bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnostic difficulties of small intestinal neuroendocrine tumors: clinical case
Authors: Kotelnikova L. P. , Shatrova N. A. , Trukhacheva E. A.
Published: November 2022

The objective of the study was to demonstrate the difficulties of diagnosing the neuroendocrine tumor (NET) of the small intestine at the example of a concrete clinical case. In the case presented, clinical manifestations of the disease were nonspecific and the examination began from a low-informative method multispiral computed tomography (MSCT) without a bolus contrast study that was the reason of wrong diagnosis for 7 months. The detection of the swollen lymph node in the mesentery was interpreted incorrectly; additionally, only endoscopic investigation of the stomach and large intestine was used. By means of MSCT-angiography we succeeded to diagnose not only the lymph node conglomerate in the mesentery, but to reveal a tumor sized 915 cm in the ileac wall. Laparoscopy with lymph node biopsy after its morphological study permitted to verify the diagnosis before the surgery.

To reduce the period of diagnostics of small intestinal NET, general practitioners should be informed on specific features of clinical manifestations of the disease and rational diagnostic methods. MSCT-angiography showed its efficiency in detection of small-sized small intestinal NET, and laparoscopy with biopsy of the mesentery lymph node will permit to verify the diagnosis before surgery.
Dissection of the VI cervical lymph collector for papillary thyroid cancer
Authors: Aleksandrov Yu. K. , Dyakiv A. D.
Published: November 2022

Objective. To assess the expediency and necessity of implementing the dissection of the central cervical lymph nodes (group VI) in patients with papillary thyroid cancer.

Materials and methods. The results of preoperative examination, surgical treatment and its follow-up were evaluated in 210 patients, who along with thyreoidectomy, underwent dissection of the central cervical lymph nodes (group VI).

Results. It was established that for papillary thyroid cancer, a high frequency of cervical lymph node metastasis is typical. During the preoperative examination, (US and cytological study), metastases were detected in 23.5 % of patients, and while pathomorphological study of the removed central neck cellular tissue in 47.4 % more. Therefore, preventive dissection of the central cervical lymph nodes (VI group) is worthwhile.

Though expansion of the volume of operations in patients with papillary thyroid cancer at the expense of dissecting the central cervical lymph nodes in addition to the thyroid gland, leads to insignificant elevation of the number of complications but in the remote period (35 years), volume expansion of operations has no negative impact on the indicators of physical and psychical components of the life quality.

Conclusions. The obtained objective information regarding the presence or absence of metastatic lesion of the cervical lymph nodes permits to ground the process staging in papillary thyroid cancer and form treatment tactics.
Laser-induced thermotherapy of thyroid nodules with ablation of vessels feeding the nodule
Authors: Petrov V. G. , Sozonov A. I. , Baksheev E. G. , Ivashina E. G. , Ermakova A. A. , Ermakova P. A.
Published: November 2022

Objective. To improve the results of treatment in patients with benign nodular pathology of the thyroid gland (TG) by means of perfecting the technique of minimally invasive treatment with a high-intensive laser under the sonographic control.

Materials and methods. An original technique of laser-induces thermotherapy (LITT) of the thyroid nodule with the ablation of the vessels, feeding the nodule was developed and introduced. The procedure was used in the treatment of 91 patients with benign nodular pathology of the thyroid gland, 116 patients underwent laser-induced thermotherapy by the standard technique (comparison group). Three months later, US was used to assess and compare the results of treatment in both groups. The results of thermometry were analyzed depending on the initial volume of the TG nodular neoplasm.

Results. A decrease in the nodules with the initial volume up to 2 cm3 in both groups was statistically significant and took place practically similarly 78.7 % in the main group and 71.7 % in the comparison group. When exposing the nodules of larger sizes, the efficiency of standard LITT method fell. In the comparison group, patients with the nodular sizes of 68 cm2 had a decrease in the volume only by 25.8 % % (from 6.74 cm3 to 5.0 cm3). When using an original method of thermoablation (TA), a decrease in the nodules of the same size was 69.3 % (from 6.98 cm3 to 2.14 cm3). The difference was statistically significant (p = 0,003) that proves the efficiency of this technique. In the subgroup with the nodules 8 cm3, a nodular volume decrease was 33.3 % (from 11.05 to 7.36 cm3) in the main group and 28.8 % (from 14.07 to 10.02 cm3) in the comparison group. The difference was not statistically significant (p = 279).

Conclusions. Laser-induces thermotherapy of the thyroid gland with the ablation of the vessel, feeding the nodule, leads to a statistically significant reduction of the benign colloid nodular neoplasms of any size. The original technique indicated higher efficiency compared with standard LITT in relation to the nodules sized from 6 to 8 cm.
Research Project "Media as a Language Enviroment for Native Speakers of the Sami Language": Experience of Development and Implementation
Authors: Бакула В.Б. , Коренева А.В. , Рычкова Т.А.
Published: November 2022

Представлен исследовательский проект «Медиа как языковая среда для носителей саамского языка», реализованный преподавателями кафедры филологии и медиакоммуникаций Мурманского арктического государственного университета. Раскрываются цель, задачи и основные направления проекта, ориентированного на поддержку и популяризацию языка саами – одного из коренных народов Арктики. Описываются содержание и результаты устного опроса саамов, в ходе которого было уточнено количество носителей саамского языка, определен уровень его востребованности носителями в повседневной жизни, охарактеризовано его место в системе ценностей респондентов. Выявлена степень поддержки в изучении языка со стороны саамской общественности и языкового сообщества. Сделан вывод о целесообразности создания языковой медиасреды для ревитализации саамского языка.

The research project «Media as a language environment for native speakers of the Sami language», implemented by teachers of the Department of Philology and Media Communications of the Murmansk Arctic State University, is presented. The purpose, objectives and main directions of the project, focused on supporting and popularizing the Saami language, one of the indigenous peoples of the Arctic, are revealed. The content and results of an oral survey of the Saami are described, during which the number of speakers of the Saami language was specifi ed, the level of demand for it by speakers in everyday life was determined, and its place in the system of values of the respondents was characterized. The degree of support in learning the language from the Sami public and the language community was revealed. The conclusion is made about the expediency of creating a language media environment for the revitalization of the Sami language.
Synergetic and Heutagogical Approaches, Connectivism and Humanistic Psychology in Modern Postgraduate Education and Personality Development
Authors: Мынбаева А.К.
Published: November 2022

В статье актуализируется проблема разработки современных основ педагогики и психологии послевузовского образования, направленных на развитие личности в течение жизни. Рассмотрены положения синергетики и эвтагогики, коннективизма и гуманистической психологии, включенные в образовательный курс «Синергетика и эвтагогика для саморазвития личности». Представлены подходы к обучению, включающие теорию и практические инструменты саморазвития личности: коучинговые технологии, сторителлинг, проективные методы.

The article actualizes the problem of developing modern foundations of pedagogy and psychology of postgraduate education aimed at the development of personality during life. The provisions of synergetics and heutagogics, connectivism and humanistic psychology included in the educational course “Synergetics and eutagogics for personal self-development” are considered. The approaches to training are presented, including theory and practical tools for personal self-development: coaching technologies, storytelling, projective methods.
Co-Study of Native and Studied Cultures as а Condition for the Formation of lntercultural Competence of Foreign Students
Authors: Анопочкина Р.Х.
Published: November 2022

Описывается опыт формирования межкультурной компетенции в процессе обучения русскому языку как иностранному. Обосновывается необходимость применения взаимосвязанного изучения новой и родной для студентов культур, формирования позитивного восприятия культурных различий с представителями других народов, постоянного развития студентами собственных коммуникативных качеств. Делается вывод о том, что восприятие родной культуры студентов в качестве условия изучения новых культур явилось закономерным результатом развития лингводидактики. Рассмотрены некоторые проблемы и пути соизучения культур на занятиях русского языка как иностранного, приведены примеры из практики автора.

The experience of forming intercultural competence in the process of teaching Russian as a foreign language is described. The necessity of applying the interconnected study of new and native cultures for students, the formation of a positive perception of cultural diff erences with representatives of other peoples, the constant development of students’ own communicative qualities is substantiated. It is concluded that the perception of students’ native culture as a condition for studying new cultures was a natural result of the development of linguodidactics. Some problems and ways of co-studying cultures in the classroom of Russian as a foreign language are considered, examples from the author’s practice are given.
Accelerating standing electromagnitic waves withing EmDrive engine cavities
Authors: Зубков В.И.
Published: November 2022

Рассмотрены ускоряющиеся стоячие электромагнитные волны, представляющие собой суперпозицию движущихся навстречу друг другу ускоряющихся и замедляющихся волн одной частоты. Приведены примеры ускоряющихся стоячих электромагнитных волн, показано, что они идеально объясняют появление силы тяги в двигателях EmDrive. Рассмотрено создание силы тяги ускоряющейся стоячей волной в резонаторе с дисперсией. Исправлена ошибка в вычислениях силы тяги двигателя EmDrive, допущенная в одной из предыдущих работ. Показаны сходство и различия двигателя EmDrive и реактивного двигателя.

Accelerating standing waves representing the sum of oppositely travelling accelerating and decelerating electromagnetic waves of same frequency are considered. Examples of accelerating standing electromagnetic waves within optical and microwave cavities are presented. It is shown that accelerating standing electromagnetic waves ideally explain EmDrive engine working principle. Trust creation by accelerating standing electromagnetic wave within cavity with dispersion is considered. Mistake in EmDrive thrust calculation made in one of the previous paper is corrected. The similarities and differences between EmDrive engine and the jet engine are displayed.
Software implementation of fuzzy-multiple models for a comprehensive assessment of the dynamics of the financial and economic state of the industry
Authors: Арапова Е.А. , Крамаров С.О. , Усатый Р.С. , Рутта Н.А. , Сахарова Л.В.
Published: November 2022

Целью данного исследования является проектирование и программная реализация нечетко-множественных алгоритмов комплексной оценки финансово-экономического состояния предприятий на основе группы показателей «прибыль», «налоговые выплаты», «страхование». Для реализации программы финансово-экономического анализа отрасли использована трехуровневая иерархическая модель, преимущество которой состоит в обособленности и независимости каждого уровня. Высокоуровневое проектирование архитектуры системы выполняется на основе унифицированного языка моделирования UML (unifed modeling language). Практическая новизна созданного программного обеспечения состоит в создании интерфейса для импорта исходных аналитических данных, полученных в результате скейпинга открытых интернет-источников (testfirm, audit-it); формировании комплексных нечетко-множественных оценок в разрезе групп предприятий по отдельным показателям, динамики развития отдельных групп предприятий и отрасли в целом. С использованием разработанного программного комплекса выполнена комплексная оценка динамики развития IT-отрасли Ростовской области на основе группы показателей «прибыль», «налоги», «социальное страхование».

The purpose of this study is the design and software implementation of fuzzy-multiple algorithms for a comprehensive assessment of the financial and economic state of enterprises based on a group of indicators: “profit”, “tax payments”, “insurance”. To implement the program of financial and economic analysis of the industry, a three-level hierarchical model was used, the advantage of which is the isolation and independence of each level. High-level system architecture design is based on the unified modeling language UML (unified modeling language). The practical novelty of the created software is to create an interface for importing initial analytical data obtained as a result of scaling open Internet sources (testfirm, audit-it); the formation of complex fuzzy-multiple assessments in the context of groups of enterprises for individual indicators, the dynamics of development of individual groups of enterprises and the industry as a whole. Using the developed software package, a comprehensive assessment of the dynamics of the development of the IT industry in the Rostov region was carried out based on the group of indicators: “profit, “taxes”, “social insurance”.
Simulation of the process of aiming guided aerial missiles their targeting to a group air target
Authors: Аюш К.Х. , Баланян С.Т. , Верницкий Е.В. , Пригарин В.Н. , Судариков Г.И.
Published: November 2022

Представлена модель движения группы воздушных целей и группы управляемых авиационных ракет класса «воздух – воздух». Рассмотрен пример определения приоритетности цели среди множества других. При решении задачи группового управления авиационными ракетами класса «воздух – воздух» описан способ ранжирования воздушных целей. Факт поражения цели сравнивается по дальности с применяемой в настоящее время методикой и по многофакторной опасности – с разработанной методикой.

The article presents a model of the movement of a group of air targets and a group of guided airto-air missiles. An example of determining the priority of a goal among many others is considered. When solving the problem of group control of air-to-air missiles, a method for ranging air targets is described. The defeat of the target was compared by multifactorial danger and by range.
In-silico ADME prediction and molecular docking study of novel benzimidazole-1,3,4-oxadiazole derivatives as CYP51 inhibitors for antimicrobial activity
Authors: Kolageri Shivanand , S Hemanth , Parit Mahesh
Published: November 2022

A class of innovative benzimidazole-1,3,4-Oxadiazole derivatives is a significant heterocyclic molecule for therapeutic development. In heterocyclic chemistry, the novel 1,3,4-Oxadiazole nucleus has a wide range of uses, including antibacterial, treatment. Molecular docking is frequently employed in contemporary drug design to comprehend drug-receptor interaction. Swiss dock, PyRx, and discovery studio visualizer (DSV) tools were used to predict in-silico ADME properties. In the current investigation, substituted benzimidazole-1,3,4-Oxadiazole derivatives were taken for docking studies against 6AYB an Naegleria fowleri CYP51-ketoconazole complex. The main objective of the study is to perform docking of the selected benzimidazole-1,3,4-oxadiazole derivatives on the protein and compare the docking score with standard ketoconazole. The molecular docking study was conducted using PyRx and the discovery studio visualizer (DSV) program, Naegleria fowleri CYP51-ketoconazole complex (6AYB) was obtained from the protein data bank (PDB) site. It was found that the docking score of all sixteen 1,3,4-Oxadiazole compounds ranged from -8.1 to -8.9 Kcal/mol. The novel benzimidazole with 1,3,4-Oxadiazole derivatives has been found to possess antibacterial properties, many substituted 1,3,4-Oxadiazole derivatives have been reported for the activity
A brief overview of sustained released drug delivery system
Authors: Prajapat Priyanka , Agrawal Dilip , Bhaduka Gaurav
Published: November 2022

The most popular and patient-friendly method of drug administration is often thought to be the oral route of administration. Compared to conventional release formulations, advancements in formulation technology, including modified release dosage forms or sustained release oral dosage forms, have been extensively accepted. A sustained release dosage form provides a prolonged release of the drug over an extended period, thereby giving better patient compliance and enhanced bioavailability. Sustain release systems are considered a wiser approach for drugs with short half-lives requiring repeated dosing. Sustained release drug delivery has a range of advantages over conventional dosage forms, including increased patient compliance due to less frequent drug administration, significantly reduced steady state drug level fluctuations, maximum drug utilization, the increased safety margin of potent drugs, lower healthcare costs due to improved therapy, and shorter treatment times. The present review focuses on design, fabrication, and various factors that influence the performance of sustained-release dosage forms.
Caja de herramientas para resiliencia climática: las asociaciones público-privadas de transporte en Colombia
Authors:   Rebel
Published: November 2022

Colombia debe migrar hacia un crecimiento económico sostenible a largo plazo, en el cual se prioricen los proyectos social, ambiental, institucional y financieramente sostenibles. Este crecimiento requerirá profundizar la inversión privada, además del acceso a nuevas fuentes de financiamiento, dado los limitados espacios fiscales. Afortunadamente, Colombia ha coordinado esfuerzos para ajustar su modelo de concesiones mediante la reciente elaboración y publicación del CONPES 4060, denominado Política para el Desarrollo de Proyectos de Infraestructura de Transporte Sostenible: Quinta Generación de Concesiones Bajo El Esquema de Asociación Pública Privada Concesiones del Bicentenario. El CONPES 4060 busca mejorar los activos y servicios de infraestructura en materia de sostenibilidad, enfrentar los problemas identificados, y profundizar su aporte a la economía y el bienestar del país desde la infraestructura de transporte. Así mismo, incorpora las cuatro dimensiones de sostenibilidad (social, ambiental, económico-financiero e institucional), permitiendo a Colombia a obtener una visión integral a largo plazo y apoyando la recuperación económica sostenible tras la crisis del COVID-19.
Исследование графеновых аэрогелей в качестве пористой углеродной матрицы для литий-серных батарей
Authors: Султанов Ф. , Жайсанова А. , Ментбаева А. , Джакупова Ж.
Published: November 2022

Литий-серные батареи являются системами хранения энергии нового поколения ввиду высокой теоретической емкости (1675 мАч/г), удельной энергоемкости (2600 Вт·ч·кг-1) и безопасности эксплуатирования. Более того, данный тип батарей привлекателен ввиду замены дорогостоящих катодных материалов на основе металлов (никель, кобальт) дешевой и доступной серой. Однако промышленное применение литий-серных батарей ограничено низкой электропроводимостью серы, растворением ее продуктов в электролите и объемным расширением при циклированном заряде-разряде батарей ввиду высокой разности плотностей серы и ее продуктов (полисульфиды лития). В работе показана возможность применения графеновых аэрогелей (ГА) в качестве пористой электропроводящей матрицы для иммобилизации серы с целью формирования катодов для литий-серных батарей. Разработанный катодный материал на основе графенового аэрогеля и серы показал высокое значение начальной разрядной емкости (1313 мАч/г) с ее средним снижением на 0,5% за 1 один цикл при 75 циклах заряд-разряда (0,1С). Полученные результаты показали, что графеновые аэрогели являются перспективными материалами для иммобилизации серы ввиду их высокой пористости, легковесности и электропроводимости.
Obtaining small-sized heat-energy briquette of carbon-free flame
Authors: Zhumakhan K. , Tileuberdi E. , Biysenbayev M.A. , Toktarbay Z. , Abutalip M.
Published: November 2022

The article aims to develop a technology for producing a modern fuel briquette from rice husks (RH), which can be used in a complex, gives little flame, and does not emit toxic substances during combustion. The possibility of using such briquettes is used for heating and cooking on the street and unequipped places. Consumers of briquettes can be military units in combat operations or exercises, expeditions, and tourists working in areas where a stable fuel supply is complex. To this end, oxygen-rich components are adsorbed during thermal decomposition, using the sorption properties of activated carbon associated with an increase in its specific surface area, specific volume, and pores, including a solution of oxidants in an aqueous medium, which significantly increases the combustion rate of carbon-containin g composite fuel.
Structural-Group Composition and Biological Activity of Humic and Lipid Substances of Brown Coals
Authors: Zherebtsov S.I. , Shpakodraev K.M. , Votolin K.S. , Malyshenko N.V. , Ismagilov Z.R.
Published: November 2022

The samples of brown coal, bitumen and humic acids (HA) extracted from them are characterized by means of elemental and proximate analyses, FTIR, 13С NMR (CPMAS) spectroscopy and gas chromatography-mass spectrometry. The presence of biologically active substances is detected in the extracted bitumen samples. The biological activity of humic preparations in the form of sodium humates and the saponifiable component of the extracted bituminous resin is investigated depending on the structural-group parameters: aromaticity degree (far), the hydrophilic-hydrophobic parameter (fhh), and the parameter depicting the relationship between the aromatic and aliphatic fragments of the organic mass of HA (far/al). It is shown that O-alkylation of the organic mass of coal, followed by debituminizing, changes the structural-group composition of humic acids, causes an increase in the degree of aromaticity and leads to enhancement of the biological activity of HA.
Pyrolysis of High Volatile C Bituminous Coal under the Action of Nanosecond Laser Radiation
Authors: Kraft Ya.V. , Aduev A.B. , Nelyubina N.V. , Volkov V.D. , Ismagilov Z.R.
Published: November 2022

The effect of pulsed nanosecond laser radiation (wavelength 532 nm, pulse duration 14 ns, pulse repetition frequency 6 Hz, the density of laser radiation power 0.2–0.6 J/cm2) on the tableted samples of high volatile C bituminous coal in argon medium is investigated. Among the gaseous products of pyrolysis, H2, CH4, C2H2, CO and CO2 are detected. The volume fractions of gaseous products from sample pyrolysis depending on the laser radiation power density is established. Within the laser radiation power density range 0.2–0.4 J/cm2, the volume of the formed combustible gases per unit mass of the reacted sample increases, and remains almost unchanged with further increase in power density. The volume fraction of combustible gases in the mixture of gaseous pyrolysis products are only slightly dependent on the laser radiation power density. The action of nanosecond laser radiation with a power density of more than 0.4 J/cm2 causes intense ablation of the tableted sample containing 0.005 wt.%. polyvinyl alcohol. A tableted sample containing no binding material is destroyed under the action of nanosecond laser radiation with a power density of more than 0.2 J/cm2.
Implementing a community garden in a socially vulnerable urban area of Brazil
Authors: Feyh Michele Hartmann
Published: November 2022

Community urban gardens are a type of urban agriculture. They provide spaces for social interaction and increase in life quality of maintainers and consumers. This study implements a community garden in Vila Buritis II, Planaltina, Brasília, Federal District, Brazil. The population of Planaltina has low purchasing power and high indices of social vulnerability. The implementation of the vegetable garden resulted from a partnership between agroecology students from the Federal Institute of Brasília, the local community, and the government. The work relied on donations, reuse of materials, and volunteer labor. Educational actions in the neighborhood approached the relationship between production in the garden and food choices, with a focus on healthy eating, consumption of fresh food, and reduction of industrialized items. The building of the vegetable garden converted an idle area, with a history of accumulating garbage and rubble, into a productive space for social coexistence and leisure. Twenty-seven edible species and an undefined number of ornamental plants were planted. Between 30 and 40 residents visit the space regularly and collect food for their daily meals. However, the maintenance and increase of garden productivity still need technical assistance and resources.
Az általánosított bizalom kérdőíves mérésének egyes megbízhatósági és érvényességi kérdései a magyarországi adatfelvételek tükrében
Authors: Bodor Ákos , Hegedüs Márk
Published: November 2022

Trust is a field of research in social sciences that has complex, well-developed theoreticalapproaches, but its empirical tools are less precisely grounded. The most common survey toolfor measuring generalized trust is a formula often referred to in the literature as “standard”trust question, which reads as follows: “Generally speaking, would you say that most people canbe trusted or that you need to be very careful in dealing with people?” The aim of the paper is toexamine this standard survey item along the dimensions of reliability and validity. In our analysis,we use Hungarian data obtained from various international surveys. Our results indicate seriousvalidity problems, as the standard question shows only weak linkage with additional variables,which, based on the conceptual background, should be in a close relationship with trust.KEYWORDS: trust, generalized trust, survey methods, reliability, validity
The Civis and the In-migrants
Authors: Mazsu Janos
Published: November 2022

Scholars engaged in research into the history of Debrecen have long been eager to get ananswer – beyond their specific research inquiries – to the question whether the development ofthe city had had unique features and if they had what would hallmark the unique character ofdevelopment? Was there or is there a kind of “Debrecenness”?My study examines – with the help of a GIS relational database (DTTTA1870) – whatpeculiarities can be grasped in the transformation of the traditional spatial and social structureof Debrecen enforced by the political change and industrial modernization processes twodecades after the change of feudal regime (1848/49).The analysis focuses on whether the alteration process of the factors determining the socialstatus (residential segregation, neighborhood, spatial segregation and coexistence, other spatialand social hierarchical characteristics) in the cases of the “deep-rooted Debrecen residents”(cívis) and of the settlers showed specific types described in the literature or showed specificfeatures.
A 2011-es választási reform kihatása az országgyűlési választásokra II.
Authors: Nagy Levente
Published: November 2022

A radical electoral reform took place in Hungray in 2011, as a consequence of the sweepingvictory of the Fidesz-KDNP coalition in 2010. The government initiated and implimenteda reform which was not based on a consensus of all political parties. Taking advantage of itspolitical position (qualified majority government), Fidesz introduced among other changes thewiner compensation, and gave voting right to non-resident Hungarians. The present paper triesto present some of the value-based and interest-oreinted arguments related to the reform of2011, showing that the real (power) interests were hushed up, while the government tried tolegitimize the electoral reform based on several value-oriented arguments.
Tax Reform of Corporate Income Tax on State Level in the USA
Authors:   Governors State University, Ermasova N. B.
Published: November 2022

Introduction. In proposing reforms for the corporate income taxation, it is necessary to consider the incentives generated by the current system of taxation and the effects that changing those incentives would have the significant impact on the economic behavior. Analysis. This paper proves that economic development policies and reform of income corporate taxation can significantly affects the growth of a state area, that increases in the growth of a local economy can benefits the overall national economy. Corporate income taxation can hinder the competitiveness of domestic industry by discouraging local investment in favor of investment in areas where corporate income tax rates are lower or where the tax is not levied. There are the examples of tax reforms of corporate income tax in States of Kansas, North Caroline, Michigan. Conclusion. This paper shows that R&D tax credits and State Business Tax Incentive Programs have significant and positive impacts on the growth of high-technology sector in the states.
Prospects of Venture Investment Development in Russia
Authors:   Saratov State Technical University named after Gagarin Yu. A., Plotnikov A. N. , Volkova M. V. ,   Saratov State Technical University named after Gagarin Yu. A.
Published: November 2022

Introduction. At the Russian economy’s transition to innovative development, the question of its investment mechanism is very important. Venture investment is most promising in this case. For Russia, venture investment is a rather new tool and, therefore, market mechanisms are introduced with great difficulties. Tasks and methods. To observe the current situation and the causes thereof; to detect the existence of a link between innovative development and the usage of the venture investment mechanism. Theoretical methods (analysis, synthesis, modeling, logical and system approaches, deduction, and induction) and empirical methods (observation, measurement, and comparison) were used. Results: the causes of the slow introduction of venture investment into the Russian economy were recognized; an idea of strengthening the links between innovative development and market investment mechanisms was developed. In particular, a conclusion was made that using venture investment would allow implementing developer projects as well as innovative ones. Such investments would allow companies to develop much quicker. It has impact on the regional and national development, on the increase of well-being, and on the unemployment rate decrease. Conclusion. Thus, the use of venture funds would allow turning to the innovative model of development, but the state support is necessary at the early stages of venture financing. For increasing the Russian economy’s competitiveness at this stage, it is recommended to address venture investments to a limited number of critical technologies.
Trends of the Normative Support in the Functioning of a Firm in Russia
Authors:   Balashov Post office of UFPS of the Saratov region – Federal State Unitary Enterprise Russian Post Branch, Kiselev V. K.
Published: November 2022

Purpose. Regulatory support of the company is part of the institutional support and is a complex functional process consisting of both internal and external, as well as formal and informal characteristics that reflect the accepted parameters of the existence of firms in a particular stage of development of the country. This article discusses historical tendencies, theoretical and methodological issues of development and transformation of the normative support of domestic firms. Theoretical analysis. The basis of the theoretical analysis supports is the open nature of the domestic economy and law and their interdependent development. The following main stage and characteristics of the development of regulatory support firms in Russia are highlighted: early capitalist, Soviet, post-Soviet, «unbridled capitalism» and modern. Empirical analysis. There is historically conditioned priority of politics over economics in Russia. There is a relation of trends of the normative support functioning of domestic-owned firms with the dynamics of target political reference points and prevailing form of ownership. Conclusions. There is a contradiction of «double standards» of regulatory support firm: the simultaneous creation and elimination of the corruption. The modern trend will be determined more and more by upward dynamic of influence of the state, legal institutions, standards of ethics and morality for business development in regions and «de-offshorising» in Russia as a whole.
HEMOCULTURAS PUBLICADAS NO BRASIL NO PERÍODO 2012-2019
Authors: Danielski Lucineia Gainski
Published: November 2022

Hemoculturas são exames amplamente utilizados em pacientes que apresentam sinais e sintomas sugestivos de bacteremia e sepse. Laboratórios de grande porte realizam este exame de forma automatizada, todavia laboratório de pequeno e médio porte não dispõe destes equipamentos. Desta forma as hemoculturas são realizadas de forma manual, procedimento mais demorado e sujeito a contaminações caso o manuseio seja inadequado. No Brasil, ainda não existe um trabalho que trace um perfil das hemoculturas realizadas e que foram publicadas em forma de artigo científico. Sendo assim, é importante traçar o perfil das hemoculturas publicadas pelo Brasil nos últimos 5 anos. Foram avaliados 6 artigos publicados com dados brasileiros no período entre 2012 e 2017. Os resultados mostram que a maioria das hemoculturas realizadas e publicadas por pesquisadores do Brasil foram realizadas utilizando-se métodos automatizados. Ainda encontramos um baixo número de publicações, principalmente quando relacionadas a realização de hemoculturas por métodos manuais. Dentre os principais microrganismos identificados encontram-se as enterobacterias.
A IMPORTÂNCIA DO ENFERMEIRO OBSTETRA NO ACOLHIMENTO EM UM HOSPITAL REFERÊNCIA DE ALTO RISCO EM OBSTETRICIA NO SUL DO ESTADO DE SANTA CATARINA
Authors: Miguel Taise Capaverde , Soratto Maria Tereza
Published: November 2022

Estudo com objetivo de conhecer a importância do enfermeiro obstetra no acolhimento em um hospital referência de alto risco em obstetrícia no sul do estado de Santa Catarina. Pesquisa de abordagem qualitativa, descritiva, exploratória e de campo. Aplicou-se entrevista semiestruturada com 04 enfermeiros atuantes no acolhimento e classificação de risco obstétrico. A análise dos dados foi realizada a partir da análise de conteúdo. A Classificação de risco depende das situações, queixas ou eventos da gestante, histórico, idade gestacional, comorbidades entre outros aspectos, embasado em protocolo baseado em cores e classificação de risco em obstetrícia. Os principais eventos que ocorrem na Classificação de Risco em Obstetricia estão relacionados à: sangramento vaginal, perda de liquido, contrações; hipertensão; dor na lombar; seguido de dor de cabeça; baixo peso fetal, gemelaridade e gestação de alto risco. Os desafios para o Acolhimento em Obstetrícia estão relacionados à falta de informação e conhecimento dos pacientes e acompanhantes sobre o acolhimento e classificação de risco em obstetrícia; inclusive interferindo nos procedimentos técnicos da equipe; além da demora na consulta médica mesmo quando classificado como urgência. O resultado desta pesquisa denota a importância do enfermeiro obstetra no acolhimento e Classificação de Risco, no processo de humanização, acolhimento e tomada de decisão.
A TERAPIA OCUPACIONAL NO CONTEXTO DA GESTÃO EM SAÚDE PÚBLICA NO BRASIL
Authors: Carvalho Maitê Peres de , Lima Ana Paula de Souza , Vitória Rafaela Oliveira da , Rugno Fernanda Capella
Published: November 2022

Inserida no contexto da prática administrativa, a gestão em saúde abarca uma gama de ações conectadas ao fluxo organizacional do Sistema Único de Saúde que busca viabilizar a atenção integral à saúde da população. Este artigo buscou relatar a experiência da Terapia Ocupacional junto à 7ª Coordenadoria Regional de Saúde, atuando predominantemente na regulação do sistema e destacando a importância do Terapeuta Ocupacional no processo de gestão em saúde. A principal atividade desempenhada foi a regulação de acesso no SISREG III, estabelecendo-se a classificação de risco dos usuários e, mensalmente, também eram agendadas as consultas de reabilitação física. Para o agendamento dessas consultas foram ponderados dois critérios: tempo na fila de espera e gravidade do caso. Percebeu-se que a regulação do acesso em saúde necessita de mais profissionais com expertise em reabilitação para agregar a avaliação e acompanhamento do caso clínico. O Terapeuta Ocupacional enquanto regulador do sistema tem muito a contribuir com o raciocínio clínico voltado à reabilitação física sob a ótica da ocupação humana, que é o cerne de sua formação.
Retrospective Analysis of Metastatic Bone Tumors
Authors: SEKER Nazlı Sena , CANAZ Funda , İNAN Ulukan , KAVAK Mustafa , BÜLBÜL Özge
Published: November 2022

Aim: Bone tissue is the primary organ of hematopoiesis and osteogenesis in healthy individuals. Bone tissue is one of the most frequently metastasized organs. In addition, for all types of cancer, it is an indication that cancer has reached a level where it can no longer be cured and the patient's life expectancy is reduced. The aim of this study was to retrospectively evaluate the cases operated for bone metastasis.
Material and Methods: A total of 67 patients who underwent a biopsy or operation due to bone tumors at Eskişehir Osmangazi University Medical Faculty Hospital between January 2020 and January 2022 were included in this study.
Results: Of the metastatic cases, 49 (73.1%) were male and 18 (26.9%) were female. The mean age of the patients was 61.7±19.8 (range, 9-88) years. The most frequently metastasized tumors were lung carcinoma and tumor of unknown primary in males, while lung and breast in females. Tumors most frequently metastasize to the spine region. There were 6 (9.0%) cases, 1 (1.5%) of which was mesenchymal, in which the primary origin couldn’t be detected in metastatic tumors.
Conclusion: Bone pain is always a symptom that is suspicious for metastasis in a patient followed up with a diagnosis of cancer and requires further investigation. Treatment is more palliative after bone metastasis. There is a need for targeted studies to prevent metastasis. It should be kept in mind that the primary focus may not be detected in all clinical and imaging methods in a group of patients.
Angiotensin II and atrial natriuretic peptide — unity and struggle of opposites in the model of renovascular hypertension “2 kidneys, 1 clamp”: A meta-analysis
Authors: Kuzmenko N. V. , Tsyrlin V. A. , Pliss M. G.
Published: November 2022

Background. Today, the Goldblatt model of hypertension “2 kidneys, 1 clamp” has been investigated in a large number of experimental studies. The activation of the renin-angiotensin system (RAS) underlies the development of this type of hypertension. The main buffer of the RAS is the atrial natriuretic peptide (ANP), its level is significantly increased in response to blood pressure (BP) elevation and high concentration of angiotensin II and Na+. ANP has a pronounced hypotensive effect. Clinical and experimental studies show that unilateral renovascular hypertension (URH) does not always develop even in significant stenosis of the renal artery. The purpose of this work is to investigate the activity of the RAS and the ANP, shifts in the water-electrolyte balance and renal sympathetic nervous activity via meta-analysis, to evaluate hypertensive and hypotensive mechanisms in the model of renovascular hypertension “2 kidneys, 1 clamp”. Design and methods. The meta-analysis was carried out by statistical program Review Manager 5.3 (Cochrane Library). In a meta-analysis, we used 76 publications of experimental studies of the model of renovascular hypertension in rats. Results and conclusions. The meta-analysis showed that the maintenance of URH is ensured by the high activity of the RAS and the sympathetic nervous system, as well as hypokalemia and cardiovascular remodeling. However. there is no convincing evidence of the effect of sodium-volume-dependent mechanisms on BP elevation in this model of hypertension.
The role of the sympathetic nervous system in resistant hypertension: pathophysiological and clinical aspects
Authors: Orekhov A. Yu. , Karazhanova L. K.
Published: November 2022

Resistant arterial hypertension (HTN) is a significant risk factor for cardiovascular disease and mortality. Such clinical conditions as obesity, obstructive sleep apnea and hyperaldosteronism are interrelated links of the clinical phenotype of these patients. At the same time, these conditions are interrelated by the pathophysiological basis, i.e. activity of the sympathetic nervous system. Objective. To systematize data on the role of persistent sympathetic nervous system hyperactivation in the development and progression of resistant HTN. Design and methods. We searched for clinical studies and systematic reviews in databases (PubMed, Cochrane Library) examining the role of sympathetic overdrive, as well as treatment methods for resistant HTN aimed at blocking sympathetic activation. Results. Increased activity of the sympathetic nervous system is one of the most important links in the formation of resistance to antihypertensive therapy. Moreover, it is the chronic sympathetic overdrive that unites the most common risk factors of resistant HTN, namely obstructive sleep apnea, obesity and insulin resistance, renin-angiotensin system activation, and aldosterone hyperproduction. Conclusions. The increased interest in the study of the sympathetic nervous system in recent decades has contributed to the accumulation of new data on the pathophysiological and clinical aspects of resistant HTN, as well as expanded its treatment methods by introducing into clinical practice the technique of sympathetic denervation of the renal arteries. Further study of sympathetic activation contributes to the development of new therapeutic techniques and will change the management of patients with resistant HTN.
Management of patients with hypertension, coronary heart disease and chronic heart failure during the COVID-19 pandemic in the primary care setting
Authors: Konradi A. O. , Drapkina O. M. , Nedogoda S. V. , Arutyunov G. P. , Karpov Yu. A. , Kobalava Zh. D. , Orlova Ya. A. , Sychev D. A. , Zyryanov S. K.
Published: November 2022

On December 1, 2021, a meeting of the Council of experts on the treatment of hypertension, coronary heart disease, and chronic heart failure during the COVID-19 pandemic was held remotely to adjust and adapt current approaches to outpatient treatment of the above pathologies under the current epidemiological situation. The meeting was attended by leading Russian specialists from federal medical research centers of cardiology and therapy.
Quali(a)tative Methods: Sense-Based Research in the Social Sciences and Humanities
Authors: Howes David
Published: November 2022

This paper begins by tracing the sensory turn in the human sciences—most notably, history and anthropology—which, in turn, gave rise to the interdisciplinary field of sensory studies. The latter field is articulated around the concept of the sensorium (defined as the entire sensory apparatus, including the extension of the senses via diverse media, as an operational complex) and the notion of qualia (defined as those aspects of the material world, such as color and sound, that are contingent on the human perceptual apparatus—in contrast to the inherent or elementary properties of materials, such as number or form, which are not). Sense-based research in the human sciences is tied to sensing and making sense together with others. Its methodology of choice is sensory ethnography, or “participant sensation.” This method departs from the emphasis on observation in conventional qualitative research, as well as the latter’s reliance on such verbocentric methods as the questionnaire or focus group. Sensory ethnography highlights the primacy of the quali(a)tative dimensions of our being together in society. It extrapolates on Georg Simmel’s point: “That we get involved in interactions at all depends on the fact that we have a sensory effect upon one another” (as cited in Howes 2013). In part II of this paper, a critique is presented of the diminution of the quali(a)tative in the context of the Scientific Revolution of the sixteenth and seventeenth century, the cognitive revolution of the mid-twentieth century, and the scientization of the senses in the Sensory Evaluation Research Laboratory. These revolutions are problematized for their lopsidedness: the privileging of the infrasensible over the sensible and elemental (or atomistic) over the phenomenal in the case of the Scientific Revolution; the neuronal over the sensual and social in the case of the cognitive revolution; and, the unimodal (or one-sensation- and one-sense-at-a-time) over the multimodal, as well as the reduction of “significance” to the statistical, in the case of the research protocols of the sensory science laboratory. The paper concludes by presenting the results of a series of case studies in sensory ethnography that push the bounds of sense by leading with the senses and bringing the quali(a)tative back in.
Is Homicide a Turning Point in the Life of Perpetrators? A Narrative Analysis of the Life Stories of Marginalized and Middle-Class Male Homicide Offenders in Metropolitan Buenos Aires, Argentina
Authors: Di Marco Martín Hernán
Published: November 2022

This paper aims to analyze the relevance given to violent deaths and imprisonment by male homicide perpetrators in their biographical reconstructions. Drawing on narrative criminology, this study examines the offenders’ emic terms, rationalities, and stories. The analysis is based on seventy-three purposefully selected narrative-biographical interviews and field observations in prisons and homes of former convicts (2016-2020) in Metropolitan Buenos Aires, Argentina. The corpus was analyzed following an inductive thematic coding strategy using ATLAS.ti. Three central narratives about homicide and incarceration emerged: “opportunity,” “rock bottom,” and “disruptive.” For most, homicide was described as a biographical opportunity to rethink their lives, pursue new pathways, and “stabilize” a previously uncontrolled lifestyle. However, homicides perpetrated by respondents with higher socioeconomic status were disruptive events. Participants used stoic rationality—the positive appraisal of painful experiences—to structure their sense-making and stories of violence. This rationality permeated perpetrators’ presentations of themselves, their turning points and lived experiences, and the violence performed and suffered. This paper grapples with the widespread assumption that homicide is a radical change in the lives of offenders and questions the universal meaning of violent death. Performing violence is not only neutralized but is also seen as an expected and inaugural event in life stories, dependent on the worldviews of the social actors.