bluuebunny/crossref_metadata_2025 huggingface dataset:
Isolated Luxatio Erecta Femoris – Case Series and Review of Literature
Authors: Kumar A S Arun , George Jiju , Nair Ayyappan
Published: July 2022

Introduction: Luxatio erecta femoris or inferior hip dislocation is the rarest type of hip dislocation. It can be caused by a severe trauma to the hip and the mechanism of injury is often very complex. Very few cases have been reported in the literature, and often associated with other musculoskeletal injuries. Overall about 3026 cases were reported till recently. Case Presentations:We came across five cases of Luxatio erecta femoris from our six year study period from 2015 to 2020. All five cases were males (mean age-28.4 years, age range 20–40 years). All of them were isolated injuries (pure dislocation without any associated femur, acetabular, or pelvic fractures). We will present the details of these cases along with review of literature, trying to unravel the mechanism of such an injuries. Conclusion:With the increase in high energy road traffic accidents, the incidence of luxatio erecta femoris in adults has increased. We could identify all those injuries and treated it with excellent clinical outcome. This type of rare dislocations if properly identified, we can manage it without much delay and very minimal complications. Keywords:Luxatio erecta femoris, dislocation, trauma.
Expansión Urbana de La Habana: El Cerro 1925–1960
Authors: Jesús Rouco Méndez Alexis , Muñoz Hernández Ruslan
Published: July 2022

Urban Expansion of Havana: El Cerro 1925–1960

As part of the valuable urban history of Havana in the 20th century, the territory of El Cerro treasures a mixed urban fabric, with developments and layouts from different historical periods. With the advance of the century, it progressively extended its paths beyond its historic nucleus, with urbanisations of diverse character that welcomed from proletarian groups to small merchants and a thriving middle class of professionals. However, these areas have not been sufficiently studied, so their values ​​are unknown and increase their vulnerability to inappropriate actions that endanger their identity. The research set out to document this urban development experienced between 1925 and 1960 from the analysis of archival documentary sources supplemented with fieldwork. The results show a wide and diverse universe of urban networks that left an important mark on the expansion and consolidation of the city, as part of Cuban cultural history.
Cuban Emigration to the United States, Part II, from 1990 to 2019: A Statistical and Comparative Analysis
Authors: Lamrani Salim
Published: July 2022

Since 1959, Cuban emigration seems to have been the subject of two consensuses. First, the Cuban Revolution would have resulted in a significant migratory movement towards the United States. Second, that this would reflect the rejection of the process of social transformation structured around a one-party political system put in place by Fidel Castro. The migration statistics of the US authorities, available for the period from 1860 to 2019, will shed light on this question by comparing the various flows from Cuba at different times (1860–1959, 1960–89, 1990–2019). Likewise, a comparative analysis of migratory flows emitted by the countries of the region will assess the relevance of these two hypotheses.
Biocompatible spider silk-based metal-dielectric fiber optic sugar sensor
Authors: E Hsuan-Pei , Kong Jelene Antonicole Ngan , Chen Wei-Chun , Chen Che-Chin , Cheng Chia-Hsiung , Liu Cheng-Yang
Published: July 2022

Various optical components employed in biomedical applications have been fabricated using spider silk because of its superior properties, such as elasticity, tensile strength, biodegradability, and biocompatibility. In this study, a highly sensitive fiber optic sugar sensor is fabricated using metal-nanolayer-coated spider silk. The spider silk, which is directly collected from Nephila pilipes, a giant wood spider, is naturally a protein-based biopolymer with great flexibility, low attenuation, and easy functionalization. The surface of the spider silk-based fiber is coated with a metal nano-layer by using the glancing angle deposition technique. This fiber optic sugar sensor is based on the principle of the change in the refractive indices of sugar solutions. The attained experimental results show that the proposed sugar sensor is highly sensitive in the detection of fructose, sucrose, and glucose concentrations. This work may provide a new way to realize precise and sensitive online sugar measurements for point-of-care diagnostics.
Hyperfine structure and absolute frequency of 127I2 transitions at 514  nm for wavelength standards at 1542  nm
Authors: Ikeda Kohei , Kobayashi Takumi , Yoshiki Mayuko , Akamatsu Daisuke , Hong Feng-Lei
Published: July 2022

The hyperfine structures of the P(57)45-0, P(91)48-0, and R(73)46-0 lines of molecular iodine (

127

I

2

) at 514 nm were studied using third-harmonic generation of a 1542 nm external-cavity diode laser and Doppler-free spectroscopy. The frequencies of the 1542 nm diode laser locked to the hyperfine transitions of these iodine lines are close to those of the P(16) transition in the

ν
1

+

ν
3

band of acetylene (

13

C

2

H

2

), which is used as a wavelength standard for telecom applications. The absolute frequencies of the observed 59 iodine hyperfine transitions were determined with an uncertainty of 5.4 kHz (fractional uncertainty of

9.3

×

10

−
12

). Highly accurate hyperfine constants were obtained through fitting of the measured hyperfine splittings to a four-term Hamiltonian that includes electric quadrupole, spin–rotation, tensor spin–spin, and scalar spin–spin interactions with an uncertainty of a few kHz. The observed hyperfine transitions provide wavelength standards for telecom applications with various optical frequencies and reduced uncertainties compared with the acetylene wavelength standard.
Impact of homodyne receiver bandwidth and signal modulation patterns on the continuous-variable quantum key distribution
Authors: Liu Jianqiang , Cao Yanxia , Wang Pu , Liu Shuaishuai , Lu Zhenguo , Wang Xuyang , Li Yongmin
Published: July 2022

In continuous-variable quantum key distribution (CV-QKD), the key information are encoded on quadratures of the optical field, which are measured via balanced homodyne detector (BHD). The bandwidth of the BHD is one of key parameters for precise characterization of quantum states. We establish a theoretical model to analyze the impact of the BHD bandwidth and signal modulation patterns on the channel parameters estimation of CV-QKD systems. Based on the proposed model, the secure key rate of a practical CV-QKD system under different BHD bandwidths and signal modulation patterns are investigated. Our results show that insufficient BHD bandwidth will result in wrong estimate of the transmission loss and excess noise, which significantly affects the performance of CV-QKD systems. Given the BHD bandwidth, there exists an optimal signal repetition rate that maximizes the secure key rate. The BHD bandwidth requirement of the QKD system increases with the transmission distance for large duty cycle pulse. Furthermore, the root raised-cosine pulse signal modulation performs better than the square pulse signal modulation in general.
Broadband transparent and high-Q resonant polarization meta-grating enabled by a non-local geometric-phase metasurface
Authors: Sang Di , Xu Mingfeng , An Qiang , Fu Yunqi
Published: July 2022

Spatial wavefront control and high-Q spectral filtering are both of great importance for various optical applications, such as eye-tracking for eyewear, planar optical modulators, and optical sensing. However, it is a great challenge to simultaneously satisfy these two functionalities in a metasurface due to the inevitable conflicts of local and non-local modes, where local modes of a single meta-atom manipulate the wavefront in a broadband range, while non-local collective modes of extended meta-atoms only support high-Q resonances at certain characteristic wavelengths. Here, we demonstrate a low-contrast dielectric non-local meta-grating that provides both spatial and spectral control of light in a broadband range of 700-1600 nm, offering elaborate wavefront shaping only for narrow-band resonances. Such counterintuitive functionality is supported by spatially tailored dark modes (quasi-bound states in the continuum) encoding with spatially varying geometric phases, while low-contrast dielectric provides broadband non-resonant transmission. Moreover, a broadband transparent polarization meta-grating with two resonance wavelengths is presented. Non-local geometric-phase metasurfaces open an exciting avenue for wavefront shaping and spectral manipulation, and may have potential applications in sensing, lasing, and spectral filtering.
Hybrid method for monitoring large Fabry-Pérot cavity displacements with nanometer precision
Authors: Sweeney Daniel C. , Birri Anthony , Petrie Christian M.
Published: July 2022

The change in length of an optical fiber-based Fabry-Pérot cavity (FPC) can be precisely measured using phase tracking, but the displacement range is limited by phase ambiguity. Period tracking techniques determine the absolute FPC length, but with larger uncertainties from tracking the spacing between multiple peaks. A hybrid method is demonstrated that identifies appropriate peaks for phase tracking using a coarse estimate obtained from the free spectral range to effectively maintain the high precision (∼1 nm) of phase tracking techniques to measure ∼24 µm displacements, well beyond the range limitations (typically <1 µm) of phase tracking methods.
B-spline surface based 3D reconstruction method for deflectometry
Authors: Liu Cheng , Gao Nan , Meng Zhaozong , Zhang ZongHua , Gao Feng , Jiang Xiangqian
Published: July 2022

In the field of optical three-dimension (3-D) measurement, reconstruction usually is completed by the integration of a two-dimensional (2-D) gradient data set. Position and posture of camera and shape of the surface under test determine the location of gradient data which usually is on quadrilateral grids. This paper proposes a B-spline surface-based 3D reconstruction method for deflectometry, which reconstructs the surface under test with its 2-D gradient data set. The 2-D gradient data set consists of gradient data and the 2-D location of the gradient data in the camera coordinate system. The 2-D gradient data set is first transferred to the cameras’ virtual image plane, so it locates on rectangular grids. Then, based on the properties of the B-spline basis function and characteristics of the camera, linear equations are derived to solve control points along the virtual image plane. The solved control points reconstruct the surface under test in the camera coordinate system. The property of the B-spline basis function determines the relationship between the depth of the surface and its derivative. The characteristic of the camera determines the relationship between the depth of the surface and the 2-D location of the gradient data. Meanwhile, the accuracy of the 2-D location can also be improved by the linear equations. Finally, simulated and actual experiments show that the proposed method is accurate and efficient at reconstructing surfaces in deflectometry.
Silicon photonic flat-top WDM (de)multiplexer based on cascaded Mach-Zehnder interferometers for the 2 µm wavelength band
Authors: Yi Qiyuan , Zheng Shuang , Yan Zhiwei , Cheng Guanglian , Xu Fanglu , Li Qiyuan , Shen Li
Published: July 2022

The 2 µm wavelength band has proven to be a promising candidate for the next communication window. Wavelength-division multiplexing (WDM) transmission at 2 µm can greatly increase the capacity of optical communication systems. Here, we experimentally demonstrate a high-performance silicon photonic flat-top 8-channel WDM (de)multiplexer based on cascaded Mach-Zehnder interferometers for the 2 µm wavelength band. A three-stage-coupler scheme is utilized to provide passbands and reduce channel crosstalk, and 11 thermo-optic phase shifters have allowed active compensation of waveguide phase errors. The fabricated device shows low insertion loss (< 0.9 dB), channel crosstalk (< 20.6 dB) and 1-dB bandwidth of 2.3 nm for operating wavelength ranging from 1955nm to 1985nm. The demonstrated (de)multiplexer could potentially be used for WDM optical data communication in the 2 µm spectral band.
GaInSn liquid nanospheres as a saturable absorber for Q-switched pulse generation at 639 nm
Authors: Chen Bo , Wang Peifu , Zhang Ning , Li Kuan , Zhang Ke , Liu Shande , Xu Jinlong , Sun Zhipei
Published: July 2022

Liquid metals, which possess the superiority of low cost, shape-reconfigurability, and excellent optoelectronic properties, have been applied in various fields, such as flexible electronics, superconductivity, and coolants. In this paper, high-quality GaInSn liquid nanospheres synthesized by the ultrasonic method are applied for nonlinear optics and laser switches. The saturation absorption property derived from localized surface plasmon resonance at 639 nm is studied based on the open-aperture Z-scan technique, exhibiting a modulation depth of ∼35.5% and a saturation fluence of ∼21.75 mJ/cm2, respectively. The as-prepared GaInSn liquid nanospheres are also successfully utilized as a saturable absorber to achieve a stable Q-switched Pr:YLF laser at 639 nm. The output pulse width can reach ∼280 ns with a pulse repetition rate of ∼174.8 kHz. Our results suggest that GaInSn liquid nanospheres are a candidate material for generating visible laser pulses, which is of great interest for potential applications in visible nonlinear optics.
Increased Colocalization and Interaction Between Decidual Protein Kinase A and Insulin-like Growth Factor–Binding Protein-1 in Intrauterine Growth Restriction
Authors: Gupta Madhulika B. , Biggar Kyle K. , Li Cun , Nathanielsz Peter W. , Jansson Thomas
Published: July 2022

Increased phosphorylation of decidual insulin-like growth factor–binding protein-1 (IGFBP-1) can contribute to intrauterine growth restriction (IUGR) by decreasing the bioavailability of insulin-like growth factor-1 (IGF-1). However, the molecular mechanisms regulating IGFBP-1 phosphorylation at the maternal–fetal interface are poorly understood. Protein kinase A (PKA) is required for normal decidualization. Consensus sequences for PKA are present in IGFBP-1. We hypothesized that the expression/interaction of PKA with decidual IGFBP-1 is increased in IUGR. Parallel reaction monitoring-mass spectrometry (PRM-MS) identified multiple PKA peptides ( n=>30) co-immunoprecipitating with IGFBP-1 in decidualized primary human endometrial stromal cells (HESC). PRM-MS also detected active PKApThr197 and greater site-specific IGFBP-1 phosphorylation(pSer119), (pSer98+pSer101) (pSer169+pSer174) in response to hypoxia. Hypoxia promoted colocalization [dual immunofluorescence (IF)] of PKA with IGFBP-1 in decidualized HESC. Colocalization (IF) and interaction (proximity ligation assay) of PKA and IGFBP-1 were increased in decidua collected from placenta of human IUGR pregnancies ( n=8) compared with decidua from pregnancies with normal fetal growth. Similar changes were detected in decidual PKA/IGFBP-1 using placenta from baboons subjected to maternal nutrient reduction (MNR) vs controls ( n=3 each). In baboons, these effects were evident in MNR at gestational day 120 prior to IUGR onset. Increased PKA-mediated phosphorylation of decidual IGFBP-1 may contribute to decreased IGF-1 bioavailability in the maternal–fetal interface in IUGR.
Role of actin filaments and cis binding in cadherin clustering and patterning
Authors: Yu Qilin , Kim Taeyoon , Rajagopal Vijay
Published: July 2022

Cadherins build up clusters to maintain intercellular contact through trans and cis (lateral) bindings. Meanwhile, interactions between cadherin and the actin cytoskeleton through cadherin/F-actin linkers can affect cadherin dynamics by corralling and tethering cadherin molecules locally. Despite many experimental studies, a quantitative, mechanistic understanding of how cadherin and actin cytoskeleton interactions regulate cadherin clustering does not exist. To address this gap in knowledge, we developed a coarse-grained computational model of cadherin dynamics and their interaction with the actin cortex underlying the cell membrane. Our simulation predictions suggest that weak cis binding affinity between cadherin molecules can facilitate large cluster formation. We also found that cadherin movement inhibition by actin corralling is dependent on the concentration and length of actin filaments. This results in changes in cadherin clustering behaviors, as reflected by differences in cluster size and distribution as well as cadherin monomer trajectory. Strong cadherin/actin binding can enhance trans and cis interactions as well as cadherin clustering. By contrast, with weak cadherin/actin binding affinity, a competition between cadherin-actin binding and cis binding for a limited cadherin pool leads to temporary and unstable cadherin clusters.
Calculating worldwide needs for morphine for pain in advanced cancer and proportions feasibly met by country estimates of requirements and consumption. Retrospective, time-series analysis (1997–2017)
Authors: Clark Joseph , Crowther Lucia , Johnson Miriam J. , Ramsenthaler Christina , Currow David C.
Published: July 2022

Lack of access to therapeutic opioids continuing causes global health inequalities. Access to morphine for symptom control is regulated under the terms of the Single Convention on Narcotics, countries must submit annual morphine requirement estimates and report consumption to the International Narcotics Control Board (INCB). INCB indicates access to morphine is increasing, however, estimated needs are unreported so changing proportions of needs feasibly met by requirements and consumption are unknown. Retrospective time series-analysis taking cross-sections every five years of gaps between calculated needs for morphine for people who die from cancer and total treatable using estimates of requirements and consumption (1997, 2002, 2007, 2012, 2017). We calculated need using INCB-recommended methods (80% of people who die from cancer require 67.5mg of morphine daily for 90 days (6.075g)) for countries reporting estimates and consumption using Global Burden of Disease cancer deaths by country. Gaps between calculated need and total treatable population using estimates and consumption were calculated. We report proportions of need feasibly met by estimates and consumption for included countries, by World Bank Income group. Global availability of morphine increased, from estimates sufficient to treat 86% of calculated needs in 1997, to 701% in 2017. However, proportion of countries estimating requirements feasibly meeting >100% of calculated needs rose only from 16% to 30%. Almost all Low-and-Middle-Income Countries submitted inadequate estimates with little change in 20 years. Consumption was lower than calculated needs at all time-points. Very few countries reported consumption greater than their estimate of requirement. Most countries submitted morphine estimates insufficient to meet analgesic needs of people who died from cancer. Estimates of requirements contextualise future Consumption, and increases in adequacy of estimates and consumption were minimal over 20 years. Annual publication of calculated morphine needs alongside estimates and consumption may be a key step to drive countries’ accountabilities.
Health system bottlenecks hindering provision of supportive and dignified maternity care in public health facilities
Authors: Hameed Waqas , Khan Bushra , Siddiqi Sameen , Asim Muhammad , Avan Bilal Iqbal
Published: July 2022

Mistreatment with women during childbirth is prevalent in many in low- and middle-income countries. There is dearth of evidence that informs development of health system interventions to promote supportive and respectful maternity care in facility-based settings. We examined health systems bottlenecks that impedes provision of supportive and respectful maternity care in secondary-level public healthcare system of Pakistan. Using a qualitative exploratory design, forty in-depth interviews conducted with maternity care staff of six public health facilities in southern Pakistan. Development of interview guide and data analyses were guided by the WHO’s six health system building blocks. A combination of inductive and deductive approach was used for data analyses. Our study identified range of bottlenecks impeding provision of RMC. In terms of leadership/governance, there was lack of institutional guidelines, supervision and monitoring, and patient feedback mechanism. No systematic mechanism existed to screen and record patient psychosocial needs. Health workforce lacked training opportunities on RMC that resulted in limited knowledge and skills; there were also concerns about lack of recognition from leadership for good performers, and poor relationship and coordination between clinical and non-clinical staff. Regarding the domain of service delivery, we found that patients were perceived as un-cooperative, non-RMC manifestations were acceptable and normalized under certain conditions, and restrictive policies for active engagement of companions. Finally, lack of cleanliness, curtains for privacy, seating arrangement for companion were the identified issues infrastructural issues. A service-delivery intervention package is needed that effectively uses all six components of the health system: from investments in capacity building of maternity teams to creating a conducive facility environment via proper governance and accountability mechanisms. Such interventions should not only focus on provision of maternity care in a respectful and dignified manner, but also ensure that care is responsive to the psychosocial needs of pregnant women without any discrimination.
High prevalence of Panton-Valentine leukocidin positive, multidrug resistant, Methicillin-resistant Staphylococcus aureus strains circulating among clinical setups in Adamawa and Far North regions of Cameroon
Authors: Mohamadou Mansour , Essama Sarah Riwom , Ngonde Essome Marie Chantal , Akwah Lillian , Nadeem Nudrat , Gonsu Kamga Hortense , Sattar Sadia , Javed Sundus
Published: July 2022

Staphylococcus aureus (S. aureus) is one of the earliest pathogens involved in human infections, responsible for a large variety of pathologies. Methicillin was the first antibiotic used to treat infections due to S. aureus but infections due to Methicillin resistant Staphylococcus aureus (MRSA) originated from hospital settings. Later, severe infections due to MRSA without any contact with the hospital environment or health care workers arose. Prevalence of MRSA has shown an alarming increase worldover including Cameroon. This Cross-sectional study was designed to evaluate the occurrence of MRSA infections in five different, most frequented Hospitals in northern Cameroon. Socio demographic data was recorded through questionnaire and different clinical specimens were collected for bacterial isolation. Identification of S. aureus was confirmed via 16s rRNA amplification using S. aureus specific primers. Molecular characterisation was performed through mecA gene, Luk PV gene screening and SCCmec typing. A total of 380 S. aureus clinical isolates were obtained of which 202 (53.2%) were nonduplicate multidrug resistant isolates containing, 45.5% MRSA. Higher number of MRSA was isolated from pus (30.4%) followed by blood culture (18.5%), and urine (17.4%). Patients aged 15 to 30 years presented high prevalence of MRSA (30.4%). Majority isolates (97.8%) carried the mecA gene, PVL toxin screening indicated 53.3% isolates carried the lukPV gene. Based on PVL detection and clinical history, CA-MRSA represented 53.3% of isolates. SCCmec typing showed that the Type IV was most prevalent (29.3%), followed by type I (23.9%). Amongst MRSA isolates high resistance to penicillin (91.1%), cotrimoxazole (86.7%), tetracycline (72.2%), and ofloxacin (70.0%) was detected. Meanwhile, rifampicin, fusidic acid, lincomycin and minocycline presented high efficacy in bacterial control. This study revealed a high prevalence of MRSA among infections due to S. aureus in Northern Cameroon. All MRSA recorded were multidrug resistant and the prevalence of CA MRSA are subsequently increasing, among population.
Vaccination and variants: Retrospective model for the evolution of Covid-19 in Italy
Authors: Fierro Annalisa , Romano Silvio , Liccardo Antonella
Published: July 2022

The last year of Covid-19 pandemic has been characterized by the continuous chase between the vaccination campaign and the appearance of new variants that puts further obstacles to the possibility of eradicating the virus and returning to normality in a short period. In the present paper we develop a deterministic compartmental model to describe the evolution of the Covid-19 in Italy as a combined effect of vaccination campaign, new variant spreading and mobility restrictions. Particular attention is given to the mechanism of waning immunity, appropriately timed with respect to the effective progress of the vaccination campaign in Italy. We perform a retrospective analysis in order to explore the role that different mechanisms, such as behavioral changes, variation of the population mobility, seasonal variability of the virus infectivity, and spreading of new variants have had in shaping the epidemiological curve. We find that, in the large time window considered, the most relevant mechanism is the seasonal variation in the stability of the virus, followed by the awareness mechanism, that induces individuals to increase/relax self-protective measures when the number of active cases increases/decreases. The appearance of the Delta variant and the mobility variations have had instead only marginal effects. In absence of vaccines the emerging scenario would have been dramatic with a percentage difference in the number of total infections and total deaths, in both cases, larger than fifty per cent. The model also predicts the appearance of a more contagious variant (the Omicron variant) and its becoming dominant in January 2022.
Power output from 12 brands of contemporary LED light-curing units measured using 2 brands of radiometers
Authors: Maucoski Cristiane , Price Richard B. , Arrais Cesar A. , Sullivan Braden
Published: July 2022

Background

Given the increasing use of photo-activated resins in dentistry, dentists and researchers need a user-friendly dental radiometer to measure the power output from dental light-curing units (LCUs).

Objective

Our goal was to measure the accuracy of two brands of dental radiometers in reporting the power (mW) from twelve brands of contemporary LCUs compared to a ‘gold standard’ (GS) reference value obtained from an integrating sphere attached to a fiberoptic spectroradiometer.

Methods

The power output was measured from two units of 12 brands of LCUs, five times on the ‘‘GS” system, five times on two Bluephase Meter II dental radiometers, and five times on two Mini Gig hand-held spectroradiometers. The emission spectrum was also recorded using the ‘GS’ integrating sphere. The power values reported by each meter were subjected to t-tests to compare the two examples of each LCU, and 3-way ANOVA followed by Bonferroni’s post-hoc tests. Regression analyses were also performed to determine the relationship between the data from the hand-held radiometers and the ‘GS’ integrating sphere.

Results

There was a large difference in the power values (mW) and the emission spectra from the 12 brands of LCUs on their standard-settings (p<0.001). Except for one LCU (Dental Spark @ 15.1%), the differences between the two LCUs of the same brand were less than 5.3% when measured using the ‘GS’ integrating sphere. Regression analyses showed a highly significant agreement between the power values reported from the two brands of radiometers and the ‘GS’ integrating sphere (R2 > 98%).

Conclusion

We concluded that the power values reported from both brands of dental radiometers we tested were accurate, provided that the light source did not emit wavelengths of light that were beyond the radiometer’s detection limit.
Intention to comply with solid waste management practices among households in Butajira town, Southern Ethiopia using the theory of planned behavior
Authors: Fikadu Semu Debebe , Sadore Abinet Arega , Agafari Gizachew Beykaso , Agide Feleke Doyore
Published: July 2022

Background

One of the world’s most serious environmental issues is solid waste management. It is critical for researchers to understand the intention to comply with solid waste management. Thus, we aim to determine the intention to comply with solid waste management practice among households in Butajira Town using the Theory of Planned Behavior.

Method

A community-based cross-sectional study was conducted on a sample of 422 households in Butajira from June 1 to June 30, 2020. The constructs and principles of the theory of planned behavior (TPB) were measured. We selected using a systematic sampling method and collected data by using a structured interviewer-administered questionnaire. Data was analyzed using SPSS version 25.0. The predictors of intention to practice solid waste management were identified using a multivariable linear regression model. A P-value of less than 5% was considered to declare a significant association.

Results

The findings demonstrated that intention to practice solid waste management explained 86% of the variance explained by all predictors. The perceived behavioral control construct had the greatest impact on households’ behavioral intentions to comply with solid waste management practice (β = 0.16; CI (0.14, 0.18), followed by attitude (β = 0.15; CI (0.11, 0.21) and subjective norms (β = 0.12; CI (0.06, 0.17).

Conclusion

Our study also found that intention has a substantial influence on the behavior of solid waste management practices. Therefore, there is a need to enhance service utilization for solid waste management and to improve outdoor solid waste dropping behavior through door-to-door collection services by municipality. Furthermore, further longitudinal research should be done through intervention mapping.
“Now, I have my baby so I don’t go anywhere”: A mixed method approach to the ‘everyday’ and young motherhood integrating qualitative interviews and passive digital data from mobile devices
Authors: Hagaman Ashley , Lopez Mercado Damaris , Poudyal Anubhuti , Bemme Dörte , Boone Clare , van Heerden Alastair , Byanjankar Prabin , Man Maharjan Sujen , Thapa Ada , Kohrt Brandon A.
Published: July 2022

The impacts of early pregnancy and young motherhood on everyday life, including interpersonal and individual behavior, are not well-known. Passive digital sensing on mobile technology including smartphones and passive Bluetooth beacons can yield information such as geographic movement, physical activity, and mother-infant proximity to illuminate behavioral patterns of a mother’s everyday in Nepal. We contribute to mixed-methods research by triangulating passive sensing data (GPS, accelerometry, Bluetooth proximity) with multiple forms of qualitative data to characterize behavioral patterns and experiences of young motherhood in the first year postpartum. We triangulated this digital information in a constant comparative analysis with in-depth interviews, daily diaries, and fieldnotes. We reveal typical behavioral patterns of rural young mothers and highlight opportunities for integrating this information to improve health and well-being.
Associations of metabolic syndrome and metabolically unhealthy obesity with cancer mortality: The Japan Multi-Institutional Collaborative Cohort (J-MICC) study
Authors: Nguyen Tien Van , Arisawa Kokichi , Katsuura-Kamano Sakurako , Ishizu Masashi , Nagayoshi Mako , Okada Rieko , Hishida Asahi , Tamura Takashi , Hara Megumi , Tanaka Keitaro , Nishimoto Daisaku , Shibuya Keiichi , Koyama Teruhide , Watanabe Isao , Suzuki Sadao , Nishiyama Takeshi , Kuriki Kiyonori , Nakamura Yasuyuki , Saito Yoshino , Ikezaki Hiroaki , Otonari Jun , N. Koyanagi Yuriko , Matsuo Keitaro , Mikami Haruo , Kusakabe Miho , Takeuchi Kenji , Wakai Kenji
Published: July 2022

Purpose

The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. The purpose of this study was to examine the associations of MetS and metabolically unhealthy obesity (MUHO) with cancer mortality in a Japanese population.

Methods

We used data from the Japan Multi-Institutional Collaborative Cohort Study. The study population consisted of 28,554 eligible subjects (14,103 men and 14,451 women) aged 35–69 years. MetS was diagnosed based on the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the Japan Society for the Study of Obesity (JASSO), using the body mass index instead of waist circumference. The Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for total cancer mortality in relation to MetS and its components. Additionally, the associations of obesity and the metabolic health status with cancer mortality were examined.

Results

During an average 6.9-year follow-up, there were 192 deaths from cancer. The presence of MetS was significantly correlated with increased total cancer mortality when the JASSO criteria were used (HR = 1.51, 95% CI 1.04–2.21), but not when the NCEP-ATP III criteria were used (HR = 1.09, 95% CI 0.78–1.53). Metabolic risk factors, elevated fasting blood glucose, and MUHO were positively associated with cancer mortality (P <0.05).

Conclusion

MetS diagnosed using the JASSO criteria and MUHO were associated with an increased risk of total cancer mortality in the Japanese population.
Assessment of left atrial fibrosis progression in canines following rapid ventricular pacing using 3D late gadolinium enhanced CMR images
Authors: Farrag Nadia A. , Thornhill Rebecca E. , Prato Frank S. , Skanes Allan C. , Sullivan Rebecca , Sebben David , Butler John , Sykes Jane , Wilk Benjamin , Ukwatta Eranga
Published: July 2022

Background

Atrial fibrillation (AF) is associated with extracellular matrix (ECM) remodelling and often coexists with myocardial fibrosis (MF); however, the causality of these conditions is not well established.

Objective

We aim to corroborate AF to MF causality by quantifying left atrial (LA) fibrosis in cardiac magnetic resonance (CMR) images after persistent rapid ventricular pacing and subsequent AF using a canine model and histopathological validation.

Methods

Twelve canines (9 experimental, 3 control) underwent baseline 3D LGE-CMR imaging at 3T followed by insertion of a pacing device and 5 weeks of rapid ventricular pacing to induce AF (experimental) or no pacing (control). Following the 5 weeks, pacing devices were removed to permit CMR imaging followed by excision of the hearts and histopathological imaging. LA myocardial segmentation was performed manually at baseline and post-pacing to permit volumetric %MF quantification using the image intensity ratio (IIR) technique, wherein fibrosis was defined as pixels > mean LA myocardium intensity + 2SD.

Results

Volumetric %MF increased by an average of 2.11 ± 0.88% post-pacing in 7 of 9 experimental dogs. While there was a significant difference between paired %MF measurements from baseline to post-pacing in experimental dogs (P = 0.019), there was no significant change in control dogs (P = 0.019 and P = 0.5, Wilcoxon signed rank tests). The median %MF for paced animals was significantly greater than that of non-paced dogs at the 5-week post-insertion time point (P = 0.009, Mann Whitney U test). Histopathological imaging yielded an average %MF of 19.42 ± 4.80% (mean ± SD) for paced dogs compared to 1.85% in one control dog.

Conclusion

Persistent rapid ventricular pacing and subsequent AF leads to an increase in LA fibrosis volumes measured by the IIR technique; however, quantification is limited by inherent image acquisition parameters and observer variability.
The prevalence, risk factors analysis and evaluation of two diagnostic techniques for the detection of Cryptosporidium infection in diarrheic sheep from Pakistan
Authors: Khan Naimat Ullah , Usman Tahir , Sarwar Mian Saeed , Ali Hazrat , Gohar Ali , Asif Muhammad , Rabbani Fazli , Khan Rifat Ullah , Sultana Nighat , Khan Nazir Ahmad , Mobashar Muhammad , Shah Assar Ali , Wanapat Metha
Published: July 2022

Background

Cryptosporidium spp. is recognized as an opportunistic zoonotic parasite that infects humans as well as wild and domestic animals. This enteric protozoan is a major cause of diarrhea in humans and animals and often result in death due to severe dehydration. The present study was designed to investigate the prevalence, identification of various risk factors and evaluation of sensitivity of the two diagnostic techniques for rapid and correct detection of Cryptosporidium infection in diarrheic sheep in Pakistan.

Methods

A total of 360 fecal samples were collected and processed for detection of Cryptosporidium infection after proper preservation. These samples were properly stained with modified Ziehl-Neelsen acid staining and then examined under simple microscope at 100x magnification for confirmation of Cryptosporidium oocysts. The same samples were again processed through simple PCR for confirmation of the Cryptosporidium spp.

Results

The age wise prevalence was detected through simple microscopy and PCR. We found highest prevalence at the age of ≤1 year followed by 1–2 years of age while the lowest prevalence was recorded at the age of ≥ 2–3 years of sheep and found significant difference between different ages (P<0.05). The sex wise prevalence showed the highest prevalence in male (♂) animals detected compared to female (♀). The overall prevalence was detected 27.08% and 18.80% through PCR and simple microscopy, respectively, and significant difference between two diagnostic techniques were observed (P<0.05). Considering the seasonality, the highest prevalence was recorded through simple microscopy in autumn, summer, and spring, while the lowest in winter. These results were confirmed through PCR.

Conclusion

It was concluded that molecular detection is the most efficient, specific and sensitive technique for detection of Cryptosporidium infection than simple microscopy. Moreover sheep is the major potential source of infection to other wild and domestic animals including humans.
Do public employment services affect the self-rated health of migrant workers in China?
Authors: Li Lilian , Xu Bingxue , Chen Chunyan , Cheng Mingwang
Published: July 2022

Migrant workers greatly contributing to China’s industrialization and urbanization are confronted with increasing health risks. This study empirically investigates the effects of public employment services on the self-rated health of migrant workers in Shanghai China, by using data from the National Bureau of Statistics from 2015 to 2020. The estimation results under the Ordered Probit model illustrate that public employment services significantly improve the self-rated health of migrant workers, and vocational training, job development and other related services show an apparently positive correlation with the self-rated health. The marginal effect analysis reveals that public employment services obviously reduce the probability of health satisfaction as “average”, “relatively satisfied” and “relatively dissatisfied”, which translate into a significant increase in the probability of “very satisfied”. The mechanism analysis verifies that public employment services enhance the self-rated health by increasing the proportion of medical insurance and injury insurance of migrant workers. The results are still reliable by adopting the methods of subsample regression, Propensity Score Matching and variable substitution to conduct robustness checks. This study further enriches the literature on public employment services and the health status of migrant workers, and provides policy implications on improving the health status of migrant workers and the public employment service system of China under the impact of the COVID-19 pandemic.
Phenotypic and genotypic characterisation of thymine auxotrophy in Escherichia coli isolated from a patient with recurrent bloodstream infection
Authors: Jakovljev Aleksandra , Afset Jan Egil , Haugum Kjersti , Steinum Harald Otto , Gresdal Rønning Torunn , Samuelsen Ørjan , Ås Christina Gabrielsen
Published: July 2022

Introduction

Thymine auxotrophic in vitro mutants of Escherichia coli were first reported in the mid-20th century. Later, thymine-dependent clinical strains of E. coli as well as other Enterobacterales, Enterococcus faecalis and Staphylococcus aureus have been recognized as the cause of persistent and recurrent infections.

Objectives

The aim of this study was to characterize the phenotype and investigate the molecular basis of thymine auxotrophy in ten E. coli isolates obtained at different time points from a patient with recurrent bloodstream infection (BSI) due to a chronic aortic graft infection treated with Trimethoprim/sulfamethoxazole (TMP-SMX).

Methods

Clinical data was obtained from hospital records. Growth characterization and antimicrobial susceptibility testing to TMP-SMX was performed on M9 agar and in MH broth with different thymine concentrations (0.5, 2, 5, 10 and 20 μg/mL), on Mueller-Hinton (MH) and blood agar. Whole genome sequencing (WGS) was performed on all E. coli isolates.

Results

E. coli were isolated from ten consecutive BSI episodes from a patient with chronic aortic graft infection. Six of these isolates were resistant to TMP-SMX when assayed on blood agar. Growth experiments with added thymine confirmed that these isolates were thymine-dependent (thy-), and revealed growth defects (slower growth rate and smaller colony size) in these isolates relative to thy+ isolates (n = 4). WGS indicated that all isolates were of the same clonal lineage of sequence type 7358. Genomic analysis revealed a G172C substitution in thyA in all TMP-SMX resistant isolates, while mutations affecting genes involved in the deoxyribose salvage pathway (deoB and deoC) were identified in eight isolates.

Conclusion

This case highlights the risk of resistance development to TMP-SMX, especially for long-term treatment, and the possible pitfalls in detection of growth-deficient subpopulations from chronic infections, which could lead to treatment failure.
Analysis on process of temporal and spatial evolution of urban built-up area expansion in the Yellow River Basin
Authors: Fan Lin , Zhang Baifa , Wang Yihang , Zhao Wei , Dong Shuai
Published: July 2022

Urban spatial expansion is known as an important indicator of urbanization. In order to provide a reference for urban spatial expansion in the future high-quality development strategy of the Yellow River Basin (YB) cities in China, it is necessary to identify and calculate urban spatial expansion patterns. For this reason, we provide a "Spatiotemporal pattern-Center of gravity migrationt-Expansion pattern" solution to identify and calculate urban spatial expansion patterns in the YB. More specifically, 78 prefecture-level cities in the YB were selected as the subjects of the study, using the Defense Meteorological Satellite Program/Operational Line Scan System (DMSP/OLS) and the National Polarimetric Partnership/Visible Infrared Imaging Radiometer Suite (NPP/VIIRS) nighttime light data (NTL), together with the center of gravity shift and common edge detection models, to identify the YB urban expansion patterns from 2000–2018. The results suggest that: (1) on the spatial pattern, there is a obvious difference in the expansion intensity and growth rate of the urban built-up (UB) areas of cities in the upper and middle reaches of YB. In addition, there are also certain differences between the expansion patterns of provincial capital cities and non-capital cities; (2) The UB areas of YB has steadily expand from 3,500 km2 in 2000 to 10,600 km2 in 2018, amongst which the expansion of provincial capital cities is the most obvious 1919 km2; (3) Interestingly it is also discovered that urban expansion in Qinghai Province, the sourceland of the YB, takes place in a diffuse way, with the shifting of the centre of gravity for four types of total area, net increase in area, rate of growth and intensity of expansion followed a "northwest to southeast" tendency of development.
Sedation in specialized palliative care: A cross-sectional study
Authors: Hedman Christel , Rosso Aldana , Häggström Ola , Nordén Charlotte , Fürst Carl Johan , Schelin Maria E. C.
Published: July 2022

Background

Palliative sedation is used to relieve refractory symptoms and is part of clinical practice in Sweden. Yet we do not know how frequently this practice occurs, how decision-making takes place, or even which medications are preferentially used.

Objectives

To understand the current practice of palliative sedation in Sweden.

Methods

We conducted a retrospective cross-sectional medical record-based study. For 690 consecutive deceased patients from 11 of 12 specialized palliative care units in the southernmost region of Sweden who underwent palliative sedation during 2016, we collected data on whether the patient died during sedation and, for sedated patients, the decision-making process, medication used, and depth of sedation.

Results

Eight percent of patients were sedated. Almost all (94%) were given midazolam, sometimes in combination with propofol. The proportions of sedation were similar in the patient groups with and without cancer. The largest proportion of the sedated patients died in inpatient care, but 23% died at home, with specialized palliative home care. Among the patients with a decision to sedate, 42% died deeply unconscious, while for those without such a decision the corresponding figure was 16%. In only one case was there more than one physician involved in the decision to use palliative sedation.

Conclusion

8% of patients in specialized palliative care received palliative sedation, which is lower than international measures but much increased compared to an earlier Swedish assessment. The level of consciousness achieved often did not correspond to the planned level; this, together with indications of a scattered decision process, shows a need for clear guidelines.
Large-scale rollout of extension training in Bangladesh: Challenges and opportunities for gender-inclusive participation
Authors: Medendorp John William , Reeves N. Peter , Celi Victor Giancarlo Sal y Rosas , Harun-ar-Rashid Md. , Krupnik Timothy J. , Lutomia Anne N. , Pittendrigh Barry , Bello-Bravo Julia
Published: July 2022

Despite the recognized importance of women’s participation in agricultural extension services, research continues to show inequalities in women’s participation. Emerging capacities for conducting large-scale extension training using information and communication technologies (ICTs) now afford opportunities for generating the rich datasets needed to analyze situational factors that affect women’s participation. Data was recorded from 1,070 video-based agricultural extension training events (131,073 farmers) in four Administrative Divisions of Bangladesh (Rangpur, Dhaka, Khulna, and Rajshahi). The study analyzed the effect of gender of the trainer, time of the day, day of the week, month of the year, Bangladesh Administrative Division, and venue type on (1) the expected number of extension event attendees and (2) the odds of females attending the event conditioned on the total number of attendees. The study revealed strong gender specific training preferences. Several factors that increased total participation, decreased female attendance (e.g., male-led training event held after 3:30 pm in Rangpur). These findings highlight the dilemma faced by extension trainers seeking to maximize attendance at training events while avoiding exacerbating gender inequalities. The study concludes with a discussion of ways to mitigate gender exclusion in extension training by extending data collection processes, incorporating machine learning to understand gender preferences, and applying optimization theory to increase total participation while concurrently improving gender inclusivity.