bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship between menarche age and parity with the incidence of uterine myomas
Authors: Indryani Indryani , Mustar Mustar , Ali Sarina , Susilawati Susilawati , Ismawati Ismawati
Published: November 2024

Background: Uterine myomas, or fibroids, are one of the most common benign tumors that occur in women of reproductive age, with a reasonably high prevalence worldwide. However, rarely, potentially malignant uterine myomas can cause a variety of health problems, including excessive menstruation, pelvic pain, fertility disorders, and pregnancy complications.
Objective: This study aims to analyze the relationship between menarche age and parity with the incidence of uterine myoma.
Methods: Types and design of research the plan used in this exploration is quantitative exploration with a case control approach. Sampel berjumlah 138 responden masing-masing 102 ibu yang mengalami mioma uteri dan 36 ibu yang tidak mengalami efek buruk mioma uteri.
Results: The test results measured using the chi-square test were obtained with p-value menarche age = 0.004 and parity p-value = 0.000, meaning that there was a very large relationship between menarche age and parity with the incidence of uterine myomas.
Conclusion: It can be concluded that the earlier the age of menarche increases the risk of uterine myoma later in life. In contrast, slower menarche may be associated with a reduced risk of myomas. Other factors such as genetic, environmental, and lifestyle factors also influence the incidence of uterine myomas, but menarche age is one of the significant hormonal indicators of risk
Video media is more effective to improve balanced nutrition knowledge
Authors: Asmi A. Syamsinar , Tyarini Indrawati Aris , Saputra M. Khalid Fredy , Putra Jaimin Adi , Son Hae Kyoung
Published: November 2024

Introduction: Providing appropriate nutrition information is important to increase public knowledge about balanced nutrition. One proven effective method is using video media as a means of education.
Objective: Analyze the effectiveness of video media in increasing knowledge about balanced nutrition.
Methods: This study uses a quasi-experimental study design without group controls. The population of this study is all students, with a sample of 52 people who meet the inclusion and exclusion criteria. The sampling technique used stratified random sampling.
Result: The study showed that the use of video increased the average knowledge score (mean) by 85.96 video (p=0.003). This study shows that providing nutrition education with video media is more effective in increasing balanced nutrition knowledge.
Conclusion: Video media has been proven more effective in increasing knowledge about balanced nutrition. Video media can present information more interesting, interactive, and visually, making it easier for the audience to understand and remember the material conveyed. A significant increase in knowledge in the group receiving the video media intervention showed that this method is an effective educational tool in balanced nutrition campaigns. Therefore, video media is recommended as a nutrition counseling strategy to expand the reach and impact of health education in the community.
Decoction of bay leaf (syzygium polyanthum) against the reduction of high blood pressure in 3-month injectable birth control receptors
Authors: S Irmawati , Rosdianah Rosdianah , Wahyuningsih Tia Yulita , Yunus Muh
Published: November 2024

Introduction: Hypertension or high blood pressure is a serious health problem and has the potential to trigger various complications, such as heart disease and stroke. Bay leaf (Syzygium polyanthum), which is traditionally used as an herbal medicine, is known to contain bioactive compounds such as flavonoids, tannins, and saponins, which have the potential to lower blood pressure. However, research on the effectiveness of bay leaf decoction in 3-month injectable birth control receptors is still limited.
Objective: This study aims to evaluate the effect of bay leaf decoction (Syzygium polyanthum) on the reduction of high blood pressure in 3-month injectable birth control receptors.
Methods: This study uses a quasi-experimental method with a pre-test and post-test design in one group. A total of 60 respondents who were long-term acceptors of 3-month injectable birth control with high blood pressure were selected purposively. The respondents were given a decoction of bay leaves every day. Blood pressure was measured before and after the intervention using a digital sphygmomanometer. Data were analyzed using a paired t-test to determine the significant difference between blood pressure before and after the intervention.
Result: The study showed a significant decrease in systolic and diastolic blood pressure after administering bay leaf decoction. The average decrease in systolic blood pressure was 12 mmHg, and diastolic blood pressure was eight mmHg after 14 days of consumption. The paired t-test showed a p< value of 0.05, indicating a significant difference between blood pressure before and after the intervention.
Conclusion: Bay leaf decoction (Syzygium polyanthum) significantly lowers high blood pressure in 3-month injectable birth control receptors. These results suggest that bay leaf can be a potential complementary therapy in the management of hypertension, especially for those who use long-term hormonal contraceptives. Although the results of this study are promising, more research with larger sample sizes and extended intervention periods is needed to confirm these findings and assess the long-term safety of using bay leaf decoction
Analysis of factors related to the incidence of hypertension in the elderly
Authors: Mbali Menis , Herman Sriyana , Rahman Abdul
Published: November 2024

Introduction: Hypertension or high blood pressure is one of the main health problems in the elderly population in various parts of the world. The elderly are more susceptible to hypertension due to the ageing process that affects the elasticity of blood vessels, as well as increased peripheral resistance. In addition, various risk factors, such as an unhealthy lifestyle, poor diet, and certain medical conditions, can worsen the condition of hypertension in the elderly.
Objective: This study aims to analyze factors related to the incidence of hypertension in the elderly.
Methods: This research uses a cross-sectional design, an analytical study that studies the causes of incidents or incidents. Data collection uses a questionnaire. The sample in this study was 64 elderly hypertensive patients in the working—data analysis using the chi-square test.
Result: The results of this study indicate that there is a relationship between physical activity (p=0.000), obesity (p=0.000), diet (p= 0.029), smoking habits (p=0.000) and work (p=0.020) with the incidence of hypertension in the elderly in working.
Conclusion: The incidence of hypertension in the elderly with the variables studied shows that there is a relationship, and the most related variable is obesity. So, it is hoped that the elderly, especially those who are obese, should be given intervention to maintain their diet so that complications do not occur and can reduce the risk of hypertension.
Analysis of determinant factors affecting treatment compliance of hypertensive patients
Authors: Fauziani Iva , Ramli Anwar , Fitrianingsih Julia
Published: November 2024

Introduction: Hypertension requires regular and controlled treatment to stabilize blood pressure and prevent complications. Many hypertensive patients do not comply with hypertension treatment procedures, including medication.
Objective: This study aimed to analyze the determinant factors influencing medication compliance in hypertensive patients.
Methods: The research method used was observational analytic with a cross-sectional design. Data collection using a questionnaire. The sample in this study was 67 hypertension patients. Data analysis used the chi-square test.
Result: The results of this study indicate that there is an influence of the level of knowledge (p = 0.045), motivation to seek treatment (p = 0.000), and family support (p = 0.000) on medication compliance in hypertensive patients.
Conclusion: Motivation to seek treatment is the most dominant variable on compliance with the treatment of hypertension patients. Health workers must develop an educational strategy focusing on increasing patient motivation.
The Relationship between nutritional status and menstrual cycle and anemia
Authors: Wijayanti Lumastari Ajeng , Nurseskasatmata Satria Eureka
Published: November 2024

Introduction: Adolescence is a period of growth and puberty; adolescents are very concerned about appearance, so they pay attention to their diet until they are strict. This causes the intake needed to be unmet, then impacts the menstrual cycle and anemia.
Objective: This study aims to analyze the relationship between nutritional status, the menstrual cycle, and the incidence of anemia in adolescent girls.
Method: This research is an analytic observational study. The approach in this research is cross-sectional. The population is 447 female students aged 13-15; the sample is 83. Sampling using consecutive sampling. The data collection instrument used a questionnaire to determine the menstrual cycle, measure height and weight, and measure Hb levels with digital tools.
Results: This study uses the Spearman Rank test formula value 0.05. The results of nutritional status with menstrual cycles were 0.016 < 0.05, and then significant results were obtained; on nutritional status with anemia, the results were 0.00 < 0.05, then substantial results were obtained, and the results of menstrual cycles with anemia were 0.06 > 0.05 then the result is not essential.
Conclusion: It can be concluded that there is a relationship between nutritional status and the menstrual cycle and anaemia, but there is no relationship between the menstrual cycle and anaemia. Optimal nutritional status, including adequate iron intake, is essential for maintaining menstrual health and preventing anemia. Nutrition interventions and health education on the importance of balanced nutrition can be a practical step in supporting women's reproductive health
The effectiveness of reproductive midwifery care with the flour albus approach: A Case Study of handling vaginal discharge in women of childbearing age
Authors: Marbun Uliarta , Sari Nur Safitri , Irnawati Irnawati , Sari Lili Purnama , Dahniar Dahniar
Published: November 2024

Introduction: Women of childbearing age have a higher risk of vaginal discharge than adolescents because of the frequent occurrence of pelvic inflammatory disease (PID). One of the symptoms of reproductive organ infections in women is vaginal discharge.
Objective: This study aims to apply midwifery care to cases of vaginal discharge (flour albus).
Methods: A descriptive method with a case study approach is used. Data was collected through primary data, including assessment and observation of the patient's health status, interviews to obtain subjective data, and direct examination for objective data. Secondary data was obtained through patient records, registered books in the KIA room, and literature studies.
Result: The results showed that the symptoms of vaginal discharge in patients included thick white mucus, unpleasant odor, and itching in the genital area. The care provided uses red betel leaf water decoction as a treatment effort. After obstetric care was carried out from July 16 to 20, 2024, the results were obtained that the patient's vaginal discharge improved without signs of genetic infection.
Conclusion: The success of this care is also marked by an increase in patients' understanding of good personal hygiene, how to properly clean the feminine area from front to back, and the effective use of red betel leaf boiled water. Thus, the management of obstetric care applied to this case of vaginal discharge is quite successful and practical, with a decoction of red betel leaves providing a positive effect in reducing the incidence of pathological vaginal discharge.
The physical quality test formulation of ethyl acetate extract of kawista fruit peel (Limonia Acidissima L.) Ointment as an antibacterial against propionibacterium acnes
Authors: Megawati Megawati , Kadang Yuniharce
Published: November 2024

Introduction: Using medicinal plants in Indonesia still needs to be optimized. Almost all parts of the Kawista plant have been traditionally used to treat various ailments such as antioxidants, antidiabetic, wound healing, and controlling uric acid levels. Existing research on Kawista fruit peel as an acne antibacterial includes studies on the ethyl acetate extract of Kawista fruit peel against Propionibacterium acnes, which falls into the moderate to strong category. In Indonesia, Kawista fruit is limited to the flesh and is used to make syrup and dodol (a traditional sweet). In contrast, the fruit's peel remains a waste product.
Objective: This study aims to develop a formula for an ethyl acetate extract ointment of Kawista fruit peel (Limonia acidissima L.) as an antibacterial agent against Propionibacterium acnes with good physical quality.
Methods: The fruit peel extract was obtained using the maceration method with 96% ethanol. The extract was then formulated into ointment preparations with concentration variations of 6.25% (F1), 12.50% (F2), and 25% (F3). The physical stability tests for the ointment included organoleptic parameters, homogeneity, spreadability, and pH value tests. The data were analyzed to determine the effect of the extract concentration and storage time on the ointment's physical stability.
Result: The test results showed that the ointment formulation of Kawista fruit peel extract (Limonia acidissima L.) could be successfully formulated into an ointment form and met the required evaluation criteria, including organoleptic testing, homogeneity testing, pH testing, and spreadability testing.
Conclusion: Based on the study, it can be concluded that the Kawista fruit peel extract ointment (Limonia acidissima L.) can be successfully formulated into an ointment and meets the required evaluation criteria, including organoleptic testing, homogeneity testing, pH testing, and spreadability testing. A skin irritation test is required to determine whether any irritation occurs after applying the ointment.
Pengaruh Evaluasi Kinerja dan Motivasi Kerja Guru Terhadap Mutu Pendidikan di SMA Negeri 1 Bawolato
Authors: Telaumbanua Devid Juli Yanti , Halawa Odaligoziduhu , Baene Eduar , Lase Delipiter
Published: November 2024

This study aims to analyze the impact of teacher performance evaluation and work motivation on the quality of education at SMA Negeri 1 Bawolato. The research employs a quantitative method with a multiple linear regression approach. The sample consists of 39 respondents, namely teachers at SMA Negeri 1 Bawolato. Data were collected through validated and reliable questionnaires and processed using SPSS version 26. The results indicate that both performance evaluation (X1) and teacher work motivation (X2) partially have a significant impact on the quality of education (Y). Partial regression tests yielded a t-value of 2.302 for the performance evaluation variable with a significance of 0.027, and a t-value of 2.959 for work motivation with a significance of 0.058. Additionally, both variables simultaneously showed a significant influence on education quality, with an F-value of 26.192, greater than the F table value (3.25), and a significance of 0.000. The determination coefficient (R Square) of 0.593 indicates that 59.3% of the variance in education quality is influenced by performance evaluation and work motivation, while the remaining 40.7% is influenced by other unexamined factors. This suggests that improving teacher performance evaluation and work motivation significantly contributes to enhancing the quality of education at SMA Negeri 1 Bawolato. The study concludes that teacher performance evaluation and work motivation are crucial factors in improving education quality. Therefore, schools are advised to continuously develop effective performance evaluation mechanisms and strategies to enhance teacher motivation to achieve better educational quality.
Efektivitas Gaya Kepemimpinan dalam Menciptakan Lingkungan Kerja
Authors: Dawolo Jelita , Waruwu Meiman Hidayat , Lase Delipiter , Eliagus Telaumbanua
Published: November 2024

This study aims to analyze the leadership style implemented at CV Golden Mart Gunungsitoli, examine employee perceptions of this style, and identify the barriers in its application. A qualitative descriptive method was employed, involving key informants with firsthand experience regarding the company’s leadership approach. Findings indicate that leadership at CV Golden Mart tends to be centralized and control-oriented, leading to a generally negative perception among employees. Employees feel inadequately involved in decision-making processes, which negatively affects their motivation and productivity. It is recommended that company leaders adopt a more inclusive leadership approach by engaging employees in decision-making. Implementing participative leadership principles is expected to enhance employee engagement, motivation, and job satisfaction.
Efektivitas Pemberian Jaminan Sosial kepada Pegawai
Authors: Waruwu Wita Yarni , Meiman Hidayat Waruwu  , Zega Yamolala , Hulu Fatolosa
Published: November 2024

Social security plays an essential role in human resource (HR) management, particularly in improving employee welfare, as employees are key assets in any organization. This study aims to analyze the effectiveness of implementing the social security program at PT. Bank Sumut KCP Lahewa, North Nias Regency, and its impact on employees. A qualitative method was used, with interviews conducted to gain employees' views on the program's benefits. The results show that the program has been implemented effectively. Employees feel their well-being is supported through two health insurance options, Mandiri Inhealth and BPJS, which offer sufficient protection. This program enhances employees' sense of security and comfort, positively influencing their motivation and productivity. However, there are technical issues in the claims process that require further assessment. The study recommends that the company improve social security outreach, streamline the claims process, and consider additional relevant coverage options. Thus, social security is expected to further support employee welfare and foster a more productive work environment.
The Influence of Intellectual Capital, GCG, and ROA on Bank Performance
Authors: Suseno  , Nissa Fachrun , Yaqin Nurul , Budiastuti Susanti , Guntoro
Published: November 2024

The purpose of this study is to analyze the influence of Intellectual Capital, Good Corporate Governance (GCG), and Capital Adequacy Ratio (CAR) on financial performance. This research adopts a quantitative approach with panel data regression analysis. The theoretical foundation is established through a review of relevant literature from journal articles and books. The study utilizes numerical data derived from secondary sources, specifically financial reports obtained through the official website of the Indonesia Stock Exchange (IDX). The study population comprises Islamic commercial banks listed on the IDX from 2017 to 2022. Using a purposive sampling technique, 54 samples from 9 Islamic commercial banks were selected. Data analysis was conducted using EViews 10 software, applying the Random Effect Model (REM). The findings reveal that Intellectual Capital, GCG, and CAR significantly impact the financial performance of Islamic commercial banks listed on the IDX between 2017 and 2022. This study provides valuable insights into the financial health of banks, categorized into safe, gray, or distressed zones, thereby offering practical implications for Islamic commercial banks.
A RARE ANOMALY OF AORTIC VALVE
Authors: Ponnaganti Vasundhara , Vengatesh M
Published: November 2024

Background: The Quadricuspid aortic valve (QAV) is a rare; often isolated, sometimes associated with
other heart diseases. We report a case of quadricuspid aortic valve. 46 yr old Female who Case Report:
came to our OPD with complaints of breathlessness, palpitations past 2 months. On further evaluation echo showed
quadricuspid aortic valve , severe Aortic regurgitation. Patient was referred for surgery. The quadr Conclusion: icuspid aortic
valve is one cause of signicant aortic regurgitation that is the predominant clinical nding. It's early recognition is particularly
important for surgical management.
APPLICATION OF FREE ENERGY WATER-PUMP FOR CLEAN CROP PRODUCTION THROUGH NFT-HYDROPONIC SYSTEM IN RESPONSE TO CLIMATE CHANGE
Authors: Keokhamphui Keoduangchai , Keovongsa Iep , Xaipanya Phetyasone , Inthavong Thinphia , Pakdimanivong Mary
Published: November 2024

Water-based cropping is a technology that has long been used abroad but is rarely used in Lao PDR due to its high cost. several scholars type to nd
the solution for reducing the cost of growing vegetables and mitigating soil degradation. As this experiment efforted in optimization of water
supply for the growing system to avoid using of energy in driving water but it was unsuccessful. However, the purpose of this experiment was to 1)
create a calendar of market demand for vegetables to create a planting plan; 2) determine the suitability of air temperature, humidity, including pH,
and EC values of water in the growing system; 3) Control the concentration of nutrients that plants need at each stage of growth. Sellers' interviews,
climate monitoring, and recording, monitoring and measuring plant growth, and water quality measurement and analysis were the methods used in
this experiment.
PREDICTORS OF GRAFT REJECTION FOLLOWING FULL THICKNESS PENETRATING KERATOPLASTY - A PROSPECTIVE ,ANALYTICAL HOSPITAL BASED STUDY
Authors: Niranjana K. , Dinesh Radhika
Published: November 2024

This study analysed the inuence of various risk factors on graft rejection and emphasized the
importance of its early recognition and management. Materials & Methods: Prospective, Analytical,
Hospital-based study, the study population consisted of 84 eyes of 80 patients who underwent full-thickness penetrating
keratoplasty from September 2014 to May 2016. All transplant surgeries were performed by a single surgeon. Patients were
examined on the rst postoperative day and followed up periodically. During each visit, the graft was assessed and ndings
documented. Results: Rejection rate was 34.52% (29 out of 84 eyes). Young recipient age, presence of corneal vascularisation
and peripheral anterior synechiae were associated with a signicantly higher risk of rejection. Conclusion: Identication of high
risk patients preoperatively helps the surgeon to plan for aggressive therapy and follow up of these patients.
PERCEPTION, KNOWLEDGE, AND UTILIZATION OF INTERDENTALAIDS AMONG PATIENTS AT A GOVERNMENT DENTAL COLLEGE AND HOSPITAL IN AHMEDABAD: A CROSS-SECTIONALANALYSIS
Authors: Parmar Tamanna , Tehri Vinamrata , A. Brahmbhatt Nilam
Published: November 2024

Background: Oral health is integral to overall health, with the oral cavity serving as a reection of general well-being. Effective oral hygiene
practices, including the use of interdental aids, play a crucial role in maintaining oral health. This study aimed to assess the perception and usage of
interdental aids among patients at Government Dental College and Hospital, Ahmedabad. Methods: A cross-sectional questionnaire-based study
was conducted involving 500 participants. Data collection utilized structured questionnaires in English and Gujarati, assessing oral hygiene
practices, awareness of interdental aids, and demographic information. Statistical analysis was performed using Microsoft Excel, with signicance
set at p < 0.05. Results: The majority (75%) of participants used toothbrushes and toothpaste for oral hygiene, with only 34% employing
interdental aids. Awareness of interdental aids was found to be higher among patients undergoing treatment (80%) compared to those in the
outpatient department (68%). Educational level signicantly inuenced awareness, with higher percentages among participants with a bachelor's
degree or higher (70%). Conclusion: The study highlights inadequate awareness and usage of interdental aids among patients at Government
Dental College and Hospital, Ahmedabad. Patients receiving treatment demonstrated better awareness, underscoring the role of healthcare
providers in promoting oral hygiene education. These ndings emphasize the need for targeted educational interventions to improve oral health
practices, particularly regarding interdental aid usage.
CELL BLOCK OVER TRADITIONAL SMEARS IN PLEURAL FLUID CYTOLOGY- A 3 YEARS STUDY IN A TERTIARY CARE CENTRE.
Authors: T. C. S Vidhya. , Kamakeri N S , Bhaskaran Amaya
Published: November 2024

Introduction: Pleural fluid cytology helps in staging and prognosis of malignant lesions. Recognizing whether cells in serous effusions are
malignant or reactive mesothelial cells could pose a diagnostic problem in conventional smears. Materials And Methods: A cross-sectional study
was conducted out between June 2020 and June 2023 . 260 pleural fluid samples were obtained for the purpose of research using both smear and
cell-block techniques. Based on the microscopic features all the pleural fluids has been classified as Benign, Suspicious of malignancy or positive
for malignancy in both smear and cell block. In conventional smear(CS), 237 patients had a benign eff Results: usion, 6 had a suspected
malignancy, and 17 had a positive result for malignancy. There were 235 cases of benign effusion, 2 cases of suspected malignancy, and 23 cases of
malignant effusion in cell block. In the present study diagnostic yield of malignant pleural effusion Discussion: in cell block (8.85%) is more than
that in conventional smears(6.54%). Hence the diagnostic yield of malignant effusion in cell block method is more when compared to smears.
Immunocytochemistry with BerEp4 and calretinin helps if malignant mesothelioma is suspected. The stu Conclusion: dy recommends using both
smears and cell blocks in parallel to increase diagnostic accuracy.Also cell Block improves the diagnostic potential when paired with IHC in
situations of suspected malignant mesothelioma.
THYROGLOBULIN ELEVATION AND NEGATIVE IODINE SCINTIGRAPHY (TENIS) SYNDROME: DIAGNOSTIC CHALLENGES, TREATMENT, AND NURSING IMPLICATIONS
Authors: P Bindhu.
Published: November 2024

Thyroglobulin Elevation and Negative Iodine Scintigraphy (TENIS) syndrome presents a unique diagnostic and therapeutic challenge in the
management of differentiated thyroid cancer (DTC) patients. Thyroglobulin (Tg) is a tumor marker produced by thyroid follicular cells, and its
elevated levels in the blood are often used to monitor disease recurrence or metastasis in patients who have undergone total thyroidectomy and
radioactive iodine therapy. In TENIS syndrome, patients exhibit persistently elevated serum thyroglobulin levels but have negative iodine-131
whole-body scintigraphy scans. This condition complicates the management of DTC, as iodine scintigraphy, which is typically used to detect
recurrent disease, becomes ineffective. This paper explores the diagnostic challenges, treatment strategies, and the nursing implications associated
with TENIS syndrome, with the goal of improving patient outcomes through comprehensive care.
SERRATUS ANTERIOR MUSCLE AS A SITE FOR MYOCYSTICERCOSIS: A RARE CASE ENCOUNTER
Authors: Chougule Somesh , Kumar G. Sai Sanjeev , Borkar Swinal
Published: November 2024

Cysticercosis is caused by the larval form of the pork tapeworm, Taenia solium. The central nervous system is commonly involved in this disease,
but it may affect the eyes, subcutaneous tissues, liver, gastrointestinal system, skeletal muscle, and at times lung and heart [1]. Although muscular
involvement is not that uncommon isolated involvement of serratus anterior muscle is a rare and unusual presentation.
DIAGNOSTIC UTILITY OF MAGNETIC RESONANCE IMAGING IN SERONEGATIVE SPONDYLOARTHROPATHIES: A RADIOLOGICAL PERSPECTIVE
Authors: Jain Vritika , Vani Kavita
Published: November 2024

The sero-negative spondyloarthropathies (SpA) comprise a group
of interrelated inammatory arthritides sharing common features.
This group comprises disease entities like ankylosing spondylitis,
reactive arthritis, psoriatic arthritis, arthritis associated with
chronic inammatory bowel disease (Crohn's disease and
ulcerative colitis), and undifferentiated spondyloarthropathies.
A STUDY ON OPHTHALMIC MANIFESTATIONS IN PITUITARY GLAND TUMOURS
Authors: Agrawal Harsh , S. Hora M. , Golash Rajesh , Singh Vivek , Pradhan Anushree , Arya Abhishek , Hemwani Kirti , Ramchandani Abhiraj
Published: November 2024

Background: A pituitary adenoma is a benign tumour of the adenohypophyseal cells of the anterior lobe of the pituitary gland. It accounts for 12%
to 15% of all intracranial tumours. A spectrum of ocular manifestations are seen with these tumours ranging from the absence of any visual
symptoms to severe visual field defects and loss of vision. The study aims to study the various ocular features and their effect on vision, visual fields
and ocular motility in cases of pituitary adenoma diagnosed on CT or MRI. This is a prospective stud Materials And Methods: y for a period of 1
year and 8 months conducted in the Ophthalmology department, Amaltas Institute Of Medical Science. 25 patients aged between 25 to 65 years
diagnosed with pituitary adenomas on radiological imaging, were evaluated after detailed history with visual acuity, pupillary reaction, colour
vision, extraocular movements, slit lamp and fundus examination. Visual field examination was done with an Octopus field analyser. Results: Out
of the 25 patients diagnosed with pituitary adenoma on radio imaging ,it was found that most patients were above 50 years. 15 patients were above
50 yrs i.e.60%. Females were predominantly affected (76%). Visual acuity of 62%of patients was between 6/12 and 6/6 . Headache was the most
common mode of presentation amounting to 80% of the total study sample. 76% showed field defects of which bitemporal hemianopia was the
commonest in 52.9%. Pituitary macroadenoma was the most common type as it was seen in 96% patients. Optic atrophy was seen only in 4 cases.
Others had normal fundus. : Neuro-ophthalmics is of utmost importance as it only helps in early det Conclusion ection, planning of treatment and
further follow up, but also prevents visual loss if intervened timely.
A CASE REPORT ON ILEAL GASTROINTESTINAL STROMAL TUMOR
Authors: Gudipati Pradeep , Chandana Adda Hari , Chakravarthi Rayani Mahesh , Chakravarthy Gogineni Raghuveer
Published: November 2024

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, though they account for only 1-
2% of all GI malignancies. They arise from interstitial cells of Cajal. Clinical presentations are diverse and depend on tumor size and location. This
case report highlights the rarity of ileal GIST and diagnostic confusion between adnexal and intestinal pathology.
LYMPHOID PAPILLARY HYPERPLASIA OF PALATINE TONSIL: A CASE REPORT
Authors: Thukral Vibhuti , Kumar Akhil , Dalakoti Swarnim , Rathee Pooja , Jain Shubham , Singh Sunita
Published: November 2024

Introduction: Lymphoid papillary hyperplasia(LPH) is a benign rare disorder of tonsils. It has been described mostly in the Japanese population.
Tonsils become hypertrophied in certain circumstances resulting in lymphoid hyperplasia and present as a papillomatous lesion. Usually, it is seen
in females, mostly involving bilateral tonsils. Our case presents with a unilateral (right-sided) papillomatous tonsillar mass. A Case Presentation:
fteen years old male patient presented in the Surgery OPD with 6 months history of foreign body sensation in the throat. On examination, a
papillomatous lesion was seen in the right tonsillar fossa. The patient was operated and resected mass was received in the department of Pathology,
which was further processed. Histopathological examination showed polypoid projections lined by hype Findings: rplastic squamous epithelium
with underlying lymphoid tissue showing predominant follicular hyperplasia consistent with the diagnosis of lymphoid papillary hyperplasia.
Conclusion: Since the features like female predominance and bilateral involvement of tonsils are typical presentations. Our case is a rare
presentation as we report right-sided LPH in a young male.
COVID-19 & INFLAMMATORY MARKERS IN TERTIARY CARE HOSPITAL.
Authors: Khajuria Anish , Chrungoo Vir Jee
Published: November 2024

The COVID-19 infection results in cytokine storms and results in the elevation of various inammatory markers (procalcitonin, ferritin, CRP, IL2R, IL-6, IL-8, IL-10, TNF-α, LDH, high sensitivity CRP to lymphocyte ratio, etc.). The laboratory biomarkers help in forecasting the severity of
COVID-19 pandemic. The present retrospective study was conducted in Acharya Shri Chander College of Medical Sciences (ASCOMS) with the
aim to determine the various inammatory markers; such as, Interleukin-6, Ferritin, Procalcitonin and D-Dimer among COVID-19 patients. In this
study the data of 500 patients were evaluated and categorized into two groups (group-I consist of 350 COVID-19 positive patients and group-II
consist of 150 COVID-19 negative patients). The majority of the cases were in the age group of 40-49 years (29%) and the male to female ratio of
1.47:1. 70% patients had positive RTPCR and 30% patients had negative RTPCR. The most common symptoms among COVID-19 positive
patients was fever both the groups. There was a statistically signicant difference (p<0.5) between the COVID- 19 +ve and COVID- 19 – ve
patient's inammatory markers. It was concluded that early investigation of inammatory markers should be done which will give a favourable
prognosis.
OCULAR ASSOCIATIONS OF METABOLIC SYNDROME AT TERTIARY HEALTH CARE CENTRE -A CROSS SECTIONAL STUDY
Authors: Manjunath Naik Keerti , C. Bubanale Shivanand , S Chougule Nagbhushan , Kurbet Bhagyajyothi , Premanandan Reshma , Kachoriya Ruchi
Published: November 2024

Introduction: The increased prevalence of metabolic syndrome is becoming a significant public health challenge. Association of metabolic
syndrome to age related cataract, glaucoma, macular degeneration and intraocular pressure has been emphasized in several studies. The present
study was carried out to assess the ocular manifestations in metabolic syndrome. Methodology: The current study was the hospital based
prospective cross-sectional study of Ocular associations of metabolic syndrome conducted among 20-80 years old patients. Results: Total 102
study subjects were enrolled in this study. The mean age of subject was 55.85 ± 11.08 years. Ocular manifestations exhibit a significantly higher
mean age compared to those without ocular manifestations (p <0.001). There was increased association of ocular manifestations amongst diabetic
and Hypertensive patients. Conclusion: The findings of this study concluded that patients with age between 45 to 65 years were more at risk of
developing ocular manifestation in metabolic syndrome. Cataract was the most common ocular manifestation followed by diabetic & hypertensive
retinopathy. Where as Glaucoma & ARMD were diagnosed in equal prevalence followed by lid Xanthoma and central retinal vein occlusion.
RELATIVE ENERGY DEFICIENCY IN SPORT (RED-S): ADULT FEMALE CLUBLEVEL SWIMMERS
Authors: Dinyar Chinoy Danesh , S. Satra Shreeya.
Published: November 2024

Background: Relative Energy Deciency in Sport (RED-S) occurs when there is an imbalance between energy intake and expenditure, impacting
athletes' health and performance. The Low Energy Availability in Females Questionnaire (LEAF-Q) is a widely used validated screening tool for
RED-S in athletes, assessing early symptoms of energy deciency in women with 90% specicity and 78% sensitivity, making it easy and
inexpensive to implement. Aim And Objectives: The study aims to evaluate the prevalence of RED-S among adult female club-level swimmers
using the LEAF-Q. It aims to identify the proportion of swimmers at risk, assess symptoms, and analyse the relationship between body composition
and RED-S risk. The study also aims to identify differences in RED-S risk among different age groups. Methods:Asurvey-based cross-sectional
study was conducted on 118 adult female club-level swimmers from Mumbai. Participants completed the LEAF-Q, with additional data collected
on age, body composition (BMI), and related symptoms. Results: More than half of the swimmers (58.47%) are at risk of RED-S. A total of 69
swimmers are classied as at risk of RED-S, with 97.46% reporting symptoms linked to injury risk. Menstrual irregularities affect 43.22%, while
38.14% report gastrointestinal issues. A negative correlation is observed between BMI and LEAF-Q scores, indicating a higher risk with normal
body composition. Conclusion: The study concludes that a signicant proportion of adult female club-level swimmers are at risk of RED-S these
ndings emphasize the need for increased awareness and preventive strategies to address RED-S in female swimmers.
A PROSPECTIVE RANDOMIZED COMPARATIVE STUDY OF CHROMIC CATGUT VERSUS VICRYL RAPIDE FOR EPISIOTOMY REPAIR IN PRIMIGRAVIDA
Authors: V Vinutha , N Usharani , K Chandrashekar , P Hanchinal Shailan
Published: November 2024

Background: Episiotomy is a surgical incision which is made in the perineum to enlarge the vaginal opening for child birth.The choice of suture
material used for episiotomy repair plays a pivotal role in the healing process. Suture materials should provide adequate tensile strength, facilitate
tissue approximation, minimize tissue reaction, and eventually dissolve without the need for removal. Two commonly used absorbable sutures for
episiotomy repair are Chromic Catgut and Vicryl Rapide. These materials differ signicantly in terms of their handling properties, absorption rates,
and tissue reactions. Understanding their comparative effectiveness is essential for optimizing postpartum recovery. Aim: This study aims to
investigate the comparative outcomes of using Chromic Catgut 1-0 versus Vicryl Rapide 2-0 for episiotomy repair in primigravida women. By
focusing on key outcomes such as perineal pain, wound healing, and complications, this research seeks to provide evidence-based
recommendations for clinical practice. Methodology: This prospective observational study was conducted in Department of OBG, Ballari
st st Medical College and Research Centre, Ballari, between 01 August 2023 to 31 January 2024. Aminimum of 240 cases were included in the study.
The local Institutional Board of Ethics approved the study and after taking an informed written consent and after fullling the inclusion criteria
patients were enrolled for the study. Results: The results were studied by comparing perineal pain,edema, temperature, redness, and wound
discharge between Vicryl Rapide and Chromic Catgut groups at postnatal days PND 2, 7, and 42. The results demonstrated that women in the Vicryl
Rapide group had signicantly lower rates of edema, redness, wound discharge, and temperature elevation compared to those in the Chromic
Catgut group at various time points. These ndings suggest that Vicryl Rapide may lead to better healing outcomes and reduced post procedural
complications. Conclusions: This study demonstrated that Vicryl Rapide2-0 was superior to Chromic Catgut1-0 for episiotomy repair in
primigravida women, offering signicant advantages in terms of reduced perineal pain, better wound healing, and reduced post procedural
complications. Vicryl Rapide2-0 showed faster recovery, with a statistically signicant reduction in pain levels on postnatal days 2 and 7 compared
to Chromic Catgut. Additionally, the Vicryl Rapide2-0 group exhibited lower rates of edema, redness, wound discharge, and temperature elevation,
which suggests better wound healing and fewer complications. Although both suture materials facilitated healing over the postpartum period,
Vicryl Rapide2-0 consistently outperformed Chromic Catgut1-0 in terms of patient comfort and wound recovery
The effect of climate change on spatio-temporal activity in burrowing frogs of the Smilisca group
Authors: Encarnación-Luévano Alondra , Sigala-Rodríguez J. Jesús , Quintero-Díaz Gustavo E. , Silva Briano Marcelo , Rojas-Soto Octavio
Published: November 2024

Measuring the potential effects of future climate changes on the spatio-temporal variance of optimal conditions for seasonal species is a key conservation issue. This study assesses the impact of climate change on the spatial and temporal patterns of optimal conditions for activity in two burrowing frogs, Smilisca fodiens and S. dentata. Ecological Niche Modeling was used to implement niche seasonality models, with calibration performed during the peak activity (July). These models were then transferred to current and future conditions for the remainder of the year, predicting future scenarios up to 2070 with an intermediate trajectory greenhouse gas concentration of 4.5 W/m2. Climate change transferability was assessed for four potential scenarios: 1) high precipitation and low temperature, 2) high precipitation and high temperature, 3) low precipitation and low temperature, and 4) low precipitation and high temperature. We examined the impact across future projected areas and analyzed geographic change trends based on latitude, longitude, and elevation. For both species, the best scenario would involve increased precipitation in the future. However, the worst-case would be a combination of reduced precipitation and higher temperatures. Due to large area loss, northern populations of S. fodiens may be highly vulnerable. Concerning S. dentata, the outlook is worrisome, with all known populations experiencing losses in most months. Area gains may not help either species since they tend to occur at elevations above their known ranges. Using a seasonal approach in spatio-temporal analysis enhances comprehension of the behavioral adaptations of seasonal species and their vulnerability to current and future climatic variations.
Potential impacts of AluYa5 (ACE & PROGINS) and AluYb8 (MUTYH) insertions in panic disorder
Authors: Yegin Zeynep , Sarisoy Gokhan , Uzun Ahmet , Koc Haydar
Published: November 2024

Objective: The human genome contains numerous active transposable elements (TEs), including the inserts of young Alus such as AluYa5 and AluYb8. The rapid, human lineage-specific evolution of brain size may be influenced by natural selection and the genomic variation of TEs, which can act as catalysts of evolution. Given their potential effects on human brain development, Alu elements may also be relevant in exploring complementary approaches for psychiatric disorders. This study analyzed the potential impacts of three specific Alu insertions (AluYa5-ACE, AluYa5-PROGINS, and AluYb8-MUTYH) on the susceptibility to panic disorder (PD). 
Materials and Methods: Alu insertions were determined with Polymerase Chain Reaction (PCR) method in 120 PD patients and 120 healthy control individuals and analyzed with logistic regression. The associations of the investigated Alus with both categorical and quantitative demographic-clinical variables including the Panic Disorder Severity Scale (PDSS) were analyzed using Fisher's exact and Kruskal-Wallis tests.
Results: AluYa5-PROGINS and AluYb8-MUTYH did not show an association with panic disorder risk. For AluYa5-ACE, a statistically significant association was determined; logistic regression analysis proved the highly protective effect (47.9%) of I/D genotype against PD compared with D/D genotype (p=0.030, OR=0.521, 95% CI=0.290-0.937). Alu insertions were not associated with panic disorder severity (p>0.05).
Conclusion: This is the first combined study in which the potential effects of three Alu insertions in terms of both PD susceptibility and possible association with several disease parameters were evaluated. Further studies about the roles of the Alu elements in the etiology PD are highly recommended.
Forecasting the Metal Ores Industry Index on the Tehran Stock Exchange: A Gated Recurrent Unit (GRU) Approach
Authors: Moghadam Reza Javadpour
Published: November 2024

This research offers an in-depth examination of predicting the closing prices of the metal ores industry index on the Tehran Stock Exchange (TSE) using a Gated Recurrent Unit (GRU) model. The GRU, a type of recurrent neural network, shows great promise for tasks involving time series forecasting. The historical daily price data from October 2017 to October 2022, was used in the study after carefully preprocessing it for further analysis. The study begins with a univariate analysis to reveal distribution characteristics and the relationships between essential variables. A customized GRU model that is trained on 70% of the time series data, with its performance assessed through metrics such as Root Mean Square Error (RMSE), Mean Square Error (MSE), Mean Absolute Error (MAE), and the R-squared (R2) score is used for prediction. The results indicate that the GRU model provides accurate predictions for the metal ores industry index, outperforming traditional forecasting techniques. The model's recurrent nature enables it to capture both short-term and long-term temporal dependencies within the data. This research highlights the significant potential of GRU networks in the realm of financial forecasting. Future improvements will focus on hyperparameter optimization and further integrating additional input variables to enhance predictive accuracy.
DESBLOQUEANDO A CURA DO HIV: O POTENCIAL DO CRISPR-CAS9 PARA MODIFICAR GENES E ELIMINAR RESERVATÓRIOS VIRAIS
Authors: Coradi Burille Bernardo , Leal Neto Hugo de Sousa , Merino Machado Milena , Bailo Davit Willian , Cattusso Casagrande Larissa
Published: November 2024

O HIV (Vírus da Imunodeficiência Humana) continua sendo um dos maiores desafios da saúde pública global, afetando milhões de pessoas em todo o mundo. Embora a terapia antirretroviral (TAR) tenha prolongado significativamente a vida de indivíduos infectados, ela não é capaz de erradicar o vírus devido à existência de reservatórios virais latentes, nos quais o DNA proviral do HIV permanece integrado ao genoma das células hospedeiras. A tecnologia CRISPR-Cas9, uma ferramenta de edição gênica de alta precisão, oferece uma nova abordagem para enfrentar essa limitação, permitindo a remoção direta do DNA proviral ou a modificação de genes essenciais para a entrada e replicação do HIV, como o CCR5 e o CXCR4. Este artigo revisa os avanços recentes na aplicação do CRISPR-Cas9 no controle do HIV, com ênfase na excisão do DNA proviral, na modificação de genes do hospedeiro fundamentais para a infecção e na eliminação dos reservatórios virais latentes. A aplicação do CRISPR-Cas9 tem demonstrado resultados promissores em estudos pré-clínicos, reduzindo significativamente a carga viral e inativando o HIV em modelos celulares e animais. Avanços no desenvolvimento de variantes mais precisas da enzima Cas9, sistemas de entrega aprimorados e abordagens combinadas com outras terapias, como a reativação de reservatórios latentes e a imunoterapia, oferecem novas perspectivas para superar essas barreiras. A tecnologia CRISPR-Cas9 tem o potencial de revolucionar o tratamento do HIV, mas sua implementação clínica ainda requer refinamentos técnicos e a solução de questões éticas, particularmente no que diz respeito à edição genética humana. Este artigo explora os progressos, limitações e futuras direções dessa abordagem, discutindo o papel que essa tecnologia pode desempenhar no caminho para a erradicação do HIV.