bluuebunny/crossref_metadata_2025 huggingface dataset:
Hidden gems: a pilot project to solicit and reward patients’ and caregivers’ ideas for research
Authors: Moxham Freya , Cutaran Christine , Sadocha Jakub , Capozza Korey
Published: October 2023

Background

Patients and caregivers investigate a wide range of approaches to address the signs and symptoms of their condition. Such investigation could lead to new treatment insights or avenues for research. However, currently there are few channels through which patients and families can share the results of their personal experiences; they need a platform to share their insights with the research community.

Methodology

Two non-profit organizations, Global Parents for Eczema Research and the International Alliance of Dermatology Patient Organizations, developed a project to pioneer new ways for patients and caregivers to share their personal insights for research and for researchers and treatment developers to learn about those ideas. This project, the “Big Ideas for AD Research”, was a global challenge that awarded prizes and recognition to patients’ and caregivers’ research hypotheses related to atopic dermatitis management, treatment, and prevention.

Results

The Challenge was open for 5 weeks and received 70 submissions from 11 countries. Entries were judged by two separate panels of experts that included both researchers and patients and caregivers. Winners were awarded with a monetary prize, recognized on social media, and connected by Global Parents for Eczema Research staff to an appropriate research group to help further their ideas.

Conclusion

The Big Ideas for Eczema Challenge provided a proof of concept for a novel approach to bridging the gap between patients/caregivers and researchers/clinicians by developing a platform to garner the best ideas from the patient community for research. This model could be further leveraged by other patient groups to help solicit patients’ and caregivers’ ideas for research.
Hepatocyte growth factor pretreatment boosts functional recovery after spinal cord injury through human iPSC-derived neural stem/progenitor cell transplantation
Authors: Suematsu Yu , Nagoshi Narihito , Shinozaki Munehisa , Kase Yoshitaka , Saijo Yusuke , Hashimoto Shogo , Shibata Takahiro , Kajikawa Keita , Kamata Yasuhiro , Ozaki Masahiro , Yasutake Kaori , Shindo Tomoko , Shibata Shinsuke , Matsumoto Morio , Nakamura Masaya , Okano Hideyuki
Published: October 2023

Background

Human induced pluripotent stem cell-derived neural stem/progenitor cell (hiPSC-NS/PC)-based cell transplantation has emerged as a groundbreaking method for replacing damaged neural cells and stimulating functional recovery, but its efficacy is strongly influenced by the state of the injured spinal microenvironment. This study evaluates the impact of a dual therapeutic intervention utilizing hepatocyte growth factor (HGF) and hiPSC-NS/PC transplantation on motor function restoration following spinal cord injury (SCI).

Methods

Severe contusive SCI was induced in immunocompromised rats, followed by continuous administration of recombinant human HGF protein into the subarachnoid space immediately after SCI for two weeks. Acute-phase histological and RNA sequencing analyses were conducted. Nine days after the injury, hiPSC-NS/PCs were transplanted into the lesion epicenter of the injured spinal cord, and the functional and histological outcomes were determined.

Results

The acute-phase HGF-treated group exhibited vascularization, diverse anti-inflammatory effects, and activation of endogenous neural stem cells after SCI, which collectively contributed to tissue preservation. Following cell transplantation into a favorable environment, the transplanted NS/PCs survived well, facilitating remyelination and neuronal regeneration in host tissues. These comprehensive effects led to substantial enhancements in motor function in the dual-therapy group compared to the single-treatment groups.

Conclusions

We demonstrate that the combined therapeutic approach of HGF preconditioning and hiPSC-NS/PC transplantation enhances locomotor functional recovery post-SCI, highlighting a highly promising therapeutic strategy for acute to subacute SCI.
Transarterial interventions in civilian gunshot wound injury: experience from a level-1 trauma center
Authors: Yu Qian , Lionberg Alex , Zane Kylie , Ungchusri Ethan , Du Jonathan , Nijhawan Karan , Clarey Austin , Navuluri Rakesh , Ahmed Osman , Prakash Priya , Leef Jeffrey , Funaki Brian
Published: October 2023

Purpose

To assess the effectiveness of trans-arterial vascular interventions in treatment of civilian gunshot wounds (GSW).

Materials and methods

A retrospective review was performed at a level-1 trauma center to include 46 consecutive adults admitted due to GSW related hemorrhage and treated with endovascular interventions from July 2018 to July 2022. Patient demographics and procedural metrics were retrieved. Primary outcomes of interest include technical success and in-hospital mortality. Factors of mortality were assessed using a logistic regression model.

Results

Twenty-one patients were brought to the endovascular suite directly (endovascular group) from the trauma bay and 25 patients after treatment in the operating room (OR group). The OR group had higher hemodynamic instability (48.0% vs 19.0%, p = 0.040), lower hemoglobin (12.9 vs 10.1, p = 0.001) and platelet counts (235.2 vs 155.1, p = 0.003), and worse Acute Physiology and Chronic Health Evaluation (APACHE) score (4.1 vs 10.2, p < 0.0001) at the time of initial presentation. Technical success was achieved in all 40 cases in which targeted embolization was attempted (100%). Empiric embolization was performed in 6/46 (13.0%) patients based on computed tomographic angiogram (CTA) and operative findings. Stent-grafts were placed in 3 patients for subclavian artery injuries. Availability of pre-intervention CTA was associated with shorter fluoroscopy time (19.8 ± 12.1 vs 30.7 ± 18.6 min, p = 0.030). A total of 41 patients were discharged in stable condition (89.1%). Hollow organ injury was associated with mortality (p = 0.039).

Conclusion

Endovascular embolization and stenting were effective in managing hemorrhage due to GSW in a carefully selected population. Hollow organ injury was a statistically significant predictor of mortality. Pre-intervention CTA enabled targeted, shorter and equally effective procedures.
Effect of different levels of serum progesterone on day of frozen ET on clinical outcome
Authors: Hosseini Sedigheh , Salehpour Saghar , Borujeni Parisa Taherzadeh , Hajizadeh Nazanin
Published: October 2023

Background

Progesterone (P4) plays a critical role in a natural menstrual cycle. It is an essential hormone to have successful embryo implantation into the endometrium.

Objective

In the current study, we compared the clinical outcomes of patients with different levels of P4 on embryo transfer day and aimed to determine the optimum threshold for P4 in the luteal phase.

Material and methods

We performed a prospective cohort study on 100 patients who were referred to the Taleqani Infertility Treatment Institute to undergo frozen embryo transfer (FET). Endometrial preparation was programmed using an estrogen (E2) and progesterone supplement. FET was carried out 3 days after administration of the first dosage of progesterone. We measured serum progesterone levels on embryo transfer day. Clinical pregnancy was the main investigated outcome. We used a parametric receiver operating characteristic curve (ROC) to determine the best-cut points of P4 on embryo transfer day.

Results

Overall, the average endometrial thickness was 7.9 ± 0.2 mm. We observed no association between endometrial thickness and clinical pregnancy (P value = 0.719). The mean number of the transferred embryos in all investigated cycles was 1.5 ± 0.5, and 80.0% of the transferred embryos were high quality (high and medium level). The average progesterone level in cycles with clinical pregnancy was 17.2 ± 3.3 ng/mL. It was only 13.4 ± 9.4 in patients without clinical pregnancy. The observed difference was statistically significant (P value = 0.032). The estimated AUC for the drawn ROC curve was 0.71 indicating a high predictive value.

Conclusion

The current study demonstrated that high and low serum progesterone (P4) levels on embryo transfer day were associated with reduced clinical outcomes following blastocyst transfer during IVF/ICSI. However, more studies with large sizes are required in this regard.
The utility of volumetric MRI in assessment of volume changes in ventral diencephalon in autistic children
Authors: Esmaeel Tamer El Zaeem , Abdelghany Hosny Sayed , Mounir Samir Mohamed , Rasekh Ahmed Ibrahim , Mahmoud Hassan Ali Ahmed , Allam Mohammad Fouad Abdel Baki
Published: October 2023

Background

Autism spectrum disorder (ASD) is a neurobehavioural disorder, characterized by abnormal affiliative and socio-emotional responses which are generally regulated by certain neuropeptides in the hypothalamus (an anatomic component of the ventral diencephalon (VD)). The use of volumetric MRI for studying VD volume change could provide a novel approach for identification of structural brain changes in ASD; this could assist in understanding the pathophysiology of ASD and would reflect on treatment strategies. The aim of the current work was to investigate the role of MRI volumetric analysis of the ventral diencephalon in young children diagnosed with autism spectrum disorder.

Methods

Fifty children diagnosed with ASD underwent volumetric brain analysis, on a fully automated MRI brain volumetry system (volBrain), with voxel-based morphometry of various segmental structures of the brain including the VD, using vol2Brain 1.0 pipeline software analysis suite.

Results

There were 48 out of 50 children who demonstrated abnormal VD volume which was found below the normal limits compared with reference standard normalized volume. All cases were normocephalic demonstrating normal intra-cranial cavity volumes. Forty out of fifty cases showed increased total volume of grey matter, and eighteen out of fifty cases showed increased total volume of white matter. Regarding the amygdala and hippocampus, there were only two cases (4.0%) which showed slightly increased relative volume of the total amygdala, and two other cases (4.0%) demonstrated increased relative volume of the total hippocampus. Comparison between the autistic patients and normal references revealed a significant difference regarding the VD volume and total volume of grey matter, whereas no significant differences were found regarding the white matter amygdala and hippocampus.

Conclusions

Based on the consistent significant volume decrease in the ventral diencephalon in patients with childhood autism, this study concluded that volumetric MRI analysis could be useful for diagnosis of childhood spectrum disorder and could be utilized as a reliable screening method in the clinically vague cases. Further study with a larger sample size including more age groups is recommended for more validation of the results.
Emerging burdens of adolescent psychosocial health problems: a population-based study of 202 040 adolescents from 68 countries
Authors: Rahman Md Ashfikur , Kundu Satyajit , Christopher Enryka , Ahinkorah Bright Opoku , Okyere Joshua , Uddin Riaz , Mahumud Rashidul Alam
Published: October 2023

Background

Psychosocial health problems are major public health burdens for adolescents. Identifying risk factors is essential to containing negative health implications.

Aims

This study aimed to estimate the burden of psychosocial health problems among adolescents, and identify potential risk and protective factors.

Method

We used the Global School-based Student Health Survey data from 68 countries across six World Health Organization regions. We computed the overall, national- and regional-level weighted estimates of the mean number of psychosocial health problems. Adjusted Poisson regression models examined the factors associated with psychosocial health problems.

Results

Our sample totalled 202 040 adolescents aged 11–17 years (mean age 14.6 [s.d. 1.18] years), composed of 95 589 (47.31%) boys and 104 191 (51.57%) girls (2260 (1.12%) missing answers). Samoa had the highest mean number of psychosocial health problems (mean 2.64 [s.d. 1.41]), and Niue had the lowest (mean 0.33 [s.d. 0.72]). In the pooled analysis, the following factors were associated with higher rates of psychosocial health problems in adolescents globally: ≥13 years of age, being female, experiencing food insecurity, experiencing physical violence, having been bullied, engagement in physical altercation, experiencing serious injury, missing school without parental permission, lack of parental support or monitoring, parents who were not understanding of their child's problems and high sedentary behaviour. Being female, food insecurity, bullying, physical attacks or serious injury were all significantly associated with higher rates of psychosocial health problems in each of the six regions separately.

Conclusions

The prevalence of psychosocial health problems is high among adolescents, although there are country-level variations. Health promotion strategies should consider the identified factors to promote adolescents’ health and well-being.
Free Medicine
Authors: Raengo Alessandra
Published: October 2023

Thinking along Ariel Brown's 2021 video history | alchemy | evolution, this introduction approaches “suspension” as a concept, hermeneutic, aesthetic practice, and ethics of intellectual praxis by focusing on the way it dovetails with the radical work the prefix ana- performs in Black studies and the way black aesthetic practices often hinge on anaoriginarity and anachronism as they seek to effect anarchitectural interventions in the languages and institution of artmaking.
Effect of Lifestyle on Reducing Risk Factors for Type 2 Diabetes among Arab Canadian Muslim Women: A Randomized Control Trial
Authors: HUSSIEN SHERIN , MCMANUS RUTH , PRAPAVESSIS HARRY , SOPPER MAGGIE M. , MOTTOLA MICHELLE F.
Published: October 2023

Purpose

This study aimed to investigate whether modifiable risk factors for type 2 diabetes (T2D) can be reduced by an intensive healthy lifestyle intervention designed for Arab Muslim women of Middle Eastern descent (AWMD) who are at high risk for this disease. We hypothesized that among Canadian AWMD, the intervention would (a) reduce the identified health risk factors for T2D (body mass index [BMI], ≥30 kg·m−2; fasting blood glucose [FBG], ≥5.6 mmol·L−1; and waist circumference [WC], ≥80 cm); (b) improve anthropometric measurements; (c) improve lifestyle factors (physical activity level [steps per day] and dietary habits); and (d) improve cardiovascular fitness and reduce blood pressure.

Methods

After informed consent, 60 participants were randomized to either an exercise and nutrition group (ENG; n = 30) or a control group (CON; n = 30). ENG attended a women-only supervised exercise program that presented Arabic music and traditional Lebanese Dabka three times a week in a Mosque gym for 12 wk. A nutritionist was available 1 h·wk−1 for nutrition education. The CON followed their typical day.

Results

ENG and CON had similar increased risk profiles for diabetes at baseline. Large significant pre/posttreatment interaction effects were found for BMI, FBG, and WC with a reduced diabetes risk for ENG compared with CON for BMI (1,58) = 1184.8, P < 0.001), FBG (1,58) = 187.7, P < 0.001), and WC (1,58) = 326.4, P < 0.001). The ENG had significantly more participants reach postintervention target values (BMI: χ
2(1) = 16.48, P = 0.001; FBG: χ
2(1) = 52.26, P < 0.001; WC: χ
2(1) = 4.29, P = 0.038) compared with the CON. Adherence to the program was 100%.

Conclusions

Modifiable risk factors for T2D were reduced by using a culturally sensitive intervention program with high adherence through weight loss, regular exercise, and nutrition education.
Influence of Second-Generation Oral Contraceptives on Muscle Recovery after Repeated Resistance Exercise in Trained Females
Authors: OXFELDT MIKKEL , PEDERSEN ANTON B. , HØRMANN DANIEL , LIND JESPER H. , LARSEN EMIL B. , AAGAARD PER , HANSEN METTE
Published: October 2023

Purpose

Oral contraceptives (OCs) are commonly used by female athletes, but their effects on skeletal muscle are still poorly understood. We investigated if physically trained females using second-generation OCs differed from nonusers of OCs in the recovery of muscle function and muscle damage markers after repeated resistance exercise sessions.

Methods

We recruited 20 trained second-generation OC users and 20 trained nonusers to perform three strenuous resistance exercise sessions. Before, and 3, 24, and 48 h after exercise, blood samples were collected, and participants were evaluated for muscle soreness, maximal isometric and isokinetic muscle strength, vertical jump height, Wingate power performance, leg press strength, and intermittent recovery capacity (yo-yo test). All participants were provided with an energy-macronutrient–balanced diet during the experimental period.

Results

After resistance exercise, maximal isometric and isokinetic muscle strength, rate of force development, vertical jump height, and Wingate peak and average power were reduced, whereas markers of muscle damage were increased in both groups (P < 0.05). OC users experienced a greater reduction in isokinetic strength 3, 24, and 48 h after exercise compared with nonusers of OCs (interaction: P < 0.05). No other interactions were observed.

Conclusions

We demonstrate that measures of muscle strength recovery after three strenuous resistance exercise sessions are comparable between trained females using second-generation OCs and nonusers of OCs. However, group differences were observed for isolated dynamic (isokinetic) muscle strength, suggesting a marginal benefit of not using OCs when accelerated recovery is needed.
Feasibility of Constant Work Rate Testing to Detect Exercise-Induced Laryngeal Obstruction
Authors: THOUGAARD JENS , PEDERSEN LARS , WALSTED EMIL
Published: October 2023

Introduction

Exercise-induced laryngeal obstruction (EILO) is a condition in which laryngeal structures inappropriately obstruct the upper airway during exercise. The standard diagnostic test for EILO is the continuous laryngoscopy during exercise (CLE) test, usually performed with an incremental work rate protocol regardless of the nature of the triggering event. Typically, laryngeal obstruction occurs only briefly at the end of an incremental test, near peak work capacity. We aimed to investigate constant work rate (CWR) protocols for CLE testing to expand diagnostic test modalities and improve the understanding of EILO.

Methods

In this prospective, self-controlled feasibility study, 10 patients with EILO performed both an incremental and a CWR CLE test at 70%, 80%, and 90% of maximal exercise capacity. Laryngoscopic video data were recorded and compared, and we evaluated the ability of CWR to reproduce the symptoms and laryngeal obstruction seen in incremental testing.

Results

In 70%–90% of cases, CWR testing induced at least the same severity of obstruction as incremental testing and CLE scores remained comparable across test modalities. CWR at 70% allowed observation of laryngeal obstruction for a significantly longer duration than in incremental testing (158 s; 95% confidence interval, 25–291 s; P = 0.027). Dyspnea intensity appeared higher during CWR testing compared with incremental testing.

Conclusions

Submaximal CWR CLE testing is feasible and able to induce EILO equivalent to the standard incremental CLE test. This is the first step toward tailored CLE exercise protocols, and further studies are now needed to establish the utility of CWR in clinical and research settings.
Case Report: Incidental discovery of primary peritoneal psammocarcinoma
Authors: Helal Imen , Khanchel Fatma , Jouini Raja , Ben Thayer Maissa , Mbarki Chaouki , Bettaieb Hajer , Rebii Saber , Ben Ismail Imen , Ben Brahim Ehsen , Chedli-Debbiche Aschraf
Published: October 2023

Psammocarcinoma is an uncommon subtype of low-grade serous carcinoma. It is characterized by the presence of extensive psammoma bodies and can have either an ovarian or peritoneal origin. To our knowledge fewer than 30 cases of primary peritoneal psammocarcinoma (PPP) have been reported in the English literature. We report a rare case of  PPP in a 74-year-old female, discovered fortuitously within a laparotomy for gallbladder lithiasis. At laparotomy, multiple nodular implants involving the omentum, the peritoneum and a magma of intestinal loops in the right iliac fossa were noted. A biopsy from nodules was performed. Gross examination showed multiple nodules of different sizes in the fat tissue. Pathologic examination showed massive psammoma bodies representing more than 75% of the tumor. The final diagnosis was psammocarcinoma. Our patient was referred to the gynecologic department for further investigation and to ascertain whether the tumor arose from the ovaries or peritoneum. Hysterectomy, bilateral adnexectomy and omentectomy were performed. Macroscopic examination showed that both ovaries were intact having a normal size. No invasion of ovarian stroma was shown in microscopic examination. The patient died of SARS-CoV-2 (COVID-19) six days after the surgery. PPP is a rare type of  low-grade serous carcinoma. The behavior of this tumor is unclear, and the treatment is not standardized because of its rarity and lack of long-term follow-up. More cases need to be studied for better understanding and improvement of the management protocols.
Observation of SARS-CoV-2 genome characteristics and clinical manifestations within eight family clusters from GH and GK clades in Jakarta, Indonesia
Authors: Ibrahim Fera , Natasha Augustine , Yasmon Andi , Fithriyah Fithriyah , Karuniawati Anis , Rahmawaty Rivia Gina , Saharman Yulia , Sudarmono Pratiwi
Published: October 2023

Background: SARS-CoV-2 rapid mutation generates many concerning new strains. Although lockdown had been applied to contain the disease, the household remains a critical place for its transmission. This study aimed to assess the variation of SARS-CoV-2 strains and their clinical manifestations within family clusters in Jakarta, Indonesia. Method: Naso-oropharyngeal swab specimens from family clusters positive for SARS-CoV-2 were collected for whole-genome sequencing. Their baseline data, symptoms, and source of infection were recorded. The whole-genome data was then analyzed with the bioinformatics program to evaluate the SARS-CoV-2 genome characteristic and submitted to GISAID for strain identification. The phylogenetic tree was built to observe the relationship between virus strain within the family cluster and its clinical manifestation. Result: This study obtained eight family clusters from twenty-two patients. Half of the cluster’s source of infection was a family member who had to work at the office. The infection rate ranged from 37.5% to 100%. The phylogenetic tree showed that the same virus within a cluster could generate various clinical outcomes. Five clusters had one family member with pneumonia, while others had mild to no symptoms. Four breakthrough cases were detected in this study, which were infected by the virus from GH and GK clade. Conclusion: Our study observed the SARS-CoV-2 transmission to the household setting through the workplace, which might become a common pathway if the pandemic status is removed. Although vaccination is expected to reduce the burden of COVID-19, adequate control measures remain essential, given that breakthrough infections are evident.
Case Report: Tuberculosis lymphadenitis with systemic lupus erythematosus in a young woman: a case report
Authors: Arliny Yunita , Yanifitri Dewi Behtri , Utami Wilia Aprilisa , Geraldine Samantha
Published: October 2023

Background: Tuberculosis is a chronic infectious disease and can be categorised into pulmonary TB and extra-pulmonary TB based on its spread. TB lymphadenitis is one of the extra-pulmonary TB diseases. Patients with a weakened immune system in systemic lupus erythematosus (SLE) have an increased incidence of TB. Case: Here we present a case report of a 21-year-old female patient with SLE diagnosed with tuberculous lymphadenitis at dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia. The patient complained of a lump in the right neck 4 months ago with a diameter of 4 cm, accompanied by fever, decreased appetite, and weight loss. Other than that, the patient also experiences joint pain, hair loss and sun sensitivity since 12 months ago. Chest radiography showed no abnormalities, and fine-needle aspiration biopsy results confirmed tuberculous lymphadenitis. Antinuclear antibody test was borderline. The patient had been taking steroids and hydroxychloroquine for the past 10 months. Currently, the patient is taking the advanced phase of antituberculosis drugs FDC. After undergoing the intensive phase of antituberculosis drugs, the submandibular lump got smaller to a diameter of 2 cm. Conclusion: TB lymphadenitis is a rare case but can occur in conditions of decreased immunity like SLE. It involves some of the immune disorders caused by the long-term use of immunosuppressive therapy.
A procedure for estimating fundamental variability
Authors: Uhlig Steffen , Colson Bertrand , Gowik Petra
Published: October 2023

Background: The question whether a given set of test items can be considered “identical” is often addressed in terms of the homogeneity of the test material from which said items were taken. However, for some types of matrices – in particular, for matrices consisting of minute separate particles, only some of which carry the analyte under consideration – even in the case of homogenous test material, an irreducible source of variability between test items may remain: the fundamental variability.

Methods: In this paper, the concept of fundamental variability is explained, and procedures for reducing and characterizing it are described.

Results: The proposed procedure allows both the detection and quantification of the fundamental variability. In addition, it is shown how fundamental variability cannot be identified in homogeneity testing according to Annex B.1.1 in ISO 13528.

Conclusions: The fundamental variability can be brought under control by increasing sample size and by finer grinding of samples. Both of these measures are tantamount to increasing the average number of carrier particles per subsample. The procedure proposed in this paper for characterizing the fundamental variability requires a high number of individual analyses. It therefore makes practical sense to link the proposed procedure with suitable model assumptions in order to then arrive at an estimate of fundamental variability in routine applications with much less effort. The case of heterogenous samples lies beyond the scope of ISO 5725. The question whether irreducible sample heterogeneity should be considered an actual component of an analytical method’s precision has perhaps not yet received sufficient attention. One possible approach would be to distinguish method precision per se (laboratory bias and repeatability precision) from matrix heterogeneity, and to provide information regarding both. Certainly, if the fundamental variability is non-negligible, then it must be accounted for in any evaluation of measurement uncertainty.
Clinical profile of brain abscesses: ten-year retrospective single-center study
Authors: Adhikari Ganesh , Lamichhane Samit , Sapkota Aashish , Shrestha Ajit , Bhatt Nidhi , Raj Bastola Nimish
Published: October 2023

Background: Brain abscess is a rare clinical entity of neurosurgery with poor outcomes. In this study, we aimed to develop clinical profiles of the cases of brain abscesses presented at Chitwan Medical College by reviewing hospital records.  

Methods: The hospital-based retrospective study includes 18 patients presented from April 2013 to April 2023 diagnosed with brain abscess. Data regarding their demographic profile and other factors were collected in well-structured proforma from hospital records, OT records, and ICU records of the neurosurgery department of Chitwan medical college teaching hospital. Data were analysed using SPSS software using frequencies, proportions, and means functions.  

Results: In our study, we reported 18 cases of brain abscess with a mean age of 24.6 years having male to female ratio of 3.5:1. Fever, headache, and focal neurological deficit (classic triad of brain abscess) were present in 16.67 % of the cases. The most common presenting complaint was fever in 61.1 % following headache in 50% of cases. The commonly involved part of the brain was temporal lobe 27.8%. Primary focus of lesion was identifiable in ten cases with CSOM being the most common focus in 44.4% of the case. Consciousness was clear (GCS = 15) in five patients (27.7%), mildly disturbed (GCS = 13 or 14) in 16.7% , moderately disturbed (GCS = 9-12) in 44.5%, and severely disturbed or comatose (GCS = 3-8) in 11.11% of patients. 72.2 % of the cases were managed by craniotomy and evacuation, 11.1% by burr hole and evacuation whereas 16.7% denied any form of treatment.  

Conclusion: The advancement of imaging techniques and the use of IV antibiotics has exponentially improved outcome of the brain abscesses. Furthermore, with CSOM being the most common contagious focus, multidisciplinary management of the cases with brain abscess will benefit the patient.
PERMA well-being and innovative work behaviour : A systematic literature review
Authors: Ibrahim Nor Fauziana , Mohamad Sharif Sabri , Saleh Hasan , Mat Hasan Nor Hasliza , Jayiddin Nur Faezah
Published: October 2023

Background: The purpose of this research is to examine at how the literature measures the relationship between PERMA (positive emotion, engagement, relationships, meaning, and accomplishments) well-being and innovative work behaviour (IWB).

Methods: This systematic literature review examines peer-reviewed English research papers published in 2012 that investigate the relationship between PERMA well-being and IWB. A total of 37 publications were discovered in 32 journals.

Results: A total of 220 articles were initially retrieved from the database. 37 studies out of 220 satisfied the inclusion criteria and were thoroughly examined. Our findings present a comprehensive overview of the types of PERMA well-being related to IWB in different countries and industries. Literature-based research approaches are also discussed. Research methods from the previous literature are also discussed.

Conclusions: This study is one of the first to conduct a systematic literature review (PRISMA) method on the relationship between PERMA well-being and IWB. This review suggests constructive future research directions.
The system of ecological education of preschoolers
Authors: Nikolaeva Svetlana
Published: October 2023

The textbook presents a theoretical (philosophical, natural-scientific and psychological-pedagogical) justification of the methodology of ecological education of preschoolers.
Corresponds to the Federal state educational standard of higher education of the last generation in the field of training "Pedagogical education".
For students and teachers of universities, teachers of colleges of preschool faculties, researchers of preschool pedagogy and environmental education.
Basics of managing the assortment of non-food products
Authors: Moiseenko Nina
Published: October 2023

The textbook details the classification of homogeneous groups of non-food products, their commodity characteristics, properties and assortment indicators. The issues of the state
of the market of groups of goods, conditions and terms of storage of goods are considered. The labeling and packaging of goods are described. Examples of recognizing goods by assortment, identifying the need for goods,
calculating commodity losses and turnover, as well as the profitability of a trading enterprise are given.
The textbook is written in accordance with the requirements of the Federal State Educational Standard of secondary vocational education in the specialty "Commodity science and quality examination of consumer goods" (section "Commodity characteristics of homogeneous groups of non-food products").
Designed for college and technical school students studying under the MDK.01.01 program "Fundamentals of product assortment management", it will also be useful for sales workers.
Bioconversion of secondary raw materials and waste of the agro-industrial complex
Authors: Sidorenko Oleg
Published: October 2023

For the first time, promising biological technologies for processing secondary raw materials and waste from crop production, animal husbandry and the processing industry of the agro-industrial complex (AIC) have been generalized. The main attention is paid to the bioconversion of agricultural raw materials and waste, as well as products of their processing. The technologies in question have an undoubted advantage — they are safe, economical and environmentally friendly. Waste transformation products find practical application in agriculture, industry and medicine. Waste from a dangerous source of pollution turns into valuable goods: organic fertilizers, feed, feed additives, probiotics and combustible materials.
Meets the requirements of the federal state educational standards of secondary vocational education of the latest generation.
It is intended for students of secondary and higher educational agricultural institutions, specialists of the agro-industrial complex, processing technologists of the middle and senior level.
Criminology and crime prevention
Authors: Kuz'mina Natal'ya
Published: October 2023

The textbook presents modern material on all sections of the discipline "Criminology and crime prevention".
The content of the teachings on crime and its causes, the identity of the criminal, the mechanism of committing a specific crime is revealed. The characteristics of the current state of certain types of crime using qualitative and quantitative criminological indicators are given. The problems of carrying out criminological research in the modern period are analyzed using a broad empirical base (including data from criminal law statistics).
The section "Crime prevention System" has a practical orientation, which includes the legal foundations and areas of law enforcement agencies' activities in the implementation of crime prevention and prevention in Russia.
At the end of each chapter of the textbook, a block of control questions and tasks is offered, with the help of which students can test their knowledge and consolidate the studied material.
Meets the requirements of the federal state educational standard of secondary vocational education of the latest generation.
For students of secondary vocational education institutions studying in the specialty 40.02.02 "Law enforcement", as well as teachers.
The history of Russian literature of the late XIX - early XX century. The Silver Age.
Authors: Meskin Vladimir
Published: October 2023

The textbook examines the domestic literature of the Silver Age in the context of Russian and foreign culture. Periodization, content, and poetics of literature are presented here in connection with intra-literary processes and the influence of historical factors. The main part of the book, devoted to poetry, prose, drama, is preceded by a section on the humanitarian consciousness, which occupied, worried, and encouraged a person of the epoch that completed the New Age and began the Modern age, an era that had to begin the modernization of all kinds of art. The introductory section includes an overview of trends in painting, theater, music — in connection with the processes in fine literature. The review paragraphs are supplemented with paragraphs dedicated to the most significant writers.
The textbook meets the requirements of the federal state educational standards of higher education of the latest generation, is intended for undergraduate students of philological faculties, will be useful for undergraduates, graduate students, students of advanced training faculties, teachers of humanities.
Fundamentals of National Accounting (international standard)
Authors: Ivanov Yuriy , Homenko Tat'yana , Tatarinov Andrey , Voskoboynikov Il'ya , Karaseva Larisa , Kazarinova Svetlana , Oztyurk Tat'yana
Published: October 2023

The textbook examines the main provisions of the international standard in the field of national accounting — the System of National Accounts 2008. The fundamental concepts of the system of national accounts are described, such as the concept of economic production and the concept of income, which determine the content of the main indicators of the system, the content of such categories as "economic operation" and "economic asset" is explained. Recent changes are given in the interpretation of a number of important economic transactions, such as spending on research and development, on the acquisition of weapons systems, the issuance of financial intermediation services, the issuance of central bank services. The system of key accounts and its main indicators, such as gross domestic product, gross national income, gross national disposable income, national wealth, as well as methods of their calculation are characterized. The tasks, tests and control questions for all topics are given, as well as a dictionary of the most important terms of the system of national accounts in Russian and English and a list of recommended literature.
The system of national accounts is a special system of ordering data on an innumerable number of economic transactions carried out by a multitude of economic entities. This ordering, based on the most important concepts and definitions of the system of national accounts, allows us to show the relationship between the most significant aspects of the economic process, which is necessary for decision-making by public authorities on the formation of economic policy. The study of the system of national accounts should contribute to the development of economic thinking.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
It is intended primarily for undergraduate and graduate students studying in the field of Economics.
Sociology of well-being
Authors: Kiseleva Lyudmila
Published: October 2023

The monograph develops the theoretical and methodological foundations of the sociology of well-being as an independent branch of sociology designed to investigate how people define and experience well-being. The corresponding terminological apparatus characterizing this direction and applied tools for assessing and measuring the well-being of the Russian population have been developed. Determinants of well-being, factors of well-being, dominants of well-being, domains of well-being are identified as attributes of well-being of individual social groups of Russian society.
A typology of strategic approaches to improving the well-being of the population in Russian regions is presented. A model of the strategic architecture of socially oriented well-being of the population of the region as a special type of well-being, implying the focus of society on future development, has been developed. The practical
value of the research results is associated with the possibility of their use in strategic planning and management of social policy by public authorities at various levels.
For students, postgraduates and teachers of sociological universities and faculties, as well as a wide range of readers interested in welfare issues.
Development of intellectual abilities of older preschool children in various forms of mathematical work
Authors: Stozharova Marina , Sidorova Yuliya , Nurtdinova Leysan , Pazyaeva Yuliya
Published: October 2023

The monograph describes the problem of developing the intellectual abilities of older preschool children in various forms of mathematical work. A detailed experiment with the obtained diagnostic data of children of the experimental study group is described. The system of work with children on the development of their intellectual abilities is presented, the author's program "Young Mathematician" and methodological recommendations for the program of the creative team of kindergarten teachers No. 63 (Ulyanovsk) are proposed. The program was developed under the guidance of Candidate of Pedagogical Sciences, Associate Professor, Professor of the Department of Preschool and Primary General Education of the Ulyanovsk State Pedagogical University named after I.N. Ulyanov M.Yu. Stozharova.
The program is aimed at developing the intellectual abilities of older preschool children.
The program is equipped with diagnostic tools and complete methodological support. The results confirming the effectiveness of the development of intellectual abilities of older preschool children after the work carried out under this program are presented.
It is addressed to teachers, students, postgraduates interested in the problems of modern technological approach in preschool education.
The financial environment of entrepreneurship and entrepreneurial risks
Authors: Kazakova Nataliya
Published: October 2023

The textbook discusses organizational and managerial aspects, institutional factors and the financial environment of entrepreneurial activity. The system of organizational, financial, economic and non-financial indicators, aspects of the development strategy, types of financial, statistical and corporate reporting, as well as business risks and methods of their management are presented.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
It is intended for students enrolled in educational programs in the areas of "Economics" and "Management".
Objects of land legal relations
Authors: Mel'nikov Nikolay
Published: October 2023

The monograph explores the concept and characteristics of objects of land relations, including categories of land, various types of zones, land plots and their parts. The issues of individualization, legal regime and turnover of objects are analyzed, their comparative legal analysis and classification are carried out.
It is intended for researchers in the field of jurisprudence, students of law faculties of universities, lawyers, lawyers, practitioners and other persons interested in land and legal issues.
New trends in digitalization: Russia and the world
Authors: Ponomarenko Elena , Digilina Ol'ga , Shkvarya Lyudmila , Verenikina Anna , Melan'ina Mariya , Nalbandyan Asthik , Oganesyan Ani , Ruzina Elizaveta , Tyrkba Hanifa , Ponomareva Viktoriya
Published: October 2023

The monograph is devoted to digital transformations in Russia and foreign countries. The current problems of the digital economy, digitalization of the branches of government and management, artificial intelligence technology, world experience in the development of "smart" cities, as well as information security and overcoming sanctions restrictions on the development of informatization in the Russian Federation are revealed.
It is intended for students and postgraduates of economic, legal and humanitarian universities and faculties, as well as management specialists, anyone interested in digitalization issues.
Fundamentals of industry strategizing
Authors: Sasaev Nikita
Published: October 2023

The textbook contains theoretical, methodological and methodological foundations of industry strategizing. The main stages of industry strategizing and the procedure for forming the concept of an industry strategy are given. The essence of each of the stages of the survey of the object of industry strategizing is disclosed in detail, namely: strategic diagnostics, strategic analysis of values and interests, trends and development opportunities. The methodology of the primary assessment of the economic efficiency of sectoral strategic priorities and the logical provisions of the formalization and implementation of the sectoral strategy are described.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For Master's degree students studying in the field of Economics, as well as for practitioners in the field of industry strategizing.
Innovation and intellectual property management.
Authors: Gerasimov Kirill , Shihanova Elena , Shkodina Elizaveta
Published: October 2023

The monograph examines the issues of legal regulation of intellectual property in order to specify the specifics of use in various sectors of the economy. The existing tools of intellectual property management are analyzed, the main parameters and attributes of the innovation process are characterized, the main factors influencing the innovative potential of the organization are identified.
It is intended for managers, patent attorneys, specialists in intellectual property management, applicants and consultants in legal and managerial activities, studying under master's and postgraduate programs.
Business Law of the Russian Federation
Authors: Gubin Evgeniy , Lahno Petr , Vaypan Viktor , Shitkina Irina , Haritonova Yuliya , Paraschuk Sergey , Lauts Elizaveta , Kichik Kuz'ma , Afanas'eva Ekaterina , Frolov Igor' , Karelina Svetlana , Molotnikov Aleksandr
Published: October 2023

The textbook was prepared at the Department of Business Law of Lomonosov Moscow State University. Taking into account the interaction of private and public legal means of regulating entrepreneurial activity, volume 1 highlights such important issues as the right to engage in entrepreneurial activity, methods and forms of its implementation, legislation on entrepreneurship, the legal status and responsibility of business entities, including individual entrepreneurs, small and medium-sized enterprises, corporations, legal foundations insolvency (bankruptcy), features of legal regulation in the digital economy, state regulation and control. The material is presented on the basis of the latest legislation with the involvement of judicial practice.
For students, postgraduates and teachers of law schools, as well as for students of economic universities, state and municipal employees, heads of enterprises and organizations, other practitioners, primarily entrepreneurs.
Financial law
Authors: Gracheva Elena , Sokolova El'vira
Published: October 2023

The textbook is written in accordance with the program and thematic plan of studying the course of financial law in educational institutions of secondary vocational education. It was prepared on the basis of the Constitution of the Russian Federation of 1993, the Budget, Tax and Civil Codes, and other regulatory legal acts regulating financial relations in the Russian Federation, taking into account the experience of financial institutions in recent years.
For students in educational institutions of secondary vocational education.
Theoretical and historical legal sciences in the system of modern legal knowledge
Authors: Yaschuk Tat'yana , Birokov Sergey , Evstratov Aleksandr , Ivanov Roman , Kozhevnikov Vladimir , Chechelev Stanislav , Yuricin Aleksandr
Published: October 2023

The monograph provides a systematic view of the theoretical and historical legal sciences. Taken together, they differ from other groups of legal sciences. The peculiarity of each science
included in the studied set is revealed and analyzed. Special attention is paid to the theory of state and law as a fundamental legal science. The development and current state of the history of the state and law of Russia, the history of the state and law of foreign countries, the history of political and legal doctrines are characterized. The group of theoretical and historical sciences includes and examines the philosophy of law and the sociology of law.
For scientists, teachers, postgraduates and students, as well as anyone interested in theoretical and historical-legal problems of legal science.