bluuebunny/crossref_metadata_2025 huggingface dataset:
Muscle invasive bladder cancer treatment selection in an emerging treatment era: A patient preference study.
Authors: Smith Angela , Gore John L. , Chisolm Stephanie , Squires Patrick , Li Haojie , Franco Sonia , Vass Caroline , Liu Xiaoying , Mansfield Carol
Published: February 2025

753

Background:
Patients with muscle invasive bladder cancer (MIBC) face a preference-sensitive choice among various treatment alternatives. MIBC is typically treated with radical cystectomy (RC) or bladder-sparing chemoradiation, but systemic therapy also plays a conjunctive role in reducing recurrence rates. This study elicited preferences for available and emerging systemic treatments among MIBC patients in the United States.
Methods:
Patients with self-reported MIBC participated in an online survey. A discrete-choice experiment elicited preferences for attributes of existing and emerging systemic treatments that could be administered with either RC or bladder-sparing approaches. Evidence-based attributes (and levels) included timing and duration of therapy (3 months before and/or 9-12 months after primary treatment); time in delaying cancer recurrence (20-64 months); overall survival (OS) rate at 5 years (40%-85%); chance of treatment-related adverse events (AEs), including fatigue (from none to moderate-severe), neuropathy (from none to moderate-severe), and risk of immune-related AEs that require oral steroid treatment (0%-25%). Conditional relative importance of attributes and risk tolerance were calculated from random-parameters logit models. In addition, direct-elicitation questions offered choices between fixed profiles of bladder-sparing treatment and RC with adjuvant and neoadjuvant systemic treatments. The Shared Decision Making (SDM) Questionnaire (SDM-Q-9) was also included, revealing patients’ levels of satisfaction with previous real-world choices. Responses to the fixed-profile questions and SDM-Q-9 were analyzed descriptively.
Results:
202 participants completed the survey. Of the treatment attributes and levels evaluated, improvements in efficacy were most important (OS at 5 years, followed by delaying cancer recurrence). The average patient was tolerant of AEs and willing to accept high levels of risks (greater than those presented in the survey) and severity for any of the OS improvements offered. Two-thirds of respondents (66.8%) preferred RC plus neo- and adjuvant intravenous treatment in a profile with a 25-percentage-point increase in OS at 5 years, a 40-month delay in recurrence, and a 15% risk of immune-related AEs, mild fatigue, and nerve damage over a bladder-preserving treatment with chemoradiation and no AEs. Almost 20% of respondents disagreed with the statement “My doctor asked me which treatment option I prefer” when reflecting on their SDM experiences.
Conclusions:
Improving OS and delaying recurrence were the most important attributes to patients in this sample, and patients were willing to accept clinically relevant treatment-related AEs for the improvements in efficacy. Patients demonstrated heterogeneous preferences; efforts to promote shared decision-making are therefore warranted.
Non-muscle invasive bladder cancer treatment selection in an emerging treatment era: A patient preference study.
Authors: Smith Angela , Gore John L. , Chisolm Stephanie , Squires Patrick , Li Haojie , Dave Hema Kishore , Vass Caroline , Liu Xiaoying , Mansfield Carol
Published: February 2025

754

Background:
Patients with non-muscle invasive bladder cancer (NMIBC) who become unresponsive to Bacillus Calmette-Guérin (BCG) face preference-sensitive choices between emerging and established bladder-sparing treatments or radical cystectomy (RC). This study elicited 1) the preferences of patients in the United States for bladder-sparing treatments with different benefits and burdens and 2) their choice between these options and RC.
Methods:
Patients with self-reported NMIBC and BCG experience completed an online survey. A discrete-choice experiment (DCE) elicited preferences for hypothetical bladder-sparing treatments. Evidence-based treatment attributes (and levels) included chance of recurrence of NMIBC (45%-69%) and chance of progression to MIBC 1 year after treatment (2%-30%); administration burden (intravesical every week depending on response or every 3 months for 1 year, or intravenous every 6 weeks for up to 2 years); treatment-related fatigue (none to moderate-severe); chance of discomfort and pain or urinary tract infection (0%-30%); and chance of developing immune-related adverse events (AEs) (0%-25%). Conditional relative importance of attributes and risk tolerance measures were calculated from random parameter logit models. In addition to the DCE, direct-elicitation questions offered choices between fixed profiles of different bladder-sparing treatments and RC. The Shared Decision Making (SDM) Questionnaire (SDM-Q-9) revealed patients’ levels of satisfaction with previous real-world choices. Responses to the fixed-profile questions and SDM-Q-9 were analyzed descriptively.
Results:
Among the 206 respondents, reduced risks of progression and disease recurrence were the most important attributes given the range of levels included in the DCE. The other attributes—treatment-related AEs and administration burden—were less important and had statistically similar impacts on choices. On average, patients were willing to accept a >25% risk of immune-related side effects requiring oral steroids to achieve the greatest reductions in disease progression and recurrence offered in the survey. With the exception of repeated BCG-like therapy, most patients (>70%) preferred bladder-sparing treatments over RC. Over 25% of respondents disagreed with the statement “My doctor asked me which treatment option I prefer” when reflecting on their SDM experiences.
Conclusions:
Patients with NMIBC cared most about treatment efficacy and were generally willing to accept clinically relevant levels of treatment-related risks and discomfort to achieve reductions in disease progression and recurrence. Patients demonstrate heterogeneous preferences, and continued efforts to incorporate shared decision-making into treatment decisions are warranted.
Patient satisfaction with geriatric and functional assessments and referral to frailty-related interventions among older adults presenting to the University of Colorado Urologic Oncology Multidisciplinary Clinic.
Authors: Ahmed Mohamoud , Mantha Aditya , Lakritz Stephanie , Konig Franchesca , Kessler Elizabeth R.
Published: February 2025

TPS273

Background:
Geriatric assessments (GA) are valuable tools for determining the functional age of patients and represent the standard of care in evaluating vulnerabilities in older adults with cancer. In oncological treatment, these assessments can help refer patients to appropriate ancillary resources, such as physical therapists, registered dietitians, and social workers, while also assisting in selecting chemotherapy regimens, surgical interventions, and radiation therapy plans. GA and GA-guided management have been shown to positively impact treatment completion and reduce chemotherapy-related toxicity in two recent randomized clinical trials. However, there is minimal data assessing patient satisfaction with the interventions provided through this assessment. This study aims to evaluate patient experiences and acceptance of GA and fragility-based referrals recommended by GA, while also identifying patient-reported barriers to accessing these referred resources. Understanding patient acceptability towards geriatric and functional assessments, along with the determinants and barriers to referral completion, can provide additional information to improve oncologic care for older patients.
Methods:
This is a single-center feasibility study enrolling patients aged 65 and older who are diagnosed with genitourinary cancer and present to the University of Colorado Urologic Oncology multi-disciplinary conference (MDC). The primary endpoint is the patient-reported acceptability of incorporating geriatric and functional assessments. The secondary endpoint is patient-reported determinants and barriers to completing appropriate referrals based on findings from the GA. Patients will undergo a Practical Geriatric Assessment (PGA) and a Stopping Elderly Accidents, Deaths, and Injuries (STEADi) assessment. Based on their functional score, patients will be referred to Cancer Rehabilitation Medicine, physical therapy, occupational therapy, or the BfitBwell exercise program. Additionally, if the patient’s weight has decreased by more than 3 kilograms in the 3 months prior to their visit, they will be referred for nutritional support. Patients will also be referred to social services if they report significant concerns regarding their ability to manage daily living activities or if they lack adequate social support. Patient acceptability will be collected using validated acceptability of intervention surveys. Semi-structured qualitative interviews will be conducted 8 weeks after the patient’s MDC visit, focusing on patient-reported determinants and barriers to completing fragility-related referrals.
The effect of circadian rhythm–based medication timing adjustments on the efficacy and safety of novel hormonal therapy.
Authors: Zhao Junliang , Zhao Diwei , Li Yuanwei , Cai Xinyang , Yang Zhenyu , Zhou Fangjian , Li Yonghong , Wang Jun
Published: February 2025

TPS277

Background:
Neoadjuvant hormonal therapy (NHT) serves as the primary treatment approach for metastatic hormone-sensitive prostate cancer (mHSPC) by either inhibiting androgen synthesis or blocking androgen receptor binding, thereby suppressing tumor growth. Despite its effectiveness, patients with mHSPC inevitably develop resistance to NHT over time, advancing to metastatic castration-resistant prostate cancer (mCRPC), which is associated with a poor prognosis. Androgen synthesis and secretion exhibit a prominent circadian rhythm, with accelerated synthesis in the early morning, peaking around 8:00 AM, followed by a decline to nadir by approximately 8:00 PM. Administrating NHT agents during nighttime may enhance therapeutic efficacy by preemptively inhibiting androgen synthesis and receptor binding before the peak secretion period. Consequently, we have designed a prospective study to evaluate and compare the efficacy and safety of daytime versus nighttime administration of NHT agents in patients with mHSPC.
Methods:
This prospective, open-label, phase II study will enroll 70 patients with mHSPC. Key eligibility criteria include histologically or pathologically confirmed prostate cancer, classified as mHSPC, without prior NHT or chemotherapy. Patients currently receiving other systemic antitumor therapies, those who have undergone organ transplantation within the past 3 months, or been diagnosed with autoimmune disease will be excluded. Eligible patients will be randomized in a 1:1 ratio to receive NHT agents either between 7:00 and 9:00 AM or between 10:00 and 12:00 PM. Treatment is continued until disease progression. The primary objective is to evaluate the effect of nighttime administration of NHT agents by assessing PSA response rate (PSA-RR), defined as the proportion of patients achieving > 90% reduction in PSA from baseline after 3 months of NHT. Secondary endpoints include circulating tumor cell (CTC) clearance rate, clinical benefit rate, objective response rate (ORR), duration of response (DoR), time to objective response, radiographic progression-free survival (rPFS), overall survival (OS), and treatment-emergent adverse events (TEAEs). Differences in response rates between the 2 groups will be analyzed using the Chi-square test. Survival endpoints will be estimated using the Kaplan-Meier method, with between-group comparisons conducted by the log-rank test. Currently, 14 of a planned total of 70 participants have been enrolled. Clinical trial information:
NCT06505278
.
Ccn2a acts downstream of cx43 to influence joint formation during zebrafish fin regeneration
Authors: Hyland Victoria , Iovine M. Kathryn
Published: February 2025

This study provides new insights into the molecular pathways dictating skeletal patterning during zebrafish fin regeneration. Connexin43 (Cx43) is known to influence skeletal patterning by inhibiting evx1 expression and thereby regulating the timing of joint formation. Here, we demonstrate that cellular communication network factor 2 (ccn2a) also contributes to this pathway. We find that Ccn2a appears to act downstream of Cx43 and similarly inhibits joint formation by inhibiting evx1 expression. Pharmacological inhibition of β-catenin demonstrates that ccn2a is likely regulated by β-catenin. Additionally, this paper provides evidence that Yap signaling contributes to joint formation through regulating ccn2a. These findings provide novel insights into the role of Ccn2a during skeletal patterning.
Khdrbs1 drives re-differentiation of bipotential progenitor cells by inhibiting p53 in zebrafish biliary-mediated liver regeneration
Authors: Gang Kai , Chen Qi , Sun Junhui , Zhang Tingwei , Cai Pengcheng , Ni Rui , Ma Jianlong
Published: February 2025

After severe liver injury, biliary epithelial cells (BECs) undergo de-differentiation into bipotential progenitor cells (BPPCs), which subsequently re-differentiate into nascent hepatocytes and BECs to accomplish liver regeneration. However, the crucial factors governing the re-differentiation process of BPPCs remain largely unknown. Here, using a zebrafish model of severe liver injury, we observed specific expression of khdrbs1a and khdrbs1b (collectively known as khdrbs1) in BPPCs through single-cell RNA analyses and fluorescence in situ hybridization. Subsequently, to eliminate the genetic compensation, we generated a CRISPR/dead Cas9-mediated system for interfering with khdrbs1 in BECs, which caused defective liver regeneration and impaired re-differentiation of BPPCs. Furthermore, the khdrbs1−/− mutant displayed impaired proliferation and re-differentiation of BPPCs during liver regeneration. Mechanistically, p53 signaling was activated in response to the loss of khdrbs1, and tp53 mutation partially rescued the defective liver regeneration of the khdrbs1−/− mutant. In summary, we conclude that Khdrbs1 promotes the re-differentiation of BPPCs in part by inhibiting p53 activation during biliary-mediated liver regeneration in zebrafish.
Σύγχρονες θεωρίες επικοινωνίας και επικοινωνιακή θεολογία
Authors: Ανάσης Ελευθέριος
Published: February 2025

Ἡ προσωπική, κοινωνική, μυστηριακή, λατρευτική, παιδαγωγική, εἰκονολογική καί ἐσχατολογική διάσταση τῆς ἐπικοινωνίας τοῦ Ποιμένος - Ἱερέως, ἡ ὁποία ἀποτελεῖ ὀντολογική προβολή τῆς ὒψιστης προπτωτικῆς κοινωνίας Θεοῦ - ἀνθρώπου ὃπως αὐτή ἐκφράζεται στήν ἐπικοινωνιακή θεολογία τῆς ὁποίας ὀντολογική βάση ἀποτελεῖ ἡ μοναδικότητα τοῦ προσώπου, ὃπως αὐτή πραγματώνεται στόν σύγχρονο ἐνοριακό χῶρο, σέ ἀντίθεση μέ τίς ψευδεπίγραφες ἀνθρώπινης ἐπινόησης ἐπικοινωνιακές θεωρίες οἱ ὁποίες χαρακτηρίζονται ἀπό τή χρησιμοποίηση τοῦ ἀποδέκτη ὡς μέσο μετάδοσης κατευθυνόμενων ἰδεολογιῶν, τήν ἀδιάσπαστη συνένωση καταδυναστευτικῆς ἐπιρροῆς μέσου – θεατή, τόν οἰκονομικό συσχετισμό καί τήν μαζοποίηση τοῦ προσώπου.
Selling Data to Marketers
Authors: Guo Liang
Published: February 2025

The supply and the demand for data analytics are growing rapidly. Recent years have seen a surge in the availability of massive consumer data and in the emergence of data sellers (e.g., brokers and intermediaries). Unlike standard products, the value of data analytics for marketers depends on how their business decisions can be enabled and improved. In this paper, we investigate how a monopoly seller can offer a menu of data-based service plans to screen heterogenous marketers that can decide whether to take an action (e.g., direct selling, targeting, lending) with uncertain value and privately known cost. We characterize how, and for which marketers, the provision of information may be distorted in the optimal design. We present conditions under which optimally supplied information can be socially excessive or insufficient. It is shown that selling data appends may yield double reversals in the optimal service plans, in comparison with those when the seller’s offerings serve as marketing lists (i.e., the action is infeasible under the marketers’ outside option). We articulate how these results are coherently driven by the same underlying mechanism regarding how the marginal value of information is endogenously derived from the improvement in the marketers’ decision making over their default action. We also examine how our results can be enriched in alternative settings on the production and the costs of information.

This paper was accepted by Dmitri Kuksov, marketing.
Dermatological assessment: history-taking and examination
Authors: Alsararatee Hasan H
Published: February 2025

Nurses of all disciplines will find dermatological complaints one of the most common presentations in their practice. This article looks at effective techniques when assessing dermatological conditions.

Skin problems are common, affecting up to one-third of the population during their lifetime, and they are frequently encountered by advanced clinical practitioners (ACPs) in both primary and secondary care settings. Despite the prevalence of dermatological presentations, ACPs often feel unprepared to conduct a thorough dermatological history and examination. This article aims to provide guidance to trainees and qualified ACPs, whether in acute hospital settings or primary care, to perform dermatological assessments and examinations systematically. This is the first article in a two-part series on dermatological assessment.
Arqueologia d’un monestir Prepirinenc a Catalunya, dels visigots a la implantació del feudalisme a Santa Cecília dels Altimiris
Authors: Alegría Tejedor Walter
Published: February 2025

A la serra del Montsec es localitza el jaciment arqueològic dels Altimiris. Aquest té els seus inicis a la Cova Colomera a mitjans del segle V i està relacionat amb la necròpolis propera dels segles V-VII de Sant Martí de les Tombetes. Els Altimiris s’ocuparà a finals del segle V per una societat cristiana i romana que esdevindrà una comunitat monàstica durant els segles VI i VII. L’expansió musulmana del s. VIII provocarà l’abandonament parcial de l’assentament fins que serà reocupat al segle IX, per una societat influenciada pels carolingis, fins el seu abandonament al segle XI. La troballa i estudi d’aquest jaciment ha permès assentar unes bases històriques i arqueològiques respecte el desenvolupament de comunitats cristianes als Pirineus i Prepirineus Occidentals Catalans.
Monasteries Established in Roman Villas: The Case of Torre de Palma (Portugal)
Authors: Maloney Stephanie J.
Published: February 2025

Torre de Palma is the site of a large Roman villa founded in the first century CE. It was enlarged and modified over the following six centuries. The southern half of the site includes residential and agricultural structures traditionally associated with rural villas of the period. The northern section of the site includes a religious complex, two cemeteries and two, or possibly three, additional buildings. The church, built over the remains of a Roman temple, was founded in the late fourth or early fifth century, rebuilt in the sixth and modified in the seventh. Baptismal fonts belonging to all three phases of construction, and functioning simultaneously, suggests baptism was especially important at Torre de Palma and might have attracted pilgrims. Probably, someone had to take care of the church once the villa was abandoned in the fifth century. In this paper, it is proposed that a monastic community fulfilled that function.
LA TRADUCCIÓN ITALIANO-ESPAÑOL DE VERBOS SINTAGMÁTICOS DE MOVIMIENTO EN LA LITERATURA CONTEMPORÁNEA: EL CASO DE LOS LEONES DE SICILIA
Authors: Florio Nicola
Published: February 2025

Los verbos sintagmáticos, también conocidos como construcciones verbo-partícula, son un recurso lingüístico muy frecuente en las lenguas de marco satélite, que tienden a lexicalizar el componente semántico de Manera en la raíz verbal y la Trayectoria a través de partículas postverbales en la construcción de eventos de movimiento. Sin embargo, la lengua italiana representa una excepción muy interesante en el patrón de lexicalización preferente del grupo de las lenguas románicas, englobadas en la categoría de las lenguas de marco verbal, puesto que los verbos sintagmáticos no solo gozan de gran presencia en italiano, sino que, además, su frecuencia de uso es cada vez mayor. En este artículo se presenta un estudio centrado en los verbos sintagmáticos de movimiento, compuestos por un verbo de movimiento y una partícula postverbal, de manera comparada entre dos lenguas consideradas afines como el italiano y el español. Se analiza la presencia, estructura y uso de este tipo de construcciones sintagmáticas desde el enfoque de la Lingüística Cognitiva y a partir de un corpus textual paralelo en italiano y español compuesto por la novela original italiana I leoni di Sicilia, de Stefania Auci, y su traducción al español Los leones de Sicilia, por César Palma Hunt. El objetivo fundamental consiste en identificar los verbos sintagmáticos de movimiento presentes en el texto original italiano y compararlos con las estructuras lingüísticas utilizadas en la traducción en español, para observar las preferencias mostradas en ambas lenguas en la expresión del movimiento e identificar las técnicas de traducción utilizadas para trasladar estas estructuras sintagmáticas de movimiento al texto en español. Los datos obtenidos nos permiten reflexionar sobre el efecto que las técnicas de traducción empleadas tienen en el texto literario final al intentar compensar las diferencias en los recursos lingüísticos disponibles en ambas lenguas, así como anticipar posibles dificultades que tendrán que afrontar los traductores de textos literarios entre italiano y español ante la presencia de verbos sintagmáticos de movimiento.
San Marco in the Muck: Goethe's Venetian Epigrams and the Poetry of Emergent Form
Authors: Schutjer Karin
Published: February 2025

abstract: Goethe's Venetian Epigrams (1790/1795) takes off from a mood of artistic, social, and political crisis, calls upon Goethe's own morphological investigations, and positions itself at the poetic boundary. Binding together this seemingly disparate collection is Goethe's fascination with form, including the representational affordances of the epigram itself. The central question is this: How can the artist shape the world while remaining true to it, thereby fostering rather than disfiguring emergent forms? The cycle unfolds an epigrammatic ethos of encounter, a mode of interaction that represents an alternative to the varieties of violent imposition to which the poet also bears witness.
Mechanism analysis of 2 µm thulium-doped picosecond laser ablation on myocardial tissue in minimizing thermal injury
Authors: Cao Siyuan , Zhao He , Xia Tong , Liu Ang , Pan Shengli , Zhang Qian , Wang Xiuhong , Yan Chaowu , Wang Pu
Published: February 2025

In this work, we introduced a fully fiber-integrated 2 µm thulium-doped laser system and conducted parametric analysis and mechanism studies on myocardial tissue ablation using this laser. Fresh porcine myocardial tissue served as the model, allowing precise adjustment of laser power (1.0-3.0 W) and scanning speed (1-2.5 mm/s). Ablation experiments were conducted under controlled conditions, assessing ablation morphology, thermal damage, element distribution, chemical composition, and pathology. Finite element models for temperature fields and ablation theory were established. Simulation results indicated a significant influence of laser parameters on ablation outcomes. Controllable ablation was achieved by adjusting parameters. Experimental results showed a maximum ablation depth of 0.55 mm, an ablation area of 4.07 mm2, and a minimal thermal damage area of 1.02 mm2. This study provides insights into parameter optimization and ablation mechanisms, confirming the potential of a 2 µm thulium-doped picosecond laser for precise and minimally invasive cardiac interventions.
Differentiable design of progressive-addition lens using NURBS surface
Authors: Pan Xinghua , Tang Haisong , Feng ZeXin , Xiang Huazhong
Published: February 2025

Presbyopia is an age-related condition that gradually reduces the eye’s ability to focus on nearby objects, affecting over a billion people globally. The progressive-addition lens (PAL), commonly used for presbyopia correction, struggles to eliminate inherent astigmatism in the lateral areas of the progressive corridor. In this paper, we propose an efficient method for designing PAL using a differentiable optimization approach based on non-uniform rational B-spline (NURBS) surface, with an initial estimate derived through a modified variational-difference numerical method. Our method focuses on addressing a nonlinear error function without local approximations. In the two design examples, the high-level astigmatism areas near the intermediate transition zone are pushed toward the edge of the lens, demonstrating the effectiveness of our method.
Monolithic Er:YAG ceramic waveguide laser fabricated by femtosecond direct laser writing
Authors: Sumiya Taishi , Tani Shuntaro , Tsunoda Akihiro , Nakazaki Masato , Kobayashi Yohei
Published: February 2025

We demonstrated a monolithic waveguide laser in Er:YAG ceramics fabricated using femtosecond direct laser writing. High-quality Er:YAG ceramics with precisely controlled Er-ion doping were synthesized, providing an optimal medium for laser and amplifier applications. Waveguide structures were inscribed within the ceramics to support low-loss propagation with a large mode area. A monolithic laser cavity was formed by applying dielectric multilayer coatings to the waveguide facets. The waveguide laser, pumped at a wavelength of 1532 nm, achieved 82 mW output and 27% slope efficiency at a wavelength of 1645 nm. Single-longitudinal-mode operation was achieved at 11 mW.
Design of an ultra-wideband low-loss miniaturized 3 dB coupler
Authors: Hou Donglian , Fu Haihao , Guo Yuying , Gao Wei , Wang Xin , Lou Shuqin
Published: February 2025

A novel ultra-wideband low-loss miniaturized 3 dB coupler based on a polymer dual-hollow-core anti-resonant fiber (DHC-ARF) is proposed. The wavelength dependence can be effectively reduced by adopting two identical elliptical cores in the DHC-ARF and the polarization dependence can be greatly weakened by introducing two small nested tubes into two cladding tubes at both sides of the air-gap channel between two cores. The 3 dB coupler can be constructed by a 4.92 mm long DHC-ARF with an extremely low loss of 0.005 dB. An ultra-wide bandwidth as high as 391 nm covering the wavelength range from 1325 nm to 1716 nm can be attained, in which the coupling ratio is stable within 50 ± 2% and the coupling ratio difference is maintained within ±1.77%. The 3 dB coupler based on the DHC-ARF exhibits high performance of an ultra-wide bandwidth, low loss, and miniaturization; thus, it has tremendous application potential in hollow-core fiber application systems.
Study of the polarization locking transmission mechanism during the second harmonic generation
Authors: Huang Jinming , Zhou Pengfei , Li Jianing , Liu Rui , Xie Pengjian , Li Bingxuan , Zhang Ge
Published: February 2025

This study investigates the transmission mechanism of the beat-frequency signal of the fundamental wave during extra-cavity second harmonic generation (SHG) in Nd:YAG laser. By precisely controlling intracavity anisotropic losses, we observe that the beat-frequency signal in the second harmonic had approximately twice the amplitude of the fundamental wave. Furthermore, the output efficiency of the second harmonic is significantly improved. A theoretical model for the transmission of the fundamental wave's beat-frequency signal in the extra-cavity SHG is developed. For the first time, this study reveals the relationship between the beat frequency of the fundamental wave and second harmonic in extra-cavity SHG, both theoretical and experimental. These findings offer valuable insights for designing high-efficiency extra-cavity SHG systems for isotropic lasers.
NAVIP: Unraveling the influence of neighboring small sequence variants on functional impact prediction
Authors: Baasner Jan-Simon , Rempel Andreas , Howard Dakota , Pucker Boas
Published: February 2025

Once a suitable reference sequence has been generated, intra-species variation is often assessed by re-sequencing. Variant calling processes can reveal all differences between strains, accessions, genotypes, or individuals. These variants can be enriched with predictions about their functional implications based on available structural annotations, i.e., gene models. Although these functional impact predictions on a per-variant basis are often accurate, some challenging cases require the simultaneous incorporation of multiple adjacent variants into this prediction process. Examples include neighboring variants which modify each other’s functional impact. The Neighborhood-Aware Variant Impact Predictor (NAVIP) considers all variants within a given protein coding sequence when predicting the effect. As a proof of concept, variants between the Arabidopsis thaliana accessions Columbia-0 and Niederzenz-1 were annotated. NAVIP is freely available on GitHub (https://github.com/bpucker/NAVIP) and accessible through a web server (https://pbb-tools.de).
Perception of gender stereotypes in the intention to undertake in the area of information technology: A qualitative study with undergraduate students at a federal university
Authors: Borges Luana , Ramos Anatália , Ferraz Janaynna
Published: February 2025

The objective The aim of this study is to understand how women in higher education in Information Technology (IT) perceive the influence of gender stereotypes on their intention to undertake their field of activity. Through basic qualitative research, nine semi-structured interviews were conducted with students of the Bachelor's Degree in Information Technology (BTI) at a Brazilian federal university. As an analysis strategy, content analysis was used, in the thematic/categorical modality, with the support of the ATLAS.ti® software. The main results showed that gender stereotypes are common in the IT sector and that the insertion of women in entrepreneurship tends to be affected by this perception. As theoretical contributions, a lack of female self-representation in leadership positions in business was observed, and sexism was perceived as a social problem and a cause of the reported inequalities. The relevance of this article lies in the gap in the literature on female entrepreneurship from the perspective of gender stereotypes, especially in the IT sector. Social contributions to management consist of producing insights into the problem of female entrepreneurship in the IT sector, an area with little empirical research on the subject, which can assist in the development of public policies and initiatives that promote gender equality and the empowerment of women in this field.
Shifting Frontiers across Cinema and Literature
Authors: Karácsonyi Judit
Published: February 2025

Reflections on the relationship between film and literature seem to focus on film adaptations, while the transformation of a film into a novel remains a less known practice. In my paper, I propose to address some of the questions raised by Nathalie Léger’s contemporary literary novelisation, Suite for Barbara Loden. While examining how this type of adaptation establishes an intermedial dialogue between cinema and literature, I intend to explore how the operation of modulation allows the filmic narrative to become more than a simple “mould for the novelistic hypotext”, to become the pre/text for the literature it inspires and within which the film “takes form and finds its reflection”.
Nanomechanical properties of neutron-irradiated concrete
Authors: Libera Ondřej , Němeček Jiří , Halodová Patricie , Hlaváč Zbyněk , Němeček Jiří
Published: February 2025

Concrete exposed to irradiation from nuclear reactor undergoes atomic-level degradation due to the influence of neutrons, secondary gamma rays, and associated gamma heating. The radiationinduced damage decreases the mechanical properties of the concrete and affects its performance as a construction material. The concrete samples analysed in this work were prepared from blended Portland cement CEM II 32.5R mixed with siliceous aggregates with a size of 0–2.5 mm. The material underwent irradiation in the LVR-15 research reactor in Research Centre Rež to the target neutron fluence of 1.6–1.8 · 1019 n cm−2 (E>0.1MeV) and received the gamma dose of ⁓ 500 MGy. The temperatures during irradiation were kept within a range of 50–60 °C. The mechanical properties of the individual phases in the cementitious matrix after neutron irradiation were assessed by the nanoindentation. To track the evolution of the nanomechanical properties of individual components under radiation, a comparison was made between the mechanical properties of neutron-irradiated material and pristine concrete.
On the Choice of the Higher Order DMD Mode Part for Projection to Physical Coordinates
Authors: Belda M. , Hlavatý T. , Isoz M. , Hyhlík T.
Published: February 2025

Higher-order dynamic mode decomposition (HODMD) was proposed as a more robust extension of classical dynamic mode decomposition (DMD) designed to overcome DMD’s main weaknesses, i.e. susceptibility to noise and inability to capture highly non-linear dynamics. In this study, we try to tie up one of the remaining loose ends of the HODMD. Particularly, each HODMD mode comprises multiple parts that can be projected back to the physical coordinates. Consequently, there is an apparent ambiguity in which part of the HODMD mode to select for projection back to physical coordinates. This ambiguity is present even in the most recent literature and is nowhere explained properly. However, we state a lemma, supported by proof, that the choice of the HODMD mode part does not matter. Then, the equivalence of HODMD mode parts is illustrated on a HODMD analysis of a wake behind a cylinder in a crossflow at Re ≈ 5000.
Locally Optimized Virial Equation for CFD Simulations of Real Gas Flows
Authors: Fürst J.
Published: February 2025

The contribution proposes a simple virial-like equation of state (EOS) suitable for CFD simulations of real gas flows through turbines or compressors. The virial coe cients are locally optimized using the idealized isentropic flow through the machine. The resulting equation combined with a simple polynomial t for the ideal part of the heat capacity provides a better approximation of the full EOS than standard cubic EOS such as Aungier-Redlich-Kwong.
Simulation of Compliance in a Human Carotid Artery with Resistance Boundary Conditions
Authors: Richter K. , Probst T. , Hundertmark A.
Published: February 2025

The subject of this study is to model the physiologically realistic volumetric compliance of a human carotid artery within a fluid-structure-interaction (FSI) simulation. Computed Tomography Angiography (CTA) scans of a patient’s carotid artery are used to create a virtual twin geometry of a computational domain for fluid volume and vascular tissue. In vitro silicon replicas are used to validate the stress-strain relationship of the material used and to validate the simulation with laboratory compliance tests. Subsequently, a strain-dependent Young’s modulus is embedded in a high-fidelity vessel simulation to adapt the linear elasticity model to the measured vessel inflation. Resistance outlet boundary conditions are derived in the FSI context and are applied to model the physiological flow and pressure waves. As a result of this study, the natural mechanics of arteries during the cardiac cycle, the Windkessel effect, is observed.
On Dynamics of the Wake Behind a Wall Mounted Finite Length Cylinder
Authors: Uruba V. , Procházka P.
Published: February 2025

Dynamics of the wake behind a finite-length circular cylinder with an aspect ratio 2 is to be studied experimentally. The cylinder, mounted perpendicular to a ground plane, was exposed to a cross-flow with a thin boundary layer developed on the wall. The Reynolds number was 9700. The time-resolved Particle Image Velocimetry technique was used to investigate the dynamics of the wake in two planes parallel to the flow. Particular attention was paid to tip vortices, Kármán-like vortices and arch vortex dynamics in the near wake. Several kinds of vortex streets in the wake were identified and studied.
Imaging Findings of Solitary Fibrous Tumors of the Gallbladder
Authors: Tuan Trinh Anh , Huong Le-Thi Mai , Chau Nguyen Thu Minh , Duy Ngo Quang , Anh Nguyen-Thi Hai , Hung Nguyen Duy , Ceugnart Luc , Duc Nguyen Minh
Published: February 2025

Solitary Fibrous Tumor (SFT) is a rare mesenchymal tumor with a higher incidence of benign than malignant, most common location in the pleura. Although this tumor has been found in other locations in the body such as the head and neck region, retroperitoneal space, and intra-abdominal omentum, SFT of the gallbladder remains extremely rare in the medical literature. In this article, we present the imaging characteristics of Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) of gallbladder SFT, thereby contributing to providing information in the study of this rare pathology.
Analysis of watercourses on Aretin’s Map of the Bohemian Kingdom from 1619
Authors: Čábelka Miroslav , Bayer Tomáš
Published: February 2025

Historic maps provide evidence of landscape development, including the shape of watercourses in the past. Aretin’s map of the Bohemian Kingdom (contemporary Czechia) from 1619 is Bohemia’s third-oldest map. In this analysis of Aretin’s map, we aimed to create an overview of watercourses at the beginning of the 17th century. We used MapAnalyst software to perform cartometric analyses and plotted watercourses on a contemporary map. Special interest was given to watercourses outside of the Bohemian Kingdom, which have not been included in previous analyses of the map. Content, semiotic, and cartometric analyses focusing on watercourses and on changes in the depiction of rivers over the four editions of Aretin’s map were performed to identify and label the previously unnamed rivers.
Programy socjalne rządu Zjednoczonej Prawicy – PR-owy sukces czy szereg niespełnionych obietnic?
Authors: Kuźniarski Jakub
Published: February 2025

Celem artykułu jest przeprowadzenie analizy programów socjalnych wprowadzonych przez rząd Prawa i Sprawiedliwości w Polsce w latach 2015–2023, skupiając się na ich wpływie na zarządzanie ekonomią kraju. Artykuł ocenia, czy implementacja programów socjalnych przyczyniła się do sukcesu w zakresie redukcji ubóstwa i poprawy warunków życia, czy też doprowadziła do powstania nowych wyzwań, takich jak kryzys gospodarczy. Jednym z kluczowych przykładów jest program „500 plus”, który generował ogromne koszty dla kraju, a także był źródłem licznych mitów, takich jak twierdzenie, że kobiety masowo rezygnują z pracy po skorzystaniu z jego benefitów.
Trudne sąsiedztwo. Wybrane aspekty stosunków polsko-białoruskich w latach 1991–2014
Authors: Matysiak Jakub
Published: February 2025

Niniejszy artykuł stanowi próbę uchwycenia i przedstawienia kilku wybranych aspektów stosunków polsko-białoruskich, które w znaczącym stopniu determinowały relacje między państwami w latach 1991–2014. W tekście uwzględniono budowę podstaw wzajemnych relacji polsko-białoruskich, dojście do władzy Alaksandra Łukaszenki i konsolidację jego reżimu, reakcje Polski i Unii Europejskiej na sytuację na Białorusi oraz sukcesy i porażki wspólnych przedsięwzięć (indywidualnych, czy też w ramach OBWE i UE). Szczególną uwagę poświęcono tzw. krytycznemu dialogowi polsko-białoruskiemu.
Legalisation of Pushback Procedure in the Wake of the Belarus-European Union Border Crisis
Authors: Orłowski Bernard
Published: February 2025

The principle of non-refoulement has been a part of international law for decades. Recent states’ practices have come to undermine this rule by engaging in pushback in the face of the migrant crisis. The author examines the legality of the pushback procedure as a part of the self-defence principle or as a new customary international law rule, especially if a state is under a hybrid attack as was in the case of the EU-Belarus border crisis. This article aims to assess the law and policy regarding the pushback procedure in light of a new era of hybrid warfare.
K-pop oraz generacja AI. Południowokoreański przemysł muzyczny w świetle rozwoju sztucznej inteligencji
Authors: Wolna Weronika
Published: February 2025

Technologie określane jako sztuczna inteligencja – AI w istotnym stopniu wpływają na zmiany szeroko rozumianego przemysłu muzycznego w jego wymiarze popkulturowym. Nie inaczej wygląda sytuacja w branży muzycznej w Republice Korei, gdzie K-pop, czyli muzyka popularna, zyskuje coraz większą rozpoznawalność w wymiarze globalnym, a wykorzystanie sztucznej inteligencji odgrywa tutaj kluczową rolę, przyczyniając się do dynamicznego rozwoju tego sektora. Dlatego celem niniejszej pracy jest zbadanie, w jaki sposób rozwój sztucznej inteligencji kształtuje południowokoreański przemysł muzyczny oraz jakie to przyniesie skutki dla przyszłości K-popu. W artykule wykorzystano metodę analizy porównawczej do zestawienia rzeczywistych grup muzycznych z wirtualnymi. Zastosowano także metodę studium przypadku, aby przeanalizować kampanię promocyjną z użyciem aplikacji specjalizujących się w komunikacji między wykonawcami a fanami. Dodatkowo artykuł odnosi się do wyzwań natury społecznej i etycznej związanych z rosnącym wykorzystaniem sztucznej inteligencji.
Charakterystyka wojen arabsko-izraelskich od 1948 roku do chwili obecnej. Wpływ konfliktu na gospodarkę izraelską, regionalną i globalną
Authors: Malendowska Natalia
Published: February 2025

Od kilku dekad kluczową kwestią w dziedzinie bezpieczeństwa i stabilności regionu Bliskiego Wschodu jest konflikt między państwami arabskimi i Izraelem. Poszczególne etapy konfliktu niosły za sobą konsekwencje na wielu płaszczyznach, między innymi dla gospodarek państw arabskich, Izraela oraz w wymiarze globalnym. W niniejszej publikacji autorka dokonała próby charakterystyki wpływu wojen arabsko-izraelskich na sytuacje gospodarcze państw w regionie Bliskiego Wschodu, w Izraelu oraz dla gospodarki światowej.
Event conflation in high stakes testing: a comparison of usage and relationship to writing scores by language types
Authors: Spring Ryan
Published: February 2025

Talmy (1985. Lexicalization patterns: Semantic structure in lexical form. In Timothy Shopen (ed.), Language typology and syntactic description, vol. 3, 36–149. Cambridge, MA: Cambridge University Press, 1991. Path to realization: A typology of event conflation. In Proceedings of the 17th annual meeting of the Berkeley Linguistics Society, 480–519. Berkeley Linguistics Society) introduced the concept of event conflation: that two micro events can be conceptualized and expressed as a single macro event. He proposed a linguistic typology based on ths concept, and second language acquisition studies have suggested that learners whose first language is of a different type than their target language have extra difficulty interpreting and reproducing event conflation in the target language phrases. However, the degree to which using conflation patterns similar to the first language in one’s target language impedes communication is still unclear. To observe the effect of first and second language type mismatches on communicative ability, data was taken from the independent writing task of the TOEFL iBT® Public Use Dataset and the Event Conflation Finder was used to extract and analyze instances of path encoding. Framing tendencies and correlations between these tendencies and rater scores were compared amongst learners whose first languages are often argued to be one of the three major types: satellite-framed, mixed-framed, and verb-framed. I found that only learners with verb-framed first languages exhibited a clear pattern of correlation between typical satellite-framing patterns and rater scores, suggesting that satellite-framed expressions are more difficult for learners whose first language is verb-framed.
Relevance and Rigour with Qualitative Entrepreneurship Research: A Literature-Review Based Discussion
Authors: Leick Birgit , Tuitjer Gesine
Published: February 2025

As qualitative empirical entrepreneurship research is increasingly gaining momentum, and newly emerging research streams are pushing commonly applied methods to their epistemological limits, such entrepreneurship studies often have issues regarding their rigour, because important onto-epistemological aspects, such as the positionality of the researcher in the research process, are not duly considered. At the same time, qualitative empirical entrepreneurship studies are highly popular, implying a high level of their relevance. This conceptual article discusses how scholars may perform relevant qualitative empirical entrepreneurship research rigorously by combining two methods. To this aim, the article discusses important methodological challenges and opportunities for qualitative empirical entrepreneurship research, in general, and, based upon both a discussion of the methods studied and a systematic literature review, compares the utility of the methods for the qualitative empirical toolbox, which widely applies the Gioia protocol. This comparison of methods, including the Gioia protocol, allows conclusions on increasing both the relevance and rigour of qualitative empirical entrepreneurship research.
Assessing the effectiveness of utilizing low-cost inertial measurement unit sensors for producing as-built plans
Authors: Kamel Abdullah
Published: February 2025

As-built mapping using terrestrial sensors is crucial for accurately documenting the final state of building structures. However, conventional methods often face limitations in urban environments, such as obstructions and the need for clear sightlines. This study evaluates the effectiveness of the low-cost Moasure ONE Inertial Measurement Unit sensor for producing as-built plans, addressing challenges associated with traditional surveying methods like total stations. The research investigates the Moasure ONE’s capabilities in terms of cost, time efficiency, flexibility, and productivity, while adhering to the USA Federal Geographic Data Committee and American Society for Photogrammetry and Remote Sensing accuracy standards. The methodology includes a statistical study, data manipulation, georeferencing, and quality assessment using ground control points. Results indicate that Moasure ONE can achieve a horizontal positional accuracy (RMSEH1) of 17.7 cm, aligning with the required tolerances for detailed mapping. The findings suggest that Moasure ONE offers significant advantages over traditional methods, including reduced survey time and increased detail capture, making it a viable alternative for professional surveying tasks in construction and engineering projects.