bluuebunny/crossref_metadata_2025 huggingface dataset:
Time-Varying Pseudorandom Disturbed Pattern Generation Algorithm for Track Circuit Equipment Testing
Authors: Chen Xiaoming , Wang Zhixuan , Yu Zhiyang , Chui Hsiang-Chen
Published: May 2022

To improve the test accuracy and fault coverage of high-speed railway-related equipment boards, a time-varying pseudorandom disturbance algorithm based on the automatic test pattern generation technology in chip testing is proposed. The algorithm combines the pseudorandom pattern generation algorithm with the deterministic pattern generation D algorithm. The existing pseudorandom number generation method usually requires random seeds to generate a series of pseudorandom numbers. In this algorithm, the system timer is used as the random seed to design a pseudorandom pattern generation method of time-varying seed to improve the randomness of pseudorandom pattern generation. In addition, in combination with the D algorithm, this work proposes a new switching logic between two algorithms by counting invalid pattern proportions. When the algorithm is applied to track a circuit netlist, the fault coverage can reach near 100%. However, the large-scale circuit fault coverage cannot easily reach 100%. The test results for the standard circuits of different sizes show that at the same time, compared with the independent pattern generation methods, the proposed algorithm can improve fault coverage by more than 50% and 30% and significantly improve the pattern generation efficiency. Therefore, it can be used perfectly in the subsequent construction of high-speed railway equipment test platforms.
Construction of Conceptual Prospecting Model Based on Geological Big Data: A Case Study in Songtao-Huayuan Area, Hunan Province
Authors: Liu Chang , Chen Jianping , Li Shi , Qin Tao
Published: May 2022

With the era of big data, the prediction and evaluation of geological mineral resources have gradually entered into a new stage from digital prospecting to intelligent prospecting. The theoretical method of big data mining can contribute to deep mineral resource prediction and evaluation. This paper extracts ore-causing and ore-caused anomaly information based on text intelligent mining technology, and constructs a regional conceptual prospecting model based on geological prospecting big data. First, we set up a corpus based on text big data discovery and preprocessing technology. Second, we used CNN multiple scale text classification technology to analyze geological text data from the two main aspects: ore-causing anomalies and ore-caused anomalies. Third, we used a statistical method to analyze the semantic links between content-words, and we constructed chord diagrams and ternary diagrams to visualize the content-words and their links. Finally, we constructed a regional conceptual prospecting model based on the knowledge graphs.
A Kinetic Model for Size Reduction in a Pilot Scale Tower Mill: Model Verification
Authors: Austin Leonard G. , Schneider Claudio L.
Published: May 2022

Mark Duffy produced a complete set of grinding data on a pilot-scale tower mill. Here these data are analyzed in terms of grinding kinetics. The results show that the data can be fitted with a simple first-order breakage model, which is not normally observed in any grinding system, including other types of grinding machines such as tumbling ball mills and rod mills. The model has only two parameters, making it possible to determine the parameters using simple search methods. The results show that larger particles break faster than smaller particles, as is usually observed in all mills. Statistical analysis of the data showed that one of the parameters could be fixed for seven of the nine tests.
Pedicularis resupinata Extract Prevents Depressive-like Behavior in Repeated Corticosterone-Induced Depression in Mice: A Preliminary Study
Authors: Lim Dong Wook , Han Daeseok , Lee Changho
Published: May 2022

Excessive corticosterone (CORT), resulting from a dysregulated hypothalamic–pituitary–adrenal (HPA) axis, is associated with cognitive impairment and behavioral changes, including depression. In Korean oriental medicine, Pedicularis resupinata is used for the treatment of inflammatory diseases such as rheumatoid arthritis. However, the antidepressant properties of P. resupinata have not been well characterized. Here, the antidepressant-like effects of P. resupinata extract (PRE) were evaluated in terms of CORT-induced depression using in vivo models. HPLC confirmed that acteoside, a phenylethanoid glycoside, was the main compound from PRE. Male ICR mice (8 weeks old) were injected with CORT (40 mg/kg, i.p.) and orally administered PRE daily (30, 100, and 300 mg/kg) for 21 consecutive days. Depressive-like behaviors were evaluated using the open-field test, sucrose preference test, passive avoidance test, tail suspension test, and forced swim test. Treatment with a high dose of PRE significantly alleviated CORT-induced, depressive-like behaviors in mice. Additionally, repeated CORT injection markedly reduced brain-derived neurotrophic factor levels, whereas total glucocorticoid receptor (GR) and GR phosphorylation at serine 211 were significantly increased in the mice hippocampus but improved by PRE treatment. Thus, our findings suggest that PRE has potential antidepressant-like effects in CORT-induced, depressive-like behavior in mice.
Efficient Synthesis of 2-Aminopyridine Derivatives: Antibacterial Activity Assessment and Molecular Docking Studies
Authors: Kibou Zahira , Aissaoui Nadia , Daoud Ismail , Seijas Julio A. , Vázquez-Tato María Pilar , Klouche Khelil Nihel , Choukchou-Braham Noureddine
Published: May 2022

A new and suitable multicomponent one-pot reaction was developed for the synthesis of 2-amino-3-cyanopyridine derivatives. Background: This synthesis was demonstrated by the efficient and easy access to a variety of substituted 2-aminopyridines using enaminones as key precursors under solvent-free conditions. Methods: A range of spectroscopic techniques was used to determine and confirm the chemical structures (FTIR, 1H NMR, 13C NMR). The antimicrobial potency of synthesized compounds (2a–d) was tested using disk diffusion assays, and the Minimum Inhibitory Concentration (MIC) for the active compounds was determined against a panel of microorganisms, including Gram-positive and Gram-negative bacteria and yeasts. Moreover, a docking analysis was conducted by Molecular Operating Environment (MOE) software to provide supplementary information about the potential, as well as an ADME-T prediction to describe the pharmacokinetic properties of the best compound and its toxicity. Results: The results of the antimicrobial activity indicated that compound 2c showed the highest activity against Gram-positive bacteria, particularly S. aureus and B. subtilis whose MIC values were 0.039 ± 0.000 µg·mL−1. The results of the theoretical study of compound 2c were in line with the experimental data and exhibited excellent antibacterial potential. Conclusions: On the basis of the obtained results, compound 2c can be used as an antibacterial agent model with high antibacterial potency.
Three-Dimensional Bioprinting of Decellularized Extracellular Matrix-Based Bioinks for Tissue Engineering
Authors: Zhang Chun-Yang , Fu Chao-Ping , Li Xiong-Ya , Lu Xiao-Chang , Hu Long-Ge , Kankala Ranjith Kumar , Wang Shi-Bin , Chen Ai-Zheng
Published: May 2022

Three-dimensional (3D) bioprinting is one of the most promising additive manufacturing technologies for fabricating various biomimetic architectures of tissues and organs. In this context, the bioink, a critical element for biofabrication, is a mixture of biomaterials and living cells used in 3D printing to create cell-laden structures. Recently, decellularized extracellular matrix (dECM)-based bioinks derived from natural tissues have garnered enormous attention from researchers due to their unique and complex biochemical properties. This review initially presents the details of the natural ECM and its role in cell growth and metabolism. Further, we briefly emphasize the commonly used decellularization treatment procedures and subsequent evaluations for the quality control of the dECM. In addition, we summarize some of the common bioink preparation strategies, the 3D bioprinting approaches, and the applicability of 3D-printed dECM bioinks to tissue engineering. Finally, we present some of the challenges in this field and the prospects for future development.
Surface Modification Strategy for Enhanced NO2 Capture in Metal–Organic Frameworks
Authors: Raptis Dionysios , Livas Charalampos , Stavroglou George , Giappa Rafaela Maria , Tylianakis Emmanuel , Stergiannakos Taxiarchis , Froudakis George E.
Published: May 2022

The interaction strength of nitrogen dioxide (NO2) with a set of 43 functionalized benzene molecules was investigated by performing density functional theory (DFT) calculations. The functional groups under study were strategically selected as potential modifications of the organic linker of existing metal–organic frameworks (MOFs) in order to enhance their uptake of NO2 molecules. Among the functional groups considered, the highest interaction energy with NO2 (5.4 kcal/mol) was found for phenyl hydrogen sulfate (-OSO3H) at the RI-DSD-BLYP/def2-TZVPP level of theory—an interaction almost three times larger than the corresponding binding energy for non-functionalized benzene (2.0 kcal/mol). The groups with the strongest NO2 interactions (-OSO3H, -PO3H2, -OPO3H2) were selected for functionalizing the linker of IRMOF-8 and investigating the trend in their NO2 uptake capacities with grand canonical Monte Carlo (GCMC) simulations at ambient temperature for a wide pressure range. The predicted isotherms show a profound enhancement of the NO2 uptake with the introduction of the strongly-binding functional groups in the framework, rendering them promising modification candidates for improving the NO2 uptake performance not only in MOFs but also in various other porous materials.
Recent Developments in the Photochemical Synthesis of Functionalized Imidazopyridines
Authors: Tran Christine , Hamze Abdallah
Published: May 2022

Imidazopyridines constitute one of the most important scaffolds in medicinal chemistry, as their skeleton could be found in a myriad of biologically active molecules. Although numerous strategies were elaborated for imidazopyridine preparation in the 2010s, novel eco-compatible synthetic approaches have emerged, conscious of climate change concerns. In this framework, photochemical methods have been promoted to conceive this heterocyclic motif over the last decade. This review covers the recently published works on synthesizing highly functionalized imidazopyridines by light induction.
Transcriptome Profiling of HCT-116 Colorectal Cancer Cells with RNA Sequencing Reveals Novel Targets for Polyphenol Nano Curcumin
Authors: Azeez Hewa Jalal , Neri Francesco , Hosseinpour Feizi Mohammad Ali , Babaei Esmaeil
Published: May 2022

Colorectal cancer is one of the leading causes of cancer-related deaths worldwide. The gemini nanoparticle formulation of polyphenolic curcumin significantly inhibits the viability of cancer cells. However, the molecular mechanisms and pathways underlying its toxicity in colon cancer are unclear. Here, we aimed to uncover the possible novel targets of gemini curcumin (Gemini-Cur) on colorectal cancer and related cellular pathways. After confirming the cytotoxic effect of Gemini-Cur by MTT and apoptotic assays, RNA sequencing was employed to identify differentially expressed genes (DEGs) in HCT-116 cells. On a total of 3892 DEGs (padj < 0.01), 442 genes showed a log2 FC >|2| (including 244 upregulated and 198 downregulated). Gene ontology (GO) enrichment analysis was performed. Protein–protein interaction (PPI) and gene-pathway networks were constructed by using STRING and Cytoscape. The pathway analysis showed that Gemini-Cur predominantly modulates pathways related to the cell cycle. The gene network analysis revealed five central genes, namely GADD45G, ATF3, BUB1B, CCNA2 and CDK1. Real-time PCR and Western blotting analysis confirmed the significant modulation of these genes in Gemini-Cur-treated compared to non-treated cells. In conclusion, RNA sequencing revealed novel potential targets of curcumin on cancer cells. Further studies are required to elucidate the molecular mechanism of action of Gemini-Cur regarding the modulation of the expression of hub genes.
HPLC Determination of Colistin in Human Urine Using Alkaline Mobile Phase Combined with Post-Column Derivatization: Validation Using Accuracy Profiles
Authors: Papavasileiou Kalliopi , Tsiasioti Apostolia , Tzanavaras Paraskevas D. , Zacharis Constantinos K.
Published: May 2022

In this study, the development, validation, and application of a new liquid chromatography post-column derivatization method for the determination of Colistin in human urine samples is demonstrated. Separation of Colistin was performed using a core–shell C18 analytical column in an alkaline medium in order (i) to be compatible with the o-phthalaldehyde-based post-column derivatization reaction and (ii) to obtain better retention of the analyte. The Colistin derivative was detected spectrofluorometrically (λext/λem = 340/460 nm) after post-column derivatization with o-phthalaldehyde and N-acetyl cysteine. The post-column derivatization parameters were optimized using the Box–Behnken experimental design, and the method was validated using the total error concept. The β-expectation tolerance intervals did not exceed the acceptance criteria of ±15%, meaning that 95% of future results would be included in the defined bias limits. The limit of detection of the method was adequate corresponding to 100 nmol·L−1. The mean analytical bias (expressed as relative error) in the spiking levels was suitable, being in the range of −2.8 to +2.5% for both compounds with the percentage relative standard deviation lower than 3.4% in all cases. The proposed analytical method was satisfactorily applied to the analysis of the drug in human urine samples.
Revisiting the Chemistry of Vinylpyrazoles: Properties, Synthesis, and Reactivity
Authors: Silva Vera L. M. , Silva Artur M. S.
Published: May 2022

Vinylpyrazoles, also known as pyrazolyl olefins, are interesting motifs in organic chemistry but have been overlooked. This review describes the properties and synthetic routes of vinylpyrazoles and highlights their versatility as building blocks for the construction of more complex organic molecules. Concerning the reactivity of vinylpyrazoles, the topics surveyed herein include their use in cycloaddition reactions, free-radical polymerizations, halogenation and hydrohalogenation reactions, and more recently in transition-metal-catalyzed reactions, among other transformations. The current state of the art about vinylpyrazoles is presented with an eye to future developments regarding the chemistry of these interesting compounds. Styrylpyrazoles were not considered in this review, as they were the subject of a previous review article published in 2020.
Synthesis of Sugar and Nucleoside Analogs and Evaluation of Their Anticancer and Analgesic Potentials
Authors: Hussain Fahad , Rahman Fahad Imtiaz , Saha Poushali , Mikami Atsushi , Osawa Takashi , Obika Satoshi , Rahman S. M. Abdur
Published: May 2022

Chemical modification of sugars and nucleosides has a long history of producing compounds with improved selectivity and efficacy. In this study, several modified sugars (2–3) and ribonucleoside analogs (4–8) have been synthesized from α-d-glucose in a total of 21 steps. The compounds were tested for peripheral anti-nociceptive characteristics in the acetic acid-induced writhing assay in mice, where compounds 2, 7, and 8 showed a significant reduction in the number of writhes by 56%, 62%, and 63%, respectively. The compounds were also tested for their cytotoxic potential against human HeLa cell line via trypan blue dye exclusion test followed by cell counting kit-8 (CCK-8) assay. Compound 6 demonstrated significant cytotoxic activity with an IC50 value of 54 µg/mL. Molecular docking simulations revealed that compounds 2, 7, and 8 had a comparable binding affinity to cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. Additionally, the bridged nucleoside analogs 7 and 8 potently inhibited adenosine kinase enzyme as well, which indicates an alternate mechanistic pathway behind their anti-nociceptive action. Cytotoxic compound 6 demonstrated strong docking with cancer drug targets human cytidine deaminase, proto-oncogene tyrosine-protein kinase Src, human thymidine kinase 1, human thymidylate synthase, and human adenosine deaminase 2. This is the first ever reporting of the synthesis and analgesic property of compound 8 and the cytotoxic potential of compound 6.
Tunable Switching Behavior of GO-Based Memristors Using Thermal Reduction
Authors: Abujabal Muayad , Abunahla Heba , Mohammad Baker , Alazzam Anas
Published: May 2022

This work reports on the fabrication of a novel planar reduced graphene oxide (rGO) memristor (MR) device. For the first time in the literature, the MR tunable resistive switching behavior is controlled by the GO reduction time at a constant temperature. The device is fabricated using standard microfabrication techniques on a flexible cyclic olefin copolymer substrate (COC). Thermal reduction of the GO layer at low temperatures (100 °C) avoids the drawbacks of chemical reduction methods such as toxicity and electrode metal damage during fabrication, while allowing for fine-tuning of the MR’s switching behavior. The device has analog switching characteristics, with a range of different resistance states. By taking advantage of the slow nature of GO thermal annealing, the switching properties of the rGO memristors can be precisely controlled by adjusting the reduction period. At short annealing times (i.e., T < 20 h), the devices switch from high to low resistance states, while at longer annealing times the switching behavior is reversed, with the device switching from low to high resistance states (LRS to HRS). Resistive switching occurs as a result of the diffusion and removal of the oxygen functional groups in the GO film caused by Joule heating induced by the electric current. Complete electrical characterization tests are presented along with wettability and X-ray diffraction (XRD) tests. This work opens a new vision for realizing rGO-based MR devices with tunable switching properties, broadening the application horizon of the device.
Deposition of Nanosized Amino Acid Functionalized Bismuth Oxido Clusters on Gold Surfaces
Authors: Morgenstern Annika , Thomas Rico , Sharma Apoorva , Weber Marcus , Selyshchev Oleksandr , Milekhin Ilya , Dentel Doreen , Gemming Sibylle , Tegenkamp Christoph , Zahn Dietrich R. T. , Mehring Michael , Salvan Georgeta
Published: May 2022

Bismuth compounds are of growing interest with regard to potential applications in catalysis, medicine, and electronics, for which their environmentally benign nature is one of the key factors. One thing that currently hampers the further development of bismuth oxido-based materials, however, is the often low solubility of the precursors, which makes targeted immobilisation on substrates challenging. We present an approach towards the solubilisation of bismuth oxido clusters by introducing an amino carboxylate as a functional group. For this purpose, the bismuth oxido cluster [Bi38O45(NO3)20(dmso)28](NO3)4·4dmso (dmso = dimethyl sulfoxide) was reacted with the sodium salt of tert-butyloxycabonyl (Boc)-protected phenylalanine (L-Phe) to obtain the soluble and chiral nanocluster [Bi38O45(Boc–Phe–O)24(dmso)9]. The exchange of the nitrates by the amino carboxylates was proven by nuclear magnetic resonance, Fourier-transform infrared spectroscopy, as well as elemental analysis and X-ray photoemission spectroscopy. The solubility of the bismuth oxido cluster in a protic as well as an aprotic polar organic solvent and the growth mode of the clusters upon spin, dip, and drop coating on gold surfaces were studied by a variety of microscopy, as well as spectroscopic techniques. In all cases, the bismuth oxido clusters form crystalline agglomerations with size, height, and distribution on the substrate that can be controlled by the choice of the solvent and of the deposition method.
The Use of Diatomite as a Catalyst Carrier for the Synthesis of Carbon Nanotubes
Authors: Nazhipkyzy Meruyert , Nemkayeva Renata R. , Nurgain Araylim , Seitkazinova Aigerim R. , Dinistanova Balaussa K. , Issanbekova Almagul T. , Zhylybayeva Nurzhamal , Bergeneva Nurgul S. , Mamatova Gulnar U.
Published: May 2022

In this article, multiwalled carbon nanotubes (MWCNTs) have been synthesized on the surface of a diatomite mineral impregnated with transition metal salts using a propane-butane mixture in a chemical vapor deposition reactor at atmospheric pressure. The catalyst concentration and synthesis temperature have been varied in order to understand their effects on the formation of MWCNTs and their morphology. Diatomite was chosen as a catalyst carrier due to its elemental composition. It is mainly composed of amorphous silica, quartz and also contains such metals as Fe, K, Ca, Mn, Cr, Ti, and Zn, which makes it a promising material for use as a catalyst carrier when synthesizing carbon nanotubes (CNTs) by catalytic chemical vapor deposition (C-CVD). For the synthesis of carbon nanotubes by C-CVD on the surface of the diatomite, the following salts were used as a catalyst: CoCl2·6H2O; Ni(NO3)2·6H2O, and the concentrations of the solutions were 0.5; 1.0 and 1.5 M. Natural diatomite was characterized by X-ray diffraction analysis (XRD) and Scanning Electron Microscopy (SEM) analysis.
Nanostructures for Photonics and Optoelectronics
Authors: Torres-Costa Vicente
Published: May 2022

As microelectronic technology approaches the limit of what can be achieved in terms of speed and integration level, there is an increasing interest in moving from electronics to photonics, where photons and light beams replace electrons and electrical currents, which will result in higher processing speeds and lower power consumption [...]
Light Trapping of Inclined Si Nanowires for Efficient Inorganic/Organic Hybrid Solar Cells
Authors: Chen Shih-Hsiu , Kuo Kuan-Yi , Tsai Kun-Hung , Chen Chia-Yun
Published: May 2022

Light/matter interaction of low-dimensional silicon (Si) strongly correlated with its geometrical features, which resulted in being highly critical for the practical development of Si-based photovoltaic applications. Yet, orientation modulation together with apt control over the size and spacing of aligned Si nanowire (SiNW) arrays remained rather challenging. Here, we demonstrated that the transition of formed SiNWs with controlled diameters and spacing from the crystallographically preferred <100> to <110> orientation was realized through the facile adjustment of etchant compositions. The underlying mechanism was found to correlate with the competing reactions between the formation and removal of oxide at Ag/Si interfaces that could be readily tailored through the concentration ratio of HF to H2O2. By employing inclined SiNWs for the construction of hybrid solar cells, the improved cell performances compared with conventional vertical-SiNW-based hybrid cells were demonstrated, showing the conversion efficiency of 12.23%, approximately 1.12 times higher than that of vertical-SiNW-based hybrid solar cells. These were numerically and experimentally interpreted by the involvement of excellent light-trapping effects covering the wide-angle light illuminations of inclined SiNWs, which paved the potential design for next-generation optoelectronic devices.
Functionalized Mesoporous Silica as Doxorubicin Carriers and Cytotoxicity Boosters
Authors: Racles Carmen , Zaltariov Mirela-Fernanda , Peptanariu Dragos , Vasiliu Tudor , Cazacu Maria
Published: May 2022

Mesoporous silica nanoparticles (MSNs) bearing methyl, thiol or glucose groups were synthesized, and their encapsulation and release behaviors for the anticancer drug Doxorubicin (Dox) were investigated in comparison with nonporous homologous materials. The chemical modification of thiol-functional silica with a double bond glucoside was completed for the first time, by green thiol-ene photoaddition. The MSNs were characterized in terms of structure (FT-IR, Raman), morphology (TEM), porosity (nitrogen sorption–desorption) and Zeta potential measurements. The physical interactions responsible for the Dox encapsulation were investigated by analytic methods and MD simulations, and were correlated with the high loading efficiency of MSNs with thiol and glucose groups. High release at pH 5 was observed in most cases, with thiol-MSN exhibiting 98.25% cumulative release in sustained profile. At pH 7.4, the glucose-MSN showed 75.4% cumulative release, while the methyl-MSN exhibited a sustained release trend. The in vitro cytotoxicity was evaluated on NDHF, MeWo and HeLa cell lines by CellTiter-Glo assay, revealing strong cytotoxic effects in all of the loaded silica at low equivalent Dox concentration and selectivity for cancer cells. Atypical applications of each MSN as intravaginal, topical or oral Dox administration route could be proposed.
Interface Adhesion Property and Laser Ablation Performance of GAP-PET Double-Layer Tape with Plasma Treatment
Authors: Wang Sibo , Du Bangdeng , Xing Baoyu , Hong Yanji , Wang Ying , Du Baosheng , Zheng Yongzan , Ye Jifei , Li Chenglin
Published: May 2022

In the field of laser ablation micro-propulsion, the property of double-layer tape has significant impact on the propulsion performance. In this paper, low temperature plasma was used to treat the surface of polyethylene terephthalate (PET) to improve its adhesion with energetic polymer. The PET surface pre- and post-plasma treatment was characterized by X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM), and the enhancement mechanism of the interface adhesion was discussed. In addition, the ablation performance of the double-layer tape after the plasma treatment was studied. The results showed that the plasma etching effect increased the root mean square roughness of the PET surface from 1.74 nm to 19.10 nm. In addition, after the plasma treatment, the number of C–OH/COOH bonds and O=C–O bonds increased, which also greatly improved the adhesion between the PET and energetic polymers. In the optimization of the ablation performance, the optimal laser pulse width was about 200 μs. The optimal values of the specific impulse (Isp), impulse coupling coefficient (Cm), and ablation efficiency (η) were 390.65 s, 250.82 μN/W, and 48.01%, respectively. The optimization of the adhesion of the double-layer tape and the ablation performance lay the foundation for the engineering application of laser ablation micro-thrusters.
Cellulose Nanocrystals (CNC)-Based Functional Materials for Supercapacitor Applications
Authors: Durairaj Arulppan , Maruthapandi Moorthy , Saravanan Arumugam , Luong John H. T. , Gedanken Aharon
Published: May 2022

The growth of industrialization and the population has increased the usage of fossil fuels, resulting in the emission of large amounts of CO2. This serious environmental issue can be abated by using sustainable and environmentally friendly materials with promising novel and superior performance as an alternative to petroleum-based plastics. Emerging nanomaterials derived from abundant natural resources have received considerable attention as candidates to replace petroleum-based synthetic polymers. As renewable materials from biomass, cellulose nanocrystals (CNCs) nanomaterials exhibit unique physicochemical properties, low cost, biocompatibility and biodegradability. Among a plethora of applications, CNCs have become proven nanomaterials for energy applications encompassing energy storage devices and supercapacitors. This review highlights the recent research contribution on novel CNC-conductive materials and CNCs-based nanocomposites, focusing on their synthesis, surface functionalization and potential applications as supercapacitors (SCs). The synthesis of CNCs encompasses various pretreatment steps including acid hydrolysis, mechanical exfoliation and enzymatic and combination processes from renewable carbon sources. For the widespread applications of CNCs, their derivatives such as carboxylated CNCs, aldehyde-CNCs, hydride-CNCs and sulfonated CNC-based materials are more pertinent. The potential applications of CNCs-conductive hybrid composites as SCs, critical technical issues and the future feasibility of this endeavor are highlighted. Discussion is also extended to the transformation of renewable and low-attractive CNCs to conductive nanocomposites using green approaches. This review also addresses the key scientific achievements and industrial uses of nanoscale materials and composites for energy conversion and storage applications.
Advances in Electrospun Hybrid Nanofibers for Biomedical Applications
Authors: Nirwan Viraj P. , Kowalczyk Tomasz , Bar Julia , Buzgo Matej , Filová Eva , Fahmi Amir
Published: May 2022

Electrospun hybrid nanofibers, based on functional agents immobilized in polymeric matrix, possess a unique combination of collective properties. These are beneficial for a wide range of applications, which include theranostics, filtration, catalysis, and tissue engineering, among others. The combination of functional agents in a nanofiber matrix offer accessibility to multifunctional nanocompartments with significantly improved mechanical, electrical, and chemical properties, along with better biocompatibility and biodegradability. This review summarizes recent work performed for the fabrication, characterization, and optimization of different hybrid nanofibers containing varieties of functional agents, such as laser ablated inorganic nanoparticles (NPs), which include, for instance, gold nanoparticles (Au NPs) and titanium nitride nanoparticles (TiNPs), perovskites, drugs, growth factors, and smart, inorganic polymers. Biocompatible and biodegradable polymers such as chitosan, cellulose, and polycaprolactone are very promising macromolecules as a nanofiber matrix for immobilizing such functional agents. The assimilation of such polymeric matrices with functional agents that possess wide varieties of characteristics require a modified approach towards electrospinning techniques such as coelectrospinning and template spinning. Additional focus within this review is devoted to the state of the art for the implementations of these approaches as viable options for the achievement of multifunctional hybrid nanofibers. Finally, recent advances and challenges, in particular, mass fabrication and prospects of hybrid nanofibers for tissue engineering and biomedical applications have been summarized.
The Adsorption of Heavy Metal Ions by Poly (Amidoamine) Dendrimer-Functionalized Nanomaterials: A Review
Authors: Guo Dandan , Huang Shaohua , Zhu Yan
Published: May 2022

Rapid industrialization has resulted in serious heavy metal pollution. The removal of heavy metal ions from solutions is very important for environmental safety and human health. Poly (amidoamine) (PAMAM) dendrimers are artificial macromolecular materials with unique physical and chemical properties. Abundant amide bonds and amino functional groups provide them with a high affinity for heavy metal ions. Herein, PAMAM-functionalized adsorbents are reviewed in terms of different nanomaterial substrates. Approaches in which PAMAM is grafted onto the surfaces of substrates are described in detail. The adsorption isotherms and kinetics of these adsorbents are also discussed. The effects of PAMAM generation, pH, adsorbent dosage, adsorption time, thermodynamics, and ionic strength on adsorption performance are summarized. Adsorption mechanisms and the further functionalization of PAMAM-grafted adsorbents are reviewed. In addition to the positive results, existing problems are also put forward in order to provide a reference for the optimization of PAMAM-grafted adsorbents of heavy metal ions.
Simulation of a High-Performance Polarization Beam Splitter Assisted by Two-Dimensional Metamaterials
Authors: Chang Ruei-Jan , Huang Chia-Chien
Published: May 2022

It is challenging to simultaneously consider device dimension, polarization extinction ratio (PER), insertion loss (IL), and operable bandwidth (BW) to design a polarization beam splitter (PBS) that is extensively used in photonic integrated circuits. The function of a PBS is to separate polarizations of light, doubling the transmission bandwidth in optical communication systems. In this work, we report a high-performance PBS comprising two-dimensional subwavelength grating metamaterials (2D SWGMs) between slot waveguides. The 2D SWGMs exhibited biaxial permittivity by tailoring the material anisotropy. The proposed PBS showed PERs of 26.8 and 26.4 dB for TE and TM modes, respectively, and ILs of ~0.25 dB for both modes, with an unprecedented small footprint of 1.35 μm × 2.75 μm working at the wavelength λ = 1550 nm. Moreover, the present structure attained satisfactory PERs of >20 dB and ILs of <0.5 dB within an ultrabroad BW of 200 nm.
Polarization Sensitive Photodetectors Based on Two-Dimensional WSe2
Authors: Guskov Andrey , Lavrov Sergey , Galiev Rinat
Published: May 2022

In this work we show the possibility of imparting polarization-sensitive properties to two-dimensional films of graphene-like semiconductors, using WSe2 as an example, by the application of ordered silver triangular nanoprisms. In addition, such nanoprisms made it possible to increase the optical sensitivity of optical detectors created on two-dimensional films by a factor of five due to surface plasmon resonance. The peculiarities of the surface plasmon resonance were shown by theoretical modeling, and the optimal conditions of its occurrence were determined. This article demonstrates an effective approach to creating spectrally selective, polarization-sensitive detectors based on two-dimensional graphene-like semiconductors.
The Functional Roles and Regulation of Circular RNAs during Cellular Stresses
Authors: Lee Yueh-Chun , Wang Wei-Yu , Lin Hui-Hsuan , Huang Yi-Ren , Lin Ya-Chi , Hsiao Kuei-Yang
Published: May 2022

Circular RNAs (circRNAs) are a novel class of regulatory RNA involved in many biological, physiological and pathological processes by functioning as a molecular sponge, transcriptional/epigenetic/splicing regulator, modulator of protein–protein interactions, and a template for encoding proteins. Cells are constantly dealing with stimuli from the microenvironment, and proper responses rely on both the precise control of gene expression networks and protein–protein interactions at the molecular level. The critical roles of circRNAs in the regulation of these processes have been heavily studied in the past decades. However, how the microenvironmental stimulation controls the circRNA biogenesis, cellular shuttling, translation efficiency and degradation globally and/or individually remains largely uncharacterized. In this review, how the impact of major microenvironmental stresses on the known transcription factors, splicing modulators and epitranscriptomic regulators, and thereby how they may contribute to the regulation of circRNAs, is discussed. These lines of evidence will provide new insight into how the biogenesis and functions of circRNA can be precisely controlled and targeted for treating human diseases.
Hyperuricemia and Its Association with Osteoporosis in a Large Asian Cohort
Authors: Li Jhong-You , Lee Jia-In , Lu Cheng-Chang , Su Yu-De , Chiu Chao-Tse , Chen Szu-Chia , Geng Jiun-Hung , Chen Chung-Hwan
Published: May 2022

In this paper, we aimed to examine the protective role of hyperuricemia in the prevalence of osteoporosis in a large Asian cohort. A total of 119,037 participants from 29 recruitment centers in Taiwan were enrolled onto our study. Participants with serum uric acid greater than 7.0 mg/dL in men and 6.0 mg/dL in women were classified as the hyperuricemia group whereas the others were the control group. The mean age of all participants was 50; there were 23,114 subjects (19%) with hyperuricemia. Osteoporosis was observed in 8243 (9%) and 1871 (8%) participants in the control and hyperuricemia groups, respectively. After adjusting for confounders, a lower risk of osteoporosis was found in the hyperuricemia group compared with the control group (odds ratio, 0.916; 95% confidence interval, 0.864 to 0.970). A subgroup analysis showed that hyperuricemia was associated with a lower risk of osteoporosis in females, but not in males. Women with serum uric acid greater than 8.0 mg/dL were not associated with a greater risk of osteoporosis. Our study suggests that hyperuricemia decreases the risk of osteoporosis in females, but not in males. The protective role was no longer apparent when the serum uric acid level was greater than 8 mg/dL.
The Storage Conditions of High-Fat Diet Are the Key Factors for Diet-Induced Obesity and Liver Damage
Authors: Yi Chuanyou , Li Dandan , Guo Xiao , Wang Jinhui , Liu Cenxi , Lu Guangxing , Sun Yan , Huang He , Hong Shangyu , Li Jin
Published: May 2022

The diet-induced obesity (DIO) mouse model has been widely used for obesity studies. The effects of storage conditions on the composition of nutrients in high-fat diets (HFDs) and their impact on metabolic homeostasis have not been systemically investigated. In the current study, we tested the effects of HFDs stored under different conditions and found that mice fed a HFD stored in the fridge (HFDfri) gained less weight than those fed HFDs stored in the freezer (HFDfre). Further analysis revealed that changes in the relative abundance of medium-chain triglyceride (MCT) in the HFDfri, which have much lower intestinal absorption rates, contributed to the body weight differences. In contrast, exacerbated liver damage and elevated levels of unfolded protein response (UPR) was observed in the mice fed by HFDfri. Depletion of the UPR-regulated gene Nnmt alleviated liver damage via the inhibition of the integrated stress response (ISR). Our study, for the first time, provides evidence that HFD storage conditions can have a significant impact on both body weight changes and liver damage in the DIO model.
Effect of Dietary and Lifestyle Interventions on the Amelioration of NAFLD in Patients with Metabolic Syndrome: The FLIPAN Study
Authors: Montemayor Sofía , Bouzas Cristina , Mascaró Catalina M. , Casares Miguel , Llompart Isabel , Abete Itziar , Angullo-Martinez Escarlata , Zulet María Ángeles , Martínez J. Alfredo , Tur Josep A.
Published: May 2022

Background: Adults with fatty liver present unusual glycaemia and lipid metabolism; as a result, non-alcoholic fatty liver disease (NAFLD) is now considered as part of the metabolic syndrome (MetS). Objective: To assess the 6- and 12-month effects of customized hypocaloric dietary and enhanced physical activity intervention on intrahepatic fat contents and progression of NAFLD, in patients with MetS. Design: Cross-sectional study in 155 participants (40–60 years old) from Balearic Islands and Navarra (Spain) with a diagnosis of NAFLD and MetS, and BMI (body mass index) between 27 and 40 kg/m2; patients were randomized in a 1:1:1 ratio to either Conventional Diet, Mediterranean diet (MD)–high meal frequency, and MD–physical activity groups. Methods: Dietary intake was assessed using a validated food frequency questionnaire. Adherence to Mediterranean diet, anthropometrics, physical activity, and biochemical parameters (fasting glucose, glycated hemoglobin, bilirubin, aspartate aminotransferase, alanine aminotransferase—ALT–, gamma-glutamyl transferase, uric acid, urea, creatinine, albumin, total cholesterol, high-density lipoprotein cholesterol—HDL-cholesterol–, and triglycerides) were also assessed. Results: Subjects with NAFLD and MetS had reduced intrahepatic fat contents, and liver stiffness, despite the intervention the participants went through. All participants ameliorated BMI, insulin, Hb1Ac, diastolic blood pressure, HDL-cholesterol, and ALT, and improved consumption of total energy, fish, and legumes. Participants in the MD–HMF group improved waist circumference. Conclusions: Customized hypocaloric dietary and enhanced physical activity interventions may be useful to ameliorate NAFLD.
Media Pressures, Internalization of Appearance Ideals and Disordered Eating among Adolescent Girls and Boys: Testing the Moderating Role of Body Appreciation
Authors: Jankauskiene Rasa , Baceviciene Migle
Published: May 2022

The aim of the present study was to test the moderating role of body appreciation in the mediation model of media pressures, internalization of appearance ideals, and disordered eating in adolescents. One thousand four hundred and twelve Lithuanian adolescents (40.4% were boys, age range: 15–18 years) participated in the cross-sectional study. The mean age of the sample was 16.9 (SD (standard deviation) = 0.5) for girls and 17.0 (SD = 0.4) for boys. Adolescents completed a questionnaire consisting of measures of body appreciation (Body Appreciation Scale-2 (BAS-2)), disordered eating (Eating Disorder Examination Questionnaire 6 (EDE-Q 6)), attitudes towards sociocultural pressures towards appearance (Sociocultural Attitudes towards Appearance Questionnaire 4 (SATAQ-4)), and time browsing internet for leisure purposes. To assess the primary hypotheses, moderated mediation models were tested separately in boys and girls. In girls, body appreciation moderated associations between media pressures and internalization of thin body ideals and between internalization of thin appearance ideals and disordered eating. In boys, body appreciation moderated only the association between media pressures and disordered eating. The effect of media pressures on disordered eating was the highest in boys with the lowest body appreciation. Body appreciation protects adolescent girls from internalization of thin appearance ideals in the presence of media pressures and from disordered eating in the case of internalization of thin body appearance ideals. In boys, body appreciation provides a protective effect from media pressures towards appearance to disordered eating behaviors. The findings of the present study could inform intervention programs that aim to prevent disordered eating, strengthen positive body image, and promote healthy eating in adolescent girls and boys. Specific programs might be beneficial in preventing disordered eating in boys with low body appreciation.
The Influence of Obesity on Nutrition and Physical Activity during COVID-19 Pandemic: A Case-Control Study
Authors: Wyleżoł Mariusz , Sińska Beata I. , Kucharska Alicja , Panczyk Mariusz , Raciborski Filip , Szostak-Węgierek Dorota , Milewska Magdalena , Samoliński Bolesław , Frączek Mariusz , Traczyk Iwona
Published: May 2022

Obesity is one of the important risk factors for a severe course of COVID-19. Maintaining a healthy body weight through diet and physical activity is a reasonable approach to preventing a SARS-CoV-2 infection or in alleviating its course. The goal of the study was to determine the influence of obesity on nutrition and physical activity during the COVID-19 pandemic. A total of 964 respondents, including 227 individuals with a body mass index (BMI) ≥30 kg/m2 were evaluated in this study. In the case of 482 respondents, including 105 individuals (21.8%) with BMI ≥ 30 kg/m2, the data were collected during the pandemic period from 1 June to 31 August 2020. The remaining 482 individuals were the “pre-pandemic” group, selected via propensity score matching (PSM) out of the 723 National Health Program study participants whose data was collected in 2017–2019. The evaluated dietary health factors were quantitatively similar in patients with BMI of either <30 kg/m2 or ≥30 kg/m2 and showed no significant changes during the pandemic. The diets of those who suffered from obesity prior to the pandemic showed the evaluated unhealthy nutritional factors to be less pronounced in comparison with those of individuals with BMI < 30 kg/m2. During the pandemic, the BMI ≥ 30 kg/m2 group showed a significant increase in the overall calorie intake (by 319 kcal; p = 0.001) and an increased consumption of total carbohydrates 299.3 ± 83.8 vs. 252.0 ± 101.5; p = 0.000), sucrose (51.7 ± 30.0 vs. 71.6 ± 49.9; p = 0.000), plant protein (26.3 ± 12.1 vs. 29.3 ± 8.3; p = 0.040), total fat (73.1 ± 42.6 vs. 84.9 ± 29.6; p = 0.011) and saturated fatty acids (29.5 ± 16.4 vs. 34.3 ± 13.9; p = 0.014) in comparison with the pre-pandemic period. The energy and nutritional value of the diets of BMI < 30 kg/m2 individuals did not change between the pre-pandemic and pandemic period. Before the pandemic, the level of leisure physical activity of the BMI ≥ 30 kg/m2 group was significantly lower than of those with BMI < 30 kg/m2. Such differences were not observed in the levels of physical activity at work or school. The pandemic did not alter the amount of physical activity either during leisure time or at work/school in individuals with BMI ≥ 30 kg/m2. However, respondents without obesity exercised significantly less during the pandemic than before. In conclusion, the pandemic altered the diets and levels of physical activity in the Polish population, with dietary changes observed in individuals with BMI ≥ 30 kg/m2 and changes in physical activity observed in those with BMI < 30 kg/m2.
Metabolomic Profile of Different Dietary Patterns and Their Association with Frailty Index in Community-Dwelling Older Men and Women
Authors: Tanaka Toshiko , Talegawkar Sameera A. , Jin Yichen , Candia Julián , Tian Qu , Moaddel Ruin , Simonsick Eleanor M. , Ferrucci Luigi
Published: May 2022

Diet quality has been associated with slower rates of aging; however, the mechanisms underlying the role of a healthy diet in aging are not fully understood. To address this question, we aimed to identify plasma metabolomic biomarkers of dietary patterns and explored whether these metabolites mediate the relationship between diet and healthy aging, as assessed by the frailty index (FI) in 806 participants of the Baltimore Longitudinal Study of Aging. Adherence to different dietary patterns was evaluated using the Mediterranean diet score (MDS), Mediterranean–DASH Diet Intervention for Neurodegenerative Delay (MIND) score, and Alternate Healthy Eating Index-2010 (AHEI). Associations between diet, FI, and metabolites were assessed using linear regression models. Higher adherence to these dietary patterns was associated with lower FI. We found 236, 218, and 278 metabolites associated with the MDS, MIND, and AHEI, respectively, with 127 common metabolites, which included lipids, tri/di-glycerides, lyso/phosphatidylcholine, amino acids, bile acids, ceramides, cholesterol esters, fatty acids and acylcarnitines, indoles, and sphingomyelins. Metabolomic signatures of diet explained 28%, 37%, and 38% of the variance of the MDS, MIND, and AHEI, respectively. Signatures of MIND and AHEI mediated 55% and 61% of the association between each dietary pattern with FI, while the mediating effect of MDS signature was not statistically significant. The high number of metabolites associated with the different dietary patterns supports the notion of common mechanisms that underly the relationship between diet and frailty. The identification of multiple metabolite classes suggests that the effect of diet is complex and not mediated by any specific biomarkers. Furthermore, these metabolites may serve as biomarkers for poor diet quality to identify individuals for targeted dietary interventions.