bluuebunny/crossref_metadata_2025 huggingface dataset:
Cognitive Interventions to Improve a Specific Cognitive Impairment for Adults With TBI (June 2013–October 2020)
Authors: Radomski Mary Vining , Giles Gordon Muir , Carroll Ginger , Anheluk Mattie , Yunek Joe
Published: September 2022

Systematic Review Briefs provide a summary of the findings from systematic reviews developed in conjunction with the American Occupational Therapy Association’s Evidence-Based Practice Program. Each Systematic Review Brief summarizes the evidence on a theme related to a systematic review topic. This Systematic Review Brief presents findings from the systematic review on cognitive interventions to improve a specific cognitive impairment for adults with TBI.
Physical Activity Interventions That Address Motor and Balance Impairments and Skills for Adults With Traumatic Brain Injury (TBI) (2012–2021)
Authors: Fields Beth , Li Kitsum , Kinney Adam , Condon Olivia , Villavicencio Emilio
Published: September 2022

Systematic Review Briefs provide a summary of the findings from systematic reviews developed in conjunction with the American Occupational Therapy Association’s Evidence-Based Practice Program. Each Systematic Review Brief summarizes the evidence on a theme related to a systematic review topic. The systematic review is on interventions to address motor and balance impairments to improve occupational performance for adults with traumatic brain injury.
Virtual Interventions That Address Motor and Balance Impairments and Skills for Adults With Traumatic Brain Injury (TBI) (2012–2021)
Authors: Li Kitsum , Fields Beth , Kinney Adam , Condon Olivia , Villavicencio Emilio
Published: September 2022

Systematic Review Briefs provide a summary of the findings from systematic reviews developed in conjunction with the American Occupational Therapy Association’s Evidence-Based Practice Program. Each Systematic Review Brief summarizes the evidence on a theme related to a systematic review topic. This Systematic Review Brief presents findings from the theme of virtual interventions that address motor and balance impairments and skills for adults with traumatic brain injury.
Survey on the Small Mammals in Sg. Kangkawat Research Station Imbak Canyon Conservation Areas
Authors: Bansa Lawrence Alan , Rosli Qhairil Shyamri , Daud Ummu Safiyyah , Amat Amirrah , Morni Muhd Amsyari , William Dee Julius , Jinggong Emy Ritta , Rajasegaran Praveena , Senawi Juliana , Kumaran Jayaraj Vijaya , Azhar Isham , Mahyudin Azniza , Hasan Noor Haliza , Anwarali Khan Faisal Ali
Published: September 2022

Sg. Kangkawat Research Station is a newly established research station in the Imbak Canyon Conservation Area, Sabah which encompasses both primary and secondary forest areas. Limited data is  available on the small mammal diversity for this particular area. Therefore, a survey-based study on small mammal diversity was carried out between the 29th September – 8th October 2018 along the established trails within the vicinity areas of this research station. Small mammal trapping was done using traps (mist nets, harp traps, cage traps and pitfall traps) employed randomly along the Nepenthes trail, the Kawang trail, the South Rim trail and the Pelajau trail. This study documented a total of 32 small mammal species i.e. represented by 26 species (15 spp. of new records for ICCA ) of volant small mammals (Chiroptera) and 6 species of non-volant small mammals (Rodentia, Scadentia, Insectivora, Carnivora). The total number of specimens recorded was 108. A new distribution record on the Free-tailed Bat, Chaerephon cf. johorensis, was documented for Sabah and Borneo during this study.
Effect of Different Solvent Extractions on Total Phenols, Tannins, and Flavonoids Content of Indigenous Medicinal Plant Blumea arnakidophora Mattf. from Sabah.
Authors: Ng Shean-Yeaw , Zulkifli Zulzariani Isma , Abu Bakar Mohd Fadzelly , Suleiman Monica
Published: September 2022

This research represents the first study on the effect of different solvent extractions on the total phenols, tannins, and flavonoids content of indigenous medicinal plant Blumea arnakidophora from Sabah. A total of three solvent types were used in this study: 80% methanol, hot water and distilled water. Determination of phytochemical contents mentioned above was determined using Folin-Ciocalteu Reagent (FRC) method and Aluminium Chloride Colorimetry (ACC) method. The highest total phenols content (71.7 ± 7.0 mg GAE/g) and flavonoids content (33.7 ± 0.6 mg CE/g) were obtained from the 80% methanol extract from the leaves, whereas the highest tannin content (4.9 ± 0.7 mg GAE/g) was obtained from hot water extract from the leaves. From the statistical analyses, the phenols content extracted from the leaves with distilled water showed significant difference (p < 0.05) with hot water and 80% methanol extracts. The tannin content and flavonoid content extracted from the stems and leaves did not show any significant difference (p > 0.05) among the extraction solvent used. This work provides a preliminary result on selecting an effective extraction solvent for phytochemicals investigation on B. arnakidophora.
Inventory of Marine Fauna on Reef Balls Structures of Selingan Island, Sandakan, Sabah, Malaysia
Authors: Saleh Ejria , Kiat Yap Tzuen , Geng Chen Nuo , Masidi Adam Malik , Joseph Juanita
Published: September 2022

Selingan Island is well known as a turtle sanctuary in Sandakan, Sabah. However, beach erosion has affected both infrastructure and turtle nesting grounds on the island. As one of the solutions, stone revetment and reef ball structures were deployed at the southeast part of the island in 2005 and 2007, respectively. The uneven stony surface of reef ball structures creates tiny pockets of space for attachment and colonization of coral larvae and sessile invertebrates. The objectives of this study are to determine the condition of the reef ball structures and to identify the types of marine fauna within these structures. The field surveys were carried out in May and December 2017. The survey area covered the 120 m length of balls structures for inventory of marine fauna using random quadrat sampling and observation of the reef balls condition. The survey areas were divided into Part 1 (1- 40 m), Part II (40-80 m) and Part III (80-120 m) from the shoreline of the island.  There was only one reef ball unit damaged and others were intact with encrusting marine invertebrates and other associated marine life. The structures of the reef balls play an important role as an artificial marine habitat.  A total of 3,583 individual (298 inv/m-2) of invertebrates (barnacles, bivalves, limpets and gastropods) were identified and 26 marine fauna species comprising of fishes, algae and corals associated with the reef balls structures. The marine fauna was expected to be higher if the survey could be done at the different tidal cycles, weather conditions and increase number of the survey. The findings provide insight of marine fauna at the reef balls structure in Selingan Island and enhance baseline data for marine resources management in the marine protected area of Turtle Island Parks.
A Preliminary Survey on Edibles and Medicinal Plants Used By Dusun of Kampung Pinolobu, Kadamaian, Kota Belud, Sabah, Malaysia
Authors: Awang-Kanak Fadzilah , Matawali Azlinah , Jumat Nur Ramziahrazanah , Bakri Sitty Nur Syafa
Published: September 2022

This paper provides a brief enumeration of 22 species of plants and four species of fungi as wild edibles, and 13 species of plants that have been used for medicinal purposes by Dusun people of Kampung Pinolobu, Kadamaian, Kota Belud, Sabah. Seven informants were selected using snowball sampling technique, and data on edibles and medicinal plants were collected using semi structured interviews. This study reveals how Dusun people of Kampung Pinolobu used 13 species of medicinal plants to treat ailments and diseases like fever, high blood pressure, flatulence, rheumatism, cold, cough, and gastric pain. The flower of Carica papaya and fruit of Passiflora foetida are used for high blood pressure treatment, leaves of Manihot esculenta serve two purposes, as traditional vegetables and also consumed to avoid flatulence. Decoction made from the root of Ficus septica was given to women during postpartum recovery as they believed that it would help to keep the body warm, treat headache, and stomach pain. Paste made from leaves of Melastoma malabathricum is used to treat wounds. Meanwhile crushed leaves of Hibiscus rosa-sinensis, root decoction of Imperata cylindrica, sap from Calamus sp. are used to treat high fever, crushed leaves of Hibiscus rosa-sinensis is also used to subside carbuncle.  Decoction of young leaves of Psidium gujava and Leucosyke capitella are used to treat stomach pain. Meanwhile decoction of crushed tuber of Curcuma longa is used to treat gastric pain.
Silvered Langur (Trachypithecus cristatus) Survey in Sibuti Wildlife Sanctuary, Miri, Sarawak
Authors: Wan-Azman Wan Nur Syafinaz , Mazlan Norfarhana , Abd Wahab Muhammad Farhan , Taib Abdul Ajis , Mali Sunni , Anwarali Khan Faisal Ali
Published: September 2022

A rapid and passive primate survey using a scanning technique was conducted in Sibuti Wildlife Sanctuary (Sibuti WS) from 11th to 16th July, 2018. This study provided the first confirmed record of the presence and the diet of silvered langur in the wildlife sanctuary. A group of silvered langur that comprise 20 to 30 individuals were observed in the vicinity of the sanctuary. The diurnal langur feeds on fig plants (Ficus sp.), simpoh air (Dillenia suffruticosa) and tree from the family Leguminosae. However, this langur population appears to be isolated and is probably decreasing due to limited food sources, intra- and interspecific competition, and  hunting pressure by local people.
Secondary Metabolites of the Soft Coral Lobophytum pauciflorum
Authors: Arunasalam Mirushan , Yuanwei Liu , Tan Yee-Yein , Ramachandram Tulasiramanan , Palaniveloo Kishneth , Nagappan Thilahgavani
Published: September 2022

Secondary metabolites, derivatives of primary metabolites, are known for their biological activities. Marine organisms, especially marine invertebrates such as sponges, tunicates, soft corals, bryozoans, and nudibranchs are important source of secondary metabolites with diverse biological properties. Approximately 40,000 marine natural products have been identified from various marine resources. Soft corals are a group of invertebrates known for their production of a vast range of metabolites with great structural diversity. Among 39 genera of soft coral Alcyonacean, a total of eighteen different species of Lobophytum soft corals have been identified. Isolation of secondary metabolites from the genus Lobophytum is tremendously explored by researchers worldwide. This review compiles several secondary metabolites that have been isolated and published on the soft coral L. pauciflorum, including the compound structures and some notable bioactivity.
Change management leadership and its impact on employees’ resistance to change : case study of selected automobile companies in the Durban Metropolitan Region of KwaZulu-Natal (South Africa)
Authors:   , Chukwuma Nonye Emmanuella
Published: September 2022

This study is based on the contention that the world is shifting from an industrial paradigm to a post-industrial paradigm and, as a result, change ought to be managed effectively. The literature reviewed for this study has indicated that there are neither appropriate models to address monumental changes in the automobile industry, nor tools to address resistance to change, due to inadequate leadership skills. Accordingly, the study investigates existing change leadership styles and particularly focuses on the transformational and transactional change leadership styles which also include other leadership styles. The study further explores factors that influence resistance to change: demographic factors; the theoretical components of resistance to change; and communication adequacy. The research study also explores the process of a change management leadership model adapted from related research studies, which is aligned with managing resistance effectively at the selected automobile dealership companies in the Durban Metropolitan Region of KwaZulu-Natal. A sample size of 300 staff members and managers were conveniently considered, comprising 270 staff and 30 managers, in a mixed-method research study. However, only 170 questionnaires were returned, and 28 managers were successfully interviewed, which resulted in an average response rate of 66% (63% for the quantitative study and 93% for the qualitative study). To analyse the data quantitatively, inferential statistics and descriptive statistics were used. The hypothesised model formulated was tested with the structural equation model (SEM). Findings revealed no relationship between transformational leadership and resistance to change. However, there was a relationship between transactional leadership and resistance to change. Qualitative data were analysed using thematic analysis employing the NVIVO software package. Recommendations from the study include the application of the proposed change management leadership model and other intervention strategies mentioned in the study for the improvement of change management in the dealership companies.
Unlocking the potential of religious tourism in Zimbabwe : a case for Harare city
Authors:   , Valentine Tanyaradzwa Ziyenge
Published: September 2022

Religious tourism has, over the years, witnessed considerable growth due to its contribution to mainstream tourism and the economy. Consequently, several countries have increasingly continued to regard it as vital to their economies. However, some developing countries such as Zimbabwe have not yet fully incorporated religious tourism into their economies. Therefore, this study sought to explore religious tourism as a potential driver for socio-economic development in Harare. The objectives of the study were to identify the major religious tourism activities taking place in Harare, determine their socio-economic benefits, challenges hindering the development of religious tourism, and offer possible strategies that can be adopted to promote the growth of religious tourism in the City of Harare. A mixed-method data collection approach, which included the use of questionnaires and interviews, were used to gather data. A sample of 100 randomly selected respondents was chosen to participate in the study. Semi-structured interviews were also conducted using a sample comprised of pilgrims, church leaders, Zimbabwe Tourism Authority management, and the City of Harare Municipal Authority. The study found that conventions and Christian-based camps are the most prevalent religious tourism activities in Harare attracting the highest number of religious tourists compared to other religious activities in the city of Harare. Furthermore, the study revealed that the growth of religious tourism has led to several social and economic benefits. The social benefits attributable to religious tourism include improved quality of life, social cohesion, enhanced cultural education and conservation, and improved faith among congregants. The economic benefits related to religious tourism include increased job opportunities, increased municipal tax revenue, and improved public utility infrastructure. Nonetheless, the development of religious tourism in Harare has been hampered by factors such as inadequate accommodation facilities, inferior quality of existing restaurants, lack of government support, environmental pollution, safety and security issues, and poor infrastructural development. Therefore, it was recommended that the regulatory board, the Zimbabwe Tourism Authority, leads the promotion of religious tourism. Tourism stakeholders should collectively strategize to unlock and harness the potential of religious tourism in the country. Additionally, the study recommended that church authorities offer tourist facilities, such as adequate and standard guest houses, restaurants, cafeterias, lodges, and bathing rooms. Similarly, church leadership should ensure that the safety and security of congregants are improved during their stay. Standard litter management practices should be adopted to address the environmental pollution problem. Future studies must be extended to other religious sects and other regions of Zimbabwe. In equal measure, various methodologies should be adopted to probe the problem further.
XVII. Yüzyılda Bursa Nakîbü’l-Eşrâf Kâim-i Makâmı Seyyid Cafer Paşa ve Ailesi
Authors: MAYDAER Saadet
Published: September 2022

Nakîbü’l-eşrâflık kurumu seyyidlerin soylarının düzenli takibi ve seçkin konumlarının getirdiği bazı uygulamaların yerine getirilebilmesi için tesis edilmiştir. Merkezdeki nakîbü’l-eşrâfların yerel temsilcileri konumundaki nakîbü’l-eşrâf kâim-i makâmların yaşadıkları bölgedeki saygın ve seçkin seyyid ailelerden seçildiği bilinmektedir. Bursa’da ilk dönemlerde görev yapan nakîbü’l-eşrâf kâim-i makâmlar arasında hakkında en çok bilgi sahibi olabildiğimiz kişi, Seyyid Cafer Paşa’dır. Cafer Paşa Bursa’da kökleri Tebriz’e dayanan itibarlı bir seyyid ailesine mensuptur. Edindikleri bu itibarlı konumlarının bir sonucu olarak dedeleri Emir Gazi’den itibaren aile üyeleri selâtîn vakıfları mütevelliliği ve düzene konulmasını sağlama gibi önemli görevlere getirilmişlerdir. Cafer Paşa’nın vefatının ardından oğlu Seyyid Mehmed nakîbü’l-eşrâf kâim-i makâmı olarak atanmış, ilerleyen yıllarda ise torunu İbrahim aynı vazifeyi sürdürmüştür. Böylece ailenin bilindiği kadarıyla üç ferdi Bursa nakîbü’l-eşrâf kâim-i makâmı olarak görev yapmıştır.

Bu çalışma, yaşadıkları çevrede tanınmakla birlikte çok da ünlü olmayan, dolayısıyla haklarında daha sınırlı bilgiler bulunan seyyid bir ailenin tarihini şer‘iyye sicilleri ve arşiv belgelerindeki sınırlı bilgilerin peşine düşerek araştırmaktadır. Bu şekilde Cafer Paşa’nın kendinden önceki beş atasının ismi belirlenebilmişken, kendisinden sonra gelen sekiz nesil evlat ve torunlarına dair doğumlarından, evliliklerine, mülk-alım satımlarından, miras anlaşmazlıklarına ve vakıflarla ilişkilerine kadar hayatın çok farklı alanlarına dair bilgiler elde edilebilmiştir. Böylece 17. yüzyılda Bursa’da saygın, ama şöhretli olmayan bir seyyid ailesinin toplumsal konumu, sosyal, ekonomik ve hukukî ilişkileri ortaya konulmaya çalışılmıştır.
SIGNIFICANCE OF BIOLOGICAL, BEHAVIOUR, SOCIAL AND LIVING CONDITIONS FACTORS IN FORMING THE SYSTEM «PARASITE - HOST» (ENTEROBIUS VERMICULARIS - HOMO SAPIENS), CHARACTERIZED Y DIFFERENT INVASION INTENSITY
Authors: Butenkova E. M.
Published: September 2022

Quantity valuation of biological, behaviour, social and living conditions factors in forming the system parasite - host (Enterobius vermicularis - Homo sapiens) has been carried out. Prognosis coefficients and information value of the most significant factors of enterobius invasion development that is typical of children in Gomel region and is characterized by low, medium and high invasion intensity have been given. Risk groups of development high intensity enterobius invasion have been distinguished on the basis of the received data and directions of the increase in effectiveness of the enterobius causative agent control have been suggested.
EFFECT OF AMINO ACIDS COMPOSITIONS ON THE LEVEL OF FREE AMINO ACIDS OF THE LIVER UNDER CHRONIC ALCOHOL INTOXICATION
Authors: Razvodovsky Y. E. , Smirnov V. Y. , Doroshenko E. M.
Published: September 2022

In present study we investigated effect of amino acids composition of BCAA, taurine and BCAA, taurine and tryptophan on the liver amino acids pool of rats under chronic alcohol intoxication. Chronic ethanol intoxication led to increase levels of glutamate, asparagines, glycine, b-alanine, thirozine, and decrease level of alanine in the liver of rats. Administration of composition of BCAA, taurine and tryptophan was found to normalize the levels of aromatic amino acids, glutamate and alanine.
THE MORTALITY FROM CIRCULATORY DISEASES AMONG THE ABLE-BODIED POPULATION OF GOMEL REGION IN 2004-2008
Authors: Lopatina A. L.
Published: September 2022

For the purpose of defining ways to reduce mortality among the able-bodied population there was done a survey of the mortality from circulatory diseases among people of this group in Gomel region throughout 2004-2008. Circulatory diseases rank second in the able-bodied population death-rate slightly yielding to external factors.
HCV-INFECTION IN GOMEL REGION: CURRENT EPIDEMIOLOGICAL CHRACTERISTIC
Authors: Mitsura V. M. , Volchenko A. N. , Salazhkova I. F. , Starodubtseva M. N.
Published: September 2022

Various forms of HCV-infection in population of the Gomel region has been analyzed, major risk factors of infection and terms of disease revealing are characterized, the mathematical model of determination of time since the moment of infection is developed in the article. Since 1999 the epidemic tendency of HCV-infection (all forms) revealing in the Gomel region has been considered to be stable with the incidence rate of 55,7 per 100 000 population. However, the incident rate of chronic hepatitis C in both the Gomel region and Republic of Belarus as a whole (19,2 and 19,3 per 100 000 population correspondently) exceeds the rate observed in the countries of the European region (6,9 per 100 000) and has tendency to increase. During the first year after infection 18 % infected HCV people are revealed and the detection of 50% infected people occurs during the first 5 years after infection.
THE EXPERIMENT OF WORKING UP A NOISE MAP OF GOMEL
Authors: Bortnovsky V. N. , Zinovich V. N. , Dubinin S. E. , Grachiova V. M.
Published: September 2022

In the article are presented the materials of study of acoustic environment in Gomel, on the basis of which a noise map has been worked up, has been carried out dividing of the city territory in zones depending on the level of acoustic load. The recommendations to decrease living noise by means of architectural-planning and building-acoustic methods have also been given.
EFFICACY OF THE APPLICATION THE HBO IN THE FIRST TIM OF ST SEGMENT ELEVATION MYOCARDIAL INFARCTION: PRELIMINARY RESULT
Authors: Lopatina A. L. , Salivonchik D. P. , Kravchenko L. V.
Published: September 2022

The application of the HBO in the «little» regimes and thrombolytic therapy in the first time of the ST segment-elevation myocardial infarction allow reliably decrease in-patients mortality, p = 0,044.
SURGICAL TACTICS IN TREATMENT FOR ACUTE DESTRUCTIVE PANCREATITIS (literature review)
Authors: Oslavsky A. I.
Published: September 2022

The present article presents literature data on the treatment of acute destructive pancreatitis and its complications in different terms of the disease development.
«ATHLETIC HEART»
Authors: Skuratova N. A.
Published: September 2022

In the article the basic concepts of sports medicine and the features of the electrocardiogram occurring the athletic training are determined. The basic differential concepts of «athletic heart» and principles of inspections of potential sportsmen are presented. The development of the athlete's heart is a fascinating phenomenon produced by physiologic adaptations to the increased demands of exercise. Athletic training can cause morphological cardiac changes as part of physiological adaptation. The problem of «athletic heart» at children who are actively going in for sports and the complexity in the definition of physiological parameters at young athletes and necessity of perfection of the medical control over young sportsmen.
DIABETES MELLITUS AND DEPRESSION DISORDERS (literature review)
Authors: Navmenova Ya. L. , Shylova N. P. , Sevasteeva I. G. , Mokhort T. V.
Published: September 2022

In the article there is a review of the publications dedicated to the prevalence of in depression states diabetes mellitus and to the methods of their assessment. It has shown that the prevalence of depression states in diabetes mellitus exceeds population indices and makes up in general 26,3 %.
ANALYSIS OF THE STRUCTURE OF INITIALLY-PLURAL MALIGNANT NEOPLASMS IN STOMACH CANCER IN VITEBSK AND GOMEL REGIONS OF BELARUS
Authors: Krylov A. Yu.
Published: September 2022

The structure study of initially-plural malignant neoplasm incidence was performed, one of which was the stomach cancer. The performed study has shown that incidence structure of initially-plural malignant neoplasms in Gomel and Vitebsk regions on the whole was approximately the same. Most often the stomach cancer was combined with malignant neoplasms of skin, colon, lungs, mammary gland. Differences in combinations of malignant neoplasms of separate localizations most possibly reflect age-gender peculiarities in the studied regions.
PITUITARY ADENOMAS: HISTORY, SPREAD, CLINICS, DIAGNOSTICS, TREATMENT
Authors: Syty V. P. , Gonchar A. A. , Syty Yu. V.
Published: September 2022

In article there are data about history, spread, clinics, diagnostics and treatment of various types of pituitary adenomas. Modern classifications of pituitary adenomas, МРI semiotics of adenomas and complications (pituitary apoplexy) have been given
ASSESSMENT OF THE EFFECTIVENESS OF PROPHYLACTIC MEASURES TO LIQUIDATE THE IODINE DEFICIENCY AMONG THE POPULATION OF GOMEL
Authors: Bortnovsky V. N. , Zinovich V. N. , Sychkov D. A.
Published: September 2022

In the article the assessment of the effectiveness of the use of domestic iodine salt as a prophylactic means against the development of iodine deficiency pathology among the population of Gomel has been given. The reliable data about the absence of correlative connection between the endemic goiter morbidity and the use of iodine salt have been obtained, which allows to make up a conclusion that the development of iodine deficiency pathology among the population in the present-day ecological regional conditions depends on many factors.
THE ACUTE CORONARY SYNDROME: POSSIBILITY UP-TO-DATE THERAPY (literature review. Part III)
Authors: Salivonchik D. P.
Published: September 2022

The information about the modern medical treatment of the acute coronary syndrome was presented in the this review.
APPLICATION OF THE PREPARATIONS «MEXIDOLUM» AND «PHOSPHOCREATINE» IN THE COMPLEX INTENSIVE THERAPY OF THE INJURED WITH SEVERE MULTITRAUMA
Authors: Batiuk V. I.
Published: September 2022

In the article there are results of the observation and therapy of the injured with severe multitrauma who underwent treatment in the Gomel Regional Clinical Hospital of Emergency Care. The efficiency of the application of antioxidant «Mexidolum» and high-energy preparation «Phosphocreatine» in the complex intensive therapy of traumatic shock of different severity has been proved.
EFFICIENCY OF VARIOUS SCHEMES OF INTERFERON THERAPY IN PATIENTS WITH CHRONIC HEPATITIS С
Authors: Krasavtsev E. L. , Mitsura V. M. , Demchilo A. P.
Published: September 2022

Comparison of different schemes of interferon therapy efficiency is studied in patients with chronic hepatitis C with various viral genotypes. On treatment of chronic hepatitis C it is necessary to be guided not only on clinical, but also pharmaco-economic efficiency of therapy. By means of «cost-effectiveness» analysis it is established that the best price/quality ratio has the scheme with use of interferon monotherapy with high-doses beginning.
EFFECT OF DIFFERENT CONCENTRATIONS OF UREA AND PH ON THE FLUORESCENCE PARAMETERS OF BOVINE SERUM ALBUMIN
Authors: Avdeev P. A. , Ignatenko V. A. , Kornoushenko Yu. V. , Evtuhova L. A.
Published: September 2022

Urea is a chemical effect on the conformation of bovine serum albumin, causing a partial unfolding of the protein globule its exit to the surface of hydrophobic amino acids. Changing the pH of the solution in which the protein also affects the state of the protein, so there are multiple conformational states in which urea as a chemical effect on the conformation of bovine serum albumin, causing a partial unfolding of the protein globule of its exit to the surface of hydrophobic amino acids. Changing the pH of the solution in which the protein also affects the state of the protein, so there are multiple conformational states into which the serum albumin. The objective of our research was to study the effect of different protein concentrations and pH on the conformation of serum albumin. Very sensitive method for studying protein conformation are their own methods and probe fluorescence. The dependence of the effect of various factors on the fluorescence can be with a certain degree of probability suggest conformational transitions in proteins.
ULTRASOUND CONTROL IN BRACHIAL PLEXUS BLOCK ANESTHESIA (literature review)
Authors: Svistunov S. V. , Yurkovskiy A. M.
Published: September 2022

This is a review of the publications devoted to the techniques of brachial plexus nerve block anesthesia conducted under ultrasound control. There is a certain gap in the knowledge about the usage of ultrasound control for this kind of block anesthesia and this often leads to complications invoked after the mentioned manipulation.
EFFECT OF ATORVASTATIN ON HORMONE CONTENT IN BLOOD LIPOPROTEINS OF PATIENTS WITH ISCHEMIC HEART DISEASE
Authors: Osochuk S. S. , Buyanova S. V.
Published: September 2022

It has been established that blood lipoproteins of patients with ischemic heart disease transport cortisol and triiodothyronine but do not transport tetraiodothyronine. Atorvastatin does not influence the hormone content and their distribution in lipoproteins, but brings authentic differences in the formation of triiodothyronine transfer hormone-positive groups in 24 and 60 hours after its single application in men and women.
FLUORESCENCE STUDY OF CONFORMATIONAL CHANGES OF BOVINE SERUM ALBUMIN UNDER PEROXYNITRITE IN SOLUTION
Authors: Kornoushenko Yu. V. , Ignatenko V. A. , Avdeev P. A.
Published: September 2022

The effect of peroxynitrite on bovine serum albumin (BSA) calls forth the processes that lead to the destruction of its native structure. The degree of the destruction depends on the nature of the reactions occurring under the influence of peroxynitrite: if the substrate is passive in chemical terms, the effect of peroxynitrite is mediated through hydroxyl radicals. If the substrate is active, then taking into account the short lifetime of peroxynitrite, the latter is directly involved in the reaction with the substrate. Considering the varying amount of protein globule as depending on pH, its heterogeneous structure, one can assume the simultaneous contribution of the two mechanisms of peroxynitrite effect: both radical and ion. However, taking into account the reactivity of amino acids, one can surmise about the dominance of the peroxynitrite radical effect on the protein globule. Thus, peroxynitrite effects bovine serum albumin in a partially destructive way, which does not lead to its total denaturation.
INTERLEUKIN-6 AS A PROGNOSTIC FACTOR IN ACUTE MYELOBLASTIC LEUKEMIA IN ADULTS
Authors: Luitarevich O. G. , Krivenko S. I. , Belevtsev M. V.
Published: September 2022

Проведена оценка возможности использования показателя плазменного уровня ИЛ-6 и экспрессии рецептора к данному цитокину для прогнозирования течения и исхода при остром миелобластном лейкозе (ОМЛ). Установлено более чем десятикратное повышение плазменного уровня ИЛ-6 у больных ОМЛ до начала получения цитостатической терапии по сравнению со здоровыми людьми. Показатели плазменного уровня ИЛ-6 у больных ОМЛ не коррелировали с экспрессией рецептора к данному цитокину ни на иммунокомпетентных клетках, ни на бластах. Число T-клеток, несущих на своей поверхности CD126 в целом у больных было достоверно ниже, чем у здоровых доноров. Регистрируемое в исследуемой когорте больных ОМЛ статистически достоверное снижение числа Т-лимфоцитов, экспрессирующих CD126, формировалось, преимущественно, за счет показателей пациентов прогностически неблагоприятных групп. Была выявлена достоверная умеренная прямая корреляционная зависимость между числом опухолевых клеток, экспрессирующих CD126, и плотностью экспрессии данного рецептора. Число CD126-положительных бластов коррелировало также с уровнем лейкоцитов периферической крови, что подтверждает значительную роль ИЛ-6-опосредованных сигналов в опухолевой прогрессии при ОМЛ.
Assessment of Island Wide Distribution and Requirement of Biomedical Equipment for COVID-19 Case Management in Government Hospitals of Sri Lanka
Authors: Fernando G.H.S. , Gunasena B.A.H.M , Yapa Bandara A.S. , Panapitiya Lal
Published: September 2022

According to the World Health Organization, the critically ill patients of SARS-CoV-2 require mechanical ventilation as the virus (henceforth referred to as COVID-19), through a variety of mechanisms, disrupt the capacity for oxygenation of the infected. The availability of Oxygen for patients through mechanical means is thus an essential means of treatment, required for the effective management of COVID 19. Ergo, it is understood that all the COVID 19 treatment centers should equipped with pulse oxygen meters and a functioning oxygen supply system including single use oxygen delivery interfaces. In the Sri Lankan context however, the correct number of the available equipment list was not available in the databases of Ministry of Health, Sri Lanka. It is understood that the availability of a database of essential equipment is essential as it allows policy makers to make effective decisions and prescribe actions by assessing the readiness of medical institutions in facing the pandemic. As such, the aforementioned Ministry and the Deputy Director General Medical (DDG) MS 1) collected information on essential medical equipment in each relevant institute through a web-based system. The objective of this assessment was to collect information of medical equipment related to the efficient and effective management of COVID 19 patients of Government Hospitals. This assessment collected data only from the State of Sri Lanka, and as such, the subsequent terms Ministry of Health and Government Hospitals refer to the Ministry of Health Sri Lanka, and Government Hospitals in Sri Lanka, unless stated otherwise.
Pelatihan Pengisian E-Form Spt Tahunan 1770 UMKM Untuk Relawan Pajak
Authors: Hutapea Herti Diana , Manurung Amran , Nancy Nopeline
Published: September 2022

The purpose of this community service is to provide training or technical guidance on how to fill out the 1770 SMEs Annual SPT E-Form for tax volunteers in 2022 so that tax volunteers can educate the public on the importance of taxes and assist taxpayers to report their taxes specifically filling out the SPT E-form. 1770 SMEs. This training was conducted online on Friday, February 11, 2022, 08.00-10.00 WIB, which was attended by 64 participants. The implementation of this event started from the opening, prayer and training, video screenings and question and answer sessions and participant feebacks.
With this training, tax volunteers in 2022 can be trained in assisting SMEs taxpayers in educating the public about the importance of taxes, how to register NPWP, assisting taxpayers when they forget their passwords, in obtaining E-Fin and reporting the 1770 SMEs annual SPT with E-Form. And the existence of this training further equip tax volunteers in providing the best service to taxpayers, especially SMEs taxpayers. The implementation of this training still has technical problems because the training cannot be done in person because the process of implementing the training is online. However, based on feedback from the participants, even though there were technical obstacles, overall, the participants enthusiastically responded to every interaction with the speakers, they were able to clearly summarize the training carried out, so it can be concluded that the purpose of this service has been achieved.
Blagovna znamka Ljubljanske banke
Authors: Rendla Marta
Published: September 2022

Enotnost pojavljanja v javnosti  so v Ljubljanski banki z oblikovanjem blagovne znamke, ki so jo sestavljali celostna grafična podoba z razpoznavnim znakom/simbolom in imenom, hišni stil  in skupek vtisov bančnih storitev, oblikovali na začetku sedemdesetih let. Decembra 1971  so po zasnovi skupine vidnih grafičnih oblikovalcev sprejeli predlog grafičnega lika−stiliziran znak, ki sta ga sestavljali obliki z asociacijo na začetnici ˮl“ in “bˮ v poševni legi, za tipografijo črk pa so izbrali helvetico medium. Slog vseh vidnih nastopov je postopoma postal stalen in enoten po obliki, razporeditvi znaka v odnosu do napisa ter vseh drugih risanih ali tiskanih elementov.  Logotip, prisoten na različnih komunikacijskih nosilcih, kot so dopisne tiskovine, obrazci, poslovno-informativne publikacije, poslovni prostori, stavbe in njihova oprema, dostavna vozila in uniforme, je začel  kot splošni vizualni ali vidni vtis predstavljati posredni stik banke s strankami. S stiliziranim znakom LB in napisom imena se je začela predstavljati Ljubljanska banka in po njenem preoblikovanju in reorganiziranju leta 1978 celoten njen sistem bank. Na začetek sedemdesetih let, v leto 1970, segajo tudi prvi zametki hišnega stila.  Z izgradnjo stolpnice na  današnjem Trgu republike, kamor  so preselili osrednjo enoto Ljubljanske banke, so uvedli veliko novosti in nekatere rešitve so postale standardni elementi pri projektiranju bančnih objektov. Z dosledno uporabo poenotenih vizualnih oznak objektov in poslovnih prostorov je bila močno poudarjena identiteta bančnega prostora. Celostna podoba banke se je v praksi uveljavila kot pomembna prvina identitete celotnega sistema Ljubljanske banke.
El acceso a los trámites de la administración desde los pequeños ayuntamientos
Authors: Clemente Martínez Jaime
Published: September 2022

Los municipios de menos de 5.000 habitantes en España suponen la mayoría de la planta municipal, con lo cual los ayuntamientos se convierten en la «carta de presentación» de la administración pública ante la ciudadanía, ya que esta acude a los consistorios locales para preguntar sobre cualquier trámite que tenga previsto realizar ante cualquier administración.
Las complejas estructuras administrativas hacen que para la ciudadanía realizar un trámite resulte en ocasiones una tarea excesivamente complicada. Por ello, se pretende exponer cómo la adecuada configuración de los trámites administrativos y el establecimiento de mecanismos adecuados para informar y asesorar a la ciudadanía sobre los mismos resulta una labor esencial para que se logre un buen gobierno local y la correcta satisfacción del interés general constitucionalmente previsto.
Derecho de acceso: Dos novedades autonómicas en 2022 y una tercera que no pudo ser
Authors: Fernández Ramos Severiano
Published: September 2022

El objeto de este comentario es dar cuenta de las novedades en relación con la ordenación del derecho de acceso a la información pública introducidas por dos normas autonómicas, de diverso rango y alcance, curiosamente aprobadas en la misma fecha de 13 de abril de 2022 en la Comunidad Valenciana (Ley 1/2022, de 13 de abril) y La Rioja (Decreto 14/2022, de 13 de abril), así como utilizar, a modo de contraste, el malogrado proyecto de ley de fines de 2021 de Castilla y León. En cualquier caso, todas estas normas son expresivas de la continua evolución del régimen jurídico de la transparencia pública.
FAKTOR – FAKTOR YANG BERHUBUNGAN DENGAN TUMBUH KEMBANG ANAK USIA 1 – 3 TAHUN DI DESA KAYU LAUT KECAMATAN PANYABUNGAN SELATAN KABUPATEN MANDAILING NATAL TAHUN 2020
Authors: Lubis Nurkholidah
Published: September 2022

Growth is a measure of physical maturity. It is characterized by an increase in the size of the body and its different organs and development is an increase in the ability to structure and function more complex bodies in a regular pattern. According to UNICEF in 2005, data was obtained that the incidence of growth and development disorders in children under five, especially motor development disorders, was obtained 23.5% / 5 million children experiencing disorders. The purpose of this study was to determine the factors associated with the growth and development of children aged 1 - 3 years in the village of Kayu Laut. This research is an analytical observation using a cross-sectional design, is descriptive by distributing questionnaires and by using accidental sampling, with the number of sample of 95 respondents. The results of the research conducted in the village of Kayu Laut, South Panyabungan District, Mandailing Natal Regency, were obtained based on the sex of the majority of the female gender as many as 59 people (41.1%) male gender minority as many as 36 people (37.9%) based on the order of the children. majority order 1-2 as many as 48 people (50.5%) minority order> 2 as many as 47 people (49.5%) based on poor nutritional status as many as 58 people (61.1%) good minority as many as 37 people (38.9 %) based on the majority of incomplete immunization status as many as 77 people (81.1%) complete minority as many as 18 people (18.9%) based on the socioeconomic status of the majority as many as 83 people (87.4%) high minority as many as 12 people (12 , 6%) based on parenting style, the majority of bad supervision were 74 people (77.9%) minority good supervision was 21 people (22.1%) based on the community, the majority of the community was healthy, as many as 65 people (68.4%), the minority was unhealthy as many as 30 people (31.6%) The results of research on 95 children aged 1-3 years, the factors that influence children's growth and development are immunization status with p-value = 0.023 and parenting with p-value = 0.034, the most dominant variable affecting children's growth and development is parenting. , it is suggested for the public to always pay attention to the growth and development of their children to produce good, smart, healthy and intelligent children
HUBUNGAN PENGETAHUAN SISWA DENGAN TINDAKAN PENYALAHGUNAAN NAPZA DI SMK TUNAS PELITA BINJAI
Authors: Sembiring Nindya Anggiani
Published: September 2022

Penyalahgunaan narkoba adalah pemakaian non medical barang haram narkotik dan obat-obatan adiktif yang dapat merusak kesehatan. Berbagai jenis narkoba yang sering disalahgunakan adalah tembakau, alkohol, obat-obat terlarang dan zat yang dapat menyebabkan ketergantungan, jika dihentikan maka pemakai akan sakaw. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan siswa dengan tindakan penyalahgunaan NAPZA di SMK Tunas Pelita Binjai. Jenis penelitian ini merupakan penelitian survey bersifat analitik dengan pendekatan cross sectional. Sampel sebesar 111 siswa, yang diambil dengan menggunakan teknik random sampling. Variabel yang diukur adalah pengetahuan siswa mengenai NAPZA dan tindakan penyalahgunaan NAPZA dengan menggunakan kuesioner. Hasil Uji statistik yang dilakukan dengan menggunakan uji Chi-Square diperoleh nilai P-value sebesar 0,008 untuk pengetahuan siswa dengan tindakan penyalahgunaan NAPZA. Karena nilainya lebih kecil dari α = 0,05 maka Ho ditolak artinya Ada Hubungan Pengetahuan Siswa Dengan Tindakan Penyalahgunaan NAPZA di SMK Tunas Pelita Binjai. Diharapkan dari penelitian ini agar  siswa lebih meningkatkan pengetahuannya mengenai bahaya NAPZA.
EFEKTIFITAS REBUSAN DAUN SIRSAK TERHADAP PENURUNAN SKALA NYERI PADA PENDERITA GOUT ARTHRITIS
Authors: Hasibuan Devi Chairani , Simamora Febrina Angraini
Published: September 2022

Gout Arthritis adalah suatu proses inflamasi yang terjadi karena deposisi kristal asam urat pada jaringan sekitar sendi. Dari hasil penelitian terdapat kandungan dalam daun sirsak yang mampu mengurangi rasa nyeri yaitu senyawa tannin, resin dan crytallizable magostineyang mampu mengatasi nyeri sendi pada penyakit gout. Tujuan penelitian ini adalah untuk mengetahui efektifitas rebusan daun sirsak terhadap penurunan skala nyeri pada penderita gout. Desain penelitian yang digunakan adalah quasy experiment. Penelitian dilakukan didesa Sihepeng dengan melibatkan 30 responden, dengan 15 responden menjadi kelompok kontrol dan 15 responden menjadi kelompok eksperimen. Analisa data yang digunakan adalah uji wilcoxon,dan uji mann whitney. Hasil uji wilcoxon pada kelompok eksperimen  didapatkan nilai p=0.000, dan pada kelompok kontrol didapatkan nilai p=0.76. Hasil uji mann whitney  menunjukkan adanya pengaruh yang signifikan pada skala  nyeri penderita gout arthitis sesudah pemberian rebusan daun sirsak pada kelompok eksperimen, dengan nilai p=0.000. Hasil penelitian ini merekomendasikan konsumsi rebusan daun sirsak pada penderita gout arthritis untuk menurunkan skala nyeri.
A Numerical reassessment of the Gulf of Mexico carbon system in connection with the Mississippi River and global ocean
Authors: Zhang Le , Xue Z. George
Published: September 2022

Abstract. Coupled physical–biogeochemical models can fill the
spatial and temporal gap in ocean carbon observations. Challenges of
applying a coupled physical–biogeochemical model in the regional ocean
include the reasonable prescription of carbon model boundary conditions,
lack of in situ observations, and the oversimplification of certain
biogeochemical processes. In this study, we applied a coupled
physical–biogeochemical model (Regional Ocean Modelling System, ROMS) to the
Gulf of Mexico (GoM) and achieved an unprecedented 20-year high-resolution
(5 km, 1/22∘) hindcast covering the period of 2000 to 2019. The
biogeochemical model incorporated the dynamics of dissolved organic carbon
(DOC) pools and the formation and dissolution of carbonate minerals. The
biogeochemical boundaries were interpolated from NCAR's CESM2-WACCM-FV2
solution after evaluating the performance of 17 GCMs in the GoM waters. Model
outputs included carbon system variables of wide interest, such as
pCO2, pH, aragonite saturation state (ΩArag), calcite
saturation state (ΩCalc), CO2 air–sea flux, and carbon burial
rate. The model's robustness is evaluated via extensive model–data
comparison against buoys, remote-sensing-based machine learning (ML)
products, and ship-based measurements. A reassessment of air–sea CO2
flux with previous modeling and observational studies gives us confidence
that our model provides a robust and updated CO2 flux estimation, and
NGoM is a stronger carbon sink than previously reported. Model results
reveal that the GoM water has been experiencing a ∼ 0.0016 yr−1 decrease in surface pH over the past 2 decades, accompanied by a
∼ 1.66 µatm yr−1 increase in sea surface
pCO2. The air–sea CO2 exchange estimation confirms in accordance with several
previous models and ocean surface pCO2 observations that the
river-dominated northern GoM (NGoM) is a substantial carbon sink, and the
open GoM is a carbon source during summer and a carbon sink for the rest of
the year. Sensitivity experiments are conducted to evaluate the impacts of
river inputs and the global ocean via model boundaries. The NGoM carbon
system is directly modified by the enormous carbon inputs (∼ 15.5 Tg C yr−1 DIC and ∼ 2.3 Tg C yr−1 DOC) from the
Mississippi–Atchafalaya River System (MARS). Additionally,
nutrient-stimulated biological activities create a ∼ 105 times
higher particulate organic matter burial rate in NGoM sediment than in the
case without river-delivered nutrients. The carbon system condition of the
open ocean is driven by inputs from the Caribbean Sea via the Yucatan Channel
and is affected more by thermal effects than biological factors.