bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Using an Audiovisual CPR Feedback Device on Chest Compression Rate and Depth
Authors: Wee Jeremy CP , Nandakumar Mooppil , Chan Yiong Huak , Yeo Rowena SL , Kaur Kaldip , Anantharaman V , Yap Susan , Ong Marcus EH
Published: June 2022

Introduction: The aim of the study is to investigate the effect of using Automated External Defibrillator (AED) audiovisual feedback on the quality of cardiopulmonary resuscitation (CPR) in a manikin training setting. Materials and Methods: Five cycles of 30 chest compressions were performed on a manikin without CPR prompts. After an interval of at least 5 minutes, the participants performed another 5 cycles with the use of real time audiovisual feedback via the ZOLL E-Series defibrillator. Performance data were obtained and analysed. Results: A total of 209 dialysis centre staff participated in the study. Using a feedback system resulted in a statistically significant improvement from 39.57% to 46.94% (P = 0.009) of the participants being within the target compression depth of 4 cm to 5 cm and a reduction in those below target from 16.45% to 11.05% (P= 0.004). The use of feedback also produced a significant improvement in achieving the target for rate of chest compression (90 to 110 compressions per minute) from 41.27% to 53.49%; (P <0.001). The mean depth of chest compressions was 4.85 cm (SD = 0.79) without audiovisual feedback and 4.91 (SD = 0.69) with feedback. For rate of chest compressions, it was 104.89 (SD = 13.74) vs 101.65 (SD = 10.21) respectively. The mean depth of chest compression was less in males than in females (4.61 cm vs 4.93 cm, P = 0.011), and this trend was reversed with the use of feedback. Conclusion: In conclusion, the use of feedback devices helps to improve the quality of CPR during training. However more studies involving cardiac arrest patients requiring CPR need to be done to determine if these devices improve survival.

Key words: Cardiopulmonary resuscitation, Chest compression, Quality
Young Breast Cancer in a Specialised Breast Unit in Singapore: Clinical, Radiological and Pathological Factors
Authors: Teo Sze Yiun , Chuwa Esther , Latha Suvarna , Lew Yi Ling , Tan Yah Yuen
Published: June 2022

Introduction: Whilst only 5.5% to 7% of breast cancer occurs in women less than 40 years of age in the West, the incidence has been reported in up to 18% in Asian population. This study seeks to evaluate our unit’s experience in breast cancer in young women. Materials and Methods: A retrospective review of our database identified women with newly diagnosed breast cancer from January 2006 to February 2011. Patient demographics, clinical presentation, imaging and pathological findings and treatment received were determined. Results: Out of a total of 1160 women with breast cancer, 135 (11.6%) were under 40 years of age and made up our study population. The most common presentation was a self-detected breast lump. Most patients did not have a positive family history. Mammography demonstrated abnormal findings in 78% of patients. Ultrasound was very sensitive in the evaluation of a breast lump and demonstrated abnormal findings in 95%. Out of 129 women, 40 (31%) underwent breast-conserving surgery of which 5 (12.5%) proceeded to mastectomy due to involved margins. Also, 89 out of 129 women (69%) underwent mastectomy of which 19 (21.3%) had immediate reconstruction. Of a total of 121 primary resections, 94% were invasive ductal carcinoma while 15.5% were pure ductal in-situ carcinomas. The majority (61.2%) showed high grade disease. Conclusion: Most young breast cancer patients present with a self-detected breast lump and do not have a positive family history. A strong clinical index of suspicion and appropriate breast imaging workup are useful for the early and accurate diagnosis of breast cancer in young women. Key words: Breast carcinoma, Breast imaging, Family history, Symptoms, Young age
A Comparison of the Short-term Morbidity and Mortality Between Late Preterm and Term Newborns
Authors: Tan Justin HT , Poon Woei Bing , Lian Wee Bin , Ho Selina KY
Published: June 2022

Introduction: Late preterm babies are defined as those born between 34 to 36 completed weeks. There has been a recent increased awareness that this group of babies has a higher incidence of morbidity as compared to term babies. The aim of this study was to evaluate the short-term morbidities occurring in this group of babies managed in the neonatal unit at Singapore General Hospital (SGH). Materials and Methods: A retrospective study was done of babies managed in the neonatal unit at SGH from January 2005 to December 2008. Maternal, perinatal and neonatal data were obtained from the departmental database. The outcomes of late preterm infants were compared with term infants. Results: A total of 6826 babies were admitted. Ten percent (681 out of 6826) of babies were late preterm babies, making up 63% (681 out of 1081) of all preterm babies. Late preterm babies had significantly greater need for resuscitation at birth. They also had statistically significant increased risks of developing hyaline membrane disease (2.5% vs 0.1%), transient tachypnoea of the newborn (TTN) (8.1% vs 1.7%), pneumonia (7.0% vs 2.8%), patent ductus arteriosus (PDA) (4.3% vs 1.1%), hypotension (0.7% vs 0%), apnoea (3.7% vs 0%), gastrointestinal (GI) bleeding (1.5% vs 0.3%), polycythaemia (2.2% vs 1.0%), anaemia (3.4% vs 1.2%), thrombocytopenia (3.2% vs 0.6%), hypoglycaemia (6.6% vs 1.7%), neonatal jaundice requiring phototherapy (41.1% vs 12.2%) and sepsis (1.7% vs 0.6%). Conclusion: Late preterm infants are indeed a vulnerable group of infants with significant morbidities that need to be addressed and treated. Despite their relatively large size and being almost term, the understanding that late preterm infants are not similar to term infants is important to both obstetricians and neonatologists.

Key words: Moderate preterm, Near term infants, Outcome, Prematurity, Preterm birth
Validation of the Paediatric Hearing Impairment Caregiver Experience (PHICE) Questionnaire
Authors: Lim Lynne HY , Xiang Ling , Wong Naomi LY , Yuen Kevin CP , Li Ruijie
Published: June 2022

Introduction: The paediatric hearing impairment caregiver experience (PHICE) questionnaire is a 68-item instrument that assesses the stress experienced by caregivers of children with hearing impairment (HI). While the questionnaire has been validated in the United States, it may need to be modified for use in the Singapore context due to the differing healthcare system, costing and culture related to caregiving for children with HI. This study aims to modify and validate the PHICE questionnaire to increase its relevance and ease of use in Singapore. Materials and Methods: The original PHICE questionnaire was filled out by 127 caregivers of HI children managed at the otolaryngology clinic of the National University Hospital (NUH). An expert panel was convened to assess the questionnaire for its suitability for use in Singapore. Exploratory factor analysis was conducted to evaluate the underlying factor structure of the original PHICE questionnaire. Items with high cross-loadings were removed and a new factor structure was adopted which was further analysed using confirmatory factor analysis (CFA). Cronbach’s alpha (α) was computed to determine the internal consistency of the new subscales. Results: Items that are less relevant in Singapore and those with high cross-loadings were removed. A 5-factor structure with only 42 items remaining and corresponding to the factors: “ Policy”, “Healthcare”, “Education”, “Support” and “Adaptation” was adopted. CFA suggests a good model fit for the modified questionnaire, improved from the 8-factor structure of the original PHICE. Cronbach’s α were high (>0.7) for each new subscale. Conclusion: The original PHICE questionnaire has been shortened and reorganised in terms of the subscales composition. The resulting instrument is structurally valid and internally consistent. It is a simple and useful tool for identifying factors related to caregiving that can negatively impact rehabilitation outcomes for children with HI in Singapore. Removal of some sign language items makes this modified version less useful for caregivers, places or countries where sign language is the main focus of rehabilitation for children with HI.

Key words: Modified, Outcome, Rehabilitation, Stress
Use of the National Early Warning Score (NEWS) to Identify Acutely Deteriorating Patients with Sepsis in Acute Medical Ward
Authors: Lim Wan Tin , Fang Andrew HS , Loo Chian Min , Wong Kok Seng , Balakrishnan Tharmmambal
Published: June 2022

Introduction: The National Early Warning Score (NEWS) is well established in acute medical units to identify acutely deteriorating patients and is shown to have good prognostic value. NEWS, however, has only been used in the Emergency Department as a triage tool. We aimed to evaluate the validity of NEWS in Acute Medical Ward (AMW) that treats predominantly acute infection-related conditions to the Internal Medicine service. Materials and Methods: We undertook a retrospective cohort study and analysed NEWS records of all patients admitted to AMW at Singapore General Hospital between 1 August 2015 and 30 July 2017. The outcome was defined as deterioration that required transfer to Intermediate Care Area (ICA), Intensive Care Unit (ICU) or death within 24 hours of a vital signs observation set. Results: A total of 298,743 vital signs observation sets were obtained from 11,300 patients. Area under receiver operating characteristic curve for any of the 3 outcomes (transfer to ICA, ICU or death) over a 24-hour period was 0.896 (95% confidence interval, 0.890-0.901). Event rate was noted to be high above 0.250 when the score was >9. In the medium-risk group (score of 5 or 6), event rate was <0.125. Conclusion: NEWS accurately triages patients according to the likelihood of adverse outcomes in infection-related acute medical settings.

Key words: Death, Infection, Intensive care, Intermediate care
Proposed Augmented Reality (Instagram Filter Try-On) as Promotion Strategy to Increase Brand Awareness for Start-Up Business (Case Study on Small and Medium Enterprise Fashion Brand Boboya Wear)
Authors:   Master of Business Administration, School of Business and Management, Bandung Institute of Technology, Prayogio Dimas Kamil
Published: June 2022

Boboya Wear is a local fashion brand that specializes in women’s fashion that offers daily wear that has unique embroidery accents on each product and has a variety of colors. The main issue of Boboya Wear is bad product sales and tend to be unstable, so that it becomes an issue for Boboya Wear. The purpose of this research is to find out solutions to solve company problems. One of the problems faced by Boboya Wear is that the product is not relevant to what consumers want or the trend regarding the product has out of trend. Resulting in fluctuating sales and a small variety of products so that consumer choices are low and this caused by bad production timeline and inconsistent promotion strategies. To analyze more deeply the researchers used primary data by distributing questionnaires to analyze consumers and used secondary data from Boboya Wear Instagram and Shopee Insight. Researchers used Ishikawa fishbone diagrams to find out more about the problems faced by Boboya Wear. After analyzing the internal and external situation of Boboya Wear using 4Ps marketing mix, SWOT, STP, five forces porter, competitor analysis, and customer analysis. The solution is to implement AR Instagram filter try-on as promotion strategy and develop new products and packaging, collaborate with influencers using AR try-on, create bundling promo, and educate the audience about AR try-on technology. The AR try-on technology used is Instagram filter because the installation cost is cheaper and easier. The results of the questionnaire from total 100 respondents agreed that the implementation of AR Try-on could help them in choosing the product they wanted and create shopping experience more pleasant and fun. The business implementation plan that will be carried out is by optimizing the implementation of AR try-on, making new products and packaging and implementing AR try-on.
Endocrine Disorders and Hormonal Therapy for Adolescent Acne
Authors:   Assumption University of Thailand, Bang Sao Thong, Samut Prakan, Thailand 10570, Assawaruangsin Chittinan
Published: June 2022

Acne vulgaris is a worldwide disease which is mostly found in teenagers. This has a crucial impact on their life’s quality, particularly when endocrine disorders have been implicated. Current consideration regarding antibiotic stewardship, failing with antibiotic utilization, and the improvement of antibiotic-resistant Propionibacterium acnes, there are many treatment alternatives for pimple therapy have been acknowledged. A following analysis investigates hormonal treatments for the therapy of acne vulgaris.
Knowing How It Works: Voices of Secondary School Heads on Local Government Special Education Fund for Technological Support in the New Normal
Authors:   Santa Rosa City, Laguna, Philippines 4026, Gomez Miguel P
Published: June 2022

Structured with qualitative-transcendental phenomenology, the study aimed at understanding the lived experiences of secondary school heads on the local government Special Education Fund for technological support in the new normal in the Division of Santa Rosa, Laguna, Philippines. The researcher utilized the framework of Moustakas (1994), which involved bracketing, horizonalization, theme clustering, textural description, structural description, and essence. From the verbatim transcriptions, 14 themes surfaced, which were intensively analyzed. The participants' lived experiences of receiving local government fund-derived technological support to match the demands of distance learning and implementation of basic education learning continuity were relative to intricate experiences, retorts on transitional education, knowledge of local government fund, perceived support and downsides, realization of fund accessibility and decision-making, meeting the demands of distance learning, and usefulness and impacts on school outcomes. Consequently, the participants' coping mechanisms in facing challenges and issues are manifested through prioritizing health and security, provision of sufficient and equitable technological support, congruency of actual needs, operative management schemes, strategic fund allocation, dynamism in training, workshops, and technical assistance, and collaboration towards positive support. The findings imply that in the new normal, the provision of local government for technological support in schools aided the successful implementation of distance learning via the virtual learning modality. The technological devices, such as laptops for teachers and tablets for students, helped a lot in complying with the required tasks while ensuring health and safety precautions.
Olanzapine Induced Pedal Edema: A Prudent and Rare Side Effect: A Case Report
Authors:   Psychiatry, All India Institute of Medical Sciences, Jodhpur, Jodhpur, India, Kumar Soni Puneet
Published: June 2022

Premarketing trials of olanzapine reported an occurrence of peripheral edema of 3%. Olanzapine belongs to atypical antipsychotics and is considered superior to its traditional congeners. Here we document a case of bilateral pedal edema which was developed secondary to olanzapine use, where all the systemic causes of pedal edema were ruled out. Pedal edema regressed on decreasing the dose of olanzapine and completely gets resolved after stopping the drug. So, we attribute the pedal edema to olanzapine drug therapy. As the definitive cause of pedal edema along with its consequences are not known, so stringent monitoring of this drug’s adverse effects is needed.
Investigating the Multidimensional Comorbidity of ObsessiveCompulsive Disorder, Body Dysmorphic Disorders, and Eating Disorders: Theoretical and Practical Approaches to Treatment
Authors:   The Westwood Institute for Anxiety Disorders, Los Angeles, CA, Gorbis Eda
Published: June 2022

Research on obsessive-compulsive disorder (OCD), body dysmorphic disorder (BDD), and eating disorders (EDs), including anorexia and bulimia, has shown appreciable two-way comorbidity between these conditions, especially OCD and BDD. There are few, if any, however, assessments of the multidimensional comorbidity of OCD, BDD, and EDs. Here, we review the literature on prevalence and comorbidity of these disorders and estimate their three-way comorbidity. We calculate that multidimensional comorbidity of OCD, BDD, and EDs is present in about 1.5% of cases of primary OCD, 3.7% of cases of primary BDD and 9.8% of cases of primary EDs. We further provide recommendations for treatment of cases in which all three disorders appear together, beginning with the advice to treat that disorder first which poses the highest danger to the patient upon check in. for LVM.
Clinical Significance of Color Doppler Ultrasound Applied in Patients with Peripherally Inserted Central Venous Catheters before Extubation: A Retrospective Analysis of Real-World Data
Authors:   Central South University Xiangya School of Nursing, Master’s Student, China, AN Ran , CHEN Wen-feng ,   Teaching and Research Section of Clinical Nursing, Xiangya Hospital Central South University, Teaching Nurse, China, ZENG Qiao-miao ,   Nuclear Medicine Department, Xiangya Hospital of Central South University, Associate Professor, China
Published: June 2022

Aims and Objectives: By comparing peripherally inserted central venous catheter (PICC)-related complications in real-life patients, we aimed to analyze the significance of color Doppler ultrasound (CDU) applied routinely or once with symptoms of thrombosis before extubation. Methods: For this retrospective study, patient data from January to December 2020 were collected from an intelligent safe platform for infusion, which was embedded in the hospital information system (HIS). After screening by the inclusion and exclusion criteria, venous therapy liaisons were interviewed regarding the PICC procedures and complications of the enrolled patients. Then, the patient medical records were checked to verify the CDU usage and collect the CDU results. Difficulties in extubation and serious complications, including catheter fracture or pulmonary embolism during or after extubation, were also collected. This paper adheres to the RECORD checklist of EQUATOR guidelines. Results: Of the 1455 patients, 489 underwent CDU examination before extubation. Among these, thrombosis was detected in 37 (7.6%) patients and only 1 (0.2%) patient without thrombosis experienced difficulties in extubation. No serious complications were observed in the CDU group. Meanwhile, among the 966 patients in the non-CDU group, three (0.3%) faced difficulties and one patient developed symptoms of pulmonary embolism. Furthermore, among patients with thrombosis in the CDU group, the duration of catheter retention was significantly shorter than that in patients without thrombosis (76.65±42.55 vs. 121.04±45.99 days, P <0.001). Conclusions: After evaluation of their clinical symptoms, patients without symptoms could be directly removed according to conventional procedures, while patients with symptoms should undergo CDU examination before extubation. Relevance to Clinical Practice: When removing the catheter for PICC carriers, it is assessed that the patients have no discomfort symptoms and can be directly extubated without B-ultrasound examination.
ИННОВАЦИОННАЯ АКТИВНОСТЬ РЕГИОНОВ КАЗАХСТАНА
Authors: Karimbayeva Gulzhan , Zhumabayeva Myrzabike , Ibragimova Natalia
Published: June 2022

По различным оценкам, 70-100% прироста производства в современном мире обеспечивается за счет инновационных технологий. Инновации решают вопросы социального и экономического развития, меняют качество жизни, структуру потребления, поведение людей, состояние окружающей среды, культуру производства и многое другое. Изменения в социальной сфере в Казахстане происходят так же динамично, как и во всем мире, однако, пока инновационное развитие в сфере производства продукции пока отстает от темпов преобразований в развитых странах. Немаловажную роль в развитии инноваций играют регионы. Учитывая значимость развития инноваций на региональном уровне, в статье на основе изучения литературных источников исследованы вопросы формирования региональной инновационной системы, инновационного потенциала региона, проанализированы показатели инновационной активности регионов Казахстана за 2020 г. Анализ проведен с использованием статистических данных, проведено ранжирование по 9 показателям, а затем ранжирование регионов с точки зрения инновационной активности. Исследование проводилось путем использования методов формальной логики, сравнения количественных показателей инновационной активности регионов по официальным данным Бюро национальной статистики Агентства по стратегическому планированию и реформам Республики Казахстан, также использован метод рейтинговой оценки. Исследование проводилось в несколько этапов.
ХАЛЫҚАРАЛЫҚ ТЕРРОРИЗМ МЕН ЭКСТРЕМИЗМГЕ ҚАРСЫ ІС-ҚИМЫЛДЫҢ ӨЗЕКТІ МӘСЕЛЕЛЕРІ: ХАЛЫҚАРАЛЫҚ ТӘЖІРИБЕ ЖӘНЕ ҚАЗАҚСТАН
Authors: Shaikhadenov Renat
Published: June 2022

Мақалада ХХІ ғасырдың қорқынышты құбылысына айналған терроризм мен экстремизмге қарсы күрестің іс-қимыл мәселелері және азаматтар мен мемлекеттің қауіпсіздігін қамтамасыз етудегі шет елдердің оң тәжірибесі қарастырылады.
Автор терроризм мен экстремизмді мемлекеттердің ұлттық және халықаралық қауіпсіздігіне негізгі қауіп ретінде анықтайды. Бұл қатерлер неғұрлым ауқымды және жаһандық сипатқа ие болғандықтан, халықаралық қоғамдастық осы құбылысқа қарсы күрестің жалпы саясатын әзірлеуі тиіс, өйткені тек белсенді мемлекетаралық ынтымақтастықтың арқасында ғана терроризмге қарсы шаралардың тиімділігіне қол жеткізуге болады.
Бүгінгі таңда Біріккен Ұлттар Ұйымы терроризм мен экстремизмге қарсы іс-қимыл саласындағы құқықтық тұжырымдамаларды біріздендіруге, террористік және экстремистік сипаттағы қылмыстардың алдын алу мен жолын кесудің бірыңғай тетіктерін жасауға бағытталған бірқатар конвенциялар мен хаттамаларды қабылдады. Мақалада аталған халықаралық конвенциялардың негізгі ережелеріне терең талдау жасалады және олардың бүкіл әлемдегі қауіпсіздікті қамтамасыз ету үшін маңызы бағаланады.
Қазақстан Республикасының терроризм мен экстремизмге қарсы іс-қимылдың тәжірибесі мол болмағандықтан, көптеген жылдар бойы терроризм мен экстремизммен күресіп келе жатқан шет елдердің заңнамасы мен құқық қорғау органдарының практикасын зерделеу мәселелері ерекше маңызды болып табылады. Автор әртүрлі мемлекеттердің терроризмге және экстремизмге қарсы іс-қимыл жөніндегі тиісті құзыретті органдарының бірлескен қызметінің қазіргі тәжірибесіне талдау жасады, осы саладағы халықаралық ынтымақтастықты одан әрі дамыту бойынша негізделген ұсыныстар берді. Шетелдік тәжірибені зерделеп, оны жүйелеп, Қазақстанның жағдайына бейімдеп, терроризм мен экстремизмге қарсы күрес жөніндегі шараларды оңтайландыруға, сол арқылы осындай күрестің құралдары мен әдістерін таңдауда ықтимал қателіктерге жол бермеуге болады.
Prevalence of Calcium Channel Blocker Induced Ankle Edema and its Treatment in a Cohort of Newly Diagnosed Hypertensive Patients
Authors: Onah Paul Otor , Idoko Catherine Chioma , Abdulateef Siyaka
Published: June 2022

Background: Calcium channel blockers are widely prescribed either as monotherapies or in combination therapies in the management of hypertension and other cardiovascular disorders. One of the major challenges with this class of drugs is their association with difficult to treat peripheral edema. There is limited literature evidence on the incidence and severity of CCB induced edema and the efficacy of management practices in developing countries. This study therefore aims to assess incidence and the common treatments. Methods: A total of 193 eligible subjects were enrolled into an eight week study and allocated into three treatment groups for each drug [Amlodipine 10mg or Nifedipine 20mg]. One group received no intervention, while the other two groups received either Bendrofluthiazide 5mg [BDF] or Lisinopril 5mg depending on blood pressure or other patient factors. Edema was monitored every two weeks throughout the study using standard tools. The data were analyzed using students t test, one way ANOVA and descriptive statistics as appropriate. P values ≤ 0.05 was considered statistically significant. Results/Discussion: The overall incidence of edema was about 29% at the end of the study period. Lisinopril addition to therapy resulted in significant reduction in incidence and severity of edema as opposed to other interventions. This suggests that ACEIs have a positive role in minimizing incidence of peripheral edema. Conclusion: Peripheral edema remains a complication factor in CCB therapy and ACEIs may be considered in management of edema induced by this class of drugs.
Covid-19 Salgın Döneminde Okul Psikolojik Danışmanlarında Travma Sonrası Büyüme: Bilinçli Farkındalık ve Acının Dönüştürücü Gücünün Rolü
Authors: UĞUR Ahmet , SARI Tuğba
Published: June 2022

Bu araştırmanın amacı COVID-19 salgın döneminde okul psikolojik danışmanlarında bilinçli farkındalık ile acının dönüştürücü gücünün travma sonrası büyümenin anlamlı yordayıcıları olup olmadığını ortaya koymaktır. Ayrıca okul psikolojik danışmanlarının travma sonrası büyüme puanlarının çocukluk döneminde travma yaşama durumu ve hizmet yılına göre farklılaşıp farklılaşmadığı incelenmiştir. Araştırmanın çalışma grubunu araştırmacıların hazırladığı online ölçek formlarını dolduran Türkiye’nin yedi coğrafi bölgesinde görev yapan 415 okul psikolojik danışmanı oluşturmaktadır. Araştırmanın verileri Acının Dönüştürücü Gücü, Travma Sonrası Büyüme ve Bilinçli Farkındalık Ölçekleri ile araştırmacılar tarafından hazırlanan katılımcı bilgi formu aracılığıyla toplanmıştır. Araştırma verileri COVID-19 salgınının en yoğun hissedildiği dönemde çevrimiçi platformlardan elde edilmiştir. Araştırma sonuçları çoklu regresyon analizi, pearson korelasyon analizi, kruskal wallis testi ve bağımsız örneklemler için kullanılan t testi ile elde edilmiştir. Araştırmanın bulguları incelendiğinde okul psikolojik danışmanlarının bilinçli farkındalık puanlarının travma sonrası büyümeyi anlamlı düzeyde yordamadığı ancak acının dönüştürücü gücü puanlarının travma sonrası büyümenin üçte ikisini yordadığı sonucuna ulaşılmıştır. İlave olarak okul psikolojik danışmanlarının travma sonrası büyümelerinin çocukluk travmasına sahip olma durumuna ve hizmet yılına göre anlamlı düzeyde farklılaştığı tespit edilmiştir.
Emerging of Three-Dimensional Models To Study Human Diseases
Authors: Al-Zeer Munir A.
Published: June 2022

For several decades, biomedical research has traditionally relied on the use of two-dimensional (2D) cell culture and animal models to study human biology and diseases. However, it can be difficult to address questions that are relevant to human biology and diseases in animal models or 2D cell culture, such as genetics, development, immune response, and cell host tropism. Furthermore, scarcity of advanced in vitro and in vivo models has hindered progress in understanding disease causes and, as a result, the creation of innovative therapeutic methods for patients. To improve our understanding and the current situation, more physiologically and realistic research models for mechanism-based target identification, drug development and screening, developmental biology, cancer and infectious diseases are needed.
Impact of Cutting Process Parameters on the Mechanical Quality of Processed Glass Edges
Authors: Bukieda Paulina , Weller Bernhard
Published: June 2022

The inspection of glass edges is gaining in importance in research, as the strength of a glass edge has been found to be highly dependent on its processing. Glass edges are produced by cutting. Depending on their type, they may be additionally seamed, ground or polished in the grinding process. Cutting and grinding processes create mechanical interference in the brittle material, leaving flaws and cracks in the edge surfaces. The current state of the art presents cutting process parameters which correlate with minor flaws and a high glass edge strength. Research at the Technische Universität Dresden aims to understand the impact of grinding processes and to develop parameters for processing glass edges with a defined and reproducible optical and mechanical quality. To isolate observations of the grinding process from the cutting process, this paper examines the impact of cutting process parameters on further processed glass edges. Several different cutting parameter-sets formed the basis of various test series that were performed on specimens whose glass edges were processed by the same manufacturer. This paper presents an optical and mechanical examination of the specimens. The results show that higher optical and mechanical qualities of the cut edge and arrised edge can be obtained by adjusting the cutting process parameters. It had no major impacts on smooth ground and polished edges.
Curtain of Glass – Textured by Stone
Authors: Engelmann Michael , Reuschle Klaus , Muscatello Salvatore , Sperandio Thomas
Published: June 2022

The new World Trade Center site was rebuilt after 9/11 comprising seven mayor skyscrapers around the memorial site and the 9/11 museum. Between WTC 2 and WTC 3, Santiago Calatrava’s Oculus Station spans its wings in the NY air while finally, the complex is completed by the “The Ronald O. Perelman Performing Arts Center”. This building sets a one-in-a-kind visual appearance to the area. Its four-sided, 42 m tall, even facade is made from 4736 equal-sized insulated glass panes. More specifically, the architectural vision is to create a marble stone front covered with glass which results in a stone-glass laminate as a part of an insulated glass unit. The marble shows a distinguished white face with crisp black veining. Each of the four elevations of the building impresses with a perfect symmetry and veins touching at the vertical center line. So, the design team at Josef Gartner was challenged to set-up a logistics chain from quarry in Portugal where the stone panels were cut and catalogued to glass production of laminated glass in France and IGUs in Germany and assembly of curtain wall mega-panels at Gartner in Germany up to the site in Lower Manhattan. Our in-house logistics concept, customized for this project, guarantees that each individual piece of stone finds its correct and unique spot defined by the architect on the 7,000 m2 surface – a large-scale game of “Matching Pairs”.                The steel base building provides a cantilevering roof that holds 128 hot-rolled steel mullions. Each 36 m in length with one intermediate lateral support only. This allows the visitor to experience a clear and unobstructed view along the transom-free facade elements that carry the translucent stone-wall. During the day, it appears white from the outside and shines with an amber-glow during the night when the interior space is illuminated.  We show the use of a novel stone-glass product that is exposed to a variety of requirements. The logistics chain is described from quarry to site making sure that the architectural and economical demand is met along the whole process. Finally, the team connects all branches in facade design using stone, aluminum, glass and architectural exposed structural steel assembled in one landmark project.
The Conjugate Beam Effective Thickness Method
Authors: Galuppi Laura , Nizich Adam , La Greca Andrea
Published: June 2022

The structural performance of laminated glass is strongly dependent on the shear coupling offered by the interlayer between the bounding layered and monolithic limits of the glass plies. The most common simplified design approach consists of defining the effective thickness, i.e., the thickness of a monolithic section with equivalent flexural section properties. The Enhanced Effective Thickness (EET) method has been verified to estimate deflection in laminated glass for a range of load and boundary conditions for two-, three-, and multi-ply beams; however, for some static schemes, the EET method is less accurate for predicting stress. The recently proposed Conjugate Beam Effective Thickness (CBET) method, initially developed for cantilevered laminated glass balustrade applications, accounts for the relative displacement of glass plies across the interlayer for a range of loads and statically determinate boundary conditions. In this paper, the CBET method is extended to the evaluation of two-ply simply supported beams under concentrated, uniformly, and tapered distributed out-of-plane loads. Predicted deflection- and stress-effective thickness obtained from effective thickness methods is compared with finite element model results in illustrative examples, demonstrating improved accuracy. Closed-form formulas are summarized in tables to facilitate the practical application of the CBET method in the design practice.
AİZANOİ ANTİK KENTİ’NDEKİ GLADYATÖR BETİMLERİ
Authors: ÖZCAN Sinan
Published: June 2022

Aizanoi Antik Kenti, Örencik Ovası platosunda, antik çağda Phrygia Epiktetos Bölgesi’nde yer alan bir Roma kentidir. Bu kentin en parlak dönemi Roma İmparatorluk Çağı’dır. Hadrianus ve Antoninler Dönemi’nde kent, yoğun biçimde imar faaliyetleri geçirdiği için bu dönemde kozmopolit bir yapıdadır. Kentin antik ve kırsal dokuyu aynı anda içinde barındırması, özel bir kültürel miras kimliği oluşturduğu için 2012 yılında “Unesco Dünya Kültürel Mirası Geçici Listesi’ne” kabul edilmiştir. Bu çalışmada, Aizanoi Antik Kentinde 1970-2020 yılları arasındaki çalışmalarda tespit edilen gladyatör betimlemeleri incelenecektir. Bu betimler kentteki çeşitli dönemlerdeki kazılarda tespit edilen bomoslar ve kandiller üzerinde görülmektedir. Özellikle bomoslardaki betimler Aizanoi’daki gladyatörlerin varlığını işaret etmekle beraber burada hangi türde oyunlar oynandığına dair bilgiler sunmaktadır. İncelenen kalıp yapımı kandillerin üzerindeki bezemeler Anadolu’daki diğer örnekler gibi discusta yer almaktadır. İncelenen bu eserlerin MS. 1. ile 3.yy. aralığında olduğu ve Aizanoi’un en parlak dönemini geçirdiği Roma İmparatorluk Çağı’na tarihlendirildiği saptanmıştır.
A Review on Spot Speed Survey of Maharashtra State Highway (SH-264) and National Highway (NH-44)
Authors: Mrs. P. H. Salodkar  , Mr. R. N. Bhosle  , Mr. Sharad Shambharkar  , Mr. Gourav V. Melekar  , Mr. Sudhanshu Shende  , Mr. Pratik Meshram
Published: June 2022

The spot speed study concentrates on measuring the speed characteristics at predetermined areas under the natural conditions. The spot speed studies are coordinated to assess the movement of rates of vehicles in a surge of activity at a particular region on a roadway. Designing and construction of a road involves estimation of traffic volume and setting up ideal speed for the vehicles to travel in a comfortable way. Now days, due to rapid increase in volume of traffic the designed speed on high ways could not be maintained resulting a delay in reaching target point. Our project also involves survey of spot speed of vehicles near a school zone. This helps us to recommend changes to the existing system. These recommendations may involve establishments of precautionary sighs like school zone, speed limit etc. This study includes the traffic volume and check the time to reach the target in off-peak timing on a highway Chandrapur-Ballarshah (SH264), Nagpur-Deolapar (NH44). The conclusion of the project is the solution to problems faced in chandrapur-ballarshah and Nagpur-deolapar Road journey by checking personally and taking feedback off public using the highway.
Caregiver Coaching in Early Intervention: A Scoping Review
Authors: Seruya Francine M. , Feit Emily , Tirado Alexys , Ottomanelli Diana , Celio Melissa
Published: June 2022

Importance: Best practice guidelines and legal mandates have deemed parent engagement an essential component of early intervention (EI). Parent coaching is an intervention and a model of service delivery used in occupational therapy practice that is designed to integrate parents into the therapy session.

Objective: To examine the current definitions of coaching and the ways in which U.S. occupational therapy practitioners are using coaching models in EI.

Study Selection and Data Collection: We systematically searched 11 databases—CINAHL Complete, CINAHL with full text, Education Research Complete, ERIC, PsycARTICLES, PsycINFO, Teacher Reference Center, Academic Search Premier, Academic Search Complete, Socindex with full text, and Social Work Abstracts—for articles published from 2000 through 2020. A total of 178 articles were retrieved, and 60 underwent full-text review. The final review included 16 studies of varying designs in which occupational therapy was one of the interventions and in which various definitions of coaching and models were used.

Findings: The concepts inherent in coaching models were consistent across studies. There was little emphasis on the efficacy of coaching models as related to goal attainment.

Conclusions and Relevance: Coaching is a viable intervention in EI. Studies are needed to assess the efficacy of the parent coaching model in achieving child and family outcomes and the training needed to provide the intervention appropriately.

What This Article Adds: This scoping review explores existing research on coaching interventions and models used by occupational therapists in EI. Findings indicate that this is an area of opportunity because the model of parent coaching strongly aligns with the professional scope of occupational therapy practice.
Microstructure of practice activities for team and individual sports
Authors: Tan Angelina Li San , Low Jeffrey Fook Lee
Published: June 2022

Purpose

Research on the microstructure of practice activities has reported equivocal findings. Limited sports have been included in systematic observations. Playing form activities have not been examined for individual sports. This study scrutinized the amount of time devoted to different activities during practice and refined the usability of playing form and training form for various sports.

Methods

Systematic observations were conducted in an elite sports school. Youth athletes aged 16–20 years and coaches from 6 different sports (hurdling, archery, field hockey, netball, squash, volleyball) were involved. Practice activities were categorized as playing form, training form, and transition, and compared between sports.

Results

The proportion of different activities conducted during practice varied for each sport and coach. Hurdlers employed the longest time on transition (43%), squash players utilized the majority of time on playing form (40%), whilst the archers and all 3 team sports athletes consumed most time on training form (51–83%). Representatives of 3 sports did not engage in any playing form activities.

Conclusions

This study showed that elite coaches are still applying traditional approaches in structuring practice activities. Coaches should employ playing form during practice sessions, but the definition needs to be adapted to encompass multiple sports.
KẾT QUẢ PHẪU THUẬT TẠO HÌNH SỤN CHÊM HÌNH ĐĨA QUA NỘI SOI KHỚP GỐI TẠI BỆNH VIỆN VIỆT ĐỨC
Authors: Đình Toàn Dương , Văn Nam Nguyễn , Trung Dũng Trần
Published: June 2022

Sụn chêm hình đĩa là một bất thường bẩm sinh hiếm gặp, tỉ lệ mắc từ 1 - 5%, trong đó hay gặp ở sụn chêm ngoài (0,4 - 17%), ở sụn chêm trong hiếm gặp hơn (0,06 - 0,3%). Mục tiêu: Đánh giá kết quả của phẫu thuật tạo hình sụn chêm hình đĩa qua phẫu thuật nội soi khớp gối tại bệnh viện Việt Đức. Phương pháp: mô tả cắt ngang hồi cứu trên 30 bệnh nhân, tuổi từ 9 đến 56 tuổi, được phẫu thuật nội soi khớp gối tạo hình sụn chêm hình đĩa. Đánh giá kết quả theo thang điểm Lysholm. Thời gian theo dõi trung bình 22,2 tháng. Kết quả: 98% bệnh nhân đạt kết quả tốt và rất tốt, 2% bệnh nhân đạt kết quả trung bình, không có bệnh nhân đạt kết quả kém. Không ghi nhận trường hợp nào gặp biên chứng hay di chứng sau mổ. Kết luận: Phẫu thuật tạo hình sụn chêm qua nội soi khớp gối hiện nay là phương pháp điều trị hiệu quả và an toàn cho bệnh lý sụn chêm hình đĩa.
LIÊN QUAN, TƯƠNG QUAN GIỮA NHỊP SINH HỌC HUYẾT ÁP VỚI MICROALBUMIN NIỆU Ở BỆNH NHÂN ĐÁI THÁO ĐƯỜNG TÝP II CÓ TĂNG HUYẾT ÁP
Authors: Trường Sinh Cao
Published: June 2022

Mục đích: Xác định mối liên quan, tương quan giữa các thông số huyết áp lưu động 24 giờ với microalbumin niệu ở bệnh nhân đái tháo đường týp II có tăng huyết áp. Đối tượng và phương pháp: 31 bệnh nhân đái tháo đường týp II có tăng huyết áp, 19 nam, 12 nữ, tuổi trung bình 63,71 ±6,9 năm, đồng ý tham gia nghiên cứu. Tất cả bệnh nhân được đo huyết áp lâm sàng bằng huyết áp kế thủy ngân, sau đó được đo huyết áp lưu động 24 giờ (Ambulatory Blood Pressure Monitoring-ABPM) bằng máy Suntech Oscar 2, USA với khoảng cách đo 30 phút/lần vào ban ngày từ 6 AM đến 10 PM và 60 phút /lần vào ban đêm từ 10PM đến 6 AM hôm sau. Tất cả bệnh nhân được làm xét nghiệm microalbumin niệu cùng ngày với ABPM. Kết quả: Nồng độ trung bình albumin niệu ở nhóm không trũng huyết áp ban đêm cao hơn có ý nghĩa nhóm có trũng huyết áp ban đêm, nhóm quá tải HATT 24h ≥ 50% cao hơn có ý nghĩa nhóm qúa tải HATT 24h < 50%. Có mối tương quan nghịch có ý nghĩa giữa nồng độ albumin niệu và phần trăm giảm huyết áp tâm thu ban đêm với p <0,05, r = -0,367; Có mối tương quan nghịch có ý nghĩa giữa nồng độ albumin niệu và phần trăm giảm huyết áp tâm trương ban đêm với p  < 0,05, r = -0,399. Kết luận: Có mối liên quan và tương quan giữa tình trạng không trũng huyết áp ban đêm và quá tải huyết áp với nồng độ microalbumin niệu ở bệnh nhân đái tháo đường týp II có tăng huyết áp.
Direct U-series dating of the Apidima C human remains
Authors:   DFG Center of Advanced Studies ", Harvati Katerina ,   Words, Bones, Genes, Tools,",   University of Tübingen, Grün Rainer , Duval Mathieu , Zhao Jian-xin , Karakostis Alexandros , Tourloukis Vangelis , Gorgoulis Vassilis , Kouloukoussa Mirsini ,   Senckenberg Centre for Human Evolution and Palaeoenvironments
Published: June 2022

The site of Apidima, in southern Greece, is one of the most important Paleolithic sites in Greece and southeast Europe. One of the caves belonging to this cave complex, Cave A, has yielded human fossil crania Apidima 1 and 2, showing the presence of an early Homo sapiens population followed by a Neanderthal one in the Middle Pleistocene. Less known are the human remains reportedly recovered from Cave C at Apidima. These include a number of isolated elements, but also a partial skeleton interpreted as a female burial, Apidima 3, proposed by Pitsios (e.g., Pitsios 1999) to be associated with Aurignacian lithics and to date to ca. 30 ka. In light of the rarity of the Upper Paleolithic in Greece, and the general scarcity of human remains associated with the Aurignacian, the remains from Apidima Cave C are potentially very significant in elucidating the arrival of the early Upper Paleolithic populations in Europe. Here we undertake direct Uranium-series dating of three human samples from Cave C, including the burial, to help clarify their chronology. Results suggest a minimum age of terminal Pleistocene for all three samples.
Genetic demography: What does it mean and how to interpret it, with a case study on the Neolithic transition
Authors:   Department of Zoology, University of Cambridge, Leonardi Michela , Barbujani Guido ,   Dipartimento di Scienze della vita e biotecnologie, Università di Ferrara, Manica Andrea
Published: June 2022

The present work describes the basic principles underlying demographic reconstructions from genetic data, and reviews the studies using such methods with respect to the Neolithic Demographic Transition. It is intended as a tool for scholars outside the field of population genetics (e.g., archaeologists, anthropologists, etc.) to better understand the significance and intrinsic limitations of genetic demography, and to help integrate its results within the broader context of the reconstruction of the human past.
Policy priorities for mobilizing investment in Swedish green industrial transitions
Authors:   Stockholm Environment Institute, Maltais Aaron , Karltorp Kersti , Tekie Haben
Published: June 2022

The aim of this report is to better understand the key challenges for investments in technological and production changes that bring deep emissions cuts in heavy industry in Sweden. In this report we refer to this as investments in deep green industrial transitions. We investigate this matter from the perspective of both industry actors and actors from the financial sector. We investigate the following research questions: •Is the size of the capital investments needed for green industrial production a significant challenge for bringing about these transitions in Sweden? •What are the most important challenges for actors’ willingness to invest in deep green industrial transitions and investors’ willingness to provide financing for those investments? •What policies do industrial and financial actors think can best support the willingness to invest in and provide financing for deep green industrial transitions in Sweden?
Application of a frequency-regulatory electric drive to reduce the operating costs of auxiliary needs of the GRES
Authors:   Far East state agrarian University, Kasyan Pavel , Shevchenko Maxim , Voyakin Sergey , Dubkova Elena
Published: June 2022

Economical operation of modern powerful boilers and condenser turbines of hydrorecirculation stations (GRES) is possible only when auxiliary installations (mills, crushers, cranes, conveyors, pumps, fans, etc.) are required for the preparation and transport of solid fuel, air supply to the chambers burning fuel and removing combustion products and ash from them, supplying water to boiler units, maintaining a vacuum in turbine condensers, water supply to the station, and much more. Recently, the specific costs of heat power plants used are 25-30% higher than those of power plants that use modern technologies. One of the priority areas for the development of modern energy in Russia is the technical re-equipment and reconstruction of obsolete operating hydrorecirculation stations with the extension of their service life and the replacement of the main and auxiliary equipment with new ones with improved technical and economic characteristics. The priority in this case is to increase the efficiency of fuel use, energy and resource saving. The article discusses the main causes of uneconomical modes of operation of electric drives during operation in the auxiliary system of JV Raichikhinskaya GRES. To improve the performance and service life of the multistage centrifugal feed water pump PE 270-150-3, the article proposes the use of a frequency-controlled electric drive. Keywords: AUXILIARY NEEDS, FEED WATER PUMP, ELECTRIC MOTOR, FREQUENCY-CONTROLLED ELECTRIC DRIVE
PROSPER MÉRİMÉE’NİN KALEMİNDE MİTLEŞEN BİR KADIN KARAKTER: CARMEN
Authors: KOL Mustafa
Published: June 2022

XIX. yüzyıl Fransız romantik yazarlarından Prosper Mérimée (1803-1870), arkeolog olduğu için çok seyahat eden bir yazardır ve bu nedenle de birçok ülkeyi görme fırsatı bulur. Bunlardan biri de İspanya’dır, o dönemde seyahat etmek pahalı olduğu için Fransız toplumunun yabancı ülkelere ve yabancıya olan ilgisi büyüktür. Bu çalışmamızda edebî bir modern mit olan Carmen’nin hangi Yunan ve Roma mitlerinin özelliklerini taşıdığı irdelenecektir. Carmen isimli çingenenin hikâyedeki karakteristik özelliklerine bakarak bu mitlerle ilişkisini bulmaya çalışacağız.
Ayrıca devlet ideolojisine bağlı bir yazar olan Mérimée’nin o dönemdeki erkeklerin “femme fatale” korkusunun bu hikâyede nasıl ele alındığı işlenecektir. Carmen hikâyesinde öne çıkan bazı ana temaları da inceleyerek, köklere bağlılık ve köklerden kopuş gibi o dönemin yazarlarından olan Maurice Barrès gibi milliyetçi yazarların Mérimée’nin yazını üzerindeki etkilerini ve bu temaları Carmen’de inleyeceğiz. Dominique Maingueneau’nun Carmen: Les racines d’un mythe isimli kitabını göz önünde bulundurarak, Carmen mitinin opera ile nasıl mit hâline dönüştüğü incelenecektir.