bluuebunny/crossref_metadata_2025 huggingface dataset:
Systemic features of the formation of mental models behavior of people in socio-economic relations
Authors: Mokiy Mikhail S. , Azoeva Olga V.
Published: July 2024

The article substantiates the thesis that management of human behavior is the management of each person behavior. In turn, each person behavior depends on the individual mental model formed in his mind. It is shown that the existence of public institutions as rules of conduct and the enforcement of their execution is a systemic necessity and they are established on the basis of values and goals of those people who establish them. The article proposes a hierarchy of behavior attributes in an individual mental model that defines human behavior. It is shown that behavior style of each person is the result of a constant comparison of rules and goals of society development with individual goals. Man as a system strives for stability and self-preservation. The set of values formed in an individual mental model determines the parameters of sustainability and self-preservation in the form of a set of needs, a range of benefits and ways to obtain them. The successful development of the system is possible only with the joint directed development of each system element. It is shown that the systemic goal of socio-economic relations is to increase well-being of each person as a creator of goods and his household, as well as the comprehensive development of each person as a member of society. The systemic need for management consists in forming a set of values based on these goals, which means a set of needs, and changing the rules for the creation, distribution and exchange of goods corresponding to these goals. It is shown that only in this case the common goals underlying the formation of an individual mental model will coincide with the goals of human development as a system and ensure harmonious behavior of people. Otherwise, people use public conformity for self-preservation and stability, or nonconformism as a style of behavior aimed at realizing values in an individual mental model.
Estrategia para la ubicación de sitios preliminares de disposición final con y sin manejo integral de residuos sólidos utilizando ArcGIS – caso de estudio: municipios de Panamá y San Miguelito
Authors: Monterrey Surhay , Morán Grethel , Colmenares María , Montero Alejandra , Domínguez Viccelda
Published: July 2024

Actualmente Panamá presenta una problemática con la disposición final de los residuos sólidos. En el 2021, la AAUD estableció que el relleno sanitario Cerro Patacón no contaba con las medidas necesarias para seguir operando por el incumplimiento de los términos legales y técnicos del manejo y disposición de los residuos. Sin embargo, no es factible clausurar de forma precipitada   el relleno sanitario; ya que, este le brinda cobertura a dos zonas de mayor población de la República de Panamá, los cuales son los municipios de Panamá y San Miguelito. Es por esto por lo que el objetivo de esta investigación es establecer una estrategia para ubicar sitios preliminares de disposición final implementando la herramienta ArcGIS, basados en los parámetros establecidos en los criterios técnicos legales del país (artículo 5 del                Decreto Ejecutivo 275 del 2004), como alternativa a la problemática actual del relleno sanitario Cerro Patacón, mediante la implementación de estrategias de reducción de residuos por medio del manejo integral, contribuyendo así con ocho (8) objetivos de                      Desarrollo Sostenible de las Organización de las Naciones Unidas para el 2030. Los sitios preliminares propuestos fueron: Bayano 1, Bayano 2 y Cerro Bandera; siendo el último el sitio preliminarmente óptimo, al cumplir con la mayoría de los parámetros a evaluar a través de la tecnología ArcGIS y los métodos de validación cualitativa ambiental y de factores de ponderación como: distancia poblacional, ubicación de aeropuertos, lejanía a líneas de conducción de agua potable, vías de acceso, entre otros.
PENDEKATAN HERMENEUTIKA AMINA WADUD: GENDER DALAM KONSEP HUSBAND AND WIFE
Authors: Munirah Munirah , Umi Umi sumbulah
Published: July 2024

Islam adalah agama yang sangat menjunjung tinggi keadilan tanpa membedakan pria maupun wanita. Akan tetapi sejalan dengan perkembangan zaman, keterbatasan dan perbedaan pemahaman dalam memahami agama menjadi momok yang mengagungkan gender tertentu dan merendahkan lainnya. Ketimpangan peran sosial berdasarkan gender masih tetap dipertahankan dengan dalih doktrin agama. Agama dilibatkan untuk melestarikan kondisi di mana kaum perempuan tidak menganggap dirinya sejajar dengan laki-laki. Tidak mustahil di balik kesadaran teologis ini terjadi manipulasi antropologis bertujuan untuk memapankan struktur patriarki, yang secara umum merugikan kaum perempuan dan hanya menguntungkan kelas-kelas tertentu dalam masyarakat. Melihat pergeseran paradigma ini, Amina Wadud berusaha untuk mendongkrak pemahaman yang telah menyimpang jauh dari penghargaan Al-Qur’an terhadap wanita.
INTERPRETASI MAKNA SULHU DALAM PENYELESAIAN KASUS NUSYUZ SUAMI PERSPEKTIF TAFSIR
Authors: Syafi’i  , Mochammad Novendri S
Published: July 2024

In Islamic law domestic conflict is referred to by the term nusyuz. The concept was taken from the Q.S. An-Nisa': 34 and 128. From this verse, when a comparison is made between the wife's nusyuz settlement and the husband, there is a difference in settlement pattern, both of which indicate discrimination against the wife. Therefore, it is necessary to examine the meaning of the sulhu in depth by interpreting the meaning of the sulhu in the settlement of the case from the nusyuz husband's interpretation perspective. This study used the content analysis method, a research technique to draw conclusions from legitimate data by considering the context. As for the results of this study, the reason for using the word "sulhu" in the settlement of the nusyuz husband is because it gives the parties freedom and opportunity to think about the best way to resolve their disputes even to cancel each other's rights from the latter, so that they can be able to do so. satisfying the parties to the dispute, bringing peace of mind and strengthening the bonds of friendship. In the settlement of the nusyuz wife according to the duties of a man in the family is as a leader who aims to protect and protect his family by educating and teaching it. As for the nusyuz husband, by way of sulhu (peace). Even when viewed from the asbabun-nuzul verse it is only one example of completion of the sulhu. Furthermore, the wife can also choose another way in order to benefit both. Which is essentially that sulhu is a very wise way for women to solve the nusyuz husband problem in the various ways they agree. It means that it is not true that sulhu makes women's position weak or there is discrimination against women, but sulhu is actually glorifying women themselves.
BAHASA SEBAGAI ALAT PEMBERDAYAAN SISWA AGAR MANDIRI DALAM LINGKUNGAN PESANTREN
Authors: Eka Putri Vania  , Moh. Ahsan Shohifur Rizal  , Kholik
Published: July 2024

This research is an in-depth effort to explore the role of language as a tool for empowering Islamic boarding school students to achieve an optimal level of independence. In the context of Islamic boarding schools, language is not only interpreted as a medium of communication, but also as a crucial instrument in forming character and understanding religious values. By integrating learning methods that focus on understanding religion in the context of everyday life, the aim of this research is to provide new insights in developing student empowerment strategies. The importance of understanding religious values permeated through language is the main focus, and this research seeks to make a significant contribution by detailing effective strategies to achieve this goal. It is hoped that the findings of this research can become a basis for Islamic boarding schools in designing learning that not only prioritizes aspects of student independence, but also integrates religious values as a whole in the daily lives of Islamic boarding school students.
Perbandingan dan Efek Populasi Ikan di Pantai Bunder Desa Bangsring Kecamatan Wongsorejo Kabupaten Banyuwangi
Authors: Wahid Abdur Rohman , Sjakoer Nour Athiroh Abdoes , Hayati Ari
Published: July 2024

Pantai Bangsring mempunyai potensi sumberdaya alam bahari yang unik dan pantai yang asri.Alam bawah laut. Pantai Bangsring juga mempunyai wahana-wahana yang dimainkan oleh pengunjung salah satunya snorkling, pantai Bangsring sendiri mempunyai beberapa sport snorkling dimana sprot tersebut juga ada yang sering di datangi dan jarang di datangi, jadi para pengunjung atau penikmat snorkling ada yang belom menikmati sport yang tidak sering di datangi pengunjung. Tujuan daripenelitian ini untuk mengetahui perbandingan ikan antara sport yang sering di datangi pengunjung dan yang tidak sering di datangi pengunjung serta apakah aktivitas antropogenik juga membuat ikan ikan yang berada di dua sport tersebut hilang. Metode yang saya lakukan menggunakan metode tehnik pourpose simple dimana penentuan stasiun yang saya ambil ditentukan oleh saya sendiri karna mengapa stasiun yang berada di situ ada yang jarang di datangi pengunjung. Hasil dari penelitian ini adalah ditemukan 29 spesies antara dua sport yang telah di tentukan tersebut. Untuk mengurangnya ikan yang berada di Pantai Bangsring karena perubahan iklim yang tidak terduga dan aktivitas para pengunjung yang menginjak terumbu karang dan membuat karang itu mati sehingga hilangnya ikan-ikan yang berada di pantai Bangsring.
Uji Efektifitas Ekstrak Daun Sirih Hijau (Piper betle L) dan Ekstrak Daun Pepaya (Carica papaya L) Terhadap Mortalitas Larva Nyamuk Aedes aegypti L
Authors: Atini Blasius , Rika Yulianti , Ledheng Ludgardis
Published: July 2024

Dengue fever is an infectious disease caused by a virus transmitted by the mosquito Aedes aegypti L. One of the DBD vector eradication programs involves using synthetic insecticides. The use of synthetics (chemicals) is known to be very effective, relatively easy, and practical, but it has a negative impact on the environment. One is using natural insecticides; in this way, it is expected to inhibit the life cycle of mosquitoes before they develop to adulthood. The natural insecticide used is a plant insecticide from the green leaf plant (Pipper betle L) and the leaf of the papaya (Carica papaya L), because both plants have a secondary metabolite compound that can inhibit the growth of the larvae of the mosquito Aedes aegypti L. The method in this study is a simple experimental design with a complete random effect (RAL) to see the effectiveness of extracts of green coriander leaves and papaya leaves. With each extract being tested for its effectiveness, three treatments and one control were performed. The research using the extraction method, i.e., the mazeration method of observing larval death, was conducted for 1 hour of observation to determine the effectiveness of treatment extracts tested using Anova level 5% and probit analysis to determine LC50 values. The average mortality of mosquito larvae (Aedes aegypti L) after treatment with ethanol extract of green syrup leaves at a concentration of 60% at 100%, at a concentration of 40% at 87%, and at a concentration of 20% at 47%.
Penggunaan mesin produksi dan penerapan K3 untuk mengurangi resiko kecelakaan kerja pada UMKM
Authors: Artiyani Anis , Budiharso Hery Setyo , Sari Sanny Andjar , Anggorowati Dwi Ana , Setyawati Harimbi , Rahman Nanik Astuti , Ashari Mohammad Ibrahim
Published: July 2024

Kegiatan pengabdian kepada masyarakat dalam konteks Usaha Mikro, Kecil, dan Menengah (UMKM) di sektor manufaktur memiliki relevansi yang signifikan dalam mendukung perekonomian lokal. Salah satu contohnya adalah Bengkel Las Karmannaut yang berlokasi di Perumahan Citra Pesona Bumi Raya blok F5 no. 18. Untuk meningkatkan produktivitas dan keselamatan kerja di UMKM ini, Tim Pelaksana Pengabdian dari Institut Teknologi Nasional Malang telah menyelenggarakan kegiatan Workshop dan Pelatihan guna Peningkatan Pengetahuan tentang Penggunaan Mesin Produksi pada UMKM Bengkel Las. Tujuan kegiatan ini adalah untuk memberikan pelatihan kepada UMKM Bengkel Las Karmannaut tentang operasional penggunaan mesin bubut, teknik pemeliharaan mesin, serta kesadaran akan keselamatan kerja bagi para pekerja di Bengkel Las Karmannaut. Pelaksanaan kegiatan ini menggunakan metode Participatory Action Research (PAR) dan Foccus Grup Discussion (FGD) guna penyelesaian masalah yang dihadapi mitra pengabdian terutama tentang penggunaan dan pemeliharaan mesin bubut, serta penerapan K3 bagi UMKM Bengkel Las.Pelatihan mesin bubut menjadi penting sebagai investasi jangka panjang bagi pelaku usaha bengkel untuk meningkatkan keterampilan tenaga kerja, meningkatkan efisiensi operasional, dan tetap bersaing dalam industri manufaktur yang dinamis.Melalui pelatihan ini, diharapkan UMKM dapat mengoptimalkan proses produksi mereka secara efisien dan aman, sehingga berkontribusi positif terhadap pertumbuhan ekonomi lokal serta kesejahteraan masyarakat sekitar Kelurahan Kedungkandang.
Membangun mindset bisnis halal melalui kesadaran halal untuk UMKM sektor kuliner
Authors: Adiba Elfira Maya , Amir Faizal
Published: July 2024

Usaha Mikro, Kecil, dan Menengah (UMKM) menghadapi permasalahan dalam bisnisnya, salah satunya adalah masalah pertumbuhan laba. Salah satu solusi dari permasalahan tersebut yaitu dengan membuat produk UMKM lebih berdaya saing dengan membuat mindset berbisnis halal yang melalui sertifikasi halal. Bisnis dalam Islam tidak hanya mencari keuntungan semata namun perlu mengikuti petunjuk Islam untuk mencapai keberkahan. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan kesadaran halal pelaku usaha agar semakin berminat melakukan sertifikasi halal yang dapat dimanfaatkan untuk menjadi keunggulan kompetitif dalam berbisnis. Metode yang digunakan menggunakan pendekatan participatory action research (PAR) yang meliputi ceramah, diskusi, dan pendampingan UMKM kuliner di Desa Majungan. Penduduk setempat mayoritas adalah petani dan nelayan, sehingga jumlah UMKM kuliner yang berhasil dikumpulkan juga terbatas yaitu sebanyak 5 UMKM. Hasil dari uji beda literasi halal didapatkan bahwa tidak ada perbedaan literasi halal sebelum dan sesudah dilaksanakan kegiatan transfer keilmuan. Hasil dari analisis deskriptif kesadaran halal pelaku usaha ada pada kategori sangat baik. Hasil dari kegiatan pendampingan ini juga didapatkan tiga UMKM yang mendaftarkan sertifikasi halal. Kegiatan selanjutnya yaitu perlu adanya pendampingan strategi pemasaran berbasis digital untuk mengikuti tren pasar serta perluasan area pengabdian masyarakat untuk mengajak UMKM di Madura untuk mendaftarkan produknya sertifikasi halal sehingga produk UMKM memiliki daya saing dan keunggulan kompetitif.
Yoga prenatal dalam menurunkan nyeri punggung pada ibu hamil trimester III
Authors: Susanti
Published: July 2024

Kehamilan melibatkan berbagai perubahan fisiologis antara lain perubahan fisik, perubahan sistem pencernaan, sistem pernafasan, sistem saluran kemih, sistem muskuloskeletal dan sirkulasi. Proses adaptasi tidak jarang ibu mengalami rasa tidak nyaman salah satunya adalah nyeri punggung, meskipun nyeri punggung bersifat fisiologis namun tetap perlu diberikan pengobatan seperti prenatal yoga. Pre-experimental design dengan desain one group pretest-posttest design. Sampel penelitian adalah ibu hamil yang telah memasuki usia kehamilan trimester III (28-40 minggu) yang berkunjung ke TPMB A, Kecamatan Koja, Jakarta Utara pada bulan Maret yang berjumlah 30 responden dengan menggunakan teknik purposive sampling. Instrumen penelitian menggunakan lembar observasi. Data yang digunakan adalah data primer yang dianalisis dengan menggunakan uji berpasangan sample t-test. Analisis univariat didapatkan ibu hamil trimester III sebelum diberikan prenatal yoga rata-rata nyeri pinggang sebesar 6,13, dan setelah diberikan prenatal yoga rata-rata nyeri punggung sebesar 2,03. Hasil analisis bivariat menunjukkan adanya pengaruh prenatal yoga terhadap penurunan nyeri punggung pada ibu hamil trimester III dengan p value = 0,000. Adanya pengaruh prenatal yoga terhadap penurunan nyeri punggung pada ibu hamil trimester III. Diharapkan ibu hamil trimester III dapat mengikuti atau mempraktekkan gerakan-gerakan prenatal yoga secara rutin minimal 1-2 kali dalam seminggu dengan prinsip aman dan nyaman.
Hubungan Komunikasi Interpersonal Perawat dengan Kepuasan Pasien
Authors: Hamdiah Dedeh , Budiyanto Agung
Published: July 2024

Pusat pelayanan kesehatan di Indonesia semakin hari semakin bertumbuh dan berkembang secara pesat sehingga banyak pilihan pelayanan kesehatan yang dapat pasien percayakan dalam melakukan perawatan kesehatannya. Apa yang diharapkan pasien dalam memilih pelayanan kesehatan adalah kemampuan petugas yang cepat dan tanggap terhadap keluhan pasien serta mampu menghadapi keluhan pasien secara profesional. Tujuan penelitian ini untuk mengetahui hubungan antara komunikasi interpersonal perawat dengan kepuasan pasien di Puskesmas Pontang tahun 2023. Metode korelasi dengan pendekatan cross-sectional digunakan dalam penelitian ini. Dari 150 pasien rawat inap sebagai populasi, 75 responden dilibatkan sebagai sampel dengan menggunakan rumus Slovin. Pengumpulan data dilakukan dengan wawancara, observasi, dan kuesioner. Hasil penelitian menunjukkan sebagian besar responden menyatakan komunikasi interpersonal perawat baik (62,7%) dan sebagian besar responden menyatakan kepuasan pasien di unit rawat inap tidak puas (54,7%). Hasil uji statistik menggunakan uji chi-square memperoleh nilai p 0,024 (p<α), artinya ada hubungan antara komunikasi interpersonal perawat dengan kepuasan pasien di unit rawat inap Puskesmas Pontang. Peneliti menyimpulkan bahwa perlu penguatan pada perawat rawat inap seperti pelatihan tentang komunikasi interpersonal dan service excellence.
Organoleptic, Chemical, and Microbial Characteristics of Extrudate Products from the Synthesis of Shrimp Shell and Milk Bones Waste as a High Source of Protein and Calcium
Authors: Moch Yazid Abdul Zalalil Amin  , Lutfi Firnanada  , Fauziyyah Athiefah
Published: July 2024

The high level of shrimp and milkfish commodity waste which is not managed further in the small and medium enterprise industry in East Java can cause various problems, one of which is the aspect of health and environmental pollution. Therefore, innovative efforts are needed to manage this waste by turning it into an extruded snack product. This research will use an experimental study by starting with the synthesis of shrimp shell and bone waste into flour which is then mixed with corn granules and processed using an extruder machine according to the specified formulation (70:30, 50:50, 30:70). After that, the extrudate product will be analyzed in the laboratory to carry out organoleptic tests, chemical tests and microbial tests. The organoleptic test results obtained were then analyzed using the variance analysis method and the Duncan advanced test, while the chemical test and microbial test results were carried out with descriptive analysis by comparing the SNI 01-2886-2015 standard regarding extruded snacks. The results of this research describe the organoleptic, chemical and microbial characteristics of the extrudate product from the synthesis of milkfish bone shrimp shell waste combined with corn granules based on the specified formulation, namely with proportions of 70:30, 50:50, 30:70 so that it can be determined which formulation is best.
Analysis of User Satisfaction in the Visiting Jogja Application with the Technology Acceptance Model (TAM) Method toward Increasing the Number of Tourists in the Special Region of Yogyakarta
Authors: Ardliani Latifah , Pujiarni Hapsari Putri , Ginting Ginta
Published: July 2024

The development of technology in the current era is very fast, one of the proofs of this technological development is Android. Android has many benefits that can help people's lives. The use of this android is not only used by the community but by an agency, namely the Yogyakarta Tourism Office. Using Android can help make it easier for tourists to travel in Yogyakarta. The Yogyakarta Tourism Office then launched a tourism application called Visiting Jogja. In using the application tourists will feel a certain emotion of satisfaction. Differences in application user satisfaction have an impact on increasing the number of tourists in the Special Region of Yogyakarta. This study aims to analyze user satisfaction in the Visiting Jogja application for increasing the number of tourists in the Special Region of Yogyakarta. The method used in this research is a descriptive quantitative analysis of the Technology Acceptance Model (TAM) by collecting data through questionnaires and observation. The results of this study are data on the relationship between user satisfaction of the Visit Jogja application and an increase in the number of tourists in the Special Region of Yogyakarta so that it can be a reference for the government to increase user satisfaction so that Yogyakarta tourism develops rapidly.
PARA ALÉM DO CANTEIRO DE OBRAS
Authors: Rocha Carlos
Published: July 2024

Este estudo analisou a relação que existe entre a vulnerabilidade profissional e a vulnerabilidade da vida pessoal de profissionais da construção civil. O objetivo era fazer uma análise compreensiva, baseada em entrevistas com trabalhadores atuantes no setor construtivo, tanto com vínculos trabalhistas formais quanto informais. O sentido era captar as percepções dos sujeitos e dar espaço para o relato de suas vivências. Os entrevistados foram questionados acerca de vínculos trabalhistas, a relação com os engenheiros civis e conhecimentos acerca dos sindicatos trabalhistas. Como resultado, a pesquisa mostrou como o cenário de vulnerabilidade em que os trabalhadores já estiveram ou estão inseridos se perpetua devido ao silenciamento do tema tratado. Os próprios trabalhadores buscam meios de encobrir, até para si próprios, as condições do contexto em que atuam, como a instabilidade de renda ou a precariedade de assistências por parte dos órgãos governamentais. Por fim, o presente artigo apresenta alternativas para mitigar a problemática evidenciada, por intermédio de ações eficazes dos sindicatos em favor dos trabalhadores e a abordagem da temática na formação dos acadêmicos em Engenharia Civil e cursos técnicos de Edificações, dado seu papel fundamental como futuros profissionais.
In silico studies on leishmanicide activity of limonoids and fatty acids from Carapa guianensis Aubl
Authors: de Barros Renilson Castro , Araujo da Costa Renato , Farias Suelem Daniella Pinho , de Albuquerque Kelly Cristina Oliveira , Marinho Andrey Moacir R. , Campos Marliane Batista , Marinho Patrícia Santana Barbosa , Dolabela Maria Fani
Published: July 2024

The oil of Carapa guianensis showed leishmanicidal activity, with its activity being related to limonoids, but fatty acids are the major constituents of this oil. The present study evaluated the physicochemical, pharmacokinetic, and toxicity profiles of limonoids and fatty acids already identified in the species. Based on these results, 2 limonoids (methyl angosinlate, 6-OH-methyl angosinlate) and 2 fatty acids (arachidic acid; myristic acid) were selected for the prediction of possible targets and molecular docking. Included in this study were: Gedunin, 6α-acetoxygedunin, Methyl angosenlato, 7-deacetoxy-7-oxogedunin, Andirobin, 6-hydroxy-angolensate methyl, 17β-hydroxyazadiradione, 1,2-dihydro-3β-hydroxy-7-deacetoxy-7-oxogedunin, xyllocensin k, 11beta-Hydroxygedunin, 6α,11-11β-diacetoxygedunin, Oleic Acid, Palmitic Acid, Stearic Acid, Arachidic Acid, Myristic Acid, Palmitoleic Acid, Linoleic Acid, Linolenic Acid, and Beenic Acid. Regarding physicochemical aspects, fatty acids violated LogP, and only limonoid 11 violated Lipinski’s rule. A common pharmacokinetic aspect was that all molecules were well absorbed in the intestine and inhibited CYP. All compounds showed toxicity in some model, with fatty acids being mutagenic and carcinogenic, and limonoids not being mutagenic and carcinogenic at least for rats. In in vivo models, fatty acids were less toxic. Molecular dockings were performed on COX-2 steroids (15 and 16) and hypoxia-inducible factor 1 alpha for limonoids (3,6), with this target being essential for the intracellular development of leishmania. Limonoids 3 and 6 appear to be promising as leishmanicidal agents, and fatty acids are promising as wound healers.
Case Report: Leadless and left bundle branch area pacemakers, complementary advantages require a personalized approach
Authors: Yousuf Omair , Lee Jae (Jeff) , Atwater Brett D.
Published: July 2024

Traditional transvenous pacemakers consist of a pacemaker generator usually positioned surgically in the upper left chest on the pectoral muscle fascia and one or more leads positioned through the veins to the right atrium and across the tricuspid valve to the right ventricular apex. While these devices reduce symptoms and improve survival among patients with symptomatic bradycardia, they are associated with an increased risk of infection, venous occlusion, heart failure, and tricuspid valve regurgitation. Although new pacemaker designs minimize these risks, none of the current-generation pacemaker designs effectively eliminate all of them. A personalized approach to selecting the appropriate pacemaker for each patient is needed to optimize outcomes.
A novel affordable user interface for robotic surgery training: design, development and usability study
Authors: Neri Alberto , Coduri Mara , Penza Veronica , Santangelo Andrea , Oliveri Alessandra , Turco Enrico , Pizzirani Mattia , Trinceri Elisa , Soriero Domenico , Boero Federico , Ricci Serena , Mattos Leonardo S.
Published: July 2024

Introduction

The use of robotic systems in the surgical domain has become groundbreaking for patients and surgeons in the last decades. While the annual number of robotic surgical procedures continues to increase rapidly, it is essential to provide the surgeon with innovative training courses along with the standard specialization path. To this end, simulators play a fundamental role. Currently, the high cost of the leading VR simulators limits their accessibility to educational institutions. The challenge lies in balancing high-fidelity simulation with cost-effectiveness; however, few cost-effective options exist for robotic surgery training.

Methods

This paper proposes the design, development and user-centered usability study of an affordable user interface to control a surgical robot simulator. It consists of a cart equipped with two haptic interfaces, a VR visor and two pedals. The simulations were created using Unity, which offers versatility for expanding the simulator to more complex scenes. An intuitive teleoperation control of the simulated robotic instruments is achieved through a high-level control strategy.

Results and Discussion

Its affordability and resemblance to real surgeon consoles make it ideal for implementing robotic surgery training programs in medical schools, enhancing accessibility to a broader audience. This is demonstrated by the results of an usability study involving expert surgeons who use surgical robots regularly, expert surgeons without robotic surgery experience, and a control group. The results of the study, which was based on a traditional Peg-board exercise and Camera Control task, demonstrate the simulator’s high usability and intuitive control across diverse user groups, including those with limited experience. This offers evidence that this affordable system is a promising solution for expanding robotic surgery training.
Porosity–permeability characteristics and mineralization–alteration zones of the Maoping germanium-rich lead–zinc deposit in SW China
Authors: Wu Jianbiao , Han Runsheng , Zhang Yan , Wu Peng , Gong Hongsheng , Wang Lei , Cheng Gong , Li Xiaodong , Yang Yixuan , Mi Yaya
Published: July 2024

The Maoping superlarge germanium-rich lead–zinc deposit is a typical nonmagmatic hydrothermal deposit that is structurally controlled in the Sichuan–Yunnan–Guizhou lead–zinc polymetallic metallogenic area. The orebodies are distributed in several formations. This paper is based on large-scale alteration mapping combined with porosity and permeability measurements. We delineated the mineralization–alteration zones of different ore-bearing formations, explored the geological significance of porosity and permeability, and proposed prospecting directions. The research results indicate that during the mineralization period, the ore-forming metal fluids migrated from the deep part of the SSW region to the shallow part of the NNE region along the ore-guiding structure (Maoping Fault). Through the ore distribution structure, depressurization boiling occurred in the open space of the NE-trending interlayered sinistral compressive–torsional faults in several ore-bearing formations, resulting in fluid precipitation and the formation of different brecciated hot-melt dolomite lead–zinc mineralization zones. From the orebody to the wallrock, the C2w Formation and D3zg Formation are divided into four different mineralization–alteration zones. Tectonic activity affects the properties, migration, and precipitation of fluids, thereby controlling the alteration characteristics generated during fluid migration and thus changing the porosity and permeability. The porosity and permeability of strata on the NW flank of the anticline are greater than those of strata on the SE flank. On the NW flank, the greater the degree of mineralization–alteration is, the greater the porosity and permeability are, and the porosity of the orebody is lower than that during dolomitization. Finally, we believe that the NW flank of the anticline is an important area for prospecting. The pyrite + striped altered dolomite zone (Zones II–III) in the C2w limestone and the pyrite + strong dolomite zone (Zones II–III) in the D3zg dolomite are important prospecting indicators.
Developing ecological protection redline policy for land use pattern optimization in the typical black soil region of Northeastern China
Authors: Chen Yu , Zhao Xinyu , Wu Song , Tong Zhiqiang
Published: July 2024

Typical black soil regions in Northeastern China (TBSN) are facing problems of degradation of ecosystem services (ESs) and spatial conflicts between cropland and ecological land. Ecological Protection Redline (EPR) policy is one of the first national policies to utilizing multiple ESs. However, there is no standardized framework of delineation and validation for TBSN. In this study, the framework of Ecological Protection Redline delineation was further improved in three aspects of the ecosystem, namely, service function, ecological sensitivity, and biodiversity. Specifically, the framework considered the conflict between high-quality cropland and ecological land in the TBSN. We examined EPR effectiveness by comparing ESs and trade-off/synergistic relationships of different land use scenarios for 2035. The results show that 1) the EPR delineation threshold for each key indicator was determined to be 15%, considering the quality level of cropland. The ecological redline area of 89,593.63 km2 was identified, which was concentrated in the southwestern part of the Mengdong typical black soil subzone and Songnen typical black soil subzone. 2) Compared to the current ecological protection scenario and current ecological protection redline scenario, the optimized EPR scenario was the best solution to guarantee the sustainable development of the TBSN, maximizing ESs, weakening trade-offs, and strengthening synergistic relationships between them. The results of the study provided a theoretical basis for land use planning and the scientific management of ecosystems in the TBSN.
Novel de novo SPAST mutation in a Han Chinese SPG4 patient: a case report
Authors: Xu Yu-Han , Yuan Bao-Yu , Ji Jia-Le , Wu Di , Zhou Hong , Guo Yi-Jing
Published: July 2024

Spastic paraplegia type 4 (SPG4), the predominant form of Autosomal Dominant Hereditary spastic paraplegia (AD-HSP), is characterized by variants in the SPAST gene. This study reports a unique case of a late-onset SPG4 in a Han Chinese male, manifesting primarily as gait disturbances from lower extremity spasticity. Uncovered through whole-genome sequencing, a previously undocumented frameshift variant, c.1545dupA in exon 14 of the SPAST gene, was identified. Notably, this variant was absent in asymptomatic parents with confirmed paternity and maternity status, suggesting a de novo variant occurrence. This discovery emphasizes the potential of de novo variants to exhibit a late-onset pure pattern, extending the SPG4 variant spectrum, and consideration of such variants should be given in HSP patients with a negative family history.
Gendered (SDG5) and other perspectives on COVID-19 vaccination status: a focus on South Africa's Limpopo province
Authors: Nhamo Godwell , Maoela Malebajoa Anicia
Published: July 2024

One of the key issues embedded in the 2030 Agenda for Sustainable Development is the need for disaggregated data. Given the nature of the Coronavirus disease 2019 (COVID-19), studies on such should respond to this call. This paper investigates gendered and other perspectives on COVID-19 vaccination status in South Africa's Limpopo Province. The work utilises a household survey (n = 4,571), data from Our World in Data and Johns Hopkins University, as well as policy documents and academic literature. The findings are that the government moved away from a goal to attain 67% herd immunity, to the containment strategy. While the country attained 35% of population fully vaccinated, the current study reveals 72.84% of the respondents fully vaccinated in Limpopo (including those receiving a booster). Noteworthy findings include 7.1% of the respondents reporting partial vaccination and 19.8% expressing vaccine hesitancy. Gender differences were significant, with females exhibiting higher vaccination rates than males, and age-related variations were observed, particularly among the youngest participants. Further analysis stratified by gender and age groups unveiled substantial disparities, emphasizing the need for targeted interventions. Additionally, the study highlights patterns in COVID-19 vaccine uptake based on education levels, with higher education associating with increased vaccination rates. Significant gender-based differences in vaccine uptake across education levels indicate potential areas for focused public health efforts. The findings emphasise the complexity of factors influencing vaccination behaviour, providing valuable insights for policymakers, public health practitioners, and researchers aiming to enhance vaccine uptake and address disparities in diverse demographic groups.
A double-edged sword: unusual multiple severe infections with pralsetinib: a case report and literature review
Authors: Poumeaud François , Jaffrelot Marion , Gomez-Roca Carlos , Korakis Iphigénie , Leonardi Giulia , Joly Marine , Mazières Julien , Guimbaud Rosine , Fares Nadim , Alouani Emily
Published: July 2024

Selective rearranged during transfection (RET) tyrosine kinase inhibitor, pralsetinib, demonstrated clinical efficacy and was well tolerated in lung and thyroid cancers with RET gene mutations or fusions in clinical trials. While the latter focused on the risk of pneumonitis, there is a lack of data regarding other types of infectious risks associated with pralsetinib. Herein, we report the case of a 53-year-old patient with a CCDC6-RET fusion neuroendocrine tumor, who achieved a partial response with pralsetinib as the fifth-line therapy. Of particular note, during pralsetinib therapy, the clinical course was complicated by five severe infectious events, namely, two oxygen-requiring pneumonias, two distinct spondylodiscitis, and one pneumocystis. Our study highlights the increased risk of any type of opportunistic infectious event with pralsetinib, but not selpercatinib, which is probably caused by off-target JAK1/2 inhibition.
Influencing factors for pediatric eye disorders and health related quality of life: a cross-sectional study in Shanghai, China
Authors: Shu Qin , Xiao Zhongzhou , Peng Xinwei , Liang Xiaoyi , Chen Moxin , Tao Zhuoran , Liu Qianwen , Guo Yonglin , Yang Xuefeng , Nie Wanqin , Chen Ruiyao , Yang Liya , Li Jin , Xu Jie , Li Lin
Published: July 2024

Background

Myopia, strabismus, and ptosis are common pediatric eye diseases, which have a negative impact on children and adolescents in terms of visual function, mental health, and health-related quality of life (HRQoL). Therefore, this study focused on those pediatric eye diseases by analyzing their risk factors and HRQoL for the comprehensive management of myopia, strabismus, and ptosis.

Methods

A total of 363 participants (2–18 years old) were included in this study for risk factors analysis of myopia, strabismus, and ptosis. We collected demographic characteristics, lifestyle habits and eye care habits of these children and analyzed them by using univariable and multivariable logistic regression. In addition, we applied the Chinese version of Pediatric Quality of Life Inventory-Version 4.0 (PedsQL 4.0) to assess HRQoL in 256 children with strabismus and ptosis. Univariable and multivariable linear regression models were applied to evaluate potential influencing factors of HRQoL.

Results

Of all the participants, 140 had myopia, 127 had strabismus, and 145 had ptosis. Based on the multivariable logistic regression analysis model, we found that the history of parental myopia and daily average near-distance eye usage time were risk factors for myopia, and increased body mass index (BMI) was identified as a risk factor for strabismus and ptosis. Individuals with ptosis possessed decreased HRQoL. The multivariable linear regression model suggested that daily average near-distance eye usage time, light intensity during visual tasks, and daily average sleep duration had potential influences on HRQoL.

Conclusion

This is the first study to assess the risk factors and HRQoL of myopia, strabismus, and ptosis together. We identified risk factors for these common pediatric eye diseases to help doctors, parents, and teachers better manage them. Our study discovered that children with eye disorders exhibit a notably diminished HRQoL. Consequently, it emphasizes the necessity for increased social attention and mental health assistance for these children.
MetaBakery: a Singularity implementation of bioBakery tools as a skeleton application for efficient HPC deconvolution of microbiome metagenomic sequencing data to machine learning ready information
Authors: Murovec Boštjan , Deutsch Leon , Osredkar Damjan , Stres Blaž
Published: July 2024

In this study, we present MetaBakery (http://metabakery.fe.uni-lj.si), an integrated application designed as a framework for synergistically executing the bioBakery workflow and associated utilities. MetaBakery streamlines the processing of any number of paired or unpaired fastq files, or a mixture of both, with optional compression (gzip, zip, bzip2, xz, or mixed) within a single run. MetaBakery uses programs such as KneadData (https://github.com/bioBakery/kneaddata), MetaPhlAn, HUMAnN and StrainPhlAn as well as integrated utilities and extends the original functionality of bioBakery. In particular, it includes MelonnPan for the prediction of metabolites and Mothur for calculation of microbial alpha diversity. Written in Python 3 and C++ the whole pipeline was encapsulated as Singularity container for efficient execution on various computing infrastructures, including large High-Performance Computing clusters. MetaBakery facilitates crash recovery, efficient re-execution upon parameter changes, and processing of large data sets through subset handling and is offered in three editions with bioBakery ingredients versions 4, 3 and 2 as versatile, transparent and well documented within the MetaBakery Users’ Manual (http://metabakery.fe.uni-lj.si/metabakery_manual.pdf). It provides automatic handling of command line parameters, file formats and comprehensive hierarchical storage of output to simplify navigation and debugging. MetaBakery filters out potential human contamination and excludes samples with low read counts. It calculates estimates of alpha diversity and represents a comprehensive and augmented re-implementation of the bioBakery workflow. The robustness and flexibility of the system enables efficient exploration of changing parameters and input datasets, increasing its utility for microbiome analysis. Furthermore, we have shown that the MetaBakery tool can be used in modern biostatistical and machine learning approaches including large-scale microbiome studies.
Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients
Authors: Lin Ya-ling , Wang Chia-Liang , Chiang Tsay-I
Published: July 2024

Background

The objective of this study is to investigate the effects of oral supplementation with eicosapentaenoic acid (EPA) on circulating inflammatory factors, cardiometabolic parameters, skin moisturization, and the consequent symptoms of pruritus and depression in maintenance hemodialysis patients.

Materials and methods

A total of 60 maintenance hemodialysis patients with severe pruritus symptoms completed this randomized, placebo-controlled study. Subjects of treatment group (n = 30) were instructed to consume 1000 mg fish oil (>900 mg EPA) and subjects of placebo group (n = 30) were instructed to consume 1000 mg soybean oil twice daily for 3 months. 5-D pruritus scoring, the Beck Depression Inventory (BDI) scale, skin moisture, serum creatinine, inflammatory factors, and cardiometabolic parameters were examined at baseline, and at the first, second, and third month post-supplementation.

Results

A significantly decreased pruritus level was observed in the treatment group, whereas an opposite result was observed in the placebo group. Increased skin moisture levels on both the face and arms were observed in the treatment group, but not in the placebo group. Supplementation of EPA significantly decreased serum CRP and IL-6 levels. Significant decreases in total cholesterol (CHO), and triglycerides (TG) levels were observed; however, a decrease in high-density lipoprotein (HDL) level was observed in the treatment group. There was no change in plasma creatinine (CR) observed in both groups. A significantly decreased BDI score was observed, whereas the opposite result was observed in the placebo group. A correlational study showed that the severity of pruritus was significantly associated with skin moisture and serum CRP. The severity of pruritus was also positively correlated with the BDI score.

Conclusion

Supplementation of EPA may provide multiple benefits including alleviating pruritus symptoms, addressing skin dryness, and mitigating depression in maintenance hemodialysis patients.
Dietary supplementation with mulberry leaf flavonoids and carnosic acid complex enhances the growth performance and antioxidant capacity via regulating the p38 MAPK/Nrf2 pathway
Authors: Liu Chunming , Huang Hui , Chen Yulian , Zhou Yingjun , Meng Tiantian , Tan Bihui , He Wenxiang , Fu Xiaoqin , Xiao Dingfu
Published: July 2024

Introduction

This study aimed to investigate the regulatory effects of mulberry leaf flavonoids and carnosic acid complex (MCC) on the growth performance, intestinal morphology, antioxidant, and p38 MAPK/Nrf2 pathway in broilers.

Methods

A total of 256 healthy 8-day-old female yellow-feathered broilers were randomly divided into 4 equal groups: a control group (CON) fed a basal diet, an antibiotic group (CTC) supplemented with 50 mg/kg chlortetracycline, and two experimental groups (MCC75, MCC150) fed basal diets with 75 mg/kg and 150 mg/kg of MCC, respectively. The experiment lasted for 56 days, with days 1–28 designated as the initial phase and days 29–56 as the growth phase.

Results

The results on the growth performance showed that diets supplemented with MCC and CTC decreased the feed-to-gain ratio (F/G), diarrhea rate, and death rate, while significantly increasing the average daily weight gain (ADG) (p < 0.05). Specifically, the MCC150 group enhanced intestinal health, indicated by reduced crypt depth and increased villus height-to-crypt depth ratio (V/C) as well as amylase activity in the jejunum. Both the MCC and CTC groups exhibited increased villus height and V/C ratio in the ileal (p < 0.05). Additionally, all treated groups showed elevated serum total antioxidant capacity (T-AOC), and significant increases in catalase (CAT) and glutathione peroxidase (GSH-Px) activities were observed in both the MCC150 and CTC groups. Molecular analysis revealed an upregulation of the jejunal mRNA expression levels of PGC-1α, Nrf2, and Keap1 in the MCC and CTC groups, as well as an upregulation of ileum mRNA expression levels of P38, PGC-1α, Nrf2, and Keap1 in the MCC150 group, suggesting activation of the p38-MAPK/Nrf2 pathway.

Discussion

These findings indicate that dietary supplementation with MCC, particularly at a dosage of 150 mg/kg, may serve as a viable antibiotic alternative, enhancing growth performance, intestinal health, and antioxidant capacity in broilers by regulating the p38-MAPK/Nrf2 pathway.
A case report and literature review on TP53 gene mutation in a bladder rhabdomyosarcoma patient
Authors: Li Yixuan , Yang Tianci , Zheng Zhouhang , Wang Zhong , Umar Shahzard Muhammad , Fan Ning , He Shenbao , Chang Wei , Wang Wei
Published: July 2024

Background

Rhabdomyosarcoma of the bladder is an infrequent neoplastic condition characterized by a pronounced malignant situation with challenges in treatment due to the lack of standardized guidelines and large-scale of clinical studies. The patient in this case is tested TP53 mutation that may provide new diagnostic and therapeutic options.

Case presentation

Here, we reported a 34-year-old male who received bladder tumor resection, and diagnosed as bladder rhabdomyosarcoma with TP53 mutation after the pathology test. This patient underwent 6 rounds of chemotherapy. However, the pelvic tumor recurred 11 months after the first surgery. So, the patient accepted the pelvic tumor resection. Only 3 months after the surgical intervention, the patient underwent abdominal massive metastasis and ultimately succumbed to the illness six months following the second surgery. The course of the illness was 22 months.

Conclusion

Bladder rhabdomyosarcoma is a disease with an extremely poor prognosis. Genetic testing holds significant value in the diagnosis and treatment. Perhaps targeted therapy against TP53 is potential valuable for such rare diseases.
Nanoparticles (NPs)-mediated lncMALAT1 silencing to reverse cisplatin resistance for effective hepatocellular carcinoma therapy
Authors: Wang Ting , Li Qianyao , Xu Rui , Zhao Zixuan , Sun Qi , Xu Xiaoding , Li Rong
Published: July 2024

Platinum-based chemotherapy has been widely used for clinical cancer treatment, but drug resistance is the main barrier to induce the poor prognosis of cancer patients. Long non-coding RNAs (lncRNAs) have been recognized as a type of new cancer therapeutic targets due to their important role in regulating cancer progression such as drug resistance. However, it is still challenged to effectively intervene the expression of lncRNAs as they are usually located at various subcellular organelles (e.g., nucleus, mitochondrion, and endoplasmic reticulum). We herein developed an endosomal pH-responsive nanoparticle (NP) platform for small interfering RNA (siRNA) and cisplatin prodrug co-delivery and effective cisplatin-resistant hepatocellular carcinoma (HCC) therapy. This co-delivery nanoplatform is comprised of a hydrophilic polyethylene glycol (PEG) shell and a hydrophobic poly (2-(diisopropylamino)ethyl methacrylate) (PDPA) core, in which cisplatin prodrug and electrostatic complexes of nucleus-targeting amphiphilic peptide (NTPA) and siRNA are encapsulated. After intravenous injection and then uptake by tumor cells, the endosomal pH could trigger the dissociation of nanoplatform and enhance the endosomal escape of loaded cisplatin prodrug and NTPA/siRNA complexes via the “proton sponge” effect. Subsequently, the NTPA/siRNA complexes could specifically transport siRNA into the nucleus and efficiently reverse cisplatin resistance via silencing the expression of lncRNA metastasis-associated lung adenocarcinoma transcript 1 (lncMALAT1) mainly localized in the nucleus, ultimately inhibiting the growth of cisplatin-resistant HCC tumor.