bluuebunny/crossref_metadata_2025 huggingface dataset:
Climate Change, Migration, and Vulnerability
Authors: Nakayama Mikiyasu , Drinkall Scott , Sasaki Daisuke
Published: December 2019

As global sea levels continue to rise, atoll countries—facing persistent and imminent risk—are expected to become source nations of climate migrants in the foreseeable future. This special issue features 10 academic articles, which examine if residents in Pacific atoll countries were, are, or will be ready to re-establish their livelihoods after relocation.

The topic of migration is akin to a kaleidoscope, with continuously evolving shapes and colors, necessitating a broad spectrum of approaches across various disciplines. The authors of these articles thus examined the topic through mathematics, civil engineering, cultural and disaster studies, economics, education, geography, international relations, language, law, sociology and politics. The methodologies applied range from policy analysis to structural equation modeling.

Migration driven by climate change takes place gradually, even over a few decades. Unlike forced migration due to causes such as war and conflict, future climate migrants have the short-term advantage of time to ready themselves for displacement from their homeland. Preparation prior to relocation may include enhancing one’s language or vocational skills.

One of the focal points of this special issue is therefore the preparedness of migrants, both past and future. Case studies were carried out across Fiji, Kiribati, the Marshall Islands, Micronesia, and the United States.

We also considered how migrants are received following resettlement, both in terms of legal instruments and assistance given by the public and private sectors. Case studies conducted in Austria and the United States address this aspect.

Yet another focus is to identify prevailing factors through which people develop their perceptions of climate change and its implications, for such perceptions are a driving force for migration. Case studies in Kiribati and the Marshall Islands contribute to this understanding.

We hope this special issue sharpens the vision of climate change and migration, and serves as a stepping stone for further research in the field.
Migration with Dignity: A Case Study on the Livelihood Transition of Micronesians to Portland and Salem, Oregon
Authors: Drinkall Scott , Leung Jackie , Bruch Carl , Micky Kapiolani , Wells Sandi ,   Environmental Law Institute 1730 M Street, NW #700, Washington, D.C. 20036, USA,   Micronesian Islander Community, Oregon, USA
Published: December 2019

The Pacific Islander population in the U.S. continues to grow, with the Portland-Salem, Oregon area serving as one of the largest communities, notably among those from the Micronesian region. Migrants emigrate for a variety of reasons including educational and employment opportunities, improved healthcare, and assisting family members. The purpose of this study is to better understand the transition of Micronesians – specifically Chuukese, Marshallese, and Palauans – to Oregon and to identify factors that help or hinder that transition. The study utilizes a Migration with Dignity framework, assessing reasons for emigration to the U.S., experienced quality of life, especially livelihoods, potential reasons for (not) returning to one’s home country, and barriers and facilitating factors for an improved quality of life in Oregon.
Higher Education and Destination of the Youth in the Republic of the Marshall Islands: Implication for Climate-Induced Migration
Authors: Yoshioka Nagisa , Taafaki Irene , McKay Yolanda ,   The Ocean Policy Research Institute, Sasakawa Peace Foundation 1-15-16 Toranomon, Minato, Tokyo 105-8524, Japan,   Marshall Islands Campus, The University of the South Pacific, Majuro, Republic of the Marshall Islands
Published: December 2019

Little is known about the extent to which climate change drives migration from the Pacific atoll nation of the Republic of the Marshall Islands (RMI). How and to what extent the youth of RMI aspire to migrate to other countries was investigated through a survey of 106 students at the Marshall Islands Campus of the University of the South Pacific (RMI-USP). While 44% of respondents indicated an aspiration to move abroad either for study or employment, and most students were well aware of the adverse effects of climate change, climate change was not cited as the primary reason or motivation for migration. Analysis of data in a second study explored the University’s tracking data of Foundation Year graduates from the RMI-USP Joint Education Program. This analysis found that students who have studied abroad are more likely to have the opportunity to either stay abroad or to migrate at some time after their studies.
A Platform for Multidisciplinary Research in Disaster Science Through Experiences from the 2011 Tohoku Earthquake and Tsunami
Authors: Imamura Fumihiko ,   Core Research Cluster of Disaster Science, Tohoku University 468-1 Aza-Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8572, Japan, Takakura Hiroki , Matsuzawa Toru , Ito Kiyoshi
Published: December 2019

Recent natural disasters, including the 2011 Tohoku earthquake and tsunami, have caused tremendous widespread damage and disruption around the world, and disaster risk reduction (DRR) has become a global priority. Tohoku University established a core research cluster, thus creating a new area of “disaster science” that consolidates four different science areas – practical, natural sciences, humanities, and social science – by adopting the disaster management cycle concept. It takes an inventory of research needs for science and technology applications in DRR and serves as a platform for discussions on strengthening multidisciplinary research on disaster science. This paper introduces the central idea driving the project and offers strategies to contribute to existing academic science and international society.
Three-Dimensional Measurement for Revitalization of Intangible Cultural Properties After Disasters
Authors: Fukuda Yu ,   Center for Northeast Asian Studies (CNEAS), Tohoku University 41 Kawauchi, Aoba, Sendai, Miyagi 980-8576, Japan
Published: December 2019

Various traditional festivals have taken place in most of the community in the coastal areas of the Tohoku region before the 2011 Great East Japan earthquake. Recent studies have revealed that reviving these festivals plays a crucial role for people to reconstruct a community life in the tsunami-affected area. Despite the importance of the intangible cultural properties, not only outfits used but also crafts to make those kits were swept away by the 2011 tsunami. Under this background, this research attempts to record the three-dimensional data of those materials used in festivals and folk performing arts. This project aims to construct the database of those props used for the intangible cultural properties and offer three-dimensional data to the disaster-affected area to rebuild their community life. Another goal of this explorative project is to create a methodology of three-dimensional measurement in the field of the disaster humanity science. By scanning cultural properties in disaster-prone areas not only in Japan but also in other countries, the project attempts to connect international networks to discuss the applicability of this method.
Effects of Methionine-Cysteine Amino Acid Supplementations in the Aflatoxin B1 Contaminated Diet on Broiler Production Performance
Authors: Purnamasari Listya , Agus Ali , Noviandi Cuk Tri
Published: December 2019

This research aimed to observe the interaction of methionine-cysteine amino acid supplementation to decrease the effect of aflatoxin B1 (AFB1) on diet against production performance of broiler chicken. A number of 240 mixed sex broiler chickens were treated in 9 treatments by factorial design 3 x 3 with methionine-cysteine amino acid (M+C) (75,100, dan 125%) factors and AFB1 levels (0, 200, dan 400 ppb). Variables observed were: Weight gain, feed consumption, and feed conversion ratio (FCR). The results showed that increased AFB1 content in diet from 0 to 400 ppb increased chicken body weight (P <0.05) in each age group. The high body weight was balanced with high feed consumption along with increased nutrient needs, mainly sulfuric amino acid (M+C) as the precursor of glutathione to eliminate toxic through conjugation reactions. The interaction effect was firstly occurred between M + C and AFB1 treatment (P <0.05). Meanwhile increased supplementation of M + C from 75 to 125% caused decreased feed consumption in each age group of chickens, but increased AFB1 levels further increased feed consumption (P<0.05). The interaction effect between the level of M + C and AFB1 contamination in diets on feed consumption were seen in 21-day-old chickens (P<0.05). FCR was also increased (P <0.05) with the reduction of M + C content in diet at 7 days old. The effect of AFB1 on diet and interaction between M + C and AFB1 on chicken FCR in this study was not significant in all age groups. It can be concluded from the current study that supplying methionine-cystine amino acid with 75, 100 and 125% in AFB1 contaminated diet of 0, 200 and 400 ppb improves the performance of broiler chicken production.
Diet with Concentrate Containing Durio zibethinus Murr Seed Meal: Nutrient Contents, Fatty Acid Profiles, In Vitro Characteristics, and Nutrient Digestibility in Dairy Cows
Authors: Sulistyowati Endang , Badarina Irma , Mujiharjo Sigit , Simbolon Tamrin , Purba Idop Rohani
Published: December 2019

This research was to evaluate concentrate diet containing Durio zibethinus seed meal (DSM) on nutrient contents, fatty acid profiles, in vitro characteristics, and nutrients digestibility in dairy cows. The experiment was arranged in Latin Square 4 x 4 design with 4 lactating dairy cows in 4 periods in 2 weeks for each period. The treatments were diets with concentrate containing ratios of rice bran and DSM,  DC 35/12.5 (35% of Rice bran+ 12.5% of DSM), DC 27.5/20 (27.5% of Rice bran+ 20% of DSM), DC 20/27.5 (20% of Rice bran+ 27.5% of DSM) and DC 12.5/35 (12.5% of Rice bran+ 35% of DSM). Data were analyzed using analysis of variance (Anova), if any significant difference among treatment means were found, will be further analyzed using Duncan Multiple Range Test (DMRT). Results showed that 20% of  DSM supplemented in concentrate improved nutrient contents of crude protein, ether extract, medium chain fatty acid (MCFA), long chain fatty acid (LCFA), polyunsaturated fatty acid (PUFA), unsaturated fatty acid (UFA), and n6/n3. In vitro dry matter digestibility, organic matter digestibility, N-NH3, and total VFA were high in concentrate containing 35% DSM. However, in vivo digestibility evaluation showed nutrient intakes were no differences among treatments. Nutrient digestibility were found higher in diet with concentrate containing 27.5% of DSM. There were three different optimal levels could be suggested, 20% of DSM (for nutrient and fatty acid content), 27.5% of DSM (for nutrient digestibility), and 35% of DSM (for in vitro characteristics).  Supported by previous milk production, it was concluded that the 27.5% of DSM was suggested to be applied in concentrate for dairy cows.
Nepoznati Šulek
Authors: Vignjević Jelena , Petrović Bernardina
Published: December 2019

Bogoslav Šulek poznat je ponajprije kao jezikoslovac, leksikograf i publicist. U njegovu se radu posebno ističe prinos znanstvenomu nazivlju na hrvatskom jeziku, pa ga se naziva utemeljiteljem hrvatskoga znanstvenoga nazivlja. Međutim, slabo je i nedostatno razmatran Šulekov prinos didaktici kao općoj teoriji školskoga poučavanja i učenja, a napose metodici početnoga čitanja na hrvatskom jeziku, o čem se raspravlja u ovom radu. Bogoslav je Šulek naime 1850. u Zagrebu tiskom Franje Župana objavio Naputak za one, koji uče čitati i Malu čitanku za početnike. U tima dvjema knjižicama, prvoj namijenjenoj učiteljima i roditeljima, a drugoj učenicima, Bogoslav Šulek predstavlja tadašnjoj hrvatskoj školskoj javnosti novu metodu podučavanja čitanja – „Lautir-Methode“ – po kojoj se čitanje uči tako da se izgovara i pamti glas slova, a ne njegov naziv. Šulekov metodički priručnik i čitanka u ovom su radu sagledani u kontekstu onodobne metodike početnoga čitanja na hrvatskom jeziku, čime se pokazala njihova uloga prekretnice u dotadašnjem načinu opismenjavanja.
Utjecaj popularnokulturne spektakularnosti na pojavnost novih likova u suvremenom hrvatskom dječjem romanu
Authors: Slunjski Kristina
Published: December 2019

Popularnokulturni utjecaji primjetni su u svim aspektima ljudskoga života pa tako i u umjetnosti. S obzirom na nedovoljnu istraženost utjecaja popularne kulture u kontekstu dječje književnosti, u radu se razmatra njezina interakcija sa suvremenim hrvatskim dječjim romanom. Točnije, interferencija popularne kulture i dječje romaneskne produkcije promatra se na korpusu od 12 dječjih romana objavljenih od 1970. godine, odnosno od vremena kada popularnokulturne silnice dobivaju na značenju u kontekstu postmodernističkih promjena. Elementi se popularne kulture u dječje romane podjednako unose namjerno, kako bi romaneskna produkcija bila zanimljiva dječjim recipijentima i kako bi je oni dobro prihvatili, ali i bez posebnih intencija autora, koji ih u svoja djela unose nehotice jer su i sami okruženi sadržajima popularne kulture. Pritom se u fokus stavlja pojavnost novih likova, konstrukata popularne kulture, čije je uvrštavanje u lepezu romanesknih likova dječje književnosti potaknuto najočitijim popularnokulturnim obilježjem – spektakularnošću. U radu se ponajprije detektiraju navedeni likovi, ali i načini na koje ih suvremena dječja romaneskna produkcija oblikuje.
Formation Mechanisms and Methods for Calculating Pollutant Emissions from Natural Gas Combustion Depending on the Burner Emission Class
Authors: Yarmolchick Yu. P.
Published: December 2019

The combustion of hydrocarbon fuels in the chambers of heat generating plants is one of the main sources of pollutant emissions. Environmental standards and rules that limit emissions are becoming more stringent and their implementation requires the introduction of advanced technologies and equipment. The main device in combustion systems are blow burners, the design of which largely determines the level of emission. The article considers factors that intensify the formation of normalized pollutants, provides global chemical reactions, various types of mechanisms, and kinetic schemes. Based on the analysis of modern methods for reducing harmful emissions, the most effective design solutions for mixing devices, nozzles and systems for distributing the flow of fuel and air supplied to combustion are determined. A comparative analysis of the methods and conditions for determining the emission class of the burner device is carried out depending on the selected units of measure, the coefficient of excess air (oxygen concentration in flue gases), air humidity and the initial composition of natural gas using examples of EU and EAC standards. The methodology for calculating the emissions of nitrogen oxides depending on the measurement conditions is given. The conversion factors for the values of pollutant emissions from the accepted units in the EU (mg/(kW×h)) into the units indicated according to the EAC environmental rules (mg/m3) taking into account the respectively normalized coefficient of excess air are obtained. As a result of the calculations, the types of burners were determined by emission classes corresponding to the applicable environmental standards and rules in the Republic of Belarus, depending on the heat output of the boiler plants.
First Record of Mint Leaf Beetle, Chrysolina herbacea (Duftschmid, 1825), (Coleoptera: Chrysomelidae) in Iraq
Authors: Al-Nadawi Fayhaa Abbood
Published: December 2019

The  insect is diagnosed and named by the National Center of Biotechnology Information (NCBI), USA as the Mint leaf Beetle Chrysolina herbacea alnadawi (Duftschmid, 1825), (Coleoptera: Chrysomelidae). The diagnosis was performed depending on the DNA analysis by 73% similarity with Chrysolina herbacea (Duftschmid, 1825) sequence, In the present study. It is recorded as a new insect pest on mint plant Mentha  puleguim (L,1753) (Lamiaceae). DNA analysis confirmend that it is recorded for the first time in Iraq and the Arab world as well as the Middle East. Those insects were observed initially during August 2017 in residential gardens of Al-Bonooq district in Baghdad / Iraq.
Effect of Bifidobacterium Probiotic in the Treatment of Giardiasis Infection in Mice
Authors: Abd AL-Khaliq Israa Mohammad
Published: December 2019

Metronidazole therapy is recommended in the treatment of giardiasis,athough some clinical reports mention the resistance to this drug from many pathogens. Many studies were applied to show the effect of probiotic to prevent or to heal diseases of gastrointestine, but only few is known about probiotic activity against infections of protozoa. This study aims to evaluate the efficiency of Bifidobacterium against infection with Giardia lamblia   in experimental mice. It was found that daily application of viable Bifidobacterium cells with a single dose (0.1ml∕mice∕day) significantly reduced the shedding of Giardia lamblia parasite cysts in feces, and infection completely disappeared at the day (15th) post inoculation with this probiotic.  Also, it was noticed that Giardia cysts were reduced in the group treated with metronidazole, and infection cured at day (17th) from treatment, while the control group showed shedding cysts of this parasite. Histopathologically, the effect of Bifidobacterium in vivo by gut cells modulation prevents the colonization of Giardia, leading to reduce the infection with this parasite.
Comparison between Biological Activities of Commercial and Synthesized Carbon Nanotubes by Flame Fragments Deposition Technique
Authors: Et al. Alwindawi
Published: December 2019

Carbon nanotubes (CNTs) were synthesized via liquefied petroleum gas (LPG) as precursor using flame fragments deposition (FFD) technique. In vitro, biological activates of carbon nanotubes (CNTs) synthesized by FFD technique were investigated. The physiochemical characterizations of synthesized CNTs are similar to other synthesized CNTs and to the standard sample. Pharmaceutical application of synthesized CNTs was studied via conjugation and adsorption with different types of medicines as promote groups. The conjugation of CNTs was performed by adsorption the drugs such as sulfamethoxazole (SMX) and trimethoprim (TMP) on CNTs depending on physical properties of both bonded parts. The synthesized CNTs almost have the same performance in antibiotic activity compared with standard sample of CNTs (commercial CNTs).The products were effective antibiotic in the treatment as resistant bacteria, may higher concentration of CNTs would have antibacterial activity on multi-drug resistant bacteria such as Acinetobacter and also on resistant E.coli. The bioactivity synthesized and standard samples of CNTs were almost the same against different types of bacteria.
Primary Colors Red, Yellow, and Blue Use as Self-Cleaning Paints with Layer of Titanium Dioxide
Authors: Al-Shaikh Hussin Suma H.
Published: December 2019

Transparent nano- coating was prepared by Sol-Gel method from titanium dioxide TiO2 which has the ability to self-cleaning coating used for hospitals, laboratories, and places requiring permanent sterilization. Three primary colors are selected (red, blue, and yellow) as preliminary study to the effect of these colors on the nano-coating. Three traditional oil paints color were used as base, then coated by a layer of TiO2-Sol and deposited on the paints. The optical properties of TiO2-Sol were measured; the maximum absorption wavelength at (λmax=387 nm), the refractive index (n=1.4423) and the energy band gap (Eg=3.2 eV). The structure properties found by X-ray diffraction of TiO2-Sol illustrated that TiO2-Sol is polycrystalline nanoparticle have anatase phase also the morphological properties measured by Scanning Electron Microscopy (SEM) obetained the average grain size of TiO2-Sol was (50.427 nm). Self-cleaning properties measured by tensiometer dives. The best color gave the highest response to self-cleaning is the yellow color where the contact angle before exposure to UV ( = 101.47º ,at t = 0 min) and after exposure over time ( = 1.75º ,at t = 50 min), thus the water sheet of the surface and remove all contaminants.
Symmetric- Based Steganography Technique Using Spiral-Searching Method for HSV Color Images
Authors: Ogla Raheem Abdul Sahib
Published: December 2019

Steganography is defined as hiding confidential information in some other chosen media without leaving any clear evidence of changing the media's features. Most traditional hiding methods hide the message directly in the covered media like (text, image, audio, and video). Some hiding techniques leave a negative effect on the cover image, so sometimes the change in the carrier medium can be detected by human and machine. The purpose of suggesting hiding information is to make this change undetectable. The current research focuses on using complex method to prevent the detection of hiding information by human and machine based on spiral search method, the Structural Similarity Index Metrics measures are used to get the accuracy and quality of the retrieved image and to improve its perceived quality.

The values of information measures are calculated through practical experiments of (perceptibility, robustness, capacity) by using interpolation technique and structural similarity measures. Experimental results show that the use of these measures (PSNR, MSE, and SSIM) has improved the image quality by 87% and has produced values of PSNR (38-41 dB), MSE = 0.6537 and SSIM= 0.8255. The results also demonstrate a remarkable progress in the field of hiding information and the increasing difficulty of detecting it by humans and machines.
Predictors of clinical outcomes after cardiac resynchronization therapy in patients ≥75 years of age: a retrospective cohort study
Authors: Champ-Rigot Laure , Cornille Anne-Laure , Ollitrault Pierre , Pellissier Arnaud , Chequel Mathieu , Legallois Damien , Milliez Paul
Published: December 2019

Background: Cardiac resynchronization therapy has been shown to benefit selected patients with heart failure and reduced ejection fraction. Older patients have been underrepresented in randomized trials. This study was conducted to determine whether predictive factors for cardiac resynchronization therapy outcomes differ in patients older and younger than 75 years of age.
Methods: Consecutive patients who received a cardiac resynchronization device cardiac resynchronization therapy between 2013 and 2016 in our center were retrospectively included in this cohort study. The primary endpoint was cardiac resynchronization therapy effectiveness, which was defined as survival for one year with both no heart failure hospitalization and improvement by one or more NYHA class. The secondary endpoints were mortality, complications, and device therapies.
Results: Among the 243 patients included, 102 were ≥75 years old. Cardiac resynchronization therapy effectiveness was observed in 70 patients (50%) <75 years old and in 48 patients (47%) ≥75 years old (p=0.69). NYHA class ≥III (OR=6.02; CI95% [1.33-18.77], p=0.002) was a predictive factor for cardiac resynchronization therapy effectiveness only in the ≥75-year-old group, while atrial fibrillation was independently negatively associated with the primary endpoint in the <75-year-old group (OR=0.28; CI95% [0.13-0.62], p=0.001). The one-year mortality rate was 14%, with no difference between age groups. Rescue cardiac resynchronization therapy and atrial fibrillation were independent predictive factors for mortality in both age groups. Eighty-two complications occurred in 45 patients (19%), with no difference between groups. Defibrillator use and QRS duration were independent predictive factors for complications in both age groups. There was no difference between groups considering device therapies.
Conclusion: At one year, cardiac resynchronization therapy response is not compromised by patient age. In older patients, highly symptomatic individuals with NYHA class ≥III have better outcomes after cardiac resynchronization therapy.

KEYWORDS: Resynchronization therapy; heart failure; aged; treatment outcome
Transcriptome Analysis Reveals Mechanism Underlying the Differential Intestinal Functionality of Laying Hens in the Late Phase and Peak Phase of Production
Authors: Wang Weiwei , Wang Jing , Zhang Haijun , Wu Shugeng , Qi Guanghai
Published: December 2019

Background: The compromised performance of laying hens in the late phase of production relative to the peak production was thought to be associated with the impairment of intestinal functionality, which plays essential roles in contributing to their overall health and production performance. In the present study, RNA sequencing was used to investigate differences in the expression profile of intestinal functionality-related genes and associated pathways between laying hens in the late phase and peak phase of production.
Results : A total of 104 upregulated genes with 190 downregulated genes were identified in the ileum (the distal small intestine) of laying hens in the late phase of production compared to those at peak production. These upregulated genes were found to be enriched in little KEGG pathway, however, the downregulated genes were enriched in the pathways of PPAR signaling pathway, oxidative phosphorylation and glutathione metabolism. Besides, these downregulated genes were mapped to several GO clusters in relation to lipid metabolism, electron transport of respiratory chain, and oxidation resistance. Similarly, there were lower activities of total superoxide dismutase, glutathione S-transferase and Na + /K + -ATPase, and reductions of total antioxidant capacity and ATP level, along with an elevation in malondialdehyde content in the ileum of laying hens in the late phase of production as compared with those at peak production.
Conclusions: The intestine of laying hens in the late phase of production were predominantly characterized by a disorder of lipid metabolism, concurrent with impairments of energy production and antioxidant property. This study uncovers the mechanism underlying differences between the intestinal functionality of laying hens in the late phase and peak phase of production, thereby providing potential targets for the genetic control or dietary modulation of intestinal hypofunction of laying hens in the late phase of production.
Applied Anatomy of Pelvic Lymph Nodes and Its Clinical Significance for Prostate Cancer:A Single-Center Cadaveric Study
Authors: Jia-Jun Chen , Zai-Sheng Zhu , Yi-Yi Zhu , Hong-Qi Shi
Published: December 2019

Background Pelvic lymph node dissection (PLND) is one of the most important steps in radical prostatectomy (RP). Not only can PLND provide accurate clinical staging to guide treatment after prostatectomy but PLND can also improve the prognosis of patients by eradicating micro-metastases. However, reports of the number of pelvic lymph nodes have generally come from incomplete dissection during surgery, there is no anatomic study that assesses the number and variability of lymph nodes. Our objective is to assess the utility of adopting the lymph node count as a metric of surgical quality for the extent of lymph node dissection during RP for prostate cancer by conducting a dissection study of pelvic lymph nodes in adult male cadavers. Methods All 30 adult male cadavers underwent pelvic lymph node dissection (PLND), and the lymph nodes in each of the 9 dissection zones were enumerated and analyzed. Results A total of 1267 lymph nodes were obtained. The number of lymph nodes obtained by local PLND was 4-22 (14.1±4.5), the number obtained by standard PLND was 16-35 (25.9±5.6), the number obtained by extended PLND was 17-44 (30.0±7.0), and the number obtained by super-extended PLDN was 24-60 (42.2±9.7). Conclusions There are substantial inter-individual differences in the number of lymph nodes in the pelvic cavity. These results have demonstrated the rationality and feasibility of adopting lymph node count as a surrogate for evaluating the utility of PLND in radical prostatectomy, but these results need to be further explored.
Genome-wide association study (GWAS) for morphological and yield-related traits in an oil palm hybrid (Elaeis oleifera x Elaeis guineensis) population
Authors: Osorio Jaime , Garzón Gina , Delgadillo Paola , Bastidas Silvio , Moreno Leidy , Enciso Felix , Cornejo Omar , Barrero Luz Stella
Published: December 2019

Background The genus Elaeis has two species of economic importance for the oil palm agroindustry: Elaeis oleifera (O), native to the Americas, and Elaeis guineensis (G), native to Africa. This work provides to our knowledge, the first association mapping study in an interspecific OxG oil palm population, which shows tolerance to pests and diseases, high oil quality, and acceptable fruit bunch production. Results Using genotyping-by-sequencing (GBS), we identified a total of 3,776 single nucleotide polymorphisms (SNPs) that were used to perform a genome-wide association analysis (GWAS) in 378 OxG hybrid population for 10 agronomic traits. Twelve genomic regions (SNPs) were located near candidate genes implicated in multiple functional categories, such as tissue growth, cellular trafficking, and physiological processes. Conclusions We provide new insights on genomic regions that mapped on candidate genes involved in plant architecture and yield. These potential candidate genes need to be confirmed for future targeted functional analyses. Associated markers to the traits of interest may be valuable resources for the development of marker-assisted selection in oil palm breeding. Keywords: Association mapping, Elaeis guineensis , Elaeis oleifera , genotyping-by-sequencing, plant architecture, yield.
Magnetic Resonance Enterography, Colonoscopy, and Fecal Calprotectin correlate in colonic Crohn’s Disease
Authors: Somwaru Alexander S. , Khanijow Vikesh , Katabathina Venkat S.
Published: December 2019

Background: Fecal calprotectin (FCP), magnetic resonance enterography (MRE), and colonoscopy are complementary biometric tests that are used to assess patients with Crohn’s Disease (CD). While prior studies have evaluated the association between combinations of these tests, no study has established a correlation between all three: FCP, MRE, and colonoscopy. We prospectively investigated if there is correlation between these three tests, which may result in improved clinical outcomes that can then be used to streamline patient monitoring and treatment modification.
Methods: 156 patients with colonic CD were prospectively examined between March 2017 and December 2018. FCP levels, MRE, and colonoscopy were assessed in parallel on all 156 patients. Clinical CD activity was measured with the Crohn’s Disease Activity Index (CDAI). CD activity with FCP was measured with a quantitative immunoassay. CD activity on MRE was measured with the Magnetic Resonance Index of Activity (MaRIA). CD activity on colonoscopy was measured with the Crohn’s Disease Endoscopic Index of Severity (CDEIS).
Results: 112 patients (72%) had active disease (Crohn’s Disease Activity Index > 150) and 44 patients (28%) were in clinical remission disease (Crohn’s Disease Activity Index < 150). FCP levels, MaRIA, and CDEIS are highly correlated with positive and significant Pearson and Spearman coefficients, respectively (P < 0.0001), in univariate analyses. Regression analysis (multivariate analyses) demonstrates significant, positive correlation between FCP and MaRIA (r = 1.07, P < 0.0001) and between FCP and CDEIS (r = 0.71, P = 0.03), and between
MaRIA and CDEIS (r = 0.63, P = 0.01).
Conclusions: FCP levels significantly correlate with the degree of active inflammation in patients with colonic Crohn’s Disease. Improved clinical results may be achieved by using a biometric strategy that incorporates FCP, colonoscopy, and MRE together. This strategy may in-turn be used in the future to streamline monitoring disease activity and adjustment of therapy to improve long term patient outcomes.
Efficacy and safety of two Ayurvedic dosage forms for Allergic rhinitis: Study protocol for an open-label randomized controlled trial
Authors: Dahanayake JM , Perera Pathirage Kamal , Galappaththy P , Samaranayake D
Published: December 2019

Background: Allergic rhinitis (AR) is an immune response of the nasal mucosa to airborne allergens and involves nasal congestion, watery nasal discharge, itching of the nose and sneezing. The symptoms of allergic rhinitis may significantly affect a patient’s quality of life and can be associated with conditions such as fatigue, headache, cognitive impairment and sleep disturbances. Various complementary and alternative medicine treatments have been used for this condition in clinical practice. The Ayurveda system of medicine is the most common complementary medicine system practiced in Sri Lanka. The aim of this study is to examine the efficacy and safety of a decoction used in traditional Ayurveda for allergic rhinitis and it’s ready to use freeze dried formulation in comparison to an antihistamine over a period of 4 weeks on relief of symptoms in allergic rhinitis. Study design: This is a three arm, open label, non-inferiority, randomized controlled clinical trial enrolling patients with AR. Tamalakyadi decoction containing 12 ingredients (TMD12), used in traditional Ayurveda and its freeze dried formulation are the test products. The efficacy and safety of the two Ayurvedic dosage forms will be tested against the antihistamine loratidine Patients with symptoms of AR will be allocated randomly into the 3 arms after a 1 week run-in period and the medications will be given orally for 28 days. Total Nasal symptom Score (TNSS) of the patients will be used as the primary efficacy endpoint. TNSS will be recorded and compared between the 3 arms prior to visit 1, at the end of 28 days, end of the and second months of follow up. Symptom scores of daytime nasal symptoms, night time nasal symptoms, non-nasal symptoms and Health Related Quality of Life questionnaire are used as secondary end points. Discussion: This clinical trial will be able to provide evidence based scientific data on Ayurvedic dosage form, TMD12 and the freeze-dried formulation in the treatment of allergic rhinitis. This trial is expected to develop capacity to scientifically evaluate various Ayurvedic treatments that are claimed to have efficacy in treatment of various disease conditions. Trial registration:ISRCTN18149439 (06 May 2019) Keywords: Allergic rhinitis, Ayurvedic dosage forms, Tamalakyadi decoctions, Randomized controlled trial
Prevalence and contributing factors of Birth asphyxia among the neonates delivered at Nigist Eleni Mohammed Memorial Teaching Hospital, Southern Ethiopia: A cross-sectional study
Authors: Abdo Ritbano Ahmed , Halil Hassen Mosa , Kebede Biruk Assefa , Anshebo Abebe Alemu , Gejo Negeso Gebeyehu
Published: December 2019

Background: Birth asphyxia is a major contributor to neonatal mortality worldwide. In Ethiopia, birth asphyxia remains a severe condition that leads to significant mortality and morbidity. This study aims to assess the prevalence and contributing factors of birth asphyxia among the neonates delivered at the Nigist Eleni Mohammed Memorial Teaching Hospital, Southern Ethiopia. Methods: This hospital-based cross-sectional study was carried out on 279 participants using the systematic sampling method during June 1- 30, 2019. Data were collected using a pretested structured interviewer administered questionnaire, check list and chart review, which was used to retrieve medical information and mother’s test results that could not be captured by the interview. Data were entered into EpiData (version 3.1) and analyzed using SPSS software (version 24). Multivariable regression analysis was used to identify the association between the independent variables and outcome variable with a 95% confidence interval (CI). Result: The overall prevalence of birth asphyxia among newborns was found to be 15.1%. Factors that were significantly associated with birth asphyxia included mothers aged ≥ 35 (AOR=6.4; 95% CI = 2.0-20.5), primigravida (AOR=5.1; 95% CI =2.0-13.3), prolonged second stage of labor (AOR=4.6; 95%CI =1.6-13.3), preterm birth (AOR=4.7; 95% CI =1.5-14.1), meconium stained amniotic fluid (AOR=7.5; 95% CI =2.5-21.4) and tight nuchal (AOR=3.1; 95% CI =1.2- 9.3). Conclusion: Birth asphyxia is still prevalent in the study setting. The obtained findings indicated that the mothers aged , being primigravida, preterm birth, meconium stained amniotic fluid and tight nuchal were the factors associated with birth asphyxia. The results of this study show the need for better maternal care, creating awareness about contributing factors of birth asphyxia to the maternity health professionals, careful monitoring of labor, and identifying and taking proper measures that could help in reducing the occurrence of birth asphyxia.
Combining physical therapy and cognitive behavioral therapy techniques to improve balance confidence and community participation in people with unilateral transtibial amputation who use lower limb prostheses: a study protocol for a randomized sham-control clinical trial
Authors: Bourque McKenzie , Schneider Kristin L , Calamari John E , Reddin Christopher , Stachowiak Aaron , Major Matthew J , Duncan Chad , Muthukrishnan Sri Ranjini , Rosenblatt Noah J
Published: December 2019

Background : Low balance confidence is a prevalent yet overlooked issue among people who use lower limb prostheses (LLP) that can diminish community integration and quality of life. There is a critical need to develop rehabilitation programs that specifically target balance confidence in people who use LLP. Previous research has shown that multicomponent interventions including cognitive-behavioral therapy (CBT) techniques and exercise are feasible and effective for improving balance confidence in older adults. Therefore, a cognitive behavioral-physical therapy (CBPT) intervention was developed to target balance confidence and increase community integration in people who use LLP. Methods : This randomized control trial will recruit sixty people who use LLP with low balance confidence. Participants will be randomized to the CBPT intervention condition or control condition. Discussion : The trial is designed to test the effects of the CBPT intervention on balance confidence and functional mobility in lower limb prosthesis users by examining self-reported and objective measures of community integration and quality of life. The trial will also examine the relationship between changes in balance confidence and changes in community integration following participation in CBPT intervention. Additionally, through participant feedback, researchers will identify opportunities to improve intervention efficacy.
Comparison of radiological changes after single- position versus dual- position for lateral interbody fusion and pedicle screw fixation
Authors: Hiyama Akihiko , Katoh Hiroyuki , Sakai Daisuke , Sato Masato , Tanaka Masahiro , Watanabe Masahiko
Published: December 2019

Background: There have been few comparisons between dual positions, which require a position change, and a single position, which does not require position change, and it is not clear whether there is a difference in indirect decompression achieved by the two procedures. Therefore, the purpose of this study was to compare perioperative and radiographic outcomes following lateral lumbar interbody fusion (LLIF) in two cohorts of patients who underwent surgery in a single position or dual position.

Methods: This study involved 45 patients who underwent indirect decompression at 68 levels, with LLIF and percutaneous pedicle screw (PPS) fixation for lumbar degenerative spondylolisthesis with spinal canal stenosis. Patient demographics and perioperative data were compared between two groups: patients who remained in the lateral decubitus position for pedicle screw fixation (SP group) and those turned to the prone position (DP group).

Results: A total of 26 DP and 19 SP patients were analyzed. The operation time was approximately 31 min longer for the DP group (129.7 ± 36.0 min) than for the SP group (98.4 ± 41.3 min, P < 0.01). We also evaluated the pre- and postoperative image measurements, there was no significant difference for lumbar lordosis, segmental disc angle, slipping length, and disc height between the groups. The CSA of the dural sac (DP group, from 55.3 to 78.4 mm2; SP group, from 54.7 to 77.2 mm2) and central canal diameter (DP group, from 5.9 to 7.9 mm; SP group, from 5.6 to 7.7 mm) was significantly larger after surgery in both groups. However, there were no statistically significant differences between the two groups (P = 0.684).

Conclusions: SP surgery could reduce the average surgery time by about 31 min. We found that the effect of indirect decompression by SP-PPS fixation following LLIF was considered to be a useful technique with no difference in dural sac enlargement or disc angle obtained compared with DP-PPS fixation.
Anesthetics and long-term survival after cancer surgery—total intravenous versus volatile anesthesia: a retrospective study
Authors: Hong Boohwi , Lee Sunyeul , Kim Yeojung , Lee Minhee , Youn Ann Misun , Rhim Hyun , Hong Seok-Hwan , Kim Yoon-Hee , Yoon Seok-Hwa , Lim Chaeseong
Published: December 2019

Background: Intravenous anesthesia has been reported to have a favorable effect on the prognosis of cancer patients. This study was performed to analyze data regarding the relation between anesthetics and the prognosis of cancer patients in our hospital.

Methods: The medical records of patients who underwent surgical resection for gastric, lung, liver, colon, and breast cancer between January 2006 and December 2009 were reviewed. Depending on the type of anesthetic, it was divided into total intravenous anesthesia (TIVA) or volatile inhaled anesthesia (VIA) group. The 5-year overall survival outcomes were analyzed by log-rank test. Cox proportional hazards modeling was used for sensitivity.

Results: The number of patients finally included in the comparison after propensity matching came to 729 in each group. The number of surviving patients at 5 years came to 660 (90.5%) in the TIVA and 673 (92.3%) in the VIA. The type of anesthetic did not affect the 5-year survival rate according to the log-rank test (P = 0.21). Variables associated with a significant increase in the hazard of death after multivariable analysis were male sex and metastasis at surgery.

Conclusions: There were no differences in 5-year overall survival between two groups in the cancer surgery.
Evidence on the effect of position change on pressure ulcer among hospitalized adult patients in Ethiopia: systematic review and meta-analysis
Authors: shiferaw wondimeneh shibabaw , Aynalem Yared Asmare , Akalu Tadesse Yirga
Published: December 2019

Background Pressure ulcers (PU) aﬀect millions of people worldwide and always occur over bony areas of the body where pressure and tissue distortion is greatest. The national pooled prevalence of pressure ulcer remains unknown. Hence, this meta-analysis aimed to determine the effect of position change on pressure ulcer among hospitalized clients in Ethiopia. Methods Studies were retrieved through search engines in PubMed, Scopus, WHO afro library, Google Scholar, Africa journal online, PsycINFO and web-science following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). Analysis was done using STATA version 14 software. Heterogeneity between-study was checked using the I 2 and examined a potential publication bias by visual inspection of the funnel plot and Egger’s regression test statistic. The random-effect model was fitted to estimate the summary effects, odds ratios (ORs), and 95% confidence interval (CIs) across studies. Results Out of the reviewing 401 studies, 7 studies fulfilled the inclusion criteria and were included in the meta-analysis. The estimated pooled prevalence of pressure ulcer in Ethiopia was 11.7% (95% CI (7.28, 16.13%)). Based on the subgroup analysis, the estimated magnitude of pressure ulcer was 15.89% (95% CI: 35.34, 54.04) among studies their sample size were greater than or equals to 250. Those clients who have position change during hospitalization were 82% less likely to develop pressure ulcer [(OR: 0.18 (95% CI (0.07, 0.46)) than their counter part. Conclusion The overall prevalence of pressure ulcer in Ethiopia was relatively high. Position change of the client during hospitalization had paramount benefit to reduce the burden of pressure ulcer. Therefore, policymakers (federal minister of health) could give special attention to minimize the magnitude of pressure ulcer, and to improve the overall quality of healthcare service. Further, meta-analysis study could be conducted to identify individual and health care service related factors to the occurrence of pressure ulcer.
Prevalence and Genotype Distribution of Genital Human Papillomavirus Infection in Female Sex Workers in the World: a Systematic Review and Meta-Analysis
Authors: Farahmand Mohammad , Monavari Seyed Hamidreza , Moghoofei Mohsen , Kiani Seyed Jalal , Tavakoli Mehdi , Tavakoli Ahmad
Published: December 2019

Background: Female sex workers (FSWs) are amongst the most susceptible groups to acquire Human papillomavirus (HPV) infection and consequently, to develop cervical intraepithelial neoplasia and cervical cancer. This is the first systematic review and meta-analysis to provide estimates of the pooled prevalence of HPV infection and distribution of HPV types among FSWs across the world. Methods: Five computerized databases were searched for relevant studies published since the inception date of databases to September 2019. The pooled HPV prevalence was calculated by the random effect model described by DerSimonian-Laird. Subgroup analysis was performed to identify the probable source of heterogeneity. The meta-analysis was performed using the “Metaprop” function in the R package Meta. Results: Sixty-six studies involving 22938 FSWs from 34 countries were included in this meta-analysis, and the pooled HPV prevalence was 41.97% (95% confidence interval (CI): 37.99%-46.05%). HPV-16 (10.42%, 95% CI: 8.61%–12.55%), HPV-52 (7.76%, 95% CI: 5.75%–10.39%), and HPV-53 (6.09%, 95% CI: 4.55%–8.12%) were the most common high-risk HPV types identified among FSWs. Geographically, the highest and the lowest prevalence of HPV were obtained from Hungary (82.35%, 95%CI: 65.90%–91.85%) and Mexico (13.30%, 95%CI: 1.67%–58.06%), respectively. Conclusion: Due to the high prevalence of HPV infection, particularly with high-risk types, FSWs have a great susceptibility to the development of cervical and vaginal cancers. Furthermore, they can transmit their infection to their clients, which may result in a high prevalence of HPV and incidence of HPV-associated malignancies among the general population.