bluuebunny/crossref_metadata_2025 huggingface dataset:
Broadband High‐Efficiency Chiral Splitters and Holograms from Dielectric Nanoarc Metasurfaces
Authors: Wang Dapeng , Hwang Yongsop , Dai Yanmeng , Si Guangyuan , Wei Shibiao , Choi Duk‐Yong , Gómez Daniel E. , Mitchell Arnan , Lin Jiao , Yuan Xiaocong
Published: April 2019

Simultaneous broadband and high efficiency merits of designer metasurfaces are currently attracting widespread attention in the field of nanophotonics. However, contemporary metasurfaces rarely achieve both advantages simultaneously. For the category of transmissive metadevices, plasmonic or conventional dielectric metasurfaces are viable for either broadband operation with relatively low efficiency or high efficiency at only a selection of wavelengths. To overcome this limitation, dielectric nanoarcs are proposed as a means to accomplish two advantages. Continuous nanoarcs support different electromagnetic resonant modes at localized areas for generating phase retardation. Meanwhile, the geometric nature of nanoarc curvature endows the nanoarcs with full phase coverage of 0–2π due to the Pancharatnam–Berry phase principle. Experimentally incorporated with the chiral‐detour phase principle, a few compelling functionalities are demonstrated, such as chiral beamsplitting, broadband holography, and helicity‐selective holography. The continuous nanoarc metasurfaces prevail over plasmonic or dielectric discretized building block strategies and the findings lead to novel designs of spin‐controllable metadevices.
Predictive value of soluble urokinase-type plasminogen activator receptor for mortality in patients with suspected myocardial infarction
Authors: Sörensen Nils A. , Nikorowitsch Julius , Neumann Johannes T. , Rübsamen Nicole , Goßling Alina , Hartikainen Tau S. , Blankenberg Stefan , Westermann Dirk , Zeller Tanja , Karakas Mahir
Published: April 2019

Background

Early risk stratification of patients with suspected acute myocardial infarction (AMI) constitutes an unmet need in current daily clinical practice. We aimed to evaluate the predictive value of soluble urokinase-type plasminogen activator receptor (suPAR) levels for 1-year mortality in patients with suspected AMI.

Methods and results

suPAR levels were determined in 1314 patients presenting to the emergency department with suspected AMI. Patients were followed up for 12 months to assess all-cause mortality. Of 1314 patients included, 308 were diagnosed with AMI. Median suPAR levels did not differ between subjects with AMI compared to non-AMI (3.5 ng/ml vs. 3.2 ng/ml, p = 0.066). suPAR levels reliably predicted all-cause mortality after 1 year. Hazard ratio for 1-year mortality was 12.6 (p < 0.001) in the quartile with the highest suPAR levels compared to the first quartile. The prognostic value for 6-month mortality was comparable to an established risk prediction model, the Global Registry of Acute Coronary Events (GRACE) score, with an AUC of 0.79 (95% CI 0.72–0.86) for the GRACE score and 0.77 (95% CI 0.69–0.84) for suPAR. Addition of suPAR improved the GRACE score, as shown by integrated discrimination improvement statistics of 0.036 (p = 0.03) suggesting a further discrimination of events from non-events by the addition of suPAR.

Conclusions

suPAR levels reliably predicted mortality in patients with suspected AMI.

Study registration

http://www.clinicaltrials.gov (NCT02355457).
School absenteeism as a risk factor for self-harm and suicidal ideation in children and adolescents: a systematic review and meta-analysis
Authors: Epstein Sophie , Roberts Emmert , Sedgwick Rosemary , Polling Catherine , Finning Katie , Ford Tamsin , Dutta Rina , Downs Johnny
Published: April 2019

Self-harm and suicidal ideation in children and adolescents are common and are risk factors for completed suicide. Social exclusion, which can take many forms, increases the risk of self-harm and suicidal ideation. One important marker of social exclusion in young people is school absenteeism. Whether school absenteeism is associated with these adverse outcomes, and if so to what extent, remains unclear. To determine the association between school absenteeism and both self-harm (including completed suicide) and suicidal ideation in children and adolescents, we conducted a systematic review of observational studies. We conducted meta-analysis and report a narrative synthesis where this was not possible. Meta-analysis of cross-sectional studies showed that school absenteeism was associated with an increased risk of self-harm [pooled adjusted odds ratio (aOR) 1.37, 95% confidence interval 1.20–1.57,P = 0.01] and of suicidal ideation (pooled aOR 1.20, 95% CI 1.02–1.42,P = 0.03). A small number of studies showed that school absenteeism had a longitudinal association with both adverse outcomes. Heterogeneity in the exposure and outcome variables, study design and reporting was prominent and limited the extent to which it was appropriate to pool results. School absenteeism was associated with both self-harm and suicidal ideation in young people, but this evidence was derived from a small number of cross-sectional studies. Further research into the mechanisms of this association could help to inform self-harm and suicide prevention strategies at clinical, school and population levels.
Visualizing faculty development impact: A social network analysis
Authors: Foo Yang Yann , Moody James , Cook Sandy
Published: April 2019

Faculty development programs have tended to focus on low levels of evaluation such as participant satisfaction rather than assess the actual changes that training has brought about in the workplace. This has prompted scholars to suggest using social network analysis as a means to provide a more rigorous method of evaluating the impact of faculty development. To test the feasibility of such a suggestion, we used the social network analysis concepts of social cohesion to assess the impact of a year-long fellowship program conducted by Duke-NUS Medical School’s Academic Medicine Education Institute (AM·EI). Specifically, we used the key metrics of connectedness and betweenness centrality to assess the changes in the AM·EI fellows’ information and collaboration networks post-fellowship. We invited three cohorts of AM·EI fellows (2013–2016; n = 74) to participate in a branched survey. The response rate was 64%; n = 47. Results showed that in terms of connectedness, the largest connected set more than doubled in size, and pair level reachability grew threefold. Betweenness centrality among the AM·EI fellows also increased, with more individuals reporting that they sought advice from the fellows as well as trusted the advice the fellows provided. In sum, this study suggests that it is indeed viable to use social network analysis to identify changes in social cohesion. As such, social network analysis serves as another tool for scholars to use to assess the impact of their faculty development efforts.
The specialization curse: How economic specialization shapes public goods provision
Authors: Barber Benjamin , Mazaheri Nimah
Published: April 2019

This paper examines the relationship between economic specialization and government expenditures. We hypothesize that citizens and firms in economically specialized regions pressure politicians to invest in core economic sectors in lieu of spending on public goods that benefit the broader economy, such as education. We investigate our hypothesis through an examination of the United States and India. We confirm a negative relationship between economically specialized U.S. states and education spending, and a positive relationship between economically specialized U.S. states and firm subsidies. Next, we examine the effects of an immediate shock in a region's level of economic specialization by comparing Indian states created from federal bifurcation. We show how the creation of two highly specialized states (Bihar and Jharkhand) from a diversified state (Undivided Bihar) was associated with a decline in education spending but an increase in subsidies for core sectors.
Nonlinear exact coherent structures in pipe flow and their instabilities
Authors: Ozcakir Ozge , Hall Philip , Tanveer Saleh
Published: April 2019

In this paper, we present computational results of some two-fold azimuthally symmetric travelling waves and their stability. Calculations over a range of Reynolds numbers ($Re$) reveal connections between a class of solutions computed by Wedin & Kerswell (J. Fluid Mech., vol. 508, 2004, pp. 333–371) (henceforth called the WK solution) and the $Re\rightarrow \infty$ vortex–wave interaction theory of Hall & Smith (J. Fluid Mech., vol. 227, 1991, pp. 641–666) and Hall & Sherwin (J. Fluid Mech., vol. 661, 2010, pp. 178–205). In particular, the continuation of the WK solutions to larger values of $Re$ shows that the WK solution bifurcates from a shift-and-rotate symmetric solution, which we call the WK2 state. The WK2 solution computed for $Re\leqslant 1.19\times 10^{6}$ shows excellent agreement with the theoretical $Re^{-5/6}$, $Re^{-1}$ and $O(1)$ scalings of the waves, rolls and streaks respectively. Furthermore, these states are found to have only two unstable modes in the large $Re$ regime, with growth rates estimated to be $O(Re^{-0.42})$ and $O(Re^{-0.92})$, close to the theoretical $O(Re^{-1/2})$ and $O(Re^{-1})$ asymptotic results for edge and sinuous instability modes of vortex–wave interaction states (Deguchi & Hall, J. Fluid Mech., vol. 802, 2016, pp. 634–666) in plane Couette flow. For the nonlinear viscous core states (Ozcakir et al., J. Fluid Mech., vol. 791, 2016, pp. 284–328), characterized by spatial a shrinking of the wave and roll structure towards the pipe centre with increasing $Re$, we continued the solution to $Re\leqslant 8\times 10^{6}$ and we find only one unstable mode in the large Reynolds number regime, with growth rate scaling as $Re^{-0.46}$ within the class of symmetry-preserving disturbances.
Humics—Their History in the Radiocarbon Intercomparison Studies
Authors: Naysmith Philip , Scott E Marian , Dunbar Elaine , Cook Gordon T
Published: April 2019

Over the past 30 years, the format of the radiocarbon (14C) intercomparison studies has changed, however, the selection of sample types used in these studies has remained constant—namely, natural and routinely dated materials that could subsequently be used as in-house reference materials. One such material is peat which has been used 12 times, starting with the ICS in 1988. Peat from Iceland (TIRI), Ellanmore (TIRI), Letham Moss (ICS, VIRI, and SIRI), and St Bees, UK (FIRI and VIRI) have been used, as well as a near-background peat from Siberia. In the main, these peat samples have been provided as the humic acid fraction, with the main advantage being that the humic acid is extracted in solution and then precipitated (the solution phase providing the homogenisation) which is a key requirement for a reference material. In this paper, we will revisit the peat results and explore their findings. In addition, for the last 8 years, the Letham Moss sample has been used in the SUERC 14C laboratory as an in-house standard or reference material. This has resulted in several thousand measurements. Such a rich data set is explored to illustrate the benefits arising from the intercomparison program.
SURVEY AND SAMPLING AT THE CASTLE DYKES IRON AGE ‘HENGE’, WENSLEYDALE, NORTH YORKSHIRE
Authors: Gibson Alex , Neubauer Wolfgang , Flöry Sebastian , Schneidhofer Petra , Allen Mike , Allison Enid , Carruthers Wendy , Challinor Dana , French Charles , Rushworth Garry , Sheridan Alison
Published: April 2019

Survey and sampling at the classic single-entranced henge monument at Castle Dykes, in North Yorkshire, has revealed traces of circular timber structures, interpreted as later prehistoric roundhouses, in the immediate vicinity and within the henge. Coring of the waterlogged silts of the internal ditch has produced considerable environmental data: plant, insect, pollen and charcoal remains. A small jet bead was also recovered. Radiocarbon dates from short-lived materials unexpectedly indicate that the monument was constructed in the Iron Age, which prompts a review of other potentially Iron Age ‘henges’ further afield.
From Moses to Moses: Anthropomorphism and Divine Incorporeality in Maimonides’s Guide and Mendelssohn’s Bi’ur
Authors: Sackson Adrian
Published: April 2019

Moses Mendelssohn, arguably the founding figure of modern Jewish philosophy, famously quipped that it was the hours of his youth spent studying the philosophical work of another Moses—Moses Maimonides—that left him with his famously crooked posture. This study investigates one important aspect of the relationship between Mendelssohn and Maimonides: their respective attitudes toward anthropomorphic language in the Bible. Much of the first part of Maimonides’s Guide of the Perplexed is devoted to reinterpretation of scriptural language in light of Maimonides’s non-anthropomorphic, incorporeal conception of God. These chapters constitute a central plank of Maimonides’s religious agenda. Like Maimonides, Mendelssohn was both a philosopher and a religious Jew. His most extensive project intended for a Jewish audience was his German translation of the Pentateuch, accompanied by a Hebrew commentary, known as the Bi’ur. This study examines the manner in which Mendelssohn saw fit to interpret precisely the same set of biblical terms selected by Maimonides for philosophical reinterpretation. Through an investigation of Mendelssohn’s approach to anthropomorphism, divine incorporeality, and philosophical reinterpretation in the biblical commentary, I hope to shed light on an important dimension of the nature of his engagement with Maimonides.
A novel endoscopic hydro-mastoidectomy technique for transcanal endoscopic ear surgery
Authors: Nishiike S , Oshima K , Imai T , Uetsuka S
Published: April 2019

Background

In order to remove a cholesteatoma in the mastoid under transcanal endoscopic ear surgery, it is necessary to perform transcanal endoscopic mastoidectomy. Bone dust and blood, however, obscure the surgical field. A novel endoscopic hydro-mastoidectomy technique was developed, in which the operator performs the mastoidectomy ‘underwater’ using a lens cleaning system that provides saline perfusion in the surgical space.

Methods

A curved round coarse diamond bur is attached to an otological drill. A lens cleaning sheath is fitted to the endoscope. The surgeon controls the infusion of saline solution by stepping on a footswitch of the power console.

Results

Endoscopic hydro-mastoidectomy washes out bone dust and blood from the surgical field, improving the surgical view during mastoidectomy. Additionally, the operator can easily control the flow of saline perfusion.

Conclusion

This technique provides a clear surgical view by washing out bone dust and blood from the surgical area. The setup for endoscopic hydro-mastoidectomy technique is easy and the operator needs only to buy sheaths if they already own the power console, as many otological and rhinological surgeons do.
Rehabilitation following open partial laryngeal surgery: key issues and recommendations from the UK evidence based meeting on laryngeal cancer
Authors: Dawson C , Pracy P , Patterson J , Paleri V
Published: April 2019

Background

It is recognised that a limited cohort of patients receive open partial laryngeal surgery in specific centres within the UK, so sharing information around key clinical issues and recommendations for practice is necessary to improve outcomes.

Methods

This position statement provides practice recommendations based on a synthesis of the available evidence presented at the 12th Evidence Based Management day on ‘Laryngeal Cancer’ and the ensuing discussions. Literature searches and critical analysis of available evidence were undertaken and triangulated with the clinical experience of the authors to develop these recommendations.

Results and conclusion

This paper presents a comprehensive overview of challenges that the multidisciplinary team may encounter. It provides recommendations for swallow and speech rehabilitation after open partial laryngectomy, and suggests practical ways that these issues may be addressed pre- and post-operatively.
Improved methods for reducing translocation mortality and obtaining reliable population projections for reintroduction of the New Zealand Rifleman Acanthisitta chloris
Authors: WITHERS SARAH , ARMSTRONG DOUG , WARD-SMITH TAMSIN , PARSONS STUART , HAUBER MARK E.
Published: April 2019

Despite many notable successes, the failure rate of animal translocations remains high. Conservation practitioners and reintroduction specialists have emphasised the need for ongoing documentation of translocation attempts, whether successful or not, including detailed methodologies and monitoring approaches. This study reports on the first translocation of the North Island subspecies of New Zealand’s smallest bird, the endemic Rifleman Acanthisitta chloris granti. We describe an improved transfer methodology following recommendations arising from a previous translocation of South Island Rifleman Acanthisitta chloris chloris. Key modifications included a reduced capture window, shorter holding times, lack of extended aviary housing, and separation of territorial individuals during holding. Survival from capture to release increased from 52% to 97% using this new methodology. However, only 22% of 83 released birds were found in the reserve the next breeding season, resulting in an initial breeding population of only six males and five females. An integrated Bayesian analysis of three years of subsequent population data, including a population boost from a second translocation, projected a median decrease to 0–5 females over 10 years, but with 95% prediction intervals ranging from 0 to 33. These projections explicitly account for parameter uncertainty, as well as demographic stochasticity, and illustrate the need to do so when making inferences for small reintroduced populations.
Weighted counting of solutions to sparse systems of equations
Authors: Barvinok Alexander , Regts Guus
Published: April 2019

Given complex numbers w1,…,wn, we define the weight w(X) of a set X of 0–1 vectors as the sum of $w_1^{x_1} \cdots w_n^{x_n}$ over all vectors (x1,…,xn) in X. We present an algorithm which, for a set X defined by a system of homogeneous linear equations with at most r variables per equation and at most c equations per variable, computes w(X) within relative error ∊ > 0 in (rc)O(lnn-ln∊) time provided $|w_j| \leq \beta (r \sqrt{c})^{-1}$ for an absolute constant β > 0 and all j = 1,…,n. A similar algorithm is constructed for computing the weight of a linear code over ${\mathbb F}_p$. Applications include counting weighted perfect matchings in hypergraphs, counting weighted graph homomorphisms, computing weight enumerators of linear codes with sparse code generating matrices, and computing the partition functions of the ferromagnetic Potts model at low temperatures and of the hard-core model at high fugacity on biregular bipartite graphs.
Links between sexuality, impulsivity, compulsivity, and addiction in a large sample of university students
Authors: Blum Austin W. , Lust Katherine , Christenson Gary , Grant Jon E.
Published: April 2019

Objective.

Non-heterosexual populations experience poorer mental health outcomes than their heterosexual counterparts. Few studies, however, have examined how mental health varies across the continuum of sexual orientation. Nor has any study examined possible links between sexual orientation and traits of impulsivity and compulsivity, which contribute to functional impairment across a broad spectrum of psychiatric disorders. To address these limitations, the present study sought to identify addictive and impulsive/compulsive problems associated with sexuality in a university sample.

Methods.

A 156-item anonymous survey was distributed via email to 9449 students at a public university in the United States. Sexual orientation was assessed using the Klein Sexual Orientation Grid, a modification of the Kinsey scale. Current use of alcohol and drugs, mental health status, and academic performance were also assessed, along with valid trait measures of impulsivity and compulsivity.

Results.

Same-sex attractions were significantly correlated with a range of mental health problems and substance use. Additionally, same-sex attraction was significantly correlated with certain behavioral addictions (compulsive sexual behavior and binge eating disorder) as well as impulsive/compulsive traits. There was no relationship between academic performance and sexual attraction.

Conclusion.

Same-sex sexuality is associated with impulsive/compulsive behavior and addiction. These health disparities may be related to stable individual differences in self-control.
Neurocognitive predictors of metacognition in individuals at clinical high risk for psychosis
Authors: Shakeel M.K. , Lu L. , Woods S.W. , Perkins D.O. , Addington J.
Published: April 2019

Background:

Metacognition refers to the ability to evaluate and control our cognitive processes. While studies have investigated metacognition in schizophrenia and clinical high risk for psychosis (CHR), less is known about the potential mechanisms which result in metacognitive deficits.

Aims:

We aimed to investigate whether neurocognitive functions including attention, working memory, verbal learning and executive functions predicted the tendency to focus on one’s thoughts (cognitive self-consciousness) and beliefs in the efficacy of one’s cognitive skills (cognitive confidence).

Method:

Participants (130 CHR individuals) were recruited as part of the multi-site PREDICT study. They were assessed using the Metacognitions Questionnaire (MCQ) as well as measures of executive function (WCST), attention (N-Back), working memory (LNS) and verbal learning (AVLT).

Results:

Cognitive competence was negatively correlated with N-Back while cognitive self-consciousness was positively correlated with N-Back and LNS. Linear regression analysis with N-Back, AVLT, LNS and WCST as predictors showed that neurocognition significantly predicted cognitive self-consciousness, with N-Back, LNS and WCST as significant predictors. The model accounted for 14% of the variance in cognitive self-consciousness. However, neurocognition did not result in a significant predictive model of cognitive competence.

Conclusions:

Neurocognition was associated with an increased focus on one’s thoughts, but it was not associated with higher confidence in one’s cognitive skills. Neurocognition accounted for less than one-sixth of the variance in metacognition, suggesting that interventions that target neurocognition are unlikely to improve metacognitive abilities.
On the Etymology of GothicAlew
Authors: Pagliarulo Giuseppe
Published: April 2019

Gothicalew‘oil’ is ultimately derived from Latinoleum. Its phonological features, however, seem hardly reconcilable with those of the Latin word. This has prompted scholars to postulate that the Latin word was not borrowed directly into Gothic but rather via a third language: continental Celtic, Illyrian or Raetic. This article examines the weaknesses of these theories and proposes that the unexpected features of the Gothic item may be explained in terms of proper Gothic or Latin developments, making direct derivation ofalewfromoleumthe most plausible and parsimonious hypothesis.
Dimming the Seas around Borneo: Contesting Island Sovereignty and Lighthouse Administration amidst the End of Empire, 1946–1948
Authors: Saunders David R.
Published: April 2019

This article examines issues of island sovereignty and lighthouse administration in maritime Southeast Asia in the context of post-war decolonisation. It does so by demonstrating how lax and complacent colonial governance in British North Borneo led to the construction of a lighthouse on contested island territory. By the late 1940s these islands became the focal point of a regional dispute between the Philippines, North Borneo's colonial government, and the United Kingdom. While lighthouses were, in the colonial mind-set, deemed essential for illuminating the coasts and projecting order onto the seas, the Philippine government sought to renege on colonial-era obligations and wrest a new sense of post-colonial legitimacy.

The legacy of the Turtle Island transfer was therefore significant in recalibrating imperial lighting in the Sulu Sea, as well as giving rise to a Philippine post-colonial authority that was characterised by an acknowledgement of indigenous Suluk maritime heritage. Similarly, it reflected an extension of previous instances of transnational disputes in the region, where the island shoal had been simultaneously claimed and administered by the United States, the United Kingdom and the historical Sulu Sultanate. While the lighthouse remained destroyed, and the seas dimmed, by mid-1948 the Turtle Islands had attained a new post-colonial and transnational status. Utilising a range of archival sources, memoirs and published material, this article sheds light on an under-examined period of Southeast Asian history.
The effect of L-arginine supplementation on obesity-related indices: A systematic review and meta-analysis of randomized clinical trials
Authors: Mousavi Seyed Mohammad , Milajerdi Alireza , Fatahi Somaye , Rahmani Jamal , Zarezadeh Meysam , Ghaedi Ehsan , Varkaneh Hamed Kord
Published: April 2019

Abstract. The clinical studies regarding the effect of L-arginine in human anthropometry have not been fully consistent, therefore, we carried out a systematic review and meta-analysis of randomized clinical trials in order to precisely evaluate and quantify the efficacy of L-arginine on weight, waist circumference, and BMI. We searched online databases including PubMed, SCOPUS, and Google Scholar for relevant articles up to September 2017. Eligible articles were reviewed by two independent investigators. Mean differences of the outcomes were used for calculation of weighted mean difference (WMD) derived from the random-effects model. Statistical heterogeneity between studies was examined using Cochran’s Q-test and I 2 index. Funnel plot and Egger’s tests were performed to assess the publication bias. In our initial search, we found 1598 publications, of which 8 RCTs (9 treatment arms) were included. The results of the meta-analysis displayed a significant reduction in WC following L-arginine supplementation (WMD: −2.97 cm; 95% CI: −4.75 to −1.18, P = 0.001). However, L-arginine intervention had not elicited a significant effect on BMI (WMD: −0.51 kg/m2; 95% CI: −1.11 to .08, P = 0.09) and body weight (WMD: −0.57 kg; 95% CI: −1.77 to 0.61, P = 0.34). Subgroup analyses displayed that longer-term interventions (≥8 weeks) had a positive effect on body weight and using < 8 g/day L-arginine with longer duration (≥8 weeks) could significantly decrease BMI. In conclusion, this meta-analysis result suggested L-arginine supplementation could reduce waist circumference without any significant effect on body weight and body mass index.
Synbiotic supplementation is not effective on breast milk selenium	concentrations and growth of exclusively breast fed infants: a pilot	study
Authors: Nikniaz Leila , Mahavi Reza , Ostadrahimi Alireza , Nikniaz Zeinab , Taghipour Sharare
Published: April 2019

Abstract. In this randomized, double-blind, placebo-controlled trial, 57 lactating mothers were randomly allocated into two groups to receive a daily supplement of synbiotic (n = 30) which contained different probiotic strains (2.0 × 108 CFU) and fructooligosaccharide (394 mg) or a placebo (n = 27) for 30 days. Dietary intake was collected from lactating women by 24-hour recall method. Breast milk selenium contents were determined by atomic absorption spectrometry with graphite furnace. Weight for age Z-score (WAZ) and Height for age Z-score (HAZ) were evaluated for infants. Data analyses were assessed using nutritionist IV, Epi Info and SPSS software and presented as mean ± sd or SEM. The total mean breast milk selenium levels were 50.1 ± 16.1 mcg L−1. At the baseline, the mean breast milk selenium concentrations in the synbiotic and placebo groups were 51.7 ± 20.2 and 48.5 ± 12.1 mcg L−1. The mean breast milk selenium levels increased and decreased in the symbiotic and placebo groups respectively, which were not significant (p > 0.05). Also, comparison of the changes in breast milk selenium concentration showed no significant difference between the two study groups after the intervention. At the baseline, the mean WAZ and HAZ of infants whose mothers’ milk selenium was more than 60 mcg/l was significantly (P < 0.05) higher than for others. In this pilot study, no significant effect was observed by synbiotic supplementation, however, for concise conclusion, more human studies with higher doses of supplements and longer duration of supplementation are needed to determine the effects of synbiotic supplementation on breast milk selenium contents and infants’ growth.
The Response of Permafrost and High‐Latitude Ecosystems Under Large‐Scale Stratospheric Aerosol Injection and Its Termination
Authors: Lee Hanna , Ekici Altug , Tjiputra Jerry , Muri Helene , Chadburn Sarah E. , Lawrence David M. , Schwinger Jörg
Published: April 2019

Climate engineering arises as one of the potential methods that could contribute to meeting the 1.5 °C global warming target agreed under the Paris Agreement. We examine how permafrost and high‐latitude vegetation respond to the large‐scale implementation of climate engineering. Specifically, we explore the impacts of applying the solar radiation management method of stratospheric aerosol injections (SAI) on permafrost temperature and the global extent of near‐surface permafrost area. We compare the RCP8.5 and RCP4.5 scenarios to several SAI deployment scenarios using the Norwegian Earth System Model (CE1 = moderate SAI scenario to bring down the global mean warming in RCP8.5 to the RCP4.5 level, CE2 = aggresive SAI scenario to maintain the global mean temperature toward the preindustrial level). We show that large‐scale application of SAI may help slow down the current rate of permafrost degradation for a wide range of emission scenarios. Between the RCP4.5 and CE1 simulations, the differences in the permafrost degradation may be attributed to the spatial variations in surface air temperature, rainfall, and snowfall, which lead to the differences in the timing of permafrost degradation up to 40 years. Although atmospheric temperatures in CE1 and RCP4.5 simulations are similar, net primary production is higher in CE1 due to CO2 fertilization. Our investigation of permafrost extent under large‐scale SAI application scenarios suggests that circum‐Arctic permafrost area and extent is rather sensitive to temperature changes created under such SAI application. Our results highlight the importance of investigating the regional effects of climate engineering, particularly in high‐latitude ecosystems.
Dynamical Coupling Between Hurricane Matthew and the Middle to Upper Atmosphere via Gravity Waves
Authors: Xu Shuang , Yue Jia , Xue Xianghui , Vadas Sharon L. , Miller Steven D. , Azeem Irfan , Straka William , Hoffmann Lars , Zhang Simin
Published: April 2019

During 30 September to 9 October 2016, Hurricane Matthew traversed the Caribbean Sea to the east coast of the United States. During its period of greatest intensity, in the central Caribbean, Matthew excited a large number of concentric gravity waves (GWs or CGWs). In this paper, we report on hurricane‐generated CGWs observed in both the stratosphere and mesosphere from spaceborne satellites and in the ionosphere by ground Global Positioning System receivers. We found CGWs with horizontal wavelengths of ~200–300 km in the stratosphere (height of ~30–40 km) and in the airglow layer of the mesopause (height of ~85–90 km), and we found concentric traveling ionospheric disturbances (TIDs or CTIDs) with horizontal wavelengths of ~250–350 km in the ionosphere (height of ~100–400 km). The observed TIDs lasted for more than several hours on 1, 2, and 7 October 2016. We also briefly discuss the vertical and horizontal propagation of the Hurricane Matthew‐induced GWs and TIDs. This study shows that Hurricane Matthew induced significant dynamical coupling between the troposphere and the entire middle and upper atmosphere via GWs. It is the first comprehensive satellite analysis of gravity wave propagation generated by hurricane event from the troposphere through the stratosphere and mesosphere into the ionosphere.
Statistical Postprocessing of Water Level Forecasts Using Bayesian Model Averaging With Doubly Truncated Normal Components
Authors: Baran Sándor , Hemri Stephan , El Ayari Mehrez
Published: April 2019

Accurate and reliable probabilistic forecasts of hydrological quantities like runoff or water level are beneficial to various areas of society. Probabilistic state‐of‐the‐art hydrological ensemble prediction models are usually driven with meteorological ensemble forecasts. Hence, biases and dispersion errors of the meteorological forecasts cascade down to the hydrological predictions and add to the errors of the hydrological models. The systematic parts of these errors can be reduced by applying statistical postprocessing. For a sound estimation of predictive uncertainty and an optimal correction of systematic errors, statistical postprocessing methods should be tailored to the particular forecast variable at hand. Former studies have shown that it can make sense to treat hydrological quantities as bounded variables. In this paper, a doubly truncated Bayesian model averaging (BMA) method, which allows for flexible postprocessing of possibly multimodel ensemble forecasts of water level, is introduced. A case study based on water levels for a gauge of river Rhine reveals a good predictive skill of doubly truncated BMA compared both to the raw ensemble and the reference ensemble model output statistics approach. Using rolling training periods, BMA considerably outerperforms ensemble model output statistics. However, this gap shrinks drastically when using analog‐based training periods.
The Magnetic Signatures of the M2, N2, and O1 Oceanic Tides Observed in Swarm and CHAMP Satellite Magnetic Data
Authors: Grayver Alexander V. , Olsen Nils
Published: April 2019

This paper reports on new results in the determination of magnetic signals produced by oceanic tides as estimated from satellite magnetic measurements. We find that combining data from the past CHAMP (2000–2010) and the present Swarm (since 2013) satellite missions significantly improves the quality of the extracted tidal signals, in particular if along‐track and cross‐track magnetic “gradient” data are utilized. This allows us to determine the magnetic signature not only of the M2 tide but also of the much weaker N2 and O1 tidal constituents. To minimize disturbances from magnetospheric and ionospheric currents, we only use data from the nightside region during geomagnetic quiet conditions and remove core, crustal, and magnetospheric field contributions as given by the CHAOS geomagnetic field model. Despite their small magnitudes, all determined tidal constituents show sensitivity to the electrical conductivity profile of the underlying mantle, enabling imaging the upper mantle below the oceans.
Assessment of pain symptoms and quality of life using the International Spinal Cord Injury Data Sets in persons with chronic spinal cord injury
Authors: Gibbs Katie , Beaufort Andrew , Stein Adam , Leung Tung Ming , Sison Cristina , Bloom Ona
Published: April 2019

Introduction

Traumatic spinal cord injury (SCI) triggers complex changes that can negatively impact health and quality of life. The International SCI Data Sets were developed to enable more comparable data collection on the complex sequelae of SCI across studies. This should facilitate progress in mechanistic understanding and improving treatments of SCI.

Study design

Prospective observational pilot study.

Objectives

To collect data on pain symptoms and quality of life (QoL) in adults living with chronic SCI.

Setting

Academic medical center, New York, USA.

Methods

The International SCI Basic Pain and Qol Data Sets were used to collect data from participants with chronic SCI (N = 31) at 2 study visits held 6 months apart. The QoL Data Set was also used to collect data from able-bodied persons of similar age and gender distribution (N = 28).

Results

Most participants with SCI had multiple types and locations of pain problems at both study visits, despite reported being treated for pain. At both visits, the worst pain problem type was nociceptive, followed by neuropathic, which was typically rated of higher intensity. QoL scores were significantly lower across all domains of the data set in persons with SCI than able-bodied persons. Persons with pain tended to have lower QoL scores, although this trend was not significant.

Conclusions

This study demonstrates the presence, complexity and stability of pain symptoms refractory to treatment and lower quality of life ratings in persons with chronic SCI.

Sponsorship

Grants from the Craig H. Neilsen Foundation, New York Empire Clinical Research Program, New York State Spinal Cord Injury Research Board.
miR-4521-FAM129A axial regulation on ccRCC progression through TIMP-1/MMP2/MMP9 and MDM2/p53/Bcl2/Bax pathways
Authors: Feng Xue , Yan Naimeng , Sun Weibin , Zheng Shanliang , Jiang Sixiong , Wang Jinxia , Guo Chunmei , Hao Lihong , Tian Yuxiang , Liu Shuqing , Sun Ming-Zhong
Published: April 2019

Clear cell renal cell carcinoma (ccRCC) is the most aggressive RCC subtype with high metastasis, chemotherapy and radiotherapy resistance, and poor prognosis. This study attempted to establish the deregulations of miR-4521 and FAM129A together with their correlation to and mechanism of regulation of ccRCC development and progression. FAM129A acted as tumor promotor and miR-4521 acted as a suppressor in ccRCC. As measured in surgical tumorous tissues from ccRCC patients, FAM129A overexpression and miR-4521 deficiency together contributed to ccRCC progression by promoting advances in patients’ TNM stage and Fuhrman grade. Both the FAM129A knockdown and miR-4521 overexpression could reduce the in vitro migration and invasion abilities of renal cancer cells 786-O and ACHN, through the TIMP-1/MMP2/MMP9 pathway and could decrease their proliferation by promoting their apoptosis through the MDM2/p53/Bcl2/Bax pathway. By directly targeting the 3′-UTR domain ofFAM129A, miR-4521 was negatively correlated withFAM129A/FAM129A levels in ccRCC progression and renal cancer cell malignancies. This work establishes the miR-4521-FAM129A axial regulation mechanism in ccRCC. Micro-4521 deficiency leads toFAM129A/FAM129A upregulation, which synergistically enhances the migration and invasion of renal cancer cells due to the induced decrease of TIMP-1 and increases of MMP2 and MMP9, and increases their growth through escaping apoptosis by suppressing p53 by way of upregulation of induced MDM2. The current work provides new clues to assist fundamental research into the diagnosis and treatment of ccRCC.
Centromere mechanical maturation during mammalian cell mitosis
Authors: Harasymiw Lauren A. , Tank Damien , McClellan Mark , Panigrahy Neha , Gardner Melissa K.
Published: April 2019

During mitosis, tension develops across the centromere as a result of spindle-based forces. Metaphase tension may be critical in preventing mitotic chromosome segregation errors, however, the nature of force transmission at the centromere and the role of centromere mechanics in controlling metaphase tension remains unknown. We combined quantitative, biophysical microscopy with computational analysis to elucidate the mechanics of the centromere in unperturbed, mitotic human cells. We discovered that the mechanical stiffness of the human centromere matures during mitotic progression, which leads to amplified centromere tension specifically at metaphase. Centromere mechanical maturation is disrupted across multiple aneuploid cell lines, leading to a weak metaphase tension signal. Further, increasing deficiencies in centromere mechanical maturation are correlated with rising frequencies of lagging, merotelic chromosomes in anaphase, leading to segregation defects at telophase. Thus, we reveal a centromere maturation process that may be critical to the fidelity of chromosome segregation during mitosis.
QUIRKY regulates root epidermal cell patterning through stabilizing SCRAMBLED to control CAPRICE movement in Arabidopsis
Authors: Song Jae Hyo , Kwak Su-Hwan , Nam Kyoung Hee , Schiefelbein John , Lee Myeong Min
Published: April 2019

SCM, a leucine-rich repeat receptor-like kinase, is required for root epidermal cells to appropriately interpret their location and generate the proper cell-type pattern during Arabidopsis root development. Here, via a screen for scm-like mutants we describe a new allele of the QKY gene. We find that QKY is required for the appropriate spatial expression of several epidermal cell fate regulators in a similar manner as SCM in roots, and that QKY and SCM are necessary for the efficient movement of CPC between epidermal cells. We also show that turnover of SCM is mediated by a vacuolar degradation pathway triggered by ubiquitination, and that QKY prevents this SCM ubiquitination through their physical interaction. These results suggest that QKY stabilizes SCM through interaction, and this complex facilitates CPC movement between the epidermal cells to help establish the cell-type pattern in the Arabidopsis root epidermis.
Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling
Authors: Wong Hoi Leong Xavier , Qin Hong-yan , Tsang Siu Wai , Zuo Xiao , Che Sijia , Chow Chi Fung Willis , Li Xi , Xiao Hai-tao , Zhao Ling , Huang Tao , Lin Cheng Yuan , Kwan Hiu Yee , Yang Tao , Longo Frank M. , Lyu Aiping , Bian Zhao-xiang
Published: April 2019

Early childhood is a critical period for development, and early life stress may increase the risk of gastrointestinal diseases including irritable bowel syndrome (IBS). In rodents, neonatal maternal separation (NMS) induces bowel dysfunctions that resemble IBS. However, the underlying mechanisms remain unclear. Here we show that NMS induces expansion of intestinal stem cells (ISCs) and their differentiation toward secretory lineages including enterochromaffin (EC) and Paneth cells, leading to EC hyperplasia, increased serotonin production, and visceral hyperalgesia. This is reversed by inhibition of nerve growth factor (NGF)-mediated tropomyosin receptor kinase A (TrkA) signalling, and treatment with NGF recapitulates the intestinal phenotype of NMS mice in vivo and in mouse intestinal organoids in vitro. Mechanistically, NGF transactivates Wnt/β-catenin signalling. NGF and serotonin are positively correlated in the sera of diarrhea-predominant IBS patients. Together, our findings provide mechanistic insights into early life stress-induced intestinal changes that may translate into treatments for gastrointestinal diseases.
The pro-angiogenic role of hypoxia inducible factor stabilizer FG-4592 and its application in an in vivo tissue engineering chamber model
Authors: Zhou Muran , Hou Jinfei , Li Yuan , Mou Shan , Wang Zhenxing , Horch Raymund E. , Sun Jiaming , Yuan Quan
Published: April 2019

Tissue engineering is a promising technology used as an alternative to organ/tissue transplantation which is often limited by donor shortage. The construction of large-sized engineered tissue requires a fast and sufficient vascularization process. Previous studies have shown that hypoxia-inducible factor (HIF) -1α may promote the vascularization process implying that stabilized HIF-1α can be applied in the engineering of large-sized tissue. However, the toxicity and off-target effect of previously reported HIF-1α stabilizers limit their clinical application. FG-4592, a small molecule specific HIF stabilizer, was previously investigated as an anti-anemia drug in a phase-III clinical trial. Here we found that FG-4592 promoted tube formation in an in vitro model of angiogenesis by stabilizing HIF-1α and activating vascular endothelial growth factor (VEGF). When FG-4592 immobilized fibrin gel scaffold was implanted into a subcutaneous tissue engineering chamber, the vascularization process was significantly enhanced through the similar mechanisms which was verified in vitro. We conclude that FG-4592 may serve as a pro-angiogenic molecule for the construction of large-sized engineered tissue where intensive angiogenesis is required.
Acute Tubular Injury is Associated With Severe Traumatic Brain Injury: in Vitro Study on Human Tubular Epithelial Cells
Authors: Civiletti Federica , Assenzio Barbara , Mazzeo Anna Teresa , Medica Davide , Giaretta Fulvia , Deambrosis Ilaria , Fanelli Vito , Ranieri Vito Marco , Cantaluppi Vincenzo , Mascia Luciana
Published: April 2019

Acute kidney injury following traumatic brain injury is associated with poor outcome. We investigatedin vitrothe effects of plasma of brain injured patients with acute tubular kidney injury on kidney tubular epithelial cell function. we performed a prospective observational clinical study in ICU in a trauma centre of the University hospital in Italy including twenty-three ICU patients with traumatic brain injury consecutively enrolled. Demographic data were recorded on admission: age 39 ± 19, Glasgow Coma Score 5 (3–8). Neutrophil Gelatinase-Associated Lipocalin and inflammatory mediators were measured in plasma on admission and after 24, 48 and 72 hours; urine were collected for immunoelectrophoresis having healthy volunteers as controls. Human renal proximal tubular epithelial cells were stimulated with patients or controls plasma. Adhesion of freshly isolated human neutrophils and trans-epithelial electrical resistance were assessed; cell viability (XTT assay), apoptosis (TUNEL staining), Neutrophil Gelatinase-Associated Lipocalin and Megalin expression (quantitative real-time PCR) were measured. All patients with normal serum creatinine showed increased plasmatic Neutrophil Gelatinase-Associated Lipocalin and increased urinary Retinol Binding Protein and α1-microglobulin. Neutrophil Gelatinase-Associated Lipocalin was significantly correlated with both inflammatory mediators and markers of tubular damage. Patient’ plasma incubated with tubular cells significantly increased adhesion of neutrophils, reduced trans-epithelial electrical resistance, exerted a cytotoxic effect and triggered apoptosis and down-regulated the endocytic receptor Megalin compared to control. Plasma of brain injured patients with increased markers of subclinical acute kidney induced a pro-inflammatory phenotype, cellular dysfunction and apoptotic death in tubular epithelial cells.
Publisher Correction: Increase in Interfacial Adhesion and Electrochemical Charge Storage Capacity of Polypyrrole on Au Electrodes Using Polyethyleneimine
Authors: Kim Kyung-Geun , Kim Sung Yeol
Published: April 2019

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