bluuebunny/crossref_metadata_2025 huggingface dataset:
Bullous scabies.
Authors: Veraldi S , Scarabelli G , Zerboni R , Pelosi A , Gianotti R.
Published: June 2023

No abstract available
Is EMLA effective in Dercum's disease?
Authors: Reggiani M , Errani A , Staffa M , Schianchi S.
Published: June 2023

No abstract available
Extramammary Paget's disease of the axilla with an underlying apocrine carcinoma.
Authors: Morgan JM , Carmichael AJ , Ritchie C.
Published: June 2023

No abstract available
Serum cytokine and anti-Fc gamma R autoantibody measurements in patients with systemic sclerosis.
Authors: Szegedi A , Czirják L , Unkeless JC , Boros P.
Published: June 2023

The serum IL-1 beta, IL-2, IL-4, IL-6, IL-8, TNF-alpha and soluble IL-2 receptor levels were measured, and the presence of anti-Fc gamma receptor (Fc gamma R) antibodies was investigated in the sera of 18 patients with systemic sclerosis (SSc). An increase of TNF-alpha was detected in 8 of the 18 cases. II-1 beta was elevated in all the 18 patients. Both IL-2 and IL-4 were elevated in 7 cases. The IL-6 level was elevated in 17 patients, while IL-8 was increased in all cases. The soluble IL-2 receptor level was elevated in 11 patients. Fc gamma R-specific antibodies were detected in the sera of 6 patients, and there was a significant association between anti-Fc gamma R antibody positivity and IL-4 elevation. The presence of anti-Fc gamma R antibodies may influence several cell functions and may contribute to the remarkable variability of cytokine levels in SSc.
Healing rate of skin ulcers.
Authors: Spencer RP.
Published: June 2023

No abstract available
Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants.
Authors: Darr D , Dunston S , Faust H , Pinnell S.
Published: June 2023

Considerable interest has been recently generated concerning the use of natural compounds, anti-oxidants in particular, in photoprotection. Two of the best known anti-oxidants are vitamins C and E, both of which have been shown to be somewhat effective in different models of photodamage. Very little has been reported, however, on the effectiveness of a combination of the two (known to be biologically the more relevant situation)
Temperature dependency of skin susceptibility to water and detergents.
Authors: Ohlenschlaeger J , Friberg J , Ramsing D , Agner T.
Published: June 2023

Exposure to water and detergents is an important factor for development of irritant contact dermatitis. The aim of the present study was to investigate the effect of temperature on the damaging effects of water and detergents on the skin. Twenty healthy volunteers participated in the study. Ten participants had right and left forearms immersed into a detergent (soap) solution for 2 days twice daily for 10 min. Another 10 participants had both forearms immersed into sterile water. Right and left forearms were randomized to immersion into 20 degrees C and 40 degrees C solutions, respectively. Reactions were evaluated clinically, and by measurement of transepidermal water loss, electrical capacitance and erythema. Immersions into 40 degrees C sodium lauryl sulphate solution caused significantly increased transepidermal water loss as compared to immersion into 20 degrees C sodium lauryl sulphate solution. Electrical capacitance and erythema were not significantly influenced by temperature. Immersion into water caused no significant changes in any observed parameter. Water temperature influences the irritant capacity of a detergent. Change of temperature may be a simple but important means for prevention of irritant contact dermatitis.
Regulation of collagen expression by interleukin-1 beta is dependent on donor age.
Authors: Jarisch A , Krieg T , Hunzelmann N.
Published: June 2023

Cultured skin fibroblasts derived from old (> 60 years) donors differ in various morphological and functional aspects from cells obtained from young (< 20 years) donors. We were interested in whether fibroblasts obtained from old and young donors differ in their cellular response to interleukin-1 beta, a cytokine which has been shown to affect the synthesis of extracellular matrix proteins in human dermal fibroblasts. Therefore the expression of interstitial collagen (type I), minor collagen (type VI) and interstitial collagenase genes was investigated, using fibroblasts derived from either old or young donors. Fibroblasts were incubated in the absence or presence of interleukin-1 beta (5 units/ml, 50 units/ml, 500 units/ml) for 48 h. Total RNA was isolated and mRNA levels were determined by Northern and dot blot analysis. Comparing the synthetic response of fibroblasts obtained from young and old donors, we observed a marked increase of the inhibition of type I and type VI collagen expression and the stimulation of interstitial collagenase in the aged fibroblasts. These results suggest that physiological ageing in human fibroblasts is associated with an altered responsiveness to interleukin-1 beta.
Local expression of migration inhibitory factor and Th1 type cytokine mRNA in sporotrichosis lesions.
Authors: Fujimura T , Asai T , Miyata T , Muguruma K , Masuzawa M , Katsuoka K.
Published: June 2023

No Abstract available
Localised bullous pemphigoid following radiotherapy.
Authors: Cliff S , Harland CC , Fallowfield ME , Mortimer PS.
Published: June 2023

No Abstract available.
Conjugal chondrodermatitis nodularis helicis.
Authors: Camacho F , Ramos ML , Muñoz MA , Moreno JC , Mazuecos J.
Published: June 2023

No Abstract available.
Stage-dependent expression of CD7, CD45RO, CD45RA and CD25 on CD4-positive peripheral blood T-lymphocytes in cutaneous T-cell lymphoma.
Authors: Jakob T , Neuber K , Altenhoff J , Kowalzick L , Ring J.
Published: June 2023

Flow cytometric analysis of T-cell surface markers in peripheral blood has revealed abnormal patterns in patients with cutaneous T-cell lymphomas (CTCL). Here we investigated CD7, CD25, CD45RO and CD45RA expression on CD4+ T-lymphocytes in patients with CTCL stage I/II and III/IV and in patients with severe inflammatory skin diseases (ISD), as well as in healthy controls. Only late stage CTCL (III/IV) showed a lymphocytosis with a distinct surface marker pattern: CD3+, CD4+, CD8-, CD7-, CD45RO+, CD45RA-. Early stage CTCL (I/II) showed normal lymphocyte counts, a normal T-helper cell expression of CD7, CD45RO and CD45RA, and a slightly increased percentage of CD4+ CD25+ lymphocytes, which was also found in ISD. It is concluded that flow cytometric analysis of the above T-cell surface markers may be useful in the diagnosis of patients with late stage CTCL. However it does not allow us to distinguish patients with early stage CTCL from patients with ISD or controls.
Isoprenosine improves symptoms in young females with chronic vulvodynia.
Authors: Sand Petersen C , Weismann K.
Published: June 2023

No abstract available.
Xanthomatous reaction in lupus panniculitis.
Authors: Ishikawa O , Akimoto S , Sato M , Okugi Y , Takeuchi Y , Miyachi Y.
Published: June 2023

No abstract available.
Clinical histochemical and immunohistochemical investigation of the capillary basal membrane in chronic venous insufficiency.
Authors: Peschen M , Zeiske D , Laaff H , Weiss JM , Schöpf E , Vanscheidt W.
Published: June 2023

Present investigations regarding the pathogenesis of chronic venous insufficiency (CVI) are focusing on microvascular changes. The aim of our investigation was to examine the correlation between the thickness of pericapillary type IV collagen depositions, basal membrane alterations and transcutaneous oxygen tension (TcPO2) in CVI-patients. Histochemical and immunohistochemical investigation of the capillary basal membrane was performed on 15 biopsies from normal controls, as well as 30 patients with CVI stage I and III (classification by Widmer & Stähelin). In all subjects TcPO2 was measured just prior to biopsy procedures in exactly the same area where the specimen was subsequently excised. The microscopically measured thickness of the collagen IV layer and the basal membrane was increased significantly in patients with CVI. Specimens from normal controls showed a collagen IV layer thinner than 0.1 micron. Patients with CVI stage III revealed strong collagen IV depositions between 0.2 and 0.3 microns. Comparison between TcPO2 and histological findings in the measured ares showed oxygen pressure varying from 62 mmHg (SEM 4.94 mmHg) in normal controls, down to 13 mmHg (SEM 3.39 mmHg) in patients with thick collagen IV layers. Besides an increased collagen IV layer, microvascular thrombosis and a thickened basal membrane have to be considered for impaired capillary perfusion.
Treatment of chronic idiopathic urticaria with topical steroids. An open trial.
Authors: Ellingsen AR , Thestrup-Pedersen K.
Published: June 2023

Twenty-three patients with chronic idiopathic urticaria and 3 patients with urticaria pigmentosa received a 2-week treatment with daily application of potent topical steroid using plastic occlusion. Seventy per cent of the chronic urticaria patients had a statistically significant, immediate response, which, however, did not last until the final evaluation after 1.5 years. Relapse occurred after on average 3 weeks, but 39% reported less severity. The 3 patients with urticaria pigmentosa remained free from attacks for 6 to 9 months, after which they gradually relapsed. Two women were diagnosed during the follow-up period to have a carcinoma of the breast, and one patient developed systemic lupus erythematosus.
Erythropoietic protoporphyria and terminal hepatic failure.
Authors: Bruch-Gerharz D , Bolsen K , Gerharz CD , Goerz G.
Published: June 2023

We report on a 44-year-old patient with erythropoietic protoporphyria who could effectively control his photosensitivity for 22 years with oral carotinoids. The clinical course of his disorder was complicated by liver involvement, initially expressed as marginally raised serum transaminase levels for several years. Terminal hepatic failure with fatal outcome developed 22 years after manifestation of his liver function abnormalities. Hepatic involvement represents an inconstant and unpredictable feature of erythropoietic protoporphyria, determining the prognosis of an otherwise clinically benign disorder.
Pruritus circumscriptus sine materia: a sequel of postzosteric neuralgia. Evaluation by quantitative psychophysical examination and laser-evoked potentials.
Authors: Darsow U , Lorenz J , Bromm B , Ring J.
Published: June 2023

A case of circumscribed pruritus existing since 1 year on clinically uninvolved skin is reported, in which careful history revealed a 5-year previous episode of herpes zoster in the same dermatome. Impairment of cutaneous sensitivity was evaluated by use of a quantitative psychophysical examination and laser-evoked cortical potentials (LEP).
Lack of sympathetic involvement in dermatitis confined to the median nerve territory. A case report.
Authors: Casale R , Buonocore M , Teofoli P , Matucci-Cerinic M , Elam M.
Published: June 2023

Both decreased and increased sympathetic nerve activity has been suggested as a possible underlying mechanism in inflammatory skin lesions. Modulation of sympathetic function has been proposed in the treatment of dermatitis. This case report describes the investigation strategy and normal findings in a case of dermatitis strictly confined to the median nerve territory, illustrating the need for specific tests of sympathetic function when pharmacological as well as physical sympatho-modulatory therapies are considered.
Recurrent aphthous stomatitis: treatment with pentoxifylline.
Authors: Pizarro A , Herranz P , Navarro A , Casado M.
Published: June 2023

No abstract available.
Pretibial epidermolysis bullosa with vulvar involvement.
Authors: Petersen CS , Brocks K , Weismann K , Kobayasi T , Thomsen HK.
Published: June 2023

No abstract available.
Intralesional bleomycin for the treatment of non-genital warts in HIV-infected patients.
Authors: Shah M , Murphy M , Price JD , Lacey CJ.
Published: June 2023

No abstract available.
Wound healing with a new growth factor formula.
Authors: Veraart JC , Asselman AH , Gronenschild EH , Neumann HA.
Published: June 2023

No abstract available.
Cold urticaria and delayed pressure urticaria in the same patient.
Authors: Valsecchi R , Rozzoni M , Sena P , Pansera B.
Published: June 2023

No abstract available.
Small proline-rich proteins in hair follicles.
Authors: Yoneda K , Imamura S , Kim SY.
Published: June 2023

No Abstract available
Altered distribution of heparan sulfate proteoglycans in psoriasis.
Authors: Seyger MM , Van den Born J , Schalkwijk J , Van de Kerkhof PC , De Jong EM.
Published: June 2023

Heparan sulfate proteoglycans (HSPGs) are components of the basement membrane (BM) of various tissues. They consist of a core protein and negatively charged glycosaminoglycan side chains: the heparan sulfate (HS) moieties. In psoriasis, uninvolved skin of psoriasis patients and in normal skin, the distribution of HSPGs was studied immunohistochemically by means of three different monoclonal antibodies: JM-72, directed against the HSPG-core protein, JM-13 against the sulfated domains of HS and JM-403 against the unmodified/low sulfated parts of HS. In psoriasis JM-13 staining was consistently absent in the tips of the dermal papillae, whereas JM-13 showed a continuous staining in the BM of uninvolved and normal skin. JM-403 staining was present in BM of all specimens. In addition, a honeycomb-like staining was found in epidermis of normal skin and to a lesser extent in uninvolved skin, due to binding with plasma membrane-associated HS. In psoriasis this JM-403 staining of the epidermis was invariably absent. JM-72 showed a continuous staining of BM in all biopsies. In conclusion, normal human skin and involved psoriatic skin show clear differences in expression of HS. These data may provide insight into the role of HSPGs in psoriasis, which remains
Effect of data normalization for age on the correlations between corneometric values and serum molecule levels in plaque-type psoriatic patients.
Authors: Carducci M , Mussi A , Bonifati C , Pietravalle M , Alemanno L , Fazio M , Ameglio F.
Published: June 2023

Corneometry has been considered useful both to evaluate disease severity and to monitor psoriatic patients during treatment. However, a limitation of this technique is that the patient's age influences the corneometric determinations, thus reducing their clinical usefulness. The aim of this study was, therefore, to establish whether age normalization of the corneometric results may provide more reliable data for clinical use. Corneometric levels were determined in 10 plaque-type psoriatic patients, under standard conditions. Eight serum variables, including transforming growth factor-beta 1 and seven soluble membrane molecules, were assayed with commercially available immune-enzyme methods in the same patients, whose age and PASI scores were also recorded. The age normalization procedure improved all the correlation coefficients calculated on the lesional or non-lesional corneometric values versus the PASI scores as well as versus the other serum variables. This approach may render corneometric determinations more useful to evaluate disease status or treatment effect in patient groups with plaque-type psoriasis.
Two hydrocolloid dressings evaluated in experimental full-thickness wounds in the skin.
Authors: Agren MS , Everland H.
Published: June 2023

Hydrocolloid occlusive dressings are beneficial in wound management in many respects, although the adhesive matrix may disintegrate when in contact with wounds. The purpose of this study was to determine: (1) if material from two hydrocolloid dressings-Comfeel and Duoderm-showing differences in adhesive cohesion, can be chemically identified in granulation tissue
Efficacy of pinch grafting in leg ulcers of different aetiologies.
Authors: Ahnlide I , Bjellerup M.
Published: June 2023

The prevalence of leg ulcer disease is high and the health care costs are extensive. Effective therapy is essential to minimise the health care costs and suffering on the part of the patient. If possible, first and foremost, therapy should be aimed at correcting the underlying aetiological defect causing the ulcer. After this has been considered, one of the local therapeutic options is skin grafting using small full thickness skin grafts, i.e. pinch grafting. During the period 1991-1993 altogether 145 therapy-resistant leg ulcers were treated with the pinch graft method at the Department of Dermatology, Malmö University Hospital. The healing rate after 3 months was studied in retrospect. An overall healing rate of 36% was found. The healing rate was dependent on aetiological diagnosis, with a healing rate of 22% in venous and 50% in arterial ulcers. The pinch graft method, which may be used on an out-patient basis offers a simple and relatively effective option in the treatment of leg ulcers. It is recommended as first line skin grafting method. As second line skin grafting method split thickness skin graft, with or without ulcer excision, is recommended.
Patch testing with markers of fragrance contact allergy. Do clinical tests correspond to patients' self-reported problems?
Authors: Johansen JD , Andersen TF , Veien N , Avnstorp C , Andersen KE , Menné T.
Published: June 2023

The aim of the present study was to investigate the relationship between patients' own recognition of skin problems using consumer products and the results of patch testing with markers of fragrance sensitization. Eight hundred and eighty-four consecutive eczema patients, 18-69 years of age, filled in a questionnaire prior to patch testing with the European standard series. The questionnaire contained questions about skin symptoms from the use of scented and unscented products as well as skin reactions from contact with spices, flowers and citrus fruits that could indicate fragrance sensitivity. A highly significant association was found between reporting a history of visible skin symptoms from using scented products and a positive patch test to the fragrance mix, whereas no such relationship could be established to the Peru balsam in univariate or multivariate analysis. Our results suggest that the role of Peru balsam in detecting relevant fragrance contact allergy is limited, while most fragrance mix-positive patients are aware that the use of scented products may cause skin problems.
Increased concentrations of plasma endothelin-1 and fibronectin in psoriasis.
Authors: Yildiz L , Akçay F , Aktas A , Yildiz F , Sahin YN.
Published: June 2023

No abstract available.
Argas reflexus (the pigeon tick)--a household pest.
Authors: Thewes M , Engst R , Hofmann H , Ring J.
Published: June 2023

No abstract available.
Comparison of the analgesic effect of EMLA cream and EMLA patch on normal skin
Authors: Egekvist H , Bjerring P.
Published: June 2023

In the present study the onset, duration and efficacy of the analgesic effect of EMLA patch compared to EMLA cream were investigated on the skin of the forearms of 12 healthy adults. EMLA patch and cream were applied for 30, 60 and 120 min. The pain threshold was determined 5 min after removal of the test substance, using high-energy argon laser stimuli, and thereafter every 30 min for 4 h. After 120 min of application, both EMLA cream and EMLA patch ensured total analgesia. The clinical analgesic efficacy of EMLA patch was found equal to that of EMLA cream.
Transient acantholytic dermatosis (Grover's disease) in a patient with gastric
Authors: De Argila D , Ortiz-Frutos J , Vanaclocha F.
Published: June 2023

No abstract available
Subungual fibro-osseous pseudotumor.
Authors: Moon SE , Park BS , Kim JA , Choe GY.
Published: June 2023

No abstract available
Lymphoedema of the inner thighs in late pregnancy.
Authors: Aronsson A , Roscher I.
Published: June 2023

No abstract available
No evidence for Borrelia burgdorferi infection in lesions of morphea and lichen sclerosus et atrophicus in Spain. A prospective study and literature review.
Authors: Alonso-Llamazares J , Persing DH , Anda P , Gibson LE , Rutledge BJ , Iglesias L.
Published: June 2023

The possible association of Borrelia burgdorferi with morphea and lichen sclerosus et atrophicus has been the focus of research and discussion in dermatology during the last 10 years. To investigate the etiopathogenic role of B. burgdorferi in morphea and lichen sclerosus et atrophicus lesions in Spain, we studied 14 cases: 8 patients with lichen sclerosus et atrophicus and 6 with morphea. For the whole group, a prospective study was performed, including serologic studies by indirect immunofluorescence, histologic evaluation of skin biopsy specimens, culture studies, and polymerase chain reaction with different primers sensitive for detecting virtually all B. burgdorferi strains tested to date. Although one patient with morphea had positive serologic findings at low titer, we were not able to culture or detect borrelial DNA in any of the specimens. These findings do not confirm an association between B. burgdorferi and morphea and lichen sclerosus et atrophicus.
Markers in cutaneous lupus erythematosus indicating systemic involvement. A multicenter study on 296 patients.
Authors: Tebbe B , Mansmann U , Wollina U , Auer-Grumbach P , Licht-Mbalyohere A , Arensmeier M , Orfanos CE.
Published: June 2023

Lupus erythematosus (LE) is an autoimmune disorder, involving the skin and/or other internal organs. As cutaneous variants, chronic discoid LE (CDLE) and subacute cutaneous LE (SCLE) usually have a better prognosis, however, involvement of internal organs with transition into systemic disease may occur. The aim of this study was to assess the significance of some clinical and laboratory criteria that could serve as markers for early recognition of systemic involvement in cutaneous LE. Three hundred and seventy-nine patients with LE, seen in five cooperating Departments of Dermatology during the years 1989-1994, were documented by electronic data processing according to a common protocol. Two hundred and forty-five of these patients had cutaneous LE (CDLE or SCLE), and 51 had systemic LE (SLE) and were included in this study. Forty-nine patients with either CDLE/SCLE or SLE were not evaluated because of incomplete documentation
Effect of ebastine on mosquito bites.
Authors: Reunala T , Brummer-Korvenkontio H , Petman L , Palosuo T , Sarna S.
Published: June 2023

Mosquito bites usually cause wealing and delayed bite papules. Cetirizine decreases wealing, bite papules and pruritus but the effect of other antihistamines on mosquito bites is unknown. We studied the effect of ebastine in 30 mosquito bite-sensitive adult subjects. Ebastine 10 mg or 20 mg and placebo were given for 4 days in a cross-over fashion. Aedes aegypti bites were given on forearms. The size of the bite lesions and pruritus (visual analogue score) were measured at 15 min, 2, 6, and 24 h after the bites. Twenty-five subjects were evaluable in the study. At 15 min ebastine decreased significantly the size of the bite lesion (p = 0.0017) and pruritus (p
Immunohistochemical detection of cathepsins in Merkel cell carcinomas.
Authors: Thewes M , Engst R , Ring J.
Published: June 2023

No abstract available
Comparison of immune reactivity profiles against various environmental allergens between adult patients with atopic dermatitis and patients with allergic respiratory diseases.
Authors: Matsumura N , Aiba S , Tanaka M , Aoyama H , Tabata N , Tamura G , Tagami H.
Published: June 2023

To clarify the pathomechanisms underlying the involvement of different organs by atopic dermatitis (AD) and allergic respiratory disease (ARD), we compared the immune reactivities to various environmental allergens between 46 adult patients who suffered only from AD but were without any history of ARD and 41 patients who had only ARD, using a RAST FEIA (radioallergosorbent test/fluoroenzyme immunoassay) and a scarification patch test. We also studied 42 healthy adult subjects in a similar fashion. Total serum IgE antibody levels were found to be far higher in the AD group than in the ARD and healthy control group, and RAST revealed that the AD group was sensitized to far larger numbers of allergens such as food mix, cereal mix, fungus mix and Candida albicans than were the other groups. The ARD group displayed a high incidence in RAST, comparable to that of the AD group, only against Japanese cedar and grass pollen mix antigen. However, the most remarkable difference in the immune reactivity profiles was that the AD group showed a uniquely higher RAST score and a lower incidence of positive patch test reactions to C. albicans antigen than did the ARD group. The reactivities in the ARD group to C. albicans antigen did not differ from those in the control group. Our present data suggest that a more pronounced shift from Th1 to Th2 cells, reactive against various allergens, takes place in AD patients.
Isotretinoin, tetracycline and circulating hormones in acne.
Authors: Palatsi R , Ruokonen A , Oikarinen A.
Published: June 2023

Isotretinoin, used to treat severe acne, has been shown to induce hormonal changes, especially to reduce 5 alpha-reductase in the production of the tissue-derived dihydrotestosterone (DHT) metabolite 3 alpha-Adiol G. However, the effects of isotretinoin on other pituitary, adrenal or gonadal hormones have not been thoroughly elucidated. In the present study, isotretinoin administered at a dose of 0.5 mg/kg/day for 4 weeks caused no marked changes in the serum levels of pituitary, adrenal or gonadal hormones or 3 alpha-Adiol G in patients with severe papulopustulotic acne (n = 19). After 12 weeks of therapy, there was a decrease in the levels of the precursor androgens androstenedione, testosterone and 3 alpha-Adiol G in 6/9 patients. Acne improved after 4.5 months in all but 2 male patients, who had very low serum hormone binding globulins (SHBG) and a high free androgen index (FAI). Isotretinoin did not affect the elevated LH/FSH ratio in a patient with the polycystic ovarian syndrome (PCOS)
Oral psoriasis: report on a case without epidermal involvement.
Authors: Rozell B , Grevér AC , Marcusson JA.
Published: June 2023

No Abstract available
Cancer induction by immunosuppression in psoriasis after heavy PUVA treatment.
Authors: Molin L , Larkö O.
Published: June 2023

No Abstract available
Normal serum adenosine deaminase activity in mycosis fungoides.
Authors: Yalçin B , Sahin S , Ciliv G.
Published: June 2023

No Abstract available
An uncommon case of the acute disseminated haemorrhagic bullous type of dermatitis ulcerosa.
Authors: Weisshaar E , Sabel R , Gollnick H.
Published: June 2023

No Abstract available
Inducible nitric oxide synthase demonstrated in allergic and irritant contact dermatitis.
Authors: Ormerod AD , Dwyer CM , Reid A , Copeland P , Thompson WD.
Published: June 2023

Eight allergic patch test reactions, eight irritant skin reactions induced by 3% sodium lauryl sulphate and six normal controls were biopsied. Biopsies were immunohistochemically stained with a mouse monoclonal antibody to inducible nitric oxide synthase (iNOS), and staining was quantified by computerised image analysis. Human chondrocytes induced to express iNOS were used as a positive control. A significant increase in iNOS was found in both irritant and allergic contact dermatitis. There were no differences in the distribution of expression of iNOS. The antibody used was confirmed by Western blotting not to cross-react with the endothelial isoform of nitric oxide synthase (NOS) but did cross-react with a 150 kDa protein, which may be neuronal NOS or an isoform of neuronal NOS.
Epidermal sheet grafts for repigmentation of vitiligo and piebaldism, with a review of surgical techniques.
Authors: Olsson MJ , Juhlin L.
Published: June 2023

Thin epidermal sheets, obtained by a high-speed air-driven dermatome, were used to repigment white areas in 19 patients with vitiligo and one boy with piebaldism. In the depigmented skin to be treated the epidermis was removed by a
Widespread cutaneous cryptococcosis occurring in an immunocompromised patient treated with high doses of fluconazole for oro-pharyngeal candidosis.
Authors: Alessandrini F , Allegrini F , Baldari U , Cancellieri C.
Published: June 2023

No Abstract available
Koebner phenomenon in classic Kaposi's sarcoma.
Authors: Potouridou I , Katsambas A , Pantazi V , Armenaka M , Vareltzidis A , Stratigos J.
Published: June 2023

No Abstract available
Erythema multiforme major in a female with acute systemic meningococcal disease.
Authors: Kristensen JH , Hagelskjaer LH , Prag J.
Published: June 2023

No Abstract available
Zosteriform lichen planus without evidence of herpes simplex virus or varicella-zoster virus by polymerase chain reaction. Report of two cases.
Authors: Lutz ME , Perniciaro C , Lim KK.
Published: June 2023

No Abstract available
CO2 laser treatment causes local tattoo allergic reaction to become generalized.
Authors: Zemtsov A , Wilson L.
Published: June 2023

No Abstract available
Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto's disease) with cutaneous involvement.
Authors: Rosina P , D'Onghia FS , Barba A , Colombari R , Chieregato C.
Published: June 2023

No Abstract available
Erythema annulare centrifugum and intestinal Candida albicans infection--coincidence or connection?
Authors: Schmid MH , Wollenberg A , Sander CA , Bieber T.
Published: June 2023

No Abstract available
Is there any Relationship between Body Weight and Urine Ketones?
Authors: HS Hussain
Published: June 2023

The objective of this study was to correlate normal body weight with urine ketones. When there is insufficient level of glucose in our body, body use fats as an alternate source of energy. The substance produced is known as ketones, this will be shown in our blood and urine. If the patients are diabetics, then urine contain ketones means we are not producing insulin. There is another condition in which we are not diabetics but can develop ketones. Life of a patient or an individual is highly affected by its weight. Cardiac vascular diseases are all due to the overweight than to normal. Pulmonary disorders are also the results of overweight. People were asked to collect their urine in a container and then we imposed the dipstick method and analyzed the results for the ketones in the urine and noted the readings of the people. A questionnaire was prepared and asked the people about weight and ketones presence in their urine. All the experiments were conducted when the persons were at normal conditions. None of them is using any medicines or certain kind of drugs. The data described us that there was not a scientific relationship between the human body weight and urine ketones. It was inferred that there was no relationship between the body weight and normal ketones in urine.
Perception of Pandemic in Italy at Early 2022: An Analysis using Traditional and Social Media
Authors: Sia Paolo Di
Published: June 2023

Aim: More than two years after the beginning of the global pandemic period, most governments have adopted questionable strategies, aimed at the progressive reduction of people freedom and pushing in non-transparent way on the forced use of genic drugs, improperly called vaccines. The purpose of this work concerns the different way in which news relating to pandemic reached italian people by traditional media (main TV channels and main national newspapers) and by social media, in particular Telegram. Methods: The paper considers the situation perceived in Italy up to the first months of 2022 by analyzing the news appearing on mainstream TV channels and how they are described by national newspapers, as opposed to what can be deduced from some social media platforms who are still enough free from a clear process of censorship. Results: The analysis underlines that there is a macroscopic discrepancy between traditional and social media; the official narration of the traditional media is not only questionable, but does not give rise to the possibility of a free discussion on the hottest issues of this pandemic. Only Telegram appears to be the most censorship free channel among the studied traditional/ social media in this paper. Conclusion: The attention placed on the official narrative of Covid-19, on the use of the methodology still in force in Italy for fighting the pandemic, on the strong non-sanitary limitation of individual freedom and on a possible underlying plan about what is globally happening, leads to the conclusion that in Italy there is an attempt to give an ambiguous, equivocal and inconsistent version of the facts, contradicted by experimental data and scientific papers appearing more and more numerous in qualified international journals.
A Review on Grip and Pinch Strength Tests
Authors: M Mohammadian
Published: June 2023

Grip strength measurement data has many applications in health assessment and ergonomic strategies. However, this issue has been neglected by wellness researchers and activists in Iran. Therefore, this study was designed to review the factors affecting grip strength, the protocol and tools necessary for grip strength tests, the validity and reliability of grip strength tests, as well as the databases and forward-looking equations of grip strength. This is a review study. The required information was obtained by searching the International Information Banks of Science Direct, Web of Science, Scopus, Springer, ProQuest, Google Scholar and PubMed (between 1980to2022). Search keywords were "hand strength, grip strength, pinch strength, normative data, dynamometer, regression models, and anthropometric measurements". One hindered and forty relevant articles were found in total 45 of them were reviewed and finally used in this study. In this study, effective demographic and anthropometric factors, measurement instruments, test protocols, validity and reliability of measurement, principles of creating databases of grip strength, and also forward-looking models of these databases were reviewed and results were presented. The measurement of grip strength is performed with the purpose of investigating upper limb disorders, designing hand tools, designing workstations, and determination of the improvement level of different treatments. Demographic characteristics and anthropometric factors, particularly the upper anthropometric dimensions, affected the grip strength. Researchers, ergonomists, therapists, and physicians can benefit from the results of this study
Steering Geometry of Remote Control Agricultural Vehicle
Authors: R Yadav
Published: June 2023

For any vehicle, steering mechanism is important one, in this research discuss importance of steering mechanism, what kind of steering mechanism used. For designing Unmanned remote control agricultural vehicle is rear wheel drive vehicle and front wheel is used for steer or turn the vehicle, but challenge for designing this type of vehicle is that unmanned remote control agricultural vehicle is not only working in flat road surface but it’s also used in agricultural field also. Another challenge was to working of steering system very fluently and reliable for farmer. The maximum steering effort was found 101.53 N for single wheel and angle for inner and outer wheel was 45.24° and 30.74° respectively. We have also found the turning radius of vehicle was 1490 mm.
Treating SARS-CoV-2 Based Upon the Fleming InflammoThrombotic Response (ITR) & Cardiovascular Disease Theory
Authors: Fleming Richard M
Published: June 2023

This paper discusses the importance of addressing, measuring and treating the infectious, inflammatory and thrombotic tissue effect resulting from the body’s immunologic response to SARS-CoV-2 using methods previously detailed in the medical literature, in an effort to reduce SARS-CoV-2 morbidity and mortality. Successful treatment of SARS-CoV-2 requires addressing each of the four stages of the viral infection including oxygenation, acute cytotoxic immune response, adaptive humoral-antibody response, and viral cellular attachment and replication. Information obtained from the National Clinical Trial NCT04349410 has proven the benefit of treating each of these four factors. A paper detailing the NCT04349410 results has been published elsewhere.
Abnormal Chromosome in Patients with Multiple Myeloma: A Cohor Study in Vietnam
Authors: Tuan Tung Nguyen
Published: June 2023

Objective: To identify some common chromosomal mutation in patients with Multiple myeloma (MM) at Bach Mai hospital, from June 2016 to June 2021. Methods: We reviewed the cytogenetic results from 363 patients who were diagnosed with MM by IMWG diagnostic criteria 2014 at Bach Mai hospital. Results: Chromosomal abnormalities were detected in 35,3% (128/363) of the patients. Among these results, 128 cases (82,8%) had both numerical and structural chromosome abnormalities. Hyperdiploidy with structural cytogenetic aberrations was the most common finding (42,19%), followed by hypodiploidy with structural aberrations (23,44%). Amplification of the long arm of chromosome 1, loss 13/ del(13q) and abnormality involving 14q32 were the most frequent abnormalities which were observed in 39,84%, 24,2% and 21,9%. The most common numerical abnormalities were gains of chromosomes 9 with 28,57%.
Complications and Associations in a Multiple Myeloma Cohort at Presentation
Authors: Madu Anazoeze Jude
Published: June 2023

Background: Myelomatosis accounts for about 10% of haematological malignancies according to previous studies in different climes. The impact of some complications on treatment choice as well as survival outcomes is significant and worthy of study. Aims: To describe complications observed at presentation in this cohort of myeloma patients and to assess the associations of these complications with certain laboratory and clinical parameters. Results: There were 37 males and 29 females, median age 61 years (Range 37-85). Median values at presentation was Hb - 8g/dL, serum albumin 37 mg/dL and calcium 2.5 mmol/L. Bence Jones proteinuria was present in 50% (17/34), majority (78.8% -26/33) had IgG myeloma and 7 (21.2%) IgA. They had nephropathy 19% (4/21), osteolytic lesions 34.7% (17/49), pathological fractures 56.1% (23/41), anaemia 91.4% (53/58) and hypercalcaemia 42% (21/50). commonest presenting symptom was bone pain in 87.2% (48/55). There was significant correlation between hypercalcaemia and haematocrit (r=0.338, p=0.039) and platelet count (r= 0.331, p= 0.029). No relationship was found between hypercalcaemia and beta -2 microglobulin (r= 0.046, p= 0.0834) or serum immunoglobulin (r= -0.071, p= 0.745). Pathological fractures showed no significant association with haematocrit (r= -0.137, p= 0.453), platelet (r= -0.097, p= 0.642), beta -2 microglobulin (r= -0.037, p= 0.865) and serum immunoglobulin (r= -0.132, p= 0.545). Chi square value for the occurrence of renal Impairment and hypercalcaemia was found to be significant r= 8.048, p= 0.007 as well as pathological fractures (r=8.048, p=0.005). Conclusions: Myeloma is prevalent in males 1.5:1. Bone pain and anaemia are the commonest features at presentation. Bence Jones proteinuria is only seen in about half of the patients and lytic lesions in about a third. Pathological fractures, anaemia or hypercalcaemia at presentation, were not associated with tumor stage (β-2 microglobulin and albumin levels). Significant association exists between the occurrence of renal impairment and pathological fractures.
Intra-thyroid Metastasis Revealing Bronchial Cancer
Authors: F Kamel
Published: June 2023

Thyroid metastases are rare. They may exceptionally reveal the primary cancer. Several hypotheses have been proposed to explain the low rate of thyroid metastases. The diagnosis is sometimes difficult to establish because the lesions are most often asymptomatic. Ultrasound and scanner are not specific. Histological examination and immune histochemical analysis is the key to diagnosis. Curative management depends on the histological type and the resect ability of the primary tumor. We report the case of a patient who presented with cervical swelling associated with dysphonia; clinical examination found a thyroid nodule confirmed by cervical ultrasound associated with a forearm mass. The patient underwent a left isthmolobectomy and then a right totalization. Histological examination was in favor of an intra-thyroid metastasis of an adenocarcinoma of pulmonary origin. The extension work-up showed pulmonary nodules and bone metastases. The patient underwent chemotherapy with good progression. Finally, the diagnosis of thyroid metastases must always be evoked in front of a swelling of the thyroid gland especially in the presence of a history of neoplasia.
Significance of Chromogranin A and Synaptophysin in Parathyroid Proliferative Lesions: Immunohistochemical Study on Parathyroid Adenoma, Atypical Adenoma, Carcinoma and Hyperplasia
Authors: Tomita Tatsuo
Published: June 2023

By immunostaining for chromogranin A, synaptophysin and parathyroid hormone, parathyroid proliferative lesions were compared by immunostaining patterns from normal parathyroid glands. Immunohistochemical staining for chromogranin A, synaptophysin and parathormone was performed with normal glands and proliferative lesions including 13 parathyroid adenomas, one atypical adenoma, two carcinoma and eight hyperplasia cases. Proliferating parathyroid lesions including adenoma, atypical adenoma and hyperplasia were less immunosatained for parathyroid hormone and chromogranin A than normal parathyroids. Two carcinoma cases were diffusely positive for parathyroid hormone but weakly positive for chromogranin. All normal parathyroid glands and the majority of parathyroid proliferative lesions were negatively immunostained for synaptophysin. This weakly immunostained CgA in parathyroid proliferative lesions supports autonomous parathormone and chromogranin A secretion, resulted in lesser stored parathormone in chromogranin A-containing secretory granules. Atypical adenoma case was less immunostained for parathyroid hormone and chromogranin A like the other adenomas while two carcinomas were diffusely positive for parathyroid hormone and weakly positive for chromogranin A. This different parathormone immunosataining patterns may distinguish between atypical adenoma and carcinoma. Normal glands and the majority of proliferative lesions were negative for synaptophysin and synaptophysin may not be directly involved in synthesis and secretion of parathormone in normal and proliferative parathyroid lesions.
Chemicals that Disrupt the Endocrine System and their Effects on Human Health
Authors: Khan Yousaf
Published: June 2023

Endocrine glands are the important glands of human that performs certain functions and has specific characteristics. The main function of these glands is that they regulate the whole system by producing hormones which they produce indigenously and pours them directly in the blood for a targeted action and all of their functions are involuntary. They are specifically ductless glands and their course of action is regulated by a pea size Pituitary gland or sometimes referred as the Master Gland. Until now, very less has been known about these glands that their actions or functions are being interrupted or disturbed by chemicals or other environmental actions. There are certain chemicals which include chlorpyrifos, DDT, insecticides, pesticides, fungicides and other daily use items such as plastics, paints, furniture, perfumes, toys polishes, electronic gadgets, items of food packaging are reported to have disturbed the normal hormonal functions in humans that are leading to numerous diseases due to either lack of production of specific hormone or increased production of a specific hormone by the action of these chemicals. The diseases that are commonly reported due to the action of the above chemicals and daily use items includes neurological disorders, behavioral disorders, metabolic dysfunction leading to obesity or weakness, thyroid dysfunction, reproductive disturbances and several others that can prove fatal and lead to cancer as well.
Menstrual Problems among Adolescent Girls and Female Youth in Tamil Nadu
Authors: kumar A Ranjith
Published: June 2023

Menstruation, or period, is normal vaginal bleeding that happens as a part of a woman’s monthly cycle. The menstrual cycle is that the hormonal process a woman’s body goes through monthly to get ready for a possible pregnancy. Regular menstrual periods within the years between puberty and menopause are usually a sign that the body is functioning normally. Irregular or heavy, painful periods are not normal. Many women get premenstrual syndrome (PMS) symptoms. It encompasses the foremost common issues, like mild cramping and fatigue, but the symptoms usually get away when the period begins. Menstruation that is too heavy or too light, or the entire absence of a cycle, may suggest that other issues are contributing to an abnormal menstrual cycle. Menstrual hygiene plays an important role in the health of young women. This study focuses on menstrual problems among adolescent girls. The main objectives of the present study are; to find out the awareness regarding menstrual problems among adolescent girls, and to investigate the problems about menstruation among adolescent girls.
Awareness of Women about Tetanus in Baghdad
Authors: AA Salih
Published: June 2023

Background: Tetanus toxoid (TT) vaccine is still recommended for pregnant women even in countries that declared elimination of neonatal tetanus (NT) and consequently the maternal tetanus (MT). Many factors may affect TT vaccination during pregnancy. Awareness is a key factor that greatly affect the pregnant women to receive tetanus toxoid vaccination during pregnancy. Aims of study: To assess the awareness of women regarding different aspects of tetanus and tetanus toxoid vaccination as well as to identify the factors influencing their awareness. Subjects and Method: A cross sectional study conducted in Baghdad from first of April to the end of September 2021. Convenient sample of women in reproductive age, attended the designated primary health care centers for the study were enrolled. An interview questionnaire was used to collect quantitative data pertaining to awareness of women about tetanus toxoid immunization and tetanus infection. The total number of women enrolled in the study was 400, the study found that that 35.2% and 35% of women had good and fair level of awareness respectively. Good awareness level was significantly higher among older aged women and those with higher level of education as well as working women. Good awareness was more prominent among women’s having1-2 children (39%), as compared to those having five and more children (21.3%). Antenatal care attendance and place of delivery shown statistical significant link with level of awareness. Women identify family members and friends as their primary sources of information about tetanus infection and immunization. Conclusion: Women’s awareness was acceptable regarding Tetanus and TT immunization. Yet still there is a place for proper health education targeting young women to bridge gap in the connection between the etanus immunization status of women and the occurrence of Maternal neonatal tetanus (MNT), as well as need for the appraisal of the components of health information delivered by health care providers to women attending antenatal care clinics.