bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-Term Effects and Potential Impact of Early Nutrition with Breast Milk or Infant Formula on Glucose Homeostasis Control in Healthy Children at 6 Years Old: A Follow-Up from the COGNIS Study
Authors: Diéguez Estefanía , Nieto-Ruiz Ana , Sepúlveda-Valbuena Natalia , Herrmann Florian , Agil Ahmad , De-Castellar Roser , Jiménez Jesús , Azaryah Hatim , García-Santos José Antonio , García-Bermúdez Mercedes , Campoy Cristina
Published: February 2023

There is scarce evidence about early nutrition programming of dynamic aspects of glucose homeostasis. We analyzed the long-term effects of early nutrition on glycemic variability in healthy children. A total of 92 children participating in the COGNIS study were considered for this analysis, who were fed with: a standard infant formula (SF, n = 32), an experimental formula (EF, n = 32), supplemented with milk fat globule membrane (MFGM) components, long-chain polyunsaturated fatty acids (LC-PUFAs), and synbiotics, or were breastfed (BF, n = 28). At 6 years old, BF children had lower mean glucose levels and higher multiscale sample entropy (MSE) compared to those fed with SF. No differences in MSE were found between EF and BF groups. Normal and slow weight gain velocity during the first 6 months of life were associated with higher MSE at 6 years, suggesting an early programming effect against later metabolic disorders, thus similarly to what we observed in breastfed children. Conclusion: According to our results, BF and normal/slow weight gain velocity during early life seem to protect against glucose homeostasis dysregulation at 6 years old. EF shows functional similarities to BF regarding children’s glucose variability. The detection of glucose dysregulation in healthy children would help to develop strategies to prevent the onset of metabolic disorders in adulthood.
Prevalence, Risk Factors and Impact of Nutrition Interruptions in Critically Ill Children
Authors: Solana María José , Slocker María , Martínez de Compañon Zuriñe , Olmedilla Marta , Miñambres María , Reyes Susana , Fernández Reyes , Rodríguez Eva , Redondo Silvia , Díaz Laura , Sánchez María , López-Herce Jesús
Published: February 2023

Background: Enteral nutrition interruptions (ENI) are prevalent in the pediatric intensive care unit (PICU), but there is little evidence of their characteristics. Methods: This is a cross-sectional multicenter study including critically ill children on enteral nutrition. ENIs were classified as PICU procedures, procedures performed outside the PICU (PPOP), feeding intolerance and other criteria. The number and features of ENIs were collected. Results: A total of 75 children were enrolled. There were 41 interruptions affecting 37.3% of the patients with a median duration of 5 ± 9.4 h. The most common reason for ENI was PPOP (41.5%), followed by other criteria. Interruptions were considered preventable in 24.4% of the cases, but only eight were compensated. ENIs were more prevalent among children with cardiac disease (p = 0.047), higher PRISM (p = 0.047) and longer PICU stay (p = 0.035). There was association between PRISM and total interruption time (p = 0.02) and lower caloric intake (p = 0.035). Patients with respiratory illness (p = 0.022) and on noninvasive ventilation (p = 0,028) had fewer ENIs. ENI total time was associated with lower caloric (p = 0.001) and protein (p = 0.02) intake. Conclusions: ENIs are prevalent in PICU, especially in children with higher PRISM, longer PICU stays and cardiac disease, and result in lower caloric and protein intake.
Can Ordering Groceries Online Support Diet Quality in Adults Who Live in Low Food Access and Low-Income Environments?
Authors: Avelino Daniela C. , Duffy Valerie B. , Puglisi Michael , Ray Snehaa , Lituma-Solis Brenda , Nosal Briana M. , Madore Matthew , Chun Ock K.
Published: February 2023

During the COVID-19 pandemic, U.S. food assistance programs allowed the use of program benefits to order groceries online. We examined relationships between the food environment, food assistance, online grocery ordering, and diet quality among adults from one low-income, low food access community in Northeastern Connecticut during the pandemic. Via online survey, adults (n = 276) reported their perceived home and store food environments, food assistance participation, whether they ordered groceries online, and consumption frequency and liking of foods/beverages to calculate diet quality indices. Those who ordered groceries online (44.6%) were more likely to participate in food assistance programs and report greater diet quality. Perceived healthiness of store and home food environments was variable, with the ease of obtaining and selecting unhealthy foods in the neighborhood significantly greater than healthy foods. Healthier perceived home food environments were associated with significantly higher diet qualities, especially among individuals who participated in multiple food assistance programs. Ordering groceries online interacted with multiple measures of the food environment to influence diet quality. Generally, the poorest diet quality was observed among individuals who perceived their store and home food environments as least healthy and who did not order groceries online. Thus, ordering groceries online may support higher diet quality among adults who can use their food assistance for purchasing groceries online and who live in low-income, low-access food environments.
Movement of Chronic Wasting Disease Prions in Prairie, Boreal and Alpine Soils
Authors: Kuznetsova Alsu , McKenzie Debbie , Ytrehus Bjørnar , Utaaker Kjersti Selstad , Aiken Judd M.
Published: February 2023

Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy negatively impacting cervids on three continents. Soil can serve as a reservoir for horizontal transmission of CWD by interaction with the infectious prion protein (PrPCWD) shed by diseased individuals and from infected carcasses. We investigated the pathways for PrPCWD migration in soil profiles using lab-scale soil columns, comparing PrPCWD migration through pure soil minerals (quartz, illite and montmorillonite), and diverse soils from boreal (Luvisol, Brunisol) and prairie (Chernozem) regions. We analyzed the leachate of the soil columns by immunoblot and protein misfolding cyclic amplification (PMCA) and detected PrP in the leachates of columns composed of quartz, illite, Luvisol and Brunisol. Animal bioassay confirmed the presence of CWD infectivity in the leachates from quartz, illite and Luvisol columns. Leachates from columns with montmorillonite and prairie Chernozems did not contain PrP detectable by immunoblotting or PMCA; bioassay confirmed that the Chernozemic leachate was not infectious. Analysis of the solid phase of the columns confirmed the migration of PrP to lower layers in the illite column, while the strongest signal in the montmorillonite column remained close to the surface. Montmorillonite, the prevalent clay mineral in prairie soils, has the strongest prion binding ability; by contrast, illite, the main clay mineral in northern boreal and tundra soils, does not bind prions significantly. This suggests that in soils of North American CWD-endemic regions (Chernozems), PrPCWD would remain on the soil surface due to avid binding to montmorillonite. In boreal Luvisols and mountain Brunisols, prions that pass through the leaf litter will continue to move through the soil mineral horizon, becoming less bioavailable. In light-textured soils where quartz is a dominant mineral, the majority of the infectious prions will move through the soil profile. Local soil properties may consequently determine the efficiency of environmental transmission of CWD.
The Dangerous Side of Being a Predator: Toxoplasma gondii and Neospora caninum in Birds of Prey
Authors: Zanet Stefania , Veronesi Fabrizia , Giglia Giuseppe , Baptista Carolina Raquel Pinto , Morganti Giulia , Mandara Maria Teresa , Vada Rachele , De Carvalho Luis Manuel Madeira , Ferroglio Ezio
Published: February 2023

Toxoplasma gondii and Neospora caninum are apicomplexan protozoa of major concern in livestock and T. gondii is also considered one of the major threats and a public health concern. These protozoa have a wide range of intermediate hosts, including birds. The present work aimed to assess the prevalence of these cyst-forming parasites in migratory and sedentary birds of prey. The skeletal muscle and myocardium of 159 birds of prey from Central Italy, belonging to 19 species and recovered across 6 Wildlife Recovery Centers/Care structures along the Italian migratory route, were collected specifically for molecular (PCR) and for histopathological analysis to detect T. gondii and N. caninum. For the molecular analysis, genomic DNA was extracted. The DNA was tested by sequence typing, targeting GRA6, 529 bp repeated element, B1, PK1, BTUB, SAG2, alt.SAG2, and APICO genes for T. gondii and to end-point PCR targeting NC5 gene for N. caninum. Thirty-seven out of the one hundred and fifty-nine analyzed samples tested positive for T. gondii with a prevalence of 23.27% and nine for N. caninum, with a prevalence of 5.66%. Thirty-two sequences were obtained from the thirty-seven isolates of T. gondii. Among these, 26 presented alleles compatible with type I strain in 1 or more loci, 4 with type II strain and 2 consisted of atypical strains. Toxoplasma gondii genetic variability in birds of prey confirms previous findings of wildlife as reservoirs of atypical strains. Results from the histology showed few protozoal tissue cysts in skeletal muscle (n. 4) and hearts (n. 2).
Can Resveratrol Influence the Activity of 11β-Hydroxysteroid Dehydrogenase Type 1? A Combined In Silico and In Vivo Study
Authors: Novak Jurica , Tseilikman Vadim E. , Tseilikman Olga B. , Lazuko Svetlana S. , Belyeva Lyudmila E. , Rahmani Azam , Fedotova Julia
Published: February 2023

The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) is an NADPH-dependent reductase, responsible for the activation of cortisol by reducing cortisone. Resveratrol (RES), a type of natural polyphenol, is reported to be able to slow the progression of cancer and cardiovascular disease and improve the health of mice on a high-calorie diet. In this article, we applied molecular docking and molecular dynamics simulations to investigate the possibility of binding RES to 11β-HSD-1. The 11β-HSD-1:RES complex is stable on the μs time scale, and backbone RMSD-based clustering identified three conformations. Special attention was paid to the interaction pattern between the ligand and the target molecule, revealing hydrogen bonds between the hydroxyl group of RES and Thr124, as well as hydrophobic interactions responsible for the binding. In vivo studies demonstrated the ability of resveratrol at a dose of 40 mg/kg to reduce 11β-HSD-1 activity in the liver of rats under conditions of experimental post-traumatic stress disorder (PTSD), as well as in non-stressed animals. In both cases, the resveratrol-induced reduction in 11β-HSD-1 activity was accompanied by an increase in plasma corticosterone levels and a decrease in anxiety levels in the plus maze test.
An Understanding of Mechanism-Based Approaches for 1,3,4-Oxadiazole Scaffolds as Cytotoxic Agents and Enzyme Inhibitors
Authors: Kumar Davinder , Aggarwal Navidha , Deep Aakash , Kumar Harsh , Chopra Hitesh , Marwaha Rakesh Kumar , Cavalu Simona
Published: February 2023

The world’s health system is plagued by cancer and a worldwide effort is underway to find new drugs to treat cancer. There has been a significant improvement in understanding the pathogenesis of cancer, but it remains one of the leading causes of death. The imperative 1,3,4-oxadiazole scaffold possesses a wide variety of biological activities, particularly for cancer treatment. In the development of novel 1,3,4-oxadiazole-based drugs, structural modifications are important to ensure high cytotoxicity towards malignant cells. These structural modification strategies have shown promising results when combined with outstanding oxadiazole scaffolds, which selectively interact with nucleic acids, enzymes, and globular proteins. A variety of mechanisms, such as the inhibition of growth factors, enzymes, and kinases, contribute to their antiproliferative effects. The activity of different 1,3,4-oxadiazole conjugates were tested on the different cell lines of different types of cancer. It is demonstrated that 1,3,4-oxadiazole hybridization with other anticancer pharmacophores have different mechanisms of action by targeting various enzymes (thymidylate synthase, HDAC, topoisomerase II, telomerase, thymidine phosphorylase) and many of the proteins that contribute to cancer cell proliferation. The focus of this review is to highlight the anticancer potential, molecular docking, and SAR studies of 1,3,4-oxadiazole derivatives by inhibiting specific cancer biological targets, such as inhibiting telomerase activity, HDAC, thymidylate synthase, and the thymidine phosphorylase enzyme. The purpose of this review is to summarize recent developments and discoveries in the field of anticancer drugs using 1,3,4-oxadiazoles.
Correction: Rashid et al. Natural Compounds of Lasia spinosa (L.) Stem Potentiate Antidiabetic Actions by Regulating Diabetes and Diabetes-Related Biochemical and Cellular Indexes. Pharmaceuticals 2022, 15, 1466
Authors: Rashid Md. Mamunur , Rahman Md. Atiar , Islam Md. Shahidul , Hossen Md. Amjad , Ahmed A. M. Abu , Afroze Mirola , Habib Alaa H. , Mansoury Manal M. S. , Alharbi Hend F. , Algheshairy Reham M. , Alelwani Walla , Alnajeebi Afnan M. , Tangpong Jitbanjong , Saha Srabonti , Qadhi Alaa , Azhar Wedad
Published: February 2023

In the published publication [...]
Fabrication of Celecoxib PVP Microparticles Stabilized by Gelucire 48/16 via Electrospraying for Enhanced Anti-Inflammatory Action
Authors: Alshawwa Samar Zuhair , El-Masry Thanaa A. , Elekhnawy Engy , Alotaibi Hadil Faris , Sallam Al-Sayed , Abdelkader Dalia H.
Published: February 2023

Electrospraying (ES) technology is considered an efficient micro/nanoparticle fabrication technique with controlled dimensions and diverse morphology. Gelurice® 48/16 (GLR) has been employed to stabilize the aqueous dispersion of Celecoxib (CXB) for enhancing its solubility and oral bioavailability. Our formula is composed of CXB loaded in polyvinylpyllodine (PVP) stabilized with GLR to formulate microparticles (MPs) (CXB-GLR-PVP MPs). CXB-GLR-PVP MPs display excellent in vitro properties regarding particle size (548 ± 10.23 nm), zeta potential (−20.21 ± 2.45 mV), and drug loading (DL, 1.98 ± 0.059 mg per 10 mg MPs). CXB-GLR-PVP MPs showed a significant (p < 0.05) higher % cumulative release after ten minutes (50.31 ± 4.36) compared to free CXB (10.63 ± 2.89). CXB exhibited good dispersibility, proved by X-ray diffractometry (XRD), adequate compatibility of all components, confirmed by Fourier-Transform Infrared Spectroscopy (FTIR), and spherical geometry as revealed in scanning electron microscopy (SEM). Concerning our anti-inflammatory study, there was a significant decrease in the scores of the inflammatory markers’ immunostaining in the CXB-GLR-PVP MPs treated group. Also, the amounts of the oxidative stress biomarkers, as well as mRNA expression of interleukins (IL-1β and IL-6), considerably declined (p < 0.05) in CXB-GLR-PVP MPs treated group alongside an enhancement in the histological features was revealed. CXB-GLR-PVP MPs is an up-and-coming delivery system that could be elucidated in future clinical investigations.
Thermophilic Exopolysaccharide Films: A Potential Device for Local Antibiotic Delivery
Authors: Laubach Joseph M. , Sani Rajesh K.
Published: February 2023

Natural polysaccharides being investigated for use in the field of drug delivery commonly require the addition of sugars or pretreated biomass for fabrication. Geobacillus sp. strain WSUCF1 is a thermophile capable of secreting natural polymers, termed exopolysaccharides (EPSs), cultivated from cost-effective, non-treated lignocellulosic biomass carbon substrates. This preliminary investigation explores the capabilities of a 5% wt/wt amikacin-loaded film constructed from the crude EPS extracted from the strain WSUCF1. Film samples were seen to be non-cytotoxic to human keratinocytes and human skin-tissue fibroblasts, maintaining cell viability, on average, above 85% for keratinocytes over 72-h during a cell viability assay. The drug release profile of a whole film sample revealed a steady release of the antibiotic up to 12 h. The amikacin eluted by the EPS film was seen to be active against Staphylococcus aureus, maintaining above a 91% growth inhibition over a period of 48 h. Overall, this study demonstrates that a 5% amikacin-EPS film, grown from lignocellulosic biomass, can be a viable option for preventing or combating infections in clinical treatment.
In situ Formation of Polymer Microparticles in Bacterial Nanocellulose Using Alternative and Sustainable Solvents to Incorporate Lipophilic Drugs
Authors: Bellmann Tom , Thamm Jana , Beekmann Uwe , Kralisch Dana , Fischer Dagmar
Published: February 2023

Bacterial nanocellulose has been widely investigated in drug delivery, but the incorporation of lipophilic drugs and controlling release kinetics still remain a challenge. The inclusion of polymer particles to encapsulate drugs could address both problems but is reported sparely. In the present study, a formulation approach based on in situ precipitation of poly(lactic-co-glycolic acid) within bacterial nanocellulose was developed using and comparing the conventional solvent N-methyl-2-pyrrolidone and the alternative solvents poly(ethylene glycol), CyreneTM and ethyl lactate. Using the best-performing solvents N-methyl-2-pyrrolidone and ethyl lactate, their fast diffusion during phase inversion led to the formation of homogenously distributed polymer microparticles with average diameters between 2.0 and 6.6 µm within the cellulose matrix. Despite polymer inclusion, the water absorption value of the material still remained at ~50% of the original value and the material was able to release 32 g/100 cm2 of the bound water. Mechanical characteristics were not impaired compared to the native material. The process was suitable for encapsulating the highly lipophilic drugs cannabidiol and 3-O-acetyl-11-keto-β-boswellic acid and enabled their sustained release with zero order kinetics over up to 10 days. Conclusively, controlled drug release for highly lipophilic compounds within bacterial nanocellulose could be achieved using sustainable solvents for preparation.
Nanoparticles for Lymph Node-Directed Delivery
Authors: Lee Jaeseong , Kang Sungtaek , Park Hyeseon , Sun Jeong Gil , Kim Eun Chae , Shim Gayong
Published: February 2023

Lymph nodes are organs that control immune cells and provide a major pathway for primary tumors to metastasize. A nanoparticles-based strategy has several advantages that make it suitable for achieving effective lymphatic delivery. First, the size of nanoparticles can be tailored to meet a size range appropriate for lymphatic migration. In addition, functionalized nanoparticles can target cells of interest for delivery of drugs or imaging probes. Existing lymph node contrast agents map all lymph nodes regardless of metastasis status; however, by using nanoparticles, it is possible to selectively target lymphatic metastases. Moreover, using functionalized nanoparticles, it is possible to specifically deliver anticancer drugs to metastatic lymph nodes. In this review, we introduce the use of nanoparticles for lymphatic mapping, in particular highlighting design considerations for detecting metastatic lymph nodes. Furthermore, we assess trends in lymph node-targeting nanoparticles in clinical practice and suggest future directions for lymph node-targeting nanoparticles.
Effect of Carbon Nanofibers on the Viscoelastic Response of Epoxy Resins
Authors: Santos Paulo , Silva Abílio P. , Reis Paulo N. B.
Published: February 2023

Two epoxy resins with different viscosities were enhanced up to 1 wt.%, applying a simple method with carbon nanofibers (CNFs). These were characterized in terms of static bending stress, stress relaxation, and creep tests. In bending, the contents of 0.5 wt.% and 0.75 wt.% of CNFs on Ebalta and Sicomin epoxies, respectively, promote higher relative bending stress (above 11.5% for both) and elastic modulus (13.1% for Sicomin and 16.2% for Ebalta). This highest bending stress and modulus occurs for the lower viscosity resin (Ebalta) due to its interfacial strength and dispersibility of the fillers. Creep behaviour and stress relaxation for three stress levels (20, 50, and 80 MPa) show the benefits obtained with the addition of CNFs, which act as a network that contributes to the immobility of the polymer chains. A long-term experiment of up to 100 h was successfully applied to fit the Kohlrausch–Williams–Watts (KWW) and Findley models to stress relaxation and creep behaviour with very good accuracy.
Hybrid Microcapsules for Encapsulation and Controlled Release of Rosemary Essential Oil
Authors: Berraaouan Doha , Essifi Kamal , Addi Mohamed , Hano Christophe , Fauconnier Marie-Laure , Tahani Abdesselam
Published: February 2023

The foremost objective of this work is to assess the microcapsules composition (polymer-based and polymer/clay-based) effect, on the release of rosemary essential oil into w/o medium and evaluate their antioxidant activity. Calcium alginate (CA) and calcium alginate/montmorillonite hybrid (CA-MTN) microcapsules were developed following an ionotropic crosslinking gelation and were used as host materials for the encapsulation of rosemary essential oil. The unloaded/loaded CA and hybrid CA-MTN microcapsules were characterized by Fourier transform infra-red (FT-ATR) spectroscopy, thermal analysis (TGA), scanning electron microscopy (SEM) and DPPH assay. The evaluation of the microcapsule’s physicochemical properties has shown that the clay filling with montmorillonite improved the microcapsule’s properties. The encapsulation efficiency improved significantly in hybrid CA-MTN microcapsules and exhibited higher values ranging from 81 for CA to 83% for hybrid CA-MTN and a loading capacity of 71 for CA and 73% for hybrid CA-MTN, owing to the large adsorption capacity of the sodic clay. Moreover, the hybrid CA-MTN microcapsules showed a time-extended release of rosemary essential oil compared to CA microcapsules. Finally, the DPPH assay displayed a higher reduction of free radicals in hybrid CA-MNT-REO (12.8%) than CA-REO (10%) loaded microcapsules. These results proved that the clay–alginate combination provides microcapsules with enhanced properties compared to the polymer-based microcapsules.
Impact of Isonicotinic Acid Blending in Chitosan/Polyvinyl Alcohol on Ripening-Dependent Changes of Green Stage Tomato
Authors: Taher Mohamed A. , Elsherbiny Elsherbiny A.
Published: February 2023

The effect of isonicotinic acid (INA) in a chitosan (CS)/polyvinyl alcohol (PVA) blend on ripening-dependent changes of preserved green tomatoes (Solanum lycopersicum L.) was examined at room temperature. The results showed that CS/PVA/INA 0.5 mM and CS/PVA/INA 1.0 mM formulations retarded firmness loss and delayed the pigmentation parameters i.e., lycopene (LYP), total carotenes (TCs), and titratable acidity (TA). The CS/PVA/INA 0.5 mM and CS/PVA/INA 1.0 mM formulations were able to delay the increase in malondialdehyde (MDA) and total polyphenol (TP) contents. Furthermore, the peroxidase (POD), polyphenoloxidase (PPO), and phenylalanine ammonia-lyase (PAL) activities of tomatoes coated with CS/PVA/INA 0.5 mM and CS/PVA/INA 1.0 mM formulations were lower than those in other treatments. Meanwhile, the CS/PVA blend had the highest TP content, as well as the highest PPO and PAL activities, at the late stage of maturation. The UV analysis showed that the CS/PVA/INA blend film is a promising UV-protective food packaging material. The pure CS, PVA, and INA formulations, as well as the CS/PVA, CS/PVA/INA 0.5 mM, and CS/PVA/INA 1.0 mM formulations, were characterized by infrared (FTIR). The three polymer formulations showed strong antifungal activity against Alternaria alternata and Botrytis cinerea.
The Influence of Fiber on the Mechanical Properties of Geopolymer Concrete: A Review
Authors: Wang Tao , Fan Xiangqian , Gao Changsheng , Qu Chiyu , Liu Jueding , Yu Guanghui
Published: February 2023

Geopolymer is widely used as a supplement to cementitious composites because of its advantages of low carbon and environmental protection, and geopolymer concrete is also broadly used in practical engineering. In recent years, geopolymer concrete has attracted increasing interest owing to its superior mechanical properties, and a series of research results have been obtained. In this paper, from the preparation of geopolymer concrete, based on the characteristics that geopolymer concrete is brittle and easy to crack, the types and basic properties of fibers to enhance the toughness of concrete are analyzed, the advantages and disadvantages of different fibers used as a material to enhance the toughness of concrete are summarized, and we review the effects of type, shape, volume rate, aspect ratio, and hybrid fiber combinations on the static mechanical properties. The results indicate that fibers have significant potential to enhance the compressive strength, splitting tensile strength, flexural strength, and fracture toughness of geopolymer concrete, and the optimal fiber volume rate seems to be related to the fiber type. Whereas the effect of aspect ratio and hybrid fiber combinations on the properties of geopolymer concrete seems to be obvious. This paper reviews the influence of fiber on the basic mechanical properties of geopolymer concrete, which provides a solid foundation to promote the further development and application of the research on the toughness of fiber-reinforced geopolymer concrete and provides recommendations for future research.
Recent Advances in Lignocellulose-Based Monomers and Their Polymerization
Authors: Pei Fuyun , Liu Lijuan , Zhu Huie , Guo Haixin
Published: February 2023

Replacing fossil-based polymers with renewable bio-based polymers is one of the most promising ways to solve the environmental issues and climate change we human beings are facing. The production of new lignocellulose-based polymers involves five steps, including (1) fractionation of lignocellulose into cellulose, hemicellulose, and lignin; (2) depolymerization of the fractionated cellulose, hemicellulose, and lignin into carbohydrates and aromatic compounds; (3) catalytic or thermal conversion of the depolymerized carbohydrates and aromatic compounds to platform chemicals; (4) further conversion of the platform chemicals to the desired bio-based monomers; (5) polymerization of the above monomers to bio-based polymers by suitable polymerization methods. This review article will focus on the progress of bio-based monomers derived from lignocellulose, in particular the preparation of bio-based monomers from 5-hydroxymethylfurfural (5-HMF) and vanillin, and their polymerization methods. The latest research progress and application scenarios of related bio-based polymeric materials will be also discussed, as well as future trends in bio-based polymers.
Biological Characteristics of Polyurethane-Based Bone-Replacement Materials
Authors: Egorikhina Marfa N. , Bokov Andrey E. , Charykova Irina N. , Rubtsova Yulia P. , Linkova Daria D. , Kobyakova Irina I. , Farafontova Ekaterina A. , Kalinina Svetlana Ya. , Kolmogorov Yuri N. , Aleynik Diana Ya.
Published: February 2023

A study is presented on four polymers of the polyurethane family, obtained using a two-stage process. The first composition is the basic polymer; the others differ from it by the presence of a variety of fillers, introduced to provide radiopacity. The fillers used were 15% bismuth oxide (Composition 2), 15% tantalum pentoxide (Composition 3), or 15% zirconium oxide (Composition 4). Using a test culture of human fibroblasts enabled the level of cytotoxicity of the compositions to be determined by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay, along with variations in the characteristics of the cells resulting from their culture directly on the specimens. The condition of cells on the surfaces of the specimens was assessed using fluorescence microscopy. It was shown that introducing 15% bismuth, tantalum, or zinc compounds as fillers produced a range of effects on the biological characteristics of the compositions. With the different fillers, the levels of toxicity differed and the cells’ proliferative activity or adhesion was affected. However, in general, all the studied compositions may be considered cytocompatible in respect of their biological characteristics and are promising for further development as bases for bone-substituting materials. The results obtained also open up prospects for further investigations of polyurethane compounds.
4D Printing of Electroactive Triple-Shape Composites
Authors: Razzaq Muhammad Yasar , Gonzalez-Gutierrez Joamin , Farhan Muhammad , Das Rohan , Ruch David , Westermann Stephan , Schmidt Daniel F.
Published: February 2023

Triple-shape polymers can memorize two independent shapes during a controlled recovery process. This work reports the 4D printing of electro-active triple-shape composites based on thermoplastic blends. Composite blends comprising polyester urethane (PEU), polylactic acid (PLA), and multiwall carbon nanotubes (MWCNTs) as conductive fillers were prepared by conventional melt processing methods. Morphological analysis of the composites revealed a phase separated morphology with aggregates of MWCNTs uniformly dispersed in the blend. Thermal analysis showed two different transition temperatures based on the melting point of the crystallizable switching domain of the PEU (Tm~50 ± 1 °C) and the glass transition temperature of amorphous PLA (Tg~61 ± 1 °C). The composites were suitable for 3D printing by fused filament fabrication (FFF). 3D models based on single or multiple materials were printed to demonstrate and quantify the triple-shape effect. The resulting parts were subjected to resistive heating by passing electric current at different voltages. The printed demonstrators were programmed by a thermo-mechanical programming procedure and the triple-shape effect was realized by increasing the voltage in a stepwise fashion. The 3D printing of such electroactive composites paves the way for more complex shapes with defined geometries and novel methods for triggering shape memory, with potential applications in space, robotics, and actuation technologies.
Nanoparticles Based on Chondroitin Sulfate from Tuna Heads and Chitooligosaccharides for Enhanced Water Solubility and Sustained Release of Curcumin
Authors: Waiprib Yaowapha , Ingrungruengluet Pattarachat , Worawattanamateekul Wanchai
Published: February 2023

This study aimed to separate chondroitin sulfate (CS) from the heads of skipjack tuna (Katsuwonus pelamis) and yellowfin tuna (Thunnus albacares), by-products derived from canned tuna processing, via a biological process. The use of 1% w/w papain and an incubation time of 48 h resulted in a degree of hydrolysis of 93.75 ± 2.94% and a CS content of 59.53 ± 1.77 mg/100 g. The FTIR spectra of extracted CS products exhibited identical functional groups found in commercially available CS. The molecular weights of CS extracted from skipjack and yellowfin tuna heads were 11.0 kDa and 7.7 kDa, respectively. Subsequently, a CH:CS ratio of 3:2 for CS and chitooligosaccharides (CH) was chosen as the optimal ratio for the preparation of spherical nanoparticles, with %EE, mean particle size, PDI, and zeta potential values of 50.89 ± 0.66%, 128.90 ± 3.29 nm, 0.27 ± 0.04, and −12.47 ± 2.06, respectively. The CU content was enhanced to 127.21 ± 1.66 μg/mL. The release of CU from this particular nanosystem involved mainly a drug diffusion mechanism, with a burst release in the first 3 h followed by a sustained release of CU over 24 h. The DPPH and ABTS scavenging activity results confirmed the efficient encapsulation of CU into CHCS nanoparticles. This study will provide a theoretical basis for CS derived from tuna head cartilages to be used as a functional component with specific functional properties in food and biomedical applications.
Research on Low-Velocity Impact Response of Novel Short-Fiber-Reinforced Composite Laminates
Authors: Huang Yinyuan , EShun Felix Thompson , Hu Junfeng , Zhang Xutong , Zhao Jianping , Zhang Siqi , Qian Rui , Chen Zhou , Chen Dingding
Published: February 2023

Short-fiber-reinforced polymers (SFRPs) based on unidirectionally arrayed chopped strands (UACSs) have excellent formability and outstanding mechanical response. The low-velocity impact response, such as the delamination, damage tolerance and energy absorption of UACS composites, are essential to guarantee the stability and safety of composite components in service. The current study investigates the low-velocity impact response of continuous carbon-fiber-reinforced polymer (CFRP) and UACS laminates with vertical slits under drop-weight impact with various impact energies (4, 7 and 11 J). The in-plane size of the studied samples is 100 mm × 100 mm, and the stacking sequence is [0/90]4s. The time–history curves of load and energy are examined during low-velocity impact experiments, as well as the nonvisible damages are obtained by ultrasound C-scan imaging technique. A user-defined subroutine VUMAT, including the Johnson–Cook material and failure model, which is used to simulate the elastic–plastic property of the slits filled with resin, is coded in ABAQUS/Explicit. According to C-scan inspections of the impact-damaged laminates, UACS specimens show more severe delamination as impact energy increases. The damaged area of continuous CFRP laminates under impact energy of 11 J is 311 mm2, while that of UACS laminates is 1230 mm2. The slits have a negative effect on the load-bearing capacity but increase the energy absorption of UACS laminates by approximately 80% compared to the continuous CFRP laminates at 7 J. According to the variables of different damage modes in numerical simulation, cracks appear at the slits and then expand along the direction perpendicular to the slits, leading to the fracture of fiber. Nevertheless, as the damage expands to the slits, the delamination confines the damage propagation. The existence of slits could guide the path of damage propagation.
A Rapid Quantitative Analysis of Bicomponent Fibers Based on Cross-Sectional In-Situ Observation
Authors: Qin Jieyao , Lu Mingxi , Li Bin , Li Xiaorui , You Guangming , Tan Linjian , Zhai Yikui , Huang Meilin , Wu Yingzhu
Published: February 2023

To accelerate the industrialization of bicomponent fibers, fiber-based flexible devices, and other technical fibers and to protect the property rights of inventors, it is necessary to develop fast, economical, and easy-to-test methods to provide some guidance for formulating relevant testing standards. A quantitative method based on cross-sectional in-situ observation and image processing was developed in this study. First, the cross-sections of the fibers were rapidly prepared by the non-embedding method. Then, transmission and reflection metallographic microscopes were used for in-situ observation and to capture the cross-section images of fibers. This in-situ observation allows for the rapid identification of the type and spatial distribution structure of the bicomponent fiber. Finally, the mass percentage content of each component was calculated rapidly by AI software according to its density, cross-section area, and total test samples of each component. By comparing the ultra-depth of field microscope, differential scanning calorimetry (DSC), and chemical dissolution method, the quantitative analysis was fast, accurate, economical, simple to operate, energy-saving, and environmentally friendly. This method will be widely used in the intelligent qualitative identification and quantitative analysis of bicomponent fibers, fiber-based flexible devices, and blended textiles.
Prediction of Stress–Strain Curves for HFRP Composite Confined Brick Aggregate Concrete under Axial Load
Authors: Saingam Panumas , Ejaz Ali , Ali Nazam , Nawaz Adnan , Hussain Qudeer , Joyklad Panuwat
Published: February 2023

Recently, hemp-fiber-reinforced polymer (HFRP) composites have been developed to enhance the strength and ductility of normal and lightweight aggregate concrete along with recycled brick aggregate concrete. In addition, both experimental and analytical investigations have been performed to assess the suitability of the existing strength and strain models. However, the theoretical and analytical expressions to predict the stress–strain curves of HFRP-confined concrete were not developed. Therefore, the main objective of this study was to develop analytical expressions to predict the stress–strain curves of HFRP-confined waste brick aggregate concrete. For this purpose, a new experimental framework was conducted to examine the effectiveness of HFRP in improving the mechanical properties of concrete constructed with recycled brick aggregates. Depending on the strength of the concrete, two groups were formed, i.e., Type-1 concrete and Type-2 concrete. A total of sixteen samples were tested. The ultimate compressive strength and strain significantly increased due to HFRP confinement. Improvements of up to 272% and 457% in the ultimate compressive strength and strain were observed due to hemp confinement, respectively. To predict the ultimate compressive strength and strain of HFRP-confined concrete, this study investigated several existing analytical stress–strain models. Some of the strength models resulted in close agreement with experimental results, but none of the models could accurately predict the ultimate confined strain. Nonlinear regression analysis was conducted to propose expressions to predict the ultimate compressive strength and strain of HFRP-confined concrete. The proposed expressions resulted in good agreement with experimental results. An analytical procedure was proposed to predict the stress–strain curves of hemp-confined concrete constructed by partial replacement of natural coarse aggregates by recycled fired-clay brick aggregates. A close agreement was found between the experimental and analytically predicted stress–strain curves.
Study on Thermal Degradation Processes of Polyethylene Terephthalate Microplastics Using the Kinetics and Artificial Neural Networks Models
Authors: Chowdhury Tanzin , Wang Qingyue
Published: February 2023

Because of its slow rate of disintegration, plastic debris has steadily risen over time and contributed to a host of environmental issues. Recycling the world’s increasing debris has taken on critical importance. Pyrolysis is one of the most practical techniques for recycling plastic because of its intrinsic qualities and environmental friendliness. For scale-up and reactor design, an understanding of the degradation process is essential. Using one model-free kinetic approach (Friedman) and two model-fitting kinetic methods (Arrhenius and Coats-Redfern), the thermal degradation of Polyethylene Terephthalate (PET) microplastics at heating rates of 10, 20, and 30 °C/min was examined in this work. Additionally, a powerful artificial neural network (ANN) model was created to forecast the heat deterioration of PET MPs. At various heating rates, the TG and DTG thermograms from the PET MPs degradation revealed the same patterns and trends. This showed that the heating rates do not impact the decomposition processes. The Friedman model showed activation energy values ranging from 3.31 to 8.79 kJ/mol. The average activation energy value was 1278.88 kJ/mol from the Arrhenius model, while, from the Coats-Redfern model, the average was 1.05 × 104 kJ/mol. The thermodynamics of the degradation process of the PET MPs by thermal treatment were all non-spontaneous and endergonic, and energy was absorbed for the degradation. It was discovered that an ANN, with a two-layer hidden architecture, was the most effective network for predicting the output variable (mass loss%) with a regression coefficient value of (0.951–1.0).
Alternative to Detecting Changes in the Mean of an Autoregressive Fractionally Integrated Process with Exponential White Noise Running on the Modified EWMA Control Chart
Authors: Peerajit Wilasinee , Areepong Yupaporn
Published: February 2023

The modified exponentially weighted moving-average (modified EWMA) control chart is an improvement on the traditional EWMA control chart. Herein, we provide more details about the modified EWMA control chart using various values of an additional design parameter for detecting small-to-moderate shifts in the process mean of an autoregressive fractionally integrated (ARFI(p, d)) process with exponential white noise running thereon. The statistical performances of the two charts were evaluated in terms of the average run length (ARL) obtained by solving integral equations (IEs). This provides an exact formula with proven existence and uniqueness verified by applying Banach’s fixed-point theorem. The accuracy of the proposed formula for the ARL was compared with the ARL derived by using the numerical IE technique for the out-of-control state. Although their accuracies were identical for various out-of-control situations and long-term memory processes, the exact formula method required less than 0.01 s to compute the ARL whereas the numerical IE method took 3–4 s. The strengths of using the exact formula are that it is simple to calculate and the computational time is significantly reduced. Comparing their standard deviations of the run length and median run lengths yielded the same results. Finally, practical examples with real-life data corresponding to ARFI(p, d) processes with exponential white noise are provided to demonstrate the applicability of the proposed exact formula.
A Techno-Economic Study of Catalytic Decarboxylation Process for Naphthenic Acids Utilizing Protonic Zeolite Socony Mobil Type 5 (HZSM-5) Catalyst
Authors: Hassan Nihad Omer , Ibrahim Gasim , Beshir Dhallia Mamoun , Elbashir Nimir O.
Published: February 2023

This paper represents a detailed techno-economic analysis of a typical commercial-scale catalytic decarboxylation process of naphthenic acids over HZSM-5 zeolite. Simulation of the process has been performed in ASPEN Plus®. The performance of the modeled unit was compared to experimental results data from a similar plant. Two models were developed for the proposed industrial plant based on continuous flow reactors; the first is based on a fluidized bed reactor, and it was modeled as a continuous stirred tank reactor (CSTR) unit, and the second is a semi-regenerative process that consists of three fixed-bed reactors with intermediate preheaters and are modeled as three plug flow reactors (PFR). The outcome of the economic analysis of the two proposed commercial scale reactors of a decarboxylation process of a capacity of 11,000 bbl/day showed that the CAPEX, including the total equipment cost for the fluidized bed reactor plant and semi-regenerative process plant, was $44,319,362 and $4,447,919, respectively. The annual operating cost for the fluidized bed plant and semi-regenerative process plant is 45,269,180 $/year and 1,771,839 $/year, respectively. Our results demonstrated that catalytic decarboxylation over HZSM-5 zeolite is economically feasible using a semi-regenerative process, and is a promising method for removing naphthenic acid. The insight obtained from this work can be used as a basis for more comprehensive future financial and risk modeling of the process. The cost estimated in this work was compared to the Khartoum refinery cost for the naphthenic acid corrosion mitigation system, with a saving of $29,459,528.
Reflecting on Teaching Practice: Adopting Islamic Liberatory Pedagogies within Muslim Institutes of Higher Education in UK (MIHEUK)
Authors: Suddahazai Imran Hussain Khan
Published: February 2023

The aim of this paper is to discuss the practice of Islamically informed liberatory pedagogical practice within a MIHEUK, through a ‘self-reflective’ dialogue. As the former course leader for Education Studies at the Markfield Institute of Higher Education, the paper examines the derived reflections and experience of the author teaching the BA degree program in Islamic studies with Education and the MA Post-Graduate Degree program in Islamic Education (2019–2022). In contributing to the discussion, the paper adopts a critically reflective interpretivist–hermeneutical methodology, whereby Fazlur Rahman’s double hermeneutical model is utilised to contextualise core educational principles from the Islamic weltanschauung (1982). The paper cites an example exercise study utilised to analyse the adoption of Islamically informed liberatory pedagogical practices. The findings from this exercise reveal that the students’ general ability to critically reflect upon the Islamic educational tradition reflect the influence of the teacher. However, the increased ability of the students to act independently and think critically to challenge the limits to their own potential or understanding of the sources dictating their religiosities and subjectivities is from a place of authenticity, thereby demonstrating the transformative nature of self-realisation as conscientization (critical consciousness) and its realisation of latent potentialities.
Religious Singing in Kashubia: Tradition and Modernity
Authors: Perszon Jan
Published: February 2023

The article answers the question of how the custom of religious singing was created in Kashubia and constitutes an integral part of the worship of the Church and local piety/religiosity until modern times. Nowadays, musical worship is manifested both in family and rural life (religious singing at home, May devotions, Rosary prayer services, vigil for the dead) as well as in ecclesial sphere (church services, Calvary celebrations, feasts, processions, and pilgrimages). It integrates local communities and simultaneously “broadens” their relationship with the sacred (God). It is important to present the process of selecting leaders of folk singing, as there is no institutional support in this matter such as music schools, organ courses or choirs. It can be assumed that, as was the case in the nineteenth and twentieth centuries, the family tradition plays a decisive role in leading and animating collective singing. The changes which are taking place in this respect now require further research and may be the result of the transformations in the field of folk religious singing in Kashubia, which are the consequence of the dynamic social transformation in this region. This study is based on ethnographic field research conducted by the author in 2016–2021 and the literature on the subject.
Adversarial Remote Sensing Scene Classification Based on Lie Group Feature Learning
Authors: Xu Chengjun , Shu Jingqian , Zhu Guobin
Published: February 2023

Convolutional Neural Networks have been widely used in remote sensing scene classification. Since this kind of model needs a large number of training samples containing data category information, a Generative Adversarial Network (GAN) is usually used to address the problem of lack of samples. However, GAN mainly generates scene data samples that do not contain category information. To address this problem, a novel supervised adversarial Lie Group feature learning network is proposed. In the case of limited data samples, the model can effectively generate data samples with category information. There are two main differences between our method and the traditional GAN. First, our model takes category information and data samples as the input of the model and optimizes the constraint of category information in the loss function, so that data samples containing category information can be generated. Secondly, the object scale sample generation strategy is introduced, which can generate data samples of different scales and ensure that the generated data samples contain richer feature information. After large-scale experiments on two publicly available and challenging datasets, it is found that our method can achieve better scene classification accuracy even with limited data samples.