bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPACTO DAS FRAUDES CONTÁBEIS NO BANCO PANAMERICANO SOBRE A REPUTAÇÃO DA DELOITTE
Authors: Homero Jr. Paulo Frederico
Published: January 2015

A literatura aponta dois incentivos básicos para a qualidade dos serviços de auditoria: os riscos de litígio e os riscos de reputação associados à falta de qualidade nestes serviços. Este artigo tenta identificar se houve danos à reputação da Deloitte em decorrência do anúncio de fraudes contábeis no Banco Panamericano, avaliando as reações do mercado de capitais brasileiro a este evento. Para tanto, duas estratégias foram adotadas: estudo de eventos e teste de Chow. A amostra analisada foi composta pelas ações do índice Ibovespa em 09/11/2010, data do anúncio das fraudes no Banco Panamericano. Os testes estatísticos não deram suporte às hipóteses de que as ações de companhias auditadas pela Deloitte tiveram retornos anormais negativos nem retornos anormaismenores do que as de companhias auditadas por outras firmas durante o período próximo a esta data, e tampouco à hipótesede que ocorreramrompimentos nas tendências dos retornos das ações de companhias auditadas pela Deloitte em maior proporção do que os ocorridos com ações de companhias auditadas por outras firmas. Estes resultados contrariam os verificados em contextos semelhantes em outros países, e parecem indicar que os auditores brasileiros não enfrentam riscos de reputação significativos. Dado que os riscos de litígio enfrentados por estes profissionais no país também são baixos, os resultados apontam uma falta de incentivos à qualidade das auditorias no Brasil.
A divulgação de informação sobre o risco: um caso de grandes empresas portuguesas e espanholas do setor do retalho alimentar
Authors: Alves Teresa , Silva Anabela Maria Martins
Published: January 2015

A gestão do risco é uma atividade reconhecida como fundamental, sobretudo, em contextos de grande incerteza como a atual. Ora, a eficácia na execução dessa atividade depende, entre outros aspetos, da disponibilidade da informação. O objetivo do presente estudo consiste na análise da divulgação de informação sobre o risco nos relatórios e contas de grandes empresas do setor do retalho alimentar em Portugal e em Espanha durante o período de 2008 a 2010. Pretende-se verificar se existe relação entre as variáveis dimensão e risco e o nível de divulgação de informação sobre o risco efetuado nos relatórios e contas destas empresas. Para o efeito adota-se o método “estudo de caso” e recorre-se à análise de conteúdo aplicada aos documentos referidos. Verifica-se que, entre as empresas analisadas, as que divulgam mais informação sobre o risco são as portuguesas. Constata-se, ainda, que qualquer das empresas apresenta um maior nível de divulgação de informação sobre o risco financeiro do que sobre o risco não-financeiro e que não parece existir relação entre a dimensão ou o risco e o nível de divulgação de informação sobre o risco.
COMPARAÇÃO DE DUAS METODOLOGIAS DE APURAÇÃO DO CUSTO DE CAPITAL DAS DISTRIBUIDORAS DE ENERGIA ELÉTRICA BRASILEIRAS
Authors: Vancone Carvalhaes Marina , Aparecido de Albuquerque Andrei , Mendes da Silva Denise
Published: January 2015

O presente trabalho buscou comparar o custo de capital apurado por um dos métodos tradicionais da Teoria de Finanças e aquele estimado pela ANEEL (Agência Nacional de Energia Elétrica), por meio da investigação dos fatores que podem levar a possíveis variações. Trata-se de uma pesquisa básica, bibliográfica e documental, com abordagem quantitativa. O estudo baseou-se na comparação do WACC (Weight Average Cost of Capital – Custo Médio Ponderado de Capital) obtido para as maiores empresas distribuidoras de energia elétrica brasileiras dos cinco maiores  grupos econômicos, de acordo com o Market Share, em oito trimestres analisados, entre o início de 2010 e o final de 2011, conforme os diferentes métodos. Os resultados mostraram que há discrepância entre os métodos estudados. Destacam-se, também, ocorrências de diferentes comportamentos entre as empresas analisadas. Os dados apurados pela metodologia da ANEEL mostraram-se mais constantes, pois suas variáveis estiveram sujeitas a menos variações. Entretanto, o método tradicional, apesar de estar exposto a maiores oscilações entre os períodos, reportou um comportamento mais parecido com o real.
Lembranças do mestre MASAYUKI NAKAGAWA (1928-2014)
Authors: Scarpin Jorge Eduardo , Panhoca Luiz
Published: January 2015

Lembranças do mestre MASAYUKI NAKAGAWA (1928-2014)
Ficha Catalográfica
Authors: Scarpin Jorge Eduardo
Published: January 2015

Ficha Catalográfica
Instruções aos Autores
Authors: Scarpin Jorge Eduardo
Published: January 2015

Instruções aos Autores
Eduardo Lourenço e a terceira margem do Brasil: um olhar português sobre o sertão
Authors: Polese Edna Da Silva , Koehler Jaqueline
Published: January 2015

O olhar português sobre o Brasil incita nosso imaginário, seja sobre questões iluminadoras ou ressentidas entre as duas nações.  Vários ensaios de Eduardo Lourenço na obra A nau de Ícaro debruçam-se sobre essas questões. Dentre essas, a leitura de “Guimarães Rosa e o terceiro sertão” proporciona esse olhar do crítico português inicialmente sobre um momento considerado fundamental para a independência de nossa literatura: a semana de Arte Moderna de 1922. Adiante, relaciona esse acontecimento a obras fundamentais que focam o espaço conhecido como sertão, misto de espaço físico e construção imaginária-simbólica.  Será na obra de Guimarães Rosa que essa construção será conduzida à hora zero, termo do utilizado pelo crítico para anunciar a importância da obra roseana.
O neorrealismo segundo o jovem Eduardo Lourenço
Authors: Bueno Luís
Published: January 2015

No prólogo de seu livro Sentido e forma da poesia neo-realista, Eduardo Lourenço faz a seguinte afirmação: “O 'neo-realismo' como significativa realidade literária nasceu após a sua teorização, como vestimenta de uma Ideologia cuja força histórica, sugestão e potencial universalidade, a exigiam”. Pertencente à geração que construíra aquele amplo debate teórico, mas mais jovem do que seus principais representantes, Lourenço entra na discussão noutra situação, quando já há um conjunto expressivo de obras a serem discutidas. Neste trabalho tratamos dos primeiros artigos críticos de Eduardo Lourenço, publicados na revista Vértice de Coimbra, em que analisa romances de Carlos de Oliveira e Fernando Namora, assinalando sua importância, mas já estabelecendo uma discussão franca sobre os limites do movimento que, àquela altura, iniciava seu percurso rumo a uma posição de hegemonia nas letras portuguesas.
Aplicação das ferramentas da qualidade em um aviário de frango
Authors: Dos Reis Guilherme , Mazureka de Abreu Jordão , Dos Santos Lucas , Mazzuchetti Roselis Natalina , Peterson da Rocha Rony
Published: January 2015

O objetivo do trabalho é aplicar as ferramentas da Qualidade no aviário de frangos para identificar possíveis causas da mortalidade de frangos, buscando minimizar perdas e consequentemente maximizar lucros. Foram aplicadas ferramentas simples que demonstraram o problema durante o período de formação de um lote, 45 dias, por meio de gráfico de sequência. Os dados foram estratificados e as causas vitais foram separadas das triviais com a utilização do Diagrama de Pareto. Os dados revelaram que a causa principal da mortalidade foi o Descarte de frango por má formação genética. Utilizando o Diagrama de Ishikawa, por meio de brainstorming, observou-se que as causas que afetam o problema, genética, matrizes novas e distância do matrizeiro da propriedade, são geradas pelo fornecedor que fornece os pintinhos. E, portanto, incontrolável pela propriedade em estudo. A sugestão para solucionar o problema foi de mudança de fornecedor ou maior intervenção com o fornecedor atual para melhoria do produto. Espera-se que este estudo forneça subsídio para busca de solução de problemas em diversos setores, lembrando que ferramentas podem e devem ser adicionadas para maior precisão da informação.
O uso das usinas hidrelétricas como uma energia renovável
Authors: Freitas Tessarolo Pedro Henrique , Grego Nuss Artur Eugenio , De Almeida Tabachini Guilherme , Barros Negrão Pedro Henrique
Published: January 2015

Esta tese tem o objetivo de demonstrar os elementos que constituem a forma de energia renovável utilizadas por uma usina hidrelétrica. De forma a demonstrar  como pode atuar sobre o meio ambiente, destacando os pontos de vista positivos e negativos, as implantações e as decorrentes tem como objetivo deixar claro as  vantagens e desvantagens desta forma eficiente e renovável de se produzir energia. Assim verificando a utilização das usinas hidrelétricas de forma não degradante ao meio ambiente. Os procedimentos metodológicos usados foram pesquisa bibliográfica e documental.
Sistema Eletrônico de Revistas da UFPR
Authors: Freitas Duarte Maria do Carmo
Published: January 2015

Sistema Eletrônico de Revistas da UFPR
DIFFERENCE AND THE ESTABLISHMENT: AN ASIAN CANADIAN SENIOR PASTOR’S EVANGELICAL SPATIALITY AT TENTH AVENUE ALLIANCE CHURCH IN VANCOUVER, BC
Authors: Tse Justin K. H
Published: January 2015

This paper explores how the evangelical spatiality of an Asian Canadian senior pastor at a historically Anglo-Saxon congregation has transformed it from an ethnically homogeneous, aging church to a heterogeneously-constituted gathering in an evangelical Protestant tradition. This piece challenges the conventional wisdom of the church growth movement and the new religious economics in the sociology of religion, both of which advise religious groups to construct homogeneity and consensus in efforts for numerical growth over against secularizing forces. The paper argues instead that Pastor Ken Shigematsu’s evangelical spatiality from the mid-1990s to the present must be understood as a theological embrace of difference in a church gifted to him by God over which he prayerfully pastors along with his staff. This paper understands Shigematsu’s evangelical spatiality through his own New Testament exegesis, his denominational affiliation with the Christian and Missionary Alliance, his ancient spiritual practices of indiscriminate hospitality, and his mystical reception of Tenth as a welcoming space toward a multiplicity of ethnic, class, and religious backgrounds. This article contributes to Asian Canadian Christian studies by discouraging a future where pan-Asian churches in Canada are homogeneously constructed and by exploring the concrete possibility of non-strategies in which heterogeneous, complex spaces that include Asian Canadians are received by pastors and studied by academics as a divine gift.
FORÇAS ARQUETÍPICAS E SUAS SOMBRAS PROJETADAS NO ESPAÇO
Authors: Schlögl Emerli
Published: January 2015

O presente artigo aborda a Geografia da Religião em diálogo com a Psicologia Analítica de Jung. Discorremos sobre arquétipos e sobre as projeções inconscientes, principalmente formadas por elementos que constituem o que Jung denominou de sombras, e que podem influenciar na conformação de espacialidades religiosas, imprimindo-lhes características peculiares. Para tanto, localizamos e conceituamos o símbolo apontando para a sua importância no estudo e pesquisa da Geografia da Religião. Diferenciamos o símbolo do sinal, seguindo o raciocínio de Jung e Cassirer. Para favorecer a construção desta reflexão apresentamos uma síntese da constituição da psique humana em seu formato individual e coletivo, conforme teoria desenvolvida por Jung. Por fim, analisamos resultados das projeções da sombra nas conformações de espacialidades religiosas, tomando como exemplo um recorte histórico da Fé Bahá'í.
Management of acquired haemophilia A
Authors: Scharf R. E. , Dobbelstein C. , Werwitzke S. , Tiede A.
Published: January 2015

Acquired haemophilia A (AHA) is caused by autoantibody inhibitors of coagulation factor VIII (FVIII : C). Recent onset of bleeds and isolated prolongation of the activated partial thromboplastin time (aPTT) are characteristic features of the disorder. Reduced FVIII : C activity and a detectable FVIII : C inhibitor in the Bethesda assay confirm the diagnosis. Patients should be referred to expert centres, whenever possible, and invasive procedures with a high risk of bleeding must be avoided, until haemostasis has been secured by adequate therapy.

Bypassing agents capable of inducing sufficient thrombin formation in the presence of FVIII : C inhibitors are treatment of choice, including currently available recombinant factor VIIa (NovoSeven™) and activated prothrombin complex concentrate (FEIBA™). These agents represent first line therapy to control acute or severe bleeds. To eradicate inhibitors, immunosuppressive treatment (IST) is indicated in patients with AHA. Glucocorticoids, cytotoxic agents and rituximab are most widely used. However, an ideal IST regimen has not been established so far. Adverse events of IST, including infections as the foremost cause death, are frequent complications in AHA.
Facing the Predicament of Wordlessness: When We Speak of Certain Musical Sounds
Authors: Qia Shen , Ingram Catherine
Published: January 2015

Over more than one hundred years, in the tide of “global westernization,” most of the Chinese words that were once used to describe musical sound have already been displaced by terminology based on that used in western music, especially western musical terminology of the Classical period. The words that were originally used in Chinese discourse—either within the history of literature or spread orally amongst folk musicians—have been lost or forgotten, and the system itself has already disintegrated and been pushed to the edge of today's mainstream discourse.
La videovigilancia laboral y el derecho a la protección de datos de carácter personal
Authors: Gude Fernández Ana
Published: January 2015

SUMMARY:1. THE NEW INSTRUMENTS OF CONTROL IN WORKPLACE: THE VIDEO CAMERAS.2. VIDEO SURVEILLANCE AND THE RIGHT TO THE PROTECTION OF INFORMATION OF PERSONAL CHARACTER.2.1. The right to the protection of information of personal character: differential characteristics opposite to the privacy right2.2. Images like information of personal character and its treatment2.3. Right to information and the assent of the worker affected by the video surveillance2.4. The principle of the quality of data. The prohibition of incompatible uses2.5. The principle of the security of data2.6. The Sentence 29/2013 of the Constitutional Court2.7. The cession of data2.8. The ARCO rights in the video surveillance in workplacesa. The right to accessb. The rights to rectification and cancellationc. Consequences of the infraction of the LOPD in this area3. CONCLUSIONSRESUMEN: Este trabajo tiene por objeto el examen de los problemas que plantea la videovigilancia laboral desde la perspectiva del derecho a la protección de los datos. La Ley Orgánica 5/1999, de 13 diciembre y su Reglamento de desarrollo son aplicables a las imágenes obtenidas por los empresarios a través de videocámaras de sus trabajadores; pues bien, el análisis de estos textos normativos así como de la jurisprudencia dictada sobre la materia, en especial la STC 29/2013 de 11 de febrero, constituyen el contenido principal de este estudio.ABSTRACT: This work focuses on workplace video surveillance and its implications from the viewpoint of the right to the protection of personal data. Organic Law 5/1999 and its development regulation applies to the images obtained by employers through use of video cameras. The analysis of these legal texts and of the jurisprudence, particularly of the Constitutional Court sentence of 11 February 2013, is the subject of this study.
Nueva Constitución y Asamblea Constituyente en Chile
Authors: Zúñiga Urbina Francisco
Published: January 2015

En este trabajo se aborda el debate abierto en Chile sobre la necesidad o no de convocar una Asamblea constituyente para elaborar una nueva Constitución. El autor sostiene que el debate no debería girar en torno a la asamblea constituyente, que es el medio o procedimiento; sino en el fin perseguido a propósito del problema y debate constituyentes: una nueva Constitución, fruto del poder constituyente democrático y sus contenidos normativos iusfundamentales abiertos al constitucionalismo moderno (liberal, democrático y social).This paper deals with the debate opened in Chile on the need or not to convene a constituent Assembly to elaborate the draft of a new Constitution. The author argues that the discussion should not revolve around the constituent Assembly, which is the means or process; but in the end pursued with regard to the problem and discussion: a new Constitution, result of the democratic constituent power and their normative contents open to the modern constitutionalism (liberal, democratic, and social).
Las referencias recíprocas entre el Tribunal Europeo y la Corte Interamericana de Derechos Humanos: ¿de la influencia al diálogo?
Authors: Groppi Tania , Lecis Cocco-Ortu Anna Maria
Published: January 2015

El artículo intenta aclarar los resultados de una investigación empírica sobre las referencias o citas recíprocas entre el Tribunal Europeo de Derechos Humanos (TEDH) y la Corte Interamericana de Derechos Humanos (Corte IDH), reconocibles en la motivación de sus resoluciones. Muchos estudios han destacado que el uso de precedentes extranjeros (o «extrasistémicos») no se limita a los Tribunales nacionales, sino afecta también a los Tribunales internacionales. Sin embargo, es frecuente un abuso de la apelación al «diálogo judicial» para estas prácticas: además, faltan datos empíricos completos y normalmente se encuentran algunos ejemplos bastante casuales.El artìculo presenta los resultados de una investigaciòn extensa y completa sobre las decisiones de los dos Tribunales en los años 1987-2012, para verificar si verdaderamente hay algún diálogo entre los dos sistemas. La investigaciòn sigue el metodo ya experimentado en estudios empíricos sobre el uso de precedentes extranjeros para los tribunales constitucionales, que está integrado al mismo tiempo para un análisis cuantitativo y cualitativo. La investigación no muestra evidencias de un verdadero diálogo entre las dos instituciones, sino de una convergencia jurisprudencial en varias materias.The article aims to analyze the mutual references made in their judgments by the European Court of Human Rights and the Inter-american Court of Human Rights.Previous studies on circulation of foreign precedents have been showing that the use of foreign or «extra-systemic» precedents is not a phenomenon limited to national courts, but does also affect international courts. Nontheless, the notion of «judicial dialogue» is often abused, and the interactions between courts are hardly proved through empirical data but rather through seldom examples.The article presents the results of a general and systemic research on the case-law of the two courts in the period between 1987 and 2012, to verify if there is some kind of «judicial dialogue» or «cross-fertilization» between the two systems. The research follows the methodology previously applied in empirical studies on the use of foreign precedents by constitutional courts, which consists of both a quantitative and a qualitative analysis.The research did not show any evidence of the existence of a real «dialogue» between the two courts, but rather of a «convergence» among their jurisprudence in several fields.
Efecto pantalla y efecto Sísifo: dos fenómenos didácticos en la resolución de problemas por transferencia analógica
Authors: Gómez-Ferragud Carlos Bernardo , Solaz-Portolés Joan Josep , Sanjosé López Vicente
Published: January 2015

Se presenta un estudio cualitativo, basado en entrevistas semi-estructuradas, de 2 casos que muestran dos fenómenos didácticos de interés en la resolución de problemas por transferencia analógica. El primero muestra un ‘efecto pantalla’, en el cual el sujeto no puede acceder a la estructura de los problemas a partir de los enunciados. En el segundo caso, el sujeto no logra alcanzar un estado estable de comprensión, a pesar de su avance, y por tanto acaba por retroceder a un estado de ausencia de conflicto cognitivo, pero indeseado desde el punto de vista didáctico (‘efecto Sísifo’). Se discuten las posibles implicaciones didácticas de estos casos.
La responsabilidad en la participación: un valor cooperativo en la educación primaria
Authors: Giné Sebastià , Grau Víctor , Piñana Marcel·lí , Suñé Morales Jordi
Published: January 2015

El artículo pretende destacar los principios del movimiento cooperativo, sus valores formativos y su necesaria vigencia en la actualidad. Se apuesta por el fomento de la responsabilidad en la participación en los diferentes cursos de educación primaria a partir del despliegue de diversos ejes de trabajo. Se ofrece una propuesta teoricopráctica de intervención tomando la escuela como principal ámbito de actuación concretada en diversas actividades a desarrollar en cada uno de los ciclos de una escuela de Tarragona. Los resultados de la investigación nos han puesto de manifiesto el interés, la reflexión y la sensibilidad del alumnado en temas relacionados con la responsabilidad en la participación, lo que nos insta a proseguir con optimismo para afrontar propuestas futuras.
Métodos cualitativos para la investigación en Didáctica de las Ciencias Sociales con alumnos en riesgo de exclusión social
Authors: Campo País Benito
Published: January 2015

la investigación educativa tiene que afrontar las problemáticas que existen en los diversos ámbitos educativos. En el complejo espacio de la reeducación de menores se observa que a las dificultades propias de su alumnado se une la necesidad de adaptar estrategias que mejoren y evalúen su aprendizaje. Conocer diseños de investigación innovadores en este contexto puede interesar tanto a los docentes en sus tareas de enseñanza con este tipo de alumnos, como a la metodología de investigación de la Didáctica de las Ciencias Sociales. Con tal motivo presentamos los métodos cualitativos utilizados en una investigación con alumnos en riesgo de exclusión donde se analiza la evolución en la adquisición de valores y competencias.
Análisis psicométrico de una escala de percepción sobre la utilidad de Moodle en la universidad
Authors: Olmos-Migueláñez Susana , Martínez-Abad Fernando , Torrecilla-Sánchez Eva María , Mena-Marcos Juanjo
Published: January 2015

Dada la importancia que los entornos virtuales de aprendizaje (learning management systems) han adquirido en la educación superior, y la generalización en el empleo de la plataforma Moodle en muchas instituciones universitarias, se diseña y se validan las cualidades psicométricas de una escala de utilidad percibida sobre el uso de Moodle. Se pretende aportar un instrumento válido y fiable que permita comprobar cuál es la percepción de los estudiantes sobre la utilidad de Moodle. De la población de estudiantes universitarios del ámbito de las Ciencias de la Educación, se obtiene una muestra de 754 sujetos. Los resultados manifiestan que la escala evalúa, adecuadamente, la utilidad de la plataforma en cinco dimensiones: contenidos, actividades, evaluación, interacción y aprendizaje. Finalmente, se discute sobre la utilidad de la escala para evaluar la utilidad de Moodle y para la implementación de procesos de mejora de su empleo en las instituciones de Educación Superior.
RELIEVE: veinte años inmersos en la cronología del acceso abierto a la ciencia
Authors: Melero Remedios
Published: January 2015

Coincidiendo con los 20 primeros años de RELIEVE, se presenta un análisis comparativo de los principales hitos históricos de la revista y los del movimiento de Acceso Abierto en todo el mundo, a fin de enmarcar mejor su evolución. Se revisan algunas de las principales aportaciones que se han vivido en estas dos décadas en el campo de la comunicación científica: aparición y desarrollo de revistas electrónicas, desarrollo del movimiento del Acceso Abierto, aparición de repositorios, desarrollo de plataformas de gestión de artículos, nuevas bases de datos, etc.
Las revistas mexicanas de investigación educativa rumbo a la corriente principal de difusión de la ciencia
Authors: Cabrera-Flores Mayer , Luna Edna , Vidauri Gabriela
Published: January 2015

El propósito de este estudio es analizar el caso de la Revista Electrónica de Investigación Educativa (REDIE)  en su trayecto rumbo a la corriente principal de difusión científica. Para ello, presenta la evolución de la política mexicana sobre las revistas, la situación de las revistas mexicanas de investigación educativa, y profundiza sobre la REDIE. En esta evolución se identificaron tres momentos: estandarización de los criterios de calidad, digitalización y acceso abierto de las revistas científicas, en los que confluyen instancias como REDALYC y LATINDEX y las iniciativas individuales de revistas que impulsan el desarrollo de la difusión científica del país. Se concluye sobre la necesidad de lograr la  coincidencia en los esfuerzos de los diversos actores: organismos gubernamentales, instituciones y comunidades académicas.
Potassium dependent rescue of a myopathy with core-like structures in mouse
Authors: Hanson M Gartz , Wilde Jonathan J , Moreno Rosa L , Minic Angela D , Niswander Lee
Published: January 2015

Myopathies decrease muscle functionality. Mutations in ryanodine receptor 1 (RyR1) are often associated with myopathies with microscopic core-like structures in the muscle fiber. In this study, we identify a mouse RyR1 model in which heterozygous animals display clinical and pathological hallmarks of myopathy with core-like structures. The RyR1 mutation decreases sensitivity to activated calcium release and myoplasmic calcium levels, subsequently affecting mitochondrial calcium and ATP production. Mutant muscle shows a persistent potassium leak and disrupted expression of regulators of potassium homeostasis. Inhibition of KATP channels or increasing interstitial potassium by diet or FDA-approved drugs can reverse the muscle weakness, fatigue-like physiology and pathology. We identify regulators of potassium homeostasis as biomarkers of disease that may reveal therapeutic targets in human patients with myopathy of central core disease (CCD). Altogether, our results suggest that amelioration of potassium leaks through potassium homeostasis mechanisms may minimize muscle damage of myopathies due to certain RyR1 mutations.
Non‐Volatile Analog Control and Reconfiguration of a Vortex Nano‐Oscillator Frequency
Authors: Stebliy Maksim , Jenkins Alex , Benetti Luana , Paz Elvira , Ferreira Ricardo
Published: August 2024

Magnetic tunnel junctions are nanoscale devices that have recently attracted interest in the context of frequency multiplexed spintronic neural networks, due to their interesting dynamical properties, which are defined during the fabrication process, and depend on the material parameters and geometry. This work proposes an approach to extending the functionality of a standard magnetic tunnel junction (MTJ) by introducing an additional ferromagnet/antiferromagnet (FM/AFM) storage layer (SL) vertically integrated with the standard vortex MTJ stack into the nanopillar. The magnetostatic field created by this storage layer acts on the free layer and can be used to change its static and dynamic properties. To tune the magnitude and direction of this magnetostatic field, magnetic reconfiguration is carried out through a thermally assisted switching mechanism using a voltage pulse that heats the AFM layer in the SL above the Néel temperature in the presence of an external field. It is experimentally shown that using an MTJ based on a 600 nm diameter nanopillar with a vortex in the free layer, reconfiguration of the SL allows to continuously change the core precession frequency in the 15 MHz range, or ≈10% of the device frequency.
Aerogel Fibers Made via Generic Sol‐Gel Centrifugal Spinning Strategy Enable Dynamic Removal of Volatile Organic Compounds From High‐Flux Gas
Authors: Wen Zhu , Lyu Jing , Ding Yafei , Liu Bin , Zhang Xuetong
Published: August 2024

Aerogels with ultrahigh porosity and large specific surface area have demonstrated great potential for capturing volatile organic compounds (VOCs). Especially, aerogel fiber aggregates with macropores formed by overlapping aerogel fibers and mesopores in the aerogel fibers might realize fast sorption kinetics and high sorption capacity simultaneously. However, how to develop fast fabrication and large‐scale production of aerogel fibers remains a challenge. Herein, a generic sol‐gel centrifugal spinning (SCS) strategy with a spinning rate capable of reaching 700 m min−1 is developed for producing aerogel fibers. The representative SCS aerogel fiber made from aramid nanofiber (ANF) dispersion exhibits a large specific surface area (313 m2 g−1) and high tensile strength (12.48 MPa). The SCS strategy is further applied to fabricate various kinds of aerogel fibers, including sodium alginate, cellulose, and chitosan. The ANF aerogel fiber aggregates exhibit superior VOC adsorption capacity of 438.0 mg g−1 under an ultrafast gas flux of 3.8 × 104 L m−2 h−1, which also has satisfactory cyclic stability. This work not only develops a powerful and generic strategy for fabricating aerogel fibers in large scale, but also provides inspiration for applying these SCS aerogel fibers in dynamic removal of VOCs and other environmental protection fields.
Chimie Douce Derived Novel P2‐Type Layered Oxide for Potassium‐Ion Batteries
Authors: Jha Pawan Kumar , Golubnichiy Alexander , Sachdeva Dorothy , Banerjee Abhik , Sai Gautam Gopalakrishnan , Fichtner Maximilian , Abakumov Artem M. , Barpanda Prabeer
Published: August 2024

The emergence of K‐ion batteries (KIBs) heralds a promising frontier in energy storage technology, offering the potential for high specific energy density, long cycle life, and robust power capabilities, all while utilizing the abundant resources of potassium. In response to the challenges posed by synthetic intricacies related to K‐based cathodes, the effort is directed toward employing soft chemistry (chimie douce) method to unveil a hitherto‐unknown P2‐type K1/3Co1/3Mn2/3O2 (KCM) layered oxide cathode for KIBs. Comprehensive analysis using diffraction, microscopy, and spectroscopy tools reveals the ion exchange reaction proceeds through overlay ordered structure formation mechanism. The as‐prepared KCM material serves as a ≈2.9 V positive K+ insertion host. Further, it showcases an exceptional structural reversibility, robust cycling performance with ≈100% coulombic efficiency even after 100 cycles, and maintaining electrochemical stability even at elevated temperature (c.a. 40° and 50 °C). The KCM cathode exhibits in‐plane Co–Mn ordering and solid‐solution redox mechanism during (de)potassiation. Combining first‐principles calculations with experimental tools, this research demonstrates the efficacy of ambient ion‐exchange route in stabilizing promising cathode materials for KIBs. This innovative synthetic approach not only streamlines synthetic complexities, but also holds significant implications for the advancement of KIB technology for stationary energy storage.
Ru Doped Ir Nanowires for High‐Efficient and Durable Proton Exchange Membrane Water Electrolyzers
Authors: Pang Bingqian , Feng Suyang , Xu Yueshan , Chen Hui , Li Jing , Yuan Yuliang , Zou Xiaoxin , Tian Xinlong , Kang Zhenye
Published: August 2024

Long‐term operation of proton exchange membrane water electrolysis (PEMWE) poses significant challenges due to the high potential and strong acidic environment associated with the oxygen evolution reaction (OER), leading to severe catalyst degradation. Here, ultrafine iridium–ruthenium nanowires (IrRu NWs) are developed through a facile process, which exhibits excellent activity and stability for acidic OER. The IrRu NWs achieve an overpotential of 243 mV at 10 mA cm−2, which is significantly lower than that of commercial IrO2 and pure Ir nanowires. Importantly, the IrRu NWs demonstrate 17.6% higher current density at 2 V in real PEMWE device than that of the commercial IrO2 and Pt/C catalysts at the anode and cathode, respectively. The PEMWE device with the IrRu NWs catalyst layers can be stably operated at 1.0 and 1.5 A cm−2 for more than 500 h with a degradation rate of only 28 µV h−1, which makes the IrRu NWs a promising catalyst toward PEMWE applications.
Exciton Dissociation and Recombination Afford Narrowband Organic Afterglow Through Efficient FRET
Authors: Zhang Jingyu , Wang Wuji , Bian Yanfang , Wang Yike , Lu Xinchi , Guo Zhenli , Sun Chengxi , Li Zecai , Zhang Xiao , Yuan Jie , Tao Ye , Huang Wei , Chen Runfeng
Published: August 2024

Organic afterglow with long‐persistent luminescence (LPL) after photoexcitation is highly attractive, but the realization of narrowband afterglow with small full‐width at half‐maximum (FWHM) is a huge challenge since it is intrinsically contradictory to the triplet‐ and solid‐state emission nature of organic afterglow. Here, narrow‐band, long‐lived, and full‐color organic LPL is realized by isolating multi‐resonant thermally activated delayed fluorescent (MR‐TADF) fluorophores in a glassy steroid‐type host through a facile melt‐cooling treatment. Such prepared host becomes capable of exciton dissociation and recombination (EDR) upon photoirradiation for both long‐lived fluorescence and phosphorescence; and, the efficient Förster resonance energy transfer (FRET) from the host to various MR‐TADF emitters leads to high‐performance LPL, exhibiting small FWHM of 33 nm, long persistent time over 10 s, and facile color‐tuning in a wide range from deep‐blue to orange (414–600 nm). Moreover, with the extraordinary narrowband LPL and easy processability of the material, centimeter‐scale flexible optical waveguide fibers and integrated FWHM/color/lifetime‐resolved multilevel encryption/decryption devices have been designed and fabricated. This novel EDR and singlet/triplet‐to‐singlet FRET strategy to achieve excellent LPL performances illustrates a promising way for constructing flexible organic afterglow with easy preparation methods, shedding valuable scientific insights into the design of narrow‐band emission in organic afterglow.
Harnessing and Mimicking Bacterial Features to Combat Cancer: From Living Entities to Artificial Mimicking Systems
Authors: Gao Peng , Duan Zhenyu , Xu Gang , Gong Qiyong , Wang Jing , Luo Kui , Chen Jie
Published: August 2024

Bacterial‐derived micro‐/nanomedicine has garnered considerable attention in anticancer therapy, owing to the unique natural features of bacteria, including specific targeting ability, immunogenic benefits, physicochemical modifiability, and biotechnological editability. Besides, bacterial components have also been explored as promising drug delivery vehicles. Harnessing these bacterial features, cutting‐edge physicochemical and biotechnologies have been applied to attenuated tumor‐targeting bacteria with unique properties or functions for potent and effective cancer treatment, including strategies of gene‐editing and genetic circuits. Further, the advent of bacteria‐inspired micro‐/nanorobots and mimicking artificial systems has furnished fresh perspectives for formulating strategies for developing highly efficient drug delivery systems. Focusing on the unique natural features and advantages of bacteria, this review delves into advances in bacteria‐derived drug delivery systems for anticancer treatment in recent years, which has experienced a process from living entities to artificial mimicking systems. Meanwhile, a summary of relative clinical trials is provided and primary challenges impeding their clinical application are discussed. Furthermore, future directions are suggested for bacteria‐derived systems to combat cancer.
Ultra‐Weak Polarization‐Strain Coupling Effect Boosts Capacitive Energy Storage
Authors: Zhang Leiyang , Jing Ruiyi , Huang Yunyao , Yang Yule , Li Yang , Tang Mingyang , Cao Shuyao , Chen Zibin , Gao Feng , Du Yuxiao , Zhou Shiyu , Zhao Jianwei , Liu Shiyu , Wang Dawei , Zhang Shujun , Jin Li
Published: August 2024

In pulse power systems, multilayer ceramic capacitors (MLCCs) encounter significant challenges due to the heightened loading electric field (E), which can lead to fatigue damage and ultrasonic concussion caused by electrostrictive strain. To address these issues, an innovative strategy focused on achieving an ultra‐weak polarization‐strain coupling effect is proposed, which effectively reduces strain in MLCCs. Remarkably, an ultra‐low electrostrictive coefficient (Q33) of 0.012 m4 C−2 is achieved in the composition 0.55(Bi0.5Na0.5)TiO3‐0.45Pb(Mg1/3Nb2/3)O3, resulting in a significantly reduced strain of 0.118% at 330 kV cm−1. At the atomic scale, the local structural heterogeneity leads to an expanded and loose lattice structure, providing ample space for large ionic displacement polarization instead of lattice stretching when subjected to the applied E. This unique behavior not only promotes energy storage performance (ESP) but also accounts for the observed ultra‐low Q33 and strain. Consequently, the MLCC device exhibits an impressive energy storage density of 14.6 J cm−3 and an ultrahigh efficiency of 93% at 720 kV cm−1. Furthermore, the superior ESP of the MLCC demonstrates excellent fatigue resistance and temperature stability, making it a promising solution for practical applications. Overall, this pivotal strategy offers a cost‐effective solution for state‐of‐the‐art MLCCs with ultra‐low strain‐vibration in pulse power systems.
Tuning the 5d State of Pr3+ in Oxyhalides for Efficient Deep Ultraviolet Upconversion
Authors: Du Yangyang , Jin Zhengyuan , Li Ziyu , Sun Tianying , Meng Haotian , Jiang Xiaojuan , Wang Yu , Peng Dengfeng , Li Jianwei , Wang Aiwu , Zou Hua , Rao Feng , Wang Feng , Chen Xian
Published: August 2024

Visible‐to‐ultraviolet (UV) upconversion provides a fascinating strategy to achieve deep UV emission through readily accessible visible light. However, the intensity of deep UV emission obtained through visible‐to‐UV upconversion progress is still far from satisfactory, severely constraining its practical applications. Herein, a novel class of praseodymium ion (Pr3+)‐doped rare‐earth oxyhalides (YOCl, YOBr, and LuOBr) to achieve efficient upconverted deep UV emission in the spectral range of 250–350 nm is developed. The upconverted UV emission intensity of LuOBr:Pr3+ is determined to be 56.7 times stronger than that of the well‐established Lu7O6F9:Pr3+. When employed as a photon‐converter to activate photocatalytic water splitting reactions, upconverted deep UV emission enables H2 generation under visible light (λ > 420 nm) excitation from a xenon lamp. The efficient deep UV upconversion stems from tuning 4f15d1 state of Pr3+ by oxyhalide constituent which both facilitates the absorption of excitation photons in long‐lived intermediate 4f2 states and suppress the probability of nonradiative relaxation from 4f15d1 state. These findings not only provide new insights into a mechanistic understanding of the host effect on upconversion process but also make a breakthrough in developing efficient deep upconversion materials that will expand their further applications.
Broadband Near‐Infrared Cr4+‐Doped Garnet Phosphors through Divalent Calcium Charge Compensation for Advanced Crystal Fiber Amplifiers
Authors: Hsiao Yu‐Hsuan , Chen Kuan‐Chun , Chien Chun‐Ling , Huang Wen‐Tse , Majewska Natalia , Kamiński Mikołaj , Mahlik Sebastian , Leniec Grzegorz , Mijowska Ewa , Huang Sheng‐Lung , Liu Ru‐Shi
Published: August 2024

Near‐infrared‐II (NIR‐II) phosphors are extensively used as NIR phosphor‐converted light‐emitting diodes across various applications. Nonetheless, their application in fiber communication remains underexplored. Furthermore, efficiency challenges persist in developing broadband NIR crystal fiber amplifiers. A series of the Y3−yAl5−xO12:xCr,yCa2+ phosphors with boosted Cr4+ concentration via calcium charge compensation is synthesized, and the optimized sample is fabricated to crystal fibers to reveal the application of the NIR‐II phosphors to fiber communication. The fabricated Cr4+‐doped crystal fiber, exhibiting broadband Cr4+ emission within 1100–1600 nm, effectively covers the high‐transmission loss region caused by water absorption in the telecommunication band. Comprehensive characterization and analyses of the Cr4+ are discussed. Y2.84Al4.9O12:0.1Cr,0.16Ca2+ crystal fiber, fabricated through phosphor synthesis, pellets’ production, and the laser‐heated pedestal growth method, exhibits superior photoluminescence compared to the commercial Cr4+‐doped Y3Al5O12 crystal fiber. Here the potential of NIR‐II phosphors is highlighted in enhancing fiber communication and valuable insights for their future application are provided.
Detection of Foodborne Pathogens Through Volatile Organic Compounds Sensing via Metal Oxide Gas Sensors
Authors: Lawaniya Shiv Dutta , Awasthi Anjali , Menezes Prashanth W. , Awasthi Kamlendra
Published: August 2024

Foodborne pathogens are a crucial diagnostic target for the food, beverage, and healthcare sectors due to their ubiquity and the potential damage they may do to the public's well‐being, food safety, and the economy. Over the past few decades, there has been an increased focus on developing highly precise and trusted biosensors in an effort to eliminate the discrepancy between reporting demands and currently used traditional detection approaches. Metal oxide semiconductor (MOS)‐based gas sensors have rapidly advanced in recent years, becoming a dominating technology for developing devices in food‐quality management, biomedical research, and diagnostics. This review systematically explores recent advancements in gas sensing technologies utilizing metal oxide‐based sensors for the detection of foodborne pathogens through the analysis of volatile organic compounds (VOCs). The comprehensive discussion encompasses insights into various foodborne pathogens, their implications for human health, diverse metal oxide characteristics, strategies for enhancing their sensing capabilities, and the distinctive features of VOCs. Furthermore, a thorough examination of the utilization of different metal oxides in VOC sensing is provided, addressing both existing challenges and potential future developments. In summary, employing gas sensing techniques for foodborne pathogen detection holds substantial commercial promise compared to alternative bio‐sensing approaches.
Endothelial Cells Mediated by STING Regulate Oligodendrogenesis and Myelination During Brain Development
Authors: Wang Wenwen , Wang Yanyan , Su Libo , Zhang Mengtian , Zhang Tianyu , Zhao Jinyue , Ma Hongyan , Zhang Dongming , Ji Fen , Jiao Ryan Dingli , Li Hong , Xu Yuming , Chen Lei , Jiao Jianwei
Published: August 2024

Oligodendrocyte precursor cells (OPCs) migrate extensively using blood vessels as physical scaffolds in the developing central nervous system. Although the association of OPCs with the vasculature is critical for migration, the regulatory mechanisms important for OPCs proliferative and oligodendrocyte development are unknown. Here, a correlation is demonstrated between the developing vasculature and OPCs response during brain development. Deletion of endothelial stimulator of interferon genes (STING) disrupts angiogenesis by inhibiting farnesyl‐diphosphate farnesyltransferase 1 (FDFT1) and thereby reducing cholesterol synthesis. Furthermore, the perturbation of metabolic homeostasis in endothelial cells increases interleukin 17D production which mediates the signal transduction from endothelial cells to OPCs, which inhibits oligodendrocyte development and myelination and causes behavioral abnormalities in adult mice. Overall, these findings indicate how the endothelial STING maintains metabolic homeostasis and contributes to oligodendrocyte precursor cells response in the developing neocortex.
Dissecting the Distinct Tumor Microenvironments of HRD and HRP Ovarian Cancer: Implications for Targeted Therapies to Overcome PARPi Resistance in HRD Tumors and Refractoriness in HRP Tumors
Authors: Qiu Junjun , Ren Tingting , Liu Qinqin , Jiang Qian , Wu Tong , Cheng Leong Chi , Yan Wenqing , Qu Xinyu , Han Xiao , Hua Keqin
Published: August 2024

High‐grade serous tubo‐ovarian cancer (HGSTOC) is an aggressive gynecological malignancy including homologous recombination deficient (HRD) and homologous recombination proficient (HRP) groups. Despite the therapeutic potential of poly (ADP‐ribose) polymerase inhibitors (PARPis) and anti‐PDCD1 antibodies, acquired resistance in HRD and suboptimal response in HRP patients necessitate more precise treatment. Herein, single‐cell RNA and single‐cell T‐cell receptor sequencing on 5 HRD and 3 HRP tumors are performed to decipher the heterogeneous tumor immune microenvironment (TIME), along with multiplex immunohistochemistry staining and animal experiments for validation. HRD tumors are enriched with immunogenic epithelial cells, FGFR1+PDGFRβ+ myCAFs, M1 macrophages, tumor reactive CD8+/CD4+ Tregs, whereas HRP tumors are enriched with HDAC1‐expressing epithelial cells, indolent CAFs, M2 macrophages, and bystander CD4+/CD8+ T cells. Significantly, customized therapies are proposed. For HRD patients, targeting FGFR1+PDGFRβ+ myCAFs via tyrosine kinase inhibitors, targeting Tregs via anti‐CCR8 antibodies/TNFRSF4 stimulation, and targeting CXCL13+ exhausted T cells by blocking PDCD1/CTLA‐4/LAG‐3/TIGIT are proposed. For HRP patients, targeting indolent CAFs, targeting M2 macrophages via CSF‐1/CSF‐1R inhibitors, targeting bystander T cells via tumor vaccines, and targeting epithelial cells via HDAC inhibitors. The study provides comprehensive insights into HRD and HRP TIME and tailored therapeutic approaches, addressing the challenges of PARPi‐resistant HRD and refractory HRP tumors.
CDK4/6 Inhibitors Impede Chemoresistance and Inhibit Tumor Growth of Small Cell Lung Cancer
Authors: Wen Yang , Sun Xue , Zeng Lingge , Liang Shumei , Li Deyu , Chen Xiangtian , Zeng Fanrui , Zhang Chao , Wang Qiongyao , Zhong Qinsong , Deng Ling , Guo Linlang
Published: August 2024

Small cell lung cancer (SCLC) is characterized by rapid development of chemoresistance and poor outcomes. Cyclin‐dependent kinase 4/6 inhibitors (CDK4/6is) are widely used in breast cancer and other cancer types. However, the molecular mechanisms of CDK4/6 in SCLC chemoresistance remain poorly understood. Here, Rb1flox/flox, Trp53flox/flox, Ptenflox/flox (RTP) and Rb1flox/flox, Trp53flox/flox, MycLSL/LSL (RPM) spontaneous SCLC mouse models, SCLC cell line‐derived xenograft (CDX) models, and SCLC patient‐derived xenograft (PDX) models are established to reveal the potential effects of CDK4/6is on SCLC chemoresistance. In this study, it is found that CDK4/6is palbociclib (PD) or ribociclib (LEE) combined with chemotherapeutic drugs significantly inhibit SCLC tumor growth. Mechanistically, CDK4/6is do not function through the classic Retionblastoma1 (RB) dependent axis in SCLC. CDK4/6is induce impair autophagy through the AMBRA1‐lysosome signaling pathway. The upregulated AMBRA1 protein expression leads to CDK6 degradation via autophagy,  and the following TFEB and TFE3 nuclear translocation inhibition leading to the lysosome‐related genes levels downregulation. Moreover, it is found that the expression of CDK6 is higher in SCLC tumors than in normal tissue and it is associated with the survival and prognosis of SCLC patients. Finally, these findings demonstrate that combining CDK4/6is with chemotherapy treatment may serve as a potential therapeutic option for SCLC patients.