bluuebunny/crossref_metadata_2025 huggingface dataset:
The evolution of information technology and commercial biotechnology in the pharma industries
Authors: Ayesha Firdos  , Wang Meng  , Wang Meng  , Dardiri Hasyim  , Qasim Khlaif
Published: October 2022

The essential purpose of the research study is to determine the evolution of information technology and commercial biotechnology in the pharma industries. This research study depends upon data collection methods related to information technology and commercial biotechnology. The research was conducted in china, and the data was collected from Chinese pharma industries through specific questions. We used smart PLS software to measure the data and run results that included significant analysis, indicator correlation, the R square, co-linearity statistical analysis, and the smart PLS Algorithm model and presented the discriminant validity analysis between independent and dependent variables. Information technology is an independent variable, and commercial biotechnology is a dependent variable. Overall result found a positive and significant evolution of information technology and commercial biotechnology in pharma industries. Therefore, information technology shows a vital role in the pharma industry.
The ‘Route from the Varangians to the Greeks’: truth or fiction
Authors: Martynov Vasilii L. , Subetto Dmitry A. , Brylkin Vyacheslav V. , Grekov Ivan M. , Kublicky Yury A. , Orlov Aleksandr V. , Sazonova Irina Ye. , Sokolova Natalia V.
Published: October 2022

The ‘route from the Varangians to the Greeks’ is widely known and often mentioned in research, popular science and educational literature. Much less often is it mentioned that the existence of the trade route is seriously doubted and needs additional evidence. The discussion about the actuality of a ‘route from the Varangians to the Greeks’ has intensified in the recent decade; it mostly involves historians who draw on chronicles, archive materials and literary sources. Although relevant geographical studies focus on small territories and have a limited scope, only they can give a definitive answer to the question of whether it was possible to sail the rivers of the East European Plain between the Baltic and Black Seas in the 8th-11th centuries AD. Of particular importance are studies on the watersheds marking the principal legs of the route. If the watersheds were traversable, the ‘route from the Varangians to the Greeks’ was navigable, and the impassability of watersheds would preclude navigation along the route. Methodologically, the study employs methods and approaches used in physiographical field studies, which have not been applied earlier to the watershed sections of the ‘route from the Varangians to the Greeks’. The central result of the research is the reconstruction of the hydrological features and hydrographic situation of the watershed between the basins of the Neva (River Lovat) and the Western Dvina (River Usvyacha) during the existence of the ‘route from the Varangians to the Greeks’. This reconstruction and the study of the watershed territories, the system of land communication routes and toponymic features of this territory conclusively demonstrate that the ‘way from the Varangians to the Greeks’, or the Baltic-Black Sea waterway, could actually exist.
Comparison of Wake Flow Measurements between 5-Hole Pitot Probes and Laser Doppler Velocimetry in the Ship Propeller Plane
Authors: Pirrone M. , Lindenmuth W.
Published: October 2022

Wake flow measurements have traditionally been made with pitot probes. Most commonly used probes are of the 5-hole spherical and hemispherical head on cylindrical stem variety. A limitation is that the measurement can be intrusive and the probe may not physically fit in the area to be measured. One modern solution uses multi-component Laser Doppler Velocimetry (LDV) to measure the wake profile. A question arises as to how the laser measurements comp are with the pitot probe measurements.

Experimental studies were conducted at the David Taylor Model Basin, Carderock Division, Naval Surface Warfare Center (formerly the David Taylor Research Center) where pitot probe s and LDV measurements were simultaneously collected in the propeller plane of a single screw ship model. No n-simultaneous wake measurements have also been collected on twin screw shaft and strut ship models.

The two flow measurements correlate well at the outer propeller radii. Near the hub or in low-flow regions, the pitot probe axial velocities fall off more rapidly than LDV measurements.
The Large Cavitation Channel
Authors: Etter R. J. , Wilson M. B.
Published: October 2022

The Large Cavitation Channel (LCC) of the David Taylor Model Basin, CDNSWC, is a large variable pressure water tunnel recently put into operation in Memphis, Tennessee. This facility incorporates many of the latest technological concepts in the design of hydrodynamic and hydroacoustic test facilities. This paper discusses a number of the key technical and design issues that had to be addressed first in the basic specifications and then in the final features as constructed. Issues include: size, shape, speed. pressure range, turbulence management, turning vanes, contraction and diffuser, main pump impeller, hydroacoustic considerations of noise sources, quieting, and noise measurement; and operational features involving model size, powering, and measurement of model propulsor thrust and torque.
New Apparatus for Captive Model Testing of Submerged Bodies in Coning Motion
Authors: Lewandowski E. M.
Published: October 2022

A new apparatus has been designed and constructed to measure the hydrodynamic forces and moments on a captive model in coning motion. The apparatus permits examination of the effects of roll angular velocity in combination with other angular and linear velocity components on these forces and moments. The design of the apparatus is described, and some typical results are shown.
A Precision, High Capacity, High Speed, Right Angle Drive Fully Submerged Propulsor Dynamometry System (FSPD)
Authors: Anderson J. , Hampton A.
Published: October 2022

This paper explains the capabilities of a new right angle drive propeller dynamometry system which has recently been put into service at the Carderock Division of the Naval Surface Warfare Center (CDNSWC). The towing carriage mounted Fully Submerged Propulsor Dynamometer (FSPD) was designed to make precision steady state measurements of propeller thrust and torque while moving through the water at high speeds in the towing basin. Experiments may be performed at various depths and shaft inclination angles. The capabilities introduced by this new instrument will make investigations into many phenomena and the measurement of their effects on propeller performance possible.

The FSPD has been used for obtaining the high speed open water performance for the large diameter propulsors used in cavitation experiments at CDNSWC. Experiments have been performed to determine the effects of the variation of propeller depth of submergence and Reynolds Numbers on open water performance. Some preliminary experimental results are presented in this paper.
Correlation of the USMC High Speed Technology Demonstrator and Propulsion System Demonstrator
Authors: Hoyt J. G. , Abramson B. D. , Hayden D. D.
Published: October 2022

The model to full scale correlation in resistance and powering between two scale model USMC waterjet propelled high speed amphibious vehicles is shown. The estimated required thrust for a 0.295 scale model of the High Water Speed Technology Demonstrator and a 0.245 scale model of the Propulsion System Demonstrator are compared to full scale results in a speed range of 5 to 30 knots. Correlation above 22 knots, after correction for air ingestion into the waterjets, is found to be excellent The effects of air ingestion into the waterjets, effect of long time constants to reach steady state, and an apparent hysteresis effect due to acceleration are also discussed.
A Simplified Power Estimation Method for Monohull High-Speed Small Craft
Authors: Lee C. M.
Published: October 2022

This paper presents a summary of the results of a study of the parametric interrelationships between size, weight, hull proportions, propulsion power, and craft speed of modern, high performance, monohull marine craft. The objective of the study was to derive an empirical method for: i) expeditious definition and optimization of hull geometry, and propulsion plant of candidate craft concepts, and ii) assessment of performance claims in boat design proposals and similar technical literature.

Parametric relationships were derived to describe the performance characteristics of high speed craft in terms related to lifting surface theory (i.e aspect ratio and pressure loading of the planing surface) rather than in more conventional "naval architectural" terms such as hull geometry coefficients, slenderness ratio etc. The data provide a fast and convenient method for estimation of propulsion power/speed relationships which requires only limited craft design information and yields results consistent with the precision necessary for the intended usage.

The scope of the paper includes a brief review of the technical approach used to accomplish the work, typical data trends and the charts which provide the basis for the simplified power estimation method. Performance estimates derived by means of the method are compared with data derived from the careful and thorough testing of full-scale craft.
The complexity of trees, universal grammar and economy conditions
Authors: Collins Chris
Published: October 2022

In this squib, I argue that the child faces a severe computational complexity problem in parsing even the simplest of trees: the number of possible trees consistent with UG grows exponentially as a function of the number of lexical items. Economy conditions have the result of drastically decreasing the complexity of the parsing task. I also discuss the relationship between UG, I-language, economy conditions and explanatory adequacy.
Muralist Art as an Exotic Source of Inspiration for Soviet-era Art and for Intelligence Officers: The Artists and the Explorers of Their Work
Authors: Rachlevičiūtė Ramutė
Published: October 2022

The article discusses some exotic sources of artistic inspiration in the Soviet Union, Soviet-era Lithuanian art, and the works inspired by them. It focuses on a non-European source of art – the work of Mexican muralist artists – three greats, los tres grandes, members of the “progressive”, Communist Party José Clemente Orozco (1883–1949), Diego Rivera (1886–1957), and David Alfaro Siqueiros (1896–1974). Even if only partially, taking advantage of the creative achievements of Mexican artists was one of the opportunities to realise some of the aspirations of modernisation during the Soviet era in the form of art, either through sincere admiration or under the guise of socially-engaged interest. The focus is on the mutual Latin-American- Soviet ideological, political, and cultural contexts at the time and the pre-Columbian art that inspired Mexican muralists. It touches on Cuba’s unique role in the socialistcamp as an important mediator between the USA, Western Europe, and the Soviet Union and on the enigmatic figure of Roger Garaudy, the French prophet of modernisation. It presents knowledge that has not come to the attention of scholars, which emerged after glasnost and perestroika or relatively recently, especially through the publication of memoirs of some declassified Soviet intelligence missions, residents, and stories related to these Latin American artists, especially to D. A. Siqueiros and to the researcher of his work, Iosif Grigulevich, an NKVD killer with origins in Lithuania. He had an incredible career as an intelligence officer: after World War II, he led the NKVD residencies in Latin America and did serious diplomatic work representing a foreign country, Costa Rica. His Karaite appearance and the legend he had created made him a Costa Rican citizen, the son of a millionaire, and led him to an incredible career in Costa Rican diplomatic service by becoming an envoy to three countries, Italy, the Vatican, and Yugoslavia. In 1952, Pope Pius XII awarded him with the Order of Malta, and the President of Venezuela with the Order of Francisco de Miranda; he received the highest state awards of Chile, Bolivia, and Uruguay. In 1953, Beria recalled him from Latin America in order to methodically “handle” the experienced Soviet intelligence officers. In the Soviet Union, Grigulevich was left without even a minimum pension, but he did not give up and started writing books, publishing some 20 biographical books about famous people in Latin America (Simon Bolivar, Salvador Allende, and others). In 1965, he defended his dissertation for the degree of candidate of sciences (the equivalent of the doctorate). Before the KGB declassified the information, he was only a corresponding member of the Academy of Sciences of the Soviet Union (1979), a writer, a noted atheist and an art critic who published a book on Siqueiros. The intelligence officer was lucky: he died in his homeland, in bed at his home.
On the Emergence of the Anthroponyms of the Tatars of Lithuania
Authors: Mickienė Ilona
Published: October 2022

Lietuvos totorių vardynas iki pavardžių susidarymo: XVI–XVII amžius. Mokslinių straipsnių rinkinys.
Mujeres migrantes gallegas en la Argentina: una aproximación a su experiencia a través de la “literatura de emigración” (siglo XX).
Authors: Farías Ruy
Published: October 2022

Women are a fundamental historical subject of the Galician overseas migrations, being Argentina the most important American destination, where hundreds of thousands lived, worked, and preserved their culture and transmitted it. However, migratory studies have tended to invisibilize their specific dynamics and experiences as they were traditionally seeing either as mere companions of their countrymen or part of a family reunification phenomena. This misrepresentation complicated the understanding of their reality giving rise to stereotypes and to the undervaluation of their role in the migration process. Therefore, it is necessary to advance in the study of their individual as well as collective realities and experiences to make visible the changes in their daily lives, to which emigration could have given rise. This paper explores the potential that a series of sources considered "emigration literature" in the twentieth century have to that end, including biographies, autobiographies and fictional autobiographies, collective books of testimonies, essays, stories based on real experiences, among other sources that fall under what is called “migration literature.”

La mujer es un sujeto histórico fundamental dentro de las migraciones ultramarinas gallegas. Ningún destino americano fue para ellas tan importante como el argentino, donde centenares de miles vivieron, trabajaron, conservaron y transmitieron su cultura. Sin embargo, los estudios migratorios han invisibilizado sus dinámicas particulares y experiencias, viéndolas tradicionalmente como meras acompañantes de sus paisanos o parte de fenómenos de reagrupación familiar, lo que dificultó la comprensión de su realidad y dio origen a estereotipos y minusvalorizaciones. Es necesario avanzar en el conocimiento de sus realidades individuales y colectivas, visibilizando los cambios (a veces drásticos) que la emigración pudo generar en su vida cotidiana. El presente trabajo explora la potencialidad que para su estudio en el siglo XX tienen una serie de fuentes como las biografías, autobiografías, libros colectivos de testimonios, ensayos y cuentos basados en experiencias reales, entre otros textos englobados bajo el rótulo de “literatura de emigración”.
Arcade Britannia
Authors: Meades Alan
Published: October 2022

The story of the British amusement arcade from the 1800s to the present.

Amusement arcades are an important part of British culture, yet discussions of them tend to be based on American models. Alan Meades, who spent his childhood happily playing in British seaside arcades, presents the history of the arcade from its origins in traveling fairs of the 1800s to the present. Drawing on firsthand accounts of industry members and archival sources, including rare photographs and trade publications, he tells the story of the first arcades, the people who made the machines, the rise of video games, and the legislative and economic challenges spurred by public fears of moral decline.

Arcade Britannia highlights the differences between British and North American arcades, especially in terms of the complex relationship between gambling and amusements. He also underlines Britain's role in introducing coin-operated technologies into Europe, as well as the industry's close links to America and, especially, Japan. He shows how the British arcade is a product of centuries of public play, gambling, entrepreneurship, and mechanization. Examining the arcade's history through technological, social, cultural, biographic, and legislative perspectives, he describes a pendulum shift between control and liberalization, as well as the continued efforts of concerned moralists to limit and regulate public play. Finally, he recounts the impact on the industry of legislative challenges that included vicious taxation, questions of whether copyright law applied to video-game code, and the peculiar moment when every arcade game in Britain was considered a cinema.
Histone H3 clipping is a novel signature of human neutrophil extracellular traps
Authors: Tilley Dorothea Ogmore , Abuabed Ulrike , Zimny Arndt Ursula , Schmid Monika , Florian Stefan , Jungblut Peter R , Brinkmann Volker , Herzig Alf , Zychlinsky Arturo
Published: October 2022

Neutrophils are critical to host defence, executing diverse strategies to perform their antimicrobial and regulatory functions. One tactic is the production of neutrophil extracellular traps (NETs). In response to certain stimuli, neutrophils decondense their lobulated nucleus and release chromatin into the extracellular space through a process called NETosis. However, NETosis, and the subsequent degradation of NETs, can become dysregulated. NETs are proposed to play a role in infectious as well as many non-infection related diseases including cancer, thrombosis, autoimmunity and neurological disease. Consequently, there is a need to develop specific tools for the study of these structures in disease contexts. In this study, we identified a NET-specific histone H3 cleavage event and harnessed this to develop a cleavage site-specific antibody for the detection of human NETs. By microscopy, this antibody distinguishes NETs from chromatin in purified and mixed cell samples. It also detects NETs in tissue sections. We propose this antibody as a new tool to detect and quantify NETs.
Comprehensive machine-learning survival framework develops a consensus model in large-scale multicenter cohorts for pancreatic cancer
Authors: Wang Libo , Liu Zaoqu , Liang Ruopeng , Wang Weijie , Zhu Rongtao , Li Jian , Xing Zhe , Weng Siyuan , Han Xinwei , Sun Yu-ling
Published: October 2022

As the most aggressive tumor, the outcome of pancreatic cancer (PACA) has not improved observably over the last decade. Anatomy-based TNM staging does not exactly identify treatment-sensitive patients, and an ideal biomarker is urgently needed for precision medicine. Based on expression files of 1280 patients from 10 multicenter cohorts, we screened 32 consensus prognostic genes. Ten machine-learning algorithms were transformed into 76 combinations, of which we selected the optimal algorithm to construct an artificial intelligence-derived prognostic signature (AIDPS) according to the average C-index in the nine testing cohorts. The results of the training cohort, nine testing cohorts, Meta-Cohort, and three external validation cohorts (290 patients) consistently indicated that AIDPS could accurately predict the prognosis of PACA. After incorporating several vital clinicopathological features and 86 published signatures, AIDPS exhibited robust and dramatically superior predictive capability. Moreover, in other prevalent digestive system tumors, the nine-gene AIDPS could still accurately stratify the prognosis. Of note, our AIDPS had important clinical implications for PACA, and patients with low AIDPS owned a dismal prognosis, higher genomic alterations, and denser immune cell infiltrates as well as were more sensitive to immunotherapy. Meanwhile, the high AIDPS group possessed observably prolonged survival, and panobinostat may be a potential agent for patients with high AIDPS. Overall, our study provides an attractive tool to further guide the clinical management and individualized treatment of PACA.
A life LINE for large viruses
Authors: Koonin Eugene V , Krupovic Mart
Published: October 2022

As long suspected, poxviruses capture host genes through a reverse-transcription process now shown to be mediated by retrotransposons.
Icariside II induces rapid phosphorylation of endothelial nitric oxide synthase via multiple signaling pathways
Authors: Song Wenpeng , Yuan Yiming , Tan Xiaohui , Gu Yangyang , Zeng Jianyu , Song Weidong , Xin Zhongcheng , Fang Dong , Guan Ruili
Published: October 2022

Icariside II, as a favonoid compound derived from epimedium, has been proved to involed in a variety of biological and pharmacological effects such as anti-inflammatory, anti-osteoporosis, anti-oxidation, anti-aging, and anti-cancer but its mechanism is unclear, especially in terms of its effect on post-transcriptional modification of endothelial nitric oxide synthase (eNOS). Phosphorylation of eNOS plays an important role in the synthesis of nitric oxide in endothelial cells, which is closely related to erectile dysfunction, atherosclerosis, Alzheimer’s disease, and other diseases. Our study aims to investigate the effect and mechanism of Icariside II on the rapid phosphorylation of eNOS. In this study, human umbilical vein endothelial cells (HUVECs) were stimulated with Icariside II in the presence or absence of multiple inhibitors (1 µM), including LY294002 (PI3K-inhibitor), MK-2206 (AKT-inhibitor), Bisindolylmaleimide X (AMPK-inhibitor), H-89 (CaMKII-inhibitor), KN-62 (PKA-inhibitor), Dorsomorphin (PKC-inhibitor). The proliferation of HUVECs was assessed using cell counting kit-8 (CCK-8). The release of nitric oxide (NO) within HUVECs was detected via fluorescence probe (DAF-FM). Western blot was used to examine the effect of Icariside II on the expression of eNOS, phosphorylation of eNOS, and common signaling pathways proteins. In this study, Icariside II was found to promote the cell proliferation and rapid NO release in HUVECs. The phosphorylation of eNOS-Ser1177 was significantly increased after Icariside II stimulation and reached a peak at 10 min (p < 0.05). Meanwhile, the phosphorylation of eNOS-Thr495 was significantly decreased after 45 min of stimulation (p < 0.05). Following the intervention with multiple inhibitors, it was found that MK-2206 (AKT inhibitor), LY294002 (PI3K inhibitor), KN-62 (AMPK inhibitor), and Bisindolylmaleimide X (PKC inhibitor) could significantly inhibit the phosphorylation of eNOS-Ser1177 caused by Icariside II (p < 0.05), while MK-2206, LY294002, and Bisindolylmaleimide X reversed the alleviated phosphorylation of eNOS-Thr495. We concluded that Icariside can regulate rapid phosphorylation of eNOS- Ser1177 and eNOS-Thr495 via multiple signaling pathways, resulting in the up-regulation of eNOS and the increased release of NO.
Research on Ideological and Political Practice Based on Innovation and Entrepreneurship Education Courses in Colleges and Universities
Authors: Jinchao Fan , Jiajing Chen , Jinbin Fan
Published: October 2022

Research on ideological and political practice based on innovation and entrepreneurship education courses in colleges and universities is conducted in this paper. The value of practical activities of entrepreneurship education lies in its contribution to the overall development of society and The degree of satisfaction of the needs of comprehensive human development. Therefore, only by establishing the social value of the individual value of the individual, the personal value of the society, and the self-value of the individual are intrinsically unified. The effectiveness of entrepreneurship education can be improved only by establishing the concept of entrepreneurship education with the inner unity of individual social value, individual value of society and individual self-value. Education is the pillar and foundation of national innovation system, and university education and postgraduate education are the bases for cultivating high-level innovative talents. This paper gives the novel ideas and the detailed discussions are presented.
Research on the Cultivation Plan of College Students' Autonomous Learning Ability Based On Blended Teaching Mode
Authors: Qin Jianyong
Published: October 2022

Research on the cultivation plan of college students' autonomous learning ability based on blended teaching mode is the main focus of this paper. Self-directed learning is actually metacognitive monitoring of learning It is a process in which students proactively adjust their learning strategies and efforts according to their own learning ability and the requirements of the learning task. The process of Self-directed learning requires individuals to have conscious awareness and response to the questions of why, whether, what, and how they learn. and how to learn. In the process of the teacher-student interaction, learning feedback and online mutual evaluation are the main ways for teachers and students to communicate. We give the new suggestions of improving the performance.
De la primavera de la Iglesia al sofocante verano de la crisis de los abusos en los movimientos y nuevas comunidades
Authors:   Centro de Estudios Filosóficos y Teológicos. Córdoba, Argentina, Duhau Juan Bautista
Published: October 2022

El cambio de perspectivas sobre el abuso que integró en su concepción el abuso espiritual y de autoridad en el contexto de las asimetrías de poder vinculadas al liderazgo carismático puso en primer plano los abusos de todo tipo perpetrados en los nuevos movimientos y comunidades de la Iglesia Católica. En esta publicación nos proponemos estudiar recientes fuentes para analizar este dramático fenómeno: la reflexión del magisterio eclesial, las acciones de vigilancia y remediación de la autoridad pontificia o episcopal al designar gobiernos supletorios, la recepción por parte de organizaciones carismáticas en conflicto de informes independientes como aportes para su sanación y reforma. Además, propondremos las imágenes adulteradas de dos conceptos teológicos como posibles causas de situaciones abusivas en las nuevas comunidades: las falsificaciones de la virtud de la obediencia y el concepto hipertrofiado de carisma de la fundación.
Teacher –Students Relationship and Its Influence on Students’ Academic Performance in Senior Secondary Schools in Sokoto State, Nigeria
Authors: Rabo Maimuna
Published: October 2022

This study was on the teacher –students’ relationship and its influence on students’ academic performance in senior secondary schools in Sokoto state, Nigeria. The study was guided by three research questions among is: To what extent does teacher-student relationship significantly influence students’ academic performance in senior secondary schools in Sokoto state, Nigeria and three null hypotheses among is: There is no significant correlation between teacher-student relationship and students’ academic performance in senior secondary schools in Sokoto state, Nigeria. The researcher adopted correlational research design for this study. This is because it involves finding the relationship between two or variables with the help of structural questionnaire as the instrument for data collection. A population of 10,418 comprising 3,582 teachers and 6,836 students. A sample of 357 was selected using Research Advisors 2006. The self-designed instruments that was used to collect data from both teacher and students include: Teacher –Students Relationship Descriptive Questionnaire (TSRDQ) and Students Academic Performance Test (SAPT). The validity of the two instruments were ascertained by the experts in in test and measurement for content and face validation. Reliability index of (TSRDQ) and (SAPT) were obtained using test re-test and Cronbach alpha formula that yielded 0.83 and 0.75 respectively. The data that were collected was analyzed using simple statistics of mean and standard deviation to answer research questions. Pearson Product Moment Correlation Coefficient (PPMCC) was used to test the null hypothesis one and three while Multiple Regression Analysis was used to test hypothesis 2 at 0.05 alpha level. From the result among other findings, revealed that Effects of cordial relationship between students-teachers and students’ academic performance were positively and significant because teachers found of help in maintaining student interest in the school. Based on the findings, it was concluded by recommending that Both teachers and students should continue to be active in teaching and learning and students should be seen as an important part of the classroom.
Exploring the Relationship between Life Satisfaction and Love-relationship Experiences under the Light of Cognitive Emotion Regulation and Conflict Resolution: The Consequences of their Interplays
Authors: Ali Md. Muztoba , Tahsin Md. Rafat , Sompa Nurunnahar
Published: October 2022

This research focuses on the associations between cognitive emotion regulation processes, conflict resolution strategies and life satisfaction of persons having different types of love and relationship experiences. Cognitive emotion regulation indicates cognitive reactions, related to the emotional involvement, of our brain to an event that attempts to influence the elicited emotions or that event itself. The study is a cross-sectional one with 310 Bangladeshi respondents in the age range 20-34. Several groups and sub-groups were formulated. For the overall sample, satisfaction with life had a statistically significant positive correlation with adaptive cognitive emotion regulation strategies and conflict resolution styles, while it had a statistically significant negative correlation with less-adaptive cognitive emotion regulation strategies (p < 0.01). ANOVA and t-test analysis showed some crucial findings by comparing the primary groups and sub-groups of the study, regarding differences in life satisfaction and the differences in the uses of specific cognitive emotion regulation strategies for various love experiences. Standard regression analysis of data also revealed that the model explained a large portion of variance (50.40%) in life satisfaction (p < .001).
Comparison Level of Financial Distress before and During the Covid-19 Pandemic in Indonesia
Authors: Arisandi Ria , Komalasari Agrianti , Prasetyo Tri Joko
Published: October 2022

The purpose of this study was to determine the level of financial distress that occurred before and for the duration of the Covid-19 pandemic in manufacturing corporations on the Indonesia Stock Exchange. By performing an Altman z-score analysis using five ratios of working capital to total assets, retained earnings to total assets, earnings before interest and taxes to total assets, market value equity to book value of total debt, and sales to total assets. This study is a type of quantitative study that utilizes of secondary data. The data used in the financial statement of the main record board of manufacturing companies was for the period 2017- 2020. The research sample consists of 90 companies. The test was carried out using the Mann-Whitney U Test using the SPSS V.25 program. This study shows that there is no significant difference in the level of financial distress that occurred before and during the Covid-19 pandemic. The results of this study provide recommendation for further researchers, namely in measuring the level of financial distress, they can add or use other analyzes other than the Altman Z-Score. Future researchers can use a longer observation period, especially during the Covid-19 pandemic.
Biochemical and Thermodynamic Characterization of β amylase from Dioscorea alata L.
Authors: Fadunsin M. A. , Ebuehi O. A. T. , Akande I. S. , Kolawole A. O.
Published: October 2022

β-amylase (E.C.3.2.1.2) is a starch hydrolyzing enzyme fondly used in foods, pharmaceuticals, and brewing industries to convert starch into maltose. The aim of this study was to determine the physicochemical, kinetic, and thermodynamic properties, as well as the potential industrial use of β-amylase from Dioscorea alata L. Studying the enzyme stability with Arrhenius methods, showed that the enzyme was stable at a temperature range of 20–500C, and had good pH stability by retaining over 50 % of its initial activity over a wide range of pH from 4 – 8 and kinetic stability by increasing the half-life of the enzyme. The activation energy (Ea) for catalysis by water yam β-amylase at 250C was 6.45kcal/mol. The activation energy (Ea), half-life, free energy change (ΔG‡), enthalpy change (ΔH‡), and entropy change (ΔS‡) for inactivation at optimum temperature (400C) and pH 5 were 13.92 kcal/mol, 41.25 min, 20.89 kcal/mol, 13.30 kcal/mol and -24.25 cal/mol/K respectively. Km and Vmax values were reduced from 2.25 to 2.13mg/ml and 2.95 to 1.48 µmol/min/ml respectively. The optimum pH shifted from 5 to 6, while the Optimum temperature increased from 40 to 500C after immobilization. Enzyme retained up to 67 % activity after 5 cycles. The enzyme would be of importance in manufacturing companies based on the kinetics and application features reported in this study since it is a cheap and readily available source.
Complications of Kidney in Severe Malaria
Authors: Siagian Forman Erwin
Published: October 2022

Malaria is an infectious protozoan parasitic disease transmitted by Anopheles spp mosquito. As a disease entity, malaria is still a major global health problem due to its morbidity and mortality that endangered millions of individuals inhabitants in tropical region. Kidney derangement is moderately frequent in severe malaria caused by the species P. falciparum and also P. malariae, but seldom this condition has also been reported in malaria due to P. vivax. Severe or complicated malaria can occur due to delay or failure of treatment. Making correct and early diagnosis is a prerequisite for successful treatment. Actually, a series of events that begins with the entry of blood protozoa into the host which then causes hemodynamic disturbances and loss of normal capillary capacity. Hemodynamic dysfunction, immune response and with addition from the consequences of severe malaria complications in other organs (e.g., liver) leading to worsening of kidney function in severe malaria. This paper cover the recent findings of kidney involvement in severe malaria and other important facts related to this issue.
Performance of High Yielding Sweet Potato Varieties under Different Seasons
Authors: Mary Jeena , Prameela P. , Menon Syama S. , Vijayan V. Divya
Published: October 2022

In sweet potato, though a number of high yielding varieties are available for cultivation, there is lack of information on suitability of various varieties to different seasons.  The results of the study will be useful to recommend varieties ideal for different seasons. Field experiments were conducted during Kharif, Rabi and Summer seasons from 2021 to 2022 with an objective to assess the seasonal influence on growth and tuber yield of five sweet potato varieties [High yielding varieties were Bhu Krishna (V1), Sree Arun (V2), Sree Bhadra (V3), Bhu Sona (V4) and local variety was Kanjanghad Local (V5)]. Randomized Block Design was followed with four replications. Variety Bhu Sona recorded significantly the highest vine length (211.38 cm) compared to other varieties and variety Sree Bhadra (114.71 cm) and variety Kanjanghad Local (112.54 cm) recorded significantly lower vine length. Sree Arun and Bhu Sona were the superior varieties and recorded significantly higher average tuber weight (236.77 g/plant and 219.14 g/plant, respectively), tuber yield per plant (514.65 g/plant and 404.22 g/plant, respectively) and tuber yield per ha (18.92 tha-1 and 15.96  tha-1, respectively). Rabi season was found ideal for all sweet potato varieties with higher average tuber weight (188.96 g/plant) and tuber yield per ha (20.17 tha-1). Per cent contribution of total dry matter to tuber dry matter was more in Rabi season for Sree Arun and Sree Bhadra varieties. Among the varieties, Sree Arun can be recommended for Rabi and Summer seasons and Bhu Sona for Kharif season.
In-vitro Evaluation of Different Fungicides against Black Leaf Spot Causing Fungus Asperisporium caricae in Papaya
Authors: Shreedevasena S. , Manoranjitham S. K. , Rajendran L. , Parimaladevi R.
Published: October 2022

Ten different contact, systemic and combination products of fungicides were evaluated for their effectiveness against black spot of papaya Asperisporium caricae under in vitro condition by following poisoned food technique. Among fungicides tested, trifloxystrobin 25% + tebuconazole 50% WG, propiconzole 25% EC and zineb 68% + hexaconazole 4% WP were successful in completely (100%) inhibiting the growth of A. caricae at all concentrations (50,100, 250, 500, 750, 1000 ppm) which is followed by hexaconazole 25% EC, difenconazole 25% EC, zineb 68% hexaconazole 4% WP completely inhibited the growth of the fungus at 500 ppm and above concentration. Least inhibition of fungal growth was recorded in copper oxychloride 50% WP at all concentrations. Trifloxystrobin 25% + tebuconazole 50% WG, propiconazole 25% EC and zineb 68% + hexaconzole 4% WP were most effective which completely inhibited the spore germination at all concentrations, while the copper oxychloride 50% WP was recorded the least per cent inhibition of fungal spores.
An Unusual Association of Hyper-IgE Syndrome with Celiac Disease: A Case Report
Authors: Hachim Ghita , Mahi Jihane El , Radi Abdelilah , Ourrai Abdelhakim , Abilkassem Rachid , Hassani Amal , Agadr Aomar
Published: October 2022

Hyper-IgE syndrome (HIES) is a primary immunodeficiency disorder characterized by eczema, cold abscesses, pneumonia, eosinophilia, and a very high serum IgE concentration. An association with celiac disease is rare. Immunodeficiency and autoimmunity are two manifestations of immune system dysfunction that can be associated with common pathophysiological links. We present the case of a 3-year-old child with psychomotor retardation and a history of recurrent infections who had generalized eczema, failure to thrive, and abdominal distension with hepatosplenomegaly. The patient improved after receiving a monthly intravenous immunoglobulin infusion and a gluten-free diet.
Impact of ASEAN- India Free Trade Agreement (AIFTA) on Palm Oil Trade
Authors: Lakshmi B. Teena , Shivakumar K. M. , Kumar D. Suresh , Mahendran K. , Suresh J.
Published: October 2022

Aims: To analyse the trade creation and trade diversion effect of the ASEAN-India Free Trade Agreement (AIFTA) on palm oil trade among the member countries.

Data and Methodology: Data on palm oil exports of major Association of South East Asian countries (ASEAN) member countries such as Indonesia (64.10%), Malaysia (31.52%), Thailand (2.18%), Singapore (1.95%) and Philippines (0.25%) were collected for the period of 21 years (2000–2020) and used for the analysis. The Gravity model by Ordinary Least Square (OLS) and Poisson Pseudo-Maximum Likelihood (PPML) methods were estimated with the panel data.

Results: As expected gravity model variables the distance had a negative impact on the palm oil trade between India and ASEAN member countries. The tariff rates and export prices had a negative impact on the palm oil trade whereas; the population of ASEAN members (exporters), GDP of ASEAN members and exchange rate were insignificant. The AIFTA had a positive and significant effect on the palm oil trade from ASEAN member countries to India which denoted the trade creation effect between ASEAN members and India.

Conclusion: The analysis showed a pure trade creation effect of AIFTA in the time and country fixed effect model. The results suggested that the palm oil trade could be pushed for further trade liberalisation in the AIFTA.
Association Between In-Person vs Telehealth Follow-up and Rates of Repeated Hospital Visits Among Patients Seen in the Emergency Department
Authors: Shah Vivek V. , Villaflores Chad W. , Chuong Linh H. , Leuchter Richard K. , Kilaru Austin S. , Vangala Sitaram , Sarkisian Catherine A.
Published: October 2022

Importance

For patients discharged from the emergency department (ED), timely outpatient in-person follow-up is associated with improved mortality, but the effectiveness of telehealth as follow-up modality is unknown.

Objective

To evaluate whether the rates of ED return visits and hospitalization differ between patients who obtain in-person vs telehealth encounters for post-ED follow-up care.

Design, Setting, and Participants

This retrospective cohort study included adult patients who presented to either of 2 in-system EDs of a single integrated urban academic health system from April 1, 2020, to September 30, 2021; were discharged home; and obtained a follow-up appointment with a primary care physician within 14 days of their index ED visit (15 total days).

Exposures

In-person vs telehealth post–ED discharge follow-up within 14 days.

Main Outcomes and Measures

Multivariable logistic regression was used to estimate the odds of ED return visits (primary outcome) or hospitalization (secondary outcome) within 30 days of an ED visit based on the modality of post–ED discharge follow-up. Models were adjusted for age, sex, primary language, race, ethnicity, Social Vulnerability Index, insurance type, distance to the ED, ambulatory billing codes for the index visit, and the time from ED discharge to follow-up.

Results

Overall, 12 848 patients with 16 987 ED encounters (mean [SD] age, 53 [20] years; 9714 [57%] women; 2009 [12%] Black or African American; 3806 [22%] Hispanic or Latinx; and 9858 [58%] White) were included; 11 818 (70%) obtained in-person follow-up, and 5169 (30%) obtained telehealth follow-up. Overall, 2802 initial ED encounters (17%) led to returns to the ED, and 676 (4%) led to subsequent hospitalization. In adjusted analyses, telehealth vs in-person follow-up visits were associated with increased rates of ED returns (28.3 [95% CI, 11.3-45.3] more ED returns per 1000 encounters) and hospitalizations (10.6 [95% CI, 2.9-18.3] more hospitalizations per 1000 encounters).

Conclusions and Relevance

In this cohort study of patients in an urban integrated health care system, those with telehealth follow-up visits after an ED encounter were more likely to return to the ED and be hospitalized than patients with in-person follow-up. The use of telehealth warrants further evaluation to examine its effectiveness as a modality for continuing care after an initial ED presentation for acute illness.
Assessment of Cystatin C Level for Risk Stratification in Adults With Chronic Kidney Disease
Authors: Lees Jennifer S. , Rutherford Elaine , Stevens Kathryn I. , Chen Debbie C. , Scherzer Rebecca , Estrella Michelle M. , Sullivan Michael K. , Ebert Natalie , Mark Patrick B. , Shlipak Michael G.
Published: October 2022

Importance

Kidney function is usually estimated from serum creatinine level, whereas an alternative glomerular filtration marker (cystatin C level) associates more closely with future risk of cardiovascular disease (CVD) and mortality.

Objectives

To evaluate whether testing concordance between estimated glomerular filtration rates based on cystatin C (eGFRcys) and creatinine (eGFRcr) levels would improve risk stratification for future outcomes and whether estimations differ by age.

Design, Setting, and Participants

A prospective population-based cohort study (UK Biobank), with participants recruited between 2006-2010 with median follow-up of 11.5 (IQR, 10.8-12.2) years; data were collected until August 31, 2020. Participants had eGFRcr greater than or equal to 45 mL/min/1.73 m2, albuminuria (albumin <30 mg/g), and no preexisting CVD or kidney failure.

Exposures

Chronic kidney disease status was categorized by concordance between eGFRcr and eGFRcys across the threshold for hronic kidney disease (CKD) diagnosis (60 mL/min/1.73 m2).

Main Outcomes and Measures

Ten-year probabilities of CVD, mortality, and kidney failure were assessed according to CKD status. Multivariable-adjusted Cox proportional hazards models tested associations between CVD and mortality. Area under the receiving operating curve tested discrimination of eGFRcr and eGFRcys for CVD and mortality. The Net Reclassification Index assessed the usefulness of eGFRcr and eGFRcys for CVD risk stratification. Analyses were stratified by older (age 65-73 years) and younger (age <65 years) age.

Results

There were 428 402 participants: median age was 57 (IQR, 50-63) years and 237 173 (55.4%) were women. Among 76 629 older participants, there were 9335 deaths and 5205 CVD events. Among 351 773 younger participants, there were 14 776 deaths and 9328 CVD events. The 10-year probability of kidney failure was less than 0.1%. Regardless of the eGFRcr, the 10-year probabilities of CVD and mortality were low when eGFRcys was greater than or equal to 60 mL/min/1.73 m2; conversely, with eGFRcys less than 60 mL/min/1.73 m2, 10-year risks were nearly doubled in older adults and more than doubled in younger adults. Use of eGFRcys better discriminated CVD and mortality risk than eGFRcr. Across a 7.5% 10-year risk threshold for CVD, eGFRcys improved case Net Reclassification Index by 0.7% (95% CI, 0.6%-0.8%) in older people and 0.7% (95% CI, 0.7%-0.8%) in younger people; eGFRcr did not add to CVD risk estimation.

Conclusions and Relevance

The findings of this study suggest that eGFRcr 45 to 59 mL/min/1.73 m2 includes a proportion of individuals at low risk and fails to capture a substantial proportion of individuals at high-risk for CVD and mortality. The eGFRcys appears to be more sensitive and specific for CVD and mortality risks in mild CKD.