bluuebunny/crossref_metadata_2025 huggingface dataset:
Calcium Regulation on the Atrial Regional Difference of Collagen Production Activity in Atrial Fibrogenesis
Authors: Chung Cheng-Chih , Lin Yung-Kuo , Chen Yao-Chang , Kao Yu-Hsun , Yeh Yung-Hsin , Chen Yi-Jen
Published: June 2021

Background: Atrial fibrosis plays an important role in the genesis of heart failure and atrial fibrillation. The left atrium (LA) exhibits a higher level of fibrosis than the right atrium (RA) in heart failure and atrial arrhythmia. However, the mechanism for the high fibrogenic potential of the LA fibroblasts remains unclear. Calcium (Ca2+) signaling contributes to the pro-fibrotic activities of fibroblasts. This study investigated whether differences in Ca2+ homeostasis contribute to differential fibrogenesis in LA and RA fibroblasts. Methods: Ca2+ imaging, a patch clamp assay and Western blotting were performed in isolated rat LA and RA fibroblasts. Results: The LA fibroblasts exhibited a higher Ca2+ entry and gadolinium-sensitive current compared with the RA fibroblasts. The LA fibroblasts exhibited greater pro-collagen type I, type III, phosphorylated Ca2+/calmodulin-dependent protein kinase II (CaMKII), phosphorylated phospholipase C (PLC), stromal interaction molecule 1 (STIM1) and transient receptor potential canonical (TRPC) 3 protein expression compared with RA fibroblasts. In the presence of 1 mmol/L ethylene glycol tetra-acetic acid (EGTA, Ca2+ chelator), the LA fibroblasts had similar pro-collagen type I, type III and phosphorylated CaMKII expression compared with RA fibroblasts. Moreover, in the presence of KN93 (a CaMKII inhibitor, 10 μmol/L), the LA fibroblasts had similar pro-collagen type I and type III compared with RA fibroblasts. Conclusion: The discrepancy of phosphorylated PLC signaling and gadolinium-sensitive Ca2+ channels in LA and RA fibroblasts induces different levels of Ca2+ influx, phosphorylated CaMKII expression and collagen production.
Effects of Percutaneous Electrolysis on Endogenous Pain Modulation: A Randomized Controlled Trial Study Protocol
Authors: Varela-Rodríguez Sergio , Sánchez-González Juan Luis , Sánchez-Sánchez José Luis , Delicado-Miralles Miguel , Velasco Enrique , Fernández-de-las-Peñas César , Calderón-Díez Laura
Published: June 2021

Percutaneous electrolysis consists of the application of a galvanic electrical current throughout an acupuncture needle. It has been previously hypothesized that needling procedures’ neurophysiological effects may be related to endogenous pain modulation (EPM). This protocol study describes the design of a double-blind (participant, assessor) randomized controlled trial with the aim to investigate whether percutaneous electrolysis is able to enhance EPM and whether the effect is different between two applications depending on the dosage of the galvanic electrical current. Seventy-two asymptomatic subjects not reporting the presence of pain symptoms the previous 6 months before the study, aged 18–40 years, are randomized into one of four groups: a control group who does not receive any intervention, a needling group who receives a needling intervention without electrical current, a low-intensity percutaneous electrolysis group (0.3 mA × 90 s), and a high-intensity percutaneous electrolysis group (three bouts of 3 mA × 3 s). Needling intervention consists of ultrasound-guided insertion of the needle on the common extensor tendon of the lateral epicondyle. The primary outcome is conditioned pain modulation (CPM), and secondary outcomes include widespread pressure pain sensitivity (pressure pain thresholds (PPT) over the lateral epicondyle, the cervical spine, and the tibialis anterior muscle) and temporal summation (TS). We expected that percutaneous electrolysis would have a greater influence on CPM than an isolated needling procedure and no intervention. In addition, we also postulated that there might be differences in outcome measures depending on the intensity of the electrical current during the percutaneous electrolysis application. This study makes a new contribution to the field of neurophysiological effects of percutaneous electrolysis and needling interventions.
Epithelial–Mesenchymal Transition Associated with Head and Neck Squamous Cell Carcinomas: A Review
Authors: González-González Rogelio , Ortiz-Sarabia Gamaliel , Molina-Frechero Nelly , Salas-Pacheco José Manuel , Salas-Pacheco Sergio Manuel , Lavalle-Carrasco Jesús , López-Verdín Sandra , Tremillo-Maldonado Omar , Bologna-Molina Ronell
Published: June 2021

Head and neck squamous cell carcinomas (HNSCCs) are aggressive, recurrent, and metastatic neoplasms with a high occurrence around the world and can lead to death when not treated appropriately. Several molecules and signaling pathways are involved in the malignant conversion process. Epithelial–mesenchymal transition (EMT) has been described in HNSCCs, a major type of aggressive carcinoma. EMT describes the development of epithelial cells into mesenchymal cells, which depends on several molecular interactions and signaling pathways that facilitate mesenchymal conversion. This is related to interactions with the microenvironment of the tumor, hypoxia, growth factors, matrix metalloproteinases, and the presence of viral infections. In this review, we focus on the main molecules related to EMT, their interactions with the tumor microenvironment, plasticity phenomena, epigenetic regulation, hypoxia, inflammation, their relationship with immune cells, and the inhibition of EMT in the context of HNSCCs.
Co-Deregulated miRNA Signatures in Childhood Central Nervous System Tumors: In Search for Common Tumor miRNA-Related Mechanics
Authors: Lambrou George I. , Zaravinos Apostolos , Braoudaki Maria
Published: June 2021

Despite extensive experimentation on pediatric tumors of the central nervous system (CNS), related to both prognosis, diagnosis and treatment, the understanding of pathogenesis and etiology of the disease remains scarce. MicroRNAs are known to be involved in CNS tumor oncogenesis. We hypothesized that CNS tumors possess commonly deregulated miRNAs across different CNS tumor types. Aim: The current study aims to reveal the co-deregulated miRNAs across different types of pediatric CNS tumors. Materials: A total of 439 CNS tumor samples were collected from both in-house microarray experiments as well as data available in public databases. Diagnoses included medulloblastoma, astrocytoma, ependydoma, cortical dysplasia, glioblastoma, ATRT, germinoma, teratoma, yoc sac tumors, ocular tumors and retinoblastoma. Results: We found miRNAs that were globally up- or down-regulated in the majority of the CNS tumor samples. MiR-376B and miR-372 were co-upregulated, whereas miR-149, miR-214, miR-574, miR-595 and miR-765 among others, were co-downregulated across all CNS tumors. Receiver-operator curve analysis showed that miR-149, miR-214, miR-574, miR-595 and miR765 could distinguish between CNS tumors and normal brain tissue. Conclusions: Our approach could prove significant in the search for global miRNA targets for tumor diagnosis and therapy. To the best of our knowledge, there are no previous reports concerning the present approach.
Unbalance in Iron Metabolism in Childhood Leukemia Converges with Treatment Intensity: Biochemical and Clinical Analysis
Authors: Łęcka Monika , Słomka Artur , Albrecht Katarzyna , Żekanowska Ewa , Romiszewski Michał , Styczyński Jan
Published: June 2021

Objective: The aim of this study was to evaluate non-transferrin-bound iron (NTBI) and labile plasma iron (LPI) levels and other parameters of iron metabolism in children undergoing therapy for acute leukemia or after hematopoietic cell transplantation (HCT), in the context of iron overload. Patients: A total number of 85 children were prospectively included into four groups: controls, acute leukemia de novo, acute leukemia after intensive treatment, and after HCT. Methods: The following iron metabolism parameters were analyzed: (1) parameters measuring functional and storage iron pools: NTBI, LPI, iron, transferrin, total iron-binding capacity, ferritin, ferritin heavy and light chains; (2) proteins regulating iron absorption and its release from tissue stores: hepcidin, soluble hemojuvelin, soluble ferroportin-1; (3) proteins regulating the erythropoietic activity of bone marrow: erythroferrone, erythropoietin, soluble transferrin receptor. Results: Intensive treatment of leukemia in children was associated with the presence of serum NTBI and LPI, which was the highest in the HCT group followed by the acute leukemia after treatment and de novo groups. In patients after HCT, the most significant changes were found in NTBI, LPI, iron, ferritin, hepcidin, and ferroportin-1 levels. Conclusions: The occurrence of NTBI and LPI in the circulation and the intensification of disturbances in iron metabolism were associated with the intensity of the anti-leukemic treatment.
Soluble Programmed Death Ligand-1 (sPD-L1): A Pool of Circulating Proteins Implicated in Health and Diseases
Authors: Bailly Christian , Thuru Xavier , Quesnel Bruno
Published: June 2021

Upon T-cell receptor stimulation, the Programmed cell Death-1 receptor (PD-1) expressed on T-cells can interact with its ligand PD-L1 expressed at the surface of cancer cells or antigen-presenting cells. Monoclonal antibodies targeting PD-1 or PD-L1 are routinely used for the treatment of cancers, but their clinical efficacy varies largely across the variety of tumor types. A part of the variability is linked to the existence of several forms of PD-L1, either expressed on the plasma membrane (mPD-L1), at the surface of secreted cellular exosomes (exoPD-L1), in cell nuclei (nPD-L1), or as a circulating, soluble protein (sPD-L1). Here, we have reviewed the different origins and roles of sPD-L1 in humans to highlight the biochemical and functional heterogeneity of the soluble protein. sPD-L1 isoforms can be generated essentially by two non-exclusive processes: (i) proteolysis of m/exoPD-L1 by metalloproteases, such as metalloproteinases (MMP) and A disintegrin and metalloproteases (ADAM), which are capable of shedding membrane PD-L1 to release an active soluble form, and (ii) the alternative splicing of PD-L1 pre-mRNA, leading in some cases to the release of sPD-L1 protein isoforms lacking the transmembrane domain. The expression and secretion of sPD-L1 have been observed in a large variety of pathologies, well beyond cancer, notably in different pulmonary diseases, chronic inflammatory and autoimmune disorders, and viral diseases. The expression and role of sPD-L1 during pregnancy are also evoked. The structural heterogeneity of sPD-L1 proteins, and associated functional/cellular plurality, should be kept in mind when considering sPD-L1 as a biomarker or as a drug target. The membrane, exosomal and soluble forms of PD-L1 are all integral parts of the highly dynamic PD-1/PD-L1 signaling pathway, essential for immune-tolerance or immune-escape.
Inhibition of CDK4/6 as Therapeutic Approach for Ovarian Cancer Patients: Current Evidences and Future Perspectives
Authors: Dall’Acqua Alessandra , Bartoletti Michele , Masoudi-Khoram Nastaran , Sorio Roberto , Puglisi Fabio , Belletti Barbara , Baldassarre Gustavo
Published: June 2021

Alterations in components of the cell-cycle machinery are present in essentially all tumor types. In particular, molecular alterations resulting in dysregulation of the G1 to S phase transition have been observed in almost all human tumors, including ovarian cancer. These alterations have been identified as potential therapeutic targets in several cancer types, thereby stimulating the development of small molecule inhibitors of the cyclin dependent kinases. Among these, CDK4 and CDK6 inhibitors confirmed in clinical trials that CDKs might indeed represent valid therapeutic targets in, at least some, types of cancer. CDK4 and CDK6 inhibitors are now used in clinic for the treatment of patients with estrogen receptor positive metastatic breast cancer and their clinical use is being tested in many other cancer types, alone or in combination with other agents. Here, we review the role of CDK4 and CDK6 complexes in ovarian cancer and propose the possible use of their inhibitors in the treatment of ovarian cancer patients with different types and stages of disease.
n-Butene Synthesis in the Dimethyl Ether-to-Olefin Reaction over Zeolites
Authors: Hanaoka Toshiaki , Aoyagi Masaru , Edashige Yusuke
Published: June 2021

Zeolite catalysts that could allow the efficient synthesis of n-butene, such as 1-butene, trans-2-butene, and cis-2-butene, in the dimethyl ether (DME)-to-olefin (DTO) reaction were investigated using a fixed-bed flow reactor. The zeolites were characterized by N2 adsorption and desorption, X-ray diffraction (XRD), thermogravimetry (TG), and NH3 temperature-programmed desorption (NH3-TPD). A screening of ten available zeolites indicated that the ferrierite zeolite with NH4+ as the cation showed the highest n-butene yield. The effect of the temperature of calcination as a pretreatment method on the catalytic performance was studied using three zeolites with suitable topologies. The calcination temperature significantly affected DME conversion and n-butene yield. The ferrierite zeolite showed the highest n-butene yield at a calcination temperature of 773 K. Multiple regression analysis was performed to determine the correlation between the six values obtained using N2 adsorption/desorption and NH3-TPD analyses, and the n-butene yield. The contribution rate of the strong acid site alone as an explanatory variable was 69.9%; however, the addition of micropore volume was statistically appropriate, leading to an increase in the contribution rate to 76.1%. Insights into the mechanism of n-butene synthesis in the DTO reaction were obtained using these parameters.
Cancer Stem Cells: What Do We Know about Them?
Authors: Skvortsova Ira
Published: June 2021

During past decades, survival rates in cancer patients have drastically improved due to the successful development of novel, promising chemical compounds and therapeutic schedules [...]
Osteoimmuno-Oncology: Therapeutic Opportunities for Targeting Immune Cells in Bone Metastasis
Authors: Kähkönen Tiina E. , Halleen Jussi M. , Bernoulli Jenni
Published: June 2021

Immunotherapies provide a potential treatment option for currently incurable bone metastases. Bone marrow is an important secondary lymphoid organ with a unique immune contexture. Even at non-disease state immune cells and bone cells interact with each other, bone cells supporting the development of immune cells and immune cells regulating bone turnover. In cancer, tumor cells interfere with this homeostatic process starting from formation of pre-metastatic niche and later supporting growth of bone metastases. In this review, we introduce a novel concept osteoimmuno-oncology (OIO), which refers to interactions between bone, immune and tumor cells in bone metastatic microenvironment. We also discuss therapeutic opportunities of targeting immune cells in bone metastases, and associated efficacy and safety concerns.
Sensing Atrazine Herbicide Degradation Products through Their Interactions with Humic Substances by Surface-Enhanced Raman Scattering
Authors: Zanasi Giulia , Rubira Rafael J. G. , Francioso Ornella , Cañamares Maria Vega , Constantino Carlos J. L. , Sanchez-Cortes Santiago
Published: June 2021

In this work, we have developed a simple method to carry out the quantitative analysis of deethylhydroxyatrazine (DEHA), the most abundant metabolite of atrazine herbicide (ATZ), based on the surface-enhanced Raman scattering technique. Since this ATZ product can undergo pH-dependent tautomerization, a previous characterization of the DEHA vibrational spectrum was accomplished. This study consisted of the Raman scattering study, both experimental and theoretical, of the enolic and ketonic tautomers of this molecule. SERS spectra were recorded at different pH in order to assess the effect of the metal surface in nanoparticles along with the pH on the structure of DEHA and to find the optimal experimental conditions of the quantitative detection of DEHA. Additionally, the interaction of DEHA with two types of humic acid reference standards, the Elliot humic and leonardite humic ones, was also performed by SERS. This interaction was conducted with two different objectives: to evaluate the interaction mechanism of the ATZ degradation product with humic substances and to check if this interaction can modify the sensitivity of the SERS detection of DEHA. The results presented in this study have clearly demonstrated that SERS spectroscopy is a very powerful technique for characterizing DEHA and other triazine sub-products at a very low concentration in water and also for analyzing the interaction of these important pollutants with humic substances.
Decline in Motor Function during the COVID-19 Pandemic Restrictions and Its Recovery in a Child with Cerebral Palsy: A Case Report
Authors: Asano Daiki , Kikuchi Naoko , Yamakawa Toru , Morioka Shu
Published: June 2021

Children with cerebral palsy (CP) experience various restrictions owing to their underdeveloped mobility. Home confinement due to the coronavirus disease 2019 pandemic may further increase these restrictions. We report the case of a 7-year-old boy with CP (Gross Motor Function Classification System level IV) whose motor function declined during the period when physical therapy was discontinued due to lockdown, approximately four months. At the end of the home confinement, the patient’s ability to maintain a sitting posture and weight-bearing capacity of the lower extremities decreased. His Gross Motor Function Measure total score also decreased from 34.5% to 31.9%. After resuming physical therapy, the patient recovered the function status seen before the discontinuation of physical therapy, but this took almost twice as long as the confinement period. We reaffirm that frequent physical therapy is crucial for maintaining motor function in non-ambulatory children with CP. As a countermeasure for the future, urgent efforts are needed for the development of telerehabilitation.
Ice Coverage Induced by Depositing a Water Drop onto the Supercooled Substrate at Extreme Low Vapor Pressure
Authors: Zhao Yugang , Zuo Zichao , Tang Haibo , Zhang Xin
Published: June 2021

Icing/snowing/frosting is ubiquitous in nature and industrial processes, and the accretion of ice mostly leads to catastrophic consequences. The existing understanding of icing is still limited, particularly for aircraft icing, where direct observation of the freezing dynamics is inaccessible. In this work, we investigate experimentally the impact and freezing of a water drop onto the supercooled substrate at extremely low vapor pressure, to mimic an aircraft passing through clouds at a relatively high altitude, engendering icing upon collisions with pendant drops. Special attention is focused on the ice coverage induced by an impinging drop, from the perimeter pointing outward along the radial direction. We observed two freezing regimes: (I) spread-recoil-freeze at the substrate temperature of Ts = −15.4 ± 0.2 °C and (II) spread (incomplete)-freeze at the substrate temperature of Ts = −22.1 ± 0.2 °C. The ice coverage is approximately one order of magnitude larger than the frozen drop itself, and counterintuitively, larger supercooling yields smaller ice coverage in the range of interest. We attribute the variation of ice coverage to the kinetics of vapor diffusion in the two regimes. This fundamental understanding benefits the design of new anti-icing technologies for aircraft.
Interactions of Ruddlesden-Popper Phases and Migration-Induced Field-Stabilized Polar Phase in Strontium Titanate
Authors: Ludt Christian , Ovchinnikova Elena , Kulikov Anton , Novikov Dmitri , Gemming Sibylle , Meyer Dirk C. , Zschornak Matthias
Published: June 2021

This work focuses on the validation of a possible connection of the known Ruddlesden-Popper (RP) phases and the novel concept of the migration-induced field-stabilized polar (MFP) phase. To study this subject, model structures of RP phases in bulk strontium titanate are analyzed by means of density functional theory (DFT). The obtained geometries are compared to experimental MFP data. Good agreement can be found concerning atomic displacements in the pm range and lattice strain inferred by the RP phases. Looking at the energy point of view, the defect structures are on the convex hull of the Gibb’s free energy. Although the dynamics to form the discussed defect models are not addressed in detail, the interplay and stability of the described defect model will add to the possible structure scenarios within the near-surface region of strontium titanate. As a result, it can be suggested that RP phases generally favor the MFP formation.
Design Strategy for Recycled Aggregate Concrete: A Review of Status and Future Perspectives
Authors: Makul Natt , Fediuk Roman , Amran Mugahed , Zeyad Abdullah M. , Klyuev Sergey , Chulkova Irina , Ozbakkaloglu Togay , Vatin Nikolai , Karelina Maria , Azevedo Afonso
Published: June 2021

Currently, a number of disadvantages hampers the use of recycled concrete aggregates (RCA). The current review proves that concretes made with complete replacement of natural aggregate with RCA allow the production of high-quality concrete. One of the possibilities for improving concrete properties with RCA is the use of extended curing and pozzolanic materials with varying cement ratios. The potential use of RCA concretes is in the production of high-value materials that increase environmental and financial benefits. RCA have strong potential in the development of a new generation of concrete and stimulate economic activity in many countries in addition to optimizing natural resources. Economic benefits include minimal travel costs; cheaper sources of concrete than newly mined aggregates; reduction of the landfill area required for the placement of concrete waste; the use of RCA minimizes the need for gravel extraction, etc. The proposed strategy could be to sequentially separate demolition waste such as roof finishes, waterproof materials, interior and exterior materials, etc. Closing life cycles is the main approach used for efficient structures for the recycling and reuse of construction and demolition waste in the production and recovery of materials, especially when recycling and reusing materials. In the life cycle, the recycling of recovered materials allows them to be used for new construction purposes, avoiding the use of natural concrete aggregates. Government, design institutes, construction departments and project managers should be involved in the creation and use of RCA. In demolition and construction, the main players are the project owners. Their obligations, expectations and responsibilities must be properly aligned. For the past 20 years, recycled concrete aggregate from demolition and construction waste has been considered as an alternative to pure concrete in structural concrete to minimize the environmental impact of construction waste and demolition waste and the conversion of natural aggregate resources. It is now recognized that the use of RCA for the generations of concrete is a promising and very attractive technology for reducing the environmental impact of the construction sector and conserving natural resources. In the market, the selling price is not an obstacle for market applications of RCA, as there are scenarios in which their cost is lower than the cost of products made from conventional building materials. This is more of an acceptance factor in the market for recycled concrete aggregates. In this sector, the lack of identification, accreditation and uniform quality certification systems and their narrow application cause some marketing problems. With proper RCA preparation, concrete with standard physical and mechanical properties and performance characteristics can be obtained.
The Feasibility and Effects of a Telehealth-Delivered Home-Based Prehabilitation Program for Cancer Patients during the Pandemic
Authors: Wu Fiona , Rotimi Oloruntobi , Laza-Cagigas Roberto , Rampal Tarannum
Published: June 2021

Patients awaiting cancer treatment were classified as “vulnerable” and advised to shield to protect themselves from exposure to coronavirus during the pandemic. These measures can negatively impact patients. We sought to establish the feasibility and effects of a telehealth-delivered home-based prehabilitation program during the pandemic. Eligible patients were referred from multiple centers to a regional prehabilitation unit providing home-based prehabilitation. The enrolled patients received telehealth-delivered prehabilitation prior to surgery and/or during non-surgical cancer treatment, which included personalized training exercises, dietary advice, medical optimization therapies, and psychological support. The primary outcome was to investigate the feasibility of our program. The secondary outcome was to investigate the relationship between our program and patient-reported outcomes (PROs). The patients completed two questionnaires (the EQ-5D-3L and the FACIT-Fatigue Scale) pre- and post-intervention. A total of 182 patients were referred during the study period. Among the 139 (76%) patients that were enrolled, 100 patients completed the program, 24 patients have still to complete, and 15 have discontinued. A total of 66 patients were able to return completed questionnaires. These patients were recruited from colorectal, urology, breast, and cardiothoracic centers. The patients significantly improved their self-perceived health (p = 0.001), and fatigue (p = 0.000). Home-based prehabilitation is a feasible intervention. The PROs improved post-intervention.
Genetic, but Not Behavioral, Evidence Supports the Distinctiveness of the Mealy Amazon Parrot in the Brazilian Atlantic Forest
Authors: Hellmich Dominique L. , Saidenberg Andre B. S. , Wright Timothy F.
Published: June 2021

The presence of unidentified cryptic species within a species complex can obscure demographic trends of vulnerable species, impacting potential species conservation and management decisions. Previous work identified a taxonomic split between Central and South American populations of the mealy amazon (Amazona farinosa) that subsequently resulted in the elevation of these two populations to full species status (Amazona guatemalae and A. farinosa, respectively). In that study, however, a third, geographically disjunct population from the Brazilian Atlantic Forest was insufficiently sampled, limiting the ability of researchers to fully evaluate its genetic distinctiveness. Given that significant levels of biodiversity and endemism are found in this region, we aimed to use genetic and behavioral data to determine if the Atlantic Forest population of A. f. farinosa represents a third cryptic species within the complex. We sequenced 6 genes (4 mitochondrial and 2 nuclear introns) from the Atlantic Forest population of A. f. farinosa to measure the genetic relationships between this population and all other recognized species and subspecies of the mealy amazon. In addition, we use spectrographic cross-correlation and an analysis of 29 acoustic parameters to determine whether the taxa diverge in their learned contact call structure and if the degree of vocal differentiation correlates to genetic structure. We found that the Atlantic Forest population of A. f. farinosa was genetically distinct from that of the greater Amazon basin, but the degree of differentiation was less than that separating the Central and South American taxa. Acoustic analysis revealed substantial variation in contact call structure within each clade. This variation created substantial overlap in acoustic space between the clades. In all, the degree of call divergence between clades did not correspond to the degree of genetic divergence between the same clades. The results suggest that in taxa with substantial geographic variation in learned calls, such as the mealy amazon, vocalizations may not be a useful tool in the identification of cryptic species that are lifelong vocal learners. While these results do not support the elevation of the Brazilian Atlantic Forest population of the mealy amazon to full species status, given current trends of habitat loss in the Atlantic Forest as well as the imperiled status of large parrot species globally, we argue that this population nonetheless warrants special conservation and management consideration as a pool of unique genetic diversity within the southern mealy amazon species.
Unfolding Jellyfish Bloom Dynamics along the Mediterranean Basin by Transnational Citizen Science Initiatives
Authors: Marambio Macarena , Canepa Antonio , Lòpez Laura , Gauci Aldo Adam , Gueroun Sonia K. M. , Zampardi Serena , Boero Ferdinando , Yahia Ons Kéfi-Daly , Yahia Mohamed Nejib Daly , Fuentes Verónica , Piraino Stefano , Deidun Alan
Published: June 2021

Science is addressing global societal challenges, and due to limitations in research financing, scientists are turning to the public at large to jointly tackle specific environmental issues. Citizens are therefore increasingly involved in monitoring programs, appointed as citizen scientists with potential to delivering key data at near to no cost to address environmental challenges, therein fostering scientific knowledge and advising policy- and decision-makers. One of the first and most successful examples of marine citizen science in the Mediterranean is represented by the integrative and collaborative implementation of several jellyfish-spotting campaigns in Italy, Spain, Malta, and Tunisia starting in 2009. Altogether, in terms of time coverage, geographic extent, and number of citizen records, these represent the most effective marine citizen science campaigns thus far implemented in the Mediterranean Sea. Here, we analyzed a collective database merging records over the above four countries, featuring more than 100,000 records containing almost 25,000 observations of jellyfish specimens collected over a period of 3 to 7 years (from 2009 to 2015) by citizen scientists participating in any of the national citizen science programs included in this analysis. Such a wide citizen science exercise demonstrates a valuable and cost-effective tool to understanding ecological drivers of jellyfish proliferation over the Western and Central Mediterranean basins, as well as a powerful contribution to developing tailored adaptation and management strategies; mitigating jellyfish impacts on human activities in coastal zones; and supporting implementation of marine spatial planning, Blue Growth, and conservation strategies.
Sustainability of Urbanization, Non-Agricultural Output and Air Pollution in the World’s Top 20 Polluting Countries
Authors: Das Ramesh Chandra , Chatterjee Tonmoy , Ivaldi Enrico
Published: June 2021

Rapid urbanization is being increasingly recognized as a significant factor of environmental pollution across the world. However, the significance of sustainable urbanization in controlling both pollution and population remains either limited in scope, in the case of developed countries, or less researched, in the case of developing nations. To fill this gap, the present study employed both theoretical and empirical tools to investigate the significant link between sustainable urbanization, pollution and non-agricultural output. In order to empirically examine the supposed link among the key variables mentioned above, the present study considered a panel of the world’s top 20 polluting countries for the 1991–2018 period, which significantly includes both developed and developing nations. Panel vector error correction model and panel co-integration techniques were employed to derive the possible correlation between the variables through sustainable urbanization. Empirical findings show an absence of equilibrium relations among the three variables in the panel of developed countries. However, the study clearly finds that all the three indicators maintain long-run associations for the panel of developing countries. Furthermore, in the short run, the results determine unambiguously that there are significant causal interplays between any two sets of variables and the remaining one variable for both the panel data of developed and developing countries. On the other hand, short-run interplays among the variables we considered exist for both developed and developing economies. From the perspective of policy formulation, the present study shows that policy makers from both the developed and developing nations should be cautious before encouraging urbanization, at least in the short term. However, the combined effects in the short and long term suggest policy makers should be more careful before encouraging urbanization in developing economies.
A Novel Mathematical Model Considering Real Gas PVT Behavior to Estimate Inflow Performance Relationship of Gas Well Production
Authors: Zhang Shuang , Liu Huiqing , Wang Yanwei , Sun Ke , Guo Yunfei
Published: June 2021

Inflow performance relationship (IPR) is one of the most important methods for the analysis of the dynamic characteristics of gas reservoir production. The objective of this study was to develop a model to improve the accuracy of the IPR for evaluating and predicting the production of gas reservoirs. In this paper, a novel mathematical model, taking into account the real gas PVT behavior, is developed to accurately estimate the inflow performance relationship. By introducing a pseudo-pressure function and a real gas properties database, this model eliminates the error caused by the linearization method and improves the calculation accuracy. The results show that more than 90% of the energy in the flow field is consumed by inertial forces, which leads to significant high-velocity non-Darcy effects in the gas reservoir. The reservoir permeability, original reservoir pressure, stress sensitivity coefficient, and skin factor have a great impact on the inflow performance relationship of gas reservoir production. This model predicts gas IPR curves with excellent accuracy and high efficiency. The high-precision gas well inflow performance relationship lays a solid foundation for dynamic production analysis, rational proration, and intelligent development of the gas field.
Branched Electron-Donor Core Effect in D-π-A Star-Shaped Small Molecules on Their Properties and Performance in Single-Component and Bulk-Heterojunction Organic Solar Cells †
Authors: Solodukhin Alexander N. , Luponosov Yuriy N. , Mannanov Artur L. , Savchenko Petr S. , Bakirov Artem V. , Shcherbina Maxim A. , Chvalun Sergei N. , Paraschuk Dmitry Yu. , Ponomarenko Sergey A.
Published: June 2021

Star-shaped donor-acceptor molecules are full of promise for organic photovoltaics and electronics. However, the effect of the branching core on physicochemical properties, charge transport and photovoltaic performance of such donor-acceptor materials in single-component (SC) and bulk heterojunction (BHJ) organic solar cells has not been thoroughly addressed. This work shows the comprehensive investigation of six star-shaped donor-acceptor molecules with terminal hexyldicyanovinyl blocks linked through 2,2′-bithiophene π-conjugated bridge to different electron-donating cores such as the pristine and fused triphenylamine, tris(2-methoxyphenyl)amine, carbazole- and benzotriindole-based units. Variation of the branching core strongly impacts on such important properties as the solubility, highest occupied molecular orbital energy, optical absorption, phase behavior, molecular packing and also on the charge-carrier mobility. The performance of SC or BHJ organic solar cells are comprehensively studied and compared. The results obtained provide insight on how to predict and fine-tune photovoltaic performance as well as properties of donor-acceptor star-shaped molecules for organic solar cells.
Dynamic Loads and Response of a Spar Buoy Wind Turbine with Pitch-Controlled Rotating Blades: An Experimental Study
Authors: Russo Sara , Contestabile Pasquale , Bardazzi Andrea , Leone Elisa , Iglesias Gregorio , Tomasicchio Giuseppe R. , Vicinanza Diego
Published: June 2021

New large-scale laboratory data are presented on a physical model of a spar buoy wind turbine with angular motion of control surfaces implemented (pitch control). The peculiarity of this type of rotating blade represents an essential aspect when studying floating offshore wind structures. Experiments were designed specifically to compare different operational environmental conditions in terms of wave steepness and wind speed. Results discussed here were derived from an analysis of only a part of the whole dataset. Consistent with recent small-scale experiments, data clearly show that the waves contributed to most of the model motions and mooring loads. A significant nonlinear behavior for sway, roll and yaw has been detected, whereas an increase in the wave period makes the wind speed less influential for surge, heave and pitch. In general, as the steepness increases, the oscillations decrease. However, higher wind speed does not mean greater platform motions. Data also indicate a significant role of the blade rotation in the turbine thrust, nacelle dynamic forces and power in six degrees of freedom. Certain pairs of wind speed-wave steepness are particularly unfavorable, since the first harmonic of the rotor (coupled to the first wave harmonic) causes the thrust force to be larger than that in more energetic sea states. The experiments suggest that the inclusion of pitch-controlled, variable-speed blades in physical (and numerical) tests on such types of structures is crucial, highlighting the importance of pitch motion as an important design factor.
Ignition Studies on High-Vitrinite and High-Inertinite Coals Using TGA/DSC, DTIF, EFR, and 20 L Dust Explosive Chamber
Authors: Rybak Wiesław , Moroń Wojciech , Wach Janusz
Published: June 2021

The aim of this work was to study the ignition behaviour of eight coals of different coal ranks, petrographic compositions, and places of origin. The research allows us to gain deeper insight into the ignition mechanism and the relationship between certain properties of coals and their behaviour during ignition. The methodology utilised standard fuel ASTM data, petrographic analysis, pyrolysis and oxidation reactivity, and ignition characteristics generated through lab-scale tests using various ignition measurement methods. The results show that, in the dust explosion, a homogeneous ignition of coal dust took place. The ignition potential was the highest for coals with a high content of liptinites and a low content of inertinites. The ranking of coals in terms of ignition potential under these conditions can be determined on the basis of the measurements of the devolatilization rate. During the combustion of coal dust in TGA/DSC, a dust cloud, and a pulverised fuel stream, the ignition of particles was performed according to a heterogeneous mechanism. The study showed that the reflectance index may be the most reliable method of predicting and comparing ignition temperatures of both vitrinite-rich and inertinite-rich coals. Due to the lack of regularity in the ignition temperatures of some coals, depending on the proportion of inertinites, the petrographic composition of coal cannot be used to predict ignition temperatures during the combustion of coal dust. The ranking of the coals according to their ignition potential can be determined using TGA/DSC.
Improved Virtual Inertia of PMSG-Based Wind Turbines Based on Multi-Objective Model-Predictive Control
Authors: Qin Shiyao , Chang Yuyang , Xie Zhen , Li Shaolin
Published: June 2021

In the case of a high penetration rate of wind energy conversion systems, the conventional virtual inertia control of permanent magnet synchronous generators (PMSG) has an insufficient support capability for system frequency, leading to an unstable system frequency and a slower response. Considering the finite control set model predictive control has multi-objective regulation capabilities and efficient tracking capabilities, and an improved multi-objective model-predictive control is proposed in this paper for PMSG-based wind turbines with virtual inertia based on its mathematical model. With the prediction model, the optimal control of the current and the frequency of the PMSG-based wind turbines can be obtained. Since the shaft torque changes rapidly under high virtual inertia, shaft oscillation may occur under this scenario. To address this problem, the electromagnetic torque is set as an additional optimization objective, which effectively suppresses the oscillation. Furthermore, based on accurate short-term wind speed forecasting, a dynamic weight coefficient strategy is proposed, which can reasonably distribute the weight coefficients according to the working conditions. Finally, simulations are carried out on a 2 MW PMSG-based wind turbine platform, and the effectiveness of the proposed control strategies is verified.
Current and Predicted Future Winter Warm Spells Would Affect Douglas Fir (Pseudotsuga menziesii (Mirb.), Franco) Seeds in the Early Stage of Germination More Than in the Late Stage of Germination
Authors: Jastrzębowski Szymon , Ukalska Joanna , Guziejko Adam , Puchałka Radosław
Published: June 2021

Most tree species in the temperate climatic zone (including Douglas fir) disperse seeds in autumn. Some of them must be exposed to cold (0–10 °C) and moist conditions (cold stratification) to overcome dormancy and trigger germination. In the Northern Hemisphere, winter warm spells occur more frequently and last longer than in recent decades from eastern Canada to Europe. Our main research objective was to investigate the influence of current (1 or 3 days at day/night temperatures: 15 °C/10 °C) and future predicted (5 days at day/night temperatures: 25 °C/15 °C) winter warm spells on dormancy breaking and germination traits (germination energy—GE; germination capacity—GC; final germination capacity—FGC) of Douglas fir seeds from four old-growth stands in northern Poland. For this purpose, we interrupted cold stratification of seeds at different time points, i.e., after 3 weeks; 6 weeks; 9 or 3 weeks and 6 weeks; 3 and 9 weeks; 6 and 9 weeks; 3 and 6 weeks and 9 weeks. We found that for GE and GC, all main effects (populations—P; days of warm spell—D; stratification duration—W) and interactions were significant (except interaction P×D). FGC was significantly affected by the effects P and D and interactions of D × W and P × D × W. In addition, we found that the predicted warm spells negatively affected the early germination stage (GE and GC) of Douglas fir, but both current and future predicted winter conditions will not negatively affect the late germination stage (FGC).
Landscape-Scale Drivers of Resistance and Resilience to Bark Beetles: A Conceptual Susceptibility Model
Authors: Windmuller-Campione Marcella A. , DeRose Justin , Long James N.
Published: June 2021

Bark beetle (Dendroctonus spp.) outbreaks in the middle latitudes of western North America cause large amounts of tree mortality, outstripping wildfire by an order of magnitude. While temperatures play an important, and direct role in the population dynamics of ectothermic bark beetles, an equally important influence is the nature of the host substrate—the structure and composition of forested communities. For many of the dominant tree species in the western United States, “hazard” indices have been developed for specific bark beetles, which generally include three key variables—host tree size, absolute or relative density of the stand, and percentage of host composition. We provide a conceptual model to apply these three variables across forest ecosystems and bark beetles that shifts the thinking from a species–specific model to a model which focuses on the underlying ecological factors related to bark beetle outbreak susceptibility. We explored the use of our model across multiple scales using the Forest Inventory and Analysis database: Interior West, USA; the states of Colorado and Arizona; and specific national forests within Arizona that are implementing a large-scale restoration effort. We demonstrated that across the Interior West and Colorado, the vast majority of forests have moderate to high susceptibility to bark beetles. Our conceptual model maintains the simplicity of previous “hazard” models but acknowledges the need to consider scale when managing bark beetles. It also shifts the management approach from resistance thinking to the development of “associational resilience”, where the focus is not on any one individual stand or area but the longer-term perspective of forest persistence across the landscape.
Data in Context: How Digital Transformation Can Support Human Reasoning in Cyber-Physical Production Systems
Authors: Müller Romy , Kessler Franziska , Humphrey David W. , Rahm Julian
Published: June 2021

In traditional production plants, current technologies do not provide sufficient context to support information integration and interpretation. Digital transformation technologies have the potential to support contextualization, but it is unclear how this can be achieved. The present article presents a selection of the psychological literature in four areas relevant to contextualization: information sampling, information integration, categorization, and causal reasoning. Characteristic biases and limitations of human information processing are discussed. Based on this literature, we derive functional requirements for digital transformation technologies, focusing on the cognitive activities they should support. We then present a selection of technologies that have the potential to foster contextualization. These technologies enable the modelling of system relations, the integration of data from different sources, and the connection of the present situation with historical data. We illustrate how these technologies can support contextual reasoning, and highlight challenges that should be addressed when designing human–machine cooperation in cyber-physical production systems.
Text Analysis Methods for Misinformation–Related Research on Finnish Language Twitter
Authors: Jussila Jari , Suominen Anu Helena , Partanen Atte , Honkanen Tapani
Published: June 2021

The dissemination of disinformation and fabricated content on social media is growing. Yet little is known of what the functional Twitter data analysis methods are for languages (such as Finnish) that include word formation with endings and word stems together with derivation and compounding. Furthermore, there is a need to understand which themes linked with misinformation—and the concepts related to it—manifest in different countries and language areas in Twitter discourse. To address this issue, this study explores misinformation and its related concepts: disinformation, fake news, and propaganda in Finnish language tweets. We utilized (1) word cloud clustering, (2) topic modeling, and (3) word count analysis and clustering to detect and analyze misinformation-related concepts and themes connected to those concepts in Finnish language Twitter discussions. Our results are two-fold: (1) those concerning the functional data analysis methods and (2) those about the themes connected in discourse to the misinformation-related concepts. We noticed that each utilized method individually has critical limitations, especially all the automated analysis methods processing for the Finnish language, yet when combined they bring value to the analysis. Moreover, we discovered that politics, both internal and external, are prominent in the Twitter discussions in connection with misinformation and its related concepts of disinformation, fake news, and propaganda.