bluuebunny/crossref_metadata_2025 huggingface dataset:
Manajemen Sekolah Ramah Anak Berbasis Komunikasi dalam Al-Qur’an di SMA Negeri 7 Kota Bogor
Authors: Filzah Putri , Fauziah Siti Pupu , Suhermen Irman
Published: December 2024

Penelitian ini bertujuan untuk mengetahui bagaimana manajemen sekolah ramah anak berbasis komunikasi dalam Al-Qur’an di SMA Negeri 7 Kota Bogor melalui tiga garis besar yaitu perencanaan program sekolah ramah anak berbasis komunikasi dalam Al-Qur’an, pelaksanaan program sekolah ramah anak berbasis komunikasi dalam Al-Qur’an dan evaluasi program sekolah ramah anak. Pendekatan penelitian yang digunakan dalam penelitian ini yaitu pendekatan kualitatif dan metode penelitian menggunakan studi kasus. Data penelitian ini adalah data primer yang bersumber dari narasumber dan data sekunder dari dokumen resmi yang dikeluarkan sekolah. Teknik pengambilan data menggunakan wawancara, observasi dan dokumentasi. Keabsahan data menggunakan teknik triangulasi sumber. Hasil penelitian menunjukan bahwa: 1) Perencanaan program sekolah ramah anak berbasis komunikasi dalam Al-Qur’an di SMA Negeri 7 Kota Bogor di latar belakangi dengan adanya pelatihan interaksi guru dengan siswa , Merancang materi pembelajaran yang menggambarkan prinsip-prinsip komunikasi dalam Al-Qur’an, Adanya kebijakan 5S, 2) Pelaksanaan program sekolah ramah anak berbasis komunikasi dalam Al-Qur’an di SMA Negeri 7 Kota Bogor dikelompokan berdasarkan pada prinsip-prinsip sekolah ramah anak yakni nondiskriminasi, kepentingan anak diutamakan, penghormatan terhadap pandangan anak, dan pengelolaan kelas. Prinsip tersebut memberikan dampak positif pada pengalaman belajar siswa dan membantu menciptakan lingkungan belajar yang inklusif, positif dan mengedepankan nilai-nilai kebaikan dan keadilan, 3) Evaluasi program sekolah ramah anak di SMA Negeri 7 Kota Bogor yang menunjukan pentingnya hubungan antara gaya komunikasi siswa, kelancaran berbicara, dan pemahaman materi yang diajarkan. Evaluasi program di SMA Negeri 7 Kota Bogor dilakukan dengan tujuan utama untuk mengidentifikasi kekuatan dan kelemahan program.
Meningkatkan Keterampilan Mendengarkan Pembelajar EFL Indonesia melalui Lagu Bahasa Inggris: Pendekatan ALM
Authors: Amelia Dita , Fatyra Adisa
Published: December 2024

Penelitian ini menyelidiki penggunaan lagu berbahasa Inggris untuk meningkatkan keterampilan mendengarkan pelajar EFL Indonesia dalam kerangka Linguistik dan Media Terapan (ALM). Berdasarkan penelitian sebelumnya yang menyoroti tantangan yang dihadapi pelajar Indonesia karena ketidakbiasaan mereka dengan aksen, pengucapan, dan struktur linguistik asli bahasa Inggris, penelitian ini mengkaji bagaimana lagu berbahasa Inggris dapat berfungsi sebagai sumber tambahan yang efektif dalam pembelajaran bahasa. Metode Audio-Lingual (ALM) diusulkan sebagai pendekatan pedagogi yang sesuai, menekankan penggunaan bahasa kebiasaan dan pembentukan pola bicara melalui pemaparan dan latihan berulang-ulang. Melalui pendekatan observasi dan studi litelatur, data dari berbagai sumber termasuk tinjauan literatur, laporan penelitian, dan pendapat ahli dianalisis untuk mengeksplorasi hubungan antara lagu berbahasa Inggris dan pemahaman mendengarkan. Temuan menunjukkan bahwa lagu berbahasa Inggris menawarkan paparan bahasa otentik, perolehan kosa kata, dan wawasan budaya, sehingga meningkatkan motivasi dan keterlibatan pelajar. Studi ini menyimpulkan dengan menganjurkan integrasi lagu-lagu berbahasa Inggris ke dalam praktik pengajaran bahasa untuk menciptakan lingkungan belajar yang kondusif yang mencerminkan pemerolehan bahasa secara alami, sebagaimana didukung oleh kerangka ALM.
Implementasi Program Wana Wisata Rusa Tanjungsari pada Dinas Kebudayaan dan Pariwisata Kabupaten Bogor
Authors: Pamungkas Tri Bagus , Hermawan Denny , Purnamasari Irma
Published: December 2024

Tujuan dari wana wisata adalah untuk memberikan pengalaman yang menyenangkan kepada pengunjung sekaligus meningkatkan kesadaran akan pentingnya pelestarian alam dan lingkungan. Tujuan utama untuk mengetahui Implementasi Program Wana Wisata Rusa Tanjungsari Pada Dinas Kebudayaan Dan Pariwisata Kabupaten Bogor. Penelitian ini menggunakan metode penelitian deskriptif dengan pendekatan kuantitatif. Dalam penelitian ini populasi yang diambil dari bulan oktober 2023 terdapat 248 orang dan sampel yang didapat ada 72 orang pengunjung wana wisata rusa menggunakan rumus Taro Yamane. Hasil penelitian menunjukan bahwa implementasi program wana wisata rusa tanjungsari secara keseluruhan adalah baik. Hal ini ditunjukkan dengan perolehan nilai rata rata tertinggi yaitu 4.29 dengan kategori ”Baik”. Nilai rata rata terendah yaitu 3.74 dengan kategori ”Baik”
Strategi Perencanaan Pembelajaran untuk Meningkatkan Prestasi Peserta didik
Authors: Hasanah Akviani Fauziah
Published: December 2024

Strategi perencanaan pembelajaran merupakan bagian penting dalam meningkatkan prestasi peserta didik, Strategi perencanaan pembelajaran wajib menyesuaikan dengan kebutuhan peserta didik dan lingkungan pembelajaran, sehingga dapat membantu peserta didik dalam meningkatkan hasil belajar mereka. Riset ini berfungsi  untuk mengeksplorasi strategi perencanaan pembelajaran yang dapat meningkatkan kinerja siswa. Strategi perencanaan pembelajaran adalah  serangkaian rencana kegiatan untuk mengajar bagaimana menggunakan strategi dan sarana pembelajaran. Tujuan utama dari strategi perencanaan pembelajaran adalah untuk mencapai tujuan pembelajaran tertentu.Komponen strategi pembelajaran meliputi isi pembelajaran, metode pembelajaran, media pembelajaran, administrasi, dan keuangan. Oleh karena itu, penelitian ini memberikan pemahaman yang mendalam mengenaibagaimana mengoptimalkan strategi perencanaan pembelajaran  untuk meningkatkan kinerja siswa.
Optimizing the Performance of DC Electric Smart Gate Motor using Ziegler Nichols Tuning Methods
Authors: Kadpan Wpreen Rashed , Mustafa Faiz F. , Kadhim Hussein Tbena , Igor Nikolaevich
Published: December 2024

One of the primary functions of the DC motor is exemplified in its utilization for the automated operation of irrigation gates, which involves a variety of DC motor models. The  DC motor chosen was influenced by the particular operational requirements of the irrigation gate. The ability to support the massive weight of the gate as well as the extreme pressure produced by river water currents are among these requirements. The gate motor utilized functions at a sluggish pace of 20 revolutions per minute. The approach employed involves tuning utilizing the Ziegler-Nichols (ZN) method. The (Proportional-Integral-Derivative) PID controller is designed to precisely manage a DC motor's position, improving the motor's overall performance. The parameters were designed to be Kp = 17, Ti = 1, and Td = 0.1. The Simulation derived from the analysis of MATLAB step response data are side by side with algorithm utilized to certain the dynamic response of the closed-loop configuration. Essential Specifications such as rise time and settling time, both measured in seconds, will be integrated into the simulation outcomes. The utilization of the (ZN) based algorithm for adjusting the gain constants of the PID control system tends to yield superior outcomes in comparison to that under a unity feedback control system .The rising time was 12.6, but when performance improved, it dropped to 0.713. This improvement is also applicable to the settling time, which decreased from 22.4 to 1.13. The holistic evaluation demonstrates that the (ZN) method yields superior performance in contrast to a system employing unity feedback control.
Identification Risks in Road Construction Projects Using Weighted Product Model: Iraq as a Case Study
Authors: Saleh Ahmed M. , Hilal Mustafa A.
Published: December 2024

One of the challenges that developing countries is the necessity to properly manage the risks involved in road construction projects. For that, the present work developed a dissension method to specify effective risk factors in a wide range of approaches and protocols to achieve its objectives. The Influence of Risk Road Implementation on Performance Indicators The initial sets of outcomes were derived from computing the average risk estimate. Subsequently, the second results group was established by assessing the relative importance index (RII) effects. In the RII method and mean results the workers and machinery insurance is the most important. The identical data that had been collected from the weighted product model (WPM) methodology ultimately determined that the essential resources such as staff and equipment must be accessible through all stages of activity. In road construction, machines represent a major effective factor that can help to project success with a rank of 0.868. Also, the worker conditions and skills represent another strategy in projects with 0.547 rank. The weighted product model results yelled a more accurate and practical output.
The specifics and peculiarities of the confessional policy of the Russian Empire in Ossetia in the late XVIII – first half of the XIX centuries
Authors: Kuliyev F. M. , Osipov S. K. , Kasparyan K. V.
Published: December 2024

This article is devoted to the study of the characteristic features of the confessional policy of the Russian administration of the North Caucasus on the territory of Ossetia in the late XVIII and the first half of the XIX centuries. The study analyzes the specifi cs of the spread of the Islamic religion in the Ossetian environment, the complex of external factors that contributed to this process, as well as the nature of interaction between Muslim and Christian Alan communities. In this paper, the features of the policy of the Russian authorities in relation to the Islamic and Orthodox communities of Ossetia are investigated. Moreover, the research disclose the role of the personal factor expressed in the various approaches of the governors of the North Caucasus such as A.P. Ermolov and M.S. Vorontsov to the scientifi c problem under consideration.
Passion and Growth Language Mindset Predict Cognitive and Metacognitive Language Learning Strategy Use: A Study of EFL Learners
Authors: Heshmati Hosain , Heshmati Saida , Karami Hossein
Published: December 2024

This study explored (a) whether language mindset could predict the frequency of Language Learning Strategy (LLS) usage by second language (L2) learners, (b) whether language mindset was a predictor of specific types of strategy use such as direct or indirect language learning strategies, and (c) whether L2 learners’ level of passion in language learning could moderate the relationship between language mindset and LLS use. To address these questions, a total of 102 Iranian English as foreign language learners completed a survey on language mindset, language learning strategy use, and passion for learning a new language. Results indicated a positive significant association between growth mindset and the frequency of cognitive and metacognitive strategy use. When assessing passion as the moderator, no significant moderating effect was observed. However, we found a direct relationship between passion and cognitive and metacognitive LLS use. The findings of this study signify the importance of language mindset as a facilitator of the types of language learning strategies L2 learners adopt to help them more efficiently learn a new language.
Affective well-being trajectories during the transition out of upper secondary education: A measurement burst study
Authors: Sosin Anne , Scott Stacey , Smyth Joshua M. , Neubauer Andreas B.
Published: December 2024

The transition out of upper secondary education represents a critical life event for young adults. Research on trajectories of affective well-being during this period is limited and inconsistent. The present work investigated changes in well-being from shortly before graduating from upper secondary education to approximately one year later. The motivation for a post-school pathway, as well as perceptions of the impact of moving out of home, ending a relationship, and entering a new relationship were examined as potential predictors of between-person differences in well-being trajectories. German-speaking high school graduates (N = 897) reported on their affective well-being in up to four surveys over approximately one year and additionally indicated their motivation for their post-school pathway and life events they had experienced. At three measurement occasions, participants also participated in a three-week experience sampling phase, in which they reported on their daily well-being. Latent change models revealed an initial increase in well-being after graduation, but mixed evidence for subsequent trajectories, as both positive and negative affect decreased on average. Changes in well-being were more pronounced for global assessments of affective well-being. We did not find associations of the motivation for a post-school pathway and the life events with well-being trajectories. Overall, these findings highlight the complexity of well-being trajectories during the transition out of upper secondary education and the importance of using multiple time points and assessment methods to understand these dynamics. Understanding these well-being trajectories is crucial for supporting young adults in their future decisions and improving their overall well-being.
Wilful Construction of Ignorance: A Tale of Two Ontologies
Authors: Lewandowsky Stephan
Published: December 2024

From Iraq’s mythical weapons of mass destruction (WMD) to Donald Trump’s record of more than 10 daily false or misleading statements, deception and false claims have been an integral part of political discourse for quite some time. Nonetheless, Trump’s blatant disregard for the truth has given rise to much concern about the dawn of a “post-truth” era. I argue that there are striking differences between the tacit ontologies of truth underlying the WMD deception and Donald Trump’s false claims, respectively. Whereas the WMD campaign contested a single reality, Trump’s false claims often repudiate the very idea of external truths that exist independently of anyone’s opinion. I consider this ontological shift from realism to extreme constructivism to be the most critical aspect of the current “post-truth” malaise. I note that an extreme constructivist “truth” has formed an essential aspect of historical fascism and Nazism, as well as of contemporary populist movements, and that those conceptions are incompatible with liberal-democratic norms of truth-seeking. I conclude by pointing towards potential solutions of the “post-truth” crisis.
Affective and computational determinants of threat extinction biases
Authors: Stussi Yoann
Published: December 2024

Pavlovian threat acquisition and extinction are fundamental processes by which individuals learn about threat and safety in their environment. Research has shown that humans learn more rapidly and persistently to associate threatening and—somewhat counterintuitively— positive rewarding stimuli with aversive events, beyond their inherent threat value. However, the computational mechanisms underlying these Pavlovian learning biases remain unclear. Here, I examined the affective and computational determinants of Pavlovian threat acquisition and extinction biases for threat-related and positive emotional stimuli. I combined and reanalyzed data from four experiments (N = 247) using a differential Pavlovian threat conditioning paradigm. Computational modeling techniques were applied to identify signatures of these learning biases. Threat-relevant (angry faces, snakes), positive-relevant (baby faces, happy faces, erotic stimuli), and neutral (neutral faces, colored squares) stimuli were used as conditioned stimuli, with skin conductance response serving as an index of learning. Model comparison indicated that a reinforcement-learning model differentiating between excitatory (e.g., learning from reinforcement) and inhibitory (e.g., learning from the absence of reinforcement) learning was the best explanatory model for the observed data. Whereas no evidence for differences in excitatory learning rates was found between stimulus categories, both threat- and positive-relevant stimuli exhibited a lower inhibitory learning rate compared to neutral stimuli, contributing to the persistence of the conditioned response during extinction. These findings provide insights into the mechanisms underlying Pavlovian threat extinction biases, thereby advancing our understanding of how humans attribute and update affective value to their environment.
Balancing Comfort: Deceleration Rate and Environmental Impact at Crosswalks and Intersections in Automated Driving
Authors: Carlowitz Stefanie , Madigan Ruth , Goodridge Courtney Michael , Hilz Jana , Marberger Claus , Alt Philipp , Schulz Michael , Osswalt Sabine , Engeln Arnd , Merat Natasha
Published: December 2024

Understanding passenger comfort in automated vehicles (AVs) is critical for advancing highly automated driving systems. This test track study was conducted in 2023 with N = 41 participants who are accustomed to German driving norms. It examined how deceleration rates and environmental factors influence passenger perceptions in two scenarios: crosswalks and blind intersections. The participants were driven by a real AV, which braked using deceleration rates of -1.5 m/s², -2.5 m/s², and -3.5 m/s². Additionally, at the crosswalk, the pedestrian visibility time, and at the intersection, the presence of an approaching vehicle was varied. The results show that passengers generally prefer lower deceleration rates but accept higher rates (-3.5 m/s²) when the pedestrian becomes visible more unexpectedly. In the intersection scenario, comfort ratings were less influenced by the presence of an approaching vehicle than by the deceleration rate, with lower rates being favoured. These findings are valuable for AV development; however, future research should explore more diverse populations to validate the study’s findings across varying traffic conditions and cultural settings. The study indicates that tailoring AV deceleration to the traffic scenarios can enhance passenger comfort. It can help AV developers define comfortable and safe perceived driving styles without compromising efficiency.
ASSESSMENT OF RED-MOILED COWS OF DIFFERENT GENOTYPES BY DURATION
OF PRODUCTION USE AND LIFETIME PRODUCTIVITY IN BREEDING FARMS OF THE KRASNOYARSK REGION
Authors: Shchegolkov Nikolay , Golubkov Anatoly , Nalvadayev Nikolay , Mirvaliev Firuz , Pashchenko Olga , Efimova Lyubov
Published: December 2024

As a studies result carried out on cows of the Red-Motley
of breeding farms of the Krasnoyarsk Territory with different
degrees of blood in the Holstein breed, it was found that cows
with blood up to 50 % and 50–75 % by Holsteins had in most
herds the highest lifetime productivity, as well as the duration
of production use in most herds. There was a negative relationship
between the degrees of blood and the total number of lactations
in animals, that is, as the proportion of Holstein blood
in cows increased, the period of productive use decreased. Of
the analyzed herds, only a small percentage of animals survived
to the age of four to five lactations, when the maximum
genetic potential for productivity is manifested. Taking these
facts into account, we can talk about greater preference for
using individuals of the above-mentioned genotypic groups
(up to 50 % and 50–75 % by Holsteins) in further selection
and breeding work with Red-Motley cattle. The scientifically substantiated thesis has been confirmed that the early culling of mothers having before 1.6 lactation is a negative indicator, since mothers leave the herd before the time when their daughters do not have time to give birth.
Tweets Classification of Mental Health Disorder in Indonesia Using LDA and Cosine Similarity
Authors: Dwijayanti Irmma , Habibi Muhammad , Kusumaningtyas Kartikadyota , Riyadi Sujono
Published: December 2024

Purpose: Twitter related to mental health has great potential as a medium to provide important information to the public and health organizations on a large scale, but an evaluation of tweet data related to mental health disorders has not been carried out. This study aims to classify tweet data to determine the most common mental health disorders in Indonesia based on the symptoms experienced.Methodology: The classification process is carried out using cosine similarity calculations between tweets data and keywords which are compiled based on theoretical studies and optimization of the LDA topic modeling results.Findings/result:The classification results show that the most discussed issues on Twitter are depression, bipolar, schizophrenia, dementia, and PTSD. Based on these results it can be interpreted that the level of prevalence and public attention to depressive diorders is quite high compared to other disorders. From the results of the classification, it is also possible to identify the most discussed symptoms throughthe emergence of keywords from each category.Originality: Classification is calculated based on the cosine similarity between tweets and keywords compiled from human judgement and enriched using the results of LDA topic modeling to improve classification performance
CRITERIA FOR CHOOSING THE DIAMETERS OF THE ROLLS OF BAR ROLLING MILLS
Authors: Samokhval Volodymyr , Vasyliev Oleksandr , Kontsedal Roman , Loktev Bohdan
Published: December 2024

The purpose of the work is to evaluate the significant of the technological efficiency criterion for choosing the diameter of the rolls and to develop recommendations for the designation of the diameters of the rolls of bar mills. From the analysis of data on roll diameters and rolling technological parameters of existing bar mills, it was established that the main criteria for choosing the roll diameter are bite conditions, strength and wear resistance. It is proposed to supplement this list with a technological efficiency criterion, which is defined as the ratio of elongation and spreading coefficients. The value of the ratio of the diameters of the rolls to the initial rolling thickness is recommended for the preliminary assignment of the diameters of the rolls by groups of stands of bar mills.
Language Death and Revival after Cultural Destruction: Reflections on a Little Discussed Aspect of Genocide
Authors: Jacobs Steven Leonard
Published: December 2024

This contribution is a look at an aspect of cultural genocide which, despite its importance, has generated little to no interest among scholars of genocide. Its overall importance in the destruction of genocidally recipient groups is important to our overall understanding of how groups holding power use a variety of tools at their disposal to destroy other groups having little to no power.
Riscos e benefícios da castração precoce em cães
Authors: Duarte Oksana , Giusti Schran Roberta
Published: December 2024

Early neutering in dogs is a common practice initially aimed at population control and the prevention of behavioral and health issues. The literature suggests that neutering performed before the first year of age may be associated with significant health risks for the animals. Studies show that early neutering can increase the propensity for joint injuries, such as hip dysplasia and cranial cruciate ligament rupture, particularly in larger dogs and certain breeds. Additionally, there is evidence that neutering may elevate the risk of various types of cancer, including hemangiosarcoma, lymphoma, mast cell tumors and osteosarcoma, with the age of neutering and the dog's sex being critical factors in the development of these conditions. In contrast, early spaying of females has shown to be effective in reducing the risk of mammary tumors, especially when performed before the first or second estrous cycle. However, early neutering may also increase the risk of urinary incontinence in females, necessitating appropriate management and treatment strategies. Behaviorally, neutering can lead to improvements in issues such as urine marking, mounting and escaping, particularly in male dogs. This article discusses the importance of carefully evaluating the optimal timing for neutering, considering each dog's specific characteristics and the potential risks and benefits associated with the procedure.
The Epidemiological Trends of Primary Benign and Malignant Bone Tumors in Iran
Authors: Salarvand Samaneh , Abdollahi Alireza , Shams Ardekani Shereen , Mortazavi Seyed Mohammad Javad , Nazar Elham
Published: December 2024

Background & objective: The incidence of various tumors is strongly influenced by racial characteristics, and therefore the distribution of benign and malignant lesions follows different epidemiological and pathophysiological patterns in the societies. This study aimed to evaluate the epidemiological trend of primary benign and malignant bone tumors in the Iranian population.
Methods: In this cross-sectional study, epidemiological and pathological information related to cases of benign and malignant primary bone tumors registered in the data registry of pathology laboratory of Imam Khomeini Complex hospital in Iran between 2017 and 2022 were assessed. Including criteria was all patient with established pathology diagnosis of bone tumors and excluding criteria was patients with incomplete data.
Results: In total, 617 primary bone tumors (233 benign lesions and 384 malignant lesions) were assessed within 5 years between 2017 and 2022. The average age of patients in benign and malignant lesions subgroups was 29.50±16.95 years and 35.30±19.70 years respectively with the highest incidence in the second and third decades of life in both lesion types. Overall, 52.8% of benign tumors and 58.9% of malignant tumors were found in men. The most frequent benign tumors reported in the study periods including osteochondroma found in 30.5%, and enchondroma in 29.2%. Of malignant bone tumors, osteosarcoma was the most prevalent type with an overall prevalence of 32.6% followed by chondrosarcoma (20.8%) and Ewing sarcoma (16.7%). In the case of benign tumors, a decrease in the trend during the last four years was showed, while the trend of malignant tumors was completely upward in the last four years.
Conclusion: The epidemiological distribution of primary benign and malignant bone tumors in Iran is similar to global statistics, but with a downward trend in benign masses and vice versa, an increasing trend in malignant tumors in recent years.
Identification of Tumor Microenvironment Genes in Triple Negative Breast Cancer
Authors: Mistry Mittal , Vora Hemangini
Published: December 2024

Introduction: In triple negative breast cancer (TNBC) an aggressive molecular subtype of breast cancer, tumor microenvironment (TME) is a complex and dynamic ecosystem that plays a pivotal role in the tumor growth, disease metastasis, immune escape and therapeutic resistance. Understanding the TME holds significant potential for identification of biomarkers of TME and pathways associated as therapeutic targets for improving survival in patients with TNBC.
Materials and Methods: The current study evaluated 682 TME related genes by Array Comparative Genomic Hybridization (aCGH) in 55 patients with TNBC.
Results: Gain/amplification of 411 genes and loss/deletion of 196 genes of tumor microenvironment was observed in TNBC. Further PPI network analysis using Cytoscape plugin and degree ranking method identified GNAQ, MAPK1, AKT1, HRAS, and MAPK3 are five key up-regulated hub genes, and IL4, LCK, STAT6, MTOR, and NFKBIA are five key down-regulated hub genes.
Conclusion: Gain/amplification of GNAQ and loss/deletion of LCK leads to activation of PI3K/AKT/mTOR and RAS/MEK pathways which can be targeted to improve survival of patients with TNBC. However, validation of these pathway genes by RT-PCR or protein expression by immunohistochemistry are further needed to establish these biomarkers as therapeutic targets for TNBC.
Histopathological Study of Gastroduodenal Biopsies and to See the Prevalence of Helicobacter Pylori with the Help of Special Stains in Selected Cases in North East India- A Cross Sectional Study in a Tertiary Care Centre
Authors: Sarma Usha , Kalita Upasana
Published: December 2024

Background: Acid peptic disease (APD), including gastric ulcers, duodenal ulcers, and gastro esophageal reflux disease is a common disorder of the gastrointestinal region, the pathogenesis of which involves an imbalance between acid secretion and gastric mucosal defenses. Acid peptic diseases mostly affect the esophagus, stomach, and duodenum. The imbalance could be caused by factors such as H pylori infection and acid secretory abnormalities in APD. Helicobacter pylori infection is a factor in 85% to 100% of duodenal ulcers and 70% to 90% of gastric ulcers. Besides, malignancies are also fairly common in these regions. Due to long standing APD or H. Pylori infection it may lead to dysplastic changes or malignancy in this region. These disorders are easily detected by endoscopy nowadays. This is a cross-sectional study done in 100 cases of gastroduodenal biopsies in a 1 year period.
Aims and Objectives: To see the histopathological spectrum of gastroduodenal lesions and to detect the presence of H. pylori infection in suspected cases with the help of special stains in North East India.
Result: There were 13 cases (%) of Helicobacter pylori gastritis diagnosed by H&E and Giemsa staining procedure. Out of the 13 cases, the highest number of cases, 46.1% was in the age group of 51-60 years. Out of the 13 cases of H. Pylori gastritis, 11 cases (84.6%) were male and 2 cases (15.3%) were female. The male: female ratio is 5.5 : 1.
The Relationship between Tumor Budding and Stromal Maturity with Tumor Characteristic and Survival in Patients Gastric Cancer
Authors: Kamrani Ghodsieh , Noshadi Nasibeh , Hosseini Akramasadat , Nikbakhsh Novin , Ranaee Mohammad , Alizadeh-Navaei Reza
Published: December 2024

Background: Considering the prognostic role of stromal maturity and tumor budding in various cancer types, along with the importance of gastric cancer as the fifth most prevalent cancer globally and the second leading cause of cancer-related mortality, this study aimed to investigate the impact of stromal maturity and tumor budding on patients with gastric cancer.
Methods: In this retrospective cohort study, 91 patients diagnosed with gastric cancer and who underwent total gastrectomy in educational hospitals of Babol between 2016 and 2021 were evaluated. Slides corresponding to the deepest invasive tumor edge were reviewed by two independent pathologists to assess tumor budding and stromal maturity. Immunohistochemical staining with AE1/AE3 marker was used to correlate the results of tumor budding evaluation. Other pathological information was collected from patients’ records, and patient survival data were obtained through telephone follow-up. Data analysis was performed with SPSS V.22, utilizing T-test, Anova, Chi-square, Fisher’s exact test, Kaplan-Meier and Cox regression method. P-value <0.05 was considered as significant level.
Results: The average survival of patients without tumor budding was 64.64 months, while the average survival of the low tumor budding group (less than 5 tumor buds in 10 microscopic fields at ×400 magnification) was 58.38 months, and the high tumor budding group (less than 5 tumor buds) had an average survival of 28.52 months (p=0.002). The average survival of patients with and without stromal maturity was 41.43 and 61.36 months, respectively (p=0.501).
Conclusion: Tumor budding is an independent prognostic factor in gastric adenocarcinoma, but its predictive value is limited to the intestinal type of adenocarcinoma
Biosynthesis and Characterization of Silver Nanoparticles Using Cleistanthus collinus; Investigation on Molecular Mechanism of Apoptosis Cell Death Against Lung Cancer Cells
Authors: Kanipandian Nagarajan , Ramesh Ramar
Published: December 2024

Background: The discovery of novel molecular and cellular signaling pathways for cancer medicines would enhance the efficacy of cancer therapy. In the current study, we made an effort to explore the mitochondrial-mediated apoptosis cell death signaling pathway in A549 lung cancer cells by silver nanoparticles (AgNPs) synthesized from leaf extract of Cleistanthus collinus.
Methods: In-depth, A549 lung cancer cells were treated with AgNPs, and further studies such as HOECHST 33342, AO/EB, Rhodamine-123 staining, flowcytometry, RT-PCR, and Western blotting techniques (24, 48, and 72 h) evidenced apoptosis pathway in cancer cells.
Results: Indeed, the microscopic studies proved that AgNPs-treated lung cancer cells appeared with cell shrinkage, membrane swelling, and apoptotic body formation whereas the untreated cells (control) failed to show any morphological consequences. The flow cytometry analysis revealed the G2/M phase of cell cycle arrest by cells were accumulated in large numbers. The RT-PCR data confirmed the expression (Bax and p53) and suppression (Bcl 2) apoptosis-responsive genes in cancer cells. Finally, immunoblotting proved the increased expression of cytochrome c, initiator caspase 9, and executioner caspase 3, which are effective proteins of intrinsic apoptosis activation.
Conclusion: Ultimately, the overall present investigations confirmed the mitochondrial signaling pathway played a key role in inducing apoptosis in A549 cancer cell death and demonstrated that AgNPs are novel therapeutic agents for cancer nanomedicine
Utilizing Niosome Nanoparticles for the Combined Treatment of Curcumin and Cisplatin in Oral Cancer
Authors: Rezaei Fatemeh , Fesharakinia Tara , Balsini Gavanaroudi Soheil , Rezaeianjam Maryam , Khanlari Goodarzi Mahyar , Abdollahi Maasoume , Akaberi Kiomars
Published: December 2024

Overview: Oral cancer remains a significant health challenge due to its aggressive nature and limited treatment options. This study investigates the use of niosome nanoparticles to deliver a combination of curcumin and cisplatin, a natural anti-inflammatory and anti-cancer agent and a widely used chemotherapeutic drug, respectively.
Methods: Niosome nanoparticles were formulated and optimized for encapsulation efficiency and stability. The physicochemical properties of the nanoparticles were characterized, including particle size, zeta potential, and polydispersity index (PDI). In vitro cytotoxicity assays were conducted using oral cancer cell lines to evaluate the efficacy of the combined treatment.
Results: The niosome formulations with a mean particle size of approximately 150 nm, a favorable zeta potential of 24.6 ± 3.2 mV, and a low PDI of 0.23 ± 0.05. The release profile showed a controlled and sustained release of both curcumin and cisplatin over 48 hours, with a cumulative release of 51% for curcumin and 48% for cisplatin. In vitro studies revealed that the combined treatment significantly reduced cell viability compared to individual treatments, with a synergistic effect observed at specific concentrations.
Conclusion: The findings suggest that niosome nanoparticles can effectively deliver a combination of curcumin and cisplatin, enhancing the therapeutic potential against oral cancer. This innovative approach may pave the way for more effective treatment strategies, ultimately improving patient outcomes in oral cancer therapy
Prospective Observational Study on Esophagitis in Breast Cancer Patients with Supraclavicular Nodal Irradiation - A Common Predicament
Authors: Patro Gyanendra Kumar , Sharma Neeti , Kumar H S , Jakhar Shankar Lal , Meena Ravi , Agnivashya Rajshekhar
Published: December 2024

Background: The present study aimed to assess the dosimetric parameters that may be associated with oesophagitis in patients with breast cancer undergoing three-dimensional radiotherapy.
Methods: A single-arm study was conducted on 25 breast cancer patients. Enrolled patients received 40.05Gy in 15 fractions to the chest wall and supraclavicular nodes with 3DCRT. Toxicity grading was examined once a week to assess the onset of grade 2 esophagitis in respective patients. Analyzed parameters incorporate mean oesophageal dose and maximum doses to the esophagus, esophagus volume, and oesophageal length within the supraclavicular nodal PTV treatment area.
Results: The mean age was 43.48 years and Grade 2 oesophagitis was noted in 13 of the 25 patients (52%). The onset of oesophagitis was significantly associated with the oesophageal length associated with the treating area (p= 0.04). The laterality of disease did not show a significant relation (p=0.93). For the commencement of grade 2 oesophagitis, odds ratios were 2.33 (95% CI=1.1-3.89, p=0.02) for a mean esophageal dose ≥12Gy and 2.5 (95% CI=1.2-5.18, p=0.04) for ≥ 4.5 cm of esophagus length within supraclavicular nodal PTV area.
Conclusion: In patients receiving radiation to the supraclavicular area, the mean oesophageal radiation dose and oesophageal length included in the treatment area correlate with the development of acute oesophagitis, which can be minimized by reducing those two parameters.
Dissecting the Tumor Microenvironment (TME) to Decipher New Immunotherapy Targets by Using Artificial Intelligence
Authors: Rehmani Mohd Umar , Aggarwal Soham , Prasad Chandra Prakash , Singh Mayank
Published: December 2024

Cancer remains one of the leading causes of death worldwide, second only to cardiovascular diseases. Standard cancer treatments, such as chemotherapy, radiation, and surgery, are effective for primary tumors but often fail to eliminate disseminated tumor cells responsible for metastasis. This limitation underscores the necessity for advanced therapeutic strategies, leading to the rise of immunotherapy, which leverages the immune system to combat cancer. Despite its promise, immunotherapy faces challenges, including variable patient responses and immune-related toxicities, complicating the prediction of treatment efficacy. Here, artificial intelligence (AI) emerges as a vital tool that can enhance the precision and effectiveness of immunotherapy by analyzing the intricate tumor microenvironment (TME). This paper explores the limitations of current immunotherapies and examines how AI can address these challenges. It discusses the TME’s role in shaping immune responses, highlighting how understanding its complexities can improve predictive power and treatment outcomes. Furthermore, we address the limitations of AI in cancer research and propose future directions for its integration into clinical practice, with the potential to revolutionize personalized cancer therapy and improve overall patient care.
دور توظيف بيئة إلكترونية في تعزيز الممارسات الإسلامية لدى مرحلة الطفولة المبكرة من وجهة نظر المربيات
Authors: البعلوجي أدهم حسن , الفرا رندة نصر الله
Published: December 2024

الأهداف: هدف البحث للكشف عن دور توظيف بيئة إلكترونية في تعزيز الممارسات الإسلامية لدى مرحلة الطفولة المبكرة من وجهة نظر المربيات بمحافظة خان يونس. المنهجية: اتبعت الدراسة المنهج الوصفي التحليلي تم تطبيق أداة البحث (الاستبانة) على عينة عشوائية من مجتمع البحث، بلغت (84) مربية. النتائج: كشفت النتائج عن أن تقديرات أفراد العينة حول دور البيئة الإلكترونية في اكتساب الممارسات الإسلامية لدى مرحلة الطفولة المبكرة جاءت بدرجة مرتفعة جدًا، وجود فروق ذات دلالة إحصائية بين متوسطات استجابات أفراد عينة الدراسة حول دور البيئة الإلكترونية في اكتساب الممارسات الإسلامية لدى مرحلة الطفول المبكرة تبعًا لمتغير المؤهل العلمي، وغيرها من النتائج. الخلاصة: بناءً على ما أسفرت عنه نتائج البحث، فإن الباحثين يوصيان بما يلي: عقد ورش عمل تهدف إلى بيان أهمية التنويع في الأنشطة الإلكترونية المساعدة لتعزيز الممارسات الإسلامية لدى أطفال رياض الأطفال، عقد دورات تدريبية لمربيات رياض الأطفال لتدريبهم على البيئات الإلكترونية.
Pengaruh Humas KPU Kota Banjarmasin Terhadap Peningkatan Pemilih Pemula (Studi Pada Pelajar SMAN 3 Banjarmasin)
Authors: Khair Rifky Akbar
Published: December 2024

Penelitian ini bermaksud mencari seberapa besar pengaruh strategi humas KPU kota Banjarmasin terhadap peningkatan pemilih pemula (Studi pada pelajar SMAN 3 Banjarmasin). seberapa jauh pengaruh Humas KPU terhadap peningkatan pemilih pemula pada pelajar SMAN3 Banjarmasin khususnya bagi yang sudah bisa memilih pada pemilu maupun pilkada. Penelitian ini menggunakan jenis penelitian kuantitatif deskriptif dengan menyebarkan kuesioner kepada 89 pelajar SMAN 3 Banjarmasin untuk mengumpulkan data-data. Proses analisis data terdiri dari uji validitas, uji rehabilitas, uji normalitas, uji linearitas, regresi linier sederhana, koefisien korelasi (R), analisis koefisien determinasi, dan uji hipotesis. Hasil dari penelitian ini dapat disimpulkan bahwa berdasarkan hasil perhitungan Uji Koefisien korelasi diperoleh nilai korelasi sebesar 0,600 masuk pada interval 0,60 – 0,79, sehingga dapat disimpulkan bahwa tingkat kekuatan hubungan antara strategi humas terhadap peningkatan pemilih pemula memiliki tingkat hubungan yang kuat. Selain itu Uji hipotesis digunakan untuk mennetukan validitas dari system regresi linier. Hasil penelitian menunjukkan humas KPU Kota Banjarmasin memberikan pengaruh terhadap peningkatan pemilih pemula pada  pelajar SMAN 3 Banjarmasin.
The Philosophical Roots of Hadewijch’s Conception of the Human Rede
Authors: Savynska Inna
Published: December 2024

Studies of the heritage of Hadewijch from Brabant mostly focus on the theological sources of her Love mystic (Minnemystik), disregarding the philosophical genesis of her ideas. In this article, I provide arguments in favour of the hypothesis of the philosophical roots of several Hadewijch’s concepts. It is about the parallels among the conception of (1) Rede (Reason) as an image of the Trinity in the human soul and Augustine’s Neoplatonic tradition; (2) life under the guidance of the Reason as the way of recognition and self-control and Seneca’s stoicism; (3) Rede in the image of the queen as the factor of growing of the epistemic virtues which prepare the human soul to the unity with God (Minne) and images of the Lady Dialectic by Martianus Capella, and Lady Philosophy by Boethius.
The Problem of the Dual Character of Logic (a Historical-Logical Survey)
Authors: Khomenko Iryna , Shramko Yaroslav
Published: December 2024

This paper argued that interpreting logic solely as a formal discipline is unjustified, as this science has always included a significant informal component related to its application in argumentative discourse. The Aristotelian paradigm, based on the subject-predicate approach to the logical-philosophical analysis of language, has influenced the history of logic significantly. The functional analysis of language introduced by Gottlob Frege marked a shift to the modern logical paradigm. This led to the rise of symbolic logic, disrupting the established balance between the formal and informal components of logical knowledge for a time. The application of the latest analytical methods in informal logic has enabled research in this field to meet contemporary scientific standards. This development helps restore the balance between the formal and informal aspects of general logic.
Untranslatability as Historical Chronotope. Cassin, B., & Sigov, C. (Eds.). (2024). European dictionary of philosophies: Ukrainian context. Lexicon of untranslatables. Chapter VII (Vol. 5, pp. 215-248). Kyiv: Duh i Litera.
Authors: Chukhrai Elvira
Published: December 2024

Review of Chapter VII “Language, Culture, Historyˮ from Volume V of the European Dictionary of Philosophy (Kyiv: Duh i Litera, 2024).
The safety, accuracy, and feasibility of robotic assistance in neuro-oncological surgery
Authors: Gurses Muhammet Enes , Khalafallah Adham M. , Gecici Neslihan Nisa , Gökalp Elif , Shah Khushi Hemendra , DeLong Chase Alan , Susic Nikola , Brochu Baylee , Lu Victor M. , Shah Ashish H. , Ivan Michael E. , Komotar Ricardo J.
Published: December 2024

OBJECTIVE

Over the past 3 decades, robotic technology has advanced significantly across surgical fields, driven by improvements in versatility, stability, skill, and tactile properties. Neurosurgery has led the way in integrating robotics to improve the accuracy and safety of procedures that require high precision. This study aimed to present one of the largest series in the literature and investigate the feasibility and effectiveness of robotic assistance in neuro-oncological surgery.

METHODS

The authors performed a retrospective review of the medical records of patients who underwent stereotactic biopsy only and biopsy and laser interstitial thermal therapy (LITT) using the Robotic Surgical Assistant (ROSA) system. The ROSA system was used for trajectory planning as well as the precise alignment and insertion of the needle and/or laser catheter. All procedures were performed by a single neurosurgeon. Electronic medical records were reviewed for patient demographics, preoperative clinical deficits, diagnosis, preoperative and postoperative MR images, lesion characteristics including location and volume, postoperative complications, and deficits.

RESULTS

A total of 348 patients were identified. The mean age at surgery was 61.4 years, with 171 (49.1%) females. The most common presentations were GBM (40.5%, n = 141), metastasis (16.4%, n = 57), and radiation necrosis (9.8%, n = 34). A total of 189 (54%) patients underwent stereotactic biopsy only, and 159 (46%) underwent biopsy and LITT. The diagnostic yield of the cases was 98.6%, with only 5 cases having inconclusive pathology. Two (0.6%) patients experienced postoperative complications that resolved during follow-up. Ten (2.9%) patients developed asymptomatic subcentimeter hematomas following the procedure that did not require further intervention. No long-term consequences or permanent deficits occurred in any case within a median follow-up duration of 4.4 months (IQR 1–11.2 months).

CONCLUSIONS

These results indicate that a robot-assisted approach for stereotactic biopsies and LITT is associated with a comparable diagnostic yield and safety profile for frameless and frame-based techniques. Its precision, user-friendly interface, and adaptability contribute to its suitability for such procedures. Future research, especially in long-term results and cost-effectiveness, will be crucial in fully understanding the utility and potential of this technology for broader applications in the field.
Comparison between robot-assisted and navigation-guided minimally invasive transforaminal lumbar interbody fusion: a multicenter study
Authors: Heath Dennis Chen , Chang Hsuan-Kan , Chang Chih-Chang , Yang Hao-Chien , Tu Tsung-Hsi , Hsu Bing-Hung , Lin Ming-Chin , Wu Jau-Ching , Lin Chien-Min , Huang Wen-Cheng , Liu Heng-Wei
Published: December 2024

OBJECTIVE

Both robot and computer navigation have significantly improved the accuracy and safety of percutaneous pedicle screw placement compared with a freehand fluoroscopy-guided technique. However, how the two new technologies compare with each other is unknown. The aim of this study was to investigate the accuracy and safety of robot-assisted and navigation-guided percutaneous pedicle screw placement in minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF).

METHODS

A multicenter, retrospective study was conducted with patients who underwent 1- to 3-level MIS-TLIF from 2019 to 2022. The surgical indication was symptomatic spinal stenosis and spondylolisthesis that failed conservative management. Screw accuracy and safety were compared between robot and computer navigation systems by obtaining postoperative CT images in all patients. The screw accuracy was determined by the Gertzbein and Robbins classification.

RESULTS

A total of 100 patients were divided into robot-assisted (RA; n = 42) and O-arm navigation (ON; n = 58) groups, with 514 percutaneous pedicle screws placed. Clinically satisfactory accuracy was achieved in 100% of the RA group and 92.1% of the ON group (p < 0.001). There were no medial breaches or revision surgeries for screw malposition in either group. The RA group showed similar overall operation time to the ON group (263.54 ± 114.33 vs 243.4 ± 68.96 minutes, p = 0.2821). Subgroup analyses showed that there was no difference in 1-level MIS-TLIF, but the RA group had significantly more operative time for 2-level MIS-TLIF than the ON group (324.67 ± 101.25 vs 266.4 ± 66.38 minutes, p = 0.0264).

CONCLUSIONS

Screw accuracy was significantly better in the RA group, with slightly more operation time, compared with the navigation group. Neither group required revision surgery or reoperation for screw malposition.