bluuebunny/crossref_metadata_2025 huggingface dataset:
موقف تورغوت أوزال ورجب طيب أردوغان تجاه الاسلام والديمقراطية 1983- 2007: دراسة مقاربة
Authors: أ.م.د. منال محمد  الصالح
Published: January 2025

تسعى تركيا على الدوام لتكون زعيمة سياسية في المنطقة وأن تندرج ضمن أكبر عشرة اقتصاديات في العالم وتبدو تلك الخطط الطموحة لقيادة البلاد في المرحلة الحالية ممكنة التنفيذ نتيجة سياسة تورغوتأوزال أثناء وجوده في السلطة في حقبة الثمانينيات والتسعينيات من القرن الماضي والتي هدفت لتحقيق استقرار البلاد والانفتاح على العالم وبالرغم من النجاحات الأولية الملموسة إلا أن الأنشطة التي تم تنفيذها خلال تلك المدة أسفرت عن نتائج متناقضة وذلك بسبب مشكلات اقتصادية وسياسية مما تسبب في العودة إلى الاضطرابات السياسية بعد وفاة أوزال في عام 1993 وانزلقت البلاد مرة أخرى إلى سلسلة من فضائح الفساد أطاحت بحكومات ائتلافية ضعيفة واحدة تلو الأخرى. وبلغ هذا الاضطراب السياسي ذروته في الانقلاب العسكري عام 1997 ومن المفارقة أن الإرث الأكثر نجاحًا وقابلية التطبيق لتلك الاصلاحات كانت السبب في وصول حزب العدالة والتنمية برئاسة رجب طيب أردوغان إلى السلطة في عام 2002 بعد فوزه في الانتخابات فأحدث تحولا جذريا في المشهد السياسي ،واصل حزب العدالة والتنمية في السنوات الأولى حكمه بنشاط وتعميق لإصلاحات أوزال النيوليبرالية وخلق الظروف الأكثر ملائمة لرأس المال الأجنبي والتركي للاستثمار فيها. وفي العقد الأول من القرن الحادي والعشرين بدأ أردوغان وقادة الحزب في الابتعاد باستمرار عن مبادئهم النيوليبرالية السابقة.
Karyological Examination of Ornithogalum orthophyllum Ten. and Ornithogalum oligophyllum E. D. Clarke
Authors: Kıran Yaşar , Öğer Sibel , Doğan Gülden
Published: January 2025

In this study, two species of Ornithogalum L. genus (Ornithogalum orthophyllum Ten. and Ornithogalum oligophyllum E. D. Clarke), one of the important genus of the Asparagaceae family, were examined in terms of karyological aspects. The plant materials used in the study were collected from the natural distribution areas of the plants around Elazığ 2019. Some of the collected samples were turned into herbarium samples and stocked in the FU herbarium. Bulbs obtained from the collected samples were used in cytotaxonomic studies. As a result of the studies carried out in dividing somatic cells, chromosome counts and karyotype analyzes of the species were made and their ideograms were drawn. Chromosome number were determined as 2n=20 and karyotype formula M+3m+3sm+3st in Ornithogalum oligophyllum, Ornithogalum orthophyllum species as 2n=14 and karyotype formula as 3m+2sm+2st.
Contributions to the Woody Plants Flora of Şanlıurfa (Türkiye)
Authors: Aslan Mehmet , Akan Hasan
Published: January 2025

This study material consists of woody plants naturally growing in Şanlıurfa province. Within the scope of this study carried out between 2014 and 2017, all natural growth areas within the borders of Şanlıurfa province were visited and 19 genera and 24 taxa belonging to 13 families were identified in these areas. The most frequently identified natural woody plants are Pistacia khinjuk (Bıttım), Pistacia terebinthus subsp. palaestina (Wild Pistachio), Rhus coriaria (Sumac), Quercus brantii (Persian Acorn Oak), Ficus carica subsp. carica (Fig), Punica granatum (Pomegranate), Amygdalus communis (Almond), Rosa canina (Rosehip) and Cerasus mahaleb (Mahaleb).
Rosuvastatin accelerates the healing process of partial-thickness burn wounds in rats by reducing TNF-α levels
Authors: Marneri Alexandra , Mulita Francesk , Leivaditis Vasileios , Kotoulas Serafeim – Chrysovalantis , Gkoutziotis Ioannis , Kalliopi Stavrati , Tasios Konstantinos , Tchabashvili Levan , Michalopoulos Nikolaos , Mpallas Konstantinos
Published: January 2025

Introduction

Burn wound healing is a complex, dynamic process that involves a coordinated cascade of cellular responses and phases. Inflammation, proliferation and remodeling are the main phases of tissue repair, while tumor necrosis factor α (TNF-α) and procalcitonin (PCT) seem to be important mediators affecting the inflammatory state. Our aim was to assess the effect of rosuvastatin on tissue repair after partial thickness burn injury in healthy animals.

Material and methods

In this randomized prospective experimental study, 36 male rats were randomly divided into two groups: placebo-treated (PG) and topical rosuvastatin-treated (SG). Under anesthesia, a partial-thickness burn trauma was induced in the dorsal region of the rats using an iron seal. Tissue samples were collected for histopathological examination as well.

Results

Variables of TNF-α, procalcitonin and macroscopic assessment were normally distributed between the two groups on all studied days. The expression of TNF-α was found to be lower in burn injuries treated with topical rosuvastatin in comparison with placebo-treated animals on days 3, 6 and 9. PCT values in rosuvastatin-treated subgroups were statistically significantly lower than in placebo subgroups. Upon macroscopic examination, a significantly smaller burnt area in the statin-treated group was detected compared to the non-statin group on all days, except for day 3. Histopathological examination demonstrated higher levels of mean neutrophil infiltration in the placebo group (day 3). Finally, fibroblast proliferation, angiogenesis and re-epithelization levels were noted to be higher after the topical application of rosuvastatin.

Conclusions

Rosuvastatin accelerated wound healing and down-regulated TNF-α and PCT levels.
Sociologia, progresso e caminho civilizatório na Argentina: um percurso sobre as ideias de mudança social no longo prazo (1845-1960)
Authors: Pereyra Diego Ezequiel
Published: January 2025

Ao longo do tempo, a sociologia argentina configurou um projeto intelectual que buscou reconciliar a promessa mítica de um futuro promissor para o país com um programa político orientado para a mudança social. Nesse sentido, essa disciplina concentrou-se na tentativa de compreender a história do desenvolvimento civilizatório da nação argentina. Quando, em meados do século XIX, expandiu-se um legado cultural que afirmava um destino manifesto de grandeza, a sociologia assumiu a tarefa de rastrear e orientar essa trajetória rumo à civilização, adaptando todo o seu arsenal teórico-cultural para cumprir esse objetivo. No entanto, as crises permanentes na Argentina levaram a sociologia local a refletir sobre os obstáculos desse caminho e a identificar fatores e atores sociais capazes de facilitar ou bloquear essas transformações em direção a um futuro incontestável. Assim, a sociologia argentina construiu, ao longo do tempo, argumentos teóricos sobre a mudança social e o papel da sociedade nacional na história da civilização ocidental.Dessa forma, este artigo reconstrói historicamente essas interpretações sobre progresso, desenvolvimento e modernização em diferentes etapas intelectuais, ao mesmo tempo que percorre o processo de institucionalização da disciplina. Apresentam-se, de maneira sintética e integrada, um conjunto de ideias e interpretações sobre o futuro do país na Geração de 1837, na sociologia do Centenário e na sociologia do período entreguerras. Essa revisão de autores e debates conceituais inclui uma discussão sobre a natureza da mudança, as tensões resultantes, o papel dos grupos sociais na aceleração ou no bloqueio do desenvolvimento e as ferramentas necessárias para superar os obstáculos.A hipótese principal é a existência de uma linha de continuidade entre essas ideias e a teoria da modernização latino-americana da década de 1960. Assim, o projeto de Gino Germani possibilitou a convergência de demandas internacionais para repensar a mudança social na Argentina com uma tradição local de longa duração (em termos culturais, disciplinares e epistemológicos), voltada a refletir sobre essa transição civilizatória, embora com críticas e contestações.
Correlation Cycle Threshold (Ct) values and clinical symptoms of pediatric patients with COVID-19
Authors: Hutabarat Andrew Partogi Hamonangan , Hutabarat Sabar , Aurora Wahyu Inda Dewi
Published: January 2025

Introduction:  The COVID-19 pandemic has affected individuals of all age groups, including children. Understanding the correlation between cycle threshold values and clinical symptoms in pediatric patients with COVID-19 is crucial for accurate diagnosis and management of the disease. This research aims to determine the correlation of Cycle Threshold (CT) Values with Clinical Symptoms Of Pediatric Patients With COVID-19.
Methods: This research uses quantitative design with a cross sectional study approach.  The population in this study was all children diagnosed with COVID-19 at hospitals in Jambi City in 2021. The data for this study were collected by reviewing the medical records of children registered at Jambi City Hospital who were diagnosed with confirmed cases of COVID-19.  Data analysis of this study used univariate and bivariate analysis.
Result: From the characteristics of respondents, it was found that the majority of respondents were aged 11-18 years (58%) and male (58%). From the distribution of clinical symptoms, it was found that some receptors had milder symptoms (48%). The results of this study show that clinical symptoms are significantly associated with low CT values in pediatric patients with COVID-19 (p = 0.000).
Conclusion: CT values show a positive correlation with clinical symptoms in pediatric patients with COVID-19. A rising Ct value might suggest a declining viral load, potentially indicating recovery.
SCIENTIFIC AND THEORETICAL ANALYSIS OF THE MECHANISM FOR ENSURING PUBLIC SAFETY
Authors:   Jamoat xavfsizligi universiteti, Xoʻjamberdiyev Farrux
Published: January 2025

This article analyzes the essence, characteristics, and features of the public safety mechanism, reflecting thoughts and considerations on addressing social issues in society and defining the object and objective aspects of the public safety mechanism in our country. Additionally, the article examines the methodological foundations of public safety, uncovering the general laws of the emergence, development, and stabilization of public safety activities, as well as the scientific system of approaches, principles, and tools. The study explores the concept of public safety, its relationship and connection with the concept of public order, and examines the opinions and views of scholars on this matter. It concludes with the need for a precise definition of the terms "public order" and "public safety" in a single law. Methods such as analysis, synthesis, induction, deduction, and comparative-legal analysis were used in the research. Advanced foreign experience, scientific-theoretical views, and statistical data in practice were studied in the research work, as a result of which proposals and recommendations were developed for the introduction of amendments and additions to the Criminal Code of the Republic of Uzbekistan and other relevant laws and by-laws.
ISSUES OF INTERNATIONAL COOPERATION IN COMBATING DRUG-RELATED CRIMES
Authors:   Toshkent davlat yuridik universiteti, Oʻrazaliyev Murod
Published: January 2025

This article examines the prospects for improving international cooperation in combating drug addiction, the problem of consumption of narcotic drugs and psychotropic substances, and its negative consequences. In particular, international documents aimed at combating drug addiction were analyzed, including the Single Convention on Narcotic Drugs of 1961, the Convention on Psychotropic Substances of 1971, as well as a number of other foreign and domestic legal documents. The global scale of drug use and its negative consequences are highlighted, as well as the importance of international cooperation in addressing such problems as organized crime and corruption. National and international efforts in that regard and the role of international organizations, including the Commonwealth of Independent States (CIS) and the Shanghai Cooperation Organization (SCO), in ensuring their successful implementation are highlighted. The importance of establishing effective international cooperation in combating drug addiction and coordinating the legislative framework of countries in this area was emphasized.
Ernst Bloch ja fasismin luonto
Authors: Louekari Ville
Published: January 2025

Artikkeli käsittelee fasismin kulttuurista sisältöä saksalaisjuutalaisen filosofin Ernst Blochin esseiden pohjalta. Blochin kirjoitukset auttavat ymmärtämään historiallisen fasismin utooppista ideologiaa. Sotienvälisen saksalaisen kriittisen teorian kontekstissa Bloch tarjoaa poikkeavan selityksen fasismin nousulle, korostaen fasismin kulttuurista puolta ja ottaen tosissaan fasistisen utopian viehätyksen. Esitän, että Blochin keskittyminen kulttuurisiin seikkoihin liittyy hänen ajallisuuden filosofiaansa sekä luonnonfilosofiaan. Fasismi sekä omii ajallisesti vanhentuneita käsitteitä, kuten kolmas valtakunta, että rakentaa niiden pohjalta utopiaa, jossa ihmisen ja luonnon suhde on palautettu alkuperäiseen tilaansa.
Esseemuoto ja dialektinen metodi kritiikin välineinä Minima Moraliassa
Authors: Hautamäki Irmeli
Published: January 2025

Minima Moralia koostuu lyhyistä esseistä ja aforismeista, fragmenteista, joiden esitystapa on niin tiivistä, että yhden fragmentin lukemiseen ja sulatteluun voi kulua runsaasti aikaa. Aikana, joka vaatii kaiken tiedon nopeaa ja helppoa kommunikoitavuutta, Adornon tyyli voi ärsyttää. Seuraavassa en puhu Minima Moralian tunnusomaisesta melankoliasta, jonka syitä ei ole vaikea käsittää yleisellä eikä yksityisellä tasolla. Kirja on syntynyt Yhdysvalloissa Kaliforniassa, minne Adorno pakeni toisen maailmansodan aikana kansallissosialistien vainoa. Keskityn sen sijaan Adornon kirjoittamisen tyyliin, esseistiseen ja dialektiseen esitystapaan.
PENGARUH KUALITAS PELAYANAN KESEHATAN TERHADAP MINAT KUNJUNG KEMBALI PASIEN KE RUMAH SAKIT UMUM DAERAH KOTA MATARAM
Authors: ARYANI MENIK , SEPTIKA BAIQ HERDINA , WULANDARI YAYANG ERRY , SUPRATMAN SUPRATMAN
Published: January 2025

In the era of globalization, competition in the field of health services is getting tighter because people are increasingly choosing health service facilities. Patients can ask for all information from various types of hospital services, facilities provided, hospital advantages. Information from various media, both print and electronic, easily. The aim of this research is to determine the influence of the quality of health services on patients' intention to return to the Mataram city regional general hospital, either partially or simultaneously. Quantitative analytical research method with a cross sectional approach with a sample size of 100 people. Data analysis was carried out using SPSS Statistical Program for Social Sciences 2.7. The research results found that partially the quality of health services had a positive and significant effect on intention to return visits. Then, simultaneously, the quality of health services has a positive and significant effect on interest in returning to visit.
ABSTRAKPada era globalisasi, persaingan di bidang pelayanan Kesehatan semakin ketat karena Masyarakat semakin memilih dalam fasilitas layanan kesehatan. Pasien dapat menanyakan semua informasi dari berbagai jenis pelayanan rumah sakit, fasilitas yang diberikan, keunggulan rumah sakit informasi dari berbagai media baik cetak maupun elektronik dengan medah. Tujuan dari penelitian ini untuk mengetahui pengaruh kualitas pelayanan kesehatan terhadap minat kunjung Kembali pasien ke rumah sakit umum daerah kota mataram baik secara parsial maupun simultan. Metode penelitian analitik kuantitatif dengan metode pendekatan cross sectional dengan jumlah sampel 100 orang. Analisis data dilakukan dengan menggunakan SPSS Statistical program for Social Sciences 2.7. Hasil penelitian menemukan bahwa secara pasial kualitas pelayanan kesehatan berpengaruh positif dan signifikan terhadap minat kunjung Kembali. Kemudian secara simultan kualitas pelayanan kesehatan berpengaruh positif dan signifikan terhadap minat kunjung Kembali.
A INTEGRAÇÃO CURRICULAR COMO CAMINHO PARA A EDUCAÇÃO INTEGRAL: PERSPECTIVAS INTERDISCIPLINARES NO ENSINO MÉDIO
Authors: Pedro Vanesa Regina Toigo , Santana Flavio Carreiro de
Published: January 2025

Este artigo tem como objetivo principal investiga como a integração curricular pode favorecer a educação integral no Ensino Médio, com foco na articulação de saberes e a formação integral dos estudantes. A pesquisa baseia-se em uma abordagem teórico-metodológica qualitativa, fundamentada em autores como Delors, Morin, Saviani, Gadotti e Fazenda, que defendem a interdisciplinaridade como prática integrada e transformadora no contexto educacional. A interdisciplinaridade é apresentada como uma ruptura dos paradigmas tradicionais, promovendo uma visão globalizada e articulada do conhecimento, essencial para atender às complexidades da contemporaneidade.Os resultados apontam que a integração curricular, ao articular diferentes áreas do conhecimento, favorece o desenvolvimento de competências cognitivas, socioemocionais e éticas, promovendo a formação integral do sujeito. A interdisciplinaridade emerge como um princípio pedagógico capaz de enfrentar os desafios da complexidade contemporânea, alinhando-se às demandas da Base Nacional Comum Curricular (BNCC), dos Parâmetros Curriculares Nacionais do Ensino Médio (PCNEM) e da Lei de Diretrizes e Bases da Educação Nacional (LDB). Essa abordagem permite aos estudantes relacionar conhecimentos diversos, desenvolver competências essenciais e responder aos desafios do século XXI. No contexto das políticas educacionais atuais, o estudo ressalta a relevância de um currículo que supere a fragmentação disciplinar e valorize a formação integral do sujeito. A Educação Integral, apoiada pela interdisciplinaridade, é apresentada como um instrumento para transformar a escola em um espaço de construção coletiva, capaz de articular saberes científicos e populares e promover o desenvolvimento de cidadãos críticos, éticos e comprometidos com uma sociedade mais justa e inclusiva.
O USO DA TECNOLOGIA PELA POLÍCIA MILITAR DO PARANÁ: INOVAÇÕES E IMPACTOS NA EFICIÊNCIA DO POLICIAMENTO
Authors: Oliveira Cesar Augusto de , Mello Carlos Cesar de
Published: January 2025

A Polícia Militar do Estado do Paraná tem uma função importante na promoção da segurança da população do Estado, a tecnologia como Inteligência Artificial (IA) e Internet das Coisas (IoT) vem contribuindo para esta conjuntura. O objetivo deste artigo foi o de analisar como a tecnologia implantada pela Polícia Militar do Estado do Paraná impacta na eficiência do policiamento. Trata-se de uma revisão descritiva de literatura, por meio de consultas a materiais já publicados e disponibilizados em bases de dados especificas e outras publicações. Consoante se pode verificar das informações mencionadas, foi possível inferir que a integração de tecnologias de IA e IoT, como câmeras de leitura de placa de veículos, sistema DETECTA, Programa Olho Vivo, Câmeras de reconhecimento facial, demonstra que a integração destas tecnologias vem se demonstrando como um marco na otimização das ações da Polícia Militar do Estado do Paraná, bem como de toda a Segurança Pública. Estas tecnologias, ao processar volumes significativos de informações em tempo real, tende a aprimorar a capacidade de avaliação, análise e monitoramento, o que torna possível o reconhecimento de condutas e padrões de situações suspeitas de forma eficaz. Os resultados demonstram benefícios importantes, visto que há uma maior eficiência operacional, potencialização dos recursos, agilidade na prevenção e combate ao crime e otimização do policiamento nas cidades. Assim sendo, é possível mencionar que a tecnologia atualmente presente na Polícia Militar no Estado do Paraná, vem contribuindo de forma relevante no policiamento e combate à criminalidade.
IDENTIFICAÇÃO DE DESAFIOS E OPORTUNIDADES NO DESENVOLVIMENTO DE BARRA DO GARÇAS: UM CAMINHO PARA O FORTALECIMENTO REGIONAL
Authors: Demambro Elizeu
Published: January 2025

Barra do Garças, que se transformou de um centro de garimpo em um polo econômico dinâmico, tem uma base sustentada pela agropecuária, pelo comércio e pelo turismo. O comércio se modernizou e o turismo diversificado atrai visitantes, gerando empregos e aumentando a renda local, consolidando a cidade como um destaque no Vale do Araguaia. O objetivo deste trabalho é analisar o desenvolvimento local do município, identificando seus principais benefícios e desafios, visando propor estratégias para o fortalecimento econômico, social e ambiental da região. A metodologia adotada foi o estudo de caso, utilizando uma abordagem quantitativa para a análise de dados estatísticos e uma abordagem descritiva para a exposição da situação atual da cidade, identificando problemas e propondo soluções. Apesar do crescimento econômico, a infraestrutura e o saneamento básico apresentam desafios que comprometem o desenvolvimento sustentável, como também, problemas de transporte e condições das vias públicas, afetando a mobilidade e a saúde, especialmente nas áreas periféricas.
ATUAÇÃO DA FISIOTERAPIA NA PREVENÇÃO DE DORTS EM TRABALHADORES DA INDÚSTRIA: UMA REVISÃO INTEGRATIVA
Authors: Magalhães Maria Paixão Rodrigues , Braga Filho Francisco Marcelo Alves , Liberato Francisca Rocha Carneiro , Vasconcelos Germana Greicy de , Coutinho Diogenes José Gusmão , Cunha Francisca Maria Aleudinelia Monte
Published: January 2025

Este artigo tem como objetivo analisar a atuação da fisioterapia na prevenção dos Distúrbios Osteomusculares Relacionados ao Trabalho (DORTs) em trabalhadores da indústria, destacando sua importância para a saúde ocupacional, os DORTs são doenças que afetam o sistema musculoesquelético e estão frequentemente associadas a atividades laborais caracterizadas por movimentos repetitivos, posturas inadequadas e sobrecarga física, condições comuns no ambiente industrial. O presente estudo trata-se de uma pesquisa bibliográfica do tipo revisão integrativa da literatura. Foram utilizados os bancos de dado: Biblioteca Virtual em Saúde- BVS, Scientifc Eletronic Librare- Scielo, CAPES e PubMed.  A pesquisa aborda as estratégias utilizadas pelos fisioterapeutas, como a análise ergonômica do ambiente de trabalho, a implementação de programas de ginástica laboral, o acompanhamento contínuo e a educação preventiva dos trabalhadores. Além disso, é discutido o impacto da fisioterapia na redução de lesões, no aumento da produtividade e na melhoria da qualidade de vida dos trabalhadores. Os resultados com base nos sete principais artigos selecionados, apontaram que apesar dos benefícios comprovados, a prática fisioterapêutica enfrenta desafios como a resistência de trabalhadores e empregadores, limitações financeiras e a falta de políticas públicas que incentivem a saúde ocupacional. Conclui-se que a fisioterapia desempenha um papel crucial na prevenção dos DORTs, sendo essencial para a construção de um ambiente de trabalho mais saudável, o que reflete positivamente tanto na saúde dos trabalhadores quanto no desempenho das empresas. A integração da fisioterapia na rotina industrial é um investimento que visa à promoção de saúde e à redução de custos com afastamentos e tratamentos médicos.
GASTROPLASTIA ENDOSCÓPICA NO AUXÍLIO DO EMAGRECIMENTO: REVISÃO DE LITERATURA
Authors: Tuza Fábio Augusto D´'Alegria , Raulino Estelita Ellen Oliveira Souza , Vicini Juliana Rosa , Gomes Tainá Pereira , Barreto Jéssica Tavares , Trindade Nathália Barbosa Araújo , Azevedo Filho Javert do Carmo
Published: January 2025

Introdução: A gastroplastia endoscópica tem emergido como uma alternativa inovadora no tratamento da obesidade, destacando-se por sua abordagem minimamente invasiva em comparação com a cirurgia bariátrica tradicional. Objetivo: analisar, a partir das evidencias da literatura, a eficácia da gastroplastia endoscópica no auxílio ao emagrecimento. Metodologia: Trata-se de uma pesquisa bibliográfica de abordagem qualitativa. Os dados foram coletados em base de dados virtuais. Para tal utilizou-se a BVS, na seguinte base de informação: LILACS; MEDLINE e Google Acadêmico, onde foram selecionados 25 artigos. Resultados: A partir da aplicação da metodologia de análise de conteúdo temática e de uma leitura reflexiva dos dados, emergiram quatro categorias principais, que são apresentadas a seguir: I - Descrição das técnicas e procedimentos na gastroplastia endoscópica; II - Avaliação dos resultados e eficácia na gastroplastia endoscópica; III - Identificação de diagnósticos e condições associadas a gastroplastia endoscópica; IV - Desenvolvimento de recomendações e diretrizes na gastroplastia endoscópica. Conclusão: A gastroplastia endoscópica tem se destacado como uma alternativa promissora no auxílio ao emagrecimento, conforme evidenciado nesta revisão de literatura. Por ser uma técnica minimamente invasiva, apresenta resultados favoráveis em comparação com métodos tradicionais.
A INFLUÊNCIA DE MUTAÇÕES GERMINATIVAS EM GENES BRCA1/BRCA2 NA ESCOLHA DO TRATAMENTO PARA CÂNCER DE MAMA E OVÁRIO
Authors: Gomes Rebecca Nascimento da Silveira , Lopes Juliana de Fatima da Conceição Veríssimo , Martins Leandro Alves , Barbosa Inglid Patrícia , Portela Diego Jales , Lima Kauanny Caroline Ribeiro de , Silveira Júlia Siqueira Fernandes
Published: January 2025

Esse artigo buscou avaliar a influência das mutações germinativas nos genes BRCA1 e BRCA2 na escolha do tratamento para câncer de mama e ovário, considerando os avanços nas terapias direcionadas e estratégias preventivas. A metodologia empregada foi uma revisão sistemática, conduzida de acordo com o protocolo PRISMA, utilizando as bases de dados ScienceDirect e PubMed. Foram analisados 12 estudos, publicados entre 2019 e 2024, que abordam a relação entre mutações BRCA e eficácia terapêutica. Os resultados demonstraram que as mutações em BRCA1/2 estão associadas a uma maior sensibilidade aos inibidores de PARP, que aumentam a sobrevida livre de progressão em pacientes com câncer de mama e ovário. Além disso, estratégias preventivas, como mastectomias e salpingo-ooforectomias profiláticas, emergem como ferramentas eficazes para reduzir o risco de câncer em indivíduos com mutações BRCA, ressaltando-se o impacto da localização das mutações nos resultados clínicos e a relevância da genotipagem para o manejo. Enfatiza-se a importância de pesquisas contínuas para ampliar as indicações terapêuticas e integrar abordagens moleculares, clínicas e preventivas, promovendo uma oncologia verdadeiramente centrada no paciente. A personalização do tratamento, aliada ao aconselhamento genético ético, representam avanços significativos na oncologia, promovendo melhores desfechos clínicos e qualidade de vida para os pacientes.
CAMINHOS PARA A IGUALDADE: JUVENTUDE E DIVERSIDADE NA ESCOLA
Authors: Santos Queila Pereira , Alves Edsangela Gosler Casciano , Coutinho Diógenes José Gusmão
Published: January 2025

A construção de uma escola igualitária exige o acolhimento e a valorização da diversidade em suas múltiplas formas, como a diversidade racial, de gênero, étnica e sexual. Este artigo discute a importância de promover um ambiente educacional inclusivo, onde todas as identidades são respeitadas e reconhecidas, favorecendo a criação de uma convivência mais harmoniosa entre os alunos. Ao explorar práticas pedagógicas voltadas para a inclusão, mostramos como as escolas podem se tornar espaços de igualdade, onde todos os estudantes têm a oportunidade de se desenvolver de maneira plena. A promoção da igualdade na educação vai além do ensino acadêmico, abrangendo a criação de um ambiente seguro, no qual cada aluno se sinta valorizado e parte de uma comunidade. Contudo, esse processo enfrenta desafios significativos, como preconceitos ainda enraizados na sociedade e a falta de preparação dos educadores para lidar com a diversidade. Apesar disso, as oportunidades geradas por práticas inclusivas são imensas, abrangendo o fortalecimento da empatia, da solidariedade e da consciência crítica dos alunos. Este estudo destaca a necessidade de integrar ações pedagógicas que respeitem as diferenças, contribuindo não apenas para o aprendizado acadêmico, mas também para a formação de cidadãos mais conscientes e engajados na construção de uma sociedade mais justa e igualitária.
A CONTRIBUIÇÃO DOS SISTEMAS ERP PARA A ANÁLISE DE NEGÓCIOS: BENEFÍCIOS, DESAFIOS E IMPACTOS NA TOMADA DE DECISÃO
Authors: Souza Ana Paula Marinho de , Braga Gleicy Marques
Published: January 2025

O presente estudo investigou a contribuição dos sistemas ERP para a análise de negócios, com foco nos benefícios, desafios e impactos na tomada de decisão estratégica nas organizações. O problema de pesquisa foi: “De que maneira os sistemas ERP contribuem para a análise de negócios, considerando seus benefícios, desafios e impactos na tomada de decisão?” O objetivo geral foi analisar como os sistemas ERP influenciam a gestão empresarial, especialmente na otimização de processos e na melhoria da tomada de decisão. A metodologia adotada foi a pesquisa bibliográfica, com análise de artigos, livros e outras fontes acadêmicas relevantes. A pesquisa revelou que os sistemas ERP contribuem para a integração de dados e processos empresariais, melhorando a eficiência operacional, a transparência financeira e a colaboração interna. Contudo, os principais desafios enfrentados pelas empresas envolvem a resistência à mudança, os custos elevados de implementação e as dificuldades de integração com sistemas legados. Em relação à tomada de decisão estratégica, os sistemas ERP oferecem dados em tempo real que permitem aos gestores tomar decisões informadas, alinhadas com os objetivos estratégicos. As considerações finais indicaram que, embora os sistemas ERP tragam benefícios substanciais, a implementação bem-sucedida depende da superação dos desafios operacionais e tecnológicos. O estudo também destacou a necessidade de mais pesquisas sobre os impactos a longo prazo desses sistemas em diferentes tipos de organizações.
Wind and Topography Underlie Correlation Between Seasonal Snowpack, Mountain Glaciers, and Late-Summer Streamflow
Authors: Boardman Elijah N. , Fountain Andrew G. , Boardman Joseph W. , Painter Thomas H. , Burgess Evan W. , Wilson Laura , Harpold Adrian A.
Published: January 2025

Abstract. In a warming climate, net mass loss from perennial snow and ice (PSI) contributes a temporary source of unsustainable streamflow. However, the role of topography and wind in mediating the streamflow patterns of deglaciating watersheds is unknown. We conduct lidar surveys of seasonal snow and PSI elevation change for five adjacent watersheds in the Wind River Range, Wyoming (WRR). Between 2019 and 2023, net mass loss from PSI is equivalent to ~10–36 % of August–September streamflow. Across 338 manually classified PSI features >0.01 km2, glaciers contribute 68 % of the total mass loss, perennial snowfields contribute 8 %, rock glaciers contribute 1 %, buried ice contributes 6 %, and the remaining 17 % derives from semi-annual snowfields and small snow patches. Surprisingly, watersheds with more area-normalized seasonal snow produce less late-summer streamflow (r = -0.60), but this correlation is positive (r = 0.88) considering only deep snow storage (SWE >2 m). Most deep snow (87 %) is associated with favorable topography for wind drift formation. Deep seasonal snow limits the mass loss contribution of PSI features in topographic refugia. We show that watersheds with favorable topography exhibit deeper seasonal snow, more abundant PSI features (and hence greater mass loss during deglaciation), and elevated late-summer streamflow. As a result of deep seasonal snow patterns, watersheds with the most abundant PSI would still produce 45–78 % more late-summer streamflow than nearby watersheds in a counterfactual scenario with zero net mass loss. Similar interrelationships may be applicable to mountain environments globally.
Synchronization frequency analysis and stochastic simulation of multi-site flood flows based on the complicated vine copula structure
Authors: Yu Xinting , Xu Yue-Ping , Guo Yuxue , Chen Siwei , Gu Haiting
Published: January 2025

Abstract. Accurately modeling and predicting flood flows across multiple sites within a watershed presents significant challenges due to potential issues of insufficient accuracy and excessive computational demands in existing methodologies. In response to these challenges, this study introduces a novel approach centered around the use of vine copula models, termed RDV-Copula (reduced-dimension vine copula construction approach). The core of this methodology lies in its ability to integrate and extract complex data before constructing the copula function, thus preserving the intricate spatial–temporal connections among multiple sites while substantially reducing the vine copula's complexity. This study performs a synchronization frequency analysis using the devised copula models, offering valuable insights into flood encounter probabilities. Additionally, the innovative approach undergoes validation by comparison with three benchmark models which vary in dimensions and nature of variable interactions. Furthermore, the study conducts stochastic simulations, exploring both unconditional and conditional scenarios across different vine copula models. Applied in the Shifeng Creek watershed, China, the findings reveal that vine copula models are superior in capturing complex variable relationships, demonstrating significant spatial interconnectivity crucial for flood risk prediction in heavy-rainfall events. Interestingly, the study observes that expanding the model's dimensions does not inherently enhance simulation precision. The RDV-Copula method not only captures comprehensive information effectively but also simplifies the vine copula model by reducing its dimensionality and complexity. This study contributes to the field of hydrology by offering a refined method for analyzing and simulating multi-site flood flows.
Effect of intravenous and intraperitoneal lignocaine on post operative pain scores in dogs undergoing ovariohysterectomy
Authors:   Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur- 680651, Stephen Alan V , Ramankutty Soumya , Venugopal Syam K , Varghese Reji , Mathew Manju K , Gleeja V. L.
Published: January 2025

The study was conducted in twelve female dogs of different breeds, randomly divided into two groups of six dogs
each. All dogs underwent a comprehensive pre-anaesthetic evaluation prior to surgery. One hour before the procedure,
the dogs received firocoxib orally. Pre-anaesthetic medication included injections of xylazine and buprenorphine,
followed by induction with ketamine and midazolam. In Group I, lignocaine was administered during induction followed
by a constant rate infusion (CRI), while in Group II, lignocaine was applied directly to the peritoneal cavity and viscera
during surgery. Anaesthesia was maintained with isoflurane in both the groups. The quality of sedation, induction and
recovery from anaesthesia was noted as excellent in both groups. Haematological and serum biochemical parameters
varied within normal acceptable ranges and showed no significant differences between the groups. Electrocardiographic
parameters, blood pressure values and blood gas parameters also remained within normal limits, without significant
differences between the groups. Pain scores were lower in Group II compared to Group I, although the difference was not
statistically significant. Both multimodal anaesthetic protocols proved effective in managing postoperative pain in dogs.
Keywords: Pain, multimodal anaesthesia, multimodal analgesia, OHE, GCMPS
سيميولوجية التواصل عند المرأة في روايات نجيب محفوظ ت (2006م)
Authors: Ahmed Sawsan Hasanen
Published: January 2025

تتعدد وسائلُ التواصلِ والتعبير والإبانة عن مقاصدَ ومكوناتِ النفس، فمنها: التواصل اللفظي، وهو الذي يتم عن طريق استخدام اللغة المنطوقة، والتواصل غير اللفظي ويتم عن طريق وسائلَ كثيرة يمكن تقسيمها إلى قسمين، الأول: أنظمة دلالية عضوية تعتمد على جسم الإنسان، وتتمثل فى: الإشارات، أو الحركات الجسدية، أو الهيئات والأوضاع الجسدية، وغيرها.
القسم الثاني: أنظمة دلالية أدائية تعتمد على أشْيَاءَ خارجَةٍ عن جسم الإنسان، وتتمثل فى الملابس، والحلي، وبعض الأدوات التى تحمل دلالات متباينة فى المجتمعات، مثل: المنديل، والمسبحة، والمروحة، والمظلة، والعصا، وغير
Pengembangan Tes Penguasaan Konsep Two Tier Multiple Choice pada Materi Kalor Menggunakan Model Rasch
Authors: Ananda Putri Novia , Winny Liliawati  , Ridwan Efendi
Published: January 2025

Salah satu tujuan dari pelajaran fisika di tingkat SMA adalah untuk memastikan peserta didik menguasai konsep-konsep yang diajarkan. Untuk itu, diperlukan instrumen tes yang dapat mengukur penguasaan konsep secara tepat. Sehubungan dengan hal ini, guru membutuhkan inovasi dalam bentuk pengembangan instrumen tes two-tier multiple choice. Penelitian ini bertujuan untuk mengevaluasi kelayakan instrumen tes pada materi kalor. Metode yang digunakan dalam penelitian ini adalah research and development (R&D), dengan mengadaptasi langkah-langkah pengembangan instrumen menggunakan model Rasch. Instrumen tes yang dikembangkan terdiri dari 12 butir soal, yang dibagi dalam tiga kategori: 3 soal dengan tingkat kesulitan tinggi, 8 soal dengan tingkat kesulitan sedang, dan 1 soal dengan tingkat kesulitan mudah. Berdasarkan analisis menggunakan software ministep 5.6.4.0, diperoleh hasil bahwa instrumen tes ini valid dan reliabel, dengan nilai Cronbach alpha sebesar 0,71 yang termasuk dalam kategori baik, serta mampu membedakan penguasaan konsep peserta didik berdasarkan tingkat kemampuan tinggi, sedang, dan rendah. Analisis ini menunjukkan bahwa instrumen tes yang dikembangkan dapat digunakan untuk mengukur kemampuan penguasaan konsep peserta didik.
PENGARUH TEKNIK SLOW DEEP BREATHING (SDB) PADA TEKANAN DARAH PADA LANSIA DENGAN HIPERTENSI
Authors: Ardianty Septy , Kasumadewi Monaliza , Sustrisno Sustrisno
Published: January 2025

Latar Belakang: Lansia adalah kondisi seseorang yang telah menua, dimana seiring bertambahnya usia banyak terjadi perubahan pada lansia. Salah satunya adalah perubahan pada sistem kardiovaskular yang ditandai dengan penurunan kerja jantung dalam memompa darah, serta penyempitan pembuluh darah dan menjadi kaku yang dapat mengakibatkan hipertensi. Sehingga perlu ada penanganan khusus untuk mengobati hipertensi pada lansia agar tidak memperburuk situasi. Upaya manajemen keperawatan yang dapat dilakukan dalam pengobatan hipertensi adalah terapi farmakologis yang terdiri dari pemberian obat, dan terapi non-farmakologis seperti teknik Slow Deep Breathing. Melakukan teknik ini secara rutin dapat memberikan efek relaksasi dan dapat menurunkan tekanan darah. Tujuan: Untuk mengetahui pengaruh teknik Slow Deep Breathing terhadap tekanan darah pada lansia dengan hipertensi di wilayah kerja Puskesmas Nagaswidak Palembang tahun 2023. Metode: Penelitian ini merupakan penelitian kuantitatif menggunakan pra-percobaan, dengan satu kelompok pre-test dan post-test design. Teknik pengambilan sampel menggunakan purposive sampling diperoleh oleh 38 responden. Analisis data menggunakan uji-T Paired Sample. Hasil: Nilai tekanan darah rata-rata sebelum intervensi sistolik adalah 165,76 mmHg dan diastolik 89,89 mmHg. Nilai rata-rata tekanan darah setelah intervensi sistolik adalah 159,74 mmHg dan diastolik 85,76 mmHg. Berdasarkan uji statistik, diperoleh nilai p-value=0,001 (p<0,05).Diskusi: Terdapat pengaruh teknik Slow Deep Breathing  pada penurunan tekanan darah pada lansia dengan hipertensi di wilayah kerja Puskesmas Nagaswidak Palembang pada tahun 2023. Dianjurkan untuk penelitian di masa depan untuk menambahkan kelompok kontrol sebagai perbandingan dalam penelitian.
PREPARATION OF l-(+)-CYSTEINE–MODIFIED LOW-GRADE PALYGORSKITE ORE AND ANALYSIS OF ITS REINFORCING PROPERTIES FOR EPDM
Authors: Han Yuanhang , Tang Qingguo , Qiao Yinlong , Wang Fei , Liang Jinsheng
Published: January 2025

The development of palygorskite rubber filler meets the rubber industry’s demand for a low-cost green filler, but the high cost of mineral purification and modifiers limits its industrialization. In an effort to decrease such expenses, this study opted for eco-friendly l-(+)-cysteine as the modifier for organic grafting on the surface of low-grade palygorskite ore. l-(+)-Cysteine–modified low-grade palygorskite rubber reinforcing filler (CYS@PAL) was successfully prepared through ultrafine ball milling and modification. Under the conditions that the modifier dose is 1 wt% and the filling amount of modified powder is 90 phr, the 100 and 300% constant tensile stress, tensile strength, and elongation at break of reinforced EPDM composite reached 4.07 MPa, 7.66 MPa, 24.78 MPa, and 764.70%, respectively. In addition, after thermo-oxidative aging at 70 °C for 48 h, the aging coefficient of the composite rubber reached 0.873. This work provides a low-cost and environmentally friendly method to prepare a high-performance low-grade palygorskite reinforcing filler.
Clinical and Epidemiological Profile of Newborns with Gastroschisis Operated on in a Referral Hospital in Angola
Authors: Lopes Isaura da Conceição Almeida , Simbo Henrique Cotchi , Magalhães Pedro , Belo Silvana , Silva Amílcar
Published: January 2025

Gastroschisis is a congenital malformation characterized by non-closure of the anterior abdominal wall, a paraumbilical defect usually to the right of the umbilical cord with externalization of the intestinal viscera. This study aims to analyze the clinical and epidemiological profiles of gastroschisis cases and examine associations between maternal and neonatal factors in a public referral hospital in Angola. This is an observational, descriptive cross-sectional hospital-based study conducted with the collection of information in 361 newborns medical records with gastroschisis treated at the David Bernardino Pediatric Hospital from January 1st, 2010 to July 15th, 2021. The variables that characterize the clinical, socioeconomic and demographic profile of 361 newborns (NB) with gastroschisis presented the following characteristics: 28% of mothers aged < 20 years; maternal mean age was 22,34+ 4.5 years, the occurrence of death was higher among NB of mothers aged 20 years corresponding to 96.5%,  primiparous 127 (35.2%); without schooling 10 (2.8%), primary education 59 (16.3%), secondary education 43 (11.9%); out-of-hospital births 201  (55.7%); simple gastroschisis 326 (90.3%); primary closure 115 (31.9%); neonatal sepsis 145 (40.2%); mucosal skin pallor 70 (19.4%); gastroschisis-related mortality was 347 (96.1%). The clinical, socioeconomic and demographic profile of mothers and newborns with gastroschisis are widely studied and associated with well-known risk factors, including maternal age under 20 years, out-of-hospital delivery, low level of education, and reduction of the number of prenatal consultations as well as absence of prenatal diagnosis and multiparity.
Garcinia Mangostana Pericarpium Extract: Representation of Vascular Adaptation Based on Circulating Cell Profile
Authors: Nurwidyaningtyas Wiwit , Rizal Ardian , R. Fadlan Mohammad , F. Kemala Yuke , Lara Dewi Sutanti , P. Wardhani Syanindita , Fernando Fernando , Lystia Poetranto Anna , Sargowo Djanggan
Published: January 2025

Long exposure of cardiovascular risk factor were correlated with vascular aging due to interaction of oxidative stress or inflammation exposure leading alteration of vascular adaptation. Garcinia Mangostana Periparpium extract has been reported to display antioxidant effect and immunomodulatory properties. The current research was undertaken to explore the health benefit of Garcinia Mangostana Periparpium extract to vascular adaptation markers of subjects that presence of cardiovascular risk factor. A randomized double-blinded perspective control trial with pre-post design was conducted. The presence of cardiovascular risk factor calculate according Framingham Risk Score (FRS)10 years, each subject were treated with placebo or Garcinia Mangostana for 90 days. Peripheral blood of mononuclear cells (PBMNCs) was obtained from each participant before capsule consumption and one month after the latest capsule consumption. Circulating endothelial cells (CEC) and endothelial progenitor cells (EPCs) level was measured using Flowcytometry assay. The outcomes demonstrate that percentage of the number of CD146/CD45-positive cells/ CEC were significantly lower in treated group compared with the control group, meanwhile percentage of the number of CD133/CD34-positive cells/ EPC was significantly increased in treated group with Garcinia Mangostana Pericarpium. Our finding showed that administration of Garcinia Pericarpium Extract for 90 days could be beneficial for improving varcular adaptation of subject with cardiovascular risk factor based on circulating cell quantification.
Antibacterial and antioxidant activities of Eleutherine americana (Aubl.) Merr. leaves extract growing in different cultivation sites
Authors: Yulia Ningsih Indah , Robbynoor Sulistyono Ilham , Hafizha Zidni , Robiyanto Alwi , Puspitasari Endah , Dianasari Dewi , Amrun Hidayat Mochammad
Published: January 2025

Eleutherine americana (Aubl.) Merr. is used as a traditional remedy in Indonesia. Based on its chemical compounds, the leaves were expected to exhibit antibacterial and antioxidant activities. The aim of the study was to assess the antibacterial capacity, antioxidant capacity, total phenolic content, total flavonoid content, and phytochemical compounds in ethanolic extract of E. americana leaves collected from various cultivation sites, namely West Kotawaringin, Central Kalimantan (EW); Malang, East Java (EM); and Probolinggo, East Java (EP). The antibacterial activity assay was conducted utilizing the diffusion method, whereas the determination of antioxidant capacity was performed utilizing the DPPH method. The total phenolic content and total flavonoid content were determined using UV-Vis spectrophotometry. The phytochemical screening was conducted utilizing a tube test and thin layer chromatography (TLC) method. The growth of E. coli and S. aureus was found to be inhibited by EW, EM, and EP. Furthermore, the antibacterial activity of all samples against S. aureus was higher than that against E. coli. EP had the highest antioxidant activity (IC50 = 32.83±3.51 µg/mL), total phenolic content of 129.40±0.19 mg GAE/g extract, and total flavonoid content of 0.61±0.01 mg QE/g extract. Phytochemical screening revealed that the leaves of E. americana contained alkaloids, terpenoids, flavonoids, polyphenols, and tannins. According to the findings of this study, E. americana leaves could potentially be developed as a new natural antibacterial and antioxidant agent.
Comparative Evaluation of Nebulizer Devices Present in Market and Factors Influencing Nebulizer Performance
Authors: Sambhaji Lalsare Sulabha
Published: January 2025

Pharmaceutical aerosols are frequently used in respiratory drug delivery for the treatment of various pulmonary conditions. A nebulizer device transforms fluid drug into an awfully fine mist that an individual inhalevia mask or mouthpiece. Administering medication in this manner allows it to be directed straight into the lungs and facilitated to the desired site. Traditional pMDIs and DPIs have long been preferred but come with lots of performance issues and patient factors. However, newer nebulization advancementsdeveloped in the last several decades, various nebulizers can now be used for portable use outside of the home, where local medicine administration to the lungs lowers dosage requirements and adverse effects as compared to alternative delivery methods. The primary objective behind the current article is to review the performance of various nebulizers prescribed in the market and their impact on patient safety. The current review deals with the generations of nebulizer devices present in the market along with their significances. The review also covers the mechanism with which these nebulizers operate, and the most important is a difference in the nebulization time of different nebulizers, which directly affects the drug delivery to the site of action.This review covers how important it is to use recommended nebulizers as a difference in nebulization time by using non-recommended nebulizer can lead to hyper or hypo delivery of doses to the site of action, thus leading to resistance and is likely to compromise the safety of patients.