bluuebunny/crossref_metadata_2025 huggingface dataset:
Computational study of the strong binding mechanism of SARS-CoV-2 spike and ACE2
Authors: Peng Cheng , Zhu Zhengdan , Shi Yulong , Wang Xiaoyu , Mu Kaijie , Yang Yanqing , Zhang Xinben , Xu Zhijian , zhu weiliang
Published: June 2020

The spike protein of SARS-CoV-2 (SARS-CoV-2-S) helps the virus attach to and infect human cells. With various computational methods applied in this work, the accessibility of its RBD to ACE2, its key residues for stronger binding to ACE2 than the SARS-CoV spike (SARS-CoV-S), the origin of the stronger binding, and its potential sites for drug and antibody design were explored. It was found that the SARS-CoV-2-S could bind ACE2 with an RBD-angle ranging from 52.2º to 84.8º, which demonstrated that the RBD does not need to fully open to bind ACE2. Free energy calculation by an MM/GBSA approach not only revealed much stronger binding of SARS-CoV-2-S to ACE2 (ΔG=-21.7~-29.9 kcal/mol) than SARS-CoV-S (ΔG=-10.2~-16.4 kcal/mol) at different RBD-angles but also demonstrated that the binding becomes increasingly stronger as the RBD-angle increases. In comparison with the experimental results, the free energy decomposition disclosed more key residues interacting strongly with ACE2 than with the SARS-CoV-S, among which the Q493 might be the decisive residue variation (-5.84 kcal/mol) to the strong binding. With the mutation of all 18 different residues of SARS-CoV-S on the spike-ACE2 interface to the corresponding residues of SARS-CoV-2-S, it was found that the mutated SARS-CoV-S has almost the same binding affinity as SARS-CoV-2-S to ACE2, demonstrating that the remaining mutations outside the spike-ACE2 interface have little effect on its binding affinity to ACE2. Simulation of the conformational change pathway from “down” to “up” states disclosed 5 potential ligand-binding pockets correlated to the conformational change. Taking together the key residues, accessible RBD-angle and pocket correlation, potential sites for drug and antibody design were proposed, which should be helpful for interpreting the high infectiousness of SARS-CoV-2 and for developing a cure.
Three Distinct Torsion Profiles of Electronic Transmission Through Linear Carbon Wires
Authors: Garner Marc Hamilton , Bro-Jørgensen William , Solomon Gemma C.
Published: June 2020

The one-dimensional carbon allotrope carbyne, a linear chain of sp-hybridized carbon atoms, is predicted to exist in a polyynic and a cumulenic structure. While molecular forms of carbyne have been extensively characterized, the structural nature is hard to determine for many linear carbon wires that are made in-situ during pulling experiments. Here, we show that cumulenes and polyynes have distinctively different low-bias conductance profiles under axial torsion. We analyze the change of the electronic structure, Landauer transmission, and ballistic current density of the three types of closed-shell molecular carbynes as a function of the torsion angle. Both polyynic, odd-carbon cumulenic, and even-carbon cumulenic carbon wires exhibit helical frontier molecular orbitals when the end-groups are not in a co-planar configuration. This helical conjugation effect gives rise to strong ring current patterns around the linear wires. Only the transmission of even-carbon polyynic wires follows the well-known cosine-squared law with axial torsion that is also seen in biphenyl-type systems. Notably, the transmission of even-carbon cumulenic carbon wires rises with axial torsion from co-planar towards perpendicular orientation of the end-groups. The three distinct transmission profiles of polyynes, odd-carbon cumulenes, and even-carbon cumulenes may allow for experimental identification of the structural nature of linear carbon wires. Their different electron transport properties under axial torsion furthermore underline that, in the molecular limit of carbyne, three different subclasses of linear carbon wires exist.
In silico identification of widely used and well-tolerated drugs as potential SARS-CoV-2 3C-like protease and viral RNA-dependent RNA polymerase inhibitors for direct use in clinical trials
Authors: Gul Seref , Ozcan Onur , asar sinan , Okyar Alper , Barıs Ibrahim , Kavakli Ibrahim Halil
Published: June 2020

Despite strict measures taken by many countries, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be an issue of global concern. Currently, there are no clinically proven pharmacotherapies for coronavirus disease 2019, despite promising initial results obtained from drugs such as azithromycin and hydroxyquinoline. Therefore, the repurposing of clinically approved drugs for use against SARS-CoV-2 has become a viable strategy. Here, we searched for drugs that target SARS-CoV-2 3C-like protease (3CLpro) and viral RNA-dependent RNA polymerase (RdRp) by in silico screening of the U.S. Food and Drug Administration approved drug library. Well-tolerated and widely used drugs were selected for molecular dynamics (MD) simulations to evaluate drug-protein interactions and their persistence under physiological conditions. Tetracycline, dihydroergotamine, ergotamine, dutasteride, nelfinavir, and paliperidone formed stable interactions with 3CLpro based on MD simulation results. Similar analysis with RdRp showed that eltrombopag, tipranavir, ergotamine, and conivaptan bound to the enzyme with high binding free energies. Docking results suggest that ergotamine, dihydroergotamine, bromocriptine, dutasteride, conivaptan, paliperidone, and tipranavir can bind to both enzymes with high affinity. As these drugs are well tolerated, cost-effective, and widely used, our study suggests that they could potentially to be used in clinical trials for the treatment of SARS-CoV-2-infected patients.
Nanometer Scale Spectroscopic Visualization of Catalytic Sites During a Hydrogenation Reaction on a Pd/Au Bimetallic Catalyst
Authors: yin hao , Zheng Liqing , Fang Wei , Lai Yin-Hung , Porenta Nikolaus , Goubert Guillaume , Zhang Hua , Su Hai-Sheng , Ren Bin , Jeremy Richardson O. , Li Jian-Feng , Zenobi Renato
Published: June 2020

Understanding the mechanism of catalytic hydrogenation at the local environment requires chemical and topographic information involving catalytic sites, active hydrogen species and their spatial distribution. Here, tip-enhanced Raman spectroscopy (TERS) was employed to study the catalytic hydrogenation of chloro-nitrobenzenethiol on a well-defined Pd(sub-monolayer)/Au(111) bimetallic catalyst (pH2=1.5 bar, 298 K), where the surface topography and chemical fingerprint information were simultaneously mapped with nanoscale resolution (≈10 nm). TERS imaging of the surface after catalytic hydrogenation confirms that the reaction occurs beyond the location of Pd sites. The results demonstrate that hydrogen spillover accelerates hydrogenation at the Au sites within 20 nm from the bimetallic Pd/Au boundary. Density functional theory was used to elucidate the thermodynamics of interfacial hydrogen transfer. We demonstrate that TERS as a powerful analytical tool provides a unique approach to spatially investigate the local structure-reactivity relationship in catalysis.
In Silico Identification of Potential Allosteric Inhibitors of the SARS-CoV-2 Helicase
Authors: Rowaiye Adekunle , Onuh Olukemi , Asala Titilayo , Ogu Amoge , Bur Doofan , Nwankwo Ezinne , Orji Uchenna , Ibrahim Zainab , Hamza Jamila , Ugorji Adaku
Published: June 2020

The COVID-19 pandemic ravages the globe causing unprecedented health and economic challenges. As the world prospects for a cure, scientists are looking critically at strategic protein targets within the SARS-CoV-2 that have therapeutic significance. One of such targets is the Helicase which is an enzyme that affects all aspects of SARS-CoV-2 RNA metabolism. The aim of this study is to identify small molecules from natural products that have strong binding affinity with and inhibitory activity against an allosteric site (Pocket 26) of SARS-CoV-2 Helicase. Pyrx was used for the in silico molecular docking simulations of SARS-CoV-2 Helicase (QHD43415-12.pdb) against a library of small molecules obtained from edible African plants. Triphenylmethane which had a docking score of -7.4 kcal/mol was chosen as a reference molecule. Virtual screening for oral bioavailability was done based on the molecular descriptors of the compounds as provided by Pubchem. SwissADME, pkCSM, and Molinspiration were used for further screening for molar refractivity, saturation, promiscuity, pharmacokinetic properties, and bioactivity respectively. The Galaxy webserver which uses the GROMACS software was used for the molecular dynamic simulation and analyses. The lead compounds are Gibberellin A12, A20 and A51 obtained from Green peas and the Okra plant. Gibberellin A20 and A51 performed better than the standard. Gibberellin A51 is predicted to show the greatest inhibitory activity against SARS-CoV-2 Helicase. It is recommended that the inhibitory activities of the lead compounds be further investigated.
Controlling Activity by Self-Assembly – Tuning Perylene Bisimide Photocatalysts for the Hydrogen Evolution Reaction
Authors: McDowall Daniel , Greeves Ben , McAulay Kate , Fuentes-Caparros Ana , Thomson Lisa , Khunti Nikul , Cowieson Nathan , Nolan Michael , Wallace Matthew , Cooper Andrew I. , Draper Emily R. , Cowan Alex , Adams Dave , Clowes Rob
Published: June 2020

Amino acid functionalised perylene bisimides (PBIs) form self-assembled structures in solution, the nature of which depends on the local environment. Using a high throughput photocatalysis set-up, we have studied five PBIs for the hydrogen evolution reaction (HER) under a range of conditions (pH and hole scavenger concentration) across 350 experiments to explore the relationship between supramolecular structure and photocatalytic activity. Using small angle X-ray scattering (SAXS), we show that photocatalytic activity is determined by the nature of the self-assembled aggregate that is formed with a correlation between the presence of charged flexible cylindrical aggregates and high levels of H2. Our work highlights the complexity of designing supramolecular photocatalysts, and also the power of tuning activity by the type of aggregate that is formed.
Deciphering the Allosteric Process of Phaeodactylum tricornutum Aureochrome 1a LOV Domain
Authors: Tian Hao , Trozzi Francesco , Zoltowski Brian , Tao Peng
Published: June 2020

The conformational-driven allosteric protein diatom Phaeodactylum tricornutum aureochrome 1a (PtAu1a) di ers from other light-oxygen-voltage (LOV) proteins for its uncommon structural topology. The mechanism of signaling transduction in PtAu1a LOV domain (AuLOV) including flanking helices remains unclear because of this dissimilarity, which hinders the study of PtAu1a as an optogenetic tool. To clarify this mechanism, we employed a combination of tree-based machine learning models, Markov state models, machine learning based community analysis and transition path theory to quantitatively analyze the allosteric process. Our results are in good agreement with reported experimental findings and revealed a previously overlooked C-alpha helix and linkers as important in promoting the protein conformational change. This integrated approach can be considered as a general workflow and applied on other allosteric proteins to provide detailed information about their allosteric mechanisms.
Total Hip Arthroplasty in Femoral Neck Fractures in Zagazig University Hospitals
Authors: Mohamed Mohamed Ibrahim Ashour  , El-Sayed El-Etewy Ahmed Soudy  , Mohamed El-Sadek Attia  , Mohamed Ismail Abd-Elrhman Kotb
Published: June 2020

Femoral neck fractures are common in the geriatric population and are associated with high morbidity and mortality. The worldwide incidence of hip fractures is expected to approach 6.26 million by 2050. Studies showed that the functional outcome and pain scoring improved in cases of femoral neck fracture treated by total hip arthroplasty than any other methods. This study was performed on 18 patients presented with history of fracture neck femur who were admitted to orthopedic department, Zagazig university hospital in the period between January 2019 to December 2019. All cases in this prospective study were treated by THA. Prior to commencing the study, ethical clearance was taken from the Zagazig University hospitals and informed consent was obtained from all patients and their guardians before participation in the study. All the patients were operated through Harding’s approach. Both cemented and un-cemented types of arthroplasty were performed. Functional outcomes of hip were evaluated at 3 months and 6 months after surgery. The studied age ranged between 18-62 years with mean ± SD 41.5±12.4 and (44.4%) of them females and (55.6 %) males. (55.6%) of studied group were from rural areas and (44.4%) of studied group were from urban. Regarding occupation (38.8%) of the studied cases were clerk, (11.1%) were hand worker, (16.6%) were farmer, (5.5%) were student, (22.2%) were house wife and (5.5%) were teacher. 66.7 % of studied group had history of previous fixation. Previous operative fixation for fracture N F were 50 % Cannulated screw, 25 % DHS and 25% IMN. Regarding cause of lesion most frequent were failure of other fixation for N F fracture (66.7%) then acute fracture N F associated with OA (22.2%) and neglected N F fracture (11.1%).
ALIH KODE DAN CAMPUR KODE PENJUAL DAN PEMBELI DI PASAR TRADISONAL NAMLEA
Authors: Yulismayanti, Taufik Maryam Henaulu, Karim, Risman Iye,
Published: June 2020

Abstrak Penelitian ini bertujuan untuk mendeksripsikan alih kode, campur kode, dan faktor penyebab terjadinya campur kode penjual dan pembeli di pasar tradisional Namlea. Penelitian ini adalah penelitian deskkritif kualitatif, yakni penelitian yang dilakukan semata-mata hanya berdasarkan pada fakta yang ada atau fenomena yang secara empiris hidup pada penuturnya. Teknik pengumpulan data yang dilakukan adalah teknik pustaka, simak, dan catat. Teknik pustaka adalah teknik yang menggunakan sumber-sumber tertulis untuk menunjang data peneliti. Data yang telah diklasifikasi dianalisis secara deskriptif kualitatif. Hasil penelitian menunjukkan tiga macam alih kode penjual dan pembeli di pasar tradisional Namlea yakni: 1) Alih kode yang dilakukan penutur; 2) Alih kode dilakukan oleh mitra tutur; dan 3) Alih kode yang dituturkan oleh penutur ketiga. Kemudian faktor penyebab terjadinya campur kode adalah campur kode penyisipan kata dan campur kode penyisipan frasa. Kata Kunci: alih kode, campur kode, pasar, Namlea  AbstractThis study aims to describe the code experts and code mix and the factors that cause the mixing of seller and buyer codes in the traditional namlea market. This research is a qualitative descriptive study, a research conducted solely based on facts or phenomena that empirically live on the speaker. Data collection techniques used were library, refer and note technique. Library technique is a technique that uses written sources to support researchers' data. The data that has been classified is analyzed descriptively qualitatively. The results showed three types of code switching of sellers and buyers in the traditional namlea market, namely: 1) Code switching by the speaker; 2) Code switching is done by the speech partner; and 3) Code switching spoken by the third speaker. then Factors that cause code mixing are mixed word insertion codes and mixed phrase insertion codes. Keywords: code transfer, mix code, market, Namlea
KEPASRAHAN HIDUP TOKOH DALAM CERPEN "TUJUAN: NEGERI SENJA" KARYA SENO GUMIRA DAN CERPEN "SEHARI MENUNGGU MAUT" KARYA ERNEST HAMINGWAY
Authors: N Yeffa Afnita A, Siti Umi Hanik Rika Istianingrum, Yunita Suryani,
Published: June 2020

Abstrak Kepasrahan merupakan salah satu bentuk dari eksistensi hidup manusia. Seperti pada tokoh dalam cerpen “Tujuan: Negeri Senja” karya Seno Gumira Ajidarma dan cerpen “Sehari Menunggu Maut” karya Ernest Hamingway yang memilih pasrah dalam memandang kematian. Tujuan penelitian dalam artikel ini untuk memberikan deskripsi perbedaan dan persamaan mengenai makna kepasrahan yang dialami seorang tokoh dalam cerpen “Tujuan: Negeri Senja” karya Seno Gumira Ajidarma dan cerpen “Sehari Menunggu Maut” karya Ernest Hamingway. Metode yang digunakan adalah metode deskriptif dengan analisis komparatif dengan teori psikologi sastra. Teknik pengumpulan data adalah studi pustaka dengan sumber data berupa cerpen “Tujuan: Negeri Senja” karya Seno Gumira Ajidarma dan cerpen “Sehari Menunggu Maut” karya Ernest Hamingway. Teknik analisis dengan deskriptif interpretatif. Hasil yang ditemukan dalam penelitian ini adalah pada kedua cerpen tersebut terdapat persamaan tema cerita yaitu kematian. Perbedaanya terletak pada karakter tokoh dalam memaknai kepasrahan dengan sikap merelakan, menerima, mengatasi sesuatu, dan melakukan tindakan. Kata-kata kunci: eksistensi, kepasrahan, tokoh, cerita pendek  AbstractSurrender is one form of existence of human life. As in the characters in the short story “Tujuan: Negeri Senja” by Seno Gumira Ajidarma and the short story “Sehari Menunggu Maut” by Ernest Hamingway who chose resignation in looking at death. The purpose of the research in this article is to provide a description of the differences and similarities regarding the meaning of surrender experienced by a character in the short story “Tujuan: Negeri Senja” by Seno Gumira Ajidarma and the short story “Sehari Menunggu Maut” by Ernest Hamingway. The method used is descriptive method with comparative analysis with literary psychology theory. Data collection techniques are literature study with data sources in the form of short stories “Tujuan: Negeri Senja” by Seno Gumira Ajidarma and the short story “Sehari Menunggu Maut” by Ernest Hamingway. Analytical techniques with interpretive descriptive. The results found in this study are in the two short stories there are similarities in the theme of the story that is death. The difference lies in the character's character in interpreting surrender by giving up, accepting, organizing something, and taking action. Keywords: existence, surrender, character, short stories
Klasifikasi Leksikon dan Fungsi Nilai Sosial Ornamen Tradisional Rumah Banjar
Authors: Hestiyana Hestiyana
Published: June 2020

Penelitian ini menganalisis klasifikasi leksikon dan fungsi nilai sosial ornamen tradisional rumah Banjar. Penelitian ini bertujuan mendeskripsikan klasifikasi leksikon dan fungsi nilai sosial ornamen tradisional rumah Banjar. Penelitian ini menggunakan metode deskriptif dengan pendekatan semantik budaya. Sumber data yang digunakan berupa data lisan dan data tertulis mengenai leksikon ornamen tradisional rumah Banjar dan fungsi nilai sosialnya. Pengambilan data dilakukan di Kabupaten Banjar dan Kota Banjarmasin. Hal ini dilakukan berdasarkan nilai sejarah kedua daerah tersebut yang pernah menjadi pusat Kerajaan Banjar. Dalam pengumpulan data digunakan teknik observasi, wawancara, dan dokumentasi. Hasil analisis data disajikan dengan metode penyajian informal, yakni dipaparkan dengan kata-kata serta uraian kalimat. Penelitian ini dapat mengungkap klasifikasi leksikon dan fungsi nilai sosial ornamen tradisional rumah Banjar. Dari hasil penelitian ditemukan bahwa leksikon ornamen tradisional rumah Banjar dapat diklasifikasikan berdasarkan sarana bangunan yang diberikan ukiran atau motif, yaitu (1) pucuk bubungan, (2) pilis atau papilis, (3) tangga, (4) palatar, (5) lawang, (6) lalungkang, (7) watun, (8) tataban, (9) tawing halat, dan (10) sampukan balok. Adapun fungsi nilai sosial ornamen tradisional rumah Banjar, yaitu (1) nilai silaturahmi, (2) nilai gotong royong, (3) nilai tolong-menolong, dan (4) nilai musyawarah.
TUTURAN MANYAMBATI DALAM BAHASA BANJAR
Authors: Yayuk Rissari
Published: June 2020

This study aims to present manyambati utterances in the Banjarese language. The problem is how does the form of violations of politeness utterance manyambati in Banjar language. The purpose of this study is to describe the form of violation of politeness utterance manyambati in Banjar language. It is a qualitative study using a descriptive method. This study uses three steps of work, they are providing data, analyzing data, and presenting data. The technique used in data collection is recording and documentation. The data are taken from January 2019 to March 2019. The place and source of data are taken from people who live in Banjarmasin, Banjarbaru, and Martapura. To analyze the data this study uses the speech act theory. This study uses a descriptive and interpretative technique. The result of data analysis is presented in common words. Based on the results of data analysis, it can be concluded that the form of violations of politeness utterance manyambati in Banjar language consists of mentioning someone's physical deficiency, negative work, names of parents, and dirty objects. These four manyambati utterances have already threatened someone's dignity. The speaker has already violated the principal politeness language.
PRONOMINA PERSONA BAHASA MELAYU AMBON DI WILAYAH TUTUR KOTA AMBON
Authors: Erniati Erniati
Published: June 2020

The objective of this study is to describe the types of personal pronouns in the Ambonese Malay language. This research applies the qualitative descriptive method to analyze the language phenomenon objectively. The research data are oral data taken from communication between the people in Ambon City and its surroundings, which consists of all ages of the Ambonese Malay language speaker.  The data are collected using the observation method, recording, and writing technique. The analysis of selected data is using a descriptive qualitative method. The results show that there are several pronouns of the Ambonese Malay language. They are first-singular personal pronouns, and first-plural personal pronouns; second-singular personal pronouns, and second-plural personal pronouns; third-singular personal pronoun, and third-plural personal pronouns; kinship lexeme personal pronouns.
Performance Evaluation of Two-Link Multirate Loss Models with Restricted Accessibility
Authors: Keramidi Irene P. , Moscholis Ioannis D. , Sarigiannidis Panagiotis G. , Logothetis Michael D.
Published: June 2020

We consider a two-link communication system with restricted accessibility that services Poisson arriving calls of many service-classes and propose a multirate teletraﬃc loss model for its analysis. In a restricted accessibility system, call blocking occurs even if available resources do exist at the time of a call’s arrival. In the two-link system under consideration, each link has two thresholds (oﬄoading and support) which express the in-service calls in a link. The oﬄoading threshold represents the point from which a link oﬄoads calls. The support threshold (which is lower than the oﬄoading threshold) deﬁnes the point up to which a link supports oﬄoaded calls. The two-link system with restricted accessibility is modeled as a loss system whose steady state probabilities do not have a product form solution. However, approximate formulas for the determination of call blocking probabilities are proposed. In addition, we also provide a corresponding analysis related to the case of quasi-random traﬃc (i.e. traﬃc generated by a ﬁnite number of users). The accuracy of all formulas is veriﬁed through simulation and is found to be quite satisfactory.
Extrapolation of Electromagnetic Response from Linear Antennas in Time Domain without Late-Time Instabilities in Numerical Solution of EFI Equation
Authors: Witenberg Anna
Published: June 2020

The paper presents a new hybrid method relied upon to solve integral equations of the electric ﬁeld in time domain and to model linear antennas with pulse excitation. The method consists in a mixed, numerical-analytical description of the process that helps maintain the stability of calculations during the late time phase. As described in the analytical part, the modiﬁed spherical Bessel function of the ﬁrst kind allows for extrapolation with a high degree of accuracy and loworder expressions. The modiﬁed spherical Bessel functions of the ﬁrst kind are of the oscillating character, and their combination with the exponential factor makes them convenient for extrapolation of the answer of the antenna with pulse excitation. New functions are introduced to computational practice.
ADHERENCE TO HAND HYGIENE IN A NEPHROLOGY SERVICE
Authors: Ribeiro Ivonizete Pires , Oliveira Elizana Carvalho , Santos Ana Maria Ribeiro dos , Oliveira Adélia Dalva da Silva , Carvalho Herica Emilia Félix de
Published: June 2020

Objective: To evaluate adherence to hand hygiene in a nephrology service. Method: Descriptive study, performed in a public hospital in Teresina, Piauí, Brazil. Adherence percentage to five moments of hand hygiene was collected in a database of Center for Patient Safety in the period from March to April 2019. Results: Adherence rate varied in all the periods analyzed, reached 25% of adherence, and there were almost no stabilization periods. By relating the variation of adherence rate with the activities performed in the same period, it may be inferred that the greatest number of professionals who participated in educational activities on hand hygiene influenced in the increased adherence rate. Conclusion: The adherence was low; therefore, it is necessary that educational interventions be constant and not punctual so that hand hygiene becomes routine inherent in care.
Pesquisa com Histórias de Vida na Produção da História da Educação em Ciências: o Dispositivo Fotobiográfico como Recurso para a Compreensão de Experiências Sociais
Authors: Borba Rodrigo Cerqueira do Nascimento , Selles Sandra Escovedo
Published: June 2020

O acionamento de fontes históricas e de abordagens metodológicas diversificadas têm sido requisitadas para que novos conhecimentos sócio-históricos possam ser construídos em torno das constituições históricas das disciplinas Ciências e Biologia, possibilitando a compreensão de nuances, controvérsias e disputas. Deste modo, o presente texto almeja apresentar e problematizar a utilização de um recurso investigativo desenvolvido no campo das Ciências Sociais e ainda incomum nos estudos sobre Educação em Ciências em perspectiva histórica: a fotobiografia. Conjugando referenciais da Sociologia, da História do Educação e do Currículo e partindo de uma pesquisa sobre a trajetória social de uma professora de Ciências cujas práticas pedagógicas estiveram em intensa sintonia com os pressupostos do “Movimento de Renovação do Ensino de Ciências” das décadas de 1960 e 1970, é exercitado o uso do dispositivo fotobiográfico para acionar memórias e a produção de outros sentidos que sobre o que seria lecionar Ciências naquela conjuntura.
Лексема присяга та її синоніми в лексикографічних джерелах
Authors: Тарасюк Тетяна , Снітко Анна
Published: June 2020

У статті проаналізовано лексеми на позначення поняття обіцянки дотримуватися певних зобов’язань, клятви вірності якій-небудь справі. З’ясовано, що в сучасній українській мові функціонують іменникові лексеми присяга, обіцянка, обітниця, обіт, клятва, божба, рота із певними заувагами: присяга, обіцянка, клятва – загальновживані, обіт, обітниця, божба і рота – стилістично обмежені, хоча такої диференціації до початку ХХ ст. не зафіксовано. Про частотність використання однієї з названих лексем свідчать сталі словосполучення, наведені у словниках. На прикладі наголошування лексеми присяга проілюстровано позамовні чинники, що впливають на стан акцентуаційної системи української мови. Встановлена важливість етимологічних коментарів окремих укладачів лексикографічних праць, які тлумачать причини та час появи тієї чи тієї лексеми у нашій мові, подають паралелі з інших слов’янських мов, фіксують семантику лексем на певному історичному зрізі.
ІІІ Міжнародна наукова конференція «Лінгвостилістика ХХІ ст.: стан та перспективи розвитку» (м. Луцьк, 2‒4 вересня 2017 року)
Authors: Левчук Ірина
Published: June 2020

2‒4 вересня 2017 року на базі практик табору «Гарт»Східноєвропейського національного університету імені Лесі Українкивідбулася ІІІ Міжнародна наукова конференція «ЛінгвостилістикаХХІ ст.: стан та перспективи розвитку», організована кафедрою історії такультури української мови спільно з Інститутом української мови НАНУкраїни, Університетом ім.Ф. Палацького (м. Оломоуц, Чеська Республіка),Товариством української літератури при Спілці білоруських письменників(м. Мінськ, Республіка Білорусь), Українською науково-педагогічноюспілкою «Берегиня» (Республіка Білорусь).
DETERMINANT OF COMPANY PERFORMANCE IN CONSTRUCTION SERVICE INDUSTRIES IN JAVA ISLAND: GAJAH MADA LEADERSHIP ANALYSIS
Authors: Suharjana I Dewa Ketut , Purwoko Bambang , Umar Husein
Published: June 2020

The aims of this research is to analyze the influence of Strategy Corporate, HRD Strategy, QHSE Management and Leadership on Company Performance in Construction Industry in Java Island. The research design used in this study is a causal design that explains the relationship between variables, supplemented by descriptive analysis to explain data from indicators and dimensions of each variable.The research location in Java Island area, the object of research includes36 companies in construction service industry using 246 managers as a sample. The data of this research are primary data obtained from questionnaires by respondents.The analytical method used for descriptive study and using SPSS software and Structural Equation Modeling (SEM) using Lisrel software for the study of causality between variables.The result of causality analysis indicated that some research hypothesis is rejected, that is Leadership does not influence to Company Performance, Corporate Strategy has no effect to Company Performance, HRM Strategy has no effect to Company Performance and QHSE Management has no effect to Company Performance.

Keywords: HRD Management, Company Strategy, QHSE Management, Leadership, Company Performance
ANALYSIS ON THE INFLUENCE OF TAX PLANNING AND DEFERRED TAX BURDEN ON PROFIT MANAGEMENT (STUDY CASE IN THE MANUFACTURING COMPANY LISTED ON INDONESIA STOCK EXCHANGE YEAR 2014 – 2018
Authors: Samanto Hadi , Pitaloka Nia
Published: June 2020

Purpose-To test the influence of tax planning and tax burden in conducting partial and simultaneous profit management.

Research methodology-The samples are part of a population whose characteristics are to be investigated, and are considered able to represent the entire population (a number less than their number of populations). The process of selecting samples in this research is using the purposive sampling method. The purposive sampling method the determination of the sample based on the criteria formulated first by the researcher.

Conclusion-Tax planning has a positive effect on profit management while deferred tax has no significant effect on partial profit management. The simultaneous tax and deferred tax planning is a positive effect on profit management.

The limitations - Tthese studies are only conducted in manufacturing companies located on the Indonesia Stock Exchange.

Keywords: tax planning, tax expense, profit management
I feel, therefore I am
Authors: Montheiro Adriana
Published: June 2020

This paper appeared originally in Portuguese as Sinto, logo Sou - um estudo sobre o significado das emoções e suas funções. Revista Brasileira de Análise Transacional XXI, 2011, n.1, 29-41 and is reproduced here by kind permission of UNAT-BRASIL - União Nacional de Analistas Transacionais – Brasil.
Emotion is not a concept that can be accurately defined, even if in ordinary language it refers to affective states. The theory of transactional analysis, created by Berne and developed by his followers, is impregnated with the concept of emotion. In order to bring more light to these questions, the present article discusses the biopsychology of emotions, considering their objectives and functions, considering the influence of neuroscience. We also refer to authors who did a theoretical review of transactional analysis from the perspective of biology and the mind, such as Allen and Hine. We have also included authors with a body approach such as Reich and Levine for their significant contributions both to understanding how the scripting system is embedded in the body, and to consider the possibility of developing a systematic body approach within Adult decontamination methodology. We conclude that there are no destructive emotions. Destructive is the way one learns to deal with feelings, with sensations and emotions. And working on emotions is working on lifescript.
Formal and Informal Use of TA Counselling in Education
Authors: Jusik Piotr
Published: June 2020

We thank the previous publishers for permission to re-publish this article, which previously appeared as Jusik, P. (2017) Formal and Informal Use of TA Counselling in Education. Edukacyjna Analiza Transakcyjna, 6, 67-85. We have retained the structure and referencing of that article.
This article applies role theory and thus clarifies the differences between educators and counsellors who use transactional analysis as a method of conceptualising their work to support growth and development of learners. Educators are seen as facilitators of growth that results from acquiring knowledge, skills and understanding, whereas counsellors emphasise growth resulting from introspection based on relational experiences with the practitioner. Furthermore, counselling interventions can be differentiated into formal and informal work that show considerable differences in terms of contract, roles, levels of containment and confidentiality. Several transactional analysis models have been described in the context of formal and informal interventions. Relevant case studies have been presented to show how the concepts are applied in an educational environment. The author suggests that transactional analysis counsellors need to bring awareness into the roles that they hold and their ability to account for role differences will make their interventions more robust.
The Prevalence of Hyperuricemia and Associated Factors in Depok
Authors: Meiyetriani Eflita , Hamzah Hamzah , Lima Florensia
Published: June 2020

Dalam beberapa tahun terakhir telah terjadi peningkatan kejadian hiperurisemia dan hal terakhir ini telah menarik perhatian karena berkaitan dengan penyakit yang berhubungan dengan gaya hidup orang dewasa, bersama dengan hipertensi, diabetes dan dislipidemia. Hasil penelitian terdahulu menunjukkan ada hubungan antara resistensi insulin dan hiperurisemia dengan metabolik sindrom.Belum ada data yang pasti mengenai besarnya angka kejadian hiperurisemia pada masyarakat Indonesia. Penelitian potong lintang ini bertujuan untuk mengetahui prevalensi hiperurisemia dan faktor-faktor yang mempengaruhinya di Kota Depok, Jawa Barat. Penelitian ini merupakan penelitian potong lintang yang dilaksanakan di Kota Depok pada periode bulan Maret 2014 sampai Mei 2014.  Sebanyak 70 orang yang memenuhi kriteria inklusi dan bersedia menjadi responden penelitian terlibat dalam penelitian ini.Uji kai kuadrat dilanjutkan dengan analisis multivariat uji regresi logistik dilakukan untuk mendapatkan faktor-faktor yang berhubungan dengan hiperurisemia. Sebanyak 18,6% mengalami hiperurisemia dimana frekuensi yang lebih sering pada laki-laki, usia di atas 50 tahun, pendidikan akhir sekolah dasar, tidak bekerja dan memiliki riwayat mengonsumsi makanan yang mengandung tinggi purin. Analisis multivariat menunjukkan hubungan yang signifikan antara jenis kelamin, usia, pekerjaan dan riwayat konsumsi purin. Oleh karena prevalensi hiperurisemia yang relatif tinggi maka disarankan perubahan perilaku konsumsi makan dan kontrol terhadap kosumsi purin yang dapat meminimalisir terjadinya kondisi ini. Lebih lanjut disarankan untuk banyak minum dan makan buah-buahan, menghindari stress dan melakukan aktivitas fisik secara teratur.
ANATOMI DAN GAMBARAN KLINIS VARIKOKEL
Authors: Al Muqsith Al Muqsith
Published: June 2020

Varikokel merupakan dilatasi abnormal pleksus pampiniformis yang terjadi pada 15% pria. Varikokel lebih sering terdeteksi pada populasi pria infertil dibandingkan dengan pria fertil, terdiagnosis pada 20-40% pasien infertil. Umumnya dijumpai pada anak remaja dan pria dewasa. Adanya varikokel dikaitkan dengan kegagalan dari fungsi testis. Artikel ini ditulis untuk menjelaskan gambaran klinis varikokel. Dengan mengetahui gambaran klinis dari varikokel diharapkan para klinisi dapat lebih mudah dan cepat mendiagnosis serta memberikan penatalaksanaan yang tepat sehingga memberikan prognosis yang baik untuk penderita. Gambaran klinis yang sering dijumpai pada pasien varikokel berupa benjolan di atas testis dan nyeri pada testis. Varikokel dapat didiagnosis dengan melakukan beberapa pemeriksaan seperti pemeriksaan fisik dan pemeriksaan penunjang. Pemeriksaan Ultrasonografi merupakan pilihan pertama, non invasif dan akurat dalam mendeteksi varikokel.
KORELASI DERAJAT OBESITAS DENGAN RISIKO TERJADINYA OBSTRUCTIVE SLEEP APNEA (OSA) PADA REMAJA SMA NEGERI DI KECAMATAN BANDA SAKTI KOTA LHOKSEUMAWE 2018
Authors: Mauliza Mauliza , Fardian Nur , Gunawan Surya
Published: June 2020

Obstructive Sleep Apnea (OSA) merupakan suatu kelainan pernapasan selama tidur yang ditandai dengan obstruksi saluran napas atas parsial atau obstruksi total intermiten yang mengganggu ventilasi dan pola tidur normal. Terdapat berbagai faktor yang bisa menyebabkan OSA. Obesitas adalah salah satu faktor risiko terjadinya OSA. Tujuan penelitian ini untuk mengetahui adakah korelasi antara derajat obesitas dengan risiko terjadinya obstructive sleep apnea pada remaja SMAN di Kecamatan Banda Sakti Kota Lhokseumawe. Jenis penelitian ini adalah analitik dengan pendekatan cross sectional. Populasi dalam penelitian ini adalah seluruh siswa-siswi obesitas yang bersekolah di SMAN Kecamatan Banda Sakti dengan jumlah sampel 71 orang diambil dengan teknik total sampling. Data dikumpulkan melalui kuesioner Berlin, Indeks Massa Tubuh (IMT), dan di analisis secara univariat dan bivariat. Hasil statistik menggunakan uji somers’d menunjukkannilai p=0,000 (α=0,05). Kesimpulan penelitian ini adalah Ho ditolak artinya terdapat korelasi antara derajat obesitas dengan risiko terjadinya obstructive sleep apnea pada remaja SMAN di Kecamatan Banda Sakti Kota Lhokseumawe.
D-8 ÜLKELERİNDE İŞSİZLİK VE İKTİSADİ BÜYÜME İLİŞKİSİNİN PANEL NEDENSELLİK ANALİZİ
Authors: YAYAR Rüştü , ÖZTAŞ Betül
Published: June 2020

İşsizlik oranını azaltmak ve yüksek bir büyüme oranı gerçekleştirmek bütün ekonomilerin en önemli amaçlarıdır. Bu çalışmada işsizlik ve iktisadi büyümenin ne olduğu ve bu kavramlar arasındaki ilişki açıklanmaya çalışılmıştır. D-8 ülkeleri için işsizlik ve iktisadi büyüme arasındaki ilişki 1998-2017 dönemine ait yıllık verilerle incelendiği bu çalışmada panel nedensellik analizi kullanılmıştır. Analiz sonuçlarına göre Endonezya’da %1 anlamlılıkta ve Türkiye’de ise %5 anlamlılıkta iktisadi büyümeden işsizlik oranına doğru bir nedensellik ilişkisinin olduğu tespit edilmiştir. İşsizlik oranından iktisadi büyümeye doğru nedensellik ilişkisine bakıldığına ise D-8 ülkelerinin hiçbirinde işsizlik oranının iktisadi büyümenin nedeni olmadığı sonucuna ulaşılmıştır.
VERGİ TEŞVİKİ UYGULAMASININ YATIRIM ÇIKIŞLARI ÜZERİNDEKİ ETKİSİ: GELİŞMEKTE OLAN ÜLKELER İÇİN PANEL VERİ ANALİZ
Authors: KUTBAY Hüseyin
Published: June 2020

Bu çalışmanın amacı, vergi teşviki uygulamaları ile doğrudan yabancı yatırım çıkışları arasındaki ilişkiyi 2007-2018 dönemi yıllık veriler kullanarak gelişmekte olan 42 ülke için tahmin etmektir. Çalışmada vergi teşviki uygulamalarının ve vergi teşviki uygulamaları ile birlikte ticari dışa açıklığın, ekonomik özgürlüğün ve kişi başına GSYH’nin doğrudan yabancı yatırım çıkışları üzerindeki etkisini tahmin etmek için iki model oluşturulmuştur. Seriler arasında yatay kesit bağımlılığı olmadığı için, serilerin durağanlıkları birinci nesil panel birim kök testleri ile incelenmiştir. Kurulan her iki modelde de sabit etkiler modelinin geçerli olduğu belirlenmiştir. Seriler arasında değişen varyans ve oto-korelasyon sorunu tespit edilmiştir. Bu yüzden bu sorunlar altında dirençli tahminler yapabilen Arellano (1987), Froot (1989) ve Rogers (1993) modeli kullanılmıştır. Analiz neticesinde yalnızca vergi teşviki uygulamasının doğrudan yabancı yatırım çıkışları üzerinde bir etkisinin olmadığı, diğer değişkenlerle beraber analiz edildiğinde bir anlamının olduğu tespit edilmiştir.
COVID-19 PANDEMİSİ DÖNEMİNDE ÜLKELERİN COVID-19, SAĞLIK VE FİNANSAL GÖSTERGELER BAĞLAMINDA SINIFLANDIRILMASI: HİYERARŞİK KÜMELEME ANALİZİ
Authors: TEKİN Bilgehan
Published: June 2020

Yeni tip Koronavirüs (SARS-CoV-2) hastalığı; hastalar, sağlık çalışanları, sağlık sistemleri ve ekonomiler üzerinde yıkıcı sonuçlar yaratarak dünyada yayılmaya devam etmektedir. Salgının etkisi çoğu ülkede benzer sonuçlara sebep olsa da farklılıklar da söz konusudur. Bu çalışmada, COVID-19 salgınının ülkelere etkileri bağlamında kümeleme analizi gerçekleştirilmiştir. Çalışmada kullanılan değişkenler, bir milyon nüfus başına vaka, test ve ölüm sayıları, bazı finansal göstergelerin değişim oranı ve salgın öncesi ülkelerin sağlık göstergelerinin düzeyidir. Çalışmada finansal göstergeler Ocak 2020 ile Nisan 2020 tarihleri arasındaki değişimleri yansıtmaktadır. COVID-19 göstergeleri ise güncel verilerden alınmıştır. Çalışmada kullanılan değişkenler Dünya Sağlık Örgütü, Dünya Bankası ve OECD’den elde edilmiştir. Çalışmada kümeleme analizi yöntemlerinden hiyerarşik kümeleme ve Ward’s yöntemi kullanılmıştır. Çalışmada ülkelerin söz konusu göstergeler bağlamında benzerlikleri ve farklılıkları ortaya konulmaya çalışılmıştır. Çalışmada hiyerarşik kümeleme yöntemi ile dört farklı veri setinden oluşan veriler kullanılarak dört farklı kümeleme analizi gerçekleştirilmiştir. Çalışma sonucunda ortaya çıkan yedili, beşli, dörtlü ve üçlü küme yapıları karşılaştırılmış ve yorumlanmıştır.
THE EFFECT OF DENSITY TO THE SURVIVAL RATE, GROWTH AND BIOCHEMICAL COMPOSITION OF FEMALE MANGROVE CRAB (SCYLLA OLIVACEA) CULTIVATED WITH SILVOFISHERY SYSTEM
Authors: Karim Muhammad Yusri , Amri Khairul , Azis Hasni Yulianti , Nurfadilah  , Alimuddin  , Usman Zainal
Published: June 2020

Mangrove crab silvofishery system is one of the potential aquaculture activities to be developed because it is supported by the availability of extensive mangrove areas. This research was carried out in the Mangrove Area of Mandalle Village, Pangkep Regency, South Sulawesi. The study was aimed to determine the best density of survival, growth, and chemical composition of the body of female mangrove crabs (Scylla olivacea) maintained by the silvofishery system. The research container used a step cage made of bamboo measuring 2.25 m2 wide. Tested animals used were female mangrove crabs measuring 155 ± 1.0 g which were kept for 40 days. The study was designed using a randomized block design consisting of four density treatments with three replications each. The four densities were: 5,10, 15 and 20 crabs/cage. The results of the analysis of variance showed that the difference in density has a very significant effect (p <0.01) on the survival, growth and biochemical composition of the female body of mangrove crabs. The best survival, growth, and biochemical composition produced the best density of 5 and 10 individuals, while the lowest density was 20 individuals.
VEITSMAN’S THEOREM ON SPACES AND FORCES FORMING THEM, TIME AND CHAOS
Authors: Veitsman Emil V.
Published: June 2020

Some consequences follow from Veitsman’s theorem. It is supposed that our physical time is a criterion characterizing the flow of any fundamental process. It is supposed as well that physical time in space defines from the state of the system under study, e.g., of Universe. If the space is in equilibrium then there is no time known to us from physics in it. The physical time appears in case when the energy expenses take place during the process flowing in space studied. If the space is anisotropic then the time is to be a tensor of rank 2 when its off-diagonal components equal zero. The anisotropy of the space and the change of the physical time passage lead to the breach of the causal connections in the system under study and, as a result, to chaos in it.
REMOVAL OF LOW CONCENTRATION OF KEROSENE FROM WATER USING NIPA PALM (NYPA FRUITICANS WURMB) FRUIT FIBRE
Authors: Adowei Pereware , Wariboko Edward , Markmanuel Douye
Published: June 2020

Nipa palm fruit fibre was carbonized at 400oC in a muffle furnace and used to remove kerosene in contaminated water in a batch experimental process with chemical oxygen demand (COD) reduction as the measurement parameter. The elimination of kerosene in the contaminated water was studied by applying the effect of carbon dosage and initial contaminant concentration. The results obtained showed that, the best process conditions for removing kerosene in the contaminated water samples were 8.0 mg carbon dosage at low concentration of 20 mg/L of kerosene contamination. The adsorption isotherm of the elimination process was evaluated by Langmuir and Freundlich isotherm models and the data fitted better to Freundlich isotherm (R2 = 0.84) when compared to Langmuir isotherm (R2 = 0.88). The maximum monolayer surface coverage as computed from the Langmuir equilibrium adsorption data was 1.43 mg/g.  The overall outcome indicates that the carbonized carbon produced from Nipa palm fruit fibre has low ability in reducing kerosene from contaminated water.
Gonzales, Roberto G., Nando Sigona, Martha C. Franco, and Anna Papoutsi, Undocumented Migration: Borders, Immigration Enforcement, and Belonging
Authors: Garcia Maria Fernanda Mosquera
Published: June 2020

Book review
Dicotomía Parte 1
Authors: Maya José María
Published: June 2020

Se presenta el caso de una paciente de 62 años, con polisintomatología asociada a problemas crónicos de salud, que consulta al médico internista. El médico le ordena exámenes de diferente índole y exige la realización de estos en las instituciones que él indica a la paciente, a pesar de que esta insiste en realizarlos en una clínica conocida cerca de su sitio de residencia. La paciente se entera de que el médico recibe estímulos económicos por la remisión y lo denuncia. Se analiza la falta ética que se configura, denominada dicotomía, con sus diferentes variantes, el riesgo que representa para un ejercicio de la medicina con profesionalismo y ética y se explica la prohibición de esta práctica por la Ley 23 de 1981 o Ley de Ética Médica de Colombia.
La durometría en la valoración de la psoriasis en placas, un estudio exploratorio
Authors: Quintero Jhonatan , Jaramillo-Ayerbe Felipe , Hoyos Ana María , Chacón José Arnoby
Published: June 2020

Introducción: La psoriasis exhibe cambios biomecánicos en la dureza de la piel; no existen marcadores para medir su actividad y su seguimiento se basa en la ‘clinimetría’. Una de las deficiencias del PASI (Psoriasis Area Severity Index) es la interdependencia entre sus variables y la controversia al definir la induración de la placa, según su altura o su semiología. El durómetro, un aparato que mide la dureza de materiales, fue probado por primera vez para medir esta característica.Métodos: Dos evaluadores con un durómetro calibrado de fábrica, midieron en unidades de dureza placas de psoriasis y piel ‘sana’ como control. Los resultados se analizaron con la t de Student y el ANOVA para grupos pareados con medidas repetidas, el coeficiente de correlación de Pearson y la varianza de Fisher, y la correlación y la concordancia con regresión lineal e índice kappa.Resultados y conclusiones: Se midieron 33 placas de 13 pacientes con un PASI promedio de 11. Los evaluadores obtuvieron un coeficiente de Pearson de 0,37 para la durometría y de 0,22 para el PASI. La varianza fue mayor de 20 entre las placas y la piel sana. Entre evaluadores, el coeficiente de Pearson fue de 0,95 y el índice kappa de 0,88 con un índice de confianza del 95 % y una p menor de 0,05. La durometría no se correlacionó con el PASI. Sin embargo, es factible una recalibración en su función, mediante más estudios con una muestra de mayor tamaño y analizando los efectos del esquema terapéutico en el tiempo. La durometría es útil en la valoración de la dureza de la placa de psoriasis, con adecuadas correlación y concordancia entre evaluadores.