bluuebunny/crossref_metadata_2025 huggingface dataset:
Reduced T and NK Cell Activity in Glioblastoma Patients Correlates with TIM-3 and BAT3 Dysregulation
Authors: Ahmady Farah , Curpen Peter , Perriman Louis , Fonseca Teixeira Adilson , Wu Siqi , Zhu Hong-Jian , Poddar Arpita , Jayachandran Aparna , Kannourakis George , Luwor Rodney B.
Published: October 2024

Inhibitory receptors are critical for regulating immune cell function. In cancer, these receptors are often over-expressed on the cell surface of T and NK cells, leading to reduced anti-tumor activity. Here, through the analysis of 11 commonly studied checkpoint and inhibitory receptors, we discern that only HAVCR2 (TIM3) and ENTPD1 (CD39) display significantly greater gene expression in glioblastoma compared to normal brain and lower grade glioma. Cell surface TIM-3, but not ENTPD1, was also elevated on activated CD4+ and CD8+ T cells, as well as on NK cells from glioblastoma patients compared to healthy donor T and NK cells. A subsequent analysis of molecules known to co-ordinate TIM-3 function and regulation was performed, which revealed that BAT3 expression was significantly reduced in CD4+ and CD8+ T cells, as well as NK cells from glioblastoma patients compared to counterparts from healthy donors. These pro-inhibitory changes are also correlated with reduced levels of the activation marker CD69 and the pro-inflammatory cytokine IFNγ in CD4+ and CD8+ T cells, as well as NK cells from glioblastoma patients. Collectively, these data reveal that glioblastoma-mediated CD4+ and CD8+ T cell and NK cell suppression is due, at least in part, to dysregulated TIM-3 and BAT3 expression and the associated downstream immunoregulatory and dysfunctional effects.
High-Dose Chemotherapy and Autologous or Allogeneic Transplantation in Aggressive B-Cell Lymphoma—Is There Still a Role?
Authors: Daunov Michael , van Besien Koen
Published: October 2024

Novel therapies such as CAR-T, BTK inhibitors and PD-1 inhibitors have changed the management of aggressive B-cell lymphomas. Nonetheless, these novel therapies have their own risk of late toxicities including second malignancies. They also create a subgroup of patients with relapse, treatment failure, or indefinite maintenance. We discuss the current role of autologous and allogeneic stem cell transplantation in this context. In patients with recurrent diffuse large B-cell lymphoma, CAR-T cell treatment has largely replaced autologous transplant. Autologous transplant should be considered in patients with late relapses and in selected patients with T-cell-rich B-cell lymphoma, where CAR-T cell therapy may be less effective. It also remains the treatment of choice for consolidation of patients with primary CNS lymphoma. In mantle cell lymphoma, intensive chemotherapy combined with BTK inhibitors and rituximab results in excellent outcomes, and the role of autologous transplantation is declining. In Hodgkin’s lymphoma, autologous transplant consolidation remains the standard of care for patients who failed initial chemotherapy. Allogeneic transplantation has lower relapse rates but more complications and higher non-relapse mortality than autologous transplantation. It is usually reserved for patients who fail autologous transplantation or in whom autologous stem cells cannot be collected. It may also have an important role in patients who fail CAR-T therapies. The increasing complexity of care and evolving sequencing of therapies for patients with aggressive B-cell lymphomas only emphasizes the importance of appropriate patient selection and optimal timing of stem cell transplantation.
The TMEM63B Channel Facilitates Intestinal Motility and Enhances Proliferation of Intestinal Stem Cells
Authors: Tu Jing-Jing , Zang Yan-Yu , Shi Yun Stone , Teng Xiao-Yu
Published: October 2024

The intestines are in a constant state of motion and self-renewal. The mechanical breakdown of food facilitates intestinal movement and aids digestion. It is believed that mechanical stimulation, triggered by changes in osmotic pressure within the intestines, plays a crucial role in regulating gastrointestinal motility. While TRPs and PIEZO1/2 have been identified as mechanosensitive ion channels involved in this process, there still exist numerous unidentified channels with similar properties. In this study, we demonstrate that the TMEM63B expressed in intestinal stem cells contributes to the regulation of intestinal motility and digestion. The deletion of TMEM63B in intestinal stem cells not only decelerates intestinal motility and impairs digestion but also attenuates the proliferation of intestinal stem cells and exacerbates DSS-induced colitis in mice. Collectively, our findings unveil the pivotal role of TMEM63B in governing optimal digestive function and modulating intestinal motility.
Prognostic Indicators for Precision Treatment of Non-Small Cell Lung Carcinoma
Authors: Ghosh Damayanti Das , McDonald Hannah , Dutta Rajeswari , Krishnan Keerthana , Thilakan Jaya , Paul Manash K. , Arya Neha , Rao Mahadev , Rangnekar Vivek M.
Published: October 2024

Non-small cell lung cancer (NSCLC) has established predictive biomarkers that enable decisions on treatment regimens for many patients. However, resistance to therapy is widespread. It is therefore essential to have a panel of molecular biomarkers that may help overcome therapy resistance and prevent adverse effects of treatment. We performed in silico analysis of NSCLC prognostic indicators, separately for adenocarcinomas and squamous carcinomas, by using The Cancer Genome Atlas (TCGA) and non-TCGA data sources in cBioPortal as well as UALCAN. This review describes lung cancer biology, elaborating on the key genetic alterations and specific genes responsible for resistance to conventional treatments. Importantly, we examined the mechanisms associated with resistance to immune checkpoint inhibitors. Our analysis indicated that a robust prognostic biomarker was lacking for NSCLC, especially for squamous cell carcinomas. In this work, our screening uncovered previously unidentified prognostic gene expression indicators, namely, MYO1E, FAM83 homologs, and DKK1 for adenocarcinoma, and FGA and TRIB1 for squamous cell carcinoma. It was further observed that overexpression of these genes was associated with poor prognosis. Additionally, FAM83 homolog and TRIB1 unexpectedly harbored copy number amplifications. In conclusion, this study elucidated novel prognostic indicators for NSCLC that may serve as targets to overcome therapy resistance toward improved patient outcomes.
Investigating Leptin Gene Variants and Methylation Status in Relation to Breastfeeding and Preventing Obesity
Authors: Kilic Ayse , Pehlivan Sacide , Varkal Muhammet Ali , Tuncel Fatima Ceren , Kandemir Ibrahim , Ozcetin Mustafa , Poyrazoglu Sükran , Kardelen Asli Derya , Ozdemir Irem , Yildiz Ismail
Published: October 2024

Objective: We investigated whether the results of leptin gene (LEP) 2548G/A (rs7799039) and leptin receptor gene (LEPR) 668 A/G (rs1137101) variants, as well as the methylation analysis of CpG regions at nucleotides −31 and −51 of the LEP gene, showed any differences between breastfed and non-breastfed children in this study. Materials and Methods: The cross-sectional study included 100 children aged 2–5 years who were attending nursery and kindergarten and had been accepted to the Department of General Paediatrics. Infants who were exclusively breastfed for the first six months after birth constituted the study group, and those who were not only breastfeed constituted the control group. Methylation percentages at CpG islands of the LEP gene were compared between exclusively breastfed and non-exclusively breastfed infants, and the statistical significance was analyzed by looking for changes in LEP −31 and −51 nt methylation and LEP 2548G/A ve LEPR 668 A/G variants. Results: Both groups were compared by feeding, and the association of LEPR and LEP gene polymorphisms and −51 nt and −31 nt methylations were analyzed. There were no significant differences between the groups regarding genotype and allele frequency for the LEPR 668 A/G, LEP 2548 G/A gene variant, −31 nt methylation, and −51 nt methylation status. Similarly, there was no significant difference in genotype and allele frequency for the LEPR 668 A/G gene variant in terms of duration of exclusive breastfeeding, total breastfeeding, body mass index, family obesity, and satiety status. However, maternal support from family elders and physical activity increased the 51 nt methylation, but this methylation was not significantly affected by BMI, age, or satiety status. Conclusions: Maternal support from family elders and physical activity were associated with increased 51 nt methylation, but this methylation was not significantly affected by BMI, age, or satiety status. However, there are not enough studies in this area to reach a definitive conclusion, and further research is needed.
Digital Device Usage and Childhood Cognitive Development: Exploring Effects on Cognitive Abilities
Authors: Clemente-Suárez Vicente Javier , Beltrán-Velasco Ana Isabel , Herrero-Roldán Silvia , Rodriguez-Besteiro Stephanie , Martínez-Guardado Ismael , Martín-Rodríguez Alexandra , Tornero-Aguilera Jose Francisco
Published: October 2024

The increasing ubiquity of digital devices in childhood had outpaced the understanding of their effects on cognitive development, creating a significant research gap regarding their long-term impact. Objective: The present narrative overview explored the complex relationship between digital device usage and cognitive development in childhood. Methods: We conducted a comprehensive literature search across multiple databases, including PubMed, Embase, Scopus, and Web of Science, to critically assess cognitive domains such as attention, memory, executive functions, problem-solving skills, and social cognition. Incorporating over 157 peer-reviewed studies published between 2001 and 2024, we used strict inclusion and exclusion criteria to ensure scientific rigor. Results: The review integrated empirical findings with established theoretical frameworks, particularly from cognitive development and media psychology, to highlight both the advantages and risks of early, frequent exposure to technology. The potential for digital devices to enhance cognitive skills, such as multitasking and information processing, was weighed against risks such as cognitive overload, diminished attention spans, and impaired social skills. We also examined psychological and behavioral outcomes, including identity formation, emotional regulation, and maladaptive behaviors associated with excessive screen time. Additionally, we identified strategies to mitigate negative effects, emphasizing structured digital engagement and parental involvement to support healthy cognitive and psychological growth. Our findings provided actionable recommendations for parents, educators, and policymakers, promoting optimal digital practices that enhanced cognitive development while safeguarding against potential harms. Conclusions: The review offered essential insights for stakeholders in child development, education, and policy-making, highlighting the need for balanced integration of digital tools in childhood learning environments.
Exploring the Clinical Characteristics and Outcomes of Rhinovirus Infection in Hospitalized Children Compared with Other Respiratory Viruses
Authors: Covaci Sigrid , Filimon Claudiu , Craiu Mihai
Published: October 2024

Background: Acute viral respiratory tract infections constitute a significant challenge in pediatric healthcare globally, with rhinovirus representing one of the primary etiological agents. In this context, we conducted a study with the objective of identifying the clinical characteristics and outcomes of rhinovirus infection in comparison with other respiratory viruses in children hospitalized in one of the largest pediatric hospitals in the capital of Romania. Methods: We conducted a retrospective study among children hospitalized for influenza-like illness symptoms and who were tested by multiplex RT-PCR with a nasopharyngeal swab between May 2020 and December 2021. Results: A total of 496 children were eligible for inclusion in the study, and the positivity rate for at least one virus was 58.5%. The rhinovirus was identified in 138 patients (median age 12.5 months), representing 27.8% of all children tested and 49.3% of all positive samples. Although the clinical features of children with rhinovirus were dominated by cough (63.7%) and dyspnea (51.6%), no symptoms were identified that were strongly associated with rhinovirus infection in comparison to other respiratory viruses. The probability of receiving an antibiotic prescription was 1.92 times lower (p = 0.011) in children who tested positive for rhinovirus compared to children with negative RT-PCR results. The incidence of acute bronchiolitis or acute bronchitis, acute respiratory failure, and acute otitis media was higher among rhinovirus-positive children than among those who tested negative via RT-PCR. However, the incidence of these conditions was similar among children who tested positive for other respiratory viruses. Conclusions: Rhinovirus was the most prevalent virus identified in children hospitalized with influenza-like illness symptoms. The utilization of multiplex RT-PCR molecular tests is instrumental in elucidating etiology with precision and implementation of these advanced diagnostic methods, which can bring significant benefits in practice. A positive result for rhinovirus helps to reduce the unnecessary administration of antibiotics and optimizes patient management, thus decreasing the risk of severe complications such as acute respiratory failure and acute otitis media.
Effective Use of Euphorbia milii DCM Root Extract Encapsulated by Thermosensitive Immunoliposomes for Targeted Drug Delivery in Prostate Cancer Cells
Authors: Riet Keamogetswe , Adegoke Ayodeji , Mashele Samson , Sekhoacha Mamello
Published: October 2024

The delivery of anticancer drugs using nanotechnology is a promising approach aimed at improving the therapeutic efficacy and reducing the toxicity of chemotherapeutic agents. Liposomes were prepared using HSPC: DSPE–PEG–2000: DSPE–PEG2000–maleimide in the ratio of 4:1:0.2 and conjugated with a PSA antibody. Euphorbia milii extract (EME), doxorubicin (Dox), and docetaxel (Doc) encapsulated in temperature–sensitive immunoliposomes were investigated for their activities against the prostate cancer LNCap and DU145 cell lines. Organic extracts of EME leaves, roots, and stems were screened against both cell lines, inhibiting more than 50% of cell culture at concentrations of 10 μg/mL. The immunoliposomes incorporating the EME and docetaxel were active against the LNCap cells when exposed to heat at 39–40 °C. The liposomes not exposed to heat were inactive against the LNCap cells. The developed heat-sensitive immunoliposomes used for the delivery of both the EME and chemotherapeutic agents was able to successfully release the entrapped contents upon heat exposure above the phase transition temperature of the liposome membrane. The heat-sensitive immunoliposomes conjugated with a PSA antibody encapsulated the extract successfully and showed better cell antiproliferation efficacy against the prostate cancer cell lines in the presence of heat.
Degradation of Concrete Cement Stone Under the Influence of Aspergillus niger Fungi
Authors: Konovalova Viktoriya S. , Rumyantseva Varvara E. , Strokin Konstantin B. , Galtsev Aleksey A. , Novikov Denis G. , Monastyrev Pavel V.
Published: October 2024

The concepts of physical and chemical transformations occurring in cement concrete under conditions of microbiological deterioration can be used to control the processes of the destruction of cement concretes in order to ensure the required durability and to predict the service life of products. The study of changes in the structural and phase composition of cement stone made of Portland cement grade CEM I 42.5N in the process of fungal deterioration for 6 months when moistened, as well as a sample of a concrete wall exposed to fungal microorganisms for 20 years, was carried out. Diffractograms of the studied cement stone samples contain a large number of pronounced narrow peaks and indicate a highly crystalline structure of phases with the presence of an X-ray amorphous phase of calcium hydrosilicates and tobermorite gel in the cement stone. Changes in the structure of cement stone under the influence of fungi are confirmed by the data of a derivatographic analysis. A decrease in the content of calcium hydrosilicates and ettringite, as well as other crystalline phases in cement stone, leads to a decrease in compressive strength by about 15% over 6 months of fungal degradation. Similar changes after 20 years of exposure to microorganisms suggest deterioration in the strength characteristics of concrete.
Effect of Vacancy Defects on the Electronic Structure and Optical Properties of Bi4O5Br2: First-Principles Calculations
Authors: Huang Baorui , Liu Yeqi , Zhang Yanni , Zhang Fuchun , Yang Yanning , Li Jiaxin
Published: October 2024

First-principles calculations based on density functional theory are employed to investigate the impact of vacancy defects on the optoelectronic properties of Bi4O5Br2. The results indicate that vacancy defects induce minimal lattice distortion in Bi4O5Br2 without compromising its structural stability. Oxygen or bromine vacancies are more likely to occur than bismuth vacancies. The introduction of a bismuth vacancy leads to n-type semiconductor behavior in the Bi4O5Br2 system, while the creation of an oxygen vacancy reduces the bandgap and enhances the light absorption capacity. Bi4O5Br2 with three coordinated oxygen vacancies exhibits a higher effective electron–hole pair mass ratio, which is advantageous for the efficient separation of electron–hole pairs. Bi4O5Br2 with three coordinated oxygen vacancies exhibits enhanced absorption and reflection coefficients in the visible-light region compared to other systems, indicating that oxygen vacancy defects significantly promote visible-light absorption and electron–hole separation. This research provides new theoretical insights for understanding and optimizing the performance of photocatalysts based on Bi4O5Br2.
Phase Evolution, Mechanical, and Electrical Properties of Lightweight Ceramic Prepared Using Scoria at Low Temperature
Authors: Alraddadi Shoroog , Assaedi Hasan
Published: October 2024

This study aimed to produce lightweight, eco-friendly ceramic materials with superior properties using natural raw materials and low processing temperatures. Five ceramic samples were fabricated using red clay and varying contents of volcanic scoria (10%, 20%, 30%, 40%, and 50%) through sintering at 950 °C for 4 h. The crystalline phases, electrical properties, porosity, and mechanical strength of all the ceramic specimens were comprehensively evaluated. It was determined that the chemical composition of the raw materials and the resulting phases significantly influenced these various attributes. The XRD analysis revealed that the ceramic samples primarily consisted of the crystalline phases gehlenite, low quartz, and anorthite, along with the minor wollastonite and hematite phases. As the scoria content was increased, the MgO and Fe2O3 concentrations also increased, leading to a reduction in dielectric constant, dielectric loss, and electric conductivity. Moreover, the porosity of samples decreases from S10 to S50 due to the increase in the percentage of scoria and this reduction in porosity led to increased bending strength. The findings of this study suggest that volcanic scoria can serve as a viable eco-friendly raw material to produce lightweight ceramics with excellent electrical and mechanical properties, presenting cost-effective and energy-efficient solutions for various applications.
The Management of Non-Muscle-Invasive Bladder Cancer in a Veteran Patient Population: Issues and Recommendations
Authors: Taylor Jennifer , Patel Sagar , Gaitonde Krishnanath , Greene Kirsten , Liao Joseph C. , McWilliams Glen , Sawyer Mark , Schroeck Florian , Alrabaa Aly , Saffati Gal , Kronstedt Shane , Jones Jeffrey
Published: October 2024

The ability of the Veterans Health Administration System to care for veterans with bladder cancer is influenced by the increased complexity of both veterans and the system’s capacity to do so, which is determined by personnel and equipment allocation. Herein, we review the guidelines for bladder cancer management in the context of this population and highlight unique veteran characteristics that impact the delivery of bladder cancer care within the Veterans Health Administration System. There are opportunities for standardization and implementation, which can improve the quality of this care, and we summarize the questions for which coordinated research efforts may provide answers.
Clinical Outcomes of Poly(ADP–Ribose) Polymerase Inhibitors as Maintenance Therapy in Patients with Ovarian Cancer in the Southeastern Region of Korea
Authors: Ha Hyeong In , Yoon Hyung Joon , Song Changho , Kim Eun Taeg , Suh Dong-Soo , Kim Ki Hyung , Na Yong Jin , Song Yong Jung
Published: October 2024

Purpose: In this study, we aimed to retrospectively investigate the real-world clinical efficacy and adverse events of poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors in real-world clinical practice among patients with newly diagnosed epithelial ovarian cancer. Methods: We retrospectively reviewed the medical records from hospitals. Patients with epithelial ovarian cancer treated with olaparib or niraparib as frontline maintenance treatment between 1 January 2014 and 31 December 2022 were included. Progression-free survival (PFS) was analyzed using the Kaplan–Meier method, and adverse events associated with PARP inhibitor treatment were investigated. Results: Ninety-six patients treated with PARP inhibitors were identified. The median follow-up period was 21.8 months (95% confidence interval [CI] 19.4–24.0). Twenty (20.1%) patients experienced disease progression, and two patients died. The median PFS was 45.3 months (95% CI 39.4–NA). BRCA1 or BRCA2 gene mutations and primary cytoreductive surgery were associated with better PFS. Adverse events of any grade occurred in 74 (77.1%) patients. Nineteen (19.8%) patients experienced PARP inhibitor therapy interruptions, and 35 (36.5%) patients experienced dose reductions. Only three patients discontinued the drug due to adverse events. Conclusions: In a real-world setting, PARP inhibitors showed efficacy comparable to that reported in published randomized controlled trials and had acceptable safety profiles.
Potential Distribution and Carbon Sequestration of Rhizophora mangle L. in El Vizcaíno Biosphere Reserve, Baja California Sur, Mexico
Authors: Estrada-Contreras Israel , Bermúdez Alfredo , Castro Rodrigo Serrano , Ivanova Antonina
Published: October 2024

Mangroves are a type of vegetation distributed in warm areas of the planet. Despite their importance, this flora is seriously threatened by both human activities and climate change. One of the main benefits provided by mangroves is carbon capture and storage, which is key for climate change mitigation. The main objective of this study was to identify the potential distribution and carbon sequestration potential of Rhizophora mangle L. in El Vizcaíno Biosphere Reserve. Potential distribution models were obtained for Baja California Sur, Mexico, using the MaxLike algorithm. For each projection, we used bioclimatic variables from the WorldClim project for current and future conditions (2050 and 2070), two Shared Socioeconomic Pathways (SSP2-4.5 and SSP5-8.5) and three General Circulation Models (ACCESS-CM2, EC-Earth3-Veg and MPI-ESM1-2-HR). The potential distribution models were developed within the perimeter of El Vizcaíno Biosphere Reserve as a case study to establish the potential for carbon sequestration under different climate change scenarios. Our results show a possible future carbon sequestration from 10,177,174 Mg of CO2 and up to 14,022,367 Mg of CO2 for the ACCESS-CM2 SSP5-8.5 to 2070 and MPI-ESM1-2-HR SSP2-4.5 to 2070 projections, respectively. Mangrove species such as Rhizophora mangle can be an important part of climate change mitigation and adaptation.
Explainable Multi-Layer Dynamic Ensemble Framework Optimized for Depression Detection and Severity Assessment
Authors: Imans Dillan , Abuhmed Tamer , Alharbi Meshal , El-Sappagh Shaker
Published: October 2024

Background: Depression is a pervasive mental health condition, particularly affecting older adults, where early detection and intervention are essential to mitigate its impact. This study presents an explainable multi-layer dynamic ensemble framework designed to detect depression and assess its severity, aiming to improve diagnostic precision and provide insights into contributing health factors. Methods: Using data from the National Social Life, Health, and Aging Project (NSHAP), this framework combines classical machine learning models, static ensemble methods, and dynamic ensemble selection (DES) approaches across two stages: detection and severity prediction. The depression detection stage classifies individuals as normal or depressed, while the severity prediction stage further classifies depressed cases as mild or moderate-severe. Finally, a confirmation depression scale prediction model estimates depression severity scores to support the two stages. Explainable AI (XAI) techniques are applied to improve model interpretability, making the framework more suitable for clinical applications. Results: The framework’s FIRE-KNOP DES algorithm demonstrated high efficacy, achieving 88.33% accuracy in depression detection and 83.68% in severity prediction. XAI analysis identified mental and non-mental health indicators as significant factors in the framework’s performance, emphasizing the value of these features for accurate depression assessment. Conclusions: This study emphasizes the potential of dynamic ensemble learning in mental health assessments, particularly in detecting and evaluating depression severity. The findings provide a strong foundation for future use of dynamic ensemble frameworks in mental health assessments, demonstrating their potential for practical clinical applications.
Functional Outcomes and Self-Reported Quality of Life in Patients with Facial Nerve Impairment Following Vestibular Schwannoma Surgery
Authors: Franz Leonardo , Montino Silvia , Agostinelli Anna , Tealdo Giulia , Cazzador Diego , Zanoletti Elisabetta , Marioni Gino
Published: October 2024

Objective: The aim of this observational retrospective study was to report quality of life (QoL) in patients with postoperative facial nerve (FN) palsy after vestibular schwannoma (VS) surgery, investigating clinical factors related to functional outcomes. Methods: Forty-eight consecutive patients (M:F 25:23; median age: 52.5 years) with facial palsy following surgery for sporadic VS were considered retrospectively. FN palsy was graded by using the Sunnybrook facial grading system (SBFGS), while postoperative QoL and subjective functional aspects were assessed by using the Penn Acoustic Neuroma Quality of Life (PANQOL) Scale, the Synkinesis Assessment Questionnaire, and questions on eating and drinking. Results: A significant correlation emerged between all Sunnybrook scores and median PANQOL domain regarding facial function. Increasing overall SBFGS scores were associated with reduced risk of slow chewing on the affected side (p = 0.004), lack of masticatory strength (p = 0.025), masticatory fatigue (p < 0.001), accumulation of food in the oral vestibule (p < 0.001), difficulty in drinking from a glass (p = 0.019), and fluid spillage while drinking (p = 0.016). Conclusions: This study suggests that the clinical evaluation of patients with FN palsy after VS surgery should be integrated with patient reports about functional outcomes and perceived QoL to help clinicians guide rehabilitation choices.
Usefulness of Atherogenic Indices for Predicting High Values of Avoidable Lost Life Years Heart Age in 139,634 Spanish Workers
Authors: Sastre-Alzamora Tomás , Tárraga López Pedro J. , López-González Ángel Arturo , Vallejos Daniela , Paublini Hernán , Ramírez Manent José Ignacio
Published: October 2024

Background: Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, accounting for one-third of all global deaths. The World Health Organization (WHO) asserts that prevention is the most effective strategy to combat CVD, emphasizing the need for non-invasive, low-cost tools to identify individuals at high risk of CVD. Atherogenic indices and heart age (HA) are valuable tools for assessing cardiovascular risk (CVR). The aim of our study was to evaluate the association between atherogenic indices and HA. Methods: A cross-sectional study was conducted involving 139,634 Spanish workers to determine the association between three atherogenic indices and HA. ROC curves were employed to identify the cut-off values for the various atherogenic indices used to estimate high HA. The cut-off points, along with their sensitivity, specificity, and Youden index, were determined, and the area under the curve (AUC) was calculated. Results: As the values of the atherogenic indices increased, so did the risk of having elevated avoidable lost life years (ALLY) HA. In the ROC curve analysis, the AUC with the best results corresponded to the total cholesterol/HDL-c atherogenic index, with an AUC of 0.803 in females and 0.790 in males. The LDL-c/HDL-c atherogenic index showed an AUC of 0.780 in women and 0.750 in men, with Youden indices around 0.4. When analyzing the AUC of the atherogenic index for triglycerides/HDL-c, the results were 0.760 in women and 0.746 in men. Conclusions: Atherogenic indices and HA show a close relationship, with an increase in these indices leading to a rise in HA values. Raising patient awareness that as their CVR levels increase, so does their HA may be useful in achieving some benefit in reducing CVR.
Developmental Patterns and Risk Factors of Scoliosis After Hemipelvectomy for the Pelvic Bone Tumor
Authors: Tsuchiya Ryuto , Iwata Shintaro , Fukushima Suguru , Osaki Shuhei , Ogura Koichi , Kobayashi Eisuke , Ohtori Seiji , Kawai Akira
Published: October 2024

Background: Postoperative scoliosis is often seen after hemipelvectomy for malignancies involving the pelvic area, but the details remain unclear. The objectives were to investigate the development patterns and risk factors of scoliosis after hemipelvectomy. Methods: We retrospectively reviewed 30 patients who underwent hemipelvectomy at our hospital between 1998 and 2020. The risk factors of scoliosis with a Cobb angle of ≥10° were investigated. Results: The postoperative Cobb angle significantly increased in all patients compared with the preoperative one (p < 0.001), and the change ratio of the Cobb angle was significantly higher during the first postoperative year than thereafter. The external hemipelvectomy (EH) group demonstrated a larger Cobb angle and a higher change ratio than the internal hemipelvectomy group. Nine patients developed scoliosis with a final Cobb angle of ≥10°, and the risk factors were EH (p = 0.017), P1+2+3+4 resection according to the Enneking classification (p = 0.005), iliac crest resection (p = 0.004), L5/S resection (p = 0.020), and no pelvic ring reconstruction after hemipelvectomy (p = 0.004). Conclusions: Approximately 30% of patients who underwent hemipelvectomy developed scoliosis with a Cobb angle of ≥10°, and this angle increased rapidly during the first postoperative year. Hence, careful follow-up of scoliosis is required after hemipelvectomy.
Applications of ChatGPT in Heart Failure Prevention, Diagnosis, Management, and Research: A Narrative Review
Authors: Ghanta Sai Nikhila , Al’Aref Subhi J. , Lala-Trinidade Anuradha , Nadkarni Girish N. , Ganatra Sarju , Dani Sourbha S. , Mehta Jawahar L.
Published: October 2024

Heart failure (HF) is a leading cause of mortality, morbidity, and financial burden worldwide. The emergence of advanced artificial intelligence (AI) technologies, particularly Generative Pre-trained Transformer (GPT) systems, presents new opportunities to enhance HF management. In this review, we identified and examined existing studies on the use of ChatGPT in HF care by searching multiple medical databases (PubMed, Google Scholar, Medline, and Scopus). We assessed the role of ChatGPT in HF prevention, diagnosis, and management, focusing on its influence on clinical decision-making and patient education. However, ChatGPT faces limited training data, inherent biases, and ethical issues that hinder its widespread clinical adoption. We review these limitations and highlight the need for improved training approaches, greater model transparency, and robust regulatory compliance. Additionally, we explore the effectiveness of ChatGPT in managing HF, particularly in reducing hospital readmissions and improving patient outcomes with customized treatment plans while addressing social determinants of health (SDoH). In this review, we aim to provide healthcare professionals and policymakers with an in-depth understanding of ChatGPT’s potential and constraints within the realm of HF care.
Correction: Goidescu et al. Is Hysteroscopic Metroplasty Advisable for U2bC2V1 Malformation? Diagnostics 2024, 14, 1649
Authors: Goidescu Iulian Gabriel , Staicu Adelina , Poienar Alexandra-Andreea , Surcel Mihai , Micu Romeo , Boitor Borza Dan , Muresan Daniel
Published: October 2024

Dan Boitor Borza was not included as an author in the original publication [...]
Multi-Batch Carrier-Based UAV Formation Rendezvous Method Based on Improved Sequential Convex Programming
Authors: Zhang Zirui , Sun Liguo , Wang Yanyang
Published: October 2024

The limitations of the existing catapults necessitate multiple batches of take-offs for carrier-based unmanned aerial vehicles (UAVs) to form a formation. Because of the differences in takeoff time and location of each batch of UAVs, ensuring the temporal and spatial consistency and rendezvous efficiency of the formation becomes crucial. Concerning the challenges mentioned above, a multi-batch formation rendezvous method based on improved sequential convex programming (SCP) is proposed. A reverse solution approach based on the multi-batch rendezvous process is developed. On this basis, a non-convex optimization problem is formulated considering the following constraints: UAV dynamics, collision avoidance, obstacle avoidance, and formation consistency. An SCP method that makes use of the trust region strategy is introduced to solve the problem efficiently. Due to the spatiotemporal coupling characteristics of the rendezvous process, an inappropriate initial solution for SCP will inevitably reduce the rendezvous efficiency. Thus, an initial solution tolerance mechanism is introduced to improve the SCP. This mechanism follows the idea of simulated annealing, allowing the SCP to search for better reference solutions in a wider space. By utilizing the initial solution tolerance SCP (IST-SCP), the multi-batch formation rendezvous algorithm is developed correspondingly. Simulation results are obtained to verify the effectiveness and adaptability of the proposed method. IST-SCP reduces the rendezvous time from poor initial solutions without significantly increasing the computing time.
Prepare Linear Distributions with Quantum Arithmetic Units
Authors: Li Junxu
Published: October 2024

Quantum arithmetic logic units (QALUs) perform essential arithmetic operations within a quantum framework, serving as the building blocks for more complex computations and algorithms in quantum computing. In this paper, we present an approach to prepare linear probability distributions with quantum full adders. There are three main steps. Firstly, Hadamard gates are applied to the two input terms, preparing them at quantum states corresponding to uniform distribution. Next, the two input terms are summed up by applying quantum full adder, and the output sum is treated as a signed integer under two’s complement representation. By the end, additional phase −1 is introduced to the negative components. Additionally, we can discard either the positive or negative components with the assistance of the Repeat-Until-Success process. Our work demonstrates a viable approach to prepare linear probability distributions with quantum adders. The resulting state can serve as an intermediate step for subsequent quantum operations.
Early Desertification Risk in Advanced Economies: Summarizing Past, Present and Future Trends in Italy
Authors: Maialetti Marco , Halbac-Cotoara-Zamfir Rares , Vardopoulos Ioannis , Salvati Luca
Published: October 2024

Being located in the middle of Southern Europe, and thus likely representing a particularly dynamic member of Mediterranean Europe, Italy has experienced a sudden increase in early desertification risk because of multiple factors of change. Long-term research initiatives have provided relatively well-known examples of the continuous assessment of the desertification risk carried out via multiple exercises from different academic and practitioner stakeholders, frequently using the Environmentally Sensitive Area Index (ESAI). This composite index based on a large number of elementary variables and individual indicators—spanning from the climate to soil quality and from vegetation cover to land-use intensity—facilitated the comprehensive, long-term monitoring of the early desertification risk at disaggregated spatial scales, being of some relevance for policy implementation. The present study summarizes the main evidence of environmental monitoring in Italy by analyzing a relatively long time series of ESAI scores using administrative boundaries for a better representation of the biophysical and socioeconomic trends of interest for early desertification monitoring. The descriptive analysis of the ESAI scores offers a refined representation of economic spaces in the country during past (1960–2010 on a decadal basis), present (2020), and future (2030, exploring four different scenarios, S1–S4) times. Taken as a proxy of the early desertification risk in advanced economies, the ESAI scores increased over time as a result of worse climate regimes (namely, drier and warmer conditions), landscape change, and rising human pressure that exacerbated related processes, such as soil erosion, salinization, compaction, sealing, water scarcity, wildfires, and overgrazing.
Optimizing the Migratory Environment of Wildebeests in the Maasai Mara Reserve with a New Ecological Corridor and Customized Buffer Zone Model
Authors: Fan Xinrui , Tang Kuok Ho Daniel , Liu Shoushuo , Liu Yang , Smith Charles Ken
Published: October 2024

Conflicts between wildlife and humans are a major ecological issue. During migration, wildlife, especially wildebeest, often encounter significant environmental pressures from human activities. However, relatively few studies have been conducted to provide a concise, quantitative description of wildebeest migration in the Maasai Mara National Reserve (MMNR). In this study, we identified changes in the location of the wildebeest population over time in the Maasai Mara National Reserve. We then used a K-means algorithm (R2 = 0.926) to fit coordinates representing the changes in the location of the wildebeests to enable a quantitative representation of their migration routes. Subsequently, we developed an environmental stress model to assess the changes in environmental stresses faced by wildebeests along their migration routes. We proposed a model of “migratory ecological corridors and customized buffer zones” and determined the response coefficient T_res. We used the response coefficients T_res = 0.06, 0.09, and 0.12 as the critical values to categorize the areas along the routes into weak, medium, and strong response regions. Then, we set the width of the buffer zones on both sides of the routes as 5 km, 7 km, and 9 km, respectively, and evaluated the buffer effect. This type of model achieved a good effect of reducing the environmental pressure by 54.06%. The “Migratory Ecological Corridor and Customized Buffer Zone” model demonstrated a high degree of economic feasibility while showing good practicality in mitigating the environmental conflicts between humans and migratory wildlife. The variability in the environmental pressures across the region indicates that the Nairobi and Nakuru districts may be undergoing a particular stage of urbanization that unleashes potential threats to the migration of wildebeests. Further research is essential to assess the feasibility of larger buffer zones.
Financial Development and Climate Change: A Detailed Bibliometric Investigation
Authors: Badareu Gabriela , Doran Marius Dalian , Firu Mihai Alexandru , Olaru Sergiu Mihail , Doran Nicoleta Mihaela
Published: October 2024

This paper presents a detailed bibliometric analysis of the interaction between financial development and climate change, with the main aim of elucidating the current state of research in this area, identifying existing gaps, and guiding future researchers interested in this rapidly expanding field. The study used VOSviewer software version 1.6.18 to analyze the bibliometric data, facilitating the mapping of co-author networks, institutional collaborations, and the identification of main research directions. Through this tool, 730 papers from the Web of Science database covering the period 2010–2024 were extracted and analyzed. The study highlights the authors and institutions that have made significant contributions to the investigation of the relationship between financial development and climate change. The identification of key contributors and international collaborative networks provides a solid foundation for future research and policy initiatives. In addition, the study identifies the most prolific journals and assesses the quality and impact of the research. This allows for a deeper understanding of current research directions and potential future developments. The study not only clarifies the current state of research but also opens up new opportunities for investigating innovative and sustainable solutions aimed at improving the quality of life and protecting the environment.
Curriculum, Instruction, and Assessment in Middle Level Teacher Development: A Research Synthesis
Authors: Terrell Shockley Ebony , Wall Amanda , Pettit Stacie K.
Published: October 2024

We used Standards 3 and 4 of the Association of Middle Level Education (AMLE) 2022 Revised Middle Level Teacher Preparation Standards and The Successful Middle School: This We Believe characteristics as frameworks and presented a synthesis of the research literature (2015–2024) on the curriculum, instruction, and assessment related to middle-level teacher development. This review was part of a larger exploration of middle-level teacher development. Initially, we located 63 articles through our search terms on the curriculum, instruction, and assessment in teacher development. From there, we contributed to an updated research agenda for middle-level education . Through continued analysis and discussion, we identified trends in each area and across these three areas. We review the literature, highlight trends, and offer recommendations for middle-level educators and researchers.
Worker Presence Monitoring in Complex Workplaces Using BLE Beacon-Assisted Multi-Hop IoT Networks Powered by ESP-NOW
Authors: Uddin Raihan , Hwang Taewoong , Koo Insoo
Published: October 2024

The increasing adoption of Internet of Things (IoT) technologies has facilitated the creation of advanced applications in various industries, notably in complex workplaces where safety and efficiency are paramount. This paper addresses the challenge of monitoring worker presence in vast workplaces such as shipyards, large factories, warehouses, and other construction sites due to a lack of traditional network infrastructure. In this context, we developed a novel system integrating Bluetooth Low Energy (BLE) beacons with multi-hop IoT networks by using the ESP-NOW communications protocol, first introduced by Espressif Systems in 2017 as part of its ESP8266 and ESP32 platforms. ESP-NOW is designed for peer-to-peer communication between devices without the need for a WiFi router, making it ideal for environments where traditional network infrastructure is limited or nonexistent. By leveraging the BLE beacons, the system provides real-time presence data of workers to enhance safety protocols. ESP-NOW, a low-power communications protocol, enables efficient, low-latency communication across extended ranges, making it suitable for complex environments. Utilizing ESP-NOW, the multi-hop IoT network architecture ensures extensive coverage by deploying multiple relay nodes to transmit data across large areas without Internet connectivity, effectively overcoming the spatial challenges of complex workplaces. In addition, the Message Queuing Telemetry Transport (MQTT) protocol is used for robust and efficient data transmission, connecting edge devices to a central Node-RED server for real-time remote monitoring. Moreover, experimental results demonstrate the system’s ability to maintain robust communication with minimal latency and zero packet loss, enhancing worker safety and operational efficiency in large, complex environments. Furthermore, the developed system enhances worker safety by enabling immediate identification during emergencies and by proactively identifying hazardous situations to prevent accidents.
Dq-YOLOF: An Effective Improvement with Deformable Convolution and Sample Quality Optimization Based on the YOLOF Detector
Authors: Qi Xiaoxia , Md Johar Md Gapar , Khatibi Ali , Tham Jacquline , Cheng Long
Published: October 2024

Single-stage detectors have drawbacks of insufficient accuracy and poor coverage capability. YOLOF (You Only Look One-level Feature) has achieved better performance in this regard, but there is still room for improvement. To enhance the coverage capability for objects of different scales, we propose an improved single-stage object detector: Dq-YOLOF. We have designed an output encoder that employs a series of modules utilizing deformable convolution and SimAM (Simple Attention Module). This module replaces the dilated convolution in YOLOF. This design significantly improves the ability to express details. Simultaneously, we have redefined the sample selection strategy, which optimizes the quality of positive samples based on SimOTA. It can dynamically allocate positive samples according to their quality, reducing computational load and making it more suitable for small objects. Experiments conducted on the COCO 2017 dataset also verify the effectiveness of our method. Dq-YOLOF achieved 38.7 AP, 1.5 AP higher than YOLOF. To confirm performance improvements on small objects, our method was tested on urinary sediment and aerial drone datasets for generalization. Notably, it enhances performance while also lowering computational costs.