bluuebunny/crossref_metadata_2025 huggingface dataset:
The Voting Behavior of Kyai And Santri on the Legislative Election of 2019
Authors: Siswanto Akhorin , Supriyadi Supriyadi , Zuber Ahmad
Published: October 2022

Background: Kyai and Santri have a long history in the political dynamics of the Indonesian nation. In addition, the number of Islamic boarding schools and students has experienced significant development, so it is not surprising that Islamic boarding schools are land to gain votes in the general election of legislative candidates.
Aim: This study aims to describe the behavior of Kyai voters in the 2019 Legislative Election and the behavior of Santri voters in the 2019 Legislative Election.
Method: The research uses descriptive qualitative with a case study at the Wisma Wisnu Islamic Boarding School, Madiun Regency. Data analysis was carried out using the approach of sociological theory (The Colombia Study) and rational choice.
Findings: The results showed that; 1) The behavior of Kyai voters in the 2019 Legislative Elections showed a rational choice approach. Kyai was able to assess the quality, competence, and integrity of legislative candidates through vision, mission, and programs; 2) The behavior of Santri voters in the 2019 Legislative General Election showed a sociological approach (The Colombia Study); Santri did not know the vision and program of the future legislative because the students were not involved in the campaign stage, so the consideration in determining the choice of students was due to the direction of the Kyai and partly because of the supervision of the parents.
Disaggregated Analysis of the Effects of Energy Consumption on Greenhouse Gas Emissions in Africa
Authors: Guedie Rolly , Ngnemadon Ali Salim Ahmed , Fotio Hervé Kaffo , Nembot Luc
Published: October 2022

This study investigates the effect of energy consumption on greenhouse gas (GHG) emissions in 33 African countries from 1995–2017. It contributes to the literature by investigating the effect of disaggregated measures of energy consumption (coal, oil and other liquids, renewable energy, and electricity) on GHG emissions (CO2, N2O, CH4, and total GHG emissions) in Africa and identifies the transmission channels through which energy consumption affects GHG emissions. The system GMM is used in the study as it accounts for possible endogeneity and the potential correlation between the error term and the country fixed effects. The results show that coal consumption significantly increases CO2, CH4, and total GHG emissions and reduces N2O emissions. Oil consumption increases CO2 and total GHG emissions but reduces N2O and CH4 emissions. Renewable energy consumption reduces CO2 and CH4 emissions but increases N2O emissions. Finally, electricity consumption promotes CO2, N2O, CH4 and total GHG emissions in Africa. Further analyses show that foreign trade and economic growth are the channels through which oil consumption increases GHG emissions. The adverse effect of electricity is through urbanization. Renewable consumption could decrease GHG emissions through sustainable urbanization and trade policies. The findings suggest that countries should gradually reduce coal consumption and encourage renewable energy consumption, which has the lowest impact on the environment.
Factors influencing treatment outcomes in patients with isoniazid-resistant pulmonary TB
Authors: Velayutham B. , Shah V. , Mythily V. , Gopalaswamy R. , Kumar N. , Mandal S. , Parmar M. , Padmapriyadarsini C.
Published: October 2022

INTRODUCTION: Patients with isoniazid (H, INH) resistant pulmonary TB but undetected rifampicin (R, RIF) resistance are treated with a 6-month regimen of levofloxacin-RIF-ethambutol-pyrazinamide (6LvxREZ) under India´s National TB Elimination Programme (NTEP).OBJECTIVE:
To describe the profile of and treatment outcomes in patients with pulmonary INH-resistant (INHR) TB initiated on TB treatment, and identify factors associated with unfavourable treatment outcomes (died, failed, treatment changed, lost to follow-up).METHODS: This was
a retrospective analysis of NTEP database (Ni-kshay) on pulmonary INHR TB patients initiated on treatment with “H mono/poly regimen” (6LvxREZ) between July 2019 and June 2020 with documented treatment outcomes. Proportions with 95% confidence interval (CI) was calculated
and logistic regression analysis was performed.RESULTS: Of the 11,519 patients with pulmonary INHR TB, 9,440 (82%) had treatment success (55.1% cured, 26.9% treatment completed). Unfavourable treatment outcome was observed in 1,901 (16.5%). Male sex, tobacco and alcohol
use, HIV reactive status were associated with unfavourable treatment outcome. Patients with katG mutations and resistance to fluoroquinolones were likely to have poor treatment outcomes.CONCLUSION: A levofloxacin-based regimen offers a treatment success rate of 82% in patients
with pulmonary INHR TB. Sex-specific strategies, interventions to address smoking and alcohol use, focus on HIV-reactive patients and optimising treatment regimens based on drug susceptibility should be considered for improving treatment outcomes.
A scoping review of interventions to mitigate common non-communicable diseases among people with TB
Authors: Romanowski K. , Oravec A. , Billingsley M. , Shearer K. , Gupte A. , Huaman M. A. , Fox G. J. , Golub J. E. , Johnston J. C.
Published: October 2022

BACKGROUND: Recommendations have been made to integrate screening for common non-communicable diseases (NCDs) within TB programs. However, we must ensure screening is tied to evidence-based interventions before scale-up. We aimed to map the existing evidence regarding interventions
that address NCDs that most commonly affect people with TB.METHODS: We systematically searched PubMed, Medline, and Embase for studies that evaluated interventions to mitigate respiratory disease, cardiovascular disease, alcohol and substance use disorder, and mental health disorders
among people with TB. We excluded studies that only screened for comorbidity but resulted in no further intervention. We also excluded studies focusing on smoking cessation interventions for which evidence-based guidelines are well established.RESULTS: The search identified 20 studies
that met our inclusion criteria. The most commonly evaluated intervention was referral for diabetes care (6 studies). Other interventions included pulmonary rehabilitation (5 studies), care programs for alcohol use disorder (4 studies), and psychosocial support or individual counselling (5
studies).CONCLUSION: There is limited robust evidence to support identified interventions in changing individual outcomes, and a significant knowledge gap remains on the long-term durability of the interventions´ clinical benefit, reach, and effectiveness. Implementation research
demonstrating feasibility and effectiveness is needed before scaling up.
Duplex electroless Ni-P/Ni-Cu-P coatings: Preparation, evaluation of microhardness, friction, wear, and corrosion performance
Authors: Biswas Palash , Das Suman Kalyan , Sahoo Prasanta
Published: October 2022

The current study focuses on the development of duplex Ni-P/Ni-Cu-P coatings by the electro­less deposition method. Coatings are developed on mild steel substrates with Ni-Cu-P as the outer layer and Ni-P as the inner layer and vice versa. The coated samples are heat-treated at temperatures ranging between 200 to 800 °C during 1 and 4 h. Coated samples are characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS) and X-ray diffraction (XRD). The effect of heat treatment tempera­ture and its time duration on the hardness, friction and wear behaviour of both coatings are evaluated and compared. This would help in understanding how heat treatment influences the duplex system of coatings and helps in identifying the suitable condition of heat treatment for optimal performance of the coating. It is observed that heat treatment has a positive influence over the coating performance, which is the best when treated under optimal temperature and time duration conditions. The corrosion behaviour of the coatings is also assessed with the help of electrochemical techniques, viz. potentiodynamic polari­zation and electrochemical impedance spectroscopy. The results show that the duplex coat­ings can provide substantial protection to the mild steel substrates. Heat treatment is also found to have a significant influence on the corrosion behaviour of duplex coatings.
Comparative Study in the Treatment of Candida and Aspergillus with Natural Substances
Authors:   Ovidius University Constanta, Romania, Doctoral School of Applied Science, Field of Biochemistry/ Biology, MOROIANU Olimpia-Nicoleta , POPESCU Nelu-Doru ,   Medstar 2000 Medical Center, Department of Dermatology, Constanţa, Romania, ROŞOIU Natalia ,   “Ovidius” University, Faculty of Medicine, Department of Biochemistry, Constanţa, România; Academy of Romanian Scientists
Published: October 2022

The study analyzes the action of some substances from selected plants, on two mycelial species, aiming at the selection of some natural substances, for the treatment of mycoses such as Candidiasis and Aspergillosis. The most obvious fungicidal results were noticed after the application of marigold and propolis tinctures as well as sage and mint oils. The results of the study can be applied as an alternative in the fight against fungal infections, performed by the usual drug treatment.
"The Role of Intestinal Microbiote in Neuromuscular Diseases in Paralized Dogs"
Authors:   Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania, GIURGIU Gheorghe , COJOCARU Manole ,   Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania
Published: October 2022

In order to be able to move, animals like man need the nervous and muscular system to function optimally. The brain, spine, nerves and muscles must work together. If there is a disturbance, the messages will not reach the destination and the animal will not be able to move. Depending on the location and extent of the neurological lesions, the dog may paralyze in whole or in part. Post-traumatic paralysis is a complex condition that requires proper treatment and thorough investigations to establish an accurate diagnosis. There are several conditions that can cause paralysis in the dog. The interaction between the health of the microbiome and that of the brain as well as the way it communicates immune and neuronal cells has been studied. Intestinal cells affect the cells of the central nervous system in the brain. The intestinal-brain axis may influence different neurological disorders and it is possible that dysbiosis in the intestinal tract may lead to disturbance of the transmission of nerve controls on the neuromuscular plate. By-products of microorganisms in the intestine, which appear as a result of tryptophan processing in the diet, can limit the level of inflammation in the brain by the influence they have on microglial cells. The current research focuses on the influence that the gut microbiota has on microglial cells and astrocytes that play an important role in the health of the central nervous system. To reach these observations, the authors examined how intestinal microbiota and diet influence amelioration of paralysis in dogs. In conclusion, the link between the health of the microbiome and the health of the brain, shows how the microorganisms in the intestine influence the evolution of paralysis.
Natural Neuroimunomodulation in Coronavirus Infection
Authors:   Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania, GIURGIU Gheorghe , COJOCARU Manole ,   Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania
Published: October 2022

Dysbiosis of the nasopharyngeal microbiome attracts dysbiosis of the intestinal microbiome and activation of the intestinal microbiome-brain axis. If the first sign of the disease is quickly intervened with the modulation of the activity of the microbiome, implicitly of the immune system (neuroimmunomodulation), the appearance of the disease is eliminated. There is the microbiome: buccal, nasal, intestinal, cardiac, cutaneous and even the microbiome in the brain with which Covid-19 interacts. When the evolution is complicated, it is necessary to intervene with drug treatment to support the affected organs. Although there is also renal impairment, no coronaviruses or traces were found in the patients' urine. Knowing that the infection also causes digestive symptoms, coronaviruses have been shown in faeces. It is said that in 1-2% of cases Covid-19 reaches the bloodstream. The microbiome is essential for promoting immune function to prevent and combat disease. Specifically, with regard to viral infections, there must be an adequate immune response to protect the body. The intestinal microbiota with low diversity will consequently lead to a deficient immune function. The microbiota, the intestine and the brain communicate through the microbiota-intestine-brain axis in a bidirectional way. We assume that the Covid-19 virus creates a dysbiosis of the intestinal microbiome. A healthy gut microbiome is crucial in creating an adequate response to coronavirus. A diverse microbiome is a healthy microbiome, which contains many different species that each play a role in immunity and health. The motivation of the project is the study of the influence of the intestinal microbiota in terms of health and the appearance of symptoms in Covid-19 infection. With the help of Deniplant brand natural remedies, the authors have developed several products for autoimmune, metabolic and neurological diseases that act as immunomodulators of the human microbiome.
IMPROVING THE TECHNOLOGICAL WELDING PROCESS IN THE CONDITIONS OF SUSTAINABLE DEVELOPMENT
Authors:   Departament of Management, Faculty of Management in Production and Transportation, Politehnica University of Timisoara, Timisoara, Romania, IVAȘCU Larisa , CIOCA Lucian-Ionel ,   Department of Industrial Engineering and Management, Faculty of Engineering, Lucian Blaga University of Sibiu, Academy of Romanian Scientists
Published: October 2022

In the current conditions of sustainable development requirements, it is important to evaluate the activities of companies in the industry. This assessment is important from the perspective of improving the impact of organizations on the environment. The first step towards improving the organizational footprint on the environment is to replace the process of joining flame bonding with laser bonding because the amount of CO2 emissions generated is minimal, compared to flame bonding where the amount of CO2 emissions is much higher. A series of theoretical implications are presented that underlie the presentation of a case study that was conducted in a company in the automotive industry. Finally, a series of management activities are presented that contribute to the improvement of the organizational footprint of CO2.
Development and Integration of Photovoltaic Complex Systems in Optoelectronic and Power Applications
Authors:   Faculty of Electronics, Telecommunication and Informational Technology, PUB, Independence 313, CRACIUNESCU Dan , FARA Laurentiu ,   Academy of Romanian Scientists, Bucharest, Romania, Polytechnic University of Bucharest, Faculty of Applied Sciences, STERIAN Paul ,   Academy of Romanian Scientists, Bucharest, Romania, Polytechnic University of Bucharest, Faculty of Applied Sciences
Published: October 2022

This thesis presented innovative dimensioning and implementation of autonomous photovoltaic systems is primarily aimed at ensuring the energy independence of the receiver (consumer), the security of electricity supply and the adaptation to meteorological conditions in the area where they are located. The PV system components are based on literature, but their characterization was possible by implementing the components / system in the MATLAB / Simulink work environment to determine the behavior and performance of the analyzed system for different applications. We also analyzed the interdependence of the subsystems and how they affect the efficiency of the PV system. The main contribution of this paper is based on MPPT method and FLC controller used in order to optimize the behavior of applied PV systems
ALPHA-RESONANCES IN MEDIUM AND HEAVY NUCLEI I. Review of phenomenological models
Authors:   Horia Hulubei National Institute for Physics and Nuclear Engineering, Delion D.S. , Dumitrescu A. ,   Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering, Baran V. V. ,   Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering
Published: October 2022

"The low-lying rotational bands in light nuclei were explained a long time ago by α-clusters orbiting around the remaining core. These quasimolecular states are related to an enhancement of the elastic α-particle cross section at large angles, the so-called Anomalous Large Angle Scattering (ALAS) phenomenon. On the other hand, α-particles were evidenced by the discovery of the α-decay for nuclei with Z > 50. We used a phenomenological model of an α-particle moving in a pocket-like potential, able to explain the ALAS phenomenon, in order to understand the main features of the decay data between ground and excited states. Then we extended the Brink model, explaining giant resonances, and presented a possibility to detect α-like collective resonances."
Notes on Fission Dynamics
Authors:   Academy of Romanian Scientists, Splaiul Independentei 54, 050094 Bucharest, Romania, Mirea M. ,   Horia Hulubei National Institute for Physics and Nuclear Engineering, P.O. Box MG-6, 077125 Bucharest-Magurele, Romania
Published: October 2022

The dynamics of the nuclear fission is a complex phenomenon, being not yet described adequately from the theoretical point of view. At present, they are not models giving a complete description of the richness of the features which characterizes this phenomenon. It is the mean reason for which I called this paper Notes on Fission Dynamics, being certain that I will not be able to make a global description, but only a picture underlining some particularities. So, this mini-overview should be considered only a part of the collection of articles treating the nuclear physics, published as a special number in the review of the Academy of Romanian Scientists, without an exhaustive character. A theory treating the nuclear fission is by excellence based on quantum mechanics. That is, a theory concerning the interactions between the smallest pieces that constitute a many-body nucleus. But, at present it is not possible to perform ab-initio calculations to describe the many-body structure of heavy nuclei which undergo fission by starting from fundamental interactions. To make the problem tractable, the nucleus as a whole are constrained by some collective parameters, associated to some collective degree of freedom. The collective variables are forced to vary, leading to a scission of the nuclear system. The response of the nuclear system to the external forces is given by the nuclear inertia. The mean field potential between the nucleons is obtained after a proper average, and then used to solve the Schrodinger equation. The treatments presented in this article are based on these simplifying concepts. I will give some examples of calculations that include the dissipation and the configuration mixing due to radial and angular couplings. The importance of the subject is also briefly reviewed.
CONSIDERATIONS ABOUT NON-PSYCHOTROPIC CANNABINOIDS AND THEIR POTENTIAL APPLICATIONS
Authors:   Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, Romania, BANU Geanina Silviana , COSTACHE Nicolae ,   Trans Nobili Rosales S.R.L., Sibiu, Romania, FICAI Anton ,   Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Bucharest, Romania, corresponding member of the Academy of Romanian Scientists
Published: October 2022

Non-psychotropic cannabinoids, as well as psychotropic cannabinoids, extracts of Cannabis sativa L. and derived products containing cannabinoids have gained the status of novel foods within the European Union/EU, starting January 2019, thus requiring authorization for the placing on the EU market. With this status comes also the consolidation of an emerging market. At the same time, it should be noted that cannabinoids have already been the object of research, study and applications, for at least decades of modern science, showing comprehensive and extraordinary properties for use as therapeutic agents. The purpose of present paper is to provide an overview of the main non-psychotropic cannabinoids and their pharmacological profiles, with the aim of advocating further research into their potential for various applications, mainly as therapeutic agents, and most importantly with the aim of advocating for pursuing the innovation process all the way to the market uptake of related innovative products.
SUSTAINABLE ALTERNATIVES FOR HAZARDOUS WASTE MANAGEMENT
Authors:   ”Gheorghe Asachi” Technical University of Iasi, ”Cristofor Simionescu” Faculty of Chemical Engineering and Environmental Protection, VRÂNCEANU Tania , COMĂNIȚĂ UNGUREANU Elena-Diana ,   ”Gheorghe Asachi” Technical University of Iasi, ”Cristofor Simionescu” Faculty of Chemical Engineering and Environmental Protection, LAZĂR COȘBUC Ersilia ,   ”Gheorghe Asachi” Technical University of Iasi, ”Cristofor Simionescu” Faculty of Chemical Engineering and Environmental Protection, COZMA Petronela ,   ”Gheorghe Asachi” Technical University of Iasi, ”Cristofor Simionescu” Faculty of Chemical Engineering and Environmental Protection, TUDORACHE Daniela Ionela ,   ”Gheorghe Asachi” Technical University of Iasi, ”Cristofor Simionescu” Faculty of Chemical Engineering and Environmental Protection, GAVRILESCU Dan-Alexandru ,   ”Gheorghe Asachi” Technical University of Iasi, ”Cristofor Simionescu” Faculty of Chemical Engineering and Environmental Protection, GAVRILESCU Maria ,   ”Gheorghe Asachi” Technical University of Iasi, ”Cristofor Simionescu” Faculty of Chemical Engineering and Environmental Protection
Published: October 2022

In order to ensure a sustainable economic and social development and maintain the quality of the environment, adequate waste management and conservation of natural resources are required. It is therefore necessary to apply an integrated waste reprocessing and recycling system, based on specific technologies, which facilitate, in the first stage, the recovery of valuable waste materials and, subsequently, the recovery of all materials and energy. Among the waste generated, a significant quantity is classified as hazardous waste. This paper has as main objective the analysis of waste management alternatives with an emphasis on hazardous waste management. Small and large generators of hazardous waste and environmental impact are considered as well as options for reducing hazardous waste quantities. Following an algorithm proposed in literatureh, the decision of appropriate methods of treatment and disposal of hazardous waste is made based on three main factors: physical state of hazardous waste, hazard criterion, composition criterion. On this basis, specific schemes for hazardous waste processing and disposal were established. A special attention was paid to alternatives for the treatment and disposal of hazardous waste in the form of accumulators
Lärare i årskurs 5 planerar historieundervisning med fokus på skriftliga resonemang
Authors: Hugo Heléne
Published: October 2022

I och med införandet av den svenska läroplanen 2011 (Skolverket, 2017a) ska eleverna få en mer vetenskapligt präglad historieundervisning, där de lär sig ett historiskt tänkande. Ett krav på undervisningen är att eleverna ska utveckla sin förmåga att resonera i ämnet (Skolverket, 2017a). Studien tar sin utgångspunkt i detta förändrade krav och specifikt i förmågan att resonera skriftligt. Artikeln belyser sju planeringstillfällen och ett avslutande samtal, där två årskurs 5-lärare och jag planerar historieundervisning med fokus på skriftliga resonemang. Syftet med studien är att bidra med kunskap om lärarnas uppfattningar av hur undervisningen kan utformas så att den stöttar eleverna i att utveckla denna förmåga. För att få kunskap om lärarnas uppfattningar av vad ett skriftligt historiskt resonemang innebär, genomfördes deltagande observation och en fenomenografisk analys. Resultatet visar att lärarna uppfattar skriftligt resonerande i historia som a) förståelse av det historiska innehållet, b) aktiv användning av innehållsbegrepp, c) växling mellan tids- och rumsperspektiv och d) urskiljande av textkvalitéer. Därefter gjordes en tematisk analys, som visar att undervisningen, enligt lärarna, behöver innehålla användande av läromedel, vara visuellt stödjande, kollaborativ, reflekterande och dessutom beakta textstruktur och språkliga mönster. Sammanfattningsvis visar resultaten på komplexiteten i att planera historieundervisning för yngre elever, där de ska ges möjlighet att både utveckla historiskt tänkande och att utveckla förmågan att föra skriftliga historiska resonemang
Extra-occupational Psychosocial Factors that affect the nursing staff of the Hospital General de Agudos Parmenio Piñero
Authors: Garay Pardo Robinson Ali , Parra Ricardo Adrián
Published: October 2022

Introduction: contemporary society is characterized by being structured by social, economic, labor and academic dynamics that make greater demands on nurses every day.
Aim: to characterize the extra-occupational psychosocial risk factors affecting nursing personnel.
Methods: A descriptive, non-experimental, cross-sectional, quantitative research was carried out. The sample consisted of 150 health professionals. To measure the variables to be studied in this research, the Battery of instruments for the evaluation of psychosocial risk validated by the Ministry of Social Protection of the Republic of Colombia was used. Descriptive statistics were used.
Results: regarding family relationships, it was observed that 47,4 % of the respondents were not at risk in this dimension. Regarding the dimension of communication and interpersonal relationships, 20,1 % of the respondents were found to be at very high risk. Regarding the characteristics of the dwelling and its environment, 59,7 % were found to be at very high risk. When analyzing the influence of the extra-work environment on work it was observed that 28,6 % are at very high risk.
Conclusions: nursing personnel are exposed to extra-work psychosocial risk factors, so actions should be aimed at both promotion and prevention, as well as intervention of these factors so that they do not interfere in the future with the work environment or be the beginning of deterioration and physical as well as mental wear and tear in nursing personnel
Importance of rest and family relations as non-work psychosocial factors that affect nursing staff
Authors: Garay Pardo Robinson Ali , Parra Ricardo Adrián
Published: October 2022

Currently, the issue of staff well-being is addressed from many perspectives of the labor spectrum, but in the background of these approaches the intention to improve the rest conditions of health workers and thus influence their family relationships can be found. The ways in which health professionals perceive and take advantage of these rest periods and how they influence their family dynamics are an important part of the challenges of managing health personnel in institutions. Despite the current working conditions and demands, rest and family relationships stand as protective psychosocial factors for the well-being of the nursing professional. Regarding family relationships, the work-family conflict is the main problem on which the efforts of the institutions should be focused to improve the status of their professionals
Bioethanol Producing from Sorghum Crops
Authors: GAMAYUNOVA V. , KHONENKO LYUBOV , KOVALENKO O.
Published: October 2022

The relevance of the article lies in a comprehensive analysis of the trend in the production of biofuels from crop products in Ukraine and other countries of the world. The purpose of the research was to justify on the basis of research by both their own and many authors that sorghum varieties are extremely important in cultivation due to changes in soil and climatic conditions. When conducting research, we used generally accepted methods, techniques and DSTU, in particular: the method of comparison, analysis and synthesis, laboratory and field. Computer methods of information processing and visualization of research results using the Microsoft Office program were also used. According to the results of research, it was found that with less favorable temperature conditions and moisture supply in 2020 yr., grain sorghum crops formed a yield depending on the hybrid in the range of 2.1-6.9 t/ha, in a more favorable year for these indicators in 2021 yr. it was at the level of 6.9-14.5 t/ha, and on average for two years it was in the range of 4.5-10.7 t/ha. Performance stability was determined in the U 60117 IG and Bianca hybrids. On average, over two years, the theoretical yield of biofuels, depending on the hybrid, ranged from 2216 up to 5199 l/ha with a starch content in the grain of more than 75%. The highest estimated alcohol yield per unit area was in the grain sorghum hybrid U 60116 IG, which combines a stable yield (10.7 t/ha) with a high starch content in the grain (75%). Treatment of sugar sorghum crops with biologics and microfertilizers had a positive effect on the yield of structural units per hectare: compared to the control, the yield of leaves during organic balance processing increased by 2.66 t/ha, the yield of panicles – by 1.56 t/ha, and stems – by 3.64 t/ha. The increase in the conditional yield of sugars relative to the control of treatment with Quantum microfertilizers was 0.354 t/ha, organic balance – 0.417 t/ha, and with their combined action – 1.143 t/ha, which was the maximum value
The Potential of Cinnamon Extract (Cinnamomum burmanii) as Anti-insomnia Medication through Hypothalamus Pituitary Adrenal Axis Improvement in Rats
Authors: Hidayat Rachmat , Wulandari Patricia , Reagan Muhammad
Published: October 2022

Objective. This study aimed to explore the efficacy of cinnamon extract as an anti-insomnia medication in experimental animals by evaluating the levels of hormones and neurotransmitters related to insomnia. Materials and Methods. A total of 30 male Wistar rats were divided into six groups. Induction of insomnia in animal models was done by administration of p-chloro-phenylalanine (PCPA) compounds. Estazolam was administrated to the positive control group. Cinnamon extract administration was divided into 3 doses, namely: 25 mg/kg BW, 50 mg/kg BW and 100 mg/kg BW. Evaluation of the organ coefficient was conducted to evaluate drug toxicity to the organs. The enzyme-linked-immunoassay method assessed hormones and neurotransmitters in the serum and hypothalamus related to insomnia. Results. There was a decrease in the adrenal coefficient in the cinnamon extract group compared to the PCPA group (0.011+0.001, P<0.05). In addition, there was a decrease in the corticotropin-releasing hormone, adrenocorticotropin hormone, and corticosterone levels in the serum of animals who received cinnamon extract. Our study found a dose of cinnamon extract of 50 mg/kg BW was the best dose to balance neurotransmitter levels in insomniac rats.Conclusion. The cinnamon extract increased serotonin and melatonin levels and decreased norepinephrine levels in the insomnia-induced group. Cinnamon extract has potential as an anti-insomnia medication through hypothalamus-pituitaryadrenal axis improvement and brain neurotransmitter regulation in an animal model of insomnia.
Türkiye’de Sanayi Üretiminin İhracat ve İthalat Üzerindeki Etkisi:ARDL Sınır Testi ile Bir Değerlendirme
Authors: DOĞANER Ayça
Published: October 2022

Bu çalışmada, Türkiye’de 2013-Q1 – 2022-Q2 dönemlerinde sanayi üretimi ile ihracat ve ithalat arasındaki ilişkiler incelenmektedir. Sanayi üretimini temsilen toplam sanayi üretim endeksi verisi, ihracatı temsilen ihracat miktar endeksi ve ithalatı temsilen ithalat miktar endeksi verilerinin kullanıldığı bu çalışmada serilerin durağan olup olmadıkları geleneksel birim kök testleri ile tespit edilmiştir. Serilerin durağanlık tespitinden sonra otoregresif dağıtılmış gecikme modeli ARDL testi gerçekleştirilmiştir. Yapılan analiz sonuçlarına göre, Türkiye’de sanayi üretimi ile ihracat ve ithalat arasındaki meydana gelen artış ve azalışların birbirlerine etki ettikleri tespit edilmiştir. Türkiye için 2013-Q1 – 2022-Q2 dönemlerinde, söz konusu etkinin hem ihracat miktar endeksi hem de ithalat miktar endeksi için pozitif olduğu tespit edilmiştir. Analiz sonuçlarına göre, bağımsız değişkenlerin ikisi de istatistiki olarak anlamlı bulunmuştur. Buna göre, sanayi üretim endeksinde meydana gelen %1 birimlik artışın ihracat miktar endeksini %0.67 oranında, ithalat miktar endeksini ise %0.79 oranında artırdığı tespit edilmiştir.
Emo-Sensory Communication, Emo-Sensory ‎Intelligence and ‎Gender
Authors: Naji Meidani Elham , Makiabadi Hossein , Zabetipour Mohammad , Abbasnejad Hannaneh , Firoozian Pooresfehani Aida , Shayesteh Shaghayegh
Published: October 2022

The evolutionary definition of intelligence has made it a ‎multifaceted concept. Emo-sensory ‎intelligence (ESQ), as integration ‎of emotional intelligence (EQ) and sensory intelligence ‎‎(SQ) is the ‎sensitivity to the emotions evoked by sensory inputs. It puts ‎emphasis on ‎individuals’ ability to recognize, label, monitor, and ‎manage sense-induced emotions to guide ‎one’s behavior and ‎establish emo-sensory communication. Among the studies done ‎on ‎different types of intelligence and effective communication, ‎gender differences have been a ‎recurring theme. The purpose of this ‎study was to investigate the role of gender in emo-‎sensory ‎intelligence and emo-sensory communication. To this aim, the emo-‎sensory ‎intelligence scale (ESIS) was distributed to 1500 participants. ‎The results revealed significant ‎differences between the two genders ‎in ESQ for visual, olfactory, and tactile senses, ‎demonstrating the ‎superiority of females over males. Moreover, a significant difference ‎was ‎found between the two genders in their ability to identify the ‎basic emotions triggered by ‎their senses, and use them in their ‎communications, with females being better than males.
مقصد العدل في القرآن الكريم
Authors: العوا سليم
Published: October 2022

تستهدف هذه المحاضرة الهامّة والجميلة البحث في قضيّة هامّة جدّا تتناول أعظم مقصد في كتاب الله تعالى، ألقاها الأستاذ الدكتور محمد سليم العوّا في إطار دورة «مقاصد القرآن الكريم» في نسختها الثانية، والتي انعقدت بمدينة المحمّديّة بتاريخ 26 و27 رجب 1437هـ/ 4 و5 ماي 2016م، وتعاون على تنظيمها كل من مركز دراسات مقاصد الشريعة الإسلامية (بلندن)، ومركز المقاصد للدراسات والبحوث (بالرباط)، وشعبة الدراسات الإسلامية بكليّة الآداب والعلوم الإنسانيّة (بالمحمدية). وتحتوي هذه المحاضرة الرصينة التي تتناول موضوعا على جانب كبير من الأهمية، على تعريف شامل بالعدل، والعدل في النص القرآني، وتحقيق العدل بالنهي عن الظلم ، والعدل في قصص القرآن وأمثاله، والعدل عند العلماء. وقد تطرق الأستاذ الدكتور محمد سليم العوّا في هذه المحاضرة إلى أهم عناصر الموضوع، وقلّب مختلف وجوهه، رغم محدودية حجمه التي يفرضها المقام والنظام، وقد استوفاها بصياغة تقنينية مدقّقة ومنظّمة ومحكمة، وبذل فيها جهدا علميا كبيرا وواضحا.
Anticancer Peptides Prediction: A Deep Learning Approach
Authors: Kaleem Hassan , Rukhsar Sundas , Khalid Muhammad Noman
Published: October 2022

Anticancer peptides play a vital role in the treatment of cancer, due to that it has gained a lot of attention. Several machine learning and deep learning algorithms were developed for the prediction of anticancer peptides. Machine learning algorithms involves features extraction from the dataset and then model is trained to make predictions. In machine learning algorithms features extraction and the training of the model takes a lot of time and efforts, this is a complex process for biologists and biochemists. On the other hand deep learning algorithms require a large amount of dataset for training and accurate predictions. This study has proposed a deep learning algorithm which can be trained on smaller dataset because it uses hyperparameter optimization framework for the accurate predictions of anticancer peptides. The deep learning model has outperformed all the other algorithms and achieved the optimal 99% Acc and 0.982 MCC on Main dataset, 98% Acc and 0.972 MCC on Alternative dataset. The code is available at Github for validation purposes [33].
MECHANISMS AND MANIFESTATIONS OF T CELL-MEDIATED HYPERSENSITIVITY WITH INTOLERANCE TO VARIOUS GROUPS OF ANTI-TUBERCULOSIS DRUGS
Authors:   M.M.Averbakh Central TB Research Institute, Moscow, Russia, Averbakh M.M. , Kosmiadi G.A ,   G.A Kosmiadi Central TB Research Institute, Moscow, Russia, Gergert V.Ya. ,   V.Ya.Gergert Central TB Research Institute, Moscow, Russia
Published: October 2022

The review presents current data on the possibility of immunological diagnosis of adverse reactions to various groups of anti-tuberculosis drugs (first-line anti-TB drugs, aminoglycosides, fluoroquinolones). Literature data are analyzed in terms of two possible types of drug interactions with the immune system. According to the first type, drugs bind covalently to endogenous proteins to form hapten-carrier complexes and induce a T-cell response. The second type of pharmacological interaction (p-i concept) involves drug interactions with antigen-recognizing receptor (TCR) molecules and/or major histocompatibility complex (HLA) proteins. Various clinical manifestations of anti-TB drug intolerance, caused by certain mutations in the lysosomal or mitochondrial apparatus of somatic cells of various organs, cause disturbances in tissue metabolism and activate Th-1 and Th-2 links of cellular immunity with the production of a different spectrum of cytokines, which is the basis for the development of immunological approaches to the detection of causes of intolerance. DOI: 10.57014/2587-6678-2022-3-22-36 Keywords: anti-tuberculosis chemotherapy drugs, side reactions, immune reactions, methods of determination.
PSYCHOPATHOLOGICAL STATUS OF PATIENTS WITH PULMONARY TB AND ITS ASSOCIATION WITH EARLY MALADAPTIVE SCHEMAS
Authors:   V.V.Streltsov Central ТВ Research Institute, Moscow, Russia, Streltsov V.V. , Kharitonova . N.Yu. ,   N.Yu.Kharitonova Central ТВ Research Institute, Moscow, Russia, Baranova G.V. ,   G.V.Baranova Central ТВ Research Institute, Moscow, Russia
Published: October 2022

The article provides data of an analytical correlation study based on hospital data on general severity of psychopathological symptoms, maladaptive schemas, and coping strategies in patients with pulmonary TB. The study involved 78 patients with pulmonary TB aged 18 to 60 years who received treatment at the Central TB Research Institute in 2019–2021. There were 61 (78.2%) women and 17 (21.8%) men. Sixty-five (83.3%) patients were new cases, and 13 (16.7%) patients were previously treated cases. We evaluated severity of psychopathological symptoms (SCL-90-R questionnaire), features of coping with stress (the Coping Strategies questionnaire), and severity of emotional and cognitive patterns associated with childhood experience (YSQ-S3R questionnaire). We established that all the above schemas were more severe in patients with high GSI scores. Patients with low GSI scores did not update addiction/helplessness or defectiveness/shame schemas (feelings of helplessness, inferiority, and shame). Patients with high GSI scores maximally updated abandonment/ instability, unrelenting standards/hypercriticalness, negativity/pessimism, and approval-seeking schemas, as well as escape/avoidance and confrontation coping strategies. There were also inverse correlations between confrontation coping strategy and failure, emotion inhibition schemas; planned problem-solving coping strategy and failure, addiction/ helplessness or subjugation schemas. Diagnosis of maladaptive personality traits is important for the prediction and prevention of a patient’s unfavourable reactions to treatment.Keywords: pulmonary TB, psychological characteristics, severity of psychopathological symptoms, early maladaptive schemas, coping strategies
Macrophage phenotypic plasticity during inflammation in patients with pulmonary sarcoidosis or tuberculosis
Authors:   L.N.Lepekha Central TB Research Institute, Lepekha L.N. , Erokhina M.V. ,   M.V.Erokhina Central TB Research Institute, Demyanenko N.G. ,   N.G.Demyanenko Central TB Research Institute, Shcherbakova E.A. ,   E.A. Shcherbakova Central TB Research Institute, Ergeshov A.E. ,   A.E.Ergeshov  Central TB Research Institute
Published: October 2022

Pulmonary macrophages form a heterogenous population of mononuclear cells, which provides systemic defense of an organ from any impairments of structural homeostasis. Functional mobilization of pulmonary macrophages is especially expressed in the development of granulomatous reactions, differentiation of circulating monocytes in pro-inflammatory macrophages, which play the key role in the progression and reparation of inflammatory processes. Phenotypic plasticity of these cells in the context of delayed-type hypersensitivity reaction and developing epithelioid cell granuloma genesis like in pulmonary TB or sarcoidosis represent an important area of research. The present review includes long-term ownstudies of phenotypic plasticity of pulmonary macrophages in TB or sarcoidosis. Biomarkers for verification and differential diagnosis of these diseases have been described. Structural and functional features of the M1 and M2 phenotypes, which differ in the expression of surface markers and cytokine production, were established. It was demonstrated that the M1 phenotype with hypersecretion of epithelioid cells prevailed in pulmonary sarcoidosis patients while the mixed phenotype with active secretion and phagocytosis, i.e. M1/M2 with the predominant M2 phenotype, was typical for disseminated pulmonary TB patients.
APPROACHES TO TIMING OF SURGICAL MANAGEMENT OF TUBERCULOUS PLEURISY IN CHILDREN IN THE CONTEXT OF GROWING INCIDENCE OF MULTIDRUG–RESISTANT TB
Authors:   I.Yu.Petrakova  Central TB Research Institute, Moscow, Russia, Petrakova I.Yu. , Gubkina M.F. ,   M.F.Gubkina Central TB Research Institute, Moscow, Russia, N.I. Pirogov Russian National Research Medical University, Moscow, Russiasia,, Bagirov M.A. ,   M.A.Bagirov Central TB Research Institute, Moscow, Russia,3 Russian Medical Academy of Postgraduate Education, Moscow, Russia, Lepekha L.N. ,   L.N.Lepekha Central TB Research Institute, Moscow, Russia, Larionova E.E. ,   E.E. Larionova .,Central TB Research Institute, Moscow, Russia, Yukhimenko N.V. ,   N.V.YukhimenkoCentral TB Research Institute, Moscow, Russia, Khokhlova Yu.Yu. ,   Yu.Yu. Khokhlova Central TB Research Institute, Moscow, Russia, Sterlikova S.S. ,   S.S.Sterlikova .Central TB Research Institute, Moscow, Russia
Published: October 2022

Objective: to develop criteria for timing of surgical management of paediatric tuberculous pleurisy in the context of growing incidence of multidrug-resistant TB. Materials and methods. We analyzed case histories of 39 children aged 3–12 years treated in our hospital for tuberculous pleurisy in 2010–2019. Criteria for optimal timing of surgery for tuberculous pleurisy in children were elaborated considering clinical features and imaging-based examinations before and during TB treatment. Results. We developed criteria for timing of surgical management of paediatric tuberculous pleurisy. Thirty-one patients underwent surgery for tuberculous pleural empyema before TB treatment (6 patients), 2 months after TB treatment initiation (22 patients), and 6 or more months after TB treatment initiation (3 patients). Eight children with tuberculous exudative pleurisy did not need surgery. Conclusion. Surgical management before TB treatment is indicated for the combination of the following criteria: single or multiple pleural encapsulations detected by imaging-based examinations, lack of dominating TB processes in other anatomical sites. Surgical management after 2–3 months of TB treatment is indicated if exudative pleurisy transforms into pleural empyema in the absence of dominating TB processes in other anatomical sites. Surgical management after 6 or more months of TB treatment is indicated in the presence of a dominating TB process in the lungs after its stabilization.Keywords: TB, pleurisy, pleural empyema, children, surgery, multidrug resistance
IMPROVEMENT OF TREATMENT EFFECTIVENESS IN PATIENTS WITH ACUTE PROGRESSIVE INFILTRATIVE OR DISSEMINATED PULMONARY TB BY THE CORRECTION OF NEOPTERIN AND RANTES LEVELS
Authors:   O.G.Chelnokova Yaroslavl State Medical University, Yaroslavl, Russia, Chelnokova O.G. , Baranov A.A. ,   A.A.Baranov Yaroslavl State Medical University, Yaroslavl, Russia, Takhkhan . A. ,   A.Takhkhan Yaroslavl State Medical University, Yaroslavl, Russia
Published: October 2022

Objective: to improve effectiveness of treatment for acute progressive destructive infiltrative or disseminated pulmonary TB using individualized pathogenetic therapy based on neopterin and RANTES levels in blood serum. Materials and methods. We studied neopterin and RANTES levels in 36 patients with infiltrative or disseminated TB with lung cavities and acute progression at the time of diagnosis, 37 patients without signs of acute progression, and 30 healthy donors. Results. Neopterin and RANTES levels were higher in patients with signs of acute progression of destructive pulmonary TB; they were referred to diagnostic criteria for acute progressive course of TB at neopterin levels more than 26.5 nmol/L and RANTES levels more than 83 387 pg/mL. Low levels of neopterin (less than 9.6 nmol/L) were in patients with advanced acute progressive pulmonary TB and severe comorbidities; it was prognostically unfavourable as well as at RANTES levels more than 83 387 pg/mL. Neopterin and RANTES levels were decreasing at slow rates in patients with acute progression of TB at the time of diagnosis. Administration of gamma-D-glutamyl-tryptophan sodium to patients with high levels of neopterin and glutamyl-cysteinyl-glycine disodium to patients with low levels of neopterin fostered recovery of neopterin and RANTESlevels by the 6th month of treatment in patients with acute progressive TB; it correlated with positive treatment outcomes and cure within 24–36 months in 87% of patients vs 19% of patients, which did not receive personalized pathogenetic therapy. Conclusion. The study demonstrated effectiveness of individualized immunotherapy in the treatment for acute progressive pulmonary TB. Keywords: TB, neopterin, RANTES, acute progressive TB, immunotherapy
Open Science Policy in the European Union
Authors:   Information Society Development Institute, Republic of Moldova, Cuciureanu Gheorghe , Donici Valentina ,   Moldova State University
Published: October 2022

The article analyzes the main initiatives and mechanisms for the promotion of Open Science in the European Union. The good practices and solutions that may be useful for national Open Science policies are identified.
The role of open bibliometric data in determining of dynamics of science development
Authors:   Technical University of Moldova, Cujba Rodica
Published: October 2022

The study includes a brief introduction to Science of Science. The paper presents the results of the analysis regarding the development of modern science carried out by applying bibliometric methods. The study was conducted on the basis of open data provided by the Scimago portal, taken and aggregated from Scopus – one of the largest academic bibliographic databases. The analysis of the dynamics of the development of science at the global level, at the regional level and by fields of science is presented. Relative indicators are used to perform the comparative analysis between regions, countries and fields of science.