bluuebunny/crossref_metadata_2025 huggingface dataset:
Imagen, fotografía y productores
Authors: Aguayo Fernando
Published: January 2016

Este artículo es una propuesta de investigación transdisciplinaria para construir una historia social con ayuda de la fotografía. Retoma la experiencia de trabajo efectuada para la puesta en línea de la fototeca digital Fotógrafos y editores franceses en México, la cual implicó una investigación histórica que incorporó el análisis de los objetos fotográficos y la descripción de las fotografías en redes de significación. Como justificación argumentada de esta propuesta se incorporan una serie de reflexiones sobre diversos temas de la historiografía de la fotografía en el México del siglo XIX.
Las resignificaciones del Nunca Más. Releyendo la violencia política en Argentina
Authors: Crenzel Emilio
Published: January 2016

Este artículo analiza los usos y resignificaciones del informe Nunca Más desde la década del noventa hasta la actualidad. Este informe, publicado en Argentina en 1984, fue elaborado por la Comisión Nacional sobre la Desaparición de Personas (CONADEP), creada en 1983 por el presidente constitucional Raúl Alfonsín para investigar las desapariciones causadas por la represión política. Desde 1995, diversos actores de la sociedad civil y una nueva conducción del Estado impulsaron varias reediciones de este informe que introdujeron a la vez una serie de cambios en la lectura del pasado de violencia política que postulaba el texto original. Dado el carácter canónico que reviste el Nunca Más en Argentina para narrar e interpretar estos hechos, el análisis de estas intervenciones permitirá comprender los cambios y continuidades operados en la propia interpretación de este período que atravesó el país
La estancia: su génesis y su estructura en Córdoba (Gobernación del Tucumánívirreinato del Perú, 1573-1700
Authors: González Navarro Constanza
Published: January 2016

El presente artículo tiene por objeto dar cuenta de la génesis de la estancia colonial y el análisis de su estructura económica en el período comprendido entre 1573 y 1700. El espacio estudiado abarca dos regiones (sierra y planicies) de temprana ocupación en la antigua jurisdicción de la ciudad de Córdoba, perteneciente a la Gobernación del Tucumán y Virreinato del Perú. Este estudio contrastivo –en     tanto tiende a observar las constantes y variantes en las dos regiones analizadas- da cuenta no sólo de los cambios económicos producidos en el espacio como consecuencia de la conquista y colonización española en la zona, sino que pretende aportar algunos lineamientos generales sobre el proceso de integración de la población indígena autóctona a la estructura económica colonial de la jurisdicción cordobesa.
Ruralidad de la Región Centro-Este de México
Authors: López Becerril Iraís Damaris , Romo Lozano José Luis
Published: January 2016

Las zonas rurales han vuelto a ser tema de discusión en el ámbito académico y político, debido a los problemas por los que atraviesan y las funciones que realizan. Una correcta delimitación de ellos es esencial para la efectividad de las políticas; diversos criterios se han utilizado para ello, pero en general, no incorporan varias características importantes que definen lo rural. Este trabajo, hace una breve descripción de un índice de ruralidad propuesto, después el índice se utiliza para caracterizar a la región Centro-Este, la cual es importante económica y socialmente. Es la región más heterogénea, abarca casi todo el rango de ruralidad del país a pesar de la cercanía y concentración de los estados que lo forman. Es una región que muestra la diversidad de espacios rurales que puede haber, además, muestra que algunos estados son rurales en lo social, pero no en lo económico o viceversa.
Los otomíes de ‘La Casona’ en la Colonia Roma
Authors: Valverde López Adrián
Published: January 2016

Este estudio es resultado de un primer análisis de las condiciones sociales y económicas de los otomíes de “La Casona” de la colonia Roma. Quedando pendientes muchas interrogantes por contestar acerca de su organización interna, sus actividades económicas, los problemas que enfrentan cotidianamente, los vínculos familiares con su comunidad de origen, la lucha cotidiana por la preservación de sus costumbres, tradiciones y celebraciones religiosas en el medio urbano. Que en conjunto son aspectos esenciales para entender el proceso de reproducción y cohesión cultural que experimentan en la ciudad de México.
Los comunistas y la publicidad en Costa Rica. El caso del periódico Trabajo (1937-1948)
Authors: Molina Jiménez Iván
Published: January 2016

En 1937, la dirigencia del Partido Comunista de Costa Rica, comenzó a publicar anuncios comerciales en su semanario Trabajo, con el fin de captar fondos que contribuyeran a su financiamiento. La inclusión de publicidad supuso una ruptura con la construcción cultural de este periódico como un órgano alternativo, distinto de la llamada “prensa burguesa”. Los avisos, sin embargo, no lograron convertirse en una fuente decisiva de ingresos, ya que le restaban espacio a las actividades informativas y de propaganda y promovían valores, visiones de mundo y estilos de vida opuestos a los que la izquierda se esforzaba por difundir entre los sectores populares urbanos y rurales.
¿Subversión o hegemonía cultural? Clemencia para esclavos condenados a muerte en Virginia, 1800-1860
Authors: Gurza Lavalle Gerardo
Published: January 2016

La política penal hacia los esclavos en Virginia atravesó un proceso de reformas durante las décadas anteriores a la Guerra Civil. Aunque el código para esclavos era excesivamente severo, en la práctica las autoridades mitigaron su dureza mediante la constante conmutación de las sentencias de muerte a deportación. La pena capital se convirtió en el castigo sólo para los delitos más graves, y la mayor parte de los esclavos condenados a muerte en realidad fueron deportados. La mayoría de los historiadores del Sur estadounidense ha interpretado esta suavización de los castigos como parte del esfuerzo de la clase propietaria de esclavos para incrementar la legitimidad de su sistema social, y también su hegemonía cultural sobre la sociedad sureña en su conjunto.

Desde esta perspectiva, los dueños de esclavos estaban dispuestos a promover reformas de este tipo para disminuir las críticas y cuestionamientos morales dirigidos contra la institución fundamental de su sociedad. Más allá de los ataques externos, a cargo de abolicionistas norteños y europeos, las reformas buscaban disminuir el espacio para las críticas y la disidencia interna, y asegurar el consenso doméstico en torno a la preservación de la esclavitud. Este artículo cuestiona los presupuestos de la “interpretación hegemónica,” y, mediante el análisis detallado de varios casos de crimen esclavo, propone que las actitudes reformistas contenían ideas y actitudes antiesclavistas, así como cierto potencial para subvertir el orden social sureño.
Sobre la portada
Authors: Pensado Leglise María Patricia
Published: January 2016

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…El vivir, mitad pueblerino, mitad ciudadano, en la urbe luminosa y sonriente... La vida cotidiana en Guadalajara en la década de 1930
Authors: Del Palacio Montiel Celia
Published: January 2016

El objetivo del artículo es hacer un esbozo de la vida cotidiana de la ciudad de Guadalajara- epicentro de diversos acontecimientos de importancia nacional- al iniciar la tercera década del siglo XX, momento de transición cuando se puso en marcha el proceso de modernización acelerada que no se detuvo ya en el transcurso del siglo XX. La vida cotidiana se vio afectada por diversos acontecimientos de la década anterior a nivel local –repercusiones de la guerra cristera en la región-, así como nacionales – asesinato de Obregón y gobierno de Calles-, e internacionales –crisis económica de 1929. Sin embargo, la vida cotidiana se vio enriquecida por las nuevas diversiones públicas y la presencia en Guadalajara de un grupo de intelectuales que en los años posteriores, ganaría fama a nivel nacional e internacional. Para dibujar el cuadro de la cotidianidad tapatía, se utilizaron como fuente varios de los periódicos que ahí se publicaban, así como algunas  de las fuentes literarias disponibles.

 

 
Sandra Gayol, Honor y duelo en la Argentina moderna
Authors: Speckman Guerra Elisa , Pulido Esteva Diego
Published: January 2016

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El impacto de la guerra en los comerciantes minoristas de la campaña bonaerense, 1815-1821
Authors: Carrera Julián
Published: January 2016

El proceso revolucionario y las posteriores guerras civiles generaron un fenómeno de militarización asociado al bandolerismo que azotó sobre todo al ámbito rural. En este marco las pulperías de la campaña bonaerense habrían sido afectadas  especialmente por esta situación al igual que las haciendas.  Los registros fiscales  indican que a fines de la década de 1810  se produjo un  marcado descenso del número pulperías de la campaña, muchos pulperos fueron “exonerados” del pago de los impuestos por haber sido saqueados por “tropas federales”, por “montoneras” y en algunos casos por  incursiones indígenas en la frontera. La información sugiere que, tanto para las sociedades indígenas como para los ejércitos intervinientes en la guerra civil, las pulperías eran un blanco seguro, pues allí se proveían de recursos y podían obtener, en algunos casos, dinero líquido.  
El mercado matrimonial de las familias tradicionales argentinas, 1900-1940. Algunas dimensiones y tendencias
Authors: Losada Leandro
Published: January 2016

El artículo estudia el mercado matrimonial delas familias tradicionales argentinas entre 1900y 1940, a partir de una muestra de 550 casamientosy del análisis de sus pautas sociales yculturales. El periodo elegido incluye elmomento de máximo esplendor de esas familiasen la sociedad argentina (entre 1900 y mediadosde la década de 1910 aproximadamente)así como el arco temporal en que se produjo elocaso de su gravitación (las décadas de 1920 y1930). El propósito es pensar la relación entrelas pautas matrimoniales y el ascenso y la declinaciónde la elite tradicional, un problema hastael momento descuidado por la historiografíaargentina.Fecha de recepción:octubre de 2010Fecha de aceptación:febrero de 2011Palabras clave:
Olivia Moreno Gamboa, Una cultura en movimiento. La prensa musical de la ciudad de México (1860-1919)
Authors: Suárez de la Torre Laura
Published: January 2016

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Flavia Fiorucci, Intelectuales y peronismo
Authors: Luciani María Paula
Published: January 2016

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Cómo convertir una empresa en una caricatura. El Ferrocarril de Tlalpan, 1865-1873
Authors: Aguayo Hernández Fernando
Published: January 2016

Este trabajo reseña los avatares de la empresadel Ferrocarril de Tlalpan que formó una sociedadpor acciones para construir la línea del ferrocarrilentre las ciudades de México y de Tlalpanen el año de 1865; describe las dificultades deesa sociedad en tiempos de guerra y las circunstanciaspor las que un proyecto de infraestructura,de mejoras materiales como se les denominabaen la época, sostenido por una amplia basesocial, acabó siendo apropiada por un sector dela elite económica del país. Además de revalorarla propuesta de los empresarios, se pone énfasisen las caricaturas que se hicieron sobre estetema, porque se tiene la hipótesis de que dichosempresarios, sin ser miembros de las elites yhasta teniendo a dos gobiernos distintos en contra,pudieron sortear temporalmente sus dificultadespor el apoyo que les brindó la prensa ylo que se definió en su momento como “la opiniónpública”.
Josefina Zoraida Vázquez (coord.) - Juárez: Historia y mito
Authors: Muñoz Bravo Pablo
Published: January 2016

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Rodrigo Laguarda - La calle de Amberes: gay street de la ciudad de México
Authors: Toussaint Mónica
Published: January 2016

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María Dolores Lorenzo Río, El Estado como benefactor. Los pobres y la asistencia pública en la ciudad de México, 1877-1905
Authors: Gutiérrez Florencia
Published: January 2016

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Isabella Cosse, Karina Felitti y Valeria Manzano (eds.), Los ’60 de otra manera: vida cotidiana, género y sexualidades en Argentina
Authors: Annecchini Mariana
Published: January 2016

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Ana Buriano Castro (Comp.), El ‘espíritu nacional’ del Ecuador católico: artículos selectos de El Nacional, 1872-1875 y Navegando en la borrasca. Construir la nación de la fe en el mundo de la impiedad. Ecuador, 1860-1875, Instituto Mora, México, 2011
Authors: Connaughton Brian
Published: January 2016

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La memoria asediada. La disputa por el presente en la conmemoración del bicentenario
Authors: Ríos Gordillo Carlos Alberto
Published: January 2016

Época de festejo y conmemoraciones, el año 2010 ha sido el momento de la celebración de las independencias en Iberoamérica. "200 años de vida independiente" fueron celebrados a través de una liturgia del pasado y un ritual de la conmemoración. Con ello, el teatro de la memoria nacional actualizaba una estrategia de control social empleada por la Iglesia católica durante siglos: su control sobre el tiempo y el espacio. De este modo, particularmente en México, calendarios y geografías fueron campos de batalla entre el Estado y la Iglesia, pero sobre todo entre aquel y los grupos y movimientos sociales, que al posicionarse frente a las fiestas estatales y a través de estrategias distintas, replantearon la cultura del nacionalismo. Una disputa por la memoria y el pasado, que fue también una disputa por el presente y el futuro alternativos.
Entre Cádiz y Veracruz: la familia Álvarez Campana
Authors: Barrientos Márquez María del Mar
Published: January 2016

Se estudia a la familia Álvarez Campana, asentada en Cádiz y vinculada al comercio americano desde el siglo XVIII. La investigación secentra principalmente en el gaditano José Álvarez Campana. El trabajo desarrolla aspectos dela vida familiar y su relación con la actividadcomercial, la creación de redes sociales y comerciales entre Cádiz y determinadas zonas americanas, en especial con Veracruz.
Prensa y sociedad en las décadas revolucionarias (1910-1940)
Authors: Serna Rodríguez Ana María
Published: January 2016

El artículo aporta una visión panorámica de lahistoria del periodismo en las décadas revolucionarias, considerando el vínculo entre el quehacer periodístico y la sociedad. Se pretende aquíun acercamiento a las diferentes actitudes quecada uno de los gobiernos revolucionarios manifestaron hacia la prensa, los periodistas y la libertad de expresión. Como parte de una investigación más amplia sobre el tema, esta revisiónpropone que la esfera pública mexicana se fortaleció entre l910 y 1940 debido a la fuerza quetomó la idea de la libertad de imprenta y expresión, a la fuerza política adquirida por los periodistas revolucionarios y a causa también de ladebilidad del Estado.
Nacionalismo y reforma electoral en la Argentina del Centenario: Ricardo Rojas en el debate de la Ley Sáenz Peña
Authors: L. Ferrás Graciela
Published: January 2016

El artículo recorre el clima intelectual críticode la reforma electoral de 1912 desde la perspectivanacionalista de Ricardo Rojas. A la crisisdel cosmopolitismo que anuncia en La restauraciónnacionalista (1909) durante el Centenariose le suma, ahora, la crisis del sufragio universal.En 1911 responde a una “encuesta electoral”que realiza el periódico La Nación con unaoriginal propuesta de repartición geográfica dela función electoral dividiendo al país de acuerdoa su “capacidad democrática”. Si esta idea de laciudadanía ha perdido actualidad, no corren elmismo destino los interrogantes que se disparanen relación con la igualdad de condiciones“reales” del ejercicio del sufragio en diálogo conotras reflexiones sobre la nación y la nacionalidad:¿es la “comunidad de ciudadanos” unaparte de la nación o la nación toda?
Problemática sanitaria y conflictos políticos en una ciudad del centro de Veracruz: la epidemia de cólera morbus de 1833 en Xalapa
Authors: Jiménez Marce Rogelio
Published: January 2016

El objetivo de este trabajo es mostrar las acciones que las autoridades del Ayuntamiento de Xalapa realizaron, en materia de políticas sanitarias, para evitar que el cólera morbus provocara graves daños en la ciudad. El que el Cabildo tomara en sus manos el control de la política sanitaria preventiva evidenciaba una nueva visión de la sociedad, en la que el Estado buscaba convertirse en el eje rector de las acciones. Antes de la llegada de la enfermedad, las autoridades municipales dispusieron una serie de medidas tendentes a preservar la salubridad pública, como la publicación de bandos y la formación de comisiones tendentes a preservar la tranquilidad pública, pero una de ellas, su decisión de cambiar la ubicación de los hospitales entre ellos el militar, les generaría conflictos con las autoridades castrenses. La disputa por la posesión del Cuartel Grande, que tanto unos como otros consideraban propio, evidenciaba una lucha de poder, pues las autoridades civiles buscaban imponer sus decisiones sobre las militares.
“Latin American News Agency Should be Formed…” Las agencias de noticias internacionales en el México posrevolucionario, 1920-1934
Authors: Rivera Mir Sebastián
Published: January 2016

En el presente artículo se analizan las agencias de información internacionales vinculadas a los gobiernos posrevolucionarios, entre 1920 y 1934. Este tema no ha sido previamente abordado ni por la historiografía mexicana, ni por los estudios comunicacionales. El objetivo es penetrar en el complejo escenario informativo que se comenzó a construir durante este periodo. Las agencias fueron diseñadas en un contexto donde Estados Unidos realizaba una fuerte campaña propagandística en contra de la revolución mexicana, y los gobiernos de México decidieron contrarrestar esta situación a través de una serie de iniciativas donde las agencias ocuparon un espacio importante. En este escenario se recurrió metodológicamente a la idea de construcción de frentes contrahegemónicos desarrollada por Jorge González. A lo largo de la investigación se distinguieron más de una decena de este tipo de entidades, y se lograron establecer los mecanismos que utilizó el Estado mexicano para desplegar sus objetivos
A conceptualized model of crisis management for small hotel companies
Authors: V. Zhukov Dmitry , Sardo Chiara
Published: January 2016

With the increased globalization and interconnectivity, no economy of the world is able to stay immune to recessions. Similarly, recessions and crises are part of normal business cycle and hospitality industry is not an exception to it. Therefore, development of a crisis management system in the field of hospitality management has become very relevant. Several models have been developed to deal with the necessity of implementing successful crisis management strategies in hotel industry. However, no specific model has been conceptualized for small hotel companies, which, because of their peculiarities, require ad hoc crisis management strategies. Indeed, the small hotel companies are less resistant to crises because of inner characteristics: fewer resources and less specialized management. After reviewing the literature and by taking into consideration the specific characteristics of small hotels, a conceptual model is proposed in this paper. The model has been conceptualized in order to provide a highly flexible and universal tool, that can be adopted by various hotels in different countries and that can address different types of crisis, in different stages by using different approaches. This four stage model has been developed especially regarding the preparation stage and the crisis warnings’ detection: Indeed, preparation is the first step to a successfully crisis management strategy. A further ability of this model is linked to the possibility of working with potential crisis and to turn them into business opportunities.
Direito Penal e Ambiental: Uma Necessária Interlocução
Authors: Mendonça Tarcísio Maciel Chaves de , Custódio Maraluce Maria
Published: January 2016

O presente artigo parte de um referencial garantista de Direito Penal. Utilizando o método comparativo analítico, o presente artigo pretende analisar se a tutela penal do meio ambiente, conforme realizada pela Lei 9.605/98, atende às garantias constitucionais penais. Concluímos que uma eficiente tutela penal do meio ambiente só é possível se levarmos em conta o meio ambiente como um bem jurídico penalmente tutelado a partir de uma concepção antropocêntrica. Significa dizer que seria materialmente típica a ação ou omissão lesiva ao meio ambiente que traria algum reflexo negativo ao homem. Assim, somente as condutas mais lesivas ao meio ambiente ficariam a cargo do Direito Penal. As demais estariam sob o âmbito de incidência do Direito Administrativo.
El Crédito Horario para Actividades de los Representantes de los Trabajadores
Authors: Viña Jordi Garcia
Published: January 2016

Los representantes de los trabajadores en las empresas varían en cada país, siendo dos los principales mecanismos: representantes unitarios y sindicales. Su número suele estar regulado en la Ley y es normal que por negociación colectiva se aumente, así como sus funciones. Para el cumplimiento de las mismas, se les suele conceder un tiempo retribuido, que varía según el número de trabajadores de la empresa. Este período puede ser acumulado, apareciendo los denominados “liberados sindicales” en España, cuyo coste aproximado trata de ser calculado.
Sobrejornada: Um Olhar a Partir da Função Social do Empregador na Prevenção ao Dano Existencial
Authors: Carvalho Robert Carlon de , Séllos-Knoerr Viviane Coêlho de
Published: January 2016

O presente trabalho tem por objetivo avaliar a função social do combate ao dano existencial causado ao empregado celetista em razão da submissão deste ao regime de sobrejornada no trabalho. O estudo aborda temas, como a teoria do contrato de trabalho, as limitações constitucionais e as regras celetistas acerca da jornada de trabalho, em face ao princípio constitucional da dignidade da pessoa humana, os direitos fundamentais, sociais e humanos previstos em favor do trabalhador, como o direito fundamental à saúde, ao lazer e ao convívio social, pressupostos da existência digna. O papel da Organização Internacional do Trabalho para o estabelecimento de uma jornada digna de trabalho e pleno emprego, o valor social do trabalho e da relação de emprego, bem como o dano existencial causados ao trabalhador em consequência do labor em regime de sobrejornada, são apresentados como pressupostos do exercício da função social da empresa.
A portrait oil lamp from Pontes: Possible interpretations and meanings within early Byzantine visual culture
Authors: Petkovic Sofija , Tapavicki-Ilic Milica , Andjelkovic-Grasar Jelena
Published: January 2016

The subject of this paper is a fragmented oil-lamp, discovered at Pontes
(east Serbia) dated to the 6th century, whose handle ending is shaped as a
woman?s head. The question posed in this paper is whether the image of this
woman could be identified as a portrait of some particular person or if it is
just as a pictorial sign with some complicated symbolic meaning. The
suggested identification alludes to the image of some of the empresses from
the second half of the 6th century.
Accessibility of archaeological sites to people with disabilities
Authors: Maslikovic Dejan , Tomic Bojan
Published: January 2016

The accessibility of public facilities and the availability of their content
represent a moral imperative and an obligation to society. Unhindered
movement and the participation in public and cultural life is a legal
obligation under the Constitution and is one of the main postulates of human
rights and freedoms. Also, to deny someone education and their creative
potential is a violation of various laws. People with disabilities are able
to work, earn, produce and engage in all social and economic developments in
a country. In economic terms, their potential is huge. The facilitation of
access to cultural events and archaeological sites presents a great potential
for culture, tourism and economy. The survey on accessibility, conducted with
the management of the sites of Mediana, Caricin Grad, Vrelo-Sarkamen, Ravna,
Gamzigrad, Viminacijum, Vinca and Sirmium is integrated into this paper.
Almost Periodic Solutions for Some Convolution Equations
Authors: Corduneanu Silvia-Otilia
Published: January 2016

We use the theory of Fourier series for almost periodic functions to looking for complex-valued functions f which are almost periodic on R and satisfy the following equation

In this context g and h are almost periodic functions on ℝ and ϕ belongs to L1 (ℝ).
A duality-type method for the obstacle problem
Authors: Merlusca Diana Rodica
Published: January 2016

Based on a duality property, we solve the obstacle problem on Sobolev spaces of higher order. We have considered a new type of approximate problem and with the help of the duality we reduce it to a quadratic optimization problem, which can be solved much easier.
Local Band Spectral Entropy Based on Wavelet Packet Applied to Surface EMG Signals Analysis
Authors: Chen Xiaoling , Xie Ping , Liu Huan , Song Yan , Du Yihao
Published: January 2016

An efficient analytical method for electromyogram (EMG) signals is of great significance to research the inherent mechanism of a motor-control system. In this paper, we proposed an improved approach named wavelet-packet-based local band spectral entropy (WP-LBSE) by introducing the concept of frequency band local-energy (ELF) into the wavelet packet entropy, in order to characterize the time-varying complexity of the EMG signals in the local frequency band. The EMG data were recorded from the biceps brachii (BB) muscle and triceps brachii (TB) muscle at 40°, 100° and 180° of elbow flexion by 10 healthy participants. Significant differences existed among any pair of the three patterns (p < 0.05). The WP-LBSE values of the EMG signals in BB muscle and TB muscle demonstrated a decreased tendency from 40° to 180° of elbow flexion, while the distributions of spectral energy were decreased to a stable state as time periods progressed under the same pattern. The result of this present work is helpful to describe the time-varying complexity characteristics of the EMG signals under different joint angles, and is meaningful to research the dynamic variation of the activated motor units and muscle fibers in the motor-control system.
ERα Mediates Estrogen-Induced Expression of the Breast Cancer Metastasis Suppressor Gene BRMS1
Authors: Ma Hongtao , Gollahon Lauren
Published: January 2016

Recently, estrogen has been reported as putatively inhibiting cancer cell invasion and motility. This information is in direct contrast to the paradigm of estrogen as a tumor promoter. However, data suggests that the effects of estrogen are modulated by the receptor isoform with which it interacts. In order to gain a clearer understanding of the role of estrogen in potentially suppressing breast cancer metastasis, we investigated the regulation of estrogen and its receptor on the downstream target gene, breast cancer metastasis suppressor 1 (BRMS1) in MCF-7, SKBR3, TTU-1 and MDA-MB-231 breast cancer cells. Our results showed that estrogen increased the transcription and expression of BRMS1 in the ERα positive breast cancer cell line, MCF-7. Additionally, the ERα specific agonist PPT also induced the transcription and expression of BRMS1. However, the two remaining estrogen receptor (ER) subtype agonists had no effect on BRMS1 expression. In order to further examine the influence of ERα on BRMS1 expression, ERα expression was knocked down using siRNA (siERα). Western blot analysis showed that siERα reduced estrogen-induced and PPT-induced BRMS1 expression. In summary, this study demonstrates estrogen, via its α receptor, positively regulates the expression of BRMS1, providing new insight into a potential inhibitory effect of estrogen on metastasis suppression.
New Perspectives in the Chemistry of Marine Pyridoacridine Alkaloids
Authors: Plodek Alois , Bracher Franz
Published: January 2016

Secondary metabolites from marine organisms are a rich source of novel leads for drug development. Among these natural products, polycyclic aromatic alkaloids of the pyridoacridine type have attracted the highest attention as lead compounds for the development of novel anti-cancer and anti-infective drugs. Numerous sophisticated total syntheses of pyridoacridine alkaloids have been worked out, and many of them have also been extended to the synthesis of libraries of analogues of the alkaloids. This review summarizes the progress in the chemistry of pyridoacridine alkaloids that was made in the last one-and-a-half decades.
Functional Characterization of a Dihydroflavanol 4-Reductase from the Fiber of Upland Cotton (Gossypium hirsutum)
Authors: Wang Le , Zhu Yue , Wang Peng , Fan Qiang , Wu Yao , Peng Qing-Zhong , Xia Gui-Xian , Wu Jia-He
Published: January 2016

Dihydroflavanol 4-reductase (DFR) is a key later enzyme involved in two polyphenols’ (anthocyanins and proanthocyanidins (PAs)) biosynthesis, however it is not characterized in cotton yet. In present reports, a DFR cDNA homolog (designated as GhDFR1) was cloned from developing fibers of upland cotton. Silencing GhDFR1 in cotton by virus-induced gene silencing led to significant decrease in accumulation of anthocyanins and PAs. More interestingly, based on LC-MS analysis, two PA monomers, (–)-epicatachin and (–)-epigallocatachin, remarkably decreased in content in fibers of GhDFR1-silenced plants, but two new monomers, (–)-catachin and (–)-gallocatachin were present compared to the control plants infected with empty vector. The ectopic expression of GhDFR1 in an Arabidopsis TT3 mutant allowed for reconstruction of PAs biosynthesis pathway and led to accumulation of PAs in seed coat. Taken together, these data demonstrate that GhDFR1 contributes to the biosynthesis of anthocyanins and PAs in cotton.
Synthesis and Evaluation of Aminothiazole-Paeonol Derivatives as Potential Anticancer Agents
Authors: Tsai Chia-Ying , Kapoor Mohit , Huang Ying-Pei , Lin Hui-Hsien , Liang Yu-Chuan , Lin Yu-Ling , Huang Su-Chin , Liao Wei-Neng , Chen Jen-Kun , Huang Jer-Shing , Hsu Ming-Hua
Published: January 2016

In this study, novel aminothiazole-paeonol derivatives were synthesized and characterized using 1H-NMR, 13C-NMR, IR, mass spectroscopy, and high performance liquid chromatography. All the new synthesized compounds were evaluated according to their anticancer effect on seven cancer cell lines. The experimental results indicated that these compounds possess high anticancer potential regarding human gastric adenocarcinoma (AGS cells) and human colorectal adenocarcinoma (HT-29 cells). Among these compounds, N-[4-(2-hydroxy-4-methoxyphenyl)thiazol-2-yl]-4-methoxybenzenesulfonamide (13c) had the most potent inhibitory activity, with IC50 values of 4.0 µM to AGS, 4.4 µM to HT-29 cells and 5.8 µM to HeLa cells. The 4-fluoro-N-[4-(2-hydroxy-4-methoxyphenyl)thiazol-2-yl]benzenesulfonamide (13d) was the second potent compound, showing IC50 values of 7.2, 11.2 and 13.8 µM to AGS , HT-29 and HeLa cells, respectively. These compounds are superior to 5-fluorouracil (5-FU) for relatively higher potency against AGS and HT-29 human cancer cell lines along with lower cytotoxicity to fibroblasts. Novel aminothiazole-paeonol derivatives in this work might be a series of promising lead compounds to develop anticancer agents for treating gastrointestinal adenocarcinoma.
Metabolite Profiling Reveals the Effect of Dietary Rubus coreanus Vinegar on Ovariectomy-Induced Osteoporosis in a Rat Model
Authors: Lee Mee , Kim Hyang , Singh Digar , Yeo Soo , Baek Seong , Park Yoo , Lee Choong
Published: January 2016

The study was aimed at exploring the curative effects of Rubus coreanus (RC) vinegar against postmenopausal osteoporosis by using ovariectomized rats as a model. The investigations were performed in five groups: sham, ovariectomized (OVX) rats without treatment, low-dose RC vinegar (LRV)-treated OVX rats, high-dose RC vinegar (HRV)-treated OVX rats and alendronate (ALEN)-treated OVX rats. The efficacy of RC vinegar was evaluated using physical, biochemical, histological and metabolomic parameters. Compared to the OVX rats, the LRV and HRV groups showed positive effects on the aforementioned parameters, indicating estrogen regulation. Plasma metabolome analysis of the groups using gas chromatography-time of flight mass spectrometry (GC-TOF-MS) and ultra-performance liquid chromatography quadrupole-TOF-MS (UPLC-Q-TOF-MS) with multivariate analysis revealed 19 and 16 metabolites, respectively. Notably, the levels of butyric acid, phenylalanine, glucose, tryptophan and some lysophosphatidylcholines were marginally increased in RC vinegar-treated groups compared to OVX. However, the pattern of metabolite levels in RC vinegar-treated groups was found similar to ALEN, but differed significantly from that in sham group. The results highlight the prophylactic and curative potential of dietary vinegar against postmenopausal osteoporosis. RC vinegar could be an effective natural alternative for the prevention of postmenopausal osteoporosis.
The Local Integrity Approach for Urban Contexts: Definition and Vehicular Experimental Assessment
Authors: Margaria Davide , Falletti Emanuela
Published: January 2016

A novel cooperative integrity monitoring concept, called “local integrity”, suitable to automotive applications in urban scenarios, is discussed in this paper. The idea is to take advantage of a collaborative Vehicular Ad hoc NETwork (VANET) architecture in order to perform a spatial/temporal characterization of possible degradations of Global Navigation Satellite System (GNSS) signals. Such characterization enables the computation of the so-called “Local Protection Levels”, taking into account local impairments to the received signals. Starting from theoretical concepts, this paper describes the experimental validation by means of a measurement campaign and the real-time implementation of the algorithm on a vehicular prototype. A live demonstration in a real scenario has been successfully carried out, highlighting effectiveness and performance of the proposed approach.
Laterally Driven Resonant Pressure Sensor with Etched Silicon Dual Diaphragms and Combined Beams
Authors: Du Xiaohui , Liu Yifang , Li Anlin , Zhou Zhou , Sun Daoheng , Wang Lingyun
Published: January 2016

A novel structure of the resonant pressure sensor is presented in this paper, which tactfully employs intercoupling between dual pressure-sensing diaphragms and a laterally driven resonant strain gauge. After the resonant pressure sensor principle is introduced, the coupling mechanism of the diaphragms and resonator is analyzed and the frequency equation of the resonator based on the triangle geometry theory is developed for this new coupling structure. The finite element (FE) simulation results match the theoretical analysis over the full scale of the device. This pressure sensor was first fabricated by dry/wet etching and thermal silicon bonding, followed by vacuum-packaging using anodic bonding technology. The test maximum error of the fabricated sensor is 0.0310%F.S. (full scale) in the range of 30 to 190 kPa, its pressure sensitivity is negative and exceeding 8 Hz/kPa, and its Q-factor reaches 20,000 after wafer vacuum-packaging. A novel resonant pressure sensor with high accuracy is presented in this paper.
Impact of Service-Learning on Leadership and an Interest in Social Justice
Authors: Barnes Margaret
Published: January 2016

Background:

Many articles describe how service-learning has been implemented, but few studies have demonstrated its effectiveness.

Method:

A service-learning component was added to a course in a registered nurse-to-baccalaureate degree (RN-to-BSN) completion program. The service-learning component included a 5-hour service requirement and class discussions. The purpose of this study was to evaluate service-learning's impact on postlicensure RN-to-BSN students' self-evaluation of their leadership skills and their interest in social justice. This study used a quantitative, pretest–posttest control group design and a Likert scale survey.

Results:

Variations in precourse and postcourse responses of the control group did not demonstrate a measurable effect; responses of the service-learning group revealed a small effect size for both the leadership construct and the social justice construct.

Conclusion:

This study was unique in that it addressed nontraditional RN-to-BSN students in an accelerated program, 70% of whom were taking the course in an online format. [
J Nurs Educ
. 2016;55(1):24–30.]
Gendered Representations of Fandom
Authors: Gürsimsek Ödül A.
Published: January 2016

Lost is a transgeneric, transmedia television drama that aired from 2004 to 2010, a period which coincided with the emergence of several participatory online Web 2.0 platforms including blogs, forums, YouTube, and Twitter. Thus, Lost audiences used various platforms to form communities and discuss the show. This chapter analyzes the discursive practices of audiences that compose the transgeneric audience discourse of Lost, and the tensions that arise when romance fans and science fiction/mystery fans are situated in conflicted positions regarding certain storylines. The analysis provides a critical discursive perspective that demonstrates that gender dynamics plays a role in interpreting the material related to fiction and the points of view of the other fan groups. The audience discourse that is shaped and negotiated by men and women who deliberate the so-called gendered interests in online mixed-gender platforms offer insights into how female audiences use online discussion platforms to empower themselves by constructing their identities as equal audience groups with legitimate interests.
Access And Utilization of ICTs by Rural Women in Kenya
Authors: Rukwaro Monica W. , Bii Harrison
Published: January 2016

This chapter on access and utilization of ICTs by rural women looks at the conceptualization of ICTs. Delves into the women's extent of access and utilization of ICTs. It also examines the numerous efforts being made by various bodies to ensure greater access and utilization. The Chapter also looks the hindrances to access and utilization of ICTs and proffers suggestions on the ways to improve access and utilization of these technologies. Further research directions have also been pointed out. The authors analyze literature and reflect on their experiences and their wide interaction with rural women in their diverse daily occupations and their use of ICTs.
Digital Leisure or Digital Business?
Authors: Wilson Joseph , Lawan Aisha Kolo
Published: January 2016

The fourth world conference on women in Beijing in 1995 was a springboard for women acceptance to explore various media possibilities to enhance their global visibility for societal recognition, address the negative media portrayal of women, and strengthen the gender equality struggles. Their platform for action on women and the media was to strategically increase the participation and access of women to expression and decision-making in and through the media and new technologies of communication. These declarations and strategies were clear indications and a call for creating new avenues for expression and participation for the purpose of empowering women. These plans of action and adoption of new technologies of communication must translate into relevant engagement with these technologies to be able to achieve the set goals. Engaging with technologies for leisure purposes (digital leisure) are likely to be of little significance to serious Internet activities relevant to women empowerment drive (digital business). The purpose for which women engage these new technologies should reflect issues that are in tandem with women empowerment drive. This Chapter examined what area Nigerian women are engaging the Internet. Findings showed that more Nigeria women access the Internet through mobile devices such as smartphones and tablets. Nigerian women engage the Internet for both digital leisure and digital business but they do more leisure-based Internet activities than serious activities that facilitate women empowerment (their Internet activities are more leisure oriented than business oriented) The women Internet empowerment drive can only be realised if Nigerian women up their game in digital business activities on the Internet.
The Use of Mobile Health Applications for Quality Control and Accreditational Purposes in a Cytopathology Laboratory
Authors: Stavros Archondakis , Vavoulidis Eleftherios , Nasioutziki Maria
Published: January 2016

Over the last decade, the practice of clinical cytopathology was dramatically influenced by the wide implementation of informatics and computer sciences into the laboratory workflow. New applications, especially in the field of Mobile Health technology, will enhance the opportunities for improvement in the field of cytological data management and sharing. In this chapter, the authors present a thorough research of mobile applications related to cytopathology and try to foresee applications that, if available on mobile devices, may benefit the modern cytopathology laboratory and its clients. Also, the feasibility of adopting mobile applications for inter-laboratory comparisons, proficiency testing and diagnostic accuracy validation is examined. Finally, the role of mobile applications for providing or/and enhancing the existing laboratory capabilities through educational training and other research activities is investigated. Economic or medicolegal aspects of the expected wide adoption and implementation of mobile applications in the field of Cytopathology will also be covered.
NEWSLETTER - January 2008
Authors: Griffo Raffaele
Published: January 2016

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Echocardiography and Pulmonary Arterial Hypertension
Authors: Bossone Eduardo , Citro Rodolfo , Ruggiero Alberto , Kuersten Bettina , Gregorio Giovanni , Blasi Francesco , Allegra Luigi
Published: January 2016

Pulmonary Arterial Hypertension (PAH) is an heterogeneous condition brought on by a wide range of causes. It is characterized by structural changes in small pulmonary arteries, that produce a progressive increase in pulmonary artery pressure and pulmonary vascular resistance, ultimately leading to right ventricle failure and death. Given the non-specific nature of its early symptoms and signs, PAH is often diagnosed in its advanced stages. Along with a careful clinical assessment and an accurate electrocardiogram/Chest X-ray interpretation, echocardiography is an essential test in the evaluation of patient with PAH. In fact it not only provides an accurate estimate of pulmonary pressure at rest and during exercise, but may also help to exclude any secondary causes, predict the prognosis, monitor the efficacy of specific therapeutic interventions and detect the preclinical stage of the disease.
The Italian Survey on Cardiac Rehabilitation - 2008 (ISYDE-2008). Part 3. National availability and organization of cardiac rehabilitation facilities. Official report of the Italian Association for Cardiovascular Prevention, Rehabilitation and Epidemiolog
Authors: Tramarin Roberto , Ambrosetti Marco , De Feo Stefania , Piepoli Massimo , Riccio Carmine , Griffo Raffaele
Published: January 2016

From January 28th to February 10th 2008, the Italian Association for Cardiovascular Prevention, Rehabilitation and Epidemiology (IACPR-GICR) conducted the ISYDE- 2008 study, the primary aim of which was to take a detailed snapshot of cardiac rehabilitation (CR) provision in Italy – in terms of number and distribution of facilities, staffing levels, organization and setting – and compare the actual CR provision with the recommendations of national guidelines for CR and secondary prevention. The secondary aim was to describe the patient population currently being referred to CR and the components of the programs offered. Out of 190 cardiac rehabilitation centers existing in Italy in 2008, 165 (87%) took part in the study. On a national basis, there is one CR unit every 299,977 inhabitants: in northern Italy there is one CR unit every 263,578 inhabitants, while in central and southern Italy there is one every 384,034 and 434,170 inhabitants, respectively. The majority of CR units are located in public hospitals (59%), the remainder in privately owned health care organizations (41%). Fifty-nine percent are located in hospitals providing both acute and rehabilitation care, 32% are in specifically dedicated rehabilitation structures, while 8% operate in the context of residential long term care for chronic conditions. Almost three-quarters of CR units currently operating are linked to dedicated cardiology divisions (74%), 5% are linked to physical medicine and rehabilitation divisions, 2% to internal medicine, and 19% to cardiac surgery and other divisions. Inhospital care is provided by 62.4% of the centers; outpatient care is provided on a day-hospital basis by 10.9% of facilities and on an ambulatory basis by 20%. The CR units are led in 86% of cases by a cardiologist and in only 14% of cases by specialists in internal medicine, geriatrics, physical medicine and rehabilitation, pneumology or other disciplines. In terms of staffing, each cardiac rehabilitation unit has 4.0±2.7 dedicated physicians (range 1-16, mode 2), 10.1±8.0 nurses, 3.3±2.5 physiotherapists (range 0 – 20; 16% of services have no physiotherapist in the rehabilitation team), 1.5±0.8 psychologists, and a dietitian (present in 62% of CR units). Phase II CR programs are available in 67.9% of cases in residential (inpatient) and in 30.9% of cases in outpatient (day-hospital and ambulatory) settings. Phase III programs are offered by 56.4% of the centers in ambulatory outpatient regime, and on an at home basis by 4.8% with telecare supervision, 7.3% without. Long term secondary prevention follow up programs are provided by 42.4% of CR services.
Erythropoietin: a new perspective in cardiovascular therapy
Authors: Raddino Riccardo , Robba Debora , Caretta Giorgio , Bonadei Ivano , Teli Melissa , Zanini Gregoriana , Madureri Alberto , Vizzardi Enrico , Dei Cas Livio
Published: January 2016

Erythropoietin is a hormone produced by the kidney, which regulates proliferation, differentiation and maturation of red cells. Recombinant human EPO (rH-EPO) is well known to correct anaemia in patients with chronic renal failure in terminal stage. However, recent studies showed the existence of several not haematopoietic effects of erythropoietin. EPO receptors have been found to be expressed in several tissues, included the cardiovascular system. An increase in cardiac systolic function has been observed in patients with chronic heart failure treated with EPO. Other beneficial effects appear to be related to the pro-angiogenic properties on endothelial cells and could be useful for treatment of ischemic heart disease. These findings suggest that EPO could provide potential therapeutic benefits in the management of cardiovascular diseases beyond anaemia correction. This review focuses its attention on the pleiotropic effects of EPO and its future promising applications in cardiovascular pathology.