bluuebunny/crossref_metadata_2025 huggingface dataset:
Frida Kahlo w perspektywie polityczności
Authors: Ozimek Magdalena
Published: March 2022

Paper is about Frida Kahlo. This mexican painter is mainly known as Diego Rivera’s wife, famous muralist, or woman having an affair with Leon Trotsky. It leaves out her political stance, which materialized in her art, but also in for example in her educational practice. Due to the political category you can highlight this political items. Relational marked of this category, leads to notice the key context, which was the mexican revolution, which agenda explain the political of interdependent sphere of politcs, including art and social engagement of F. Kahlo.
Być po stronie wykluczonych – Izabela Filipiak (Izabela Morska)
Authors: Baniecka Ewa
Published: March 2022

Izabela Filipiak, as a one of the first authors in free Poland, undertook a creation of a narrative of the other, and took the perspective of the excluded. In a famous novel from 1995 entitled “Absolute amnesia”, which hangs over on the motive of maturation, she narrated about the peace of history of the PRL (Polish National Republic), which relates to the events in the coastal area of Gdańsk in 1970, seen with eyes of a young girl, who considered the reality of those times on her own. Surely Izabela Filipiak can be regarded as a representative of the nowadays fashionable and readily practiced herstory. She developed further this trend in her writings consequently, at the level of the methadiscourse in her textbook-essay: “Creative writing for the young girls” and also in a discourse devoted to Maria Komornicka, entitled: “Areas of difference”. A monograph, as formulated in a review by Krystyna Kłosinska, is a place from which the cultural mechanisms of the exclusion can be seen. Izabela Filipiak shows a rebellious attitude toward a discourse which implements a symbolic violence, based on awarding a right to a majority, only because it is a majority. She takes a part of the excluded both with her writings and her own biography (she was 1998 the first known person in a polish public life, who decided for coming out and publicly disclosed her lesbian sexual orientation). She had been also a president of the antidiscrimination Foundation of Writers for the peace, which declared “initiation and support of the creative activities of people belonging to minority groups”. In this sense Izabela Filipiak can be out of doubt regarded as defiant and a person who attempt to deconstruct the present system of standards, as far as such issues are concerned as a gender and sexuality. She is a feminist, an essential personage for the polish gender studies. Izabela Filipiak represents the writer (innovator and apocrypha author), the publicist and the scientist. With her creation, she contributed to the development to the polish queer studies. For her opposition to the exclusion of the other she paid a high price and had decided to leave temporarily the country and to live as emigrant.
CENA DE CAÇA NA CAVERNA DE LASCAUX: PROJETO PARA O FUTURO E AUTORRECRIAÇÃO HUMANA
Authors: Da Conceição Garcia Claudia , Coutinho Luciano
Published: March 2022

A expressão desenho, neste artigo, está associada à expressão projeto, como um impulso para uma existência futura desejada, que não pode ser simplificada em uma noção rasa de dominação, mas antes precisa ser expandida para um princípio de autorreconhecimento e de autorrecriação do próprio humano. Com o objetivo de situar esse entendimento, buscamos  demonstrar como isto acontece desde a pré-existência da nossa humanidade, analisando uma cena de caça da caverna de Lascaux. Pretendemos, portanto, demonstrar como a autoconsciência do homem pré-histórico foi capaz de projetar um vir-a-ser a partir de escolhas estéticas que recriaram e direcionaram a autoimagem da própria humanidade diante das intempéries e do desejo de dominação da natureza.
Health-related Quality of Life and Domain-specific Associated Factors among Patients with Type2 Diabetes Mellitus in South India
Authors: Natarajan Jansirani , Mokoboto-Zwane Sheila
Published: March 2022

OBJECTIVE: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that has a major impact on health-related quality of life (HRQOL). The economic burden of the disease, along with its complications, negatively impact the individual, family, and society of Indian diabetic
patients. This study explored the perception of the diabetic HRQOL of South Indian type2diabetic patients. METHODS: This study was a cross-sectional descriptive quantitative study conducted in a tertiary care hospital in Chennai, Tamil Nadu, South India. Using the simple random sampling
technique, we collected data from 352 T2DM patients aged ≥ 30 years of age who were diagnosed for a minimum of one year. Data collection occurred from June to August 2017. Data were analysed using IBM SPSS, Version 22. RESULTS: Overall, 90% of patients with T2DM perceived poor HRQOL.
The total and the domainspecific mean scores of HRQOL were high indicating poor HRQOL in energy mobility, diabetes control, anxiety and worry, social burden, and sexual functioning domains. Being female, increasing age, lower education levels, lower family income, and uncontrolled fasting
blood glucose levels predicted poor HRQOL of patients with T2DM. CONCLUSIONS: T2DM impacted the HRQOL in all measured domains of participants. A patient-centred approach to diabetes management can be incorporated to improve or enhance the health-related quality of patients' lives. Improved
HRQOL also may lead to fewer hospitalizations, and hence, reduce healthcare costs.
Antioxidant Activity and Bioactive Compounds of Ethyl Acetate Fractions from Syzygium cumini Wood Stem
Authors: Alawiyah Aika Latifah , Senania Astri
Published: March 2022

Syzygium cumini is one of the endemic plants in Indonesia that has the potential to be developed. The fruit was known to have potential as a diabetes drug. However, very few studies to determine the medicinal potential and identification of compounds of Syzygium cumini wood stem has never been studied before. Therefore, this study aimed to determine the antioxidant activity and content of compounds in Syzygium cumini wood stem ethyl acetate fraction. The crude ethanol extract was prepared from the wood stem powder of Syzygium cumini in ethanol using maceration. Furthermore, it was carried out by the liquid-liquid fractionation process using solvents of different polarity. Antioxidant activity of the crude extract, hexane fraction, and ethyl acetate fraction was determined by spectrophotometric methods using 1,1-diphenyl-2-picrylhydrazyl (DPPH). Analysis of bioactive compounds by using Thin Layer Chromatography (TLC). Identification of compounds functional groups was carried out to support the results of TLC analysis by using Fourier-transform infrared (FTIR). Ethyl acetate fraction showed the highest antioxidant activity (IC50 13,62 µg/mL), followed by ethanol extract (IC50 19,64 µg/mL) and hexane fraction (IC50 61,25 µg/mL). The antioxidant activity of the acetate fraction was lower than that of ascorbic acid with an IC50 value of 2,85 µg/mL. However, this fraction has very strong antioxidant activity. The TLC analysis results showed that the sample was thought to contain an alkaloid, phenolic, flavonoid, and terpenoid. The assumption on agreement with FTIR analysis which showed functional groups were C-H, O-H, N-H, C=O, and C=C aromatics as constituents of these compounds.
Dye Sensitized Solar Cell Using Extract from Red and Yellow Four O’clock Flowers (Mirabilis jalapa)
Authors: Hamdani Mochammad Luthfi
Published: March 2022

Four o’clock flowers contain betalain compound namely betacyanin and betaxanthin. This compound is used as sensitizer on dssc. This study used water as a solvents with pH variations of 2, 4, and 6 for the extraction of betalain compounds from four o'clock flowers. Molecular characterization of compounds using Uv-Vis spectrophotometer to determine the wavelength and FTIR to determine the functional groups. The HOMO and LUMO analysis using a Cyclic Voltametery. This study generated absorbance to red and yellow four o'clock flowers extract is 532.50 nm which is betacyanin and 473.30 nm which is betaxanthin. FTIR analysis both of dyes produce wave number 3750-3000 cm-1 showed the presence of hydroxyl (O-H) and 1675-1500 cm-1, which showed the presence of alkenes. The HOMO and LUMO analysis using cyclic voltammetry of betacyanin extract at pH 2 were -3,497 eV and -6,012 eV and betaxanthin were -3,623 eV and -5,803 eV. DSSC performance using betacyanin and betaxanthin dye showed an efficiency value of 0.208% and 0.0036%. Results showed that the extract betacyanin and betaxanthin of red and yellow four o'clock flowers have shown a good sensitizer agents in DSSC.

Keywords: Betacyanin, Betaxanthin, DSSC, Efficiency
Determination of Mefenamic Acid and Dexametashone in Instant Pegal Linu Herbal Medicine in Kediri by Using UV-Vis Spectro
Authors: Sukmawati Datin An Nisa , Sembiring Yulia Shara
Published: March 2022

Jamu pegal linu is one of the traditional medicinal products that are in great demand by the public, because it can relieve muscle and bone pain, improve blood circulation, strengthen body resistance, and relieve pain all over the body. However, some industry players have added medicinal medicine such as dexamethashone and mefenamic acid in herbal medicine. This study aims to determine the validity of the method in the analysis of dexamethashone and mefenamic acid by UV-Vis spectrophotometry on herbal medicine circulating in Indonesia several markets in Kediri-East Java. The sampling technique used in this study is a purposive sampling method so as to get 5 samples of herbal medicine (A,B,C,D,E). Research begins with determined of wavelength (nm) maximum of dexamethashone and mefenamic acid standard at 200-400 nm and determined of method validation to ensure the accuracy of the method in determining dexamethashone and mefenamic acid levels in the sample. The results of the research showed that the wavelength maximum of mefenamic acid and dexamethashone standard were 288 nm and 245 nm. The method validation showed that this method is good for detect the presence of mefenamic acid and dexamethasone in herbal medicine with the value of the validation parameters, such as linierity of calibration curve of mefenamic acid and dexamethasone weas 0.998, detection limit (LOD) 0.8779 µg/mL and 0.9677 µg/mL ; quantification limit (LOQ) 2.9264 µg/mL and 2.2256 µg/mL; intraday and interday precision of mefenamic acid was expressed by the value of % standard deviation relative (%RSD) was 0.8905 % and 1.0781 %; intraday and interday precision of dexamethasone was expressed by the value of % standard deviation relative (%RSD) was 0.6917 % and 0.8062 %. Respectively; as well as the accuracy expressed in mean % recovery were 101.547 % for mefenamic acid, and 100.576% for dexamethasone. Results analysis of the sample using a validated method showed that only sample A was mefenamic acid positively with concentration was 7.6796 µg/mL. The other hand, sample C,D and E was dexamethashone positively with concentrations were 2.4978 µg/mL, 2.4112 µg/mL and 8.7748 µg/mL.
Gaya Kepemimpinan KH. Dainawi Gerentam Bumi Dalam Membentuk Karakter Moderasi Beragama Di Pondok Pesantren Al-Haromain
Authors: Ferdian Ilham
Published: March 2022

Pola kepemimpinan yang dilakukan oleh K.H. Dainawi Gerentam Bumi Dalam Membangun Karakter Moderasi beragama yaitu teladan wibawa seorang kiyai di pesantren dijunjung tinggi oleh iklim sosial tempat tinggalnya sehingga begitu menonjol dalam kehidupan Pondok Pesantren Al_Haromain. Untuk menganalisis hasil penelitian penulis menggunakan teori kepemimpinan. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif. Dengan menggunakan sumber data primer nya yaitu observasi dan wawancara, sedangkan data sekunder yaitu diperoleh dari hasil dokumentasi, buku-buku, jurnal, dan laporan lainnya dari hasil penelitian yang terkait.

Hasil penelitian ini ditemukan, bahwa Gaya Kepemimpinan K.H. Dainawi Gerentam Bumi Dalam Membentuk Karakter Moderasi Beragama Diruang Lingkup Santri Dan Masyarakat Pondok Pesantren Al-Haromain yaitu bahwa kita dapat melihat dari bagaimana gaya kiyai memimpin, otoritas seperti apa yang menggambarkannya dan model pemerintahan seperti apa yang dia gunakan, sehingga dengan menyelidiki gaya, tipe dan model kepemimpinan kiyai. Inisiatif, contoh pemerintahannya dapat diakui, Adapun yang menjadi Korelasi Serta Aktivitas Moderasi Beragama Pada Zaman Sekarang yaitu Hubungan pengendalian di madrasah Al-Haromain dapat dilihat melalui keragaman informasi (tepat). Untuk berbagai informsi, kami dapatkan melalui pertanyaan-pertanyaan dalam survei yang kami sebarkan. Selain itu Keterlibatan Kiyai Dalam Penerapan Moderasi Beragama Di Lingkungan Pondok Pesantren Al-Haromain yaitu dalam membangun pengawasan yang ketat dalam iklim sekolah islam Al-Haromain, Kiyi menerapkan kerangka instruksional dan peragaan yang di dalamnya terdapat 3 contoh, yaitu rancangan pengasuhan khusus, rancangan peragaan, dan rancangan santri dalam membangun serta membentuk karakter moderasi beragama yang dilakukan di Pondok Pesantren Al-Haromain dengan K.H. Dainawi Gerentam Bumisebagai pemimpin sekaligus pengasuh yayasan Pondok Pesantren Al-Haromain yang terletak di wilayah Kec. Semende Darat Laut Kab. Muara Enim yang peneliti gunakan sebagai objek penelitian.
Persepsi Masyarakat Plaju Palembang Terhadap Partai Politik Islam
Authors: Juliani Resti
Published: March 2022

penelitian ini bertujuan untuk mengetahui bagaimana persepsi masyarakat kelurahan plaju ulu terhadap partai politik islam dan untuk mengetahui apa yang melatrbelakangi terbentuknya persepsi masyarakat keluruhan plaju ulu.
Strategi Politik Pemanfaatan Kelompok Tani di Banyuasin Dalam Pileg 2019
Authors: Raini Yeni Angg
Published: March 2022

Nama : Yeni anggraini NIM : 1720404031Fakultas : Adab dan HumanioraProdi/Tahun : Politik Islam/2017 Judul Skripsi : Strategi Pemanfaatan Kelompok Tani Dalam Pemenangan Damsih S.H Pada Pileg 2019 Di Kabupaten Musi Banyuasin

Srategi merupakan pendekatan secara keseluruhan yang berkaitan dengan pelaksanaan gagasan, perencanaan dan eksekusi sebuah aktivitas dalam kurun waktu yang telah ditentukan. Di dalam startegi yang baik terdapat koordinasi kerjasama tim dengan memiliki tema mengidentifikasikan faktor pendukung yang sesuai dengan prinsip-prinsip pelaksanaan gagasan secara rasional, efisien dalam pendanaan serta memiliki taktik untuk mencapai tujuan tertentu. Secara efektif strategi komunikasi politik yang dilakukan oleh Calon Legislatif (caleg) terhadap masyarakat sangat diperlukan dalam menghadapi sebuah pemilihan legislatif. Mak penulis mengambil sebuah penelitian dengan tema strategi pemanfaatan Kelompok Tani Dalam pemenangan DAmsih S.H PAda Pileg 2019 di Kabupaten Musi Banyuasin. Rumusan masalah dalam penelitian ini adalah bagaimana terbentuknya serta pemanfaatan Kelompok Tani dalam Politik dan juga Bagaimana Damsih S.H mengelolah Jaringan Akar Rumput Sehingga menjadi moda Kemangan?. kemudian penelitian ini bertujuan untuk melihat strategi komunikasi yang di gunakan damsih guna mempertahankan suara di masyrakat dengan cara memanfaatkan Kelompok Tani sebagai Tim sukses pada saat Pileg 2019. Metode penelitian yang di gunakan dalam penelitian ini adalah pendekatan kialitatifmelalui analisis deskriptif, dokumentasi dari hasil Observasi dan wawancara dengan praktis, pengamat,dan penelitian di bidang yang berkaitan dengan penelitian ini.Penelitian ini menemukan hasil dengan kesimpulan bahwa Proses terbentuk hubungan politik antara Damsih Dan Kelompok tani pada saat pileg 2019 melalui proses pendekatan dan pemahaman terhadap kondisi di sekitar Dapil (daerah pilih) serta pemahaman terhadap lokasi dan kebutuhan masyarakat kemudian bantuan yang memang di berikan kepada kelompok tani. Bentuk stategi Damsih dalam mengelola Kelompok tani sehingga menjadi modal kemenangan di lihat dari latar belakang masyarakat Musi Banyuasin yang 60% merupakan petani serta tingkat kejujuran petani yang lebih besar menjadi poin utama Damsih menjadikan kelompok tani sebagai tempat untuk memperoleh kemenangan dengan ini dengan dua poin utama bagaimana Damsih mengelola kelompok tani sehingga menjadi modal kemenangan yakni, dengan cara kelompok tani di jadikan modal untuk bersosialisasi di masyarakat serta dengan menjadikan kelompok tani sebagai tim sukses atau tim kemenagan.Kata Kunci : Strategi komunikasi Politik,Pileg, Kelompok Tani
KARAKTERISTIK PEDAGANG PISANG DI PASAR WATES WETAN KECAMATAN RANUYOSO KABUPATEN LUMAJANG
Authors: Masyita Syifani Putri , Sofia Sofia
Published: March 2022

Wates Market Wetan is one of the markets that has a lot of banana trading activity. The dense trading activity at Wates Wetan Market has caused congestion on the roads of Probolinggo and Lumajang Regencies. This study aims to determine the characteristics of banana traders in Wates Wetan Market, Ranuyoso District, Lumajang Regency. The research method used is a qualitative method. The research location was determined purposively, namely in Wates Wetan Market. Determination of informants was done through purposive sampling then snowball. Data collection techniques by means of interviews, observation and documentation. The data analysis method used the interactive model of Miles and Huberman. The validity of the data used source triangulation and technique triangulation. The results showed that: the characteristics of banana traders were divided into two, namely internal characteristics and external characteristics. The internal characteristics found in banana traders in Wates Wetan Market include banana traders who are at the productive age for work, low education level, have 3-6 family dependents, in general banana traders at Wates Wetan Market are male. The external characteristic of banana traders at Wates Wetan Market is that banana traders are mostly collectors and some are wholesalers. Banana traders make trading bananas their main job. The types of bananas that are traded are various, such as Raja Banana, Mas Banana, Raja Jackfruit Banana, Barlin Banana, Kepok Banana, Milk Banana, Ambon Banana, Green Banana and Embuk Banana. Banana traders usually come during the market, but there are also banana traders who come every day at Wates Wetan Market, generally they come from early morning. Most of the banana traders use motorbikes to come to the Wates Wetan Market.

Keywords: Characteristics, traders
Consulta Não Presencial no Serviço Nacional de Saúde Português Durante a Pandemia de COVID-19: Estudo da Opinião dos Médicos e Implicações para o Futuro
Authors: O'Neill Catarina , Matias Margarida V. , Peixoto Vasco R. , O'Neill Henrique , Aguiar Pedro , Castela Eduardo
Published: March 2022

Introdução: A pandemia de COVID-19 impôs uma reorganização dos serviços de saúde e a teleconsulta surgiu como solução para manter o acompanhamento dos utentes. Este estudo caracterizou, pela perspetiva dos médicos, a consulta não presencial (CNP) realizada no Serviço Nacional de Saúde (SNS) durante a primeira fase da pandemia e identificou fatores que influenciam a experiência da consulta.Material e Métodos: Estudo transversal analítico com base num questionário online dirigido aos médicos do SNS entre julho e setembro de 2020. Recolheram-se dados demográficos e informação sobre a prática, atitudes e perceções relativas à CNP. Foram calculadas razões de prevalência através de regressões Poisson, ajustadas para identificar fatores associados a maior satisfação, utilização de videochamada e maior motivação para realizar teleconsultas no futuro.Resultados: Obtiveram-se 2225 respostas válidas. A CNP foi realizada por 93,8% dos inquiridos neste período, dos quais 99,0% utilizou o telefone como forma de comunicação e apenas 8,0% a videochamada. Registámos elevada satisfação com as CNP realizadas, com significativa associação à ideia de que a CNP providencia cuidados de saúde de qualidade equivalentes à consulta presencial [adjusted prevalence ratio (aPR) = 1,472], e adesão à realização de CNP após a pandemia (aPR = 4,081). A existência de dificuldades clínicas (aPR = 0,763) ou técnicas (aPR = 0,666) esteve associada a menor satisfação. Entre os médicos respondentes, 70,4% gostariam de continuar a realizar CNP subsequentes e 53,3% consideram que deve ser sempre ou muitas vezes utilizado suporte de vídeo na CNP.Conclusão: A teleconsulta parece ter potencial para se tornar uma prática comum no futuro. No entanto importa solucionar limitações de natureza clínica, técnica, organizacional e legal e, assegurar que é uma prática segura, benéfica e valorizada pelo utente.
Composite of Polylactic Acid/Chitosan/Ag-Hydroxyapatite Synthesized Using Turmeric Leaves Extract-Mediated Silver Nanoparticle and Snail Shell as Antibacterial Material
Authors: Audita Rahmania , Khoirunisa Khoirunisa , Azzahra' Hasna' Azizah , Nugroho Bambang Hernawan , Hidayat Habibi , Fatimah Is
Published: March 2022

The development of an antibacterial composite of polylactic acid/chitosan/silver nanoparticle-doped hydroxyapatite has been synthesized. The composite was prepared using the silver nanoparticles (AgNPs) green synthesized by using turmeric (Curcuma longa Linn) leaves extract-mediated AgNPs and snail shell as biogenic calcium for hydroxyapatite synthesis. The precipitation method of hydroxyapatite by the doping of AgNPs was the first step, followed by composting with polylactic acid and chitosan as the polymer binder. Physicochemical characterization of the material was studied by using XRD, SEM, and FTIR analyses, and the antibacterial catalytic performance was examined against Escherichia coli (E. coli). The results showed that the synthesized AgNPs are within the <100 nm range in size and not significantly influence the crystallinity of the Ag/HAp. The composite materials maintained the antibacterial activity against E. coli.
Preparation of Low-cost Adsorbent Based on Mango Leaf (Mangefira Indica L) Biomass for Methylene Blue (MB) Adsorption
Authors: Musawwa Muhammad Miqdam , Fajriati Annisa , Sahroni Imam , Said Ahmad
Published: March 2022

Preparation of leaf mango (Mangefira Indica L)-based adsorbent and its evaluation to reduce methylene blue (MB) concentration have been conducted. Two materials: ads-pristine and ads-CTAB which are referred as native leaf mango adsorbent and CTAB modified leaf mango have been prepared in this study. Cetyltrimethylammonium bromide (CTAB) is cationic surfactant usually used to modify and increase the surface area of the adsorbent for a specific purpose. The materials obtained were characterized by the Fourier Transform Infra-Red (FTIR) and the Scanning Electron Microscope (SEM) with general result, there were detected functional groups indicated the active sites on the adsorbent such as -OH, C-O, C=C. Ads-CTAB was specifically characterized with appearing of C-H aliphatic as the tail of CTAB molecule. SEM images show that both materials have roughness surface and irregular cavities. Additional of CTAB on the surface led the more regularly surface. The optimum pH was in basic region (8), while the optimum adsorbent mass and MB concentration are not clearly found due to the chart still increasing. However, the highest qe was found by 0.01 g of ads-pristine and ads-CTAB with the value 967.25 and 950.75 mg g-1 respectively. As the further evaluation, with the 0.5 adsorbent mass it may be applicated on the MB concentration at around 4000 mg L-1. Kinetics model of this adsorption was followed pseudo second order reactions.
Exosomal miR-155 from gastric cancer induces cancer-associated cachexia by suppressing adipogenesis and promoting brown adipose differentiation via C/EPBβ
Authors: Liu Ying , Wang Meng , Deng Ting , Liu Rui , Ning Tao , Bai Ming , Ying Guoguang , Zhang Haiyang , Ba Yi
Published: March 2022

Objective: The aim of this research was to identify whether exosomes were involved in impairing adipogenesis in cancer-associated cachexia (CAC) by detecting the adipodifferentiation capacity and the expressions of adipogenic proteins in gastric cancer (GC)-associated adipocytes. Methods: Western blotting and RT-PCR were used to investigate the expressions of C/EPBβ, C/EPBα, PPARγ, and UCP1 in adipose mesenchymal stem cells (A-MSCs) to evaluate the function of exosomal miR-155. BALB/c nude mice were intravenously injected in vivo with GC exosomes with different levels of miR-155 to determine changes in adipodifferentiation of A-MSCs. Results: Exosomes derived from GC cells suppressed adipogenesis in A-MSCs as characterized by decreased lipid droplets. Similarly, A-MSCs co-cultured with GC exosomes exhibited increased ATP production through brown adipose differentiation characterized by highly dense mitochondria and enhanced UCP1 expression (P < 0.05). Mechanistically, exosomal miR-155 secreted from GC cells suppressed adipogenesis and promoted brown adipose differentiation by targeting C/EPBβ, accompanied by downregulated C/EPBα and PPARγ and upregulated UCP1 (P < 0.05). Moreover, overexpression of miR-155 in GC exosomes improved CAC in vivo, which was characterized by fat loss, suppressed expressions of C/EPBβ, C/EPBα, and PPARγ in A-MSCs, and high expression of UCP1 (P < 0.05). Decreasing the level of miR-155 in injected GC exosomes abrogated the improved CAC effects. Conclusions: GC exosomal miR-155 suppressed adipogenesis and enhanced brown adipose differentiation in A-MSCs by targeting C/EPBβ of A-MSCs, which played a crucial role in CAC.
Role of Computer-Aided Systems in Production Flexibility: A Study of the Application of Industry 4.0 Technological Concepts in Manufacturing Industries
Authors: Onyeneke Victor Chiemerem
Published: March 2022

Sustainability is the core concern of every business; The exploration of avenues to maintain sustainability while staying competitive with high level of productivity remains a vital endeavor. Production flexibility is a key area that can enhance the sustainability of manufacturing industries as it can ensure product availability, scalability, agility/fault tolerance as well as disaster recovery potentials. Technological advancements have provided avenues where companies can enhance virtually all aspects of their operations for efficiency, effectiveness, and productivity. This paper uses both quantitative and qualitative research approach to identify the capability requirements for smart and effective production management and subsequent analysis is done using Multi-Criteria Decision-Making methodology to identify and rank various industry 4.0 technologies and concepts that can provide these smart capabilities in in manufacturing industries to aid the businesses to achieve sustainability with production flexibility. The paper identifies over 12 smart capabilities and 9 Industry 4.0 Technologies which are applicable to production management. It also compares results from the analytics of historical I4.0 implementation as discussed in literatures with the current state as deduces from survey feedbacks from various manufacturing industries.
Artificial Intelligence and Online Hate Speech Moderation: A Risky Match?
Authors: Alkiviadou Natalie
Published: March 2022

Artificial Intelligence is increasingly being used by social media platforms to tackle online hate speech. The sheer quantity of content, the speed at which is it developed and the enhanced pressure companies are facing by States to remove hate speech quickly from their platforms have led to a tricky situation. This commentary argues that automated mechanisms, which may have biased datasets and be unable to pick up on the nuances of language, should not be left unattended with hate speech as this can lead to issues of violating freedom of expression and the right to non-discrimination.
Augmenting Azoles with Drug Synergy to Expand The Antifungal Toolbox
Authors: Kane Aidan , Carter Dee A.
Published: March 2022

Fungal infections impact the lives of at least 12 million people every year, killing over 1.5 million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven resistance in many serious fungal pathogens, and there is an urgent need to expand the current antifungal ar-senal. Recent research has focused on improving azoles, our most successful class of antifungals, by looking for synergistic interactions with secondary compounds. Synergists can co-operate with azoles by targeting steps in related pathways, or they may act on mechanisms related to re-sistance like active efflux or on totally disparate pathways or processes. A variety of sources of potential synergists have been explored, including pre-existing antimicrobials, pharmaceuticals approved for other uses, bioactive natural compounds and phytochemicals, and novel synthetic compounds. Synergy can successfully widen the antifungal spectrum, decrease inhibitory dosag-es, reduce toxicity, and prevent the development of resistance. This review highlights the diversity of mechanisms that have been exploited for the purposes of azole synergy and demonstrates that synergy remains a promising approach for meeting the urgent need for novel antifungal strate-gies.
Factors Associated with the Suspected Delayed Language Development of Early Childhood in Southern Thailand
Authors: Kusol Kiatkamjorn , Rithipukdee Namfon
Published: March 2022

Many children have suspected delayed language development and need extensive support from parents and the health care team. This study aimed to investigate suspected delayed language development and factors associated with suspected delayed language development among early childhood in Southern Thailand. Children aged 24 to 60 months were recruited as study samples using stratified random sampling conducted in 23 districts and simple randomized seven sections (425 children). Instruments comprised demographic data of the children and families, The preschool temperament questionnaire, and the Language Development Screening questionnaire using developmental surveillance and promotion manual. I was collecting data from July 2020 to January 2021. Data analysis used descriptive statistics and logistic regression. The results showed that 40.9 percent suspected delayed development. Daily screen time exceeding 2 hours per day (A.O.R. = 17.30, 95% CI: 7.35-40.72), and regarding a child's temperament, moderate-to-difficult temperament (A.O.R. = 9.56, 95% CI: 5.12-17.85) were significantly associated with a suspected delay of language development. The study suggested two-way communication and appropriate responses will help develop children's language.
A Study on the Spinning of Combined Spinneret Holes With Various Cross-Sections
Authors: Li Fei , Feng Pei , Ye He , Yang Chongchang
Published: March 2022

In this paper, a method of direct spinning is proposed for direct spinning of heterogeneous spun wire-blown holes standard parts and the motherboard mounted on the spin board assemblies. The standardization of the spinneret hole was conducive to improving the machining accuracy and efficiency of the pores, and the spinneret holes could be replaced in time when a hole in the spinneret fails. Moreover; on the other hand, according to the needs of the process of spinning, the spinnerets with various cross-sections were combined and installed on the same motherboard for spinning, and the spinning obtained different bionic new functional products. Based on the results, a finite element model of the standard part of the spinneret hole was developed, and the spinnability of the combinable spinnable spinneret board was verified by simulating the melt flow in the spinneret channel through POLYFLOW software. Further, by the processing of the spinneret, the motherboard was installed into a combined spinneret, and the spinneret assembly was installed on the spinning machine for the experiments. Furthermore, the tow section was observed using a microscope, and the results showed the feasibility of the proposed method.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 12.03.2022 г. по 18.03.2022 г.
Authors: Зимирова Анастасия , Поспелов Михаил , Иванова Александра , Дмитриева Людмила , Чумачкова Елена , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир
Published: March 2022

В обзоре представлен анализ эпидемиологической ситуации в странах мира по COVID-19, за неделю с 12.03.2022 г. по 18.03.2022 г.
Numerical Evaluation of a Novel Slot-Drill Enhanced Oil Recovery Technology for Tight Rocks
Authors: Amer Hassan , Olorode Olufemi
Published: March 2022

Enhanced oil recovery (EOR) is essential in shale/tight formations because primary recovery typically produces less than 10% of the original hydrocarbon in place. This work presents a novel “slot-drill” EOR (SDEOR) technology, which involves injecting gas through a horizontal fracture that is cut into the formation near the top of the reservoir (using a tensioned abrasive cable mounted to the drillstring) and producing oil from a second slot-drilled horizontal fracture near the bottom of the reservoir.

A robust 3D projection-based embedded discrete fracture model (pEDFM; EDFM) is used to model the natural fractures in these slot-drilled unconventional oil reservoirs accurately and efficiently. Connectivity and uncertainty analyses are performed to determine the percolation threshold, where natural fractures influence hydrocarbon production appreciably. The results of this work indicate that the proposed technology can yield over a threefold increase in oil recovery relative to the cyclic gas EOR (CGEOR) method. This simulated recovery is high regardless of the presence of natural fractures or the type of gas/solvent injected (such as CH4, N2, CO2, and flue gas). The simulation results also indicate that the continuous gas injection, higher relative oil permeability, and the role of gravity-drainage are the main reasons why the oil recovery from the SDEOR is three times that from the CGEOR method.

In conclusion, this is the first presentation and numerical simulation study of applying pairs of parallel slot-drilled fractures to enhance the recovery from challenging unconventional reservoirs (such as the Bakken shale) that have not been successfully enhanced using the CGEOR method. The dramatic increase in recovery from SDEOR, coupled with its applicability regardless of the stress state or formation brittleness, could change how unconventional reservoirs are completed and produced in the future.
BNT162b2 mRNA Vaccinations in Israel: Understanding The Impact and Improving The Vaccination Policies by Redefining The Immunized Population
Authors: Ross Chana , Spector Oren , Tsadok Meytal Avgil , Weiss Yossi , Barnea Royi
Published: March 2022

Background
By the end of February 2021, when 48% of the Israeli population was immune, the number of new positive COVID-19 cases significantly dropped across all ages. Understanding which parameters influenced this drop and how to minimize the number of hospitalizations and overall positive cases is urgently needed.
Methods
In this study we conducted an observational analysis which included COVID-19 data with over 12,000,000 PCR tests from 250 cities in Israel. In addition, we performed a simulation of different vaccination campaigns to find the optimal policy.
Results
Our analysis revealed that cities with younger populations reached a decrease in new cases when a lower percentage of their residents were immunized, showing that median age is a crucial parameter effecting overall immunity, while other parameters appeared to be insignificant. This variance between cities is explained by recalculating the immunized population and multiplying each individual by a factor symbolizing the impact of their age on the spread on the virus. This factor is easily calculated from historical data of positive cases per age.
Conclusions
The simulation proves that prioritizing different age groups or changing the rate of vaccinations drastically effects the overall hospitalizations and positive cases.
Intelligent IoT Security Monitoring based on Fuzzy Optimum-Path Forest Classifier
Authors: Xu Yongzhao , Souza Renato , Medeiros Elias , Jain Neha , Zhang Lijuan , Passos Leandro , de Albuquerque Victor Hugo C.
Published: March 2022

The detection of intrusions in IoT networks is essen- tial to maintain the availability and integrity of data transmitted and generated by devices connected to these networks. This is primarily when the data originates from critical activities, such as activities in the military, financial, industrial, and health sectors. Machine learning techniques have been adopted to create ways to detect or improve the accuracy of existing models for automatic intrusion detection. However, it is difficult to find in the literature an accurate intrusion detection technique in an IoT environment, as there are different types of attacks that can happen in different ways. Therefore, to solve this problem, this work proposes applying Fuzzy OPF (Optimum-Path Forest) as a new detection algorithm for any threat that escapes the regular traffic of an IoT network. We evaluate our proposed approach by using five different ML algorithms: Linear Discriminant Analysis, Support Vector Machine, Bayes, K-Nearest Neighbors, and Optimum-Path Forest. Experimental results analysis showed that our proposed model outperforms well-known algorithms in the literature regarding the Accuracy, Recall, and F1 metrics.
Inflammatory potential of gut microbiota from monozygotic twin pair discordant for ulcerative colitis
Authors: Knudsen Lina Almind , Zachariassen Line Sidsel Fisker , Strube Mikael Lenz , Havelund Jesper Foged , Pilecki Bartosz , Nexoe Anders Bathum , Møller Frederik Trier , Sørensen Signe Bek , Marcussen Niels , Færgeman Nils Joakim , Franke Andre , Bang Corinna , Holmskov Uffe , Hansen Axel Kornerup , Andersen Vibeke
Published: March 2022

Gut microbiota perturbations are common in inflammatory bowel disease (IBD), including ulcerative colitis (UC), but it is unclear whether this is a result of the disease or a contributing factor. In twin pairs discordant for IBD, the healthy co-twin is at an increased risk of IBD and has a gut microbiota more similar to IBD patients than healthy individuals. Moreover, appropriate medical treatment may reduce the perturbations. To investigate the association of the microbiota and IBD, we transferred stool from a discordant twin pair, i.e. one healthy and one treated for UC, to germ-free mice by the inoculation of pregnant dams. Dextran sodium sulfate was used to induce colitis in the pups. Offspring of mice inoculated with stool from the UC twin had a lower disease activity index (DAI) and gut inflammation and microbiota with higher alpha diversity and a more anti-inflammatory profile, with the exclusive presence of the anti-inflammatory Akkermansia species, compared to offspring of mice inoculated with stool from the healthy co-twin. These results indicate that the healthy twin had a more inflammatory microbiota than the twin treated for UC. Our study suggests that individuals genetically susceptible to IBD have a more inflammatory gut microbiota. Future studies should assess the potential use of individual gut microbiota inflammatory profiles in personalised medicine.
Effect Of Wifi Signal Exposure In Utero And Early Life On Neurodevelopment And Behaviors Of Rats
Authors: Wu Hongmei , Min Dongyu , Sun Buxun , Ma Yifan , Chen Hongpeng , Wu Jing , Ren Ping , Wu Jiabi , Cao Yonggang , Zhao Baoshan , Wang Peng
Published: March 2022

Objectives: To examine the long-term effects of prenatal and early life WIFI signal exposure on neurodevelopment and behaviors as well as biochemical alterations of Wista rats. Methods: On the first day of pregnancy (E0), expectant rats were allocated into two groups: the control group (n=12) and the WiFi-exposed group (WiFi group, n=12). WiFi group was exposed to turn on WiFi for 24h/day from E0 to postnatal day (PND) 42. The control group was exposed to turn off WiFi at the same time. On PND7-42, we evaluated the development and behavior of the offspring, including body weight, pain threshold, and swimming ability, spatial learning and memory among others. Also, levels of proteins involved in apoptosis were analyzed histologically in the hippocampus in response to oxidative stress. Results: The results showed that WiFi signal exposure in utero and early life (1) increased the body weight of WiFi+M group, (2) no change in neuro-behavioral development were observed in WiFi group, (3) increased learning and memory function in WiFi+M group, (4) enhanced comparative levels of BDNF and p-CREB proteins in the hippocampus of WiFi+M group. Signiﬁcance: Prenatal WiFi exposure has no effects on hippocampal CA1 neurons, oxidative equilibrium in brain and neurodevelopment of rats. Some effects of prenatal WiFi exposure are sex-dependent. Prenatal WiFi exposure increased the body weight, improved the spatial memory and learning function and induced behavioral hyperactivity of male rats.
Prevalence and Spatial Distribution of “Optimal Birth” Outcomes in the US, 2018-2019
Authors: Dyer Lauren , Bell Caryn , Perez Susan , Crear-Perry Joia , Theall Katherine , Wallace Maeve
Published: March 2022

Background
A shift in focus towards healthy reproductive outcomes may reveal opportunities for novel interventions and strategies to promote optimal health.
Methods
Using variables from the National Center for Health Statistics Period Linked Birth/Infant Death File, we calculated Empirical Bayes smoothed (EBS) rates of optimal birth for the total population and by maternal race/ethnicity by applying the smoothing tool in GeoDa version 1.18.0.10 We defined counties achieving greater racial birth equity as those where the total population EBS optimal birth rate was higher than the national 75th percentile and the absolute difference between maternal racial/ethnic categories was smaller than the national 25th percentile difference.
Results
During the 2018–2019 period, 49.80% of overall births could be classified as an “optimal birth” according to the study definition. Of the 3140 US counties, only 282 (8.98%) appeared to advance White-Black equity in optimal births, and 205 (6.53%) appeared to advance White-Hispanic equity in optimal births.
Conclusions
In the effort improve maternal health, we should focus not only on the absence of negative outcomes, but also the occurrence of positive outcomes. Our analytic results suggest that optimal births can be measured and that spatial patterns exist at the county level.
Effectiveness of Mobile Reticulum Hyaluronic Acid in the Treatment of Meniscal Tears and/or Cartilage Lesions in Knee Due to Arthritis
Authors: Balius Ramon , Guillermo Álvarez Rey , Fernando Baró Pazos , Miguel Domínguez Melendez , Enrique Gastaldi Orquín , Alberto Gómez Martin , Luisa Ibáñez Martín , Francisco Lara Pulido , Antonio Leal Graciani , Antonio León Garrigosa , Luis Martín Leis José , Manuel Morales Santias , Luis Pérez Carro , Orlando Pompei Fernandez , Jordi Puigdellívol Grifell , César Quesada de la Gala , Antonio Rodas Pereira José , Andrés Valentí Azcarate
Published: March 2022

Objective
To evaluate the clinical effectiveness, tolerability, and impact on quality of life of Hymovis in the conservative treatment of overuse cartilage lesions due to osteoarthritis and/or meniscus tears.
Patients and methods:
Non-interventional, prospective, descriptive, observational, multicenter study of 165 patients aged over 18 years with osteoarthritis and/or a meniscus tear treated with two injections of Hymovis. Follow-up visits were held at 10 days and at 1, 2, and 3 months for all patients and at 6 months for patients with osteoarthritis with or without a meniscus tear. Clinical and functional parameters were collected at each participating clinic and patients also completed the Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC).
Results
Patients in all three groups (osteoarthritis, meniscus tear, and osteoarthritis plus meniscus tear) reported a marked and significant reduction in pain after treatment with Hymovis. At 6 months, patients with osteoarthritis and combined lesions showed improvements of the signs and symptoms associated with the pathology. Patients with only OA showed also improvement in palpation, mobility, and joint movement parameters. Patients in the meniscus tear group showed improvements in physical examination, clinical manoeuvre, and joint movement parameters. Additional improvements were observed for quality of life, activities of daily living, and sport and recreation. Satisfaction with treatment was very high, with 85% of osteoarthritis patients reporting considerable or very considerable improvement. None of the patients reported any severe adverse effects.
Conclusions
Hymovis is a safe and effective option for the conservative treatment of overuse cartilage lesions in the knee due to osteoarthritis and/or meniscus tears.
Study on the Response of Hydrothermal Environment at Different Elevations (Near the Surface) to the Water Condition of Underlying Surface
Authors: CHAO* Jinlong* , ZHAO Deyi , LI Haojie , YANG Shuo , WU Lindong , ZHANG donghui
Published: March 2022

In recent years, many ecological problems brought by rapid urbanization have attracted attention, but less attention has been paid to the daily variation of hydrothermal environment at small scale. In order to precisely investigate the effect of subsurface moisture conditions on the daily variation of the near-surface air-hydrothermal environment, this study was conducted from May 21 to May 24, 2019, in a quantitative water control simulation experiment in the bare ground of the University City, Yuci District, Jinzhong City, China, to compare the diurnal air-hydrothermal environment at different height (0.3 m, 1.0 m, and 1.5 m) of different ground surfaces by differential watering (0 L, 30 L, and 60 L) Variation. The results show that: 1) Under the control of other variables, the cooling effect was more obvious with the increase of irrigation amount. The average cooling effect of 30L was 0.47℃ while 60L was 0.61℃. 2) At different heights near the ground (0.3 m, 1.0 m and 1.5 m), the cooling effect was most obvious at height of 0.3m. And the temperature decreased 0.636℃, 0.400℃, 0.373℃at the three height under 30L irrigation; 0.991℃, 0.605℃, 0.226℃ under 60L irrigation. 3) The cooling effect at is more significant at daytime (0.72℃) than night (0.27℃). 4) The difference was smaller in the initial stage of irrigation, larger in the middle stage of irrigation, and smaller in the later stage of irrigation. The variation of relative humidity of air at different height near the surface is influenced by three factors: diurnal temperature variation, irrigation amount and vertical air movement day and night. Quantitative observation and research on water and heat environment can not only improve the discussion on the heat conduction mechanism of near-surface water, but also have important practical significance to the improvement of the underwater thermal environment of city.
The Correlation Between Atmospheric Conditions and Clinical Dry Eye
Authors: Li Juan , Zhang Li-Juan , Liang Rong-Bin , Xu San-Hua , Pan Yi-Cong , Li Qiu-Yu , Shu Hui-Ye , Kang Min , Yin Pin , Shao Yi
Published: March 2022

Objective: To explore the correlation between dry eye and levels of the atmospheric pollutants ozone (O3) and nitric dioxide (NO2), and its application in the prediction, prevention and personalized medical treatment of dry eye.Methods: Clinical data of 75,279 patients with dry eye were selected and categorized according to age, gender, and season. We analyzed the concentrations of O3 and NO2 and used Pearson correlation analysis to study the effect of both pollutants on the outpatient rate of dry eye.Results: The concentrations of O3 and NO2 changed periodically over time. The number of outpatient visits for dry eye were significantly correlated with O3 and NO2 levels. The environmental concentration of NO2 was significantly related to dry eye in patients of all ages, and O3 levels were related to dry eye in patients younger than 60 years old. There was no significant relationship with gender There were significantly more dry eye clinic visits in the summer compared to other seasons.Conclusion: Ambient air pollution and weather changes may increase the incidence of dry eye. Air pollution may have a predictive effect on the occurrence of dry eye, and based on this, we can prevent and personalized treat the occurrence and aggravation of dry eye.