bluuebunny/crossref_metadata_2025 huggingface dataset:
Density Self-Adaptive Hybrid Clustering Routing Protocol for Wireless Sensor Networks
Authors: Ye Ting , Wang Baowei
Published: June 2016

Energy efficiency is of major concern in wireless sensor networks, especially in difficult node deployment environments. Clustering is an effective method to save energy consumption and prolong the network lifetime. There are two kinds of clustering methods in hierarchical routing protocols, namely distributed control and centralized control. In the distributed strategy, the algorithm has good scalability, but it can easily lead to an uneven distribution of cluster heads. When the centralized strategy is used, the network is balanced and robust, but the overhead of clustering is large and the network latency is increased. In our proposed protocol, named DAHC, a mixture algorithm of distributed and centralized control is used to select a cluster head (CH). Simultaneously, we propose a novel approach to judge the cluster density and adjust according to the preset threshold. The simulation results show that our methods can evenly distribute the energy load on all nodes, save the energy consumption of communication and extend the network lifetime concurrently.
Ergodic Inequality
Authors: Norman Thomas
Published: June 2016

Weak conditions are provided under which society’s long-run distribution of wealth is independent of initial asset holdings.
Capturing Interactive Occupation and Social Engagement in a Residential Dementia and Mental Health Setting Using Quantitative and Narrative Data
Authors: Morgan-Brown Mark , Brangan Joan
Published: June 2016

Objectives: Despite an abundance of research acknowledging the value of interactive occupation and social engagement for older people, and the limits to these imposed by many residential settings, there is a lack of research which measures and analyzes these concepts. This research provides a method for measuring, analysing and monitoring interactive occupation and social engagement levels of residents in a secure residential setting for older people with mental health problems and dementia. It proposes suggestions for changes to improve the well-being of residents in residential settings. Method: In this case study design, the Assessment Tool for Occupational and Social Engagement (ATOSE) provided a ‘whole room’ time sampling technique to observe resident and staff interactive occupation and social engagement within the communal sitting room over a five-week period. Researchers made contemporaneous notes to supplement the ATOSE data and to contextualise the observations. Results: Residents in the sitting room were passive, sedentary, and unengaged for 82.73% of their time. Staff, who were busy and active 98.84% of their time in the sitting room, spent 43.39% of this time in activities which did not directly engage the residents. The physical, social and occupational environments did not support interactive occupation or social engagement. Conclusions: The ATOSE assessment tool, in combination with narrative data, provides a clear measurement and analysis of interactive occupation and social engagement in this and other residential settings. Suggestions for change include a focus on the physical, social, occupational, and sensory environments and the culture of care throughout the organization.
Environmental Light and Its Relationship with Electromagnetic Resonances of Biomolecular Interactions, as Predicted by the Resonant Recognition Model
Authors: Cosic Irena , Cosic Drasko , Lazar Katarina
Published: June 2016

The meaning and influence of light to biomolecular interactions, and consequently to health, has been analyzed using the Resonant Recognition Model (RRM). The RRM proposes that biological processes/interactions are based on electromagnetic resonances between interacting biomolecules at specific electromagnetic frequencies within the infra-red, visible and ultra-violet frequency ranges, where each interaction can be identified by the certain frequency critical for resonant activation of specific biological activities of proteins and DNA. We found that: (1) the various biological interactions could be grouped according to their resonant frequency into super families of these functions, enabling simpler analyses of these interactions and consequently analyses of influence of electromagnetic frequencies to health; (2) the RRM spectrum of all analyzed biological functions/interactions is the same as the spectrum of the sun light on the Earth, which is in accordance with fact that life is sustained by the sun light; (3) the water is transparent to RRM frequencies, enabling proteins and DNA to interact without loss of energy; (4) the spectrum of some artificial sources of light, as opposed to the sun light, do not cover the whole RRM spectrum, causing concerns for disturbance to some biological functions and consequently we speculate that it can influence health.
Modulation of PPAR Expression and Activity in Response to Polyphenolic Compounds in High Fat Diets
Authors: Domínguez-Avila J. , González-Aguilar Gustavo , Alvarez-Parrilla Emilio , De la Rosa Laura
Published: June 2016

Peroxisome proliferator-activated receptors (PPAR) are transcription factors that modulate energy metabolism in liver, adipose tissue and muscle. High fat diets (HFD) can negatively impact PPAR expression or activity, favoring obesity, dyslipidemia, insulin resistance and other conditions. However, polyphenols (PP) found in vegetable foodstuffs are capable of positively modulating this pathway. We therefore focused this review on the possible effects that PP can have on PPAR when administered together with HFD. We found that PP from diverse sources, such as coffee, olives, rice, berries and others, are capable of inducing the expression of genes involved in a decrease of adipose mass, liver and serum lipids and lipid biosynthesis in animal and cell models of HFD. Since cells or gut bacteria can transform PP into different metabolites, it is possible that a synergistic or antagonistic effect ultimately occurs. PP molecules from vegetable sources are an interesting option to maintain or return to a state of energy homeostasis, possibly due to an adequate PPAR expression and activity.
The NAD-Dependent Deacetylase Sirtuin-1 Regulates the Expression of Osteogenic Transcriptional Activator Runt-Related Transcription Factor 2 (Runx2) and Production of Matrix Metalloproteinase (MMP)-13 in Chondrocytes in Osteoarthritis
Authors: Terauchi Koh , Kobayashi Hajime , Yatabe Kanaka , Yui Naoko , Fujiya Hiroto , Niki Hisateru , Musha Haruki , Yudoh Kazuo
Published: June 2016

Aging is one of the major pathologic factors associated with osteoarthritis (OA). Recently, numerous reports have demonstrated the impact of sirtuin-1 (Sirt1), which is the NAD-dependent deacetylase, on human aging. It has been demonstrated that Sirt1 induces osteogenic and chondrogenic differentiation of mesenchymal stem cells. However, the role of Sirt1 in the OA chondrocytes still remains unknown. We postulated that Sirt1 regulates a hypertrophic chondrocyte lineage and degeneration of articular cartilage through the activation of osteogenic transcriptional activator Runx2 and matrix metalloproteinase (MMP)-13 in OA chondrocytes. To verify whether sirtuin-1 (Sirt1) regulates chondrocyte activity in OA, we studied expressions of Sirt1, Runx2 and production of MMP-13, and their associations in human OA chondrocytes. The expression of Sirt1 was ubiquitously observed in osteoarthritic chondrocytes; in contrast, Runx2 expressed in the osteophyte region in patients with OA and OA model mice. OA relating catabolic factor IL-1βincreased the expression of Runx2 in OA chondrocytes. OA chondrocytes, which were pretreated with Sirt1 inhibitor, inhibited the IL-1β-induced expression of Runx2 compared to the control. Since the Runx2 is a promotor of MMP-13 expression, Sirt1 inactivation may inhibit the Runx2 expression and the resultant down-regulation of MMP-13 production in chondrocytes. Our findings suggest thatSirt1 may regulate the expression of Runx2, which is the osteogenic transcription factor, and the production of MMP-13 from chondrocytes in OA. Since Sirt1 activity is known to be affected by several stresses, including inflammation and oxidative stress, as well as aging, SIRT may be involved in the development of OA.
Mechanisms Underlying Activation of α1-Adrenergic Receptor-Induced Trafficking of AQP5 in Rat Parotid Acinar Cells under Isotonic or Hypotonic Conditions
Authors: Bragiel Aneta , Wang Di , Pieczonka Tomasz , Shono Masayuki , Ishikawa Yasuko
Published: June 2016

Defective cellular trafficking of aquaporin-5 (AQP5) to the apical plasma membrane (APM) in salivary glands is associated with the loss of salivary fluid secretion. To examine mechanisms of α1-adrenoceptor (AR)-induced trafficking of AQP5, immunoconfocal microscopy and Western blot analysis were used to analyze AQP5 localization in parotid tissues stimulated with phenylephrine under different osmolality. Phenylephrine-induced trafficking of AQP5 to the APM and lateral plasma membrane (LPM) was mediated via the α1A-AR subtype, but not the α1B- and α1D-AR subtypes. Phenylephrine-induced trafficking of AQP5 was inhibited by ODQ and KT5823, inhibitors of nitric oxide (NO)-stimulated guanylcyclase (GC) and protein kinase (PK) G, respectively, indicating the involvement of the NO/ soluble (c) GC/PKG signaling pathway. Under isotonic conditions, phenylephrine-induced trafficking was inhibited by La3+, implying the participation of store-operated Ca2+ channel. Under hypotonic conditions, phenylephrine-induced trafficking of AQP5 to the APM was higher than that under isotonic conditions. Under non-stimulated conditions, hypotonicity-induced trafficking of AQP5 to the APM was inhibited by ruthenium red and La3+, suggesting the involvement of extracellular Ca2+ entry. Thus, α1A-AR activation induced the trafficking of AQP5 to the APM and LPM via the Ca2+/ cyclic guanosine monophosphate (cGMP)/PKG signaling pathway, which is associated with store-operated Ca2+ entry.
Use of Different Proteases to Obtain Flaxseed Protein Hydrolysates with Antioxidant Activity
Authors: Karamać Magdalena , Kosińska-Cagnazzo Agnieszka , Kulczyk Anna
Published: June 2016

The antioxidant activity of flaxseed protein hydrolysates obtained using five different enzymes was evaluated. Proteins were isolated from flaxseed cake and were separately treated with papain, trypsin, pancreatin, Alcalase and Flavourzyme. The degree of hydrolysis (DH) was determined as the percentage of cleaved peptide bonds using a spectrophotometric method with o-phthaldialdehyde. The distribution of the molecular weights (MW) of the hydrolysis products was profiled using Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis (Tricine-SDS-PAGE) and size exclusion-high performance liquid chromatography (SE-HPLC) separations. The antioxidant activities of the protein isolate and hydrolysates were probed for their radical scavenging activity using 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonate) radical cation (ABTS•+) and photochemiluminescence (PCL-ACL) assays, and for their ferric reducing antioxidant power (FRAP) and ability to bind Fe2+. The hydrolysates were more effective as antioxidants than the protein isolate in all systems. The PCL-ACL values of the hydrolysates ranged from 7.2 to 35.7 μmol Trolox/g. Both the FRAP and ABTS•+ scavenging activity differed among the hydrolysates to a lower extent, with the ranges of 0.20–0.24 mmol Fe2+/g and 0.17–0.22 mmol Trolox/g, respectively. The highest chelating activity (71.5%) was noted for the pancreatin hydrolysate. In general, the hydrolysates obtained using Alcalase and pancreatin had the highest antioxidant activity, even though their DH (15.4% and 29.3%, respectively) and the MW profiles of the peptides varied substantially. The O2•− scavenging activity and the ability to chelate Fe2+ of the Flavourzyme hydrolysate were lower than those of the Alcalase and pancreatin hydrolysates. Papain was the least effective in releasing the peptides with antioxidant activity. The study showed that the type of enzyme used for flaxseed protein hydrolysis determines the antioxidant activity of the hydrolysates.
A WDR Gene Is a Conserved Member of a Chitin Synthase Gene Cluster and Influences the Cell Wall in Aspergillus nidulans
Authors: Guerriero Gea , Silvestrini Lucia , Obersriebnig Michael , Hausman Jean-Francois , Strauss Joseph , Ezcurra Inés
Published: June 2016

WD40 repeat (WDR) proteins are pleiotropic molecular hubs. We identify a WDR gene that is a conserved genomic neighbor of a chitin synthase gene in Ascomycetes. The WDR gene is unique to fungi and plants, and was called Fungal Plant WD (FPWD). FPWD is within a cell wall metabolism gene cluster in the Ascomycetes (Pezizomycotina) comprising chsD, a Chs activator and a GH17 glucanase. The FPWD, AN1556.2 locus was deleted in Aspergillus nidulans strain SAA.111 by gene replacement and only heterokaryon transformants were obtained. The re-annotation of Aspergilli genomes shows that AN1556.2 consists of two tightly linked separate genes, i.e., the WDR gene and a putative beta-flanking gene of unknown function. The WDR and the beta-flanking genes are conserved genomic neighbors localized within a recently identified metabolic cell wall gene cluster in genomes of Aspergilli. The heterokaryons displayed increased susceptibility to drugs affecting the cell wall, and their phenotypes, observed by optical, confocal, scanning electron and atomic force microscopy, suggest cell wall alterations. Quantitative real-time PCR shows altered expression of some cell wall-related genes. The possible implications on cell wall biosynthesis are discussed.
Heart Failure: Diagnosis, Management and Utilization
Authors: Inamdar Arati , Inamdar Ajinkya
Published: June 2016

Despite the advancement in medicine, management of heart failure (HF), which usually presents as a disease syndrome, has been a challenge to healthcare providers. This is reflected by the relatively higher rate of readmissions along with increased mortality and morbidity associated with HF. In this review article, we first provide a general overview of types of HF pathogenesis and diagnostic features of HF including the crucial role of exercise in determining the severity of heart failure, the efficacy of therapeutic strategies and the morbidity/mortality of HF. We then discuss the quality control measures to prevent the growing readmission rates for HF. We also attempt to elucidate published and ongoing clinical trials for HF in an effort to evaluate the standard and novel therapeutic approaches, including stem cell and gene therapies, to reduce the morbidity and mortality. Finally, we discuss the appropriate utilization/documentation and medical coding based on the severity of the HF alone and with minor and major co-morbidities. We consider that this review provides an extensive overview of the HF in terms of disease pathophysiology, management and documentation for the general readers, as well as for the clinicians/physicians/hospitalists.
A Review of Glass-Ionomer Cements for Clinical Dentistry
Authors: Sidhu Sharanbir , Nicholson John
Published: June 2016

This article is an updated review of the published literature on glass-ionomer cements and covers their structure, properties and clinical uses within dentistry, with an emphasis on findings from the last five years or so. Glass-ionomers are shown to set by an acid-base reaction within 2–3 min and to form hard, reasonably strong materials with acceptable appearance. They release fluoride and are bioactive, so that they gradually develop a strong, durable interfacial ion-exchange layer at the interface with the tooth, which is responsible for their adhesion. Modified forms of glass-ionomers, namely resin-modified glass-ionomers and glass carbomer, are also described and their properties and applications covered. Physical properties of the resin-modified glass-ionomers are shown to be good, and comparable with those of conventional glass-ionomers, but biocompatibility is somewhat compromised by the presence of the resin component, 2 hydroxyethyl methacrylate. Properties of glass carbomer appear to be slightly inferior to those of the best modern conventional glass-ionomers, and there is not yet sufficient information to determine how their bioactivity compares, although they have been formulated to enhance this particular feature.
The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Highlights on Recent Papers in Joint Biomechanics of Running
Authors: Szychlinska Marta , Castorina Sergio , Lorenzetti Silvio , Di Giunta Angelo , Vaz João , Dickin Clark
Published: June 2016

We are glad to introduce the second Journal Club. On the occasion of the recent Global Running Day, the first of June 2016, the second edition is focused on several relevant studies published recently in the field of Joint Biomechanics of Running, chosen by our Scientific Board members. We hope to stimulate your curiosity in this field and to share with you the passion for the sport seen also from the scientific point of view. The Editorial Board members wish you an inspiring lecture.
Strengthening the Voice of Persons with Mental Health Problems in Legal Capacity Proceedings
Authors: Fallon-Kund Marie , Bickenbach Jerome
Published: June 2016

Despite the standards set out by the United Nations Convention on the Rights of Persons with Disabilities (CRPD), states are reluctant to put an end to substitute decision-making regimes all at once. Persons with mental health problems are particularly affected by such regimes that are instituted by independent authorities through legal capacity proceedings. In order to allow the person to express their will and preferences throughout the proceedings, the right to be heard is of primary importance for the person concerned. The objective of this paper is to review the essential support mechanisms as well as procedural accommodations for the implementation of an equal and effective right to be heard for persons with mental health problems. Fulfilling the right to be heard in legal capacity proceedings is a step towards more individualized regimes that promote the autonomy of the person.
Optimization of Supercritical Fluid Extraction of Total Alkaloids, Peimisine, Peimine and Peiminine from the Bulb of Fritillaria thunbergii Miq, and Evaluation of Antioxidant Activities of the Extracts
Authors: Ruan Xiao , Yang Li , Cui Wen-Xia , Zhang Men-Xing , Li Zhao-Hui , Liu Ben , Wang Qiang
Published: June 2016

Supercritical fluid extraction (SFE) was used to extract total alkaloids, peimisine, peimine and peiminine from the bulb of Fritillaria thunbergii Miq. The antioxidant capacity of the extracts was evaluated by DPPH radical scavenging activity (DPPH-RSA), ABTS radical scavenging activity (ABTS-RSA) and ferric reducing capacity (FRAP) assay. A central composite design (CCD) with four variables and five levels was employed for optimization of process parameters, and response surface plots were constructed in accordance with a second order polynomial model. Under optimal conditions of 3.0 h, 60.4 °C, 26.5 MPa and 89.3% ethanol, the highest yields were predicted to be 3.8 mg/g for total alkaloids, 0.5 mg/g for peimisine, 1.3 mg/g for peimine and 1.3 mg/g for peiminine, and the antioxidant capacity of extracts displayed EC50, DPPH value of 5.5 mg/mL, EC50, ABTS value of 0.3 mg/mL and FRAP value of 118.2 mg ascorbic acid equivalent (AAE)/100 g.
Influence of Rubber Size on Properties of Crumb Rubber Mortars
Authors: Yu Yong , Zhu Han
Published: June 2016

Studies on the properties and applications of rubber cement-based materials are well documented. The sizes of rubbers used in these materials varied. However, information about the effects of rubber size on the properties of rubber cement-based materials, especially pore structure, mechanical strengths, and drying shrinkage properties, remains limited. Three groups of rubber with major particle sizes of 2–4 mm, 1–3 mm, and 0–2 mm were selected in this study. This paper presents experimental studies on the effects of rubber size on the consistency, fresh density, pore structure, mechanical properties, and drying shrinkage properties of crumb rubber mortars (CRMs). Results demonstrated that the consistency and fresh density of CRMs decreased with the rubber size. As to the pore structure, the total pore volume increased with the decrease of the rubber size. By contrast, the influence of the rubber size on the mesopore (<50 nm) volume is not as significant as that of the rubber content. The mechanical properties of CRMs decreased with the rubber size. Low rubber stiffness and large pore volumes, especially those of small sized rubbers, contribute to the reduction of CRMs strength. The drying shrinkage of CRM increases as the rubber size decreases. The influences of rubber size on capillary tension are not significant. Thus, the shrinkage increases with the decrease of rubber size mainly because of its function in the deformation modulus reduction of CRMs.
Hard-Rock Stability Analysis for Span Design in Entry-Type Excavations with Learning Classifiers
Authors: García-Gonzalo Esperanza , Fernández-Muñiz Zulima , García Nieto Paulino , Bernardo Sánchez Antonio , Menéndez Fernández Marta
Published: June 2016

The mining industry relies heavily on empirical analysis for design and prediction. An empirical design method, called the critical span graph, was developed specifically for rock stability analysis in entry-type excavations, based on an extensive case-history database of cut and fill mining in Canada. This empirical span design chart plots the critical span against rock mass rating for the observed case histories and has been accepted by many mining operations for the initial span design of cut and fill stopes. Different types of analysis have been used to classify the observed cases into stable, potentially unstable and unstable groups. The main purpose of this paper is to present a new method for defining rock stability areas of the critical span graph, which applies machine learning classifiers (support vector machine and extreme learning machine). The results show a reasonable correlation with previous guidelines. These machine learning methods are good tools for developing empirical methods, since they make no assumptions about the regression function. With this software, it is easy to add new field observations to a previous database, improving prediction output with the addition of data that consider the local conditions for each mine.
Exact Discrete Analogs of Canonical Commutation and Uncertainty Relations
Authors: Tarasov Vasily
Published: June 2016

An exact discretization of the canonical commutation and corresponding uncertainty relations are suggested. We prove that the canonical commutation relations of discrete quantum mechanics, which is based on standard finite difference, holds for constant wave functions only. In this paper, we use the recently proposed exact discretization of derivatives, which is based on differences that are represented by infinite series. This new mathematical tool allows us to build sensible discrete quantum mechanics based on the suggested differences and includes the correct canonical commutation and uncertainty relations.
Examination of Solubility Models for the Determination of Transition Metals within Liquid Alkali Metals
Authors: Isler Jeremy , Zhang Jinsuo
Published: June 2016

The experimental solubility of transition metals in liquid alkali metal was compared to the modeled solubility calculated using various equations for solubility. These equations were modeled using the enthalpy calculations of the semi-empirical Miedema model and various entropy calculations. The accuracy of the predicted solubility compared to the experimental data is more dependent on which liquid alkali metal is being examined rather than the transition metal solute examined. For liquid lithium the calculated solubility by the model was generally larger than experimental values, while for liquid cesium the modeling solubility was significantly smaller than the experimental values. For liquid sodium, potassium, and rubidium the experimental solubilities were within the range calculated by this study. Few data approached the predicted temperature dependence of solubility and instead most data exhibited a less pronounced temperature dependence.
Creep Aging Behavior Characterization of 2219 Aluminum Alloy
Authors: Liu Lingfeng , Zhan Lihua , Li Wenke
Published: June 2016

In order to characterize the creep behaviors of 2219 aluminum alloy at different temperatures and stress levels, a RWS-50 Electronic Creep Testing Machine (Zhuhai SUST Electrical Equipment Company, Zhuhai, China) was used for creep experiment at temperatures of 353~458 k and experimental stresses of 130~170 MPa. It was discovered that this alloy displayed classical creep curve characteristics in its creep behaviors within the experimental parameters, and its creep value increased with temperature and stress. Based on the creep equation of hyperbolic sine function, regression analysis was conducted of experimental data to calculate stress exponent, creep activation energy, and other related variables, and a 2219 aluminum alloy creep constitutive equation was established. Results of further analysis of the creep mechanism of the alloy at different temperatures indicated that the creep mechanism of 2219 aluminum alloy differed at different temperatures; and creek characteristics were presented in three stages at different temperatures, i.e., the grain boundary sliding creep mechanism at a low temperature stage (T < 373 K), the dislocation glide creep mechanism at a medium temperature stage (373 K ≤ T < 418 K), and the dislocation climb creep mechanism at a high temperature stage (T ≥ 418 K). By comparative analysis of the fitting results and experiment data, they were found to be in agreement with the experimental data, revealing that the established creep constitutive equation is suitable for different temperatures and stresses.
Activating and Attenuating the Amicoumacin Antibiotics
Authors: Park Hyun , Perez Corey , Perry Elena , Crawford Jason
Published: June 2016

The amicoumacins belong to a class of dihydroisocoumarin natural products and display antibacterial, antifungal, anticancer, and anti-inflammatory activities. Amicoumacins are the pro-drug activation products of a bacterial nonribosomal peptide-polyketide hybrid biosynthetic pathway and have been isolated from Gram-positive Bacillus and Nocardia species. Here, we report the stimulation of a “cryptic” amicoumacin pathway in the entomopathogenic Gram-negative bacterium Xenorhabdus bovienii, a strain not previously known to produce amicoumacins. X. bovienii participates in a multi-lateral symbiosis where it is pathogenic to insects and mutualistic to its Steinernema nematode host. Waxmoth larvae are common prey of the X. bovienii-Steinernema pair. Employing a medium designed to mimic the amino acid content of the waxmoth circulatory fluid led to the detection and characterization of amicoumacins in X. bovienii. The chemical structures of the amicoumacins were supported by 2D-NMR, HR-ESI-QTOF-MS, tandem MS, and polarimeter spectral data. A comparative gene cluster analysis of the identified X. bovienii amicoumacin pathway to that of the Bacillus subtilis amicoumacin pathway and the structurally-related Xenorhabdus nematophila xenocoumacin pathway is presented. The X. bovienii pathway encodes an acetyltransferase not found in the other reported pathways, which leads to a series of N-acetyl-amicoumacins that lack antibacterial activity. N-acetylation of amicoumacin was validated through in vitro protein biochemical studies, and the impact of N-acylation on amicoumacin’s mode of action was examined through ribosomal structural analyses.
Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
Authors: Fattori Victor , Hohmann Miriam , Rossaneis Ana , Pinho-Ribeiro Felipe , Verri Waldiceu
Published: June 2016

In this review, we discuss the importance of capsaicin to the current understanding of neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We will focus on the analgesic effects of capsaicin and its clinical applicability in treating pain. Furthermore, we will draw attention to the rationale for other clinical therapeutic uses and implications of capsaicin in diseases such as obesity, diabetes, cardiovascular conditions, cancer, airway diseases, itch, gastric, and urological disorders.
In Silico Mining for Antimalarial Structure-Activity Knowledge and Discovery of Novel Antimalarial Curcuminoids
Authors: Viira Birgit , Gendron Thibault , Lanfranchi Don , Cojean Sandrine , Horvath Dragos , Marcou Gilles , Varnek Alexandre , Maes Louis , Maran Uko , Loiseau Philippe , Davioud-Charvet Elisabeth
Published: June 2016

Malaria is a parasitic tropical disease that kills around 600,000 patients every year. The emergence of resistant Plasmodium falciparum parasites to artemisinin-based combination therapies (ACTs) represents a significant public health threat, indicating the urgent need for new effective compounds to reverse ACT resistance and cure the disease. For this, extensive curation and homogenization of experimental anti-Plasmodium screening data from both in-house and ChEMBL sources were conducted. As a result, a coherent strategy was established that allowed compiling coherent training sets that associate compound structures to the respective antimalarial activity measurements. Seventeen of these training sets led to the successful generation of classification models discriminating whether a compound has a significant probability to be active under the specific conditions of the antimalarial test associated with each set. These models were used in consensus prediction of the most likely active from a series of curcuminoids available in-house. Positive predictions together with a few predicted as inactive were then submitted to experimental in vitro antimalarial testing. A large majority from predicted compounds showed antimalarial activity, but not those predicted as inactive, thus experimentally validating the in silico screening approach. The herein proposed consensus machine learning approach showed its potential to reduce the cost and duration of antimalarial drug discovery.
Beneficial Effect of Synbiotic Supplementation on Hepatic Steatosis and Anthropometric Parameters, But Not on Gut Permeability in a Population with Nonalcoholic Steatohepatitis
Authors: Ferolla Silvia , Couto Cláudia , Costa-Silva Luciana , Armiliato Geyza , Pereira Cristiano , Martins Flaviano , Ferrari Maria , Vilela Eduardo , Torres Henrique , Cunha Aloísio , Ferrari Teresa
Published: June 2016

Nonalcoholic fatty liver disease is the most prevalent chronic liver disease in Western countries; it can progress to nonalcoholic steatohepatitis (NASH), cirrhosis and hepatocarcinoma. The importance of gut-liver-adipose tissue axis has become evident and treatments targeting gut microbiota may improve inflammatory and metabolic parameters in NASH patients. In a randomized, controlled clinical trial, involving 50 biopsy-proven NASH patients, we investigated the effects of synbiotic supplementation on metabolic parameters, hepatic steatosis, intestinal permeability, small intestinal bacterial overgrowth (SIBO) and lipopolysaccharide (LPS) serum levels. Patients were separated into two groups receiving Lactobacillus reuteri with guar gum and inulin for three months and healthy balanced nutritional counseling versus nutritional counseling alone. Before and after the intervention we assessed steatosis by magnetic resonance imaging, intestinal permeability by lactulose/mannitol urinary excretion and SIBO by glucose breath testing. NASH patients presented high gut permeability, but low prevalence of SIBO. After the intervention, only the synbiotic group presented a reduction in steatosis, lost weight, diminished BMI and waist circumference measurement. Synbiotic did not improve intestinal permeability or LPS levels. We concluded that synbiotic supplementation associated with nutritional counseling seems superior to nutritional counseling alone for NASH treatment as it attenuates steatosis and may help to achieve weight loss.
Leucine-Enriched Essential Amino Acids Augment Mixed Protein Synthesis, But Not Collagen Protein Synthesis, in Rat Skeletal Muscle after Downhill Running
Authors: Kato Hiroyuki , Suzuki Hiromi , Inoue Yoshiko , Suzuki Katsuya , Kobayashi Hisamine
Published: June 2016

Mixed and collagen protein synthesis is elevated for as many as 3 days following exercise. Immediately after exercise, enhanced amino acid availability increases synthesis of mixed muscle protein, but not muscle collagen protein. However, the potential for synergic effects of amino acid ingestion with exercise on both mixed and collagen protein synthesis remains unclear. We investigated muscle collagen protein synthesis in rats following post-exercise ingestion of leucine-enriched essential amino acids. We determined fractional protein synthesis rates (FSR) at different time points following exercise. Mixed protein and collagen protein FSRs in skeletal muscle were determined by measuring protein-bound enrichments of hydroxyproline and proline, and by measuring the intracellular enrichment of proline, using injections of flooding d3-proline doses. A leucine-enriched mixture of essential amino acids (or distilled water as a control) was administrated 30 min or 1 day post-exercise. The collagen protein synthesis in the vastus lateralis was elevated for 2 days after exercise. Although amino acid administration did not increase muscle collagen protein synthesis, it did lead to augmented mixed muscle protein synthesis 1 day following exercise. Thus, contrary to the regulation of mixed muscle protein synthesis, muscle collagen protein synthesis is not affected by amino acid availability after damage-inducing exercise.
Strategies to Overcome Heparins’ Low Oral Bioavailability
Authors: Neves Ana , Correia-da-Silva Marta , Sousa Emília , Pinto Madalena
Published: June 2016

Even after a century, heparin is still the most effective anticoagulant available with few side effects. The poor oral absorption of heparins triggered the search for strategies to achieve oral bioavailability since this route has evident advantages over parenteral administration. Several approaches emerged, such as conjugation of heparins with bile acids and lipids, formulation with penetration enhancers, and encapsulation of heparins in micro and nanoparticles. Some of these strategies appear to have potential as good delivery systems to overcome heparin’s low oral bioavailability. Nevertheless, none have reached the market yet. Overall, this review aims to provide insights regarding the oral bioavailability of heparin.
Review of Bionanocomposite Coating Films and Their Applications
Authors: Mhd Haniffa Mhd , Ching Yern , Abdullah Luqman , Poh Sin , Chuah Cheng
Published: June 2016

The properties of a composite material depend on its constituent materials such as natural biopolymers or synthetic biodegradable polymers and inorganic or organic nanomaterials or nano-scale minerals. The significance of bio-based and synthetic polymers and their drawbacks on coating film application is currently being discussed in research papers and articles. Properties and applications vary for each novel synthetic bio-based material, and a number of such materials have been fabricated in recent years. This review provides an in-depth discussion on the properties and applications of biopolymer-based nanocomposite coating films. Recent works and articles are cited in this paper. These citations are ubiquitous in the development of novel bionanocomposites and their applications.
Towards an Existential Archeology of Capitalist Spirituality
Authors: González George
Published: June 2016

Throughout his career, Michel Foucault sustained a trenchant critique of Jean-Paul Sartre, whom he accused of arguing that the subject “dispenses (all) significations”. In contrast to existentialism’s interests in subjective consciousness, Foucault pursues an archaeological method which he later develops into a genealogical approach to discourse that emphasizes the institutional practices and forms of knowledge/power that undergird historical epistemes. Taking contemporary networked Capitalism, the discourse of “workplace spirituality”, and the life history of one management reformer as its case studies, this paper turns to the cognitive linguistics of George Lakoff and Mark Johnson in an effort to historicize experiences of neoliberal “spirituality”, as an archaeology of knowledge might, while also attempting to account for intentionality and biography, as existential approaches would. Turning to work in contemporary critical theory, which associates strident anti-humanism in social theory with the rise of neoliberal discourse, I argue that sustained attention to the ways in which personal and social history always entail one another and are mutually arising makes not only for better phenomenology but makes for better critical scholarship as well.
In-Orbit Radiometric Calibration and Stability Monitoring of the PROBA-V Instrument
Authors: Sterckx Sindy , Adriaensen Stefan , Dierckx Wouter , Bouvet Marc
Published: June 2016

Since its launch in May 2013, the in-orbit radiometric performance of PROBA-V has been continuously monitored. Due to the absence of on-board calibration devices, in-flight performance monitoring and calibration relies fully on vicarious calibration methods. In this paper, the multiple vicarious calibration techniques used to verify radiometric accuracy and to perform calibration parameter updates are discussed. Details are given of the radiometric calibration activities during both the commissioning and operational phase. The stability of the instrument in terms of overall radiometry and dark current is analyzed. Results of an independent comparison against MERIS and SPOT VEGETATION-2 are presented. Finally, an outlook is provided of the on-going activities aimed at improving both data consistency over time and within-scene uniformity.
Discrimination between Ground Vegetation and Small Pioneer Trees in the Boreal-Alpine Ecotone Using Intensity Metrics Derived from Airborne Laser Scanner Data
Authors: Næsset Erik
Published: June 2016

It has been shown that height measurements obtained by airborne laser scanning (ALS) with high point density (>7–8 m−2) can be used to detect small trees in the alpine tree line—an ecotone sensitive to climate change. Because the height measurements do not discriminate between trees and other convex structures with positive height values, this study aimed at assessing the contribution of ALS backscatter intensity to classification of trees and non-trees. The study took place in a boreal-alpine ecotone in southeastern Norway and was based on 500 precisely georeferenced small trees and non-tree objects for which ALS height and intensity were derived from four different ALS acquisitions, representing different sensors, pulse repetition frequencies (PRF), and flying altitudes. The sensors operated at 1064 nm. Based on logistic regression modeling, it was found that classification into three different tree species ((1) spruce; (2) pine; and (3) birch)) and two different non-tree object types (objects with: (1) vegetated surface; and (2) rock) was significantly better (p < 0.001–0.05) than a classification based on models with trees and non-trees as binary response. The cause of the improved classification is mainly diverse reflectivity properties of non-tree objects. No effect of sensor, PRF, and flying altitude was found (p > 0.05). Finally, it was revealed that in a direct comparison of the contribution of intensity backscatter to improve classification models of trees and non-trees beyond what could be obtained by using the ALS height information only, the contribution of intensity turned out to be far from significant (p > 0.05). In conclusion, ALS backscatter intensity seems to be of little help in classification of small trees and non-trees in the boreal-alpine ecotone even when a more detailed discrimination on different species and different non-tree structures is applied.
Microcantilever Displacement Measurement Using a Mechanically Modulated Optical Feedback Interferometer
Authors: Azcona Francisco , Jha Ajit , Yáñez Carlos , Atashkhooei Reza , Royo Santiago
Published: June 2016

Microcantilever motion detection is a useful tool for the characterization of the physical, chemical and biological properties of materials. In the past, different approaches have been proposed and tested to enhance the behavior, size and simplicity of microcantilever motion detectors. In this paper, a new approach to measure microcantilever motion with nanometric resolution is presented. The proposed approach is based on the concept of mechanically-modulated optical feedback interferometry, a technique that has shown displacement measurement capabilities well within the nanometric scale and that, due to its size, compactness and low cost, may be a suitable choice for measuring nanometric motions in cantilever-like sensors. It will be shown that the sensor, in its current state of development, is capable of following a cantilever sinusoidal trajectory at different sets of frequencies ranging up to 200 Hz and peak to peak amplitudes up to λ / 2 with experimental resolutions in the λ / 100 range.
An Enhanced Technique for Ultrasonic Flow Metering Featuring Very Low Jitter and Offset
Authors: Hamouda Assia , Manck Otto , Hafiane Mohamed , Bouguechal Nour-Eddine
Published: June 2016

This paper proposes a new, improved method for water flow metering. It applies to a transit time ultrasonic flow meter device. In principle, the flow of a given liquid in a pipe is obtained by measuring the transit times of an ultrasonic wave in the upstream and downstream directions. The difference between these times is, in theory, linearly proportional to the liquid flow velocity. However, the fainter the flow is, the smaller the transit time difference (TTD) is. This difference can be as low as a few picoseconds, which gives rise to many technical difficulties in measuring such a small time difference with a given accuracy. The proposed method relies on measuring the TTD indirectly by computing the phase difference between the steady-state parts of the received signals in the upstream and downstream directions and by using a least-square-sine-fitting technique. This reduces the effect of the jitter noise and the offset, which limit measurement precision at very low flow velocity. The obtained measurement results illustrate the robustness of the proposed method, as we measure the TTD at no-flow conditions, with a precision as low as 10 ps peak-to-peak and a TTD offset of zero, within a temperature range from room temperature to 80 °C. This allows us to reach a smaller minimum detectable flow when compared with previous techniques. The proposed method exhibits a better trade-off between measurement accuracy and system complexity. It can be completely integrated in an ASIC (application specific integrated circuit) or incorporated in a CPU- or micro-controller-based system.
Do Robots Need to Be Stereotyped? Technical Characteristics as a Moderator of Gender Stereotyping
Authors: Dufour Florian , Ehrwein Nihan Céline
Published: June 2016

As suggested by previous results, whether, when designing robots, we should make use of social stereotypes and thus perpetuate them is question of present concern. The aim of this study was the identification of the specific conditions under which people’s judgments of robots were no longer guided by stereotypes. The study participants were 121 individuals between 18 and 69 years of age. We used an experimental design and manipulated the gender and strength of robots, and we measured the perception of how a robot could be used in automotive mechanics for light and heavy tasks. Results show that the technical characteristics of robots helped to anchor people’s judgments on robots’ intrinsic characteristics rather than on stereotypical indicators. Thus, stereotype perpetuation does not seem to be the sole option when designing robots.
Effects of Intermittent Neck Cooling During Repeated Bouts of High-Intensity Exercise
Authors: Galpin Andrew , Bagley James , Whitcomb Blake , Wiersma Leonard , Rosengarten Jakob , Coburn Jared , Judelson Daniel
Published: June 2016

The purpose of this investigation was to determine the influence of intermittent neck cooling during exercise bouts designed to mimic combat sport competitions. Participants (n = 13, age = 25.3 ± 5.0 year height = 176.9 ± 7.5 cm, mass = 79.3 ± 9.0 kg, body fat = 11.8% ± 3.1%) performed three trials on a cycle ergometer. Each trial consisted of two, 5-min high-intensity exercise (HEX) intervals (HEX1 and HEX2—20 s at 50% peak power, followed by 15 s of rest), and a time to exhaustion (TTE) test. One-minute rest intervals were given between each round (RI1 and RI2), during which researchers treated the participant’s posterior neck with either (1) wet-ice (ICE); (2) menthol spray (SPRAY); or (3) no treatment (CON). Neck (TNECK) and chest (TCHEST) skin temperatures were significantly lower following RI1 with ICE (vs. SPRAY). Thermal sensation decreased with ICE compared to CON following RI1, RI2, TTE, and a 2-min recovery. Rating of perceived exertion was also lower with ICE following HEX2 (vs. CON) and after RI2 (vs. SPRAY). Treatment did not influence TTE (68.9 ± 18.9s). The ability of intermittent ICE to attenuate neck and chest skin temperature rises during the initial HEX stages likely explains why participants felt cooler and less exerted during equivalent HEX bouts. These data suggest intermittent ICE improves perceptual stress during short, repeated bouts of vigorous exercise.
The Quest for Rural Sustainability in Russia
Authors: Wegren Stephen
Published: June 2016

Rural depopulation and the disappearance of villages in rural Russia occurred as part of the historical process of urbanization and industrialization. Rural depopulation also occurred for structural reasons having to do with village location, and for behavioral reasons whereby villagers react to primitive living conditions and poor economic prospects. Three possible strategies for addressing the problem of sustainable villages are considered. The government is attempting to improve rural living conditions, but rural depopulation is likely to continue. Characteristics of sustainable villages are outlined. Agro-tourism is analyzed for its potential to support sustainable villages.
Is Tourism Development a Sustainable Economic Growth Strategy in the Long Run? Evidence from GCC Countries
Authors: Alhowaish Abdulkarim
Published: June 2016

The main objective of this study is to investigate the causal relationship between tourism development and economic growth in Gulf Cooperation Council (GCC) countries in a multivariate model, using panel data for the period 1995–2012. The study adopts a panel Granger causality analysis approach to assess the contribution of tourism to economic growth in GCC countries as a whole, and in each individual country. In the case of GCC countries as a whole, the results show a one-way Granger causality, from economic growth to tourism growth. Furthermore, Kuwait, Saudi Arabia, Qatar, and the United Arab Emirates follow the path of economy-driven tourism growth, as hypothesized. The reverse hypothesis (i.e., tourism-led growth hypothesis) holds true for Bahrain, while there is no causal relationship between tourism and economic growth in the case of Oman.