bluuebunny/crossref_metadata_2025 huggingface dataset:
As carreiras do magistério federal e a greve dos docentes de 2012: relações com um projeto educacional
Authors: D’Agostini Adriana , Titton Mauro
Published: August 2022

Abordaremos neste artigo a análise e os resultados de uma pesquisa documental, que versa acerca das repercussões sobre a carreira e o trabalho docente arquitetado através da ação dos governos de conciliação de classes, que atuaram no sentido de reconverter as Universidades Públicas aos interesses de expansão do capital acerca da educação, principalmente a superior. O foco é a carreira docente como parte de um projeto de Universidade Pública, que a partir da imposição da Lei 12.772/2012 (BRASIL, 2012b), aprovada contra o movimento docente no contexto de grande mobilização da greve docente de 2012, culminou na desestruturação completa da carreira docente e numa reforma universitária fatiada com perspectiva privatista e mercadológica.
Carreira docente: importante pilar para “desconjuntar” o projeto de universidade pública
Authors: Ribeiro Claudio Rezende , Flores Renata Lucia Baptista , Granemann Sara
Published: August 2022

A greve nacional dos docentes das Instituições Federais de Ensino, organizada pelo Andes-SN em 2012, teve como reivindicações centrais a organização da carreira docente, o reajuste salarial e a melhoria das condições de trabalho. Este artigo pretende dar centralidade à luta pela defesa da carreira – por meio de breve reconstrução histórica da luta travada naquela greve – como uma garantia do funcionamento público das universidades estatais. Primeiramente, retomamos alguns de seus antecedentes principais; em seguida, apresentamos as consequências das conquistas e das derrotas da greve, indicando as contradições inerentes da continuidade do processo de privatização a partir de novas alterações na carreira no mesmo sentido daquele imposto pelo governo federal do Partido dos Trabalhadores em 2012, com o apoio do seu braço “sindical”, o PROIFES-Federação.
Movimento sindical docente na Universidade Federal do Amapá: condições locais e articulações nacionais na construção da greve de 2012
Authors: Guimarães André Rodrigues , Cavlak Iuri , Caldas Yurgel Pantoja
Published: August 2022

Neste artigo analisa-se o movimento sindical docente na Universidade Federal do Amapá (Unifap), destacando o envolvimento com a construção da greve nacional da categoria, em 2012. Consideram-se o contexto nacional da deflagração da greve protagonizada pelo Sindicato Nacional dos Docentes das Instituições de Ensino Superior (ANDES-SN), o processo de mobilização, a pauta de reivindicações e o desfecho do movimento. Destacam-se aspectos históricos da Unifap, com ênfase na criação do Sindicato dos Docentes da Unifap, em 1994, e sua vinculação ao ANDES-SN, como Seção Sindical, em 2002. Informações empíricas foram obtidas via questionário aberto, respondido por docentes que participaram da greve e atuaram como dirigentes do Sindufap no período 2012-2020, para identificar o envolvimento com o movimento grevista, a mobilização local, a articulação com a luta nacional, o desfecho e o balanço da paralisação. Identifica-se que as precárias condições de trabalho e a defesa pela reestruturação da carreira foram elementos centrais na adesão ao movimento paredista, evidenciando articulação entre as demandas locais e a reivindicação nacional. O envolvimento do Sindufap com a greve foi ativo e mobilizador, fazendo do movimento um importante espaço de formação política. Em relação ao desfecho, percebe-se avaliação negativa em relação ao atendimento da pauta grevista, mas positiva em seu balanço político. Em suma, a experiência local da greve de 2012 foi extraordinária: as assembleias e os atos com grande participação da categoria, somados à união na luta com estudantes e técnico-administrativos, eletrizaram a categoria, na esperança de que uma mudança efetiva estivesse no horizonte possível da força coletiva.
Ultra-Processed Food Consumption and its Association with Nutritional Status and Diet-Related Non-Communicable Diseases among School-Aged Children in Lilongwe City, Malawi
Authors: Kamanga Patricia , Zhang Bo , Kaphera Samson
Published: August 2022

In underdeveloped nations like Malawi, Non-Communicable Diseases (NCDs) have received less attention despite increasing NCDs morbidity and incidence rates. NCDs are responsible for 68% of all deaths worldwide each year. Dietary problems are the most common causes of these deaths. In underdeveloped countries, NCDs are responsible for two-thirds of all fatalities. In addition, developing countries account for two out of every three overweight and obese individuals worldwide. Lifestyle factors such as Ultra-Processed Foods (UPFs) consumption is among the causes.

Purpose of the Study: To investigate ultra-processed food consumption and its association with nutritional status and diet-related NCDs among school-aged children.

Methods: The research was conducted from March-April, 2021, using cross-sectional quantitative methods. A systematic random sample of 382 school-aged children was drawn to collect data. Data were analyzed using the R software package by frequency tables, means, and Chi-Square.

Study Findings: Findings suggest high consumption (95.6%) of UPFs, which included flitters, carbonated drinks, processed juice, French fries, and sweets. The study further attributed the high consumption of UPFs to age, residence, price, and availability. In addition, in children who consume high amounts of UPFs, dental problems and high mid-upper arm circumference were common.

Conclusion: Prevalence of UPFs is high among school-aged children in Lilongwe city. Although there are reported differences between these two locations, the locations are generally similar. However, age, residence, price, and availability seem to influence UPFs consumption behaviors. In later years, this may predispose children to be cardiovascular and metabolic conditions.
Evaluation of serum proteome from Indian psoriasis patients
Authors:   Yenepoya Medical College, Yenepoya (Deemed to be university), Deralakatte, Mangalore, India, R. Shah Saiqa
Published: August 2022

Psoriasis is a polygenic chronic skin condition, associated with many systemic disorders. Though it is most studied dermatological condition, molecular mechanism leading to its pathogenesis is still unclear. An insight into its proteome may help unrevealing some biomarkers and therapeutic targets. In this study, we carried out mass spectrometry based quantitative proteomic analysis of serum from psoriasis patients by employing Tandem Mass Tags (TMT) approach. We identified 861,887 MS/MS spectra corresponding to 493 proteins. These dysregulated proteins were further classified by Gene Ontology and protein-protein interaction of dys-regulated proteins revealed networks in psoriasis patients.
Green synthesis and characterization of bisphosphonate conjugated gold nanoparticle with Asparagus racemosus root extract
Authors:   Department of Orthodontics and Dentofacial Orthopaedics, Saveetha dental college and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University Chennai-77, India, Harikrishnan Sruthi
Published: August 2022

Bisphosphonates improve orthodontic anchorage. More targeted action of this drug can be achieved through its conjugation with gold nanoparticles. Asparagus racemosus is a green edible medicinal plant used in Ayurvedic preparations to treat aging, vigor, immunity, longevity, and skeletal issues. Therefore, it is of interest to report the green synthesized Bisphosphonate conjugated gold nanoparticles with Asparagus racemosus extract and to characterize them.
Analysis of Bitter honey using gas chromatography and Tandem Mass Spectrometry
Authors:   Department of Pharmacognosy, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Gorimedu, Puducherry -605006, India, Joshna Koodathil
Published: August 2022

Honey has been consumed by humans since ancient times. Honey contains volatile compounds like aldehyde, alcohol, ketone, hydrocarbon, terpenes, acids, benzene compounds. These compounds represent the fingerprint of monofloral honey there by providing information about the floral and geographical origin of honey. The volatile compounds present in honey not only contribute the aroma but also associated with the therapeutic activities of honey. In the present study, the GCMS/MS analysis of bitter honey was carried out to identify the presence of volatile compounds. This is the first study to determine the volatile compounds from ethyl acetate extract of bitter honey produced in the Nilgiri biosphere. Among the eighteen compounds detected, the majority of the compounds were reported to be therapeutically active. Hence further studies regarding the isolation of these compounds could be beneficial in the treatment of various diseases.
Molecular docking analysis of tetracyclic triterpenoids from Cassia fistula L. with targets for diabetes mellitus
Authors:   DBT-BIF Centre, Holy Cross College (Autonomous), Tiruchirappalli, Tamilnadu, India, Sabapathy Indu
Published: August 2022

It is of interest to develop effective drugs for diabetes mellitus. We document the molecular docking analysis data of tetra-cyclic-tri-terpenoids from Cassia fistula L. with targets for diabetes mellitus.
A computational workflow for predicting cancer neo-antigens
Authors:   Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, 575018, India, Kasaragod Sandeep
Published: August 2022

Neo-antigens presented on cell surface play a pivotal role in the success of immunotherapies. Peptides derived from mutant proteins are thought to be the primary source of neo-antigens presented on the surface of cancer cells. Mutation data from cancer genome sequencing is often used to predict cancer neo-antigens. However, this strategy is associated with significant false positives as many coding mutations may not be expressed at the protein level. Hence, we describe a computational workflow to integrate genomic and proteomic data to predictpotential neo-antigens.
Gene polymorphism among hypertensive patients with coronary artery disease
Authors:   Department of Biochemistry, Vinayaka Mission’s Kirupananda Variyar Medical college and Hospitals , Salem, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem -636 308, Tamilnadu, India, Selvakumar D
Published: August 2022

The obstruction of the coronary arteries causes Coronary Artery Disease (CAD). It has been reported that interleukin-6 gene is related to the development of cardiovascular diseases such as atherosclerosis and coronary artery disease. This was due to the large variability and short half-life of interleukin 6 (IL-6). There are few studies on the link between interleukin 6 and CAD on the patients with hypertension. Therefore, goal of this study was to see if there is a link between IL-6 gene polymorphisms and coronary artery disease with hypertension patients. The polymorphisms were carried out by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). The data was determined for statistical significance using chi-square analysis. A significant difference was found in the GG genotype of IL-6 -174, which was more frequent in cases of CAD (48.67 %) than in controls (8%) and 95% CI was 0.473455 - 0.500326; P<0.010620511. The GG genotype of IL-6-572C/G polymorphism was more frequent in cases of CAD (42.6%) compared with controls (8%) and 95% CI 0.386724 - 0.480945; P<0.017939631). likewise, significant association of variant allele G with CAD patients was reported. Hypertension was significantly higher among patients as compared to controls (P<0.022847535). Our findings indicated that both gene polymorphisms may be associated with development of CAD.
Cone-beam computed tomography (CBCT) analysis of maxillary sinus septa in Indians
Authors:   Department of Oral and Maxillofacial surgery, AECS Maaruti College of Dental Sciences and Research Renter, Bannerghata road, Bangalore 560076, Archana T. Sukumar
Published: August 2022

It is of interest to assess the presence of maxillary sinus septae in patients undergoing implant treatment using Cone Beam Computed Tomography (CBCT).This retrospective study evaluated CBCT scans of 99 patients who opted for implant placement. A total of 198 sinuses were analyzed. The cases were divided into two group’s namely edentulous group and non-edentulous groups. The location of septa was divided for analysis into 3 regions namely, the anterior (1st and 2nd premolar), middle (1st and 2nd molar) and posterior (behind 2nd molar) regions. Out of 198 sinuses assessed 15 sinuses had septa. It was more common in males. Mean height of septa was 7.7mm. It was more commonly seen in the middle region (1st and 2nd molar). All of the septa were partial in nature. Septa were common on the right side. It was absent in the edentulous group. To conclude this study showed low prevalence of septa in patients who were assessed as a part of pre-operative planning for implant placement. Modified sinus lift procedures were completed for placement of bone grafts in patients with septa,. This reduced the chances of membrane perforation and increases the chances of better outcomes. CBCT with its low cost and high resolution is useful for assessing the sinus.
Molecular docking analysis of metformin analogues with GSK-3β
Authors:   Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, India, Rajagopal Ponnu lakshmi
Published: August 2022

We report the molecular docking analysis of four analogues of metformin [1-Carbamimidoyl-1,2-dimethylguanidine hydrochloride, Metformin hydrochloride, N1,N1-Dimethyl-N5-methylbiguanide hydrochloride, and N1,N1,N5,N5-Tetrakis(methyl-biguanide hydrochloride] with GSK3.
Antimicrobial effects of copper nanoparticles with green tea and neem formulation
Authors:   Department of Orthodontics and Dentofacial Orthopaedics, Saveetha Dental College and Hospital, Saveetha Institute Of Medical and Technical Sciences, Saveetha University, 162, Poonamallee high road, Chennai – 600077, Tamilnadu, India, Thomas Anjali Anna
Published: August 2022

Nanotechnology is the science which is about manipulating matter, atom by atom and is associated with particles smaller than 100 nm in size. Copper nanoparticles are used mainly due to its surplus amount, low cost, easy availability and biocompatible property. Green synthesis of copper nanoparticles is very simple, economical and eco-friendly method that does not involve any toxic chemicals. The aim of our study is green synthesis of copper nanoparticles using green tea and neem formulation and assessment of its antimicrobial effects.20mM of copper sulphate solution is mixed with 40mL of plant extract and 60 mL of distilled water was added and made it into 100 ml solution. Once the copper nanoparticles are synthesized the solution is characterized using UV- vis-spectroscopy and was scanned in double beam UV-vis- spectrophotometer from 300 nm to 700nm wavelength. The antimicrobial property of copper nanoparticle is evaluated by agar well diffusion method. The colour change from green to brown and peak observed in UV-vis- spectrophotometer was associated with the synthesis of copper nanoparticles. Copper nanoparticle from green tea and tea extract has good antimicrobial activity against S.mutans, C.albicans, E.faecalis, & S.aureus. Copper nanoparticles can be efficiently synthesised from green and neem formulation. These copper nanoparticles showed good antibacterial properties and are effective against oral pathogens.
Effect of Citrullus colocynth fruit extract on pro and anti apoptotic molecules in human melanoma cell line (A375)
Authors:   Department of physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077, Tamilnadu, India, Jayachandran Sariga
Published: August 2022

Melanoma remains a major cause of death worldwide. Chemotherapy might be used to treat advanced Melanoma which is associated with some side effects. Hence, providing proper treatment or proper employment of lower toxic substances is essential. Citrullus colocynthis, a medicinal plant, seems a potential anticancer herbal medicine against Melanoma via various efficient compounds. Therefore, it is of interest to analyze the effect of Citrullus colocynthis fruit extract on pro and anti apoptotic molecules in the human melanoma cell line (A375). Cell viability test was done using MTT assay. mRNA expression of Bax and Bcl2 was done by real-time PCR. The data was analyzed statistically by one way analysis of variance and Duncan multiple range test with graph prism version 5. p<0.05 was considered significant. Citrullus colocynthis extract caused a marked increase in cell death in a dose-dependent manner. At the end of 48 hours, maximum inhibition (50%) was at 400 and 500μg/ml. The study demonstrated that the effect of Citrullus colocynthis extract has elevated the Bax mRNA expression on human melanoma cell lines. Data shows that Citrullus colocynthis fruit extract has an anticancer effect on the human melanoma cell line (A375) by increasing the expression of Bax and Bcl2 and this could be because of the phytochemicals present in it.
Identification of coral endosymbionts of Veedhalai and Mandapam coasts of Palk Bay, India using small subunit rDNA
Authors:   Department of Marine and Coastal Studies, School of Energy, Environment and Natural Resources, Madurai Kamaraj University, Madurai–625021, Tamilnadu, India, Murugesan Rajesh Kannan
Published: August 2022

Coral endosymbionts act as a bio-indicator of coral ecosystem under extreme environmental conditions. The health of the coral ecosystem depends on the endosymbiont cell density of the coral hosts. Therefore, it is of interest to analyze ten coral fragments found to be under the genera Acropora, Favites, Favia, and Porites collected at various locations from Veedhalai to Mandapam, southeast coast of India during January 2019 to March 2019. The zooxanthellae cell count ranged between 4.08 (Porites sp.9) and 13.75×105 cells cm2 -1 (Favites sp.3). This indicates the health of the corals in the region. The genus (clade) level identification of endosymbionts was detected using the host excluding primers of small subunit DNA (nssrDNA). Bidirectional sequencing of 18S nrDNA gene (SSU) of all ten coral fragments show that the Veedhalai corals is associated with the genus Durusdinium (Clade D) but the corals of Mandapam is associated with the genera, Cladocopium (Clade C) and Durusdinium (Clade D). It is known that the thermal stress has negative impact on coral reef ecosystem of the world. The dominance of the genus Durusdinium in the scleractinian corals of Palk Bay may be due to frequent exposure to thermal stress. This thermotolerant endosymbionts is opportunistic. Thus, the corals of Veedhalai and Mandapam coasts, Palk Bay, India are necessarily packed with thermotolerant endosymbionts enabling conservation.
In vitro antioxidant and anti-diabetic analysis of Andrographis echioides and Andrographis paniculata ethanol extract
Authors:   Saveetha Dental College, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai, India, Sai Shreya Reddy Chevuru
Published: August 2022

It is of interest to analyse and compare the antioxidant and anti-diabetic activity of ethanolic extracts of Andrographis echioides and Andrographis paniculata. Andrographis echioides and Andrographis paniculata were collected from a local farm. In vitro antioxidant activity was assessed by the potential of Piperine, Lupeol, beta sitosterol; DPPH free radical scavenging assay was performed by Liyana Pathirana and Shahidi method. In vitro anti-diabetic activity was assessed by alpha amylase inhibitory activity and alpha glucosidase inhibitory activity. The data were analysed by one-way-ANOVA to check the statistical significance among the groups and considered at the levels of p<0.05. Both the ethanolic extracts of Andrographis echioides and Andrographis paniculata showed significant antioxidant and anti-diabetic potential in a dose-dependent manner (100-500μg) and can be used as potential antidiabetic agents. Similar to antioxidant potential, Andrographis paniculata exhibited an increased anti-diabetic potential compared to Andrographis echioides. Data shows that the ethanolic extracts of Andrographis echioides and Andrographis paniculata possessed antioxidant and anti-diabetic activity and hence our present findings conclude that both plants can be considered for the development of natural drugs for the management of diabetes.
Data on the effect of sub-epithelial connective tissue graft with hydroxyl-apatite for furcation treatment in Indians
Authors:   Rayatbahra Dental College and Hospital, Mohali India, Sharma Ena
Published: August 2022

Grade II furcation defect has a great potential for regeneration. Attempts have been made to regenerate lost periodontium in furcation defects through variety of approaches. A total of 22 patients with Grade II furcation defect were examined. The patients were sequentially grouped into three groups namely, (Group A) subepithelial connective tissue graft as a barrier membrane, (Group B) bovine bone graft material Bio-OssTM and (Group C) with the combination of the two. The treatment modalities show that there was a strong improvement in the resolution of the grade II furcation defects. The reduction in horizontal furcation defect measurement was 20.63% for group A. The change was found to be moderate (p=0.023*). The % change is 20.97% for group B and it is statistically significance (p = 0.001**). The % change was 20.78% in Group C with a good statistical significance (p=0.003**). Complete obliteration of the defect clinically and radio-graphically was observed for grade II furcation defect. Thus, the effect of sub-epithelial connective tissue graft with hydroxyl-apatite for furcation treatment in Indians is documented in this report.
Molecular docking analysis of mTOR protein kinase with chromatographically characterized compounds from Clerodendrum inerme L. leaves extract
Authors:   Department of Zoology, N. M. S. S. Vellaichamy Nadar College, Madurai 625019, Tamil Nadu, India, Arumugam Dhanalakshmi
Published: August 2022

The mTOR protein is known to be linked with cancer. Therefore, it is of interest to document the molecular docking analysis of mTOR protein kinase with chromatographically characterized compounds from Clerodendrum inerme L. leaves extract. The GC-MS analysis suggested that, totally 25 bioactive compounds were present in the extract of Clerodendrum inerme. Molecular docking analysis show that the bioactive compounds such as Triethoxysilanol, Piperazine dihydrochloridehydrate, 2,4(1H,3H)-Pyrimidinedione, 5-methyl and 4',7-Dihydroxyflavanone showed good glide score and glide energy within the acceptable and permissible limits of ADME properties for further consideration in drug discovery.
Sequence to predicted structure and function for DHX8
Authors:   Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), P.O. Box 6086, Riyadh 11442, Kingdom of Saudi Arabia, A Bakhrebah Muhammed
Published: August 2022

DEAH-box helicase 8 (DHX8) is a protein coded by the DHX8 gene in humans. Available information on the sequence to structure to function for this protein is limited in the literature. Therefore, it is of interest to document insights gleaned from the sequence to structure to functional analysis of the DHX8 protein using known software tools such as SMART, Prosite, Pfam, PANTHER, and InterProScan. We also present the predicted preliminary structure data for the protein to glean structure based functional insights.
Salivary retention of silver diamine fluoride
Authors:   Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India, Jabin Zohra
Published: August 2022

The topically applied fluorides are efficacious in both prevention against caries attack and inhibition of virulent bacteria. The purpose of this clinical trial was to assess the fluoride concentration in saliva before and after 38% SDF, 5% NaF and 1.23% ApF gel application on enamel and duration of its availability at different time intervals. The present randomized clinical trial was conducted among 60 healthy children aged between 6-12 years where at baseline the participants were instructed to spit for 2 min in sterile containers and the first saliva sample (S1) was taken. The participants were then randomly allocated into 3 different groups in which 38% Silver diamine fluoride, 5% Sodium fluoride and 1.23% ApF gel were applied respectively. The second saliva sample (S2) was collected after 5 min and patients were called after 1 hour for third saliva sample collection. The fluoride concentration was measured in the salivary samples. ANOVA test was used for evaluation and chi square t test was conducted for comparison of 3 groups. The fluoride concentration is comparatively slightly higher for the group receiving SDF than NaF and ApF at baseline, 5 min and 1 hour time interval but is not statistically significant. The mean scores of Fluoride concentration of the three groups were statistically significant at 5 min (F=63.556, p<0.0005) and 1 hour time interval (F=17.577, p<0.0005). Slightly increased salivary fluoride retention was observed post SDF application at 5min and 1 hour time interval when compared to Na F and ApF gel application. The present trial also concluded that topical fluoride application increases fluoride bioavailability in saliva thereby increasing tooth remineralization.
Antioxidant and anti-inflammatory activity of a nanoparticle based intracanal drugs
Authors:   Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India, Nasim Iffat
Published: August 2022

The most common intracanal medication is calcium hydroxide. Its efficacy can be affected by a number of factors, including pH, serum proteins, collagen, and dentin. It's also ineffective against E. faecalis and fungus, lacks an anti-inflammatory component, and has mixed reviews when it comes to pain relief. Natural alternatives to synthetic intracanal medication are being researched at the moment. We evaluated the antioxidant and anti-inflammatory activity of green synthesized silver nanoparticle based intracanal medicaments. Silver nanoparticles integrated into calcium hydroxide and graphene oxide nanoparticles were the experimental groups and Calcium hydroxide served as the control. Antioxidant activity was determined using the DPPH and Nitric oxide assays, while anti-inflammatory activity was determined using the protein denaturation and Xanthine Oxidase Inhibition assays. Both experimental groups had higher antioxidant activity than the control group based on DPPH and Nitric oxide assays. Calcium hydroxide combined with silver nanoparticles demonstrated improved anti-inflammatory efficacy in a protein denaturation and Xanthine oxidase inhibition assay. Within the constraints of an in vitro study, it can be concluded that intracanal medicaments containing silver nanoparticles can be employed efficiently during root canal preparation. In comparison to standard calcium hydroxide-based intracanal medicaments, it has effective antioxidant and anti-inflammatory effects.
Molecular docking analysis of long-chain alkanes with the β-lactamase BEL-1 from P. aeruginosa
Authors:   Department of Biotechnology, Vivekanandha College of Arts & Science for Women (Autonomous) Trichengode, Tamilnadu, India, Gayathri VR
Published: August 2022

Pseudomonas aeruginosa is a gram-negative opportunistic bacterium that is a concern worldwide due to its innate antibiotic resistance properties. This warrants the development of non-antibiotic compounds that can potentially address the growing concern. Therefore, it is of interest to document the molecular docking analysis data of three long-chain alkanes, namely, eicosane, triacontane, and nonadecane with β-lactamase BEL-1. Data shows that nonadecane have good binding features and drug-likeness when compared to triacontane and nonadecane. It is well known that nonadecane is a compound that is abundantly available from natural resources for further consideration.
Molecular docking analysis of VEGF with compounds from tomato
Authors:   Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, chengalpattu District, Tamilnadu, India, Krishnan Madhan
Published: August 2022

Vascular endothelial growth factor (VEGF) is linked with Non-small cell lung carcinoma (NSCLC). Therefore it is of interest to document data on the molecular docking analysis of VEGF with compounds from tomato for consideration drug discovery. Data shows that compounds Kaempferol-3-O, Quercetin, Naringenin & Rutin show optimal binding.
Variations in the shape of foramen magnum at the base of human skulls among Indians in Rajasthan
Authors:   Department of Anatomy, Shantabaa Medical College & General Hospital, Amreli, Gujarat 365601 India, Kumar Raj
Published: August 2022

Variations in the shape of foramen magnum can affect the normal anatomy of vital structures passing through it. Therefore, it is of interest to evaluate the various shapes of foramen magnum by using CT scans performed in patients of Indian population to establish clinical correlation. A total of 314 CT images of human skull base obtained from the Department of Radio-diagnosis, Geetanjali Medical College and Hospital, Udaipur, Rajasthan were used in the present study. All the patients’ CT scans were observed to determine the shape of foramen magnum. They were classified into one of the following shapes: Oval, round, tetragonal, egg shaped, hexagonal, pentagonal and irregular. The shapes of the foramen magnum in CT scans were oval in 39.09%, round in 22.61%, tetragonal in 12.10%, hexagonal in 10.51%, irregular in 7.96%, pentagonal in 5.41% and egg shaped in 1.59% CT images. Data shows that it is easy to operate at the base of skull in case of round, oval and hexagonal shape foramen magnum, as the working space is more in these shapes.
Naso-alveolar molding for newborn cleft lip and palate
Authors:   Department of Dentistry, Tata Main Hospital, Jamshedpur, Jharkhand, India, Breh Rohit
Published: August 2022

The nasoalveolarmolding (NAM) technique is a relatively new approach to pre-surgical infant orthopedics that reduces the severity of the initial cleft alveolar and nasal deformity before surgery. This technique has proved to be an effective adjunctive therapy for reducing cleft deformity before surgery. Data on NAM are inconsistent with changes in nasal symmetry. However, there is a trend towards a positive effect. Therefore, it is of interest to report clinicians an overview of NAM appliance and method for nasal symmetry assessment to facilitate greater usage of this technique in contemporary practice. Thus, the biomechanics of pre-surgical infant orthopedics and of nasal stent that skillfully shape alveolus and nasal cartilage is explained.
Bioinformation and Neutrino Communication
Authors:   Division of Infectious Diseases and International Health, Tampa General Hospital, Department of Internal Medicine, University of South Florida, Morsani College of Medicine, Tampa, FL 33606, USA, Shapshak Paul
Published: August 2022

Communications among civilizations may include self-descriptive bioinformation because pathogen dynamics exist in their astrobiology and astrovirology, which could become pathogenic upon actual contact. This information is of mutual benefit, if reciprocated. However, in contrast, the strategic counter-scenario of self-hidden civilizations is also discussed. Civilizations, including extra-terrestrial civilizations have been divided and stratified into three levels, using a wide non-linear logarithmic scale. The levels are based on their energy expenditures: level 1 is at 4x10^19 erg/sec; level 2 is at 4x10^33 erg/sec; and level 3 is at 4x10^44 erg/sec. Terrestrial civilization is currently below the entry level I. Particularly advanced civilizations, which are above the highest level, may engineer interstellar travel and could move their planets across interstellar distances. Communication among civilizations has always been of keen interest. In terms of ability to communicate among advanced civilizations, neutrinos may be used for galactic and inter-galactic communication, in addition to or instead of using electromagnetic radiation. Thus, at this juncture, deliberation and debate are essential to proceed with development of civilization and communication.
Correlation of serum cornitine levels with bone mineral density among Indian male tobacco users
Authors:   Buddha Institute of Dental Science And Hospital, Bihar, Patna, Chauhan Rashi ,   2Minority Dental College And Research Center, Darbhanga, Bihar, India
Published: August 2022

It is of interest to assess levels of serum cornitine in male tobacco users and also find its correlation with bone mineral density. Assessment for serum cotinine levels was done using commercially available Enzyme Linked Immunosorbent Assay (ELISA Kit). While bone mineral density was measured using bone densitometry through ultrasound in the wrist region. Karl Pearson’s coefficient was used to assess correlation between BMD values and serum cotinine (ng/ml) levels. Inter group BMD association was measured using Chi square test. The present study showed that the first 3 groups had a low BMD level compared to control group, indicative of osteopenia. BMD values were lesser for chewers from group II as compared to smokers from group I and individuals using both smoked and smokeless form of tobacco from Group III. In group III (both forms of tobacco), osteopenic individuals were more. Thus, data shows effect of tobacco usage on bone mineral density. Smokeless form of tobacco has relatively serious effects on bone density.
Professional protocol and rational outlook of dentists towards SDF
Authors:   Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India, Jabin Zohra
Published: August 2022

SDF has gained immense popularity worldwide in the recent years due to its dual performance brought about by inhibiting bacterial growth as well as promoting the remineralisation of dental hard tissues. This study aims to evaluate the knowledge and attitude among dentists towards Silver Diamine Fluoride (SDF). The present study is an online survey which was designed using Google forms, to gather information about the knowledge and professional protocol followed by dentists for SDF use in their respective operatories. Written informed consent was obtained from the participants after explaining to them the purpose of the study. The detailed questionnaire comprised of two sections. First section comprised of 15 questions which inquired about SDF knowledge and protocols followed for its use by dentists. Second section analyzed rational outlook of dentists towards SDF. Sample selection was done by simple random sampling and questionnaire Google link was circulated among 224 dentists. The mean age group of the participants is 33.82 ą 12 years. A statistically significant difference was found between the participant and the use of SDF in operatory, its application for performance in cavitated or non cavitated lesions, application intervals and the potential problems associated with SDF use. A majority of dentist (62.5%) knew that 38% concentration of SDF to be used among the children which is statistically significant. (p value ≤0.05).A lack of self-reported knowledge was most frequently reported concerning the use and application of SDF among patients to arrest carious lesions in primary and permanent teeth in a dental setting. Thus further studies can be of excellent utility especially for whole community with limited resources instead of using costly preventive strategies.
Linking leptin in GCF with tooth movement among Indians
Authors:   Department of Dentistry, Fakir Mohan Medical College, Balasore, Odisha 756019, India, Satpathy Soumyadev
Published: August 2022

It is of interest to evaluate the association of orthodontic tooth movement with concentration of leptin in Gingival Crevicular Fluid (GCF).Thirty orthodontic patients of both genders with equal sample size were included for the present study. Concentration of leptin was assessed at baseline (T0), 1 hr after application of force (T1), 24 hours later (T2), 7 days after application of force (T3), and 1 month after application of orthodontic force (T4). Using strips of filter paper, GCF was collected from the gingival sulcus on distal aspect of the right maxillary canine. Distalized tooth movement was evaluated by measuring the difference on dental casts, at baseline and one month after force application. One-way ANOVA with Bonferroni correction and Pearson's correlation test were used to analyze the data. Average concentration of leptin in GCF raises from baseline (T0) to 1 hours after application of force (T1), then increased to peak after 24 hours (T2), and declined to a minimum value after 7 days (T3) and again raises after 1 month (T4), closer to the base line value (T0), and this was statistically significant (P < 0.05). There was significant association of the overall average concentration of leptin to degree of tooth movement (correlation coefficient = 0.625). There was a biphasic change in GCF leptin concentration during one cycle of orthodontic force application, thus, a significant association between rates of tooth movement with GCF leptin concentration is noted.
Bone allograft block using demineralized freeze-dried bone ring technique in Indian patients
Authors:   Department of Periodontology, V.Y.W.S. Dental College and Hospital, Amravati, Maharashtra, India, D Yawale Pallavi
Published: August 2022

Our study aimed to evaluate the effectiveness of the bone ring technique for ridge augmentation using Demineralized Freeze – Dried Bone Allograft block in Siebert’s class II/class III defects along with simultaneous implant placement. A total of 15 partially edentulous patients (16 surgical sites) with Siebert's class II and/or class III defects in the anterior region of both jaws requiring ridge augmentation along with implant placement were selected. Starting from the first stage, surgery (Ridge augmentation+ implant placement) was done in the first month. Then, with continuous follow-ups and radiographic assessment, after 6 months of 2nd stage surgery was done, the implant was loaded with the final restoration. Significant results were revealed with all the parameters other than keratinized gingival and peri-implant mucosa thickness. With the mean bone resorption of 1.22 mm and 1.17 mm at the mesial and distal site at a 6-month interval, the success rate of the bone ring technique was 93.75%. The allograft bone ring technique showed a favorable outcome for the reconstruction of large vertical defects.
Effect of nutritional counselling for using anthropometric indices among Indians
Authors:   Department of Paediatrics, Dr. D.Y. Patil Medical College, Dr D.Y. Patil Vidyapeeth (DPU), Pimpri, Pune, Maharashtra, India, Chavan Sanjay
Published: August 2022

Malnutrition in children under 5 years is a major public health problem in developing countries. Malnutrition complex comprises of under-nutrition including multiple conditions like acute, chronic malnutrition, micronutrient deficiencies and nutrition related to obesity. Therefore, it is of interest to report data on the individualized nutritional counselling on nutritional status among mild to moderately malnourished children aged 2 – 5 years at one, three and six month follow up. Their dietary habits will help to determine the aetiology of mild/moderate malnutrition.150 Children attending outpatient department of the Department of Paediatrics of D Y Patil Medical College and admitted with mild/moderate malnutrition were included in the study after taking informed consent from their parents. The children were randomly allocated into 4 groups (group 1 – 4). The groups consisted of children where dedicated nutritional counselling was provided at 1 month, 1 and 3 month follow up and where-in no dedicated counselling was provided. A diet chart was provided with counselling. Group 4 followed up with routine care without any dietary intervention. Detailed dietary, socio economic history, clinical examination with anthropometry was done followed-up at 1, 3, 6 months from date of inclusion. Majority (57.3%) belonged to lower socio-economic class according to Kuppuswamy scale. The mean birth weight was 2.4 kg, age 34.5 months and age of weaning 7.6 months. Data shows that 70% children had mild malnutrition and 30% moderate malnutrition. At 6 month follow up amongst 105 children with mild malnutrition, 82 still had mild malnutrition, 4 normal, 19 had moderate malnutrition. Under-five childhood malnutrition is highly prevalent in poor socioeconomic strata of the society. Nutritional counselling provided by trained healthcare providers in existing settings are effective in improving nutritional status, daily calorie/protein intake, prevention of malnutrition. Prevention/treatment of co-existing illness bears equal importance.
Effectiveness of bilastine and fexofenadine among allergic Rhinitis patients in Ranchi, Jharkhand, India
Authors:   Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India, Kumari Abha
Published: August 2022

Allergic rhinitis is a worldwide health problem which impairs quality of life and interferes with daily activities. Untreated allergic rhinitis also carries a significant financial burden for the society. Bilastine, a novel second-generation antihistaminic drug that is highly selective for the H1 histamine receptor, has a rapid onset and prolonged duration of action. Thus, the aim of our study was to compare the effectiveness of bilastine and fexofenadine in treatment of allergic Rhinitis patients. 104 patients were enrolled who have fulfilled the inclusion criteria for the study from the OPD of Ear, Nose and Throat Department. Patients were divided randomly in two groups A and B. Patients of group A were allowed to take tab Bilastine 20 mg OD whereas, patients of group B were allowed to take tab. Fexofenadine Hydrochloride 120 mg OD orally for two weeks. The baseline Total Nasal Symptom Score (TNSS) were compared between two groups. The study findings showed that the mean TNSS was significantly reduced in our study group. Baseline TNSS was 13.55 and 13.45 in Group A and Group B respectively. Reduction in this parameter first become apparent in the 24 hours and maintained till 2nd week. Bilastine showed significant improvement in quality of life of Allergic rhinitis patients and proved to be more effective than fexofenadine in reducing the TNSS score, when used alone in allergic rhinitis patient.
Perception on medical ethics in teaching among medical students in India
Authors:   Department of physiology, Sri Devaraj URS medical college, Sri Devaraj Urs Academy of Higher Education and Research (deemed to be university), Tamaka, Kolar 563101, Karnataka, India, K Shetty Ashwini
Published: August 2022

The importance of teaching medical ethics has emerged as a priority in recent decades. It is of interest to document data on the perceptions of the medical students on teaching professionalism and medical ethics during the foundation course using a validated questionnaire. The Cross sectional study was conducted a Medical college in South India consisted of 150 first year MBBS Students. We received 133 responses ,40% of the students agreed that medical ethics is just a common sense, Many students (80%) agreed that the topics taught during these medical ethics sessions were relevant, easy to comprehend, teaching learning methods adopted were appropriate and they were able to participate and engage in the teaching learning activity. Majority felt that the sessions created awareness about the ethical dilemmas that might arise during patient encounters and these sessions will help them to give a justified response and agreed that these sessions made them understand the foundations of philosophical, social and legal aspects of medical ethics and also motivated them to learn more about this medical ethics .Education in medical ethics is important to practise professionally and will improve their personality skills. Suggestions given to improve ethics teaching were to increase case based discussions, reflections by the senior faculty, movie demonstrations. Students identified importance of ethics education in current day and also favoured interactive methods of teaching for the delivery of ethics related competency.
Molecular dynamics simulation analysis of the beta amyloid peptide with docked inhibitors
Authors:   Department of Biology, College of Science, University of Hail, Kingdom of Saudi Arabia, Aloufi Bandar
Published: August 2022

Beta amyloid peptide is widely studied due to its association with Alzheimer disease (AD). Various study reported that the accumulation of beta amyloid in brain cells leads to Alzheimer disease. Hence, Beta amyloid peptide could be a potential target of anti-AD therapy. Hence, it is of interest to develop potent inhibitors for Beta amyloid peptide in the context of Alzheimer disease (AD). We report the binding features of Ascorbic acid, Cysteine, Dithioerythriol, Dithiothreitol, Malic acid and α-Tocopherol with beta amyloid having binding energy values of -6.7, -6.5, -6.0, -6.5, -6.7 and - 7.0 kcal/mol respectively. The molecular docking of top-scoring compounds with beta amyloid suggests that amino acids such as ASP23, GLU22, Phe19, are crucial in binding. Molecular dynamics simulation study showed steady-state interaction of compounds with beta amyloid for further consideration.
Porta hepatis in relation to portal vein among Indians
Authors:   Department of Anatomy, Nootan medical college and Research Centre, Sankalchand Patel University, Visnagar - 384315, Gujarat, India, Gaikwad Mrinalini
Published: August 2022

The porta hepatis / hilum of liver is a transverse fissure located in the inferior surface, where the major vessels and ducts enter or leave the organ. The major structures traversing the porta hepatis are the portal vein, the hepatic artery and the hepatic duct. Porta hepatis is an area of surgical and radiological significance. The knowledge of variations in structures traversing the porta hepatitis will reduce the risk of surgeries involving this area. Study was conducted in the department of anatomy dissection lab after obtaining ethical clearance. 30 liver specimens were used for these studies which were removed from the cadaver during under graduate teaching. Anatomical knowledge of variations in relations of structures present in porta hepatis is of immense help to surgeons and radiologists when they engage patients for clinical procedures like liver transplant, cholecystectomy and diagnostic procedures. Hence this study was aimed to observe the relations of portal vein in porta hepatis.
Anti-inflammatory and cytotoxic effect of lycopene and raspberry in-situ gel
Authors:   Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India, Mukundh Chaithanya V
Published: August 2022

Preparation of an in-situ gel containing lycopene and raspberry plant formulation and analysis of its anti-inflammatory and antioxidant effects is described. Lycopene is known for its anticancer and antioxidant activity. It induces apoptosis, thereby reducing the cancer cells, and also reduces the injury of cells due to oxidative activity. Similarly, raspberry also contains antioxidants properties which can help to reduce oxidative stress and chronic inflammation. This study includes extracts containing 25% of Raspberry and 10% lycopene, carboxymethyl cellulose, hydroxypropyl methyl cellulose, Carbopol, sodium chloride, and distilled water. This in-situ gel was then tested for antioxidant and anti-inflammatory assay using DPPH (2, diphenyl 1-picryl- hydrazyl- hydrate) and bovine serum albumin (BSA), antioxidant assay revealed that the inhibition percentage was more with 50 μL (61.3) of gel and anti-inflammatory assay showed significant results with 10 μL (90.2) of gel. In-situ gel containing lycopene and Raspberry has significant anti-inflammatory and antioxidant activity.