bluuebunny/crossref_metadata_2025 huggingface dataset:
Vector Autoregressive Model Using Non-Normal Copula Errors
Authors: - Beulah S William , - Nimitha John
Published: May 2024

This article focuses on a bivariate vector autoregressive model of lag 1 with non-normal errors. We propose a
bivariate error distribution using two identical marginals through a copula function. The copula used for the study
is the Farlie-Gumbel-Morgenstern copula, which is considered to be one of the efficient class of copula in describing
the dependence between two random variables. The model parameters are estimated using the method of inference
functions for margins, and the finite sample properties of the model is illustrated through simulation studies.
A real life example is considered to illustrate the applications of the proposed model. The adequacy of the copula
model is examined using the two sample version of kolmogorov smirnov test statistic.
Exploring Emotional Intelligence and Workplace Environment Among Women Employees
Authors: - Amandeep Gill , - Ashish Mathur , - Shailendra Singh Bhadouria
Published: May 2024

This study explores the relationship between emotional intelligence (EI) and the workplace environment among female employees. The research investigates emotional intelligence levels and their impact on workplace relationships. The study employs a cross-sectional survey design to collect data from female employees, focusing on self-awareness, self-regulation, motivation, empathy, and social skills. A sample of 99 women employees participated in the survey. Data analysis includes descriptive analysis, reliability analysis, chi-square tests of independence, cluster analysis, linear regression, and factor analysis. Results indicate significant associations between emotional intelligence levels and workplace ratings. K-means clustering identifies three clusters based on emotional intelligence and workplace ratings, reflecting different levels of emotional intelligence and corresponding workplace ratings. However, linear regression analysis suggests that emotional intelligence does not significantly predict workplace ratings. Factor analysis reveals that while a single factor might explain a portion of the variance in emotional intelligence, there may be other factors at play as well, possibly two. These findings provide insights into the complex relationship between emotional intelligence and the workplace environment among female employees, emphasizing the need for further research to fully understand the underlying dynamics.
The Impact of Social Media Advertising on Consumer Purchase Decisions
Authors: - Chandrashekhar kashyap , - Nirbhay Yadav , - Chirag Tabhane , - Sourav Kumar Singh , - Shriyansh singh
Published: May 2024

Social media has risen as an effective stage for promoting, impacting shopper behaviors and buying choices universally. This considers points to investigate the effect of social media publicizing on customer buy choices, analyzing the components through which social media campaigns influence buyer inclinations, demeanors, and eventually, buying behavior. The investigation utilizes a mixed-methods approach, combining quantitative investigation of buyer studies with subjective examination of social media advertisement substance and engagement measurements. Key components such as advertisement significance, validity, personalization, and social impact are explored to get their part in forming customer discernments and choices. Discoveries uncover that compelling social media promotion altogether impacts buyer buy choices by making mindfulness, improving brand engagement, building belief, and leveraging social supports. Besides, the study reveals the significance of focused on publicizing techniques, intuitive substance, and consumer-generated input in driving positive customer reactions and cultivating brand devotion. The suggestions of these discoveries amplify to marketers, sponsors, and businesses looking for to optimize their social media promoting techniques to viably reach and lock in their target group of onlookers, improve brand discernment, and drive change rates. Future investigate headings are proposed to dig deeper into particular industry settings, buyer sections, and developing social media patterns to improve our understanding of the energetic exchange between social media promotion and customer behavior.
A Comparative Study of Mental Health of Female Adolescents with Social Networking Addiction Status
Authors: - POOJA MALLICK , - KUMKUM PAREEK
Published: May 2024

The aim of the present study was to estimate the impact of social networking addiction status on the mental health of female adolescents. For this purpose, the sample consists of 70 female subjects of age 15 to 20 years. There was one independent variable that varied at two levels i.e., addicted in SNAS (social networking addiction scale) and non-addicted in SNAS (social networking addiction scale). The dependent variable is mental health. The mental health was measured by mental health scale. This scale was constructed and standardized by Dr. Kamlesh Sharma. Obtained data were analyzed by using the Mean value, S.D. value and t-test.
Strategic Selection of Machine Learning Models for Short-term Trading Optimization
Authors: - Suman Halder , - Debjyoti Bagchi , - Anirban Samanta , - Debarghya Mondal , - Subhradeep Samanta , - Shreya Hati , - Abhishek Kundu
Published: May 2024

Stock market prediction is a key aspect for a financial analyst and investor, as it facilitates better decisions and improved investment strategies. Towards this end, this project compares how machine learning (ML) models perform in predicting stock market prices with relatively small dataset sizes so as to get the best performing one. This study evaluates the efficiency and accuracy of artificial neural networks, support vector regression, LSTM and decision trees in capturing market trends and forecasting stock movements. The importance of our proposed paper lies in its potential to demystify the complexities of financial markets for students and new entrants in the field of finance. Participants can garner practical insights on how the stock market operates and the application of theoretical ML concepts to financial analytics by identifying the best-performing ML models with limited datasets, which is a common occurrence in real-life situations. This paper aims to analyse the commonly present machine learning models in stock market prediction and choose the most effective model depending upon their performance, which is achieved using limited information (short term data). This would provide an edge in taking small (less-risky) informed financial decisions without extensive study of the stock market.
Exploring the Influence of Emotional Competence on Humor Styles and Personality Traits
Authors: - Shreya Sharma , - Meenakshi Singh
Published: May 2024

This research aims to uncover the complexities of the dynamics that regulate human behavior and connection with others by investigating the relationships between humor styles, emotional competence, and personality factors. Using a wide range of literature review and empirical research, this study examines how individuals' humor styles, defined by their tendency to affiliate, self-enhance, be aggressive, or dislike themselves, interact with emotional competence and personality characteristics. As a transdisciplinary construct, humor provides various psychological functions and shapes people's emotional experiences and social relationships. The affiliative style, which uses humor to strengthen social ties and relieve tension, has been linked to increased emotional intelligence and extraversion. Conversely, aggressive humor, which includes sarcasm and derision, is associated with weaker emotional competence and greater degrees of neuroticism. Emotional competence, which provides for emotional awareness, management, and expression, is critical in balancing the impacts of various humor styles on psychological well-being and interpersonal interactions. Individuals with greater emotional competence prefer to use adaptive humor styles, which promote good emotions and social cohesiveness. In contrast, individuals with lower emotional competence may use maladaptive methods, such as self-defeating humor, as a coping strategy. Furthermore, psychological qualities like extraversion, neuroticism, and openness to experience influence people's humor preferences and usage habits. Extraverts, for example, are likelier to engage in affiliative humor, whereas neurotic persons may use self-defeating humor as a defense strategy. This study adds to a better understanding of human behavior by illuminating the interaction between humor styles, emotional competence, and personality factors. It also gives insights into how to promote psychological well-being and efficient interpersonal communication.”
Women as an Active Agent of Food Security-Issues and Challenges
Authors: - Surabi Dutta
Published: May 2024

Achieving food security and eliminating hunger and poverty within 2030 as aimed in Sustainable Development Goals(SDGs) necessitates the active role of women, which constitutes 48.41% (Census,2022) of the total population of India. The role of this active agent of society is undermined by prevailing gender discrimination and inequalities. In this backdrop, the present study is designed as follows-
Purpose: (i) To analyse the critical role of women in achieving food security
(ii) To identify the constraints of gender equality and
(iii) To generate priority interventions for gender equality and women
empowerment.
Methodology: In this secondary analysis of cross-sectional data, we used data from different international and national reports like NFHS, Agricultural Census Reports, reports of FAO and UNDP etc. The critical role of women is analysed with the help of available descriptive statistics.
Results: The existing 16.3% of undernourished people in India (Global Food Insecurity Index,2022) invariably necessitates empowering women with equal rights and opportunities as men. There is a need for proactive interventions to minimize the 48% empowerment deficit (Women Empowerment Index) and 44% (GGPI) gender gap in the country.
Limitations: The women groups considered in different research and reports vary in age groups, which limits the comparison of data.
Originality: The constraints women face in attaining food security are based on their functions as producers, consumers and distributors of the food chain, expected to provide a basis for further research in this regard.
The Evolution and Impact of Online Payment Systems on E-commerce
Authors: - Nikhil Kashyap , - Nitesh Rohilla , - Suraj Das
Published: May 2024

Digital Transactions - Investigating the Advancement and Affect of Online Installment Frameworks in E-commerce The appearance of computerized exchanges has revolutionized the scene of e-commerce, changing the way businesses and buyers lock in budgetary exchanges. This ponders digs into the advancement and affect of online installment frameworks on e-commerce, pointing to get it the key mechanical progressions, appropriation patterns, and the coming about suggestions for businesses and customers. The investigation utilizes a mixed-methods approach, combining subjective examination of chronicled information on online installment frameworks with quantitative examination of buyer selection rates and inclinations. Key variables such as security measures, comfort highlights, integration with e-commerce stages, and administrative systems are investigated to illustrate their part in forming the advancement of online installment frameworks. Discoveries uncover a critical advancement in online installment frameworks, from conventional strategies like credit/debit cards to more up-to-date advances such as versatile wallets, advanced monetary standards, and peer-to-peer installment stages. The think about moreover reveals the affect of these headways on customer behavior, highlighting expanded belief, comfort, and speed of exchange as key drivers of selection. In addition, the study looks at the suggestions of online installment frameworks on e-commerce businesses, counting diminished cart surrender rates, improved client encounters, and extended advertise reach. Challenges such as cybersecurity dangers, installment preparing expenses, and administrative compliance are too talked about within the setting of their affect on e-commerce operations. The suggestions of these discoveries extend to e-commerce businesses, monetary teaching, policymakers, and customers. Techniques for optimizing online installment frameworks to meet advancing shopper desires, upgrade exchange security, and cultivate advanced inclusivity are proposed. Moreover, future research headings are proposed to dig deeper into developing innovations and regulatory systems forming the long-term of advanced exchanges in e-commerce.
Harnessing AI, IoT and Quantum Resonance Magnetic Analysis for Digital Diagnosis and Treatment
Authors: - Soyel Akter Habib , - Md Maruf Billah , - Marrimanu Hasif basha , - Vipul Kumar
Published: May 2024

This research presents the development and implementation of a novel healthcare ecosystem leveraging Internet of Things (IoT), Artificial Intelligence (AI), Deep Learning and Quantum Magnetic Resonance Analysis (QMRA) technology. The aim is to streamline medical diagnostics and treatment processes by integrating a hardware device capable of conducting comprehensive body scans in minutes, coupled with an Android application for data collection and presentation. The hardware device utilizes Quantum Magnetic Resonance Analyzer for rapid and accurate body scanning, enabling users to record symptoms through voice clips and capture images of wounds or other concerns. The collected data is securely transmitted to a backend database hosted on Firebase for storage and retrieval. The Android app facilitates seamless access to patient profiles by registered doctors, empowering them to analyze scan reports, review recorded symptoms, and view images for informed diagnosis and treatment planning. By combining IoT, AI, and Quantum Magnetic Resonance Analysis, this healthcare ecosystem offers a transformative approach to medical care, improving efficiency, accessibility, and accuracy in diagnosis and treatment.
Mainstreaming Slow Pace Learners Through Mobile Assisted Language Learning: A Case of Bengali Primary Level Students with Dyslexia
Authors: - Md. Sahajalal Badsha
Published: May 2024

Every child has the right of taking education. The rights of having education of the children who have learning disabilities come forward in recent decades. The main aim of this thesis was to explore how Mobile assisted language learning tools can help the dyslexic children in mainstreaming education. Towards attaining the broad objectives, the study has also focused on some relevant objectives such as, to assist students with dyslexia in mainstreaming by focusing on phonological, morphological, and syntactical awareness, introducing dyslexic students to a multi-sensory learning system, to propose a focused device to assist dyslexic students in dealing with phoneme-grapheme harmonization, which are crucial in reading, to identify the perceptions about dyslexia among parents and teachers. Qualitative study was applied for this study where five dyslexic students were played main role as sample. Moreover, four teachers and five parents have also a role of assisting sample. The study was conducted from a Government Primary School in Dhaka, Bangladesh. The study showed that children having dyslexia have more difficulties in reading the voiced sounds, multisyllabic words, rhyming sentences. Furthermore, they have problems of sentence repetition, naming and timing knowledge. The study also demonstrated that parents and teachers play very negative role with these children that causes them to demotivate in terms of going school regularly. The major findings of the study showed that mobile assisted language learning tools help these dyslexic students to develop their skills in a tremendous way. The main reason is that they can hear a sound or word as many times possible as they want compared to the classroom where they have not the opportunity to ask several times. After using the tools, they felt more motivated and encouraged and most importantly they started enjoying their learning. Though government and many organizations have taken many activities to promote mainstreaming education, the opportunity of mainstreaming the dyslexic students is yet to develop.
Domain Specific Named Entity Recognition Using Natural Language Processing (NLP) and Software Engineering in Production World
Authors: - Bickey Kumar Shah , - Prince Kumar
Published: May 2024

This research is concerned with domain-specific named entity recognition in which certain keywords are withdrawn from the phrase and sentences of the words or paragraph. The project in hand has been effective in different sectors like the insurance companies and hospitals for withdrawing the required keywords in a small amount of time. For instance, a medicine that belongs to a specific keyword is extracted easily and the same occurs with necessary keywords in the case of insurance companies. Advancements in deep neural networks have been established to build the named entity recognition model (NER Model). We have used Spacy and natural language processing for keyword extraction. The future scope of the project is to use LSTM for domain-specific keyword extraction and transfer learning using NLP. A large dataset is required to build the system for keyword extraction since dataset have always been the challenging part of such a system.
Interaksi Dinamis Sitoskeleton dengan Membran Sel
Authors: Rahmadina Rahmadina , Abdullah Ahmad , Khairani Aulia A'yun , Nisa Dea Fahrum , Ruwaida Salma , Rosa Siti , Harahap Uswatun Hasanah
Published: May 2024

Interaksi dinamis antara sitoskeleton dan membran sel adalah fenomena kompleks yang memainkan peran penting dalam hal biologi seluler. Pada penelitian ini, metode kualitatif dengan pendekatan studi pustaka digunakan untuk mengeksplorasi dan menyusun penjelasan komprehensif tentang interaksi sitoskeleton dengan membran sel melalui analisis literatur ilmiah yang relevan. Tinjauan literatur tentang struktur dan fungsi sitoskeleton membantu memahami peran utama komponen sitoskeleton dalam pembentukan kerangka sel dan interaksi dengan membran sel. Analisis artikel penelitian dan tinjauan literatur terkait yang mengungkapkan bagaimana sitoskeleton dan membran sel berinteraksi dalam berbagai proses seluler dan regulasi oleh sinyal intraseluler. Implikasi klinis dari temuan penelitian dan tantangan yang dihadapi dalam penelitian interaksi ini juga dibahas yaitu mengenai pentingnya kolaborasi antar disiplin ilmu, evaluasi metode penelitian, dan penyebaran informasi yang luas juga ditekankan. Kesimpulannya, pemahaman yang mendalam tentang interaksi dinamis sitoskeleton dengan membran sel memiliki potensi besar untuk pengembangan terapi baru dan teknologi medis yang lebih efektif dalam bidang biomedis.
Estrategias para fomentar la equidad e inclusión en las escuelas. Estudio documental
Authors: Mounkoro Ismaila
Published: May 2024

Este artículo se enfocó en realizar un análisis documental sobre la educación inclusiva, identificando las ideas clave y más significativas que resaltan la presencia de la diversidad en el ámbito educativo. Se destacó la importancia de recabar información sobre métodos pedagógicos que permitan a los educadores adaptarse a los cambios hacia una educación más inclusiva. Se llegó a la conclusión de que es imprescindible para los docentes desarrollar estrategias que promuevan valores de inclusión educativa. En este sentido, la postura y el comportamiento del docente dentro del aula juegan un papel crucial en el éxito de este proceso inclusivo, el cual está marcado por una diversidad de creencias y emociones, algunas de las cuales pueden ser favorables y otras no.
Prevalence of Obesity with its Associated Modifiable Risk Factors among Adolescents of Aged 17-24 Years: Cross-Sectional Study
Authors: Zaib Shah , Raza Tahira , Ahmad Afnan , Anwar Shahzaib , Haroon Tariq Syed Muhammad , Mubashar Tahir
Published: May 2024

Objective: This study aims to point out the association of modifiable risk factors and the prevalence and riskfactors of overweight and obesity among adolescents aged 17-24 years.Study Design: Cross-sectional descriptive study.Place and Duration of Study: The study was conducted at the Department of Community Medicine, CombinedMilitary Hospital (CMH) College Lahore, Pakistan from April 2022 to May 2022.Methods: A cross-sectional study was performed on a sample size of 108 adult males through nonprobabilityconvenient sampling in CMH Lahore Medical College, Lahore, Pakistan. HbA1c tests were conducted to checkblood sugar. A questionnaire was distributed to collect data. SPSS software was used for the analysis of datausing the Chi-square test.Results: A total of 108 male cadets participated in the study. Mean age was 20.20 years ±1.4 SD. The majority ofparticipants were involved in physical activity and had healthy eating habits. Eighty-nine percent ofrespondents fall in the category of normal body mass index & 6.5% in the category of overweight & obese & 3.7% were underweight. Forty-seven percent of subjects were physically active for ≤ 3 days/week & 57.4% wereengaged for > 3 days/week. Fifty-seven percent of respondents had a screen time of 5-7 hours/day & 11.1% has> 7 hours/day. Among 108 respondents, 37% had snacking habits in between meals 1-2 times/week & 20.4%has 3-4 times/week.Conclusion: This study concludes that apart from non-modifiable risk factors, modifiable risk factors also have a major influence on the prevalence of overweight & obesity. Those who exercise & eat healthy have less risk ofdeveloping obesity as compared to those who have poor physical activity & unhealthy eating habits.
How to cite this: Zaib S, Raza T, Ahmad A, Anwar S, Tariq SMH, Mubashar T. Prevalence of Obesity with its Associated Modifiable Risk Factors Among Adolescents of Aged 17-24 Years: Cross Sectional Study. Life and Science. 2024; 5(2): 210-215. doi: http://doi.org/10.37185/LnS.1.1.362
Quantifying Renal Changes: A Study of Area of Bowman's Space Following Prolonged Itopride Hydrochloride Exposure in Albino Rats
Authors: Hashmi Aasma , Syed Hamd , Irfan Ayesha , Rabbani Ali , Mir Amaidah
Published: May 2024

Objective: To see the effects of long-term administration of itopride hydrochloride on the histomorphology of kidney of the male Wistar albino rats.Study Design: A Laboratory based experimental study.Place and Duration of Study: The study was conducted at the Department of Anatomy, CMH Multan Institute of Medical Sciences Multan, Pakistan from September 2020 to March 2022.Methods: The study involved two groups: Group A served as the control, and Group B functioned as the experimental group. Each group consisted of 30 adult male albino rats. The animals of group A were administered 2ml/100g of distilled water by oral gavage along with a diet for laboratory rodents daily for 15 days. The animals of group B were given 4.4mg/kg of itopride hydrochloride dissolved in 2ml/100g body weight of distilled water by oral gavage three times a day for 15 days. The kidney was processed for paraffin embedding and stained with Periodic Acid Schiff (PAS). The area of Bowman's space was measured by linear micrometer after calibration with a stage micrometer and image J software. The student's t-test was utilized to assess potential differences between the two groups, with significance set at a p-value of ≤ 0.05.Result: The area of Bowman's space was significantly increased in the experimental group as compared to the control group (p= 0.045).Conclusion: Long-term Itopride Hydrochloride administration appears to influence the area of Bowman's Space in Wistar albino rats.
How to cite this: Hashmi A, Syed H, Irfan A, Rabbani A, Mir A, Razzaq M. Quantifying Renal Changes: A Study of Area of Bowman's Space Following Prolonged Itopride Hydrochloride Exposure in Albino Rats. Life and Science. 2024; 5(2): 138-143. doi: http://doi.org/10.37185/LnS.1.1.539
Prevention of Uterine Inversion by Using Ultrasonographic Confirmation During Placental Delivery in Dr. Ruth K.M Pfau Civil Hospital Karachi
Authors: Shahid Abbasi Tahmina , Kubra Kaneez , Zarrar Tabassum , Tasneem Maria , Gul Pashmina
Published: May 2024

Objective: To determine the prevention of uterine inversion by using ultrasonographic confirmation duringplacental delivery.Study Design: Cross-sectional study.Place and Duration of Study: The study was carried out at the Department of Gynecology Unit II, Dr. Ruth K.MPfau Civil Hospital Karachi, Pakistan from June 2022 to June 2023.Methods: In this research, the total of 180 patients were included with transvaginal deliveries. To preventuterine inversion during placental delivery, regular ultrasonographic was implemented. The placental deliverywas performed with ultrasonographic confirmed placental detachment. The frequency of uterine inversionduring placental delivery was compared before and after the introduction of ultrasonographic images. Inaddition, a comparison was made between the ultrasonographic group and the non-ultrasonographic groupregarding the amount of blood loss during transvaginal delivery and the length of the third stage of labor. TheDescriptive statistics were applied to all parameters Using SPSS Version 26.Results: A total of 180 patients who had transvaginal deliveries, mean age 29 ± 9 years. One hundred and eighty women had transvaginal deliveries before and after the introduction of ultrasonography. Following theultrasonographic confirmation, there was a significant decrease in the frequency of uterine inversion whencompared to the pre-introduction period (43.3% vs. 56.7%, p = 0.001). Due to a number of limitations, theactual rate of ultrasonography performed even after it was introduced ultrasonography was 46.1%.Conclusion: In our investigation, we concluded that with the help of ultrasonographic confirmation of placentaldetachment uterine inversion may be prevented.
How to cite this: Abbasi TS, Kubra K, Zarrar T, Tasneem M, Gul P. Prevention of Uterine Inversion by Using Ultrasonographic Confirmation During Placental Delivery in Dr. Ruth K.M Pfau Civil Hospital Karachi. Life and Science. 2024; 5(2): 204-209. doi: http://doi.org/10.37185/LnS.1.1.563
Hepatoprotective Effect of Aqueous Neem Leaves Extract on Hepatocytes and Nuclear Diameter of Albino Wistar Rats Induced with Erythromycin Toxicity
Authors: Jamshed Nausheen , Raza Iffat , Razzaq Mehwish , Jamshed Naureen , Rasheed Aaqiba , Faisal Lubna
Published: May 2024

Objective: To evaluate the hepatoprotective effects of Neem leaves extract on hepatocyte and nucleardiameters of Albino Wistar rats induced by erythromycin hepatotoxicity.Study Design: Laboratory-based Experimental study.Place and Duration of Study: The study was carried out at the Department of Anatomy and Animal House ofBaqai Medical University (BMU) in Karachi, Pakistan from January 2019 to March 2019.Methods: A total of 80 Albino Wistar rats were divided equally into 4 groups. The control group was markedas Group A with no interventions. In Group B only erythromycin was administered. For Group C botherythromycin and aqueous Neem leave Extract were given and for Group D only aqueous neem leave wasgiven. Animals were sacrificed and the liver weight of Albino Wistar rats was measured.Results: It was observed that rats of experimental control group A noticed no significant change inhepatocytes13.19± 0.44μm and nuclear diameters 7.18±0. 28μm (Figure.1) as this group had no interventionreceived. In group B hepatocyte diameter markedly increased by 16.54±0.6μm and a decrease in nucleardiameter of 5.20±0.30μm (p<0.01) with loss of architecture, ballooning, and edematous changes (Figure.2, 3and 4) was observed as this group received only erythromycin while group C received both erythromycin andaqueous Neem leaf extract showed histological architecture disrupted to some extent and hepatocytes14.49±80μm and nuclear diameter 6.13±0.17μm were started to improve its normal sizes (Figure.5). Group Dobserved no significant changes in hepatocytes 13.0±0.52μm and nuclear diameters 7.14±0.30μm as thisgroup only received aqueous neem leave extract (Figure.6).Conclusion: According to the current study, Erythromycin exerts oxidative stress and Changes in hepatocytesand nuclear diameters were noticeably improved by aqueous neem leaf extract, which is a powerfulantioxidant.
How to cite this: Jamshed N, Raza I, Razzaq M, Jamshed N, Rasheed A, Faisal L. Hepatoprotective Effect of Aqueous Neem Leaves Extract on Hepatocytes and Nuclear Diameter of Albino Wistar Rats Induced with Erythromycin Toxicity. Life and Science. 2024; 5(2): 228-236. doi: http://doi.org/10.37185/LnS.1.1.572
Comparison of Efficacy of Ciprofloxacin and Co-Trimoxazole in Escherichia Coli Urinary Tract Infection
Authors: Ayaz Muhammad , Zeeshan Kausar Sayed Ali , Alamgir Muhammad , Muhammad Shafiq , Muhammad Khan Fayaz , Ullah Sami
Published: May 2024

Objective: To compare the efficacy of ciprofloxacin and co-trimoxazole in urinary tract infection due to Escherichia Coli.Study Design: A cross- sectional study. Place and Duration of Study: This study was conducted at the Department of Medicine, Muhammad TeachingHospital (MTH), Peshawar, Pakistan from 1 July 2022 to 31 December 2022.Methods: Patients were randomly and consecutively assigned to either group by using lottery method (double blind). A total of 194 patients diagnosed with urinary tract infection due to E coli were randomly divided into two groups, 97 patients in each group, using 54% efficacy of ciprofloxacin, 74% efficacy of Co-Trimoxazole, 95% confidence level, and 90% power of test, using WHO software. “Group-A' for Ciprofloxacin 500mg BD and th 'Group-B' for Co-Trimoxazole 960mg BD. All the recruited patients were followed up after the 48 hour of their treatment and results were recorded. The chi-Square test was applied to compare the efficacy results of both drugs where a PValue < 0.05 was considered as significant value.Results: The mean age of group A participants were 48.4 + 11.1 years, whereas, in group B it was 48.2 + 11.5 years. There were 69.1% males and 30.9% females in group A compared to 80.4% males and 19.6% females ingroup B. After the 48 hour of end treatment, efficacy was 79.3% and 50.5%, in groups A and B respectively (p-value = 0.000).Conclusion: As compared to Cotrimoxazole, Ciprofloxacin is more effective in treating E. coli-caused urinary tract infections.
How to cite this: Ayaz M, Kausar SAZ, Alamgir M, Muhammad S, Khan FM, Ullah S. Comparison of Efficacy of Ciprofloxacin and CoTrimoxazole in Escherichia Coli Urinary Tract Infection. Life and Science. 2024; 5(2): 151-159. doi: http://doi.org/10.37185/LnS.1.1.595
The Effectiveness and Safety of Fenofibrate and Saroglitazar in the Treatment of Diabetic Dyslipidemia
Authors: Farooq Bakhtawar , Cheema Rafay-Ur-Rehman , Qureshi Zahid Habib , Yasmeen Nabeela , Sahu Ejaz Hussain
Published: May 2024

Objective: This study aimed to evaluate the efficacy and safety of saroglitazar and fenofibrate in treatingdiabetic dyslipidemia.Study Design: Comparative cross-sectional study.Place and Duration of Study: The study was conducted at the Department of Biochemistry, Nishtar MedicalUniversity and Hospital Multan, Pakistan over 12 months from January 2021 to January 2022.Methods: Following a 4-week run-in phase, sixty newly diagnosed patients with a previous diagnosis ofdiabetes and dyslipidemia were included. Eligible participants were aged 18-65 years, with fasting triglyceride(TG) levels >200–400 mg/dL and documented type 2 diabetes mellitus (T2DM). Following baselineassessments, participants were randomised into two treatment groups: Saroglitazar 4 mg with 10 mg ofAtorvastatin and Fenofibrate 200 mg with 10 mg of Atorvastatin. Lipid profiles, fasting blood glucose (FBG), andHbA1c were evaluated at baseline and after 12 weeks. Statistical analysis was conducted using appropriatetests with p< 0.05, which is considered significant.Results: The study enrolled 60 participants, with comparable baseline characteristics between groups. Whileboth treatments showed similar effects on lipid profiles, Saroglitazar showed exceptional effectiveness inlowering HbA1c and FBG levels compared to Fenofibrate. No significant differences in adverse effects wereobserved.Conclusion: Saroglitazar may offer advantages in managing diabetic dyslipidemia and improving glycemiccontrol compared to Fenofibrate in a larger sample size. More investigation is necessary to confirm thesefindings and evaluate long-term safety and efficacy.
How to cite this: Farooq B, Cheema RR, Qureshi ZH, Yasmeen N, Sahu EH. The Effectiveness and Safety of Fenofibrate and Saroglitazar in The Treatment of Diabetic Dyslipidemia. Life and Science. 2024; 5(2): 266-272. doi: http://doi.org/10.37185/LnS.1.1.632
Impact of Short-Term Arsenic Exposure on Hormonal Balance and Fibrosis in Sprague Dawley Rats
Authors: Mir Amaidah , Mir Urfa Zaryab , Hussain Warda , Irfan Ayesha , Ahmed Butt Hammad , Sarwar Urwa
Published: May 2024

Objective: To evaluate the toxic effects of arsenic exposure on the female reproductive tract and endocrinesystem.Study Design: A laboratory-based experiment.Place and Duration of Study: The study was carried out at the Laboratory of the National Institute of Health(NIH) Islamabad, Pakistan from 1st January 2019 to 4th January 2020.Methods: non-probability convenient sampling technique was employed and 60 female healthy SpragueDawley rats were included in the study at the National Institute Islamabad. Animals were randomly allocatedinto control and experimental groups (n=30 each). In the first week, animals were acclimatized to the animalhouse of the College of Physicians and Surgeons Pakistan. In the second week, the control and experimentalgroups were given 10 ml of distilled water by oral gavage daily and 4μg of sodium arsenite dissolved in 10 ml ofdistilled water daily for two weeks respectively. After the experimental period, animals were taken to theanimal lab of the National Institute of Health Islamabad for blood sampling and tissue dissection. Rats wereeuthanized by chloroform inhalation and blood was drawn by single intracardiac puncture and stored in clotactivator vials at 4 0C for further workup. The female reproductive tract was dissected, and the tissue was stored in 10 % formalin for histological studies. Serum Gonadotropin-releasing hormone (GnRH) levels were assessed via the Enzyme-Linked Immunosorbent Assay (ELISA) method. Whereas histological effects of arsenic were observed under a microscope by tissue processing and staining with Masson trichrome stain. Mean ± SD of serum GnRH levels and percentage of fibrosis in uterine tissue of control and experimental groups wereevaluated by the software Statistical Package for Social Sciences version 22.0. Comparison of means evaluatedby Student T-test. The significant p-value was ≤ 0.05.Results: The experimental group showed significant elevation of serum GnRH levels and fibrotic changes withhigh collagen deposition (p ≤ 0.05).Conclusion: Exposure to arsenic via contaminated drinking water is disruptive for the female reproductive tractand endocrine system.
How to cite this: Mir A, Mir UZ, Hussain W, Irfan A, Butt HA, Sarwar U. Impact of Short-Term Arsenic Exposure on Hormonal Balance and Fibrosis in Sprague Dawley Rats. Life and Science. 2024; 5(2): 187-192. doi: http://doi.org/10.37185/LnS.1.1.64
LEGAL CHRONICLE
Authors:   HSE University, Ivanov Anton A. , Esakov Gennady A. , Glandin Sergey V. , Bando Mikhail V. ,   Ural State Law University,   Urals Branch of the Private Law Research Centre, Golovina Svetlana Yu. ,   Ural State Law University,   Ural Branch of the Private Law Research Centre
Published: May 2024

In the May Chronicle read comments on the adoption of the U.S. law on the confiscation of Russian assets, the decision of the Supreme Court of the Russian Federation on the issue of compensation for damage caused to the business reputation of a legal entity as a consequence of the commission of a crime, planned changes to the legislation on expanding the scope of information collected on Russian citizens in the unified federal register, on new labour law benefits for spouses of participants of the Special Military Operation and amendments to the Housing Code in order to implement the ruling of the Constitutional Court on the regulation of the provision of hotel services in the block of flats, as well as the rise of Internet censorship.
Compulsory Arbitration Clauses in International Disciplinary Sports Disputes: Features and Issues
Authors:   Institute of Legislation and Comparative Law under the Government of the Russian Federation, Voskoboynik Igor A.
Published: May 2024

Is international arbitration always consensual and based on the autonomy of will and free expression of the parties? The basic theory would undoubtedly answer this question affirmatively. However, in sports arbitration, things are somewhat more complex. Sports disputes can be broadly divided into two major groups: (1) commercial (transfers, sponsorship, contractual disputes with players, etc.) and (2) disciplinary (doping, violation of rules and statutes, failure to fulfill duties by both athletes and sports federations). In this sense, commercial sports disputes do not differ in any way, and they maintain a consensual element and the autonomy of the parties’ will. Meanwhile, the disciplinary sports disputes operate under a “mandatory arbitration model”, implying that without the consent of the parties, the Court of Arbitration for Sport in Lausanne (CAS) or internal bodies of sports federations, performing mandatory pre-judicial regulation, will be the only possible forums for resolving disputes with athletes. Is it right to permit the use of such a mechanism that clearly encroaches on personal autonomy? If so, should the coerced party be treated differently in any way? Why does CAS have exclusive jurisdiction over the majority of sports disputes, rather than, for example, the International Court of Arbitration of the International Chamber of Commerce (ICC)? This article will address all of the above questions.
Significance of Signature as a Requisite of Written Form
Authors:   HSE University, Dzhumagulov Daniil D.
Published: May 2024

The article is devoted to the study of the significance of signature as one of the requisites of written form of a transaction. The author examines the requirement for signature in Russia and foreign legal orders. On the basis of comparative experience he investigates the functions of the written form and handwritten signature. Based on the results of the study of three functions inherent in the handwritten signature: the function of determining the fact of the transaction, the function of confirming the seriousness of intentions and the evidentiary function, the author concludes that the performance of the transaction in a form that allows to reliably determine the person who expressed the will and to fix the written expression of will for a long period of time, fulfils the main functions of the handwritten signature. In conclusion, the author proposes to use a method that allows to determine the reliability of the expression of will, based on the use of a set of actions, as meeting the requirements of the three functions of a handwritten signature.
Legal Ways to Secure Subsoil Users’ Rights to Land: Problems of Modern Practice
Authors:   Ural State Law University, Shepeleva Natalia M.
Published: May 2024

The article analyses the regulation of the rights of subsoil users to use land plots, identifies problems arising from the seizure of land for the use of subsoil, and considers the prospects for improving legislation designed to ensure the subsoil user’s access to the corresponding land plot. It is noted that in practice there are unresolved issues related to the registration of land by subsoil users, compliance with the guarantees of the rights of other persons when granting or withdrawing land plots for state or municipal needs, in territorial planning. It is proposed to clarify the content of the rights of management bodies in the studied area, including in the implementation of territorial planning, taking into account the proposed subsoil use.
Production Sharing Agreements: A Difficult Fate in Russia
Authors:   GRK LLC, Sharifullina Aigul F.
Published: May 2024

The article provides a brief historical analysis of the conclusion and implementation of production sharing agreements (PSA) in the Russian Federation, stages of development of legislation in the field of PSA regulation. The author analyses changes in the legal regulation of PSA over the past two years, which led to changes in the composition of subjects and provisions of production sharing agreements in force in the Russian Federation. Based on the analysis conducted, conclusions are drawn about possible options for further development of the PSA institution in the Russian Federation, including the possibility of replacing PSA with a subsoil use regime on the basis of a license agreement in accordance with the Law of the Russian Federation “On Subsoil”.
Terapi Bermain Lego untuk Menurunkan Skala Kecemasan Hospitalisasi pada Anak dengan Neuroblastoma
Authors: Ramadhani Elfira Fajar , Punjastuti Budi , Yunitasari Pritta , Maryati Siti
Published: May 2024

Neuroblastoma merupakan salah satu jenis tumor padat perkembangan dari kanker pada sel saraf yang belum matang, biasanya muncul dari sel perkembangan sistem saraf simpatis. Terapi yg diberikan pada pasien dengan Neuroblastoma akan menyebabkan anak mengalami kecemasan hospitalisasi sehingga perlu diberikan terapi nonfarmakologis berupa bermain lego untuk menurunkan skala kecemasan. Menurut data rekam medis di RSUP DR Sardjito khususnya Bangsal Estella 2 periode Januari – Maret 2023 terdapat 6 anak. Penelitian ini bertujuan menerapkan terapi bermain lego untuk menurunkan skala kecemasan hospitalisasi pada anak dengan Neuroblastoma. Metode deskriptif untuk memperoleh gambaran dengan melakukan observasi serta menganalisis data yang akurat agar mudah dipahami. Setelah dilakukan terapi bermain lego pada anak usia prasekolah dengan Neuroblastoma di bangsal Estella 2 dengan frekuensi 1 kali sehari selama 3 hari didapatkan hasil kecemasan hospitalisasi pada pasien menurun dari skala 48 (kecemasan sedang) menjadi skala 20 (tidak ada kecemasan). Kesimpulan : didapatkan hasil penerapan terapi bermain lego untuk menurunkan kecemasan pada anak di Bangsal Estella 2 yang dilakukan selama 3 hari dengan durasi 45 menit dapat disimpulkan bahwa terapi bermain lego dapat menurunkan tingkat kecemasan hospitalisasi pada pasien anak dengan Neuroblastoma.
Dukungan Keluarga dan Pengaruh Dzikir dengan Kecemasan pada Ibu Hamil: Systematic Review
Authors: Handayani Rina Tri , Yuniarti Tri , Sunaryanti Sri Sayekti Heni , Nurhayati Isnani , Iswahyuni Sri , Anasulfalah Hakim , Widiyanto Aris , Atmojo Joko Tri
Published: May 2024

Rasa cemas adalah reaksi alami manusia terhadap stres, tetapi menjadi terlalu cemas dapat mengganggu kehidupan sehari-hari. Mereka yang mengalami kecemasan telah menemukan bahwa mendapatkan dukungan dari keluarga sangat membantu. Salah satu bentuk terapi spiritual yang dikenal sebagai terapi dzikir adalah dengan mengucapkan kalimat pujian kepada Allah SWT. Dipercaya bahwa metode ini dapat memberikan rasa tenang dan ketenangan batin, yang dapat membantu mengurangi kecemasan. Dukungan keluarga adalah sistem di mana anggota keluarga saling membantu, mendukung, dan mendukung satu sama lain dalam berbagai situasi.   Tujuan penelitian: Pengaruh dzikir dengan kecemasan dan dukungan keluarga dinilai. Metode: Penelitian ini merupakan ulasan sistematis dengan diagram PRISMA. Kriteria kelayakan Model PICO: P adalah pasien; I adalah dukungan keluarga dan dzikir; C adalah tidak dukungan keluarga dan tidak dzikir; dan O adalah tingkat kecemasan. Artikel yang digunakan berasal dari Google Scholar, sebuah database. Dengan kata kunci seperti "Dukungan keluarga", "kehamilan", "kecemasan", persalinan, dan dzikir. Hasil: Dalam delapan artikel, dukungan keluarga dan dzikir terkait dengan tingkat kecemasan. menunjukkan bahwa dukungan keluarga dan dzikir mengurangi kecemasan.
Pengaruh Pemberian Puding Jagung Kurma terhadap Kadar Hb pada Ibu Hamil Anemia
Authors: Apriliyanti Evie , Pangestu Gaidha Khusnul , Ginting Agus Santi Br , Ginting Agus Santi Br
Published: May 2024

Anemia pada ibu hamil menjadi isu serius karena berbagai dampaknya terhadap kesehatan ibu dan janin. Anemia pada ibu hamil disebut juga sebagai potential danger to mother and children karena dapat membahayakan ibu dan anaknya. Anemia pada ibu hamil sangat berpengaruh terhadap kualitas sumber daya manusia yang akan dilahirkan dan generasi yang akan datang. Penelitian ini bertujuan Untuk mengetahui pengaruh puding jagung kurma terhadap kadar HB pada ibu hamil anemia di PMB Evie Apriliyanti. Metode yang digunakan adalah metode kualitatif dan study case literatur review. Penelitian ini dilakukan di PMB Evie Apriliyanti pada bulan januari 2024. Populasi pada penelitian ini adalah ibu hamil yang berkunjung di PMB Evie Apriliyanti. Besar sampel yang dibutuhkan pada penelitian ini yaitu 2 ibu hamil yang mengalami masalah anemia ringan. Teknik sampling pada penelitian adalah purposive sampling. Adapun kriteria inklusi sampel adalah sebagai berikut Bersedia menjadi responden dan Ibu menderita anemia ringan (10,0-10,9 g/dl). Hasil penelitian ditemukan ada pengaruh pemberian tablet Fe dan puding jagung kurma terhadap kadar HB pada ibu hamil anemia di PMB Evie Apriliyanti dengan peningkatan Hb 0,6 gr/dl selama 7 hari pada ibu hamil. Ada pengaruh pemberian tablet Fe dan konseling terhadap kadar HB pada ibu hamil anemia di PMB Evie Apriliyanti dengan peningkatan Hb sebesar 0,2 gr/dl pada ibu hamil.
The Effects of General Anesthesia on Infants and Children's Later Development: A Comprehensive Systematic Review
Authors: Nugroho Rio Kristian , Lestari Sri
Published: May 2024

The relationship between pediatric neurodevelopment and general anesthesia has been the subject of numerous investigations, yet consensus remains elusive. Objective: This review aims to explore the connection between anesthesia and child development. We conducted a thorough search of Google Scholar, PubMed, and ProQuest databases from January 2000 until March 2024, using relevant search terms such as “Adolescent,” “Anesthesia, General/ adverse effects,” “Child,” “Child Development / drug effects,” and “Preschool” resulted in 40 out of 1572 studies for reviewed. The review focused on assessing the impact of general anesthesia on children's development, excluding studies involving children with significant comorbidities or lacking unexposed controls. Two coders independently evaluated the studies, adhering to Preferred Reporting Items for Systematic Reviews criteria. Our analysis of 40 primary studies unveiled a broad spectrum of outcomes regarding the impact of general anesthesia on infants and children's subsequent development. Across cognitive domains, anesthesia altered academic achievements, IQ, and language proficiency. Sensory responses were diverse, with anesthesia affecting manual dexterity, balance, and sensory performance uniquely. Psychosocially, it influenced behavior, social skills, and neuropsychological disorders, while neurodevelopmental concerns were also identified. In summary, the effects of general anesthesia on various developmental domains underscore the need for cautious consideration in medical practice. This review revealed cognitive decline, diverse sensory impacts, and increased behavioral issues, anxiety, and neurodevelopmental disorders associated with general anesthesia. Understanding these effects is crucial for implementing effective prevention and management strategies to mitigate long-term complications.