bluuebunny/crossref_metadata_2025 huggingface dataset:
Daylight Design of Office Buildings: Optimisation of External Solar Shadings by Using Combined Simulation Methods
Authors: González Javier , Fiorito Francesco
Published: May 2015

Integrating daylight and energy performance with optimization into the design process has always been a challenge for designers. Most of the building environmental performance simulation tools require a considerable amount of time and iterations for achieving accurate results. Moreover the combination of daylight and energy performances has always been an issue, as different software packages are needed to perform detailed calculations. A simplified method to overcome both issues using recent advances in software integration is explored here. As a case study; the optimization of external shadings in a typical office space in Australia is presented. Results are compared against common solutions adopted as industry standard practices. Visual comfort and energy efficiency are analysed in an integrated approach. The DIVA (Design, Iterate, Validate and Adapt) plug-in for Rhinoceros/Grasshopper software is used as the main tool, given its ability to effectively calculate daylight metrics (using the Radiance/Daysim engine) and energy consumption (using the EnergyPlus engine). The optimization process is carried out parametrically controlling the shadings’ geometries. Genetic Algorithms (GA) embedded in the evolutionary solver Galapagos are adopted in order to achieve close to optimum results by controlling iteration parameters. The optimized result, in comparison with conventional design techniques, reveals significant enhancement of comfort levels and energy efficiency. Benefits and drawbacks of the proposed strategy are then discussed.
Sagnac Effect, Ring Lasers and Terrestrial Tests of Gravity
Authors: Ruggiero Matteo
Published: May 2015

Light can be used as a probe to explore the structure of space-time: this is usual in astrophysical and cosmological tests; however, it has been recently suggested that this can be done also in terrestrial laboratories. Namely, the Gyroscopes In General Relativity (GINGER) project aims at measuring post-Newtonian effects, such as the gravito-magnetic ones, in an Earth-based laboratory, by means of a ring laser array. Here, we first review the theoretical foundations of the Sagnac effect, on which ring lasers are based, and then, we study the Sagnac effect in a terrestrial laboratory, emphasizing the origin of the gravitational contributions that GINGER aims at measuring. Moreover, we show that accurate measurements allow one to set constraints on theories of gravity different from general relativity. Eventually, we describe the experimental setup of GINGER.
Gateway Effects: Why the Cited Evidence Does Not Support Their Existence for Low-Risk Tobacco Products (and What Evidence Would)
Authors: Phillips Carl
Published: May 2015

It is often claimed that low-risk drugs still create harm because of “gateway effects”, in which they cause the use of a high-risk alternative. Such claims are popular among opponents of tobacco harm reduction, claiming that low-risk tobacco products (e.g., e-cigarettes, smokeless tobacco) cause people to start smoking, sometimes backed by empirical studies that ostensibly support the claim. However, these studies consistently ignore the obvious alternative causal pathways, particularly that observed associations might represent causation in the opposite direction (smoking causes people to seek low-risk alternatives) or confounding (the same individual characteristics increase the chance of using any tobacco product). Due to these complications, any useful analysis must deal with simultaneity and confounding by common cause. In practice, existing analyses seem almost as if they were designed to provide teaching examples about drawing simplistic and unsupported causal conclusions from observed associations. The present analysis examines what evidence and research strategies would be needed to empirically detect such a gateway effect, if there were one, explaining key methodological concepts including causation and confounding, examining the logic of the claim, identifying potentially useful data, and debunking common fallacies on both sides of the argument, as well as presenting an extended example of proper empirical testing. The analysis demonstrates that none of the empirical studies to date that are purported to show a gateway effect from tobacco harm reduction products actually does so. The observations and approaches can be generalized to other cases where observed association of individual characteristics in cross-sectional data could result from any of several causal relationships.
Introducing Simple Detection of Bioavailable Arsenic at Rafaela (Santa Fe Province, Argentina) Using the ARSOlux Biosensor
Authors: Siegfried Konrad , Hahn-Tomer Sonja , Koelsch Andreas , Osterwalder Eva , Mattusch Juergen , Staerk Hans-Joachim , Meichtry Jorge , De Seta Graciela , Reina Fernando , Panigatti Cecilia , Litter Marta , Harms Hauke
Published: May 2015

Numerous articles have reported the occurrence of arsenic in drinking water in Argentina, and the resulting health effects in severely affected regions of the country. Arsenic in drinking water in Argentina is largely naturally occurring due to elevated background content of the metalloid in volcanic sediments, although, in some regions, mining can contribute. While the origin of arsenic release has been discussed extensively, the problem of drinking water contamination has not yet been solved. One key step in progress towards mitigation of problems related with the consumption of As-containing water is the availability of simple detection tools. A chemical test kit and the ARSOlux biosensor were evaluated as simple analytical tools for field measurements of arsenic in the groundwater of Rafaela (Santa Fe, Argentina), and the results were compared with ICP-MS and HPLC-ICP-MS measurements. A survey of the groundwater chemistry was performed to evaluate possible interferences with the field tests. The results showed that the ARSOlux biosensor performed better than the chemical field test, that the predominant species of arsenic in the study area was arsenate and that arsenic concentration in the studied samples had a positive correlation with fluoride and vanadium, and a negative one with calcium and iron.
Optimization of NaOH Molarity, LUSI Mud/Alkaline Activator, and Na2SiO3/NaOH Ratio to Produce Lightweight Aggregate-Based Geopolymer
Authors: Razak Rafiza , Abdullah Mohd , Hussin Kamarudin , Ismail Khairul , Hardjito Djwantoro , Yahya Zarina
Published: May 2015

This paper presents the mechanical function and characterization of an artificial lightweight geopolymer aggregate (ALGA) using LUSI (Sidoarjo mud) and alkaline activator as source materials. LUSI stands for LU-Lumpur and SI-Sidoarjo, meaning mud from Sidoarjo which erupted near the Banjarpanji-1 exploration well in Sidoarjo, East Java, Indonesia on 27 May 2006. The effect of NaOH molarity, LUSI mud/Alkaline activator (LM/AA) ratio, and Na2SiO3/NaOH ratio to the ALGA are investigated at a sintering temperature of 950 °C. The results show that the optimum NaOH molarity found in this study is 12 M due to the highest strength (lowest AIV value) of 15.79% with lower water absorption and specific gravity. The optimum LUSI mud/Alkaline activator (LM/AA) ratio of 1.7 and the Na2SiO3/NaOH ratio of 0.4 gives the highest strength with AIV value of 15.42% with specific gravity of 1.10 g/cm3 and water absorption of 4.7%. The major synthesized crystalline phases were identified as sodalite, quartz and albite. Scanning Electron Microscope (SEM) image showed more complete geopolymer matrix which contributes to highest strength of ALGA produced.
Genetic Variant rs10757278 on Chromosome 9p21 Contributes to Myocardial Infarction Susceptibility
Authors: Chen Guangyuan , Fu Xiuhua , Wang Guangyu , Liu Guiyou , Bai Xiuping
Published: May 2015

Large-scale genome-wide association studies (GWAS) have revealed that rs10757278 polymorphism (or its proxy rs1333049) on chromosome 9p21 is associated with myocardial infarction (MI) susceptibility in individuals of Caucasian ancestry. Following studies in other populations investigated this association. However, some of these studies reported weak or no significant association. Here, we reevaluated this association using large-scale samples by searching PubMed and Google Scholar databases. Our results showed significant association between rs10757278 polymorphism and MI with p = 6.09 × 10−22, odds ratio (OR) = 1.29, 95% confidence interval (CI) 1.22–1.36 in pooled population. We further performed a subgroup analysis, and found significant association between rs10757278 polymorphism and MI in Asian and Caucasian populations. We identified that the association between rs10757278 polymorphism and MI did not vary substantially by excluding any one study. However, the heterogeneity among the selected studies varies substantially by excluding the study from the Pakistan population. We found even more significant association between rs10757278 polymorphism and MI in pooled population, p = 3.55 × 10−53, after excluding the study from the Pakistan population. In summary, previous studies reported weak or no significant association between rs10757278 polymorphism and MI. Interestingly, our analysis suggests that rs10757278 polymorphism is significantly associated with MI susceptibility by analyzing large-scale samples.
Oxidized LDL Is Strictly Limited to Hyperthyroidism Irrespective of Fat Feeding in Female Sprague Dawley Rats
Authors: Zelzer Sieglinde , Mangge Harald , Pailer Sabine , Ainoedhofer Herwig , Kieslinger Petra , Stojakovic Tatjana , Scharnagl Hubert , Prüller Florian , Weghuber Daniel , Datz Christian , Haybaeck Johannes , Obermayer-Pietsch Barbara , Trummer Christian , Gostner Johanna , Gruber Hans-Jürgen
Published: May 2015

Metabolic dysfunctions might play a crucial role in the pathophysiology of thyroid dysfunctions. This study aimed to investigate the impact of a controlled diet (normal versus high fat feeding) on hypothyroid and hyperthyroid Sprague Dawley rats. Female Sprague Dawley rats (n = 66) were grouped into normal diet (n = 30) and high-fat diet (n = 36) groups and subdivided into controls, hypothyroid and hyperthyroid groups, induced through propylthiouracil or triiodothyronine (T3) treatment, respectively. After 12 weeks of treatment metabolic parameters, such as oxidized LDL (oxLDL), malondialdehyde (MDA), 4-hydroxynonenal (HNE), the lipid profile, body weight and food intake parameters were analyzed. Successfully induced thyroid dysfunctions were shown by T3 levels, both under normal and high fat diet. Thyroid dysfunctions were accompanied by changes in calorie intake and body weight as well as in the lipid profile. In detail, hypothyroid rats showed significantly decreased oxLDL levels, whereas hyperthyroid rats showed significantly increased oxLDL levels. These effects were seen under high fat diet and were less pronounced with normal feeding. Taken together, we showed for the first time in female SD rats that only hyper-, but not hypothyroidism, is associated with high atherogenic oxidized LDL irrespective of normal or high-fat diet in Sprague Dawley rats.
MicroRNA-24 Regulates Osteogenic Differentiation via Targeting T-Cell Factor-1
Authors: Zhao Weigong , Wu Caijun , Dong Yanying , Ma Yunfeng , Jin Yaofeng , Ji Yanhong
Published: May 2015

MicroRNAs (miRNAs) have been reported to have diverse biological roles in regulating many biological processes, including osteogenic differentiation. In the present study, we identified that miR-24 was a critical regulator during osteogenic differentiation. We found that overexpression of miR-24 significantly inhibited osteogenic differentiation, which decreased alkaline phosphatase activity, matrix mineralization and the expression of osteogenic differentiation markers. In contrast, inhibition of miR-24 exhibited an opposite effect. Furthermore, we delineated that miR-24 regulates post-transcriptionals of T-cell factor-1 (Tcf-1) via targeting the 3'-untranslated region (UTR) of Tcf-1 mRNA. MiR-24 was further found to regulate the protein expression of Tcf-1 in the murine osteoprogenitors cells and bone mesenchymal stem cells. Additionally, the positive effect of miR-24 suppression on osteoblast differentiation was apparently abrogated by Tcf-1 silencing. Taken together, our data suggest that miR-24 participates in osteogenic differentiation by targeting and regulating Tcf-1 expression in osteoblastic cells.
Individualized Treatment of Neovascular Age-Related Macular Degeneration: What are Patients Gaining? Or Losing?
Authors: Stewart Michael
Published: May 2015

The widespread use of drugs that bind diffusible vascular endothelial growth factor (VEGF) has revolutionized the treatment of neovascular age-related macular degeneration (AMD). The pivotal ranibizumab and aflibercept registration trials featured monthly intravitreal injections for 12 months, during which visual acuities and macular edema rapidly improved for the first 3 months and modest gains or stabilization continued until the primary endpoint. In many subsequent trials, patients were evaluated monthly and treated as-needed (PRN) according to the results of visual acuity (VA) testing, fundus examinations and optical coherence tomography scans. Compared to monthly-treated control groups, PRN treated patients require fewer injections during the first year but they also experience smaller VA gains (1–3 letters). A small number of prospective trials that directly compared monthly with PRN therapy showed that VA gains with discontinuous therapy lag slightly behind those achieved with monthly injections. Physicians recognize that monthly office visits with frequent intraocular injections challenge patients’ compliance, accrue high drug and professional service costs, and clog office schedules with frequently returning patients. To decrease the numbers of both office visits and anti-VEGF injections without sacrificing VA gains, physicians have embraced the treat-and-extend strategy. Treat-and-extend has not been studied as rigorously as PRN but it has become popular among both vitreoretinal specialists and patients. Despite the possible risks associated with discontinuous therapy (decreased VA and increased macular fluid), most physicians individualize treatment (PRN or treat-and-extend) for the majority of their patients. This review chapter explores the many advantages of individualized therapy, while balancing these against suboptimal responses due to the decreased frequency of anti-VEGF injections.
Intracranial CNS Manifestations of Myeloid Sarcoma in Patients with Acute Myeloid Leukemia: Review of the Literature and Three Case Reports from the Author’s Institution
Authors: Cervantes Gustavo , Cayci Zuzan
Published: May 2015

Myeloid sarcoma (MS) of the central nervous system (CNS) is a rare presentation of leukemic mass infiltration outside of the bone marrow. It may involve the subperiosteum and dura mater and, on rare occasions, can also invade the brain parenchyma. The disease is most commonly seen in children or young adults; however, it has been described in multiple age groups. MS can be seen in patients with acute myeloid leukemia (AML), chronic myeloid leukemia and other myeloproliferative disorders. This entity has the potential to be underdiagnosed if the MS appearance precedes the first diagnosis of leukemia. The main reason is that their appearance on CT and MRI has a broad differential diagnosis, and proper diagnosis of MS can only be made if the imaging findings are correlated with the clinical history and laboratory findings. Herein, we describe the intracranial CNS manifestations of MS in patients with AML on CT and MRI involving the brain and/or meninges. This study is based on a systematic review of the literature. In addition, three case reports from the author’s institution with AML and intracranial involvement of MS are included. Our aim is to enhance the awareness of this entity among both clinicians and radiologists.
A Review of Multidisciplinary Interventions in Atopic Dermatitis
Authors: Spielman Sara , LeBovidge Jennifer , Timmons Karol , Schneider Lynda
Published: May 2015

Multidisciplinary interventions have been developed for patients with atopic dermatitis (AD) and their families, with the aim of improving outcomes such as disease control, adherence, and quality of life. We reviewed the content of different multidisciplinary approaches to intervention for AD and evidence for their impact on key outcome measures. We also provided data from our multidisciplinary outpatient program for pediatric AD. Studies included in the review suggest benefits of multidisciplinary interventions as models of treatment or adjuncts to standard medical care, with a positive impact on outcomes including disease severity and itching/scratching. There were limitations to existing studies, including heterogeneous methods used to assess quality of life outcomes across studies and lack of controlled studies assessing the outcome of clinical care programs. Further research will be useful in assessing the impact of multidisciplinary interventions on important outcomes such as treatment adherence and sleep, identifying the elements of multidisciplinary interventions that are most critical for improved outcomes, and identifying the best candidates for multidisciplinary intervention approaches.
Impacts of Work Function Variation and Line-Edge Roughness on TFET and FinFET Devices and 32-Bit CLA Circuits
Authors: Chen Yin-Nien , Chen Chien-Ju , Fan Ming-Long , Hu Vita , Su Pin , Chuang Ching-Te
Published: May 2015

In this paper, we analyze the variability of III-V homojunction tunnel FET (TFET) and FinFET devices and 32-bit carry-lookahead adder (CLA) circuit operating in near-threshold region. The impacts of the most severe intrinsic device variations including work function variation (WFV) and fin line-edge roughness (fin LER) on TFET and FinFET device Ion, Ioff, Cg, 32-bit CLA delay and power-delay product (PDP) are investigated and compared using 3D atomistic TCAD mixed-mode Monte-Carlo simulations and HSPICE simulations with look-up table based Verilog-A models calibrated with TCAD simulation results. The results indicate that WFV and fin LER have different impacts on device Ion and Ioff. Besides, at low operating voltage (<0.3 V), the CLA circuit delay and power-delay product (PDP) of TFET are significantly better than FinFET due to its better Ion and Cg,ave and their smaller variability. However, the leakage power of TFET CLA is larger than FinFET CLA due to the worse Ioff variability of TFET devices.
Investigation of the High Mobility IGZO Thin Films by Using Co-Sputtering Method
Authors: Hsu Chao-Ming , Tzou Wen-Cheng , Yang Cheng-Fu , Liou Yu-Jhen
Published: May 2015

High transmittance ratio in visible range, low resistivity, and high mobility of IGZO thin films were prepared at room temperature for 30 min by co-sputtering of Zn2Ga2O5 (Ga2O3 + 2 ZnO, GZO) ceramic and In2O3 ceramic at the same time. The deposition power of pure In2O3 ceramic target was fixed at 100 W and the deposition power of GZO ceramic target was changed from 80 W to 140 W. We chose to investigate the deposition power of GZO ceramic target on the properties of IGZO thin films. From the SEM observations, all of the deposited IGZO thin films showed a very smooth and featureless surface. From the measurements of XRD patterns, only the amorphous structure was observed. We aimed to show that the deposition power of GZO ceramic target had large effect on the Eg values, Hall mobility, carrier concentration, and resistivity of IGZO thin films. Secondary ion mass spectrometry (SIMS) analysis in the thicknesses’ profile of IGZO thin films found that In and Ga elements were uniform distribution and Zn element were non-uniform distribution. The SIMS analysis results also showed the concentrations of Ga and Zn elements increased and the concentrations of In element was almost unchanged with increasing deposition power.
Synthesis, Structural Characterization and Biological Activity of Novel Cyclohexane-1,3-dione Ligands and Their Metal Complexes
Authors: Turan Nevin , Körkoca Hanifi , Adigüzel Ragıp , Çolak Naki , Buldurun Kenan
Published: May 2015

Some new Zn(II) and Cu(II) complexes [Cu(L1)(OAc)2]∙H2O, [Cu(L1)(NO3)H2O]∙NO3∙3.5H2O, [Zn(L1)(NO3)2]∙4.5H2O, [Zn(L1)(OAc)2(H2O)2]∙3H2O, [Cu2(L2)(OAc)4]∙2H2O∙2DMF, [Cu(L2)2]∙2NO3∙1.5DMF∙H2O, [Zn(L2)2(NO3)2]∙DMF and [Zn2(L2)(OAc)4(H2O)4]∙5H2O; L1 = 2-[2-(2-methoxyphenyl)hydrazono]cyclohexane-1,3-dione and L2 = 2-[2-(3-nitrophenyl)hydrazono]cyclohexane-1,3-dione were synthesized and characterized by IR, 1H-NMR,13C-NMR and ultraviolet (UV-Vis.) spectroscopy, elemental analysis, magnetic susceptibility, mass spectrometry and thermogravimetry-differential thermal analysis (TGA-DTA). The synthesized ligands and their complexes were tested for antibacterial activity against Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, and Salmonella typhimurium CCM 583. Some of complexes showed medium-level antibacterial activity against the test bacteria compared with ampicillin.
Essential Oil from Berries of Lebanese Juniperus excelsa M. Bieb Displays Similar Antibacterial Activity to Chlorhexidine but Higher Cytocompatibility with Human Oral Primary Cells
Authors: Azzimonti Barbara , Cochis Andrea , Beyrouthy Marc , Iriti Marcello , Uberti Francesca , Sorrentino Rita , Landini Manuela , Rimondini Lia , Varoni Elena
Published: May 2015

Chlorhexidine (CHX), one of the most effective drugs administered for periodontal treatment, presents collateral effects including toxicity when used for prolonged periods; here, we have evaluated the bactericidal potency and the cytocompatibility of Juniperus excelsa M. Bieb essential oil (EO) in comparison with 0.05% CHX. The EO was extracted from berries by hydrodistillation and components identified by gas chromatography and mass spectrometry. Bacterial inhibition halo analysis, quantitative cell viability 2,3-bis(2-methoxy-4-nitro-5-sulphophenyl)-5-[(phenyl amino) carbonyl]-2H-tetrazolium hydroxide assay (XTT), and colony forming unit (CFU) count were evaluated against the two biofilm formers Aggregatibacter actinomycetemcomitans and Streptococcus mutans. Finally, cytocompatibility was assessed with human primary gingival fibroblasts (HGF) and mucosal keratinocytes (HK). The resulting EO was mainly composed of monoterpene hydrocarbons and oxygenated monoterpenes. An inhibition halo test demonstrated that both bacteria were sensitive to the EO; XTT analysis and CFU counts confirmed that 10-fold-diluted EO determined a statistically significant (p < 0.05) reduction in bacteria count and viability towards both biofilm and planktonic forms in a comparable manner to those obtained with CHX. Moreover, EO displayed higher cytocompatibility than CHX (p < 0.05). In conclusion, EO exhibited bactericidal activity similar to CHX, but a superior cytocompatibility, making it a promising antiseptic alternative to CHX.
Preliminary Finnish Measures of Eating Competence Suggest Association with Health-Promoting Eating Patterns and Related Psychobehavioral Factors in 10–17 Year Old Adolescents
Authors: Tanja Tilles-Tirkkonen , Outi Nuutinen , Sakari Suominen , Jarmo Liukkonen , Kaisa Poutanen , Leila Karhunen
Published: May 2015

Eating competence is an attitudinal and behavioral concept, based on The Satter Eating Competence Model. In adults, it has been shown to be associated with a higher quality of diet. Eating competence or its association with the quality of diet has not been studied in adolescents. The aim of the current study was to explore the utility of using a preliminary Finnish translation of the ecSI 2.0 for evaluating presumed eating competence and its association with food selection, meal patterns and related psychobehavioral factors in 10–17 year old adolescents. Altogether 976 10–17 years old Finnish adolescents filled in the study questionnaire. When exploring the construct validity of ecSI 2.0, the confirmatory factor analysis (CFA) indicated acceptable model fit and all four components of the ecSI 2.0 (eating attitudes, food acceptance, internal regulation of food intake, management of eating context) correlated with each other and were internally consistent. Over half (58%) of the adolescents scored 32 or higher and were thus classified as presumably eating competent (pEC). Eating competence was associated with greater meal frequency, more frequent consumption of vegetables and fruits, and more health-promoting family eating patterns. In addition the pEC, adolescents more often perceived their body size as appropriate, had less often tried to lose weight and had a higher self-esteem and a stronger sense of coherence than the not pEC ones. Family eating patterns and self-esteem were the main underlying factors of eating competence. In conclusion, this preliminary study suggests eating competence could be a useful concept to characterize eating patterns and related behaviors and attitudes in adolescents. However, these preliminary findings need to be confirmed in further studies with an instrument fully validated for this age group.
Multiple-Micronutrient Fortified Non-Dairy Beverage Interventions Reduce the Risk of Anemia and Iron Deficiency in School-Aged Children in Low-Middle Income Countries: A Systematic Review and Meta-Analysis (i–iv)
Authors: Aaron Grant , Dror Daphna , Yang Zhenyu
Published: May 2015

Multiple-micronutrient (MMN) fortification of beverages may be an effective option to deliver micronutrients to vulnerable populations. The aim of the present systematic review and meta-analysis is to evaluate the nutritional impacts of MMN fortified beverages in the context of low-middle income countries. A systematic search of published literature yielded 1022 citations, of which 10 randomized controlled trials (nine in school-aged children and one in pregnant women) met inclusion criteria. Results of school-aged children were included in the meta-analysis. Compared to iso-caloric controls, children who received MMN fortified beverages for 8 weeks to 6 months showed significant improvements in hemoglobin (+2.76 g/L, 95% CI [1.19, 4.33], p = 0.004; 8 studies) and serum ferritin (+15.42 pmol/L, [5.73, 25.12], p = 0.007; 8 studies); and reduced risk of anemia (RR 0.58 [0.29, 0.88], p = 0.005; 6 studies), iron deficiency (RR 0.34 [0.21, 0.55], p = 0.002; 7 studies), and iron deficiency anemia (RR 0.17 [0.06, 0.53], p = 0.02; 3 studies). MMN fortified beverage interventions could have major programmatic implications for reducing the burden of anemia and iron deficiency in school-aged children in low-middle income countries. Additional research is needed to investigate effects on other biochemical outcomes and population subgroups.
An Islamic Perspective in Managing Religious Diversity
Authors: Wani Hilal , Abdullah Raihanah , Chang Lee
Published: May 2015

This paper examines the concept of “diversity” as mentioned in the Qur’an and how commonalities in diverse religions may be used as a model for civilizational dialogue towards achieving harmony. This study reveals that religious and cultural diversity are laws of nature which cannot be changed while the concept of “identity” is a contested issue in modern discourse. Results also show that peace may be established among diverse religions through their commonalities and the best way to exploit these commonalities and to reduce the religious divide is through civilizational dialogue. The Alternative Dispute Resolution (ADR) and other methods for changing the nature of religious differences and reaching a consensus—thus arriving at a peaceful co-existence—are also discussed. It was found that people are often misguided or divided in the name of religion and culture, despite the fact that the philosophy of every religion is based on peace and harmony.
Empirical Radiometric Normalization of Road Points from Terrestrial Mobile Lidar System
Authors: Teo Tee-Ann , Yu Hui-Lin
Published: May 2015

Lidar data provide both geometric and radiometric information. Radiometric information is influenced by sensor and target factors and should be calibrated to obtain consistent energy responses. The radiometric correction of airborne lidar system (ALS) converts the amplitude into a backscatter cross-section with physical meaning value by applying a model-driven approach. The radiometric correction of terrestrial mobile lidar system (MLS) is a challenging task because it does not completely follow the inverse square range function at near-range. This study proposed a radiometric normalization workflow for MLS using a data-driven approach. The scope of this study is to normalize amplitude of road points for road surface classification, assuming that road points from different scanners or strips should have similar responses in overlapped areas. The normalization parameters for range effect were obtained from crossroads. The experiment showed that the amplitude difference between scanners and strips decreased after radiometric normalization and improved the accuracy of road surface classification.
An Improvement of the Radiative Transfer Model Component of a Land Data Assimilation System and Its Validation on Different Land Characteristics
Authors: Lu Hui , Yang Kun , Koike Toshio , Zhao Long , Qin Jun
Published: May 2015

The paper reports the recent progress in the radiative transfer model (RTM) development, which serves as the observation operator of a Land Data Assimilation System (LDAS), and its validation at two Planetary Boundary Layer (PBL) stations with different weather and land cover conditions: Wenjiang station of humid and cropped field and Gaize station of arid and bare soil field. In situ observed micrometeorological data were used as the driven data of LDAS, in which AMSR-E brightness temperatures (TB) were assimilated into a land surface model (LSM). Near surface soil moisture content output from LDAS, together with the one simulated by a LSM with default parameters, were compared to the in-situ soil moisture observation. The comparison results successfully validated the capability of LDAS with new RTM to simulate near surface soil moisture at various environments, supporting that LDAS can generally simulate soil moisture with a reasonable accuracy for both humid vegetated fields and arid bare soil fields while the LSM overestimates near surface soil moisture for humid vegetated fields and underestimates soil moisture for arid bare soil fields.
A New Algorithm of the FPAR Product in the Heihe River Basin Considering the Contributions of Direct and Diffuse Solar Radiation Separately
Authors: Li Li , Du Yongming , Tang Yong , Xin Xiaozhou , Zhang Hailong , Wen Jianguang , Liu Qinhuo
Published: May 2015

It remains a challenging issue to accurately estimate the fraction of absorbed photosynthetically-active radiation (FPAR) using remote sensing data, as the direct and diffuse radiation reaching the vegetation canopy have different effects for FPAR. In this research, a FPAR inversion model was developed that may distinguish direct and diffuse radiation (the DnD model) based on the energy budget balance principle. Taking different solar zenith angles and diffuse PAR proportions as inputs, the instantaneous FPAR could be calculated. As the leaf area index (LAI) and surface albedo do not vary in a short periods, the FPAR not only on a clear day, but also on a cloudy day may be calculated. This new method was used to produce the FPAR products in the Heihe River Basin with the Moderate-Resolution Imaging Spectroradiometer (MODIS) LAI and surface albedo products as the input data source. The instantaneous FPAR was validated by using field-measured data (RMSE is 0.03, R2 is 0.85). The daily average FPAR was compared with the MODIS FPAR product. The inversion results and the MODIS FPAR product are highly correlated, but the MODIS FPAR product is slightly high in forest areas, which is in agreement with other studies for MODIS FPAR products.
A Revised Temporal Scaling Method to Yield Better ET Estimates at a Regional Scale
Authors: Song Yi , Ma Mingguo , Jin Long , Wang Xufeng
Published: May 2015

This study presents a revised temporal scaling method based on a detection algorithm for the temporal stability of the evaporative fraction (EF) to estimate total daytime evapotranspiration (ET) at a regional scale. The study area is located in the Heihe River Basin, which is the second largest inland river basin in China. The remote sensing data and field observations used in this study were obtained from the Heihe Watershed Allied Telemetry Experimental Research (HiWATER) project. The half-hourly EF values (EFEC) calculated using meteorological observations from an eddy covariance (EC) system and an automatic meteorological station (AMS) represented the diurnal pattern of the EF across the majority of the study area. The remotely sensed instantaneous midday EF (EFASTER), which indicates the spatial distribution of the midday EF over the entire study area, was calculated from an Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) image. The temporal stability of EFEC was examined using a detection algorithm. Intervals with inconsistent EFEC values were distinguished from those with consistent EFEC values; the total daytime ET (from 9:00 to 19:00) within these interval types was integrated separately. Validation of the total daytime ET at the satellite pixel scale was conducted using measurements from17 EC towers. Using the detection algorithm for the temporal stability of the EF and dynamic adjustment, the revised temporal scaling method resulted in a root-mean-square error (RMSE) of 0.54 (mm·d−1), a mean relative error (MRE) of 7.26% and a correlation coefficient (Corr.) of 0.81; all of these values were superior to those of the two other methods (i.e., the constant EF and variable EF methods). The revised method easily extends to other areas and exhibits a superior performance in flat and regularly-irrigated farmlands at the regional scale.
Evaluation of Three State-of-the-Art Classifiers for Recognition of Activities of Daily Living from Smart Home Ambient Data
Authors: Nef Tobias , Urwyler Prabitha , Büchler Marcel , Tarnanas Ioannis , Stucki Reto , Cazzoli Dario , Müri René , Mosimann Urs
Published: May 2015

Smart homes for the aging population have recently started attracting the attention of the research community. The “health state” of smart homes is comprised of many different levels; starting with the physical health of citizens, it also includes longer-term health norms and outcomes, as well as the arena of positive behavior changes. One of the problems of interest is to monitor the activities of daily living (ADL) of the elderly, aiming at their protection and well-being. For this purpose, we installed passive infrared (PIR) sensors to detect motion in a specific area inside a smart apartment and used them to collect a set of ADL. In a novel approach, we describe a technology that allows the ground truth collected in one smart home to train activity recognition systems for other smart homes. We asked the users to label all instances of all ADL only once and subsequently applied data mining techniques to cluster in-home sensor firings. Each cluster would therefore represent the instances of the same activity. Once the clusters were associated to their corresponding activities, our system was able to recognize future activities. To improve the activity recognition accuracy, our system preprocessed raw sensor data by identifying overlapping activities. To evaluate the recognition performance from a 200-day dataset, we implemented three different active learning classification algorithms and compared their performance: naive Bayesian (NB), support vector machine (SVM) and random forest (RF). Based on our results, the RF classifier recognized activities with an average specificity of 96.53%, a sensitivity of 68.49%, a precision of 74.41% and an F-measure of 71.33%, outperforming both the NB and SVM classifiers. Further clustering markedly improved the results of the RF classifier. An activity recognition system based on PIR sensors in conjunction with a clustering classification approach was able to detect ADL from datasets collected from different homes. Thus, our PIR-based smart home technology could improve care and provide valuable information to better understand the functioning of our societies, as well as to inform both individual and collective action in a smart city scenario.
Building Keypoint Mappings on Multispectral Images by a Cascade of Classifiers with a Resurrection Mechanism
Authors: Li Yong , Jing Jing , Jin Hongbin , Qiao Wei
Published: May 2015

Inspired by the boosting technique for detecting objects, this paper proposes a cascade structure with a resurrection mechanism to establish keypoint mappings on multispectral images. The cascade structure is composed of four steps by utilizing best bin first (BBF), color and intensity distribution of segment (CIDS), global information and the RANSAC process to remove outlier keypoint matchings. Initial keypoint mappings are built with the descriptors associated with keypoints; then, at each step, only a small number of keypoint mappings of a high confidence are classified to be incorrect. The unclassified keypoint mappings will be passed on to subsequent steps for determining whether they are correct. Due to the drawback of a classification rule, some correct keypoint mappings may be misclassified as incorrect at a step. Observing this, we design a resurrection mechanism, so that they will be reconsidered and evaluated by the rules utilized in subsequent steps. Experimental results show that the proposed cascade structure combined with the resurrection mechanism can effectively build more reliable keypoint mappings on multispectral images than existing methods.
Highly Stable Liquid Metal-Based Pressure Sensor Integrated with a Microfluidic Channel
Authors: Jung Taekeon , Yang Sung
Published: May 2015

Pressure measurement is considered one of the key parameters in microfluidic systems. It has been widely used in various fields, such as in biology and biomedical fields. The electrical measurement method is the most widely investigated; however, it is unsuitable for microfluidic systems because of a complicated fabrication process and difficult integration. Moreover, it is generally damaged by large deflection. This paper proposes a thin-film-based pressure sensor that is free from these limitations, using a liquid metal called galinstan. The proposed pressure sensor is easily integrated into a microfluidic system using soft lithography because galinstan exists in a liquid phase at room temperature. We investigated the characteristics of the proposed pressure sensor by calibrating for a pressure range from 0 to 230 kPa (R2 > 0.98) using deionized water. Furthermore, the viscosity of various fluid samples was measured for a shear-rate range of 30–1000 s−1. The results of Newtonian and non-Newtonian fluids were evaluated using a commercial viscometer and normalized difference was found to be less than 5.1% and 7.0%, respectively. The galinstan-based pressure sensor can be used in various microfluidic systems for long-term monitoring with high linearity, repeatability, and long-term stability.
Surface Acoustic Wave (SAW) Resonators for Monitoring Conditioning Film Formation
Authors: Hohmann Siegfried , Kögel Svea , Brunner Yvonne , Schmieg Barbara , Ewald Christina , Kirschhöfer Frank , Brenner-Weiß Gerald , Länge Kerstin
Published: May 2015

We propose surface acoustic wave (SAW) resonators as a complementary tool for conditioning film monitoring. Conditioning films are formed by adsorption of inorganic and organic substances on a substrate the moment this substrate comes into contact with a liquid phase. In the case of implant insertion, for instance, initial protein adsorption is required to start wound healing, but it will also trigger immune reactions leading to inflammatory responses. The control of the initial protein adsorption would allow to promote the healing process and to suppress adverse immune reactions. Methods to investigate these adsorption processes are available, but it remains difficult to translate measurement results into actual protein binding events. Biosensor transducers allow user-friendly investigation of protein adsorption on different surfaces. The combination of several transduction principles leads to complementary results, allowing a more comprehensive characterization of the adsorbing layer. We introduce SAW resonators as a novel complementary tool for time-resolved conditioning film monitoring. SAW resonators were coated with polymers. The adsorption of the plasma proteins human serum albumin (HSA) and fibrinogen onto the polymer-coated surfaces were monitored. Frequency results were compared with quartz crystal microbalance (QCM) sensor measurements, which confirmed the suitability of the SAW resonators for this application.
Fruit Quality Evaluation Using Spectroscopy Technology: A Review
Authors: Wang Hailong , Peng Jiyu , Xie Chuanqi , Bao Yidan , He Yong
Published: May 2015

An overview is presented with regard to applications of visible and near infrared (Vis/NIR) spectroscopy, multispectral imaging and hyperspectral imaging techniques for quality attributes measurement and variety discrimination of various fruit species, i.e., apple, orange, kiwifruit, peach, grape, strawberry, grape, jujube, banana, mango and others. Some commonly utilized chemometrics including pretreatment methods, variable selection methods, discriminant methods and calibration methods are briefly introduced. The comprehensive review of applications, which concentrates primarily on Vis/NIR spectroscopy, are arranged according to fruit species. Most of the applications are focused on variety discrimination or the measurement of soluble solids content (SSC), acidity and firmness, but also some measurements involving dry matter, vitamin C, polyphenols and pigments have been reported. The feasibility of different spectral modes, i.e., reflectance, interactance and transmittance, are discussed. Optimal variable selection methods and calibration methods for measuring different attributes of different fruit species are addressed. Special attention is paid to sample preparation and the influence of the environment. Areas where further investigation is needed and problems concerning model robustness and model transfer are identified.
The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle
Authors: McKinney Caleb , Hussmann Katherine , McBride Alison
Published: May 2015

The DNA damage response (DDR) maintains genomic integrity through an elaborate network of signaling pathways that sense DNA damage and recruit effector factors to repair damaged DNA. DDR signaling pathways are usurped and manipulated by the replication programs of many viruses. Here, we review the papillomavirus (PV) life cycle, highlighting current knowledge of how PVs recruit and engage the DDR to facilitate productive infection.
Molecular Characterization of a Novel Positive-Sense, Single-Stranded RNA Mycovirus Infecting the Plant Pathogenic Fungus Sclerotinia sclerotiorum
Authors: Liu Rong , Cheng Jiasen , Fu Yanping , Jiang Daohong , Xie Jiatao
Published: May 2015

Recent studies have demonstrated that a diverse array of mycoviruses infect the plant pathogenic fungus Sclerotinia sclerotiorum. Here, we report the molecular characterization of a newly identified mycovirus, Sclerotinia sclerotiorum fusarivirus 1 (SsFV1), which was isolated from a sclerotia-defective strain JMTJ14 of S. sclerotiorum. Excluding a poly (A) tail, the genome of SsFV1 comprises 7754 nucleotides (nts) in length with 83 and 418 nts for 5'- and 3'-untranslated regions, respectively. SsFV1 has four non-overlapping open reading frames (ORFs): ORF1 encodes a 191 kDa polyprotein (1664 amino acid residues in length) containing conserved RNA-dependent RNA polymerase (RdRp) and helicase domains; the other three ORFs encode three putative hypothetical proteins of unknown function. Phylogenetic analysis, based on RdRp and Helicase domains, indicated that SsFV1 is phylogenetically related to Rosellinia necatrix fusarivirus 1 (RnFV1), Fusarium graminearum virus-DK21 (FgV1), and Penicillium roqueforti RNA mycovirus 1 (PrRV1), a cluster of an independent group belonging to a newly proposed family Fusarividae. However, SsFV1 is markedly different from FgV1 and RnFV1 in genome organization and nucleotide sequence. SsFV1 was transmitted successfully to two vegetatively incompatible virus-free strains. SsFV1 is not responsible for the abnormal phenotype of strain JMTJ14.
High-Risk Human Papillomavirus Targets Crossroads in Immune Signaling
Authors: Tummers Bart , Van der Burg Sjoerd
Published: May 2015

Persistent infections with a high-risk type human papillomavirus (hrHPV) can progress to cancer. High-risk HPVs infect keratinocytes (KCs) and successfully suppress host immunity for up to two years despite the fact that KCs are well equipped to detect and initiate immune responses to invading pathogens. Viral persistence is achieved by active interference with KCs innate and adaptive immune mechanisms. To this end hrHPV utilizes proteins encoded by its viral genome, as well as exploits cellular proteins to interfere with signaling of innate and adaptive immune pathways. This results in impairment of interferon and pro-inflammatory cytokine production and subsequent immune cell attraction, as well as resistance to incoming signals from the immune system. Furthermore, hrHPV avoids the killing of infected cells by interfering with antigen presentation to antigen-specific cytotoxic T lymphocytes. Thus, hrHPV has evolved multiple mechanisms to avoid detection and clearance by both the innate and adaptive immune system, the molecular mechanisms of which will be dealt with in detail in this review.
IPNV Antigen Uptake and Distribution in Atlantic Salmon Following Oral Administration
Authors: Chen Lihan , Evensen Øystein , Mutoloki Stephen
Published: May 2015

One impediment to the successful oral vaccination in fish is the hostile stomach environment that antigens must cross. Furthermore, uptake of antigens from the gut to systemic distribution is required for induction of systemic immunity, the dynamics of which are poorly understood. In the present study, groups of Atlantic salmon parr were intubated with live or inactivated infectious pancreatic necrosis virus (IPNV), either orally or anally. At 1, 24 and 72 h post infection (p.i.), the fish were sacrificed. Serum was used for assessing IPNV by ELISA, while formalin-fixed head-kidney, spleen, liver and intestine tissues were used for the demonstration of antigens by immunohistochemistry. Both live and inactivated IPNV antigens were observed in enterocytes of the intestines and in immune cells of the head-kidneys and spleens of all groups. In the liver, no antigens were observed in any of the groups. Significantly higher serum antigen OD values (p < 0.04) were observed in orally- compared to anally-intubated fish. By contrast, no difference (p = 0.05) was observed in tissue antigens between these groups by immunohistochemistry. No significant difference (p = 0.05) in serum antigens was observed between groups intubated with live and inactivated IPNV, while in tissues, significantly more antigens (p < 0.03) were observe in the latter compared to the former. These findings demonstrate that both live and inactivated IPNV are taken up by enterocytes in the intestines of Atlantic salmon, likely by receptor-mediated mechanisms. Higher IPNV uptake by the oral compared to anal route suggests that both the anterior and posterior intestines are important for the uptake of the virus and that IPNV is resistant to gastric degradation of the Atlantic salmon stomach.