bluuebunny/crossref_metadata_2025 huggingface dataset:
SERUM VITAMIN B12, FOLIC ACID, AND HOMOCYSTEINE LEVELS IN VITILIGO PATIENTS: A CASE-CONTROL STUDY IN KURDISTAN POPULATION
Authors: Fattah Mahdi , Saeed Mohammad
Published: December 2023

Background 
Vitiligo is an acquired depigmentation disorder that significantly impacts a patient’s quality of life. Its precise etiology is yet unknown, but it appears to be complex. Many studies have been conducted in the last decade to determine the role of hyperhomocysteinemia, vitamin B12, and folate deficiency in the etiology of vitiligo. Studying part of the aforementioned conditions may give insight into vitiligo pathogenesis.
Objectives 
To assess the contribution of homocysteine, vitamin B12, and folate in the pathogenesis of vitiligo by measuring homocysteine (Hcy), B12, and folate levels in the sera of patients and controls. as well as to see if there are a link between them and the degree of severity and duration of the vitiligo.
Patients and Methods
In the current study, 50 vitiligo patients of both sexes and 50 age and sex-matched healthy persons were recruited for six months at the Sulaimani center for skin disease treatment. Serum B12 & folate were measured using electrochemiluminescence (ECL), while serum Hcy level was measured by colorimetric technique.
Results
The mean serum levels of Hcy, B12, and folate in the healthy controls did not differ significantly from those in the patient group. (13.75- ±2.32 vs. 14.31±6.14 μmol/l; P > 0.05), (324.01±131.93 vs 311.57±110.55 pg/ml; P > 0.05), and (8.82±3.09 vs. 8.70±3.20 ng/ml P > 0.05) respectively.
Furthermore, no link was discovered between the serum levels of these parameters and the clinical types, the activity of the disease, and the duration of vitiligo. 
Conclusion
The findings don’t support the theory that homocysteine, B12, and folate are contributing factors in vitiligo etiology. Thus, screening the importance of the above mentioned factors cannot be recommended.
COMPOUND DEPRESSED SKULL FRACTURE, ITS ASSOCIATION WITH INFECTION, AND IMPORTANCE OF THE TIME FROM THE ACCIDENT
Authors: Rasheed Handren , Faraj Pakhshan
Published: December 2023

Background 

Infection can occur after compound depressed skull fracture (DSF) if not timely treated.

Objectives 

To assess the time effect from accident to surgical intervention on surgical site infection (SSI).

Patients and Methods

A retrospective cohort study was performed on 63 patients admitted to Shar Hospital from September 1, 2020, to May 13, 2021. Demographic features, type of trauma, time from accident to intervention, Glasgow Coma Scale (GCS), DSF location, associated brain injuries, dural tear, and admission to intensive trauma care unit (ITCU) were recorded. Patients followed up for 30 days.

Results

Mean±SD (standard deviation) of ages was 23.8±18.1 years, ranging from 1-70. The male-to-female ratio was (4.25:1), and patient majorities (46% and 87.3%) were workers outside the city, respectively. Patients’ ages, occupations, and residencies were significantly associated with SSI; p-values of <0.001, <0.001, and 0.004, respectively. 4.8% of patients were afflicted with SSI. Associations of admission GCS and DSF location with SSI were significant. Surgery was done for most patients (52.4%) within six hours, but the association of time from accident to surgery was non-significant. Mean±SD duration from accident to surgery was 8.1±5.1 hours, ranging from 1.5-29. All afflicted patients with SSI had basal skull fracture (BSF) and aerocele. The dural tear did not associate with SSI. All afflicted patients who underwent frontal sinus cranialization were admitted to the ITCU and significantly associated with SSI. 

Conclusion

There was no significant association between SSI occurrence and the time from the accident until surgical intervention.
ROLE OF THE FIBROSCAN IN ASSESSING CHRONIC LIVER DISEASES
Authors: Hama Ranj , Mohammed Mohammed , Mohammed Mohsin
Published: December 2023

Background 

Chronic liver disease (CLD) is a long-term inflammatory process of the liver parenchyma. In 2017 it was estimated that 1.5 billion persons had CLD, ranging from most to least common aetiology NAFLD (60%), HBV (29%), HCV (9%), and ALD (2%). The gold standard test for confirming the diagnosis, staging fibrosis, grading activity, and judging response to treatment in CLD is Liver biopsy. However, it has several limitations; as a result, validated noninvasive tests are required. Transient elastography (FibroScan; Echosens, Paris, France) is a new, non-invasive technique for measuring liver stiffness.

Objectives 

The aims of the study: To determine the role of Fibroscan in assessing fibrosis and steatosis among a group of patients with chronic liver diseases and compare Fibroscan with other noninvasive methods (APRI, NFS and FIB-4). 

Patients and Methods

This cross-sectional study was conducted on 100 patients with chronic liver disease at Kurdistan Centre for Gastroenterology and Hepatology (KCGH). Fibroscan was done in an outpatient clinic in Sulaimaniyah from June 2019- November 2020. Required data were collected from the patients based on their Clinical, laboratory and radiological findings. The collected data were analysed using Statistical Package for the Social Sciences (SPSS version 25.0).

Results

Fifty-nine percent of the patients were males. Causes of CLD among patients were as follows: 58% had hepatitis B virus infection, 18% had hepatitis C virus infection, 16% had nonalcoholic fatty liver disease, 4% had nonalcoholic steatohepatitis, 2% had alcoholic hepatitis, 1% had autoimmune hepatitis, 1% cryptogenic chronic hepatitis. The results revealed a significant association between the results obtained from Fibroscan and FIB-4 (p-value=0.001) and APRI (p-value=0.001). Moreover, the sensitivity and specificity of Fibroscan to FIB-4 were 91.2% and 26.7%, and to APRI were 82.4% and 20%. 

Conclusion

There was a significant correlation between Fibroscan and FIB-4, APRI. The degree of fibrosis by Fibroscan had a significant association with platelet (PLT) count, alkaline phosphatase (ALP) and serum albumin. There was a significant association between steatosis grades and incidence of HBV, HCV, NAFLD, NASH and , alcoholic hepatitis.
THE ROLE OF STAGING LAPAROTOMY IN GRADING GYNECOLOGICAL MALIGNANCIES
Authors: Abdulla Soma , Hussein Tahir , Mahmood Maryam
Published: December 2023

Background 

Staging laparotomy can provide optimal care for gynecological malignancies by avoiding over treatment and under treatment.

Objectives 

The aim was to explore the difference between surgical and clinical disease staging of gynecological malignancies. 

Patients and Methods

A retrospective observational study was performed on 30 women who were operated on for gynecological malignancies and were admitted to the Sulaimani Maternity Teaching Hospital from January 2019 to December 2020. Inclusion criteria included women diagnosed with gynecological malignancies before staging laparotomy. However, exclusion criteria included previous abdominal surgeries for other gynecological malignancies. In addition, demographic features, previous diagnostic methods, and intraoperative staging were recorded.

Results

The mean±SD (standard deviation) age was 51.8±14.9 years (range, 12 to 72), and the majority (56.7%) was between 50-69 years. The mean±SD of patients’ gravida and para were 4.5±3.5 (range, 0-12) and 3.4±2.8 (range, 0-8), respectively. In addition, 20% of women had a personal history (13.3%) of tumors or familial history (6.7%)—most women (50%) presented with abnormal vaginal bleeding, either postmenopausal or menstrual abnormalities. Most women with endometrial tumors (50%) had been afflicted with adenocarcinoma (endometrioid type); however, the most common types of ovarian tumors were granulosa cell tumor, papillary serous adenocarcinoma, and malignant ovarian dysgerminoma in 10%, 10%, and 6.7%, respectively. The association between clinical staging and staging laparotomy was significant. There was a 60% upgrade from a lower stage to a higher stage; however, downgrading was only 3.3%. 

Conclusion

The current study showed a significant association between clinical staging and staging laparotomy of gynecological malignancies.
SHORT AND MID-TERM MEDICAL OUTCOMES OF SLEEVE GASTRECTOMY IN OBESITY IN SULAIMANI CITY. AN ANALYTICAL CROSS-SECTIONAL STUDY
Authors: Ahmed Syamand , Abdullah Karzan , Gubarii Mohammed
Published: December 2023

Background 

The laparoscopic sleeve gastrectomy (LSG) is a frequently performed bariatric procedure. Studies indicate that LSG can facilitate successful and sustainable weight loss.

Objectives 

To examine the short-term (weight reduction) and mid-term (weight maintenance, quality of life, and medical conditions) outcomes following sleeve gastrectomy in Sulaimani.

Patients and Methods

A cross-sectional study was conducted on 114 participants from both high-quality and Zhyan hospitals in Sulaimani. From Feb 3, 2020, to Jul 22, 2021, data was gathered by evaluating the patient data records of 114 patients. Data included patients’ demographics, preoperative BMI& comorbidities, complications, and weight loss in the first week, second,4th, sixth months, and sixth months. Also, after the sixth month, complications were recorded and analyzed by SPSS software (IBM, version 25), including frequency and percentage, mean, and standard deviation, also obtained for parametric data. The associations between the variables were tested at a P value <0.05.

Results

The study consists of 114 patients (71.9% female and 28.1% male), with an average age of 34.0 years (range 20- 51 years). The average preoperative BMI and weight were 41.2 kg/m2 and 110.80 kg, respectively. Six months after surgery, the average ± SD of BMI was 32.8 kg/m ± 2 4.5, and the average ± SD of weight was 87.8 kg ±14.4. The prevalence of early postoperative problems (leak, upper GI bleeding, and intraperitoneal hemorrhage) among 114 patients was 0.9% for each complication, while the proportion of early postoperative nausea was 66.7%, and vomiting was 39.5%. Preoperative sleep apnea was 34.2%; after six months of surgery, the percentage was 0%; 19.3% of patients had joint pain; after six months of surgery, the percentage was 0.9%. In addition, 14 out of 114 patients (12.3%) had preoperative Hypertension, and 2 out of 114 patients (1.75%) had diabetes; after six months, 50% of both groups discontinued medical treatment. The incidence of gallstone development six months after surgery was 13.2%. Six months following LSG, 68.4% of individuals had hair loss. 

Conclusion

laparoscopic sleeve gastrectomy can considerably reduce BMI six months following surgery and may help improve or eliminate obesity-related comorbidities such as Hypertension and type 2 diabetes. A laparoscopic sleeve gastrectomy is an effective option for obese adults, resulting in significant weight loss with a low incidence of postoperative complications. LSG could be recommended as a valuable single intervention therapy for patients who typically fail to achieve and obtain real benefits from a structured weight loss program.
OUTCOMES OF MITCHELL’S PROCEDURE IN THE TREATMENT OF HALLUX VALGUS
Authors: Barawi Omer , Ghafour Abdullah , Muhsin Abd
Published: December 2023

Background 

Hallux Valgus is the commonest foot deformity. It is characterized by lateral deviation of the big toe with the medial shifting of the first metatarsal. Many intrinsic and extrinsic factors are claimed to be a cause and may coexist as multifactorial. Mitchell’s distal metatarsal osteotomy is one of the preliminary operations proposed in managing hallux valgus, with 70% to 90% of satisfactory results.

Objectives 

To evaluate the outcome of Mitchell’s procedure in treating mild to moderate hallux valgus in terms of clinical and radiological outcomes.

Patients and Methods

Sixteen adult patients (26 feet) with mild to moderate hallux valgus were enrolled in this study. They underwent original Mitchell’s step-cut distal osteotomy to correct their hallux valgus

Results

At the last follow-up, overall satisfaction was (81.25%) with three patients unsatisfied due to transfer metatarsagia and reflex sympathetic dystrophy. The mean change in hallux valgus angle and intermetatarsal angle were (17.27°) and (4.47°) respectively. 

Conclusion

Mitchell’s procedure is a distal metatarsal osteotomy which has good results in treating mild to moderate hallux valgus in terms of clinical and radiological appearance and acceptable patient satisfaction. However, transfer metatarsalgia and recurrence of deformity are two more known drawbacks of this procedure.
THE EFFECTS OF MATERNAL OBESITY ON MATERNAL AND NEONATAL OUTCOMES IN WOMEN WITH GESTATIONAL DIABETES
Authors: Faraj Fatima , Mahmood Maryam , Muhammad Huda , Salih Jamal
Published: December 2023

Background 

Obesity and gestational diabetes mellitus (GDM) can interfere. Poorly controlled blood glucose can cause unfavourable maternal and neonatal outcomes.

Objectives 

The study aims to know the effects of maternal obesity on maternal and neonatal outcomes in pregnant women with controlled GDM.. 

Patients and Methods

A prospective observational study was performed on 90 pregnant women with GDM admitted to Sulaimani Maternity Teaching Hospital from January 2020 to January 2021. Maternal and gestational ages, residencies, gravidity, and parity were recorded. In addition, maternal body mass index, depending on Rcog guidelines for blood glucose targets, mode of delivery, and maternal and neonatal complications were noted. Also, neonatal complications were documented, including Apgar score and body weight.

Results

Maternal ages were 34.2±6.4 years, ranging from 21 to 45. Most of them (92.3%) resided inside Sulaimani. None of the maternal outcomes had a significant association with their body weight (P-value >0.05). One woman in the obese group had intrauterine fetal death. All neonatal consequences were significantly associated with maternal body weight (P-value <0.05). 

Conclusion

The current study did not find significant associations between maternal body weights with maternal outcomes in women with controlled GDM. However, at the same time, maternal obesity has significantly increased neonatal complications.
THE EFFECTS OF OBESITY ON THE ACTIVE PHASE OF THE FIRST STAGE OF LABOR
Authors: Mahmood Dekan , Khalil Rozhan
Published: December 2023

Background 

Obesity is carrying many pregnant women now a day and has many risks for complications. There is an association between body mass index and the progression of the active phase of first-stage labor.

Objectives 

To estimate and detect obesity’s effect on the duration and progression of the active phase of labor and the outcomes of the deliveries, either by vaginal delivery or cesarean section.

Patients and Methods

A prospective observational cross-sectional study was designed and conducted at Sulaimani maternity teaching hospital in Sulaimani City. From 1st February 2020 to 1st February 2021, about labor study included the progression of 184 multiparous women (para1-4) with a single vertex presentation from (37+1 to 41+6) weeks of complete gestation. Either by spontaneous or induction labor (misoprostol or oxytocin). Between four groups, defined by body mass index according to the world health organization. Normal (n=88), over weight (n=3), obesity class 1(n=43), obesity class 2(n=50)

Results

A total of 184 patients were collected in this study. The mean ± SD (standard deviation) age/year of participants was (27, 49 ±5.54 SD) minimum age was 17 years, and the maximum age was 44 years. A high percentage of them (51.6%) were living in urban. About (27.2%) were classified as obesity class 2, which carries a high percentage of cases that ends by cesarean section C/S (n=9) 81.8%, with prolonged duration of active phase by mean (4.988) and standard deviation (1.9302) in comparison with other classes. 

Conclusion

The duration of the active phase of labor, cesarean section rate, and the time for induction until the active phase of labor were increased by increasing body mass index.
An evolutionary view of foresight in the field of artificial intelligence
Authors: Elkhova Oksana I. , Kudryashev Alexander F.
Published: December 2023

The article analyzes the task of scientific foresight in the field of artificial intelligence (AI) and assesses the possibility of predicting AI development in the coming decades. Based on an evolutionary model of AI, the authors hypothesize that AI fits into the evolutionary development of humans. Drawing on the ideas of nomogenesis, first introduced by biologist L.S. Berg in 1922, they argue that embracing the concept of stable evolutionary patterns creates a fundamental possibility to predict a certain range of forthcoming changes as a result. The question of transferring the function of foresight from humans to AI is also examined, particularly in areas of science and technology where decision-making necessitates complex analysis of future potential outcomes. Strong arguments are presented in favor of the possibility of predicting AI development in principle, although with some degree of probability. This optimistic view aligns with researchers across various domains of human activity in which AI has already found or will yet find its application.
Post-non-classical modification of techno anthropology E. Kappa
Authors: Loiko Alexander I.
Published: December 2023

The article studies the evolution of techno-anthropology in the modifications of the classical, non-classical and post-non-classical periods of philosophical reflection on the example of the projection of human organs by E. Kapp. The reasons for the actualization of the design theory of human organs by E. Kapp in post-non-classical philosophy are described. The categorical apparatus of the post-non-classical philosophy of technology is analyzed. In the semantics of the post-non-classical philosophy of technology, a tendency for the dominance of technological determinism has been revealed. The situation of transformation of the paradigm of anthropocentrism into competing paradigms by modern man is stated. One of them is formulated as a paradigm of the creative disappearance of a person. The second paradigm is positioned as a strategy for the spatial expansion of a distributed human body, hybrid integrity, assembly and assemblages.
Cultural and technical progress in a sociogenetic perspective
Authors: Cheshev Vladislav V.
Published: December 2023

The correlation of cultural and technical progress is considered as a manifestation of subject-active and behavioral principles in sociogenesis. Both factors of the sociogenetic process have relative autonomy, uniting in the systemic organization of society. The relevance of addressing the essence of cultural progress, which manifests itself in sociogenesis as the development of specific universal principles of behavior, appearing as the universal foundations of morality, is pointed out.
Values of the Domostroevsky cultural tradition
Authors: Tyugashev Evgeny A.
Published: December 2023

The article presents a toxicological characteristic of the Domostroevsky cultural tradition as one of the main traditions that determine the civilizational development of Russia. The main values of this tradition are livability, good partnership, prudence, domesticity, a clear conscience.
Education and upbringing as phenomena of European culture: classic, post-classical, and post-post-classical contexts
Authors: Mojeiko Marina A.
Published: December 2023

Cultural modifications of the phenomenon of education, its priority role in classical culture, deformations of education and upbringing in postmodern culture and new intentions of post-post-non-classical culture in their interpretation are considered.
Bricolage and the «Fluid Identity» of Postmodernism
Authors: Lemiashova Tatyana V.
Published: December 2023

This article explores the postmodern concept of «fluid identity». In contrast to the classical understanding of stable personal identity, the article presents postmodern tendencies that emphasize the instability and fragmentation of identity. The key features of this idea are elucidated, such as the deconstruction and loss of the core of identity, the pluralism and multiplicity of identities, and the influence of digital technologies on identity formation and expression. The concept of bricolage by Claude Lévi-Strauss is positioned as a mechanism that explains the process of creating a «fluid identity». The shift from established paradigms to a more flexible and individual way of perceiving and expressing identity in the contemporary world is noted.
Mathematical Modelling and Experimentation of Soy Wax 68℃ Encapsulated into Solar Tank (Case Study)
Authors: Ghabour Rajab , Amer Yacoub , Korzenszky Péter Emőd
Published: December 2023

Governments worldwide are attempting to minimise CO2 emissions, and solar energy storage remains the most difficult problem to tackle in the current climate. Typically, domestic hot water is mainly used for heat process services in colder climates when the tank loss is significant. Any design modification can result in a higher solar yield. Since water is a perfect medium for heat storage, this article will examine different Solar Domestic Hot Water (SDHW) systems in cold climates such as Central Europe and hot and dry climates such as the Middle East (Syria). Linear modelling was conducted using R script software using coded values to define the optimal value using the response surface method (RSM). The programming phase uses the least-squares approach to provide a general rationale for the line's best-match position among the data points under consideration. For each variable, the coded values range from [-1, +1]. The number of experiments is determined by the formula 2k , where k is the variable number. Since each variable has two possible values [-1, +1], the total number of experiments was 23= 8. In addition to these experiments, we performed one more experiment for defining second-degree non-linear coefficients. The second-degree factors were checked to evaluate the non-linearity of the system. The experimental work was done in the laboratory; an insulated water tank filled with 5 litres of water was used. A capsulated PCM soy wax 68℃ test was conducted. For the charging phase, the response surface approach with non-linear correlation was used to determine the optimal number of samples and PCM quantity at two temperature levels. The results of temperature, sample numbers, and wax quantity demonstrate a 0.22, 2.3, and -1.12 first-degree magnitude effect, respectively. In addition, each two-factor interaction contour plot is depicted.
THE CONCEPT OF «WARRIOR» IN THE LINGUISTIC WORLD VIEW OF UKRAINE AND SPAIN IN THE 21st CENTURY
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Smorokova Elina
Published: December 2023

The article provides an in-depth examination of the evolving concept of “warrior” during Russian aggression in Ukraine. It highlights the paramount importance of cognitive linguistics in unravelling the ways in which language shapes and is shaped by our beliefs, particularly in times of social and political unrest. Based on an analysis of Ukrainian and Spanish media, this study highlights the significant impact of cultural and cognitive frameworks on the communication of concepts in language. This understanding provides an essential basis for a comprehensive study of the development of the concept in different cultural and linguistic contexts. The research definitively establishes the importance of cultural influences in shaping linguistic expressions and, consequently, worldviews and ideologies. It also reinforces the idea that language is not just a means of communication, but a powerful tool for propaganda, persuasion, and the construction of national identities. The use of Ukrainian and Spanish media as analytical focal points allows for a cross-cultural and cross-linguistic comparison, enhancing our understanding of how the notion of a 'warrior' is perceived and represented in these unique contexts. The article offers an insightful perspective that sheds light on the complex interplay between language, culture and evolving social dynamics.
LEXICAL AND SEMANTIC VARIABILITY OF THE SPANISH LANGUAGE AS A PLOT CHARACTERISTIC IN MODERN CINEMA
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Popova Nataliia , Hryhorash Daria ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: December 2023

The article examines the role of lexical invariants found in Spanish-language feature films and television series produced in different countries. The article analyzes the impact of lexical and semantic variants of language units on the understanding and perception of plots by viewers. It is determined that the viewer's recognition of Spanish and Latin American equivalents, regional dialects, argot and jargon can broaden the intercultural framework of communication, deepen the knowledge of the historical, social, cultural and historical realities of a certain nation. Semantic differences in lexemes affect the plot of films, while lexicographic differences create unique images of characters in the viewers' minds. Metaphorical transfers and phraseology specific to a particular culture add deep axiological and cultural meaning to the plot. The authenticity and cultural context of Spanish-language films, reflected in the lexical and semantic features of the characters' speech, expand viewers’ communicative and linguistic competence in the modern globalized world. The aim of the study is to determine the role of lexical and semantic differences in the dialogues of Spanish-language films and to characterize their impact on their perception, creation of images and characters, as well as on the cultural exchange between Spanish-speaking countries and other cultures through the cinema. The study focuses on lexemes, phrases, metaphors, phraseological units and microtexts that differ in their lexicography or semantic content in Spanish and Latin American films. Semantic and contextual analysis of the linguistic material has been conducted to identify those differences. The methods used by the film industry to adapt films to their target audiences have also been identified. However, the comparison shows a simplification of the plot interpretation and a loss of regional authentic characteristics through the use of language adaptation. It has been found that interculturalism can contribute to the society globalization without losing cultural values through the inclusion of contextual explanations in film dialogues.
Electronic Tranding Platform and Data Flow
Authors: Latipova Nodira
Published: December 2023

This article discusses the features and trends of process of development and creation of a multi-functional electronic trading platform is aimed at efficient and profitable interaction of suppliers and buyers. Interaction takes place through electronic communication systems, so it is always operative and relevant. Electronic trading platform is a complex of information and modern technical solutions. There are several types of electronic trading platforms - for commercial customers, for placing government orders. The sites on which electronic transactions are performed by commercial customers are divided into specialized and multi-profile. Users, participants of the sites, held auctions and trades themselves can decide on which of the sites it is more convenient and profitable to work with. In addition, on a multiprofile resource the customer can act as a supplier, the seller - this is dependent on the scope of his activities, on the possibilities.
Cross-Cultural Adaptation and Validation of the Russian-Language Version of the American Orthopaedic Foot and Ankle Society Ankle-Hindfoot Scale (AOFAS-AHS)
Authors: Fomichev Viktor A. , Sorokin Evgenii P. , Konovalchuk Nikita S. , Pashkova Ekaterina A. , Sereda Andrey P.
Published: December 2023

Background. Developed in 1994 by H. Kitaoka et al. the American Orthopaedic Foot and Ankle Society Ankle-Hindfoot scale (AOFAS-AHS) allows to assess pain, function, deformity and alignment of the foot and ankle. There is no Russian-language AOFAS-AHS questionnaire adapted according to current standards in the scientific literature.
The aim of this paper is to perform the cross-cultural adaptation and to assess the validity of the Russian-language version of the AOFAS-AHS scale, including the evaluation of its psychometric properties.
Methods. The original English version of the AOFAS-AHS scale was translated from English into Russian by a native Russian speaker. Then the questionnaire was back-translated into English by another translator whose native language is English. The next stage was the comparison of the original and back-translated versions, followed by the presentation of a pre-final cross-culturally adapted version, which was tested on 10 patients to ensure that the questions were comprehensible. The next step was the approval of the final version and its completion by patients to be operated on the hindfoot or ankle. The printed copy of the final version of the questionnaire was completed by the patients with an interval of 3 days. Total of 44 consecutive patients were enrolled, including 18 women (41%) and 26 men (59%), with a mean age of 61.7 (32-78) years. The psychometric properties of the Russian-language version of the AOFAS-AHS questionnaire (internal consistency, retest reliability, measurement error, responsiveness, and construct validity) were assessed based on the COSMIN (COnsensus-based Standards for the selection of health status Measurement INstruments) principles.
Results. The mean score according to the AOFAS-AHS scale was 49.6 (min 2; max 82) out of a possible 100. The average time to complete the questionnaire was 4.2 minutes. All hypotheses formulated showed correlations of varying moderate to strong degrees. The Cronbach’s alpha coefficient was 0.76, which indicates a high level of internal consistency of the elements of the validated questionnaire. A good intra-class consistency of 0.83 was obtained, which shows a high degree of reliability of the questionnaire’s reproducibility. The ceiling and floor effects for the primary results of the questionnaires did not exceed 15%. The mean value of the Russian-language version of the AOFAS-AHS increased to 86.6 after surgical treatment. The values of standardized effect size (ES) and standardized response mean (SRM) were 5.56 and 4.83, respectively.
Conclusion. The adapted Russian-language version of the AOFAS-AHS scale showed good psychometric properties and can be recommended for assessment of the physical activity in patients with ankle and hindfoot-related pathology and can also be used for monitoring the changes during the treatment.
Dermatofibrosarcoma protuberans: Under the mask of scar
Authors: Vertieva Ekaterina Yu. , Kayumova Lyailya N. , Bobkova Anna E.
Published: December 2023

Dermatofibrosarcoma protuberans (Darier–Ferrand) is a rare mesenchymal tumor of fibrohistiocytic genesis with moderate malignancy and low incidence of metastasis, the pathogenesis and etiology of which remain unclear. The diagnosis is based on the clinical picture of a reddish-brown dense plaque or papule that gradually becomes a painful node with ulceration. Histological examination reveals the infiltrate with a moire pattern in the dermis in the form of fusiform cells with diffuse CD34+ staining during immunohistochemical analysis. Treatment of dermatofibrosarcoma protuberans (Darier–Ferrand) is a serious problem due to the high tendency for recurrence after removal. The methods described in the literature include extensive excision, Mohs surgery, chemotherapy, radiation therapy and targeted treatment with an anticancer protein-tyrosine kinase inhibitor.
The authors present their own clinical observation of a patient with dermatofibrosarcoma protuberans (Darier–Ferrand) in whom a diagnostic error by only visual method and an incorrect treatment led to the worsening of skin process. The interest of this clinical observation lies in the difficulty of diagnosis during the initial visit, in the complexity of differential and morphological diagnosis.
Experience of using the interleukin-17A inhibitor secukinumab in the treatment of psoriasis and psoriatic arthritis
Authors: Molochkova Yulia Vladimirovna , Petrova Marina S. , Molochkov Vladimir A. , Monaenkova Maria K. , Abalukhova Elizaveta D.
Published: December 2023

Psoriasis is a chronic immune-inflammatory skin disease, which in 25–30% of cases occurs in combination with damage of the musculoskeletal system ― psoriatic arthritis. Nowadays, the leading role in the pathogenesis of psoriasis and psoriatic arthritis is assigned to the activation of the IL-23/IL-17 axis-key cytokines involved in the activation pathway of the effector activity of Th17 lymphocytes. The activity of proinflammatory cytokines secreted by Th17 cells in psoriasis and psoriatic arthritis is also confirmed by the high efficiency of targeted therapy aimed specifically at this pathway. One of the modern genetically engineered biological drugs blocking IL-17 which is used worldwide in the treatment of psoriasis and psoriatic arthritis is secukinumab, a recombinant, fully human monoclonal antibody of high affinity directed against IL-17A.
The article presents data from own 52-week follow-up of secukinumab use in 40 patients with severe and moderate-severe psoriasis which was combined with psoriatic arthritis in 67.5% of cases and demonstrates high efficacy, survival and satisfactory tolerability of this therapy.
Human papillomavirus and its association with oral lichen planus
Authors: Starshinina Victoria A. , Perlamutrov Yuri N. , Olhovskaya Kira B.
Published: December 2023

BACKGROUND: Oral lichen planus is a chronic disease with periods of exacerbations and remissions, requiring long-term symptomatic treatment and observation. Dermatosis can occur or worsen in the presence of different triggers, for example, due to the persistence of the human papillomavirus.
AIM: to explore the effect human papillomavirus on the characteristics oral lichen planus.
MATERIALS AND METHODS: 90 patients with oral lichen planus aged from 26 to 73 years (average age 55.61±1.00 years) were examined. Real-time polymerase chain reaction was used to detect human papillomavirus. The need for treatment of caries, Green–Vermillion and complex periodontal indices were used to analysis state of oral hygiene.
RESULTS: Human papillomavirus DNA was detected in 53 (58.88%) cases. Patients of this group were 4 years younger than other study participants; the duration of dermatosis is 2 years longer with a predominance of atrophic/erythematous and erosive/ulcerative forms. It was noted that indexes of caries and the complex periodontal were significantly (p=0,007 and p=0,030 respectively) higher compared to patients without papillomavirus infection.
CONCLUSION: It is found features of oral lichen planus in identifying human papillomavirus: early onset; severe of the disease with predominantly destructive forms; high prevalence of caries and periodontitis.
Chronicles of A.I. Pospelov Moscow Society of Dermatovenerologists and Cosmetologists (MSDC was founded on October 4, 1891). Bulletin of the MSDC meeting N 1154
Authors: Yakovlev Alexey B. , Maximov Ivan S.
Published: December 2023

On October 17, 2023, the 1154th meeting of the Moscow Society of Dermatovenerologists and Cosmetologists named after A.I. Pospelov took place.
The meeting was held in a face-to-face format. There were 118 participants in total. 65 applications were submitted for membership in MSDC! Due to the large number of applicants for membership in the MSDC, a list vote was held: approved unanimously.
Two reports were presented in the clinical part of the meeting: Pityriasis rubra pilaris after suffering COVID-19 (Sechenov University); A clinical case of a rare hereditary disease ― erythrokeratoderma (State Scientific Center of Dermatovenereology and Cosmetology).
Reports were made in the scientific part of the meeting: Topical therapy for xerosis of various genesis (Sechenov University); Modern paradigms for improving the effectiveness of treatment of allergodermatoses taking into account violations of the skin microbiome (Federal Scientific and Clinical Center of Intensive Care and Rehabilitation); The use of transcranial electrical stimulation in patients with atopic dermatitis (Sechenov University).
On the role and perspectives of diagnostic improvement of infectious diseases in forensic medical practice
Authors: Burdova Elena Y. , Minaeva Polina V. , Kozhevnikova Galina M.
Published: December 2023

Postmortem verification of an infectious disease in forensic medical practice is crucial in solving several problems faced by both the doctor conducting the examination and healthcare system, from the regional to the international level. This review presents an analysis of scientific studies on the possibilities of postmortem diagnosis of infectious diseases. Foreign and domestic experience of forensic doctors in conditions of the threat and spread of highly contagious diseases and emerging infections is shown, as well as an overview of approaches to organizing safe working environment in the forensic medical examination bureau.
Rapid Source Characterization of the 2023 Mw 6.8 Al Haouz, Morocco, Earthquake
Authors: Yeck William L. , Hatem Alexandra E. , Goldberg Dara E. , Barnhart William D. , Jobe Jessica A. Thompson , Shelly David R. , Villaseñor Antonio , Benz Harley M. , Earle Paul S.
Published: December 2023

The U.S. Geological Survey (USGS) National Earthquake Information Center (NEIC) estimates source characteristics of significant damaging earthquakes, aiming to place events within their seismotectonic framework. Contextualizing the 8 September 2023, Mw 6.8 Al Haouz, Morocco, earthquake is challenging, because it occurred in an enigmatic region of active surface faulting, and low seismicity yet produced significant damage and loss of life. Here, we present the rapid earthquake source products produced by the USGS NEIC, describing how the source model was derived using both seismic and geodetic observations. Our analysis indicates that the earthquake was the result of oblique-reverse faulting in the lower crust on either a steeply north-dipping fault or a moderately south-dipping fault. Finite-slip models using seismic and geodetic data reveal a compact source, with slip occurring at depths of 15–35 km. The causative fault is not apparent, because the rupture did not break the surface, and it is not possible to definitively attribute the earthquake to a known structure. The earthquake centroid depth of 25 km is noteworthy, because it shows slip extending beyond common estimates of seismogenic depth. This earthquake highlights that the seismogenic processes associated with mountain building in this wide plate boundary region are poorly understood.
Determinación clásica de la energía del punto cero para diferentes sistemas radiantes
Authors: González Sierra Hernando , Mendoza Suárez Jairo Alonso , Sandoval Solano Laura Daniela
Published: December 2023

En este artículo se evalúa la energía electromagnética del punto cero, sin emplear la conceptualización usual de cuerpo negro y asociando una longitud característica o longitud lineal para el oscilador de una cavidad (sin usar argumentos de cuantización). Se determina la energía del punto cero para diversos sistemas radiantes reales, estableciendo que esta depende de un parámetro , que es del orden de la constante reducida de Planck ℏ.
Modificación de silla pélvica con dispositivo de apoyo al freno para descenso en personal del Ejército Nacional de Colombia
Authors: Rojas González Juan Gabriel , Díaz Tovar Jorh Alexánder , Hernández García Mónica Estefanía , Barrero García Julián Enrique B , Tarazona Rojas Nathalie
Published: December 2023

El presente artículo de investigación surge del proyecto “Silla pélvica modificada con dispositivo de apoyo al freno para descenso”, que se realiza con base en las experiencias de contingencias presentadas en el primer hombre al momento de descender en la torre de Asalto Aéreo del Ejército Nacional de Colombia, con el fin de reducir el riesgo de accidentalidad del usuario a partir de la implementando un dispositivo de freno, que consiste en la adaptación de un mosquetón ubicado en un punto específico (parte lateral pierna izquierda o derecha) de la silla pélvica, el cual es un punto fijo con adaptabilidad y seguridad de anclaje. Esto le permite al oficial continuar con sus y da orientación y control a la cuerda, evitando nudos por oscilación al soltar la cuerda de freno
Acute Myocardial Infarction Due to Myocardial Bridge Treated With Surgery: a Case Report
Authors: Açar Burak , Torun Akin , Celikyurt Umut , Talas Zeki , Yavuz Sadan
Published: December 2023

Myocardial bridging is congenital anomaly characterized by segment of epicardial coronary arteries passing through the myocardium. Various ischemic conditions are related with this pathology. We report a case of myocardial bridging that was complicated with acute anterior myocardial infarction and a review of the literature. The patient was treated successfully with coronary bypass graft surgery after unsuccessful percutaneous intervention.
Effect of the Prognostic Nutrition Index on Long-Term Outcomes in Unprotected Left Main Coronary Artery Revascularization
Authors: Güzel Tuncay , Avcı Eyüp , Kırış Tuncay , Arık Baran , Arslan Bayram , İldırımlı Kamran , Yıldırım Bünyamin , Argun Lokman , Demir Muhammed , Aktan Adem , Özbek Mehmet , Aslan Burhan , Gitmez Mesut , Karaçalılar Mehmet , Çakır Çayan , Kılıç Raif , Ertaş Faruk
Published: December 2023

Objective    The prognostic nutritional index (PNI) is a practical, applicable, prognostic scoring system. However, its clinical significance in unprotected left main coronary artery (ULMCA) patients undergoing percutaneous coronary intervention (PCI) has not yet been clarified. This study aimed to examine the relationship between malnutrition as assessed by PNI and major adverse cardiac events (MACE) in ULMCA patients undergoing PCI.Material and methods    185 patients who were hospitalized in our clinic underwent coronary angiography, had a critical LMCA lesion, and underwent angiography-guided PCI were included. The study population was divided into tertiles based on the PNI values. A high PNI (n=142) was defined as a value in the third tertile (≥ 34.0), and a low PNI (n=43) was defined as a value in the lower 2 tertiles (< 34.0). The primary endpoint was MACE.Results    MACE and mortality rates in the low PNI group were significantly higher compared to the high PNI group (51 % vs. 30 %, p=0.009; 44 % vs. 20 %, p=0.002, respectively). High PNI (HR:1.902; 95 % CI:1.112-3.254; p=0.019), previous stroke (HR:3.025; 95 % CI:1.038-8.810; p=0.042) and SYNTAX score (HR:1.028; 95 % CI:1.004-1.057, p=0.023) were independent predictors of MACE in the multivariable cox regression analyzes.Conclusions    In patients undergoing ULMCA PCI, nutritional status can be considered an indicator of MACE rates by evaluating the PNI score. This index can be used for risk classification.
Metabolic Blood Hormones in Young People With Electrocardiographic Signs of Ischemic Myocardial Changes
Authors: Stakhneva E. M. , Kuzminykh N. A. , Scherbakova L. V. , Kashtanova E. V. , Polonskaya Ya. V. , Shramko V. S. , Garbuzova (Striukova) E. V. , Sadovski E. V. , Ragino Yu. I.
Published: December 2023

Aim    To study changes in blood concentrations of metabolic hormones and adipocytokines in people aged 25-44 years with electrocardiographic (ECG) signs of ischemic changes in the myocardium.Material and methods This study was a part of a cross-sectional survey of a random sample of Novosibirsk population aged 25-44 years. The study included 1363 people divided into two groups: group 1, subjects with ECG signs of ischemic changes in the myocardium and group 2, subjects without ECG changes. Blood serum concentrations of adipocytokines and metabolic hormones were measured by multiplex assay on a Luminex MAGPIX flow-through fluorometer.Results    The group with ECG signs of myocardial ischemia had higher blood concentrations of adiponectin, resistin, glucagon, and interleukin 6 (IL-6) than in the comparison group. A multivariate logistic regression analysis showed that the glucagon concentration was associated with the presence of ECG signs of myocardial ischemia (OR, 1.019; CI, 1.018-1.034; p=0.017).Conclusion    In young people aged 25-44 years, higher blood concentrations of glucagon are associated with the presence of ECG signs of myocardial ischemia.
Retrospective Analysis of Lipid-Lowering and Antiplatelet Therapy Regimen by Clinical Decision Support Service Based on Real-World Data from Electronic Medical Records “Intellect 3 Study”
Authors: Benimetskaya K. S. , Provatorov S. I. , Ezhov  M. V. , Krivosheev Y. S. , Gavrilko A. D. , Uranov A. E. , Mikheenko I. L. , Kovalev E. A. , Ponomarenko A. V. , Shangina A. M. , Efremova Yu. E. , Kolmakova T. E. , Matveeva M. A. , Dolgusheva Yu. A. , Alekseeva I. A. , Osokina A. K. , Nozadze D. N. , Atyunina I. V. , Paleev F. N. , Meshkova M. A. , Sharapova Yu. A. , Losik D. V.
Published: December 2023

Aim      To evaluate prescription of lipid-lowering and antithrombotic therapy in clinical practice and to compare differences in recommendations using the clinical decision support service (CDSS).

Material and methods  Electronic medical records (EMR) of 300 patients from the Chazov National Medical Research Center of Cardiology, as well as from medical organizations controlled by the Department of Health of the Lipetsk Region and the Ministry of Health of the Voronezh Region, were analyzed for the period of August - December 2022, during the pilot implementation of CDSS. Retrospective information about the prescription of lipid-lowering and antithrombotic therapy from the EMR was compared with the CDSS guidelines under the expert supervision based on digitized clinical and laboratory profiles of patients. The study primary endpoint was a change in the initially prescribed lipid-lowering and / or antithrombotic therapy as per CDSS guidelines.

ResultsOverall 292 patients were included in the final analysis; 46 (15.7 %) were from the primary prevention group and 246 (84.3 %) from the secondary prevention group. In group 1, the lipid-lowering therapy recommended by the CDSS differed by 50 % (p<0.001) from the baseline therapy recorded in the EMR. In the secondary prevention group, 78.9 % (p<0.001) differences were found in the lipid-lowering therapy recommended in the CDSS guidelines compared to the prescriptions in the EMR. In 76.8 % (p<0.001) of patients, antithrombotic therapy was significantly different from the baseline therapy in the EMR.

Conclusion      The use of CDSS may improve the practice of choosing lipid-lowering and antithrombotic therapy for prevention of cardiovascular complications.
The pittsburg sleep quality index in asthmatic patients: A case-control study
Authors: Ghods Elahe
Published: December 2023

Introduction: Sleep disturbances are common in asthmatic patients. The purpose of this study was to evaluate sleep quality in asthmatic patients in local setting. Materials and methods: In the present case-conrol study, sleep quality of asthma patients was assessed using Pittsburgh Sleep Quality Index (PSQI), in 76 clinically stable asthmatic patients at the outpatient clinic compared to 76 healthy subjects in control group. Poor sleep quality is classified as PSQI score more than 5. Results: Mean PSQI score in patients was significanly higher than the control group. The number and percent of cases with poor sleep quality and all subdomains of PSQI score were statistically more than control group. Conclusion: According to the results of the present study, sleep quality of the majority of asthma patients was not desirable. It is necessary for policy makers and health managers as well as physicians to focus on this aspect of the patients’ health as well. It is recommended to have sleep health consultation in pulmonary clinic.