bluuebunny/crossref_metadata_2025 huggingface dataset:
Aktivitas Antifungi Ekstrak Metanol Sarcotheca diversifolia (Miq) Hallier F terhadap Pertumbuhan Candida albicans
Authors: Yuliati  , Kurniatuhadi Rikhsan , Khotimah Siti
Published: October 2024

Asam Kalimbawan (Sarcotheca diversifolia (Miq) Hallier F.) merupakan tumbuhan liar yang berpotensi sebagai tanaman obat dan diketahui  sebagai antioksidan. Tujuan penelitian ini untuk mengetahui potensi antifungi ekstrak metanol buah Sarcotheca diversifolia terhadap Candida albicans. Ekstraksi buah asam kalimbawan (S. diversifolia) dilakukan dengan metode maserasi pada pelarut metanol pro analis. Pengujian antifungi menggunakan metode difusi lubang sumuran di media Saboraud Dextrose Agar. Konsentrasi ekstrak metanol buah S. diversifolia yang diujikan adalah 0,2; 0,4; 0,6; dan 0,8 g/ml, kontrol positif ketokonazol 2%, dan kontrol negatif DMSO 10%. Hasil penelitian memperlihatkan bahwa ekstrak metanol buah asam kalimbawan (S. divesifolia) dapat menghambat pertumbuhan C. albicans melalui pembentukan zona bening di sekitar sumuran. Daya hambat ekstrak metanol buah asam kalimbawan pada ketiga konsentrasi termasuk dalam kategori sedang dengan sifat daya hambat fungistatik. Kekuatan daya hambat dari ekstrak metanol buah asam kalimbawan tersebut memiliki 29-28% dibandingkan dengan daya hambat 2% ketokonazol dengan kategori kuat. Semua konsentrasi uji bersifat fungistatik di jam ke 48. Metabolit sekunder yang terdeteksi pada ekstrak metanol buah S. diversifolia terdiri atas alkaloid, flavonoid, steroid, terpenoid, saponin, dan tanin. Buah asam kalimbawan (S. divesifolia) diduga berpotensi sebagai fungistatik berbasis bahan alam.
Comparative Analysis of Mitragynine Content in Kratom Leaves (Mitragyna speciosa Korth) from Kabupaten Kapuas Hulu Using HPLC Method
Authors: Novianry Virhan , Astuti Puji , Andriani
Published: October 2024

Opioid drugs are common analgesics for managing chronic pain, but they have significant short- and long-term side effects. Despite this, opioid consumption continues to rise in high-income countries, raising concerns about dependency. Kratom (Mitragyna speciosa Korth), which has opioid-like effects, shows potential as an analgesic with fewer side effects. This study aimed to explore and compare the mitragynine content in Kratom leaves from various regions in Kabupaten Kapuas Hulu, Indonesia, using High-Performance Liquid Chromatography (HPLC). Kratom leaves from 14 regions in Kapuas Hulu were collected, dried, and ground. Mitragynine was extracted using 70% ethanol and analyzed with HPLC. The yield percentage and mitragynine content in both the powdered simplisia and ethanol extract were measured and compared. The study showed that the average ethanol extract yield was 28%, with the highest yield from Elis Menendang (31.20%) and the lowest from Nanga Lauk (23.86%). Mitragynine content was significantly higher in the ethanol extract (3.22%) compared to the powdered simplisia (1.46%). Samples from Lanjak, Jongkong, Bunut, and Putussibau Kota showed mitragynine content exceeding 4% in the ethanol extract. HPLC analysis indicated that ethanol extraction significantly increases the mitragynine content in Kratom leaves compared to powdered simplisia, up to twice as much.
SPEAKING TO THE SOUL THROUGH THE HEART: A PHILOSOPHICAL APPROACH TO SWAHILI POETRY
Authors:   Department of Kiswahili and Other African Languages Maseno University P.O 333, Maseno - Kenya., Ngesa Indede Florence
Published: October 2024

In poetry, culture and history, the concept of the heart, the soul and the mind play a pivotal place in the body of the human being. RenÃ© Descartes (1596-1650) philosophy, cogito, ergo sum is noted by philosophers as the first principle of his theory of knowledge and concept of self. As illustrated by researchers who employed Descartes philosophical thinking, the heart has its reasons, which reason does not know. The heart is considered as the source of emotions, passion and wisdom. It is the center of action. The soul, heart, mind and spirit are correlated or rather coordinated with the physical body. All these arguments complement the dualism philosophy of Descartes theory. This paper investigates the concepts of self-identity, self- consciousness, self-discovery, and self assurance as presented in two Swahili Poetry: Al-Inkishafi by Said Abdalla bin Ali bin Nassir (1720-1820) and Moyo Iwa na Subira by Abdilatif Abdalla (1973). The interwoven poetic artistic device of the soul-heart, mind and body connect the poets with their holistic being in a self-examination, evaluation, revelation and assurance amid the environmental and social challenges of their time.
NEONATAL ADRENAL HEMORRHAGE
Authors:   Faculty of Medicine and Pharmacy, Moulay Abdellah University, Fez, Morocco., Rahmouni S. , Skalli Houssaini K. ,   Department of Neonatology and Neonatal Resuscitation Unit, University Hospital Hassan II, Fes, Morocco., D. Oukachou El. ,   Department of Neonatology and Neonatal Resuscitation Unit, University Hospital Hassan II, Fes, Morocco., Ouanouche El. ,   Higher Institute of Nursing and Health Technology of Tanger- Morocco.,   Biology and Health Department. Faculty of Science. Ibn Tofail University Kenitra-Morocco., Stati S. ,   Psychiatric Emergency Department, Arrazi Psychiatric University Hospital, Sale Morocco., Hmami F. ,   Faculty of Medicine and Pharmacy, Moulay Abdellah University, Fez, Morocco.,   Department of Neonatology and Neonatal Resuscitation Unit, University Hospital Hassan II, Fes, Morocco.
Published: October 2024

Introduction: Adrenal hemorrhage is a rare condition in the neonatal period. The significant size of the adrenal gland and its particular hypervascularization are predisposing factors for bleeding, especially in cases of trauma or vascular thrombosis (of the renal vessels or the inferior vena cava). The aim of this study is to analyze the medical records to perform a descriptive study of neonates hospitalized in the Neonatology and Neonatal Resuscitation Department of CHU Hassan II in Fez. Method:The cross-sectional study included all cases of neonates diagnosed with adrenal hemorrhage based on renal ultrasounds performed at the Neonatology and Neonatal Resuscitation Department of CHU Hassan II in Fez, between January 2016 and December 2023. Result: Sixteen cases of adrenal hemorrhage were identified. The incidence of adrenal hemorrhage during the study period within the department was 2 per 1,000 hospitalizations. Both sexes are equally affected, with a male predominance of 62.5%. The two main reasons for hospitalization in our series were perinatal asphyxia and jaundice. Uterine expression was reported in 87.5% of cases. The most common clinical signs, in order of frequency, are: jaundice (56.25%), abdominal mass (50%), skin and mucous membrane pallor (31.25%), fever (31.25%), respiratory distress (31.25%), and fractures in 6.25% of cases. Severe hyperbilirubinemia was found in 3 patients, accounting for 18.75%. Anemia was found in 6 patients, or 37.5%. Adrenal insufficiency was observed in 3 cases, or 18.75%. Abdominal ultrasound was performed on all patients, revealing right adrenal hemorrhage in 8 cases, left in 5 cases, and bilateral in 3 cases. The outcome was favorable in 81.25% of cases, while 18.75% of patients died. Conclusion: Adrenal hematoma is a rare condition in the neonatal period but can be severe, which justifies systematically searching for it in the presence of risk factors. Abdominal ultrasound is the key diagnostic test. The condition typically resolves spontaneously after several weeks.
FUSING FAITH AND FINANCE VIA FATWA: THE FUTURE OF WAQF-TAKAFUL DEATH COMPENSATION PRODUCT AT FWD TAKAFUL BERHAD
Authors:   Senior Lecturer, Academy of Contemporary Islamic Studies (ACIS), UniversitiTeknologi MARA (UiTM), 02600, Arau, Perlis, Malaysia., Abu Bakar Marina , Ismail Sukriah ,   Lecturer, Kulliyyah of Shariah & Law, Universiti Islam Antarabangsa Sultan Abdul Halim Muadzam Shah (UniSHAMS), 09300, Kuala Ketil, Kedah, Malaysia., Shaker Hussain Hanizan ,   Senior Lecturer, School of Computing, Quest International University, Perak, Malaysia., Saufee Anuar Mohamad ,   Assistant Manager, Corporate Communication, Ranhill SAJ Sdn. Bhd, Johor, Malaysia., Nasri Ali Md ,   Agency Manager, Takaful Ikhlas Family Berhad, Pulau Pinang, Malaysia.
Published: October 2024

The waqf-takaful concept involves channeling death compensation benefits from deceased takaful participants to selected religious institutions, thereby generating perpetual and sustainable waqf contributions. Despite recent challenges such as inconsistent implementation standards and management issues, some takaful operators in Malaysia have started to incorporate death compensation waqf into their offerings. Key players in this field, such as FWD Takaful Berhad, Waqaf An-Nur Corporation Berhad (WanCorp) and Yayasan Waqaf Malaysia (YWM), have significant potential for collaboration in advancing this product. This study aims to develop a waqf-takaful death compensation product for FWD Takaful Berhad, known as FATWA. This product integrates elements of death compensation waqf and takaful, combining the efforts of FWD Takaful with WanCorp and YWM to optimize takaful benefits. The study uses a qualitative approach, with data collected through focus group discussions involving academics in Islamic finance, waqf, law and marketing, as well as industry players from selected takaful companies in Malaysia, YWM and the Malaysian Takaful Association (MTA). The data were analysed using thematic analysis via ATLAS.ti software. The study found that waqf-takaful death compensation products, FATWA developed by FWD Takaful Berhad through WanCorp or YWM, have unique strengths. Both are competitive and capable of making significant contributions to the takaful and waqf industries, offering substantial benefits to the Muslim community as a whole.
Latent Profile Analysis of Unmarried Men and Women According to the Views on Marriage and Childrearing in South Korea: A Study of the Influence of Individualism and Collectivism
Authors: Lee Soo-Min , Cho Sung-Bong
Published: October 2024

Objectives: This study aimed to classify latent profiles of unmarried adults based on their views on marriage and childrearing, explore the influence of cultural orientation on the profiles, and examine differences in marriage intention. Methods: Data were collected from 886 single men and women aged 25-40. Latent profile analysis was conducted separately for each sex. Results: First, both men and women were classified into three latent profiles. The male profiles were named “Affective/Traditional Family-Oriented” (17%), “Ambiguous-Neutral” (71%), and “Couple-Centered & Childrearing Avoidant” (12%). The female profiles were named “Traditional Family-Oriented” (11%), “Ambiguous-Neutral” (67%), and “Career/Self-Oriented & Childrearing Avoidant” (22%). Second, for men, subfactors of collectivism (advice and harmony) and a subfactor of individualism (responsibility) were associated with the profiles. For women, subfactors of collectivism (advice and harmony) were associated with the profiles. Third, there were significant differences in marriage intentions across profiles for both men and women. Conclusions: The results indicate that while men and women show overall similarities in the latent profile classifications of marriage and childrearing, there are notable differences as well. Detailed explanations of the findings are discussed.
Consensual Qualitative Research on the Experiences of Common Factors among Couple and Family Counseling Experts in Korea
Authors: Han Ji Soo , Choi Youn Shil , Park Jung Wan , Bae Mi Hyun , Lee Mi Young
Published: October 2024

Objectives: The purpose of this study is to explore the experiences of Korean couple and family counseling professionals regarding common factors, and to derive the common factors that they recognize. Methods: Consensual Qualitative Research (CQR) was applied to collect data through in-depth interviews with 10 couple and family counseling experts. Results: Eight areas and 31 sub-areas were derived. First, Korean couples and family counseling professionals' experiences on common factors were found through “the need for theory and counseling models”, “the need for an integrated approach”, and “recognition of common factors”. Second, the general common factors of couple and family counseling were “therapist factors”, “client factors”, “cooperative relationship factors”, and “therapeutic intervention factors”. Third, the specific common factors of couple and family counseling were “dealing with subsystems”, “changing perspectives on problems”, “breaking away from dysfunctional patterns”, “expanding into systemic change”, and “restructuring relationship experiences”. Conclusions: By deriving common factors in domestic couple and family counseling, we established an integrated understanding of the principles of therapeutic change and the basis for effective intervention.
Rigid body dynamics from the Euler equations to the spacecraft attitude control in the works of scientists from Saint Petersburg State University. Part 3
Authors:   St. Petersburg State University, Tikhonov Аlexey А.
Published: October 2024

This article is a continuation of the survey dedicated to the 300th anniversary of Saint Petersburg State University (SPbSU) and is an attempt to analyze the scientific achievements of the St.Petersburg School of Mechanics in the field of rigid body dynamics. This third part of the review is devoted to the 50-year period ending in 2023. It focuses on applied research carried out by scientists from St. Petersburg State University in the 1970s and devoted to the uncontrolled attitude motion of a rigid body in the gravitational and magnetic fields of the Earth. A significant place among these studies is occupied by the solution of problems related to the passive gravitational stabilization of artificial satellites using magnetic interaction to create restoring and damping torques.
Etiological structure, clinical and epidemiological characteristics of bloodstream infections caused by resistant microorganisms among COVID-19 patients
Authors:   St. Petersburg State University, Musatov Vladimir ,   Clinical Infectious Disease Hospital named after S. P. Botkin, Yakovlev Alexey ,   St. Petersburg State University,   City Insurance Medical Company, Gordeeva Svetlana ,   Clinical Infectious Disease Hospital named after S. P. Botkin, Noskova Tatiana ,   Clinical Infectious Disease Hospital named after S. P. Botkin, Komarova Alexandra ,   St. Petersburg State University
Published: October 2024

Infectious diseases caused by resistant pathogens are a serious public health problem. Generalized forms of resistant infections involving the vascular system in the pathological process are often associated with the irrational use of antimicrobial drugs. The pandemic of a new coronavirus infection (COVID-19) was a significant factor that determined further negative trends in the development of antibiotic resistance. The aim of the study was to investigate the spectrum of microorganisms and analyze clinical and epidemiological data in patients with COVID-19 and bloodstream infections caused by resistant bacterial pathogens in the first 10 months of the pandemic. It has been shown that resistant gram-negative microorganisms are the leading etiological cause of bloodstream infections among hospitalized patients. A. baumannii, as a mono-etiological agent or as part of microbial associations, is the predominant causative pathogen of generalized infections in COVID-19 patients. A high level of comorbidity according to the Charlson index and previous courses of antibiotic therapy can be regarded as potential out-hospital predictors of contamination by resistant pathogens. The severe course of the COVID-19 including of the phenomenon of immunosuppression and the occurrence of sepsis determine the high level of hospital mortality. The addition of generalized infections is an extremely unfavorable factor that worsens the prognosis for recovery.
Fundamental jurisprudence as a strategic basis for national legal leadership
Authors:   Kutafin Moscow State Law University, Kabyshev Sergey V.
Published: October 2024

The current stage of historical development is characterized by the tendency of an increasing value and ideological crisis, directly related to the crisis of legal understanding, spiritual, moral, civilizational and cultural disorientation of jurisprudence. The unifying humanity and the legal values it has suffered have been shaken by the policy of single-vector globalization, which has called into question national identity and the primordial possibility of peoples to self-determination. The methods of dictate, unilateral sanctions, and hybrid forms of aggression that have entered into current international use, based on ideas about the exclusivity and dominance of a certain form of legal culture and civilization, destroy the sovereign equality of states, and have nothing to do with the laws of natural history development. The need to form a new global legal paradigm and substantiate the intrinsic value of domestic law as the normative embodiment of Russian civilization require the mobilization of domestic fundamental jurisprudence, which is currently experiencing a number of difficulties and is characterized by negative development trends. This concerns, in particular, the disclosure in our jurisprudence of the historical, civilizational and cultural factors of the Russian legal system, the development of the ideological and philosophical potential of the national legal heritage, the establishment of systematic work to update the methodology of legal cognition, taking into account fundamental changes in the world and in the national worldview, thematic and substantive consistency of research work with the priorities of state development. Increasing the role of fundamental disciplines in legal education and its constitutionalization, revealing the unity of the Russian state and law, the original foundations of our legal system, focusing on a predictive approach that allows us to form advanced models of legal regulation, coordinating the topics of scientific and legal research in accordance with national priorities — key areas in the field of fundamental jurisprudence.
General view on interaction of criminal, administrative-delict and administrative laws in prevention of unlawful activities
Authors:   Baikal State University, Smolyakov Pavel N.
Published: October 2024

The article provides an overview of the relationship between the Criminal Code, the Administrative Offenses Code of the Russian Federation in the prevention of illegal behavior. In this country, historically, those laws serve as effective tools for managing public processes and their interaction in the relevant field is extremely important. Their common problems are especially challenging today as the legislators prepare to adopt a wholly new version of the Administrative Offenses Code, which should be synchronized with “senior” criminal legislation; and they both will have to rely on the laws governing prevention from administrative perspectives. Taking into account conventionality of some kind of division of illegal acts into administrative offenses, misdemeanors (their introduction into the Russian law is also on the agenda) and crimes, the prevention of the administrative delinquency becomes an integral element of the crime prevention in general. So the author supports the idea of creating a unified preventive system which should also involve a number of other pertinent acts of the actual policing legislation: Law on Police, Law on Administrative Supervision, Law on Foundations of System for Prevention of Neglect and Juvenile Delinquency, and others. The declared main point of the laws’ current interaction is the administrative “res judicata”, disputes around which in the criminal law also cover the issues of crime prevention. In addition, effective prevention must be ensured by building now lacking an adaptable and balanced system of criminal and administrative penalties, conforming to each other.
Methods of judicial argumentation in case of semantic uncertainty of a legal text
Authors:   St. Petersburg State University, Fatalieva Daria A.
Published: October 2024

While in non-legal texts linguistic uncertainty either does not hinder normal linguistic practices or can be removed by clarifications, the elimination of uncertainty in legal texts is complicated since peculiarities of legal language precludes its complete exclusion. Accordingly, the task of overcoming legal uncertainty is delegated to the judge and the question arises as to what methods of dealing with the legal text are applicable. The article examines the approaches distinguished in the theory of legal argumentation to assess whether they can offer a methodology which will be able to overcome the policy consequences of the language “open texture” as a characteristic of uncertainty of the natural language in which legal texts are presented by formalizing the process of choosing one of the possible options of the legal text interpretation in judicial decisions. The author concludes that the methods to deal with an uncertain legal text offered by the topicalrhetorical and dialectical approach are limited to the formulation of requirements for the process of argumentation (which do not guarantee absolute predictability of the decision to be made), as well as criteria to evaluate the justification of the decision retrospectively. In turn, the possibility to critically assess the arguments limits the arbitrariness, forcing the judge to follow standards of acceptability and sufficiency of the reasoning to justify their decision.
The Nuclear Energy Agency under the Organization for Economic Cooperation and Development: Legal status, research projects, international cooperation
Authors:   Ministry of Foreign Affairs of Russian Federation, Lebedeva Yulia V.
Published: October 2024

The article deals with the legal status, scientific and international activities of the Nuclear Energy Agency under the Organization for Economic Cooperation and Development (OECD NEA). The outcome of the struggle between Great Britain and France in 1957 was the emergence in the European space of two international organizations dealing with the problems of the peaceful use of atomic energy — Euratom and the OECD NEA. The legal status, structure, procedure for joining the OECD NEA were adopted in its Statute of 1957, which is valid with amendments and additions in the 1995 edition. The OECD NEA does not have international legal personality and treaty standing; these functions can only be exercised with the consent of the OECD Secretariat. The OECD NEA is engaged in the exchange of information, the compilation of best practices, the promotion of scientific and technical projects and research activities, and the development of nuclear law. Under the auspices of the organization, 58 international research projects are being carried out. The OECD NEA cooperates with the IAEA, the European Commission of the EU, and EURATOM, ASEANTOM, African Commission on Nuclear Energy (AFCONE), Inter-American Nuclear Energy Commission. Russia became a full member of the OECD NEA in 2013 and participated in a number of research projects. Based on the Decision of the OECD Secretariat, which was motivated by the special military operation of the Russian Federation on the territory of Ukraine, the DPR and the LPR, Russian membership in all bodies in the organization was officially suspended on May 11, 2022. The politicized refusal of the OECD NEA from the scientific potential of Russia, on the one hand, “impoverished” the Agency, and on the other hand, did not add to it international prestige.
Reconsidering the “Google effect”: Reduced productivity in externalized information recognition is expedient
Authors:   Lomonosov Moscow State University, Vzorin Gleb ,   Institute of Psychology of the Russian Academy of Sciences, Bukinich Alexey ,   Lomonosov Moscow State University,   Scientific and Practical Center for Child Psychoneurology of the Moscow Health Department, Neourkova Veronika ,   Lomonosov Moscow State University
Published: October 2024

The decrease in an ability to independently recall information when it is externalized (e. g., stored on digital devices), also known as the “Google effect”, has become a subject of empirical investigation and a growing concern regarding the Internet’s negative impact on cognition. Several studies have questioned the reproducibility of this effect; however, recent work has replicated it under conditions where participants were confident in the reliability of subsequent access to the information, or in other words, in their ability to use the information in future activities. The findings of this study suggest that the mnemonic “Google effect” may be expedient, meaning that the reduction in recall of information stored on an external source does not occur “automatically”, as previously thought, but in accordance with an individual’s current purposeful and holistic activity. To test this hypothesis, we conducted an empirical study (N = 69, Me = 20 years) that simulated the work of detective, who assisted the police in investigating crimes. Initially, participants were presented with graphic stimuli (“clues”), with instructions based on a narrative explaining what action to take with each (delete, save, scroll through) and how much the material would be needed later (remember the clue, do not remember, or no clear objective). One week later, there was a memory test that involved recognizing and selecting stimuli from the first part, as part of the investigative activity in a detective story. Significantly, clues that needed to be remembered and deleted were recognized more often compared to those that needed to be remembered and saved or skipped. Meanwhile, clues that did not need to be remembered were recognized at the same level regardless of the action taken, significantly better than guess level. Thus, the mnemonic “Google effect” was reproduced, but only under conditions where the externalization of information was purposeful.
Impacto na vida de mulheres ao se tornarem mãe de portadores de necessidades especiais: revisão integrativa
Authors: Lima Mônica Moura da Silveira , Silva Rose Mary Costa Rosa Andrade , Pereira Eliane Ramos , De Deus Vilza Aparecida Handan , De Paulo De Moura Verônica Bessa , Silva Rita de Cássia Ferreira da
Published: October 2024

Objetivo: analisar estudos referentes ao impacto  na vida de mulheres ao se tormarem mãe de  portadores de necessidades especiais. Métodos: revisão integrativa por meio das bases de dados: National Library of Medicine National Institutes of Health (PubMed), Medical Literature Analysis and Retrieval System Online (MEDLINE), Cummulative Index to Nursing and Allied Health Literature (CINAHL) e SCOPUS. Resultados: estudos demonstram alterações no cotidiano familiar, social e emocional, como estresse e depressão de mães de filhos portadores de necessidades especiais. O apoio familiar e profissional agregam de maneira significativa o enfrentamento das questões vivenciadas por essa população. Conclusão: o apoio profissional, familiar e social têm impacto direto na saúde física e emocional de mulheres com filhos portadores de necessidades especiais, portanto, compreender questões do mundo vivenciado por essas mulheres visa contribuir na elaboração de políticas públicas para essa população. Contribuições para a prática: identificar questões relacionadas a mulheres mães de pessoas portadoras de necessidades especiais, instrumentaliza gestores e equipe multitisciplinar acerca da proposta e execução de políticas públicas direcionadas a essa população, que muitas vezes se encontra na invisibilidade social.
Palavras-Chave: Adaptação Psicológica; Crianças com Deficiência; Necessidades e Demandas de Serviços de Saúde; Percepção; Relação Materno-Filial.
Puerpério: os desafios da chegada de um bebê
Authors: Ribeiro Kathleen Cristine Araújo , Santos Margarida Maria Donato dos , Carreiro Mônica de Almeida , Souza Alessandra da Silva , Silva Jannaína Sther Leite Godinho da , Gonçalves Sebastião Jorge da Cunha
Published: October 2024

O presente artigo é uma revisão bibliográfica que analisou os desafios da chegada de um bebê para a puérpera e sua família, com o objetivo de descrever esses desafios e identificar os fatores facilitadores e dificultadores desse período de transição. Foi possível observar que o puerpério apresenta uma série de desafios que podem impactar a saúde física, emocional e social da puérpera e de sua família. Entre os desafios identificados, destacam-se as mudanças físicas e fisiológicas enfrentadas pela puérpera, a fadiga e a falta de sono devido às demandas do bebê, a insegurança e a ansiedade relacionadas aos cuidados com o recém-nascido, as mudanças nas relações familiares e no relacionamento conjugal, e a sobrecarga de tarefas e responsabilidades. Por outro lado, também foram identificados fatores facilitadores que podem auxiliar na adaptação da puérpera e de sua família a essa nova fase. O suporte emocional e prático da rede de apoio, a participação ativa do parceiro, o acesso a informações adequadas sobre cuidados com o bebê, o acompanhamento profissional e a existência de políticas públicas e programas de apoio são elementos-chave que podem contribuir para uma experiência mais positiva no puerpério.
Palavras-Chave: puerpério; desafios; cuidados de enfermagem; recém-nascido.
A importância do aleitamento materno na primeira hora de vida do recém-nascido: conhecimento a estratégia do enfermeiro.
Authors: Macedo Nathália Soares de Oliveira Müller de , Souza Alessandra da Silva , Silva Catia Maria dos  Santos Diogo da , Lima Thainá Oliveira , Ribeiro Mario Luiz Jacobino , Nascimento José Carlos do
Published: October 2024

O presente estudo teve por objetivo analisar de que forma a influência do manejo clínico favorece para a prática do Aleitamento Materno e descrever possíveis Diagnósticos de Enfermagem, de interesse na primeira hora de vida. O método utilizado foi de estudo qualitativo, exploratório, descritivo, realizado por meio de revisão integrada da literatura. O teórico de Enfermagem utilizado foi a Teoria das Necessidades Humanas Básicas de Wanda de Aguiar Horta, o seu objetivo principal é apoio ou cuidado de pessoas de forma autônoma de acordo com suas necessidades básicas. A pesquisa trouxe como resultados três categorias, essas são: Benefícios do Aleitamento Materno na primeira hora de vida do RN, principais diagnósticos de enfermagem na primeira hora e Estratégias da enfermagem utilizadas no manejo clínico para promoção do aleitamento materno. Sistematização da Assistência de Enfermagem como estratégia eficaz, sua implementação é uma ferramenta de comunicação que possibilita atividades efetivas do enfermeiro no apoio ao lactente e estimula subsídios para o planejamento, coordenação e avaliação das intervenções de cuidado. Conclui-se que a enfermagem possui múltiplas estratégias de promoção do aleitamento materno na primeira hora de vida.
Palavras-Chave: Aleitamento Materno; Enfermagem; Neonatal.
A importância da participação do pai no pré-natal
Authors: Miraglia dos Santos Matheus Ferreira da Luz , Pereira Cassiano José de Almeida , Nascimento José Carlos do , Rodrigues Lilia Marques Simões , Gomes Elisângela Nascimento Fernandes , Ribeiro Mário Luiz Jacobino
Published: October 2024

Introdução: a participação do pai durante a gestação é de suma importância para o fortalecimento do vínculo familiar, e para o bem-estar da gestante, podendo o pai ser um ponto de equilíbrio e apoio. O objetivo geral do presente estudo é analisar as evidências disponíveis na literatura sobre a importância do envolvimento do pai durante o período pré-natal. Metodologia: Trata-se de um estudo bibliográfico do tipo revisão integrativa, que se baseia em literaturas estruturadas, obtidas de livros e artigos científicos provenientes de bibliotecas convencionais e virtuais. Análise e discussão dos resultados: Evidenciou-se que a presença do pai durante a gravidez vai além do aspecto emocional e simbólico, tendo impactos tangíveis na saúde física e mental da mãe, demonstrando a redução dos níveis de estresse e ansiedade, capaz de ocasionar uma gestação mais tranquila, contribuindo para o bem-estar geral da mãe. Além disso, a interação precoce entre o pai e o feto influencia positivamente o desenvolvimento cognitivo e emocional da criança desde as fases iniciais da vida intrauterina. Considerações finais: ao reconhecer a importância da participação do pai no período pré-natal, não estamos apenas melhorando o bem-estar das famílias, mas também investindo no desenvolvimento saudável e equilibrado das futuras gerações, visto que a presença e o apoio ativo do pai durante a gravidez são componentes cruciais da jornada da maternidade e da paternidade.
Palavras-chave: Enfermagem; Paternidade; Pré-Natal; Participação.
Itinerário terapêutico da mulher com câncer de colo uterino
Authors: Peters Letícia Helen , Farão Elayne Miguel Delvivo , Fonseca Adélia Dayane Guimarães , Paiva Andyara do Carmo Pinto Coelho
Published: October 2024

Objetivo: descrever o itinerário terapêutico da mulher com câncer de colo uterino na rede de atenção à saúde, desde o rastreamento da doença até após o tratamento. Materiais e Métodos: estudo descritivo, de abordagem qualitativa, realizado no ambulatório de ginecologia oncológica, na Zona da Mata Mineira, de março a julho de 2023. Constituíram-se participantes treze mulheres diagnosticadas com câncer de colo de útero que estão em tratamento ou acompanhamento após o tratamento. A coleta de dados ocorreu por meio de entrevista semiestruturada e a análise conforme o método proposto por Bardin. Resultados: emergiram duas categorias temáticas: o itinerário terapêutico da mulher desde o aparecimento dos sintomas até o diagnóstico do câncer de colo de útero; o itinerário terapêutico da mulher no tratamento e acompanhamento pós-tratamento. Ao longo desse itinerário a mulher enfrenta diversos desafios no acesso aos serviços de saúde, que podem impactar o processo de tratamento e restabelecimento da saúde, como o acesso limitado aos serviços disponíveis na rede de atenção e a delonga para conseguir atendimento. Considerações finais: Compreender o itinerário terapêutico da mulher com câncer de colo uterino é fundamental para identificar possibilidade de avanço no sistema único de saúde. Acredita-se que a enfermagem e outros profissionais de saúde podem aprimorar a comunicação, desenvolver intervenções personalizadas e promover programas de educação para a saúde mais eficazes, visando a prevenção e diagnóstico precoce.
Palavras-Chave: Neoplasias do Colo do Útero; Acesso aos Serviços de Saúde; Itinerário Terapêutico.
Documentos musicográficos como dispositivos de memória cultural
Authors: Sousa Ana Claudia Medeiros de , Oliveira Bernardina Maria Juvenal Freire de
Published: October 2024

Esta pesquisa teve o objetivo de identificar os elementos constituintes do documento musicográfico e se esses evidenciam indícios de memória cultural e da identidade do compositor. Trata-se de uma pesquisa bibliográfica e documental, com uso do método indiciário. A análise e a interpretação dos dados foram pautadas na abordagem qualitativa. Os resultados indicaram que o documento musicográfico reúne elementos da estrutura social, elementos musicais e elementos tecnológicos capazes de revelar o contexto da produção do item documental, como também os traços de memória e identidade do compositor. Portanto, o estudo conclui que a composição musical pode ser considerada um significativo dispositivo de memória cultural.
Synthesis of Novel Indolyl Aryl Sulfone-clubbed Hydrazone Derivatives as Potential HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Molecular Modeling and QSAR Studies
Authors: Ali Hazrat , Latif Abdul , Ali Mumtaz , Ammara  , Waqas Muhammad , Ahmad Manzoor , Khalid Asaad , Khan Ajmal , Al-Harrasi Ahmed
Published: October 2024

Background:

Non-Nucleoside Reverse Transcriptases Inhibitors (NNRTIs)
are among the most extensively studied enzymes for understanding the biology of Human
Immunodeficiency Viruses (HIV) and designing inhibitors for managing HIV infections.
Indolyl aryl sulfones (IASs), an underexplored class of potent NNRTIs, require
further exploration for the development of newer drugs for HIV.

Aims:

In this context, we synthesized a series of novels by Indolyl Aryl Sulfones with a
hydrazone moiety at the carboxylate site of the indole nucleus. A 2D-QSAR model was
developed to predict Reverse Transcriptase inhibitory activity against wild-type RT
(WT-RT) enzyme.

Method:

The model was successfully applied to predict the HIV-1 inhibitory activity of
known Indolyl Aryl Sulfones. Considering the reliability, robustness, and reproducibility
of the 2D-QSAR model, we made an in-silico prediction of the RT inhibition for our
synthesized compounds (1-14).

Results:

Molecular docking and dynamics simulations established our synthesized Indolyl
Aryl Sulfones, particularly compounds 23, 24, and 28, as effective NNRTIs by stabilizing
HIV reverse transcriptase's structure. Binding energy calculations revealed compound
28 as the strongest inhibitor (-43.21 ± 0.09 kcal/mol), followed by 23 (-40.94 ±
0.10 kcal/mol) and 24 (-39.18±0.08 kcal/mol), emphasizing their binding affinity towards
HIV reverse transcriptase.

Conclusion:

In summary, the synthesized Indolyl Aryl Sulfones, particularly compounds
23, 24, and 28, demonstrate significant potential as Non-Nucleoside Reverse
Transcriptase Inhibitors (NNRTIs) against HIV. These results highlight the promising
role of these compounds in developing novel NNRTIs for managing HIV infections.
Click Reaction Inspired Enzyme Inhibitors in Diabetes Care: An Update in the Field of Chronic Metabolic Disorder
Authors: Mudgal Deeksha , Yadav Nisha , Srivastava Gaurav Kumar , Mishra Manish , Mishra Vivek
Published: October 2024

Diabetes is a chronic metabolic disorder that impacts all age groups and affects a large population
worldwide. Humans receive glucose from almost every food source, and after absorption from the gut, it
reaches the liver, which functions as the distribution center for it. The insulin-responsive glucose transporter
type 4 (GLUT-4) is a major carrier of glucose to the various cells (majorly expressed in myocytes, adipocytes,
and cardiomyocytes) in a well-fed state. In fasting periods, the glucose supply is maintained by glycogenolysis
and gluconeogenesis. In diabetes, the distribution of glucose is hampered due to several reasons. Furthermore,
to treat this disorder, several drugs have been synthesized, and click chemistry plays an important role.
A more recent concept for producing pharmaceuticals with a click chemistry approach makes any reaction
more practical and stereospecific, along with a higher yield of products and a smaller number of by-products.
This approach comprises a compiled study of the activity of numerous compelling antidiabetic drugs containing
1,2,3-triazole derivatives supported by click chemistry. In this review, we discuss the synthetic antidiabetic
drugs made via click chemistry and their commendable role in improving diabetes care.
Molecular Docking to Predict a Novel Bioactive Compound as an Inhibitor of Beta Catenin in Oral Squamous Cell Carcinoma
Authors: Kannan Neha , Ramalingam Karthikeyan , Ramani Pratibha , E Dilipan
Published: October 2024

Background:

Efforts aimed at enhancing patient survival have focused on early detection
and diagnosis, followed by prompt treatment of potentially malignant disorders, aiming to halt their
advancement into oral cancer. Recent research has shed light on the pivotal role of the Wnt/B-catenin
signaling pathway in the pathogenesis of potentially malignant oral conditions. This pathway undergoes
a progressive activation process across various degrees of epithelial dysplasia, including mild,
moderate, and severe dysplasia. Beta-catenin (B-catenin) triggers the activation of genes associated
with crucial cellular processes, which include cell growth, viability, differentiation, and migration.

Aims:

In the present study, we aimed to design a novel drug with 3 bioactive compounds through insilico
analysis, assess its efficacy against B-catenin, and develop a new pharmacophore with an emphasis
on B-catenin inhibition.

Materials and Methods:

Based on prior literature, three molecules possessing potent beta-cateninblocking
properties were selected, namely rosmarinic acid, zosterin, and stigmasterol. To evaluate
their binding affinities, molecular docking studies were conducted using the Lamarckian Genetic Algorithm
implemented in AutoDock Tools 1.5.7. Initially, AutoGrid was employed to construct a grid
box for docking purposes. The estimated binding poses of each compound were subjected to clustering
analysis. The interactions between the compounds and beta-catenin were visualized and explored
using PyMOL software.

Results:

Stigmasterol displayed the most substantial binding energy with a value of -3.86 kcal/mol,
followed by rosmarinic acid and zosterin.

Conclusion:

Bioactive components can be used for beta-catenin pathway blocking. Future research
should be carried out to assess these substances in more clinically relevant cancer models.
CLPr_in_ML: Cleft Lip and Palate Reconstructed Features with Machine Learning
Authors: Chen Baitong , Li Ning , Bao Wenzheng
Published: October 2024

Background:

Cleft lip and palate are two of the most common craniofacial congenital malformations
in humans. It influences tens of millions of patients worldwide. The hazards of this disease
are multifaceted, extending beyond the obvious facial malformation to encompass physiological functions,
oral health, psychological well-being, and social aspects.

Objective:

The primary objective of our study is to demonstrate the importance of imaging in detecting
cleft lip and palate. By observing the morphological and structural abnormalities involving the lip
and palate through imaging methods, this study aims to establish imaging as the primary diagnostic
approach for this disease.

Methods:

In this work, we proposed a novel model to analyze unilateral complete cleft lip and palate
after velopharyngeal closure and non-left lip and palate patients from the Department of Stomatology
of Xuzhou First People's Hospital, Conical Beam CT (CBCT) images in silicon. In order to demonstrate
the generalization, the simulated dataset was constructed using the random disturbance factor,
which is from the actual dataset. We extracted several raw features from CBCT images in detail.
Then, we proposed a novel feature reconstruction method, including six types of reconstructed factors,
to reconstruct the existing features. Then, the reconstructed features weretrained with machine learning
algorithms. Finally, the testing and independent data model was utilized to analyze the performance
of this work.

Results:

By comparing different operator features, the min operator, max operator, average operator, and
all operators can achieve good performances in both the testing set and the independent set.

Conclusion:

With the different operator features, the majority of classification models, including Gradient
Boosting, Hist Gradient Boosting, Multilayer Perceptron, lightGBM, and broadened learning, classification
algorithms can get the well-performances in the selected reconstructed feature operators.
Therapeutic Effects of Crocin Nanoparticles Alone or in Combination with Doxorubicin against Hepatocellular Carcinoma In vitro
Authors: Basuony Noha S. , Mohamed Tarek M. , Beltagy Doha M. , Massoud Ahmed A. , Elwan Mona M.
Published: October 2024

Objective:

Crocin (CRO), the primary antioxidant in saffron, is known for its anticancer properties.
However, its effectiveness in topical therapy is limited due to low bioavailability, poor absorption, and low physicochemical
stability. This study aimed to prepare crocin nanoparticles (CRO-NPs) to enhance their pharmaceutical
efficacy and evaluate the synergistic effects of Cro-NPs with doxorubicin (DOX) chemotherapy on two cell
lines: human hepatocellular carcinoma cells (HepG2) and non-cancerous cells (WI38).

Methods:

CRO-NPs were prepared using the emulsion diffusion technique and characterized by transmission
electron microscopy (TEM), scanning electron microscopy (SEM), Zeta potential, and Fourier transform infrared
spectroscopy (FT-IR). Cell proliferation inhibition was assessed using the MTT assay for DOX, CRO, CRO-NPs,
and DOX+CRO-NPs. Apoptosis and cell cycle were evaluated by flow cytometry, and changes in the expression
of apoptotic gene (P53) and autophagic genes (ATG5 & LC3) were analyzed using real-time polymerase chain
reaction.

Results:

TEM and SEM revealed that CRO-NPs exhibited a relatively spherical shape with an average size of 9.3
nm, and zeta potential analysis indicated better stability of CRO-NPs compared to native CRO. Significantly
higher antitumor effects of CRO-NPs were observed against HepG2 cells (IC50 = 1.1 mg/ml and 0.57 mg/ml)
compared to native CRO (IC50 = 6.1 mg/ml and 3.2 mg/ml) after 24 and 48 hours, respectively. Annexin-V assay
on HepG2 cells indicated increased apoptotic rates across all treatments, with the highest percentage observed in
CRO-NPs, accompanied by cell cycle arrest at the G2/M phase. Furthermore, gene expression analysis showed
upregulation of P53, ATG5, and LC3 genes in DOX/CRO-NPs co-treatment compared to individual treatments.
In contrast, WI38 cells exhibited greater sensitivity to DOX toxicity but showed no adverse response to CRONPs.

Conclusion:

Although more in vivo studies in animal models are required to corroborate these results, our findings
suggest that CRO-NPs can be a potential new anticancer agent for hepatocellular carcinoma. Moreover, they
have a synergistic effect with DOX against HepG2 cells and mitigate the toxicity of DOX on normal WI38 cells.
Development and Prospect of Space Debris Protection Structures for Spacecraft
Authors: Zhang Yuan , Li Tianyu , Lu Shuai , Zhou Enwen
Published: October 2024

Background:

As the pace of human conquest of space continues to accelerate, the number
of spacecraft carrying out various activities in space continues to increase, so that the available orbital
space continues to decrease, the amount of space debris continues to increase, and thus the
probability of orbiting spacecraft being impacted by space debris is also increasing. Research on the
development of protective structures in the current state is conducive to improving the protection
performance of spacecraft protective structures against space debris, reducing the occurrence of
spacecraft disintegration events and spacecraft collision events, and may also promote the development
of many fields through the development of new technologies.

Aim:

Through the latest application and development of spacecraft, the advantages and disadvantages
of various protection structures are summarized, and the development trend of academic
and aerospace protection engineering is analyzed.

Methods:

Through the latest representative patent research methods for spacecraft space debris, research
content, and creative structure, the principle and characteristics of the protective structure are
demonstrated.

Results:

By comparing the application of different spacecraft space debris protection structures, the
existing problems of the current protection structures are listed, and the potential development paths
and research topics are put forward

Conclusion:

The development of aerospace, military, and other industries benefit from the development
of protective structures, and the composite spacecraft space debris protection structures have
broad development prospects.