bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Hybrid Systems by Integrating an Adsorption Process with Natural Zeolite and/or Palygorskite into the Electrocoagulation Treatment of Sanitary Landfill Leachate
Authors: Genethliou Christiana , Triantaphyllidou Irene-Eva , Chatzitheodorou Dimitrios , Tekerlekopoulou Athanasia G. , Vayenas Dimitris V.
Published: May 2023

The effectiveness of a hybrid approach comprising electrocoagulation (EC) and adsorption (AD) (using natural zeolite and/or palygorskite) processes to treat raw sanitary landfill leachate (SLL) was investigated in terms of color, dissolved chemical oxygen demand (d-COD), nitrate nitrogen (NO3−-N) and ammonium nitrogen (NH4+-N) removal. Optimal EC conditions were found with a current density of 30 mA cm−2, Fe electrode material and pH 8. Implementation of the AD process using zeolite (ADzeo) as pre- or post-treatment for EC significantly increased the NH4+-N removal efficiency. The ADzeo-EC sequential treatment showed considerably higher color removal compared to the EC-ADzeo sequential treatment and was therefore determined to be the optimal sequential treatment. Integration of the AD process using palygorskite (ADpal) into the first or middle stage of the ADzeo-EC treatment system enhanced the overall NO3−-N removal efficiency. The hybrid ADzeo-ADpal-EC treatment system exhibited the highest simultaneous removal efficiencies of color, d-COD, NO3−-N and NH4+-N, corresponding to 95.06 ± 0.19%, 48.89 ± 0.89%, 68.38 ± 0.93% and 78.25 ± 0.61%, respectively. The results of this study indicate that the ADzeo-ADpal-EC hybrid system is a promising and efficient approach for treating raw landfill leachate.
The Impacts of China’s Resident Tourism Subsidy Policy on the Economy and Air Pollution Emissions
Authors: Zheng Leyi , Liu Junfeng , Yang Qiong , Wang Yuqing , Liu Ying , Hu Xiurong , Hu Jianying , Wan Yi , Wang Xuejun , Ma Jianmin , Wang Xilong , Tao Shu
Published: May 2023

Currently, tourism is an important contributor to the Chinese economy. The Chinese government issued Several Opinions of the State Council on Promoting the Reform and Development of Tourism and Several Opinions of the General Office of the State Council on Further Promoting Tourism Investment and Consumption, which are aimed at promoting tourism development. In this study, we use a multiregional and multisectoral computable general equilibrium model (CGE model) to simulate the effects of different levels of resident tourism subsidy policies on the economy and environment in China. Our analysis shows that tourism subsidies are beneficial to economic growth and support the transition to a low-carbon society. In addition, resident tourism subsidy policy has a positive effect on the national emission reduction of CO2, CO, NOX, PM2.5, and SO2. At the regional level, more significant emission reduction potential is present in provinces with more energy consumption and a more developed heavy industry, such as Shandong, Guizhou, and Inner Mongolia. Therefore, this study indicates that resident tourism subsidies can be an effective policy suggestion to promote the transition to a green society and air pollutant emission reduction.
Think Tank Innovation-Driven Knowledge Service Ecosystems: A Conceptual Framework and Case Study Application
Authors: Li Yichao , Shen Jing , Cetindamar Dilek
Published: May 2023

By drawing on ecosystem and innovation-driven development theories, the aim of this paper is to increase our understanding of their application to think tanks. The composition, structure, and features of the knowledge service ecosystem of think tanks are conceptualized via a literature review. The model developed from this was validated by analyzing the data collected from 25 think tanks in the United States (US). The model constructed provides a reference for the sustainable and healthy development of knowledge services in think tanks and an innovation-driven development perspective for researchers interested in their innovation ecosystem dynamics. The intake of talent forms a necessary part of think tank construction, but, more importantly, this continuous intake is a crucial driving force for their sustainable development. This paper suggests that an increasing focus on talents in knowledge service ecosystems can lead to and assist in establishing innovative think tanks in many countries.
Rheological and Fatigue Characteristics of Asphalt Mastics and Mixtures Containing Municipal Solid Waste Incineration (MSWI) Residues
Authors: Xu Ling , Du Yinfei , Loprencipe Giuseppe , Moretti Laura
Published: May 2023

The large-scale implementation of municipal solid waste incineration (MSWI) has put great pressure on waste management and environmental protection. Road construction engineering has also been confronted with the challenges of the heavy consumption of non-renewable mineral resources. Therefore, we evaluated the feasibility of recycling and reusing MSWI residue as an alternative to limestone filler (LF) in transport infrastructure. We investigated the rheological characteristics and fatigue performance of asphalt mastics and mixtures containing MSWI residue. Firstly, a particle size analyzer and environmental scanning electron microscope were adopted to characterize the particle distribution and surface micromorphology of the investigated fillers, respectively. Then, tests for determining the steady shear viscosity and multiple-stress creep recovery were conducted to evaluate the high-temperature rheology of five asphalt mastics. Meanwhile, we used Burgers models with fitting parameters to describe the classic creep recovery measurements and viscoelastic responses. The wheel-tracking test revealed the rutting resistance, and the linear amplitude sweep (LAS) and time sweep tests were combined to investigate the fatigue performances of the five asphalt mastics. A dynamic creep test identified the fatigue life of the asphalt mixtures according to the flow number index. Finally, statistical analysis was conducted to identify the correlations between the rheological and fatigue properties of the mastics and mixtures (R2 over 0.87 and 0.78, respectively). Since the fatigue life predictions for the asphalt mastic decreased by over 42.9% according to the MSWI residue/LF volume ratio, the results of the correlations could improve pavement designs. The substitution of the mineral filler in asphalt mixtures with MSWI residue could be a sustainable strategy for the road construction sector.
Energy and Exergy Analyses of a PWR-Type Nuclear Power Plant Coupled with an ME-TVC-MED Desalination System
Authors: Triki Zakaria , Menasri Rabah , Bouaziz Mohamed Najib , Tahraoui Hichem , Kebir Mohammed , Amrane Abdeltif , Zhang Jie , Mouni Lotfi
Published: May 2023

Electricity–water cogeneration power plants are an important tool for advancing sustainable water treatment technologies because they provide a cost-effective and environmentally friendly solution for meeting the energy and water needs of communities. By integrating power and water production, these technologies can reduce carbon emissions and help mitigate the impact of climate change. This work deals with the energy and exergy analysis of a cogeneration plant for electrical power generation and water desalination using real operational data. The power side is a pressurized water reactor (PWR) nuclear power plant (NPP), while the desalination side is a multi-effect distillation (MED) system with a thermo-vapor compressor (TVC) plant coupled with a conventional multi-effect plant (ME-TVC-MED). A mathematical model was implemented in MATLAB software and validated through a comparison with previously published research. The exergy analysis was carried out based on the second law of thermodynamics to evaluate the irreversibility of the plant and the subsystems. In this study, the components of the sub-systems were analyzed separately to identify and quantify the component that has a high loss of energy and exergy. According to the energy and exergy analyses, the highest source of irreversibility occurs in the reactor core with 50% of the total exergy destruction. However, turbines, steam generators, and condensers also contribute to energy loss. Further, the thermodynamic efficiency of the cogeneration plant was obtained as 35.38%, which is more effective than other systems. In the ME-TVC-MED desalination unit, the main sources of energy losses are located in the evaporators and the thermo-compressor (about 50% and 36%, respectively). Moreover, the exergetic efficiency of the ME-TVC-MED unit was found to be low at 6.43%, indicating a high degree of technical inefficiency in the desalination process. Therefore, many opportunities exist to improve the performance of the cogeneration system.
Experimental Study on the Seismic Behavior of a Modified Adobe-Brick-Masonry Composite Wall with a Wooden-Construction Center Column
Authors: Wang Haoran , Yuan Kang , Zhang Songlin , Guo Junlin
Published: May 2023

Damage to adobe constructions might occur due to a long wall and a lack of effective restraint in the middle of the wall, causing it to collapse under an earthquake. Aiming at these problems, a technology for improving the seismic performance of a modified adobe-brick-masonry composite wall with a wooden-construction center column is proposed. It uses modified mud, a wooden center column, steel-wire mesh, and nylon ropes to reinforce the wall. On this basis, four specimens of composite wall and one specimen of modified adobe wall were subjected to proposed quasistatic, cyclic in-plane loading tests to study their failure modes and seismic performance indicators. The results show that the failure modes of all walls were shear failure. The difference is that the modified adobe wall had horizontal cracks in the middle, whereas the composite walls were largely intact. Moreover, the composite walls relied on the modified mud to improve the seismic bearing capacity of each wall. They relied on the center column and the tie materials to form a second line of defense that would increase the wall ductility and collapse residual area. As a result, the phenomenon that caused wall damage and stiffness degradation was lessened.
Correction: Latha, D.S.; Samanchuen, T. Development of Reference Process Model and Reference Architecture for Pharmaceutical Cold Chain. Sustainability 2023, 15, 3935
Authors: Latha Divya Sasi , Samanchuen Taweesak
Published: May 2023

The authors would like to make the following corrections about the published paper [...]
Realizing Benefit Sharing through Reasonable Land Compensation in the Sustainable Development of Water Resources: Two Case Studies in China
Authors: Sun Haibing , Li Xuan , Duan Yuefang , Zhang Ningjing
Published: May 2023

The existence of benefit distribution unfairness may lead to problems such as resettlement conflicts, which have become the bottleneck of sustainable development of water resources in many countries. Exploring and establishing equitable benefit sharing systems are the resolving approach, but there is still the lack of quantitative analysis tools for benefit distribution. From the perspective of benefit sharing, this study designs specific quantitative methods to determine land compensation prices that migrants deserve and makes a case analysis of two projects in China. Results suggest the following: (1) Fair compensation calculated by the input dividend method is the product of the proportion of agricultural land investment and the net income of the project, while the value summation method takes the sum of the agricultural land value, social security value and average value-added distribution as the compensation price. (2) The cases demonstrate the feasibility of the proposed methods. (3) Current policy compensation is lower than the calculated compensation, and there are insufficient migrants participating in benefit sharing in China. By referring to the estimated value of the two methods, governments or development enterprises can reasonably improve the compensation standard or provide additional follow-up support to increase the welfare of migrants, which is expected to achieve a relatively balanced allocation of benefits and realize a win-win situation.
A Critical Review of Studies on Coopetition in Educational Settings
Authors: Chen Minwei , Lv Cixian , Wang Xinghua , Li Linlin , Yang Peijin
Published: May 2023

The benefits and limitations of utilizing collaborative and competitive activities within and between groups to facilitate learning are well known. Typically, these two concepts are viewed as mutually exclusive approaches, where one is favored over the other in the classroom. However, utilizing an approach that takes advantage of the strengths of both while minimizing each one’s weaknesses, could greatly enhance students’ learning. This approach is called coopetition. Because of the dominance of collaboration and competition, the number of studies investigating coopetition in learning environments is rather limited. Therefore, this article reviews the extant studies using a coopetitive approach to provide a fuller understanding of this concept. Altogether, 33 articles were retrieved and analyzed using a grounded constant-comparative approach. As a result of the analysis, three categories of research topics emerged: (a) organization of coopetition, including zero-sum coopetition and social comparison coopetition, (b) medium and coopetition, including coopetition conducted in conventional face-to-face settings and computer-mediated settings, and (c) application of coopetition in education, which covers multiple areas such as cognitive, affective, and social domains, as well as educational management. The review discusses each category in detail, highlighting implications for future educational research and practice.
Will World Cultural Heritage Sites Boost Economic Growth? Evidence from Chinese Cities
Authors: Zeng Zhixin , Wang Xiaojun
Published: May 2023

Cultural heritage is closely related to the economy. However, most studies focus on the relationship between the cultural heritage and tourism economy, instead of on the overall economy. This paper estimated the effect of the World Cultural Heritage(s) (WCH) acquisition on economic growth in 242 Chinese cities from 2004 to 2017, based on multiple variations of the difference-in-differences method. Our results show that the WCH acquisition can boost economic growth in local cities. In addition, research and development investments, appearance patents, and exports are three plausible channels for the WCH acquisition to spur cities’ economic growth. Connecting to high-speed rail is not necessary for a city to gather economic benefits from the WCH acquisition. Being a smart city can increase the economic enhancement capacity of the WCH acquisition.
Modelling the Slovenian Wood Industry’s Response to the Greenhouse Gas Paris Agreement and the EU “Fit for 55” Green Transition Plan
Authors: Schau Erwin M. , Gavrić Igor , Šušteršič Iztok , Prelovšek Niemelä Eva , Dávid Balázs , Pečnik Jaka Gašper , DeVallance David B. , Tavzes Črtomir
Published: May 2023

Almost 200 nations, including the European Union, have signed the Paris Agreement that aims to limit the temperature rise to 1.5 °C above pre-industrial levels by reducing greenhouse gas (GHG) emissions. To meet this target, a significant decrease in GHG emissions by 2030 and net zero by 2050 is necessary. To determine the role of wood products in achieving a 55% reduction in GHG emissions by 2030 compared with 1990 levels, we investigated Slovenia’s potential, which has close to 60% forested areas. Therefore, the country could use wood-based products to achieve the agreed-upon climate goals. Nevertheless, uncertainties remain regarding the extent to which increased tree harvesting, local manufacturing, and the utilization of wood products can aid in substituting fossil-derived materials and reducing GHG emissions. A new model was constructed to increase the understanding of the wood products’ (throughout the forest-based industrial ecosystem, incl. construction) potential contribution to reaching the stated emissions targets. Using this linear programming (LP) mathematical optimisation model and carbon footprint calculations based on life cycle assessment methods, a wood flow distribution, the financial investment needed to process these quantities, and the GHG emissions produced and/or saved were calculated. The findings stipulated that Slovenia has the potential to achieve 55 % less GHG emissions by 2030 by expanding logging to at least 3 million m3 and converting the timber to a larger amount of long service-life wooden items made (and utilised) within the country. Such products accumulate carbon for a long time and decrease the need for materials that cause higher GHG emissions. Concomitantly, a better appreciation of the substitution effects in official carbon accounting would be needed. Moreover, to materialize the potential decrease in emissions would require Slovenia’s construction sector to replace fossil- and mineral-based materials with lignocellulosic products, and to increase the capacity to utilize lower-quality wood in high added value applications, which would require significant investment. This paper offers a comprehensive analysis of diverse optimisation outcomes obtained from the investigation into climate action through the use of wood products in Slovenia.
Radius Results for Certain Strongly Starlike Functions
Authors: Saliu Afis , Jabeen Kanwal , Xin Qin , Tchier Fairouz , Malik Sarfraz Nawaz
Published: May 2023

This article comprises the study of strongly starlike functions which are defined by using the concept of subordination. The function φ defined by φ(ζ)=(1+ζ)λ, 0<λ<1 maps the open unit disk in the complex plane to a domain symmetric with respect to the real axis in the right-half plane. Using this mapping, we obtain some radius results for a family of starlike functions. It is worth noting that all the presented results are sharp.
β-Glucan Induces Training Immunity to Promote Antiviral Activity by Activating TBK1
Authors: Wang Guolei , Li Zhiqiang , Tian Mingfu , Cui Xianghua , Ma Jun’e , Liu Siyu , Ye Chenglin , Yuan Li , Qudus Muhammad Suhaib , Afaq Uzair , Wu Kailang , Liu Xinghui , Zhu Chengliang
Published: May 2023

Many studies have shown that β-glucan induces a trained immune phenotype in innate immune cells to defend against bacterial and fungal infections. The specific mechanism involves cellular metabolism and epigenetic reprogramming. However, it is unclear whether β-glucan plays a role in antiviral infection. Therefore, this study investigated the role of trained immunity induced by Candida albicans and β-glucan in antiviral innate immunity. It showed that C. albicans and β-glucan promoted the expression of interferon-β (IFN-β) and interleukin-6 (IL-6) in mouse macrophages triggered by viral infection. In addition, β-glucan pretreatment attenuated the pathological damage induced by the virus in mouse lungs and promoted the expression of IFN-β. Mechanistically, β-glucan could promote the phosphorylation and ubiquitination of TANK Binding Kinase 1 (TBK1), a key protein of the innate immune pathway. These results suggest that β-glucan can promote innate antiviral immunity, and this bioactive material may be a potential therapeutic target for antiviral treatment.
Clinical Features of COVID-19 in Pediatric Rheumatic Diseases: 2020–2022 Survey of the Pediatric Rheumatology Association of Japan
Authors: Wakiguchi Hiroyuki , Kaneko Utako , Sato Satoshi , Imagawa Tomoyuki , Narazaki Hidehiko , Miyamae Takako
Published: May 2023

Coronavirus disease 2019 (COVID-19) in children can be compounded by concurrent diseases and immunosuppressants. For the first time, we aimed to report the clinical features of concurrent COVID-19 and pediatric rheumatic disease (PRD) in Japan. Pediatric Rheumatology Association of Japan members were surveyed between 1 April 2020 and 31 August 2022. Outcome measurements included the clinical features of concurrent PRD and COVID-19. Questionnaire responses were obtained from 38 hospitals. Thirty-one hospitals (82%) had children with PRD and COVID-19. The female-to-male ratio in these children (n = 156) was 7:3, with half aged 11–15 years. The highest proportion of children with PRD and COVID-19 was accounted for by juvenile idiopathic arthritis (52%), followed by systemic lupus erythematosus (24%), juvenile dermatomyositis (5%), scleroderma (4%), and Takayasu arteritis (3%). Of children with PRD, a significant majority (97%) were found to be asymptomatic (10%) or presented with mild symptoms (87%) of the COVID-19 infection. No severe cases or deaths were observed. Regarding the use of glucocorticoids, immunosuppressants, or biologics for PRD treatment before COVID-19, no significant difference was found between asymptomatic/mild and moderate COVID-19 in children with PRD. Therefore, COVID-19 is not a threat to children with PRD in Japan.
Porcine Circovirus Modulates Swine Influenza Virus Replication in Pig Tracheal Epithelial Cells and Porcine Alveolar Macrophages
Authors: Burgher Pulgaron Yaima , Provost Chantale , Pesant Marie-Jeanne , Gagnon Carl A.
Published: May 2023

The pathogenesis of porcine circovirus type 2b (PCV2b) and swine influenza A virus (SwIV) during co-infection in swine respiratory cells is poorly understood. To elucidate the impact of PCV2b/SwIV co-infection, newborn porcine tracheal epithelial cells (NPTr) and immortalized porcine alveolar macrophages (iPAM 3D4/21) were co-infected with PCV2b and SwIV (H1N1 or H3N2 genotype). Viral replication, cell viability and cytokine mRNA expression were determined and compared between single-infected and co-infected cells. Finally, 3′mRNA sequencing was performed to identify the modulation of gene expression and cellular pathways in co-infected cells. It was found that PCV2b significantly decreased or improved SwIV replication in co-infected NPTr and iPAM 3D4/21 cells, respectively, compared to single-infected cells. Interestingly, PCV2b/SwIV co-infection synergistically up-regulated IFN expression in NPTr cells, whereas in iPAM 3D4/21 cells, PCV2b impaired the SwIV IFN induced response, both correlating with SwIV replication modulation. RNA-sequencing analyses revealed that the modulation of gene expression and enriched cellular pathways during PCV2b/SwIV H1N1 co-infection is regulated in a cell-type-dependent manner. This study revealed different outcomes of PCV2b/SwIV co-infection in porcine epithelial cells and macrophages and provides new insights on porcine viral co-infections pathogenesis.
Area Wide Monitoring of Plant and Honey Bee (Apis mellifera) Viruses in Blueberry (Vaccinium corymbosum) Agroecosystems Facilitated by Honey Bee Pollination
Authors: Lee Eunseo , Vansia Raj , Phelan James , Lofano Andrea , Smith Adam , Wang Aiming , Bilodeau Guillaume J. , Pernal Stephen F. , Guarna M. Marta , Rott Michael , Griffiths Jonathan S.
Published: May 2023

Healthy agroecosystems are dependent on a complex web of factors and inter-species interactions. Flowers are hubs for pathogen transmission, including the horizontal or vertical transmission of plant-viruses and the horizontal transmission of bee-viruses. Pollination by the European honey bee (Apis mellifera) is critical for industrial fruit production, but bees can also vector viruses and other pathogens between individuals. Here, we utilized commercial honey bee pollination services in blueberry (Vaccinium corymbosum) farms for a metagenomics-based bee and plant virus monitoring system. Following RNA sequencing, viruses were identified by mapping reads to a reference sequence database through the bioinformatics portal Virtool. In total, 29 unique plant viral species were found at two blueberry farms in British Columbia (BC). Nine viruses were identified at one site in Ontario (ON), five of which were not identified in BC. Ilarviruses blueberry shock virus (BlShV) and prune dwarf virus (PDV) were the most frequently detected viruses in BC but absent in ON, while nepoviruses tomato ringspot virus and tobacco ringspot virus were common in ON but absent in BC. BlShV coat protein (CP) nucleotide sequences were nearly identical in all samples, while PDV CP sequences were more diverse, suggesting multiple strains of PDV circulating at this site. Ten bee-infecting viruses were identified, with black queen cell virus frequently detected in ON and BC. Area-wide bee-mediated pathogen monitoring can provide new insights into the diversity of viruses present in, and the health of, bee-pollination ecosystems. This approach can be limited by a short sampling season, biased towards pollen-transmitted viruses, and the plant material collected by bees can be very diverse. This can obscure the origin of some viruses, but bee-mediated virus monitoring can be an effective preliminary monitoring approach.
Successful Bacteriophage-Antibiotic Combination Therapy against Multidrug-Resistant Pseudomonas aeruginosa Left Ventricular Assist Device Driveline Infection
Authors: Racenis Karlis , Lacis Janis , Rezevska Dace , Mukane Laima , Vilde Aija , Putnins Ints , Djebara Sarah , Merabishvili Maya , Pirnay Jean-Paul , Kalnina Marika , Petersons Aivars , Stradins Peteris , Maurins Sandis , Kroica Juta
Published: May 2023

There is considerable interest in the use of bacteriophages (phages) to treat Pseudomonas aeruginosa infections associated with left ventricular assist devices (LVADs). These infections are often challenging to manage due to high rates of multidrug resistance and biofilm formation, which could potentially be overcome with the use of phages. We report a case of a 54-year-old man with relapsing multidrug-resistant P. aeruginosa LVAD driveline infection, who was treated with a combination of two lytic antipseudomonal phages administered intravenously and locally. Treatment was combined with LVAD driveline repositioning and systemic antibiotic administration, resulting in a successful outcome with clinical cure and eradication of the targeted bacteria. However, laboratory in vitro models showed that phages alone could not eradicate biofilms but could prevent biofilm formation. Phage-resistant bacterial strains evolved in biofilm models and showed decreased susceptibility to the phages used. Further studies are needed to understand the complexity of phage resistance and the interaction of phages and antibiotics. Our results indicate that the combination of phages, antibiotics, and surgical intervention can have great potential in treating LVAD-associated infections. More than 21 months post-treatment, our patient remains cured of the infection.
Natural Products and Derivatives as Potential Zika virus Inhibitors: A Comprehensive Review
Authors: Pereira Rosângela Santos , Santos Françoise Camila Pereira , Campana Priscilla Rodrigues Valadares , Costa Vivian Vasconcelos , de Pádua Rodrigo Maia , Souza Daniele G. , Teixeira Mauro Martins , Braga Fernão Castro
Published: May 2023

Zika virus (ZIKV) is an arbovirus whose infection in humans can lead to severe outcomes. This article reviews studies reporting the anti-ZIKV activity of natural products (NPs) and derivatives published from 1997 to 2022, which were carried out with NPs obtained from plants (82.4%) or semisynthetic/synthetic derivatives, fungi (3.1%), bacteria (7.6%), animals (1.2%) and marine organisms (1.9%) along with miscellaneous compounds (3.8%). Classes of NPs reported to present anti-ZIKV activity include polyphenols, triterpenes, alkaloids, and steroids, among others. The highest values of the selectivity index, the ratio between cytotoxicity and antiviral activity (SI = CC50/EC50), were reported for epigallocatechin gallate (SI ≥ 25,000) and anisomycin (SI ≥ 11,900) obtained from Streptomyces bacteria, dolastane (SI = 1246) isolated from the marine seaweed Canistrocarpus cervicorni, and the flavonol myricetin (SI ≥ 862). NPs mostly act at the stages of viral adsorption and internalization in addition to presenting virucidal effect. The data demonstrate the potential of NPs for developing new anti-ZIKV agents and highlight the lack of studies addressing their molecular mechanisms of action and pre-clinical studies of efficacy and safety in animal models. To the best of our knowledge, none of the active compounds has been submitted to clinical studies.
Foundation of the Belgian Society for Viruses of Microbes and Meeting Report of Its Inaugural Symposium
Authors: Latka Agnieszka , Aertsen Abram , Boeckaerts Dimitri , Blasdel Bob , Ceyssens Pieter-Jan , Garcia-Pino Abel , Gillis Annika , Lavigne Rob , Lima-Mendez Gipsi , Matthijnssens Jelle , Onsea Jolien , Peeters Eveline , Pirnay Jean-Paul , Thiry Damien , Vandenheuvel Dieter , Van Mechelen Els , Venneman Jolien , Verbeken Gilbert , Wagemans Jeroen , Briers Yves
Published: May 2023

The Belgian Society for Viruses of Microbes (BSVoM) was founded on 9 June 2022 to capture and enhance the collaborative spirit among the expanding community of microbial virus researchers in Belgium. The sixteen founders are affiliated to fourteen different research entities across academia, industry and government. Its inaugural symposium was held on 23 September 2022 in the Thermotechnical Institute at KU Leuven. The meeting program covered three thematic sessions launched by international keynote speakers: (1) virus–host interactions, (2) viral ecology, evolution and diversity and (3) present and future applications. During the one-day symposium, four invited keynote lectures, ten selected talks and eight student pitches were given along with 41 presented posters. The meeting hosted 155 participants from twelve countries.
A Booster with a Genotype-Matched Inactivated Newcastle Disease Virus (NDV) Vaccine Candidate Provides Better Protection against a Virulent Genotype XIII.2 Virus
Authors: Hossain Ismail , Subarna Jannatul Ferdous , Kabiraj Congriev Kumar , Begum Jahan Ara , Parvin Rokshana , Martins Mathias , Diel Diego G. , Chowdhury Emdadul Haque , Islam Mohammad Rafiqul , Nooruzzaman Mohammed
Published: May 2023

Newcastle disease (ND) is endemic in Bangladesh. Locally produced or imported live Newcastle disease virus (NDV) vaccines based on lentogenic virus strains, locally produced live vaccines of the mesogenic Mukteswar strain, as well as imported inactivated vaccines of lentogenic strains, are being used in Bangladesh under different vaccination regimens. Despite these vaccinations, frequent outbreaks of ND are being reported in Bangladesh. Here we compared the efficacy of booster immunization with three different vaccines in chickens that had been primed with two doses of live LaSota vaccine. A total of 30 birds (Group A) were primed with two doses of live LaSota virus (genotype II) vaccine at days 7 and 28, while 20 birds (Group B) remained unvaccinated. At day 60, birds of Group A were divided into three sub-groups, which received booster immunizations with three different vaccines; A1: live LaSota vaccine, A2: inactivated LaSota vaccine, and A3: inactivated genotype XIII.2 vaccine (BD-C161/2010 strain from Bangladesh). Two weeks after booster vaccination (at day 74), all vaccinated birds (A1–A3) and half of the unvaccinated birds (B1) were challenged with a genotype XIII.2 virulent NDV (BD-C161/2010). A moderate antibody response was observed after the primary vaccination, which substantially increased after the booster vaccination in all groups. The mean HI titers induced by the inactivated LaSota vaccine (8.0 log2/5.0 log2 with LaSota/BD-C161/2010 HI antigen) and the inactivated BD-C161/2010 vaccine (6.7 log2/6.2 log2 with LaSota/BD-C161/2010 HI antigen) were significantly higher than those induced by the LaSota live booster vaccine (3.6 log2/2.6 log2 with LaSota/BD-C161/2010 HI antigen). Despite the differences in the antibody titers, all chickens (A1–A3) survived the virulent NDV challenge, while all the unvaccinated challenged birds died. Among the vaccinated groups, however, 50% of the chickens in Group A1 (live LaSota booster immunization) shed virus at 5- and 7-days post challenge (dpc), while 20% and 10% of the chickens in Group A2 (inactivated LaSota booster immunization) shed virus at 3 and 5 dpc, respectively, and only one chicken (10%) in Group A3 shed virus at 5 dpc. In conclusion, the genotype-matched inactivated NDV booster vaccine offers complete clinical protection and a significant reduction in virus shedding.
The Impact of Vaccination on COVID-19 Burden of Disease in the Adult and Elderly Population: A Systematic Review of Italian Evidence
Authors: Calabrò Giovanna Elisa , Pappalardo Ciro , D’Ambrosio Floriana , Vece Michele , Lupi Chiara , Lontano Alberto , Di Russo Mattia , Ricciardi Roberto , de Waure Chiara
Published: May 2023

COVID-19 is a major global health threat, with millions of confirmed cases and deaths worldwide. Containment and mitigation strategies, including vaccination, have been implemented to reduce transmission and protect the population. We conducted two systematic reviews to collect nonrandomized studies investigating the effects of vaccination on COVID-19-related complications and deaths in the Italian population. We considered studies conducted in Italian settings and written in English that contained data on the effects of vaccination on COVID-19-related mortality and complications. We excluded studies that pertained to the pediatric population. In total, we included 10 unique studies in our two systematic reviews. The results showed that fully vaccinated individuals had a lower risk of death, severe symptoms, and hospitalization compared to unvaccinated individuals. The review also looked at the impact of vaccination on post-COVID-19 syndrome, the effectiveness of booster doses in older individuals, and nationwide adverse events. Our work highlights the crucial role that vaccination campaigns have played in reducing the burden of COVID-19 disease in the Italian adult population, positively impacting the pandemic trajectory in Italy.
Vaccines against Tuberculosis: Where Are We Now?
Authors: Srivastava Shruti , Dey Sajal , Mukhopadhyay Sangita
Published: May 2023

Tuberculosis (TB) is among the top 10 leading causes of death in low-income countries. Statistically, TB kills more than 30,000 people each week and leads to more deaths than any other infectious disease, such as acquired immunodeficiency syndrome (AIDS) and malaria. TB treatment is largely dependent on BCG vaccination and impacted by the inefficacy of drugs, absence of advanced vaccines, misdiagnosis improper treatment, and social stigma. The BCG vaccine provides partial effectiveness in demographically distinct populations and the prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB incidences demands the design of novel TB vaccines. Various strategies have been employed to design vaccines against TB, such as: (a) The protein subunit vaccine; (b) The viral vector vaccine; (c) The inactivation of whole-cell vaccine, using related mycobacteria, (d) Recombinant BCG (rBCG) expressing Mycobacterium tuberculosis (M.tb) protein or some non-essential gene deleted BCG. There are, approximately, 19 vaccine candidates in different phases of clinical trials. In this article, we review the development of TB vaccines, their status and potential in the treatment of TB. Heterologous immune responses generated by advanced vaccines will contribute to long-lasting immunity and might protect us from both drug-sensitive and drug-resistant TB. Therefore, advanced vaccine candidates need to be identified and developed to boost the human immune system against TB.
Antimicrobial Use in Canadian Cow–Calf Herds
Authors: Fossen Jayce D. , Campbell John R. , Gow Sheryl P. , Erickson Nathan , Waldner Cheryl L.
Published: May 2023

Despite growing concern surrounding antimicrobial use (AMU) and the importance of cow–calf herds to the Canadian livestock industry, surveillance of AMU in cow–calf herds to inform antimicrobial stewardship programs has been sporadic. Producers from the Canadian Cow–Calf Surveillance Network (87%, 146/168) provided data and almost all reported AMU in at least one animal (99%, 145/146 herds) in 2019–2020. The most common reasons for AMU were treatment of respiratory disease in nursing calves in 78% of herds and neonatal diarrhea in 67% of herds, as well as for lameness in cows in 83% of herds. However, most herds treated <5% of animals for these reasons. Less than 2.5% of herds treated more than 30% of calves for either bovine respiratory disease or neonatal diarrhea and no herds treated more than 30% of cows for lameness. The most frequently reported antimicrobial was oxytetracycline in 81% of herds, followed by florfenicol in 73% of herds. Antimicrobials with very high importance to human health, such as ceftiofur, were used at least once by 20% of herds but were only used in >30% of nursing calves from one herd. Similarly, while 56% of herds used macrolides at least once, within-herd use was the highest in nursing calves where <4% of herds reported use in >30% of animals. Herds using artificial insemination and calving in the winter were more likely (p = 0.05) to treat >5% of nursing calves for respiratory disease, suggesting the importance of vaccination programs for herds at risk. Overall, AMU was similar to previous Canadian studies; however, the percentage of herds using macrolides had increased from a comparable study in 2014.
Improving Wheat Grain Yield and Nitrogen Use Efficiency by Optimizing the Fertigation Frequency Using Center Pivot Irrigation System
Authors: Cai Dongyu , Shoukat Muhammad Rizwan , Zheng Yudong , Tan Haibin , Sun Mengyao , Yan Haijun
Published: May 2023

High efficient nitrogen (N) application method and proper N management strategies can further reduce the losses and enhance N use efficiency. Field experiments were conducted in the 2015–2016 and 2016–2017 growing seasons to evaluate the effects of four fertigation frequencies treatments (FT-1: all the topdressing N was applied at the jointing stage; FT-2: 67% and 33% of the topdressing N was applied at the jointing and filling stages; FT-3: 33%, 50% and 17% of the topdressing N was applied at the regreening, jointing and filling stages; FT-4: 33%, 33%, 17% and 17% of the topdressing N were applied at the regreening, jointing, anthesis and filling stages) on wheat yield, water use efficiency (WUE), partial productivity of N fertilizer (PFPN) and N harvest index (NHI). In addition, one-time topdressing by surface broadcasting at the jointing stage was set up as a control (BC-1). The results showed that FT-3 and FT-4 supplied sufficient NO3−-N in the 0–40 cm soil layer, which reduced the risk of soil NO3−-N leaching to the deeper layers. FT-4 had the highest grain yield, WUE, PFPN and NHI, with average values of 9153.4 kg ha−1, 2.1 kg m−3, 0.74 kg kg−1 and 31.3 kg kg−1, respectively, followed by these values corresponding to the FT-3 in two years. These findings suggest that topdressing N split with 3–4 times, that is to say applying approximately 16.7% of topdressing N in anthesis and filling stages, respectively by the center pivot fertigation method can significantly improve yield, WUE, PFPN and NHI.
Evolution of Drought Trends under Climate Change Scenarios in Karst Basin
Authors: Mo Chongxun , Tang Peiyu , Huang Keke , Lei Xingbi , Lai Shufeng , Deng Juan , Bao Mengxiang , Sun Guikai , Xing Zhenxiang
Published: May 2023

Karst basins have a relatively low capacity for water retention, rendering them very vulnerable to drought hazards. However, karst geo-climatic features are highly spatially heterogeneous, making reliable drought assessment challenging. To account for geo-climatic heterogeneous features and to enhance the reliability of drought assessment, a framework methodology is proposed. Firstly, based on the history of climate (1963–2019) from the Global Climate Model (GCM) and station observations within the Chengbi River karst basin, a multi-station calibration-based automated statistical downscaling (ASD) model is developed, and the Kling–Gupta efficiency (KGE) and Nash–Sutcliffe efficiency (NSE) are selected as performance metrics. After that, future climate (2023–2100) under three GCM scenarios (SSP1-2.6, SSP2-4.5, and SSP5-8.5) are obtained by using the ASD model. Finally, the Standardized Precipitation Evapotranspiration Index (SPEI), calculated by future climate is applied to assess drought conditions. The results indicate that the multi-station calibration-based ASD model has good performance and thus can be used for climate data downscaling in karst areas. Precipitation mainly shows a significant upward trend under all scenarios with the maximum variation (128.22%), while the temperature shows a slow upward trend with the maximum variation (3.44%). The drought condition in the 2040s is still relatively severe. In the 2060s and 2080s, the basin is wetter compared with the historical period. The percentage of drought duration decreases in most areas from the 2040s to the 2080s, demonstrating that the future drought condition is alleviated. From the SSP1-2.6 scenario to the SSP5-8.5 scenario, the trend of drought may also increase.
Recognition of the Interaction Mechanisms between Water and Land Resources Based on an Improved Distributed Hydrological Model
Authors: Wang Jianwei , Lv Xizhi , Qin Tianling , Ni Yongxin , Ma Li , Zhang Qiufen , Nie Hanjiang , Lv Zhenyu , Li Chenhao , Zhang Xin , Feng Jianming
Published: May 2023

Conflicts between humans and land use in the process of using water and conflicts between humans and water resources in the process of using land have led to an imbalance between natural ecosystems and socio-economic systems. It is difficult to understand the impact of the processes of water production and consumption on land patches and their ecological effects. A grid-type, basin-distributed hydrological model was established in this study, which was based on land-use units and coupled with groundwater modules to simulate the water production and consumption processes in different units. By combining land use and net primary productivity, the runoff coefficient and the water use efficiency (NPP/ET) of different land units were used as indicators to characterize the interaction between water and land resources. The results showed that the average runoff coefficients of cultivated land, forest land and grassland were 0.7, 0.5 and 0.9, respectively. Moreover, the average runoff coefficients of hills, plains and basins were 0.7, 0.7 and 0.8, respectively. The NPP produced by the average unit, evapotranspiration, in cultivated land, forest land and grassland was 7 (gC/(m2•a))/mm, 0.7 (gC/(m2•a))/mm and 0.2 (gC/(m2•a))/mm, respectively. These results provide quantitative scientific and technological support in favor of the comprehensive ecological management of river basins.
Coordinated Control Strategy for Drive Mode Switching of Double Rotor In-Wheel Motor Based on MPC and Control Allocation
Authors: Li Junmin , Wang Junchang , Liu Jianhao , Ren Chongyang
Published: May 2023

To overcome the problems existing in the practical application of traditional in-wheel motors used for electric vehicles, an integrated double rotor in-wheel motor was proposed, which can realize three drive modes to meet variable operating condition requirements of the vehicle. The process of switching between different drive modes affects the ride comfort of a vehicle. Taking the mode switching from a single inner motor drive to a dual-motor coupling drive as a research object, a dynamic modeling method of drive mode switching based on the switching system was proposed. According to the critical conditions of each state transition, the switching rules expressed by the segmental constant function were designed. At the engagement stage of electromagnetic clutch II, the torque coordination control strategy based on model predictive control (MPC) and control allocation was proposed. The simulation results show that the proposed strategy can effectively reduce the impact degree of a vehicle and the slipping-friction work of the clutch on the premise of ensuring the fast response of mode switching and the steady increase in vehicle speed. The switching quality of the mode-switching process is effectively improved. In addition, the drive mode switching control of the double rotor in-wheel motor prototype was tested, which proves its ability to operate in multi-drive mode.
Identification of frailty in primary care: accuracy of electronically derived measures
Authors: Swart Karin MA , van der Heijden Amber AWA , Blom Marieke T , Overbeek Jetty A , Nijpels Giel , van Hout Hein PJ , Elders Petra JM , Herings Ron MC
Published: May 2023

Background

Routinely collected clinical data based on electronic medical records could be used to define frailty.

Aim

To estimate the ability of four potential frailty measures that use electronic medical record data to identify older patients who were frail according to their GP.

Design and setting

This retrospective cohort study used data from 36 GP practices in the Dutch PHARMO Data Network.

Method

The measures were the Dutch Polypharmacy Index, Charlson Comorbidity Index (CCI), Chronic Disease Score (CDS), and Frailty Index. GPs’ clinical judgement of patients’ frailty status was considered the reference standard. Performance of the measures was assessed with the area under the receiver operating characteristic curve (AUC). Analyses were done in the total population and stratified by age and sex.

Results

Of 31 511 patients aged ≥65 years, 3735 (11.9%) patients were classified as frail by their GP. The CCI showed the highest AUC (0.79, 95% confidence interval [CI] = 0.78 to 0.80), followed by the CDS (0.69, 95% CI = 0.68 to 0.70). Overall, the measures showed poorer performance in males and females aged ≥85 years than younger age groups (AUC 0.55–0.58 in females and 0.57–0.60 in males).

Conclusion

This study showed that of four frailty measures based on electronic medical records in primary care only the CCI had an acceptable performance to assess frailty compared with frailty assessments done by professionals. In the youngest age groups diagnostic performance was acceptable for all measures. However, performance declined with older age and was least accurate in the oldest age group, thereby limiting the use in patients of most interest.
Factors associated with the consultation of GPs among adults aged ≥16 years: an analysis of data from the Health Survey for England 2019
Authors: Song Fujian , Bachmann Max , Howe Amanda
Published: May 2023

Background

Understanding the factors associated with demands for general practice care is crucial for policy decision makers to appropriately allocate healthcare resources.

Aim

To investigate factors associated with the frequency of GP consultations.

Design & setting

Data on 8086 adults aged ≥16 years was obtained from cross-sectional Health Survey for England (HSE) 2019.

Method

The primary outcome was the frequency of consultations of a GP in the last 12 months. Multivariable ordered logistic regression analysis was used to evaluate associations between GP consultations and a range of sociodemographic and health-related factors.

Results

Frequency of GP consultations for all reasons was higher among females (odds ratio [OR] 1.81, 95% confidence interval [CI] = 1.64 to 2.01), those aged ≥75 years (OR 1.48, 95% CI = 1.15 to 1.92), ethnic minority populations (Black: OR 1.42, 95% CI = 1.09 to 1.84; Asian: OR 1.53, 95% CI = 1.25 to 1.87), lowest household income (OR 1.53, 95% CI = 1.29 to 1.83), adults with long-lasting illnesses (OR 3.78, 95% CI = 3.38 to 4.22), former smokers (OR 1.17, 95% CI = 1.04 to 1.22), being overweight (OR 1.14, 95% CI = 1.01 to 1.29), and being obese (OR 1.32, 95% CI = 1.16 to 1.50). Predictors of consultations for physical health problems were similar to predictors of consultations for any health problems. However, younger age was associated with more consultations for mental health problems, or a combination of mental and physical health problems.

Conclusion

The higher frequency of consultation of GPs is associated with female sex, older age, ethnic minority populations, being socioeconomically disadvantaged, existence of lasting illnesses, smoking, being overweight, and being obese. Older age is associated with increased consultations for physical health problems, but associated with reduced consultations for mental health or a combination of mental and physical health problems.