Acid-base condition of blood in patients with urolithiasis. Study II. Role of blood pH.
Authors:   Department of Urolithiasis of N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Centre of Radiology of Ministry of health of Russian Federation, N.V. Anokhin ,   Moscow, Russia, M.Yu. Prosyannikov ,   he Department of Urolithiasis of N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Centre of Radiology of Ministry of health of Russian Federation; Moscow, Russia, O.V. Konstantinova ,   the Department of Urolithiasis of N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Centre of Radiology of Ministry of health of Russian Federation; Moscow, Russia, S.A. Golovanov ,   the clinical laboratory diagnostics group of the scientific and laboratory department of N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Centre of Radiology of Ministry of health of Russian Federation; Moscow, Russia, D.A. Voуtko ,   Department of Urolithiasis of N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Centre of Radiology of Ministry of health of Russian Federation; Moscow, Russia, A.V. Sivkov ,   Scientific Work of N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Centre of Radiology of Ministry of health of Russian Federation; Moscow, Russia, O.I. Apolikhin ,   RAS, N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Centre of Radiology of Ministry of health of Russian Federation; Moscow, Russia, A.D. Kaprin ,   RAS, general director of the National Medical Research Centre of Radiology of Ministry of health of Russian Federation, director of P.A. Herzen Institution, Head of Department of Oncology and Radiology named after V.P. Kharchenko of RUDN University; Moscow, Russia
Published: May 2024

Introduction. We will try to show the place of acid-base balance (ABB) study in urolithiasis patients. There is the second article in a series of works devoted to the study of ABB in urolithiasis patients. This work is devoted to the study of the level of basic acid base indicators: blood pH, pCO2, pO2, BE. Materials and methods. The study was conducted prospectively at the N. Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiological Center of the Ministry of Health of the Russian Federation. We analyzed data of 83 urolithiasis patients (39 men and 44 women). All patients underwent an analysis of the urinary stones chemical composition, biochemical analysis of blood and daily urine, blood acid-basic balance, blood parathyroid hormone. Urine pH morning was determined for all patients. Results. Patients with acidemia (blood pH <7.32) had significantly higher concentrations of chlorine, creatinine and ionized calcium in the blood than in the group of patients with 7.32 <blood pH <7.42. The BE indicator is significantly lower than in the comparison group. There is a higher level of total blood calcium (p<0.05) and magnesium excretion, a lower level of serum concentration of creatinine (p<0.05), urea (p<0.05) and chlorine (p<0.05) in the group of patients with hypercapnia (pCO2 >51 mmHg) than in patients with 41< pCO2 <51 mmHg. Patients with a BE level <-2.5 had significantly higher levels of creatinine, urea and chlorine in the blood, and higher urine pH (p<0.05) compared to patients with BE>2.5. Patients with BE < -2.5 also had significantly lower level of blood pH, pCO2 and ionized calcium compared to the group of patients with BE >2.5. Conclusion. Normalization of blood pH is capable to correct the metabolism of the main lithogenic substances in urolithiasis patients.