bluuebunny/crossref_metadata_2025 huggingface dataset:
Sitotoksisitas dan Selektivitas Fraksi Kayu Batang Simpur Air (Dillenia suffruticosa (Griff.) Martelli) Terhadap Sel Kanker Payudara
Authors: Nurdiani Eka , Masriani Masriani , Rasmawan Rahmat , Muharini Rini , Sartika Rody Putra
Published: December 2023

AbstrakKanker payudara didiagnosis menjadi penyebab utama kematian pada wanita di seluruh dunia. Beberapa penelitian terdahulu telah membuktikan bahwa tanaman simpur air (Dillenia suffruticosa (Griff.) Martelli) dapat menjadi agen antikanker yang potensial. Penelitian ini bertujuan untuk menentukan sitotoksisitas dan selektivitas dari fraksi kayu batang simpur air terhadap sel kanker payudara T47D, MCF-7, dan 4T1. Metode penelitian adalah eksperimental laboratorium dan uji aktivitas antikanker terhadap sel kanker payudara dilakukan secara in vitro menggunakan sel kanker payudara T47D, MCF-7, dan 4T1. Proses ekstraksi kayu batang simpur air menggunakan metode maserasi dengan pelarut metanol, selanjutnya difraksinasi dengan pelarut n-heksana dan etil asetat secara berturut-turut dan diuji aktivitas sitotoksiknya dengan metode MTT [3-(4,5-dimetiltiazol-2-il)-2,5 difeniltetrazolium bromida] assay. Hasil yang diperoleh, yaitu fraksi n-heksana menunjukkan sifat sitotoksik sedang pada sel kanker payudara T47D, MCF-7, dan 4T1 dengan nilai IC50 berturut-turut sebesar 65,27 ± 26,17; 66,98 ± 0,97; dan 69,23 ± 6,25 µl/mL dengan IS>2. Dengan demikian, fraksi n-heksana kayu batang simpur berpotensi dikembangkan sebagai antikanker baru.AbstractBreast cancer is diagnosed as the leading cause of death in women worldwide. Several previous studies have proven that the simpur air plant (Dillenia suffruticosa (Griff.) Martelli) can be a potential anticancer agent. This study aims to determine the cytotoxicity and selectivity of the simpur air stem wood fraction against T47D, MCF-7, and 4T1 breast cancer cells. This research is laboratory experimental and the anticancer activity test against breast cancer cells was carried out in vitro. The extraction process for Simpur Air wood stems uses the maceration method with methanol solvent, then fractionated with n-hexane and ethyl acetate solvents successively and tested for cytotoxic activity using the MTT method [3-(4,5-dimethylthiazol-2-yl)-2 .5 diphenyltetrazolium bromide] assay. The results obtained, namely the n-hexane fraction showed moderate cytotoxic properties on T47D, MCF-7, and 4T1 breast cancer cells with IC50 values of 65.27 ± 26.17 respectively; 66.98 ± 0.97; and 69.23 ± 6.25 µl/mL with IS>2. Thus, the n-hexane fraction of simpur stem wood has the potential to be developed as a new anticancer.
“Jesus no controle”
Authors: Macedo de Novaes Allan
Published: December 2023

No contexto cristão, especialmente entre grupos conservadores, há uma variedade de respostas sobre o consumo de jogos digitais, que vão desde críticas duras a elogios entusiásticos. Diante disso, comunidades e ambientes digitais de “gamers cristãos” procuram ressignificar o engajamento dos fieis com jogos eletrônicos, imbuindo nessa vivência elementos identitários típicos da compreensão do papel ferramental que o lúdico deveria ocupar nas vivências do religioso. Um dos elementos em que essa ressignificação é mais notável e que é muito presente nesses ambientes é a resenha de jogos (em inglês, game review). Essa modalidade literário-jornalística mostra-se oportuna para a identificação de uma forma elementar da filosofia cristã sobre os jogos. Logo, nessa relação de tensão entre os cristãos e os games, o presente trabalho se propõe a identificar alguns dos pressupostos morais e teológicos que estão presentes nessa relação conflituosa, com base em critérios de avaliação de resenhas/críticas de jogos em sites de gamers cristãos de língua inglesa e portuguesa. Portanto, por meio de elementos de análise do conteúdo, o artigo realizou um levantamento comparativo dos critérios de resenhas de jogos nesses sites identificando que a maioria utiliza como critérios de avaliação de jogos metodologias de classificação indicativa de games, assim como a presença de elementos não-cristãos na narrativa e mecânicas dos jogos.
Catolicismo y Revolución cubana: apuntes imprescindibles - décadas de 1970 y 1980 (Parte 2)
Authors: Trujillo Lemes Maximiliano Francisco , Teodoro da Silva Wellington
Published: December 2023

La implementación del ateísmo estatal continuó durante toda la década de 1980. A pesar de ello, este período es comúnmente reconocido como un momento de diálogo entre la Iglesia católica y el Estado socialista hasta su segunda mitad. A partir de entonces, la institución religiosa pasó a la ofensiva, creyendo que el régimen insular seguía el mismo camino de decadencia que atravesaba Europa del Este. En esta segunda parte de este artículo abordamos esta década con especial atención al Encuentro Eclesial Nacional Cubano – ENEC – que entendemos como el evento más importante del catolicismo.
Az épített történeti környezetek konnotatív jelentése: műemléki szakértők és nem szakértők jelentésdimenzióinak feltárása
Authors: Fogarasi Barbara , Berze Iván Zsolt , Dúll Andrea
Published: December 2023

Háttér és célkitűzések: Az épített környezet jelenlétét gyakran nem tudatosuló módon élik meg az emberek, miközben az épületek, terek sok szinten befolyásolják az aktuális érzelmi állapotot, a viselkedést, a jóllétet stb. A történeti épületek és helyszínek hatása abból a szempontból is hangsúlyos, hogy meghatározzák az emberek egyéni és kollektív identitását. A műemlékekkel való foglalkozás egyfelől a témában képzett szakemberek tisztje, akik számára az épületből, a helyszínből fakadó történetiség és hitelesség a legfontosabb, másfelől a nem szakértők, a laikusok ugyanazon épülethez a mindennapi életben átélt értékeket és (konnotatív) jelentéseket társítanak. Módszer: Kutatásunkban ezen eltérő konnotatív jelentések feltárására az általunk fejlesztett szemantikus differenciál mérőeszközt alkalmazzuk. Tanulmányunkban a kifejezetten műemlékekre alkalmazható skála fejlesztésének módszertani lépéseit és a mérőeszköz két mintán (műemléki szakértő és laikus) való alkalmazásából kapott eredmények összehasonlítását mutatjuk be. Eredmények: A főkomponens-elemzés során szakértők esetében hat (arousal-kogníció, komplexitás, emberközeliség, érték, állag-hangulat, hitelesség), laikusok esetében négy komponenst (érték, komplexitás, emberközeliség, állag) kaptunk. Következtetések: Eredményeink szerint a műemléki szakértők ugyan kifinomultabban gondolkodnak a műemlékekről, de több komponens esetében a laikusokéhoz nagyon hasonló módon jelentek meg a melléknévpárok, jelezve a szakemberek és a laikus használók kapcsolódásának lehetőségét a látens érzelmi viszonyulások szintjén. A szakmai értékek mellett megjelenő pszichológiai jelentések feltárásával, az épülethasználók bevonásával, a mindennapi emberek helyidentitásának és helykötődésének megerősítésével hosszú távon mindenki – a laikus helyhasználók, a szakemberek és a történeti épületek – jól járhat.
Rail transport electric drive with intelligent control system
Authors: Kyrylenko Yaroslav , Senchenko Serhii , Vorobiov Bohdan , Khan Liu , Likhno Yaroslav
Published: December 2023

Purpose. The study of the conditions for the occurrence of frictional self-oscillations, the synthesis of a neuroregulator eliminating self-oscillation, the development of a system for automatic control of the of railway transport speed depending on the curvature of the track on the basis of computer vision technology.
Methodology. Mathematical analysis and modeling.
Findings. The paper presents the results of the development and research of an intelligent control system for the electric drive of a DS3 mainline electric locomotive. The developed systems have a single easily implemented motor speed feedback, which does not create difficulties in physical implementation. It is noted that a common feature of the electric drive of rail transport is a nonlinear load characteristic. It is shown that, under certain combinations of parameters, frictional self-oscillations are possible in the traction electric drive. Effective elimination of frictional self-oscillations is done  by synthesizing the system with a neuroregulator. The neural network has three input neurons that receive a vector of input signals in the form of a voltage signal, a signal of the motor speed value of the current and previous energy speed values. The number of neurons in the hidden layer of the system is 20 and there is one output neuron.The control actions for the frequency converter are formed on the output neuron. Neural networks of this type are designated NN3-20-1. The genetic algorithm method is used for all optimization of neural network parameters. The simulation model of the electric drive of rail transport has the integration of a computer vision unit. Increasing the level of automation and safety of rail vehicles is possible on the basis of computer vision. A feature of this structure is the presence of an NN neural regulator in it. NN ensures the specified quality of the transient process over the entire load range and when the operating point is located on a falling section. A system for automatic control of the speed of rail vehicles depending on the curvature of the track has been developed to increase the level of automation and traffic safety. Modeling of the system showed its efficiency, which is manifested in a decrease in the speed of rail vehicles when moving along a section of track with curvature.
Originality.  Effective elimination of frictional self-oscillations due to the use of a neuroregulator.
Practical value.  A system for automatically adjusting the speed of rail transport depending on the curvature of the track has been developed to increase the level of automation and traffic safety.
Study of the influence of the current distortion power of the secondary winding of a transformer on the level of losses in it using the method of experiment planning
Authors: Bezzub Maksim , Bialobrzheskyi Olexii , Yakumec Sergey , Oliynichenko Maksim , Postil Artur
Published: December 2023

Purpose. Detection the relationship between the level of losses of a three-phase transformer and the power of distortion caused by current harmonics..
Methodology. During the research, the methods of determining power losses and additional losses in the elements of the electrical system from higher current and voltage harmonics, the visual programming method, the experiment planning method, and the orthogonal central composite plan method were used.
Findings. An analysis of the indicators characterizing voltage and current distortions was carried out, and it was found that these distortions are most fully characterized by the current distortion power and voltage distortion power. These indicators are used to analyze the transmission of electric energy by a transformer of a traction substation. It is noted that the order of harmonics in the distortion power is not eliminated, and higher harmonics are taken into account by the corresponding effective current of higher harmonics. The specifics of the transformer secondary winding connections to the consumer, namely the grounding of one of the secondary winding phases, were taken into account. A number of combinations of current harmonics were used to simulate current distortions. The experiment was carried out using the planning method. The coefficients of the quadratic regression equation that relates power losses to the level of load current harmonics of the third, fifth, and seventh orders are obtaine To determine the significance of the obtained coefficients of the regression equation, the variances and the corresponding values of the Student's criterion were calculated, as a result, factors that do not affect the process and can be excluded from the regression equation were identified. The adequacy of the obtained regression equation was checked by Fisher's criterion. The analysis of the effects and their interaction showed that the standard error of the sample does not exceed 1.66%. As a result of analyzing the combinations of current harmonics that were set during the experiment, it was noted that some of them lead to the same effective phase current, while the power of current distortion is different. The greatest significance of the level of the third harmonic of the current is determined. The constant level of active power on the high voltage side of the transformer is noted, which is due to the absence of voltage distortions on it.
Originality. Cases of combinations of current harmonic levels at which the current distortion power index remains unchanged, while the level of transformer power losses caused by current harmonics changes, have been identified.
Practical value. This research can be used to assess and reduce the level of power losses in a transformer by filtering certain current harmonics.
Current situation and health risk assessment of neonicotinoids insecticides in urban indoor dust from Ha Noi, Viet Nam
Authors: Ho Hoang Nguyen , Trinh Ha Thu , Tran Manh Duy , Duong Hanh Thi , Dinh Cuc Thi
Published: December 2023

In the several decades, although neonicotinoids insecticides (typically imidacloprid and thiamethoxam) are widely used and account for 24 % of the total global pesticide production, they still have negative impacts on natural enemies such as kinds of bees as well as adversely affect human health. However, there are only a few studies evaluating the levels of imidacloprid and thiamethoxam in airborne environments including indoor dust. Therefore, the aim of this study was to investigate the distribution, concentration and health risk to human of imidacloprid and thiamethoxam in indoor dust samples collected from 6 inner districts of Hanoi. Imidacloprid was found in indoor dust samples at all samples with an average concentration of 0.079 µg/g (ranging from 0.028 to 0.216 µg/g, the detection frequency of 100 %). Meanwhile, the mean concentration of thiamethoxam was revealed lower than imidacloprid at 0.013 µg/g (ranging from 0.01 to 0.027 µg/g, the detection frequency of 60 %). In high-end exposure, based on the measured concentrations, daily intake doses (IDs) of imidacloprid and thiamethoxam were calculated to be 9.96 × 10-1 and 1.10 × 10-2 ng/kg-bw/day for adults, and 1.78 and 1.98 × 10-1 ng/kg-bw/day for children, respectively. The estimated values of hazard quotient (HQ) of imidacloprid and thiamethoxam were 1.75 × 10-6 and 9.20 × 10-7 ng/kg-bw/day for adults, and 3.13 × 10-5 and 1.65 × 10-5 ng/kg-bw/day for children, respectively. All HQ and HI values of the insecticides were less than 1 for both of adults and children, indicating the potential adverse effects to human health are negligible.
Genetic diversity and some biological characteristics of antibacterial yeasts isolated from natural honey and beeswax in Son La province
Authors: Pham Anh Ngoc , Ha Anh Kieu , Tran Thuy Thi
Published: December 2023

Yeast living in honey, an environment with high sugar content (up to 70 %, w/v), normally shows good resistance to the high level of osmotic pressure; they are of high potential for application in many fields. There were not many studies on the genetic diversity and biological characteristics of yeast from honey in Vietnam. This study aims to (1) evaluate the genetic diversity of antibacterial yeast isolated from natural honey and beeswax in Son La province by RAPD (Random Amplified Polymorphic DNA) and (2) study some biological characteristics of them. The research results may contribute to the scientific basis for screening yeast strains applied in different fields such as bioethanol and probiotic production. Sixty-eight yeast strains were isolated from natural honey and beeswax collected in Son La. Among them, twenty-one strains showed antibacterial activity against at least a tested bacterium including Escherichia coli, Bacillus subtilis, and Serratia marcescens. These yeast strains were genetically distinct in the RAPD analysis using M13 and (GTG)5 primers. Evaluation of yeast growing in the medium containing high glucose concentration (30 - 40 %, w/v) or high ethanol concentration (5 - 10 %, v/v) has shown some yeast strains that can tolerate high osmotic pressure and high ethanol concentration for different applications. YC.8 and YC.61 strains exhibited relatively good survival rates in two phases of digestion and have a wide pH range (2 - 7). YC.8 strain expressed the most potential for human or animal probiotics.
Antibiotic resistance characteristics of potential probiotic Lactobacillus strains
Authors: Dang Huong Thu , Dinh Huy Son , Loc Tu Anh , Nguyen La Anh
Published: December 2023

Antibiotic-resistant bacteria are increasingly common and threaten human health. Recently, antibiotic resistance in food associated bacteria become an emerging threat to this state. These bacteria may act as reservoirs of antibiotic resistance genes and transfer to commensal or pathogenic bacteria in the human intestines. Therefore, either probiotics or starter cultures have to be evaluated for antibiotic interaction. In this study, the antibiotic susceptibility of seven Lactobacillus strains was determined. The MIC values revealed that all strains were resistant to tetracycline, ciprofloxacin, vancomycin and aminoglycoside antibiotics group (gentamicin, neomycin, kanamycin and streptomycin). However, the results from PCR analysis showed that parC gene for ciprofloxacin resistance was only present in Lb. fermentum SMC2; vanX gene, responsible for the vancomycin resistance, was found in two strains Lb. plantarum AS34 and TJ26. Most strains showed susceptibilityto at least one type of protein synthesis inhibit antibiotics: chloramphenicol, erythromycin and clindamycin. Four strains Lb. brevis NCTH24, Lb. casei PK2, Lb. fermentum SBV2, and Lb. plantarum NCDC3 did not carry any antibiotic resistance genes which indicates these antibiotic resistances are intrinsic and nontransmissible.
Multicomponent reaction for the synthesis of novel fluorinated 2-amino-4H-benzo[g]chromene-5,10-dione-3-carbonitriles
Authors: Ha Thanh Nguyen , Phuong Hoang Thi , Giang Le Nhat Thuy , Quynh Giang Nguyen Thi , Tuan Anh Nguyen , Tuyet Anh Dang Thi , Tuyen Nguyen Van
Published: December 2023

Chromene is a significant class of heterocyclic compounds prossessing a simple structure as well as important biological activities. Many studies have been done to find new approaches for the preparation of chromene derivatives. Notably, the introduction of fluorine into heterocyclic molecules resulted in a significant improvement of their biological activities. In this study, a simple, straightforward, and highly efficient microwave-assisted three-component synthesis of novel 2-amino-4H-benzo[g]chromene-5,10-dione-3-carbonitrile derivatives bearing fluorine atoms has been developed using 1,4-diazabicyclo[2.2.2]octane (DABCO) as an eco-friendly catalyst, and acetonitrile as a solvent. Starting from 2-hydroxy-1,4-dihydronaphthalene-1,4-dione, malononitrile, and fluorinated aromatic aldehyde, 2-amino-4H-benzo[g]chromene-5,10-dione-3-carbonitrile derivatives have been afforded in good yields (71 – 76 %). The plausible reaction mechanism was described. Products were synthesized through a sequential Knoevenagel condensation, Michael addition, intramolecular cyclization, and [1,3]-hydrogen shift step. The structure of products was completely elucidated  by 1H NMR, 13C NMR, and mass spectra. The particularly valuable feature of this process is mild reaction conditions, short reaction times, and good yields.
Eco-friendly method of biocementation for soil improvement and environmental remediation in the context of Viet Nam: a state-of-the-art review
Authors: Nguyen Ngoc Tri Huynh , Nguyen Pham Huong Huyen , Nguyen Hoang Thien Khoi , Nguyen Khanh Son
Published: December 2023

Scientists have been using microorganisms to improve soil strength and durability through a process called biocementation. This technique involves inducing mineral precipitation to form a cement-like material that enhances soil properties. Biocementation has been successful in various applications, including soil stabilization, erosion control, and groundwater remediation. Researchers are optimizing nutrient concentrations and ratios to create a favorable environment for microbial activity and promote efficient mineral formation. Different microorganisms have varying abilities to induce mineralization, and cycle treatments have shown promise in stimulating biomineralization processes. Biocementation is a sustainable and eco-friendly technique that can stabilize and immobilize contaminants in soil and groundwater, preventing the spread of pollutants. Despite these challenges, biocementation holds great potential for innovative soil improvement and environmental remediation. Recent studies, experiments, testing devices, and results from research groups in the world and Vietnam in recent years were reviewed to gain insight into this promising approach. Ongoing research aims to develop cost-efficient and sustainable methods for large-scale production and application of biocementing agents. Further research is needed to uncover the intricate mechanisms and identify optimal strategies for applications and environmental conditions.
METHODS OF ASSESSING THE TECHNICAL CONDITION ARTIFICIAL STRUCTURES ON NARROW-GAUGE RAILWAY
Authors: V. Marochka  , О. Marochka  , V. Jurbenko  , Т. Lukhenko  , А. Poznyakov
Published: December 2023

Purpose. Analysis of the existing structures on the narrow-gauge railways, the research experience of of exploitation of these facilities on the narrow-gauge railways and the development of methodology for assessing the technical condition of the infrastructure of narrow gauge railways in accordance the existing norms. Methodology. Implementation of the expert group inspections and surveys path elements and passenger infrastructure and rolling stock and ancillary industries involved in the operation of the narrow-gauge railway and the assessment of the overall technical condition of the railway track and structures plot narrow-gauge railway in the Carpathian region. Findings. The authors of this study developed a method for assessing the technical condition of infrastructure of narrow gauge railways, which solves most of the issues of operating structures of narrow-gauge railways. Originality. Analysis of existing standards for narrow-gauge railways was held. Surveying of the infrastructure of railways were performed. With this in one normative document it became possible to collect almost all of the basic requirements for the structure and the way to the narrow-gauge railways, it is necessary at the time of the survey, assessing the technical condition and the design, construction and operation of these structures. Practical value. Developed «Methodology to evaluate the technical condition of the infrastructure Narrow Gauge Railway» is the basis for establishing a modern system of operating facilities and the track on the narrow-gauge railways.
OPTIMIZATION OF GEOMETRICAL PARAMETERS OF RUNNING TUNNELS SUPPORT ON THE BASIS OF THE METROGIPROTRANS MODIFIED METHOD
Authors: O. Тiutkin  , М. Umanskaya
Published: December 2023

Purpose. Applying the Metrogiprotrans modified method it is necessary to correct the developed models so that in subsequent their application gave results which answer of the real conduct of tunnel support at cooperation with a surrounding array. This research allows to execute the scientific ground of the diminished thickness of frame with the receipt of considerable economic effect.  Methodology. For the decision of optimization task of running tunnels support geometrical parameters of the Metrogiprotrans method which is modified in accordance with bases of finite elements method is applied. On the basis of the got moments and normal forces the calculation of reinforced concrete elements are executed, the graph is built and dependence of bending moments and normal forces from the thickness of reinforced concrete element is set. Findings. The executed calculations were proved, that the terms of durability are executed for three variants, that diminishment of support thickness does not result in diminishment of block durability, that is explained by possibility of large deformations development toward soil for more pliable support. Development of greater resilient rebuff acts positive part in forming of power factors, here diminishment of amount of armature bars is an important factor, which considerably decreases expenses. Possibility of application of Variant 3 (thickness of element – 15 centimeter, amount of armature bars – 12 things) with the coefficient of the supply 1,6 is most optimum for certain basic data’s of the represented work. Thus, the got results of research give possibility of receipt of bending moments and normal forces dependences from the thickness of reinforced concrete element and ground of running tunnels support geometrical parameters of the Dnepropetrovsk Metro, however needs the considerable complex of researches for the cases of other engineering and geological terms and change of support material. The complete complex of researches puts by a purpose the receipt of the scientifically grounded results which will allow to reduce material charges at building of the Dnepropetrovsk Metro and accordingly economize considerable money facilities. Originality. The collected dependence of bending moments and normal forces from the thickness of reinforced concrete element, which allows for certain soil to execute optimization of running tunnels support geometrical parameters. Practical value. The approaches on decreasing material expenses at building of the Dnepropetrovsk Metro are offered.
Relationship Between the Tax Burden Structure and Citizens’ Welfare in OECD Countries
Authors:   P.G. Demidov Yаroslavl State University, Yаroslavl, Russian Federation, Pugachev A. A.
Published: December 2023

This research aims to examine the correlation between the tax burden structure and citizens’ welfare in OECD countries in 2020 and 2021. The hypothesis tested suggests an interconnection between the tax burden structure and citizen welfare, particularly a direct relationship between the income tax share and welfare, and an inverse relationship between the share of indirect taxes and welfare. The study employs correlation-regression, cluster, and structural analysis methods, along with data from OECD.Stat and the World Bank. The calculations were performed by using the “Data Analysis” package in MS Excel for the years 2000, 2018–2019, and 2021. The resulting dataset, comprising 1,540 indicators of welfare and tax burden structure across 38 OECD countries, confirmed a significant connection between the two. The income tax share exhibited the most pronounced unidirectional relationship with welfare, while the share of indirect taxes showed a negative correlation. Conversely, the share of the corporate income tax, property taxes, and social security contributions displayed non-significant correlations with welfare levels. To further categorize OECD countries, the k-means method and the DATAtab web tool were employed based on the parameters of the relationship between welfare and the tax burden structure. In high-income OECD countries, the income tax share averages 37.6%, with indirect taxes comprising 24.1% while in lower-income countries the share of the income tax is 6–20% (average 14.8%), with indirect taxes comprising 35–53% (average 39.7%) of the tax burden. To foster the growth of citizens’ welfare in Russia, it is advisable to increase the share of the income tax by enhancing the progressivity of its scale for the super-rich while maintaining the share of indirect taxes at the pre-crisis average level (≈25%).
Asymmetry Effect of Tax and Public Debt on Private Consumption Spending in Russia
Authors:   Pandit Deendayal Energy University, Gandhinagar, India, Mehta Dhyani , Derbeneva Valentina V. ,   Ural Federal University named the first President of Russia B.N. Yeltsin, Yekaterinburg, Russian Federation
Published: December 2023

According to the Ricardian Equivalence theory, private consumption spending is unaffected by the debt vs tax mode of deficit financing. The study re-examines the “Ricardian Equivalence” hypothesis in Russia by using private consumption spending as the dependent variable and government expenditure, government borrowing, tax, and income as the independent variables. The Ricardian position offers an intriguing issue in the Russian setting. If the Russian economy exhibits Ricardian equivalence, the private sector will shift its spending habits and boost its savings, rendering the policy reforms ineffectual. The ARDL and NARDL models used yearly time series data between 1988 and 2022. The results refute the Ricardian Equivalence and support the Keynesian perspective that financing the fiscal deficit (debt vs tax) does affect private consumption spending. The estimates support a strong long-run and short-run link between the variables. Estimates confirm that tax and borrowing mode of deficit financing negatively influences Russia’s consumption spending. It shows that short-run disequilibrium converges to long-run equilibrium in the ARDL model at a rate of 85.3% and in the NARDL model at a rate of 28.6%. The study concludes that the deficit financing strategy should be carefully devised and supported. Implementing an expansionary fiscal policy will influence the overall private demand of Russia. A tendency to rely too much on tax and borrowings as a financing technique negatively influences private consumption spending. This study contributes to the pool of literature on “Ricardian Equivalence” and deficit financing by providing new data on how to formulate fiscal policies that are efficient at financing deficits and sustainable by making prudent expenditures without endangering the nation’s private consumption.
Association Between Dysmobility Syndrome with Serum Vitamin D in Community-Dwelling Older Adults
Authors: Kong Ji-Young , Lee Inhwan
Published: December 2023

PURPOSE: To investigate the association between serum vitamin D levels and dysmobility syndrome (DMS) in community-dwelling older adults.METHODS: This cross-sectional study included 390 older adults (80.7% female) with a mean (±SD) age of 74.8±5.5 years. Based on high body fat level, osteoporosis, low muscle mass, slow gait speed, low grip strength, and fall(s), participants were classified as robust, pre-DMS, or DMS. Based on serum vitamin D levels, subjects were classified as high 33%, middle 33%, and lower 33%, and/or ≥20 ng/mL and <20 ng/mL, respectively. Logistic regression analyses were performed to determine odds ratios (OR) for serum vitamin D levels in DMS.RESULTS: There were linear increases in DMS variables such as high body fat (p = .040), slow gait speed (p = .048), fall(s) (p = .005), and prevalence of DMS (p = .001) across decremental serum vitamin D levels. Compared with the high vitamin D group (as reference), the low 33% group exhibited a higher OR for DMS (OR 2.776, p = .02). Similarly, compared with the vitamin D ≥20 ng/mL group (as reference), the <20 ng/mL group had a higher OR for DMS (OR 2.486, p = .002).CONCLUSIONS: Findings of this study suggest higher serum vitamin D levels through promoting outdoor physical activity and a healthy diet are key components protecting older adults against DMS.
Melatonin as an Antioxidant Supplement in Athletes: A Literature Review of Current Evidence
Authors: Kim Taewan , Cho Jinkyung
Published: December 2023

PURPOSE: Melatonin (MT; N-acetyl-5-methoxytryptamine) is synthesized and released during the night in specialized pineal gland cells. Among its variety of physiological properties, recent research indicates that MT has both antioxidant and anti-inflammatory actions. The aim of this literature review was to summarize recent evidence that describes the effects of MT on the muscle function and preventive role of MT on exercise-induced muscle damage.METHODS: This review included previous research using the PubMed, Science Direct, and Google Scholar databases.RESULTS: We discussed the molecular structure and biological function of MT and the potential role of this hormone in antioxidant and anti-inflammatory processes. These activities have been studied in relation to the protection of muscle function against oxidative damage. In addition, MT is reported to have positive effects on muscle damage, lipid metabolism, and inflammatory responses in well-trained athletes following exercise training. Moreover, the potential beneficial effects of melatonin and mechanisms related to performance were revealed through improved sleep quality, muscle damage, and antioxidant levels in trained athletes.CONCLUSIONS: Finally, this review suggested that possibilities of MT as a supplementation for athletes; however, further research is required to investigate the specific mechanisms involved, the dose and duration of use, and the beneficial and detrimental effects of MT on athletic performance.
Effects of Lifelong Aerobic Exercise on Ferroptosis-Related Gene Expressions in Kidney of Aged Mice
Authors: Xiang Ying-Ying , Baek Kyung-Wan , Won Jong-Hwa , Park Yoonjung , Kim Ji-Seok
Published: December 2023

PURPOSE: This study sought to explore the impact of continuous aerobic exercise throughout life on the expression of ferroptosis-related genes in aging kidneys, elucidating the role of exercise in maintaining kidney health.METHODS: Male C57BL/6 mice were divided into young control, young exercise, old control, and old exercise groups, with the latter providing access to spontaneous running wheels. Aged mice were observed until 99 weeks, while young mice were followed until 22 weeks. Kidney tissue samples underwent analysis through quantitative polymerase chain reaction, iron assays, histological staining, and pathological damage scoring.RESULTS: Expression of Nphs1 and Nphs2 exhibited no significant changes after exercise. However, histological analysis revealed that age-related kidney damage, including glomerular mesangial proliferation, was notably offset by lifelong aerobic exercise. The expression of Slc7a11 and Gpx4 remained unaffected by exercise, whereas Nfe2l2 expression decreased significantly in the young exercise groups. Acsl4 expression exhibited no aging- or exercise-induced differences. Additionally, Tfrc expression was lower in the young exercise group than in the young control group but remained consistent between the old and old-exercise groups. Total iron (Fe) increased in aged mice compared to that in the young-exercise group, and the Fe2+/Total Fe ratio was lower in the old-exercise than in the old control group.CONCLUSIONS: Lifelong aerobic exercise positively impacted kidney health by enhancing antioxidant capacity and mitigating iron accumulation. These findings underscore the significance of exercise in preventing age-related deterioration in kidney function.
When McCloskey meets Latour: changing the perspectives on the debates about Rhetoric in Economics
Authors: PIRES MAYARA S. S. , FERNÁNDEZ RAMÓN G.
Published: December 2023

ABSTRACT This paper rescues Deirdre McCloskey’s ideas about Rhetoric in Economics and some issues left out in subsequent discussions. There is a parallel between the ideas of McCloskey and Bruno Latour, and the complementarities of their perspectives are very relevant for the development of Economics. Some reflections are here offered to improve the practice of Economics, which are related to the social constructions of facts in the field, to the internalization of political aspects, and to the importance of alternating between fact and fiction in a dynamic that does not result in a zero-sum game, underlining the characteristic of Economics as being inherently rhetorical.
Do homem medieval ao liberal: ciclos e crises do liberalismo - tendências autoritárias recentes
Authors: SILVA LUIZ AFONSO SIMOENS DA
Published: December 2023

RESUMO O estudo começa coletando evidências relativas a eventuais ciclos de regulação/desregulação entre as décadas iniciais do séculos XX e XXI. Depois, analisa a passagem do Homem Medieval para o Homem Liberal na Europa, onde foca no impacto econômico e político desses eventos desde o Liberalismo Clássico até o Neoliberalismo. Segue-se uma busca de respostas para o atual quadro de desarranjos e tendências autoritárias no mundo derivadas, em essência, do Neoliberalismo dominante e especulações são feitas acerca do futuro desse sistema.
PROFISSÃO DOCENTE E FORMAÇÃO DE PROFESSORES/AS PARA A EDUCAÇÃO BÁSICA: REFLEXÕES E REFERENCIAIS TEÓRICOS
Authors: LOMBA MARIA LÚCIA DE RESENDE , SCHUCHTER LÚCIA HELENA
Published: December 2023

RESUMO: Este artigo objetiva apresentar, numa perspectiva histórica e reflexiva, conceitos e referenciais teóricos sobre docência e formação de professores/as na educação básica, destacando seus desafios. Trata-se de uma pesquisa bibliográfica que apresenta uma diversidade epistemológica acerca dos temas docência e formação de professores/as ancorada em autores como Nóvoa (1995; 1999; 2009; 2017; 2019); Gatti (2020; 2021); Gatti et al. (2019); Freire (2005); e Teixeira (2007), entre outros. O corpo deste texto tem como materialidade o recorte de duas teses de doutorado (LOMBA, 2020; SCHUCHTER, 2017); artigos de periódicos, entrevistas e capítulos de livros. O estudo aponta a necessidade de engajamento por parte dos/as professores/as em seus percursos formativos e no exercício de sua profissão, no que tange a pensar estratégias e possibilidades para as novas demandas impostas à educação que perpassam a sociedade, a vida escolar e a formação profissional. Docentes e seus pares, coletivamente, podem grassar conquistas e rupturas com modelos educacionais ineficientes, promovendo condições mais favoráveis ao trabalho e ações para as mudanças necessárias na busca por uma educação de qualidade. Sugere-se que as políticas públicas de formação são um direito, uma necessidade e uma corresponsabilidade de docentes e instituições educacionais. Espera-se que professores/as analisem, compreendam e intervenham consciente e criticamente em sua realidade, em sua profissão e em sua formação, visando à transformação social.
DEVELOPMENT OF ADENOCARCINOMA AFTER RADIOFREQUENCY ABLATION OF BARRETT’S ESOPHAGUS ASSOCIATED TO FUNDOPLICATION AND SUPPRESSION-DUODENAL DIVERSION PROCEDURE: A LESSON TO BE LEARNED
Authors: Braghetto Italo
Published: December 2023

ABSTRACT Despite endoscopic eradication therapy being an effective and durable treatment for Barrett’s esophagus-related neoplasia, even after achieving initial successful eradication, these patients remain at risk of recurrence and require ongoing routine examinations. Failure of radiofrequency ablation and argon plasma coagulation is reported in 10–20% of cases.
Mushrooms to live or die: toxicity of some Basidiomycota using Artemia franciscana
Authors: Ruiz-González L. E. , Guzmán-Dávalos L. , Guerrero-Galván S. R. , Vega-Villasante F.
Published: December 2023

Abstract Consumption of wild mushrooms has increased in recent years; however, not all of them are edible and there is no precise information on those that may cause poisoning. Therefore, studies to obtain data about their toxicity are needed. For this purpose, we used the brine shrimp Artemia franciscana, a crustacean employed in toxicity tests and with wide application in the toxin detection, including mycotoxins. Mushrooms were collected in the state of Jalisco, Mexico, with which aqueous extracts were prepared. Dilutions of the stock solution of each extract were made to final concentrations of 50, 100, 250, 500, and 1000 µg/mL. Potassium dichromate (PD) was used as positive control and artificial seawater as negative control. The median lethal dose (LD50) of extracts on nauplii of A. franciscana was calculated. The aqueous extracts obtained from Amanita amerivirosa, A. muscaria, Chlorophyllum molybdites, and Leucopaxillus amarus showed a LD50 < 70 µg/mL, similar to PD (LD50 = 37 µg/mL). This is the first indication of the probable toxicity of Leucopaxillus amarus in humans. Cantharellus cibarius and Scleroderma texense caused the lower toxicity to the nauplii. The brine shrimp bioassay was effective in evaluating the toxicity of Basidiomycota. Scleroderma texense has been reported to be toxic, but it was not for this crustacean nauplii, and probably not to humans either, as recent literature has reported.
Flight radius and climatic conditions affect the external activity of stingless bee Melipona rufiventris (Lepeletier, 1836)
Authors: Freitas P. V. D. X. , Faquinello P. , Arnhold E. , Ferro D. A. C. , Ferro R. A. C. , Lacerda M. L. G. , Leite P. R. S. C. , Silva Neto C. M.
Published: December 2023

Abstract The objective of this study was to verify the flight radius and the influence of the climatic season and period of the day on the external activity of Melipona rufiventris bees. The forager bees were released at different distances to evaluate the flight radius. The following were considered for external activities in the four different seasons of the year (Winter, Autumn, Spring, Summer): the entry with no apparent load was considered as nectar/water, entry with defined and opaque mass in the corbicula was considered as pollen, the entry with undefined and shiny mass in the corbicula was considered as resin/clay or bee exit no load and removal of debris, mass trapped by the jaws. Assessments were performed between 6 am and 6 pm each month. M. rufiventris can reach distances of 2 500 meters, however the return decreases as the distance increases. The species performs all activities in and out of the colony during all seasons of the year and periods between 6 am and 6 pm but reduce nectar/water collection and exit from the box without apparent load and with debris between 6:00 am and 10 am in winter. It is concluded that distances greater than 1 500 meters hinder the external activity of bees which is influenced by air temperature, air humidity, time of day, season of the year and food availability.
Impacts of an urban flood control infrastructure on the limnology and ichthyofauna of a basaltic Cuesta stream (southeast Brazil)
Authors: Siva L. A. , Kimura R. S. Y. , Brambilla E. M. , Silva S. O. , Nogueira M. G.
Published: December 2023

Abstract Strategies for flood control associated to extreme precipitation events in urban areas are urgent, in order to prevent not only material damages but also to avoid human losses. The construction of flood contention reservoirs (“piscinões”) has become a common engineering intervention in urban and peri-urban areas. However, there is a lack of studies focused on the evaluation of environmental impacts of this type of construction. This study intended to verify the ecological effects of a retention reservoir built directly on the course of the Cascata stream, Botucatu (SP). Three sampling sites were selected, located upstream the reservoir, in the reservoir and downstream. Samplings were carried out in July (winter - dry) and November (late spring - rainy) 2020. In situ measurements were obtained through a multiparameter probe (temperature, pH, electrical conductivity, dissolved oxygen, total dissolved solids, and oxidation-reduction potential) and water samples were collected for laboratory determinations (nitrogen, total phosphorus, thermotolerant coliforms, and chlorophyll-a). For fish sampling, manual trawls, sieves and hand nets were used, with a sampling effort of 10 throws per artefact and site. Despite the small distance between the sampling points (~1,300 m) considerable changes in the limnological conditions and fish community structure were observed. The studied environment is originally a small river surrounded by riparian forest, but this characteristic was abruptly changed in the reservoir stretch, with the direct exposition of a much larger water surface to intense solar radiation and atmosphere exchanges. Consequently, as evidenced by the PCA analysis, there was a considerable (stream-reservoir increase) of temperature, dissolved oxygen and chlorophyll. However, this spatial trend was partially disturbed by an accidental sewage-pipe rupture (posteriorly fixed) adjacent to the first sampling point, due to a previous event of extreme precipitation, which resulted in increased values of nutrients, chlorophyll, conductivity and thermotolerant coliforms. Eleven fish species were collected (two non-native), belonging to seven families and five orders. The upstream reference point (despite not be pristine), was characterized by the predominance of native species, while the reservoir condition favored the development of large populations of the non-native species. Despite the urgency of effective actions to prevent floods in urban areas, construction of contention reservoirs directly on stream courses should be avoided, due to their negative ecological impacts.
THE PUBLIC HEALTHCARE FINANCING POLICY IN BRAZIL: CHALLENGES FOR THE POST-PANDEMIC FUTURE
Authors: Guidolin Ana Paula , David Grazielle , Rossi Pedro Linhares
Published: December 2023

ABSTRACT Healthcare financing is attracting widespread interest due to the coronavirus pandemic. This study aims to assess federal public healthcare financing in Brazil in the light of a legal framework for minimum spending on health and the effects of economic cycles and crises. A literature review showed that public healthcare funding should increase during crises, which is contrary to what fiscal austerity policies postulate. Different formats of fiscal rules for minimum spending on health are analyzed based on the historical evolution of healthcare financing in Brazil. A simulation shows that linking this spending rule to GDP (and especially to current revenue) gives a pro-cyclical character to healthcare financing, which can make it difficult to guarantee health rights in times of crisis. Thus, a debate arises about the need to revise the rule set by the Constitutional Amendment 95/2016 (EC no. 95/2016) and to establish a parameter for growth in public healthcare expenditure that eliminates its pro-cyclical characteristic and enables the needs of the country to be met after the pandemic.
Atuação da Psicologia em Unidade Neonatal no Contexto da Pandemia da Covid-19
Authors: Domingues Sarah Marques , Melo Eleonora Pereira
Published: December 2023

Resumo A pandemia de covid-19 provocou intensas mudanças no contexto do cuidado neonatal, exigindo dos profissionais de saúde a reformulação de práticas e o desenvolvimento de novas estratégias para a manutenção da atenção integral e humanizada ao recém-nascido. O objetivo deste artigo é relatar a atuação da Psicologia nas Unidades Neonatais de um hospital público de Fortaleza (CE), Brasil, durante o período de distanciamento físico da pandemia de covid-19. Trata-se de estudo descritivo, do tipo relato de experiência, que ocorreu no período de março a agosto de 2020. No contexto pandêmico, o serviço de Psicologia desenvolveu novas condutas assistenciais para atender às demandas emergentes do momento, como: atendimento remoto; registro e envio on-line de imagens do recém-nascido a seus familiares; visitas virtuais; e reprodução de mensagens de áudio da família para o neonato. Apesar dos desafios encontrados, as ações contribuíram para a manutenção do cuidado centrado no recém-nascido e sua família, o que demonstra a potencialidade do fazer psicológico.
Notas Sobre o Pesquisar em Cena(s)
Authors: Wottrich Laura Anelise Faccio , Torossian Sandra Djambolakdjian
Published: December 2023

Resumo O presente artigo tem como objetivo apresentar a construção metodológica desenvolvida em uma pesquisa de mestrado, na qual sustentamos a escrita de cenas como método de pesquisa da escuta clínica. As cenas do trabalho em questão foram recolhidas ao longo do tempo, no contorno da experiência de um projeto de extensão universitária de atenção à infância e adolescência em situação de vulnerabilidade social, situado em uma comunidade periférica. Apresentamos, neste texto, as interrogações que se elaboraram em torno da escolha pelo trabalho com cenas, e compartilhamos o resgate histórico dessas como um método de escrever a clínica, bem como a retomada de sua análise a partir da tradição psicanalítica. Amparadas nesta teoria e em leituras e contribuições do filósofo francês Jacques Derrida, embasamos a noção de que a cena se constitui como um lugar de produção, ao engendrar a configuração particular de elementos significantes nos processos de subjetivação e de construção social. A cena não é, então, compreendida aqui como uma representação do que acontece na clínica, mas como um modo de produzir a escuta e os seus processos de investigação.