bluuebunny/crossref_metadata_2025 huggingface dataset:
الصورة الكتابية المخبوءة في القصيدة التفاعلية العربية إجراء وتطبيق
Authors: كاظم لفتة أ.م.د عواد
Published: November 2022

تستوحي النصوص الأدبية رؤيتها الفنية والجمالية من العوالم الذهنية والأسطورية والاجتماعية ، فضلاً عن المناخات الفكرية للكاتب ، وبعد التحولات الهائلة في الحياة المعاصرة تغيرت مرجعيات النصوص ووسائل تقديمها ، وظهرت إبداعات جديدة ، ولكن الإبداع ظل ممهوراً بالقدرة ((على الخلق والابتكار والتأليف والتخطيط والاستنباط مع إضافة التفاصيل إلى الفكرة بعيداً عن المألوف والعادي ، فهي قدرات التفكير المبدع ، ورؤاه الفنية ، وجهده الخالص ، وخياله الخصب نحو الطلاقة والمرونة والقدرة على إنتاج أفكار متميزة تحرك التلقي من مستوى تفكير إلى مستوى آخر أعلى في القيمة))(1).
ولقد كان الشعر العربي القديم ينتظم جمالياً وفنياً في آن واحد ، فالفكرة المميزة لا تعني ان يكون إخراجها مبعثراً ، ويبدو ان ذلك مما أوجب الوزن في الشعر العربي ، فالشفاهية ألزمت الشعر العربي القديم بالوزن ومن ثم فأن الوحدات الموسيقية في داخل البيت الشعري تحدد شكله الخارجي وفضاءه الوزني ، حتى ليكاد الوزن بتنغيماته المتنوعة ان يرسم الألفاظ ويسطرها في ذهن المتلقي ، فخلق فضاء كتابياً خيالياً ، ولا ينعدم ذلك بغياب القراءة ، ذلك ان الكتلة الموسيقية تحدد القالب الخارجي للبيت الشعري ، ومن هنا نفهم اقتران الوزن بالشعر إلا ما ندر(2).
إن وجود المحددات الوزنية في ذهن المتلقي يعني ان الخيال يؤام لحظة الإنشاد بين القالب الشعري الموسيقي والصور الفنية المنبلجة عنه ، فالشاعر يقع تحت تأثير سطوة الخيال ويستدر معجمه اللغوي ، وفي هذه الحال تكون الموسيقى الداخلية وحركة الأصوات واشية ببعض ما في الصورة من حركة، وبذلك تتضافر الحركة الداخلية للصورة
الصراع على البلطيق وحرب الشمال العظمى 1700 -1721
Authors: خوير مطرود م.د علي
Published: November 2022

شكلت الطبيعة الجغرافية في اغلب الاوقات عاملاً مهماً وحاسماً في تشكيل او عادة تشكيل الوجود التاريخي لأي دولة، بأبعدها السياسية والاجتماعية والاقتصادية، بل حتى الثقافية والدينية منها، فكثير ما كان الموقع الجغرافي لهذه الدولة او تلك يسهم بصورة رئيسة في تحديد مستقبل وجودها، وعلى الرغم مما منحته الطبيعة من مساحة جغرافية وقيمة مناخية كبيرتين لروسيا، غير انها بخلت عليها بمنحها رئة تتنفس منها القادم من أوربا، ومنعت عنها اي نافذة حقيقة تطل منها على السواحل الاوربية، ما يمكنها في نهاية المطاف من ان تتحول الى بلد اوربي بامتياز، وقد أدرك الكثير ممن اعتلوا عرش هذه الدولة تلك الحقيقة، فحاول قسم منهم بصورة او اخرى، فتح تلك النافذ وان كان بالقوة، ما دفعهم في اغلب الاحيان للدخول في صراعات وحروب كلفتهم الكثير، ولان اغلب حركة التاريخ ومساراته ترتبط بوجود شخص ذو ميزات خاصة تمكنه من رسم، أو اعادة رسم حركة التاريخ، فان حلم روسيا الازلي بالحصول على موطأ قدم على سواحل البلطيق، ارتبط بظهور بيتر المعروف بالعظيم، فمما لاشك في قوله ولا تردد، ان الرجل هو من منح روسيا ما هي عليه اليوم من القوة والمكانة والحضارة بمختلف تسمياتها ومسمياتها، اذ نجح من انتشال روسيا من وحل التخلف الحضاري ليضعها في قمة سلم التطور الذي جاوزت به احيانا جارتها أوربا.
أثر المياه في العمليات والخطط العسكرية في حروب التحرير (العراق والشام انموذجاً)
Authors: خيري كاظم م.د فوزي
Published: November 2022

استخدمت المياه الأنهار كعامل من العوامل الجغرافية المهمة في التأثير على المعارك العسكرية من خلال التدخل البشري فيها، وقد تنوع أسلوب استخدامها بين أن يتم وضعها ضمن الخطة العسكرية لقائد الحملة واعتبارهما جزءاً منها، وبين أن يستثمر وجود الموانع المائية المتمثلة بمياه الأنهار، ويضعها كحاجز بين جيشه وبين أعدائه، أو تنظيم عملية اجتياز النهر بكيفية تخدم خطته الحربية التي وضعها مسبقاً، وتنظيم ذلك بالكيفية التي تخدم حملته هذه . ولكون وجود الأنهار ومصادر المياه الأخرى في العراق وبلاد الشام بكثرة، وقد عمل قواد جيوش الفتح على استثمارها بوضع الخطط الحربية المناسبة لتوظيفها بالشكل الذي يخدم خططهم، وما لذلك من أثر في الانتصارات الكبيرة التي تحققت فيها، ولتسليط الضوء أكثر على أثر المياه في العمليات العسكرية ووضع الخطط الحربية في تلك المرحلة المهمة من تاريخ الدولة الاسلامية، فقد اتخذناه ليكون موضوعاً لبحثنا هذا، وأسميناه ((أثر المياه في العمليات والخطط العسكرية في معارك التحرير (العراق والشام إنموذجاً)) .
دور دراسة التأريخ في تنمية القيم الداعمة لمفهوم المواطنة لدى طلبة قسم التاريخ من وجهة نظر هم
Authors: عبيس الشافعي صادق
Published: November 2022

يهدف البحث الحالي التعرف :1- التعرف على اهم القيم الداعمة لمفهوم المواطنة.2- التعرف على دور دراسة التاريخ في تنمية القيم الداعمة لمفهوم المواطنة لدى طلبة قسم التاريخ من وجهة نظرهم .3- التعرف على الفروق في استجابات افراد العينة على الدور الذي تقوم به دراسة التاريخ في تنمية القيم الداعمة لمفهوم المواطنة وفقاً لمتغير الجنس ( ذكور- إناث )تكون مجتمع البحث من طلبة قسم التاريخ في كلية التربية للعلوم الإنسانية في جامعة كربلاء والبالغ عددهم (268) طالباً وطالبةً , اختار الباحث منهم طلبة المرحلة الرابعة في الدراسة الصباحية, عينة قصدية لبحثه كونهم أصبحوا يمتلكون المشاعر والمعتقدات والتصورات التي يمكن تساعدهم في معرفة مدى اسهام دراسة التاريخ في تنمية القيم الداعمة لمفهوم المواطنة . وقد بلغ عددهم (63) طالباً وطالبة, واستعمل الاستبانة أداة للبحث , وقد تكونت من ( 75) فقرة موزعة على اثنتي عشرة قيمة ,وقد تم التأكد من صدقها وثباتها , ولمعالجة بيانات البحث استخدم الباحث طرقاً إحصائية وصفية وتحليلية مستفيداً من استخدام برنامج الرزمة الإحصائية للعلوم الاجتماعية (Spss ).. وأظهرت النتائج أن لدراسة التاريخ دور في تنمية القيم الداعمة لمفهوم المواطنة وبدرجة كبيرة من وجهة نظر افراد العينة البحث كما اظهرت النتائج عدم وجود فروق ذات دلالة احصائية بين استجابات افراد عينة البحث تعزى لمتغير الجنس. وفي ضوء نتائج البحث وضع الباحث مجموعة من التوصيات منها:-1- اعادة النظر في سلامة الاهداف التربوية لدراسة التاريخ في التعليم الجامعي ومحاولة تطويرها وبما يسهم في تعزيز وتنمية قيم المواطنة الصالحة لدى الطلبة .2- على من يتخصص بتدريس التاريخ ان لا يغفل الجانب الوجداني للتاريخ فهو الذي يدفع افراد المجتمع الى التضحية والفداء من اجل الوطن .
The Multi-fold Theory: A synopsis
Authors: Maes Stephane
Published: November 2022

This paper provides a synopsis and review of the multi-fold theory in preparation for more detailed reviews lectures and books. In a multi-fold universe, gravity emerges from Entanglement through the multi-fold mechanisms. As a result, gravity-like effects appear in between entangled particles that they be real or virtual. Long range, massless gravity results from entanglement of massless virtual particles. Entanglement of massive virtual particles leads to massive gravity contributions at very smalls scales. Multi-folds mechanisms also result into a spacetime that is discrete, with a random walk fractal structure and non-commutative geometry that is Lorentz invariant and where spacetime nodes and particles can be modeled with microscopic black holes. All these recover General Relativity (GR) at large scales and semi-classical model remain valid till smaller scale than usually expected. Gravity can therefore be added to the Standard Model resulting into what we defined as SMG. This can contribute to resolving several open issues with the Standard Model without new Physics other than gravity. These considerations hints at an even stronger relationship between gravity and the Standard Model.Among the multi-fold SMG discoveries, the apparition of an-always in-flight, and hence non-interacting, right-handed neutrinos, coupled to the Higgs boson is quite notable. It is supposedly always around right-handed neutrinos, due to chirality flips by gravity of the massless Weyl fermions, induced by 7D space time matter models and hidden behind the Higgs boson or field at the entry points and exit points of the multi-folds. Massless Higgs bosons modeled as minimal microscopic black holes mark concretized spacetime location. They can condensate into Dirac Kerr-Newman soliton Qballs to produce massive and charged particles, thereby providing a microscopic explanation for a Higgs driven inflation, the electroweak symmetry breaking, the Higgs mechanism, the mass acquisition and the chirality of fermions and spacetime; all resulting from the multi-fold gravity electroweak symmetry breaking. The multi-fold theory has also concrete implications on New Physics.We see this paper as a draft to collect comment and feedback as we evolve it towards a fuller publication.It is the End of 2021 version.
Child physical abuse risk factors: A systematic review and a meta-analysis
Authors: Milner Joel S. , Crouch Julie L. , McCarthy Randy J. , Ammar Joe , Dominguez-Martinez Rodrigo , Thomas Courtney L. , Jensen Audra Paige
Published: November 2022

Child physical abuse (CPA) is a pervasive societal problem with serious outcomes. Understanding CPA risk factors is necessary to identify those at risk for CPA perpetration and to inform efforts to prevent the occurrence of CPA. The present study provides an updated review of conceptual models of CPA, a review of model-related CPA risk factors, and a meta-analytic review of CPA risk factors found in cross-sectional, case-controlled studies. The review of conceptual models yielded >70 explanatory models of CPA from which >140 putative CPA risk factors were extracted. A three-level random-effects meta-analysis of CPA risk factors was conducted. Database and literature searches yielded 58 studies that met the inclusion criteria from which 300 effect size (ES) estimates were identified. In the meta-analysis, 292 ESs were placed into 38 CPA risk factor domains. Twenty significant individual CPA risk factor domain ES estimates and five significant relationship CPA risk factor domain ESs were found. Future studies that simultaneously consider CPA risk and protective factors from within and between ecological levels and that establish causal CPA factors are needed to better inform CPA prevention and treatment efforts.
To overcome gender inequality in legal education: Ethical awareness
Authors: Uygur Gülriz , Özdemir Nadire
Published: November 2022

We claim that to combat stereotyping regarding gender inequalities in law, students should gain ethical awareness which includes awareness of prejudices and stereotypes. For this reason, we organized our clinical legal education in such a way as to combat students’ bias and make a transformation. In our lectures we used transformative methodology that includes intersectional analysis. In this article we explain our educational experience and describe our courses with its main principles.
At the origins of feminism: Ideas of Olympe de Gouges in the context of radical egalitarian doctrines of the French Revolution (1789–1794)
Authors: Mańka Dariusz
Published: November 2022

The article aims to present and analyze political and legal thought of Olympe de Gouges, a French revolutionary activist, who is considered one of the most important precursors of modern feminism. Her writings should be situated in the context of radical egalitarian doctrines, influential during the Enlightenment and the French Revolution. The paper also shows an impact of this pre-feminist thought on the private and public law of the Revolution. Las part is devoted to a comparison of de Gouges’ ideas with some contemporary feminist discourses.
Dietitians Working in Continuing Care Facilities in Nova Scotia: Pre- and Post-COVID-19 First Wave
Authors: Mann Linda , Syed Safura , Waugh Rachel
Published: November 2022

Continuing care (CC) facilities have been impacted by a growing demand for services, insufficient resources for the provision of quality food and nutrition care, and, most recently, the COVID-19 pandemic. This study explored the roles and responsibilities of dietitians working in CC facilities in Nova Scotia (NS) before and after the COVID-19 first wave. Using ethics-approved questionnaires, the estimated 75 dietitians working in CC facilities in NS were surveyed in Fall 2019 and Fall 2020 about their roles and responsibilities. Twenty responded to the first questionnaire and 15 to the second. Analysis of data included simple statistical and qualitative description methods. The findings highlighted the complexities and challenges faced by these dietitians in the provision of resident nutrition care, overseeing foodservices, training staff and dietetic interns, and contributing to facility specific care committees before and after the COVID-19 first wave. There is a need to advocate for minimum standards for dietetic and foodservice funding in CC facilities based on higher acuity and complex care needs of residents and considering the multifaceted roles of dietitians in CC. Efforts to improve awareness about the roles of dietitians working in CC among resident families, other dietitians, and dietetic interns are also needed.
Prenatal Nutrition Care in Alberta: The Perspectives of Pregnant Women and Registered Dietitians
Authors: Misita Dragana , Aulakh Sharan , Jain Venu , Quintanilha Maira , Ospina Maria B. , Bell Rhonda C.
Published: November 2022

Introduction: Optimizing women’s diets in pregnancy improves maternal and child health outcomes; however, the best format for supporting women’s nutrition goals in pregnancy is not clear, and access to dietetic services is not standard in prenatal care in Alberta. This study explored women’s perceptions about access to Registered Dietitians (RDs) throughout pregnancy and RDs experiences providing prenatal nutrition counselling.

Methods: Two studies were conducted. Study A: Pregnant women completed a short survey while attending a prenatal appointment in a large prenatal clinic. The survey assessed women’s perspectives about accessing dietetic services during pregnancy. Survey data were analyzed using descriptive statistics. Study B: RDs participated in either a semi-structured phone interview or a focus group and described their experiences working with pregnant women. Data were analyzed using thematic analysis.

Results: One hundred pregnant women completed the survey. Ninety percent indicated that they had not seen a RD at this time in pregnancy, and 48% reported that they would like to access a RD in pregnancy, if available. Dietitians discussed the diversity of women’s concerns and the challenges to providing prenatal nutrition support.

Conclusions: Women have nutrition-related questions during pregnancy. Dietitians experience challenges providing services in the current care systems.
Internalisasi Nilai Moderat Dalam Membangun Kerukunan Masyarakat Lamongan
Authors: Muflich Moch Faizin , Nurhayati Binti
Published: November 2022

The diversity of society tends to be a burden rather than a source of strength for the Indonesian state in the current reform era. The current state of people's tastes and attitudes is a setback from what has happened in the past. The lack of commitment to use tolerance as a strategy to overcome various issues that contribute to the country's decline leads to intolerance. This is contrary to what the peaceful residents of Balun Turi Lamongan do. The religious community in this village which consists of Muslims, Hindus, and Christians shows the unique approach of the Balun people in respecting diversity and tolerance by living side by side peacefully and participating in interfaith celebrations. This does not escape the process of internalizing or inculcating moderate values ​​that are carried out in the village of Balun through three phases, namely, the value transformation phase, value transaction, and value transinternalization so that the moderate value produced is in the form of tasamuh value, shura value, i' tidal value. value, the value of musawah, and the value of wataniyah and muwatanah.
التنظيم المعرفي للانفعال والتفاؤل والسعادة والحِكمَة
Authors: K. Ghabr Luai
Published: November 2022

الحكمة هي تطبيق الذكاء الناجح والإبداع – تتوسطهما القيم – من أجل تحقيق نفع عام، من خلال الموازنة بين: المصالح الشخصية (الفردية الذاتية) وبين الشخصية (الاجتماعية) وخارج الشخصية (المجتمعية السياقية)، عبر المديين القصير والطويل، من أجل تحقيق توازن بين: التكيف مع البيئة الموجودة، وتشكيل تلك البيئة، واختيار بيئة جديدة. فعملت الدراسة الحالية على استكشاف البنية العميقة للحكمة عبر تعرُّف العلاقات الارتباطية والتنبؤية بين استراتيجيات التنظيم المعرفي للانفعال والتفاؤل والسعادة والحكمة . فطبَّقت استبانة التنظيم المعرفي للانفعال CERQ-SV لـ Garnefski & Kraaij 2006، واختبار توجُّه الحياة LOT-R لـ Scheier, Carver & Bridges 1994، ومقياس السعادة HS لـ Springer & Hauser 2006، ومقياس الحكمة ثلاثي الأبعاد 3D-WS لـ Ardelt 2003 ، على عينة (134) من طلبة الجامعة . فظهرت نتائج عدَّة، منها : أغلب الاستراتيجيات المعرفية لتنظيم الانفعال – الايجابية والسلبية – ناشطة، وارتفاع التفاؤل، وارتفاع / اعتدال السعادة، واعتدال الحكمة، وارتباطات سلبية بين الاستراتيجيات السلبية وكل من السعادة والحكمة، وايجابية مع التفاؤل والسعادة، وارتبطت الحكمة بالسعادة ايجابياً، وبالتفاؤل سلبياً، وفي العلاقات التنبؤية أسهمت المتغيرات الثلاثة في التنبؤ بالحكمة : الاسترتيجيات بالمعرفي والوجداني، والتفاؤل بالمعرفي والوجداني، والسعادة بالمعرفي والتأملي والوجداني . وانتهت إلى استنتاج إجمالي مفاده إنَّ الحكمة تتحقَّق عند استعمال الاستراتيجيات المعرفية الايجابية لتنظيم الانفعالات، والتخفيف من التفاؤلية، والامتلاء بالمعنى والهدف وتقبل الذات والعلاقات الايجابية
Polygenic Liability to Alzheimer’s Disease Is Associated with a Wide Range of Chronic Diseases: A Cohort Study of 312,305 Participants
Authors: Wu Bang-Sheng , Zhang Ya-Ru , Yang Liu , Zhang Wei , Deng Yue-Ting , Chen Shi-Dong , Feng Jian-Feng , Cheng Wei , Yu Jin-Tai
Published: November 2022

Background: Alzheimer’s disease (AD) patients rank among the highest levels of comorbidities compared to persons with other diseases. However, it is unclear whether the conditions are caused by shared pathophysiology due to the genetic pleiotropy for AD risk genes. Objective: To figure out the genetic pleiotropy for AD risk genes in a wide range of diseases. Methods: We estimated the polygenic risk score (PRS) for AD and tested the association between PRS and 16 ICD10 main chapters, 136 ICD10 level-1 chapters, and 377 diseases with cases more than 1,000 in 312,305 individuals without AD diagnosis from the UK Biobank. Results: After correction for multiple testing, AD PRS was associated with two main ICD10 chapters: Chapter IV (endocrine, nutritional and metabolic diseases) and Chapter VII (eye and adnexa disorders). When narrowing the definition of the phenotypes, positive associations were observed between AD PRS and other types of dementia (OR = 1.39, 95% CI [1.34, 1.45], p = 1.96E-59) and other degenerative diseases of the nervous system (OR = 1.18, 95% CI [1.13, 1.24], p = 7.74E-10). In contrast, we detected negative associations between AD PRS and diabetes mellitus, obesity, chronic bronchitis, other retinal disorders, pancreas diseases, and cholecystitis without cholelithiasis (ORs range from 0.94 to 0.97, FDR < 0.05). Conclusion: Our study confirms several associations reported previously and finds some novel results, which extends the knowledge of genetic pleiotropy for AD in a range of diseases. Further mechanistic studies are necessary to illustrate the molecular mechanisms behind these associations.
Diencephalic versus Hippocampal Amnesia in Alzheimer’s Disease: The Possible Confabulation-Misidentification Phenotype
Authors: Abbate Carlo , Trimarchi Pietro D. , Fumagalli Giorgio G. , Gallucci Alessia , Tomasini Emanuele , Fracchia Stefania , Rebecchi Isabella , Morello Elisabetta , Fontanella Anna , Parisi Paola M.R. , Tartarone Federica , Giunco Fabrizio , Ciccone Simona , Nicolini Paola , Lucchi Tiziano , Arosio Beatrice , Inglese Silvia , Rossi Paolo D.
Published: November 2022

Background: Alzheimer’s disease (AD) is clinically heterogeneous, including the classical-amnesic (CA-) phenotype and some variants. Objective: We aim to describe a further presentation we (re)named confabulation-misidentification (CM-) phenotype. Methods: We performed a retrospective longitudinal case-series study of 17 AD outpatients with the possible CM-phenotype (CM-ADs). Then, in a cross-sectional study, we compared the CM-ADs to a sample of 30 AD patients with the CA-phenotype (CA-ADs). The primary outcome was the frequency of cognitive and behavioral features. Data were analyzed as differences in percentage by non-parametric Chi Square and mean differences by parametric T-test. Results: Anterograde amnesia (100%) with early confabulation (88.2%), disorientation (88.2%) and non-infrequently retrograde amnesia (64.7%) associated with reduced insight (88.2%), moderate prefrontal executive impairment (94.1%) and attention deficits (82.3%) dominated the CM-phenotype. Neuropsychiatric features with striking misidentification (52.9%), other less-structured delusions (70.6%), and brief hallucinations (64.7%) were present. Marked behavioral disturbances were present early in some patients and very common at later stages. At the baseline, the CM-ADs showed more confabulation (p < 0.001), temporal disorientation (p < 0.02), misidentification (p = 0.013), other delusions (p = 0.002), and logorrhea (p = 0.004) than the CA-ADs. In addition, more social disinhibition (p = 0.018), reduction of insight (p = 0.029), and hallucination (p = 0.03) persisted at 12 months from baseline. Both the CA- and CM-ADs showed anterior and medial temporal atrophy. Compared to HCs, the CM-ADs showed more right fronto-insular atrophy, while the CA-ADs showed more dorsal parietal, precuneus, and right parietal atrophy. Conclusion: We described an AD phenotype resembling diencephalic rather than hippocampal amnesia and overlapping the past-century description of presbyophrenia.
Routing optimization algorithm based on mobile agent for wireless sensor networks
Authors: Chen Dongya
Published: November 2022

A routing model about mobile agent in sensor networks was drawn out, and an optimization problem of mobile agent static route was derived. In order to optimize the route of mobile agent, a target location algorithm in wireless sensor networks was proposed. All the sensor nodes which know target compete to get the mobile agent in order to track the location of targets. Competition rules are defined by the remaining value of the energy and the distance between the nodes and the target. Simulation results showed that this algorithm could provide less energy consumption compared to other schemes and prolong survival cycle time. It balances the network energy, reduces the amount of data transmission in the network, reduces the network energy overhead, prolongs the lifetime of the entire network, and effectively reduces the network delay.
Soft isomorphism for digital images and computational topological applications
Authors: Öztunç Simge , İhtiyar Sultan
Published: November 2022

In this paper the concept of soft continuity is focused on for digital images by using soft sets which is defined on κ - adjacent digital images. Also the definitions of digital soft isomorphism and digital soft retraction are given. Some theorems are obtained deal with soft isomorphism and soft retraction for digital images and some numerical examples are presented in dimension 2. Finally digital soft retraction is obtained as a soft topological invariant.
Improved rank discrepancy-aware sampling based on bidirectional distillation for top-K recommender system
Authors: Du Weidong
Published: November 2022

Nowadays, the model compression method of knowledge distillation has drawn great attentions in Recommender systems (RS). The strategy of bidirectional distillation performs the bidirectional learning for both the teacher and the student models such that these two models can collaboratively improve with each other. However, this strategy cannot effectively exploit representation capabilities of each item and lack of the interpretability for the importance of items. Thus, how to develop an effective sampling scheme is still valuable for us to further study and explore. In this paper, we propose an improved rank discrepancy-aware item sampling strategy to enhance the performance of bidirectional distillation learning. Specifically, by employing the distillation loss, we train the teacher and student models to reflect the fact that a user has partiality for the unobserved items. Then, we propose the improved rank discrepancy-aware sampling strategy based on feedback learning mechanism to transfer just the useful information which can effectively enhance each other. The key part of the multiple distillation training aims to select valuable items which can be re-distilled in the network for training. The proposed technique can effectively solve the problem of high ambiguity in nature for recommender system. Experimental results on several real-world recommender system datasets well demonstrate that the improved bidirectional distillation strategy shows better performance.
Near zero fuzzy solution of fully fuzzy linear systems1
Authors: Guo Xiaobin , Liu Kun
Published: November 2022

This paper discusses a new approximate solution of a class of fully fuzzy linear systems A ˜ x ˜ = b ˜ in which the coefficient matrix A ˜ is a positive fuzzy matrix. The original fuzzy linear systems is extended into simple crisp linear equation using the obtained approximate multiplication of positive fuzzy number and near zero fuzzy number. Two cases are analysed: (a) the unknown vector x ˜ is a near zero fuzzy vector with positive mean value; (b) the unknown vector x ˜ is a near zero fuzzy vector with negative mean value. Two computing models are established and respective expression of the solution to fully fuzzy linear system are derived, and the sufficient condition for the existence of strong fuzzy solution are analyzed correspondingly. Some numerical examples are given to illustrated our proposed method.
Kronik Faz KML Hastalarında Bosutinib Kullanımı: Tek Merkez Deneyimi
Authors: GÜLLÜ KOCA Tuba , PINAR İbrahim Ethem , ERSAL Tuba , YALÇIN Cumali , ORHAN Bedrettin , CANDAR Ömer , ÇUBUKÇU Sinem , HUNUTLU Fazıl Cagrı , ALİ Rıdvan , OZKOCAMAN Vildan , ÖZKALEMKAŞ Fahir
Published: November 2022

Kronik Myeloid Lösemide (KML), etyolojisinde sorumlu tirozin kinaz aktivitesi gösteren bcr-abl füzyon geninin keşfinden sonra, bu aktiviteyi inhibe eden ilaçların keşfiyle, daha uzun sağkalım sürelerine ulaşılabilmiştir. Bu ilaçlarla tedaviye zamanla direnç gelişmesi, ikinci ve üçüncü kuşak ajanların geliştirilmesinin önünü açmıştır. Bu çalışmamızda, merkezimizde ikinci kuşak tirozin kinaz inhibitörü (TKİ) – bosutinib - tedavisi alan hastaların, klinik, laboratuvar, moleküler yanıt, yan etki profili ve mortalite üzerindeki etkilerini değerlendirmeyi amaçladık. KML nedeniyle bosutinib tedavisi başlanan 17 hasta çalışmaya dahil edildi. Hastaların tedaviye kaçıncı sırada başlandığı, klinik, laboratuvar ve moleküler yanıt durumları retrospektif olarak elektronik hasta kayıtlarından tarandı. Elde edilen veriler hastaların ilaç başlanma sırasına göre karşılaştırıldı. İkinci (n=2), üçüncü (n=7) ve dördüncü (n=8) sırada bosutinib başlanan hastaların yaş, cinsiyet, komorbidite sayısı, bosutinib tedavi süresi açısından anlamlı bir fark gözlenmezken KML tanı yaşları arasında anlamlı bir farklılık mevcuttu. Moleküler yanıt ve yan etki profili açısından değerlendirildiğinde, ilacın başlanma sırası ile anlamlı bir farklılık yoktu. Hastaların genel sağkalımı 43,38 ± 4,98 ay (%95 GA: 33,62 – 53,16 ay) olarak gözlemlendi. Bosutinib tedavisinin her yaş grubunda, ilacın her başlanma sırasında kullanımının, stabil moleküler yanıt sağlaması açısından güvenli olduğu gözlemlendi. Yan etki profili açısından kullanımını sınırlayacak bir profile sahip olmaması nedeniyle KML tedavisinde tercih edilebilir bir molekül olarak düşünülmelidir.
A gestão de recursos humanos nas empresas
Authors: Souza Thaísa Santos de , Miranda Mateus Torres , Silva Suziane Ferreira da , Roberto José Carlos Alves , Pinto Junior José Roberto Lira
Published: November 2022

Sabe-se que gerir pessoas dentro das organizações não é uma tarefa fácil, pois cada ser possui comportamentos, crenças e hábitos diferentes entre si. Entretanto, investir em capital humano é um fator crucial para que as empresas se tornem competitivas dentro do ambiente de negócios. Nesse contexto, o presente artigo, tem como questão norteadora: como a gestão de recursos humanos pode ajudar a empresa? Tendo como objetivo trazer conceitos relacionados ao funcionamento e aplicabilidade da gestão de recursos humanos no ambiente empresarial. Para isso, realizou-se uma revisão bibliográfica. Por fim, constatou-se que a gestão de pessoas garante que os colaboradores fiquem engajados e comprometidos com a organização, sendo essencial para as organizações se desenvolverem e se tornarem mais competitivas.
Lean six sigma: qualidade total e indústria 4.0
Authors: Viana Riviany Araújo
Published: November 2022

O objetivo deste trabalho é descrever sobre o Lean Six Sigma no processo produtivo. Uma revisão de escopo pela metodologia Prisma foi escolhida para realizar esta avaliação, apresentando como vantagem ser capaz de combinar ambos resultados de estudos empíricos quantitativos e escritos qualitativos. Além disso, a comparação e os contrastes entre os resultados da pesquisa enriquecem o relatório no conhecimento atual diante de um tema específico e torna possível tecer conclusões esclarecedoras para a prática. Um sistema Lean é completamente diferente do conceito da Indústria 4.0, pois enquanto o primeiro tem a capacidade de mudar completamente um modelo de produção, o segundo melhora o fluxo de informações. Mas a conjunção de ambos pode, e certamente deve criar sinergias positivas para as indústrias que as aplicam. Em indústrias ou empresas que precisam de melhorias nos processos, as ferramentas DMAIC, precisamente ferramentas de análise de causas básicas como o conhecido diagrama espinha de peixe, são ferramentas que são fundamentais na identificação do que afetam o processo.
МЕДИЧНЕ СТРАХУВАННЯ ЯК ІНСТРУМЕНТ ЗАБЕЗПЕЧЕННЯ ДЕМОГРАФІЧНОЇ БЕЗПЕКИ КРАЇНИ
Authors: Юрченко О.А. , Свирида О.А. , Ковальчук С.С.
Published: November 2022

Розглянуто сутність терміну «медичне страхування», охарактеризовано його економічні та соціальні функції. Окреслено роль медичного страхування у забезпеченні демографічної безпеки країни. Проаналізовано частку добровільного медичного страхування в структурі страхового портфеля. Розглянуто стандартний перелік страхових медичних послуг. Узагальнено економічні інтереси учасників ринку добровільного медичного страхування: страховиків, лікувально-профілактичних установ, застрахованих осіб та роботодавців, що страхують своїх працівників. Окреслено проблеми добровільного медичного страхування та перешкоди для його розвитку в Україні. Зроблено висновок про необхідність впровадження в Україні обов’язкового медичного страхування як більш дієвого при формуванні фінансового забезпечення функціонування галузі охорони здоров’я.
The remote diet intervention to reduce Long COVID symptoms trial (ReDIRECT): protocol for a randomised controlled trial to determine the effectiveness and cost-effectiveness of a remotely delivered supported weight management programme for people with Long COVID and excess weight, with personalised improvement goals
Authors: Haag Laura , Richardson Janice , Cunningham Yvonne , Fraser Heather , Brosnahan Naomi , Ibbotson Tracy , Ormerod Jane , White Chris , McIntosh Emma , O'Donnell Kate , Sattar Naveed , McConnachie Alex , Lean Michael E. J. , Blane David N. , Combet Emilie
Published: November 2022

Objectives: The Remote Diet Intervention to Reduce Long COVID Symptoms Trial (ReDIRECT) evaluates whether the digitally delivered, evidence-based, cost-effective Counterweight-Plus weight management programme improves symptoms of Long COVID in people with overweight/obesity.

Methods: Baseline randomised, non-blinded design with 240 participants allocated in a 1:1 ratio either to continue usual care or to add the remotely delivered Counterweight-Plus weight management programme, which includes a Counterweight dietitian supported delivery of 12 weeks total diet replacement, food reintroduction, and long-term weight loss maintenance. Randomisation is achieved by accessing a web-based randomisation system incorporated into the study web portal developed by a registered Clinical Trials Unit. We are using an innovative approach to outcome personalisation, with each participant selecting their most dominant Long COVID symptom as their primary outcome assessed at six months. Participants in the control arm enter the weight management programme after six months. We are recruiting participants from social media and existing networks (e.g., Long COVID Scotland groups), through newspaper advertisements and from primary care. Main inclusion criteria: people with Long COVID symptoms persisting > three months, aged 18 years or above, body mass index (BMI) above 27kg/m2 (>25kg/m2 for South Asians). The trial includes a process evaluation (involving qualitative interviews with participants and analysis of data on dose, fidelity and reach of the intervention) and economic evaluation (within-trial and long-term cost-utility analyses).

Anticipated results: The recruitment for this study started in December 2021 and ended in July 2022. Project results are not yet available and will be shared via peer-reviewed publication once the six-months outcomes have been analysed.

Trial registration: Current Controlled Trials ISRCTN12595520
Citizen’s Charter in Public Services: Development, Principles and Practice
Authors: Rushni Korishi  , Buddha Dev Biswas  , Mizanur Rahman
Published: November 2022

This paper presents the consequences and development of the citizen’s charters over the decades after their introduction in the United Kingdom (UK) on 22 July 1991. It has used a systematic literature review to organize and present the development process of the citizens’ charter over the years. It does not focus on or target any specific zone or state but is initiated more to connect the links between Commonwealth nations. However, the citizen’s charter is a process to link citizens and public administrators in a more formal/official manner. It has changed a lot over the last three decades. The paper tried to critically investigate the degree of change, development, and practice.
Chemical and biological vertical distributions within central Arctic (>82°N) sea ice during late summer
Authors: Torstensson A , Showalter GM , Margolin AR , Shadwick EH , Deming JW , Smith WO
Published: November 2022

We assessed the distribution of biota (autotrophs and heterotrophs) and associated carbonate chemistry variables in Arctic sea ice at latitudes >82°N during late summer and early autumn 2018. The sampled sea ice was relatively thick (average 1.4 m) with variable snow cover (mean 7 cm) and low bulk salinities throughout. Most measured variables, including carbonate chemistry parameters, were low in the upper half of the ice cores, but increased with depth. Measurements of particulate organic carbon (POC), chlorophyll a (chl a), bacterial abundance, and particulate extracellular polysaccharide (pEPS) in the cores strongly suggested that detrital carbon was the major particulate organic pool. Near the ice-water interface, autotrophic material comprised ca. 50% of the total POC, whereas pEPS and bacterial carbon accounted for ca. 8 and 1% of the total POC, respectively. Under-ice water was nutrient poor, providing only a small input of nutrients to support autotrophic growth, at least during the time of our sampling. While the Arctic Ocean has substantial interannual variability in sea-ice concentration and thickness, these measurements enrich the available database and suggest that during years when autumn sea ice is >1 m thick, sea-ice biota are limited in activity and biomass.
Política pública de discapacidad en el Ecuador programa Manuela Espejo: una reflexión desde la teoría y la práctica
Authors:   Universidad Central del Ecuador, Lasso Molina Jorge Fernando , Folleco Chalá Johnson Marcelo ,   Universidad Central del Ecuador
Published: November 2022

La política pública constituye una definición de lo que el Estado hace o piensa hacer respecto de la satisfacción de una o varias necesidades de un grupo específico de la población, el campo de acción de la política pública se encuentra restringido al menos por dos factores: el primero, que es el real y efectivo, constituido por el dimensionamiento del problema público a confrontar, y el segundo los recursos disponibles para realizarlo. Si además se considera la variable tiempo es posible comprender lo difícil, pero satisfactorio, de implementar una política pública que por sus propias características es de largo plazo. Con este antecedente se utilizan algunos conceptos del ciclo de la política pública para analizar el Programa Manuela Espejo, parte del Plan Toda una Vida y que se ejecuta a través del esquema denominado “Las Manuelas” para afrontar el problema público de la discapacidad. De esta forma al cruzar la teoría con la práctica es posible obtener algunos insumos para la reflexión y el análisis, entre ellos que considerando las limitaciones de actuación del Estado, la política pública debe ser un proceso dinámico y proactivo, en una línea de tiempo debe vincular pasado-presente-futuro, por tanto se vuelve un concepto que abarca a varias generaciones.
La silla vacía y el derecho constitucional de participación ciudadana en la gestión pública de los gobiernos autónomos descentralizados municipales.
Authors:   Pontificia Universidad Católica del Ecuador, Pomagualli Quinchuela Juan Oswaldo , Salazar Sánchez Wagner Guillermo ,   Pontífica Universidad Católica del Ecuador
Published: November 2022

La silla vacía es un mecanismo y derecho constitucional que permite la participación ciudadana en las sesiones de los Concejos Municipales facilitando la participación ciudadana en los debates y que sus opiniones sean tenidas en cuenta a la hora de tomar decisiones sobre el desarrollo local y comunitario. El objetivo de la presente investigación fue evaluar la implementación de la silla vacía como mecanismo de participación ciudadana en la administración pública en el Gobierno Autónomo Descentralizado Municipal de Colta, Chimborazo, Ecuador. Para esto se realizó una investigación básica, no experimental y descriptiva. El universo estuvo constituido por 387 personas de las cuales 194 formaron parte de la muestra de investigación. Se revisó el estado de la implementación de la silla vacía en las sesiones del concejo municipal y se investigó sobre el nivel de conocimiento de la población relacionado con este tema. Los principales resultados incluyen un 60,56% de implementación de la silla vacía en las sesiones del Consejo Municipal y en el 25,35% se ejerció el derecho a la participación. El nivel predominante de conocimiento de la población sobre este mecanismo de participación ciudadana fue bajo (69,07%). El 77,84% de la población considera que no existen facilidades para la implementación de la silla vacía; el 89,69% de la población considera que se debe capacitar en este tema. Se concluye que el mecanismo de silla vacía, como derecho constitucional de la participación ciudadana, no está siendo adecuadamente utilizado como herramienta de gestión pública en el cantón Colta
CRISPR/Cas systems: Delivery and application in gene therapy
Authors: Huang Jie , Zhou Yitong , Li Jie , Lu Aiping , Liang Chao
Published: November 2022

The CRISPR/Cas systems in prokaryotes such as bacteria and archaea are the adaptive immune system to prevent infection from viruses, phages, or other foreign substances. When viruses or phages first invade the bacteria, Cas proteins recognize and cut the DNA from viruses or phages into short fragments that will be integrated into the CRISPR array. Once bacteria are invaded again, the modified CRISPR and Cas proteins react quickly to cut DNA at the specified target location, protecting the host. Due to its high efficiency, versatility, and simplicity, the CRISPR/Cas system has become one of the most popular gene editing technologies. In this review, we briefly introduce the CRISPR/Cas systems, focus on several delivery methods including physical delivery, viral vector delivery, and non-viral vector delivery, and the applications of disease therapy. Finally, some problems in CRISPR/Cas9 technology have been proposed, such as the off-target effects, the efficiency of DNA repair mechanisms, and delivery of CRISPR/Cas system safely and efficiently to the target location.
ALD-R491 regulates vimentin filament stability and solubility, cell contractile force, cell migration speed and directionality
Authors: Kim Hyejeong Rosemary , Warrington Samantha J. , López-Guajardo Ana , Al Hennawi Khairat , Cook Sarah L. , Griffith Zak D. J. , Symmes Deebie , Zhang Tao , Qu Zhipeng , Xu Ying , Chen Ruihuan , Gad Annica K. B.
Published: November 2022

Metastasizing cells express the intermediate filament protein vimentin, which is used to diagnose invasive tumors in the clinic. However, the role of vimentin in cell motility, and if the assembly of non-filamentous variants of vimentin into filaments regulates cell migration remains unclear. We observed that the vimentin-targeting drug ALD-R491 increased the stability of vimentin filaments, by reducing filament assembly and/or disassembly. ALD-R491-treatment also resulted in more bundled and disorganized filaments and an increased pool of non-filamentous vimentin. This was accompanied by a reduction in size of cell-matrix adhesions and increased cellular contractile forces. Moreover, during cell migration, cells showed erratic formation of lamellipodia at the cell periphery, loss of coordinated cell movement, reduced cell migration speed, directionality and an elongated cell shape with long thin extensions at the rear that often detached. Taken together, these results indicate that the stability of vimentin filaments and the soluble pool of vimentin regulate the speed and directionality of cell migration and the capacity of cells to migrate in a mechanically cohesive manner. These observations suggest that the stability of vimentin filaments governs the adhesive, physical and migratory properties of cells, and expands our understanding of vimentin functions in health and disease, including cancer metastasis.
Effects of inflammation and oxidative stress on postoperative delirium in cardiac surgery
Authors: Pang Yi , Li Yuntao , Zhang Yonggang , Wang Hongfa , Lang Junhui , Han Liang , Liu He , Xiong Xiaoxing , Gu Lijuan , Wu Xiaomin
Published: November 2022

The past decade has witnessed unprecedented medical progress, which has translated into cardiac surgery being increasingly common and safe. However, complications such as postoperative delirium remain a major concern. Although the pathophysiological changes of delirium after cardiac surgery remain poorly understood, it is widely thought that inflammation and oxidative stress may be potential triggers of delirium. The development of delirium following cardiac surgery is associated with perioperative risk factors. Multiple interventions are being explored to prevent and treat delirium. Therefore, research on the potential role of biomarkers in delirium as well as identification of perioperative risk factors and pharmacological interventions are necessary to mitigate the development of delirium.
Clinical presentation and in-hospital outcomes of intraoperative red blood cell transfusion in non-anemic patients undergoing elective valve replacement
Authors: Zhou Ren , Qian Dewei , Li Haiqing , Wang Zhe , Shi Sheng , Shen Feng , Cheng Lin , Yang Dicheng , Yu Min
Published: November 2022

Background

Intraoperative transfusion is associated with adverse clinical outcomes in cardiac surgery. However, few studies have shown the impact of intraoperative red blood cell (RBC) transfusion on non-anemic patients undergoing cardiac surgery. We assessed the in-hospital clinical outcomes of non-anemic patients undergoing isolated valve replacements and investigated the predictors associated with intraoperative RBC transfusion.

Methods

We enrolled 345 non-anemic patients undergoing isolated valve replacements in our department from January 2015 to December 2019. The patients were stratified by the receipt of intraoperative RBC transfusion. Baseline characteristics were compared between groups and multiple logistic regression was used to identify the predictors for intraoperative RBC transfusion. The association between intraoperative RBC transfusion and in-hospital outcomes was also evaluated.

Results

Intraoperative RBC transfusion developed in 84 of the 345 enrolled patients (24.3%). Three independent predictors for intraoperative RBC transfusion of non-anemic patients undergoing isolated valve replacements were identified by multivariate logistic analysis, including female, iron deficiency and hemoglobin level. When the two groups were compared, a significant tendency of higher in-hospital mortality (6.0% vs. 1.1%,P= 0.033) and higher incidence of postoperative hypoxemia (9.5% vs. 2.7%,P= 0.007) were observed in the intraoperative RBC transfusion group. After adjustment, the presence of intraoperative RBC transfusion was associated with an increase in postoperative hypoxemia (OR = 3.36, 95% CI: 1.16–9.71,P= 0.026).

Conclusion

Intraoperative RBC transfusion was associated with poorer clinical outcomes in non-anemic adults undergoing isolated valve replacements, which significantly increased the risk of postoperative hypoxemia. The independent predictors of intraoperative RBC transfusion, such as iron deficiency and female, were identified, which may be helpful for risk assessment and perioperative management.
Modelling the energy conservation behaviour among Chinese households under the premises of value-belief-norm theory
Authors: Al Mamun Abdullah , Hayat Naeem , Mohiuddin Muhammad , Salameh Anas A. , Zainol Noor Raihani
Published: November 2022

Energy conservation is a necessary form of green behaviour, as energy production and consumption gravely affect the climate. The current study aimed to explore energy conservation behaviour among Chinese households based on the value-belief-norm framework. This study used a cross-sectional design and collected quantitative data from 1671 respondents through an online survey. The hybrid analysis techniques of partial least squares structural equation modelling and artificial neural network analysis were used to analyse the data. Findings revealed that biospheric values have a positive and significant effect on pro-environmental beliefs, awareness of consequences, and ascription of responsibility, which ultimately explains 46.3% of the change in personal norms and 42.6% of the change in green trust. The results shed light on the significant positive impact of green trust and personal norms on the energy conservation intention. Green trust and personal norms can elucidate 27.3% of the change in energy conservation intention. The energy conservation intention (39.1%) explains the energy conservation behaviour. The results of ANN analysis revealed energy conservation intention, personal norms, green trust, and awareness of consequences as the four most significant contributors to the formation of energy conservation behaviour. The current study extended the VNB model with the green trust. It offered empirical evidence on the effects of pro-environmental belief, awareness of consequences, and ascription of responsibility concerning energy conservation intention. Energy policies should thus concentrate on addressing energy conservation behaviour, promoting energy-efficient household appliances, and rewarding energy conservation by lowering energy prices for low-energy users.