bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Semiotika Iklan Aqua Kids 2020
Authors: Marsheilo Bryan , Tamburian Daniel
Published: March 2022

Advertising is a complex form of communication that is useful for influencing the thoughts, feelings and actions of consumers for the benefit of advertisers, advertising is a form of communication that has a complex message because it has signs in the ad, signs can be anything in the advertisement. Aqua is the largest bottled drinking water company for the last 5 years, and has created a new advertisement that has made a new focus for consumers, namely children, due to the COVID-19 pandemic. This is interesting to research because drinking water is a product that can be consumed by all ages, but Aqua decided to create a new segment in its products, therefore its new advertisement must have many signs to convey to potential consumers, thus requiring semiotic techniques. . Semiotics is a study that studies signs and what is associated with signs. This research is a qualitative study using the semiotic analysis method of Roland Barthes, collecting data by observing Aqua Kids advertisements. The researcher takes the scenes in the advertisement and identifies the signs and messages in each scene, with connotative and denotative. The results showed that children had difficulty concentrating in online learning activities, but when Aqua kids were there, the problem disappeared, and made mothers happy with the child's presentation.Periklanan adalah bentuk komunikasi kompleks yang berguna untuk mempengaruhi pikiran, perasaan dan tindakan konsumen demi kepentingan pengiklan, iklan merupakan bentuk komunikasi yang memiliki pesan yang kompleks karena memiliki tanda-tanda didalam iklan tersebut, tanda bisa jadi apa saja yang berada dalam iklan tersebut. Aqua merupakan perusahaan air minum dalam kemasan yang terbesar selama 5 tahun terakhir, dan membuat sebuah iklan baru yang membuat fokus konsumen yang baru yaitu anak-anak, dikarenakan terjadinya pandemi COVID-19. Hal ini menjadi menarik untuk diteliti karena air minum merupakan produk yang dapat dikonsumsi oleh segala jenis usia, namun Aqua memutuskan untuk membuat segmen baru dalam produknya, oleh karena itu iklan barunya pasti memiliki banyak tanda yang ingin disampaikan kepada calon konsumen, dengan demikian membutuhkan teknik semiotika. Semiotika merupakan studi yang mempelajari tentang tanda dan apapuyn yang berhubungan dengan tanda. Penelitian ini merupakan penelitian kualitatif dengan metode analisis semiotika Roland Barthes, pengumpulan data dengan cara observasi dan mengamati iklan Aqua Kids. Peneliti mengambil scene-scene dalam iklan tersebut dan mengidentifikasi tanda dan pesan dalam setiap scene, dengan konotatif dan denotatif. Hasil penelitian menunjukan, anak sulit berkonsentrasi dalam kegiatan belajar secara online, namun ketika ada Aqua kids, masalah tersebut hilang, dan membuat ibu senang dengan presetasi anak.
Расширение компетенций российского морского регистра судоходства. Введение требований к инновационным материалам и технологиям
Authors:   ФАУ «Российский морской регистр судоходства», Санкт-Петербург, Россия, Кордонец C.М. , Кутейников М.А. ,   ФАУ «Российский морской регистр судоходства», Санкт-Петербург, Россия, Кучапов А.В. ,   ФАУ «Российский морской регистр судоходства», Санкт-Петербург, Россия, Юрков М.Е. ,   ФАУ «Российский морской регистр судоходства», Санкт-Петербург, Россия
Published: March 2022

В статье рассматриваются инновационные материалы и технологии для судостроения и внедрение их в нормативную базу Российского морского регистра судоходства (далее-Регистр, РС) в 2020-2021гг. К таким технологиям относятся: сварка трением с перемешиванием, аддитивные технологии, полимерные композиционные материалы. При этом с практическим применением аддитивных технологий и сварки трением с перемешиванием Регистр сталкивается впервые. Опыт применения и нормирования технологий изготовления полимерных композиционные материалов в Регистре уже имелся, в данной статье рассматривается развитие применения данной технологии. В статье также, на примерах с указанными инновациями показан подход РС к их внедрению и совершенствованию Правил.
Could mean platelet volume be used as a marker for activity and severity index of alopecia areata?
Authors: Akpolat Nebahat Demet
Published: March 2022

Background. We aimed to determine whether MPV can be used as a marker for the activity and the severity index of alopesi areata (AA).
Method. The charts of 71 children who received a diagnosis of AA and 70 age and gender-matched healthy children were retrospectively evaluated. The severity of hair loss was classified as S1 ( < 25%), S2 (25-49%), S3 (50-74%), S4 (75-95%), S4b (96-99%) (according to the percent of the area involved), alopecia totalis (AT), and alopecia universalis (AU). In the laboratory tests, the results of the complete blood count, anti-nuclear antibody (ANA), thyroid function tests (TSH, free/total T4, free/total T3), and autoimmune thyroid antibodies [antithyroid peroxidase antibody (anti-TPO) and anti-thyroglobulin antibody (AT)] were recorded.
Results. A total of 141 cases including 61 (43.3%) males and 80 (56.7%) females were included. There was no statistically significant difference between the groups according to the mean age (p > 0.05). The MPV measurements were statistically significantly higher in the AA group (p < 0.01). There was no statistically significant difference between the types of AA according to the mean age, gender distribution, the presence of nail involvement, the presence of family history, and the presence of autoimmune disease (p > 0.05). There was no statistically significant difference between the severity of AA according to the mean age, gender distribution, the presence of nail involvement, the presence of family history, and the presence of autoimmune disease (p > 0.05).
Conclusion. MPV is helpful in assessing clinical activity in patients with AA. However, prospective studies involving more patients are needed to support our findings.
Saccharomyces cerevisiae fungemia due to an unexpected source in the pediatric intensive care unit
Authors: Gün Emrah , Özdemir Halil , Çelik Dilara Besli , Botan Edin , Kendirli Tanıl
Published: March 2022

Background. Saccharomyces cerevisiae is one of the microorganisms commonly used as a probiotic. Although it is primarily known as non-pathogenic, it may cause fungemia, particularly in immunocompromised patients or children with a history of long-term hospital stay.
Case. A 6-month-old boy with a history of ventriculostomy, ventriculoperitoneal shunt implantation, and external drainage due to an intracranial mass and hydrocephalus was admitted to the pediatric intensive care unit (PICU) on postoperative day 14 due to respiratory distress and intubated on admission. He was started on broad spectrum antibiotics on day 25 of the admission due to fever and clinical deterioration. Culture of the central venous catheter (CVC) yielded S. cerevisiae, the CVC was removed, and the patient was started on caspofungin. We noticed that a patient near this patient was on a probiotic preparation containing S. boulardii for diarrhea before PICU admission. His fever subsided on day 2 of caspofungin, and laboratory findings normalized on follow-up.
Conclusions. Probiotics should not be used in PICUs because of the high risk for CVC-related sepsis in critically ill children.
Clinicoepidemiological findings of childhood brucellosis in a tertiary care center in Central Anatolia: with the emphasis of hematological findings
Authors: Kaman Ayşe , Öz Fatma Nur , Fettah Ali , Durmuş Sevgi Yaşar , Teke Türkan Aydın , Tanır Gönül
Published: March 2022

Background. Human brucellosis is one of the most widespread zoonotic diseases that are presented with predominantly hematological manifestations. We aimed to evaluate the hematological findings of childhood brucellosis and to determine the predictive clinical findings and laboratory tests that might be related to hematologic involvement.
Methods. We retrospectively analyzed the medical records of children with brucellosis between 1 January 2005 and 31 December 2018. We compared predictive clinical and physical examination findings and laboratory tests in patients with and without hematological involvement.
Results. A total of 212 patients (127 boys (59.9%)) with a mean age of 9.4±4.7 years were evaluated in this study. Blood cultures were performed in 161 (75.9%) patients and Brucella spp were isolated in 70 (43.4%) of them. Ninety-two (43.4%) patients had hematological involvement at least in one series. Anemia was detected in 66 (31.7%) patients, leukopenia in 22 (10.6%) and thrombocytopenia in 10 (4.8%). Four patients (1.9%) had pancytopenia. Age distrubutions of the patients with and without hematological involvement were similar (p=0.6). In patients presented with fever, hepatomegaly and splenomegaly, hematologic involvement was significantly higher (p < 0.05). Hematological involvement was higher in patients who had elevated aspartate aminotransferase and alanine aminotransferase concentrations (p < 0.05). Hematological involvement was higher in patients with positive blood culture (p=0.005). Six patients (2.8%) were treated with intravenous immunoglobulin at 1000 mg/kg/day for two days in addition to anti-brucellosis treatment.
Conclusions. Hematological involvement in brucellosis is a common finding regardless of age, especially in febrile, bacteremic patients and in patients who had hepatosplenomegaly and elevated liver enzymes. Anemia is the most common hematological abnormality.
Trend in initial presenting features of type 1 diabetes mellitus over a 24 year period in Turkey: a retrospective analysis of 814 cases
Authors: Dündar İsmail , Akıncı Ayşehan , Camtosun Emine , Çiftçi Nurdan , Kayas Leman , Nalbantoğlu Özlem
Published: March 2022

Background. The study aim was to examine changes in trends of presenting features during the diagnosis of patients followed up with newly diagnosed Type 1 diabetes mellitus (T1DM) over the past 24 years.
Methods. The study was retrospective. Patients with a diagnosis of T1D between the years of 1996-2019 were included. Patients diagnosed in the first half of the period comprised Period I, and those from the second half comprised Period II. Patient data were extracted from medical records and included gender distribution, year of diagnosis, age at diagnosis, duration of symptoms, type of admission, frequency of diabetic ketoacidosis (DKA) and biochemical parameters. Subsequently, temporal changes in trends of these parameters were sought.
Results. For the whole cohort the gender distribution was equal; 404 (49.6%) were girls and 410 (50.4%) were boys. Mean age at diagnosis was 8.5±4.2 years and age groupings at presentation were: 23.2% (n = 189) aged 0-4; 39.2% (n = 319) aged 5-9; 27.5% (n = 224) aged 10-13; 10.1% (n= 82) aged 14-18. At presentation 72 (12.7%) had hyperglycemia, 230 (40.6%) had diabetic ketosis, and 264 (46.6%) had DKA. In those with DKA, mild DKA was found in 103 (39.0%), moderate DKA in 81 (30.6%), and severe DKA in 80 (30.3%). While the frequency of DKA was 54.9% between 1996 and 2007 (Period I), this significantly decreased to 44.4% between 2008 and 2019 (Period II). Girls and boys had a similar rate of T1DM, and this did not change over time. Three peak ages of diagnosis were evident; 5-7, 8-10, 12-14 years of age.
Conclusions. The frequency of DKA decreased and the frequency of admission with hyperglycemia and ketosis increased during the study period, which may have repercussions for mortality and morbidity rates and aid in improved treatment outcomes.
Clinical and molecular findings in 6 Turkish cases with Krabbe disease
Authors: Aslanger Ayça Dilruba , Şengenç Esma , Kölemen Ayşe Betül , Demiral Emine , Alkan Alpay , İşcan Akın , Yeşil Gözde
Published: March 2022

Background. Krabbe disease is a rare lysosomal storage disorder with a neurodegenerative course that occurs because of the deficiency of the beta-galactocerebrosidase (GALC) enzyme activity. The genetic basis of Krabbe disease consists of biallelic mutations in the GALC gene, but the genetic spectrum in the Turkish population is poorly defined. We aimed to present a Turkish case-series with infantile-onset Krabbe disease, define the clinical and molecular findings and compare the genetic spectrum with the mutations previously reported in the literature.
Methods. Six cases, who were referred to our clinic between 2015-2019, with a definite diagnosis of infantileonset Krabbe disease were included in the study. The family history, clinical information, biochemical and radiological examinations of the patients were screened and evaluated. All encoded exons and exon-intron regions of the GALC gene were sequenced using next generation sequencing technology. Multiplex ligationdependent probe amplification analysis was used for deletion type mutations that could not be detected by sequence analysis.
Results. GALC gene sequence analysis revealed four known mutations including c.1394C > T (p.Thr465Ile), c.411_413delTAA (p.Lys139del), c.820G > C (p.Glu274Gln), and 30 kilobase deletion mutation among the exons 11-17 (IVS10del30kbp). Moreover, the c.1623G > A (p.Trp541Ter) variant, which was not previously reported in the literature, was detected in two cases.
Conclusions. We believe that the demonstration of the genetic spectrum of infantile-onset Krabbe disease in Turkish patients will be an important contribution to the GALC mutation data in our country. More importantly, two novel variants were defined. This knowledge may enable early detection and treatment with the advent of a carrier or newborn screening tests.
Promoting adolescent health: health literacy, self-efficacy and internet use
Authors: Ceylan Dilara , Akan-Çelen Feyza Nur , Özkan Seçil , Aycan Zehra
Published: March 2022

Background. Adolescents are mostly considered as a healthy population; however, failure to acquire positive health behaviors during this period makes them vulnerable to poor health outcomes and long-term chronic disorders. Health literacy is one of the most influential parameters in promoting adolescent health. This study aimed to determine the level and promoters of health literacy in adolescents, emphasize the importance of internet use, and evaluate the relationship between self-efficacy and health literacy.
Methods. A total of 756 adolescents aged 15 and 18 years attending two high schools in socioeconomically different districts in Ankara, Turkey were included in this cross-sectional study. A survey consisting of descriptive questions, a health literacy survey, and a general self-efficacy scale were used to collect data. p < 0.05 was considered statistically significant.
Results. Among the adolescents who participated in the study, the level of health literacy was inadequatelimited in 56.1%, sufficient in 30.1%, and excellent in 13.8%. A statistically significant correlation was found between health literacy and general self-efficacy levels (r: .412, p < 0.001). There was also a statistically significant difference between the health literacy groups in terms of the education level of the adolescents` mothers, internet use frequency, and self-efficacy level. The multivariate logistic regression analysis revealed that the participants whose mothers had only received primary school education or no formal education, those that were not using the internet regularly, those that did not search health information on the internet, and those with poor self-efficacy levels were more likely to have an inadequate level of health literacy [odds ratio (OR)=2.6, 95% confidence interval (CI)=1.4-4.9; OR=5.5, 95% CI=1.2-25.1; OR=1.7, 95% CI=1.1-2.9; and OR=3.7, 95% CI=2.6- 5.2, respectively].
Conclusions. In this study, it was concluded that the adolescents` health literacy and general self-efficacy levels were related. Furthermore, the health literacy level of the adolescents was associated with internet use and maternal education status.
The potentially harmful excipients in prescribed medications in a Neonatal Intensive Care Unit in Kosovo and available safer alternatives
Authors: Koshi Blerina , Grapci Arlinda Daka , Nebija Dashnor , Selmani Pranvera Breznica , Morina Rina , Crcarevska Maja Simonoska , Dodov Marija Glavas , Raichki Renata Slaveska
Published: March 2022

Background. Medicinal products contain excipients that might be associated with toxicity in neonates. The aim of this study was to investigate the administration of medication containing potentially harmful excipients to neonates hospitalized in Kosovo and to identify the possibility of reducing neonatal exposure to these excipients through product substitution.
Methods. Data on all medication administered to hospitalized neonates from 1st of February to 1st of August 2018 along with patients` demographic data were collected from medical records for each neonate. Excipients were identified from the Summaries of Product Characteristics. Three stage criteria for product substitution were: (1) same active pharmaceutical ingredient (API) and route of administration; (2) 1 plus same dosage form; (3) 1 and 2 plus same strength.
Results. In total, 100 excipients were found in 2388 prescriptions comprising 67 medications and 60 API administered to 294 (183 preterm and 111 term) hospitalized neonates. The excipients of interest (EOI) were present in 409 (17.1%) prescriptions and were administered to 131 (71.6%) preterm and 52 (46.8%) term neonates through a relatively small number of products (n=27; 32.8%). In relation to prescription frequency, the most common EOI was polysorbate 80, found in 229 (56%) of EOI-containing prescriptions. Substitution with EOIfree products was possible for 14 (63.6%), 12 (54.5%) and 5 (22.7%) products, according to the first-, second- and third-stage criteria, respectively.
Conclusions. We have provided the first detailed description of neonatal exposure to potentially harmful excipients among neonates admitted to a neonatal intensive care unit in Kosovo. Unnecessary exposure could be reduced by using EOI-free products available in the local medicine market. Collaborative initiative is required to build up the evidence on the use of EOI in neonates and raising awareness among health care professionals on use of products without EOI where possible.
In vitro and in vivo evaluation of genotoxicity, cytotoxicity, and protective effects of synthetic chalcones (E)-3-(4-chlorophenyl)-1-phenyl-2-propen-1-one (4-CL) and (E)-3-(3,4-dimethoxyphenyl)-1- phenyl-2-propen-1-one (DMF)
Authors:   Molecular Genetics and Cytogenetics Laboratory, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Nunes Eliane Blanco , Melo Priscila Zei ,   Radiobiology and Mutagenesis Laboratory, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Barbosa Jefté ,   Radiobiology and Mutagenesis Laboratory, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Veras Jefferson Hollanda ,   Radiobiology and Mutagenesis Laboratory, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás, Silva Carolina Ribeiro e ,   Department of Morphology, Biological Sciences Institute, Federal University of Goiás, Goiânia, Goiás
Published: March 2022

The chalcones (E)-3-(4-chlorophenyl)-1-phenyl-2-propen-1-one (4-CL) and (E)-3-(3,4-dimethoxyphenyl)-1-phenyl-2 -propen-1-one (DMF) are versatile and easily synthesized into low-cost compounds that have a wide spectrum of biological activities. In this study, the cytotoxic, genotoxic and modulatory activities of 4-CL and DMF were evaluated using the Ames test and the mouse micronucleus assay. The results of the Ames test revealed that both chalcones did not show mutagenic activity in Salmonella typhimurium strains TA98 and TA100, and demonstrated significant antimutagenicity (p< 0.05) when co-administered with sodium azide (SA) in strain TA100. In the micronucleus assay, both showed a significant increase in the frequency of micronucleated polychromatic erythrocytes (MNPCE) at 24 h and 48 h, revealing a genotoxic effect. In the co-treatment with mitomycin C (MMC) there was a significant decrease (p< 0.05) in the frequency of MNPCE both in chalcones at 24h and in the less concentrated dose of DMF at 48h, demonstrating its antigenotoxic activity. 4-CL showed a significant decrease in the polychromatic/ normochromatic erythrocyte (PCE/ NCE) ratio at 24 and 48 h (p< 0.05), indicating cytotoxicity. However, 4-CL and DMF when co-administered with MMC showed a significant increase in the PCE/NCE ratio within 24 hours, demonstrating anticytotoxicity. Furthermore, a biphasic dose-response behavior was observed in both chalcones, 4-CL in the co-administration with SA, in the Ames Test and DMF in the co-treatment with MMC, at 48 hours of exposure, in the micronucleus assay. In this study, 4-CL and DMF showed genotoxic, cytotoxic, antigenotoxic, anticytotoxic and no mutagenic properties.
The rule of force: militarism and the militarization of politics in the early Brazilian Republic (1889-1890)
Authors: Ribeiro Filipe Nicoletti
Published: March 2022

This article addresses the immediate aftermath of the November 15, 1889, republican coup d’état in Brazil. Taken into account the diversity of the states’ political landscapes, its main theme is the profound transformation in the country’s political life precipitated by the abrupt passage from a parliamentary monarchy, marked by the ascendancy of civilian institutions, to a military dictatorship. it will be shown that, given the fact that republicans were a fragmented minority in most of the country, the military had preeminence in the implementation of the regime. However, considering that the coup was itself an act of insubordination, that control over institutions created frictions, and that the role of arbiters contaminated the barracks with the period’s extreme polarization, the liabilities of the militarization of politics were soon manifest. They were, most notably, the deep unrest and factionalism in the armed forces, the continuous institutional degradation, and the rise of authoritarianism.
“Apocalyptic” Ekphrasis (I. Bunin – A. Grin – B. Yulsky)
Authors: Kriukova M. I.
Published: March 2022

Purpose. The article is devoted to the story “Kaigorodov’s Line” by B. М. Yulsky, a writer of the Far Eastern emigration. The relevance of the work is determined by the increased interest in the work of Russian writers, who created their works outside of their homeland, but, nevertheless, reflected the traditions of Russian literature, as well as absorbed the culture of the environment. The purpose of the article is to consider the features of ekphrasis in Yulsky’s story “Kaigorodov’s Line”, to identify its functions.

Results. The methodological basis of the article is determined by the unity of the historical-literary, comparative and structural approaches. The article analyzes the intertextual typological echoes with I. Bunin and A. Grin’s stories. In the texts of the writers of the first half of the 20th century, the plot is centered on an artist who has come through the trials of life and who is craving to create a masterpiece. The ekphrasis in Yulsky’s story has a plot-forming function. It is noted that the text contains two ekphrasises: first, the artist draws a picture in his imagination, and the second one is his creation, as a reflection of the soul, tormented by his difficult fate.

Conclusion. It is concluded that the ekphrasis in Yulsky’s work is not only a separate description of the image in the text. The picture turns the course of events and defines the character’s fate. The ekphrasis in the story “Kaigorodov’s Line” is associated with the motive of madness and death.
The 8th International Scientific Conference “Peoples and Cultures of the SayanAltai and Bordering Territories”, Dedicated to the 300th Anniversary of the Discovery of Sites of the Yenisei Script and to the Year of Khakass Epic in the Republic of Khakassia
Authors: Khairullina N. G. , Troshkina I. N.
Published: March 2022

In the period from September 23 to 25 in Abakan (the Republic of Khakassia), the 8th International Scientific Conference “Peoples and Cultures of the Sayan-Altai and Bordering Territories”, dedicated to the 300th anniversary of the discovery of sites of the Yenisei script and to the Year of Khakass epic in the Republic of Khakassia was held. Significant objects of Old Turkic writing system and folklore heritage of this region are of particular interest to the scientific community. In this regard, it is important to highlight the results of the scientific event. The main purpose of the event was interaction, exchange of experience and results of scientific research in the field of humanities, preservation and study of monuments of writing and folklore. The conference was attended by more than 130 scientists from Mongolia, Japan, Uzbekistan, Turkey, Azerbaijan, Belarus, Finland, and Russia. The work was carried out in 5 sections, 1 round table devoted to relevant issues of archaeology of Southern Siberia and Central Asia. The conference showed the great importance of ethnic culture, which occupies one of the leading places in the study of historical and cultural heritage of a particular people, its role in the world community.
Development of calendar and planning production indicators based on the model of equipment life cycle
Authors:   Saint-Petersburg State University of Industrial Technologies and Design, Sirotina L. K.
Published: March 2022

The article is devoted to the problem of substantiation and regulation of calendar and planned production indicators. Estimation of the equipment life cycle cost at the stage of investment in its acquisition and commissioning will make it possible to make decisions on the usefulness period, on the indicators of production capacity and the level achieved, on the permissible values of equipment downtime, the expediency of working on its maintenance and other indicators related to the use of production equipment.
PLASTIC BARRIER DEFORMATION MECHANISM
Authors:   Tula State University, Tula, Russia, Proskuriakov N. E. , Lopa I. V. ,   Tula State University, Tula, Russia
Published: March 2022

Рассматривается ударное нагружение преграды из пластичного материала. Постулируется, что процесс деформирования можно моделировать двумя самостоятельными сопряженными задачами: деформация преграды как плиты конечной толщины из упруго-вязкопластического материала жестким ударником и оценка потери энергии ударника на деформирование материала под ним и преодоление силы лобового сопротивления. Показано, что, с одной стороны, наиболее существенны потери энергии ударника на деформирование материала преграды продольными волнами напряжений и на формирование, и на срез пробки, а с другой, процесс выдвижения сформировавшейся пробки наиболее длителен и формирует, в основном, время пробития.
CALCULATING OF DEFORMATION SPEED AT ELECTROMAGNETIC FORMING
Authors:   Tula State University, Tula, Russia, Proskuriakov N. E. , Lopa I. V. ,   Tula State University, Tula, Russia, Zverev I. V. ,   Imperial Tula Arms Factory, Tula, Russia
Published: March 2022

Рассматривается влияние скорости деформации, величины пластической деформации и температуры материала на характеристики материала при магнитно-импульсной штамповке. Показано, что прочностные характеристики возрастают с ростом скорости деформации, а пластичность увеличивается с ростом величин пластической деформации и температуры. Предложен вариант записи определяющего соотношения, учитывающего эти изменения, а его использование в расчетах может существенно повысить эффективность расчетов операций магнитно-импульсной штамповки.
MICROSTRUCTURE OF SPHERICAL GRANULES BASED ON HYDROXYAPATITE AND WOLLASTONITE
Authors:   Omsk State Medical University, Omsk, Russia, Solonenko A. P. , Chikanova E. S. ,   Omsk State Medical University, Omsk, Russia; Dostoevsky Omsk State University, Omsk, Russia, Shevchenko A. E. ,   Omsk State Medical University, Omsk, Russia; Omsk State Technical University, Omsk, Russia, Polonyankin D. A. ,   Omsk State Technical University, Omsk, Russia
Published: March 2022

Сферические гранулы являются одной из предпочтительных форм биоматериалов, предназначенных для терапии дефектов костных тканей. Химический состав и микроструктура данных препаратов в существенной степени определяет их поведение in vivo. Представляет интерес получениеи исследование полидисперсных пористых композитных гранулированных материалов, содержащих в своем составе несколько биоактивных компонентов. В данной работе изучена микроструктура органо-минеральных гранул на основе гидроксиапатита, волластонита и желатина, и продуктов их прокаливания. Установлено, что в результате удаления полимера-связки с поверхности частиц керамических порошков открываются нанопоры, а последующее спекание кристаллитов обеспечивает сохранность формы гранул.
The largest international digital logistics platforms: comparative analysis
Authors:   Peter the Great St. Petersburg Polytechnic University, Barykin S. E. , Egereva Yu. B. ,   SNT «Corvet na Kuple», Korchagina E. V. ,   Peter the Great St. Petersburg Polytechnic University, Kalinina O. V. ,   Peter the Great St. Petersburg Polytechnic University, Fedorova E. S. ,   Peter the Great St. Petersburg Polytechnic University
Published: March 2022

Taking these prospects into account, the integration potential of Russia in the conditions of gradual trade and economic unity of the ASEAN countries can be considered in the aspect of formation of new strategic opportunities for interaction with the integration environment of Eurasia on the basis of investments in infrastructure development within the framework of the Eurasian Economic Union (EAEU). The advantages and disadvantages of the digital platforms and the characteristic features of international DLPs are highlighted. Based on the analysis, the necessity of developing an international digital platform in the EAEU is justified in the context of the development of international digital logistics platforms within the framework of the Eurasian Economic Union.
Saúde reprodutiva feminina no Brasil durante a pandemia da Covid-19: fecundidade, contracepção e pré-natal: uma revisão narrativa
Authors: Oliveira Anna Clara de Jesus , Gonçalves Emanuelle Cristina Soares , Oliveira Gabriela Alves de , Marcolino Giulia de Jesus , Paulino Luanna Simão , Campos Fabrício Alves de Oliveira
Published: March 2022

Objetivo: Sintetizar evidências científicas sobre os impactos da pandemia da Covid-19 na saúde reprodutiva das mulheres brasileiras, dando enfoque na fecundidade, contracepção e pré-natal. Revisão bibliográfica: Nesse sentido, como efeitos diretos da pandemia na saúde reprodutiva da mulher, temos o aumento da mortalidade materna, o crescente número de gravidezes imprevistas, o maior número de abortos ilegais, o aumento da violência contra a mulher e a dificuldade de se fazer educação em saúde. Dessa forma, ainda evidenciou-se que as mulheres foram o grupo da população mais afetado pela pandemia na medida em que os serviços essenciais são majoritariamente exercidos por elas. Considerações finais: Nota-se a grande importância de abordagem do tema haja vista que houve uma grande dificuldade de encontrar artigos sobre o assunto e por que a saúde reprodutiva é um direito irrevogável, mas que se encontra pouco acessível em tempos de pandemia, haja vista as dificuldades de se fazer planejamento familiar.
Perancangan Tata Kelola Teknologi Informasi dengan Menggunakan Framework Cobit 2019 pada PT XYZ Balikpapan
Authors: Wulandari Endah , Atrinawati Lovinta Happy , Putra M. Gilvy Langgawan
Published: March 2022

PT XYZ Balikpapan menyediakan berbagai layanan, yaitu layanan  pengujian dan analisis, penilaian dan audit, pelatihan dan sertifikasi di berbagai bidang. Terkait pemanfaatan teknologi informasi yang tidak berjalan dengan baik, berdampak pada optimalisasi pelaksanaan tujuan bisnis dan berdampak pada ancaman terkait teknologi informasi. Akibatnya, manajemen menggunakan kerangka kerja COBIT 2019 untuk membantu bisnis mencapai tujuan yang diinginkan. Langkah-langkah merancang manajer teknologi informasi berdasarkan kerangka COBIT 2019 dengan wawancara untuk mempelajari lebih lanjut tentang perusahaan dan strateginya. Selanjutnya, tentukan ruang lingkup awal sistem administrasi. Meningkatkan cakupan administrasi sistem, menyempurnakan desain tata kelola, mengevaluasi kapabilitas proses, menyiapkan proposal perbaikan, dan mengembangkan temuan rekomendasi perbaikan. Nilai pada tingkat kapabilitas dilakukan yang memiliki nilai lebih besar dari sama dengan 75, tingkat target kapabilitas pada level 4. Ditemukan proses yang sangat penting pada PT XYZ Balikpapan memiliki tingkat kapabilitas di level 1 APO09 Managed Service Agreements, APO12 Managed Risk, APO13 Managed Security, dan DSS02 Managed Service Requests & Incidents. Semua proses yang mengevaluasi tingkat keterampilan gagal mencapai tingkat kapabilitas. Oleh karena itu, semua kegiatan selama proses dilakukan dan menghasilkan rekomendasi untuk perbaikan. Pertama yaiyu core model APO09 pada dokumen analisis kebutuhan kapasitas mendatang, service level agreement dan service catalog supaya mendapatkan meningkatkan output kinerja perusahaan dalam melayani pelanggan pada PT XYZ Balikpapan.

 

Kata kunci: COBIT 2019, PT XYZ Balikpapan, tata kelola teknologi informasi
Perancangan Keamanan Internet Jaringan Hotspot Mikrotik pada Winbox dan Wireshark
Authors: Dasmen Rahmat Novrianda , Syarif Abdur Rohman , Saputra Heru , Amrullah Rahmat
Published: March 2022

Mikrotik, a technology that provides Internet services by turning computers into network routers. The computer network of SMA Negeri 16 Palembang uses a traditional cable network with star type. In this research, the process of designing a network using Mikrotik and managing and distributing bandwidth as needed at SMA Negeri 16 Palembang is carried out using the Network Development Life Cycle (NDLC) model. The result of this research is that Mikrotik can manage all computer networks. In the distribution of bandwidth regularly on the proxy can provide efficiency over the use of the internet. Mikrotik can maximize network usage if the overall bandwidth has been set.

 

Keywords: Mikrotik, Computer Network, Router and Type Network
Experimental and Theoretical Investigation of Asymmetric Induction in the Synthesis of Disubstituted Cyclohexadienes via Chiral Benzene Chromium Complexes
Authors: Bernardinelli Gerald , Cunningham Allan , Dupré Chantal , Kündig E. Peter , Stussi Dominique , Weber Jacques
Published: March 2022

A series of [Cr(benzene)(CO)2L] complexes with L = PPh3, P(OMe)3, PPh2 ((–)-menthyl), P(OPh)2(O-(–)-menthyl), P(O-(–)-menthyl)3 were subjected to a nueleophile addition/acylation sequence to give trans-5,6-disubstituted cyelohexadienes. Low-to-moderate asymmetric induction was observed with the chiral ligands. Experimental and theoretical evidence for an alkylation at the metal center trans to the P ligand is presented, and a crystal structure determination of a [Cr(η5–cyclohexadienyl)(P(OMe)3)(CO)2SnPh3] complex is included.
Quantitative Capillary Supercritical Fluid Chromatography and Supercritical Fluid Extraction of Basic Drugs of Abuse
Authors: Edder Patrick , Haerdi Werner , Veuthey Jean-luc , Staub Christian
Published: March 2022

Capillary SFC of basic drugs of abuse have been studied using two different columns, and the results were compared with GC. These results have proved the ability of supercritical CO2 to solubilize and extract basic drugs of interest. A novel restrictor has been used to control precisely the flow rate through the extraction cell over a long period of time. Optimal conditions for quantitative recoveries of aqueous morphine adsorbated on C18 silica by SFE has been determined. Recoveries of 100% with a variation of 2% was obtained with an extraction time of 25 min. The influence of the pressure, solvent modifier, and flow rate of extraction fluid on the extraction efficiency was determined. These conditions were also found to be applicable for extracting other drugs of abuse.
The role of results-based strategic planning in financing small projects to increase production -A field study on financial institutions and owners of small projects-: دور التخطيط الاستراتيجي المبني على النتائج في تمويل المشاريع الصغيرة لزيادة الإنتاج – دراسة ميدانية على المؤسسات التمويلية وأصحاب المشاريع الصغيرة –
Authors: Huda Diyab Ahmed Salih, Randa Abd Elhamied Mohammed Hamza Huda Diyab Ahmed Salih, Randa Abd Elhamied Mohammed Hamza
Published: March 2022

The research aims to light on the results-based strategic planning for financing small projects and its role in increasing production and productivity from the perspectives of financial institutions and owners of small projects through studying the hypotheses that First hypothesis: There is a statistically significant relationship between results-based strategic planning in financing small projects and increasing production and productivity from the point of view of financing institutions in Sudan. Second hypothesis: There is a statistically significant relationship between results-based strategic planning in financing small projects and increasing production and productivity from the perspective of small business owners in Sudan. To study the hypotheses and achieve the objectives of the research, the inductive, deductive and historical approach was followed, and the questionnaire tool was used to collect data, and the analysis was done using the Statistical Packages Program (SPSS) to analyze the search hypotheses phrases using the frequency table and the arithmetic mean to show the differences in the answers of the research sample. From the financial institutions and owners of small projects, the research reached a set of results, including: The financing of small projects from the perspectives of financial institutions and owners of small projects is carried out according to strategic planning based on results in Sudan to ratio (%80). The research also recommended many recommendations, including: A lot of research and studies should be done in strategic planning based on results.
Saudi labor market requirements between reality and the challenges of higher education to achieve Vision 2030: Japan's experience as a model: متطلبات سوق العمل السعودي بين الواقع وتحديات التعليم العالي لتحقيق رؤية 2030 تجربة اليابان أنموذجاً
Authors: Hayat M. Alqarawi Hayat M. Alqarawi
Published: March 2022

The current study aimed to identify the requirements of the Saudi labor market and the reality and challenges of Saudi higher education to achieve the Kingdom's 2030 vision. This research relied on the documentary analytical method, by analyzing the reality of higher education, development plans, the Kingdom's vision 2030 and the extent to which education outputs are compatible with the labor market. To achieve the study's goal, the Japanese experience was used. This study relied on the documentary analytical method, by analyzing the reality of Saudi higher education, development plans, and the Kingdom’s vision 2030. The study included a number of documents: - Development plans for the Kingdom of Saudi Arabia - The future plan for university education in the Kingdom of Saudi Arabia: Afaq project - The Kingdom's Vision 2030 - A number of Saudi and Japanese researches and studies A comparison was made between the experiences of Saudi Arabia and Japan to align the outputs of education with the labor market, recommendations were presented to match the outputs of higher education with the actual needs of the Saudi labor market.
The implications of Qassem Soleimani assassination on US- Iranian relations: تداعيات اغتيال قاسم سليماني على العلاقات الأمريكية الإيرانية
Authors: Noura Ali Abdallah Noura Ali Abdallah
Published: March 2022

This study deals with the repercussions of the assassination of Iranian military commander Qassem Soleimani on US- Iranian relations, and the US- Iranian escalation and tension in Iraq and the entire surrounding region. The study tries to determine the indicators of the US- Iranian escalation and the effect of the bombing incident near Baghdad Airport on January 4, 2020, at the interior of Iranian, and at the regional and international level. It seeks to estimate the potential for escalation between the United States of America and Iran; the latter surprised the group of 4 + 1 countries on the anniversary of Soleimani assassination in 2021 by increasing the rate of uranium enrichment to 20%. This step will be taken in consideration in any future negotiations between Iran and the United States of America and the European Union if US President Joe Biden decides to return to the nuclear accord. The results of the study concluded that the previous US approach in the Trump administration affected negatively on any future negotiation about the return of US to the Joint Comprehensive Plan of Action. US President Joe Biden is trying to mitigate his predecessor’s escalation of US- Iranian relations; nonetheless, Israel seeks to obstruct any path that would end the tension between Washington and Tehran.
The Association between Neuroticism and Re-Attempted Suicide
Authors:   Department of Clinical Sciences, Lund, Psychiatry, Lund University, Clinical Psychiatric Research Center, Region Skåne, Sweden, S Probert-Lindström , L Ambrus ,   Department of Clinical Sciences, Lund, Psychiatry, Lund University, Clinical Psychiatric Research Center, Region Skåne, Sweden
Published: March 2022

Background: Strong evidence suggests that suicide attempters who repeat suicide (re-attempters) may differ from those with a single attempt (single attempters) in various clinical and sociodemographic factors. Furthermore, there is some evidence that re-attempters may be characterized by higher levels of neuroticism, a well-known risk factor for completed suicide compared to single attempters. Purpose: The aim of the present study was to investigate the possible association between neuroticism and re-attempted suicide. Methods and Materials: 230 recent drug-free suicide attempters were involved into the study. Clinical diagnoses were assessed by the Diagnostic and Statistical Manual of Mental Disorders, Third Edition-Revised (DSM-III-R). Personality traits were measured by the Karolinska Scale of Personality (KSP). Results and Conclusions: There was a significant association between re-attempted suicide, female gender, personality disorder and higher levels of impulsivity. We found that re-attempters had significantly higher levels of neuroticism compared to single attempters adjusted of gender, personality disorder diagnosis, age and impulsivity. Our result gives further evidence for the association between re-attempted suicide and neuroticism.
The Ratios of Total Serum Protein to Protein Electrophoretic Fractions during Pregnancy as Diagnostic Information
Authors:   Department of Biochemistry and Clinical Chemistry, Medical University of Warsaw, Poland, B Lisowska-Myjak , E Skarżyńska ,   Department of Biochemistry and Clinical Chemistry, Medical University of Warsaw, Poland, H Zborowska ,   Department of Laboratory Diagnostics, Medical University of Warsaw, Poland, A Strawa ,   Department of Biochemistry and Clinical Chemistry, Medical University of Warsaw, Poland, A Jakimiuk ,   Department of Reproductive Health, Institute of Mother and Child and Department of Obstetrics and Gynecology, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland
Published: March 2022

Background: Ratios of total serum protein (TP) concentrations to serum protein electrophoretic fractions could reflect impact on intravascular homeostasis in pregnancy of qualitative and quantitative changes in highabundance protein of serum between consecutive trimesters. Methods: TP concentrations were measured by biuret method and six protein fractions were separated by electrophoresis in 186 serum samples from 65 healthy pregnant women in each trimester of normal singleton pregnancy and from 20 non-pregnant women. Results: TP/fraction ratios in pregnancy and postpartum period differed from those in non-pregnancy. Ratios of TP/ protein fractions changed across trimesters, mostly between first and second trimesters with increase in TP / albumin ratio by 5% while ratios TP/alpha-1-, TP/alpha-2- and TP/beta-1- globulin decreased by 22%, 15% and 15%, respectively. TP/gamma-globulin ratio increased by 15% between second and third trimesters. Conclusions: Ratios of TP concentrations to specific protein fractions may reflect trimester-specific qualitative and quantitative changes in serum content of high-abundance proteins and their effect on serum protein homeostasis in pregnancy. Decreased ratios of TP to alpha-1-, alpha-2-, beta-1- and beta-2- globulins confirm increases in concentrations of individual proteins contained in these fractions with development of pregnancy, with largest increase in level of alpha-1-globulin in earliest period of pregnancy
About the Phenomenon of Iatrogenic Endocrine Disruption in the Female Pig’s Reproductive Endocrine System
Authors:   Sztaravodai u. 40, H-2000 Szentendre, Hungary, L Makay
Published: March 2022

Endocrine disruptors have been present in our environment since the tide of stable, man-made chemicals of the Industrial Age arose. As it has turned out, one of the medicaments used in my studies, diethylstilboestrol (DES), is also a very potent endocrine disruptor. These field trials took place a long time ago, in the 1960s, when the use of this kind of treatment was still authorized in the veterinary medical practice in order to hormonally castrate fattening female pigs instead of the traditional surgical intervention. Diethylstilboestrol (DES) was then suggested to be administered to pigs for this purpose. However, now DES must not be administered to food animals at all. The result of the hormonal treatment of pigs was then believed to be a consequence of a negative feedback reaction. Nevertheless, thorough investigations found that the induced reaction was not a negative, but on the contrary, a positive feedback reaction. In the meantime it came to light that the medicament DES itself is a most potent endocrine disruptor. Later it became clear that this positive feedback reaction could be regarded as the manifestation of the significant protective effect of the corpus luteum function, the organism’s own, natural shield aimed at preventing certain disrupting factors. This seems to be a promising domain worthy of doing research on.
Electrochemical Oxidative Rearrangement of Tetrahydro-β-carbolines in Zero-gap Flow Cell
Authors: Zheng Yiting , Chueng Yuen Tsz , Liang Lixin , Qiu Huiying , Tong Terry , Zhang Lei , Tsang Anson , Chen Qing , Tong Rongbiao
Published: March 2022

Oxidative rearrangement of tetrahydro-β-carbolines (THβCs) is one of the most widely used reactions for the synthesis of biologically active spirooxindoles (natural products and drug molecules). While enzymatic and chemical oxidation methods have been well established for this transformation, the corresponding electrochemical approach remain unknown. Herein, we reported the first electrochemical oxidative rearrangement of THβCs in a zero-gap flow cell. Under the optimal condition, the reaction can afford the desired spirooxindoles with up to 97% yield at a Faradaic efficiency (FE) of 96% and a productivity of 0.144 mmol/(h*cm2), which is the best among similar organic electrochemical reactions. Additionally, we discovered lithium ion played a key role in improving the reaction yield.
Scaffold Generator - A Java library implementing molecular scaffold functionalities in the Chemistry Development Kit (CDK)
Authors: Schaub Jonas , Zander Julian , Zielesny Achim , Steinbeck Christoph
Published: March 2022

The concept of molecular scaffolds as defining core structures of organic molecules is utilised in many areas of chemistry and cheminformatics, e.g. drug design, chemical classification, or the analysis of high-throughput screening data. Here, we present Scaffold Generator, a comprehensive open library for the generation, handling, and display of molecular scaffolds, scaffold trees and networks. The new library is based on the Chemistry Development Kit (CDK) and highly customisable through multiple settings, e.g. five different structural framework definitions are available. For display of scaffold hierarchies, the open GraphStream Java library is utilised. Performance snapshots with natural products (NP) from the COCONUT database and drug molecules from DrugBank are reported. The generation of a scaffold network from more than 450,000 NP can be achieved within a single day.