bluuebunny/crossref_metadata_2025 huggingface dataset:
UV–Vis Absorption Properties of New Aromatic Imines and Their Compositions with Poly({4,8-bis[(2-Ethylhexyl)oxy]Benzo[1,2-b:4,5-b′]Dithiophene-2,6-diyl}{3-Fluoro-2-[(2-Ethylhexyl)Carbonyl]Thieno[3,4-b]Thiophenediyl})
Authors: Gonciarz Agnieszka , Pich Robert , Bogdanowicz Krzysztof Artur , Jewloszewicz Beata , Przybył Wojciech , Dysz Karolina , Dylong Agnieszka , Kwak Anna , Kaim Andrzej , Iwan Agnieszka , Rusin Jaroslaw , Januszko Adam
Published: December 2019

In this paper, four new aromatic imines containing at least one thiazole-based heterocycle were analyzed in detail by UV–Vis spectroscopy, taking into consideration their chemical structures and interactions with PTB7, a known polymeric electron donor widely used in bulk heterojunction organic solar cells. It is demonstrated that the absorption spectra of the investigated active compositions can be modified not only by changing the chemical structure of imine, but also via formulations with PTB7. For all investigated imines and PTB7:imine compositions, calibration curves were obtained in order to find the optimum concentration in the composition with PTB7 for expansion and optimization of absorption spectra. All imines and PTB7:imine compositions were investigated in 1,2-dichlorobenzene by UV–Vis spectroscopy in various concentrations, monitoring the changes in the π–π* and n–π* transitions. With increasing imine concentrations, we did not observe changes in absorption maxima, while with increasing imine concentrations, a hypochromic effect was observed. Finally, we could conclude that all investigated compositions exhibited wide absorptions of up to 800 nm and isosbestic points in the range of 440–540 nm, confirming changes in the macromolecular organization of the tested compounds. The theoretical calculations of their vibration spectra (FTIR) and LUMO–HOMO levels by Density Functional Theory (DFT) methods are also provided. Finally, IR thermal images were measured for organic devices based on imines and the imine:PTB7 composite.
Development of Marine Antifouling Epoxy Coating Enhanced with Clay Nanotubes
Authors: Fu Ye , Wang Wencai , Zhang Liqun , Vinokurov Vladimir , Stavitskaya Anna , Lvov Yuri
Published: December 2019

An antifouling epoxy resin doped with natural clay nanotubes that are loaded with biocide or silver allowed extended protection against the proliferation of marine microorganisms. Compared to the 2–3 months of protection with antifoulant dichlorooctylisothiazolone (DCOIT) directly admixed into epoxy resin, the DCOIT release time of the halloysite formulations was extended to 12 months by incorporating biocide-loaded nanoclay in the polymer matrix. The protective properties of the epoxy-halloysite nanocomposites showed much less adhesion and proliferation of marine bacteria Vibrio natriegens on the resin surface after a two-month exposure to seawater than the coating formulations directly doped with non-encapsulated DCOIT. The coating formulation protection efficiency was further confirmed by twelve-month shallow field tests in the South China Sea. Replacing 2 wt.% biocide in the traditional formula with DCOIT-loaded natural environmentally friendly halloysite clay drastically improved the antifouling properties of the epoxy coating, promising scalable applications in protective marine coating. The antifouling property of epoxy resin was enhanced with silver particles synthesized on halloysite nanotubes. A natural mixture of MnO particles and halloysite could also be used as a nonbiocide additive to marine coating. The short-term White Sea water test of epoxy coating with 5% of Ag-halloysite composite of MnO-halloysite natural mixture showed no visible fouling.
Analysis of Cement Deterioration in Outdoor High-Voltage Insulator
Authors: Kim Taeyong , Sanyal Simpy , Koo Ja-Bin , Son Ju-Am , Choi In-Hyuk , Yi Junsin
Published: December 2019

Suspension type porcelain insulators used in overhead transmission lines comprise metal, ceramic, and cement. The deterioration of cement can lead to mechanical separation. For the degradation analysis, varied sizes of pores ranging from a few µm (capillary pores) to tens to hundreds of mm (detectable by naked eyes) were considered. Cracks that were hard to view with naked eyes were identified by staining with a fuchsine solution. The hydrogen ion concentration and pH value indicate the extent to which the cement is deteriorated. The longer the cement is used, the lower its pH value. High mechanical strength is considered an important advantage of porcelain insulators, and it may decline, if the cement is used for a longer period of time. Water ingress may also occur, resulting in expansion, due to the rehydration of the cement. The process and mechanism of expansion of cement, due to infiltration of water were described. As a method of analysis, a universal indicator was employed to evaluate the pH changes in cement. It was observed that the pH value was 12–13 for new products. However, for products that were used for 52 years, the pH value was under 7, which indicated an acidic tendency, due to deterioration.
Digital Supply Chain through Dynamic Inventory and Smart Contracts
Authors: De Giovanni Pietro
Published: December 2019

This paper develops a digital supply chain game, modeling marketing and operation interactions between members. The main novelty of the paper concerns a comparison between static and dynamic solutions of the supply chain game achieved when moving from traditional to digital platforms. Therefore, this study proposes centralized and decentralized versions of the game, comparing their solutions under static and dynamic settings. Moreover, it investigates the decentralized supply chain by evaluating two smart contracts: Revenue sharing and wholesale price contracts. In both cases, the firms use an artificial intelligence system to determine the optimal contract parameters. Numerical and qualitative analyses are used for comparing configurations (centralized, decentralized), settings (static, dynamic), and contract schemes (revenue sharing contract, wholesale price contract). The findings identify the conditions under which smart revenue sharing mechanisms are worth applying.
Application of Differential Evolution Algorithm Based on Mixed Penalty Function Screening Criterion in Imbalanced Data Integration Classification
Authors: Gao Yuelin , Wang Kaiguang , Gao Chenyang , Shen Yulong , Li Teng
Published: December 2019

There are some processing problems of imbalanced data such as imbalanced data sets being difficult to integrate efficiently. This paper proposes and constructs a mixed penalty function data integration screening criterion, and proposes Differential Evolution Integration Algorithm Based on Mixed Penalty Function Screening Criteria (DE-MPFSC algorithm). In addition, the theoretical validity and the convergence of the DE-MPFSC algorithm are analyzed and proven by establishing the Markov sequence and Markov evolution process model of the DE-MPFSC algorithm. In this paper, the entanglement degree and enanglement degree error are introduced to analyze the DE-MPFSC algorithm. Finally, the effectiveness and stability of the DE-MPFSC algorithm are verified by UCI machine learning datasets. The test results show that the DE-MPFSC algorithm can effectively improve the effectiveness and application of imbalanced data classification and integration, improve the internal classification of imbalanced data and improve the efficiency of data integration.
Decision Making Approach under Pythagorean Dombi Fuzzy Graphs for Selection of Leading Textile Industry
Authors: Akram Muhammad , Mohsan Dar Jawaria , Shahzadi Sundas
Published: December 2019

Graphs play a pivotal role in structuring real-world scenarios such as network security and expert systems. Numerous extensions of graph theoretical conceptions have been established for modeling uncertainty in graphical network situations. The Pythagorean Dombi fuzzy graph (PDFG), a generalization of the fuzzy Dombi graph (FDG), is very useful in representing vague relations between several objects, whereas the operational parameter has a flexible nature in decision-making problems. The main objective of this research study is to expand the area of discussion on PDFGs by establishing fruitful results and notions related to operations such as the direct product, Cartesian product, semi-strong product, strong product, and composition on PDFGs. Certain concepts, including the degree of vertices and total degree, are discussed as its modifications. Meanwhile, these outcomes are considered on PDFGs maintaining the strongness property. At the end, an algorithm for Pythagorean Dombi fuzzy multi-criteria decision-making is given, and a numerical example based on the selection of a leading textile industry is put forward to clarify the suitability of the proposed approach.
Isolation, Optimization of Fermentation Conditions, and Characterization of an Exopolysaccharide from Pseudoalteromonas agarivorans Hao 2018
Authors: Hao Lujiang , Liu Wenlin , Liu Kai , Shan Kai , Wang Chunlei , Xi Chenxiang , Liu Jianbang , Fan Qiuping , Zhang Xiaofei , Lu Xiaoping , Xu Yanrui , Cao RuiWen , Ma Yaohong , Zheng Lan , Cui Bo
Published: December 2019

In recent years, the wide application of exopolysaccharides (EPSs) in food, cosmetics, medicine, and other fields has drawn tremendous attention. In this study, an EPS produced by Pseudoalteromonas agarivorans Hao 2018 was isolated and purified, and its fermentation conditions were optimized. Its structure and biological functions were also studied. The purity and molecular weight of EPS were determined by high performance liquid chromatography (HPLC), and the EPS exhibited a number average of 2.26 × 105 and a weight average of 2.84 × 105. EPS has good adsorption for Cu2+ and Pb2+. The adsorption rates can reach up to 69.79% and 82.46%, respectively. The hygroscopic property of EPS was higher than that of chitosan, but slightly lower than that of sodium hyaluronate. However, the water-retaining activity of EPS was similar to that of chitosan and sodium hyaluronate. EPS has strong ability to scavenge free radicals, including OH radical and O2− radical. Further, its activity on O2− radicals has similarities with that of vitamin C. EPS has broad application prospects in many fields, such as cosmetics, environmental protection.
Stable Tetrodotoxin Production by Bacillus sp. Strain 1839
Authors: Melnikova Daria I. , Vlasenko Anna E. , Magarlamov Timur Yu.
Published: December 2019

For the first time, tetrodotoxin (TTX) was detected in a bacterial strain after five years of cultivation in laboratory conditions since its isolation from the animal host. A reliable method suitable for bacterial samples, high-performance liquid chromatography with tandem mass spectrometry, was used for toxin detection in spore and vegetative cultures of Bacillus sp. 1839. TTX was detected in a spore culture of the strain.
Comparison of Charge Storage Properties of Prussian Blue Analogues Containing Cobalt and Copper
Authors: Rensmo Amanda , Hampton Jennifer R.
Published: December 2019

Prussian blue analogues are of great interest as alternative battery materials because of their long life cycle and potential use of earth-abundant elements. In this work, thin film mixed-metal hexacyanoferrates (HCFs) based on NiCo and NiCu alloys were fabricated in an all electrochemical process. The structure and composition of the samples were characterized, along with the charge storage capacity and kinetics of the charge transfer reaction. For both NiCo-HCF and NiCu-HCF samples, the total charge capacity increased with the substitution of Ni with more Co or Cu, and the increase was larger for Cu samples than for Co samples. On the other hand, the charge storage kinetics had only a modest change with substituted metal, and these effects were independent of the amount of that substitution. Thus, the mixed-metal HCFs have promise for increasing overall storage capacity without negatively influencing the rate capability when used in battery applications.
Metamorphic Age Comparison and Its Implications between the Zuoquan and Zanhuang Complexes in the Central North China Craton, Based on LA-ICP-MS Zircon U–Pb Dating
Authors: Xiao Ling-Ling , Chen Min-Hua
Published: December 2019

The Trans-North China Orogen (TNCO) is well-known as an early Precambrian orogenic belt in the North China Craton (NCC). Three meaningful groups of metamorphic ages have been reported in the metamorphic complexes throughout the TNCO, including c. 1.85 Ga, c. 1.95 Ga, and c. 2.5 Ga. The spatial distributions and relationships of these ages provide notable insight into the formation timing and tectonic evolution of the NCC basement. The Zuoquan and Zanhuang complexes are exposed in the south–central TNCO and are adjacent to the Eastern Block. In order to place new constraints on the timing of two phases of metamorphism that occurred in the complexes, combined U–Pb and rare earth element analyses were performed on zircons from different types of metamorphic rocks. Uranium–Pb zircon dating in this study shows that two groups of metamorphic ages of 1.88–1.85 Ga and 2.48–2.46 Ga were commonly recorded by metamorphic rocks in the Zanhuang and Zuoquan complexes, respectively. Our previous geochronological studies showed that metamorphic ages of c. 2.51 Ga and c. 1.90 Ga were locally recorded in the Zanhuang and Zuoquan complexes, respectively. These data indicate that metamorphic rocks in the two complexes underwent at least two phases of metamorphism, i.e., 2.51–2.46 Ga (Phase I) and 1.90–1.85 Ga (Phase II). In combination with previous studies regarding reaction microstructures, metamorphic pressure–temperature paths, and geochronology, the Phase II metamorphic ages are interpreted to be linked to the collision between the Western and Eastern Blocks along the TNCO between 1.97 Ga and 1.80 Ga, whereas the Phase I metamorphic ages, as a result of an earlier and extensive tectono-thermal event that occurred in the Eastern and Western Blocks of the NCC, were related to underplating of mantle-derived magma. It is inferred that the rocks with c. 2.51–2.46 Ga metamorphic ages in the two complexes formed in the Eastern Block and underwent regional metamorphism during that period, and then were tectonically involved in the TNCO and experienced c. 1.90–1.85 Ga metamorphism. Metamorphic peaks occurred at different crustal levels in the orogen, resulting in distinct metamorphic ages and peak conditions preserved by metamorphic rocks in the two complexes.
Mustard Gold in the Oleninskoe Gold Deposit, Kolmozero–Voronya Greenstone Belt, Kola Peninsula, Russia
Authors: Kalinin Arkadii A. , Savchenko Yevgeny E. , Selivanova Ekaterina A.
Published: December 2019

The Oleninskoe intrusion-related gold–silver deposit is the first deposit in the Precambrian of the Fennoscandian Shield, where mustard gold has been identified. The mustard gold replaces küstelite with impurities of Sb and, probably, gold-bearing dyscrasite and aurostibite. The mosaic structure of the mustard gold grains is due to different orientations and sizes of pores in the matrix of noble metals. Zonation in the mustard gold grains is connected with mobilization and partial removal of silver from küstelite, corresponding enrichment of the residual matter in gold, and also with the change in the composition of the substance filling the pores. Micropores in the mustard gold are filled with iron, antimony or thallium oxides, silver chlorides, bromides, and sulfides. The formation of mustard gold with chlorides and bromides shows that halogens played an important role in the remobilization of noble metals at the stage of hypergene transformation of the Oleninskoe deposit.
Development of Asialoglycoprotein Receptor-Targeted Nanoparticles for Selective Delivery of Gemcitabine to Hepatocellular Carcinoma
Authors: Nair Anroop B. , Shah Jigar , Al-Dhubiab Bandar E. , Patel Snehal S. , Morsy Mohamed A. , Patel Vimal , Chavda Vishal , Jacob Shery , Sreeharsha Nagaraja , Shinu Pottathil , Attimarad Mahesh , Venugopala Katharigatta N.
Published: December 2019

Selective targeting of anticancer drugs to the tumor site is beneficial in the pharmacotherapy of hepatocellular carcinoma (HCC). This study evaluated the prospective of galactosylated chitosan nanoparticles as a liver-specific carrier to improve the therapeutic efficacy of gemcitabine in HCC by targeting asialoglycoprotein receptors expressed on hepatocytes. Nanoparticles were formulated (G1–G5) by an ionic gelation method and evaluated for various physicochemical characteristics. Targeting efficacy of formulation G4 was evaluated in rats. Physicochemical characteristics exhibited by nanoparticles were optimal for administering and targeting gemcitabine effectively to the liver. The biphasic release behavior observed with G4 can provide higher drug concentration and extend the pharmacotherapy in the liver target site. Rapid plasma clearance of gemcitabine (70% in 30 min) from G4 was noticed in rats with HCC as compared to pure drug (p < 0.05). Higher uptake of gemcitabine predominantly by HCC (64% of administered dose; p < 0.0001) demonstrated excellent liver targeting by G4, while mitigating systemic toxicity. Morphological, biochemical, and histopathological examination as well as blood levels of the tumor marker, alpha-fetoprotein, in rats confirmed the curative effect of G4. In conclusion, this study demonstrated site-specific delivery and enhanced in vivo anti-HCC efficacy of gemcitabine by G4, which could function as promising carrier in hepatoma.
Effects of Puerarin on the Ovariectomy-Induced Depressive-Like Behavior in ICR Mice and Its Possible Mechanism of Action
Authors: Tantipongpiradet Ariyawan , Monthakantirat Orawan , Vipatpakpaiboon Onchuma , Khampukdee Charinya , Umehara Kaoru , Noguchi Hiroshi , Fujiwara Hironori , Matsumoto Kinzo , Sekeroglu Nazim , Kijjoa Anake , Chulikhit Yaowared
Published: December 2019

Daily treatment of ovariectomized (OVX) ICR mice with puerarin, a glycosyl isoflavone isolated from the root bark of Pueraria candollei var. mirifica, and 17β-estradiol attenuated ovariectomy-induced depression-like behavior, as indicated by a decrease in immobility times in the tail suspension test (TST) and the forced swimming test (FST), an increase in the uterine weight and volume, a decrease in serum corticosterone levels, and dose-dependently normalized the downregulated transcription of the brain-derived neurotrophic factor (BDNF) and estrogen receptor (Erβ and Erα) mRNAs. Like 17β-estradiol, puerarin also inhibited ovariectomy-induced suppression of neurogenesis in the dentate gyrus of the hippocampus (increased the number of doublecortin (DCX)-immunosuppressive cells). These results suggest that puerarin exerts antidepressant-like effects in OVX animals, possibly by attenuating the OVX-induced hyperactivation of the HPA axis and/or normalizing the downregulated transcription of BDNF and ER mRNA in the brain.
Nitriding an Oxygen-Doped Nanocarbonaceous Sorbent Synthesized via Solution Plasma Process for Improving CO2 Adsorption Capacity
Authors: Pornaroontham Phuwadej , Panomsuwan Gasidit , Chae Sangwoo , Saito Nagahiro , Thouchprasitchai Nutthavich , Phongboonchoo Yuththaphan , Pongstabodee Sangobtip
Published: December 2019

The synthesis of carbon nanoparticles (Cn) and oxygen-doped nanocarbon (OCn) was successfully done through a one-step synthesis by the solution plasma process (SPP). The Cn and OCn were nitrogen-doped by nitridation under an ammonia atmosphere at 800 °C for 2 h to yield NCn and NOCn, respectively, for carbon dioxide (CO2) adsorption. The NOCn exhibited the highest specific surface area (~570 m2 g−1) and highest CO2 adsorption capacity (1.63 mmol g−1 at 25 °C) among the synthesized samples. The primary nitrogen species on the surface of NOCn were pyridinic-N and pyrrolic-N. The synergistic effect of microporosity and nitrogen functionality on the NOCn surface played an essential role in CO2 adsorption enhancement. From the thermodynamic viewpoint, the CO2 adsorption on NOCn was physisorption, exothermic, and spontaneous. The NOCn showed a more negative enthalpy of adsorption, indicating its stronger interaction for CO2 on the surface, and hence, the higher adsorption capacity. The CO2 adsorption on NOCn over the whole pressure range at 25–55 °C best fitted the Toth model, suggesting monolayer adsorption on the heterogeneous surface. In addition, NOCn expressed a higher selective CO2 adsorption than Cn and so was a good candidate for multicycle adsorption.
A Dietary Pattern with High Sugar Content Is Associated with Cardiometabolic Risk Factors in the Pomak Population
Authors: Farmaki Aliki-Eleni , Rayner Nigel W , Kafyra Maria , Matchan Angela , Ntaoutidou Kyriaki , Feritoglou Pournar , Athanasiadis Antonis , Gilly Arthur , Mamakou Vasiliki , Zengini Eleni , Karaleftheri Maria , Zeggini Eleftheria , Dedoussis George
Published: December 2019

The present study describes the geographically isolated Pomak population and its particular dietary patterns in relationship to cardiovascular risk factors. We collected a population-based cohort in a cross-sectional study, with detailed anthropometric, biochemical, clinical, and lifestyle parameter information. Dietary patterns were derived through principal component analysis based on a validated food-frequency questionnaire, administered to 1702 adult inhabitants of the Pomak villages on the Rhodope mountain range in Greece. A total of 69.9% of the participants were female with a population mean age of 44.9 years; 67% of the population were overweight or obese with a significantly different prevalence for obesity between men and women (17.5% vs. 37.5%, respectively, p < 0.001). Smoking was more prevalent in men (45.8% vs. 2.2%, p < 0.001), as 97.3% of women had never smoked. Four dietary patterns emerged as characteristic of the population, and were termed “high in sugars”, “quick choices”, “balanced”, and “homemade”. Higher adherence to the “high in sugars” dietary pattern was associated with increased glucose levels (p < 0.001) and increased risk of hypertension (OR (95% CI) 2.61 (1.55, 4.39), p < 0.001) and nominally associated with high blood glucose levels (OR (95% CI) 1.85 (1.11, 3.08), p = 0.018), compared to lower adherence. Overall, we characterize the dietary patterns of the Pomak population and describe associations with cardiovascular risk factors.
Sarcopoterium spinosum Inhibited the Development of Non-Alcoholic Steatosis and Steatohepatitis in Mice
Authors: Wollman Ayala , Daniel Tehila , Rosenzweig Tovit
Published: December 2019

Non-alcoholic fatty liver disease (NAFLD) is a comorbidity of obesity, which gradually develops from hepatic steatosis into steatohepatitis (NASH) and eventually even into fibrosis or hepatic carcinoma. To date, there has been no specific and effective treatment for NAFLD. Sarcopoterium spinosum extract (SSE) was found to improve insulin sensitivity. Recognizing the intimate link between insulin resistance and NAFLD, the aim of this study was to investigate the effectivity of SSE in the prevention and management of NAFLD at various severities. SSE was given to high-fat diet (HFD)-fed mice (steatosis model) or to mice given a Western diet (WD) in the short or long term (NASH prevention or treatment, respectively). SSE reduced body weight accumulation, improved glucose tolerance and insulin sensitivity and prevented the development of hepatic steatosis. SSE also blocked the progression of liver disease toward NASH in a dose-dependent manner. The expression of genes involved in lipid metabolism, inflammation, and antioxidant machinery was regulated by SSE in both models of steatosis and NASH development. However, SSE failed to reverse the hepatic damage in the advanced model of NASH. In summary, SSE might be considered as a botanical supplement for the prevention and treatment of hepatic steatosis, and for slowing the deterioration toward NASH.
Nutrient Estimation from 24-Hour Food Recalls Using Machine Learning and Database Mapping: A Case Study with Lactose
Authors: Chin Elizabeth L. , Simmons Gabriel , Bouzid Yasmine Y. , Kan Annie , Burnett Dustin J. , Tagkopoulos Ilias , Lemay Danielle G.
Published: December 2019

The Automated Self-Administered 24-Hour Dietary Assessment Tool (ASA24) is a free dietary recall system that outputs fewer nutrients than the Nutrition Data System for Research (NDSR). NDSR uses the Nutrition Coordinating Center (NCC) Food and Nutrient Database, both of which require a license. Manual lookup of ASA24 foods into NDSR is time-consuming but currently the only way to acquire NCC-exclusive nutrients. Using lactose as an example, we evaluated machine learning and database matching methods to estimate this NCC-exclusive nutrient from ASA24 reports. ASA24-reported foods were manually looked up into NDSR to obtain lactose estimates and split into training (n = 378) and test (n = 189) datasets. Nine machine learning models were developed to predict lactose from the nutrients common between ASA24 and the NCC database. Database matching algorithms were developed to match NCC foods to an ASA24 food using only nutrients (“Nutrient-Only”) or the nutrient and food descriptions (“Nutrient + Text”). For both methods, the lactose values were compared to the manual curation. Among machine learning models, the XGB-Regressor model performed best on held-out test data (R2 = 0.33). For the database matching method, Nutrient + Text matching yielded the best lactose estimates (R2 = 0.76), a vast improvement over the status quo of no estimate. These results suggest that computational methods can successfully estimate an NCC-exclusive nutrient for foods reported in ASA24.
The Relationship between Self-Reported Exposure to Sugar-Sweetened Beverage Promotions and Intake: Cross-Sectional Analysis of the 2017 International Food Policy Study
Authors: Forde Hannah , White Martin , Levy Louis , Greaves Felix , Hammond David , Vanderlee Lana , Sharp Stephen , Adams Jean
Published: December 2019

Sugar-sweetened beverage (SSB) consumption is independently associated with several non-communicable diseases, so policymakers are increasingly implementing measures, such as marketing regulation, to reduce intake. To help understand how such measures work, this study examined the association between SSB consumption and self-reported exposure to SSB promotions, both overall and by type of promotion, and whether these relationships vary between the UK, USA, Canada, Mexico, and Australia. Cross-sectional analysis of the online 2017 International Food Policy Study was performed (n = 15,515). Participants were grouped into 5265 (34%) non-, 5117 (33%) low-, and 5133 (33%) high-SSB consumers. Multinomial logistic regression models examined whether SSB consumption varied by exposure to total SSB promotion and by type: traditional, digital, recreational environment, and functional environment. Multiplicative interactions were included to investigate international variations. An additional unit of total self-reported SSB promotion exposure increased the likelihood of participants being low SSB consumers (relative risk ratio (RRR) = 1.08, 95% confidence interval (CI) = 1.06–1.10) and high SSB consumers (RRR = 1.13, 95% CI = 1.11–1.16). Only exposure to traditional and digital promotion increased the likelihood of participants being SSB consumers, though this may be explained by degree of exposure, which was not measured in this study. Some evidence illustrated international variation in these relationships.
Moderate Alcohol Intake in Non-Alcoholic Fatty Liver Disease: To Drink or Not to Drink?
Authors: Petroni Maria L. , Brodosi Lucia , Marchignoli Francesca , Musio Alessandra , Marchesini Giulio
Published: December 2019

Nonalcoholic fatty liver disease (NAFLD) is defined by hepatic steatosis in the presence of alcohol intake within safe limits, defined by guidelines of scientific associations (usually 20 g or 2 units/day in women, 30 g or 3 units in men). The diagnosis is usually followed by medical counseling of total abstinence, in order to prevent disease progression. This policy has been challenged by epidemiological studies, suggesting that the risk of liver disease and disease progression is lower in modest drinkers than in total abstainers. We revised the literature on the effects of modest alcohol intake on disease burden. Epidemiological data may suffer from several potential biases (recall bias for retrospective analyses, difficulties in the calculation of g/day), limiting their validity. Prospective data suggest that NAFLD patients with regular alcohol intake, although within the safe thresholds, are at higher risk of liver disease progression, including hepatocellular carcinoma; a detrimental effect of modest alcohol drinking is similarly observed in liver disease of viral etiology. Alcohol intake is also a risk factor for extrahepatic cancers, particularly breast, oral, and pharyngeal cancers, with gender difference and no floor effect, which outweigh the possible beneficial effects on cardiovascular system, also derived from retrospective studies. Finally, the negative effects of the calorie content of alcohol on dietary restriction and weight loss, the pivotal intervention to reduce NAFLD burden, should be considered. In summary, the policy of counseling NAFLD patients for alcohol abstinence should be maintained.
Dietary and Lifestyle Patterns in the Spanish Pediatric Population (One to <10 Years Old): Design, Protocol, and Methodology of the EsNuPI Study
Authors: Madrigal Casandra , Soto-Méndez María José , Hernández-Ruiz Ángela , Ruiz Emma , Valero Teresa , Ávila José Manuel , Lara-Villoslada Federico , Leis Rosaura , Martínez de Victoria Emilio , Moreno Jose Manuel , Ortega Rosa M , Ruiz-López María Dolores , Varela-Moreiras Gregorio , Gil Ángel
Published: December 2019

The interest in a healthy diet and lifestyle during the early stages of life increased, pointing out its role in the development of noncommunicable chronic diseases throughout adult life. Dietary habits and dietary patterns begin to be established in early childhood and persist during adulthood. Therefore, the EsNuPI (“Nutritional Study in Spanish Pediatric Population”) study aims to depict the dietary patterns, physical activity, and sedentary behaviors in Spanish children aged from one to <10 years old. This prospective, cross-sectional, observational study recruited a total of 1514 children from Spanish cities with >50,000 inhabitants, stratified by Nielsen areas. Participants were involved in one face-to-face survey, followed by a telephone survey after at least one week. Information about dietary intake and habits was obtained using a quantitative food frequency questionnaire and two 24-h dietary recalls. Physical activity and sedentary behaviors were registered using a specific questionnaire based on a seven-day record. Data were processed and stratified by categorical variables to be statistically analyzed in order to meet the study objectives. This study is the first of its kind in a Spanish reference population of this age range and the first to evaluate whether the consumption of adapted milk formulas and dairy products is associated with healthier dietary patterns and better diet quality and lifestyles in this group.
Associations Among Taste Perception, Food Neophobia and Preferences in Type 1 Diabetes Children and Adolescents: A Cross-Sectional Study
Authors: Mameli Chiara , Cattaneo Camilla , Lonoce Luisa , Bedogni Giorgio , Redaelli Francesca Chiara , Macedoni Maddalena , Zuccotti Gianvincenzo , Pagliarini Ella
Published: December 2019

Type 1 diabetes (T1D) is one of the most common systemic diseases in childhood which predisposes the patient to serious short-term and long-term complications, affecting all body systems. Taste and olfactory impairments were first described a long time ago in adult patients affected by diabetes (both type 1 and type 2 diabetes). However, studies evaluating taste perception, behavioral attitudes (e.g., food neophobia), and preferences toward foods in children and adolescents affected by T1D are globally lacking. Therefore, the purpose of this study was to assess taste sensitivity, food neophobia, and preferences among children and adolescents affected by T1D and healthy controls in a cross-sectional study. T1D patients presented a significantly lower ability in general to correctly identify taste qualities, especially bitter and sour tastes. Moreover, they were characterized by fewer fungiform papillae compared to controls, as well as a lower responsiveness to the bitter compound 6-n-propylthiouracil (PROP). There were no significant differences in food neophobia scores between the two groups, but differences were observed in the mean hedonic ratings for some product categories investigated. Diabetic patients showed a greater liking for certain type of foods generally characterized by sourness and bitterness, an observation probably linked to their impaired ability to perceive taste stimuli, e.g., sourness and bitterness. These results may help to enhance the understanding of these relationships in populations with elevated diet-related health risks.
Dihydropyranocoumarins Exerted Anti-Obesity Activity In Vivo and its Activity Was Enhanced by Nanoparticulation with Polylactic-Co-Glycolic Acid
Authors: Hossin Abu , Inafuku Masashi , Oku Hirosuke
Published: December 2019

Dihydropyranocoumarins (DPCs) were isolated from Peucedanum japonicum Thunb as anti-obesity compounds in 3T3-L1 adipocytes assay; however, it is uncertain whether DPC exerts anti-obesity activity in vivo. Therefore, this study evaluated the oral intake of pure DPCs in mice fed a high-fat diet, and also attempted to enhance its activity by nanoparticulation. Increases in body weight gain and fat accumulation in white adipose tissues were significantly suppressed by the dietary intake of DPCs (1.943 mg/mouse/day). DPCs intake also significantly decreased the mean size of adipocytes and upregulated mRNA levels of thermogenesis-related genes. Nanoparticulation of DPCs with polylactic-co-glycolic acid (PLGA) dramatically increased its activity almost 100-fold over that of a non-nanoparticulated form. Thus, our findings clearly demonstrated the anti-obesity activity of DPCs in vivo and suggested that PLGA nanoparticle encapsulation was useful to enhance the anti-obesity activity of DPCs with the aim to develop natural and safe anti-obesity agents.
The Striking Flower-in-Flower Phenotype of Arabidopsis thaliana Nossen (No-0) is Caused by a Novel LEAFY Allele
Authors: Mohrholz Anne , Sun Hequan , Glöckner Nina , Hummel Sabine , Kolukisaoglu Üner , Schneeberger Korbinian , Harter Klaus
Published: December 2019

The transition to reproduction is a crucial step in the life cycle of any organism. In Arabidopsis thaliana the establishment of reproductive growth can be divided into two phases: Firstly, cauline leaves with axillary meristems are formed and internode elongation begins. Secondly, lateral meristems develop into flowers with defined organs. Floral shoots are usually determinate and suppress the development of lateral shoots. Here, we describe a transposon insertion mutant in the Nossen accession with defects in floral development and growth. Most strikingly is the outgrowth of stems from the axillary bracts of the primary flower carrying secondary flowers. Therefore, we named this mutant flower-in-flower (fif). However, the transposon insertion in the annotated gene is not the cause for the fif phenotype. By means of classical and genome sequencing-based mapping, the mutation responsible for the fif phenotype was found to be in the LEAFY gene. The mutation, a G-to-A exchange in the second exon of LEAFY, creates a novel lfy allele and results in a cysteine-to-tyrosine exchange in the α1-helix of LEAFY’s DNA-binding domain. This exchange abolishes target DNA-binding, whereas subcellular localization and homomerization are not affected. To explain the strong fif phenotype against these molecular findings, several hypotheses are discussed.
Traditional Uses of Leguminosae among the Karen in Thailand
Authors: Sutjaritjai Natcha , Wangpakapattanawong Prasit , Balslev Henrik , Inta Angkhana
Published: December 2019

Leguminosae (legumes) are one of the largest plant families. They are widely used for a variety of purposes by people around the world and include many important cultivated economic food crops. On local scales, legumes are commonly used by various ethnic groups. However, the data are incomplete and scattered, not least in Thailand. We found that species of legumes were important in Karen communities, so we decided to investigate in detail the traditional knowledge of legumes on a local scale among Karen people in northern Thailand. We interviewed six herbalists and eighty-four nonherbalist informants in three Karen villages in Chiang Mai province about their use of legumes, and about the local names for the species, using semistructured interviews. A total of 83 legumes species (in 45 genera) had 4443 use reports. Five of the 83 legume species had not been reported previously as used in Thailand. Most Karen use reports (43%) of legumes were for food, medicine (36%), and materials (8%), but in term of species more legumes (68 species) were used for medicine than for food (53 species). The legume genera with most used species were Crotalaria and Flemingia each with six species. The most important species are Tamarindus indica (CI = 3.38), Senegalia rugata (CI = 2.39), Glycine max (CI = 1.27) respectively.
Research Progress on the Functions of Gasotransmitters in Plant Responses to Abiotic Stresses
Authors: Yao Yandong , Yang Yan , Li Changxia , Huang Dengjing , Zhang Jing , Wang Chunlei , Li Weifang , Wang Ni , Deng Yuzheng , Liao Weibiao
Published: December 2019

Abiotic stress is one of the major threats affecting plant growth and production. The harm of abiotic stresses includes the disruption of cellular redox homeostasis, reactive oxygen species (ROS) production, and oxidative stress in the plant. Plants have different mechanisms to fight stress, and these mechanisms are responsible for maintaining the required homeostasis in plants. Recently, the study of gasotransmitters in plants has attracted much attention, especially for abiotic stress. In the present review, abiotic stressors were mostly found to induce gasotransmitter production in plants. Meanwhile, these gasotransmitters can enhance the activity of several antioxidant enzymes, alleviate the harmfulness of ROS, and enhance plant tolerance under various stress conditions. In addition, we introduced the interaction of gasotransmitters in plants under abiotic stress. With their promising applications in agriculture, gasotransmitters will be adopted in the near future.
A Selenone-Functionalized Polyhedral Oligomeric Silsesquioxane for Selective Detection and Adsorption of Hg2+ ions in Aqueous Solutions
Authors: Liu Hailong , Chen Zixu , Feng Shengyu , Wang Dengxu , Liu Hongzhi
Published: December 2019

Developing novel functional polyhedral oligomeric silsesquioxane (POSS) for various applications is highly desirable. Herein we present the first example of a novel selenone-functionalized POSS (POSS-Se) by treating an imidazolium-containing POSS with selenium powder under mild condition. The structure of POSS-Se was characterized by FT-IR, 1H NMR, 13C NMR, 29Si NMR, and elemental analysis. Acid treatment of POSS-Se results in a hydrophilic red-orange colored solid, which is highly sensitive and selective for the detection of Hg2+ ions in aqueous solutions by visually observing the color change to pale yellow, and to white. Interestingly, POSS-Se has no activity on this detection. This finding is due to the Se–Se formation by acid-treatment and subsequent coordination-induced cleavage upon the addition of Hg2+ ions. The detection behavior can be precisely monitored by a “turn-on” fluorescence phenomenon with the limit of detection (LOD) of 8.48 ppb, comparable to or higher than many reported Hg2+ sensors. Moreover, POSS-Se demonstrates a selective and efficient adsorption of Hg2+ ions with a maximum capacity of 952 mg g–1. The value is higher than most reported adsorbents for Hg2+ ions, typically thiol and/or thioether functional materials, indicating its promise as an efficient adsorbent for the selective removal of Hg2+ ions from industrial wastewater. This work may open up new horizons for the exploration of selenium-containing functional POSS.
Perspectives of Molecularly Imprinted Polymer-Based Drug Delivery Systems in Cancer Therapy
Authors: Bodoki Andreea Elena , Iacob Bogdan-Cezar , Bodoki Ede
Published: December 2019

Despite the considerable effort made in the past decades, multiple aspects of cancer management remain a challenge for the scientific community. The severe toxicity and poor bioavailability of conventional chemotherapeutics, and the multidrug resistance have turned the attention of researchers towards the quest of drug carriers engineered to offer an efficient, localized, temporized, and doze-controlled delivery of antitumor agents of proven clinical value. Molecular imprinting of chemotherapeutics is very appealing in the design of drug delivery systems since the specific and selective binding sites created within the polymeric matrix turn these complex structures into value-added carriers with tunable features, notably high loading capacity, and a good control of payload release. Our work aims to summarize the present state-of-the art of molecularly imprinted polymer-based drug delivery systems developed for anticancer therapy, with emphasis on the particularities of the chemotherapeutics’ release and with a critical assessment of the current challenges and future perspectives of these unique drug carriers.
GC-MS Screening for the Identification of Potential Migrants Present in Polymeric Coatings of Food Cans
Authors: Lestido Cardama Antía , Sendón Raquel , Bustos Juana , Santillana M. Isabel , Paseiro Losada Perfecto , Rodríguez Bernaldo de Quirós Ana
Published: December 2019

The coatings used in cans can release complex chemical mixtures into foodstuffs. Therefore, it is important to develop analytical methods for the identification of these potential migrant compounds in packaged food to guarantee the compliance with European food packaging legislation and ensure consumer safety. In the present work, the type of coating in a total of twelve cans collected in Santiago de Compostela (Spain) were evaluated using an ATR (attenuated total reflectance)-FTIR spectrometer. These samples were analysed after extraction with acetonitrile in order to identify potential migrants through a screening method by gas chromatography coupled to mass spectrometry (GC-MS). A total of forty-seven volatile and semi-volatile compounds were identified in these samples, including plasticizers, photoinitiators, antioxidants, lubricants, etc. Then, in a second step, a targeted analysis was carried out for the simultaneous determination of 13 compounds, including bisphenols (BPA, BPB, BPC, BPE, BPF, BPG) and BADGEs (BADGE, BADGE.H2O, BADGE.2H2O, BADGE.HCl, BADGE.2HCl, BADGE.H2O.HCl, cyclo-di-BADGE) by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) with atmospheric pressure chemical ionisation (APCI) source. Among all the bisphenols analysed, only the bisphenol A was detected in four samples; while cyclo-di-BADGE was the predominant compound detected in all the samples analysed.
Recent Innovation of Metal-Organic Frameworks for Carbon Dioxide Photocatalytic Reduction
Authors: Kidanemariam Alemayehu , Lee Jiwon , Park Juhyun
Published: December 2019

The accumulation of carbon dioxide (CO2) pollutants in the atmosphere begets global warming, forcing us to face tangible catastrophes worldwide. Environmental affability, affordability, and efficient CO2 metamorphotic capacity are critical factors for photocatalysts; metal-organic frameworks (MOFs) are one of the best candidates. MOFs, as hybrid organic ligand and inorganic nodal metal with tailorable morphological texture and adaptable electronic structure, are contemporary artificial photocatalysts. The semiconducting nature and porous topology of MOFs, respectively, assists with photogenerated multi-exciton injection and adsorption of substrate proximate to void cavities, thereby converting CO2. The vitality of the employment of MOFs in CO2 photolytic reaction has emerged from the fact that they are not only an inherently eco-friendly weapon for pollutant extermination, but also a potential tool for alleviating foreseeable fuel crises. The excellent synergistic interaction between the central metal and organic linker allows decisive implementation for the design, integration, and application of the catalytic bundle. In this review, we presented recent MOF headway focusing on reports of the last three years, exhaustively categorized based on central metal-type, and novel discussion, from material preparation to photocatalytic, simulated performance recordings of respective as-synthesized materials. The selective CO2 reduction capacities into syngas or formate of standalone or composite MOFs with definite photocatalytic reaction conditions was considered and compared.
Structural Characterization and Antioxidant Activity of Milled Wood Lignin from Xylose Residue and Corncob
Authors: Xu Miaomiao , Wang Chao , Lyu Gaojin , Zhong Lei , Yang Liyuan , Wang Zhiwei , Qin Chengrong , Ji Xingxiang , Yang Guihua , Chen Jiachuan , Xu Feng
Published: December 2019

Xylose residue (XR), after diluted acid treatment of corncob, consists of cellulose and lignin. However, structural changes of XR lignin have not been investigated comprehensively, and this has seriously hindered the efficient utilization of lignin. In this study, corncob milled wood lignin (CC MWL), and xylose residue milled wood lignin (XR MWL) were isolated according to the modified milled wood lignin (MWL) method. The structural features of two lignin fractions were thoroughly investigated via fourier transform infrared spectroscopy (FTIR), gel permeation chromatography (GPC), thermogravimetric analysis (TGA) and two dimensional nuclear magnetic resonance (2D NMR) spectroscopy techniques. XR MWL with higher yield and lower bound carbohydrate contents presented more phenolic OH contents than CC MWL due to partial cleavage of β-O-4. Furthermore, the molecular weights of XR MWL were increased, possibly because of condensation of the lignin during the xylose production. A study on antioxidant activity showed that XR lignin had better radical scavenging ability than that of 2,6-Di-tert-butyl-4-methyl-phenol (BHT) and CC MWL. The results suggested that the lignin in xylose residue, showing great antioxidant properties, has potential applications in food additives.
Review of Anaerobic Digestion Modeling and Optimization Using Nature-Inspired Techniques
Authors: Ramachandran Anjali , Rustum Rabee , Adeloye Adebayo J.
Published: December 2019

Although it is a well-researched topic, the complexity, time for process stabilization, and economic factors related to anaerobic digestion call for simulation of the process offline with the help of computer models. Nature-inspired techniques are a recently developed branch of artificial intelligence wherein knowledge is transferred from natural systems to engineered systems. For soft computing applications, nature-inspired techniques have several advantages, including scope for parallel computing, dynamic behavior, and self-organization. This paper presents a comprehensive review of such techniques and their application in anaerobic digestion modeling. We compiled and synthetized the literature on the applications of nature-inspired techniques applied to anaerobic digestion. These techniques provide a balance between diversity and speed of arrival at the optimal solution, which has stimulated their use in anaerobic digestion modeling.