bluuebunny/crossref_metadata_2025 huggingface dataset:
A dobra do papel da dança na relação de estar com a criança
Authors: Zelenski Alves Juliana , Carolina Petreca Paula
Published: July 2024

O presente texto apresenta uma conversa (in)formal, uma entrevista sensível e poética com a pesquisadora Uxa Xavier sobre a trajetória da artista-docente da dança na infância. A abordagem desta conversa passa também pelas problemáticas vividas durante a pandemia nas circunstâncias e as estratégias utilizadas para a criação do projeto daquele momento. A entrevista foi conduzida por pesquisadora ________ e _______ e foi realizada em formato online, integrando a série de entrevistas produzida pelo Ladeira a Bausch - Podcast sobre Dança publicado nas plataformas de podcast em 1º de julho de 2021. O diálogo original foi transcrito e é aqui apresentado de modo a documentar e levantar perspectivas da Dança na infância a partir da experiência da artista-docente entrevistada em como a prática pedagógica de estar com as crianças permeia a criação em um ambiente frutífero para a imaginação.
O Inferno, de Henri-Georges Clouzot
Authors: Pereira de Souza Fabiano , Loguercio Cánepa Laura
Published: July 2024

O filme inacabado O inferno (L'enfer, França, Henri-Georges Clouzot,1964), e o documentário O inferno de Henri-Georges Clouzot (L'enfer d'Henri-Georges Clouzot, França, Serge Bromberg e Ruxandra Medrea, 2009) são nossos objetos de análise neste artigo, no qual examinamos estratégias de montagem cinematográfica por meio de sobreposição de imagens. Inspiradas na arte cinética e no cinema de vanguarda da década de 1920, as imagens mais marcantes do filme de Clouzot representam um indício experimental de como montar imagens em sobreposição pela perspectiva dos anos 1950, e foram objeto de reflexão no documentário de 2009, que buscou compreender o trágico processo criativo da obra. A partir dos dos relatos da equipe de Clouzot, de críticas e da análise prévia da pesquisadora Marion Schmid sobre o documentário, os objetivos deste artigo são destacar as estratégias de montagem como contribuição artística de viés experimental da obra inacabada de Clouzot, perceber seus reflexos na sofisticada narrativa de Bromberg e Medrea, além de comentar a importância do filme de Clouzot para a história da montagem cinematográfica.
A poética pictórica de Charles Baudelaire
Authors: Michelli S. Oliveira Juliana , Beccari Marcos Namba
Published: July 2024

Ao retratar a vida moderna por meio da prosa poética, Charles Baudelaire encontra na pintura um de seus aliados para a criação de cenas e narrativas. Interrogando as interfaces entre a literatura, a pintura e a sociedade em Le Spleen de Paris, este artigo se propõe a estudar os recursos presentes nos poemas “Le gâteau”, “Les yeux des pauvres”, “Le joujou des pauvres” e “Le vieux saltimbanque”, enfatizando a ambivalência que caracteriza a modernidade baudelairiana. Para tanto, após revisar a importância da pintura no itinerário do poeta e a inovação estilística da obra estudada, desenvolve-se um comentário sobre os poemas elencados. Dessa análise, sugere-se que Le Spleen de Paris constitui tanto uma experimentação estética quanto uma reelaboração poética e ambivalente da realidade.
Biomechanical analysis of spinal cord injury during scoliosis correction surgery
Authors: Wang Haimei , Zhang Chunyu , Wang Yongqiang , Zeng Yan , Chen Songhao , Su Xingyu , Li Weishi , Yu Miao , Chen Duanduan
Published: July 2024

Introduction: Surgical correction is a common treatment for severe scoliosis. Due to the significant spinal deformation that occurs with this condition, spinal cord injuries during corrective surgery can occur, sometimes leading to paralysis.

Methods: Such events are associated with biomechanical changes in the spinal cord during surgery, however, their underlying mechanisms are not well understood. Six patient-specific cases of scoliosis either with or without spinal complications were examined. Finite element analyses (FEA) were performed to assess the dynamic changes and stress distribution of spinal cords after surgical correction. The FEA method is a numerical technique that simplifies problem solving by replacing complex problem solving with simplified numerical computations.

Results: In four patients with poor prognosis, there was a concentration of stress in the spinal cord. The predicted spinal cord injury areas in this study were consistent with the clinical manifestations of the patients. In two patients with good prognosis, the stress distribution in the spinal cord models was uniform, and they showed no abnormal clinical manifestations postoperatively.

Discussion: This study identified a potential biomechanical mechanism of spinal cord injury caused by surgical correction of scoliosis. Numerical prediction of postoperative spinal cord stress distribution might improve surgical planning and avoid complications.
Utilizing nutrient type compounds as anti-bacterial compounds: arginine and cysteine inhibit Salmonella survival in egg white
Authors: Ben-Porat Nir , Ohayon Amital , Rosenberg Tali , Musa Abdulafiz , Petersen Erik , Mills Erez
Published: July 2024

Because of growing levels of antibiotic resistance, new methods to combat bacteria are needed. We hypothesized that because bacteria evolved to survive in specific environments, the addition of compounds, including nutrient type compounds, to an environment, might result in a modification of that environment that will disrupt bacterial growth or in maladaptive bacterial behavior, i.e., gene expression. As a proof of concept, we focused on the egg white environment and the pathogen Salmonella. Despite egg white’s antibacterial nature, Salmonella is able to survive and grow in egg white, and this ability of Salmonella leads to infection of chicks and humans. Here, the 20 L-amino-acids were screened for their ability to affect the growth of Salmonella in egg white. L-arginine and L-cysteine were found to reduce growth in egg white in physiologically relevant concentrations. To determine the mechanism behind L-arginine inhibition TnSeq was utilized. TnSeq identified many Salmonella genes required for survival in egg white including genes required for iron import, biotin synthesis, stress responses, cell integrity, and DNA repair. However, a comparison of Salmonella in egg white with and without L-arginine identified only a few differences in the frequency of transposon insertions, including the possible contribution of perturbations in the cell envelope to the inhibition mechanism. Finally, both D-arginine and D-cysteine were found to inhibit Salmonella in egg white. This implied that the effect of arginine and cysteine in egg white is chemical rather than biological, likely on the egg white environment or on the bacterial outer membrane. To conclude, these results show that this approach of addition of compounds, including nutrient type compounds, to an environment can be used to limit bacterial growth. Importantly, these compounds have no inherent anti-bacterial properties, are used as nutrients by animals and bacteria, and only become anti-bacterial in a specific environmental context. Future research screening for the effects of compounds in relevant environments might uncover new ways to reduce pathogen levels in the poultry industry and beyond.
Prolonged Impella 5.0/5.5 support within different pathways of care for cardiogenic shock: the experience of a referral center
Authors: Pieri Marina , Ortalda Alessandro , Altizio Savino , Bertoglio Luca , Nardelli Pasquale , Fominskiy Evgeny , Lapenna Elisabetta , Ajello Silvia , Scandroglio Anna Mara
Published: July 2024

Aims

Impella 5.0 and 5.5 are promising low-invasive left ventricle (LV) temporary mechanical circulatory supports (tMCS) for cardiogenic shock due to LV mechanical unloading and are paired with powerful hemodynamic support. This study aimed to analyze data and destinies of patients supported with Impella 5.0/5.5 at a national referral center for cardiogenic shock and to assess the parameters associated with myocardial recovery and successful weaning.

Methods

A single-center observational study was conducted on all patients treated with Impella 5.0 or 5.5 from March 2018 to July 2023.

Results

A total of 59 patients underwent Impella 5.0/5.5 implantation due to profound cardiogenic shock, with acute myocardial infarction being the most frequent cause of shock (42 patients, 71%). The median duration of Impella support was 13 days (maximum duration of 52 days). Axillary cannulation was feasible in almost all patients, and 36% were mobilized during support. A total of 44 patients (75%) survived to the next therapy/recovery: 21 patients experienced recovery and 15 and 8 were bridged to long-term LVAD and heart transplantation, respectively. The global survival rate was 66%. The predictors of native heart recovery at multivariate analysis were the number of days on tMCS before upgrade to Impella 5.0/5.5 [hazard ratio (HR) 0.68 (0.51–9) p = 0.0068] and improvement of LVEF within the first 7–10 days of support [HR 4.72 (1.34–16.7), p = 0.016].

Conclusions

Transcatheter systems such as Impella 5.0/5.5 revolutionized the field of tMCS. Myocardial recovery is the primary clinical target. Its prognostication and promotion are key to ensure the most proficuous course for each patient from cardiogenic shock to long-term event-free survival.
Efficient enhancement of low-rank tensor completion via thin QR decomposition
Authors: Wu Yan , Jin Yunzhi
Published: July 2024

Low-rank tensor completion (LRTC), which aims to complete missing entries from tensors with partially observed terms by utilizing the low-rank structure of tensors, has been widely used in various real-world issues. The core tensor nuclear norm minimization (CTNM) method based on Tucker decomposition is one of common LRTC methods. However, the CTNM methods based on Tucker decomposition often have a large computing cost due to the fact that the general factor matrix solving technique involves multiple singular value decompositions (SVDs) in each loop. To address this problem, this article enhances the method and proposes an effective CTNM method based on thin QR decomposition (CTNM-QR) with lower computing complexity. The proposed method extends the CTNM by introducing tensor versions of the auxiliary variables instead of matrices, while using the thin QR decomposition to solve the factor matrix rather than the SVD, which can save the computational complexity and improve the tensor completion accuracy. In addition, the CTNM-QR method's convergence and complexity are analyzed further. Numerous experiments in synthetic data, real color images, and brain MRI data at different missing rates demonstrate that the proposed method not only outperforms in terms of completion accuracy and visualization, but also conducts more efficiently than most state-of-the-art LRTC methods.
Changes in body weight and composition, metabolic parameters, and quality of life in patients with type 2 diabetes treated with subcutaneous semaglutide in real-world clinical practice
Authors: Pantanetti Paola , Cangelosi Giovanni , Alberti Sara , Di Marco Sandra , Michetti Grazia , Cerasoli Gianluca , Di Giacinti Marco , Coacci Silvia , Francucci Nadia , Petrelli Fabio , Ambrosio Giuseppe , Grinta Roberto
Published: July 2024

Subcutaneous once-weekly (ow) semaglutide is a recent treatment option for type 2 diabetes (T2D) and obesity, but real-world data on weight loss and associated changes in body composition, nutrients intake, and quality of life are still scarce. This observational, prospective clinical study involved all T2D patients starting ow semaglutide according to routine care between December 2021 and February 2022. Clinical information was collected after 6 months (T6) and 12 months (T12) from semaglutide initiation (T0). Bioelectrical Impedance Analysis (BIA) was performed to measure changes in body composition. Diabetes Treatment Satisfaction Questionnaire (DTSQ) and the 36 – items Short Form Health Survey (SF-36) were administered as patient-reported outcomes (PROs). Changes in continuous endpoints (weight, body composition, nutrients intake, other clinical parameters, and PROs) were assessed using mixed models for repeated measurements. Overall, 90 patients (age 63.0 ± 10.0 years; diabetes duration 7.6 ± 5.9 years; 58.9% men; HbA1c 7.7 ± 1.1%; weight 95.4 ± 19.4 Kg, BMI 34.6 ± 6.4 Kg/m2; 36.7% naïve to diabetes treatment, 43.3% on metformin, 10.0% on dual oral therapy, and 10.0% treated with schemes including insulin) were included in the study. After 6 months from semaglutide initiation, body weight significantly decrease by -4.69 Kg (95%CI -6.19;-3.19) (primary endpoint). After 12 months, body weight was further reduced (-5.38 Kg; 95%CI -7.79;-2.97). At BIA, fat mass was significantly reduced by 2.1 Kg after 6 months but only slightly reduced after 12 months vs. baseline; lean mass was also significantly reduced by over 3 Kg both at 6 and 12 months. Intake of all nutrients declined in the first 6 months of therapy, although only lipids reduction reached the statistical significance (-6.73 g; p=0.02). Statistically significant improvements in BMI, waist circumference, glycemic control, blood pressure and lipid profile were documented. Satisfaction with treatment (DTSQ questionnaire) and mental health (MCS score of SF-36 questionnaire) significantly increased during the follow-up. The study documented real-world benefits of semaglutide for treating obesity in T2D subjects, with important changes on clinical and patient-reported outcomes. Loss of lean mass associated with weight loss warrants attention; parallel strategies to preserve skeletal muscle and improve physical function, i.e. nutritional education and structured exercise, are of great importance.
Tele-rehabilitation for Type II diabetics with heart failure with preserved ejection fraction
Authors: Yuan Minjie , Xu Haimin , Zhao Dongqi , Shi Dongdong , Su Li , Zhu Huifang , Lu Shengdi , Wei Junbo
Published: July 2024

Objective

This study aims to determine whether tele-rehabilitation has similar effects to conventional face-to-face physical rehabilitation for diabetic patients with heart failure with preserved ejection fraction (HFpEF).

Materials and methods

Demographic, laboratory, diagnostic and rehabilitation information for patients with type 2 diabetes with HFpEF were extracted from disease-specific databases. Outcome measures, including the Short Physical Performance Battery (SPPB), 6-minute walk distance, frailty status, European Quality of Life 5-Dimension 5-Level questionnaire (EQ-5D-5L) and reduction in HbA1c from admission, patients who received tele-rehabilitation therapy were compared to those received face-to-face rehabilitation.

Results

In this study, 90 patients with type 2 diabetes and HFpEF using tele-rehabilitation were matched with 90 patients with type 2 diabetes and HFpEF using face-to-face physical rehabilitation. Improvements in the results of the SPPB scores, 6-min walk distance and gait speed and EQ-5D-5L were noted from the follow-up time point 3 months to 6 months in both two groups. There were no significant differences in functional tests and quality of life between the two groups.

Conclusion

Our study proved that mobile-based tele-rehabilitation programs are non-inferior to face-to-face physical rehabilitation for diabetes patients after HFpEF. In addition, adherence to the telerehabilitation program showed that the novel technology was accepted well and could be an alternative to the conventional face-to-face rehabilitation program.
Refugee agency in secondary mobility decision-making: a systematic literature review
Authors: Kavak Sinem , Hamza Mo , Gammeltoft-Hansen Thomas , Stone Russell A.
Published: July 2024

Decisions made by millions of refugees about where to go, how to make a living and how to secure a future are fundamental drivers of secondary movements. While a substantial body of literature addresses factors contributing to migrants’ decision-making, a comprehensive understanding of the central role of refugees in secondary mobility decision-making, including agency and strategies employed, remains underexplored. This is partly due to the belief that refugees are constrained by external and structural factors and cannot exercise agency, which we challenge. This article provides a systematic analysis of the literature on refugees’ secondary mobility decision-making processes. Using a systematic literature review (SLR) methodology, it presents an in-depth analysis of 40 peer-reviewed, English-language research articles selected from the Web of Science and Scopus databases published before September 2022. The article critically examines the drivers, prevailing dichotomies and conceptual frameworks surrounding refugee categorization, agency, and mobility. By synthesizing a wide range of literature, our paper presents emerging alternative concepts and frameworks that shed light on the complex dynamics of decision-making.
A novel approach with tofacitinib for the management of keratoderma blennorrhagicum in reactive arthritis: a case report
Authors: Maitiyaer Maierhaba , Liu Yu , Keyimu Nueramina , Wen Yueqiang , Liu Zhiping , Huang Wenhui , Yu Shuilian
Published: July 2024

Reactive arthritis(ReA), a form of arthritis occurring post-infection, manifests with antecedent infection symptoms, arthritis, and extra-articular manifestations, categorizing it as spondyloarthritis. “Keratoderma blennorrhagicum” (characterized by pustular hyperkeratosis on palms and soles, resembling pustular psoriasis) represents the most typical skin manifestation of ReA, occurring in acute or chronic phases. Severe lesions necessitate systemic disease modifying anti-rheumatic drugs (DMARDs) or biologic therapies. This article reports a case of ReA with sacroiliitis and widespread pustular eruptions following a urinary tract infection. Treatment with sulfasalazine and thalidomide significantly improved sacroiliitis, but the skin rash remained persistent and recurring. Subsequent use of adalimumab and secukinumab resulted in worsening skin rash, prompting a switch to tofacitinib, leading to a remarkable improvement in pustular eruptions after 20 days of treatment. This case demonstrates successful application of tofacitinib in treating severe keratoderma blennorrhagicum refractory to conventional DMARDs and biologics, offering insights into JAK inhibition for challenging rheumatic diseases with skin involvement.
A universal artificial diet for corn rootworm (Diabrotica spp.) larval biopesticide assays
Authors: Ho Khanh-Van , Hibbard Bruce E. , Do Thu T. H. , Pekarcik Adrian J. , Huynh Man P.
Published: July 2024

We identified a single diet formulation that can be used for three Diabrotica species including southern (SCR), western (WCR), and northern corn rootworm (NCR) by evaluating the performance of these pests on specialized diets (F9800B diet for SCR, WCRMO-2 diet for WCR, and NCRMO-1 diet for NCR) and a larval diet (F9772 diet) widely used for lepidopteran species. After 10 days of rearing, the WCRMO-2 diet yielded better or equal larval growth and development of all three rootworm species compared to other diets. For SCR larvae, the WCRMO-2 diet outperformed other diets. Larval fresh weight, percent molt to 2nd instar, and percent molt to 3rd instar on the WCRMO-2 diet were 12-fold, 2.7-fold, and 14-fold increases, respectively compared to that of the F9800B diet. Significantly more SCR larvae survived on the WCRMO-2 diet (98.9%) than on the F9800B diet (90.6%). The WCRMO-2 diet supported WCR and NCR larvae equal to the NCRMO-1 diet and better than other diets. The F9772 diet was the worst diet of all examined species. The availability of a universal diet (the WCRMO-2 diet) for the three Diabrotica species would facilitate research programs to monitor resistance development and develop new control tactics targeting these important pests.
Microglia depletion leads to increased susceptibility to ocular hypertension-dependent glaucoma
Authors: Diemler Cory A. , MacLean Michael , Heuer Sarah E. , Hewes Amanda A. , Marola Olivia J. , Libby Richard T. , Howell Gareth R.
Published: July 2024

In recent years, microglia have been highlighted for playing integral roles in neurodegenerative diseases, like glaucoma. To better understand the role of microglia during chronic ocular hypertension, we depleted microglia from aged (9–12 months old) DBA/2 J (D2) mice, which exhibit age-related increases in intraocular pressure, using a dietary CSF1R antagonist, PLX5622. Retinal ganglion cell (RGC) somas were counted, and optic nerve cross-sections stained and assessed for glaucomatous damage. Sustained administration of dietary PLX5622 significantly reduced the numbers of retinal microglia. Dietary PLX5622 did not lead to changes in intraocular pressure in D2 or normotensive DBA/2 J-Gpnmb+ (D2-Gpnmb+) control mice. While PLX5622-treated D2-Gpnmb+ did not develop optic nerve damage, PLX5622-treated D2 mice showed a significant increase in moderate-to-severe optic nerve damage compared to D2 mice fed a control diet. In conclusion, global reduction of microglia exacerbated glaucomatous neurodegeneration in D2 mice suggesting microglia play an overall beneficial role in protecting from ocular hypertension associated RGC loss.
Time-varying effect in older patients with early-stage breast cancer: a model considering the competing risks based on a time scale
Authors: Yu Zhiyin , Geng Xiang , Li Zhaojin , Zhang Chengfeng , Hou Yawen , Zhou Derun , Chen Zheng
Published: July 2024

Background

Patients with early-stage breast cancer may have a higher risk of dying from other diseases, making a competing risks model more appropriate. Considering subdistribution hazard ratio, which is used often, limited to model assumptions and clinical interpretation, we aimed to quantify the effects of prognostic factors by an absolute indicator, the difference in restricted mean time lost (RMTL), which is more intuitive. Additionally, prognostic factors of breast cancer may have dynamic effects (time-varying effects) in long-term follow-up. However, existing competing risks regression models only provide a static view of covariate effects, leading to a distorted assessment of the prognostic factor.

Methods

To address this issue, we proposed a dynamic effect RMTL regression that can explore the between-group cumulative difference in mean life lost over a period of time and obtain the real-time effect by the speed of accumulation, as well as personalized predictions on a time scale.

Results

A simulation validated the accuracy of the coefficient estimates in the proposed regression. Applying this model to an older early-stage breast cancer cohort, it was found that 1) the protective effects of positive estrogen receptor and chemotherapy decreased over time; 2) the protective effect of breast-conserving surgery increased over time; and 3) the deleterious effects of stage T2, stage N2, and histologic grade II cancer increased over time. Moreover, from the view of prediction, the mean C-index in external validation reached 0.78.

Conclusion

Dynamic effect RMTL regression can analyze both dynamic cumulative effects and real-time effects of covariates, providing a more comprehensive prognosis and better prediction when competing risks exist.
Baseline assessment of cervical cancer screening and treatment capacity in 25 counties in Kenya, 2022
Authors: Mwenda Valerian , Murage David , Kilonzo Catherine , Bor Joan-Paula , Njiri Patricia , Osiro Lance , Nyangasi Mary , Arbyn Marc , Tummers Philippe , Temmerman Marleen
Published: July 2024

Background

Cervical cancer is the leading cause of cancer deaths among women in Kenya. In the context of the Global strategy to accelerate the elimination of cervical cancer as a public health problem, Kenya is currently implementing screening and treatment scale-up. For effectively tracking the scale-up, a baseline assessment of cervical cancer screening and treatment service availability and readiness was conducted in 25 priority counties. We describe the findings of this assessment in the context of elimination efforts in Kenya.

Methods

The survey was conducted from February 2021 to January 2022. All public hospitals in the target counties were included. We utilized healthcare workers trained in preparation for the scale-up as data collectors in each sub-county. Two electronic survey questionnaires (screening and treatment; and laboratory components) were used for data collection. All the health system building blocks were assessed. We used descriptive statistics to summarize the main service readiness indicators.

Results

Of 3,150 hospitals surveyed, 47.6% (1,499) offered cervical cancer screening only, while 5.3% (166) offered both screening and treatment for precancer lesions. Visual inspection with acetic acid (VIA) was used in 96.0% (1,599/1,665) of the hospitals as primary screening modality and HPV testing was available in 31 (1.0%) hospitals. Among the 166 hospitals offering treatment for precancerous lesions, 79.5% (132/166) used cryotherapy, 18.7% (31/166) performed thermal ablation and 25.3% (42/166) performed large loop excision of the transformation zone (LLETZ). Pathology services were offered in only 7.1% (17/238) of the hospitals expected to have the service (level 4 and above). Only 10.8% (2,955/27,363) of healthcare workers were trained in cervical cancer screening and treatment; of these, 71.0% (2,097/2,955) were offering the services. Less than half of the hospitals had cervical cancer screening and treatment commodities at time of survey. The main health system strength was presence of multiple screening points at hospitals, but frequent commodity stock-outs was a key weakness.

Conclusion

Training, commodities, and diagnostic services are major gaps in the cervical cancer program in Kenya. To meet the 2030 elimination targets, the national and county governments should ensure adequate financing, training, and service integration, especially at primary care level.
Multiple aspects of matrix stiffness in cancer progression
Authors: Mancini Alessandro , Gentile Maria Teresa , Pentimalli Francesca , Cortellino Salvatore , Grieco Michele , Giordano Antonio
Published: July 2024

The biophysical and biomechanical properties of the extracellular matrix (ECM) are crucial in the processes of cell differentiation and proliferation. However, it is unclear to what extent tumor cells are influenced by biomechanical and biophysical changes of the surrounding microenvironment and how this response varies between different tumor forms, and over the course of tumor progression. The entire ensemble of genes encoding the ECM associated proteins is called matrisome. In cancer, the ECM evolves to become highly dysregulated, rigid, and fibrotic, serving both pro-tumorigenic and anti-tumorigenic roles. Tumor desmoplasia is characterized by a dramatic increase of α-smooth muscle actin expressing fibroblast and the deposition of hard ECM containing collagen, fibronectin, proteoglycans, and hyaluronic acid and is common in many solid tumors. In this review, we described the role of inflammation and inflammatory cytokines, in desmoplastic matrix remodeling, tumor state transition driven by microenvironment forces and the signaling pathways in mechanotransduction as potential targeted therapies, focusing on the impact of qualitative and quantitative variations of the ECM on the regulation of tumor development, hypothesizing the presence of matrisome drivers, acting alongside the cell-intrinsic oncogenic drivers, in some stages of neoplastic progression and in some tumor contexts, such as pancreatic carcinoma, breast cancer, lung cancer and mesothelioma.
Functions, accumulation, and biosynthesis of important secondary metabolites in the fig tree (Ficus carica)
Authors: Wang Yawen , Liu Ximeng , Chen Siyu , Wang Qingjie , Jin Biao , Wang Li
Published: July 2024

Ficus carica is an economically important horticultural plant. Due to its abundant secondary metabolites, F. carica has gained interest for its applications in medicine and as a nutritional supplement. Both external and internal factors affect the accumulation of secondary metabolites in F. carica. The assembly of the F. carica genome has facilitated functional analysis of key genes and transcription factors associated with the biosynthesis of secondary metabolites, particularly anthocyanin. In this review, we summarize the various types and functions of secondary metabolites, with a particular focus on flavonoids, coumarins, and terpenes. We also explore the factors influencing their biosynthesis and accumulation, including varieties, tissue, environmental factors (e.g., light), stresses (e.g., high temperature, low temperature, drought, nutrient deficiencies, salinity), hormonal treatments, and developmental factors. Furthermore, we discuss the involvement of structural genes and transcription factors in the biosynthesis of secondary metabolites, specifically anthocyanin and furanocoumarins, knowledge of which will promote the breeding and genetic engineering of novel F. carica varieties.
Depressive symptoms of older adults with chronic diseases: the mediating roles of activities of daily living and economic burden of diseases
Authors: Ni Zihan , Zhu Xiuyuan , Tian Kan , Chen Qing , Yang Yi , Xie Shiyu
Published: July 2024

Objective

To explore the mediating roles of activities of daily living (ADL) and economic burden of diseases in the relationship between chronic diseases and depressive symptoms of older adults.

Methods

The data were sourced from China Health and Retirement Longitudinal Study (CHARLS). The number of chronic diseases, ADL, out-of-pocket medical expenses and the Center for Epidemiological Studies Depression Scale (CES-D) were selected as measuring indexes. Mediation analysis was conducted to explore the potential mediating roles of ADL and economic burden of diseases in the association between chronic diseases and depressive symptoms.

Results

The number of chronic diseases, ADL, economic burden of diseases and depressive symptoms of older adults were significantly correlated with each other. ADL and economic burden of diseases individually mediated the relationship between the number of chronic diseases and depressive symptoms, accounting for 31.460% and 5.471% of the total effect, respectively. Additionally, ADL and economic burden of diseases demonstrated a chain mediating effect in this relationship, contributing to 0.759% of the total effect.

Conclusion

The chain-mediated model effectively elucidated the mediating roles of ADL and economic burden of diseases in the association between chronic diseases and depressive symptoms among older adults. The study underscores the need for policymakers to focus attentively on the mental health of older adults with chronic diseases. Enhancing the capacity for ADL and strengthening social security to mitigate the economic burden of diseases are recommended strategies to alleviate depressive symptoms in older adults.
Infant attention to rhythmic audiovisual synchrony is modulated by stimulus properties
Authors: Cirelli Laura K. , Talukder Labeeb S. , Kragness Haley E.
Published: July 2024

Musical interactions are a common and multimodal part of an infant’s daily experiences. Infants hear their parents sing while watching their lips move and see their older siblings dance along to music playing over the radio. Here, we explore whether 8- to 12-month-old infants associate musical rhythms they hear with synchronous visual displays by tracking their dynamic visual attention to matched and mismatched displays. Visual attention was measured using eye-tracking while they attended to a screen displaying two videos of a finger tapping at different speeds. These videos were presented side by side while infants listened to an auditory rhythm (high or low pitch) synchronized with one of the two videos. Infants attended more to the low-pitch trials than to the high-pitch trials but did not display a preference for attending to the synchronous hand over the asynchronous hand within trials. Exploratory evidence, however, suggests that tempo, pitch, and rhythmic complexity interactively engage infants’ visual attention to a tapping hand, especially when that hand is aligned with the auditory stimulus. For example, when the rhythm was complex and the auditory stimulus was low in pitch, infants attended to the fast hand more when it aligned with the auditory stream than to misaligned trials. These results suggest that the audiovisual integration in rhythmic non-speech contexts is influenced by stimulus properties.
Treatment of bipolar depression: clinical practice vs. adherence to guidelines—data from a Bavarian drug surveillance project
Authors: Kriner Paul , Brieger Peter , Pogarell Oliver , Schüle Cornelius , Mußmann Lisa , Korbmacher Julie , Seemüller Florian
Published: July 2024

Objectives

Pharmacotherapy of bipolar depression (BPD) is confronted with major clinical challenges, like limited evidence-based treatment options, regular cases of treatment resistance, and risk of treatment-emergent affective switches. Medical guidelines can support practitioners to make decisions based on current scientific evidence. The objective of this study is to evaluate to what extent recommendations of the 2019 German S3 guidelines “Diagnosis and Treatment of Bipolar Disorders” are reflected in clinical practice in inpatient treatment.

Methods

We conducted a descriptive analysis of prescription numbers in 2,627 patients with BPD in a naturalistic inpatient setting analyzing data from the ongoing Bavarian multicenter drug safety project Pharmaco-Epidemiology and Vigilance (Pharmako-EpiVig) from the years 2014–2022.

Results

Of the patients, 38% were not administered any drug explicitly recommended for treatment of BPD, that is, quetiapine, lamotrigine, carbamazepine, or olanzapine. Only 6% of the patients received monotherapy with one of those drugs. Of the patients, 34% were administered ≥4 psychotropic drugs simultaneously. Patients received 912 different therapy regimens of mono or combination therapy with mood stabilizers (MS), atypical antipsychotics (AAP), and antidepressants. Of the patients, 72% received an antidepressant and 6% without concomitant prescription of an AAP or MS. Prescription rates of venlafaxine (21% to 14%) and tricyclic antidepressants (9% to 6%) decreased significantly from the first (2014–2016) to the last (2020–2022) observed time period. Of the patients, 60% received an MS. Prescription rate of valproate (22% to 14%) decreased significantly, while lithium prescription increased significantly (29% to 35%). Of the patients, 71% were administered an AAP. Quetiapine was the most prescribed drug overall (43%). Only two patients were administered a combination of olanzapine and fluoxetine.

Conclusion

Our results demonstrate a substantial gap between guideline recommendations and current clinical practice. The remarkable heterogeneity in treatment regimens, with no discernible dominant treatment approach, is in part a reflection of the complexity of bipolar disorder but also substantiates the need of comprehensive recommendations regarding combination therapies. Increase in lithium prescription is an encouraging development due to its unique efficacy in maintenance treatment. To improve the quality of clinical practice guideline implementation, more randomized controlled trials should be conducted in the future to prospectively investigate different implementation strategies.
ArabBert-LSTM: improving Arabic sentiment analysis based on transformer model and Long Short-Term Memory
Authors: Alosaimi Wael , Saleh Hager , Hamzah Ali A. , El-Rashidy Nora , Alharb Abdullah , Elaraby Ahmed , Mostafa Sherif
Published: July 2024

Sentiment analysis also referred to as opinion mining, plays a significant role in automating the identification of negative, positive, or neutral sentiments expressed in textual data. The proliferation of social networks, review sites, and blogs has rendered these platforms valuable resources for mining opinions. Sentiment analysis finds applications in various domains and languages, including English and Arabic. However, Arabic presents unique challenges due to its complex morphology characterized by inflectional and derivation patterns. To effectively analyze sentiment in Arabic text, sentiment analysis techniques must account for this intricacy. This paper proposes a model designed using the transformer model and deep learning (DL) techniques. The word embedding is represented by Transformer-based Model for Arabic Language Understanding (ArabBert), and then passed to the AraBERT model. The output of AraBERT is subsequently fed into a Long Short-Term Memory (LSTM) model, followed by feedforward neural networks and an output layer. AraBERT is used to capture rich contextual information and LSTM to enhance sequence modeling and retain long-term dependencies within the text data. We compared the proposed model with machine learning (ML) algorithms and DL algorithms, as well as different vectorization techniques: term frequency-inverse document frequency (TF-IDF), ArabBert, Continuous Bag-of-Words (CBOW), and skipGrams using four Arabic benchmark datasets. Through extensive experimentation and evaluation of Arabic sentiment analysis datasets, we showcase the effectiveness of our approach. The results underscore significant improvements in sentiment analysis accuracy, highlighting the potential of leveraging transformer models for Arabic Sentiment Analysis. The outcomes of this research contribute to advancing Arabic sentiment analysis, enabling more accurate and reliable sentiment analysis in Arabic text. The findings reveal that the proposed framework exhibits exceptional performance in sentiment classification, achieving an impressive accuracy rate of over 97%.
Optimized quantization parameter selection for video-based point cloud compression
Authors: Yuan Hui , Hamzaoui Raouf , Neri Ferrante , Yang Shengxiang , Lu Xin , Zhu Linwei , Zhang Yun
Published: July 2024

Point clouds are sets of points used to visualize three-dimensional (3D) objects. Point clouds can be static or dynamic. Each point is characterized by its 3D geometry coordinates and attributes such as color. High-quality visualizations often require millions of points, resulting in large storage and transmission costs, especially for dynamic point clouds. To address this problem, the moving picture experts group has recently developed a compression standard for dynamic point clouds called video-based point cloud compression (V-PCC). The standard generates two-dimensional videos from the geometry and color information of the point cloud sequence. Each video is then compressed with a video coder, which converts each frame into frequency coefficients and quantizes them using a quantization parameter (QP). Traditionally, the QPs are severely constrained. For example, in the low-delay configuration of the V-PCC reference software, the quantization parameter values of all the frames in a group of pictures are set to be equal. We show that the rate-distortion performance can be improved by relaxing this constraint and treating the QP selection problem as a multi-variable constrained combinatorial optimization problem, where the variables are the QPs. To solve the optimization problem, we propose a variant of the differential evolution (DE) algorithm. Differential evolution is an evolutionary algorithm that has been successfully applied to various optimization problems. In DE, an initial population of randomly generated candidate solutions is iteratively improved. At each iteration, mutants are generated from the population. Crossover between a mutant and a parent produces offspring. If the performance of the offspring is better than that of the parent, the offspring replaces the parent. While DE was initially introduced for continuous unconstrained optimization problems, we adapt it for our constrained combinatorial optimization problem. Also, unlike standard DE, we apply individual mutation to each variable. Furthermore, we use a variable crossover rate to balance exploration and exploitation. Experimental results for the low-delay configuration of the V-PCC reference software show that our method can reduce the average bitrate by up to 43% compared to a method that uses the same QP values for all frames and selects them according to an interior point method.
Outcome in acute ischemic stroke patients with large-vessel occlusion and initial mild deficits
Authors: Kazmi Jacob S. , O'Hara Joseph , Gandomi Amir , Wang Jason J. , Sanmartin Maria X. , Yang Bo , Sanelli Pina C. , Katz Jeffrey M.
Published: July 2024

Background

The management of patients with initially mild acute ischemic stroke (AIS), defined by the National Institutes of Health Stroke Scale (NIHSS) scores 0–5, remains ambiguous despite advances in stroke treatment. The early identification of patients likely to deteriorate is critical in preventing lasting disability.

Aims

We investigated the frequency and early predictors of poor functional outcomes in AIS patients with large-vessel occlusion (LVO) and initial mild deficits.

Methods

We performed a retrospective observational study of consecutive AIS patients admitted to a single comprehensive stroke center between 2018 and 2021. The inclusion criteria were a diagnosis of AIS, an arrival NIHSS score of 0–5, imaging-confirmed LVO, and arrival within 24 h of the last-known-well time. The primary outcome was the change in the discharge-modified Rankin Score (ΔmRS) from baseline, categorized as 0–1 (stable outcome) or >1 (poor outcome). Early neurological deterioration was defined as a mean NIHSS score increase of >1 in the first 24-h period. Univariate and multivariable regression analyses were performed. The mean daily NIHSS scores were compared between groups using an analysis of variance (ANOVA).

Results

Of 4,410 stroke admissions, 120 patients met the study inclusion criteria, with 71 (59.2%) patients having a ΔmRS of 0–1 and 49 (40.8%) patients having a ΔmRS of > 1. The mean arrival NIHSS score was similar between groups. However, the mean first-24-h NIHSS score was significantly higher in the poor outcome group vs. the stable outcome group (2.13 vs. 0.95, p < 0.001). A demographic-adjusted multivariable logistic regression revealed that a higher mean first-24-h NIHSS score was the sole early predictor of poor outcome (odds ratio [OR] of 1.65 and a 95% confidence interval [CI] of [1.18, 2.48]). The only association with early neurological deterioration was vertebral artery occlusion, with an OR of 0.35 and a 95% CI of [0.14, 0.81]. The trending mean daily NIHSS scores revealed that patients with poor outcomes deteriorate within 24 h, a significant difference from the stable group (p < 0.001).

Conclusion

Poor outcomes occurred in a significant proportion of LVO patients with initial mild deficits. The only association was early neurological deterioration. To prevent poor outcomes, rapid identification of any clinical deterioration should prompt consideration of thrombectomy.
Is Night Surgery a Nightmare for Lung Transplantation?
Authors: Tanaka Sébastien , De Tymowski Christian , Dupuis Erevan , Tran-Dinh Alexy , Lortat-Jacob Brice , Harpan Adela , Jean-Baptiste Sylvain , Boudinet Sandrine , Tahri Chahra-Zad , Salpin Mathilde , Castier Yves , Mordant Pierre , Mal Hervé , Girault Antoine , Atchade Enora , Montravers Philippe ,   the Bichat Lung Transplant Group
Published: July 2024

Night work is frequently associated with sleep deprivation and is associated with greater surgical and medical complications. Lung transplantation (LT) is carried out both at night and during the day and involves many medical healthcare workers. The goal of the study was to compare morbidity and mortality between LT recipients according to LT operative time. We performed a retrospective, observational, single-center study. When the procedure started between 6 AM and 6 PM, the patient was allocated to the Daytime group. If the procedure started between 6 PM and 6 AM, the patient was allocated to the Nighttime group. Between January 2015 and December 2020, 253 patients were included. A total of 168 (66%) patients were classified into the Day group, and 85 (34%) patients were classified into the Night group. Lung Donors’ general characteristics were similar between the groups. The 90-day and one-year mortality rates were similar between the groups (90-days: n = 13 (15%) vs. n = 26 (15%), p = 0.970; 1 year: n = 18 (21%) vs. n = 42 (25%), p = 0.499). Daytime LT was associated with more one-year airway dehiscence (n = 36 (21%) vs. n = 6 (7.1%), p = 0.004). In conclusion, among patients who underwent LT, there was no significant association between operative time and survival.
Matching the Ideal Pruning Method with Knowledge Distillation for Optimal Compression
Authors: Malihi Leila , Heidemann Gunther
Published: July 2024

In recent years, model compression techniques have gained significant attention as a means to reduce the computational and memory requirements of deep neural networks. Knowledge distillation and pruning are two prominent approaches in this domain, each offering unique advantages in achieving model efficiency. This paper investigates the combined effects of knowledge distillation and two pruning strategies, weight pruning and channel pruning, on enhancing compression efficiency and model performance. The study introduces a metric called “Performance Efficiency” to evaluate the impact of these pruning strategies on model compression and performance. Our research is conducted on the popular datasets CIFAR-10 and CIFAR-100. We compared diverse model architectures, including ResNet, DenseNet, EfficientNet, and MobileNet. The results emphasize the efficacy of both weight and channel pruning in achieving model compression. However, a significant distinction emerges, with weight pruning showing superior performance across all four architecture types. We realized that the weight pruning method better adapts to knowledge distillation than channel pruning. Pruned models show a significant reduction in parameters without a significant reduction in accuracy.
Optimized Grid Partitioning and Scheduling in Multi-Energy Systems Using a Hybrid Decision-Making Approach
Authors: Liu Peng , Zhang Tieyan , Tian Furui , Teng Yun , Yang Miaodong
Published: July 2024

This paper presents a thorough review of our state-of-the-art technique for enhancing dynamic grid partitioning and scheduling in multi-energy source systems. We use a hybrid approach to T-spherical fuzzy sets, combining the alternative ranking order method accounting for the two-step normalization (AROMAN) method for alternating ranking order to enable two-step normalisation with the method based on removal effects of criteria (MEREC) for eliminating criteria effects. This enables us to obtain the highest level of accuracy from our findings. To ascertain the relative importance of these criteria, we use MEREC to perform a rigorous examination of the influence that each evaluation criterion has on the outcomes of the decision-making process. In addition, we use AROMAN to provide a strong foundation for assessing potential solutions by accounting for spherical fuzzy sets to account for any ambiguity. We illustrate how our approach successfully considers several factors, such as social acceptability, technical feasibility, environmental sustainability, and economic feasibility, through the analysis of an extensive case study. Our approach provides decision-makers (DMs) with a rigorous and rational framework for assessing and choosing the best grid division and scheduling options. This is done in an effort to support the administration and design of resilient and sustainable multi-energy systems. This research contributes to the growing body of knowledge in this area by offering insights that help to direct policy, planning, and investment decisions in the shift towards more sustainable energy infrastructures. Moreover, it adds to the growing body of information on multi-criteria decision-making (MCDM) in energy system optimization.