bluuebunny/crossref_metadata_2025 huggingface dataset:
Parameter inference with analytical propagators for stochastic models of autoregulated gene expression
Authors: Veerman Frits , Popović Nikola , Marr Carsten
Published: April 2021

Stochastic gene expression in regulatory networks is conventionally modelled via the chemical master equation (CME). As explicit solutions to the CME, in the form of so-called propagators, are oftentimes not readily available, various approximations have been proposed. A recently developed analytical method is based on a separation of time scales that assumes significant differences in the lifetimes of mRNA and protein in the network, allowing for the efficient approximation of propagators from asymptotic expansions for the corresponding generating functions. Here, we showcase the applicability of that method to simulated data from a ‘telegraph’ model for gene expression that is extended with an autoregulatory mechanism. We demonstrate that the resulting approximate propagators can be applied successfully for parameter inference in the non-regulated model; moreover, we show that, in the extended autoregulated model, autoactivation or autorepression may be refuted under certain assumptions on the model parameters. These results indicate that our approach may allow for successful parameter inference and model identification from longitudinal single cell data.
The idiodynamic method: willingness to communicate and anxiety processes interacting in real time
Authors: MacIntyre Peter D. , Gregersen Tammy
Published: April 2021

The idiodynamic method is a relatively new mixed-method approach to studying in real time the complex dynamics of integrated affective and cognitive states that interact continuously with human communication. The method requires video recording a sample of communication from a research participant and then using specialized software to play the video back while collecting contemporaneous self-reported ratings (approximately one per second) on one or more focal variables of interest to the researcher, such as willingness to communicate (WTC) or communication anxiety (CA). After the participant rates the communication sample, a continuous graph of changes in the focal variable is printed. The final step is to interview the speaker to gather an explanation for changes in the ratings, for example at peaks or valleys in the graph. The method can also collect observer ratings that can then be compared with the speaker’s self-ratings. To date, studies have been conducted examining WTC, CA, motivation, perceived competence, teacher self-efficacy, teacher empathy, and strategy use, among other topics. The strengths and limitations of the method will be discussed and a specific example of its use in measuring WTC and CA will be provided.
Argument Mining on Twitter: A survey
Authors: Schaefer Robin , Stede Manfred
Published: April 2021

In the last decade, the field of argument mining has grown notably. However, only relatively few studies have investigated argumentation in social media and specifically on Twitter. Here, we provide the, to our knowledge, first critical in-depth survey of the state of the art in tweet-based argument mining. We discuss approaches to modelling the structure of arguments in the context of tweet corpus annotation, and we review current progress in the task of detecting argument components and their relations in tweets. We also survey the intersection of argument mining and stance detection, before we conclude with an outlook.
Bone density and bone health alteration in boys with Duchenne Muscular Dystrophy: a prospective observational study
Authors: Suthar Renu , Reddy B. V. Chaithanya , Malviya Manisha , Sirari Titiksha , Attri Savita Verma , Patial Ajay , Tageja Minni , Didwal Gunjan , Khandelwal Niranjan K. , Saini Arushi G. , Saini Lokesh , Sahu Jitendra K. , Dayal Devi , Sankhyan Naveen
Published: April 2021

Objectives

Boys with Duchenne Muscular Dystrophy (DMD) are at increased risk for compromised bone health, manifesting as low-impact trauma long bone fractures and vertebral compression fractures.

Methods

In a prospective observational study, we studied bone health parameters in North Indian boys with DMD. We consecutively enrolled ambulatory boys with DMD on glucocorticoid therapy. Bone health was evaluated with X-ray spine, Dual-energy X-ray absorptiometry (DXA), serum calcium, vitamin D3 (25[OH]D), 1,25-dihyroxyvitamin D3 (1,25[OH]2D3), serum osteocalcin, osteopontin, and N terminal telopeptide of type 1 collagen (Ntx) levels.

Results

A total of 76 boys with DMD were enrolled. The median age was 8.5 (interquartile range [IQR] 7.04–10.77) years. Among these, seven (9.2%) boys had long bone fractures, and four (5.3%) had vertebral compression fractures. Fifty-four (71%) boys underwent DXA scan, and among these 31 (57%) had low bone mineral density (BMD, ≤−2 z-score) at the lumbar spine. The mean BMD z-score at the lumbar spine was −2.3 (95% confidence interval [CI] = −1.8, −2.8), and at the femoral neck was −2.5 (95% CI = −2, −2.9). 25(OH)D levels were deficient in 68 (89.5%, n=76) boys, and 1,25(OH)2D3 levels were deficient in all. Mean serum osteocalcin levels were 0.68 ± 0.38 ng/mL (n=54), serum osteopontin levels were 8.6 ± 4.6 pg/mL (n=54) and serum Ntx levels were 891 ± 476 nmol/L (n=54). Boys with low BMD received glucocorticoids for longer duration, in comparison to those with normal BMD (median, IQR [16.9 (6–34) months vs. 7.8 (4.8–13.4) months]; p=0.04).

Conclusions

Bone health is compromised in North Indian boys with DMD. BMD at the lumbar spine is reduced in more than half of boys with DMD and nearly all had vitamin D deficiency on regular vitamin D supplements. Longer duration of glucocorticoid therapy is a risk factor for low BMD in our cohort.
Propofol postpones colorectal cancer development through circ_0026344/miR-645/Akt/mTOR signal pathway
Authors: Cui Xiaomin , Feng Jiying , Wu Jian , Zhang Xiaobao , Ding Mengyao
Published: April 2021

Colorectal cancer (CRC) is responsible for thousands of slow and painful annual deaths. Propofol, an anesthetic, is commonly used in CRC surgery. The role of circularRNA0026344 (circ_0026344) in propofol-treated CRC remains unclear, which was further explored in this study. Real-time polymerase chain reaction (qPCR) was used to detect the expression of circ_0026344 and microRNA645 (miR-645) in CRC cells and normal cells. Western blot was devoted to testing the protein expression of phospho-protein kinase B (p-AKT), AKT, phospho-mammalian target of rapamycin (p-mTOR), and mTOR in CRC cells. Moreover, cell counting kit-8 (CCK8), colony formation, flow cytometry, and transwell assays were employed to assess the proliferation, apoptosis, and metastasis in CRC cells. Circinteractome online tool was applied to predict the combination between circ_0026344 and miR-645, which was further verified by dual-luciferase reporter system. circ_0026344 was lowly expressed and miR-645 was abundantly expressed in CRC cells. The relative protein expression of p-AKT/AKT and p-mTOR/mTOR was strikingly elevated by si-circ#1, which could be reversed by anti-miR-645 in propofol-treated CRC cells. circ_0026344 overexpression inhibited the proliferation and metastasis and promoted apoptosis in CRC cells. Propofol treatment induced the restraint in proliferation and metastasis and stimulation in apoptosis, which were allayed by si-circ#1; meanwhile, this alleviation could further be abolished by anti-miR-645 in CRC cells. Furthermore, circ_0026344 sponged miR-645 to inhibited Akt/mTOR signal pathway in propofol-treated CRC cells. Propofol postponed CRC process by circ_0026344/miR-645/Akt/mTOR axis. This finding might provide a possibility to improve the therapy of CRC with propofol.
COVID-19 severity in relation to sociodemographics and vitamin D use
Authors: Abdulateef Darya Saeed , Rahman Heshu Sulaiman , Salih Jamal Mahmood , Osman Sangar Mahmoud , Mahmood Trifa Abdalla , Omer Shirwan Hama Salih , Ahmed Rana Adnan
Published: April 2021

Most COVID-19 cases are treated as outpatients, while the majority of studies on COVID-19 focus on inpatients. Little is known about the self-reporting and self-rating of the disease’s symptoms, and the associations of prophylactic use of dietary supplements with COVID-19 severity have not been addressed. The aims of this study are to evaluate COVID-19 severity and to relate them to sociodemographic characteristics and prophylactic dietary supplements. An observational patient-based study conducted through an online questionnaire on recovered COVID-19 patients. The patients were assessed for several severity parameters, sociodemographic parameters, and prophylactic dietary supplement use. A total of 428 patients were evaluated. Age and presence of comorbidities had positive associations with the severity parameters. The severe infection group had the highest proportion of patients stressed about COVID-19 (P < 0.05). Cigarette, but not hookah, smoking was significantly associated with less severe symptoms. Vitamin D negatively predicted disease severity (P < 0.05). In conclusion, stress, age, and presence of comorbidities were the most important positive predictors of COVID-19 severity, while prophylactic vitamin D use and smoking were significant negative predictors. The use of protective measures and other prophylactic dietary supplements was not significantly associated with symptom severity.
The crystal structure of 6,6′-((1E,1′E)-hydrazine-1,2-diylidenebis(methaneylylidene)) bis(2-bromo-4-nitrophenol) — dimethylsulfoxide (1/2), C14H8Br2N4O6⋅2(C2H6OS)
Authors: Ma Ling , Yang Ruoqi , Li Jianqing
Published: April 2021

C14H8Br2N4O6⋅2(C2H6OS), triclinic,

P

1
‾

$P\bar{1}$

(no. 2), a = 6.1463(12) Å, b = 8.3637(16) Å, c = 12.461(3) Å, α = 85.578(5)°, β = 85.942(5)°, γ = 86.310(5)°, V = 635.9(2) Å3, Z = 1, R

gt
(F) = 0.0601, wR

ref
(F
2) = 0.0983, T = 296 K.

CCDC no.: 2057510
The crystal structure of methyl 4-(1H-naphtho[1,8-de][1,3,2]diazaborinin-2(3H)-yl)benzoate, C18H15BN2O2
Authors: Ren Huaping , Miao Zong-Cheng
Published: April 2021

C18H15BN2O2, monoclinic, P21/c (no. 14), a = 6.8522(9) Å, b = 8.4333(11) Å, c = 13.1908(18) Å, β = 95.880(5)°, V = 758.24(17) Å3, Z = 2, R

gt
(F) = 0.0381, wR

ref
(F
2) = 0.1068, T = 193 K.

CCDC no.: 2045109
Crystal structure of N′, N‴-((propane-2,2-diylbis(1H-pyrrole-5,2-diyl))bis (methaneylylidene))di(picolinohydrazide) – water – methanol (1/1/1), C25H24N8O2·H2O·CH3OH
Authors: Xiong Ying , An Ya
Published: April 2021

C26H30N8O4, triclinic,

P

1
‾

$P‾{1}$

(no. 2), a = 8.0277(6) Å, b = 11.1460(10) Å, c = 15.8921(13) Å, α = 99.439(3)°, β = 102.525(3)°, γ = 95.309(3)°, V = 1357.17(19) Å3, Z = 2, R
gt(F) = 0.0442, wR
ref(F
2) = 0.1167, T = 273 K.
Nanostructured multifunctional electrocatalysts for efficient energy conversion systems: Recent perspectives
Authors: Rahman Sheikh Tareq , Rhee Kyong Yop , Park Soo-Jin
Published: April 2021

Electrocatalysts play a significant performance in renewable energy conversion, supporting several sustainable methods for future technologies. Because of the successful fabrication of distinctive oxygen reduction reaction (ORR), oxygen evolution reaction (OER), and hydrogen evolution reaction (HER) electrocatalysts, bifunctional ORR/OER and HER/OER electrocatalysts have become a hot area of contemporary research. ORR, OER, and HER have gained considerable attention because of their strong performance in different energy conversion and storage devices, including water-splitting devices, fuel cells, and metal–air rechargeable batteries. Therefore, the development of effective nanostructured multifunctional electrocatalysts for ORR, OER, and HER is necessary; and there is a demand for their industrialization for sustainable energy technology. In this review, details of current improvements in multifunctional catalysts for ORR/OER as well as HER/OER are presented, focusing on insight into the theoretical considerations of these reactions through investigation and estimation of different multifunctional catalysts. By analyzing the universal principles for various electrochemical reactions, we report a systematic scheme to clarify the recent trends in catalyzing these reactions over various types of nanostructure catalysts. The relevant reaction pathways and the related activity details for these reactions in the current literature are also included. Overall, the current demands and future outlines for improving the prospects of multifunctional electrocatalysts are discussed.
Effect of MnO
x
modification and template type on the catalytic performance of ceria-zirconia in CO and soot oxidation
Authors: Kaplin Igor Yu. , Lokteva Ekaterina S. , Bataeva Svetlana V. , Maslakov Konstantin I. , Fionov Alexander V. , Shumyantsev Alexey V. , Isaikina Oksana Ya. , Kamaev Alexey O. , Golubina Elena V.
Published: April 2021

The effect of the template nature and modification with MnO
x
on the catalytic efficiency of Ce0.8Zr0.2O2 (CZ) in oxidation of CO (2 vol% CO and 1 vol% O2 in He, pulse feeding) and soot particles (tight contact between soot and catalyst, TGA/DSC) was analyzed. The CZ catalysts were prepared using the CTAB and sawdust (SD) templates and modified with Mn (8 wt%) by wet impregnation followed by calcination at 400 °С. SEM-EDS, XRD, Raman and photoelectron spectroscopy, N2 adsorption, EPR, TPR-H2 and catalytic tests results demonstrated better catalytic activity of CZ(SD) in CO oxidation than of CZ(CTAB) because of the biomorphic texture, higher structural defectiveness and improved oxygen mobility of the former catalyst. Low surface reducibility and low concentration of active oxygen species on the CZ(SD) surface deteriorated its catalytic efficiency in the topochemical reaction of soot oxidation. Despite the different structure and degree of interaction between MnO
x
and CZ, the Mn-modified catalysts showed the similar catalytic properties: much better than of both unmodified catalysts in CO oxidation and worse than of CZ(CTAB) in soot oxidation. Mn2+ ions incorporated better into the surface layer of CZ(SD) than of CZ(CTAB), for which the inhomogeneous distribution of MnO
x
and decreased specific surface area were observed.
The Pursuit of Parmenidean Clarity
Authors: Bryan Jenny
Published: April 2021

This paper reconsiders the debates around the interpretation of Parmenides’ Being, in order to draw out the preconceptions that lie behind such debates and to scrutinize the legitimacy of applying them to a text such as Parmenides’ poem. With a focus on the assumptions that have driven scholars to seek clarity within the notoriously ambiguous verse of the poem, I ask whether it is possible to develop an analysis of Parmenides’ Being that is sympathetic both to his clear interest in argument, logic, knowledge and truth and to his ambiguous expression and cultural and literary resonances.
Sleep disturbance in patients attending specialized chronic pain clinics in Denmark: a longitudinal study examining the relationship between sleep and pain outcomes
Authors: Vaegter Henrik Bjarke , Høybye Mette Terp , Bergen Frederik Hjorth , Parsons Christine E.
Published: April 2021

Objectives

Sleep disturbances are highly prevalent in patients with chronic pain. However, the majority of studies to date examining sleep disturbances in patients with chronic pain have been population-based cross-sectional studies. The aims of this study were to 1) examine the frequency of sleep disturbances in patients referred to two interdisciplinary chronic pain clinics in Denmark, 2) explore associations between sleep disturbances and pain intensity, disability and quality of life at baseline and follow-up, and 3) explore whether changes in sleep quality mediated the relationships between pain outcomes at baseline and pain outcomes at follow-up.

Methods

We carried out a longitudinal observational study, examining patients enrolled in two chronic pain clinics assessed at baseline (n=2,531) and post-treatment follow-up (n=657). Patients reported on their sleep disturbances using the sleep quality subscale of the Karolinska Sleep Questionnaire (KSQ), their pain intensity using 0–10 numerical rating scales, their pain-related disability using the Pain Disability Index (PDI), and quality of life using the EuroQol-VAS scale. The average time between baseline and follow-up was 207 days (SD=154).

Results

At baseline, the majority of patients reported frequent sleep disturbances. We found a significant association at baseline between self-reported sleep disturbances and pain intensity, pain-related disability, and quality of life, where greater sleep disturbance was associated with poorer outcomes. At follow-up, patients reported significant improvements across all pain and sleep outcomes. In two mediation models, we showed that changes in sleep disturbances from baseline to follow-up were significantly associated with (i) pain intensity at follow-up, and (ii) pain disability at follow-up. However, baseline pain intensity and disability scores were not associated with changes in sleep disturbances and, we did not find evidence for significant mediation of either pain outcome by changes in sleep disturbances.

Conclusions

Self-reported sleep disturbances were associated with pain outcomes at baseline and follow-up, with greater sleep disturbances associated with poorer pain outcomes. Changes in sleep quality did not mediate the relationships between baseline and follow-up scores for pain intensity and disability. These findings contribute to a growing body of evidence confirming an association between sleep and chronic pain experience, particularly suggestive of a sleep to pain link. Our data following patients after interdisciplinary treatment suggests that improved sleep is a marker for a better outcome after treatment.
Research on quasi-one-dimensional modeling and performance analysis of RBCC propulsion system
Authors: Zhang Dong , Cheng Feng , Tang Shuo , Gong Chun-lin , Xu Bin
Published: April 2021

Quasi-one-dimensional model is the most effective way to realize the rapid iterative design of the overall scheme and control system of RBCC aircraft and has become a research hotspot. In the current research, the quasi-one-dimensional model of RBCC propulsion system is simplified. The model does not include physical characteristics such as wall heat transfer, boundary layer change, specific heat ratio change and transonic flow singularity, which makes the accuracy of the model low and cannot adapt to flight control in large airspace. A RBCC model with high accuracy and adaptability to wide-speed fly is established in this paper. Firstly, based on the laws of kinetic energy conservation and energy conservation, the thrust model of ejection mode is established. Secondly, the quasi-one-dimensional flow control equation is deduced, and the physical mechanism models of core flow area, transonic flow, pre-combustion shock train, heat release law and mixing efficiency are established. On this basis, the quasi-one-dimensional flow model of RBCC dual-mode ramjet is established. Thirdly, based on the law of momentum conservation, the mathematical model of rocket mode is deduced, and the thrust model of rocket mode is established. Finally, the accuracy of the quasi-one-dimensional model is verified by CFD numerical simulation and direct-connect experiment. Taking a typical RBCC launch vehicle as an example, the wide-speed performance of the RBCC propulsion system is calculated and analyzed.
Exergy Analysis of a Turboprop Engine at Different Flight Altitude and Speeds Using Novel Consideration
Authors: Dinc Ali , Gharbia Yousef
Published: April 2021

In this study, exergy efficiency calculations of a turboprop engine were performed together with main performance parameters such as shaft power, specific fuel consumption, fuel flow, thermal efficiency etc., for a range of flight altitude (0–14 km) and flight speeds (0–0.6 Mach). A novel exergy efficiency formula was derived in terms of specific fuel consumption and it is shown that these two parameters are inversely proportional to each other. Moreover, a novel exergy efficiency and thermal efficiency relation was also derived. The relationship showed that these two parameters are linearly proportional to each other. Exergy efficiency of the turboprop engine was found to be in the range of 23–33%. Thermal efficiency of the turboprop engine was found to be around 25–35%. Exergy efficiency is higher at higher speeds and altitude where the specific fuel consumption is lower. Conversely, exergy efficiency of the engine is lower for lower speeds and altitude where the specific fuel consumption is higher.
Study on inversion control for integrated helicopter/engine system with variable rotor speed based on state variable model
Authors: Wang Yong , Zheng Qiangang , Zhang Haibo , Chen Haoying
Published: April 2021

In order to realize the fast response control for turboshaft engine with variable rotor speed, a dynamic inversion (DI) control method based on state variable model of turboshaft engine is proposed. Meanwhile, in order to expand the application of dynamic inversion controller, the linear parameter varying (LPV) model of turboshaft engine is applied, which constitutes the LPV/DI controller together. The simulation results shows that compared with the conventional PID controller, the LPV/DI controller can effectively reduce the overshoot/droop of the power turbine speed to less than 1% under different flight conditions. The control effect is remarkable and the robust performance is superior.
Experimental research on the performance of the forward variable area bypass injector for variable cycle engines
Authors: Zhang Binglong , Liu He , Zhou Jianhua , Liu Hui
Published: April 2021

The forward variable area bypass injector (FVABI) is a key component of double bypass variable cycle engine (VCE) to achieve mode transition and bypass ratio adjustment. In this paper, an experimental system for FVABI was constructed based on the analysis of relevant experimental theories, and then the experiments on FVABI were carried out for a specific working state in double bypass mode of VCE and for the comparison working states with different area ratios and different back pressure ratios. The results showed that the FVABI designed in this paper meets the requirements of VCE at this working state. The analysis of the influence of area ratio and back pressure ratio on the injection coefficient showed that the first bypass valve and back pressure were effective means to control the mass flow of FVABI.
An active fault-tolerant control strategy of aircraft engines based on multi-model predictive control
Authors: Du Xian , Ma Yan-Hua
Published: April 2021

In order to mitigate or even eliminate the adverse effects caused by typical components faults of aircraft engines, an active fault-tolerant strategy based on multi-model predictive control is proposed, which consists of a pre-established multi-model library, a judgement module, and corresponding predictive controllers with smooth transition switching logic. Multiple dynamic nonlinear or linear models are firstly established by means of system identification methods, based on the component-level nonlinear engine model or historical data in faults cases. The judgement module is utilized to online compare the engine measured outputs with that of all models in the pattern library and select the best matched dynamic model on the basis of outputs error quadratic performance index, thus determining the most appropriate predictive controller for the next control sample period. When a certain fault occurs, the fault model in the library could be identified and fault-model based predictive controller is activated. Finally, two kinds of pre-considered high-pressure compressor and high-pressure turbine component-level faults are taken as an example to design the active fault-tolerant controller. Simulation results show that the judgement module owns the ability to sense the fault and gives smooth switching signal to the suitable predictive controller, verifying the effectiveness of the proposed technique.
Influence of plasma-chemical products on process stability in a low-emission gas turbine combustion chamber
Authors: Serbin Serhiy , Kozlovskyi Artem , Burunsuz Kateryna
Published: April 2021

The article describes the stability of gaseous fuel combustion in gas turbine low-emission combustion chambers with the plasma-chemical assistance. The mathematical model of unsteady processes in a low-emission combustion chamber with a plasma-chemical stabilizer that takes into consideration the impact of low-temperature plasma on aerodynamics flow in a combustion chamber and the characteristics of heat release is developed. A methodology of a numerical experiment concerning the stability of gaseous fuel combustion in a combustion chamber with plasma assistance using computational fluid dynamics, which enhances the efficiency of designing and adjustment, is proposed. Practical recommendations for improvement of stability of a gas turbine combustion chamber with partially premixed lean fuel–air mixtures, working on gaseous fuels, are developed. They allow to reduce pressure fluctuations inside the flame tube by 10–35%, to decrease spectral power of static pressure in the flame tube in 1.5–2.0 times, to reduce nitrogen oxide emission up to 33.6 ppm in the exit section while retaining a carbon monoxide emission level, that corresponds modern international ecological standards.
Influence of nozzle exit geometrical parameters on supersonic jet decay
Authors: Mohanta Prasanta Kumar , Sridhar B. T. N. , Mishra R. K.
Published: April 2021

Experiments and simulations were carried on C-D nozzles with four different exit geometry aspect ratios to investigate the impact of supersonic decay characteristics. Rectangular and elliptical exit geometries were considered for the study with various aspect ratios. Numerical simulations and Schlieren image study were studied and found the agreeable logical physics of decay and spread characteristics. The supersonic core decay was found to be of different length for different exit geometry aspect ratio, though the throat to exit area ratio was kept constant to maintain the same exit Mach number. The impact of nozzle exit aspect ratio geometry was responsible to enhance the mixing of primary flow with ambient air, without requiring a secondary method to increase the mixing characteristics. The higher aspect ratio resulted in better mixing when compared to lower aspect ratio exit geometry, which led to reduction in supersonic core length. The behavior of core length reduction gives the identical signature for both under-expanded and over-expanded cases. The results revealed that higher aspect ratio of the exit geometry produced smaller supersonic core length. The aspect ratio of cross section in divergent section of the nozzle was maintained constant from throat to exit to reduce flow losses.
Evaluation of exit pattern factors of an annular aero gas turbine combustor at altitude off-design conditions
Authors: Muduli Saroj Kumar , Mishra R. K. , Mishra Purna Chandra
Published: April 2021

This paper presents the experimental results of an annular combustor. A full scale full annular combustion chamber is tested at ground test stand simulating altitude off-design operating conditions. Traversing thermocouple rakes are used to measure temperatures over the entire annulus at combustor exit. The radial temperature profile is found to be a strong function of operating parameters while the circumferential pattern factor is within the design goal. Increase in reference Mach number at these off-design conditions has caused the redial temperature profiles to deviate and increase from the intended profile. These results will be used for benchmarking the computational model. The computational model will be used for detail study of the temperature non-uniformity over the entire flight envelope and also for modification of combustor liner for performance improvement.
High-Temperature Performance of Next-Generation Silicon Carbide Fibers for CMCs
Authors: Harrison Shay , Schneiter John , Pegna Joseph , Vaaler Erik , Goduguchinta Ramkiran , Williams Kirk
Published: April 2021

Single-fiber (monofilament, not twisted tow) high-temperature creep performance of refractory ceramic compositions is a fundamental material property that must be examined and understood for the successful deployment of ceramic matrix composite material systems in demanding applications. A novel creep testing approach was devised utilizing an innovative approach to fiber sample attachment and used to evaluate the creep behavior of Free Form Fibers’ LP-30SC and Nippon Carbon-based Hi-Nicalon Type S (HNS) silicon carbide fiber products. The testing apparatus, analytical basis for the creep calculations, including the sample gage length, and collected data are presented. Test conditions include a range of peak hold temperatures, from 1,300°C to 1,500°C, gas environments, and hold time patterns at the peak temperature. Clear differences in resistance to creep degradation were evident between the LP-30SC and HNS fibers, as the LP-30SC demonstrated strong resiliency to high temperature exposure while the HNS showed performance degradation consistent with oxidation attack.
Long-term complete remission under TDM1 and local radiotherapy treatment on an inflammatory HER2-positive breast cancer
Authors: Rivilla Miguel Borregón , Barroso Katherin Martínez , Reguera Irene Ramos , Garrido Alba María Ramos , Mazariegos Rubi Manuel Alejandro , Hernández Beatriz Berzal , Palmero Cristina Gómez , Díez de los Ríos Margarita , Cárdenas Juan David , López Muñiz José Ignacio Chacón
Published: April 2021

Premenopausal female patient is diagnosed at the age of 45 for locally advanced inflammatory HER2-positive breast cancer with axillary node involvement. Her disease reveals bad prognostic factors. In spite of radical mastectomy after intensive neoadjuvant treatment based on chemotherapy and trastuzumab-pertuzumab, early skin infiltration recurrence overcomes. She receives local radiotherapy and TDM1 therapy as first advanced disease line. Toxic side effects are not relevant. She achieves four-years-long disease-free survival. Precise treatment selection is challenging but can find out cancer defeat.
The first serological evidence of Anaplasma phagocytophilum in horses in Slovakia
Authors: Drážovská Monika , Vojtek Boris , Mojžišová Jana , Koleničová Simona , Koľvek Filip , Prokeš Marián , Korytár Ľuboš , Csanady Alexander , Ondrejková Anna , Vataščinová Tatiana , Bhide Mangesh Ramesh
Published: April 2021

Anaplasma phagocytophilumis the causative agent of granulocytic anaplasmosis. It affects humans and several wild and domesticated mammals, including horses. The aim of our study was a preliminary survey of the occurrence of these re-emerging pathogens in horses in Slovakia. The sera from 200 animals of different ages and both sexes were tested for the presence ofA. phagocytophilumantibodies by indirect immunofluorescence assay. Subsequently, detection of the16SrRNA gene fragment ofA. phagocytophilumwas attempted by polymerase chain reaction (PCR) in each blood sample. Our results confirmed the presence of specific antibodies in 85 out of 200 individuals (42.5%), but no significant changes were found between the animals of different ages and sexes. However, the PCR analysis did not detect any positive animals. Our data represent one of the highest values of seropositivity toA. phagocytophilumin horses in Central Europe. These results may contribute to a better understanding of the circulation ofA. phagocytophilumin this region, thus indicating a potential risk to other susceptible species.
A pedagógia és a pszichológia együttélési formái a Debreceni Egyetemen
Authors: Brezsnyánszky László
Published: April 2021

Összefoglaló. Az egyetem alapítását követően 1918-ig nem volt önálló
pedagógiai katedra, lélektani tanszék pedig csak 1970-től működik. A
diszciplínák viszonyát a szakma, a politika és a vidéki egyetem lehetőségei
formálták. A változások szakaszra osztva értelmezhetők: a filozófiába és
pedagógiába foglaltságtól (Tankó, Mitrovics, Karácsony), a pszichológia
fokozatos leválásán át (Kelemen) a térnyerésig (Hunyady, Mészáros, Kovács).
Helyi sajátosság: a lélektan a pedagógiai pszichológia révén emancipálódott.
Erre épülhetett a pszichológia szak indítása, az intézet kiteljesedése. A
változásokat kívánjuk nyomon követni, bemutatni a pedagógia és a pszichológia
szervezeti egységeit, fő képviselőit és a viszony jellemzőit az ezredfordulóig.
A tanulmány helyi forrásokra és szakirodalmi munkákra támaszkodik.

Summary. After the foundation of the University, there had been no
independent professorship in Pedagogy until 1918 and the Department of
Psychology started functioning only from 1970. The relationship of these
disciplines was formed by the profession, politics, and the opportunities of the
rural university. Changes can be interpreted by dividing them into periods: from
their inclusion in philosophy and Pedagogy (Tankó, Mitrovics, Karácsony),
through the gradual detachment of psychology (Kelemen) until their headway
(Hunyady, Mészáros, Kovács). A local specialty: Psychology was emancipated by
pedagogical psychology. In other words, the launching of the psychology major
and the establishment of the department were based on pedagogical psychology. We
trace the changes by presenting the organizational units of pedagogy and
psychology, also their main representatives, and the features of their
relationship up until the turn of the Millennium. The study is based on local
resources and works of special literature.
A kiterjesztett valóság alkalmazása a nyelvoktatásban különös tekintettel a rendészeti szaknyelvre
Authors: Barnucz Nóra
Published: April 2021

Összefoglaló. A felsőoktatás egyik legfontosabb feladata, hogy a
munkaerőpiac által megkövetelt kompetenciákra felkészítse a hallgatókat, tehát a
felsőoktatás, a munkaerőpiac, különösen a rendvédelmi szervek által képviselt
speciális munkaerőpiac kongruenciájának kialakítása kiemelt figyelmet érdemel. A
kompetenciák közül a 21. században megjelenő pozíciók ellátásához a digitális
olvasás- és írástudás, valamint a kommunikáció fejlesztése elengedhetetlen. A
kutatási téma célja a hallgatók digitális és verbális kommunikációs szintjének
fejlesztése a szaknyelvi órák keretében különböző nyelvtanulási módszerek és
nyelvtanulási stratégiák alkalmazásával. Tervezett kutatásunkban empirikus
vizsgálatot végzünk a Nemzeti Közszolgálati Egyetem Rendészettudományi Karán
szaknyelvet tanuló nappali tagozatos hallgatókkal.

Summary. The main task of higher education is to prepare students
for the competencies declared by the labour market, thus the development of
congruence between higher education and labour market especially the special
labour market represented by law enforcement deserves special attention. Among
the competencies, digital skills are placed at the forefront, as digital
literacy and communication are essential for 21st-century positions. The aim of
the research topic is to improve students’ digital and verbal communication
levels with the use of different language teaching methods and language learning
strategies in ESP (English for specific purposes) classes. Empirical research
will be carried out with full-time students at the Faculty of Law Enforcement at
the University of Public Service.
ANALISIS DAMPAK SEGREGASI GENDER DI PESANTREN TERHADAP PERILAKU SANTRI
Authors: Jayana Thoriq Aziz
Published: April 2021

Penelitian ini mengkaji tentang pemberlakuan segregasi gender di Pesantren At-Thoriqiyah, khususnya. Dimana hal tersebut disandarkan pada nilai-nilai keislaman agar tidak bercampur antara laki-laki dan perempuan untuk meghindari kemaksiatan. Namun tidak dipungkiri bahwa pemberlakuan segregasi tersebut juga memicu munculnya perilaku-perilaku yang tabu dan bahkan jauh dari nilai kepantasan. Penelitian ini menggunakan pendekatan deksriptif-kualitatif dengan kategori penelitian lapangan (field research). Data dikumpulkan dengan pengamatan langsung, wawancara, dan studi dokumentasi. Hasil penelitian ini menunjukkan munculnya beragam perilaku santri akibat dari segregasi pemondokan, yakni perilaku positif seperti semakin giatnya belajar dan beribadah, juga perilaku negatif seperti candaan di luar batas kewajaran, dorongan untuk berpacaran, dan perilaku homoseksual. Perilaku-perilaku negatif itu terjadi sebab dorongan internal bilogis (libido) pada diri santri yang menyebabkan disorganisasi nilai, baik nilai agama maupun nilai kesopanan, demi melampiaskan hasratnya. Sehingga butuh tinjauan kembali tentang pemberlakuan segregasi di pesantren mengingat banyaknya perilaku negatif yang bisa merusak citra dan nilai-nilai di pesantren.
Instance-Level Update in DL-Lite Ontologies through First-Order Rewriting
Authors: De Giacomo Giuseppe , Oriol Xavier , Rosati Riccardo , Savo Domenico Fabio
Published: April 2021

In this paper we study instance-level update in DL-LiteA , a well-known description logic that influenced the OWL 2 QL standard. Instance-level update regards insertions and deletions in the ABox of an ontology. In particular we focus on formula-based approaches to instance-level update. We show that DL-LiteA , which is well-known for enjoying first-order rewritability of query answering, enjoys a first-order rewritability property also for instance-level update. That is, every update can be reformulated into a set of insertion and deletion instructions computable through a non-recursive Datalog program with negation. Such a program is readily translatable into a first-order query over the ABox considered as a database, and hence into SQL. By exploiting this result, we implement an update component for DL-LiteA-based systems and perform some experiments showing that the approach works in practice.
Effect of smoking on cardiovascular autonomic functions
Authors:   Tutor, Department of Physiology, SVIMS, SPMCW, Tirupati, Andhra Pradesh, India., P.Vani  , Sharan B Singh M  ,   Prof & Head, Department of Physiology, SVIMS, SPMCW, Tirupati, Andhra Pradesh, India.
Published: April 2021

Introduction: Cigarette smoking is a prime risk factor for cardiovascular morbidity and mortality. Chronic smoking results in autonomic dysfunction leading to increased cardiovascular risk in smokers. The present study was planned to study the effect of smoking on the Cardiovascular Autonomic Functions among smokers. Materials and Methods: Fifty male subjects who were in the age group of 25 to 45 years. They were grouped into 25 smokers and 25 non-smokers. The participant subjects were selected among the staff members, residents and the patients from the routine OPD in SVIMS. Prior to study, they were informed about the procedure and the purpose of the study tests and written consents were obtained from them. The Cardiovascular Autonomic Function Tests were assessed by using a POLYGRAPH which was available in the department. Results and Conclusion: After applying the ‘t’-test for the difference between the two sample means, it was observed that there was a highly significant difference between the mean values of the BMI(i.e.p<0.01) and the para-sympathetic function tests among the smokers and the non – smokers(i.e.p<0.00). The Resting Heart Rate had significantly increased and the Deep breathing difference, the postural tachycardial index (Response to standing) and the Valsalva Ratio had significantly decreased in the smokers as compared to those in the non – smokers. After applying the ‘t’-test for the difference between the two sample means, it was observed that there was no significant difference between the mean values of the Postural hypotension test (i.e. p>0.05) and that there was a highly significant difference between the mean values of the Sustained handgrip test in the smokers and the non – smokers (i.e. p<0.00). KEY WORDS: Cardiovascular autonomic function tests, Smoking, Resting heart rate.
Effect of lung boost device on inspiratory muscle strength in abdominal surgery patients
Authors:   M.P.T Student, Department of Cardiorespiratory physiotherapy, Dr A.P.J Abdul Kalam College of physiotherapy, Loni Ahmednagar, Maharashtra, India., Alande Amisha. A. , Vardhan G.D Vishnu ,   Associate Professor, Dr A.P.J Abdul Kalam College of physiotherapy, Loni Ahmednagar, Maharashtra, India.
Published: April 2021

Background: Abdominal surgery involves a surgical repair, resection or reconstruction of organs inside the abdominal cavity. This may include surgery on the stomach, gallbladder, small intestine (colon), liver, pancreas, spleen, esophagus and appendix affected by infection, obstruction, cancerous growth or inflammatory bowel disease. Post Pulmonary Complications (PPCs), are defined as pulmonary anomalies taking place in the postoperative period producing clinically notable, identifiable disease or dysfunction that critically affects the clinical course. As deconditioning is one of the most common and unnecessary causes of morbidity and mortality, the interventions that are implemented should have the potential to increase the strength of the respiratory muscles and accordingly, expand exercise performance and functional capacity as indicated. The aim of the study was to determine the effect of lung boost device on inspiratory muscle strength training in abdominal surgery patients. Material and Methods: Thirty participants between the age of 20 to 70 years that underwent abdominal surgery were selected and received inspiratory muscle training by lung boost device for twice daily 6 times in a week for 2 weeks. Pre and post intervention assessments were done by PIMax and 6MWD. Result: Result of this study showed significant difference in the PIMax and 6MWD when treated with Lung Boost device. Conclusion: The study concluded that use of Lung Boost device causes significant improvement in inspiratory muscle strength and 6MWD in group of abdominal surgery patients and so addition of Lung Boost device in patients with abdominal surgery will increase the strength of inspiratory muscle as well as the functional capacity. KEY WORDS: Abdominal surgery, Lung Boost device, Maximal inspiratory pressure (PIMax), 6Minute Walk Distance (6MWD).
SPOR TESİSLERİNİN YÖNETİM KAPASİTESİNİ BELİRLEMEYE YÖNELİK BİR ÖLÇEK GELİŞTİRME ÇALIŞMASI
Authors: ÇETİN Arif , KARAÇAM Aydın
Published: April 2021

Bu araştırmada, Türkiye’de spor tesislerinin yönetim kapasitesini analiz eden bir ölçeğin geliştirilmesi amaçlanmıştır. Araştırmanın örneklemi, İstanbul’da yerel yönetimler tarafından işletilen spor tesislerinde görev yapan spor yöneticileri arasından uygun ve erişilebilir örneklem yöntemi ile oluşturulmuştur. Bu yöntemle, araştırmaya Spor İstanbul tarafından işletilen 52 spor tesisinde görev yapan 164 spor yöneticisi katılmış olup katılımcıların %26,2’si (n:43) kadın ve %73,8`i (n=121 kişi) erkektir. Açımlayıcı faktör analizi (AFA) sonucunda ölçeğin dört boyutlu ve 35 maddeden oluştuğu tespit edilmiştir. AFA sonucunda toplam açıklanan varyansın % 72.430 olduğu görülmüştür. Ölçek için cronbach alfa iç tutarlık katsayı 0,976 ve KMO değerinin 0,947 olduğu görülmüştür. Spor Tesisi Yönetim Kapasitesi Ölçeği’nin madde toplam korelasyonlarının 0,562 ile 0,917 arasında değişiklik gösterdiği görülmüştür. Ölçeğe uygulanan Doğrulayıcı Faktör Analizi (DFA) sonucunda 2/sd = 2.332, RMSEA= 0,090, GFI= 0,703, NFI= 0,804, CFI= 0,877 olduğu görülmüştür. Çalışmada elde edilen sonuçlar, Spor Tesisi Yönetim Kapasitesi Ölçeği’nin spor tesislerinin yönetim kapasitesini tespit etmede kullanılabilecek geçerli ve güvenilir bir ölçme aracı olduğunu göstermiştir.
MİLLİ ATLETLERDE D VİTAMİNİ DÜZEYLERİ, ANTROPOMETRİK ÖZELLİKLER VE BAZI BİYOKİMYASAL PARAMETRELERİN DEĞERLENDİRİLMESİ
Authors: YİĞİT Demet , BAYRAKTAR Işık , TAŞKIRAN Dilek
Published: April 2021

Bu çalışmanın amacı, atletizm ulusal takımının çeşitli branşlarında yarışan sporcularda plazma 25-hidroksi D [25(OH)D] düzeyleri, antropometrik ve biyokimyasal parametreleri arasında bir ilişki olup olmadığını değerlendirmektir. Çalışmaya 19 kadın (18,63±3,06 yıl) ve 29 erkek (18,90±2,69 yıl) olmak üzere toplam 48 sporcu katılmıştır. Vücut yağ̆ oranının tayini için kaliper yardımıyla deri kıvrım kalınlığı ölçülmüş ve Jackson-Pollock 7 yöntemi ile hesaplanmıştır. Biyokimyasal değerlendirme için plazma 25(OH)D, testosteron, insülin, kortizol, TSH, tiroksin, glukoz, total kolesterol, HDL, LDL ve trigliserid düzeyleri ölçülmüştür. Tüm veriler SPSS18.0. programı ile analiz edilmiş ve p değeri
Convolutional Neural Network Based Advertisement Classification Models for Online English Newspapers
Authors: Et. al. Pooja Jain,
Published: April 2021

Image processing for knowledge management and effective information extraction is the key element for steering towards society 5.0. There has been a substantial research and progress in the area of image recognition and classification in the recent years but at the same time, there is a lack of significant work in the field of advertisement image classification from online English newspapers. This research paper analyses and compares various popular image classification techniques to find out the most suitable technique for advertisement image classification problem. Automatic feature extraction without any prior knowledge of features makes Convolutional Neural Networks (CNN) the most suitable technique for advertisement image classification. This paper further explores and implements three different CNN-based image classification models that can classify advertisement images from online English newspapers into four pre-defined categories including Admission-notices, Job-advertisements, Sales and Promotional advertisements and Tenders. These models are trained and tested on an advertisement image dataset collected from four different online English newspapers over a time frame of 15 months. Fine-tuned ResNet50 Model using ‘Transfer-learning’ is found to be the most suitable model for this advertisement image classification task with results exhibiting around 74% accuracy.  This CNN-model based automated classification of advertisement images will help newspaper readers in performing exhaustive advertisement search in a category of their own interest, saving the time and efforts of sequential manual search across a range of multiple newspapers. Also, the proposed research will help in performing advertisement analysis and studies.
Modified Energy Efficient with ACO Routing Protocol for MANET
Authors: Et. al. Uppalapati Srilakshmi,
Published: April 2021

Due to the specific design of the network upon the requirements of the demands as well as the situation at which the setting up of a physical network is impossible, a significant role is played by mobile ad-hoc network (MANET) in the applications of military. Various critical tasks like robust & dynamic military workstations, devices as well as smaller sub-networks within the battle field are handled by the presented network type controls the infrastructure less communication. A highly demand of the efficient routing protocol’s design is existing which ensures safety as well as reliability to transmit the extremely vulnerable as well as the secret military data within the defense networks. The designing of an energy efficient layer routing protocol within the network on behalf of the military applications is done in this method and the simulation is done with the help of a novel cross layer approach of design for increasing the reliability as well as the lifetime of the network. However, the optimum path selection is not allowed by PDO-AODV technique. Therefore, a novel ACO-DAEE (Ant colony optimization with delay aware energy efficient) to select an optimum path as well as to mitigate the delay time within the network system is proposed. Maintaining the optimum paths within the network while transmitting the data effectively is the major objective. With respect to packet delivery ratio, end to end delay, and throughput, it is indicated by the simulation outputs that the performance of ACO-ADEE is quite good. The efficiency of this technique is verified in the simulation outcomes using NS2 software.