bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Peripheral and Central Insulin Resistance in Neuropsychiatric Disorders
Authors: Alagiakrishnan Kannayiram , Halverson Tyler
Published: November 2024

Insulin acts on different organs, including the brain, which helps it regulate energy metabolism. Insulin signaling plays an important role in the function of different cell types. In this review, we have summarized the key roles of insulin and insulin receptors in healthy brains and in different brain disorders. Insulin signaling, as well as insulin resistance (IR), is a major contributor in the regulation of mood, behavior, and cognition. Recent evidence showed that both peripheral and central insulin resistance play a role in the pathophysiology, clinical presentation, and management of neuropsychiatric disorders like Cognitive Impairment/Dementia, Depression, and Schizophrenia. Many human studies point out Insulin Resistance/Metabolic Syndrome can increase the risk of dementia especially Alzheimer’s dementia (AD). IR has been shown to play a role in AD development but also in its progression. This review article discusses the pathophysiological pathways and mechanisms of insulin resistance in major neuropsychiatric disorders. The extent of insulin resistance can be quantified using IR biomarkers like insulin levels, HOMA-IR index, and Triglyceride glucose–body mass index (TyG–BMI) levels. IR has been shown to precede neurodegeneration. Human trials showed current treatment with certain antidiabetic drugs, as well as life style management, like weight loss and exercise for IR, have shown promise in the management of cognitive/neuropsychiatric disorders. This may pave the pathway to the development of new therapeutic approaches to these challenging disorders of dementia and psychiatric diseases. Recent clinical trials are showing some encouraging evidence for these pharmacological and nonpharmacological approaches for IR in psychiatric and cognitive disorders, even though more research is needed to apply this evidence into clinical practice. Early identification and management of IR may help as a strategy to potentially alter neuropsychiatric disorders onset as well as its progression
Intra-Articular Physiological Saline in Temporomandibular Disorders May Be a Treatment, Not a Placebo: A Hypothesis, Systematic Review, and Meta-Analysis
Authors: Chęciński Maciej , Chęcińska Kamila , Cholewa-Kowalska Katarzyna , Romańczyk Kalina , Chlubek Dariusz , Sikora Maciej
Published: November 2024

Background: Intra-articular injections reduce pain in patients with temporomandibular joint (TMJ) disorders who are unresponsive to conservative treatment. Hyaluronic acid, blood products, and medications provide rapid relief when administered this way, although their mechanisms of action remain unclear. In control groups, which are intended to be untreated, 0.9% NaCl is typically delivered. The hypothesis that “normal saline injections in TMJ cavities produce a therapeutic effect” is proposed, with an exploration of its potential verification, alongside a systematic review and meta-analysis of studies on intra-TMJ 0.9% NaCl. Methods: Randomized controlled trials (RCTs) on patients with TMJ internal derangement, arthritis, or degeneration were selected under PRISMA 2020 and assessed with RoB2. Results: Seven RCTs with 359 patients were included. Weekly follow-ups revealed a decrease in articular pain by 23.72% (SE: 0.84%; 95% CI: 24.38–21.06%; p < 0.01), and monthly follow-ups indicated a decrease of 34.01% (SE: 1.09%; 95% CI: 36.16–31.86%; p < 0.01) compared to the baseline values. These findings were grounded in low-risk-of-bias evidence on 267 patients in five RCTs and 222 patients in four RCTs, respectively. Conclusions: The hypothesis warrants further testing to determine whether, in addition to the known biological activity of typical injectables, the mechanical action also contributes to pain relief.
Cirrhosis Progression Is Not Associated with Clinically Significant Alterations in Global Hemostasis Assessed by Thromboelastography
Authors: Crăciun Rareș , Buliarcă Alina , Matei Daniela , Grapă Cristiana , Nenu Iuliana , Ștefănescu Horia , Mocan Tudor , Procopeț Bogdan , Spârchez Zeno
Published: November 2024

(1) Background: Cirrhosis is associated with frequent alterations in standard coagulation tests that do not adequately reflect hemostasis. Thromboelastography provides a global assessment of coagulation and evaluates the functional status of clotting factors, fibrinogen, platelets, and fibrinolysis. The study aimed to assess whether liver disease severity leads to progressive alterations in the thromboelastography-based assessment of coagulation. (2) Methods: Consecutive patients with cirrhosis and abnormal standard coagulation tests (at least one of International Normalized Ratio > 2, platelet count < 50 × 103/µL, fibrinogen < 200 mg/dL) were analyzed using native thromboelastography. (3) Results: A total of 106 patients were included, of whom 69 (65.1%) had a normal thromboelastography. While the standard coagulation tests were significantly worse in patients in the Child C group (n = 62, 58.5%) than in patients staged in Child A and B, no significant differences existed between any of the thromboelastography variables. Of the 50 patients (47.1%) with an International Normalized Ratio > 2, only two patients (4%) had features of hypocoagulation, while 26% had features of hypercoagulability on thromboelastography. Patients with a platelet count < 50 × 103/µL had significantly lower platelet function as assessed by thromboelastography, yet only eight patients (20%) met the criteria for platelet transfusion. A thromboelastography-based transfusion protocol might lead to a 94.6% reduction in blood product transfusion indications in a simulation where the included patients would require interventional procedures. (4) Conclusion: Standard coagulation tests showed a poor correlation with thromboelastography. Based on thromboelastography, patients with severe, decompensated liver disease have a preserved hemostasis balance despite abnormal standard coagulation tests. Therefore, standard coagulation tests should not be used to guide the administration of blood products in patients with cirrhosis.
The Time Course of Catecholamine Dose Reduction in Septic Shock as a Predictor of Bacterial Susceptibility to Empiric Antimicrobial Therapy: A Retrospective Observational Study
Authors: Kuwana Tsukasa , Kinoshita Kosaku , Yamaya Yurina , Takahashi Ken , Yamaguchi Junko , Sakurai Atsushi , Imai Toru
Published: November 2024

Background/Objectives: The 28-day mortality rate for septic shock is high, necessitating rapid and effective empiric antimicrobial therapy. In this study, we investigate whether the rate of catecholamine dose reduction in septic shock can indicate bacterial susceptibility to initial antimicrobial therapy or not. Methods: This retrospective observational study involved 108 adult patients with bacteraemia and septic shock admitted to the intensive care unit of Nihon University Itabashi Hospital between January 2017 and December 2023. They were classified into the Susceptible or Resistant groups based on the bacteria’s susceptibility to the initial empiric antimicrobial therapy. Catecholamine dosages were converted to norepinephrine equivalent (NEE) scores, with the time course from the peak to the end of administration measured at NEE reductions. Results: Of the 108 patients, 94 were in the Susceptible group and 14 in the Resistant group. The Susceptible group showed faster reductions in catecholamine doses: the time to reduce the dose from the maximum NEE to 25% was 19 vs. 49.5 h (p = 0.0057), and to 0%, it was 29 vs. 54 h (p = 0.0475). The time to reduce the dose from the maximum NEE to 75% was 8 vs. 12.5 h (p = 0.0733), and to 50% it was 13 vs. 21.5 h (p = 0.1081). Conclusions: In septic shock with bacteraemia, a faster catecholamine dose reduction indicates bacterial susceptibility to the initial empiric antibiotics. This reduction rate can serve as an early clinical indicator of the appropriate initial empiric therapy.
Comparison of the Effectiveness of Body Surface Area Estimation Formulas in Predicting the Risk of Death in Patients with Heart Failure
Authors: Piecuch Małgorzata , Chylak Maciej , Górski Michał , Garbicz-Kata Jagoda , Szczyrba Anna , Buczkowska Marta , Malinowska-Borowska Jolanta , Nowak Jolanta Urszula , Niedziela Jacek T. , Gąsior Mariusz , Rozentryt Piotr
Published: November 2024

Background/Objectives: Body surface area is one of the most important anthropometric parameters in medicine. The study’s primary objective is to compare the consistency of the BSA estimation results through applying available formulas. Other objectives include determining the ability of these formulas to discriminate between death and survival in patients, comparing the formulas’ diagnostic features, and investigating whether the risk associated with a low BSA is independent of BMI. Methods: This study included 1029 patients (median age, 54 years; female, 13.7%; NYHA I/II/III/IV, 6.3%/36.5%/47.7%/9.5%) diagnosed with heart failure. For each patient, BSA was calculated using 25 formulas. Over the 3-year observation period, 31.2% of the patients died. Results: The average BSA value of the optimal discrimination thresholds was 1.79 m2 ± 0.084 m2 and the BSA difference between the estimators with the lowest (BSAMeeh1879) and the highest (BSANwoye1989) optimal discrimination thresholds was 0.42 m2. The lowest mortality rate was 35.2% and occurred in the subgroup of individuals with BSA values below the optimal discrimination threshold using the BSASchlich2010 estimator. The highest mortality was predicted when the estimator BSAMeeh1879 or BSALivingston&Lee2001 was used. Conclusions: Our study showed a relatively good concordance of 25 BSA estimators in BSA assessment in patients, without extremes of weight or height being known to disrupt it. All BSA estimators presented a significant, although weak, ability to discriminate death from survival at 3-year follow-up; however, BSA is not a very good predictor of HF mortality at 3 years. The higher risk of death in smaller patients, as shown by BSA, was independent of BMI in all but two BSA estimators.
Calcium Phosphate Loaded with Curcumin Prodrug and Selenium Is Bifunctional in Osteosarcoma Treatments
Authors: Wang Mingjie , Xu Chunfeng , Xu Dong , Du Chang , Liu Yuelian
Published: November 2024

Although SeO32− ions have been loaded onto calcium phosphate to treat a wide range of cancers, the quest to promote bone tissue regeneration is still ongoing. Curcumin (cur), an herbal extraction, can selectively inhibit tumor cells and promote osteogenesis. In this study, SeO32− ions were co-precipitated in biomimetic calcium phosphate (Se@BioCaP), and modified curcumin prodrug (mcur) was adsorbed on diverse Se@BioCaP surfaces (mcur-Se@BioCaP-Ads). Co-precipitation yielded Se@BioCaP with a significantly higher Se content and exhibited a tailorable micro-/nanostructure. The favorable pH-responsive release of Se and mcur from mcur-Se@BioCaP-Ads showed a synergistic anticancer efficiency in OS cells, enhancing OS cell inhibition more than a single dose of them, which might be associated with ROS production in OS cells. In addition, increased alkaline phosphatase activity and calcium nodule formation in MC3T3-E1 pre-osteoblasts were also verified. These results suggest this novel mcur-Se@BioCaP-Ads has promising and widespread potential in OS treatments.
Unilateral “Inactive” Condylar Hyperplasia: New Histological Data
Authors: Anastasi Michele Runci , Centofanti Antonio , Favaloro Angelo , Freni Josè , Nicita Fabiana , Vermiglio Giovanna , Anastasi Giuseppe Pio , Cascone Piero
Published: November 2024

Background: Unilateral condylar hyperplasia (UCH) is characterized by slow progression and enlargement of the condyle, accompanied by elongation of the mandibular body, resulting in facial asymmetry, occlusal disharmony, and joint dysfunction. This condition can be defined as “active” or “inactive”: the active form is characterized by continuous growth and dynamic histologic changes, whereas the inactive form indicates that the growth process has stabilized. Since there are few microscopic studies on the inactive form, this study aims to investigate the histological features and expression of key proteins and bone markers in patients diagnosed with inactive UCH. Methods: A total of 15 biopsies from patients aged 28 to 36 years were examined by light microscopy and immunofluorescence for collagen I and II, metalloproteinases 2 (MMP-2) and 9 (MMP-9), receptor activator of nuclear factor- kappa B (RANK), and osteocalcin. Results: Our findings indicate that during inactive UCH, the ongoing process is not entirely stopped, with moderate expression of collagen, metalloproteinases, RANK, and osteocalcin, although no cartilage islands are detectable. Conclusions: The present study shows that even if these features are moderate when compared to active UCH and without cartilage islands, inactive UCH could be characterized by borderline features that could represent an important trigger-point to possible reactivation, or they could represent a long slow progression that is not “self-limited”.
A Low-Power 5-Bit Two-Step Flash Analog-to-Digital Converter with Double-Tail Dynamic Comparator in 90 nm Digital CMOS
Authors: George Reena , Ch Nagesh
Published: November 2024

Low-power portable devices play a major role in IoT applications, where the analog-to-digital converters (ADCs) are very important components for the processing of analog signals. In this paper, a 5-bit two-step flash ADC with a low-power double-tail dynamic comparator (DTDC) using the control switching technique is presented. The most significant bit (MSB) in the proposed design is produced by only one low-power DTDC in the first stage, and the remaining bits are generated by the flash ADC in the second stage with the help of an auto-control circuit. A control circuit produced reference voltages with respect to the control input and mid-point voltage (Vk). The proposed design and simulations are carried out using 90 nm CMOS technology. The result shows that the peak differential non-linearity (DNL) and integral non-linearity (INL) are +0.60/−0.69 and +0.66/−0.40 LSB, respectively. The signal-to-noise and distortion ratio (SNDR) for an input signal having a frequency of 1.75 MHz is found to be 30.31 dB. The total power consumption of the proposed design is significantly reduced, which is 439.178 μW for a supply voltage of 1.2 V. The figure of merit (FOM) is about 0.054 pJ/conversion step at 250 MS/s. The present design provides low power consumption and occupies less area compared to the existing works.
Deep Learning-Based Automatic Estimation of Live Coral Cover from Underwater Video for Coral Reef Health Monitoring
Authors: Li Zechen , Zhao Shuqi , Lu Yuxian , Song Cheng , Huang Rongyong , Yu Kefu
Published: November 2024

Coral reefs are vital to marine biodiversity but are increasingly threatened by global climate change and human activities, leading to significant declines in live coral cover (LCC). Monitoring LCC is crucial for assessing the health of coral reef ecosystems and understanding their degradation and recovery. Traditional methods for estimating LCC, such as the manual interpretation of underwater survey videos, are labor-intensive and time-consuming, limiting their scalability for large-scale ecological monitoring. To overcome these challenges, this study introduces an innovative deep learning-based approach that utilizes semantic segmentation to automatically interpret LCC from underwater videos. That is, we enhanced PSPNet for live coral segmentation by incorporating channel and spatial attention mechanisms, along with pixel shuffle modules. Experimental results demonstrated that the proposed model achieved a mean Intersection over Union (mIoU) of 89.51% and a mean Pixel Accuracy (mPA) of 94.47%, showcasing superior accuracy in estimating LCC compared to traditional methods. Moreover, comparisons indicated that the proposed model aligns more closely with manual interpretations than other models, with an mean absolute error of 4.17%, compared to 5.89% for the original PSPNet, 6.03% for Deeplab v3+, 7.12% for U-Net, and 6.45% for HRNet, suggesting higher precision in LCC estimation. By automating the estimation of LCC, this deep learning-based approach can greatly enhance efficiency, thereby contributing significantly to global conservation efforts by enabling more scalable and efficient monitoring and management of coral reef ecosystems.
Amphotericin B Ocular Films for Fungal Keratitis and a Novel 3D-Printed Microfluidic Ocular Lens Infection Model
Authors: Rapti Chrysi , Luciano Francis C. , Anaya Brayan J. , Ramirez Bianca I. , Ongoren Baris , Dea-Ayuela María Auxiliadora , Lalatsa Aikaterini , Serrano Dolores R.
Published: November 2024

Fungal keratitis (FK), a severe eye infection that leads to vision impairment and blindness, poses a high risk to contact lens users, and Candida albicans remains the most common underpinning fungal pathogen in temperate climates. Patients are initially treated empirically (econazole 1% drops hourly for 24–48 h), and if there is no response, amphotericin B (AmB) 0.15% eye drops (extemporaneously manufactured to be stable for a week) are the gold-standard treatment. Here, we aim to develop a sustained-release AmB ocular film to treat FK with an enhanced corneal retention time. As there is a paucity of reliable in vitro models to evaluate ocular drug release and antifungal efficacy under flow, we developed a 3D-printed microfluidic device based on four chambers stacked in parallel, in which lenses previously inoculated with a C. albicans suspension were placed. Under the flow of a physiological fluid over 24 h, the release from the AmB-loaded film that was placed dry onto the surface of the wetted contact lenses was quantified, and their antifungal activity was assessed. AmB sodium deoxycholate micelle (dimeric form) was mixed with sodium alginate and hyaluronic acid (3:1 w/w) and cast into films (0.48 or 2.4%), which showed sustained release over 24 h and resulted in a 1.23-fold reduction and a 5.7-fold reduction in CFU/mL of C. albicans, respectively. This study demonstrates that the sustained delivery of dimeric AmB can be used for the treatment of FK and provides a facile in vitro microfluidic model for the development and testing of ophthalmic antimicrobial therapies.
Prevalence of Chronic Obstructive Pulmonary Disease in Patients with Nontuberculous Mycobacterial Pulmonary Disease: A Systemic Review and Meta-Analysis
Authors: Lee Hyun , Jang Jong Geol , Kim Youlim , Min Kyung Hoon , Ahn June Hong , Yoo Kwang Ha , Kang Min Gu , Kim Jong Seung , Moon Ji-Yong
Published: November 2024

Background/Objectives: Nontuberculous mycobacterial pulmonary disease (NTM-PD) is an important comorbidity of COPD. Although many studies have reported an association between COPD and NTM-PD, no clear estimate of the prevalence of COPD and its effects on survival times in patients with NTM-PD is available. This study aimed to investigate the prevalence of COPD and its impact on survival in patients with NTM-PD. Methods: All studies reporting the prevalence of COPD in patients with NTM between 1952 and 2021 were searched using PubMed in May 2023. The inclusion criteria were studies about patients with NTM and COPD. A random-effects meta-analysis was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: The pooled overall prevalence of COPD in patients with NTM-PD was 28% (95% confidence interval [CI], 22–35). Patients with NTM-PD were six times more likely to have COPD than those without NTM-PD (pooled odds ratio [OR], 6.26; 95% CI, 3.37–11.65). Male patients with NTM-PD had a four-fold higher risk of COPD than females (OR, 3.81; 95% CI, 1.18–12.35). The co-existence of COPD and NTM-PD was significantly associated with an increased risk of mortality compared with NTM-PD without COPD (OR, 3.65; 95% CI, 1.28–10.40). Conclusions: COPD is common in patients with NTM-PD, and patients with NTM-PD had a six-fold increase in the odds of having COPD than those without NTM-PD. The presence of COPD and NTM-PD had a significant negative effect on survival. These findings may support the need to assess the presence of COPD in patients with NTM-PD and the potential negative effects associated with the co-existence of COPD and NTM-PD.
Towards Healthy and Sustainable Human Settlement: Understanding How Local Communities Perceive and Engage with Spa Tourism Development Initiatives in Rural Areas
Authors: Mijatov Ladičorbić Maja , Dragin Aleksandra S. , Surla Tamara , Tešin Aleksandra , Amezcua-Ogáyar Juan Manuel , Calahorro-López Alberto , Stojanović Vladimir , Zadel Zrinka , Košić Kristina , Ivanović Olja Munitlak , Džigurski Anđelija Ivkov , Vujičić Miroslav D. , Knežević Milena Nedeljković , Bibić Ljubica Ivanović , Tomić Slavica , Anđelković Željko
Published: November 2024

This study investigated the intersection of healthy and sustainable human settlement, and land use for spa tourism in rural areas. Recognizing the crucial role of youth in shaping the future of tourism, this research aimed to provide an insight into the young local rural community representatives’ perception of sustainable spa tourism development and to identify whether these attitudes are shaped by their socio-demographic characteristics. The applied methodology was the Sustainable Tourism Attitude Scale (SUS-TAS). A total of 254 respondents took part in this research. Using SPSS 30.0.0, the gathered data were subjected to additional analyses based on factor analysis, descriptive statistics, and the general linear model. The results showed a general positive attitude of local community members towards the further development of spa tourism in their communities. The especially important factors were the following: long-term planning of development, environmental protection, negative attitudes towards spa tourism development, economic benefits, as well as community participation. By providing an empirical analysis based on the use of robust tools for measuring youth attitudes, this research offers valuable insights for policymakers, planners, and community leaders into how they can design and implement tourism strategies that align with sustainability principles while fostering local economic development and environmental stewardship. The ultimate goal is to contribute to the broader discussion on developing healthy, sustainable human settlements that balance economic benefits with ecological and social well-being. Synergy/harmony between communities and their natural surroundings is essential for the social, economic, and environmental sustainability of rural human settlements. Mineral springs and spas facilitate sensory experiences for individuals (both tourists and residents) through the utilization of natural resources and the environment.
Determinants of Public Participation in Watershed Management in Southeast China: An Application of the Institutional Analysis and Development Framework
Authors: Zeng Daile , Chen Boya , Wang Jingxin , Innes John L. , Lu Juliet , Guo Futao , Yan Yancun , Wang Guangyu
Published: November 2024

Increasingly, adaptive processes and decentralization are vital aspects of watershed governance. Equitable and sustainable water governance requires an understanding that different societal members have unique relationships with the environment and varying levels of interaction with policymakers. However, the factors facilitating public involvement under centralized governance remain less understood. This study combined the Institutional Analysis and Development framework with ordered probit regression to empirically investigate the determinants of willingness to participate (WTP) and actual participation of the public in integrated watershed management (IWM). Data from 933 valid questionnaires collected across 36 counties in Fujian, China, were used to define stakeholders’ perceptions of IWM. Results show that stakeholders are predominantly willing to participate in watershed conservation, management, or planning (85.9%), while only 32.8% frequently attend related events. Pro-environmental intentions were mainly shaped by interactional capacity—information exposure, interpersonal exchanges, and cross-reach support recognition—while actual participation was influenced by perceived biophysical conditions, rules-in-use, socioeconomic factors, and interactional capacity. Frequent observations of poor forest management practices were correlated with higher behavioral intentions, and socioeconomic dynamics significantly affected self-reported actual participation. Information sharing had the most substantial positive impact on both WTP and actual participation. These findings reinforce the necessity for an integrated and holistic approach to regional watershed resource management that fosters inclusivity and sustainability. This study provides workable insights into the social and institutional factors that shape public participation in watershed governance as it evolves toward decentralization.
A Novel Phenology-Based Index for Plastic-Mulched Farmland Extraction and Its Application in a Typical Agricultural Region of China Using Sentinel-2 Imagery and Google Earth Engine
Authors: Dong Xinyu , Li Jiaguo , Xu Ning , Lei Junjie , He Zhen , Zhao Limin
Published: November 2024

Plastic-mulching technology has a crucial role to play in modern agriculture by optimizing crop growth environments and enhancing yields. Accurately detecting and mapping the distribution of plastic-mulched farmlands (PMFs) is essential for improving both agricultural management and production efficiency. By analyzing the temporal spectral characteristics of PMFs and crop phenological information, we developed a phenology-based plastic-mulched farmland index (PPMFI). This index, when combined with Sentinel-2 imagery and an automated high-precision extraction process via the Google Earth Engine platform, effectively distinguishes PMFs from other land cover types, especially in complex agricultural landscapes. Validation across areas varying in their background complexity and PMF coverage demonstrated that the proposed PPMFI consistently achieves an overall accuracy rate that exceeds 90%, showcasing its robust performance and significantly outperforming other comparative extraction methods. Applying the PPMFI to the Yudong agricultural region of Henan Province, China, further confirmed its capability for large-scale PMF monitoring, thereby offering critical technical support for sustainable agricultural management and environmental protection.
Development, Analysis, and Determination of Pharmacokinetic Properties of a Solid SMEDDS of Voriconazole for Enhanced Antifungal Therapy
Authors: Dewangan Hitesh Kumar , Sharma Rajiv , Shah Kamal , Alam Perwez
Published: November 2024

Background: Voriconazole is an antifungal drug, which is classified under Bio-Classification System-II and has low water solubility (0.71 mg/mL) and high permeability. Hardly any endeavors have been made to increase the bioavailability of voriconazole. Objective: To develop and evaluate a solid SMEDDS (self-microemulsifying drug delivery system) for antifungal activity. Methods: Based on solubility studies of Labrafil-M 1994 CS (oil), Cremophor-RH 40 (a surfactant) and Transcutol-HP (a co-surfactant) were selected as components of the SMEDDS and a pseudo-ternary phase diagram was prepared. Thereafter, the oil, surfactant, and co-surfactant were mixed with altered weight ratios (1:1/1:2/2:1) and evaluated through various in vitro, in vivo analyses. Results: The particle size of the optimized formulation was observed to be 19.04 nm and the polydispersity index (PDI) value was found to be 0.162 with steady-state zeta potential. The optimized liquid SMEDDS was converted into a solid SMEDDS. Various adsorbents, such as Aerosil-200, Avicel-PH101, Neusilin-US2, and Neusilin UFL2 were screened to better detect the oil-absorbing capacity and flow properties of the powder. Neusilin UFL2 was selected as an adsorbent due to its better oil-absorbing capacity. DSC, X-ray diffraction, and dissolution studies were carried out to characterize the formulation. Further, the Pharmacokinetic profile was also studied in Wistar rats and the Cmax, tmax, and AUC0→t were calculated. The Cmax and AUC0→t plasma concentration is considerably better for the SMEDDS than for the pure drug and marketed formulation. Conclusions: This investigation clearly reveals the potential of developing a solid SMEDDS for candidiasis and invasive aspergillosis treatment, with better efficacy as compared to the commercially available marketed formulation.
Spin(8,C)-Higgs Bundles and the Hitchin Integrable System
Authors: Antón-Sancho Álvaro
Published: November 2024

Let M(Spin(8,C)) be the moduli space of Spin(8,C)-Higgs bundles over a compact Riemann surface X of genus g≥2. This admits a system called the Hitchin integrable system, induced by the Hitchin map, the fibers of which are Prym varieties. Moreover, the triality automorphism of Spin(8,C) acts on M(Spin(8,C)), and those Higgs bundles that admit a reduction in the structure group to G2 are fixed points of this action. This defines a map of moduli spaces of Higgs bundles M(G2)→M(Spin(8,C)). In this work, the action of triality automorphism is extended to an action on the Hitchin integrable system associated with M(Spin(8,C)). In particular, it is checked that the map M(G2)→M(Spin(8,C)) is restricted to a map at the level of the Prym varieties induced by the Hitchin map. Necessary and sufficient conditions are also provided for the Prym varieties associated with the moduli spaces of G2 and Spin(8,C)-Higgs bundles to be disconnected. Finally, some consequences are drawn from the above results in relation to the geometry of the Prym varieties involved.
IMITASD: Imitation Assessment Model for Children with Autism Based on Human Pose Estimation
Authors: Said Hany , Mahar Khaled , Sorour Shaymaa , Elsheshai Ahmed , Shaaban Ramy , Hesham Mohamed , Khadr Mustafa , Mehanna Youssef , Basha Ammar , Maghraby Fahima
Published: November 2024

Autism is a challenging brain disorder affecting children at global and national scales. Applied behavior analysis is commonly conducted as an efficient medical therapy for children. This paper focused on one paradigm of applied behavior analysis, imitation, where children mimic certain lessons to enhance children’s social behavior and play skills. This paper introduces IMITASD, a practical monitoring assessment model designed to evaluate autistic children’s behaviors efficiently. The proposed model provides an efficient solution for clinics and homes equipped with mid-specification computers attached to webcams. IMITASD automates the scoring of autistic children’s videos while they imitate a series of lessons. The model integrates two core modules: attention estimation and imitation assessment. The attention module monitors the child’s position by tracking the child’s face and determining the head pose. The imitation module extracts a set of crucial key points from both the child’s head and arms to measure the similarity with a reference imitation lesson using dynamic time warping. The model was validated using a refined dataset of 268 videos collected from 11 Egyptian autistic children during conducting six imitation lessons. The analysis demonstrated that IMITASD provides fast scoring, takes less than three seconds, and shows a robust measure as it has a high correlation with scores given by medical therapists, about 0.9, highlighting its effectiveness for children’s training applications.
Estimating Asset Pricing Models in the Presence of Cross-Sectionally Correlated Pricing Errors
Authors: Kim Hyuksoo , Kim Saejoon
Published: November 2024

In this study, we propose an adversarial learning approach to the asset pricing model estimation problem which aims to find estimates of factors and loadings that capture time-series covariations while minimizing the worst-case cross-sectional pricing errors. The proposed estimator is defined by a novel min-max optimization problem in which finding a solution is known to be difficult. This contrasts with other related estimators that admit a well-defined analytic solution but do not effectively account for correlations among the pricing errors. To this end, we propose an approximate algorithm based on the alternating optimization procedure and empirically demonstrate that our proposed adversarial estimation framework outperforms other existing factor models, especially when the explanatory power of the pricing model is limited.
Machine Learning-Enhanced Fabrication of Three-Dimensional Co-Pt Microstructures via Localized Electrochemical Deposition
Authors: Zhang Yangqianhui , Zhu Zhanyun , Yang Huayong , Han Dong
Published: November 2024

This paper presents a novel method for fabricating three-dimensional (3D) microstructures of cobalt–platinum (Co-Pt) permanent magnets using a localized electrochemical deposition (LECD) technique. The method involves the use of an electrolyte and a micro-nozzle to control the deposition process. However, traditional methods face significant challenges in controlling the thickness and uniformity of deposition layers, particularly in the manufacturing of magnetic materials. To address these challenges, this paper proposes a method that integrates machine learning algorithms to optimize the electrochemical deposition parameters, achieving a Co:Pt atomic ratio of 50:50. This optimized ratio is crucial for enhancing the material’s magnetic properties. The Co-Pt microstructures fabricated exhibit high coercivity and remanence magnetization comparable to those of bulk Co-Pt magnets. Our machine learning framework provides a robust approach for optimizing complex material synthesis processes, enhancing control over deposition conditions, and achieving superior material properties. This method opens up new possibilities for the fabrication of 3D microstructures with complex shapes and structures, which could be useful in a variety of applications, including micro-electromechanical systems (MEMSs), micro-robots, and data storage devices.
Fuzzy Logic Controller for Power Control of an Electric Arc Furnace
Authors: Ghiormez Loredana , Panoiu Manuela , Panoiu Caius
Published: November 2024

Electric Arc Furnaces (EAFs) are widely used in the steel manufacturing industry to melt scrap steel by employing a large number of electric arcs. EAFs play an important role in ensuring the efficient production of steel. However, their nonlinear and variable load characteristics have a significant impact on power quality. Because the active power of an electric arc depends on its length, a system for controlling the electrode positions is necessary. This paper presents a control system based on a fuzzy logic controller for the active power control of an electric arc furnace. Individual simulation scenarios were chosen with both reference values and the process taken into consideration. The reference, constant value, step variation, and the sequence of step variation were investigated, as well as step disturbances and the sequence of step disturbances from the viewpoint of the process. Furthermore, the procedure of changing the tap on a transformer was investigated. The proposed solution minimizes the time required for charge elaboration, but the main benefit is that there are no additional costs in the implementation process because the installation remains identical, with the only changes being improvements to soft control management.
The Influence of the Ratio of Circumference to Cross-Sectional Area of Tensile Bars on the Fatigue Life of Additive Manufactured AISI 316L Steel
Authors: Ferlič Luka , Jerenec Filip , Šercer Mario , Drstvenšek Igor , Gubeljak Nenad
Published: November 2024

The static and dynamic loading capacities of components depend on the stress level to which the material is exposed. The fatigue behavior of materials manufactured using additive technology is accompanied by a pronounced scatter between the number of cycles at the same stress level, which is significantly greater than the scatter from a material with the same chemical composition, e.g., AISI 316L, but produced by rolling or forging. An important reason lies in the fact that fatigue cracks are initiated almost always below the material surface of the loaded specimen. Thus, in the article, assuming that a crack will always initiate below the surface, we analyzed the fatigue behavior of specimens with the same bearing cross section but with a different number of bearing rods. With a larger number of rods, the circumference around the supporting part of the rods was 1.73 times larger. Thus, experimental fatigue of specimens with different sizes showed that the dynamic loading capacity of components with a smaller number of bars is significantly greater and can be monitored by individual stress levels. Although there are no significant differences in loading capacity under static and low-cycle loading of materials manufactured with additive technologies, in high-cycle fatigue it has been shown that the ratio between the circumference and the loading cross section of tensile-loaded rods plays an important role in the lifetime. This finding is important for setting a strategy for manufacturing components with additive technologies. It shows that a better dynamic loading capacity can be obtained with a larger loading cross section.
Metabolic Effects of Loquat Juice (Eriobotrya japonica Lindl Mkarkeb Variety) on Lipid Homeostasis, Liver Steatosis, and Oxidative Stress in Hyperlipidemic Mice Fed a High-Fat–High-Fructose Diet
Authors: Mokhtari Imane , Aljutaily Thamer , Aljumayi Huda , Radhi Khadija S. , Almutairi Abdulkarim S. , Barakat Hassan , Khalifa Ibrahim , Amrani Souliman , Harnafi Hicham
Published: November 2024

Background: Loquat fruit is consumed for its flavorful taste and a rich array of health-promoting compounds like phenolics, flavonoids, and carotenoids. This study aimed at the biochemical characterization of fresh juice from the Moroccan Mkarkeb variety of loquat and evaluating its effects on lipid homeostasis and liver steatosis in hyperlipidemic mice. Methods: The biochemical characterization followed AOAC methods. In vivo study involved hyperlipidemic mice fed a high-fat, high-fructose diet for 6 weeks and treated with loquat juice at 3.5 and 7 mL kg−1 or fenofibrate at 4 mg·kg−1. The concentrations of lipids in plasma, liver, adipose tissue, feces, and bile and blood glucose levels were quantified. Liver steatosis was visually examined and confirmed histologically, and liver injury markers (AST, ALT, ALP, LDH, and TB) were measured. Liver oxidative stress was assessed by measuring MDA content and antioxidative enzyme activities. Results: Our findings indicate that fresh loquat juice is poor in fat and protein and contains moderate sugars with a low energy value (40.82 ± 0.25 kcal/100 g). It is also rich in minerals, vitamin C, phenolic acids, flavonoids, and carotenoids. The juice effectively restored lipid metabolism by enhancing reverse cholesterol transport and lowering LDL-cholesterol, triglycerides, and the atherogenic index. The studied juice decreases blood glucose and prevents weight gain and lipid accumulation in the liver and adipose tissue. The juice prevents lipotoxicity-induced liver injury, corrects toxicity markers, and improves the liver’s morphological and histological structures. It also reduces oxidative stress by lowering MDA and activating SOD and catalase. Conclusions: The juice holds high nutritional and medicinal value, potentially preventing lipid disorders and cardiovascular issues.
Aging and Pathological Conditions Similarity Revealed by Meta-Analysis of Metabolomics Studies Suggests the Existence of the Health and Age-Related Metapathway
Authors: Lokhov Petr G. , Balashova Elena E. , Maslov Dmitry L. , Trifonova Oxana P. , Archakov Alexander I.
Published: November 2024

Background: The incidence of many diseases increases with age and leads to multimorbidity, characterized by the presence of multiple diseases in old age. This phenomenon is closely related to systemic metabolic changes; the most suitable way to study it is through metabolomics. The use of accumulated metabolomic data to characterize this phenomenon at the system level may provide additional insight into the nature and strength of aging–disease relationships. Methods: For this purpose, metabolic changes associated with human aging and metabolic alterations under different pathological conditions were compared. To do this, the published results of metabolomic studies on human aging were compared with data on metabolite alterations collected in the human metabolome database through metabolite set enrichment analysis (MSEA) and combinatorial analysis. Results: It was found that human aging and pathological conditions involve the set of the same metabolic pathways with a probability of 99.96%. These data show the high identity of the aging process and the development of diseases at the metabolic level and allow to identify the set of metabolic pathways reflecting age-related changes closely associated with health. Based on these pathways, a metapathway was compiled, changes in which are simultaneously associated with health and age. Conclusions: The knowledge about the strength of the convergence of aging and pathological conditions has been supplemented by the rigor evidence at the metabolome level, which also made it possible to outline the age and health-relevant place in the human metabolism.
The Ocular Microbiome: Micro-Steps Towards Macro-Shift in Targeted Treatment? A Comprehensive Review
Authors: Trojacka Ewelina , Izdebska Justyna , Szaflik Jacek , Przybek-Skrzypecka J.
Published: November 2024

A healthy ocular surface is inhabited by microorganisms that constitute the ocular microbiome. The core of the ocular microbiome is still a subject of debate. Numerous culture-dependent and gene sequencing studies have revealed the composition of the ocular microbiome. There was a confirmed correlation between the ocular microbiome and ocular surface homeostasis as well as between ocular dysbiosis and pathologies such as blepharitis, microbial keratitis, and conjunctivitis. However, the role of the ocular microbiome in the pathogenesis and treatment of ocular surface diseases remains unclear. This article reviews available data on the ocular microbiome and microbiota, their role in maintaining ocular homeostasis, and the impact of dysbiosis on several ophthalmic disorders. Moreover, we aimed to discuss potential treatment targets within the ocular microbiota.
Evaluation of the Effect of pH and Concentration of Calcium and Sulfate Ions on Coal Flotation
Authors: González-Ibarra Adrián A. , Dávila-Pulido Gloria I. , González-Bonilla Blanca R. , Charles Danay A. , Ríos-Hurtado Jorge Carlos , Salinas-Rodríguez Armando
Published: November 2024

The presence of calcium sulfate in the process water during the coal flotation greatly influences the recovery and selectivity of the separation. The concentrations of calcium and sulfate ions modify mineral hydrophobicity by altering surface properties resulting in depression or activation of the mineral species. An investigation to evaluate the statistical significance of the effect of the pH and concentration of calcium and sulfate ions on coal flotation was carried out; for this purpose, a 23 factorial design was implemented. A p-value < 0.05 was determined for the effect of calcium and sulfate ion concentrations, indicating that it is statistically significant. The interactions between factors (pH × calcium, pH × sulfate, calcium × sulfate and pH × calcium × sulfate) are also statistically significant, but the interaction between the concentration of calcium and sulfate ions has a notable influence according to the F statistic value. Employing 800 and 1920 mg/L of calcium and sulfate ions as experimental conditions yields a recovery of 90.4% with a concentrate containing 13% ash.
Sintering Behavior of Molybdenite Concentrate During Oxidation Roasting Process in Air Atmosphere: Influences of Roasting Temperature and K Content
Authors: Liu Jiangang , Wang Lu , Wu Guohuan
Published: November 2024

Sintering is a common phenomenon, which often takes place during the oxidation roasting process of molybdenite concentrate in multiple-hearth furnaces. The occurrence of sintering phenomena has detrimental effects on the product quality and the service life of the furnace. In this work, the influence of two key factors (roasting temperature and K content) on the sintering behavior is investigated using molybdenite concentrate as the raw material. Different technologies such as XRD, FESEM-EDS, and phase diagrams are adopted to analyze the experimental data. The results show that the higher the roasting temperature is, the greater the mass loss and the more serious the sintering degree will be. The results also show that with the increase in K content, the mass loss of the raw material is first increased and then decreased, while its sintering degree is still gradually increased. The sintering products obtained during the oxidation roasting process are often tightly combined with the bottom of the used crucible with a smooth and dense surface structure, while their internal microstructures are very complicated, which not only includes numerous MoO3 species, but also unoxidized MoS2, Mo sub-oxide, SiO2, and a variety of molybdates. Among them, both MoO3 and molybdates can be easily dissolved into the ammonia solution, leading to a residue mainly composed of SiO2 and CaMoO4. This study also finds that the sintering phenomenon is caused by the increase in local temperature and the formation of various low-melting-point eutectics. It is suggested that decreasing the roasting temperature and K content, especially the K content, are effective methods for reducing the sintering degree of molybdenite concentrate during the oxidation roasting process.
Emulsifiers: Their Influence on the Rheological and Texture Properties in an Industrial Chocolate
Authors: Pombal Maria , Marcet Ismael , Rendueles Manuel , Diaz Mario
Published: November 2024

The complexity of the chocolate matrix leads to it having characteristic rheological properties that may pose difficulties for its industrial manufacture. Many factors influence the flow behaviour of chocolates, such as raw materials, the amount of fat, the moisture content, particle-size distribution, the concentration of emulsifiers, or manufacturing conditions, among others. This study focusses on the rheological properties of an industrially manufactured chocolate with a 48% cocoa content, and the effect caused by the addition of two emulsifiers (soya lecithin and polyglycerol polyricinoleate (PGPR)) on the rheological properties. In the case of lecithin, a clear effect has been observed on the plastic viscosity and the yield stress. Plastic viscosity decreases until a concentration of 0.6% lecithin is reached, and thereafter remains relatively constant, while yield stress increases over the studied range. This effect is not observed when PGPR is used as the emulsifying agent. In this case, a small concentration of PGPR decreases the yield stress. Thixotropy was determined using the Casson model, and its behaviour was found to be similar to that of plastic viscosity with respect to changes in the PGPR and lecithin concentrations. Textural determinations were also carried out, relating the rheology characteristics to the texturometry.