bluuebunny/crossref_metadata_2025 huggingface dataset:
Towards New Urban Agenda: A Radical Reorientation of Urban Planning Education in India
Authors: Mahadevia Darshini , Bhatia Neha
Published: September 2021

An urbanizing country such as India has its own development challenges given the conditions of dystopias and discontent in the urban areas. In addition, three global agendas, namely the New Urban Agenda, Sustainable Development Goals and the Nationally Determined Contributions towards climate change mitigation also demand actions in the cities. The traditional urban planning approach, based on master/development planning, and stemming from it, urban planning education, is highly technocratic and unable to deal with the reality of development challenges. In addition, urban planning education in India suffers from over-regulation and standardization, which leaves educational institutions devoid of innovation. Thus, for urban planning education to be relevant in India there is a need to revise and broaden the scope of the urban planning profession, non-standardize its contents, pay attention to substantive aspects including issues of equity and sustainability, have a future-facing approach towards dealing with climate change and rethink its pedagogic methods. However, for these changes to occur, urban planning educational institutes must take the lead and initiate radical reforms in country’s higher education regulatory system.
Relationship Between Population Urbanization and Urban Sprawl Across Different City Sizes in China
Authors: Wang Xingfen
Published: September 2021

In this study, a coordination model based on the data of urban population and built-up areas from 2006 to 2015 is used to assess the relationship between population urbanization and urban sprawl across 654 cities in Mainland China. For analysis, 654 cities are divided into five categories (small city, medium city, large city, super city and mega city) and the relationship between population urbanization and urban sprawl is divided into four types (rapid growth of population, rapid expansion of land, shrinkage of population and land and coordinated development between population and land). The results show that 60.6% of cities are rapid expansion of land, 18.5% are rapid growth of population, 14.1% are shrinkage of population and land and only 6.9% of cities are coordinated development between population and land. Small, medium, large and super cities were characterized by rapid expansion of land, while mega cities featured rapid growth of population. The size of the cities decreased mainly because of the shrinkage of people and land while it increased because of the rapid expansion of land. The cities with shrinkage of population and land, and rapid growth of population are mostly distributed in the east of the Hu Line.
Disaster Risk Governance in Bangladesh: How Do NGOs Find Themselves in the Network?
Authors: Johnson Liam , Swapan Mohammad Shahidul Hasan , Ashikuzzaman Md.
Published: September 2021

The roles and responsibilities of state-led organizations have remained the primary focus of disaster risk governance (DRG) literature. While integration of NGOs into formal disaster risk reduction (DRR) has been persistently promoted by the recent United Nations’ DRG frameworks to support state interventions, the low uptake of embracing core principles of DRR by NGOs is noted. Tension within network governance of DRG, including state and non-governmental actors, is also reported by several scholars, particularly in developing countries, but has not been investigated empirically with greater details. To contribute to this research agenda, the study aims to explore how NGOs perceive and value their contributions to DRG. Based on a structured questionnaire survey with development activists (DAs) from NGOs in the southwest coastal region of Bangladesh, the study found that reactive interventions (emergency response and post-disaster support) by them was perceived to be the most critical focus of DRG despite changing theoretical and global perspectives towards pre-disaster preparedness and mitigative measures. Vertical network governance was favoured within NGOs’ own networks outside the state’s direct supervision, identifying a critical role played by local NGOs. The capacity of leadership of NGOs was promoted by the respondents who worked in decision-making positions within their organizations, whilst professionals with lack of experience within the NGO sector tended to favour state actors. The findings could be critical in understanding local capacities and in co-creating hazard specific plans using various stakeholders.
Effect of a synthetic feline facial pheromone product on stress during transport in domestic cats: a randomised controlled pilot study
Authors: Shu Hang , Gu Xianhong
Published: September 2021

Objectives

Transport can be a stressful experience for domestic cats. The objective of this study was to evaluate the effect of a new synthetic feline facial pheromone product on relieving stress in domestic cats during short-distance transport.

Methods

A randomised, blinded, placebo-controlled pilot study was conducted. Prior to baseline screening, cat owners were trained via online meetings in the assessment of stress-related behaviours and overall stress visual analogue scoring. All assessments were completed 30 mins after the start of transport. A total of 150 domestic cats exhibiting stress-related behaviours during baseline screening were recruited and randomly assigned to either the treatment group (n = 75) or the placebo group (n = 75). For the placebo-controlled intervention, the product and placebo, which were identical in appearance, were provided to the treatment and placebo groups, respectively. Fifteen minutes after spraying the carriers with the product or placebo, cat owners were required to take their cat out and complete the same assessments (baseline screening).

Results

After the intervention, the performance of the stress-related behaviours curling, lack of motion and meowing during transport outside the home was significantly reduced in the treatment group compared with the placebo group ( P <0.05). When the baseline stress visual analogue scale (VAS) score was >2.94 cm, cats in the treatment group had significantly lower post-intervention stress VAS scores compared with those in the placebo group ( P <0.05).

Conclusions and relevance

A synthetic feline facial pheromone product can alleviate short-distance transport-related stress in domestic cats with higher stress scores. This finding will benefit domestic cats during transport outside of the home.
Perception of stress in cats by German cat owners and influencing factors regarding veterinary care
Authors: Karn-Buehler Jessica , Kuhne Franziska
Published: September 2021

Objectives

Visiting the veterinarian is generally perceived as a stressful situation for cats. Previous studies have shown that the perception of stress may influence cats’ healthcare. In order to minimise stress in cats during the veterinary consultation, feline-friendly handling has gained importance and is increasingly being used. The aim of this study was to find out whether cats experience stress during a visit to the veterinarian (and, if so, to what extent), and which factors influence the perception of stress and whether feline-friendly handling techniques have an impact.

Methods

An online survey was conducted among German cat owners. In total, 889 questionnaires were evaluated. The results were analysed with binary logistic regression and a χ² test. A principal component analysis was used to detect the main influencing factors on the perception of stress.

Results

Most of the cats (88.7%, n = 732/825) were perceived as stressed during a veterinary consultation, while only about half of the owners (50.8%, n = 419/824) stated that they felt stressed themselves. The cat owners (n = 819) who perceived visiting the veterinarian as a stressful situation also described their cat as stressed significantly more often compared with owners who did not feel stressed (χ² = 101.113, P <0.001). The probability that owners experienced stress themselves was significantly increased if they perceived their cat to be stressed too (odds ratio 0.073, 95% confidence interval 0.016–0.328). One factor that influenced whether an owner was stressed was the stress behaviour of their cat (P <0.001). Furthermore a feline-friendly demeanour by the veterinarian led to less stress in the owners (P <0.001).

Conclusions and relevance

The owner’s stress influences the perception of their cat’s stress. By adhering to feline-friendly handling guidelines, veterinarians can reduce owner stress associated with veterinary visits, thereby promoting optimal veterinary care and health for their feline patients.
Optical coherence tomography angiography in healthy children: A comparison of macular structure
Authors: Plaitano Carmen , Periti Francesca , Guagliano Rosanna , Bertone Chiara , Barillà Donatella , Arpa Cristina , Tinelli Carmine , Gallo Flavio Gioele , Bianchi Alessandro , Magli Adriano
Published: September 2021

Purpose:

The purpose of the present study was to investigate the perfusion density (PD) of macular superficial (SCP) and deep capillary plexus (DCP), the size of foveal avascular zone (FAZ) and central macular thickness (CMT) in healthy children using optical coherence tomography angiography (OCT-A).

Patients and methods:

About 206 eyes of 111 children were analyzed. The correlation of gestational age (GA), birth weight (BW), age, sex, refractive errors, and visual acuity (VA) with OCT-A parameters were investigated.

Results:

The mean PD of the fovea and the mean FAZ area of SCP were 17.1% (DS: 4.26) and 234.47 (DS: 106.39) µm2. The mean PD of the fovea and the mean FAZ area of DCP were 13.5% (DS: 5.23) and 298.32 (DS: 112.37) µm2. Superficial and deep FAZ areas were not correlated with sex, age, BW, refractive errors, or VA. FAZ area of SCP was correlated with foveal PD ( r = −0.76) and with CMT ( r = −0.68). FAZ area of DCP was correlated with foveal’s PD ( r = −0.61). There was no correlation between CMT and refractive errors.

Conclusion:

OCT-A may provide a non-invasive and reliable approach to evaluate macular perfusion in children. As the FAZ area, PD, and CMT change during the growth period, we performed established a reference range for different ages.
Total hip arthroplasty with ultra-short uncemented stem in patients with osteonecrosis of the femoral head: mid-term results
Authors: Necas Libor , Hrubina Maros , Melisik Marian , Cabala Juraj , Cibula Zoltan , Daniel Matej
Published: September 2021

Background:

Mid-term results (clinical and radiographic) of ultra-short anatomical cementless stem total hip arthroplasty (THA) in patients with osteonecrosis of the femoral head (ONFH) has not often been presented. The aim of this study is to evaluate THA using the Proxima stem in patients with ONFH in the mid-term.

Methods:

The study consists of 73 patients (97 THAs) with a Proxima stem implanted between 2006 and 2015. The mean age of patients was 47.4 years, with a mean follow-up 105.2 months. The clinical results include preoperative and postoperative Harris Hip Scores (HHSs). Radiological follow-up reports on stem migration, bony trabecular development and radiolucent lines. The complications and revisions were registered. Kaplan-Meier survival analysis was performed to determine the implant survival.

Results:

The average HHS improved significantly from 40.3 preoperatively to 98.0 at the final evaluation ( p  ˂ 0.0001). Stem migration (subsidence and “varisation”) was observed in 11 hips (in 9 of them up to 6th postoperative month without any further progression, in 2 with progressive migration and radiological loosening). Bony trabecular development was detected in modified Gruen zones (1,2,4,6,7 for Proxima stem): in zone 1 (0%), 2 (67.0%), 4 (64.9%), 6 (64.9%), 7 (0%). Radiolucent lines were observed in 1 cup and 6 stems (2 were loose, 4 with fibrous stable fixation). Complications were found in 5 hips (5.1%): squeezing hip once, repeated dislocation in 1, 1 early deep infection, and 2 loose stems. 2 hips (2.1%) were revised (dislocation, infection). The implant survival was 98.9% and 97.9% clinically and radiologically, respectively.

Conclusions:

Observations in the mid-term show that the clinical and radiological results of the Proxima stem in patients with ONFH are promising. The stem design preserves the proximal femoral bone stock. The bony trabecular appearance confirms physiological proximal femoral load transmission.
Learning from difference and similarity: Identities and relational reflexive learning
Authors: Beech Nic , Brown Andrew D , Coupland Christine , Cutcher Leanne
Published: September 2021

Within organizations there is reciprocal interplay between identity construction and learning. Processes of learning are enabled and constrained by identity practices; concomitantly, the possibilities for learning are shaped by the identity positions available to individuals. There is a dynamic between the impositions of organizations and people’s freedom to shape their identities and learning plays a crucial role in this. Our purpose in this special issue is to contribute to the understanding of the intersection of identity work and learning as a response to experiences of being different. Experiences of difference include moving into a new role, encountering a disjuncture with others while in a role or a difference in broader life which is reacted to as if it were a problem in an organizational setting. Being different produces a variety of challenges and the papers in this special issue trace how people cope with vulnerabilities, develop resilience and often collaborate in their learning. We focus on how people reflect on their own identity and learn and how, by learning together with people who have similar experiences, micro-communities can support, develop and enhance their insight and identity-positions.
RETRACTED: Effect of surface treatment of carbon fibers on the mechanical and frictional properties of polyetheretherketone/polytetrafluoroethylene composites: Experimentation and finite element analysis
Authors: Xiao Wei , Ji Xin
Published: September 2021

Polytetrafluoroethylene has many excellent properties and a wide range of applications, but its poor wear resistance, hardness, and creep resistance have severely limited the use of the polytetrafluoroethylene composites. In this work, the surface of carbon fibers was treated with silane coupling agent acetone solution, and then sintering technology was used to prepare carbon fibers/polyetheretherketone (PEEK)/ polytetrafluoroethylene composites. The mechanical and frictional wear properties of the composites were analyzed using an electronic tensile tester, a Shore hardness tester, and a frictional wear tester, and scanning electron microscopy was applied to analyze the surface morphology of the composites after wear. The experimental results shown that the addition of carbon fibers could significantly improve the mechanical properties of the composites, reduce the radial shrinkage, and increase the Shore hardness of the composites. Under the same experimental conditions, the carbon fibers (20 wt.%) /polyetheretherketone/polytetrafluoroethylene composites has the best wear resistance, with a friction coefficient of 0.196 and the wear rate of 2.41 ×  10−6 mm3/N·m. In the theoretical simulation, the thermal conductivity of polytetrafluoroethylene composites was predicted using ANSYS software, with the changes in the temperature and friction force in the friction process. The theoretical simulation results matched with the experimental values, which proved the accuracy of the theoretical simulations.
Reported communication challenges for adult witnesses with intellectual disabilities giving evidence in court
Authors: Morrison Joanne , Bradshaw Jill , Murphy Glynis
Published: September 2021

Communication plays a key role in a witness's ability to give evidence and participate in the court process. Adults with intellectual disabilities (ID) can be negatively impacted by communication difficulties such as: limitations in recall abilities; suggestibility to leading questions; difficult question styles used by advocates; and unfamiliar language used within the court setting. Most research carried out on communication challenges for adults with ID, when giving evidence, has involved participants in psychology-based experimental methodology. In this study 19 court reports assessing actual witnesses (complainants and defendants) with ID, written by Registered Intermediaries in Northern Ireland, were analysed. A wide range of communication difficulties were identified for the adult witnesses. Difficulties resulting from communication used by their communication partner (typically the advocate in a court setting) were also described. A rich model of the challenges for both partners, in giving evidence and in cross-examination, is presented, extending previous research. This study highlights the need for research within UK courts to assess: how witnesses with ID are being questioned; the effectiveness of changes made to the court process to enhance communication; the impact of the court process and environment on communication and alternative question styles for advocates to use.
Whither, hither and thither, Res Gestae? A comparative analysis of its relevance and application
Authors: Teong Ying Keat Edwin
Published: September 2021

In Singapore, the common law doctrine of r es gestae (‘RG’) risks becoming extinct given the statutory inclusions of hearsay evidence. Further, the test for RG is unsettled. This article thus argues that RG is still relevant but must be applied principally. It is relevant because first, it is unwise to uproot a doctrine existing since 1808. Second, comparative analysis of cases from United Kingdom, India, New Zealand and Australia evinces the residual need for RG. Third, a modified approach to applying it can in fact exclude inadmissible evidence. This article further proposes a three-strand test. First, as a preliminary requirement, objectively, there was no concoction involved. Second, the evidence must relate to a fact-forming part of the same transaction but was not contemplated in s. 32(1) of the Evidence Act. Third, the evidence must have sufficient probative value to outweigh its prejudicial effect.
Interfaces in the returnees’ heritage language: Is the complete (re-)activation possible?
Authors: Antonova-Unlu Elena , Wei Li , Kaya-Soykan Didem
Published: September 2021

Aims and objectives/purpose/research questions:

The aim of this study is to examine whether the complete (re-)activation of interface domains in the heritage language (HL) is possible or whether interfaces are likely to preserve features typical for the HL even after many years of residing in the country of origin.

Design/methodology/approach:

We present the group analysis of direct object marking in Turkish, which is a morphology-syntax-pragmatics interface, of Turkish-German returnees, who returned to Turkey after puberty and have been residing in the country for a minimum of 10 and a maximum of 34 years, and compare them with the control group consisting of Turkish speakers who have been living in Turkey all their lives.

Data and analysis:

The data were collected using a narrative task, a completion task and a grammaticality judgement task, and analysed both quantitatively and qualitatively.

Findings/conclusions:

The analysis of the narrative task revealed that the returnee participants used case-marking on direct objects productively depending on the discourse and syntactic position of the direct object in their heritage Turkish. However, their performance on the completion and grammaticality judgement tasks diverged from those of the control group. These findings can be considered as a piece of evidence that interface domains stay obstinate to complete (re-)activation and may preserve features typical for the HL many years after the return to the country of origin.

Originality:

The study suggests relevance of the Interface Hypothesis to the process of HL (re-)activation.

Significance/implications:

The study contributes to the research on the HL development of returnees after their return to the country of origin.
A systematic review of constructive and solutions journalism research
Authors: Lough Kyser , McIntyre Karen
Published: September 2021

Academic activity surrounding constructive and solutions journalism has surged in recent years; thus, it is important to pause and reflect on this growing body of work in order to understand where the field can and should go in the future. We conducted a systematic review of existing literature on solutions and constructive journalism ( N = 94), in an effort to (1) describe the state of this field by identifying the patterns and trends in the methodological and conceptual approaches, topics, institutions, countries and practices involved in this research, and (2) illuminate potentially important gaps in the field and suggest recommendations for future research.
Enraged and Engaged? Emotions as Motives for Discussing Politics
Authors: Wolak Jennifer , Sokhey Anand Edward
Published: September 2021

The 2016 presidential campaign made some feel angry, while others felt anxious, embarrassed, or enthusiastic. We explore how these emotions relate to patterns of political talk within informal conversation networks. Using items from the 2016 Cooperative Congressional Election Study, we link emotional reactions to rates of conversation, interest in political talk, and exposure to disagreeable viewpoints. Rather than deterring people from contentious conversations, we find that the heightened emotions are associated with greater engagement in political talk. Those who feel angry do not confront their opponents. Instead, they avoid conversations with those who do not share their views, where anger is tied to partisan patterns of political discussion. Feelings of embarrassment have the opposite relationship, as those who felt embarrassed during the campaign were more likely to discuss politics with those with contrary views. These results inform when and how people engage in political talk.
Multiple Primary Tumors Originating From the Prostate and Colorectum A Clinical-Pathological and Therapeutic Challenge
Authors: Dema Sorin , Bota Andreea , Tăban Sorina Maria , Gheju Adelina , Dema Alis Liliana Carmen , Croitor Alexei , Barna Robert Alexandru , Popa Oana , Bardan Răzvan , Cumpănaș Alin-Adrian
Published: September 2021

Considering that the incidence of colorectal (CRC) and prostatic cancer (PC) increases with age, metachronous and synchronous tumors can often affect the same patient. Despite the importance of this subject for the diagnosis and management of oncologic patients, in medical literature the data are scarce. The aim of the study was to evaluate the incidence and the characteristics of double/multiple primary malignant tumors (D/MPMTs) with colorectal and prostatic origin, in patients admitted to a reference hospital in West Romania. A 4-year retrospective observational study (2016–2019) was conducted by analyzing the medical records of all patients admitted in the hospital. Demographic and clinical data, as well as tumor-related parameters, were extracted. We identified 413 consecutive hospitalized patients with PC, and 21 (5%) of them also had a primary CRC. At the time of diagnosis, the mean age of the patients with PC was 71.2 ± 6 years, and 71.8 ± 10 years for patients with CRC. Synchronous PC and CRC tumors were identified in 3/21 cases and metachronous tumors in 18/21 cases. Prostate cancer was the first tumor to be diagnosed in 13/18 cases and CRC in 5/18 cases. The most frequent subtype of PC was acinar adenocarcinoma (90%) and for CRC cases, conventional adenocarcinoma (90%). Prostate and colorectal cancers tend to co-occur in a single patient. The diagnosis of one of these two types of tumors should imply the screening for the other one, because these patients require a multidisciplinary and personalized approach.
Applying the Science of Habit Formation to Evidence-Based Psychological Treatments for Mental Illness
Authors: Harvey Allison G. , Callaway Catherine A. , Zieve Garret G. , Gumport Nicole B. , Armstrong Courtney C.
Published: September 2021

Habits affect nearly every aspect of our physical and mental health. Although the science of habit formation has long been of interest to psychological scientists across disciplines, we propose that applications to clinical psychological science have been insufficiently explored. In particular, evidence-based psychological treatments (EBPTs) are interventions targeting psychological processes that cause and/or maintain mental illness and that have been developed and evaluated scientifically. An implicit goal of EBPTs is to disrupt unwanted habits and develop desired habits. However, there has been insufficient attention given to habit-formation principles, theories, and measures in the development and delivery of EBTPs. Herein we consider whether outcomes following an EBPT would greatly improve if the basic science of habit formation were more fully leveraged. We distill six ingredients that are central to habit formation and demonstrate how these ingredients are relevant to EBPTs. We highlight practice points and an agenda for future research. We propose that there is an urgent need for research to guide the application of the science of habit formation and disruption to the complex “real-life” habits that are the essence of EBPTs.
Recruiting pupils for a school-based eye study in Nigeria: Trust and informed consent concerns
Authors: Maduka-Okafor Ferdinand Chinedum , Okoye Onochie Ike , Oguego Ngozi , Udeh Nnenma , Aghaji Ada , Okoye Obiekwe , Ezegwui Ifeoma R , Nwobi Emmanuel Amaechi , Ezugwu Euzebus , Onwasigwe Ernest , Umeh Rich E , Aneji Chiamaka
Published: September 2021

School-based research presents ethical challenges, especially with respect to informed consent. The manner in which pupils and their parents respond to an invitation to participate in research is likely to depend on several factors, including the level of trust between them and the researchers. This paper describes our recruitment and consent process for a school-based eye study in Nigeria. In the course of our study, a particular governmental incident helped to fuel public mistrust in governmental programs and posed a potential threat to our recruitment efforts. The recruitment and consent process included series of advocacy visits to stakeholders in the education sector, highly interactive briefing and health talk sessions in schools, use of telephone services as a medium for information dissemination, age-appropriate study information, parental consent, and pupil assent. Of the 6598 pupils provided with study information, 5723 returned parental consent forms. There were 69 cases of pupils who dissented despite having parental consent. The two leading concerns for the parents/guardians were the rumors regarding a military/governmental-sponsored health campaign and the side-effects of the dilating eye-drops. Nevertheless, our high level of recruitment suggests our recruitment and consent process was successful in assuaging fears for the vast majority of pupils and their parents.
The role of inhibitory control in shoot/don’t-shoot decisions
Authors: Biggs Adam T , Pettijohn Kyle A
Published: September 2021

Previous work has demonstrated a link between cognitive abilities, specifically inhibitory control and lethal force decision-making performance. However, many previously used approaches to simulating shoot/don’t shoot scenarios have lacked ecological validity. There is a need to investigate how inhibitory control impacts shoot/don’t decisions using realistic simulations to better translate the findings to military and law enforcement settings. This study used multiple cognitive control tasks incorporating discrete judgements in go/no-go and stop signal tasks as well as subjective judgements in go/no-go tasks with both colour stimuli and emotional faces. These combined tasks provided a comprehensive evaluation of inhibitory control abilities. To ensure ecological validity in shooting performance, existing military training scenarios incorporated realistic weaponry and aiming behaviours across different shoot/don’t-shoot simulations. The inhibitory control battery identified five principal components from the various tasks, including: stopping ability, response speed, emotion detection, colour detection, and emotional biases. These principal inhibitory control components were entered into hierarchical linear regressions with the dependent variables of unintended casualties inflicted and lethal rounds fired, respectively. Stopping ability better predicted the likelihood of inflicting an unintended casualty, whereas response speed better predicted the number of lethal rounds fired. These regression models included baseline metrics of marksmanship and shots fired, which supports a role for inhibitory control above and beyond basic shooting abilities or strategy. These collective findings provide mechanistic support for the relationship between inhibitory control and errors in shoot/don’t-shoot decision-making while using realistic military training scenarios.
Therapeutic closure of bronchopleural fistulas using ethanol
Authors: Abramian Osheen , Rosenheck Justin , Taddeo-Kolman Diana , Bowen Francis , Boujaoude Ziad , Abouzgheib Wissam
Published: September 2021

Bronchopleural fistula (BPF) leading to persistent air leak (PAL), be it a complication of pulmonary resection, radiation, or direct tumor mass effect, is associated with high morbidity, impaired quality of life, and an increased risk of death. Incidence of BPF following pneumonectomy ranges between 4.4% and 20% with mortality ranging from 27.2% to 71%. Following lobectomy, incidence ranges from 0.5% to 1.5% in reported series. BPFs are more likely to occur following right-sided pneumonectomy, while patients undergoing bi-lobectomy were more likely to suffer BPF than those undergoing single lobectomy. In addition to supportive care, including appropriate antibiotics and nutrition, management of BPF includes pleural decontamination, BPF closure, and ultimately obliteration of the pleural space. There are surgical and bronchoscopic approaches for the management of BPF. Surgical interventions are best suited for large BPFs, and those occurring in the early postoperative period. Bronchoscopic techniques may be used for smaller BPFs, or when an individual patient is no longer a surgical candidate. Published reports have described the use of polyethylene glycol, fibrin glues, autologous blood products, gel foam, silver nitrate, and stenting among other techniques. The Amplatzer device, used to close atrial septal defects has shown promise as a bronchoscopic therapy. Following their approval under the humanitarian device exemption program for treatment of prolonged air leaks, endobronchial valves have been used for BPF. No bronchoscopic technique is universally applicable, and treatment should be individualized. In this report, we describe two separate cases where we use an Olympus© 21-gauge EBUS-TBNA (endobronchial ultrasound–transbronchial needle aspiration) needle for directed submucosal injection of ethanol leading to closure of the BPF and subsequent successful resolution of PAL.
Small-Molecule Anti-Cancer Drugs From 2016 to 2020: Synthesis and Clinical Application
Authors: Wang Lijiao , Li Rong , Song Chen , Chen Yanli , Long Haiyue , Yang Lingling
Published: September 2021

Malignant tumors have become a significant public health problem that severely threatens human health. Drug-targeting therapy is essential for tumor therapy, along with surgery and radiotherapy. Of the 378 novel drugs approved over the past five years, those for oncological therapy remains at the top (25%). These drugs are used to treat patients with various cancers by acting on corresponding targets, such as EGFR, JAK, BTK, IDH, and FLT3. This review examines anti-tumor agents approved between 2016 and 2020, classifying them according to indication (such as lung cancer, leukemia, breast cancer, and myeloma). These drugs are reviewed according to their route of administration, first-in-class designation, approval dates, and expedited review categories. Furthermore, this paper summarizes the targets and modes of action of the approved anti-tumor drugs while systematically discussing their synthetic routes for medicinal chemistry or industrial use, which will benefit next-generation drug discovery.
Evidence-Based Design for Workplace Violence Prevention in Emergency Departments Utilizing CPTED and Space Syntax Analyses
Authors: El-Hadedy Nada , El-Husseiny Momen
Published: September 2021

Background:

Workplace violence (WPV) is a prevalent phenomenon in Egyptian emergency departments (EDs), an issue that threatens an already scarce resource of healthcare workers. Furthermore, changes and modifications are continuously taking place in hospitals, with no consideration to the important role those changes might play in reducing or encouraging WPV behaviors.

Objective:

This research serves as an initial step in offering answers on how the environmental design of an ED can be modified and manipulated to prevent and control WPV. Accordingly, the objective of this research is to identify the environmental features that potentially influence WPV in the ED. This could provide healthcare designers with the necessary tools to forecast the location of WPV and define the measures needed for a safer working environment.

Method:

The study comprised a hybrid method approach that evaluates the implementation of crime prevention through environmental design (CPTED) through field observation and combined with space syntax analyses (SSAs) of the spatial attributes.

Results:

The results showed a positive relationship between the spatial properties (high integration and connectivity values) and WPV locations. The results also demonstrated that situational factors as natural surveillance played an important role in displacing the WPV locations.

Conclusions:

The contribution of this research lies in elaborating the SSA and CPTED from a conceptual to an empirical level. Combining those tools will help identify the location of WPV in the ED and hence facilitates successful future environmental intervention strategies.
Diffusion of Development Journalism Inside Egyptian Newsrooms
Authors: Allam Rasha , El Gody Ahmed
Published: September 2021

This study examines the boundaries and limitations of the diffusion of “development journalism” among both the editorial body and the journalist body in the Egyptian newsrooms after the 2011 Arab Spring. Newsrooms under study represent different perspectives including state-owned, private-independent, and opposition newspapers. Through in-depth interviews with thirty-seven editors in chief and journalists, the authors studied how the editors and journalists at each newspaper define development journalism, whether the diffusion of development journalism follows a top-down or bottom-up approach, and if development journalism could influence the setting of the news agenda. Results show that the differences are not only apparent in the way development journalism is defined inside the different news organizations, but also between managers and journalists within each. Organizational structures and technological developments are as well factors that affect the way development journalism is diffused inside newsrooms.
Loss of Autophagy Causes Increased Apoptosis of Tibial Plateau Chondrocytes in Guinea Pigs with Spontaneous Osteoarthritis
Authors: Wang Xiao-jian , Tian Wei , Xu Wei-wei , Lu Xiao , Zhang Yu-ming , Li Li-jun , Chang Feng
Published: September 2021

Objective

The goal of the present study was to observe the effect of autophagy in tibial plateau chondrocytes on apoptosis in spontaneous knee osteoarthritis (OA) in guinea pigs.

Design

Fifty 2-month-old female Hartley guinea pigs were divided into a normal group (10 animals, all euthanized after 7 months) and an OA group (40 animals, 10 of which were euthanized after 10 months). Immunohistochemistry, RT-qPCR and Western blotting were used to evaluate autophagy levels, intracellular glycogen accumulation and apoptosis in tibial plateau chondrocytes in vivo and in vitro. The remaining 30 guinea pigs in the OA group were divided into 3 groups: a rapamycin group, a normal saline group, and a 3-methyladenine (3-MA) group. Intracellular glycogen accumulation and chondrocyte apoptosis were assessed by altering the level of autophagy in chondrocytes in vivo.

Results

When spontaneous OA occurred in guinea pigs, autophagy levels in tibial plateau chondrocytes decreased, while intracellular glycogen accumulation and the rate of chondrocyte apoptosis increased. After enhancing the level of autophagy in tibial plateau chondrocytes in guinea pigs with OA, intracellular glycogen accumulation and the rate of chondrocyte apoptosis decreased, while inhibiting autophagy had the opposite effects.

Conclusion

The results indicate that the function of autophagy in chondrocytes may at least partly involve the catabolism of glycogen. In guinea pigs with OA, the level of autophagy in tibial plateau chondrocytes decreased, and chondrocytes were unable to degrade intracellular glycogen into glucose, leading to less energy for chondrocytes and increased apoptosis.
Efficacy and tolerability of infliximab retreatment in patients with inflammatory bowel disease: a systematic review and meta-analysis
Authors: Yang Seungwon , Yang Siyoung , Kwon Jo Young , Kim Seungyeon , Jung Chang Min , Choi Junjeong , Hee Cheon Jae , Yu Yun Mi
Published: September 2021

Background:

A large proportion of patients with inflammatory bowel disease (IBD) relapse after drug discontinuation despite achieving a stable state of infliximab-induced clinical remission. Resuming the use of the same tumor necrosis factor-alpha (TNF-α) inhibitors in patients who relapse following TNF-α inhibitor discontinuation was suggested as a treatment strategy. We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of infliximab retreatment in patients with IBD.

Methods:

A systematic literature search to shortlist relevant studies was conducted using the MEDLINE, Embase, CINAHL, and SCOPUS databases for studies published from inception to August 2020.

Results:

Nine studies were included in the meta-analysis. The pooled clinical remission rate of infliximab retreatment in patients with IBD was 85% (95% confidence interval (CI), 81–89%) for induction treatment and 73% (95% CI, 66–80%) for maintenance treatment. A clinical remission rate following infliximab reintroduction was achieved in a greater proportion of patients with Crohn’s disease (87%; 95% CI, 83–91%) than in those with ulcerative colitis (78%; 95% CI, 61–91%) for induction treatment, but the difference was not statistically significant. Infusion-related reactions after infliximab retreatment occurred in 9% of patients with IBD (95% CI, 3–16%).

Conclusion:

Infliximab retreatment showed high clinical remission rates with tolerable infusion-related reactions in patients with IBD who achieved remission with initial infliximab treatment but relapsed after its discontinuation. We suggest infliximab as a viable alternative in patients with IBD who previously responded well to infliximab treatment.
Setting standards for cystectomy using the British Association of Urological Surgeons Complex Operations Reports, 2016–2018
Authors: John Joseph B , Pascoe John , Fowler Sarah , Rowe Edward , Colquhoun Alexandra , Challacombe Benjamin , Bufacchi Rory , Dickinson Andrew J , McGrath John S
Published: September 2021

Objective:

To produce comprehensive standards for cystectomy using contemporary data collected across a nation.

Patients and methods:

Surgical departments upload cystectomy data to the British Association of Urological Surgeons (BAUS) Complex Operations Database. Analysis of 2016–2018 data was performed for all recorded 5288 patients undergoing cystectomy in England. Logistic regression with general linear models was used to assess differences in patient selection between operative modalities. Analysis involved assessment of case selection, operative decisions and outcomes, case volume and pathological outcomes.

Results:

Using national Hospital Episode Statistics, the BAUS cystectomy dataset was estimated 93% complete. Median age was 70 years (interquartile range 63–75) and 75% were male. Charlson comorbidity index ⩽2 was reported in 87%. Primary treatment of muscle-invasive bladder cancer accounted for 46% of cases. Commonest preoperative disease stages were T2N0 and T1N0 (35% and 25% respectively). Robotic-assisted (RAC), laparoscopic (LC) and open cystectomy (OC) were performed in 41%, 5.5% and 54% of cases respectively. T-stage distribution differed by operative modality. Transfusion rates were 3.7% for RAC, 6.0% for LC and 18% for OC. Increasing positive surgical margin rates were observed with increasing T-stage, up to T3. The conversion-to-open rate for minimally-invasive surgery was 1.7%. Median annual centre and surgeon case volumes were highest for RAC. Median length of stay was 7, 10 and 10 days for RAC, LC and OC respectively. Postoperative histological upstaging was common (33% of cT1, 50% of cT2 cases). Lymph node positive rates were 28% for muscle-invasive bladder cancer.

Conclusion:

Analysis of this data provides understanding of ‘real-world’ cystectomy practice. Presentation of data specific to operative modality allows surgeons and centres to benchmark their respective practices. These findings offer to enhance patient and public understanding beyond that currently facilitated by publicly-facing information sources. They carry relevance by describing a near-complete and large volume of modern practice in a publicly funded healthcare system.

Level of evidence:

2b
Concomitant carcinoma in situ is an independent prognostic predictor for patients with localized lymph node–negative upper-tract urothelial carcinoma undergoing nephroureterectomy
Authors: Cheng Pai-Yu , Chung Shiu-Dong , Tsai Chung-You
Published: September 2021

Purpose:

This study aimed to determine the predictive value of concomitant carcinoma in situ (CIS) for cancer-specific survival (CSS) in patients with upper-tract urothelial carcinoma (UTUC) undergoing radical nephroureterectomy.

Methods:

This was a retrospective analysis of the clinicopathological features in a cohort of 126 patients with localized lymph node–negative UTUC who underwent radical nephroureterectomy with bladder-cuff excision in a tertiary medical center between January 1, 2007, and June 30, 2018. Cox proportional hazards models were used to identify risk factors for CSS in UTUC. Additionally, Kaplan–Meier analyses were performed in subgroups according to pathological tumor stage.

Results:

The median age and follow-up duration were 70 years and 3.5 years, respectively. Concomitant CIS, which was present in 21% of the patient specimens, was not associated with most clinical or pathological features, except for lymphovascular invasion and multifocality. Concomitant CIS (adjusted hazard ratio (HR)=4.64, 95% confidence interval (CI) 1.78–12.06, p=0.002) and pathological tumor stage (adjusted HR=4.07, 95% CI 1.99–8.31, p<0.001) were significantly associated with CSS in the multivariate Cox regression model. In the subgroup analysis, concomitant CIS in patients with locally advanced (pT3/pT4) UTUC was associated with significantly worse CSS compared to those without CIS (HR=3.83, 95% CI 1.20–12.21).

Conclusion:

The pathological presence of concomitant CIS was independently associated with poor CSS in patients with localized lymph node–negative UTUC undergoing radical nephroureterectomy. These findings provide crucial information relevant for postoperative patient counseling, use of adjuvant therapy, follow-up intensity, and clinical trial enrollment.

Level of evidence

Level II.
Computational challenges to test and revitalize Claude Lévi-Strauss transformational methodology
Authors: Doja Albert , Capocchi Laurent , Santucci Jean-François
Published: September 2021

The ambition and proposal for data modeling of myths presented in this paper is to link contemporary technical affordances to some canonical projects developed in structural anthropology. To articulate the theoretical promise and innovation of this proposal, we present a discrete-event system specification modeling and simulation approach in order to perform a generative analysis and a dynamic visualization of selected narratives, aimed at validating and revitalizing the transformational and morphodynamic theory and methodology proposed by Claude Lévi-Strauss in his structural analysis of myth. After an analysis of Lévi-Strauss’s transformational methodology, we describe in detail how discrete-event system specification models are implemented and developed in the framework of a DEVSimPy software environment. The validation of the method involves a discrete-event system specification simulation based on the extension of discrete-event system specification models dedicated to provide a dynamic Google Earth visualization of the selected myth. Future work around the discrete-event system specification formalism in anthropology is described as well as future applications regarding the impact of computational models (discrete-event system specification formalism, Bayesian inferences, and object-oriented features) to new contemporary anthropological domains.
Facebook News Sharing, Hostile Perceptions of News Content, and Political Participation
Authors: Kim Mihee
Published: September 2021

This study explored Facebook users’ hostile perceptions of shared news content and its relationship with their political participation. This study conducted an online experiment with a 3 (news slant: pro-attitudinal, neutral, counter-attitudinal) × 3 (news sharer: in-group, neutral, out-group) between-subjects design. This experiment was administered in the context of the abortion issue in South Korea. Consistent with the hostile media effect, the news slant (pro-attitudinal, counter-attitudinal) of shared news content was found to influence Facebook users’ hostile perceptions of shared news content. Out-group sharers also significantly affected their hostile perceptions of shared news content. However, in-group sharers did not. Furthermore, the effect of Facebook users’ hostile perceptions of shared news content on their willingness for political participation was moderated by their prior minority perception in the general society. Only for Facebook users with high levels of prior minority perception in the general society, their hostile perceptions of shared news content appeared to encourage their political engagement. The implications of these findings were discussed.
Lived Experiences of Women Receiving Medical Treatments for Breast Cancer in Ghana: A Qualitative Study
Authors: Kugbey Nuworza , Meyer-Weitz Anna , Oppong Asante Kwaku , Yarney Joel , Vanderpuye Verna
Published: September 2021

Breast cancer diagnosis and its treatment present women with significant challenges which require adjustment in several domains to ensure good health outcomes. Any psychosocial interventions to address the challenges need to be informed by empirical evidence. However, there is dearth of empirical literature in this regard in the Ghanaian context. To address some of these gaps, we explored the lived experiences of women living with breast in Ghana to inform healthcare practice and breast cancer research. In-depth individual interviews were conducted among 11 breast cancer patients receiving medical treatment for breast cancer. The interpretative phenomenological approach was used in the data analysis. Findings from the study showed that participants’ lived experiences cluster around three major themes; burdens of breast cancer treatments, alternative/herbal medicine use, and breast cancer stigma. These findings underscore the need for a multidisciplinary treatment approach to achieve optimum health outcomes among these groups of women.