bluuebunny/crossref_metadata_2025 huggingface dataset:
“Truly holistic?” Differences in documenting physical and psychosocial needs and hope in Portuguese palliative patients
Authors: Julião Miguel , Sobral Maria Ana , Calçada Paula , Antunes Bárbara , Nunes Baltazar , Bragança Ana , Runa Daniela , Faria de Sousa Paulo , Chochinov Harvey Max , Bruera Eduardo
Published: June 2020

Objective

Palliative care (PC) aims to improve patients' and families' quality of life through an approach that relieves physical, psychosocial, and spiritual suffering, although the latter continues to be under-assessed and under-treated. This study aimed to describe the prevalence of physical, psychosocial, and hope assessments documented by a PC team in the first PC consultation.

Method

The retrospective descriptive analysis of all first PC consultations registered in our anonymized database (December 2018–January 2020), searching for written documentation regarding (1) Edmonton Symptom Assessment Scale (ESAS) physical subscale (pain, tiredness, nausea, drowsiness, appetite, shortness of breath, constipation, insomnia, and well-being), (2) the single question “Are you depressed?” (SQD), (3) the question “Do you feel anxious?” (SQA), (4) feeling a burden, (5) hope-related concerns, (6) the dignity question (DQ), and (7) will to live (WtL).

Results

Of the 174 total of patients anonymously registered in our database, 141 PC home patients were considered for analysis; 63% were male, average age was 70 years, the majority had malignancies (82%), with a mean performance status of 52%. Evidence of written documentation was (1) ESAS pain (96%), tiredness (89%), nausea (89%), drowsiness (79%), appetite (89%), shortness of breath (82%), constipation (74%), insomnia (72%), and well-being (52%); (2) the SQD (39%); (3) the SQA (11%); (4) burden (26%); (5) hope (11%); (6) the DQ (33%); and (7) WtL (33%).

Significant differences were found between the frequencies of all documented items of the ESAS physical subscale (29%), and all documented psychosocial items (SQD + SQA + burden + DQ) (1%), hope (11%), and WtL (33%) (p= 0.0000;p= 0.0005;p= 0.0181, respectively).

Significance of results

There were differences between documentation of psychosocial, hope, and physical assessments after the first PC consultation, with the latter being much more frequent. Further research using multicenter data is now required to help identify barriers in assessing and documenting non-physical domains of end-of-life experience.
Slavery and the new history of capitalism
Authors: Burnard Trevor , Riello Giorgio
Published: June 2020

The new history of capitalism (NHC) places a great deal of emphasis on slavery as a crucial world institution. Slavery, it is alleged, arose out of, and underpinned, capitalist development. This article starts by showing the intellectual and scholarly foundations of some of the broad conclusions of the NHC. It proceeds by arguing that capitalist transformation must rely on a global framework of analysis. The article considers three critiques in relation to the NHC. First, the NHC overemphasizes the importance of coercion to economic growth in the eighteenth century. We argue that what has been called ‘war capitalism’ might be better served by an analysis in which the political economy of European states and empires, rather than coercion, is a key factor in the transformation of capitalism at a global scale. Second, in linking slavery to industrialization, the NHC proposes a misleading chronology. Cotton produced in large quantities in the United States came too late to cause an Industrial Revolution which, we argue, developed gradually from the latter half of the seventeenth century and which was well established by the 1790s, when cotton started to arrive from the American South. During early industrialization, sugar, not cotton, was the main plantation crop in the Americas. Third, the NHC is overly concentrated on production and especially on slave plantation economies. It underplays the ‘power of consumption’, where consumers came to purchase increasing amounts of plantation goods, including sugar, rice, indigo, tobacco, cotton, and coffee. To see slavery’s role in fostering the preconditions of industrialization and the Great Divergence, we must tell a story about slavery’s place in supporting the expansion of consumption, as well as a story about production
Speaking for the ‘world power economy’: electricity, energo-materialist economics, and the World Energy Council (1924–78)
Authors: Russ Daniela
Published: June 2020

The emergence of a field of global energy policy is usually traced back to the events around the 1973–74 oil embargo. This article provides a prehistory to this by tracing the genealogy of the ‘global energy economy’. This genealogy is reconstructed through the lens of the World Power Conference (WPC, today the World Energy Council, WEC), a non-governmental international organization founded by a British electro-technical engineer in 1924. In a comparison with the engineering of ‘natural forces’ in the nineteenth-century steam economy, I argue that electricity, and particularly large electrical systems, not only changed the meaning of power and institutionalized a regular documentation of the ‘power economy’, but enabled and concentrated ownership of the ‘forces of nature’ as a productive factor. This more comprehensive view of the role of electricity in the economy gave rise to an energo-materialist economics among the electro-technical engineers, technicians, and planners whom the WPC assembled. The WPC imagined itself as the centre of calculation of this ‘global energy economy’, initiating international standardization and complementing the statistics of international organizations such as the League of Nations and the United Nations. As the integration of all ‘energies’ in one statistical model required conversion factors across very different technical processes, it took the urgency of the oil crisis for the WEC to compile a global energy balance, thus statistically ‘representing’ the state of the ‘global energy economy’.
WITTGENSTEIN’S ELIMINATION OF IDENTITY FOR QUANTIFIER-FREE LOGIC
Authors: LAMPERT TIMM , SÄBEL MARKUS
Published: June 2020

One of the central logical ideas in Wittgenstein’sTractatus logico-philosophicusis the elimination of the identity sign in favor of the so-called “exclusive interpretation” of names and quantifiers requiring different names to refer to different objects and (roughly) different variables to take different values. In this paper, we examine a recent development of these ideas in papers by Kai Wehmeier. We diagnose two main problems of Wehmeier’s account, the first concerning the treatment of individual constants, the second concerning so-called “pseudo-propositions” (Scheinsätze) of classical logic such as$a=a$or$a=b \wedge b=c \rightarrow a=c$. We argue that overcoming these problems requires two fairly drastic departures from Wehmeier’s account: (1) Not every formula of classical first-order logic will be translatable into asingleformula of Wittgenstein’s exclusive notation. Instead, there will often be a multiplicity of possible translations, revealing the original “inclusive” formulas to beambiguous. (2) Certain formulas of first-order logic such as$a=a$will not be translatable into Wittgenstein’s notation at all, being thereby revealed as nonsensical pseudo-propositions which should be excluded from a “correct” conceptual notation. We provide translation procedures from inclusive quantifier-free logic into the exclusive notation that take these modifications into account and define a notion of logical equivalence suitable for assessing these translations.
Military Technology and Sample Selection Bias
Authors: Fourie Johan , Inwood Kris , Mariotti Martine
Published: June 2020

Military enlistment is highly selective for reasons of both labor demand and supply. An early-twentieth-century evolution of military technology that shifted the demand for workers of different stature illustrates the importance of labor demand beyond the commonly discussed influences originating with labor supply. English-born soldiers in the Anglo-Boer War (1899–1902) were taller, on average, than those of World War I (1914–18), yet these differences cannot be attributed to standard of living or business cycle influences on the labor market. Rather, we argue, the mechanization and bureaucratization of warfare increased the relative value of shorter people permitting a decline in the average height of soldiers. Technological change over the period of these two wars affected labor demand in a way that must be recognized before using this evidence to test hypotheses about changes in population health.
Earth’s Core Is in the Hot Seat
Authors: Duncombe Jenessa
Published: June 2020

How old is Earth’s inner core? High-pressure and high-temperature experiments suggest that our planet’s inner furnace may be much younger than expected.
Electron Density near Enceladus Shows Orbital Variation
Authors: Rehnberg Morgan
Published: June 2020

The electron density peaks well after the activity of the moon’s distinctive south polar ice plume reaches its maximum, but the cause of the lag remains puzzling.
Slow Earthquakes Illuminating Interplate Coupling Heterogeneities in Subduction Zones
Authors: Baba Satoru , Takemura Shunsuke , Obara Kazushige , Noda Akemi
Published: June 2020

Slow earthquakes are mainly distributed in the vicinity of seismogenic zones of megathrust earthquakes and relationships between both types of earthquakes are expected. We examined the activity of very low frequency earthquakes (VLFEs), classified as one type of slow earthquake, around Japan because they have the potential to clarify detailed spatiotemporal slip behaviors at the plate boundaries. The distribution of the shallow VLFE activity rate is heterogeneous along trench axes and exhibits an anticorrelation relationship with the spatial distribution of the interplate coupling ratio, whereas deep VLFEs are distributed only in weakly coupled areas, and the spatial variation of the activity rate is small. Furthermore, VLFEs are mainly hosted by low seismic velocity anomalies. Thus, slow earthquakes can be triggered by decreased effective stress due to the high pore fluid pressure within regions with weak interplate coupling, and their activity can be an indicator of interplate slip behavior.
The Reversal Indian Ocean Waters
Authors: Liang Linlin , Xue Huijie
Published: June 2020

The Reversal Indian Ocean Waters (RIOWs), carried by flows in a direction opposite to the Indonesian Throughflow (ITF), is investigated in the Lagrangian framework using the simulative results of a high‐resolution western Pacific and northern Indian Oceans Model (PIOM). The results suggest that the RIOWs have two sources: They are the Australian Northwest Shelf Inflow linking with the Leeuwin UnderCurrent (LUC) along with the previously identified South Java Coastal Undercurrent (SJCU). After entering the Indonesian seas, the RIOWs mix with other water masses and tend to make waters in the Indonesian seas cooler, saltier, and denser. Ultimately, about half of the RIOWs return to the Indian Ocean by joining the ITF, and the other half enter the Pacific Ocean and contribute to the North Equatorial CounterCurrent (NECC) and the North Intermediate CounterCurrent (NICC).
Volcano‐Wide Deformation After the 2017 Erta Ale Dike Intrusion, Ethiopia, Observed With Radar Interferometry
Authors: Xu Wenbin , Xie Lei , Aoki Yosuke , Rivalta Eleonora , Jónsson Sigurjón
Published: June 2020

Erta Ale Volcano erupted on 16 January 2017 in a difficult‐to‐access terrain in the Erta Ale volcanic range in Ethiopia. Like many other rifting ridge volcanoes, little is known about the properties of the deep magma plumbing system. Here, we analyze interferometric synthetic aperture radar data from different satellites between late January 2017 and May 2019 to study the ground deformation after the start of the intrusion to infer the possible geometry and volume change of the magma reservoir that fed the eruption. We identified volcano‐wide subsidence of up to 9 cm and horizontal contraction of up to ~5 cm that extend from Erta Ale to neighboring volcanoes. The modeling results suggest that an off‐rift NE‐SW elongated mid‐crustal source is required to explain the observed volcano‐wide deformation, but the depth is poorly constrained and the shape is complex. We suggest the presence of vertical interactions between stacked mid‐crustal magma sources. Our study demonstrates that a considerable volume of melt could have been stored in mid‐crustal magma reservoirs within the slow‐spreading Erta Ale Ridge to facilitate recent volcanic activity.
Impact of Shoaling Ocean Surface Waves on Wind Stress and Drag Coefficient in Coastal Waters: 1. Uniform Wind
Authors: Chen Xuanyu , Hara Tetsu , Ginis Isaac
Published: June 2020

This study investigates the impact of shoaling wind waves on the drag coefficient in coastal waters. The shoaling wave spectrum is simulated using the WAVEWATCH III (WW3) model with shallow water physics. The high‐frequency part (spectral tail), which is unresolved in the wave model, is empirically parameterized as a function of wind speed. The full wave spectrum is then used to estimate the sea‐state‐dependent wind stress and drag coefficient. Shoaling wind waves are simulated on a sloped bottom under the idealized steady uniform wind. Experimental wind speed spans from 10 to 65 m/s, and the bottom slope is varied from 1:100 to 1:2,000. Our results show that as water depth decreases, the drag coefficient increases gradually to a peak value and then rapidly reduces compared to the deep water value. The maximum Cd value occurs roughly where depth‐induced wave breaking starts. The magnitude of Cd enhancement is more significant on a steeper slope and can reach 40%. This Cd enhancement is mainly due to steepening of waves and reduction of the wave phase speed during the shoaling. Our results also suggest significantly larger variability of Cd at a given wind speed in finite‐depth waters than in deep water.
The Southern Hemisphere Minor Sudden Stratospheric Warming in September 2019 and its Predictions in S2S Models
Authors: Rao Jian , Garfinkel Chaim I. , White Ian P. , Schwartz Chen
Published: June 2020

A minor sudden stratospheric warming (SSW) happened in September 2019 in the Southern Hemisphere (SH) with winds at 10 hPa, 60°S reaching their minimum value on 18 September. Using multiple data sets and real‐time predictions from 11 subseasonal to seasonal (S2S) models, the evolution, favorable conditions, and predictability for this SSW event are explored. The September 2019 SSW happened during several favorable conditions, including easterly equatorial quasi‐biennial oscillation (QBO) winds at 10 hPa, solar minimum, positive Indian Ocean Dipole (IOD) sea surface temperatures (SST), warm SST anomalies in the central Pacific, and a blocking high near the Antarctic Peninsula. With these favorable initial and boundary conditions, the predictive limit to this SSW is around 18 days in some S2S models, and more than 50% of the ensemble members forecast the zonal wind deceleration in reforecasts initialized around 29 August. A vortex slowdown is evident in some initializations from around 22 August, but with a forecast‐reanalysis pattern correlation %3C0.5, while initializations later than 29 August capture the wavelike pattern in the troposphere and the subsequent stratospheric evolution. The ensemble spread in the magnitude of the vortex deceleration during the SSW is mainly explained by the ensemble spread in the magnitude of upward propagation of waves in the troposphere and in the stratosphere, with an underestimated tropospheric wave amplitude leading to a too‐small deceleration of the vortex. The September 2019 SH SSW did not show a near‐instantaneous downward impact on the tropospheric southern annular mode (SAM) in late September and early October 2019. The Australian drought and hot weather in September possibly associated with the positive IOD might have been exacerbated by the negative SAM in October and later months due to the weak stratospheric polar vortex. However, models tend to forecast a near‐instantaneous tropospheric response to the SSW.
On the Regional Variability of dB/dt and Its Significance to GIC
Authors: Dimmock A. P. , Rosenqvist L. , Welling D. T. , Viljanen A. , Honkonen I. , Boynton R. J. , Yordanova E.
Published: June 2020

Faraday's law of induction is responsible for setting up a geoelectric field due to the variations in the geomagnetic field caused by ionospheric currents. This drives geomagnetically induced currents (GICs) which flow in large ground‐based technological infrastructure such as high‐voltage power lines. The geoelectric field is often a localized phenomenon exhibiting significant variations over spatial scales of only hundreds of kilometers. This is due to the complex spatiotemporal behavior of electrical currents flowing in the ionosphere and/or large gradients in the ground conductivity due to highly structured local geological properties. Over some regions, and during large storms, both of these effects become significant. In this study, we quantify the regional variability of dB/dt using closely placed IMAGE stations in northern Fennoscandia. The dependency between regional variability, solar wind conditions, and geomagnetic indices are also investigated. Finally, we assess the significance of spatial geomagnetic variations to modeling GICs across a transmission line. Key results from this study are as follows: (1) Regional geomagnetic disturbances are important in modeling GIC during strong storms; (2) dB/dt can vary by several times up to a factor of three compared to the spatial average; (3) dB/dt and its regional variation is coupled to the energy deposited into the magnetosphere; and (4) regional variability can be more accurately captured and predicted from a local index as opposed to a global one. These results demonstrate the need for denser magnetometer networks at high latitudes where transmission lines extending hundreds of kilometers are present.
Generalized Sub‐Gaussian Processes: Theory and Application to Hydrogeological and Geochemical Data
Authors: Siena Martina , Guadagnini Alberto , Bouissonnié Arnaud , Ackerer Philippe , Daval Damien , Riva Monica
Published: June 2020

We start from the well‐documented scale dependence displayed by the probability distribution and associated statistical moments of a variety of hydrogeological and soil science variables and their spatial or temporal increments. These features can be captured by a Generalized Sub‐Gaussian (GSG) model, according to which a given variable, Y, is subordinated to a (typically spatially correlated) Gaussian random field, G, through a subordinator, U. This study extends the theoretical framework originally proposed by Riva et al. (2015, 10.1002/2015WR016998) to include the possibility of selecting a general form of the subordinator, thus enhancing the flexibility of the GSG framework for data interpretation and modeling. Analytical expressions for the GSG process associated with lognormal, Pareto, and Gamma subordinator distributions are then derived. We demonstrate the ability of the GSG modeling framework to capture the way key features of the statistics associated with two data sets transition across scales. The latter correspond to variables, which are typical of a geochemical and a hydrogeological setting, that is, (i) data characterizing the micrometer‐scale surface roughness of a crystal of calcite, collected within a laboratory‐scale setting, resulting from induced mineral dissolution, and (ii) a vertical distribution of decimeter‐scale porosity data, collected along a deep kilometer‐scale borehole within a sandstone formation and typically used in hydrogeological and geophysical characterization of aquifer systems. The theoretical developments and the successful applications of the approach we propose provide a unique framework within which one can interpret a broad range of scaling behaviors displayed by a variety of Earth and environmental variables in various scenarios.
Amyloid, tau, and astrocyte pathology in autosomal-dominant Alzheimer’s disease variants: AβPParc and PSEN1DE9
Authors: Lemoine Laetitia , Gillberg Per-Göran , Bogdanovic Nenad , Nennesmo Inger , Saint-Aubert Laure , Viitanen Matti , Graff Caroline , Ingelsson Martin , Nordberg Agneta
Published: June 2020

Autosomal-dominant Alzheimer’s disease (ADAD) may be associated with atypical amyloid beta deposits in the brain. In vivo amyloid imaging using 11C-Pittsburgh compound B (PiB) tracer has shown differences in binding between brains from ADAD and sporadic Alzheimer’s disease (sAD) patients. To gain further insight into the various pathological characteristics of these genetic variants, we performed large frozen hemisphere autoradiography and brain homogenate binding assays with 3H-PiB, 3H-MK6240-3H-THK5117, and 3H-deprenyl for detection of amyloid fibrils, tau depositions, and activated astrocytes, respectively, in two AβPParc mutation carriers, one PSEN1ΔE9 mutation carrier, and three sAD cases. The results were compared with Abeta 40, Abeta 42, AT8, and GFAP immunostaining, respectively, as well as with Congo red and Bielschowsky. PiB showed a very low binding in AβPParc. A high binding was observed in PSEN1ΔE9 and in sAD tissues but with different binding patterns. Comparable 3H-THK5117 and 3H-deprenyl brain homogenate binding was observed for AβPParc, PSEN1ΔE9, and sAD, respectively. Some differences were observed between 3H-MK6240 and 3H-THK5117 in ADAD. A positive correlation between 3H-deprenyl and 3H-THK5117 binding was observed in AβPParc, while no such correlation was found in PSEN1ΔE9 and sAD. Our study demonstrates differences in the properties of the amyloid plaques between two genetic variants of AD and sAD. Despite the lack of measurable amyloid fibrils by PiB in the AβPParc cases, high regional tau and astrocyte binding was observed. The lack of correlation between 3H-deprenyl and 3H-THK5117 binding in PSEN1ΔE9 and sAD in contrast of the positive correlation observed in the AβPParc cases suggest differences in the pathological cascade between variants of AD that warrant further exploration in vivo.
Axitinib plus immune checkpoint inhibitor: evidence- and expert-based consensus recommendation for treatment optimisation and management of related adverse events
Authors: Grünwald Viktor , Voss Martin H. , Rini Brian I. , Powles Thomas , Albiges Laurence , Giles Rachel H. , Jonasch Eric
Published: June 2020

With the recent approval of the combinations of axitinib with the immune checkpoint inhibitor (ICI) pembrolizumab or avelumab for first-line treatment of advanced renal cell carcinoma, guidance on how to distinguish between immune-related adverse events (AEs) caused by ICI versus axitinib-related AEs is necessary to optimise therapy with axitinib–ICI combinations. The recommendations here are based on (1) systematic review of published evidence, (2) discussion among experts in the field and (3) a survey to obtain expert consensus on specific measures for therapy management with the combinations axitinib/avelumab and axitinib/pembrolizumab. The experts identified areas of AEs requiring unique management during treatment with axitinib–ICI combinations that were not covered by current recommendations. Diarrhoea, hepatic toxicity, fatigue and cardiovascular AEs were found to be applicable to such specialised management. Triage between immune-suppressive and supportive measures is a key component in therapy management. Clinical monitoring and experience with both classes of agents are necessary to manage this novel therapeutic approach. We focused on AEs with an overlap between axitinib and ICI therapy. Our recommendations address AE management of axitinib–ICI combinations with the aim to improve the safety of these therapies.
Control of fibroblast shape in sequentially formed 3D hybrid hydrogels regulates cellular responses to microenvironmental cues
Authors: Liu Han , Wu Mian , Jia Yuanbo , Niu Lele , Huang Guoyou , Xu Feng
Published: June 2020

Cell shape plays important roles in regulating cell behavior; however, independently controlling cell shape in three dimensions is a challenging undertaking, and how cell shape affects cellular responses to mechanical and biochemical cues in three dimensions remains unclear. Here, we present a hydrogel-based platform to control cell shape in three dimensions by using sequentially formed hybrid hydrogels consisting of collagen and alginate. By adjusting the cross-linking time of the alginate, we fixed the shape of NIH 3T3 fibroblasts at different spreading states. Then, we explored the influence of cell shape on the cell responses to microenvironmental cues by using cardiac fibroblasts (CFs) as model cells. We found that the spreading state of the CFs influences their responses to both mechanical (i.e., matrix stiffness) and biochemical (i.e., transforming growth factor-β1 (TGF-β1)) cues in three dimensions. Additional experiments revealed that integrin β1 in focal adhesions and Smad2/3 are involved in mediating the cell shape-dependent responses of CFs to matrix stiffness and TGF-β1 cues, respectively. This work represents the first step in understanding how cell shape influences cell responses to mechanical and biochemical cues in three dimensions and can be instructive for developing novel approaches to target cell shape regulation for treating fibrosis and other diseases.
Parity-time symmetry in wavelength space within a single spatial resonator
Authors: Zhang Jiejun , Li Lingzhi , Wang Guangying , Feng Xinhuan , Guan Bai-Ou , Yao Jianping
Published: June 2020

We show a parity-time (PT) symmetric microwave photonic system in the optical wavelength space within a single spatial resonator, in which the gain and loss modes can perfectly overlay spatially but are distinguishable in the designated parameter space. To prove the concept, a PT-symmetric optoelectronic oscillator (OEO) in the optical wavelength space is implemented. The OEO has a single-loop architecture, with the microwave gain and loss modes carried by two optical wavelengths to form two mutually coupled wavelength-space resonators. The operation of PT symmetry in the OEO is verified by the generation of a 10-GHz microwave signal with a low phase noise of −129.3 dBc/Hz at 10-kHz offset frequency and small sidemodes of less than −66.22 dBc/Hz. Compared with a conventional spatial PT-symmetric system, a PT-symmetric system in the wavelength space features a much simpler configuration, better stability and greater resilience to environmental interferences.
Macromolecular and electrical coupling between inner hair cells in the rodent cochlea
Authors: Jean Philippe , Anttonen Tommi , Michanski Susann , de Diego Antonio M. G. , Steyer Anna M. , Neef Andreas , Oestreicher David , Kroll Jana , Nardis Christos , Pangršič Tina , Möbius Wiebke , Ashmore Jonathan , Wichmann Carolin , Moser Tobias
Published: June 2020

Inner hair cells (IHCs) are the primary receptors for hearing. They are housed in the cochlea and convey sound information to the brain via synapses with the auditory nerve. IHCs have been thought to be electrically and metabolically independent from each other. We report that, upon developmental maturation, in mice 30% of the IHCs are electrochemically coupled in ‘mini-syncytia’. This coupling permits transfer of fluorescently-labeled metabolites and macromolecular tracers. The membrane capacitance, Ca2+-current, and resting current increase with the number of dye-coupled IHCs. Dual voltage-clamp experiments substantiate low resistance electrical coupling. Pharmacology and tracer permeability rule out coupling by gap junctions and purinoceptors. 3D electron microscopy indicates instead that IHCs are coupled by membrane fusion sites. Consequently, depolarization of one IHC triggers presynaptic Ca2+-influx at active zones in the entire mini-syncytium. Based on our findings and modeling, we propose that IHC-mini-syncytia enhance sensitivity and reliability of cochlear sound encoding.
Unlocking the passivation nature of the cathode–air interfacial reactions in lithium ion batteries
Authors: Zou Lianfeng , He Yang , Liu Zhenyu , Jia Haiping , Zhu Jian , Zheng Jianming , Wang Guofeng , Li Xiaolin , Xiao Jie , Liu Jun , Zhang Ji-Guang , Chen Guoying , Wang Chongmin
Published: June 2020

It is classically well perceived that cathode–air interfacial reactions, often instantaneous and thermodynamic non-equilibrium, will lead to the formation of interfacial layers, which subsequently, often vitally, control the behaviour and performance of batteries. However, understanding of the nature of cathode–air interfacial reactions remain elusive. Here, using atomic-resolution, time-resolved in-situ environmental transmission electron microscopy and atomistic simulation, we reveal that the cathode–water interfacial reactions can lead to the surface passivation, where the resultant conformal LiOH layers present a critical thickness beyond which the otherwise sustained interfacial reactions are arrested. We rationalize that the passivation behavior is dictated by the Li+-water interaction driven Li-ion de-intercalation, rather than a direct cathode–gas chemical reaction. Further, we show that a thin disordered rocksalt layer formed on the cathode surface can effectively mitigate the surface degradation by suppressing chemical delithiation. The established passivation paradigm opens new venues for the development of novel high-energy and high-stability cathodes.
Fetal electrocardiograms, direct and abdominal with reference heartbeat annotations
Authors: Matonia Adam , Jezewski Janusz , Kupka Tomasz , Jezewski Michał , Horoba Krzysztof , Wrobel Janusz , Czabanski Robert , Kahankowa Radana
Published: June 2020

Monitoring fetal heart rate (FHR) variability plays a fundamental role in fetal state assessment. Reliable FHR signal can be obtained from an invasive direct fetal electrocardiogram (FECG), but this is limited to labour. Alternative abdominal (indirect) FECG signals can be recorded during pregnancy and labour. Quality, however, is much lower and the maternal heart and uterine contractions provide sources of interference. Here, we present ten twenty-minute pregnancy signals and 12 five-minute labour signals. Abdominal FECG and reference direct FECG were recorded simultaneously during labour. Reference pregnancy signal data came from an automated detector and were corrected by clinical experts. The resulting dataset exhibits a large variety of interferences and clinically significant FHR patterns. We thus provide the scientific community with access to bioelectrical fetal heart activity signals that may enable the development of new methods for FECG signals analysis, and may ultimately advance the use and accuracy of abdominal electrocardiography methods.
The Oldest Highlands of Mars May Be Massive Dust Fallout Deposits
Authors: Rodriguez J. Alexis P. , Dobrea Eldar Noe , Kargel Jeffrey S. , Baker V. R. , Crown David A. , Webster Kevin D. , Berman Daniel C. , Wilhelm Mary Beth , Buckner Denise
Published: June 2020

The oldest terrains of Mars are cratered landscapes, in which extensive valleys and basins are covered by ubiquitous fluvial plains. One current paradigm maintains that an impact-generated megaregolith underlies these sediments. This megaregolith was likely largely generated during the Early Noachian (~4.1 to ~3.94 Ga) when most Martian impact basins formed. We examined the geologic records of NW Hellas and NW Isidis, which include this epoch’s most extensive circum-basin outcrops. Here, we show that these regions include widespread, wind-eroded landscapes, crater rims eroded down by several hundred meters, pitted plains, and inverted fluvial and crater landforms. These surfaces exhibit few fresh craters, indicating geologically recent wind erosion. The deep erosion, topographic inversions, and an absence of dunes on or near talus across these regions suggest that sediments finer than sand compose most of these highland materials. We propose that basin-impact-generated hurricane-force winds created sediment-laden atmospheric conditions, and that muddy rains rapidly settled suspended sediments to construct extensive Early Noachian highlands. The implied high abundance of fine-grained sediments before these impacts suggests large-scale glacial silt production and supports the previously proposed Noachian “icy highlands” hypothesis. We suggest that subglacial meltwater interactions with the sedimentary highlands could have promoted habitability, particularly in clay strata.
Resilience of Urban Transport Network-of-Networks under Intense Flood Hazards Exacerbated by Targeted Attacks
Authors: Yadav Nishant , Chatterjee Samrat , Ganguly Auroop R.
Published: June 2020

Natural hazards including floods can trigger catastrophic failures in interdependent urban transport network-of-networks (NoNs). Population growth has enhanced transportation demand while urbanization and climate change have intensified urban floods. However, despite the clear need to develop actionable insights for improving the resilience of critical urban lifelines, the theory and methods remain underdeveloped. Furthermore, as infrastructure systems become more intelligent, security experts point to the growing threat of targeted cyber-physical attacks during natural hazards. Here we develop a hypothesis-driven resilience framework for urban transport NoNs, which we demonstrate on the London Rail Network (LRN). We find that topological attributes designed for maximizing efficiency rather than robustness render the network more vulnerable to compound natural-targeted disruptions including cascading failures. Our results suggest that an organizing principle for post-disruption recovery may be developed with network science principles. Our findings and frameworks can generalize to urban lifelines and more generally to real-world spatial networks.
Quantum stochastic transport along chains
Authors: Shapira Dekel , Cohen Doron
Published: June 2020

The spreading of a particle along a chain, and its relaxation, are central themes in statistical and quantum mechanics. One wonders what are the consequences of the interplay between coherent and stochastic transitions. This fundamental puzzle has not been addressed in the literature, though closely related themes were in the focus of the Physics literature throughout the last century, highlighting quantum versions of Brownian motion. Most recently this question has surfaced again in the context of photo-synthesis. Here we consider both an infinite tight-binding chain and a finite ring within the framework of an Ohmic master equation. With added disorder it becomes the quantum version of the Sinai-Derrida-Hatano-Nelson model, which features sliding and delocalization transitions. We highlight non-monotonic dependence of the current on the bias, and a counter-intuitive enhancement of the effective disorder due to coherent hopping.
Presence of serum amyloid A3 in mouse plasma is dependent on the nature and extent of the inflammatory stimulus
Authors: Chait Alan , den Hartigh Laura J. , Wang Shari , Goodspeed Leela , Babenko Ilona , Altemeier William A. , Vaisar Tomas
Published: June 2020

Serum amyloid A3 (Saa3) derives mainly from extrahepatic tissue and is not detected in plasma from moderately inflamed obese mice. In contrast, it is present in plasma from mice acutely inflamed by injection of high dose of lipopolysaccharide (LPS). To reconcile these differences, we evaluated whether different acute inflammatory stimuli could affect the presence of Saa3 in plasma. Saa3 appeared dose dependently in plasma after LPS injection. In contrast, only very low levels were detected after sterile inflammation with silver nitrate despite levels of Saa1 and Saa2 being comparable to high dose LPS. Saa3 was not detected in plasma following casein administration. Although most Saa3 was found in HDL, a small amount was not lipoprotein associated. Gene expression and proteomic analysis of liver and adipose tissue suggested that a major source of Saa3 in plasma after injection of LPS was adipose tissue rather than liver. We conclude that Saa3 only appears in plasma after induction of acute inflammation by some but not all inflammatory stimuli. These findings are consistent with the observation that Saa3 is not detectable in plasma in more moderate chronic inflammatory states such as obesity.
Label-free metabolic biomarkers for assessing valve interstitial cell calcific progression
Authors: Tandon Ishita , Kolenc Olivia I. , Cross Delaney , Vargas Isaac , Johns Shelby , Quinn Kyle P. , Balachandran Kartik
Published: June 2020

Calcific aortic valve disease (CAVD) is the most common form of valve disease where the only available treatment strategy is surgical valve replacement. Technologies for the early detection of CAVD would benefit the development of prevention, mitigation and alternate therapeutic strategies. Two-photon excited fluorescence (TPEF) microscopy is a label-free, non-destructive imaging technique that has been shown to correlate with multiple markers for cellular differentiation and phenotypic changes in cancer and wound healing. Here we show how specific TPEF markers, namely, the optical redox ratio and mitochondrial fractal dimension, correlate with structural, functional and phenotypic changes occurring in the aortic valve interstitial cells (VICs) during osteogenic differentiation. The optical redox ratio, and fractal dimension of mitochondria were assessed and correlated with gene expression and nuclear morphology of VICs. The optical redox ratio decreased for VICs during early osteogenic differentiation and correlated with biological markers for CAVD progression. Fractal dimension correlated with structural and osteogenic markers as well as measures of nuclear morphology. Our study suggests that TPEF imaging markers, specifically the optical redox ratio and mitochondrial fractal dimension, can be potentially used as a tool for assessing early CAVD progression in vitro.
Molecular genetic and geochemical assays reveal severe contamination of drinking water reservoirs at the ancient Maya city of Tikal
Authors: Lentz David L. , Hamilton Trinity L. , Dunning Nicholas P. , Scarborough Vernon L. , Luxton Todd P. , Vonderheide Anne , Tepe Eric J. , Perfetta Cory J. , Brunemann James , Grazioso Liwy , Valdez Fred , Tankersley Kenneth B. , Weiss Alison A.
Published: June 2020

Understanding civilizations of the past and how they emerge and eventually falter is a primary research focus of archaeological investigations because these provocative data sets offer critical insights into long-term human behavior patterns, especially in regard to land use practices and sustainable environmental interactions. The ancient Maya serve as an intriguing example of this research focus, yet the details of their spectacular emergence in a tropical forest environment followed by their eventual demise have remained enigmatic. Tikal, one of the foremost of the ancient Maya cities, plays a central role in this discussion because of its sharp population decline followed by abandonment during the late 9th century CE. Our results, based on geochemical and molecular genetic assays on sediments from four of the main reservoirs, reveal that two of the largest reservoirs at Tikal, essential for the survival of the city during the dry seasons, were contaminated with high levels of mercury, phosphate and cyanobacteria known to produce deadly toxins. Our observations demonstrate severe pollution problems at a time when episodes of climatic aridity were prevalent. This combination of catastrophic events clearly threatened the sustainability of the city and likely contributed to its abandonment.
Induced tolerance to abiotic and biotic stresses of broccoli and Arabidopsis after treatment with elicitor molecules
Authors: Venegas-Molina Jhon , Proietti Silvia , Pollier Jacob , Orozco-Freire Wilson , Ramirez-Villacis Darío , Leon-Reyes Antonio
Published: June 2020

The plant hormones salicylic acid (SA) and jasmonic acid (JA) regulate defense mechanisms capable of overcoming different plant stress conditions and constitute distinct but interconnected signaling pathways. Interestingly, several other molecules are reported to trigger stress-specific defense responses to biotic and abiotic stresses. In this study, we investigated the effect of 14 elicitors against diverse but pivotal types of abiotic (drought) and biotic (the chewing insect Ascia monuste, the hemibiotrophic bacterium Pseudomonas syringae DC 3000 and the necrotrophic fungus Alternaria alternata) stresses on broccoli and Arabidopsis. Among the main findings, broccoli pre-treated with SA and chitosan showed the highest drought stress recovery in a dose-dependent manner. Several molecules led to increased drought tolerance over a period of three weeks. The enhanced drought tolerance after triggering the SA pathway was associated with stomata control. Moreover, methyl jasmonate (MeJA) reduced A. monuste insect development and plant damage, but unexpectedly, other elicitors increased both parameters. GUS reporter assays indicated expression of the SA-dependent PR1 gene in plants treated with nine elicitors, whereas the JA-dependent LOX2 gene was only expressed upon MeJA treatment. Overall, elicitors capable of tackling drought and biotrophic pathogens mainly triggered the SA pathway, but adversely also induced systemic susceptibility to chewing insects. These findings provide directions for potential future in-depth characterization and utilization of elicitors and induced resistance in plant protection.
Proteomics pinpoints alterations in grade I meningiomas of male versus female patients
Authors: Silva Janaína M. , Wippel Helisa H. , Santos Marlon D. M. , Verissimo Denildo C. A. , Santos Renata M. , Nogueira Fábio C. S. , Passos Gustavo A. R. , Sprengel Sergio L. , Borba Luis A. B. , Carvalho Paulo C. , Fischer Juliana de S. da G.
Published: June 2020

Meningiomas are among the most common primary tumors of the central nervous system (CNS) and originate from the arachnoid or meningothelial cells of the meninges. Surgery is the first option of treatment, but depending on the location and invasion patterns, complete removal of the tumor is not always feasible. Reports indicate many differences in meningiomas from male versus female patients; for example, incidence is higher in females, whereas males usually develop the malignant and more aggressive type. With this as motivation, we used shotgun proteomics to compare the proteomic profile of grade I meningioma biopsies of male and female patients. Our results listed several differentially abundant proteins between the two groups; some examples are S100-A4 and proteins involved in RNA splicing events. For males, we identified enriched pathways for cell-matrix organization and for females, pathways related to RNA transporting and processing. We believe our findings contribute to the understanding of the molecular differences between grade I meningiomas of female and male patients.
Physico-chemical study of complexation of silver ion (Ag+) by macrocyclic molecules (hexa-Helicenes) based on statistical physics theory: new description of a cancer drug
Authors: Ben Yahia Manel , Ben Yahia Mohamed
Published: June 2020

In recent papers, it is found that the silver-[6]Helicene complex can be used as a cancer drug but the interaction silver-hexaHelicene has not yet proven. The idea of this paper is to investigate the complexation process of the [6]Helicene by the silver metal (Ag+) using three types of adsorbates. Indeed, the adsorption of silver chloride, silver nitrate and silver sulfide into the sensor films deposited on the QCM electrode are measured at three temperatures (293–333 K). Films of the [6]Helicene were deposited on the QCM resonators using spin coating method in order to obtain uniform and homogenous sensor surface. Experimental results indicated that the [6]Helicene can form a stable complex with the silver ion and that the AgCl is the appropriate adsorbate for the complexation achievement. Actually, an advanced modeling analysis by means of statistical physics adsorption models is applied to explore the new vision of the complextion system. The values of the models parameters are deduced from fitting the experimental data with the developed models. They result in confirming the experimental findings by comparing the complexation energies of the three examined systems. In particular, for the silver nitrate, the Van-der-Waals parameters explained the isotherms drop at high concentration through the lateral interactions between the adsorbates. The adsorption energies analysis showed the highest interaction AgCl-[6]Helicene. Density functional theory (DFT) simulations showed that chemical bonds take place during the adsorption of silver chloride on hexaHelicene which confirms that the [6]Helicene can function as a chiral molecular tweezer of the univalent cationic silver.
Novel polymer coating for chemically absorbing CO2 for safe Li-ion battery
Authors: Daigle Jean-Christophe , Asakawa Yuichiro , Perea Alexis , Dontigny Martin , Zaghib Karim
Published: June 2020

Gas evolution in Li-ion batteries remains a barrier for the implementation of high voltage materials in a pouch cell format; the inflation of the pouch cell is a safety issue that can cause battery failure. In particular, for manganese-based materials employed for fabricating cathodes, the dissolution of Mn2+ in the electrolyte can accelerate cell degradation, and subsequently gas evolution, of which carbon dioxide (CO2) is a major component. We report on the utilization of a mixture of polymers that can chemically absorb the CO2, including the coating of aluminum foils, which serve as trapping sheets, introduced into two Ah pouch cells—based on a LiMnFePO4 (cathode) and a Li4Ti5O12 (anode). The pouch cells with trapping sheets experienced only an 8.0 vol% inflation (2.7 mmol CO2 per gram of polymers) as opposed to the 40 vol% inflation for the reference sample. Moreover, the cells were cycled for 570 cycles at 1 C and 45 °C before reaching 80% of their retention capacity.
TET1 Deficiency Impairs Morphogen-free Differentiation of Human Embryonic Stem Cells to Neuroectoderm
Authors: Li Hanqin , Hu Zhixing , Jiang Houbo , Pu Jiali , Selli Ilana , Qiu Jingxin , Zhang Baorong , Feng Jian
Published: June 2020

The TET family of 5-methylcytosine (5mC) dioxygenases plays critical roles in development by modifying DNA methylation. Using CRISPR, we inactivated the TET1 gene in H9 human embryonic stem cells (hESCs). Mutant H9 hESCs remained pluripotent, even though the level of hydroxymethylcytosine (5hmC) decreased to 30% of that in wild-type cells. Neural differentiation induced by dual SMAD inhibitors was not significantly affected by loss of TET1 activity. However, in a morphogen-free condition, TET1 deficiency significantly reduced the generation of NESTIN+SOX1+ neuroectoderm cells from 70% in wild-type cells to 20% in mutant cells. This was accompanied by a 20-fold reduction in the expression level of PAX6 and a significant decrease in the amount of 5hmC on the PAX6 promoter. Overexpression of the TET1 catalytic domain in TET1-deficient hESCs significantly increased 5hmC levels and elevated PAX6 expression during differentiation. Consistent with these in vitro data, PAX6 expression was significantly decreased in teratomas formed by TET1-deficient hESCs. However, TET1 deficiency did not prevent the formation of neural tube-like structures in teratomas. Our results suggest that TET1 deficiency impairs the intrinsic ability of hESCs to differentiate to neuroectoderm, presumably by decreasing the expression of PAX6, a key regulator in the development of human neuroectoderm.