bluuebunny/crossref_metadata_2025 huggingface dataset:
Ridership and Human Mobility of Metro System Under the Typhoon Weather Event: A Case Study in Fuzhou, China
Authors: Jiang Shixiong , Lin Yuchen
Published: February 2022

Extreme weather events, such as typhoon and hurricane, have characteristics of high uncertainty, large destructiveness, and extensiveness, which threat the daily life and cause apparent perturbations to human mobility. In order to investigate the perturbation on human mobility, this study collects the metro transaction data before and during a typhoon weather event in Fuzhou, China, to conduct analyses. The ridership before and during the typhoon weather event is innovatively compared at system, station and origin-destination level. Besides, it is of novelty to examine the travel time distribution of metro trips in the normal and perturbed state by comparing three candidate models with the Akaike information criterion method. Results validate that the typhoon weather event severely influences the ridership at system, station, and origin-destination level, with various degrees. There is also significant impact on the relative total traveled stations from the typhoon weather event, especially for leisure trips. Moreover, the travel time of metro trips follows the gamma distribution in both the normal state and the perturbed state with different magnitudes. It is found that both the number of traveled stations and travel time are lower in the typhoon state when compared to those in the normal state. In general, this study can provide some helps to assist the metro management under extreme weather events.
Large-scale dark matter simulations
Authors: Angulo Raul E. , Hahn Oliver
Published: February 2022

We review the field of collisionless numerical simulations for the large-scale structure of the Universe. We start by providing the main set of equations solved by these simulations and their connection with General Relativity. We then recap the relevant numerical approaches: discretization of the phase-space distribution (focusing on N-body but including alternatives, e.g., Lagrangian submanifold and Schrödinger–Poisson) and the respective techniques for their time evolution and force calculation (direct summation, mesh techniques, and hierarchical tree methods). We pay attention to the creation of initial conditions and the connection with Lagrangian Perturbation Theory. We then discuss the possible alternatives in terms of the micro-physical properties of dark matter (e.g., neutralinos, warm dark matter, QCD axions, Bose–Einstein condensates, and primordial black holes), and extensions to account for multiple fluids (baryons and neutrinos), primordial non-Gaussianity and modified gravity. We continue by discussing challenges involved in achieving highly accurate predictions. A key aspect of cosmological simulations is the connection to cosmological observables, we discuss various techniques in this regard: structure finding, galaxy formation and baryonic modelling, the creation of emulators and light-cones, and the role of machine learning. We finalise with a recount of state-of-the-art large-scale simulations and conclude with an outlook for the next decade.
Mapping out the Trajectory of Islamic Perspectives on Neuroethics
Authors: Noorfuad Noorina
Published: February 2022

The advancements of medical technology incited multi-disciplinary discussions with regard to its ethical implications. Within the neuroscientific domain, the term ‘neuroethics’ has gained prominence over recent years. However, the contributions of religious perspectives in the nascent field of neuroethics are particularly few. The scarce literature on Islamic perspectives on neuroethics merely questioned its importance and introduced a sharia-based framework that can be implemented. Building upon this, the possible trajectories of Islamic perspectives on neuroethics can be mapped out by tapping into several issues within Islamic bioethics, such as cloning and genomics. Topics such as these are deliberated through the collective discussions by contemporary Muslim scholars and biomedical scientists, thus producing well-informed dialogues and decisions. Building upon these may assist in developing further the Islamic perspectives on issues within neuroethics. This lays the groundwork for all the stakeholders involved in advance, in order to predict and prevent potential harms and challenges.
How did women’s education and differential family planning policies shape transition to second and third births in historical China? New evidence from micro data
Authors: Qin Min , Padmadas Sabu S. , Falkingham Jane
Published: February 2022

The influence of China’s family planning policies on fertility transition is widely acknowledged in research studies. However, little is known about how improvements in women’s education have shaped reproductive decisions of Chinese women across different family planning regimes, particularly at micro level. This study uses retrospective pooled birth history data from five consecutive population and family planning surveys collected over the period 1982–2006 to systematically examine the interrelationship between family planning policies and women’s education, and their interactive effect on the second and third birth transitions. We hypothesize that family planning policies had a differential influence on educational groups in reducing the transition to second and third births. The results from discrete time complementary log–log survival models provide strong evidence of differential reproductive behavior of education groups across time in China, and the simultaneous influence of women’s education and family planning policies in lowering risks to higher parities. The rates of progression to second and third births tend to be lower after the introduction of rigid family planning policies, and more importantly, the policy impact persisted even after adjusting for demographic and socioeconomic factors. The increase in women’s education overall had a depressing effect on transition to higher parities, and family planning policies implemented overtime have had differential effects on women from different educational groups. The findings show that both family planning policies and women’s education have been instrumental in shaping fertility behavior in China.
Maternal Blood-Based Protein Biomarkers in Relation to Abdominal Fat Distribution Measured by Ultrasound in Early Mid-Pregnancy
Authors: Lindberger Emelie , Wikström Anna-Karin , Sundström Poromaa Inger , Ahlsson Fredrik
Published: February 2022

The objective of this study was to examine the associations of early mid-pregnancy ultrasound measured visceral and subcutaneous fat depths with blood-based protein biomarkers. This was a cross-sectional study including 201 pregnant women at Uppsala University Hospital, Sweden. The mean age of the women was 31.0 years, and 57.7% were nulliparous. Maternal visceral and subcutaneous fat depths were measured by ultrasound at the early second-trimester anomaly scan. A non-fasting blood sample was collected in conjunction with the second-trimester anomaly scan, and the Olink cardiovascular II panel was used to measure 92 blood-based protein biomarkers in the sample. Cross-sectional associations of visceral and subcutaneous fat depths with blood-based protein biomarkers were examined using Mann–WhitneyUtests with false discovery rate adjustments. In addition, linear regression analyses adjusting for maternal age, parity, and early pregnancy body mass index were performed. The results showed differences in one biomarker between women with elevated (≥ 52 mm) versus normal (< 52 mm) visceral fat depth, and in three biomarkers between women with elevated (≥ 22 mm) versus normal (< 22 mm) subcutaneous fat depth. Hence, levels of blood-based protein biomarkers differ between pregnant women with dissimilar body fat distributions, which might reflect disparities in biological pathways.
Transonic small disturbance unsteady potential flow over very high aspect ratio wings
Authors: Kwon J. R. , Vepa R.
Published: February 2022

In this paper, the prediction of the unsteady flow field over typical high aspect ratio (AR) wings in the transonic flow regime but below the sonic Mach number is of interest. The methodology adopted is a computational approach based on the transonic small disturbance unsteady potential equation. It is shown that the higher AR wings generally have a higher lift coefficient as well as a higher lift-to-drag ratio. With NASA’s common research model (CRM) wing, there is an increase in maximum lift with increasing AR while the induced drag is almost the same. There is also an optimum sweep angle, which is different for each angle-of-attack so that variable sweep lifting surfaces may be designed to provide optimum solutions. The computed flutter speeds indicate an expected reduction with increasing AR.
The Usambara Knowledge Project: Place as Archive in a Tanzanian Mountain Range
Authors: Conte Chris
Published: February 2022

The essay chronicles the early phases of a digital history project on landscape change in the mountains of eastern Tanzania. In collecting sources for a land and culture narrative, the project aims ultimately to create an archive that is locally produced in Tanzania and maintained by Utah State University Library’s Special Collections and Archives division. The project draws on more than thirty early twentieth-century landscape photographs from the Usambara Mountains in northeastern Tanzania by Walther Dobbertin, a professional photographer living in German East Africa. In the fall of 2015, team members scouted the sites for repeat photographs. The following summer, the project team began repeat photography and expanded the range of local collaborators to develop an oral history collection tied to the region’s landscape history. The essay lays out the problems, pitfalls, and successes of the preliminary collaborative work among academics, university students, archival specialists, and elders’ groups intent on collecting and preserving knowledge.
Reflection of rightward moving shocks of the first and second families over a steady oblique shock wave
Authors: Wang Miao-Miao , Wu Zi-Niu
Published: February 2022

The reflection of rightward moving shocks (RMSs) belonging to the first and second families, over an initially steady oblique shock wave (SOSW) produced by a wedge, is studied in this paper. Various possible combinations of primary reflection (reflection at the intersection point of the RMS and the SOSW) and secondary reflection (reflection, on the wedge, of reflected shock waves of the primary reflection) are identified and the transition conditions are studied. For an RMS of the first family, the shock reflection problem can be shown to be equivalent to a shock interference problem. If the wedge angle is large, then the problem is equivalent to a shock interaction problem with two incident shock waves of the same family so that we have type VI, type V and type IV shock interferences. Interestingly, when the wedge angle is small enough, deflection angle reversal is observed for the SOSW so that the right part of the SOSW can no longer be regarded as one incident shock wave. It is now the left part of the SOSW that becomes one incident shock wave. As a result, for a small wedge angle, type I or type II shock interference is observed. If the RMS belongs to the second family, then the primary reflection may have regular and Mach reflections, and one reflected shock of this primary reflection reflects over the wall as another pseudo-steady shock reflection, while the other reflected shock wave may be smooth or have a kink or a triple point, as in single, transitional and double Mach reflection of pseudo-steady shock reflection.
Physics-guided deep learning for generating turbulent inflow conditions
Authors: Yousif Mustafa Z. , Yu Linqi , Lim HeeChang
Published: February 2022

In this paper, we propose an efficient method for generating turbulent inflow conditions based on deep neural networks. We utilise the combination of a multiscale convolutional auto-encoder with a subpixel convolution layer (

${\rm MSC}_{\rm {SP}}$

-AE) and a long short-term memory (LSTM) model. Physical constraints represented by the flow gradient, Reynolds stress tensor and spectral content of the flow are embedded in the loss function of the

${\rm MSC}_{\rm {SP}}$

-AE to enable the model to generate realistic turbulent inflow conditions with accurate statistics and spectra, as compared with the ground truth data. Direct numerical simulation (DNS) data of turbulent channel flow at two friction Reynolds numbers

$Re_{\tau } = 180$

and 550 are used to assess the performance of the model obtained from the combination of the

${\rm MSC}_{\rm {SP}}$

-AE and the LSTM model. The model exhibits a commendable ability to predict instantaneous flow fields with detailed fluctuations and produces turbulence statistics and spectral content similar to those obtained from the DNS. The effects of changing various salient components in the model are thoroughly investigated. Furthermore, the impact of performing transfer learning (TL) using different amounts of training data on the training process and the model performance is examined by using the weights of the model trained on data of the flow at

$Re_{\tau } = 180$

to initialise the weights for training the model with data of the flow at

$Re_{\tau } = 550$

. The results show that by using only 25% of the full training data, the time that is required for successful training can be reduced by a factor of approximately 80% without affecting the performance of the model for the spanwise velocity, wall-normal velocity and pressure, and with an improvement of the model performance for the streamwise velocity. The results also indicate that using physics-guided deep-learning-based models can be efficient in terms of predicting the dynamics of turbulent flows with relatively low computational cost.
Marangoni instabilities of droplets on the liquid substrate under the action of a spatial temperature modulation
Authors: Nepomnyashchy Alexander , Simanovskii Ilya
Published: February 2022

The dynamics of a droplet on an inhomogeneously cooled liquid substrate is investigated numerically. The longwave approximation is applied. It is shown that spatial temperature modulation leads to the droplet's motion towards the region of lower temperature, which is accompanied by the change of the droplet shape. An intensive cooling from below can lead to periodic or quasiperiodic oscillations or the droplet's decomposition. A spatial temperature modulation can suppress the oscillatory instability.
Postscript to Richard Jeffrey’s “Conditioning, Kinematics, and Exchangeability”
Authors: Wagner Carl G.
Published: February 2022

Richard Jeffrey’s “Conditioning, Kinematics, and Exchangeability” is one of the foundational documents of probability kinematics. However, the section entitled “Successive Updating” contains a subtle error regarding the applicability of updating by so-called relevance quotients in order to ensure the commutativity of successive probability kinematical revisions. Upon becoming aware of this error, Jeffrey formulated the appropriate remedy, but he never discussed the issue in print. To head off any confusion, it seems worthwhile to alert readers of Jeffrey’s “Conditioning, Kinematics, and Exchangeability” to the aforementioned error and to document his remedy, placing it in the context of both earlier and subsequent work on commuting probability kinematical revisions.1
Battling the Hydra: the disparate impact of voter ID requirements in North Dakota
Authors: Barreto Matt A. , Sanchez Gabriel R. , Walker Hannah L.
Published: February 2022

Minority voters have experienced a renewed effort to curtail their access to the ballot box in recent years. Although a host of research has examined the impact of election changes on Black and Latino voters, scholars have dedicated much less attention to the rights of Native Americans, even as they face challenges to voting in states where they comprise a significant portion of the population. Many of these states are likewise increasingly important to national elections. Such laws may impact Native Americans when they intersect with the political geography of living on a reservation, and voting rights advocates have challenged them in places like Montana, Nevada and North Dakota. This paper empirically evaluates how such laws might uniquely impact Native American voters. We draw on North Dakota's voter identification law as a case study, but our analysis has wider implications, since residency is the primary means by which election administration uniquely impacts this group. Drawing on two rich survey datasets collected in 2015 and 2017, we offer descriptive evidence of the barriers individuals may encounter while trying to obtain an ID under North Dakota's law, and find that Native Americans are statistically less likely to have access to an ID than are whites. This gap is largely due to the requirement that an ID has a physical address and attendant difficulties in obtaining such an ID, given the remote nature of reservations. We bring needed attention to the impact of carefully crafted electoral rules on this often-overlooked group.
Location, Location, Location: How Electoral Opportunities Shape Women's Emergence as Candidates
Authors: Ondercin Heather L.
Published: February 2022

Despite evidence that women win when they run for office, the number of women in the US House of Representatives has not increased substantially. I argue that women win when they run because women engage in strategic behavior by emerging in locations where they are most likely to win. While strategic behavior is a necessary condition for increasing women's representation in office, it is not a sufficient condition. Analyzing regularly scheduled elections between 1992 and 2014, I demonstrate that women engage in strategic behavior by emerging in elections where they are most likely to win. However, the electoral opportunities for women are far from “gender neutral” and are shaped by the parties. Democratic and Republican women are most likely to emerge as candidates in districts where they are likely to win the primary and general elections; however, Republican women face even more constrained electoral opportunities.
Field observations of surface ruptures accompanying a tsunami and supershear earthquake along a plate boundary strike-slip fault
Authors: Li Chuanyou , Liu Jinrui , Ma Jun , Su Gang , Lan Jian , Li Xinnan , Ren Zhikun , Ran Hongliu
Published: February 2022

Strike-slip earthquakes near major subduction zones have received less attention than thrust or reverse earthquakes in subduction zone areas. The occurrence of the 2018 Palu Mw 7.5 earthquake in eastern Indonesia provides an unprecedented opportunity to investigate the characteristics of one of these events. The Palu earthquake occurred on the left-lateral, north–south-striking Palu–Koro fault, which is the main plate boundary structure accommodating the convergence between blocks in a triple junction area. It excited a significant tsunami, which unusually is associated with strike-slip earthquakes, and also ruptured at a supershear speed, which is mostly observed on strike-slip faults in continents. Based on our fieldwork, we speculate that the normal slip component of the offshore rupture section in Palu bay on the middle segment probably favours tsunami genesis. Our field investigation has revealed evidence of a simple geometry as well as slip partitioning of dip-slip and strike-slip motion on two subparallel strands on the main segment, both of which may have contributed to the supershear of the rupture propagation. Instead of only a transtensive behaviour of the middle segment, our results also illustrate the transpressional property of the northern and southern rupture segments, which shows more complex behaviour than that of a common continental strike-slip fault.
“I Take the Pictures as I See Them”: Doris Derby as Womanist, Activist and Photographer in the Civil Rights Movement
Authors: BRADY EMILY
Published: February 2022

Doris Derby's photographic archive offers a powerful perspective on the civil rights movement that has yet to be critically or academically engaged with. Derby, an activist, photographer, and educator who has appeared in such texts as Hands on the Freedom Plow (2010) and in such collections as Julian Cox's Road to Freedom (2008), is a gateway figure to a richer, more nuanced visual history of the movement. This article utilizes original interviews, archival material, and a survey of secondary literature to call for increased consideration for Doris Derby's work. Derby's womanist perspective challenges the dominant visual rhetoric of the movement and advocates for increased consideration of the everyday activism of African American women. Men, women and children – but especially African American women – are presented in Derby's lens as dynamic agents of change. Derby's work challenges the dominant canon of the movement, which frequently relies on charismatic male leadership and black victimization. Instead, considering Derby's photography broadens our understanding of what everyday resistance in the civil rights movement was like for thousands of African Americans.
Effectiveness and optimal duration of early intervention treatment in adult-onset psychosis: a randomized clinical trial
Authors: Hui Christy Lai Ming , Wong Andreas Kar Hin , Ho Elise Chun Ning , Lam Bertha Sze Ting , Hui Priscilla Wing Man , Tao Tiffany Junchen , Chang Wing Chung , Chan Sherry Kit Wa , Lee Edwin Ho Ming , Suen Yi Nam , Lam May Mei Ling , Chiu Cindy Pui Yu , Li Frendi Wing Sai , Leung Kwok Fai , McGhee Sarah M. , Law Chi Wing , Chung Dicky Wai Sau , Yeung Wai Song , Yiu Michael Gar Chung , Pang Edwin Pui Fai , Tso Steve , Lui Simon Sai Yu , Hung Se Fong , Lee Wing King , Yip Ka Chee , Kwan Ka Lik , Ng Roger Man Kin , Sham Pak Chung , Honer William G. , Chen Eric Yu Hai
Published: February 2022

Background

Contrasting the well-described effects of early intervention (EI) services for youth-onset psychosis, the potential benefits of the intervention for adult-onset psychosis are uncertain. This paper aims to examine the effectiveness of EI on functioning and symptomatic improvement in adult-onset psychosis, and the optimal duration of the intervention.

Methods

360 psychosis patients aged 26–55 years were randomized to receive either standard care (SC, n = 120), or case management for two (2-year EI, n = 120) or 4 years (4-year EI, n = 120) in a 4-year rater-masked, parallel-group, superiority, randomized controlled trial of treatment effectiveness (Clinicaltrials.gov: NCT00919620). Primary (i.e. social and occupational functioning) and secondary outcomes (i.e. positive and negative symptoms, and quality of life) were assessed at baseline, 6-month, and yearly for 4 years.

Results

Compared with SC, patients with 4-year EI had better Role Functioning Scale (RFS) immediate [interaction estimate = 0.008, 95% confidence interval (CI) = 0.001–0.014, p = 0.02] and extended social network (interaction estimate = 0.011, 95% CI = 0.004–0.018, p = 0.003) scores. Specifically, these improvements were observed in the first 2 years. Compared with the 2-year EI group, the 4-year EI group had better RFS total (p = 0.01), immediate (p = 0.01), and extended social network (p = 0.05) scores at the fourth year. Meanwhile, the 4-year (p = 0.02) and 2-year EI (p = 0.004) group had less severe symptoms than the SC group at the first year.

Conclusions

Specialized EI treatment for psychosis patients aged 26–55 should be provided for at least the initial 2 years of illness. Further treatment up to 4 years confers little benefits in this age range over the course of the study.
Provisional boundaries and alternative solutions to maritime delimitation
Authors: Árnadóttir Snjólaug
Published: February 2022

This article is a rejoinder to Dr. Massimo Lando’s ‘Stability of maritime boundaries and the challenge of geographical change’ which proposes that positive international law offers no legal basis for the delimitation of fluctuating boundaries and discusses the many complexities involved in the delimitation and management of such boundaries. This rejoinder delves deeper into the main point of contention: the legal basis for fluctuating boundaries. It argues that coastal states have an inherent entitlement to a territorial sea and that Article 15 of The United Nations Convention on the Law of the Sea (UNCLOS) entails a default rule for the establishment of provisional fluctuating boundaries. This limit is not necessarily a strict median line because it may be adjusted by reference to special circumstances. Furthermore, the lack of explicit reference to provisional arrangements in UNCLOS Article 15 should not be read as an indication that there are no provisional boundaries in the absence of boundary agreements.

This article further argues that there are judicial precedents for fluctuating boundary-segments. The Nicaragua v. Honduras decision left a segment of the territorial sea un-delimited, resulting in a partially fluctuating boundary, until otherwise agreed. Moreover, the International Court of Justice (ICJ) explicitly established a mobile boundary-segment in Costa Rica v. Nicaragua but as highlighted by Dr. Lando, this was done with the permission of the parties. Much depends on the claims brought by disputing parties and their stance on fluctuating boundaries but this decision demonstrated the ICJ’s willingness to employ fluctuating boundaries in response to coastal instability.
REREADING METAPHYSICS Ε2-3: ARISTOTLE'S ARGUMENT AGAINST DETERMINISM, AND HOW AVERROES TWISTED IT IN HIS LONG COMMENTARY
Authors: Klinger Dustin
Published: February 2022

In the fresh reading proposed here of the still not satisfactorily interpreted passages in Metaphysics Ε2-3, Aristotle emerges as making a case against determinism based on a robust notion of the accident. Accidental beings are uncaused causes and have their rightful place in Aristotle's ontology. The resulting physical indeterminism is here used as a litmus test for the exegetical practice of the great Commentator, Averroes, whose self-proclaimed, and later proverbial, loyalty to Aristotle's text will be shown to give way to idiosyncratic interpretations at times. His explanations of Metaphysics Ε2-3 are sparse and no less obscure than Aristotle's text. It is only when read together with his commentaries on the Physics, to which he explicitly refers twice in his Long commentary on Metaphysics Ε2-3, that a surprising picture emerges. Averroes recycles the notion of the accident, now reconceptualised in cosmological terms, and – putting it to the opposite use of Aristotle's – weaves it into an original theory of motion that integrates both supra- and sublunar realms into a deterministic framework of uninterrupted causal chains, thus safeguarding the principle of Divine providence.
Making relationships: interpreting the dialogical field of an architectural project as a design object
Authors: Kenniff Thomas-Bernard
Published: February 2022

In This Is What We Do: A Muf Manual, the partners of the firm muf architecture/art wrote that ‘paradoxically, in order to make the thing the collaboration has to be about the making of the relationship rather than the object.’1 This article takes this assertion as its basis and examines the implications of treating the individual and collective relationships that structure an architectural project – which I will refer to as the project’s relational field – as a site that can be manipulated in order to affect both production and outcome. This is achieved through the transposition of concepts from Mikhail Bakhtin’s work on creative activity, art, literature, and language to design using a case study of muf’s Barking Town Square project in London (2004–10).
Non-citizen voting rights and political participation of citizens: evidence from Switzerland
Authors: Kayran Elif Naz , Nadler Anna-Lena
Published: February 2022

Can non-citizen enfranchisement policies reduce the turnout gap between citizens with an immigration background and native citizen voters? While increasingly common in practice, there are only a handful of studies on the political consequences of non-citizen enfranchisement on voter mobilisation. Here, we examine the impact of non-citizen voting (NCV) rights on the political participation of citizens with and without an immigration background. Focusing on Switzerland, we use high-quality household panel data (SHP) from 1999 to 2014, leveraging both longitudinal and municipal level variation of enfranchisement laws when identifying their effect on turnout. We show that NCV rights boost political participation overall, and it particularly enhances turnout among citizens with an immigration background. Our analysis adds to existing theoretical explanations and empirical debates on representation and political participation in diverse democratic societies with large immigrant populations.
Australian Coastal Flooding Trends and Forcing Factors
Authors: Hague Ben S. , Jones David A. , Jakob Doerte , McGregor Shayne , Reef Ruth
Published: February 2022

Using the new Australian National Collection of Homogenized Observations of Relative Sea Level (ANCHORS) dataset, we assess trends in Australian relative sea levels over recent decades and subsequent coastal flooding impacts. We estimate a gauge average rate of mean sea level rise over the 1966–2019 period of 1.94 mm/yr with local variations around the Australian continent. Simultaneously, the frequency of coastal flooding impacts has increased at many major Australian cities including Sydney, Melbourne, Brisbane, Adelaide, and Perth. We find that this increase is not because storm surges are getting larger or more frequent, but because tides are reaching higher levels as they rise and fall about higher mean sea levels. This demonstrates that a major shift in the processes that lead to coastal flooding is underway, arising directly from global mean sea level rise, and is consistent with findings from the United States. This suggests that new perspectives on extreme sea levels are required, so research can be more impact‐based and meet the needs of policymakers planning for these impacts. Considering extreme sea levels more broadly, we show that the seasonality of extreme sea levels is closely linked to the monthly variability in the heights of the highest tides. This framework provides a holistic assessment of coastal flood risk in Australia, based on established impact‐based methodologies.
Downward Oxidant Transport Through Europa's Ice Shell by Density‐Driven Brine Percolation
Authors: Hesse Marc A. , Jordan Jacob S. , Vance Steven D. , Oza Apurva V.
Published: February 2022

Jupiter's moon Europa is thought to have an ocean beneath its ice shell and the habitability of the internal ocean depends on the availability of redox gradients. Downward transport of radiolytic materials produced at the surface through the ice shell sets the flux of oxidants into the ocean. Here, we propose that oxidants are transported through the ice shell by the drainage of near‐surface brines formed concurrently with chaotic terrains. We estimate that Europa's porous regolith contains 3.7 × 1014 to 5.6 × 1018 mol (1.2 × 1013 − 1.8 × 1017 kg) of trapped O2. Simulations of coupled melt‐migration and eutectic phase behavior show that brines drain before they refreeze, delivering ∼85% of the surface oxidants to the ocean on timescales of 2 × 104 years. From the distribution of chaotic terrains and from Europa's surface age we estimate that brine drainage could deliver O2  to the ocean at rates of 2.0 × 106 to 1.3 × 1010 mol/yr (0.002−13.2 kg/s).
Free Energies of Fe‐O‐Si Ternary Liquids at High Temperatures and Pressures: Implications for the Evolution of the Earth's Core Composition
Authors: Zhang Zhigang , Csányi Gábor , Alfè Dario , Zhang Yigang , Li Juan , Liu Jin
Published: February 2022

Solubility of oxygen and silicon in the iron‐alloying liquids is important for constraining the core composition over the Earth's history. In this study, we systematically simulated the free energies of Fe‐O‐Si ternary liquids from 3000 K, 55 GPa to 6000 K, and 330 GPa. We found that temperature and pressure have remarkable influences on the free energies, and the nonideality of mixing is important for the chemical potentials even at high temperatures. Equilibrating with SiO2 phase, Fe‐O‐Si liquids significantly enhance the solubility of Si and O simultaneously with increasing temperature. Considering the secular cooling of the Earth's core, this leads to high precipitation rates of SiO2 once it was saturated, which would efficiently drive ancient geodynamo. If the evolution of Earth's core started from an oxygen‐poor composition, later incorporations of oxygen seem to be needed to reach a core composition compatible with geophysical observations.
Functional Multi‐Scale Integration of Agricultural Nitrogen‐Budgets Into Catchment Water Quality Modeling
Authors: Yang Xiaoqiang , Rode Michael , Jomaa Seifeddine , Merbach Ines , Tetzlaff Doerthe , Soulsby Chris , Borchardt Dietrich
Published: February 2022

Diffuse Nitrogen pollution from agriculture maintains high pressures on groundwater and aquatic ecosystems. Further mitigation requires targeted measures that reconcile agricultural interests in environmental protection. However, the agriculture‐related processes of catchment N modeling remain poorly defined due to discipline‐specific data and knowledge gaps. Using field‐experimental data, crop N uptake responses to fertilizer management were parsimoniously conceptualized and integrated into a catchment diffuse‐N model. The improved catchment modeling further facilitated integration with agricultural budget‐based assessments. The integrated analysis in a mesoscale catchment disentangled contrasting agri‐environment functional mechanisms in typically flashy chemodynamic and transport‐limited chemostatic export regimes. Moreover, the former was actively responsive to interannual climatic variability and agricultural practices; the latter exhibited drought‐induced enhancement of N enrichment, which could likely be mitigated through reduced fertilization. This interdisciplinary integration of data and methods provided an insightful evidence base for multi‐sector targeted measures, especially under cumulative impacts of changing climate and fertilizer‐use intensities.
Limited Lateral Transport Bias During Export of Sea Surface Temperature Proxy Carriers in the Mediterranean Sea
Authors: Rice Addison , Nooteboom Peter D. , van Sebille Erik , Peterse Francien , Ziegler Martin , Sluijs Appy
Published: February 2022

Some lipid‐biomarker‐based sea surface temperature (SST) proxies applied in the modern Mediterranean Sea exhibit large offsets from expected values, generating uncertainties in climate reconstructions. Lateral transport of proxy carriers along ocean currents prior to burial can contribute to this offset between reconstructed and expected SSTs. We perform virtual particle tracking experiments to simulate transport prior to and during sinking and derive a quantitative estimate of transport bias for alkenones and glycerol dibiphytanyl glycerol tetraethers (GDGTs), which form the basis of the UK’37 and TEX86 paleothermometers, respectively. We use a simple 30‐day surface advection scenario and sinking speeds appropriate for the export of various proxy carriers (6, 12, 25, 50, 100, 250, 500, and 1000 md−1). For the assessed scenarios, lateral transport bias is generally small (always <0.85°C) within the Mediterranean Sea and does not substantially contribute to uncertainties in UK’37‐ or TEX86‐based SSTs.
The Three Rs: Resolving Respiration Robotically in Shelf Seas
Authors: Williams C. A. J. , Davis C. E. , Palmer M. R. , Sharples J. , Mahaffey C.
Published: February 2022

Ocean deoxygenation threatens ocean productivity, carbon cycling and marine ecosystems. Shelf seas are highly dynamic regions, which contributes to their high productivity and also makes monitoring and constraining their oxygen status a challenge. Here, using the temperate Celtic shelf sea (April and July 2015) as a case study, we present high‐resolution ocean glider observations of turbulence and biogeochemical parameters, demonstrating the potential of these autonomous platforms for environmental monitoring. We estimate vertical turbulent oxygen fluxes be 25% higher in summer than in spring, due to the presence of subsurface chlorophyll and associated oxygen maxima at the seasonal thermocline. We demonstrate that glider‐based estimates were able to constrain similar bottom layer respiration rates as those derived from traditional ship‐based measurements. We suggest ocean gliders are useful monitoring tools that can aid sustainable management of shelf sea ecosystems.
GPS‐Observed Elastic Deformation Due to Surface Mass Balance Variability in the Southern Antarctic Peninsula
Authors: Koulali Achraf , Whitehouse Pippa L. , Clarke Peter J. , van den Broeke Michiel R. , Nield Grace A. , King Matt A. , Bentley Michael J. , Wouters Bert , Wilson Terry
Published: February 2022

In Antarctica, Global Positioning System (GPS) vertical time series exhibit non‐linear signals over a wide range of temporal scales. To explain these non‐linearities, a number of hypotheses have been proposed, among them the short‐term rapid solid Earth response to contemporaneous ice mass change. Here we use GPS vertical time series to reveal the solid Earth response to variations in surface mass balance (SMB) in the Southern Antarctic Peninsula (SAP). At four locations in the SAP we show that interannual variations of SMB anomalies cause measurable elastic deformation. We use regional climate model SMB products to calculate the induced displacement assuming a perfectly elastic Earth. Our results show a reduction of the misfit when fitting a linear trend to GPS time series corrected for the elastic response to SMB variations. Our results imply that, for a better understanding of the glacial isostatic adjustment signal in Antarctica, SMB variability must be considered.
Addendum to “Quantifying Uncertainty in Tracer‐Based Hydrograph Separations” for Three‐Component Mixing Problems
Authors: Genereux David P.
Published: February 2022

Water mixing problems are common in hydrology. A 1998 paper describing uncertainty analysis in tracer‐based mixing problems is widely cited but does not present the equations needed for three‐component problems. This Commentary presents the equations needed to compute the uncertainties in the mixing fractions for a three‐component water mixing problem based on tracer data.
UGT1A1 genetic variants are associated with increases in bilirubin levels in rheumatoid arthritis patients treated with sarilumab
Authors: Lin Nan , Damask Amy , Boyapati Anita , Hamilton Jennifer D. , Hamon Sara , Ternes Nils , Nivens Michael C. , Penn John , Lopez Alexander , Reid Jeffrey G. , Overton John , Shuldiner Alan R. , Abecasis Goncalo , Baras Aris , Paulding Charles
Published: February 2022

Sarilumab is a human monoclonal antibody against interleukin (IL)-6Rα that has been approved for the treatment of adult patients with moderately to severely active rheumatoid arthritis (RA) and an inadequate response or intolerance to one or more disease-modifying antirheumatic drugs (DMARDs). Mild liver function test abnormalities have been observed in patients treated with sarilumab. We describe a genome-wide association study of bilirubin elevations in RA patients treated with sarilumab. Array genotyping and exome sequencing were performed on DNA samples from 1075 patients. Variants in the UGT1A1 gene were strongly associated with maximum bilirubin elevations in sarilumab-treated patients (rs4148325; p = 2.88 × 10−41) but were not associated with aminotransferase elevations. No other independent loci showed evidence of association with bilirubin elevations after sarilumab treatment. These findings suggest that most bilirubin increases during sarilumab treatment are related to genetic variation in UGT1A1 rather than underlying liver injury.
IκB-ζ signaling promotes chondrocyte inflammatory phenotype, senescence, and erosive joint pathology
Authors: Arra Manoj , Swarnkar Gaurav , Alippe Yael , Mbalaviele Gabriel , Abu-Amer Yousef
Published: February 2022

Osteoarthritis is a joint disease characterized by a poorly-defined inflammatory response that does not encompass a massive immune cell infiltration yet contributes to cartilage degradation and loss of joint mobility, suggesting a chondrocyte intrinsic inflammatory response. Using primary chondrocytes from joints of osteoarthritic mice and patients, we first show that these cells express ample pro-inflammatory markers and RANKL in an NF-κB dependent manner. The inflammatory phenotype of chondrocytes was recapitulated by exposure of chondrocytes to IL-1β and bone particles, which were used to model bone matrix breakdown products revealed to be present in synovial fluid of OA patients, albeit their role was not defined. We further show that bone particles and IL-1β can promote senescent and apoptotic changes in primary chondrocytes due to oxidative stress from various cellular sources such as the mitochondria. Finally, we provide evidence that inflammation, oxidative stress and senescence converge upon IκB-ζ, the principal mediator downstream of NF-κB, which regulates expression of RANKL, inflammatory, catabolic, and SASP genes. Overall, this work highlights the capacity and mechanisms by which inflammatory cues, primarily joint degradation products, i.e., bone matrix particles in concert with IL-1β in the joint microenvironment, program chondrocytes into an “inflammatory phenotype” which inflects local tissue damage.
Long non-coding RNA SNHG10 upregulates BIN1 to suppress the tumorigenesis and epithelial–mesenchymal transition of epithelial ovarian cancer via sponging miR-200a-3p
Authors: Lv Wei , Jia Yunlong , Wang Jiali , Duan Yuqing , Wang Xuexiao , Liu Tianxu , Hao Shuwei , Liu Lihua
Published: February 2022

Epithelial ovarian cancer (EOC) is one of the most frequent and fatal gynecologic malignant tumors resulting in an unsatisfying prognosis. Long non-coding RNAs (lncRNAs) play pivotal roles in the tumorigenesis and progression of EOC. However, the profile of lncRNAs involved in EOC remains to be expanded to further improve clinical treatment strategy. In present study, we identified a novel tumor-suppressive lncRNA small nucleolar RNA host gene 10 (SNHG10) in EOC. Kaplan–Meier analysis and COX proportional hazard progression model showed that low expression of SNHG10 was correlated with a poor prognosis of EOC patients. Overexpressing SNHG10 suppressed the proliferation, colony formation, migration, and invasion of EOC cells. Furthermore, SNHG10 was predicted to sponge miR-200a-3p in EOC cells according to the LncBase v.2 experimental module. Then, the binding of SNHG10 and miR-200a-3p was confirmed by performing quantitative real-time PCR (qRT-PCR) and luciferase reporter assays. RNA immunoprecipitation (RIP) showed that SNHG10 and miR-200a-3p occupied the same Ago2 protein to form an RNA-induced silencing complex (RISC). By overlapping the results from the bioinformatics algorithms, tumor-suppressor bridging integrator-1 (BIN1) was found to be a main downstream target of the SNHG10/miR-200a-3p axis. Low expression of BIN1 in EOC tissues was detected by using immunohistochemistry (IHC). Besides, BIN1 and SNHG10 expression was positively correlated in EOC tissues. By performing miRNA rescue experiments, a SNHG10/miR-200a-3p/BIN1 axis and its promoting effects on malignant behaviors and epithelial–mesenchymal transition (EMT) process were verified in EOC cells. Moreover, SNHG10 overexpression significantly suppressed the tumorigenesis and EMT of EOC cells in vivo. Altogether, SNHG10 sponges miR-200a-3p to upregulate BIN1 and thereby exerting its tumor-suppressive effects in EOC. Therefore, the SNHG10/miR-200a-3p/BIN1 axis may act as a potential predictive biomarker and therapeutic target for treating EOC.
Telomerase is required for glomerular renewal in kidneys of adult mice
Authors: Montandon Margo , Hamidouche Tynhinane , Yart Lucile , Duret Lou C. , Pons Catherine , Soubeiran Nicolas , Pousse Mélanie , Cervera Ludovic , Vial Valérie , Fassy Julien , Croce Olivier , Gilson Eric , Shkreli Marina
Published: February 2022

Homeostatic renal filtration relies on the integrity of podocytes, which function in glomerular filtration. These highly specialized cells are damaged in 90% of chronic kidney disease, representing the leading cause of end-stage renal failure. Although modest podocyte renewal has been documented in adult mice, the mechanisms regulating this process remain largely unknown and controversial. Using a mouse model of Adriamycin-induced nephropathy, we find that the recovery of filtration function requires up-regulation of the endogenous telomerase component TERT. Previous work has shown that transient overexpression of catalytically inactive TERT (i-TERTci mouse model) has an unexpected role in triggering dramatic podocyte proliferation and renewal. We therefore used this model to conduct specific and stochastic lineage-tracing strategies in combination with high throughput sequencing methods. These experiments provide evidence that TERT drives the activation and clonal expansion of podocyte progenitor cells. Our findings demonstrate that the adult kidney bears intrinsic regenerative capabilities involving the protein component of telomerase, paving the way for innovative research toward the development of chronic kidney disease therapeutics.
Comprehensive assessment of systemic arteriosclerosis in relation to the ocular resistive index in acute coronary syndrome patients
Authors: Ebuchi Yasunari , Nagaoka Taiji , Fukamachi Daisuke , Kojima Keisuke , Akutsu Naotaka , Murata Nobuhiro , Saito Yuki , Kitano Daisuke , Yokota Harumasa , Yamagami Satoru , Okumura Yasuo
Published: February 2022

This study aimed to investigate the relationship between ocular vascular resistance parameters, evaluated by laser speckle flowgraphy (LSFG), and systemic atherosclerosis, renal parameters and cardiac function in acute coronary syndrome (ACS) patients. We evaluated 53 ACS patients between April 2019 and September 2020. LSFG measured the mean blur rate (MBR) and ocular blowout time (BOT) and resistivity index (RI). 110 consequent patients without a history of coronary artery disease who visited ophthalmology as a control group. Significant positive correlations were observed between ocular RI and systemic parameters in ACS patients, including intima-media thickness (r = 0.34, P = 0.015), brachial-ankle pulse-wave velocity (r = 0.41, P = 0.002), cystatin C (r = 0.32, P = 0.020), and E/e’ (r = 0.34, P = 0.013). Ocular RI was significantly higher in the ACS group than in the control group in male in their 40 s (0.37 ± 0.02 vs. 0.29 ± 0.01, P < 0.001) and 50 s (0.36 ± 0.02 vs. 0.30 ± 0.01, P = 0.01). We found that the ocular RI was associated with systemic atherosclerosis, early renal dysfunction, and diastolic cardiac dysfunction in ACS patients, suggesting that it could be a useful non-invasive comprehensive arteriosclerotic marker.