bluuebunny/crossref_metadata_2025 huggingface dataset:
Expression of cytokines in gingival crevicular fluid associated with tooth movement induced by aligners: a pilot study
Authors: Chami Vitória de Oliveira , Nunes Livia , Capelli Júnior Jonas
Published: November 2018

ABSTRACT Introduction: The search for more aesthetic and comfortable orthodontic devices has led to an increase in the use of clear aligners. Objective: To increase knowledge on biological mechanisms of orthodontic tooth movement using Invisalign aligners. Methods: This study included 11 patients with a mean age of 23.6 ± 4.8 years. Cases planning included alignment and leveling of lower incisors using Invisalign aligners. Gingival crevicular fluid samples were collected from the lower incisors on the day of delivery of aligner number 1 (T0) and after 1 (T24h), 7 (T7d), and 21 (T21d) days. During the observation period of the study, the patients used only the aligner number 1. Levels of nine cytokines were quantified using Luminex’s multi-analysis technology. Non-parametric tests were used for comparisons between cytokine expression levels over time. Results: Cytokine expression levels remained constant after 21 days of orthodontic activation, except those of MIP-1β, which presented a statistical difference between T24h and T21d with a decrease in the concentration levels. IL-8, GM-CSF, IL-1β, MIP-1β, and TNF-α showed the highest concentrations over time. Conclusions: The different behavior in the levels of the investigated cytokines indicates a role of these biomarkers in the tissue remodeling induced by Invisalign.
Evaluation of the attractiveness of different gingival zeniths in smile esthetics
Authors: Nomura Suzy , Freitas Karina Maria Salvatore , Silva Paula Patrícia Cotrin da , Valarelli Fabricio Pinelli , Cançado Rodrigo Hermont , Freitas Marcos Roberto de , Oliveira Renata Cristina Gobbi de , Oliveira Ricardo Cesar Gobbi de
Published: November 2018

ABSTRACT Objective: To evaluate the smile attractiveness of different gingival zeniths by general dentists, orthodontists and laypersons and the esthetic perception in the symmetric and asymmetric changes in gingival zeniths. Methods: Posed photographs of five patients were taken and digitally manipulated in Keynote software, in the gingival zenith region, in increments of 0.5 to 1mm in maxillary central and lateral incisors, symmetrically and asymmetrically, in nine different ways for each patient. The photos were then uploaded to a website, where evaluators (general dentists, orthodontists and laypersons) could observe and vote according to their esthetic perception, scoring from 1 to 10, 1 being the least attractive and 10 the more attractive. Kruskal-Wallis and Mann-Whitney tests were used for comparison. Results: Asymmetric gingival zeniths were less attractive than symmetrical gingival zeniths; gingival zenith differences greater than 1mm were perceptible in the smile attractiveness, both by laypersons, general dentists and orthodontists. When comparing maxillary central incisors with maxillary lateral incisors, the aesthetic change performed in the central incisors are more perceptible than those performed in lateral incisors, both symmetrical and asymmetrical. In a general way, orthodontists and general dentists are more critical in the evaluation and perception of gingival zenith changes, with the laypersons perceiving this change only from 1mm of maxillary right central incisor asymmetrical change. Conclusions: Asymmetric gingival zeniths are less attractive than symmetrical ones. Gingival zenith differences greater than 1mm are perceptible in the smile attractiveness. Orthodontists and general dentists are more critical in evaluating smile esthetics.
Effect of mangosteen peel extract as an antioxidant agent on the shear bond strength of orthodontic brackets bonded to bleached teeth
Authors: Alhasyimi Ananto Ali , Pudyani Pinandi Sri , Hafizi Ikmal
Published: November 2018

Abstract Introduction: The number of patients who seek orthodontic treatment that may have a history of tooth bleaching is increasing over the time. Bleaching may influence the decrease of the bond strength of orthodontic brackets. Objective: To determine and prove the effect of mangosteen peel (MP) extract to reverse the reduced shear bond strength (SBS) of orthodontic brackets after bleaching. Methods: A total of 150 maxillary first premolar teeth were randomly divided into 6 experimental groups as follow (n=25): negative-control (N: no bleaching), positive-control (P: bleaching + no treatment), and the treatment groups (bleaching + 10% sodium ascorbate (SA), 10% (MP-10), 20% (MP-20) and 40% (MP-40) MP extract gel). After treatment, the brackets were bonded with the resin-modified glass ionomer cement, SBS testing was performed using universal testing machine, and the adhesive remnant index (ARI) was examined using stereoscopic microscope after debonding. The SBS data were analyzed by analysis of variance (Anova) and the Tukey test. For the ARI, the Kruskal-Wallis test was performed. Result: There was significant SBS difference (p< 0.001) between various groups. The group without bleaching showed significantly higher SBS (8.19 ± 2.26 MPa) compared to others, while SBS in the group treated with 40% MP gel was significantly higher (7.93 ± 1.92 MPa) than other groups treated with antioxidants. The failure of orthodontic brackets bonded after bleaching and treatment using MP extract occurred at the enamel-adhesive interface. Conclusion: The application of MP extract as an antioxidant after bleaching was effective in reversing the reduced shear bond strength of orthodontic brackets after bleaching.
Perception of attractiveness of missing maxillary lateral incisors replaced by canines
Authors: Souza Ricardo Alves de , Alves Girlaine Nunes , Mattos Juliana Macêdo de , Coqueiro Raildo da Silva , Pithon Matheus Melo , Paiva João Batista de
Published: November 2018

ABSTRACT Objective: The aim of this study was to evaluate the degree of perception of attractiveness of the smile among dentists, dental students, and lay persons in cases of agenesis of the maxillary lateral incisors replaced by canines for space closure. Methods: A smiling front view extraoral photograph of a 20-year-old woman was digitally altered simulating agenesis and its treatment, by means of: repositioning, reshaping or bleaching the canine, and gingival contour. A questionnaire was distributed to individuals of the three groups (n= 150), with a view to evaluating their degree of esthetic perception. An attractiveness scale was also used, with ‘0’ representing unattractive and ‘10’, very attractive. Results: In the comparative evaluation among all the photographs, the original image obtained the highest level of acceptance. Photograph ‘i’ (agenesis of both lateral incisors treated with reposition and reshaping of the canines) was ranked as the least attractive by the dentists, whereas the student and lay persons ranked photograph ‘f’ (agenesis of both lateral incisors treated with reposition of the canines, gingival contour, bleaching and reshaping) as the worst. Conclusion: The methods of treatment most accepted among the dentists and students were those that involved changes in the gingival contour, whereas among lay persons, they were those that involved only reshaping.
Mini-implant selection protocol applied to MARPE
Authors: Nojima Lincoln Issamu , Nojima Matilde da Cunha Gonçalves , Cunha Amanda Carneiro da , Guss Natan Oliveira , Sant’Anna Eduardo Franzotti
Published: November 2018

Abstract Introduction: Rapid maxillary expansion (RME) is the therapy of choice to correct skeletal transverse dimension in children and adolescents, associating orthopedic and dental effects. In an attempt to prevent the undesirable dentoalveolar effects and optimize the potential of skeletal expansion in individuals in advanced stages of skeletal maturation, the miniscrew-assisted rapid palatal expander (MARPE) was proposed by Lee et al. in 2010. Objective: This paper presents a systematized protocol for selection of miniscrews indicated for MARPE, by the evaluation of cone-beam computed tomographies (CBCT). Variables related with the bone and soft tissue thicknesses at the palatal regions of interest, as well as in relation to the fixation rings of miniscrews of the palatal expander are analyzed and discussed to provide better performance in the clinical practice.
Efeito da idade no processamento auditivo temporal: benefício da modulação do mascaramento e efeito do pós-mascaramento
Authors: Advíncula Karina Paes , Menezes Denise Costa , Pacífico Fernando Augusto , Costa Maria Lúcia Gurgel da , Griz Silvana Maria Sobral
Published: November 2018

RESUMO Objetivo Investigar o efeito da idade no benefício da modulação do ruído mascarante (masking release) e no pós-mascaramento ( forward masking). Métodos Participaram da pesquisa jovens (média de idade de 18 anos e quatro meses) e idosos (média de idade de 64 anos e três meses) falantes nativos do Português Brasileiro e com audição normal. Mediante uso de sentenças da versão brasileira do Hearing in Noise Test, determinou-se, para ambos os grupos, limiares de reconhecimento em presença de ruído estável e em presença de ruído modulado em amplitude (10 Hz). Para a pesquisa do pós-macaramento, foram determinados limiares auditivos em intervalos de tempo de 4, 16, 64 e 128 milissegundos, após a interrupção do ruído. Para avaliar a normalidade dos resultados obtidos, foi aplicado o teste de Shapiro-Wilk. Nas variáveis em que a normalidade foi indicada, aplicou-se o teste t de Student para amostras independentes e nos casos em que a normalidade não foi encontrada, aplicou-se o teste de Mann-Whitney. Foi considerado o nível de significância de 5% Resultados Observou-se o benefício da modulação do mascaramento nos dois grupos. Porém, esse benefício foi menor para o grupo dos idosos (p-valor < 0,001). Na investigação do pós-mascaramento, houve diferença significativa entre os grupos, na média de limiares em 128 milissegundos, após a cessação do ruído (p-valor = 0,006). Conclusão O estudo mostra efeito da idade no benefício de modulação do ruído mascarante e no pós-mascaramento.
Regionalization of precipitation with determination of homogeneous regions via fuzzy c-means
Authors: Gomes Evanice Pinheiro , Blanco Claudio José Cavalcante , Pessoa Francisco Carlos Lira
Published: November 2018

ABSTRACT Knowledge about precipitation is indispensable for hydrological and climatic studies because precipitation subsidizes projects related to water supply, sanitation, drainage, flood and erosion control, reservoirs, agricultural production, hydroelectric facilities, and waterway transportation and other projects. In this context, methodologies are used to estimate precipitation in unmonitored locations. Thus, the objectives of this work are to i) identify homogeneous regions of precipitation in the Tocantins-Araguaia Hydrographic Region (TAHR) via the fuzzy c-means method, ii) regionalize and estimate the probability of occurrence of monthly and annual average precipitation using probability distribution models, and iii) regionalize and estimate the precipitation height using multiple regression models. Three homogeneous regions of precipitation were identified, and the results of the performance indices from the regional models of probability distribution were satisfactory for estimating average monthly and annual precipitation. The results of the regional multiple regression models showed that the annual mean precipitation was satisfactorily estimated. For the average monthly precipitation, the estimates of multiple regression models were only satisfactory when the months used were distributed in the dry and rainy seasons. Therefore, our results show that the methodology developed can be used to estimate precipitation in unmonitored locations in the TAHR.
Association of Modified-FOLFIRINOX-Regimen-Based Neoadjuvant Therapy with Outcomes of Locally Advanced Pancreatic Cancer in Chinese Population
Authors: Li Xiang , Guo Chengxiang , Li Qinghai , Wei Shumei , Zhang Qi , Chen Yiwen , Shen Yinan , Ma Tao , Li Guogang , Gao Shunliang , Que Risheng , Lou Jianying , Yu Risheng , Yuan Ying , Wei Qichun , Huang Pintong , Liang Tingbo , Bai Xueli
Published: November 2018

Lessons Learned

Modification of FOLFIRINOX significantly improves safety and tolerability in Chinese patients with locally advanced pancreatic cancer. Patients with locally advanced pancreatic cancer benefit from neoadjuvant therapy and experience a much better survival than patients with upfront surgery.

Background

The objective of this study was to evaluate the efficacy of modified-FOLFIRINOX (mFOLFIRINOX) regimens in Chinese patients with locally advanced pancreatic cancer (LAPC) and to compare outcomes between patients with LAPC treated with mFOLFIRINOX-based neoadjuvant therapy (LAPC-N) and patients with LAPC who underwent upfront surgery (LAPC-S).

Methods

Forty-one patients with LAPC-N were enrolled prospectively. Imaging features, chemotherapy response, adverse events, perioperative complications, histology, and survival were analyzed. Seventy-four patients with resectable pancreatic cancer (RPC) (from April 2012 to November 2017) and 19 patients with LAPC-S (from April 2012 to March 2014) were set as observational cohorts, and data were collected retrospectively. LAPC-N patients with adequate response underwent surgical treatment, whereas continuous chemotherapy was given to LAPC-N patients who were not deemed resectable after treatment, and the response was re-evaluated every 2 months.

Results

Forty-one patients with LAPC received mFOLFIRINOX with a response rate of 37.1%. The most common severe adverse events were neutropenia and anemia. mFOLFIRINOX-based neoadjuvant therapy contributed to a remarkable decrease in CA19-9 level and tumor diameter. Fourteen LAPC-N patients underwent surgery (LAPC-N-S) after downstaging. Compared with LAPC-N-S cases, LAPC-S patients had longer operative time, more blood loss, and a higher risk of grade 5 complications. The median overall survival (OS) and progression-free survival (PFS) of LAPC-N-S patients were 27.7 months and 19.3 months, respectively, which were similar to those of patients with RPC (30.0 months and 23.0 months) and much longer than those of patients with LAPC-S (8.9 months and 7.6 months), respectively.

Conclusion

Neoadjuvant chemotherapy such as the mFOLFIRINOX regimen can be recommended for Chinese patients with LAPC after dose modification. Patients with LAPC-N who underwent surgery obtained significantly improved survival compared with patients in the observational LAPC-S cohort, who did not undergo neoadjuvant therapy.
Assessing recycling attitude and behaviour in Ras Al Khaimah, UAE
Authors: Assaf Hamed , Idwan Sahar , Farhat Maissa
Published: November 2018

Ras Al Khaimah (Rak) is the northernmost emirate of the United Arab Emirates (UAE). The emirate has witnessed a phenomenal economic and demographic growth. Taking a progressive stance on sustainability, the emirate has undertaken a sustainability strategy that aims at increasing its recycling rate from the current level of about 15 to 75% by 2021. The current study examines the socio-demographic (gender, age, family size, education and household income) and environmental awareness determinants of recycling attitude and behaviour in Rak. This is done through statistical analysis of results from a public survey, where 227 respondents were interviewed face to face to respond to several questions designed to get insight into the main drivers and factors influencing recycling in Rak. The results indicate that environmental awareness and education level are significantly associated with recycling behaviour in Rak at a significance level of 0·001. Environmental awareness is also associated with recycling attitude, but at a lesser significance level of 0·07. Other socio-economic and demographic factors such as gender, age, family size and income are not significantly associated with recycling attitude and behaviour. The results from the study provide valuable insight that would help policymakers design effective recycling campaign.
Optimisation of conditions of phosphorus release from pharmaceutical waste sludge
Authors: Zeng Ping , Li Juan , Cheng Jianguang , Song Yonghui , Wei Jian
Published: November 2018

With the short supply of phosphorus (P) resources all over the world, more and more phosphorus-rich excess sludge is produced. In this study, a pharmaceutical surplus activated sludge was subjected to alkali and ultrasonic treatment to promote the release of phosphorus. The optimisation of phosphorus release from pharmaceutical surplus activated sludge by alkali and ultrasonic treatment was investigated. The response surface methodology was adopted to optimise the conditions for phosphorus and organic matter release. A quadratic model was established to describe phosphorus and organic matter release. The variance was analysed by using the Design-Expert software, and the optimum operation conditions were decided on. The results indicated that the quadratic model could well fit the relationship between the release of phosphate phosphorus (PO4 3−-P) and chemical oxygen demand (COD) and the influencing factors. The order of influence on the release of phosphate phosphorus and COD was as follows: pH > total solids > ultrasonic power > time. The maximum release of phosphate phosphorus was 15·3%.
Torasik Çıkış Sendromlu İki Pediatrik Vaka
Authors: ÇOKYAMAN Turgay , DAMAR Çağrı
Published: November 2018

Torasik
çıkış sendromu (TÇS) brakiyal pleksus, subklaviyan arter ve/veya ven gibi
nörovaskuler yapıların klavikula ve skalen kaslar arasında sıkışması sonucu
ortaya çıkan bir hastalıktır. Çocukluk çağında çok sık görülen bir hastalık
olmadığı için bu yaş grubunda tanısı kolaylıkla gözden kaçabilmektedir. Bu
makalede geç pubertal döneme kadar tanı konulamamış iki TÇS vakası sunulmuştur.
Her iki vakada boyun ve omuz ağrısı, kol ve ön kolda ağrı ve güç kaybı gibi
benzer nöropatik şikayetler ile baş vurmuşlardır. Üst ekstremitelerde derin
tendon refleksleri (DTR) canlı, kas gücü 5/5, kas atrofisi veya kontraktür ve
patolojik refleks saptanmadı. Duyu muayenesinde üst ekstremitelerde C7-C8-T1
dermatomunda hiperaljezi gözlemlendi. X-ray/bilgisayarlı tomografide (BT)
servikal kosta varlığı ve dopler ultrasonografide (USG) üst ekstremite
abduksiyon ve dış rotasyonu ile axiller arter kan akımı azalması gösterilerek
tanı kesinleştirildi. Servikal kosta, anomalous fibröz kosta varlığı ve skalen
üçgenin konjenital darlığı TÇS’una neden olabilecek en önemli predispozan
faktörlerdir. Hastalar genellikle üst ekstremitelerde ağrı, parasteziler ve ön
kol ve kolda güçsüzlük gibi nöropatik şikayetler ile başvurmaktadırlar. Pozitif
Tinel bulgusu, Elvey’in üst ekstremite gerim testi, Adson testi, Allen testi ve
yükseltilmiş kola germe testi (EAST) gibi provakatif testler ile semptomlar
tetiklenebilmektedir. X-ray, BT, dopler USG ve elektromiyografi (EMG) tanıya
ulaşmakta kullanılan tetkiklerdir. Davranış değişiklikleri, iş alanlarında
ergonomik düzenlemeler, uygun postür eğitimleri ve gevşeme egzersizleri
(abdominal solunum, yumuşak masaj, sinir kaydırma egzersizleri ve boyun ve omuz
germe egzersizleri gibi) önemli konservatif tedavi yöntemleridir. En az 3 ay
uygulanan konservatif tedaviye rağmen semptomları gerilemeyen hastalara cerrahi
tedavi yapılmaktadır.
Kolon Kanserlerinde Bilgisayarlı Tomografinin Lenf Nodu Tespitindeki Rolü
Authors: SARI Ramazan , DURAK Doğukan , YAZICIOĞLU Mustafa Ömer , GÜRER Ahmet
Published: November 2018

Amaç:
Bilgisayarlı Tomografi malign hastalıkların tanı ve tedavisinde yaygın olarak
kullanılan görüntüleme yöntemidir. Kolon kanserinde metastatik lenf nodu sayısı
prognozu belirlemede önemli kriterlerdendir. Biz bu çalışmada kolon kanseri
saptanan hastalarda; tomografik bulgularla, patoloji raporlarını karşılaştırmayı
amaçladık.

Gereç ve Yöntemler:
Çalışmamızda; Nisan 2015 ile Nisan 2016 tarihleri arasında kolon kanseri tanısı
ile Ankara Atatürk Eğitim ve Araştırma Hastanesinde opere edilen hastaların
dosya bilgileri incelendi. Kolon kanseri nedeniyle genel cerrahi kliniğinde
ameliyat edilen hastalardan, ameliyat öncesi tüm abdominal bilgisayarlı
tomografi incelemesi yapılan toplam 72 hasta çalışmaya dahil edildi. Hastaların
tomografi ve patoloji raporları retrospektif olarak incelendi. Bilgisayarlı
tomografide görüntülenen lenf nodları (btN) 
patolojik lenf nodu (pN) durumu ile karşılaştırıldı. Tomografinin
patolojik lenf nodunu saptayabilme oranı araştırıldı.

Bulgular: Çalışmaya
alınan 72 hastanın 36’sında btN+ saptandı. Patolojik olarak ise toplam 44
hastada pN+ olduğu
görüldü.
btN+ 36 hastanın 28’inde pN+ olduğu gözlendi. btN- 36 hastanın ise
16’sında pN+ olduğu saptandı. Bilgisayarlı tomografinin lenf nodu
tespitindeki; Duyarlılığı: %64, Özgüllüğü: %71, Pozitif Prediktif Değeri: %77, Negatif
Prediktif Değeri: %55 olarak hesaplandı. Ayrıca pN2 grubunda bilgisayarlı
tomografide lenf nodu saptanma oranının pN1 grubuna göre daha yüksek olduğu saptandı.
(p<0.05)

Sonuç: Kolon kanserinin her aşamasında kullanılan
bilgisayarlı tomografinin bölgesel patolojik lenf nodu tespitinde de kullanılabileceği
görüldü. Benzer çalışmalar sayesinde kolon kanserlerinde yeni tedavi
modaliteleri geliştirilebileceği kanaatindeyiz.
Realising the Benefits of Integrated Data for Local Policymaking: Rhetoric versus Reality
Authors: Durrant Hannah , Barnett Julie , Rempel Emily Suzanne
Published: November 2018

This article presents findings from local government projects to realise the benefits of big data for policy. Through participatory action research with two local statutory authorities in the South West of England, we observed the activities of identifying, integrating and analysing multiple and diverse forms of data, including large administrative datasets, to generate insights on live policy priorities and inform decision-making. We reveal the significance of both data production and policymaking contexts in explaining how big data of this kind can be called upon and enacted in policy processes.
Big Data Applications in Governance and Policy
Authors: Giest Sarah , Ng Reuben
Published: November 2018

The editorial sets the scene for this thematic issue on big data applications in governance and policy. It highlights the lack of engagement in the current literature with the application of big data at the cross-section of governance of data and its utilization in the policy process and draws out aspects related to its definition and future research agenda. The contributions highlight several aspects related to big data in different contexts, such as local and national government as well as a variety of policy areas. They converge on the idea that big data applications cannot overcome existing political and structural limitations that exist in government. This leads to a future research agenda that looks at the disconnect between data production and usage as well as identifying policy issues that are more or less suitable for data analytics.
Pancreatic type dysfunction of oddi sphincter in children
Authors: Privorotsky Valery F , Luppova Natal’ya E
Published: November 2018

Anatomical and functional characteristics of the pancreas and its close relationship to adjacent organs, primarily duodenum and biliary tract, cause its frequent involvement in pathological process. Difficulties in differentiation of functional and organic pathology of the pancreas are associated not only with the difficulties of diagnostic of functional diseases, but also with the problems of classification and definitions. As to realities of today optimal version is one proposed by the authors of ICD 10 and found further development in the materials of the Rome III consensus - namely the Oddi sphincter dysfunction in pancreatic type. Under this diagnosis there is the possibility for logical explanation of involvement of pancreas in pathological process. The article also describes the diagnostic criteria for the Oddi sphincter dysfunction in pancreatic type, which includes clinical, laboratory and instrumental signs. It is noted that the recommended set of instrumental examination in modern pediatric practice is not only unimplementable, but just is not necessary. The usefulness of the recommended methods (including procedures that are potentially dangerous in terms of developing pancreatitis) for functional disorders is discussing. In the article the issues of nutrition of children with diseases of the pancreas, as well as the program of medical correction of dysfunction of the sphincter of Oddi in pancreatic type, are described.
Case of heart disease in mixed streptococcal and Epstein - Barr virus infection
Authors: Levina Anastasiya S , Babachenko Irina V , Chuprova Svetlana N , Kochevaya Natalia V , Sharipova Elena V , Ibragimova Olesya M
Published: November 2018

Cardiac involvement in acute and chronic infectious diseases - an actual pediatric problem. Diagnosis of myocarditis in children for general practitioners is difficult due to the lack of pathognomonic, specific only to this disease complaints, clinical and laboratory features. Symptoms of infection and myocarditis (fever, severe weakness, fatigue, shortness of breath, palpitations, headache, systolic murmur at the apex of the heart) are often the same. Many cases of myocarditis in viral and bacterial diseases remain undiagnosed, resulting in the outcome of a chronic cardiac disease. In order to increase alertness of doctors in relation to cardiac pathology at infectious diseases we have described a clinical example of heart disease when mixed streptococcal and Epstein - Barr virus infection in a 11-year-old girl. The peculiarity of this case is that the main symptom, indicating inflammation of the myocardium, was the ECG negative dynamics - the emergence of AV block of 1 degree in sinus tachycardia, whereas the level of cardiac enzymes (CK-MB, LDH) remained normal. Communication with the previous infection, the presence of one large (the appearance of pathological changes on ECG as AV block 1st degree) and two small (laboratory confirmation of infection - Epstein - Barr virus and streptococcus, tachycardia) diagnostic criteria of myocarditis, lack of valve heart disease and other major diagnostic criteria of acute rheumatic fever has allowed diagnosis of acute infection (viral and bacterial) myocarditis, focal (with a primary lesion of the conduction system of the heart). Thus, the only comprehensive assessment of complaints, clinical, laboratory and instrumental data allows to establish the diagnosis of carditis in infectious disease.
Features of asthenic syndrome in children with ascariasis
Authors: Ershova Irina B , Lokhmatova Irina A
Published: November 2018

Intestinal helminthic infections have various adverse effects on the health of children. Ascariasis is one of the most common intestinal helminthics. Long parasitism of the roundworm in the body of the child leads to the formation astheno-vegetative syndrome, lag in physical, mental and intellectual development.The aim of our study was to investigate the featuers of manifestations of asthenic syndrome in children of different age groups with intestinal stage of ascariasis. The results of 133 children observations (age from 1 to 18 years) with intestinal stage of ascariasis were presented in our research. Rate the overall status of children with identifying syndromes related to manifestations of worm infestations, particular attention was paid to the terms of clinical symptoms appearance of he disease. The study showed that the asthenic syndrome occurs in 3 times more often in children with intestinal stage of ascariasis, compared to the relatively healthy children (p < 0.01). The most characteristic symptoms of asthenic syndrome were slackness and fatigue (62.4%), irritability (64.66%), capriciousness and hysterical states (61.65%), decreased memory and attention (43.61%), emotional lability (34%) and headache (25.56%). In preschool children more frequently (p < 0.01) were recorded capriciousness and hysterical state (over 75%). Complaints about the deterioration of memory and attention deficits (55.56–76.47%) were observed in school-age children more frequently (p < 0.01). Young people significantly more common complainted on headaches (62.5%; p < 0.05). Slackness, fatigue and irritability occurred significantly more frequently (p < 0.01) among all age groups of children with ascariasis.
Functional dyspepsia through chronic gastritis in patients with marfan syndrome and marfan-like states
Authors: Rudoy Andrey S , Uryvaev Alexey M
Published: November 2018

The article presents the results of clinical and endoscopic examination of patients (n = 89; 33 ± 9,3 years; F : M/23 : 66) with confirmed chronic gastritis associated with hereditary disorders of connective tissue (Marfan syndrome phenotype and Marfan-like states) in order to examine the relationship associated HDCT as monogenic diseases - Marfan syndrome, as well as related pathology in the form of Marfan-like states with the clinical manifestations of functional dyspepsia and endoscopic picture of H. pylori infection in chronic gastritis. Diagnosis of Marfan syndrome was based on the revised criteria of Ghent. For the differential diagnosis with other “related” diseases of the connective tissue used syndrome diagnostic criteria of hypermobility of joints, Ehlers - Danlos syndrome. Evaluation of complaints and diagnosis of functional dyspepsia was based on the criteria of Rome III (2006) and the Florence Agreement. Evaluation of the symptoms of functional dyspepsia showed different from control (p < 0,05) lower frequency of epigastric pain syndromes and postprandial distress syndrome in a group with Marfan syndrome not associated with H. pylori infection and, at the same time, does not correlate with available in this group of patients a high frequency of precancerous lesions in the gastric mucosa. Frequent endoscopic manifestations associated with the HDCT served esophagitis gastroduodenal motility disorders and the development of GERD with catarrhal esophagitis (p < 0,05) and the absence of erosive and ulcerative lesions of gastroduodenal mucosa (p < 0,05). The findings strongly indicate the absolute necessity of endoscopic and morphological screening regardless of the presence of gastrointestinal complaints in patients with associated HDCT.
Microchimerism in children with perinatal pathology
Authors: Treskina Natalia A , Polyakova Anastasia P , Volkova Olga Ya , Vasiliev Vladimir E , Petrenko Yuriy V , Ivanov Dmitriy O
Published: November 2018

The article presents the opportunity to identify the phenomenon of microchimerism in the genes of HLA loci A, B, C, DRB1, DQB1 by PCR-SSP. The sample group consists of the mothers and newborns with intrauterine growth retardation (IUGR) (20 pairs), hemolytic disease of the newborn (HDN) (21 pairs), after external rotation of the fetus (11 pairs), from women with malignancy (1 pair), autoimmune thrombocytopenia (1 pair), tuberous sclerosis (1 pair), bradyarrhythmias (1 pair). The control group consists of 13 pairs. Of the 138 studied blood samples microchimerism was detected in 33.9 % of patients and in 19.2 % of control group. Maternal microchimerism was found only in patients with perinatal pathology and was not met in the control group. Fetal microchimerism was distributed in all studied groups, but among patients with perinatal pathology, it was met three times more frequent than in the control group (23.9 % and 7.7 %, respectively). Significantly more frequent microchimerism was found in the group of patients with HDN than in the control (p = 0.04). In the other groups the occurrence of the chimeric gene from the control group was not statistically significant
The efficacy of treatment of early stage of iron-deficiency states in children
Authors: Pshenichnaya Ksenia I , Kasatkina Tatyana N
Published: November 2018

The deficiency of iron is one of the most widespread deficits. This deficiency is most common in the growing organism. There is a large quantity of oral therapies to correct deficit of iron. Usage of any of them can cause adverse side effects. In each and every case the pediatrician should have options to choose most optimal course of treatment of the iron deficiency state, including latent iron deficiency as iron deficiency anemia prophylaxis. The article represents data of using medical food complex “Sideral” in treatment of outpatient children. The drug was used on 44 children in age between 6 months and 3 years, who were observed in city’s out-patient hospitals. All of the children had abnormalities in clinical blood analysis, which are specific for mild iron deficiency anemia or latent iron deficiency. The treatment results were evaluated by clinical blood analysis. The positive dynamics was observed in 42 of 44 children. In a month after the treatment start, a tendency to hemoglobin, MCV and MCH levels normalization was detected, the complete normalization occurred in two months. The length of medical food comples “Sideral” usage was similar to such, recommended length of other drugs usage, and was equal to 2 months, while using in latent iron deficiency conditions, and equal to 3 month in mild iron deficiency anemia conditions. The conclusion was made that using this medical food is viable in therapy of children with mild forms of iron-deficiency.
Dynamics of indicators of temporary disability in connection with the care of a sick family member (child)
Authors: Orel Vasily I , Rukavishnikov Alexey S , Danilov Vyacheslav T , Neroda Gennady A , Rubezhov Alexander L , Alekseev Pavel S , Orel Vyacheslav V , Gureva Natalya A , Sharafutdinova Lyubov’ L
Published: November 2018

Examination of temporary disability is one of the types of medical examination which aims to assess the state of health of the patient, the quality and effectiveness of the treatment, the ability to carry out professional activities, as well as determining the extent and timing of temporary disability. A document certifying temporary disability of citizens and confirming their temporary release from work, is sick leave. Piece of disability issued not only in connection with disease of working citizens, but for the period of leave for pregnancy and childbirth, in connection with the quarantine and if necessary care for a sick family member. Examination of temporary disability is the attending physician who alone gives the citizens a sick leave for a period up to 15 calendar days, and in the cases established by the authorized Federal Executive authority, paramedic or dentist that solely give out a leaf of invalidity for the term up to 10 calendar days inclusive. Extension of sick leave for a longer period (but not more than 15 calendar days at a time), by the decision of the medical Commission appointed by the head of the medical organization the number of doctors trained in carrying out examination of temporary disability. This article analyzed the dynamics of morbidity of children population 0-14 years inclusive cases care for this age category with sick leave in Saint Petersburg for the period from 2011 to 2015.
IgE-hypersensitivity to allergens of the fungi Rhizopus Nigricans and Cladosporium Herbarum in childrenwith respiratory allergies
Authors: Gurina Olga P , Dementeva Elena A , Blinov Aleksandr E , Varlamova Olga N , Timokhina Vera I
Published: November 2018

A survey of 111 children diagnosed with respiratory allergies (allergic rhinitis, allergic bronchitis, obstructive bronchitis, recurrent bronchitis, bronchial asthma) aged 1 year to 17 years, of which 58 children have a diagnosis of atopic bronchial asthma of different severity. All children are at risk for the development of fungal sensitization, having a household contact with these allergens. Allergological diagnostics was performed by ELISA using a panel of pediatric and fungal (Rhizopus nigricans and Cladosporium herbarum) biotinylated allergens. As a result of the study revealed that allergens mold Rhizopus nigricans and Cladosporium herbarum are the causal significant factor in the development of respiratory allergies, including asthma, in children at risk. Most often a high level of hypersensivity to Rhizopus nigricans is seen in children aged 2-5 years, Cladosporium herbarum - aged 6-9 years, concomitant to both fungal allergens at the age of 10-17 years. The correlation between the severity of atopic process and degree of sensitization to fungal allergens was not detected. All children with atopic asthma have polyvalent sensitization. Allergens mold Rhizopus nigricans and Cladosporium herbarum must be taken into account in the preparation of a diagnostic panel for children with respiratory allergies at risk. It is necessary to support drug therapy of respiratory allergy in children the activities aimed at elimination of cause significant fungal sensitization everyday surroundings.
Clinical characteristics of newborn with different birth weight (results of a multicenter cohort study)
Authors: Deev Ivan A , Kulikova Kristina V , Kobyakova Olga S , Kulikov Evgeny S , Holopov Aleksandr V , Stepanov Igor A , Antonova Irina N , Bybchenko Elena G , Holtzman Kirill E , Dorovskaja Elena N , Kozhevnikova Ekaterina N , Ledyakina Ludmila V , Makarova Natalia A , Permyakova Maria A , Popova Nadezhda G , Stradina Anna A , Fedorova Larisa A , Fomenko Anna A , Kharitonova Ekaterina S , Khodosevich Ekaterina B , Chugainova Irina N
Published: November 2018

This article is dedicated to analysis of clinical characteristics of children with different birth weight included in the multicenter cohort study of newborns. The study analyzed data 572 children who were stratified according to birth weight (normal, low, very low and extremely low body weight). As part of the protocol incorporating the patient’s visit was provided at the time of birth (visit 0), a retrospective collection of anamnestic data about the mother (Visit -1) and visit prospective study of children aged 12 months (Visit 1). As a result of the analysis, it was found that the increase in frequency of operative delivery, and reduction of Apgar score and the presence of the studied pathological conditions, to the greatest extent, common in children who had birth weight of less than 1500 in this case. The probability of a combination of 3 or more conditions (described in this paper), in the case of a child with an extremely low birth weight was higher in the 44-fold (OR = 44.52; CI95% 15,5-127,5), while when the newborn had very low birth weight - a chance of development was significantly higher only in the 7-fold (OR = 7.12; CI95% 2,4-20,9) compared with children who had a low birth weight. In this regard, there is a need not only to the use of modern technologies nursing of low birth weight infants, but also provide preventive care in a group of women with a high degree of perinatal risk and risk of preterm delivery, allowing prolong pregnancy up to 32 weeks and/or weight of the fruit body of more than 1000 g, which can improve the survival rates of patients and the prevention of premature severe disabling conditions in the future.
Vegetative disfunction and adaptive reserve potential in children born with fetus growth delay in the first 6 months of life
Authors: Ivanov Dmitry O , Kozlova Lyudmila V , Derevtsov Vitaly V
Published: November 2018

In the course of the research we assessed the status of the autonomic nervous system and adaptation in infants with intrauterine growth restriction (IUGR) during the first six months of life. We observed infants born after abnormal pregnancies with IUGR (Group I), infants born after abnormal pregnancies without IUGR (Group II) and virtually healthy infants (without pregnancy and labour complications) in Group III. Despite the complicated medical history, at birth Group I infants displayed the level of sympathetic nervous system activity comparable to the one in Group III infants and lower than the level in Group II infants. However, in Group I infants sympathetic nervous system activity was restricted and compensatory reserves were depleted, sympathicotonia was prevalent. Decrease in frequency of asympathicotonic responsiveness of the autonomic nervous system (from 36.11% to 16.67%) and increase in sufficient adaptation (from 27.78% to 33.33%) in Group I infants by the end of neonatal period of life are related to the treatment of the pregnant women, as we suppose. Despite the fact that by the age of three months the level of sympathetic nervous system activity in Group I infants was lower than that in Group II infants, Group I infants showed less intensive decrease in sympathetic activity level followed by more strain on compensatory reserves. By the age of six months the sympathetic nervous system activity had continued decreasing and was no longer significantly different in Group I and Group II infants. At the same time, Group I infants displayed more frequent hypersympathicotonias combined with asympathicotonic responsiveness of the autonomic nervous system (in 16.36%). The results of the research show that IUGR in infants is connected to high rate of hypersympathicotonia with asympathicotonic responsiveness of the autonomic nervous system, which results in higher frequency and intensity of clinical implications of autonomic nervous system dysfunction.
Elektif olgularda açık ve laparaskopik splenektominin karşılaştırılması
Authors: ÜLKÜ Abdullah , TOPAL Uğur , SARITAŞ Ahmet Gökhan , RENCÜZOĞULLARI Ahmet , AKÇAM Tolga , ERAY İsmail Cem , YALAV Orçun , DALCI Kubilay , AYDIN İshak
Published: November 2018

Amaç: Bu çalışmada elektif splenektomi uygulanan olgularda Açık Splenektomi (AS) ile  Laparoskopik Splenektominin (LS) karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmamıza Çukurova Üniversitesi Tıp Fakültesi Genel Cerrahi Anabilim Dalı’nda 1 Ocak 2013- 1 Ocak 2018 tarihleri arasında elektif splenektomi ameliyatı yapılan 95 hasta dahil edildi. Hastaların demografik bilgileri etyolojik neden, ameliyat süresi, kan kaybı miktarı, preoperatif dönemde dalak boyut ölçümü yapıldı. Laparoskopik cerrahiden açık cerrahiye geçme zorunluluğu, hastanede yatış süresi, postoperatif kan ürünleri replasmanı ve postoperatif gelişen komplikasyonlar incelendi.Bulgular: Çalışmamıza dahil edilen hastaların %79‘una (n=75) açık splenektomi, % 21 ‘ine (n=20) laparaskopik splenektomi olmak üzere toplam 95 olgu dahil edildi. Çalışmaya alınan olgularda ortalama yaş AS’ de 43.0±17 (18-78), LS’ de ise 39.3±13.9 idi (19-62). AS uygulanan olguların 31 tanesi erkek (% 41.3), 44 tanesi ise kadın (%58.7) cinsiyette idi. LS uygulanan olguların 7 tanesi erkek (%35), 13 tanesi ise kadın cinsiyette (%65)  idi. AS uygulanan 75 olgudan 19 (% 25.3) olgu splenomegali, 16 (% 21.3) olgu immün trombositopenik purpura (ITP), 11(% 14.7) olgu kitle,7 (% 9.3) olgu ise Talasemi nedeniyle opere edildi.LS uygulanan 20 olgudan 12 (% 60) olgu ITP, 3 (% 15) olgu Hemolitik anemi, 2 (% 10) olgu ise lenfoma nedeniyle opere edildi. LS’de yatış süresi, kanama miktarı ve dalak boyutu üstün iken; AS’de ameliyat süresi anlamlı derecede üstün bulundu .Sonuç: Komplikasyon oranı, hastanede yatış süresi ve maliyetinin daha az olması nedeni ile LS, OS’ye göre daha güçlü bir alternatiftir.
Ablowitz-Kaup-Newel-Segur Formalism and N-Soliton Solutions of Generalized Shallow Water Wave Equation
Authors: Das Supratim
Published: November 2018

We apply Ablowitz-Kaup-Newel-Segur hierarchy to derive the generalized shallow waterwave equation and we also investigate N-soliton solutions of the derived equation using InverseScattering Transform method and Hirota’s bilinear method.
On F-Polynomial, Multiple and Hyper F-Index of some Molecular Graphs
Authors: Ghobadi Sirous , Ghorbaninejad Mobina
Published: November 2018

A graph can be recognized by a numeric number, a polynomial, a sequence of numbers or a matrix which represent the whole graph, and these representations are aimed to be uniquely defined for that graph. Topological index is a numeric quantity with a graph which characterizes the topology of the graph and is invariant under graph automorphism. In this paper, we compute F-polynomial, Multiple F-index and Hyper F-index for some special graphs.
Prevalence of migraine in patients of allergic rhinitis
Authors: Pai Sunil , Rosario David D. M.
Published: November 2018

Background: Migraine and allergic rhinitis are common disorders. Studies have shown increased frequency of migraine headaches in patients with allergic rhinitis. The aim of this study is to identify how age, sex and degree of allergic sensitization influences the occurrence, severity and treatment outcome of migraine headaches in patients with allergic rhinitis.Methods: The study was conducted between 2014 and 2018 in a tertiary care hospital. 150 patients diagnosed with allergic rhinitis clinically were selected and total serum IgE levels were estimated. These patients were subjected to a detailed history taking to determine the characteristics of headache. All classifiable headache diagnoses had met criteria of the International Classification of Headache Disorders-II-2004. Severity of headache was assessed based on MIDAS score. The data was accessed based on age, sex, serum IgE levels, frequency and severity of migraine attacks and the treatment outcome using statistical methods.Results: The prevalence of migraine in this study was 68% among those who had allergic rhinitis. In this study out 150 patients 111 were females and 39 were males. Comparatively females’ patients 84 (75.7%) were found to be more prone for migraine. Majority patients were in the age group of 20 to 40 years (cumulative percentage of 67.3%). There was a negative correlation between age and IgE levels with r= -0.092. In comparison patients with higher levels of IgE (mean 3633) had more severe headaches. Patients with higher levels of IgE required a longer duration of treatment.Conclusions: This study shows that allergic rhinitis is a risk factor for development of migraine. Apart from high prevalence of migraine in patients with allergic rhinitis it is evident from the study that female sex, younger age group and high degree of allergic sensitization also play an important role as the severity of migraine and treatment course depend on these parameters. Hence the treatment for migraine in patients should aim at reducing the allergic sensitization in addition to concurrent treatment for migraine.
Comparative analysis of early exploration versus conservative approach for management of appendiceal mass
Authors: Kumar Raj , Madeshiya Shivam , Pandey V. K. , Shankhdhar Ashutosh
Published: November 2018

Background: Acute appendicitis is the most common reason for emergency abdominal surgery. Acute appendicitis is ranging from mild inflammation of mucous membrane to gangrene, perforation and peritonitis. Appendicular mass is one of its early complication developing in 2 to 6 % cases of acute appendicitis within 48 hours of attack. Objective of this study was to evaluate the outcome of early surgical exploration and its complications in respect to conservative management followed by interval appendectomy for the management of appendicular mass.Methods: A total 46 cases with clinical feature suggestive of appendicular mass presenting in MLN Medical college, Allahabad were included in study. All cases divided into two equal groups based on mode of management of appendicular mass. Group I (early exploration) and Group II (conservative followed by interval appendectomy).Results: Result will be analysed in terms of hospital stay, morbidity, complications and cost.Conclusions: Early exploration for appendicular mass had advantages of total curative treatment in the index admission, shorter hospital stay, minimal morbidity and ensures early return to work and higher compliance. Operative problems such as localization of appendix, adhesiolysis and bleeding are more pronounced and troublesome with interval appendectomy. Wound infection remains common postoperative complication of early appendectomy in appendicular mass but the rate of wound infection is not so high as to preclude this early operative approach.