bluuebunny/crossref_metadata_2025 huggingface dataset:
An Overview of the Latest Applications of Platelet-Derived
Microparticles and Nanoparticles in Medical Technology 2010-2020
Authors: Mehrizi Tahereh Zadeh
Published: October 2021

:

Today, Platelets and platelet-derived nanoparticles and microparticles have
found many applications in nanomedical technology. The results of our review study
show that no article has been published in this field to review the current status of
applications of these platelet derivatives so far. Therefore, in the present study, our goal
is to compare the applications of platelet derivatives and review their latest status
between 2010 and 2020 to present the latest findings to researchers. A very interesting
point about the role of platelet derivatives is the presence of molecules on their surface,
which makes them capable of hiding from the immune system, reaching different target
cells, and specifically attaching to different cell types. According to the results of this
study, most of their applications include drug delivery, diagnosis of various diseases,
and tissue engineering. However, their application in drug delivery is limited due to
heterogeneity, large size, and the possibility of interference with cellular pathways in
microparticles derived from other cells. On the other hand, platelet nanoparticles are
more controllable and have been widely used for drug delivery in the treatment of
cancer, atherosclerosis, thrombosis, infectious diseases, repair of damaged tissue, and
photothermal therapy. The results of this study show that platelet nanoparticles are more
controllable than platelet microparticles and have a higher potential for use in medicine.
Activated Pancreatic Stellate Cells Promote Acinar Duct Metaplasia by
Disrupting Mitochondrial Respiration and Releasing Reactive Oxygen
Species
Authors: Xiang Hong , Guo Fangyue , Zhou Qi , Tao Xufeng , Dong Deshi
Published: October 2021

Background:

Chronic Pancreatitis (CP) is a long-term risk factor for pancreatic ductal
adenocarcinoma (PDAC), and both diseases share a common etiology. The activation of
Pancreatic stellate cells (PaSCs) caused by inflammation of the chronic pancreas plays a pivotal
role in the pathology of pancreatic fibrosis and the malignant phenotype of PDAC. However, the
central role of activated PaSCs in Acinar-to-Ductal Metaplasia (ADM) remains unknown.

Objective:

In the present study, we investigated the link between pancreatic fibrosis and ADM
and the possible underlying mechanism.

Methods:

A caerulein-treated mouse CP model was established, and Masson trichrome histochemical
stain and Transmission Electron Microscope (TEM) were used to observe stromal fibrosis
and cell ultrastructure, respectively. The expression of amylase and cytokeratin 19
(CK19), mitochondria respiration, and reactive oxygen species (ROS) were detected in vitro in
the co-culture model of primary pancreatic acinar cells and PaSCs.

Results:

The activation of PaSCs and pancreatic fibrosis were accompanied by ADM in pancreatic
parenchyma in caerulein-treated mice, which was verified by the co-cultivation experiment
in vitro. Furthermore, we showed that activated PaSCs promote ADM by disrupting mitochondrial
respiration and releasing ROS. The expression of inflammation-and ADM-related genes,
including S100A8, S100A9, and CK19, was observed to be up-regulated in pancreatic acinar
cells in the presence of activated PaSCs. The expression of S100A9 and CK19 proteins was also
up-regulated in acinar cells co-cultured with activated PaSCs.

Conclusion:

The manipulation of mitochondrial respiration and ROS release is a promising preventive
and/or therapeutic strategy for PDAC, and S100A9 is expected to be a therapeutic target
to block the ADM process induced by the activation of PaSCs.
Comparison of Two Control Strategies for VSC-MTDC with Wind Farm
Authors: Li Congshan , Zhong Pu , He Ping , Liu Yan , Fang Yan , Sheng Tingyu
Published: October 2021

:

Two VSC-MTDC control strategies with different combinations of controllers are proposed
to eliminate transient fluctuations in the DC voltage stability, resulting from a power imbalance
in a VSC-MTDC connected to wind farms. First, an analysis is performed of a topological
model of a VSC converter station and a VSC-MTDC, as well as of a mathematical model of a wind
turbine. Then, the principles and characteristics of DC voltage slope control, constant active power
control, and inner loop current control used in the VSC-MTDC are introduced. Finally, the
PSCAD/EMTDC platform is used to establish an electromagnetic transient model of a wind farm
connected to a parallel three-terminal VSC-HVDC. An analysis is performed for three cases of single-
phase grounding faults on the rectifier and inverter sides of a converter station and of the withdrawal
of the converter station on the rectifier side. Next, the fault response characteristics of VSCMTDC
are compared and analyzed. The simulation results verify the effectiveness of the two control
strategies, both of which enable the system to maintain DC voltage stability and active power
balance in the event of a fault.

Background:

The use of a VSC-MTDC to connect wind power to the grid has attracted considerable
attention in recent years. A suitable VSC-MTDC control method can enable the stable operation
of a power grid.

Objective:

The study aims to eliminate transient fluctuations in the DC voltage stability resulting
from a power imbalance in a VSC-MTDC connected to a wind farm.

Methods:

First, the topological structure and a model of a three-terminal VSC-HVDC system connected
to wind farms are studied. Second, an analysis is performed of the outer loop DC voltage
slope control, constant active power control and inner loop current control of the converter station of
a VSC-MTDC. Two different control strategies are proposed for the parallel three-terminal VSCHVDC
system: the first is DC voltage slope control for the rectifier station and constant active power
control for the inverter station, and the second is DC voltage slope control for the inverter station
and constant active power for the rectifier station. Finally, a parallel three-terminal VSC-HVDC
model is built based on the PSCAD/EMTDC platform and used to verify the accuracy and effectiveness
of the proposed control strategy.

Results:

The results of simulation analysis of the faults on the rectifier and inverter sides of the system
show that both strategies can restore the system to the stable operation. The effectiveness of the
proposed control strategy is thus verified.

Conclusion:

The control strategy proposed in this paper provides a technical reference for designing
a VSC-MTDC system for wind farms.
Exploration of Physicochemical Parameters of Natural Origin Polymers
Authors: Bidikar Chaitrali M. , Inamdar Poonam R
Published: October 2021

Background:

Natural polymers are fascinating category of small chain molecules originating
from natural resources, and few examples include Sodium Alginate and Xanthan Gum
which are water-soluble in nature; used for mainly food packaging, biomedical and pharmaceutical
applications. In the proposed research work, an effort was made to overcome the polymer challenges
emerging from the development of polymer blends, as the miscibility between polymers is a
vital aspect.

Objective:

This work focuses on the miscibility studies of natural origin polymers. In regards to
that, Sodium Alginate/ Xanthan Gum blends were prepared in variable concentrations in aqueous
medium and it was utilized for viscosity analysis, FTIR, Ultraviolet spectroscopic studies at variable
temperatures.

Methods:

It was observed that the developed Sodium Alginate / Xanthan Gum blends are miscible
with each other at most of the temperatures (at 20°C, 40°C and 60°C) considering their viscosity
parameters, FTIR and UV spectral data.

Results:

Viscosity studies revealed that the miscibility windows of polymeric ratio increases as the
temperature increases whereas FTIR spectral patterns exhibited that the composition having 60:40
ratio of polymers exhibits high intensity stretches and represented to be miscible when compared to
other combinations.

Conclusion:

The present study has reported the simple and efficient method in exploration of the
miscibility windows of Sodium alginate and Xanthan gum blend.
Simulasi Gaya Pemotongan pada Proses Bubut dengan Software Third Wave Advantedge
Authors:   Universitas Jember, Qoryah Rika Dwi Hidayatul , Sari Herninda Ayu Meylinda , Darsin Mahros , Mulyadi Santoso
Published: October 2021

The cutting force that reacts to cutting tool and workpieces will result deflection. Deflection is the cause of product deviation and vibration sources that can shorten the life of the cutting tool. Simulation of machining process is carried out to get an estimate of cutting force in some machining process conditions., then compare it to the experiments. The research aims to find out the influence of spindle rotary speed, feed rate and depth of cut on cutting forces in turning process with cutting tool HSS and workpiece Al 6061. This research uses three-dimensional simulation method using Third Wave AdvantEdge software. Following by comparison between the simulation with the experiments results. The simulation was in accordance to the experiments in term of the magnitude of the forces, from the biggest they are tangential, axial, and radial force respectively. Cutting force will decrease with increased spindle turning speed. Cutting force will increase with the rising feed rate and depth of cut. However, the simalution still highly deviate from the experiments at the rate of 71%, 44.3%, and 21.3% for axial, radial and tangential forces respectively. The possible cause of these high errors relates to forces measuring method in experiments.
Analisis Kinerja Pompa Sentrifugal pada Variasi Trim Diameter Menggunakan Simulasi Numerik
Authors:   Universitas Gajah Mada, Waluyo Joko , Mahardhika Kevin , Waluyo Rahmat
Published: October 2021

Diameter trimming is one of the most common modification on centrifugal pump impeller aimed to keep conformity between pump performance and required head and flow rate. In its application, centrifugal pump performance with trimmed diameter could be predicted by using affinity equations which based on geometrical similarity between pre- and post-trimming impeller. However, diameter trimming also alter the dimension ratio in blade passage which prompt further investigation on performance prediction of pump with trimmed impeller diameter. This research is carried out by using numerical simulation to analyze performance of pump with trimmed impeller diameter. The simulation is conducted on radial-type centrifugal pump with impeller diameter 105 mm, inlet blade angle 200, outlet blade angle 280, and operating on mass flow rate 1.5 kg/s at rotational speed 2800 rpm. RNG k-e model is used to model turbulence while trimmed diameter values are 100 mm and 95 mm. Results indicate that there is significant differences on head and consumed power between predicted value by simulation and predicted value obtained by employing affinity equations.
The Effect of Mass and Diameter of Waste Valves on the Efficiency of 3 inch Ram Hydraulic
Authors:   Universitas Nusa Cendana, Jafri Muhamad , Sanusi Arifin , Wangge Gusti F.X. Wara
Published: October 2021

This study aim to analyze the effect of the mass and diameter of the waste valve on the efficiency of hydraulic pumps. This study method was an experiment on the specimens and analyzing the mathematical equations contained in the hydraulic pump theory. The data measured in this study were the flow of water in, discharge of wastewater, and discharge of water out. Independent variables in this study were the mass of the waste valve, namely 1.5 kg, 2.0 kg, 2.5 kg, 3.0 kg and the diameter of the waste valve was 2.0 inches, 2.25 inches, and 2.50 inches. While the dependent variable were the discharge and efficiency of the hydraulic pump. The results show that the mass of the waste valve and the diameter of the waste valve affected the efficiency of the hydraulic pump. The highest efficiency of the hydraulic pump occurred at a waste valve mass of 1.5 kg and a waste valve diameter of 2.5 inches which was 78.08%, and the lowest efficiency occurred at a mass of 3.0 kg waste valve and a 2.0-inch diameter of a waste valve which was 33. 56%.
Pengembangan Alat Bantu Arbor untuk Pembuatan Roda Gigi pada Mesin Frais Vertikal
Authors:   Politeknik Negeri Batam, Widodo Widodo , Hakim Rahman
Published: October 2021

The machining process is included in the classification of metal cutting processes, which are used to change the shape of metal or non-metallic product by cutting, peeling or separating. One of the machines used in this cutting process is a vertical type milling machine. This machine functions to make a product, one of which was a gear. The supporting equipment needed to make this gear was a vertical arbor tool. The material used in the manufacture of this product was a cast carbon steel type using the design method for manufacturing and assembly (DFMA), which began by examining and identifying needs, conceptualizing and designing products and making these products tailored to the dimensional specifications of standard and common cutter modules in the market. The results of the manufacture of this tool were directly tested for the manufacture of gears of various sizes and produced products whose deviations were within the tolerance of the measuring instrument, namely in the range 0 to 2%. In addition, the von Mises stress simulation at an engine speed of 150 Rpm, 450 Rpm and 750 Rpm and the resulting maximum stress was still below the yield limit, so it was safe to use.
PENGELOLAAN DESA WISATA BERBASIS PARTISIPASI MASYARAKAT LOKAL DI NEGERI SALEMAN KABUPATEN MALUKU TENGAH
Authors:   Program Studi Perencanaan WIlayah dan Kota, Universitas Teknologi Yogyakarta, Romeon Rachmat , Sukmawati Annisa
Published: October 2021

Negeri Saleman merupakan salah satu wilayah yang terletak di Desa Sawai, Kecamatan Seram Utara, Kabupaten Maluku Tengah, Provinsi Maluku yang memiliki beragam potensi alam berupa wisata pantai dan wisata bahari. Namun, wisata di Negeri Saleman belum terkelola dengan baik karena masih terbatasnya keterlibatan pemerintah daerah. Wisata-wisata yang ada masih dikelola secara mandiri oleh masyarakat setempat. Untuk itu, penelitian bertujuan untuk menggali bentuk-bentuk partisipasi masyarakat lokal dalam pengelolaan potensi wisata di Negeri Saleman. Penelitian menggunakan metode penelitian kualitatif dengan teknik analisis deskriptif kualitatif. Pengumpulan data dilakukan dengan observasi lapangan, wawancara mendalam dengan teknik purposive sampling kepada 7 informan, dan telaah dokumen. Hasil penelitian menunjukan bahwa bentuk partisipasi masyarakat lokal Negeri Saleman adalah sebagai pelaku utama pariwisata, seperti penyedia jasa akomodasi wisata dan oleh-oleh khas Negeri Saleman. Selain itu, ada juga peran dari local champion, yaitu tokoh adat dan Bapa Raja yang berperan sebagai pengawas dan pengendali aktivitas wisata agar keberlanjutan aktivitas wisata dapat terjamin. Faktor yang mendorong keterlibatan masyarakat lokal adalah motif ekonomi terkait dampak ekonomi wisata terhadap peningkatan taraf hidup masyarakat setempat.
Tingkat Produktivitas Pada Aglomerasi Industri (Studi Kasus : Sentra Industri Mebel Tunjungsekar, Kota Malang)
Authors:   Perencanaan Wilayah dan Kota Universitas Brawijaya, Ashary Dinar , Wijayanti Wawargita , Dinanti Dian
Published: October 2021

Industri pengolahan non migas menjadi salah satu pilar perekonomian masyarakat Indonesia salah satunya adalah sektor Industri Kecil dan Menengah (IKM), IKM mampu menyerap tenaga kerja lebih dari 60% dari sektor industri, memiliki ketahanan akan kiris ekonomi dan juga berperan dalam ekonomi lokal, karena penyerapan tenaga kerja yang memanfaatkan masyarakat di sekitarnya. Industri pengolahan kayu menjadi salah satu industri yang berkembang pesat namun memiliki permasalahan terhadap ketersediaan bahan baku. Agar industri dapat terus berkompetisi salah satu strategi untuk efisiensi produksi dengan memanfaatkan industri yang beraglomerasi. Aglomerasi ini biasanya memunculkan manfaat ekonomi berupa limpahan tenaga kerja, kerja sama suplier khusus, terjadinya transfer pengetahuan dan teknologi, serta kerja sama pemasaran. Salah satu aglomerasi industri di Kota Malang ialah Industri Mebel Tunjungsekar. Produktivitas sentra industri mebel ini mengalami rintangan terutama pada persediaan bahan baku kayu dan tenaga kerja yang masih mengandalkan kekerabatan, selain itu ini belum didukung kelembagaan yang baik serta belum ada jaringan pemasaran yang kuat. Maka penelitian ini bertujuan untuk melihat bagaimana tingkat produktivitas sentra indutri mebel sebagai salah satu bentuk terjadinya aglomerasi menggunakan rumus produktivitas yaitu perbandingan nilai total output/ pendapatan dengan nilai total input/ pengeluaran (biaya tenaga kerja, modal dan bahan baku) di tahun 2019. Hasil analisis menunjukkan bahwa ke-30 industri mebel memiliki nilai di atas 1,0 dengan rata-rata nilai 1,31. Nilai produktivitas yang tidak jauh di atas 1,00 dikarenakan masih terdapat permasalahan pada tingginya biaya bahan baku dan modal namun tidak diimbangi dengan tingginya jumlah pesanan produk mebel yang terjual.
Структура и фазовый состав пленок, полученных методом лазерного спекания из поливинилиденфторида различных марок
Authors: Тарасова Е.Ю. , Журавлева И.И. , Бакулин И.А. , Кузнецов С.И. , Панин А.С.
Published: October 2021

The processes of laser synthesis of films with a thickness of 80-230 µm from polyvinylidene fluoride of various grades are studied. It is established that the range of synthesis modes does not depend on the grades of PVDF. The content of the piezo active β-phase decreases after laser treatment, but the complete transformation of β→α does not occur. The process of thermos-oxidative degradation after laser treatment is not observed. Under the same treatment conditions, the higher the open porosity coefficient, the lower the polymer melt flow index (MFI). Depending on the MFI of the initial polymer, the selection of laser exposure modes can control the porosity of the films in the range of 26-68 %.
Эффективная диэлектрическая проницаемость анизотропного композита из сфероидных частиц в диэлектрической матрице
Authors: Беляев Б.А. , Тюрнев В.В. , Ходенков С.А.
Published: October 2021

The concentration dependences of the effective permittivity of an anisotropic composite containing co-directional particles in the form of oblate or elongated ellipsoids of rotation – spheroids – in the dielectric matrix are obtained. The calculation is made by the numerical solution of a system of coupled quadratic and integral equations obtained by a strict modification of the quasi-static Bruggeman theory. It is shown that the traditional (simplified) modification of the Bruggeman theory, widely used for calculating anisotropic composites, gives errors of different signs for the longitudinal and transverse polarization of electromagnetic waves relative to the axis of spheroids. In this case, the dependences of errors on the concentration of particles are non-monotonic, and the extremes observed on them can exceed 100%. Moreover, the position and magnitude of the extremes strongly depend on the ellipticity of the particles, as well as on the contrast of their permittivity with the matrix.
Экспериментальное исследование процессов теплопереноса в тонкопленочных структурах на основе перовскитов методом низкокогерентной тандемной интерферометрии
Authors: Травкин В.В. , Коптяев А.И. , Пахомов Г.Л. , Волков П.В. , Семиков Д.А. , Лукьянов А.Ю.
Published: October 2021

The heat transfer in an archetypal system ‘solar cell/environment’ was analyzed, in which the solar cell was a thin-film multilayer structure with a hybrid lead-iodide perovskite photoabsorber. The temperature field was mathematically modeled and heat maps of the cell at various irradiation intensities were calculated. It was found that the heating of the structure by a diffuse insolation has a maximum at about half of the overall thickness, but it does not exceed the threshold critical for the stability of the perovskite phase owing to dissipation into the environment.
Формирование текстуры (100) в тонких пленках Ti под действием низкоэнергетической ионной бомбардировки
Authors: Селюков Р.В. , Изюмов М.О. , Наумов В.В. , Мазалецкий Л.А.
Published: October 2021

10-40 nm Ti films with mixed crystalline texture (100)+(001) are exposed to ion bombardment in inductively coupled Ar plasma by applying the bias -30 V to the films. It is found that such a treatment leads to the formation of (100) texture in films. This result is explained by the generation of the compressive stress in films as a result of ion bombardment. The thinner the film the less time is required to form the (100) texture.
Medical Needs Extraction for Breast Cancer Patients from Question and Answer Services: Natural Language Processing-Based Approach
Authors: Kamba Masaru , Manabe Masae , Wakamiya Shoko , Yada Shuntaro , Aramaki Eiji , Odani Satomi , Miyashiro Isao
Published: October 2021

Background

A large number of patient narratives are available on various web services. As for web question and answer services, patient questions often relate to medical needs, and we expect these questions to provide clues for a better understanding of patients’ medical needs.

Objective

This study aimed to extract patients’ needs and classify them into thematic categories. Clarifying patient needs is the first step in solving social issues that patients with cancer encounter.

Methods

For this study, we used patient question texts containing the key phrase “breast cancer,“ available at the Yahoo! Japan question and answer service, Yahoo! Chiebukuro, which contains over 60,000 questions on cancer. First, we converted the question text into a vector representation. Next, the relevance between patient needs and existing cancer needs categories was calculated based on cosine similarity.

Results

The proportion of correct classifications in our proposed method was approximately 70%. Considering the results of classifying questions, we found the variation and the number of needs.

Conclusions

We created 3 corpora to classify the problems of patients with cancer. The proposed method was able to classify the problems considering the question text. Moreover, as an application example, the question text that included the side effect signaling of drugs and the unmet needs of cancer patients could be extracted. Revealing these needs is important to fulfill the medical needs of patients with cancer.
The Effect of Cardiovascular Comorbidities on Women Compared to Men: Longitudinal Retrospective Analysis (Preprint)
Authors: Dervic Elma , Deischinger Carola , Haug Nils , Leutner Michael , Kautzky-Willer Alexandra , Klimek Peter
Published: October 2021

BACKGROUND

Although men are more prone to developing cardiovascular disease (CVD) than women, risk factors for CVD, such as nicotine abuse and diabetes mellitus, have been shown to be more detrimental in women than in men.

OBJECTIVE

We developed a method to systematically investigate population-wide electronic health records for all possible associations between risk factors for CVD and other diagnoses. The developed structured approach allows an exploratory and comprehensive screening of all possible comorbidities of CVD, which are more connected to CVD in either men or women.

METHODS

Based on a population-wide medical claims dataset comprising 44 million records of inpatient stays in Austria from 2003 to 2014, we determined comorbidities of acute myocardial infarction (AMI; International Classification of Diseases, Tenth Revision [ICD-10] code I21) and chronic ischemic heart disease (CHD; ICD-10 code I25) with a significantly different prevalence in men and women. We introduced a measure of sex difference as a measure of differences in logarithmic odds ratios (ORs) between male and female patients in units of pooled standard errors.

RESULTS

Except for lipid metabolism disorders (OR for females [ORf]=6.68, 95% confidence interval [CI]=6.57-6.79, OR for males [ORm]=8.31, 95% CI=8.21-8.41), all identified comorbidities were more likely to be associated with AMI and CHD in females than in males: nicotine dependence (ORf=6.16, 95% CI=5.96-6.36, ORm=4.43, 95% CI=4.35-4.5), diabetes mellitus (ORf=3.52, 95% CI=3.45-3.59, ORm=3.13, 95% CI=3.07-3.19), obesity (ORf=3.64, 95% CI=3.56-3.72, ORm=3.33, 95% CI=3.27-3.39), renal disorders (ORf=4.27, 95% CI=4.11-4.44, ORm=3.74, 95% CI=3.67-3.81), asthma (ORf=2.09, 95% CI=1.96-2.23, ORm=1.59, 95% CI=1.5-1.68), and COPD (ORf=2.09, 95% CI 1.96-2.23, ORm=1.59, 95% CI 1.5-1.68). Similar results could be observed for AMI.

CONCLUSIONS

Although AMI and CHD are more prevalent in men, women appear to be more affected by certain comorbidities of AMI and CHD in their risk for developing CVD.
Comparison of Online Patient Reviews and National Pharmacovigilance Data for Tramadol-Related Adverse Events: Comparative Observational Study (Preprint)
Authors: Park Susan , Choi So Hyun , Song Yun-Kyoung , Kwon Jin-Won
Published: October 2021

BACKGROUND

Tramadol is known to cause fewer adverse events (AEs) than other opioids. However, recent research has raised concerns about various safety issues.

OBJECTIVE

We aimed to explore these new AEs related to tramadol using social media and conventional pharmacovigilance data.

METHODS

This study used 2 data sets, 1 from patients’ drug reviews on WebMD (January 2007 to January 2021) and 1 from the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS; January 2016 to December 2020). We analyzed 2062 and 29,350 patient reports from WebMD and FAERS, respectively. Patient posts on WebMD were manually assigned the preferred terms of the Medical Dictionary for Regulatory Activities. To analyze AEs from FAERS, a disproportionality analysis was performed with 3 measures: proportional reporting ratio, reporting odds ratio, and information component.

RESULTS

From the 869 AEs reported, we identified 125 new signals related to tramadol use not listed on the drug label that satisﬁed all 3 signal detection criteria. In addition, 20 serious AEs were selected from new signals. Among new serious AEs, vascular disorders had the largest signal detection criteria value. Based on the disproportionality analysis and patients’ symptom descriptions, tramadol-induced pain might also be an unexpected AE.

CONCLUSIONS

This study detected several novel signals related to tramadol use, suggesting newly identified possible AEs. Additionally, this study indicates that unexpected AEs can be detected using social media analysis alongside traditional pharmacovigilance data.
An Ambient Assisted Living platform for supporting aging in place of pre-frail and frail older adults: Rationale, HomeAssist plaform, quasi-experimental design, and baseline characteristics. (Preprint)
Authors: sauzeon helene , Edjolo Arlette , Amieva Hélène , Consel Charles , Pérès Karine
Published: October 2021

UNSTRUCTURED

Background: Ambient Assisted Living (AAL) technology is expected as a promising way for prolonging the aging in place. Very few evidence-based results are provided support to its real value, notably for frail older adults who have high risk of autonomy loss and of entering in nursing home.

Objective: HomeAssist (HA) is a human-centered AAL platform offering a large set of applications for three main age-related need domains (Activities of Daily Living, Safety and Social participation), relying on a basic set of entities (sensors, actuators...). The HA intervention involves monitoring as well as assistive services to support independent living at home. The primary outcomes measures are related to aging in place in terms of effectiveness (institutionalization and hospitalization rates) and efficiency (everyday functioning indices). Secondary outcomes measures include indices of frailty, cognitive functioning, and psychosocial health of participants and their caregivers. Every 6 months, user experience and attitudes towards HA are also collected in equipped participants. Concomitantly, HA usages are collected.

Methods: A study assessing the HA efficacy has been designed and is now conducted with 131 older adults aged 81.9 (±6.0) years (from autonomous to frail) who lived alone. The study design is quasi-experimental with a duration of 12 months optionally extensible to 24 months. It includes equipped participants, matched with non-equipped participants (n= 474). Follow-up assessments occurred at 0, 12 and 24 months.

Results: The expected results are to inform the AAL value for independent living, but also to yield informed analysis on AAL usages and adoption in frail older individuals.
From the Cochrane Library: Topical Treatments for Cutaneous Warts (Preprint)
Authors: Oganesyan Ani , Sivesind Torunn , Dellavalle Robert
Published: October 2021

UNSTRUCTURED

N/A
Efficacy of an online intervention for treatment of depressive disorders: a three-arm randomized controlled trial comparing guided and unguided self-help with waitlist control (Preprint)
Authors: Rico Krämer
Published: October 2021

BACKGROUND

Digital health applications are efficacious treatment options for mild-to-moderate depressive disorders. However, the extent to which psychological guidance increases the efficacy of these applications is controversial.

OBJECTIVE

We evaluated the efficacy of the online intervention “Selfapy” for unipolar depression. We also investigated differences between a psychotherapist-guided vs. unguided version compared with those from a control group.

METHODS

A cohort of 401 participants with mild-to-severe depressive disorders were assigned randomly to either participate in a guided version of Selfapy (involving weekly telephone calls of 25-min duration), an unguided version of Selfapy, or to the waiting list (control group). Selfapy is a cognitive behavioral therapy-based intervention for depressive disorders of duration 12 weeks. Symptom assessment was undertaken at T1 (before study entrance), T2 (after 6 weeks), T3 (post-treatment, after 12 weeks), and T4 (follow-up, after 6 months). The main outcome was reduction in depressive symptoms in the Beck Depression Inventory (BDI-II) from T1 to T3. Secondary-outcome parameters were the Quick Inventory of Depressive Symptomatology – Self Report (QIDS-SR 16) and Beck Anxiety Inventory (BAI).

RESULTS

A total of 297 out of 401 participants (74.06%) completed the post-measurement at T3. In the primary analysis, both intervention groups showed a significantly higher reduction in depressive symptoms (BDI-II) from T1 to T3 compared with that in the control group, with high within-effect sizes (guided: d = 1.46; unguided d = 1.36). No significant differences were found for guided vs. unguided treatment groups. The response rate (BDI-II) for intention-to-treat data in the guided version was 46.4%, 40.0% for the unguided version, and 2.0% in the control group. After 6 months (T4), treatment effects could been maintained for both intervention groups (BDI-II) without differences between either intervention group.

CONCLUSIONS

Conclusions: Selfapy can help to reduce depressive symptoms in guided or unguided version. Follow-up data suggest that these effects could be maintained. The guided version was not superior to the unguided version.

CLINICALTRIAL

Trial Registration: Current Controlled Trial DRKS00017191
Date of registration: 14 May 2019

INTERNATIONAL REGISTERED REPORT

RR2-https://doi.org/10.1186/s13063-021-05218-4
Antibacterial (Staphylococcus aureus and Escherichia coli) and Antifungal (Saccharomyces cerevisiae) Activity Assay on Nanoemulsion Formulation of Ethanol Extract of Mangosteen Leaves (Garcinia mangostana L.) as Fruit Preservative
Authors: Diniatik Diniatik , Anggraeni Rosiana Sofia
Published: October 2021

Fruits after harvesting will decay faster if not handled properly. Fruits can be demaged by bacterial and fungal. Mangosteen leaves contain xanthons which are antibacterial and antifungal. 50% ethanol extract of mangosteen leaves is formulated in Nanoemulsion preparations using the SNEDDS (Self-Nanoemulsifying Drug Delivery System) method. The mangosteen leaves 50% ethanol extract nanoemulsion formulation consisted of VCO (Virgin Coconut Oil) as oil, tween 80 as surfactant, and PEG 400 as cosurfactant. There are 3 formulations with variations in the concentration of mangosteen leaves ethanol extract, there are concentrations of 1%, 2%, and 3%. All formulations have a T% of more than 90%. The results of the particles measurement of nanoemulsion using PSA were in formulation 1 amounting to 16.1 nm; formula 2 is 16.7 nm; and formula 3 is 16.6 nm. The zeta potential characterization shows that formula 1 has a zeta value of -40.9 mV. The three formulations had a pH of 5. The largest inhibitory zone in the mangosteen leaf ethanol extract against S.aureus and E. coli bacteria were 11.08 mm and 5.87 mm respectively. Whereas in the S. cerevisiae antifungal test there was no inhibition zone at all concentrations. In the antibacterial and antifungal tests nanoemulsion preparations did not produce inhibitory zones in each concentration. Nanoemulsion preparations can retain the quality of strawberries when compared to the non-nanoemulsion preservative group, both in room storage and refrigerator temperature. The best preservative result is when the fruit is coated with nanoemulsion preservative and stored in refrigerator temperature.
Exploring the Antimicrobial Activities of Chrysophyllum albidum Seed oil in Pharmaceutical and the Seeds in Food industry.
Authors: Olabanji Iyabo Oluremi , Akinkunmi Emmanuel Olugbenga , O Nancy Aniki , Arowosegbe Sunday Michael , Ajayi Olukayode Solomon , Yoade Reuben , Fasesan Funmilola
Published: October 2021

The anti- microbial activity tests of the seed oil, NaOH and ash soaps of the seed oil, of C.albidum were carried out to determine their effectiveness against gram+, gram– bacteria and some fungi strains. The proximate analysis of C.albidum seeds was performed to determine its nutritional benefits to mankind. Agar diffusion tests using Disc diffusion for the pure oils and soaps while the cup plate test method for dilutions was used in the determination of in-vitro activities. Standard methods as described by AOAC, (1990); AOAC, (1984) and Kjeldahl method described by Chang (2003) were used for proximate determinations. The results show the activity of the oil against Klebsiella pneumonia at a concentration as low as 10 mg/ml. The ash-soap of the leaves shows the highest antimicrobial activities because its MIC is the closest to the standard, Streptomycin. It possesses activity against Escherichia coli and Klebsiella pneumonia at a concentration as low as 5mg/ml. The % proximate analysis composition shows Moisture content, Ash content, Crude Fibre, fat/Oil, Protein, Carbohydrates as follows (14.98, 1.90, 2.09, 2.38, 12.14 and 67.65)%. The study concluded by unleashing the great potential of Chrysophyllum albidum seeds as a useful raw material in food, cosmetics and pharmaceutical industries rather than being regarded as waste in the environment
A Simple Liquid-Liquid Fractionation (LLF) Method for Isolating Deoxyandrographolide dan Andrographolide from Herbs of Andrographis paniculata (Burm., F) Ness and Its Cytotoxic Activity on 3T3-L1 Preadipocyte Cells
Authors: Novitasari Putri Rachma , Astuti Novia Tri , Pramono Suwijiyo , Tjandrawinata Raymond , Nugroho Agung Endro
Published: October 2021

The main bitter constituents of sambiloto (Androgaphis paniculata (Burm., F) Ness) are diterpene lactones, namely andrographolide and deoxyandrographolide which have been reported to have antidiabetic, cytotoxic, antiatherosclerosis, anti-inflammatory, and antimicrobial activity. There are many studies that performed the isolation of deoxyandrographolide and andrographolide from A. paniculata herbs, but most of them included several steps that make them not efficient. This research was conducted to do an isolation of deoxyandrographolide and andrographolide through liquid-liquid fractionation (LLF) due to its simplicity, low cost, and time efficient. The extraction of deoxyandrographolide and andrographolide from the herbs was carried out using chloroform as the solvent by using Soxhlet apparatus, and LLF was performed to isolate the compounds. The identities of the compounds were confirmed by TLC scanner compared to its standard references. Hence, these present methods were successfully isolated and determined deoxyandrographolide and andrographolide of A. paniculata. The compounds were also showed relatively moderate cytotoxicity on 3T3-L1 cell lines using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) assay, with LC50 of deoxyandrographolide and andrographolide; 29.3173 µg/mL and 37.7011 µg/mL, respectively.
Citizenship Deprivation as a Counterterrorism Measure in Europe
Authors: Kulic Sara
Published: October 2021

Since the proclamation of the Islamic State in Iraq and Syria (ISIS) Caliphate in June 2014, an unprecedented number of jihadi supporters in Europe have left their countries to fight alongside the organisation in Iraq and Syria. Over the years, ISIS has lost much of its territory and was militarily defeated in 2019, leaving a large number of members waiting in Kurdish camps and Iraqi prisons for their fate to be decided. Instead of repatriating foreign fighters, many European countries have started to use citizenship deprivation as a tool of preventing them from returning. Under the rationale of protecting national security and deterring possible supporters, it has been argued that citizenship deprivation is nothing more than risk exportation, with notable implications for a whole international community. This article provides an overview of the rationale behind citizenship deprivation as a counterterrorism measure and highlights how, from a counterterrorism perspective, shifting the problem instead of addressing it, could be counterproductive and undermine the fight against terrorism. The article concludes that despite numerous implications, following the public pressure to harshly respond to terrorism, it is unlikely that the popularity and use of citizenship deprivation as a counterterrorism measure will be in decrease soon.
A methodological framework to allocate storage space for outbound containers
Authors: Gracia María D.
Published: October 2021

The staking of containers on ideal locations within the yard is a tactical decision that affects the productivity of container terminals. The goal is to improve posterior loading and retrieval operations, to get better use of terminal resources. In this paper, we study how to allocate storage space for outbound containers in container terminals. A two-phase methodological framework is proposed. The first phase groups outbound containers into clusters of similar operational loading conditions. Then in a second phase, a bi-objective storage space assignment model is solved to determine the set of block-bays where groups of similar containers will be stored during the planning horizon. This study presents a double contribution. On one hand, it proposes a new methodological framework that combines operations research and data mining techniques to solve a storage space assignment problem for outbound containers. On the other hand, it analyzes the impact of three factors on four performance metrics used to evaluate the quality and quantity of alternative solutions to the problem of allocation of storage space for outbound containers. The experimental framework is composed of an experimental design study to assess the impact of three factors on four performance metrics used to assess the quality of the storage space assignment solutions, and a case study to validate the proposed approach. The experimental results reveal that the storage yard's capacity and the number of clusters used to group the containers destined to a vessel are the main factors that affect the number and quality of alternative solutions.
Seguridad en el laboratorio: una aproximación práctica
Authors: Reina Miguel , Reina Antonio
Published: October 2021

En este artículo se presenta una práctica experimental enfocada en las medidas de seguridad en el laboratorio para los estudiantes de los primeros semestres de la carrera de Química y afines. En esta contribución se propone que los estudiantes realicen algunos procedimientos experimentales que les permitan comprender la importancia del uso del equipo de protección y el seguimiento de las normas de seguridad como herramientas fundamentales para reducir el riesgo a la salud. De esta manera, aprenderán a leer y extraer información de las fichas de seguridad, a distinguir y manejar ácidos y bases, a escoger adecuadamente entre batas y guantes de distintos materiales y cómo deben tratarse los residuos. Además, hemos incluido una guía detallada para el docente en la que se incluyen las respuestas completas a los cuestionarios. Este trabajo tiene como objetivo central proveer a los estudiantes las herramientas necesarias para prevenir accidentes y para saber cómo reaccionar ante ellos en los laboratorios de química básica y de investigación.
Refleksivni dijalog s tekstom: tumačenje lirike nakon (post)strukturalizma
Authors: Brajović Tihomir
Published: October 2021

A REFLEXIVE DIALOG WITH THE TEXT: INTERPRETATION OF
POETRY AFTER (POST)STRUCTURALISM
Starting from theoretical concepts of reading and understanding of literature, this
paper deals with actual problems of interpretation of poetry after structuralism
and poststructuralism. After brief insight into the phenomenological theory and
practice (H. G. Gadamer, W. Kayser, E. Steiger) as the key impulse to modern
interpretation approach, first part of the paper consists of a historical survey of
production-construction and reception-lecturer paradigms and their main representatives
(R. Jakobson, M. Riffaterre, T. S. Eliot, H. Bloom, H. R. Jauss, J.
Derrida, P. De Man, S. Fisch). The paper proposes dialogical theory (M. Bakhtin,
P. Zima) and reflexive identity of reading/interpretation (T. Brajović) as suitable critical
concepts for a contemporary approach to interpreting poetry. Accordingly,
theoretical constructs of the lyrical dominant and interpretative focus are suggested
as the methodological tools, which are, then, applied to the interpretation of two
canonical modern Croatian poems – “Svakidašnja jadikovka”/“Everyday Lament”
by Tin Ujević, and “Mrtvac”/“The Dead Man” by Vladimir Vidrić.
Keywords: reading, understanding, interpretation, dialogical theory, reflexivity,
lyrical dominant, interpretative focus
Cyberbullying Detection System Using Machine Learning
Authors: Kabeer Ms. Shama
Published: October 2021

Abstract: Cyberbullying is an online form of harassment. By posting, commenting, sending, or distributing personal, derogatory, false, or nasty stuff about others that can shame or humiliate them, this conduct is done with the goal of harming others. Once such content is published on the internet, it remains accessible indefinitely. This activity is considered unlawful, and it is more widespread among children and teenagers. Cyberbullying is an online epidemic that has the potential to result in devastating outcomes such as violence and suicide, and so must be dealt with swiftly and properly. To detect bullying behavior in textual messages, a real-time cyberbullying detection system based on machine learning—Naïve Bayes Algorithm is presented. The model was created to determine whether a tweet was bullying or non-bullying in nature. Also, to assist victims in dealing with bullying difficulties without their identities being revealed. Keywords: Machine Learning, Cyberbullying, Naïve Bayes, Cybercrimes, Cyberbullying Detection
Study on Tyre Rubber Modified Bitumens Mix for Road Asphalt Mixtures
Authors: Prajapati Shantanu
Published: October 2021

Abstract: In this study the strength & stability characteristics of bituminous mix for 80/100 grade bitumen is to studied and the effect of waste crumb rubber strength and stability characteristics in Bituminous mix and rubber bituminous mix is analyzed. Keywords: voids in mineral aggregates (VMA), voids filled with bitumen (VFB) Method, Crumb rubber, Crumb rubber bituminous mix, stability, flow, Bulk Density
Use of E-Resources by The Teaching Staff of Engineering Colleges in West Godavari District, AP. A Survey
Authors: Raju Avala Peddi
Published: October 2021

Abstract: Utility of e-resources in the present era of Information Technology in a topic for study, because it support teaching learning and research activities of the present user community particularly faculty members. Enormous amount of money is needed for subscribing to e-resources. The purpose of this study is to find out the awareness, availability and the use of eresources by the teaching faculty of engineering colleges in West Godavari. District. AP. It also look into the barriers, the users are facing while using the e-resources and their level of satisfaction. A survey was conducted among the teaching staff members of 12 selected engineering colleges in West Godavari District. AP out of 225 questionnaires distributed, 160 responses were received back. The findings shows that the generality of teaching staff members are thoroughly aware about the e-resources and most of them are using e-resources at least once in a week. Majority of the teaching members using desktop computers for accessing the e-resources. Maximum engineering colleges provide e-resources facility availability is good. Majority of the teaching staff members are using desktop computer for accessing the e-resources and the main purpose of using them is for teaching. The study also reveals that all most faculty members are satisfied with the facilities available for accessing eresources. Keywords: Engineering College Library - E-resources – Teaching Staff members –Usage -Interne
Role of Geologists During Tunnel Construction and Face Mapping to Decide the Required Tunnel Support
Authors: Gupta Deepak Parkash
Published: October 2021

Abstract: The stability of underground structures is an important aspect during design, construction and execution Phase. Depending on the geotechnical conditions and influencing factors, different failure modes during execution mode can be expected, and depending on the potential failure modes, boundary conditions and specific construction measures to ensure stability have to be chosen. The most important is developing a realistic estimate of the expected ground conditions and their potential behaviour/failure modes as a result of the excavation. The variability of the geological conditions including local ground structure, ground parameters, stress and ground water conditions requires that a consistent and specific procedure is used. The other is to design an economic and safe excavation and support method for the determined ground behaviours. The discussion of role of geologists during design stage is beyond the scope of the present study. The main objective of this study is to present the role of geologists during the construction stage. Keywords: Geologist, Stress, Behaviour, RMR, Q Value, RQD, Rock Mass
Design and Analysis of 2-Stage Gearbox for ATV Applications
Authors: Surnis Prathmesh
Published: October 2021

Abstract: The main objective of this project is to design and develop a 2-Stage- Reduction gearbox for all terrain vehicles application. Gearbox is a mechanical unit consisting of series of gears within a housing (casing) or a simple gear train. It is the main component of the powertrain system as it provides speed and torque conversions from the Engine or CVT to the wheels. The gears inside of gearbox can be any one of a number of different types of the gear that are available in the market i.e., from spur gears to worm gears and planetary gears as well. In this report the gearbox is made from a helical gear train. This report focuses on selection of overall reduction ratio of the gearbox, material selection, selection of gear dimensions, selection of shaft dimension, design of key and bearing selection from SKF bearing catalogue. The bending and wear strengths are calculated to determine factor of safety and later, Finite element analysis is performed to validate the results. Keywords: Geartrain, Shaft Design, SKF Bearings, Solidworks, FEA