bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Intercropping and Bio-Fertilizer Application on the Nutrient Uptake and Productivity of Mung Bean and Marjoram
Authors: Mohammadzadeh Vahid , Rezaei-Chiyaneh Esmaeil , Mahdavikia Hassan , Rahimi Amir , Gheshlaghi Mohammad , Battaglia Martin Leonardo , Harrison Matthew Tom
Published: October 2022

The adoption of eco-friendly fertilizers is increasingly perceived as a sustainable avenue for improving the quantity and quality of medicinal and aromatic plants. Here, we investigated how intercropping and bio-fertilizer application impacted the productivity and essential oil quality of mung bean and marjoram. Treatments were conducted using mung bean monocropping (MBm) and marjoram monocropping (Om), as well as additive intercropping ratios (100% marjoram + 15% mung bean (O/15MB), 100% marjoram + 30% mung bean (O/30MB), 100% marjoram + 45% mung bean (O/45MB), 100% marjoram + 60% mung bean (O/60MB)), each with/without application of biofertilizers (mycorrhiza fungi and bacteria fertilizer). We found that N, P and K content in marjoram and mung bean was highest in the intercropped O/30MB and O/45MB. The maximum land equivalent ratio (LER) index (1.6) was recorded for the O/15MB treatment following biofertilizer application, indicating that 59% more area in the monocropping treatment would be required to achieve the same yield as for the intercropping treatments. The maximum content of carvacrol, p-cymene and carvacrol methyl ether was obtained for the O/45MB treatment under biofertilizer. These results indicate that intercropping of marjoram/mung bean (especially O/45MB) along with biofertilizer application may pave the way towards more sustainable agronomy for improving essential oil quantity and quality.
Spatial–Temporal Evolution Characteristics of Landscape Ecological Risk in the Agro-Pastoral Region in Western China: A Case Study of Ningxia Hui Autonomous Region
Authors: Liu Hao , Hao Haiguang , Sun Lihui , Zhou Tingting
Published: October 2022

Landscape ecological risk assessment can reflect the impact of landscape pattern on ecological processes and functions, and has become an important method for predicting and measuring the quality and dynamic evolution of the ecological environment. Studying the trend of landscape ecological risk evolution is important for optimizing the regional landscape pattern and maintaining the sustainable development of the ecological environment in ecologically fragile areas. Ningxia Hui Autonomous Region is a typical agro-pastoral region in northern China, which is facing prominent ecological and environmental problems such as soil erosion and land desertification. With the environmental problems becoming more and more serious, the ecological risk also poses increasing potential danger, which becomes one of the bottlenecks restricting regional economic development. This paper selects Ningxia Hui Autonomous Region as the study area. Based on land use data in 2000, 2005, 2010, and 2015, the landscape ecological risk assessment model is built from the perspective of landscape ecology, and combines the spatial statistical analysis method and the gravity shift model to explore the spatial–temporal evolution of the spatial distribution characteristics of landscape ecological risk. The results showed that: (1) During the study period, the area of farmland and grasslands has decreased, and the area of forest, water, and settlement has increased; (2) The transformation of land-use types is mainly distributed in the central northern plain and the south valley, where human activities are intensive. The transfer relationship among different land-use types is mainly between grasslands and farmland; (3) The hotspots and aggregation area of landscape ecological risk are mainly distributed along the city belt and irrigated agricultural areas along the Yellow River in the northern Ningxia Plain; (4) From 2000 to 2005, the landscape ecological risk level decreased, and from 2005 to 2015, the landscape ecological risk index continued to rise. We conclude that the natural environment of Ningxia determines the characteristics of the spatial distribution of landscape ecological risk, while the use and modification of land through human activities are the main driving factors of landscape ecological risk change. The results of landscape ecological risk assessment at different scales based on the landscape index will provide support for regional environmental management.
Genetic Aspects of Micronutrients Important for Inflammatory Bowel Disease
Authors: Dragasevic Sanja , Stankovic Biljana , Kotur Nikola , Milutinovic Aleksandra Sokic , Milovanovic Tamara , Stojkovic Lalosevic Milica , Stojanovic Maja , Pavlovic Sonja , Popovic Dragan
Published: October 2022

Inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) are complex diseases whose etiology is associated with genetic and environmental risk factors, among which are diet and gut microbiota. To date, IBD is an incurable disease and the main goal of its treatment is to reduce symptoms, prevent complications, and improve nutritional status and the quality of life. Patients with IBD usually suffer from nutritional deficiency with imbalances of specific micronutrient levels that contribute to the further deterioration of the disease. Therefore, along with medications usually used for IBD treatment, therapeutic strategies also include the supplementation of micronutrients such as vitamin D, folic acid, iron, and zinc. Micronutrient supplementation tailored according to individual needs could help patients to maintain overall health, avoid the triggering of symptoms, and support remission. The identification of individuals’ genotypes associated with the absorption, transport and metabolism of micronutrients can modify future clinical practice in IBD and enable individualized treatment. This review discusses the personalized approach with respect to genetics related to micronutrients commonly used in inflammatory bowel disease treatment.
Reply to Crimi, C.; Cortegiani, A. Comment on “Liu et al. Application of High-Flow Nasal Cannula in COVID-19: A Narrative Review. Life 2022, 12, 1419”
Authors: Liu Cheng-Wei , Cheng Shih-Lung
Published: October 2022

Thanks for Crimi et al.’s comment [...]
Optoacoustic Imaging Offers New Insights into In Vivo Human Skin Vascular Physiology
Authors: Monteiro Rodrigues Luis , Granja Tiago F. , de Andrade Sergio Faloni
Published: October 2022

Functional imaging with new photoacoustic tomography (PAT) offers improved spatial and temporal resolution quality in in vivo human skin vascular assessments. In the present study, we followed a suprasystolic reactive hyperemia (RH) maneuver with a multi-spectral optoacoustic tomography (MSOT) system. A convenience sample of ten participants, both sexes, mean age of 35.8 ± 13.3 years old, was selected. All procedures were in accordance with the principles of good clinical practice and approved by the institutional ethics committee. Images were obtained at baseline (resting), during occlusion, and immediately after pressure release. Observations of the RH by PAT identified superficial and deeper vascular structures parallel to the skin surface as part of the human skin vascular plexus. Furthermore, PAT revealed that the suprasystolic occlusion impacts both plexus differently, practically obliterating the superficial smaller vessels and evoking stasis at the deeper, larger structures in real-time (live) conditions. This dual effect of RH on the skin plexus has not been explored and is not considered in clinical settings. Thus, RH seems to represent much more than the local microvascular reperfusion as typically described, and PAT offers a vast potential for vascular clinical and preclinical research.
Study of the Contact Characteristics of Machine Tool Spindle Bearings under Strong Asymmetric Loads and High-Temperature Lubrication Oil
Authors: Dong Yanfang , Chen Feifan , Qiu Ming , Wang Huijie , Yang Chuanmeng
Published: October 2022

The contact characteristics of angular contact ball bearings are closely related to the thermal failure of high-speed spindle systems. This paper establishes a closed-loop iterative model for analyzing the ball–race contact characteristics of machine tool spindle bearings at different combined loads and oil supply temperatures, based on a five-degree-of-freedom quasi-static analysis model and the finite difference method. Additionally, the accuracy of the proposed model is verified by comparing the measured values of temperature rise with the predicted values. Based on the verification of the accuracy of the model, the contact characteristics of machine tool spindle bearings under strong asymmetric loads and high-temperature lubrication oil are discussed in detail. The results show that at elevated temperatures, the internal loads of angular contact ball bearings operating under combined loads become concentrated, which will lead to reduced fatigue life of the bearings and even thermal seizure.
Experimental Measurement of Ice-Curling Stone Friction Coefficient Based on Computer Vision Technology: A Case Study of “Ice Cube” for 2022 Beijing Winter Olympics
Authors: Li Junxing , Li Shuaiyu , Zhang Wenyuan , Wei Bo , Yang Qiyong
Published: October 2022

In the curling sport, the coefficient of friction between the curling stone and pebbled ice is crucial to predict the motion trajectory. However, the theoretical and experimental investigations on stone–ice friction are limited, mainly due to the limitations of the field measurement techniques and the inadequacy of the experimental data from professional curling rinks. In this paper, on-site measurement of the stone–ice friction coefficient in a prefabricated ice rink for the Beijing Winter Olympics curling event was carried out based on computer vision technology. Firstly, a procedure to determine the location of the curling stone was proposed using YOLO-V3 (You Only Look Once, Version 3) deep neural networks and the CSRT Object tracking algorithm. Video data was recorded during the curling stone throwing experiments, and the friction coefficient was extracted. Furthermore, the influence of the sliding velocity on the friction coefficient was discussed. Comparison with published experimental data and models and verification of the obtained results, using a sensor-based method, were conducted. Results show that the coefficient of friction (ranging from 0.006 to 0.016) decreased with increasing sliding velocity, due to the presence of a liquid-like layer. Our obtained results were consistent with the literature data and the friction model of Lozowski. In addition, the experimental results of the computer vision technique method and the accelerometer sensor method showed remarkable agreement, supporting the accuracy and reliability of our proposed measurement procedure based on deep learning.
Role of Nanofluid Minimum Quantity Lubrication (NMQL) in Machining Application
Authors: Shah Raj , Shirvani Khosro A. , Przyborowski Alexandra , Pai Nikhil , Mosleh Mohsen
Published: October 2022

Gaining grounds as a potential heat transfer fluid due to its superior thermal and tribological properties, Nanofluid Minimum Quantity Lubrication (NMQL) has been classified as an environmentally friendly technique and has already been successfully applied in several machining processes. This paper presents a review of the role of NMQL for different machining processes. The mechanisms of the MQL technique are thoroughly explained for achieving optimal performance based on parameters like nozzle feed position, angle of elevation, distance from the nozzle tip to cutting zone, flow rate, and air pressure. NMQL is shown to enhance cooling performance and lubrication, as well as the tribological properties of the fluid and cutting performance. With government legislative and public opinion pushing manufacturing companies towards sustainable production techniques and practices, the implementation of MQL-nanofluid can slowly prevent the adverse effects that conventional cutting fluids contribute.
Bearing Fault Diagnosis for Time-Varying System Using Vibration–Speed Fusion Network Based on Self-Attention and Sparse Feature Extraction
Authors: Chi Fulin , Yang Xinyu , Shao Siyu , Zhang Qiang
Published: October 2022

Nowadays, most deep-learning-based bearing fault diagnosis methods are studied under the condition of steady speed, while the performance of these models cannot be fully played under time-varying conditions. Therefore, in order to facilitate the practical application of a deep learning model in bearing fault diagnosis, a vibration–speed fusion network is proposed, which utilizes a transformer with a self-attention module to extract vibration features and utilizes a sparse autoencoder (SAE) network to extract sparse features from speed pulse signal. The vibration–speed fusion network enables the efficient fusion of different signals in a high-dimensional vector space with a high degree of model interpretability, without additional signal processing steps. After tuning the hyperparameters of the network, the key segments of the bearing’s time-domain vibration signals can be optimally extracted, the network performance is much better than traditional deep learning methods, and the classification accuracy can reach 95.18% and 99.85% on the two public bearing datasets from the Xi’an Jiaotong University and the University of Ottawa.
Binuclear Nickel Complexes of a New Di(hydroxyphenyl)imidazolate
Authors: Nikovskiy Igor A. , Karnaukh Kseniia M. , Aleshin Dmitry Yu. , Spiridonov Kirill A. , Danshina Anastasia A. , Nelyubina Yulia V. , Polezhaev Alexander V. , Novikov Valentin V.
Published: October 2022

Here, we report a new di(hydroxyphenyl)imidazolate ligand with an N2O2 donor set synthesized by a modified Debus–Radziszewski procedure. Its binuclear nickel(II) complexes feature a weak antiferromagnetic interaction with J12 = −3.16 cm−1 between the two nickel(II) ions identified by magnetometry measurements. As follows from cyclic voltammetry experiments and DFT calculations, they undergo ligand-centered oxidation via the formation of cation radicals with short lifetimes that can be potentially stabilized by bulkier t-butyl groups in the ortho-positions of the ligand. The reported ligand widens the range of the building blocks available to molecular magnetism community and thus provides new ways to the design of magnetic materials with switchable properties.
On a Combinatorial Approach to Studying the Steiner Diameter of a Graph and Its Line Graph
Authors: Liu Hongfang , Shen Zhizhang , Yang Chenxu , Das Kinkar Chandra
Published: October 2022

In 1989, Chartrand, Oellermann, Tian and Zou introduced the Steiner distance for graphs. This is a natural generalization of the classical graph distance concept. Let Γ be a connected graph of order at least 2, and S\V(Γ). Then, the minimum size among all the connected subgraphs whose vertex sets contain S is the Steiner distancedΓ(S) among the vertices of S. The Steiner k-eccentricity ek(v) of a vertex v of Γ is defined by ek(v)=max{dΓ(S)|S\V(Γ),|S|=k,andv∈S}, where n and k are two integers, with 2≤k≤n, and the Steiner k-diameter of Γ is defined by sdiamk(Γ)=max{ek(v)|v∈V(Γ)}. In this paper, we present an algorithm to derive the Steiner distance of a graph; in addition, we obtain a relationship between the Steiner k-diameter of a graph and its line graph. We study various properties of the Steiner diameter through a combinatorial approach. Moreover, we characterize graph Γ when sdiamk(Γ) is given, and we determine sdiamk(Γ) for some special graphs. We also discuss some of the applications of Steiner diameter, including one in education networks.
Active Disturbance Rejection Strategy for Distance and Formation Angle Decentralized Control in Differential-Drive Mobile Robots
Authors: Ramírez-Neria Mario , González-Sierra Jaime , Luviano-Juárez Alberto , Lozada-Castillo Norma , Madonski Rafal
Published: October 2022

The important practical problem of robust synchronization in distance and orientation for a class of differential-drive mobile robots is tackled in this work as an active disturbance rejection control (ADRC) problem. To solve it, a kinematic model of the governed system is first developed based on the distance and formation angle between the agents. Then, a special high-order extended state observer is designed to collectively estimate the perturbations (formed by longitudinal and lateral slipping parameters) that affect the kinematic model. Finally, a custom error-based ADRC approach is designed and applied assuming that the distance and orientation between the agents are the only available measurements. The proposed control strategy does not need time-derivatives of the reference trajectory, which increases the practical appeal of the proposed solution. The experimental results, obtained in laboratory conditions with a set of differential-drive mobile robots operating in a leader–follower configuration, show the effectiveness of the proposed governing scheme in terms of trajectory tracking and disturbance rejection.
Theoretical and Numerical Study of Self-Organizing Processes in a Closed System Classical Oscillator and Random Environment
Authors: Gevorkyan Ashot S. , Bogdanov Aleksander V. , Mareev Vladimir V. , Movsesyan Koryun A.
Published: October 2022

A self-organizing joint system classical oscillator–random environment is considered within the framework of a complex probabilistic process that satisfies a Langevin-type stochastic differential equation. Various types of randomness generated by the environment are considered. In the limit of statistical equilibrium (SEq), second-order partial differential equations (PDE) are derived that describe the distribution of classical environmental fields. The mathematical expectation of the oscillator trajectory is constructed in the form of a functional-integral representation, which, in the SEq limit, is compactified into a two-dimensional integral representation with an integrand: the solution of the second-order complex PDE. It is proved that the complex PDE in the general case is reduced to two independent PDEs of the second order with spatially deviating arguments. The geometric and topological features of the two-dimensional subspace on which these equations arise are studied in detail. An algorithm for parallel modeling of the problem has been developed.
A Transfer Learning for Line-Based Portrait Sketch
Authors: Kim Hyungbum , Oh Junyoung , Yang Heekyung
Published: October 2022

This paper presents a transfer learning-based framework that produces line-based portrait sketch images from portraits. The proposed framework produces sketch images using a GAN architecture, which is trained through a pseudo-sketch image dataset. The pseudo-sketch image dataset is constructed from a single artist-created portrait sketch using a style transfer model with a series of postprocessing schemes. The proposed framework successfully produces portrait sketch images for portraits of various poses, expressions and illuminations. The excellence of the proposed model is proved by comparing the produced results with those from the existing works.
Comparison of Hybrid Abdominal Flap versus Homodigital Neurovascular Island Flap for Fingertip Amputation
Authors: Kim Yung Hoon , Kim Tae Hyung , Park Jun Ho
Published: October 2022

Amputation at the level of the distal phalanx is a common hand injury and is normally treated with replantation. However, if the level of injury is distal or the vessels of the stump have been crushed by injury, replantation cannot be a viable option. The aim of this study is to evaluate the functional and aesthetic outcomes of the “hybrid abdominal flap”, which consists of a random-pattern abdominal skin flap and an autologous bone graft. A retrospective analysis was performed on fingertip amputation patients from March 2019 to April 2021. The patients were managed by either hybrid abdominal flaps (HAFs) or homodigital neurovascular island flaps (HNIFs). The functional and aesthetic outcomes were assessed three months after the operations. In this study, a total of 20 fingers were treated with either HAFs or HNIFs. There was a significant difference in the range of motion (ROM) and the scar quality between the two groups. All of the flaps survived without flap necrosis, and non-union of the bone was not observed. The patients were satisfied with the appearance and function of their fingers, including the ROM and sensory aspects. Our novel HAF is a functionally and aesthetically valid option for fingertip amputations with crushed stumps.
Hydrogen Trapping in Laser Powder Bed Fusion 316L Stainless Steel
Authors: Metalnikov Polina , Ben-Hamu Guy , Eliezer Dan
Published: October 2022

In this study, the hydrogen embrittlement (HE) of 316L stainless steel produced by laser powder bed fusion (L-PBF) was investigated by means of hydrogen trapping. The susceptibility of the material to HE is strongly connected to the interaction of hydrogen atoms with volumetric defects in the material. Trapping hydrogen in those defects affects its availability to critical locations where a hydrogen-induced crack can nucleate. Therefore, it is important to study the characteristics of hydrogen traps to better understand the behavior of the material in the hydrogen environment. The hydrogen was introduced into the material via electrochemical charging, and its interactions with various trapping sites were studied through thermal desorption spectroscopy (TDS). The obtained results were compared to conventionally produced 316L stainless steel, and the correlation between microstructure, characteristics of hydrogen traps, and susceptibility to HE is discussed.
Electrochemical Corrosion Behavior of CrFeCoNi and CrMnFeCoNi Coatings in Salt Solution
Authors: Wang Caimei , Yu Yang , He Peng , Zhang Jianjun , Ma Xiaoyu , Zhang Hua , Li Huizhao , Shao Minghao
Published: October 2022

CrFeCoNi and CrMnFeCoNi coatings were prepared by laser remelting method. The grain boundary characteristics distribution of both coatings was investigated by electron backscattered diffraction technique. The results showed that the CrFeCoNi coating exhibited higher fraction of low angle grain boundaries and Σ3 boundaries compared to the CrMnFeCoNi coating. The corrosion properties of the CrFeCoNi and CrMnFeCoNi coatings in 3.5 wt% NaCl solution were identified by electrochemical method and localized electrochemical impedance spectroscopy technique. The results indicated that the CrFeCoNi coating had a higher corrosion resistance than the CrMnFeCoNi coating. The better corrosion resistance of the CrFeCoNi coating could be attributed to the high fraction of Σ3 boundaries and low fraction of the high angle boundaries.
The Dependence of the Strength of a Carbon Fiber/Aluminum Matrix Composite on the Interface Shear Strength between the Matrix and Fiber
Authors: Galyshev Sergei , Atanov Bulat
Published: October 2022

Taking the example of a composite wire with an Al-25% Sn alloy matrix reinforced with carbon fiber, the dependence of composite bending strength on interface shear strength was determined. Samples of the composite wire with different interface shear strengths were obtained by heat treatment at temperatures from 300 to 600 °C. The highest bending strength of 2450 MPa was observed for composite wire samples with the lowest interface shear strength. With an increase in the shear strength of the interface, a decrease in the strength was observed. The study of the surface of carbon fiber extracted from the composite showed that heat treatment led to the formation of aluminum carbide crystals on the fiber surface, the size and number of which increased with increasing temperature. As a result, there was an increase in the shear strength of the interface. The evaluation of the work of fracture of a composite with different strengths of the interface between the matrix and the fiber demonstrated that as the strength of the interface increases, the work of fracture decreases, due to the premature fracture of the composite through crack propagation in one plane. Based on the experimental data, the refined mixture rule according to the Weibull distribution, and an assessment of the critical stress of crack propagation according to the Griffith–Orowan–Irwin concept, the dependence of composite strength on the shear strength of the interface was estimated. Due to this, the critical shear strength was calculated at which the greatest strength of the composite can be achieved, these values being 107 MPa and 2675 MPa, respectively. It is shown that the contribution of the work of overcoming the friction force to the total work of fracture at relatively small values of shear strength can be several times greater than the total contribution of all other types of energy.
Plasma Metabolomics Reveals β-Glucan Improves Muscle Strength and Exercise Capacity in Athletes
Authors: Wang Ruwen , Wu Xianmin , Lin Kaiqing , Guo Shanshan , Hou Yuning , Ma Renyan , Wang Qirong , Wang Ru
Published: October 2022

The present study aimed to assess the changes in muscle strength and plasma metabolites in athletes with β-glucan supplementation. A total of 29 athletes who met the inclusion criteria were recruited for this study (ChiCTR2200058091) and were randomly divided into a placebo group (n = 14) and β-glucan group (n = 15). During the trial, the experimental group received β-glucan supplementation (2 g/d β-glucan) for 4 weeks and the control group received an equal dose of placebo supplementation (0 g/d β-glucan), with both groups maintaining their regular diet and exercise habits during the trial. The athletes’ exercise performance, muscle strength, and plasma metabolome changes were analyzed after 4 weeks of β-glucan supplementation. The results showed a significant increase in mean grip strength (kg), right hand grip strength (kg), left triceps strength (kg), and upper limb muscle mass (kg) in the experimental group after the 4-week intervention compared to the preintervention period (p < 0.05). A comparison of the difference between the two groups after the intervention showed that there were significant differences between the control group and the experimental group in mean grip strength (kg) and right-hand grip strength (kg) (p < 0.05). Athletes in the experimental group showed significant improvements in 1 min double rocking jump (pcs), VO2max (ml/kg-min) (p < 0.05). The β-glucan intake increased the creatine-related pathway metabolites in plasma. Overall, these results suggest that 4 weeks of β-glucan supplementation can improve muscle strength in athletes, with the potential to increase aerobic endurance and enhance immune function, possibly by affecting creatine-related pathways.
An Experimental Investigation on Polarization Process of a PZT-52 Tube Actuator with Interdigitated Electrodes
Authors: Liu Yonggang , Zeng Aoke , Zhang Shuliang , Ma Ruixiang , Du Zhe
Published: October 2022

The manipulator is the key component of the micromanipulator. Using the axial expansion and contraction properties, the piezoelectric tube can drive the manipulator to achieve micro-motion positioning. It is widely used in scanning probe microscopy, fiber stretching and beam scanning. The piezoceramic tube actuator used to have continuous electrodes inside and outside. It is polarized along the radial direction. There are relatively high polarization voltages, but poor axial mechanical properties. A new tubular actuator is presented in this paper by combining interdigitated electrodes and piezoceramic tubes. The preparation, polarization and mesoscopic mechanical properties were investigated. Using Lead Zirconate Titanate (PZT-52) as a substrate, the preparation process of interdigitated electrodes by screen printing was studied. For initial polarization voltage determination, the local characteristic model of the actuator was extracted and the electric field was analyzed by a finite element method. By measuring the actuator’s axial displacement, we measured the actuator’s polarization effect. Various voltages, times and temperatures were evaluated to determine how polarization affects the actuator’s displacement. Optimal polarization conditions are 800 V, 60 min and 150 °C, with a maximum displacement of 0.88 μm generated by a PZT-52 tube actuator with interdigitated electrodes. PZT-52 tube actuators with a continuous electrode cannot be polarized under these conditions. The maximum displacement is 0.47 μm after polarization at 4 kV. Based on the results, the new actuator has a more convenient polarization process and a greater axial displacement from an application standpoint. It provides technical guidance for the preparation and polarization of the piezoceramic tube actuator. There is potential for piezoelectric tubular actuators to be used in a broader range of applications.
Ring-Shaped Piezoelectric 5-DOF Robot for Angular-Planar Motion
Authors: Čeponis Andrius , Mažeika Dalius , Jūrėnas Vytautas , Deltuvienė Dovilė , Bareikis Regimantas
Published: October 2022

This paper provides numerical and experimental investigations of a ring-shaped piezoelectric 5-DOF robot that performs planar and angular motions of spherical payload. The robot consists of a piezoelectric ring glued on a special stainless-steel ring with three spikes oriented in the radial direction of the ring. The spherical payload is placed on top of the piezoelectric ring and is moved or rotated when a particular excitation regime is used. An alumina oxide ball is glued at the end of each spike of the steel ring and is used as contacting element. The spikes are used to transfer vibrations of the piezoelectric ring to contacting elements and to induce the planar motion of the payload. Additionally, three alumina oxide balls are glued on the top surface of the piezoelectric ring and are used to generate rotational motion of the spherical payload by impacting it. Finally, the top electrode of the piezoceramic ring is divided into six equal sections and is used to control the direction of angular and planar motion of the payload. Numerical modeling of the robot showed that vibration modes suitable for angular and planar motions are obtained at a frequency of 28.25 kHz and 41.86 kHz, respectively. Experimental investigation showed that the maximum angular velocity of the payload is 30.12 RPM while the maximum linear motion of the robot is 29.34 mm/s when an excitation voltage of 200 Vp-p was applied and a payload of 25.1 g was used.
Numerical and Experimental Analysis of Shear Stress Influence on Cellular Viability in Serpentine Vascular Channels
Authors: Deshmukh Khemraj , Gupta Saurabh , Mitra Kunal , Bit Arindam
Published: October 2022

3D bioprinting has emerged as a tool for developing in vitro tissue models for studying disease progression and drug development. The objective of the current study was to evaluate the influence of flow driven shear stress on the viability of cultured cells inside the luminal wall of a serpentine network. Fluid–structure interaction was modeled using COMSOL Multiphysics for representing the elasticity of the serpentine wall. Experimental analysis of the serpentine model was performed on the basis of a desirable inlet flow boundary condition for which the most homogeneously distributed wall shear stress had been obtained from numerical study. A blend of Gelatin-methacryloyl (GelMA) and PEGDA200 PhotoInk was used as a bioink for printing the serpentine network, while facilitating cell growth within the pores of the gelatin substrate. Human umbilical vein endothelial cells were seeded into the channels of the network to simulate the blood vessels. A Live-Dead assay was performed over a period of 14 days to observe the cellular viability in the printed vascular channels. It was observed that cell viability increases when the seeded cells were exposed to the evenly distributed shear stresses at an input flow rate of 4.62 mm/min of the culture media, similar to that predicted in the numerical model with the same inlet boundary condition. It leads to recruitment of a large number of focal adhesion point nodes on cellular membrane, emphasizing the influence of such phenomena on promoting cellular morphologies.
Molecular Characterization and Antibiotic Susceptibility of Non-PCV13 Pneumococcal Serotypes among Vaccinated Children in Cape Coast, Ghana
Authors: Mills Richael O. , Abdullah Mohammed R. , Akwetey Samuel A. , Sappor Dorcas C. , Bolivar Johan A. , Gámez Gustavo , van der Linden Mark P. G. , Hammerschmidt Sven
Published: October 2022

Preventive strategies involving the use of pneumococcal conjugate vaccines (PCVs) are known to drastically reduce pneumococcal disease. However, PCV vaccination has been plagued with serotype replacement by non-PCV serotypes. In this study, we describe the prevalence and molecular characteristics of non-PCV13 serotypes (non-vaccine serotypes, NVTs) from pneumococcal carriage isolates obtained from children < 5 years old in Cape Coast, Ghana, after PCV introduction. The isolates were subjected to antibiotic susceptibility testing and multilocus sequence typing (MLST), and molecular techniques were used to detect the presence of virulence genes. Serotypes 11A, 13, 15B, 23B, and 34 formed the top five of the 93 NVT isolates. As such, 20 (21.5%), 49 (48.4%), and 70 (74.3%) isolates were non-susceptible to penicillin, tetracycline, and cotrimoxazole, respectively. Sixteen (17.2%) multidrug-resistant isolates were identified. However, non-susceptibility to ceftriaxone and erythromycin was low and all isolates were fully susceptible to levofloxacin, linezolid, and vancomycin. Whereas pcpA, pavB, lytA, and psrP genes were detected in nearly all serotypes, pilus islet genes were limited to serotypes 11A, 13, and 23B. MLST for predominant serotype 23B isolates revealed three known and seven novel sequence types (STs). ST172 and novel ST15111 were the most dominant and both STs were related to PMEN clone Columbia23F-26 (ST338). In conclusion, non-PCV13 serotype 23B was the most prevalent, with characteristics of rapid clonal expansion of ST172 and ST15111, which are related to international clones of the pneumococcus. Continuous monitoring of NVTs in Ghana is, therefore, essential, as they have the potential to cause invasive disease, show high antibiotic resistance, and attenuate the effects of PCV vaccination.
Polyhydroxyalkanoate (PHA) Biopolymer Synthesis by Marine Bacteria of the Malaysian Coral Triangle Region and Mining for PHA Synthase Genes
Authors: Alsaadi Athraa , Ganesen Sree Selva Kumar , Amelia Tan Suet May , Moanis Radwa , Peeters Eveline , Vigneswari Sevakumaran , Bhubalan Kesaven
Published: October 2022

Polyhydroxyalkanoate (PHA), a biodegradable and plastic-like biopolymer, has been receiving research and industrial attention due to severe plastic pollution, resource depletion, and global waste issues. This has spurred the isolation and characterisation of novel PHA-producing strains through cultivation and non-cultivation approaches, with a particular interest in genes encoding PHA synthesis pathways. Since sea sponges and sediment are marine benthic habitats known to be rich in microbial diversity, sponge tissues (Xestospongia muta and Aaptos aaptos) and sediment samples were collected in this study from Redang and Bidong islands located in the Malaysian Coral Triangle region. PHA synthase (phaC) genes were identified from sediment-associated bacterial strains using a cultivation approach and from sponge-associated bacterial metagenomes using a non-cultivation approach. In addition, phylogenetic diversity profiling was performed for the sponge-associated bacterial community using 16S ribosomal ribonucleic acid (16S rRNA) amplicon sequencing to screen for the potential presence of PHA-producer taxa. A total of three phaC genes from the bacterial metagenome of Aaptos and three phaC genes from sediment isolates (Sphingobacterium mizutaii UMTKB-6, Alcaligenes faecalis UMTKB-7, Acinetobacter calcoaceticus UMTKB-8) were identified. Produced PHA polymers were shown to be composed of 5C to nC monomers, with previously unreported PHA-producing ability of the S. mizutaii strain, as well as a 3-hydroxyvalerate-synthesising ability without precursor addition by the A. calcoaceticus strain.
GLP-1 and GLP-2 Orchestrate Intestine Integrity, Gut Microbiota, and Immune System Crosstalk
Authors: Abdalqadir Nyan , Adeli Khosrow
Published: October 2022

The intestine represents the body’s largest interface between internal organs and external environments except for its nutrient and fluid absorption functions. It has the ability to sense numerous endogenous and exogenous signals from both apical and basolateral surfaces and respond through endocrine and neuronal signaling to maintain metabolic homeostasis and energy expenditure. The intestine also harbours the largest population of microbes that interact with the host to maintain human health and diseases. Furthermore, the gut is known as the largest endocrine gland, secreting over 100 peptides and other molecules that act as signaling molecules to regulate human nutrition and physiology. Among these gut-derived hormones, glucagon-like peptide 1 (GLP-1) and -2 have received the most attention due to their critical role in intestinal function and food absorption as well as their application as key drug targets. In this review, we highlight the current state of the literature that has brought into light the importance of GLP-1 and GLP-2 in orchestrating intestine–microbiota–immune system crosstalk to maintain intestinal barrier integrity, inflammation, and metabolic homeostasis.
Mechanical Characteristics of Sandstone under High Temperature and Cyclic Loading in Underground Coal Gasification
Authors: Luo Ji’an , He Jun
Published: October 2022

In the process of underground gasification of coal, the top rock of coal seam will experience a certain high temperature action and be in a complex stress environment. Therefore, it is of great theoretical and engineering significance to study the effect of cyclic unloading and loading on mechanical properties of rocks under high temperature action. In this thesis, the stress–strain curves of sandstone under different high-temperature treatments are obtained by conducting graded loading and unloading tests on sandstone treated at room temperature and at 200 °C, 400 °C, 600 °C, and 800 °C, respectively. The research content of this paper is as follows: the peak stress, peak strain, elastic modulus, Poisson’s ratio, internal friction angle, and cohesion of sandstone in the destruction stage of sandstone. The results show that the peak strain and cohesion of sandstone show an increasing trend with the increase of temperature from room temperature to 800 °C; the peak stress shows a decreasing trend with the increase of temperature from room temperature to 800 °C; the modulus of elasticity tends to increase from 200 °C to 400 °C and to decrease with temperature in the rest of the period; the Poisson’s ratio tends to increase from 600 °C to 800 °C and to decrease with temperature in the rest of the period; the internal friction angle increases sharply within room temperature to 200 °C, decreases slowly within 200–600 °C, and decreases sharply when the temperature exceeds 600 °C. The results of the study will provide important reference significance for the design and engineering application of the gasifier of a coal-bed underground gasification project.
Asphaltene Behavior during Thermal Recovery: A Molecular Study Based on Realistic Structures
Authors: Alafnan Saad
Published: October 2022

Asphaltene precipitation and deposition can occur at both the surface and subsurface levels, leading to the formation of organic-based scales. Asphaltene precipitation can also lead to changes in petrophysical properties such as wettability, which affects the ultimate recovery. Asphaltene precipitation is linked to changes in fluid composition driven by pressure drawdown and temperature variation across the reservoir. Thus, asphaltene deposition can adversely influence the ultimate recovery. Thermal recovery methods are invoked to mitigate the adverse effects of asphaltene precipitation. The behavior of asphaltene under thermal recovery along with the link between the asphaltene molecular structure and its response to the increase in temperature during thermal recovery are not fully understood. In this paper, realistic asphaltene structures based on actual crude samples were recreated on a computational platform, and several characteristics of the asphaltene structures (density, viscosity, and interfacial tension) were evaluated during the heating process. The density of asphaltene was correlated with the percentage of aromatic carbon in its structure. The viscosity and interfacial tension decreased substantially as the temperature increased. The IFT reduced by approximately 30 mN/m as the temperature was increased from 300 K to 450 K. Moreover, the mechanical stability of asphaltene was found to be highly influenced by heating. The findings provide nanoscale insights into the behavior of asphaltene during thermal recovery, which can be used to improve the design of thermal recovery processes.
Inhibitory Effects of Myriocin on Non-Enzymatic Glycation of Bovine Serum Albumin
Authors: He Libo , Liu Yang , Xu Junling , Li Jingjing , Cheng Guohua , Cai Jiaxiu , Dang Jinye , Yu Meng , Wang Weiyan , Duan Wei , Liu Ke
Published: October 2022

Advanced glycation end products (AGEs) are the compounds produced by non-enzymatic glycation of proteins, which are involved in diabetic-related complications. To investigate the potential anti-glycation activity of Myriocin (Myr), a fungal metabolite of Cordyceps, the effect of Myr on the formation of AGEs resulted from the glycation of bovine serum albumin (BSA) and the interaction between Myr and BSA were studied by multiple spectroscopic techniques and computational simulations. We found that Myr inhibited the formation of AGEs at the end stage of glycation reaction and exhibited strong anti-fibrillation activity. Spectroscopic analysis revealed that Myr quenched the fluorescence of BSA in a static process, with the possible formation of a complex (approximate molar ratio of 1:1). The binding between BSA and Myr mainly depended on van der Waals interaction, hydrophobic interactions and hydrogen bond. The synchronous fluorescence and UV-visible (UV-vis) spectra results indicated that the conformation of BSA altered in the presence of Myr. The fluorescent probe displacement experiments and molecular docking suggested that Myr primarily bound to binding site 1 (subdomain IIA) of BSA. These findings demonstrate that Myr is a potential anti-glycation agent and provide a theoretical basis for the further functional research of Myr in the prevention and treatment of AGEs-related diseases.
Fostering Need-Supportive Behaviors in Physical Education Teachers and Parents: A Cluster Randomized Controlled Trial Study Protocol of a Web-Based Intervention on Secondary School Students’ Physical Activity
Authors: Meerits Pille-Riin , Tilga Henri , Koka Andre
Published: October 2022

Despite various benefits of physical activity, children are increasingly inactive. Both school physical education classes and support from parents are important determinants of physical activity level of children and adolescents. We aim to develop a web-based intervention for physical education teachers and parents to teach them to be more need-supportive towards children when discussing physical activity and thus increase children’s autonomous motivation towards it. The study will adopt a waitlist-control design with cluster randomization by schools. The intervention content is based on self-determination theory. Specifically, the teachers and parents will be introduced to a series of motivation and behavior change techniques to help them satisfy the children’s psychological needs for autonomy, competence, and relatedness in physical activity. The targeted group in the six-week intervention is comprised of students aged 12–14 years. The primary outcome variable, physical activity of students, will be assessed via self-report questionnaires at baseline, post-intervention, one-month and six-month follow-up. Web-based intervention programs are cost-effective, allow self-paced learning and enable reaching larger audiences. If this project proves to be effective, a highly valuable web-based solution would be available for PE teachers and parents to help increase students’ physical activity levels.
Polyol-Mediated Synthesis of V2O5–WO3/TiO2 Catalysts for Low-Temperature Selective Catalytic Reduction with Ammonia
Authors: Lee Min Seong , Choi Yeong Jun , Bak Su-Jeong , Son Mingyu , Shin Jeehoon , Lee Duck Hyun
Published: October 2022

We demonstrated highly efficient selective catalytic reduction catalysts by adopting the polyol process, and the prepared catalysts exhibited a high nitrogen oxide (NOX) removal efficiency of 96% at 250 °C. The V2O5 and WO3 catalyst nanoparticles prepared using the polyol process were smaller (~10 nm) than those prepared using the impregnation method (~20 nm), and the small catalyst size enabled an increase in surface area and catalytic acid sites. The NOX removal efficiencies at temperatures between 200 and 250 °C were enhanced by approximately 30% compared to those of the catalysts prepared using the conventional impregnation method. The NH3-temperature-programmed desorption and H2-temperature-programmed reduction results confirmed that the polyol process produced more surface acid sites at low temperatures and enhanced the redox ability. The in situ Fourier-transform infrared spectra further elucidated the fast absorption of NH3 and its reduction with NO and O2 on the prepared catalyst surfaces. This study provides an effective approach to synthesizing efficient low-temperature SCR catalysts and may contribute to further studies related to other catalytic systems.
Modern Advances in Magnetic Materials of Wireless Power Transfer Systems: A Review and New Perspectives
Authors: Wang De’an , Zhang Jiantao , Cui Shumei , Bie Zhi , Song Kai , Zhu Chunbo , Matveevich Milyaev Igor
Published: October 2022

The magnetic coupling resonant wireless power transfer (MCR-WPT) system is considered to be the most promising wireless power transfer (WPT) method because of its considerable transmission power, high transmission efficiency, and acceptable transmission distance. For achieving magnetic concentration, magnetic cores made of magnetic materials are usually added to MCR-WPT systems to enhance the coupling performance. However, with the rapid progress of WPT technology, the traditional magnetic materials gradually become the bottleneck that restricts the system power density enhancement. In order to meet the electromagnetic characteristics requirements of WPT systems, high-performance Mn-Zn and Ni-Zn ferrites, amorphous, nanocrystalline, and metamaterials have been developed rapidly in recent years. This paper introduces an extensive review of the magnetic materials of WPT systems, concluding with the state-of-the-art WPT technology and the development and application of high-performance magnetic materials. In addition, this study offers an exclusive reference to researchers and engineers who are interested in learning about the technology and highlights critical issues to be addressed. Finally, the potential challenges and opportunities of WPT magnetic materials are presented, and the future development directions of the technology are foreseen and discussed.