bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeting Nanodiamonds to the Nucleus in Yeast Cells
Authors: Morita Aryan , Hamoh Thamir , Sigaeva Alina , Norouzi Neda , Nagl Andreas , van der Laan Kiran J. , Evans Emily P. P. , Schirhagl Romana
Published: October 2020

Nanodiamonds are widely used for drug delivery, labelling or nanoscale sensing. For all these applications it is highly beneficial to have control over the intracellular location of the particles. For the first time, we have achieved targeting the nucleus of yeast cells. In terms of particle uptake, these cells are challenging due to their rigid cell wall. Thus, we used a spheroplasting protocol to remove the cell wall prior to uptake. To achieve nuclear targeting we used nanodiamonds, which were attached to antibodies. When using non-targeted particles, only 20% end up at the nucleus. In comparison, by using diamonds linked to antibodies, 70% of the diamond particles reach the nucleus.
Modeling of Biofilm Growth on Fine Spherical Particles with the Use of Cellular Automata: The Influence of Cell Death and Lysis on the Biofilm Structure
Authors: Skoneczny Szymon , Cioch-Skoneczny Monika
Published: October 2020

The paper concerns the modeling of heterogeneous biofilm growth on fine spherical particles of such biofilm forms as, e.g., fluidized-bed bioreactors. Three discrete mathematical models based on cellular automata theory were proposed. The double-substrate kinetics of biomass growth, biomass displacement, internal and external mass transfer resistances, death and lysis of microbiological cells and biofilm detachment were taken into account. It was shown that there are no significant qualitative and quantitative differences between biofilm growth on flat and spherical particles of different radii. Computer simulations were compared with experimental observations. Qualitative and quantitative agreement areachieved if both cell death and lysis aretaken into consideration and a proper algorithm of biomass displacement is used. The value of the bacteria lysis rate coefficient was estimated.
Raman Signal Enhancement Tunable by Gold-Covered Porous Silicon Films with Different Morphology
Authors: Agafilushkina Svetlana N. , Žukovskaja Olga , Dyakov Sergey A. , Weber Karina , Sivakov Vladimir , Popp Jürgen , Cialla-May Dana , Osminkina Liubov A.
Published: October 2020

The ease of fabrication, large surface area, tunable pore size and morphology as well surface modification capabilities of a porous silicon (PSi) layer make it widely used for sensoric applications. The pore size of a PSi layer can be an important parameter when used as a matrix for creating surface-enhanced Raman scattering (SERS) surfaces. Here, we evaluated the SERS activity of PSi with pores ranging in size from meso to macro, the surface of which was coated with gold nanoparticles (Au NPs). We found that different pore diameters in the PSi layers provide different morphology of the gold coating, from an almost monolayer to 50 nm distance between nanoparticles. Methylene blue (MB) and 4-mercaptopyridine (4-MPy) were used to describe the SERS activity of obtained Au/PSi surfaces. The best Raman signal enhancement was shown when the internal diameter of torus-shaped Au NPs is around 35 nm. To understand the role of plasmonic resonances in the observed SERS spectrum, we performed electromagnetic simulations of Raman scattering intensity as a function of the internal diameter. The results of these simulations are consistent with the obtained experimental data.
Design, Implementation and Simulation of a Fringing Field Capacitive Humidity Sensor
Authors: Petre Adrian-Razvan , Craciunescu Razvan , Fratu Octavian
Published: October 2020

The world population is growing in an accelerated way urging the need for a more efficient and sustainable agricultural industry. Initially developed for smart cities which face the same challenges caused by an increasing population, Internet of Things (IoT) technologies have evolved rapidly over the last few years and are now moving successfully to agriculture. Wireless Sensor Networks (WSNs) have been reported to be used in the agri-food sector and could answer the call for a more optimized agricultural management. This paper investigates a PCB-made interdigited capacitive (IDC) soil humidity sensor as a low-price alternative to the existing ones on the market. An in-depth comparative study is performed on 30 design variations, part of them also manufactured for further investigations. By measurements and simulations, the influence of the aspect ratio and dielectric thickness on the sensitivity and capacitance of the sensor are studied. In the end, a Humidity and Temperature Measurement Wireless Equipment (HTMWE) for IoT agriculture applications is implemented with this type of sensor.
Equipment Anomaly Detection for Semiconductor Manufacturing by Exploiting Unsupervised Learning from Sensory Data
Authors: Chen Chieh-Yu , Chang Shi-Chung , Liao Da-Yin
Published: October 2020

In-line anomaly detection (AD) not only identifies the needs for semiconductor equipment maintenance but also indicates potential line yield problems. Prompt AD based on available equipment sensory data (ESD) facilitates proactive yield and operations management. However, ESD items are highly diversified and drastically scale up along with the increased use of sensors. Even veteran engineers lack knowledge about ESD items for automated AD. This paper presents a novel Spectral and Time Autoencoder Learning for Anomaly Detection (STALAD) framework. The design consists of four innovations: (1) identification of cycle series and spectral transformation (CSST) from ESD, (2) unsupervised learning from CSST of ESD by exploiting Stacked AutoEncoders, (3) hypothesis test for AD based on the difference between the learned normal data and the tested sample data, (4) dynamic procedure control enabling periodic and parallel learning and testing. Applications to ESD of an HDP-CVD tool demonstrate that STALAD learns normality without engineers’ prior knowledge, is tolerant to some abnormal data in training input, performs correct AD, and is efficient and adaptive for fab applications. Complementary to the current practice of using control wafer monitoring for AD, STALAD may facilitate early detection of equipment anomaly and assessment of impacts to process quality.
An Actuator Allocation Method for a Variable-Pitch Propeller System of Quadrotor-Based UAVs
Authors: Chang Ching-Wei , Chen Shengyang , Wen Chih-Yung , Li Boyang
Published: October 2020

This paper presents a control allocation method for enhancing the attitude following performance and the energy efficiency of a variable-pitch propeller (VPP) system on quadrotor-based unmanned aerial vehicles. The VPP system was modeled according to the blade element momentum (BEM) theory, and an actuator allocation method was developed with the aim of enhancing the attitude control and energy performance. A simulation environment was built to validate the VPP system by creating a thrust and moment database from the experiments. A four-motor variable-pitch quadrotor was built for verifying the proposed method. The control allocation method was firstly verified in a simulation environment, and was then implemented in a flight controller for indoor flight experiments. The simulation results show the proposed control allocation method greatly improves the yaw following performance. The experimental results demonstrate a difference in the energy consumption through various pitch angles, as well as a reduction in energy consumption, by applying this VPP system.
DİZİ KARAKTERLERİNİN REKLAMLARDA KULLANILMASININ GÖSTERGEBİLİMSEL ÇÖZÜMLEMESİ: MİMESİS VE FREUDYEN YAKLAŞIM ETKİLEŞİMİ
Authors: KOÇAK Sevinç , TÜPLEK Semra
Published: October 2020

Reklamlar bir ürünün veya markanın hedef kitlelerine tanıtılması ve çeşitli
pazarlama çalışmalarının iletilmesi için günümüzde çok farklı yöntemlerle
kullanılan, zaman ve yer satın alınması ve ücretinin ödenmesi suretiyle işleyen
bir iletişim yöntemidir. Basılı, görsel, işitsel ve dijital medya kanallarında
farklı pek çok yöntemle, mesajlarını hedef kitlelerine iletmeye çalışan
markalar ve ürünler, binlerce mesaj arasından sıyrılıp, istedikleri etkiyi
yaratabilmek için birçok uygulamayı kullanmak durumundadırlar. Reklam
filmlerinde ünlü ve topluma liderlik edebilecek kişilerin, sanatçıların,
tanınmış kişilerin, sevilen kişilerin kullanılması bilinen ve sıkça uygulanan
bir yöntemdir. Böylece marka veya ürünü tüketicisine sevdirmek ve “sevdiğiniz
kişi de bu ürünü kullanmaktadır, siz de kullanın” yönlendirmesi yapılmaktadır.
Çoğunlukla bu kişiler gerçekte de toplumsal hayat içerisinde rastladığımız,
gerçek ve bilinen kişiliklerdir. Reklam filmlerinde sevilen dizi veya film
karakterlerinin kullanılması ise son on yılda karşımıza daha sık çıkan bir
yöntemdir. Film karakterlerinin reklamlarda gerçek kişi imiş gibi
kullanılmasının alt yapısında psikolojik ve sosyolojik olarak etkiler vardır.
Bu çalışmada psikanalist Sigmund Freud’un id, ego ve süperego kavramları ile “taklit”
olarak ele alınan “mimesis” kavramı çerçevesinde reklam filmlerinde dizi
karakterlerinin kullanılmasının hedef kitlelerdeki olası etkileri irdelenmeye
çalışılmaktadır. Bu bağlamda, üç dizi karakterinin oynadığı reklamlar Seiler’in
adımlarıyla film çözümlenmesi yöntemi kullanılarak çözümleme yapılmaktadır.
Sonuçta, reklam filmlerinin sanal gerçek gibi gösterilen dizi karakterleri
kullanılarak ürün ve markaların yaratmak istedikleri algının hedef kitlelere
iletilmesindeki amaç, Freudyen bir bakış açısıyla ortaya konulmaya
çalışılmaktadır.
GELİŞMİŞ VE GELİŞMEKTE OLAN ÜLKELERDE ENFLASYON VE FAİZ ORANLARI ARASINDAKİ NEDENSELLİK İLİŞKİSİ
Authors: BAKTEMUR Fatma İdil
Published: October 2020

Enflasyon ve faiz oranları arasındaki nedensel ilişki iktisat literatüründe uzun bir süreden beri tartışılmaktadır. Bu çalışmada G7 ülkeleri (Kanada, Fransa, Almanya, İtalya, Japonya, İngiltere, ABD) ve gelişmekte olan ülkeler (Çin, Hindistan, Rusya, Singapur, Güney Kore, Güney Afrika, Türkiye) için enflasyon ve faiz oranları arasındaki nedensellik ilişkisi panel veri yaklaşımı ile araştırılmıştır. Veriler 1999-2017 dönemini kapsamaktadır. G7 ülkeleri ve gelişmekte olan ülkeler için enflasyon ve faiz oranları arasında çift yönlü nedensellik bulunmuştur.
Students’ Perceptions towards Ideal Maritime English Teacher
Authors: Anggraini Laila Puspitasari , Ernis Ernis , Jelenska Joanna Maria
Published: October 2020

This paper discusses the perceptions of students about the characteristics of an Ideal Maritime English teachers in a vocational institution. It is an interpersonal point of view regarding of their perceptions of qualities of English teachers and teachers’ immediacy behavior (verbal or non-verbal) as a students’ academic motivation. A total of 60 students of 3 departments of the 2nd level was randomly involved. Results of this study show that students and teachers described the ideal teacher as a person who is friendly, young, enthusiastic, creative and humorous person whose gender is not important. Also, students expect their teacher to be a native speaker of Indonesian but fluent in English, someone who like to play educational games, and who teaches maritime context effectively by using real life situations to explain language item.  The aim of this study is expected to give understanding of how teaching Maritime English in a foreign language context can be better.
The Implementasi Outdoor Education Camping Program Untuk Melatih Kepemimpinan Mahasiswa STKIP Bina Mutiara Sukabumi
Authors: Rafdlal Saeful Bakhri  , Moch Latif  , Debi Krisna Irawan  , Chairul Umam Ramdhan  , Arfin Deri Listiandi
Published: October 2020

Keterampilan kepemimpinan merupakan aspek yang penting bagi mahasiswa pada saat ini atau masa mendatang. Oleh karena itu diperlukan suatu program atau kegiatan yang dapat memberikan kesempatan bagi mahasiswa untuk dapat melatih keterampilan kepemimpinan. Outdoor education melalui program camping merupakan salah satu kegiatan yang tepat untuk mahasiswa. Tujuan dalam penelitian ini adalah untuk menerapkan outdoor education camping program dalam melatih kepemimpinan pada mahasiswa. Outdoor education camping program dilakukan dalam penelitian ini selama 3 hari. Penelitian ini menggunakan metode pre-experiment dengan menggunakan desain penelitian one group pretest-posttest design. Sampel penelitian dipilih dengan menggunakan teknik purposive sampling, diperoleh sebanyak 30 mahasiswa. Instrumen penelitian menggunakan angket kepemimpinan yang terdiri dari 25 item pernyataan dengan menggunakan skala Likert. Analisis data menggunakan paired sample t test. Analisis dilakukan pada taraf signifikansi α = 0,05. Hasil penelitian menunjukan terdapat peningkatan sikap kepemimpinan mahasiswa yang signifikan (Sig = 0,00 < 0,05). Simpulan dalam penelitian ini adalah outdoor education camping program memberikan pengaruh positif dalam melatih kepemimpinan pada mahasiswa.
Sentinel-1 SAR interferometry for agriculture: description of an experiment in Oryol, Russia
Authors: Nico Giovanni , Trofimetz Lyubov , Masci Olimpia
Published: October 2020

In this work we describe an experiment to be carried out in the basin of Suhaya Orlitsa river (Oryol region, central part of European Russia) to compare in-situ measurements of soil moisture with estimates obtained using Synthetic Aperture Radar (SAR) interferometry. The Sentinel-1 mission of the European Space Agency (ESA), acquiring C-band SAR images regularly over all Earth regions since 2014 with a mean revisiting time of 6 days, is used. In-situ measurements of soil moisture are planned in a time interval of 3 hours in coincidence of each Sentinel-1 passage, using a temporal sampling of 15 minutes. Test measurements are planned at the end of the month of April, when the soil accumulates water. The aim of the experiment is to demonstrate the feasibility of using Sentinel-1 images to densify the network of in-situ measurements of soil moisture on the territory of Russia. The application of SAR interferometry is investigated as it requires less in-situ measurements than methods based on the use of radar cross-section and the inversion of models of electromagnetic scattering from natural surfaces. Examples of interferometric coherence and phase images obtained by processing Sentinel-1 images acquired on 20th September 2019 and 2nd October 2019 over the study area are shown.
Amplitude modulation of radiation by coupled resonators
Authors: Kanojka A. I.
Published: October 2020

In this paper, we describe a method that allows one to realize highly efficient amplitude modulation of radiation at the output of electro-optical laser switches with two coupled resonators, in which electro-optical elements are located both in two split arms and in every arm of a multipath interferometer with combined channels with a control voltage 2 times lower than in existing laser switches. Moreover, the electro-optical elements located in the two split arms of a multipath interferometer with combined channels, with one passage of the light flux through the electro-optical element, must make the opposite controlled changes in the phase difference of the interfering light beams. Therefore, for such electro-optical switches with two coupled resonators the value of the required electric power will be, respectively, 2 times less than that of the existing ones, which significantly expands their operating frequency range. In this case, a laser switch with electrooptical elements located in the two split arms of a multipath interferometer has an asymmetric dependence of the output radiation intensity on the change in the phase difference of the interfering light beams relative to the zero value of the light intensity. A laser switch with electro-optical elements located on all arms of a multipath interferometer with combined channels has a symmetric dependence of the output radiation intensity on the magnitude of the phase difference of the interfering light beams relative to the zero value of the light intensity. In addition, due to the coherent summation of the amplitudes of the interfering light waves, such laser electro-optical shutters also have amplification of radiation with a resonant wavelength.
CORRECTION OF LIPID AND HEMOSTATIC DISORDERS IN PATIENTS AT HIGH RISK OF CARDIOVASCULAR DEATH
Authors: Rubanenko OA A , Kirichenko NA A , Fatenkov OV V
Published: October 2020

Aim - to study the peculiarities of lipid and coagulation abnormalities in high risk patients, and also the possibilities of their correction with statin therapy. Methods. 102 patients were studied, 1 group included patients with LDL 3.0-3.9 mmol/l (n=59), who received atorvastatin 40 mg daily with titration to 80 mg daily, 2 group - patients with LDL >4.0 mmol/l (n=48), who received rosuvastatin 10 mg daily with titration to 20 mg daily. Results. In the 1 group of patients, after 24 weeks mean LDL level decreased by 43.3% (p
FORMATION AND DEVELOPMENT OF TEMPORARY DISABILITY EXAMINATION SERVICE IN RUSSIA
Authors: Suslin SA A , Pavlov VV V , Nikolskaya OG G
Published: October 2020

Aim - characterization of the formation, organization, development and prospects of temporary disability examination (TDE) services in Russia. Materials and methods. A review of the data from the scientific publications and legal documents was conducted. Results. The characteristics of the organization and development of temporary disability examination service in Russia since the establishment of the service to date are described. The problems and prospects of TDE service were examined. Conclusion. The organization and development of temporary disability examination in Russia is determined by the formation of the whole healthcare system and by legal acts. The implementation of modern requirements to the temporary disability examination is determined by the challenges faced by healthcare providers, as well as the solution of the problems faced by the subjects of the internal control of activities of healthcare organizations.
METHOD OF DIAGNOSIS OF ORAL MANIFESTATIONS OF HEMATOLOGIC MALIGNANCIES BY USING CONCENTRATIONS OF IMMUNOGLOBULIN A AND G ANTIBODIES TO GLIADINE AND TRANSGLUTAMINASE
Authors: Svechnikova MV V , Gilmiyarov EM M , Selezneva IA A , Fedyaev IM M
Published: October 2020

Aim - developing of the new method of diagnosis of oral manifestations of hematologic malignancies by using concentrations of immunoglobulin A and G antibodies to gliadine and transglutaminase in saliva. Materials and methods. The condition of oral mucosa and concentrations of immunoglobulin A and G antibodies to gliadine and transglutaminase were assessed in 90 patients with acute and chronic leukemia. Results. After polychemiotherapy their oral status and concentrations of immunoglobulin A and G antibodies to gliadine and transglutaminase changed significantly. Conclusion. The study will help develop effective method of diagnosis of oral manifestations of hematologic malignancies.
INTEGRAL ALGORITHM OF P300 RECOGNITION IN EEG FOR BCI APPLICATION
Authors: Agapov S N , Bulanov V A , Zakharov A V , Sergeeva M S , Pyatin V F
Published: October 2020

Aim - developing the integral algorithm of recognition of the evoked potential (ERP-response) to a target visual stimulus and testing of the proposed algorithm on the wireless 5-channel electroencephalograph Emotiv Insight with “dry” electrodes. Materials and methods. The objects of the study were the EEG records of five volunteers. Were used 5-channel wireless EEG headset Emotiv Insight, self-developed software «eSpeller», software environment MathWork® MATLAB R2015a. Results. It was found that the proposed integral algorithm of recognition of electrical activity of the cerebral cortex to a target visual stimulus shows the accuracy of the detection from 71.5% to 90.6% with the average value 80.1+7.2%, using EEG headset Emotiv Insight. Conclusion. The algorithm shows a high level of reliability of recognition of evoked potential to a target visual stimulus, does not require large computing power, sophisticated classification methods and machine learning. The testing of the algorithm suggests the possibility of using the electroencephalograph Emotiv Insight with "dry" electrodes in the development of BCI.
USING VIRTUAL REALITY AS A METHOD OF ACCELERATED REHABILITATION AMONG THE PATIENTS AFTER STROKE
Authors: Zakharov A V , Pyatin V F , Kolsanov A V , Poverennova I E , Segreeva M S , Khivintseva E V , Korovina E S , Kucepalova G U
Published: October 2020

Aim - exploring the effect of displaying the motion from the first-person’s point of view in virtual reality on the recovery of motor disorders among patients in the acute period of cerebrovascular disorder. Materials and methods. 45 patients with acute cerebrovascular disorder aged 58±7 years were analyzed. Patients were randomized in two groups. The first group received either standard rehabilitation or training with virtual reality equipment. The second group received only standard rehabilitation. Training included displaying the motion from the first-person’s point of view in the virtual reality during 3-7 sessions, 15 minutes each. In this exercise a patient could see his “virtual legs”. Speed range was 2-5 km/h. Berg’s balance assessment was used to score movement function (14 questions, where max score - 56 points - means that there is no dysfunction to notice). Assessment method for comparing groups with unusual distribution (Mann-Whitney criteria) was used as statistical analysis. Results. Exercises with the virtual reality equipment show their efficiency on 15th-19th day after stroke. The most significant outcome can be achieved in 5-9 days after stroke (p=0,022). The rate of movement function recovery depends on the duration of training (p=0,001); the highest outcome can be achieved during the first 3-5 sessions. Conclusion. Additional exercises with the virtual reality equipment help to improve outcomes of movement function recovery among patients with acute cerebrovascular disorder.
INNOVATIVE TECHNOLOGIES IN DIAGNOSIS AND TREATMENT OF EXTREME FAMILIAL HYPERCHOLESTEROLEMIA
Authors: Simerzin V V , Fatenkov O V , Gagloeva I V , Galkina M A , Panisheva Ya A , Sytdykov I Kh
Published: October 2020

The article reveals medical and social relevance of extreme familial hypercholesterolemia. It presents the main principles, innovative technologies and an algorithm of diagnosis, diagnostic verification, risk stratification of patients and optimization of the use of aggressive combined cholesterol-lowering drug treatment and precision of indications for plasma exchange and the lack of options.
FEATURES OF THE COLON MUCOSA IN PATIENTS WITH EXACERBATION OF ULCERATIVE COLITIS
Authors: Katorkin S E , Andreev P S , Isaev V R
Published: October 2020

Aim - to study the features of the colon mucosa in patients with exacerbation of ulcerative colitis. Material and methods. Methods of general morphology and morphometry were developed and applied during the examination and treatment of 185 patients with exacerbation of ulcerative colitis in the clinic of hospital surgery from 2004 to 2015. Results. The efficacy of endolymphatic antibacterial and immunostimulating therapy was revealed. When comparing I and II groups of patients with moderate form of the ulcerative colitis, the difference between such indicators as the condition of the epithelium of the crypts and the depth of the lesion was statistically significant (p
MODERN ASPECTS OF THE ETIOLOGY AND PATHOGENESIS OF UTERINE FIBROID TUMORS
Authors: Katorkina ES S , Shatunova EP P
Published: October 2020

Uterine myoma is a benign, hormone-sensitive proliferating tissue. It is one of the most common tumors of women's reproductive system in most countries of the world, and it is often the main cause of hysterectomies, especially among fertile females, determining the social significance of this disease. Domestic and foreign researches are continuing to look for the reasons of this worldwide problem. The article describes the present view on the etiology, pathogenesis and morphogenesis of uterine fibroids. It presents the data on the role of steroid hormones and their receptors, processes of neoangiogenesis, their stimulants and inhibitors (VERGF, EGF, IGF-1, TGF, PDGF, MMPs), proliferation and apoptosis disorders (protooncogene Bcl-2, nuclear phosphoprotein p53). The influence of gene mutations, molecular-genetic markers, as well as immune system mechanisms on tumor growth and development were studied.
CURRENT ASPECTS OF THE CONCEPT, ETIOLOGY, PATHOGENESIS AND PREVENTION OF SUDDEN CARDIAC DEATH
Authors: Fatenkov OV V , Rubanenko OA A , Yashin SS S , Avezova DB B
Published: October 2020

Aim - to highlight current aspects of the concept, etiology, pathogenesis and prevention of sudden cardiac death. Discussion. Sudden cardiac death in a wide sense is known as non-violent death due to cardiac pathology, with the rapid development of circulatory arrest, which is preceded by loss of consciousness. Sudden cardiac death is often the first and only manifestation of coronary heart disease, and it occupies a vast niche in mortality from cardiovascular pathology. Despite the high prevalence, there are many controversial and unresolved issues regarding the pathogenesis of the sudden cardiac death. There are some difficulties with the precise definition of this diagnosis. Conclusion. The review considers the concept of sudden cardiac death, presents several theories of pathogenesis, risk factors, which are thoroughly analyzed and synthesized. Methods of primary and secondary prophylaxis are analyzed, and comparative characteristics of medicinal substances used for prevention of sudden cardiac death are given.
GENERATION OF IL-17 IMMUNE RESPONSE IN OBESE PATIENTS WITH ASTHMA
Authors: Nurdina MS S , Kupaev VI I , Sazonova OV V
Published: October 2020

Aim - to investigate the influence of IL-17, IL-10 on the level of asthma control among obese patients. Materials and methods. 79 patients with asthma aged from 18 to 65 years were enrolled in our study and categorized into three groups according to their body mass index (BMI): group 1 - normal BMI (27 (34,2%) patients, age 50±13,8), group 2 - overweight (28 (35,4%) patients, age 44±16,5) and group 3 - obese (24 patients (30,4%), age 57,3±8,2). These patients underwent spirometry and were compared for clinical characteristics, plasma level of IL-17 and IL-10 using ELISA assay. Results. IL-17 concentrations were higher in the obese and uncontrolled asthmatics. Statistically significant correlation between the level of IL-10 and BMI was not found. Conclusions. Our study shows that cytokines IL-17 play an important role in the immune response of asthma in obese patients, and represent an important therapeutic target for the asthma treatment.
PROBLEMS OF A TB PATIENT AND HIS FAMILY DURING THE PERIOD OF THE ECONOMIC CRISIS
Authors: Puzyreva LV V , Mordyk AV V , Batishcheva TL L
Published: October 2020

Aim - to identify the main social and medical problems of a patient with tuberculosis (TB) and his family that are connected with the economic changes in the country. Materials and methods. We conducted a solid sociological study involving 200 new TB cases during hospital treatment. The analysis of the obtained data was performed. Results. Only one third of the patients were married, even fewer were officially employed. About half of the patients had unrecorded employment, which caused some problems. These patients showed decreased motivation for long-term hospital and sanatorium treatment, as they were afraid of losing their jobs. For the majority of the patients, their professional activity is associated or was associated with unfavourable factors. Some of the respondents blamed their employers for the onset of the disease. The main reason of dissatisfaction of the patients was carelessness of health workers. Furthermore, every third patient with tuberculosis demanded from the phthisiatrician to recognize a disability category in order to improve their financial situation. Conclusion. Changes in the labour legislation have caused the emergence of private organizations that do not comply with requirements for protection of employees, which can affect their health.
DETERMINATION OF BIOCOMPATIBILITY AND CYTOTOXICITY OF POROUS TITANIUM-BASED MATERIALS IN EXPERIMENT
Authors: Kolsanov AV V , Nikolaenko AN N , Ivanov VV V , Prikhodko SA A , Platonov PV V
Published: October 2020

Aim - to evaluate the proliferative activity of dermal fibroblast cultures in the presence of composite materials based on titanium silicides in vitro. Materials and methods. To assess the proliferative activity of dermal fibroblasts in vitro, the following materials were used: titanium silicide, titanium carbosilicide oxidized in vacuum and without vacuum, titanium VT-00 (comparison group). Testing of proliferative activity was carried out by the direct contact method. The proliferation index, the doubling time and the number of culture doubling during the cultivation period were calculated. Attachment of dermal fibroblasts to the surface of the test materials and their presence on it during cultivation was assessed by scanning electron microscopy. Results. The study of the morphofunctional characteristics of dermal fibroblasts cultured in the presence of the test samples of material showed that during the entire experiment no major changes occurred in any of the series, the cells retained the monolayer growth characteristic of fibroblasts, preferably spindleshaped with 2-4 shoots. Moreover, all cultures of dermal fibroblasts underwent the same number of doublings during the experiment and reached saturation density 7 days after sowing, which indicates good proliferative activity of cells in the presence of test materials. The results of scanning electron microscopy demonstrate the high affinity of human dermal fibroblasts for both titanium silicide and titanium carbosilicides. Conclusion. Absence of morphofunctional changes in dermal fibroblasts and active proliferation testify to the absence of cytotoxicity of the investigated alloys, and the ability of cells to adhere to the surface of materials indicates their good biocompatibility.
FEATURES OF THE APPLICATION OF THE NEW METAL FIXATOR FOR OSTEOSYNTHESIS IN OSTEOPENIA IN POST-MORTEM EXAMINATION
Authors: Lartcev YuV V , Shereshovets AA A
Published: October 2020

Aim - to study the peculiarities of osteosynthesis in osteopenia with the application of the new metal fixator in post-mortem studies. Material and methods. New metal fixator for osteosynthesis in osteopenia has been developed. Measurements of the mechanical strength of osteosynthesis, and biomechanical tests of osteosynthesis stability with the application of this fixator were studied in 16 corpses (32 cases). Results. Biomechanical tests indicate that the new metal fixator is able to maintain the optimal position of anatomical reduction in 15 cases out of 16, while using a sponge screw AO type shows this result only in 6 cases out of 10. The mechanical strength of osteosynthesis with the use of the new metal fixator is 2,77 times greater than when using a sponge screw AO type. Conclusion. The carried out post-mortem examination testifies to the advantage of using the new metal fixator compared to the traditionally used sponge screw AO type for osteosynthesis in osteopenia.
NEW APPROACH TO SOLVING THE PROBLEM OF COMPLEX REGIONAL PAIN SYNDROME
Authors: Pankratov AS S , Ardatov SV V , Ogurtsov DA A , Kim YuD D , Shitikov DS S
Published: October 2020

Aim - to improve the results of treatment of patients with complex regional pain syndrome (CRPS) in bone fractures of the lower extremities by applying a new integrated approach. Methods. A new approach to solving the problem of complex regional pain syndrome in fractures of lower limb bones is proposed, including the use of modern minimally invasive methods for surgical treatment of fractures of the lower limb bones, such as blocked osteosynthesis, Fixion technology, use of angular stability plates, metal structures for osteosynthesis of the proximal femur. All these measures help to minimize the negative effect that is produced on the bone by such factors as prolonged immobilization and absence of early movements of the joints, which will make it possible to perform CRPS prophylaxis in bone fractures of the lower limbs more effectively. If it is not possible to prevent the development of CRPS, then it is necessary to administer complex therapy, including psychoemotional correction, adherence to the regime, proper immobilization, rehabilitation exercises, physiotherapy, medical treatment, hyperbaric oxygenation, and gravitational therapy. Results. Clinical tests, radiography, densitometry, method of statistical analysis and mathematical modeling with elements of evidencebased medicine objectively confirmed the activation of the restorative processes in altered tissues of the lower limbs due to the use of the new complex. Conclusion. The analysis of the obtained data of clinical and functional methods of research has proved that the total value of positive results is 80%.
OCCUPATIONAL ASTHMA: DIAGNOSTIC STRATEGY AND ISSUES OF EXPERTISE
Authors: Babanov SA A , Budash DS S , Baikova AG G
Published: October 2020

The review article discusses the issues of epidemiology, etiology, pathogenesis, clinic, diagnostics, differential diagnostics, medical and social expertise, prevention of occupational asthma based on the analysis of domestic and foreign research data.
DIAGNOSTICS OF PHARYNX MYCOSIS
Authors: Reshetnikova V P , Baryshevskaya L A , Zeleva O V , Popov M N
Published: October 2020

Aim - to characterize different methods for diagnosis of mycotic lesions of the pharynx used in medical practice. Materials and methods. This article describes various methods of laboratory diagnostics of tonsillopharyngeal mycosis and their indications; and presents the analysis of 117 adult cases of tonsillopharyngeal mycosis confirmed by the analysis of thick blood film after the incubation in thermoregulator combined with blood agar inoculation. In addition, this method includes a microflora test which in most chronical cases accompanies pharyngeal mycosis. Results. The study revealed relevant advantages of the presented methods of pharynx mycosis diagnostics, which not only detect the presence of mycelium and its morphology, but also evaluate its role in the inflammatory process. In addition, this method includes bacterial culture test that in most chronical cases accompanies pharynx mycosis. Out of 100% only 17.9% of observations (21 patients) showed Candida fungus in parasitic phase as mono-infection, the other 82.1% of cases proved bacterial presence. The most frequent combination was Candida and Streptococcus spp (including pneumococcus) that made up 41.9% of total observations. In 10.3% of cases Staphylococcus spp was detected. Other patients had more than two kinds of microorganisms. The following combinations were revealed: fungi, streptococci and staphylococci in 17.9% cases; fungi and streptococci with Klebsiella and\or Moraxella catarrhalis or other opportunistic pathogenic microflora in 12% cases. Conclusions. The most effective method of research of upper airway mycosis is the one that enables to reveal Candida fungi presence and concentration as well as to identify their status (saprophitic or parasitic) in the patient's body using thick blood microscopy. The value of this method increases with simultaneous evaluation of associated microflora and its relation to macroorganism. Being simple, cost-effective and highly informative, complex method of diagnostics of upper airway mycosis can be widely used in medical practice.
NEW WAYS OF TREATING PERENNIAL ALLERGIC RHINITIS
Authors: Dzhimsheleishvili N P , Ovchinnikov A Yu , Miroshnichenko N A
Published: October 2020

Moscow State University of Medicine and Dentistry n.a. A.I. Evdokimov Selecting the proper treatment of perennial allergic rhinitis (PAR) today is often unsuccessful. At present, PAR is characterized by the early beginning, quite often continuously relapsing course and resistance to antiallergic therapy. Study of the mechanisms of the course of the disease creates a basis for the rational therapy that assumes impact on the composite inflammatory response, not only on allergy symptoms. Aim - to reflect the importance of a modern approach to treatment of patients with perennial allergic rhinitis. Materials and methods. For analysis we decided to conduct a comparative study of monotherapy with topical glucocorticosteroids and combined therapy consisting of topical glucocorticosteroids together with intranasal antihistamine medications. Results. The research showed that the use of the combined therapy with topical glucocorticosteroids and intranasal antihistamine medications can be effective in patients with perennial allergic rhinitis, considerably improving the quality of life.
GERIATRIC HEALTH ASSESSMENT AND HEARING LOSS
Authors: Vladimirova T Yu , Aizenshtadt L V
Published: October 2020

Aim - to examine the results of a comprehensive geriatric assessment depending on the degree of hearing loss. Material and methods. We examined 110 patients aged from 60 to 90 years with bilateral symmetrical impairment of the hearing function. The research design included examination of the otolaryngologist, auditory function test, and geriatric assessment of neuropsychological status. Two groups were allocated based upon the study of the hearing function: the main group, which included 58 people with moderate hearing loss, and the control group, which included 52 people with significant hearing loss. Results. It was revealed that hearing loss has a negative influence on the cognitive abilities of geriatric patients. With increasing degrees of hearing loss, the progression of dementia is observed. There is a direct correlation between the progression of hearing loss and development of depression in geriatric patients. Conclusion. Our study revealed a relationship between the degree of hearing loss and neuropsychological changes in geriatric patients. Hearing function test as a part of comprehensive geriatric assessment would facilitate the understanding of the causes of neuropsychological disorders in geriatric patients.
DYNAMICS OF MORPHOLOGICAL CHANGES IN BRACHIOCEPHALIC TRUNK ARTERIES INFLUENCED OF ATORVASTATIN THERAPY IN PATIENTS OF HIGH RISK
Authors: Rubanenko OA A
Published: October 2020

Aim - to assess the morphological changes in the extracranial arteries of the brachiocephalic trunk in high-risk patients during atorvastatin therapy. Materials and methods. The study included 78 patients with a high risk of death from cardiovascular disease (mean age 54.8 ± 4.4 years), according to SCORE > 5% and
SIMULTANEOUS OPERATIONS TACTICS IN PATIENTS WITH VENTRAL HERNIAS
Authors: Fedorin A I , Belokonev V I , Pushkin S Yu , Kovaleva Z V , Pushkina D S
Published: October 2020

Objectives - to improve treatment results in patients with ventral hernia and the concurrent surgical diseases by means of the designed surgery tactics. Material and methods. The treatment of 834 patients with ventral hernia, aged from 18 up to 82 years, was analyzed. The group consisted of 196 men (23.5%) and 638 women (76.5%). According to the European Hernia Society (EHS) classification of postoperative ventral hernias the gate types were distributed in patients as follows: W1 - in 132 patients (15.8%), W2 - in 397 (47.6%), W3 - in 305 (36.6%), in 243 (29.1%) cases the hernias were recurrent. 394 (47.2%) patients had 597 simultaneous interventions. The treatment tactics for the patients with hernias and associated diseases was defined according to the designed classification. For the abdominal wall repair the 2 variants of the "tension-free" mesh repair technique were used. Results. Forced simultaneous interventions were performed in 34 patients when the intestinal loops adherent to the scar were situated in the hernia sac. In 27 cases the postoperative ventral hernia was combined to the intestinal fistulas, located out of the hernia area. 12 patients underwent herniolaparotomy conditioned by the intra-abdominal intestinal fistulas closure and small hernias size. To prevent the compartment syndrome in 3 patients with splanchnoptosis the right part of the colon was resected. 103 patients had the planned simultaneous operations including the laparoscopic cholecystectomy in 19 cases, 114 patients underwent the panniculectomy. The preventional appendectomy was performed in patients with the recurrent large hernias. In 140 cases the omentum resection was done due to the signs of the chronical strangulation and omentitis. Postoperative pulmonary artery thromboembolia was the death cause for 3 (0.4%) patients. Only 8 (0.9%) patients suffered the partial hernia recurrence. Conclusion. In patients with hernias the simultaneous operations are conditioned by the pathogenesis and do not affect the severity and frequency of wound complications in the postoperative period. A condition for the simultaneous interventions in patients with hernias is the necessary implementation of the combined techniques of the ventral tension-free mesh hernioplasty.
NEW CLINICALLY RELEVANT BIOCHEMICAL AND FUNCTIONAL MARKERS IN NEONATOLOGY
Authors: Zakharova Lyudmila I. , Pechkurov Dmitrii V. , Poretskova Galina Yu. , Koltsova Nadezhda S.
Published: October 2020

Objectives - to identify the markers of liver functional maturation, the dynamics of the cyclic nucleotide in blood plasma, the indicators of cerebral hemodynamics in premature infants during the early and late neonatal periods. Material and methods. The study included 330 premature infants of 26th - 37th weeks of gestation, examined in early and late neonatal periods. There were 3 groups profiled according to the type of leading pathology - respiratory distress syndrome (RDS) (group I, included 80 children), newborn jaundice and edema syndrome (group II, included 80 children), intraventricular hemorrhage Grade1 (IVH Grade1) (group III, consisted of 46 children). The groups in the study were matched by 3 comparison groups of 124 healthy preterm infants. Results. The clinical significance of the first assayed quantitative indicators of AFP, serum albumin system, cyclic nucleotides, plasma fibronectin in conditionally healthy children of different gestation periods is discussed. The scientific credence was given to pathogenetic role of deviations of these indicators in the development of RDS (the decrease in cAMP, the increase in cGMP, the decrease in ratio cAMP/cGMP); in jaundice and edema syndromes (the increased AFP, the reduction in effective serum albumin concentration (EAC) and overall serum albumin concentration (OAC)), IVH grade 1 (the reduction of plasma fibronectin, and the blood flow speed in vein of Galen according to neurosonography with with Doppler measurements (NSDG) in the first days of life).
Specifity of complex sensory-motor reaction to relevant stimuli in personalized virtual reality in young people
Authors: Segreeva M. S , Korovina E. S , Romanchuk N. P , Alexseeva A. S , Zakharov A. V , Pyatin V. F
Published: October 2020

Objectives - to evaluate the latent period of complex sensory-motor reaction ^SMR) to relevant visual stimuli in virtual reality (VR) with personalized and indifferent content. Material and methods. The study included 10 healthy right-handed males aged 18-19. The selection of subjects in groups was based on two VR scenarios, the content of which reflected (personalized VR) or did not reflect their personal experience (indifferent VR). The latent period of CSMR to relevant visual stimuli was registered using a gamepad and an EEG recording system (BP-010302 BrainAmp Standart 128) in the oddball paradigm. VR scenarios were demonstrated using Oculus Rift CV1 headset. Registration of СSMR in personalized and indifferent VRs was done in three sessions with the interval of 24 hours. Each session lasted 7-8 minutes and included 30-40 CSMR registrations. Igroup Presence Questionnaire (IPQ) was used for subjective evaluation of VR immersiveness. The collected data was processed with IBM SPSS Statistics 22 software. Results. Statistically significant correlations were registered only in VR with personalized content, between the latent time of CSMR and indexes of spatial presence (0.694522) and a general effect of VR immersiveness (-0.592243). It was noted that latent period of CSMR to relevant visual stimuli in VR is determined by the semantic content: the time of CSMR to relevant stimuli in personalized VR was significantly less, than to those in indifferent VR. Conclusion. We support the adequacy of the methodology of studying the mechanisms of human voluntary attention with inclusion of personalized scenes in VR content. It is suggested that such methodology is promising for neurorehabilitation of patients with age-related cognitive impairment
Free hemoglobin reference intervals detected with hemoglobin-cyanide method on a biochemical automatic analyzer ILAB 300 PLUS
Authors: Murygina Olga I. , Zhukova Elena R. , Petrova Olga V. , Nikulina Dina M.
Published: October 2020

Objectives - to evaluate the reference intervals for free hemoglobin concentration with the help of hemoglobin-cyanide method and a biochemical automatic analyzer. Material and methods. The reference group consisted of 120 healthy men and 120 healthy women from the Astrakhan region aged from 20 to 60 years. The fulfilment of standard procedures during the pre-analytical prelaboratory, pre-analytical laboratory, analytical and post-analytical stages of the study ensured the quality control for free hemoglobin evaluation. Blood samples were taken with cubital vein puncture after applying a tourniquet (for not more than 1 minute), patient in lying position, using two-component blood sampling systems - disposable polypropylene tubes with a blood coagulation activator (Sarstedt, Germany). To obtain blood serum, blood tubes were centrifuged at 2500 rpm during 10 minutes. The free hemoglobin in blood serum was detected by the hemoglobin-cyanide method using a ILAB 300 PLUS biochemical automatic analyzer (Laboratory Instrumentation, USA). The data was processed using the software package Statistica 6.0 for Windows (StatSoft Inc, США). Results. We used the classical approach and followed the strict inclusion and exclusion criteria, recommended by CLSI C 28-A3 guidelines. Gender and age differences in the content of free hemoglobin in blood serum in men and women of the Astrakhan region were not found. The reference interval of free hemoglobin in men and women of the Astrakhan region was evaluated as 0.02-0.84 g/l.
Influence of some of occupational factors on the course of psoriasis in men and women
Authors: Mukhamadeeva O. R , Sharafutdinova N. H
Published: October 2020

Objectives - to study the influence of workplace factors affecting the course of psoriasis in men and women in Ufa. Material and methods. 630 patients were assessed for the level of social status, level of education, types of work, the presence of harmful factors, the frequency of requests for medical care, the clinical severity according to Psoriasis Area Severity Index (PASI), the Dermatology Life Quality Index (DLQI), the level of anxiety and depression on the HADS scale. Results. Among the negative factors that influence the course of the disease, men more often than women noted excessive physical activity, while women more often than men noted hypothermia, noise, chemicals, twice as often vibration and shift work. The same number of respondents of both sexes identified stress and hypodynamia as the leading factors. Women noted the negative influence of the stress factor on the course of psoriasis more distinctly than men (average score 3.9±0.2 and 2.8±0.3, accordingly). The level of anxiety was significantly higher in women (7.5± 1.4) than in men (5.7±0.6), while the coefficient of variation in men is one and a half times higher than in women. Conclusion. It is necessary to plan activities aimed at reducing the level of occupational stress and increasing resistance to stress in women with psoriasis and optimize physical activity to reduce its negative impact on men with psoriasis, and optimize physical activity to reduce its negative impact on men with psoriasis. A deeper study of triggers in all areas of life, that have a negative impact on the course of the disease, should be continued. The complex action on the triggers through preventive measures will help to increase the effectiveness of drug treatment and improve the quality of life of patients with psoriasis.