bluuebunny/crossref_metadata_2025 huggingface dataset:
Surrounding landscape structures, rather than habitat age, drive genetic variation of typical calcareous grassland plant species
Authors: Lehmair Theresa Anna , Pagel Ellen , Poschlod Peter , Reisch Christoph
Published: September 2020

Context

Land use change reduced calcareous grasslands throughout Europe during the last decades. Subsequent fragmentation and habitat deterioration led, moreover, to a massive biodiversity decline. To counteract this alarming development, a clear understanding of genetic variation patterns, as fundamental level of biodiversity, becomes inevitable.

Objectives

The aim of our study was to identify the drivers of genetic variation in common calcareous grassland plant species. More specifically, we tested whether genetic diversity or differentiation ofAsperula cynanchica,Campanula rotundifolia, andLinum catharticumdepend on habitat age, landscape structure, habitat quality, and/or population size.

Methods

We investigated 912 individuals, 304 per study species, from 19 calcareous grasslands across the Swabian Alb in Baden-Württemberg (Germany) using AFLP analyses.

Results

We observed no significant influence of habitat age on genetic diversity and differentiation. Habitat quality also had no impact on genetic diversity and population size only showed weak effects. However, genetic diversity strongly depended on landscape structure represented by distance to the nearest settlement, total area of surrounding calcareous grasslands, and their connectivity.

Conclusions

Migratory sheep herding is considered as main land use in calcareous grasslands on the Swabian Alb and thus, landscape structures in the study region may describe movement patterns of grazing livestock. In this study, genetic variation in calcareous grassland populations was strongly affected by surrounding landscape structures and subsequent grazing patterns. Therefore, we assume that moderate grazing intensities over the long term may increase levels of genetic diversity, whereas periods of overgrazing or abandonment could lower genetic diversity.
Evaluation of the safety and efficacy of low-dose rasburicase in critically ill children with haematological malignancies
Authors: Pei Yuxin , Li Yu , Liang Yujian , Xu Lingling , Huang Xueqiong , Li Yijuan , Tang Wen , Jiang Xiaoyun
Published: September 2020

Background The recommended dose of rasburicase is quite expensive, thus limiting its use. Whether a lower dose of rasburicase would be equally effective for critically ill children, who often have more complicated situations and a higher risk of hospital death, is still unknown. Objective To explore the safety and efficacy of low-dose rasburicase in critically ill children with haematological malignancies who are at high risk of tumour lysis syndrome. Setting A single-centre retrospective cohort study. Method Children with haematological malignancies who had a history of rasburicase exposure during an intensive care unit stay were enrolled. Patients were divided into two groups according to the initial dosage of rasburicase: the standard-dose group (> 0.1 mg/kg/day) and the low-dose group (≤ 0.1 mg/kg/day). The adverse events and short-term prognosis of the two groups were compared. Results Thirty-seven children were selected, 22 in the standard-dose group and 15 in the low-dose group. The most common tumour type was Burkitt’s lymphoma (81%), followed by acute lymphoblastic leukaemia (11%). All patients were at high risk of tumour lysis syndrome, and 73% of them had 3 or more tumour lysis syndrome risk factors. The uric acid levels of 90% of patients with hyperuricaemia returned to the normal range within 12 h (100% in the standard-dose group and 75% in the low-dose group, P = 0.083). Eighty-four percent of patients presented serious complications, including tumour lysis syndrome (73%), acute kidney injury (59%), renal replacement treatment (24%), respiratory failure (24%), disseminated intravascular coagulation (16%) and heart failure (11%). There was no significant difference in the incidence of serious complications between the two groups. The overall 7-day and 28-day survival rates after intensive care unit admission were 86% and 84%, respectively. The average length of stay in the intensive care unit was 9.92 ± 5.13 days. Neither the short-term mortality nor the length of stay in the intensive care unit were significantly different between the two groups. Conclusion Low-dose rasburicase is effective and may be an acceptable choice for critically ill children with haematological malignancies.
The sociocognitive approach in critical discourse studies and the phenomenological sociology of knowledge: intersections
Authors: Gyollai Daniel
Published: September 2020

This article argues that phenomenological sociology has great potential to provide a strong theoretical support to the Sociocognitive Approach (SCA) in Critical Discourse Studies. SCA is interested in the interconnections between knowledge, discourse and society while placing subjectivity in the centre of its framework. It looks into the correlative relationship between personal- and socially shared knowledge, and the significance of these correlations to discourse production and interpretation. Analogously, phenomenological sociology explores the interrelated structures of subjectivity, knowledge and the social world. It systematically analyses the conditions and forms of intersubjective understanding and the mutually constitutive relationship between subjective- and objective knowledge. Given the considerable overlap between the subject matter of phenomenological sociology and that of SCA, the purpose of the article is to draw the attention of critical discourse analysts to a neglected but extremely resourceful field. Following a brief introduction to SCA, the article will address some of SCA’s key concepts in conjunction with the phenomenological-sociological insight.
The Acceptability and Feasibility of Using Text Messaging to Support the Delivery of Physical Health Care in those Suffering from a Psychotic Disorder: a Review of the Literature
Authors: Griffiths Henry
Published: September 2020

Those suffering with serious mental illness (SMI), such as psychotic disorders, experience life expectancy 15 years shorter than the general population. Cardiovascular disease is the biggest cause of death in those with psychotic disease and many risk factors may be limited by healthy lifestyle choices. Text messaging interventions represent mobile health (mHealth), a nascent way to deliver physical health care to those suffering with a psychotic disorder. This paper aims to review the literature on the feasibility of text messaging to support the delivery of physical health care in those with a psychotic disorder. A thorough electronic database literature review of Medline via Ovid, Embase, APA Psycinfo, Scopus, Cochrane and Web of Science was conducted. Articles were included if text messaging was used as an intervention targeting the physical health of patients with psychotic disorders. A final sample of 11 articles satisfied the eligibility criteria, of which, 3 were ongoing randomised controlled trials. Of the 8 completed trials, all demonstrated the promising feasibility of text messaging, assessed via quotes, conversation samples, response rates, questionnaires or directly based on physical results. 36% of studies analysed those with schizophrenia or schizoaffective disorder, 55% with SMI and 9% with schizophrenia and psychotic disorders, mood disorders or anxiety disorders. Text messaging was used as motivation or reminders (91%), service delivery (27%) or social support (27%) with studies targeting multiple themes simultaneously. This review highlights compelling evidence for the feasibility of text messaging for improvement of physical health in those suffering with psychotic disorders.
Predictors of quality of life among youths in foster care—a 5-year prospective follow-up study
Authors: Larsen Marit , Goemans Anouk , Baste Valborg , Wilderjans Tom F. , Lehmann Stine
Published: September 2020

Purpose

Few studies have investigated possible predictors of positive outcomes for youths in foster care. The aim of this prospective follow-up study was to examine quality of life (QoL) among youths in foster care and to assess whether contextual and child factors predicted QoL.

Methods

Online questionnaires were completed by carers in Norway in 2012 (T1, n = 236, child age 6–12 years) and by youths and carers in 2017 (T2, n = 405, youth age 11–18 years). We received responses on 116 of the youths at both T1 and T2, and our final sample consisted of 525 youths with responses from T1 and/or T2. Child welfare caseworkers reported preplacement maltreatment and service use at T1. We assessed mental health and prosocial behavior at T1 by having carers complete the Strength and Difficulties Questionnaire and QoL at T2 with youth-reported KIDSCREEN-27. We analyzed the data using descriptive statistics, t-tests and multiple linear regressions, and we used multiple imputation to handle missing data.

Results

Youths in foster care had lower QoL across all dimensions compared to a Swedish general youth sample. QoL scores among our sample were similar to Norwegian youths with ill or substance abusing parents and to European norm data. Youths reported the highest QoL scores on the parent relations and autonomy dimension. Male gender, younger age, kinship care and prosocial behavior five years earlier predicted higher QoL.

Conclusion

Similar to other at-risk youths, youths in foster care seem to have lower QoL than the general Scandinavian population. Despite early adversities, they had good relations with their current carers. Adolescent girls seem especially vulnerable to low QoL and might need extra support to have good lives in foster care.
Generalizing algebraically defined norms
Authors: Fiorenza Alberto , Talponen Jarno
Published: September 2020

We extend the algebraic construction of finite dimensional varying exponent $$L^{p(\cdot )}$$

L

p
(
·
)

space norms, defined in terms of Cauchy polynomials to a more general setting, including varying exponent $$L^{p(\cdot )}$$

L

p
(
·
)

spaces. This boils down to reformulating the Musielak–Orlicz or Nakano space norm in an algebraic fashion where the infimum appearing in the definition of the norm should become a (uniquely attained) minimum. The latter may easily fail, as turns out, and in this connection we examine the Fatou type semicontinuity conditions on the modulars. Norms defined by ODEs are applied in studying such semicontinuity properties of $$L^{p(\cdot )}$$

L

p
(
·
)

space norms with $$p(\cdot )$$

p
(
·
)

unbounded.
The experiences and needs of couples affected by prostate cancer aged 65 and under: a qualitative study
Authors: Collaço Nicole , Wagland Richard , Alexis Obrey , Gavin Anna , Glaser Adam , Watson Eila K.
Published: September 2020

Purpose

Prostate Cancer (PCa) is often considered to be an illness affecting older men, however the prevalence in younger men (<=65 years) is rising. Diagnosis and treatment for PCa can have a significant impact on the lives of both the man with PCa and his partner. This study explored the experiences and needs of younger men and their partners affected by PCa. The findings will be used to inform service provision and develop interventions appropriate to need.

Methods

Participants were recruited from respondents to a national PROMS study (Life After Prostate Cancer Diagnosis (LAPCD), who indicated on completed questionnaires their willingness to be interviewed. Semi-structured telephone interviews were conducted with twenty-eight couples, separately (56 participants). Data were analysed using the Framework Method.

Results

Following the diagnosis of PCa, couples’ experienced changes in their intimate relationships, parental/familial roles, work and finances, and social connections and activities. Couples adopted a range of strategies and behaviours to help their adjustment to PCa, such as communicating with each other, distancing, distraction, and adopting a positive mindset towards PCa. This, in turn, influenced how their identity as a couple evolved.

Conclusions

Following a diagnosis of PCa, the identity of couples are continually evolving. It is important that these couples are provided with the appropriate information, support and resources to help them transition along the cancer pathway.

Implications for Cancer Survivors

Key areas of support identified for younger couples include: 1) couple focused support programme to foster relationship strategies/behaviours that facilitate couple adjustment; 2) age-specific support, e.g. ‘buddying systems’ connecting younger couples affected by PCa and providing them with tailored information (written/online/app).
Can probiotics, prebiotics and synbiotics improve functional outcomes for older people: a systematic review
Authors: Coutts L. , Ibrahim K. , Tan Q. Y. , Lim S. E. R. , Cox N. J. , Roberts H. C.
Published: September 2020

Purpose

Research evaluating the effect of probiotics, prebiotics and synbiotics (PPS) on laboratory markers of health (such as immunomodulatory and microbiota changes) is growing but it is unclear whether these markers translate to improved functional outcomes in the older population. This systematic review evaluates the effect of PPS on functional outcomes in older people.

Methods

We conducted a systematic review of the effect of PPS in older adults on functional outcomes (physical strength, frailty, mood and cognition, mortality and receipt of care). Four electronic databases were searched for studies published since year 2000.

Results

Eighteen studies (including 15 RCTs) were identified. One of five studies evaluating physical function reported benefit (improved grip strength). Two analyses of one prebiotic RCT assessed frailty by different methods with mixed results. Four studies evaluated mood with no benefit reported. Six studies evaluated cognition: four reported cognitive improvement in participants with pre-existing cognitive impairment receiving probiotics. Seven studies reported mortality as a secondary outcome with a trend to reduction in only one. Five studies reported length of hospital stay but only two peri-operative studies reported shorter stays.

Conclusion

There is limited evidence that probiotics may improve cognition in older people with pre-existing cognitive impairment but no clear evidence of benefit of PPS on physical function, frailty, mood, length of hospitalisation and mortality. Larger studies with more homogenous interventions, accounting for confounding factors, such as diet, co-morbidities and medications, are required. There is currently inadequate evidence to recommend PPS use to older people in general.

PROSPERO registration number

PROSPERO registration number is CRD42020173417. Date of PROSPERO registration: 01/05/20.
Functional capacity, lung function, and muscle strength in patients undergoing hematopoietic stem cell transplantation
Authors: Silva T.C. , Silva P.O. , Morais D.S. , Oppermann C.Z. , Penna G.B. , Paz A. , Ziegler B.
Published: September 2020

Objective/Background:

Hematopoietic stem cell transplantation (HSCT) is a treatment for benign and malignant hematological diseases. These aggressive treatments cause reduced levels of physical activity, decreased lung function, and worse quality of life. Alterations in pulmonary function tests before HSCT are associated with the risk of respiratory failure and early mortality. The objective of this study was to evaluate functional capacity and lung function before and after HSCT and identify the predictors of mortality after 2 years.

Methods:

A prospective cohort study was carried out with individuals with oncohematological diseases. The evaluations were carried out in two moments during hospitalization and at hospital discharge. Follow-up was carried out after 48 months. Assessments were carried out on 34 adults, using spirometry, manovacuometry, 6-Minute Walk Test (6MWT), Handgrip Strength Test, and 30-Second Chair Stand Test (30-s CST).

Results:

There was a statistically significant reduction for the variables in forced vital capacity, forced expiratory volume predicted in the 1st second, Tiffeneau index, handgrip strength, and distance covered (% predicted) on the 6MWT (p < .05). There was a significant difference in the 30-s CST when individuals were compared according to the type of transplant. We found that a 10% reduction in the values of maximum inspiratory pressure (MIP) can predict an increased risk for mortality.

Conclusions:

Individuals undergoing HSCT have reduced functional capacity, lung function, and muscle strength during the hospitalization phase. Reduction in the values of MIP increases the risk of nonrelapse mortality.
The Association of Finger Growth Plate Injury History and Speed Climbing in Youth Competition Climbers
Authors: Meyers Rachel N. , Howell David R. , Provance Aaron J.
Published: September 2020

Introduction

Finger growth plate injuries are the most common injury among youth climbers, and the association between these injuries and speed climbing, a mandatory discipline in the 2021 Olympics, has not been examined previously. Our primary purpose was to examine the demographic and training characteristics of adolescent competition climbers who reported a history of a finger growth plate injury compared to those who did not report a history of a finger growth plate injury. Our secondary purpose was to determine whether training characteristics differed between adolescent competition climbers who did and did not report speed climbing.

Methods

Our study was a cross-sectional study design. We surveyed adolescent climbers who competed in the 2017 USA Climbing Sport and Speed Youth National Championships. Questions assessed climbing injury history and current rock-climbing training characteristics.

Results

Two-hundred sixty-seven adolescent competition climbers, 14±3 (9–18) y of age (mean±SD with range), completed the survey. Those with a history of a finger growth plate injury reported greater approximate time spent speed climbing throughout the year (β=1.28, 95% CI 0.11–2.46, P=0.032) and training regularly on the International Federation of Sport Climbing speed wall (adjusted odds ratio=3.95, 95% CI 1.14–13.7, P=0.031).

Conclusions

Training regularly at practices on the speed wall was associated with a self-reported history of finger growth plate injuries among elite youth competition climbers. Speed climbing should be limited, especially during periods of rapid growth.
Are Trekking Poles Helping or Hindering Your Hiking Experience? A Review
Authors: Hawke Ashley L. , Jensen Randall L.
Published: September 2020

Hiking is a common recreational activity that provides numerous health benefits, such as reduced risk of heart disease, reduced blood pressure, and improved cardiorespiratory fitness. The use of specifically designed trekking poles has become popular among participants seeking to alleviate sore knees and increase balance and stability while walking. This review provides an overview of physiologic and biomechanical responses elicited when trekking poles are used during outdoor activities, such as hiking or Nordic walking, and discusses the clinical implications of the use of trekking poles. Google Scholar, PubMed, and ScienceDirect databases, as well as university library catalogues, were searched for literature published between 1980 and 2019. The keywords used to search the literature were hiking poles, trekking poles, and Nordic walking and their combination with physiological responses, ground reaction forces, joint forces, spatiotemporal parameters, kinematics, electromyography, and/or balance. The related topics included the academic disciplines of biomechanics, sports science, and wilderness medicine. Reference lists of located studies were also reviewed for additional sources. During free, unloaded walking, users should compare the cost and benefit of using poles: Trekking poles decrease lower extremity loading and forces but increase cardiovascular demand. When carrying a large external load, trekking poles may offer benefit by decreasing lower extremity muscle activity and increasing balance and stability.
Genetic variation in CD36 is associated with dietary intake in Korean males
Authors: Choi Jeong-Hwa
Published: September 2020

Fat is one of the six types of taste. Perceived taste intensity could affect the preference for a food and whether or not it is consumed. Cluster of differentiation 36 (CD36) translocates fatty acids on the cellular membrane and is involved in the oral fat-sensing mechanism. Therefore, genetic variation rs1761667 in CD36 is known to be associated with the perception of fat taste and, hence, its dietary intake. This study examined whether CD36 rs1527479 T>C, a proxy of rs1761667, is associated with fat intake and related dietary behaviour in Koreans. Using the data of the Ansan/Ansung Study, a part of the Korean Genome Epidemiology Study, the association of rs1527479 with the intake of macronutrients, including fat and selected foods, and fat-related dietary behaviours were investigated in 3194 males and 3425 females grouped by their degree of obesity. The findings suggested that rs1527479 did not have a meaningful effect on the intake of fat or other macronutrients or on the selection of food among non-obese females and males. However, in males with obesity, the genetic variation showed a significant association with vegetable intake. Obese males with the mutant CC genotype had substantially lower cruciferous vegetable consumption (adjusted P = 0·0015) than individuals with the TT and CT genotypes. Rs1527479 had no significant effect on the frequency of consuming fried foods or commonly used types of seasoning and cooking oils. In conclusion, CD36 genetic variation was associated with the intake of cruciferous vegetables but not fat intake in obese Korean males.
REAL HYPERSURFACES IN COMPLEX SPACE FORMS ATTAINING EQUALITY IN AN INEQUALITY INVOLVING A CONTACT δ-INVARIANT
Authors: SASAHARA TORU
Published: September 2020

We investigate real hypersurfaces in nonflat complex space forms attaining equality in an inequality involving the contact δ-invariant δc(2) introduced by Chen and Mihai in [3].
To Save Whom They Can: Another Look at Philo and Missionary Deceit
Authors: Macdonald A. D.
Published: September 2020

Henry Chadwick proposed in the 1960s that Philo's Questions and Answers in Genesis 4.69 is important for understanding Paul's mission strategy in 1 Cor 9. In 2011 David J. Rudolph revisited that ‘missionary-apologetic’ reading of QG 4.69 in a discussion of Paul's observance of the Torah but refrained from drawing firm conclusions. This article subjects the missionary-apologetic hypothesis to closer scrutiny, especially regarding its plausibility as a reading of Philo. It argues that Chadwick's hypothesis lacks both evidence and explanatory power. QG 4.69, therefore, contributes little to our understanding of 1 Cor 9 and of Paul's missionary strategy and Torah observance.
Public and Private Space and Action in the Early Roman Period
Authors: Hylen Susan E.
Published: September 2020

Scholars have often explained discrepancies in evidence for women's participation in the early church by reference to the gendering of public and private spaces. Public spaces were coded male, and when churches moved into these spaces, women's leadership was disavowed. This article rejects the usefulness of the public/private dichotomy as an explanatory tool, arguing that the modern sense in which these terms are used was anachronistic to the New Testament period. The overlap between public functions and space that the modern concept of the ‘public sphere’ takes for granted did not exist in the ancient world. Public functions often occurred in household spaces, and functions considered private also took place outside homes. For these reasons, scholars should look for new language that better describes the ancient patterns.
Methodological considerations when piloting an interview protocol: the example of Syrian asylum seekers in France
Authors: Saddour Inès
Published: September 2020

This article discusses some methodological issues that arose when analysing data collected in a pilot study of the SOFRA project. We aimed at piloting a semi-structured interview protocol designed to collect qualitative data with nine Syrian asylum seekers and refugees studying French at university, using an interview schedule that targeted, among other things, information about learners’ interaction opportunities and attitudes about their new environment and learning experiences. Analysing the manners in which the interviewer asked the questions and coped with comprehension difficulties, as well as the way the interviewees responded to the questions, led to the identification of a number of problems that are partly related to question type and wording. The article concludes with a reflection on how to elicit relevant answers during a semi-structured interview with migrant learners.
Return temperature after heat shock affects the production of tetraploids in the yellowtail tetra Astyanax altiparanae
Authors: Martins Leandro Freitas , Hilbig Cleonice Cristina , Yasui George Shigueki , Monzani Paulo Sérgio , Senhorini José Augusto , Nakaghi Laura Satiko Okada , do Nascimento Nivaldo Ferreira
Published: September 2020

The aim of this study was to evaluate different post-shock temperatures for tetraploid induction in the yellowtail tetra Astyanax altiparanae. Newly fertilized eggs were divided into four groups, three were submitted to heat shock (40°C for 2 min) at 24 min post-fertilization (mpf) and another group remained without shock (control). Groups submitted to temperature shock were further separated at the following temperatures: 22°C, 26°C and 28°C. Survival among embryonic development was counted and at hatching the ploidy was analyzed by flow cytometry. The results showed that the post-shock temperature affects the parameters analyzed and, therefore, must be considered for optimization of the production of tetraploid in A. altiparanae. Those data are innovative and could be used in future studies of basic biology in this species.
CONVERGENCE AND DIVERGENCE: A NEW APPROACH, NEW DATA, AND NEW RESULTS
Authors: Battisti Michele , di Vaio Gianfranco , Zeira Joseph
Published: September 2020

Recently, Penn World Tables include new data that enable calculation of total factor productivity in addition to output for a large set of countries. We use these new data to examine convergence and divergence across countries by applying a new approach, which differentiates between the dynamics of output and of productivity. Our empirical results lead to two main new contributions to the literature. The first is on the interpretation of “β-convergence” in “growth regressions.” It means that output per worker in each country converges to productivity but does not imply convergence across countries, since productivity tends to diverge from the global frontier. The second contribution is to the literature, which finds that income gaps across countries are due mainly to differential technology adoption. This paper shows that the gaps in technology are not only large but keep growing over time.
Tuning in to the radio environment of HD189733b
Authors: Kavanagh R. D. , Vidotto A. A. , Fionnagáin D. Ó , Bourrier V. , Fares R. , Jardine M. , Helling Ch. , Moutou C. , Llama J. , Wheatley P. J.
Published: September 2020

The hot Jupiter HD189733b is expected to be a source of strong radio emission, due to its close proximity to its magnetically active host star. Here, we model the stellar wind of its host star, based on reconstructed surface stellar magnetic field maps. We use the local stellar wind properties at the planetary orbit obtained from our models to compute the expected radio emission from the planet. Our findings show that the planet emits with a peak flux density within the detection capabilities of LOFAR. However, due to absorption by the stellar wind itself, this emission may be attenuated significantly. We show that the best time to observe the system is when the planet is near primary transit of the host star, as the attenuation from the stellar wind is lowest in this region.
A large rotating structure around AB Doradus A at VLBI scale
Authors: Climent J. B. , Guirado J. C. , Azulay R. , Marcaide J. M.
Published: September 2020

We report the results of three VLBI observations of the pre-main-sequence star AB Doradus A at 8.4 GHz. With almost three years between consecutive observations, we found a complex structure at the expected position of this star for all epochs. Maps at epochs 2007 and 2010 show a double core-halo morphology while the 2013 map reveals three emission peaks with separations between 5 and 18 stellar radii. Furthermore, all maps show a clear variation of the source structure within the observing time. We consider a number of hypothesis in order to explain such observations, mainly: magnetic reconnection in loops on the polar cap, a more general loop scenario and a close companion to AB Dor A.
Various scenarios for the equatorward migration of sunspots
Authors: Elstner Detlef , Fournier Yori , Arlt Rainer
Published: September 2020

The profile of the differential rotation together with the sign of the alpha-effect determine the dynamo wave direction. In early models of the solar dynamo the dynamo wave often leads to a poleward migration of the activity belts. Flux transport by the meridional flow or the effect of the surface shear layer are possible solutions. In a model including the corona, we show that various migrations can be obtained by varying the properties of the corona. A new dynamo of Babcock-Leighton type also leads to the correct equatorward migration by the non-linear relation between flux density and rise time of the flux.
Influence of the magnetic field of stellar wind on hot jupiter’s envelopes
Authors: Bisikalo Dmitry V. , Zhilkin Andrey G.
Published: September 2020

Hot Jupiters have extended gaseous (ionospheric) envelopes, which extend far beyond the Roche lobe. The envelopes are loosely bound to the planet and, therefore, are strongly influenced by fluctuations of the stellar wind. We show that, since hot Jupiters are close to the parent stars, magnetic field of the stellar wind is an important factor defining the structure of their magnetospheres. For a typical hot Jupiter, velocity of the stellar wind plasma flow around the atmosphere is close to the Alfvén velocity. As a result stellar wind fluctuations, such as coronal mass ejections, can affect the conditions for the formation of a bow shock around a hot Jupiter. This effect can affect observational manifestations of hot Jupiters.
Discovering the atmospheres of hot Jupiters
Authors: Cauley P. Wilson
Published: September 2020

Hot Jupiters are an extraordinary class of exoplanets, orbiting their host stars with periods of hours to a few days. Some of these objects have day-side temperatures approaching photospheric temperatures of late K-type stars. I will give an overview of how we characterize the atmospheres of these fascinating objects and some the more recent exciting results to come from ground and space-based telescopes, as well as what the future holds for detailed characterization of short-period exoplanet atmospheres.
Probing solar-cycle variations of magnetic fields in the convection zone using meridional flows
Authors: Lin Chia-Hsien , Chou Dean-Yi
Published: September 2020

Solar magnetic fields are believed to originate from the base of convection zone. However, it has been difficult to obtain convincing observational evidence of the magnetic fields in the deep convection zone. The goal of this study is to investigate whether solar meridional flows can be used to detect the magnetic-field effects. Meridional flows are axisymmetric flows on the meridional plane. Our result shows that the flow pattern in the entire convection zone changes significantly from solar minimum to maximum. The changes all centered around active latitudes, suggesting that the magnetic fields are responsible for the changes. The results indicate that the meridional flow can be used to detect the effects of magnetic field in the deep convection zone.

The results have been published in the Astrophysical Journal (lc2018).
3D Modeling of the Structure and Dynamics of a Main-Sequence F-type Star
Authors: Kitiashvili Irina N. , Wray Alan A.
Published: September 2020

Current state-of-the-art computational modeling makes it possible to build realistic models of stellar convection zones and atmospheres that take into account chemical composition, radiative effects, ionization, and turbulence. The standard 1D mixing-length-based evolutionary models are not able to capture many physical processes of the stellar interior dynamics. Mixing-length models provide an initial approximation of stellar structure that can be used to initialize 3D radiative hydrodynamics simulations which include realistic modeling of turbulence, radiation, and other phenomena.

In this paper, we present 3D radiative hydrodynamic simulations of an F-type main-sequence star with 1.47 solar mass. The computational domain includes the upper layers of the radiation zone, the entire convection zone, and the photosphere. The effects of stellar rotation is modeled in the f-plane approximation. These simulations provide new insight into the properties of the convective overshoot region, the dynamics of the near-surface, highly turbulent layer, and the structure and dynamics of granulation. They reveal solar-type differential rotation and latitudinal dependence of the tachocline location.
Observational constraints for solar-type Stellar winds
Authors: Güdel Manuel
Published: September 2020

Ionized winds from late-type main-sequence stars are important for stellar spin-down and therefore the evolution of stellar activity; winds blow an “astrosphere” into the interstellar medium that absorbs a large part of galactic cosmic rays; and the winds play a key role in shaping planetary environments, in particular their upper atmospheres. These issues have been well studied for the solar wind but little is known about winds escaping from other solar-type stars. Several methods have been devised to either detect winds directly or to infer the presence of such winds from features that are shaped by the winds. This paper summarizes these methods and discusses exemplary findings. There is need for more studies using multiple methods for the same stars.
A peripatetic model for teaching Latin
Authors: Harvey Clare
Published: September 2020

This article explores a model of teaching Latin at several state-funded secondary schools within the same geographical location. This model could work for Latin teachers who wish to reintroduce Latin to parts of the country where there are few ready-made jobs in Classics teaching. It will work best in an area where there are a number of secondary schools within easy travelling distance of one another.
Teacher Trainees Telling Tales
Authors: Hunt Steven , Morrice Anya , Knox Daisy , Malik Iaomie , Hawkesworth Jordan , Barker Eleanor , Mahon Clare , Ubhi Jaspal , Molteni Giorgio , Hambly Rachel , Ruczynska Aleksandra , McNally Lawrence , Connor Benjamin
Published: September 2020

Trainees were encouraged to tell a mythological story to the class, lasting about ten minutes. They could use props and other visual aids if they wished, but the emphasis was for them to practise speaking before the class, using prompt cards if necessary, and employing all the techniques of a professional oral ‘poet’ – such as gesture, eye contact, tone of voice and so on. There is obviously considerable general interest among younger students about mythology. Locally, interest is captured by the Cambridge School Classics project which puts on an annual Ovid Mythology competition and the website War with Troy is used by several of the schools where trainees are placed. Its use as a stimulus for learning has been well-documented by its author and past PGCE subject lecturer Bob Lister (2005, 2007) and by Walker (2018), a former teacher trainee from the faculty. Some of the Latin textbooks such as Minimus (Bell, 1999) and Suburani (Hands-Up Education, 2020) contain myth episodes and are familiar to the teacher trainees. The GCSE and A Level qualifications often contain mythological subject matter. Khan-Evans (2018) has shown how older students of Classics have retained deep-rooted affection for mythological stories in their earlier schooldays. Research into the power of mythological storytelling as a stimulus for learning, creative arts and even therapy is current, as the Our Mythical Childhood project (2020) has demonstrated. A book of the project's work is eagerly anticipated next year. The recent Troy exhibition at the British Museum has also awoken considerable interest.
Assimilation of the Rain Gauge Measurements Using Particle Filter
Authors: Kumar Prashant
Published: September 2020

The well‐recognized constraint of nonlinear and non‐Gaussian distribution of rainfall observation limits its assimilation in the high‐dimensional numerical weather prediction (NWP) model. In this study, rainfall observed from Indian Meteorological Department (IMD) rain gauges over Indian landmass is assimilated in the Weather Research and Forecasting (WRF) model using particle filter. In the framework of imperfect weather models, particles (or ensembles) for rainfall predictions are created with various combinations of model physics (viz., cumulus parameterization, microphysics and planetary boundary layer schemes). The multiple hypotheses are used to determine the weights for different particles, and this is the step where IMD rainfall data are used for assimilation. Further, a resampling step is performed to generate new particles from high weight particles using stochastic kinetic‐energy backscatter scheme (SKEBS) method in which dynamical variables are perturbed into the model physics. Results, based on rainfall verification scores, suggest that the assimilation of the rainfall using particle filter could improve the prediction of rainfall over CNT runs (unweighted particles; without assimilation). Moreover, surface and vertical profile of temperature, water vapor mixing ratio (WVMR), and wind speed are also improved in 24‐hr forecasts.
CRISPR/Cas9 genome-wide loss-of-function screening identifies druggable cellular factors involved in sunitinib resistance in renal cell carcinoma
Authors: Makhov Peter , Sohn Ji A. , Serebriiskii Ilya G. , Fazliyeva Rushaniya , Khazak Vladimir , Boumber Yanis , Uzzo Robert G. , Kolenko Vladimir M.
Published: September 2020

Background

Multi-targeted tyrosine kinase inhibitors (TKIs) are the standard of care for patients with advanced clear cell renal cell carcinoma (ccRCC). However, a significant number of ccRCC patients are primarily refractory to targeted therapeutics, showing neither disease stabilisation nor clinical benefits.

Methods

We used CRISPR/Cas9-based high-throughput loss of function (LOF) screening to identify cellular factors involved in the resistance to sunitinib. Next, we validated druggable molecular factors that are synthetically lethal with sunitinib treatment using cell and animal models of ccRCC.

Results

Our screening identified farnesyltransferase among the top hits contributing to sunitinib resistance in ccRCC. Combined treatment with farnesyltransferase inhibitor lonafarnib potently augmented the anti-tumour efficacy of sunitinib both in vitro and in vivo.

Conclusion

CRISPR/Cas9 LOF screening presents a promising approach to identify and target cellular factors involved in the resistance to anti-cancer therapeutics.
NAA10 p.(N101K) disrupts N-terminal acetyltransferase complex NatA and is associated with developmental delay and hemihypertrophy
Authors: McTiernan Nina , Gill Harinder , Prada Carlos E. , Pachajoa Harry , Lores Juliana ,   CAUSES study, Arnesen Thomas
Published: September 2020

Nearly half of all human proteins are acetylated at their N-termini by the NatA N-terminal acetyltransferase complex. NAA10 is evolutionarily conserved as the catalytic subunit of NatA in complex with NAA15, but may also have NatA-independent functions. Several NAA10 variants are associated with genetic disorders. The phenotypic spectrum includes developmental delay, intellectual disability, and cardiac abnormalities. Here, we have identified the previously undescribed NAA10 c.303C>A and c.303C>G p.(N101K) variants in two unrelated girls. These girls have developmental delay, but they both also display hemihypertrophy a feature normally not observed or registered among these cases. Functional studies revealed that NAA10 p.(N101K) is completely impaired in its ability to bind NAA15 and to form an enzymatically active NatA complex. In contrast, the integrity of NAA10 p.(N101K) as a monomeric acetyltransferase is intact. Thus, this NAA10 variant may represent the best example of the impact of NatA mediated N-terminal acetylation, isolated from other potential NAA10-mediated cellular functions and may provide important insights into the phenotypes observed in individuals expressing pathogenic NAA10 variants.
Mean amplitude of intraocular pressure excursions: a new assessment parameter for 24-h pressure fluctuations in glaucoma patients
Authors: Zhai Ruyi , Cheng Jingyi , Xu Huan , Fang Zhaobin , Chen Xu , Qiu Siyu , Sun Xinghuai , Lee Richard K. , Xiao Ming , Kong Xiangmei
Published: September 2020

Background

Intraocular pressure (IOP) is important in the pathogenesis of glaucoma and its circadian fluctuations are important in the disease management; however, there are no adequate parameters to describe the fluctuations. This study investigates a new parameter, mean amplitude of intraocular pressure excursion (MAPE), and compares its ability in assessing 24-h IOP fluctuations with other ocular parameters.

Methods

Only the right eye was evaluated in each of the 79 healthy people and 164 untreated patients with primary open angle glaucoma (POAG). Each participant underwent 24-h IOP monitoring by measuring IOP every 2 h. IOP fluctuations were expressed as MAPE calculations and currently used parameters included mean IOP, standard deviation of IOP, max difference and area under the circadian IOP curve. Comprehensive ophthalmologic examinations were also performed. Associations between visual field deficits and IOP fluctuation parameters were investigated via partial least squares (PLS) regression. Diagnostic performance was evaluated with area under the receiver operating characteristic curves (ROC).

Results

Compared with healthy volunteers, the MAPE values in POAG patients were higher (4.16 ± 1.90 versus 2.45 ± 0.89, p < 0.01). In PLS regressions where visual field deficits were as dependent variable, MAPE had the highest score regarding variable importance in projection, and its standard regression coefficient was larger than other parameters. Diagnostic performance analysis showed the area under ROC of MAPE for glaucoma detection was 0.822 (0.768–0.868, p < 0.001).

Conclusions

MAPE might be an effective parameter in clinic to characterise IOP circadian fluctuations.
The stability of envelope-pseudotyped lentiviral vectors
Authors: Dautzenberg Iris J. C. , Rabelink Martijn J. W. E. , Hoeben Rob C.
Published: September 2020

Lentiviral vectors have become popular tools for stable genetic modification of mammalian cells. In some applications of lentiviral vector-transduced cells, infectious-lentiviral particles should be absent. Quantification of the free-vector particles that remain from the inoculum can be difficult. Therefore a formula was established that yields an estimation of the ‘Reduction Ratio.’ This ratio represents the loss of titer based on a number of vector-inactivating effects. In this study, we evaluated several parameters and assumptions that were used in the current formula. We generated new data on the stability and trypsin sensitivity of lentiviral vectors pseudotyped with eight heterologous envelope proteins and the loss of vectors by washing or passaging the cell cultures. Our data demonstrate that the loss of virus titer under the influence of trypsin as well as the half-life of the particles in tissue culture medium is dependent on the vector’s envelope protein. While VSV-G-envelope-pseudotyped particles were unsensitive to trypsin, the titer of vectors pseudotyped with other envelope proteins decreased 2–110-fold. The half-life in culture medium ranged from 8 to 40 h for the different envelope-pseudotyped vectors, with 35 h for VSV-G-envelope-pseudotyped vector particles. Additionally, we found that removal of the culture medium from Ø35 mm to Ø10 cm dishes reduces the amount of vector particles in the culture by 50-fold and 20-fold, respectively. Together these data can be used to more precisely estimate the maximum number of free lentiviral vector particles in cell cultures.
Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis
Authors: Bogdanow Boris , Schmidt Max , Weisbach Henry , Gruska Iris , Vetter Barbara , Imami Koshi , Ostermann Eleonore , Brune Wolfram , Selbach Matthias , Hagemeier Christian , Wiebusch Lüder
Published: September 2020

Herpesviruses encode conserved protein kinases (CHPKs) to stimulate phosphorylation-sensitive processes during infection. How CHPKs bind to cellular factors and how this impacts their regulatory functions is poorly understood. Here, we use quantitative proteomics to determine cellular interaction partners of human herpesvirus (HHV) CHPKs. We find that CHPKs can target key regulators of transcription and replication. The interaction with Cyclin A and associated factors is identified as a signature of β-herpesvirus kinases. Cyclin A is recruited via RXL motifs that overlap with nuclear localization signals (NLS) in the non-catalytic N termini. This architecture is conserved in HHV6, HHV7 and rodent cytomegaloviruses. Cyclin A binding competes with NLS function, enabling dynamic changes in CHPK localization and substrate phosphorylation. The cytomegalovirus kinase M97 sequesters Cyclin A in the cytosol, which is essential for viral inhibition of cellular replication. Our data highlight a fine-tuned and physiologically important interplay between a cellular cyclin and viral kinases.
A possible universal role for mRNA secondary structure in bacterial translation revealed using a synthetic operon
Authors: Chemla Yonatan , Peeri Michael , Heltberg Mathias Luidor , Eichler Jerry , Jensen Mogens Høgh , Tuller Tamir , Alfonta Lital
Published: September 2020

In bacteria, translation re-initiation is crucial for synthesizing proteins encoded by genes that are organized into operons. The mechanisms regulating translation re-initiation remain, however, poorly understood. We now describe the ribosome termination structure (RTS), a conserved and stable mRNA secondary structure localized immediately downstream of stop codons, and provide experimental evidence for its role in governing re-initiation efficiency in a synthetic Escherichia coli operon. We further report that RTSs are abundant, being associated with 18%–65% of genes in 128 analyzed bacterial genomes representing all phyla, and are selectively depleted when translation re-initiation is advantageous yet selectively enriched so as to insulate translation when re-initiation is deleterious. Our results support a potentially universal role for the RTS in controlling translation termination-insulation and re-initiation across bacteria.