bluuebunny/crossref_metadata_2025 huggingface dataset:
ПРОБЛЕМЫ ОКАЗАНИЯ БЕСПЛАТНОЙ
ЮРИДИЧЕСКОЙ ПОМОЩИ В РОССИЙСКОЙ ФЕДЕРАЦИИ
Authors: Кузьмин А. Е. , Милованова Н. А.
Published: August 2023

В настоящей статье рассматриваются правовые основы оказания бесплатной юри-дической помощи в Российской Федерации. Раскрываются основные цели оказания бесплатной юридической помощи. Анализируются теоретические и практические про-блемы реализации права на получение квалифицированной юридической помощи бесплатно.
ПРАВО РЕБЁНКА НА ОБРАЗОВАНИЕ И ГАРАНТИИ
ЕГО ОБЕСПЕЧЕНИЯ В РОССИЙСКОЙ ФЕДЕРАЦИИ
Authors: Певцова И. Е. , Алиева Д. Р.
Published: August 2023

В статье рассматривается вопрос о праве ребенка на образование, раскрываются гарантии получения основного общего образования. Подчеркивается важность между-народных правовых актов, в которых право на образование рассматривается как одно из фундаментальных и неотъемлемых прав человека. Раскрывается нормативное со-держание права на образование.
ANALYZING LAND USE TYPES’ EFFECTS ON LST USING THE GWR MODEL AND CASE STUDIES IN BEIJING
Authors: Yao Zigang , Liu Liyan , Li Wenmo , Shahraki Abdol Aziz , Pang Yan
Published: August 2023

The development of urbanization and the transformation of green lands into impermeable land increase temperature and create urban heat islands (UHIs). Our observations with remote sensing instruments of Landsat platforms show considerable changes in land use types in Beijing city with the shrinking of green lands, expansion of built environments, and a slight increase in the temperature during the recent four decades. Using remote sensing instruments of Landsat platforms and registered data from two meteorological stations in Beijing, this study finds the relationship between land surface temperature (LST) and the increasing conversion of cultivated lands into built-up areas. This article presents innovative research that shows the mutual correlation well and recommends revisions in the land use policies for better weather. The geographically weighted regression model (GWR) with a Gaussian weighting kernel function analyzes the impact of various urban land use types on the LST and the increase UHIs. In Beijing city, green lands show fewer standard deviations (SD) in the average temperatures equal to 0.109, while the industrial spaces exhibit a high SD equal to 0.212. The outcomes of this paper contribute to finding optimal land use policies everywhere in the world with the increasing urbanization through simulating its model for a more comfortable life.
Broadband VLA Spectral-line Survey of a Sample of Ionized Jet Candidates
Authors: Sanchez-Tovar E. , Araya E. D. , Rosero V. , Hofner P. , Kurtz S.
Published: August 2023

The study of the interaction between ionized jets, molecular outflows, and their environments is critical to understanding high-mass star formation, especially because jets and outflows are thought to be key in the transfer of angular momentum outward from accretion disks. We report a low spectral resolution Karl G. Jansky Very Large Array (VLA) survey for OH, NH3, CH3OH, and hydrogen radio recombination lines, toward a sample of 58 high-mass star-forming regions that contain numerous ionized jet candidates. The observations are from a survey designed to detect radio continuum; the novel aspect of this work is to search for spectral lines in broadband VLA data (we provide the script developed in this work to facilitate exploration of other data sets). We report detection of 25 GHz CH3OH transitions toward 10 sources; 5 of them also show NH3 emission. We found that most of the sources detected in CH3OH and NH3 have been classified as ionized jets or jet candidates and that the emission lines are coincident with, or very near (≲0.1 pc), these sources; hence, these molecular lines could be used as probes of the environment near the launching site of jets/outflows. No radio recombination lines were detected, but we found that the rms noise of stacked spectra decreases following the radiometer equation. Therefore, detecting radio recombination lines in a sample of brighter free–free continuum sources should be possible. This work demonstrates the potential of broadband VLA continuum observations as low resolution spectral-line scans.
Orbital Decay in an Accreting and Eclipsing 13.7 Minute Orbital Period Binary with a Luminous Donor
Authors: Burdge Kevin B. , El-Badry Kareem , Rappaport Saul , Sunny Wong Tin Long , Bauer Evan B. , Bildsten Lars , Caiazzo Ilaria , Chakrabarty Deepto , Chickles Emma , Graham Matthew J. , Kara Erin , Kulkarni S. R. , Marsh Thomas R. , Nynka Melania , Prince Thomas A. , Simcoe Robert A. , van Roestel Jan , Vanderbosch Zach , Bellm Eric C. , Dekany Richard G. , Drake Andrew J. , Helou George , Masci Frank J. , Milburn Jennifer , Riddle Reed , Rusholme Ben , Smith Roger
Published: August 2023

We report the discovery of ZTF J0127+5258, a compact mass-transferring binary with an orbital period of 13.7 minutes. The system contains a white dwarf accretor, which likely originated as a post–common envelope carbon–oxygen (CO) white dwarf, and a warm donor (T
eff,donor = 16,400 ± 1000 K). The donor probably formed during a common envelope phase between the CO white dwarf and an evolving giant that left behind a helium star or white dwarf in a close orbit with the CO white dwarf. We measure gravitational wave–driven orbital inspiral with ∼51σ significance, which yields a joint constraint on the component masses and mass transfer rate. While the accretion disk in the system is dominated by ionized helium emission, the donor exhibits a mixture of hydrogen and helium absorption lines. Phase-resolved spectroscopy yields a donor radial velocity semiamplitude of 771 ± 27 km s−1, and high-speed photometry reveals that the system is eclipsing. We detect a Chandra X-ray counterpart with L
X ∼ 3 × 1031 erg s−1. Depending on the mass transfer rate, the system will likely either evolve into a stably mass-transferring helium cataclysmic variable, merge to become an R CrB star, or explode as a Type Ia supernova in the next million years. We predict that the Laser Space Interferometer Antenna (LISA) will detect the source with a signal-to-noise ratio of 24 ± 6 after 4 yr of observations. The system is the first LISA-loud mass-transferring binary with an intrinsically luminous donor, a class of sources that provide the opportunity to leverage the synergy between optical and infrared time domain surveys, X-ray facilities, and gravitational-wave observatories to probe general relativity, accretion physics, and binary evolution.
Constraining Dark Energy from the Local Group Dynamics
Authors: Benisty David , Davis Anne-Christine , Evans N. Wyn
Published: August 2023

This Letter develops a method to constrain the cosmological constant Λ from binary galaxies, focusing on the Milky Way and Andromeda galaxies. We provide an analytical solution to the two-body problem with Λ and show that the ratio between the Keplerian period and

T

Λ

=
2
π

/

(
c

Λ

)
≈
63.2

Gyr

controls the importance of effects from the cosmological constant. The Andromeda–Milky Way orbit has a period of ∼17 Gyr, and so dark energy has to be taken into account. Using the current best mass estimates of the Milky Way and Andromeda galaxies, we find the cosmological constant value has an upper bound that is 5.44 times the value obtained by Planck. With future astrometric measurements, the bound on the cosmological constant can be reduced to

1.67
±
0.79

Λ

PL

. Our results offer the prospects of constraints on Λ over very different scales than previously. The Local Group provides also a completely novel platform to test alternative theories of gravity. We illustrate this by deriving bounds on scalar-tensor theories of gravity over megaparsec scales.
First insights into diversity and potential metabolic pathways of bacterial and fungal communities in the rhizosphere of Argemone mexicana L. (Papaveraceae) from the water-level-fluctuation zone of Wudongde Reservoir of the upper Yangtze river, China
Authors: Zhou Lanfang , Wu Shengjun , Ma Maohua
Published: August 2023

The water-level fluctuation zone (WLFZ) of Wudongde reservoir of the upper Yangtze river is a completely new aquatic-terrestrial transitional zone, and its plant degenerate issue is attracting global concerns. Uncovering the unknown rhizosphere microbiome of dominant plants of this zone is helpful in understanding the plant-microbe interactions and their growth under the largely varying environment. Here, a first exploration of the rhizosphere bacterial and fungal communities of wilted (JB) and unwilted (JA) Argemone mexicana L. individuals from the WLFZ of Wudongde reservoir was carried out using high-throughput sequencing and MetaCyc metabolic pathway analyses. The results showed that rhizosphere of wilted A. mexicana L individuals exhibited a higher microbial richness and diversity than the unwilted ones, irrespective of the bacterial and fungal communities. It was noted that 837 common bacterial amplicon sequence variants (ASV) and 92 common fungal ASV were presented in both JA and JB with 3108 bacteria and 212 fungi unique to JA, and 3569 bacteria and 693 fungi unique to JB. Linear discriminant analysis effect Size (LEfSe) analyses indicated that the taxa that had the most contribution to observed differences between both JA and JB was Proteobacteria, Actinobacteria and Ascomycota for JA, and Bacteroidetes, Firmicutes, Verrucomicrobia, Basidiomycota and Ascomycota for JB. Organic compound conversion pathway (degradation/reduction/oxidation) was consistently highly represented in the rhizosphere microbiomes of both JA and JB. Overall, this study provides insights into the rhizosphere microbiome composition, diversity and metabolic pathways of both wilted and unwilted A. mexicana L. individuals in the WLFZ of Wudongde reservoir, and the results give valuable clues for manipulating microbes to support plant growth in such a recently-formed WLFZ under a dry-hot valley environment.
A two-strain model of infectious disease spread with asymmetric temporary immunity periods and partial cross-immunity
Authors: Johnston Matthew D. , Pell Bruce , Rubel David A.
Published: August 2023

We introduce a two-strain model with asymmetric temporary immunity periods and partial cross-immunity. We derive explicit conditions for competitive exclusion and coexistence of the strains depending on the strain-specific basic reproduction numbers, temporary immunity periods, and degree of cross-immunity. The results of our bifurcation analysis suggest that, even when two strains share similar basic reproduction numbers and other epidemiological parameters, a disparity in temporary immunity periods and partial or complete cross-immunity can provide a significant competitive advantage. To analyze the dynamics, we introduce a quasi-steady state reduced model which assumes the original strain remains at its endemic steady state. We completely analyze the resulting reduced planar hybrid switching system using linear stability analysis, planar phase-plane analysis, and the Bendixson-Dulac criterion. We validate both the full and reduced models with COVID-19 incidence data, focusing on the Delta (B.1.617.2), Omicron (B.1.1.529), and Kraken (XBB.1.5) variants. These numerical studies suggest that, while early novel strains of COVID-19 had a tendency toward dramatic takeovers and extinction of ancestral strains, more recent strains have the capacity for co-existence.
Quantification de l’érosion hydrique en nappe dans la moyenne vallée de l’Oued Sarrath (Haut-Tell, Tunisie)
Authors: Aissaoui Chérifa , Ghazi Abdelhamid Ben
Published: August 2023

Cette étude présente les résultats obtenus du travail de cartographie thématique des facteurs d’érosion diffuse dans le bassin de la retenue du barrage de l’Oued Sarrath. Elle s’appuie sur l’application de la version révisée du modèle empirique de Wischmeier et Smith 1978 (USLE) et propose sa cartographie. Pour la détermination des pertes en terres et l’élaboration de la carte de sensibilité à cette érosion, le modèle a nécessité le croisement des paramètres liés aux précipitations, à la structure et texture des sols, à la pente, au couvert végétal et aux techniques antiérosives. Les résultats obtenus montrent que la perte moyenne des sols, liée à l’érosion hydrique en nappe dans le bassin de la retenue du barrage de l’Oued Sarrath, est de l’ordre de 23,72 tonnes par hectare par an. Une quantité qui dépasse les taux tolérables dans des conditions similaires. Les pertes en sol sont par ailleurs inégalement réparties. Elles sont très faibles dans les bas-fonds, et atteignent 458,945 tonnes par hectare par an au niveau des reliefs pentus, dépourvus de moyens de protection antiérosive.
Exploring the Potential of ChatGPT in Financial Decision Making
Authors: Ahangar Reza Gharoie , Fietko Agata
Published: August 2023

This chapter investigates the potential role of OpenAI's ChatGPT in investments to assess its proposed solutions' accuracy, potential benefits and drawbacks, and implications for financial decisions. The study utilizes empirical examples to evaluate ChatGPT's performance in providing financial advice. The results indicate that while ChatGPT can define financial terms and explain them in detail, it cannot provide investment suggestions. Moreover, the analysis suggests that the ChatGPT can provide more accurate information when users break down their questions into more specific topics. The study also highlights the need for more comprehensive training data to allow ChatGPT to provide more accurate advice. In addition, the research advises investors to be aware of ChatGPT's limitations and recommends breaking down financial questions into more specific topics to maximize the benefits of this technology. It is concluded that ChatGPT can be a helpful resource for financial experts but not for those with limited financial expertise and knowledge.
Fixed Point Theory and Insurance Loss Modeling
Authors: Sakib S M Nazmuz
Published: August 2023

This study focuses on the future development of an insurance company during difficult circumstances, which can be described by a stochastic process that must be effectively managed to achieve the best goals for the company. Effective risk or loss management models can bring in more revenue for the insurer and result in less conditional pay-out of claims to the insured. While insurance losses, risks, and premium calculation are important topics in the field, existing literature has not always stood the test of time due to the dynamic nature of insurance principles and practices. There is a need for a suitable loss model that can adjust loss rating to a particular experience and provide an appropriate and equitable premium. The aim of this research is to find sufficient conditions for the convergence of an algorithm towards a fixed point under typical insurance loss and actuarial circumstances, resulting in a uniquely determined solution. The study presents a unique fixed point, which the algorithm converges towards through straightforward and simplified generalised formulae and functions.
Laboratory Geotechnical Investigations on Five Silty Soils Sampled along the Banks of the Lubumbashi River/Haut-Katanga/DR Congo
Authors: Kiyukeno Yannick , Mukoko Gustave , François Bertrand
Published: August 2023

An adequate design of port structures along waterways requires a good knowledge of the geotechnical properties of the surrounding soils. This study aims to characterize the geotechnical laboratory properties of alluvial soils along the Lubumbashi river (section between the Tshombe and Tshondo bridges, approximately 3 km long) in the city of Lubumbashi, province of Haut Katanga in DR Congo. To meet this objective, five sampling zones were selected from which samples were taken with a hand auger and various geotechnical laboratory tests were performed. Identification tests reveal that the tested soils have low to moderate plasticity and are in the range of sandy silt to silty sand with a low fraction of clay particles, essentially inactive. Oedometric compression tests reveal that the soils in place are (moderately) compressible. The consolidated undrained (CU) triaxial compression and direct shear tests indicate effective values of internal friction angle and negligible drained cohesion that, are consistent for this kind of soil. In the end, the compressibility and strength parameters of the five tested soils are correlated with their plasticity index, showing a decrease in the shear strength and an increase in the compressibility when the plasticity index increase.
Performance Evaluation of Hydroponics Control Systems for pH, Temperature, and Water Level Control
Authors: Rathedi Maemo , Matsebe Oduetse , Ditshego Nonofo M.J.
Published: August 2023

This study evaluates different control algorithms used in a hydroponic farming system to improve the quality of farm produce and resource efficiency. It focuses on three key hydroponic control parameters(potential hydrogen (pH), water level, and temperature control). Mathematical models are derived from the literature to represent hydroponic environments. These models are used for simulation purposes in MATLAB software to implement various control algorithms to evaluate their performance against each other and the system requirements utilizing transient performance parameters. Transient performance parameters are overshoot, settling time, rise time ,and steady-state error. The various control algorithms are fuzzy logic (FL), Proportional Integral Derivative (PID), and Proportional Integral Derivative-Fuzzy logic controller (PID-FL). This paper examines the performance of the hybrid PID-FL controllers compared to the most commonly used fuzzy logic and PID controllers. The result of the work shows that PID-FL is generally better for all the system models, making it more applicable.
Promoting Food Tourism Through Digital Media With Special Reference To Sri Lanka As A Tourist Destination
Authors: Dawson S. L. , Sarachchandra K. S. H. , Kannangara S. D. P. P.
Published: August 2023

Many travellers recognize food experiences as a must-do activity at travel destinations as much as the interest shown by them, Destination Management Organizations around the world have identified food as a part of special interest tourism and an experience that helps differentiate a destination’s offerings against competitors. The current study set out to explore whether travellers perceive food as a travel attraction that motivates them to travel to a destination and whether food can provide a memorable experience to such travellers and how well destination management organizations promote food tourism through digital media in a setting where many travellers search for information online. The study included a preliminary study in which the opinions of travellers were identified through a content analysis of experiences shared on online travel review sites and social media. Thestudy conducted a qualitative research approach where interviews were conducted to gain further insights into travellers’ food experiences. Further, the effectiveness of promoting food tourism through digital media by destination management organizations was analyzed through a content analysis of textual and visual content on websites. The findings of the study indicate that travellers consider food as a major motive to travel, as an experience booster, a novel and exciting experience, an experience beyond just eating, an aid to learning about locals’ lifestyle, an experience worth recreating and an experience that results in a change in lifestyle becoming a peak touristic experience. It was apparent that Local Destination Management Organizations do not effectively communicate these factors about food experiences through their digital platforms. This study is significant in a theoretical aspect as it presents seven characteristics of food experiences concerning the conceptual model of tourist experience and for applying this model to the digital context taking the destination management organization’s point of view. It is also significant in a practical aspect as it shows the potential of food to be a main attraction for Sri Lanka Tourism and portrays space for improvement in marketing such experiences,especially in digital media.
Experimental study on stabilometric complex for terrainkur in overweight people
Authors: Fesyun Anatoliy D. , Grishechkina Irina A. , Lobanov Andrey A. , Andronov Sergei V. , Popov Andrey I. , Eremushkin Michail A. , Terentev Kirill V. , Bogdanov Rinat R. , Sanina Natalia P. , Reverchuk Igor V.
Published: August 2023

Overweight and obesity is a multifactorial, multisystem disease declared a global epidemic by the World Health Organization (WHO) as early as in 1997. At least 30% of the working-age population in Russia is overweight. Only the use of physical activity as an integral (basic) part of obesity treatment and maintenance of the body weight achieved in the course of treatment can achieve durable and long-lasting treatment results as well as significant changes in the body structure (fat/non-fat body weight ratio). Terrainkur (therapeutic walking) is a method of spa treatment that combines climatotherapy and physical therapy. One of the problems in physical activity in obese people is the difficulty they experience in exercising due to the impaired walking pattern caused by imbalances in the muscle chains, including pelvic region, cervical region, which reduces endurance and commitment to physical activity. The study found that the exposure group (Terrainkur) showed lower values of "total fat", "metabolic age", "basic caloric value" compared to initial results and the control group; the exposure group (Terrainkur) showed a decrease in the deviation of the centre of body axis projection from the proper axis, the percentage of non-compliance with the proper fluctuations of the foot underextension. These changes contributed to the elimination of terrainkur restrictions and, as a result, improved the patient compliance during the terrainkur exercises.
Killer cell immunoglobulin-like receptor alleles influence susceptibility to occult hepatitis B infection in West African population
Authors: Bazie Momeiyi M. , Djigma Florencia W. , Sanou Mahamoudou , Sorgho Pegdwendé A. , Ouattara Abdoul K. , Obiri-Yeboah Dorcas , Kapieko Nadege , Sombie Herman K. , Bado Prosper , Yelemkoure Edwige T. , Kiendrebeogo Isabelle T. , Nagalo Marius B. , Yonli Albert T. , Simpore Jacques
Published: August 2023

Occult hepatitis B infection (OBI) is a public health problem in Burkina Faso. OBI represents a risk factor for the development of cirrhosis and hepatocellular carcinoma (HCC). OBI could be due to mutant viruses undetectable by HBsAg assays or a strong suppression of viral replication and gene expression under the pression of the host immune system. To investigate the role of killer cell immunoglobulin‑like receptor (KIR) gene polymorphisms in patients with OBI in Burkina Faso compared to healthy and chronic hepatitis B subjects. A total of 286 participants was recruited, including 42 cases of OBI, 110 cases of chronic hepatitis B and 134 HBV negative subjects. SSP‑PCR was performed to search for the presence of KIR genes. The HBV viral load was determined by qPCR. The frequencies of the activator gene KIR2DS5 (P=0.045) and the pseudogene KIR2DP1 (P0.001) in patients with OBI were higher than those in patients with chronic hepatitis B. These genes are associated with susceptibility of occult hepatitis B infection. The frequencies of the inhibitory KIR gene KIR2DL3 (P=0.01) of patients with occult hepatitis B were lower than those in chronic hepatitis B patients. This gene KIR2DL3 is associated with protection against occult hepatitis B infection. Also, the frequencies of the inhibitory KIR genes KIR2DL2 (P0.001), KIR2DL3 (P0.001) and activators KIR2DS2 (P0.001) in chronic hepatitis B patients were higher compared to the frequencies of the KIR genes in healthy subjects. These genes KIR2DL3, KIR2DL5 (A, B), KIR3DL3, KIR3DS1, KIR2DL2 and KIR2DS2 are thought to be genes associated with the susceptibility to OBI. The KIR2DS5 and KIR2DP1 genes could be associated with susceptibility to OBI. As for the KIR gene KIR2DL3 could be associated with protection against occult hepatitis B infection.
A Comparison of Skin Graft Techniques with and without Plaster Back Slab Dressing in Reducing Donor Site Morbidity in Radial Forearm Free Flap Surgery - A Retrospective Study
Authors: Lakshmiah Sundarraj , Ko Yuiyin , Mair Manish , Baker Andrew , Ameerally Phillip
Published: August 2023

Introduction:

The radial forearm free flap (RFFF) is a commonly used free flap for the reconstruction of orofacial defects because of its versatility and reliability. The donor site is closed with either split or full-thickness skin graft, and one of the common donor site morbidities is skin graft failure. Various techniques to minimise skin graft failure were reported, and we compared the skin graft techniques with and without plaster back slab dressing in the radial forearm donor site.

Materials and Methods:

This is a retrospective study of 75 patients who had RFFF for reconstruction of oral cavity cancer at two different tertiary teaching hospitals in the United Kingdom between April 2015 and March 2020. Thirty-nine patients from Hospital one had volar back slap, bolster dressing and crepe bandage. In contrast, 36 patients from Hospital two had only pressure dressing without a back slab.

Results:

The mean age of the study population was 60.65 (P = 0.274). In both groups, two patients had donor site complications. However, there was no significant difference in the donor site skin graft complications with a P = 0.662.

Discussion:

There was no evidence in the literature to support an ideal bandage for skin graft at the RFFF donor site. Our comparison of two techniques of skin graft dressings with and without back slap did not show any difference in the skin graft take, and the volar back slab did not add any additional benefits. The simple use of foam as a bolster dressing without a back slab is ideal for the radial forearm free flap donor site.
Fresh-Frozen Plasma as a Low-Cost Replacement of Intravenous Immunoglobulin for the Treatment of Symptomatic Hypogammaglobulinemia
Authors: Kumar Pankaj , Singh Thakur Prashant , Aggarwal Amita , Rai Praveer , Goel Amit
Published: August 2023

Hypogammaglobulinemia commonly presents with chronic diarrhea. Unfortunately, these patients require intravenous immunoglobulin (IVIG) transfusions of 400–800 mg/kg every 3–4 weeks as a standard treatment for hypogammaglobulinemia. Repeated transfusion of IVIG is costly, and many patients may not be able to afford it. We report the case of a young male with chronic small intestinal diarrhea who was later diagnosed with hypogammaglobulinemia. We treated the patient with fresh-frozen plasma (FFP) and the patient responded favorably. FFP transfusion may be an affordable alternative to IVIG in the treatment of hypogammaglobulinemia.
Nebivolol and Atenolol Roles in Doxorubicin-Induced Cardiotoxicity
Authors: Issa Hajer Kays , Al-Gareeb Ali Ismail
Published: August 2023

Background:

This study investigated the potential role of ivabradine (Nebivolol and Atenolol) in the attenuation of doxorubicin induced cardiotoxicity in mice. So we will seek the role of nebivolol and atenolol in reducing cardiotoxicity induced by doxorubicin in this experimental study.

Aims:

To investigate the potential roles of nebivolol and atenolol in the attenuation of doxorubicin (DXR)-induced cardiotoxicity in mice.

Materials and Methods:

A total of 42 Swiss-Albino male and female mice were used, which were divided into six equal groups: A negative control, a group 1 not received any agents, group 2 (DXR group) received a single dose of DXR 15 mg/kg, treated group 3 was pretreated with nebivolol 15 mg/kg plus DXR. Treated group 4 was pretreated with nebivolol 30 mg/kg plus DXR. Treated group 5 was pretreated with Atenolol 45 mg/kg plus DXR, and treated group 6 was pretreated with atenolol 90 mg/kg plus DXR. The duration of the study was 10 days. Inflammatory biomarkers including tumor necrosis factor-alpha (TNF-α), lactate dehydrogenase (LDH), malondialdehyde (MDA), and cardiac troponin (cTn-I) serum levels were measured. SPSS version 28.00 was used for data analysis.

Results:

TNF-α, LDH, MDA, and cTn-I serum levels were higher in the DXR-treated mice as compared to the control (P < 0.05). Nebivolol and atenolol produced a dose-dependent effect in the reduction of TNF-α, LDH, MDA, and cTn-I serum levels as compared to the DXR-treated mice (P < 0.05).

Conclusion:

Atenolol and nebivolol were effective agents in the mitigation of DXR-induced cardiotoxicity by their anti-inflammatory effects of both atenolol and nebivolol and antioxidant effects of nebivolol. Atenolol and nebivolol illustrated a dose-dependent effect in the attenuation of DXR-induced cardiotoxicity through inhibition of lipid peroxidation and cardiomyocyte injury.
Correlation of NF-kB Serum Level with the Expression Pattern of Microrna-221 in a Sample of Hcv-Exposed Iraqi Patients
Authors: Al-Salihy Shaimaa Rahem , Al-Shawk Refif , Al-Waysi Safaa Abdul-Karim , Rasheed Maarib Nazih
Published: August 2023

Background:

Hepatitis C virus (HCV) has the ability to change cellular messenger RNA transcription and translation by stimulating the synthesis of cellular microRNAs (miRNAs) that impair immune response and facilitate viral reproduction. One of the most important members of the immune response against HCV is nuclear factor-kappa B (NF-κB), which is regulated by cellular miRNAs.

Aims:

we aimed to investigate the correlation of NF-κB serum level with circulatory miRNA-221 (miR-221) fold change in HCV-exposed individuals.

Materials and Methods:

Serum level of NF-κB in 88 samples (22 patients with persistent HCV infection, 22 individuals with spontaneous HCV virus clearance, 22 individuals treated with direct-acting antivirals (DAAs) drugs, and 22 uninfected apparently healthy blood donors as control) was measured by enzyme-linked immunosorbent assay. Reverse transcriptase–polymerase chain reaction was used to quantify the expression fold of circulatory miR-221.

Results:

The results showed that there was a significant decrease in the mean level of NF-κB at P < 0.000 among HCV-exposed patients (2.0058 ng/ml) as compared to the control group (2.9841 ng/ml). The mean fold change of miR-221 was significantly upregulated about six more times among HCV-exposed patients (mean = 6.3545) compared to the control group (mean = 1.1864). Furthermore, the mean ± standard deviation of miR-221 fold change in patients with persistent HCV infection was significantly higher compared to patients cured after DAA therapy (P = 0.048), there was a weak negative correlation (r = −0.246, P = 0.021) between NF-κB serum level and miR-221 folding level.

Conclusion:

HCV infection disrupts NF-κB activation, resulting in dysregulation of miR-221 that persists long after the virus has been cleared. Thus, quantification of serum NF-κB and miR-221in HCV-exposed patients could be used as noninvasive prognostic marker during long-term follow-up. Furthermore, a miRNAs profile analysis can help distinguish HCV-exposed from healthy individuals.
Morphometric Measurements of Carrying Angle of the Elbow among Sample of Iraqi Medical Students: An Observational, Cross-Sectional Study
Authors: Assi Mohammed Hussein
Published: August 2023

Background:

The carrying angle (CA) is an acute angle occurring between the longitudinal axis of the upper arm and that of the extended and supinated forearm. CA allows swinging of the upper limb without hitting the pelvis. It appears to be larger in females than in males and also shows some variation to anthropometric parameters. Knowledge of CAs is valuable for orthopedic surgeons and biomedical engineers as well as for forensic specialists and anthropologists.

Aims:

The aim of the study is to evaluate the normal range of CA among Iraqi population.

Materials and Methods:

The CAs of the right and the left upper limbs was measured by a clinical goniometer in 200 medical students. Analysis for differences was performed according to gender, laterality, height, weight, and hip circumference (HC).

Results:

The mean right CA in men was 9° and in women was 10.75°, while the mean left CA was 8.76° in men and 10.51° in women. The mean CA in females is significantly larger than in males. The mean CA of the right elbow was greater than that of the left. The mean CA shows a positive correlation with the individual height, weight, and HC.

Conclusion:

The study fortifies the knowledge of the standard range of CA of the elbow in a study population of apparently healthy Iraqi medical students and tries to make a reference value to be used for orthopedic surgeons, biomedical engineers as well as for forensic specialists and anthropologists.
Evaluation of Protective Effect of Metformin in Rats with Experimental Osteoarthritis
Authors: Al-Buhadily Ali K. , Al-Uqabi Rabab Utba , Al-Gareeb Ali I.
Published: August 2023

Objective:

The objective of this study is to evaluate metformin proposed protective effect against the development of osteoarthritis (OA) in rats.

Materials and Methods:

A total of 40 male Sprague–Dawley rats were included, divided into four groups: negative control (n = 10), positive control (OA induced by monoiodoacetate [MIA]) (n = 10), metformin 200mg/kg group (n = 10) preinduction of OA, and metformin 200 mg/kg group (n = 10) postinduction of OA. Serum C-telopeptide type II collagen (CTX-II), inflammatory biomarkers were evaluated for each group. For data analysis, SPSS version 26.00 was used.

Results:

Metformin-treated groups showed a significant reduction in inflammatory biomarkers and CTX-II serum levels compared with OA group (P < 0.05). Pretreatment with 200 mg/kg metformin imparted extra cartilage protective effect and further decreased inflammatory cytokines compared to posttreated (P < 0.05).

Conclusion:

Metformin produced a beneficial protective effect in experimental OA in rats. It attenuates the inflammatory reactions progression by preventing the release of pro-inflammatory cytokines in rats with experimental OA. Furthermore, metformin reduced cartilage degradation evidenced by lowering CTX-II serum levels experimental OA in rats.
Seroprevalence of Helicobacter pylori Infection in Tripoli, Libya
Authors: Atia Ahmed , Abuagela Manal , Abdulwahed Eman , Jerbi Rehab , Alwaseea Najia , Ahmed Fawzia , Alaqeli Eman , Ashur Abir Ben , El Magrahi Hamida , Mousa Arij
Published: August 2023

Background:

Infection with Helicobacter pylori is typically contracted in early childhood and is associated with a variety of upper gastrointestinal disorders. There is still little local information available on infection epidemiology. This study was performed to determine the antibodies of seroprevalence of H. pylori in people, with their relation to age and gender.

Methods:

A retrospective epidemiologic survey was conducted in different polyclinics in Tripoli from January 2021 to December 2021 to determine the seroprevalence of H. pylori infection. A total of 707 participants (452 males and 255 females, with mean age of 39 ± 19.3 years) were included in this study. For the detection of H. pylori, enzyme-linked immunosorbent assay kits were utilized. In contrast, the absence of both antibodies (IgG and IgA) resulted in the designation of an H. pylori-negative status. Anti-H pylori immunoglobulin (Ig) G/IgA ≥30 enzyme immune units were classified as H. pylori positive. Chi-square test was used to analyze the obtained data.

Results:

The overall positive seropositive samples among the study participants were 122 (17.2%). The seropositivity was high 42 (34.4%) among the age group 30 <40 years, compared with the other age groups. There was no significant difference between male and female cases regarding the seropositive samples.

Conclusion:

Seroprevalence of H. pylori infection shows a drop comparing to previously local reports. Nationwide epidemiological research is necessary for determining the seroprevalence of H. pylori in Libya.
Potential Linkages between Alzheimer’s Disease and Major Depression
Authors: Raudino Francesco
Published: August 2023

Alzheimer’s disease (AD) and major depression (MD) are frequent diseases with a significant impact on the quality of life, and epidemiological studies show a correlation between early depressive episodes and AD. Although apparently different, they nonetheless maintain significant similarities, such as the common genetic substrate, involvement of similar structures, and a number of common pathogenetic hypotheses. This in-depth literature review aims at highlighting possible linkages between the two diseases: A chronic inflammatory process that selectively alters the blood–brain barrier in certain regions can be hypothesized.
Molecular and Genetic Study for Detection of Helicobacter pylori Virulence Genes among Patients with Diffuse Large B-Cell Lymphoma
Authors: Alhasnawi Eman Abid Fahad , Bakir Wasan Abdulelah
Published: August 2023

Background:

The bacteria Helicobacter pylori (Hp) has supposed to confirm an oncogenic consequence with the evolution of malignancy events in stomach, effectiveness of Hp consider a top risk factor of gastric-diffuse large B-cell lymphoma (DLBCL).

Aims:

the aim of this study was to observe the correlation between virulence factors, especially cytotoxin association gene A (CagA) and the progress of gastric DLBCL.

Materials and Methods:

Biopsy samples (50) involved in this study (28 were men, and 22 women, with a mean age up to 57.64 years), among gastric-DLBCL patients, with (25) control (were 14 men and 11 women) without DLBCL, tested at Medical City Teaching Hospital and Teaching Laboratories, study conducted from January 1st to September 30, 2022. Diagnosis was by molecular methods included DNA extraction for Hp by STR-Format kit (BIORON Diagnostics GmbHm In den Rauhweiden 20,67354 Germany), and “real-time polymerase chain reaction” methods using the (ABI PRISM 7700) Sequence Detection System, also applied the primers and probes, for Hp-CagA.

Results:

The mean of age was 55.7 ± 2 in DLBCL, while in control were 61.82 + 6, CagA +ve 66.66 + 2. In gastric DLBCL, the red blood cell count, white blood cell count, platelets count, and hemoglobin were all decline in DLBCL, not in the control group, lactate dehydrogenase levels in gastric DLBCL patients were rise (322 U/L), while less in control, while albumin (322g/dl) was less in gastric DLBCL patients. Hp 16S rRNA was detected relating to CagA variety, 66% (33/50) were CagA positive with highly significant in 23 patients with DLBCL (P = 0.004), and 10 in control patients. CagA gene expression was highly expression in gastric DLBCL patients with range up to (+), 8 (++), and 12 (+++), while in the control group was 5 (+), 2 (++), and 3 (+++), respectively.

Conclusions:

This present study fixed high frequency of CagA gene in gastric DLBCL patients. Moreover, confirmed this gene is significantly associated with gastric DLBCL in patients with Hp. Moreover, genotype EPIYA-ABC motif is related with the high risk of gastric DLBCL.
Research on Ephemeroptera (Insecta) fauna of Aydın and Denizli (Türkiye) provinces
Authors: AYDINLI Caner , ERTORUN Nesil
Published: August 2023

Although studies on the order Ephemeroptera are at a sufficient level in many of the provinces in the Aegean region, there is no comprehensive study on the provinces of Aydın and Denizli. Until now, four species from Aydın and two species from Denizli province have been reported from the Ephemeroptera order. The research being done in these provinces, which are the study regions, aims to fill in the gaps in the Aegean Area and provide more precise information about the national Ephemeroptera fauna.

With the aid of sieves and water scoops, nymphs were gathered from the habitats of each locality's various biological characteristics during the field experiments, which were conducted in 25 different locations throughout two provinces. Thirteen species were recognized after examination of the 1177 collected specimens.

In the study, five of the species identified from Aydın province and 12 of the species identified from Denizli province were recorded for the first time from the related provinces within the research area.
Uma Proposta para Elaboração e Análise de Tarefas de Aprendizagem Profissional
Authors: Gross Giane Fernanda Schneider , Trevisan André Luis , Araman Eliane Maria de Oliveira , Trevisolli Rosemeire Favaro Lisse
Published: August 2023

No âmbito da formação de professores, é fundamental compreender como os professores mobilizam diferentes conhecimentos para ensinar Matemática e, atrelado a isso, como são geradas Oportunidades de Aprendizagem Profissional (OAP). Nesse sentido, o objetivo deste artigo é apresentar uma proposta para Elaboração e Análise de Tarefas de Aprendizagem Profissional com o intuito de subsidiar a identificação de conhecimentos matemáticos e pedagógicos que são revelados nas reflexões ocorridas em um contexto formativo. Apresentamos, com base em teorias e conceitos fundamentados em pesquisas da área, a análise de uma Tarefa de Aprendizagem Profissional (TAP) discutida por professores participantes de um processo formativo, orientado e conduzido por um formador de professores, ocorrido em uma disciplina de mestrado no primeiro semestre de 2018. Como resultados, identificou-se que os professores, quando discutem tarefas matemáticas, refletem sobre como intervir em sala de aula, mobilizam e (re) significam conhecimentos matemáticos para o ensino, bem como, ampliam as possibilidades de atuação em sala de aula.
FLUCTUACIONES TEMPORALES DE LA BIOMASA Y CONTENIDO DE ALMIDÓN DE PASPALUM FASCICULATUM
Authors: Berrios-Rivera María Y. , Robles Wilfredo , O'Hallorans-Castillo Julia M. , Ortiz-Colón Guillermo
Published: August 2023

FLUCTUACIONES TEMPORALES DE LA BIOMASA Y CONTENIDO DE ALMIDÓN DE PASPALUM FASCICULATUM
Using drug information to bridge basic science with pharmacy practice
Authors: Nguyen Cambrey
Published: August 2023

Background: Drug Information (DI) skills are essential to pharmacists and encompass information retrieval along with literature evaluation on drug characteristics, including foundational sciences. A novel approach was implemented using DI focused learning opportunities to educate first year learners about clinical relevance and integration of basic science concepts into pharmacist knowledge.
Methods: A lecture introduced the integration by mapping sections of a drug’s prescribing information to all courses in the University of Kansas School of Pharmacy curriculum. An innovative activity required students to use the knowledge obtained from concurrent P1 courses to determine the cause of death of a fictional patient. Other activities included answering drug availability questions on the clinical development process and presenting a research article. Assessment of learning was based on student performance.
Results: From 2019 to 2021, the proportion of students who determined the cause of death ranged from 59-67%, and the mean scores for the drug development assignments were 94-95%.  The median score was 8/10 for the rubric item discussing the relevance of the research article to basic science and/or pharmacy practice, and total scores for the presentation ranged from 80-98%.
Conclusion: Based on the results, students demonstrated their understanding of the relationship between basic science and pharmacy practice.
HOT TENSILE PROPERTIES OF INCONEL 706 ALLOY
Authors: Abhishek.S  , Chandru.P  , Navin Kumar.A  , Bharath.G  , Karthik.V
Published: August 2023

INCONEL 706 is a high-strength nickel-based super alloy that is commonly used in high-temperature applications such as gas turbines and nuclear reactors. In this study, the hot tensile properties of Inconel 706 were investigated to better understand the material's behavior under high-temperature and high-stress conditions. Tensile tests were conducted at temperatures ranging from 740°, 860°, 940°, 1020°1080°and strain rates ranging from 0.001/s to 1/s. The results showed that the ultimate tensile strength and yield strength of Inconel 706 decreased with increasing temperature, while the elongation increased. The strain rate had a negligible effect on the mechanical properties. Microstructural analysis revealed that the deformation mechanism changed from dislocation slip to dynamic recrystallization as the temperature increased. The activation energy for deformation was calculated to be 421 kJ/mol, indicating that diffusion-controlled mechanisms play an important role in the deformation process. Overall, the hot tensile properties of Inconel 706 were found to be highly dependent on temperature and microstructure, which should be considered in the design and operation of high-temperature components made of this alloy. The output from the tensile testing machine is used for the data in analysis software like MATLAB, Ansys. The aim of investigations conducted in this project is to study the change of the mechanical properties, especially the high temperature mechanical properties of HTPI, at elevated temperatures.
Bullying in the Education Workspace in India
Authors: Prof. G P. Dinesh  , Dr. Divyabharathi
Published: August 2023

Workplace bullying refers to repeated, unreasonable actions of individuals (or a group) directed towards an employee (or a group of employees), which is intended to intimidate and creates a risk to the health and safety of the employees. Workplace bullying often involves an abuse or misuse of power. Bullying includes behavior that intimidates, degrades, offends, or humiliates a worker, often in front of others. Bullying behavior creates feelings of defenselessness in the target and undermines an individual’s right to dignity at work. Bullying is different from aggression. Whereas aggression may involve a single act, bullying involves repeated attacks against the target, creating an on-going pattern of behavior. “Tough” or “demanding” bosses are not necessarily bullies, as long as their primary motivation is to obtain the best performance by setting high expectations. Many bullying situations involve employees bullying their peers, rather than a supervisor bullying an employee. This paper highlights the reasons for bullying, its consequences and how to prevent this menace in Education Workspace.
Comparing the characteristics of blockchains via building a NFT marketplace
Authors: M Vivaswanth Kashyap  , Vaidya Saideepa  , K Shivadar Reddy  , Mrs.T.Ratnamala
Published: August 2023

Blockchain is a ground-breaking technology that will soon have a significant positive impact on our commercial environment. Non-Fungible Token is referred to as NFT. A digital representation of a real-world item, such as music, art, in-game items, or films, can be referred to as an NFT. They are typically exchanged online using various cryptocurrencies. Different from fungible tokens that are bought or sold on numerous centralised or decentralised exchanges, non-fungible tokens transacted on an NFT marketplace. NFTs are unique. Every NFT has a digital signature that prevents them from being altered for another NFT. Each has a unique value based on a number of variables, including metadata, creator,features, etc. The NFT marketplace, which gives users a platform to create and exchange Non-Fungible Tokens, is meant to be at the centre of all the fantastic use cases for NFTs. The software will be compared to other well-known systems like Opensea, etc., whose major transaction volume is on the Ethereum blockchain network. In this endeavour, we will focus on establishing an NFT Marketplace using the Internet computer. We would interact with the internet computer using Motoko, and the front end of the application would be made with Reactjs.