bluuebunny/crossref_metadata_2025 huggingface dataset:
Mi Vida Saludable: Content Validity and Reliability of The Preferences and Self-Efficacy of Diet and Physical Activity Behaviors Questionnaire for Latina Women (PSEDPALW) for Cancer Survivors
Authors: Koch Pamela A. , Paul Rachel , Contento Isobel R. , Gray Heewon L. , Marín-Chollom Amanda M. , Santiago-Torres Margarita , Shen Hanjie , Jones Salene M. W. , Hershman Dawn L. , Greenlee Heather
Published: August 2023

The purpose of this study is to conduct validity and reliability testing of a new instrument, the Preferences and Self-Efficacy of Diet and Physical Activity Behaviors Questionnaire for Latina Women (PSEDPALW), which is for women who identify as Latina and are breast cancer survivors. PSEDPALW measures preferences and self-efficacy for four behaviors: physical activity (PA), fruit and vegetable (FV) intake, dietary fat (DF) intake, and added sugar (AS) intake (eight scales in total). Validity testing was conducted through an expert panel review and a cognitive interviewing focus group (n = 4). Reliability was tested via internal consistency reliability (n = 118) and test–retest reliability (n = 30). Validity testing was used to refine PSEDPALW. Reliability testing was conducted on three versions with 104, 47, and 41 items. PA scales had acceptable Cronbach’s α (>0.70) but low ICC (NS). FV and DF scales had acceptable Cronbach’s α (>0.70), with preferences for the shorter (47- and 41-item) versions (Cronbach’s α < 0.70), and all scales had moderate ICC (p < 0.05, except the FV scale on the 104-item version (p = 0.07)). The AS preferences scale had Cronbach’s α < 0.70, with self-efficacy > 0.70 for all versions and ICC moderate for all versions (p ≤ 0.01). PSEDPALW may be useful to assess diet and physical activity preferences and self-efficacy in theory-based diet and physical activity interventions in women who identify as Latina and are breast cancer survivors.
The Effects of Creatine Monohydrate Loading on Exercise Recovery in Active Women throughout the Menstrual Cycle
Authors: Gordon Amanda N. , Moore Sam R. , Patterson Noah D. , Hostetter Maggie E. , Cabre Hannah E. , Hirsch Katie R. , Hackney Anthony C. , Smith-Ryan Abbie E.
Published: August 2023

Creatine supplementation improves anaerobic performance and recovery; however, to date, these outcomes have not been well explored in females. This study evaluated the effect of creatine monohydrate loading on exercise recovery, measured by heart rate variability (HRV) and repeated sprint performance, in women across the menstrual cycle. In this randomized, double-blind, cross-over study, 39 women (mean ± standard deviation: age: 24.6 ± 5.9 years, height: 172.5 ± 42.3 cm, weight: 65.1 ± 8.1 kg, BF: 27.4 ± 5.8%) were randomized to a creatine monohydrate (n = 19; 20 g per day in 4 × 5 g doses) or non-caloric PL group (n = 20). HRV was measured at rest and after participants completed a repeated sprint cycling test (10 × 6 s maximal sprints). Measurements were conducted before and after supplementation in the follicular/low hormone and luteal/high hormone phases. Creatine monohydrate supplementation did not influence HRV values, as no significant differences were seen in HRV values at rest or postexercise. For repeated sprint outcomes, there was a significant phase × supplement interaction (p = 0.048) for fatigue index, with the greatest improvement seen in high hormone in the creatine monohydrate group (−5.8 ± 19.0%) compared to changes in the PL group (0.1 ± 8.1%). Sprint performance and recovery were reduced by the high hormone for both groups. Though not statistically significant, the data suggests that creatine monohydrate could help counteract performance decrements caused by the high hormone. This data can help inform creatine monohydrate loading strategies for females, demonstrating potential benefits in the high hormone phase.
Supplemented Very Low Protein Diet (sVLPD) in Patients with Advanced Chronic Renal Failure: Clinical and Economic Benefits
Authors: Cecchi Sofia , Di Stante Silvio , Belcastro Sara , Bertuzzi Veronica , Cardillo Assunta , Diotallevi Laura , Grabocka Xhensila , Kulurianu Hrissa , Martello Mauro , Nastasi Valentina , Paci Della Costanza Osmy , Pizzolante Francesca , Di Luca Marina
Published: August 2023

The supplemented very low-protein diet (sVLPD) has proven effective in slowing the progression of stage 5 chronic renal failure and postponing the start of the dialysis treatment. However, sVLPD could expose the patient to the risk of malnutrition. This diet is also difficult to implement due to the required intake of large number of keto-analogue/amino acid tablets. In our Center, the Department of Nephrology and Dialysis of Azienda Sanitaria Territoriale n 1, Pesaro-Urbino, of Italy, respecting the guidelines of normal clinical practice, we prescribed sVLPD (0.3 g/prot/day) supplemented with only essential amino acids without the use of ketoanalogues in stage 5 patients and verified its efficacy, safety and clinical and economic effects. Over the 24 months period of observation the progression of chronic kidney disease (CKD) slowed down (mean eGFR 11.6 ± 3.3 vs. 9.3 ± 2.7 mL/min/1.73 m2, p < 0.001) and the start of the dialysis treatment (adjusted HR = 0.361, CI 0.200–0.650, p = 0.001) was delayed without evidence of malnutrition, in compliant vs. non-compliant patients. This led to a substantial cost reduction for the National Health System. This non-interventional longitudinal observational study is part of standard clinical practice and suggests that VLPD supplemented with essential amino acids could be extensively used to reduce the incidence of dialysis treatments, with a favorable economic impact on the NHS.
Gut Microbiota and Critically Ill Patients: Immunity and Its Modulation via Probiotics and Immunonutrition
Authors: Abenavoli Ludovico , Scarpellini Emidio , Paravati Maria Rosaria , Scarlata Giuseppe Guido Maria , Boccuto Luigi , Tilocca Bruno , Roncada Paola , Luzza Francesco
Published: August 2023

Critically ill patients have a hyper-inflammatory response against various offending injuries that can result in tissue damage, organ failure, and fatal prognosis. The origin of this detrimental, uncontrolled inflammatory cascade can be found also within our gut. In detail, one of the main actors is our gut microbiota with its imbalance, namely gut dysbiosis: learning about the microbiota’s dysfunction and pathophysiology in the frame of critical patients is of crucial and emerging importance in the management of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS). Multiple pieces of evidence indicate that the bacteria that populate our gut efficiently modulate the immune response. Treatment and pretreatment with probiotics have shown promising preliminary results to attenuate systemic inflammation, especially in postoperative infections and ventilation performance. Finally, it is emerging how immunonutrition may exert a possible impact on the health status of patients in intensive care. Thus, this manuscript reviews evidence from the literature on gut microbiota composition, its derangement in critically ill patients, its pathophysiological role, and the described and emerging opportunities arising from its modulation.
Malnutrition Defined by the Global Leadership Initiative on Malnutrition (GLIM) Criteria in Hospitalized Patients with Ulcerative Colitis and Its Association with Clinical Outcomes
Authors: Wei Wei , Yan Pengguang , Wang Fang , Bai Xiaoyin , Wang Jing , Li Jingnan , Yu Kang
Published: August 2023

(1) Background: The Global Leadership Initiative on Malnutrition (GLIM) was published in 2019, and its application has been explored in several diseases. However, the data on malnutrition based on the GLIM in ulcerative colitis (UC) patients are sparse. (2) Methods: This single-center, retrospective cohort study included 605 hospitalized UC patients. Demographics and clinical data were collected from electronic medical records. Nutritional Risk Screening 2002 (NRS 2002) was used as a screening tool, and malnutrition was diagnosed according to the GLIM criteria. The skeletal muscle area of the third lumber cross-section in abdominal computed tomography was used to evaluate muscle mass within one week before or after admission. (3) Results: The prevalence of malnutrition was 64.1% in this cohort, and the prevalences were 34.2, 57.7, and 86.7% in UC patients with mild, moderate, and severe disease activity, respectively. Malnourished patients tended to need surgical treatment (p = 0.080) and had a 2.4 times greater risk of opportunistic infection. The multivariate logistic regression analysis showed that UC patients with malnutrition had a 1.7-fold increased risk of readmission. (4) Conclusions: Nutritional problems deserve more attention in hospitalized UC patients. Malnutrition identified through the GLIM criteria was associated with opportunistic infection, tended to be associated with surgical treatment, and showed a prognosis value for readmission.
Adipose Tissue Denervation Blunted the Decrease in Bone Formation Promoted by Obesity in Rats
Authors: Ormanji Milene Subtil , Melo Maria Victória Lazarini , Meca Renata , Garcia Michelle Louvaes , Anauate Ana Carolina , Muñoz Juan José Augusto Moyano , Oyama Lila Missae , Nishi Erika Emy , Bergamaschi Cassia Toledo , Carvalho Aluizio Barbosa , Heilberg Ita Pfeferman
Published: August 2023

The impact of obesity upon bone metabolism is controversial since both beneficial or harmful effects have been reported. Bone remodeling is modulated by the central nervous system through cytokines, hormones and neuromodulators. The present study aimed to evaluate the effects evoked by bilateral retroperitoneal white adipose tissue (rWAT) denervation (Dnx) upon bone mineral metabolism and remodeling in an experimental model of obesity in rats. Male Wistar rats were fed during 18 weeks with high-fat diet (HFD) or standard diet (SD) as controls, and rWAT Dnx or Sham surgery was performed at the 14th week. Biochemical and hormonal parameters, bone histomorphometry, rWAT and hypothalamus protein and gene expression were analyzed. The HFD group presented decreased bone formation parameters, increased serum and bone leptin and FGF23, increased serum and hypothalamic neuropeptide Y (NPY) and decreased serum 1,25-dihydroxyvitamin D3 and PTH. After rWAT Dnx, bone markers and histomorphometry showed restoration of bone formation, and serum and hypothalamic NPY decreased, without alteration in leptin levels. The present study shows that the denervation of rWAT improved bone formation in obese rats mediated by a preferential reduction in neurohormonal actions of NPY, emphasizing the relevance of the adipose tissue–brain–bone axis in the control of bone metabolism in obesity.
Occupational Health Applied Infodemiological Studies of Nutritional Diseases and Disorders: Scoping Review with Meta-Analysis
Authors: Palomo-Llinares Ruben , Sánchez-Tormo Julia , Wanden-Berghe Carmina , Sanz-Valero Javier
Published: August 2023

(1) Objective: to identify and review existing infodemiological studies on nutritional disorders applied to occupational health and to analyse the effect of the intervention on body mass index (BMI) or alternatively body weight (BW); (2) Methods: This study involved a critical analysis of articles retrieved from MEDLINE (via PubMed), Embase, Cochrane Library, PsycINFO, Scopus, Web of Science, Latin American, and Caribbean Health Sciences Literature (LILACS) and Medicina en Español (MEDES) using the descriptors “Nutrition Disorders, “Occupational Health” and “Infodemiology”, applying the filters “Humans” and “Adult: 19+ years”. The search was conducted on 29 May 2021; (3) Results: a total of 357 references were identified from the bibliographic database searches; after applying the inclusion and exclusion criteria, a total of 11 valid studies were obtained for the review. Interventions could be categorised into (1) interventions related to lifestyle, physical activity, and dietary changes through education programmes, (2) interventions associated with lifestyle, physical activity, and dietary changes through the use of telemonitoring systems or self-help applications, (3) interventions tied to lifestyle, physical activity, and dietary changes through control and/or social network support groups, and (4) interventions linked to changes in the work environment, including behavioural change training and work environment training tasks. The meta-analysis demonstrated that the heterogeneity present when analysing the results for BMI was 72% (p < 0.01), which decreased to 0% (p = 0.57) when analysing the outcomes for weight, in which case the null hypothesis of homogeneity could be accepted. In all instances, the final summary of the effect was on the decreasing side for both BMI and BW; (4) Conclusions: Despite the high heterogeneity of the results reported, the trend shown in all cases indicates that the intervention methodologies implemented by empowering individuals through Web 2.0 technologies are positive in terms of the problem of overweight. Further implementation of novel strategies to support individuals is needed to overcome obesity, and, at least in the early studies, these strategies seem to be making the necessary change.
A Scoping Review of Nutritional Biomarkers Associated with Food Security
Authors: Krasnovsky Lev , Crowley Aidan P. , Naeem Fawaz , Wang Lucy S. , Wu Gary D. , Chao Ariana M.
Published: August 2023

Food insecurity affects more than 40 million individuals in the United States and is linked to negative health outcomes due, in part, to poor dietary quality. Despite the emergence of metabolomics as a modality to objectively characterize nutritional biomarkers, it is unclear whether food security is associated with any biomarkers of dietary quality. This scoping review aims to summarize studies that examined associations between nutritional biomarkers and food security, as well as studies that investigated metabolomic differences between people with and without food insecurity. PubMed, Embase, Scopus, and AGRICOLA were searched through August 2022 for studies describing food insecurity and metabolic markers in blood, urine, plasma, hair, or nails. The 78 studies included consisted of targeted assays quantifying lipids, dietary nutrients, heavy metals, and environmental xenobiotics as biochemical features associated with food insecurity. Among those biomarkers which were quantified in at least five studies, none showed a consistent association with food insecurity. Although three biomarkers of dietary quality have been assessed between food-insecure versus food-secure populations, no studies have utilized untargeted metabolomics to characterize patterns of small molecules that distinguish between these two populations. Further studies are needed to characterize the dietary quality profiles of individuals with and without food insecurity.
The Effect of Long Chain n-3 Fatty Acid Supplementation on Muscle Strength in Older Adults: A Systematic Review and Meta-Analysis
Authors: Timraz Maha , Binmahfoz Ahmad , Quinn Terry J. , Combet Emilie , Gray Stuart R.
Published: August 2023

The main objective of the current study was to perform a systematic literature review with the purpose of exploring the impact of long-chain n-3 polyunsaturated fatty acid (LCn-3 PUFA) relative to control oil supplementation on muscle strength, with secondary outcomes of muscle mass and physical function in older individuals under conditions of habitual physical activity/exercise. The review protocol was registered with PROSPERO (CRD42021267011) and followed the guidelines outlined in the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statement. The search for relevant studies was performed utilizing databases such as PubMed, EMBASE, CINAHL, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) up to June 2023. Randomized controlled trials (RCTs) in older adults comparing the effects of LCn-3 PUFA with a control oil supplement on muscle strength were included. Five studies involving a total of 488 participants (348 females and 140 males) were identified that met the specified inclusion criteria and were included. Upon analyzing the collective data from these studies, it was observed that supplementation with LCn-3 PUFA did not have a significant impact on grip strength (standardized mean difference (SMD) 0.61, 95% confidence interval [−0.05, 1.27]; p = 0.07) in comparison to the control group. However, there was a considerable level of heterogeneity among the studies (I2 = 90%; p < 0.001). As secondary outcomes were only measured in a few studies, with significant heterogeneity in methods, meta-analyses of muscle mass and functional abilities were not performed. Papers with measures of knee extensor muscle mass as an outcome (n = 3) found increases with LCn-3 PUFA supplementation, but studies measuring whole body lean/muscle mass (n = 2) and functional abilities (n = 4) reported mixed results. With a limited number of studies, our data indicate that LCn-3 PUFA supplementation has no effect on muscle strength or functional abilities in older adults but may increase muscle mass, although, with only a few studies and considerable heterogeneity, further work is needed to confirm these findings.
Increased Job Burnout and Reduced Job Satisfaction for Nurses Compared to Other Healthcare Workers after the COVID-19 Pandemic
Authors: Galanis Petros , Moisoglou Ioannis , Katsiroumpa Aglaia , Vraka Irene , Siskou Olga , Konstantakopoulou Olympia , Meimeti Evangelia , Kaitelidou Daphne
Published: August 2023

Nurses experience high levels of job burnout and low levels of job satisfaction, while the COVID-19 pandemic has deteriorated working conditions. In this context, our aim was to compare levels of job burnout and job satisfaction among nurses and other healthcare workers (HCWs) after the COVID-19 pandemic. Moreover, we investigated the influence of demographics and job characteristics on burnout and satisfaction. We conducted a cross-sectional study with 1760 HCWs during June 2023. We used the single-item burnout measure and the “Job Satisfaction Survey”. In our sample, 91.1% of nurses experienced high levels of burnout, while the respective percentage for the other HCWs was 79.9%. Nurses’ satisfaction was lower than other HCWs. In particular, 61.0% of nurses experienced low levels of satisfaction, while the respective percentage for the other HCWs was 38.8%. Multivariable analysis identified that nurses, HCWs with an MSc/PhD diploma, shift workers, and those who considered their workplace as understaffed had higher burnout score and lower satisfaction score. Our results showed that the nursing profession was an independent factor of burnout and satisfaction. Several other demographic and job characteristics affected burnout and satisfaction. Policy makers, organizations, and managers should adopt appropriate interventions to improve work conditions.
The Use of CBD and Its Synthetic Analog HU308 in HIV-1-Infected Myeloid Cells
Authors: Williams Anastasia , Khatkar Pooja , Branscome Heather , Kim Yuriy , Erickson James , Jenabian Mohammad-Ali , Costiniuk Cecilia T. , Kashanchi Fatah
Published: August 2023

Currently, there is no cure for human immunodeficiency virus type 1 (HIV-1) infection. However, combined antiretroviral therapy (cART) aids in viral latency and prevents the progression of HIV-1 infection into acquired immunodeficiency syndrome (AIDS). cART has extended many lives, but people living with HIV-1 (PLWH) face lifelong ailments such as HIV-associated neurocognitive disorders (HAND) that range from asymptomatic HAND to HIV-1-associated dementia. HAND has been attributed to chronic inflammation and low-level infection within the central nervous system (CNS) caused by proinflammatory cytokines and viral products. These molecules are shuttled into the CNS within extracellular vesicles (EVs), lipid bound nanoparticles, and are released from cells as a form of intercellular communication. This study investigates the impact of cannabidiol (CBD), as a promising and potential therapeutic for HAND patients, and a similar synthetic molecule, HU308, on the EVs released from HIV-1-infected myeloid cells as well as HIV-1-infected 3D neurospheres. The data shows that both CBD and HU308 decrease non-coding and coding viral RNA (TAR and env) as well as proinflammatory cytokines as IL-1β and TNF-α mRNA. This decrease in viral RNA occurs in in vitro differentiated primary macrophages, in EVs released from HIV-1-infected cells monocytes, and infected neurospheres. Furthermore, a 3D neurosphere model shows an overall decrease in proinflammatory mRNA with HU308. Finally, using a humanized mouse model of HIV-1 infection, plasma viral RNA was shown to significantly decrease with HU308 alone and was most effective in combination with cART, even when compared to the typical cART treatment. Overall, CBD or HU308 may be a viable option to decrease EV release and associated cytokines which would dampen the virus spread and may be used in effective treatment of HAND in combination with cART.
Nanostructured Lipid Carriers to Enhance the Bioavailability and Solubility of Ranolazine: Statistical Optimization and Pharmacological Evaluations
Authors: Unnisa Aziz , Chettupalli Ananda K. , Alazragi Reem S. , Alelwani Walla , Bannunah Azzah M. , Barnawi Jameel , Amarachinta Padmanabha R. , Jandrajupalli Suresh B. , Elamine Badria A. , Mohamed Omkalthoum A. , Hussain Talib
Published: August 2023

Chronic stable angina pectoris is the primary indication for ranolazine (RZ), an anti-anginal drug. The drug has an anti-ischemic action that is unaffected by either blood pressure or heart rate. Due to the first-pass effect, the drug has a reduced bioavailability of 35 to 50%. The study emphasized developing a novel transdermal drug delivery system of nanostructured lipid carriers (NLCs) for delivering RZ. Many pharmaceutical companies employ lipid nanoparticles as biocompatible carriers for medicinal, cosmetic, and biochemical uses. These carriers are appropriate for many applications, such as topical, transdermal, parenteral, pulmonary, and oral administration, because of the large variety of lipids and surfactants that are readily available for manufacturing. RZ NLCs were made using high-pressure homogenization. Statistical analysis was utilized to find the best formula by varying the concentrations of Precirol ATO 5 (X1), oleic acid (X2), and Tween 80 (X3). Variables such as entrapment effectiveness (EE) (Y1), particle size (Y2), polydispersity index (PDI) (Y3), and zeta potential (Y4) were tested. A variety of tests were performed on the new formulation to ascertain how well it would be absorbed in the body. These tests included in vivo absorption studies, skin permeability assessments, in vitro drug release assessments, and physicochemical analyses. The particle size of RZ-NLCs was shown to be very small (118.4 ± 5.94 nm), with improved EE (88.39 ± 3.1%) and low ZP and PDI (−41.91 ± 0.38 and 0.118 ± 0.028). SEM and TEM analysis confirmed the structure of the NLCs and showed a smooth, spherical surface. Improved RZ-NLCs were used to create NLC gel, which was then tested for elasticity both physically and rheologically. The formulation’s elasticity was investigated. Optimized RZ-NLCs and NLCG were found to have transdermal fluxes of 48.369 g/cm2/h and 38.383 g/cm2/h, respectively. These results showed that the transdermal delivery of RZ distribution through NLC’s transdermal gel had more significant potential. According to in vivo experiments, the drug’s bioavailability in Wistar rats increased when it was delivered through NLCs. The findings demonstrated that NLCs loaded with RZ successfully transported the RZ to the designated site with no interruptions and that a quadratic connection existed between the independent and dependent variables.
Development of Environmentally Responsive Self-Emulsifying System Containing Copaiba Oil-Resin for Leishmaniasis Oral Treatment
Authors: de Oliveira Mariana , Balbinot Rodolfo , Villa Nova Mônica , Gonçalves Renato , Bidóia Danielle , Caetano Wilker , Nakamura Celso , Bruschi Marcos
Published: August 2023

Leishmaniasis is a disease caused by protozoa species of the Leishmania genus, and the current treatments face several difficulties and obstacles. Most anti-leishmanial drugs are administered intravenously, showing many side effects and drug resistance. The discovery of new anti-leishmanial compounds and the development of new pharmaceutical systems for more efficient and safer treatments are necessary. Copaiba oil-resin (CO) has been shown to be a promising natural compound against leishmaniasis. However, CO displays poor aqueous solubility and bioavailability. Self-emulsifying drug delivery systems (SEDDS) can provide platforms for release of hydrophobic compounds in the gastrointestinal tract, improving their aqueous solubilization, absorption and bioavailability. Therefore, the present work aimed to develop SEDDS containing CO and Soluplus® surfactant for the oral treatment of leishmaniasis. The design of the systems was accomplished using ternary phase diagrams. Emulsification and dispersion time tests were used to investigate the emulsification process in gastric and intestinal environments. The formulations were nanostructured and improved the CO solubilization. Their in vitro antiproliferative activity against promastigote forms of L. amazonensis and L. infantum, and low in vitro cytotoxicity against macrophages were also observed. More studies are necessary to determine effectiveness of SOL in these systems, which can be candidates for further pharmacokinetics and in vivo investigations.
Driving Spray Drying towards Better Yield: Tackling a Problem That Sticks Around
Authors: Sundararajan Pavithra , Moser Justin , Williams Lisa , Chiang Tiffany , Riordan Colin , Metzger Matthew , Zhang-Plasket Fan , Wang Fang , Collins John , Williams Joseph
Published: August 2023

Powder deposition and accumulation on walls of spray drying chamber has been known to impact spray drying processes, resulting in lower yield, frequent shutdowns, and downtimes. Critical factors that impact the extent and rate of wall deposition have been studied extensively in the chemical and food industry. In this paper, we present an atypical process yield issue wherein acceptable yield is obtained during the first batch of spray drying but undergoes significant yield loss in consecutive batches. Through understanding the interplay of the process, material properties, and equipment, we identify key mechanisms that are playing a role in causing the process yield issue. These mechanisms include surface roughness of the inner wall of the spray dryer, variation in gas flow due to the introduction of process analytical technology, start-up and shutdown operating parameters that expose the wall deposited powder from the prior batch to temperatures close to the onset of glass transition temperature and cause depression of its glass transition temperature. These factors result in more wall accumulation and impact the yield in subsequent batches. By correcting for most of these factors, the yield reduction issue was mitigated, and processing efficiency was improved.
Analysis of the Self-Healing Capability of Thermoplastic Elastomer Capsules in a Polymeric Beam Structure Based on Strain Energy Release Behaviour during Crack Growth
Authors: Almutairi Mohammed Dukhi , He Feiyang , Alshammari Yousef Lafi , Alnahdi Sultan Saleh , Khan Muhammad Ali
Published: August 2023

The objective of this study was to investigate the elastic and plastic responses of 3D-printed thermoplastic elastomer (TPE) beams under various bending loads. The study also aimed to develop a self-healing mechanism using origami TPE capsules embedded within an ABS structure. These cross-shaped capsules have the ability to be either folded or elastically deformed. When a crack occurs in the ABS structure, the strain is released, causing the TPE capsule to unfold along the crack direction, thereby enhancing the crack resistance of the ABS structure. The enhanced ability to resist cracks was confirmed through a delamination test on a double cantilever specimen subjected to quasi-static load conditions. Consistent test outcomes highlighted how the self-healing process influenced the development of structural cracks. These results indicate that the suggested self-healing mechanism has the potential to be a unique addition to current methods, which mostly rely on external healing agents.
Hygromechanical Behavior of Polyamide 6.6: Experiments and Modeling
Authors: Wetzel Paul , Sambale Anna Katharina , Uhlig Kai , Stommel Markus , Schneider Benjamin , Kaiser Jan-Martin
Published: August 2023

This paper investigates water absorption in polyamide 6.6 and the resulting hygroscopic swelling and changes in mechanical properties. First, sorption and swelling experiments on specimens from injection molded plates are presented. The observed swelling behavior is dependent on the melt flow direction of the injection molding process. Additionally, thermal analysis and mechanical tensile tests were performed for different conditioning states. The water sorption is accompanied by a decrease in the glass transition temperature and a significant reduction in stiffness and strength. Next, a sequentially coupled modeling approach is presented. A nonlinear diffusion model is followed by mechanical simulations accounting for swelling and concentration-dependent properties. For the mechanical properties, the notion of a “gap” temperature caused by the shift of the glass transition range due to water-induced plasticization is employed. This model enables the computation of local moisture concentration fields and the resultant swelling and changes in stress–strain behavior.
A Visco-Hyperelastic Constitutive Model to Characterize the Stress-Softening Behavior of Ethylene Propylene Diene Monomer Rubber
Authors: Liu Xiu , Liu Chen , Zhu Dingxiang , Lin Jianguo
Published: August 2023

Uniaxial and biaxial cyclic tensile tests and stress relaxation tests were performed on the ethylene propylene diene monomer (EPDM) material to investigate its stress-softening effect. The experimental results reveal that the EPDM material presents a significant Mullins effect during the cyclic stretching processes. Furthermore, it is found that the deformation of the EPDM material does not return to zero simultaneously with the stress, due to the viscoelasticity of the EPDM material. Therefore, this study combines pseudo-elasticity theory and viscoelastic theory to propose a visco-hyperelastic constitutive model. The proposed model is used to fit and analyze the uniaxial and biaxial cyclic test results of EPDM and a comparison is conducted with the corresponding hyper-elastic constitutive model. The results show that the proposed model is in good agreement with the experimental data and superior to the hyper-elastic constitutive model, especially when it comes to the stress-softening unloading process. This work is conducive to accurately characterizing the stress-softening behavior of rubber-like materials at large deformation and can provide some theoretical guidance for their widespread application in industry.
Near-Infrared Light Triggered the Shape Memory Behavior of Polydopamine-Nanoparticle-Filled Epoxy Acrylate
Authors: Wang Qi , Yan Xuefeng , Liu Ping , Xu Yiyan , Guan Qingbao , You Zhengwei
Published: August 2023

Through the effective combination of photothermal conversion agent polydopamine (PDA) nanoparticles and epoxy acrylate polymer (EA), a new kind of near-infrared (NIR) light-triggered shape memory polymer (PDA/EA) is developed. Due to the outstanding photothermal effect of PDA, even with a very low concentration of PDA (0.1 wt.%), when exposed to an 808 nm NIR light with a power of 1 W/cm2, the temporary shapes can be fully light-responsive, recovered in 60 s. Based on dynamic thermomechanical analysis and thermal gravimetric analysis, it can be seen that the introduction of PDA is beneficial for improving dynamic mechanical properties and thermal resistance compared to EA. As an environmentally friendly and highly efficient photoactive SMP, PDA/EA has a great application prospect.
Investigating the Mechanical Properties of Annealed 3D-Printed PLA–Date Pits Composite
Authors: Fouly Ahmed , Albahkali Thamer , Abdo Hany S. , Salah Omar
Published: August 2023

Biomedical applications are crucial in rehabilitation medicine, assisting individuals with disabilities. Nevertheless, materials failure can sometimes result in inconvenience for users. Polylactic Acid (PLA) is a popular 3D-printed material that offers design flexibility. However, it is limited in use because its mechanical properties are inadequate. Thus, this study introduces an artificial intelligence model that utilizes ANFIS to estimate the mechanical properties of PLA composites. The model was developed based on an actual data set collected from experiments. The experimental results were obtained by preparing samples of PLA green composites with different weight fractions of date pits, which were then annealed for varying durations to remove residual stresses resulting from 3D printing. The mechanical characteristics of the produced PLA composite specimens were measured experimentally, while the ANSYS model was established to identify the composites’ load-carrying capacity. The results showed that ANFIS models are exceptionally robust and compatible and possess good predictive capabilities for estimating the hardness, strength, and Young’s modulus of the 3D-printed PLA composites. The model results and experimental outcomes were nearly identical.
Bonding Characteristics of Silane Coupling Agent and MMA-Containing Primer to Various Composite CAD/CAM Blocks
Authors: Asakura Masaki , Aimu Koki , Hayashi Tatsuhide , Matsubara Masakazu , Mieki Akimichi , Ban Seiji , Kawai Tatsushi
Published: August 2023

This study evaluated the bonding characteristics of a silane coupling agent (SCA) and a methyl methacrylate (MMA)-containing primer (MCP) for 11 types of commercial composite blocks (CBs) for sandblasted and non-sandblasted surfaces. The shear bond strength (SBS) was measured according to ISO 29022: Notched-edge shear bond strength test. The SBS results demonstrated statistically significant differences between the CBs under all identical conditions. For the non-sandblasted groups, the SBSs of MCP-treated specimens were significantly higher than those of SCA-treated specimens for all but two CBs. Comparing the two treatments in sandblasted groups, the SBS was significantly higher for seven out of 11 MCP-treated RCB specimens, in contrast with three cases for the SCA-treated group. Two-way ANOVA for SBS showed the interaction effect between sandblasting and primer type for specific CBs, indicating that the sandblasting treatment improved SBS more effectively for SCA-treated specimens. Moreover, the effect of the SCA treatment was more material-dependent compared to that of the MCP treatment, which did not achieve a strong bond in all CBs but proved more effective than the SCA treatment, especially for non-sandblasted surfaces.
Peripheral Nerve Regeneration at 1 Year: Biodegradable Polybutylene Succinate Artificial Scaffold vs. Conventional Epineurial Sutures
Authors: Cicero Luca , Puleio Roberto , Cassata Giovanni , Cirincione Roberta , Camarda Lawrence , Caracappa Dario , D’Itri Lorenzo , Licciardi Mariano , Vigni Giulio Edoardo
Published: August 2023

The utilization of a planar poly(1,4-butylene succinate) (PBS) scaffold has been demonstrated as an effective approach for preserving nerve continuity and facilitating nerve regeneration. In this study, we assessed the characteristics of a microfibrous tubular scaffold specifically designed and fabricated through electrospinning, utilizing PBS as a biocompatible and biodegradable material. These scaffolds were evaluated as nerve guide conduits in a rat model of sciatic nerve neurotmesis, demonstrating both their biodegradability and efficacy in enhancing the reconstruction process over a long-term period (1-year follow-up). Histological assay and electrophysiological evaluation were performed to compare the long-term outcomes following sutureless repair with the microfibrillar wrap to outcomes obtained using traditional suture repair.
Application of the NSGA-II Algorithm and Kriging Model to Optimise the Process Parameters for the Improvement of the Quality of Fresnel Lenses
Authors: Chang Hanjui , Sun Yue , Wang Rui , Lu Shuzhou
Published: August 2023

The Fresnel lens is an optical system consisting of a series of concentric diamond grooves. One surface of the lens is smooth, while the other is engraved with concentric circles of increasing size. Optical interference, diffraction, and sensitivity to the angle of incidence are used to design the microstructure on the lens surface. The imaging of the optical surface depends on its curvature. By reducing the thickness of the lens, light can still be focused at the same focal point as with a thicker lens. Previously, lenses, including Fresnel lenses, were made of glass due to material limitations. However, the traditional grinding and polishing methods for making Fresnel lenses were not only time-consuming, but also labour-intensive. As a result, costs were high. Later, a thermal pressing process using metal moulds was invented. However, the high surface tension of glass caused some detailed parts to be deformed during the pressing process, resulting in unsatisfactory Fresnel lens performance. In addition, the complex manufacturing process and unstable processing accuracy hindered mass production. This resulted in high prices and limited applications for Fresnel lenses. These factors prevented the widespread use of early Fresnel lenses. In contrast, polymer materials offer advantages, such as low density, light weight, high strength-to-weight ratios, and corrosion resistance. They are also cost effective and available in a wide range of grades. Polymer materials have gradually replaced optical glass and other materials in the manufacture of micro-optical lenses and other miniaturised devices. Therefore, this study focuses on investigating the manufacturing parameters of Fresnel lenses in the injection moulding process. We compare the quality of products obtained by two-stage injection moulding, injection compression moulding, and IMD (in-mould decoration) techniques. The results show that the optimal method is IMD, which reduces the nodal displacement on the Fresnel lens surface and improves the transmission performance. To achieve this, we first establish a Kriging model to correlate the process parameters with optimisation objectives, mapping the design parameters and optimisation objectives. Based on the Kriging model, we integrate the NSGA-II algorithm with the predictive model to obtain the Pareto optimal solutions. By analysing the Pareto frontier, we identify the best process parameters. Finally, it is determined that the average nodal displacement on the Fresnel surface is 0.393 mm, at a holding pressure of 320.35 MPa and a melt temperature of 251.40 °C. Combined with IMD technology, product testing shows a transmittance of 95.43% and an optimisation rate of 59.64%.
Study of Tangential Effusion Cooling of a Combustor Liner
Authors: Li Ziwan , Xie Pengfu , Zeng Qinghua , Chen Xuanwu
Published: August 2023

Tangential effusion cooling of a combustor liner has a large difference from traditional effusion cooling on a plate. In this paper, numerical simulation is carried out to study the flow field, heat transfer characteristics and the factors affecting the cooling effectiveness of tangential effusion cooling of a combustor liner. It is found that the cooling film formed by the tangential jet is distributed in a divergent “horsetail” shape and adheres tightly to the inner wall of the liner, which increases the cooling area and effectiveness. Three different tangential inlet cooling hole arrangements and their cooling efficiencies are studied, and several important parameters that affect the cooling effectiveness are summarized. Then, an improved cooling hole arrangement is proposed, and its cooling efficiency is studied and compared with those of the original three arrangements. The results show that the new arrangement significantly improves the comprehensive cooling efficiency and decreases the wall temperature, thus confirming the effectiveness of the improved strategy and providing a theoretical basis for the subsequent cooling design to improve the cooling efficiency for a combustor liner.
Numerical Study on High Throughput and High Solid Particle Separation in Deterministic Lateral Displacement Microarrays
Authors: Wullenweber Maike S. , Kottmeier Jonathan , Kampen Ingo , Dietzel Andreas , Kwade Arno
Published: August 2023

Deterministic lateral displacement (DLD) is a high-resolution passive microfluidic separation method for separating micron-scale particles according to their size. Optimizing these microsystems for larger throughputs and particle concentrations is of interest for industrial applications. This study evaluates the limitations of the functionality of the DLD separation principle under these specific conditions. For this reason, different particle volume fractions (up to 11%) and volumetric flow rates (corresponding to Reynolds numbers up to 50) were varied within the DLD microsystem and tested in different combinations. Resolved two-way coupled computational fluid dynamics/discrete element method (CFD-DEM) simulations including spherical particles were performed. The results show a general increase in the critical diameter with increasing volume fraction and decreasing separation efficiency. The largest tested Reynolds number (Re = 50) results in the highest separation efficiency, particularly at low volume fractions, and is only slightly less efficient than low Reynolds numbers as the volume fraction increases. The results indicate that by limiting the volume fraction to a maximum of 3.6%, the flow rate and the associated separation rate can be increased while maintaining a high separation efficiency.
Optimization Study of Inert Gas Distribution for Multiple-Bay Fuel Tank
Authors: Shao Lei , He Jiawei , Lu Xia , Liu Weihua
Published: August 2023

Inert gas distribution has a great influence on the inerting effect, especially for the multiple-bay fuel tank. In order to find out the optimal scheme, an optimization method based on the entropy-weight improvement TOPSIS method is proposed, and an experimental system of inert gas distribution is established to measure the speed index and uniformity index. The results show that the position of the inlet and outlet has a significant effect on the overall inerting effect. The inerting scheme designed by the entropy-weight improvement TOPSIS method can not only reduce the flow demand of inert gas but also make the oxygen distribution more uniform. The optimization inerting scheme of the Boeing 747 aircraft has improved the average speed index by 3.01% and the average uniformity index by 26.18%. The smoke visualization experiment also showed that the scheme designed by the entropy-weight improvement TOPSIS method has the denser white smoke, which means that the scheme has better performance.
NIODA and the Problem of Evil: God as Ultimate Determiner
Authors: Sánchez-Cañizares Javier
Published: August 2023

The problem of evil permeates contemporary theodicy, raising the question of how an omnipotent and benevolent God can allow its existence. Exploring this inquiry is inherently tied to investigating divine action, specifically the interplay between time and eternity within a temporary creation. In recent decades, the Non-Interventionist Objective Divine Action (NIODA) project has endeavored to present a science-backed perspective that acknowledges a respectful divine action harmonizing with the workings of nature. However, this viewpoint has faced criticism from various angles, particularly for its perceived inability to provide a definitive response to the problem of evil. This contribution aims to overcome these criticisms. While not necessarily endorsing the NIODA proposal, it seeks to present a fresh outlook on the question of evil that aligns with NIODA, addressing the dichotomy between the unity and plurality of divine action in the world and offering novel insights for the Christian doctrine of creation.
An Islamic Perspective on Infection Treatment and Wound Healing
Authors: Ali Tajwar , Sultan Haseena
Published: August 2023

Muslims regard Islam as a complete code of conduct because it provides guidance in all aspects of life. Islamic teachings cover nearly all areas of knowledge, including medical sciences. Islam offers a unique perspective on how to treat wounds and illnesses. Islamic wound treatment methods are distinct and recognized by modern science. For Muslims, the only true treatment for illnesses and injuries is that mentioned in the Holy Quran and practiced by the Holy Prophet himself throughout his lifetime. Islamic treatments for various internal and external wounds and illnesses, such as the use of honey, black cumin, Indian incense, cupping, and cauterization, are extremely beneficial in treating both internal and external wounds. Islamic diets are high in beneficial nutrients for the body, such as ginger, figs, dates, and olive oil, and Islamic rituals such as five daily prayers, ablution, and fasting are very effective at keeping the body wound resistant. A healthy body has a strong immune system that can fight off various illnesses and injuries. To reach a definitive conclusion, a thorough examination of Islam’s original and fundamental sources, such as the Holy Quran and the sayings of the Holy Prophet, was carried out. Although modern science has validated the majority of the approaches emphasized by Islamic teachings, much more research is needed to validate Islamic sayings about medical sciences.
Mapping Underwater Aquatic Vegetation Using Foundation Models With Air- and Space-Borne Images: The Case of Polyphytos Lake
Authors: Alagialoglou Leonidas , Manakos Ioannis , Papadopoulou Sofia , Chadoulis Rizos-Theodoros , Kita Afroditi
Published: August 2023

Mapping underwater aquatic vegetation (UVeg) is crucial for understanding the dynamics of freshwater ecosystems. The advancement of artificial intelligence (AI) techniques has shown great potential in improving the accuracy and efficiency of UVeg mapping using remote sensing data. This paper presents a comparative study of the performance of classical and modern AI tools, including logistic regression, random forest, and a visual-prompt-tuned foundational model, the Segment Anything model (SAM), for mapping UVeg by analyzing air- and space-borne images in the few-shot learning regime, i.e., using limited annotations. The findings demonstrate the effectiveness of the SAM foundation model in air-borne imagery (GSD = 3–6 cm) with an F1 score of 86.5%±4.1% when trained with as few as 40 positive/negative pairs of pixels, compared to 54.0%±9.2% using the random forest model and 42.8%±6.2% using logistic regression models. However, adapting SAM to space-borne images (WorldView-2 and Sentinel-2) remains challenging, and could not outperform classical pixel-wise random forest and logistic regression methods in our task. The findings presented provide valuable insights into the strengths and limitations of AI models for UVeg mapping, aiding researchers and practitioners in selecting the most suitable tools for their specific applications.