bluuebunny/crossref_metadata_2025 huggingface dataset:
Politics and Justice at the International Criminal Court
Authors: Steinberg Richard H
Published: September 2024

The International Criminal Court (ICC) is a legal institution embedded in international politics. Politics shaped the Rome Statute of the ICC, which is rooted in norms and rules of European lineage and security interests of party states. Politics constrains and influences the operation of the Court, which has adapted in response to oversight and governance of the Assembly of States Parties, and to political actions extrinsic to institutional rules. The ICC also has political effects in situation states. A brief history shows that application of Rome Statute triggers across state parties with different social conditions skewed geographic distribution of its investigations and prosecutions towards Africa, a structural bias that catalysed a legitimation crisis for the ICC. Subsequent exercises of expansive jurisdiction aimed at nationals of non-African, non-party states – including Israel and some of the world's great powers – have dampened African complaints and advanced the ICC agenda, but intensified non-legitimacy claims by powerful non-party states. To survive, Court organs must follow legal mandates, yet be responsive to pressing international political demands, continuously risking the legitimacy of the ICC as a legal institution and adverse political reactions by antagonised governments. Careful management of the tension between law and politics at the ICC may modestly reduce antagonism towards the Court, but that tension cannot be resolved, and confrontations over the ICC's legitimacy are certain to recur.
A Chapter Homily
Authors: Alleluia Amen.
Published: September 2024

For the Alleluia versicle of the Mass of the Aurora for Christmas Day, the Church has chosen the opening words of Psalm 92: ‘The Lord hath reigned, he is clothed with beauty: the Lord is clothed with strength and hath girded himself with power'. It is with the beauty of our humanity that the Lord has clothed himself today: he has put on the weakness of a child; but he has reigned, the Lord has reigned from the crib, just as he was to reign from the cross, and now reigns in heaven. Like Moses in the ark, today the Lord is found in a crib; and as the Son is counted of greater worth than the servant, so he will lead the new Israel into the Promised Land; for ‘from Egypt I have called my Son'.

It was in an ark that Moses was found; and in an ark that Noe sailed over the waters of the great flood, both, Moses and Noe, bearing with them the seeds of new life.
Rosary Sunday
Authors: McNabb Vincent
Published: September 2024

The Holy Gospel according to St Matthew, chapter ‘...And the
Pharisees being gathered together, Jesus asked them, saying, “What think
ye of Christ: whose son is he?” They say to him,
David’s”.’

I Have to speak to you tonight about the holy Rosary. There are, of
course, ten thousand things to be said about it, the least of which is a
glorious battle on which probably depended the civilisation of the world;
but I am going to allow a little child to lead me and you into the
Rosary.

There are not many trees in London streets, but there are a great number
of children—better than trees of course—and God, in his goodness, often
allows little children to hail me. The other day I was passing through one
of our streets, close at hand, made beautiful with the feet of little
children and their gambols, and two little ones I found suddenly by my side.
I think they must have crossed the little narrow street; I don’t know. I
only know that suddenly I found two little ones by my side. I think their
aggregate age would be about six.
Martha And Mary
Authors: Rievaulx St Aelred Of
Published: September 2024

In one of the castles Jesus entered during his journey, a woman called Martha entertained him in her house. She had a sister called Mary. You have heard from the gospel the great happiness of the two women. Truly, great happiness was Martha's who received such a guest, who waited upon him and was busy in his service. Great happiness was Mary's who recognised the excellence of her guest, who heard his words and tasted his sweetness. The gospel narrates that our Lord Jesus Christ entered one of the castles and a woman called Martha entertained him in her house. She had a sister called Mary who ran to Jesus when he entered and sat down at his feet listening to his words. So closely did she attend to the words of the Lord that she took no heed of anything in the house, not even how much her sister was labouring.
Remedies for Sin
Authors: Pepler Conrad
Published: September 2024

Zacharias, in the most ‘Christian’ passage of his prophecy, describing the Orient who is to come to cleanse sins, says, 'Behold the stone that I have laid before Jesus: upon one stone there are seven eyes: behold I will grave the graving thereof, saith the Lord of hosts; and I will take away the iniquity of that land in one day (3, 9). The prophet is describing the rock of Christ and his saving graces, and he puts before us the principal Remedy for sin in a way which we may find echoed in the Ancren Riwle. After analysing the deadly sins and having realised their proximity to the very core of our being, we may be easily carried away into a negative war against vice, wholly human in its inspiration and, in consequence, Stoic in its effects. We must strive to overcome the evil tendencies of nature, certainly, and we must use to intensity the ascetic practices of mortification, specially designed for the overcoming of the flesh. These are particularly to be looked for in the first way of purgation, which is par excellence the ascetic way. But such activities are primarily penalties for past sins.
The Spiritual Homilies of Macarius of Egypt
Authors: Graef H. C.
Published: September 2024

[The fifty homilies printed in Migne's Patrologia Graece, vol. 34. have until recently been attributed to St Macarius, an Egyptian monk of the fourth century whose miracles are told in Palladius's Lausiac History and Rufinus's History of the Monks. But this authorship has lately been seriously questioned; for some of the teaching contained in the Homilies bears a certain resemblance to the tenets of the heretical sect of the Messalians or Euchites, condemned by the Council of Ephesus in 481. G. L. Marriott, in an article on ‘The Messalians and the Discovery of their Ascetic Book (Harvard Theological Review, vol. xix, No. 2) claims to find most of the eighteen Messalian propositions reproduced in St John of Damascus's De Haeresibus in the Macarian Homilies; but on closer inspection almost all the passages adduced from the latter are capable of a perfectly orthodox interpretation, whereas the condemned propositions are a crude and one-sided exaggeration of their teaching.
The Church's Earliest Hymns
Authors: Potter Roland
Published: September 2024

The Hebrew Psalter became and has been for centuries I the great hymn-book of the Church. The wonder of this A book of ‘Praises’ has, very rightly, been made manifest through its long history. Very closely akin are the Canticles in St Luke's Gospel. These represent a genre of their own: we might say New Testament ideas in Old Testament dress. Thus the Magnificat of our Lady is modelled on the Canticle of Anna (I Sam. 2, I-IO) and recalls the Song of Miriam (Exod. 15, 1-21), the Benedictus echoes the language of psalms and prophecies, and the Nunc Dimittis is redolent of passages in Isaiah.

Alongside the more hebraic traditions of prayer and praise we can discern the beginnings of more specifically Christian, and indeed Christological, hymns.
Hepatic and splenic venous access tract closure using the VASCADE vascular closure system following percutaneous intervention in patients with CHD
Authors: Eilers Lindsay F. , Bansal Manish , Khan Asra , Webb Melissa K. , Qureshi Athar M. , Gowda Srinath T. , Stapleton Gary E.
Published: September 2024

Background:

Hepatic and splenic venous access are specialised techniques used to perform diagnostic and interventional procedures in the cardiac catheterisation laboratory. Bleeding events are the most commonly reported complication following hepatic or splenic venous access. The VASCADE Vascular Closure System (Cardiva Medical Inc. Santa Barbara, CA) is an approved device for closure of femoral vascular access tracts in patients ≥18 years of age. We report our experience using VASCADE to close the hepatic or splenic venous access site in the cardiac catheterisation laboratory.

Methods:

This is a single centre retrospective review of all patients who had percutaneous hepatic or splenic venous access obtained in the cardiac catheterisation laboratory from March 1, 2022 through October 30, 2023 and underwent tract closure with VASCADE.

Results:

Ten patients (six male) underwent 16 procedures (median age and weight 3.5 years and 12.5 kg) with 15 hepatic and two splenic veins accessed. Successful closure of the access tracts with VASCADE was performed in all patients. There were no major adverse events related to closure of the access sites with VASCADE.

Conclusion:

VASCADE can be used following transhepatic and trans-splenic venous access in the cardiac catheterisation laboratory to safely close the access tract and potentially reduce the risk of post-procedural bleeding complications. Further evaluation in a larger cohort of patients is needed to ensure VASCADE is safe for use and provides adequate haemostasis following hepatic or splenic venous access, particularly in children.
Five Factors for Effective Policy to Improve Attitudes towards People with Disability
Authors: Purcal Christiane , Idle Jan , Fisher Karen R. , Robinson Sally , Giuntoli Gianfranco , Newman Christy E.
Published: September 2024

Improving community attitudes and behaviours is core to improving inclusion for people with disability. To identify ways to achieve such change, we analysed data from qualitative interviews with sixty-one expert stakeholders in Australia, informed by our preceding literature review on effective interventions. We identified five themes describing factors with the potential to change attitudes and behaviours to improve inclusion and reduce discrimination: ensuring people with disability have active presence across all life domains; leadership by people with disability, together with organisational and governmental leadership that values the diverse contribution of people with disability; a holistic approach to policy and interventions that targets multiple levels of change; long-term and adequately resourced initiatives to achieve structural and sustained change; and commitment to measuring and monitoring change interventions, to inform decisions and maintain accountability.
Plasma Structure Decay Rates in the Equatorial Ionosphere Are Strongly Coupled by Turbulence
Authors: Ivarsen M. F. , St‐Maurice J.‐P. , Park J. , Klenzing J. , Jin Y. , Lee W.
Published: September 2024

Equatorial plasma irregularities in the ionospheric F‐region proliferate after sunset, causing the most apparent radio scintillation “hot‐spot” in geospace. These irregularities are caused by plasma instabilities, and appear mostly in the form of under‐densities that rise up from the F‐region's bottomside. After an irregularity production peak at sunset, the amplitude of the resulting turbulence decays with time. Analyzing a large database of irregularity spectra observed by one of the European Space Agency's Swarm satellites, we have applied a novel but conceptually simple statistical analysis to the data, finding that turbulence in the F‐region tends to decay with a uniform, scale‐independent rate, thereby confirming and extending the results from an earlier case study. We find evidence for two regimes, one valid post‐sunset (1.4 hr decay rate) and one valid post‐midnight (2.6 hr). Our results should be of utility for large‐scale space weather modeling efforts that are unable to resolve turbulent effects.
Orbital Tuning of Short Reversed Geomagnetic Polarity Intervals in the Cretaceous Normal Polarity Superchron
Authors: Ramos J. M. F. , Savian J. F. , Franco D. R. , Figueiredo M. F. , Leandro C. G. , Frontalini F.
Published: September 2024

While the Cretaceous Normal Polarity Superchron has documented instances of brief reversed polarity intervals, the absence of accurate age determinations for such abrupt shifts poses a challenge in leveraging them as reliable reference tiepoints. This study presents a cyclostratigraphic analysis of gamma‐ray data from the DSDP Site 402A. The identification of Milankovitch cycles allowed us to construct a 405‐kyr astronomically‐tuned age model for two reversed events that occurred in the Aptian. Our results estimate an age of 117.03 ± 0.14 Ma for the Chron M”‐1r” or ISEA and 116.17 ± 0.14 Ma for reversal “2,” with timespans of ∼20 and ∼10 kyr, respectively. Sedimentation patterns are influenced by orbital eccentricity cycles with an average sedimentation rate of 5 cm/kyr. The short time intervals related to these reversals exposes the difficulty in their detection in cores through paleomagnetic analysis as well as in deep‐tow surveys.
Quasi‐Periodic EMIC Waves and Pulsating Ionospheric Perturbations Related to ULF Waves
Authors: Ma Longxing , Yu Yiqun , Tong Xin , Tang Linhui , Liu Wenlong , Cao Jinbin , Wu Jun , Wu Jian
Published: September 2024

Pulsating proton auroras are often attributed to periodic proton precipitation. However, how the proton precipitation is periodically generated in the magnetosphere remains an open issue. Utilizing multi‐point space‐borne and ground‐based observations, this study proposed a potential mechanism responsible for pulsating proton precipitation and intermittent ionospheric electron density disturbances. On 8 September 2017, Pc4 ULF waves and electromagnetic ion cyclotron (EMIC) wave packets were simultaneously observed by Van Allen Probes (RBSP) in the inner magnetosphere. The EMIC wave packets were quasi‐periodically excited at the same frequency as the ULF waves, which resulted in 30–100 keV proton precipitation detected by Low‐Earth‐Orbit (LEO) POES satellites. Meanwhile, conjugate European Incoherent Scatter (EISCAT) radar on the ground observed E‐region electron density enhancements that intermittently appeared nearly at the same frequency as the EMIC wave packets in space. These observations together suggest that ULF waves in the magnetosphere are the ultimate driver that modulates quasi‐periodic EMIC waves to induce proton precipitation and pulsating disturbances in the ionosphere.
Peat Particulate Organic Matter Accepts Electrons During In Situ Incubation in the Anoxic Subsurface of Ombrotrophic Bogs
Authors: Obradović Nikola , Schmitz Rob A. , Haffter Frédéric , Meier Dimitri V. , Lever Mark A. , Schroth Martin H. , Sander Michael
Published: September 2024

Peat particulate organic matter (POM) in the anoxic subsurface of peatlands is increasingly recognized as an important terminal electron acceptor (TEA) in anaerobic respiration. While POM reduction has been demonstrated in laboratory peat‐soil incubations and (electro‐) chemical reduction assays, direct demonstration of POM reduction in peat soils under in situ, field conditions involving quantification of transferred electrons remain missing. Herein, we demonstrate that deployment of an oxidized reference POM in the anoxic, methanogenic subsurface of three ombrotrophic bogs, followed by one year incubation, resulted in the transfer of approximately 150–170 μmol of electrons per gram POM to the deployed reference POM. The capacity of this reduced POM to accept electrons was partially restored upon subsequent exposure to dissolved oxygen. These findings provide direct evidence for POM acting as regenerable and sustainable TEA for anaerobic respiration in temporarily anoxic parts of peat soils. Based on the number of electrons transferred to POM and thermodynamic considerations, we estimate that anaerobic respiration to POM may largely suppress methanogenesis in peat soils, particularly close to the oxic‐anoxic interface across which POM is expected to undergo redox cycling.
Orthodontic bonding in special circumstances
Authors: Burns Angus , Hughes Annie , O’Sullivan Michael
Published: September 2024

This clinical paper provides an in-depth exploration of advanced techniques for bonding orthodontic attachments under special circumstances. Challenges arise when bonding brackets to non-enamel surfaces, such as dental restorations, and in conditions such as amelogenesis imperfecta, which affect enamel integrity. Distinct approaches required for bonding to different restorative materials, including glassy ceramics, zirconia, resin composites and metals, are outlined. Moreover, we describe strategies to manage bonding in conditions including amelogenesis imperfecta, hypodontia and microdontia in a multidisciplinary context.
Synthesis and screening of a library of Lewisx deoxyfluoro-analogues reveals differential recognition by glycan-binding partners
Authors: Hollingsworth Kristian , Di Maio Antonio , Richards Sarah-Jane , Vendeville Jean-Baptiste , Wheatley David E. , Council Claire E. , Keenan Tessa , Ledru Hélène , Chidwick Harriet , Huang Kun , Parmeggiani Fabio , Marchesi Andrea , Chai Wengang , McBerney Ryan , Kamiński Tomasz P. , Balmforth Matthew R. , Tamasanu Alexandra , Finnigan James D. , Young Carl , Warriner Stuart L. , Webb Michael E. , Fascione Martin A. , Flitsch Sabine , Galan M. Carmen , Feizi Ten , Gibson Matthew I. , Liu Yan , Turnbull W. Bruce , Linclau Bruno
Published: September 2024

Glycan-mediated interactions play a crucial role in biology and medicine, influencing signalling, immune responses, and disease pathogenesis. However, the use of glycans in biosensing and diagnostics is limited by cross-reactivity, as certain glycan motifs can be recognised by multiple biologically distinct protein receptors. To address this specificity challenge, we report the enzymatic synthesis of a 150-member library of site-specifically fluorinated Lewisx analogues (‘glycofluoroforms’) using naturally occurring enzymes and fluorinated monosaccharides. Subsequent incorporation of a subset of these glycans into nanoparticles or a microarray revealed a striking spectrum of distinct binding intensities across different proteins that recognise Lewisx. Notably, we show that for two proteins with unique binding sites for Lewisx, glycofluoroforms exhibited enhanced binding to one protein, whilst reduced binding to the other, with selectivity governed by fluorination patterns. We finally showcase the potential diagnostic utility of this approach in glycofluoroform-mediated bacterial toxin detection by lateral flow.
Somatic mutations in 3929 HPV positive cervical cells associated with infection outcome and HPV type
Authors: Pinheiro Maisa , Wentzensen Nicolas , Dean Michael , Yeager Meredith , Chen Zigui , Shastry Amulya , Boland Joseph F. , Bass Sara , Burdett Laurie , Lorey Thomas , Mishra Sambit , Castle Philip E. , Schiffman Mark , Burk Robert D. , Zhu Bin , Mirabello Lisa
Published: September 2024

Invasive cervical cancers (ICC), caused by HPV infections, have a heterogeneous molecular landscape. We investigate the detection, timing, and HPV type specificity of somatic mutations in 3929 HPV-positive exfoliated cervical cell samples from individuals undergoing cervical screening in the U.S. using deep targeted sequencing in ICC cases, precancers, and HPV-positive controls. We discover a subset of hotspot mutations rare in controls (2.6%) but significantly more prevalent in precancers, particularly glandular precancer lesions (10.2%), and cancers (25.7%), supporting their involvement in ICC carcinogenesis. Hotspot mutations differ by HPV type, and HPV18/45-positive ICC are more likely to have multiple hotspot mutations compared to HPV16-positive ICC. The proportion of cells containing hotspot mutations is higher (i.e., higher variant allele fraction) in ICC and mutations are detectable up to 6 years prior to cancer diagnosis. Our findings demonstrate the feasibility of using exfoliated cervical cells for detection of somatic mutations as potential diagnostic biomarkers.
Podocyte-specific KLF6 primes proximal tubule CaMK1D signaling to attenuate diabetic kidney disease
Authors: Gujarati Nehaben A. , Frimpong Bismark O. , Zaidi Malaika , Bronstein Robert , Revelo Monica P. , Haley John D. , Kravets Igor , Guo Yiqing , Mallipattu Sandeep K.
Published: September 2024

Diabetic kidney disease (DKD) is the main cause of chronic kidney disease worldwide. While injury to the podocytes, visceral epithelial cells that comprise the glomerular filtration barrier, drives albuminuria, proximal tubule (PT) dysfunction is the critical mediator of DKD progression. Here, we report that the podocyte-specific induction of human KLF6, a zinc-finger binding transcription factor, attenuates podocyte loss, PT dysfunction, and eventual interstitial fibrosis in a male murine model of DKD. Utilizing combination of snRNA-seq, snATAC-seq, and tandem mass spectrometry, we demonstrate that podocyte-specific KLF6 triggers the release of secretory ApoJ to activate calcium/calmodulin dependent protein kinase 1D (CaMK1D) signaling in neighboring PT cells. CaMK1D is enriched in the first segment of the PT, proximal to the podocytes, and is critical to attenuating mitochondrial fission and restoring mitochondrial function under diabetic conditions. Targeting podocyte-PT signaling by enhancing ApoJ-CaMK1D might be a key therapeutic strategy in attenuating the progression of DKD.
A unified moment tensor potential for silicon, oxygen, and silica
Authors: Zongo Karim , Sun Hao , Ouellet-Plamondon Claudiane , Béland Laurent Karim
Published: September 2024

Si and its oxides have been extensively explored in theoretical research due to their technological importance. Simultaneously describing interatomic interactions within both Si and SiO2 without the use of ab initio methods is considered challenging, given the charge transfers involved. Herein, this challenge is overcome by developing a unified machine learning interatomic potentials describing the Si/SiO2/O system, based on the moment tensor potential (MTP) framework. This MTP is trained using a comprehensive database generated using density functional theory simulations, encompassing diverse crystal structures, point defects, extended defects, and disordered structure. Extensive testing of the MTP is performed, indicating it can describe static and dynamic features of very diverse Si, O, and SiO2 atomic structures with a degree of fidelity approaching that of DFT.
Unobtrusive measurement of cognitive load and physiological signals in uncontrolled environments
Authors: Anders Christoph , Moontaha Sidratul , Real Samik , Arnrich Bert
Published: September 2024

While individuals fail to assess their mental health subjectively in their day-to-day activities, the recent development of consumer-grade wearable devices has enormous potential to monitor daily workload objectively by acquiring physiological signals. Therefore, this work collected consumer-grade physiological signals from twenty-four participants, following a four-hour cognitive load elicitation paradigm with self-chosen tasks in uncontrolled environments and a four-hour mental workload elicitation paradigm in a controlled environment. The recorded dataset of approximately 315 hours consists of electroencephalography, acceleration, electrodermal activity, and photoplethysmogram data balanced across low and high load levels. Participants performed office-like tasks in the controlled environment (mental arithmetic, Stroop, N-Back, and Sudoku) with two defined difficulty levels and in the uncontrolled environments (mainly researching, programming, and writing emails). Each task label was provided by participants using two 5-point Likert scales of mental workload and stress and the pairwise NASA-TLX questionnaire. This data is suitable for developing real-time mental health assessment methods, conducting research on signal processing techniques for challenging environments, and developing personal cognitive load assistants.
Effectiveness of non-pharmaceutical interventions for COVID-19 in USA
Authors: Liu Yuhang , Wang Weihao , Wong Weng-Kee , Zhu Wei
Published: September 2024

Worldwide, governments imposed non-pharmaceutical interventions (NPIs) during the COVID-19 pandemic to contain the pandemic more effectively. We examined the effectiveness of individual NPIs in the United States during the first wave of the pandemic. Three types of analyses were performed. First, a prototypical Bayesian hierarchical model was employed to gauge the effectiveness of five NPIs and they are gathering restriction, restaurant capacity restriction, business closure, school closure, and stay-at-home order in the 42 states with over 100 deaths by the end of the wave. Second, we examined the effectiveness of the face mask mandate, the sixth and most controversial NPI by counterfactual modeling, which is a variant of the prototypical Bayesian hierarchical model allowing us to answer the question of what if the state had imposed the mandate or not. The third analysis used an advanced Bayesian hierarchical model to evaluate the effectiveness of all six NPIs in all 50 states and the District of Columbia, and thereby provide a full-scale estimation of the effectiveness of NPIs and the relative effectiveness of each NPI in the entire United States. Our results have enhanced the collective knowledge on the general effectiveness of NPIs in arresting the spread of COVID-19.
MultiMatch: geometry-informed colocalization in multi-color super-resolution microscopy
Authors: Naas Julia , Nies Giacomo , Li Housen , Stoldt Stefan , Schmitzer Bernhard , Jakobs Stefan , Munk Axel
Published: September 2024

With recent advances in multi-color super-resolution light microscopy, it is possible to simultaneously visualize multiple subunits within biological structures at nanometer resolution. To optimally evaluate and interpret spatial proximity of stainings on such an image, colocalization analysis tools have to be able to integrate prior knowledge on the local geometry of the recorded biological complex. We presentMultiMatchto analyze the abundance and location of chain-like particle arrangements in multi-color microscopy based on multi-marginal optimal unbalanced transport methodology. Our object-based colocalization model statistically addresses the effect of incomplete labeling efficiencies enabling inference on existent, but not fully observable particle chains. We showcase that MultiMatch is able to consistently recover existing chain structures in three-color STED images of DNA origami nanorulers and outperforms geometry-uninformed triplet colocalization methods in this task. MultiMatch generalizes to an arbitrary number of color channels and is provided as a user-friendly Python package comprising colocalization visualizations.
CRISPR-enabled point-of-care genotyping for APOL1 genetic risk assessment
Authors: Greensmith Robert , Lape Isadora T , Riella Cristian V , Schubert Alexander J , Metzger Jakob J , Dighe Anand S , Tan Xiao , Hemmer Bernhard , Rau Josefine , Wendlinger Sarah , Diederich Nora , Schütz Anja , Riella Leonardo V , Kaminski Michael M
Published: September 2024

Detecting genetic variants enables risk factor identification, disease screening, and initiation of preventative therapeutics. However, current methods, relying on hybridization or sequencing, are unsuitable for point-of-care settings. In contrast, CRISPR-based-diagnostics offer high sensitivity and specificity for point-of-care applications. While these methods have predominantly been used for pathogen sensing, their utilization for genotyping is limited. Here, we report a multiplexed CRISPR-based genotyping assay using LwaCas13a, PsmCas13b, and LbaCas12a, enabling the simultaneous detection of six genotypes. We applied this assay to identify genetic variants in the APOL1 gene prevalent among African Americans, which are associated with an 8–30-fold increase in the risk of developing kidney disease. Machine learning facilitated robust analysis across a multicenter clinical cohort of more than 100 patients, accurately identifying their genotypes. In addition, we optimized the readout using a multi-analyte lateral-flow assay demonstrating the ability for simplified genotype determination of clinical samples. Our CRISPR-based genotyping assay enables cost-effective point-of-care genetic variant detection due to its simplicity, versatility, and fast readout.
Cardiovascular health (“Life’s Essential 8”), risk of depression and anxiety: a prospective cohort study
Authors: Liu Shuzhen , Hu Xiangju , Jiang Meijie , Huang Ninghao , Liang Hailun , Zheng Ruimao , Wang Shuyan , Qin Jian , Zhang Zhiyong , Huang Tao , Gao Xu
Published: September 2024

There is a growing interest in the linkage of cardiovascular health (CVH) with depression/anxiety but the evidence of “Life’s Essential 8” CVH score is scarce. We evaluated the associations of CVH score with risk of incident depression/anxiety among ~0.4 million participants. During follow-up, 17,554 incident events with symptoms of either disorder were recorded. Per 100-point decrease in CVH score was associated with an increased risk of incident either disorder (Hazard ratio [HR] = 1.133, 95% confidence interval [CI]:1.114–1.153), depression (HR = 1.205, 95% CI:1.180–1.231), and anxiety (HR = 1.042, 95% CI:1.017–1.069). Per 100-point decrease in health assessments or health behaviors was associated with an increased risk of incident either disorder (HRhealth assessments = 1.085, 95% CI: 1.058–1.113, HRhealth behaviors = 1.217, 95% CI: 1.186–1.250). Poor CVH is a risk factor for the incident late-life depression/anxiety symptoms of middle-aged and older adults, and healthy behaviors could be targeted for the risk assessment and intervention of depression/anxiety.
Electrochemical determination of captopril using a disposable graphite electrode modified with a molecularly imprinted film, accompanied by a ratiometric read-out
Authors: Alanazi Ahmed Z. , Alhazzani Khalid , Ibrahim Hossieny , Ali Al-Montaser Bellah H. , Darweesh Mahmoud , El-Wekil Mohamed M.
Published: September 2024

In this research paper, a novel “signal on–off” ratiometric-based electrochemical platform was developed for the sensitive and selective detection of captopril.
The synthesis of 3D organic–inorganic hybrid heterojunctions of g-C3N4 nanoneedles@Ti3C2 MXene with superior photocatalytic H2 evolution
Authors: He Fang , Mao Yuying , Hu Yan , Wu Jingyang , Xie Enqi , Wang Zhenxing , Li Yuexiang
Published: September 2024

3D organic–inorganic hybrid heterojunctions of g-C3N4 nanoneedles growing on Ti3C2 MXene nanosheets have been successfully constructed through a facile molten salt treatment for efficient charge separation and photocatalytic H2 evolution.
Correction: The Lennard-Jones potential: when (not) to use it
Authors: Wang Xipeng , Ramírez-Hinestrosa Simón , Dobnikar Jure , Frenkel Daan
Published: September 2024

Correction for ‘The Lennard-Jones potential: when (not) to use it’ by Xipeng Wang et al., Phys. Chem. Chem. Phys., 2020, 22, 10624–10633, https://doi.org/10.1039/C9CP05445F.
Correction: Water adsorption lifts the (2 × 1) reconstruction of calcite(104)
Authors: Heggemann Jonas , Aeschlimann Simon , Dickbreder Tobias , Ranawat Yashasvi S. , Bechstein Ralf , Kühnle Angelika , Foster Adam S. , Rahe Philipp
Published: September 2024

Correction for ‘Water adsorption lifts the (2 × 1) reconstruction of calcite(104)’ by Jonas Heggemann et al., Phys. Chem. Chem. Phys., 2024, 26, 21365–21369, https://doi.org/10.1039/D3CP01408H.
Lithio-amphiphilic nanobilayer for high energy density anode-less all-solid-state batteries operating under low stack pressure
Authors: Oh Jihoon , Choi Seung Ho , Kim Heejin , Kim Ji Young , Lee Geung-Jong , Bae Ki Yoon , Lee Taegeun , Lee Nohjoon , Sohn Yeeun , Chung Woo Jun , Choi Jang Wook
Published: September 2024

This study introduces a strategy for anode-less all-solid-state batteries (ALASSBs) that employs a lithiophobic tungsten–lithiophilic magnesium bilayer. This lithio-amphiphilic bilayer design allows fast charging and low-pressure operation.
Cabazitaxel-loaded redox-responsive nanocarrier based on d-alpha-tocopheryl-chitosan and hyaluronic acid for improved anti-tumor efficacy in DMBA-induced breast cancer model
Authors: Jha Abhishek , Kumar Manish , Goswami Pooja , Bharti Kanchan , Manjit Manjit , Gupta Ashutosh , Moorkoth Sudheer , Koch Biplob , Mishra Brahmeshwar
Published: September 2024

The study involved the formulation and evaluation of cabazitaxel loaded d-alpha-tocopheryl succinate/chitosan conjugate (CSVE) and hyaluronic acid (HA) based redox-responsive nanoparticle crosslinked using 3,3′-dithiodipropionic acid (DTPA).
Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling
Authors: Zaman Shadid U. , Pagare Piyusha P. , Ma Hongguang , Hoyle Rosalie G. , Zhang Yan , Li Jiong
Published: September 2024

We designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.
Multi-site esterification: a tunable, reversible strategy to tailor therapeutic peptides for delivery
Authors: Bannon Mark S. , Ellena Jeffrey F. , Gourishankar Aditi S. , Marsh Spencer R. , Trevisan-Silva Dilza , Sherman Nicholas E. , Jourdan L. Jane , Gourdie Robert G. , Letteri Rachel A.
Published: September 2024

Peptides are naturally potent and selective therapeutics with massive potential; however, low cell membrane permeability limits their clinical implementation, particularly for hydrophilic, anionic peptides with intracellular targets.
Principles for designing sustainable and high-strain rate stress wave dissipating materials
Authors: Lee Juho , Park Gyeongmin , Lee Dongju , Shin Jiyun , Ahn Cheol-Hee , Lee Jaejun , Kim Tae Ann
Published: September 2024

An optimal strategy to enhance high-strain stress wave damping capabilities is proposed by using poly(disulfide)s with self-healing and chemical recycling capabilities.
De novo design of type-l photosensitizer agents based on structure-inherent low triplet energy for hypoxia photodynamic therapy
Authors: Ran Xiao-Yun , Xia Wen-Li , Zhang Li-Na , Yu Xiao-Qi , Chen Ping , Xie Kun-Peng , Zhao Yu , Yi Cheng , Li Kun
Published: September 2024

Small-molecule of Type-I photosensitizers (PSs) based on dibenzofulvene were synthesized by lowering the triplet energy levels of the π-conjugation bridge and enhancing donor–acceptor interaction, showing excellent ROS production for anti-tumor.
l-cysteine capped MoS2 QDs for dual-channel imaging and superior Fe3+ ion sensing in biological systems
Authors: Takhar Vishakha , Singh Simranjit , Misra Superb K. , Banerjee Rupak
Published: September 2024

l-Cysteine capped MoS2 QDs are synthesized and employed for dual-channel imaging and superior Fe3+ ion sensing in biological systems.
Correction: New horizons on advanced nanoscale materials for Cultural Heritage conservation
Authors: Mastrangelo Rosangela , Chelazzi David , Baglioni Piero
Published: September 2024

Correction for ‘New horizons on advanced nanoscale materials for Cultural Heritage conservation’ by Rosangela Mastrangelo et al., Nanoscale Horiz., 2024, 9, 566–579, https://doi.org/10.1039/D3NH00383C.
Cholesterol inhibits oxygen permeation through biological membranes: mechanism against double-bond peroxidation
Authors: Boonnoy Phansiri , Janlad Minchakarn , Bagheri Behnaz , Dias Cristiano , Karttunen Mikko , Wong-ekkabut Jirasak
Published: September 2024

Cholesterol decreases oxygen permeability across the unsaturated lipid bilayer.
Simultaneous modulation of cathode/anode and electrolyte interfaces via a nitrile additive for high-energy-density lithium-metal batteries
Authors: Wang Ziye , Wang Yingshuai , Xin Yuhang , Zhou Qingbo , Ding Xiangyu , Liu Lei , Song Tinglu , Wu Feng , Wei Zhongbao , Gao Hongcai
Published: September 2024

Succinonitrile improves the cycle stability of lithium metal batteries and enhances the electrode/electrolyte interface stability.
Finding least-cost net-zero CO2e strategies for the European cement industry using geospatial techno-economic modelling
Authors: Strunge Till , Küng Lukas , Sunny Nixon , Shah Nilay , Renforth Phil , Van der Spek Mijndert
Published: September 2024

Cement production requires location-specific net-zero strategies as the costs of suggested strategies depend on transport of feedstocks or captured CO2. In this article we find least-cost strategies using mixed integer linear programming.
Revealing the mass transfer of proton donors for tailoring hydrogen evolution coupled with manganese electrodeposition
Authors: Tan Cai , Chen Chaoyi , Yang Fan , Li Junqi , Jiang Liangxing , Shi Changping , Yang Jiangyuan , Chen Yuanyu , Yu Lu
Published: September 2024

The implementation of a rotating cylindrical cathode for manganese deposition offers a novel perspective in comprehending the conjugated hydrogen evolution reaction within complex solution systems.
Impact of Cu+ and Cu2+ species on the oxide-metal transition processes of CuxO foams during the CO2RR probed by operando Quick-XAS
Authors: Blaseio S. , Dosche C. , Rahaman M. , Kiran K. , Dworzak A. , Mahrt B. , Broekmann P. , Dutta A. , Oezaslan M.
Published: September 2024

Operando Quick-XAS is used to study the reduction kinetics of CuxO foams during the CO2RR. The oxide-metal transition potential strongly depends on the initial abundance of Cu2+ species, precursor structure and type of chronoamperometric experiment.
Unveiling the ultralow in-plane thermal conductivity in 2D organic–inorganic hybrid perovskite (EA)2PbI4 single crystals
Authors: Wei Pai-Chun , Aktar Nashim , Hu Jia-Kai , Wu Cheng-Chieh , Tung Yung-Hsiang , Yang Chun-Chuen , Giugni Andrea
Published: September 2024

2D organic–inorganic hybrid perovskites EA2PbI4 exhibit ultralow in-plane thermal conductivity, approaching the amorphous limit, due to the exceptionally short phonon mean free paths comparable to the Pb–I bond lengths within the PbI6 octahedra.
Understanding the reaction pathway of lithium borohydride-hydroxide-based multi-component systems for enhanced hydrogen storage
Authors: Munshi Sweta , Walker Gavin S. , Manickam Kandavel , Hansen Thomas , Dornheim Martin , Grant David M.
Published: September 2024

The study examines lithium borohydride-hydroxide systems for hydrogen storage. The LiBH4–3LiOH system releases 6 wt% H2 by 250 °C. Thermal and neutron diffraction provide insights into intermediate phases and a detailed reaction schematic.
Efficient absorption of Cu2WX4 (X = S, Se, and Te) for photovoltaic application: a theoretical study
Authors: Zhang Jiaxi , Li Zhenghao , Che Fengxiao , Li Chong , Han Kai , Yang Hongchao
Published: September 2024

A pronounced absorbance coefficient of ∼105 cm−1 and an ultrahigh power conversion efficiency of 21.3% were achieved for the constructed Cu2WS4/Cu2WTe4 heterobilayer.
Exploring the potential of an Aloe vera and honey extract loaded bi-layered nanofibrous scaffold of PCL-Col and PCL-SBMA mimicking the skin architecture for the treatment of diabetic wounds
Authors: Dhiman Megha , Ghosh Souvik , Singh Thakur Gurjeet , Chauhan Samrat , Roy Partha , Lahiri Debrupa
Published: September 2024

A bilayered nanofibrous scaffold mimicking the native skin architecture is designed with Aloe vera and lychee honey extracts incorporated in individual layers for scar-free skin regeneration in diabetic wounds.
A novel ratiometric optical fiber X-ray sensor based on NaGdF4:Tb/CaAl2O4:Eu/Nd composites
Authors: Wang Yuqing , Zhou Su , Zhao Jingtao , Xu Shiqing , Guo Hai , Lei Lei
Published: September 2024

A ratiometric optical fiber X-ray sensor is developed to realize accurate dose rate detection in various environmental conditions. The maximum relative radiation rate detection sensitivity is up to 9.06% (nGy s−1)−1.
CaMKK2: bridging the gap between Ca2+ signaling and energy-sensing
Authors: McAloon Luke M. , Muller Abbey G. , Nay Kevin , Lu Eudora L. , Smeuninx Benoit , Means Anthony R. , Febbraio Mark A. , Scott John W.
Published: September 2024

Calcium (Ca2+) ions are ubiquitous and indispensable signaling messengers that regulate virtually every cell function. The unique ability of Ca2+ to regulate so many different processes yet cause stimulus specific changes in cell function requires sensing and decoding of Ca2+ signals. Ca2+-sensing proteins, such as calmodulin, decode Ca2+ signals by binding and modifying the function of a diverse range of effector proteins. These effectors include the Ca2+-calmodulin dependent protein kinase kinase-2 (CaMKK2) enzyme, which is the core component of a signaling cascade that plays a key role in important physiological and pathophysiological processes, including brain function and cancer. In addition to its role as a Ca2+ signal decoder, CaMKK2 also serves as an important junction point that connects Ca2+ signaling with energy metabolism. By activating the metabolic regulator AMP-activated protein kinase (AMPK), CaMKK2 integrates Ca2+ signals with cellular energy status, enabling the synchronization of cellular activities regulated by Ca2+ with energy availability. Here, we review the structure, regulation, and function of CaMKK2 and discuss its potential as a treatment target for neurological disorders, metabolic disease, and cancer.
Multi‐layer graphene nanosheets bridging binary aluminium oxide for the synergistic enhancement of thermal conductivity and electrical insulation of silicone resin composite
Authors: Shen Yutan , Li Shikun , Qin Bing , Zhang Chong , Li Wenpeng , Wang Bo , Zhu Zhanwei , Liu Chang
Published: September 2024

The flexible polymer composites usually require high intrinsic thermal conductivity fillers for the applications in thermal management, such as the well‐known graphene, which can, in turn, compromise their electrical insulation properties. Here, the authors developed the silicone resin (SR) composites filled with multi‐layer graphene nanosheets (MGN) and binary alumina (Al2O3), and the microstructure of composites exhibits the dominant skeleton of large‐sized Al2O3 filler and branching of small‐sized Al2O3 fillers features by the size matching effect of optimal binary Al2O3. The introduction of supplementary MGN fillers further increases the face‐to‐face contact probability and bridges the isolated binary Al2O3, which contributes to the high thermal conductivity of 3.0 W·m−1·K−1 under these synergistic effects. The dense and connected ‘Al2O3‐MGN‐Al2O3’ thermal conductive pathway is successfully built, as supported by the numerical simulation and Agari model fitting. Meanwhile, the electrical conductivity caused by MGN can be blocked by the surrounding insulation Al2O3 filler network, exhibiting a high volume resistivity of 1.7 × 1015 Ω · cm. Moreover, the Al2O3/MGN/SR composite films effectively transfer the heat and diminish the hot‐spot temperature by 53.5°C in cooling light emitting diode chip module application.
The effect of the environment-dependent stellar initial mass function on the photometric properties of star-forming galaxies
Authors: Haslbauer Moritz , Yan Zhiqiang , Jerabkova Tereza , Gjergo Eda , Kroupa Pavel , Hasani Zonoozi Akram
Published: September 2024

Context. Observational estimates of galaxy properties, including mass and star formation rates (SFRs), rely on the inherent galaxy-wide initial mass function (gwIMF), which systematically varies with the global SFR and metallicity, as proposed by the integrated-galactic IMF (IGIMF) theory and supported by empirical evidence.

Aims. We aim to evaluate the influence of the variable gwIMF on various galaxy properties, encompassing the Ks-, K3.6-, and V-band stellar mass-to-light ratio, SFR–luminosity relation, gas depletion timescale, and stellar mass buildup timescale of local star-forming galaxies.

Methods. We incorporate PARSEC and COLIBRI stellar isochrones into the GalIMF code, a galaxy chemical evolution (GCE) model featuring real-time updates of environment-dependent gwIMFs. This newly developed photometric GalIMF (photGalIMF) code allows the calculation of photometric properties for galaxies with diverse stellar populations. Subsequently, we analyze observed luminosities and metallicities of local star-forming galaxies to deduce their stellar masses assuming empirically-motivated SFHs of Local Cosmological Volume galaxies. We also compute SFR–Hα luminosity relations for varying stellar metallicities using a separate stellar population synthesis code based on PÉGASE.

Results. Comparing the IGIMF theory to the canonical universal IMF, our analysis reveals that estimates of the stellar masses and SFRs for local star-forming galaxies differ by factors of approximately 2 and 10, respectively. This disparity yields a well-defined galaxy main sequence extending to dwarf galaxies. The computed gas-depletion timescale increases with gas mass, implying lower star formation efficiencies in more massive galaxies, possibly due to stronger feedback regulation, aligning with theoretical expectations. Additionally, the characteristic stellar mass buildup timescale increases with stellar mass, indicating that massive disk galaxies initiate star formation earlier than their low-mass counterparts.

Conclusions. The photGalIMF code enables self-consistent computations of galactic photometry with GCE modelling adopting an environment-dependent gwIMF. Utilizing K-band and Hα luminosities of galaxies, the outcomes include galaxy mass, SFR, and fitting functions for the SFR correction factor.
Plasma wave survey from Parker Solar Probe observations during Venus gravity assists
Authors: George H. , Malaspina D. M. , Lee-Bellows D. , Gasque L. C. , Goodrich K. , Ma Y. , Curry S.
Published: September 2024

Context. Parker Solar Probe (PSP) performs Venus gravity assists (VGAs) in order to lower its perihelion. PSP takes high-cadence electric and magnetic field observations during these VGAs, providing the opportunity to study plasma waves in Venus’s induced magnetosphere.

Aims. We summarize the plasma environment during these VGAs, including the regions of near-Venus space that PSP traversed and the key boundary crossings. We comprehensively identify Langmuir, ion acoustic, whistler-mode, and ion cyclotron waves during these VGAs and map the location of these waves throughout near-Venus space.

Methods. This study analyzes different data products from the PSP FIELDS instrument suite from throughout the first five VGAs.

Results. We compare the FIELDS instrumentation capabilities to the capabilities of the plasma wave instruments on board the Pioneer Venus Orbiter (PVO) and the Venus Express (VEX). We find that the PVO electric field instrument was well suited to observe Langmuir waves, especially near the bow shock and in the foreshock. However, evaluation of the other plasma waves detected by PSP FIELDS reveals that PVO and VEX would have often been unable to observe key features of these waves modes, including maximum power, bandwidth, and propagation direction. These wave characteristics provide critical information on the wave generation mechanisms and wave-particle interactions, so provide fundamental information on the nature of Venus’s induced magnetosphere.

Conclusions. These results highlight the advances in plasma wave instrumentation capabilities that have been made in the decades since the PVO and VEX eras, and illustrate the value of a plasma wave instrument on a new Venus mission.