bluuebunny/crossref_metadata_2025 huggingface dataset:
Cardiovascular Effects of Androgen Deprivation Therapy in Prostate Cancer: Contemporary Meta-Analyses
Authors: Hu Jiun-Ruey , Duncan Meredith S. , Morgans Alicia K. , Brown Jonathan D. , Meijers Wouter C. , Freiberg Matthew S. , Salem Joe-Elie , Beckman Joshua A. , Moslehi Javid J.
Published: January 2020

Androgen deprivation therapy is a cornerstone of prostate cancer treatment. Pharmacological androgen deprivation includes gonadotropin-releasing hormone agonism and antagonism, androgen receptor inhibition, and CYP17 (cytochrome P450 17A1) inhibition. Studies in the past decade have raised concerns about the potential for androgen deprivation therapy to increase the risk of adverse cardiovascular events such as myocardial infarction, stroke, and cardiovascular mortality, possibly by exacerbating cardiovascular risk factors. In this review, we summarize existing data on the cardiovascular effects of androgen deprivation therapy. Among the therapies, abiraterone stands out for increasing risk of cardiac events in meta-analyses of both randomized controlled trials and observational studies. We find a divergence between observational studies, which show consistent positive associations between androgen deprivation therapy use and cardiovascular disease, and randomized controlled trials, which do not show these associations reproducibly.
Genetically Determined ABO Blood Group and its Associations With Health and Disease
Authors: Groot Hilde E. , Villegas Sierra Laura E. , Said M. Abdullah , Lipsic Erik , Karper Jacco C. , van der Harst Pim
Published: January 2020

Objective:

To determine the spectrum of phenotypes linked to the ABO blood group system, using genetic determinants of the ABO blood group system.

Approach and Results:

We assessed the risk of 41 health and disease outcomes, and 36 linear traits associated with the ABO blood group system in the UK Biobank cohort. A total of 406 755 unrelated individuals were included in this study. Blood groups A, B, and O were determined based on allele combinations of previously established single-nucleotide polymorphisms rs8176746, rs8176719 in the ABO gene. Group AB was excluded because of its relative small sample size. Overall, 187 387 (46%) were male with a mean (SD) age of 57±8.1 years and a median total exposure of 64 person-years (interquartile range, 57–70). Of 406 755 individuals, 182 621 (44.9%) participants had blood group O, 182 786 (44.9%) had blood group A, and 41 348 (10.2%) had blood group B. ABO blood groups were associated with 11 health and disease outcomes (
P
<2.19×10
−4
). ABO blood groups were primarily associated with cardiovascular outcomes. Compared with individuals with blood group O, blood groups A and B were associated with increased odds of up to 1.56 (95% CI, 1.43–1.69) for thromboembolic events and decreased odds for hypertension (0.94 [95% CI, 0.92–0.97]).

Conclusions:

The ABO blood group system is associated with several parameters of healthy aging and disease development. Knowledge of ABO blood groups might be of interest for more personalized approaches towards health maintenance and the prevention of diseases.
Lineage Tracing Reveals the Dynamic Contribution of Pericytes to the Blood Vessel Remodeling in Pulmonary Hypertension
Authors: Bordenave Jennifer , Tu Ly , Berrebeh Nihel , Thuillet Raphaël , Cumont Amélie , Le Vely Benjamin , Fadel Elie , Nadaud Sophie , Savale Laurent , Humbert Marc , Huertas Alice , Guignabert Christophe
Published: January 2020

Objective:

Excessive accumulation of resident cells within the pulmonary vascular wall represents the hallmark feature of the remodeling occurring in pulmonary arterial hypertension (PAH). Furthermore, we have previously demonstrated that pulmonary arterioles are excessively covered by pericytes in PAH, but this process is not fully understood. The aim of our study was to investigate the dynamic contribution of pericytes in PAH vascular remodeling.

Approach and Results:

In this study, we performed in situ, in vivo, and in vitro experiments. We isolated primary cultures of human pericytes from controls and PAH lung specimens then performed functional studies (cell migration, proliferation, and differentiation). In addition, to follow up pericyte number and fate, a genetic fate-mapping approach was used with an NG2CreER;mT/mG transgenic mice in a model of pulmonary arteriole muscularization occurring during chronic hypoxia. We identified phenotypic and functional abnormalities of PAH pericytes in vitro, as they overexpress CXCR (C-X-C motif chemokine receptor)-7 and TGF (transforming growth factor)-βRII and, thereby, display a higher capacity to migrate, proliferate, and differentiate into smooth muscle-like cells than controls. In an in vivo model of chronic hypoxia, we found an early increase in pericyte number in a CXCL (C-X-C motif chemokine ligand)-12-dependent manner whereas later, from day 7, activation of the canonical TGF-β signaling pathway induces pericytes to differentiate into smooth muscle-like cells.

Conclusions:

Our findings reveal a pivotal role of pulmonary pericytes in PAH and identify CXCR-7 and TGF-βRII as 2 intrinsic abnormalities in these resident progenitor vascular cells that foster the onset and maintenance of PAH structural changes in blood lung vessels.
PIM1 (Moloney Murine Leukemia Provirus Integration Site) Inhibition Decreases the Nonhomologous End-Joining DNA Damage Repair Signaling Pathway in Pulmonary Hypertension
Authors: Lampron Marie-Claude , Vitry Géraldine , Nadeau Valérie , Grobs Yann , Paradis Renée , Samson Nolwenn , Tremblay Ève , Boucherat Olivier , Meloche Jolyane , Bonnet Sébastien , Provencher Steeve , Potus François , Paulin Roxane
Published: January 2020

Objective:

Pulmonary arterial hypertension (PAH) is a fatal disease characterized by the narrowing of pulmonary arteries (PAs). It is now established that this phenotype is associated with enhanced PA smooth muscle cells (PASMCs) proliferation and suppressed apoptosis. This phenotype is sustained in part by the activation of several DNA repair pathways allowing PASMCs to survive despite the unfavorable environmental conditions. PIM1 (Moloney murine leukemia provirus integration site) is an oncoprotein upregulated in PAH and involved in many prosurvival pathways, including DNA repair. The objective of this study was to demonstrate the implication of PIM1 in the DNA damage response and the beneficial effect of its inhibition by pharmacological inhibitors in human PAH-PASMCs and in rat PAH models.

Approach and Results:

We found in vitro that PIM1 inhibition by either SGI-1776, TP-3654, siRNA (silencer RNA) decreased the phosphorylation of its newly identified direct target KU70 (lupus Ku autoantigen protein p70) resulting in the inhibition of double-strand break repair (Comet Assay) by the nonhomologous end-joining as well as reduction of PAH-PASMCs proliferation (Ki67-positive cells) and resistance to apoptosis (Annexin V positive cells) of PAH-PASMCs. In vivo, SGI-1776 and TP-3654 given 3× a week, improved significantly pulmonary hemodynamics (right heart catheterization) and vascular remodeling (Elastica van Gieson) in monocrotaline and Fawn-Hooded rat models of PAH.

Conclusions:

We demonstrated that PIM1 phosphorylates KU70 and initiates DNA repair signaling in PAH-PASMCs and that PIM1 inhibitors represent a therapeutic option for patients with PAH.
OpenCitations, an infrastructure organization for open scholarship
Authors: Peroni Silvio , Shotton David
Published: January 2020

OpenCitations is an infrastructure organization for open scholarship dedicated to the publication of open citation data as Linked Open Data using Semantic Web technologies, thereby providing a disruptive alternative to traditional proprietary citation indexes. Open citation data are valuable for bibliometric analysis, increasing the reproducibility of large-scale analyses by enabling publication of the source data. Following brief introductions to the development and benefits of open scholarship and to Semantic Web technologies, this paper describes OpenCitations and its data sets, tools, services, and activities. These include the OpenCitations Data Model; the SPAR (Semantic Publishing and Referencing) Ontologies; OpenCitations’ open software of generic applicability for searching, browsing, and providing REST APIs over resource description framework (RDF) triplestores; Open Citation Identifiers (OCIs) and the OpenCitations OCI Resolution Service; the OpenCitations Corpus (OCC), a database of open downloadable bibliographic and citation data made available in RDF under a Creative Commons public domain dedication; and the OpenCitations Indexes of open citation data, of which the first and largest is COCI, the OpenCitations Index of Crossref Open DOI-to-DOI Citations, which currently contains over 624 million bibliographic citations and is receiving considerable usage by the scholarly community.
Vasilii Maksimov: Individuality and Collectivism in Pëtr Krestonostsev’s Artel of Artists
Authors: Leigh Allison
Published: January 2020

This essay explores the circumstances which led the Russian painter Vasilii Maksimov to compose an unusual group portrait in the early months of 1864. The work was painted shortly after fourteen students withdrew from the Imperial Academy of Arts in St. Petersburg and formed a cooperative association known as the St. Petersburg Artel of Artists, a commune spearheaded by the painter Ivan Kramskoi. Shortly after these events, Maksimov would join an Artel of artists established by the Academy graduate Pёtr Krestonostsev. Few scholars discuss this Artel but exploring the ways it mirrored collective ideals for artistic practice then prevalent in Paris sheds light on how homosocial networks of support rose to the fore in this historical moment. Maksimov’s 1864 group portrait records the productive conflict that resulted from artists’ desire to work with one another through discourse and collaboration in both eastern and western Europe in the period.
Where is Russia Headed, and What is to Be Done? Anders Åslund’s New Book on Russian Political Economy
Authors: Sokhey Sarah Wilson
Published: January 2020

In Russia’s Crony Capitalism, Åslund focuses on Putin’s political and economic strategy in the 2000s. The book draws on Åslund’s deep expertise on Russian politics, detailing the role of Putin’s close associates and businesspeople in establishing the economic system we see in the 2000s in Russia. While making an important contribution to our understanding of Russian political economy, the book overlooks the important issue of economic inequality and variation across the regions of Russia. Åslund sometimes offers policy recommendations that, while perhaps admirable in principle, are unlikely to be politically feasible in the near term in Russia. Nonetheless, Åslund’s perspective is one of the best informed on Russian politics today and a vital part of the ongoing discussion about how, when, and why the Putin era of Russian politics will continue to work and how it will come to an end.
lncRNA NEF (Neighboring Enhancer of FoxA2) Inhibits Pancreatic Cancer via Regulation Wnt Pathway
Authors: Yu Zeqian , Zhao Susu
Published: January 2020

Aim: The purpose of our work was to research the effects and mechanisms of lncRNA NEF in pancreatic cancer treatment. Methods: Gathering the 35 pairs of clinical sample from pancreatic cancer patients. Evaluating the histopathology by HE staining and lncRNA NEF expression
by ISH assay. The PANC-1 and Hs766T cells were respectively divided into NC, pIRSE2 and pIRSE2-NEF. Measuring cell viability, invasion cell number and wound healing rate by CCK8, transwell and wound healing assay. Evaluating Wnt and β-catenin protein expression by WB assay. Results:
The lncRNA NEF level were significantly down-regulation in pancreatic cancer (P < 0.01). The cell viabilities of pIRSE2-NEF groups were significantly suppressed (P < 0.01); with lncRNA NEF supplement, the invasion cell number and wound healing rate of pIRSE2-NEF groups
were significantly depressed compared with those of NC groups (P < 0.01). Meanwhile, the Wnt and β-catenin proteins levels of pIRSE2-NEF groups were significantly down-regulation (P < 0.01). Conclusion: lncRNA NEF inhibits pancreatic cancer cell biological
activities via regulation Wnt/β-catenin pathway.
Seasonal Asymmetries in the Lag between Insolation and Surface Temperature
Authors: Donohoe Aaron , Dawson Eliza , McMurdie Lynn , Battisti David S. , Rhines Andy
Published: January 2020

We analyze the temporal structure of the climatological seasonal cycle in surface air temperature across the globe. We find that, over large regions of Earth, the seasonal cycle of surface temperature departs from an annual harmonic: the duration of fall and spring differ by as much as 2 months. We characterize this asymmetry by the metric ASYM, defined as the phase lag of the seasonal maximum temperature relative to the summer solstice minus the phase lag of the seasonal minimum temperature relative to winter solstice. We present a global analysis of ASYM from weather station data and atmospheric reanalysis and find that ASYM is well represented in the reanalysis. ASYM generally features positive values over land and negative values over the ocean, indicating that spring has a longer duration over the land domain whereas fall has a longer duration over the ocean. However, ASYM also features more positive values over North America compared to Europe and negative values in the polar regions over ice sheets and sea ice. Understanding the root cause of the climatological ASYM will potentially further our understanding of controls on the seasonal cycle of temperature and its future/past changes. We explore several candidate mechanisms to explain the spatial structure of ASYM including 1) modification of the seasonal cycle of surface solar radiation by the seasonal evolution of cloud thickness, 2) differences in the seasonal cycle of the atmospheric boundary layer depth over ocean and over land, and 3) temperature advection by the seasonally evolving atmospheric circulation.
Skill of Rain–Snow Level Forecasts for Landfalling Atmospheric Rivers: A Multimodel Assessment Using California’s Network of Vertically Profiling Radars
Authors: Henn Brian , Weihs Rachel , Martin Andrew C. , Ralph F. Martin , Osborne Tashiana
Published: January 2020

The partitioning of rain and snow during atmospheric river (AR) storms is a critical factor in flood forecasting, water resources planning, and reservoir operations. Forecasts of atmospheric rain–snow levels from December 2016 to March 2017, a period of active AR landfalls, are evaluated using 19 profiling radars in California. Three forecast model products are assessed: a global forecast model downscaled to 3-km grid spacing, 4-km river forecast center operational forecasts, and 50-km global ensemble reforecasts. Model forecasts of the rain–snow level are compared with observations of rain–snow melting-level brightband heights. Models produce mean bias magnitudes of less than 200 m across a range of forecast lead times. Error magnitudes increase with lead time and are similar between models, averaging 342 m for lead times of 24 h or less and growing to 700–800 m for lead times of greater than 144 h. Observed extremes in the rain–snow level are underestimated, particularly for warmer events, and the magnitude of errors increases with rain–snow level. Storms with high rain–snow levels are correlated with larger observed precipitation rates in Sierra Nevada watersheds. Flood risk increases with rain–snow levels, not only because a greater fraction of the watershed receives rain, but also because warmer storms carry greater water vapor and thus can produce heavier precipitation. The uncertainty of flood forecasts grows nonlinearly with the rain–snow level for these reasons as well. High rain–snow level ARs are a major flood hazard in California and are projected to be more prevalent with climate warming.
Observed Near-Storm Environment Variations across the Southern Cumberland Plateau System in Northeastern Alabama
Authors: Lyza Anthony W. , Murphy Todd A. , Goudeau Barrett T. , Pangle Preston T. , Knupp Kevin R. , Wade Ryan A.
Published: January 2020

The Sand Mountain and Lookout Mountain Plateaus in northeastern Alabama have been established as a regional relative maximum in tornadogenesis reports within the southeastern United States. Investigation of long-term surface datasets has revealed (i) stronger and more backed winds atop Sand Mountain than over the Tennessee Valley, and (ii) measured cloud-base heights are lower to the surface atop Sand Mountain than over the Tennessee Valley. These observations suggest that low-level wind shear and lifting condensation level (LCL) height changes may lead to conditions more favorable for tornadogenesis atop the plateaus than over the Tennessee Valley. However, prior to fall 2016, no intensive observations had been made to further investigate low-level flow or thermodynamic changes in the topography of northeastern Alabama. This paper provides detailed analysis of observations gathered during VORTEX-SE field campaign cases from fall 2016 through spring 2019. These observations indicate that downslope winds form along the northwest edge of Sand Mountain in at least some severe storm environments in northeastern Alabama. Wind profiles gathered across northeastern Alabama indicate that low-level helicity changes can be substantial over small distances across different areas of the topographic system. LCL height changes often scale to changes in land elevation, which can be on the order of 200–300 m across northeastern Alabama.
Where have we been and where are we going? The state of contemporary health promotion
Authors: Woodall James , Freeman Charlotte
Published: January 2020

This paper seeks to critically discuss the current state of health promotion, arguing that ambiguity remains in its conceptual foundation, practice and education, which is contributing to its decline in several parts of the world. Drawing on relevant literature, the paper re-examines the status of health promotion as a specialist discipline in its own right and suggests that the reaffirmation of this status can move health promotion from the margins to the mainstream of public health policy and practice. The paper briefly rehearses some common conceptualisations of health promotion before suggesting four tensions which, if resolved, could offer greater conceptual clarity and galvanise the contribution of the discipline in addressing individual and community health across the globe.
The imaginary constitution of financial crises
Authors: Komporozos-Athanasiou Aris , Fotaki Marianna
Published: January 2020

This article proposes an alternative sociological framework for dealing with the imaginary constitution of financial crises. Theorisation of financial crises is often limited by dualistic juxtaposition of the rational and irrational, moral and immoral, calculative and intuitive, thus neglecting the imaginary structuring of such dyads in the construction of financial and fiscal realities. To address this lacuna, we introduce ideas from philosopher Cornelius Castoriadis, and develop a framework that unpicks the often-suppressed, mediating and generative role of imagination in finance. On the one hand, we show how dominant forms of imagination enable the financialisation of contemporary societies, serving to sustain existing debt practices and lender–debtor relationships. On the other hand, we propose a re-animated ‘sociological imagination’ that offers potential avenues for establishing alternative social visions of the future that will enable re-thinking of the nature of debt, money and financial institutions.
Explaining transit expenses in US urbanised areas: Urban scale, spatial form and fiscal capacity
Authors: Zhao Jerry Zhirong , Lou Shengnan , Fonseca Camila , Feiock Richard , Shen Ruowen
Published: January 2020

This research seeks to explain patterns of capital investment and operating expenses for urban transit systems in the United States. We isolate supply factors including urban scales, urban spatial form and financial capacity. Individual and group transit demands are accounted for by social and demographic characteristics including education level, immigrant populations, poverty levels, senior population and race. The results demonstrate that transit investments are super-linear to population, directly contradicting predictions of Bettencourt’s popular urban scale theory. Transit expenses are explained primarily by urban scales, urban spatial form and financial capacity, but demand forces such as poverty, car usage and political ideology have strong effects as well.
Getting the Picture: A Cross-Cultural Comparison of Chinese and Western Users’ Preferences for Image Types in Manuals for Household Appliances
Authors: Li Qian , de Jong Menno D. T. , Karreman Joyce
Published: January 2020

Research shows that Western and Chinese user instructions use visuals differently. Two basic tendencies may be discerned: Chinese manuals place more emphasis on visuals and their selection of visuals is less strictly confined to usability related functionality. This study investigates whether such cultural differences correspond to user preferences. Three hypotheses were tested: (a) Chinese users value pictures more than Western users; (b) Chinese users appreciate diverting, cartoon-like pictures more than Western users; and (c) Western users appreciate strictly instrumental pictures more than Chinese users. To test these hypotheses, a quasi-experiment ( N = 158) was conducted with cultural background as independent variable and appreciation for pictures as dependent variable. All participants rated 15 pictures, which were presented in the context of user instructions. All three hypotheses were confirmed. Cultural differences regarding the use of visuals should therefore be taken into account when localizing Western manuals for the Chinese market, or vice versa.
Duplicitous Me: Communal Narcissists and Public Service Motivation
Authors: Fennimore Anne K.
Published: January 2020

This article explores communal narcissism and a possible dark side of public service motivation (PSM) in the context of employment sector. Personality psychology insights are offered to further develop PSM theory and practice from multidisciplinary angles. PSM is thought to characterize a public service ethic with public and nonprofit sector employees possessing other-directed, and perhaps communal values, rather than the self-directed, agentic values characterizing private sector organizations. However, PSM’s prosocial bias often discounts self-interested and mixed-motive interests. Unlike agentic narcissism, in which self-aggrandizement is more apparent to others, in communal narcissism, self-aggrandizement is hidden by a “saint-type bias” and self-proclaimed other-orientation. As a result, some communal narcissism traits appear to mimic dimensions of the PSM scale. The results of two studies reveal that communal narcissism positively associates with PSM. In addition, PSM positively relates to the nonprofit sector and mediates indirect, positive relationships between communal narcissism and the nonprofit sector.
Intradiploic Epidermoid of the Tegmen Tympani With Cochlear Invasion
Authors: Yu Cheryl , Kazi Aasif A. , Coelho Daniel H.
Published: January 2020

Intradiploic epidermoid cysts are benign tumors that account for ∼1% of all intracranial space occupying lesions. Because of the indolent growth, symptoms are usually gradual in onset with a prolonged duration. While they can originate from any part of the skull, temporal bone epidermoids are rare. We describe a case of an unusual presentation of a temporal bone epidermoid cyst. A 64-year-old male presented with sudden right-sided hearing loss and worsening right eyelid ptosis was found to have a nonenhancing lobulated mass above the right tegmen tympani with complex signal and possible communication with the apical turn of the cochlea on magnetic resonance imaging (MRI). He underwent subtemporal craniotomy with excision of the cyst lining and matrix without any complications and was discharged home on postoperative day 1. Complete excision was not possible given that the facial nerve and cochlea were improved. He had subjective improvement in his hearing immediately after surgery. Intradiploic epidermoid cysts are benign tumors that can present anywhere in the skull with variable presentation. While complete excision is the goal, neurovascular involvement may make this challenging. The use of computed tomography scan and MRI can prove to be invaluable in determining accurate diagnosis and size for surgical planning.
Refining domestic politics theories of IPE: A societal approach to governmental preferences
Authors: Schirm Stefan A
Published: January 2020

Domestic politics theories of international political economy and the recent disruptions in international cooperation and trade apparently induced by domestic discontent have shown the crucial role domestic forces play in influencing governmental preferences. This article contributes to this theoretical school, first, by assessing seminal works on the ideational, material, and institutional dimensions of domestic politics, and second, by conceptualising the ‘societal approach’ to fill a major gap in domestic politics theorising. The societal approach asks under which conditions value-based societal ideas, domestic institutions, and material interests matter in shaping governmental preferences. When do ideas prevail over interests and vice versa? How do they interact with each other and with domestic institutions? The societal approach includes all three domestic variables as potential driving forces for governmental preferences and conceives them both as individual and as interacting forces. Most importantly, it complements domestic politics theories by proposing hypotheses on the conditions for the influence of each variable on governmental preferences. The article brings together previously conceived parts of the societal approach and considerably expands it.
Chemical Frost Protection of Road Surfaces: A Laboratory Investigation
Authors: Fjærestad Janne Siren , Klein-Paste Alex , Wåhlin Johan
Published: January 2020

Anti-icing chemicals are commonly used to protect against hoar frost formation on roadways and bridges. Because of their negative impact on both environment and infrastructure, their use should be optimized. During conditions for hoar frost formation, this means that good knowledge is needed about when it is necessary to apply chemicals, and the corresponding protection time. A laboratory setup has been used to study the freezing process for a salted road surface during conditions for hoar frost formation, and a description of the process is given. It has been observed that freezing starts in the top layer of the applied solution, indicating the occurrence of a concentration gradient owing to accumulation of water molecules in the top layer. A British pendulum was used to simulate the mechanical load of traffic. The pendulum successfully destroyed the ice up to a certain ice fraction. This ice fraction was seen to depend on the amount of salt solution applied to the test sample. Finally, it has been illustrated how the maximum ice fraction can be used to calculate the amount of water allowed to be added to the road surface, and estimates of the protection time are given.
Cluster Based Methodology for Scheduling a University Shuttle System
Authors: Mahmoudzadeh Ahmadreza , Wang Xiubin Bruce
Published: January 2020

A university transit service owns and operates a shuttle fleet that serves thousands of students that reside on and around the campus within a fairly compact area as a special form of public transit. Usually, there is a central drop off point in the center of the campus. Each shuttle goes on a tour that covers a certain area where apartment complexes housing the students are located. The main goal of this study is to find a practical scheduling methodology for the university shuttle fleet considering students’ travel behaviors and class times. The 2018–2019 annual ridership data of Texas A&M University (TAMU) shuttle system is used to identify distinct travel patterns in weekday and weekend services. A clustering method is proposed to develop homogenous departure times within the current schedules respectively for on- and off-campus routes by taking the high student loads and graduate/undergraduate behaviors into account. A new scheduling method is developed to update the current shuttle departure times by leaning on a generous/highly frequent system usage. This easy to use method considers the dynamics of daily activities conveniently. Results of the developed new schedules for on-campus and off-campus routes show that the current university shuttle fleet could operate more efficiently during the time when class changes take place. This new methodology could potentially increase the efficiency of the system in relation to total shuttle runs by up to 25%.
Occupational Competitiveness Analysis of the U.S. Transportation and Logistics Cluster
Authors: Kumar Indraneel , Beaulieu Lionel J. , Zhalnin Andrey , Song Chun
Published: January 2020

This paper explores occupational or human capital attributes of transportation and logistics clusters in the U.S., by analyzing logistics clusters, such as Memphis and uncovers the differences in occupations or knowledge and skill contents of the workforce. The research builds on previous studies funded by the U.S. Economic Development Administration on U.S. occupation clusters providing insights on logistics clusters from a human capital perspective. The study draws specifically from the industry-and-occupation cluster crosswalks building on previous research on occupation cluster industry cluster-location quotient (OCIC-LQ), and recent research on computerization and automation of occupations. The research questions include how knowledge occupation clusters differ in specialization within the select logistics clusters. How can occupation clusters inform the traditional cluster-based economic development policies in the U.S.? How might automation impact the logistics cluster? The findings show that transportation and logistics clusters are unique in knowledge-based occupations with some commonalities found in different locations. Based on occupational and staffing patterns, nearly 71% of occupations or tasks and activities within the transportation and logistics cluster in Memphis is at risk of automation. The research builds a case for place-based cluster development and people-based workforce development for transportation and logistics cluster in the U.S.
Two-Community Noisy Kuramoto Model Suggests Mechanism for Splitting in the Suprachiasmatic Nucleus
Authors: Rohling Jos H. T. , Meylahn Janusz M.
Published: January 2020

Recent mathematical results for the noisy Kuramoto model on a 2-community network may explain some phenomena observed in the functioning of the suprachiasmatic nucleus (SCN). Specifically, these findings might explain the types of transitions to a state of the SCN in which 2 components are dissociated in phase, for example, in phase splitting. In contrast to previous studies, which required additional time-delayed coupling or large variation in the coupling strengths and other variations in the 2-community model to exhibit the phase-split state, this model requires only the 2-community structure of the SCN to be present. Our model shows that a change in the communication strengths within and between the communities due to external conditions, which changes the excitation-inhibition (E/I) balance of the SCN, may result in the SCN entering an unstable state. With this altered E/I balance, the SCN would try to find a new stable state, which might in some circumstances be the split state. This shows that the 2-community noisy Kuramoto model can help understand the mechanisms of the SCN and explain differences in behavior based on actual E/I balance.
Fat-Containing Lesions of the Liver: A Review of Differential Diagnoses
Authors: Chung Andrew D.
Published: January 2020

The presence of intralesional fat provides an invaluable tool for narrowing the differential diagnosis for both benign and malignant neoplasms of the abdomen and pelvis. The ability to characterize intralesional fat is further expanded by the ability of magnetic resonance imaging to detect small quantities (intravoxel) of fat. The differential diagnosis of fat-containing lesions arising in the liver is broader than that of many other solid organs. However, this differential can be further refined depending on the type of fat (macroscopic vs intravoxel) and with the use of ancillary imaging findings. Radiologists must be aware of benign and malignant mimickers of common lesions.
Whole-Body Diffusion-Weighted MRI Compared to 18 FFDG PET/CT in Initial Staging and Therapy Response Assessment of Hodgkin Lymphoma in Pediatric Patients
Authors: Shapira-Zaltsberg Gali , Wilson Nagwa , Trejo Perez Esther , Abbott Lesleigh , Dinning Stephen , Kapoor Cassandra , Davila Jorge , Smith Barry , Miller Elka
Published: January 2020

Purpose:

The aim of our study was to compare whole-body diffusion-weighted MRI (WB-DWI-MRI) to fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in the assessment of initial staging and treatment response in pediatric patients with Hodgkin lymphoma.

Materials and Methods:

This prospective study comprised 11 children with Hodgkin lymphoma. Whole-body DWI-MRI and FDG-PET/CT were obtained at baseline and after 2 cycles of chemotherapy. Two radiologists measured the apparent diffusion coefficient (ADC) values of the sites of involvement agreed upon in consensus and 1 nuclear medicine physician assessed the PET/CT. Reliability of radiologists’ ratings was assessed by intraclass correlation coefficients (ICC2,1). The sensitivity and positive predictive value (PPV) of DW-MRI relative to PET/CT were calculated for nodal and extranodal sites. The patients were staged according to both modalities. Association of treatment responses was assessed through the Pearson correlation between the ADC ratios and the change standardized uptake value (SUV) between baseline and follow-up.

Results:

There was good agreement between the raters for nodal and extranodal ADC measurements. The sensitivity and PPV of DW-MRI relative to PET/CT of nodal disease was 0.651 and 1.0, respectively, at baseline, and 0.697 and 0.885 at follow-up. The sensitivity and PPV of extranodal disease were 0.545 and 0.6 at baseline, and 0.167 and 0.333 at follow-up. Diffusion-weighted MRI determined correct tumor stage in 8 of 11 examinations. There was poor correlation between the ADC ratios and the absolute change in SUV between baseline and follow-up (0.348).

Conclusion:

Our experience showed that WB-DWI-MRI is inferior to PET/CT for initial staging and assessment of treatment response of Hodgkin lymphoma in pediatric patients.
Solidarity at Work: Concepts, Levels and Challenges
Authors: Morgan Glenn , Pulignano Valeria
Published: January 2020

Solidarity is not a unified phenomenon with unchanging qualities; it partakes of moral, political and performative elements that are underpinned and reinforced by a shared work context, an organisational infrastructure and an institutional frame which together create distinctive path dependencies in solidarity across different forms of capitalism. Neo-liberalism has challenged these path dependencies by changing the material conditions and the ideological terrain, by heightening the diversity of the workforce, by restructuring the institutional context. However, this is not the end of solidarity and the article addresses the question of what sort of solidarities are now emerging and how.
The Moral Economy of Solidarity: A Longitudinal Study of Special Needs Teachers
Authors: Bolton Sharon C , Laaser Knut
Published: January 2020

Based on a longitudinal study of a Pupil Referral Unit (PRU) in England for children excluded from mainstream schools and utilising a moral economy lens, this article explores how solidarity is created and maintained in a very particular community of teachers and learning support assistants (LSAs). A moral economy approach highlights the centrality of people’s moral norms and values for understanding the multi-layered dimensions of solidarity in organisations and how it changes in the context of transformations in the labour process. The article illustrates how teachers and LSAs rely on mutuality, underpinned by moral norms of justice, and values of care, dignity and recognition, to cope with physically and emotionally demanding work that is under-resourced and undervalued. The analysis reveals that solidarity is not only against unjust workplace regimes, but also for connectivity and a humanised labour process.
Etiology, clinical, and epidemiological characteristics of severe respiratory infection in people living with HIV
Authors: Pecego AC , Amâncio RT , Costa DM , Bozza FA , Siqueira MM , Oliveira ML , Cerbino-Neto J , Japiassu A
Published: January 2020

People living with HIV (PLWH) are more prone to severe respiratory infections. We used the severe acute respiratory infection (SARI) definition to describe the etiology, clinical, and epidemiological characteristics in this population. This was a prospective observational study including PLWH hospitalized with fever and cough. Those with symptom onset up to 10 days were classified as severe acute respiratory infection and 11–30 days as non-severe acute respiratory infection. Blood, urine samples and nasopharyngeal swabs were collected. Data were extracted from patient charts during their hospital stay. Forty-nine patients were included, median CD4 cell count: 80 cells/mm3, median time since HIV diagnosis and hospital admission: 84 months and 80% were antiretroviral therapy exposed. Twenty-seven patients were classified as SARI. Etiology was identified in 69%, 47% were polymicrobial. Respiratory virus (9 SARI vs. 13 non-SARI), bacteria (5 SARI vs. 4 non-SARI), Mycobacterium tuberculosis (6 SARI group vs. 7 non-SARI group), Pneumocystis jirovecii (4 SARI vs. 1 non-SARI), Cryptococcus neoformans (1 SARI vs. 3 non-SARI), and influenza A (1 SARI vs. 2 non-SARI). Dyspnea was statistically more prevalent in SARI (78% vs. 36%, p = 0.011) but the risk of death was higher in the non-SARI (4% vs. 36%, p = 0.0067). In the severely immunocompromised PLWH, severe acute respiratory infection can be caused by multiple pathogens and codetection is a common feature.
Surveying testing preferences in Black, Latin American, and other minorities for the co-design of digital vending machines for HIV self-testing
Authors: Lee Ming J , Onyango Denis , Hamza Husseina , Phiri Elias , Furlong Tony , Goel Priyanka , Edwardes Dominic , Tweed Marc , Guerra Luis , Hamzah Lisa , Dean Gillian , Fox Julie , Vera Jaime H
Published: January 2020

The use of digital vending machines (VMs) to delivery HIV self-testing (HIVST) could expand HIV testing in priority populations. We surveyed primarily Black African (BA) participants and other minority ethnicities, to identify acceptability, preferences, and concerns of using VMs for HIVST dispensing. A structured survey was developed with Black African and Caribbean, Latin American and other Minorities (BLAM) communities, and distributed between September 2018 and January 2019. Participants were recruited using mobile tablet surveys distributed by outreach volunteers, and online through BLAM communities’ websites, workshops, and language-specific messages on social media. Descriptive analyses were undertaken stratified by ethnic groups. One hundred and twenty-eight (67.0%) participants identified as BAs, 31 (16.2%) Black Caribbeans (BCs), 22 (11.5%) Latin Americans (LAs), and 10 (5.2%) other non-white ethnicities (ONWEs). Rates of willingness to use the HIVST were high in all groups except BCs (BAs 77.9%, BCs 53.6%, LAs 81.8%, ONWEs 80.0%). Most participants favoured healthcare-associated venues for VM placement, but there were differences in community venues favoured by different ethnic groups and concerns reported. HIVST is acceptable in many BLAM communities and increases understanding of the concerns and how to address them in the design of VMs for HIVST, to expand HIV testing in these priority communities.
Toxicity effects of Nerium oleander, basic and clinical evidence: A comprehensive review
Authors: Farkhondeh T , Kianmehr M , Kazemi T , Samarghandian S , Khazdair MR
Published: January 2020

Introduction:

Nerium oleander is a plant that is frequently grown in gardens and public areas. N. oleander is distributed originally in subtropical Asia but is now growing in many parts of the world, such as the United States, Australia, China, and Middle East countries. Pharmacological effects of plant including antinociceptive, anti-inflammatory, and anticancer activity were reported, but the potential toxic effects of all parts of the shrub either fresh or dried on animal and human body were documented.

Method:

The data of this review article were obtained from Medline/Pubmed, Scopusand Google Scholar databases in English until September 2019. To include all publications in this field, keywords such as N. oleander and toxicity were used.

Results:

The poisoning effects of plant or their active alkaloids induced infiltration of cells with hemorrhage and sever negative changes in the lung, induce lesions, and infiltration of inflammatory cells into the portal spaces with scattered necrosis of hepatocytes in the liver, cardiac toxicity of the plant in the heart were included, induced varying degrees of hemorrhage, myocardial degeneration, and necrosis. It also induced arrhythmia, sinus bradycardia, and prolonged P-R interval in electrocardiographic records.

Conclusions:

The toxic effects of N. oleander are mostly related to its inhibitory effects on the Na+-K+ ATPase pump in the cellular membrane. However, the exact molecular mechanism involved in the toxicity of N. oleander is not clear.
A curvilinear bivariate random changepoint model to assess temporal order of markers
Authors: Segalas Corentin , Helmer Catherine , Jacqmin-Gadda Hélène
Published: January 2020

In biomedical research, various longitudinal markers measuring different quantities are often collected over time. For example, repeated measures of psychometric scores are very informative about the degradation process toward dementia. These trajectories are generally nonlinear with an acceleration of the decline a few years before the diagnosis and a large heterogeneity between psychometric tests depending on the underlying cognitive function to be evaluated and the metrological properties of the test. Comparing the times of acceleration of the decline before diagnosis between cognitive tests is useful to better understand the natural history of the disease. Our objective is to propose a bivariate random changepoint model that allows for the comparison of the mean time of change between two markers. A frequentist approach is proposed that gives validated statistical tests to assess the temporal order of the changepoints. Using a spline transformation function, the model is designed to handle non-Gaussian data, that are common for cognitive scores which frequently exhibit a strong ceiling effect. The procedure is assessed through a simulation study and applied to a French cohort of elderly to identify the order of the decline of several cognitive scores. The whole methodology has been implemented in a R package freely available.
The experts’ perspective of “ask-an-expert”: An interview-based study of online nutrition and vaccination outreach
Authors: Sharon Aviv J. , Baram-Tsabari Ayelet
Published: January 2020

Social media allow experts to form communities and engage in direct dialogue with publics, which can promote mutual understanding between sciences and publics. However, little is known about experts’ participation in online communities, or effective ways to prepare them for public engagement. Here, we explored these issues with experts who voluntarily engage with publics on social media, to understand their public engagement practices. Stimulated recall interviews were conducted with 20 experts who participate in question-and-answer Facebook groups dedicated to vaccines and nutrition. The findings suggest that experts employ diverse considerations in their outreach, partly to establish epistemic trustworthiness. These can be grouped into three goals and two constraints: countering misinformation, establishing benevolence, and establishing competence while maintaining integrity and clarity. Empathic failure and burnout both emerged as factors that impair establishing benevolence. We discuss implications for community-level science literacy and for preparing scientists for “bounded engagement with publics.”
Evaluation of aroma styles in flue-cured tobacco by near infrared spectroscopy combined with chemometric algorithms
Authors: Liao Fu , Li Yongsheng , He Wenmiao , Tie Jinxin , Hao Xianwei , Tian Yunong , Li Shitou , Zhang Lili , Tang Liang , Wu Jizhong , Wang Hui , Xu Qingquan , Bi Yiming
Published: January 2020

Aroma style is a complex but critical sensory indicator of flue-cured tobacco. Near infrared spectroscopy was used to investigate the aroma style of flue-cured tobacco. A model screening-sensory validation strategy is herein proposed to overcome obstacles such as the subjectivity of sensory evaluation. Samples with exemplary styles and consistent opinion from a panel were selected as typical samples. Only typical samples were used for modeling. Other samples (atypical samples) were predicted through the proposed model. With references to sensory evaluation, the predictive accuracy reached to 100 and 79.0% for typical and atypical samples, respectively. This method provided a new perspective to evaluate the aroma styles of flue-cured tobacco by a combination of sensory evaluation and chemical analysis.
Request for an Andexxa Value Analysis
Authors: Yin Ellen , McConnell Karen J.
Published: January 2020

This perspective is a formal request to the American College of Cardiology and American Heart Association (ACC/AHA) to perform a value analysis on andexanet (Andexxa) similar to what was completed for the PCSK9 inhibitors in the 2018 ACC/AHA Blood Cholesterol guidelines. Based on the safety and efficacy concerns of andexanet alfa, a value statement in and or as an addendum to society guidelines is vital considering the high cost of therapy. In this era of ever-increasing health care costs, every clinician, health system, national society, insurer, and pharmaceutical company should work to be good stewards of our society’s resources.
Borderless Media: Rethinking International Marketing
Authors: Sheth Jagdish N.
Published: January 2020

This article focuses on the impact of digital platforms on international marketing. It describes the evolution of social media and its influence on marketing. After identifying a typology of context for international marketing, the author identifies and describes five dimensions of value creation in marketing: access, affordability, acceptance, awareness, and activation. Finally, this article provides future implications for areas of research in social media and international marketing.