bluuebunny/crossref_metadata_2025 huggingface dataset:
Sex-dependent metabolism of ketamine and (2R,6R)-hydroxynorketamine in mice and humans
Authors: Highland Jaclyn N , Farmer Cristan A , Zanos Panos , Lovett Jacqueline , Zarate Carlos A , Moaddel Ruin , Gould Todd D
Published: December 2021

Background:

Ketamine is rapidly metabolized to norketamine and hydroxynorketamine (HNK) metabolites. In female mice, when compared to males, higher levels of ( 2R,6R;2S,6S)-HNK have been observed following ketamine treatment, and higher levels of ( 2R,6R)-HNK following the direct administration of ( 2R,6R)-HNK.

Aim:

The objective of this study was to evaluate the impact of sex in humans and mice, and gonadal hormones in mice on the metabolism of ketamine to form norketamine and HNKs and in the metabolism/elimination of ( 2R,6R)-HNK.

Methods:

In CD-1 mice, we utilized gonadectomy to evaluate the role of circulating gonadal hormones in mediating sex-dependent differences in ketamine and ( 2R,6R)-HNK metabolism. In humans (34 with treatment-resistant depression and 23 healthy controls) receiving an antidepressant dose of ketamine (0.5 mg/kg i.v. infusion over 40 min), we evaluated plasma levels of ketamine, norketamine, and HNKs.

Results:

In humans, plasma levels of ketamine and norketamine were higher in males than females, while ( 2R,6R;2S,6S)-HNK levels were not different. Following ketamine administration to mice (10 mg/kg i.p.), Cmax and total plasma concentrations of ketamine and norketamine were higher, and those of ( 2R,6R;2S,6S)-HNK were lower, in intact males compared to females. Direct ( 2R,6R)-HNK administration (10 mg/kg i.p.) resulted in higher levels of ( 2R,6R)-HNK in female mice. Ovariectomy did not alter ketamine metabolism in female mice, whereas orchidectomy recapitulated female pharmacokinetic differences in male mice, which was reversed with testosterone replacement.

Conclusion:

Sex is an important biological variable that influences the metabolism of ketamine and the HNKs, which may contribute to sex differences in therapeutic antidepressant efficacy or side effects.
The utility of dual-energy computed tomography angiography for the evaluation of brain aneurysms after endovascular coiling: a prospective study
Authors: Dolati Parviz , Ogilvy Christopher S
Published: December 2021

Background

Non-invasive alternatives to digital subtraction angiography (DSA) for follow-up of patients with coiled aneurysms are sought.

Purpose

To compare a novel method of dual-energy computed tomography angiography (DE-CTA) for postoperative assessment of coiled brain aneurysms to detect aneurysm recanalization and patency of adjacent blood vessels, with DSA.

Material and Methods

Patients who underwent endovascular cerebral aneurysm coiling were prospectively evaluated postoperatively by both DE-CTA and conventional DSA. CTA was performed using a novel dual-energy method with single-source and fast kilovoltage switching. DSA was performed using biplanar cerebral angiography. An experienced neuroradiologist and neurosurgeon, both blinded to the original radiological results, reviewed the images.

Results

A total of 54 patients (16 men, 38 women; mean age=47.6 + 9 years) with 55 coiled aneurysms were enrolled in our study between July 2014 and June 2015: 29 patients had suffered a subarachnoid hemorrhage and 26 patients had an incidentally found cerebral aneurysm. All patients had at least one DSA and DE-CTA performed at most one week apart. DE-CTA showed a 100% sensitivity and specificity in detection of complete aneurysm occlusion and 80% sensitivity and specificity for detection of residual necks and domes. DE-CTA successfully detected all vascular diameter changes as comparable to DSA with minimal interfering artifact.

Conclusion

DE-CTA is a promising non-invasive alternative to conventional catheter-based angiography for identification of aneurysm recurrence and assessment of adjacent arteries after endovascular coiling. It allows for far more rapid image acquisition than DSA, is non-invasive, and is widely available at clinical centers.
Use of ABC/2 method for rapidly estimating the target mismatch on computed tomography perfusion imaging in patients with acute ischemic stroke
Authors: Shen Guang-Chen , Chu Yue , Ma Gao , Xu Xiao-Quan , Lu Shan-Shan , Shi Hai-Bin , Wu Fei-Yun
Published: December 2021

Background

Target mismatch (ischemic core, mismatch volume and mismatch ratio) in patients with acute ischemic stroke (AIS) highly relies on the automated perfusion analysis software.

Purpose

To evaluate the feasibility and accuracy of using the ABC/2 method to rapidly estimate the target mismatch on computed tomography perfusion (CTP) imaging in patients with AIS, using RAPID results as a reference.

Material and Methods

In total, 243 patients with anterior circulation AIS who underwent CTP imaging were retrospectively reviewed. Target mismatch associated perfusion parameters were derived from RAPID results and calculated using the ABC/2 method. Paired t-test was used to assess the difference of volumetric parameters between the two methods. The ability of using the ABC/2 method to predict the important cutoff volumetric metrics was also evaluated.

Result

There was no significant difference in the volumes of ischemic core ( P = 0.068), ischemic area ( P = 0.209), and mismatch volume ( P = 0.518) between ABC/2 and RAPID. Using RAPID results as reference, the ABC/2 method showed high accuracy for predicting perfusion parameters (70 mL and 90 mL: sensitivity=98.5% and 98.5%, specificity=100% and 100%, positive predictive value [PPV]=100% and 100%, negative predictive value [NPV]=93.8% and 92.9%; 10 mL and 15mL: sensitivity=99.6% and 99.5%, specificity=55.6% and 50.0%, PPV=96.6% and 94.8%, NPV=90.9% and 92.3%; 1.2 and 1.8: sensitivity=99.6% and 94.8%, specificity=75.0% and 96.9%, PPV=98.7% and 99.5%, NPV=90.0% and 73.8%).

Conclusion

The ABC/2 method may be a feasible alternative to RAPID for estimation of target mismatch parameters on CTP in patients with AIS.
Debtor spaces: Austerity, space, and dispossession in Michigan’s emergency management system
Authors: Heil Melissa
Published: December 2021

In recent years, debt has become a major focus of geographic research as debt relations have become increasingly central to today’s financialized capitalist economy. This paper bridges two aspects of the debt literature: (1) the emergent literature on debt spatiality, which argues that space plays an active role in the creation and maintenance of debt relations, and (2) the broader literature examining processes of debt-driven dispossession (e.g., foreclosure, eviction, austerity, etc.). Recent literature in geography, led by Harker’s work on debt spaces, has argued that debt should not only be understood as a temporal relation (a promise of future labor) but a spatial relation as well. This literature has examined the active role of space in creating debt relations but has been less attentive to the ways in which debt is a key mechanism of dispossessive economies. Analyzing Michigan’s emergency management laws, a system of forced, localized austerity, I chronicle how the social production of space is central to dispossessive debt projects. I conclude by offering a new concept, debtor spaces, to characterize the socio-spatial formations which enable practices of debt-based dispossession.
Multi-layered electrospinning and electrospraying approach: Effect of polymeric supplements on chondrocyte suspension
Authors: Semitela Ângela , Leal Pereira Andreia , Sousa Cátia , Mendes Alexandrina F. , Marques Paula A.A.P. , Completo António
Published: December 2021

Articular cartilage was expected to be one of the first tissues to be successfully engineered, but replicating the complex fibril architecture and the cellular distribution of the native cartilage has proven difficult. While electrospinning has been widely used to reproduce the depth-dependent fibre architecture in 3D scaffolds, the chondrocyte-controlled distribution remains an unsolved problem. To incorporate cells homogeneously through the depth of scaffolds, a combination of polymer electrospinning and cell seeding is necessary. A multi-layer approach alternating between polymer electrospinning with chondrocyte electrospraying can be a solution. Still, the success of this process is related to the survival rate of the electrosprayed chondrocytes embedded within the electrospun mesh. In this regard, the present study investigated the impact of the multi-layered process and the supplementation of the electrospray chondrocyte suspension with different concentrations of Gelatin and Alginate on the viability of electrosprayed chondrocytes embedded within a Polycaprolactone/Gelatin electrospun mesh and on the mechanical properties of the resulting meshes. The addition of Gelatin in the chondrocyte suspension did not increase significantly ( p > 0.05) the percentage of viable electrosprayed chondrocytes (25%), while 3 wt% Alginate addition led to a significant ( p < 0.05) increase in chondrocyte viability (50%) relative to the case without polymer supplement (15%). Furthermore, the addition of both polymer supplements increased the mechanical properties of the multi-layer construct. These findings imply that this multi-layered approach can be applied to cartilage TE allowing for automated chondrocyte integration during scaffolds creation.
The Hopkins Symptom Checklist (SCL-90-R): A Patient-Reported Outcome Measure in Parkinson’s Disease
Authors: Carrozzino Danilo , Christensen Kaj Sparle , Patierno Chiara , Siri Chiara , Zecchinelli Anna , Pezzoli Gianni , Cosci Fiammetta
Published: December 2021

Objective: This is the first study applying Clinimetric Patient-Reported Outcome Measures (CLIPROM) criteria to evaluate the construct validity, sensitivity, and clinical utility of the SCL-90-R in patients with Parkinson’s disease (PD). Methods: A Rasch analysis was conducted using a sample of 488 PD outpatients. Results: Testing for dimensionality revealed that less than 5% of t-tests were significant, indicating that the SCL-90-R subscales entailed the property of construct validity. As to the total score, a Person Separation Reliability Index of .96 was found. Conclusions: The SCL-90-R total score is a sensitive screening measure that can be used not only to differentiate healthy stress reactions from symptoms of psychological distress but also to detect PD patients with an increased risk for psychiatric complications. As to the subscales, the brief versions that did not include misfitting items should be used to assess the severity of specific symptoms of psychological distress affecting PD patients.
Relationship between care model and disease activity states and health-related quality of life in systemic lupus erythematosus patients
Authors: Perea-Seoane Luciana , Agapito-Vera Estefania , Gamboa-Cardenas Rocío V , Guzmán-Sánchez Geny , Pimentel-Quiroz Victor Román , Reategui-Sokolova Cristina , Medina Mariela , Elera-Fitzcarrald Claudia , Noriega Erika , Rodriguez-Bellido Zoila , Pastor-Asurza Cesar , Perich-Campos Risto , Alarcón Graciela S , Ugarte-Gil Manuel F
Published: December 2021

Objective

To assess whether the care model (comprehensive vs regular) has any impact on the clinical outcomes of systemic lupus erythematosus patients.

Methods

Between August 2019 and January 2020, we evaluated SLE patients being cared for at two Peruvian hospitals to define the impact of care model on disease activity state and health-related quality of life (HRQoL). Disease activity was ascertained with the SLEDAI-2K and the Physician Global Assessment (PGA) which allows to define Lupus Low Disease Activity State (LLDAS) and Remission. HRQoL was measured with the LupusQoL. The association between care model and disease activity (Remission and LLDAS) state was examined using a binary logistic regression model. The association with HRQoL was examined with a linear regression model. All multivariable analyses were adjusted for possible confounders.

Results

266 SLE patients were included, 227 from the comprehensive care model and 39 from the regular care model. The regular care model was associated with a lower probability of achieving remission (OR 0.381; CI: 95% 0.163–0.887) and LLDAS (OR 0.363; CI: 95% 0.157–0.835). Regular care was associated with a better HRQoL in two domains (pain and emotional health). We found no association between the care model and the other HRQoL domains.

Conclusion

A comprehensive care model was associated with the probability of achieving remission and LLDAS but had no apparent impact on the patients’ HRQoL.
Supporting Vulnerable Populations During the Pandemic: Stakeholders’ Experiences and Perceptions of Social Prescribing in Scotland During Covid-19
Authors: Fixsen Dr Alison , Barrett Dr Simon , Shimonovich Michal
Published: December 2021

Social prescribing schemes refer people toward personalized health/wellbeing interventions in local communities. Since schemes hold different representations of social prescribing, responses to the pandemic crisis will vary. Intersectionality states that social divisions build on one another, sustaining unequal health outcomes. We conducted and inductively analysed interviews with twenty-three professional and volunteer stakeholders across three social prescribing schemes in urban and rural Scotland at the start and end of year one of the pandemic. Concerns included identifying and digitally supporting disadvantaged and vulnerable individuals and reduced capacity statutory and third-sector services, obliging link workers to assume new practical and psychological responsibilities. Social prescribing services in Scotland, we argue, represent a collage of practices superimposed on a struggling healthcare system. Those in need of such services are unlikely to break through disadvantage whilst situated within a social texture wherein inequalities of education, health and environmental arrangements broadly intersect with one another.
Myopericytoma of the Parotid and Molecular Profiling: Report of a Rare Case and Review of the Literature
Authors: Roig Nicholas J. , Wu Michelle , Hernandez Osvaldo , Liu Cheng Z. , Brandler Tamar C.
Published: December 2021

Myopericytomas are uncommon tumors defined by their round to spindle shaped cells often arranged in a concentric pattern of perivascular growth. They are typically well-circumscribed, nodular, slow-growing lesions that occur in the soft tissue of the extremities. Here, we present a 30-year-old female with a 2.4 cm myopericytoma occurring in the deep lobe of the parotid gland. The diagnosis was made with detailed histopathologic and immunohistochemical findings and positive identification of the specific mutation for PDGFRβ p.Asp666Lys by next generation sequencing (NGS). This is the first case report of a parotid myopericytoma with a genetic testing that shows a particular mutation that has been linked to myopericytomatosis.
Choice Deprivation, Choice Overload, and Satisfaction with Choices Across Six Nations
Authors: Reutskaja Elena , Cheek Nathan N. , Iyengar Sheena , Schwartz Barry
Published: December 2021

Whether consumers have too little, too much, or the ideal amount of choice can have profound consequences. The present research explores patterns of choice deprivation (having less choice than desired) and choice overload (having more choice than desired) across six choice domains in six countries that together provide home to about half the human population (Brazil, China, India, Japan, Russia, and the United States; combined N = 7,436). In most domains in most countries, choice deprivation was the norm—only in the United States was choice overload commonly reported. Deprivation was also more strongly related to decreased satisfaction with choices than was overload, suggesting that choice deprivation can be both more common and more consequential than overload. The present research has implications for “inverted U-shape” theories of consumer choice experiences and underlines the need for more diverse samples, including cross-cultural samples, in research on choice deprivation and overload.
“Listening” to Science: Science Podcasters’ View and Practice in Strategic Science Communication
Authors: Yuan Shupei , Kanthawala Shaheen , Ott-Fulmore Tanya
Published: December 2021

We have witnessed an increasing amount of science podcasts, and it has emerged as an important venue for science communication. From a strategic science communication perspective, this study investigated how science podcasters view science communication–related goals and objectives, as well as the tactics they use in producing science communication content based on the theory of planned behavior. A survey ( N = 147) with science podcasters showed that they see excitement and interest in science as their most prioritized objective and present the value of science over time. In addition, our results showed that podcasters frequently use communication tactics, but it may not have resulted from planned strategic communication action. The findings of this study provide initial insight into podcasters’ views and practice as part of the science communication effort.
An adaptive sliding mode fault-tolerant control for semi-active suspensions with magnetorheological dampers based on T-S fuzzy vehicle models
Authors: Yang Haohan , Liu Qingwei , Zhang Yongchao , Yu Fan
Published: December 2021

This paper investigates an improved adaptive sliding mode fault-tolerant control strategy for a magnetorheological semi-active suspension system with parametric uncertainties and actuator faults. Using the experimental data collected by a quarter-vehicle test rig, an adaptive-network-based fuzzy inference system is employed to establish a learning-based magnetorheological damper model firstly. The Takagi-Sugeno fuzzy approach is introduced to deal with the uncertainties of sprung mass and pitch rotary inertia and then the corresponding Takagi-Sugeno faulty semi-active suspension system is constructed. An adaptive sliding mode fault-tolerant controller is proposed, in which the magnetorheological damper fault gain is observed by the designed estimation law, and the asymptotical stability of the system is further analyzed. Finally, numerical simulation tests are conducted to demonstrate the effectiveness of the designed control scheme.
Situated Testimony: Forensic Architecture’s Memory Objects
Authors: Kinstler Linda
Published: December 2021

“Forensic Architecture” describes both the research agency, founded in 2011, as well as its investigative method and aesthetic practice. As an emerging discipline, forensic architecture exploits the relation between space, material, and memory. My aim in this article is to consider how the agency’s “memory objects”—aestheticized virtual renderings of their investigations—operate as testimonial objects, evidentiary archives, and simulated sites of conscience. I attend to one “memory object” in particular, a film titled “Drone Strike Investigation Case no. 2: Mir Ali, North Waziristan, 4 October 2010; The Architecture of Memory,” an investigation which the U.N. Special Rapporteur on Counter Terrorism and Human Rights commissioned Forensic Architecture to undertake. This article suggests that this virtual “memory object” troubles the status of both the human witness and the physical landscape to which it refers.
Långbro Hospital, Sweden—From Psychiatric Institution to Digital Museum: A Critical Discourse Analysis
Authors: Punzi Elisabeth
Published: December 2021

Sites of oppression might be remembered in ways that contribute to dialogues about human rights and justice, exemplified by Sites of Conscience. Oppression was commonplace in former psychiatric institutions, yet such institutions are often subject to strategic forgetting and transformed into business parks, hotels, or residential areas. This article concerns Långbro Hospital, a digital museum presenting the former psychiatric institution Långbro, Sweden, now transformed into a residential area. I discuss how the former institution becomes a digital nonplace in which patients tend to be objectified or excluded, and the park and the buildings in which oppression occurred are reduced to representing beauty and functionality. I relate the analysis to digital Sites of Conscience such as British Museum of Colonialism and Pennhurst Memorial and Preservation Alliance and, thereby, show that thoughtful digitization might recognize prior as well as current injustice and oppression and contribute to change.
Memory, Imagination, and Resistance in Canada’s Prison for Women
Authors: Guenther Lisa
Published: December 2021

A group of women who were incarcerated at Canada’s first federal Prison for Women (P4W) have been fighting to create a memorial garden since the prison closed in 2000. In 2017, the prison was sold to a private developer who plans to convert the historic building and grounds into condos, retail, and office space. What does it mean to remember the dead, and to fight for the living, at a time when neoliberal common sense demands the efficient conversion of a place of suffering and death into a “heritage building” on “prime real estate”? How might a collective practice of radical imagination help to resist the commodification of memory into a tourist attraction or an aesthetic improvement of private property? And what is the relation between memory, healing, and accountability in a place where state violence, gender domination, and settler colonialism intersect?
Memories of State Terrorism in Chile: Dark Ruins at Villa Grimaldi
Authors: Aguilera Carolina
Published: December 2021

In this short essay, I explore the recent reassessment of ruined sites haunted by the echoes of State terrorism across the Southern Cone of Latin America, asking what is at stake in the conservation of former detention centers and focusing on Villa Grimaldi in Chile. The site was initially transformed into a green park but has subsequently become a museum in which remains of the original buildings and artifacts from the repressive past are publicly accessible. I draw on perspectives that claim that even ruins that portray past acts of inhumanity do not necessarily need to evoke melancholic or traumatic retrospection; rather, they are sites of alternative pasts and futures. The transition from the original green park design to a more prominent use of the ruins speaks of an invitation to reassess the past, addressing marginal aspects of emblematic memories, including the political conflict that underpinned the repression.
The frequency and characteristics of multiple sclerosis misdiagnosis in Latin America: A referral center study in Buenos Aires, Argentina
Authors: Gaitán María I , Sanchez Melanie , Farez Mauricio F , Fiol Marcela P , Ysrraelit Maria C , Solomon Andrew J , Correale Jorge
Published: December 2021

Objective:

Most contemporary data concerning the frequency and causes of multiple sclerosis (MS) misdiagnosis are from North America and Europe with different healthcare system structure and resources than countries in Latin America. We sought to determine the frequency, and potential contributors to MS misdiagnosis in patients evaluated at an MS referral center in Argentina.

Methods:

The study was a retrospective medical record review. We included patients evaluated at the MS Clinic at Fleni between April 2013 and March 2021. Diagnoses prior to consultation, final diagnoses after consultation, demographic, clinical and paraclinical data, and treatment were extracted and classified.

Results:

Seven hundred thirty-six patients were identified. Five hundred seventy-two presented with an established diagnosis of MS and after evaluation, misdiagnosis was identified in 89 (16%). Women were at 83% greater risk of misdiagnosis ( p = 0.034). The most frequent alternative diagnoses were cerebrovascular disease, radiological isolated syndrome (RIS), and headache. Seventy-four (83%) of misdiagnosed patients presented with a syndrome atypical for demyelination, 62 (70%) had an atypical brain magnetic resonance imaging (MRI), and 54 (61%) were prescribed disease-modifying therapy.

Conclusion:

Sixteen percent of patients with established MS were subsequently found to have been misdiagnosed. Women were at higher risk for misdiagnosis. Expert application of the McDonald criteria may prevent misdiagnosis and its associated morbidity and healthcare system cost.
Discursive representation of the Article 370 abrogation: A comparative CDA of the headlines of two major Indian online news publications
Authors: Nadaf Arif Hussain
Published: December 2021

The Indian government on 5 August, 2019, unilaterally removed Article 370 of its constitution that provided autonomous status to the disputed region of Jammu and Kashmir. In order to pre-empt any backlash, the authorities put the entire region under strict lockdown and imposed a complete communication blackout including suspension of internet, mobile, and landline phone services. The Indian media vociferously covered the issue of higher “national interest” with no counter-narrative from local news media in the region. Using Van Djik’s socio-cognitive model, the study conducted comparative critical discourse analysis of the headlines from two major Indian online news publications; the English daily The Times of India and the Hindi daily Dainik Jagran to identify the discursive strategies adopted by these newspapers after the revocation of the Article 370. The study aimed to understand how Indian newspapers were shaping the discourse when the Indian government imposed communication restrictions and lockdown in the region. Through CDA, the study located the discursive strategies in the headlines and the ideological standpoints they reflected while covering the Article 370 controversy. The CDA found that the headline discourse in both the news publications was characterized by aggressive nationalistic assertion reinforcing domestic legitimacy for the government’s decision. The analysis further showed substantial evidence for the cultural distances between the English and Hindi language news discourse. Unlike English headlines, the Hindi headlines contained explicit linguistic subjectivities and were overtly hyperbolic in recognizing and blending itself with the nationalist assertion and socio-political expression around the abrogation of Article 370.
Reading the represented city and society: signs, theory, and the dynamic interpretativeness of Peircean semiotics
Authors: Goharipour Hamed , Gibson Huston
Published: December 2021

In the era of visual media, cities, and society are represented, experienced, and interpreted through images. The need for interdisciplinary visual approaches, therefore, is indisputable. By focusing on cinema, this paper aims to develop a conceptual, methodological framework through which theory helps a broad range of researchers in social sciences, humanities, and arts interpret the represented phenomenon. Based on Peirce’s model of signs, the framework provides the basis for a dynamic interpretation of the city and society. This paper shows that Peircean cinesemiotics takes advantage of theory in three ways: First, as the basis that provides scholars with clues necessary for identifying eligible “image-signs”; second, as the guiding framework that helps them reach a final interpretation; third, as ideas are being criticized from visual perspectives. As an example of its application, using Jane Jacobs’ “The Death and Life of Great American Cities,” the final part of the paper applies Peircean cinesemiotics to an image-sign from Death Wish (2018) and interprets it as the representation of safety/crime in a neighborhood.
Nationalism is dead, long live nationalism! In pursuit of pluralistic nationalism: A critical overview
Authors: Dikici Erdem
Published: December 2021

Rather than vilifying or rejecting it, an increasing number of scholars from two seemingly anti-nationalist cohorts, namely liberal political theory and multiculturalism, have come to argue that nationalism is not intrinsically illiberal or undesirable, but some forms of it (e.g. liberal, multicultural, pluralistic) can be a positive force to meet the demands for nation-building, national identity and national culture, on the one hand, and demands for recognition, respect and accommodation of diversity, on the other. This paper critically examines recent scholarly literature on liberal nationalism and multicultural nationalism. It argues that both projects have developed necessary responses to (1) growing diversity and (2) ethnonational and populist-majoritarian forms of nationalism and hence, are welcome. However, two substantial shortcomings need to be addressed. The first is the nation-building–education nexus and the limits of multicultural education (e.g. the teaching of history), and the second is the nationalism–transnationalism nexus or the normative desirability of dual nationalities. The paper concludes that a morally acceptable form of nationalism (e.g. pluralistic, inclusive or moderate) operating within multi-national and multicultural liberal democracies is theoretically possible, yet its viability is related to the extent to which it addresses the two issues raised, amongst others.
Exploratory Study of Hybrid Telepractice and In-Person Treatment of Compensatory Articulation Errors in Cleft Palate
Authors: Kotlarek Katelyn J. , Haenssler Abigail E. , Perry Jamie L.
Published: December 2021

A participant with cleft palate and compensatory articulation errors underwent 75 weeks of treatment using a hybrid telepractice and in-person treatment model. This model improved articulation skills during the study period and offers a starting point for continued exploration of telepractice for the treatment of compensatory articulation errors in cleft palate.
Impact of Frailty and Age on Clinical Outcomes in Patients Who Underwent Endovascular Therapy
Authors: Nishikawa Ken , Ebisawa Soichiro , Miura Takashi , Kato Tamon , Yusuke Kanzaki , Abe Naoyuki , Yokota Daisuke , Yanagisawa Takashi , Senda Keisuke , Wakabayashi Tadamasa , Oyama Yushi , Karube Kenichi , Itagaki Tadashi , Yui Hisanori , Maruyama Shusaku , Nagae Ayumu , Sakai Takahiro , Okina Yoshiteru , Nakazawa Shun , Tsukada Shunichi , Saigusa Tatsuya , Okada Ayako , Motoki Hirohiko , Kagoshima Mitsuru , Kuwahara Koichiro
Published: December 2021

Purpose:

Information on the relationship between frailty and the outcome of endovascular therapy (EVT) in older patients with lower extremity peripheral artery disease (PAD) is scarce. This study aimed to reveal the impact of frailty on the prognosis of older population who underwent EVT.

Materials and Methods:

From August 2015 to August 2016, 335 consecutive patients who underwent EVT were enrolled in the I-PAD registry from 7 institutes in Nagano prefecture. Among them, we categorized 323 patients into 4 groups according to age and the presence or absence of frailty as follows: older patients with frailty (age ≥ 75, Clinical Frailty Scale [CFS] ≥ 5), older patients without frailty (age ≥ 75, CFS ≤ 4), young patients with frailty (age < 75, CFS ≥ 5), and young patients without frailty (age < 75, CFS ≤ 4); we analyzed them accordingly. The primary endpoints were major adverse cardiovascular and limb events (MACLE), defined as a composite of cardiovascular death, myocardial infarction, stroke, admission for heart failure, major amputation, and revascularization. The secondary endpoint was cardiovascular death.

Results:

The median follow-up period was 2.7 years. In the older patients with frailty, older patients without frailty, young patients with frailty, and young patients without frailty groups, the freedom rates from MACLE were 34.9%, 55.7%, 35.4%, and 63.0%, respectively (p<0.001) and from all-cause death were 43.5%, 73.4%, 50.7%, and 90.9%, respectively (p<0.001). The freedom rates from MACLE were significantly higher among older patients with frailty than among young patients without frailty (55.7% vs 35.4%, p=0.01). In multivariate analysis, frailty was independently associated with MACLE incidence.

Conclusion:

Frailty as defined by CFS might be a predictor of MACLE incidence in patients with PAD who underwent EVT. By considering treatment indications for patients with PAD by focusing on frailty rather than age, we may examine whether EVT policies are appropriate and manage patient and caregiver expectations for potential improvement in functional outcomes. Further studies are expected to investigate whether changes in frailty after EVT change prognosis.
Aortic Intramural Hematoma due to Intercostal Artery Aneurysms
Authors: Shehab Maysam , Wolf Ammie , Ajaj Mones , Greton Igal , Fajer Simmone
Published: December 2021

Background

Intercostal artery aneurysms (ICA) are rare vascular disease. A rupture of ICA is a possible mechanism of intramural aortic hematoma (IH). We report a case with IH and ICAs without clear etiology. Case presentation: A 64-year-old man was admitted to our emergency room with a sudden onset of acute diffused abdominal and chest pain, radiating to the back. Without previous traumatic insult, a computed tomographic angiography scan (CTA) revealed an IH beginning inferior to the left subclavian artery extending to the level of the celiac trunk. Follow-up CTA demonstrated a stable maximal IH thickness diameter of 11 mm, maximal aortic diameter of 40 mm, a new left hemorrhagic pleural effusion, and a focal contrast enhancement at T9 level. Due to these findings, thoracic endovascular aortic repair (TEVAR) was performed. During follow up, T9 focal enhancement continues to grow and an additional one developed. Selective angiography was performed demonstrating a connection to the costal artery and the aortic lumen, confirming ICA. Successful embolization with micro coils was performed. During follow up, additional 2 ICAs developed and treated with embolization. CTA three months later showed a complete resolution of the IH and obliteration of all treated ICAs. Infectious, inflammatory and connective tissue disease investigations were undertaken without a clear etiology. Conclusions: This is a case of IH and ICAs, in the absence of a clear etiology which were successfully treated by endovascular procedures TEVAR and coil embolization. It is not clear whether the hematoma was the source of the ICA or the other way round. Lack of ICAs in the initial CTA might be due to the pressure exerted by the hematoma or that they were too small to be detected but continued to grow on follow up. Rupture of these micro-aneurysms is a possible mechanism of intramural aortic hematoma.
Facial Stereotyping Drives Judgments of Perceptually Ambiguous Social Groups
Authors: Bin Meshar Maryam , Stolier Ryan M. , Freeman Jonathan B.
Published: December 2021

When seeing a face, people form judgments of perceptually ambiguous social categories (PASCs), for example, gun-owners, gay people, or alcoholics. Previous research has assumed that PASC judgments arise from the statistical learning of facial features in social encounters. We propose, instead, that perceivers associate facial features with traits (e.g., extroverted) and then infer PASC membership via learned stereotype associations with those traits. Across three studies, we show that when any PASC is more stereotypically associated with a trait (e.g., alcoholics = extroverted), perceivers are more likely to infer PASC membership from faces conveying that trait (Study 1). Furthermore, we demonstrate that individual differences in trait–PASC stereotypes predict face-based judgments of PASC membership (Study 2) and have a causal role in these judgments (Study 3). Together, our findings imply that people can form any number of PASC judgments from facial appearance alone by drawing on their learned social–conceptual associations.
Wedeven Associates: Finding New Ways to Develop Novel Solutions to Persistent, Intractable Problems
Authors: Jonsen Richard H
Published: December 2021

Wedeven Associates is a small tribology research and engineering consulting firm located near Philadelphia, Pennsylvania. The company faced a variety of challenges associated with the COVID-19 pandemic as did most small businesses in 2020. As the company became fully operational again, Wedeven Associates was approached by a longtime client to solve a tribological problem the client’s engineers had been trying to address for many years. The catch: Wedeven Associates only had a little over 2 months to do the work while complying with pandemic-related travel and meeting restrictions. This case tells the story of how the Wedeven Associates team met the challenge using virtual tools and a collaborative approach built on first principles. Readers are introduced to “tribology” as an engineering discipline and “first principles” as a problem-solving approach.
Trend in survival after out-of-hospital cardiac arrest and its relationship with bystander cardiopulmonary resuscitation: a six-year prospective observational study in Beijing
Authors: Chen Yuling , Yue Peng , Wu Ying , Li Jia , Lei Yanni , Gao Ding , Liu Jiang , Han Pengda
Published: December 2021

Background

Out-of-hospital cardiac arrest (OHCA), a global health problem with a survival rate ranging from 2 to 22% across different countries, has been a leading cause of premature death for decades. The aim of this study was to evaluate the trends of survival after OHCA over time and its relationship with bystander cardiopulmonary resuscitation (CPR), initial shockable rhythm, return of spontaneous circulation (ROSC), and survived event.

Methods

In this prospective observational study, data of OHCA patients were collected following the “Utstein style” by the Beijing, China, Emergency Medical Service (EMS) from January 2011 (data from February to June in 2011 was not collected) to October 2016. Patients who had a cardiac arrest and for whom an ambulance was dispatched were included in this study. All cases were followed up to determine hospital discharge or death. The trend of OHCA survival was analyzed using the Chi-square test. The relationship among bystander CPR, initial shockable rhythm, ROSC, survived event, and OHCA survival rate was analyzed using multivariate path analyses with maximum standard likelihood estimation.

Results

A total of 25,421 cases were transferred by the Beijing EMS; among them, 5042 (19.8%) were OHCA (median age: 78 years, interquartile range: 63–85, 60.1% male), and 484 (9.6%) received bystander CPR. The survival rate was 0.6%, which did not improve from 2012 to 2015 (P = 0.569). Overall, bystander CPR was indirectly associated with an 8.0% (β = 0.080, 95% confidence interval [CI] = 0.064–0.095, P = 0.002) increase in survival rate. The indirect effect of bystander CPR on survival rate through survived event was 6.6% (β = 0.066, 95% CI = 0.051–0.081, P = 0.002), which accounted for 82.5% (0.066 of 0.080) of the total indirect effect. With every 1 increase in survived event, the possibility of survival rate will directly increase by 53.5% (β = 0.535, 95% CI = 0.512–0.554, P = 0.003).

Conclusions

The survival rate after OHCA was low in Beijing which has not improved between 2012 and 2015. The effect of bystander CPR on survival rate was mainly mediated by survived event.

Trial registration

Chinese Clinical Trial Registry: ChiCTR-TRC-12002149 (2 May, 2012, retrospectively registered). http://www.chictr.org.cn/showproj.aspx?proj=7400
PNC2 (SLC25A36) Deficiency Associated With the Hyperinsulinism/Hyperammonemia Syndrome
Authors: Shahroor Maher A , Lasorsa Francesco M , Porcelli Vito , Dweikat Imad , Di Noia Maria Antonietta , Gur Michal , Agostino Giulia , Shaag Avraham , Rinaldi Teresa , Gasparre Giuseppe , Guerra Flora , Castegna Alessandra , Todisco Simona , Abu-Libdeh Bassam , Elpeleg Orly , Palmieri Luigi
Published: December 2021

Context

The hyperinsulinism/hyperammonemia (HI/HA) syndrome, the second-most common form of congenital hyperinsulinism, has been associated with dominant mutations in GLUD1, coding for the mitochondrial enzyme glutamate dehydrogenase, that increase enzyme activity by reducing its sensitivity to allosteric inhibition by GTP.

Objective

To identify the underlying genetic etiology in 2 siblings who presented with the biochemical features of HI/HA syndrome but did not carry pathogenic variants in GLUD1, and to determine the functional impact of the newly identified mutation.

Methods

The patients were investigated by whole exome sequencing. Yeast complementation studies and biochemical assays on the recombinant mutated protein were performed. The consequences of stable slc25a36 silencing in HeLa cells were also investigated.

Results

A homozygous splice site variant was identified in solute carrier family 25, member 36 (SLC25A36), encoding the pyrimidine nucleotide carrier 2 (PNC2), a mitochondrial nucleotide carrier that transports pyrimidine as well as guanine nucleotides across the inner mitochondrial membrane. The mutation leads to a 26-aa in-frame deletion in the first repeat domain of the protein, which abolishes transport activity. Furthermore, knockdown of slc25a36 expression in HeLa cells caused a marked reduction in the mitochondrial GTP content, which likely leads to a hyperactivation of glutamate dehydrogenase in our patients.

Conclusion

We report for the first time a mutation in PNC2/SLC25A36 leading to HI/HA and provide functional evidence of the molecular mechanism responsible for this phenotype. Our findings underscore the importance of mitochondrial nucleotide metabolism and expand the role of mitochondrial transporters in insulin secretion.
The vascular flora ecological diversity in the mid-field woodlots situated on the agricultural outskirts of Wrocław
Authors: Fudali Ewa , Podlaska Magda , Koszelnik-Leszek Anna
Published: December 2021

The paper presents an analysis of the ecological requirements and sociological-ecological relations of 403 species of vascular plants recorded in 82 mid-field woodlots located among crop fields in the agricultural outskirts of Wrocław. The aim of the research and analyses was to determine what is the species composition of these woodlots and whether they are ecologically more similar to those situated in environment of farmlands or urban wastelands. The authors assumed the latter. It was found that the mid-­ -field woodlots occupied less than 1% of arable land and were located exclusively in close proximity to the city’s administrative borders, and more than half of them were related to the hydrographic network of the area. Their flora, in general assessment, shows a great variety in terms of water requirements and has the features of woodlots described from typically agricultural areas. This applies to the dominance of forest, shrub and meadow species with a constant, usually not exceeding 20%, share of ruderal plants and a small number of weeds in crops. Thus, the assumption that the flora of the studied woodlots will show signs of ruderalization to a large extent has not been confirmed. 72% of species occurred in no more than 10 objects, which shows that the described ecological diversity of the flora studied is based on single or few locations. The most frequent species were nitrophilic and in over 50% they represented a group of shrub communities. The list of the species recorded with estimation of their frequency is provided.
Górski gatunek Chamaenerion palustre (Onagraceae) w Wielkopolsce
Authors: Czarna Aneta
Published: December 2021

Chamaenerion palustre is distributed in Poland mostly in mountains. It was found in the lowland of Wielkopolska at two ruderal localities on rocky substrates: in 2008 in the town of Buk on a railway siding, and in 2019 in the town of Głogów near railway tracks at the train station.
La Donna, Il Servo E Il Cittadino
Authors: Melis Valeria
Published: December 2021

In Po. 1454a 16–28, Aristotele afferma che, per essere ben riusciti, tutti gli ἤθη della tragedia devono essere χρηστά, donne e schiavi compresi. L’aggettivo χρηστός, presente solo in questo luogo della Poetica, comporta importanti problemi esegetici e traduttivi, che hanno dato luogo a molteplici interpretazioni e traduzioni del termine. Posti sotto esame i principali tentativi esegetici di χρηστός in Po. 1454a 16–28 dalla metà del Novecento agli anni Duemila, il presente contributo offre una nuova ipotesi esegetica dell’aggettivo, fondandosi sull’analisi del suo valore semantico in alcuni passi delle commedie di Aristofane e dei discorsi degli oratori attici del IV sec. a.C., sulla concezione della natura della donna e dello schiavo che emerge da Aristot. Pol. I 1253b–1260b 24 e sulla menzione aristotelica del personaggio di Menelao dell’Oreste di Euripide come παράδειγμα πονηρίας ἤθους μὴ ἀναγκαίας (Po. 1454a 28–29).
Un Caso Difficile Nel Testo Della Fisica Di Aristotele (216a29-31) Nel Commentario Di Giovanni Filopono
Authors: Ottobrini Tiziano F.
Published: December 2021

I commenti neoplatonici ad Aristotele, oltre a dare indicazioni interpretative su questioni di contenuto, possono non solo far riflettere ma anche dare importanti indicazioni sul testo aristotelico e sulla sua traditio textus. In questo saggio verrà illustrato un caso particolarmente significativo, contenuto nel commento alla Fisica scritto da Giovanni Filopono (prima metà del VI secolo): in Phys. 216a29-31, infatti, occorre una lectio (συνίστασθαι) diversa dal testo canonico di Aristotele attestato dai manoscritti (μεθίστασθαι). La competenza filologica di Filopono avvalora particolarmente questa lectio che risulta non aver avuto nell’antichità adeguate testimonianze; infatti, i manoscritti medievali continuano una tradizione diversa. Il caso esaminato intende riportare l’attenzione sull’importanza che la produzione ipomnematica tardoantica può offrire nel valutare, almeno in casi particolari, quale testo dello Stagirita circolasse prima che si costituisse una vulgata aristotelica, quella data dai codici medievali.
Nikos Kazantzakis’ Unshot Adaptations of Don Quixote and Decameron
Authors: Mini Panayiota
Published: December 2021

This article examines two of Nikos Kazantzakis’ unshot screenplays of the early 1930s: his adaptations of Cervantes’ Don Quixote and Boccaccio’s Decameron, kept in typed manuscripts at the Nikos Kazantzakis Museum Foundation in Iraklion, Crete. The article analyses Kazantzakis’ Don Quixote and Decameron in the contexts of early talking cinema and his ideas of the image-language relationship. Written at a time when the artistic value of talking cinema was still debated, Kazantzakis’ adaptations demonstrate that he sought to express ideas with images rather than dialogue (Don Quixote) and use sound as a creative element (Decameron) in ways alluding to Eisenstein’s 1928-1929 writings, with which, as evidence suggests, the Greek author was familiar. Thus, Kazantzakis’ Don Quixote and Decameron show how a technological development in film history – the coming of sound – and the Soviet film theory influenced this author’s adaptation techniques, while also enhancing our understanding of his creative career as well as the worldwide resonance of Cervantes’ and Boccaccio’s literary milestones.
Perché I Medici Parlano Ancora Il Greco?
Authors: Petropoulos Ioannis
Published: December 2021

Although the extraordinary progress in medicine since the 19th century has made Hippocrates and Galen irrelevant, Greek and Greek-derived terms continue to be used in the medical sciences today. The marked ability of the Greek language to form compounds facilitated the expansion of its medical lexicon. Greek medicine evolved far longer than its modern counterpart; its enduring cachet has lent it an atemporality. This article traces the main stages in the history of the nearly continuous reception of Greek medical nomenclature across more than two millennia. The process is shown to have been inseparable from the transmission and editing of Greek medical texts and their translation into Latin, Arabic, and eventually into vernacular languages. The article also sheds incidental light on the history of translation and transliteration in Europe and the Arab world.