bluuebunny/crossref_metadata_2025 huggingface dataset:
BookGPT: A General Framework for Book Recommendation Empowered by Large Language Model
Authors: Li Zhiyu , Chen Yanfang , Zhang Xuan , Liang Xun
Published: November 2023

With the continuous development and change exhibited by large language model (LLM) technology, represented by generative pretrained transformers (GPTs), many classic scenarios in various fields have re-emerged with new opportunities. This paper takes ChatGPT as the modeling object, incorporates LLM technology into the typical book resource understanding and recommendation scenario for the first time, and puts it into practice. By building a ChatGPT-like book recommendation system (BookGPT) framework based on ChatGPT, this paper attempts to apply ChatGPT to recommendation modeling for three typical tasks: book rating recommendation, user rating recommendation, and the book summary recommendation; it also explores the feasibility of LLM technology in book recommendation scenarios. At the same time, based on different evaluation schemes for book recommendation tasks and the existing classic recommendation models, this paper discusses the advantages and disadvantages of the BookGPT in book recommendation scenarios and analyzes the opportunities and improvement directions for subsequent LLMs in these scenarios. The experimental research shows the following: (1) The BookGPT can achieve good recommendation results in existing classic book recommendation tasks. Especially in cases containing less information about the target object to be recommended, such as zero-shot or one-shot learning tasks, the performance of the BookGPT is close to or even better than that of the current classic book recommendation algorithms, and this method has great potential for improvement. (2) In text generation tasks such as book summary recommendation, the recommendation effect of the BookGPT model is better than that of the manual editing process of Douban Reading, and it can even perform personalized interpretable content recommendations based on readers’ attribute and identity information, making it more persuasive than interpretable one-size-fits-all recommendation models. Finally, we have open-sourced the relevant datasets and experimental codes, hoping that the exploratory program proposed in this paper can inspire the development of more LLMs to expand their applications and theoretical research prospects in the field of book recommendation and general recommendation tasks.
Learing Sampling and Reconstruction Using Bregman Iteration for CS-MRI
Authors: Fei Tiancheng , Feng Xiangchu
Published: November 2023

The purpose of compressed sensing magnetic resonance imaging (CS-MRI) is to reconstruct clear images using data from the Nyquist sampling space. By reducing the amount of sampling, MR imaging can be accelerated, thereby improving the efficiency of device data collection and increasing patient throughput. The two basic challenges in CS-MRI are designing sparse sampling masks and designing effective reconstruction algorithms. In order to be consistent with the analysis conclusion of CS theory, we propose a bi-level optimization model to optimize the sampling mask and the reconstruction network at the same time under the constraints of data terms. The proposed sampling sub-network is based on an additive gradient strategy. In our reconstructed subnet, we design a phase deep unfolding network based on the Bregman iterative algorithm to find the solution of constrained problems by solving a series of unconstrained problems. Experiments on two widely used MRI datasets show that our proposed model yields sub-sampling patterns and reconstruction models customized for training data, achieving state-of-the-art results in terms of quantitative metrics and visual quality.
LiDAR Localization by Removing Moveable Objects
Authors: Jeong Seonghark , Ko Minseok , Kim Jungha
Published: November 2023

In this study, we propose reliable Light Detection and Ranging (LiDAR) mapping and localization via the removal of moveable objects, which can cause noise for autonomous driving vehicles based on the Normal Distributions Transform (NDT). LiDAR measures the distances to objects such as parked and moving cars and objects on the road, calculating the time of flight required for the sensor’s beam to reflect off an object and return to the system. The proposed localization system uses LiDAR to implement mapping and matching for the surroundings of an autonomous vehicle. This localization is applied to an autonomous vehicle, a mid-size Sports Utility Vehicle (SUV) that has a 64-channel Velodyne sensor, detecting moveable objects via modified DeepLabV3 and semantic segmentation. LiDAR and vision sensors are popular perception sensors, but vision sensors have a weakness that does not allow for an object to be detected accurately under special circumstances, such as at night or when there is a backlight in daylight. Even if LiDAR is more expensive than other detecting sensors, LiDAR can more reliably and accurately sense an object with the right depth because a LiDAR sensor estimates an object’s distance using the time of flight required for the LiDAR sensor’s beam to detect the object and return to the system. The cost of a LiDAR product will decrease dramatically in the case of skyrocketing demand for LiDAR in the industrial areas of autonomous vehicles, humanoid robots, service robots, and unmanned drones. As a result, this study develops a precise application of LiDAR localization for a mid-size SUV, which gives the best performance with respect to acquiring an object’s information and contributing to the appropriate, timely control of the mid-size SUV. We suggest mapping and localization using only LiDAR, without support from any other sensors, such as a Global Positioning System (GPS) or an Inertial Measurement Unit (IMU) sensor; using only a LiDAR sensor will be beneficial for cost competitiveness and reliability. With the powerful modified DeepLabV3, which is faster and more accurate, we identify and remove a moveable object through semantic segmentation. The improvement rate of the mapping and matching performance of our proposed NDT, by removing the moveable objects, was approximately 12% in terms of the Root-Mean-Square Error (RMSE) for the first fifth of the test course, where there were fewer parked cars and more moving cars.
Employing Spent Frying Oil as a Feedstock to Produce Short-Chain Organic Acids Using Mixed Microbial Cultures
Authors: Oliveira André , Petronilho Sílvia , Serafim Luísa S.
Published: November 2023

Food industry waste and wastewater have been explored in relation to acidogenic fermentation as sources of non-competing food carbohydrates and mixed microbial cultures (MMCs), respectively, with the aim of producing short-chain organic acids (SCOAs) with general applications in polyhydroxyalkanoates (PHAs) production. However, studies on acidogenic fermentation using lipidic substrates are scarce. In this work, it was hypothesized that spent frying oil (SFO) could be used as a substrate for SCOA production via MMCs. In this study, oleic acid was used as a model molecule. The characterization of SFO revealed that it is mainly composed of oleic acid (81%), with minor amounts of palmitic, linoleic, and stearic acids. Different MMCs and food-to-microorganism (F/M) ratios were tested. MMCs collected in the aerobic tank of a municipal wastewater treatment plant (AES), at a 1:1 F/M, allowed to obtain the highest SCOA concentration (1.50 g COD/L) and the most diverse profile of SCOAs, with the production of acetic, propionic, butyric, iso-butyric, and valeric acids at 48:17:9:13:13% on a molar basis, respectively. This variety of odd and even SCOAs is of upmost importance, with potential applications in producing PHAs. This work can be considered a starting point for future acidogenic fermentation studies using lipid-based substrates and for the future production of PHAs.
Denoising of Images for Temperature and Chemiluminescence Measurements of Premixed Flames Applying the Abel Transform
Authors: Zamarripa-Ramírez J. C. I. , Moreno-Hernández D. , Martinez Gonzalez A.
Published: November 2023

The temperature field and chemiluminescence measurements of axisymmetric flame are obtained simultaneously in only one image. Digital Laser Speckle Displacement measures temperature fields, and direct image flame determines chemiluminescence values. Applying the Abel transform of axisymmetric objects for volume visualization requires smooth intensity profiles. Due to the nature of the experimental setup, direct image flame is corrupted with speckle noise and a crosstalk effect. These undesirable effects deteriorate the measurement results. Then, experimental data need crosstalk correction and speckle noise reduction to improve the measurements. This work aims to implement a methodology to reduce the speckle noise of highly noisy data intensity profiles to create smooth profiles appropriate to applying the Abel transform. The method uses a Four-Order Partial Differential Equation to reduce speckle noise and a Curve fitting utilizing a set of Gaussian functions to decrease residual undesirable effects. After this, correction of crosstalk is necessary to avoid this effect. The methodology is applied to premixed flames generated with Liquid Petroleum Gas for different mixes.
Numerical Simulation of Dropwise Condensation of Steam over Hybrid Surfaces via New Non-Dimensional Heat Transfer Model
Authors: Croce Giulio , Suzzi Nicola
Published: November 2023

Dropwise condensation (DWC) of steam over hybrid hydrophobic–hydrophilic surfaces is numerically investigated via a phenomenological, Lagrangian model. The full non-dimensionalization of the heat transfer model, needed to determine the droplet growth, allows for generalization of computational results. Hybrid surfaces characterized by recursive geometries are implemented via the introduction of proper boundary conditions. The numerical size distribution of both the large and the small droplet populations, crucial for development of simplified, statistically sound models, is compared with empirical and theoretical correlations. Then, the validation with experimental data involving DWC over an hybrid surface is successfully conducted and the heat flux is enhanced under different operating conditions via hybrid geometry optimization.
Hepatoprotective Effect of Tea Composite Solid Beverage on Alcohol-Caused Rat Liver Injury
Authors: Tang Zheng , Zhan Li , He Ranran , Zhou Yufei , Tang Quanquan , Liu Zhonghua , Zhang Sheng , Liu Ailing
Published: November 2023

Alcoholic liver disease (ALD) remains a major cause of liver-related morbidity and mortality worldwide. Tea polyphenols (TPs) possess strong antioxidant activity; cassia seed extract (CSE) has the effect of brightening the eyes; and Ampelopsis grossedentata extract (AGE) has the function of protecting the liver. However, the synergistic hepatoprotective effect of TP, AGE and CSE as a joint formulation is unknown. This study aimed to investigate the role of a tea solid beverage, composed of TP, AGE and CSE, on chronic alcoholic liver injury in rats and its underlying mechanisms via the analysis of transcriptomics and gut microbiota. The histopathological findings revealed that the tea solid beverage could reduce the production of fat vacuoles and inflammatory cell infiltration. Additionally, the tea solid beverage was found to effectively relieve the increase in the AST (from 424.85 U/L to 180.17 U/L), ALT (from 139.95 U/L to 85.88 U/L) and LDH (from 21.16 U/L to 13.35 U/L) enzyme activities and the expression of the inflammatory factors TNF-α (from 394.02 pg/mL to 214.44 pg/mL) and IL-6 (from 208.46 pg/mL to 116.59 pg/mL) caused by alcohol consumption. Further, it significantly enhanced the GSH concentration (from 4.53 pg/mL to 8.08 pg/mL) and SOD activity (from 84.70 U/mL to 156.94 U/mL) and decreased the MDA (from 58.61 mmol/mL to 36.58 mmol/mL) and TG (from 7.07 mmol/L to 3.43 mmol/L)) concentrations in the liver of rats. The analysis and identification of transcriptomics showed that the tea solid beverage intervention primarily protected the liver of rats with chronic alcoholic injury by up-regulating the differential gene Hmgcs1 in order to increase the synthesis of ketone bodies and by down-regulating the differential gene Pfkfb1 for the purpose of decreasing the glucose metabolism. Additionally, it was found that the tea solid beverage could significantly change the composition of intestinal flora in drinking rats by regulating mineral absorption, the pathways of bile secretion, the adipocytokine signaling pathway and the peroxisome balance of the intestinal flora, in order to protect alcohol-drinking rats’ livers. In conclusion, the tea solid beverage, consisting of TP, AGE and CSE, is a functional drink that prevents ketone metabolism, glucose metabolism and microbiome disorders induced by alcohol intake.
Investigating the Chemical Composition of Lepidium sativum Seeds and Their Ability to Safeguard against Monosodium Glutamate-Induced Hepatic Dysfunction
Authors: El-Gendy Manal Salah , El-Gezawy Eman Sobhy , Saleh Ahmed A. , Alhotan Rashed A. , Al-Badwi Mohammed A. A. , Hussein Elsayed Osman Sewlim , El-Tahan Hossam M. , Kim In Ho , Cho Sungbo , Omar Sara Mahmoud
Published: November 2023

Monosodium glutamate (MSG) is one of the most frequently used food additives that endanger public health. The antioxidant, hyperlipidemic, and cytoprotective properties of Lepidium sativum seeds (LSS) as a natural remedy can minimize the harmful effects of MSG. This study investigated the potential protective effect of LSS against MSG-induced hepatotoxicity in rats. Male albino Sprague Dawley rats (n = 24) were equally divided into four groups for 30 days: the control group (G1) received a basal diet without supplement, group (G2) was fed a basal diet + MSG (30 g/kg b.w.) as a model group, group (G3) was fed a basal diet + MSG (30 g/kg b.w.) + LSS (30 g/kg b.w.), and group (G4) was fed a basal diet + MSG (30 g/kg b.w.) + LSS (60 g/kg b.w.). LSS enhanced serum alkaline phosphatase activity as well as total cholesterol, triglyceride, and glucose levels. It can decrease peroxide content in serum lipids and inhibit glutathione reductase and superoxide dismutase in hepatic cells. The dietary supplementation with LSS provided cytoprotection by enhancing the histoarchitecture of the liver and decreasing the number of apoptotic cells. Due to their antioxidant and anti-apoptotic properties, LSS effectively protect against the hepatotoxicity of MSG. These findings are of the highest significance for drawing attention to incorporating LSS in our food industry and as a health treatment in traditional medicine to combat MSG-induced hepatic abnormalities.
Enhancing Solubility and Reducing Thermal Aggregation in Pea Proteins through Protein Glutaminase-Mediated Deamidation
Authors: Luo Lijuan , Deng Yuanyuan , Liu Guang , Zhou Pengfei , Zhao Zhihao , Li Ping , Zhang Mingwei
Published: November 2023

The limited solubility and stability of pea proteins hinder their utilization in liquid formulations. In this study, protein glutaminase (PG) was employed to modify pea protein isolates (PPIs) and obtain deamidated PPI with varying degrees of deamidation (DD, 10–25%). The solubility and thermal stability of these deamidated PPI samples were assessed, and a comprehensive analysis, including SDS-PAGE, zeta potential, FTIR, surface hydrophobicity, and intrinsic fluorescence, was conducted to elucidate the mechanism behind the improvement in their functional properties. The results reveal that PG modification greatly enhances the solubility and heat stability of PPI, with the most notable improvements observed at higher DD (>20%). PG modification increases the net charge of PPI, leading to the unfolding and extension of the protein structures, thus exposing more hydrophobic groups. These structural changes are particularly pronounced when DD exceeds 20%. This increased electrostatic repulsion between carboxyl groups would promote protein unfolding, enhancing interactions with water and hindering the aggregation of unfolded protein in the presence of salts at elevated temperatures (supported by high-performance size exclusion chromatography and transmission electron microscopy). Accordingly, PG-mediated deamidation shows promise in enhancing the functional properties of PPI.
Recent Advances in Non-Targeted Screening of Compounds in Plastic-Based/Paper-Based Food Contact Materials
Authors: Chen Ya , Li Hongyan , Huang Haizhi , Zhang Biao , Ye Zihong , Yu Xiaoping , Shentu Xuping
Published: November 2023

Ensuring the safety of food contact materials has become a pressing concern in recent times. However, detecting hazardous compounds in such materials can be a complex task, and traditional screening methods may not be sufficient. Non-targeted screening technologies can provide comprehensive information on all detectable compounds, thereby supporting the identification, detection, and risk assessment of food contact materials. Nonetheless, the non-targeted screening of food contact materials remains a challenging issue. This paper presents a detailed review of non-targeted screening technologies relying on high-resolution mass spectrometry for plastic-based and paper-based food contact materials over the past five years. Methods of extracting, separating, concentrating, and enriching compounds, as well as migration experiments related to non-targeted screening, are examined in detail. Furthermore, instruments and devices of high-resolution mass spectrometry used in non-targeted screening technologies for food contact materials are discussed and summarized. The research findings aim to provide a theoretical basis and practical reference for the risk management of food contact materials and the development of relevant regulations and standards.
Biodegradable Poly(butylene succinate) Laminate with Nanocellulose Interphase Layer for High-Barrier Packaging Film Application
Authors: Nabels-Sneiders Martins , Barkane Anda , Platnieks Oskars , Orlova Liga , Gaidukovs Sergejs
Published: November 2023

In response to rising concerns over the environmental and human health ramifications of polymers derived from petroleum, particularly in the food packaging industry, research has pivoted towards more sustainable materials. Poly(butylene succinate) (PBS), selected as the polymer matrix, stands out as one of the most promising bio-based and biodegradable polymers suitable for film blowing and lamination. A layered spray-coating technique was employed to apply 1, 5, 10, and 20 layers of nanofibrillated cellulose (NFC) between blown PBS films, creating a three-layer laminate structure. NFC sourced from minimally processed hemp stalk waste highlights the potential for minimizing environmental impact. The water vapor transmission rate (WVTR) of these films, a critical parameter for food packaging, was assessed in a controlled environment at 38 °C and 90% relative humidity over a period of two months. The integration of a single NFC layer, constituting 0.35% of the composite’s weight, was observed to significantly reduce the WVTR by up to 5.5-fold. It was noted that higher NFC layer counts above 10 reduced the adhesion within the laminate layers. Morphological assessments showed that the number of structural defects increased with a higher count of NFC layers. As the count of NFC layers increased, the optical transparency of the laminates dropped from approximately 65% to 25% in the visible light spectrum. Notably, by weight percent, NFC proved to be an effective barrier even without chemical modification. The developed laminates stand out as a viable, green option for food packaging, offering a sustainable and renewable solution.
Ginger Oil Nanoemulsion Formulation Augments Its Antiproliferative Effect in Ehrlich Solid Tumor Model
Authors: Alharbi Danah S. , Albalawi Shouq F. , Alghrid Sarah T. , Alhwity Basma S. , Qushawy Mona , Mortagi Yasmin , El-Sherbiny Mohamed , Prabahar Kousalya , Elsherbiny Nehal
Published: November 2023

Cancer is a disease that is characterized by uncontrolled cell proliferation. Breast cancer is the most prevalent cancer among women. Ginger oil is a natural cancer fighter and anti-oxidant. However, the minimal absorption of ginger oil from the gastrointestinal tract accounts for its limited medicinal efficacy. The present study was designed to evaluate the efficacy of a nanoemulsion preparation of ginger oil on its oral bioavailability and in vivo anti-cancer efficacy. Ginger oil nanoemulsion was prepared by a high-pressure homogenization technique using different surfactants (Tween 20, 40, and 80). The prepared formulations were evaluated for droplet size, polydispersity index (PDI), zeta potential (ZP), pH, viscosity, and stability by calculating the creaming index percentage. The best formulation was evaluated for shape by TEM. The antitumor activity of the best nano-formulation was determined in comparison with the free oil using the in vivo Ehrlich solid tumor (EST) model. The prepared ginger oil nanoemulsion formulations exhibited acceptable droplet size in the range from 56.67 ± 3.10 nm to 357.17 ± 3.62 nm. A PDI of less than 0.5 indicates the homogeneity of size distribution. The oil globules possessed a negative charge ranging from −12.33 ± 1.01 to −39.33 ± 0.96 mV. The pH and viscosity were in the acceptable range. The TEM image of the best formulation appeared to be spherical with a small size. The ginger oil nanoemulsion reduced in vivo tumor volume and weight, extended animals’ life span, and ameliorated liver and kidney function in EST-bearing mice. These effects were superior to using free ginger oil. Collectively, the present study demonstrated that the ginger oil nanoemulsion improved oral absorption with a subsequent enhancement of its anti-proliferative efficacy in vivo, suggesting a nano-formulation of ginger oil for better therapeutic outcomes in breast cancer patients.
The Emulsifying Properties, In Vitro Digestion Characteristics and Storage Stability of High-Pressure-Homogenization-Modified Dual-Protein-Based Emulsions
Authors: Wu Meishan , He Xiaoye , Feng Duo , Li Hu , Han Di , Li Qingye , Zhao Boya , Li Na , Liu Tianxin , Wang Jing
Published: November 2023

The droplet size, zeta potential, interface protein adsorption rate, physical stability and microrheological properties of high-pressure-homogenization (HPH)-modified, dual-protein-based whey–soy (whey protein isolate—soy protein isolate) emulsions containing different oil phase concentrations (5%, 10% and 15%; w/w) were compared in this paper. The in vitro digestion characteristics and storage stability of the dual-protein emulsions before and after HPH treatment were also explored. The results show that with an increase in the oil phase concentration, the droplet size and interface protein adsorption rate of the untreated dual-protein emulsions increased, while the absolute value of the zeta potential decreased. When the oil phase concentration was 10% (w/w), HPH treatment could significantly reduce the droplet size of the dual-protein emulsion, increase the interface protein adsorption rate, and improve the elasticity of the emulsion. Compared with other oil phase concentrations, the physical stability of the dual-protein emulsion containing a 10% (w/w) oil phase concentration was the best, so the in vitro digestion characteristics and storage stability of the emulsions were studied. Compared with the control group, the droplet size of the HPH-modified dual-protein emulsion was significantly reduced after gastrointestinal digestion, and the in vitro digestibility and release of free amino groups both significantly increased. The storage stability results show that the HPH-modified dual-protein emulsion showed good stability under different storage methods, and the storage stability of the steam-sterilized dual-protein emulsion stored at room temperature was the best. These results provide a theoretical basis for the development of new nutritional and healthy dual-protein liquid products.
Hand Trauma in Emergency Department Management in Older Adults ≥ 80 Years Old: A Twenty-Year Retrospective Analysis
Authors: Fulchignoni Camillo , Covino Marcello , Pietramala Silvia , Lopez Ivo , Merendi Gianfranco , De Matthaeis Andrea , Franceschi Francesco , Maccauro Giulio , Rocchi Lorenzo
Published: November 2023

The prevalence of hand injuries increases with age, with elderly patients being more prone to hand lesions due to a combination of factors, such as reduced bone density and muscle strength, impaired sensation, and cognitive impairment. Despite the high incidence of hand injuries in the elderly population, few studies have addressed the management and outcomes of hand lesions in this age group. This study aimed to analyze the characteristics and management of hand lesions in patients over 80 years old. The authors conducted a retrospective analysis of medical records of patients over 80 years old who reached their Emergency Department with hand lesions between 2001 and 2020. Data on demographics, injury characteristics, and management were collected and analyzed. A total of 991 patients with hand lesions were included in the study, with a mean age of 84.9 years. The most common causes of injuries were domestic accidents (32.6%) and traffic accidents (12.8%). The most frequent types of hand lesions were fractures (23.5%) and superficial wounds (20.5%). Overall, 23.4% underwent surgical treatment for their hand issue, and 22.1% had associated injuries, among which, the most common were head trauma and other bone fractures. In conclusion, hand lesions in patients over 80 years old are frequent and pose significant challenges in diagnosis and management. Particular attention should be paid to associated injuries and limit indications to surgery when strictly necessary.
Incidence and Risk Factors for Wound Revision after Surgical Treatment of Spinal Metastasis: A National Population-Based Study in South Korea
Authors: Lee Han-Dong , Jang Hae-Dong , Park Jin-Sung , Chung Nam-Su , Chung Hee-Woong , Jun Jin-Young , Han Kyungdo , Hong Jae-Young
Published: November 2023

Wound complications are commonly seen after surgeries for metastatic spine tumors. While numerous studies have pinpointed various risk factors, there is ongoing debate. Therefore, this study aimed to verify various factors that are still under debate utilizing the comprehensive Korean National Health Insurance Service database. We identified and retrospectively reviewed a cohort of 3001 patients who underwent one of five surgical treatments (corpectomy, decompression and instrumentation, instrumentation only, decompression only, and vertebroplasty) for newly diagnosed spinal metastasis between 2009 and 2017. A Cox regression analysis was performed to determine the risk factors. A total of 197 cases (6.6%) of wound revision were found. Only the surgical method and Charlson comorbidity index were significantly different between the group that underwent wound revision and the group that did not. Regarding surgical methods, the adjusted hazard ratios for decompression only, corpectomy, instrumentation and decompression, and instrumentation only were 1.3, 2.2, 2.2, and 2.4, with these ratios being compared to the vertebroplasty group (p for trend = 0.02). In this regard, based on a sizable South Korean cohort, both surgical methods and medical comorbidity were found to be associated with the wound revision rate among spinal surgery patients for spinal metastasis.
Influence of Nutritional Status and Physical Fitness on Cognitive Domains among Older Adults: A Cross-Sectional Study
Authors: Boquete-Pumar Carmen , Álvarez-Salvago Francisco , Martínez-Amat Antonio , Molina-García Cristina , De Diego-Moreno Manuel , Jiménez-García José Daniel
Published: November 2023

Background: The health issues presented by the aging population can result in reduced muscle mass, poorer physical function, and cognitive impairment. The goal of this study was to determine how nutritional status and physical fitness relate to cognitive impairment in older adults. Methods: A cross-sectional descriptive and analytical study involving 100 participants was carried out to analyze the impact of nutritional status and physical fitness on cognitive impairment. Nutritional status was assessed with the Eating Assessment Tool (EAT-10) and The Mini Nutritional Assessment—Short Form (MNA-SF); physical fitness via the implementation of manual grip evaluation, the 4-m walking test (4-MWT), and the Timed Up and Go (TUG) test; and cognitive impairment evaluation was conducted using the Mini-Mental State Examination (MMSE), the Boston Naming Test (BNT) and the Controlled Oral Word Association Test (COWAT). Results: Data analysis revealed that higher malnutrition status was associated with fewer correct responses in the COWAT (R2 = 0.421), while a correlation between higher MMSE and BNT scores, faster completion times for the 4-m walking and TUG tests, and an increase in handgrip strength load was also observed. Conclusion: The analysis of the data revealed that those individuals with superior nutritional status and greater levels of physical fitness outperformed others on the cognitive evaluation.
Adapting a Clinical Practice Guideline for Management of Patients with Knee and Hip Osteoarthritis by Hong Kong Physiotherapists
Authors: Al Zoubi Fadi M. , Wong Arnold Y. L. , Cheing Gladys L. Y. , Cheung Jason P. Y. , Fu Siu Ngor , Tsang Helen H. L. , Law Rainbow K. Y. , So Billy Chun Lung , Tsang Raymond , Tsang Sharon , Wen Chunyi , Wong Michael , Yau Yim Ching , Bussières André E.
Published: November 2023

Knee and hip osteoarthritis are common disabling conditions globally. Although numerous international clinical practice guidelines exist to guide physiotherapy management, not all recommendations issued from these guidelines can be translated to other contexts without considering the cultural acceptability and clinical implementability of targeted countries. Because the ADAPTE framework provides a robust methodology to adapt guidelines to the local context, this study used its methodology to adapt high-quality guideline recommendations to promote optimal physiotherapy care for knee and hip osteoarthritis in Hong Kong. The ADAPTE framework was used and modified to complete the adaptation process. International clinical practice guidelines were identified from eight guideline clearinghouses and six electronic databases. Two independent reviewers critically appraised the eligible guidelines using the AGREE II tool. We extracted and tabulated recommendations from high-quality guidelines. A voting-based consensus among interdisciplinary experts was conducted to decide on suitable recommendations for the Hong Kong context and whether there was a need to modify them. Pertinent recommendations were then translated into the traditional Chinese language. Our team members suggested modifying four tools and adding one to explore the patient’s feedback on the recommendations, to the ADAPTE framework. The adaptation was performed on three high-quality guidelines. We adapted 28 and 20 recommendations for treating knee and hip osteoarthritis, respectively. We recommend a multimodal treatment for managing knee and hip osteoarthritis. Land- and aquatic-based exercises, patient education, and self-management were strongly recommended for patients with knee osteoarthritis. Land- and aquatic-based exercises were strongly recommended for patients with hip osteoarthritis. This is the first adaptation study in Hong Kong. It provides guidance to local physiotherapists on managing patients with knee and hip osteoarthritis. Future studies should test the effectiveness of implementing this adapted guideline to improve local physiotherapy care in Hong Kong.
Statistical Insight into China’s Indigenous Diagnosis-Related-Group System Evolution
Authors: Ma Wenlong , Qu Jing , Han Hui , Jiang Zixia , Chen Tiantian , Lu Xuefeng , Lu Jiaoyang
Published: November 2023

The use of Diagnosis-Related Groups (DRG) is a prevalent payment system employed to control hospitalization costs and improve medical efficiency. China has developed an indigenized DRG payment system including Single Disease Payment (SDP), DRGs, and Big Data Diagnosis-Intervention Packet (DIP). In this study, we took cholecystitis as an example, drawing on both primary and secondary data to verify the effectiveness of China’s indigenized DRG system and to introduce the evolution of DRGs in China. Primary data were gathered from Qilu Hospital in 2019–2021. Secondary data were collected from published literature from 2004–2016. Only studies with both pre-SDP/DRG and post-SDP/DRG groups were included. Among the studies included, 92.9% (13/14) reported a significant reduction in hospitalization costs after the implementation of SDP while other studies identified length of stay (LOS) and age as the most significant influential factors in SDP. Furthermore, we elaborated the efficiency of DRGs using data from 2738 inpatients in Qilu hospital. Moreover, 60% (6/10) of the studies from the databases also showed the efficiency of DRGs in different regions. SDP is efficient in saving hospitalization costs, but its implementation is limited. DRGs have a broader scope of application, but their effectiveness remains to be validated. DIP is a brand new concept in China, and more data are needed to assess its efficiency.
Navigating a Pandemic: Leadership Dynamics and Challenges within Infection Prevention and Control Units in Israel
Authors: Chen Dafna , Cojocaru Stefan
Published: November 2023

This study investigates the impact of the coronavirus disease 2019 (COVID-19) pandemic on leadership within infection prevention and control (IPC) units across public hospitals in Israel. Through qualitative interviews with ten IPC managers from nine hospitals, equivalent to 30% of the country’s acute care facilities, the research uncovers significant changes in managerial approaches due to the health crisis. The results reveal four main themes: (1) Enhanced managerial autonomy and leadership skills, with a noted rise in self-efficacy against the pandemic’s backdrop; (2) Shifted perceptions of IPC units by upper management, recognizing their strategic value while identifying the need for a more profound understanding of IPC operations; (3) The increased emphasis on adaptability and rapid decision-making for effective crisis management; (4) The dual effect on job satisfaction and well-being, where greater commitment coincides with risks of burnout. The study underscores the essential nature of effective IPC leadership during emergencies, highlighting the need for clear communication, prompt action, and empathetic leadership. The conclusions point to the necessity for continuous research into IPC leadership, promoting strategic advancements in management to bolster IPC units against future health threats.
Adolescents Concerned about Climate Change: A Hermeneutic Study
Authors: Drumm Kailie , Vandermause Roxanne
Published: November 2023

Climate change is a public health threat on a global scale. Over the last two decades, research has uncovered the myriad health effects of climate change and its associated costs. The literature is also beginning to show the direct and indirect effects of climate change to be an indicator of increased adverse mental health outcomes including excessive worry, anxiety, grief, and post-traumatic stress disorder. The development of scales to measure some of these effects in adult populations has shown the critical need to understand the various ways climate change affects mental well-being in adolescent populations who are at a critical juncture in psychological development. The purposes of this study were to understand the lived experience of adolescents who are concerned about climate change and uncover the meaning of climate change concern for adolescents as informed by emerging patterns. This study utilized Hermeneutic Phenomenology as a philosophical foundation and methodological approach for data retrieval and analysis. An interview-based approach with a purposeful sample (n = 11, aged 12–17 years) revealed the multi-layered elements of climate change concern and its effects. Three patterns emerged: Climate Change as a Temporal Threat and Pressure, Awareness and Concern as a Continuum, and Experiencing Concern and Making Meaning. These findings may now inform interdisciplinary knowledge on upstream mitigation efforts and the promotion of positive outcomes relating to climate change. The need for focused educational attention to adolescent behaviors and concerns is explicated and exemplified.
Audit Expectation Gap in the External Audit of Banks in Mozambique
Authors: Massicame Osvaldo , Inácio Helena Coelho , Bastos Maria Anunciação
Published: November 2023

The function of the external audit, largely as a result of the scandals and financial crises that have occurred, has been the subject of debate and criticism. This aspect has fostered discussions around the Audit Expectation Gap, which, in short, is understood as the differences in expectations between the audit’s results and what is expected from it. In this context, the present study aimed to evaluate the existence of the Audit Expectation Gap in the external audit of banks in Mozambique. For this purpose, auditors, regulators/supervisors, managers and financial staff from banks and companies were surveyed. The results showed statistically significant differences in the opinions of respondents regarding matters related to the scope and objective of the audit, materiality and risk, and different aspects of responsibility. Thus, evidence was obtained that, in addition to reviewing audit regulations for Mozambican credit institutions and financial companies, there is a need for clarification of matters such as the level of security in external audits (which cannot be absolute); the responsibilities of management and auditors in areas such as assessing and reporting compliance with the ratios and prudential limits imposed by the Bank of Mozambique; assessing the suitability of risk management at the bank; and the prevention, detection and reporting of fraud.
Interleukin-33 Expression on Treatment Outcomes and Prognosis in Brazilian Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy
Authors: Albuquerque Renata B. , Borba Maria Amélia S. M. , Fernandes Matheus S. S. , Filgueira Tayrine O. , Martins Danyelly Bruneska G. , Filho José Luiz L. , Castoldi Angela , Souto Fabrício Oliveira
Published: November 2023

Interleukin-33 (IL-33), a member of the interleukin-1(IL-1) family of cytokines, remains poorly understood in the context of human breast cancer and its impact on treatment outcomes. This study aimed to elucidate IL-33 expression patterns within tumor samples from a cohort of Brazilian female breast cancer patients undergoing neoadjuvant chemotherapy while exploring its correlation with clinicopathological markers. In total, 68 samples were meticulously evaluated, with IL-33 expression quantified through a quantitative polymerase chain reaction. The findings revealed a substantial upregulation of IL-33 expression in breast cancer patient samples, specifically within the Triple-negative and Luminal A and B subtypes, when compared to controls (healthy breast tissues). Notably, the Luminal B subtype displayed a marked elevation in IL-33 expression relative to the Luminal A subtype (p < 0.05). Moreover, a progressive surge in IL-33 expression was discerned among Luminal subtype patients with TNM 4 staging criteria, further underscoring its significance (p < 0.005). Furthermore, chemotherapy-naïve patients of Luminal A and B subtypes exhibited heightened IL-33 expression (p < 0.05). Collectively, our findings propose that chemotherapy could potentially mitigate tumor aggressiveness by suppressing IL-33 expression in breast cancer, thus warranting consideration as a prognostic marker for gauging chemotherapy response and predicting disease progression in Luminal subtype patients. This study not only sheds light on the intricate roles of IL-33 in breast cancer but also offers valuable insights for future IL-33-related research endeavors within this context.
The Impact of Cadmium Selenide Zinc Sulfide Quantum Dots on the Proteomic Profile of Saccharomyces cerevisiae
Authors: Le Nhi , Chand Abhishu , Okafor Onyinye , Kim Kyoungtae
Published: November 2023

Quantum dots (QDs) have been highly sought after in the past few decades for their potential to be used in many biomedical applications. However, QDs’ cytotoxicity is still a major concern that limits the incorporation of QDs into cutting-edge technologies. Thus, it is important to study and understand the mechanism by which QDs exert their toxicity. Although many studies have explored the cytotoxicity of quantum dots through the transcriptomic level and reactive species generation, the impact of quantum dots on the expression of cellular protein remains unclear. Using Saccharomyces cerevisiae as a model organism, we studied the effect of cadmium selenide zinc sulfide quantum dots (CdSe/ZnS QDs) on the proteomic profile of budding yeast cells. We found a total of 280 differentially expressed proteins after 6 h of CdSe/ZnS QDs treatment. Among these, 187 proteins were upregulated, and 93 proteins were downregulated. The majority of upregulated proteins were found to be associated with transcription/RNA processing, intracellular trafficking, and ribosome biogenesis. On the other hand, many of the downregulated proteins are associated with cellular metabolic pathways and mitochondrial components. Through this study, the cytotoxicity of CdSe/ZnS QDs on the proteomic level was revealed, providing a more well-rounded knowledge of QDs’ toxicity.
Concepts of Regeneration for Spinal Diseases in 2023
Authors: Yurube Takashi , Han Inbo , Sakai Daisuke
Published: November 2023

It is our pleasure to announce the publication of the Special Issue “Regeneration for Spinal Diseases 3.0” in the International Journal of Molecular Sciences (ISSN 1422-0067) [...]
Face and Predictive Validity of MI-RAT (Montreal Induction of Rat Arthritis Testing), a Surgical Model of Osteoarthritis Pain in Rodents Combined with Calibrated Exercise
Authors: Otis Colombe , Bouet Emilie , Keita-Alassane Sokhna , Frezier Marilyn , Delsart Aliénor , Guillot Martin , Bédard Agathe , Pelletier Jean-Pierre , Martel-Pelletier Johanne , Lussier Bertrand , Beaudry Francis , Troncy Eric
Published: November 2023

Validating animal pain models is crucial to enhancing translational research and response to pharmacological treatment. This study investigated the effects of a calibrated slight exercise protocol alone or combined with multimodal analgesia on sensory sensitivity, neuroproteomics, and joint structural components in the MI-RAT model. Joint instability was induced surgically on day (D) 0 in female rats (N = 48) distributed into sedentary–placebo, exercise–placebo, sedentary–positive analgesic (PA), and exercise–PA groups. Daily analgesic treatment (D3–D56) included pregabalin and carprofen. Quantitative sensory testing was achieved temporally (D–1, D7, D21, D56), while cartilage alteration (modified Mankin’s score (mMs)) and targeted spinal pain neuropeptide were quantified upon sacrifice. Compared with the sedentary–placebo (presenting allodynia from D7), the exercise–placebo group showed an increase in sensitivity threshold (p < 0.04 on D7, D21, and D56). PA treatment was efficient on D56 (p = 0.001) and presented a synergic anti-allodynic effect with exercise from D21 to D56 (p < 0.0001). Histological assessment demonstrated a detrimental influence of exercise (mMs = 33.3%) compared with sedentary counterparts (mMs = 12.0%; p < 0.001), with more mature transformations. Spinal neuropeptide concentration was correlated with sensory sensitization and modulation sites (inflammation and endogenous inhibitory control) of the forced mobility effect. The surgical MI-RAT OA model coupled with calibrated slight exercise demonstrated face and predictive validity, an assurance of higher clinical translatability.
Interleukin Variants Are Associated with the Development and Progression of IgA Nephropathy: A Candidate-Gene Association Study and Meta-Analysis
Authors: Chronopoulou Ioanna , Tziastoudi Maria , Pissas Georgios , Dardiotis Efthimios , Dardioti Maria , Golfinopoulos Spyridon , Filippidis Georgios , Mertens Peter R. , Tsironi Evangelia E. , Liakopoulos Vassilios , Eleftheriadis Theodoros , Stefanidis Ioannis
Published: November 2023

The interleukin-1 gene cluster encodes cytokines, which modulate mesangial cell proliferation and matrix expansion, both constituting central factors in the development and progression of immunoglobulin A nephropathy (IgAN). A candidate-gene study was performed to examine the association of polymorphisms of the interleukin-1 gene cluster with the risk of progressive IgAN. To gain deeper insights into the involvement of interleukin genes in IgAN, a meta-analysis of genetic association studies (GAS) that examine the association between interleukin variants and IgAN was conducted. Association study: The case-control study consisted of 121 unrelated Caucasians with sporadic, histologically diagnosed IgAN and of 246 age- and sex-matched healthy controls. Persistent proteinuria (>2 g/24 h) and/or impaired kidney function (serum creatinine > 1.5 mg/dL) defined progressive (n = 67) vs. non-progressive (n = 54) IgAN cases. Genotypes were assessed for two promoter-region single-nucleotide polymorphisms, C-899T (rs1800587) in IL1A and C-511T (rs16944) in IL1B, and for one penta-allelic variable-length tandem repeat polymorphism (VNTR 86 bp intron 2) in IL1RN. The association of these variants with the susceptibility of IgAN and the development of progressive IgAN (healthy status, IgAN, progressive IgAN) was tested using the generalized odds ratio (ORG) metric. Linkage disequilibrium and haplotype analysis were also performed. Meta-analysis: We included in the meta-analysis 15 studies investigating association between 14 interleukin variants harbored in eight different genes and IgAN. The ORG was used to evaluate the association between interleukin variants and IgAN using random effects models. The present case-control study revealed association of IL1B C-511T (rs16944) with the progression of IgAN (p = 0.041; ORG = 2.11 (1.09–4.07)). On haplotype analysis, significant results were derived for the haplotypes C-C-1 (p = 0.005; OR = 0.456 (0.261~0.797)) and C-T-2 (p = 0.003; OR = 4.208 (1.545–11.50)). Regarding association and meta-analysis results, variants in IL1B (rs1143627 and rs16944), IL1RN (rs928940, rs439154, and rs315951) and IL10 (rs1800871) were associated with IgAN based on either genotype or allele counts. Genetic variants and haplotypes in the IL1B, IL1RN, and IL10 genes might contribute to an increased risk for development and progression of IgAN.