bluuebunny/crossref_metadata_2025 huggingface dataset:
RELATIONSHIP BETWEEN ENVIRONMENTAL SANITATION AND THE INCIDENCE OF DIARRHEA IN TODDLERS IN THE WORK AREA OF THE CIRENDEU HEALTH CENTER, SOUTH TANGERANG CITY IN 2022
Authors: Nurul Anggraini  , Dewi Purnamawati
Published: March 2024

According to the World Health Organization (WHO) each year diarrhea causes 525,000 deaths in toddlers and results in 1.7 million children in the world suffering from diarrheal diseases. Riskesdas results in 2018 showed the prevalence of diarrhea in all ages as much as 8%, in toddlers as much as 12.3%, and in infants as much as 10.6%. Sample Registration System The coverage of diarrhea services in 2021 at all ages was 33.6% while in toddlers it was 23.8%. This research is a type of quantitative research with a cross-sectional study design that uses purposive sampling techniques. This research was conducted on mothers who have toddlers in the Cirendeu Health Center Working Area in 2022. The sample in this study was 77 respondents. The data analysis technique in this study was univariate and bivariate using the Chi-square test. Bivariate test results using the Chi-Square test with α = 0.005  found results There is a relationship between environmental sanitation and the incidence of diarrhea in toddlers in the Cireundeu Health Center Working Area in 2022 with (p-value =  0.003 ≤ α = 0.05) and a Odds ratio value of 6.042. Based on the results of the study, this study states that there is a relationship between environmental sanitation and the incidence of diarrhea in toddlers in the Cireundeu Health Center Working Area in 2022. Provide education on the importance of trash cans that are closed and tightly closed.
ANALYZING THE INTERSECTION OF SMOKING CONSEQUENCES IN ISLAMIC JURISPRUDENCE AND ITS DIVERSE PERSPECTIVES
Authors: Muhammad Labib  , Syahrullah  , Raghib Filhaq  , Fakhrurazi Reno Sutan  , Saiful Bahri
Published: March 2024

The leading preventable cause of fatality in contemporary society is smoking.  In Islamic law, smoking is inextricably linked to the examination of the Qur'an, Hadith, and Ijtihad. This literature review examines the intricate convergence of smoking repercussions and Islamic jurisprudence, delving into the varied viewpoints concerning this matter within the Islamic tradition. This research examines fundamental Islamic scriptures, such as the Al-Quran, Hadith, and Ijtihad, in order to reveal the diverse array of principles and perspectives that influence Islamic perspectives on smoking. A spectrum of perspectives exists within Islamic jurisprudence regarding smoking, ranging from permissibility to prohibition, according to a synthesis of the relevant literature. The research emphasizes the complex correlation between smoking and Islamic ethics, taking into account elements such as personal accountability and health repercussions. Furthermore, the analysis discerns significant themes and recurring arguments that influence the varied viewpoints on smoking in Islamic thought as presented in the literature. In summary, this literature review highlights the intricacy of the matter through its provision of an all-encompassing examination of the varied viewpoints concerning the repercussions of smoking within the realm of Islamic jurisprudence. The results of this research enhance our comprehension of the ethical implications and difficulties linked to smoking in an Islamic framework. As a result, policymakers, practitioners, and scholars in the disciplines of health and religious studies will gain invaluable knowledge from these results.
HARMONY AND HEALTH: APPROACH TO IDENTIFYING RISK FACTORS AND COMPLICATIONS OF DIABETES MELLITUS
Authors: Dina Rahma Fadlilah  , Irna Hasanah  , Sadya Bustomi  , Abul A'la Al Maududi
Published: March 2024

Diabetes mellitus, commonly referred to as diabetes, is a chronic condition characterized by lifelong affliction. This study employs the literature review methodology, wherein researchers undertake a systematic examination of a range of current publications encompassing diverse genres. The objective of this study is to explore diverse concepts and theories that can subsequently be formed to align with the research objectives. Diabetes mellitus (DM) is a chronic metabolic condition with several causes, characterized by elevated blood glucose levels and associated metabolic dysregulation of carbohydrates, lipids, and proteins due to insufficient insulin activity. Diabetic foot is recognized as a notable consequence of diabetes mellitus. The management of diabetic foot can be improved with the implementation of foot workouts. Typically, individuals diagnosed with diabetes mellitus have access to several treatment options, including insulin therapy, administration of diabetic medications, exploration of alternative treatments, consideration of surgical interventions, and adoption of a healthier lifestyle.
The new cooperativism, the commons, and the post-capitalist imaginary
Authors: Vieta Marcelo , Lionais Doug
Published: March 2024

This article explores the intersection of the commons and co-operatives resonating with the concept and practices of today’s new cooperativism. We argue that the commons, understood as a transformative vision for the social stewardship of vital dimensions of social and economic life, is a key animator of the co-operative difference and that the new cooperativism re-establishes co-operatives within their radical commons heritage. We begin the article with a brief review of the history of co-operatives and their relationship to capitalism and crises. We then explore the issue of the commons as a unifying force of post-capitalistic thought and practice and connect it to the new cooperativism. To illustrate the possibilities inherent to the co-operative form for a more radical, post-capitalist vision, we then turn our attention to an illustrative case of new cooperativism today — Argentina’s worker-recuperated enterprises. This case demonstrates the potential vibrancy of commons-based co-operatives for a post-capitalist alternative, offering tantalising details of the new cooperativism in practice. The final section provides a discussion of new cooperativism’s possibilities for organising the commons and catalysing post-capitalist imaginaries.
The problem of social care: A co-operative solution
Authors: Bird Alex , Birchall Andrew , Mangan Anita , McKeown Mick , Ross Cilla , Taylor Simon
Published: March 2024

This short paper responds to Johnston Birchall’s observations on the future of the co-operative movement in relation to the crisis of social care in the UK. The authors put the case for a union co-operative model that offers a means for forming worker co-operatives for social care inclusive of trade unions and framed around an ethic of care, enhanced worker voice, and wider democratic participation in the sector.
Johnston Birchall - A bibilography
Authors: Myers Jan
Published: March 2024

As part of the commemoration of the work and contribution made to co-operative studies by Johnston Birchall, this bibliography includes articles, book chapters, edited books and monographs, reports, some conference presentations, and news articles.
New cooperativism seminar series – Review
Authors: Ridley-Duff Rory
Published: March 2024

In 2021, the UK Society for Co-operative Studies (UKSCS) formed an editorial board with the European Research Institute for Cooperative and Social Enterprise (EURICSE), the EMES International Research Network (EMES), and Sheffield Hallam University (SHU) to organise a seminar series on “new cooperativism”. Each seminar followed a strict research protocol to elicit narratives from experts in the field. An experienced facilitator introduced and interviewed panellists before dividing seminar participants into breakout groups. Members of each breakout group reported on their discussions and debates before panellists gave closing statements. In this article, I review videos and transcripts of the seminars. These not only reveal how new cooperativism was framed by the editorial board during the seminar series, but also presents findings that suggest a new consensus amongst practitioners and researchers. By rejecting neoliberal doctrine, grassroots movements are fostering a culture of mutuality that supports co-operative development and accounting practices aligned to sustainable development.
A few drops of plurality: New cooperativism beyond categorisation
Authors: Svensson Christian F
Published: March 2024

Co-operativism comprises a diversity of stakeholders and motivations that often overlap and that are sometimes contradictory. These pluralist practices are difficult to place within typologies and registration models, which invites a discussion of the nature of ‘new cooperativism’, and a potential expansion of frameworks. It is prudent to discuss how we may achieve more nuanced understandings of new cooperativism to shed light on its ambiguities and possibilities. The question is, then, how alternative and pluralist practices in the ever-changing landscape of civil society and co-operativism can — or should — be framed or defined.
Johnston Birchall - A giant of co-operative scholarship
Authors: Matthews Nick
Published: March 2024

An appreciation of Johnston Birchall. Nick Matthews is a director of the Heart of England Co-operative Society, and Senate member at the Co-op Group. He has recently retired (2020) from his term of office as Chair of Co‑operatives UK. He is, amongst other things, reviews editor for the Journal of Co-operative Studies and a ‘serial co-operator’.
Portfolio Optimization of Technology Companies in Malaysia: An Application of Fuzzy TOPSIS-Mean-Absolute Deviation Approach
Authors: Siew Lam Weng , Jaaman Saiful Hafizah , Hoe Lam Weng
Published: March 2024

Selecting and weighting the companies are the main processes in portfolio optimization. It is important to select and determine the companies' weights in constructing the optimal portfolio. In this paper, we propose a two-phase Mean-Absolute Deviation (MAD) model in portfolio optimization of technology companies in Malaysia. In the first phase, the companies’ financial performance is determined and ranked with Fuzzy Technique for Order of Preference by Similarity to the Ideal Solution (TOPSIS). Selection of the good financial performance companies can minimize the influence of firm-specific risk in minimizing the risk of the portfolio at the expected return. In the second phase, the optimal portfolio is generated by weighting the selected companies with MAD model. The results indicate that the investors can minimize the portfolio risk to achieve the expected return with the two-phase MAD model. The significance of this paper is to contribute to the development of portfolio optimization by integrating the Fuzzy TOPSIS and MAD approaches.
Examining the Issues of English-Speaking Skills that University EFL Learners Face
Authors: Thi Tuyet Hanh Nguyen
Published: March 2024

Speaking English is a regular part of the academic routine for EFL students enrolled in Vietnam's top undergraduate English programs. Occasionally, this approach poses numerous issues for first-year undergraduate students at both public and private universities. Despite its significance, not enough information was discovered regarding the difficulties Vietnamese university students have speaking English. One hundred and one students and twelve teachers from six universities participated in the current study, which used mixed methods to investigate the speaking issues encountered by undergraduate students. The outcome demonstrates that English majors at public and private universities encounter numerous difficulties when trying to communicate in the language. But according to this survey, students at public universities have somewhat better English proficiency and experience fewer issues than those at private universities. The participants shared their varied perspectives on how curricula, methods of instruction, and specific institutions might help students overcome their limited proficiency in speaking English. Lastly, the study offers the relevant stakeholders a number of highly detailed recommendations based on the findings.
Psychological Assessment and Behavior of Students: An Intervention for School Curriculum and Development Plan
Authors: Lito D Mallillin Leovigildo , Cumer B Mallillin Marianne
Published: March 2024

The study aims to identify the extent of psychological assessment and behavior of students as a basis for an intervention of a school curriculum development plan program among the respondents. Mixed methods are utilized in the study which is a triangulation of Focus Group Discussion (FGD). On the other hand, convenience sampling is used in the selection of the sample size in the study. The study consisted of Two Hundred Fifty (250) psychology students from the different Higher Education Institutions in Metro Manila. It shows that extent of psychological assessment on the behavior of students manages and transforms difficulties that affect the persons’ success and performance and the person’s ability to face obstacles, problems, and situations in life opportunity and advantage, it shows that intelligent quotient determines the ability of the person to utilize his ability on logic, essentials in getting right, and make wise prediction, it shows that emotional quotient determines the assessment based on individual responses to a situation, it shows that spiritual quotient develops self-awareness in discovering and connecting true self-image aligns with the purpose of individual souls, it shows that creative quotient is designed to measure the baseline of creativity aptitude and capability of individual person, and it shows that adversity quotient determines how people can adapt and walk to overcome situation and hardships. Findings show that there is a significant agreement on the extent of psychological assessment and behavior of students as an intervention for school curriculum development plan program as observed among the respondents.
Analisis Unsur Intrinsik Dalam Film Nussa: The Movie Sutradara Boni Wirasmono Dalam Merepresentasikan Nilai Moral Pada Anak- Anak
Authors: Ryan Fadhil Firmansyah  , Dani Manesah
Published: March 2024

This research is entitled Analysis of Intrinsic Elements in the Film Nussa: The Movie Director Boni Wirasmono in Representing Moral Values to Children. The animated film Nussa: The Movie is an animated film with a family, comedy genre and is popular with children because this type of film is packaged in a funny and interesting way. The animated film Nussa: The Movie was produced by The Little Giantz studio and Visinema Pictures and directed by Bony Wirasmono. The aim of this research is to emphasize the intrinsic elements in the form of characters, plot and setting contained in the animated film Nussa: The Movie directed by Boni Wirasmono. In this research, researchers used qualitative descriptive methods to find the intrinsic elements contained in the animated film Nussa: The Movie.
Controlled operation modes in a HTS composite-based current switch
Authors:   National research nuclear university «MEPHI», Martirosian I. V. , Mikhailova I. K. ,   National research nuclear university «MEPHI», Pokrovskii S. V. ,   National research nuclear university «MEPHI», Rudnev I.A. ,   National research nuclear university «MEPHI»
Published: March 2024

В настоящей работе представлены результаты экспериментальных исследований процессов переключения высокотемпературных сверхпроводящих лент под действием импульсной токовой нагрузки микросекундной длительности. Реализованы обратимое, устойчивое и необратимое переключения сверхпроводника в нормальное состояние. Для демонстрации возможности осуществления контролируемой генерации переходных процессов в сверхпроводящих композитах на основе экспериментальных результатов проведен расчет характеристик сверхпроводящего коммутатора, способного выполнять переключение между различными типами терминальных возбуждений, в частности возможности одновременной отсечки питания по току и напряжению.
VIVÊNCIAS NA CIBERCULTURA POR ADOLESCENTES: PESQUISA COM ESTUDANTES DA REDE MUNICIPAL DE ENSINO DE JUIZ DE FORA
Authors: Júnior Sebastião Gomes de Almeida
Published: March 2024

O presente artigo, fruto de uma pesquisa de doutorado em educação, fundamentada nos estudos de cibercultura e na perspectiva histórico-cultural, parte da questão: Como os adolescentes constituem suas vivências nas tecnologias digitais? Busca-se compreender de que modo esses sujeitos potencializam seu desenvolvimento na apropriação de instrumentos e signos culturais, em meio às redes sociotécnicas da atualidade. Para aproximação de campo, foi elaborado um survey para conhecer práticas e opiniões de estudantes de 8º e 9º anos do Ensino Fundamental da rede municipal de ensino da cidade de Juiz de Fora, Minas Gerais, realizado com 930 adolescentes com idades entre 12 e 17 anos, de 32 estabelecimentos escolares. No desenvolvimento teórico-metodológico, com base no conceito de vivência (perejivanie) de L. S. Vigotski, são explorados mapas vivenciais com 12 adolescentes de quatro escolas que haviam aderido ao questionário on-line. Mediante entrevistas dialógicas, na perspectiva da escuta dos sujeitos, os participantes apresentam suas vivências na cultura digital, envolvendo seus espaços-tempos cotidianos.
E drejta penale Shqiptare në periudhën 1939-1945
Authors: Cuka Marbona
Published: March 2024

Objekt trajtese e këtij punimi është zhvillimi i legjislacionit penal shqiptar në periudhën 1939-1945. Arsyeja e përzgjedhjes së kësaj periudhe është se, ende Shqipëria e fillimit të mijëvjeçarit të ri vazhdon të ndikohet nga ngjarjet dhe çështjet e kësaj periudhe që përkon me Luftën e Dytë Botërore. “Për të kuptuar shqiptarët e vitit 2000 e tutje, është e rëndësishme të zbulosh kush kanë qenë ata gjatë viteve 1939-1945”, shkruan profesor Bernd Fischer në një nga librat e tij, duke dashur të evidentojë në këtë mënyrë sa rëndësinë, por dhe diskutimet e pranishme mbi këtë periudhë lidhur me krijimin e imazhit të shqiptarëve si popull dhe si shtet.Ky punim synon të sjellë nëpërmjet gjurmimit, analizës, krahasimit e shpjegimit në mënyrë shkencore, legjislacionin penal, por dhe më gjerë sistemin ligjor dhe gjyqësor shqiptar, nën ndikimin e rrethanave historike të kohës.
Një analizë kuantitative e viktimave të Prizrenit dhe rrethinës gjatë luftës së dytë botërore, sipas listës së viktimave të luftës, lëshuar nga Këshilli Ekzekutiv Federal i Jugosllavisë (Pjesa e dytë)
Authors: Limani Mrika
Published: March 2024

Në vazhdë të analizës së paraqitur paraprakisht, analiza e plotësuar është kryer duke u bazuar në fletushkat zyrtare të viktimave të Jugosllavisë të lëshuara nga Këshilli Ekzekutiv Federal i Jugosllavisë. Si pasojë, fletushkat për rrethinën e Prizrenit përmbajnë të dhënat mbi viktimat që kanë qenë qytetarë të regjistruar në komunën e Prizrenit, cilësi në bazë të cilës edhe janë regjistruar si viktima në rrethinën e Prizrenit. Ngaqë kjo ka qenë kriteri i seleksionimit për regjistrimin e viktimave, vendvdekja e një numri të konsiderueshëm të viktimave ka qenë jashtë kufijve të Kosovës. Megjithatë, me seleksionimin e të dhënave, analizës kuantitative
Zona operative e Shalës dhe veprimtaria e saj luftarake
Authors: Kurti Miftar
Published: March 2024

Ushtria Çlirimtare e Kosovës ishte njëra prej kryengritjeve më të suksesshme të periudhës pas Luftë së Ftohtë, edhe pse u formua për një kohë relativisht të shkurtër. Nacionalizmi e definoi betejën e saj. Ideologjia e saj ishte pothuajse kryekëput ideologji e nacionalizmit shqiptar2. Në vitin 1993 u krijuan rrethanat e mjaftueshme për krijimin e një organizmi ushtarak, që njihet si Ushtria Çlirimtare e Kosovës, kurse në vitin 1994 formohet Shtabi i Përgjithshëm (që ndryshe njihej si Shtabi Qendror) i saj, me seli në Prishtinë, në Lagjen Qendra të Prishtinës. Ky shtab kishte edhe objekte të tjera përcjellëse si në Kodrën e Diellit dhe në Dardani të Prishtinës. Në maj të vitit 1998, SHP formon të gjitha drejtoritë (G1-G9) përbërëse të Shtabit dhe merr formën komplete të tij që nga struktura komanduese e deri te çdo detaj përbërës i organizimit të shtabit.
Teuta Shala-Peli, “Drishti në Mesjetë”, Instituti i Historisë “Ali Hadri”-Prishtinë, Prishtinë 2016, 345 f.
Authors: Berisha Gjon
Published: March 2024

Në mesin e botimeve më të reja të studiuesve të Institutit të Historisë “Ali Hadri”, është vepra e dr. Teuta Shalës me përmbajtje specifike dhe të rëndësishme për historinë mesjetare shqiptare me titull “Drishti në Mesjetë”. Ky studim monografik që po i prezantohet lexuesit, ka për objekt studimi qytetin mesjetar të Drishtit, duke përfshirë aspekte të ndryshme të zhvillimit historik, shoqëror, ekonomik, kulturor, religjioz e politik të këtij qyteti, që nga koha e formimit si qytet e deri tek rënia e tij nën sundimin osman. Qëllimi i kësaj monografie, ashtu siç theksohet edhe nga autorja, është që të vë në pah rëndësinë dhe rolin e këtij qyteti mesjetar, si dhe transformimin e tij nga një qendër dikur e rëndësishme, në një fshat të harruar dhe të lënë nën mëshirën e fatit.
Sabit Syla, Shteti shqiptar dhe çështja e Kosovës 1939-1981, Instituti i Historisë “Ali Hadri”, Prishtinë, 2017, fq. 518
Authors: Basha Kosovar
Published: March 2024

Historiani Sabit Syla, kohë më parë botoi për herë të dytë monografinë e tij “Shteti shqiptar dhe çështja e Kosovës 1939-1981”. Libri në fjalë është një plotësim i variantit të parë, i cili u botua në vitin 2012. Të theksojmë se studimi në fjalë për herë të parë u mbrojt si disertacion doktorate në Tiranë gjatë vitit 2012. Autori për të finalizuar këtë libër hulumtoi dokumentacion arkivor në Arkivin Qendror të Shqipërisë, Arkivin e Ministrisë së Punëve të Jashtme, Arkivin e Ministrisë së Punëve të Brendshme, Arkivin e Kosovës, shtypin e kohës në Shqipëri dhe Kosovë si dhe literaturë relevante historiografike. Lënda burimore që parashtrohet në këtë studim ofron të dhëna të larmishme mbi

qëndrimet e shtetit shqiptar ndaj Kosovës gjatë viteve 1939-1981. Për dallim nga botimi i parë, autori ka plotësuar me fakte të reja dokumentuese rreth 100 faqe tekst mbi aspekte të ndryshme në rrafshim e politikës, pastaj në sferën e kulturës etj.
Kulti i Jupiter Dolichenus në Dardani
Authors: Hajdari Emine
Published: March 2024

Në territorin e Dardanisë, përmes burimeve epigrafike është dëshmuar prania e imigrantëve nga provincat lindore, të cilët përveçse si

përfaqësues të ushtrisë, si ndërmjetës të traditave orientale në zonën e artit dhe kulturës në përgjithësi, duhet parë edhe si tregtarë, skllevër, dhe mjeshtër të përpunimit të metaleve të ndryshme, me të cilat shquhet Dardania. Janë këto mënyrat, njerëzit dhe rrugët përmes të cilave kanë ardhur dhe janë përhapur edhe kultet e ndryshme në këtë rajon, në kohën kur ndikimi i orientit filloi të jetë i dukshëm pas krijimit të principatit dhe zgjerimit të territoreve të pushtuara nga Perandoria Romake. Në mesin e këtyre kulteve është ai i Jupiter Dolichenus, i cili ishte i ngjashëm me Jupiterin romak. Ai adhurohej jo vetëm në Dardani, por edhe në Mezinë e Epërme dhe më gjerë.
Situata politike dhe përshtypjet e të huajve mbi vilajetin e Kosovës gjatë vitieve 1880-ta
Authors: Bexheti Nuri , Islamaj Selver
Published: March 2024

Duke pasur parasysh rrethanat politike të kohës në vilajetin e Kosovës pas kryengritjes së madhe shqiptare të Lidhjes së Prizrenit, shihet

se asgjë nuk ka qenë e sigurt brenda kësaj hapësire. Nuk të garantohej jeta nëse ishe një personazh i fuqishëm i politikës së përditshme të kohës, ashtu siç ishte Ali Pashë Gusia, i cili e humbi jetën për shkaqe të konflikteve politike me “aleatë” të tij. Në anën tjetër na pasqyrojnë

tregimet dhe udhërrëfyesit e kohës gjendjen dhe rrethanat se si jetonin njerëzit dhe në cilin nivel ishte gjendja e sigurisë. Ata jepnin përshtypjet e tyre në detaj, që na mundëson të shohim edhe jetën sociale të kohës. Tregimet dhe raportet e konsujve të huaj adresojnë çështje të ndryshme, të cilat përfshijnë politikën ditore, jetën sociale, tregtinë, sigurinë në vend, e shumë aspekte tjera të cilat ishin me rëndësi për qeveritë e tyre, dhe që mund të na lehtësojnë qasjen më të detajuar të aspekteve të ndryshme të vilajeteve shqipfolëse, për të kuptuar edhe më mirë gjendjen politike dhe jetën sociale.
Shteti komunist dhe institucionet fetare në Shqipëri 1944-1949
Authors: Papagjoni Erjon
Published: March 2024

Raporti i shtetit komunist me komunitetet fetare në vitet 1944-1949 ka qenë i ndërlikuar, kufizues, diskriminues dhe shkatërrues, falë politikës sektare të ashpër e mohuese që regjimi komunist ndoqi ndaj tyre qysh në kryeherë. Një varg masash të rrepta u ndërmorën ndaj klerit të lartë dhe institucioneve fetare, të cilat u paraprinë nga akuzat politike, për t’u vazhduar më tej me masat ekonomike. Ata u akuzuan si tradhtarë, si

bashkëpunues me pushtuesin, si armiq të pushtetit e të rendit kushtetues.
Tarikati islam Saadi në qytetin e Gjakovës
Authors: Dobruna Alban
Published: March 2024

Është njëri prej tarikateve më të përhapur në trojet shqiptare në përgjithësi dhe në qytetin e Gjakovës në veçanti. Është rrugë brenda islamit, ku edhe ka zanafillën. Ky tarikat u themelua nga Sadedin Xhibaviu (1172- 1279), në fshatin Xhiba, në luginën e Haranit afër Damaskut.3 I ati i tij ishte Sheh Junuz Shebani El Huseini el Meki, i cili rridhte nga familja e Profetit Muhamed.
Sintomas somáticos funcionais em crianças atendidas na atenção primária à saúde
Authors: Do Prado Ana Paula , Pereira Padovani Flávia Helena
Published: March 2024

Os sintomas somáticos funcionais se caracterizam como manifestações de natureza principalmente somática e do comportamento da criança, sem causa orgânica aparente. Em um período em que a capacidade de comunicação verbal é, ainda, limitada, a criança utiliza meios de comunicação não-verbal, por meio de seu corpo. O presente estudo tem por objetivo verificar a prevalência de sintomas somáticos funcionais em crianças de 6 a 36 meses em acompanhamento na atenção primária. Trata-se de um estudo observacional, de corte transversal e abordagem quantitativa. Foi composta uma amostra de conveniência com 40 díades mãe-criança, tendo como critérios de inclusão: crianças com idade de 6 a 36 meses de idade, em seguimento pediátrico de rotina na Atenção Primária à Saúde e mães com 18 anos ou mais, que aceitaram participar do estudo, mediante assinatura do TCLE. Para a realização da pesquisa, foram aplicados os instrumentos Questionário Sociodemográfico, elaborado para o estudo e Questionário de Sintomas Somáticos do Bebê, em um único encontro, aproveitando a ida da mãe e da criança à unidade de saúde para acompanhamento pediátrico de rotina. Foram realizadas análises descritivas dos distúrbios de comportamento entre as crianças. Os resultados preliminares apontam que a maioria das mães (95%) avalia de forma positiva a saúde geral do(a) filho(a), porém aproximadamente um terço delas (30%) avaliaram a qualidade do sono da criança como razoável ou ruim, seguida por avaliações negativas de respiração (25%),  alimentação (22,5%), pele (20%), comportamento (15%) e digestão (10%). O estudo confirma a capacidade de identificação de sintomas somáticos funcionais na atenção primária à saúde.
Família e luto: revisando as contribuições empíricas entre 2010 e 2020
Authors: Sarturi Rigão Gabriela , Zink Leonardo , Dias Bornhorst Helena , Noronha Tusi Vitória , Da Rosa Olesiak Luisa , Rubin Rossato Pereira Caroline
Published: March 2024

Este estudo refere-se a uma revisão sistemática integrativa da literatura sobre as repercussões do luto de figuras do núcleo familiar, objetivando apresentar e discutir as características e resultados dos estudos empíricos sobre a temática. Os descritores “família” e “luto” foram utilizados para busca de artigos de acesso aberto publicados em inglês, português ou espanhol entre janeiro de 2010 e julho de 2020 em revistas indexadas nas bases PubMed, SciELO e PePSIc. Essa busca inicial resultou em 656 resultados, os quais foram selecionados pelos autores, para que cumprissem os requisitos de inclusão: ser artigos empíricos; ter como participantes famílias ou familiares enlutados; o luto ser referente à morte de uma pessoa da família; o estudo apresentar resultados sobre o luto da família. Assim, restaram 151 artigos, que foram analisados de forma descritiva quanto a escolhas metodológicas e quanto ao ano, país e revista de publicação. Os principais resultados apresentados dos estudos passaram por análise de conteúdo, sendo discutidos nas categorias: Repercussões fisiológicas do luto; Repercussões psicológicas e emocionais do luto; Vivências espirituais e ritualização na busca de significados à perda; Mudanças de comportamentos e nos relacionamentos familiares; Experiências de morte e comunicação com os profissionais de saúde; e Intervenções ao luto familiar. Observou-se a grande tendência do olhar individual para o luto mesmo quando a morte é de um membro da família, e a necessidade de ampliar a visão do luto enquanto uma vivência familiar.
The use of blockchain technology in law enforcement
Authors: Kiryushin Ivan Ivanovich , Ivanov Igor' Petrovich , Timofeev Viktor Vladimirovich , Zhmurko D Yu
Published: March 2024

This article explores the possibilities of using blockchain technology in police work. Examples of the use of blockchain in various areas of police activity, such as personal data management, control of drug trafficking and other prohibited substances, traffic monitoring and the fight against cybercrime, are considered. The authors note that thanks to the storage of data in the blockchain, it becomes possible to increase the protection of the confidentiality of personal information, ensure transparency and efficiency of police work, as well as prevent fraud and corruption. The conclusion of the article emphasizes that the use of blockchain can improve the work of the police and ensure greater security of citizens.   Distributed ledger technology, or blockchain as a service (BaaS) is indeed a relatively new product on the market that allows you to provide blockchain services for corporate clients. This solution allows you to use more reliable and secure methods of data processing and transaction management within the organization. All these economic effects can lead to a reduction in costs and an increase in the efficiency of the police. In general, the use of blockchain technology in the police can have a number of advantages, such as increasing transparency and accountability, reducing data processing time and combating data falsification. However, it is necessary to take into account some risks, such as the possibility of data privacy violations, as well as difficulties in integrating with existing systems and training personnel. In general, the introduction of blockchain technology into the police requires careful analysis and an approach that takes into account all aspects of the use of technology and its impact on the organization.
Thiophene-based N-phenyl pyrazolines: Synthesis, anticancer activity, molecular docking and ADME study
Authors: Chunaifah Istna , Venilita Riska Elya , Tjitda Putra Jiwamurwa Pama , Astuti Endang , Wahyuningsih Tutik Dwi
Published: March 2024

This investigation aimed to synthesize and evaluate the anticancer potential of thiophene-based N-phenyl pyrazoline derivatives containing methoxy groups using both in vitro and in silico assays. The N-phenyl pyrazolines were synthesized by reacting phenylhydrazine with chalcone derivatives. Using the 3-(4,5-dimethyl thiazole-2-yl)- 2,5-diphenyltetrazolium bromide (MTT) assay, we assessed the anticancer activity of the compounds that were synthesized in vitro against four human cancer cell lines (4T1 and T47D for breast cancer, HeLa for cervical cancer, and WiDr for colorectal cancer), as well as a normal cell line (Vero). The in silico evaluation was carried out through molecular docking and absorption, distribution, metabolism, and excretion (ADME) prediction. Among the synthesized pyrazolines, pyrazoline 2 was revealed as the most active anticancer against 4T1, HeLa, and WiDr cancer cell lines, with IC50 values of 9.09, 9.27, and 0.25 μg/ml, respectively. Furthermore, pyrazoline 2 showed high selectivity with selectivity index values of more than 6 toward all tested cancer cell lines. In silico evaluation via molecular docking against epidermal growth factor receptor revealed that pyrazoline 2 had the lowest binding energy with a value of 8.8 kcal/mol, which was consistent with experimental data. The ADME study using the pkCSM webtool indicated that the N-phenyl pyrazoline derivatives had good pharmacokinetic properties. Therefore, the results of this study suggest that thiophene-based N-phenyl pyrazoline derivatives containing methoxy groups, especially pyrazoline 2, could be potential anticancer agents.
Depredación sobre nidos, aves adultas y mamíferos por el lirón careto Eliomys quercinus
Authors: Gil-Delgado José A. , Tamarit Rosa , Viñals Adrià , Gómez Jaime , Vives-Ferrándiz Carmen
Published: March 2024

This study deals with birds and small mammals captured by the garden dormouse Eliomys quercinus in the orange groves of Sagunto (Valencia, E Spain). Samples come from exhaustive reviews of nest-boxes, but also of natural nests. Garden dormice predate on bird nests, containing eggs or nestlings, but also capture adults, even during the winter. Moreover, small mammals such as Mus and Crocidura were also captured, showing the abilities of this species to capture vertebrates
Interactions between circuit architecture and plasticity in a closed-loop cerebellar system
Authors: Payne Hannah L , Raymond Jennifer L , Goldman Mark S
Published: March 2024

Determining the sites and directions of plasticity underlying changes in neural activity and behavior is critical for understanding mechanisms of learning. Identifying such plasticity from neural recording data can be challenging due to feedback pathways that impede reasoning about cause and effect. We studied interactions between feedback, neural activity, and plasticity in the context of a closed-loop motor learning task for which there is disagreement about the loci and directions of plasticity: vestibulo-ocular reflex learning. We constructed a set of circuit models that differed in the strength of their recurrent feedback, from no feedback to very strong feedback. Despite these differences, each model successfully fit a large set of neural and behavioral data. However, the patterns of plasticity predicted by the models fundamentally differed, with the direction of plasticity at a key site changing from depression to potentiation as feedback strength increased. Guided by our analysis, we suggest how such models can be experimentally disambiguated. Our results address a long-standing debate regarding cerebellum-dependent motor learning, suggesting a reconciliation in which learning-related changes in the strength of synaptic inputs to Purkinje cells are compatible with seemingly oppositely directed changes in Purkinje cell spiking activity. More broadly, these results demonstrate how changes in neural activity over learning can appear to contradict the sign of the underlying plasticity when either internal feedback or feedback through the environment is present.
Emergence of ion-channel mediated electrical oscillations in Escherichia coli biofilms
Authors: Akabuogu Emmanuel U. , Martorelli Victor , Krašovec Rok , Roberts Ian S. , Waigh Thomas A.
Published: March 2024

Bacterial biofilms are communities of bacteria usually attached to solid strata and often differentiated into complex structures. Communication across biofilms has been shown to involve chemical signaling and, more recently, electrical signaling in Gram positive biofilms. We report for the first time, community-level synchronized membrane potential dynamics in three-dimensional
E. coli
biofilms. Two hyperpolarization events are observed in response to light stress. The first requires mechanically sensitive ion channels (MscK, MscL and MscS) and the second needs the Kch-potassium channel. The channels mediated both local spiking of single
E. coli
biofilms and long-range coordinated electrical signaling in
E. coli
biofilms. The electrical phenomena are explained using Hodgkin-Huxley and 3D fire-diffuse-fire agent-based models. These data demonstrate that electrical wavefronts based on potassium ions are a mechanism by which signaling occurs in Gram negative biofilms and as such may represent a conserved mechanism for communication across biofilms.
Epigenetics and chromatin structure regulate var2csa expression and the placental binding phenotype in Plasmodium falciparum
Authors: Lenz Todd , Sirel Madle , Hoppe Hannes , Shafeeq Sulman , Roch Karine Le , Ribacke Ulf
Published: March 2024

Plasmodium falciparum
is responsible for what appears to be a never-ending public health issue in the developing world. With repeated infections, a gradual semi-immunity to severe malaria can be acquired but this is disrupted when women become pregnant as the parasite cytoadheres in the placenta to prevent splenic clearance. This change in tissue tropism is due to specific expression of the antigenically variable adhesin VAR2CSA. To better understand the molecular mechanisms activating
var2csa
and antigenic variation over all, we used a combination of phenotypic and systems biology assays. We first established phenotypically homogenous populations of VAR2CSA expressing and placenta binding parasites that were shown to exclusively transcribe
var2csa
while all other
var
genes remained silenced. We also confirmed that the transcriptional activation was strongly associated with distinct depletion of repressive H3K9me3 marks. Further, we used chromatin conformation capture as a high-resolution approach to determine interchromosomal interactions and established that transcriptional activation is linked to a small yet significant repositioning of
var2csa
relative to heterochromatic telomeric clusters. Lastly, we demonstrated that occupancy of 5-methylcytosine was present in all
var
genes but independent of transcriptional activation and switching. All together, these findings provide insights at high resolution into the potential role of 5-methylcytosine in
P. falciparum
and increase our understanding of the mechanisms regulating antigenic variation at the epigenetics and chromatin structure level.
Research overview on the genetic mechanism underlying the biosynthesis of polysaccharide in tuber plants
Authors: Xu Mengwei , Hu Jiao , Li Hongwei , Li Kunqian , Xu Delin
Published: March 2024

Tuber plants are of great significance in the world as human food crops. Polysaccharides, important metabolites in tuber plants, also serve as a source of innovative drugs with significant pharmacological effects. These drugs are particularly known for their immunomodulation and antitumor properties. To fully exploit the potential value of tuber plant polysaccharides and establish a synthetic system for their targeted synthesis, it is crucial to dissect their metabolic processes and genetic regulatory mechanisms. In this article, we provide a comprehensive summary of the basic pathways involved in the synthesis of various types of tuber plant polysaccharides. We also outline the key research progress that has been made in this area in recent years. We classify the main types and functions of tuber plant polysaccharides and analyze the biosynthetic processes and genetic regulation mechanisms of key enzymes involved in the metabolic pathways of starch, cellulose, pectin, and fructan in tuber plants. We have identified hexokinase and glycosyltransferase as the key enzymes involved in the polysaccharide synthesis process. By elucidating the synthesis pathway of polysaccharides in tuber plants and understanding the underlying mechanism of action of key enzymes in the metabolic pathway, we can provide a theoretical framework for enhancing the yield of polysaccharides and other metabolites in plant culture cells. This will ultimately lead to increased production efficiency.
High-resolution density assessment assisted by deep learning of Dendrophyllia cornigera (Lamarck, 1816) and Phakellia ventilabrum (Linnaeus, 1767) in rocky circalittoral shelf of Bay of Biscay
Authors: Gayá-Vilar Alberto , Cobo Adolfo , Abad-Uribarren Alberto , Rodríguez Augusto , Sierra Sergio , Clemente Sabrina , Prado Elena
Published: March 2024

This study presents a novel approach to high-resolution density distribution mapping of two key species of the 1170 “Reefs” habitat, Dendrophyllia cornigera and Phakellia ventilabrum, in the Bay of Biscay using deep learning models. The main objective of this study was to establish a pipeline based on deep learning models to extract species density data from raw images obtained by a remotely operated towed vehicle (ROTV). Different object detection models were evaluated and compared in various shelf zones at the head of submarine canyon systems using metrics such as precision, recall, and F1 score. The best-performing model, YOLOv8, was selected for generating density maps of the two species at a high spatial resolution. The study also generated synthetic images to augment the training data and assess the generalization capacity of the models. The proposed approach provides a cost-effective and non-invasive method for monitoring and assessing the status of these important reef-building species and their habitats. The results have important implications for the management and protection of the 1170 habitat in Spain and other marine ecosystems worldwide. These results highlight the potential of deep learning to improve efficiency and accuracy in monitoring vulnerable marine ecosystems, allowing informed decisions to be made that can have a positive impact on marine conservation.
Endovascular Treatment of Aneurysms with Complex Aortic Anatomy
Authors: Ferreira Luis Mariano , Ferrer Miguel , Aloy Leonela , Dávila Vázquez Oscar Marcelo , La Mura Ricardo
Published: March 2024

Background: Arterial anatomy is the main limiting factor for standard endovascular aortic (EVAR) approach. We present our experience for endovascular repair of complex aortic aneurysms. Methods: This is a retrospective observational study in patients with complex aneurysms (juxta/pararenal and thoracoabdominal) treated consecutively with: fenestrated (FEVAR), branched (BEVAR), EndoAnchors (ESAR), or chimney (ChEVAR) stents. The decision of the technique was determined based on the arterial anatomy. Results: The last 50 procedures were evaluated (6 women; mean age 71.3 years; diameter 69.6 mm; and 3 patients with complicated aneurysms), among whom 22 received FEVAR (2.8 fenestrated stents/patient), 11 BEVAR, 11 ESAR and 6 ChEVAR (1.8 chimney stents/patient). Technical success rate was 100% (absence of type I or III endoleak with adequate patency of the visceral vessels). Three patients died within the first 30 days (6%). During follow-up, 5 patients presented with renal artery occlusion, treated successfully in 4 cases. Four patients developed type IA endoleak (3 secondary ESAR and one ChEVAR), one patient IC endoleak and almost a quarter of cases type IIIB endoleak (22%, 3 out of 11 patients receiving ESAR, none of the industrial FEVAR group). Overall survival was 88.6% at one year, and 86.5% of cases were free from reoperation. Conclusions: This is the first publication in our setting that shows a global approach to the patient with complex aortic aneurysm, according to the anatomical characteristics. These technologies already play a primary role in the treatment of these patients.
Impact of a Heart Team in patients with aortic stenosis who are candidates for transcatheter aortic valve replacement
Authors: Trivi Marcelo , Castro María F. , Trossero Romina , Cura Fernando A. , Piccinini Fernando , Candiello Alfonsina , Lamelas Pablo , Henquin Ruth , Botto Fernando , Ronderos Ricardo
Published: March 2024

As transcatheter aortic valve implantation (TAVI) for aortic stenosis (AS) became widespread, there arose the need for a Heart Team (HT) to choose the best treatment. There are few reports as regards its usefulness. Objectives: To analyze treatment outcomes in patients with AS evaluated by a HT for 10 years. Methods: Consecutive enrollment of all patients with AS who were candidates for TAVI between January 2012 and July 2021 to choose the best treatment, including surgical aortic valve replacement (SAVR) and conservative medical management (CMM). Results: Out of 841 patients, 455 were assigned to TAVI (53%), 213 to SAVR (24%), and 183 to CMM (23%). The percentage assigned to TAVI has increased from 48% to 62% over time (p <0.05). Patients who underwent TAVI versus those who underwent SAVR were older (86 ± 7 vs. 83 ± 7 years), had a higher EUROSCORE II (6.2, 95% CI 5.7-6.6 vs. 5.6; 95% CI 4.4-6.5) and were frailer (1.62 ± 1 vs. 0.91 ± 1) in all cases (p <0.01). Actuarial survival (95% CI) at 1 and 2 years was 88% (84-91%) and 82% (77-86%) for TAVI, 83% (76-88%) and 78% (70-84%) for SAVR, and 70% (60-87%) and 59% (48-68%) for CMM, respectively (p <0.001). Conclusions: For the first 10 years after a Heart Team was established for AS decision-making, approximately half of the patients were assigned to TAVI, and the rest were equally assigned in halves to either surgery or observation. Survival for patients who received interventions was similar at 2 years and higher than in those who did not.
Cardiogenic Shock in the Setting of Acute Coronary Syndromes in Argentina: Results from the ARGEN SHOCK 2 Registry
Authors: Castillo Costa Yanina , Delfino Flavio , Mauro Víctor , Barrero Carlos M. , García Aurelio Mauro , D´Imperio Heraldo , Macin Stella Maris , Villarreal Ricardo , Souto Juan , Frontera Esteban
Published: March 2024

Background: Cardiogenic shock (CS) is a life-threatening complication of acute myocardial infarction (AMI) and constitutes one of the leading causes of death. Objective: The aim of this study was to investigate the clinical characteristics, treatment strategies, hospital outcome and 30-day mortality of CS in Argentina. Methods: We conducted a prospective, and multicenter registry of patients with acute coronary syndromes (ACS) with and without ST-segment elevation complicated with CS that were hospitalized in 23 centers in Argentina for 14 months (between August 1, 2021, and September 30, 2022). Results: The cohort was made up of 114 patients; median age was 64 years (58-73) and 72% were women; 76.3% corresponded to ST-segment elevation ACS, 12.3% to non-ST-segment elevation ACS, 7% had right ventricular infarction and 4.4% had mechanical complications. In 66.6% of cases CS was present on admission. Revascularization: 91.1%, use of inotropic agents: 98.2%, mechanical ventilation (MV): 59.6%, Swan-Ganz catheter: 33.3%, intra-aortic balloon pump: 30.1%. Overall in-hospital mortality was 60.5%, with no differences between ACS with or without ST-segment elevation, and was 62.6% at 30 days. Conclusion: Morbidity and mortality of CS are high despite the high rate of reperfusion therapy used.
What Are We Talking About When We Talk About Palliative Care in Heart Failure?
Authors: Sánchez Mariángel , Proasi Francisco , Ahualli Luis , Higa Claudio
Published: March 2024

Background: Heart failure is a chronic, complex and progressive disease, with high morbidity and mortality, and growing prevalence. Despite advances in therapeutic strategies to improve survival and reduce hospitalizations, heart failure still generates a negative impact on the patients’ quality of life, making it necessary to develop health policies based not only on their physical but also on their psychosocial integrity. Palliative care refers to specialized, interdisciplinary care focused on improving the quality of life of patients who suffer a disease with elevated morbidity and mortality. The aim of this review is to assess the impact of the implementation of palliative care in the multidisciplinary treatment of heart failure throughout all the stages of the disease, and to determine the feasibility of its application in clinical practice.