bluuebunny/crossref_metadata_2025 huggingface dataset:
A Cytokine-based model for the pathophysiology of Long COVID symptoms
Authors: Low Russell N , Low Ryan J , Akrami Athena
Published: November 2020

The Long COVID group includes patients with mild-to-moderate symptoms, in whom recovery is prolonged, lasting months. Here we propose a model for the pathophysiology of the Long COVID presentation based on inflammatory cytokine cascades and the p38 MAP kinase signaling pathways that regulate cytokine production.In this model, the SARS-CoV-2 viral infection is hypothesized to trigger a dysregulated peripheral immune system activation with subsequent cytokine release. Chronic low-grade inflammation leads to dysregulated brain microglia with an exaggerated release of central cytokines, producing neuroinflammation. Intermittent fatigue, Post Exertional Malaise (PEM), CNS symptoms with "brain fog," arthralgias, paresthesias, and GI and ophthalmic problems can all be attributed to elevated peripheral and central cytokines.There are abundant similarities between symptoms in Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). A post-infectious ME/CFS model involving a dysfunctional peripheral and central cytokine inflammatory response and autoimmunity is emerging. DNA polymorphisms and viral-induced epigenetic changes to cytokine gene expression may lead to chronic inflammation in Long COVID patients, predisposing some to develop autoimmunity, which may be the gateway to ME/CFS.
Pembagian masker
Authors: safitri Arfiana
Published: November 2020

Pembagian masker perlu di adakan karena mengingat covid-19 di indonesia sangat meningkat oleh karena itu kita harus mematuhi protokol kesehatan
SEMINAR KECAMATAN
Authors: Ilman Taslima
Published: November 2020

Kuliah kerja lapang plus (KKLP) merupakan sesuatu kegiatan perkuliahan yang bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh mahasiswa dalam jangka waktu tertentu. Oleh karena, sifatnya instrakulikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strata satu (S1) harus mengikuti KKLP.
PENGADAAN TEMPAT SAMPAH
Authors: Nurmitasari
Published: November 2020

Kuliah kerja lapang plus (KKLP) merupakan sesuatu kegiatan perkuliahan yang bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh mahasiswa dalam jangka waktu tertentu. Oleh karena, sifatnya instrakulikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strata satu (S1) harus mengikuti KKLP.
KERJA BAKTI DAN PENYEMPROTAN DI MASJID
Authors: amalia tiwi
Published: November 2020

Kuliah Kerja Lapang Plus (KKLP) merupakan suatu kegiatan perkuliahan yang bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh mahasiswa dalam jangka waktu tertentu. Oleh karena, sifatnya intrakurikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strata satu (S1) harus mengikuti KKLP.
KULTUM
Authors: Ashari Sri Ayu
Published: November 2020

Kuliah Kerja Lapang Plus (KKLP) merupakan suatu kegiatan perkuliahan yang bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh mahasiswa dalam jangka waktu tertentu. Oleh karena, sifatnya intrakurikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strata satu (S1) harus mengikuti KKLP
PEMASANGAN BATAS LINGKUNGAN,PAPAN KEPALA LINGKUNGAN DAN IMAM LINGKUNGAN
Authors: Nurmitasari
Published: November 2020

Kuliah kerja lapang plus (KKLP) merupakan sesuatu kegiatan perkuliahan yang bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh mahasiswa dalam jangka waktu tertentu. Oleh karena, sifatnya instrakulikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strata satu (S1) harus mengikuti KKLP.
PENGADAAN TEMPAT SAMPAH
Authors: Lisnawati
Published: November 2020

Kuliah Kerja Lapang Plus (KKLP) merupakan suatu kegiatan perkuliahan yang bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh mahasiswa dalam jangka waktu tertentu. Oleh karena, sifatnya intrakurikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strata satu (S1) harus mengikuti KKLP.
PEMASANGAN BATAS LINGKUNGAN,PAPAN KEPALA LINGKUNGAN DAN IMAM LINGKUNGAN
Authors: Ilman Taslima
Published: November 2020

Kuliah kerja lapang plus (KKLP) merupakan sesuatu kegiatan perkuliahan yang bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh mahasiswa dalam jangka waktu tertentu. Oleh karena, sifatnya instrakulikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strata satu (S1) harus mengikuti KKLP.
PEMASANGAN BATAS LINGKUNGAN, PAPAN KEPALA LINGKUNGAN DAN IMAM LINGKUNGAN
Authors: sahar Alfira
Published: November 2020

Kuliah kerja lapang plus (KKLP) merupakan sesuatu kegiatan perkuliahan yang bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh mahasiswa dalam jangka waktu tertentu. Oleh karena, sifatnya instrakulikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strata satu (S1) harus mengikuti KKLP.
PEMBERSIHAN BEBERAPA INSTANSI
Authors: Ashari Sri Ayu
Published: November 2020

Kuliah Kerja Lapang Plus (KKLP) merupakan suatu kegiatan perkuliahan yang bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh mahasiswa dalam jangka waktu tertentu. Oleh karena, sifatnya intrakurikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strata satu (S1) harus mengikuti KKLP
PEMBENAHAN HALAMAN KANTOR LURAH
Authors: Ilman Taslima
Published: November 2020

Kuliah kerja lapang plus (KKLP) merupakan sesuatu kegiatan perkuliahan yang bersifat intrakurikuler dalam bentuk pengabdian pada masyarakat yang dilakukan oleh mahasiswa dalam jangka waktu tertentu. Oleh karena, sifatnya instrakulikuler sehingga setiap mahasiswa yang akan menyelesaikan studi di perguruan tinggi pada suatu program strata satu (S1) harus mengikuti KKLP.
Pembuatan batas kelurahan
Authors: putri Eka
Published: November 2020

Kuliah kerja lapang plus adalah kegiatan perkuliahan yang diwajib dilaksanakan mahasiswa dalam bentuk pegabdian kepada masyarakat
Controlling video stimuli in sign language and gesture research: The OpenPoseR package for analyzing OpenPose motion tracking data in R
Authors: Trettenbrein Patrick C. , Zaccarella Emiliano
Published: November 2020

Researchers in the fields of sign language and gesture studies frequently present their participants with video stimuli showing actors performing linguistic signs or co-speech gestures. Up to now, such video stimuli have been mostly controlled only for some of the technical aspects of the video material (e.g., duration of clips, encoding, framerate, etc.), leaving open the possibility that systematic differences in video stimulus materials may be concealed in the actual motion properties of the actor’s movements. Computer vision methods such as OpenPose enable the fitting of body-pose models to the consecutive frames of a video clip and thereby make it possible to recover the movements performed by the actor in a particular video clip without the use of a point-based or markerless motion-tracking system during recording. The OpenPoseR package provides a straightforward and reproducible way of working with these body-pose model data extracted from video clips using OpenPose, allowing researchers in the fields of sign language and gesture studies to quantify the amount of motion (velocity and acceleration) pertaining only to the movements performed by the actor in a video clip. These quantitative measures can be used for controlling differences in the movements of an actor in stimulus video clips or, for example, between different conditions of an experiment. In addition, the package also provides a set of functions for generating plots for data visualization, as well as an easy-to-use way of automatically extracting metadata (e.g., duration, framerate, etc.) from large sets of video files.
Establishing the transdiagnostic contextual pathways of emotional outbursts
Authors: Chung Justin , Mevorach Carmel , Woodcock Kate
Published: November 2020

Emotional outbursts (also known as temper outbursts) are commonly experienced by people with neurodevelopmental disorders and people who have experienced childhood adversity, which can negatively impact individuals and their families. Emotional outbursts may manifest via different pathways that are related to context-specific differences in the regulation and expression of emotions. Caregivers (N = 268) of young people (6-25 years) with neurodevelopmental disorders and/or childhood adversity completed a newly designed caregiver-report questionnaire. Six contextual factors were derived from the Emotional Outburst Questionnaire. The responses were classified based on these factors into three clusters, which may represent potential pathways of emotional outbursts. The three clusters were characterised by the increased likelihood of outbursts: 1) across all setting events and triggers; 2) in safe setting events; 3) across setting events. These potential pathways might be related to the following mechanisms: 1) differences in sensory processing; 2) masking of emotions in unsafe environments; 3) differences in safety perception. Establishing the potential pathways of emotional outbursts may facilitate the identification of the context-dependent cognitive and emotional differences that distinguish these pathways, which may consequently inform the development of pathway-specific intervention strategies.
General Comments from the Expert Group "Draft ECB Guide on climate-related and environmental risks" (September 2020)
Authors: Braun Benjamin , Claeys Irene , de Arriba-Sellier Nathan , Fontan Clément , Krahé Max , Pistor Katharina , Schreur Valerie , Smoleńska Agnieszka , Solana Javier , Klooster Jens van't
Published: November 2020

This is a general commentary that we submitted to the 2020 Public Consultation on the ECB's Draft ECB Guide on climate-related and environmental risks. Based on our research and collaborative discussions we formulate seven main requests for clarification and suggestions for further improving the current draft and the ECB’s Supervisory Review and Evaluation Process (SREP) that it will inform.
Maíz sólo se come: Contemporary agriculture in Uaxactún, Guatemala
Authors: Adámek Jakub
Published: November 2020

This paper aims to explore agriculture in modern-day Uaxactún, Petén, Guatemala. The results are based on two types of data – spatial and anthropological. Spatial data are represented in the visualization of recent agricultural features (Milpas) visualized from orthophoto maps, processed in QGIS 3.10.1. Anthropological data were obtained during July and August 2019 in the Uaxactún, as a part of the Regional Archaeological Project of Uaxactún (Proyecto arqueológico regional Uaxactún – PARU). 18 respondents had taken part in the research. The research was conducted by semi-structured interviews and participant observation. To list finds – the average Milpa dimension was described, most interesting crops and agricultural techniques were described, and a model of the local agricultural year was provided. The key find is that, even if one could interpret recent Uaxactún agriculture as traditional, the drives and motivations of the farmers are modern, capitalistic, and monetary oriented.
Rethinking Monetary Sovereignty: The Global Credit Money System and the State
Authors: Murau Steffen , Klooster Jens van 't
Published: November 2020

This article proposes a new conception of monetary sovereignty that acknowledge the reality of today’s global credit money system. The concept is today predominantly used to denote states that issue and regulate their own currency. This article rejects that Westphalian understanding of monetary sovereignty. Instead, we propose a conception of effective monetary sovereignty that focuses on what states are actually able to do in the era of financial globalization. The conception fits the hybridity of the modern credit money system by acknowledging the crucial role not only of central bank money but also of money issued by regulated banks and unregulated shadow banks. These institutions often operate ‘offshore’, outside of a state’s legal jurisdiction, which makes monetary governance more difficult. Monetary sovereignty consists in the ability of states to effectively govern these different segments of the monetary system and thereby achieve their economic policy objectives.
The National Sports and Society Survey Methodological Summary
Authors: Knoester Chris , Cooksey Elizabeth C.
Published: November 2020

The 2018-19 National Sports and Society Survey (NSASS) was designed to be a unique social science data collection effort to enable quantitative research on important but under-researched issues. In particular, its intent was to provide comprehensive empirical evidence of sports involvement patterns and contexts, sports-related public opinions and ideologies, and indicators of well-being, social patterns, and the more general social contexts of adult Americans ages 21-65. Respondents were also asked to report on the sports involvement histories and contexts, family and school experiences, and health and well-being of a child between 6 and 17 years old if they had such a child who also shared a residence with them. A targeted sample of 4,000 adults was established using members of the American Population Panel (APP) so that important subgroup analyses could be undertaken, and to allow for follow-up interviews to be conducted with sufficient numbers in today’s climate of declining survey responses. The NSASS was designed and enacted by Prof. Chris Knoester (PI), with support from the College of Arts and Sciences, the Sports and Society Initiative, and CHRR at The Ohio State University. CHRR worked closely with the PI to design the study, navigate Institutional Review Board protocols, construct and polish the survey instrument, program the online interface, and collect, document and disseminate the data. This document summarizes the survey design and data collection efforts of the NSASS.
The Performance Enhancement Attitude Scale (PEAS) reached ‘adulthood’: Lessons and recommendations from a systematic review and meta-analysis
Authors: Folkerts Dirk , Loh Roland , Petroczi Andrea , Brückner Sebastian
Published: November 2020

Research on doping attitude has relied heavily on the Performance Enhancement Attitude Scale (PEAS). Yet, to date, no systematic review and meta-analysis of the PEAS have been conducted. Thus, the purpose of this study is, for the first time, to cumulate evidence for the psychometric properties of PEAS; specifically to conduct a qualitative synthesis and perform a meta-analysis to analyze the available results and findings for internal consistency reliability, gender differences and user/non-user differences in doping attitude assessed by the PEAS. The meta-analysis showed good level of internal consistency reliability for the PEAS. Overall, negative doping attitude characterized the athlete population, regardless of gender or involvement in doping. The latter, coupled with sole reliance on self-reports, questions the validity of PEAS as proxy for indexing doping behavior; and calls for a more nuanced understanding of the role of attitudes toward doping and clean sport behaviour.
Development of Performance Grading Map of Nepal Based on Superpave System
Authors: Kharbuja Sunita , Shahi Thusitha Chandani , Duwal Rajan
Published: November 2020

The Performance of the bituminous binder plays important role in the overall performance of the pavement system. One of the major cause of pavement failure is the bitumen grade, i.e selection of suitable grade of bitumen. Therefore, performance grading of bituminous binder is inevitable for the specific temperature and climatic zones. This study is focused on the determination of performance grading of bituminous binder for various temperature zones in Nepal. In this study, twenty one years’ daily maximum and minimum secondary temperature data of 70 meteorological stations were collected and were analyzed for temperature zoning. Performance grading of bituminous binder was conducted with the help of Strategic Highway Research Program (SHRP) and Long-Term Pavement Performance Program (LTPP) prediction models. The concept of Superpave has been adopted for the analysis, which stands for superior performing asphalt pavement. The Superpave mix design includes a new analysis system based on performance characteristics of the pavement layer. The bituminous binder grades for Nepal have been determined on the basis of air temperature thereafter predicting the pavement temperatures. The study has determined seven different performance grade zones based on SHRP and four different performance grade zones based on LTPP model. The study synthesized the Performance Grade (PG) map of the country.
A Study on Comparison of Index Returns and Returns of Portfolio Created Using Equal Weight Age Index Method
Authors:   Happy Valley Business School Coimbatore, Prakash A. Arun
Published: November 2020

The main aim of the study is to select a list of companies from the basic indices of NSE like Nifty50, Next50 and Small Cap 50, to create a portfolio of the companies with respect to the indices selected for the study which results in 3 different portfolios. Portfolio 1 represents 29 scrips selected from Nifty50, Portfolio 2 represents 30 scrips selected from the Next50 index, and Portfolio 3 represents 34 scrips selected from Small Cap index. After creating the portfolios, Each scrip under each portfolio will be invested with Rs.1,00,000, each scrip in each portfolio will be given equal weightage so the total investment will be Rs.29,00,000, Rs.30,00,000 and Rs.34,00,000, under Portfolio 1, 2 and 3 respectively. To prove the factor that the returns of the created portfolio has beaten the index returns the price data of all the scrips for the past 10 years were taken and the returns were computed for the portfolio year on year and from 2008 to 2018. Keywords: Index Returns, Returns of Portfolio, Equal Weight Age Index Method
Corruption and Covid-19’s Lethality: “So What?”
Authors:   Federal University of Pernambuco, Brazil, Barros Arthur do Nascimento Ferreira , Santos Lucas Libini Ramos dos ,   Federal University of Pernambuco, Brazil, Bernardo Raul Antonio de Lemos ,   Federal University of Pernambuco, Brazil, Xavier Louise de Oliveira ,   Federal University of Pernambuco, Brazil, Cavalcanti Anna Gabryella do Carmo Trajano ,   Federal University of Pernambuco, Brazil
Published: November 2020

We aim to verify if there is an association between the level of corruption and the lethality on countries due to COVID-19 pandemic. Previous studies provide evidence that corruption can harm health outcomes, especially in developing and under-developing countries where resources are already scarce. We apply a strictly quantitative approach using dispersion graphics analysis and Pearson’s correlation on 171 countries. On countries from America, Africa, Asia and Oceania we observed that as more corrupt the country, higher its lethality, although in Europe this association is inverted. We attribute this last result to the continent possess the elderly population among other continents, the fact that countries loosened to earlier measures of physical distancing and cases of corruption were reported in some countries with a low perception of corruption. Therefore, corruption remains an issue that needs more understanding so we can decrease its effects on health outcomes and save lives, particularly in countries with weak healthcare systems. Besides, the next pandemic is coming and we need to be prepared. Keywords: Corruption, Healthcare system, Health outcomes, COVID-19, Lethality.
R & D and Internationalization: Effect on the Performance of SMEs
Authors:   School of Strategy and Business, UT Toronto, Canada, Chalmers David K. , Mannetta Emily W. ,   School of Business, CAU Atlanta, U.S.A., Sensini Luca ,   R & D and Internationalization: Effect on the Performance of SMEs
Published: November 2020

The purpose of this research is to study the impact of research and development activities on the performance of SMEs operating in non-high-tech sectors. At the same time, this study also investigates the impact produced by internationalization on research and development activities and performance. This choice is driven by the fact that there are several studies focusing on large companies and high-tech companies, while only a few scholars have addressed this topic for non-high-tech SMEs. A sample of Italian companies was chosen to develop the survey. The companies interviewed were obtained from the Amadeus database, in accordance with the definition of SMEs of the European Commission. From all the population, we extracted a probabilistic sample based on stratified random sampling design. Data collection and information was carried out through a questionnaire. The use of this tool has made it possible to collect updated information on research and development, innovation, internationalization and other general aspects useful for research purposes. The results show that non-high-tech SMEs that invest in research and development get performance benefits up to an optimal level of investment. In addition, the results suggest that internationalization can increase performance. Keywords: Innovation, R&D, Internationalization, Performance, SMEs.
Micellar and Transition Metal Ion Catalysed Oxidation of Pentanol in Aqueous Medium
Authors: Acharjee Animesh , Rakshit Atanu , Chowdhury Suman , Saha Bidyut
Published: November 2020

Micelles and 4d- or 5d-transition metal ions have been proved to be effective catalysts for the oxidation of 1-pentanol by Ce(IV) in aqueous medium under pseudo 1st order reaction conditions at 258C. Although cationic micelles show a speed retarding effect, anionic SDS micelles accelerate the reaction rate. The Ir(III) and Ru(III) catalysed reactions show shorter half-lives at micromolar concentration. Active Ce(IV) species are also identified and an explanation of the different catalytic activities of metal ions and micelles is presented. The accumulation of the substrate in the Stern-layer of the SDS micelles is detected. The reaction product is confirmed by melting point analysis, a 2,4-DNP test, and by IR and NMR studies.
Prospecção de extratos vegetais como coadjuvantes de higiene bucal em cães raça Labrador Retriever
Authors: Zanini Marcos , de Carvalho Amorim Bolzan Thays , Aparecida Severi Juliana , Cecília Oliveira Villanova Janaina , Molinari Donatele Dirlei , Madureira Ana Paula
Published: November 2020

The present study aimed to prospect plant extracts as a therapeutic resource, compared to the oral microbiota of dogs. For this purpose, ethanol extracts from different parts of Anacardium Ocidentalis (cashew tree), Stryphnodendron adstringens (barbatimão), Punica granatum (pomegranate), Uncaria tomentosa (cat's claw), Psidium guajava L. (guava), Momordica charantia L. (melon from São Caetano) and Harpagophytum procumbens (devil's claw), prepared in different concentrations. Microorganisms collected from the oral mucosa of 12 Labrador dogs, maintained under the same management and feeding, were seeded in BHI Agar in a petri dish in which paper disks impregnated with 20µL of each extract were circulated. 0.12% chlorhexidine digluconate solution was used as a positive control. The plates were incubated for 12 hours at 36 ºC. Three swabs were collected for each animal and each experiment was carried out in triplicate. The results of the inhibition halo measurements were subjected to the Kruskall-Wallis analysis of variance, followed by the Dunn test, with a significance level of 5%. Based on the results, pomegranate, guava, and barbatimão extracts were selected, as they were statistically significant at concentrations of 250; 125; 62,6mg/mL which suggests that the three are potential candidates for use in the development of pharmaceutical products for use in oral hygiene of dogs.
Consumidores de ovos: Perfil y preferência na cidade de Pedro Juan Caballero, Paraguai
Authors: Lesmo Duarte Nelson , Vega Britez Gustavo Daniel , Velázquez Duarte José Augusto
Published: November 2020

This investigation aimed to verify the profile and preference for egg consumption in the city of Pedro Juan Caballero. A type of survey was implemented, with the sample consisting of 140 people. The results showed that 62.2% of the interviewees were female, with 49.3% of age between 15 and 35 years old, with 80,0% being university students and 74.3% receiving a minimum wage. In total, 97.9% confirm consuming the egg. In choosing, the color of the eggshell does not influence the age, sex, education and income level of the interviewees. However, according to sex, education, the color of the skin exhibited influence in the quality. The consumption of eggs according to the respondents' education is related to some diseases. According to the research, it is shown that the egg is part of the daily diet of the population, however, the belief about its relationship with some diseases persists, despite being refuted by science, a situation that must be addressed through marketing strategies to avoid this perception.
Geological justification for increasing the efficiency of development of deposits of hard-to-recover oil reserves in the collectors of the Tyumen arch of the Surgut (Western Siberia)
Authors: Bembel S. R. , Avershin R. V. , Bembel R. M. , Kislukhin V. I.
Published: November 2020

The article deals with the results of studies of the geological structure features of the US2 oil-bearing stratum in the upper part of Tyumen suite (a case study of the Surgut arch fields). Object US2 is represented by low-permeability reservoirs with complex facies variability and an uneven distribution of reservoir properties over area and section, characterized by a thin-layered structure. In this regard, the oil reserves of the US2 structure are naturally classified as hard-torecover, requiring additional work to further study its structure and features for effective development of oil reserves. The facies of river channels, riverbank shoals and sands of floodplain spills were identified, based on the analysis of geological and geophysical materials: 3D seismic survey, core studies, well testing data, sampling and dynamics of wells operation in the area of the deposits in the upper part of the US2 horizon. Based on the analysis of the detailed correlation, three types of section of the US2/1 formation were identified, differing in the nature of the reservoir spread. Based on the 3D seismic survey data, in order to clarify the structure of the US2 formation, a dynamic analysis of the attributes of the seismic record was carried out. Significant coefficients of cross-correlation between the dynamic characteristics and production parameters of the US2/1 formation were not obtained. It is necessary to develop optimal methods for exploration and clarification of the features of the geological structure and forecasting the distribution of reservoir properties, rational methods and approaches to the development of hard-to-recover reserves of Tyumen suite objects with a complex distribution of reservoir properties and variability of productive thicknesses.
Experiencing Graduated Intimacies during Lockdown (Fengcheng)
Authors: Chen Junjie
Published: November 2020

In this article, I examine the ways in which the recent, nationwide ‘lockdown’ (fengcheng) in China, caused by the unprecedented COVID-19 pandemic, has abruptly reshaped daily intimacy practices of urban residents. Highlighting the lockdown in a southeast coastal city in the broader context of China’s post-socialist transformations, I propose that class distinctions have profoundly reconfigured local citizens’ daily experiences, producing a system of what might be termed ‘graduated intimacies’. To further contextualize these urban citizens’ experiences of intimacy under the current transnational geo-biopolitics associated with the pandemic, I provide a reflexive and comparative ethnographic look at the national capital of Beijing. In so doing, I offer a glimpse into the lives of several sets of Chinese citizens at an unexpected historical moment induced by a grave public health crisis extending well beyond China’s national borders.
Constructing the Not-So-New Normal
Authors: Kurnosov Dmitry , Varfolomeeva Anna
Published: November 2020

This article examines the early evidence for the emergence of new governmental regulations of intimacies during the COVID-19 pandemic based on the authors’ experience of hospital treatment in Russia. It discusses the increasingly used notion of ‘the new normal’ and its potential implications for citizen–state relations. Approaching these emerging regulations from both legal and anthropological perspectives, the authors propose the alternative concept of ‘the not-so-new normal’, which combines discursive ambiguity with familiar patterns of control. The notion of lawscape is used to systematise the bodily control practices inside and outside a Russian hospital and to place them in a wider context. Applying the concept of rupture, the authors claim that ‘the not-so-new normal’ obfuscates the break with pre–COVID-19 reality to reinforce existing hierarchies and inequalities.
EVALUATING THE EFFECTIVENESS OF PRIMARY ANALGESIC AND SUBSEQUENT COMBINED MET–THERAPY IN RENAL COLIC THERAPY
Authors: Ivashchenko D.M. , Dudchenko M.O. , Kravtsiv M.I. , Shevchyk M.P.
Published: November 2020

Renal colic is an acute pathological symptom complex, which, despite all the achievements of medicine, demonstrates constant occurrence rate of about 12% in the human population. This condition is characterized by a pronounced sudden pain attack, which causes significant suffering to the patient. Therefore, the search for effective and safe methods of analgesia and the search for ways to correct urinary obstruction as a cause of pain are of great clinical importance. The aim of the study was to assess the effectiveness of analgesic and combined lithoeradicative therapy to improve the management of patients with acute attack of renal colic. The clinical study included 228 individuals admitted to the hospital with a diagnosis of renal colic. At the first stage, they were divided into three groups to assess the effectiveness of the pharmacological management of primary analgesia. At the second stage, 96 patients were examined, and then divided into 2 subgroups in order to assess the effectiveness of medical expulsive therapy in its mono–variant and in combination with spasmolytics. The results obtained demonstrated that during the primary analgesic therapy of renal colic, non–steroidal anti–inflammatory drugs have advantages over the opioid group that is manifested by a stronger analgesic effect and less severe adverse reactions. Diclofenac showed the best results in pain relief, superior to other drugs by 5–7%. When evaluating the effectiveness of combined medical expulsive therapy, the data obtained indicate an increase in the chances of calculi passage by 11% in the group, which received drotaverine additionally to the therapeutic scheme, and, consequently, a decrease in the number of patients requiring further surgery. This group also demonstrated a pain reduction by 6–7%. Summarizing the data obtained, we can recommend the administration of diclofenac in a dose of 75 mg for primary analgesia of renal colic, and when conducting medical expulsive therapy, combine α–blockers and spasmolytics should be applied. This will lead to improved clinical results in patients with renal colic.
RELATION BETWEEN GLUCOCORTICOID RESISTANCE AND GLUCOCORTICOID RECEPTOR GENE BclI-POLYMORPHISM AND SOME CYTOKINE PROFILE PARAMETERS IN PATIENTS WITH HAND ECZEMA
Authors: Methkal A. M.
Published: November 2020

Though glucocorticoids are widely used in dermatological practice, some patients with hand eczema may have resistance to glucocorticoids, even when they are taken in heavy doses. Glucocorticoids mediate their actions through glucocorticoid receptors. Polymorphism of the glucocorticoid receptor gene (NR3C1) can inhibit the cellular response to glucocorticoids and lead to reduced response to the therapy. Some cytokines can affect the production of various glucocorticoid receptor subunits, modulating the cell response to glucocorticoids. However, there is still need in detailed study of pathogenetic mechanisms and the detection of highly specific predictors of glucocorticoid resistance. The aim of this work was to investigate the possible relation between glucocorticoid resistance in patients with hand eczema, rs41423247 SNP, and blood concentration of interleukin-17A and interleukin-2. The venous blood of 143 patients with hand eczema (42% of women and 58% of men) mean age 42.2 ± 11.1 years was taken for the study. During the patients examination the data on age, sex, body mass index (kg/m2), body mass index ≥ 25 (kg/m2(%)), the habit of smoking, concemtration of immunoglobulin E (iu/ml), interleukin-17A (pg/ml) and interleukin-2 (pg/ml) were obtained. The еczema аrea and severity index was assessed in each subject before the therapy and in two weeks since the therapy started. According to index value, all the patients were divided into three subgroups: mild eczema, moderate eczema, and severe eczema. Patients with mild and moderate eczema were prescribed to apply topical glucocorticoid 0.1% mometasone furoate cream twice a day for 2 weeks. The patients with severe hand eczema were prescribed to receive additional systemic corticosteroid, a solution of dexamethasone by intramuscular injection in a dose of 8 mg / day, then 4 mg / day for another 2 days. BclI SNP (rs41423247) of the glucocorticoid receptor gene (NR3C1) was determined using PCR-RFLP method. The quantitative variables were tested for normal distribution by the Shapiro-Wilk test. The comparisons of the means between the two subgroups were performed by Student's t-test for independent samples. The comparison of the frequencies distribution in the subgroups was calculated by using the Pearson test. The P value < 0.05 was considered as significant. Thus, the obtained results revealed that insensitivity to glucocorticoids in patients with hand eczema is related to NR3C1 gene Bcl-1 polymorphism, eczema severity and plasma level of interleukin-17, interleukin-2. The plasma content of interleukin-17 and interleukin-2 in patients with glucocorticoid resistance was significantly higher compared to hormone-sensitive subjects. There were significantly more people with the C/G- and G/G genotypes in the group that did not have a clinical response to therapy.
COMPARISON OF SHORT-TERM AND LONG-TERM COURSE OF ANTIBACTERIAL THERAPY FOR INTRA-ABDOMINAL INFECTION CAUSED BY ACUTE GANGRENOUS APPENDICITIS
Authors: Shevchuk M.P. , Dudchenko M.O. , Ivashchenko D.M. , Kravtsiv M.I.
Published: November 2020

Intra-abdominal infection and its complications is still remaining a fairly common and urgent global problem. Currently, there are a large number of publications providing guidelines and recommendations for the treatment of infections caused by a certain type of causative agents. However, the appropriate duration of antibiotic therapy is among the most controversial issues. Majority of clinicians tend to prescribe antibiotic therapy until all signs of inflammation disappear, usually for 7-14 days. But, in 1994, Schein M., and co-authors suggested that with adequate treatment of the focus of intra-abdominal infection, the duration of antibiotic therapy can be reduced to 3-4 days that in turn will reduce the resistance to antibacterial drugs. The aim of this study was to investigate the possibility in reducing antibiotic therapy length for patients with intra-abdominal infection caused by acute gangrenous appendicitis. The study included 32 patients aged 18 - 65 years, who were operated on for acute gangrenous appendicitis at the same day when admitted to the hospital at the surgical department of the 3rd Municipal Clinical Hospital of Poltava. The patients were divided into two groups. The first (study) group included 16 patients who received antibiotic therapy within minimum 3 days until the normalization of the leukocytosis and body temperature. The second (control) group included 16 patients who continued to receive antibiotic therapy for at least 2 days following the normalization of these criteria. Based on the results obtained in studying the effect of the length of antibiotic therapy course on intra-abdominal infection in the patients with acute gangrenous appendicitis during the postoperative period, we revealed the duration of antibiotic therapy for 3 ± 0.25 days showed similar results compared to the results of traditional and longer antibiotic therapy. The comparable values included periods of recovery and discharge following the surgery, the incidence of complications in the early and remote postoperative period. Our data confirm the concept that adequate surgical treatment of the infection focus in the abdominal cavity results in the reduction of antibiotic therapy length for several days after the operation without the risk of developing postoperative complications and recurrence of the infectious process.
STRUCTURE AND MECHANOGENESIS OF LONG BONE FRACTURES IN LOWER EXTREMITIES DUE TO FALL
Authors: Sokol V.K.
Published: November 2020

Background. The study of the structure and mechanogenesis of falls is necessary to elucidate causal relationships in criminal catatrauma. Purpose of the study was to analyze the structure of mechanical injury resulting in fractures of the long bones of the lower extremities, and the mechanisms of their formation in victims as a result of a fall, according to the primary forensic examination. Material and methods. The study was carried out based on 130 reports of primary forensic examinations of victims with fractures of the femur and / or shin bones due to mechanical injury for the period February – June 2018. All victims were divided into 4 groups: group 1 included individuals sustaining mechanical injury; group 2 involved individuals sustaining injuries in car accidents; group 3 included patients with traumas from the fall, and group 4 included individuals with gunshot fractures. The methodology of the study was based on applying retrospective analysis, descriptive statistics. Results. In cases of catatrauma, the proportion of fractures of the lower extremities makes up 52%, while the proportions of fractures of the upper limbs, ribs and pelvic bones constitute 16% each; in case of car accident the fractures of low legs make up 82.1%, while the fractures of the upper limbs, ribs and pelvic bones constitute 7.8%; 2.4% and 7.7% each, respectively. There are two types of catatrauma included found out in this study: 1) household falls from the own body height (n = 4), and 2) falls from the height not exceeding 3 m (n = 9). The catatrauma mechanisms included the following: 1) active free uncoordinated fall from the own body height with the phase of primary collision with some isolated primary direct injuries; 2) passive free direct predominantly uncoordinated fall from a height of up to 3 m resulting in multiple combined injuries in the phase of primary collision (n = 4), and in the phases of primary and secondary collision of the body (n = 3). Conclusions. In the structure of mechanical injuries of the long bones in the lower extremities according to the initial forensic medical examination, falls from various heights rank the second position among the most frequent criminal injury (10%) after road traffic injuries (89,2%). Falls from own body height and from the height of up to 3 m were free, straight, and mostly uncoordinated, resulted in mainly primary direct injuries as the fractures of the long bones of the upper and lower limbs, ribs, pelvis, brain concussion, chest bruises and abdominal traumas.
EFFECT OF LEPR AND GR GENE POLYMORPHISMS ON HEALTH STATUS OF MOTHERS WITH METABOLIC DISORDERS AND THEIR NEWBORNS
Authors: Pokhуlko V.I. , Cherniavska Yu.I. , Tsvirenko S.M. , Rossokha Z.I. , Klymchiuk Yu.Yu.
Published: November 2020

The high prevalence of obesity and metabolic syndrome throughout the world over the past two decades provided the grounds to the WHO to consider overweight as a non-infectious pandemic. Among the factors that negatively affect the metabolism, result in metabolic disorders and obesity there are genetic, prenatal, diet-related, somatic, psychogenic and others. Analysis of LEPR and GR gene polymorphisms among mothers and their newborns can be an important component in the prediction of metabolic disorders and obesity. The aim of this study was to analyze the presence of clinical and genetic determinants of metabolic syndrome in mothers and their newborns. Materials and methods. A cross-sectional study of 42 pairs of mothers and newborns was performed; we analyzed their anthropometric, clinical and laboratory parameters and, in particular, 2 types of genetic polymorphisms (LEPR rs1137101 and GR, BClI polymorphism). The main group consisted of 15 mother-child pairs, where the woman was clinically obese (body mass index more than 30), the comparison group included 27 mother-child pairs, where the women were overweight (body mass index more than 25). Results. Obese mothers were significantly more likely to have a miscarriage (p = 0.01). Children from obese mothers had significantly higher percentiles of birth weight compared to the control group (60.9 ± 7.7 and 49.75 ± 4.5, respectively, p = 0.05). The GG genotype of the GR gene was associated with more common indications for hospitalization (p = 0.012), rapid delivery (p = 0.01), umbilical cord entanglement around the neck of the foetus (p = 0.012). Among the children- carriers of the GG BclI genotype GR, cardio-metabolic disorders detected by the auscultation of the heart (arrhythmia, functional noise) were found out as significantly more frequent (p = 0.003). Conclusion. The study did not find the associations between LEPR and GR gene polymorphism in obese mothers and the development of overweight in their children, but the study revealed an adverse effect of polymorphic variants on obstetric and gynaecological status of mothers, labour and adaptation of infants in the early neonatal period.
FEATURES OF OCCLUSAL THERAPY IN FUNCTIONAL DISORDERS OF TEMPOROMANDIBULAR JOINTS
Authors: Makeev V.F. , Rybert Yu.O. , Shybinskyy V.Ya. , Kliuchkovska N.R. , Kyrmanov O.S.
Published: November 2020

Temporomandibular joint (TMJ) dysfunctions are known as being highly prevalent, having multifactorial etiology, progressive course, and high recurrence rate. This combination of features typical of this pathology places it among pressing medical issues nowadays. The variety of concepts and approaches to the analysis of the etiopathogenesis of TMJ dysfunction causes a particular interest in both highly informative diagnostic techniques and functional methods of treatment. A complex pathological morphofunctional syndrome involving parafunctions of masticatory muscles, dysfunctional TMJ states and occlusal disorders ultimately leads to deformation and a low functional disproportion in the TMJ kinetics. The work analyzes the reports on the research of various occlusal splints, and in particular, the mechanism of their action, classification of their effectiveness in various types of TMJ disorders, advantages, and disadvantages of splints, as well as materials used for their manufacturing. It is important to emphasize that the choice of the optimal therapeutic approach to internal TMJ disorders should be chosen taking into account the position of the mandibular condyle, the nature of the articular disk displacement, the presence or absence of pain, its possible causes, and concomitant local and general aggravating factors. The study was performed as a part of the research project of the Department of Orthopaedic Dentistry, Danylo Halytskyi Lviv National Medical University.
EVALUATION OF CEPHALOMETRIC ANALYSIS IN PATIENTS WITH BILATERAL CONDYLAR RETROPOSITION IN TEMPOROMANDIBULAR DYSFUNCTION
Authors: Vovk V.V. , Nespriadko V.P.
Published: November 2020

Relevance. During the dentoalveolar growth and development, the direction and growth type of facial skull play a very important role. Development of esthetical symmetry, functional relationship, and clinical disharmony depends on skull parameters. Temporomandibular joint dysfunction is one of the most common diseases nowadays. That is why early identification of risk factors is among the priorities. This study aimed at evaluating occlusional and skeletal specific characteristics in patients with temporomandibular joint dysfunction, comparing different cephalometric findings and CT findings relating to condylar position. Materials and methods. The study included 45 individuals. The study group consisted of 26 patients with bilateral condylar retroposition. Control group was made up of 19 patients. The participants underwent clinical examination, functional testing, palpation of masticatory muscles, occlusion diagnosis by applying Baush articulating film 200,100,8 microns, cephalometric analysis: Tweed, Kim, Jarabak, Ricketts, computed tomography of temporomandibular joint. Statistical analysis was carried out by the program IBM SPSS Statistic Base v.22. Results. There were no pathological contacts during evaluation of static and dynamic occlusion, laterotrusion as «canine guidance». The patients of the test group had bilateral posterior joint fissure reduced right-median 1,96, left-median 1,81. In control group the position was right-average 2,75 and left-median 2,67 The patients in the control and test groups the indices Tweed <FMA average were 19,6°/ median 21,7°; <IMPA average 97,9°/ median 97,8°; Kim ODI median was 68,9°/73,74°; Ricketts Overbite median 2.1 mm /1,9 mm, Overjet median was 2,9 mm /2,85 mm, PM-Xi-ANS median was 44,1°/43,75°, <NPog-FH median was 91°/86,85°,<NBa-PtGn median was 91,1°/90,1°, <MeGo-FH median was 18,7°/22,4°; Jarabak <N-S-Ar average was 127,2°/125,6 °. Conclusions. In the patients with bilateral condylar retropositionm the joint fissure is reduced. Cephalometric analysis demonstrated the following: Tweed <FMA, <IMPA; Kim ODI; Ricketts Overbite, Overjet, PM-Xi-ANS, <MeGo-FH; Jarabak <N-S-Ar can not be used as diagnostic criteria of bilateral condylar retroposition. Ricketts <NPog-FH in the test group showed the mandibular retroposition, but with normal type of mandibular growth <NBa-PtGn. It can be used as one of the primary cephalometric diagnostic indicator of bilateral condylar retroposition.