bluuebunny/crossref_metadata_2025 huggingface dataset:
Step Function Intervention Analysis Model to Estimate Number of Aircraft Passengers in Minangkabau International Airport
Authors: Velya Rahma Putri  , Zilrahmi  , Syafriandi Syafriandi  , Dina Fitria
Published: September 2023

Pandemic of Covid-19 had a quite big impact in air transportation. Minangkabau International Airport (BIM) has also felt the impact of this pandemic, namely a drastic decrease in the number of airplane passengers or  there was an intervention event. Forecasting was carried out in this study to obtain an intervention model that will be used for forecast the next 12 months and predict how long the effect of the intervention will last for avoid further losses due to the continued decline in the number of passengers. The resultsof forecasting showed that the Seasonal ARIMA model (0,1,1)(1,1,1)12 b = 0, s = 8, r = 1 is the best model that can be used for forecasting data containing interventions. This is evidenced by the small MAPE of 36.34% so that the model is feasible to use because the accuracy is quite high and close to the actual value.
Penerapan Metode Self Organizing Maps (SOM) dalam Pengklasteran Berdasarkan Indikator Pemerlu Pelayanan Kesejahteraan Sosial (PPKS) Provinsi Jawa Barat
Authors: Hernanda Maulidya , Salma Admi , Vionanda Dodi , Martha Zamahsary
Published: September 2023

Salah satu Provinsi di Indonesia yang mengalami peningkatan jumlah penduduk miskin adalah provinsi Jawa Barat. provinsi jawa barat merupakan provinsi dengan jumlah penduduk miskin dan provinsi dengan jumlah penduduk terbanyak di indonesia, wilayah dengan populasi penduduk yang banyak justru memiliki masalah kesejahteraan sosial yang lebih kompleks. Pada penelitian ini dilakukan analisis klaster bagaimana hasil klaster kabupaten/kota di provinsi Jawa Barat serta mengidentifikasi karakteristik kelompok yang dihasilkan berdasarkan indikator Pemerlu Pelayanan Kesejahteraan Sosial (PPKS) menggunakan metode self organizing maps (SOM). SOM merupakan suatu metode unsupervised learning, dimana pada proses pelatihannya tidak memerlukan pengawasan (target output) yang menghasilkan representasi input kedalam dua dimensi (maps). pada penelitian ini diperoleh hasil 3 klaster dimana pada klaster 1 yang beranggotakan 24 kabupaten/kota memiliki nilai rataan relatif tinggi untuk setiap anggota dalam klaster, lalu pada klaster 2 yang beranggotakan kabupaten Cianjur dan kabupaten Karawang menunjukkan masalah kesejahteraan sosial yang tinggi dibandingkan klaster lain, dan untuk klaster 3 yang beranggotakan kabupaten bandung menunjukkan bahwa masalah kesejahteraan sosial yang paling menonjol adalah pada indikator perempuan rawan sosial ekonomi yaitu dengan rataan kasus sebanyak 34.549 jiwa/tahun. berdasarkan hasil yang diperoleh maka diperlukan pengambilan keputusan yang tepat terkait alokasi, sumber daya, perencanaan pelayanan yang lebih efektif, dan pengembangan program kesejahteraan sosial yang lebih tepat sasaran.
Application of the Fuzzy Time Series-markov Chain Method to the Rupiah Exchange Rate Against the US Dollar (USD)
Authors: Rahmad revi fadillah  , Dony Permana  , Yenni Kurniawati  , Admi Salma
Published: September 2023

The exchange rate holds great significance in analyzing the Indonesian economy, given its substantial influence on the overall economic landscape. By virtue of its dynamic characteristics, it is possible to engage in forecasting activities to anticipate forthcoming exchange rates. The aim of this research is to develop a prediction model using the Fuzzy Time Series (FTS) Markov chain method to forecast the Indonesian Rupiah's exchange rate against the US Dollar. Additionally, the study intends to determine the projected exchange rate of the Rupiah against the US Dollar for the upcoming season. Using the Fuzzy Time Series (FTS) Markov Chain method, the values of  and , which are precise positive  numbers, are determined by the researcher. Forecasting this level of sales result with =44.38 and = 11 generate error values (MAPE) of 0.2627525%. Forecasting for the next 21 days compared to data on sales of the rupiah against the USD dollar from January 2 2023 to January 31 2023 produces a MAPE value of 2.414564% with an accuracy rate of 97.58544%.
INVESTIGATION OF SEASONALITY IN EXACERBATION OF BIPOLAR AFFECTIVE DISORDER
Authors: Blazhina I.Yu. , Rusina S.M. , Kobevka V.M.
Published: September 2023

The aim of thе study – to review the literature regarding the search for patterns ofseasonality in exacerbations of phases in bipolar affective disorder.Conclusions. According to the literature, certain seasonal and climatic patterns ofexacerbation of the phases of bipolar affective disorder are observed, which can be usedto optimize therapeutic and preventive strategies.
A Study on the Origin and Development of Clothing
Authors:   The Korean Association of Practical Arts Education, Chung Mee-Kyung
Published: September 2023

This study aimed to provide basic humanistic data for clothing education by shedding light on
the origins and historical development of clothing. The study’s content encompassed the evolution of
mankind, the origin of clothing, and the development of clothing during the Paleolithic Age. The
study was conducted in the form of a literature review.
The study revealed several key findings. First, the evolutionary processes of Hospitalophithecus,
Homo habilis, Homo erectus, and Homo sapiens were characterized by constitutions such as 'bipedal
locomotion (upright walking),’ 'enhanced manual dexterity and tool-making abilities,’ ‘expansion of
brain capacity', and the 'reduction of body hair'. Enemy Evolution and 'Move Out of Africa'. This
progression ultimately led to the emergence of Homo erectus, the first archaic hominid to move out
of Africa with all the hallmarks of physical evolution. Subsequently, more advanced Neanderthals
and, later, Homo sapiens arrived in Europe about 50,000 years ago. Homo sapiens exhibited modern
human attributes, including high cognitive functions and the sophisticated development of the body
and hands.
Second, considering the constitutional characteristics of human evolution, the migration of early
humans from Africa to colder regions, and the loss of body hair, it is estimated that the earliest
forms of clothing were worn by Homo erectus between 1.8 million and 1 million years ago.
Third, the evolution of clothing during the Paleolithic period saw the development of fur waist
covers by Homo erectus, followed by the adoption of sloppy fur pants and tops by Neanderthal.
Homo sapiens, characterized by their cognitive prowess, advanced clothing by tailoring clothes using
needles. In the Late Paleolithic period, marked by cultural characteristics, clothing evolved to
include not only the weaving of cellulose fibers and the basic structural elements seen in
contemporary clothing, but it also reached a level of sophistication with neat and elaborate
decorations.
A Study on the Achievement Criteria of 2022 Agricultural Area in Revised Practical Arts Education on the Degrees of Interest, Understanding, and Importance of Teacher & Preparatory Teacher
Authors:   The Korean Association of Practical Arts Education, Kwack Hye Ran
Published: September 2023

This study has its purpose to investigate the interest, understanding, and importance of prospective
teachers and teachers in 2022 practical agricultural achievement standards to use them as evidence
for writing textbooks, field applications, and revising the next curriculum.
Degree of interest rates, understanding, and importance were all the highest in ‘sustainable
agriculture and agricultural circulation and ecological respect’ In importance, The future of
agriculture was also high, The future agricultural exploration of agricultural and agriculture related
to future agricultural and agricultural products.On the other hand, the the life technology of
plants in all areas, The Life Technology was all low. Overall, it is important to organize various,
accurate, and in-depth contents on the circularity of sustainable agricultural monster agriculture and
ecological respect newly proposed in 2022, and future agriculture and multiple values of
agriculture also needed a lot of attention. In addition, new and developed contents such as
understanding and classifying animal and plant resources and life technology of animal and plant
resources were urgently needed. The differences between pre-service teachers, future agricultural
experiences, garden experiences, and sustainable agricultural experience variables on the 2022 revised
agricultural area achievement standards are 'understanding and classifying animal resources',
'ecological respect', 'sustainable agricultural and agricultural circulation', 'future value of
agriculture'The differences in experience were significant differences in animal and plant-related life
technology, knowing how to grow and care animals, experiencing growing and caring animals,
and the cycle of sustainable agriculture. This was closely related to the corresponding experience
in each area. In particular, 'sustainable agriculture and agricultural circulation' showed significant
differences in interest, understanding, and importance, indicating that differences between variables or
experience have a large impact on the educational content.
Development of renewable energy and hydrogen energy in the Russian economy: problems and prospects
Authors: Fatueva E. A. , Shpilkina T. A. , Shishova I. A. , Filimonova N. N.
Published: September 2023

The presented publication reveals the issues of the development of the Russian energy sector. In the course of the study, the problems of greening and the use of ESG factors, the development of renewable energy and hydrogen energy in the country were analyzed.

The authors consider the advantages and disadvantages of various types of hydrogen, its use in industries, identify the prospects for the development of hydrogen energy in the Russian Federation and countries of the world, provide calculations on the cost of hydrogen production in Russia and abroad, show calculations of the export price for hydrogen produced by nuclear power plants, in order to identify the most effective options for its use, and the efficiency of use tidal, wind and solar power plants, which is relevant in the period of structural and technological restructuring of the economy.
An Overview of Activated Carbon Preparation from Various Precursors
Authors: Ahmad Normadyzah
Published: September 2023

Activated carbon plays an important role in the industry due to its uniqueness and special characteristics. Originally known as a good adsorbent, activated carbon has a very large surface area and high micro-porosity. Activated carbon has been widely used in petroleum, pharmaceutical, textiles and many other industries. Activated carbon can be derived directly from charcoal through chemical or physical activation. Nonetheless, activated carbon can also be obtained from other carbon precursors, such as biowaste (agricultural, municipal and industries) and natural resources (seed, leaves, fruits and barks). Generally, activated carbon can derive from wastes through four steps; pre-processing of raw materials, thermal-conversion steps (pyrolysis or carbonization), activation, and modification. Both activation and modification were employed in the production of activated carbon to boost its adsorption performance. These steps can be divided into chemical and physical steps that help alter the physical structure of activated carbon and modify the surface chemical properties of activated carbon. Due to its reliability as an adsorbent, activated carbon has been widely used to remove pollutants in wastewater treatment and the demand for activated carbon has been increasing every year. This article reviews methods for preparing activated carbon from various precursors and discussed their performances. This review article aimed to provide recent information on efforts made by various researchers in activated carbon preparation.
Vigilantes beyond borders. NGOs as enforcers of international law
Authors: Andrade-Vásquez Miguel
Published: September 2023

Vigilantes Beyond Borders: NGOs as Enforcers of International Law, de Mette Eilstrup-Sangiovanni y J.C Sharman (2022) es un libro que aborda el papel de las organizaciones no gubernamentales (ONG) como agentes independientes para la aplicación y el cumplimiento del derecho internacional. Los autores examinan el surgimiento de las ONG como actores en la política internacional y de qué forma se sirven de su influencia para promover la aplicación y el cumplimiento del derecho internacional. Buscan responder dos preguntas clave: ¿por qué hemos visto el reciente ascenso de agentes de ley no estatales en el nivel internacional?, y ¿por qué algunas ONG ejercen como agentes de ley mientras otras se mantienen con las estrategias tradicionales de apoyar o entregar servicios para los gobiernos? Para responderlas, se analiza el rol de estas organizaciones como vigilantes de la aplicación de la normativa internacional en el campo de los derechos humanos, el medio ambiente y la lucha contra la corrupción.
...
Los partidos políticos en México a través de las elecciones presidenciales, 1988-2018
Authors: Flores Andrade Anselmo
Published: September 2023

El estudio de los partidos políticos y del sistema de partidos en México cuenta con una abultada bibliografía. Desde una variedad de enfoques, análisis, perspectivas, propósitos e interés, cada uno de los estudios contribuyen al conocimiento de la génesis, desarrollo, declive, desempeño electoral, organización interna, grupos y facciones que los componen. El libro coordinado por el académico de la Universidad Iberoamericana, René Torres-Ruiz, Los partidos políticos en México a través de las elecciones presidenciales, 1988-2018, es de reciente aparición y contribuye a la bibliografía que busca explicar el surgimiento, desarrollo y declive de los partidos y el sistema de partidos en México durante los años de 1988 a 2018. Es esta una etapa crucial en la historia política del país, que comprende el largo e inacabado proceso de construcción de la democracia en México.
...
Fachspezifisches professionelles Wissen und Können von Sportlehrpersonen
Authors: Wittwer Matthias , Messmer Roland , Büchel Sonja
Published: September 2023

Während in diversen Unterrichtsfächern theoretische Konzeptionen und empirische Befunde zur Struktur von fachspezifischem Professionswissen (CK & PCK) vorliegen, befinden sich entsprechende Forschungsbemühungen im Fach Sport erst in den Anfängen. Der Beitrag geht der Frage nach, wie dieses Wissen bei Sportlehrpersonen empirisch strukturiert werden kann. Neben klassischen MC-Tests wurden auch Video- und Textvignetten eingesetzt, um sowohl kontextfernes als auch kontextualisiertes Wissen bzw. Können zu erfassen. Die Befunde der Befragung von 181 Sportlehrpersonen bestätigen die Zuverlässigkeit und Genauigkeit der Testinstrumente und zeigen sehr hohe Zusammenhänge zwischen den angenommenen Dimensionen. Jedoch deuten diese hohen Korrelationen darauf hin, dass eine Ausdifferenzierung des fachspezifischen Professionswissens bei Sportlehrpersonen kaum möglich ist.
Differentiation on Interval
Authors: Endou Noboru
Published: September 2023

This article generalizes the differential method on intervals, using the Mizar system [2], [3], [12]. Differentiation of real one-variable functions is introduced in Mizar [13], along standard lines (for interesting survey of formalizations of real analysis in various proof-assistants like ACL2 [11], Isabelle/HOL [10], Coq [4], see [5]), but the differentiable interval is restricted to open intervals. However, when considering the relationship with integration [9], since integration is an operation on a closed interval, it would be convenient for differentiation to be able to handle derivates on a closed interval as well. Regarding differentiability on a closed interval, the right and left differentiability have already been formalized [6], but they are the derivatives at the endpoints of an interval and not demonstrated as a differentiation over intervals.

Therefore, in this paper, based on these results, although it is limited to real one-variable functions, we formalize the differentiation on arbitrary intervals and summarize them as various basic propositions. In particular, the chain rule [1] is an important formula in relation to differentiation and integration, extending recent formalized results [7], [8] in the latter field of research.
Wohnungspolitik: das Paradoxon regulierungsbedingter Konsumentenrenten
Authors: Löhr Dirk
Published: September 2023

In the German housing market, rents in existing tenancies are relatively highly regulated, creating a significant gap with market rents. The resulting regulation-induced consumer rents lead to considerable efficiency losses and mismatches. Moreover, rent regulation is not socially accurate. The article takes a critical look at a recent proposal aimed at liberalising rental prices and extending housing allowance. This shall be financed by taxing landlords for the additional income generated by liberalisation. Although the proposal goes to the heart of the problem, it is neither purposeful nor feasible in this form.
The Unwelcoming Truth Behind Plasticizers in Healthcare
Authors: Shrestha Yash
Published: September 2023

First discovered in the early 1900s, plasticizers have caused controversy in the scientific community for decades (Oehlmann et al., 2009). Plasticizers are chemical substances that are added to plastic materials to promote flexibility and durability (Casale & Rice, 2022). In the healthcare setting, the most common plasticizer is a phthalate called di-2-ethylhexyl phthalate (DEHP). DEHP has a half-life of 50 days, and it is used in products like blood infusion and nasogastric tubing (Rowdhawl & Chen, 2018). The DEHP in these medical tubes tends to leach out during use in humans, or after heating and cleaning processes (Rowdhawl & Chen, 2018). Currently, there is a discussion on whether DEHP should continue to be used in the medical field. This debate stems from opposing scientific and economic viewpoints. On one hand, DEHP should be banned due to its plethora of harmful effects on the human body (LC50 = 0.50 ppm) and the environment (Rowdhawl & Chen, 2018). These conclusions have been gradually established based on findings in human and rat models. Conversely, opponents to this motion state that the toxic harms of DEHP are overexaggerated, and that the use of alternative plasticizers is ineffective. Those in favour of continuing DEHP use also claim that feasible alternatives are too expensive and dismantle healthcare budgeting. Nonetheless, despite their widespread use in the medical field, toxic plasticizers, like DEHP, should be banned in medical settings. The arguments geared towards banning DEHP hold more power in comparison to the superficial arguments supporting its use.
“HEAL - THE SYSTEM” E O USO DE JOGOS DIGITAIS NO ENSINO DE CIÊNCIAS BIOLÓGICAS E CONCEITOS EM VIROLOGIA
Authors: De Souza Vanessa Oliveira , De Souza Luciane Lopes , De Oliveira Raimundo Corrêa , Freitas Silvia Regina Sampaio
Published: September 2023

Estudos voltados para o campo das ciências biológicas, especificamente para o ensino da virologia, apresentam uma complexidade de assimilação por se tratar de microrganismos que só podem ser vistos por meio de microscópio. Tendo em vista que não são todas as escolas que possuem um laboratório com equipamentos necessários para tornar acessível esses conteúdos e as aulas tradicionais não são suficientes, foi proposto o uso de um jogo digital, denominado “Heal The System”, com o objetivo de contribuir com o processo de apropriação dos conceitos em virologia pelos estudantes no ensino de ciências. Este estudo baseado no método quantitativo, propôs a aplicação do jogo “Heal The System”  em uma escola da rede municipal de Manaus, estado do Amazonas, onde validou uma sequência didática que foi dividida em três momentos: aula expositiva sobre virologia e questionário pré-jogo, experiência com o jogo e questionário pós-jogo. Após a análise dos dados verificou-se que o jogo didático contribuiu para a aperfeiçoar o conhecimento sobre virologia para 90% dos alunos. Tantos alunos, quantos o professor, indicaram que a sequência didática complementada com o jogo didático digital favoreceu a compreensão e engajamento nesse campo da ciência.
LATIHAN DASAR KEPEMIMPINAN DAN ORGANISASAI MAHASISWA SEBAGAI UPAYA MENINGKATKAN JIWA KEPEMIMPINAN KAUM MILENIAL DI UNIVERSITAS GALUH
Authors: Arifin Nur Rizqi , Aida Depon Nurul , Saripudin Ayip , Yulisma Lia , Mulyanto Agus
Published: September 2023

Terdapat permasalahan rendahnya jiwa kepemimpinan dan organisasai mahasiswa pada Program Studi Pendidikan Biologi Universitas Galuh. Kegiatan ini dilaksanakan dengan tujuan untuk mendeskripsikan dan menganalisis tentang perencanaan, pengorganisasian, pelaksanaan, penilaian, dan solusi masalah yang dihadapi dalam latihan dasar kepemimpinan dan organisasai mahasiswa sebagai upaya meningkatkan jiwa kepemimpinan kaum milenial. Metode pelaksanaan dengan memberikan materi melalui pendekatan ceramah dan diskusi dimana peserta atau sasaran kegiatan pengabdian pada masyarakat adalah mahasiswa semester IV tahun akademik 2022/2023. Terdapat peningkatan yang signifikan dalam pemahaman materi latihan dasar kepemimpinan mahasiswa, yang merupakan langkah penting dalam meningkatkan jiwa kepemimpinan kaum milenial.
PENERAPAN 5S (SEIRI, SEITON, SEISO, SEIKETSU, SHITSUKE) PADA PENGECORAN LOGAM IKM WINTOLO DI YOGYAKARTA
Authors: Emaputra Andrean , Minan Nafi’ul , Astanti Ririn Diar , Mawadati Argaditia , Sekarjati Kartinasari Ayuhikmatin , Wibowo Agus Hindarto , Kustriyanto Kelvin Febry , Amami Ichza Nur , Ridho Muhammad
Published: September 2023

Lima S (5S) merupakan metode yang digunakan untuk meningkatkan kebersihan, keteraturan, dan kedisiplinan di lingkungan kerja. Terdapat kerja sama antara UPT Logam Dinas Perindustrian Koperasi Usaha Kecil dan Menengah Kota Yogyakarta, BKSTI Korwil 5 DIY, dan Prodi-Prodi Teknik Industri di DIY untuk meningkatkan kinerja IKM-IKM logam di Kota Yogyakarta. Salah satu IKM logam tersebut bernama IKM Wintolo yang terletak di Umbulharjo, DIY. Penataan alat-alat produksi di IKM Wintolo tersebut masih belum baik oleh karena itu IKM tersebut membutuhkan pelatihan dan penerapan 5S. Hal tersebut bertujuan untuk meningkatkan kecepatan produksi dari IKM tersebut. Kegiatan ini dilaksanakan pada bulan September-November 2022. Kegiatan ini dimulai dengan survai kondisi lingkungan kerja di IKM tersebut, pemberian materi tentang 5S, pemasangan rak dan labelnya di area kerja, serta penempatan barang-barang tersebut pada rak yang telah disediakan. Materi pelatihan dan rak penyimpanan barang dapat diterima dengan baik oleh IKM tersebut. IKM tersebut dapat melakukan aktivitas produksi dengan lebih cepat karena posisi alat-alat produksi sudah mudah ditemukan karena sudah memiliki tempat penyimpanan sendiri-sendiri. Kegiatan pelatihan dan penerapan 5S ini sangat bermanfaat bagi IKM tersebut karena dapat meningkatkan kecepatan proses produksi produk logam. Kolaborasi antara UPT Logam, BKSTI Korwil 5 DIY, dan prodi Teknik Industri dalam meningkatkan link and match di antara pelaku industri dan pelaku akademik sangat bermanfaat dalam memajukan IKM tersebut. Kegiatan kolaborasi seperti diharapkan dapat terus terjaga dan berlanjut demi kemajuan bersama antara pelaku industri dan pelaku akademik.
Variation of gingival crevicular fluid volume in early orthodontic tooth movement with clear aligner: A pilot study
Authors: Cremonini Francesca , Pavan Francesca , Pellitteri Federica , Palone Mario , Lombardo Luca
Published: September 2023

Objectives:

The objective of this pilot study was to evaluate the crevicular fluid volume (GCF) increase from a quantitative point of view in the first 8 hours of clear aligner treatment. Then, its variation and the amount of Orthodontic Tooth Movement (OTM) obtained with clear aligners was evaluated considering two different protocols, one of 20 h and one of 12 h.

Material and Methods:

A total of 10 healthy, adult patients were selected to participate in a split-mouth study where an orthodontic treatment with clear aligners was planned. Vestibular crown uncontrolled tipping was planned for upper lateral-posterior sectors. At 0H (baseline), and every hour for the first 8 hours of use, three GCF samples were collected. Then, all patients were asked to wear one random half of the upper aligner for 12 hours per day (Group 1) and the other half for 20 hours per day (Group 2). The GCF samples were measured using the Periotron 8000 device to quantify inflammation. Then, the amount of movement obtained was calculated by considering the FA point shift in mm with Geomagic X Control Software.

Results:

No differences were found between the extent of inflammation in terms of GCF volume and hours of intermittent force application (group 1 vs group 2).

Conclusion:

The amount of GCF assessed through Periotron 8000 increases significantly from the moment forces are applied through clear aligners. Considering the limitations of the following pilot study, it would appear that the GCF amount is directly related to the amount of movement obtained.
Verbalization of comparison in Platon Oyunsky's heroic epic "Djuluruyar Nyurgun Bootur" and in the Altai epic "Maadai Kara"
Authors: Zakharova A. M.
Published: September 2023

The article considers the ways of expressing comparative relations in the Yakut and Altai heroic epics. The related Yakut and Altaic languages are currently being actively studied in comparative terms in order  to  identify  speciﬁc  differences.  The  comparative  construction  was  previously  studied  in  the  Yakut language by Yu. I. Vasilyev, theoretical coverage was given by E. I. Ubryatova; in the Altai language the comparative construction was specially studied by L. N. Tybykova. The material of the study was the Yakut heroic epic "Djuluruyar Nyurgun Bootur" ("Nurgun Botur the Swift") and the Altai epic "Maadai Kara".
Application of geochemical methods for direct prediction of hydrocarbon deposits in Western Yakutia
Authors: Rudykh I. V.
Published: September 2023

Based on the materials previously carried out by various types of geochemical surveys (water-gas, hydrochemical, litho-gas-geochemical, snow, atmochemical, bituminological sampling), an analysis of the oil and gas potential prospects of the eastern part of the Siberian platform within the Sakha Republic (Yakutia) established a direct relationship between the anomalies and the proven oil and gas potential of the studied territories. The indicators of geochemical field anomalies are an order of magnitude higher within territories with proven oil and gas potential (Nepa-Botuobinskaya anteclise) than in the territories where they are absent, including oil and gas fields that have been discovered to date (Syugdzherskaya structural low). A striking example is the geochemical research carried out within the Chayanda oil and gas condensate field, where the confirmation of deposits by drilling, using geochemical data, increased by 30 %, which indicates the validity of the use of geochemical analysis methods in the search for oil and gas. Based on the analysis of the data presented, when predicting and searching for hydrocarbon accumulations, the most rational approach is to carry out mandatory advanced zoning of large territories according to the level of geochemical background.
Enhancing FAIRdata by providing digital workflows from data generation to the publication of data: an open source approach described for cyclic voltammetry
Authors: Herrmann David , Hodapp Patrick , Starman Martin , Huang Pei-Chi , Lin Chia-Lin , Le Lan , Klar Jochen , Bizzarri Claudia , Roese Philipp , Oppel Niklas , Fischer Tillmann G. , Tremouilhac Pierre , Holzhauer Laura , Herres-pawlis Sonja , Hoffmann Alexander , Seitz Tobias , Zeitler Kirsten , Dorn Alrik , Jung Nicole , Bräse Stefan
Published: September 2023

Analytical data in chemistry and other disciplines is usually generated in different formats and lacks common data and metadata standards that are necessary for a FAIR handling of research data. In the work presented herein, we describe a workflow that uses non-standardized, in some cases proprietary data formats from cyclic voltammetry measurements coming from individual devices as an instructive example, to yield open, standardized data that are annotated with rich metadata. The presented workflow includes concepts, software and infrastructure that can be used to support the whole data life cycle from the measurement of data to the publication of data and metadata in repositories. Components used for this workflow were made available as open source, allowing the re-use of this approach in other laboratories. The methods described for cyclic voltammetry can be adapted and used for other measurements and experimental data collections, allowing for an easy way to integrate new methods for digitalized research and FAIR data management.
Photoswitchable Inhibitors of the Sarco(endo)plasmic Calcium Pump
Authors: Hjorth-Jensen Samuel , Konrad David , Quistgaard Esben , Hansen Line , Novak Alexander , Chu Hang , Jurášek Michal , Zimmermann Tomáš , Andersen Jacob , Baran Phil , Nissen Poul , Trauner Dirk
Published: September 2023

Targeting the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) offers a promising strategy for treating drug-resistant cancers. However, as SERCA activity is essential for all cells types, specific inhibitors such as thapsigargin (TG) possess general toxicity. We explored the potential for developing SERCA inhibitors controllable with light by synthesizing TG derivatives containing an azobenzene photoswitch. These compounds (AzTG derivatives) were assessed by their ability to inhibit SERCA ATPase activity. We have identified cis-active and trans-active derivatives and our results reveal a ~2-fold difference in IC50 in response to photoisomerization, demonstrating an effect of the incorporated photoswitch. Furthermore, X-ray structures of SERCA in complex with two AzTG derivatives were obtained, revealing two different binding modes for the photoswitch group of these compounds. Taken together, we have developed photo-activatable SERCA inhibitors that can serve as tools to study the function of their target protein, and our results build the foundation for the design of improved, next-generation photoswitchable inhibitors.
Discussion on designing three chemical instruments
Authors: Luo Jiehong
Published: September 2023

This paper talks about how to use our soft ionization mass spectrometry theory to design three instruments. Including ion source, mass spectrometer, Instrument for measuring single bond forces between atoms
Composite LFP cathode/current collector microfiber-meshes with bi- and interlayered architectures for Li-ion battery
Authors: Mados Edi , Atar Inbar , Kondrova Olga , Golodnitsky Diana , Sitt Amit
Published: September 2023

In this study, we report the development of a free-standing fiber-based mesh cathode made of electrospun composite microfibers containing 80wt% lithium iron phosphate (LFP), as well as conductive microfibers containing carbon nano-fillers acting as the current collector (CC). Scanning electron microscopy confirmed that the meshes are constructed of well-shaped microfibers and exhibit a high porosity, enabling efficient electrolyte penetration and improved electron and ion-transport channels. Two cathode architectures of the LFP/polymer-based CC meshes were explored: bilayered and interlayered. Both are characterized by a high surface-to-volume ratio. The interlayered structure showed superior electrochemical performance due to enhanced LFP-CC fiber-to-fiber contacts and reduced resistance. Comparative analysis with electrospun LFP on aluminum foil revealed comparable specific capacity but higher polarization in the electrospun LFP/PBCC meshes, attributed to increased internal resistance and limited fiber-to-fiber contacts. However, the electrospun interlayered LFP/CC mesh exhibited significantly higher gravimetric energy density (197 Wh/kg (LFP+PBCC) and 94 Wh/kg (LFP+Al), respectively), offering lightweight and higher-energy-density electrode materials, thus guiding the design of high-performance flexible lithium-ion batteries.
Manipulation of Charged Porous Cages as Tunable Platforms for Selective Gas Adsorption
Authors: Deegan Meaghan , Antonio Alexandra , Korman Kyle , Ezazi Andrew , Yap Glenn , Powers David , Bloch Eric
Published: September 2023

Despite the extensive development of metal-organic framework (MOF) chemistry over the past two decades, systems capable of engag-ing in metal-to-ligand π-backbonding interactions remain limited. Further development of this subset of metal-organic materials is of particular interest for tunable small molecule activation, with potential applications in selective adsorption and catalysis. To complement existing MOFs, our group has focused on expanding the chemistry of porous coordination cages (PCCs) as highly tunable building blocks for porous material design. Porous salts assembled from oppositely charged PCCs are a particularly promising class of materials for accessing highly tunable porous phases. To expand porous salt chemistry, we set out to develop approaches for incorporating coordina-tively unsaturated, π-basic transition metal centers in these materials, as demonstrated, in this case, by their behavior toward carbon mon-oxide chemisorption and activation. In this study, we outline an approach to accessing π-basic ruthenium sites in a charged porous coor-dination cage and explore its incorporation in porous salts. We demonstrate that a non-porous molecular ruthenium complex can simi-larly be incorporated as the charge balancing counterion of a porous cage to access phases that exhibit similar selectivity for carbon mon-oxide chemisorption. We anticipate that the design principles outlined in this study will prove to be of broad utility for tailoring porous salts to diverse applications.
Identification of (+)-7R-Actinidine and its Biosynthetic Pathway in Rove beetles, Cafius spp. (Coleoptera: Staphylinidae)
Authors: Takatani Yu , Ohata Yuto , Inoue Takato , Mori Naoki
Published: September 2023

Actinidine, a terpene alkaloid, is commonly found in various plants and insects. However, in recent years, it has been suggested that the presence of actinidine in these organisms may be due to artifacts resulting from heating during sample preparation and analysis. In this study, actinidine was successfully isolated and identified from rove beetles, specifically Cafius vestitus and Cafius pectoralis, using a nonheating extraction and purification method. Gas chromatography/mass spectrometry (GC/MS) and nuclear magnetic resonance analyses confirmed actinidine production by these rove beetle species. Additionally, employing a chiral column for GC/MS analysis revealed that the compound is (+)-7R-actinidine, marking its first discovery in natural products. To elucidate the actinidine biosynthesis pathway, D-glucose-1-13C and mevalolactone-2-13C were fed to C. vestitus. Results indicated that both compounds were incorporated into actinidine in the beetles, leading to the conclusion that C. vestitus accumulates (+)-7R-actinidine, which is derived from the mevalonic acid pathway.
Construction of Diiron Diamond-Core Complexes Influenced by a Fluoroalkoxide Ligand
Authors: Chacon-Teran Miguel A. , Creutz Sidney E. , Rodriguez-Lugo Rafael E. , Kajetanowicz Anna , Grela Karol
Published: September 2023

The FenXn scaffold (X= p-block elements) occurs commonly in multimetallic metalloproteins and metalloenzymes. In particular, the synthon Fe2X2 is of great interest for biomimetic studies. Here is presented the use of α,α-bis(trifluoromethyl)benzyloxide as a ligand to support the assembly of two heteroleptic iron complexes featuring a diamond-core structure of the type Fe2X2 (X = N(SiMe3)2, HMDS; O-2,6-(2’,4’,6’-Me3-C6H2)2-C6H3, HMTO). The relatively low Lewis basicity of the fluoroalkoxide ligand cause it to selectively occupy the terminal position at the iron centers, while the more basic amido or alcoxo donors X are bridging the iron atoms and thus force them to take part in the diamond-core scaffold Fe2X2. In solution, even at room temperature, the amide-bridged diamond-core compound features a stable dimeric structure, exhibiting low-coordinate iron centers and a strong intermetallic antiferromagnetic interaction, as supported by experimental data and theoretical calculations.
Diseño y fabricación de máquina para refuerzo de ejes para turbinas eólicas de eje vertical con un material compuesto
Authors: Urbano Javier , Contreras González Paula Alejandra , Pedraza Ochoa Juan Andrés , Hernández Carrillo Yerson Santiago , Arias Anderson Julián
Published: September 2023

Mejorar la eficiencia de turbinas eólicas de eje vertical es un reto de creciente interés científico y comercial a nivel mundial, buscando aprovechar al máximo el recurso eólico disponible en los diferentes escenarios donde es aprovechable. Este reto tiene diversos enfoques, entre ellos está la mejora aerodinámica con mayor despliegue investigativo y un enfoque de menor relevancia científica, pero no menos importante, que es el diseño mecánico de los componentes necesarios para transmitir la energía aprovechada del viento. El desarrollo de partes mecánicas para mejorar la eficiencia de turbinas Eólicas está enfocado principalmente en disminuir el consumo de energía requerida y las pérdidas para la transmisión de la energía colectada. Disminuir la energía consumida en el movimiento de las partes, se consigue disminuyendo el peso del eje de transmisión de potencia, lo que va en contraposición a los requisitos de seguridad derivados de la exigencia a la que está sometido este componente. En este trabajo, se presenta el proceso de diseño prescriptivo de un equipo para refuerzo de ejes metálicos con materiales compuestos, y la puesta a punto de este de tal forma que permita fabricar ejes reforzados con una amplia versatilidad de variables geométricas. El diseño desarrollado se fabricó en las Instalaciones de la Universidad Escuela Colombiana de Ingeniería Julio Garavito y permite realizar el proceso semiautomatizado de refuerzo para ejes de longitudes entre 100 a 1400mm y diámetros que pueden varias entre 25 a 100mm, puede realizar el proceso de bobinado con diferentes ángulos y números de capas. Este diseño permitirá construir ejes en diferentes configuraciones para investigar de forma experimental el comportamiento de este tipo de elementos, como componentes novedosos en las turbinas de viento de eje vertical desarrolladas por la Institución.
Análisis de la variación de la turbidez a partir de imágenes Sentinel 2 en la bahía de Cartagena – Colombia
Authors: Eljaiek Urzola Mónica , Quiñones Bolaños Édgar , Sander de Carvalho Lino Augusto , Betancur Turizo Stella Patricia
Published: September 2023

La calidad del agua de la bahía de Cartagena se ha venido deteriorando producto del aporte de sedimentos del canal del Dique. Los impactos de dichos aportes sobre la calidad del agua de la bahía, se estudian a partir de campañas semestrales, integradas por 11 estaciones de monitoreo, dentro de las cuales se hacen mediciones de sólidos suspendidos totales, que varían entre 13 y 470 mg/l. Esta información es muy útil, sin embargo, se requieren esfuerzos adicionales para conocer la dinámica espacial y temporal de los sólidos en suspensión en la bahía, para lo cual se requeriría realizar campañas de monitoreo más frecuentes y en muchas más estaciones, generándose mayores costos. En ese sentido, para complementar la medición in situ, una alternativa que está resultando cada vez más habitual es la del monitoreo con sensores remotos o teledetección, con la que se obtendría una mayor cantidad de datos, gracias a la posibilidad de ampliar la cobertura espacial y temporal. En este artículo se presenta el análisis del comportamiento espacial durante el año 2022 de los niveles de turbidez de la bahía de Cartagena-Colombia, usando imágenes Sentinel 2. Para lograr este objetivo, se desarrolló un algoritmo empírico de turbidez que relaciona la reflectancia satelital en la longitud de onda 665 nm y la turbidez del agua. En la calibración del algoritmo se obtuvo un R2 de 0.7. En la validación se obtuvo un R2 = 0.83 con un RMSE de 2.72 y un MAPE de 24.93%. Producto de la modelación del comportamiento de la turbidez con imágenes Sentinel 2, se pudo observar la variabilidad estacional de la zona, definida por mayores niveles de turbidez en la época de lluvia, con un promedio en la bahía de 20.4 FNU en el mes de septiembre, en contraste con un promedio de 9.2 FNU en el mes de enero, asociado a la época seca. Estos resultados, permitieron establecer la zona sur de la bahía, como la zona con mayores variaciones de turbidez, con un coeficiente de variación hasta del 67%.
Explorando la aplicación de las redes neuronales en la detección y cuantificación de residuos orgánicos: un aporte de la inteligencia artificial a la economía circular
Authors: Reyes Castaño Nelson Mauricio , Alzate Ibáñez Angélica María
Published: September 2023

La transición hacia un modelo de economía de ciclo cerrado en la cadena agroalimentaria ha hecho evidente la necesidad de desarrollar soluciones innovadoras, que permitan el aprovechamiento de las pérdidas y los desperdicios de alimentos, el uso sostenible de los recursos, y la reducción del impacto ambiental en las diferentes etapas de la cadena productiva. Este trabajo presenta la detección y clasificación de los residuos de alimentos generados en centros de distribución y de retail de alimentos, mediante la aplicación de herramientas de inteligencia artificial. La investigación se basa en la recopilación de datos de los residuos generados de la distribución y comercialización de frutas y verduras en la ciudad de Bogotá. El conjunto de imágenes se procesa a través de técnicas de aprendizaje profundo con bloques de segmentación compilados en Python para la detección, clasificación y categorización de los desperdicios en diferentes escenarios de prueba. Los resultados obtenidos pueden ser utilizados para la predicción del comportamiento de los residuos generados en la etapa de distribución y retail de la cadena de suministro, y el análisis de posibles estrategias de aprovechamiento en el modelo de economía circular. Como trabajo futuro se espera que la integración de las herramientas de inteligencia artificial contribuya a la mejora en la eficacia y eficiencia en la gestión de residuos, y al logro de los objetivos de sostenibilidad de la cadena agroalimentaria.
Software libre para la optimización de sistemas de iluminación
Authors: Revelo Obando Luisa Fernanda , Aguirre Arcos Laura Nathalia
Published: September 2023

El sistema de iluminación es uno de los factores clave para el diseño arquitectónico y constructivo de las edificaciones. En ocasiones, la disposición de la iluminación en espacios ha sido ineficiente desde la fase de diseño, en tanto que, los entornos de vida de las personas se han visto afectados, entre los que se destaca los determinantes sociales de la salud (DSS). Lo anterior refleja la necesidad de revolucionar y modificar los parámetros de diseño mediante el uso de softwares libres como DiaLUX. Esta herramienta puede usarse desde un equipo móvil y computador, y por su versatilidad, permite crear escenas de iluminación únicas y atmósferas especiales adaptadas a las necesidades de las personas y a las normatividades vigentes a nivel local y global. El objetivo del presente artículo es presentar las diferentes ventajas que ofrece el software respecto a su uso en la disposición de sistemas de iluminación que cumplan con la normativa vigente en Colombia. El desarrollo de la investigación inició con una consulta exploratoria de los reglamentos técnicos y resoluciones que regulan la disposición y los parámetros de diseño de iluminación en Colombia, así como la consulta sobre el uso del software. Teniendo las herramientas teóricas, se realizó el acercamiento a la interfaz del software, mediante el diseño y ambientación de un espacio de oficina. La interfaz de DiaLUX resultó muy amigable e intuitiva y facilitó recrear escenas de iluminación y atmósferas únicas. Como resultado, esta versión gratuita, multidioma, con una librería (LUMSEARCH) y diferentes catálogos en línea, permitió trabajar con productos de última generación en las simulaciones de iluminación del espacio seleccionado. Además, el correcto diseño de los sistemas de iluminación mediante este software posibilitó la modelación de condiciones adecuadas para el bienestar de los usuarios de la oficina. Finalmente, este tipo de estudios puede replicarse en edificaciones de mayor magnitud.
Modelo predictivo para el pronóstico temprano de gravedad en pacientes con diagnóstico de neumonía en unidades de cuidado intensivo
Authors: Camacho Javier , Bonet Isis , De la Rosa Gisela , Barrera Jeisson
Published: September 2023

La neumonía es considerada como una infección pulmonar causada por múltiples microorganismos (bacterias, virus u hongos), clasificada en dos tipos según se adquiera, que son; neumonía adquirida por la comunidad (extrahospitalaria), donde generalmente su fuente es una bacteria llamada neumococo y la neumonía hospitalaria (intrahospitalaria), donde su origen son los centros hospitalarios, con bacterias poco comunes en la comunidad. La neumonía se ha identificado como la infección intrahospitalaria más común, con una prevalencia de 26%, donde el 35% de los casos hacen referencia a neumonía asociada al ventilador. Neumonía intrahospitalaria puede ser mortal, debido a que los pacientes que la contraen ya se encuentran hospitalizados por lo que ya están enfermos y su sistema inmune no puede combatir los microbios. Esta infección ataca al sistema respiratorio del paciente, por lo que en la mayoría de los casos es necesario conectar al paciente a un ventilador mecánico o ingresarlo a la unidad de cuidados intensivos (UCI). Una vez el paciente se encuentra hospitalizado en UCI, su condición de salud es inestable y delicada por lo que es muy importante vigilarlo continuamente y evitar desenlaces mortales. Mediante este proyecto se pretende desarrollar un modelo que permita generar un pronóstico temprano de la gravedad de los pacientes diagnosticados con neumonía en UCI, ofreciendo una herramienta que le permita al personal asistencial agilizar los tratamientos en aquellos pacientes más críticos e incluso salvarles la vida. Para el diseño del modelo se utilizaron técnicas de inteligencia artificial basadas en la última generación de árboles de decisión (Light Gradient Boosting Machine), utilizando como base de conocimiento bases de datos anonimizadas de las UCI de una institución de salud norteamericana (MIMIC III) y potencial aplicación a un Hospital de tercer nivel de la ciudad de Medellín.