bluuebunny/crossref_metadata_2025 huggingface dataset:
Is the digit effect a cognate effect? Digits (still) differ from pictures in non-phonologically mediated language switching
Authors: Liu Hong , Chaouch-Orozco Adel
Published: November 2022

Language control in bilinguals is often investigated with the language switching paradigm. Switch costs reflect the ease/difficulty of applying this control mechanism. The type of stimuli employed in the experiments may influence switch costs. To date, only one study has compared digit vs picture processing, reporting reduced switch costs for digits (Declerck, Koch & Philipp, 2012). This result was adjudicated to phonological overlap between the languages used. Crucially, it remains an open question whether this digit effect generalises to language combinations without phonological relation. We fill this gap by investigating language switching with two language pairs differing in relative proficiency (L1 Chinese–L2 English, L1 Chinese–L3 French), where cross-language phonological activation is not expected. Overall, a digit effect is observed in the Chinese–English pair. Contrary to Declerck et al.'s (2012) finding, digits increased switch costs. Phonological mediation cannot explain this effect; instead, we suggest its origin lies in within-language word association links.
Residential urban food environment profiles and diet outcomes among adults in Brooklyn, New York: a cross-sectional study
Authors: Figueroa Roger , Baker Katherine , Capellan Joel , Pinheiro Laura C , Burd Laura , Lim Jane , Chiong Reah , Eboh Relicious , Phillips Erica
Published: November 2022

Objective:

To assess the clustering properties of residential urban food environment indicators across neighbourhoods and to determine if clustering profiles are associated with diet outcomes among adults in Brooklyn, New York.

Design:

Cross-sectional.

Setting:

Five neighbourhoods in Brooklyn, New York.

Participants:

Survey data (n1493) were collected among adults in Brooklyn, New York between April 2019 and September 2019. Data for food environment indicators (fast-food restaurants, bodegas, supermarkets, farmer’s markets, community kitchens, Supplemental Nutrition Assistance Program application centres, food pantries) were drawn from New York databases. Latent profile analysis (LPA) was used to identify individuals’ food access-related profiles, based on food environments measured by the availability of each outlet within each participant’s 800-m buffer. Profile memberships were associated with dietary outcomes using mixed linear regression.

Results:

LPA identified four residential urban food environment profiles (with significant high clusters ranging from 17 to 57 across profiles): limited/low food access, (n587), bodega-dense (n140), food swamp (n254) and high food access (n512) profiles. Diet outcomes were not statistically different across identified profiles. Only participants in the limited/low food access profile were more likely to consume sugar-sweetened beverages (SSB) than those in the bodega-dense profile (b = 0·44,P< 0·05) in adjusted models.

Conclusions:

Individuals in limited and low food access neighbourhoods are vulnerable to consuming significant amounts of SSB compared with those in bodega-dense communities. Further research is warranted to elucidate strategies to improve fruit and vegetable consumption while reducing SSB intake within residential urban food environments.
Industry Size and Trade Protection in the Presence of Environmental Regulations: An Empirical Investigation of the Indian Manufacturing Sector
Authors: Bhattacharya Gaurav
Published: November 2022

This paper tests the hypothesis pertaining to the interdependencies between trade and environmental policies in the presence of industry/firm lobbies, which is captured through industry/firm size. For an unbalanced panel of manufacturing firms in India at the five-digit National Industrial Classification (NIC), 2008 for the period 2008–2019, I find that firm size has a positive and significant impact on trade policy. The same holds true for a subset of firms that are polluting in nature (based on the Central Pollution Control Board classification). It is found that larger firms have a greater influence on those trade policies that are set unilaterally by the government. Also, there is no empirical support in favour of trade and environment linkages in the Indian context. This could be due to the fact that these two policies come under the domain of independent ministries of the government. Moreover, environmental safety assumes less significance and tends to adversely affect the competitiveness of the manufacturing sector. Notwithstanding the fact that environmental regulations are in place, the enforcement and monitoring mechanisms are remarkably weak on account of weak environmental institutions.
Colorectal cancer treatment in people with severe mental illness: a systematic review and meta-analysis
Authors: Protani Melinda M. , Alotiby Meshary Khaled N. , Seth Rebecca , Lawrence David , Jordan Susan J. , Logan Hayley , Kendall Bradley J. , Siskind Dan , Sara Grant , Kisely Steve
Published: November 2022

Aims

People with severe mental illness (SMI) have a greater risk of dying from colorectal cancer (CRC), even though the incidence is lower or similar to that of the general population This pattern is unlikely to be solely explained by lifestyle factors, while the role of differences in cancer healthcare access or treatment is uncertain

Methods

We undertook a systematic review and meta-analysis on access to guideline-appropriate care following CRC diagnosis in people with SMI including the receipt of surgery, chemo- or radiotherapy. We searched for full-text articles indexed by PubMed, EMBASE, PsychInfo and CINAHL that compared CRC treatment in those with and without pre-existing SMI (schizophrenia, schizoaffective, bipolar and major affective disorders). Designs included cohort or population-based case–control designs.

Results

There were ten studies (sample size = 3501–591 561). People with SMI had a reduced likelihood of surgery (RR = 0.90, 95% CI 0.92–0.97;p= 0.005;k= 4). Meta-analyses were not possible for the other outcomes but in results from individual studies, people with SMI were less likely to receive radiotherapy, chemotherapy or sphincter-sparing procedures. The disparity in care was greatest for those who had been psychiatric inpatients.

Conclusions

People with SMI, including both psychotic and affective disorders, receive less CRC care than the general population. This might contribute to higher case-fatality rates for an illness where the incidence is no higher than that of the general population. The reasons for this require further investigation, as does the extent to which differences in treatment access or quality contribute to excess CRC mortality in people with SMI.
The Last Nationwide Smallpox Epidemic in the Netherlands: Infectious Disease and Social Inequalities in Amsterdam, 1870–1872
Authors: Muurling Sanne , Riswick Tim , Buzasi Katalin
Published: November 2022

The complex relationship between the history of infectious diseases and social inequalities has recently attracted renewed attention. Smallpox has so far largely escaped this revived scholarly scrutiny, despite its century-long status as one of the deadliest and widespread of all infectious diseases. Literature has demonstrated important differences between rural and urban communities, and between cities, but has so far failed to address intra-urban disparities due to varying living conditions and disease environments. This article examines the last nationwide upsurge of smallpox in the Netherlands through the lens of Amsterdam’s 50 neighborhoods in the period 1870–72. We use a mixed methods approach combining qualitative spatial analysis and OLS regression to investigate which part of the population was affected most by this epidemic in terms of age and sex, geographic distribution across the city, and underlying sociodemographic neighborhood characteristics such as relative wealth, housing density, crude death rate, and birth rate. Our analyses reveal a significant spatial patterning of smallpox mortality that can largely be explained by the existing social environment. Lacking universal vaccination, the smallpox epidemic was not socially neutral, but laid bare some of the deep-seated social and health inequalities across the city.
The Global Biogeochemical Cycle of Arsenic
Authors: Schlesinger William H. , Klein Emily M. , Vengosh Avner
Published: November 2022

Direct exploitation and use of arsenic resources has diminished in recent years, but inadvertent mobilizations of As from mineral extractions (metal ores, coal, and phosphate rock) are now as much as ten‐fold greater (1,500–5,600 × 109 g/yr) than the As released by the natural rate of rock weathering at the Earth's surface (60–544 × 109 g/yr). Although some As from mining activities enters global cycling through leaching and spills, the amount of dissolved As in rivers (23 × 109 g/yr) is similar to the theoretical mobilization of As from chemical weathering. Anthropogenic emissions to the atmosphere (17–38 × 109 g As/yr) are double the natural background sources (10–25 × 109 g As/yr), largely as a result of the smelting of Cu and other non‐ferrous ores. This results in increased atmospheric deposition near regions with high mining and industrial activities, with potential consequences to human health, natural ecosystems and agriculture. Using median values for As, the ratio of anthropogenic to natural emissions to the atmosphere (1.57) suggests a human impact on the global As cycle that rivals those for V, Hg and Pb.
Disparities in Air Pollutants Across Racial, Ethnic, and Poverty Groups at US Public Schools
Authors: Cheeseman Michael J. , Ford Bonne , Anenberg Susan C. , Cooper Matthew J. , Fischer Emily V. , Hammer Melanie S. , Magzamen Sheryl , Martin Randall V. , van Donkelaar Aaron , Volckens John , Pierce Jeffrey R.
Published: November 2022

We investigate socioeconomic disparities in air quality at public schools in the contiguous US using high resolution estimates of fine particulate matter (PM2.5) and nitrogen dioxide (NO2) concentrations. We find that schools with higher proportions of people of color (POC) and students eligible for the federal free or reduced lunch program, a proxy for poverty level, are associated with higher pollutant concentrations. For example, we find that the median annual NO2 concentration for White students, nationally, was 7.7 ppbv, compared to 9.2 ppbv for Black and African American students. Statewide and regional disparities in pollutant concentrations across racial, ethnic, and poverty groups are consistent with nationwide results, where elevated NO2 concentrations were associated with schools with higher proportions of POC and higher levels of poverty. Similar, though smaller, differences were found in PM2.5 across racial and ethnic groups in most states. Racial, ethnic, and economic segregation across the rural‐urban divide is likely an important factor in pollution disparities at US public schools. We identify distinct regional patterns of disparities, highlighting differences between California, New York, and Florida. Finally, we highlight that disparities exist not only across urban and non‐urban lines but also within urban environments.
Subseasonal Tropical Cyclone Prediction and Modulations by MJO and ENSO in CESM2
Authors: Li Hui , Richter Jadwiga H. , Lee Chia‐Ying , Kim Hyemi
Published: November 2022

Subseasonal tropical cyclone (TC) reforecasts from the Community Earth System Model version 2 (CAM6) subseasonal prediction system are examined in this study. We evaluate the modeled TC climatology and the probabilistic forecast skill of basin‐wide TC genesis at weekly temporal resolution. Prediction skill is calculated using the Brier skill score relative to a constant annual mean climatology and to a monthly varying seasonal climatology during TC season. The model captures the observed basin‐wide climatological TC seasonality and spatial distributions at weeks 1–6, but TC genesis is largely underestimated from Week 2 onward. For some basins and lead times, the predicted TC genesis is primarily controlled by the number of TC “seeds” and the mean‐state climate condition. The model has good prediction skill relative to the constant climatology across all the basins and lead times, but is only skillful in the eastern Pacific, North Indian Ocean, and Southern Hemisphere at Week 1 when compared to the seasonal climatology, indicating limited skill in predicting deviations from the seasonal cycle. We find strong modulations of the predicted TC genesis at up to 3 weeks of forecast lead time by the Madden‐Julian Oscillation. The interannual variability of predicted TC genesis and accumulated cyclone energy are skillfully predicted in the North Atlantic and the Northwestern Pacific, with a strong modulation by the El Nino‐Southern Oscillation.
Heterotrophic Bacteria Respond Differently to Increasing Temperature and Dissolved Organic Carbon Sources in Two Tropical Coastal Systems
Authors: Lønborg Christian , Baltar Federico , Calleja Maria Ll. , Morán Xosé Anxelu G.
Published: November 2022

Temperature and substrate availability are important variables controlling marine heterotrophic bacterial activity. However, particularly in tropical regions it remains to be determined how these variables jointly affect bacterial activity. In this study we show how bacterial carbon cycling in two tropical coastal ecosystems (the Great Barrier Reef [GBR, Australia] and the Red Sea [Saudi Arabia]) are influenced by changing temperature (using a 6°C gradient) and the addition of dissolved organic carbon (DOC) from different sources (addition of mangroves and seagrass leachates, plus natural seawater). Our study demonstrates that elevated temperatures in the GBR increased bacterial organic carbon processing, while in the Red Sea no clear effects were found. More of the added DOC was degraded in the Red Sea but this additional carbon did not increase the biomass production, due to low bacterial growth efficiencies in all treatments. In addition, increasing temperatures in the GBR resulted in lower bacterial growth efficiencies, while no clear impact were found in the Red Sea. In conclusion, this study suggests that site‐specific ecosystem differences (e.g., different microbial and macrophyte community composition) may override general responses to temperature and substrate in tropical coastal waters.
Pharmacological targeting of cognitive impairment in depression: recent developments and challenges in human clinical research
Authors: Colwell Michael J. , Tagomori Hosana , Chapman Sarah , Gillespie Amy L. , Cowen Philip J. , Harmer Catherine J. , Murphy Susannah E.
Published: November 2022

Impaired cognition is often overlooked in the clinical management of depression, despite its association with poor psychosocial functioning and reduced clinical engagement. There is an outstanding need for new treatments to address this unmet clinical need, highlighted by our consultations with individuals with lived experience of depression. Here we consider the evidence to support different pharmacological approaches for the treatment of impaired cognition in individuals with depression, including treatments that influence primary neurotransmission directly as well as novel targets such as neurosteroid modulation. We also consider potential methodological challenges in establishing a strong evidence base in this area, including the need to disentangle direct effects of treatment on cognition from more generalised symptomatic improvement and the identification of sensitive, reliable and objective measures of cognition.
Machine learning the Hohenberg-Kohn map for molecular excited states
Authors: Bai Yuanming , Vogt-Maranto Leslie , Tuckerman Mark E. , Glover William J.
Published: November 2022

The Hohenberg-Kohn theorem of density-functional theory establishes the existence of a bijection between the ground-state electron density and the external potential of a many-body system. This guarantees a one-to-one map from the electron density to all observables of interest including electronic excited-state energies. Time-Dependent Density-Functional Theory (TDDFT) provides one framework to resolve this map; however, the approximations inherent in practical TDDFT calculations, together with their computational expense, motivate finding a cheaper, more direct map for electronic excitations. Here, we show that determining density and energy functionals via machine learning allows the equations of TDDFT to be bypassed. The framework we introduce is used to perform the first excited-state molecular dynamics simulations with a machine-learned functional on malonaldehyde and correctly capture the kinetics of its excited-state intramolecular proton transfer, allowing insight into how mechanical constraints can be used to control the proton transfer reaction in this molecule. This development opens the door to using machine-learned functionals for highly efficient excited-state dynamics simulations.
Three-to-one analog signal modulation with a single back-bias-controlled reconfigurable transistor
Authors: Simon Maik , Mulaosmanovic Halid , Sessi Violetta , Drescher Maximilian , Bhattacharjee Niladri , Slesazeck Stefan , Wiatr Maciej , Mikolajick Thomas , Trommer Jens
Published: November 2022

Reconfigurable field effect transistors are an emerging class of electronic devices, which exploit a structure with multiple independent gates to selectively adjust the charge carrier transport. Here, we propose a new device variant, where not only p-type and n-type operation modes, but also an ambipolar mode can be selected solely by adjusting a single program voltage. It is demonstrated how the unique device reconfigurability of the new variant can be exploited for analog circuit design. The non-linearity of the ambipolar mode can be used for frequency doubling without the generation of additional harmonics. Further, phase shifter and follower circuits are enabled by the n- and p-type modes, respectively. All three functions can be combined to create a 3-to-1 reconfigurable analog signal modulation circuit on a single device enabling wireless communication schemes. Both, the concept as well as the application have been experimentally demonstrated on industrial-scale fully-depleted SOI platform. The special transport physics in those structures has been analyzed by TCAD simulations as well as temperature dependent measurements.
Evaluation of cutaneous immune response in a controlled human in vivo model of mosquito bites
Authors: Guerrero David , Vo Hoa Thi My , Lon Chanthap , Bohl Jennifer A. , Nhik Sreynik , Chea Sophana , Man Somnang , Sreng Sokunthea , Pacheco Andrea R. , Ly Sokna , Sath Rathanak , Lay Sokchea , Missé Dorothée , Huy Rekol , Leang Rithea , Kry Hok , Valenzuela Jesus G. , Oliveira Fabiano , Cantaert Tineke , Manning Jessica E.
Published: November 2022

Mosquito-borne viruses are a growing global threat. Initial viral inoculation occurs in the skin via the mosquito ‘bite’, eliciting immune responses that shape the establishment of infection and pathogenesis. Here we assess the cutaneous innate and adaptive immune responses to controlledAedes aegyptifeedings in humans living inAedes-endemic areas. In this single-arm, cross-sectional interventional study (trial registration #NCT04350905), we enroll 30 healthy adult participants aged 18 to 45 years of age from Cambodia between October 2020 and January 2021. We perform 3-mm skin biopsies at baseline as well as 30 min, 4 h, and 48 h after a controlled feeding by uninfectedAedes aegyptimosquitos. The primary endpoints are measurement of changes in early and late innate responses in bitten vs unbitten skin by gene expression profiling, immunophenotyping, and cytokine profiling. The results reveal induction of neutrophil degranulation and recruitment of skin-resident dendritic cells and M2 macrophages. As the immune reaction progresses T cell priming and regulatory pathways are upregulated along with a shift to Th2-driven responses and CD8+T cell activation. Stimulation of participants’ bitten skin cells withAedes aegyptisalivary gland extract results in reduced pro-inflammatory cytokine production. These results identify key immune genes, cell types, and pathways in the human response to mosquito bites and can be leveraged to inform and develop novel therapeutics and vector-targeted vaccine candidates to interfere with vector-mediated disease.
Host biology, ecology and the environment influence microbial biomass and diversity in 101 marine fish species
Authors: Minich Jeremiah J. , Härer Andreas , Vechinski Joseph , Frable Benjamin W. , Skelton Zachary R. , Kunselman Emily , Shane Michael A. , Perry Daniela S. , Gonzalez Antonio , McDonald Daniel , Knight Rob , Michael Todd P. , Allen Eric E.
Published: November 2022

Fish are the most diverse and widely distributed vertebrates, yet little is known about the microbial ecology of fishes nor the biological and environmental factors that influence fish microbiota. To identify factors that explain microbial diversity patterns in a geographical subset of marine fish, we analyzed the microbiota (gill tissue, skin mucus, midgut digesta and hindgut digesta) from 101 species of Southern California marine fishes, spanning 22 orders, 55 families and 83 genera, representing ~25% of local marine fish diversity. We compare alpha, beta and gamma diversity while establishing a method to estimate microbial biomass associated with these host surfaces. We show that body site is the strongest driver of microbial diversity while microbial biomass and diversity is lowest in the gill of larger, pelagic fishes. Patterns of phylosymbiosis are observed across the gill, skin and hindgut. In a quantitative synthesis of vertebrate hindguts (569 species), we also show that mammals have the highest gamma diversity when controlling for host species number while fishes have the highest percent of unique microbial taxa. The composite dataset will be useful to vertebrate microbiota researchers and fish biologists interested in microbial ecology, with applications in aquaculture and fisheries management.
Programmable ferroelectric bionic vision hardware with selective attention for high-precision image classification
Authors: Yu Rengjian , He Lihua , Gao Changsong , Zhang Xianghong , Li Enlong , Guo Tailiang , Li Wenwu , Chen Huipeng
Published: November 2022

Selective attention is an efficient processing strategy to allocate computational resources for pivotal optical information. However, the hardware implementation of selective visual attention in conventional intelligent system is usually bulky and complex along with high computational cost. Here, programmable ferroelectric bionic vision hardware to emulate the selective attention is proposed. The tunneling effect of photogenerated carriers are controlled by dynamic variation of energy barrier, enabling the modulation of memory strength from 9.1% to 47.1% without peripheral storage unit. The molecular polarization of ferroelectric P(VDF-TrFE) layer enables a single device not only multiple nonvolatile states but also the implementation of selective attention. With these ferroelectric devices are arrayed together, UV light information can be selectively recorded and suppressed the with high current decibel level. Furthermore, the device with positive polarization exhibits high wavelength dependence in the image attention processing, and the fabricated ferroelectric sensory network exhibits high accuracy of 95.7% in the pattern classification for multi-wavelength images. This study can enrich the neuromorphic functions of bioinspired sensing devices and pave the way for profound implications of future bioinspired optoelectronics.
A Glb1-2A-mCherry reporter monitors systemic aging and predicts lifespan in middle-aged mice
Authors: Sun Jie , Wang Ming , Zhong Yaqi , Ma Xuan , Sun Shimin , Xu Chenzhong , Peng Linyuan , Li Guo , Zhang Liting , Liu Zuojun , Ai Ding , Liu Baohua
Published: November 2022

The progressive decline of physiological function and the increased risk of age-related diseases challenge healthy aging. Multiple anti-aging manipulations, such as senolytics, have proven beneficial for health; however, the biomarkers that label in vivo senescence at systemic levels are lacking, thus hindering anti-aging applications. In this study, we generate a Glb1+/m‒Glb1-2A-mCherry (GAC) reporter allele at the Glb1 gene locus, which encodes lysosomal β-galactosidase—an enzyme elevated in tissues of old mice. A linear correlation between GAC signal and chronological age is established in a cohort of middle-aged (9 to 13 months) Glb1+/m mice. The high GAC signal is closely associated with cardiac hypertrophy and a shortened lifespan. Moreover, the GAC signal is exponentially increased in pathological senescence induced by bleomycin in the lung. Senolytic dasatinib and quercetin (D + Q) reduce GAC signal in bleomycin treated mice. Thus, the Glb1-2A-mCherry reporter mice monitors systemic aging and function decline, predicts lifespan, and may facilitate the understanding of aging mechanisms and help in the development of anti-aging interventions.
Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation
Authors: Petroff John T. , Dietzen Noah M. , Santiago-McRae Ezry , Deng Brett , Washington Maya S. , Chen Lawrence J. , Trent Moreland K. , Deng Zengqin , Rau Michael , Fitzpatrick James A. J. , Yuan Peng , Joseph Thomas T. , Hénin Jérôme , Brannigan Grace , Cheng Wayland W. L.
Published: November 2022

Pentameric ligand-gated ion channels (pLGICs) mediate synaptic transmission and are sensitive to their lipid environment. The mechanism of phospholipid modulation of any pLGIC is not well understood. We demonstrate that the model pLGIC, ELIC (Erwinia ligand-gated ion channel), is positively modulated by the anionic phospholipid, phosphatidylglycerol, from the outer leaflet of the membrane. To explore the mechanism of phosphatidylglycerol modulation, we determine a structure of ELIC in an open-channel conformation. The structure shows a bound phospholipid in an outer leaflet site, and structural changes in the phospholipid binding site unique to the open-channel. In combination with streamlined alchemical free energy perturbation calculations and functional measurements in asymmetric liposomes, the data support a mechanism by which an anionic phospholipid stabilizes the activated, open-channel state of a pLGIC by specific, state-dependent binding to this site.
mTOR inhibition attenuates chemosensitivity through the induction of chemotherapy resistant persisters
Authors: Liu Yuanhui , Azizian Nancy G. , Sullivan Delaney K. , Li Yulin
Published: November 2022

Chemotherapy can eradicate a majority of cancer cells. However, a small population of tumor cells often survives drug treatments through genetic and/or non-genetic mechanisms, leading to tumor recurrence. Here we report a reversible chemoresistance phenotype regulated by the mTOR pathway. Through a genome-wide CRISPR knockout library screen in pancreatic cancer cells treated with chemotherapeutic agents, we have identified the mTOR pathway as a prominent determinant of chemosensitivity. Pharmacological suppression of mTOR activity in cancer cells from diverse tissue origins leads to the persistence of a reversibly resistant population, which is otherwise eliminated by chemotherapeutic agents. Conversely, activation of the mTOR pathway increases chemosensitivity in vitro and in vivo and predicts better survival among various human cancers. Persister cells display a senescence phenotype. Inhibition of mTOR does not induce cellular senescence per se, but rather promotes the survival of senescent cells through regulation of autophagy and G2/M cell cycle arrest, as revealed by a small-molecule chemical library screen. Thus, mTOR plays a causal yet paradoxical role in regulating chemotherapeutic response; inhibition of the mTOR pathway, while suppressing tumor expansion, facilitates the development of a reversible drug-tolerant senescence state.
Patient uptake and outcomes following pharmacist-initiated referrals to general practitioners for asthma review
Authors: Serhal Sarah , Krass Ines , Emmerton Lynne , Bereznicki Bonnie , Bereznicki Luke , Bosnic-Anticevich Sinthia , Saini Bandana , Billot Laurent , Armour Carol
Published: November 2022

Uptake and outcomes of pharmacist-initiated general practitioner (GP) referrals for patients with poorly controlled asthma were investigated. Pharmacists referred at-risk patients for GP assessment. Patients were categorized as action takers (consulted their GP on pharmacist’s advice) or action avoiders (did not action the referral). Patient clinical data were compared to explore predictors of uptake and association with health outcomes. In total, 58% of patients (n = 148) received a GP referral, of whom 78% (n = 115) were action takers, and 44% (n = 50) reported changes to their asthma therapy. Patient rurality and more frequent pre-trial GP visits were associated with action takers. Action takers were more likely to have an asthma action plan (P = 0.001) at month 12, and had significantly more GP visits during the trial period (P = 0.034). Patient uptake of pharmacist-initiated GP referrals was high and led to GP review and therapy changes in patients with poorly controlled asthma.
Combining MRI and clinical data to detect high relapse risk after the first episode of psychosis
Authors: Solanes Aleix , Mezquida Gisela , Janssen Joost , Amoretti Silvia , Lobo Antonio , González-Pinto Ana , Arango Celso , Vieta Eduard , Castro-Fornieles Josefina , Bergé Daniel , Albacete Auria , Giné Eloi , Parellada Mara , Bernardo Miguel ,   PEPs group (collaborators), Bioque Miquel , Morén Constanza , Pina-Camacho Laura , Díaz-Caneja Covadonga M. , Zorrilla Iñaki , Corres Edurne Garcia , De-la-Camara Concepción , Barcones Fe , Escarti María José , Aguilar Eduardo Jesus , Legido Teresa , Martin Marta , Verdolini Norma , Martinez-Aran Anabel , Baeza Immaculada , de la Serna Elena , Contreras Fernando , Bobes Julio , García-Portilla María Paz , Sanchez-Pastor Luis , Rodriguez-Jimenez Roberto , Usall Judith , Butjosa Anna , Salgado-Pineda Pilar , Salvador Raymond , Pomarol-Clotet Edith , Radua Joaquim
Published: November 2022

Detecting patients at high relapse risk after the first episode of psychosis (HRR-FEP) could help the clinician adjust the preventive treatment. To develop a tool to detect patients at HRR using their baseline clinical and structural MRI, we followed 227 patients with FEP for 18–24 months and applied MRIPredict. We previously optimized the MRI-based machine-learning parameters (combining unmodulated and modulated gray and white matter and using voxel-based ensemble) in two independent datasets. Patients estimated to be at HRR-FEP showed a substantially increased risk of relapse (hazard ratio = 4.58, P < 0.05). Accuracy was poorer when we only used clinical or MRI data. We thus show the potential of combining clinical and MRI data to detect which individuals are more likely to relapse, who may benefit from increased frequency of visits, and which are unlikely, who may be currently receiving unnecessary prophylactic treatments. We also provide an updated version of the MRIPredict software.
COVID-19 in Switzerland real-time epidemiological analyses powered by EpiGraphHub
Authors: Coelho Flávio Codeço , Araújo Eduardo Corrêa , Keiser Olivia
Published: November 2022

Here we present the design and results of an analytical pipeline for COVID-19 data for Switzerland. It is applied to openly available data from the beginning of the epidemic in 2020 to the present day (august 2022). We analyzed the spatio-temporal patterns of the spread of SARS-CoV2 throughout the country, applying Bayesian inference to estimate population prevalence and hospitalization ratio. We also developed forecasting models to characterize the transmission dynamics for all the country’s cantons taking into account their spatial correlations in COVID incidence. The two-week forecasts of new daily hospitalizations showed good accuracy, as reported herein. These analyses’ raw data and live results are available on the open-source EpiGraphHub platform to support further studies.
Health risk assessment and source apportionment of potentially toxic metal(loid)s in windowsill dust of a rapidly growing urban settlement, Iran
Authors: Madadi Reyhane , Mohamadi Sedigheh , Rastegari Mohammad , Karbassi Abdolreza , Rakib Md. Refat Jahan , Khandaker Mayeen Uddin , Faruque Mohammad Rashed Iqbal , Idris Abubakr M.
Published: November 2022

Rapid industrialization and urbanization have resulted in environmental pollution and unsustainable development of cities. The concentration of 12 potentially toxic metal(loid)s in windowsill dust samples (n = 50) were investigated from different functional areas of Qom city with the highest level of urbanization in Iran. Spatial analyses (ArcGIS 10.3) and multivariate statistics including Principal Component Analysis and Spearman correlation (using STATISTICA-V.12) were adopted to scrutinize the possible sources of pollution. The windowsill dust was very highly enriched with Sb (50 mg/kg) and Pb (1686 mg/kg). Modified degree of contamination (mCd) and the pollution load indices (PLIzone) indicate that windowsill dust in all functional areas was polluted in the order of industrial > commercial > residential > green space. Arsenic, Cd, Mo, Pb, Sb, Cu, and Zn were sourced from a mixture of traffic and industrial activities, while Mn in the dust mainly stemmed from mining activities. Non-carcinogenic health risk (HI) showed chronic exposure of Pb for children in the industrial zone (HI = 1.73). The estimations suggest the possible carcinogenic risk of As, Pb, and Cr in the dust. The findings of this study reveal poor environmental management of the city. Emergency plans should be developed to minimize the health risks of dust to residents.
Elemental, fatty acid, and protein composition of appendicoliths
Authors: Prieto James M. , Wang Andrew W. , Halbach Jonathan , Cauvi David M. , Day James M. D. , Gembicky Milan , Ghassemian Majid , Quehenberger Oswald , Kling Karen , Ignacio Romeo , DeMaio Antonio , Bickler Stephen W.
Published: November 2022

Appendicoliths are commonly found obstructing the lumen of the appendix at the time of appendectomy. To identify factors that might contribute to their formation we investigated the composition of appendicoliths using laser ablation inductively coupled plasma mass spectroscopy, gas chromatography, polarized light microscopy, X-ray crystallography and protein mass spectroscopy. Forty-eight elements, 32 fatty acids and 109 human proteins were identified within the appendicoliths. The most common elements found in appendicoliths are calcium and phosphorus, 11.0 ± 6.0 and 8.2 ± 4.2% weight, respectively. Palmitic acid (29.7%) and stearate (21.3%) are the most common fatty acids. Some stearate is found in crystalline form—identifiable by polarized light microscopy and confirmable by X-ray crystallography. Appendicoliths have an increased ratio of omega-6 to omega-3 fatty acids (ratio 22:1). Analysis of 16 proteins common to the appendicoliths analyzed showed antioxidant activity and neutrophil functions (e.g. activation and degranulation) to be the most highly enriched pathways. Considered together, these preliminary findings suggest oxidative stress may have a role in appendicolith formation. Further research is needed to determine how dietary factors such as omega-6 fatty acids and food additives, redox-active metals and the intestinal microbiome interact with genetic factors to predispose to appendicolith formation.
CA125 as a predictor of endometrial cancer lymphovascular space invasion and lymph node metastasis for risk stratification in the preoperative setting
Authors: Shawn LyBarger K. , Miller Hunter A. , Frieboes Hermann B.
Published: November 2022

Endometrial cancer (EC) is the most common malignancy of the female reproductive system. Cancer antigen 125 (CA125) is a serum tumor marker widely reported in EC patients, particularly those with poor prognostic factors such as grade 3 tumors, deep myometrial invasion, lymph node metastasis (LNM), and extra-uterine disease. This retrospective study stratifies pre-operative CA125 levels to evaluate odds ratios (OR) and relative risk (RR) between CA125 levels and the likelihood of +LNM, lymphovascular space invasion (LVSI), grade, and stage. Patient charts for women 18 years or older with a diagnosis of EC and pre-operative or within one week CA125 measurement from January 2000 to January 2015 at a regional hospital were reviewed. OR and RR were determined by unconditional maximum likelihood estimation for CA125 levels as the predictor with staging, grade, +LVSI and +LNM as outcomes. The largest increase in risk for patients having stage I/II/III disease was 52% greater (1.52-fold risk) while largest increase in risk for patients having stage III/IV disease was 67% greater (1.67-fold risk), both at CA125 ≥ 222U/ml. Patients with CA125 ≥ 122U/ml had significantly increased risk of +LNM, with maximum increase in risk of 98% (1.98-fold risk) at 222U/ml. Patients with CA125 ≥ 175U/ml had significantly increased risk of +LVSI, with maximum increase in risk of 39% (1.39-fold risk) at 222U/ml. This study shows that elevated CA125 levels correspond to increased stage, +LVSI, and +LNM in patients with EC.
Environmental impact of diets for dogs and cats
Authors: Pedrinelli Vivian , Teixeira Fabio A. , Queiroz Mariana R. , Brunetto Marcio A.
Published: November 2022

Food production is responsible for almost one-quarter of the environmental impact and, therefore, its importance regarding sustainability should not be overlooked. The companion animal population is increasing, and an important part of pet food is composed of ingredients that have a high environmental impact. This study aimed to evaluate the impact of dry, wet, and homemade pet diets on greenhouse gas emission, land use, acidifying emission, eutrophying emissions, freshwater withdrawals, and stress-weighted water use. The wet diets were responsible for the highest impact, and dry diets were the type of diet that least impacted the environment, with a positive correlation between the metabolizable energy provided by animal ingredients and the environmental impact. It is necessary to consider the environmental impact of pet food since it is significant, and the population of pets tends to increase.
PIV and CFD investigation of paddle flocculation hydrodynamics at low rotational speeds
Authors: Chatila Jean George , Danageuzian Hrair Razmig
Published: November 2022

In this study, flocculation hydrodynamics were evaluated by investigating the velocity field of turbulent flow experimentally and numerically, in a laboratory scale paddle flocculator. Turbulence that either promotes the particle aggregation or the breakage of flocs is complicated and has been considered and compared in this work using two turbulence models; namely, the SST k–ω and the IDDES. Results showed that IDDES provided very slight improvement as compared to SST k–ω, yielding the latter sufficient in accurately simulating the flow inside the paddle flocculator. A Goodness-of-Fit evaluation was adopted to study the convergence between PIV and CFD results, and to compare the results of the used CFD turbulence models. The study focused, as well, on the quantification of the slippage factor k, as 0.18 at low rotational speeds of 3 rpm and 4 rpm, and compared to conventional typical value of 0.25. This reduction of k from 0.25 to 0.18 yields around 27–30% increase in the power imparted to the fluid, and about 14% increase in velocity gradient (G). This implies that more mixing is provided than expected, and therefore, less energy is input and thus the electric consumption for the flocculation unit at a drinking water treatment plant could be potentially decreased.
Relationship between red blood cell aggregation and dextran molecular mass
Authors: Bosek Maciej , Ziomkowska Blanka , Pyskir Jerzy , Wybranowski Tomasz , Pyskir Małgorzata , Cyrankiewicz Michał , Napiórkowska Marta , Durmowicz Maciej , Kruszewski Stefan
Published: November 2022

The aim of this study was to investigate the aggregation of red blood cells (RBCs) suspended in dextran solution at various levels of molecular mass. Dextran solutions at molecular mass 40, 70, 100 and 500 kDa at concentration from 2 to 5 g/dL were used to suspend the RBCs. The radius and velocity of sedimenting RBC aggregates were investigated using image analysis. The radius and sedimentation velocity of aggregates increased initially, then decreased after achieving maxima. The maximal velocity of RBC aggregates showed a bell-shaped dependence on dextran molecular mass and concentration, whereas maximal radius showed monotonic increase with both factors. Difference between aggregate and solution density was estimated using aggregate radius and sedimentation velocity and dextran solution viscosity, and was consistent across most molecular mass and concentration levels. This allowed to calculate the porosity of aggregates and to show that it monotonically decreased with the increase in the solution density, caused by the increase in the dextran concentration. The results provide insight into the RBC aggregation process in solutions of proteins of different size, reflecting various pathological conditions. The currently reported data can be potentially applied to specific pathophysiological conditions giving an interpretation that is not yet fully discussed in the literature.
Health-related quality of life and clinical outcome after radiotherapy of patients with intracranial meningioma
Authors: Lisowski Dominik , Trömel Jannik , Lutyj Paul , Lewitzki Victor , Hartrampf Philipp E. , Polat Bülent , Flentje Michael , Tamihardja Jörg
Published: November 2022

This retrospective, single-institutional study investigated long-term outcome, toxicity and health-related quality of life (HRQoL) in meningioma patients after radiotherapy. We analyzed the data of 119 patients who received radiotherapy at our department from 1997 to 2014 for intracranial WHO grade I-III meningioma. Fractionated stereotactic radiotherapy (FSRT), intensity modulated radiotherapy (IMRT) or radiosurgery radiation was applied. The EORTC QLQ-C30 and QLQ-BN20 questionnaires were completed for assessment of HRQoL. Overall survival (OS) for the entire study group was 89.6% at 5 years and 75.9% at 10 years. Local control (LC) at 5 and 10 years was 82.4% and 73.4%, respectively. Local recurrence was observed in 22 patients (18.5%). Higher grade acute and chronic toxicities were observed in seven patients (5.9%) and five patients (4.2%), respectively. Global health status was rated with a mean of 59.9 points (SD 22.3) on QLQ-C30. In conclusion, radiotherapy resulted in very good long-term survival and tumor control rates with low rates of severe toxicities but with a deterioration of long-term HRQoL.
Hydrogen diffusion and its electrical properties variation as a function of the IGZO stacking structure
Authors: Noh Hee Yeon , Lee Woo-Geun , G. R. Haripriya , Cha Jung-Hwa , Kim June-Seo , Yun Won Seok , Lee Myoung-Jae , Lee Hyeon-Jun
Published: November 2022

The oxygen vacancies and hydrogen in oxide semiconductors are regarded as the primary sources of charge carriers and various studies have investigated the effect of hydrogen on the properties of oxide semiconductors. However, the carrier generation mechanism between hydrogen and oxygen vacancies in an a-IGZO semiconductor has not yet been clearly examined. In this study we investigated the effect of hydrogen and the variation mechanisms of electrical properties of a thin film supplied with hydrogen from the passivation layer. SiOx and SiNx, which are used as passivation or gate insulator layers in the semiconductor process, respectively, were placed on the top or bottom of an a-IGZO semiconductor to determine the amount of hydrogen penetrating the a-IGZO active layer. The hydrogen diffusion depth was sufficiently deep to affect the entire thin semiconductor layer. A large amount of hydrogen in SiNx directly affects the electrical resistivity of a-IGZO semiconductor, whereas in SiOx, it induces a different behavior from that in SiNx, such as inducing an oxygen reaction and O–H bond behavior change at the interface of an a-IGZO semiconductor. Moreover, the change in electrical resistivity owing to the contribution of free electrons could be varied based on the bonding method of hydrogen and oxygen.
Novel pruning and truncating of the mixture of vine copula clustering models
Authors: Alanazi Fadhah Amer
Published: November 2022

The mixture of the vine copula densities allows selecting the vine structure, the most appropriate type of parametric marginal distributions, and the pair-copulas individually for each cluster. Therefore, complex hidden dependence structures can be fully uncovered and captured by the mixture of vine copula models without restriction to the parametric shape of margins or dependency patterns. However, this flexibility comes with the cost of dramatic increases in the number of model parameters as the dimension increases. Pruning and truncating each cluster of the mixture model will dramatically reduce the number of model parameters. This paper, therefore, introduced the first pruning and truncating techniques for the model-based clustering algorithm using the vine copula model, providing a significant contribution to the state-of-the-art. We apply the proposed methods to a number of well-known data sets with different dimensions. The results show that the performance of the individual pruning and truncation for each model cluster is superior to an existing vine copula clustering model.
Self-rated health and chronic inflammation are related and independently associated with hospitalization and long-term mortality in the general population
Authors: Tavenier Juliette , Rasmussen Line Jee Hartmann , Tolstrup Janne , Petersen Janne , Sobocki Jakob , Pisinger Charlotta , Eugen-Olsen Jesper , Gamst-Jensen Hejdi
Published: November 2022

The subjective indicator of health self-rated health (SRH) and the chronic inflammation biomarker soluble urokinase plasminogen activator receptor (suPAR) are both robust predictors of healthcare use and mortality. However, the possible relationship between SRH and suPAR in the assessment of hospitalization and mortality risk is unknown. We used data from the Danish population-based Inter99 cohort to examine the association between SRH and suPAR and test their individual and combined associations with 2-year risk of acute hospitalization and 5- and 15-year mortality. SRH and serum suPAR levels were measured in 5490 participants (median age 45.1 years, 48.7% men). Poorer SRH was associated with elevated suPAR. In unadjusted analyses, SRH and suPAR were individually associated with higher risks of acute hospitalization and mortality, and both measures remained independently associated with higher risks of hospitalization and 15-year mortality after mutual adjustments. The association of suPAR with mortality was stronger in poorer SRH categories, and when combined, SRH and suPAR could identify different groups of individuals with increased risk of acute hospitalization and mortality. Both SRH and suPAR were independently associated with risk of acute hospitalization and mortality, and different combinations of the two measures could identify different groups of individuals at increased risk.