bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance evaluation of an automatic resonant switched capacitor-based voltage balancing circuits for series connected batteries
Authors: Hafiz Samsul , Wijaya Sastra Kusuma , Kurniawan Edi
Published: July 2024

Electrical energy storage (EES) plays a crucial role in various power applications. Voltage imbalance is a common issue that can negatively affect the efficiency, reliability, and safety of EESs. Several types of voltage balancing (VB) circuits have been proposed in much of the literature. Among these VB circuits, switched capacitor (SC)-based circuits have attracted significant interest due to their efficiency, cost-effectiveness, compact size, and ease of control, but their balancing performance is not yet satisfactory. As a result, structural modifications in SC-based circuits have been widely proposed to improve balancing performance. However, not all of these circuit structures have been implemented into a resonant switched capacitor (RSC)-based voltage balancing, which has higher efficiency. Hence, this study aims to assess the efficiency of RSC-based VB circuits by conducting analog simulation using the Matlab Simulink software. This research evaluates the performance of the VB circuit not only in terms of its speed and efficiency, but also in terms of its energy distribution. The results show that the delta structure is the fastest in terms of balancing speed when completing the balancing process, followed by the mesh structure and the parallel structure. The best energy distribution is produced by a parallel structure, as indicated by the change in voltage of all battery cells always moving towards a convergent value, regardless of the variations in initial imbalance conditions. Meanwhile, other circuit structures distribute energy randomly, allowing the voltage of the battery cells to change not directly towards a convergent value. Lastly, the paper summarizes the balancing speed, efficiency, circuit complexity, and quality of energy distribution.
Uncertain vibration response of vehicles passing through barricades based on approximate models
Authors: Sun Lijuan , Wang Minjun
Published: July 2024

In vibration analysis, a vehicle system encounters dimensionality issues due to its high-dimensional uncertain parameters. An approximate model offers a viable solution for analyzing such uncertain responses. This study introduces an efficient approximate model, called PCE-HDMR, which is founded on the Legendre Polynomial Chaos Expansion (PCE) and High-Dimensional Model Representation (HDMR). Specifically, the Legendre PCE in interval space is employed to delineate the lower and upper bounds of uncertain responses. At the same time, the HDMR is harnessed to develop a high-dimensional uncertainty model that approximates the dynamic response. To demonstrate the application of PCE-HDMR, a model for a vehicle with interval parameters was constructed using a 9-DOF dynamics model for testing. In this framework, all stiffness and damping parameters are treated as interval uncertainty parameters. The numerical results validate the effectiveness of the proposed method for high-dimensional uncertain parameters, demonstrating that PCE-HDMR outperforms Monte Carlo simulation (MCS) in terms of efficiency. This study advances an effective interval uncertainty analysis approach for assessing vehicle performance, particularly when dealing with high-dimensional interval uncertainty parameters. The proposed method serves as a viable alternative for interval analysis and subsequent optimization design for complex vehicle systems characterized by high-dimensional uncertain parameters.
Silk fibroin-based flexible pressure sensors: processing and application
Authors: Chen Muhan , Liu Junhong , Hu Yidi , Wu Yujie , Tang Chun-Yan , Ke Kai , Yang Wei
Published: July 2024

With the advent of the internet of things and artificial intelligence, flexible and portable pressure sensors have shown great application potential in human-computer interaction, personalized medicine and other fields. By comparison with traditional inorganic materials, flexible polymeric materials conformable to the human body are more suitable for the fabrication of wearable pressure sensors. Given the consumption of a huge amount of flexible wearable electronics in near future, it is necessary to turn their attention to biodegradable polymers for the fabrication of flexible pressure sensors toward the development requirement of green and sustainable electronics. In this paper, the structure and properties of silk fibroin (SF) are introduced, and the source and research progress of the piezoelectric properties of SF are systematically discussed. In addition, this paper summarizes the advance in the studies on SF-based capacitive, resistive, triboelectric, and piezoelectric sensors reported in recent years, and focuses on their fabrication methods and applications. Finally, this paper also puts forward the future development trend of high-efficiency fabrication and corresponding application of SF-based piezoelectric sensors. It offers new insights into the design and fabrication of green and biodegradable bioelectronics for in vitro and in vivo sensing applications.
Trends in endometrial cancer incidence in the United States by race/ethnicity and age of onset from 2000 to 2019
Authors: Rodriguez Victoria E , Tanjasiri Sora Park , Ro Annie , Hoyt Michael A , Bristow Robert E , LeBrón Alana M W
Published: July 2024

Endometrial cancer is one of few cancers that has continued to rise in incidence over the past decade, with disproportionate increases in adults younger than 50 years old. We used data from the Surveillance, Epidemiology, and End Results Registry (2000-2019) to examine endometrial cancer incidence trends by race/ethnicity and age of onset among women in the United States. Case counts and proportions, age-adjusted incidence rates (per 100 000), and average annual percent changes were calculated by race/ethnicity, overall and stratified by age of onset (early vs late). We found a disproportionate increase in endometrial cancer incidence among women of color, for both early and late onset endometrial cancer. The highest increases in early onset endometrial cancer (<50 years old) were observed among American Indian/Alaska Native women (4.8), followed by Black (3.3), Hispanic/Latina (3.1), and Asian and Pacific Islander women (2.4), whereas White women (0.9) had the lowest increase. Late onset (≥50 years old) endometrial cancer incidence followed a similar pattern, with the greatest increases for women of color. The increasing burden of endometrial cancer among women of color, particularly those younger than 50 years old, is a major public health problem necessitating further research and clinical efforts focused on health equity.

This article is part of a Special Collection on Gynecological Cancer.
From transthyretin cardiac amyloidosis diagnosis to tafamidis treatment: Association of drop-off with patient sociodemographic characteristics
Authors: Walenczyk Kristie M , Singh Avinainder , Tong Kimhouy , Burg Matthew M , Miller Edward J
Published: July 2024

Purpose

Compared to estimated population prevalence rates, relatively few patients at risk are diagnosed with and treated for transthyretin cardiac amyloidosis (ATTR-CA). Where along the clinical pathway patient drop-off occurs, as well as the association of drop-off with patient sociodemographic characteristics, remains unknown.

Methods

Using data from a healthcare system–wide cardiovascular imaging repository and specialty pharmacy, we characterized the clinical pathway from diagnosis with pyrophosphate scintigraphy (PYP) to tafamidis prescription, initiation, and adherence. Standardized differences (d values of ≥0.20, indicating at least a small effect size) were used to compare sociodemographics (age, sex, race, Area Deprivation Index) among patients with PYP-identified ATTR-CA by tafamidis prescription status and among patients prescribed tafamidis by initiation status. Tafamidis adherence was measured with the proportion of days covered (PDC).

Results

Of 97 patients with ATTR-CA, 58.8% were prescribed tafamidis, with 80.7% of those initiating therapy. Patients with ATTR-CA prescribed tafamidis were younger than those not prescribed tafamidis (d = –0.30). Utilization of a specialty pharmacy resulted in enrichment of treatment in subgroups traditionally undertreated in cardiovascular medicine, with higher rates of tafamidis initiation among women (100% initiation), patients of Black/African American race (d = 0.40), and those living in more economically disadvantaged areas (d ≥ 0.30). Adherence was high (PDC of >80%) in 88.4% of those initiating tafamidis.

Conclusion

These findings highlight the tremendous opportunity for more robust ATTR-CA clinical programs, identifying potential patient subgroups that should be targeted to reduce disparities. For patients diagnosed with ATTR-CA, utilization of a specialty pharmacy process appears to ensure equitable provision of tafamidis therapy.
Influence of visual information on sniffing behavior in a routinely trichromatic primate
Authors: Weiß Brigitte M , Widdig Anja
Published: July 2024

Most catarrhine primates are considered to be strongly visually oriented, obtaining information about conspecifics and their environment from a diversity of visual cues. Other sensory modalities may provide information that is redundant and/or complimentary to visual cues. When cues from multiple sensory modalities are available, these may reinforce or suppress each other, as shown in several taxa ranging from insects to humans. Here, we tested how the presence and ambiguity of visual information affect the use of olfactory cues when exploring food and non-food items in semi-free-ranging Barbary macaques at Affenberg Salem, Germany. We presented monkeys with pipes containing food (peanuts, popcorn), non-food (stones, feces), or no items in transparent or opaque containers and assessed whether animals looked, sniffed, and/or grabbed into the pipes depending on the visibility of the contents (experiment 1). Visual information had no robust effect on sniffing probability, but monkeys were more likely to sniff before any other form of inspection if the can was opaque than if it was transparent. Both visual and olfactory information affected, whether or not monkeys attempted to retrieve the items from the pipes, whereby monkeys showed an overall decrease in the propensity to grab after sniffing. Furthermore, we manipulated the visual appearance of familiar food items (popcorn) with food colorant (experiment 2), which resulted in substantially increased olfactory inspections compared to unmanipulated popcorn. Taken together, reliance on the olfactory sense was modulated by the available visual information, emphasizing the interplay between different sensory modalities for obtaining information about the environment.
Antibody design using deep learning: from sequence and structure design to affinity maturation
Authors: Joubbi Sara , Micheli Alessio , Milazzo Paolo , Maccari Giuseppe , Ciano Giorgio , Cardamone Dario , Medini Duccio
Published: July 2024

Deep learning has achieved impressive results in various fields such as computer vision and natural language processing, making it a powerful tool in biology. Its applications now encompass cellular image classification, genomic studies and drug discovery. While drug development traditionally focused deep learning applications on small molecules, recent innovations have incorporated it in the discovery and development of biological molecules, particularly antibodies. Researchers have devised novel techniques to streamline antibody development, combining in vitro and in silico methods. In particular, computational power expedites lead candidate generation, scaling and potential antibody development against complex antigens. This survey highlights significant advancements in protein design and optimization, specifically focusing on antibodies. This includes various aspects such as design, folding, antibody–antigen interactions docking and affinity maturation.
Expert perspective on technological choice for cooking energy transition in Nepal
Authors: KC Dipesh , Lohani Sunil Prasad , Shrestha Poushan , Xue Chunyu
Published: July 2024

Solid biomass dominates as the primary source of cooking energy, especially in rural households of Nepal. The use of solid biomass has a detrimental effect on health, exacerbates the burden of biomass collection, and hampers access to clean energy. Understanding the factors influencing the choice of modern cooking fuels is crucial to improving energy security and resilience and easing the transition to clean fuels. This study evaluates technological choices for the transition in cooking energy from the perspective of experts working in the government, non-government, and academia sectors. A structured questionnaire survey was prepared with five criteria and nine cooking technology options. Fifty-one experts responded to the survey, and their responses were analyzed using the analytical hierarchy process. The study reveals that efficiency and capital cost are the primary criteria for selecting cooking technology. The most suitable clean cooking technology is an induction stove followed by a hot plate, while the least preferred technology is a Bayupankhi stove followed by two-pothole mud improved cooking stoves. To ensure the robustness of the method, sensitivity analysis was performed on the two primary criteria efficiency and capital cost of the cooking technology. The analysis revealed robust and consistent rankings of technologies. This study should help create a conducive environment for relevant stakeholders and policymakers to formulate and implement relevant policies and strategies to accelerate the cooking energy transition in Nepal.
Informal Incentives and Labour Markets
Authors: Fahn Matthias , Murooka Takeshi
Published: July 2024

This paper investigates how labour-market tightness affects market outcomes if firms use informal, self-enforcing, agreements to motivate workers. We characterise profit-maximising equilibria and show that an increase in the supply of homogeneous workers can increase wages. Moreover, even though all workers are identical in terms of skills or productivity, profit-maximising discrimination equilibria exist. There, a group of majority workers is paid higher wages than a group of minority workers, who may even be completely excluded. Minimum wages can reduce such discrimination and increase employment. We discuss how these results relate to empirical evidence on downward wage rigidity, immigration, the gender pay gap and credentialism.
Variation and Variability in Skeletal Ossification of the Gray Short-tailed Opossum, Monodelphis domestica
Authors: Morris Z S , Colbert M W , Rowe T B
Published: July 2024

Synopsis

By reconstructing and comparing the sequence of ontogenetic (embryonic development and post-natal growth) events across species, developmental biologists have gained unique insights into the key processes underlying the evolution of modern lineages and their extinct relatives. However, despite the importance of intraspecific variation to evolutionary transformation and lineage divergence, variation in the sequence of developmental events is seldom acknowledged. Thus, how much variation or variability should be expected during ontogeny remains poorly understood and it is an open question to what extent it impacts interspecific comparisons of developmental patterns. To address this crucial question, we studied the skeletal development of the important biomedical and developmental model organism, Monodelphis domestica. We investigated cranial, forelimb, and hindlimb elements using ontogenetic sequence analysis (OSA) to quantify and assess the full range of variation and variability in the sequence of ossification. Our study documented that previously unrecognized variation exists during M. domestica ontogeny—with over 5000 sequences for the full 92 event analysis. Further, OSA revealed unexpectedly high variability (i.e., the propensity to express variation) in the sequence of ossification for the skull and across the entire skeleton. Reconstructed modal sequences were generally in agreement with previously recognized patterns, including earlier ossification of the facial skeleton and a slight offset between forelimb and hindlimb development. However, the full range of variation shows that the majority of specimens in our analysis followed developmental trajectories distinct from those recovered by prior studies. This level of variation is quite remarkable and demonstrates the importance of assessing intraspecific ontogenetic variation. By quantifying sequence polymorphism and studying how developmental variation and variability differ among species, we can clarify more precisely how developmental patterns differ among species and gain insights into how ontogeny itself evolves.
The evolution of EU competition law and policy in the pharmaceutical sector: long-lasting impacts of a pandemic
Authors: Hosseini Mina
Published: July 2024

This article investigates the evolution of the European Union (EU) competition law and policy enforcement in the pharmaceuticals sector, focusing on the impact of the coronavirus disease 2019 (COVID-19) crisis as a turning point. Before COVID-19, EU competition authorities’ goals and priorities focused on pay-for-delay agreements between originators and generic pharmaceutical undertakings. During COVID-19, the European Commission developed soft laws (such as temporary frameworks and comfort letters) enabling undertakings to cooperate to increase access to essential health products and COVID-19 vaccines. In the post-pandemic era, initiatives like the Pharmaceutical Strategy for Europe, the Single Market Emergency Instrument (SMEI), the Health Emergency Response Authority (HERA), the compulsory licensing proposal and the upcoming changes in the pharmaceutical regulations reflect a patient-centred approach and diverse agenda. This article underscores the move towards a more inclusive EU competition law and policy framework in the pharmaceutical sector as part of this evolution.
Bacterial exopolysaccharide amendment improves the shelf life and functional efficacy of bioinoculant under salinity stress
Authors: Srivastava Sonal , Bhattacharjee Annapurna , Dubey Shubham , Sharma Shilpi
Published: July 2024

Aim

Bacterial exopolysaccharides (EPS) possess numerous properties beneficial for the growth of microbes and plants under hostile conditions. The study aimed to develop a bioformulation with bacterial EPS to enhance the bioinoculant’s shelf life and functional efficacy under salinity stress.

Methods and results

High EPS-producing and salt-tolerant bacterial strain (Bacillus haynessi SD2) exhibiting auxin-production, phosphate-solubilization, and biofilm-forming ability, was selected. EPS-based bioformulation of SD2 improved the growth of three legumes under salt stress, from which pigeonpea was selected for further experiments. SD2 improved the growth and lowered the accumulation of stress markers in plants under salt stress. Bioformulations with varying EPS concentrations (1% and 2%) were stored for 6 months at 4°C, 30°C, and 37°C to assess their shelf life and functional efficacy. The shelf life and efficacy of EPS-based bioformulation were sustained even after 6 months of storage at high temperature, enhancing pigeonpea growth under stress in both control and natural conditions. However, the efficacy of non EPS-based bioformulation declined following four months of storage. The bioformulation (with 1% EPS) modulated bacterial abundance in the plant’s rhizosphere under stress conditions.

Conclusion

The study brings forth a new strategy for developing next-generation bioformulations with higher shelf life and efficacy for salinity stress management in pigeonpea.
KG-LIME: predicting individualized risk of adverse drug events for multiple sclerosis disease-modifying therapy
Authors: Patterson Jason , Tatonetti Nicholas
Published: July 2024

Objective

The aim of this project was to create time-aware, individual-level risk score models for adverse drug events related to multiple sclerosis disease-modifying therapy and to provide interpretable explanations for model prediction behavior.

Materials and Methods

We used temporal sequences of observational medical outcomes partnership common data model (OMOP CDM) concepts derived from an electronic health record as model features. Each concept was assigned an embedding representation that was learned from a graph convolution network trained on a knowledge graph (KG) of OMOP concept relationships. Concept embeddings were fed into long short-term memory networks for 1-year adverse event prediction following drug exposure. Finally, we implemented a novel extension of the local interpretable model agnostic explanation (LIME) method, knowledge graph LIME (KG-LIME) to leverage the KG and explain individual predictions of each model.

Results

For a set of 4859 patients, we found that our model was effective at predicting 32 out of 56 adverse event types (P < .05) when compared to demographics and past diagnosis as variables. We also assessed discrimination in the form of area under the curve (AUC = 0.77 ± 0.15) and area under the precision-recall curve (AUC-PR = 0.31 ± 0.27) and assessed calibration in the form of Brier score (BS = 0.04 ± 0.04). Additionally, KG-LIME generated interpretable literature-validated lists of relevant medical concepts used for prediction.

Discussion and Conclusion

Many of our risk models demonstrated high calibration and discrimination for adverse event prediction. Furthermore, our novel KG-LIME method was able to utilize the knowledge graph to highlight concepts that were important to prediction. Future work will be required to further explore the temporal window of adverse event occurrence beyond the generic 1-year window used here, particularly for short-term inpatient adverse events and long-term severe adverse events.
Wide-binary eccentricity distribution in young star clusters: dependence on the binary separation and mass
Authors: Mathew Sajay Sunny , Xu Siyao , Federrath Christoph , Hu Yue , Seta Amit
Published: July 2024

We study the wide-binary eccentricity (e) distribution in young star clusters and the role of turbulence in setting the form of the e distribution using magnetohydrodynamical simulations of star cluster formation. The simulations incorporate gravity, turbulence, magnetic fields, protostellar heating, and jets/outflows. We find that (1) simulations that employ purely compressive turbulence driving produce binaries with a superthermal e distribution [$\alpha \gt 1$ in $p(e) \propto e^\alpha$], while simulations with purely solenoidal driving or natural mixture of driving modes produce subthermal/thermal distributions ($\alpha \le$ 1), (2) the e distribution over the full range of binary separations in our simulations is set at the early stages of the star cluster formation process, (3) while binaries (separation of $r_{\mathrm{pair}} \le 1000\, \mathrm{AU}$) have subthermal to thermal e distributions ($\alpha \sim 0.8$), wide binaries ($r_{\mathrm{pair}} \gt 1000\, \mathrm{AU}$) have a superthermal distribution ($\alpha \sim 1.8$), and (4) low-mass binary systems (system masses of $M_{\mathrm{sys}} \le 0.8\, \mathrm{M_\odot }$) have a highly superthermal distribution ($\alpha \sim 2.4$), whereas high-mass systems ($M_{\mathrm{sys}} \gt 0.8\, \mathrm{M_\odot }$) exhibit a subthermal/thermal distribution ($\alpha \sim 0.8$). The binary eccentricity distribution is often modelled as a thermal distribution. However, our results suggest that the e distribution depends on the range of separation of the sampled binaries, which agrees with the findings from recent Gaia observations. We conclude that the dependence of the e distribution on the binary separation and mass is linked to the binary formation mechanism governed by the turbulent properties of the parent cloud.
The preface: Toward higher-Tc superconductivity under lower pressure—from binary to ternary superhydrides
Authors: Zhang Fu-Chun , Mao Ho-Kwang , Xie Xin-Cheng
Published: July 2024

This is the Preface to Special Topic: Challenges to Achieving Room-Temperature Superconductivity in Superhydrides under Pressure.
Forum Marketing in International Commercial Courts?
Authors: Antonopoulou Georgia
Published: July 2024

Forum selling is a legal term used to describe the practices of courts and judges, geared towards attracting cases, such as increasing the predictability of judgments or speeding up trials. However, do courts also go beyond forum selling to attract cases? Taking international commercial courts as its focus, this article explores how these courts market themselves to attract cases and coins the term ‘forum marketing’. It demonstrates that the courts’ recent establishment, coupled with their voluntary jurisdiction, creates a compelling context, which encourages them to engage in forum marketing. The article argues that forum marketing is not merely a byproduct of the competition in commercial dispute resolution, but a powerful mechanism with deeply persuasive, normative and, effectively, structuring properties. Forum marketing is central to disseminating and reinforcing a pro-business approach in civil justice, consequently setting the stage for procedural inequality and a one per cent procedure.
Moral psychology as soul-picture
Authors: Russell Francey
Published: July 2024

Iris Murdoch offers a distinctive conception of moral psychology. She suggests that to develop a moral psychology is to develop what she calls a soul-picture; different philosophical moral psychologies are, as she puts it, ‘rival soul-pictures’. In this paper, I clarify Murdoch's generic notion of ‘soul-picture’, the genus of which, for example, Aristotle's, Kant's, Nietzsche's, and Murdoch's constitute rival species. Are all philosophical moral psychologies soul-pictures? If not, what are the criteria that a moral psychology must meet in order to qualify as a soul-picture? I propose five key dimensions. A soul-picture provides a picture of the soul or self, that is (1) holistic, (2) value-rich and psychologically realistic (for Murdoch these are intertwined), (3) reflexive, (4) therapeutic, and (5) the articulation of which makes use of imaginative language.
Advances in biomaterials for oral-maxillofacial bone regeneration: spotlight on periodontal and alveolar bone strategies
Authors: Li Nayun , Wang Jinyu , Feng Guangxia , Liu Yuqing , Shi Yunsong , Wang Yifan , Chen Lili
Published: July 2024

The intricate nature of oral-maxillofacial structure and function, coupled with the dynamic oral bacterial environment, presents formidable obstacles in addressing the repair and regeneration of oral-maxillofacial bone defects. Numerous characteristics should be noticed in oral-maxillofacial bone repair, such as irregular morphology of bone defects, homeostasis between hosts and microorganisms in the oral cavity and complex periodontal structures that facilitate epithelial ingrowth. Therefore, oral-maxillofacial bone repair necessitates restoration materials that adhere to stringent and specific demands. This review starts with exploring these particular requirements by introducing the particular characteristics of oral-maxillofacial bones and then summarizes the classifications of current bone repair materials in respect of composition and structure. Additionally, we discuss the modifications in current bone repair materials including improving mechanical properties, optimizing surface topography and pore structure and adding bioactive components such as elements, compounds, cells and their derivatives. Ultimately, we organize a range of potential optimization strategies and future perspectives for enhancing oral-maxillofacial bone repair materials, including physical environment manipulation, oral microbial homeostasis modulation, osteo-immune regulation, smart stimuli-responsive strategies and multifaceted approach for poly-pathic treatment, in the hope of providing some insights for researchers in this field. In summary, this review analyzes the complex demands of oral-maxillofacial bone repair, especially for periodontal and alveolar bone, concludes multifaceted strategies for corresponding biomaterials and aims to inspire future research in the pursuit of more effective treatment outcomes.
‘Help Shelter Mend a Broken Family’: Homes, Homelessness, and Crisis in 1960s Britain
Authors: Page Adam
Published: July 2024

In 1966, a new homelessness charity, Shelter, set out to redefine the homeless as impoverished families enduring poor or insecure housing rather than single men living on the street. Through a series of ‘hard-hitting’ reports and adverts, the group highlighted the destructiveness of poor housing on young families and gained a prominent national voice. This article examines Shelter’s campaigns in the 1960s to examine how debates about homes and homelessness can reframe the development of discourses of ‘crisis’ that defined the 1970s and provided a key narrative of Thatcherism. It focuses on how Shelter deployed ideas of childhood, family, and the family home, often echoing theories of leading child psychiatrists of the post-war period, to warn of the profound and acute danger that the housing crisis represented to British society. Shelter’s prominent and successful adverts and campaigns drew on growing anxieties about social and economic crisis, but did not discuss key issues of unemployment, racial discrimination, and deindustrialization. Instead, Shelter’s campaigns focused on the damage poor housing did to family life and the education and life chances of individual children. Discourses of crisis in this period are often associated with ‘inner cities’ and failing reconstruction schemes, but Shelter presented an image of social crisis that was centred in the family and the family home. By analysing how Shelter drew on fears about the coming social crisis, the article suggests that the family home and the life chances of individuals were central to popular understandings and perceptions of crisis before the 1970s.
Behavioral, biochemical, histopathological evaluation and gene expression of brain injury induced by nanoceria injected intranasal or intraperitoneal in mice
Authors: Saeed Hanan E , Ibrahim Rasha Ragab , Kamel Shaimaa , El-Nahass El-Shaymaa , Khalifa Ahlam G
Published: July 2024

Background

Nanotechnology has shown a remarkable progress nevertheless, there is a growing concern about probable neurotoxic and neurodegenerative effects due to NPs exposure. Various toxicological and epidemiological studies reported that the brain is a main target for ultrafine particles. Brain inflammation is considered as a possible mechanism that can participate to neurotoxic and neurodegenerative effects. Whether nanoparticles (NPs) may produce neurotoxicity and promote neurodegenerative is largely unstudied. The present study was done to investigate whether intranasal and intra-peritoneal exposure to cerium oxide nanoparticles (CeO2NPs, nanoceria (NC)) could cause neurotoxicity and neurodegenerative changes in the brain tissue through conducting some behavioral tests, biochemical evaluation, histopathological examinations of brain hippocampus and gene expressions.

Method

Fifteen mice were separated into 3 equal groups. In group (I) “control group”, mice were received distilled water orally and kept as a control group. Mice in the group (II) “NC I/P group” were injected i.p with cerium oxide nanoparticles at a dose of 40 mg/kg b.wt, twice weekly for 3 weeks. In group (III) “NC I/N group” mice were received nanoceria intranasally (40 mg/kg b.wt), twice weekly for 3 weeks.

Results

Exposure to nanceria resulted in oxidative damage in brain tissue, a significant increase in malondialdehyde (MDA) and acetylcholinestrase (AchE) levels, significant decrease in reduced glutathione (GSH) concentration, upregulation in the apoptosis-related genes (c-Jun: c-Jun N-terminal kinases (JNKs), c-Fos: Fos protooncogene, AP-1 transcription factor subunit, c-Myc: c-myelocytomatosis oncogene product or MYC protooncogene, bHLH transcription factor), locomotor and cognitive impairment in mice but the effect was more obvious when nanoceria adminstred intraperitoneally.

Conculsion

Nanoceria cause oxidative damage in brain tissue of mice when adminstred nanoceria intraperitoneally more than those received nanoceria intranasal.
Integrative taxonomy clarifies the armoured catfish Hypostomus pusarum (Starks) species complex (Siluriformes: Loricariidae) and reveals a new species in the drainages of Northeastern Brazil
Authors: Lustosa-Costa Silvia Yasmin , Ramos Telton Pedro Anselmo , Zawadzki Cláudio Henrique , Jacobina Uedson Pereira , Lima Sergio Maia Queiroz
Published: July 2024

Hypostomus is the most species-rich genus within the family Loricariidae and is widely distributed throughout the Neotropical region. Nonetheless, the diversity and distribution of these species have still large knowledge gaps. This scenario is more significant in some regions, such as the northeast of Brazil. In this region, the first species of the genus, H. pusarum, was described in the Northeast Caatinga and Costal Drainages ecoregion. Six congeners were subsequently described in the same ecoregion, all sharing the same colour pattern making them difficult to distinguish. All of them are collectively referred to as the H. pusarum complex. The present work seeks to clarify the diversity that constitutes the H. pusarum complex through an integrative study using molecular and morphological data. The results indicate that H. carvalhoi, H. jaguribensis, H. nudiventris, H. papariae, and H. salgadae are all junior synonyms of H. pusarum. However, one of the morphotypes that occurs in the Parnaíba River is a new species that differs from the others by the absence of a developed medial buccal papilla and the presence of a pre-anal plate. The data provided here highlight the importance of integrative taxonomy for assessing diversity in complex and diverse groups in the Neotropics.
Outcomes of De Novo Oligometastatic Breast Cancer Treated With Surgery of Primary and Metastasis Directed Radiotherapy
Authors: Pujari Lincoln , Suresh Arvind , Chowdhury Zachariah , Pradhan Satyajit , Tripathi Mayank , Gupta Anuj , Singh Prarabdh , Giridhar Prashanth , Kapoor Ankita R. , Shinghal Abhishek , Sansar Bipinesh , MV Manikandan
Published: July 2024

Objectives:

With sensitive imaging for breast cancer, the question arises whether present-day oncologists treat dOMBC with palliative systemic therapy (ST), which, a few years earlier, would have been treated with curative intent. We retrospectively analyzed outcomes of dOMBC treated with curative intent using a combination of surgery, metastasis-directed radiotherapy (RT), and adjuvant/neoadjuvant ST and have also explored the possible role of total lesional glycolysis of metastases and p53 immunohistochemistry in predicting outcomes.

Methods:

Data were collected from a prospectively maintained database using electronic medical records and Radiation Oncology Information System. In the study, dOMBC was defined as up to 3 metastatic sites, all amenable to treatment with ablative RT and primary and axillary disease amenable to curative surgery. Patients were treated with surgery, ST, and RT.

Results:

Patients underwent either breast conservation surgery or modified radical mastectomy. Patients were treated with 6 to 8 cycles of chemotherapy in the neoadjuvant and/or adjuvant setting. Hormone receptor-positive patients received either tamoxifen or aromatase inhibitors. Trastuzumab was offered to Her-2-neu receptor-positive patients. RT included locoregional RT and metastases-directed ablative body RT. The median progression-free survival was 39 months (95% CI: −28.7 to 50.1 mo). Two and 3 year estimated disease-free survival (DFS) was 79% and 60.5%, respectively. The median overall survival was not reached. The estimated 3-year overall survival was 87.3%. Total lesional glycolysis of metastases score and p53 status did not affect DFS.

Conclusion:

Combination treatment of surgery, metastases-directed ablative RT, and ST may provide prolonged DFS in dOMBC.
Palliative care in advanced pulmonary fibrosis
Authors: Kalluri Meena
Published: July 2024

Purpose of review

Updated clinical practice guidelines for pulmonary fibrosis recommend early integrated palliative care using a primary palliative approach. Clinicians need to be aware of the various palliative interventions in order to implement guidelines’ recommendations. This review provides an update on evidence-based palliative therapies.

Recent findings

Literature review indicates early integration of palliative care in pulmonary fibrosis is feasible and meets patient needs. Key components of a primary palliative approach include comprehensive symptoms and needs screening, systematic symptom management using nonpharmacologic interventions, supplemental oxygen and opioids for dyspnea and cough. Patient-centered communication is essential for successful integration of palliative care. Early, iterative advance care planning in clinic to understand patient goals, values and preferences for current and future care, improves patient care and satisfaction. Prioritizing caregiver inclusion in clinics can address their needs. Collaborating with a multidisciplinary allied team facilitates integration of palliative care and supports patients throughout the disease course. Different models of palliative care delivery exist and can be adapted for local use. The use of artificial intelligence algorithms and tools may improve care and continuity.

Clinicians must develop competency in palliative care. Organizational and policy support is essential to enable seamless integration of palliative care throughout the care continuum.
The future of clinical trials in idiopathic pulmonary fibrosis
Authors: Spagnolo Paolo , Maher Toby M.
Published: July 2024

Purpose of review

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a poor prognosis and limited therapeutic options. A multitude of promising compounds are currently being investigated; however, the design and conductance of late-phase clinical trials in IPF has proven particularly challenging.

Recent findings

Despite promising phase 2 data, ziritaxestat, an autotaxin inhibitor, pentraxin-2, an endogenous protein that regulates wound healing and fibrosis, and pamrevlumab, a human monoclonal antibody against connective tissue growth factor, failed to show efficacy in phase 3 trials. Endpoint selection is critical for the design, execution, and success of clinical trials; recently, attention has been paid to the assessment of how patients feel, function, and survive with the aim of aligning scientific objectives and patient needs in IPF. External control arms are control patients that derive from historical randomized controlled trials, registries, or electronic health records. They are increasingly used to assess treatment efficacy in clinical trials owing to their potential to reduce study duration and cost and increase generalizability of findings.

Advances in study design, end point selection and statistical analysis, and innovative strategies for more efficient enrolment of study participants have the potential to increase the likelihood of success of late-phase clinical trials in IPF.
Prevalence and clinical characterization of hepatitis D virus (HDV) infection among Sudanese patients with hepatitis B virus (HBV): a cross-sectional study
Authors: Alajab Mohamed Bushra , Ibn Auf Bushra , Rafei Ahmed , Abdo Abdelmoneim Eltayeib
Published: July 2024

Background:

Sudan has a high prevalence of hepatitis B surface antigen, exceeding 8%. The prevalence of hepatitis B varies across different regions of Sudan, ranging from 6.8% in central Sudan to as high as 26% in southern Sudan. Hepatitis D virus (HDV) relies on HBV for replication and can accelerate the progression of HBV-related liver diseases, leading to more severe outcomes. This study aims to determine the prevalence of HDV infection among Sudanese patients with HBV-related liver diseases and to investigate the clinical characteristics of patients with HDV co-infection.

Design/method:

This descriptive cross-sectional hospital-based study was conducted in Sudan between June and September 2022. Ninety HBV patients aged 16 years and above were included. Patients were interviewed using a structured questionnaire, and medical histories and examinations were recorded. Investigations included liver function tests, abdominal ultrasounds, and ELISA for Anti-HDV IgG.

Results:

In this study of 90 HBV patients, most were male (68.9%) and under 40 years old (58.9%). HDV-IgG antibodies were found in 8 patients (8.9%), all male. Among the HDV-positive patients, one (12.5%) had jaundice and one (12.5%) had ascites. Elevated ALT levels were seen in 50% of HDV-positive patients. One (12.5%) HDV-positive patient had low albumin. Cirrhosis was present in 25% of HDV-positive patients, and HCC was present in 12.5% of HDV-positive patient.

Conclusion:

The prevalence of HDV infection among Sudanese patients with HBV-related liver diseases is 8.9%. This highlights the need for enhanced screening and diagnostic measures in Sudanese populations. Further research is needed to develop targeted interventions.
The beneficial influences of vitamin D intake on inflammation and oxidative stress in infertile women with polycystic ovary syndrome
Authors: Asemi Reza , Ahmadi Asouri Sahar , Aghadavod Esmat , Jamilian Mehri
Published: July 2024

Objective:

Oxidative stress and inflammation play a vital function in the pathophysiology of polycystic ovary syndrome (PCOS) and infertility. The aim of this work was to control the impacts of vitamin D intake on metabolic profiles in infertile subjects with PCOS.

Trial design and methods:

This randomized, double-blinded, placebo-controlled clinical trial was carried out among 40 infertile women with PCOS. Subjects were randomly divided into two intervention groups to take either 50 000 IU vitamin D (n=20) or placebo (n=20) weekly for 8 weeks. Metabolic profiles and few inflammatory cytokines expression evaluated on peripheral blood mononuclear cells (PBMCs) of participants, using real-time polymerase chain reaction (RT-PCR) method.

Results:

Vitamin D intake decreased high-sensitivity C-reactive protein (hs-CRP) (−0.9±1.1 vs. 0.3±0.9 mg/l, P=0.002) and elevated total antioxidant capacity (TAC) levels (49.2±60.2 vs. −50.6±161.8 mmol/l, P=0.02) compared with placebo; but no significant effects on other metabolic parameters were observed. Moreover, a significant downregulation of tumor necrosis factor alpha (TNF-α) expression (P=0.03) was observed after taking vitamin D compared with the placebo.

Conclusions:

Overall, vitamin D intake for eight weeks had beneficial impacts on hs-CRP, TAC, and TNF-α among infertile women with PCOS.
Improving the Recruitment and Retention of Unlicensed Assistive Personnel
Authors: Coroneos-Shannon Danene L. , Lancaster Rachelle
Published: July 2024

With increasing demands for unlicensed assistive personnel, strategies for optimizing recruitment and retention are paramount. The purpose of this quality improvement project was to increase the recruitment and retention of unlicensed assistive personnel in a nonprofit healthcare organization. Initiatives included expanding academic affiliations enhancing pipeline, developing a tailored onboarding program, and introducing a clinical ladder. Results indicate increases in numbers of academic affiliations and hiring, with unlicensed assistive personnel turnover rates below national averages.
Strategic Steps to Gaining Approval for Increased Nurse Residency Program Coordinator Full-Time Equivalent Resources
Authors: Cantrell Faith , DelMonte JoAnn , Butler Jana , Smith Katherine , Garcher Dana
Published: July 2024

There is increased reliance on newly licensed nurses to fill open healthcare positions. Nurse residency programs (NRPs) provide the training, mentorship, and support newly licensed nurses require to successfully transition to professional practice. Research suggests that NRPs improve nurse retention, clinical outcomes, and organizational outcomes. Sufficient NRP full-time equivalents are needed to ensure adequate support and program management. This article describes how a Colorado hospital system secured additional NRP Coordinator full-time equivalent using a six-step process.
Chagas disease in the immunocompromised host
Authors: Clark Eva H. , Bern Caryn
Published: July 2024

Purpose of review

To highlight recent advances in our understanding of Trypanosoma cruzi infection in immunocompromised individuals, a condition that is increasingly recognized as populations shift and use of immunosuppressive medications becomes more commonplace.

Recent findings

Chagas disease screening programs should include people at risk for both Chagas disease and immunocompromise, e.g. people who have resided for ≥6 months in endemic Latin America who have an immunocompromising condition such as HIV or who are planned to start an immunosuppressive medication regimen. The goal of identifying such individuals is to allow management strategies that will reduce their risk of T. cruzi reactivation disease. For people with HIV-T. cruzi coinfection, strict adherence to antiretroviral therapy is important and antitrypanosomal treatment is urgent in the setting of symptomatic reactivation. People at risk for T. cruzi reactivation due to immunosuppression caused by advanced hematologic conditions or postsolid organ transplantation should be monitored via T. cruzi qPCR and treated with preemptive antitrypanosomal therapy if rising parasite load on serial specimens indicates reactivation. Reduction of the immunosuppressive regimen, if possible, is important.

Chronic Chagas disease can lead to severe disease in immunocompromised individuals, particularly those with advanced HIV (CD4+ < 200 cells/mm3) or peri-transplantation.
Spartinivicinus poritis sp. nov., a red pigment-producing bacterium isolated from a scleractinian coral Porites lutea
Authors: Sajid Sumbal , Zhang Guoqiang , Zhang Zongyao , Lu Yishan , Chen Lianguo , Cai Lin
Published: July 2024

A Gram-stain-negative, red pigment-producing, aerobic, and rod-shaped bacterial strain (A2-2T) was isolated from a bleached scleractinian coral (Porites lutea). Strain A2-2T grew with 1.0–7.0 % (w/v) NaCl (optimum, 3.0 %), at pH 6.0–11.0 (optimum, pH 8.0), and at 18–41 °C (optimum, 35 °C). Results of phylogenetic analysis based on 16S rRNA gene sequences suggested that strain A2-2T fell within the genus Spartinivicinus and was closely related to Spartinivicinus ruber S2-4-1HT (98.1 % sequence similarity) and Spartinivicinus marinus SM1973T (98.0 % sequence similarity). The predominant cellular fatty acids of strain A2-2T were C16 : 0 (31.0 %), summed feature 3 (29.0 %), summed feature 8 (11.7 %), C12 : 0 3-OH (6.4 %), and C10 : 0 3-OH (5.5 %), while the major respiratory quinone was Q-9. The polar lipids mainly comprised phosphatidylethanolamine, phosphatidylglycerol, diphosphatidylglycerol, and an unidentified phospholipid. The genome size of strain A2-2T was 6.8 Mb, with a G+C content of 40.2 mol%. The DNA–DNA hybridization value was 24.2 % between A2-2T and S. ruber S2-4-1HT and 36.9 % between A2-2T and S. marinus SM1973T, while the average nucleotide identity values were 80.1 and 88.8 %, respectively. Based on these findings, strain A2-2T could be recognized to represent a novel species of the genus Spartinivicinus, for which the name Spartinivicinus poritis sp. nov. is proposed. The type strain is A2-2T (=MCCC 1K08228T=KCTC 8323T).