bluuebunny/crossref_metadata_2025 huggingface dataset:
Cardioprotective effect of Sanguisorba minor against isoprenaline-induced myocardial infarction in rats
Authors: Hosseini Azar , Ghorbani Atieh , Alavi Mohaddeseh Sadat , Forouhi Nima , Rajabian Arezoo , Boroumand-Noughabi Samaneh , Sahebkar Amirhossein , Eid Ali H.
Published: December 2023

Introduction: Oxidative stress is a major instigator of various cardiovascular diseases, including myocardial infarction (MI). Despite available drugs, there is still an increased need to look for alternative therapies or identify new bioactive compounds. Sanguisorba minor (S. minor) is a native herb characterized by its potent antioxidant activity. This study was designed to evaluate the effect of S. minor against isoprenaline-induced MI.

Methods: Rats were treated with the hydro-ethanolic extract of the aerial parts of S. minor at doses of 100 or 300 mg/kg orally for 9 days. Isoprenaline was injected subcutaneously at the dose of 85 mg/kg on days 8 and 9. Then, the activities of various cardiac injury markers including cardiac troponin (cTnT), lactate dehydrogenase (LDH), creatinine kinase muscle brain (CK-MB), creatinine phosphokinase (CPK), and antioxidant enzymes in serum were determined. Malondialdehyde (MDA) and thiol content were measured in cardiac tissue, and histopathological analysis was conducted.

Results: Our results show that isoprenaline increased the serum levels of cTnT, LDH, CK-MB, and CPK (p < 0.001) and elevated MDA levels (p < 0.001) in cardiac tissue. Isoprenaline also reduced superoxide dismutase (SOD), catalase, and thiol content (p < 0.001). Importantly, the extract abolished isoprenaline-induced MI by elevating SOD and catalase (p < 0.001), reducing levels of MDA, and diminishing levels of cTnT, LDH, CK-MB, and CPK cardiac markers (p < 0.001). Histopathological studies of the cardiac tissue showed isoprenaline-induced injury that was significantly attenuated by the extract.

Conclusion: Our results suggest that S. minor could abrogate isoprenaline-induced cardiac toxicity due to its ability to mitigate oxidative stress.
Leaf-age and petiole biomass play significant roles in leaf scaling theory
Authors: Guo Xuchen , Schrader Julian , Shi Peijian , Jiao Yabing , Miao Qinyue , Xue Jianhui , Niklas Karl J.
Published: December 2023

Foliage leaves are essential for plant survival and growth, and how plants allocate biomass to their leaves reveals their economic and ecological strategies. Prior studies have shown that leaf-age significantly influences leaf biomass allocation patterns. However, unravelling the effects of ontogeny on partitioning biomass remains a challenge because it is confounded by the effects of environmental factors. Here, we aim to elucidate whether leaf-age affects the allocation to the lamina and petiole by examining leaves of known age growing in the same general environmental context. We sampled 2698 Photinia serratifolia leaves developing in the same environment from April to November 2021, representing eight leaf-ages (n > 300 for each leaf-age). Petiole and lamina biomass, and lamina area were measured to evaluate the scaling relationships using reduced major axis regression protocols. The bootstrap percentile method was used to determine the differences in scaling exponents among the different leaf-ages. ANOVA with Tukey’s HSD was used to compare the ratios of petiole and lamina biomass to lamina area across the leaf-ages. Correlation tests were used to determine if exponents, intercepts, and ratios differed significantly across the different leaf-ages. The data indicated that (i) the ratio of petiole and lamina biomass to lamina area and the scaling exponent of lamina biomass versus lamina area correlate positively with leaf-age, and (ii) the scaling exponent of petiole biomass versus lamina area correlates negatively with leaf-age. Leaf maturation process involves an inverse proportional allocation between lamina and petiole biomass for expanding photosynthetic area. This phenomenon underscores the effect of leaf-age on biomass allocation and the importance of adopting an ontogenetic perspective when entertaining plant scaling theories and unravelling the principles governing shifts in biomass allocation throughout the leaf lifespan.
Social support, health literacy and anxiety among pregnant women during coronavirus 2019 pandemic in Thailand
Authors: Phutong Piangkhuan , Thaithae Suparp
Published: December 2023

Background

The ongoing coronavirus disease 2019 (COVID-19) pandemic continues to have a significant impact. Pregnant women are particularly vulnerable to its effects, which may increase their anxiety levels. This study aims to investigate anxiety levels in pregnant women during the COVID-19 pandemic in Thailand and to identify factors predicting such anxiety.

Methods

The researchers collected data through an online questionnaire from November 2021 to May 2022. The sample included 404 pregnant women. The questionnaire consisted of personal information, health literacy related to COVID-19, social support, and anxiety related to COVID-19. The content validity of the questionnaire were verified by three experts, with content validity indices of 0.87, 0.80, and 0.87 for each domain, respectively. The reliability of the questionnaire were 0.96 for health literacy, 0.95 for social support, and 0.96 for anxiety. Moreover, in-depth telephone interviews were also conducted with pregnant women. The data were analyzed using descriptive statistics, stepwise multiple regression, and content analysis.

Results

Group of 404 pregnant women were studied, and the results showed that pregnant women had a high level of health literacy regarding COVID-19 and pregnancy (mean = 96.36, SD = 14.23) and social support level on a high level (mean = 83.99, SD = 11.34). Most of them were concerned about anxiety related to COVID-19 infection and pregnancy on a moderate level (mean = 47.78, SD = 11.49). The factors predicting the anxiety of pregnant women during the COVID-19 outbreak in Thailand included health literacy related to COVID-19 (β = 0.468) and social support (β = 0.283), with a prediction rate of 32.80% (R2 = 0.328) with statistical significance (p < 0.05).

Conclusion

This study revealed the anxiety level of pregnant women during the COVID-19 outbreak in Thailand, which was moderate. Health literacy about COVID-19 and social support can predict the anxiety level of pregnant women.
Functions of music, focused on the context of music listening, and psychological well-being in late adolescence regarding gender differences
Authors: Habe Katarina , Dobrota Snježana , Reić Ercegovac Ina
Published: December 2023

Late adolescences, as a developmentally challenging transitional period between childhood and adulthood, provides a number of pressures that impact well-being of youth. Among approaches for facilitating well-being, music is reported to be one of the most effective ones, which was especially proven during Covid-19 pandemic. Given the significance of music and music listening in late adolescence, our study sought to examine the relationship between psychological well-being and music listening among university students (N = 603; Nfemale = 356, Nmale = 247) with a focus on the social, intrapersonal, and sociocultural context of music listening. The RESPECT music scale, the SPWB, and the PANAS were used to measure positive and negative affect as well as the six components of psychological well-being. The findings revealed that, while there were no gender differences in the sociocultural setting, females reported to listen to music more frequently than males in intrapersonal and social contexts. In two areas, female students rated their psychological well-being higher than male students: personal growth and positive relationships with others. They also reported experiencing positive and negative affect more frequently than men. Regression analyses revealed that the functions of music explained only a small amount of the variance in psychological well-being. Specifically, music listening in a social and sociocultural context significantly explained two aspects of psychological well-being: personal growth and positive relations with others. The intrapersonal context of music listening predicted a positive affect, while the social context predicted a negative affect. Our study highlights several implications of music listening in youth regarding gender either in everyday activities or in educational and clinical setting.
Mindfulness and negative emotions among Chinese college students: chain mediation effect of rumination and resilience
Authors: Shi Keke , Feng Guoyan , Huang Qiyong , Ye Meilin , Cui Hongbo
Published: December 2023

Objective

This study examines the mediation effect of rumination and resilience between the relationship of mindfulness and negative emotions in Chinese college students.

Method

A total of 3,038 college students (19.94 ± 1.10) were investigated by Mindfulness Attention Awareness Scale (MASS), Rumination Response Style Scale (RRS), Resilience Scale (RES) and Depression-anxiety-pressure scale (DASS-21), and the mediation analyses were conducted by adopting PROCESS macro in the SPSS software.

Results

① Mindfulness was negatively associated with rumination and negative emotions (r = −0.69, −0.72; P < 0.01), and positively associated with resilience (r = 0.63, P < 0.01). Rumination was negatively associated with resilience (r = −0.59, P < 0.01), and positively associated with negative emotions (r = 0.83, P < 0.01). Resilience was negatively associated with negative emotions (r = −0.71, P < 0.01). ② Mindfulness can not only directly predict negative emotions (95%CI, −0.12~−0.09) but also affects negative emotions through three indirect paths: Rumination was a mediator (95%CI, −0.24~−0.20), resilience was a mediator (95%CI, −0.07~−0.06), and resilience and rumination were a chain mediator (95%CI, −0.04 ~ −0.03).

Conclusion

Mindfulness not only influences negative emotions directly, but also through the mediating effect of rumination and resilience indirectly.
Delayed ocular disengagement from arousing scenes
Authors: De Cesarei Andrea , Sambuco Nicola , D’Ascenzo Stefania , Nicoletti Roberto , Codispoti Maurizio
Published: December 2023

Visual exploration of the world is supported by eye movements which can be speeded up or delayed depending on bottom-up stimulation, top-down goals, and prior associations. Previous studies observed faster initiation of saccades toward emotional than neutral natural scenes; however, less is known concerning saccades which originate from emotional, compared with neutral, scenes. Here, we addressed this issue by examining a task in which participants continuously moved their gaze from and toward pictures (natural scenes), which could be emotional or neutral, and changed position in every trial. Saccades were initiated later when the starting picture was emotional compared to neutral, and this slowing was associated with the arousal value of the picture, suggesting that ocular disengagement does not vary with stimulus valence but is affected by engaging picture contents such as erotica and threat/injuries.
Individual cognitive therapy reduces frontal-thalamic resting-state functional connectivity in social anxiety disorder
Authors: Kurita Kohei , Obata Takayuki , Sutoh Chihiro , Matsuzawa Daisuke , Yoshinaga Naoki , Kershaw Jeff , Chhatkuli Ritu Bhusal , Ota Junko , Shimizu Eiji , Hirano Yoshiyuki
Published: December 2023

Introduction

Previous neuroimaging studies in social anxiety disorders (SAD) have reported potential neural predictors of cognitive behavioral therapy (CBT)-related brain changes. However, several meta-analyses have demonstrated that cognitive therapy (CT) was superior to traditional exposure-based CBT for SAD.

Objective

To explore resting-state functional connectivity (rsFC) to evaluate the response to individual CT for SAD patients.

Methods

Twenty SAD patients who attended 16-week individual CT were scanned pre- and post-therapy along with twenty healthy controls (HCs). The severity of social anxiety was assessed with the Liebowitz Social Anxiety Scale (LSAS). Multi-voxel pattern analysis (MVPA) was performed on the pre-CT data to extract regions associated with a change in LSAS (∆LSAS). Group comparisons of the seed-based rsFC analysis were performed between the HCs and pre-CT patients and between the pre-and post-CT patients.

Results

MVPA-based regression analysis revealed that rsFC between the left thalamus and the frontal pole/inferior frontal gyrus was significantly correlated with ∆LSAS (adjusted R2 = 0.65; p = 0.00002). Compared with HCs, the pre-CT patients had higher rsFCs between the thalamus and temporal pole and between the thalamus and superior/middle temporal gyrus/planum temporale (p < 0.05). The rsFC between the thalamus and the frontal pole decreased post-CT (p < 0.05).

Conclusion

SAD patients had significant rsFC between the thalamus and temporal pole, superior/middle temporal gyrus, and planum temporale, which may be indicators of extreme anxiety in social situations. In addition, rsFC between the thalamus and the frontal pole may be a neuromarker for the effectiveness of individual CT.
Prediction of patient admission and readmission in adults from a Colombian cohort with bipolar disorder using artificial intelligence
Authors: Palacios-Ariza María Alejandra , Morales-Mendoza Esteban , Murcia Jossie , Arias-Duarte Rafael , Lara-Castellanos Germán , Cely-Jiménez Andrés , Rincón-Acuña Juan Carlos , Araúzo-Bravo Marcos J. , McDouall Jorge
Published: December 2023

Introduction

Bipolar disorder (BD) is a chronically progressive mental condition, associated with a reduced quality of life and greater disability. Patient admissions are preventable events with a considerable impact on global functioning and social adjustment. While machine learning (ML) approaches have proven prediction ability in other diseases, little is known about their utility to predict patient admissions in this pathology.

Aim

To develop prediction models for hospital admission/readmission within 5 years of diagnosis in patients with BD using ML techniques.

Methods

The study utilized data from patients diagnosed with BD in a major healthcare organization in Colombia. Candidate predictors were selected from Electronic Health Records (EHRs) and included sociodemographic and clinical variables. ML algorithms, including Decision Trees, Random Forests, Logistic Regressions, and Support Vector Machines, were used to predict patient admission or readmission. Survival models, including a penalized Cox Model and Random Survival Forest, were used to predict time to admission and first readmission. Model performance was evaluated using accuracy, precision, recall, F1 score, area under the receiver operating characteristic curve (AUC) and concordance index.

Results

The admission dataset included 2,726 BD patients, with 354 admissions, while the readmission dataset included 352 patients, with almost half being readmitted. The best-performing model for predicting admission was the Random Forest, with an accuracy score of 0.951 and an AUC of 0.98. The variables with the greatest predictive power in the Recursive Feature Elimination (RFE) importance analysis were the number of psychiatric emergency visits, the number of outpatient follow-up appointments and age. Survival models showed similar results, with the Random Survival Forest performing best, achieving an AUC of 0.95. However, the prediction models for patient readmission had poorer performance, with the Random Forest model being again the best performer but with an AUC below 0.70.

Conclusion

ML models, particularly the Random Forest model, outperformed traditional statistical techniques for admission prediction. However, readmission prediction models had poorer performance. This study demonstrates the potential of ML techniques in improving prediction accuracy for BD patient admissions.
The impact of the COVID-19 pandemic on the trend of prescribing long-acting injections of paliperidone and risperidone in Central Serbia
Authors: Stojkovic Milena , Sekulic Marija , Jovanovic Mirjana , Kocovic Aleksandar , Djokovic Danijela , Minic Natasa , Djordjic Milan , Joksimovic Stefan , Sorak Marija , Stojanovic Bojan , Sretenovic Snezana , Cvetkovic Aleksandra , Stojanovic Tamara , Radmanovic Olivera , Radmanovic Branimir
Published: December 2023

Since the end of 2019, the global spread of COVID-19 has represented a historic event that changed our way of treating patients globally. The use of long-acting injections (LAI) antipsychotics was emphasized. Our goal was to investigate the impact of COVID-19 on the frequency of prescribing LAI and compare it with a period before. All patients (198) who started LAI-risperidone or LAI-paliperidone for the period 2017–2022, in Kragujevac, the city in Central Serbia, were considered. The frequency of prescribing LAI before and during COVID-19 and the total number of prescribed LAI per year were compared. Separately, the frequency of prescribing LAI-R and the frequency of prescribing LAI-P were compared. The significant (p < 0,05) increase in the use of LAI risperidone and paliperidone was in 2020 and 2021 [per year 2017(3), 2018(6), 2019(26), 2020(75), 2021(55), and 2022(33)]. The significant (p < 0,05) increase in monthly and quarterly preparations of LAI paliperidone was in 2020 and 2021 relative to the years before the pandemic. As the pandemic weakened, the inclusion of LAI paliperidone therapy weakened during 2022. A significant increase in usage of LAI risperidone was in 2022, and in 2020 and 2021 was as it was in the period 2017–2019. During COVID-19, especially in years when COVID-19 restriction measures were stricter, there was a significant change in the application method of antipsychotic therapy in favor of LAI. Regardless of the increase in treatment costs, patients’ interests and protection were prioritized in the treatment process.
Glimpse on 21st century new phobias; a predictive model of nomophobia
Authors: Ceobanu Ciprian Marius , Marian Andrei Lucian , Apostolache Roxana
Published: December 2023

The main purpose of this study was to examine the explanatory power of a predictive model of nomophobia consisting of rumination, fear of missing out (FoMO), mindfulness and non-pathological compulsions. The research involved a cross-sectional design exploring the prevalence of nomophobia in a Romanian university students’ cohort. The quantitative methodology was used to collect and analyse the data obtained from all the respondents. Researchers adapted and pretested the questionnaire NMP-Q, before distributing it to 194 university students. SPSS (V. 20) and Hayes’s PROCESS tool were used to analyse the data. The findings demonstrated that the above-mentioned psychological variables have a direct and significant relationship with nomophobia. Specifically, within the multidimensional mechanism that explains nomophobia, fear of missing out (FoMO), non-pathological compulsions, and rumination, included in the predictive model in this order, played the most important role, as together cover 34% of nomophobia variance. Furthermore, the fear of missing out has the highest explanatory contribution to nomophobia. The current study gives a better understanding of the dynamics of nomophobia in young people by focusing on psychological factors that play an important role in this phenomenon.
Control and guidance: a comparative study of building and planning standards for age-friendly built environment in the UK and China
Authors: Xie Fan , Li Xiangfeng , Li Xiaoming , Hou Zhulin , Bai Jing
Published: December 2023

The crux of building and planning standards for age-friendly built environment in all countries resides in the regulation of age-friendly built environment practices, yet there exist variations in the representation of content dimensions. The UK is distinguished by its discretionary approach to guidance, whereas China exhibits a highly controlled disposition. Control and guidance may appear to be antithetical, it is essential to recognize that the building and planning standards for age-friendly built environment in both countries never deviate from the legal constraints while providing guidance in achieving age-friendly environments, thus striking a delicate balance between control and guidance. The study examines the standard systems of national standards, local standards and organizational standards, as well as the three dimensions of foundation standards, generic standards and specialized standards. The analysis of building and planning standards for age-friendly built environment in the UK and China scrutinizes the disparities between control and guidance, identifying similarities and differences in the building and planning standard system and content dimensions of the two countries. This analysis serves as a valuable reference for the development of building and planning standards for age-friendly built environment in China.
Changes in the health status and health-related quality of life of community-dwelling older adults living alone: one-year follow-up from a cohort study
Authors: Ko Hana , Cho Belong , Lim Kyung-Choon , Jang Soong-Nang , Chang Sun Ju , Yi Yu Mi , Cho Hye Ryung , Ryu So Im , Noh Eun-Young , Park Yeon-Hwan
Published: December 2023

Background

The percentage of older adults living alone is rapidly increasing, improving the health status and health-related quality of life (HRQoL) in this group is becoming a more significant public health issue. This study aimed to examine the changes in the HRQoL of older South Korean adults living alone and identify the factors that affect their HRQoL.

Methods

A longitudinal study design was followed. Data were collected at baseline and 1-year follow-up. Participants consisting of 789 older adults living alone in S*City aged>65 years completed a cohort survey regarding health status and HRQoL from August 2018 to August 2019. Trained interviewers conducted face-to-face interviews with the participants using a validated questionnaire (physical health, mental health, social health, and HRQoL). Generalized estimating equations were used to assess the change in health status and the interaction effect of time and gender. Then, a stepwise multiple logistic regression analysis was performed to identify factors related to HRQoL.

Results

Time differences were observed in the subjective evaluation of health status (SEH), IPAQ scores, frailty, nutritional status, and depression. Gender differences were observed in the SEH, IPAQ, frailty, loneliness, depression, and social support. The interaction between time and gender was observed in the IPAQ and HRQoL. At baseline, SEH, depressive symptoms, gender, frailty, and age were associated with HRQoL. After one year, HRQoL was associated with SEH, frailty, depressive symptoms, cost of living, suicidal thoughts, gender, social support, loneliness, and suicide attempts.

Conclusion

Our results highlight that HRQoL is associated with physical health, mental health, and social support. Future detailed studies are needed to determine whether governments and communities can prevent depression, loneliness, and suicidal thoughts through psychological support and provide economic support to improve the quality of life of older adults living alone.
Pediatric central nervous system infections in the Amazon: clinical and laboratory profiles
Authors: Marinho Eveny Perlize Melo , Ferreira Ewerton da Silva , Barrionuevo Caio Cesar Leiva Bastos , Melo Sabrina Araújo , Cordeiro Jady Shayenne Mota , Pinto Sergio Damasceno , Monte Rossicleia Lins , da Silva Valderjane Aprígio , Martins Yasmin Ferreira , Reis Monique Freire , Tufic-Garutti Samantha dos Santos , Sampaio Vanderson de Souza , de Castro Daniel Barros , Feitoza Pablo Vinicius Silveira , da Rocha Lucia Alves , de Lima Ferreira Luiz Carlos , Bastos Michele de Souza
Published: December 2023

Background

Central nervous system (CNS) infections are important causes of mortality and morbidity in children, and they are related to severe problems such as hearing loss, neurological sequelae, and death. The objective was to describe clinical and laboratory exam profiles of children who were diagnosed with CNS infections.

Methods

We conducted a cross-sectional study based on medical records, which included pediatric patients aged from 3 months to 15 years, with a clinical suspicion of CNS infection between January 2014 to December 2019. The pathogens were confirmed in cerebrospinal fluid (CSF) samples using Gram staining, cell culture, molecular diagnostics (PCR and qPCR), and serology.

Results

Out of the 689 enrolled patients, 108 (15.6%) had laboratory-confirmed infections in CSF. The most common bacterial pathogens isolated from the culture were Neisseria meningitidis serogroup C in 19, Streptococcus pneumoniae in 11, and Haemophilus influenzae in seven samples. The viruses identified were Enterovirus, Cytomegalovirus, Varicella-zoster virus, Epstein–Barr virus, and arbovirus. No patient was found to be positive for Herpes simplex virus 1 and 2. Patients with viral infections showed altered levels of consciousness (p = 0.001) when compared to bacterial infections.

Conclusion

This study shows the presence of important vaccine-preventable pathogens, and different families of viruses causing CNS infections in the pediatric patients of Manaus.
Greening and Water Use Efficiency during a period of high frequency of droughts in the Brazilian semi-arid
Authors: Rezende Luiz Felipe , Alves Lincoln , Barbosa Alexandre Augusto , Sales Aldo Torres , Pedra George Ulguim , Menezes Rômulo Simões Cézar , Arcoverde Gustavo Felipe , Ometto Jean Pierre
Published: December 2023

A discussion that has occurred in the scientific community is that despite the increase in the frequency of droughts, the semi-arid world may be increasing the density of vegetation due to fertilization by the increase in atmospheric CO2, a phenomenon called “greening.” Through this study, we sought to evaluate and discuss whether this “greening” would also be occurring in the Brazilian semiarid and what would be its contribution or counterpoint about droughts. Another topic covered was Water Use Efficiency (WUE), about its contribution to mitigating droughts. We chose eight study areas in which the native vegetation was preserved for periods of around 20 years or more. We used data from the Leaf Area Index (LAI), Gross Primary Productivity (GPP), precipitation, evaporation, transpiration, and soil moisture. We divided into two distinct periods to calculate the means of these variables. We applied the Standardized Precipitation Index (SPI) to identify the frequency of droughts for the period from 1961 to 2020. It was observed that between 2001 and 2020, there was an increase in the relative frequency of extreme and exceptional droughts around 19 and 11%, respectively. Our results showed evidence of “greening” for only two sites that were less impacted by droughts, and it seems that the CO2 fertilizer effect could not compensate for the scarcity of water in the other locations of our study. However, WUE was present in almost all sites, which may be a factor in mitigating the impacts of the high frequency of droughts.
Use of subject-specific models to detect fatigue-related changes in running biomechanics: a random forest approach
Authors: Dimmick Hannah L. , van Rassel Cody R. , MacInnis Martin J. , Ferber Reed
Published: December 2023

Running biomechanics are affected by fatiguing or prolonged runs. However, no evidence to date has conclusively linked this effect to running-related injury (RRI) development or performance implications. Previous investigations using subject-specific models in running have demonstrated higher accuracy than group-based models, however, this has been infrequently applied to fatigue. In this study, two experiments were conducted to determine whether subject-specific models outperformed group-based models to classify running biomechanics during non-fatigued and fatigued conditions. In the first experiment, 16 participants performed four treadmill runs at or around the maximal lactate steady state. In the second experiment, nine participants performed five prolonged runs using commercial wearable devices. For each experiment, two segments were extracted from each trial from early and late in the run. For each participant, a random forest model was applied with a leave-one-run-out cross-validation to classify between the early (non-fatigued) and late (fatigued) segments. Additionally, group-based classifiers with a leave-one-subject-out cross validation were constructed. For experiment 1, mean classification accuracies for the single-subject and group-based classifiers were 68.2 ± 8.2% and 57.0 ± 8.9%, respectively. For experiment 2, mean classification accuracies for the single-subject and group-based classifiers were 68.9 ± 17.1% and 61.5 ± 11.7%, respectively. Variable importance rankings were consistent within participants, but these rankings differed from each participant to those of the group. Although the classification accuracies were relatively low, these findings highlight the advantage of subject-specific classifiers to detect changes in running biomechanics with fatigue and indicate the potential of using big data and wearable technology approaches in future research to determine possible connections between biomechanics and RRI.
Endophytic fungi: versatile partners for pest biocontrol, growth promotion, and climate change resilience in plants
Authors: Fite Tarekegn , Kebede Erana , Tefera Tadele , Bekeko Zelalem
Published: December 2023

Plant-associated endophytic fungi (EFs) are emerging as a promising solution to advancing modern agriculture and fostering environmental sustainability, especially in the face of climate change scenarios. These fungi, either naturally residing in plants or introduced through artificial inoculation techniques, improve agricultural production due to their various roles in protecting and supporting host plants. The majority of EFs serve as natural biocontrol agents for a variety of agricultural pests, such as insects, phytopathogens, nematodes, and weeds. Notably, EFs produce secondary metabolites, trigger immune responses, modify plant defense gene expression, confer host plant resistance and/or tolerance, and regulate pest growth, populations, and survival to combat agricultural pests. Beyond controlling pests, EFs promote optimal plant growth, development, and resilience by aiding in the synthesis of vital compounds such as phytohormones and bioactive metabolites, nutrient acquisition, and fortifying plants against environmental stresses and climatic changes. Moreover, the mostly nonpathogenic nature of EFs, coupled with their high yield potential, environmental safety, and cost effectiveness, positions them as eco-friendly and economically viable alternatives to synthetic agrochemicals amidst rapid climate change scenarios. As a result, the promising horizon of EFs in agricultural production necessitates interdisciplinary study and microbial modulation approaches to optimize symbiotic plant-EF relationships and their potential for improved productivity. This review provides current and comprehensive insights into the practical applications and multifaceted benefits of EFs in pest management, plant growth promotion, and climate change resilience for future agricultural production improvements. The analysis reveals the potential of developing EFs into innovative bioformulations such as biofertilizers, biostimulants, and biopesticides, thereby paving the way for their integration into a sustainable and more resilient future agricultural system.
Influenza risks arising from mixed intensive pig and poultry farms, with a spotlight on the United Kingdom
Authors: Mace Jenny L. , Knight Andrew
Published: December 2023

Diseases passed to humans from animals (zoonoses) constitute 75% of emerging infectious diseases. Farmed animals are considered a high zoonotic risk, especially poultry and pigs as evidenced by recent outbreaks of avian and swine influenza. This review sought to collate recent knowledge of the disease risks from keeping pigs and chickens intensively and in close proximity to each other. Recent knowledge on influenza viruses compounds the public health concerns; no longer are concerns about “mixing vessel” hosts limited to pigs, but several other animal species too at a high level of probability—most notably chickens and humans. More generally, scientific literature establishing positive associations between intensive animal farming, human population growth, reduced biodiversity, and increased zoonoses risks is abundant. This includes the publication of relevant systematic reviews. The collected scientific evidence on this issue is clear: there is exceptionally strong evidence for a link between low animal welfare levels and high zoonotic risks, exacerbated by animal crowding, low genetic diversity, compromised hygiene, and high animal stress levels which compromise immune systems. Based on this evidence, further industrialized animal farms—especially poultry and pig farms or a mix thereof, and particularly in areas that already have a high concentration of farmed animals—should not generally be permitted to proceed. Instead, efforts should concentrate on supporting arable agriculture (or transitions toward this) and de-intensifying remaining animal farms, in alignment with One Health/One Welfare approaches within which animal health and welfare are integral parts of any farming operation. Among numerous other factors, this would involve reducing stocking densities down to 11 kg/m2 (around five chickens/m2) for meat chickens, and down to one pig/1.5 m2 for pigs (assuming a 100 kg pig).
Versatile, vigilance, and gut microbiome support the priority of high-ranking hens
Authors: Xie Zhijiang , Xing Limin , Zhao Mengqiao , Zhao Lei , Liu Jinling , Li Yushan , Gan Jiankang , Chen Siyu , Li Hua
Published: December 2023

Dominance hierarchy exists in social animals and shows profound impacts on animals’ survival, physical and mental health, and reproductive success. Aggressive interaction, as the main indicator used to calculate social hierarchy, however, is not found in some female animals. In this study, we aimed to figure out the establishment of social hierarchy in hens that almost perform aggressive behaviors and investigated the interactions of social hierarchy with production performance and gut microbiome. Forty 49-day-old Qingyuan hens were randomly divided into four groups. The social hierarchy of hens was calculated by the relative position around the feeder. The rank 1 (R1), R2, R3, R4, R5, R6, R7, R8, R9, and R10 birds were determined in ascending order. Then, R1 and R2 birds (four duplicates, n = 8) were named as the high-ranking hens (HR) group, while R9 and R10 individuals were named as the low-ranking hens (LR) group (four duplicates, n = 8). The heart index (p = 0.01), number of visits per day, daily feed intake, and occupation time per day were higher in the HR group than LR group, but the LR group had a higher feed intake per visit than the HR group. The alpha diversity was significantly lower in the HR group than the LR group (p = 0.05). The relative abundance of phylum Firmicutes was higher while that of phylum Deferribacterota was lower in the HR group than LR group (p < 0.05). At the genus level, the relative abundance of Succinatimonas, Eubacterium hallii group, and Anaerostipes were higher in HR group than in LR group. The relative abundance of Bacteroides, Mucispirillum, Subdoligranulum, and Barnesiellaceae unclassified was higher in the LR group than HR group (p < 0.05). In conclusion, the rank of hens could be calculated by the relative position around the feeder when they compete for food. The dominant hens have a versatile. Moreover, they are more vigilant and have priority when foraging. Low-ranking hens adopt strategies to get enough food to sustain themselves. Hens of high-rank possess beneficial bacteria that use favorable substances to maintain the balance of the gut environment.
Pancreatic SABR using peritumoral fiducials, triggered imaging and breath-hold
Authors: Kisivan Katalin , Farkas Andrea , Kovacs Peter , Glavak Csaba , Lukacs Gabor , Mahr Karoly , Szabo Zsolt , Csima Melinda Petone , Gulyban Akos , Toth Zoltan , Kaposztas Zsolt , Lakosi Ferenc
Published: December 2023

Background: We aim to present our linear accelerator-based workflow for pancreatic stereotactic ablative radiotherapy (SABR) in order to address the following issues: intrafractional organ motion management, Cone Beam CT (CBCT) image quality, residual errors with dosimetric consequences, treatment time, and clinical results.

Methods: Between 2016 and 2021, 14 patients with locally advanced pancreatic cancer were treated with induction chemotherapy and SABR using volumetric modulated arc therapy (VMAT). Internal target volume (ITV) concept (5), phase-gated (4), or breath hold (5) techniques were used. Treatment was verified by CBCT before and after irradiation, while tumor motion was monitored and controlled by kV triggered imaging and beam hold using peritumoral surgical clips. Beam interruptions and treatment time were recorded. The CBCT image quality was scored and supplemented by an agreement analysis (Krippendorff’s-α) of breath-hold CBCT images to determine the position of OARs relative to the planning risk volumes (PRV). Residual errors and their dosimetry impact were also calculated. Progression free (PFS) and overall survival (OS) were assessed by the Kaplan-Meier analysis with acute and late toxicity reporting (CTCAEv4).

Results: On average, beams were interrupted once (range: 0–3) per treatment session on triggered imaging. The total median treatment time was 16.7 ± 10.8 min, significantly less for breath-hold vs. phase-gated sessions (18.8 ± 6.2 vs. 26.5 ± 13.4, p < 0.001). The best image quality was achieved by breath hold CBCT. The Krippendorff’s-α test showed a strong agreement among five radiation therapists (mean K-α value: 0.8 (97.5%). The mean residual errors were <0.2 cm in each direction resulting in an average difference of <2% in dosimetry for OAR and target volume. Two patients received offline adaptation. The median OS/PFS after induction chemotherapy and SABR was 20/12 months and 15/8 months. No Gr. ≥2 acute/late RT-related toxicity was noted.

Conclusion: Linear accelerator based pancreatic SABR with the combination of CBCT and triggered imaging + beam hold is feasible. Peritumoral fiducials improve utility while breath-hold CBCT provides the best image quality at a reasonable treatment time with offline adaptation possibilities. In well-selected cases, it can be an effective alternative in clinics where CBCT/MRI-guided online adaptive workflow is not available.
Cut, Copy, Paste: Yu Youhan and the Refashioning of China’s Past
Authors: Langefeld Maximilian Leopold
Published: December 2023

Best known for his lush landscapes and geometrical abstracts, Shanghai-born artist Yu Youhan 余友涵 (b. 1943) has frequently been in the limelight of curatorial and scholarly activities. Yet his vibrant pop works, which capture decisive moments in modern Chinese history, have insufficiently been considered mere juxtapositions of imagery derived from socialist China, political figures of the time, and commerce. This article offers new insights into the mechanics of signification in the artist’s Political Pop works by examining the ways in which different kinds of imagery are appropriated, manipulated and recontextualised. Three in-depth semiotic analyses counter the assumption that Yu’s copy-and-paste practice might indicate a lack of originality or even the decay of Political Pop, which had come to a halt in his practice by the early 2000s. Rather, the various acts of appropriation prove to be astute artistic strategies that reinforce the artist’s originality and criticality. By emptying and recoding individual signifiers, Yu’s work blurs the line between fact and fiction and challenges stable narratives usually expressed in official history paintings. In other words, the artist gives birth to a contemporary form of history painting, or rather an anti-history painting, in the style of Political Pop that refashions the cultural memory of China’s past.
Trauma Responses in Social Choreography: Accessing Agency and Opportunities for Healing through Mindful Embodiment
Authors: Cabeen Catherine
Published: December 2023

This article responds to the questions: how does trauma that is long-held in the body affect social choreography? And how can awareness of this intersection guide us towards individual and collective healing practices? Embodied trauma responses, commonly referred to as fight, flight, freeze, and dissociation, initially function as potentially lifesaving responses to external threats but all too often become engrained in how people move through the world and relate to one another. When these patterns of engagement become habituated, they affect the improvisational scores inherent to social choreography. Exploring trauma responses through the lens of social choreography invites increased awareness of how these patterns of behavior affect our relationships and communities. Through this awareness, the possibility of agency is increased. This essay continues the work of somatic and cultural scholars Resmaa Menakem, Staci K. Haines, and Zhiwa Woodbury, among others, whose research points to multiple continuums between how trauma is individually embodied and cultural dynamics we are experiencing globally. Drawing on the somatic work of Peter Levine and Bessel Van der Kolk, whose theories have revolutionized trauma healing, this essay offers accessible pathways to trauma sensitivity that readers can experiment with to consciously refine their own roles in social choreographies ranging from interpersonal to cultural interactions.
Evaluating the Aging-Induced Voltage Slippery as Cause for Float Currents of Lithium-ion Cells
Authors: Azzam Mohamed , Endisch Christian , Lewerenz Meinert
Published: December 2023

This paper provides a comprehensive exploration of float current analysis in lithium-ion batteries, a promising new testing method to assess calendar aging. Float currents are defined as the steady-state trickle charge current after a transient part. In the literature, a correlation to capacity loss was reported. Assuming the float current compensates for the voltage decay over time and is linked to calendar aging, effects from voltage slippery must be considered. The dU/dQ analysis suggests solely a loss of active lithium. Therefore, we investigate the solid electrolyte interphase (SEI) growth as the general aging mechanism to explain the origin of float currents. Our results show that the voltage slippery theory holds true within the low to middle test voltage ranges. However, the theory’s explanatory power begins to diminish at higher voltage ranges, suggesting the existence of additional, yet unidentified, factors influencing the float current. A shuttle reaction or lithiation of the cathode by electrolyte decomposition are the most promising alternative aging mechanisms at high voltages. The paper proposes a unique voltage slippery model to check for correlations between aging mechanisms, the float current test and the check-up test. For a better understanding, test strategies are proposed to verify/falsify the aging mechanisms beyond SEI.
Oncogenic BRCA1,2 Mutations in the Human Lineage—A By-Product of Sexual Selection?
Authors: Korneenko Tatyana V. , Pestov Nikolay B.
Published: December 2023

In this review, we discuss the long-known problem of tissue-specific carcinogenesis in BRCA1 and BRCA2 mutation carriers: while the genes are expressed ubiquitously, increased cancer risk is observed mostly in the breast and ovaries, and to a much lesser extent, in some other tissues such as the prostate or pancreas. We reevaluate hypotheses on the evolutionary origin of these mutations in humans. Also, we align together the reports that at least some great apes have much lower risks of epithelial cancers in general and breast cancer in particular with the fact that humans have more voluminous breast tissue as compared to their closest extant relatives, particularly chimpanzees and bonobos. We conjecture that this disparity may be a consequence of sexual selection, augmented via selection for enhanced lactation. Further, we argue that there is an organ-specific enigma similar to the Peto paradox: breast cancer risk in humans is only minimally correlated with breast size. These considerations lead to the hypothesis that, along with the evolutionary development of larger breasts in humans, additional changes have played a balancing role in suppressing breast cancer. These yet-to-be-discovered mechanisms, while purely speculative, may be valuable to understanding human breast cancer, though they may not be exclusive to the mammary gland epithelial cells. Combining these themes, we review some anti-carcinogenesis preventive strategies and prospects of new interventions against breast cancer.
Cellular Senescence in Liver Cancer: How Dying Cells Become “Zombie” Enemies
Authors: Gazzillo Aurora , Volponi Camilla , Soldani Cristiana , Polidoro Michela Anna , Franceschini Barbara , Lleo Ana , Bonavita Eduardo , Donadon Matteo
Published: December 2023

Liver cancer represents the fourth leading cause of cancer-associated death worldwide. The heterogeneity of its tumor microenvironment (TME) is a major contributing factor of metastasis, relapse, and drug resistance. Regrettably, late diagnosis makes most liver cancer patients ineligible for surgery, and the frequent failure of non-surgical therapeutic options orientates clinical research to the investigation of new drugs. In this context, cellular senescence has been recently shown to play a pivotal role in the progression of chronic inflammatory liver diseases, ultimately leading to cancer. Moreover, the stem-like state triggered by senescence has been associated with the emergence of drug-resistant, aggressive tumor clones. In recent years, an increasing number of studies have emerged to investigate senescence-associated hepatocarcinogenesis and its derived therapies, leading to promising results. In this review, we intend to provide an overview of the recent evidence that unveils the role of cellular senescence in the most frequent forms of primary and metastatic liver cancer, focusing on the involvement of this mechanism in therapy resistance.
Residue Number System (RNS) and Power Distribution Network Topology-Based Mitigation of Power Side-Channel Attacks
Authors: Selvam Ravikumar , Tyagi Akhilesh
Published: December 2023

Over the past decade, significant research has been performed on power side-channel mitigation techniques. Logic families based on secret sharing schemes, such as t-private logic, that serve to secure cryptographic implementations against power side-channel attacks represent one such countermeasure. These mitigation techniques are applicable at various design abstraction levels—algorithm, architecture, logic, physical, and gate levels. One research question is when can the two mitigation techniques from different design abstraction levels be employed together gainfully? We explore this notion of the orthogonality of two mitigation techniques with respect to the RNS secure logic, a logic level power side-channel mitigation technique, and power distribution network (PDN), with the decoupling capacitance, a mitigation technique at physical level. Machine learning (ML) algorithms are employed to measure the effectiveness of power side-channel attacks in terms of the success rate of the adversary. The RNS protected LED block cipher round function is implemented as the test circuit in both tree-style and grid-style PDN using the FreePDK 45 nm technology library. The results show that the success rate of an unsecured base design 68.96% for naive Bayes, 67.44% with linear discriminant analysis, 67.51% for quadratic discriminant analysis, and 66.58% for support vector machine. It is reduced to a success rate of 19.68% for naive Bayes, 19.62% with linear discriminant analysis, 19.10% for quadratic discriminant analysis, and 10.54% in support vector machine. Grid-type PDN shows a slightly better reduction in success rate compared to the tree-style PDN.