bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis Prediction of Prambanan Temple Visitors with Fuzzy Time Series Chen Model and Seasonal Auto Regressive Integrated Moving Average (SARIMA) Model
Authors: Artika Rohmah , Setiawan Adi , Setyowisnu Glagah Eskacakra , Uminasiah Siti , Prihantini
Published: April 2021

The number of visitors in tourist attractions are almost always changes each time, even for tourist attractions that are already well-known among local and foreign people, usually will tend to increase at certain times, as in the Prambanan Temple. Based on data from TWC (Taman Wisata Candi) unit office, the number of visitors of Prambanan Temple during holidays at the end of 2018 increased by 8% from the previous year. Because of its increase, the manager of tourist attractions must always try to provide the best service. Therefore, the manager of Prambanan Temple needs to know the prediction of the number of visitors in the future so that they can prepare services and innovations to increase its attractiveness. The data of Prambanan Temple visitors number is seasonal, so the visitors number prediction at Prambanan Temple will be determined using the method for seasonal data. This research tries to compare the two methods, namely Fuzzy Time Series Chen Model and Seasonal Auto Regressive Integrated Moving Average (SARIMA) Model. The results of these methods are the visitors number prediction with different errors, so it can be seen which method is better between the two.
A Method for Precision Surgical Implantation and Probe Insertion in Sprague-Dawley Rat Brain
Authors: Shaimi Asma Ulhusna , Aasim Wan Raihana Wan , Hmad Wan Amir Nizam Wan A , Abdullah Hasmah
Published: April 2021

Motorized stereotaxic is an advanced tool for surgery and implantation of cannula and electrodes in neuroscience. Stereotaxic surgery and implantation has become increasingly important tool, applied in many experiments. The goal in this present study to determine the surgical implantation and probe insertion at the target location accurately and precisely using motorized stereotaxic. In this study, the method allowed to evaluate the DHEAS fluorescence level through in vivo imaging approach at the target region in the hippocampus rat brain. This present study also described the surgical implantation and probe insertion by motorized stereotaxic as the precise and accurate techniques than conventional stereotaxic procedures. With the rat brain atlas by Paxinos and Watson (2004), the imaging approach can be evaluated precisely at the target location corresponding surgical implantation and probe insertion techniques.
Bioplastic Biodegradation Based on Ganyong Umbi States with Addition of Sorbitol and CMC (Carboxy Methil Cellulose) In Soil Media
Authors: Ma’arif Lukman , Fitrass Ulia , Sedyadi Endaruji
Published: April 2021

Bioplastics made using the basic ingredients of canna tuber starch with sorbitol plasticizer and the addition of CMC variations have been carried out. This study aims to understand the effect of adding CMC to the mechanical properties and biodegradability of bioplastics in soil media. This research was carried out with 4 stages of work namely, extraction of starch from canna tubers, synthesis of bioplastic manufacturing using the blending method, testing mechanical properties in the form of thickness, tensile strength, elongation, and young modulus. Characteristics of functional groups have been tested using FTIR and bioplastic biodegradability testing has been carried out on soil media for 21 days by looking at weight loss from bioplastics. The variation of adding CMC used is 0; 0.25; 0.5; 0.75; 1; 1.25; 1.5 and 2 grams. The best mechanical properties are produced with thickness of 0.0795 mm, tensile strength of 27.53 MPa, elongation of 3.018% and young modulus of 885.66 MPa. The results of bioplastic biodegradation testing on soil media for 21 days showed that bioplastics made were biodegradable. Reduction of bioplastic mass in soil media by 86,032%.
Development of The Story Book “Negeri Hastinapura” to Instill Patriotism Value in Primary School Student
Authors: Komalasari Mahilda Dea , Widyaningsih Nina , Wihaskoro Ahmad Mabruri
Published: April 2021

The phenomenon of radicalism in Indonesia is still rife, such as the bombing of the church in Surabaya, the shootout with radicalist in Yogyakarta, are some examples of recent events of radicalism. Likewise, the events of radicalism in the world, the radical group ISIS is a group that often carries out acts of radicalism and ISIS propaganda that should be watched out so as not to damage peace in Indonesia. This shows that the importance of efforts to overcome radicalism, namely through the prevention of the development of radicalism. The background of this research is motivated by the importance of preventing radicalism from developing among primary school students through instilling the values of patriotism. The story book "Negeri Hastinapura" was chosen because wayang can be used as an educational tool, because it contains elements of truth, justice, purpose, obedience, loyalty, heroism, spiritual, psychological, philosophical and all aspects of human disposition and its problems (Tofani, 2013). “Negeri Hastinapura” is the country contained in the Mahabharata puppet story. This story book "Negeri Hastinapura" takes place when it is led by Prabu Yudistira, where the country is safe, peaceful, and the community is prosperous, so students can be taught exemplary values and instilling the values of patriotism. The development of the story book "Negeri Hastinapura" was designed using the development research (R&D) method using the subject of primary school students. The story book "Negeri Hastinapura" was tested in primary schools, SDIT Insan Utama, Yogyakarta. The results of the analysis of the value of patriotism showed that the t-test score was 5.350 with Sig. 0,000. This shows that there is a significant increase in the value of students' patriotism between before and after learning using the story book "Negeri Hastinapura".
Design of English Learning Application for Children Early Childhood
Authors: Saputra Very Hendra , Pasha Donaya , Afriska Yolanda
Published: April 2021

Early childhood development includes several aspects such as physical, motor, language, social and cognitive. Cognitive factors are important role because most learning activities are always related to thinking and remembering problems. Besides language development is very important, it is because language is a communication tool of children with their environment, with good communication it will result in good interactions. Therefore, children need to be given the right stimulus so that during the child's growth and development to the maximum. One stimulus that can be given for cognitive development and language of early childhood is by providing an interesting medium, because in the development of early childhood the way of thinking requires visualization of abstract thinking. The purpose of this research is to design an application of learning English for mobile-based early childhood which is expected to be used as an \alternative as a medium to assist cognitive development and communication of early childhood. English based learning applications for mobile children are made with Construct 2 software. The development method uses the Multimedia Development Life Cycle. While testing the application using ISO 9126, the results of testing the quality of the application using ISO 9126 which includes the Functionality and Usability characteristics obtained Functionality test results obtained value of 100%, and the Usability test results obtained value of 91.11% so it can be concluded that the design of English learning applications is appropriate to be used as a medium to assist cognitive development and communication of early childhood.
Grebeg Sudiro as a form of Harmonization of Ethnic Javanese and Ethnic Chinese in Sudiroprajan Village, Surakarta
Authors: Muhammad Ammar
Published: April 2021

Local wisdom is a form of the culture of the past should be continuously used as a handle for a living. Culture in Indonesia since ancient times become habit in behave in society. The existence of the culture surrounding this society will bring a unity in diversity and become its own characteristics within the community. For example, as we will describe are Grebeg Sudiro which is acculturation of Javanese and Chinese culture. This research uses qualitative-descriptive research methods. The purpose of the use of this method is to uncover the facts, circumstances, phenomenon, variable, and circumstances that occur when doing research. The source we got using the method of interview, observation and literacy. Grebeg Sudiro was a tradition of celebration to welcome the Chinese new year or Imlek in Surakarta, Central Java. Grebeg Sudiro was born as a form of preservation of harmony between ethnic happens in Kampung Sudiroprajan. Grebeg Sudiro contains a number of activities, such as the ceremony of the Umbul Mantram, the Carnival culture, race copyright Creations Lanterns, decorative River boat tour of Pepe, bazar, Sudiroprajan and potential on the cover with the celebration Fireworks.
Construction Meaning of Bude Trieng Toys (Rifles) in Physics: Traditional Toys
Authors: Maknuni Jauharil , Sabaruddin
Published: April 2021

Physics is closely related to human life, without realizing we have implemented it in daily life such as when working, walking and other activities, not only adults but also children. When talking about physics we definitely think that physics was born from the west. Before the development of the west in the 9th Century AD, Physics was used in society, especially the people of Aceh. It is undeniable that technology has developed more rapidly now. Technology was created to facilitate human affairs. There are innumerable kinds of technologies. One example of a very popular technology is gadgets. Every person uses gadgets with modern technology such as smart phones, Children have now become active consumers in which many electronic products and gadgets make children the target market for their toys. Before the era of sophisticated technology one of the toys chosen by most children was the Bude Trieng (shotgun). Bude Trieng is marked by playing activities both by himself and other peer groups. i is one toy that quite safe and most popular with children. This type of toy is made from bamboo using paper bullets or boh ram. The method of application is insert boh Ram's bullet in the base of the bude trieng, the ram bullet fills the entire circle of the trieng bude hole, the air inside the Bude trieng will automatically be restrained and cannot come out. The air that is held in the middle of the trieng bude will produce pressure when one of the bullets is pushed and will make a sound from the bude trieng. The purpose of this research is to study the construction of the meaning of bude trieng culture in physics. The research method used was a descriptive qualitative research to describe the relationship between the bude trieng and physics.
Analysis of Growth Patterns of Islamic Boarding School Business Architecture
Authors: Granita Selvi Dwi , Kristi Vika Anindya , Asyarofi Sonia Desy , Yaqin Muhammad Ainul
Published: April 2021

The growth pattern of boarding schools is the process of growing boarding schools from the simplest type to the highest type so as to produce more complex business processes. The growth of business processes can affect the growing needs of Islamic boarding schools. Currently there is no modeling of the growth patterns of Islamic boarding schools, so that the needs of Islamic boarding schools have not been well predicted. Therefore, an analysis of the growth patterns of business architecture in Islamic boarding schools is made so that the growth of Islamic boarding school business architecture can be well predicted. Analysis of the growth pattern of the business architecture of this Islamic boarding school uses cellular automata analysis methods. The parameter that triggers growth is the number of students, from this number can trigger other growth such as the number of teachers, the number of dormitories, the number of staff and several other supporting facilities. The final results obtained from this study are a form of growth patterns in boarding school business architecture represented in the form of graphs that can provide information to be used as academic guidelines in the growth of boarding school business architecture needs.
Gemeinsinn und Solidarität: Motivation und Wirkung von Freiwilligenarbeit
Authors: Kals Elisabeth , Strubel Isabel T. , Güntert Stefan T.
Published: April 2021

Freiwilligenarbeit ist eine zentrale Säule der Bürgergesellschaft und fördert wechselseitige Teilhabe. In diesem Text wird ein Überblick über die psychologische Motivforschung zur Freiwilligenarbeit gegeben. Es werden konkrete Empfehlungen abgeleitet, wie sich entsprechende Commitments und Verhaltensweisen fördern lassen.
Managementunterstützung zur Besuchersteuerung in Bibliotheken: Reportingprozesse im Coronakontext
Authors: Köppen Veit , Lücke Christine
Published: April 2021

Mit der notwendigen Besuchersteuerung im Kontext der Covid-19-Pandemie ergab sich für Bibliotheksleitungen eine Vielzahl von Entscheidungen in einem unbekannten, dynamischen Umfeld. Neue Werkzeuge können dabei nicht nur unmittelbar das operative Tagesgeschäft erleichtern, sondern als zusätzliche Informationsquellen für die nächsten Entscheidungsschritte dienen. Kennzahlen quantifizieren und verdichten Informationen und können für Steuerungsprozesse eingesetzt werden. An der Universitätsbibliothek Magdeburg wurde eine leichtgewichtige Reportinglösung für die Bibliotheksleitung entworfen, die es ermöglicht, kurzfristig und gleichzeitig adäquat auf die Anforderungen und Rahmenbedingungen einzugehen.
Ein Ort des sozialen Miteinanders: Teilhabeorientierte Bibliotheksarbeit in der Zentral- und Landesbibliothek Berlin
Authors: Galka Judith , Haddad Jolina , Hartung Lea
Published: April 2021

Der Beitrag erkundet praxisgeleitet die wichtige Rolle, die teilhabeorientierte Bibliotheksarbeit für die Entwicklung und Zukunft einer Öffentlichen Bibliothek hat. Er stellt eine Systematik der Partizipation in der Programmgestaltung und den Community-Ansatz anhand von Beispielen vor. Anhand von zwei ausführlichen Beispielen werden Herangehensweisen, Chancen, Konsequenzen und Möglichkeitsgrenzen von teilhabeorientierter Bibliotheksarbeit aufgezeigt.
Ehrensache – Freiwillig für die Stadtbücherei Münster
Authors: Schelletter Christiane , Topp Carsten
Published: April 2021

Der Freiwilligenarbeit der Stadtbücherei Münster ist dieser Beitrag gewidmet. Die vielfältigen Facetten werden am Beispiel des „Freiwilligenmodells“ zum Erhalt der Stadtteilbibliotheken, den Vorlesepatenschaften in den Büchereien, aber auch außerhalb in Schulen und Kitas oder mittels Bookbike an öffentlichen Orten (Spielplätze etc.) beschrieben. Hinzu kommen Förderverein und Freundeskreis, die eine Vielzahl von Projekten (Bücherflohmärkte, offene Bücherregale, Jahreszeitenfeste, Büchereigartenpflege) unterstützen.
Adolescent medicine during specialized paediatric training: the past, the present and the future
Authors: Cristóvão Ferreira Ana , Videira da Silva António , Freira Sílvia , Fonseca Helena
Published: April 2021

Objectives

Paediatricians increasingly need to take care of adolescents, a life stage with specific needs, however many of them admit a limitation in their medical education regarding Adolescent Medicine. The objective of this paperwork is to evaluate the formative model adopted in the Department of Paediatrics, Hospital de Santa Maria, and assess the impact of the training in Adolescent Medicine.

Methods

We surveyed the current Paediatric Residents and those who graduated as Paediatricians from the Department in the past five years, in order to get feedback on the one-month compulsory training at the Adolescent Medicine Division during their Residency.

Results

Both groups considered it as a very interesting/useful training. Paediatricians considered that the training had an insufficient duration, with statistical difference comparing to the current Residents’ opinion. Conversely, Residents considered more often that the acquired competencies would be useful in their future clinical practice, when compared to Paediatricians.

Conclusions

In order to potentiate learning and training during such a short period of time, a few changes were identified as beneficial to be implemented.
Effects of soy flour types and extrusion-cooking conditions on physicochemical, microstructural and sensory characteristics of puffed rice snack base
Authors: Choi Ok-Ja , Zhao Chang-Cheng , Ameer Kashif , Eun Jong-Bang
Published: April 2021

The physicochemical properties of puffed rice snack base (PRSB) prepared via extrusion cooking under various feed moisture contents and screw speeds were investigated. The moisture content, screw speed, and soy flour type significantly (p < 0.05) affected the physicochemical properties of PRSB viz; size, density, porosity, color, breaking strength, crystallinity, water absorption index (WAI) and water solubility index (WSI). While, a slight effect on pasting properties was observed between PRSB added with defatted and full-fat soy flour, respectively. Soy flour lipids significantly (p < 0.05) influenced extrusion cooking conditions especially at high screw speed and feed moisture content. The result revealed that extrusion cooking with addition of full-fatty soy flour can be exploited as a viable method to produce PRS with a high expansion ratio and low breaking strength at recommended extrusion conditions of feed moisture content of 19 % and screw speed of 300 rpm.
Writing History Under Empire: TheBabylonian ChronicleReconsidered
Authors: Waerzeggers Caroline
Published: April 2021

This article proposes to read theBabylonian Chronicleas historical literature. It argues that the text was composed in response to Babylonia’s integration in the Persian Empire. The text presents itself as a self-conscious departure from the chronographic tradition by tracing the roots of Babylon’s fate to the mid-eighth century, when a triangle of power is said to have emerged between Assyria, Babylonia and Elam—a configuration that reduced the Babylonian monarch to inaction and incompetence from the very start.
Does the crested porcupine select coppice forest? Habitat preference and activity patterns of a large rodent in the Lago di Vico Natural Reserve
Authors: Luzi Giulia , Mori Emiliano , Puddu Giuseppe , Zapparoli Marzio
Published: April 2021

The crested porcupine Hystrix cristata L. is a large rodent, which mainly occurs in agro-forestry ecosystems in Italy. In this study, we modelled the occupancy of this species in forest ecosystems, to identify environmental characteristics affecting its presence. The study was conducted at Lago di Vico Natural Reserve (Latium, Central Italy) in 2018–2019. The sampling design included a 1 km2 grid, where 263 detections were recorded at 39 out of 57 camera-trap points. Dendroauxometric data were collected at each site as covariates in the statistical models. According to our best occupancy model, the crested porcupine mostly occurs in habitats not totally covered by forests, but composed by mixed landscape patches both for the land use (crops, woods) and for the coverage (forested areas, open areas, bushes). We also analysed activity rhythms of the crested porcupine across seasons and in relation to the moon phases. The analysis of 543 videos showed that crested porcupine is strictly nocturnal throughout the year and avoided bright nights, despite the local absence of potential predators.
Equilibria Under Negligence Liability
Authors: Feldman Allan , Singh Ram
Published: April 2021

In many accident contexts, the expected accident harm depends on observable as well as unobservable dimensions of the precaution exercised by the parties involved. The observable dimensions are commonly referred to as the ‘care’ levels and the unobservable aspects as the ‘activity’ levels. In a seminal contribution, Shavell, S (1980). Strict liability versus negligence. J. Leg. Stud. 9: 1–25 extended the scope of the economic analysis of liability rules by providing a model that allows for the care as well as activity level choices. Subsequent works have used and extended Shavell’s model to predict outcomes under various liability rules, and also to compare their efficiency properties. These works make several claims about the existence and efficiency of equilibria under different liability rules, without providing any formal proof. In this paper, we re-examine the prevalent claims in the literature using the standard model itself. Contrary to these prevalent claims, we show that the standard negligence liability rules do not induce equilibrium for all of the accident contexts admissible under the model. Under the standard model, even the ‘no-fault’ rules can fail to induce a Nash equilibrium. In the absence of an equilibrium, it is not plausible to make a claim about the efficiency of a ruleper-seorvis-a-visother rules. We show that even with commonly used utility functions that meet all of the requirements of the standard model, the social welfare function may not have a maximum. In many other situations fully compatible with the standard model, a maximum of the social welfare function is not discoverable by the first order conditions. Under the standard model, even individually optimum choices might not exist. We analyze the underlying problems with the standard model and offer some insights for future research on this subject.
Debate Reaction Ideal Points: Political Ideology Measurement Using Real-Time Reaction Data
Authors: Argyle Daniel , Argyle Lisa P. , Eidelman Vlad , Resnik Philip
Published: April 2021

Ideal point models have become a powerful tool for defining and measuring the ideology of many kinds of political actors, including legislators, judges, campaign donors, and members of the general public. We extend the application of ideal point models to the public using a novel data source: real-time reactions to statements by candidates in the 2012 presidential debates. Using these reactions as inputs to an ideal point model, we estimate individual-level ideology and evaluate the quality of the measure. Debate reaction ideal points provide a method for estimating a continuous, individual-level measure of ideology that avoids survey response biases, provides better estimates for moderates and the politically unengaged, and reflects the content of salient political discourse relevant to viewers’ attitudes and vote choices. As expected, we find that debate reaction ideal points are more extreme among respondents who strongly identify with a political party, but retain substantial within-party variation. Ideal points are also more extreme among respondents who are more politically interested. Using topical subsets of the debate statements, we find that ideal points in the sample are more moderate for foreign policy than for economic or domestic policy.
Rethinking sustainability in seafood
Authors: McKuin Brandi , Watson Jordan T. , Stohs Stephen , Campbell J. Elliott
Published: April 2021

Sustainability is a common goal and catchphrase used in conjunction with seafood, but the metrics used to determine the level of sustainability are poorly defined. Although the conservation statuses of target or nontarget fish stocks associated with fisheries have been scrutinized, the relative climate impacts of different fisheries are often overlooked. Although an increasing body of research seeks to understand and mitigate the climate forcing associated with different fisheries, little effort has sought to integrate these disparate disciplines to examine the synergies and trade-offs between conservation efforts and efforts to reduce climate impacts. We quantified the climate forcing per unit of fish protein associated with several different U.S. tuna fishing fleets, among the most important capture fisheries by both volume and value. We found that skipjack tuna caught by purse seine, a gear type that is often associated with relatively high bycatch of nontarget species, results in lower climate forcing than all other sources of proteins examined with the exception of plants. Conversely, skipjack tuna caught by trolling, a gear type that is often associated with relatively low bycatch of nontarget species, generates higher climate forcing than most other protein sources with the exception of beef. Because there is a range of selectivity and climate forcing impacts associated with fishing gears, examining the trade-offs associated with bycatch and climate forcing provides an opportunity for broadening the discourse about the sustainability of seafood. A central goal of more sustainable seafood practices is to minimize environmental impacts, thus mitigation efforts—whether they target conservation, habitat preservation, or climate impacts—should consider the unintended consequences on fisheries conservation.
Transcription factor immunohistochemistry in the diagnosis of pituitary tumours
Authors: Lenders Nèle F , Wilkinson Adam C , Wong Stephen J , Shein Tint T , Harvey Richard J , Inder Warrick J , Earls Peter E , McCormack Ann I
Published: April 2021

Objective

The clinical utility and prognostic value of WHO 2017 lineage-based classification of pituitary tumours have not been assessed. This study aimed to (1) determine the clinical utility of transcription factor analysis for classification of pituitary tumours and (2) determine the prognostic value of improved lineage-based classification of pituitary tumours.

Methods

This was a retrospective evaluation of patients who underwent surgical resection of pituitary tumours at St Vincent’s Public and Private Hospitals, Sydney, Australia between 1990 and 2016. Included patients were at least 18 years of age and had complete histopathological data, forming the 'histological cohort'. Patients with at least 12 months of post-surgical follow-up were included in the subgroup 'clinical cohort'. The diagnostic efficacy of transcription factor immunohistochemistry in conjunction with hormone immunohistochemistry was compared with hormone immunohistochemistry alone. The prognostic value of identifying 'higher-risk' histological subtypes was assessed.

Results

There were 171 patient tumour samples analyzed in the histological cohort. Of these, there were 95 patients forming the clinical cohort. Subtype diagnosis was changed in 20/171 (12%) of tumours. Within the clinical cohort, there were 21/95 (22%) patients identified with higher-risk histological subtype tumours. These were associated with tumour invasiveness (P = 0.050), early recurrence (12–24 months, P = 0.013), shorter median time to recurrence (49 (IQR: 22.5–73.0) vs 15 (IQR: 12.0–25.0) months, P = 0.005) and reduced recurrence-free survival (P = 0.031).

Conclusions

Application of transcription factor analysis, in addition to hormone immunohistochemistry, allows for refined pituitary tumour classification and may facilitate an improved approach to prognostication.
Metabolic disease and adverse events from immune checkpoint inhibitors
Authors: Leiter Amanda , Carroll Emily , De Alwis Sonia , Brooks Danielle , Ben Shimol Jennifer , Eisenberg Elliot , Wisnivesky Juan P , Galsky Matthew D , Jane Gallagher Emily
Published: April 2021

Objective

Obese and overweight body mass index (BMI) categories have been associated with increased immune-related adverse events (irAEs) in patients with cancer receiving immune checkpoint inhibitors (ICIs); however, the impact of being overweight in conjunction with related metabolic syndrome-associated factors on irAEs have not been investigated. We aimed to evaluate the impact of overweight and obese BMI according to metabolic disease burden on the development of irAEs.

Design and methods

We conducted a retrospective observational study of patients receiving ICIs at a cancer center. Our main study outcome was development of ≥grade 2 (moderate) irAEs. Our main predictor was weight/metabolic disease risk category: (1) normal weight (BMI 18.5–24.9 kg/m2)/low metabolic risk (<2 metabolic diseases (diabetes, dyslipidemia, hypertension)), (2) normal weight/high metabolic risk (≥2 metabolic diseases), (3) overweight (BMI ≥ 25 kg/m2)/low metabolic risk, and (4) overweight/high metabolic risk.

Results

Of 411 patients in our cohort, 374 were eligible for analysis. Overall, 111 (30%) patients developed ≥grade 2 irAEs. In Cox analysis, overweight/low metabolic risk was significantly associated with ≥grade 2 irAEs (hazard ratio (HR): 2.0, 95% confidence interval (95% CI): 1.2–3.4) when compared to normal weight/low metabolic risk, while overweight/high metabolic risk (HR: 1.3, 95% CI: 0.7–2.2) and normal weight/high metabolic risk (HR: 1.5, 95% CI: 0.7–3.0) were not.

Conclusions

Overweight patients with fewer metabolic comorbidities were at increased risk for irAEs. This study provides an important insight that BMI should be evaluated in the context of associated metabolic comorbidities in assessing risk of irAE development and ICI immune response.
Genomic alterations impact cell cycle-related genes during prostate cancer progression
Authors: Ben-Salem Salma , Venkadakrishnan Varadha Balaji , Heemers Hannelore V
Published: April 2021

The recent genomic characterization of patient specimens has started to reveal the landscape of somatic alterations in clinical prostate cancer (CaP) and its association with disease progression and treatment resistance. The extent to which such alterations impact hallmarks of cancer is still unclear. Here, we interrogate genomic data from thousands of clinical CaP specimens that reflect progression from treatment-naïve, to castration-recurrent, and in some cases, neuroendocrine CaP for alterations in cell cycle-associated and -regulated genes, which are central to cancer initiation and progression. We evaluate gene signatures previously curated to evaluate G1-S and G2-M phase transitions or to represent the cell cycle-dependent proteome. The resulting CaP (stage)-specific overview confirmed the presence of well-known driver alterations impacting, for instance, the genes encoding p53 and MYC, and uncovered novel previously unrecognized mutations that affect others such as the PKMYT1 and MTBP genes. The cancer dependency and drugability of representative genomically altered cell cycle determinants were verified also. Taken together, these analyses on hundreds of often less-characterized cell cycle regulators expand considerably the scope of genomic alterations associated with CaP cell proliferation and cell cycle and isolate such regulatory proteins as putative drivers of CaP treatment resistance and entirely novel therapeutic targets for CaP therapy.
The Premiere of Beethoven’s Symphony No. 9 in Belgrade
Authors: Dujović Marijana
Published: April 2021

The premiere of Beethoven’s Symphony No. 9 in Belgrade, capital of Serbia, was in 1910. The situation in Belgrade, around 1910 in the field of musical culture, and culture in general, was not so good as in other parts of Europe. In a society with not so many professional musicians, where amateurs were the main carriers of musical life, the young composer and conductor Stanislav Binički, who had come back from his studies in Munich decided to organize with a group of enthusiasts the premiere of Beethoven’s Ninth Symphony. In this article I will represent the musical situation in the capital around 1910 and show what this premiere brought to audiences and musicians in Belgrade.
The Climate Emergency in the Spanish Media and the «Decalogue of Recommendations for Reporting on Climate Change»
Authors: Teso-Alonso Mª-Gemma , Morales-Corral Enrique , Gaitán-Moya Juan-Antonio
Published: April 2021

In the last two years, since the publication of the latest IPCC reports (IPCC, 2018 & 2020), greater alarm in the scientific, media and social areas has elevated the climate crisis to an emergency level. The social perception of the risk for people and the communication of this emergency has become a complex social phenomenon being constantly updated. This article sets out the results of the content analysis for communications on climate change (CC) in the main Spanish press, radio and television media and their respective Twitter accounts. A structural sampling has been used to identify the different media and supports to be analyzed. The time segment of the Climate Week NYC 2019 was chosen because key dates for the objectives of the study converge there. The Decalogue of Recommendations for Reporting on Climate Change (ECODES, 2018)”, endorsed by over 80 media sources in Spain in the years 2018 and 2019, brings together a series of variables for climate change communication analysis including outstanding concepts and values. The results confirm that the media discourse on CC is worded in accordance with the different social, scientific, and political agendas which interact with the media agenda. Particularities have been found in terms of how the information has been treated and the representations of CC, depending on the type of media analyzed. The evaluation also permits the identification of common elements that characterize the media discourse and shows how the acceleration of the six social tipping interventions (STI) identified by Otto et al. (2020) requires the strategic cooperation of the media for social transformation.
Netflix fictional feature film originals: an analysis of release strategies
Authors: Roig Antoni , Clares-Gavilán Judith , Sánchez-Navarro Jordi
Published: April 2021

This article offers an analysis of the strategies behind the release of original Netflix fictional feature films. Even if there is an already extensive literature about the streaming giant, little academic attention has been devoted to the release strategies of feature film originals and its implications for film production and distribution. With this goal in mind, we have built a database of titles identifiable as original Netflix features between 2015 and 2018 (n=171), considering theatrical exhibition, festival presence, language, genre, release territories and involvement in production. We have contrasted this macro-level approach with a more micro-level analysis through specific case-examples, in order to consider the case-by-case particularities of the film industry. Per our results, (a) Netflix has combined consistent release methods with some contingent experiments based on trial and error; (b) the unfolding of these strategies is related to the company’s transnational identity and to the (c) goal of recognition according to established quality standards, like top film festivals or prestigious awards. Furthermore, the observed tendency towards capillary collaboration with local agents points to more potential diversity of catalogue titles and in some cases a greater international exposure of non-English speaking titles, even if circumscribed to popular genres like science-fiction, thriller or horror.
An analysis of feminist graphics published on Instagram by Spanish female professionals on the subject of International Women’s Day (2019-2020)
Authors: Suárez-Carballo Fernando , Martín-Sanromán Juan-Ramón , Martins Nuno
Published: April 2021

The present scene, defined as it is by the undisputed prominence of imagery and the power of social media acting as tools for political activism and public interaction, is strongly influenced by Instagram. This is a platform with a predominantly graphic format where imagery, as a means of visual communication, acquires a special significance. In the 21st century, the term cyberfeminism has become synonymous with that part of feminist philosophy focusing on new technologies, the internet and the digital world generally. The present study analyses images created by Spanish professional female illustrators for International Women’s Day (March 8th), which were published on Instagram in 2019 and 2020. It will focus primarily on three kinds of imagery: plastic, linguistic and iconic. By mainly analyzing content and a sample of 124 artworks developed during this period, this study goes on to highlight the significance of the color violet. This is the plastic resource that stands out most from a very stylistically heterogeneous set of graphics. Complementing imagery is the important role of linguistics with frequent repetition of iconic references and a preference for representation of women. This last aspect is mainly with reference to their strength and security, in addition to an inclination for concepts linked to the need for vindication, sorority and empowerment.
Political critique in Madrid’s street art scene: from the late ‘90s until now
Authors: Gutiérrez-Colomer-Ruiz Natalia , Izquierdo-Expósito Violeta , Abejón-Mendoza Paloma
Published: April 2021

The aim of this paper is to explore the political messages painted on Madrid’s walls by urban artists from the beginning of this artistic and political movement (the end of the 1990s) to the present day. We developed an extensive field-work that has helped us to create the first compilation of the key political messages of urban art in Madrid, based on an exploratory research approach complemented by the use of social media search. This descriptive and documentary approach was followed while keeping in mind that a wall is a public channel open to all and an outstanding method for expressing any political opinion with the greatest amount of visibility. Over the time span analyzed, the investigation discovered 15 urban artists with political content in their artistic production. The findings indicate that the political theme of these artists’ works focuses primarily on condemning the Spanish government for current issues such as corruption or the economic crisis, as well as past events such as the Iraq War. Other recurring themes include social criticism of municipal policies and the living conditions of underprivileged groups such as refugees and beggars, as well as support for feminism and critiques of the rapid gentrification process of certain historic Madrid neighborhoods, such as Malasaña and Lavapiés.
Parodic satire of NO-DO in «Polònia»: Iconoclasm and visual re-framing of the Spanish (far)right-wing discourse
Authors: Valhondo José-Luis
Published: April 2021

As cultural content, Polònia constitutes an unusual case. We are dealing with one of the highest audience-share television programmes in Catalonia in recent years. Moreover, it is uncommon in the Spanish political-media system, where satire does not enjoy such a social acceptance by audiences. The purpose of this study consists of analysing how a parody of a Francoist regime newsreel (NO-DO) serves the purpose of ridiculing and satirising the extreme-rightist discourse of Vox political party. We employ a visual re-framing approach to the topic, examining keyframes of three Polònia pieces related to the formation of the leftist coalition government between the Socialist Party and Unidas Podemos, the dialogue roundtable about the Catalan political conflict and the feminist celebration of the International Women’s Day. The results refer to the re-articulation of the representation of power icons in the Catalan political sphere. Polònia mocks an alleged victimisation of the rightist discourse concerning the Catalan conflict, feminism and immigration. Those topics resonate in the old Francoist discourse of NO-DO. We relate those results to the building of national identities amid a political conflict, in the sense of how Polònia addressed a specific target with cultural and political cues. At the same time, the parodic satire of TV3 Polònia is considered in the context of (post)modern iconoclastic tradition.
Formation of a fused image of the land surface based on pixel clustering of location images in a multi-position onboard system
Authors: Nenashev Vadim , Khanykov Igor
Published: April 2021

The paper proposes a method for fusioning multi-angle images implementing the algorithm for quasi-optimal clustering of pixels to the original images of the land surface. The original multi-angle images formed by the onboard equipment of multi-positional location systems are docked into a single composite image and, using a high-speed algorithm for quasi-optimal pixel clustering, are reduced to several colors while maintaining characteristic boundaries. A feature of the algorithm of quasi-optimal pixel clustering is the generation of a series of partitions with gradually increasing detail due to a variable number of clusters. This feature allows you to choose an appropriate partition of a pair of docked images from the generated series. The search for reference points of the isolated contours is performed on a pair of images from the selected partition of the docked image. A functional transformation is determined for these points. And after it has been applied to the original images, the degree of correlation of the fused image is estimated. Both the position of the reference points of the contour and the desired functional transformation itself are refined until the evaluation of the fusion quality is acceptable. The type of functional transformation is selected according to the images reduced in color, which later is applied to the original images. This process is repeated for clustered images with greater detail in the event that the assessment of the fusion quality is not acceptable. The purpose of present study is to develop a method that allows synthesizing fused image of the land surface from heteromorphic and heterogeneous images. The paper presents the following features of the fusing method. The first feature is the processing of a single composite image from a pair of docked source images by the pixel clustering algorithm, what makes it possible to isolate the same areas in its different parts in a similar way. The second feature consists in determining the functional transformation by the isolated reference points of the contour on the processed pair of clustered images, which is later applied to the original images to combine them. The paper presents the results on the synthesis of a fused image both from homogeneous (optical) images and from heterogeneous (radar and optical) images. A distinctive feature of the developed method is to improve the quality of synthesis, increase the accuracy and information content of the final fused image of the land surface.
Periodogram estimating the spectral power density based upon signals’ binary-sign stochastic quantization using window functions
Authors: Yakimov Vladimir
Published: April 2021

Spectral analysis of signals is used as one of the main methods for studying systems and objects of various physical natures. Under conditions of a priori statistical uncertainty, the signals are subject to random changes and noise. Spectral analysis of such signals involves the estimation of the power spectral density (PSD). One of the classical methods for estimating PSD is the periodogram method. The algorithms that implement this method in digital form are based on the discrete Fourier transform. Digital multiplication operations are mass operations in these algorithms. The use of window functions leads to an increase in the number of these operations. Multiplication operations are among the most time consuming operations. They are the dominant factor in determining the computational capabilities of an algorithm and determine its multiplicative complexity. The paper deals with the problem of reducing the multiplicative complexity of calculating the periodogram estimate of the PSD using window functions. The problem is solved based on the use of binary-sign stochastic quantization for converting a signal into digital form. This two-level signal quantization is carried out without systematic error. Based on the theory of discrete-event modeling, the result of a binary-sign stochastic quantization in time is considered as a chronological sequence of significant events determined by the change in its values. The use of a discrete-event model for the result of binary-sign stochastic quantization provided an analytical calculation of integration operations during the transition from the analog form of the periodogram estimation of the SPM to the mathematical procedures for calculating it in discrete form. These procedures became the basis for the development of a digital algorithm. The main computational operations of the algorithm are addition and subtraction arithmetic operations. Reducing the number of multiplication operations decreases the overall computational complexity of the PSD estimation. Numerical experiments were carried out to study the algorithm operation. They were carried out on the basis of simulation modeling of the discrete-event procedure of binary-sign stochastic quantization. The results of calculating the PSD estimates are presented using a number of the most famous window functions as an example. The results obtained indicate that the use of the developed algorithm allows calculating periodogram estimates of PSD with high accuracy and frequency resolution in the presence of additive white noise at a low signal-to-noise ratio. The practical implementation of the algorithm is carried out in the form of a functionally independent software module. This module can be used as a part of complex metrologically significant software for operational analysis of the frequency composition of complex signals.
Hybrid method of conventional neural network training
Authors: Golubinskiy Andrey , Tolstykh Andrey
Published: April 2021

The paper proposes a hybrid method for training convolutional neural networks. The method consists of combining second and first-order methods for different elements of the architecture of a convolutional neural network. The hybrid convolution neural network training method allows to achieve significantly better convergence compared to Adam; however, it requires fewer computational operations to implement. Using the proposed method, it is possible to train networks on which learning paralysis occurs when using first-order methods. Moreover, the proposed method could adjust its computational complexity to the hardware on which the computation is performed; at the same time, the hybrid method allows using the mini-packet learning approach. The analysis of the ratio of computations between convolutional neural networks and fully connected artificial neural networks is presented. The mathematical apparatus of error optimization of artificial neural networks is considered, including the method of backpropagation of the error, the Levenberg-Marquardt algorithm. The main limitations of these methods that arise when training a convolutional neural network are analyzed. The analysis of the stability of the proposed method when the initialization parameters are changed. The results of the applicability of the method in various problems are presented.
Obtaining tissues and organs for transplantation and coronavirus infections: a scoping review
Authors: Pessoa João Luís Erbs , Knihs Neide da Silva , Magalhães Aline Lima Pestana , Paim Sibele Maria Schuantes , Wachholz Laísa Fischer , Roza Bartira de Aguiar
Published: April 2021

ABSTRACT Objectives: to map the care recommendations available in the literature capable of supporting health professionals’ decision-making in the organ and tissue donation process before the COVID-19 pandemic. Methods: is a nine-step scoping review with searches performed in three databases and an electronic library (Science Direct). Results: 873 publications were retrieved, 15 selected for analysis. All were published in 2020, originating mainly on China, with predominance of original articles. The most frequent recommendations relate to testing to detect SARS-CoV-2 infection for deceased donors (52.6%) and clinical evaluation of potential donors and possible donors (31.6%). Final considerations: it is believed that the recommendations evidenced will support health professionals in the process of donation and organ transplantations to determine interventions for decision-making during the COVID-19 pandemic.