bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPLEMENTATION OF USWAH METHOD AT SMPIT AL MUFID BEKASI
Authors: . Sadan , Mujahidin Endin , Handrianto Budi
Published: September 2023

The implementation of the uswah method at SMPIT Al-Mufid is an analysis of teacher activities to improve their role in education at SMPIT Al-Mufid. The analysis used is direct observation and participation. The subjects analyzed were principals, curriculum waka, student waka, teachers, and learners. Data analysis is carried out by selecting the data obtained and then collected for analysis and conclusions are drawn. The results of the implementation of the uswah method at SMPIT Al-Mufid have been going well, the implementation of teacher uswah in learning such as by preceding greetings in every learning session, being on time in every lesson schedule, greeting students, giving rewards and appreciating students with congratulations and other motivational words for outstanding students. The implementation of teacher uswah in discipline as seen in the application of discipline in school, the implementation of teacher uswah in worship such as with the implementation of prayer in congregation and on time, and the implementation of teacher uswah in cleanliness as seen in terms of throwing garbage in its place and picking up existing garbage and throwing it in its place and dressing neatly and cleanly. The implementation of students' attitudes in their daily lives can be seen in that SMPIT Al-Mufid students are very polite and respectful towards their teachers.
IMPLEMENTATION OF TAHFIZH AND TAFAQQUH FIDDIEN ASSIGNMENTS AT SMPIQU ALBAHJAH AZZAINIYAH BATAM
Authors: Maulana Syafiq , Mujahidin Endin , Handrianto Budi
Published: September 2023

SMPIQU Albahjah Azzainiyah Batam School has one of the leading programs as a local content by implementing the Tahfidz and Tafakkuh Programs Each class must be able to participate in tahfidz and Tafakkuh activities held and assigned by the school. This observation aims to: (1) Know the implementation of tahfizh and Tafakkuh programs and (2) as a step for planning that can be carried out properly to achieve maximum results in the future. Where the development of students in the Albahjah Azzainiyah hut aims to instill the values of piety, independence, discipline, responsibility, simplicity, and skills to realize the vision, mission, goals, and targets of the school. The implementation of the assignment of Tahfidz and Tafaqquh fiddien is an observation of teacher activities to improve their role in education, especially character education at SMPIQU Azzainiyah Batam.  The analysis used is observation and field participation. The subject of this study was a supervisor and teacher at SMPIQU AAlbahjah Azzainiyah Batam. While the object of this study is the Implementation of Tahfidz and Tafakuh Fiddin Assignments at SMPIQU Albahjah Azzainiyah Batam. Data observation is carried out by selecting the data obtained and then collected for analysis and conclusions.  This research uses a qualitative approach, with a case study approach at SMPIQU Azzainiyah Batam. Data was obtained in this study through observation, interviews, and documentation studies. Based on the data obtained, researchers use descriptive analysis, namely by describing or describing what are the findings in the field related to the implementation of the Qur'an tahfidz and tafakkuh programs at SMPIQU Azzainiyah Batam
OPTIMALIZATION OF BREASTFEEDING TECHNIQUES USING “BREAST MODELS”
Authors: Suhaid Dewi Novitasari , Margaretha Manungkalit Eviyani , Kartiko Kusumo Wardani Dyah Woro , Ida Pratiwi Agustina , Leoni Irawan Yetty , Kusmiyanti Margaretha
Published: September 2023

Exclusive breastfeeding is an attempt at enhancing the health and survival of infants during the initial 6 months of life. The World Health Organization (WHO) states that 2 out of 3 infants worldwide do not receive exclusive breastfeeding for the full 6 months. According to UNICEF, it is projected that by 2022, less than half (48%) of infants globally will be exclusively breastfed. The advantages of exclusive breastfeeding for infants encompass the acquisition of antibodies to prevent exposure to diseases, facilitation of brain and physical development, and mitigation of the risk of stunting. The successful practice of exclusive breastfeeding is profoundly affected by both intrinsic and extrinsic factors. Among the intrinsic factors that impact breastfeeding behavior, knowledge stands out. Insufficient or inaccurate information regarding the benefits of breastfeeding, the mechanism of milk production, as well as attachment and breastfeeding positions, are subjects that contribute to challenges in the breastfeeding process. Elevating awareness and comprehension of breast anatomy, milk production mechanisms, and proper attachment during breastfeeding among postpartum mothers will heighten self-efficacy concerning belief in behavioral change. Community service initiatives employ the health education approach utilizing a replica model of breast anatomy. The counseling sessions target parents (both husband and wife) undergoing postnatal health monitoring, and who are recipients of care in the postnatal care unit. The outcomes of this undertaking reveal a noteworthy 35% enhancement in participants' knowledge subsequent to receiving information on breast anatomy, milk production, and proper attachment."
PROCESSING PRODUCTS USING CATFISH AS RAW MATERIAL TO ENHANCE THE VALUE OF CATFISH IN THE SARIWANGI VILLAGE
Authors: Taufik Yusman , Rukmana Jaka , Rahayu Gita , Luwandi Revo , Al-Githrif Muhammad Syamaidzar
Published: September 2023

The activity aims to provide training related to the production of processed food using catfish meat as the main ingredient. Catfish meat has a fine texture and a slightly pale color, allowing it to be categorized as white meat, similar to chicken. Its high protein content and unsaturated fatty acids make catfish meat beneficial for maintaining tissue health, cellular formation, and brain intelligence. Catfish meat is highly recommended for consumption by children in the growth phase, especially toddlers. With its high protein content, low cholesterol level, tender muscle fibers, and more affluent organoleptic properties, catfish meat is preferred by consumers. Efforts to utilize catfish meat have included training on diversifying food products made from catfish meat. Since 2021, the Sariwangi Village Government has collaborated with the Faculty of Engineering at Pasundan University, starting from developing nanobubble technology for catfish farming and focusing more on training for processing products using catfish meat by the year 2023. The intended outcome of this activity is processed food products made from catfish meat that are ready for the market. The products developed are expected to serve as the foundation for a village-owned business unit.
Analysis of Economic Value Added (EVA) and Market Value Added (MVA) in Assessing the Performance of Sharia Financial Institutions (Case Study at PT Bank Sumut Syariah Tbk)
Authors: . Kamilah , Syafina Laylan , Fadhillah Rizka
Published: September 2023

Financial performance is the result or achievement achieved by the company in a certain period which describes the level of the soundness of the company to assist investors or potential investors in making decisions. Assessment of the company's financial performance using the EVA and MVA methods describes the optimal level of return on wealth for the company and investors. The purpose of this research is to measure the financial performance of PT. Bank Sumut Syariah uses the EVA and MVA methods, to determine the amount of economic added value creation and wealth creation that has been generated by the company for creditors and shareholders. This research was conducted at PT. Bank Sumut Syariah for the 2017-2021 period in period studied, Bank Sumut Syariah experienced an increase and decrease in its operational and finances seen from its annual financial reports. Based on the results of the analysis of the value of financial performance using the EVA method, PT. Bank Sumut Syariah has succeeded in creating a positive EVA value for the company every year. Rp. 623,456 (in millions of rupiah) in 2017, Rp. 496,207 (in millions of rupiah) in 2018 experienced a decrease in EVA value from the previous year, Rp. 537,199 (in millions of rupiah) in 2019 the EVA value again increased, in 2020 Bank Sumut Syariah experienced a decrease in the positive EVA value of Rp. 506,628, in 2021 Bank Sumut Syariah has again succeeded in increasing the positive EVA value of IDR 608,185. Management has succeeded in meeting the expectations of both creditors and shareholders.
Household Financial Management In Household Women In Emplasmen Aeknabara Village, Bird Hulu District, Labuhan Batu District
Authors: Indriyani Nova , Prayoga Yudi , Helvi Rambe Bhakti
Published: September 2023

Community Service for Household Financial Management aims to increase knowledge in broadening the understanding of housewives when recording family financial management. A household certainly has the goal of a financially prosperous family, with prosperous finances, of course, the financial management that occurs in the family must have carried out good and efficient financial planning. Financial conditions that are already prosperous must have a savings or investment fund, this is because it will have an impact on the future life of the family. The method used when carrying out this activity is using training and discussion sessions or questions and answers on the elaboration of household financial management. Housewives were trained by giving one problem illustrating a family, of the 15 participants who attended they were very active and responded to the ongoing training activities on the questions they were working on. Participants in the activity, namely housewives as financial managers in a family, must understand the concept of financial planning in the future, to turn a family into a prosperous family.
Application of Range of Motion (ROM) Exercise in the Elderly with Muscle and Joint Weakness
Authors: Susanti Eva , Jawiyah Jawiyah
Published: September 2023

About 10% of the elderly who live at home complain of some limitations in mobility, while the elderly who live in certain institutions are more than 90% dependent on at least one daily activity. The results of research conducted by Anna Hudakova and Anna Hornakova regarding mobility and quality of life in elderly and geriatric patients found that 16% had low mobility, 32% had moderate mobility and 52% had high mobility in geriatric patients with a sample of 321 respondents. The method used is the delivery of material ( counseling) and training by competent resource persons. Through community service activities, efforts are made to improve the degree of public health. Effective ROM (Range Of Motion) counseling and training activities for the elderly can improve the health and independence of the elderly to meet the needs of daily activities in an effort to support government programs namely the Healthy Living Community Movement (GERMAS), especially the elderly community.
Neurodegenerative Diseases and Phytochemicals
Authors: Yıldırım İlknur Gökçe , Doğan Fatma , Şanlıer Nevin
Published: September 2023

Neurodegeneration is defined as the progressive loss of neurons, either structurally or functionally. Alzheimer’s (AD), Multiple Sclerosis (MS), Amyotrophic Lateral Sclerosis (ALS), Huntington’s (HD), and Parkinson’s (PD) are the most important neurodegenerative diseases. Genetic factors, amyloid plaque formation, neurofibrillary tangles, mitochondrial dysfunction, and trauma are all factors involved in the etiopathogenesis of these diseases. Additionally, it has been suggested that neurodegenerative diseases are most likely associated with oxidative stress and neuroinflammation. Various studies have shown that phytochemicals found in fruits, vegetables, nuts, oil seeds, and whole grains have anti-inflammatory, antioxidant, and anti-apoptotic mechanisms of action. Phytochemicals may exert neuroprotective effects through these mechanisms, thus contributing to slowing the progression of diseases. In this review, the effects of phytochemicals with antioxidant and anti-inflammatory effects on neurodegenerative diseases were investigated.
Nutritional Assessment of Kindergartens’ Menus in Terms of Quantity: A Sample of Seven Regions in Türkiye
Authors: Ayhan Büşra , Bilici Saniye
Published: September 2023

Aim: This study was conducted to evaluate the menus of kindergartens in terms of quantity.
Material and Method: A total of 147 autumn menus containing breakfast-lunch or breakfast-lunch-afternoon were evaluated from kindergartens serving in seven geographic regions in Türkiye.
Results: In general, the amount of energy (95.7%), carbohydrate (98.9%) and micronutrients provided by menus was found sufficient, while the amount of calcium was found low (56.6%) and the amount of protein was high (217.4%) than recommendations. It was observed that the sodium (62.0%) and added sugar (8.2%) contents of the menus did not exceed the recommended amounts. In the comparison of the menus between regions, significant differences were observed in some regions in terms of some macro and micronutrients, which could be associated with cultural differences. It was determined that the protein (g) and fat (g) contents of the Mediterranean region menus were lower than the other regions (p<0.008). In the menus of Aegean, Marmara and Black Sea regions, carbohydrate (g) content was found to be higher than other regions (p<0.008). The vitamin C content of the Marmara region’s menus was also higher than the East-Southeast and Central Anatolia regions (p<0.008). The calcium content of the Black Sea region’s menus was higher than the East-Southeast, Central Anatolia, Mediterranean and Marmara regions (p<0.008). It was found that the iron content of the Aegean region’s menus was higher than the East-Southeast, Central Anatolia, Mediterranean and Marmara regions (p<0.008).
Conclusion: Nutrition of children in this period, is effected especially with the effect of kindergartens. For this reason, it is thought that disseminating the National Menu Planning and Implementation Guide for Mass Nutrition Systems (Mass Consumption Places) prepared in accordance with the culture of the society and following the application with such studies will contribute to the solution of a big problem throughout the country.
Türkiye’deki Süt ve Süt ürünlerinin İyot İçeriğinin Belirlenmesi
Authors: Aslan Çin Nazlı Nur , Özfer Özçelik Ayşe
Published: September 2023

Amaç: Türkiye’deki süt ve süt ürünleri iyot miktarlarını belirlemek ve markaya, mevsime, yağ içeriğine ve işlenme özelliğine göre iyot içeriklerini belirlemektir.
Gereç ve Yöntem: Bu çalışmada, tam yağlı, yarım yağlı ve yağsız üretilen toplam altı farklı inek sütü ve 10 farklı süt ürünü örneği çalışmaya dahil edilmiştir. Açık süt örnekleri Türkiye’nin Trabzon ilinde iki farklı üreticiden iki farklı dönemde (Ekim-Kasım ve Nisan-Mayıs) hayvanın beslenmesinde kullanılan yem ile alınmıştır. Aynı sütten yapılan yoğurt, beyaz peynir ve tereyağı da analiz edilmiştir. İyot analizi için endüktif olarak eşleşmiş plazma kütle spektrometresi (ICP-MS) cihazı kullanılmıştır.
Bulgular: Çalışmaya alınan yarım yağlı sütlerin iyot içeriği tam yağlı ve yağsız sütlerden daha yüksek olmakla birlikte, yarım yağlı süt ile yağsız süt arasındaki ortalama iyot içerikleri arasındaki farklar istatistiksel olarak anlamlıdır (p<0.05). Yoğurtta yağ içeriği arttıkça iyot içeriği artmasına rağmen, aradaki fark istatistiksel olarak anlamlı bulunmamıştır (p>0.05). Ultra yüksek ısı yöntemine göre hazırlanan sütlerin ortalama iyot içeriği, pastörizasyon ve kaynatma yöntemine göre istatistiksel olarak anlamlı daha yüksektir (p<0.01). Ekim-Kasım ayında elde edilen sütün iyot içeriği, Nisan-Mayıs ayında üretilen sütün iyot içeriğine göre istatistiksel olarak anlamlı daha yüksek bulunmuştur (p<0.001). Ekim-Kasım dönemindeki sütten elde edilen yoğurt ve beyaz peynir örneklerinin 100 gramındaki iyot miktarı sırasıyla 20.1±7.2 mcg ve 18.7±1.7 mcg iken, Nisan-Mayıs döneminde sırasıyla 11.8±0.3 mcg ve 21.8±0.2 mcg’dir ve aradaki fark istatistiksel olarak anlamlıdır (p<0.05).
Sonuç: Kaynatma ile elde edilen süt ve sütten elde edilen süt ürünlerinin iyot içeriğinin diğer yöntemlere göre daha düşük iyot içerdiği saptanmıştır. Türkiye’de süt ve süt ürünlerinin iyot içeriğinin belirlenmesi için daha fazla örnek sayısının olduğu daha kapsamlı araştırmalara ihtiyaç vardır.
Hazard assessment, complex hygienic standardization of sulfoxaflor in agricultural food raw materials, production and environmental objects; justification of regulations for the safe use of the insecticide based on it
Authors: Kravchuk O.P. , Medvedev V.I. , Zhminko P.G. , Hrynko A.P. , Serhieiev S.G. , Bahatska O.M. , Pavlenko I.P.
Published: September 2023

ABSTRACT. Sulfoxaflor is recommended for use as an insecticide on wheat, barley, rapeseed, sugar beet, apple and cabbage. In the State Enterprise “L.I. Medved’s Research Center for Preventive Toxicology, Food and Chemical Safety, The Ministry of Health of Ukraine” a study was conducted on the toxicological and hygienic assessment of sulfoxaflor and the insecticide Transform, WG based on it; PDD of sulfoxaflor for humans, hygienic standards of the substance and regulations for safe use of the drug are substantiated.

Aim. Toxicological and hygienic assessment of sulfoxaflor and its insecticide, assessment of the risk of exposure to agricultural workers and the population.

Methods. Expert-analytical, toxicological, physico-chemical, hygienic.

Results. According to the parameters of toxicity, sulfoxaflor and the drug Transform, WG belong to pesticides of the 2nd class of danger according to the limiting criterion of harmfulness – the reproductive toxicity of sulfoxaflor. It has a polytropic effect on the body with predominant damage to the liver and reproductive organs. Mutagenic, carcinogenic and teratogenic activity and embryotoxicity of sulfoxaflor are not limiting when assessing its danger.

As a result of field studies, it was established that residual amounts of sulfoxaflor were not detected in the grain of the wheat and barley crops, the seeds of the rape crop and its oil, the roots of the sugar beet crop, the apple crop and their juice, cabbage at the limit level of detection methods.

The degree of possible professional risk of exposure to flupyradifurone in case of entering the body of agricultural workers by inhalation and dermal routes does not exceed the permissible level.

Conclusions. The use of the insecticide Transform, WG based on sulfoxaflor in the agriculture of Ukraine on wheat, barley, rapeseeds, sugar beetroots, apples and cabbage in compliance with hygienic standards and regulations is not dangerous talking about the sulfoxaflor contamination possibility of agricultural crops and environmental objects.

Keywords: insecticide, sulfoxaflor, toxicological properties, hygienic standards and regulations, hazard assessment.
Penerapan Model Budidaya Tanaman Untuk Pencegahan Kerusakan Lahan
Authors: Widowati Widowati , Sa'diyah Ana Arifatus , Darmawan Hariadi , Wilujeng Retno
Published: September 2023

Kabupaten Tuban merupakan salah satu wilayah dengan pertumbuhan industri yang sangat pesat, yang terancam keseimbangan ekologisnya di kawasan hulu yang agraris dan forestris dengan kawasan hilir yang industri. Untuk itu, diperlukan upaya peningkatan pengetahuan dan pemahaman masyarakat serta para pemangku kepentingan tentang percontohan penerapan model budidaya tanaman pencegah kerusakan lahan sebagai peningkatan upaya pencegahan kerusakan lahan. Upaya tersebut dilakukan dengan metode pendekatan kegiatan FGD (Focussed Group Discussion) dalam pelaksanaan kegiatan pengabdian masyarakat, untuk percontohan adalah Desa Jetak, Kecamatan Montong, yang berada di sebelah selatan wilayah Kabupaten Tuban sebagai kawasan hulu. Hasil FGD menjustifikasi keadaan dan status degradasi lahan hutan Bongok di lokasi kegiatan yang terkategori kritis dan perlu dinisiasi dengan Aksi Konservasi dan Restorasi Ekosistem di Hutan Bongok. Aksi ini merupakan penerapan metode vegetatif konservasi dan restorasi lahan, dengan tiga langkah aksi pendampingan, yaitu: penerapan model budidaya tanaman di bawah pohon tegakan, penerapan model pertanian terpadu-tanaman kopi-indigofera-ternak kambing termasuk inisiasi alih teknologi dan inovasi berbasis kopi, serta pengembangan usaha pengolahan produk pertanian-peternakan dan usaha pewarna alami.
Branding Produk Madu Kemlagi Sebagai Potensi Desa Kemlagi, Kabupaten Mojokerto, Jawa Timur
Authors: Aesthetika Nur Maghfirah , Febriana Poppy , Choiriyah Ilmi Usrotin
Published: September 2023

Potensi desa saat ini menjadi salah satu jalan untuk meningkatkan perekonomian masyarakatnya. Penelolaan produk unggulan desa yang baik akan memberikan maanfaat untuk warga desa itu sendiri. Desa Kemlagi Kabupaten Mojokerto memililki produk unggulan madu lokal yang kualitasnya tidak kalah dengan produk madu dipasaran. Untuk meningkatkan produksi dan penjualan madu ini diperlukan strategi branding yang memadai. Oleh karena itu diadakan pelatihan branding produk madu Kemlagi dengan memberikan pengetahuan dan kemampuan branding pada masyarakat Desa Kemlagi sehingga produk ini memiliki identitas yang dapat diterima oleh pasar. Disamping itu, dalam kegiatan ini juga mengenalkan penggunaan media sosial Instagram untuk membantu dalam promosi produk Madu Kemlagi.
Pengelolaan Keuangan Pribadi melalui Permainan Interaktif, Pemaparan Tips Dan Trik, Serta Konsultasi Bagi Komunitas Pemuda GRII Malang
Authors: Prameswari Sielly Budi , Pratita Bernadeta Wahyu Astri
Published: September 2023

Generasi muda adalah harapan dan masa depan bangsa. Permasalahan pada generasi muda memerlukan perhatian serius. Mayoritas generasi muda Indonesia mengalami kecemasan masa depan finansial. Begitu pula halnya dengan generasi muda di kalangan gereja, khususnya GRII Malang. Pengabdi terpanggil untuk melaksanakan pengabdian pada masyarakat yang berjudul “Pengelolaan Keuangan Pribadi melalui Permainan Interaktif, Pemaparan Tips dan Trik, serta Konsultasi bagi Komunitas Pemuda GRII Malang”. Kegiatan abdimas pengelolaan keuangan pribadi ini dilaksanakan pada hari Jumat, 24 Maret 2023. Kegiatan abdimas ini bertempat di Gereja Reformed Injili Indonesia Malang. Sesuai dengan judulnya, Pengelolaan Keuangan Pribadi yang dibawakan pengabdi terdiri dari Permainan Interaktif mengenai pengelolaan keuangan pribadi, pemaparan tips dan trik oleh Pengabdi, serta adanya sesi tanya jawab di bagian akhir. Setelah sesi tanya jawab, diberikan kesempatan bagi para peserta untuk mengisi lembar komitmen pribadi terkait dengan perencanaan dan pengelolaan keuangan pribadi. Hal ini dilakukan agar peserta mengingat akan komitmen pribadi mereka ketika mengelola keuangan pribadi mereka sehari-hari. Mayoritas peserta berpendapat bahwa materi yang dibawakan pengabdi sangat mungkin untuk diterapkan dalam kehidupan sehari-hari. Peserta juga menganggap perlu akan adanya sesi lanjutan terkait beberapa topik sesuai dengan kebutuhan mereka.
The Effect of Different Fertilization Frequency on Some Nutrient Content of Palm Plant Grown in Peat Swamp
Authors: NOVİANA Githa , ARDİANİ Fani , SANTİ Idum Satia , HARTONO Hartono
Published: September 2023

The lack of suitable land (S1) for oil palm plantations is the reason for the current use of marginal land (S3) in oil palm plantations, both for companies and smallholders. Peat swampland has good potential if the care and fertilization of plants is carried out according to the standards according to the conditions of the land. Peat swampland has high acidity, and land conditions are often flooded. Application of fertilizer in a timely manner and the right dose is one of the keys to the success of oil palm plantations. This study aimed to determine the effect of the frequency of fertilizer application on the nutrient content of oil palm leaves. There were three fertilization treatments, namely 1) 0.6 kg/tree was applied once a month, 2) 1.8 kg/tree was applied once per three months, and 3.6 kg/tree was applied once per six months. Data were analyzed using a completely randomized design. The results showed that the frequency of fertilization significantly affected the nutritional content of oil palm leaves. The average nutrient content of fertilization with a frequency of six months has the lowest nutrition compared to other frequencies. The best frequency of fertilization is 0.6 kg/tree, which is applied every month. Fertilization on peatlands that is carried out regularly and in a balanced dose is more important than the application of high doses of fertilizer with a long frequency of fertilization. This is related to palm oil feeding root distribution, which is limited to a swamp depth of 0-60 cm.
On the need to implement a strategic approach in the personnel management of the penal system
Authors: Dolinin Aleksandr
Published: September 2023

The article analyzes strategic approaches to personnel management of modern organizations, the content and results of the implementation of program documents related to the improvement of work with the personnel of the penal enforcement system, and also formulated proposals to improve the personnel strategy of the Federal Penitentiary Service of Russia, contributing to the efficiency of staffing and the activities of personnel services. The topic raised is relevant due to the insufficient elaboration of issues of strategic personnel management of the penal system. In addition, the activities of institutions and bodies of the penal enforcement system in recent years have been carried out in conditions of an acute shortage of personnel, which determines the need to form an effective personnel strategy aimed at high- quality recruitment of staff positions. The analysis of the literature made it possible to identify the main features of strategic personnel management, the objective need to develop personnel strategies. The successful implementation of these areas of the personnel policy of the penal enforcement system will contribute to the improvement of the regulatory and legal support of service.
Assessment of structural shifts in the production sector of the Federal Penitentiary Service of Russia in the Rostov region
Authors: Belova Tat’yana Nikolaevna , Bashkatova Irina
Published: September 2023

The article examines the dynamics and structure of the production of goods and services rendered in the production sector of correctional institutions of the Federal Penitentiary Service of Russia in the Rostov region. It is proposed to choose structural shift coefficients (Ryabtseva, Gateva, Salai) as an assessment tool. This method allows us to evaluate changes in the structure and composition of products in dynamics. Changes in the structure of the production activities of penal institutions are an integral part of the economic strategy and should be aimed at increasing both the economic effect and productivity of convicts. The industrial and economic activity of the GUFSIN of Russia in the Rostov region was chosen as the object of the study. Based on the reporting data for 2014-2021, the coefficients of structural shifts of Ryabtsev, Gatev and Salai were calculated. The analysis showed that the volume of production of goods, works performed and services rendered tended to increase in 2014-2020, but in 2021 a decrease in this indicator was allowed. At the same time, the main branches of production (woodworking, sewing, agriculture, metalworking, food production, etc.) developed differently during the study period, depending on the local factors of production of a particular type of product. The authors come to the conclusion that there is a need for a strategy for the development of industrial and economic activities using convicts' labor.
Provision of food on the basis of long-term supply contracts for public procurement
Authors: Sedyh Vladimir , Rodionov Alexey
Published: September 2023

Ensuring food security is a complex process that requires taking into account a significant number of factors. The article presents the results of a study of the processes of ensuring food security on the basis of long-term contracts for the supply of food for public procurement. It is determined that the public sector of the economy, represented by a significant number of agents, is one of the main players in the food market. It is proved that by now the level of state presence in the sector of agricultural production, its processing and production of food, as well as ready meals has reached minimum values. The article proves the expediency of the transition from the reductive form of contractual relations in public procurement of food to long-term agricultural contracts. Price externalities in the liberalized gas and grain markets are analyzed and promising areas of application of long-term state agricultural contracts in the direction of ensuring national interests and food security of the country are shown.
Social psychology of security: state and prospects
Authors: Sukhov Anatoliy Nikolaevich
Published: September 2023

The article reveals the relevance of the study of the security problem, its socio-psychological essence. At the same time, the difficulties that occur in defining the concept, structure, classification of various types of security are analyzed. The reliability of the national security system is connected with their overcoming. It is no coincidence that the most important task is to create a general theory of security. At the same time socially a psychological approach to understanding various types of security is an integral part of the general theory and practice of its provision. They complement each other. Without this, it is impossible to talk about effective practices for ensuring various types of security.
SPAG17 mediates nuclear translocation of protamines during spermiogenesis
Authors: Agudo-Rios Clara , Rogers Amber , King Isaiah , Bhagat Virali , Nguyen Le My Tu , Córdova-Fletes Carlos , Krapf Diego , Strauss Jerome F. , Arévalo Lena , Merges Gina Esther , Schorle Hubert , Roldan Eduardo R. S. , Teves Maria Eugenia
Published: September 2023

Protamines (PRM1 and PRM2) are small, arginine-rich, nuclear proteins that replace histones in the final stages of spermiogenesis, ensuring chromatin compaction and nuclear remodeling. Defects in protamination lead to increased DNA fragmentation and reduced male fertility. Since efficient sperm production requires the translocation of protamines from the cytoplasm to the nucleus, we investigated whether SPAG17, a protein crucial for intracellular protein trafficking during spermiogenesis, participates in protamine transport. Initially, we assessed the protein-protein interaction between SPAG17 and protamines using proximity ligation assays, revealing a significant interaction originating in the cytoplasm and persisting within the nucleus. Subsequently, immunoprecipitation and mass spectrometry (IP/MS) assays validated this initial observation. Sperm and spermatids from Spag17 knockout mice exhibited abnormal protamination, as revealed by chromomycin A3 staining, suggesting defects in protamine content. However, no differences were observed in the expression of Prm1 and Prm2 mRNA or in protein levels between testes of wild-type and Spag17 knockout mice. Conversely, immunofluorescence studies conducted on isolated mouse spermatids unveiled reduced nuclear/cytoplasm ratios of protamines in Spag17 knockout spermatids compared to wild-type controls, implying transport defects of protamines into the spermatid nucleus. In alignment with these findings, in vitro experiments involving somatic cells, including mouse embryonic fibroblasts, exhibited compromised nuclear translocation of PRM1 and PRM2 in the absence of SPAG17. Collectively, our results present compelling evidence that SPAG17 facilitates the transport of protamines from the cytoplasm to the nucleus.
Pulmonary nocardiosis following COVID-19 in a patient with idiopathic pulmonary fibrosis and lung transplantation: a case report
Authors: Cao Liming , Sun Yilan , Chen Fei
Published: September 2023

Background

Nocardiosis is an opportunistic infection that primarily affects immunocompromised patients. Pulmonary nocardiosis is the most prevalent form, but can also spread to other organs. Potential causes contributing to opportunistic infection may include immunosuppression and disruption of tight junctions, both of which can result from COVID-19.

Case presentation

We reported a case of a 68-year-old male patient who presented with a 10-day history of fever, cough, and productive sputum. Upon physical examination, velcro rales were detected in the right lung, while breath sounds in the left lung were clear. The patient had previously undergone left lung transplantation due to idiopathic pulmonary fibrosis four years ago. He was initially hospitalized and treated for COVID-19 but was readmitted due to worsening symptoms. Subsequently, pulmonary nocardiosis was diagnosed utilizing metagenomic next-generation sequencing of bronchoalveolar lavage fluid. The above-mentioned condition was improved following treatment with cancidas and linezolid. Now, he is under regular follow-up.

Conclusion

This case highlights the complexity of COVID-19 and the occurrence of secondary opportunistic infections, which require further investigation.
Pharmacological rescue of mitochondrial and neuronal defects in SPG7 hereditary spastic paraplegia patient neurons using high throughput assays
Authors: Wali Gautam , Li Yan , Liyanage Erandhi , Kumar Kishore R. , Day Margot L. , Sue Carolyn M.
Published: September 2023

SPG7 is the most common form of autosomal recessive hereditary spastic paraplegia (HSP). There is a lack of HSP-SPG7 human neuronal models to understand the disease mechanism and identify new drug treatments. We generated a human neuronal model of HSP-SPG7 using induced pluripotent stem (iPS) cell technology. We first generated iPS cells from three HSP-SPG7 patients carrying different disease-causing variants and three healthy controls. The iPS cells were differentiated to form neural progenitor cells (NPCs) and then from NPCs to mature cortical neurons. Mitochondrial and neuronal defects were measured using a high throughout imaging and analysis-based assay in live cells. Our results show that compared to control NPCs, patient NPCs had aberrant mitochondrial morphology with increased mitochondrial size and reduced membrane potential. Patient NPCs develop to form mature cortical neurons with amplified mitochondrial morphology and functional defects along with defects in neuron morphology − reduced neurite complexity and length, reduced synaptic gene, protein expression and activity, reduced viability and increased axonal degeneration. Treatment of patient neurons with Bz-423, a mitochondria permeability pore regulator, restored the mitochondrial and neurite morphological defects and mitochondrial membrane potential back to control neuron levels and rescued the low viability and increased degeneration in patient neurons. This study establishes a direct link between mitochondrial and neuronal defects in HSP-SPG7 patient neurons. We present a strategy for testing mitochondrial targeting drugs to rescue neuronal defects in HSP-SPG7 patient neurons.
Integrative evidence construction for resveratrol treatment of nonalcoholic fatty liver disease: preclinical and clinical meta-analyses
Authors: He Xuan , Li Yubing , Deng Xinyu , Xiao Xiaolin , Zeng Jinhao
Published: September 2023

Background: Resveratrol, a polyphenol found in various plants, is known for its diverse bioactivities and has been explored in relation to nonalcoholic fatty liver disease (NAFLD). However, no high-quality evidence exists regarding its efficacy.

Objective: a meta-analysis was conducted to evaluate the potential efficacy of resveratrol in treating nonalcoholic fatty liver disease by analyzing both preclinical studies and clinical trials.

Method: PubMed, Embase and Web of Science were searched for the included literature with the criteria for screening. Quantitative synthesis and meta-analyses were performed by STATA 16.0.

Results: Twenty-seven studies were included, and the results indicated that resveratrol effectively improved liver function, reduced fatty liver indicators, and affected other indices in preclinical studies. The effective dosage ranged from 50 mg/kg-200 mg/kg, administered over a period of 4–8 weeks. While there were inconsistencies between clinical trials and preclinical research, both study types revealed that resveratrol significantly reduced tumor necrosis factor-α levels, further supporting its protective effect against nonalcoholic fatty liver disease. Additionally, resveratrol alleviated nonalcoholic fatty liver disease primarily via AMPK/Sirt1 and anti-inflammatory signaling pathways.

Conclusion: Current meta-analysis could not consistently verify the efficacy of resveratrol in treating nonalcoholic fatty liver disease, but demonstrated the liver-protective effects on nonalcoholic fatty liver disease. The large-sample scale and single region RCTs were further needed to investigate the efficacy.
Positive impact of social relationships fostered by physical and/or cognitive group activity on older people’s quality of life: PRISMA systematic review
Authors: Gonnord Tiphanie , Clarys David , Boucard Geoffroy , Esnard Catherine
Published: September 2023

Introduction

This review identified and examined the research literature on the effect of participating in physical and/or cognitive activities on older people’s quality of life, to establish whether the social relationships fostered by these activities can be a vector of better physical, mental and social quality of life.

Method

A systematic review of the literature was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched four databases (MEDLINE, APA PsycArticles/PsycInfo, PubMed, and Web of Science) for articles published between 1975 and 2022 using search terms related to psychosocial, population, and intervention topics. Studies were eligible if they involved older adults, participation in at least one activity (physical or cognitive), and at least one quality of life related outcome measure.

Results

We selected 20 articles published between 1990 and 2021, the majority concerning studies conducted in English-speaking countries. Ten studies were interventional (introduction of program of activities), and 10 studies were observational (60% quantitative, 40% qualitative). Overall, results revealed a positive impact of the activities on every aspect of quality of life (i.e., cognitive, physical, social, psychological, and quality of life in general).

Conclusion

The present review confirmed the beneficial impact of practicing physical and/or cognitive group activities on older people’s quality of life, but the contribution of social factors and social relationships remains underestimated and not well defined in researches.
Pilot study investigating estrus length and estrus behavior in Norwegian Red cattle on a commercial dairy farm
Authors: Munthe-Kaas Maien , Sveberg Guro , Holmøy Ingrid Hunter , Kommisrud Elisabeth , Haadem Caroline Sorknes , Martin Adam Dunstan
Published: September 2023

Introduction

Norwegian Red has been shown to have high levels of estrus behavior under experimental conditions. However, the estrus behaviors of Norwegian Red cows have not been studied under commercial conditions.

Methods

A herd of 89 Norwegian Red cows housed in free stalls on concrete, slatted floors, were continuously video monitored for 21 days. Ovarian cyclicity was confirmed in a final study sample group (n = 18) using milk progesterone concentrations. All mounting and standing activities were recorded, and the duration of mount estrus, standing estrus and the differences between these; prestand and poststand, were determined. The cycle stages metestrus, diestrus and proestrus were estimated based on the starting time and ending time of mount estrus.

Results

All cows in the final study sample group exhibited the primary estrus sign, ‘standing to be mounted’ during estrus. Two (11%), eleven (61%) and six (33%) cows exhibited the behavior ‘standing to be mounted’ during metestrus, diestrus and proestrus, respectively. The number of mounts initiated by individual cows was higher during mount and stand estrus than during the rest of the estrous cycle. This study reports a median duration of mount estrus and stand estrus of 21.0 h (interquartile range (IQR) 15.0 to 27.3) and 14.3 h (IQR 12.0 to 18.8), respectively. The median counts per hour of all mount behaviors were 8.6 (IQR 5.6 to 11.3), 1.51 (IQR 0.3 to 3.8) and 1.7 (IQR 0.8 to 6.0) for standing estrus, prestand and poststand, respectively.

Discussion

This study shows that under commercial conditions the Norwegian Red cow displays a high level of mount and stand activity associated with estrus.
Development of the standard mouse model for human bacterial vaginosis induced by Gardnerella vaginalis
Authors: Kwak Jinok , Pandey Sriniwas , Cho Jinho , Song Minho , Kim Eun Sol , Doo Hyunok , Keum Gi Beom , Ryu Sumin , Choi Yejin , Kang Juyoun , Kim Sheena , Kim Jeongyun , Kim Hyeun Bum
Published: September 2023

Bacterial vaginosis (BV) is a polymicrobial syndrome characterized by a diminished number of protective bacteria in the vaginal flora. Instead, it is accompanied by a significant increase in facultative and strict anaerobes, including Gardnerella vaginalis (G. vaginalis). BV is one of the most common gynecological problems experienced by reproductive age-women. Because an ideal and standard animal model for human BV induced by G. vaginalis is still underdeveloped, the main objective of this study was to develop a mouse model for human BV induced by G. vaginalis to demonstrate the clinical attributes observed in BV patients. A total of 80 female ICR mice were randomly assigned to 4 groups and intravaginally inoculated with different doses of G. vaginalis: NC (uninfected negative control), PC1 (inoculated with 1 × 105 CFU of G. vaginalis), PC2 (inoculated with 1 × 106 CFU of G. vaginalis) and PC3 (inoculated with 1 × 107 CFU of G. vaginalis). The myeloperoxidase (MPO) activity and serum concentrations of cytokines (IL-1β, IL-10) in mice administered with G. vaginalis were significantly higher than those of the control group. Gross lesion and histopathological analysis of reproductive tract of mice inoculated with G. vaginalis showed inflammation and higher epithelial cell exfoliation compared to the control group. In addition, vaginal swabs from the mice inoculated with G. vaginalis showed the presence of clue cells, which are a characteristic feature of human BV. Altogether, our results suggested that G. vaginalis is sufficient to generate comparable clinical attributes seen in patients with BV.
Time-Tested Strategies in Modern Context: A Bibliometric Study of Chemotherapy’s Continued Importance in Colorectal Cancer Treatment
Authors: Clar-Marmaneu Helena , García-Fernández Alba Estela , García-Fernández Francisco Javier
Published: September 2023

In the landscape of colorectal cancer treatment, classical chemotherapeutic agents such as 5-fluorouracil, capecitabine, irinotecan, oxaliplatin, trifluridine, and tipiracil have historically played a pivotal role. This study presents a comprehensive bibliometric analysis of the top 100 most influential articles focusing on these classic chemotherapy drugs in the management of colorectal cancer. With this, we shed light on their current importance, despite the emergence of new therapeutic targets and treatments in the field of oncology. Systematically evaluating research outputs, this analysis reveals a prevalence of co-authorship among institutions, countries (led by the United States, China, and Europe), and researchers highlighting the global and collaborative nature of efforts in research, utilization, and development of these drugs. Three thematic axes lead the research: pharmacogenetics, the development of new pharmaceutical forms, and the use of adjuvants. This research serves as a foundation for future endeavors, aiding researchers, clinicians, and policymakers in making informed decisions about the direction of research and development in the dynamic field of colorectal cancer therapy.
Occurrence and Diversity of Yeast Associated with Fruits and Leaves of Two Native Plants from Brazilian Neotropical Savanna
Authors: Sperandio Eugenio Miranda , Reis Jefferson Brendon Almeida dos , Coelho Lucas Gabriel Ferreira , Vale Helson Mario Martins do
Published: September 2023

Background: This work studied the occurrence, density, and diversity of yeast species associated with the leaves and fruits of Sabicea brasiliensis and Anacardium humile. Methods: Fragments of leaves and fruits were subjected to maceration and placed under agitation in peptone water. One hundred µL aliquots of each of the decimal dilutions were plated on YM chloramphenicol agar medium. The different morphotypes were identified through sequence analysis of the 26S rDNA. Results: A total of 83 yeast isolates were recovered from the organs sampled, 40 from fruits and 19 from the leaves of S. brasiliensis, while 14 were recovered from fruits and 10 from the leaves of A. humile. The isolates were identified as belonging to two phyla, six classes, eight orders, and eight families. Most isolates, at 71 (84.3%), belong to Ascomycota, with Saccharomycetes dominant in fruits and Dothideomycetes in leaves. The remaining 12 (15.7%) isolates belong to the phylum Basidiomycota. The most frequent genera were Aureobasidium, Candida, Rhodotorula, and Wickerhamiella. The Wickerhamiella isolates made possible the subsequent description of a new species within this genus. Conclusions: Our data reveal the yeast species that inhabit different Cerrado plant organs and indicate that these hosts can be considered an important habitat for yeast diversity, including new and/or previously unreported species in this biome.
Effects of Load Forecast Deviation on the Specification of Energy Storage Systems
Authors: Emde Alexander , Märkle Lisa , Kratzer Benedikt , Schnell Felix , Baur Lukas , Sauer Alexander
Published: September 2023

The liberalization of the German energy market has created opportunities for end-consumers, including industrial companies, to actively participate in the electricity market. By making their energy loads more flexible, consumers can generate additional income and thus save money. Energy storage systems can be utilized to achieve the required flexibility by temporarily storing excess electrical energy in the form of heat, cold, or electricity for later use. This publication focuses on how the dimensionality of energy storage is influenced by load forecasting. The results show that inaccuracies in load forecasting lead to a direct over-dimensioning and thus, a deterioration of the economics of energy storage technologies. Using two scenario cases, it shows on the one hand how important good forecasts are and on the other hand that buffers must be included in the conceptual design in order to be able to compensate for forecast errors.