bluuebunny/crossref_metadata_2025 huggingface dataset:
Antimicrobial susceptibility pattern of pathogens from urinary isolates of diabetic patients in a tertiary care hospital in South Tamil Nadu
Authors: Sheeba S Nightingale
Published: July 2023

Since diabetes has several negative effects on the urinary tract and host immune system, urinary tract infections (UTIs) pose a serious health issue for diabetic people. The majority of individuals with defective genitourinary tracts get complicated UTIs. To avoid morbidity and significant life-threatening conditions linked to co-morbid diabetes and UTIs, quick diagnosis and treatment are required. Effective care of these patient groups will be facilitated by knowledge of the many bacterial agents that cause UTI in diabetes patients and non-diabetic patients, as well as their susceptibility profiles.

: This cross sectional study, which was conducted in a tertiary care hospital Virudhunagar, South Tamil Nadu, is aimed to compare the prevalence of UTI, the causative bacteria, and their antibiotic susceptibility profiles in diabetic patients (168) and non- diabetics (150). The existence of urinary tract bacterial pathogens was determined by microbiologic analysis of a urine sample that was collected aseptically. The Kirby Bauer technique was used to screen the isolates for drug susceptibility in order to determine their patterns of antibiotic resistance.

: Urinary tract bacterial infections were found in 37.5% and 36.6% of samples from diabetes and non-diabetic people, respectively. species, , and () were the organisms present in the urine samples in the following proportions for the diabetic and non-diabetic individuals, respectively: 34.92% and 29.09%, 12.69% and 10.9%, 7.93% and 12, 6.34% and 5.45%, 3.17% and 1.81%, 3.17% and 0, 22.2% and 16.36%, 9.52% and 14.54% and 0 and 9.09%. Nevertheless, the difference in the percentages of isolated bacteria was not statistically significant (-value = 0. 856). The majority of the antibiotics tested on bacteria isolated from diabetic and non-diabetic people were extremely effective, particularly Meropenem, Amikacin, Gentamicin, Piperacillin – tazobactam and Nitrofurantoin for gram negative bacteria and Vancomycin and Amikacin for gram - positive bacteria.

: The current study's findings highlight the necessity of doing sensitivity testing before beginning antibiotic therapy for UTI since they might aid in the right selection of antibiotics, ensure that they are used effectively, and thus avoid antibiotic resistance.
On Understandings of Politeness in Greek, Again!
Authors: Sifianou Maria
Published: July 2023

Recent discursive approaches to im/politeness have emphasised the significance of exploring non-academic understandings of im/politeness. Pursuing this line of research, the data for this paper come from a questionnaire distributed to 100 undergraduate female university students. The informants were asked to provide some attributes of a polite person and offer examples of a person or behaviour that impressed them as being polite. The aim was to elicit the respondents’ perceptions of what constitutes politeness. 

The results show that the prevalent attributes of a polite person for these informants are helpfulness and unconditional respect, along with kindness. These constitute a web of closely related concepts based on goodness and genuine concern for the other, with respectfulness and kindness probably motivating helpfulness. This finding suggests that non-academic understandings of politeness are broader and not confined to language use, which has been the locus of most im/politeness research.
Advances in the Application of Apoptotic Proteins and Alternative Splicing in Tumor Therapy: A Narrative Review
Authors: He Jin , Qiu Weitao , Li Yonghong , Wei Chaojun , Bai Zhongtian , Jia Jing , Cai Hui
Published: July 2023

An apoptosis-resistant state determined by apoptotic protein expression is commonly seen in the initiation, progression, and treatment failure stages of human cancer, and anti-tumor drugs targeting apoptotic proteins have been increasingly developed over the past three decades. However, the frequently alternative splicing of apoptotic proteins diminished the ability of targeting drugs to bind to apoptotic proteins and, consequently, limit the drug efficacy. Currently, accumulating evidence has demonstrated that many alternative splicing events have been associated to apoptosis resistance in different cancers. Therefore, the intervention targeting alternative splicing for regulating tumor cell apoptosis is expected to become a new strategy and new direction of antitumor therapy. Here, we present well established alternative splicing events that occur in different apoptosis-related genes and their modification by several approaches with cancer therapeutic purposes.
Inhibiting the Proliferation of Colorectal Cancer Cells by Reducing TSPO/VDAC Expression
Authors: Liu Yang , Wang Shuyue , Yang Weining
Published: July 2023

Background: We aimed to explore the mechanism of the effect of remimazolam (Rem) on the proliferation of colorectal cancer (CRC) cells with CRC as a disease context.
Methods: Translocation protein (TSPO) expression in CRC was determined by Western blotting and qRT-PCR in the Second Affiliated Hospital of Qiqihar Medical University from March 2019 to February 2022. TSPO-interacting proteins were predicted through string database. The proliferation was measured by CCK-8 and 5-ethynyl-2-deoxyuridine (EDU). The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) and clonal colony on cells were formed to screen for the optimal concentration of Rem and to detect the viability. The expression of apoptosis-related proteins, Bcl-2 and P53, was determined by qRT-PCR and Western blotting. The effect of Rem on the expression of tumor markers, CEA and CA19-9, in CRC was examined through ELISA.
Results: TSPO expression in CRC tissues and cells was higher than that in ANT samples and normal intestinal epithelial cells. Over-expression of TSPO promoted the proliferation of HCT116 and the expression of tumor markers CEA and CA19-9 and inhibited the apoptosis of HCT116. Interference with TSPO inhibited the proliferation of HCT116 and the expression of CEA and CA19-9 and promoted the apoptosis of HCT116. 1 μg/mL Rem could inhibit the viability of HCT116, the proliferation of HCT116 and the expression of CEA and CA19-9, and improve the apoptosis of HCT116. TSPO could interact with VDAC and affect its protein expression, and Rem could inhibit the proliferation and the expression of CEA and CA19-9 through the TSPO/VDAC pathway, to promote its apoptosis.
Conclusion: Rem affects the proliferation of CRC cells by inhibiting the TSPO/VDAC pathway.
Comparing the Effectiveness of Two New CPR Training Methods in Korea: Medical Virtual Reality Simulation and Flipped Learning
Authors: Kim Eun-Ae , Cho Keun-Ja
Published: July 2023

Background: We compared the educational effects of two training methods that have gained momentum: medical virtual reality (medi-VR) simulation and flipped learning.
Methods: Firefighters (n=128; 116 men and 12 women; mean age=28 years) in training from the Emergency Educational Simulation Center of Korea National Fire Service Academy, Gongju-si, Korea, were randomly assigned to two groups: medi-VR simulation and flipped learning in 2022. The participants were trained to perform cardiopulmonary resuscitation (CPR) using medi-VR simulation and the flipped learning methods. CPR self-efficacy, knowledge, performance, class immersion, and class satisfaction were compared between the groups. To analyze educational effects, paired and independent t-tests were performed.
Results: The post-education scores for CPR performance knowledge and CPR performance were significantly higher in the medi-VR simulation group compared to the flipped learning counterparts (P<0.001). Moreover, despite the lack of a significant difference between the groups, post-education scores for self-efficacy, class immersion, and class satisfaction showed a positive effect on learning.
Conclusion: Medi-VR simulation can be utilized as effective educational intervention, while providing a new direction for teaching methods.
Risk Factors for Potential Drug-Drug Interactions in Outpatients with Dyslipidemia
Authors: Lalatović Ninoslava , Pantović Snežana , Nedović-Vuković Mirjana , Kostić Marina
Published: July 2023

Background: Patients with dyslipidemia are usually multimorbid and require polypharmacy. Therefore, it is important to identify potential drug-drug interactions (pDDIs) in time to prevent their consequences. We aimed to identify and analyze risk factors contributing to their occurrence to guide health professionals.

Methods: A prospective cross-sectional study of 216 outpatients with dyslipidemia was conducted from May 2021 to April 2022 in Podgorica, the capital of Montenegro. pDDIs were identified using Medscape, Epocra- tes, and Drugs online interaction checkers. Multivariate regression analysis was performed to evaluate the po- tential predictors of interactions.
Results: pDDIs were detected in 212 (98.1%) participants, whereas pDDIs with high clinical significance were detected in 25.46%, 40.74%, and 58.8% of subjects by Drugs, Epocrates, and Medscape, respectively. Polypharmacy emerged as a risk factor for the occurrence of pDDIs in all three checkers in each category of clinical significance. The use of non-steroidal anti-inflammatory drugs and antiplatelet drugs contributes to the incidence of severe pDDIs B=1.014, 95%CI 0.681-1.346, P=0.000 and B=0.492, 95%CI 0.286-0.698, P=0.000, by Epocrates and Medscape respectively. The number of prescribers per patient was a protective factor against moderate pDDI B= -0.858, 95%CI -1.572-(-0.144), P=0.019 and B= -0.956, 95%CI -1.671-(- 0.241), P=0.009, by Medscape and Epocrates, respectively, but a risk factor for the occurrence of minor pDDIs B=0.373, 95%CI 0.033-0.712 P=0.032 and B=0.143, 95%CI 0.042-0.244, P=0.006, by the same checkers.

Conclusion: Knowledge of the risk factors contributing to the occurrence of pDDIs is important for the development and implementation of strategies for their prevention, and given the high prevalence of dyslipidemia, understanding these factors seems crucial nowadays.
Utilization of Activated Carbon Catalyzed Ozonation (ACCO) For Removal of Ciprofloxacin and Vancomycin from Hospital Wastewater
Authors: Ghozikali Mohammad Ghanbari , Mohammadpour Ahmad , Dehghanzadeh Reza
Published: July 2023

Background: Hospital wastewater is considered by health and environmental researchers due to the presence of various hazardous chemical contaminants such as residual of antibiotics and other drugs. The conventional treatment processes are not able to complete removal of them, and could lead to the entry of these compounds into the environment. Then, we aimed to analyze and evaluate the removal of ciprofloxacin and vancomycin antibiotics from hospital wastewater.
Methods: The effect of antibiotic concentration and reaction time was investigated on the performance of single ozonation (SOZ) and activated carbon catalyzed ozonation (ACCO). In addition, COD and BOD of the effluent, antibiotics degradation kinetics and mathematical modeling were determined. Solid phase extraction columns (SPE) and high-performance liquid chromatography (HPLC) methods were used to extract and measure the intended antibiotics, respectively.
Results: The results of this study showed that degradation of both antibiotics follow pseudo-first order kinetic. SOZ was able to eliminate 6 mg/L of vancomycin and ciprofloxacin within 45 and 65 min, respectively. Due to the synergistic effect of activated carbon on ozonation, ACCO significantly reduced the degradation time to 20 and 25 minutes, respectively. BOD/COD ratio at the outlet of ACCO process increases from 0.2 in raw wastewater to 0.4 in treated wastewater, which could be appropriate for biological treatment.
Conclusion: ACCO could be considered an efficient process for degradation of antibiotics in hospital wastewater.
Reconstruction of SCM Performance Measurement Model for Halal Industry
Authors: Maharani Satia Nur , Nurhandayani Anik , Putri Dhika Maha
Published: July 2023

One pattern of Islamic business that is growing rapidly in both Muslim and non-Muslim majority countries is the halal industry. [1] emphasized that in its development, the halal industry has an important issue that needs to be addressed immediately, namely the need for performance measurement tools. So far, there is no instrument as a tool to measure performance that is able to comprehensively assess all Supply Chain Management (SCM) in the halal industry. SCM of the halal industry is motivated by the industry’s desire to meet the demands of Muslim consumers who want to ensure that what is consumed is guaranteed halal, not only from the status of the ingredients but all aspects involved in the business process [7]. Therefore, the halal industry due to ideological differences requires a performance paradigm shift in the form of a performance measurement tool that is not limited to profit achievement but compliance with Islamic values [2]. The halal industry is said to perform well when SCM is focused on a “holiness” approach through maslahah (welfare) [19].Therefore, through a qualitative approach, this study seeks to develop indicators to measure the performance of Halal Supply Chain Management specifically for the halal industry. The results of the study found that the performance measurement model for HSCM consists of quantitative and qualitative indicators. Aspects of obedience to Islamic principles to achieve halal integrity are not always able to be measured with quantitative techniques, therefore it is necessary to reconstruct qualitative indicators. Further research can be done by implementing the HSCM performance measurement model specifically for the halal industry.
Keywords: Halal Industri, Halal Supply Chain Management, Indicator Perfomance
Juridical Study Allocation Village Fund
Authors: Pebrihariati.R Dr. Sanidjar , H. S. , H. M.
Published: July 2023

Specifically regarding villages, it is regulated in Law Number 6 of 2014 concerning Villages. Of the 34 provinces in the Republic of Indonesia, it is divided into respective districts/cities. Based on this description, the authors are interested in researching ”Juridical Study Village Fund Allocation”. Writing problems: 1) What is the impact of Village Fund Allocation in increasing development in the village?. 2) What are the legal consequences of accountability for Village Fund Allocation if there is no Village Government in that area? This writing uses a normative legal approach. The type of data used is secondary data, and analyzed using qualitative analysis. Conclusion: 1) That the impact of village fund allocation can increase development in the village. The basic thing that must be done by the village apparatus is to make medium/long term planning by focusing on one or two programs/activities that are capable of making a major contribution to society. 2). Whereas the legal consequence of accountability for Village Fund Allocation if there is no Village administration in that area is the Regional Head of the lowest Regional Government in that area
Keywords: Allocation of Funds, Village Government
Understanding and Expectations of the Students of Fakultas Keguruan Dan Ilmu Pendidikan Universitas Bung Hatta About Sumbang Duo Baleh
Authors: Fikri Hasnul , . Syofiani , Isnanda Romi , Morelent Yeety , Rosha Zeshasina
Published: July 2023

This study aims to describe the students’ understanding and expectations of the FKIP Universitas Bung Hatta about sumbang duo baleh . This research is qualitative research with a descriptive method. The data is in the form of students’ verbal responses to an unstructured questionnaire via Google-forms. Student responses are translated into keywords. The trend of responses is analyzed through simple statistics (percentages). The results of the study show that most students are still familiar with the term sumbang duo baleh. They know this term through non-formal, formal, and informal sources. In general, students can explain the meaning of sumbang duo baleh well and consider the norms still relevant in the digital era. They expect that sumbang duo baleh will be disseminated, taught, preserved, implemented, and developed, especially amid the threat of foreign cultural intrusion related to the globalization process.
Keywords: expectations, culture, Minangkabau, sumbang duo baleh, understanding
A Review on Hybrid Work and Work Performance During Post-Pandemic
Authors: Kamis Jamilah , Abd. Rahim Zulkiflee , Yusoff Yuslina , Azilah Husin Nor , Yuliviona Reni
Published: July 2023

The purpose of this article review is to investigate the relationship between hybrid work and work performance post-pandemic Covid-19. The analysis is based on several publications pertaining to the impact of the post-COVID-19 pandemic on the perspective on hybrid work and work performance. A search in the Google Scholar database using the search string [”Hybrid work” AND “Work Performance” AND ”Post Pandemic”] was conducted in September 2022. Several documents were then filtered based on the criteria needed according to the PRISMA stages, such as year of publication, subject areas, type of document, category of access, and English language. Data was gathered from relevant papers published during the post-pandemic that occurred from 2020 to 2022 in the field of human resources, management, social science and humanities. After being reviewed for eligibility, only the most pertinent documents were chosen for further investigation. The findings suggested, to meet the new and emerging needs of hybrid workers, both physical and digital workplaces must be revamped in response to the post COVID-19 pandemic
Keywords: Hybrid work; Work Performance; Post Pandemic; Covid-19
Systemic Bank in the National Banking's Legal System
Authors: Novira Elyana
Published: July 2023

Disrupted banking system may lead to financial risk as its characteristics links one market to another and one financial service institution to another. If a bank fails, another bank may do so, and even non-banking system, financial system and generally domestic macroeconomics and other states may fail; thus, systemic risk attracted both central bank and banking supervising institutions’ attention throughout world. This study wants to answer the question: Why a bank is called Systemic Bank and how is the Systemic Bank regulation in national banking system? The descriptive analytic research used normative approach, with secondary data. The study found that a bank is called systemic as the banking world’s default risk can be systemic related to its transmitting ability, and a bank’s failure can contribute to another’s failure in banking transaction. The effect of default bank can spread to non-financial companies for the bank provides loan to other companies. The Law No.9 of 2016 about Prevention and Management of Financial System Crisis is published leading to the regulation about the assignment of Systemic Bank. Coordinating with Bank of Indonesia the OJK assigns Systemic Bank and Capital Surcharge semiyearly in normal condition. The method of assignment is implemented with several indicators: size, complexity and interconnectedness. If OJK decides earlier the measures to be taken to deal with the Recovery Plan that cannot make the bank sound, recommendation given will be to publish publicly the list of Systemic Banks to give appropriate information and law protection to the public.
Keywords: Systemis Bank, Legal System, National Banking
Las cooperativas indígenas: entre los derechos a la autonomía y la libre determinación de los pueblos indígenas y su plan de vida
Authors: Vargas-Chaves Iván
Published: July 2023

Este artículo tiene por objetivo estudiar las cooperativas indígenas como un modelo asociativo sui generis que comparte algunos rasgos con los modelos asociativos propios del cooperativismo moderno; planteando, además, un gran reto para el Derecho cooperativo, en tanto que existen tensiones entre ambas formas de concebir la cooperación, y que generan un escenario óptimo de debate. La metodología utilizada es de corte cualitativo mediante un análisis documental de la información recopilada en distintas fuentes. En el marco de un diseño exploratorio-descriptivo, se analizó la normatividad sobre cooperativas y derecho de pueblos indígenas, además de varios casos de estudio. Como resultados, se presentan los puntos de contacto y las tensiones entre estas dos formas de ver la cooperación en pro de un desarrollo social y económico; exponiendo así un conjunto de reflexiones que sitúan al Derecho cooperativo como aquella rama que puede llegar a articular las cooperativas indígenas a los postulados del cooperativismo moderno.
On the Insufficiencies of the Current Legislative Regime Regarding Physician-Patient Mediation in the Professional Liability of Physicians. A Critical Analysis of the Polish Solution
Authors: Bek Dominika , Hanc Jakub
Published: July 2023

The article presents a critical opinion on physician- patient mediation conducted in the context of proceedings on the professional liability of physicians. The starting point is the Act on Medical Chambers, which provides for the possibility of conducting a mediation between the accused physician and the aggrieved patient. This regulation is unique in the region. Its specific measures, such as, for example, the choice of a mediator among physicians, have undergone a critical assessment in the literature. As a rule, the need for the functioning of mediation in the context of professional liability is not called into question. However, a thorough analysis of the assumptions of mediation and restorative justice and the function of professional liability of physicians suggests going a step further. Although the physician-patient conflict certainly requires conciliatory solutions, it seems that the disciplinary regime does not provide an adequate foundation for agreement because it is unable to secure the aggrieved person’s interests.
Toxic Parent in A Thousand Perfect Notes by C.G. Drew
Authors: Alya Mazaya Shauqina
Published: July 2023

This study examines the portrayal of a toxic parent in C.G. Drews's novel, A Thousand Perfect Notes, explicitly focusing on the mother's role in forcing her child to become a pianist. The research addresses two mainobjectives: the first is to describe the forms of toxic parenting exhibited by the mother in the novel, and the second is to explore the effects of toxic parenting on the child's character in A Thousand Perfect Notes. Toachieve this, the researcher applied Dr. Susan Forward's theory of toxic parents from 2002, utilizing a psychological approach for analysis. In addition, the study utilized a psychology-focused literary criticismapproach, focusing on the character's parenting style. The findings revealed several forms of toxic parenting depicted in the book, including insufficient parenting, controlling behavior, verbal abuse, and physicalabuse. The main character, in particular, experienced the impacts of these toxic parent characteristics. The study's analysis shed light on the effects of a toxic parent on a child, as portrayed in C.G. Drews's A ThousandPerfect Notes.
Note sur une association de Clostridium novyi type A et Clostridium sordellii dans un cas de grangrène gazeuse chez une vache Zébu
Authors: El Sanousi S.M. , Musa M.T.
Published: July 2023

Les auteurs décrivent un cas de myosite à gangrène gazeuse sur une vache Zébu avec association de Clostridium novyi type A et Clostridium sordellii. La présence simultanée de ces deux organismes dans la même lésion est une rareté. Le diagnostic différentiel avec le charbon symptomatique est difficile en l'absence d'examens bactériologiques. Une cause, d'origine iatrogène, est probable et l'introduction de spores par le matériel d'injection lors des campagnes de masse contre le charbon symptomatique ne peut être écartée. L'animal guérit complètement après injection intramusculaire de TerramycineND pendant 4 jours successifs.
Dyserythropoiesis dans la trypanosomose animale
Authors: Igbokwe I.O.
Published: July 2023

L'hémolyse est la cause pathologique la plus évidente de l'anémie trypanosomienne. Les anémies hémolytiques s'accompagnent normalement d'une érythropoïèse accrue, d'une réponse réticulocytaire et d'une augmentation du volume moyen corpusculaire des érythrocytes circulants. Dans la trypanosomose, l'anémie s'accompagne d'une perturbation de l'érythropoïèse. Ce fait semble découler d'une réponse leucocytaire subnormale chez les rongeurs infectés, faible ou nulle chez les ruminants (infectés) et d'une capacité faible d'érythrogénèse du plasma de mouton infecté chez la souris. Le volume corpusculaire moyen augmente dans la phase aiguë pour atteindre un sommet 3 à 4 semaines après l'infection. Il chute jusqu'à la normale ou en-dessous de la normale pendant la phase chronique, ce qui indiquerait que l'érythropoïèse augmenterait modérément dans la phase aiguë, mais décroît progressivement, au point de devenir nulle, au cours de la phase chronique. Les raisons de la dysérythropoïèse ne sont cependant pas claires mais peuvent être associées à un trouble érythrocytaire, à une synthèse ralentie ou insuffisante de l'érythropoïétine, à une baisse de la synthèse de l'hémoglobine, ou à une combinaison interréactionnelle de ces facteurs. Dans ces différents domaines, il est évident que des études poussées sont nécessaires.
Faible taux glossinaire dans les plaines d'Accra et perspectives de développement de l'élevage
Authors: Marchot P. , Leroy P.L. , Janicot Serge , Guillot B.
Published: July 2023

Le Ranch d'Elevage d'Aveyime, situé au Ghana dans les plaines d'Accra est un centre de sélection bovine. La conformation du cheptel West African Shorthorn y est améliorée par croisement avec des zébus White Fulani. Un microclimat très sec caractérise la plaine par rapport aux régions qui se trouvent sous les mêmes latitudes. La rareté de la mouche tsé-tsé, et par suite, de la trypanosomose en sont des conséquences qui permettent une telle amélioration génétique. Celle-ci doit être poursuivie, étant donné qu'aucun facteur susceptible de modifier les conditions climatiques, donc la répartition des mouches, ne doit se manifester.
Mapping blended learning in social work practice education to national standards - a Hybrid Placement Model Teaching and Learning Resource
Authors: O'Connor Erna , Whiting Sinéad
Published: July 2023

In Ireland as elsewhere, the Covid-19 pandemic and ensuing public health restrictions, gave rise to an unprecedented crisis in health and social care service provision, leading to cessation of student social work placements in March 2020.   The Hybrid Placement Model Teaching and Learning Resource was developed to ensure that quality practice-based placements could resume and continue to be viable during subsequent phases of the Covid-19 pandemic.  Combining four elements of onsite practice, off-site practice, online practice, and reflective practice the model provided a ‘road map’ that supported both practice teachers and students as they navigated placements within this context. Through provision of a user-friendly diagram and detailed practical examples of blended learning opportunities mapped to each of the eighty-three national standards of proficiency, the resource enabled practice teachers and students to visualise a range of practice learning opportunities that could be undertaken as part of a blended placement and provided assurance that blended learning met regulatory requirements.

In this article the authors discuss the context and rationale for the model and describe its four integrated components. The usefulness of the model in supporting optimal learning on hybrid placements is addressed and its potential post Covid-19 restrictions is considered.
Modification of transsternal occlusion of the main bronchus by plastic surgery of the anterior mediastinum with a mesh implant in the surgical treatment of widespread destructive pulmonary tuberculosis
Authors: Tarasov R. V. , Sadovnikova S. S. , Krasnikova E. V. , Bagirov M. A.
Published: July 2023

An observation from practice is given – surgical treatment of a patient with widespread destructive pulmonary tuberculosis due to a modified technique of transsternal occlusion of the main bronchus by plastic surgery of the anterior mediastinum with a mesh implant. Patient A., 37 years old, has been suffering from pulmonary tuberculosis for 2 years. She was admitted to the clinic with complaints of shortness of breath during exercise (mrc 3), cough, back pain. On computed tomography of the chest organs: a picture of fibrous-cavernous tuberculosis of the left lung with extensive mediastinal pulmonary hernia. The patient underwent transsternal occlusion of the left main bronchus with plastic surgery of the anterior mediastinum with a polymer mesh implant. The result of the treatment was the stabilization of the process and the clinical cure of the patient.
Chemotherapy-induced broadly reactive autoantibodies in the treatment of malignancies
Authors: Shanina E. V. , Breker F. , Lysov N. A. , Shanin V. Yu. , Ponomareva Yu. V. , Supil'nikov A. A.
Published: July 2023

The aim of the study was to evaluate the relationship between chemotherapy and autoimmune reactions in patients with metastatic colorectal cancer. Cancer and autoimmunity are known to be interrelated, but until now it has been unclear to what extent chemotherapy specifically contributes to autoimmune reactions. We studied immunoglobulin M (IgM) levels in response to the administration of various human tissues before and during adjuvant chemotherapy. Patients received seven cycles of chemotherapy with the FOLFIRI plus cetuximab regimen. IgM levels against the tested tissues increased already after the first cycle of chemotherapy and continued to increase during the second and third cycles. Autoimmune responses then began to decrease from the fourth to seventh cycles, but remained elevated from baseline for most of the study tissues. Our results suggest that chemotherapy can induce a wide range of autoimmune reactions. Monitoring self-reactive IgM responses during treatment may help prevent or alleviate side effects associated with autoimmunity.
A construção interrompida do “lar do povo” e o mercado de trabalho nos países nórdicos
Authors: Wolf Paulo José Whitaker
Published: July 2023

Nos países nórdicos – Dinamarca, Finlândia, Islândia, Noruega e Suécia – o Estado assumiu um papel mais contundente no atendimento das necessidades das pessoas em substituição ao mercado e à família na provisão de bens e serviços por meio da mobilização da política econômica e da política social. Esse processo avançou após a Segunda Guerra Mundial, mas perdeu força a partir da década de 1970, sobretudo depois da crise financeira de 2008 e da crise migratória de 2015. Ainda que os países nórdicos continuem em uma posição muito mais favorável que outros países, a maior resistência em mobilizar a política econômica e a política social se refletiu na deterioração das condições do mercado de trabalho, incluindo o aumento dos empregos com contrato de trabalho atípico, o aumento dos que precisam recorrer a mais de um emprego, a piora das condições de trabalho, a elevação do desemprego e o aumento da duração do desemprego. Ainda que todos na força de trabalho tenham sido afetados, os homens, geralmente jovens, os com menor escolaridade e os estrangeiros foram os grupos mais prejudicados nesse processo.
Forças de coesão e fragmentação identificadas na Região Metropolitana de São Paulo
Authors: Costa Esdras da Silva , Prearo Leandro Campi
Published: July 2023

A pesquisa tem o objetivo de identificar as forças de coesão e fragmentação metropolitana que influenciam no processo de articulação interfederativa e formulação de políticas públicas na Região Metropolitana de São Paulo. No que diz respeito à metodologia, a pesquisa tem uma abordagem quantitativa, classificada como tipo de pesquisa descritiva. As variáveis mensuradas foram operacionalizadas por meio de uma escala de diferencial semântico bipolar, a partir de um conjunto de adjetivos, opostos e contrários (grau de concordância e grau de importância). Para a análise dos dados, a pesquisa fez uso da técnica Análise Fatorial Exploratória. Os resultados apresentam as dimensões latentes, responsáveis por explicar o conjunto das variáveis observadas. Dessa forma, foi possível relacionar as forças de coesão metropolitana sob a seguinte ordem: formulação do Plano de Desenvolvimento Urbano Integrado (PDUI); criação de uma consciência e de uma cultura metropolitana; e adequação dos objetivos do PDUI relacionados às Funções Públicas de Interesse Comum. A pesquisa também caracterizou fragilidades, apontando as seguintes fragmentações: baixa tradição em políticas regionais, ausência de capacidade técnica nos municípios e diferenças políticas e ideológicas.
Cátedra de emprendimiento en Colombia: obligatoriedad e improvisación pedagógica-conceptual
Authors: Ruano-Ibarra Elizabeth , Martinez Wilfred Fabián Rivera
Published: July 2023

Se analiza el contexto de la promulgación de la Ley nro. 1014, del 2006, y la implementación de la Cátedra de Emprendimiento en 19 Instituciones de Enseñanza Básica Secundaria y Media del municipio Popayán (Cauca, Colombia). La discusión de los datos empíricos, obtenidos mediante la aplicación de un cuestionario con preguntas abiertas al profesorado responsable por dicha cátedra, utilizó un abordaje mixto. La primera fase analítica privilegió el análisis cuantitativo de las respuestas obtenidas. Un segundo momento enfatizó el abordaje cualitativo buscando la dialogicidad entre los datos empíricos, la literatura de referencia y las fuentes documentales. Los resultados apuntan la priorización de la concepción empresarial, instrumental y economicista, del emprendimiento y, en menor expresión, prácticas curriculares diferenciadas de esa visión hegemónica. Se concluye que dicha cátedra, impuesta mediante Ley, incidió en la improvisación pedagógico-conceptual derivada de la marginación municipal de la toma de decisiones políticas en el ámbito nacional.
Direitos humanos e direito à saúde de moradores de assentamentos rurais do MST
Authors: Miwa Marcela , Moura Ana Luiza , Ventura Carla
Published: July 2023

No Brasil, o desafio para a garantia do exercício de direitos esbarra em profundas desigualdades sociais, o que fragiliza não somente a garantia de direito, como também a implementação de políticas públicas que possam sanar as demandas da população. No caso da população ligada ao campo, os profundos contrastes na distribuição de terras, de recursos e acesso a serviços fazem com que moradores de assentamentos rurais deparem-se com precárias condições de sobrevivência. O presente artigo é uma revisão sobre as potencialidades e fragilidades que membros do Movimento dos Trabalhadores Rurais Sem Terra (MST) apresentam para o exercício dos direitos humanos, especialmente do direito à saúde, a partir de referências localizadas nas bases LILACS, SciELO, Embase, Scopus, CINAHL, PubMed, Web of Science e ProQuest. Foram analisados oito artigos e identificadas três categorias principais: i) Luta por direitos e interesses partidários; ii) Direito à educação e educação em direitos; iii) Onde exercer o controle social em saúde? Os resultados evidenciaram que a defesa de seus direitos esbarra, por vezes, em interesses político-partidários; porém, o foco na educação indica forte potencial na defesa e ampliação desses direitos. No que diz respeito ao direito à saúde, os membros do movimento ainda apresentam posicionamentos contraditórios em relação a espaços formais de controle social em saúde.
Systemic inflammatory response index (SIRI) and Systemic immune-inflammation index (SII) to show Thrombus Localization in Patients with Acute Pulmonary Embolism
Authors: YILDIZ Günay , SELVİ Fatih , BEDEL Cihan , ZORTUK Ökkeş , YAVUZ Yavuz
Published: July 2023

Pulmonary embolism (PE) is a critical disease associated with mortality. Considerable markers related to this disease associated with inflammation have been used to catch thrombus localization. In this study, we wanted to examine the association between the Systemic inflammatory response index (SIRI), Systemic immune-inflammation index (SII) and thrombus localization in patients with PE. Our study consisted of patients diagnosed with PE between January 2020- June 2022. Laboratory parameters of patients diagnosed with PE, especially thrombus localization, thrombus location, SII, and SIRI, were recorded and compared with thrombus localization. One hundred patient with PE who met the inclusion criteria was incorporated in our study. When we grouped the patients according to PE localization, the thrombus was in the main pulmonary vein in 18%, in the lobar region in 51%, and in the distal pulmonary vein in 31% of the patients. In addition, mean SIRI and SII levels were encountered to be higher in patients with main pulmonary localization compared to those with thrombus in both lobar and segmental branches. SIRI has 78% sensitivity, and 72% specificity at the optimum cut-off value; in Level II, it detects thrombus with main pulmonary involvement with 66.7% sensitivity and 79.3% specificity. In patients with PE, high SII and SIRI values can be practical markers in predicting proximal thrombus.
Quarantine Disinfestation of Papaya Mealybug (Hemiptera: Pseudococcidae) Using Gamma and X-rays Irradiation
Authors: Song Zi-Jiao , Zhao Qing-Ying , Ma Chen , Chen Ran-Ran , Ma Tian-Bi , Li Zhi-Hong , Zhan Guo-Ping
Published: July 2023

The papaya mealybug Paracoccus marginatus is an invasive, polyphagous pest and poses a quarantine threat to tropical and subtropical countries. Infested commodity internationally should be undergoing phytosanitary treatment, while irradiation is recommended to replace methyl bromide fumigation. Dose-response tests were conducted on the 2-, 4-, and 6-d-old eggs and gravid females of P. marginatus using the X-ray radiation doses of 15–105 Gy with an interval of 15 Gy, respectively. Radiotolerance was compared using fiducial overlapping and lethal dose ratio (LDR) test, resulting in insignificant difference except for LDR test at LD90 (leading 90% mortality at 95% confidence level (CL)); the estimated dose for 99.9968% mortality at 95% CL was 176.5–185.2 Gy, which was validated in the confirmatory tests using gamma irradiation because gammy and X-rays have equal biological effect on pests. Therefore, a total of estimating 60,386 gravid females of papaya mealybug irradiated with 146.8–185.0 Gy resulted in no F1 nymphs developing. Eggs can therefore be used as an alternative to gravid females for dose-response tests; the recommended minimum dose for phytosanitary treatment of P. marginatus on infested commodity is 185 Gy, with treatment efficacy ≥ 99.9950% at 95% CL.
Removal of Lead (Pb(II)) from Water by Adsorption Using Nagar Parker Kaolin Clay
Authors: Azam Farhan
Published: July 2023

Clean water is now very rare due to the increased water pollution causing many diseases. Heavy metals mainly lead from industrial waste i.e. batteries, cable sheaths, machinery manufacturing, shipbuilding, lead oxide and radiation protection is accountable & largely contributed lead in river and canal waters. Presence of lead in water is hazardous to life due to many reasons. It can cause cancer, weakness, anemia, kidneys, high blood pressure and nerve diseases. Inorganic lead is reported to me more dangerous than organic one. Industries including batteries, cable sheaths, machinery manufacturing etc. drains water that has soluble lead ranging from 200 – 500 mg/L. The safe limit of lead in water is about 0.015 mg/L. Pakistan is a country rich in minerals. It has about 3.5 MT of Kaolin (Clay) deposits situated at Nagar Parker region of Sindh, Pakistan. This indigenous material is being used to produce ceramic products and in paper making. Now we use this mineral source to remove lead from water by adsorption. Kaolin clay can be used as an adsorbent due to its unique structure. XRF technique is employed for clay characterization. Resultants will be analyzed by UV – Vis Spectrophotometry.
Delayed Intracerebral Hematoma after Ventriculoperitoneal Shunt in the Context of Ruptured Brain AVM: Possible Underlying Mechanisms and Literature Review
Authors: Dannhoff Guillaume , Mallereau Charles-Henry , Chibbaro Salvatore , Ganau Mario , Agbo-Panzo Martial , Santin Marie des Neiges , Ollivier Irène , Pop Raoul , Proust François , Todeschi Julien
Published: July 2023

Hemorrhagic complications arising from ventricular drainage procedures are typically asymptomatic and of low volume. A particular subset of these complications known as Delayed Intracranial Hemorrhage (DICH) is however recognized for its particularly poor prognosis. We primarily aimed to identify epidemiological characteristics associated with DICH, to shed light on its occurrence and potential risk factors. To do so, we performed a retrospective analysis of a series of ten patients who presented with DICH in the context of a ruptured brain Arteriovenous Malformation (bAVM), and a systematic literature review of all DICH cases reported in the literature. Our ten patients showed delayed neurological deterioration after Ventriculoperitoneal Shunt (VPS) procedure, with a computed tomography (CT) scan revealing a DICH surrounding the ventricular catheter, distinct and away from the nidus of their previously ruptured bAVM. Four patients (40%) rapidly declined and passed away, three (30%) required surgical management and the remaining three (30%) demonstrated gradual clinical improvement with conservative management. In the literature, most patients presenting with DICH had hydrocephalus associated with neurovascular disorders (47% of cases), such as bAVM rupture in our present series. These constatations point out the significance of underlying pathologies potentially predisposing to these unusual complications.
Total Antioxidant Capacity, Total Phenolic Content and In Vitro Predicted Bioavailability of Olive Oil Fortified with Herbs and Waste By-Products, towards Sustainable Development
Authors: Kaloteraki Chrysoula , Bousdouni Panoraia , Almpounioti Kalliopi , Ouzaid Camille , Papagianni Olga , Sfikti Fotini , Dimitsa Elina , Tsami Dimitra , Sarivasilleiou Anastasia-Grammatiki , Karantonis Haralabos C. , Skalkos Dimitrios , Kandyliari Aikaterini , Koutelidakis Antonios E.
Published: July 2023

Nowadays, the high demand for healthy foods and sustainable products, has led the food industry to explore innovative food technologies, such as fortification with bioactive compounds like antioxidants and polyphenols, that may be sourced from herbs or by-products. The aim of the present study was to explore the enrichment of refined olive oils with natural bioactive compounds such as the herbs rosemary (salvia rosmarinus), basil (ocimum basil), sage (salvia officinalis), lemon balm (melissa oficinallis), st. john’s wort (hypericum perforatum), pink savory (Thymbra satureja), dittany (origanum dictamnus), and by-products such as pomace from olives, olive leaves (olea europaea tree), orange peel (citrus sinensis), lemon peel (citrus limon), pomegranate peel (punica granatum) and mandarin peel (citrus reticulate). The fortification of the refined olive oils was performed with the use of different methodologies such as Conventional maceration (CM), Incubation shaking maceration (ISM), and Ultrasound assisted maceration (UAM). Their phenolic content and antioxidant capacity were measured with Folin–Ciocalteu assay and Ferric Reducing Antioxidant Power (FRAP) assay respectively. All methods demonstrated that different parameters such as time of maceration, temperature and sample concentration, play an important role in the fortification process of the refined olive oils. The predicyed bioavailability of the antioxidant and phenolic compounds in the fortified oils was determined with in vitro digestion and ranged from 4.84% to 53.11%. Furthermore, the refined olive oils fortified with pomace, basil, st. john's wort, and pomegranate peel presented the highest antioxidant and phenolic predicted bioavailability indices during the in vitro process compared to the control refined olive oil. Finally, fortification with natural herbs or by-products can be considered an innovative method for the improvement of the nutritional value of refined olive oils.
Anti-inflammatory and Antifibrotic Potential of Longidaza in the Bleomycin-induced Pulmonary Fibrosis
Authors: Pakhomova Angelina , Pershina Olga , Bochkov Pavel , Ermakova Natalia , Pan Edgar , Sandrikina Lubov , Dagil Yulia , Kogai Lena , Grimm Wolf-Dieter , Zhukova Mariia , Avdeev Sergey
Published: July 2023

Idiopathic pulmonary fibrosis (IPF) is one of the most common forms of interstitial lung disease characterized by progressive parenchymal fibrosis and respiratory failure. In a model of bleomycin-induced pulmonary fibrosis, the antifibrotic and anti-inflammatory activity of Longidaza (bovhyaluronidase azoxymer), which contains a conjugate of the hyaluronidase enzyme with a high molecular weight synthetic carrier azoxymer bromide, was investigated. Experiments were conducted in male C57BL/6 mice. Longidaza was administered at different doses by intranasal and intramuscular routes. Histology, hematology and enzyme-linked immunosorbent assay were used in the study. The use of Longidaza reduced pulmonary fibrosis as evidenced by an improvement in histopathologic damage to the lungs, a decrease in the area of connective tissue and the levels of profibrotic factors (TGF-β1, hydroxyproline, collagen I) in lung tissue. In addition, Longidaza inhibited the inflammatory response in pulmonary fibrosis, decreased the levels of IL-6, TNF-α, hyaluronic acid in lung tissue and the recruitment of inflammatory cells into lung tissue. The highest therapeutic efficacy was observed with the use of Longidaza at doses of 120 and 1200 U/kg intramuscularly, which was superior to that of the reference drug pirfenidone axunio. The data presented in this study suggest that Longidaza is a new and promising drug for the treatment of IPF that warrants further investigation in patients with fibrotic interstitial lung disease.
The Role of Teachers in Addressing Childhood Obesity: A School-Based Approach
Authors: Snelling Anastasia , Hawkins Melissa , McClave Robin , Irvine Belson Sarah
Published: July 2023

Childhood obesity is one of the most prevalent public health challenges in the United States and although rates are declining overall, rates among children living in underserved neighborhoods are increasing. This five-year intervention project seeks to empower teachers (n=92) to invest in their own health and then to integrate nutrition concepts into core subjects’ lessons in elementary schools. The professional development sessions reflect the concepts in the Whole Child, Whole School, Whole Community model. Results indicate that teachers who attended professional development sessions were more likely to implement nutrition lessons in the classroom (r = 0.54, p<0.01) and students demonstrated a significant increase in nutrition knowledge (p < .001, df = 2, F = 9.66). Investing in school-based programs that ensure teacher well-being and professional development can yield positive benefits for both teachers and students.