bluuebunny/crossref_metadata_2025 huggingface dataset:
PELATIHAN E-COMMERCE GUNA PENGEMBANGAN PRODUK KULINER LOKAL PADA KOMUNITAS UKM TIKIT QURRATA A’YUN KOTA CIMAHI
Authors: Murwenie Ira , Kartiko Erik , Avrianto Alam , Gumilar Irfan Rizki , Kurnaeli Kurnaeli
Published: November 2024

Berdasarkan hasil tinjauan lapangan diketahui bahwa salah satu penyebab rendahnya tingkat pengembangan produk UKM di Kota Cimahi adalah karena kurangnya pemahaman para pelaku usaha terhadap penggunaan media digital sebagai sarana promosi dan pengembangan produk. Jika dikaitkan dengan program pengembangan pariwisata dan ekonomi kreatif yang dicanangkan oleh Kementerian Pariwisata dan Ekonomi Kreatif, maka kegiatan usaha kuliner lokal yang dilakukan oleh Komunitas UKM TIKIT Qurrata A’yun, Kecamatan Padasuka – Kota Cimahi, sebagian besar masih dilakukan secara sederhana (word to mouth) dan belum dikemas dengan merek produk memadai sehingga layak untuk dipasarkan secara online. Berdasarkan kondisi ini maka pelaksanaan kegiatan PKM dalam memberikan pelatihan e-commerce pada Komunitas UKM TIKIT Qurrata A’yun dianggap sangat penting dalam tujuannya untuk dapat dipasarkan secara luas dan mendorong pengembangan  produk-produk kuliner lokal hasil produksi para anggota komunitas. Hasil pelatihan ini, secara singkat dapat dikatakan berhasil memberikan dampak yang signifikan terlihat dari peningkatan pemahaman peserta pelatihan yang naik 50% dari yang awalnya tidak paham tentang e-commerce menjadi lebih paham.
DIFERENÇAS MORFOLÓGICAS EM BOANA PRASINA E BOANA ALBOPUNCTATA: ESTUDO COMPARATIVO EM DUAS ESPÉCIES DISTINTAS
Authors:   , Neves Jennifer Coleta
Published: November 2024

A família Hylidae é reconhecida por sua ampla diversidade em termos de
modos de vida, reprodução, alimentação e habitat. Este estudo se concentra em duas
espécies específicas, Boana albopunctata e Boana prasina, que compartilham
semelhanças na distribuição geográfica e no comportamento adaptativo em relação
aos habitats.
Apesar das similaridades, a literatura científica apresenta uma carência de
estudos sobre as espécies no geral, sobre seus modos de vida e principalmente uma
comparação entre elas. Portanto, este projeto tem como objetivo preencher essa
lacuna ao investigar e identificar as diferenças morfológicas entre as mesmas,
contribuindo para uma compreensão mais aprofundada de ambas.
A pesquisa foi conduzida na Serra dos Cocais, localizada em Valinhos, São
Paulo, explorando dois sítios reprodutivos. Por meio de busca ativa através de
observação visual e auditiva para retirada de fotografias dos espécimes durante o
período noturno, ao longo de cinco dias em cada local, totalizando 10 dias de
amostragem. Após as fotografias dos espécimes, os indivíduos foram prontamente
liberados para minimizar o estresse possivelmente causado.
Ferramentas de geoprocessamento, como o QGIS e Google Earth, foram
empregados para o levantamento geográfico da área de estudo. A análise morfológica
incluiu técnicas estatísticas multivariadas, considerando variáveis como o tamanho
corporal (CRC) e características fenotípicas. Esses dados foram compilados para
identificar e discutir as distinções morfológicas entre as espécies, contribuindo para
pesquisas posteriores relacionadas à identificação.
Este trabalho tem como objetivo consequente preencher lacunas no conhecimento
dessas espécies de Hylidae, fornecendo esclarecimentos valiosos sobre a diversidade
desses anfíbios na região da Serra dos Cocais.
Potencializando a alfabetização e o pensamento analítico e leitor nas crianças
Authors: Carvalho Leila Pereira de , Araújo Marcia Moreira
Published: November 2024

A publicação é uma realização junto a professores do Ensino Fundamental anos iniciais participantes da pesquisa, com ações e orientações pedagógicas com foco na alfabetização como metodologia em sala de aula como forma de potencializar as habilidades analíticas e leitoras nas crianças por intermédio da alfabetização.
O Guia é composto de uma série de materiais voltado ao Ciclo de Alfabetização (1º, 2º e 3º anos) dos Anos Iniciais do Ensino Fundamental. O material está direcionado ao Professor, com orientações para o planejamento e propostas de sistematização da aprendizagem, com atividades voltadas à prática.
HANSENÍASE
Authors: Carvalho Carlos Alberto de , Ribeiro Gilberto de Sousa , Braga Renan Barros , Souza Jussara Aparecida de , Araújo Kário Francisco Rodrigues de , Vinhal Sandra Maria , Gomes Janeide de Almeida , Santos Claudenira da Silva , Batista Elisa de Moraes , Memoria Larissa Vanessa Ferreira , Memoria Sammia Valeska Ferreira , Silva Alessandra Pinheiro da , Fenelon Antonio Tiago da Costa , Melo Emilly Araujo de , Cruz Thays Luana da , Rossi Degmar Aparecida Netto , Domingues Erika Sousa , Dantas Bianca Farias , Nóbrega Hayanne Oliveira da Silva , Maciel Juliana Maria dos Santos Silva
Published: November 2024

O Brasil carrega a classificação de segundo colocado no mundo em número absoluto de casos novos registrados de hanseníase, ficando atrás da Índia, e liderando os países endêmicos das Américas quanto à prevalência e detecção de casos novos. A doença pode afetar todas as faixas etárias e é classificada como indeterminada, tuberculóide, virchowiana, dimorfa ou neural pura, havendo variações entre as lesões dermatológicas e neurológicas em cada uma dessas formas, podendo ocasionar incapacidades físicas de grau 0, 1 e 2.
Frente a isso, esta obra foi desenvolvida a fim de analisar o perfil epidemiológico de acordo com sexo e idade associando às manifestações clínicas apresentadas pelos pacientes diagnosticados com hanseníase no município de Marabá/PA no período de 2014 a 2017, com todos os casos de hanseníase registrados e notificados no período de 2014 a 2017 disponíveis no SINAN. Já, para construção da obra, foi realizado um estudo epidemiológico e de abordagem quantitativa, retrospectivo, observacional, analítico e transversal.
Nos dados analisados foram identificados nos anos de 2014 a 2017 no município de Marabá/PA, a ocorrência de 423 casos diagnosticados com hanseníase; percebe-se um elevado número de casos de hanseníase notificados no período da pesquisa (2014– 2017) nesse município. Por fim, esta obra contribui para que a vigilância em saúde do município de Marabá por meio das equipes das unidades de saúde, tenham conhecimento da situação epidemiológica para planejar estratégias de combate à hanseníase.
AS DOBRADURAS MÁGICAS
Authors: Henkel Milena Da Silveira , Bona Aline Silva De , Santos Théo Petró dos , Germano Rafaela de Andrades , Drey Rafaela Fetzner
Published: November 2024

Embarque nesta aventura lotada de originalidade e personalidade! Aprenda a tornar seus dias mais alegres com as mais variadas ideias matemáticas que podem salvar os seus dias cinzas de chuva enchendo os mesmos com cores cintilantes!
Em "As dobraduras mágicas" você acompanhará a vida de Zul, uma jovem garota apaixonada pelas maravilhas que o mundo pode oferecer, e que com ajuda de seu avô sempre desenvolve maneiras brilhantes de superar toda e qualquer adversidade. Não se sinta acanhado de aprender juntamente com as histórias envolventes, afinal, a matemática é nossa amiga. Você descobrirá que a partir dela podemos criar tantas obras fenomenais que tenho certeza que em você também despertará esse ímpeto matemático. Além do mais, com uma arte linda como essa, fica difícil não se maravilhar com cada aventura.
Desfrute dessa bela obra que viaja entre os reinos da arte e da geometria, pois, se você ainda não conhece nossa querida autora, prepare-se para virar um fã de carteirinha, ficar com gostinho de quero mais, morrendo de vontade de ler a próxima aventura e acender a chama que te fará buscar novas obras que pairam sobre o mesmo limiar.
Transformação Digital na Administração Pública: Estrutura Conceitual para uma Governança Eficiente e Inclusiva
Authors: MADEIRA JULIANO SILVA
Published: November 2024

A Transformação Digital (TD) na administração pública é um movimento
fundamental que exige uma reformulação abrangente e integrada das
operações e estruturas governamentais, permitindo que os serviços e as
interações com os cidadãos sejam mais acessíveis, eficientes e econômicos.
Este processo envolve a introdução de tecnologias digitais, além de uma
revisão detalhada das políticas, dos processos e da organização estrutural para
que as administrações públicas possam responder de forma mais eficaz às
demandas de uma sociedade em constante evolução.
O conceito de Transformação Digital, embora originado na década de
1990 sob diferentes denominações, evoluiu para incorporar não apenas a
digitalização de serviços governamentais, mas uma verdadeira reformulação do
papel do governo. Inicialmente, o termo e-gov representava o uso de
Tecnologias da Informação e Comunicação (TICs) para disponibilizar
informações e serviços governamentais. Com o tempo, o foco ampliou-se para
o Governo Digital, que busca oferecer uma experiência integrada e simplificada
aos cidadãos, incorporando tecnologias emergentes, como big data,
inteligência artificial e blockchain. No entanto, a Transformação Digital no setor
público vai além do simples uso de tecnologias avançadas. Envolve mudanças
estruturais e culturais dentro das organizações, demandando uma adaptação
completa dos métodos de trabalho e das interações com o público
Document: Thirty Years after the Oslo Peace Accords: Interviews with Joel Singer
Authors: Cohen-Almagor Raphael
Published: November 2024

ABSTRACT: This article contains edited excerpts of my interviews with Joel Singer about his participation in the 1993 Oslo peace talks. Section I relates to Singer's relationships with the three other Israeli negotiators, Yair Hirschfeld, Ron Pundak and Uri Savir. Section II concerns the Palestinian delegation, its key players and those they represented. Section III discusses the Israeli-Palestinian negotiations and the drafting of the document. Singer describes a constructive division of labor between himself and Savir and the convivial atmosphere in the room where the two delegations would also relax together, joke and laugh. The last two sections, IV and V, relate to the Oslo Accords and their implementation.
Designing a secure and high-performing e-commerce platform for public cloud
Authors: Oreoluwa Omoike
Published: November 2024

This study explores the design and implementation of a secure and high-performing e-commerce platform using public cloud infrastructure. The rising popularity of e-commerce has emphasized the need for scalable, cost-efficient, and secure platforms that can meet the dynamic needs of users. Cloud computing provides the necessary resources for building such platforms, but security and performance remain critical concerns. This paper examines strategies for securing an e-commerce platform hosted on a public cloud while optimizing for performance. Data collection, instrumentations, and analysis were employed to identify key factors influencing the security and performance of the platform. The results however shows a multi-layered security architecture, along with an elastic cloud infrastructure, can significantly enhance platform performance. Recommendations are provided for future research and practical implementation.
Economic influences of agriculture production and import mechanisms through commodity market in the nepalese context
Authors: Lila Nath Dhungel  , kushendra Bahadur Mahat  , Ananyaa Pandey
Published: November 2024

Agriculture production not only manage food and domestic needs rather enhance nation’s economy. Nepalese production is relying from neighbours through import due to insufficiency. This study design to analyse the impact of agricultural cereal production and import scenario in the Nepalese context. A mixed method approach, both Qualitative and Quantitative data utilized for this Doctoral study-based paper, Farmers of all Seven Provinces samples with HHs interview and secondary data of agriculture and Custom data used. The study was conducted from January to June 2023. The findings revealed the major cereal crop production from own like paddy, maize, wheat and millet are limited for some season. In addition, import from India shifting large economy to India through import. The agriculture production meeting domestic needs like seasonal food and market stock. Whereas seeds, input and mechanization dependency largely depending on neighbours due to no manufacturing of own. The study concluded as agriculture production is a major source of income and food for Nepal. Limited month of sufficiency at the local production bounded Nepal depends on import. The cause was found as lack of sufficient input system, low priority of agriculture from all sectors, diversity and low-political priority. Food Diversity and local production enhancement is the ultimately way out to deal with this issue.
Effective plant protein extraction to enhance plant protein functionality and impact of plant protein over animal protein on health
Authors: Munalisa Poppy
Published: November 2024

Plant proteins extracted with traditional method are generally of lower quality, with a less favorable amino acid profile as compared to animal protein. This review explores effective protein extraction methods to enhance plant protein functionality. Moreover, animal protein is associated with high risk of cardiovascular disease and other disease. This review will highlight the impact of plant protein over animal protein on cardiovascular disease and other health Issues.
Impact of investment climate on foreign direct investment in Nigeria, Ghana, Kenya and South Africa,
Authors: Irene Nkechi Onwuka
Published: November 2024

The study examined the Impact of Investment Climate on Foreign Direct Investment in Nigeria, Ghana, Kenya and South Africa, for the period of 2000 to 2021. The focus of this study is on how the business environment in Nigeria, Ghana, Kenya and South Africa influences foreign direct investment. Specific goals are as follows: (i). Evaluate critically the effect of the economic investment climate in Nigeria, Ghana, Kenya and South Africa on the inflow of FDI The variable scope include economic investment climate (ease of doing business index, gross domestic product, inflation rate), political investment climate (political stability index, corruption perception index, quality of institutions), environmental investment climate (nitrous-oxide emission, population density, land/air pollution rate) as the independent variable. The dependent variable was foreign direct investment inflows. Time series analysis, and more specifically the multiple panel regression analysis method, was used in analyzing the data adopting the Cobb Douglass model for its theoretical framework and data was sourced from the Statistical Bulletin of the countries studied and the World Bank Statistics.\The results show that, Economic investment climate variable (GDP) had significant positive effect on the inflow of foreign direct investment into Nigeria, Ghana, Kenya and South Africa. While inflation have positive insignificant relationship with FDI; It was recommended that; Efforts should be made by the governments of Nigeria, Ghana, Kenya and South Africa to enhance their economic fortunes by strengthening their economy through engaging in massive production for exports which will boost economic growth and as well attract more foreign direct investment
Review on herbal drug used in various dental problems
Authors: AD Burande  , AS Zadokar  , AM Deshmukh  , AB Avachar  , AR Nikam  , SA Shinde  , RH Kale  , KR Biyani
Published: November 2024

Polyherbal tooth paste is gaining recognition as an organic a substitute for conventional oral care utilizing the advantages of various herb constituents for elevated oral hygiene this review looks at the contents evaluation and antibacterial properties of polyherbal toothpaste with a focus on key components of medicinal value such clove tulsi neem and aloe vera we discuss formulation techniques and their effects on stability and effectiveness as well as assessment instruments to measure physical and microbiological characteristics in vitro tests show that polyherbal toothpaste is effective against a common oral infections in comparison to typical products clinical assessments offer further context for user experiences and safety profiles all things considered polyherbal toothpaste satisfies consumers growing need for natural goods while offering an economical solution to dental hygiene
Pix2Pix GAN for Realistic Lung CT scans Generation from COVID-19 Lesion Masks
Authors: Vikraant Gopal Sharma  , Vedant Mehul Oza  , Prathamesh Rajesh Panchal  , Meet Ashok Nadoda
Published: November 2024

GANs have recently become one of the most promising directions of machine learning for generative tasks in deep learning. By using architectures such as CNN, GANs can learn relationships in input data without any human intervention and generate new examples that are similar to the original data set. This paper aims at understanding what GANs are and how they work, and the different types of GAN models with a special focus on their application in image synthesis, style transfer, and text-to-image synthesis. The GAN framework consists of two neural networks: The two primary components of the model are the Generator and the Discriminator. The generator’s goal is to generate ‘realistic’ data such that the discriminator cannot differentiate between the two, while the discriminator’s goal is to distinguish between the real and the fake data. Some other GAN variants include Vanilla GAN, conditional GAN (CGAN), Deep Convolutional GAN (DCGAN), Laplacian Pyramid GAN (LAPGAN) and Super Resolution GAN (SRGAN), all of which have made significant improvements in producing convincing images. The structures of the generator model, which produces data from noise, and the discriminator model, which checks the validity of the data produced, are also considered. The study focuses on the concept of loss functions including the generator loss, discriminator loss and minimax loss in the training of GANs. Pre- processing the data for GAN training is a very crucial step that requires careful consideration as well as data cleaning. This is because when using content and adversarial loss functions simultaneously, it is easier to find the right balance between the photorealism of the images and their structural similarity to the source material. By training carefully and iterating over the process, GANs exhibit high performance in sample generation, thereby leading to the new state of generative modeling. It will be beneficial for any researcher or practitioner by providing an understanding of artificial intelligence and generative modeling
Need and struggles of homeless people: A study based on Nepalese context
Authors: Shivaraj Parajuli  , Nagender Kumar
Published: November 2024

Homeless are these people who are unable to manage their basic needs and live under the sympathy of others. Nepal experienced an increasing trend of homeless people. This study highlights the daily challenges and necessities of homeless people in Nepal. A cross-sectional study with a Qual-Quan method applied in the Nepalese context, the data were collected Province-wise during 2023. The study further shows that the basic requirements like regular food are somehow managed from the helping hand but the cloths and shelters are very challenging to manage nowadays. The challenges are the different types of homeless age groups peoples and genders in a same care center. The health issue is a critical to manage of homeless center due to the lack of facilities and services. Government and development priorities are minimal for the homeless and nowadays homeless issue are increasing. The settlement arrangement with basic privileges is very difficult to manage through the local administration and homeless-center as lack of resources and paper documentation are too hectic and prolonged. The study further concluded as the homeless needs are hardly meet and additional supports from the multi-sectoral are in demand but the government priorities are less. However, the local community supports from the self-levels benefiting homeless centers but this is not enough to manage for long time and special care and services are essential and skill-based program and additional budget from the Government sectors to the poorer is the future requirement.
Globalization and changing gender norms: A comparative study of working women in Japan, Singapore, and India
Authors: Myeongjae Lee
Published: November 2024

Globalization's impacts on gender roles in Asia remain inadequately understood despite extensive scholarship on women's empowerment worldwide. This comparative study investigates how increasing integration into the global economy shapes gender norms and labor force gender gaps in Japan, Singapore and India. Quantitative analysis of World Bank indicators over 1990-2020 reveals divergent patterns; while female labor participation rates converge towards egalitarian norms in Japan and Singapore (rising from 48.89% to 49.29%, and 51.34% to 60.01% respectively), India exhibits persistence of gaping gender imbalances, only narrowing from 32.7% to 32.9% over thirty years. These macro-level trends provide impetus for follow-up qualitative phenomenological study through 1) ethnographic observations of professional women in Tokyo, Delhi and Singapore and 2) in-depth, semi-structured interviews with 60 total working women (n=20 per site) across corporate, service and informal sectors. Thematic analysis of narratives will elucidate common and distinctive mechanisms by which global and local forces interact to moderate traditional patriarchal attitudes and yield varied empowerment outcomes for Asian women. Blending macro-statistical and ground-level qualitative approaches enables holistic understanding of globalization's socioeconomic influences on renegotiating gender relations in context. Findings will inform theory and practice on global forces, development and women's welfare in late modernity.
Analysis of related factors related to the quality of life of post-stroke patients at Royal Prima Hospital Medan
Authors: Yang Tianxue  , Liena  , Fioni
Published: November 2024

Stroke is a severe global health problem and is ranked the third leading cause of death after heart disease and cancer. According to WHO data, about 15 million people have a stroke each year, with more than 5 million suffering from permanent disability. In Indonesia, the prevalence of stroke increases with the increase in risk factors such as hypertension and unhealthy lifestyles. This study aims to analyze the factors that affect the quality of life of post-stroke patients at Royal Prima Hospital Medan. The method used is non-experimental quantitative research with a descriptive approach and associative analysis. The study was conducted at the Royal Prima Hospital Medan, a population of patients undergoing post-stroke rehabilitation in the last three months. A sample of 60 patients was taken using the Slovin formula, and data analysis was carried out univariate, bivariate using the Chi-Square test, and multivariate with logistic regression analysis. The results of the study showed a significant relationship between age factors (p-value = 0.002), gender (p-value = 0.001), psychological condition (p-value = 0.002), physical condition (p-value = 0.004), and family support (p-value = 0.000) on the quality of life of patients. Family support was the most significant factor, with an odds ratio (OR) of 11,686, indicating that patients who received family support were likelier to achieve a good quality of life. These findings are expected to provide insights into designing more effective rehabilitation programs and raise awareness about the importance of support for post-stroke patients.
The impact of agricultural development on socioeconomic well-being: A sociological review of African case studies and implications for U. S. policies
Authors: Adebimpe Oluwabukade Adefila  , Oluwatosin Omotola Ajayi  , Adekunle Stephen Toromade  , Ngodoo Joy Sam-Bulya
Published: November 2024

This sociological review examines the impact of agricultural development on socioeconomic well-being in African communities, drawing on case studies that highlight the role of social factors—class, ethnicity, and community networks—in shaping development outcomes. African agricultural initiatives have revealed complex interactions between economic and social dimensions, demonstrating that agricultural growth alone does not automatically translate to equitable socioeconomic benefits. The influence of class disparities often means that wealthier groups gain disproportionately from development projects, while marginalized ethnicities and lower-income communities encounter barriers to economic participation. Community networks, however, play a critical role in mitigating such inequalities by promoting resource sharing, knowledge exchange, and resilience-building within rural societies. This analysis offers valuable insights for U.S. policy aimed at rural poverty reduction and inclusive growth. Specifically, it suggests that U.S. agricultural policies could benefit from integrating sociological perspectives that address social disparities and strengthen community bonds within rural areas. By recognizing the role of social capital and community networks, U.S. policies could enhance resource accessibility and foster inclusive economic growth, particularly in underserved rural regions. The review concludes by identifying directions for future research, emphasizing the need to explore how agricultural development influences social mobility within rural communities, particularly regarding class and ethnic dynamics. Additional areas for investigation include the intersection of economic development and social inequality, as well as the sociological impacts of agricultural policies on rural household dynamics. Understanding these relationships can inform policies that not only support agricultural productivity but also ensure that growth leads to improved well-being across all social groups.
Pharmacotherapy of Rasmussen’s Encephalitis: A Comparison of Epilepsia Partialis Continua with Rituximab and Azathioprine
Authors: Sultan Akbar
Published: November 2024

Rasmussen’s Encephalitis is a rare neurological condition causing inflammation of the brain, which thereafter can result in seizures, neuronal death, and significant neurological deficits. Its exact cause is unknown and it typically presents in children. The best known treatment is a surgical hemispherectomy to prevent the spread of inflammation, however this is invasive and not without risk. The best therapeutic approach has been with immunomodulation using the antimetabolite agent, azathioprine. Monoclonal antibodies such as rituximab have shown promise in early clinical trials for the treatment of Rasmussen’s Encephalitis, but little has been done to compare the efficacy of rituximab versus azathioprine. A systematic review was then conducted with a study in which patients were treated with rituximab for Rasmussen’s Encephalitis (RE) compared to a study in which patients were treated with azathioprine. The presence of focal encephalitis characterized by epilepsia partialis continua (EPC) was measured in both studies following the treatments. Azathioprine and Rituximab both had statistically significant effects on decreasing the incidence of epilepsia partialis continua when compared to their respective controls. However, rituximab seemed to have a greater effect on reducing the incidence of EPC than azathioprine. Rituximab seems to have an immense potential in reducing EPC in patients with RE. For this review, Rituximab seemed to have a greater reduction in EPC than azathioprine. Further studies with greater sample sizes assessing reductions in the several other complications of RE must be conducted in order to confirm whether or not Rituximab is truly a better choice than Azathioprine.
The role of regulatory agencies in public health emergencies: A critical review of global approaches and challenges
Authors: Juliet Obioma Adione
Published: November 2024

Regulatory agencies play a pivotal role in public health emergencies by ensuring that medical products, including vaccines, diagnostics, and therapeutics, are rapidly available while maintaining safety and efficacy standards. The COVID-19 pandemic, along with past crises such as the Ebola and Zika outbreaks, exposed both strengths and vulnerabilities in global regulatory frameworks. This paper critically reviews the role of regulatory agencies in public health emergencies, synthesizing existing literature to present new insights into their operational challenges and the reliance strategies employed to bridge capacity gaps. By examining case studies, such as the reliance on the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) by low- and middle-income countries (LMICs), this paper highlights the importance of global cooperation and reliance mechanisms in managing crises. Furthermore, it addresses challenges such as resource constraints, disparities in regulatory capacity, and ethical dilemmas faced when approving products based on limited data. The paper also explores the future direction of regulatory science, emphasizing the need for greater global regulatory convergence, capacity building, and the adoption of innovative digital tools. Ultimately, the paper argues that while reliance strategies are vital, long-term investment in national regulatory systems and global harmonization efforts are essential for a more equitable and effective response to future public health emergencies.
Leveraging regulatory pharmacist expertise to develop a framework for drug repurposing in underserved areas of the USA
Authors: Juliet Obioma Adione
Published: November 2024

The United States continues to grapple with healthcare access disparities, particularly in underserved regions. Regulatory pharmacists, with their unique expertise in pharmaceutical laws, drug development, and safety regulations, can play a vital role in drug repurposing efforts. This paper proposes a framework for utilising regulatory pharmacist expertise to develop drug repurposing strategies to meet unmet medical needs in underserved areas. We explore the regulatory hurdles, the necessity for collaborative efforts between healthcare professionals, and the potential for drug repurposing to improve healthcare outcomes in rural and socioeconomically disadvantaged communities.
The role of Artificial Intelligence in enhancing cybersecurity: A comprehensive review of threat detection, response, and prevention techniques
Authors: Chigozie Kingsley Ejeofobiri  , Adedoyin Adetumininu Fadare  , Olalekan Olorunfemi Fagbo  , Valerie Ojinika Ejiofor  , Adetutu Temitope Fabusoro
Published: November 2024

As cyber threats continue to grow in scale and sophistication, traditional cybersecurity solutions have become increasingly insufficient to mitigate evolving risks. Artificial Intelligence (AI) has emerged as a powerful tool for enhancing cybersecurity by improving threat detection, automating response mechanisms, and preventing attacks before they occur. This review explores the intersection of AI and cybersecurity, focusing on AI-driven techniques in threat detection, automated response systems, and preventive measures. Furthermore, the paper discusses the challenges of deploying AI in cybersecurity, including adversarial attacks and ethical considerations, and provides future directions for research.
Analisis Vegetasi Gulma Rerumputan Pada Areal Pertanaman Cengkeh (Syzygium aromaticum) Di Negeri Hatu Kabupaten Maluku Tengah
Authors: Goo Nureny , Tanasale Vilma Laurien
Published: November 2024

Gulma merupakan tumbuhan yang kehadirannya tidak diinginkan karena dapat menurunkan hasil produksi. Komposisi dan keanekaragaman gulma ikut menentukan struktur areal pertanaman yang pada akhirnya akan berpengaruh pada fungsi ekologis. Kehadiran gulma dapat dijumpai pada semua areal pertanaman. Penelitian ini dilaksanakan di Negeri Hatu Kabupaten Maluku Tengah pada Bulan September 2022. Penelitian ini bertujuan untuk menginventarisasi jenis gulma rerumputan pada areal pertanaman cengkeh.. Proses pengumpulan data dilapangan dilakukan dengan menggunakan metode kuadrat dengan petak sampel berukuran 1 m x 1 m dan diletakan dibawah tegakan  tanaman cengkeh. Hasil penelitian menunjukan ditemukan 8 jenis gulma rerumputan pada areal pertanaman cengkeh. Berdasarkan nilai SDR terdapat 3 jenis gulma rerumputan dominan yaitu Eleusine indica L, Imperata Cylindrica,  dan Cynodan dactylon.
Uji Kompatibilitas Umur Dan Jenis Root Stok Dengan Metode Grafting Juvenil Pala Terhadap Keberhasilan Grafting
Authors: Lesilolo Marthini , Rehatta Herman , Kermite Fiolita
Published: November 2024

Perbanyakan tanaman secara vegetatif adalah perbanyakan tanaman dengan menggunakan organ-organ tanaman yang dapat menghasilkan tanaman baru yang sama dengan induknya  Grafting merupakan salah satu teknik perbanyakan vegetatif menyambungkan dua bagian tanaman batang bawah dan batang atas dari tanaman yang berbeda sedemikian rupa sehingga tercapai persenyawaan. Penelitian bertujuan untuk menentukan pengaruh umur root stok, jenis root stok dan interaksi antara umur dan jenis root stok terhadap kompatibilitas grafting juvenil pala yang meliputi parameter: kompatibilitas root stok dan entris, jumlah tunas dan jumlah daun. Penelitian ini dilaksanakan dilokasi Laboratorium Grafting Tanaman di Desa Layeni Kec.TNS, Kabupaten Maluku Tengah Provinsi Maluku dari September- November 2020. Peneliti menggunakan bibit pala berumur 1, 2, dan 3 bulan dengan jenis Myristica     fragrans Houtt, Myristica argentea Warb, dan Myristica fatua. Penelitian menggunakan Rancangan Acak Lengkap dengan tiga ulangan. Hasil penelitian menunjukkan bahwa interaksi umur root stok dan  jenis root stok memberikan pengaruh nyata terhadap peubah yang diamati dan interaksi terbaik untuk uji kompabilitas adalah umur root stok 1 bulan dengan jenis pala Myristica fatua (66,7 %), sedangkan untuk jumlah tunas dan jumlah daun umur root stok 3 bulan dan jenis pala  Myristica fatua memberikan hasil terbaik  (7,33  dan 14 helai daun).
Respons Benih Kopi Tuni (Coffea canephora) pada Fase Pembibitan pada Kondisi Defisit Air Kapasitas Lapang
Authors: Marzuki Ilyas , Polnaya Fransin , . Fajrin
Published: November 2024

Penelitian ini mengkaji respons perkecambahan dan pertumbuhan bibit kopi Tuni (Coffea canephora sp.) pada kondisi defisit air kapasitas lapang (KL). Dua faktor/perlakuan yang diuji, persentase defisit air KL dan interval pemberian air rehidrasi. Defisit air diberikan empat taraf:  100% KL, 75% KL, 50% KL, dan 25% KL, sementara pemberian air rehidrasi diberikan tiga taraf : interval 5, 7, dan 9 hari. Kombinasi perlakuan  ditata menggunakan Rancangan Acak Kelompok dengan empat ulangan. Hasil penelitian menunjukkan bahwa defisit air KL pada fase perkecambahan berpengaruh signifikan terhadap Daya berkecambah benih dan panjang akar, tetapi tidak signifikan terhadap panjang hipokotil. Pada fase bibit, defisir air KL dan frekuensi rehidrasi termasuk interaksinya tidak berpengaruh terhadap pertambahan tinggi bibit, luas daun, dan laju pertambahan tinggi bibit. Namun demikian, laju pertambahan luas daun secara signifikan dipengaruhi oleh interaksi antara Defisit air KL dan Frekuensi rehidrasi. Disimpulkan bahwa defisit air hingga 100% KL selama periode perkecambahan (selama dua bulan) justeru memperbaiki daya berkecambah benih kopi Tuni, namun tidak pada fase bibit.
Optimasi Media Ela Sagu Dan Dedak Untuk Pertumbuhan Dan Produksi Jamur Volvariella sp.
Authors: Alkatiri Nofel , Taribuka Johana , Kalay A. Marthin
Published: November 2024

Jamur Volvariella sp. berpotensi sebagai salah satu sumber pangan yang belum dibudidayakan oleh masyarakat. Jamur ini memiliki habitat khusus yaitu pada limbah olehan pati sagu yang dikenal dengan sebutan ela sagu. Tujuan  penelitian ini untuk mendapatkan konsentrasi dedak yang dapat ditambahkan pada ela sagu dan pada luasan permukaan media yang baik untuk pertumbuhan dan produksi jamur Volvariella sp. Penelitian merupakan percobaan dua faktor yaitu konsentrasi dedak dalam ela sagu yaitu 0%, 10%, 20%, dan 30%, dan luasan permukaan media tumbuh yakni 875 cm2 , 625 cm2, dan 375 cm2.  Penelitian dirancang menggunakan Rancangan Acak Lengkap (RAL) dengan tiga ulangan. Hasil penelitian ditemukan bahwa penggunaan ela sagu yang ditambahkan dengan dedak dan ditempatkan pada wadah dengan ukuran luas permukaan berbeda berpengaruh terhadap jumlah tubuh buah tumbuh, jumlah tubuh buah panen, dan bobot segar tubuh buah konsumsi, dan tidak berpengaruh terhadap diameter tubuh buah konsumsi, tinggi tubuh buah konsumsi, bobot rata-rata tubuh buah konsumsi. Ela sagu dengaan persentase dedak 10 % dan ditempatkan pada wadah dengan luas permukaan 875 cm2 lebih baik untuk meningkatkan  jumlah tubuh buah tumbuh dan tubuh buah panen jamur Volvariella sp.
The Adaptation of Ciherang Rice Variety Roots to Various Levels of Low Nutrient Stress in Tidal Swamp Soils
Authors: Kesmayanti Novisrayani , Purwanto Ruli Joko , Mareza Evriani , Kalsum Ummi , Zaman Ilham Nur
Published: November 2024

Rice cultivation in tidal land has many abiotic stresses. One of them is low nutrient stress. This research aims to determine and study the adaptation of rice roots to various levels of low nutrient stress in tidal swamp soil. These research was carried out from September 2016 to May 2017 at the Experimental Garden, Laboratory of Botany and Plant Physiology of Faculty of Agriculture of IBA University in Palembang, South Sumatra Province. These experiment used a Randomized Block Design with three replications and four low nutrient levels. The treatments are: N1 = 40% Fertilization dose (FD, N2 = 50% FD, N3 = 60% FD and N4 = 100% FD. The 100% FD is 300 kg urea. ha-1, 100 kg SP-36.ha-1 and 150 kg KCl.ha-1. These research used Ciherang rice varieties that planted in pots containing 12 kg of tidal swamp soil type B from Bunga Karang Village, Tanjung Lago District, Banyuasin Regency, South Sumatra Province, Indonesia. The results showed that low nutrient stress increased root length, root weight, root length density, root weight density, root weight ratio and number of tillers, but reduced crown weight and panicle weight per clump
Treatment for acute alcoholic-alimentary pancreatitis with peritoneal syndrome
Authors: Samgina T. A. , Kochetova L. V.
Published: November 2024

A large number of publications on surgical treatment of acute alcohol-induced pancreatitis (AAP) with peritonitis indicates the importance of the problem and the need for a differentiated approach to treatment. The aim of this study is to determine the optimal treatment policy for acute alcohol-associated pancreatitis with peritonitis. The study included 114 male patients diagnosed with acute alcoholic pancreatitis and peritoneal sepsis, with an average age of 48.6 ± 6.4 years. They were admitted to the surgical departments of clinical hospitals between 2013 and 2023. The diagnosis of AAP was confi med based on clinical, laboratory, and instrumental findings. The classification of acute pancreatitis recommended by the National Clinical Guidelines of the Ministry of Health of the Russian Federation (2015 and 2020) has been applied. The Acute Physiology and Chronic Health Evaluation II (APACHE II) scale has been used to assess the severity and prognosis of the disease, while the Sequential Organ Failure Assessment (SOFA) scale has been used to evaluate organ failure. Based on the results, an algorithm for the treatment of acute alcoholic and alimentary pancreatitis with peritoneal syndrome has been proposed, taking into account the type of pancreatic necrosis, the extent of pancreatic damage, and the nature of fl uid accumulation. For patients with edematous pancreatitis, small-focal sterile pancreatic necrosis, and enzymatic peritonitis, percutaneous ultrasound-guided abdominal and omental drainage is recommended. In severe and moderate acute alcoholic-alimentary pancreatitis, with enzymatic peritonitis (more than 8 points on the APACHE II scale), which is manifested during diagnostic and sanitation laparoscopy by the presence of a hemorrhagic effusion and a large number of plaques of steatonecrosis on the parietal peritoneum and the large omentum, we should use an endovisual method of draining the abdominal cavity and the omentum to minimize anesthesiological and surgical aggression and to form and maintain general cavities, as well as to create good access to the pancreatic area. For patients with large-focal, infected subtotal or total pancreatic necrosis and purulent peritonitis, it is advisable to perform laparotomy, abdominalization of the pancreas, necrectomy, omentobursostomy, and drainage of purulent foci in the abdominal cavity and retroperitoneal tissue.
Clinical significance of post-COVID-19 in patients with hypertension, taking into account the polymorphism of genes encoding components of the renin-angiotensin system
Authors: Ryabova A. Yu. , Guzenko T. N. , Bykova A. P.
Published: November 2024

To date, there has been no consensus on the impact of polymorphism of components of the renin-angiotensin-aldosterone system (RAAS) on the course of a new coronavirus infection or a possible role in post-COVID syndrome. The objective is to study the significance of COVID-19 and gene polymorphism encoding components of renin angiotensin system in patients with hypertension. Materials and methods: A clinical examination was conducted on 116 stage 2 hypertensive patients with uncontrolled hypertension. Of these, 96 underwent mild or moderate COVID-19, 51 before 12 weeks and 45 after 12. Results. Patients in the ongoing symptomatic phase of COVID- 19 had higher systolic blood pressure than those with post COVID syndrome (p1-2 = 0.03659, p1-3 ≤ 0,00001).The association of polymorphisms of genes AGT:704T>C, AGT521C>T, AGTR1:1166A>C, AGTR2:1675G>A, CYP1IB2:-344C>T with gender, BMI and COVID-19 transmission has not been identified. In the symptomatic phase of COVID-19, carriage of the TT genotype for the AGT704 gene was less frequent (p=0.005) compared to the control group. Conclusions. The effect of COVID on an increase in blood pressure in stage 2 hypertensive patients was determined. An association between blood pressure instability and BMI after COVID was established. During the symptomatic COVID phase, there was an association between increased blood pressure and the C allele of AGT gene polymorphisms (T704).
Case report of varicose veins treatment in patient with a prosthetic mitral valve
Authors: Ibragimov D. R. , Minigalieva E. R. , Hafizov A. R. , Oleinik B. A. , Murasov T. M. , Kaipov A. E.
Published: November 2024

This clinical case may be of interest in situations where a patient with varicose veins of the lower limbs and concomitant heart disease, who is on long-term anticoagulant therapy and is scheduled to undergo minor surgery, may present the possibility of endovenous laser ablation (EVLA) against the background of warfarin use. Patient, G., 68 years old, with rheumatic combined mitral valve disease (mitral valve replacement in 2019, permanent atrial fibrillation), also had varicose vein disease of the lower limbs. History included acute cerebrovascular accident (19.01.2023). Duplex Ultrasonography Screening (DUS) showed failure of the left great saphenous vein valve. Hypocoagulation was also observed in coagulogram and the risk of bleeding on HAS-BLED score was average. On Caprini score, the risk was very high. Endovenous laser ablation of the large saphenous vein on the left side was performed. During follow-up examinations, there were no signs of bleeding from puncture sites. The target trunk was obliterated in dynamics at DUS. Therefore, it is possible to carry out EVLA of a large subcutaneous vein while taking therapeutic doses of warfarin without switching to bridge therapy. Endovascular laser ablation allowed it to be done with less risk of bleeding and, against the background of taking warfarin, reduced the risk of thrombosis.
Comprehensive treatment of the patient with venous trophic ulcer
Authors: Botashev R. N.
Published: November 2024

Improving the results of treatment for patients with varicose veins in the lower extremities, complicated by trophic ulcers, is an urgent task for modern medicine. A long-term, recurrent course of the disease leads to a reduction in working capacity and deterioration in quality of life, as well as permanent disability for patients, whose treatment causes special economic problems. At present, there are virtually no effective methods for conservative therapy, leading to prolonged unsuccessful treatment of such patients. This article presents the clinical case of a 63-year-old patient undergoing complex treatment for chronic lower limb venous insufficiency of class C6 according to the CEAP classification. Conclusion. An effective complex method for treating trophic ulcers in patients with chronic venous disease involves the correction of venous hemodynamic disorders (in this case, through radiofrequency ablation), as well as primary surgical treatment for the ulcerative defect, and simultaneous autodermaplasty with a perforated skin flap.
Retrospective analysis of ferrotherapy methodology in patients with chronic heart failure and chronic kidney disease
Authors: Makarova N. A.
Published: November 2024

The course of chronic non-infectious diseases is often accompanied by the development of comorbid conditions. In chronic heart failure and chronic kidney disease, special attention is drawn to iron deficiency and anemia. Intravenous iron preparations have become widely used for the prevention and treatment of anemia. Their use contributes to the progression of structural changes in vital organs. However, attempts to implement high-dose intravenous ferrotherapy as a routine strategy for compensating iron deficiency in patients with heart failure, with or without anemia, raise questions related to the search for diagnostic markers of iron deficiency states, goals, and conditions for its use. The article discusses the influences of a combination of opposing factors (inflammation, hypoxia) on the erythron system, its humoral regulators, and iron metabolism based on the author’s own research to justify the choice of strategy and tactics for ferrotherapy in patients with heart failure and chronic kidney disease.
Antonin Frantsevich Lingart and the creation of air ambulance in the USSR
Authors: Krynyukov P. E. , Abashin V. G. , Velichko I. I. , Dulin P. A.
Published: November 2024

The article presents data on the development and creation of the first air ambulance and the participation of A.F. Lingart, the chief sanitary doctor of the Red Army, in this project.
Military doctors: personal tragedies against the background of the Civil War
Authors: Abashin V. G. , Simonenko V. B. , Dulin P. A.
Published: November 2024

The factual data on the tragic events of the Civil War, including “red” and “White” terror, are presented. Biographical information about doctors and nurses from White Army military units and Workers’ and Peasants’ Red Army who were killed, captured, or shot during the war is provided.