bluuebunny/crossref_metadata_2025 huggingface dataset:
DIRETRIZES DO PROGRAMA NACIONAL DE EDUCAÇÃO PARA A PARTICIPAÇÃO EM SAÚDE
Authors: Martins Antonia Vasconcelos
Published: March 2017

A Coordenação de Educação para a Saúde começou a ~nplantação de um plano de trabalho em mato de 1992. 0 modelo pedagógico EPPS permeia todos os projetos e ações da Coordenação, pois, espera-se com esse recurso estratégico desenvolver uma unidadeconceitual ~ metodológica acerca da ‘educação para a Participação em Saúde” em todas as ações educativas do Ministério da Saúde.
ECOLALIA EM PSICOSES INFANTIS
Authors: Fermamdes Fernanda Dreux Miranda
Published: March 2017

A discussão sobre possíveis funções do comportamento ecolálico é apresentada juntamente com as propostas de diversos autores solve sua caracterização, posssíveis causas e abordagens terapêuticas. A linha pragmática em linguística é sugerida como opção para a análise da comunicação de crianças psicóticas. Um caso é descrito e analisado dentro dessa proposta.
ATRIBUIÇÃO DE NOMES PRÓPRIOS E SEU PAPEL NO DESENVOLVIMENTO SEGUNDO O RELATO DOS NOMEADOS
Authors: Rabinovich Elaine Pedreira , Trovaglini Daniela , Coser Anna Crisíina Pereira Hulle , Esteves Eloane Neves
Published: March 2017

O presente estudo replica e amplia a pesquisa anteriormente realizada por Rabinovich et al (191), sobre o processo de nomeação de crianças tendo como base agora a fala de sujeitos adultos sobre o próprio nome. As categorias ptopostas foram validadas e ampliadas. Concluiu-se que o nome, enquanto “script” outorgado pelos pais, indica, entre outros fatores, o futuro papel do nomeado no seu contexto familiar e social, sendo essainfluência, em grande parte, desconhecida do nomeado.
EDUCAÇÃO PARA FAMÍLIA: UMA PROPOSTA DE TRABALHO PREVENTIVO
Authors: Gomes Heloísa Szimanski
Published: March 2017

Este artigo enfatiza o papel educacional da familia e aponta para a necessidade de instrumentá-la, através de intervenções educativas, nessa sua função socializadora. Esse trabalho de apoio pode ser realizado pela Escola, Universidade e Serviço de Saúde, que somados ao desenvolvimento de pesquisas na área e à formaçao de profissionais delineiam o campo de Educação para a FamDia.
A IMPORTÂNCIA DA CRECHE PARA O PROCESSO DE INSERÇÃO SOCIAL E PARA O INGRESSO DA CRIANÇA NA CULTURA
Authors: Lefèvre Fernando
Published: March 2017

Trata-se aqui de procurar entender o papel da creche para as crianças pobres entre nós, b~asileiros, hoje, considerando a polaridade clássica n~ sociologia entre natureza e cultura.Considera-se, dentro deste referencial, que a creche tem uma import~ncia decisiva neste processo, devido ao fato de que nela as possibilidades de desenvolvimento do sujeito epistêmico que existe em todo ser humano aparecem de modo muito claro.Configura-se, portanto, na creche brasileira atual, uma dialética ou conflito social e ideolog~co entre a prod~açao social do sujeito excluído x a produção social do sujeito epist8mico.
TRAJETÓRIA DA MULHER EM DIREÇAO À ESTERILIZAÇÃO CIRÚRGICA FEMININA: UM ESTUDO FENOMENOLÓGICO
Authors: Marcolino Clarice , Schor Néia
Published: March 2017

Este estudo nasceu de uma preocupação, como enfermeiras e docentes de enfermagem, com as mulheres que vivenciam a escolha do método contraceptivo definitivo - a esterilização cirúrgica feminina. Dessa forma, nossa tryetória neste trabalho consiste na busca de compreensão da vivência das mulheres no processo de escolha desse método contraceptivo. Para essa finalidade, utilizamos a pesquisa qualitativa - enfoque fenomenológico. Esta estratégia possibilitou-nos apreendera essência do fenómeno sem, no -ntanto, prender-nos a fatores determinantes do mesmo. Como forma de desvelar o fenómeno, utilizamos uma pergunta orientadora, que norteou as descrições dos sujeitos sociais: ‘Taie para mim sobre a sua experiência com os jeitos de evitar filhos.” Foram colhidos22 depoimentos, os quais, através de uma análise fenomenológica, evidenciaram seis diferentes temas: a convivência com os métodos contraceptivos temporários; o sentido da esterilização cirúrgica; a participação masculina na contracepção; o seu ser mãe; a condição socioeconômica; o número de filhos e o seu horizonte existencial em face da esterilização. Essa abordagem compreensiva possibilita,pelos seus resultados, abrir novos horizontes na assistência às mulheres que buscam meios para controlar a sua fecundidade.
EDUCAÇAO EM PREVENÇÃO, O ‘X’ DA QUESTÃO: REFLEXÕES SOBRE A CARTILHA “XlS-CASlNHO”
Authors: Beltrame Ideraldo Luiz , Reis Alberto Olavo Advíncula
Published: March 2017

A cartilha apresentada pelo Ministério da Saúde para educação em prevenção das Doenças Sexualmente Transmissiveis e AIDS tem o mérito de ser um instrumento pedagógico devalor, uma vez que coloca a criança em contato com uma série de informações sobre a vida no planeta Terra de uma maneira geral e com os outros homens de forma mais especifica. Porém as considerações que tecemos neste artigo apontam para alguns aspectos da temática desenvolvida na cartilha, que podem acabar traindo o objetivo original do processo ensino-aprendizagem: a educação para a prevenção. Partimos do pressuposto de que a educação é um processo complexoe dinâmico, capaz de incorporar uma reflexão sobre o devir humano: não é exclusivamente informação e acúmulo de conhecimento,-mas implica numa reflexão sobre a forma como se dá a produção de sentido das coisas e os significados a elas atribuidos. Assim, discutimos os principais eixos da cartilha, observando a necessidade de que esta se desfaça das armadilhas da moral judaico-cristã que a permeio, dos dogmas sobre a relação de amor e sobre a sexualidade humana.Para educar é preciso se desencobrir da condição de mestre que tudo sabe e fazer um esforço no sentido de que aquilo que é apresentado como novo, seja desencoberto, numa relação dialógica pelos sujeitos envolvidos.
PRATICAS DE EDUCAÇÃO DA CRIANÇA NA FAMÍLIA: A EMERGÊNCIA DO SABER TÉCNICO-CIENTÍFICO
Authors: Biasoli-Alves Zélia M. M. , Caldana Regina H. L. , Silva Maria Helena G. F. Dias da
Published: March 2017

Face ao grande conjunto de dúvidas e inseguranças evidenciadas pelos adultos quando se deparam com a tarefa de educar as gerações mais novas, propôs-se este estudo contribuir para o aprofundamento da análise do processo de alteração das concepções que norteiam as atitudes assumidas pelos socializadores, ao longo deste século no Brasil, ai incluidos os fatores a ela associados bem como as orientações que costumam procurar. Dados de três pesquisas são analisados, e eles têm por base o relato oral e/ou a informação veiculada pela imprensa escrita.Os resultados mostram o surgimento e a busca do Conhecimento Cientifico a partir da década de 50, que se faz acompanhar de alterações profundas nas formas de criar e educar crianças na familia e permitem que se levante explicações para o faro de, na sociedade brasileira contemporânea, os pais terem tantas dúvidas quanto à melhor maneira de educar sua prole.
DIFERENTES CAMINHOS DE SOCIALIZAÇÃO ATÉ A ADOLESCÊNCIA
Authors: Keller Heidi
Published: March 2017

A diferenciação do curso da vida humana em fases pode ser encarada como uma adaptação a demandas contextuais. As abordagens sociobiológicas têm atribuido às fases desenvolvimentais o status de conquistas filogenéticas ao invés de estágios transitários. Da mesma forma, o padrão e a duração das fases diferem através de contextos e culturas. Ainfancia é vista como a fase em que uma matriz social primária é construída. Embora esta tarefa desenvolvirnental seja universal, sua elaboração especifica difere em backgroundsculturais distintos. Os resultados desenvolvimentais desta fase fornecem as bases para modos especificas de exploração e aprendizado durante a infancia - a fase de aquisição. Umatrajetória tipicamente ocidental e uma trajetória tipicamente não-ociãental são apresentadas, levando, em seguida, a diferentes concepções de adolescência: de um lado, como umamoratória educacional e de desenvolvimento do sela; e, do outro, como o inicio da vida reprodutiva do adulto.
O COTIDIANO DE ESCOLARES NASCIDOS PRÉ-TERMO: PERCEPÇÃO DE CRIANÇAS E FAMILIARES
Authors: Gaíva Maria Aparecida M. , Ferriani Maria Das Graças C.
Published: March 2017

Este é um estudo de cunho qualitativo cujo objetivo é analisar a percepção acerca da vida cotidiana de crianças nascidas pré-termo e hoje em idade escolar, segundo o olhar de mães/familiares e destas crianças. Foram utilizados para esse fim a entrevista semi-estruturada, análise de documentos e a observação assistemática. A análise pautou-se na técnica de análise temática e foi realizada a partir da identificação de três Núcleos Temáticos: Saúde, Família e Escola. Os resultados revelam que as mães/familiares percebem a vida cotidiana de seu filho da seguinte forma: seus filhos são crianças saudáveis/normais. Algumas delas vão muito bem na escola,entretanto outras apresentam dificuldades de aprendizagem. Por outro lado, a maioria das crianças não apresenta problemas de saúde e a vida familiar emerge como aspecto fundamental para elas. O lazer e a religião também fazem parte de seu cotidiano. Para elas estudar é muito importantee a maioria não tem dificuldades na escola, mas os que têm assumem naturalmente o fato. Em relação à qualidade de vida podemos afirmar que todas as crianças têm atendidas suasnecessidades de moradia, educação e lazer; no que concerne à saúde, algumas crianças apresentam limitações funcionais. Portanto nem todas as crianças estudadas vivem uma vida de qualidade.
ALGUNS PRESSUPOSTOS TEÓRICOS PARA “UM EMPREGO” DO CONCEITO DE DESENVOLVIMENTO
Authors: Moraes Maria Cecilia Leite de , Moron Antonio Fernandes
Published: March 2017

Este artigo foi extraído de um capítulo da dissertação “Avaliação Percepto-Motora em Crianças, Com Cerca De Dois Anos De Idade, Nascidas De Mães Portadoras de Hipertensão Arterial” (MORAES, 1997). Nesta investigação pretendeu-se rastrear indícios de sequelas perceptomotoras em filhos de mães hipertensas. Usou-se o Denver Developmental Screening Test, complementado por um estudo contextual para avaliar 0 desenvolvimento da população amostral. Foi necessário caracterizar e referendar o conceito de desenvolvimento, para que ele se tomasse compatível com o trabalho e visão do investigador. É importante salientar que se partiu de alguns “riscos” para o desenvolvimento e chegou-se até a “resiliência”. Em função disso, acredita-se que este ensaio é significativo para os que militam na área de saúde, com ênfase em níveis de desenvolvimento humano.
A RESILIENCIA E O MORAR NA RUA: ESTUDO COM MORADORES DE RUA - CRIANÇA E ADULTOS NA CIDADE DE SÃO PAULO
Authors: Alvarez Aparecida Magali de Souza , Rosenburg Cornélio Pedroso
Published: March 2017

O presente trabalho consistiu em aplicar a categoria Resiliencia no estudo de ex-moradores de lua da região central de São Paulo, que buscaram um outro modo de vida, no sentido dereconhecer a contribuição que esse conceito pode dar ao equacionamento de ações de saúde, em particular da saúde mental, voltadas às populações de rua, no contexto das metrópoles brasileiras. No estudo de caso, foram selecionados quatro adultos e uma criança, egressos de um grupode moradores de nua de um bairro central da cidade de São Paulo, que, do ponto de vista investigativo, foram considerados como possíveis resilientes, ou seja, portadores de capacidade humana de fazer frente às adversidades da vida, superá-las e sairem delas fortalecidos ou, inclusive, transformados. Utilizando entrevistas abertas e semi-estruturadas, fotografias, registros no diário de campo e técnicas de observação, procedeu-se a uma descrição etnográfico da moradia e do modo de morar atual e anterior dos sujeitos participantes do estudo, assim como de suas características psíquicas e sua interação com o meio em que vivem ou viveram. A partir doreconhecimento da trajetória empreendida por eles, estes foram considerados positivamente como resilientes, com base nos conceitos heurísticos “busca de sentido” e “pontos fixos” internos e provenientes do entorno identificados nos sujeitos. Finalmente, reconhece-se a importância do conceito de resiliência em estudos desta natureza e a necessidade de difusão do mesmo para sua efetiva aplicação na área de Saúde Pública.
MODO DE VIDA E RELAÇÃO MÃE CRIANÇA: UM ESTUDO DO ANDAR
Authors: Rabinovich Elaine Pedreira , Carvalho Ana Maria Almeida
Published: March 2017

A idade da marcha independente de 60 criangas paulistanas de O - 12 anos foi analisada com relaçao a alguns aspectos da organiza~ao física e psicológica do ambiente doméstico:presença/ausência de condições físicas e condições controladas pela mãe favorecedoras de comportamentos exploratórios infantis (autonomia). Propõe-se um esquema de análise no qual os conceitos de apego e autonomia, relativos à relação mãe-criança, são associados aos de “lugar” e “espaco”, relativos a organização do ambiente doméstico; ambas dimensões são compreendidas como expressão de um “sistema de desenvolvimento” que inclui a organização psicológica da díade mãe-criança e sua suscetibilidade ao sistema de crenças e as condições de vida concretas nas quais o desenvolvimento ocorre. Uma comparação com as práticas de criação e a organização ambiental numa sociedade de caça-coleta (!Kung) e usada para realçar o conceito desistema de desenvolvimento.
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Authors: Gomes Nilce Helena
Published: March 2017

Consultores entrevistados Vanderlino Nogueira Neto - Professor coordenador do Núcleo de Estudos e Pesquisas do Direito Insurgente - NUDIN - Faculdade de Direito da Bahia; Luiz César Machado de Macedo - Chefe do Serviço de Defesa dos Preitos Hurnanos e Sociais e professor concursado de Filosofia da rede estadual de Ensino.
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Authors: Gomes Nilce Helena
Published: March 2017

Consultora entrevistada: Rosane Ferreira Faria—Presidente do Conselho Municipal de Direitos da Crianca e do Adolescente de São José dos Campos.
Encephalocraniocutaneous Lipomatosis: Case Report of a Rare Disorder
Authors: Singh Kirti , Bhattacharyya Mainak , Wali Keerti , Jain Virendra , Kapoor Seema , Kumar Sumit
Published: March 2017

Encephalocraniocutaneous lipomatosis (ECCL), a rare neurocutaneous syndrome is characterized by profound mental retardation, early onset of seizures, unilateral temporofrontal lipomatosis, ipsilateral cerebral and leptomeningeal lipomatosis, cerebral malformation, calcification, lipomas of skull, eye, heart, connective tissue nevi along with alopecia. This case highlights the condition in a 4 day old male child who presented with bilateral red eye with mass lesion. Complete evaluation showed conjunctival hyperemia, lipodermoids with corneal vascularisation and healed choroiditis patches OD. Systemic work up revealed ipsilateral nevus psiloliparus, and undescended testis with megalourethra. Radiologic evaluation showed revealed diffuse cerebral atrophy, subarachnoid cyst in right temporal region along with dysplastic cortex, enlargement of both ventricular system and extra-axial CSF spaces along with marked atrophy of right antero-inferior temporal parenchyma. Child was managed conservatively and over a one year follow up the ocular condition remained unchanged with OU limbal lipodermoids and no conjunctival congestion.
Sequential One‐Pot Synthesis of Dipeptides through the Transient Formation of CDI‐N‐Protected α‐Aminoesters
Authors: de Figueiredo Renata Marcia , Suppo Jean‐Simon , Midrier Camille , Campagne Jean‐Marc
Published: March 2017

The synthesis of dipeptides through a sequential one‐pot procedure from commercially available protected amino acids is described. The transformation relies on the use of in situ generated transiently CDI‐protected α‐amino esters (CDI, e.g. N,N′‐carbonyldiimidazole). In addition of being a highly atom‐economical process, the couplings take place under very mild and neutral conditions without adding a base to the reaction medium. This protocol provides a concise and less costly route to dipeptide derivatives (12 examples, up to 87% yield) and is compatible with commonly used N‐urethane protecting groups. Moreover, no epimerization was detected even when sensitive Boc‐Cys(Bn)−OH was used.

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A 3D‐Engineered Conformal Implant Releases DNA Nanocomplexs for Eradicating the Postsurgery Residual Glioblastoma
Authors: Yang Yuan , Du Ting , Zhang Jiumeng , Kang Tianyi , Luo Li , Tao Jie , Gou Zhiyuan , Chen Shaochen , Du Yanan , He Jiankang , Jiang Shu , Mao Qing , Gou Maling
Published: March 2017

Gene therapy has great promise for glioblastoma treatment; however, it remains a great challenge to efficiently deliver genes to the brain. The incomplete resection of glioblastoma always leads to poor prognosis. Here, a 3D‐engineered conformal implant for eradicating the postsurgery residual glioblastoma is designed. This implant is constructed by 3D‐printing technology to match the tumor cavity and release an oncolytic virus‐inspired DNA nanocomplex to kill glioblastoma cells through apoptosis induction. Meanwhile, a 3D‐engineered subcutaneous glioblastoma xenograft is built to mimic the resection tumor cavity in mice. Insertion of the implant into the glioblastoma resection cavity efficiently delays tumor recurrence and significantly prolongs overall survival. This study provides a proof‐of‐concept of glioblastoma therapy using a conformal implant that releases oncolytic DNA nanocomplexs. This strategy can lead to the development of future precision therapy for eradicating postsurgery residual tumors.
Environment‐Responsive 8‐CF3‐BODIPY Dyes with Aniline Groups at the 3 Position: Synthesis, Optical Properties and RI‐CC2 Calculations
Authors: Petrushenko Konstantin B. , Petrushenko Igor K. , Petrova Olga V. , Sobenina Lyubov N. , Ushakov Igor A. , Trofimov Boris A.
Published: March 2017

The spectroscopic and the photophysical properties of isomeric environment‐sensitive BODIPY derivatives in different solvents are reported. The simultaneous presence of the strong electron‐acceptor CF3 and electron‐donor NH2 group in the structure of BODIPY, as well as the position of the NH2 group on the aryl ring, showed a significant effect on the spectroscopic and fluorescence characteristics of the BODIPY chromophore, both experimentally and theoretically. The comparison of meta and para derivatives (1 a and 1 b) shows that, in both cases, they have a very low quantum yield (Φf) and fluorescence lifetime (τf) in the solvents used (except for n‐hexane), therefore, they are potentially suitable as turn‐on fluorescence sensors. The twisted intramolecular charge transfer (TICT) mechanism was adopted to explain solvate‐induced fluorescence quenching. Besides this, there is a strong pH dependence on the photophysical behavior of the two isomers, which could also lead to applications as pH sensors. On the other hand, only 1 a can be a useful probe for CO2 sensing. Owing to a weaker electron‐donor character of the NHCOMe group in comparison with the NH2 group, the position of the fluorescence “off–on” threshold of BODIPY 1 c and 1 d is shifted to the side of more polar solvents than for 1 a and 1 b.
Unsymmetric Twofold Scholl Cyclization of a 5,11‐Dinaphthyltetracene: Selective Formation of Pentagonal and Hexagonal Rings via Dicationic Intermediates
Authors: Chaolumen  , Murata Michihisa , Wakamiya Atsushi , Murata Yasujiro
Published: March 2017

Even though the Scholl reaction is one of the most powerful processes for the synthesis of polycyclic aromatic hydrocarbons (PAHs), its mechanism still remains a subject of discussion. Herein, we report a unique twofold Scholl cyclization of a 5,11‐dinaphthyltetracene. Single‐crystal X‐ray diffraction analysis of the cyclization product revealed that unsymmetric cyclizations of the two naphthyl groups resulted in the formation of fully unsaturated pentagonal and hexagonal rings. The thus obtained product exhibits a twisted π‐surface and an absorption band that reaches up to 950 nm. A combined experimental and theoretical study showed that such unsymmetric Scholl cyclizations can be rationalized in terms of a mechanism that involves dicationic intermediates, which stands in contrast to previously reported pathways based on radical cations and arenium ions.
Chemosensing hybrid materials: Chalcones‐functionalized cage‐like mesoporous SBA‐16 material for highly selective detection of toxic metal ions
Authors: El‐Nahass Marwa N. , Fayed Tarek A.
Published: March 2017

Highly selective and low‐cost optical nanosensors of organic–inorganic hybrid materials for heavy metal ions detection have been prepared via the functionalization of mesoporous silica (SBA‐16) with chalcone fluorescent chromophores. The successful attachment of organic chalcone moieties and preservation of original structure of SBA‐16 after the anchoring process were confirmed by extensive characterizations using various techniques like Fourier transform infrared and UV–visible spectroscopies, transmission electron microscopy, nitrogen adsorption–desorption isotherms, low‐angle X‐ray diffraction and thermogravimetric analysis. The colorimetric behaviour, selectivity and sensitivity were also investigated. The optical nanosensors respond selectively to heavy metal ions, such as Mn2+, Fe3+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+ and Hg2+, with observable colour changes in 0.01 M Tris–HCl aqueous buffer solution. Also, the optical sensing ability of the investigated nanosensors to the mentioned metal ions was investigated using steady‐state absorption and emission techniques. Significant increase in the absorption spectra and a static quenching in the emission spectra are observed upon adding various concentrations of the studied metal ions. The spectral changes as well as the observable colour changes suggest that the investigated nanosensors are suitable for simple, economic, online analysis and remote design of these toxic metal ions with fast kinetic responses. Finally, the low detection limits for all the studied metals are in good agreement with those recommended by both the US Environmental Protection Agency and World Health Organization, except for Hg2+ and Cd2+, indicating that the investigated nanosensors have hypersensitivity, selectivity and better recognition for all the studied metal ions.
Orthopalladated complexes of phosphorus ylide: Poly(N‐vinyl‐2‐pyrrolidone)‐stabilized palladium nanoparticles as reusable heterogeneous catalyst for Suzuki and Heck cross‐coupling reactions
Authors: Karami Kazem , Abedanzadeh Sedigheh , Vahidnia Omolbanin , Herves Pablo , Lipkowski Janusz , Lyczko Krzysztof
Published: March 2017

The phosphorus ylide [Ph3PCHC(O)C6H4‐NO2–4] reacted with Pd(OAc)2 to give the C,C‐orthometallated complex [Pd{κ2(C,C)‐C6H4PPh2C(H)CO(C6H4‐NO2–4)}(μ‐OAc)]2, which underwent bridge exchange reaction with NaN3, NaCl, KBr and KI, respectively, to afford the binuclear C,C‐orthopalladated complexes [Pd{κ2(C,C)‐C6H4PPh2C(H)CO(C6H4‐NO2–4)}(μ‐X)]2 (X = N3 (1), Cl (2), Br (3) and I (4)). The complexes were identified using spectroscopy (infrared and NMR), CHNS technique and single‐crystal X‐ray structure analysis. Thereafter, palladium nanoparticles with narrow size distribution were easily prepared using the refluxing reaction of iodo‐bridged orthopalladated complex 4 with poly(N‐vinyl‐2‐pyrrolidone) (PVP) as the protecting group. The PVP‐stabilized palladium nanoparticles were characterized using a variety of techniques including X‐ray diffraction, transmission and scanning electron microscopies, energy‐dispersive X‐ray spectroscopy, inductively coupled plasma analysis and Fourier transform infrared spectroscopy. The catalytic activity of the PVP‐stabilized palladium nanoparticles was evaluated in the Suzuki reaction of phenylboronic acid and the Heck reaction of styrene with aryl halides of varying electron densities. This catalyst exhibited excellent catalytic activity for Suzuki cross‐coupling reactions in ethanol–water. Notably, aryl chlorides which are cheaper and more accessible than their bromide and iodide counterparts also reacted satisfactorily using this catalyst. After completion of reactions, the catalyst could be separated using a simple method and used many times in repeat cycles without considerable loss in its activity.
Localization of Alpha‐Keratin and Beta‐Keratin (Corneous Beta Protein) in the Epithelium on the Ventral Surface of the Lingual Apex and Its Lingual Nail in the Domestic Goose (Anser Anser f. domestica) by Using Immunohistochemistry and Raman Microspectroscopy Analysis
Authors: Skieresz‐Szewczyk Kinga , Jackowiak Hanna , Buchwald Tomasz , Szybowicz Mirosław
Published: March 2017

The epithelium of the ventral surface of the apex of the tongue in most birds is specified by the presence of the special superficial layer called lingual nail. The aim of the present study is to determine the localization of the alpha‐keratin and beta‐keratin (corneous beta protein) in this special epithelium in the domestic goose by using immunohistochemistry staining and the Raman spectroscopy analysis. Due to lack of commercially available antibodies to detect beta‐keratin (corneous beta protein), the Raman spectroscopy was used as a specific tool to detect and describe the secondary structure of proteins. The immunohistochemical (IHC) detections reveal the presence of alpha‐keratin in all layers of the epithelium, but significant differences in the distribution of the alpha‐keratin in the epithelial layers appear. The staining reaction is stronger from the basal layer to the upper zone of the intermediate layer. The unique result is weak staining for the alpha‐keratin in the lingual nail. Applications of the Raman spectroscopy as a complementary method not only confirmed results of IHC staining for alpha‐keratin, but showed that this technique could be used to demonstrate the presence of beta‐keratin (corneous beta protein). Functionally, the localization of alpha‐keratin in the epithelium of the ventral surface of the lingual apex provides a proper scaffold for epithelial cells and promotes structural integrity, whereas the presence of beta‐keratin (corneous beta protein) in the lingual nail, described also as exoskeleton of the ventral surface of the apex, endures mechanical stress. Anat Rec, 300:1361–1368, 2017. © 2017 Wiley Periodicals, Inc.
The electric fence to cell‐cycle progression: Do local changes in membrane potential facilitate disassembly of the primary cilium?
Authors: Urrego Diana , Sánchez Araceli , Tomczak Adam P. , Pardo Luis A.
Published: March 2017

Kv10.1 is a voltage‐gated potassium channel relevant for tumor biology, but the underlying mechanism is still unclear. We propose that Kv10.1 plays a role coordinating primary cilium disassembly with cell cycle progression through localized changes of membrane potential at the ciliary base. Most non‐dividing cells display a primary cilium, an antenna‐like structure important for cell physiology. The cilium is disassembled when the cell divides, which requires an increase of Ca2+ concentration and a redistribution of phospholipids in its basal region, both of which would be facilitated by local hyperpolarization. Cells lacking Kv10.1 show impaired ciliary disassembly and delayed entrance into mitosis. Kv10.1 is predominantly expressed during G2/M, a critical period for ciliary resorption, and localizes to the ciliary base and vesicles associated with the centrosome. This could explain the influence of Kv10.1 in cell proliferation, as well as phenotypic features of patients carrying gain of function mutations in the gene.
The diversity of experimental organisms in biomedical research may be influenced by biomedical funding
Authors: Erick Peirson B. R. , Kropp Heather , Damerow Julia , Laubichler Manfred D.
Published: March 2017

Contrary to concerns of some critics, we present evidence that biomedical research is not dominated by a small handful of model organisms. An exhaustive analysis of research literature suggests that the diversity of experimental organisms in biomedical research has increased substantially since 1975. There has been a longstanding worry that organism‐centric funding policies can lead to biases in experimental organism choice, and thus negatively impact the direction of research and the interpretation of results. Critics have argued that a focus on model organisms has unduly constrained the diversity of experimental organisms. The availability of large electronic databases of scientific literature, combined with interest in quantitative methods among philosophers of science, presents new opportunities for data‐driven investigations into organism choice in biomedical research. The diversity of organisms used in NIH‐funded research may be considerably lower than in the broader biomedical sciences, and may be subject to greater constraints on organism choice.
New 1,7‐Disubstituted Perylenediimides as Molecular Acceptors for Organic Solar Cells
Authors: Park Hea Jung , Kim Mi‐Jeong , Park Jong Baek , Kang In‐Nam , Yoon Ung Chan , Hwang Do‐Hoon
Published: March 2017

Two perylenediimides (PDIs), PT and PT2, functionalized with thiophene heterocycles on the 1,7‐positions of the bay region were synthesized and utilized in inverted bulk‐heterojunction (BHJ) polymer solar cells as acceptors in the photoactive layer. The synthesized PDIs were thermally stable up to 453°C and soluble in chlorinated solvents such as dichloromethane and chloroform. PT or PT2 was blended with poly[4,8‐bis(5‐(2‐ethylhexyl)thiophen‐2‐yl)benzo[1,2‐b:4,5‐b′]bithiophene‐co‐3‐fluorothieno[3,4‐b]thiophene‐2‐carboxylate] (PCE‐10) as a donor material. The inverted BHJ solar cell fabricated using the PCE‐10:PT photoactive layer showed the highest power conversion efficiency (PCE) of 2.06%. Film morphology studies of PCE‐10:PDI blends revealed a relationship between the film nanostructure and device performance.
Exploring one‐sided communication and synchronization on a non‐cache‐coherent many‐core architecture
Authors: Christgau Steffen , Schnor Bettina
Published: March 2017

The ongoing many‐core design aims at core counts where cache coherence becomes a serious challenge. Therefore, this paper discusses how one‐sided communication and the required process synchronization can be realized on a non‐cache‐coherent many‐core CPU. The Intel Single‐chip Cloud Computer serves as an exemplary hardware architecture. The presented approach is based on software‐managed cache coherence for MPI one‐sided communication. The prototype implementation delivers a PUT performance of up to 5 times faster than the default message‐based approach and reveals a reduction of the communication costs for the NAS Parallel Benchmarks 3‐D fast Fourier Transform by a factor of 5. Further, the paper derives conclusions for future non‐cache‐coherent architectures.
Cardiac and peripheral autonomic control in restrictive cardiomyopathy
Authors: Sayegh Ana Luiza C. , dos Santos Marcelo R. , Sarmento Adriana O. , de Souza Francis R. , Salemi Vera M.C. , Hotta Viviane T. , Marques Akothirene Cristhina D.B. , Krämer Heidrum H. , Trombetta Ivani C. , Mady Charles , Alves Maria Janieire de Nazaré Nunes
Published: March 2017

Aims

Autonomic dysfunction determines the advance of dilated cardiomyopathy (DCM) and is related to poor outcomes. However, this autonomic imbalance is unknown in patients with restrictive cardiomyopathy (RCM) even though they have similar symptoms and poor quality of life as DCM patients have. The aim of this study was to evaluate if autonomic and neurovascular controls were altered in RCM patients.

Methods and results

Fifteen RCM patients, 10 DCM patients, and 10 healthy subjects were evaluated. Heart rate and blood pressure (BP) were recorded. Peripheral sympathetic activity [muscle sympathetic nerve activity (MSNA)] by microneurography and cardiac sympathetic activity by power spectrum analysis of heart rate variability. Spontaneous baroreflex sensitivity (BRS) was evaluated by the sequence method and forearm blood flow by venous occlusion plethysmography. Both cardiomyopathy groups had higher MSNA frequency (P < 0.001) and MSNA incidence (P < 0.001), higher cardiac sympathovagal balance (P < 0.02), reduced BRS for increase (P = 0.002) and for decrease in BP (P = 0.002), and lower forearm blood flow (P < 0.001) compared with healthy subjects. We found an inverse correlation between BRS for increase and decrease in BP and peripheral sympathetic activity (r = −0.609, P = 0.001 and r = −0.648, P < 0.001, respectively) and between BRS for increase and decrease in BP and cardiac sympathetic activity (r = −0.503, P = 0.03 and r = −0.487, P = 0.04, respectively).

Conclusions

The RCM patients had cardiac and peripheral autonomic dysfunctions associated with peripheral vasoconstriction. Nonetheless, the presence of normal ejection fraction underestimates the evolution of the disease and makes clinical treatment difficult. These alterations could lead to a similar cardiovascular risk as that observed in DCM patients.
First Examples of Polynuclear Lanthanide Diethylene Glycol Based Coordination Clusters
Authors: Peng Guo , Zhang Ying‐Ying , Li Zhao‐Yang , Kostakis George E.
Published: March 2017

Five lanthanide coordination clusters (CCs) [Ln7(µ3‐OH)4(deg)2(Hdeg)2(ben)11]·xCH3CN [Ln = Eu (1), Gd (2), Tb (3), Dy (4), Ho (5); H2deg = diethylene glycol, Hben = benzoic acid; x = 7 for 1–4, x = 6 for 5], with diethylene glycol and benzoic acid as ligands, have been prepared and structurally characterized. All CCs consist of a heptanuclear lanthanide core with a scarce tip‐sharing double‐butterfly topology. Magnetic measurements revealed that CC 4 exhibits slow magnetic relaxation, with an energy barrier of about 6 K, whereas CC 3 shows outstanding magnetocaloric effects, with an entropy change of 34.6 J Kg–1 K–1 at 2 K and ΔH = 7 T. The photoluminescence properties of CCs 1, 3, and 4 were also investigated, displaying intense characteristic emission spectra of EuIII, TbIII, and DyIII ions.
Structural Insights into the Hydrogen‐Bonding and Folding Pattern in Ant‐Ant‐Pro‐Gly Tetrapeptides
Authors: Baravkar Sachin B. , Kotmale Amol S. , Shaikh Samir R. , Gonnade Rajesh G. , Sanjayan Gangadhar J.
Published: March 2017

In this paper, we provide structural insights into the hydrogen‐bonding and folding pattern in Ant‐Ant‐Pro‐Gly tetrapeptides (Ant: anthranilic acid; Pro: proline; and Gly: glycine). Comparison of the C‐terminal esters and their amide analogs revealed strikingly different H‐bonding networks. Whereas the ester analogs displayed an open structure without terminal H‐bonding interactions, the amide analogs showed a completely folded structure. Structural details were revealed by using a combination of X‐ray crystal structure studies and NOE‐based molecular dynamics (MD) simulation studies.
Replaceable links with direct brace attachments for eccentrically braced frames
Authors: Bozkurt Mehmet Bakır , Topkaya Cem
Published: March 2017

This paper reports findings of an experimental study conducted on replaceable links for steel eccentrically braced frames (EBFs). A replaceable link detail which is based on splicing the directly connected braces and the beam outside the link is proposed. This detail eliminates the need to use hydraulic jacks and flame cutting operations for replacement purposes. Performance of this proposed replaceable link was studied by conducting eight nearly full‐scale EBF tests under quasi‐static cyclic loading. The link length ratio, stiffening of the link, loading protocol, connection type, bolt pretension, gap size of splice connections, and demand‐to‐capacity ratios of members were considered as the prime variables. The specimens primarily showed two types of failure modes: link web fracture and fracture of the flange at the link‐to‐brace connection. No failures were observed at the splice connections indicating that the proposed replaceable link detail provides an excellent response. The inelastic rotation capacity provided by the replaceable links satisfied the requirements of the AISC Seismic Provisions for Structural Steel Buildings (AISC341–10). The overstrength factor of the links exceeded 2.0, which is larger than the value assumed for EBF links by design provisions. The high level of overstrength resulted in brace buckling in one of the specimens demonstrating the importance of overstrength factor used for EBF links. Copyright © 2017 John Wiley & Sons, Ltd.
Integrating islands of knowledge for greater synergy and efficiency in crop research
Authors: Borrell Andrew , Reynolds Matthew
Published: March 2017

A transnational approach to plant science is required to address global challenges such as food security and climate change. Action from the plant, crop and agricultural science communities will be required to meet these challenges. Islands of knowledge (e.g. crop, discipline, scale, environment, organization) need to be better integrated. Mapping is needed to identify gaps and make connections between these islands. Translational research, spanning from the molecular to farm scale, should be the focus. We need more `integrators' to manage complex global projects and integration should be recognized as an important skill in itself. We need to advocate teamwork over individuality ‐ and reward teams. Impact should be taken much more seriously as an outcome and we need to better understand impact pathways. Focusing on key game‐changers will more likely lead to impact rather than attempting to do everything.
Microscopic diagnosis of the leaf and stem of Piper solmsianum C.DC
Authors: Bertocco A. R. P. , Migacz I. P. , Santos V. L. P. , Franco C. R. C. , Silva R. Z. , Yunes R. A. , Cechinel‐Filho V. , Budel J. M.
Published: March 2017

Piper solmsianum C.DC., which is popularly known as pariparoba, is a shrub that measures 1–3 m in height and it inhabits areas with wet tropical soils. The objective of this study was to analyze the leaf and stem anatomy using light microscopy, scanning electron micrographs, and energy‐dispersive X‐ray spectroscopy in order to provide information for species identification. The anatomical profile showed the following main microscopic markers: hypostomatic leaf; hypodermis layer on both sides; pearl glands; biconvex midrib shape; five collateral vascular bundles in open arc with the central bundle larger than the others; circular stem shape; collateral vascular bundles arranged in two rings; sinuous sclerenchymatic sheath in the pith; secretory idioblasts; and starch grains in the mesophyll, in the ground parenchyma of the midrib, petiole, and in the stem; and six morphotypes of calcium oxalate crystals (styloids, cuneiform, tabular crystal rosettes, cuneiform crystal rosettes, elongated square dipyramids, as well as very elongated square dipyramids).
Circular coloring of signed graphs
Authors: Kang Yingli , Steffen Eckhard
Published: March 2017

Let ( be two positive integers. We generalize the well‐studied notions of ‐colorings and of the circular chromatic number to signed graphs. This implies a new notion of colorings of signed graphs, and the corresponding chromatic number χ. Some basic facts on circular colorings of signed graphs and on the circular chromatic number are proved, and differences to the results on unsigned graphs are analyzed. In particular, we show that the difference between the circular chromatic number and the chromatic number of a signed graph is at most 1. Indeed, there are signed graphs where the difference is 1. On the other hand, for a signed graph on n vertices, if the difference is smaller than 1, then there exists , such that the difference is at most .

We also show that the notion of ‐colorings is equivalent to r‐colorings (see [12] (X. Zhu, Recent developments in circular coloring of graphs, in Topics in Discrete Mathematics Algorithms and Combinatorics Volume 26, Springer Berlin Heidelberg, 2006, pp. 497–550)).
Lessons from the first dorsal fin in atheriniforms—A new mode of dorsal fin development and its phylogenetic implications
Authors: Richter Philipp , Moritz Timo
Published: March 2017

The median fins in extant actinopterygians are the product of millions of years of evolution. During this time, different developmental patterns for the dorsal and anal fins emerged leading to a high variation in median fin morphology and ontogeny. In this study, the development of anal and dorsal fins in atheriniforms is described and its consequences for the current phylogenetic hypothesis are discussed. Developmental series of five atheriniform species were investigated using clearing and staining as well as antibody staining. The skeletal elements of the second dorsal fin and the anal fin emerge in a bidirectional pattern. The first dorsal fin, however, arises separately in front of the second dorsal fin after this one is almost completely formed. The pterygiophores of the first dorsal fin, including the interdorsal pterygiophores, develop from caudal to rostral, but the fin‐spines of the first dorsal fin form in the opposite direction. This new mode of fin development has been found in all examined atheriniform species with two dorsal fins. Several morphological characters of atheriniforms, including interdorsal pterygiophores, are also found in one other taxon: the Mugiliformes. Thus, several dorsal fin characteristics may provide evidence for a closer relationship of these two taxa.
Morphological study of a connexin 43‐GFP reporter mouse highlights glial heterogeneity, amacrine cells, and olfactory ensheathing cells
Authors: Theofilas Panos , Steinhäuser Christian , Theis Martin , Derouiche Amin
Published: March 2017

Connexin 43 (Cx43) is the main astrocytic connexin and forms the basis of the glial syncytium. The morphology of connexin‐expressing cells can be best studied in transgenic mouse lines expressing cytoplasmic fluorescent reporters, since immunolabeling the plaques can obscure the shapes of the individual cells. The Cx43kiECFP mouse generated by Degen et al. (FASEBJ 26:4576, 2012) expresses cytosolic ECFP and has previously been used to establish that Cx43 may not be expressed by all astrocytes within a population, and this can vary in a region‐dependent way. To establish this mouse line as a tool for future astrocyte and connexin research, we sought to consolidate reporter authenticity, studying cell types and within‐region population heterogeneity. Applying anti‐GFP, all cell types related to astroglia were positive—namely, protoplasmic astrocytes in the hippocampus, cortex, thalamus, spinal cord, olfactory bulb, cerebellum with Bergmann glia and astrocytes also in the molecular layer, and retinal Müller cells and astrocytes. Labeled cell types further comprise white matter astrocytes, olfactory ensheathing cells, radial glia‐like stem cells, retinal pigment epithelium cells, ependymal cells, and meningeal cells. We furthermore describe a retinal Cx43‐expressing amacrine cell morphologically reminiscent of ON‐OFF wide‐field amacrine cells, representing the first example of a mammalian CNS neuron‐expressing Cx43 protein. In double staining with cell type–specific markers (GFAP, S100ß, glutamine synthetase), Cx43 reporter expression in the hippocampus and cortex was restricted to GFAP+ astrocytes. Altogether, this mouse line is a highly reliable tool for studies of Cx43‐expressing CNS cells and astroglial cell morphology. © 2017 Wiley Periodicals, Inc.
The impact of an integrated electronic medication prescribing and dispensing system on prescribing and dispensing errors: a before and after study
Authors: Hodgkinson Marisa R. , Larmour Ian , Lin Susan , Stormont Adam J. , Paul Eldho
Published: March 2017

Background

Medication errors are a significant problem in Australian hospitals. This is the first study of the impact of an integrated electronic medication prescribing (e‐prescribing) and dispensing system on medication errors.

Aim

To evaluate the impact of an integrated e‐prescribing and dispensing system implemented in outpatient clinics and the emergency department on prescribing and dispensing errors.

Method

Prescribing and dispensing errors were identified over 2 weeks before and after implementation of the integrated system. Errors were identified through original prescription, e‐prescribing and dispensing systems review. Error rates, types, severity and patient waiting times for prescription dispensing were compared.

Results

The study included 379 patients prescribed 654 medicines in the before group and 375 patients prescribed 635 medicines in the after group. Prescribing and dispensing error rates per patient were reduced by 93% (from 2.98 to 0.2; p < 0.0001) and 98% (from 1.27 to 0.03; p < 0.0001), respectively. The proportions of patients with at least one procedural or clinical prescribing error showed significant reductions of 81% (95% CI 77–85%) and 3.4% (95% CI 0.1–6.7%). The proportions of patients with at least one procedural or clinical dispensing error showed signicant reductions of 61% (94% CI 56–66%) and 2% (95% CI 0.7–3.6%). Fifty system‐related prescribing errors were identified. Mean error severity score was minor in both groups. Median patient waiting time for prescription dispensing was reduced by 52% (from 27 to 13 min; p < 0.0001).

Conclusion

Implementation of the integrated system significantly reduced prescribing and dispensing errors and patient waiting times for prescription dispensing. Clinicians need to manage new system‐related errors to reduce associated risks.
Molecular simulation and experimental analysis on thermal and mechanical properties of carbon nanotube/epoxy resin composites with different curing agents at high‐low temperature
Authors: Zhang Wenqing , Li Hao , Gao Liang , Zhang Qingjie , Zhong Weihong , Sui Gang , Yang Xiaoping
Published: March 2017

The performance variation and its associated factors of a polymer composites over a wide temperature range need to be particularly concerned in engineering application. In this article, on the basis of molecular dynamics simulation analysis and experimental verification of glass transition temperature (Tg) of neat epoxy resins and single‐walled carbon nanotube (SWCNT)/epoxy composites with two structures of aromatic diamines curing agents, the elastic modulus of systems were studied from cryogenic temperature (100 K) until near the Tg in depth. Both simulation and experimental results showed that the thermal and mechanical performance of amine‐epoxy systems were enhanced obviously after incorporating SWCNTs of 1 wt% and stiffer amine curing agent molecules, and the elastic modulus was declining as the temperature rising. Further, some microstructure parameters of resin molecules influencing the elastic modulus of amine‐epoxy systems were analyzed, including the cohesive energy density (CED), free volume fraction (FFV), and mean square displacement. Among them, both CED and FFV can be significantly affected by addition of SWCNTs and different amine curing agent, and were closely related to the temperature, which can act as novel criteria to predict and optimize some thermal and mechanical performances of crosslinked resin systems and their composites for serving under different temperature. POLYM. COMPOS., 39:E945–E954, 2018. © 2017 Society of Plastics Engineers
Mechanical Properties of Poly(dopamine)‐Coated Graphene Oxide and Poly(vinyl alcohol) Composite Fibers Coated with Reduced Graphene Oxide and Their Use for Piezoresistive Sensing
Authors: Kang Dongwoo , Shin Young‐Eun , Jo Hye Jin , Ko Hyunhyub , Shin Hyeon Suk
Published: March 2017

High‐strength poly(vinyl alcohol) (PVA) composite fibers are successfully fabricated through gel spinning, and reinforced by poly(dopamine)‐coated graphene oxide (dGO) and exterior reduced graphene oxide (rGO) coating. The mechanical properties of PVA/dGO composite fibers show a dependence on the sheet size of GO and interfacial adhesion force is formed by poly(dopamine) layers. The ultimate tensile strength and Young's modulus of PVA/dGO fibers are 1.58 and 27.2 GPa, and 68.1% and 97.1% higher than neat PVA fiber. In addition, there is an 8.2% and 21.4% increase relative to that of PVA/GO composite fiber. Moreover, exterior rGO layers are shown to reinforce the tensile strength of PVA/dGO composite fibers, and the tensile strength of rGO‐coated PVA/dGO composite fibers is 1.86 GPa. An adhesion force of poly(dopamine) between GO and the PVA matrix can efficiently transfer the tensile load via strong hydrogen bonding at interface, and exterior rGO layers can offer additional tensile strength through interfacial shear strength between rGO sheets. Additionally, a piezoresistive sensing test of rGO‐coated PVA/dGO fiber is shown that a gauge factor of 2.3 under 1% strain is achieved, leading to the potential use of this material in wearable strain gauges.