bluuebunny/crossref_metadata_2025 huggingface dataset:
Pre-Existing HSV-1 Immunity Enhances Anticancer Efficacy of a Novel Immune-Stimulating Oncolytic Virus
Authors: Ding Jun , Murad Yanal M. , Sun Yi , Lee I-Fang , Samudio Ismael , Liu Xiaohu , Jia William Wei-Guo , Zhao Ronghua
Published: October 2022

Oncolytic viruses (OVs) can specifically replicate in the host and cause cancer cell lysis while inducing an antitumor immune response. The aim of this study is to investigate the impact of either pre-existing immunity against herpes simplex virus type-1 (HSV-1) or multicycle treatment with OVs on anticancer efficacy of VG161, an HSV-1 OV in phase 2 clinical trial. VG161 efficacy was tested in CT26 mouse models by comparing the efficacy and immune response in naïve mice or in mice that were immunized with VG161. Moreover, VG161 efficacy in HLA-matched CD34+ humanized intrahepatic cholangiocarcinoma (ICC) patient-derived xenograft (PDX) models was also tested in multicycle treatment and was compared to standard chemotherapy for this type of cancer (gemcitabine). The HSV-1-immunized mice significantly inhibited tumor growth in VG161-treated mice compared to control naïve treated mice. RNA expression profiling and ELISPOT analyses indicated changes in the tumor’s immune profile in the immunized and treated group compared to naïve and treated mice, as well as enhanced T cell function depicted by higher numbers of tumor specific lymphocytes, which was enhanced by immunization. In the ICC PDX model, repeated treatment of VG161 with 2 or 3 cycles seemed to increase the anticancer efficacy of VG161. In conclusion, the anticancer efficacy of VG161 can be enhanced by pre-immunization with HSV-1 and multicycle administration when the virus is given intratumorally, indicating that pre-existing antiviral immunity might enhance OV-induced antitumor immunity. Our results suggest potential clinical benefits of HSV-1-based OV therapy in HSV-1-seropositive patients and multicycle administration of VG161 for long-term maintenance treatment.
Inflammatory and Hemostatic Markers in COVID-19 Patients with Arterial Thrombosis Are Significantly Lower at Hospital Admission than in COVID-19 Patients without Thrombosis
Authors: de Oliveira Miguel , Cubal Francisco , Coutinho Maria , Pereira Mónica , Cruz Eugénia , Morais Sara
Published: October 2022

Patients with Coronavirus disease 2019 (COVID-19) are at increased risk of venous thromboembolism (VTE); however, data on arterial thromboembolism (ATE) is still limited. We report a case series of thromboembolic events (TE) in 290 COVID-19 patients admitted between October and December 2020 to a Portuguese hospital. Admission levels of various laboratory parameters were evaluated and compared between COVID-19 patients with (TE) and without thrombotic events (non-TE). The overall incidence of isolated ATE was 5.52%, isolated VTE was 2.41% and multiple mixed events was 0.7%. A total of 68% events were detected upon admission to the hospital with 76% corresponding to ATE. Admissions to the Intensive Care Unit were higher in patients with TE, when comparing with the non-TE group (44% vs. 27.2%; p = 0.003). Patients with ATE presented significantly lower levels of CRP (p = 0.007), ferritin (p = 0.045), LDH (p = 0.037), fibrinogen (p = 0.010) and higher monocyte counts (p = 0.033) comparatively to the non-TE patients. These results point to an early occurrence of TE and an increased incidence of ATE over VTE. The less prominent inflammation markers in patients with TE and the early presence of TE in patients with otherwise no reason for hospitalization, may suggest a direct role of SARS-CoV-2 in the thrombotic process.
Autoimmune Rheumatic Disease Flares with Myocarditis Following COVID-19 mRNA Vaccination: A Case-Based Review
Authors: Lai Yi Wye , Chua Choon Guan , Lim Xin Rong , Francis Prabath Joseph , Xu Chuanhui , Howe Hwee Siew
Published: October 2022

Since the introduction of coronavirus disease 2019 (COVID-19) messenger ribonucleic acid (mRNA) vaccines, there have been multiple reports of post-vaccination myocarditis (mainly affecting young healthy males). We report on four patients with active autoimmune rheumatic diseases (ARDs) and probable or confirmed myocarditis following COVID-19 mRNA vaccination managed at a tertiary hospital in Singapore; we reviewed the literature on post-COVID-19 mRNA vaccination-related myocarditis and ARD flares. Three patients had existing ARD flares (two had systemic lupus erythematosus (SLE), one had eosinophilic granulomatosis polyangiitis (EGPA)), and one had new-onset EGPA. All patients recovered well after receiving immunosuppressants comprising high-dose glucocorticoids, cyclophosphamide, and rituximab. Thus far, only one case of active SLE with myocarditis has been reported post-COVID-19 mRNA vaccination in the literature. In contrast to isolated post-COVID-19 mRNA vaccination myocarditis, our older-aged patients had myocarditis associated with ARD flares post-COVID-19 vaccination (that occurred after one dose of an mRNA vaccine), associated with other features of ARD flares, and required increased immunosuppression to achieve myocarditis resolution. This case series serves to highlight the differences in clinical and therapeutic aspects in ARD patients, heighten the vigilance of rheumatologists for this development, and encourage the adoption of risk reduction strategies in this vulnerable population.
Analysis of a Fractional-Order COVID-19 Epidemic Model with Lockdown
Authors: Denu Dawit , Kermausuor Seth
Published: October 2022

The outbreak of the coronavirus disease (COVID-19) has caused a lot of disruptions around the world. In an attempt to control the spread of the disease among the population, several measures such as lockdown, and mask mandates, amongst others, were implemented by many governments in their countries. To understand the effectiveness of these measures in controlling the disease, several mathematical models have been proposed in the literature. In this paper, we study a mathematical model of the coronavirus disease with lockdown by employing the Caputo fractional-order derivative. We establish the existence and uniqueness of the solution to the model. We also study the local and global stability of the disease-free equilibrium and endemic equilibrium solutions. By using the residual power series method, we obtain a fractional power series approximation of the analytic solution. Finally, to show the accuracy of the theoretical results, we provide some numerical and graphical results.
Geometric Path Plans for Perpendicular/Parallel Reverse Parking in a Narrow Parking Spot with Surrounding Space
Authors: Han Inhwan
Published: October 2022

This study proposes geometric path plans composed of two stages to automatically perform perpendicular and parallel parking with a reverse path in a narrow space. In perpendicular parking, the minimum width of the available parking spot is computed before the start of the parking operation, and the availability of parking and the optimal stage of the path plan are determined by considering the surrounding space together. In a similar concept, even in parallel parking, it is possible to determine whether to park by calculating the minimum length of the available parking spot and the number of repetitions of motion before starting the parking operation. The theoretical results for the parking spot and surrounding space related to the geometric path plans of perpendicular and parallel parking were confirmed through model car tests. Efficient automatic parking will be enabled by selecting and establishing an appropriate path plan along with the availability of parking in consideration of the parking spot and the surrounding space before starting the parking operation.
On Approximation Properties of Gamma Type Operator Based on (p,q)-İnteger
Authors: KARABIYIK Ümit
Published: October 2022

In the literature; extensive work on the q and (p,q)-calculus has contributed greatly to describing the different generalizations of many operators involving the q and (p,q)-integers. In this study, we will present to you, that we define Gamma type operator based on (p,q)-integer. We get some direct output including asymptotic formula and error estimation in terms of modulus continuity. In addition, as a result of the research, we estimate the convergence rate of these operators in a weighted space.
Molecular Biological Investigation of The Effect of Aloe vera on The Growth of Saccharomyces cerevisae
Authors: GÖK Özlem , BEYAZ Seda , ASLAN Abdullah
Published: October 2022

Aloe vera (A. vera) tropikal, kuraklığa dayanıklı bir sukulent bir bitkidir. A. vera bitkisi, çeşitli gıdalarda besin takviyesi olarak ve kozmetik ürünlerinde bir bileşen olarak kullanılmaktadır. Anti-inflamatuar, anti-kanser, anti-oksidan, anti-diyabetik ve yara iyileşmesi gibi biyolojik aktivitelere sahiptir. Bu yüzden çalışmamızda A. vera jelinin sisplatin (Cis) kaynaklı Saccharomyces cerevisiae (S.cerevisiae) kültüründe oksidatif hasar üzerindeki etkisi incelenmiştir. Çalışmamızdaki gruplarımız; Grup (1): Kontrol grubu; Grup (2): A. vera Grubu (%10); Grup (3): Cis Grubu (15 mM); Grup (4): A. vera (% 10) + Cis (15 mM) Grubu. Hücre gelişim ölçümleri, lipit peroksidasyonu malondialdehit (MDA) analizleri, glutatyon (GSH) seviyeleri ve katalaz (CAT) aktiviteleri spektrofotometre ile tespit edilmiştir. Total protein değişiklikleri SDS-PAGE elektroforezi ile belirlenmiş ve Bradford metodu ile hesaplanmıştır. Elde edilen sonuçlara göre; S.cerevisiae kültürlerine ilave edilen A. vera jel hücre gelişimini (1, 3, 5 ve 24 saat), total protein sentezini (24 saat), GSH seviyelerini (24 saat) ve CAT aktivitelerini (24 saat) arttırdığı, MDA düzeyini (24 saat) azalttığı tespit edilmiştir. Bu sonuçlar, A. vera jelinin S. cerevisiae kültüründe oksidatif hasarı azalttığını, protein sentezini teşvik ettiğini ve hücre büyümesini arttırmak için koruyucu bir etkiye sahip olduğunu göstermektedir.
The Usability of Waste Sour Cherry Kernel Pyrolytic Oil as Alternative Fuel in Diesel Engines
Authors: YALÇIN Arif Hakan , MUTLU İbrahim
Published: October 2022

Bu çalışmada, piroliz yöntemiyle atık vişne çekirdeklerinden elde edilen pirolitik yağ (PY) fizikokimyasal olarak karakterize edildi. PY’nin fizikokimyasal yakıt özellikleri dizel ile kıyaslandığında yetersiz olduğu görüldü. Bu nedenle PY'nin dizel motorlarda alternatif bir yakıt olarak kullanılabilmesi için modifiye edilmesi gerekmekteydi. Yakıt özelliklerini iyileştirmek için PY’yi dizel ile karıştırmak iyi bir yaklaşım olabilirdi. Ancak PY dizel ile doğrudan homojen olarak karışmadı. PY'yi dizel ile homojen olarak karıştırmak için organik bir çözücü gerekliydi. Bu yüzden, n-bütanolü yardımcı bir çözücü olarak kullanarak çeşitli ağırlık oranlarında (ağırlıkça %) PY ile dizel karışımlarını başarılı bir şekilde hazırladık. Üçlü karışımların homojen olarak karışım sağlaya bilirliği, 48 saat sonra değerlendirildi. Sonuçlar, n-bütanol kullanılarak çok çeşitli kararlı homojen PY ve dizel karışımları yaratmanın mümkün olduğunu ortaya koyan üçlü faz diyagramında gösterildi. Karışım yakıtlar fizikokimyasal özellik yönünden PY'ye kıyasla artan kalorifik değer ve setan sayısı ve azalan kinematik viskozite, yoğunluk ve su içeriği gösterdi. Ancak setan sayısındaki artış dizele kıyasla optimum değerde olmadığı için karışımlara setan arttırıcı olarak 2-EthylhexylNitrate (2-EHN) ilave edildi. Böylece karışım yakıtların setan sayıları yaklaşık %84 oranında iyileştirildi. Sonuç olarak fizikokimyasal özellik yönünden ağırlıkça %40 dizel içeren (PY/Dizel/N-Bütanol/2-EHN) karışım yakıtların bir dizel motorunda alternatif bir yakıt olarak kullanılabileceği belirlendi.
Clumped Isotope Signatures of Dolomites as Reservoir Rocks, Southeast Anatolia
Authors: ATASOY Deniz , GEÇER Aylin , AKTOSUN Arzu , GEÇER BÜYÜKUTKU Aynur
Published: October 2022

Yeni nesil bir jeotermometre yöntemi olan kümelemiş izotop tekniği derin gömülmüş kayaçların diyajenetik süreçlerinin iyi anlaşılması kabiliyetine sahiptir. Bu yöntem kullanılarak, Kambriyen-Eosen yaş aralığındaki altı birimden, ~1-3.2 km gömülme derinliğine sahip toplamda 28 adet dolomit üzerinde ölçüm yapılmıştır. Bu çalışmada, bölgesel olarak seçilmiş Güneydoğu Anadolu rezervuarlarının karot ve sondaj kesintilerinden elde edilen dolomit örneklerinin paleosıcaklıkları ve dolomitleşme sularının δ18O değerleri belirlenmiştir. Kümelenmiş izotop yöntemi ile 37.2-161.9oC aralığında değişen sıcaklık değerleri ve +0.9-9‰ aralığında değişen dolomitleşme sularının δ18O değerleri bulunmuştur. Bu çalışma petrografik destekli olarak, paleosıcaklık ve dolomitleşme sularının δ18O d dağılımlarının dört farklı grup altında toplandığını kanıtlarıyla ortaya çıkarmıştır. İlk grup, Hoya Formasyonu için 43±7oC olarak erken dolomitleşme sıcaklığını ve Mardin Grubu-ED için 53 oC kısmi yeniden kristallenme sıcaklıklarını yansıtmaktadır. Bu değerler depolanma yüzeyindeki yoğun buharlaşma ve/veya sığ gömülme olayıyla ilişkilidir. İkinci grubu oluşturan Cudi Grubu dolomitleri, 64.3oC-93.8oC arasında değişen sıcaklık ve 9‰’e varan δ18Osu değerleri sağlamaktadır. Bu değerler, oldukça yoğun buharlaşmış deniz sularının meydana getirdiği yeniden kristallenme olayını temsil etmektedir. Üçüncü grubu oluşturan Mardin Grubu-GD ve Koruk Formasyonu dolomitlerinin kümelenmiş izotop sinyalleri 134.5oC-8‰’e varan sıcaklıklık ve δ18Osu değerlerine dönüştürülmüşlerdir. Bu değerler derin gömülme koşulları altında tamamlanmış yeniden kristallenme olayı ile karakterize edilmektedirler. En yüksek sıcaklık ve δ18Osu değerlerine sahip son grubun değerleri ise 140oC ve +6.5‰’i aşmaktadır. Bu sonuçlar kalın ve masif dolomit oluşumlarından sorumlu olan hidrotermal suların varlığını gösterdiği şeklinde yorumlanmaktadır. Sonuç olarak, bu araştırma petrol rezervuarlarını meydana getiren dolomitleşme olayının şifrelerini çözmeye yardımcı olan kümelenmiş izotop yönteminin yüksek potansiyelini ortaya çıkarmaktadır.
Implementation of Machine Learning Approaches for Crystal Structure Estimation in Lithium-ion Battery Cathode Materials
Authors: KULU - SÜPÜRTÜLÜ Meltem , DİNDAR Çiğdem , AKYÜZ Recep
Published: October 2022

It has commonly been assumed that the physical and chemical characteristics of lithium-ion silicate cathodes are influenced significantly by the crystal structure system. Because of this, crystal structure estimation has played a vital role in bringing about forecasting many other features of cathodes in battery applications. Using a variety of classification techniques in machine learning which three primary crystal structure (monoclinic, orthorhombic, and triclinic) of silicate-based cathode materials with compound systems of Li-Si-(Mn,Fe,Co)-O has been estimated. The computations are based on the Materials Project's density functional theory computations. In this study, it has been explained that based on property evaluation in statistical models, the considerable correlation between the crystal system and other physical characteristics of the cathodes was validated. Furthermore, the parameters of several categorization techniques have been tuned in order to achieve maximum prediction accuracy. This case has shown that the XGBoost and Support Vector Classifier algorithms carried out in this study the highest forecasting accuracy in this study along with many other classification methods in cross-validation tests.
Evaluation of Physico-Mechanical Properties of Uşak-Karahallı Marbles with Their Mineralogical-Petrographic Properties
Authors: ALPEREN Ayşe Nur , ÇELİK Haluk , BAĞCI Metin
Published: October 2022

Bu makalede Uşak İli Karahallı İlçesinde üç farklı mermer ocağından alınan numuneler üzerinde gerçekleştirilen bir dizi deneysel çalışmalar ile yöre mermerlerinin özellikleri belirlenmiştir. Numunelerin standartlara uygun biçimde saptanan fiziksel ve mekanik özellikleri; kimyasal, mineralojik ve petrografik özellikleri ile değerlendirilmiştir. Karahallı mermerlerinin birim hacim ağırlığı 2.69 gr/cm3 ile 2.74 gr/cm3 arasında değişim göstermektedir. Atmosfer basıncında ağırlıkça su emme değerleri ise %0.27-0.35 arasındadır. Karahallı mermerlerinde yapılan mekanik deneylerden tek eksenli basınç dayanımlarının 874.8 kg/cm2 ile 1027.9 kg/cm2 arasında değişmekte olduğu belirlenmiştir. Böhme aşınma dayanım değerleri ise 4.23 cm3/50 cm2 ile 5.50 cm3/50 cm2 arasındadır. Yöre mermerlerinin CaO oranları %52.9-55.4 arasındadır. Uşak Yeşil Mermeri diğer bölge mermerlerine göre daha yüksek oranda SiO2 (%5.06), TiO2 (%0.16) ve Fe2O3 (%1.25) içermektedir. Uşak Yeşil Mermerinin yüksek SiO2 içeriği mermerlere sert bir yapı kazandırmıştır. Opak mineraller, epidot ve mika minerallerin bileşimlerinde bulunan TiO2 ve Fe2O3 ana oksit değerlerindeki kısmi zenginleşmenin bu mermere açık yeşil renk verdiği belirlenmiştir.
KONDISI SOSIAL EKONOMI NELAYAN SUKU BAJOE DI DESA WAIWURING KECAMATAN WITIHAMA KABUPATEN FLORES TIMUR
Authors: K. L. Saburi Patrisia Yuliana , Rahmawati Arfita , Sunimbar Sunimbar
Published: October 2022

This research aims to (1) Know the socio-economic conditions of Bajoe fishermen in Waiwuring Village (2) Know the empowerment program of fishermen in obtaining business capital to improve the welfare of Bajoe fishermen in Waiwuring Village (3) Know the spatial patterns of bajoe fishing communities in Waiwuring Village. This type of research is descriptive research, which is a type of research that has the aim to explain specifically a symptom, event, that occurs at the present moment or actual problems by using data in the form of quantitative data and qualitative data. The population in the study was as many as 100 heads of families. The sample size in this study was 50 heads of families. The data source consists of primary data and secondary data. Data collection techniques are: questionnaires, interviews, observations and documentation. The data analysis techniques used are qualitative analysis and quantitative analysis. The analsisis technique of spatial patterns uses interpolation techniques. Research results: (1) socio-economic conditions of the Bajoe fishing community when viewed from net income, health, education and housing are still classified in poor or less decent communities (not yet prosperous),, (2) bajoe fishing communities still rely on their own financial capital., (3) the spatial pattern of the fishing community of the Bajoe Tribe forms a grouping pattern.
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS APLIKASI SPARKOL VIDEOSCRIBE PADA MATA PELAJARAN GEOGRAFI KELAS XI DI SMA NEGERI 5 KUPANG
Authors: Wadu Mariana Rodjo , Samin Mikael , Pamungkas Bella Theo Tomi
Published: October 2022

This study aims to (1) determine the development of learning media based on the Sparkol Videoscribe application in the geography subject of class XI at SMA Negeri 5 Kupang, (2) determine the feasibility of the learning media developed, and (3) determine the responses of teachers and students to the use of media. learning. The type of research used is Research and Development (R&D) with the ADDIE development model (analysis, design, development, implementation, and evaluation). The research subjects were 50 students in class XI, and 1 teacher for geography in class XI. Data collection techniques using questionnaires and interviews.  The results of the study were in the form of learning media based on the Sparkol VideoScribe application. The developed media met the criteria for media quality with the results of the validation of media experts in the very appropriate category, 87% and 79% by material experts in the appropriate category. Meanwhile, the teacher's response to the learning media trial was 85%, the response of 10 students to the small scale trial was 83% and the response of 40 students to the large scale trial was 84%, all of which were categorized as very feasible. So, it can be concluded that the learning media developed based on the Sparkol VideoScribe application in class XI geography subjects at SMA Negeri 5 Kupang is suitable for use in the learning process and it is recommended that teachers use Sparkol VideoScribe in designing learning media as an alternative to improve the quality of learning.
The Role of Country and Self-Determination in Revitalisation
Authors: Ringel Christina
Published: October 2022

The UNESCO Decade of Indigenous Languages (2022-2032)is a good opportunity for shining a light on language endangerment in Australia. In this paper, I argue that many causes of endangerment can be traced back to a relocation of speakers of Indigenous languages from their traditional land. A case in point is the endangered language Miriwoong. The analysis of a case study with the Miriwoong people will demonstrate that both their traditional educational practices and several current revitalisation projects rely on access to traditional Country. Miriwoong is no longer transmitted in natural contexts, i.e. it is not spoken and learned in the family home. Thus, in order to achieve the goal of countering endangerment, the community needs the support that Australian governments can provide via the mainstream education system. For such projects to be effective, self-determination needs to be part of any policies concerning formal education. This ensures that traditional beliefs and practices, such as teaching ‘on Country’, can be properly incorporated.
PRODUCTIVE FORCES: STRATEGIC FACTOR OF INNOVATIVE DEVELOPMENT OF TERRITORIES
Authors: Matveev V.V.
Published: October 2022

The article is devoted to the consideration of the actual problem of the modern Russian economy: ensuring the effective competitive development of the country's territories. It is well known that the economic growth of the national economy and its territories expresses the changes that take place in the system of productive forces. The specificity of modern economic growth is determined by the processes of development and implementation of innovations. One of the main problems of backward countries and territories is determined by the impossibility of using modern technologies due to backward productive forces. It is noted that the problem of the relationship between changes in the productive forces and territorial development has long been of interest to scientists. The first attempts to explain the factors of territorial development date back to the first half of the 19th century. Currently, the theory of "new economic geography" is very popular. Its author is Nobel Prize winner in Economics P. Krugman, who combines traditional theories of production location, spatial factors of national and territorial economic growth with issues of international trade and agglomeration processes. Unfortunately, for many reasons, the economy of modern Russia is not able to be competitive in relation to the leading countries in the use of innovations. The situation is aggravated by economic sanctions from many countries. Under these conditions, there is a great temptation to increase the influence of the state on the development of territories. However, we believe that the solution to the problems associated with ensuring the economic growth of territories based on the effective distribution of productive forces is determined by the need to mitigate and eliminate a huge number of regulatory functions of the state.
THE PROBLEM OF FIGHTING EXTREMISM IN THE CONDITIONS OF INFORMATION WAR
Authors: Ibragimova E.S.
Published: October 2022

The article contains information on the currently pressing problem of combating extremism in the context of the information war. Taking into account the introduction of digitalization, information wars have moved to a new level, propaganda is now being conducted through Internet resources, extremism has moved to a new level. One of the important problems for Russia and for the entire world community as a whole today is extremism. This is primarily due to deep economic, political, interethnic contradictions, persistent crises in the political and socio-economic spheres, systemic instability, external challenges and threats. By fomenting inter-group conflicts, extremism poses a real threat to public security and the integrity of the state. Also, problems were identified with the increasing cases of manifestations of extremism and the difficulty of controlling all information that enters the Internet, as well as the inability to predict the effectiveness of propaganda and the number of people following them. Therefore, it is extremely important for any state to take measures aimed at countering extremism. This article contains an analysis of the significance of the above problem, methods for solving it and the views of scientists on this situation.
The role of estimation of plasma von Willebrand factor concentration in stroke risk stratiﬁcation in patients with atrial ﬁbrillation
Authors: Rubanenko A. O. , Rubanenko O. A.
Published: October 2022

Introduction. Von Willebrand factor (vWF) is a large plasma glycoprotein that plays a major role in hemostasis. The vWF plasma concentration is not included in modern stoke risk stratification scales in patients with atrial fibrillation (AF).

Aim — to evaluate the possibility of usage of vWF plasma concentration in stroke risk stratification in patients with atrial fibrillation.

General findings. vWF is an important predictor of stroke development in patients with AF based on the results of the conducted meta-analysis that included 12 studies and 7449 patients with AF. Determining the concentration of vWF in patients with low risk of stroke development or in those patients with a single non-sex CHA2DS2-VASc score risk factor may be useful in deciding whether to prescribe anticoagulant therapy.
Lessons Learned From Conducting Community-Based Research on HIV Prevention With Youth During COVID-19
Authors: LeMasters Katherine , Maragh-Bass Allysha , Stoner Marie , Bhushan Nivedita , Mitchell John , Riggins Linda , Lightfoot Alexandra
Published: October 2022

Mitigating HIV burden among Black youth requires true community engagement. This brief report identifies challenges, strategies, and lessons learned from transitioning our three-phased, community-engaged HIV prevention project with Black youth to a remote format during COVID-19. The project involved (1) building a community-academic partnership on youth sexual health, (2) participatory youth workshops, and (3) youth surveys and interviews about HIV prevention. Feedback from community-academic partnership, pile sorting themes, and preliminary qualitative analyses guided this report. Challenges included a disruption to in-person engagement while strategies included relying heavily on pre-existing partnerships to recruit youth for interviews. We learned that pre-existing community engagement was essential for completing phase three remotely. More education is needed to support Pre-Exposure Prophylaxis (PrEP) awareness for HIV prevention and there is a need to address structural barriers to healthcare engagement such as community violence and mental illness. Community-engaged HIV research focused on youth can adapt if anchored in community relationships. Future studies must work to more fully center youth’s voices and address the structural issues that may inhibit them from engaging in HIV prevention.
Quantum Cryptography a Real Threat to Classical Blockchain: Requirements and Challenges
Authors: Khan Wazir Zada , Arshad Qurat-ul-Ain , Raza Mudassar , Imran Muhammad
Published: October 2022

Classical blockchain cryptographic primitives are susceptible to quantum computing technology due to its unprecedented growth because it has the potential to make current blockchain encryption techniques obsolete against quantum attacks. Shor algorithm can perform transactional hijacking and forge digital signatures to impersonate blockchain users. On the other hand, Grover algorithm can perform 51% attack and can accelerate brute force attack by detecting hash collisions to replace the blocks of a blockchain. With the advent of this threat, in attempt to mitigate the effects of quantum attacks on blockchain technology, the concept of post-quantum cryptography (PQC) or quantum resistant cryptography (QRC) has emerged. PQC involves cryptographic algorithms or cryptosystems that are robust against quantum attacks and are also applicable in blockchain for post quantum decentralization. In this article, we provide a brief overview of quantum threats to classical blockchain technology. We identify and discuss some important requirements for the implementation of PQC. Moreover, we also identify and explain notable unresolved challenges in implementing PQC algorithms. We also determine critical research questions for each identified challenge that are imperative to confer and requires discussion and interpretation by the researchers of this field. 
On the correct mathematical description of polarization dependent impairments in Optical Communications
Authors: Janer Carlos L.
Published: October 2022

 In this paper it is shown that the mathematical framework that correctly describes the combined effects of polarization mode dispersion and polarization dependent losses is the irreducible spinor representation of the extended Lorentz Group. 

There are two kinds of states of polarizations that are relevant for the description of PMD-PDL effects. The optical process that allows to convert one kind into the other is identified as optical phase conjugation. The utility of the proposed mathematical framework is proven proposing a simple technique (based on optical phase conjugation) that cancels the PDL part of the impairments at the receiving end of the optical system.
Nonlinear FDTD Simulation of Optical Thin Films with Intensity-Dependent Drude-Lorentz Parameters
Authors: Nizer Rahmeier João , Smy Tom J. , Gupta Shulabh
Published: October 2022

Nonlinear optical materials, such as transparent conductive oxides, have recently drawn a lot of attention when being integrated into metasurfaces and allowing full-optical control of the surface response. Although several methods for modeling the nonlinear materials have been proposed in the literature, most of them have the limitations on being non-dispersive and of instantaneous response. In this paper, we present a straightforward integration of an extended Drude-Lorentz model that captures the local intensity response of nonlinear materials while being dispersive and allowing for inertial response via a low-pass filtering process. This method is integrated into standard finite difference time-domain (FDTD) implementation of Maxwell’s equations and the auxiliary differential equations approach of the Drude-Lorentz model is extended via local intensity-dependent parameters. A numerical demonstration shows the response for a thin film of nonlinear material, where the parameters across the sample are time-varying with respect to the local intensity of the fields. Therefore, showing a direct feedback of the field profile to the nonlinear response of the material, which is critical when incorporating such films in resonating meta-atoms.
An Ambient RF Powered Wireless Sensor System
Authors: CHIU Ming-Tai , CHIU Chi-Yuk , NG Charles , WONG Lap-On , Shen Shanpu , Murch Ross
Published: October 2022

The development of an ambient radio frequency (RF) powered Internet of Things (IoT) wireless sensor system is reported. The system integrates all major components including multiple antennas, rectifiers, a power management unit (PMU), a microcontroller unit (MCU) with RF transceiver module and sensing unit. A novelty of this applied engineering innovation is the design and use of multi-band dual-polarized multiple antennas to handle the low ambient RF power density found in the everyday environment. Our prototype has demonstrated that it is able to sense temperature, pressure and humidity and wirelessly transmit these signals to a central server with a duty cycle of approximately 15 minutes, when the background ambient RF signals are as low as −28.6 dBm at 950 MHz. The proposed system can address the important issue of energy supply in the development of IoT providing an alternative energy source to batteries or solar cells. Ambient RF powered IoT devices do not require periodic replacement of their batteries or to be placed visible regions which makes them suitable for wall, ceiling and floor applications. Our ambient RF powered IoT wireless sensor system provides concrete proof, through demonstration, that harnessing ambient RF energy for powering IoT sensor systems is feasible.
Multi-lingual Handwriting Recovery Framework based on Convolutional Denoising Autoencoder with Attention model
Authors: Rabhi Besma , Elbaati Abdelkarim , Boubaker Houcine , Pal Umapada , Alimi Adel
Published: October 2022

For several decades, the offline handwriting recognition problem has escaped a satisfactory solution. In the field of online recognition, researchers have had more successful performance, but the ability to extract dynamic information from static images has not been well explored yet. In this paper, we introduce a novel multi-lingual word handwriting recovery framework based on a convolutional denoising autoencoder with an attention model for pen up / down, velocity and temporal order recovery. The proposed framework consists of extracting robust features from a handwriting image using a stacked denoising autoencoder and an encoder Bidirectional Gated Recurrent Unit (BGRU) model. Then, the obtained vectors are decoded to produce an online script with dynamic characteristics using a BGRU with temporal attention. Evaluation is done on a Latin and Arabic Online and offline handwriting character / word databases and the proposed framework achieves high competitive results. To the best of our knowledge, this is the first work of its kind.
Economic viability and development of radish (Raphanus sativus L.) under different soil water tensions and mulching types
Authors: Balbino dos Santos Pietros André , De Carvalho Luiz Gonsaga , Schwerz Felipe , Buono da Silva Batista Victor , Ussi Monti Cassio Augusto
Published: October 2022

There is a lack of information on the production of irrigated radish associated with the use of mulching and on the economic viability of these production technologies. The objective of this study was to evaluate the growth, yield, and economic viability of the radish crop under different soil water tensions (SWT) and mulching types. The experiment was conducted in a greenhouse. During the experiment, the following variables were evaluates: growth parameters, yield and economic viability. SWT at 7 kpa in the treatments without mulching and at 12 kPa in the treatments with black plastic and black non-woven resulted in higher growth parameters and yield. The leaf area index and the root diameter were the parameters that had a high and positive correlation with yield. Expenses with variable resources represent on average 75% of the total production cost. Therefore, the investment pays all resources applied in the activity and provides an economic profit. In this context, the higher radish yield with 37.5 t ha-1 provided the highest profitability of the evaluated treatments, thus, for radish production, the recommendation is to use 12 kPa as an indicator of the moment for irrigation, associated with the use of black plastic.
Objects of the Funerary Cult in the Han Dynasty. Gold and Silver Items. Aesthetics of Gold and Silver in the Han Dynasty
Authors: Qiu Mubing
Published: October 2022

The unification of China under the rule of the Han Dynasty and the subsequent prosperity of the state inevitably led to a sharp increase in the production of gold and silver items. The emperors of the Western Han Dynasty often rewarded officials who had served with gold to the extent that cast gold discs and gold bars were included in circulation. Looking at the gold and silver items that archaeologists find in the tombs of the Han period makes one see the superiority of utensils in this era over the items of previous periods both in quantity and in their typology, and possibly in terms of manufacturing complexity.
Having become an independent craft, separate from traditional bronze casting, it strongly influenced the art of subsequent Chinese dynasties. Gilding technologies appeared in China as early as the early Zhanguo period. This highly commendable art used in the decoration of bronze, which was densely covered with gold, reached its maturity in the pre-Qin period and gained popularity during the Han Dynasty. Most importantly, in the Han Dynasty, the fine art of decorating with silver and gold reached a new, higher level and, no longer being part of the bronze casting craft, received independent development.
Silver utensils of the Han period are found evenly throughout the territory of modern China. Silver caskets, funnel-shaped vessels and many ornaments were found in the tombs of the Jing king, Liu Sheng, in Zhongshan, the Huai king, Liu Xiu, and the Mu king, Liu Chan, in the same city district. Gold and silver vessels are evidence of the development of the art of working with gold and silver. Silver and gold vessels that archaeologists find in the graves of the highest tribal nobility of the Han Dynasty not only speak of the high level of this industry in the Han Dynasty but also testify to a unique culture and help us better understand the society of this time.
Song Dynasty Aesthetics. Origins of the New Chinese Furniture Design Style
Authors: Kazakova Natalia Yu. , Qiu Qi
Published: October 2022

Summary： In the article, the authors analyse the primary problems which arose during the design product development in the field of industrial furniture production during the period from the beginning of the 20th century, including during the opening of China, to the present. The vector of the furniture industry development is studied through the industrial design evolution. The reasons for the emergence of a new style in furniture design in China, analysed in detail in connection with changes in economic and cultural realities, are studied.
The question of the influence of the Song dynasty aesthetics on the formation and development of a "new language" in furniture design is touched upon.
This dynasty’s cultural heritage formed the basis of the new style in design not only in terms of appearance, shape and structure but also in a deeper understanding of the principles of constructing form and meaning inherent in traditional Chinese culture. As an important part of the ancient culture of China, the Song Dynasty aesthetics is an invaluable spiritual national heritage of the entire nation, which is fully reflected in the revival of mass interest in national culture in the field of technical aesthetics and industrial production.
Compared to Russia, the modern model of design development is completely different. Design in Russia largely follows the development vector laid down within the framework of the Soviet Union's “technical aesthetics” and still largely meets the needs of the industry (of course, with the necessary adjustment for time). In Russian history, the formation of the profession of a designer coincided with two revolutions: a political revolution that led to a change in social attitudes, and an artistic revolution that began before the first and continued after it, while Chinese modern design did not seem to have experienced such significant perturbations. However, it seems that the concept of the New style of design in China and the concept of Russian modern design, based on the experience of the Soviet period, rely on traditions, actively incorporate innovations and strive to find a unique path that best suits the development vector of each of the countries.
Autism Spectrum Disorder Comorbid with Gilles De La Tourette Syndrome in a Child of in Vitro Fertilization: About A Case and A Review of the Literature
Authors: Berrada H. , Chebli H. , Kisra H.
Published: October 2022

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by persistent impairment in reciprocal communication and social interactions and a restricted repetitive pattern of behaviors, interests, or activities. Tourette syndrome (TS) is a neurological disorder with a genetic component characterized by involuntary, sudden, brief and intermittent tics, resulting in movements (motor tics) or vocalizations (sound tics). Although a differential diagnosis of the two conditions can often be made, there are also cases of comorbidity in the same patient. Recently, a number of studies have attempted to explore modifiable environmental risk factors for ASD and TS. Among these risk factors is in vitro fertilization, an assisted reproduction technique, which has become increasingly common. The aim of our work is to highlight via a clinical case and a review of the literature on the association between the use of in vitro fertilization, the risk of autism spectrum disorder and Tourette syndrome. Compared to spontaneous conception, in vitro fertilization treatment as a whole was associated with a small but statistically significantly increased risk of autism spectrum disorder and Tourette syndrome.
Mondor's Disease Superficial Thrombophlebitis of the Chest Wall: Case Report of a Rare Condition
Authors: Apolo Paul Aldaz , Tapia Gonzalo Pullas , López Karina López , Bermeo Julián Acosta , Morocho Angie Loaiza , Yanez Carina Contreras , Cabrera Kattya Cordova , Valladares Lizeth Guamba
Published: October 2022

Introduction: Superficial thrombophlebitis of the chest wall is referred to as Mondor's disease (MD). Other atypical locations such as abdominal, inguinal and penile regions have been described in the literature [1]. In the thoracic region, the veins mainly affected are the thoracoepigastric vein and the superior epigastric vein. Its incidence is low and it generally occurs in the middle-aged people [2]. It is a benign, self-limited lesion whose treatment is usually conservative. The resolution of the clinical picture in most cases occurs within 4 to 8 weeks [2, 5]. Clinical Case: A 41- year-old female patient, no personal pathologic history. She went to the doctor for medical consultation due to the presence of a lump in the right submammary region after thoracic trauma with a car seat belt in a traffic accident of 12 days of evolution. She reported pain and progressive increase of the lump size. Physical examination revealed the presence of a venous lump in the right chest and abdominal wall, 1 cm in diameter, solid, painful on palpation, extending from the right submammary region to the right side with a length of 13 cm. Based on the clinical and ultrasound study, a diagnosis of Mondor's disease was made. An initial conservative management was decided with the use of anti- inflammatory drugs, analgesics and clinical and ultrasound monitoring at 4 weeks. Conclusion: Mondor's disease is a clinical disease of infrequent occurrence; its diagnosis is based mainly on a detailed clinical history and can be complemented with color Doppler ultrasound. Being a self-limited disease, the treatment with the highest success rates is conservative, reserving surgery in cases of difficult pain treatment.
The Chemistry Effects of Garlic on Hormones in Male Rabbits
Authors: Aldeeb Osama H. , Allafi Eman G. A. , Bohtera Nosiba E. , Khaled Fayrouz A.
Published: October 2022

Abstract: Garlic contains more than 200 chemicals. It contains sulfur compounds (allicin, alliin and agoene), unstable oils, proteins (allinase, peroxidase and miracynase), carbohydrates (sucrose and glucose), and minerals (selenium). It too contains amino acids (cysteine, glutamine, isoleucine and methionine), which offer assistance to ensure cells from the hurts of free radicals, bioflavonoids (quercetin and cyanidin, allistatin I and allistatin II and vitamins C, E and A), which offer assistance to secure us from oxidation operators and free radicals. Comes about demonstrated that treatment with garlic caused critical (P<0.05) increment in body weight (BW) and relative weight of, brine, testicles, testosterone, T3 and T4. Whereas, diminish the levels of FSH, LH, estradiol and progesterone in plasma compared to control creatures.
Contribution of the Diode Laser in Implantology
Authors: S Hajjaji , Esghir A. , Hajjami H. , Boughzella A.
Published: October 2022

Abstract: For the past fifteen years, lasers have been used successfully in dentistry. Each laser is specific by its wavelength. The absorption of laser radiation in hard or soft tissues depends on this wavelength. Laser-assisted dental surgery techniques have become recognized and must be part of our therapeutic arsenal. Their integration in implantology opens new possibilities. Among the lasers used in implantology is the diode laser which has interesting characteristics in the fields of decontamination and bio-stimulation, but can also be used for its ablative action on soft tissues. However, the success of an assisted laser treatment remains conditioned by the adequacy between the clinical case, the establishment of a good indication and the choice of the adapted laser material, which implies and requires a good knowledge by the practitioner of the respective modes of action of the laser, its main indications and its therapeutic limits.
Oral Health Benefits of Phyllanthus Emblica
Authors: Mirajkar Dr. Chaitali , Hambire Dr. Umesh
Published: October 2022

Abstract: Phyllanthus emblica also known as Emblica officinalis belongs to the Euphorbiaceae family. It is also known as Indian gooseberry, emblic myrobalans, and Amla (in Hindi). It has anti-inflammatory, antioxidant, cryoprotective, antiaging, antidiabetic and hepatoprotective properties. The fruit of Amla is rich in vitamin C (ascorbic acid) and contains several bioactive phytochemicals. It also contains polyphenols such as ellagic acid, chebulinic acid, gallic acid, chebulagic acid, apeigenin, quercetin, corilagin, leutolin. It has antimicrobial and anti-ulcerative property. It is used for management of oral ulcers and periodontal diseases.
Statistical Significance was observed for the Responses between the Participants about Knowledge, Attitude and Practice toward the Effect of Diabetes on Oral Health among adults living with diabetes in Makkah City
Authors: Alhajaji Raghad
Published: October 2022

Abstract: Background: Diabetes mellitus is one of the most common metabolic diseases. In addition to its several effects on general health, it also has a specific effect on oral health. Methods: This comparative cross-sectional study design was conducted at governmental primary health care centers in Makkah, Kingdom of Saudi Arabia. The sample size was 222 of adults living with diabetes. The data was collected by a structured survey that included close-ended questions. The data was entered and analyzed by using multiple software programs. Results: A total of 222 Diabetic patients 112 males (50.5%) of them and 110 females (49.5%), consisting of 176 (79.3%) Type 2 Diabetes and 30 (13.3%) Type 1 while there are 14(6.3%) patients did not know their diagnosis of type of diabetes. A response rate of 100% was observed, 79.7% reported that have knowledge about the effect of DM on general health while only 43.2% reported that have Knowledge about the effect of DM on oral health. 88.7% of total diabetic patients regularly Brush their teeth, on the other hand, only 33.3% reported that they do regular flossing. 84.2% of participants know the importance of routine dental visits. However, 14.9% of them go for a regular checkup while 82.2% visiting their dentist only when having dental problems. Conclusions: Diabetic patients need properly designed oral health education and screening programs to increase their knowledge and attitude toward oral health and prevent diabetic complications on oral health.