bluuebunny/crossref_metadata_2025 huggingface dataset:
ELIXIR pilot action: Marine metagenomics – towards a domain specific set of sustainable services
Authors: Robertsen Espen Mikal , Denise Hubert , Mitchell Alex , Finn Robert D. , Bongo Lars Ailo , Willassen Nils Peder
Published: January 2017

Metagenomics, the study of genetic material recovered directly from environmental samples, has the potential to provide insight into the structure and function of heterogeneous microbial communities.  There has been an increased use of metagenomics to discover and understand the diverse biosynthetic capacities of marine microbes, thereby allowing them to be exploited for industrial, food, and health care products. This ELIXIR pilot action was motivated by the need to establish dedicated data resources and harmonized metagenomics pipelines for the marine domain, in order to enhance the exploration and exploitation of marine genetic resources. In this paper, we summarize some of the results from the ELIXIR pilot action “Marine metagenomics – towards user centric services”.
Are we speaking the same language?
Authors: McIlroy Elaine
Published: January 2017

Customer-facing public sector workers must now speak fluent English. What does this mean for practices?
Pulling strings
Authors: Trowhil Tom
Published: January 2017

With practices focused on managing day-to-day issues, caring for patients and growing the business, finding the time to deal with partners can prove a bit of a handful, writes solicitor Tom Trowhil
Hitting the right note
Authors: Park Maxine
Published: January 2017

A step-by-step guide to avoiding disciplinary pitfalls when recording meetings
New Year, New practice, New horizons
Authors: Hogg Pauline
Published: January 2017

Specialist medical accountant Pauline Hogg gives her views on how practice managers can help improve how their practice looks, feels and operates
Complex? No, it's more complicated than that
Authors: Ainsworth Steve
Published: January 2017

It's all in the name, suggests Steve Ainsworth
Top ten questions: Diphtheria, tetanus and polio
Authors: Umeed Margaret
Published: January 2017

The most commonly used vaccine in a travel consultation is the combined diphtheria, tetanus and polio vaccine – a vital part of the UK immunisation schedule
Pharmacy services: The war goes on
Authors: Ainsworth Steve
Published: January 2017

Practice managers no doubt often reflect that health service planning is an oxymoron. Nothing the NHS plans ever seems to go right, says Steve Ainsworth
Managing practice cash flow problems
Authors: Harnby Phil
Published: January 2017

Specialist medical accountant Phil Harnby explains that long-term planning is key to avoiding unnecessary cash flow problems
The importance of good financial information
Authors: Taylor Keith
Published: January 2017

When the latest NHS guidance asking providers to balance their budgets by the end of 2016/2017, pressure on GP practices' finances is reaching an unprecedented level, says Keith Taylor
The fruits of engagement – 7 bitesize tips
Authors: Hargreaves Ken
Published: January 2017

Ken Hargreaves, outgoing PPG chair at Holycroft Surgery in Keighley, West Yorkshire, offers his tips for a successful GP Patient Participation Group
Top employment law issues
Authors: Symon Liz
Published: January 2017

From social media to changing contracts, MDDUS employment law adviser Liz Symon looks at the most common employment law issues facing practices today
Step change
Authors: Bissett Julie
Published: January 2017

Caring for dementia is all about taking the right path
Cross about infection
Authors: Ainsworthz Steve
Published: January 2017

In today's NHS, rigorous infection control practices are an essential part of everyday practice – but this hasn't always been the case, says Steve Ainsworth
Driving health and safety at work through peer recognition
Authors: Sylvester John
Published: January 2017

Health and safety regulatory requirements affect every workplace to varying degrees, but many employees are not making the connection between policies and good practice in their daily workflow, says John Sylvester
Playing with a full tech
Authors: mith James
Published: January 2017

Technology without training is holding care management services back, says James Smith
Friends and family: Making best use of the FFT
Authors: Hancock Dave
Published: January 2017

And the winner is … Bradford on Avon and Melksham Health Partnership. Who would have thought collecting patient data would become a competition? What lessons can be learned from the contest?
The long game: Travelling with chronic illness
Authors: Patel Dipti
Published: January 2017

Dipti Patel reviews the guidance on pre-travel preparation for travellers with long-term conditions, highlights some of the challenges associated with overseas travel for this group and signposts some useful resources
Top ten questions: The rabies vaccine
Authors: Umeed Margaret
Published: January 2017

Rabies is prevalent in over 150 countries globally and is estimated to cause tens of thousands of deaths each year. Margaret Umeed explains how practices can obtain the vaccine and what practice managers should consider when advising travellers
To test or not to test: Assessing personality traits
Authors: Hancock Dave
Published: January 2017

While various terms such as cognitive psychology, clinical psychology and psychoanalysis maybe familiar, have you ever considered whether aspects of psychology should be part of your role?
Surviving the cut
Authors: Ainsworth Steve
Published: January 2017

Not enough doctors, not enough nurses, not enough dentists. By all accounts, the NHS is on the verge of collapse. Yet one sector is apparently experiencing massive over supply – pharmacies
Parkinson's Law: Will GP workloads ease?
Authors: Ainsworth Steve
Published: January 2017

The government has committed itself to finding an extra 5,000 GPs over the next four years in the hope that an injection of extra manpower (or womanpower) will do the trick. But will that be enough?
Standard lease is draconian
Authors: Cumberlege Justin
Published: January 2017

Justin Cumberlege, a partner in Cripps LLP's healthcare team, advises GP practices to think carefully before signing a lease with NHS Property Services
Forward view: All that glitters …
Authors: Farrell Edwina
Published: January 2017

The promise of extra funding with the publication of the NHS General Practice Forward View has come at a time when models of service delivery are under close scrutiny. But all that glitters may not be gold, says Edwina Farrell
Preventing fraud in general practice
Authors: Taylor Keith
Published: January 2017

Accountant Keith Taylor offers some guidance on how shared accountability and control can help to protect your practice
The unseen pension risks of TUPE
Authors: Marshall Jane
Published: January 2017

The regulations and guidance around pensions in TUPE arrangements contain different provisions and are applicable to different public bodies. It is important to understand the differences, says Jane Marshall
An appointment with … Lorraine Stratulis
Authors: Hancock Dave
Published: January 2017

With patient numbers increasing and difficulty recruiting doctors, this all-female practice instigated an innovative solution
The fight against fake pharmaceuticals
Authors: Fuller Stuart
Published: January 2017

Stuart Fuller reveals the extent of fake goods bought by consumers online, and the consequences for the medical pharmaceutical industry and patients
Funding for practice premises
Authors: Pow Andrew
Published: January 2017

With increasing pressure on primary care, many GP practices are finding that their current premises are too small or simply not fit for purpose, says Andrew Pow
Widening horizons in primary care
Authors: Cusack Carole
Published: January 2017

The current challenges facing practice managers can seem overwhelming – and for many and there is not the head space to look for and implement solutions, says Carole Cusack. What does the future hold for GP services?
More questions than answers
Authors: Moffat Polly
Published: January 2017

Chief Executive of the NHS, Simon Stevens, has suggested that NHS workers from the EU are still welcome, despite the recent Brexit vote
An appointment with … Steve Ellis
Authors: Hancock Dave
Published: January 2017

Years ago, a general practice in Shrewsbury split into two, and now it has merged with another practice. Practice Manager, Steve Ellis, explains why and how
Advice for the older traveller
Authors: Grieve Sandra
Published: January 2017

Older people travel widely. Age is not a barrier, but particular issues may need consideration, says Sandra Grieve
Dementia services in primary care
Authors: McNamara George
Published: January 2017

What is good for your heart is good for the brain, and promoting this important public health message in GP practices is one of the best ways to reduce the number of people living with dementia in the future, says George McNamara
Auto-enrolment: Your new pension duties explained
Authors: Gascoyne-Richards Rebecca
Published: January 2017

All eligible UK employees now need to be included in a workplace pension. Rebecca Gascoyne-Richards gives an update on how the new rules affect GP practices
Does good governance matter?
Authors: Cumberlege Justin
Published: January 2017

Justin Cumberlege, a partner with healthcare specialist Cripps, explains why GP federations need to maintain good governance
Managing health and safety in practice
Authors: Hancock Dave
Published: January 2017

What could – and should – you be doing to comply with health and safety requirements on an ongoing basis? Dave Hancock summarises the main recommendations
A numbers game
Authors: Ainsworth Steve
Published: January 2017

When national data are released and the figures appear alarming, is the ensuing media panic justified? Steve Ainsworth explains why some statistics are more significant than others
A democratic approach to delivering change
Authors: Mckenzie Scott
Published: January 2017

Why is real, sustainable change in the NHS like the pot of gold at the end of the rainbow? Scott Mckenzie looks at how practices should encourage inclusive engagement
Caring conversations
Authors: Dewar Belinda
Published: January 2017

Professor Belinda Dewar explains how her research into conversations in care settings has helped to create Putting Caring Conversations into Practice, a free online training resource to help promote person-centred care in GP practices
A new approach to mental health in primary care
Authors: Chana Nav
Published: January 2017

Nav Chana, Chairman of the National Association for Primary Care, reflects on the NHS Forward View for Mental Health and the importance of primary care in supporting patients with mental health issues
Top ten questions: Hepatitis A
Authors: Umeed Margaret
Published: January 2017

Hepatitis A, a viral liver disease, is one of the most common travel-related, vaccine-preventable diseases, says Margaret Umeed. How should practices obtain the vaccine?
The cost of dispensing medications
Authors: Koopowitz Philip
Published: January 2017

With ever-increasing pressures on general practice finances, it is vital for practices to look at every aspect of their income generation to maintain their resilience, says Philip Koopowitz
Changing cultures: Bullying in the NHS
Authors: Carter Madeline
Published: January 2017

Despite increasing awareness of the problem, and recognition of the need for change, levels of bullying in the NHS remain stubbornly high, says Madeline Carter
Ready for more locums in your practice?
Authors: Rigby Barry
Published: January 2017

Accountant Barry Rigby has an update for practice managers on how to manage locum pay, tax and pension contributions
The detox delusion
Authors: Moffat Polly
Published: January 2017

January for many involves plans to cleanse the body of the excesses of Christmas – but can the detox be dangerous?
Two new species of Otiorhynchus Germar, 1822 (Tecutinus Reitter, 1912) from south-western Anatolia (Coleoptera, Curculionidae: Entiminae)
Authors: Germann Christoph
Published: January 2017

Otiorhynchus (Tecutinus) gultekini sp. nov. from Geyik Dağları and O. (Tecutinus) marggii sp. nov. from Bey Dağları, both from south-western Turkey, are described. Otiorhynchus gultekini sp. nov. is close to O. riedeli Braun, 1989 and O. ikisderensis Smreczyński, 1970 whereas O. marggii sp. nov. is morphologically close to O. brevicornis Boheman, 1842 and O. staveni Braun, 2000. All species of the subgenus are keyed and mapped.
Survival-Related Autophagic Activity Versus Procalcific Death in Cultured Aortic Valve Interstitial Cells Treated With Critical Normophosphatemic-Like Phosphate Concentrations
Authors: Bonetti Antonella , Della Mora Alberto , Contin Magali , Gregoraci Giorgia , Tubaro Franco , Marchini Maurizio , Ortolani Fulvia
Published: January 2017

Valve dystrophic calcification is a common disorder affecting normophosphatemic subjects. Here, cultured aortic valve interstitial cells (AVICs) were treated 3 to 28 days with phosphate (Pi) concentrations spanning the normal range in humans (0.8, 1.3, and 2.0 mM) alone or supplemented with proinflammatory stimuli to assess possible priming of dystrophic-like calcification. Compared with controls, spectrophotometric analyses revealed marked increases in calcium amounts and alkaline phosphatase activity for 2.0-mM-Pi-containing cultures, with enhancing by proinflammatory mediators. Ultrastructurally, AVICs treated with low/middle Pi concentrations showed an enormous endoplasmic reticulum (ER) enclosing organelle debris, so apparently executing a survival-related atypical macroautophagocytosis, consistently with ultracytochemical demonstration of ER-associated acid phosphatase activity and decreases in autophagosomes and immunodetectable MAP1LC3. In contrast, AVICs cultured at 2.0-mM Pi underwent mineralization due to intracellular release and peripheral layering of phospholipid-rich material acting as hydroxyapatite nucleator, as revealed by Cuprolinic Blue and von Kossa ultracytochemical reactions. Lack of immunoblotted caspase-3 cleaved form indicated apoptosis absence for all cultures. In conclusion, fates of cultured AVICs were crucially driven by Pi concentration, suggesting that serum Pi levels just below the upper limit of normophosphatemia in humans may represent a critical watershed between macroautophagy-associated cell restoring and procalcific cell death.
Consumption of energy-dense, nutrient-poor foods and hypertension in obese children
Authors: Sulchan Mohammad
Published: January 2017

Background Obesity has become an increasingly important medicalproblem in children. Obesity-induced hypertension in childhoodshould be considered as a chronic medical condition that is likelyto require long-term management of dietary patterns, especially forenergy-dense, nutrient-poor (EDNP) food consumption.Objective To examine the contribution ofEDNP foods to dailyenergy and macronutrient intakes and to examine the relationshipbetween intake of EDN P foods and the prevalence of hypertensionin children.Methods Four hundred and forty children were randomly selectedto participate. Weight and height were measured with precisionelectronic scales and fixed microtoise, respectively. Blood pressure(BP) measurements were performed by standard procedure. A24-hour dietary recall was obtained by a trained interviewer todetermine the intake of EDNP foods, which were clas sified to 4major groups: visible fat, sweeteners, desserts, or salty snacks.The difference in mean was evaluated using paired Ttest.Logistic models were fitted to assess for an association betweenhypertension and the various characteristics.Results The proportion of children who were overweight (includingobese) was 23 .2%. The prevalence of elevated BP was 10.5%, similarin boys and girls, with most of them having isolated elevated sys to lieBP. There was a relationship between BP and body mass index(BMI) in all children. Approximately 27% of total daily energyintake was contributed by all EDNP foods. Of the EDNP foodsubgroups examined, dessert and sweeteners contributed nearly20% of total daily energy intake. In the highest one-third of subjectswho consumed EDNP food, these foods provided 49% of total dailycarbohydrate intake and 34% of total daily fat intake.Conclusion Eating patterns ofEDNP foods provide 49% of totaldaily carbohydrate intake and 34% of total daily fat intake. ThisEDNP food is independently associated with hypertension inchildren.
Effectiveness of amitriptyline for treating functional dyspepsia in adolescents
Authors: Mustawa Indra , Supriatmo Supriatmo , Hakimi Hakimi , Sinuhaji Atan Baas
Published: January 2017

Background Functional dyspepsia is common among adolescents. Pain reduces children’s quality of life, psychosocial functioning, and school attendance. Amitriptyline is assumed to be one of the alternative treatments in functional dyspepsia.Objective To investigate the effectiveness of amytriptyline as a treatment  for  functional dyspepsia in adolescents.Methods We conducted a randomized, single-blind, controlled trial from January to March 2011 in junior and senior high school students in Dobo City, Aru Island District, Maluku Province. Adolescents suffering from functional dyspepsia and who fulfilled the inclusion criteria were eligible for the study. Subjects were randomized into two groups. Each group received 10 mg (for body weight < 35 kg) or 20 mg (for body weight ≥ 35 kg) amitriptyline or placebo once per day for 28 days. Pain frequency was measured in terms of abdominal pain episodes per month, and duration was measured in minutes. Data were analyzed using t-test.Results Eighty-eight students participated in this study: the amitriptyline group (43 subjects) and the placebo group (45 subjects). There were no statistically significant differences between the amitriptyline and placebo groups in frequency (P=0.777; 95%CI -0.846 to 1.129) or duration (P=0.728) of abdominal pain after treatment.Conclusion  Amitriptyline is not more effective than placebo for treating functional dyspepsia in adolescents.
Comparison of ventilation parameters and blood gas analysis in mechanically-ventilated children who received chest physiotherapy and suctioning vs. suctioning alone
Authors: Elizabeth Monalisa , Yoel Chairul , Ali Muhammad , Loebis M. Sjabroeddin , Arifin Hasanul , Sianturi Pertin
Published: January 2017

Background Chest physiotherapy and suctioning are routine methods for airway clearance in mechanically-ventilated children. However, chest physiotherapy has not been confirmed to affect ventilation parameters, such as tidal volume (TV), peak inflation pressure (PIP), peak inspiratory flow (PIF), and peak expiratory flow (PEF), as well as blood gas analysis (BGA) values in pediatric intensive care unit (PICU) patients.Objective To determine the efficacy of chest physiotherapy and suctioning vs. suctioning alone for improving the mechanical ventilation parameters and BGA.Methods This randomized, single-blind, clinical trial was conducted from November 2012 to June 2013 in the PICU at Haji Adam Malik Hospital, Medan. A total of 40 mechanically-ventilated pediatric patients were enrolled and divided into either the chest physiotherapy and suctioning group (24 subjects) or the suctioning alone group (16 subjects). Subjects underwent treatment, followed by monitoring of their ventilation parameters and blood gas analyses. Data were analyzed by independent t-test and Mann-Whitney test.Results Subjects comprised of 23 boys and 17 girls, with an age range of 1–204 months. After the respective treatments (chest physiotherapy and suctioning vs. suctioning alone), the ventilation parameters were as follows: median TV (60.0 vs. 56.5 mL, respectively; P=0.838), median PEF (10.4 vs. 10.8 I/s, respectively; P=0.838), median PIF (7.4 vs. 8.2 I/s, respectively; P=0.469), and mean PIP (17.3 vs. 15.6 cmH2O, respectively; P=0.23). The BGA values were: median pH (7.4 vs. 7.3, respectively; P=0.838), median pCO2 (38.4 vs. 36.2 mmHg, respectively; P=1.000), mean pO2 (136.6 vs. 139.2 mmHg, respectively; P=0.834), median HCO3 (20.4 vs. 22.7 mmol/L, respectively; P=0.594), median TCO2 (22.0 vs. 23.7 mmol/L, respectively; P=0.672), mean BE (-4.3 vs. -3.1 mmol/L, respectively; P=0.629), and median O2 saturation  (98.5 vs. 98.3 %, respectively; P=0.967).Conclusion In mechanically-ventilated children in the PICU, ventilation parameters and BGA values are not significantly different between subjects who received both chest physiotherapy and suctioning and those who received suctioning alone.
Comparison of urine neutrophil gelatinase-associated lipocalin to serum creatinine to assess kidney function in neonatal asphyxia
Authors: Tanzil Winston Leonardo , Wilar Rocky , Mantik Max Frans Josef , Umboh Adrian , Tatura Suryadi Nicolaas Napoleon
Published: January 2017

Background Infants with neonatal asphyxia have multiorgan damage, such as to the kidneys (50%), central nervous system (28%), cardiovascular system (25%), and lungs (23%). Neonatal asphyxia reduces kidney perfusion, often leading to acute kidney injury (AKI) after asphyxia. Neutrophil gelatinase-associated lipocalin (NGAL) levels in the blood, urine and kidney tissue increased rapidly in AKI. Urinary NGAL is proposed to have better performance in diagnosing AKI than creatinine due to its earlier, rapid level increase and it is less invasive.Objective To compare urinary NGAL to serum creatinine as a marker to assess kidney function in neonatal asphyxia.Methods Diagnostic comparison study with cross-sectional design was performed at neonatal intensive care unit (NICU) of Prof. Dr. R. D. Kandou Hospital, Manado from November 2015 to February 2016. All subjects had neonatal asphyxia. Data were analyzed using descriptive analysis, receiver-operator characteristic (ROC) curve, and Z-test.Results Urinary NGAL with cut-off point of 652.24 ng/mL can predict AKI in neonates with asphyxia with 100% sensitivity, 75% specificity, 52.3% positive predictive value, and 100% negative predictive value. Chi-square test resulted in a value of x2 = 20.036, P=0.0001).This shows that urinary NGAL levels >652,24 ng/mL can predicts AKI by 20 times in infants with neonatal asphyxia. So, urinary NGAL performs better than serum creatinine, therefore it can replace serum creatinine as an alternative non-invasive diagnostic test for diagnosing AKI in infants with neonatal asphyxia.Conclusion The diagnostic value of urinary NGAL is higher than that of serum creatinine in assessing kidney function in neonatal asphyxia.
Faktor Prognosis Derajat Keparahan Infeksi Dengue
Authors: Yulianto Arie , Laksono Ida Safitri , Juffrie Mohammad
Published: January 2017

Latar belakang. Infeksi virus dengue (IVD) bersifat akut dan dinamis, perjalanan klinisnya terkadang sulit diprediksi sehingga berakibat keterlambatan pengelolaan. Maka perlu diteliti parameter klinis dan laboratoris di fase kritis / defervescence untuk memprediksi derajat keparahan infeksi dengue.Tujuan. Mengetahui parameter klinis dan laboratoris sebagai faktor prognosis derajat keparahan infeksi dengue.Metode. Penelitian kohort retrospektif, menggunakan data rekam medik pasien anak IVD yang dirawat di RSUP Dr. Sardjito Yogyakarta dari Januari 2014 – Desember 2015. Faktor prognosis yang diteliti adalah usia, jenis kelamin, tanda klinis warning signs, serta laboratorium. Kriteria eksklusi adalah adanya penyakit hematologi dan penyakit jantung bawaan. Analisis statistik denganmetode regresi logistik.Hasil. Di antara 188 pasien yang memenuhi kriteria penelitian, 56 (30%) didiagnosis demam dengue (DD), 58 (31%) demam berdarah dengue derajat 1 – 2 (DBD), dan 74 (39%) sindrom syok dengue (SSD). Analisis multivariat menunjukkan nyeri perut (OR 5,06, IK 95%: 1,72;14,87), hepatomegali >2 cm (OR 7,57, IK 95%: 2,86;20,02), hematokrit >45% (OR 5,10, IK 95%: 1,74;14,95), dan trombosit ≤50.000/uL (OR 17,80, IK 95%: 3,78;83,80) merupakan faktor prognosis independen derajat keparahan infeksi dengueKesimpulan. Nyeri perut, hepatomegali >2 cm, hematokrit >45% dan trombosit ≤50.000/uL di fase defervescence merupakan faktor prognosis independen terjadinya infeksi dengue yang lebih berat (DBD dan SSD).
Kelainan Kardiovaskular pada Anak dengan Berbagai Stadium Penyakit Ginjal Kronik
Authors: Pabuti Aumas , Sekarwana Nanan , Trihono Partini P
Published: January 2017

Latar belakang. Penyakit kardiovaskular (PKV) merupakan penyebab orbiditas dan mortalitas tersering pada penyakit ginjal kronik (PGK) anak. Hipertrofi ventrikel kiri (LVH) dan disfungsi diastolik paling awal terlihat.Tujuan. Mengetahui proporsi PKV pada PGK stadium 1, hubungan stadium PGK dengan LVH, dan disfungsi jantung.Metode. Penelitian potong lintang analitik komparatif 26 subjek PGK anak di RS M Djamil Padang/ RS Hasan Sadikin Bandung. Dilakukan pemeriksaan urinalisis, hematologi rutin, ureum, kreatinin (eLFG), EKG, foto toraks, ekokardiografi. LVH dengan ekokardiografi bila left ventricular mass index (LVMI) >persentil 95 (38g/h2,7). Uji stastistik bermakna bila p<0,05.Hasil. Rerata umur subjek 9,1(3,8) tahun. LVH pada 1 dari 3 subjek PGK stadium 1 dan 61,5% pada PGK seluruh stadium, terbanyak stadium 5. Tidak terdapat hubungan bermakna stadium PGK dengan LVH (p=0,055), disfungsi diastolik (p=0,937) dan disfungsi sistolik (p=0,929).Kesimpulan. Pada PGK stadium 1 ditemukan LVH dan disfungsi diastolik. Tidak terdapat hubungan antara stadium PGK dengan LVH dan disfungsi jantung.
Status Nutrisi sebagai Faktor Risiko Sindrom Syok Dengue
Authors: Buntubatu Sarah , Arguni Eggi , Indrawanti Ratni , Laksono Ida Safitri , Prawirohartono Endy P.
Published: January 2017

Latar belakang. Risiko kematian pada anak dengan sindrom syok dengue (SSD) tinggi. Obesitas diduga sebagai faktor risiko SSD tetapi hasil penelitian sebelumnya masih kontroversial.Tujuan. Mengevaluasi overweight atau obes sebagai faktor risiko SSD pada anak.Metode. Penelitian case control pada anak (0-18 tahun) yang dirawat di RSUP Dr. Sardjito Yogyakarta dari bulan April 2012 sampai Maret 2015 dengan infeksi dengue, yang ditegakkan berdasarkan kriteria WHO 2011 dan hasil uji serologi darah atau NS1. Analisis statistik dikerjakan dengan analisis multivariat dan stratifikasi. Kemaknaan faktor risiko dilaporkan sebagai odds ratio (OR) denganinterval kepercayaan 95%.Hasil. Dilaporkan 264 anak terdiri dari 88 kasus (SSD) dan 176 kontrol (non SSD) diikutkan dalam penelitian ini. Anak dengan overweight atau obesitas mempunyai risiko SSD 2,29 kali dibanding bukan overweight atau obes OR=2,29; IK95%:1,24-4,22) dan perempuan mempunyai risiko SSD 1,84 kali lebih tinggi dibanding laki-laki (OR=1,84; IK95%:1,08-3,14). Jumlah trombositmerupakan modifier, yaitu anak overweight atau obes dengan angka trombosit <20.000/μL mempunyai risiko 3,26 kali dibanding anak dengan SSD dengan overweight atau obes dengan angka trombosit ≥20.000/μL (OR=3,26;IK95%:1,22-8,72).Kesimpulan. Overweight atau obes dan jenis kelamin perempuan merupakan faktor risiko untuk SSD dan jumlah trombosit <20.000 /μL merupakan modifier.
Report of a rare case of hand-foot-mouth disease in a adult woman with systemic arthritis
Authors: Nóbrega Luciana Eloísa da Silva Castro , De Oliveira Viviane Alves , De Oliveira Patrícia Teixeira , Da Silveira Éricka Janine Dantas , De Medeiros Ana Myriam Costa
Published: January 2017

Hand-foot-mouth disease (HFMD) is a highly infectious disease, rare in adults which usually presents a painfull stomatitis. We describe a rare case of HFMD in a 34-year-old woman with medical history of recent intestinal infection and systemic arthritis with only oral and hands involvement. Additionally, we discuss diagnosis and treatment of this disease and reinforce the importance of the correct diagnosis because delayed diagnosis can cause spread of the disease.Keywords: Adult; Arthritis; Mouth diseases.
Prevalence of malocclusion in people with disabilities
Authors: Cuoghi Osmar Aparecido , Faria Lorraine Perciliano , Micheletti Kelly Regina , Miranda-Zamalloa Yesselin Margot , De Mendonça Marcos Rogério
Published: January 2017

Objective: To evaluate the prevalence of malocclusion in patients with disabilities. Material and Methods: The sample consisted in 98 patients of who had a previous diagnosis of disability. Patientes were divided into three groups: Intelectual Disabilities (ID), Cerebral Palsy (CP) and Down Syndrome (DS). They were evaluated according to Angle malocclusion classification, presence or absence of posterior crossbite, anterior crossbite and anterior open bite. Statistical analysis of the data was performed using the Kruskal Wallis test at 5% significance level. Results: Class II malocclusion was more frequent in the three groups (CP 45.45%, ID 40.43% and DS 50.00%); the anterior and the posterior crossbite were more prevalent in DS (p < 0.0001). The anterior open bite was more prevalent in CP (p < 0.0001).  Conclusion: Patients with disabilities have high rate of malocclusion and understanding this condition is essential to establish appropriate treatment.Keywords: Orthodontics; Malocclusion; People with disabilities.
Prevalence of oral impacts on daily performances (OIDP) of elderly people in Curitiba – PR
Authors: Burci Lígia Moura , Miguel Yasmin Dallarmi , Miguel Obdulio Gomes , Souza Astrid Wiens , Dias Josiane de Fátima Gaspari , Miguel Marilis Dallarmi
Published: January 2017

This study aimed to investigate the prevalence of oral health impact on the daily performance of Brazilian elderly, living in the city ofCuritiba – PR. The oral health-related quality of life (OHRQoL) of 129 elderly people aged from 60 to 80 years was assessed. Also, the influence of gender, income, attendance to the dentist, self-assessment of health, and social-demographic features were verified. Oral health influenced in 83.72%the daily routine of the participants. The lack of compliance to dental treatment and the difficulty in oral health self-perception as integrate part of general health were associated to the greatest interference.Thus, we recommended that the self-perception of the individuals is considered simultaneously to the clinical condition to tailor oral health actions targeted to priority groups.Keywords: Oral health; Elderly; Quality of life.
El fondo del paisaje: una pauta de lectura paisajística del cine ruso y soviético a partir del concepto de fondo como categoría estética
Authors: Muguiro Carlos
Published: January 2017

La idea de fondo (horizonte) es consustancial al nacimiento del paisaje en Occidente, un concepto que el cine hereda y asume desde sus orígenes. Este artículo plantea específicamente la posibilidad de acercarse, a partir de esta figura, a la representación de la naturaleza en el cine ruso y soviético. El artículo desarrolla la idea de que el fondo es una categoría estética en sí misma a partir de la cual se puede establecer una pauta de análisis diacrónico e histórico de dicha cinematografía. Desde un punto de vista metódologico, el artículo se basa en la doble distinción planteada por Maurizia Natali entre la figura y el fondo y el fondo del fondo. Temporalmente, se centra específicamente en las virtualidades del fondo hasta la consolidación del Realismo Socialista a mediados de los años 30 del pasaso siglo.
A revisitação da paisagem nas longas-metragens de Manuel Guimarães
Authors: Vieira da Silva Tiago
Published: January 2017

A obra de Manuel Guimarães destaca-se no cinema português como uma nova e singular forma de representar a realidade nacional até então muito “forjada” segundo os princípios e valores prezados pelo Estado Novo. Neste contexto, a paisagem revela-se um elemento crucial na subversão das relações humanas com o território, e na própria representação do ambiente físico. O cinema de Manuel Guimarães distingue-se muito através do redimensionamento espacial que, ao conceder novos significados ao território, vai também apresentar galerias de personagens que se diferenciam das que preenchem o cinema do período. A revisitação da paisagem nas longas-metragens de Manuel Guimarães propõe-se analisar a maneira como o cineasta recodifica as paisagens no seu cinema, numa tentativa de contestar a utopia estabelecida pelo regime.
Olhar o céu, ouvir a terra: anotações sobre corpo, memória e paisagem no cinema de James Benning e de Cao Guimarães
Authors: Ribeiro Ana Costa
Published: January 2017

Através da abordagem de quatro filmes, a autora ressalta a importância das poéticas do deslocamento nas relações entre corpo, memória e paisagem. Seguindo o pensamento dos filósofos franceses Gilles Tiberghien e Anne Cauquelin, a paisagem é pensada como um meio ambiente físico que faz surgir uma relação. A ideia da paisagem como uma relação permite um avanço para uma reflexão que se desenvolve no texto através da noção de vestígio. Baseada no pensamento do filósofo Emmanuel Lévinas sobre esse conceito, abordam-se dois trabalhos do artista norte-americano James Benning e outros tantos do artista brasileiro Cao Guimarães. Desse modo, identifica-se, na organização de vestígios, uma tendência recorrente na produção audiovisual contemporânea.
Investigações sobre 'slowness'
Authors: Ribas Daniel
Published: January 2017

Recensão crítica do livro Slow Cinema, editado por Tiago de Luca & Nuno Barradas Jorge.
A Comparison of the Neuroprotective Efficacy of Newly Developed Oximes (K156, K203) and Currently Available Oximes (Obidoxime, HI-6) in Cyclosarin-poisoned Rats
Authors: Kassa Jiří , Žďárová Karasová Jana , Tesařová Sandra , Kuča Kamil , Musílek Kamil
Published: January 2017

The neuroprotective effects of newly developed oximes (K156, K203) and currently available oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with cyclosarin were studied. The cyclosarin-induced neurotoxicity was monitored using a functional observational battery 24 hours after cyclosarin challenge. The results indicate that a newly developed oxime K156 is able to counteract slightly cyclosarin-induced neurotoxicity while another newly developed oxime K203 is completely ineffective in reducing cyclosarin-induced neurotoxic signs and symptoms. The neuroprotective efficacy of K156 is comparable with commonly used obidoxime and oxime HI-6. Thus, none of the newly developed oximes achieves better neuroprotective efficacy than both commonly used oximes. They are therefore not suitable replacements for antidotal treatment of acute poisonings with cyclosarin.
Unusual Manifestation of Anaplastic Thyroid Cancer
Authors: Haas Vojtěch , Čelakovský Petr , Brtková Jindra , Hornychová Helena
Published: January 2017

Introduction: The authors present a rare case of a patient with symptoms consistent with retropharyngeal abscess. The diagnosis of anaplastic thyroid cancer was made after surgery and subsequent histological examination. Case report: An 80-year-old woman was referred to Dpt. of Otolaryngology, Head and Neck Surgery, Charles University Medicine Faculty, Teaching Hospital in Hradec Králové with odynophagia and pain in the left side of the neck. The patient had pronounced swelling of the left side of her neck. We could also see swelling of the posterior pharyngeal wall, more pronounced on the left side. Inflammation markers were markedly elevated. Administration of antibiotics intravenously (amoxicillin combined with clavulan acid and gentamicin) was started. A computer tomography investigation (CT) was performed and a retropharyngeal abscess was found. The existence of a tumour was considered as well. An acute endoscopic examination and a puncture of the retropharyngeal space at the site of the swelling were performed, but no pus or any other liquid was found. On the sixth day of hospitalization a second CT scan was performed. As the retropharyngeal mass was still present along with continually elevated inflammatory markers, surgical revision of the retropharyngeal space from an external approach was performed. No abscess formation was found. During the surgery, retropharyngeal lymph nodes were removed for histological examination. The histological examination of the lymph nodes identified metastasis of anaplastic thyroid cancer. Conclusions: The differential diagnosis of diseases affecting deep neck structures can be very difficult. Symptoms of inflammation dominating in the clinical picture do not exclude the possibility of malignancy. The most relevant imaging examination seems to be contrast enhanced computer tomography or magnetic resonance imaging.
Interpreting the Pore Structure of Hydrating Cement Phases Through a Synergistic Use of the Powers-Brownyard Model, Hydration Kinetics, and Thermodynamic Calculations
Authors: Jafari Azad V. , Suraneni P. , Isgor O. B. , Weiss W. J.
Published: January 2017

The Powers-Brownyard model is an analytical tool that is widely used to quantify the volume of gel solids, gel pores, capillary water, and unhydrated cement during the hydration process. These parameters, specifically the capillary and gel pore volumes, are related to important hardened concrete properties, such as shrinkage, freeze-thaw, transport, and strength. While the Powers-Brownyard model has many applications, it does not provide detailed solid phase assemblage information, and it can only be used for ordinary portland cement. In contrast, thermodynamic modeling can predict solid phase assemblage for a wide range of cementitious binders, but does not provide information on the resulting pore structure. This work combined the Powers-Brownyard model, hydration kinetics, and thermodynamic calculations to predict capillary and gel porosity, chemical shrinkage, and volumes of all hydrated and unhydrated phases for plain cement pastes without the need for additional information such as pore size distributions. This new model has the advantages of both the Powers-Brownyard model and thermodynamic modeling, and is a powerful tool, which the authors envision to be used to further advance the understanding of durability of cementitious materials.
Why Are Multiracial Communities So Dangerous?
Authors: Sánchez George J.
Published: January 2017

This essay was the author’s presidential address at the annual meeting of the Pacific Coast Branch, American Historical Association, in Waikoloa Beach, Hawai’i, on August 6, 2016. The address compares three multiracial communities—in Boyle Heights, California; Cape Town, South Africa; and various sites in Hawai’i—and asks why these areas often sparked controversy and were considered dangerous by the powers governing these societies. How these communities became multiracial through labor migration and urban land policies is explored, as well as the nature of interracial life that was created. Each of these communities shares a common history of interracial radicalism that threatened white supremacy, as well as confronting policies of forced removals that attempted to destroy their multiracial nature. Finally, the address, given in Hawai’i at the end of the Obama presidency, addresses the importance of keeping local histories alive through projects of historical memory and museums of conscience.
Alternative Wests
Authors: Isenberg Andrew C. , Richards Thomas
Published: January 2017

The mid-nineteenth century territorial growth of the United States was complex and contradictory. Not only did Mexico, Britain, and Native Americans contest U.S. territorial objectives; so, too, did many within the United States and in some cases American western settlers themselves. The notion of manifest destiny reflects few of these complexities. The authors argue that manifest destiny was a partisan idea that emerged in a context of division and uncertainty intended to overawe opponents of expansion. Only in the early twentieth century, as the United States had consolidated its hold on the North American West and was extending its power into the Caribbean and Pacific, did historians begin to describe manifest destiny as something that it never was in the nineteenth century: a consensus. To a significant extent, historians continue to rely on the idea to explain U.S. expansion. The authors argue for returning a sense of context and contingency to the understanding of mid-nineteenth-century U.S. expansion.
Differential expression of CART in ewes with differing ovulation rates
Authors: Juengel Jennifer L , French Michelle C , Quirke Laurel D , Kauff Alexia , Smith George W , Johnstone Peter D
Published: January 2017

We hypothesised that cocaine- and amphetamine-regulated transcript (CARTPT) would be differentially expressed in ewes with differing ovulation rates. Expression of mRNA forCARTPT, as well asLHCGR,FSHR,CYP19A1andCYP17A1was determined in antral follicles ≥1 mm in diameter collected during the follicular phase in ewes heterozygous for the Booroola and Inverdale genes (I+B+; average ovulation rate 4) and ++ contemporaries (++; average ovulation rate 1.8). In ++ ewes (n = 6),CARTPTwas expressed in small follicles (1 to <3 mm diameter), where 18.8 ± 2.5% follicles expressedCARTPT. CART peptide was also detected in follicular fluid of some follicles of ++ ewes. In I+B+ ewes, 5/6 ewes did not have any follicles that expressedCARTPT, and no CART peptide was detected in any follicle examined. Expression pattern ofCYP19A1differed between I+B+ and ++ ewes with an increased percentage of small and medium follicles (3 to <4.5 mm diameter) but decreased percentage of large follicles (≥4.5 mm diameter) expressingCYP19A1in the I+B+ ewes. Many of the large follicles from the I+B+ ewes appeared non-functional and expression ofLHCGR,FSHR,CYP17A1andCYP19A1was less than that observed in ++ ewes. Expression ofFSHRandCYP17A1was not different between groups in small and medium follicles, butLHCGRexpression was approximately double in I+B+ ewes compared to that in ++ ewes. Thus, ewes with high ovulation rates had a distinct pattern of expression ofCARTPTmRNA and protein compared to ewes with normal ovulation rates, providing evidence for CART being important in the regulation of ovulation rate.
Disparities in HIV/AIDS Risk Behaviors After Youth Leave Detention: A 14-Year Longitudinal Study
Authors: Abram Karen M. , Stokes Marquita L. , Welty Leah J. , Aaby David A. , Teplin Linda A.
Published: January 2017

OBJECTIVES:

To examine changes in the prevalence of 15 HIV/AIDS sex and drug risk behaviors in delinquent youth during the 14 years after they leave detention, focusing on sex and racial/ethnic differences.

METHODS:

The Northwestern Juvenile Project, a prospective longitudinal study of 1829 youth randomly sampled from detention in Chicago, Illinois, recruited between 1995 and 1998 and reinterviewed up to 11 times. Independent interviewers assessed HIV/AIDS risk behaviors using the National Institutes on Drug Abuse Risk Behavior Assessment.

RESULTS:

Fourteen years after detention (median age, 30 years), one-quarter of males and one-tenth of females had >1 sexual partner in the past 3 months. One-tenth of participants reported recent unprotected vaginal sex with a high-risk partner. There were many sex and racial/ethnic differences. For example, African American males had 4.67 times the odds of having >1 partner than African American females (95% confidence interval [CI], 3.22–6.76). Over time, compared with non-Hispanic white males, African American males had 2.56 times the odds (95% CI, 1.97–3.33) and Hispanic males had 1.63 times the odds (95% CI, 1.24–2.12) of having multiple partners, even after adjusting for incarceration and age. Non-Hispanic white females were more likely to have multiple partners than racial/ethnic minority females.

CONCLUSIONS:

Although rates decrease over time, prevalence of sex risk behaviors are much higher than the general population. Among males, racial/ethnic minorities were at particular risk. The challenge for pediatric health is to address how disproportionate confinement of racial/ethnic minority youth contributes to disparities in the HIV/AIDS epidemic.
E-cigarettes and National Adolescent Cigarette Use: 2004–2014
Authors: Dutra Lauren M. , Glantz Stanton A.
Published: January 2017

BACKGROUND:

E-cigarette use is rapidly increasing among adolescents in the United States, with some suggesting that e-cigarettes are the cause of declining youth cigarette smoking. We hypothesized that the decline in youth smoking changed after e-cigarettes arrived on the US market in 2007.

METHODS:

Data were collected by using cross-sectional, nationally representative school-based samples of sixth- through 12th-graders from 2004–2014 National Youth Tobacco Surveys (samples ranged from 16 614 in 2013 to 25 324 in 2004). Analyses were conducted by using interrupted time series of ever (≥1 puff) and current (last 30 days) cigarette smoking. Logistic regression was used to identify psychosocial risk factors associated with cigarette smoking in the 2004–2009 samples; this model was then applied to estimate the probability of cigarette smoking among cigarette smokers and e-cigarette users in the 2011–2014 samples.

RESULTS:

Youth cigarette smoking decreased linearly between 2004 and 2014 (P = .009 for ever smoking and P = .05 for current smoking), with no significant change in this trend after 2009 (P = .57 and .23). Based on the psychosocial model of smoking, including demographic characteristics, willingness to wear clothing with a tobacco logo, living with a smoker, likelihood of smoking in the next year, likelihood of smoking cigarettes from a friend, and use of tobacco products other than cigarettes or e-cigarettes, the model categorized <25% of current e-cigarette–only users (between 11.0% in 2012 and 23.1% in 2013) as current smokers.

CONCLUSIONS:

The introduction of e-cigarettes was not associated with a change in the linear decline in cigarette smoking among youth. E-cigarette–only users would be unlikely to have initiated tobacco product use with cigarettes.
Record of the Giant Otter, Pteronura brasiliensis (Zimmermann, 1780), (Carnivora: Mustelidae) in a fragmented landscape of Maranhão state, Brazil
Authors: Prist Paula Ribeiro , Dornas Rubem , Dos Santos Raphael Hipólito , Torres Leonardo Gabriel Campos , Lima Estevão Luis Pereira
Published: January 2017

Three individuals of the endangered Giant Otter (Pteronura brasiliensis) were sighted in a small river in the municipality of Buriticupu, Maranhão state, Brazil. Information on the distribution of this species is contradictory, with some authors ignoring while others confirming the presence of this species in this state, but only in the Rebio do Gurupi region. We document the presence of this species in Maranhão state, outside the Rebio do Gurupi area. Our record of P. brasiliensis expands the known regional distribution 290 km eastwards from the closest previously known occurrence.
Microstructure and physical properties of nano charcoal ash as binder
Authors: Jeffry Siti Nur Amiera , Putra Jaya Ramadhansyah , Abdul Hassan Norhidayah , Mirza Jahangir , Mohd Yusak Mohd Ibrahim
Published: January 2017

Waste coconut shell (CS) was used to produce nano charcoal ash (NCA) as a potential modifier material in an asphalt binder. This study focused on the microstructural and physical properties of NCA. Thermogravimetric analysis and derivative thermogravimetric analysis (TGA/DTA), field emission scanning electron microscopy (FESEM), X-ray fluorescence, particle size analysis (PSA), penetration tests, softening point tests and dynamic shear rheometer (DSR) tests were performed. The TGA/DTA results revealed 490°C to be a suitable CS burning temperature to form carbon and to reduce impurities. The morphology determined by FESEM showed that charcoal CS presents a smooth, porous and irregular shape. The carbon content on the surface of the material was 77·6%, as indicated by energy-dispersive X-ray spectroscopy. PSA showed that the optimum size of the charcoal CS obtained after several grinding cycles was 148 nm. Test results indicated that adding NCA from coconut shell to bitumen improved the binder stiffness up to 47% and significantly increased the softening point up to 12% compared with virgin binder. The DSR test revealed that the optimum size of NCA enhanced the bitumen by increasing the resistance to rutting until a temperature of 76°C was reached, prior to failure at a temperature of 82°C.