bluuebunny/crossref_metadata_2025 huggingface dataset:
JNK inhibitor and ferroptosis modulator as possible therapeutic modalities in Alzheimer disease (AD)
Authors: Zakaria Sherin , Ibrahim Nashwa , Abdo Walied , E. El-Sisi Alaa
Published: October 2024

Alzheimer disease (AD) is among the most prevalent neurodegenerative diseases globally, marked by cognitive and behavioral disruptions. Ferroptosis is a form of controlled cell death characterized by intracellular iron accumulation associated with lipid peroxide formation, which subsequently promotes AD initiation and progression. We hypothesized that targeting the ferroptosis pathway may help in AD management. Therefore, our study aimed to evaluate the potential neuroprotective effect of the antifungal Ciclopirox olamine (CPX-O) that acts through iron chelation. We employed CPX-O separately or in combination with the JNK inhibitor (SP600125) in a mice model of AlCl3-induced AD. Animals underwent examination for behavioral, biochemical, histological, and immunohistochemical findings. Our results revealed that AlCl3 was associated with disruptions in learning and memory parameters, neuronal degeneration in the hippocampus, increased immunoreactivity of amyloid-β and tau proteins, a significant rise in iron, nitric oxide (NO), malondialdehyde (MDA), JNK, and P53 levels, along with the significant decrease in glutathione peroxidase activity. Interestingly, the administration of CPX-O alone or in combination with SP600125 in the AlCl3-induced AD model caused an improvement in the previously described examination findings. Therefore, CPX-O may be a promising candidate for AD treatment, and future clinical trials will be required to confirm these preclinical findings.
Benthic remineralization under future Arctic conditions and evaluating the potential for changes in carbon sequestration in warming sediments
Authors: Sen Arunima , Molina Eric Jordà , de Freitas Thaise Ricardo , Hess Silvia , Reiss Henning , Bluhm Bodil A. , Renaud Paul E.
Published: October 2024

Benthic (seafloor) remineralization of organic material determines the fate of carbon in the ocean and its sequestration. Bottom water temperature and labile carbon supply to the seafloor are expected to increase in a warming Arctic and correspondingly, benthic remineralization rates. We provide some of the first experimental data on the response of sediment oxygen demand (SOD), an established proxy for benthic remineralization, to increased temperature and/or food supply across a range of Arctic conditions and regimes. Each factor significantly increased SOD rates (with different degrees of variability); however the largest increases were seen with both factors combined (50% to ten-fold increases), consistently across the four seasons and the spatial gradient covering shelf to deep basin included in our study. This ability of the Arctic benthos to process increased pulses of carbon suggests that increased sedimented carbon under warming conditions is likely to be utilized and processed, not accumulated, impacting carbon storage and decreasing the Arctic’s role as a global carbon sink.
Identifying patient subgroups in MASLD and MASH-associated fibrosis: molecular profiles and implications for drug development
Authors: González Hernández Manuel A. , Verschuren Lars , Caspers Martien P.M. , Morrison Martine C. , Venhorst Jennifer , van den Berg Jelle T. , Coornaert Beatrice , Hanemaaijer Roeland , van Westen Gerard J. P.
Published: October 2024

The incidence of MASLD and MASH-associated fibrosis is rapidly increasing worldwide. Drug therapy is hampered by large patient variability and partial representation of human MASH fibrosis in preclinical models. Here, we investigated the mechanisms underlying patient heterogeneity using a discovery dataset and validated in distinct human transcriptomic datasets, to improve patient stratification and translation into subgroup specific patterns. Patient stratification was performed using weighted gene co-expression network analysis (WGCNA) in a large public transcriptomic discovery dataset (n = 216). Differential expression analysis was performed using DESeq2 to obtain differentially expressed genes (DEGs). Ingenuity Pathway analysis was used for functional annotation. The discovery dataset showed relevant fibrosis-related mechanisms representative of disease heterogeneity. Biological complexity embedded in genes signature was used to stratify discovery dataset into six subgroups of various sizes. Of note, subgroup-specific DEGs show differences in directionality in canonical pathways (e.g. Collagen biosynthesis, cytokine signaling) across subgroups. Finally, a multiclass classification model was trained and validated in two datasets. In summary, our work shows a potential alternative for patient population stratification based on heterogeneity in MASLD-MASH mechanisms. Future research is warranted to further characterize patient subgroups and identify protein targets for virtual screening and/or in vitro validation in preclinical models.
Differential gene expression in neonatal calf muscle tissues from Hanwoo cows overfed during mid to late pregnancy period
Authors: Shokrollahi Borhan , Park Myungsun , Baek Youl-Chang , Jin Shil , Jang Gi-Suk , Moon Sung-Jin , Um Kyung-Hwan , Jang Sun-Sik , Lee Hyun-Jeong
Published: October 2024

Maternal nutrition significantly influences fetal development and postnatal outcomes. This study investigates the impact of maternal overfeeding during mid to late pregnancy on gene expression in the round and sirloin muscles of Hanwoo neonatal calves. Eight cows were assigned to either a control group receiving standard nutrition (100%) or a treated group receiving overnutrition (150%). After birth, tissue samples from the round and sirloin muscles of neonatal calves were collected and subjected to RNA sequencing to assess differentially expressed genes (DEGs). RNA sequencing identified 43 DEGs in round muscle and 15 in sirloin muscle, involving genes related to myogenesis, adipogenesis, and energy regulation. Key genes, including PPARGC1A, THBS1, CD44, JUND, CNN1, ENAH, and RUNX1, were predominantly downregulated. Gene ontology (GO) enrichment analyses revealed terms associated with muscle development, such as “biological regulation,” “cellular process,” and “response to stimulus.” Protein-protein interaction networks highlighted complex interactions among DEGs. Random Forest analysis identified ARC, SLC1A5, and GNPTAB as influential genes for distinguishing between control and treated groups. Overall, maternal overnutrition during mid-to-late pregnancy results in the downregulation of genes involved in muscle development and energy metabolism in neonatal Hanwoo calves. These findings provide insights into the molecular effects of maternal nutrition on muscle development.
Statistics design for the synthesis optimization of lignin-sulfonate sulfur-doped mesoporous carbon materials: promising candidates as adsorbents and supercapacitors materials
Authors: dos Reis Glaydson Simoes , Petnikota Shaikshavali , de Oliveira Helinando Pequeno , de Brum Irineu A.S. , Thyrel Mikael , Dotto Guiherme Luiz , Lima Eder Claudio , Naushad Mu. , Hu Tao , Lassi Ulla , Grimm Alejandro
Published: October 2024

This study employed lignin-sulfonated (LS) to develop biobased carbon materials (LS-Cs) through a sulfur-doping approach to enhance their physicochemical properties, adsorption capabilities, and energy storage potentials. Various characterization techniques, including BET surface area analysis, SEM imaging, XPS, Raman spectroscopy, and elemental composition (CHNS), were employed to assess the quality of the LS-Cs adsorbent and electrode samples. Response Surface Methodology (RSM) was utilized for optimizing the two main properties (specific surface area, ABET, and mesopore area, AMESO) by evaluating three independent factors (i.e., activation temperature, ZnCl2:LS ratio, and sulfur content). According to the statistical analysis, ABET and AMESO were affected by ZnCl2 and sulfur content, while the pyrolysis temperature did not affect the responses in the studied conditions. It was found that increasing the ZnCl2 and sulfur contents led to an increment of the ABET and AMESO values. The LS-C materials exhibited very high ABETvalues up to 1993 m2 g−1 and with predominantly mesoporous features. The S-doping resulted in LS-Cs with high sulfur contents in their microstructures up to 15% (wt%). The LS-C materials were tested as adsorbents for sodium diclofenac (DCF) adsorption and reactive orange 16 dye (RO-16) and as electrodes for supercapacitors. The LS-Cs exhibited excellent adsorption capacity values for both molecules (197–372 mg g−1) for DCF, and (223–466 mg g−1) for RO-16. When tested as electrodes for supercapacitors, notably, LS-C3, which is a doped sample with sulfur, exhibited the best electrochemical performance, e.g. high specific capacitance (156 F/g at 50 mV/s), and delivered an excellent capacitance after 1000 cycles (63 F/g at 1 A/g), which denotes the noteworthy capacitive behavior of the S-doped electrode. Thus, the present work suggests an eco-friendly resource for developing effective, productive carbon materials for adsorbent and electrodes for SC application. However, further studies on the complete application of these materials as adsorbents and electrodes are needed for a deeper understanding of their behavior in environmental and energy storage applications.
Calcium wave dynamics in the embryonic mouse gut mesenchyme: impact on smooth muscle differentiation
Authors: Chevalier Nicolas R. , Zig Léna , Gomis Anthony , Amedzrovi Agbesi Richard J. , El Merhie Amira , Pontoizeau Laetitia , Le Parco Isabelle , Rouach Nathalie , Arnoux Isabelle , de Santa Barbara Pascal , Faure Sandrine
Published: October 2024

Intestinal smooth muscle differentiation is a complex physico-biological process involving several different pathways. Here, we investigate the properties of Ca2+ waves in the developing intestinal mesenchyme using GCamp6f expressing mouse embryos and investigate their relationship with smooth muscle differentiation. We find that Ca2+ waves are absent in the pre-differentiation mesenchyme and start propagating immediately following α-SMA expression. Ca2+ waves are abrogated by CaV1.2 and gap-junction blockers, but are independent of the Rho pathway. The myosine light-chain kinase inhibitor ML-7 strongly disorganized or abolished Ca2+ waves, showing that perturbation of the contractile machinery at the myosine level also affected the upstream Ca2+ handling chain. Inhibiting Ca2+ waves and contractility with CaV1.2 blockers did not perturb circular smooth muscle differentiation at early stages. At later stages, CaV1.2 blockers abolished intestinal elongation and differentiation of the longitudinal smooth muscle, leading instead to the emergence of KIT-expressing interstitial cells of Cajal at the gut periphery. CaV1.2 blockers also drove apoptosis of already differentiated, CaV1.2-expressing smooth muscle and enteric neural cells. We provide fundamental new data on Ca2+ waves in the developing murine gut and their relation to myogenesis in this organ.
Cell stress and phase separation stabilize the monomeric state of pseudoisocyanine chloride employed as a self-assembly crowding sensor
Authors: Pollak Roland , Koch Leon , König Benedikt , Ribeiro Sara S. , Samanta Nirnay , Huber Klaus , Ebbinghaus Simon
Published: October 2024

Cellular stress and ageing involve an increase in crowding and aggregation of amylogenic proteins. We here investigate if crowding is the intrinsic cause of aggregation and utilise a previously established non-protein aggregation sensor, namely pseudoisocyanine chloride (PIC). PIC shows fibrillization in cells into a highly fluorescent J-aggregated state and is sensitive to crowding. Surprisingly, cell stress conditions stabilise the monomeric rather than the aggregated state of PIC both in the cytoplasm and in stress granules. Regarding the different physiochemical changes of the cytoplasm occurring upon cell stress, involving volume reduction, phase separation and solidification, the intrinsic crowding effect is not the key factor to drive associated self-assembly processes.
Scalable on-chip multiplexing of silicon single and double quantum dots
Authors: Bohuslavskyi Heorhii , Ronzani Alberto , Hätinen Joel , Rantala Arto , Shchepetov Andrey , Koppinen Panu , Lehtinen Janne S. , Prunnila Mika
Published: October 2024

Owing to the maturity of complementary metal oxide semiconductor (CMOS) microelectronics, qubits realized with spins in silicon quantum dots (QDs) are considered among the most promising technologies for building scalable quantum computers. For this goal, ultra-low-power on-chip cryogenic CMOS (cryo-CMOS) electronics for control, read-out, and interfacing of the qubits is an important milestone. We report on-chip interfacing of tunable electron and hole QDs by a 64-channel cryo-CMOS multiplexer with less-than-detectable static power dissipation. We analyze charge noise and measure state-of-the-art addition energies and gate lever arm parameters in the QDs. We correlate low noise in QDs and sharp turn-on characteristics in cryogenic transistors, both fabricated with the same gate stack. Finally, we demonstrate that our hybrid quantum-CMOS technology provides a route to scalable interfacing of a large number of QD devices, enabling, for example, variability analysis and QD qubit geometry optimization, which are prerequisites for building large-scale silicon-based quantum computers.
Hybrid bottom-up and top-down framework resolves discrepancies in Canada’s oil and gas methane inventories
Authors: Chan Elton , Vogel Felix , Smyth Steve , Barrigar Owen , Ishizawa Misa , Kim Jinwoong , Neish Michael , Chan Douglas , Worthy Douglas E. J.
Published: October 2024

Estimating accurate oil and gas methane emissions has been a global challenge, highlighted by a twofold discrepancy between atmospheric measurement-based estimates and emission inventories. The principle of continuous improvement in Canada’s National Inventory Report has led to an unstable baseline in recent years for tracking emission reduction progress. The gaps between previous inventory estimates and inversions exceeded 60%. Here we show that incorporating new source-resolved information derived from low-altitude aerial survey data has narrowed this gap by 80%, reducing the discrepancy to 10% for the 2010–2014 baseline. This study proposes a hybrid emission reporting framework, complemented by an ensemble inversion top-down method using continuous tower-based atmospheric measurements, to establish a stable baseline and provide independent verification. As the 2030 target year for emission reduction approaches, we report a significant 27% decline (19%–34%) in inverse oil and gas methane emissions from 2010 to 2022 in Alberta and Saskatchewan, Canada, and a 41% decline (26%–56%) as calculated using the 2024 official inventory.
A register-based cohort study on the effectiveness and Safety of anti-PCSK9 treatment in persons with hyperlipidemia
Authors: Andersen Michael Asger , Helms Andreasen Anne , Evi Bang Lia , Jimenez-Solem Espen , Petersen Tonny Studsgaard
Published: October 2024

Background

Dyslipidemia is a known risk factor for cardiovascular disease. While statins are the primary treatment, some individuals require additional lipid-lowering therapies, such as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. Alirocumab and evolocumab have shown efficacy in reducing low-density lipoprotein cholesterol (LDL-C) levels and reduce the risk of major cardiovascular events (MACE) but have not been directly compared in clinical trials. This study aims to assess the effects of PCSK9 inhibitors on LDL-C levels and evaluate the impact of a mandated switch from alirocumab to evolocumab.

Methods

Taking advantage of the mandated switch in PCSK9 treatment in Denmark, we conducted a register-based cohort study of 907 individuals with dyslipidemia treated with PCSK9 inhibitors in the Capital Region of Denmark from 2016 to 2022. We analyzed LDL-C levels, treatment retention, and MACE, adjusting for variables such as age, sex, dose, and concurrent lipid-lowering medications.

Results

We show that PCSK9 inhibitors treatment resulted in a 49% reduction in LDL-C levels. Following a mandated switch from alirocumab to evolocumab, no significant difference was observed in LDL-C levels or adverse clinical outcomes, including MACE. Treatment discontinuation was most likely within the first 100 days, and no significant difference in discontinuation rates was found between the two drugs.

Conclusions

Our study demonstrates that both alirocumab and evolocumab are effective in significantly reducing LDL-C levels in individuals with dyslipidemia. The mandated switch from alirocumab to evolocumab did not result in significant changes in LDL-C or clinical outcomes, suggesting that these treatments can be used interchangeably. These findings support the clinical equivalence of the two PCSK9 inhibitors and may guide therapeutic decisions in lipid management.
Recognition of phylogenetically diverse pathogens through enzymatically amplified recruitment of RNF213
Authors: Crespillo-Casado Ana , Pothukuchi Prathyush , Naydenova Katerina , Yip Matthew C J , Young Janet M , Boulanger Jerome , Dharamdasani Vimisha , Harper Ceara , Hammoudi Pierre-Mehdi , Otten Elsje G , Boyle Keith , Gogoi Mayuri , Malik Harmit S , Randow Felix
Published: October 2024

Innate immunity senses microbial ligands known as pathogen-associated molecular patterns (PAMPs). Except for nucleic acids, PAMPs are exceedingly taxa-specific, thus enabling pattern recognition receptors to detect cognate pathogens while ignoring others. How the E3 ubiquitin ligase RNF213 can respond to phylogenetically distant pathogens, including Gram-negative Salmonella, Gram-positive Listeria, and eukaryotic Toxoplasma, remains unknown. Here we report that the evolutionary history of RNF213 is indicative of repeated adaptation to diverse pathogen target structures, especially in and around its newly identified CBM20 carbohydrate-binding domain, which we have resolved by cryo-EM. We find that RNF213 forms coats on phylogenetically distant pathogens. ATP hydrolysis by RNF213’s dynein-like domain is essential for coat formation on all three pathogens studied as is RZ finger-mediated E3 ligase activity for bacteria. Coat formation is not diffusion-limited but instead relies on rate-limiting initiation events and subsequent cooperative incorporation of further RNF213 molecules. We conclude that RNF213 responds to evolutionarily distant pathogens through enzymatically amplified cooperative recruitment.
Mass spectrometry reflects key aspects of copper-amyloid β chemistry
Authors: Brandner Sarah , Habeck Tanja , Lermyte Frederik
Published: October 2024

[Cu(ii)-amyloid β] undergoes specific gas-phase radical chemistry that reflects formation of reactive oxygen species in vitro and in vivo. The key sequence motif is the same in solution and the gas phase, and it can be identified by native MS.
Microfluidic methods for the diagnosis of acute respiratory tract infections
Authors: Liu Kan-Zhi , Tian Ganghong , Ko Alex C.-T. , Geissler Matthias , Malic Lidija , Moon Byeong-Ui , Clime Liviu , Veres Teodor
Published: October 2024

We review emerging methods for the detection of acute respiratory tract infections using microfluidic technologies.
Double-channel sensors for high precision measurement of methane based on a dual-path Herriott cell
Authors: Ma Hongliang , Wang Shiqi , Wang Gaoxuan , Zhang Qilei , Zha Shenlong , Cai Xueyuan , Li Lingli , Pan Pan , Liu Qiang , Zhan Shengbao
Published: October 2024

A novel method combining dual-channel concentration signal averaging with detector gain optimization is proposed to improve the measurement precision and response speed of the sensor within the 1–10 second integration time.
In situ modified mesoporous silica nanoparticles: synthesis, properties and theranostic applications
Authors: Trayford Chloe , van Rijt Sabine
Published: October 2024

This review describes in situ modification of MSNs and how this effects their material properties. It highlights their application in theranostics, oncology, and regenerative medicine field, concluding with future challenges for clinical use.
Polymer-supported strong Lewis acid phosphonium cation catalysis applied to sydnone synthesis
Authors: Dol Ryan , Kovljenic Nenad , Dudding Travis
Published: October 2024

In advancing the field of pnictogen catalysis we introduce a new concept of polymer-supported phosphorus(v)-mediated Lewis acid catalysis demonstrated for the one-pot synthesis of sydnone heterocycles.
3D-printed photothermal-responsive shape-memory polymer for soft robotic applications
Authors: Ghosh Kalyan , Kar-Narayan Sohini
Published: October 2024

We report the photothermal actuation of 4D-printed tools which are SLA-printed employing a customized photocurable resin. The tools can be applied in soft robotic applications stimulated by a heat lamp at a near ambient temperature of 15–45 °C.
Progress and limitations in reactive oxygen species quantitation
Authors: Spanolios Eleni M. , Lewis Riley E. , Caldwell Rhea N. , Jilani Safia Z. , Haynes Christy L.
Published: October 2024

Reactive oxygen species (ROS) can be quantified using fluorescence, electrochemical, and electron paramagnetic resonance spectroscopy techniques. Detection of ROS is critical in a wide range of chemical and biological systems.
Controlling carbodiimide-driven reaction networks through the reversible formation of pyridine adducts
Authors: Salvia William S. , Mantel Georgia , Saha Nirob K. , Rajawasam Chamoni W. H. , Konkolewicz Dominik , Hartley C. Scott
Published: October 2024

The reversible formation of adducts between a carbodiimide and a pyridine allows the slow release of fuels for transient anhydride bond formation.
Chloride Induced S–C bond selective cleavage of disulfides to access unsymmetrical β-fluorodisulfides
Authors: Niu Tengfei , Zhang Jiayuan , He Yunpeng , Hong Mei , Zhu Lei , Lan Yu
Published: October 2024

This work describes a novel chloride anion induced radical-triggered S–C bond selective cleavage of disulfides to access unsymmetrical β-fluorodisulfides by disulfidefluorination of alkenes.
A two-dimensional coordination polymer with high laccase-like activity for sensitive colorimetric detection of thiram
Authors: Han Songxue , Xu Lili , Fang Youxing , Dong Shaojun
Published: October 2024

Two-dimensional nanosheets of a coordination polymer with a high surface area and abundant exposed active sites were developed for sensitive colorimetric detection of thiram.
A (C5Me5)/enolamido lutetium dinitrogen complex promoted by deprotonation on the amidinate ligand
Authors: Chen Xiao , Xu Hanhua , Xi Zhenfeng , Wei Junnian
Published: October 2024

Two Cp*/enolamido supported lutetium dinitrogen complexes were established through the selective deprotonation of the amidinate ligand in the Cp*/amidinate lutetium dinitrogen complex.
Metal–organic framework with pore contraction and modification by diethylammonium cations for record SO2/CO2 separation
Authors: Yang Mei , Yuan Wenke , Li Xiu-Yuan , Liu Bo , Zhou Huifang
Published: October 2024

A robust MOF, featuring diethylammonium cations, optimizes pore partitioning and alters the environment, facilitating record SO2/CO2 separation.
Boat-to-boat conformation inversions of cyclobis[7,8-(para-quinodimethane)-3,7-(9-(p-tolyl)-9H-carbazole)] in the neutral and tetracationic state
Authors: Tong Zekun , Dong Shaoqiang
Published: October 2024

Macrocycle cyclobis[7,8-(para-quinodimethane)-4,4′-(triphenylamine)] (CBQCz) shows temperature-dependent and four-electron oxidative conformation changes.
A ternary composite nanofiber-derived thin membrane electrolyte for solid-state Li metal batteries
Authors: Gong Xiaoqi , Pan Yaozheng , Zhong Linfeng , Wang Jiasheng , Liu Fujie , Qi Guangsheng , Li Jing , Liu Cong , Yu Dingshan
Published: October 2024

We develop a novel membrane electrolyte comprising h-BN-doped PEO modified PVDF-HFP-nanofibers with high ionic conductivity (3.3 × 10−4 S cm−1) and Li+ transference number (0.74), endowing solid LiFePO4//Li batteries with excellent cyclability.
Two polyoxovanadates for visible light driven photocatalytic performance
Authors: Huang Li , Yang Yufan , Yu Xiaoyang , Li Xiaonan , Shen Yuan , Song Runhong , Zhang Hong
Published: October 2024

The synthesis of the highest-nuclearity IPOV using PhPO3 as the only organic ligand.
Synergy of CuO and g-C3N4 for boosting hydrogen peroxide photosynthesis
Authors: Pang Yuqing , Tian Yan , Zheng Peng , Feng Ke , Mao Jie , Zhu Yujun , Huang Kai , Ke Fei , Zhang Chunyan
Published: October 2024

A series of CuO decorated g-C3N4 composites with suitable bandgaps for boosting photocatalytic production of H2O2.
The effect of heavy atoms on the deactivation of electronic excited states of dye molecules near the surface of metal nanoparticles
Authors: Ibrayev N. , Seliverstova E. , Valiev R. , Aymagambetova A. , Sundholm D.
Published: October 2024

The influence of a heavy atom and the plasmon on the efficiency of triplet state (T1) and on the phosphorescence has been studied for fluorescein and its derivatives.
Electric-field-induced structure and dynamics of an ethanol–water mixture in hydrophobic–hydrophilic nanochannels
Authors: Ghosh Abir , Swain Sunandini , Metya Atanu K.
Published: October 2024

This study reveals how electric fields influence the desorption of interfacial water near hydrophilic mica, with significant implications for surface modification and advancements in energy and biological applications.
Customizing PBE exchange–correlation functionals: a comprehensive approach for band gap prediction in diverse semiconductors
Authors: Bhattacharjee Satadeep , Koshi Namitha Anna , Lee Seung-Cheol
Published: October 2024

Comparison of Band Gap Predictions from DFT Functionals: Superior predictability of the proposed (Present) functional.
Accelerated molecular dynamics study of the interaction mechanism between small molecule inhibitors and phosphoglycerate mutase 1
Authors: Sun Yanqi , Jia Chaoyue , Zhang Shaolong , Zhang Qinggang , Chen Jianzhong , Liu Xinguo
Published: October 2024

Decoding the working mechanism and hot spots of PGAM1 bound to small molecule inhibitors.
Laser-induced high-entropy alloys as long-duration bifunctional electrocatalysts for seawater splitting
Authors: Xie Yunchao , Xu Shichen , Meng Andrew C. , Zheng Bujingda , Chen Zhenru , Tour James M. , Lin Jian
Published: October 2024

This work presents a rapid in situ synthesis of FeNiCoCrRu high entropy alloy with porous structures via CO2 laser induction under ambient conditions. FeNiCoCrRu exhibits excellent seawater electrolysis and a superior long duration of >3000 hours.
Combined temperature and salinity effects on the passive sampling of PAHs with an assessment of impacts to petroleum toxicity
Authors: Ola Ibukun , Drebenstedt Carsten , Burgess Robert M. , Tidwell Lane , Anderson Kim , Hoth Nils , Külls Christoph
Published: October 2024

In equilibrium-based passive sampling applications, the accuracy of estimating freely dissolved concentration (Cfree) of hydrophobic organic compounds (HOCs) relies on the passive sampler-water partition coefficient (KPS–W) values applied.
Interplanar synergy of a copper-based electrocatalyst favors the reduction of CO2 into C2+ products
Authors: Li Jiangnan , Duan Xinyi , Wu Chao , Cao Yucheng , Duan Zhiyao , Fan Wenjun , Zhang Peng , Zhang Fuxiang
Published: October 2024

A Cu-based catalyst with interplanar synergy between the Cu(100) and Cu(111) facets significantly enhances C2+ selectivity in CO2 electroreduction, achieving a 78% faradaic efficiency and 663 mA cm−2 partial current density.
Acute supplementation with a curcuminoid-based formulation fails to enhance resting or exercise-induced NRF2 activity in males and females
Authors: Thorley Josh , Alhebshi Abrar , Rodriguez-Mateos Ana , Zhang Zicheng , Bailey Stephen J. , Martin Neil R. W. , Bishop Nicolette C. , Clifford Tom
Published: October 2024

Supplementation with a curcuminoid-based formulation for four days did not augment nuclear factor erythroid 2-related factor 2 (NRF2) activity in peripheral blood mononuclear cells at rest and after strenuous plyometric exercise.
Effects of Clostridium butyricum and inulin supplementation on intestinal microbial composition in high-fat diet fed mice
Authors: Liu Jing , Zhang Suhua , Weng Huachun
Published: October 2024

Clostridium butyricum and inulin could improve dislipidemia, abnormal glucose tolerance and change intestinal microbial composition in high-fat diet (HFD) mice, increasing Parabacteroides, Bacteroides and Ruminococcaceae and regulating FGF21.
Accurate determination of ultra-trace REEs in seawater using a membrane desolvation Q-ICP-MS coupled with an online automatic separation system
Authors: Zhu Ji-Hao , Chu Feng-You , Liang Feng , Luo Xian-Ying , Liu Qiang , Xu Quan-Hui , Yu Wei , Li Yong-Chun , Lu Jiang-Gu , Li Yun-Xiu , Dong Yan-Hui , Li Huai-Ming , Zhao Jun , Zhang Cai
Published: October 2024

A highly precise method, based on a traditional Q-ICP-MS coupled with an online automatic separation system and membrane desolvation sample introduction device, was developed for accurate determination of ultra-trace REEs in seawater samples.
Rapid low-cost assembly of modular microvessel-on-a-chip with benchtop xurography
Authors: Agarwal Shashwat S. , Cortes-Medina Marcos , Holter Jacob C. , Avendano Alex , Tinapple Joseph W. , Barlage Joseph M. , Menyhert Miles M. , Onua Lotanna M. , Song Jonathan W.
Published: October 2024

Our study is a novel implementation of xurography for multi-layer microfluidic device fabrication. We demonstrate the versatility of this approach by presenting several modular 3D vessel-matrix arrangements.
Synthesis of gum tragacanth-starch hydrogels for water purification
Authors: Ahmad Sana , Imran Saleha
Published: October 2024

Biodegradable starch/gum tragacanth hydrogels were prepared using polyvinyl alcohol (PVA) as a cross-linker. The blended hydrogels were used as an eco-friendly effective adsorbent for the removal of dyes from aqueous solutions.
Graphene-based electrochemical sensors for antibiotics: sensing theories, synthetic methods, and on-site monitoring applications
Authors: Zhu Yangguang , Ye Chen , Xiao Xiao , Sun Zhuang , Li Xiufen , Fu Li , Karimi-Maleh Hassan , Chen Jun , Lin Cheng-Te
Published: October 2024

The successful construction of objective sensors needs to focus on the theoretical elaboration of sensing mechanisms and practical applications for on-site monitoring antibiotics.
Effective enrichment of glycated proteome using ultrasmall gold nanoclusters functionalized with boronic acid
Authors: Heo Hongmae , Cho Seonghyeon , Kim Yuhyeon , Ahn Soomin , Mok Jeong-hun , Lee Hookeun , Lee Dongil
Published: October 2024

A novel approach was developed for the first time by combining ultrasmall Au22 nanoclusters with boronic acid (BA) affinity chemistry, achieving highly efficient enrichment of early-stage glycated peptides.
Green synthesis of zinc oxide nanoparticles using plant extract for catalysis applications
Authors: Peta Sreenivasulu , Singh Sadhana
Published: October 2024

The peel extract of Citrus sinensis was used as a reducing and capping agent for green ZnO NPs synthesis, characterized using XRD, SEM, FT-IR, TGA/DTA, UV-Vis, and TEM techniques. These materials efficiently catalyzed the alkylation of acetophenone.
Ruthenium-catalyzed electrochemical C–H activation of benzamidine hydrochlorides with internal alkynes for the synthesis of 1-aminoisoquinolines
Authors: Patil Nilam , Subramanian Kripa , Bhanage Bhalchandra M.
Published: October 2024

A novel electrochemical procedure for synthesizing 1-aminoisoquinoline derivatives using Ru(iii)-catalyzed annulation of benzamidine hydrochlorides and alkynes. It eliminates the requirement for stoichiometric quantities of chemical oxidants.
Synthesis, antioxidant and structural properties of modified ebselen derivatives and conjugates
Authors: Doig Adrian I. , Sands Kai N. , Boongaling Bienca , Zhou Wen , Back Thomas G.
Published: October 2024

Hybrid and conjugate derivatives of ebselen provided varying antioxidant activities. An unusual salt containing a tricoordinate Se pincer anion afforded activity >130 times that of the parent ebselen.
Coordination tuning of Ni/Fe complex-based electrocatalysts for enhanced oxygen evolution
Authors: Zhou Hongbo , Hao Xuan , Guan Jiexin , Deng Yilin , Wei Zi , Liu Yashu , Zhu Guoxing
Published: October 2024

The 2,2′-bpy coordination shells surrounding the Ni/Fe active sites of NiFe(2,2′-bpy)n@CNT materials effectively boost OER catalysis.
Aminated reduced graphene oxide-CuFe2O4 nanohybride adsorbent for efficient removal of imidacloprid pesticide
Authors: Abd-Rabboh Hisham S. M. , Kamel Ayman H.
Published: October 2024

To remove organic and inorganic agrochemicals from contaminated soil and water, adsorption has been regarded as a viable remediation approach.
Effect of carbon black supports on the hydrogen evolution reaction activity of Pd nanoparticle electrocatalysts synthesized via solution plasma sputtering
Authors: Chantaramethakul Jidapa , Hussakan Chadapat , Yenmankhong Yanisa , Chandeang Praewpanit , Techapiesancharoenkij Ratchatee , Hirunpinyopas Wisit , Kasmui  , Kurniawan Cepi , Panomsuwan Gasidit
Published: October 2024

The effect of carbon black supports on Pd-nanoparticle electrocatalysts synthesized via solution plasma sputtering for HER has been investigated.
Mixed-ligand copper(ii)-diimine complexes of 3-formylchromone-N4-phenyl thiosemicarbazone: 5,6-dmp co-ligand confers enhanced cytotoxicity
Authors: Mamindla Anjaneyulu , Murugan Dhanashree , Varadhan Manikandan , Ajaykamal Tamilarasan , Rangasamy Loganathan , Palaniandavar Mallayan , Rajendiran Venugopal
Published: October 2024

The higher DNA binding ability, lipophilicity, reversible CuII/CuI redox behavior, and ability to oxidatively cleave DNA and to produce ROS confers on the 5,6-dmp complex remarkable cytotoxicity (IC50, 1.26 μM) against HeLa cervical cancer cells.
Preparation and demulsification performance of magnetic demulsifier Fe3N@F
Authors: Liu Chao , Jia Xinlei , Wang Yonghui , Liu Yanjuan , Qin Weining , Wei Lixin
Published: October 2024

By observing the microdroplet microstructure before and after demulsification, it is found that the Fe3N@F magnetic demulsifier exhibits favorable coalescence, flocculation, and bridging capabilities.
Sustained antibacterial release of zwitterionic globular hyperbranched polymer dots intercalated into layered double hydroxides
Authors: Liu Chun-Kuei , Su Fang-Yi , Juang Tzong-Yuan , Liu Yung-Chuan
Published: October 2024

Zwitterionic HBP dots intercalated into LDHs for sustained antibacterial release over 5 days, implying the potential combination of HBP/LDH with drugs for application to antimicrobial wound dressings or biocompatible drug delivery carriers.
Multimodal antibacterial potency of newly designed and synthesized Schiff's/Mannich based coumarin derivatives: potential inhibitors of bacterial DNA gyrase and biofilm production
Authors: Pakeeraiah Kakarla , Swain Pragyan Paramita , Sahoo Alaka , Panda Preetesh Kumar , Mahapatra Monalisa , Mal Suvadeep , Sahoo Rajesh Kumar , Sahu Pratap Kumar , Paidesetty Sudhir Kumar
Published: October 2024

The briskened urge to develop potential antibacterial candidates against multidrug-resistant pathogens has motivated the present research study.
Solid acids as cocatalysts in the chelation-assisted hydroacylation of alkenes and alkynes
Authors: Vergara-Arenas Blanca I. , García-Ríos Eréndira , Gaviño Rubén , Cárdenas Jorge , Martinez-Garcia Alfredo , Juarez-Arellano Erick A. , López-Torres Adolfo , Morales-Serna José A.
Published: October 2024

Hydroacylation of alkenes and alkynes in the presence of solid acids.
Sequential effects of two cations on the fluorescence emission of a coordination polymer with Zn4O core in node
Authors: Sendh Jagajiban , Baruah Jubaraj B.
Published: October 2024

Distinct changes in the fluorescence emissions of a free ligand than a 2D-zinc-coordination polymer by sequential interactions with different cations were observed.
C12 aromatic triol-furoin and diol-furil from bio-based 5-(hydroxymethyl)furfural: enhanced selective synthesis, scale-up and mechanistic insight into cyclic catalysis
Authors: Vu Thi Tuyet Thuy , Liu Shentan , Jonušis Mantas , Jonušienė Simona , Choi Jinsik , Ismail Mohamed , Rehnberg Nicola , Hatti-Kaul Rajni , Pyo Sang-Hyun
Published: October 2024

Valorization of 5-(hydroxymethyl)furfural (5-HMF), a versatile renewable C6 chemical, into C12 heteroaromatic polyols, 5,5′-bis(hydroxymethyl)furoin (DHMF) and 5,5′-bis(hydroxymethyl)furil (BHMF) through carboligation and oxidation.
A tetraphenylborate-based anionic metal–organic framework as a versatile solid electrolyte for fast Li+, Na+, K+, Mg2+, Ca2+, and Zn2+ transportation
Authors: Xia Qingchun , Han Kaixin , Ma Xuxiao , Qiu Pengtao , Li Zhiyong , Chen Xuenian
Published: October 2024

Tetraphenylborate (BPh4−) has been widely employed in the field of electrolytes and displayed better ionic conductivities in polymer solid-state Li+ conductors.
Spotting d-band centers of single-atom catalysts by oxygen intermediate-boosted electrochemiluminescence
Authors: Xie Ruyu , Li Kaitao , Tian Rui , Lu Chao
Published: October 2024

We have proposed an oxygen intermediate-boosted electrochemiluminescence probe for rapid spotting of the d-band centers of single-atom catalysts: the d-band centers closer to the Fermi level contributed to higher luminol ECL intensities.
A changeable critical state for a switchable photocurrent direction via the photo-electrochemical photocurrent polarity switching effect in BiFeO3 nanoparticulate films
Authors: Ajay  , Saroha Jyoti , Ingole Pravin Popinand
Published: October 2024

A PEC system utilizing BiFeO3 nanoparticulate films, exhibiting tunable photocurrent reversal controlled by electrolyte composition is reported. The system's behavior, predicted by the Nernst equation, provides valuable insights for PEC-catalysis.
Systematic design and functionalisation of amorphous zirconium metal–organic frameworks
Authors: Ma Nattapol , Kosasang Soracha , Theissen Jennifer , Gys Nick , Hauffman Tom , Otake Ken-ichi , Horike Satoshi , Ameloot Rob
Published: October 2024

A bottom-up approach for synthesising a series of Zr-based amorphous MOFs enables tunable proton conductivity, porosity, and mechanical properties.
Visible-light-responsive hybrid photocatalysts for quantitative conversion of CO2 to highly concentrated formate solutions
Authors: McQueen Ewan , Sakakibara Noritaka , Kamogawa Kei , Zwijnenburg Martijn A. , Tamaki Yusuke , Ishitani Osamu , Sprick Reiner Sebastian
Published: October 2024

This highly efficient hybrid photocatalytic system can quantitatively convert CO2 to formate and produce 0.4 M of formate solution without additional concentration enrichment.
Improving heterologous expression of laccase by Pichia pastoris via vanillin-induced stress response and its application for removing inhibitors of lignocellulose hydrolysate
Authors: Liu Nan , Li Bo , Zhao Xuebing
Published: October 2024

Vanillin-sensitive promoters were screened and employed to improve the heterologous expression of laccase in Pichia pastoris. The recombinant yeast could well remove phenolic compounds to improve the fermentability of wheat straw hydrolysate.
Chain stretching in brushes favors sequence recognition for nucleobase-functionalized flexible precise oligomers
Authors: Grafskaia Kseniia , Qin Qian , Li Jie , Magnin Delphine , Dellemme David , Surin Mathieu , Glinel Karine , Jonas Alain M.
Published: October 2024

Flexible oligomers having precise sequences of nucleobases do not specifically recognize surface-grafted target chains at low grafting density. Moderately higher grafting densities promote sequence-specific recognition thanks to chain stretching.
Hydrogen sulfite ion functionalized cationic covalent organic framework nanosheets as a separator boosted the energy storage performance of Li–S batteries
Authors: Jia Bingxin , Sun Bo , Yu Hongmin , Yao Chan , Xie Wei , Xu Yanhong
Published: October 2024

EB-COF:HSO3 was prepared by solvothermal and ion-exchange methods to enhance Li–S battery separators, suppressing the “shuttle effect” of soluble polysulfides and improving charge/discharge efficiencies with excellent electrochemical performance.
Understanding the swelling behavior of Ti3C2Tx MXene membranes in aqueous media
Authors: Helal Mohamed I. , Sinopoli Alessandro , Gladich Ivan , Tong Yongfeng , Alfahel Radwan , Gomez Tricia , Mahmoud Khaled A.
Published: October 2024

Two-dimensional (2D) lamellar MXene membranes have demonstrated ultrafast water permeance and outstanding ion rejection performance, thus showing great potential for water purification.
Regulation of electrocatalytic properties of high entropy alloy electrocatalysts for the oxygen evolution reaction
Authors: Wang Kaixin , Wang Guoqiang , Liu Ye , Cai Qianqian , Chen Xing , Zhang Lei , Lv Xiaojun
Published: October 2024

We briefly introduce the four core effects of HEAs and various regulatory strategies for HEA catalysts. This will help scholars further understand the advantages and flexibility of HEAs as catalysts.
Machine learning for deconstructing contributions of atomic characterizations to achieve hybridization-determined electron transfer in a perovskite catalyst
Authors: Zhu Jun , Song Mengdan , Qian Qiling , Yue Yang , Qian Guangren , Zhang Jia
Published: October 2024

Machine learning deconstructed the atomic contribution of a perovskite to catalytic toluene decomposition and found that wider hybridization resulted in smaller impedance, faster electron transfer speed, and enhanced catalytic activity.
K–Co–Mo–Sx chalcogel: high-capacity removal of Pb2+ and Ag+ and the underlying mechanisms
Authors: Nie Jing , Chandra Roy Subrata , Dhami Sital , Islam Taohedul , Amin Ruhul , Zhu Xianchun , Taylor-Pashow Kathryn , Han Fengxiang X. , Islam Saiful M.
Published: October 2024

Disordered aggregated porous nanoparticles of KCMS are highly efficient and have exceptionally high sorption capacity in removing Ag+ and Pb2+ following the exchange of K+ and Co2+ ions bonded electrostatically and covalently in KCMS, respectively.
Interface and interlayer electron/exciton–phonon coupling of TMDs/InSe for efficient charge transfer and ultrafast dynamics: implications for field-effect devices
Authors: Kan Shan-Shan , Deng Shi-Xuan , Jiang Xiao-Meng , Liu Yu-Xin , Jiang Ming-Kun , Ren Zhe-Kun , Yao Cheng-Bao
Published: October 2024

Constructing multifunctional application-based TMDs/InSe homo/hetero-heterojunctions for improving absorption and transport properties: implications for field-effect devices.
A soft molecular single-source precursor approach to synthesize a nanostructured Co9S8 (pre)catalyst for efficient water oxidation and biomass valorization
Authors: Dasgupta Basundhara , Ghosh Suptish , Walter Carsten , Budde Markus S. , Marquardt Georg J. , Chen Han-Hsu , Breithaupt Markus G. M. , Yilmaz Tolga , Garmatter Christoph , Ahamad Tamanna , Zebger Ingo , Driess Matthias , Menezes Prashanth W.
Published: October 2024

A nanocrystalline Co9S8 (pre)catalyst derived from a novel {CoIIS4} complex is reported for the oxygen evolution reaction (OER) and selective biomass valorization. During OER, Co9S8 reconstructs completely into a CoOOH active phase via S-leaching.
Asymmetrical Sc coordination-induced bridging structure and surface relaxation for boosting H2O2 photoactivation in Fenton-like catalysis
Authors: Liu Cong , Yu Mingchuan , Ma Yuhao , Zhang Yuanzheng , Zhou Yufei , Niu Junfeng
Published: October 2024

A single-atom of the transition metal scandium is introduced into the g-C3N4/MoSe2 heterojunction interfaces to form a single-atom bridging structure (Se–Sc–N) for H2O2 activation in a photo-Fenton-like system.
Efficient utilization of the active sites of MXene: MXene/PSSNa films with a 3D-stabilized porous structure as high-capacitance and high-rate electrodes for flexible supercapacitors
Authors: Song Ying , Liu Yaqing , Ao Qi , Jiang Lin , Lv Xiaoxiao , Tong Xinglai , Jiang Tuohao , Yao Yuanqing , Tang Jun
Published: October 2024

Based on the interaction of covalent bonds and hydrogen bonds, a 3D stable porous MXene-based electrode was constructed. Ti3C2Tx@MPS film electrodes were investigated to realize flexible supercapacitors.
A single-injection vaccine providing protection against two HPV types
Authors: Zhang Jianchen , Liu Yu , Guan Ying , Zhang Yongjun
Published: October 2024

A bivalent single-injection HPV vaccine was designed using a new pulsatile release drug carrier.
Enzymatically-induced dynamic assemblies from surface functional stomatocyte nanoreactors
Authors: Fusi Alexander D. , Li Yudong , Tholen Marrit M. E. , Cieraad Marlo , Albertazzi Lorenzo , Padial Tania Patiño , van Hest Jan C. M. , Abdelmohsen Loai K. E. A.
Published: October 2024

Pursuing collective behaviors, we present enzyme-loaded polymersome stomatocytes with stigmergy-based communication capable of signal production, reception, and response by transiently clustering with surface complementary artificial species.
A unimolecular artificial cation channel based on cascaded hydrated acid groups
Authors: Xin Pengyang , Yuan Hailong , Zhang Long , Zhu Qiuhui , Ning Xunpeng , Song Yufei , Shu Yuqing , Sun Yonghui
Published: October 2024

Based on the cascade dehydration concept, an amphiphilic unimolecular cation channel was synthesized by attaching multiple carboxyl groups to both sides of hybrid molecule, resulting in excellent cation transport activity and pH-modulated properties.
The cyano positional isomerism strategy for constructing mitochondria-targeted AIEgens with type I reactive oxygen species generation capability
Authors: Zhuang Jiabao , Pan Quan , Zhou Chunli , Cai Ziying , Li Nan , Zhao Na
Published: October 2024

Based on the cyano positional isomerism strategy, a cationic AIEgen was developed, which can specifically stain mitochondria, and ablate cancer cells through potent type I photodynamic therapy both in vitro and in multicellular tumor spheroid models.
Breakthrough in cancer therapy: lutetium texaphyrin–celecoxib conjugate for immune and photodynamic treatment
Authors: Ding Qihang , Wang Yue , Zhang Pengfei , Mei Ling
Published: October 2024

Kim et al. present a small-molecule photosensitizer, LuCXB, which combines a COX-2 inhibitor (celecoxib) with a near-infrared lutetium texaphyrin photocatalyst and was loaded CD133-aptamer functionalized exosome for cancer stem cells targeting.
Electron-withdrawing quinone polymers with enhanced conjugated planarity for n-type organic thermoelectrics
Authors: Luo Xi , Xiong Wei , Tang Haoran , Cai Houji , Wang Jiashuai , Yu Jiangkai , Shao Lin , Huang Fei , Cao Yong
Published: October 2024

A new electron-withdrawing quinone unit was developed for n-type thermoelectrics. Two n-type polymers were constructed, and the polymer with selenophene exhibited enhanced planarity and better thermoelectric performance.
A TaOx-based self-rectifying memristor for a highly compact thermal in-sensor computing system
Authors: Cao Lijuan , Luo Yunhao , Yao Jiaping , Ge Xiang , Luo Maoyuan , Li Jiaqi , Cheng Xiaomin , Yang Rui , Miao Xiangshui
Published: October 2024

We propose a highly compact thermal in-sensor computing system based on a sensory crossbar array and leaky integrate-and-fire (LIF) neurons, both constructed with TaOx-based memristors.
Enhancement of 4T2 → 4A2 with temperature via energy transfer of the optical thermometer Mg5Al7O16:Cr3+
Authors: Wei Yang , Jin Ye , Chen Yifei , Hu Weixin , Wang Chongzhou , Zhang Zhihui , Meng Fancheng , Huang Fuxiang , Ma Li , Wang Xiao-jun , Ren Haishen
Published: October 2024

In Mg5Al7O16, Cr3+ occupies octahedral Mg2+ and Al3+ sites. As temperature rises, 4T2 → 4A2 emission rises while 2E → 4A2 emission falls due to energy transfer from 2E to 4T2via phonon assisting. The highest relative sensitivity gets 1.80% K−1 at 303 K.