bluuebunny/crossref_metadata_2025 huggingface dataset:
Sustainable Wheels of Fortune: Understanding the Asymmetric Bond between Green Finance and Electric Vehicle Adoption
Authors: Zhao Yizhou , Ali Sajid , Nazar Raima , Anser Muhammad Khalid
Published: September 2024

Over the past few years, there has been a growing convergence of energy and environmental challenges globally, necessitating decisive actions. In response to these imperatives, countries have embraced electric vehicles as a transformative solution. This study probes the connection between green finance and electric-vehicle adoption in the top 10 economies with the greatest stock of electric vehicles. Previous investigations employing panel-data tools established consistent findings about the green-finance/electric-vehicle nexus. However, some countries exhibit distinct relationships. Using the quantile-on-quantile methodology, we analyze the time-series interdependence within individual countries, providing insights into the variables’ asymmetric association. The findings show that green finance positively influences the electric-vehicle stock in certain economies, specifically at distinct points within the data distribution, each characterized by its unique traits. The findings emphasize the significance of green finance measures in promoting widespread electric-vehicle adoption, contributing to environmental sustainability, and fostering a shift toward low carbon consumption.
Arthroscopic Centralization of the Medial Meniscus Reduces Load on a Posterior Root Repair Under Dynamic Varus Loading: A Biomechanical Investigation
Authors: Deichsel Adrian , Peez Christian , Raschke Michael J. , Richards R. Geoff , Gueorguiev Boyko , Zderic Ivan , Herbst Elmar , Kittl Christoph
Published: September 2024

Background:

In addition to the integrity of the meniscal hoop function, both the anterior and posterior meniscus roots as well as the meniscotibial and meniscofemoral ligaments are crucial in restraining meniscal extrusion. However, the interaction and load sharing between the roots and these peripheral attachments (PAs) are not known.

Purposes:

To investigate the influence of an insufficiency of the PAs on the forces acting on a posterior medial meniscus root repair (PMMRR) in both neutral and varus alignment and to explore whether meniscal centralization reduces these forces.

Study Design:

Controlled laboratory study.

Methods:

In 8 fresh-frozen human cadaveric knees, an arthroscopic transosseous root repair (step 1) was performed after sectioning the posterior root of the medial meniscus. The pull-out suture was connected to a load cell to allow measurement of the forces acting on the root repair. A medial closing-wedge distal femoral osteotomy was performed to change the mechanical axis from neutral to 5° of varus alignment. The meniscus was completely released from its PAs (step 2), followed by transosseous arthroscopic centralization (step 3). Each step was tested in both neutral and varus alignment. The specimens were subjected to nondestructive dynamic varus loading under axial compression of 300 N in 0°, 15°, 30°, 45°, and 60° flexion. The changes in force acting on the PMMRR were statistically analyzed using a mixed linear model.

Results:

Axial loading in neutral alignment led to an increase of the force of root repair of 3.1 ± 3.1 N (in 0° flexion) to 6.3 ± 4.4 N (in 60° flexion). In varus alignment, forces increased significantly from 30° (3.5 N; 95% CI, 1.1-5.8 N; P = .01) to 60° (7.1 N; 95% CI, 2.7-11.5 N; P = .007) flexion, in comparison with neutral alignment. Cutting of the PAs in neutral alignment led to a significant increase of root repair forces in all flexion angles, from 7.0 N (95% CI, 1.0-13.0 N; P = .02) to 9.1 N (95% CI, 4.1-14.1 N; P = .003), in comparison with the intact state. Varus alignment significantly increased the forces in the cut states from 4.8 N (95% CI, 1.0-8.5 N; P = .02) to 11.1 N (95% CI, 4.2-18.0 N; P = .006) from 30° to 60° flexion, in comparison with the neutral alignment. Arthroscopic centralization led to restoration of the native forces in both neutral and varus alignment, with no significant differences between the centralized and intact states.

Conclusion:

An insufficiency of the PAs of the medial meniscus, as well as varus alignment, led to increased forces acting on a PMMRR. These forces were reduced via an arthroscopic meniscal centralization.

Clinical Relevance:

Performing arthroscopic meniscal centralization concomitantly with PMMRR may reduce failure of the repair by reducing the load of the root.
A mini-review for identifying future directions in modelling heating values for sustainable waste management
Authors: Wang Dan , Tang Yu-Ting , He Jun , Robinson Darren , Yang Wanqin
Published: September 2024

Global estimations suggest energy content within municipal solid waste (MSW) is underutilized, compromising efforts to reduce fossil CO2 emissions and missing the opportunities for pursuing circular economy in energy consumption. The energy content of the MSW, represented by heating values (HVs), is a major determinant for the suitability of incinerating the waste for energy and managing waste flows. Literature reveals limitations in traditional statistical HV modelling approaches, which assume a linear and additive relationship between physiochemical properties of MSW samples and their HVs, as well as overlook the impact of non-combustible substances in MSW mixtures on energy harvest. Artificial intelligence (AI)-based models show promise but pose challenges in interpretation based on established combustion theories. From the variable selection perspectives, using MSW physical composition categories as explanatory variables neglects intra-category variations in energy contents while applying environmental or socio-economic factors emerges to address waste composition changes as society develops. The article contributes by showing to professionals and modellers that leveraging AI technology and incorporating societal and environmental factors are meaningful directions for advancing HV prediction in waste management. These approaches promise more precise evaluations of incinerating waste for energy and enhancing sustainable waste management practices.
Uncovering pathways towards sustainable transportation: Investigating factors influencing societal acceptance of end-of-life vehicle management in Indonesia
Authors: Sitinjak Charli , Simic Vladimir , Babaee Tirkolaee Erfan , Bacanin Nebojsa , Simanullang Wiyanti Fransisca , Fajar Rizqon
Published: September 2024

Addressing the critical environmental challenge of end-of-life vehicle (ELV) management in Indonesia’s transportation industry, this study investigates the complex interplay between societal factors and technical adoption. We use a comprehensive survey and path analysis to investigate the relationships between demographic characteristics (gender, age, income and education) and ELV acceptance, revealing complex preferences and concerns across several population groups. Comparative analyses with previous research reveal gender-specific inequities and age-related problems, emphasizing the importance of customized measures. Our findings indicate that environmental concerns exhibit a significant positive relationship with community acceptance (path coefficient = 0.426, p < 0.001). Moreover, technological familiarity (path coefficient = 0.352, p < 0.001) and infrastructure availability (path coefficient = 0.518, p < 0.001) demonstrate noteworthy positive associations, emphasizing the role of knowledge and accessible infrastructure in promoting acceptance. Conversely, the cost of adoption exhibits a negative relationship with societal acceptance (path coefficient = −0.269, p < 0.001), suggesting potential challenges that must be addressed. Mediation analysis uncovers the mediating roles of information exposure, perceived safety, as well as convenience and accessibility. Total effects analysis validates the collective influence of crucial factors while acknowledging the potential hindrance posed by the cost of adoption. Our findings contribute to inclusive policies and initiatives for sustainable ELV practices, offering insights to address a critical environmental issue in Indonesia. Although acknowledging limitations in scope and methodology, our research advances the discourse on sustainable transportation transitions and guides strategies to promote responsible ELV management in pursuing a greener and more socially equitable future.
Metallic and metallic oxide nanoparticles toxicity primarily targets the mitochondria of hepatocytes and renal cells
Authors: Jarrar Bashir , Almansour Mansour , Al-Doaiss Amin , Lee Shiou Yih , Melhem Walid , Jarrar Qais , Sewelam Amal
Published: September 2024

Nanoparticles (NPs) are utilized in various applications, posing potential risks to human health, tissues, cells, and macromolecules. This study aimed to investigate the ultrastructural alterations in hepatocytes and renal tubular cells induced by metallic and metal oxide NPs. Adult healthy male Wistar albino rats ( Rattus norvegicus) were divided into 6 ( n = 7) control and 6 treated groups ( n = 7). The rats in the treated groups exposed daily to silver NPs, gold NPs, zinc oxide NPs, silicon dioxide NPs, copper oxide NPs, and ferric oxide NPs for 35 days. The members of the control group for each corresponding NPs received the respective vehicle. Liver and kidney tissue blocks from all rats were processed for Transmission Electron Microscopy (TEM) examinations. The hepatocytes and renal tubular cells of all NPs-treated rats demonstrated mitochondrial ultrastructural alterations mainly cristolysis, swelling, membrane disruption, lucent matrices, matrices lysis, and electron-dense deposits. However, other organelles demonstrated injury but to a lesser extent in the form of shrunken nuclei, nuclear membrane indentation, endoplasmic reticulum fragmentation, cellular membranes enfolding, brush border microvilli disruption, lysosomal hyperplasia, ribosomes dropping, and peroxisome formation. One may conclude from the findings that the hepatocytes and the renal tubular cells mitochondria are the main targets for nanoparticles toxicity ending in mitochondrial disruption and cell injury. Further studies taking into account the relation of mitochondrial ultrastructural damage with a weakened antioxidant defense system induced by chronic exposure to nanomaterials are needed.
Acute Changes in Liver Function Tests During Initiation of Ketogenic Diet
Authors: Katyayan Akshat , Nayak Anuranjita , Diaz-Medina Gloria , Handoko Maureen , Riviello James John
Published: September 2024

Background

Ketogenic diet is an effective therapy for patients with medically refractory epilepsy. It is generally well tolerated, with the most common side effects being gastrointestinal. Hepatic toxicity has been described as an uncommon side effect of ketogenic diet, usually with long-term use. However, there are limited data to implicate ketogenic diet in acute liver toxicity.

Methods and results

We analyzed all patients who underwent elective inpatient ketogenic diet initiation at our institution from June 2019 to June 2022. Of the 25 patients reviewed, we found 6 patients who showed acute, asymptomatic changes in liver function tests during initiation, in both hepatocellular and cholestatic patterns. Two patients stopped the ketogenic diet acutely and 3 patients continued ketogenic diet with changes in medications and/or addition of choline—all patients had improvement and normalization of liver function tests in the short term. One patient had acute normalization of chronically elevated liver function tests on ketogenic diet initiation.

Conclusion

Ketogenic diet can cause acute changes in liver function tests during initiation of ketogenic diet, with both hepatocellular and cholestatic patterns, with and without the concurrent use of hepatotoxic medications. In most patients, ketogenic diet can be continued successfully by making changes to medications or addition of choline.
Recognition and Management of Delirium in the Neonatal Intensive Care Unit: Case Series From a Single-Center Level 4 Intensive Care Unit
Authors: Dornette Stacey , Deptola Stephen , Hemmann Brianna , Venkatesan Charu , Cortezzo DonnaMaria E.
Published: September 2024

Delirium often goes unrecognized in neonates and children because of lack of experience in evaluating behavior and cognition, insufficient awareness of the prevalence, and nondistinctive symptoms in this population. Although there are increasing reports of the presence of delirium in neonates, there are few data to guide the pharmacologic treatment in this population. In this retrospective single-center case series, we present our experience using quetiapine to treat delirium in 9 medically complex neonates. Based on an extensive literature review, expert opinion, and institutional experience, we propose an approach for monitoring and treating delirium in neonates and infants.
Prevalence and Correlates of Dating Violence Victimization Among a U.S.-Based Sample of Autistic Youth
Authors: Cusano Julia , Graham Holmes Laura , Caplan Reid , Rothman Emily F.
Published: September 2024

Dating violence victimization is a pervasive public health problem that affects individuals of all age groups, but it holds particular significance during adolescence due to the potential long-term consequences on an individual’s physical and psychological well-being, and potential influence on the health of adult relationships. Although there is now ample research on the topic of adolescent dating violence prevalence, risk factors, and consequences, to our knowledge, only four studies have assessed dating violence victimization among autistic youth. The current study was designed to investigate the prevalence of, and risk markers for, dating violence victimization among autistic youth. Specifically, the study had two aims: (a) to estimate the prevalence of dating violence victimization among autistic youth in a U.S.-based sample and (b) to identify correlates of dating violence for autistic youth, which include sociodemographic, mental health, and alcohol-related variables. We found that among participants who were in a romantic relationship in the past year, autistic participants were not any less likely to experience dating violence victimization compared to their non-autistic counterparts (40.7% for autistic youth vs. 38.0% for non-autistic youth). In addition, findings from the current study demonstrate the significant relationships between dating violence victimization and consequences of alcohol use, loneliness, and anxiety among autistic youth. Existing studies, in addition to the results of the current study, suggest the need for tailored dating violence prevention, support, and intervention to support the overall well-being of autistic youth.
Associations Between Weight Perception and Weight Status With Perceptions of the Body Positivity Movement
Authors: Rupp Kristie , McCoy Stephanie M.
Published: September 2024

Purpose

To explore the relationships between weight status, weight perceptions, and perceptions of the body positivity movement on social media.

Design

Cross-sectional.

Setting

Online through the Qualtrics platform.

Subjects

Participants (N = 521; mean 26.6 ± 5.1 years) were recruited using Qualtrics online panels.

Measures

The study survey included questions about participant demographics, weight status, and weight perception. Subjects rated 6 study-specific viewpoint questions about the body positivity movement on a 5pt Likert scale.

Analysis

Multinomial logistic regression models adjusted for relevant confounders assessed the associations between objective weight status, perceived weight status, and perceptions of the body positivity movement.

Results

Objective weight status was not associated with perceptions of the body positivity movement. Perceptions of weight status were associated with perceptions of the body positivity movement in young women, with those that perceived themselves as overweight more likely (OR = 1.67, P < 0.05) to disagree with the statement that “the body positivity makes people less likely to lose weight.”. However, young women that perceived themselves as having a lower weight status were less likely (OR = 0.54, P < 0.05) to agree with the statement that “the body positivity movement empowered women” as well as “being inclusive of people of all sizes” (OR = 0.56, P < 0.05).

Conclusion

Weight perception, rather than objective weight status, may be a stronger predictor of weight bias and views of the body positivity movement.
Human-robot collaborative assembly task planning for mobile cobots based on deep reinforcement learning
Authors: Hou Wenbin , Xiong Zhihua , Yue Ming , Chen Hao
Published: September 2024

Human-Robot Collaborative Assembly (HRCA) offers a novel solution to improve manual-based assembly manufacturing processes. However, the existing HRCA task planning approaches are limited in several aspects, such as inability to be applied effectively to mobile cobots with diverse workspaces and varying skill sets, as well as struggle in meeting the requirements of complex task structures and high-dimensional state spaces. In this paper, an interactive HRCA task planning framework based on finite Markov Decision Process (MDP) is presented, formalizing the Reinforcement Learning (RL) problem. To leverage the mobile and operational advantages of mobile cobots, a Multi-Attribute Hierarchical Task Network (MA-HTN) that enables efficient task decomposition and attribute representation is introduced. Additionally, considering state changes during assembly processes and utilizing Deep Reinforcement Learning (DRL) for handling high-dimensional decision problems, a universal DRL solving environment executed within unit time is constructed. This solving environment is based on a four-channel state diagram capable of reflecting high-dimensional state information that can be directly converted into digital tensor input for neural networks. Furthermore, to address frequent episode restarts in Deep Q-Network (DQN) algorithm and optimize task completion duration, a revival mechanism along with its enhanced algorithm are proposed. Finally, through an automobile fender bracket assembly scenario and an additional case study, the effectiveness of proposed method under varying numbers of tasks and work units is validated.
Rapid motion planning of manipulator in three-dimensional space under multiple scenes
Authors: Liang Ruijun , Wang Junwei , Li Yang , Ye Wenhua , Leng Sheng
Published: September 2024

Most working scenes of industrial robots are static scenes and from a previous static scene to a current static scene is a multi-scene. Finding optimal paths with limited time is difficult for motion planning in a high-dimensional space or in multiple scenes. The low efficiency of motion planning of rapidly-exploring random tree star in high-dimensional spaces, low adaptability of global replanning to multiple scenes are addressed by proposing the local replanning based on goal dynamically-guiding rapidly-exploring random tree star (LR-GD-RRT*). The algorithm contributes to fast path tree exploration and multi-scene motion planning. For path tree exploration, sampling points heuristically generating and new nodes growth by goal dynamically-guiding are proposed to reduce the blind and ineffective searches. Moreover, dynamic adjustment of size of new node neighborhood according to density of the obstacles is proposed to search for more neighbor nodes to optimize the path and also to reduce ineffective computation to improve efficiency. For multi-scene, three steps of trimming, re-exploration, and reconnection for local replanning are proposed. For path tree exploration, simulations in 2D plane, 3D space, and the manipulator show that GD-RRT* improves convergence speed, shortens path length and search time, compared with RRT*. For multi-scene, simulations in 3D space and with the manipulator show that the local replanning of the current scene has both lower path cost and higher planning efficiency compared with the global replanning of the previous scene. Motion of the six-degree-of-freedom robot end in a real scene also verifies the effectiveness of the LR-GD-RRT*.
Parameter effects on performance of piezoelectric wind energy harvesters based on the interaction between vortex-induced vibration and galloping
Authors: Yang Xiaokang , Niu Bo , He Kui , Liu Yahui , Xie Ruijie , Xu Bingke
Published: September 2024

Our previous research experimentally validated that the interaction between vortex-induced vibration and galloping is an effective method for enhancing the performance of piezoelectric wind energy harvesters under low wind speed conditions. We proposed a distributed-parameter electromechanical coupling model as well. This study aims to investigate the effects of various parameters and optimize the performance of VIV-galloping interactive piezoelectric wind energy harvesters. Initially, we assessed the applicability of the model under different circuit and aerodynamic force conditions and discussed boundary and convergence conditions by replicating previous results. Further, simulations were performed to analyze the effects of the structural parameters of the bluff body and piezoelectric beam. The width or depth of the bluff body significantly influenced the low critical wind speed, interactive occurrence, and electrical output. To achieve a balance between material cost and electrical benefit, we recommend positioning the electrode length from the fixed end with a coverage ratio of at least 60%. Additionally, the output power is highly sensitive to the piezoelectric beam length, but reducing it results in a higher natural frequency and critical wind speed. We fabricated and tested four prototypes, which have demonstrated significantly higher power densities compared with previously reported values at the same wind speed.
Anisogrid lattice structure in thermoplastic composite by filament gun deposition
Authors: Quadrini Fabrizio , Santoro Daniele , Santo Loredana
Published: September 2024

A new method to manufacture thermoplastic composite parts has been used to produce anisogrid lattice structures. Filament gun deposition consists of a hot-melt gun loaded with narrow thermoplastic prepreg tapes. Anisogrid lattice structures have been prototyped with 3 different geometries and 5 different numbers of layers (from 4 to 8) by using a metallic pattern and E-glass/polypropylene prepregs. Scanning calorimetry and bending tests of multi-layer samples have been used to characterize thermoplastic prepregs. Anisogrid lattice structures have been tested under tensile loads. A finite element model has been used to predict mechanical stiffness of these structures by using material properties coming from the sample characterization. Numerical models have been developed with a batch-type parametric approach to rapidly evaluate the combined effect of geometric and material parameters. A good agreement has been found between experimental and numerical data with an average difference about 4%.
Scenario-aware clustered federated learning for vehicle trajectory prediction with non-IID data
Authors: Tao Liang , Cui Yangguang , Zhang Xiaodong , Shen Wenfeng , Lu Weijia
Published: September 2024

In recent years, Federated Learning (FL) has attracted much attention in Vehicle Trajectory Prediction (VTP) as it can resolve the critical issues of insufficient data, data privacy, and training efficiency. However, compared with centralized training, the model trained by FL may have insufficient prediction performance. This important issue comes from a statistical heterogeneity distribution of the local data in the participating clients, that is, non-IID. Therefore, this paper introduces a Clustered Federated Learning (CFL) approach for the VTP model to mitigate the influence of non-IID data. The proposed approach consists of federated trajectory clustering and federated VTP model training. In federated trajectory clustering, the optimal trajectory scenario discriminator is produced using federated K-means clustering without direct access to private data. In the federated VTP model training, multiple VTP models for specific trajectory scenarios are trained to deal with the influence of non-IID data. Experimental results reveal that our approach outperforms the state-of-the-art FL method on both NGSIM and HighD datasets, achieving up to 13.82% convergence acceleration and 12.47% RMSE reduction.
Multi-fidelity multidisciplinary meta-model based optimization of a slender body with fins
Authors: Noureddine Saidi , Eddine Derbal Salh , Magrini Andrea , Smail Khalfallah , Mahfoudh Cerdoun , Benini Ernesto
Published: September 2024

Multidisciplinary design optimization (MDO) involving aero-elastic simulations still proves challenging for computational cost. This paper proposes a competitive cost-effective multi-fidelity MDO strategy based on two ideas. Firstly, a new multi-fidelity fluid-structure interaction model (MF-FSI) is proposed, allowing a considerable saving of the FSI simulation cost. Secondly, the optimization cost is further reduced using a meta-model approximation of the MF-FSI computations during optimization. Therefore, the MF-FSI model is validated on an experimental case of supersonic projectile fins. Then, it is combined with a meta-model-based optimization strategy (MBO) to improve the fins design. The constrained multi-objective problem aiming to maximize the lift-to-drag ratio and minimize the fin mass is solved using both high-fidelity (HFMDO) and multi-fidelity (MFMDO). The results showed that the proposed MFMDO strategy could produce the same optimal solutions as the HFMDO one with a 52% lower cost.
Testability modeling of aeroengine and analysis optimization method based on improved correlation matrix
Authors: Huang Shijie , Cai Jing , Dai Dingqiang
Published: September 2024

This paper aims to optimize the testability analysis method of aero-engines by presenting a testability modeling and an improved correlation matrix method. Because of strong coupling in aero-engines, the traditional testabilitsy modeling method based on graph theory is difficult to accurately express the relationship between faults and test points. Simulation technology can simulate actual work process of system. So this paper launches the research based on simulation model. Firstly, the gas path model is established according to the thermodynamic principle of aero-engines and accuracy of the model is verified. Secondly, common faults of gas path are selected. Affected parameters are obtained after injecting faults into the model, so as to obtain the relationship between faults and test points, that is, the correlation matrix. Then, after going through masses of simulations, it is found that the relationship between faults and test points can be divided into three categories: positive correlation, negative correlation and no correlation. The correlation matrix can be improved by diversifying its elements. During simulation, accuracy of the sensors are not considered. The correlation matrix is optimized with the accuracy of sensors in the gas path as a constraint, so that it is more in line with engineering practice. Finally, four testability characteristics and two testability metrics are defined, and the correlation matrix before and after improvement are analyzed and compared. It is found that the improved correlation matrix can isolate more faults on the premise of reducing test points, which proves the effectiveness of the proposed method.
Making rent: how forced migrant families access private rental housing in the Biqa’ Valley, Lebanon
Authors: Sender Hannah
Published: September 2024

The private rental market is a key provider of housing to forced migrants. This paper examines qualitative data from case study research in rapidly urbanizing towns in the Biqa’ Valley, Lebanon, focusing on Syrian forced migrants’ efforts to access housing through the local private rental sector. Building on literature about landlord–tenant relations and anthropological work on kin, I argue that rental agreements ought to be understood as both financial and social arrangements, which involve family members, landlords and middlemen ( shaweesh) in complex rental ecologies. I find that young Syrians are caught up in evolving financial and social obligations, which make inhabitation possible, but which perpetuate gendered and xenophobic forms of dispossession. I argue that humanitarian and development actors advocating for the right of forced migrants to settle in urban areas ought to avoid perpetuating reliance on an inequitable private rental sector.
Self-reliance programming in urban displacement: a pragmatic approach or a disillusionment?
Authors: McAteer Boel , Leeson Kellie
Published: September 2024

The promotion of self-reliance for refugees is a well-established policy priority within the global refugee support regime, hosting states and for many refugee-supporting organizations. For urban refugees, there is growing recognition of needs as well as potential for self-reliance support. However, meaningful investments in and commitment to the objective of self-reliance remain insufficient and critiques of the concept as an empty buzzword are many and substantial. This is a dialogue between Kellie Leeson and Boel McAteer, in which they elaborate on empirical examples of self-reliance programmes as either beneficial (Kellie) or counterproductive (Boel) to achieving genuine self-reliance. They conclude that self-reliance can only be wholly achieved alongside full refugee rights. They provide novel views of the concept by framing self-reliance as temporal and pragmatic on the one hand, and, on the other, by highlighting that the “self” in self-reliance often becomes unrealistically accentuated for urban refugees.
Development and comprehensive analyses of a hybrid solar–geothermal driven polygeneration system: Thermodynamic, exergoeconomic, and emergoenvironmental aspects
Authors: Fallahzadeh Maryam , Khoshgoftar Manesh Mohammad Hasan , Ghasemi Amir
Published: September 2024

The present research proposed an innovative polygeneration system that uses solar, geothermal, and natural gas energy to produce power, heat, steam, and freshwater. The system consists of a proton exchange membrane fuel cell, an organic Rankine cycle, and a multi-effect thermal desalination system. The study included thermodynamic, exergy, exergoeconomic, exergoenvironmental, emergy-based exergoeconomic, and emergy-based exergoenvironmental factors in its comprehensive evaluation of the system. Results underscored the financial aspect of the organic Rankine cycle and cogeneration system, incurring costs of 0.4518 $/s and 1.054 $/s respectively, while also highlighting the system's capability to produce 6 kg/s of freshwater. The environmental impact rates were quantified for the organic Rankine cycle and cogeneration system at 0.1417 and 0.4814 pts/s respectively, situating the system within its ecological context. Further, the study detailed the total efficiency and net power output of the organic Rankine cycle and cogeneration system, ranging between 32.45–33.51% and 43.25–45.83% for efficiency, and 56956–56322 kW and 50174–51898 kW for net power output r espectively, showcasing the system's operational capacity. A parametric analysis was also integral to the study, examining the impact of key parameters on the functionality of the proposed system, thereby providing a nuanced understanding of the system's performance under varying operational scenarios.
Genetic susceptibility and clinical features of CYP2D6 associated with systemic lupus erythematosus in a Chinese population
Authors: Luo Xiaoning , Du Juanhua , Zhao Jinjun , Fan Meida , Luo Xin , Zhao Peijin , Zheng Ping , Mo Liqian , Li Yilei
Published: September 2024

Objective

This study aims to explore possible susceptibility genes and clinical features for systemic lupus erythematosus (SLE) patients in a Chinese population.

Methods

Expanding on the results of a prior single-center observational study involving 60 systemic lupus erythematosus patients, a subsequent single-center prospective observational study was conducted on SLE patients undergoing treatment at Nanfang Hospital Affiliated to Southern Medical University from 2021 to 2023. The identification process for drug-related target genes entailed an extensive search across PharmGKB ( https://www.pharmgkb.org/ ), the Clinical Pharmacogenetics Implementation Consortium (CPIC),and PubMed literature databases, to pinpoint common drugs and target single nucleotide polymorphisms(SNPs)for SLE. Blood samples were individually collected and genotyped using MassARRAY® high-throughput nucleic acid mass spectrometry. Genotype frequency differences were assessed through Chi-square tests against both the larger East Asian population as well as kidney transplant recipients. Data collection relied on electronic medical records, encompassing demographic details(age, gender),medication regimens(hormones, NSAIDs, hydroxychloroquine, DMARDs, biologic agents, stomach medications, calcitriol, etc.),laboratory indicators(RF, Anti-CCP antibody, ESR, CRP, anti-ANA antibodies, dsDNA antibodies, anti-SM antibodies, S m. RNP antibodies, A LT, ALB, CR, UA, WBC, PLT, HGB, Ca, K, Glu, CHOL, TG, LDL-C, HDL-C) and lupus activity scores(SLEDAI-2K). Possible disease susceptibility genes were categorized, and SPSS26 software facilitated statistical analyses.

Results

The research encompassed a total of 137 SLE patients along with 50 SNPs. After conducting statistical analyses, it emerged that there existed significant disparities in CYP2D6 gene (rs1065852) distribution when compared against allele mutation rates within both East Asian populations ( p < .05) and kidney transplant patients( p < .05). Wild-type gene (GG) constituted 14% of cases while mutant gene (GA + AA) constituted 86%. Allele mutation rate (A63.6%) was significantly higher among SLE patients (RR = 0.802; p = .0355). Furthermore, the variant rs1065852 genotype (GA + AA) demonstrated significant associations with lower CRP levels, higher HGB levels, and higher HDL-C levels ( p < 0 0.05).

Conclusion

The metabolic enzyme CYP2D6 may be used as susceptibility gene for predicting systemic lupus erythematosus and are correlated with CRP and other indicators.
Impact of Acquired Brain Injury on Quality of Life
Authors: Dua Sharad , Kumar Rita , Prasannanshu  , Narang Karanjit Singh
Published: September 2024

Background

An injury to the brain affects a person in some or all cognitive, emotional, behavioural and physical domains impacting quality of life. Quality of life is essential to well-being and optimum functioning of a person in daily life. It is influenced by various individual and social aspects like physical, psychological, social relationships and environment. This article discusses an overview of impact of acquired brain injury on quality of life.

Purpose

This article aims to create an awareness of the nature of brain injury, factors impacting quality of life, and inter-relationships amongst them which can have implications for clinical rehabilitation.

Conclusion

An acquired brain injury is a life-changing event for the affected person and the family. It is globally considered a national burden. As compared to the developed countries, the availability and access to social determinants of health is low in the underdeveloped, and developing countries. An awareness of the nature of brain injury, the prognosis, available approaches to treatment can enable simple cost-effective psychosocial interventions to complement overall rehabilitation plan.
Locked-in to Dirty Fuel for Cooking: A Micro-Ethnographic Study in a Rural Area in Nusa Tenggara Timur, Indonesia
Authors: Astuti Septin Puji , Prasetiyawan Arian Agung , Margarena Agung Novianto
Published: September 2024

Ensuring sufficient access to clean and safe energy is a pre-requisite for enhancing the quality of human life. However, in some regions, such as Pitai village in Nusa Tenggara Timur, East Indonesia, people face challenges in accessing safe and clean energy, leading to the problem of energy poverty. Despite the government’s introduction of LPG in 2007, many households in Pitai continue to rely on firewood for cooking fuel. This article aims to investigate why most rural households in Pitai, Kupang and Nusa Tenggara Timur are still trapped in using dirty fuels like firewood, and how they perceived and accepted LPG after the national transition programme. To achieve this, a micro-ethnography study was conducted in Pitai village. The study’s results reveal that most of the community still prefers using firewood, which is more comfortable than LPG. Additionally, an inadequate supply of LPG, coupled with the abandonment of the firewood supply, has led to a lack of interest in adopting LPG. Consequently, the price of LPG remains higher than that of firewood, further discouraging its adoption. Addressing the issue of energy poverty in Pitai requires a comprehensive approach by the government involving providing adequate LPG supply and initiatives to raise awareness and change perceptions about LPG usage. By overcoming these challenges, the community can transition towards cleaner and safer energy sources, improving their overall quality of life. On the other hand, the government must address the accessibility and affordability of the LPG supply chain to inland areas, taking into account the challenges posed by the archipelagic nature of the country.
Youth Receiving Child Welfare Services and their Preferred Relationships With Their Service Providers
Authors: Khan Anam , Ungar Michael
Published: September 2024

Purpose: This study explores the experiences of youth receiving Child Welfare Services (CWS) in Nova Scotia, Canada and their preferred relationships with different service providers and how these relationships may promote or hinder their resilience at different levels of risk exposure. Method: Qualitative interviews with 23 youth (aged 14–19) were analyzed using grounded theory. Results: The analysis revealed two core categories, relationship building and mentoring relationship as well as supporting themes that were modelled into a theoretical understanding of three distinct relationship patterns (parent-like, peer-like, and professional) that youth seek from their service providers. Findings discuss the category relationship building, comprising of two themes—youth mobility and multiple service providers; followed by a discussion on the three mentoring relationships. Conclusion: Implications address how salient features from these patterns of youth–worker relationships can be effectively integrated into service delivery.
Bypassing Prescribers and Pharmacists: Online Purchasing of Semaglutide and Tirzepatide “For Research Purposes”
Authors: Belcourt Jordyn , Ly Priscilla , White C. Michael
Published: September 2024

Unscrupulous manufacturers provide consumers with ways to circumvent access controls by purchasing drug products outside the legitimate prescription drug supply chain. Manufacturers are selling vials containing semaglutide and tirzepatide to consumers without a prescription for “research purposes only” and/or “not for human consumption,” but frequently without the supplies and knowledge they would need to dissolve the active ingredient, draw it up into a syringe, and inject it into the body. Avoiding prescribers allows consumer access to products where the risk may outweigh the benefits and quality standards may not be met. It also makes it difficult to prevent drug interactions or perform adequate patient monitoring and follow-up.
The Costs of Voting and Voter Confidence
Authors: Atkeson Lonna Rae , McKown-Dawson Eli , Stein Robert M.
Published: September 2024

We revisit the effect of ballot access laws on voter confidence in the outcome of elections. Previous research found weak or no relationship between voter confidence and election laws regulating ballot access. We argue this non-finding is conditioned by partisanship. Democrats and Republicans view election laws through a partisan lens, which is especially triggered when coalitions lose. Republican voters see ballot restrictions as a means of securing the vote against fraud; Democratic voters see ballot restrictions as voter suppression. We maintain that the conditional partisan effect that election laws have on voter confidence is triggered or attenuated when partisans’ candidates lose elections. We find that in states where ballot access is costly, voter confidence among partisans and supporters of the losing Presidential candidate is significantly higher for Republicans and significantly lower for Democrats than their counterparts in states with less costly ballot access laws. These effects are greater for Republican than Democrats. We discuss the implications of our findings on election ecosystems and voter confidence.
Molecular Testing for EGFR Mutation in Moroccan NSCLC Patients: CHU Hassan II-Fez Experience
Authors: Boukansa Sara , Mouhrach Ismail , Agy Fatima El , Gamrani Sanaa , Bouguenouch Laila , Serraj Mounia , Amara Bouchra , Ouadnouni Yassine , Smahi Mohamed , Alami Badreeddine , Mellas Nawfel , Benbrahim Zineb , Fatemi Hinde El
Published: September 2024

Epidermal growth factor receptor ( EGFR) mutation screening in non-small cell lung cancer (NSCLC) is now used to guide treatment decisions to identify patients with EGFR positive mutations that predict response to EGFR tyrosine kinase inhibitors. This study aimed to explore with a prospective study the current testing practices and the predictive value of EGFR mutations in a series of 261 patients with NSCLC. EGFR mutation testing was conducted using 2 different assays: bidirectional Sanger sequencing of polymerase chain reaction (PCR) and real-time PCR on the Rotor-Gene Q instrument. Epidermal growth factor receptor mutation testing was performed for 261 patients with lung cancer. Exons 18 to 21 were successfully analyzed in 113 tumors by Direct sequencing and in 148 tumors by real-time PCR. The prevalence of positive EGFR-mutations in each method was 22.1% (N = 25) and 24.3% (N = 36), respectively ( P = .3). In total, EGFR mutations were detected in 59 patients among 261 patients with NSCLC. A statistically significant association between female sex, nonsmoking history, nonsolid major pattern, and a higher EGFR mutation frequency. In this study, we investigated clinicopathological differences between tumors harboring exon 19del and those harboring L858R. We did not find any significant differences between the 2 mutations and gender or smoking features, interestingly, the prevalence of patients aged >60 years was significantly higher in the L858R group than in the exon 19del group (81.8% vs 55.8%, P = .05). A significant association was observed between exon 19 deletions and the papillary major pattern, but no correlation was detected between exon 21 mutation and any histological pattern. This prospective study documented the real-world clinical testing of EGFR mutation in Moroccan NSCLC patients. Our experience confirms the need to develop standards-based guidelines for the routine performance and evaluation of EGFR testing to improve clinical care for this subset of lung cancer. On the other hand, our study demonstrated that tumors with exon 19 deletions and L858R harbor specific clinicopathological features in NSCLC.
Knowledge and Practice of Women With HIV on Cervical Cancer Prevention and Control and their Attributes to Utilize the Screening Services in Ethiopia: A Cross Sectional Study
Authors: Bogale Agajie Likie , Ali Jemal Haidar , Sherif Zaki A.
Published: September 2024

Background

Previous studies underscore the crucial link between awareness and timely cervical cancer screening and treatment, particularly among women of reproductive age. Yet, insights remain limited when it comes to women living with HIV in Addis Ababa. This study examined the knowledge and practices of these women regarding cervical cancer screening and treatment, illuminating the factors that both enable and hinder their uptake.

Methods

This cross-sectional study took place in six public hospitals in Addis Ababa, Ethiopia, involving 578 women with HIV. The recruitment spanned 10 months, from January 1st to October 31st, 2021. Trained clinicians utilized the Open Data Kit for data collection, ensuring real-time submission to the server. Statistical analysis was performed using SPSS version 25, employing descriptive and inferential statistics. The logistic regression model identified predictors of outcome variables, and open-ended questions were thematically narrated for qualitative insights.

Results

A notable 51.2% of women with HIV exhibited inadequate knowledge regarding cervical cancer prevention and control programs. Furthermore, a substantial 68.5% had never undergone cervical examination, citing reasons such as considering themselves healthy (49.6%), perceiving the examination as painful (28.4%), and feeling shy to undergo screening (23.3%). Notably, participants with non-formal education were 70% less likely to possess knowledge about cervical cancer prevention and control (AOR = 0.30; 95% CI = 0.13-0.71). Income emerged as an independent predictor for both knowledge and practice in women’s approach to cervical cancer prevention and control ( P < 0.05). Additionally, occupation and duration of HIV diagnosis independently predicted practice, even after adjusting for confounding factors.

Conclusion

Half of the participating HIV-positive women lacked adequate awareness about cervical cancer prevention and control, underscoring the urgent need for comprehensive awareness initiatives tailored to this population. Relevant ministries, health care providers, and advocacy groups must collaborate to implement targeted education programs, utilizing diverse channels like community outreach, health care settings, and media campaigns.
DDR1 is a Novel Biomarker and Potential Therapeutic Target for the Combination Treatment of Liver Hepatocellular Carcinoma
Authors: Li Tianxing , Hu Hao , Song Yuhao , Shi Yihai , Hu Dingtao , Shen Weifeng , Ning Beifang
Published: September 2024

Aim

This study aimed to investigate the role of discoidin domain receptor tyrosine kinase 1 (DDR1) in liver hepatocellular carcinoma (LIHC) and to evaluate its prognostic value on patient response to combination therapy.

Methods

In the current retrospective study, we examined the protein expression of DDR1 in various cancers by standard immunohistochemical (IHC) methods and evaluated its clinical significance in LIHC personalized treatment. Multiple online databases, including The Cancer Genome Atlas (TCGA), TIMER, GEO, ROC Plotter, and Genomics of Drug Sensitivity in Cancer (GDSC), were used.

Results

DDR1 protein expression was higher in LIHC than in other nine examined cancer types. Additionally, DDR1 exhibited higher expression levels in adjacent normal tissues compared to HBs-positive LIHC tissues. Analysis at single-cell resolution revealed that DDR1 was expressed primarily in epithelial cells but not in stromal and immune cells, and DDR1 expression was lower in HBs-positive LIHC cells in comparison with normal hepatocytes. Correlation of DDR1 upregulation and sorafenib resistance was observed in the patient cohort. Moreover, DDR1 expression positively correlated with the expression of inflammatory response-related genes, ECM-related genes, and collagen formation-related genes, but negatively correlated with the infiltration of CD8+ T cells, NK cells, and dendritic cells in LIHC.

Conclusions

Our findings suggest that DDR1 expression might be induced by collagen production-related cellular events involved in liver injury and repair, and that DDR1 overexpression might contribute to the resistance to LIHC targeted therapy and immunotherapy, highlighting DDR1 as a potential prognostic biomarker and therapeutic target.