bluuebunny/crossref_metadata_2025 huggingface dataset:
Protective effect of arginine glutamate (glutargin) in chronic pancreatitis induced by nitric oxide synthase blocker
Authors: Krylova Olena , Rudenko Anatoliy
Published: July 2024

Introduction. Nitric oxide (NO) is a gaseous molecule that is a biological mediator that carries out important regulation of physiological processes necessary for the functioning of tissues. We hypothesized that nonspecific inhibition of all isoforms of NOs would cause pancreatic damage and created a model of experimental pancreatitis based on NOs inhibition. Along with the study of the mechanisms of development of chronic pancreatitis, the search for medicines to treat and inhibit the progression of this disease continues. Purpose of the research. To study the protective effect of glutargin on the pancreas of rats with chronic pancreatitis induced by a blocker of NOs. Material and methods. The work was carried out on 21 laboratory white male Wistar rats weighing 180-230 g. Chronic pancreatitis was induced by intraperitoneal administration of the NOs blocker - N-nitro-L-arginine (L-NNA) (Sigma-Aldrich, USA) at a dose of 40 mg/kg of body weight. Rats in group I (n = 7) were injected with L-NNA for 12 days, rats in group II (n = 7) were injected intraperitoneally with glutargin 20 mg/kg, after 20 minutes they were injected with L-NNA - within 12 days. Rats of the control group (n = 7) were injected intraperitoneally with 0.9% NaCl solution. The rats were euthanized on the 45th day and biochemical and morphological studies were carried out. Results. After the introduction of the NOs blocker, deterioration of the general condition of the animals was determined, a sharp increase in the level of nitrites/nitrates to 80.22±19.91 μmol/l, control 32.61±4.55 μmol/l (р < 0.05); protein-bound hydroxyproline (PBH) to 215.21±22.01μmol/l, control 178.67±26.39 μmol/l, (p < 0.05); free hydroxyproline (FH) to 14.74±1.84 μmol/l, control 9.96±0.71 μmol/l, (p < 0.05); malondialdehyde (MDA) to 5.67±0.88 nmol/ml, control 3.62±0.13, (р < 0.05). Pronounced structural changes with stasis of formed blood elements in the vessels, focal accumulation of leukocytes in the parenchyma, dystrophy of acinar cells and fibrosis in the atrophy zone were determined in the pancreas of rats. Administration of glutargin contributed to the restoration of general behavioral reactions of rats, normalization of MDA – 4.81±0.15 nmol/ml, control 4.50±0.23, (p > 0.05); ceruloplasmin (CP) – 591.71±68.07 mg/ml, control – 663.25±34.05 mg/ml, (p > 0.05); PBH 183.62±5.98 μmol/l, control – 179.28±9.19 μmol/l, (p > 0.05); FH – 9.44±1.13 μmol/l, control – 9.96±0.71 μmol/l, (p > 0.05) and prevented the development of pronounced structural changes in the pancreas. Conclusions. In chronic pancreatitis induced by a NOs blocker, glutargin can prevent chronic pancreatitis by normalizing collagen metabolism, inhibiting oxidative stress, and severity of pancreatic parenchymal damage.
Knowledge, attitudes, and practices of the population regarding viral Hepatitis B and C worldwide: a systematic literature review
Authors: Călugăreanu Valentin
Published: July 2024

Introduction. The term “hepatitis” implies liver damage by inflammatory cells, a condition with numerous origins. Viruses, predominantly hepatitis B and C viruses cause most cases of hepatitis, which can lead to chronic liver diseases. Assessing the general knowledge and awareness of the population regarding viral hepatitis is crucial for developing targeted and effective strategies to address these epidemics. This knowledge can help tailor interventions for different population strata, such as youth and adults, thereby enhancing the impact of prevention and care efforts. Materials and methods. An exhaustive search of relevant literature was performed in electronic databases such as PubMed, Scopus, and Web of Science. Key terms included “viral hepatitis B,” “viral hepatitis C,” “knowledge,” “attitudes,” “practices,” and “population.” Articles included in the analysis were selected based on predefined inclusion and exclusion criteria. Results. In a Nigerian hospital, 33% of healthcare workers lacked knowledge of hepatitis B, and 35% were not immunized. In an Iraqi study, 75% believed HBV is more easily transmitted than HIV, and 33.9% knew HBV could spread through toothbrushes. In India, most medical students were aware of hepatitis B (84.8%). Their knowledge about transmission through blood transfusion (81.06%) and needles (74.1%) was good, but they had poor knowledge about other modes of transmission and clinical features. A study in Tehsil Wazirabad, Gujranwala found good knowledge about hepatitis C transmission and symptoms. In Saudi Arabia, dental students revealed insufficient knowledge about hepatitis B infection. Practice levels varied, with 47.2% showing high practice and 22% low practice. Female participants exhibited higher knowledge, attitudes, and practices. In Gauteng province, South Africa, a 2015 study found that healthcare workers had inadequate knowledge of viral hepatitis. The average knowledge score was 2.0 out of 6, while practice and attitude scores were higher. Conclusions. A significant difference in knowledge levels regarding viral hepatitis B and C was highlighted within the population. The overall level of knowledge regarding viral hepatitis B and C remains inadequate among both medical personnel and the general population. There is a growing need for education and awareness about viral hepatitis B and C.
A review of type III GEJ adenocarcinoma and the importance of early detection of gastric cancer
Authors: Jadhav Alisha ,   Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA., Ayyat Mumen , M Serafini Francesco ,   Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.,   Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA.
Published: July 2024

Gastric adenocarcinoma is the most common type of gastric cancer in the United States. Multiple factors can predispose a patient to develop such a malignancy, including having a history of Helicobacter pylori infection, tobacco use, alcohol use, specific genetic mutations, and being of Asian or Hispanic descent. Surgery is currently the only curative treatment for localized disease. With metastatic disease, the rate of survival decreases significantly, and most often, the only treatment option is palliative chemotherapy with or without combination radiation therapy. In the case of a 58-year-old man diagnosed with a gastroesophageal junction type III gastric adenocarcinoma that extended into the distal esophagus, what was thought to be a resectable tumor had already invaded vital neighboring organs, therefore, we were unable to eradicate the disease from this patient.
Open conversion for refractory type II endoleaks. Is it the best way?
Authors: Peckham Jon ,   Division of Hematology and Oncology, University of Washington, Seattle, WA, USA, Smith Stephen ,   Division of Hematology and Oncology, University of Washington, Seattle, WA, USA
Published: July 2024

Introduction: Type II endoleaks occur frequently following Endovascular Aortic Repair (EVAR), which, in most cases, does not require any treatment. However, managing persistent endoleaks that enlarge the aneurysm sac can be challenging and may require less invasive measures (endovascular interventions). Open Conversions (OCs) are well described in the literature but are invasive and negate the advantages of EVAR.
Use of Non-Invasive Elastographic and Microvascularization Biomarkers in the Diagnosis and Follow-Up of Children with Severe Bacterial Pneumonia
Authors: Huerta-Calpe Sergi ,   Pediatric Intensive Care Unit, Sant Joan de Déu Hospital, Esplugues de Llobregat, Barcelona, Spain
Published: July 2024

Imaging tests such as Chest X-Ray (CXR) and Lung Ultrasound (LUS), and blood biomarkers like C-reactive protein and procalcitonin have demonstrated its role for Bacterial Pneumonia (BP) diagnosis. However, the implementation of novel biomarkers such as Lung Shear-Wave Elastography (LSWE) or the quantification of lung microvascularization ratio pattern by Superb Microvascular Imaging (SMI) has not yet been assessed. These biomarkers combined with the already described LUS findings, could be used to increase BP diagnosis accuracy, improving the sensitivity and specificity of its diagnosis. In this article, we describe the use of these non-invasive novel imaging biomarkers for the diagnosis approach in a pediatric patient with severe BP.
Technical Efficiency Versus Land-Use Efficiency: A Spatio-Temporal Efficiency Analysis of China’s Crop Production
Authors: Yin Fang , Sun Zhanli , You Liangzhi , Wei Huang Vivian
Published: July 2024

Improved land-use efficiency in agricultural production is crucial to meet increasing demand for agricultural commodities using the finite area of arable land worldwide. By applying a spatial autoregressive stochastic frontier methodology to county-level data spanning from 1980 to 2011, we conducted an analysis to investigate changes in both the spatial and temporal dimensions of technical efficiency and land-use efficiency within Chinese crop production. During this period, China achieved a remarkable upsurge in food production, notably within the first three decades of the rural reform that began in 1978. There were substantial transformations in agricultural land use that encompassed changes in cropland areas, shifts in the composition of various crops, alterations in their geographical distributions and enhancements in crop yields. Based on the results of this analysis, land-use efficiency increased slightly from 0.47 to 0.56 in most regions of China during that period and became convergent over time, with spatial gaps narrowing. National technical efficiency increased by 20 % on average, but with substantial regional variations, e.g. lower technical efficiency gains in northeast and northwest China and greater technical efficiency in the north and south. Urbanisation was found to be positively associated with lower technical efficiency, while a greater distance from provincial capitals resulted in higher technical efficiency. Efficient land use can lead to greater agricultural productivity, which, in turn, can boost rural economies and contribute to overall economic growth. These results could help in the design of effective regional policies to optimise land-use efficiency in crop production.
The effect of healthcare volunteer program on nursing students' nursing professionalism, self-efficacy, self-leadership, major satisfaction and volunteer activity satisfaction
Authors: Jeon Mi Yang , Yu Mi , Jung So Hee , Yoon Chi Yang , Back Won Hee ,   Korea Safety Culture Society
Published: July 2024

Purpose: This study attempted to determine the effects of a healthcare volunteer program on nursing students’ professionalism, self-leadership, self-efficacy, major satisfaction, and volunteer activity satisfaction. Method: This study collected data before and after the implementation of a healthcare volunteer program consisting of 4 hours of education including 3-hour lecture and 1-hour practice, and 70 hours of medical volunteer activities over a period of 2 months from January to February 2024. The subjects who participated in this study were 55 freshmen and sophomore in nursing students. The effectiveness of the program was analyzed using the IBM SPSS WIN program, and the effects of nursing professional intuition, self-leadership, self-efficacy, and major satisfaction were analyzed using paired t-tests, and volunteer activity satisfaction was analyzed using mean and standard deviation. Results: In this study, the experimental group's nursing professionalism increased from 115.35±11.85 points to 122.91±12.46 points (t=3.26, p=.002), and self-leadership increased from 64.27±7.16 points to 66.98±7.41 points (t=2.10, p=.041), self-efficacy increased statistically significantly from 65.69±8.70 points to 69.45±10.45 points (t=2.31, p=.025). However, major satisfaction increased from 24.24±3.75 points to 24.78±4.06 points, but there was no statistically significant difference (t=0.72, p=.472). In this study, volunteer activity satisfaction was 96.90±13.67 points, which when converted to a perfect score of 100, was 86.52 points. Conclusion: The results shows volunteer activities at medical institutions can increase nursing students' professionalism, self-leadership, and self-efficacy before clinical practice. Therefore, we suggest volunteer work at medical institutions to increase nursing students' professional intuition, self-leadership, and self-efficacy.
MATRIX GENERALIZATION OF THE PROBLEM OF 3D COORDINATE TRANSFORMATION
IN SATELLITE CONSTRUCTIONS
Authors: DEGTJAREV A. , DEGTJAREVA E. , VALOSHYNA M.
Published: July 2024

The article considers the problem of generalizing the 3D Helmert transformation by 7 parameters and differential
equations of the 1st and 2nd types of spheroidal geodesy. A formula is obtained in matrix form, which includes, as special
cases, almost all types of coordinate transformations used in satellite geodesy, as well as several new types.
NONLINEAR CALCULATION OF BENT STEEL-REINFORCED CONCRETE ELEMENTS
Authors: LAZOUSKI D. , GLUKHOV D. , KHATKEVICH A. , HIL A. , CHAPARANGANDA E.
Published: July 2024

Steel-reinforced concrete structures at the present stage of development of the construction industry are widely used in industrial buildings with heavy loads on floors, civil high-rise buildings and various engineering structures. The article presents the results of using a nonlinear calculation method to calculate the parameters of the stress-strain state (normal stresses and relative deformations at any stage of work under load, strength and deformability) of bent steel-reinforced concrete elements, provided that rigid steel profiles and reinforced concrete work together.
When calculating the parameters of the stress-strain state of steel-reinforced concrete elements, the stages of their work during manufacture (forced shrinkage deformations of monolithic concrete during its hardening) and operation (creep of concrete under prolonged load action) are taken into account. A criterion for calculating the bending moment corresponding to the strength of a steel-reinforced concrete element is proposed, which does not require normalization of the ultimate compressibility of concrete, allowing for a high degree of redistribution of forces in the cross section of a steel-reinforced concrete element with rigid reinforcement. The advantages of the nonlinear calculation method are demonstrated by examples of steel-reinforced concrete floor beams from TKP 45-5.03-16-2005 "Structures of steel-reinforced concrete coatings and floors. Design rules".
A Pragmatic Analysis of Language As A Mechanism For Peaceful Interaction: A Case Study of When Women Go Naked
Authors: Unoalegie Bolaagbara Clara
Published: July 2024

Most parts of the world today are enveloped in conflict caused by personal ambitions, selfishness, economic disasters, religious beliefs, gender discrimination, ideologies, unequal distribution of natural resources, and many more daunting causes. The effect of these conflicts has led to several losses of lives and properties, stunted socio- economic growth and development. The question is what can be done so that the world enjoys living that is more peaceful and less conflict prone. The popular adage ‘the pen is mightier than the sword’ provides the solution. Pen symbolises the appropriate choice of linguistic codes to communicate messages. Language is not simple an instrument of messaging but also a device for the expression of an individual’s thought and feelings; a reflection of a speaker’s inner sensitivity and mood. This study, using the play When Women Dance Naked as data, sets out to examine the language used during conflict situation and its effect on the relationship between interlocutors. The study, using multifaceted approaches, reveals that when speakers resort to the use of positive words that respect the addressee’s self-esteem, peace is developed and maintained. While the use of negative and downgrading codes fuel hatred and accelerate conflicts. The study concludes that appropriate choice of linguistic codes is essential in order to building, development and maintenance peace. Language can be used not only as a weapon of reconciliation where there is disharmony or conflict but also as an implement to create and deescalate conflict which can wipe out an entire family or society.
《孝經皇帝感》所見唐玄宗《御注孝經》的傳播與接受形式
Authors: 姚魯元 姚魯元
Published: July 2024

唐玄宗（685-762, 712-756在位）曾兩次頒《御注孝經》，欲統一諸家舊注，敦煌本《孝經皇帝感》即《御注》的民間衍生文本，其通俗的表述、名實不符的文本來源，與官方正典截然有別。本文以《御注》兩種文本為例，考察其在民間的傳播與接受形式，探討皇帝權力的下行及邊界。從文本內容來看，《御注》以注疏闡發玄宗「君臣同體」的微言大義，具有君臣關係一元化的特質。《孝經皇帝感》卻是以《御注》讚歌與地方流行的鄭玄舊注拼接而成，皇帝意志受限庶民認知能力而被篩除。從文本產生、傳播的過程來看，五代敦煌仍然延用鄭注，《御注》寥寥無幾，民間歌場效仿《御注金剛經讚詞》創作的《孝經皇帝感》卻頗為流行，反哺了玄宗頒行《御注》於天下的意圖。這種文本雖然剝離御注經典的原生意義，但潛在地成為皇帝的象徵符號，成功傳達其權威。

 

During the reign of Tang Xuanzong (685-762, r. 712-756), the Yuzhu Xiaojing was issued twice to try to unify older annotations. The Xiaojing huangdi gan found in the Dunhuang manuscripts is a folk derivative text of the Yuzhu Xiaojing. Its popular style and the unorthodox source of the text are completely different from the canon promulgated by the imperial court. This article focuses on the two forms of the Yuzhu Xiaojing to discuss the spread and acceptance of the emperor’s authority among the people. On the one hand, judging from the content of the two texts, Yuzhu Xiaojing conveys Xuanzong’s interpretation of the “subtle meaning” of the classic: that “the monarch and his subjects are the same.” Its annotations serve to unify the ideological relationship between the monarch and his subjects. However, Xiaojing huangdi gan is a combination of the summary verses of the Yuzhu Xiaojing and the traditional annotations of Zheng Xuan, which had remained popular at the local level. On the other hand, from the point of view of the text generation and dissemination process, in Five Dynasties Dunhuang, Zheng’s annotations remained in use, and there were very few copies of the Yuzhu Xiaojing. Instead, the Xiaojing huangdi gan, which was spontaneously created in folk music venues in imitation of the Summary Verses of the Diamond Sutra, was quite popular. Thus, the emperor’s intentions were fulfilled in an indirect way. Although this text completely away stripped the original meaning of the Yuzhu Xiaojing, it successfully became an imperial symbol, conveying the emperor’s authority.

 
從護學到衛國—— 南宋的太學祠祀信仰
Authors: 林君憲 林君憲
Published: July 2024

宋代祠祀信仰相當興盛，在為國家培養德才兼備之儲備人才的南宋太學之內亦存在被奉祀的祠神，根據《宋史》記載可知該神為岳飛。然而，經過考察相關記載之後，本文發現太學祠祀信仰，實際上經歷了從祭祀土地神到後來以岳飛為廟神的變化，出現此變化的原因，與太學生群體意識的高漲，以及朝廷有意旌忠的統治手段有關。最後，本文也針對太學祠祀信仰的內涵展開討論，指出雖然隨著岳飛擔任廟神的說法影響日深，「旌忠」成為該信仰的主流價值，然而原有的「靈驗」特質非但沒有消失，反而與之結合，生動的展示出信仰發展過程所具有的動態性。

 

Folk beliefs flourished during the Song Dynasty, and even the highest educational institution, the taixue (National University), had a deity that was worshipped. According to the History of the Song Dynasty, the god worshipped in the Southern Song taixue was Yue Fei. However, after examining the relevant records, this paper finds that the folk beliefs of the Taixue actually underwent a change from the worship of the land god (tudi shen) to the later use of Yue Fei as the god of the temple. The reasons for this change are related to the rising awareness of the student body at the taixue and the national policy of praising loyalty (jing zhong 旌忠). The article also discusses the implications of this belief, pointing out that although the belief in Yue Fei as the temple deity was becoming more and more accepted, and although “praising loyalty” had become the mainstream value of the belief, the original “efficacious” quality of the god did not disappear, but rather combined with it, vividly demonstrating the dynamic nature of the development process of the belief.

 
Effect of Integrated nutrient management on yield and economics of Maize (Zea mays L.) under grid region
Authors: Sharma Rajul , Singh Abhinandan , Rajput Pradeep , Kanaujiya Pradeep Kumar , Malik Aakash , Gaur Ankur
Published: July 2024

The Field study was carried out during kharif season of 2022 to evaluate the response of maize varieties to INM maize under the subtropical condition of Madhya Pradesh. The experiment was laid out in Factorial Randomized Block Design with two levels (varieties and fertilizers) with total number of twelve treatments combination at Crop Research Centre, School of Agriculture, ITM University Gwalior (M.P.). The maize varieties are; Sujata, RMH1899 and Adv 759and fertilizer Control; 100% RDF, 75% RDF+25% FYM and 75%RDF +25% FYM+ZNSO4 . The result revealed that maximum Yield attributes and yield, Cob length, Number of cobs plant-1, No. of grains per cob, Grain yield (kgha-1), Stover Yield and Biological Yield, relative economics was recorded that the treatment combination of 75% RDF+ 25% FYM + ZnSO4 ha-1 with the V3 variety has given significant higher result on yield and economic on maize.
Correlation and Path Analysis in Cut Chrysanthemum (Dendranthema grandiflora Tzvelev.) Genotypes
Authors: Shivani V. S. , Nataraj S. K. , V. Srinivasa  , S. Sridhara  , Satish K. M. , Yashaswini M. P. , Shastri Yoshita Shrikrishna
Published: July 2024

The study was conducted during the year 2022-23 at ICAR-ELP polyhouse, Department of Floriculture and Landscape Architecture, College of Horticulture, Mudigere to study the correlation and path analysis among twenty cut chrysanthemum genotypes. The Correlation studies revealed the number of flower stems per m2 had highly significant positive correlation with plant spread (N-S), leaf length, leaf width, leaf area, flower diameter and plant spread (E-W) and days taken for bud initiation had significant positive correlation. Path analysis showed number of flower stems per m2 indicated maximum positive direct effect of flower diameter followed by plant spread (N-S), leaf width, vase life, leaf area, number of leaves per plant, days for bud initiation, plant height which indicated the possibility of increasing flower yield by selecting these characters directly.
Monitoring of Heavy Metal and Pharmaceutical Effluents in Ground water of an Industrial Area, Haridwar, Uttarakhand, India
Authors: Gangopadhyay Monica , Naithani Suman , Naithani Pratibha , Jain Chakresh Kumar
Published: July 2024

The purpose of this study is to evaluate the levels of specific heavy metals and pharmaceutical effluents in drinking water in the SIIDCUL region. 40 water samples were gathered for geochemical analysis from various locations. ICP-MS was used to analyze the heavy metals and LC-MS was used for detection of pharmaceuticals. The elements that were examined were Fe, Mn, Zn, Pb and Cd in 47.5%, 7.5%, 2.5%, 0% and 0% of the water samples, respectively, the values of Fe and Zn for a portion of the groundwater samples were higher than the suggested standard. In pharmaceuticals, antibiotics were examined in drinking water samples. For all three population classes, the Hazard Index due to ingested heavy metals do not exceeds the permissible range.
Analyzing the Impact of Political Space on Democratic Quality in Uzbekistan: An Econometric Assessment Using the V-Dem Database
Authors: Papaoikonomou Anthony
Published: July 2024

In this study a multiple regression model is presented analyzing the impact of political space on democratic quality in Uzbekistan. The Varieties of Democracy (V-Dem) database is used. It is focused on the indices of political violence, freedom of peaceful assembly and polarized society. The main hypothesis of this study is that due to political reformations after the collapse of Soviet Union, major changes have been achieved in Uzbek society and its political system, a fact that has created new challenges for the future. It seems that there is a shift towards liberalization in Uzbekistan, a fact that denotes the implementation of reforms directed towards fostering political, economic, and social openness within the country.
Tiroides y envejecimiento
Authors: Fuentes Trespalacios Rubén Hernando de Jesús , Suarez Guerrero Jorge Luis
Published: July 2024

Contexto: el envejecimiento trae consigo cambios fisiológicos y patológicos en diferentes órganos y sistemas, sin ser una excepción la tiroides.
Objetivo: realizar una revisión narrativa sobre patología tiroidea en el adulto mayor.
Metodología: se llevaron a cabo revisiones en bases de datos (Pubmed, Scielo), abarcando principalmente los últimos 15 años, con palabras clave como enfermedad de Graves, envejecimiento, vejez, hipotiroidismo e hipertiroidismo.
Resultados: la función tiroidea presenta cambios en el envejecimiento, propios de la fisiología, no obstante, en patología subclínica o francamente establecida, las manifestaciones clínicas del adulto mayor pueden variar respecto a otros grupos de edad.
Conclusiones: en el adulto mayor, resulta importante conocer los cambios fisiológicos y patológicos, siendo un reto diagnóstico, de ahí la importancia de identificarlos, tanto en hipotiroidismo como en hipertiroidismo, para realizar un correcto abordaje en este grupo poblacional. Es por ello que se presenta información relevante y puntos clave para el mejor abordaje de estos pacientes.
From the Editor's Desk: Immediate Concerns
Authors: Fookes Ian
Published: July 2024

Welcome to the ninth special issue of Ekistics and the New Habitat: The problems and science of human settlements. On behalf of the Executive Board, I would like to briefly introduce the present special issue: Ekistics-Related Research in Greece (Part 3 of 3): Planning Strategies / Policies and Politics.
Integrative Analysis Identified rs907091 at the miRNA Binding Region of the IKZF3 Gene as a Potential Functional Variant for Rheumatoid Arthritis
Authors: Xia Wei , Wu Longfei , Lei Shufeng
Published: July 2024

Objective: Previous studies have identified a large number of associations between genetic variants and rheumatoid arthritis (RA), but the functional mechanisms underlying the associations are largely unknown. Methods: Based on publicly available datasets and results, we explored the functional mechanisms underlying the associations between regulatory polymorphisms in miRNA target sites (poly-miRTSs) and RA by combining integrative analyses (expression quantitative trait locus analysis, eQTL, and gene enrichment analysis) with in-house molecular experiments (allelic expression imbalance experiment, AEI, and dual-luciferase reporter gene assay). Results: By integrating the results from the MirSNP and eQTL databases, a total of 114 pairs between poly-miRTSs and target genes were identified, which correspond to 70 unique poly-miRTSs and 28 genes. Most of the 28 genes were located in the HLA region, and they tended to be enriched in multiple immune-related GO terms or pathways, e.g., “antigen processing and presentation” and “immune response”. Among these poly-miRTSs, rs907091 in the 3’UTR of IKZF3 (non-HLA region) was highlighted. Further AEI experiments showed that the C allele had a higher expression of ~18% than the T allele, suggesting an obvious allelic expression imbalance. Dual-luciferase reporter gene assays showed that miR-326 and miR-330-5p could regulate IKZF3 expression (P<0.05) mediated by rs907091 in the 3’UTR binding site. Conclusion: Our study explored some functional mechanisms underlying the associations between poly-miRTSs and target genes and highlighted rs907091 at the miRNA binding region of the IKZF3 gene as a potential functional variant for rheumatoid arthritis.
Atitudes e consumo sustentáveis de discentes de uma Universidade Estadual do Paraná
Authors: Brene Paulo Rogério Alves , Castorini Luccas Damasceno da Cunha , Vilela Nathalia , Bronzeri Marcia Souza , Poletto Rodrigo de Souza , Bernardes Victor Ângelo Primo
Published: July 2024

A sustentabilidade tem se tornado um tema de grande relevância devido ao impacto que causa no desenvolvimento da humanidade, por isso, vem sendo abordada cada vez mais dentro das instituições de ensino, porém mesmo assim, pouco se sabe sobre o impacto de tal conhecimento sobre as atitudes e consumo sustentáveis dos discentes de uma Universidade. Diante de tal problemática o objetivo desse artigo é avaliar as atitudes e consumo sustentáveis dos estudantes do curso de Administração de uma Universidade Estadual, no Paraná. Para isso foi aplicado um questionário de forma on-line, com acompanhamento dos pesquisadores, o que resultou em 200 participações, do primeiro ao quarto ano da graduação. Ao realizar uma pesquisa quantitativa (survey), observou-se que apesar da educação ter papel fundamental na vida do ser humano, apenas o fato de estar em um curso superior não gera grandes impactos na formação de indivíduos com atitudes e consumo sustentáveis.
Colliding neutron stars: what do gravitational waves and electromagnetic flashes tell us about physics at the extremes?
Authors: Rosswog Stephan
Published: July 2024

Colliding neutron stars: what do gravitational waves and electromagnetic flashes tell us about physics at the extremes?

Mergers of two neutron stars are related to many timely astrophysical questions, such as the production of gravitational waves, the densest forms of matter in the Universe and the cosmic origin of heavy elements. This project applies a novel computational methodology to strive for consistent numerical modelling involving a broad range of both physical processes and length/time scales.
A radical breach with Aristotle
Authors: Wansing Heinrich
Published: July 2024

A radical breach with Aristotle

ConLog investigates non-trivial logical systems in which certain contradictions are provable. The aim is to develop a clear comprehension of the contradictoriness of these logics and to study the consequences of this understanding within the philosophy of logic. Thereby, the project will yield a paradigm shift in our conception of what a respectable logical system and an acceptable scientific theory is.
Fungal wars: tracing single-cell scale chemical signalling between interacting soil fungi
Authors: Pucetaite Milda
Published: July 2024

Fungal wars: tracing single-cell scale chemical signalling between interacting soil fungi

INTERSPEC is dedicated to developing a Raman spectroscopy-based approach for tracing chemical signalling between interacting soil fungal cells to answer important questions within fungal ecology: what determines whether fungi are neutral, antagonistic or facilitative towards each other? What are their ‘warfare strategies’? How do the interactions affect the decomposition of organic matter in soils and, subsequently, carbon cycling?
The power of words
Authors: Pulvermüller Friedemann , Dobler Fynn , Henningsen-Schomers Malte
Published: July 2024

The power of words

Compared to our closest living relatives, who typically use fewer than 100 words, humans can build vocabularies of tens of hundreds of thousands of words. The ERC- funded Advanced Grant project ‘Material Constraints enabling Human Cognition’, or ‘MatCo’, will find out why. It will use novel insights from human neurobiology. These will be translated into mathematically exact computational models to find new answers to long-standing questions in cognitive science, linguistics and philosophy. The project will also explore how semantic meaning is implemented for gestures and words and, more specifically, for referential and categorical terms. To identify human cognitive capacities, MatCo will develop models replicating structural differences between human and non-human primate brains. The results will shed light on the biologically constrained networks.
Deep Spectral Convolution Neural Network Based Leukemia Cancer Detection Using Invariant Entity Scalar Feature Selection
Authors: B. B. ,   Research scholar, Department of Electronics Communication,   Associate professor, Department of Biomedical Engineering, Faculty of Engineering, Karpagam Academy of Higher Education, Coimbatore, Mohanarathinam A.
Published: July 2024

Leukemia, a cancer that attacks human white blood cells, is one of the deadliest illnesses. Detecting affected cells in microscopic images becomes tedious because feature variants are not predicted correctly by a hematologist. Therefore image handling techniques failed to select the importance of the features scaling counts, entities, and precise size and shape of cells presented in the microscopic image. To resolve this problem, Deep Spectral Convolution Neural Network (DSCNN) based on Leukemia cancer detection using Invariant Entity Scalar Feature Selection (IESFS) is proposed to identify the risk factor of cancer for early diagnosis. Initially, preprocessing is carried out using cascade Gabor filters. Based on Structural Cascade Segmentation (SCS), the white blood cell regions are categorized into affected and non-affected margins and verify the edges using canny edge mapping. This estimates the scaling cell size, counts, entities and angular cell projection of weights from each segmented feature region. Then find the entity relation of cell projection equivalence using Color Intensive Histogram Equalization (CIHE). After segmenting the angular vector, projection scaling is applied to correlate the entity's object scaling comparator. Then scaling features were selected using Invariant Entity Scalar Feature Selection (IESFS) by averaging the mean depth values of feature weight and trained with a deep convolution neural network for predicting max equivalence entity weights for finding the affected cells and counts in microscopic images. This improves the prediction of cancer cell accuracy as well high performance in sensitivity 92.7 %, specificity 92.3 %, and f-measure 93.6 % with redundant time complexity.
Modelling a Request and Response-Based Cryptographic Model For Executing Data Deduplication in the Cloud
Authors: Nulaka Nulaka ,   Computer Science and Engineering, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India,   Computer Science and Engineering, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India, Srinivasu Nulaka
Published: July 2024

Cloud storage is one of the most crucial components of cloud computing because it makes it simpler for users to share and manage their data on the cloud with authorized users. Secure deduplication has attracted much attention in cloud storage because it may remove redundancy from encrypted data to save storage space and communication overhead. Many current safe deduplication systems usually focus on accomplishing the following characteristics regarding security and privacy: Access control, tag consistency, data privacy and defence against various attacks. But as far as we know, none can simultaneously fulfil all four conditions. In this research, we offer a safe deduplication method that is effective and provides user-defined access control to address this flaw. Because it only allows the cloud service provider to grant data access on behalf of data owners, our proposed solution (Request-response-based Elliptic Curve Cryptography) may effectively delete duplicates without compromising the security and privacy of cloud users. A thorough security investigation reveals that our approved safe deduplication solution successfully thwarts brute-force attacks while dependably maintaining tag consistency and data confidentiality. Comprehensive simulations show that our solution surpasses the evaluation in computing, communication, storage overheads, and deduplication efficiency.
ANALISIS PENGARUH KEMAMPUAN DAN MOTIVASI TERHADAP KINERJA STAF DALAM MENDUKUNG TUGAS POKOK DI KODAM JAYA TNI AD
Authors: Nuraeni Irine , Ahmad Asep
Published: July 2024

Pada penelitian ini mengungkap dan menganalisis pengaruh dari kemampuan dan motivasi personel terhadap kinerja yang ditunjukkan oleh personel Kodam Jaya TNI AD. Teori dan konsep yang digunakan dalam penelitian ini di antaranya adalah Teori Kemampuan, Teori Motivasi, Teori Kinerja, dan Konsep Manajemen Sumber Daya Manusia. Metode yang digunakan dalam penelitian ini adalah metode penelitian kuantitatif dengan teknik pengumpulan data menggunakan kuesioner. Uji coba instrumen menggunakan uji validitas dan uji reliabilitas. Dianalisis menggunakan uji asumsi klasik. Jumlah sampel dari penelitian sebesar 390 responden. Hasil penelitian menunjukkan bahwa seluruh item pernyataan dinyatakan valid dan reliabel dan berdasarkan hasil pengolahan data secara simultan diatas diperoleh hasil yang menyimpulkan bahwa  kemampuan kerja  dan motivasi kerja berpengaruh positif dan signifikan terhadap kinerja di Kodim Jaya/ Jakarta. Hal ini bermakna jika terdapat peningkatan pada kemampuan yang dimiliki personil, personil merasa termotivasi untuk bekerja dan meningkatnya disiplin kerja personil maka kinerja personil juga akan turut meningkat.
Prevalence of Inflammatory Back Pain (IBP) In Patients with Backache Visiting Rheumatology OPD at Khyber Teaching Hospital, Peshawar
Authors: Ali Amjad , Najibullah . , Zeb Alam , Imranullah . , Khan Inamullah
Published: July 2024

Back pain is a prevalent and often paralyzing condition that impacts people of all ages and backgrounds. When it comes to back pain, it is crucial to differentiate between different kinds in order to accurately diagnose and effectively treat the problem. Objective: To ascertain the frequency of Inflammatory Back Pain (IBP) in patients presenting with low back pain. Methods: This descriptive study was conducted in rheumatology department of Khyber Teaching Hospital, Peshawar, during the period 1st September 2023 till 31st March 2024. Male and female patients with back ache (VAS >4) were enrolled and evaluated for the presence of inflammatory back pain using ASAS criteria. Results: The study included 138 patients, 60 (43.48%) male and 78 (56.52%) female. Mean age was 51.7 ± 5.8 years. Majority of the patients belonged to the age group 46 to 60 years 45 (32.60%). The ASAS criteria for IBP was satisfied by 54 (39.1%) patients. Statistically significant association was observed between IBP and family history of IBP. Conclusions: Significant proportion of patients with back pain were found having pain with inflammatory etiology. Male patients aging 46 to 60 years with family history of IBP were more likely having IBP
Challenges and Strategies in Addressing Cultural Stereotypes and Bias in Indonesian Tertiary ELT/EFL Classrooms
Authors: Nabung Adrianus
Published: July 2024

This study explores the complexities surrounding cultural stereotypes and bias within the Indonesian tertiary English Language Teaching/English as a Foreign Language (ELT/EFL) classrooms. Recognizing culture as a dynamic amalgamation of beliefs, values, and practices, it underscores its pivotal role in language acquisition. Employing a descriptive qualitative approach, the research utilizes semi-structured questionnaires and in-depth interviews to capture educators’ and students’ lived experiences, perceptions, and attitudes. The findings illuminate a shared acknowledgment of the significance of divulging personal information to counter cultural stereotypes, albeit with divergent viewpoints. Despite encountering obstacles, participants have tangible awareness regarding cultural biases within the educational setting, with the integration of diverse materials emerging as a perceived effective strategy. The study underscores the acknowledged difficulty in tackling cultural stereotypes but underscores the confidence in educators’ abilities to actively implement strategies. Moreover, teacher responsiveness to student feedback on cultural inclusivity is viewed as constructive. It duly recognizes the impact of cultural stereotypes on the learning environment and advocates for inclusive and culturally sensitive educational approaches. In conclusion, the research advocates for proactive measures to address cultural biases, promoting inclusivity and sensitivity within Indonesian tertiary ELT/EFL classrooms.
Comprehensive Risk Assessment of Farmer Households in Flood and Earthquake Prone Areas Based on Multidimensional Information Diffusion Model
Authors: Pan Xiao-jun , Zhang Xi , Li Pei-huan , Pu Cheng-yi
Published: July 2024

In recent years, the global practice of regional natural disaster reduction and comprehensive risk prevention has promoted the integration of multiple disciplines, and the theory and technology of comprehensive risk assessment for multiple natural disaster chains urgently need innovation. This article is based on multiple natural disaster chain scenarios and sets secondary indicators for multiple influencing factors based on the first level indicators composed of basic risk factors such as hazard factors, vulnerability of disaster bearing bodies, and disaster prevention and reduction capabilities. By using multidimensional information diffusion technology, multiple hazard factor hazard combination factors, vulnerability combination factors of disaster bearing bodies, and comprehensive disaster prevention and reduction capability combination factors reflecting various natural disaster scenarios are constructed, A household comprehensive risk assessment index system for multi-dimensional information diffusion assessment of natural disaster comprehensive risk was designed by quantifying risk factors such as the intensity of comprehensive disaster causing factors, vulnerability of disaster bearing bodies, and comprehensive disaster prevention and reduction capabilities in disaster scenarios. This paper expands the traditional information diffusion comprehensive risk assessment model, makes up for the lack of information on geographical units, establishes a multi impact factor multi dimension natural disaster risk comprehensive assessment model for multi risk factors of complex disaster scenarios with small samples, obtains the theoretical value of multi-dimensional information Diffusion model comprehensive risk assessment for complex disaster scenarios, breaks through the sample size limit of natural disaster risks, and makes up for the lack of information on small samples of small probability events, Improved the reliability and accuracy of comprehensive risk assessment for multiple natural disaster chains. Then, take the disaster scenario formed by the comprehensive risk of earthquake and flood in a place in the upper reaches of the Fujiang River basin as the analysis sample, calculate the comprehensive risk assessment value of flood and earthquake damage in the study area's micro samples (rural households in villages and towns). By comparison, it is found that the comprehensive risk value assessed by the multi-dimensional information Diffusion model has good reliability and high accuracy, which is significantly better than the traditional Kriging interpolation method and geographical weighted regression method. This article provides a comprehensive risk assessment of natural disasters at the micro household level, which can better reflect the diversity and regionality of risks, help clarify the hidden risks of rural natural disasters, and provide scientific basis for government emergency management decision-making.
Computer Calculation Program for Heating the Cylinder at a Constant Surface Temperature of the Charge
Authors: Boryca Jarosław ,   Department of Production Management, Faculty of Production Engineering and Materials Technology, Czestochowa University of Technology, 42-201
Published: July 2024

As part of the work, on the basis of analytical relationships, a computer program was developed, which was used to calculate the heating process of a cylindrical charge. Calculations were made for heating at a constant temperature of the charge surface. Changes in the temperature of the charge axis, furnace temperature and unit heat flow during heating were also determined.
INDIA’S CYBER LANDSCAPE: AN ASSESSMENT OFINDIAN EFFORTS SINCE INDEPENDENCE
Authors: Ashraf Nageen
Published: July 2024

India, as the world's largest digitally connected democracy, recognizes the critical importance of cyberspace in the face of evolving technological dynamics. With the second-largest global internet base, India emphasizes self-sufficiency to bolster cyber resilience and reduce dependence on foreign technology. This research explores India's historical efforts, spanning from the post-independence era to contemporary times, aimed at fortifying its cyberspace. The study delves into domestic measures such as the New Electronics Policy (NEP), IT Act 2000, and the National Cyber Security Policy, complemented by the establishment of key entities like the National Informatics Centre, CERT-In, Defence Cyber Agency, and National Task Force. The analysis extends to bilateral and multilateral collaborations, elucidating India's position as a global IT industry leader. Secondary resources of data, along with the Primary documents-including India's official policies-form the basis of this research, offering a comprehensive understanding of India's digital landscape.
1963- 1977 Yılları Arasında Türkiye Cumhuriyeti'nin Uyguladığı Ekonomik Kalkınma Politikalarının Uzun Dönem Makroiktisadi Verileriyle Karşılaştırması
Authors: Börü Mustafa Kerem , Daşdemir Esat
Published: July 2024

Bu çalışmanın amacı 1963-1977 yılları arasında uygulanan maliye politikalarının Türkiye ekonomisine etkilerini incelemektir. Kendine özgü yapısı nedeniyle Türkiye ekonomisinde önemli bir geçiş dönemi olan bu dönemin güncellenen literatürle yeniden incelenmesi günümüz Türkiye ekonomisinin anlaşılırlığını kolaylaştırabilecektir. Türkiye ekonomisinin önemli kilometre taşlarından biri olan bu döneme ait önemli makroiktisadi veriler uzun dönem ortalama değerleriyle karşılaştırılmıştır. Ulaşılan sonuçlara göre 1963-77 döneminin tümüyle başarısız ya da başarılı olduğu iddia edilememektedir. Bu dönemdeki bazı makroiktisadi göstergeler ortalamadan başarılı performans sergilemiş olsa da bazılarından göstergelerde beklenilen performans düzeyine ulaşılamadığı gibi bu göstergelerde olumsuz sonuçlar ortaya çıkmıştır. Bu dönemde toplam hasılada ve kişi başına hasılada Türkiye ekonomisinin uzun dönem verilerine göre ortalamanın üzerinde ve istikrarlı bir büyüme olmuştur ve yatırımlar ortalama üzerinde artmıştır. Türkiye ekonomisinin sanayileşme hedefine yönelik performansı bu dönemde ortalamanın üzerindedir. Ancak dönemin en önemli sorunlarından biri olan dış ticaret sorunu çözümlenememiş, dış ticaret açıklarının hasılaya oranı ortalamanın üzerinde gerçekleşmiştir. Bu çalışma kapsamında yapılan karşılaştırma göstermektedir ki, 1963-1977 dönemi genel anlamda başarılı sayılabilse de önemli konularda başarısızlıkları da barındırmaktadır.
ATENÇÃO DOMICILIAR E CRIANÇAS COM CONDIÇÕES CRÔNICAS COMPLEXAS: A IMPORTÂNCIA DO TRABALHO INTERDISCIPLINAR
Authors: Gomes Gabriel Deveza , Santos Bárbara Figueiredo , Souza Katia Maria Oliveira de , Conceição Daniele Santos da
Published: July 2024

Este artigo pretende trazer reflexões sobre a importância do trabalho interdisciplinar no cuidado às crianças com condições crônicas complexas no campo da Atenção Domiciliar. Estas condições são definidas como qualquer condição médica que possa durar no mínimo 12 meses (a menos que a morte intervenha antes disso) e que envolva vários sistemas de órgãos diferentes ou um sistema de órgãos severamente, o suficiente para exigir cuidados pediátricos especializados. Hoje, devido aos avanços nos cuidados de saúde, a prevalência dessas condições tem aumentado na faixa etária pediátrica e, portanto, é necessário pensar em uma linha de cuidado pautada na integralidade, bem como, no que se entende como clínica ampliada - no que se traduz no conjunto de disciplinas que dialogam de maneira horizontal para um objetivo único. Um exemplo deste cuidado que vem se tornando mais frequente é a atenção domiciliar, realizada, em geral, por equipes interdisciplinares. Por meio da revisão de literatura foi possível observar a produção científica de algumas categorias profissionais, reforçando, portanto, a relevância da interdisciplinaridade para o cuidado de crianças com condições crônicas complexas atendidas por programas de Atenção Domiciliar.