bluuebunny/crossref_metadata_2025 huggingface dataset:
Efektivitas Pemberian Vankomisin Oral Terhadap Kolitis Infektif pada Anak
Authors: Kusumawati Jeshika Febi , Kadim Muzal
Published: July 2021

Latar belakang. Kolitis bermanifestasi sebagai diare kronik dan pada anak perlu diwaspadai karena memiliki komplikasi gangguan tumbuh kembang dan kematian. Sepuluh hingga dua puluh persen kasus diare infeksi akibat perawatan di rumah sakit disebabkan oleh Clostridium difficile. Metronidazol dan vankomisin oral masih menjadi terapi obat lini pertama untuk infeksi Clostridium difficile. Pada pasien diare berat, studi menunjukkan vankomisin oral menjadi pilihan utama dibandingkan metronidazole.Tujuan. Mengetahui efektifitas pemberian vankomisin oral terhadap metronidazol oral dalam menyembuhkan kolitis infektif kronik pada anak.Metode. Pencarian literatur melalui Pubmed dan Cochrane pada bulan Juli 2019 dengan kata kunci “children OR pediatric” AND “infective colitis OR Clostridium difficile” AND “oral vancomycin” AND “ oral metronidazole”.Hasil. Penelusuran artikel pada makalah ini menemukan dua artikel yang relevan terhadap pertanyaan klinis. Igarashi dkk. merupakan meta analisis terhadap lima uji klinis acak dengan total 1101 pasien dan dipublikasikan pada tahun 2018. Artikel yang kedua adalah studi pilot prospektif observatif dari Antoon dkk pada 8 subyek anak berusia 8-17 tahun pada tahun 2016.Kesimpulan. Vankomisin oral disarankan untuk digunakan dalam kolitis infektif berat. Untuk kasus kolitis infektif yang ringan atau sedang, data menunjukkan hasil yang seimbang untuk vankomisin dan metronidazol. Berdasarkan uji observasional, vankomisin oral tidak diabsorbsi dalam darah pada anak.
Symbolic images in the poem by Semyon Bobrov "The Ancient Night of the Universe, or the Wandering Blind"
Authors: Bulgakova Anna
Published: July 2021

The article is devoted to the study of symbolic images in the philosophical and esoteric poem by Semen Bobrov "The Ancient Night of the Universe, or the Wandering Blind". The poet's interest in traditional symbolism is due to both the transitional situation that characterized the end of the 18th century and the influence of Masonic ideas on the poet. S. Bobrov's dialectical thinking manifested itself in the transformation of the traditional dichotomous structure of the world. Endowed with opposite semantics, the concepts underlying the symbols grouped around the archetypal images of Chaos and Cosmos reveal a deep relationship in the poem. For this, the poet combines the dyads of oppositions, forms a system of reflections, introduces semantic intermediaries, endows images with ambivalent meanings and allows the inversion of the dyads. Light and ray, acting as the main symbols in the poem, pull together many images (wheel, sun, moon, lamp, night, eye, etc.) around themselves and embody the idea of movement, which is the meaning and formative in the poem.
The Role of Value-Semantic Oppositions in Revealing the Deep Literary and Psychological Characteristics of the Narrator’s Image in “Poor Liza” by N.M. Karamzin
Authors: Krasnova Olga
Published: July 2021

Value-semantic oppositions in the novel by N.M. Karamzin, seen as meaningful text dominants in situations of "existential fullness", are discussed in the article from the point of view of an interdisciplinary approach of literary criticism, text theory, psychology and linguistics. The article describes the process of literary and psychological meaning generation, coupled with the narrator’s inherent properties, as well as implicit literary and psychological textual relationships with inherent properties, it also singles out the contextual ways of these characteristics, reflecting motives, attitudes, generalized worldview judgments (generalizations). The author shows the dialog nature of the narrator’s literary and psychological attitude to the realities denoted by various parts of the opposition in the situation of “existential fullness”. The role of lexical markers corresponding to the depicted integral emotional state of the narrator in the privision of active reader's attention and attracting him to the deep literary and psychological characteristics is revealed.
Reconstrucción de la papila interdental con ácido hialurónico. Artículo de Revisión Corto
Authors: Alvarado Cordero Jacinto José , Luna Pesántez María Cristina , Cáceres Montalván Eduardo Sebastián
Published: July 2021

One of the most frequent cosmetic dental problems is the presence of black triangles due to the loss of the interdental papilla. There are several surgical and non-surgical treatment options to correct this anomaly, among the most innovative and less invasive we found the use of an injectable gel of hyaluronic acid for the reconstruction of the interdental papilla. The objective of the study was to carry out a bibliographic compilation on the effectiveness of hyaluronic acid as a treatment for the reconstruction of the interdental papilla
Profile of the CRO in Colombia
Authors: Nuñez Maria Antonia , Villanueva Eduart
Published: July 2021

Este artículo analizó el perfil que requiere un gerente de riesgos (CRO, por sus siglas en inglés) en grandes empresas de Colombia a partir del conocimiento de los rasgos, habilidades, aptitudes y conocimientos que son necesarios para lograr un adecuado desempeño, de modo que contribuya a la consecución de objetivos. El estudio se desarrolla bajo una metodología cualitativa de alcance descriptivo. Se llevaron a cabo entrevistas semiestructuradas a siete CRO de grandes empresas colombianas de diversos sectores y se entrevistó a dos expertos. En los resultados encontrados, se puede evidenciar la importancia del CRO y el desarrollo de su perfil tanto en aspectos técnicos como en las habilidades blandas que requieren, para que puedan aportarle valor a la empresa con su experticia y una visión prospectiva sobre las situaciones de riesgos a las cuales pueden verse expuestos. El artículo aporta al conocimiento existente sobre el CRO que requiere de mayor investigación académica.
Prerequisite Evaluation of Anaerobic Settings for Gut Microbiome Functional Studies
Authors: Hatta Muhammad Nur `Adam , Mohamad Hanif Ezanee Azlina , Chin Siok-Fong , Neoh Hui-min
Published: July 2021

Colon cancer-associated gut bacteria were mostly identified via next-generation sequencing in gut microbiome profiling studies. Anaerobic culture systems can be used to culture colon cells with these gut bacteria to further confirm the tumorigenic properties of these bacteria. Nevertheless, it is unclear how colon cells will grow in an anaerobic environment, as most cells are cultured aerobically. Therefore, we investigated the survival and viability of HT-29, a colon cancer cell line in an anaerobic culture system, and compared it to the usual culture condition in an aerobic setup. Interestingly, we found that HT-29 was able to grow in the anaerobic setup. Its viability was similar for both culture conditions, with only a slower growth rate observed in the anaerobic setup. Furthermore, gene expression studies showed that the cells were not under severe anaerobic stress even when exposed to the oxygen-deprived environment.This study provided results on some baseline parameters of an anaerobic colon cell culture system, and will be useful for journal readers who wish to investigate functional properties of anaerobic bacteria.
Degree of coronary occlusions links to the patient clinical outcome: four cases of double culprits acute ST-segment elevation myocardial infarction
Authors: Uddin Ilham , Wardhani Anindia , Cahyadi Misbah Hari , Puspitasari Desy Ayu , Ardhianto Pipin , Bahrudin Udin , Herry Yan , Rifqi Sodiqur
Published: July 2021

Background: Double coronary culprit lesions in ST-segment elevation myocardial infarction (STEMI) is uncommon. Despite successful primary percutaneous coronary intervention (PPCI) in all culprit lesions, the clinical outcome remains unfavorable and the possible factors for the outcome are not fully understood.Cases Presentation: We reported four cases of double culprit lesions STEMI underwent PPCI. Patient A, a 62 y.o. male with extensive anterior-inferior STEMI, had total occlusion (TO) at both proximal left anterior descending (LAD) and mid right coronary artery (RCA). Patient B, a 42 y.o. male with extensive anterior-inferior STEMI, had subtotal occlusion (STO) at proximal RCA and TO at proximal LAD. Both of them had RBBB ECG pattern. Patient C, a 67 y.o. male with inferior STEMI had 90% thrombus occlusion at proximal–mid LAD and TO at proximal RCA. Patient D, a 65 y.o. male with anteroseptal STEMI, had STO at proximal LAD and 80% thrombus occlusion at mid left circumflex. The cardiomyocyte infarction biomarkers increased in all patients. Although all of them underwent successful PPCI in all of culprit lesions, they suffered from acute heart failure and two of them experienced recurrent ventricular arrhythmia episodes. One of them (patient A) died two days post PPCI. He was only patient who suffering from total occlusion in LAD and RCA with TIMI thrombus 5 and experienced a total atrioventricular block post-PPCI.Conclusion: STEMI with coronary double culprits have severe clinical outcome, regardless of the successful PCI. The degree of coronary occlusions might be linked to the patient clinical outcome.
The Evaluation of Parental Acceptance Towards Children with Sex Chromosomal Disorders of Sex Development Using A Mixed-Method
Authors: Fitrianingrum Iit , Ediati Annastasia , Winarni Tri Indah , Faradz Sultana MH
Published: July 2021

Background: Sex chromosomal Disorder of sex development (DSD) is an atypical abnormality of external genitalia which is mismatched with its sex chromosome traits. The condition of children with DSD affects the dynamics in the family. Parents’ reactions after discovering this health problem vary greatly, such as being in a state of shock, confusion, or self-blame. However, parents’ acceptance is extremely important for better quality of caring, to the healthy social and emotional child development, and to make the best decisions regarding gender assignment.Objective: To describe the acceptance process of parents that have children with sex chromosomes mosaicism DSD.Methods: This study used a mixed-method with a sequential explanatory approach, which was preceded by quantitative data collection followed by qualitative. The total respondents consisted of 14 mothers and 12 fathers of 14 sex chromosome mosaicism DSD patients with XX/XY, X/XY, XYY or XXY variants. Quantitative data were collected using the Indonesian version of the Parental Acceptance-Rejection Questionnaire (PARQ), and interviews were conducted to determine the acceptance process.Results: Most acceptance cases were based on the surgical stage completion in which a higher number of mothers (71.43%) than fathers (50%).Conclusion: It is uneasy for parents to accept children with sex chromosome mosaicisms DSD, hence the fathers struggle more than mothers in accepting those affected. To the best of our knowledge this is the first study in Indonesia to help parent understand and accept their child condition.
IPB University's Policy of Biodiversity’s Innovation for Eco-Edutourism
Authors: Satria Arif , Hidayat Aceng , Abdul Haris Abdul Haris
Published: July 2021

IPB University has declared as a Biodiversity Campus since 2011. This declaration was carried out considering the high biodiversity at the IPB University Campus. One of the causes of the high campus biodiversity is the uniqueness of the campus landscape and the maintained proportion between the built and open-green areas. The existence of lakes, forests, arboretums, plantations, and three rivers that cross the campus area has contributed to the high diversity of habitats and consequently to the biodiversity. At least 22 species of mammals, 99 species of birds, 12 species of amphibians, 38 species of reptiles, 128 species of butterflies, 173 species of woody-plants, 40 species of bamboos and 127 species of medicinal plats have been recorded inhabiting the 257 ha of the campus area. The biodiversity has significant role as objects for research of the students, lecturers, researchers as well as for tourism such as for bird watching, picture hunting, outbond and other recreational activities. Therefore the campus functions for education and for tourism, thus ecoedutourism for academic community as well as community around the campus. To maintain the biodiversity, IPB University issued several policy innovations. The first policy innovation is monitoring of population and distribution of biodiversity on a regular basis. Second, habitat management for biodiversity. Third, on-site and offsite socialization to campus and offcampus communities. Fourth, conserving the habitats of the flora and fauna. Fifth, rare tree planting. Sixth, the movement to plant fruit trees by each faculty. Seventh, conservation of biopharmaceutical medicinal plants. Eighth, building a garden for food sovereignty. Ninth, conducting research on campus biodiversity. All of these policies involve the academic community, experts, alumni and the community around the campus.
Green University Garden Towards Region Sustainability
Authors: Fadeeva Marina , Cherkasova Oksana
Published: July 2021

Growing actions on putting into practice the policy for improving sustainable development gives universities great variety of opportunities on implementation of different ‘green’ technologies in their campuses. Campus greening is the first step towards sustainability. The purpose of this article is to present existing approaches on the categories of sustainable campus initiatives, their significance for complete region development and the state of the environment. On the example of the inner garden of Volgograd State University, the authors describe the importance of greening the external campus sites for minimization of the negative environmental and health affects for students and faculty staff. The green initiative reflects the institution’s function as center of technological and social regional development. The green garden can reduce stress and also provide an esthetic sense by involving attractive surroundings. The impact of climatic zone on emerging of appropriate management and maintenance systems, meaningful comparison with the past landscape solutions are also reviewed in the present article. By implementing green technologies, the university shows its prudence and readiness to behave responsibly, sensibly and maturely in response to sustainability issues of the present and the future.
Filmowość literackiego cyberpunku na przykładzie powieści Neuromancer Williama Gibsona
Authors: Prusinowski Piotr
Published: July 2021

Neuromancer (1984) Williama Gibsona uważany jest za pierwszą powieść reprezentującą podgatunek literatury fantastycznonaukowej zwany cyberpunkiem. Charakterystyczna dla tego nurtu wizja świata niedalekiej przyszłości, zmodernizowanego, a zarazem zdegradowanego przez technologię, znalazła odbicie w licznych filmach. Warto jednak pamiętać również o tym, jak istotną rolę samo kino odegrało w kształtowaniu się estetyki cyberpunkowej prozy. Przykład Neuromancera pokazuje, że ten wpływ nie ograniczał się do inspiracji wątkami fabularnymi z takich obrazów jak Ucieczka z Nowego Jorku (Escape from New York, 1981) Johna Carpentera, lecz przede wszystkim dawał o sobie znać w specyficznie „filmowej” wizualności języka literackiego, którym posługiwał się Gibson.
Dotykanie minionego. Fortepian Jane Campion jako przykład adaptacji auratycznej
Authors: Jauksz Marcin
Published: July 2021

Artykuł jest próbą zdefiniowania zjawiska w światowym kinie współczesnym, które wykorzystując nowe sposoby komunikacji w obrębie sztuk wizualnych i ich haptyczności, stara się rekreować nastroje i wrażliwości konotowane z kulturą minionych czasów. Fortepian Jane Campion, jako świadectwo zaangażowanej lektury przede wszystkim poezji Emily Dickinson, ale też Wichrowych Wzgórz Emily Brontë, staje się tu przykładem fabuły z jednej strony nasyconej perspektywami, motywami i sytuacjami zaczerpniętymi z tych utworów, z drugiej wykorzystuje stylistyczną multisensoryczność kina, by w przedstawionych bohaterach i przedmiotach ich otaczających odtwarzać dynamikę relacji i nastroje znane z przekazów o kulturze połowy XIX wieku. Dzięki temu staje się auraptacją (adaptacją auratyczną; ang. auraptation – auratic adaptation), adaptacją aury wyczytanej spomiędzy literackich świadectw epoki, przeniesieniem w dzisiejsze czasy i właściwe im media niepowstałej w wieku XIX opowieści.
Deamidation and glycation of a Bacillus licheniformis α-amylase during industrial fermentation can improve detergent wash performance
Authors: Pontoppidan Connie , Kaasgaard Svend G. , Sønksen Carsten P. , Andersen Carsten , Svensson Birte
Published: July 2021

The industrial thermostable Bacillus licheniformis α-amylase (BLA) has wide applications, including in household detergents, and efforts to improve its performance are continuously ongoing. BLA during the industrial production is deamidated and glycated resulting in multiple forms with different isoelectric points. Forty modified positions were identified by tandem mass spectrometric peptide mapping of BLA forms separated by isoelectric focusing. These modified 12 asparagine, 9 glutamine, 8 arginine and 11 lysine residues are mostly situated on the enzyme surface and several belong to regions involved in stability, activity and carbohydrate binding. Eight residues presumed to interact with starch at the active site and surface binding sites (SBSs) were subjected to mutational analysis. Five mutants mimicking deamidation (N→D, Q→E) at the substrate binding cleft showed moderate to no effect on thermostability and k
cat and K
M for maltoheptaose and amylose. Notably, the mutations improved laundry wash efficiency in detergents at pH 8.5 and 10.0. Replacing three reducing sugar reactive side chains (K→M, R→L) at a distant substrate binding region and two SBSs enhanced wash performance especially in liquid detergent at pH 8.5, slightly improved enzymatic activity and maintained thermostability. Wash performance was most improved (5-fold) for the N265D mutant near substrate binding subsite +3.
Decomposing Employment Trends of Disabled Workers
Authors: Koning Pierre , Vethaak Heike
Published: July 2021

This paper estimates Age–Period–Cohort models on employment rates of Dutch Disability Insurance (DI) applicants. We find that the substantial decrease in employment between 1999 and 2013 is explained by year-of-application cohort effects and that period effects are negligible. In turn, application cohort effects partly stem from increasing shares of applicants without permanent contracts. Changes in application cohort effects are largely confined to the years following two DI reforms that increased self-screening among workers. We next analyze changes in employment rates of awarded and rejected applicants and follow a Difference-in-Differences approach. Assuming common compositional cohort effects, we infer negligible effects of changes in benefit conditions.
IUPAC first Virtual World Chemistry Congress and General Assembly
Authors: Burford Neil
Published: July 2021

On behalf of the Organizing Committee for IUPAC|CCCE 2021, I am delighted to invite you to the 51st IUPAC General Assembly (GA) and 48th World Chemistry Congress (WCC), in conjunction with the 104th Canadian Chemistry Conference and Exhibition (CCCE). The IUPAC|CCCE 2021 events will be hosted by the Canadian Society for Chemistry (CSC), the Canadian National Committee for IUPAC (CNC-IUPAC) and the National Research Council Canada (NRC). Canada has previously hosted the IUPAC GA & WCC in Vancouver (1981) and Ottawa (2003). The original plans for IUPAC|CCCE 2021 were for the events to take place in Montréal, QC, Canada, 13-20 August 2021. Unfortunately, as travel to Montréal are impeded by the global pandemic, all events associated with IUPAC|CCCE 2021 will occur virtually. As chemical sciences professionals, we know conferences are a key venue for professional development, networking, and scientific advancement, and we will work to ensure that these principles stand true for the virtual event as well. While not a replacement for in-person events, this new endeavour will synthesize the best of our in-person events, with the convenience and accessibility of a virtual event. Beyond that, a virtual experience provides unique opportunities to engage a global audience, reach more young professionals, reduce our environmental impact, and stay safe.
Strategies for Success as an Industrial Chemist
Authors: Ribes Carolyn
Published: July 2021

Chemists find careers in the chemical industry very rewarding. The focus is on applied chemistry and in delivering solutions that meet customer needs, whether the customers are other industrial companies or individual consumers. Chemistry provides solutions to the global challenges facing our society, including the need for clean water, nutritious food, improved healthcare and wellness, affordable housing, and sustainable infrastructure. Within industry, chemists serve in a wide variety of roles. The largest fraction may be in research and development (R&D), although opportunities in manufacturing, technical service and development, supply chain, marketing, intellectual property protection, sales and commercial functions, and many other options are also open to chemists who want to apply their skills [1]. I was drawn to a career in industry because I’m results oriented and I wanted my work to be applied immediately and have an impact.
COMEST: Ethical Advice across Scientific and Geographic Borders
Authors: Sydnes Leiv K.
Published: July 2021

COMEST, an acronym for the French name of the World Commission on the Ethics of Scientific Knowledge and Technology [1], is an advisory body within United Nations Educational, Scientific and Cultural Organization (UNESCO) and a forum of reflection, “mandated to formulate ethical principles that could provide decision-makers with criteria that extend beyond purely economic considerations.” [2] Over the years, the Commission has addressed ethical issues in many areas where science and technology have an impact on people, nature, and society. The deliberations result in reports, which are put forward to the biannual General Conference of UNESCO for discussion and adoption. The outcome has often been ethical recommendations and guidelines to consider and hopefully abide to so that science can interact with society in a responsible way and without adverse consequences.
Topological Formulae for the Zeroth Cohomology of Line Bundles on del Pezzo and Hirzebruch Surfaces
Authors: Brodie Callum R. , Constantin Andrei , Deen Rehan , Lukas Andre
Published: July 2021

We show that the zeroth cohomology of effective line bundles on del Pezzo and Hirzebruch surfaces can always be computed in terms of a topological index.
A dossier on COVID-19 chronicle
Authors: Rufaida  , Mahmood Tarique , Kedwai Ismail , Ahsan Farogh , Shamim Arshiya , Shariq Mohammad , Parveen Saba
Published: July 2021

The dissemination of the 2019 novel coronavirus (2019-nCoV) is presenting the planet with a new health emergency response or threat to health. The virus emerged in bats and was disseminated to humans in December 2019 via still unknown intermediate species in Wuhan, China. It is disseminated by inhalation or breaks out with infected droplets and the incubation period is between 2 and 14 days. The symptoms usually include high body temperature, cough, sore throat, dyspnea, low energy or tiredness, and weakness. The condition is moderate in most people; but in the elderly and those with comorbidities, it advances to pneumonia, acute respiratory distress syndrome (ARDS), and multiple organ failure. Popular research work includes normal/low WBC with upraised C-reactive protein (CRP). Treatment is generally supportive and requires home seclusion of suspected persons and rigorous infection control methods at hospitals. The Covid-19 has lower fatality than SARS and MERS. Among the proposed therapeutic regimen, hydroxychloroquine, chloroquine, remdisevir, azithromycin, toclizumab, and cromostat mesylate have shown promising results, and the limited benefit was seen with lopinavir–ritonavir treatment in hospitalized adult patients with severe COVID-19. Early development of the SARS-CoV-2 vaccine started based on the full-length genome analysis of severe acute respiratory syndrome coronavirus. Several subunit vaccines, peptides, nucleic acids, plant-derived, and recombinant vaccines are under pipeline. Research work, development of new medicines and vaccines, and efforts to reduce disease morbidity and mortality must be encouraged to improve our position in the fight against this disease and to protect human life.
In vitro anticoagulant activity of selected medicinal plants: potential interactions with warfarin and development of new anticoagulants
Authors: Leite Paula Mendonça , Freitas Aline , Amorim Juliana , Figueiredo Rita Carolina Duarte , Bertolucci Suzan , Faraco André , Martins Maria , Carvalho Maria G. , Castilho Rachel
Published: July 2021

Objectives

Warfarin is the most widely used anticoagulant in the world, but it has several limitations including its narrow therapeutic range, need for dose adjustment and high potential for interactions. The simultaneous use of other drugs or even medicinal plants and certain foods could interfere with its therapeutic activity. In this context, this study aims to investigate the in vitro anticoagulant potential and phytochemical constitution of 17 plants selected from a previous clinical cross-sectional study (2014), that investigated the habits of plant utilization among patients taking warfarin.

Methods

Ethanol extracts and essential oils were evaluated, in vitro, as to their effect in the prothrombin time (PT) and activated partial thromboplastin time (aPTT) tests. Four species that presented aPTT >50 s were selected for phytochemical evaluation.

Results

Thirteen of the 17 plants selected demonstrated a significant anticoagulant effect in at least one of the evaluated parameters. Citrus sinensis (PT=14.75 and aPTT=53.15), Mentha crispa (aPTT=51.25), Mikania laevigata (PT=14.90 and aPTT=52.10), and Nasturtium officinale (aPTT=50.55) showed greater anticoagulant potential compared to normal plasma pool (PT=12.25 and aPTT=37.73). Chemical profiles of these four species were obtained, and certain compounds were identified: rosmarinic acid from M. crispa and isoorientin from N. officinale.

Conclusions

Thus, the results of this study could be a useful indicator for clinical practice towards the possibility of interaction between these plants and anticoagulants, although further clinical research is needed taking into consideration the limitations of in vitro studies. These findings also suggest that further research into the action of these plants could be of real clinical value in identifying potential alternative anticoagulant therapies.
Lab on optical fiber: surface nano-functionalization for real-time monitoring of VOC adsorption/desorption in metal-organic frameworks
Authors: Wu Jieyun , Tang Chunlan , Zhang Wanying , Ma Xiaoxia , Qu Shiwei , Chen Kaixin , Hao Ting , Chiang Kin Seng
Published: July 2021

Metal-organic framework (MOF) nanomaterials are emerging porous coordinative polymers with large surface area and high porosity. Their application scenarios highly depend on adsorption/desorption dynamics of guest molecules in the framework. For representative ZIF-8 with framework flexibility, the study of molecule transportation in the pore channels of ZIF-8 will address the ambiguity of unclear application scenarios. In this study, the integration of lab-on-fiber technology and nanotechnology are demonstrated for real-time monitoring of adsorption/desorption dynamics of heterocyclic volatile compounds (VOCs) with kinetic diameters larger than the window aperture of ZIF-8. The in-line fiber interferometer with cascaded long-period gratings is used to monitor the real-time refractive index change of VOC adsorption/desorption. The structure-effect relationship between guest VOCs and framework flexibility is analyzed. It shows that the adsorption dynamics is highly related to the molecular geometry and kinetic diameter. The framework flexibility results in the trapping of guest VOCs toluene, pyridine, and tetrahydrofuran in the frameworks. The methanol adsorption/desorption is an effective strategy for the fast desorption of trapped residual VOCs in the framework. Finally, we conceptually demonstrated the real-time monitoring of trace toluene enrichment using ZIF-8 for indoor air purification. This study paves the way for the in-depth understanding of framework flexibility for MOF’s application.
Effect of Tuck and Miss Stitch on the Geometrical Properties of Regenerated Cellulose Plain and Derivative Knit Structures
Authors: Divya R. , Prakash C. , Sampath Kumar S. Kubera , Rathinamoorthy R. , Kumar K. V. , Rajwin A. Jebastin
Published: July 2021

This study aimed to analyze the effect of tuck and miss stitch structures of regenerated cellulose fabrics like viscose, modal, Tencel, and bamboo. The fabrics were developed with the same stitch length and tightness factor and analyzed for their geometrical properties after dry and wet relaxation. The study results revealed that wet relaxation treatment showed more significant changes in the geometrical constant values (K) than the dry relaxation process. The highest wale density change was noted with cross miss stitch fabric and a maximum course density change noted for cross tuck samples after dry and wet relaxation. The differences in wale and course density were noted as statistically insignificant for the aforementioned structure after dry and wet relaxation (p > 0.05). However, in the case of stitch density, there is a statistical significance noted for the tested samples (p < 0.05). The maximum changes were noted in plain fabric followed by twill structure. The loop shape factor (Kr) value suggests higher distortion in the cross tuck fabric and after wet relaxation over dry relaxed samples followed by plain, twill, and miss stitch structures, and we also noted the relaxation process did not alter the loop shape factor (Kr) significantly between the dry and wet process (p > 0.05).
Methodology of designing specialized medical information registries
Authors: Fedonnikov Aleksander , Kolesnikova Anna , Rozhkova Yuliya , Kirillova Irina , Bessonov Leonid , Ulyanov Vladimir , Kossovich Leonid
Published: July 2021

The objective. Developing information exchange methodology by means of specialized registries among the core healthcare partakers in the course of provisioning medical assistance to traumatology and orthopedic patients. Materials and Methods. We conducted the analysis and systematization of functionality for 31 registers of traumatology- and orthopedics-related medical information from the databases of the Federal Institute of Industrial Property, European Patent Office and developers’ websites. The search depth has been set at 1979 and defined by the date of the earliest discovered information source. Results. The analysis of specialized registries revealed that majority of those (70.9%) were mono-nosologic, hence containing information about the diagnosis and treatment procedures provided at the level of a specific medical institution. We developed the methodology for evaluating the functionality of specialized medical information registries, containing the data on used medical devices, medications, medical technologies, rehabilitation programs, and assessment of medical treatment effectiveness. Such methodology was designed to operate on data from the information systems of major healthcare partakers. Conclusion. The proposed information exchange methodology defined the necessity of integrated, target-oriented registry development. Its implementation would allow increasing the quality of management decisions proposed by healthcare participants.
Optimizing the process of developing human blood vessel models
Authors: Dol Alexander , Ivanov Dmitry , Fomkina Olga
Published: July 2021

Objective: to optimize the process of blood vessel biomechanical modeling via developing models of cerebral arterial circle.
Materials and methods. Biomechanical modeling requires development of a patient-oriented three-dimensional (3D) solid-state geometric model of the object under study. This task can be resolved by computed tomography (CT) or magnetic resonance imaging (MRI). We developed the program that implements the construction of blood vessel contours from separate slices of MRI in a semi-automatic mode. These contours are exported as saved curves in a specific format to SolidWorks, where they are used to create 3D models of blood vessels. The models obtained this way take into account individual characteristics of the vascular system structure of a particular patient, and can be used in the process of biomechanical modeling.
Results. The results of the program implementation of the recursive frontal growth method for processing 2D slices of tomograms are presented.
Conclusion. The developed software allows semi-automatic loading of DICOM images and obtaining flat cross-sections (MRI slices) of vessels on their basis, as well as transferring them for further processing into computer-aided design systems.
Traumatology institutions in the early years of the soviet state: a gap in the history of Russian traumatology and orthopedics
Authors: Grishin Sergei , Ulyanov Vladimir , Fedonnikov Aleksander , Norkin Igor
Published: July 2021

Background. The formation and development of industrial model for social processes and systems in the early twentieth century brought to life a novel form of organizing scientific activity via establishing research institutions.
Objective. This study aimed to investigate the gaps in the history of traumatology institutions in the early years of the Soviet State.
Materials and methods. We carried out a comprehensive analysis to retrieve the data from both State and institutional archives, as well as from the literature sources. The narrative analysis was chosen as the method of data interpretation. Most archive documents are made available to the scientific community for the first time. Our study covered the period of time from 1917 to 1930. Over 500 sources were analyzed.
Results. We established that the first five traumatology institutions were founded in the following sequence: Saratov Traumatology Institute in 1919, Rostov Traumatology Institute in 1920; Astrakhan, Moscow Oblast, and Voronezh Traumatology Institutes in 1921. The concept of research institution was mainly designed to achieve the systematic augmentation of scientific knowledge and form a new employee type called a professional scientist.
Conclusion. Discovering the history of establishing first traumatology institutions that provided healthcare services and conducted independent scientific studies led us to defining a new, previously unexplored institutionalization stage of Russian traumatology and orthopedics. In the early years of the Soviet State, research institutions facilitated the development and implementation of efficient medical technologies into healthcare practice.
Bonding performance of plywood with pig blood adhesives prepared by a novel method
Authors: Du Keke , Yong Cheng , Guan Mingjie , Zhang Fan
Published: July 2021

Renewable and eco-friendly pig blood adhesives (PBAs) were obtained by modifying PBAs with a mild alkaline solution and glutaraldehyde and exposing them to an ultrasound treatment. The PBAs were subjected to thermogravimetric (TG) analysis and Fourier transform infrared (FTIR) spectroscopy, and the bonding strength and bonding interface of plywood were analyzed to evaluate bonding performance. The results showed that the alkaline solution unfolded the structure of blood proteins, and the glutaraldehyde crosslinked the blood protein. In addition, the ultrasound greatly increased protein expansion under weak alkaline conditions. The thermal stability of the PBAs exposed to ultrasound treatment under weak alkaline conditions was improved, but the crosslinking agent was not used, and the permeability, which was analyzed by a fluorescence microscope, improved. Further, the average and effective penetration depths on the bonding interface increased 53% and 55%, respectively. The bonding strength of plywood prepared with modified PBAs was greatly improved and compliant with relevant requirements.
Dielectric properties of natural Borneo woods: Keranji, Kayu Malam, and Kumpang
Authors: Jayamani Elammaran , Rahman Md Rezaur , Hamdan Sinin , Kyari Muhammad Idris , Bin Bakri Muhammad Khusairy , Sanaullah Khairuddin , Khan Afrasyab
Published: July 2021

The dielectric behavior and properties of three types of Sarawak woods, under various conditions (untreated, alkaline treated, potassium carbonate treated, and heat treated), were investigated and discussed. The dielectric constant, loss, and dissipation factor tests were conducted via a dielectric impedance analyzer. The results revealed that the dielectric properties decreased in relation to an increase in frequency. With considerations to the treatment method, the highest dielectric constant values for the untreated samples were found in Kumpang wood, the highest dielectric constant values for the heat-treated samples and potassium carbonate treated samples were found in Keranji wood, and the highest dielectric constant values for sodium hydroxide treated samples were found in Kayu Malam wood. Therefore, it was evident that the physical properties, e.g., internal structure, density, moisture, temperature, etc., could affect the dielectric behavior and properties of the wood materials.
A study of the effect of acetylation on hemp fibres with vinyl acetate
Authors: Özmen Nilgül
Published: July 2021

Chemical modifications of hemp fibers were performed with acetic anhydride (AA) and vinyl acetate (VA) in the presence of pyridine or potassium carbonate as catalysts. Hemp fibers (Cannabis sativa) were successfully acetylated by VA in the presence of potassium carbonate (15% WPG), but no weight gain was obtained when pyridine was used as catalyst. Hemp fibers were also modified with acetic anhydride (AA) in the presence of potassium carbonate and pyridine as catalyst (14% and 16% WPG, respectively) under identical conditions, and the results were compared with those obtained using the VA technique. AA-modified, VA-modified, and control hemp fibers were characterized by Infrared (FTIR), 13C CP MAS NMR and thermo gravimetric analysis (TGA).
Development of a simple HPLC procedure for the determination of prochloraz residues in mushrooms
Authors: Csutoras Csaba , Misz Andras , Nagy-Koteles Csaba , Bakos-Barczi Nora , Racz Laszlo
Published: July 2021

A simple HPLC-UV procedure is described in our paper which is suitable for the rapid and cost-efficient determination of prochloraz in mushrooms. Prochloraz is the only fungicide in EU which use is allowed in mushroom production. The aim of our work was the development of a simple method that is suitable for the control of this pesticide in everyday analyses during mushroom production. The procedure involves a simple sample preparation method based on solid-liquid extraction (modified QuEChERS extraction method EN 15662) followed by an HPLC-UV determination (recovery: 97–99%; limit of detection LOD: 0.01 mg/kg; limit of quantification LOQ: 0.05 mg/kg).
Social-networks-related stimuli interferes decision making under ambiguity: Interactions with cue-induced craving and problematic social-networks use
Authors: Wegmann Elisa , Müller Silke M. , Trotzke Patrick , Brand Matthias
Published: July 2021

Background and aims

Social-networks-use disorder is discussed as a potential further type of disorders due to addictive behaviors. Theoretical models assume cue-induced craving and disadvantageous decision making to be relevant mechanisms. This study investigates if the presentation of social-networks-related cues interferes with decision making under ambiguity.

Methods

Craving was induced with a cue-reactivity paradigm and assessed with a visual analogue scale. Participants (N = 146) played a modified Iowa Gambling Task with social-networks-related cues and neutral cues presented on the advantageous and disadvantageous decks respectively, or vice versa. Symptoms of social-networks-use disorder were measured with a modified version of the short Internet Addiction Test.

Results

Overall, participants chose options with neutral cues more often than those with social-networks-related cues, even if it was disadvantageous. There was a significant interaction between decision-making performance and Iowa Gambling Task condition in predicting symptom severity. The results indicate that choosing decks with social-networks-related cues even if it was disadvantageous is associated with higher tendencies towards a social-networks-use disorder. The interaction with cue-induced craving did not explain further variance.

Discussion and Conclusions

The results highlight the relevance of cue reactivity, decision making, and their interaction as potential mechanisms explaining tendencies towards a social-networks-use disorder. Decision making was influenced by affective responses, which could result in a higher risk of a potential addictive behavior. This is consistent with the findings from addiction research and with theoretical approaches assuming an imbalance between affective and cognitive processes in addictive behaviors.
Transient expression of recombinant S1 protein of Porcine Epidemic Diarrhea Virus in Nicotiana benthamiana
Authors: Thuong Ho Thi , Ngoc Le Thu , Giang Nguyen Thu , Vy Trinh Thai , Hoang Phan Trong , Ngoc Pham Bich , Trang Vu Huyen , Ha Chu Hoang
Published: July 2021

Porcine Epidemic Diarrhea (PED) is an infectious disease with high mortality especially in suckling piglets. Among the structural proteins of Porcine Epidemic Diarrhea Virus (PEDV), the S protein (including sub-domain S1 and S2), is a homotrimer protein that plays an important role in attaching the viruses to the cell receptors. In particular, the S1 protein is considered as an important sub-component in the development of effective vaccines against PEDV. In this study, for the purpose of expressing S1 in the original form of trimmer and oligomer of trimer based on S-tag and S-protein interactions, the DNA encoding for S1 protein was fused with GCN4pII or GCN4pII-Stag, was then inserted to the pRTRA cloning vector under the control of the 35S CaMV promoter. After that, the whole cassete was inserted into the pCB301 vector and transformed into Agrobacterium tumefaciens for transient expression on Nicotiana benthamiana. The expression of recombinant S1 proteins in tobacco was determined by Western blot. The results showed that the expression levels of S1 trimer and S1 trimer S-tag proteins were equal in plants, which also indicated that S-tag fusion did not affect the expression level of the S1 protein. However, the expression level of S1 proteins was relatively low, reaching 0.005% of total soluble protein. In addition, the expression of S1 trimer S-tag protein and Sprotein-tp protein by co-transformation of two A. tumefaciens strains containing corresponding vectors in plants were also determined by Western blot. This is a premise study for the development of subunit vaccines in plants that prevent the spread of PEDV.
Expression of genes involved in immune regulation in chronic myeloid leukemia
Authors: Giang Nguyen Hoang , Thanh Huyen Nguyen , Xuan Nguyen Thi
Published: July 2021

Chronic myeloid leukemia (CML) is a blood cancer involved in abnormal proliferation of myeloid cells at all stages of differentiation. Translocation of regions of the BCR and ABL genes, leading to the fusion gene BCR-ABL, which forms the Philadelphia (Ph) chromosome, is the cause of more than 90% of CML. The BCR-ABL protein shows abnormal tyrosine kinase activity, leading to changes in proliferation signals including signal transducer and activator of transcriptions (STATs) and nuclear factor kappa-light-chain-enhancer of activated B (NF-κB) and resulting in uncontrolled proliferation of myeloid cells. CTLA-4, PD-1 and LAG3 genes are known as immunosuppressive receptors playing important roles in controlling immune response by inhibiting activity of T helper cells. Klotho gene has anti-aging, anti-inflammatory and anti-cancer functions. STAT signaling pathway genes regulate cancer cell functions by their phosphorylation and IκB-α gene by degradation of its expression. In this study, we conducted experiments to determine mRNA expression of these genes on immune cells in CML patients by using realtime-PCR. Results showed a marked increase in the expression of STAT-1 and STAT-6 signaling genes and a decreased LAG3 expression in CML patients as compared with healthy controls. In addition, other gene expressions such as CTLA4, PD1, klotho, IκB-α, STAT3 and STAT5 were unaltered in CML cells. The abnormal increased expression of STAT1 and STAT6 genes indicated an important role of these signaling genes in regulating activity of immune cells, leading to pathogenesis and development of CML disease. The evidence suggested that STAT-1 and STAT-6 genes could be important and potential markers in early prognosis of CML.
Computed tomography angiography of the coronary arteries: major findings in the clinical routine of a general hospital
Authors: Souto Rafael Mansur , Santos Alair Augusto Sarmet Moreira Damas dos , Nacif Marcelo Souto
Published: July 2021

Abstract Almost two decades ago, it became possible to use coronary computed tomography for the noninvasive assessment of the coronary arteries. That is an extremely accurate method for detecting or excluding coronary artery disease, even the subclinical forms. This pictorial essay aims to show the main imaging findings in 47 coronary computed tomography scans acquired at a general hospital between January 2014 and June 2018. The most common findings were atheromatous plaques (in 87%) and stents (in 34%). There were also incidental findings, not directly related to coronary artery disease, such as pulmonary nodules and aortic stenosis.
The role of magnetic resonance imaging in active surveillance of prostate cancer
Authors: Alagbe Olayemi Atinuke , Westphalen Antonio Carlos , Muglia Valdair Francisco
Published: July 2021

Abstract Active surveillance (AS) is an important strategy to avoid overtreatment of prostate cancer (PCa) and has become the standard of care for low-risk patients. The role of magnetic resonance imaging (MRI) in AS has expanded due to its ability to risk stratify patients with suspected or known PCa, and MRI has become an integral part of the AS protocols at various institutions. A negative pre-biopsy MRI result is associated with a very high negative predictive value for a Gleason score ≥ 3+4. A positive MRI result in men who are otherwise eligible for AS has been shown to be associated with the presence of high-grade PCa and therefore with ineligibility. In addition, MRI can be used to guide and determine the timing of per-protocol biopsy during AS. However, there are several MRI-related issues that remain unresolved, including the lack of a consensus and guidelines; concerns about gadolinium deposition in various tissues; and increased demand for higher efficiency and productivity. Similarly, the need for the combined use of targeted and systematic sampling is still a matter of debate when lesions are visible on MRI. Here, we review the current AS guidelines, as well as the accepted roles of MRI in patient selection and monitoring, the potential uses of MRI that are still in question, and the limitations of the method.