bluuebunny/crossref_metadata_2025 huggingface dataset:
Bridging Biodiversity and Health: The Global Biodiversity Information Facility’s initiative on open data on vectors of human diseases
Authors: Shimabukuro Paloma , Groom Quentin , Fouque Florence , Campbell Lindsay , Chareonviriyaphap Theeraphap , Etang Josiane , Manguin Sylvie , Sinka Marianne , Schigel Dmitry , Ingenloff Kate
Published: April 2024

There is an increased awareness of the importance of data publication, data sharing, and open science to support research, monitoring and control of vector-borne disease (VBD). Here we describe the efforts of the Global Biodiversity Information Facility (GBIF) as well as the World Health Special Programme on Research and Training in Diseases of Poverty (TDR) to promote publication of data related to vectors of diseases. In 2020, a GBIF task group of experts was formed to provide advice and support efforts aimed at enhancing the coverage and accessibility of data on vectors of human diseases within GBIF. Various strategies, such as organizing training courses and publishing data papers, were used to increase this content. This editorial introduces the outcome of a second call for data papers partnered by the TDR, GBIF and GigaScience Press in the journal GigaByte. Biodiversity and infectious diseases are linked in complex ways. These links can involve changes from the microorganism level to that of the habitat, and there are many ways in which these factors interact to affect human health. One way to tackle disease control and possibly elimination, is to provide stakeholders with access to a wide range of data shared under the FAIR principles, so it is possible to support early detection, analyses and evaluation, and to promote policy improvements and/or development.
Assessment of Compliance and Welfare of Construction Workers at Selected Building Construction Project in Kathmandu: Implications for Labor Act Implementation
Authors: Bhattarai Subash Kumar , Dahal Diksha , Neupane Uttame
Published: April 2024

This study assesses compliance and welfare among construction workers at selected building construction projects in Kathmandu, examining implications for Labor Act implementation. Utilizing literature review and questionnaire surveys, data from 228 workers, with 99 in the sample, were analyzed. The questionnaire surveyed 31 special Labor Act provisions, employing dichotomous questions. Results show high worker awareness of rights under the Labor Act, notably regarding employer duties, non-discrimination, working hours, overtime, and safety. However, gaps exist in awareness regarding remuneration, transportation, and timely wage payment. Mann-Whitney U tests comparing male and female respondents revealed no statistically significant differences in scores, suggesting gender neutrality in compliance perceptions. Challenges in labor law enforcement, including insufficient mechanisms, resource constraints, and monitoring gaps, were identified. Recommendations include strengthening enforcement, enhancing awareness, capacity-building, and stakeholder collaboration. Continuous monitoring and evaluation are emphasized to ensure construction worker welfare in Kathmandu.
Pengusahaan Penambangan Minyak Bumi Pada Sumur Tua Oleh Masyarakat Kecamatan Kedewan Kabupaten Bojonegoro
Authors: Kushariyadi  , Gilang Muhammad Rido  , Tri Warcono Adi  , Nabila Andari  , Savira Putri Faiza
Published: April 2024

Untuk mengoptimalkan produksi minyak bumi secara nasional serta untuk meningkatkan tarap hidup dan kesejahteraan masyarakat dipandang perlu untuk mengeluarkan regulasi tentang pengelolaan dan pengusahaan minyak bumi pada sumur tua yang tersebar di wilayah lapangan minyak yang sudah tua. Sejalan dengan hal tersebut Pemerintah dalam hal ini Kementerian Pertambangan dan Energi menerbitkan Keputusan Menteri Pertambangan dan Energi No. 1285K/30/MPE/1996 yang kemudian diperbaui dengan Peraturan Menteri Energi dan Sumber Daya Mineral No. 01 Tahun 2008 tentang Pedoman Pengusahaan Pertambangan Minyak Bumi pada Sumur Tua, dapat diartikan sebagai perwujudan dari makna yang terkandung dalam pasal 33 UUD 1945, merupakan angin segar bagi Pemerintah Daerah yang mempunyai banyak sumur tua, karena Peraturan Menteri Energi dan Sumber Daya Mineral No. 01 Tahun 2008 tersebut memberikan jalan dan harapan bagi meningkatnya APBD dan kesejahteraan rakyat, dengan keikut sertaan KUD atau BUMD memproduksi minyak bumi pada sumur tua yang ada di wilayahnya. Kecamatan Kedewan, Kabupaten Bojonegoro merupakan salah satu wilayah di Propinsi Jawa Timur yang merupakan daerah penghasil migas yang masih aktip hingga saat ini. Lapangan minyak yang ada di Kecamatan Kedewan, Kabupaten Bojonegoro merupakan lapangan Sumur Minyak Tua yang sudah diproduksi sejak jaman Belanda, sehingga produksinya sudah tidak maksimal. Potensi sumur tua minyak bumi yang ada tersebut masih dapat dikelola dan dimanfaatkan dengan penambangan secara tradisional dengan mengikutkan masyarakat setempat. Kegiatan pengusahaan sumur tua minyak bumi yang paling menonjol dan berhasil yang ada di wilayah kerja PT Pertamina EP Asset 4 Lapangan Cepu, khususnya yang ada di Desa-desa Kecamatan Kedewan, Kabupaten Bojonegoro, penambangan ini menggunakan teknologi sederhana dengan metode menimba sehingga relatif lebih ekonomis.
Cut-down Access to Avoid Vascular Complications During Transcatheter Aortic Valve Implantation
Authors: Martinelli Gian Luca
Published: April 2024

Objective: Vascular Complications (VCs) are independent predictors of mortality after Transcatheter Aortic Valve Implantation with Transfemoral Access (TF-TAVI) and remain an unsolved problem regardless of the Percutaneous (PC) or Surgical Cut-down (SC) access for patients with severe Aortic Valve Stenosis (AVS). The debate about the short- and long-term results, safety, risks of procedural complications and the complementary roles of SC and PC approaches is still open. We aim to show VCs in our series of patients submitted to TF-TAVI using a surgical-cutdown.

Methodsː Retrospective analysis of consecutive patients with symptomatic severe AVS receiving TF-TAVI. The accesses were studied by computed tomography and Echo Color Doppler. The STS score was <4 in 172 (66.4%), 4-8 in 72 (27.8%) and >8 in 15 (5.8%) patients. The outcomes were the incidence of VCs. SC procedures were applied by Edwards SAPIENTM 3 (Edwards Lifesciences, Irvine, CA, USA) BE device.

Resultsː We enrolled 259 patients, 244 (94.2%) underwent TF-TAVI with the SC approach. The mean patients’ age was 82 ± 2 (range: 58-99). Female patients were 160/259 (62%) and male 99/259 (38%). The mean fluoroscopic time was 22 minutes. The 30-day mortality rate was 0.77% (two deaths). Intraoperative VCs were 6 (2.3%) and 1 (0.4%) at 1-year follow-up. The ICU stay was one day, the median post-operative hospitalization was two days.

Conclusionː This study contributes to the debate about the advantages of the SC approach compared to PC according to the patients’ profile with AVS and proposes multicenter prospective trials, especially for a future TAVI use in young and low-risk patients.
Exploring the Intersection of Bodybuilding and Ramadan: Strategies for Maintaining Muscle Mass and Performance During Fasting
Authors: Hamlaoui Khaled
Published: April 2024

Ramadan, the ninth month of the Islamic lunar calendar, involves fasting from dawn until sunset as a spiritual practice. For individuals engaged in bodybuilding and fitness pursuits, Ramadan presents unique challenges and opportunities. This article reviews the scientific literature on the effects of Ramadan fasting on muscle physiology and performance, as well as strategies for optimizing bodybuilding goals during this period. It examines nutritional and training considerations to help individuals maintain muscle mass, strength and performance while observing Ramadan.
Impact Factor: Myths and Realities
Authors: Rogers L F
Published: April 2024

The Impact Factor was originally devised as an index of the quality of scientific journals and has since obtained mythical proportions. Authors select journals to which they submit their work on the basis of that journal’s Impact Factor. Medical school deans and administrators have adopted the Impact Factor as a means of judging the quality of the academic efforts of individual faculty, as well as the aggregate academic productivity of medical school departments. Departmental budgets have been based on the Impact Factor. There are serious questions as to the validity of using the Impact Factor for these purposes.
Breast Cancer in Women Under 40 Years: Preoperative Detection by Mammography
Authors: Muttarak M , Pojchamarnwiputh S , Chaiwun B
Published: April 2024

Introduction: This article assesses the diagnostic sensitivity of mammography in the preoperative detection of breast cancer in young women.

Materials and Methods: We retrospectively reviewed 1010 women with breast carcinoma between January 1996 and September 2002. The patients were identified from pathological reports. Of these, 237 women were below 40 years of age, accounting for 23.5% of all breast cancers. Only 76 of 237 patients had mammograms performed prior to surgery. Seventy-five of the 76 patients also had ultrasonography performed. Histological types were reviewed and the proportions of each type were compared with those found in a consecutive series of 773 breast carcinomas in women above 40 years of age seen during the same period in our hospital. The breast patterns, as seen on mammograms, were classified as follows: fatty, scattered fibroglandular, heterogeneously dense and homogeneously dense. Specific features of a mass, microcalcifications, architectural distortion and asymmetrical density were evaluated.

Results: Of the 76 patients who had mammograms performed prior to surgery, 81 cancers were found. The patients’ age ranged from 25 to 40 years, with a mean of 36.4 years. The breast parenchymal patterns were homogeneously dense in 6.6%, heterogeneously dense in 67.1% and had scattered fibroglandular density in 26.3%. Abnormal mammographical findings were present in 93.8%. The most common mammographical findings were mass in 60% and microcalcifications, with or without associated breast abnormality, in 28.7%. The most frequent tumour (82.7%) was invasive ductal carcinoma, which is not significantly different to those found in older women (P = 0.895). Ultrasonography showed solid masses in 73 patients and was negative in the other 2 patients.

Conclusion: Mammography is a useful imaging technique in providing preoperative detection and diagnosis of breast carcinoma in women below 40 years of age with clinical suspicion of malignancy. Mass and microcalcifications are the most common abnormal mammographical findings and invasive ductal carcinoma is the most common tumour found in our study.
Imaging of Acquired Immunodeficiency Syndrome (AIDS)
Authors: Corr P
Published: April 2024

Imaging plays an important role in the detection and characterisation of opportunistic infections and malignancies in patients with the acquired immunodeficiency syndrome (AIDS). The imaging features of opportunistic infections are often non-specific, but when examined in the context of CD4 levels will often allow a correct diagnosis to be made. It is important to be aware of specific syndromes such as lymphoproliferative disease and AIDS nephropathy. The radiologist is often the first clinician to suspect the possibility of human immunodeficiency virus (HIV) or AIDS in a patient’s diagnostic work-up and it is, therefore, important that radiologists are familiar with the imaging features of this disease and its complications.
Clinical Positron Emission Tomography Imaging—Current Applications
Authors: Goh A S W , Ng D C E
Published: April 2024

Positron emission tomography (PET) is an established imaging technique based on the use of short-lived radiotracers. The unique value of PET lies in the ability of various radiochemical compounds to serve as tracers for measuring specific metabolic processes in the body. This enables detection of the early biochemical anomalies that precede the structural changes seen on other imaging techniques. For decades, PET had remained essentially a research tool in academic institutions. However, in recent years, it has emerged as a vital clinical tool, particularly for cancer diagnosis and management. In this era of evidence-based medicine, the clinical applications of PET imaging have been subjected to intense evaluation, and its roles in oncology, neurology and cardiology have dominated nuclear medicine research and scientific publications in the past 5 to 8 years. This review article summarises the present status of the major clinical indications for PET scanning. The field is rapidly evolving and, with the recent advent of hybrid PET-CT scanners, new data continue to emerge, refining these clinical applications. Another important area of ongoing research is the development of new radio-labelled compounds for PET imaging.
Intracerebral Schwannoma—A Rare Cause of Epilepsy
Authors: Chng S M , Lim C C T , Seow W T
Published: April 2024

Introduction: We report a case of schwannoma occurring in an intra-axial location causing seizures.

Clinical Picture: A 13-year-old girl presented with a 4-month history of seizures. Preoperative computed tomography scan and magnetic resonance imaging revealed an enhancing right frontal lobe tumour with surrounding oedema.

Treatment: The patient underwent craniotomy and a well-circumscribed tumour was completely resected. Histology with immunohistochemistry confirmed the diagnosis of an intracerebral schwannoma.

Outcome: The patient made a complete recovery and was seizure-free at 1-year follow-up.

Conclusion: Intracerebral schwannomas are rare, benign tumours. They may mimic astrocytomas or malignant tumours, and it is important to differentiate them from other neoplasms with less favourable outcomes. The neuroimaging features are, however, non-specific and definitive diagnosis can only be made on histology.
Analisis Inovasi Pelayanan Akta Kelahiran Online
Authors: Karua Gusriani Arrang , Matasik Ade Lisa
Published: April 2024

This study aims to determine whether the Online Birth Certificate Service Innovation at the Departement of Population and Civil Registration of Tana Toraja Regency has been running well. The benefit of this research is that it can contribute ideas, information for the Partement of Population and Civil Registration of Tana Toraja Regency to improve service in the implementation of making online birth certificates. This research was conducted using qualitative methods with data collection techniques namely interviews, observation, and documentation. Data analysis shows that the birth certificate service innovation that is being carried out is service innovation in a new way in interacting whit the community whit birth certificate registration service through WhatsApp media sending complete files or requirements for making birth certificate to the Population and Civil Registration Office of Tana Toraja Regency. Although the public does not understand about making birth certificates online, most of the people participate in the online birth certificate service program which is implemented at the Office of Population and Civil Registration of Tana Toraja Regency
Analisis Strategi Promosi Dalam Meningkatkan Jumlah Peserta Didik Pada SMK Pati Di Rantelemo
Authors: Patadungan Ellyn , Bandaso Srysetyawanie
Published: April 2024

The purpose of this study was to determine the promotion strategy in increasing the number of students at SMK Pati Rantelemo. This research method uses a qualitative descriptive type of research that is to provide evidence of truth according to the theory and issues raised through observation, interviews and documentation. The types of data used are primary data and secondary data, then analyzed according to the theory of Milles, Huberman and Saldan, namely: data reduction, data presentation, and conclusions and verification. Based on the results of the research that has been done, it can be seen that the promotional strategy carried out by SMK Pati Rantelemo in increasing the number of students has been carried out as much as possible, using the concept of a promotional mix, namely Advertising which includes (billboards and brochures), Sales Promotion (free entry fees and registration fee), Individual Sales (all school members participate in promoting the school), Publicity/Community Relations which includes (holding outreach to nearby churches), and Direct Selling (listing the school's telephone number on brochures and banners).
Pengaruh Store Atmosphere Dan Word Of Mouth Terhadap Keputusan Pembelian Pada Labuana Resto & Cafe Makassar
Authors: Chandra Meliana , Sampe Ferdinandus , Tahendrika Abner
Published: April 2024

This study aims to analyze the influence of store atmosphere and word of mouth on purchasing decisions at LaBuana Resto & Cafe Makassar. This study uses quantitative methods with the number of respondents being 98 visitors at LaBuana Resto & Café Makassar. Data collection is done by distributing questionnaires. The results of the calculation of the Store atmosphere variable (X1) on average of 4.06 which means most respondents agree on the statement items store atmosphere. While the results of the variable (X2) Word of mouth on average of 4.16, which means that most of the respondents agree with the statement items. The results showed that store atmosphere and word of mouth had a significant effect on purchasing decisions at Labuan Cafe & Restaurant Makassar, as evidenced by a significant value of 0.000 > 0.05. This proves that the store atmosphere and word of mouth have an effect on purchasing decisions at LaBuana Resto & Cafe Makassar.
Pengaruh Human Relation Dan Lingkungan Kerja Terhadap Etos Kerja Karyawan Pada PT. Seafood Industrial Group (SIG) Asia Bitung
Authors: Hamisi Yusuf , Karamoy Tiffany S.
Published: April 2024

The purpose of this research is to find out how the influence of human relations variables and work environment variables partially and simultaneously on employee work ethic variables. This research is a type of descriptive research with a quantitative approach. Population is 230 production employees at PT. Seafood Industrial Group (GIS) Asia Bitung. Samples are 58 employees. Data analysis uses multiple linear regression. The results of research and discussion indicate that human relations or relations between humans and the work environment partially and overall have a significant impact on the work ethic of workers at PT . Seafood Industrial Group (SIG) Asia Bitung.
Development of Circular Economy in Agriculture in Hanoi, Vietnam
Authors:   Tuyen Pham, PhD student at the University of Economics and Business, Vietnam National University, Hanoi, Vietnam, Pham Tuyen
Published: April 2024

The introduction of circular economy principles into closed production systems is essential to address current socio-economic and ecological challenges efficiently. This approach not only saves costs, creates job opportunities, and fosters economic growth but also promotes the sustainable use of natural resources in agriculture. Transitioning to a circular economy model in agriculture contributes to achieving sustainable development goals. In Hanoi, Vietnam, sustainable agriculture development focuses on integrating natural processes and biological resources to enhance productivity while preserving the environment. Challenges persist in shifting from conventional to organic farming methods due to certification complexities and infrastructure limitations. Despite these hurdles, organic farming adoption is increasing, positively impacting agricultural productivity and biodiversity. The gradual expansion of certified organic agriculture in Hanoi indicates promising strides toward environmental conservation and economic development through a closed-loop agricultural system.
Piense en … MELANOMA NODULAR AMELANÓTICO
Authors: Boulet María Julia , Camardella Ileana Rosalía , Coletto Gianina Anabella
Published: April 2024

Granuloma piógeno: proliferación vascular capilar benigna, asociada a irritantes locales, trauma, infección, malformaciones vasculares preexistentes o medicación.

Edad más frecuente: infancia y adultos jóvenes.

Melanoma nodular amelanótico: el melanoma  nodular representa el 15-30% del total de los melanomas. La variante amelanótica se observa en el 2 al 8% de todos los melanomas, más frecuentemente en melanoma nodular. Edad y factores de riesgo: >50 años. Fototipo I, raza blanca, ausencia de nevos en el dorso.

Carcinoma de células de Merkel: neoplasia neuroendocrina rara y agresiva. Edad y factores de riesgo: 65 a 85 años, >sexo masculino. RUV, inmunosupresión y poliomavirus.
Elección múltiple: LESIONES HIPERPIGMENTADAS EN PIEL
Authors: Bazan Mariam Yisell , Gonella del Carril María de la Paz
Published: April 2024

Niña de 9 años procedente de Las Talitas, Tucumán, con antecedentes personales de hipoacusia bilateral y obesidad, consultó por presentar una dermatosis localizada en el rostro y la región inguinal de 3 meses de evolución, sin síntomas acompañantes.

Al examen físico se observaban máculas amarronadas, localizadas en la región palpebral bilateral, peribucal e inguinal.

Se solicitaron estudios complementarios incluyendo laboratorio que no evidenció datos significativos. En la dermatoscopia de las lesiones cutáneas se observaron glóbulos finos de color amarronados de disposición lineal y biopsia de piel de región inguinal en cuyo estudio histopatológico con tinción HyE informó un infiltrado inflamatorio en banda, que borró la unión dermoepidérmica, la degeneración vacuolar de los queratinocitos basales, cuerpos de civatte y los abundantes melanófagos cargados de pigmento.
Desenvolvimento do modelo de negócios e análise estratégica de uma microempresa do ramo alimentício artesanal
Authors: Vaz Letícia Pereira , Maria Robert Cruzoaldo , Longhini Tatielle Menolli
Published: April 2024

O presente estudo trata-se do desenvolvimento do Modelo de Negócios de uma Microempresa do setor de panificação artesanal e tem como objetivo utilizar o Modelo de Negócios, ferramenta utilizada para compreender a maneira de se entregar valor, observando o negócio pelo macro, para definir o futuro da empresa no mercado. Quanto a metodologia utilizada, a pesquisa se apresenta como descritiva, com abordagem qualitativa e obteve como método técnico o estudo de caso. Os dados foram coletados através de pesquisa documental, pesquisa-ação e análise de dados primários. Foram utilizadas as ferramentas Modelo de Negócios Canvas e análise estratégicas por SWOT que se mostraram bastante úteis, permitindo uma visão mais clara das distintas áreas da empresa. Mesmo com a limitação da ausência de dados sobre o setor do negócio, quando realizadas as análises dos quadros elaborados pelas ferramentas utilizadas, têm-se elaborações importantes para a Microempresa. Os objetivos esperados foram atingidos e a Microempresa tem espaço e meios para realizar seu crescimento.
Comprehensive hygienic assessment of ambient air pollution in the area of food and processing industry enterprises’ location
Authors: Budarina Olga V. , Sabirova Zulfiya F. , Skovronskaya Svetlana A. , Dodina Natalia S. , Kokhan Aleksandra A. , Malysheva Alla G.
Published: April 2024

The purpose of the study is to assess atmospheric air pollution in a city where food and processing enterprises operate using a complex of instrumental, olfacto-odourimetric, calculated, and survey methods.
Materials and methods. Analytical studies of ambient air pollution were performed using the FOCUS GC-DSQ-II chromatography-mass spectrometer. Olfacto-odourimetric studies of the presence and intensity of odour in the area of the enterprises were carried out in accordance with the method of organoleptic control downwind at various distances from sources. The measurement of the odour level at the discharge of the coffee extract spray dryer was carried out by dynamic olfactometry on the ECOMA TO-8 olfactometer. The calculation of odour dispersion was implemented according to a program using a methodology for calculating concentrations of harmful substances in ambient air.
Results. It was established that at the time of the research, the source of a persistent specific odour reaching the residential area was a coffee production enterprise. Up to seventy eight volatile organic compounds in concentrations not exceeding hygienic standards have been identified in the ambient air in the area of the enterprise’s location. Field olfacto-odorimetric studies and the conducted dispersion calculation indicate an offensive odour to be capable of causing “annoyance” to the population (3 points or higher with a probability of ≥ 5% according to the results of field studies or ≥ 3.5 OU (odour units) according to the calculation results) spreads up to 4 km from the main source of emissions.
Limitations. The main limitation of the study is the peculiarities of the operating mode of different enterprises, which makes it difficult to fully assess the environmental situation in the area of their location at the time of the research.
Conclusion. The results of these studies indicate the use of various methodological approaches (field olfacto-odorimetric measurements, calculation of odour dispersion), along with conducting population surveys, to significantly expand the possibilities of instrumental analysis for an objective assessment of ambient air pollution by complex multicomponent mixtures of odorous substances.
Soil pollution of the city with machine-building production by heavy metals and arsenic and epidemiological risk to public health
Authors: Martsev Anton A. , Selivanov Oleg G. , Kurbatov Yurij N. , Trifonova Tatyana A.
Published: April 2024

Introduction. The paper presents the results of a study for the assessment of the epidemiological risk to public health and the level of soil contamination with heavy metals and arsenic in the city of Kovrov, a large industrial center of the Vladimir region.
Materials and methods. The objects of the study are the morbidity in the population of the Kovrovsky district of the Vladimir region and the soil cover of the city of Kovrov, whose industrial enterprises specialize in the production of machine-building products. Soil samples were taken in the area of industrial enterprises, highways, and residential areas. The soil cover was examined by X-ray fluorescence method to determine the content of heavy metals and arsenic.
Results. The conducted study on the assessment of probable risk allowed establishing in the Kovrov district, relative to background regional values, children to have a very high risk for 10 classes of diseases, adults have a very high risk for 6 classes of diseases. Contamination of the Carpet city soil with heavy metals and arsenic has been established. The priority pollutants of the Kovrov soil are zinc, lead and arsenic, which belong to the first hazard class. There was a significant variation in the content of heavy metals within both industrial and residential zones. Extremely dangerous chemical contamination of the soil with heavy metals has been detected. The assessment of the level of chemical soil pollution, as an indicator of adverse effects on public health, showed the residential part of the city, where most of the residents live, to be located in the zone of moderately dangerous or dangerous category of soil pollution.
Limitations. The limitations of the study are related to one-time sampling and a small number of reference sites, which limits the possibilities of a broader interpretation of the data obtained.
Conclusion. The unfavourable state of the soil cover in the residential area of Kovrov requires the manaagement and conducting constant ecological and hygienic monitoring of this territory. To reduce pollutants in particular, heavy metals, entering the soil of the city and, it is necessary to improve the system for cleaning gas-air emissions of machine-building enterprises of the city, as well as to ensure the effective arrangement of sanitary protection zones. To reduce the content of heavy metals in the soil, it is necessary to carry out measures to detoxify contaminated soils.
On the issue of resolving disputes about the compliance of the research object with regulatory requirements
Authors: Rahmanin Yurij A. , Rozental Oleg M.
Published: April 2024

Conclusions on the fulfillment or violation of regulatory requirements ensuring the hygienic safety of the research object of the supervised object are carried out by state sanitary and epidemiological supervision bodies based on the results of laboratory studies of controlled indicators. These are, in particular, conclusions on the safety of drinking water sources for the population. The composition and properties of this water, on the instructions of sanitary and epidemiological supervision bodies and water supply institutions, can be examined equally by accredited laboratories that comply with the accreditation criteria in carrying out their activities. At the same time, unfortunately, it is impossible to guarantee the same results of laboratory testing of controlled microbiological, chemical, and other indicators, due to their variability and measurement errors. As a result, the conclusions about the quality and safety of water obtained by the supervisory authority and the supplier (user), primarily in cases concerning the boundary values of hygiene standards, may differ. For constructive resolution of controversial situations arising in this case, this paper proposes a method of tolerance control, the result of which is a logical judgment on the compliance or non-compliance of controlled quantities with established standards. It is shown how this reduces the risk of erroneous recognition of non-compliance of the composition or properties of water with hygienic requirements and guarantees safe water supply to the population. Authors suggested equations of admission control to assess compliance with the requirements of sanitary, epidemiological, and hygienic safety of controlled facilities. A method convenient for practical use is proposed, and using a specific example of monitoring the water quality of wells in the Talitsky district of the Sverdlovsk region, it is shown how it is possible to establish the water safety of almost half of the initially rejected water sources. The use of tolerance control is recommended if it is necessary to increase the reliability of hygienic conclusions on the safety of a wide range of supervised facilities, for which convenient mathematical expressions are given.
Hygienic aspects of mortality of the population of an industrial city
Authors: Ovchinnikova Elena L. , Kolchin Andrey S. , Kriga Aleksander S. , Plotnikova Olga V. , Shirinskaya Natalia V.
Published: April 2024

Introduction. The target indicators of the Federal Project “Clean Air” include a reduction in emissions of chemical pollutants by at least 20%. However, the main socially significant goal remains to improve the medical and demographic situation by reducing environmental and hygienic health risks.
The purpose of the study was to preliminary assess the reserves for reducing mortality in the city of Omsk by identifying the most unfavourable territories in terms
of atmospheric air quality and identify priority chemicals, presumably causing negative trend in mortality.
Materials and methods. To assess the quality of atmospheric air in the city of Omsk, the results of social and hygienic monitoring, environmental monitoring
of Federal Service of Russia on Hydrometeorology and Monitoring of the Environment (RosGidromet) for the multi-year period over 2009–2022 were used.
An analysis of the mortality rate of the population of Omsk for 2017–2022 was carried out. The data were studied in the context of municipal districts of the city of Omsk and in dynamics. Statistical methods were used in the study: ANOVA, correlation analysis, assessment of relative mortality risks.
Results. The relative risk (RR) of mortality for persons living in the most polluted areas of the city is 23–25% higher than in conditionally clean areas. Strong positive associations have been established: between the levels of actual total mortality and the specific gravity of atmospheric air samples exceeding the maximum single limit concentrations (R = 0.86; p < 0.05); between perennial average annual carbon monoxide concentrations and standardized rates of total mortality
(R = 0.93; p<0.05) and male mortality rates from all natural causes (R = 0.89; p<0.05).
Limitations. The study is limited to the statistical research methods used.
Conclusion. The results of the study can become the basis for more efficient use of administrative resources in municipal districts of the city. As additional reserves for reducing mortality, the development of primary prevention measures at the outpatient level is important. It is necessary to optimize methodological approaches in the health control system of the population living in risk areas with developed industry.
Monitoring of Klebsiella pneumoniae as one of the criteria of microecological characterization of a water body
Authors: Kalyuzhin Alexander S. , Bayrakova Alexandra L. , Morozova Marina A. , Latyshevskaya Natalya I. , Ruzhentsova Tatyana A.
Published: April 2024

Introduction. Representatives of the family Enterobacteriaceae are ubiquitous in the environment, causing severe, including opportunistic diseases in immunocompromised individuals. The occurrence of antibiotic-sensitive bacteria of the Klebsiella genus within the recreational zone of a water body is potent of posing an epidemiologic danger to the inhabitants of the settlement.
Materials and Methods. Water samples from the surface aquifers of the Don and Temernik rivers of Rostov-on-Don served as the material for the study. The sensitivity of isolates of Kl. pneumoniae isolates to fourteen antibacterial preparations were investigated by disk-diffusion method in accordance with the requirements of MUK 4.2.1980-04 and EUCAST v. 13.0 (2023). 13.0 (2023). Carbapenemase genes VIM, IMP, NDM, KPC, OXA-48, NDM were determined using commercial diagnostic kits AmpliSense MDR MBL-FL, AmpliSense MDR KPC/OXA-48-FL, AmpliSense MDR Ab-OXA-FL.
Results. In 2022, 247 isolates of Klebsiella pneumoniae were isolated in 14 biotopes of water bodies of Rostov-on-Don. Biotopes of epidemiological significance were identified with the presence of antibiotic resistance genes in 28 isolates isolated above and below the sewage discharge site (sampling point #1 and #5) and strains isolated from the mouth of the Temernik River (sampling point #14). Phenotype of multidrug-resistant (MDR) in point No. 1 possessed 22%, point No. 5 – 26.9%, point No. 14 – 26%; phenotype of extreme drug resistance (XDR) in point No. 1 possessed 11.1 %, point No. 5 – 15.3%, point No. 14 – 13%; phenotype of pan-drug-resistant (PDR) in point No. 1 did not possess, point No. 5 – 3.8%, point No. 14 – 4.3%.
Limitations. A limitation of the study is related to the location of water sampling from the river. Don and R. Temernik on the territory of Rostov-on-Don, covering from March to November 2022. In this article, we limited ourselves to sanitary-bacteriological and molecular genetic analysis.
Conclusion. The detection of PDR, XDR, and MDR antibiotic-resistant phenotypes of Klebsiella pneumoniae, as well as the detection of resistance genes, indicates to an increased risk of water-associated acute intestinal infections, especially in immunosuppressed individuals.
Evaluation of the Epstein–Barr virus occurrence at the present stage (literature review)
Authors: Sizova Elena N. , Fedorovskaya Nadezhda S.
Published: April 2024

The purpose of this article is to review and analyze the foreign and domestic scientific papers to assess the Epstein-Barr virus (EBV) occurrence in the human population.
A search of Russian and foreign publications in the PubMed and E-library databases was conducted. The high ecological and medical significance
of EBV-infection is due to its global spread in the human population, lifelong persistence of EBV in the human body. Evidence has been collected EBV to be involved in the development of various somatic pathologies, such as rheumatic diseases and vasculitis, chronic kidney disease, cardiovascular pathologies, pathologies of the gastrointestinal tract, T- and B-cell lymphomas in children and adults, nasopharyngeal carcinoma. These diseases are the main causes of population disability and premature death not only in Russia, but also in the World. The deterioration of the ecological and epidemic situation for
EBV-infection is associated with the other infectants spread that change the population immunological status. These include the human immunodeficiency virus, hepatitis B and C viruses, SARS-CoV-2, Mycobacterium tuberculosis. With the simultaneous persistence of these infectants, their synergistic or antagonistic effect on the human body occurs. In the modern World, the COVID-19 and the EBV-infection are simultaneously developing. It is difficult to say which infection is more significant in terms of medical, social. and economic losses of the human population. The EBV has been undeservedly given little attention.
It is necessary to optimize preventive measures and epidemic surveillance for EBV-infection.
The Value of Emotional Intelligence: Self-Awareness, Self-Regulation, Motivation, and Empathy as Key Components
Authors: Antonopoulou Hera
Published: April 2024

This paper aims to review the concept of Emotional Intelligence systematically. In essence, Emotional Intelligence pertains to our capacity to identify, comprehend, and regulate our own emotions, as well as the emotions of others, thereby fostering the cultivation of positive interpersonal connections. This study will examine the dimensions of Emotional Intelligence outlined by researchers, exploring its definitions, associations with age and gender, assessment methods, and overall advantages. Consequently, a comprehensive and methodical review of the existing literature was conducted using prominent academic databases such as Science Direct, Google Scholar, ResearchGate, and APA PsycNet. In summary, Emotional Intelligence is not a singular, homogeneous concept but a combination of various interconnected components. Integrating self-awareness, self-regulation, motivation, and empathy enables individuals to navigate their social environment effectively, rendering emotional intelligence (EI) a precious asset in both personal and professional domains.
Dynamics of Industrialization: Leadership Transformation in Indigenous Papuans
Authors: Mokodompit Limi , Kasnawi M Tahir , Abdullah Suparman , Radjab Mansyur
Published: April 2024

This research explores the dynamics of industrialization and leadership transformation in indigenous Papuans, focusing on the Comoros Mimika Tribe in Papua Province, particularly in the context of the relationship with PT Freeport. This research uses a qualitative approach to explore it. Data collection was conducted through in-depth interviews with various stakeholders, such as indigenous leaders, youth, women, NGOs, and the government in the Comoros Mimika Tribe. In addition, participatory observations and document analysis were also conducted to gain a holistic understanding of the dynamics of leadership and social change in the community. The results show that diverse perspectives are presented through the views of indigenous leaders, youth, women, NGOs, and governments on this change. Indigenous leaders stressed the need to preserve traditional values while accommodating the realities of modernization, while youth saw change as an opportunity to improve social and economic conditions. Women fight for gender inclusion and protection of their traditional roles, NGOs and governments seek to unite economic development with the preservation of indigenous peoples' cultures and interests. These findings reflect the complexity of the relationship between tradition and modernity and highlight the challenges and opportunities in maintaining a balance between the two in the context of PT Freeport in indigenous Papuans.
As vacinas para COVID-19 e suas tecnologias: potencial e perspectivas
Authors: Abreu Nunes Viviane , Santiago Chambergo Felipe , Apetito Akamatsu Milena , Lee Ho Paulo
Published: April 2024

Até dezembro de 2020, havia mais de 200 vacinas candidatas para COVID-19 sendo desenvolvidas. Entre estas, pelo menos 52 já estão em fase de testes em humanos, enquanto outras, atualmente em fase I/II, devem entrar na fase III nos próximos meses.

Normalmente, muitas vacinas são avaliadas antes que qualquer uma seja considerada segura e eficaz. Assim, de todas as vacinas que são estudadas in vitro e em animais de laboratório, cerca de sete em cada 100 serão consideradas adequadas para início dos testes clínicos em humanos. Das vacinas que chegam aos ensaios clínicos, apenas uma em cinco é bem-sucedida. Ter muitas vacinas diferentes em desenvolvimento aumenta as chances de que haja uma ou mais bem-sucedidas e que se mostrem seguras e eficazes para as populações pretendidas.

Existem diferentes abordagens para se projetar uma vacina. Suas diferenças residem no fato de usarem um vírus (ou bactéria) inteiro(a) ou apenas as partes do organismo que ativam o sistema imunológico (proteína ou açúcar), ou o material genético que fornece as instruções para a produção de proteínas específicas, capazes de estimular a resposta imune. Atualmente, outra modalidade tem sido proposta: uma vacina baseada no uso de células apresentadoras de antígeno, por exemplo. Nesse artigo, iremos apresentar e discutir as principais plataformas de produção de vacinas contra a COVID-19, em especial, das vacinas que estão aprovadas para uso comercial.
Development of Diffuse Large B-Cell Lymphoma and Sarcoidosis In The Course Of Multiple Myeloma: A Case Report with Literature Review
Authors:   Hematology Section of First Department of Propaedeutic Internal Medicine, National and  Kapodistrian University of Athens’ Medical School. Laikon Hospital, Athens, Greece, Gkioka Annita-Ioanna , Koudouna Aspasia ,   Hematology Section of First Department of Propaedeutic Internal Medicine, National and  Kapodistrian University of Athens’ Medical School. Laikon Hospital, Athens, Greece, Bartzis Vassiliki ,   Hematology Section of First Department of Propaedeutic Internal Medicine, National and  Kapodistrian University of Athens’ Medical School. Laikon Hospital, Athens, Greece, Papaioannou Paraskevi ,   Hematology Section of First Department of Propaedeutic Internal Medicine, National and  Kapodistrian University of Athens’ Medical School. Laikon Hospital, Athens, Greece, Papadatou Mavra ,   Hematology Section of First Department of Propaedeutic Internal Medicine, National and  Kapodistrian University of Athens’ Medical School. Laikon Hospital, Athens, Greece, Alexandropoulos Alexandros ,   Hematology Section of First Department of Propaedeutic Internal Medicine, National and  Kapodistrian University of Athens’ Medical School. Laikon Hospital, Athens, Greece, Gkiokas Alexandros ,   Hematology Section of First Department of Propaedeutic Internal Medicine, National and  Kapodistrian University of Athens’ Medical School. Laikon Hospital, Athens, Greece, Bitsani Aikaterini ,   Hematology Section of First Department of Propaedeutic Internal Medicine, National and  Kapodistrian University of Athens’ Medical School. Laikon Hospital, Athens, Greece, Mylona Maria ,   Hematology Section of First Department of Propaedeutic Internal Medicine, National and  Kapodistrian University of Athens’ Medical School. Laikon Hospital, Athens, Greece, Kyrtsonis Marie-Christine ,   Hematology Section of First Department of Propaedeutic Internal Medicine, National and  Kapodistrian University of Athens’ Medical School. Laikon Hospital, Athens, Greece
Published: April 2024

Despite significant survival increment due to treatment improvement, multiple myeloma (MM) remains an incurable disease. We herein describe a unique patient that is not only a MM long survivor despite adverse features, such as the occurrence of extramedullary disease at relapse, but also developed, sixteen years after MM diagnosis, an extranodal diffuse large B-cell lymphoma (DLBCL) of the small intestine. The patient eventually achieved cure but developed sarcoidosis two years later that regressed with corticosteroids. Today, after 26 years of follow-up the patient is in remission and in good clinical condition.
Antihypertensive Medications Can Prevent Fostamatinib-Induced Blood Pressure Elevation
Authors:   Apollo College of Pharmacy, Anjora Durg 491001 C.G, India, Sonwani Hari Prasad
Published: April 2024

Fostamatinib is a tyrosine kinase inhibitor that has been shown in clinical trials to be effective against spleen tyrosine kinase in patients suffering from rheumatoid arthritis. Fostamatinib medication was linked in clinical trials to a slight increase in systemic arterial Blood Pressure (BP). This observation is consistent with other kinase inhibitors, particularly those that obstruct VEGFR2 signaling. In conscious rats, we examined the relationship between the elevation of blood pressure caused by fostamatinib and the plasma levels of the fostamatinib-active metabolite R940406. We discovered that there was a strong correlation between changes in R940406 plasma concentration and the time course of the blood pressure effect, suggesting a direct pharmacological relationship. The experiments yielded free plasma levels of R940406 up to 346 nmol/L, which is greater than the mean peak free plasma concentration of 49 nmol/L that has been recorded in clinical settings. We beyond the clinically noted mean peak free plasma concentration of 49 nmol/L, up to 346 nmol/L. We’ve shown that there are several effective ways to reduce the blood pressure elevation caused by fostamatinib dosing, including simple drug withdrawal or condoning with a variety of common antihypertensive medications like atenolol, captopril, and nifedipine. These results provide credence to prospective strategies for preserving patient safety during fostamatinib therapy. Additionally, we have shown—using nifedipine as an example drug—that this blood pressure control was not brought about by a decrease in R940406’s plasma exposure, indicating that potential pharmacological benefits of the investigational drug may be preserved while blood pressure control is managed with the use of conventional medications.
Impact of Regulatory Influence on Financial Performance of National Microfinance Banks in Nigeria
Authors: Aliyu Abdulaziz , Gambo Nasamu , Enesi Ozigi Emmanuel , Nwoye May Ifeoma , Ibrahim Musa
Published: April 2024

While existing literature has acknowledged the pivotal role of regulatory measures in shaping the operational landscape of financial institutions, there remains a notable gap in understanding the direct consequences of such regulations on the financial performance of NMBs in Nigeria. This study explores the impact of regulatory measures, specifically sanctions, penalties, and Minimum Capital Requirement (MCR), imposed by the Central Bank of Nigeria (CBN) on the financial performance of NMBs. This research adopts an ex-post facto research design, using data from the past six years of seven operational NMBs. The Agency Theory and Pecking Order Theory provide theoretical frameworks to interpret these relationships. The study reveals that regulatory measures significantly influence the allocation of micro loans within NMBs, reflecting the alignment of managers’ interests with those of stakeholders. However, regulatory factors alone do not adequately explain variations in ROA, indicating the presence of complex and unexamined factors affecting financial performance. Individual regulatory variables, such as sanctions, penalties, and MCR, also do not have a significant multivariate impact on RMLT or ROA. The study recommends that Nigerian National Microfinance Banks (NMBs) should closely monitor and adapt to Central Bank regulations, particularly regarding sanctions, penalties, and Minimum Capital Requirement, despite the absence of a direct multivariate link to financial performance indicators; it also advises diversifying strategies to enhance Returns on Assets (ROA) and suggests further research for a deeper understanding of NMB sustainability dynamics.