bluuebunny/crossref_metadata_2025 huggingface dataset:
Cover Image, Volume 12, Issue 5
Authors: Keil Tobias W. M. , Baldassi Domizia , Merkel Olivia M.
Published: August 2020

The cover image is based on the Focus Article TH2‐cell targeted pulmonary siRNA delivery for the treatment of asthma by Tobias W. M. Keil, Domizia Baldassi and Olivia M. Merkel. https://doi.org/10.1002/wnan.1634.

image
In recreational alpine skiing, the ACL is predominantly injured in all knee injuries needing hospitalisation
Authors: Posch Markus , Schranz Alois , Lener Manfred , Tecklenburg Katja , Burtscher Martin , Ruedl Gerhard
Published: August 2020

Purpose

The knee joint still represents the most frequent anatomical injury location accounting for about one-third of all injuries in recreational alpine skiers. However, comprehensive information on current knee injury patterns in this populations is sparse.

Methods

During the winter seasons 2016/17 and 2019/20, this retrospective questionnaire-based study was conducted in an Austrian sportclinic situated in a large ski area. Among a cohort of 282 recreational skiers (51.8% females), all injuries were diagnosed by the use of magnetic resonance imaging. Additionally, data were recorded on anthropometric characteristics, the perceived speed at the moment of injury, type of fall, physical fitness, self-reported skill level and risk-taking behaviour.

Results

The anterior cruciate ligament (ACL) was injured in all knee injuries recorded. Of the total study sample, 64.5% (n = 182) were ACL injuries with concomitant injuries and about 35.5% (n = 100) were isolated ACL injuries, not involving any other structures of the knee joint. In general, most common concomitant injury diagnoses among ACL-injured recreational alpine skiers were injuries of the medial collateral ligament (MCL) (n = 92, 50.5%), medial meniscus (MM) (n = 73, 40.1%) and lateral collateral ligament (LCL) (n = 41, 22.5%). No significant differences regarding additionally recorded characteristics were found between ACL-injured individuals with concomitant injuries and those with isolated ACL injury.

Conclusions

Whereas, before the introduction of carving skis, the MCL was reported being the most common injured part of the knee, currently, the majority of knee injuries are ACL injuries accompanied by injury of other knee joint structures, i.e. the MCL, MM and LCL.

Level of evidence

Level III.
Development of a LC-MS/MS method using stable isotope dilution for the quantification of individual B6 vitamers in fruits, vegetables, and cereals
Authors: Bachmann Thomas , Maurer Andrea , Rychlik Michael
Published: August 2020

Vitamin B6comprises an important set of molecules tightly interwoven with the human amino acid, fatty acid, and carbohydrate metabolism. Analytical methods striving for the quantification of individual B6vitamers so far mostly rely on methods based on HPLC in combination with fluorescence detection, but their application encounters multiple difficulties due to the chemical divergence of the single vitamers. The present study describes the development of a method based on LC-MS/MS and stable isotope dilution assay (SIDA) for the simultaneous quantification of five vitamers (PN, PL, PM, PMP, and PNG) of the B6group in food samples. [13C3]-PN, [13C3]-PL, and [13C6]-PNG were applied as internal standards for the analysis of PN, PL, and PNG. PM and PMP were quantified via matrix-matched calibration referring to [13C3]-PN. The developed method was validated using starch matrix. The limits of detection and quantification ranged from 0.0028 to 0.02 mg/kg and from 0.0085 to 0.059 mg/kg, respectively, for all analytes. Calculated recoveries varied from 92 to 111%. Intra-injection precisions ranged from 0 to 9%, inter-day precisions from 4 to 10%, and intra-day precisions from 4 to 10%. A total of 14 plant-based food samplesincludingfruits, vegetables, and cereals were examined for their content of vitamin B6using the validated method. Furthermore, the first quantitation of PNG without enzymatic steps or divergent internal standards was undertaken utilizing LC-MS/MS and SIDA.
Head-down tilt bed rest with or without artificial gravity is not associated with motor unit remodeling
Authors: Attias Julia , Grassi Andrea , Bosutti Alessandra , Ganse Bergita , Degens Hans , Drey Michael
Published: August 2020

Purpose

The objective of this study was to assess whether artificial gravity attenuates any long-duration head-down 60 bed rest (HDBR)-induced alterations in motor unit (MU) properties.

Methods

Twenty-four healthy participants (16 men; 8 women; 26–54 years) underwent 60-day HDBR with (n = 16) or without (n = 8) 30 min artificial gravity daily induced by whole-body centrifugation. Compound muscle action potential (CMAP), MU number (MUNIX) and MU size (MUSIX) were estimated using the method of Motor Unit Number Index in the Abductor digiti minimi and tibialis anterior muscles 5 days before (BDC-5), and during day 4 (HDT4) and 59 (HDT59) of HDBR.

Results

The CMAP, MUNIX, and MUSIX at baseline did not change significantly in either muscle, irrespective of the intervention (p > 0.05). Across groups, there were no significant differences in any variable during HDBR, compared to BDC-5.

Conclusion

Sixty days of HDBR with or without artificial gravity does not induce alterations in motor unit number and size in the ADM or TA muscles in healthy individuals.
Diffusion–reaction compartmental models formulated in a continuum mechanics framework: application to COVID-19, mathematical analysis, and numerical study
Authors: Viguerie Alex , Veneziani Alessandro , Lorenzo Guillermo , Baroli Davide , Aretz-Nellesen Nicole , Patton Alessia , Yankeelov Thomas E. , Reali Alessandro , Hughes Thomas J. R. , Auricchio Ferdinando
Published: August 2020

The outbreak of COVID-19 in 2020 has led to a surge in interest in the research of the mathematical modeling of epidemics. Many of the introduced models are so-calledcompartmental models, in which the total quantities characterizing a certain system may be decomposed into two (or more) species that are distributed into two (or more) homogeneous units called compartments. We propose herein a formulation of compartmental models based on partial differential equations (PDEs) based on concepts familiar to continuum mechanics, interpreting such models in terms of fundamental equations of balance and compatibility, joined by a constitutive relation. We believe that such an interpretation may be useful to aid understanding and interdisciplinary collaboration. We then proceed to focus on a compartmental PDE model of COVID-19 within the newly-introduced framework, beginning with a detailed derivation and explanation. We then analyze the model mathematically, presenting several results concerning its stability and sensitivity to different parameters. We conclude with a series of numerical simulations to support our findings.
Economic landslide susceptibility under a socio-economic perspective: an application to Umbria Region (Central Italy)
Authors: Donnini Marco , Modica Marco , Salvati Paola , Marchesini Ivan , Rossi Mauro , Guzzetti Fausto , Zoboli Roberto
Published: August 2020

An accurate understanding of physical and socio-economic effects of landslides is fundamental to develop more refined risk management, mitigation strategies and land use policies. In this paper we develop a measure to consider the interconnection between physical and economic exposure, i.e. what we call the economic landslide susceptibility, namely the probability of landslide occurrence in an area weighted for its socio-economic exposure considering the real-estate market values. The economic landslide susceptibility is estimated through a method designed for large areas that we applied to the Umbria Region (Central Italy). The method makes use of landslide susceptibility maps and a real estate market value map for any given area under analysis. The innovative concept of economic landslide susceptibility (that is de facto an ex ante landslide cost assessment) may be interpreted as the potential loss that an area might suffer in terms of its propensity for landslides. Useful applications of the proposed method lie in a better territorial management and in the land use planning.
Non-metric Propositional Similarity
Authors: Paseau A. C.
Published: August 2020

The idea that sentences can be closer or further apart in meaning is highly intuitive. Not only that, it is also a pillar of logic, semantic theory and the philosophy of science, and follows from other commitments about similarity. The present paper proposes a novel way of comparing the ‘distance’ between two pairs of propositions. We define ‘$$p_1$$

p
1

is closer in meaning to $$p_2$$

p
2

than $$p_3$$

p
3

is to $$p_4$$

p
4

’ and thereby give a precise account of comparative propositional similarity facts. Notably, our definition eschews metric assumptions, which are unrealistic in most applications of interest.
Revealing the nucleation kinetics of primary Si particles in hypereutectic Al–Si alloys under the influence of P inoculation
Authors: Xu Yijiang , Deng Yun , Casari Daniele , Mathiesen Ragnvald H. , Liu Xiangfa , Li Yanjun
Published: August 2020

A quantitative study on the kinetics of nucleation of primary Si particles (PSPs), especially under the effect of P inoculation, during isothermal melt solidification of hypereutectic Al–Si(–Cu) alloys has been realized for the first time by using a unique micro-focus in situ X-radiography method, which is impossible by synchrotron X-radiography or tomography methods. The nucleation undercooling and nucleation rate of PSPs have been measured. Besides, TP-1 type solidification test has been carried out. It is found that nucleation undercooling of PSPs is reduced, while nucleation rate and number density of PSPs is increased significantly by P inoculation. Moreover, the influence of cooling rate on the nucleation kinetics of PSPs in the P inoculated alloy was investigated in situ. It is observed that higher cooling rate has the influence of increasing the peak nucleation rate and extending the nucleation temperature ranges of PSPs, in terms of earlier nucleation at lower undercooling and nucleation stopping at higher undercooling, which results in higher number density of PSPs. The decrease in minimum nucleation undercooling with increasing cooling rate in the P inoculated alloy is unexpected, which has been attributed to the extremely slow growth rate of faceted Si crystal on AlP substrates under low undercooling.
Plastic or glass: a new environmental assessment with a marine litter indicator for the comparison of pasteurized milk bottles
Authors: Stefanini Roberta , Borghesi Giulia , Ronzano Anna , Vignali Giuseppe
Published: August 2020

Purpose

Today plastic is the most used material for food packaging, but its incorrect disposal is creating environmental issues to oceans, soil and air. Someone believes that the solution is to ban plastic and substitute it with glass packaging. Is it the right choice? This study aims at comparing the environmental impact of bottles made of PET, R-PET, non-returnable glass and returnable glass in order to understand which is the most environmental friendly packaging solution.

Methods

A literature analysis on the environmental impact of glass and PET bottles is carried out, taking into account their production, transport and disposal phase. Then, an environmental assessment of PET, R-PET, glass and returnable glass bottles, used to package 1 l of pasteurized milk, has been carried out using the life cycle assessment methodology and a new indicator. Inventory data were provided by an important milk processing and packaging factory located in Italy. Results were estimated using some relevant impact categories of the ReCiPe 2016 MidPoint (H) method, then a marine litter indicator (MLI) has been proposed in order to evaluate the polluting potential of milk bottles dispersed into the Mediterranean Sea.

Results and discussion

LCA results show that R-PET bottle gives the lowest contribution to global warming, stratospheric ozone depletion, terrestrial acidification, fossil resource scarcity, water consumption and human carcinogenic toxicity, followed by PET bottle, returnable glass bottle, and finally non-returnable glass bottle. Glass is the worst packaging option because of high energy demand in the bottle production and its weight and in the transport phase. Some improvements can be obtained with returnable glass, but even if we consider that a bottle could be reused eight times, results are not comparable to the PET or R-PET bottles used only once. However, according to the MLI, returnable glass bottles become the first option, because a lot of plastic bottles could potentially be dispersed into the sea.

Conclusions

The substitution of plastic with glass does not help to reduce the GWP and others LCI categories, while could contribute to reduce the marine litter: overall it is important to dispose correctly packaging materials, investing in recycling and reusing. In particular, great improvements can be obtained using bottles made with recycled materials, as R-PET. In conclusion, it is necessary to disadvantage waste dispersion, giving incentives to returnable packaging and raising people awareness of environmental problems.
“Hey, We Can Do This Together”: Findings from an Evaluation of a Multi-sectoral Community Coalition
Authors: Realmuto Lindsey , Weiss Linda , Masseo Patrick , Madondo Kumbie , Kumar Rashi , Beane Susan , Pagán José A.
Published: August 2020

Multi-sectoral coalitions focused on systemic health inequities are commonly promoted as important mechanisms to facilitate changes with lasting impacts on population health. However, the development and implementation of such initiatives present significant challenges, and evaluation results are commonly inconclusive. In an effort to add to the evidence base, we conducted a mixed-methods evaluation of the Claremont Healthy Village Initiative, a multi-sectoral partnership based in the Bronx, New York City. At an organizational level, there were positive outcomes with respect to expanded services, increased access to resources for programs, improved linkages, better coordination, and empowerment of local leaders—all consistent with a systemic, community building approach to change. Direct impacts on community members were more difficult to assess: perceived access to health and other services improved, while community violence and poor sanitation, which were also priorities for community members, remained important challenges. Findings suggest significant progress, as well as continued need.
Respiratorische Ereigniserkennung unter nichtinvasiver Beatmung (NIV) in Abhängigkeit von der genutzten Flowmessung
Authors: Maarouf Adnan , Domanski Ulrike , Schröder Maik , Franke Karl-Josef , Nilius Georg
Published: August 2020

Hintergrund

Beim chronisch hyperkapnischem Atemversagen stellt die nächtliche nichtinvasive Beatmung (NIV) die Standardtherapie dar. Die Einstellung auf die NIV erfordert jedoch viel Erfahrung. Nur eine Polysomnografie (PSG) im Schlaflabor ermöglicht die genaue Analyse von residualen Obstruktionen der oberen Atemwege, zentralen Apnoen, Triggerfehlfunktionen und Leckagen. Die Flowmessung unter NIV ist technisch jedoch nicht einfach, insbesondere da normierte Schnittstellen zur Einbindung der Respiratoren in die PSG fehlen.

Ziel der Arbeit

Vergleich eines Druck‑/Flow-Monitors mit den Signalen aus den Schnittstellen der Respiratoren bezüglich der Erkennung sowohl von Apnoen/Hypopnoen als auch von NIV-spezifischen Ereignissen in der PSG.

Methoden

Retrospektiv wurden 20 Aufzeichnungen von Patienten unter NIV, die unter einem standardisierten Protokoll aufgezeichnet worden waren, erneut verblindet ausgewertet. Es erfolgte ein Vergleich der Auswertung dreier verschiedener Verfahren der Flowmessung (effortbasiert, Staudruckmessung, Schnittstelle) hinsichtlich der Häufigkeit von respiratorischen Ereignissen.

Ergebnisse

Durch eine einfach zu integrierende Staudruckmessung mittels Druck‑/Flow-Monitor waren signifikant weniger Ereignisse diagnostizierbar, als wenn der Flow über die Abdomen- und Thoraxgurte oder über die Schnittstelle zu den Respiratoren ermittelt wurde. Auch die NIV-induzierten Ereignisse wie Fehltriggerungen oder Leckagen ließen sich nur mittels der Schnittstelle zuverlässig erkennen.

Schlussfolgerung

Eine Messung des Flows mit einem Standard Druck‑/Flow-Monitor bietet keine ausreichend nachvollziehbaren Ergebnisse. Eine Einbindung des Beatmungsgeräts in die PSG über eine Schnittstelle ist daher zu fordern.
Application of a physics-based lumped parameter model to evaluate reservoir parameters during CO2 storage
Authors: Raziperchikolaee Samin , Mishra Srikanta
Published: August 2020

Evaluating reservoir performance could be challenging, especially when available data are only limited to pressures and rates from oil field production and/or injection wells. Numerical simulation is a typical approach to estimate reservoir properties using the history match process by reconciling field observations and model predictions. Performing numerical simulations can be computationally expensive by considering a large number of grids required to capture the spatial variation in geological properties, detailed structural complexity of the reservoir, and numerical time steps to cover different periods of oil recovery. In this work, a simplified physics-based model is used to estimate specific reservoir parameters during CO2 storage into a depleted oil reservoir. The governing equation is based on the integrated capacitance resistance model algorithm. A multivariate linear regression method is used for estimating reservoir parameters (injectivity index and compressibility). Synthetic scenarios were generated using a multiphase flow numerical simulator. Then, the results of the simplified physics-based model in terms of the estimated fluid compressibility were compared against the simulation results. CO2 injection data including bottom hole pressure and injection rate were also gathered from a depleted oil reef in Michigan Basin. A field application of the simplified physics-based model was presented to estimate above-mentioned parameters for the case of CO2 storage in a depleted oil reservoir in Michigan Basin. The results of this work show that this simple lumped parameter model can be used for a quick estimation of the specific reservoir parameters and its changes over the CO2 injection period.
A Generic Method for Estimating and Smoothing Multispecies Biodiversity Indicators Using Intermittent Data
Authors: Freeman Stephen N. , Isaac Nicholas J. B. , Besbeas Panagiotis , Dennis Emily B. , Morgan Byron J. T.
Published: August 2020

Biodiversity indicators summarise extensive, complex ecological data sets and are important in influencing government policy. Component data consist of time-varying indices for each of a number of different species. However, current biodiversity indicators suffer from multiple statistical shortcomings. We describe a state-space formulation for new multispecies biodiversity indicators, based on rates of change in the abundance or occupancy probability of the contributing individual species. The formulation is flexible and applicable to different taxa. It possesses several advantages, including the ability to accommodate the sporadic unavailability of data, incorporate variation in the estimation precision of the individual species’ indices when appropriate, and allow the direct incorporation of smoothing over time. Furthermore, model fitting is straightforward in Bayesian and classical implementations, the latter adopting either efficient Hidden Markov modelling or the Kalman filter. Conveniently, the same algorithms can be adopted for cases based on abundance or occupancy data—only the subsequent interpretation differs. The procedure removes the need for bootstrapping which can be prohibitive. We recommend which of two alternatives to use when taxa are fully or partially sampled. The performance of the new approach is demonstrated on simulated data, and through application to three diverse national UK data sets on butterflies, bats and dragonflies. We see that uncritical incorporation of index standard errors should be avoided.

Supplementary materials accompanying this paper appear online.
The reliability characteristics of the REFLECT rubric for assessing reflective capacity through expressive writing assignments: A replication study
Authors: Grierson Lawrence , Winemaker Samantha , Taniguchi Alan , Howard Michelle , Marshall Denise , Zazulak Joyce
Published: August 2020

Introduction The medical education community has implemented writing exercises that foster critical analysis and nurture reflective capacity. The REFLECT rubric (Wald et al. 2012) was developed to address the challenge of assessing these written reflections. The objective of this replication work is to explore the reproducibility of the reliability characteristics presented by the REFLECT developers.

Methods Five raters evaluated narratives written by medical students and experienced clinicians using the REFLECT rubric. Reliability across rubric domains was determined via intraclass correlation coefficient and internal consistency was determined via Cronbach’s alpha.

Results Intraclass coefficients demonstrated poor reliability for ratings across all tool criteria (0.350–0.452) including overall ratings of narratives (0.448). Moreover, the internal consistency between scale items was also poor across all criteria (0.529–0.621).

Discussion We did not replicate the reliability characteristics presented in the original REFLECT article. We consider these findings with respect to the contextual differences that existed between our study and the Wald and colleagues study, pointing particularly at the possible influence that repetitive testing and refinement of the tool may have had on their reviewers’ shared understanding of its use. We conclude with a discussion about the challenges inherent to reductionist approaches to assessing reflection.
Signal Ambiguity and Misinterpretation of Fetal Heart Rate: A Report of Two Cases and an Overview of Suspicious Patterns
Authors: Ramadan Mohamad K. , Yamout Walaa , Kharroubi Mariam , Malas Abir , Khazaal Janoub , Yared Georges , Badr Dominique A.
Published: August 2020

Electronic Fetal Heartrate Monitoring (EFHM) is the standard method for fetal well-being surveillance used during labor and delivery. There are, however, situations when tracings displayed by the EFHM are ambiguous and misleading. We present two cases where the Maternal Heart Rate (MHR) artefacts were mistaken for Fetal Heart Rate (FHR). In the first case, MHR masked the severity of fetal distress and caused a delayed and inappropriate management with subsequent poor neonatal outcome. In the second case, MHR was misinterpreted as FHR causing embarrassment of the birth attendants upon delivery of a dead macerated newborn. FHR should initially and continuously be verified as the actual origin of the signal displayed on the EFHM before any intervention is undertaken. Understanding the EFHM patterns produced by FHR or MHR and the utilization of modern EFHMs that apply concomitant recording and displaying of MHR and FHR can avert problems associated with signal ambiguity.
The Association Between the Social Determinants of Health and HIV Control in Miami-Dade County ZIP Codes, 2017
Authors: Rojas Dayana , Melo Anamarie , Moise Imelda K. , Saavedra Jorge , Szapocznik José
Published: August 2020

Background

There were 28,055 people living with HIV (PLWH) in Miami-Dade County (MDC) in 2017; 40.1% was either out of care or was not virally suppressed (uncontrolled HIV). The purpose of this study was to determine the association between the social determinants of health (SDOH) and the number of persons with uncontrolled HIV in MDC.

Setting

This cross-sectional study included PLWH 15 and older with uncontrolled HIV in MDC, 2017. Data on PLWH’s viral load, age, gender, mode of HIV transmission, and race/ethnicity were aggregated to the ZIP code level. All five SDOH per HealthyPeople 2020 were represented: economic stability, education, social and community context, health and healthcare, and neighborhood and built environment.

Methods

Descriptive analyses on all study variables and a principal component analysis on the SDOH variables were performed. To account for overdispersion, multivariate negative binomial regressions were run while controlling for confounders and testing for significant interactions.

Results

The results of the regression analysis indicated that an increase in Factor 1 (economic stability, education, and health and healthcare determinants) was associated with a statistically significant increase in the number of PLWH with uncontrolled HIV. Additionally, we found a significant interaction between Factor 1 and White race. Among persons of low socioeconomic status, White race is associated with a reduction in PLWH with uncontrolled HIV.

Conclusions

These results suggest that reducing poverty and increasing education and rates of health insurance should result in significant reductions in PLWH with uncontrolled HIV. These results have the potential to influence future policy, interventions for retention, adherence, and continuity of care to improve suppression rates in MDC.
Some computations on the characteristic variety of a line arrangement
Authors: Papini Oscar , Salvetti Mario
Published: August 2020

We find monodromy formulas for line arrangements that are fibered with respect to the projection from one point. We use them to find 0-dimensional translated components in the first characteristic variety of the arrangement "Equation missing" determined by a regular n-polygon and its diagonals. We also find new 1-dimensional translated components which generalize the well-known case of the $$B_3$$

B
3

-deleted arrangement.
The Limits of Authoritarian International Law
Authors: Mallat Chibli
Published: August 2020

Tom Ginsburg's concept of “authoritarian international law” (AIL) is as important as the one it references, Thomas Franck's “right to democratic governance.” It underlines how the promise carried by Franck was betrayed in the bitter turn of history that ended the emerging hope for democracy ruling all nations in the world after 1989. This hope had developed by fits and starts as the slow fulfilment of the Kantian project for “perpetual peace” amongst a world federation of democratic republics on which the League of Nations and the United Nations were built. To the now-universal acknowledgment of the grave domestic setbacks to human rights and democracy, Ginsburg's article adds an account of the international setbacks which followed. Its chief importance is in raising the question of the emergent authoritarian traits of international law in the wake of these setbacks. With my appreciation of Ginsburg's formidable treatment, including a title that will mark, like Franck's, an important moment in the field, I will challenge some of his conclusions and offer counterpoints in the present essay. In particular, I will (1) suggest the irrelevance of the three “evils of AIL”; (2) highlight the significance of 2006 as the date when AIL started rising; (3) emphasize the importance of U.S. isolationism in the rise of AIL; and (4) argue that the better investment to counter that rise is in nonviolence.
Dangerous Work, Intention, and the Ethics of Hazard Pay
Authors: Bailey Adam D.
Published: August 2020

Is offering hazard pay ethically permissible when the pay premium is the only reason that a dangerous job is accepted? Robert C. Hughes argues that it is not. Central to his argument is the claim that in such cases, workers intend the foreseeable risks of harm as a means to the pay premium. Herein I question the plausibility of this claim and then develop a conception of the concept of means sufficient to make it plausible. By so doing, I provide support for Hughes’s stringent position.
Bleomycin for Head and Neck Venolymphatic Malformations: A Systematic Review
Authors: Finitsis Stephanos , Faiz Khunsa , Linton Janice , Shankar Jai Jai Shiva
Published: August 2020

Background:

Venolymphatic malformations are rare benign vascular lesions of the head and neck. Sclerotherapy has become the first-line therapy of these lesions with bleomycin being a sclerosing agent commonly used.

Purpose:

To perform a systematic review of the published literature to synthesize evidence on the safety and efficacy of bleomycin for the treatment of head and neck venolymphatic malformations.

Data sources:

A systematic review of the literature (January 1995–May 2019) was performed in PubMed, Embase, and Cochrane Library databases to identify studies on sclerotherapy of venolymphatic malformations of the head and neck.

Study selection:

A total of 32 studies with participants met the inclusion criteria among which 1121 patients were included in the systematic review.

Data analysis:

Two reviewers independently screened and extracted data and assessed the risk of bias. The primary outcome was the subjective or objective reduction of lesion size as well as minor and major complications.

Data synthesis:

The bleomycin/pingyangmycin sclerotherapy achieved subjective or objective lesion size reduction in 96.3% (95% CI 94.1%–98.5%) of patients. Minor complications were observed in 16.2% and major complications in 1.1%.

Conclusion:

Bleomycin is a highly effective treatment of venolymphatic malformations of the head and neck with a low rate of major adverse events. This study represents an update on the “available” evidence, but only low-to-moderate quality studies were available.

Limitations:

This study reviewed 32 studies performed in different parts of the world, but there was heterogeneity of the study designs and interventions.
The Effect of a Simulated Fire Disaster Psychological First Aid Training Program on the Self-efficacy, Competence, and Knowledge of Mental Health Practitioners
Authors: Park Jung Suk , Choi Yun-Jung
Published: August 2020

Objective:

This study developed a simulation program using standardized patients for the training of mental health practitioners in psychological first aid and evaluated its effect on learners’ self-efficacy and psychological first aid performance competence and knowledge. The simulation used in this program was of a fire disaster.

Methods:

Thirty participants were randomly assigned to an experimental group, a comparison group, and a control group. The experimental group participated in simulation training after attending a two-hour psychological first aid lecture. The comparison group was given only the two-hour lecture and the control group was given a psychological first aid handout to study individually. The results of pre- and post-intervention questionnaires were then statistically analyzed.

Results:

The participants’ self-efficacy, performance competency, and knowledge improved in all groups, and there were some statistically significant differences between the three groups. The experimental group showed a greater improvement in self-efficacy and performance than the other groups.

Conclusions:

The psychological first aid simulation training program was effective in improving three qualities of mental health practitioners: self-efficacy, performance competency, and knowledge. Further research is required for the development of various learning scenarios for iterative psychological first aid education.
Public awareness of tetralogy of Fallot after Jimmy Kimmel Live! television episode: A cross-sectional analysis
Authors: Greiner Benjamin , Lee Abraham , Checketts Jake , Hartwell Micah
Published: August 2020

Background

Persons with rare disorders, such as tetralogy of Fallot, often feel socially isolated due to poor public awareness of the disorder. On 1 May 2017, Jimmy Kimmel aired a segment on Jimmy Kimmel Live! highlighting the impact of tetralogy of Fallot on his son and how the public can learn more about the disorder.

Methods

We tracked public interest in tetralogy of Fallot using Google Trends and Twitter after the episode and constructed an autoregressive integrated moving average algorithm to calculate search volumes had Kimmel not aired the episode.

Results

Google searches and the number of Tweets for tetralogy of Fallot increased by 3063.27% and 4672.62%, respectively, above expected.

Conclusions

Our findings indicate that television talk shows may represent strong outlets for increasing public awareness of rare disorders.
The construction of patent claims
Authors: Booton David
Published: August 2020

This paper highlights two recurring facets of the way UK courts approach the construction of patent claims: the adoption of methods typically applied to the interpretation of contracts and the recognition that immaterial variations not expressly claimed nevertheless fall within the scope of protection. Drawing on the normative implications arising out of Ronald Coase's paper on the problem of social cost, this paper argues that the patent system operates as a substitute for an explicit bargain between economically active entities operating in the market under which a duty is accepted by one party in return for acceptance of a burden of risk by the other. This perspective incorporates both the static costs and the dynamic benefits of the system and accords with the monopoly-profit-incentive theory most commonly advanced in support of the patent system. It is shown how the contemporary approach to claims construction is supported by the object of giving effect to the presumed intentions of the parties to this hypothetical bargain and that this underpins both the implication of terms which go beyond those expressly agreed to by parties to a contract and the construction of patent claims so as to embrace immaterial variations not expressly within their scope.
The impact of EPA and DHA on ceramide lipotoxicity in the metabolic syndrome
Authors: Walchuk Chelsey , Wang Yidi , Suh Miyoung
Published: August 2020

The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors including obesity, insulin resistance (IR) and dyslipidaemia. Consumption of a high-fat diet (HFD) enriched in SFA leads to the accumulation of ceramide (Cer), the central molecule in sphingolipid metabolism. Elevations in plasma and tissue Cer are found in obese individuals, and there is evidence to suggest that Cer lipotoxicity contributes to the MetS. EPA and DHA have shown to improve MetS parameters including IR, inflammation and hypertriacylglycerolaemia; however, whether these improvements are related to Cer is currently unknown. This review examines the potential of EPA and DHA to improve Cer lipotoxicity and MetS parameters including IR, inflammation and dyslipidaemiain vitroandin vivo. Current evidence from cell culture and animal studies indicates that EPA and DHA attenuate palmitate- or HFD-induced Cer lipotoxicity and IR, whereas evidence in humans is greatly lacking. Overall, there is intriguing potential for EPA and DHA to improve Cer lipotoxicity and related MetS parameters, but more research is warranted.
Mitigating Striga hermonthica parasitism and damage in maize using soybean rotation, nitrogen application, and Striga-resistant varieties in the Nigerian savannas
Authors: Kamara Alpha Y. , Menkir Abebe , Chikoye David , Tofa Abdullahi I. , Fagge Aminu A. , Dahiru Rabiu , Solomon Reuben , Ademulegun Temitope , Omoigui Lucky , Aliyu Kamaluddin T. , Kamai Nkeki
Published: August 2020

Striga hermonthica infestation causes significant losses of maize yield in the Nigerian savannas and several technologies have been developed and promoted to control Striga in maize. However, since no single technology has been found to be effective against Striga, integrated management is needed to achieve satisfactory and sustainable Striga control. Both on-station and on-farm trials were undertaken from 2013 to 2015 in Bauchi and Kano States of Nigeria to evaluate the performance of integrated Striga control technologies. In the on-station trials, a soybean–maize rotation did not suppress Striga in maize in either location. However, nitrogen application suppressed and reduced Striga infection, except in Bauchi in 2014. The soybean–maize rotation accompanied by N application reduced Striga damage in both locations. On farmers’ fields, rotating soybean with maize significantly reduced Striga infection. At the same time, the use of maize varieties with a combined tolerance to drought and resistance to Striga parasitism also increased maize grain yield on farmers’ fields, probably due to three factors: a reduction in Striga infection, reduced effects of a mid-season moisture deficit, and increased uptake of nutrients from the soil. We concluded that the use of Striga-resistant maize varieties in combination with the application of N fertilizer and rotation with soybean could increase the productivity of maize in Striga-infested fields in the Nigerian savannas.
Dynamic Compensation Under Uncertainty Shocks and Limited Commitment
Authors: Feng Felix Zhiyu
Published: August 2020

This article studies dynamic compensation and risk management under cash-flow volatility shocks. The optimal contract depends critically on firms’ ability to make good on promised future payments to managers. When volatility is low, firms with full commitment ability implement high pay–performance sensitivity to motivate effort from managers, and they impose large penalties on the arrival of volatility shocks to incentivize prudent risk management. In contrast, firms with limited commitment may allow excessive risk taking in exchange for low pay–performance sensitivity. When volatility becomes high, firms with full commitment defer compensation more, whereas firms with limited commitment must expedite payments.
The personal is the (academic) political: Why care about the love lives of theologians?
Authors: Muers Rachel
Published: August 2020

What might be learned, for theology, from recent interest in the complex love triangle of Nelly Barth, Charlotte von Kirschbaum and Karl Barth? I explore some aspects of how the story has been told, in and since Christiane Tietz's 2016 presentation and article, and argue that they expose deep-seated issues in and for the discipline of systematic theology. In particular, I draw attention to the focus on preserving the authority of the individual (male/masculine) author as the exemplar of theological practice; and to the reluctance to recognise the social, political and economic dimensions of sexuality and ‘domestic’ life. I argue that a properly ‘systematic theological’ approach to the Barth-von Kirschbaum story would involve critical and constructive theological reflection on theology's conditions of production: using historical contexts to help us recognise and respond to contemporary issues, without reducing such reflection to stories about individual authors.
Aflame but not consumed: Nestorius and the person of Christ
Authors: Sanders Kirsten Heacock
Published: August 2020

Though Nestorius is often thought to have erred largely due to his christological views, this article will suggest that it was his hamartiology that led to his errant christological claims.
ABŪ HĀŠIM AL-ǦUBBĀʾĪ, ALGÈBRE ET INFÉRENCE
Authors: Rashed Marwan
Published: August 2020

Cet article vise à restituer la doctrine du « signe du manifeste au caché » d'Abū Hāšim al-Ğubbāʾī (888-933). Il montre qu'Abū Hāšim a tendu à interpréter ce signe comme une inférence, dont il a reconnu deux types principaux : le type-1 (la « communauté de preuve », al-ištirāk fī al-dalāla) procède par déduction analytique de concepts en neutralisant les conditions de réalisation de ces derniers, c'est-à-dire leur soubassement ontologique. C'est, typiquement, la procédure la plus directement consonante avec l'ontologie modale d'Abū Hāšim. Le type-2 (la « communauté de cause », al-ištirāk fī al-ʿilla) exhibe un même rapport de causalité au plan du connu et au plan de l'inconnu et considère que la causalité au plan du connu est elle-même la cause de la causalité au plan de l'inconnu. Cette partition parfaitement inédite dans la philosophie et le kalām est en revanche préfigurée dans la doctrine de la preuve exposée par al-Ḫwārizmī dans son Algèbre. Al-Ḫwārizmī distingue en effet entre la preuve « par la cause » (bi-al-ʿilla), qui consiste à transférer une certaine déduction géométrique au plan de l'algèbre et la preuve « par l'expression » (bi-al-lafẓ) qui opère directement sur les expressions algébriques, qu'elle réduit analytiquement. En se fondant sur un texte d'Abū Hāšim consacré à la connaissance humaine qui paraît se référer à l’œuvre d'al-Ḫwārizmī, l'article suggère pour finir que le parallèle conceptuel étroit entre la doctrine de la preuve d'al-Ḫwārizmī et la doctrine du signe d'Abū Hāšim pourrait ne pas être une simple coïncidence. Deux appendices ont été ajoutés. Le premier traite de la lecture par al-Fārābī de la théorie de l'inférence d'Abū Hāšim. Le second, en s'appuyant sur toutes les données disponibles, établit pour la première fois les dates correctes et précises de la vie d'Abū Hāšim.
Echocardiographic study in children with osteogenesis imperfecta
Authors: Pinheiro Bruna S. , Barrios Patrícia M. , Souza Liliane T. , Félix Têmis M.
Published: August 2020

Background:

Osteogenesis imperfecta is a collagen type I bone disorder. Recently, extra-skeletal manifestations have been described, including many cardiovascular alterations. This study aims to report echocardiogram study in children with osteogenesis imperfecta compared to a control group.

Methods:

A cross-sectional comparative study took place in the Reference Center for Treatment of Osteogenesis Imperfecta in Southern Brazil. Fifty-four patients with osteogenesis imperfecta were paired with 54 controls, based on body surface area, and echocardiogram findings were compared.

Results:

All cases were asymptomatic for cardiac manifestations. The case group presented significant larger values in aortic diameter, left atrium diameter, left ventricule end-diastolic diameter, left ventricule end-systolic diameter, and right ventricle diameter compared with the control group. The analysis considering the severity of osteogenesis imperfecta shows that in mild osteogenesis imperfecta, the aortic diameter (p < 0.001), left atrium diameter (p = 0.002), left ventricule end-diastolic diameter (p = 0.001), left ventricule end-systolic diameter (p = 0.026), and right ventricle diameter (p < 0.001) were significantly larger than in the control group. Patients with moderate/severe osteogenesis imperfecta had similar results, with aortic diameter (p < 0.001), left atrium diameter (p < 0.001), left ventricule end-diastolic diameter (p = 0.013), and left ventricule end-systolic diameter (0.004) statistically larger than controls. Twenty-six (48.1%) of the cases had physiological tricuspid regurgitation and in controls this finding was observed in eight (14.8%) (p < 0.001).

Conclusion:

Children with osteogenesis imperfecta presented cardiac function within the normal pattern, but dimensions of left ventricular dimensions were increased compared to the ones of the controls.
Counter-Terrorism Medicine: Creating a Medical Initiative Mandated by Escalating Asymmetric Attacks
Authors: Court Michael , Edwards Brydie , Issa Fadi , Voskanyan Amalia , Ciottone Gregory
Published: August 2020

Introduction:

Since 2001, a burgeoning interest by health care professionals in the growing asymmetrical terrorist threat and its impact on health care preparation and response has seen significantly increased academic output around this nebulous subject. Despite this, there has failed to be a consolidation of this sub-specialty.

Discussion:

This editorial argues for the consolidation of the body of experience gathered since 2001 into an initiative called Counter-Terrorism Medicine (CTM). It proposes that previously discrete sub-specialty areas can be consolidated, with improvements in collective understanding, and can build on previous work to provide a non-political health care focused definition of terrorist events, based on the triad of Violence, Intent, and Heath Care Impact. It notes the importance this defining triad has in health care planning and response considerations. Finally, it defines the parameters of CTM within the larger specialty of Disaster Medicine (DM).

Conclusion:

There is a growing body of academic work on the health care implications of terrorism. The time is right to coalesce these into an initiative referred to as CTM and to consider this as a discrete part of DM.
Living alone, social networks in neighbourhoods, and daily fruit and vegetable consumption among middle-aged and older adults in the USA
Authors: Choi Yeon Jin , Ailshire Jennifer A , Crimmins Eileen M
Published: August 2020

Objective:

A social network is a valuable resource in later life. Therefore, the current study aims to investigate whether social networks within homes and neighbourhoods are associated with older adults’ daily fruit and vegetable consumption.

Design:

Cross-sectional secondary data analysis.

Setting:

USA.

Participants:

A nationally representative sample of 6865 community-dwelling older adults over age 53 in the Health and Retirement Study – Health Care and Nutrition Survey.

Results:

Older adults who lived alone with no children or friends nearby had the lowest fruit and vegetable consumption. However, the daily fruit and vegetable consumption of respondents who lived alone and had children or friends nearby or those who lived with someone and had no children or friends nearby was not statistically different from those who lived with someone and had children or friends nearby. This suggests that having a social network either at home or in the neighbourhood complements the absence of living with someone or having children or friends nearby and attenuates the negative association between limited social networks and daily fruit and vegetable consumption. A greater decrease in the number of fruits and vegetables consumed was observed among men when they lived alone with no children or friends nearby.

Conclusions:

Special attention should be given to older adults with limited social networks, especially older adults living alone with no children or friends nearby. Provision of help with grocery shopping and meal preparation as well as social support networks and more opportunities that can improve social engagement appear to be necessary.
Assessing factors influencing adolescents’ dietary behaviours in urban Ethiopia using participatory photography
Authors: Trübswasser Ursula , Baye Kaleab , Holdsworth Michelle , Loeffen Megan , Feskens Edith JM , Talsma Elise F
Published: August 2020

Objective:

To assess factors influencing dietary behaviours of adolescents in Addis Ababa, Ethiopia.

Design:

Using the qualitative participatory method Photovoice, participants received training on the basics of Photovoice and took photographs related to (un)healthy eating in their environment. Transcripts of individual interviews, focus group discussions and photographs were coded for thematic analysis.

Setting:

One private and one public school located in the same, central neighbourhood in Addis Ababa, Ethiopia to explore how school populations of different socio-economic status experience the same neighbourhood environment.

Participants:

Twenty-six adolescents aged 14–19 years old, of which there were seventeen girls and nine boys.

Results:

Findings from the current study indicate that food safety concerns appear to be the major influencing factors for adolescents’ dietary choices. Unhealthy and unsafe foods appear to be widely available and/or affordable in adolescents’ neighbourhoods and almost half of the photographs taken by adolescents depicted poor hygiene conditions related to food vendors. Participants considered foods available in their environments as generally unsafe, calling for more packaged food.

Conclusions:

Concerns for food safety, hygiene and affordability are the dominating factors for adolescents’ food choices. These concerns, together with limited nutrition knowledge and preference for packaged foods, could make cheap, ultra-processed packaged foods more desirable.