bluuebunny/crossref_metadata_2025 huggingface dataset:
Controlling the Reactivity of Enzymes in Mechanochemistry: Inert Surfaces Protect β-Glucosidase Activity During Ball Milling
Authors: Hammerer Fabien , Ostadjoo Shaghayeh , Friscic Tomislav , Auclair Karine
Published: July 2019

Although cellulose has been identified as the foremost candidate for the replacement of fossil fuels, its recalcitrant nature prevents the full deployment of technologies based on its saccharification. We recently reported a possible strategy to resolve this conundrum: using cellulases under “RAging” - a solvent-free process that utilizes enzymes under mechanochemical conditions - to achieve fast, efficient hydrolytic depolymerization of cellulosic materials into glucose. β-Glucosidases catalyze the last and often limiting step of this process, i.e. the formation of glucose from cellobiose. Here, we reveal the high sensitivity of β-glucosidases to ball milling, as well as an unexpected stabilization effect of inert surfaces, enabling the protection of β-glucosidases under mechanochemical treatment. This approach provides an unexpected strategy to control the reactivity of enzymes under mechanochemical conditions. Finally, our results also provide the very first demonstration of enzymatic equilibrium under mechanochemical conditions.
Potent Hemithioindigo-Based Antimitotics Photocontrol the Microtubule Cytoskeleton in Cellulo
Authors: Sailer Alexander , Ermer Franziska , Kraus Yvonne , Bingham Rebekkah , Lutter Ferdinand H. , Ahlfeld Julia , Thorn-Seshold Oliver
Published: July 2019

Hemithioindigo is a promising molecular photoswitch that has only recently been applied as a photoswitchable pharmacophore for control over bioactivity in cellulo. Uniquely, in contrast to other photoswitches that have been applied to biology, the pseudosymmetric hemithioindigo scaffold has allowed the creation of both dark-active and lit-active photopharmaceuticals for the same binding site by a priori design. However, the potency of previous hemithioindigo photopharmaceuticals has not been optimal for their translation to other biological models. Inspired by the structure of tubulin-inhibiting indanones, we created hemithioindigo-based indanone-like tubulin-inhibitors (HITubs) and optimised their cellular potency as antimitotic photopharmaceuticals. These HITubs feature reliable and robust visible light photoswitching and high fatigue resistance. The use of the hemithioindigo scaffold also permitted us to employ a para-hydroxy hemistilbene motif – a structural feature which is denied to most azobenzenes due to the negligibly short lifetimes of their metastable Z isomers – which proved crucial to enhancing the potency and photoswitchability. The HITubs are ten times more potent than previously reported hemithioindigo photopharmaceutical antimitotics in a series of cell-free and cellular assays, and allowed robust photocontrol over tubulin polymerisation, microtubule network structure, cell cycle and cell survival. We conclude that HITubs represent a powerful addition to the growing toolbox of photopharmaceutical reagents for microtubule cytoskeleton research. Additionally, as the hemithioindigo scaffold allows photoswitchable bioactivity for substituent patterns inaccessible to the majority of current photopharmaceuticals, wider adoption of the hemithioindigo scaffold may significantly expand the scope cellular and in vivo targets addressable by photopharmacology.
Evaluation of Binding Site Comparison Algorithms and Proteometric Machine Learning Models in the Detection of Protein Pockets Capable of Binding the Same Ligand
Authors: Gaieb Zied , parks conor , Amaro Rommie
Published: July 2019

Non linearities of biological networks present ample opportunity for synergistic protein targeting combinations. Yet, to date, our ability to design multi-target inhibitors and predict polypharmacology binding profiles remains limited. Herein, we present a systematic benchmarking of protein pocket comparison algorithms from the literature, as well as novel machine learning models developed to predict whether two proteins will bind the same ligand. The results demonstrate that previously reported performance metrics from the literature could be inflated due to a bias towards proteins of similar folds when identifying protein capable of binding the same ligand. This observation motivated a more in-depth evaluation of the methods against two subsets of same and cross protein fold comparisons. In a head to head comparison using the cross protein fold subset, we found that the proteometric machine learning models were the best performing models overall.
Alcançando um público estrangeiro
Authors: De Matos Morgana Aparecida , Moura Willian Henrique Cândido , Gehin Antonia Elizangela de Morais
Published: July 2019

Este artigo analisa algumas das questões que envolvem a tradução intercultural de filmes. Centra-se na tradução de referências e questões culturais específicas, particularmente, a validade das noções de estrangeirização e domesticação em Estudos da Tradução, elaboradas por Venuti (1995), como uma abordagem conceitual tradicionalmente usada para discutir as estratégias empregadas no processo de tradução de referências culturais. Com base nos resultados obtidos em um estudo piloto composto de três filmes franceses dublados e legendados para o inglês, este artigo sugere um desafio teórico ao propor uma abordagem mais pragmática para o estudo da transferência cultural em tradução audiovisual (TAV). De modo particular, propõe a analisar se é possível observar qualquer forma de regularidade no emprego de estratégias de tradução de referências culturais, assim como de que maneira isso impacta as relações dialógicas entre o Eu e o Outro e a representação da alteridade.
Teaching the generalisable skills of cultural competency: A new educational intervention in New Zealand
Authors:   Department of Family Medicine, Sackler Faculty of Medicine, Tel Aviv University, Israel, Thomas Katharine D. , Schofield Susie ,   Centre for Medical Education, University of Dundee, United Kingdom
Published: July 2019

Context: In the twentieth century “cultural” courses in medical education focused on imparting knowledge about ethnic and racial minorities. A new consensus has developed that emphasises a broader definition of culture: education should promote generalisable skills enabling effective interactions with all patients in our culturally complex world. In New Zealand, cultural competency is frequently taught within courses on the indigenous Māori people. This study evaluated whether a generalisable cultural competency intervention was acceptable and effective in this setting. Methods: A generalisable cultural competency workshop was run for 17 general practitioners. A self-assessment questionnaire was completed by attendees and by a control group of 19 GPs. Participants provided feedback during the seminar and through standardised evaluation forms. Four medical education professionals were interviewed to explore their views on cultural competency education. The interviews were transcribed and thematically analysed. Results: The questionnaires showed a non-significant, post-seminar increase in total cultural competency score by the seminar participants as compared with the control group (p= .33). Feedback was positive, with all respondents considering the seminar relevant to their needs. The interviewees supported generalisable cultural competency but lacked consensus around whether it should stand-alone or be embedded in ethnically-focused education. Conclusions: This pilot study shows that participants found generalisable cultural competency education acceptable and that they perceived an improvement in their skills. Medical educators disputed the role of generalisable cultural competency. Further research is needed into how it can be utilised in New Zealand.
Peningkatan Pengenalan Sains Pada Anak Melalui Kegiatan Menanam Sayuran Kelompok B4 Semester Ganjil di TK Pertiwi Metro Tahun Pelajaran 2017-2018
Authors: Muchsonny Muchsonny , Hidayatullah Rizky , Anwar Muhammad Saidun
Published: July 2019

Penelitian ini dilakukan untuk mengetahui sejauh mana manfaat menanam sayuran untuk meningkatkan pengenalan sains pada anak di kelompok B4  TK Pertiwi Metro. Masalah yang  dibahas dalam penelitian ini adalah manfaat menanam sayuran untuk meningkatkan pengenalan sains pada anak di kelompok B4. Penelitian ini menggunakan Penelitian Tindakan Kelas (PTK) dengan 2 siklus. Setiap siklus ada 4 tahapan yaitu: perencanaan, tindakan, pengamatan dan refleksi. Obyek penelitian dilaksanakan pada TK Pertiwi Metro Tahun Pelajaran 2017-2018.Alat pengumpul data yang digunakan dalam peneltian ini adalah dengan observasi langsung dengan langkah-langkah pengumpulan data, analisis data, dan mengambil kesimpulan untuk mengetahui sejauh mana manfaat manfaat menanam sayuran untuk meningkatkan pengenalan sains pada anak dan dilakukan analisis secara deskriptif. Penelitian               ini diharapkan berdampak menjadikan  anak-anak lebih mampu, lebih teliti, lebih senang dan lebih percaya diri dalam mengikuti proses pembelajaran.khususnya pada pengenalan sains
Efektivitas Kegiatan Outbound Fun Estafet untuk Meningkatkan Perkembangan Sosial Anak di Taman Kanak–Kanak Al-Jannah Tarusan Kabupaten Pesisir Selatan
Authors: Yeni Rolla Afriza , Aulia Prima
Published: July 2019

The purpose of this study was determine the effectiveness of relay outbound fun activities on improving social development of children in aljannah tarusan kindergarten kabupaten pesisir selatan. In this study quantitative research in the form of quasy experiments was used. The result showed that according ti the analysis of indpendent data from the sample t-test using SPSS for windows 23, previously the normality and hmogenity test were carried out, and also with the N-Gain score test. The result obtained sig (2-tailed) 0,012 <0,05 means that there is a significant (significant) difference in effectiveness between the treatment given by the teacher and the treatmeant of relay outbound fun activities to improve children’s social development. Based on the analysis of the result of the hypothesis test and the effect test, it was concluded that the effective relay outbound activity was effective to enhance the social development of children at al-jannah Tarusan Kindergarten, Kabupaten Pesisir Selatan.
XIX Encuesta Nacional de Seguridad Informática
Authors: Almanza J. Andres R.
Published: July 2019

La encuesta nacional de seguridad informática, capítulo Colombia, soportada por la Asociación Colombiana de Ingenieros de Sistemas (ACIS) y realizada a través de Internet, entre los meses de febrero y abril de 2019, contó con la participación de 299 encuestados, quienes con sus respuestas revelan tendencias particulares para Colombia en los temas de seguridad y control. Este ejercicio fue motivado a través de diferentes redes sociales, comunidades y grupos, y contó con la cooperación de otras asociaciones como ISACA, Capítulo Bogotá, TacticalEdge, y CISOS.CLUB. Los resultados de este estudio muestran un panorama de las organizaciones colombianas, en sus distintos sectores productivos, frente a la seguridad de la información y/o ciberseguridad y su evolución en las diferentes dimensiones incluidas en la encuesta.
Efektifitas Pelaksanaan Kurikulum 2013 ditinjau dari Kesiapan Sekolah dan Pengaruhnya terhadap Perkembangan Sekolah
Authors: Suluh Melkianus , Ate Dekriati
Published: July 2019

Abstract: This study aims to determine: (1) school readiness and response to the 2013 curriculum, (2) the effectiveness of the 2013 curriculum implementation on school development, (3) the supporting and inhibiting factors for the implementation of the 2013 curriculum in physics learning, and (4) Implementation of process standards and curriculum evaluation standards for 2013. This research is a qualitative descriptive study. The research subjects were Physics Teachers, Mathematics Teachers, and Indonesian Teachers. Research data was collected by conducting in-depth interviews. The results of the study show that: 1) the principal and teacher state the readiness for the implementation of the 2013 curriculum. 2) the application of the 2013 curriculum influences the efforts of schools to develop schools through increasing teacher human resources, providing supporting facilities and infrastructure and learning facilities; 3) supporting factors for the implementation of the 2013 curriculum are the availability of adequate teacher resources, the availability of adequate supporting facilities and infrastructure, the support of parents and the government, and the willingness of students. Meanwhile, the inhibiting factors are minimal learning media, limited student books, limited educational staff, readiness and teacher thinking methods that still use old learning patterns; 4) teachers have difficulty implementing scientific approach based learning due to lack of student enthusiasm, minimal learning media, limited laboratory and library facilities and infrastructure, for aspects of assessment teachers experience difficulties with the number of items and forms of assessment.Keywords: 2013 curriculum; School Readiness; School Development
Nucleophilic Addition of Potassium O-Ethyl Dithiocarbonate to Baylis-Hillman Adducts Using 9-BBN as Catalyst
Authors: Hernández-Ibinarriaga Ilsa , Miranda Luis D.
Published: July 2019

An efficient diastereoselective Michael addition of the commercial potassium O-ethyl dithiocarbonate to Baylis-Hillman adducts in the presence of 9-BBN (9-borabicyclo[3.3.1]nonane) as a Lewis acid is reported. 9-BBN both protected the hydroxyl group and activated the carbonyl of the Michael acceptor.
Study of Sorption Equilibrium of Biopolymers Alginic Acid and Xanthan with C.I. Disperse Yellow 54
Authors: Lozano-Álvarez Juan Antonio , Jáuregui-Rincón Juan , Mendoza-Díaz Guillermo , Rodríguez-Vázquez Refugio , Frausto-Reyes Claudio
Published: July 2019

Disperse yellow 54 (DY54) was adsorbed onto two biopolymers, alginic acid and xanthan. The adsorption isotherms for the biopolymer-DY54 system showed that the adsorption mechanism can best be described by Zimm-Bragg theory. UV-Visible, FT-IR and MicroRaman studies suggest that DY54 is bounded to both biopolymers alginic acid and xanthan through hydrogen bonding. Keto group of dye and hydroxyl groups of sugar residues from two polysaccharides were the principal functional groups involved in sorption mechanism.
Kinetic Study on Methanol Dehydration to Dimethyl Ether Applying Clinoptilolite Zeolite as the Reaction Catalyst
Authors: Kasaie Maryam , Sohrabi Morteza
Published: July 2019

Dehydration of methanol to dimethyl ether (DME), using clinoptilolite-zeolite as the reaction catalyst, within the temperature range of 300-350 °C has been studied in a continuous fluidized bed reactor. The reactor was a cylindrical tube, 26 mm internal diameter and 0.5 m high, placed vertically in a furnace. The effects of some pertinent operating parameters, such as temperature, superficial gas velocity, catalyst’s particle size, and methanol partial pressure, on the extent of dehydration reaction have been investigated. Two hydrodynamic models presented for bubbling fluidized bed reactors, i.e., Kunii - Levenspiel (K-L) as an example of three phase models and El-Halwagi - El-Rifai (H-R) as an example of compartment models were applied to correlate the experimental data. It was determined that the mean absolute deviation between the experimental data and those predicted from K-L model was lower than that observed in the case of H-R model (19% and 70%, respectively). Among the operating parameters, partial pressure of methanol was found to have the highest impact on the process yield.
Uranium Sorption on “Tezontle” Volcanic Rock
Authors: López Muñoz Beatriz Eugenia , Durán Blanco Juana María , Iturbe García José Luis , Olguín Gutiérrez María Teresa
Published: July 2019

It is described a study that demonstrates that hexavalent uranium ions were sorbed by the naturally occurring mineral using a batch technique. This mineral is found in abundant quantities in Mexico. Our study focused on the separation of UVI from synthetic aqueous systems of both H2O-UO2(NO3)2.6H2O (acid) and H2ONa4[ UO2(CO3)3] (basic). The chemical speciation was performed by using high voltage electrophoresis, and the uranium content was determined by UV-Vis Spectroscopy. The quantified U(VI) sorption by tezontle from acidic and basic systems was 2.72 and 1.68 μmol/g, respectively, and the sorption behavior is discussed considering the surface charge of the tezontle at different pH values based on the point of zero charge characteristic of this material.
Spectroscopic and Mechanical Studies on the Fe-based Amorphous Alloy 2605SA1
Authors: Cabral-Prieto Agustín , Contreras-Vite Juan Antonio , García-Sosa Irma , Nava Noel , García-Santibáñez Federico
Published: July 2019

The Vickers micro-hardness of this alloy was unusually dependent on the heat treatment from 300 to 634K, inferring important micro-structural changes and the presence of amorphous grains before its phase transition. Once the alloy is crystallized, the microhardness is characteristic of a brittle alloy, the main problem of these alloys. Within the amorphous state, other properties like free-volume, magnetic states and Fe-Fe distances were followed by PALS and MS, respectively, to analyze those micro-structural changes, thermally induced, which are of paramount interest to understand their brittleness problem.
Uptake of CrO42- Ions by Fe-Treated Tri-Calcium Phosphate
Authors: Serrano-Gómez Juan , Ramírez-Sandoval Jorge Luis , Bonifacio- Martínez Juan , Granados-Correa Francisco , Badillo-Almaraz Verónica Elizabeth
Published: July 2019

CrO42- ion adsorption on Fe-treated tri-calcium phosphate was studied by batch experiments as a function of contact time, initial concentration of metal ion and temperature. Adsorption results showed that at pH 5.5 and 1.0x10-4 M chromium concentration the adsorption capacity of Fe-treated tri-calcium phosphate for CrO42- ions was 7.10x10-3 mmol/g. Chromium adsorption data on Fe-treated tri-calcium phosphate at various initial concentration fitted the Freundlich isotherm. By temperature studies the thermodynamic parameters ∆H0, ∆G0 and ∆S0 were estimated and the obtained results showed that the adsorption reaction was endothermic and spontaneous.
Synthesis of the Mg2Ni Alloy Prepared by Mechanical Alloying Using a High Energy Ball Mill
Authors: Iturbe-García José Luis , García-Núñez Manolo Rodrigo , López-Muñoz Beatriz Eugenia
Published: July 2019

Mg2Ni was synthesized by a solid state reaction from the constituent elemental powder mixtures via mechanical alloying. The mixture was ball milled for 10 h at room temperature in an argon atmosphere. The high energy ball mill used here was fabricated at ININ. A hardened steel vial and three steel balls of 12.7 mm in diameter were used for milling. The ball to powder weight ratio was 10:1. A small amount of powder was removed at regular intervals to monitor the structural changes. All the steps were performed in a little lucite glove box under argon gas, this glove box was also constructed in our Institute. The structural evolution during milling was characterized by X-ray diffraction and scanning electron microscopy techniques. The hydrogen reaction was carried out in a micro-reactor under controlledconditions of pressure and temperature. The hydrogen storage properties of mechanically milled powders were evaluated by using a TGA system. Although homogeneous refining and alloying take place efficiently by repeated forging, the process time can be reduced to one fiftieth of the time necessary for conventional mechanical milling and attrition.
Synthesis and Biological Activity of Novel 6-Substituted Purine Derivatives
Authors: Hu Yu Lin , Liu Xiang , Lu Ming
Published: July 2019

A series of 6-substituted purines were synthesized from commercially available 2-amino-6-chloropurine with appropriate reagents, and nine new compounds 7, 8, and 11-17 have been discovered. The compounds synthesized were identified by elemental analysis, 1H NMR, as well as mass spectral data. All the title compounds were screened for their antifungal activities, under the method of the disc diffusion, using three species of fungi — Bacillus subtillis, Aspergillus niger, and Candida tropicalis— and some of the compounds showed promising activities.
People, Travel, Seminars, Reading, the Classroom, and Curiosity-Sources of Research Inspiration
Authors: Little R. Daniel
Published: July 2019

This manuscript is the outgrowth of a plenary lecture delivered by the author at the 44th Congreso Mexicano de Química that was held in Puebla, Mexico from 26-30 September of 2009. In formulating the presentation, consideration was given to thinking about the origins of the ideas that were integral to the formulation of the research to be described. The intent was to address the younger members of the audience – advanced undergraduate and graduate students, and those beginning the process of searching for a job. At a similar stage in my scientific career, I realized the need to formulate research plans in order to complete job applications where they were required. Where do these ideas come from? What factors stimulate one’s curiosity? What stimulates one to pursue a particular line of research? Topics discussed within the context of attempting to address these questions include electrohydrocyclization and electroreductive cyclization, and their application to the total synthesis of natural products, the use of nickel salen and triarylamines as mediators and redox catalysts, the regiospecific rearrangement of cation radicals derived from strained hydrocarbons and the application of the chemistry to the synthesis of a sesquiterpene, and finally, a discussion of the role redox chemistry may play in the expression of the bioactivity of the pseudopterosin class of marine natural products.
Spectroscopic Determination of Optimal Hydration Time of Zircon Surface
Authors: Ordóñez-Regil Eduardo , García-Rosales Genoveva , García-González Nidia
Published: July 2019

When a mineral surface is immersed in an aqueous solution, it develops an electric charge produced by the amphoteric dissociation of hydroxyl groups created by the hydration of the solid surface. This is one influential surface property. The complete hydration process takes a time which is specific for each mineral species. The knowledge of the aqueous solution contact time for complete surface hydration is mandatory for further surface phenomena studies. This study deals with the optimal hydration time of the raw zircon (ZrSiO4) surface comparing the classical potentiometric titrations with a fluorescence spectroscopy technique. The latter is easy and reliable as it demands only one sample batch to determine the optimal time to ensure a total hydration of the zircon surface. The analytical results of neutron activation analysis (NAA) showed the presence of trace quantities of Dy3+, Eu3+ and Er3 in the bulk of zircon. The Dy3+ is structured in the zircon crystalline lattice and undergoes the same chemical reactions as zircon. Furthermore, the Dy3+ has a good fluorescent response whose intensity is enhanced by hydration molecules. The results show that, according to the potentiometric analysis, the hydration process for each batch (at least 8 sample batches) takes around 2 h, while the spectrometric method indicates only 5 min from only one batch. Both methods showed that the zircon surface have a 16h optimal hydration time.
Theoretical Study of the Electronic Effects in the Intramolecular Ketene-Styrene [2+2] Cycloaddition
Authors: Rubio Manuel Fernando , Jiménez-Cruz Federico , Ramírez-Galicia Guillermo
Published: July 2019

DFT (B3LYP/6-31+G*) and post-Hartree-Fock (MP2/6-31+G*//B3LYP/6-31G*) calculations were carried out in order to explain the effect of a remote substituent in the intramolecular ketene-styrene [2+2] cycloaddition of p-substituted 2-methyl-7-arylhepta- 1,6-dien-1-one which produces the bicycle[3.1.1] or the bicycle [3.2.0] heptanones according to Bèlanger experimental results. The transition state geometries were found as an asynchronous process with a three-member ring structure and an incipient positive charge development. Kinetic and thermodynamic controls were proposed at B3LYP/6-31+G* to determine which product is most likely to form in a competence reaction. In addition, the value of the ρ experimental reaction constant was reproduced, ρ ~ -1.34.
N-Ethylbenzylammonium Fluorochromate (VI) Adsorbed on Silica Gel, a Mild and Selective Heterogeneous Reagent
Authors: Sayyed-Alangi S. Zahra , T. Baei Mohammad
Published: July 2019

A mild and selective method for the oxidation of primary and secondary alcohols to their corresponding aldehydes and ketones with N-ethylbenzylammonium fluorochromate (VI), EBAFC, is reported. Stability, reaction rate, ease of work-up and efficiency of the EBAFC are considerably increased upon its adsorption on silica gel. The N-ethylbenzylammonium fluorochromate (VI) adsorbed on silica gel is inert to aldehydes, ketones, oximes, thiols, sulfides, phenols, pyrans, trimethylsilanes, malonates and thioacetamides.
Some possible legal approaches about ‘efficacy’ as research category of alternative methods for conflict solution (AMCS)
Authors: Lezcano Miranda Martha Eugenia , Vásquez-Santamaría Jorge Eduardo
Published: July 2019

By questioning the applicability of Alternative Methods for Conﬂict Solution (AMCS) in public contracts of working, consulting and concession in the Metropolitan Area of Valle de Aburrá in the light of Law 80 of 1993, itwas showed the absence of previous methodological construction on efcacy as analytical category of juridical setting and sociojuridical objects. So it is valid to ask which juridical approaches allow the category ‘efcacy’ tointermediate the object of some juridical research? This work is centered  in showing some possible implications of efcacy as category for juridicalresearch, by a theoretical foundation of its methodological development,from contributions of Law General Theory and statements about efcacy  as general principle in the practice of administrative function and public deals. From two proposed dimensions, in the conclusions is stated thatefcacy is a category that allows a particular research approach, resulting both in a defnite searching criterion and in the validation of juridical and sociojuridical objects, such as conﬂict resolution in public contracts.
La protección de los trabajadores migrantes basada en derechos: la respuesta normativa de la OIT
Authors: López Ahumada Eduardo
Published: July 2019

La protección internacional de las migraciones ha adquirido una mayor relevancia ante el aumento de los flujos migratorios laborales. Este proceso se ha producido debido al desarrollo de la globalización económica y a la ausencia de posibilidades de empleo en los países de origen. El presente trabajo analiza la respuesta normativa de la OIT y los principales obstáculos que su aplicación presenta en el contexto internacional. La respuesta tradicional a dicho fenómeno se ha producido en virtud de los Convenios de la OIT. Estas disposiciones normativas se aplican con carácter general a todos los trabajadores y su efecto jurídico expansivo incluye, ineludiblemente, a los trabajadores migrantes. Se trata, sin duda, de convenios estrechamente relacionados con el trabajo de las personas migrantes, que nos obliga a realizar un análisis transversal y sistemático de una regulación ciertamente dispersa. La situación de especial vulnerabilidad de los trabajadores migrantes nos tiene que hacer reflexionar sobre las situaciones de explotación y de precariedad laboral presentes en la realidad actual.
Teknologi pembenihan ikan gabus (Channa striata)
Authors: Muslim Muslim
Published: July 2019

Ikan gabus (Channa striata) merupakan salah satu jenis ikan air tawar yang bernilai ekonomis tinggi. Potensi biologi ikan gabus yang tahan terhadap kondisi perairan yang kurang baik merupakan peluang untuk dikembangkan menjadi komoditi budidaya perikanan. Selain potensi biologi yang baik, ikan ini juga memiliki potensi bisnis yang sangat menjanjikan. Ikan ini selain dijadikan lauk pauk dalam bentuk segar, banyak produk olahan pangan menggunakan ikan gabus sebagai bahan baku olahan. Sekarang ikan gabus juga dijadikan bahan baku farmasi, karena kandungan albuminnya yang tinggi. Dengan keunggulan aspek biologi dan ekonomi, pembenihan ikan gabus memiliki prospek untuk menghasilkan benih yang akan digunakan untuk restoking sebagai upaya meningkatkan populasi ikan gabus di alam dan juga benih untuk kegiatan budidaya.
PERFORMA HEMATOLOGI IKAN TENGADAK (Barbonymus schwanenfeldii) YANG DIPELIHARA PADA BERBAGAI LEVEL AERASI AIR
Authors: Dewantoro Eko
Published: July 2019

Ikan tengadak termasuk ikan air tawar yang memiliki prospek cerah sebagai komoditas akuakultur, namun informasi tentang karakter fisiologisnya belum banyak diketahui. Penelitian ini bertujuan untuk menganalisis level aerasi yang terbaik bagi kehidupan benih ikan tengadak berdasarkan performa haematologinya. Rancangan yang digunakan pada penelitian ini adalah Rancangan Acak Lengkap (RAL), sebagai perlakuan adalah level aerasi, yaitu 2 L, 6 L, 10 L dan 14 L/menit/40 L air. Peubah yang diamati terdiri dari peubah kualitas air (suhu, total alkalinitas, kejenuhan oksigen, dan total amonia nitrogen) dan performa hematologi (hemoglobin, eritrosit, hematokrit dan kadar glukosa darah). Hasil penelitian menunjukkan bahwa kejenuhan oksigen semakin tinggi dengan meningkatnya level aerasi, yaitu dari rata-rata 86,19% jenuh (aerasi 2 L/menit/40 L air) menjadi 106,51% jenuh (pada aerasi 14 L/menit/40 L air). Suhu dan total alkalinitas air berada pada kisaran optimal, serta total amonia nitrogen (TAN) masih dapat ditoleransi oleh ikan. Aerasi 6 L, 10 L dan 14 L/menit/40 L air menghasilkan kadar hemoglobin lebih tinggi dan glukosa darah yang lebih rendah dari pada aerasi 2 L/menit/40 L air. Sedangkan untuk hematokrit, nilai tertinggi diperoleh pada aerasi 6 L dan 10 L/menit/40 L air
Pemanfaatan Ekstrak Daun Kersen (Muntingia calabura L) untuk Menghambat Pertumbuhan Bakteri Edwardsiella tarda
Authors: Zebua Ratna Dewi , Syawal Henni , Lukistyowati Iesje
Published: July 2019

Penelitian telah dilaksanakan pada bulan Juli sampai dengan Oktober 2018. Penelitian ini bertujuan mengetahui bahan bioaktif yang terkandung di dalam ekstrak daun kersen (Muntingia calabura L), sensitivitas ekstrak daun kersen menghambat pertumbuhan bakteri Edwardsiella tarda, dosis Minimum Inhibitory Concentration (MIC) ekstrak daun kersen yang dapat menghambat pertumbuhan bakteri E. tarda dan  Lethal dosis50ekstrak daun kersen terhadap ikan lele dumbo (Clarias gariepinus) berukuran 7-9 cm.Daun kersen diekstraksi menggunakan metode maserasi dengan pelarut metanol.Dosis ekstrak daun kersen yang digunakan adalah 10000 ppm, 9000 ppm, 8000 ppm, 7000 ppm, 6000 ppm, 5000 ppm, 4000 ppm, 3000 ppm, 2000 ppm, 1000 ppm dan Novobiocin sebagai kontrol. Hasil uji fitokimia ekstrak daun kersen adalah terpenoid/steroid,flavonoid, fenolik, dan saponin. Hasil uji kromatografi lapis tipis dengan nilai Rf terpenoid/steroid 0,88 cm, flavonoid 0,6 cm, dan fenolik 0,6 cm. Ekstrak daun kersen mampu menghambat pertumbuhan E. tarda hingga dosis 700 ppm dengan rata-rata zona hambat 6,14 mm, Minimum Inhibitory Concentration (MIC) ekstrak daun kersen adalah 700 ppm dengan rerata jumlah koloni 261,66 CFU/mL. Hasil uji toksisitas LD50 ekstrak daun kersen terhadap ikan lele dumbo (Clarias gariepinus) dengan metode perendaman adalah pada dosis 720,06 ppm.Kata kunci : Ekstrak Daun Kersen, Edwardsiella tarda, antibakteri, LD50
PENGARUH PENAMBAHAN MADU PADA PENGENCERAN SPERMA TERHADAP MOTILITAS SPERMATOZOA IKAN BAUNG (Mystus nemurus)
Authors: Urabi Debby , Farida Farida , Lestari Tuti Puji
Published: July 2019

Penelitian ini bertujuan untuk mempelajari pengaruh penambahan madu pada pengenceran sperma terhadap motilitas spermatozoa ikan baung. Rancangan yang digunakan adalah Rancangan Acak Lengkap (RAL) dengan 4 perlakuan dan 3 ulangan. Perlakuan campuran larutan madu dan NaCl yang digunakan adalah perlakuan A (0 ml madu dalam 100 ml NaCl), perlakuan B (0,3 ml madu dalam 99,7 ml NaCl), perlakuan C (0,6 ml madu dalam 99,4 ml NaCl) dan perlakuan D (0,9 ml madu dalam 99,1 ml NaCl) Hasil penelitian mengenai penambahan madu dalam pengenceran sperma terhadap motilitas spermatozoa ikan baung memberikan hasil terbaik pada perlakuan D dengan nilai motilitas individu 75,85% dan motilitas massa dengan skor 3-4 (banyak sperma bergerak cepat dan sangat cepat, yang dicirikan dengan adanya pergerakan ditempat dan pergerakan ekor yang cepat).Kata Kunci ; Madu, sperma, motilitas, fertilisasi, Mystus nemurus
Pelanggaran Prinsip Kerjasama dalam Acara Aiman dan Prabowo
Authors: Astriani Aveny Septi
Published: July 2019

Pelanggaran maksim kadang dilakukan oleh orang untuk suatu tujuan tertentu. Penelitian ini bertujuan untuk mengetahui pelanggaran maksim yang dilakukan oleh Prabowo dalam acara Aiman dan Prabowo. Penelitian ini bersifat kualitatif dengan metode observasi dan teknik simak catat. Data penelitian ini berupa video percakapan yang ditranskrip kemudian dianalisis. Hasil yang diperoleh yaitu terdapat pelanggaran maksim kuantitas dan relevansi yang dilakukan oleh Prabowo. Hal ini dilakukan untuk menjaga kewibawannya di depan publik dan menunjukan kepada masyarakat Indonesia bahwa Prabowo adalah orang yang mempunyai banyak pengetahuan dan pengalaman.
Analisis Bahasa Gaul dalam Novel Ayat Amat Cinta Karya Asma Nadia, Boim Lebon, Fahri Asizah, Birulaut-Taufan E. Prast, LIan Kagura, Rex-Ratno Fadillah
Authors: Wijaya Kurniady , Kartika Pheni Cahya
Published: July 2019

Novel ayat amat cinta karya asma Nadia, Boim Lebon dkk Menampilkan bahasa gaul guna menyesuaikan dengan kondisi peminat nya terutama remaja. Berdasarkan penelitian bahasa telah banyak mengalami pergeseran yang signifikan atas bahasa yang di ciptakan hendaknya dapat menciptakan bahasa gaul yang sewajarnya sehingga tidak mengacaukan komunikasi pendidikan bahasa Indonesia. Proses morfologis ini hanya di batasi pada afiksasi reduplikasi, dan pemendekan kata yang terdapat pada novel ayat amat cinta karya asma Nadia, Boim Lebon dkk. Sebagai data penelitian, data ini berbentuk kosakata bahasa gaul dalam novel ayat amat cinta karya asma Nadia, Boim Lebon dkk. Penelitian ini menggunakan penelitian deskriptif kualitatif. Dengan teknik dasar membaca dan mencatat. Dengan teknik analisis interaktif dengn tahapan reduksi, penyajian, dan penarikan kesimpulan. Berdasarkan hasil penelitian dalam novel ayat amat cinta karya asma Nadia, Boim Lebon dkk tersebut telah banyak mengalami pergeseran yang signifikan pada objek penelitian yang diteliti. Oleh karena hal tersebut, peneliti mengharapkan adanya kesadaran sehingga tidak mengacaukan komunikasi pendidikan terutama bahasa indonesia.
Pengaruh Pendekatan Higher Order Thinking Skill (HOTS) Terhadap Keterampilan Membaca Siswa Kelas X SMK Negeri 3 Kota Sukabumi
Authors: Fazriani Nyova , Supendi Deden Ahmad , Humaira Hera Wahdah
Published: July 2019

Penelitian ini bertujuan untuk mengetahui bagaimana keterampilan membaca siswa setelah menggunakan pendekatan Higher Order Thinking Skill (HOTS). Jenis penelitian ini adalah kuantitatif dan desain penelitian yang digunakan pre experimental design dengan model  the one group pretest-posttest. Populasi penelitian kelas X SMK Negeri 3 Kota Sukabumi dengan sampel penelitian yang digunakan yaitu purposive sampling dan kelas yang dijadikan sampel penelitian yaitu X Jasa Boga I. Instrumen dalam penelitian ini menggunakan soal HOTS bahasa Indonesia pilihan ganda sebanyak 20 butir beserta alasan. Berdasarkan uji prasyarat normalitas dan homogenitas bahwa data hasil penelitian berdistribusi tidak normal dan kedua kelas memiliki varians yang homogen. Diketahui analisis data distribusi prates diperoleh hasil Mean 56.17 sedangkan pascates setelah diberikan stimulus atau perlakuan dengan pendekatan HOTS diperoleh hasil Mean 72.06, maka terdapat peningkatan nillai hasil belajar pascates setelah dilalukan stimulus dengan menerapkan pendekatan HOTS pada pembelajaran. Terdapat perbedaan yang signifikan terhadap hasil belajar siswa, dibuktikan dalam Uji-t diperoleh thitung > ttabel (13.69 > 2.042) dan uji Wilcoxon Sign rank yang menghasilkan nilai (asym.sig. (2-tailed)) adalah 0.000 < 0.05 maka hasil hipotesis H0 ditolak dan H1 diterima. Hal ini dapat disimpulkan bahwa terdapat pengaruh hasil belajar pada kemampuan berpikir siswa pada saat pembelajaran dengan menggunakan pendekatan Higher Order Thinking Skill (HOTS) terhadap keterampilan membaca siswa. Kata kunci: Pendekatan Higher Order Thinking Skill (HOTS), Keterampilan Membaca
Early Mixing in Bilingual Children: A Psycholinguistics View
Authors: Rahayu Dwi Ide
Published: July 2019

Most studies on Bilinguals First Language Acquisition (BFLA) are concerned with giving explanation for language mixing in young bilinguals. It is commonly stated that language mixing in children has to be interpreted as evidence for confusions in the bilingual’s language acquisition, in the sense that the two languages are not acquired separately but start out as a single system. In other words, it is in contrast to adults’ code-switching. In this article, early mixing in bilingual children is explored based on psycholinguistics view. This article will first discuss the language acquisition, then the theories and assumptions on bilingualism in early childhood, and last the early mixing in bilingual children. According to the review of related literature, it can be inferred that from psycholinguistics view, language mixing cannot indicate the bilingual children’s lack of ability to differentiate the two language system. Spontaneous translation employed by the bilingual children shows that bilingual awareness and language differentiation is possible at an early stage. Bilingual infants can do language mixing as an evidence of their meta-linguistic awareness and language differentiation. As language mixing may be a good indicator of bilingual fluency, we can say that children who become bilingual in their early childhood will reach their fluency in the two languages by doing language mixing according to the two languages they have acquired.
The Grammatical Errors in the Translational Text: Indonesian-English Structure
Authors: Aini Nurul
Published: July 2019

This paper discussed the study of English and Indonesian word construction based on grammatical errors. Grammatical errors were analyzed by error analysis. The purpose of this paper wanted to know the kinds of grammatical errors and the factors caused it. The qualitative approach was used in this research as the methodology because this study described the data without analysis statistic. The qualitative descriptive revealed the phenomena of linguistic which found in the translation text. In data collection, the researcher used text translation, Indonesian-English that had translated by the fourth semester of student’s English Department. Moreover, the researcher read deeply and grouped and noted the data to find the valid data. The result of this paper were 11 kinds of grammatical errors, they are: misuse of determiner, omission of determiner, misuse of verb, misuse of auxiliary verb, omission of verb, misuse of preposition, misuse of conjunction, misuse of pronoun, omission of pronoun, misuse of singular noun, and misuse of Noun Phrase (NP). In addition to, this study found the factors of the grammatical errors, they are; first, interference of the first language, namely Indonesian. Second, the difference between Indonesian and English structure was also the factor of the grammatical errors.
Profil Kompetensi Pedagogik dan Profesional Guru Bimbingan dan Konseling SMA di Kota Bandung
Authors: Wardhani Nurnaifah Selvia , Farida Euis , Yudha Eka Sakti
Published: July 2019

PROFIL OF PEDAGOGIC AND PROFESSIONAL COMPETENCIES OF SENIOR HIGH SCHOOL COUNSELORS IN BANDUNG CITY. This study aims to get a profile and description of pedagogic and professional competencies of guidance and counseling teachers (counselor) in Bandung. The research used the quantitative approach with survey methods. The population of this research is 127 counselors of the senior high school in Bandung. The Instrument was the development of Permendiknas No. 27 Tahun 2008 concerning Academic Qualification Standards and Counselor Competencies with ten aspects related to pedagogic and professional competencies. Data analysis techniques in this research are descriptive analysis techniques. The result of the research shows that the profile of counselors is in the competent category but in several aspects need some developed. The result of the research can be used as a need assessment for supervisor in understanding counselors competencies so that it can be used as a basis to provide guidance and counseling services effectively and efficiently.
Цитотоксичность новых производных феруловой кислоты на клетках карциномы толстой кишки человека
Authors: Бахолдина Любовь Алексеевна , Маркова Алина Александровна , Хлебников Андрей Иванович , Севодин Валерий Павлович
Published: July 2019

Синтезированы некоторые сложные эфиры феруловой кислоты и спиртов. Установлено их строение и проведена оценка цитотоксического действия на клетки линии HCT116 (карцинома толстой кишки человека). Все исследуемые синтетические соединения проявили бульшую цитотоксичность, чем феруловая кислота, в отношении клеток НСТ116. Самыми активными оказались бензиловый и фенилэтиловый эфиры феруловой кислоты (IC50 0,0077 и 0,0065 г/л соответственно). Ферулоилолигосахариды, выделенные из пшеничных отрубей, в отношении опухолевых клеток НСТ116 проявили меньшую активность, чем свободная феруловая кислота.
River Water Salinity Impact on Drinking Water Treatment Plant Performance Using Artificial neural network
Authors: Abbas Sabreen Hayder , Khudair Basim Hussein , Jaafar Mahdi Shanshal
Published: July 2019

The river water salinity is a major concern in many countries, and salinity can be expressed as total dissolved solids. So, the water salinity impact of the river is one of the major factors effects of water quality. Tigris river water salinity increase with streamline and time due to the decrease in the river flow and dam construction from neighboring countries. The major objective of this research to developed salinity model to study the change of salinity and its impact on the Al-Karkh, Sharq Dijla, Al-Karama, Al-Wathba, Al-Dora, and Al-Wihda water treatment plant along Tigris River in Baghdad city using artificial neural network model (ANN). The parameter used in a model built is (Turbidity, Ec, T.s, S.s, and TDS in) to predict the salinity TDSout.  Results showed that the effectiveness of the artificial neural network model to predicting the salinity is a good agreement between observed and the predicted value of the TDS, through the determination coefficient of the model is (0.998, 0.966, 0.997, 0.998, 0.996, and 0.996) for Al. Karkh, Sharq Dijla, Al.Karama, Al.Wathba, Al.Dora and Al.Wihda respectively. From this value can be shown that ANN is a successful tool for predicting the nonlinear equation of the salinity under different and complicated environmental case along the river.
Guiro: User-Guided Matrix Reordering Preprint Behrisch2019
Authors: Behrisch Michael , Pfister Hanspeter , Schreck Tobias
Published: July 2019

Matrix representations are one of the main established and empirically proven to be effective visualization techniques for relational (or network) data. However, matrices —similar to node-link diagrams— are most effective if their layout reveals the underlying data topology. Given the many developed algorithms, a practical problem arises: “Which matrix reordering algorithm should I choose for my dataset at hand?” To make matters worse, different reordering algorithms applied to the same dataset may let significantly different visual matrix patterns emerge. This leads to the question of trustworthiness and explainability of these fully automated, often heuristic, black-box processes. We present GUIRO, a Visual Analytics system that helps novices, network analysts, and algorithm designers to open the black-box. Users can investigate the usefulness and expressiveness of 70 accessible matrix reordering algorithms. For network analysts, we introduce a novel model space representation and two interaction techniques for a user-guided reordering of rows or columns, and especially groups thereof (submatrix reordering). These novel techniques contribute to the understanding of the global and local dataset topology. We support algorithm designers by giving them access to 16 reordering quality metrics and visual exploration means for comparing reordering implementations on a row/column permutation level. We evaluated GUIRO in a guided explorative user study with 12 subjects, a case study demonstrating its usefulness in a real-world scenario, and through an expert study gathering feedback on our design decisions. We found that our proposed methods help even inexperienced users to understand matrix patterns and allow a user-guided steering of reordering algorithms. GUIRO helps to increase the transparency of matrix reordering algorithms, thus helping a broad range of users to get a better insight into the complex reordering process, in turn supporting data and reordering algorithm insights.
IT Professionals Job Burnout: Work Exhaustion, Depersonalization, dan Personal Accomplishment
Authors: Mayastuti
Published: July 2019

Lingkungan unik dari pekerja Teknologi Informasi (TI) sangat rentan dalam menciptakan work exhaustion, dimana work exhaustion merupakan komponen konseptual dari Job Burnout. Penelitian sebelumnya pada pekerja TI memiliki fokus utama pada anteseden dari work exhaustion, mengidentifikasi lingkungan kerja TI termasuk pada disonansi emosional, beban kerja yang dirasakan, ambiguitas peran dan konflik, otonomi, dan keadilan dalam pemberian reward. Meskipun work exhaustion merupakan komponen penting dari kondisi lingkungan kerja TI, masih ada dua dimensi job burnout theory yang lain masih belum banyak diulas yaitu depersonalization dan kurangnya perasaan personal accomplishment. Penelitian ini akan memperjelas gambaran dengan memperluas model job burnout di lingkungan pekerja TI. Pengembangan model ini dibangun dengan menambahkan anteseden yang diuji secara empiris melalui survey pendahuluan untuk menentukan besarnya factor loading. Model penelitian dibangun oleh dimensi work exhaustion, depersonalization, personal accomplishment, emotional dissonanse dan job satisfaction. Structured Equation Modeling (SEM) dan Partial Least Square (PLS) digunakan untuk memverifikasi konstruk dan menguji hipotesis. Hasil dari penelitian ini diharapkan dapat memberikan rekomendasi pada manajemen untuk waspada terhadap gejala job burnout khususnya dimensi depersonalization dan personal accomplishment untuk menghindari konsekuensi dari dampak negatif yang tidak diinginkan.
Hubungan Antara Profitabilitas Dengan Nilai Perusahaan Yang Dimoderasi Oleh Corporate Social Responsibility
Authors: Handayani Felizia , Martha Lidya
Published: July 2019

The purpose of this study is to examine the effect of profitability on firm value with corporate social responsibility as a moderating variable on the finance sector companies listed on the Indonesia Stock Exchange. The study population is all finance sector companies listed on the Indonesia Stock Exchange at the end of the observation period, namely 2017. The sampling technique used purposive sampling method and obtained a sample of 24 companies. The data used is secondary data taken from the company's annual report through the official website of the Indonesia Stock Exchange (www.idx.co.id). The test uses multiple linear regression analysis with the SPSS 16 Program tool. Profitability is measured using Return On Asset and Return On Equity, while company value is measured by Price to Book Value and corporate social responsibility is measured by the Corporate Social Responsibility Disclosure Index. The results showed that Return On Asset had a negative and not significant effect on firm value, Return On Equity had a positive and significant effect on firm value, CSR weakened significantly the influence of ROA on firm value, and CSR significantly strengthens the effect of ROE on firm value.