bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Lipoprotein Ratios and Remnant Cholesterol in Patients with Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA)
Authors: Sucato Vincenzo , Di Fazio Luca , Madaudo Cristina , Vadalà Giuseppe , D’Agostino Alessandro , Evola Salvatore , Novo Giuseppina , Corrado Egle , Galassi Alfredo Ruggero
Published: May 2024

Background: Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a clinical situation characterized by evidence of acute myocardial infarction (AMI)—according to the Fourth Universal Definition of Myocardial Infarction—with normal or near-normal coronary arteries on angiographic study (stenosis < 50%). This condition is extremely variable in etiology, pathogenic mechanisms, clinical manifestations, prognosis and consequently therapeutic approach. Objective: The objective of the study was the evaluation of remnant cholesterol (RC), monocyte/high-density lipoprotein cholesterol ratio (MHR), platelet/lymphocyte ratio (PLR) and various lipoprotein ratios in patients with MINOCA in order to establish their validity as predictors of this event. Materials and Methods: We included 114 patients hospitalized in the Intensive Coronary Care Unit (ICCU) and Hospital Wards of our Hospital Center from 2015 to 2019 who received a diagnosis of MINOCA compared to a control group of 110 patients without previous cardiovascular events. RC was calculated with the following formula: RC = total cholesterol (TC) − HDL-C − LDL-C. MHR was calculated by dividing the monocyte count in peripheral blood by high-density lipoprotein cholesterol (HDL-C) levels; PLR was obtained by dividing platelet count by lymphocyte count. We also calculated various lipoprotein ratios, like total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C), low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL-C/HDL-C), triglycerides/high-density lipoprotein cholesterol (TG/HDL-C), and non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol (non-HDL-C/HDL-C) ratios. Results: The MINOCA group had higher mean levels of RC (21.3 ± 10.6 vs. 13.2 ± 7.7 mg/dL), MHR (23 ± 0.009 vs. 18.5± 8.3) and PLR (179.8 ± 246.1 vs. 135 ± 64.7) than the control group. Only the mean values of all calculated lipoprotein ratios were lower in MINOCA patients. Statistical significance was achieved only in the RC evaluation. Conclusions: Higher levels of RC and MHR were found in patients with MINOCA. We also observed higher levels of PLR than in the control group. Only various lipoprotein ratios were lower, but this could reflect the extreme heterogeneity underlying the pathogenic mechanisms of MINOCA. In patients who receive a diagnosis of MINOCA with a baseline alteration of the lipid profile and higher levels of cholesterol at admission as well, the evaluation of these parameters could play an important role, providing more detailed information about their cardiometabolic risk.
Comparative Analysis of Response to Cardiac Resynchronisation Therapy Upgrades in Patients with Implantable Cardioverter-Defibrillators and Pacemakers
Authors: Farhangee Arsalan , Davies Mark J. , Mesina Mihai , Morgan David Roger , Sieniewicz Benjamin J. , Meyrick Robyn , Gaughan Katie , Mîndrilă Ion
Published: May 2024

Introduction: The efficacy of de novo cardiac resynchronisation therapy (CRT) in patients with heart failure (HF), left ventricular systolic dysfunction (LVSD), and a broad QRS morphology is well established. However, the optimal stage for upgrading patients with existing pacemakers (PPMs) or implantable cardioverter-defibrillators (ICDs) and HF with high-burden right ventricular (RV) pacing remains uncertain. Thus, this multicentre retrospective analysis compared patients with pre-existing PPMs or ICDs who underwent CRT upgrades to investigate the appropriate stage for CRT implantation in these patients and to assess the validity of treating both PPM and ICD recipients under the same recommendation level in the current guidelines. Materials and Methods: A total of 151 participants underwent analysis in this study, comprising 93 upgrades to cardiac resynchronisation therapy with pacemaker (CRT-P) and 58 upgrades to cardiac resynchronisation therapy with defibrillator (CRT-D) across three centres in the UK. The aim of the study was to investigate the safety and efficacy of upgrading to CRT from an existing conventional pacemaker or an ICD in the context of high-burden RV pacing. The analysis was conducted separately for each group, assessing changes in echocardiographic parameters, functional New York Heart Association (NYHA) class, and procedure-related complications. Results: The PPM group had a higher percentage RVP burden compared to the ICD group. Post-upgrade, NYHA functional class and EF and LV volumes improved in both groups; however, the response to an upgrade from a pacemaker was greater compared to an upgrade from an ICD. Post-procedural complication risks were similar across the two subgroups but significantly higher compared to de novo implantation. Conclusions: Within the CRT-P subgroup, participants exhibited better responses than their CRT-D counterparts, evident both in echocardiographic improvements and clinical outcomes. Furthermore, patients with non-ischemic cardiomyopathy (NICM) were better responders than those with ischaemic cardiomyopathy. These findings suggest that international guidelines should consider approaching each subgroup separately in the future.
Cenobamate Plasma Levels in Patients with Epilepsy: Correlation with Efficacy and Tolerability?
Authors: Steinhoff Bernhard J. , Georgiou Dimitra , Dietmann Daniel , Intravooth Tassanai
Published: May 2024

Objective: Cenobamate is approved by the European Medicine Agency for the treatment of adult patients with epilepsy (PWEs) with ongoing focal-onset seizures despite appropriate treatment with at least two established antiseizure medications. Pivotal trials and post-marketing real-world observational studies suggest high efficacy with unusually high seizure-free rates. The authors sought to investigate the plasma levels of cenobamate under steady-state conditions in seizure-free versus non-responding PWEs, and in PWEs who experienced adverse events versus those who did not. Methods: Blood samples were collected from adult PWEs who were treated with adjunct cenobamate under steady-state conditions. Daily doses, concomitant medications, efficacy, and tolerability were assessed. The plasma cenobamate levels of seizure-free versus non-responding PWEs and between PWEs with and those without clinical adverse events were compared. Results: Samples from 101 PWEs were included. Thirty-six PWEs were seizure-free and 65 were non-responders. In 31 PWEs, adverse events were apparent, whereas in the remaining 70, no tolerability issues were reported. A linear correlation was found between the daily doses (range: 100 mg–400 mg) and the plasma levels (3.8 mg/L–54.6 mg/L). Neither the daily doses nor the plasma levels differed significantly between the investigated subgroups. The main reason for this result was that the individual therapeutic ranges varied widely: seizure freedom and adverse effects were observed alongside low doses and plasma levels in some PWEs. Conversely, there were examples of PWEs who did not respond or who reported no tolerability issues at high doses or plasma levels. Conclusions: To evaluate the individual therapeutic range and to better understand the influence of other drugs in cases where concomitant medications are used, the therapeutic drug monitoring of cenobamate may be useful. A general therapeutic range cannot be defined.
A Prospective Randomized Controlled Clinical Study to Investigate the Efficacy and Safety of Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitors in Non-Dialysis Patients with Chronic Heart Failure and Renal Anemia Switched from Continuous Erythropoietin Receptor Activator Treatment
Authors: Sezai Akira , Abe Masanori , Maruyama Takashi , Taoka Makoto , Sekino Hisakuni , Tanaka Masashi
Published: May 2024

Background/Objectives: Chronic kidney disease (CKD) and anemia are independent prognostic factors for heart failure. In recent years, hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitors have become available for the treatment of renal anemia. This prospective randomized controlled study aimed to investigate the effects of switching from a continuous erythropoietin receptor activator (CERA) to one of four HIF-PH inhibitors in patients with chronic heart failure and renal anemia. Methods: Forty patients were randomized by the envelop method to receive treatment with roxadustat, daprodustat, vadadustat, or molidustat. The primary endpoint was the change in the hemoglobin (Hb) level. Secondary endpoints included changes in erythropoietin, changes in free T3, free T4, and thyroid-stimulating hormone (TSH), adverse effects, and drug dose increases and decreases. This study was preregistered in the University Hospital Medical Information Network Clinical Trials Registry (study ID: UMIN000041651). Results: We found no statistically significant difference between Hb levels with HIF-PH inhibitors and CERA, but at month 6, the Hb level was significantly higher with roxadustat than with vadadustat and daprodustat. Erythropoietin decreased significantly after switching to HIF-PH inhibitors. HIF-PH inhibitors had various significant effects on free T3, free T4, and TSH. No adverse events occurred. The doses of some drugs had to be increased or decreased. Conclusions: In patients with heart failure and renal anemia receiving CERA, Hb, NT-ProBNP, and renal function were similar after switching from CERA to HIF-PH inhibitors. The individual HIF-PH inhibitors appear to have different effects on anemia and thyroid function. However, because this was a single-center study with a limited sample size, the efficacy and potential limitations of HIF-PH inhibitors need to be further clarified.
Multi-Modal Prehabilitation in Thoracic Surgery: From Basic Concepts to Practical Modalities
Authors: Licker Marc , El Manser Diae , Bonnardel Eline , Massias Sylvain , Soualhi Islem Mohamed , Saint-Leger Charlotte , Koeltz Adrien
Published: May 2024

Over the last two decades, the invasiveness of thoracic surgery has decreased along with technological advances and better diagnostic tools, whereas the patient’s comorbidities and frailty patterns have increased, as well as the number of early cancer stages that could benefit from curative resection. Poor aerobic fitness, nutritional defects, sarcopenia and “toxic” behaviors such as sedentary behavior, smoking and alcohol consumption are modifiable risk factors for major postoperative complications. The process of enhancing patients’ physiological reserve in anticipation for surgery is referred to as prehabilitation. Components of prehabilitation programs include optimization of medical treatment, prescription of structured exercise program, correction of nutritional deficits and patient’s education to adopt healthier behaviors. All patients may benefit from prehabilitation, which is part of the enhanced recovery after surgery (ERAS) programs. Faster functional recovery is expected in low-risk patients, whereas better clinical outcome and shorter hospital stay have been demonstrated in higher risk and physically unfit patients.
Retrograde Peroneal Artery Approach to Treat Infra-Inguinal Arterial Chronic Total Occlusions: A Multicentre Experience and Technical Considerations
Authors: Patrone Lorenzo , Falcone Gianmarco , Coscas Raphael , Lichaa Hady , Antaredja Muliadi , Fanelli Fabrizio , Blessing Erwin
Published: May 2024

Background/Objectives: Retrograde access of the peroneal artery (PA) is considered technically challenging and at risk of bleeding. The aim of this multicentre retrospective study was to assess the safety, feasibility, and technical success of this access route for infrainguinal endovascular recanalizations. Methods: We retrospectively analyzed 186 consecutive patients treated over a 7-year period (May 2014–August 2021) who underwent endovascular recanalization of infra-inguinal lesions using a PA access route. In all cases, retrograde PA access was obtained following a failed attempt to cross the occlusion via the antegrade route. Results: Among the 186 patients, 120 were males (60.5%) and the mean age was 76.8 ± 10.7 years old (44–94 years). One hundred and thirteen patients (60.7%) suffered from chronic limb threatening ischemia (CLTI). All patients presented with chronic total occlusions (CTO) and a failed conventional antegrade recanalization attempt. Retrograde access was performed under angiographic guidance in 185 cases (99.5%). It was successfully established in 171 cases (91.9%). The total rate of retrograde puncture-related complications was 2.1% (two puncture site bleedings of which one necessitated fasciotomy and two cases of arteriovenous fistulas managed conservatively). The Major Adverse Event (MAE) rate at 30 days was 1.6% (3/186). Conclusions: Retrograde recanalization of challenging infra-inguinal lesions via PA is safe and effective in experienced hands.
Alexithymia Increases Pericranial and Cervical Muscle Tenderness in Women with Migraine
Authors: Rota Eugenia , Cavagnetto Elisa , Immovilli Paolo , Frola Enrico , Salari Pavel , Morelli Nicola , Battaggia Alessandro
Published: May 2024

Background/Objectives: Alexithymia is characterized by a deficit in identifying and communicating feelings. Emerging evidence suggests that alexithymia is highly prevalent in migraine, in a complex interplay with psychiatric comorbidity. Pericranial/cervical muscle tenderness is a remarkable clinical feature in a large proportion of migraine patients. This pilot study aimed at investigating the relationship between alexithymia and pericranial/cervical muscle tenderness in female migraineurs. Methods: A total of 42 female patients fulfilling the diagnostic criteria for migraine were enrolled into this pilot, observational, cross-sectional study after informed consent was obtained. Each patient underwent a psychological assessment to identify any alexithymia by means of TAS-20, anxiety/mood comorbidity (by means of STAI-Y1 STAI-Y2, BDI-II), and migraine-related disability (by means of HIT-6), and a physical cranial/cervical musculoskeletal examination. Palpation of pericranial and cervical muscles was carried out in the standardized manner. A Cumulative Muscle Tenderness (CUM) score (0–6) was calculated for each patient. A multivariate analysis was performed to investigate any association amongst the TAS-20 score, the CUM score, and the following covariates: BDI-II, STAI-Y1, STAI-Y2, and HIT-6 scores, age, disease duration, monthly migraine days, and average head pain intensity in the previous three months. Results: Overall, 35.6% of the sample had alexithymia. The multivariate analysis detected a linear and independent relationship between the TAS-20 and CUM scores, with a statistically significant (p = 0.017) association. Conclusions: This pilot study suggests that alexithymia plays a role in increasing pericranial/cervical muscle tenderness in migraine, independently from psychiatric comorbidity. A novel therapeutical approach, targeting alexithymia, may well reduce muscular tenderness in female migraineurs.
Predictors of Metastasis in 68GA-Prostate Specific Membrane Antigen Pet-CT in the Primary Staging of Prostate Cancer
Authors: Karaca Erkin , Kisa Erdem , Cakici Mehmet Caglar , Cetin Taha , Yalcin Mehmet Yigit , Ozbilen Mert Hamza , Bildirici Cagdas , Koc Gokhan
Published: May 2024

Background: The objective of this study was to investigate factors influencing Gallium 68 Prostate Specific Membrane Antigen Positron Emission Tomography (Ga68 PSMA PET-CT) uptake for primary staging in prostate cancer. Methods: Retrospective analysis was conducted on 499 non-metastatic and 243 de novo metastatic prostate cancer cases undergoing Ga68 PSMA PET-CT. Demographic, clinical, and imaging data were collected and analyzed. Multivariate logistic regression determined independent risk factors for metastasis detection on Ga68 PSMA PET-CT. Results: Metastatic cases showed higher levels of total PSA, PSA density (dPSA) and biopsy ISUP grade group compared to non-metastatic cases. Multivariate analysis identified cT2 stage and dPSA as independent predictors of metastasis detection on Ga68 PSMA PET-CT. Conclusions: Ga68 PSMA PET-CT plays a crucial role in prostate cancer staging, with identified factors such as clinical T stage and dPSA significantly impacting its diagnostic accuracy. These findings underscore the importance of Ga68 PSMA PET-CT in refining clinical staging and guiding treatment decisions for prostate cancer patients.
Review of Image Quality Assessment Methods for Compressed Images
Authors: Jamil Sonain
Published: May 2024

The compression of images for efficient storage and transmission is crucial in handling large data volumes. Lossy image compression reduces storage needs but introduces perceptible distortions affected by content, compression levels, and display environments. Each compression method generates specific visual anomalies like blocking, blurring, or color shifts. Standardizing efficient lossy compression necessitates evaluating perceptual quality. Objective measurements offer speed and cost efficiency, while subjective assessments, despite their cost and time implications, remain the gold standard. This paper delves into essential research queries to achieve visually lossless images. The paper describes the influence of compression on image quality, appropriate objective image quality metrics (IQMs), and the effectiveness of subjective assessment methods. It also provides an overview of the existing literature, surveys, and subjective and objective image quality assessment (IQA) methods. Our aim is to offer insights, identify challenges in existing methodologies, and assist researchers in selecting the most effective assessment approach for their needs.
Folate-Mediated One-Carbon Metabolism in the Crustacean Copepod Calanus finmarchicus: Identification of Transcripts and Relative Expression across Development
Authors: Ascione Daniela , Carotenuto Ylenia , Lauritano Chiara , Roncalli Vittoria
Published: May 2024

Folate, also known as vitamin B9, plays a crucial role in the one-carbon (1C) metabolism, a conserved pathway from microbes to humans. The 1C metabolism, consisting of the folate and methionine cycles, is essential in many biological processes such as nucleotide and protein biosynthesis, cell proliferation, and embryonic development. Despite its functional role, little is known about the 1C metabolism in crustaceans. As part of an ongoing effort to characterize important pathways in Calanus finmarchicus, the biomass-dominant zooplankton in much of the North Atlantic Ocean, we identified transcripts encoding the 1C metabolism enzymes. Using an in silico workflow consisting of a transcriptome mining, reciprocal blasts, and structural analyses of the deduced proteins, we identified the entire set of enzymes in both cycles. The majority encoded for full-length proteins and clustered with homologs from other species. Stage-specific expression was reported, with several transcripts showing high expression in the naupliar stage (e.g., 10-FTHFD, SHMT2) while some methyltransferases (e.g., BHMT, SHMT, DNMT) were more expressed in adults. Overall, this study provides a set of genes which can be used as potential biomarkers of development and reproduction and can be tested in other zooplankters to assess ocean health status monitoring.
Response of Shallow-Water Temperature and Significant Wave Height to Sequential Tropical Cyclones in the Northeast Beibu Gulf
Authors: Chen Xiaotong , Xie Lingling , Li Mingming , Xu Ying , Wang Yulin
Published: May 2024

Using shallow-water buoy observations, reanalysis data, and numerical models, this study analyzes the variations in sea temperature and significant wave height (SWH) caused by two sequential tropical cyclones (TCs) ‘Lionrock’ and ‘Kompasu’ in October 2021 in the northeast Beibu Gulf, South China Sea. The results show that the sea surface temperature (SST) cooling of the nearshore waters was larger than the offshore water in the basin of the gulf, with the cooling amplitude and rate decreasing and the cooling time lagging behind wind increasing from coast to offshore. The near-surface temperature at the buoy station had a maximum decrease of 2.8 °C after ‘Lionrock’, and the decrease increased slightly to 3 °C after the stronger wind of ‘Kompasu’. The total decrease of 4.6 °C indicates that the sequential TCs had a superimposed effect on the cooling of the Beibu Gulf. The heat budget analysis revealed that the sea surface heat loss and the Ekman pumping rate in the nearshore waters during ‘Kompasu’ (−535 W/m2 and 5.8 × 10−4 m/s, respectively) were significantly higher than that (−418 W/m2 and 4 × 10−4 m/s) during ‘Lionrock’. On the other hand, the SST cooling (−1.2 °C) during the second TC is smaller than (−1.6 °C) the first weaker TC in the gulf basin, probably due to the deepening of the mixed layer. During the observation period, the waves in the Beibu Gulf were predominantly wind-driven. The maximum SWHs reached 1.58 m and 2.3 m at the bouy station near shore during the two TCs, and the SWH variation was highly correlated to the wind variation with a correlation of 0.95. The SWH increases from the nearshore to offshore waters during the TCs. The SAWN and ARCIRC coupled model results suggest that wave variations in the Beibu Gulf are primarily influenced by water depth, bottom friction, and whitecapping. Two days after the TCs, sea surface cooling and high waves appeared again due to a cold air event.
Central Carbon Metabolism in Candida albicans Biofilms Is Altered by Dimethyl Sulfoxide
Authors: Arruda Maria Fernanda Cordeiro , da Silva Ramos Romeu Cassiano Pucci , de Oliveira Nicoly Subtil , Rosa Rosimeire Takaki , Stuelp-Campelo Patrícia Maria , Bianchini Luiz Fernando , Villas-Bôas Silas Granato , Rosa Edvaldo Antonio Ribeiro
Published: May 2024

The effect of dimethyl sulfoxide (DMSO) on fungal metabolism has not been well studied. This study aimed to evaluate, by metabolomics, the impact of DMSO on the central carbon metabolism of Candida albicans. Biofilms of C. albicans SC5314 were grown on paper discs, using minimum mineral (MM) medium, in a dynamic continuous flow system. The two experimental conditions were control and 0.03% DMSO (v/v). After 72 h of incubation (37 °C), the biofilms were collected and the metabolites were extracted. The extracted metabolites were subjected to gas chromatography–mass spectrometry (GC/MS). The experiment was conducted using five replicates on three independent occasions. The GC/MS analysis identified 88 compounds. Among the 88 compounds, the levels of 27 compounds were markedly different between the two groups. The DMSO group exhibited enhanced levels of putrescine and glutathione and decreased levels of methionine and lysine. Additionally, the DMSO group exhibited alterations in 13 metabolic pathways involved in primary and secondary cellular metabolism. Among the 13 altered pathways, seven were downregulated and six were upregulated in the DMSO group. These results indicated a differential intracellular metabolic profile between the untreated and DMSO-treated biofilms. Hence, DMSO was demonstrated to affect the metabolic pathways of C. albicans. These results suggest that DMSO may influence the results of laboratory tests when it is used as a solvent. Hence, the use of DMSO as a solvent must be carefully considered in drug research, as the effect of the researched drugs may not be reliably translated into clinical practice.
Victims of a Human Tragedy or “Objects” of Migrant Smuggling? Media Framing of Greece’s Deadliest Migrant Shipwreck in Pylos’ Dark Waters
Authors: Kalfeli Panagiota (Naya) , Angeli Christina , Frangonikolopoulos Christos
Published: May 2024

Refugee and migration crises has been an integral part of the continuous and successive crises that the world has been experiencing. Media has played a crucial role in shaping public opinion over migration and asylum-seeking. Within this context, this paper aims to discuss Greek media coverage of the migrant shipwreck off the Greek coast of Pylos, in June 2023, in which more than 600 people mostly from Syria, Egypt, and Pakistan are thought to have drowned. Based on data from a quantitative content analysis and a sample of news stories stemming from the online version of five Greek news media outlets, representing diverse political spaces, a broader set of criteria for content analysis, including the absence of refugee and migrant voice in media content, dehumanization, absence of solutions and context, among many others, was used in order to explore how the Greek media framed what has been labeled as one of the deadliest migrant shipwrecks in the Mediterranean. Results revealed (i) frames of dehumanization, (ii) insufficient reporting of injustice and discrimination stemming from (state) structures and practices, and an (iii) overemphasis on migrant smuggling.
Quality of Life in Patients with Chronic Low Back Pain and Differences by Sex: A Longitudinal Study
Authors: Pericot-Mozo Xavier , Suñer-Soler Rosa , Reig-Garcia Glòria , Patiño-Masó Josefina , Sitjar-Suñer Miquel , Masià-Plana Afra , Bertran-Noguer Carme
Published: May 2024

Background: The experience of chronic low back pain has a significant impact on the quality of life of affected people, resulting in difficulties in performing basic activities of daily living. Aim: To study the perceived quality of life of people affected by chronic low back pain and the associated factors by sex. Methods: A prospective, longitudinal and observational design was used. Results: A total of 129 people (58.1% women) with chronic low back pain were studied. The mean pain intensity scores were of moderate severity (6.42 points), with a modest improvement at follow-up (6.17 points). Epidural nerve blocks were the most effective therapeutic intervention in reducing the intensity of pain. Participants described a negative perception of their health with regard to quality of life, with low scores for the two constructs both at baseline (health index, 0.444; perception of health, 38.76 points) and at follow-up (health index, 0.447; perception of health, 40.43 points). Participants had severe functional limitation scores (50.79 points). The results were significantly better among men. There was an inverse relationship between the average pain intensity (β = −0.304; p < 0.001), functional limitation (β = −0.466; p < 0.001) and mental health (β = −0.565; p < 0.001) and quality of life. Conclusions: The chronification of low back pain complicates people’s biopsychosocial adaptation to life. There is a longitudinal inverse association between pain and functional limitation and health-related quality of life.
Ceramic Dressings—A New Non-Pharmacological Therapeutic Option in the Management of Chronic Wounds?
Authors: Hecker Andrzej , Watzinger Nikolaus , Pignet Anna-Lisa , Michelitsch Birgit , Kotzbeck Petra , Kamolz Lars-Peter
Published: May 2024

A new ceramic dressing, free from active antimicrobial or pharmaceutical agents, uses physical binding mechanisms for its absorption capacities and bacterial-binding properties. The purpose of this study was to evaluate wound healing, bacterial-related retention, and diagnostic properties of ceramic dressings in patients with stagnated chronic wounds. Methods: In this monocentric, intra-individually controlled, prospective study, patients with conservatively treated refractory chronic wounds were enrolled. One week before the start of the application with ceramic dressing, it was ensured during a screening phase that chronic wounds showed less than a 10% reduction in wound size. During the 4-week ceramic dressing treatment wound size measurements, wound scoring, measurement of wound exudate amount, wound swabs, and ceramic dressing sonication (low-intensity ultrasound) were carried out. The sonication fluid of the removed ceramic dressing was used for analysis of bacterial retention and compared to wound swabs. Results: A total of 20 patients with a mean age of 64.6 years (±26.2) and 21 chronic wounds were included in this study. After a 4-week treatment, a significant reduction of median wound size from 1178 mm2 (range 104–6300) to 751.5 mm2 (range 16–4819) and better total wound scores were observed (p < 0.001). The sensitivity of bacteria detection was 90.7% in the sonication fluid from the ceramic dressings, while only 76.9% in the conventional wound swabs. Conclusion: The new ceramic dressing seems to have a positive impact on wound healing in chronic wounds. Bacteria-binding characteristics of the investigated ceramic dressing, in combination with its debridement, absorption, and detoxification properties, could contribute to its healing abilities. Based on those results, the investigated ceramic dressing seems to be a promising new treatment option for chronic wounds without the use of any active antimicrobial or pharmacological agents. Moreover, ceramic dressings can also be considered for microbiological diagnostic purposes.
Transformative Impact of Technology in Landscape Architecture on Landscape Research: Trends, Concepts and Roles
Authors: Shen Xiwei , Padua Mary G. , Kirkwood Niall G.
Published: May 2024

The role of technology in landscape architecture (TLA) has significantly evolved since the 19th century, increasingly integrating with digital tools and technologies in the 21st century. Despite its growing importance, there is a notable deficiency in the scholarly literature regarding the progression of TLA trends and their interplay with the core domains and research themes within landscape research. The influence of TLA on landscape research remains ambiguous, especially concerning its ability to generate new knowledge and impact design and sustainability practices. Furthermore, there is a critical need to delineate how TLA differs from allied general digital technology tools and to identify specific specializations that are emerging within the TLA field. To explore the above gaps, this study utilized a mixed methods approach involving secondary data from peer-reviewed publications, primary data from the archival research of winning projects, and expert interviews based on the two major research types of “Research through Design (RTD)” and “Research for Design (RFD)” to explore the TLA’s contribution. This research is significant as it: (1) identified the trend of TLA; (2) conceptualized the TLA, and (3) identified its role in relation to the core domains and research themes of landscape research.
A Calculation and Optimization Method for the Theoretical Reclamation Timing of Cropland
Authors: Yin Hejian , Guo Guangli , Li Huaizhan , Wang Tiening
Published: May 2024

In mining areas with high groundwater tables, mining subsidence can lead to the inundation of cropland by water, causing damage to cropland and posing a threat to national food security. The implementation of concurrent mining and reclamation techniques can effectively enhance the reclamation rate of cropland. This technique requires engineers to initiate reclamation measures before cropland waterlogging occurs. Therefore, when mining a panel underground, an accurate calculation of the time when cropland becomes waterlogged, known as the theoretical reclamation timing, is crucial. To address this issue, this study proposes a computational method for the theoretical reclamation timing of cropland under the conditions of single-panel mining based on intelligent optimization algorithms. In addition, this paper also proposes an optimization method for the theoretical reclamation timing of cropland within a district based on an intelligent optimization algorithm. Utilizing this method makes optimizing the layout of multiple panels possible, thereby delaying the theoretical reclamation timing for cropland within a district. This approach aims to shorten the duration of reclamation projects and minimize their interference with agricultural activities. Through experimental validation, this paper demonstrates the reliability of these two methods. This study is beneficial for the rational planning of reclamation projects.
Characterization Methods for Nanoparticle–Skin Interactions: An Overview
Authors: Dzyhovskyi Valentyn , Romani Arianna , Pula Walter , Bondi Agnese , Ferrara Francesca , Melloni Elisabetta , Gonelli Arianna , Pozza Elena , Voltan Rebecca , Sguizzato Maddalena , Secchiero Paola , Esposito Elisabetta
Published: May 2024

Research progresses have led to the development of different kinds of nanoplatforms to deliver drugs through different biological membranes. Particularly, nanocarriers represent a precious means to treat skin pathologies, due to their capability to solubilize lipophilic and hydrophilic drugs, to control their release, and to promote their permeation through the stratum corneum barrier. A crucial point in the development of nano-delivery systems relies on their characterization, as well as in the assessment of their interaction with tissues, in order to predict their fate under in vivo administration. The size of nanoparticles, their shape, and the type of matrix can influence their biodistribution inside the skin strata and their cellular uptake. In this respect, an overview of some characterization methods employed to investigate nanoparticles intended for topical administration is presented here, namely dynamic light scattering, zeta potential, scanning and transmission electron microscopy, X-ray diffraction, atomic force microscopy, Fourier transform infrared and Raman spectroscopy. In addition, the main fluorescence methods employed to detect the in vitro nanoparticles interaction with skin cell lines, such as fluorescence-activated cell sorting or confocal imaging, are described, considering different examples of applications. Finally, recent studies on the techniques employed to determine the nanoparticle presence in the skin by ex vivo and in vivo models are reported.
Enhancement of Catalytic Efficiency of Enzymatic Redox Reactions by Composing Horseradish Peroxidase-Modified Electrode with Ionic Liquids
Authors: Noritomi Yasuko , Kuboki Takashi , Noritomi Hidetaka
Published: May 2024

We have kinetically estimated the enzymatic redox reaction at the horseradish peroxidase (HRP)-modified electrode combined with ionic liquids by adding N-(2-methoxythethyl)-N-methylpyrrolidinium bis(trifluoromethane sulfonyl)imide (MEMPTFSI) to HRP/carbon paste (CP)/Ketjenblack EC600JC (EC). The fluctuation of the steady-state reduction current of HRP at the HRP/CP-modified electrode progressively increased as the applied potential was lowered. The enzymatic redox reaction with hydrogen peroxide as a substrate at the HRP/CP/EC/MEMPTFSI-modified electrode and the HRP/CP-modified electrode could be correlated by the Michaelis–Menten equation. The Michaelis constant of the enzymatic redox reaction at the HRP/CP/EC/MEMPTFSI-modified electrode was the same as that at the HRP/CP-modified electrode. On the other hand, the turnover number of the enzymatic redox reaction at the HRP/CP/EC/MEMPTFSI-modified electrode was six times larger than that at the HRP/CP-modified electrode. Consequently, the specificity constant of the enzymatic redox reaction at the HRP/CP/EC/MEMPTFSI-modified electrode was much higher than that at the HRP/CP-modified electrode.
The Principal-Agent Theoretical Ramifications on Digital Transformation of Ports in Emerging Economies
Authors: Sakita Benjamin Mosses , Helgheim Berit Irene , Bråthen Svein
Published: May 2024

Background: Scholarly literature indicates a slow pace at which maritime ports fully embrace digital transformation (DT). The reasons to this are largely anecdotal and lack solid empirical grounding. This inhibits an overall understanding of DT’s tenets and the development of evidence-based policies and targeted actions. Methods: This study deployed a qualitative case study strategy to unpack the challenges of undertaking DT through the lens of principal-agent theory (PAT). Results: Analysis of data collected through 13 semi-structured interviews from a port’s value chain stakeholders revealed five thematic challenges that contradict successful implementation of DT. These included interagency constraints and system ownership tussles; system sabotage and prevalent corruption; prevalent human agency in port operations; cultural constraints; and political influence on port governance. Conclusions: To address these challenges, the study proposes a four-stage empirically grounded DT strategy framework that guides both practitioners and policymakers through DT endeavors. The framework includes: (1) the port’s value chain mapping, (2) stakeholder engagement, (3) resource mobilization, and (4) effective monitoring. For scholars, we provide an avenue for testing statistical significance of association and causality among the identified challenges.
Effects of Multidimensional Carbon-Based Nanomaterials on the Low-Carbon and High-Performance Cementitious Composites: A Critical Review
Authors: Gao Xiumei , Fang Wujun , Li Weiwen , Wang Peng , Khan Kashan , Tang Yihong , Wang Teng
Published: May 2024

Cementitious composites are ubiquitous in construction, and more and more research is focused on improving mechanical properties and environmental effects. However, the jury is still out on which material can achieve low-carbon and high-performance cementitious composites. This article compares the mechanical and environmental performance of zero-dimensional fullerenes, one-dimensional carbon nanotubes (CNTs), two-dimensional graphene oxide (GO), and three-dimensional nano-graphite platelets (NGPs) on cementitious composites. The literature review shows that two-dimensional (2D) GO has the best mechanical and environmental performance, followed by 3D NGPs, 1D CNTs, and 0D fullerenes. Specifically, GO stands out for its lower energy consumption (120–140 MJ/kg) and CO2 emissions (0.17 kg/kg). When the optimal dosage (0.01–0.05 wt%) of GO is selected, due to its high specific surface area and strong adhesion to the matrix, the compressive strength of the cementitious composites is improved by nearly 50%. This study will help engineers and researchers better utilize carbon-based nanomaterials and provide guidance and direction for future research in related fields.
Enhancing the Performance of Hemihydrate Phosphogypsum by the Collaborative Effects of Calcium Hydroxide and Carbonation
Authors: Huang Jiawen , Liu Zanqun , Wei Xiangsong , Ding Xiaojiang , Zhu Jiahui , Zhao Yilin , Iqbal Babar , Guo Shulai
Published: May 2024

Normally, the acidic impurities in hemihydrate phosphogypsum (HPG) must be neutralized when HPG is utilized, and a little amount of calcium hydroxide (CH) is the best choice. In this paper, the effects of excessive CH (5 wt.%, 10 wt.%, 15 wt.% and 20 wt.% of HPG) for carbonation curing on the performance of hardened HPG paste were studied. According to the results of macro tests and microanalyses of XRD, TG, SEM-EDS, MIP and N2 physisorption, it could be verified that CaF2, Ca3(PO4)2 and a large amount of nanoscale CaCO3 crystals were produced as a result of neutralization and carbonation, and the compressive strength and the water resistance of carbonated HPG + CH paste were significantly improved due to the effects of nanoscale CaCO3 crystals on pore refinement and the coverage on the surfaces of gypsum crystals of the hardened paste. Therefore, this study suggests a feasible and green method for recycling HPG/PG, with the collaborative effects of neutralization, performance enhancement and reductions in CO2 emissions.
Impact of Cutting Data on Cutting Forces, Surface Roughness, and Chip Type in Order to Improve the Tool Operation Reliability in Sintered Cobalt Turning
Authors: Franczyk Emilia , Zębala Wojciech
Published: May 2024

The authors present the results of laboratory tests analysing the impact of selected cutting data and tool geometry on surface quality, chip type and cutting forces in the process of orthogonal turning of sintered cobalt. The selected cutting data are cutting speed and feed rate. During the experiments, the cutting speed was varied in the range of vc = 50–200 m/min and the feed rate in the range of f = 0.077–0.173 mm/rev. In order to measure and acquire cutting force values, a measuring setup was assembled. It consisted of a Kistler 2825A-02 piezoelectric dynamometer with a single-position tool holder, a Kistler 5070 signal amplifier and a PC with DynoWare software (Version 2825A, Kistler Group, Winterthur, Switzerland)). The measured surface quality parameters were Ra and Rz. The components of the cutting forces obtained in the experiment varied depending on the feed rate and cutting speed. The obtained test results will make it possible to determine the optimal parameters for machining and tool geometry in order to reduce the machine operating time and increase the life of the cutting insert during the turning of sintered cobalt, which will contribute to sustainable technology.
Investigation of the Effect of Blended Aggregate on the Strength and Drying Shrinkage Characteristics of Alkali-Activated Slag Mortar
Authors: Kang Choonghyun , Park Yongmyung , Kim Taewan
Published: May 2024

To reduce drying shrinkage of AASC mortar (AASM), mixed aggregate mixed with river sand (RS) and silica sand in three sizes was used to investigate the effect of the physical properties of mixed aggregate on shrinkage reduction. A mixture of river sand (0.2–0.8 mm), S1 (2.5–5.0 mm), S2 (1.6–2.5 mm), and S3 (1.21–160 mm) had river sand–silica sand mean diameter ratios (dr) of 7.68 (S1/RS), 3.75 (S2/RS), and 3.02 (S3/RS). The compressive strength and drying shrinkage characteristics of mixed aggregates according to fineness modulus, surface area, bulk density, and pore space were investigated. It had the highest bulk density and lowest porosity at a substitution ratio of 50%, but the highest strength was measured at a substitution ratio of 50% or less. High mechanical properties were shown when the fineness modulus of the mixed aggregate was in the range of 2.25–3.75 and the surface area was in the range of 2.25–4.25 m2/kg. As the substitution rate of silica sand increased, drying shrinkage decreased. In particular, the drying shrinkage of RS + S1 mixed aggregate mixed with S1 silica sand, which had the largest particle size, was the smallest. When silica sand or river sand was used alone, the drying shrinkage of the sample manufactured only with S1, which has the largest particle size of silica sand, was the smallest among all mixes. Compared to RS, at a 5% activator concentration, drying shrinkage was reduced by approximately 40% for S1, 27% for S2, and 19% for S3. At a 10% concentration, S1 showed a reduction effect of 39%, S2 by 28%, and S3 by 13%. As a result of this study, it was confirmed that the drying shrinkage of AASM could be reduced simply by controlling the physical properties of the aggregate mixed with two types of aggregate. This is believed to have a synergistic effect in reducing drying shrinkage when combined with various reduction methods published in previous studies on AASM shrinkage reduction. However, additional research is needed to analyze the correlation and influencing factors between the strength, pore structure, and drying shrinkage of AASM using mixed aggregate.
Molecular Dynamics Simulation and the Regeneration and Diffusion Effects of Waste Engine Oil in Aged Asphalt Binder
Authors: Sun Yuxuan , Cannone Falchetto Augusto , Zhang Fan , Wang Di , Chen Wei
Published: May 2024

In recent years, the potential of waste engine oil (WEO) as a rejuvenator for aged asphalt binders has gained significant attention. Despite this interest, understanding WEO’s regeneration mechanism within aged asphalt binders, particularly its diffusion behavior when mixed with both aged and virgin asphalt binders, remains limited. This study adopts a molecular dynamics approach to constructing models of virgin, aged, and rejuvenated asphalt binders with different WEO contents (3%, 6%, 9%, and 12%). Key properties such as the density, glass transition temperature, cohesive energy density, solubility parameter, viscosity, surface free energy, fractional free volume, and diffusion coefficient are simulated. Additionally, models of rejuvenated asphalt binder are combined with those of aged asphalt binder to investigate mutual diffusion, focusing on the impact of WEO on the relative concentration and binding energy. The findings reveal that WEO notably decreased the density, viscosity, and glass transition temperature of aged asphalt binders. It also improved the molecular binding within the asphalt binder, enhancing crack resistance. Specifically, a 9% WEO content can restore the diffusion coefficient to 93.17% of that found in virgin asphalt binder. Increasing the WEO content facilitates diffusion toward virgin asphalt binders, strengthens molecular attraction, and promotes the blending of virgin and aged asphalt binders.
Effect of the Inorganic Modification Mode on the Mechanical Properties of Rubber Recycled Concrete
Authors: Liu Leifei , Zong Jingmei , Hou Xueqian , Liu Xiaoyan
Published: May 2024

The reasonable and effective application of waste tires and discarded concrete in concrete is an important branch of green concrete development. This paper investigates the effects of the inorganic modification mode on the basic mechanical properties of rubber recycled concrete based on indoor tests. Inorganic modification, such as water washing, acid washing, and alkaline washing modification, was mainly used to treat and modify rubber particles. The factors affecting the compressive strength, the splitting tensile strength, the flexural strength, the axial compressive strength, and the modulus of elasticity of modified rubber recycled concrete were analyzed. The study results show that the incorporation of recycled aggregates and rubber reduced the mechanical properties of concrete, with the compressive and splitting tensile strengths showing the greatest reductions of 27.36% and 27.24%, respectively. Three modification methods significantly improved the mechanical properties of rubber recycled concrete. The alkali washing modification method was the most effective, maximally improving the mechanical properties of rubber recycled concrete by 7.53–15.51%. The effects of the three modifications on the mechanical properties of concrete were ranked as follows: alkali washing > acid washing > water washing. This study provides a data basis for the practical application of rubber recycled concrete in engineering and a test basis for the development of green concrete.
Enhancing the Thermal Resistance of UV-Curable Resin Using (3-Thiopropyl)polysilsesquioxane
Authors: Pakuła Daria , Sztorch Bogna , Topa-Skwarczyńska Monika , Gałuszka Karolina , Ortyl Joanna , Marciniec Bogdan , Przekop Robert E.
Published: May 2024

This study delineates a methodology for the preparation of new composites based on a photocurable urethane-acrylate resin, which has been modified with (3-thiopropyl)polysilsesquioxane (SSQ-SH). The organosilicon compound combines fully enclosed cage structures and incompletely condensed silanols (a mixture of random structures) obtained through the hydrolytic condensation of (3-mercaptopropyl)trimethoxysilane. This process involves a thiol-ene “click” reaction between SSQ-SH and a commercially available resin (Ebecryl 1271®) in the presence of the photoinitiator DMPA, resulting in composites with significantly changed thermal properties. Various tests were conducted, including thermogravimetric analysis (TGA), Fourier transmittance infrared spectroscopy (FT-IR), differential scanning calorimetry (Photo-DSC), and photoreological measurement mechanical property, and water contact angle (WCA) tests. The modification of resin with SSQ-SH increased the temperature of 1% and 5% mass loss compared to the reference (for 50 wt% SSQ-SH, T5% was 310.8 °C, an increase of 20.4 °C). A composition containing 50 wt% of SSQ-SH crosslinked faster than the reference resin, a phenomenon confirmed by photorheological tests. This research highlights the potential of new composite materials in coating applications across diverse industries. The modification of resin with SSQ-SH not only enhances thermal properties but also introduces a host of functional improvements, thereby elevating the performance of the resulting coatings.