bluuebunny/crossref_metadata_2025 huggingface dataset:
A Phase 1 Dose Escalation Trial of Third Generation Chimeric Antigen Receptor (CAR) T-Cell Therapy for Relapsed and Refractory B-Cell Non Hodgkin Lymphoma
Authors:   , George Philip
Published: December 2021

Anti-CD19 Chimeric Antigen Receptor (CAR) T-cell therapy is shifting the treatment paradigm internationally for selected patients with relapsed and refractory B-cell Non- Hodgkin Lymphoma. Despite high response rates with durable responses achieved in a significant proportion of patients, over 50% of patients will have progressed at one year following treatment with the currently licensed anti-CD19 CAR T-cell therapies. This modality of therapy is also associated with acute and potentially life-threatening toxicities, requiring strict risk mitigation strategies.  In this thesis, the design, preparation and implementation of a new third generation anti-CD19 CAR T-cell Phase 1 trial entitled ENABLE, for patients with relapsed and refractory B-cell Non-Hodgkin Lymphoma, is described in detail. Following a literature review of CAR T-cell therapy in patients with B-cell Non-Hodgkin Lymphoma, the rationale for the ENABLE trial design is discussed, along with regulatory and clinical requirements for setting up CAR T-cell therapy in New Zealand. The importance of international collaboration to inform aspects of study design, CAR T-cell product manufacturing and developing CAR T-cell toxicity management protocols, has been demonstrated.  The early clinical experience on the ENABLE trial is presented along with provisional safety, pharmacokinetic and efficacy data from the first participant treated. This is the first time that CAR T-cell therapy has been administered in New Zealand, demonstrating CAR T-cell expansion in vivo; but also highlighting the complexities of the CAR T-cell product manufacturing process and the importance of evaluating feasibility of CAR T-cell manufacturing, as a key secondary endpoint of the study. Further clinical experience on the ENABLE trial is crucial to develop the potential for CAR T-Cell therapy to be a safe, feasible and effective option for selected New Zealand patients in the future.
Investigation of the Rotokawa Geothermal System and Feasibility of Supercritical Fluid Production within the TVZ through Supercritical TOUGH2 Numerical Modeling.
Authors:   , Carson Benjamin
Published: December 2021

A single fault process model was created to test the sensitivity of each TOUGH2 rock parameter on the convection flow rate and fluid enthalpy within a simulated fault. With a fixed temperature base the single fault process model found a negative correlation with the fault permeability and convection fluid enthalpy and a positive liner increases in mass flow with fault area.  Next a large scale Supercritical TOUGH2 model was built to simulate the entire Rotokawa geothermal system incorporating findings of the fault process model. The single porosity model 20 x 10 x 6km with 20 layers and 57,600 grid blocks. Unlike previous models of the Rotokawa reservoir and larger scale TVZ numerical models a fixed temperature base with a no flow boundary was used to represent the brittle ductile transition. The model permeability below the currently explored reservoir was bounded by 3-D magnetologic data. Lower resistivity zones were given higher bulk permeability in the model.  The model resulted in a comparable temperature and pressure match to the Rotokawa natural state conditions. Convection of supercritical fluid reached depths shallower than -4500mRL but only occurred in zones with a bulk vertical permeability less than 2 mD. Further modelling work with a supercritical wellbore coupled reservoir model will be need to evaluate the potential deliverability of a super critical well from the Rotokawa geothermal system.
Unconventional Superconductivity in Samarium Nitride
Authors:   , Doonan William
Published: December 2021

We have studied the nature of unconventional superconductivity in the rare-earth nitride (REN) samarium nitride (SmN) for the purposes of providing a deeper understanding of the mechanisms that lead to such a phenomenon in an already extremely interesting material. An approximate low energy model has been introduced for SmN based on previous bandstructure calculation and recent experimental results. This consists of the non-dispersive 4f band associated with the samarium ion crossing through the dispersive 5d band associated with the nitrogen ion. Due to large spin polarisation in the bandstructure we need only consider the majority-spin 5d and 4f bands which lead to an essentially spinless two band system. Starting from this two band system, we apply the k dot p method to it in order to create an effective model for the system. This effective model for the material acts as the platform from which we study the possible triplet superconducting pairing. Basing our pairing on the electron-phonon interaction we have postulated the existence of triplet pairing in the 5d band, from which we have successfully characterised the pair potential in this system through the self-consistency equation. The pair potential Delta_d could be solved analytically in a special case where the Fermi level was equal to the 4f band. In this case we find that above a threshold effective coupling strength the superconducting state is established and analytically known. In contrast to this result for the more general case where the Fermi level is different to the 4f band we numerically recover a solution that was exponential in the effective coupling strength which is similar to the pairing as we expect from the single band case. Analytic solutions in this case were not able to be found, however, we know that from our numerical investigations there will exist a solution for any effective coupling strength, contrasting with the special case where the pairing amplitude can disappear below a certain threshold. In conjunction to these results we also examined the situation where the 5d and 4f bands have hybridised together in order to search for unique pairing that may be resistant to disorder. By keeping the triplet pairing only in the 5d band, this translates to hybrid pairing between electrons in the two hybridised bands. Results from the hybridised bands system show a new singlet-like pairing Delta_S which is even in k and singlet in the hybridised band indices. Preliminary numerical results suggest that this pairing indeed exists and occurs only near the avoided crossing of the hybridised bands. The existence of such a pairing, originating from triplet pairing, has exciting implications for the robustness of the superconductivity in the presence of disorder and/or impurities.
Remote Control: Organisational Control and Monitoring in Distributed Teams
Authors:   , Downes Rebecca
Published: December 2021

Qualitative data from interviews and diaries show that for managers in distributed teams, monitoring their team’s attitudes is vital. Monitoring attitudes is theorised to be a necessary part of enacting informal controls, essential for knowledge work where formal behaviour and output controls are likely to be insufficient. This suggests an extension to Ouchi’s (1977) influential Behaviour-Output framework to incorporate monitoring attitudes. Impression management and lack of physical proximity is shown to be a potential disruptor of attitude-related monitoring for managers. Pastoral control is then introduced to explain how managers utilise relational techniques to solicit information necessary for monitoring attitudes, and the role of context in enacting organisational control is explicated.
Revising the Language of the New Zealand Youth Rights Caution to Support Understanding Among Young People
Authors:   , Talbot Lydia
Published: December 2021

Many young people in New Zealand will engage in antisocial behaviour during their teenage years. Consequently, many young people will interact with the police. When young people speak to police, they are read the Child/Young Persons Rights Caution (the Youth Caution) which informs them of the rights they are entitled to (legal rights), such as choosing to stay silent and speaking with a lawyer. However, many young people have an incomplete understanding of their rights as the Youth Caution does not support complete understanding. An explanation for this incomplete understanding is the language within the Youth Caution is too complex for young people. The current study sought to address this issue by creating and piloting a revised youth caution which aimed to be simpler and easier for young people to understand. Three research questions were addressed in this study: 1) What was young people’s level of understanding of their legal rights? 2) Would the revised youth caution improve the level of legal rights understanding? 3) Would understanding of legal rights increase with age? To answer these questions, young people (aged 10-18 years) were recruited from schools and the community (n = 101). Their legal rights understanding levels were then assessed, based on hearing either the standard or the revised youth caution. The results in relation to the research questions showed participants’ legal rights understanding was incomplete, the revised youth caution did not improve understanding across any aspects of legal rights understanding and understanding increased with age. These results suggest simplifying the language within the Youth Caution is not sufficient to support young people’s understanding, and legislation could offer further support, such as requiring a lawyer to be present as the default option when young people are speaking to the police.
Do structured manipulatives aid understanding of additive reasoning, and addition and subtraction fluency in a sample of Year 7 and 8 students?
Authors:   , Green Daniel
Published: December 2021

Mathematical achievement may impact on outcomes in later life; thus, identifying and improving key mathematical skills is a focus of a large body of educational research. Both additive reasoning, and knowledge of addition and subtraction facts, appear to predict later mathematical achievement. The current study explores the impact of a short intervention with a small group of year 7 and 8 students working at lower than expected academic levels. The current study is based on Cognitive Load Theory and research suggesting that counting strategies overload working memory. A mixed-methods approach was used to identify whether structured manipulatives improved the additive reasoning and, addition and subtraction fluency in a sample of ten participants. Participants attended after-school intervention sessions of 45 minutes for seven weeks. The intervention focused on teaching additive reasoning and fluency using structured manipulatives. Inferential statistical analysis showed a statistically significant mean improvement in participants’ ability to answer simple addition and subtraction questions. Tests constructed to operationalise additive reasoning also showed statistically significant mean improvement. Participants answered diagnostic questions operationalising various aspects of additive reasoning. Individual differences in understanding of additive reasoning were observed, and the inverse relationship between addition and subtraction proved to be a challenging concept. Semi-structured interviews provided themes of valuing the intervention and the manipulatives used. Due to the size and design of this study, it is not possible to extrapolate findings to other learners. However, the study may provide directions for future research. Structured manipulatives may have a role to play in enabling learners to begin to learn additive relationships and further securing recall of addition and subtraction facts. Students at years 7 and 8 may still need considerable exposure to additive concepts; moreover, returning to manipulatives may develop this knowledge. Finally, the findings from the diagnostic questions help show the complexity of additive reasoning. Classroom practitioners may need to further develop their knowledge of additive reasoning, its importance, and the individual differences and misconceptions that learners hold in order to provide considered learning experiences.
Cheers! Selling Health and Happiness: Advertising Alcohol in New Zealand, c.1900-1945
Authors:   , Duncan Marie
Published: December 2021

Abstract At the turn of the 20th century New Zealand’s newspapers were filled with advertising material offering information on a wide variety of products. Among these advertisements were those for alcohol, a commodity which the advertisements claimed to have multiple benefits, including those of a restorative and curative nature. This thesis will examine how two product groups, alcoholic beverages claiming medicinal value, and patent medicines containing alcohol, were advertised in selected New Zealand newspapers and magazines during the years 1900-1945.  The advertising of these two groups was, in many ways, similar. Both used evocative text and images, with the images changing from drawn illustrations to photographs, and both targeted groups, linking these to specific drinks. For example, tonic wine advertising was aimed at women suffering from psychological distress, while beer and spirit advertisements targeted men and sporting codes, and patent medicine advertisements were designed to attract mothers and those suffering from respiratory illnesses. While both alcohol and patent medicines were subject to legislation this was not always effective. The Quackery Act 1908, which should have impacted on both alcohol and patent medicine advertising had no effect on either group. Patent medicine advertisers however, responded to the Physical Welfare Recreation Act 1937, and the Social Welfare Act 1938 with images of active, healthy children. The Medical Advertisements Act 1942 impacted immediately on alcohol advertising. but was not as successful with patent medicines.  Both groups had significant changes affecting their advertising. For example, patent medicine advertising was dramatically altered by the discovery of vitamins. This, to a large extent, moved the impetus of many of these advertisements from illness to health. Two factors influenced alcohol advertising: the first being Prohibition Referenda which saw the emergence of advertising focused on placing alcohol in the household medicine chest. This highlighted the use of alcohol as a commodity commonly used in the home for medical and other emergencies and these advertisements informed readers of what could be lost if prohibition were passed. The second, and most significant change came about with the Medical Advertisements Act 1942 when any mention of cure or relief became unlawful.
Cutting Edge Fabrication: Investigating Timber Sheet Materials with Robotic Fabrication
Authors:   , Cheng Celine
Published: December 2021

Timber sheet materials have been used in the same manner for decades despite having a vital role in the construction industry. This often results in indistinguishable surfaces with no identity. The research developed in this thesis is the creation of a workflow to create a self-supporting structure from sheet materials using robotic fabrication and computational tools. Timber sheet materials is the key focus for this research, as timber is a material that can be altered in a variety of ways. Japanese timber connections were a strong influence for this research, due to its prolonged life span and sustainable advantages. In the past, timber fabrication techniques have been limited due to design limitations. Current technology, specifically parametric software combined with the robotic arm was explored to find how it can create timber connections to connect sheet materials at different angles. This method was utilised to repurpose the concept of sheet materials towards a complex structure, which adopted the idea of mass customisation over mass production.   Prototypes of timber connections were created to develop an outcome that will structurally support itself. The outcome of each prototype was evaluated and compared with one another to establish which connection would be most suited to bring forward to the self-supporting structure. Computational simulations were used to explore individual structures which created panels that were automatically flattened in the software. This allowed the digital file to be transferred to the robotic arm to be milled. Using the robotic arm was an advantage, as it can rotate around six-axis giving multiple degrees of design freedom which broadened the range of construction techniques that can be used with sheet materials. There is a high chance of human error with manual labour, therefore precision is a positive attribute of the robotic arm. The precision helped minimise waste compared to manual labour. This thesis presented an opportunity for the design/construction industry to adopt a new workflow to bring leading-edge technology to focus on sustainable materials and to steer away from the repetitions evident in buildings today.
Use of item response theory in marketing research
Authors:   Hyo Jin Eom1, John Hulland2, Jordan M. Wheeler2, Seock-Ho Kim2
Published: December 2021

There are three purposes of this paper. The first is to present a brief introduction to item response theory in conjunction with marketing research. The second is to present a review of the current uses of item response theory in representative marketing research journals. The third is to present an example that illustrate and contrasts classical test theory and item response theory approaches to item and scale analysis. Several item response theory relevant papers were recently published in various marketing research journals. Because models under item response theory, from simple to complex, were used without any systematic introduction in marketing research, this paper briefly presents the main concepts in item response theory. A content analysis was done for the second purpose with 30 item response theory relevant articles in marketing research journals. Articles were sorted based on the taxonomy of item response theory models. Many articles reviewed relied on some type of unidimensional dichotomous item response theory models. Articles published recently within the past 10 years used more complicated item response theory models, both mathematically and statistically, than other previously published articles in marketing research journals. Lastly, data from a scale with three Likert-type items of four response categories were analysed using a traditional approach based on item statistics and coefficient alpha as well as using an item response theory approach by employing the graded response model. Main concepts of item response theory were explicated with figures.
Editorial
Authors: Yánez Balarezo Samuel
Published: December 2021

EDITORIAL

El presente dossier pretende analizar el modelo de comunicación en el que los interlocutores no están presentes físicamente, en el mismo lugar y/o momento, lo que hace que el proceso de comunicación cambie sustancialmente. No podemos dejar de lado las ventajas que estas nuevas formas de comunicarnos nos ofrecen, sin embargo debemos salvaguardar la humanidad de este acto.

Los avances tecnológicos en el área de las comunicaciones han acelerado el desarrollo de nuevos medios y la migración de los tradicionales a internet. Estos dan origen a los cibermedios que constituyen una situación comunicativa diferente a la de los sistemas tradicionales al incorporar la interactividad.

La expansión de las redes sociales y la tecnología móvil en la que los usuarios alcanzan todo el protagonismo tanto de productores como de consumidores, hace que se generan diálogos e intercambios dentro de la sociedad civil al margen de las grandes empresas mediáticas.

Estos cibermedios generan nuevos perfiles profesionales que han prendido la alerta en el campo de la legislación y la tributación, pero también han ampliado las brechas sociales en especial en los países menos desarrollados.

La Facultad de Derecho y Ciencias Sociales de la Universidad UTE tiene el agrado de presentar la Edición n.º 17 de Tsafiqui, Revista Científica en Ciencias Sociales. En este número el “Nuevas formas de comunicación.”

En esta edición Tsafiqui Revista Científica en Ciencias Sociales cuenta con la participación de la empresa Tikinauta junto con su director José Rivera, Phd. Y de Albertina Navas, PhD. quiénes aportaron desde su experiencia en el desarrollo de la temática de la presente edición.

El primer artículo analiza el uso de la red social TikTok por parte del candidato conservador Guillermo Lasso en su campaña presidencial. El siguiente manuscrito estudia a Puruwa TV y su contenido intercultural emitido durante el año 2020 en medio de la crisis sanitaria, social y económica de Ecuador, a través de la transversalidad que caracteriza a la interculturalidad en la cultura, salud, política, educación y ambiente. El tercer trabajo explora las experiencias más representativas realizadas en los últimos años por la agencia de comunicación española Omnicom PR Group. El siguiente envío revisa los efectos en las relaciones entre docentes y estudiantes a partir de sus prácticas comunicativas en los procesos de enseñanza-aprendizaje.

Como apertura a la sección Mosaico, se explora la trascendencia y liderazgo de la mujer en la política ecuatoriana, luego se analiza el Acoso escolar y estrategias de prevención en educación básica y nivel medio buscando las alternativas de solución. El último artículo aborda el desarrollo del pensamiento crítico a través de la lectura.
Analysis of the Effect of the European Debt Crisis on the Saudi Arabian Economy
Authors: Benlagha Noureddine , Charfeddine Lanouar
Published: December 2021

This paper investigates the economic impact of the 2009 European debt crisis on Saudi Arabia’s real economy from 2004 Q2 to 2014 Q2 using a structural vector autoregressive model (SVAR). The results of the impulse response functions obtained from the aggregated data show that the shock to European imports from Saudi Arabia had a significant impact on the real effective exchange rate, inflation rate, and economic growth that lasted for three periods. Moreover, the variance decomposition analysis shows that Europe’s imports from Saudi Arabia explain approximately 20% of the variance of the Saudi real effective exchange rate and real economic growth, 10% of the interest rate variability, and only 5% of the inflation rate variance. The results of the individual country analysis show that the impact of shocks to imports from all European countries had an instantaneous impact, except for France and Spain, where the impact on the economic growth was significant in the second and sixth periods respectively. The results suggest that Saudi Arabian policymakers should continue the process of export diversification in order to reduce its dependence on this region.
JUSTICE AND ISLAMIC WORK ETHICS A FRAMEWORK FOR LEADERS OF PUBLIC AND PRIVATE ORGANIZATIONS
Authors: Attahiru Mustapha Sidi
Published: December 2021

Immorality in the public/private service has been a great concern to various governments and researchers throughout the world because of its complexity. Despite all the existing laws, rules and regulations pertaining to the public service, the policy makers have failed to arrest the situation that is multiplying day by day. This may not be unconnected with the neglect of religious ethics that control the heart of an individual as it affects the public service. Islam provides comprehensive ethical guidelines for the running of public service which can be achieved through Islamic justice and fairness. To have faithful leaders, it is of great importance for the policy makers to ensure the manifestation of religious ethics and justice in the public service through the public awareness. Using proposed methodology this paper presents a conceptual review of the leader’s work ethics based on Islamic perspectives as well as its application in modern business toward sustaining the performance of the public and private organizations. This research is significant as there is a lack of Islamic code of ethics that guides the public and private organizations effectively. There is need for empirical test in the future as this research is conceptual in nature.
Şekil göstergeleri ve topluluk öğrenmesi sınıflandırma algoritmaları ile bina detaylarının şekil karmaşıklık analizi
Authors: DUMAN Hüseyin Safa , BAŞARANER Melih
Published: December 2021

Şekil analizi, bilgisayar görüsü, coğrafi bilgi bilimi, kartografya, uzaktan algılama, kent morfolojisi, arazi yönetimi ve ekoloji gibi çeşitli alanlarda mekansal olguları/nesneleri karakterize etmek ve mekansal örüntüleri ortaya çıkartmak için kullanılır. Bu bağlamda, şekil göstergeleri, genel olarak mekansal detayların geometrilerinin ve/veya onlardan türetilen yardımcı geometrilerin metrik özellikleri yardımıyla karmaşıklık ve benzerlik gibi şekilsel karakteristikleri niceliksel olarak ifade ederler. Bununla birlikte, şekil göstergeleri mekansal detayların farklı şekilsel özelliklerini ölçmektedir. Bu nedenle, bir detayı şekilsel olarak karakterize ederken tek bir şekil göstergesinin kullanımı her zaman yeterli olmaz. Ayrıca, bu amaçla uygun sınıflandırma yöntemlerinin kullanılması da önemlidir. Bu çalışmada, dairesellik, dışbükeylik ve dikdörtgensellik şekil göstergeleri ile rastgele orman ve gradyan artırma topluluk öğrenme sınıflandırma algoritmaları birlikte kullanılarak 300 adet bina detayı şekilsel karmaşıklık düzeylerine göre basit, orta ve karmaşık olarak sınıflandırılmıştır. Görsel algıya dayalı olarak etiketlenen veri setiyle karşılaştırıldığında rastgele orman algoritması %93.33 genel doğruluk ( = 0.900) üretirken, gradyan artırma algoritması ise %92.33 genel doğruluk (󠆻 = 0.885) üretmiştir. Bu bulgular, bina detaylarının şekilsel karmaşıklık düzeylerinin, çeşitli şekil göstergeleri ve yaygın kullanılan topluluk öğrenmesi sınıflandırma algoritmaları aracılığıyla oldukça yüksek bir doğrulukla sınıflandırılabileceğini göstermiştir.
Critical Holism as Public Health Theory: Towards A Unifying Framework for Research, Policy and Planning
Authors: Priya Ritu
Published: December 2021

The wide range of subject matter Public Health (PH) incorporates makes it a synthesizing science that draws upon very many disciplines of the natural, applied and social sciences. The sub-fields of research and application PH, epidemiology, health systems research, policy studies, health education and further sub-fields within each of these, draw from the theories of relevant base disciplines and thereby tend to think in silos rather than make the interlinkages between them. This paper argues for Critical Holism (CH) as an overarching theoretical framework that can provide PH and its sub-fields a unifying structure within which they can locate themselves in relation to each other. Thereby CH would remind PH researchers about attending to interlinkages between elements of a health problem and across problems, their multi-level and multi-dimensional complexity. Policy, planning and implementation require such unifying thought processes in order to ensure coherence between the various elements of PH action for a common objective such as policy formulation for improving the health of populations, health system strengthening, designing of programmes, pandemic response strategies and so on. PH research that generates knowledge to inform these politico-administrative processes, has also to provide them with the comprehensive lens with which to perceive the complexity of health problems, assess the resources at hand and design interventions. The paper presents an outline of what PH research adopting the Critical Holism theoretical frame would look like, as an invitation to further developments of the theoretical frame and its application.
The Deepening of Disciplinary Content: Public Health in Post-COVID India
Authors: Priya Ritu , N K Bamezai Rameshwar
Published: December 2021

We are amid the COVID-19 pandemic, the biggest public health event in a century that has caused illness in almost 180 million persons and loss of over 4 million lives worldwide, and disrupted the social and economic life of all societies. More such crises are predicted to occur in the coming decades, and there are massive pre-existing unaddressed public health needs in all countries. It is to be anticipated that in the post-COVID world there will be greater attention to the often neglected discipline of public health.
Estimación de la rentabilidad agrícola de las empresas rurales de la mixteca Oaxaqueña
Authors: Barrios Puente Gerónimo , Rosales Hortiales Arisbeth , Sangerman-Jarquín Dora María , Pérez Soto Francisco , González López Mariano , Reyes Muro Luis
Published: December 2021

En la región Mixteca en Oaxaca predomina la pobreza rural y la actividad económica común es la agricultura; sin embargo, el sector agrícola es precario y no ha reducido la pobreza. Existen pequeñas parcelas, productos tradicionales de poco valor agregado, técnicas antiguas en tecnología y no hay inversión en capital. En este sentido es necesario conocer los beneficios económicos que generan las unidades productivas (UP), visualizándolas como empresas rurales. El objetivo de la investigación fue hacer una aproximación a la estimación de la rentabilidad de la producción agrícola de las empresas rurales de la región Mixteca de Oaxaca para el año 2007 y conocer cuáles fueron los principales factores que influyeron en dicha rentabilidad, para ello se estimaron los ingresos y costos de las empresas rurales por municipio cuya diferencia arrojó el valor de rentabilidad, y mediante mínimos cuadrados ordinarios se determinaron los factores que influyen en ella. Los resultados indicaron que la rentabilidad por empresas rurales estuvo en el rango de $-19 000 a $13 000, por municipios de $-4 millones a $4 millones y por superficie de $-9 000 a $6 500 por hectárea. La producción, semillas mejoradas y tamaño de UP influyeron positivamente en el valor de rentabilidad, mientras que el autoconsumo, carecer de infraestructura, la propiedad comunal e ingresos derivados de apoyos gubernamentales la disminuyen. Finalmente, es necesario fomentar la asociación de productores que permita incrementar la producción y aumentar las prácticas de comercialización para generar mayores beneficios derivados de la agricultura.
Study on the Expression and Mechanism of Tumour-Derived IgG in Prostate Cancer
Authors: Xia Hongmei , Luo XiaoJin , Zhang Feng , Yin Weihua
Published: December 2021

ABSTRACT

The lack of effective treatment for CRPC is the leading cause of death in prostate cancer patients. However, CRPC exhibits high immunoglobulin (Ig) expression. Ig, one of the most important immune molecules, is a unique product of B lymphocytes and plays an important role in immune defence. The expression of IgG in malignant tumour tissues is positively correlated with the degree of tumour malignancy, and IgG promotes the proliferation and metastasis of tumour cells. A retrospective analysis of immunohistochemical pathological tissue sections collected from 50 patients with prostate cancer (PC) and 40 patients with prostatic hyperplasia from Yichun City People’s Hospital between May 2010 and May 2014 was conducted. The experimental group had an average age of 70.8 ± 2.7 years (58˜86 years old) and included 12 patients with low Ig expression and 38 with high Ig expression. The survival time of the former group was significantly longer than that of the latter group. In vitro, the expression of IgG protein and mRNA in PC3 cells was detected by Western blotting and RT-PCR. IgG expression was knocked down via small interfering RNA (siRNA), and the migration and invasion abilities of PC3 cells were assessed using a Transwell assay. Positive expression of tumour-derived IgG in prostate cancer can indicate poor prognosis of patients with prostate cancer, and high IgG expression promotes the invasion and metastasis of prostate cancer. Thus, IgG may become a therapeutic target in prostate cancer.
Naïve Bayes for Detecting Student’s Learning Style Using Felder-Silverman Index
Authors: Hidayat Nurul , Afuan Lasmedi
Published: December 2021

This paper focuses on detecting student learning styles using the Felder-Silverman Index Learning Style (FSLM). Providing Adaptivity based on learning styles can support students and make the learning process easier for them. However, the student learning styles need to be identified and understood to provide the appropriate adaptability. In this case, we use a questionnaire instrument to detect student’s learning styles. This paper analyses of students from Professional Education Teacher (PPG) at the Ministry of Research, Technology, and Higher Education (Kemenristek DIKTI).   The results show that 1998 students who filled out the questionnaire obtained the following conclusions for each zone with a balanced learning style about 29.9% for dimension processing, 34.78% for input dimension, and 36.98% for understanding dimension. However, most students have a moderate sensing learning style with 31.13% for each zone for the dimension of perception. This research contributes to some areas, such as providing FSLSM learning style with a large dataset and capturing students' learning styles based on four dimensions.
Pengembangan Media Teka-Teki Silang (TTS) untuk Pembelajaran Tematik Kelas VI SD
Authors: Darinah Darinah , Sukirno Sukirno
Published: December 2021

Penelitian ini bertujuan untuk mengembangkan media pembelajaran TTS pada pembelajaran tematik di kelas VI SD. Penelitian ini merupakan Research and Development (R&D). Penelitian ini dilakukan di Gugus Untung Suropati, Sampel dalam penelitian ini dipilih secara cluster random sampling dari keseluruhan populasi adalah 11 kelas yang dijadikan kelas eksperimen dan kelas kontrol. Hasil penelitian menunjukkan bahwa: (1) Tahap penyusunan dan pengembangan media TTS ditempuh melalui 3 tahapan, yaitu menganalisis kebutuhan guru, menganalisis kebutuhan siswa, dan mengembangkan media TTS sebagai media pembelajaran tematik di kelas VI SD, (2) Validitas media TTS dinyatakan valid melalui penilaian dari hasil validasi ahli I dan II, saran dan masukan yang baik untuk dikembang-kannya produk media, serta respon pengguna media TTS. Dari hasil analisis validator diperoleh rata-rata presentase berturut-turut sebesar 78% dan 74,34%, dalam kategori sangat baik dan layak digunakan dalam kegiatan pembelajaran tematik kelas VI SD, dan (3) Tingkat keefektifan media TTS pada pembelajaran tematik dapat diketahui dari hasil uji coba produk yang menunjukkan  bahwa hasil belajar pada kelas eksperimen yang menggunakan media TTS pada materi tema 9 pembelajaran tematik lebih baik daripada kelas kontrol yang menggunakan pembelajaran konvensional (buku teks). Media TTS juga mendapat respon baik oleh peserta didik.
Penyusunan Daftar Kosakata Baca Bahasa Indonesia untuk Siswa Sekolah Menengah Pertama (SMP)
Authors: Astuti Anis Mardiani , Aziez Furqanul
Published: December 2021

Penelitian ini dirancang untuk menyusun daftar kosakata baca bahasa Indonesia untuk siswa SMP bagi pembelajaran berpendekatan integratif. Penyusunan daftar kosakata baca bahasa Indonesia ini diharapkan dapat membekali siswa dengan kosakata yang memadai sehingga siswa SMP di Indonesia akan dapat membaca buku teks bahasa Indonesia secara mandiri. Untuk pembuatan bahan ajar penelitian ini akan (1) mengembangkan tiga korpora, yaitu korpus buku teks bahasa Indonesia SMP kelas satu, dua, dan tiga, sebagai basis analisis, (2) mengidentifikasi distribusi lexical set untuk tiap korpus, (3) mengindentifikasi total kata minimum untuk dapat membaca buku teks secara mandiri, dan (4) mambuat bahan ajar berupa daftar kosakata baca untuk siswa SMP. Untuk kepentingan pembuatan bahan ajar ini, lematisasi dilakukan dengan manual, sedangkan analisis karakteristik kosakata dengan WebVocabProfiler (Cobb, 2009), yang memberikan data- data tentang level kosakata korpus, kandungan kosakata akademik interdisipliner yang ada dalam Coxhead’s (2000) AWL, indikator level kosakata tiap kata, dan kosakata yang ada di luar 2000 dan 5000 keluarga kata pertama (asumsi level kosakata masing-masing kelas).
Optical and A.C. Electrical Properties for Polypyrrole and Polypyrrole/Graphene (ppy/gn) Nanocomposites
Authors: Ahmed Fatima Mikdad , Hassan Salma M.
Published: December 2021

In this work, chemical oxidation was used to polymerize conjugated polymer "Polypyrrole" at room temperature Graphene nanoparticles were added by in situ-polymerization to get (PPY-GN) nano. Optical and Electrical properties were studied for the nanocomposites. optical properties of the nanocomposites were studied by UV-Vis spectroscopy at wavelength range (200 -800 nm). The result showed optical absorption spectra were normally determined and the result showed that the maximum absorbance wave length at 280nm and 590nm. The optical energy gap has been evaluated by direct transition and the value has decreased from (2.1 eV for pure PPy) to (1.3 eV for 5 %wt. of GN). The optical constants such as the band tail width ΔE was evaluated, the value of ΔE for pure PPy was (0.0949eV) while for 5 wt. % of GN it was (0.5156 eV), It has been observed that the Urbach tail for pure PPy was smaller than that for PPy/GN nanocomposites and it increase as GN concentration increases. The A.C electrical conductivity at range of frequency (103Hz-106Hz) was increased by increasing the frequency and GN concentration about four order of magnitude. The s value was about (0.653-0.962) which means that the mechanism of conductivity is correlated hopping mechanism (C. H. P.). The dielectric constant and dielectric lose were determined and found to decrease with increasing frequency.
Impact of Aluminum Oxide Content on the Structural and Optical Properties of ZnO: AlO Thin Films
Authors: Abass Hawraa Hadi , Hasan Bushra A
Published: December 2021

AlO-doped ZnO nanocrystalline thin films from with nano crystallite size in the range (19-15 nm) were fabricated by pulsed laser deposition technique. The reduction of crystallite size by increasing of doping ratio shift the bandgap to IR region the optical band gap decreases in a consistent manner, from 3.21to 2.1 eV by increasing AlO doping ratio from 0 to 7wt% but then returns to grow up to 3.21 eV by a further increase the doping ratio. The bandgap increment obtained for 9% AlO dopant concentration can be clarified in terms of the Burstein–Moss effect whereas the aluminum donor atom increased the carrier's concentration which in turn shifts the Fermi level and widened the bandgap (blue-shift). The engineering of the bandgap by low concentration of AlO dopant makes ZnO: AlO thin films favorable for the fabrication of optoelectronic devices. The optical constants were calculated and was found to be greatly affected by the increasing the doping ratio.
Variation of pH and Composite Dosage on the Photocatalytic Activity for ZnO/epoxy Nanocomposites
Authors: Alrubaie Haneen Abass , Muzahem Ban M.
Published: December 2021

In this research, Zinc oxide (ZnO)/epoxy nanocomposite was synthesized by simple casting method with 2wt. % ZnO concentration. The aim of this work was to study the effect of pH and composite dosage on the photocatalytic activity of ZnO/ epoxy nanocomposite. Scanning electron microscopy (SEM) technique images proof the homogeneous distribution of ZnO nanoparticles in epoxy. A synthesized nanocomposite samples were characterized by Fourier Transform Infrared spectrometer (FTIR) measurements. Two spectra for epoxy and 2wt.% ZnO/epoxy nanocomposites were similar and there are no new bonds formed from the incorporation of ZnO nanoparticles. Using HCl and NaOH were added to Methylene blue (MB) dye (5ppm) to gat pH values 3 and 8. The degradation of the dye was 90.816% were pH =8 after 180 min. under sun-light. The degradation was 6.131% were pH=3 after 240 min. under sun-light irradiation. It is found that the base solution help in accelerating the photocatalytic process, pH with high value provides greater concentration of hydroxyl ions which interact with h+ to form hydroxyl radicals OH- that give an enhancement degradation rate of dyes. The dose of ZnO was increased from 3g to 6g with Methylene blue MB (5ppm) the degradation was 94.3755% after 240 min. under sun-light irradiation. This means that increasing the dose of ZnO, the photocatalytic activity will be increased.
Study FTIR and AC Conductivity of Nanocomposite Electrolytes
Authors: Swady Elaaf Ali , Jawad Mohammed K.
Published: December 2021

In the present work polymer electrolytes were formulated using the solvent casting technique. Under special conditions, the electrolyte content was of fixed ratio of polyvinylpyrolidone (PVP): polyacrylonitrile (PAN) (25:75), ethylene carbonate (EC) and propylene carbonate (PC) (1:1) with 10% of potassium iodide (KI) and iodine I2 = 10% by weight of KI. The conductivity was increased with the addition of ZnO nanoparticles. It is also increased with the temperature increase within the range (293 to 343 K). The conductivity reaches maximum value of about (0.0296 S.cm-1) with (0.25 g) ZnO. The results of FTIR for blend electrolytes indicated a significant degree of interaction between the polymer blend (PVP and PAN) and the KI salt. From the electrolyte observations of the nanocomposites, the broad peak became narrower after adding the ZnO nanoparticle to the KI salt. The dielectric reaction decreased with the increase of the frequency at room temperature. The high dielectric permittivity of the polymer at lower frequencies can be attributed to the dipoles having sufficient time to get aligned with the electric field, resulting in higher polarization.
Structural and Infrared Spectroscopy of Polyvinylpyrrolidone/Multi-walled Carbon Nanotubes Nanocomposite
Authors: Omran Shahad M. , Abdullah Estabraq T. , Al-Zuhairi Omar A.
Published: December 2021

In this work, polyvinylpyrrolidone (PVP)/ Multi-walled carbon nanotubes (MWCNTs) nanocomposites were prepared with two concentrations of MWCNTs by casting method. Morphological, structural characteristics and electrical properties were investigated. The state of MWCNTs dispersion in a PVP matrix was indicated by Field Effect-Scanning Electron Microscopy (FESEM) which showed a uniform dispersion of MWCNTs within the PVP matrix. X-ray Diffraction (XRD) indicate strong bonding of carbonyl groups of PVP composite chains with MWCNTs. Fourier transfer infrared (FTIR) studies shows characteristics of various stretching and bending vibration bands, as well as shifts in some band locations and intensity changes in others. Hall effect was studied to test the type of charge carriers which was shown to be P-type. The electrical conductivity was shown increased for the pure PVP and pure MWCNT from (2.047×10-5) (Ω.cm)-1 and (3.683×101) (Ω.cm)-1 to (2.51×102 and 2.36×102) (Ω.cm)-1for both concentrations of nanocomposites, which indicate the conductivity was enhancement by using the carbon nanotubes.
Hemodynamic Effects of Cardiovascular Medications in a Normovolemic and Hemorrhaged Yorkshire-cross Swine Model
Authors: Cole Jacob H , Hughey Scott B , Geiger Phillip G , Rapp-Santos Kamala J , Booth Gregory J
Published: December 2021

The Yorkshire-cross swine model is a valuable translational model commonly used to study cardiovascular physiology and response to insult. Although the effects of vasoactive medications have been well described in healthy swine, the effects of these medications during hemorrhagic shock are less studied. In this study, we sought to expand the utility of the swine model by characterizing the hemodynamic changes that occurred after the administration of commonly available vasoactive medications during euvolemic and hypovolemic states. To this end, we anesthetized and established femoral arterial, central venous, and pulmonary arterial access in 15 juvenile Yorkshire-cross pigs. The pigs then received a series of rapidly metabolized but highly vasoactive medications in a standard dosing sequence. After completion of this sequence, each pig underwent a 30-mL/kg hemorrhage over 10 min, and the standard dosing sequence was repeated. We then used standard sta- tistical techniques to compare the effects of these vasoactive medications on a variety of hemodynamic parameters between the euvolemic and hemorrhagic states. All subjects completed the study protocol. The responses in the hemorrhagic state were often attenuated or even opposite of those in the euvolemic state. For example, phenylephrine decreased the mean arterial blood pressure during the euvolemic state but increased it in the hemorrhagic state. These results clarify previously poorly defined responses to commonly used vasoactive agents during the hemorrhagic state in swine. Our findings also demonstrate the need to consider the complex and dynamic physiologic state of hemorrhage when anticipating the effects of vasoactive drugs and planning study protocols.
Toward Global Harmonization of Training and Certification of Specialists in Laboratory Animal Veterinary Medicine
Authors: Hedenqvist Patricia , Baumans Vera , Hanai Koji , Yano Kazuo , Yeom Su Cheong , Song Eun Ju , Devan Shakthi RK , Klein Hilton J , Bailey Michele M
Published: December 2021

Laboratory animal medicine (LAM) is a corner stone of animal-based research and has been a veterinary specialty for over 60 y. Today 5 Colleges of LAM (American, European, Japanese, Korean, and Indian) that certify specialists (Diplomates) in LAM are members of the International Association
of Colleges of LAM (IACLAM). Goals of IACLAM are to support the development of new Colleges of LAM, to harmonize expectations for the knowledge and skills of newly certified LAM Diplomate, and to harmonize the standards (best practices) for training and examination of candidates among the
member Colleges. IACLAM recently conducted an in-depth review and comparison of oversight, training, credentialing, and examination standards in the 5 Colleges as part of an initiative to create a framework for harmonization and consistency for these activities across the 5 Colleges. The process
has led to an agreement on recommendations for knowledge and skill requirements for a newly certified Diplomate, as described by each College in a detailed role delineation document (RDD). The RDD is based on task analyses of the work responsibilities of laboratory animal veterinary Diplomates.
This agreement is an important step toward the goal of global harmonization of LAM Diplomate training. Further efforts are planned for areas such as training, research, publication, and examination. This paper describes the role and content of the RDD and lists the differences and similarities
among the RDDs of 5 Colleges of LAM.
ALABRÚS IGLESIAS, Rosa María, Juliana Morell. De niña prodigio a maestra de las emociones. Sant Cugat (Barcelona), Arpegio, 2020, 109 pp. ISBN: 978-84-15798-42-2
Authors: Pérez Semper María Ángeles
Published: December 2021

Rosa Mª Alabrús comenzó su trayectoria investigadora con una tesis doctoral dedicada al estudio del pensamiento político y la opinión en la Cataluña Moderna (1652-1759) presentada en la Universidad Autónoma de Barcelona, tesis posteriormente recogida en un libro titulado Felip V i l’opinió dels catalans (2001). Después de trabajar varios años en las relaciones entre Cataluña y la Monarquía Española, a partir del año 2009 el principal objeto de investigación de la Dra. Alabrús pasó a ser el discurso de las Órdenes religiosas en la Corona de Aragón, con un tema dominante como eje: la tensión entre tradición y mo- dernidad en la dialéctica entre dominicos y jesuitas (Sílex, 2011), la memoria y el legado cultural de los dominicos (Arpegio, 2012) y la vida y la sociabilidad de los conventos dominicos (Arpegio, 2013)…