bluuebunny/crossref_metadata_2025 huggingface dataset:
Endometrial expression of leukemia inhibitory factor in women with different estrogen/progesterone receptor status of the endometrium
Authors: Aganezov S. S. , Ellinidi V. N. , Morotskaya A. V. , Artemyeva A. S. , Nyuganen A. O. , Aganezova N. V.
Published: July 2019

Aim:to analyze the endometrial expression of leukemia inhibitory factor (LIF) related to the estrogen/progesterone receptor endometrial status in women with the history of reproductive dysfunctions.

Materials and methods.The main group consisted of patients with the history of infertility (n = 81) or early pregnancy loss (n = 40). The control group included 16 women with normal fertility. At days 6–8 after ovulation, endometrial biopsy was performed and peripheral blood samples were taken to assess the estradiol and progesterone levels. Histological and immunohistochemical (to quantify the estrogen (ER)/progesterone (PR) receptors and LIF expression) examinations of the endometrium biopsy materials were carried out.

Results.In the middle phase of the secretion, women of the control group showed higher levels of LIF expression in the endometrial glands (94%; n = 15) and stroma (88 %; n = 14) significantly more often than patients with reproductive dysfunctions – 69 % (n = 84) and 44 % (n = 53) respectively (p < 0.05). There was no difference in the endometrial LIF expression between women with infertility and those with early pregnancy loss. In women with a sizable hormone-receptor 'response', a pronounced expression of LIF in the luminal epithelium (87 %; n = 52 out of 60) and stroma (68 %; n = 47 out of 69) was detected more often (p < 0.01) than that in patients with impaired hormone-receptor interactions (61 %, n = 27 of 44; 29 %, n = 20 of 68). High PR expression in the endometrial glands (H-score > 105) indicates the risk of impaired LIF expression in the luminal epithelium (OR =2.6) and stroma (OR = 2.5). Overexpression of ER (H-score > 155) in the endometrial stroma is associated with the risk of sub-normal LIF expression in the endometrial glands (OR = 2.5) and stroma (OR = 2.8).

Conclusion.A meaningful connection has been found between the endometrial estrogen/progesterone receptor status and the expression of LIF. Women with well-pronounced endometrial hormone-receptor interactions show high levels of endometrial LIF expression more often. The stromal ER and glandular PR expression levels are considered to be prognostic factors of reduced endometrial LIF expression in the uterine body mucosa.
Incidence of complications after laparoscopic and hysteroscopic surgeries for uterine myomas
Authors: Alizade N. K.
Published: July 2019

Aim: to assess the incidence of complications after laparoscopic and hysteroscopic myomectomy.

Materials and methods. The results of 378 laparoscopic and 292 hysteroscopic surgeries for uterine fibroids (myomas) have been retrospectively analyzed. All patients were examined for their history of gynecological and concomitant non-gynecological diseases, past surgeries, and the menstrual, sexual and reproductive functions. The patients underwent clinical blood analysis, urinalysis, electrocardiography and chest X-ray test, blood group and rhesus factor determination, hemostasis assay, blood analysis for RV, HIV and tumor markers, as well as transabdominal and transvaginal ultrasound using SSD-1200 and SSD-2000 devices (Aloka Ltd, Japan). We characterized the patients by the type of surgical intervention (laparoscopic or hysteroscopic), and also by age, indications for surgery, the number of fibroids and their locations, size of the uterus, presence of extragenital and genital disorders, and also by the surgery techniques. The post-surgery complication incidence rate was calculated and expressed as percentage (%), arithmetic mean (M), and standard error of the mean (m).

Results. The overall incidence of severe postoperative complications did not differ between laparoscopic (2.7 ± 0.8 %) and hysteroscopic (2.1 ± 0.8 %) operations for uterine myomas (p > 0.05). The incidence of complications was significantly higher in women operated by laparoscopy if they underwent simultaneous operations (12.3 ± 4.0 % vs. 0.6 ± 0.4 % for non-simultaneous operations), if the number of fibroids was > 4 (3.9 ± 1.4 % vs. 1.1 ± 0.8 % in those with < 4 fibroids), in the presence of anemia (8.2 ± 2.9 % vs. 1.0 ± 0.6 % in cases with no anemia), and in patients with menstruation disorders (4.9 ± 1.8 % vs. 1.3 ± 0.7 % with normal menstruation). The operated patients significantly differed by the number of uterine fibroids: the average number of fibroids was larger in those operated laparoscopically (2.9 ± 0.05 vs. 2.3 ± 0.04; p < 0.01); the proportion of patients with 4 or more fibroids was also significantly higher in those patients (53.7 ± 2.6 % vs. 30.1 ± 2.7 %; p < 0.001). The compared groups also differed in the location of their myomas.

Conclusion. The risk of postoperative complications after laparoscopic surgery is relatively high if simultaneous operations take place, if the number of fibroids is ³ 4, and in the presence of anemia or menstruation disorder.
Therapeutic significance of vitamin D and calcium in reducing the risk of preeclampsia
Authors: Vasilyeva E. N. , Maltseva L. I. , Denisova T. G. , Gerasimova L. I.
Published: July 2019

Aim: to study the possibility of reducing the incidence of preeclampsia (PE) by giving vitamin D and calcium (Ca) to pregnant women with a high PE risk starting from the second trimester of pregnancy.

Materials and methods. A total of 101 patients from the PE high risk group were examined on weeks 14–16 of pregnancy followed by treatment with vitamin D and Ca; then, the course of pregnancy and labor was analyzed. Serum 25-hydroxycholecalciferol, vitamin D binding protein, endothelin 1-38, and ionized Ca were determined using enzyme immunoassays.

Results. In the examined women at high risk of PE, severe serum deficiency of vitamin D and Ca was detected. In patients treated with vitamin D and Ca, a two-fold decrease in the incidence of PE, a three-fold decrease in the incidence of intrauterine growth retardation syndrome, and a decrease in the number of urgent surgery-assisted deliveries were found.

Conclusion. Therapy with vitamin D and Ca from the second trimester of pregnancy increases the availability of vitamin D, leads to a more favorable course of pregnancy, and prevents the development of severe forms and early onset of PE in patients at high risk.
Systematic analysis of research on D-mannose and the prospects for its use in recurrent infections of the urinary tract in women of reproductive age
Authors: Gromova O. A. , Torshin I. Yu. , Tetruashvili N. K.
Published: July 2019

Cystitis and other urinary tract infections (UTIs) in women of reproductive age can lead to infertility, significantly complicate the course of pregnancy, and cause numerous fetal abnormalities. Antibiotic therapy during pregnancy is an extreme measure since it is associated with a high risk of fetal malformations. The use of D-mannose is an effective and safe treatment for cystitis and other UTIs, especially during pregnancy. The present systematic analysis of 32111 studies indicates a significance of D-mannose for glycosylation of human proteins and for functioning of the immune, cardiovascular, urinary and other systems. By blocking the interaction between bacterial fimbriae and the endothelium, D-mannose prevents the adsorption of bacteria (uropathogenic strains of Escherichia coli, Pseudomonas aeruginosa, Shigella, leishmania, mycobacteria, etc.) to the tissue surface, thus helping prevent recurrent UTIs. Clinical studies have confirmed both high efficacy and safety of using D-mannose and the synergistic substances (such as cranberry anthocyanins) for the treatment of cystitis and other UTIs.
Ophthalmological criteria for choice of optimal mode of delivery in pregnant women with myopia
Authors: Kolenko O. V. , Sorokin E. L. , Fil A. A.
Published: July 2019

This review examines the evolution of views and opinions on issues related to the management of pregnancy and childbirth in women with high myopia. Special attention is given to the threat of retinal detachment and its prevention during pregnancy and delivery; the need for improving the diagnosis of retinal abnormalities is also addressed. Our analysis indicates that since the early 1980s, pregnancy associated peripheral vitreochorioretinal dystrophy was considered a leading risk factor for rhegmatogenous retinal detachment during childbirth. Here, we present data on the eye hemodynamics and intraocular pressure in women at the time of delivery. We also discuss current strategies of pregnancy management in women with peripheral vitreochorioretinal dystrophy. In addition, absolute and relative indications for natural delivery in women with high myopia are presented together with ophthalmological requirements for natural delivery.
Mythological roots of medical theories of gender differentiation
Authors: Koldman S. D.
Published: July 2019

Aim: to study the interrelation between the myths and the scientific understanding of sex differentiation of the fetus.

Materials and methods. The study is based on the materials published in the XIX – early XX century in Russia; among them, reports by medical professionals, ethnographers, and mystics stored in the Russian State Library, including a number of handwritten texts in the Manuscripts Department.

Results. In this review, the method of comparative historical analysis was used to reveal the predominance of the religious and mystical views in the popular understanding of sex differentiation. Among them are ideas about the right and left sides of a woman’s body, about the moral behavior of a man, about the role of the menstrual cycle in the mystical context, about the couple behavior during the intercourse, and more. Methods for predicting the sex of the future child were also reviewed, as well as the signs related to the child sex planning.

Conclusion. In the XIX – early XX century Russia, the views and understandings of obstetricians about the fetal sex differentiation were rather irrational and had no academic credibility.
ORTAOKUL VE LİSE ÖĞRENCİLERİNİN ÖĞRETMENLERE YÖNELİK GÜVEN ALGILARI
Authors: Dokumacı Sütçü Neşe , Oral Behçet
Published: July 2019

Bu araştırmada, ortaokul ve lise
öğrencilerinin öğretmenlere yönelik güven algılarını belirlemek amaçlanmıştır.
Araştırmanın çalışma grubu, 2017-2018 eğitim-öğretim yılında Diyarbakır ili
merkez ilçelerindeki okullarda öğrenim gören 185 ortaokul, 176 lise öğrencisi
olmak üzere toplam 361 öğrenciden oluşmaktadır. Araştırmada veri toplama aracı
olarak açık uçlu soru formu kullanılmıştır. Araştırmadan elde edilen verilerin çözümlenmesinde
betimsel analiz kullanılmıştır. Ortaokul ve lise öğrencilerinin görüşlerini
yansıtmak amacıyla doğrudan alıntılara yer verilmiştir. Araştırmada elde edilen
bulgulara göre, ortaokul öğrencileri güvenilir
bir öğretmende bulunması gereken nitelikler olarak toplam 33 farklı özellik
belirtmişlerdir. Ortaokul öğrencilerine göre öne çıkan nitelikler sırasıyla öğretmenlerin
öğrencilerine şiddet uygulamaması,
mesleki yeterliklerinin olması, öğrencilerine adil davranması, sevgi göstermesi, iyi insan olması, esprili/eğlenceli olması, anlayışlı/hoşgörülü ve güler
yüzlü/samimi olmasıdır. Lise
öğrencileri güvenilir bir öğretmende bulunması gereken nitelikler olarak toplam
41 farklı özellik belirtmişlerdir. Lise öğrencilerine göre öne çıkan nitelikler
ise sırasıyla öğretmenlerin öğrencilerine karşı güler yüzlü/samimi olması, öğrencilerine anlayışlı/hoşgörülü davranması, şiddet
uygulamaması, mesleki
yeterliklerinin olması,
adil davranması, öğrencilerle
iletişiminin iyi olması, yardımsever olması, öğrencilerine zaman ayırması ve dürüst olmasıdır.
‘HAYATIN BAŞLANGICI VE EVRİM’ ÜNİTESİNİN ORTAÖĞRETİM BİYOLOJİ PROGRAMINDAN ÇIKARILMASINA YÖNELİK ÖĞRETMEN GÖRÜŞLERİ: Odak Grup Görüşmesi
Authors: Önel Arzu , Derya Daşcı Arzu
Published: July 2019

‘Hayatın
Başlangıcı ve Evrim’ ünitesinin 2018 ortaöğretim biyoloji programından
çıkarılması hususunda öğretmen görüşlerinin incelenmesi amacıyla bu çalışma gerçekleştirilmiştir.
Çalışma odak grup görüşmesi şeklinde yürütülmüş ve katılımcı biyoloji
öğretmenlerine 5 ana soru yöneltilerek veriler toplanmıştır. Elde edilen veriler
nitel araştırma yöntemlerinde yer alan betimsel analiz tekniği ile
çözümlenmiştir. Çalışmanın veri seti araştırmacılar tarafından önce ayrı ayrı
analize tabi tutulmuş ardından ortaya çıkan temalar ve kategoriler karşılıklı olarak açıklanarak veri analizine son
hali verilmiştir. Katılımcı biyoloji öğretmenleri konuyu öğretmen, öğrenci ve toplumsal
açıdan değerlendirmiş, konunun programlardaki yeri ve programdan çıkarılma
nedenleri hakkında görüşler bildirmiştir.
Görüşmeden elde edilen bulgular arasında neden-sonuç ilişkisi kurularak yorumlanmış
ve katılımcı biyoloji öğretmenlerinin görüşlerinden doğrudan alıntılar
yapılmıştır.
ÜNİVERSİTE ÖĞRENCİLERİNDE SUÇLULUK KAVRAMI ÜZERİNE METAFORİK BİR İNCELEME
Authors: Dinçer Duygu
Published: July 2019

Suçluluk duygusu kendilik bilinci duygularından biridir ve kişilerarası ilişkileri düzenlemektedir. Bu çalışmanın amacı üniversite öğrencilerinin suçluluk kavramına ilişkin algılarını metafor analizi yoluyla incelemektir. Çalışmaya 278 üniversite öğrencisi katılmıştır. Elde edilen metaforlar betimsel analiz ve içerik analizi yöntemleriyle incelenmiştir. Araştırma sonuçları suçluluk duygusuna ilişkin metaforların üç tema ve on üç alt kategori altında toplandığını göstermiştir. Bu sonuçlara göre suçluluk duygusu hata yapma, norm ihlali ve olumsuz değerlendirilme durumlarında ortaya çıkmaktadır. Bu duyguya davranış ve zarar odaklı değerlendirmeler, benlik odaklı değerlendirmeler, pişmanlık, vicdan azabı ve huzursuzluk, acı çekme, zihin karmaşası, yakalanma ve ceza korkusu ve kurtulma isteği eşlik etmektedir. Son olarak, suçluluk duygusu insanları itiraf, telafi ve kalıcı iz deneyimlemeye sevk etmektedir. Araştırma bulguları ilgili alanyazın ışığında tartışılmıştır.
TÜRKÇE EĞİTİMİ ANABİLİM DALI ÖĞRENCİLERİNİN DİLEKÇE YAZMA YETERLİKLERİ
Authors: Örge Yaşar Funda , Gümüşkaya Tuğba
Published: July 2019

Dilekçeler,
herhangi bir istekte bulunmak ya da bir durumu şikâyet etmek amacıyla yazılan
ve günlük hayatta en sık karşılaşılan resmi yazılardandır. Bu çalışma,
branşları gereği öğrencilerine dilekçe yazma becerisini kazandıracak Türkçe
öğretmeni adaylarının dilekçe yazarken yaptıkları yanlışları belirlemek,
yanlışların ağırlıklı olarak biçim özelliklerinden mi yoksa içerik
özelliklerinden mi kaynaklandığını tespit etmek amacıyla yapılmıştır. Çalışmada
ayrıca, yapılan hataların sınıflara ve cinsiyete göre farklılık gösterip
göstermediği de incelenmiştir. Bu bağlamda, çalışmada Türkçe öğretmen
adaylarının yazdıkları örnek dilekçelerden hareketle yaptıkları yanlışları
belirlemek amacıyla nitel araştırma yöntemlerinden biri olan doküman incelemesi
kullanılmıştır. Çalışmanın evren ve örneklemini Çanakkale Onsekiz Mart
Üniversitesi Türkçe ve Sosyal Bilimler Eğitimi Bölümü Türkçe Eğitimi Anabilim
Dalında öğrenim gören 1, 2, 3 ve 4. sınıf öğrencileri oluşturmaktadır. Veriler,
Türkçe öğretmen adaylarına yazdırılan dilekçe metinlerinden elde edilmiştir.
Türkçe öğretmen adaylarının en az hatayı tarih yazma ve meramını anlatma, en
fazla hatayı ise makam adını yazmada, kendini tanıtmada ve istek cümlesinde
yaptıkları tespit edilmiştir. Çalışmanın sonunda elde edilen verilerden
hareketle alan yazındaki diğer çalışmalarla karşılaştırmalar yapılmış ve
önerilerde bulunulmuştur.
OKULLARDA HAYAT BOYU ÖĞRENME YETERLİLİKLERİ: NİTEL BİR DURUM ÇALIŞMASI
Authors: Doğan Soner , Çalışkan Toyoğlu Ayşe
Published: July 2019

Bu
araştırmanın amacı devlet okullarında görev yapan öğretmenlerin hayat boyu
öğrenme yeterliliklerine ilişkin görüşlerini belirlemektedir. Araştırma nitel
bir durum çalışmasıdır. Çalışma grubunu Sivas il merkezinde görev yapan 479
öğretmen oluşturmaktadır. Veri toplama sürecinde araştırmanın amacına yönelik
olarak çalışma grubunda yer alan öğretmenlere yüz yüze görüşme yaparak bilgi
verilmiş, daha sonra öğretmenlerden yarı yapılandırılmış görüşme formunu yazılı
olarak doldurmaları istenmiştir. Yarı yapılandırılmış görüşme formu Avrupa
birliği tarafından belirlenen 6 hayat boyu öğrenme yeterliliğinden oluşmaktadır.
Uygulama sonucu 433 öğretmenden dönüş sağlanmış ve elde edilen veriler içerik
ve betimsel analiz yöntemiyle değerlendirilmiştir. Araştırma bulgularına göre
katılımcılar, hayat boyu öğrenme yeterlilikleri olan anadilde iletişim
yeterlikleri, yabancı dilde iletişim yeterlikleri, matematiksel ve
bilim-teknolojide temel yeterlikler, dijital yeterlikler, öğrenmeyi öğrenme
yeterlikleri, girişimcilik yeterlikleri ile ilgili olarak genellikle olumlu
görüşler belirtmişlerdir. Ancak özellikle okulların fiziki yetersizliklerine,
okul paydaşlarının ilgisizliğine ve hayat boyu öğrenme kavramının yeterince
anlaşılamamasına bağlı olarak olumsuz görüşlerde ortaya çıkmıştır.
On Affective States and the Use of Affect in DIR Floortime Clinical Practice
Authors: Itskovich G.
Published: July 2019

The leading role of affect became the premise of DIRFloortime. Ideas of S. Greenspan are confirmed by S. Porges who sees affective experience as driving force of the evolutionary process. Incidentally, children on the autistic spectrum operate within a limited repertoire of explicit emotions; it is the lack of affective expression that usually gets in a way of building meaningful connections. However, therapeutically sound range of affective initiations and responses has been studied very little. This paper examines the definition of affect within DIRFloortime framework, as compared to more conventional, albeit controversial, use of this term in the psychiatric practice. It is expected of a seasoned DIR provider to be able to identify his or her own affective state and corresponding mood fluctuations, to make use of interoceptive messages, and eventually, in the course of the therapeutic intervention, adjust it as s/he goes. In order to achieve these goals, one needs to develop working knowledge of the recent theories of neuroception, namely, polyvagal response and its link to affective experiences. Affective states, their types and intensity, need to be tailored down to meet and modulate the child’s affect; this paves the road to designing effective intervention plans. The path to effective affect modulation starts with the provider’s self-awareness. Practical considerations and strategies are discussed.
Model of Imposed Adaptation in Childhood Learning Environments — Application to Autism. A precarious game of developmental Jenga
Authors: Spielmann V. , Porter L.
Published: July 2019

Academic and social expectations place ever-increasing stressors on young children. The failings of our academic system to address these concerns greatly impact the general population but may be even more harmful for children on the autism spectrum, who are shown to have significantly higher rates of anxiety, depression, and suicide in later life. The relational and ecological demands indiscriminately placed on autistic children to achieve one-size-fits-all academic learning goals is examined in this paper, along with current evidence exploring the risks faced by autistic youth. Sensory Integration theory posits that brain development and function are driven by actions of the environment upon an organism, and correspondingly the reactions of that same organism on the environment. This notion, an important principle of pediatric occupational therapy, fits within a
dynamic systems approach to child development, where environment, relationship, neurobiology and genetics co-act and self-organize through dynamically sustained states. An idea foundational to the proposed model in this paper. We will explore this model using the analogy of Jenga towers to discuss some of the hazards that a reductionist approach to education pose to child development. Finally, questions are asked regarding the implications of these adaptive responses from the perspective of dynamic systems theory.
The DIRFloortime Approach in Speech Therapy for Speech Development in Children with ADs and Other Disorders. Recommendations for Parents and Teachers
Authors: Gomozova E.S. , Gomozova M.A.
Published: July 2019

The “RecheTsvetik” center offers an intervention program based on the DIRFloortime developmental approach for speech development in children with autism spectrum disorders. The main rule when working with a child is to help him learn how to use ideas and words and to associate words and ideas of a parent or a teacher with his own desires and intentions. This article provides recommendations and techniques used by DIR speech therapists to develop speech in children with autism spectrum disorders and is intended for parents and teachers.
Neuropsychologist’s Experience with the DIRFloortime Concept. A Clinical Case Report
Authors: Shishkina S.A.
Published: July 2019

The article analyzes the experience of the joint work of a speech therapist and a neuropsychologist using the DIRFloortime concept on a clinical case of a boy L., 3.5 years of age. The following tasks were solved during the sessions: the child’s advancement along the first stages of functional emotional development, taking into account his individual characteristics; work with the family: establishing a partnership, teaching the family members the basics of the DIRFloortime approach. As a result of the sessions, the child’s understanding of speech and implementation of instructions have significantly improved; he started using meaningful words and phrases for communication; his emotional and non-verbal repertoire expanded, the boy learned to play simple games with rules with an adult.
Why the process is so Important for a DIRFloortime specialist
Authors: Naidina I.V.
Published: July 2019

DIRFloortime® is a learning approach tailored to individual characteristics of the adult and child and based on establishing emotionally charged relationships, which is successfully used to help children with autistic spectrum disorders. An expert trained in DIRFloortime® offers her thoughts on the importance of the interaction process between children and adults during sessions and in the real-life setting. The paper reviews following the child’s lead and challenging — the main strategies of the DIRFloortime approach. It describes the concept of the circle of communication and characteristics of the interaction process, such as tempo, rhythm, duration, intensity, and content. The process of interaction with children affected by autistic spectrum disorder who have difficulties in communicating should be arranged so that they can be engaged and remain in this process with pleasure and joy as long as possible. The child must feel successful and valuable in the eyes of adults who help him/her grow up. Then the child will be able to cope with his fears, shyness, perceptual and motor challenges and to grow in a most harmonious way. This is why DIRFloortime creators and therapists give particular importance to the process of interaction.
Results of the International Scientific-Practical Conference Innovations in Autism Interventions: Research and Practice of DIRFloortime®
Authors: Razukhina E.V.
Published: July 2019

The purpose of the International Scientific-Practical Conference Innovations in Autism Interventions: Research and Practice of DIRFloortime® is to share the experience of helping children with ASD using the DIRFloortime® model. This article describes the conference results and its significance for dissemination of modern technologies and various approaches to helping children with autism in Russia: 425 professionals and parents from 32 constituent entities of the Russian Federation and 6 foreign countries took part in this conference, 357 of them received certificates confirming the DIR 101 course training.
The Study of the Reservoir Inter-architecture Structure and Remaining Oil in the Eastern Part of Sabei II District
Authors: Wei Huabin , Zhu Huanlai , Li Hengshuang , Shi Shangming , Gan Senlin , Zhai Zhiwei
Published: July 2019

In the Daqing oilﬁeld, Heilongjiang Province, China, in the eastern part of the Sabei II District is a ﬁ ne potential-tapping demonstration area with a long development time and complex history of well conditions. As oil exploration has entered into the high-water cut stage, the ﬁne description of reservoir structure had a great signiﬁcance to improve the eﬀect of oil exploration. An abandoned channel is an important basis for recognizing a single river border and point bar. The top sand-shale interbedded or muddy sediments have a shelter action for the reservoir ﬂuid, so correctly recognizing the abandoned channel is an important scientiﬁc basis for further analysing reservoir architecture and exploring the remaining oil. Due to the lateral shelter action of sand-shale interbedded with muddy sediments, the semi-connected body, consisting of abandoned and normal channel sand body, leads to an injection and production imbalance, which is namely production without injection or injection without production. It makes the top of the channel sand body become the favourable gathering place for remaining oil and a further main exploring object.
Conceptual development of the transition from drill and blast excavation to non-blasting methods for the preparation of mined rock in surface mining
Authors: Sobko Boris , Lozhnikov Oleksii , Levytskyi Volodymyr , Skyba Galyna
Published: July 2019

This article is devoted to the conceptual development of the transition from drill and blast excavation to a non-blasting method for the preparation of hard rock before excavation at construction material deposits. The scientiﬁc and technical literature on the problems in the blasting of hard rock in preparation for excavation is analysed. A classiﬁcation of mining equipment for the non-blasting development of a rock mass for excavation has been developed, taking into account the nature of the operation of mining equipment. The concept of the transition from drill and blast excavation to nonblasting methods in the preparation of mined rock in non-metallic material quarries is presented. The research results of the parameter determination of the elements of the system for the development of non-blasting equipment at a limestone quarry are presented. The economic eﬃciency of a hydraulic excavator with a ripper tooth for developing limestone with a strength of up to 30 MPa is established.
Application of machine learning models in predicting initial gas production rate from tight gas reservoirs
Authors: Amaechi Ugwumba Chrisangelo , Ikpeka Princewill Maduabuchi , Xianlin Ma , Ugwu Johnson Obunwa
Published: July 2019

Driven by advancements in technology, tight-gas ﬁeld development has become a signiﬁcant source of hydrocarbon to the energy industry. The amount of data generated in the process is immense as most platforms are now being digitized. Machine learning tools can be used to analyse this data in order to build patterns between several dependent and independent variables. Forecasting initial gas production rates has important implications in the planning production/processing facilities for new wells, aﬀects investment decisions and is an important component of reporting to regulatory agencies. This study is based on the analysis of reservoir rock/ﬂuid properties and selected well parameters to build decision-based models that can predict initial gas production rates for tight gas formations. In this study, two machine learning predictive models; Artiﬁcial Neural Network (ANN) and Generalized Linear Model (GLM), were used to determine the expected recovery rate of planned new wells. Production data was retrieved from 224 wells and used in developing the model. The results obtained from these models were then compared to the actual recorded initial gas production rate from the wells. Results from the analysis carried out revealed a Mean Square Error (MSE) of 1.57 on a GLM model whereas the ANN model gave an MSE of 1.24. Key Performance Index for the ANN model revealed that reservoir thickness had the highest (36.5%) contribution to the initial gas production rate followed by the ﬂowback rate (29%). The reservoir/ﬂuid properties contribution to the initial gas production rate was 53% while the hydraulic fracture parameters contribution to the initial gas production rate was 47%.
Evaluation of the spontaneous combustion of coal (SCC) by using the R70 test method based on the correlation among intrinsic coal properties (Case study: Tabas Parvadeh coal mines, Iran)
Authors: Saﬀari Amir , Ataei Mohammad , Sereshki Farhang
Published: July 2019

The purpose of this research is to perform an evaluation of the spontaneous combustion of coal (SCC) in Tabas Parvadeh coal mines in Iran, by using the R70 test method based on the correlation between intrinsic coal properties and the occurrence of its combustion. Firstly, the coal samples were collected from Parvadeh I to IV, and the intrinsic coal properties of the samples were tested. Then, the R70 test method, as the newest method for assessment of the SCC, was used. In the last step, the correlation between intrinsic coal properties and R70 test values was carried out. The results showed that the B1 seam in Parvadeh II and the C1 seam in Parvadeh III have a high propensity of the SCC. The outcomes appear, an expansion of moisture, pyrite, vitrinite, and liptinite contents enhance the SCC tendency in these mines. The results obtained have major outcomes for the management of this phenomenon in Tabas Parvadeh coal mines.
Examination of the role of moisture content on the spontaneous combustion of coal (SCC)
Authors: Saﬀari Amir , Ataei Mohammad , Sereshki Farhang
Published: July 2019

The percentage of moisture content is one of coal’s inherent characteristics, which has a crucial aspect in the occurrence of the spontaneous combustion of coal (SCC) and has long been an attractive issue for analysis among scientists. A complete understanding of this phenomenon helps experts in the prediction and prevention of its occurrence. For this reason, the present work predicts this phenomenon based on moisture content. Thus, a ﬁnal conclusion about the eﬀect of this parameter was determined. Fifty-one coal samples with diﬀerent percentages of moisture content were collected from underground coal ﬁelds in Iran for the practice training and testing of crossing point temperature (CPT) and R70 test methods. Then, the method of regression analysis was used for modelling and predicting the SCC tendency. The results showed that coal samples were oxidized most rapidly when the moisture content supply was under 20%, and it can reduce the prevalence of the SCC in situations when the moisture was in excess of 20% because the heat released by oxidation is used to evaporate the moisture. For validation and testing, 13 coal samples of another coalﬁeld were collected and CPT and R70 test methods were carried out. The results of the test methods were compared through regression equations. The results obtained from the models indicate a good appropriate prediction in terms of the determination of the SCC tendency by regression analysis.
Recovery of waste expanded polystyrene in lightweight concrete production
Authors: Bedeković Gordan , Grčić Ivana , Anić Vučinić Aleksandra , Premur Vitomir
Published: July 2019

Polystyrene concrete, as a type of lightweight aggregate concrete, has been used in civil construction for years. The use of waste expanded polystyrene (EPS) as a ﬁll material in lightweight concrete production is highly recommended from the point of view of the circular economy. Published data shows that an increase in the proportion of lightweight aggregates, i.e. EPS, results in a decrease in strength, bulk density and thermal conductivity of the concrete. Utilizing large quantities of waste EPS in non-structural polystyrene concrete production is particularly important. Unlike structural polystyrene concrete, according to the published papers, non-structural polystyrene concrete has not been investigated suﬃciently. The purpose of this paper is to determine the inﬂuence of the ratios of the basic components in a concrete mixture on the bulk density and compressive strength of non-structural polystyrene concrete produced by utilizing waste EPS as a ﬁll material. The test specimens, i.e. cubes with an edge length of 100 mm each, were prepared in laboratory conditions by varying the proportions of EPS, sand up to 600 g and cement ranging from 300 g to 450 g per specimen. Bulk density and compressive strength were determined for the test specimens. Laboratory research results show a dependence of the component ratio on the bulk density ranging from 360 kg/m3 to 915 kg/m3 and compressive strength ranging from 0.385 MPa to 2.538 MPa.
An image-based method to determine the particle size distribution (PSD) of fine-grained soil
Authors: Tabrizi-Zarringhabaei Saman , Ejlali Reza Goli , Fard Mikaeil Yousefzadeh , Sayyedfattahi Sayyedjavad
Published: July 2019

This paper discusses the PSD eﬀects on the behavior of soil and its properties. The coarse grain part of soil can be analyzed with sieve analysis. Evaluating the PSD of ﬁ ne-grained soil with the traditional method (hydrometer analysis) is a time-consuming process, has laboratory complexities and the obtained results are not accurate. Due to these limitations, there is a demand for a method that can oﬀer faster data with more accuracy for geotechnical engineering. In this paper, the digital image processing (DIP) method is proposed using microscopic images and MATLAB software to determine the PSD of ﬁne-grained soil. The DIP method was compared with the hydrometer analysis. The analysis of the data obtained from these two methods indicated that the image based method is capable of providing faster and more comprehensive results of the PSD.
A Case of Fingernail Onychomycosis Caused by Fusarium proliferatum
Authors: Hong Eun Hye , Jang Ye Ji , Cho Eun Byul , Park Eun Joo , Kim Kwang Joong , Kim Kwang Ho
Published: July 2019

Onychomycosis is a fungal nail infection caused mainly by dermatophytes. Non-dermatophytes such as yeasts, Acremonium, Aspergillus, and Fusarium species account for only 10% of onychomycosis, and Fusarium species are relatively common amongst these pathogens. However, the main Fusarium species pathogens are Fusarium solani and Fusarium oxysporum. Fusarium proliferatum is a rare pathogen in onychomycosis, and only a few cases have been reported worldwide. We report a case of a 68-year-old woman presenting with a white- to yellow-colored patch on her left third fingernail plate, which was diagnosed by fungus culture and sequencing as onychomycosis caused by Fusarium proliferatum.
Organizational and Economic Aspects of the State Support of the Enterprises and Organizations of National Defense Industry
Authors: Mishin Y. V.
Published: July 2019

Purpose: the purpose of the work is to prepare reasonable proposals for the development of state support for investment activities – programs of diversification of enterprises and organizations of the defense industry. The relevance of the topic of this article is because the current state support mechanisms do not effectively stimulate the implementation of projects to diversify enterprises and defense industry organizations. Therefore, it is necessary to develop special regulatory documents that take into account the specific features of the organization of production and production of defense-industrial complex (first of all, the “State program for diversification of enterprises and defense-industrial complex organizations”) for a rather long period of time.

Methods: the methodological basis of the work is the dialectical method of scientific knowledge, as well as systemic and institutional approaches. In the course of the study, the procedures and instruments of state support for investment activities of business entities used methods of analysis and synthesis, comparison and analogies. The methodological basis of this article was legal documents in the field of investment promotion (Decrees of the President of the Russian Federation, Decrees of the Government of the Russian Federation, orders of ministries, etc.).

Results: the article formulates proposals on the methods and procedures of justifying calculations, as well as the procedure and conditions for the provision of target funds. The proposals were developed on the basis of the analysis of the specific features of the organization of production and military products manufactured by the defense industry, as well as existing legal documents in the field of state support for investment activities.

Conclusions and Relevance: аt the present stage of development of the Russian economy, the state must not only provide support to enterprises and organizations of the defense industrial complex in the form of concessional loans, subsidize interest rates on them, but also finance research and development costs from the federal budget. It should create interest among potential buyers in their acquisition of civilian products not only by economic, but also by administrative methods. At the same time, projects should be evaluated according to three criteria: the level of competitiveness of products in the world markets, commercial (financial) and budgetary efficiency.
Small and Medium Enterprises in the Russian Transaction Sector
Authors: Gurova I. M.
Published: July 2019

Purpose: to study the significance of small and medium enterprises for the functioning of the modern Russian transaction sector.

Methods: the paper used General scientific research methods: analysis and synthesis, abstraction, generalization. The study used a comparative method and elements of economic analysis. The article also uses a graphical method of presenting information. The study was carried out on the basis of official statistical data provided by the Federal State Statistics Service of Russia.

Results: to achieve this goal, the article solves the following tasks: 1) A review analysis of the current state of the domestic transaction sector based on the study of statistical data on the activities of Russian enterprises and organizations. This formed the basis for further research. 2) Analyzed indicators of small and medium enterprises in the transaction types of economic activity. This made it possible to identify their role in the functioning of the transaction sector. 3) Studied the statistical indicators of the financial condition of small and medium organizations of the transaction sector, which showed the problems of their activities.

Conclusions and Relevance: currently, the transaction sector is a significant part of the domestic economy. This is evidenced by a General analysis of the statistical characteristics of the activities of Russian enterprises and organizations. At the same time, the majority of enterprises engaged in transactional activities have a private form of ownership. The study of the activities of small and medium enterprises showed that today more than half of them work in the transaction areas. In this regard, small and medium businesses can be considered an integral and very important part of the modern transaction sector. The flagship of the transactional activity in the business environment is small businesses. Their indicators significantly exceed the corresponding values of medium organizations. In addition, the main role of small enterprises is due to the immanent properties of small-scale companies. Nevertheless, the analysis of indicators of the financial condition of small and medium enterprises of transaction activities revealed their weak business and commercial efficiency, the presence of problems of solvency and financial stability. This threatens not only the viability of enterprises, but also the efficient functioning of the transactional sector. In this regard, there is a need to develop and conduct systemic activities aimed at supporting the development of Russian small and medium enterprises, as well as stimulating the development of the entire domestic transaction sector, consistent with the general strategy of economic development of Russia.
Modeling a Process-Oriented System for Ensuring the Guality of Medical Services in the Arctic zone of the Russian Federation
Authors: Glazov K. N.
Published: July 2019

Purpose: the main goal is to simulate a process-oriented system for ensuring the quality of medical services in health care facilities in the Arctic zone of the Russian Federation. To achieve this goal, the following tasks were solved: formulated the main aspects of process-oriented quality assurance services in health care; a model was built for the implementation of a process-oriented system for ensuring the quality of services in the conditions of the Arctic territories; developed guidelines for the practical implementation of a process-oriented system to ensure the quality of medical services in the Arctic regions of the Russian Federation.

Methods: this article is based on an interdisciplinary concept of ensuring the quality of medical services provided in relation to the specifics of the functioning and development of treatment-and-prophylactic organizations based on a process-oriented approach.

Results: the most important direction of development of the national economy is to ensure an adequate level of quality of medical services provided in health care organizations and in the formation of patient-oriented service for end users (patients), which is especially important for the Arctic zone of the Russian Federation. The article analyzes foreign sources regarding the use of a process-oriented approach to the issues of ensuring the quality of medical services provided. Also in this publication a model of process-oriented quality assurance of medical services in the conditions of the Arctic territories of the Russian Federation is formed. Practical recommendations for the effective use of process-oriented mechanisms ensuring the quality of medical services in the Arctic regions of the Russian Federation have been developed.

Conclusions and Relevance: the materials presented in the article show the special role of the health care system in social and economic processes. The proposed model of ensuring the quality of medical services is recommended for use not only in the represented region, it could be effective for all organizations in the field of health care, regardless of the form of ownership and organizational-legal form, as well as territorial location. Research conducted in this article represents the development of scientific ideas about modern technologies to ensure the quality of medical services in a regional perspective. The practical application of its results will improve the procedures for managing the quality of services, organizing business processes of basic medical activities, including the production of medical services, as well as their service characteristics in relation to healthcare, taking into account current economic and social trends, and as a result ensure their sustainable development.
Threats of hostile takeover in context of the business economic security
Authors: Margolin A. M. , Vyakina I. V.
Published: July 2019

Purpose: the article contains critical analysis and scientific review of research in the field of mergers and takeovers in the world academic literature and identifies the key factors causing the probability of losing a business in terms of business security in modern conditions of economic relations transformation. The following tasks have solved in the article to achieve this goal: scientific review and classification of academic studies on the problem of hostile takeovers in the interdisciplinary aspect of economic security have performed; key endogenous and exogenous factors that determine the threat of seizing business and the mechanisms for its protection against hostile takeovers have identified; possibilities of applying international experience in protecting against hostile takeovers under Russian conditions have analyzed.

Methods: the article uses a set of scientific methods for analyzing literary sources and statistical data, among which are: methods of induction and deduction, logical abstraction, causal, functional, system, historical and comparative analysis, etc.

Results: authors have identified endogenous and exogenous factors that increase the likelihood of hostile takeover, and have analyzed the impact of legislation and regulations on the activity of mergers and acquisitions in Russia and the world. The scientific review carried out by the authors is positioned in the existing set of studies and sets the directions for future research in the field of the economic security of business that are necessary for understanding this phenomenon.

Conclusions and Relevance: Russian and foreign studies in the field of mergers and acquisitions differ in the methods and form used to substantiate the findings and results of research. The problems of business security and protection against hostile takeovers have interdisciplinary nature, while the threats of hostile takeovers can be both external and internal. Improving the legal framework along with economic mechanisms will allow creating conditions for protecting the interests of investors, enhancing business activity and business efficiency. The measures used in world practice for protection against hostile takeovers are of limited use in Russia due to the relative youth of the phenomenon itself and the domestic capital market, as well as due to the specifics of Russian legislation. In this regard, it is necessary to continue further research in this sphere.
Integrated Management of Innovative Development of the Region on the basis of Scenariated Approach
Authors: Uandykova M. K.
Published: July 2019

Purpose: the aim of the work is to study the problems of innovative development of the Republic of Kazakhstan and its regions, to consider the management of innovative development of regions on the basis of integrated management (sharing project and scenario approaches).

Methods: the methods of system analysis, the concept of system-integrated management, including the combined use of project and system approaches, outlined the methodological outline of the study.

Results: the proposed theoretical and methodological approaches to the management of innovative development of the region; considered the concept of project management of the region, made the transition from consideration of the economy itself to a complex of state programs for their development, taken as an interconnected system. The state programs themselves are considered as a set of projects (programs). Further it is proposed to use scenario management for their analysis and implementation. A cybernetic model of the region's innovative development management system is proposed.

Conclusions and Relevance: to manage the innovative development of the country and its regions, it is possible and necessary to use the transition and system management of a complex of strategic and planned development programs of the country and its regions, which are an integrated system of interrelated documents. The cybernetic model of the region's innovative development management system allows making a transition to using an integral approach of sharing scenario and project management in system modeling of the formation and implementation of IRR programs and effectively selecting management solutions for the further implementation of development programs (projects).