bluuebunny/crossref_metadata_2025 huggingface dataset:
Knowledge, meaning and identity: Key characteristics of entrepreneurship in cultural and creative industries
Authors: McKelvey Maureen , Lassen Astrid Heidemann
Published: August 2018

This article introduces the Special Issue, “Varieties of entrepreneurship: Exploring whether, how and why cultural and creative entrepreneurship differs from other varieties”. The aim of the Special Issue is to contribute to a more nuanced understanding of how this particular variety of entrepreneurship emerges, is affected and develops over time. We present the three broad topics addressed in the Special Issue—knowledge, meaning and identity—and position them in the wider academic context of understanding value realization through entrepreneurship in the cultural and creative industries. The six articles presented in the Special Issue come from and combine different streams of literatures, yet jointly they gradually develop their own, hopefully complementary, interpretations, which provide inspiration for a promising agenda for further research.
Identification and characterization of transforming growth factor beta‐induced in circulating tumor cell subline from pancreatic cancer cell line
Authors: Sato Taku , Muramatsu Tomoki , Tanabe Minoru , Inazawa Johji
Published: August 2018

Distant metastasis to liver, lung, brain, or bone occurs by circulating tumor cells (CTC). We hypothesized that a subset of CTC had features that are more malignant than tumor cells at the primary site. We established a highly malignant cell line, Panc‐1‐CTC, derived from the human pancreatic cancer cell line Panc‐1 using an in vivo selection method. Panc‐1‐CTC cells showed greater migratory and invasive abilities than its parent cell line in vitro. In addition, Panc‐1‐CTC cells had a higher tumor‐forming ability than parent cells in vivo. To examine whether a difference in malignant phenotypes exists between Panc‐1‐CTC cells and parent cells, we carried out comprehensive gene expression array analysis. As a result, Panc‐1‐CTC significantly expressed transforming growth factor beta‐induced (TGFBI), an extracellular matrix protein, more abundantly than did parent cells. TGFBI is considered to regulate cell adhesion, but its functions remain unclear. In the present study, knockdown of TGFBI reduced cell migration and invasion abilities, whereas overexpression of TGFBI increased both abilities. Moreover, elevated expression of TGFBI was associated with poor prognosis in patients with pancreatic cancer.
Immunoregulatory influence of abundant MFG‐E8 expression by esophageal cancer treated with chemotherapy
Authors: Kanemura Takashi , Miyata Hiroshi , Makino Tomoki , Tanaka Koji , Sugimura Keijiro , Hamada‐Uematsu Mika , Mizote Yu , Uchida Hiroaki , Miyazaki Yasuhiro , Takahashi Tsuyoshi , Kurokawa Yukinori , Yamasaki Makoto , Wada Hisashi , Nakajima Kiyokazu , Takiguchi Shuji , Mori Masaki , Doki Yuichiro , Tahara Hideaki
Published: August 2018

Milk fat globule‐epidermal growth factor factor 8 (MFG‐E8) is secreted from macrophages and is known to induce immunological tolerance mediated by regulatory T cells. However, the roles of the MFG‐E8 that is expressed by cancer cells have not yet been fully examined. Expression of MFG‐E8 was examined using immunohistochemistry in surgical samples from 134 patients with esophageal squamous cell carcinoma. The relationships between MFG‐E8 expression levels and clinicopathological factors, including tumor‐infiltrating lymphocytes, were evaluated. High MFG‐E8 expression was observed in 23.9% of the patients. The patients with tumors highly expressing MFG‐E8 had a significantly higher percentage of neoadjuvant chemotherapy (NAC) history (P < .0001) and shorter relapse‐free survival (P = 0.012) and overall survival (OS; P = .0047). On subgroup analysis, according to NAC history, patients with high MFG‐E8 expression had significantly shorter relapse‐free survival (P = .027) and OS (P = .0039) only when they had been treated with NAC. Furthermore, tumors with high MFG‐E8 expression had a significantly lower ratio of CD8+ T cells/regulatory T cells in tumor‐infiltrating lymphocytes (P = .042) only in the patients treated with NAC, and those with a lower ratio had a shorter OS (P = .026). High MFG‐E8 expression was also found to be an independent prognostic factor in multivariate analysis. The abundant MFG‐E8 expression in esophageal squamous cell carcinoma might have a negative influence on the long‐term survival of patients after chemotherapy by affecting T‐cell regulation in the tumor microenvironment.
Pharmacological andSARanalysis of theLINS01 compounds at the human histamine H1, H2, and H3receptors
Authors: Corrêa Michelle Fidelis , Barbosa Álefe Jhonatas Ramos , Fernandes Gustavo Ariel Borges , Baker Jillian G. , Fernandes João Paulo dos Santos
Published: August 2018

Histamine is a transmitter that activates the four receptors H1R to H4R. The H3R is found in the nervous system as an autoreceptor and heteroreceptor, and controls the release of neurotransmitters, making it a potential drug target for neuropsychiatric conditions. We have previously reported that the 1‐(2,3‐dihydro‐1‐benzofuran‐2‐yl)methylpiperazines (LINS01 compounds) have the selectivity for the H3R over the H4R. Here, we describe their pharmacological properties at the human H1R and H2R in parallel with the H3R, thus providing a full analysis of these compounds as histamine receptor ligands through reporter gene assays. Eight of the nineLINS01 compounds inhibited H3R‐induced histamine responses, but no inhibition of H2R‐induced responses was seen. Three compounds were weakly able to inhibit H1R‐induced responses. No agonist responses were seen to any of the compounds at any receptor.SARanalysis shows that theN‐methyl group improves H3R affinity while theN‐phenyl group is detrimental. The methoxy derivative,LINS01009, had the highest affinity.
Modification of activated carbon with a silane coupling agent under ultrasonic conditions for the advanced treatment of wastewater with dressing chemicals
Authors: Xiao Jin , Yu Bailie , Yuan Jie , Yao Zhen , Zhong Qifan , Zhang Liuyun
Published: August 2018

Fresh activated carbon (FAC) was oxidised by nitric acid and then the silane coupling agent was grafted onto the surface of FAC under ultrasonic conditions to obtain modified activated carbon (MAC). The chemical oxygen demand was used as the main evaluation index in the wastewater. The effects of benzene, aniline, 2‐mercaptobenzothiazole and methylene blue on the adsorption mechanism and performance of FAC prior and postmodification were investigated by different adsorption models. All of them fitted the Langmuir monomolecular adsorption model. The adsorption capacity of MAC was 1.07, 1.12, 1.56 and 0.62 times that of FAC, respectively, which had a better adsorption effect on hydrophobic organic compounds. The maximum adsorption capacity increased due to the existence of competitive adsorption in multicomponent absorption. Texture properties of activated carbon were characterised by scanning electron microscopy, Fourier Transform‐infrared and Brunauer–Emmett–Teller theory, which show that the surface morphology became spongy, and that Si–O–C and Si–O infrared peaks appeared. In addition to the mesopore volume, the specific surface area, pore volume and micropore volume decreased slightly after the modification.
Endoscopic salvage of a duodenal stump leak and surgical transection of the ampulla
Authors: Chan Joey Ho Yi , Teoh Anthony Y. B.
Published: August 2018

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Sex differences in ADHD trajectories across childhood and adolescence
Authors: Murray Aja Louise , Booth Tom , Eisner Manuel , Auyeung Bonnie , Murray George , Ribeaud Denis
Published: August 2018

Previous studies have hinted at sex differences in developmental trajectories in ADHD symptoms; however, little is known about the nature or cause of these differences and their implications for clinical practice. We used growth mixture modelling in a community‐ascertained cohort of n = 1,571 participants to study sex differences in ADHD symptom developmental trajectories across the elementary and secondary school years. Participants were measured at ages 7, 8, 9, 10, 11, 12, 13, and 15. We found that females were more likely to show large symptom increases in early adolescence while males were more likely to show elevated symptoms from childhood. For both males and females, early adolescence represented a period of vulnerability characterized by relatively sudden symptom increases. Females affected by hyperactivity/impulsivity may be more likely to be excluded from diagnosis due to current age of onset criteria. More attention should be paid to early adolescence as a period of risk for hyperactivity/impulsivity symptom onset or worsening.
A MODEL OF ADDICTION AND SOCIAL INTERACTIONS
Authors: Reif Julian
Published: August 2018

Many consumer behaviors are both addictive and social. Understanding how these two phenomena interact informs basic models of human behavior, and matters for policymakers when the behavior is regulated. I develop a new model of demand that incorporates both addiction and social interactions and show that, under certain conditions, social interactions reinforce the effects of addiction. I also show how the dynamics introduced by addiction can solve the pernicious problem of identifying the causal effects of social interactions. I then use the model to illustrate a new and important identification problem for studies of social interactions: existing estimates cannot be used to draw welfare conclusions or even to deduce whether social interactions increase aggregate demand. Finally, I develop a method that allows researchers to distinguish between two common forms of social interactions and draw welfare conclusions. (JEL D11, H20)
Rescue therapies for seizure emergencies: New modes of administration
Authors: Maglalang Patricia D. , Rautiola Davin , Siegel Ronald A. , Fine Jared M. , Hanson Leah R. , Coles Lisa D. , Cloyd James C.
Published: August 2018

A subgroup of patients with drug‐resistant epilepsy have seizure clusters, which are a part of the continuum of seizure emergencies that includes prolonged episodes and status epilepticus. When the patient or caregiver can identify the beginning of a cluster, the condition is amenable to certain treatments, an approach known as rescue therapy. Intravenous drug administration offers the fastest onset of action, but this route is usually not an option because most seizure clusters occur outside of a medical facility. Alternate routes of administration have been used or are proposed including rectal, buccal, intrapulmonary, subcutaneous, intramuscular, and intranasal. The objective of this narrative review is to describe the (1) anatomical, physiologic, and drug physicochemical properties that need to be considered when developing therapies for seizure emergencies and (2) products currently in development. New therapies must consider parameters of Fick's law such as absorptive surface area, blood flow, membrane thickness, and lipid solubility, because these factors affect both rate and extend of absorption. For example, the lung has a 50 000‐fold greater absorptive surface area than that associated with a subcutaneous injection. Lipid solubility is a physicochemical property that influences the absorption rate of small molecule drugs. Among drugs currently used or under development for rescue therapy, allopregnanolone has the greatest lipid solubility at physiologic pH, followed by propofol, midazolam, diazepam, lorazepam, alprazolam, and brivaracetam. However, greater lipid solubility correlates with lower water solubility, complicating formulation of rescue therapies. One approach to overcoming poor aqueous solubility involves the use of a water‐soluble prodrug coadministered with a converting enzyme, which is being explored for the intranasal delivery of diazepam. With advances in seizure prediction technology and the development of drug delivery systems that provide rapid onset of effect, rescue therapies may prevent the occurrence of seizures, thus greatly improving the management of epilepsy.
Prognostic scores in status epilepticus—a critical appraisal
Authors: Yuan Fang , Gao Qiong , Jiang Wen
Published: August 2018

Currently, there are 4 published scales evaluating status epilepticus (SE) prognosis: the Status Epilepticus Severity Score (STESS), the Epidemiology‐based Mortality score in Status Epilepticus (EMSE), the modified STESS (mSTESS), and the Encephalitis Nonconvulsive Status Epilepticus Diazepam Resistence Imaging Tracheal Intubation (END‐IT) score. The first prognostic score published for SE, the STESS, is a simple and practical scale that evaluates patient prognosis upon admission and is used widely to predict the outcome and stratify patients. Another scale, which was developed based on large epidemiologic studies, the EMSE, is more easily adapted to different regions around the world when assessing individual risk and stratifying patients in interventional studies. The mSTESS was created by adding the modified Rankin Scale (mRS) to the STESS, which decreases the ceiling effect and increases the mortality prediction capabilities of the STESS. The END‐IT is the only prognostic scale assessing functional outcome and is comprehensively simple and satisfyingly accurate. Evaluating the limitations of each of these scales aids in the exploration and advancement of SE prognostic scales, thereby facilitating better clinical interventions and scientific research.
Mitochondrial diseases and status epilepticus
Authors: Rahman Shamima
Published: August 2018

This narrative review focuses on the pathophysiology, diagnosis, and management of status epilepticus in the context of primary mitochondrial disease. Epilepsy is common in mitochondrial disease, reported in >20% of adult cases and 40%‐60% of pediatric cohorts. Status epilepticus is less frequently reported and appears to be associated with particular subgroups of mitochondrial disorders, namely defects of the mitochondrial DNA and its maintenance, and disorders of mitochondrial translation and dynamics. Mechanisms underlying mitochondrial status epilepticus are incompletely understood, and may include bioenergetic failure, oxidative stress, immune dysfunction, and impaired mitochondrial dynamics. Treatments tried in mitochondrial status epilepticus include antiepileptic drugs, anesthetic agents, magnesium, high‐dose steroids, immune globulins, vagus nerve stimulation, and surgical procedures, all with variable success. The outcome of mitochondrial status epilepticus is extremely poor, and effective therapeutic options have not been reported. Improved understanding of the mechanisms underpinning mitochondrial status epilepticus is needed in order to develop more effective treatments.
Risk score predictive of mortality in status epilepticus according to a national database
Authors: Tiamkao Somsak , Buranakul Nattakarn , Saybungkla Pawinee , Sirikarn Prapassara , Sawanyawisuth Kittisak ,   of Integrated Epilepsy Research Group
Published: August 2018

Status epilepticus (SE) is a serious neurologic condition with high morbidity and mortality rates. This study aimed to develop and validate a risk score that is predictive of mortality in patients with SE using clinical factors without electrocardiography. The inclusion criteria of this study were all patients diagnosed with SE and treated between 2005 and 2015. We retrospectively searched for eligible patients using the International Classification of Diseases, Tenth Revision (ICD‐10) code for SE (G41) in the national Universal Health Coverage database. The outcome was death at discharge or within 30 days after discharge. Factors‐associated death was analyzed using stepwise logistic regression analysis. Risk scores were developed based on the final logistic regression model. The final model was also validated. There were 10 924 patients used for model development and 10 808 used for model validation. The formula to determine the risk score for SE mortality was 5 × shock + 4 × age over 60 years old + 3.5 × heart diseases + 3 × acute renal failure + 3 × septicemia + 2.5 × central nervous system infection + 2.5 × age 41‐60 years old + 2 × cancer + 2 × chronic renal failure + 1.5 × age 21‐40 years old + 1 × pneumonia + 1 × respiratory failure + 1 × anemia. The risk scores of greater than 4 indicated risk for mortality with a sensitivity of 78.20% and specificity of 75.38%. The area under the receiver‐operating characteristic (ROC) curve for death in the final model was 83.59%. The area under the ROC curve for the model validation group was 83.52%. SE patients who had a risk score of 4 or more were at high risk for death. Physicians should be aware of the high mortality rate in these particular patients.
Complication Burden Index—A tool for comprehensive evaluation of the effect of complications on functional outcome after status epilepticus
Authors: Kämppi Leena , Ritvanen Jaakko , Strbian Daniel , Mustonen Harri , Soinila Seppo
Published: August 2018

Systemic complications are common in status epilepticus. We have no tools to evaluate total burden of complications and its effect on the outcome of status epilepticus. For Complication Burden Index (CBI) a patient is assessed for 13 complication categories: respiratory, cardiovascular, nervous, renal, hepatic, coagulation, gastrointestinal and musculoskeletal systems, electrolyte/acid‐base balance, infection, hypo‐/hyperglycemia, skin/allergic reactions, and mental condition. Maximum CBI is 13. CBI was internally validated in a retrospective cohort of 70 consecutive adult patients with generalized convulsive status epilepticus (GCSE) treated in a tertiary hospital over a period of 2 years. Functional outcome at discharge was defined Poor for Glascow Outcome Scale (GOS) 1‐3 or worse‐than‐baseline condition and Good for GOS >3 or return to baseline condition. Relative risks (RRs) and receiver‐operating characteristic (ROC) ‐curves were calculated to obtain optimal cutoff. Functional outcome was poor in 40% and worse‐than‐baseline in 59%. In‐hospital mortality was 7%. Average CBI was 3.8 (range 0‐10, median 3). Cutoff value predicting poor functional outcome was a CBI >3 (GOS 1‐3 RR 1.84, P = .045, 95% confidence interval [CI 1.01‐3.33; ROC‐AUC [area under the curve] 0.687, P = .008, sensitivity 64%, specificity 61%; worse‐than‐baseline condition RR 1.52, P = .04, 95% CI 1.02‐2.26; ROC‐AUC 0.662, P = .022, sensitivity 56%, specificity 69%). CBI with cutoff >3 and as a continuous variable was associated with GOS1‐3 (P = .046, P = .002) and with worse‐than‐baseline condition (P = .041, P = .004). CBI is a novel tool for comprehensive assessment of status epilepticus complications predicting poor/worse‐than‐baseline functional outcome with cutoff >3.
Etiologies and characteristics of refractory status epilepticus cases in different areas of the world: Results from a global audit
Authors: Ferlisi Monica , Hocker Sara , Trinka Eugen , Shorvon Simon ,   the International Steering Committee of the StEp Audit
Published: August 2018

To describe the demographics, etiologies, types of status epilepticus (SE), and outcomes in people with refractory and super‐refractory SE from around the world, we prospectively collected cases of refractory SE (RSE) treated with continuous intravenous anesthetic drugs in an intensive care unit setting through online questionnaires using “active surveillance.” We collected information about 776 cases of RSE in 50 countries over 4 years. Control of SE was achieved in 74% of the cases. Neurologic outcomes were poor in 41% of patients, and 24% died. Good outcome was associated with younger age and a history of epilepsy. Etiology strongly influenced the outcome. Patients from Asia were younger, more frequently presented with convulsive SE, and were more frequently affected by infectious etiologies when compared with patients from Europe and the Americas. Despite these differences, outcomes were similar in all countries. Demographics of patients with RSE in a global audit are similar to those in prior single center series, providing evidence of generalizability of those studies. Important differences exist among patients with RSE from different regions of the world, but these do not seem to significantly influence patient outcomes.
Intestinal probiotics restore the ecological fitness decline of Bactrocera dorsalis by irradiation
Authors: Cai Zhaohui , Yao Zhichao , Li Yushan , Xi Zhiyong , Bourtzis Kostas , Zhao Zheng , Bai Shuai , Zhang Hongyu
Published: August 2018

The sterile insect technique (SIT) as an eco‐friendly and reliable strategy has been used to control populations of insect pests of agricultural, veterinary and human health importance. Successful applications of SIT rely on the high‐level ecological fitness of sterile males. A suitable and stable gut microbiome can contribute to the ecological fitness of insect by influencing their physiology, biochemistry and development processes. Here, we show that a shift in the gut bacterial composition and structure by sterilizing irradiation, characterized by a decrease in the major gut microbiota community Enterobacteriaceae, an expansion of the minor members (e.g., Bacillaceae) and a higher richness and diversity, is tightly linked to radiation‐induced ecological fitness (male mating competitiveness, flight capacity, survival rate and life span) decline in Bactrocera dorsalis (Hendel) sterile males. Function prediction of gut microbiota indicated that changes in microbiome taxonomy tend to drive microbiome functional shifts. A higher nutrient consumption of the flourishing minor gut microbiota may cause a decline in nutrients and energy metabolic activity of host and then result in the reduced ecological fitness of irradiated flies. Furthermore, we found that a gut bacterial strain Klebsiella oxytoca (BD177) can restore ecological fitness by improving food intake and increasing haemolymph sugar and amino acid levels of irradiated B. dorsalis flies. Our findings suggest that gut symbiont‐based probiotics can be used as agents for reversing radiation‐induced ecological fitness decrease.
Clodronate improves lameness in horses without changing bone turnover markers
Authors: Mitchell A. , Wright G. , Sampson S. N. , Martin M. , Cummings K. , Gaddy D. , Watts A. E.
Published: August 2018

Background

Clodronate is prescribed to performance horses with lameness. Despite its clinical popularity, little research has been done to understand the effects of clodronate in the horse.

Objectives

Our objective was to determine if a single treatment with clodronate at the clinically approved dose altered bone remodelling, bone cell recruitment or lameness in the horse.

Study design

Twelve university‐owned equestrian team competition horses with a history of forelimb lameness due to navicular syndrome were randomised to receive either 1.4 mg/kg clodronate (CLODn = 6) or an equivalent volume ofLRS(CONT; n = 6) in a blinded manner.

Methods

Blood was evaluated weekly for 8 weeks before and after drug administration (clodronate or placebo) for bone turnover markersCTX‐I and osteocalcin. Lameness evaluations were performed to assess for change in lameness 1 week before and 1, 2, 3 and 8 weeks after drug administration. Coach questionnaires were performed to assess for change in ridden performance 1, 2, 3 and 8 weeks after drug administration. Bone cell recruitment was evaluated in vitro 2 weeks before and after drug administration.

Results

There were no differences in in vitro bone cell recruitment from whole bone marrow or in bone turnover markersCTX‐I or osteocalcin. A small but significant decrease in forelimb lameness was detected inCLODtreated horses 1 week after treatment (P = 0.005). There were no significant differences in hindlimb lameness. Coaches identified an improvement in performance significantly more often inCLODvs.CONT(P = 0.01) at week 8.

Main limitations

TwoCONThorses received intra‐articular anti‐inflammatory medication after treatment, which may have altered lameness results.

Conclusions

A single dose of clodronate appears to reduce lameness without producing detectable effects on bone turnover markers. Due to the long half‐life of a bisphosphonate drug, the effect of multiple doses on bone remodelling and lameness should be investigated.

The Summary is available in Portuguese ‐ see Supporting Information
Job shop planning and scheduling for manufacturers with manual operations
Authors: Yang Longzhi , Li Jie , Chao Fei , Hackney Phil , Flanagan Mark
Published: August 2018

Job shop scheduling systems are widely employed to optimise the efficiency of machine utilisation in the manufacturing industry, by searching the most cost‐effective permutation of job operations based on the cost of each operation on each compatible machine and the relations between job operations. Such systems are paralysed when the cost of operations are not predictable led by the involvement of complex manual operations. This paper proposes a new genetic algorithm‐based job shop scheduling system by integrating a fuzzy learning and inference subsystem in an effort to address this limitation. In particular, the fuzzy subsystem adaptively estimates the completion time and thus cost of each manual task under different conditions based on a knowledge base that is initialised by domain experts and then constantly updated based on its built‐in learning ability and adaptability. The manufacturer of Point of Sale and Point of Purchase products has been utilised in this paper as an example case for both theoretical discussion and experimental study. The experimental results demonstrate the promising of the proposed system in improving the efficiency of manual manufacturing operations.
Mean stress and plasticity effect prediction on notch fatigue and crack growth threshold, combining the theory of critical distances and multiaxial fatigue criteria
Authors: Benedetti Matteo , Santus Ciro
Published: August 2018

In the present work, we propose a robust calibration of some bi‐parametric multiaxial fatigue criteria applied in conjunction with the theory of critical distances (TCD). This is based on least‐square fitting fatigue data generated using plain and sharp‐notched specimens tested at two different load ratios and allows for the estimation of the critical distance according to the point and line method formulation of TCD. It is shown that this combination permits to incorporate the mean stress effect into the fatigue strength calculation, which is not accounted for in the classical formulation of TCD based on the range of the maximum principal stress. It is also shown that for those materials exhibiting a low fatigue‐strength‐to‐yield‐stress ratio σfl,R = −1/σYS, such as 7075‐T6 (σfl,R = −1/σYS = 0.30), satisfactorily accurate predictions are obtained assuming a linear‐elastic stress distribution, even at the tip of sharp notches and cracks. Conversely, for any materials characterized by higher values of this ratio, as quenched and tempered 42CrMo4 (σfl,R = −1/σYS = 0.54), it is recommended to consider the stabilized elastic‐plastic stress/strain distribution, also for plain and blunt‐notched samples and even in the high cycle fatigue regime still with the application of the TCD.
Volatile fatty acids (VFAs) and methane from food waste and cow slurry: Comparison of biogas and VFA fermentation processes
Authors: Tampio Elina A. , Blasco Lucia , Vainio Markku M. , Kahala Minna M. , Rasi Saija E.
Published: August 2018

The potential of various biomasses for the production of green chemicals is currently one of the key topics in the field of the circular economy. Volatile fatty acids (VFAs) are intermediates in the methane formation pathway of anaerobic digestion and they can be produced in similar reactors as biogas to increase the productivity of a digestion plant, as VFAs have more varying end uses compared to biogas and methane. In this study, the aim was to assess the biogas and VFA production of food waste (FW) and cow slurry (CS) using the anaerobic biogas plant inoculum treating the corresponding substrates. The biogas and VFA production of both biomasses were studied in identical batch scale laboratory conditions while the process performance was assessed with chemical and microbial analyses. As a result, FW and CS were shown to have different chemical performances and microbial dynamics in both VFA and biogas processes. FW as a substrate showed higher yields in both processes (435 ml CH4/g VSfed and 434 mg VFA/g VSfed) due to its characteristics (pH, organic composition, microbial communities), and thus, the vast volume of CS makes it also a relevant substrate for VFA and biogas production. In this study, VFA profiles were highly dependent on the substrate and inoculum characteristics, while orders Clostridiales and Lactobacillales were connected with high VFA and butyric acid production with FW as a substrate. In conclusion, anaerobic digestion supports the implementation of the waste management hierarchy as it enables the production of renewable green chemicals from both urban and rural waste materials.
Trace Element Characterisation of MAD‐559 Zircon Reference Material for Ion Microprobe Analysis
Authors: Coble Matthew A. , Vazquez Jorge A. , Barth Andrew P. , Wooden Joseph , Burns Dale , Kylander‐Clark Andrew , Jackson Simon , Vennari Cara E.
Published: August 2018

We document the composition of a natural zircon gemstone sourced from Madagascar, MAD‐559 – a new reference material for calibrating trace element mass fractions in zircon measured by SIMS. The composition of MAD‐559 was quantified by calibration relative to the well‐documented zircon reference material 91500, for which we compiled existing published data (Mg, Al, Y, rare earth elements, Hf, U, Th) and performed new measurements to characterise the mass fraction of less commonly measured elements (Li, Be, B, F, Na, P, K, Ca, Sc, Ti, Fe, Nb). Measurement results of SL13, CZ3 and MAD‐1 zircons and NIST SRM glasses were performed as quality control materials to test measurement bias and repeatability. We show the intermediate precision for most trace element measurement results of MAD‐559 to be between ± 3% and ± 5% RSD based on 139 measurements by SIMS on twenty‐five individual polished zircon chips measured during a 24‐h period, as well as repeat measurements performed over five separate analytical sessions. Trace element mass fractions were also measured by LA‐ICP‐MS in two different laboratories, and major element compositions measured by electron microprobe, to compare with results measured by SIMS. Based on laser Raman and hyperspectral cathodoluminescence spectroscopy, we show MAD‐559 to have high crystal disorder due to radiation damage relative to crystalline zircon (e.g., SL13 and 91500 zircon). Although the high cumulative alpha dose of MAD‐559 zircon makes it a poor reference material for geochronology, the consistency of the trace element mass fraction results measured in multiple sessions and by various measurement methods shows that it is an ideal reference material for microanalytical trace element mass fraction quantification of zircon.
A GIS‐Based GOD Model and Hazard Index Analysis: The Quaternary Coastal Collo Aquifer (NE‐Algeria)
Authors: Boulabeiz Mahrez , Klebingat Stefan , Agaguenia Siham
Published: August 2018

The quaternary coastal Collo aquifer in northeast Algeria (NE Algeria) marks an important local water resource supporting domestic, industrial and agricultural activities. The aquifer shows signs of contamination due to the existence of various pollution sources, especially nitrogen compounds. Focusing the local identification of key vulnerable zones and related main hazard types for wise future water management, the present study highlights results from a coupled analysis of the well‐established Geographical Information System (GIS)‐based GOD (groundwater occurrence, overall aquifer class, depth to groundwater) hazard index analysis and the COST Action 620 plan. Most prevalent hazard types in the study area were identified as the urban/residential areas without public sewage systems, landfill and agricultural/pasturing areas. Regarding the vulnerability analysis particularly the northern aquifer region is endangered, dominated by high (22.4%) and moderate (27.4%) vulnerability classes. Central, western and southern aquifer regions are characterized by low (23.3%) and very low (26.9%) vulnerability classes. Overall, these GOD‐derived results are in good agreement with earlier results obtained by the more complex DRASTIC approach. Final risk assessment and validation related to 2014/2015 nitrate sampling campaigns indicate that “high risk” and “very high risk” classes only apply to a small part of the study area in the northern sector (8%), whereas the main part (>60%) broadly affecting the central, western and southern sector only bears a low to very low risk of water pollution. Apart from a future‐oriented groundwater abstraction strategy it is recommended to update the evaluation regularly to effectively consider dynamic changes of local anthropogenic activities and hazards.
Symptoms of Autonomic Dysfunction Among Those With Persistent Posttraumatic Headache Attributed to Mild Traumatic Brain Injury: A Comparison to Migraine and Healthy Controls
Authors: Howard Levi , Dumkrieger Gina , Chong Catherine D. , Ross Katherine , Berisha Visar , Schwedt Todd J.
Published: August 2018

Background

Most persistent posttraumatic headaches (PPTH) have a phenotype that meets diagnostic criteria for migraine or probable migraine. Although symptoms of autonomic dysfunction have been well described among those with migraine, the presence and relative severity of such symptoms among those with PPTH have yet to be reported.

Objective

The objective of this study was to assess and compare symptoms of autonomic dysfunction among those with PPTH attributed to mild traumatic brain injury (mTBI) vs migraine vs healthy controls using Composite Autonomic Symptom Score 31 (COMPASS‐31) questionnaire scores.

Methods

Individuals with PPTH (n = 56) (87.5% of whom had a migraine/probable migraine phenotype), migraine (n = 30), and healthy controls (n = 36) were prospectively assessed in this cross‐sectional cohort study using the COMPASS‐31 questionnaire. Total COMPASS‐31 scores and individual domain scores (bladder, gastrointestinal, orthostatic intolerance, pupillomotor, secretomotor, vasomotor) were compared between subject groups.

Results

COMPASS‐31 mean total weighted score was 37.22 ± 15.44 in the PPTH group, 27.15 ± 14.37 in the migraine group, and 11.67 ± 8.98 for healthy controls. COMPASS‐31 mean weighted total scores were significantly higher in those with PPTH vs migraine (P = .014), for PPTH vs healthy controls (P = .001), and for migraine vs healthy controls (P = .001). Those with PPTH had numerically higher scores for all COMPASS‐31 domains compared to those with migraine, and the domain scores were significantly higher for orthostatic intolerance (PPTH = 4.80 ± 2.47 vs migraine = 3.33 ± 2.31, P = .027) and bladder (PPTH = 1.14 ± 1.45 vs migraine = 0.47 ± 0.73, P = .020). Among individuals with PPTH, post hoc correlations indicated a positive association between number of total lifetime TBIs with total weighted COMPASS‐31 scores (rho = 0.32, P = .020), between years lived with headache and vasomotor domain subscores (rho = 0.27; P = .044), and between headache frequency with vasomotor domain subscores (rho = 0.27; P = .041).

Conclusions

Symptoms of autonomic dysfunction were greatest among those with PPTH compared to migraine and healthy controls. Among individuals with PPTH, number of lifetime TBIs was associated with greater symptoms of autonomic dysfunction, while greater headache burden was associated with higher vasomotor domain autonomic dysfunction subscores, potentially indicating that PPTH patients with higher disease burden have an increased risk for having autonomic dysfunction. Symptoms of autonomic dysfunction should be ascertained during the clinical management of patients with PPTH and might be a characteristic that helps differentiate PPTH from migraine.
Effect of loop diuretics on skeletal muscle depletion in patients with liver cirrhosis
Authors: Hanai Tatsunori , Shiraki Makoto , Miwa Takao , Watanabe Satoshi , Imai Kenji , Suetsugu Atsushi , Takai Koji , Moriwaki Hisataka , Shimizu Masahito
Published: August 2018

Aim

Sarcopenia, the loss of skeletal muscle mass, impairs prognosis of patients with liver cirrhosis. The aim of this study was to investigate the effect of loop diuretics, which are frequently used to treat hepatic edema/ascites, on skeletal muscle depletion and the prognosis in patients with liver cirrhosis.

Methods

This retrospective study evaluated 226 patients with liver cirrhosis. The skeletal muscle cross‐sectional area at the level of the third lumbar vertebra was measured using computed tomography. The relative change in skeletal muscle area per year (ΔSMA) was calculated, and the association between ΔSMA and therapeutic dosage of loop diuretics was examined.

Results

The therapeutic dosage of loop diuretics was inversely correlated with ΔSMA by simple (r = −0.27, P < 0.0001) and multiple regression analyses (t = −3.07, P = 0.002). During a median follow‐up period of 49 months, 82 patients died. Overall survival rates were lower in patients treated with loop diuretics at >20 mg than in those who received ≤20 mg (median, 66 vs. 97 months; P = 0.002). Multivariate analysis revealed that loop diuretics of >20 mg (hazard ratio [HR], 1.86; 95% confidence interval [CI], 1.03–3.24; P = 0.039) and ΔSMA of ≤−3.1% (HR, 3.87; 95% CI, 2.32–6.60; P < 0.0001) were independently associated with mortality.

Conclusions

A higher dose of loop diuretic use was associated with more rapid skeletal muscle depletion and poor survival in patients with liver cirrhosis, independent of the severity of liver disease.
Effect of CaO/MgO ratio on the optical and theoretical parameters of alumino‐borosilicate glasses
Authors: Kaur Mandeep , Kaur Gurbinder , Pandey Om Prakash , Kumar Vishal
Published: August 2018

Glass series (10+x)CaO–(10−x)MgO–10SrO–10B2O3–20Al2O3–40SiO2 (x = 0, 2.5, 5, 7.5) has been prepared by melt quenching technique. Influence of CaO/MgO (R) ratio on the properties like density/molar volume has been investigated and correlation has been established between them. The theoretical parameters like electronegativity of metal ion/oxide ion, ionic concentration, interionic distance, optical basicity, and polarizability have also been obtained. The optical properties such as band gap, Urbach energy, and band positions of pristine as well as heat‐treated glasses have been studied using UV‐visible and Fourier transform infrared spectroscopy (FTIR), respectively. Electron paramagnetic resonance (EPR) spectra are obtained to find the values of spin Hamiltonian parameters (g values) for all the glass samples. It could be observed that with the increase in CaO content or R ratio, heat‐treated glasses exhibit direct band gap within 5.92‐6.01 eV range. The Urbach energy lies within the 0.62‐0.86 eV range for all the heat‐treated glass samples.
Financial service providers: Does it matter if banks don't behave ethically?
Authors: Patterson Zoe , McEachern Morven G.
Published: August 2018

The ethical consumer literature predominantly concentrates on fast‐moving consuming goods and thus, neglects insights to consumer behaviour within ethical services. As the financial services sector continues to grow in the UK, this paper addresses this anomaly by providing further insight into consumers and their ethical banking practices. More specifically, it examines their motivations as well as the trade‐offs and barriers which prevent greater uptake. Using a combination of in‐depth interviews and projective techniques, the research draws on Freestone and McGoldrick's model to reveal a lack of awareness towards ethical financial service providers and sheds light on various perceptions regarding what constitutes an ethical financial service. Additionally, numerous underlying personal benefits of ethical financial services became apparent alongside consumer expectations of customer care. In conclusion, our findings help to create a revised model which identifies more precisely the stages of ethical awareness, motivation and behaviour of ethical consumers both in the context of ethical financial services but also ethical consumption practices in general.
Bank Work Experience Versus Political Connections: Which Matters for Bank Loan Financing?
Authors: Pan Xiaofei , Tian Gary Gang
Published: August 2018

This paper examines how bank lending decisions are affected either by executives’ connections with banks, through their former banking experience, or by their political connections with governments, using a sample of bank loans granted to Chinese listed non‐state‐owned enterprises (SOEs) from 2003 to 2010. We find that bank loans are more closely related to profitability for firms with bank connections, while firms’ political connections weaken this relationship. We further find that the influence of bank connections is more significant for firms from less supported industries or less developed regions. Furthermore, firms with bank connections are less likely to become financially distressed after the initiation of their bank loans and experience higher future stock returns, while firms with political connections experience the opposite outcome. Overall, our results indicate that in the context of a relationship‐based economy like China, firms’ connections with banks create value by alleviating information asymmetry and improving banks’ lending decisions, while political connections result in capital misallocation and subsequent deterioration in performance.
The use of prosthetic mesh for abdominal wall repairs: A semi‐systematic‐literature review
Authors: Wales Emily , Holloway Samantha
Published: August 2018

Following abdominal wall surgery, incisions are commonly sutured, stapled, or glued together by primary intention. Developments within the field of tissue engineering have led to the use of prosthetic meshes, with over 20 million meshes implanted each year worldwide. The function of the mesh is to hold together abdominal wall incisions and repair abdominal hernias. This has been demonstrated to be highly effective in some individuals; however, some patients have experienced postoperative complications, including dehiscence with further abdominal herniation (viscera protruding through the abdominal wall). Little is currently known about why these complications occur in a subset of patients who have had prosthetic mesh implants in abdominal wall repairs; therefore, this literature review examined existing studies identified via six electronic databases. A total of 463 studies were identified, of which 13 were included in this review. The results identified that the prosthetic mesh is highly successful in a large proportion of patients who have had a had a hernia repair in a range of locations; however, the prosthetic mesh has long‐term complications, with rejection being observed in a subset of patients. The reason why the prosthetic is being rejected is still largely unknown, and therefore, further investigation needs to be carried out.
Global population records and managed‐programme updates for the great apes: short report
Authors: Fisken F. A. , Carlsen F. , Elder M. , de Jongh T. , Pereboom J. J. M. , Pohl B. , Rietkerk F. , Ross S. R. , Taniguchi A.
Published: August 2018

Keeping records of individual wild animals managed by zoos and aquariums is an essential component of population management, not only on the institutional scale but also to ensure long‐term health and viability of species populations regionally and globally. There are long‐established studbooks for Bornean orangutan Pongo pygmaeus, Sumatran orangutan Pongo abelii, Bonobo Pan paniscus, Chimpanzee Pan troglodytes sspp and Western lowland gorilla Gorilla gorilla gorilla. National and regional zoo and aquarium associations manage these population records through a variety of conservation programmes, ensuring the data are available for those working to conserve great apes and their habitats. This report presents updates for the great ape managed conservation programmes, with specific data provided for the 2016 global zoo populations.
Optical and thermal properties of TiO2‐doped Y2O3 transparent ceramics synthesized by hot isostatic pressing
Authors: Li Xiaokai , Zhu Qiangqiang , Xu Yangyang , Mao Xiaojian , Feng Minghui , Jiang Benxue , Zhang Long
Published: August 2018

Highly transparent Y2O3 ceramics using TiO2 as an additive were synthesized by presintering and hot isostatic pressing (HIP). The effects of TiO2 contents and sintering conditions on the optical properties of the final transparent ceramics were investigated. A small amount (0.04‐0.16 wt%) may decrease the densification temperature by about 200°C. The Y2O3 ceramics doped with 0.16 wt% TiO2 revealed a transparency of 82% in the wavelength range 1‐6 μm. The thermal conductivity of the samples is about 11.8 W/m K at 25°C, which is close to that of the undoped Y2O3 ceramics.
Sprouty2 suppresses progression and correlates to favourable prognosis of intrahepatic cholangiocarcinoma via antagonizing FGFR2 signalling
Authors: Xu Yun‐Fei , Liu Hong‐Da , Liu Zeng‐Li , Pan Chang , Yang Xiao‐Qing , Ning Shang‐Lei , Zhang Zong‐Li , Guo Sen , Yu Jin‐Ming
Published: August 2018

Fibroblast growth factor receptor 2 (FGFR2) was demonstrated to correlate to the progression and prognosis of intrahepatic cholangiocarcinoma (ICC) by numerous evidences. However, as a well‐recognized suppressor of FGFR2 signalling, the clinical significance of Sprouty (SPRY) family of ICC has not been investigated. In our study, the expressions of SPRY1‐4 in 20 pairs of fresh tumour tissues were detected with qPCR, and in 108 cases of paraffin‐embedded tissues with immunohistochemistry. The prognostic value of SPRY family in ICC was estimated with univariate analysis and multivariate analysis. As a result, SPRY2 was identified as an independent prognostic biomarker predicting favourable prognosis of ICC. High SPRY2 expression was correlated with good differentiation of ICC. With silencing SPRY2 expression, we demonstrated that SPRY2 could suppress FGFR2‐induced ERK phosphorylation, migration, invasion and epithelial‐mesenchymal transition (EMT) under FGF1 stimulation. By overexpressing SPRY2‐wide type or SPRY2‐Y55F, the tyrosine‐55 of SPRY2 was demonstrated to be essential in suppressing ERK phosphorylation, tumour invasion and EMT of ICC cells. In conclusion, SPRY2 was correlated with favourable prognosis of ICC via suppressing FGFR2‐induced ERK phosphorylation, invasion and EMT. The phosphorylation of SPRY2‐Y55 was required in this tumour‐suppressing function of SPRY2.
H1/pAIM2 nanoparticles exert anti‐tumour effects that is associated with the inflammasome activation in renal carcinoma
Authors: Chai Dafei , Liu Nianli , Li Huizhong , Wang Gang , Song Jingyuan , Fang Lin , Lu Zheng , Yao Hong , Zheng Junnian
Published: August 2018

Renal cell carcinoma (RCC) is a high metastasis tumour with less effective treatment available currently. Absent in melanoma 2 (AIM2) as a tumour suppressor might be used as a potential therapeutic target for RCC treatment. Here, we found that AIM2 expression was significantly decreased in RCC patient specimens and renal carcinoma cell lines (786‐O and OSRC‐2). To establish a safe and effective AIM2 gene delivery system, we formed the nanoparticles consisting of a folate grafted PEI600‐CyD (H1) nanoparticle‐mediated AIM2 gene (H1/pAIM2) as an effective delivery agent. Delivery of H1/pAIM2 in renal carcinoma cells could remarkably increase the expression of AIM2, and subsequently decrease cell proliferation, migration, and invasion as well as enhance cell apoptosis. In order to evaluate the therapeutic efficacy of AIM2 in vivo, H1/pAIM2 nanoparticles were injected intratumorally into 786‐O‐xenograft mice. Administration of H1/pAIM2 nanoparticles could inhibit the tumour growth as evidenced by reduced tumour volume and weight. Furthermore, Blockade of inflammasome activation triggered by H1/pAIM2 nanoparticles using inflammasome inhibitor YVAD‐CMK abrogated the anti‐tumoral activities of H1/AIM2. These results indicated the therapeutic effect of H1/pAIM2 nanoparticles was mainly attributable to its capability to enhance the inflammasome activation. H1/AIM2 nanoparticles might act as an efficient therapeutic approach for RCC treatment.