bluuebunny/crossref_metadata_2025 huggingface dataset:
INVESTIGATION OF MICROCIRCULATION PECULIARITIES IN THE ZONE OF DIGESTIVE ANASTOMOSIS DURING EARLY AND DELAYED POSTOPERATIVE PERIOD AS A PREDICTOR OF ITS INSUFFICIENCY
Authors: Poroysky Sergey V. , Morozov Egor A.
Published: December 2022

The aim of the research is to evaluate the condition of blood flow in the area of digestive anastomosis in the early and delayed postoperative period in an experiment. The experiment included 30 sexually mature laboratory rabbits-males of the breed Soviet Chinchilla. The animals were done laparotomy, enterotomy, followed by the imposition of a digestive single-row nodular anastomosis "edge to edge", then the evaluation of local blood flow condition in the zone of digestive anastomosis was performed in the early (3 days) and delayed (7, 14 days) postoperative period using the method of Laser Doppler Flowmetry (LDF). The data received demonstrated a decrease of local blood flow in the early postoperative period in the area of digestive anastomosis, that forms the most vulnerable period for the development of its insufficiency. In the delayed postoperative period, there is an improvement in the indicators of local blood flow in the anastomosis zone, with an approximation of their values to the condition of the intact intestinal tract.
THE ROLE OF ECOLOGICAL FACTORS IN THE FORMATION OF INDIVIDUAL AND POPULATION HEALTH OF CHILDREN IN THE ASTRAKHAN REGION
Authors: Bashkina Olga A. , Bogdanyants Maya V. , Dzhumagaziev Anvar A. , Shmeleva Angelika Yu. , Bezrukov Timur D. , Ivanov Valeria N. , Sangina Elena G. , Erachina Svetlana A. , Minakova Galina M.
Published: December 2022

This article is the extension of our ecological (correlation) study of some environmental factors on child morbidity (0-14 years old) in Astrakhan region at 2011-2019. Due to Spearman Rank Correlation analysis we identified some classes, types and individual diseases the most sensitive to atmospheric air pollution in the Astrakhan region. There are diseases of the respiratory system, endocrine system, blood, hematopoietic organs and individual disorders associated with the immune mechanism. Summary of the article is devoted to a correlation study of the impact of adverse environmental factors on the incidence of children (0-14 years) in the Astrakhan region and the assessment of the proportion of environmentally related components in the incidence of children's population.
CARDIOVASCULAR EFFECTS OF CHEMIO- AND RADIATION THERAPY IN CANCER PATIENTS: WHAT A CARDIO-ONCOLOGIST SHOULD KNOW (PART I)
Authors: Bespalov Vladimir C. , Kirakozov Dmitry A. , Ilyukhin Oleg V.
Published: December 2022

The review presents an analysis of current literature data demonstrating the pathophysiological mechanisms of the development of cardiovascular complications of chemo- and radiation therapy in cancer patients. The undoubted successes achieved in the treatment of oncological diseases can improve survival and reduce mortality. However, there was a problem of increasing cardiovascular complications during long-term treatment, due to various toxic side effects of chemo- and radiation therapy from the cardiovascular system. For comprehensive prevention and treatment, as well as to improve the prognosis, it is necessary to understand the mechanisms and interactions of drugs underlying the interstitial curation of cancer patients. The purpose of this review is to analyze literature sources illustrating the pathophysiological mechanisms of cardiovascular toxicity in the appointment of chemotherapy and radiation therapy in clinical practice in cancer patients.
THE ROLE OF RISK ASSESSMENT IN RESECTION SURGERY FOR LIVER ECHINOCOCCOSIS
Authors: Krasnov Arkadiy O. , Anishchenko Vladimir V. , Pachgin Igor V. , Krasnov Konstantin A. , Pelts Vladislav A. , Krasnov Oleg A. , Pavlenko Vladimir V.
Published: December 2022

Resume: Introduction. Echinococcosis of the Liver with subtotal organ damage remains an urgent surgical problem. The development of surgical technologies does not stand still. In the modern scientific community, more and more publications appear that speak of good treatment results with the staged application of various surgical technologies and their combination in various options. The purpose of the study is to present and evaluate the results of treatment of operated patients with liver echinococcosis using a new diagnostic and treatment protocoL for surgicaL treatment. Materials and methods. The results of treatment of 10 patients [4 men (40%), 6 women (60%)] with widespread parasitic lesions of the liver, who underwent 26 surgical interventions for liver echinococcosis in the surgical department No. 2 on the basis of the M.A. Podgorbunsky” in the period from 2017 to 2022. The difference in the number of operations performed and actual patients is explained by the use of a staged method of surgical treatment. Criteria for inclusion in the study group: the absence of an initiaL sufficient safe LeveL of Liver functionaL reserves to perform a one-stage extensive Liver resection based on the results of a comprehensive assessment of clinical, laboratory and instrumental tests in conjunction with the use of a statistical prognostic model. Results. All patients (10/100%) from the study group underwent laparoscopic vascular isolation of the portal blood flow of the right Lobe of the Liver in order to create vicarious hypertrophy of the contralateral Lobe and increase the reserve capacity of the Liver. After objective confirmation of the effectiveness of the above surgical stage of treatment, assessment of the perioperative risk using a statistical model, aLL underwent extensive Liver resections as the next stage. In the postoperative period, 8/80% of patients had post-resection hepatic insufficiency of class A (n = 4) and B (n = 4) according to the ISGLS classification. In two patients, the clinical picture and the absence of Liver dysfunctions (synthetic, secretory, detoxification) made it possible to judge the absence of Liver failure in the postoperative period. Against the background of conservative therapy, the phenomena of Liver failure regressed. ALL patients were discharged in a satisfactory condition. Findings. Staged Laparoscopic vascular isolation of portal bLood flow is effective and safe. The use of a modern diagnostic algorithm for perioperative examination in combination with staged surgical techniques makes it possible to achieve good treatment results in a specialized surgical center.
Assessment of Bukola Saraki Administration in Kwara State of Nigeria (2003-2011)
Authors: Ogundare Yemi Daniel
Published: December 2022

Abstract

The paper examines the assessment of the Bukola Saraki Administration 2003-2011.  The administration is an act of getting things achieved through the people; it requires leadership quality, ideology, and value. The historical analysis of Kwara State administrations in the fourth republic is not complete without considering the political dynastic transfer of Olusola Saraki to a biological son Bukola Saraki in the political process of Kwara State as a governor. The objective of this paper is to assess the success and failure of the Peoples Democratic Party (PDP) in Kwara State during the Abubakar Bukola Saraki administrations. The theory employed in this paper is the Stakeholders theory, which is relevant to this work. The research methodology is a secondary source and analytical.  The findings of the paper identify the successes and limitations of PDP administrations from 2003-2011. The paper recommends democratic lifestyle leadership with transparency and accountability government to the citizen as the best set of administration to be practiced in any polity.
Perfil nutricional dos alimentos doados por bancos de alimentos públicos da região metropolitana de Belo Horizonte, Minas Gerais, Brasil
Authors: Barros Thaís , Tenuta Natalia , Teixeira Romero Alves
Published: December 2022

Foi realizada pesquisa quantitativa descritiva, de natureza exploratória, avaliando o perfil nutricional dos alimentos doados por quatro bancos de alimentos públicos da região metropolitana de Belo Horizonte, Minas Gerais, Brasil, em 2018. Os alimentos foram agrupados e classificados segundo a primeira edição do Guia alimentar para população brasileira e a classificação NOVA. A análise estatística descritiva simples demonstrou que os estoques operacionais eram compostos por 45,2% de hortaliças, 25,2% de frutas, 15,6% de cereais, raízes e tubérculos, e 14,0% pelos outros grupos, leite e derivados, leguminosas, carnes e ovos, açúcares e doces, e óleos e gorduras. Os alimentos in natura, minimamente processados e ingredientes culinários, categorizados em saudáveis, compuseram 95,5% das doações em todos os bancos de alimentos, demonstrando que estão atuando na perspectiva da segurança alimentar e nutricional e da alimentação adequada e saudável.
A arquitetura e o habitus no museu paisagem de arte contemporânea (MPAC)
Authors: Costa Robson Xavier da
Published: December 2022

O estudo das relações entre os públicos, a arquitetura e a expografia de museus paisagens de arte contemporânea (MPACs) são fundamentais para os projetos de curadoria e design de exposições nesses espaços. O objetivo deste ensaio teórico é problematizar as relações entre a arquitetura da arte e a interação com os públicos nos MPACs. Partimos dos conceitos de Habitus (Bourdieu, [1966]2007), caixa arquitetônica (Cruz Pinto, 2007) e museu ativo (Montaner, 1995), utilizando a pesquisa qualitativa com revisão bibliográfica. Concluímos que o diálogo entre a arquitetura da arte, o parque/jardim, as exposições de arte e os públicos em MPACs tem de estar permanentemente presentes, desde a concepção inicial do museu, até as modificações cotidianas por ocasião das montagens e desmontagens de exposições temporárias.
Viability and Antibacterial Activity of Bifidobacterium bifidum in Fermented Robusta Coffee for Diarrhea Treatment
Authors: Miksusanti  , Apriani Elsa Fitria , Hidayat Dimas Nur
Published: December 2022

Background: Diarrhea can be treated with probiotic bacteria such as Bifidobacterium bifidum, which decreases the intestinal environment's pH to become acidic so that pathogenic bacteria cannot thrive. Objective: To make fermented coffee that can increase the number of probiotic bacteria Bifidobacterium bifidum and has antidiarrheal activity against pathogenic bacteria Escherichia coli. Methods: Robusta coffee (20.25% and 19.75%) was fermented using Saccharomyces cerevisiae, and then the probiotic bacteria Bifidobacterium bifidum was added. Unfermented coffee was compared with the same concentration (20.25% and 19.75%) to obtain four formulas. Organoleptic panelists tested all formulas to determine the best formula for fermented and non-fermented coffee. The number of Bifidobacterium bifidum and antibacterial activity was calculated on the optimum formulation using the Total Plate Count and Disc Diffusion Method. Result: The optimum formula obtained at fermented and unfermented coffee concentration was 20,25%. The number of probiotic bacteria Bifidobacterium bifidum growing in fermented and non-fermented coffee was 7.3 x 108 ± 32.4 and 3.1 x 108 ± 30.7 (p < 0.05). The diameter of the inhibition zone of the best fermented and non-fermented coffee was 11.5 ± 0.5 mm and 8.5 ± 0.5 mm, respectively (p < 0.05). Conclusion: Fermented coffee can increase the growth of the probiotic bacteria Bifidobacterium bifidum and has strong antibacterial activity against Escherichia coli bacteria.
Samsung’s CSR in Solving Educational Issues in India
Authors: Anisah Ismail Nur Izzah
Published: December 2022

This paper discusses how corporate social responsibility could help in assisting states with global issues. The globalization which is experienced by every part of the world has created new and more complex issues. These issues sometimes cannot be solved by the state solely, demanding a global governance with the hope to cope with the issues. The existence of multinational corporations (MNC) as a new rising actor, through their corporate social responsibility (CSR) is hoping to be responsible to the society they operate. The writer argues that through the Public-Private Partnership, the CSR by MNC can help the state in solving the global issues faced by them. One of the global issues that needs the attention of the community is educational issues, especially in developing states. To strengthen the writer’s argument, this paper will raise a case study on Samsung’s CSR and their impacts on India educational issues. India is one of the states who is battling with the educational issues, and Samsung as one of the biggest MNC in India is actively assisting the government regarding the issues. The success of these CSR can be seen through the response of the Indian local government.
Factors affecting the levels and pathways of atmospheric brominated flame retardant uptake by humans in different weather conditions
Authors: Hu Peng-Tuan , Zhong Shi-Min , Liu Dong-Hai , Wang Liang , Yu Hao , Cao Zhi-Guo , Li Yi-Fan
Published: December 2022

The health risks posed by atmospheric brominated flame retardants (BFRs) have been widely studied, but there remains a lack of clarity about exposure differences between clear days and haze days. We sampled the total suspended particle (TSP) and gaseous BFRs on clear days in summer, clear days in winter, and haze days in winter in Harbin, China, to investigate the variations in the concentrations and intakes (dermal and inhalation) in the different weather conditions. The concentrations of atmospheric BFRs were highest on haze days in winter (185 pg/m3), followed by clear days in summer (158 pg/m3), and clear days in winter (79.2 pg/m3), and these concentrations were significantly correlated with the concentrations of TSP. The human intake in the different weather conditions followed the pattern of the BFR concentrations, and the human intake of atmospheric BFRs was dominated by inhalation. A comparison of the BFR levels showed that the human intake of gaseous and particulate BFRs varied in the three weather conditions and that the inhalation intake, but not the dermal intake, was influenced under high concentrations of gaseous BFRs with low molecular weight.
THE EFFECTIVENESS OF COOPERATIVE LEARNING IN DEVELOPING GRAMMAR SKILLS
Authors: Odehova Nataliia , Nevska Yuliia , Perlova Viktoriia
Published: December 2022

The article presents the results of the experimental enquiry aimed at studying the impact of cooperative learning on improving grammar skills. The research focused on two interaction modes – pair work and group work, which were compared in terms of their potential to address accuracy. The experiment was carried out in the first term of the 2020-2021 academic year (September-October). The participants included 23 third-year students of the Foreign Philology Faculty of H. S. Skovoroda Kharkiv National Pedagogical University and constituted two academic groups, with one being offered pair-work activities and the other working in small groups. The experimental study comprised three phases: pre-experiment testing, teaching, post-experiment testing. Both quantitative and qualitative methods were used. The results demonstrate the validity of the assumption about the efficacy of pair work and group work in promoting accuracy, at the same time indicating no statistically significant difference between the two modes. The presented evidence suggests that grammar instruction can clearly benefit from incorporating both pair work and group work into classroom practices, however further research might be advisable to maximize the effectiveness of these interaction patterns by refining the procedure involved and improving students’ cooperative learning skills.
NEW TECHNOLOGIES AND THEIR IMPACT ON FOREIGN LANGUAGE TEACHER PROFESSIONAL BURNOUT
Authors: Morska Liliya , Polok Krzysztof , Bukowska Małgorzata , Ladanivska Iryna
Published: December 2022

Because of the dynamic and rapid development of digital technologies, teachers are facing more than ever challenging issues related to coping with educational innovations. This situation has become ultimately evident under COVID-19 quarantine and the necessity to work remotely. Such requirements induce extra pressure on teachers, which causes excessive stress, often leading to emotional and professional burnout. In our paper, we aim to focus on the types of impact (positive or negative) of digital technologies in relation to foreign language teachers’ age and experience and the level of professional burnout. Specific emphasis is put on the study of coronavirus-related remote learning mode circumstances. To reach the research goal, a mixed method was used, engaging 140 English language teachers from 18 Polish schools, Silesia region, with a questionnaire and a semi-structured interview as the tools used in the quantitative and qualitative stages of the study. The research findings show that even though teachers are ready to integrate technologies in the classroom, they are vulnerable to technical problems which often occur during the lessons, causing the feeling of disappointment, frustration, anxiety, and lowering the efficiency of teachers’ professional performance. The implications of the study suggest that the professional support for teachers in technology use, better working conditions, and equipping language classrooms with good quality digital devices should serve as the best remedy against teacher burnout.
“Pedagogías Radicales”, una investigación sobre la enseñanza de la arquitectura
Authors: Vilaplana de Miguel Paula
Published: December 2022

ResumenEste grueso volumen de 400 páginas, editado por Beatriz Colomina, Ignacio G. Galán, Anna-María Meister y Evangelos Kotsioris y publicado por MIT Press este mismo año, recoge, a través de una multiplicidad de autores y casos de estudio repartidos por todo el planeta, un catálogo polifacético de experiencias pedagógicas y experimentos educativos que exploran territorios conocidos y desconocidos en la enseñanza de la arquitectura y la concepción de los currículos académicos entre 1933 y 1987.AbstractThe 400-page volume, edited by Beatriz Colomina, Ignacio G. Galán, Anna-María Meister and Evangelos Kotsioris and published by MIT Press this year, brings together, through a multiplicity of authors and case studies from all over the planet, a multifaceted catalogue of pedagogical experiences and educational experiments that explore known and unknown territories in the teaching of architecture and the conception of academic curricula between 1933 and 1987.
Women entrepreneurship: A sentiment analysis
Authors: Rusydiana Aam Slamet , Izza Nadia Nurul
Published: December 2022

Purpose – This study aims to determine the sentiment towards women's entrepreneurship development in the last 32 years, from 1987 to 2019Methodology – The method used is descriptive statistical analysis combined with meta-analysis and sentiment from secondary data in metadata from 98 Scopus indexed publications, then processed using Microsoft Excel 2019 and SentiStrength software.Findings – The sentiment analysis results show that the expert opinions on the development of women's entrepreneurship are diverse, with positive sentiment at 30.6%, negative sentiment at 30.6%, and neutral sentiment at 38.8%. Based on the study results, it was found that there had been a rise in the study on the topic of developing women's entrepreneurship in the scholarly literature. Implications – These results can be used as illustrations to provide education and literacy about existing barriers to women's entrepreneurship. A strong commitment from a variety of stakeholders, including interested parties such as policymakers and the government, hoped to play a critical role in supporting and strengthening the women entrepreneurship ecosystem to advance economic empowerment by advancing innovation in tandem with the advancement of digitalization in the form of digital technology, improving the education system and employment practices can maximize the potential of female entrepreneurs, resulting in positive outcomes such as job creation and increased welfare, as well as assisting the United Nations in implementing the Sustainable Development Goals (SDGs).Originality – There are no papers discussing the evolution of global views of interest in women's entrepreneurship research using the sentiment method. Therefore, this paper is among the first.
Emerging from the COVID-19 Pandemic Aviation Recovery, Challenges and Opportunities
Authors: Dube Kaitano
Published: December 2022

This exploratory study examined the impacts of COVID-19 and emerging challenges and opportunities from aviation recovery. Using archival and secondary data analysis, the study found that there are several challenges to aviation recovery chief among them are labour challenges and extreme weather events, which have been responsible for traffic disruptions in major aviation markets such as Europe and the USA. Other emerging challenges include high debt, inflation, interest rates, fuel, cost of labour, and general operational costs. The study recommends several interventions to address the sector’s challenges, including adopting risk disaster preparedness and management to foster sustainability.
Anxiety Analysis of Students Taking Distance Learning in Mathematics Learning in Junior High Schools
Authors: Sara Joanna Ayuni
Published: December 2022

Mathematics anxiety is a psychological condition of students in the learning process of mathematics. This study aims to describe students' learning anxiety in distance learning in mathematics learning. The method used in this study is a literature review method of books and literature as data. The method used in this study is a literature review method of books and literature as data. In addition, this research was strengthened by collecting data obtained through distributing questionnaires consisting of 17 statements in order to determine the interpretation of mathematics learning anxiety experienced by students in distance learning. Questionnaires were given to students at SMPTK Pelita Hati Denpasar in the 2021/2022 academic year as many as 27 respondents. The results of this study indicate that students experience learning anxiety in online mathematics learning. Forms of anxiety when participating in distance learning in mathematics learning that arise from students in the form of feelings of fear, worry, lack of confidence, anxiety, faster heart beats and even trying to avoid learning.
Chromatic Number of Amalgamation of Wheel Graph-Star Graph and Amalgamation of Wheel Graph-Sikel Graph
Authors: Kuswardi Yemi , Almira Luthfi , Nurussakbana Novita , Pinilih Anggoro Canggih
Published: December 2022

A graph denoted by  is a pair of  where  is a non-empty set of vertices in G, and E is a set of edges in G. In graph theory, there are various types of graphs including star graphs, cycle graph, and wheel graph. Graph operations on two or more types of graphs can produce new graphs. Amalgamation is one of the operations on graphs. Suppose  and  are two connected graphs, amalgamating the vertices of graph 1 and graph 2 by joining vertices  and vertices   denoted by  is the graph obtained by joins vertex  of graph  and vertex  of graph  into one vertex , where  is the common vertex of the graph resulting from , while amalgamating the edges of graph  and graph  by joining edges  and edge , denoted by  are graphs obtained by combining edge of graph 1 and edge of graph 2 into one edge g, where g is common side of graph of (𝐺1,𝐺2;𝑒,𝑓). Vertex coloring is one of the fastest-growing topics in graphs. The coloring of the vertices, that is, assigning a color to each vertex of the graph so that each neighboring vertex has a different color. The minimum number of colors used to color the vertices of a graph is called the chromatic number. In this article, we discuss the chromatic number in the amalgamated graph of wheel graph and star graph and the chromatic number on the amalgamation of wheel graph and cycle graph. The results obtained are as follows: (1) the chromatic number of the amalgamated graph of the wheel graph () and the star graph () for n even is 3 and for n odd is 4, (2) the chromatic number of the graph resulting from the operation amalgamation of the wheel graph () and the cycle graph () for n even is 3 and for  odd is 4.
Review of the notions of distributed ledger technologies and digital assets for harmonization of their joint use
Authors: Vlasov A. V.
Published: December 2022

Objective:to analyze the transforming socio-economic relations of the new “digital normality”, to which end the task is solved of bringing into line the terminology used in business turnover between various participants in the digital assets market, in the practical financial activities of economic entities arising in a specific territory, in a certain legal field, and contained in the recommendatory technical documentation (standards).

Methods:the article uses systematic and analytical approaches, logical and comparative methods.

Results:despite the active use of distributed ledger technologies, theory and practice are currently characterized by a large number of legal and business definitions describing the organization of business processes in this area. Based on the analysis of scientific literature, the meaning of various terms of the digital economy was studied. In the course of studying technical terminology, such concepts as a distributed ledger, network nodes, blockchain, etc. were defined. The analysis of financial and economic terms is based on fintech definitions, such as digital asset, cryptocurrency, digital currency, digital financial asset, token, etc. The terms of the digital economy are considered from the perspective of so-called tokenomics, including such as token ecosystem, DLT user, DLT platform, decentralized application, etc.

Scientific novelty: the terminology obtained was structured as a theoretical basis with a specification for the digital asset market and use in financial market reform.

Practical significance: this review has been prepared: 1) to systematically familiarize the professional community with existing trends; 2) to harmonize socio-economic relations by developing common local recommendations (standards); 3) to develop the market for digital assets produced using distributed ledger technologies through understanding basic concepts.
GATA2 as an outcome signature: promoting bladder cancer migration and inhibiting PD-L1 expression
Authors: Sun Siqing
Published: December 2022

Background

Embryonic development is regulated by stem cells, and epithelial-to-mesenchymal transition (EMT) is associated with cell stemness ; nevertheless, the EMT regulation by embryonic development-related genes has not been studied. Immune checkpoints exert an essential effect in tumor treatment ; however, their regulatory mechanisms have not been fully elucidated.

Methods

We obtained clinicopathological and transcriptome data from The Cancer Genome Atlas. Embryonic development- associated genes were obtained from The Human Gene Database. We identified genes using univariate Cox regression analysis and identified various subtypes using consensus clustering analysis. Immunoassays were performed using the CIBERSORT package and Estimation of Stromal and Immune cells in the Malignant Tumor tissues using an expression data algorithm. The least absolute shrinkage and selection operator algorithm and multivariate Cox regression analysis were adopted to generate the prognostic model. We used the OCLR and TIDE algorithms. We conducted functional experiments.

Results

Twenty-two embryonic development-associated genes were risk factors for bladder cancer, and their expression levels significantly correlated with the TNM stage. We assessed the extent of immune infiltration, regulation of immune checkpoints, and responses to immune checkpoint blockade based on these genes. These risk genes were associated with EMT and modulated immune checkpoints. Cellular experiments demonstrated that EVC2 and GATA2 drive BLCA migration. GATA2 regulated the PD-L1 expression.

Conclusion

We identified three critical genes: RUNX2, GATA2 and EVC2. These three genes are related to EMT and immune cell infiltration and are independent prognostic elements for BLCA.
Potential effects of POLR2H and DYNC1I2 on the immunity and prognosis of neuroblastoma
Authors: Ma Yingxuan , Lu Li , Li Zhi , Xu Weijue , Liu Jiangbin , Guo Ting , Wu Yibo , Tan Kezhe , Wu Wei , Zheng Lulu , Fan Feilong , Gong Zhenhua
Published: December 2022

Objective
The present study utilized bioinformatics techniques and data from the GEO, TARGET, and ArrayExpress databases to compare gene expression in INSS4 and INSS1 neuroblastomas (NBs), thereby identifying metabolites with different levels of expression and predicting the prognosis of patients with NB.
METHODS
Genes of patients with INSS4 and INSS1 NBs from the GEO database were screened, with those having ཛྷlog2fold change (FC)ཛྷ>3 and adjusted P < 0.05 defined as being differentially expressed. These differentially expressed genes (DEGs) were screened to obtain clinical data and RNA sequence datasets from NB patients in the TARGET database. Univariate Cox proportional hazards regression analysis identified prognosis-related genes, which were incorporated into a prognosis model. Based on median risk scores, these patients were divided into high and low-risk groups. Their survival rates were compared, and ROC curves were used to analyze predictive values for NB. NB patients were also divided into two clusters by consensus clustering based on levels of POLR2H and DYNC1I2 expression. Immune infiltration analyses were performed using GSEA, ESTIMATE, CIBERSORT, and ssGSEA. Tumor tissue of 17 NB patients was used for experimental verification and their survival was compared.
Result
Analysis of three datasets identified 62 up-regulated genes and 163 down-regulated genes. The prognostic model predicted that the areas under the 3-year and 5-year survival curves were 0.786 and 0.817, respectively. Levels of expression of POLR2H and DYNC1I2 accounted for the highest percentage of risk scores and were included in follow-up analysis. Samples were consistently clustered according to their expression matrix. POLR2H was more highly expressed in cluster 2, whereas DYNC1I2 was more highly expressed in cluster 1. The survival rate of cluster 1 was significantly higher than that of cluster 2. Experimental verification in 17 NB patients showed that these patients could also be divided into two groups, which differed significantly in mortality hazard ratio (HR 9.37 P < 0.05).
Conclusion
The expression of POLR2H and DYNC1I2 affects the immune microenvironment of NB and can affect patient prognosis. These factors can be used to refine clinical groupings, guide personalized treatment, and suggest new methods for the diagnosis and treatment of NB.
Uncertainty quantification in mechanistic epidemic models via cross-entropy approximate Bayesian computation
Authors: Cunha Americo , Barton David A W , Ritto Thiago G
Published: December 2022

This paper proposes a data-driven machine learning framework for parameter estimation and uncertainty quantification in epidemic models based on two key ingredients: (i) prior parameters learning via the cross-entropy method and (ii) update of the model calibration and uncertainty propagation through approximate Bayesian computation. The effectiveness of the new methodology is illustrated with the aid of actual data from COVID-19 epidemic at Rio de Janeiro city in Brazil, employing an ordinary differential equation based model with a generalized SEIR-type mechanistic structure that includes time-dependent transmission rate, asymptomatics, and hospitalizations. A minimization problem with two cost terms (number of hospitalizations and deaths) is formulated, and twelve parameters are identified. The calibrated model provides a consistent description of the available data, able to extrapolate forecasts over a few weeks, which makes the proposed methodology very appealing for use in the context of real-time epidemic modeling.
Surgical treatment of carpometacarpal thumb arthritis with trapeziectomy and intra-tendon (FCR) suspension with one-loop APL: comparative cohort study.
Authors: PASSIATORE MARCO , TACCARDO GIUSEPPE , CILLI VITALE , ROVERE GIUSEPPE , LIUZZA FRANCESCO , PANNUTO LUCIA , DE VITIS ROCCO
Published: December 2022

Background:
One of the currents choices of treatment for Trapeziometacarpal (TMC) joint arthritis is trapeziectomy with ligament reconstruction and tendon interposition arthroplasty. The original Ceruso’s technique consists in complete trapezial excision and abductor pollicis longus (APL) tendon suspension. APL tendon is tied to the flexor carpi radialis (FCR) tendon with two loops, one around it and one inside, and then used as interposition tissue. The purpose of the present study was to compare two different techniques of trapeziectomy with ligament reconstruction and tendon interposition arthroplasty using the Abductor Pollicis Longus (APL) tendon, which is only Once Looped Around (OLA) versus Once Looped Inside (OLI) the Flexor Carpi Radialis (FCR) tendon.
Methods
The present retrospective one-center study (Level of evidence: III) has been conducted on sixty-seven patients aged more than 55 years (33 OLI, 35 OLA), assessing clinical outcomes at least 2 years follow-up. The outcomes were to assess and compare surgical outcomes comparing the two groups, in terms of subjective and objective evaluation for both groups at the last follow-up (primary outcome), and at the intermediate follow-ups (three and six months). Complications were also assessed.
Results
The authors found an improvement in pain, range of motion, and function, with equivalent results with both techniques. None subsidence was observed. FCR tendinitis was significantly reduced with OLI, as well as the need of post-operative physiotherapy.
Conclusions
The one-loop technique allows for reduced surgical exposure, providing excellent suspension and clinical outcomes. Intra FCR loop should be preferred to improve post-surgical recovery.
Home confinement's impact on myopia control by using orthokeratology in school-aged children
Authors: Zhang Boyuan , Liao Hongfei , Xiong Fen , Mao Tian , Wu Lili , Li Yue , Xiong Chao
Published: December 2022

Background： Home confinement during the epidemic has a significant impact on the lifestyle and behavior of school-aged children, who have exhibited an increase in the prevalence and development of myopia. Our research will look at how home confinement affects the effectiveness of orthokeratology in controlling myopia in school-aged children.
Method: Data on axial length were gathered from school-aged children who had received orthokeratology before the outbreak, with phone follow-up visits to these patients to collect AL data after the epidemic. The entire data were separated into subgroups based on gender, age, and initial refraction, and the AL change for each period was calculated using the formula defined in our study. Finally, the acquired data will be examined using various statistical approaches, and the ideas of slow, moderate, and rapid myopia progression will be applied to our study.
Result: A total of 258 study subjects met the requirements to be included in the study. We discovered that the fraction of rapid myopia growth increased during the epidemic and decreased afterward in each group. In addition, the Wilcoxon signed-rank test between the AL changes before and during the epidemic was found to be statistically significant in 171 subjects in the overall data. (P=0.041) In the high age group, the AL change before and during the epidemic、(P=0.033) the AL change before and after the epidemic (P=0.023) were found to be statistically significant. The AL change before and during the epidemic (P=0.035) was shown to be statistically significant in the moderate myopia group. Finally, we did not find statistically significant results for other groups.
Conclusion: Home confinement does negatively affect myopia control with orthokeratology, and older children (13-17 years) were more likely to be affected than younger children (8-12 years), and there was no evidence to support this effect subsided even after the home confinement. Children with initial refraction of -3.25D to -5.0D were more susceptible than those with initial refraction of -0.5D to -3.0D.
Patterns of coexistence between two mesocarnivores in presence of anthropogenic disturbances in Western Himalaya
Authors: Bandyopadhyay Meghna , Biswas Suvankar , Dasgupta Tryambak , Krishnamurthy Ramesh
Published: December 2022

Species' coexistence depends on species-specific resource utilization in a given habitat. Human disturbances in this context can constrain the realized niche by altering their community dynamics. In this study, we considered Western Himalaya as a case study to test the hypothesis that human disturbances influence mesocarnivore coexistence patterns. We regarded red fox and leopard cat as the focal species and assessed the coexistence patterns in low and high human disturbance areas in three dimensions: spatial, temporal and dietary habit. We used camera trap detections and mitochondrial DNA-based species identification of faecal samples. We used generalized linear mixed-effect modelling (GLMM), activity overlap, Levin’s niche breadth and Pianka’s overlap index to capture the spatial, temporal and dietary interactions respectively. We found that red fox and leopard cat coexisted by spatial segregation in low human disturbance area, whereas dietary segregation was the means of coexistence in high human disturbance area. We observed a broader dietary breadth for red fox and a narrower for leopard cat in high human disturbance area. The altered coexistence pattern due to differential human disturbances indicates intensive anthropogenic activities adjacent to natural forests. It can link to increased opportunities for shared spaces between mesocarnivores and humans, leading to future disease spread and conflicts. Our study contributes to scant ecological knowledge of these mesocarnivores and adds to our understanding of community dynamics in human-altered ecosystems. The study elucidates the need for long-term monitoring of wildlife inhabiting interface areas to ensure human and wildlife coexistence.
Driving factors of NOX emission reduction in China's power industry: Based on LMDI decomposition model
Authors: Guo Sen , Liu Guolei , Liu Shixuan
Published: December 2022

In this paper, starting from the synergistic effect of carbon dioxide emission reduction on nitrogen oxides emission reduction in the power industry, the "bottom-up" emission factor method was used to measure the emission of nitrogen oxides and carbon dioxide generated by the power production activities of the Chinese power industry from 2011 to 2019. Then, the contributions of nine factors to nitrogen oxide emission reduction in China's power industry were identified using the Kaya identity and Logistic Mean Divided Index (LMDI) decomposition methods. The research results show that: (1) there is a significant synergistic emission reduction effect between carbon dioxide emission reduction and nitrogen oxide emission reduction; (2) the factors that inhibit the growth of nitrogen oxide emissions reduction in the power industry are roughly energy structure and economic development factors; (3) the main factors that promote the reduction of nitrogen oxide emissions from the power industry are energy intensity, power production structure and the power generation intensity factors. Based on the results, several suggestions are proposed, which are the power industry should adjust its structure, improve energy intensity, focus on applying low-nitrogen combustion technology, and improve the air pollutant emission information disclosure system to reduce nitrogen oxide emissions.
People with higher autistic traits show stronger binding for color–shape associations
Authors: Chen Na , Watanabe Katsumi , Spence Charles , Wada Makoto
Published: December 2022

Non-synesthetes exhibit a tendency to associate specific shapes with particular colors (i.e., circle–red, triangle–yellow, and square–blue). Such color–shape associations (CSAs) could potentially affect the feature binding of colors and shapes, thus resulting in people reporting more binding errors in the case of incongruent, rather than congruent, colored-shape pairs. Individuals with autism spectrum disorder (ASD) exhibit atypical sensory processing and impaired multisensory integration. Here, we examined whether autistic traits (Autism-Spectrum Quotient; AQ) influence the strength of color–shape associations, as evidenced by the occurrence of binding errors. Participants took part in an experiment designed to reveal binding errors induced by incongruent and congruent colored-shape pairs, and completed the AQ–50 Japanese version. The results revealed a significant correlation between AQ scores and occurrence of binding errors when participants were presented with the circle–red and triangle–yellow CSAs: That is, individuals with higher autistic traits tend to make more binding errors in incongruent minus congruent colored-shape pairs, indicating a stronger binding of circle–red and triangle–yellow associations. These results therefore suggest that autistic traits play a role in forming color–shape associations, shedding light on the nature of both color–shape associations and autistic perception.
Mental Health Outcomes Before Psychotropic Medications: A Retrospective Case Series of State Hospital Records from 1945-1954
Authors: Chapleau Ann Marie , Harrison Jennifer , Love Stephen , Sherman David Steven
Published: December 2022

Background: Current outcomes for mental illness are widely regarded as poor. Since the introduction of psychotropic medications in the mid 1950's, previous psychosocial practices were minimized in favor of medication focused treatment. The majority of large U.S. state hospitals have closed with records destroyed or in storage, inaccessible to researchers. This creates barriers to studying and comparing outcomes before and after this shift in treatment practices.
Aims: The study aim was to examine discharge outcomes in relation to length of stay and diagnosis in one U.S. state hospital.
Methods: This case series study examined 5,618 medical records of participants admitted from 1945-1954, the decade prior to adoption of psychotropic medications.
Results: Of the 3332 individuals who left the facility, over half (59.87%) of first episode hospitalizations were discharged within one year, and only 16.95% were hospitalized for more than five years. 46.17% of all admissions were discharged from hospital alive with no readmission. The most common diagnoses included schizophrenia, other forms of psychosis, and alcoholism. In the decade before the introduction of psychotropic medications, participants were often admitted for a single episode and returned to their homes within several years.
Conclusions: This data challenges the erroneous assumption that prior to the introduction of psychotropic medications, participants were routinely hospitalized for years or decades and did not improve, never returning home.
To molt or not to molt: The dilemma of acquiring sexual maturity while losing durability and dispersal ability in Phorytocarpais fimetorum mites (Acari; Gamasida; Parasitidae)
Authors: Yasui Yukio
Published: December 2022

Dispersal from birthplace is an effective strategy to cope with unpredictable environmental change. In many animals, dispersal is carried out prior to mating and reproduction to avoid inbreeding. However, this also means that the dispersers must find mates in the new habitat. Phorytocarpais fimetorum (Acari; Parasitidae) (= former name Parasitus fimetorum) is a free-living predatory mite inhabiting animal dung and manure. In such ephemeral habitats, the mites quickly develop from egg to deutonymph as the environmentally tolerant, dispersal stage. After dispersal to new habitats utilizing dung beetles as phoretic hosts, deutonymphs have to decide whether to molt to adulthood by losing their tolerance and migration ability or not to molt and continue dispersal. Here, using molt-suppressing deutonymphs that were obtained under isolated conditions, I investigated whether food conditions (amount of rearing medium bearing nematodes as prey) and encounters with conspecifics stimulate their molting. A drastic increase in food resources induced molting in both sexes, but the responses to the pairing treatment were different between sexes. Whereas female deutonymphs molted at the encounter with males regardless of whether they were deutonymphs or adults, molting of male deutonymphs was induced only at the pairing with female deutonymphs (not adult females). Because adult females are usually nonvirgin and have already started oviposition, the males seemed to discriminate against them. The decision about molting is understandable as a male mate choice, which is adaptive to the limited mating opportunities in ephemeral environments.
miRNA Expression Profile in Pediatric Pineal Pure Germinomas
Authors: Fakhry Mona , Elayadi Moatasem , Elzayat Mariam , Samir Omar , Maher Eslam , Taha Hala , El-Beltagy Mohamed , Refaat Amal , Zamzam Manal , Abdelbaki Mohamed S , Sayed Ahmed , Kieran Mark , Elhaddad Alaa
Published: December 2022

Purpose
Pure germinomas account for 40% of pineal tumors and are characterized by the lack of appreciable tumor markers, thus requiring a tumor biopsy for diagnosis. MicroRNAs (miRNA) have emerged as potential non-invasive biomarkers for germ cell tumors and may facilitate the non-invasive diagnosis of pure pineal germinomas.
Methods
A retrospective chart review was performed of all patients treated at Children’s Cancer Hospital Egypt diagnosed with a pineal region tumor between June 2013 and March 2021 for whom a research blood sample was available. Plasma samples were profiled for miRNA expression and DESeq2 was used to compare between pure germinoma and other tumor types. Differentially expressed miRNAs were identified. The area under the curve of the receiver operating characteristic curve was constructed to evaluate diagnostic performance.
Results
Samples from 39 pediatric patients were available including 12 pure germinomas and 27 pineal region tumors of other pathologies, including pineal origin tumors [n = 17; pineoblastoma (n = 13), and pineal parenchymal tumors of intermediate differentiation (n = 4)], and others [n = 10; low grade glioma (n = 6) and atypical teratoid rhabdoid tumor (n = 4)]. Using an adjusted p value < 0.05, three miRNAs showed differential expression (miR-143-3p, miR-320c, miR-320d; adjusted p = 0.0058, p = 0.0478 and p = 0.0366, respectively), and good discriminatory power between the two groups (AUC 90.7%, p < 0.001) with a sensitivity of 25% and a specificity of 100%.
Conclusion
Our results demonstrated the potential of a three-plasma miRNA signature to non-invasively identify pineal body pure germinomas which may allow selected patients to avoid the potential surgical complications.