bluuebunny/crossref_metadata_2025 huggingface dataset:
PROTACs: A Hope for Breast Cancer Patients?
Authors: Kaur Rajwinder , Chaudhary Gaurav , Kaur Amritpal , Singh Pargat , Longowal Gagan Deep , Sapkale Gayatri P. , Arora Sandeep
Published: March 2021

Background:

Breast Cancer (BC) is the most widely recognized disease in women. A massive number of women are diagnosed with breast cancer and many lost their lives every year. Cancer is the subsequent driving reason for dying, giving rise to it one of the current medication's most prominent difficulties.

Objectives:

The main objective of the study is to examine and explore novel therapy (PROTAC) and its effectiveness against breast cancer.

Methods:

The literature search was done across Medline, Cochrane, ScienceDirect, Wiley Online, Google Scholar, PubMed, Bentham Sciences from 2001 to 2020. The articles were collected; screened, segregated, and selected papers were included for writing the review article.

Results and Conclusion:

A novel innovation emerged around two decades ago that has great potential to not only overcome the limitations but also can provide future direction for the treatment of many diseases which has presently not many therapeutic options available and regarded as incurable with traditional techniques; that innovation is called PROTAC (Proteolysis Targeting Chimera) and able to efficaciously ubiquitinate and debase cancer encouraging proteins by noncovalent interaction. PROTACs are constituted of two active regions isolated by a linker and equipped for eliminating explicit undesirable protein. It is empowering greater sensitivity to "drug-resistant targets" as well as a more prominent opportunity to influence non-enzymatic function. PROTACs have been demonstrated to show better target selectivity contrasted with traditional small-molecule inhibitors. So far, the most investigation into PROTACs possesses particularly concentrated on applications to cancer treatment including breast cancer, the treatment of different ailments may profit from this blossoming innovation.
Green Synthesis of 1H-pyrazolo[1,2-b]phthalazinedione-2-carbonitriles in the Presence of L-proline
Authors: Habibi Davood , Shojaei Saeedeh , Heydari Somayyeh
Published: March 2021

Background:

Pyrazolophthalazinedione derivatives show various biological activities
such as anti-bacterial, anti-cancer, anti-coagulant, anti-convulsant, anti-fungal, anti-hypoglycemic,
anti-inflammatory, anti-tumor, anti-viral, cardiotonic, cytotoxic and vasorelaxant activities.

Objective:

The purpose of this study was to synthesize compounds that have various medicinal
properties.

Methods:

Diverse 3-amino-5,10-dioxo-1-phenyl-5,10-dihydro-1H-pyrazolo[1,2-b]phthal-azine-2--
carbonitriles were synthesized from the one-pot three components green synthesis of phthalhydrazides,
aromatic aldehydes and malononitrile in the presence of the proline organocatalyst in
ethanol at reflux conditions in excellent yields.

Results:

Proline was used as an efficient organocatalyst for the one-pot three components green
synthesis of diverse pyrazolophthalazinecarbonitriles. In the absence of the proline organocatalyst,
the yield was very low. Also, electron withdrawing or electron releasing groups don’t have a meaningful
effect on the reaction times and the structures of all products were in agreement with their
IR and NMR spectra.

Conclusion:

In the IR spectra, the appearance of the sharp NH2 and the CN peaks at about 3300
and 2300 cm-1, respectively confirm formation of the products.
Analyzing the Essential Attributes of Nationally Issued COVID-19 Contact Tracing Apps: Open-Source Intelligence Approach and Content Analysis
Authors: Weiß Jan-Patrick , Esdar Moritz , Hübner Ursula
Published: March 2021

Background

Contact tracing apps are potentially useful tools for supporting national COVID-19 containment strategies. Various national apps with different technical design features have been commissioned and issued by governments worldwide.

Objective

Our goal was to develop and propose an item set that was suitable for describing and monitoring nationally issued COVID-19 contact tracing apps. This item set could provide a framework for describing the key technical features of such apps and monitoring their use based on widely available information.

Methods

We used an open-source intelligence approach (OSINT) to access a multitude of publicly available sources and collect data and information regarding the development and use of contact tracing apps in different countries over several months (from June 2020 to January 2021). The collected documents were then iteratively analyzed via content analysis methods. During this process, an initial set of subject areas were refined into categories for evaluation (ie, coherent topics), which were then examined for individual features. These features were paraphrased as items in the form of questions and applied to information materials from a sample of countries (ie, Brazil, China, Finland, France, Germany, Italy, Singapore, South Korea, Spain, and the United Kingdom [England and Wales]). This sample was purposefully selected; our intention was to include the apps of different countries from around the world and to propose a valid item set that can be relatively easily applied by using an OSINT approach.

Results

Our OSINT approach and subsequent analysis of the collected documents resulted in the definition of the following five main categories and associated subcategories: (1) background information (open-source code, public information, and collaborators); (2) purpose and workflow (secondary data use and warning process design); (3) technical information (protocol, tracing technology, exposure notification system, and interoperability); (4) privacy protection (the entity of trust and anonymity); and (5) availability and use (release date and the number of downloads). Based on this structure, a set of items that constituted the evaluation framework were specified. The application of these items to the 10 selected countries revealed differences, especially with regard to the centralization of the entity of trust and the overall transparency of the apps’ technical makeup.

Conclusions

We provide a set of criteria for monitoring and evaluating COVID-19 tracing apps that can be easily applied to publicly issued information. The application of these criteria might help governments to identify design features that promote the successful, widespread adoption of COVID-19 tracing apps among target populations and across national boundaries.
Natural Language Processing of Clinical Notes to Identify Mental Illness and Substance Use Among People Living with HIV: Retrospective Cohort Study (Preprint)
Authors: Ridgway Jessica P , Uvin Arno , Schmitt Jessica , Oliwa Tomasz , Almirol Ellen , Devlin Samantha , Schneider John
Published: March 2021

BACKGROUND

Mental illness and substance use are prevalent among people living with HIV and often lead to poor health outcomes. Electronic medical record (EMR) data are increasingly being utilized for HIV-related clinical research and care, but mental illness and substance use are often underdocumented in structured EMR fields. Natural language processing (NLP) of unstructured text of clinical notes in the EMR may more accurately identify mental illness and substance use among people living with HIV than structured EMR fields alone.

OBJECTIVE

The aim of this study was to utilize NLP of clinical notes to detect mental illness and substance use among people living with HIV and to determine how often these factors are documented in structured EMR fields.

METHODS

We collected both structured EMR data (diagnosis codes, social history, Problem List) as well as the unstructured text of clinical HIV care notes for adults living with HIV. We developed NLP algorithms to identify words and phrases associated with mental illness and substance use in the clinical notes. The algorithms were validated based on chart review. We compared numbers of patients with documentation of mental illness or substance use identified by structured EMR fields with those identified by the NLP algorithms.

RESULTS

The NLP algorithm for detecting mental illness had a positive predictive value (PPV) of 98% and a negative predictive value (NPV) of 98%. The NLP algorithm for detecting substance use had a PPV of 92% and an NPV of 98%. The NLP algorithm for mental illness identified 54.0% (420/778) of patients as having documentation of mental illness in the text of clinical notes. Among the patients with mental illness detected by NLP, 58.6% (246/420) had documentation of mental illness in at least one structured EMR field. Sixty-three patients had documentation of mental illness in structured EMR fields that was not detected by NLP of clinical notes. The NLP algorithm for substance use detected substance use in the text of clinical notes in 18.1% (141/778) of patients. Among patients with substance use detected by NLP, 73.8% (104/141) had documentation of substance use in at least one structured EMR field. Seventy-six patients had documentation of substance use in structured EMR fields that was not detected by NLP of clinical notes.

CONCLUSIONS

Among patients in an urban HIV care clinic, NLP of clinical notes identified high rates of mental illness and substance use that were often not documented in structured EMR fields. This finding has important implications for epidemiologic research and clinical care for people living with HIV.
Relaciones sociales y académicas en estudiantes de Diseño a través de la plataforma “Second Life”
Authors: Uribe Santiago , Dillon Francisco
Published: March 2021

El objetivo de este trabajo fue determinar si el entorno virtual de aprendizaje “Second Life” mejora las relaciones sociales y académicas de la materia de Diseño Básico Bidimensional de la carrera de Diseño Gráfico. El enfoque de la investigación fue de tipo cuantitativo pre experimental, de tipo secuencial exploratorio. La muestra del estudio correspondió a 12 estudiantes (8 hombres y 4 mujeres) de primer semestre de la carrera de Diseño Gráfico, en la Universidad Tecnológica Indoamérica, modalidad presencial de la ciudad de Quito, Ecuador. El trabajo concluye que, la utilización de la plataforma “Second Life” como entorno virtual y estrategia didáctica de aprendizaje mejora las relaciones sociales y el rendimiento académico en la materia de Diseño Básico Bidimensional de la población en estudio.
Identidades docentes en Paraguay: investigación educativa basada en artes
Authors: Huerta Ricard
Published: March 2021

En este trabajo presentamos los resultados del proyecto Mujeres Maestras, un proyecto de investigación internacional con quince años de trayectoria, que busca, mediante las artes, elaborar un discurso visual que se convierte en homenaje al colectivo de las maestras. Tras presentar las características de esta investigación basada en las artes y la trayectoria del proyecto a nivel internacional, nos centramos en el caso concreto de la experiencia del Paraguay. En Mujeres Maestras del Paraguay se presenta la creación artística como herramienta de construcción de narrativas personales y colectivas. El trabajo muestra una selección de piezas artísticas del proyecto, así como algunos relatos de las propias maestras.
Actitudes de los maestros ante la inclusión educativa en Colombia, Guatemala y España
Authors: Hernández Izquierdo Laura , Marchesi Álvaro
Published: March 2021

Los maestros son un elemento clave en el desarrollo de la educación inclusiva y sus actitudes, a su vez, repercuten de manera directa en las actitudes de sus propios alumnos. Por ello, es fundamental conocer la opinión del profesorado hacia la diversidad y la permanencia de diferentes alumnos en sus aulas. Para este estudio se contó con la colaboración de 132 maestros y 40 especialistas en educación de Guatemala, Colombia y España, a los que se les aplicó un cuestionario individual además de entrevistas abiertas. Profesores de tres países con diferente desarrollo social, cultural y educativo transmitieron sus impresiones sobre la inclusión de alumnos con discapacidad y la inclusión de alumnos de otras culturas. Entre otros, los resultados muestran como en las tres naciones no existen las condiciones adecuadas para conseguir una inclusión plena de los alumnos con necesidades educativas especiales en la escuela ordinaria. Por otro lado, se identifican barreras actitudinales y de discriminación hacia la población indígena y afrodescendiente en Guatemala y Colombia, respectivamente, que son transmitidas a los más pequeños desde su contexto educativo, familiar y social.
The humanitarian aspect of the strategic partnership between Vietnam and Russia
Authors: Ponka Tatyana I. , Yuniushkina Anna S. , Dubrovsky Ivan R.
Published: March 2021

The Article is devoted to the humanitarian cooperation between Russia and Vietnam in 1991-2019. Currently, Russia and Vietnam are united by the desire to structure the regional subsystem through joint participation in economic integration and strengthening the security system in the Asia-Pacific region. In this regard, the question of how Russia and Vietnam build bilateral relations, characterized as a comprehensive strategic partnership, is becoming more and more relevant. The most interesting is the humanitarian aspect of relations, since in the modern realities of globalization, in addition to the military and economic aspects of bilateral interaction between States that claim a significant role in the system of international relations, it is humanitarian imperatives that acquire special significance. By promoting their national culture in the partner country and developing bilateral ties in the fields of education, science, information, sports and tourism, the countries strengthen their bilateral relations, which allows them to coordinate their actions more confidently and realize their national interests at the global and regional levels. The purpose of the article is to identify trends in Russian-Vietnamese humanitarian relations in 1991-2019. To achieve this goal, an analysis of the legal framework of humanitarian relations between Russia and Vietnam was conducted, as well as the content of humanitarian relations between the two countries in the field of education, culture and humanitarian contacts. The authors considered the significance of the studied segment of bilateral relations in the national political and expert-analytical discourses of Russia and Vietnam. The article notes the existence of historical and organizational potential necessary for implementation in the Russian-Vietnamese humanitarian dialogue. The authors conclude that the humanitarian aspect plays an important role, since it is an integral part of bilateral relations and a promising component of the implementation of national interests.
Funeral Epitaph of Zhao Rugua (1170-1231), the Author of Zhufan zhi (“Records of Foreign Peoples”; 1225). Structural-Descriptive and Archaelogical Analysis of the Source
Authors: Zaitsev Ivan Alexeevich , Kolnin Ilia Sergeevich
Published: March 2021

The present work is a continuation of two previously published articles in which the biography of Zhao Rugua 趙汝适 (1170-1231), the author of Zhufan zhi 諸蕃志 (Records of Foreign Peoples; 1225) an important historical geographical source about the foreign lands during the Song dynasty (960-1279), was studied through the usage of the text of his funeral epitaph as well as other historical sources. They also included the translation of the text of inscription into Russian and English [1; 2]. The goal of this article is to deepen the study of Zhao Ruguas funeral epitaph by researching the material features of the source, analyzing the structure of the text and comparing it with other similar sources of Medieval China. In contrast with the previous works the inscription in this article is analyzed both as a textual source and as an object of material culture which enables to understand the context of the creation of the source as well as the extent of detalization of the deceaseds biography.
“Transformative agency” as an object of sociological analysis: Contemporary discussions and the role of education
Authors: Sorokin P. S.
Published: March 2021

Negative trends of the global social-economic development enhanced by the covid-19 pandemic explain the theoretical and practical relevance of the study of perspectives for structural transformations and their possible sources. In education, this means the need to improve the existing models of institutional practice and to contribute to the development of agency that would support positive transformations in all domains of social life. The scientific attention to agency and its transformative potential in relation to structures is still limited compared to the issues of structures reproduction. The so-called new institutionalists in sociology (including primarily J.W. Meyer and his followers) provide a promising basis for new theoretical models and empirical studies of the content, factors and effects of transformative agency. Meyers core idea is that social structures can both suppress and support the initiative formation of new social entities and the corresponding new values and modes of action. Further research in education should refer to the concepts of institutional entrepreneurship, institutional work and expanded actorhood, when using the proposed theoretical framework to empirically study (1) globally and nationally promoted initiatives in entrepreneurship education in universities, and (2) processes of transformation of institutional contexts in education under the continuing global pandemic with an emphasis on the proactive role of students.
Emblematics and a Cure for Melancholy in Robert Burton’s The Anatomy of Melancholy
Authors: Zelenin Daniil A.
Published: March 2021

The article analyzes emblematic discourse in Robert Burton’s The Anatomy of Melancholy, offering an extended view of the emblematics that organizes both the structure and the narrative of the book and is anticipated by the emblematic frontispiece. The article examines the book’s intricate structure in its connection with the generic uncertainty of the text. The singular vs universal dualism forms the book’s underpinning structure that implies emblematic and dialectic intentions of The Anatomy of Melancholy. The article further analyzes the emblematic frontispiece, revealing consistently explicated emblematic structures that emphasize the antithesis of “duplicity” vs “singularity” implicit in the book’s multi-level structure. Analysis further demonstrates the book’s continuity with cento- and florilegia traditions, also epitomized in the emblematic method. The essay argues that Burton was using discursive emblems and the emblematic discourse to establish his status as an artifex, which helps him avoid melancholy himself and encourage his reader to struggle with it. The article postulates that the emblematic frontispiece embodies the dialectic of “duplicity” and “singularity” and solves it by enabling the emblematic mechanism of reading of the book through the emblematic lenses, uniting the Word and the Image: it is what Burton eventually offers both himself and his reader to cure melancholy.
Limites e possibilidades do atendimento educacional especializado numa escola de tempo integral
Authors: Sala Marcos Elias , Moreno Kênia Santos , Duarte Amanda Aparecida Pereira
Published: March 2021

O presente trabalho apresenta uma discussão a respeito da organização do AEE (Atendimento Educacional Especializado) num colégio de aplicação organizado em tempo integral, percebendo-se diversas potencialidades e limitações, que precisam ser discutidas e amadurecidas entre toda a comunidade escolar. Paralelamente, é preciso produzir conhecimento para munir o Poder Legislativo de elementos que possam contribuir na proposição de leis que favoreçam os estudantes PAEE (Público-Alvo da Educação Especial) de fato, especialmente quando se trata de crianças com necessidades especiais, que ficam durante boa parte do dia no ambiente escolar. A metodologia adotada foi a observação participante, na qual os atores/autores estão envolvidos diretamente na problemática apresentada. À guisa de conclusão, considera-se que o país inteiro ainda está num processo inicial de discussão para construção, implementação e consolidação do AEE nas escolas, apesar da relativa antiguidade da obrigatoriedade legal da oferta dessa modalidade educacional.
Projeto acrobatas: processo de criação de uma apresentação coreográfica
Authors: Marmitt Alícia , Cafruni Cristina Borges
Published: March 2021

O Projeto Acrobatas é uma ação de extensão desenvolvida no Colégio de Aplicação que oferece a prática da Ginástica Para Todos para os alunos do colégio e da comunidade. Este relato teve como objetivo descrever o processo de criação de uma apresentação coreográfica do Projeto Acrobatas. As aulas ocorreram em um encontro por semana, com turmas divididas em duas faixas etárias, de 7 a 10 anos e de 11 a 13 anos. Para o processo de criação coreográfica, foram realizadas atividades como o laboratório temático de movimentos, que envolveu a participação e a interação dos alunos. A escolha do tema da coreografia ocorreu com base na observação do interesse dos alunos.   Concluiu-se que a Ginástica Para Todos promoveu um incremento para além do desenvolvimento motor dos alunos, pois possibilitou trabalhos multi/interdisciplinares. Através do processo de criação coreográfica foram desenvolvidas diversas competências, entre elas, a cooperação e a criatividade.
Educação ambiental: refletindo sobre a relação criança e natureza na educação infantil
Authors: Spinelli Carolina Shimomura , Zucco Jucilaine , Euzébio Juliana Da Silva
Published: March 2021

Este texto apresenta o “Projeto de extensão: Educação Ambiental - refletindo sobre a relação criança e natureza na Educação Infantil” do Núcleo de Desenvolvimento Infantil (NDI) da Universidade Federal de Santa Catarina (UFSC). Este projeto de extensão vem há mais de 10 anos realizando diversas ações voltadas para a relação da criança com a natureza. Possui uma perspectiva histórico-cultural que tem como fundamento a compreensão de que o homem ao transformar a natureza a fim de atender às suas necessidades transforma a si próprio, se humaniza. O projeto almeja a ampliação dos conhecimentos das crianças, de professores e de técnicos do NDI. E se constitui como campo de pesquisa, atuando sobre a formação profissional de acadêmicos, bem como sobre a formação da comunidade externa e de profissionais de outras instituições. Deste modo, articulando as ações de ensino, pesquisa e extensão.
Laboratório de Ensino e Pesquisa em Ciências Sociais (LEPCS): articulando ensino e extensão, da educação básica à licenciatura, em um colégio de aplicação
Authors: Souza Guilherme Nogueira de , Pain Rodrigo De Souza
Published: March 2021

O presente trabalho pretende analisar a estrutura e o funcionamento do Laboratório de Ensino e Pesquisa em Ciências Sociais (LEPCS), um projeto de extensão desenvolvido no Instituto de Aplicação Fernando Rodrigues da Silveira (CAp) da Universidade do Estado do Rio de Janeiro (UERJ). Vinculado ao Departamento de Ciências Humanas e Filosofia (DCHF/CAp/UERJ), o laboratório constitui-se de um coletivo voltado à formação curricular e extracurricular de estudantes de licenciatura em Ciências Sociais, além de contribuir para formação continuada de professores de Sociologia inseridos na educação básica. Com ações, distintas, porém integradas, o LEPCS tem contribuído para a formação de estudantes e futuros professores, colocando-se como ponto de contato entre a universidade e a educação básica.
A charge como fonte histórica e ferramenta didática no ensino de História
Authors: Romero Marcelo
Published: March 2021

Essa pesquisa objetiva desenvolver entre os alunos da educação básica os procedimentos característicos da investigação de documentos imagéticos por meio da realização de atividades voltadas para a constituição de uma análise histórica da charge, como a produção de fichas técnicas de análise e de inventários temáticos. Pretende, assim, contribuir para a compreensão de que a investigação histórica se realiza em meio à multiplicidade de procedimentos metodológicos e fontes históricas existentes e/ou disponíveis, além de fomentar o processo de construção do conceito de tempo histórico por meio da prática de identificação das diferentes temporalidades existentes em um dado contexto. Os resultados até aqui obtidos originaram um banco de dados com o material produzido pelos estudantes, cuja análise será objeto de outra publicação, além da produção de material didático sobre os conteúdos selecionados para o desenvolvimento da pesquisa até o momento.
Calidad fisicoquímica y microbiológica del agua superficial del río Grande de Tárcoles, Costa Rica: un enfoque ecológico​
Authors: Pérez Gómez Gabriela , Alvarado García Virginia , Rodríguez Rodríguez Jorengeth Abad , Herrera Federico , Sánchez Gutiérrez Rolando
Published: March 2021

Introducción: La calidad del agua en una cuenca hidrográfica, y su uso potencial, se ven afectados por factores antrópicos y naturales. El río Tárcoles es el receptor final de aguas de la región central de Costa Rica, donde el tratamiento de aguas residuales es inadecuado o inexistente. Objetivo: Evaluar la contaminación del agua en el río y evaluar a los macroinvertebrados como bioindicadores del ecosistema. Métodos: Se realizaron evaluaciones fisicoquímicas, microbiológicas y de macroinvertebrados del agua superficial en cuatro sitios durante doce meses consecutivos, incluidos dos índices de calidad del agua (ICA-NSF y holandés). Hicimos visitas mensuales para la colocación y recolección de sustratos artificiales para macroinvertebrados acuáticos, y visitas bimensuales para la recolección de muestras de agua para análisis ex situ de los parámetros fisicoquímicos y microbiológicos. Además, se caracterizó el uso del suelo en la parte baja de Tárcoles a partir de archivos tipo “raster” de cobertura. Resultados: Algunas variables fisicoquímicas tuvieron concentraciones similares a las informadas para otros ríos costarricenses, mientras que el oxígeno fue inferior. Las variables microbiológicas indicaron altos niveles de contaminación, especialmente en la época de lluvias. En la estación seca, hubo más macroinvertebrados acuáticos, siendo Chironomidae, Oligochaeta e Hydrobiidae los más abundantes. La contaminación de los ríos se clasifica como "incipiente" según el índice holandés y como "calidad media" según el ICA-NSF. Conclusiones: la contaminación del río Tárcoles se debe principalmente a un uso inadecuado del suelo y actividades antrópicas. Recomendamos un plan de gestión de cuencas e investigación sobre la salud del ecosistema y la conservación de especies vulnerables.
Impacto del aislamiento social en MiPymes del calzado en Colombia ocasionado por choque exógeno (SARS CoV-2)
Authors: Medina Rojas Iván Darío , Sánchez Parra Eliana Patricia , Solís Montaño Yedy Alejandra
Published: March 2021

Introducción: se propende por realizar una aproximación al choque exógeno ocasionado por el SARS CoV-2 y su afectación en las MiPymes del calzado en Colombia, tomando una radiografía una vez se determinan medidas de distanciamiento social.  Las empresas se ven afectadas negativamente por la cuarentena y el impacto generado por la incertidumbre toma parte en las decisiones, reduciendo la capacidad de predecir resultados con precisión. Metodología: de manera descriptiva, utilizando un cuestionario semiestructurado y mediante vía telefónica, se establece contacto con 34 MiPymes del calzado (ubicadas en las ciudades de Bogotá, Cali y Cúcuta); se indagan aspectos relacionados con la operación y gestión en medidas de confinamiento, de igual manera, sobre propuestas de avance. Resultados: más de tres cuartas partes de las empresas no han podido operar de la misma forma una vez se fijó el decreto de cuarentena, el rendimiento en producción y ventas sufrió un marcado decrecimiento, mermando el flujo de efectivo y reduciendo la capacidad de maniobra de las empresas.  Las MiPymes del sector tienen un escenario muy complejo por lo que es importante determinar estrategias que permitan llevar la situación. Resultados: dado que el impacto en el sector ha sido marcado por pérdidas considerables, las estrategias basadas en modelos colaborativos, de trabajo en red, con articulación entre partes interesadas (sector público, privado y agremiaciones) resultan necesarias para reducir el grado de afectación; sumado a ello, el apoyo en las nuevas tecnologías como el marketing digital, o en la creación de una tienda multimarca, posiblemente permitirá revertir el fenómeno adverso.
A computational study of the interface interaction between SARS-CoV-2 RBD and ACE2 from human, cat, dog and ferret.
Authors: Sote William , Franca Eduardo , Hora Aline , Comar Moacyr
Published: March 2021

The total impact of the worldwide COVID-19 pandemic is still emerging,
changing all relationships as a result, including those with pet
animals. In the infection process, the use of Angiotensin-converting
enzyme 2 (ACE2) as a cellular receptor to the spike protein of the new
coronavirus is a fundamental step. In this sense, understanding which
residue plays what role in the interaction between SARS-CoV-2 spike
glycoprotein and ACE2 from cats, dogs, and ferrets is an important guide
for helping to choose which animal model can be used to study the
pathology of COVID-19 and if there are differences between these
interactions and those occurring in the human system. Hence, trying to
help to answer these questions, we performed classical molecular
dynamics simulations to evaluate, from an atomistic point of view, the
interactions in these systems. Our results show that there are
significant differences in the interacting residues between the systems
from different animal species, and the role of ACE2 key residues are
different in each system and can assist in the search for different
inhibitors for each animal.
Bilateral Posterior Canal Benign Paroxysmal Positional Vertigo Co-existing with Cranial Nerves Schwannoma and Meniere Disease: Case Report
Authors: Chua Wei De Kenneth
Published: March 2021

Benign Paroxysmal Positional Vertigo (BPPV) is characterized by intense positional provoked vertigo with a brief duration and is one of the most common types of peripheral vestibular problems. The most commonly affected semi-circular canal is the posterior canal with a greater prevalence seen in females between the ages of 71-80. BPPV has a 60% right ear predisposition with canalithiasis as the predominant type. Most cases are unilateral, although bilateral BPPV is not atypical when associated with falls with head trauma, ototoxicity or co-existing vestibulopathy. To our knowledge, reports on bilateral BPPV coexisting with bilateral progressive vestibulopathy are scant. We describe a case of bilateral posterior canal BPPV with definite Menieres Disease (MD), Vestibular Schwannoma (VS) secondary to a schwannoma arising from the Jugular Foramen (JF) with mass effect and an incidental schwannoma of the right orbital optic nerve. Underlying BPPV may mask other clinical presentations, making it challenging to diagnose co-existing vesitbulopathy, especially those of a progressive episodic nature. In making management decisions, this serves as a reminder for clinicians to have in-depth conceptual and procedural knowledge to recognise and focus on the insidious progressive pathologies and not be distracted by the easily treatable BPPV.
FIFA 11+ para Prevenção de lesões em jogadores de futebol: revisão de revisões
Authors:   Gil Vicente Futebol Clube, Barcelos., Pinto João , Gustavo Diogo , Lobo Ricardo ,   Gil Vicente Futebol Clube, Barcelos., Direito-Santos Bruno ,   Gil Vicente Futebol Clube, Barcelos.,   Gil Vicente Futebol Clube, Barcelos. Serviço de Ortopedia e Traumatologia do Hospital de Braga, Carvalho Paulo ,   ATC de Fisioterapia, Escola Superior de Saúde do Instituto Politécnico do Porto.
Published: March 2021

The purpose of this review of reviews is to assess if FIFA 11+ is effective for injury prevention in football. A search for systematic reviews published after 2014 was performed in the PubMed and PEDro databases and the included reviews were evaluated through the AMSTAR checklist. In total, four systematic reviews were included, three of them with meta-analysis. The quality of the evidence found is moderate to high quality. In conclusion, there is moderate to high evidence that using the FIFA 11+ protocol reduces the total number of injuries and specific lower limb injuries.
Degassing Parameters for High-Performance Working Areas at the Anexplored Mine Fields
Authors:   IPCON RAN, Zaburdayev V.S.
Published: March 2021

Conditions of the coal seams bedding at the mines of Kuzbass and Vorkutskoye deposits, their natural methane content and coal grades are studied in the article. Performance of shearers and the natural degassing effect of the second working on the change in the methane content of the massif in the coal mining zone are evaluated. Dependence is established concerning the coefficient of coal seams natural degassing on the thickness of the mined seam. The influence of natural and mining-technical factors on the efficiency of second working and degassing parameters were studied. The relationship is revealed between the natural methane content of coal seams with the yield index of the volatile substances contained in the coals of various grades. The relationship is defined related to the intensity of the initial methane release from the coal mass to the reservoir degassing wells depending on the natural methane content of the reservoir with the outgoing air flow. Comparison of the data obtained during geological exploration works, and the predicted values calculated based on the identified dependencies showed their good convergence. The dependences were revealed concerning the zones of intense methane release in the degassing wells on the thickness of the inter-layer of the unloaded adjacent layers in the roof and soil of the working layer in the process of moving the working face. This information allows to select the optimal mode of wells functioning for extracting methane-air mixtures suitable for utilization in the unexplored mine fields. Recommended coefficients of degassing of the methane emission sources were determined for ensuring the planned productivity of the working face with the view to ensure its safety on the gas factor.
Assessment of the Thermal Radiation Regime of the Crane Operator Workplace for Making the Reasonable Choice of the Climate System of the Metallurgical Crane Cabin
Authors:   FSBEI of HE «Don State Technical University», Meskhi B.Ch. , Bulygin Yu.I. ,   FSBEI of HE «Don State Technical University», Maslensky V.V. ,   FSBEI of HE «Don State Technical University», Loskutnikova I.N. ,   FSBEI of HE «Don State Technical University»
Published: March 2021

The tendency of increasing of radiation sources power in metallurgy leads to an increase in the level of thermal radiation at the crane operator workplaces. The state of their health is characterized by a decrease in physical performance, the occurrence of colds, and occupational diseases of the cardiovascular and respiratory systems. Therefore, it is necessary to evaluate the thermal radiation regime of the crane operator workplace for further justification of the choice of the method and means of thermal protection. To assess the thermal irradiation of the metallurgical crane cabin, along with the method of building the thermal irradiation plot, the finite element method was used which was integrated into the automated software package ANSYS, into its plug-in Fluid Flow (Fluent) designed to build models of convective energy transfer by a liquid or gas flow. Flow turbulence is described by the Shear Stress Transport (SST) model. The article examines the thermal radiation situation in the steelmaking shop, which determines the choice of means to ensure an optimal microclimate at the crane operator workplace. It was revealed that the thermal radiation and the temperature of the railings of the metallurgical crane cabin significantly exceed the maximum permissible level, as a result of which it became impossible to choose a climate system that provides for a comfortable air temperature inside the cabin. To reduce the thermal load on the designed climate system, thermal protection elements are introduced into the design of the metallurgical crane cabin, such as a heat-reflecting screen of the floor and side wall and double glazing of the front wall. Then a high-temperature industrial air conditioner was selected, the efficiency of which was confirmed by the results of computer simulation. Thus, for a reasonable choice of the climate system of a metallurgical crane cabin, it is required to have rational combination of the methods and means of thermal protection used at the equipment design stage.
Incisional Hernia Post Open Appendectomy: A Case Report
Authors: Otuu Onyeyirichi , Nnadozie Ugochukwu Uzodimma
Published: March 2021

Incisional hernia is an unusual postoperative complication after appendectomy through a McBurney’s incision with an incidence of less than one percent. We present a case of incisional hernia post open appendectomy in a 40-year old woman. She presented to us with a painless right lower abdominal swelling that developed after an emergency open appendectomy for perforated appendix 7 years earlier. She was clinically stable with BMI of 24.5 kg/m2. She had a non-tender, reducible mass of 20×16×8 cm protruding through a healed right iliac fossa transverse scar. She had an open onlay mesh repair with satisfactory outcome. Post appendectomy incisional hernia is uncommon. Hernioplasty offers a satisfactory outcome.
IMPACT OF EXTRACURRICULAR IN THE IMPROVEMENT OF HIGHER EDUCATION GRADUATES’ EMPLOYABILITY SKILLS: THE CASE OF TUNISIA
Authors:   Faculty of Economics and Management of Sfax, Tunisia, Mefteh Haifa
Published: March 2021

This paper investigates the impact of extracurricular activities (ECA) on developing employability skills of higher education graduates in Tunisia. In this regard, we use a quantitative survey that has been distributed to 451 graduates. The results of the logistic regression model show that participation in extracurricular activities (ECA) is the main determinant of soft skills development. In addition, Spearman's correlation analysis demonstrates a positive one between the acquisition of soft skills and participation in extracurricular activities. Each of the activities develops specific skills. We found that participation in social groups helps to develop more soft skills. Keywords: soft skills, employability skills, graduates, ECA, Tunisia.
PROMOSI PENJUALAN, STORE ATMOSPHERE, DAN BRAND IMAGE BERPENGARUH TERHADAP REPURCHASE INTENTION
Authors: Prakasa Restuputra Made Dio , Rahanatha Gede Bayu
Published: March 2021

Drinking coffee habit in Denpasar, creates an opportunity to attract consumers to repurchase intention. Factors that influence the occurrence of repurchase intention include sales promotions, store atmosphere, and brand image. Purpose of this study are to determine the effect of sales promotion, store atmosphere, and brand image on repurchase intention. This research is conducted on consumers Excelso Cafe products. Sample are 112 respondents with purposive sampling. Data collection is carried out by questionnaire, analyzed by multiple linear regression. Based on the results, sales promotions have a significant positive effect on repurchase intention, store atmosphere has a significant positive effect on repurchase intention, brand image has a positive and significant effect on repurchase intention. Sales promotion, store atmosphere, and a good brand image greatly affect repurchase intention. Excelso should pay more attention to sales promotions, store atmosphere, and brand image felt by consumers in order to increase repurchase intention from consumers.

Keywords: sales promotion, store atmosphere, brand image, repurchase intention
MENAKAR ASA OPTIMALISASI PROFIT MELALUI KONSEP “YUK NABUNG SAHAM”
Authors: Citasti Ni Nyoman , Darma Gede Sri
Published: March 2021

The pattern of public consumption has shifted towards an increasingly complex direction. Good financial management is aimed at ensuring financial security and development in the long term. One way to manage finances is by investing. The low literacy and utility of stocks which are worrying have even been followed up by the Indonesia Stock Exchange. Through the "Yuk Nabung Saham" campaign, the Indonesia Stock Exchange is pursuing a movement capable of encouraging an increase in the number of active investors (especially domestic investors) in the Indonesian capital market. The aim of this study is to determine a strategy to optimize stock investor profits by adopting the concept of "Yuk Saving Stocks". Data analysis in this study used qualitative methods. Research using qualitative methods departs from the phenomenon that occurs in the community itself. The 'Let's Save Stocks' campaign has benefits for the community, especially BNI Sekuritas customers. The resulting benefit is the start to open people's minds about investing in the capital market. We recommend that the stakeholders make policies that can invite or influence investors in stock transactions. This is due to the high number of additional investors, but this is not balanced by the number of transactions.

Keyword: Indonesia stock exchange, let's save stocks, stocks, capital market, IDX
PENGARUH LITERASI KEUANGAN DAN INKLUSI KEUANGAN TERHADAP KINERJA UMKM DI SIDOARJO
Authors: Septiani Risa Nadya , Wuryani Eni
Published: March 2021

Raising financial literation and inclusion of financial can developing small micro entrepreneurship (UMKM) because the agent of UMKM can undesrtand the basic concept of financial product, planning and good management financial, also protecting then from deception and unhealthy work from financial market. This research purposes to know the affection of financial literation and financial inclusion toward developing UMKM work in Sidoarjo area. This research is used ex-post facto with the quantitative approaching. The collected data of the research based on the interview and quetioner distribution with sampling technique which is simple random sampling. Technique of data analysis in this research is analysis of linier double regression with helping program SPSS computer. The result of this research can conclude that financial literation and financial inclusive prove that be an affected factor of developing work UMKM in Sidoarjo.

Keywords : Financial Literation, Financial Inclusion, Developing work of UMKM
PERAN STRATEGI KEPEMIMPINAN BIAYA MEMEDIASI ORIENTASI PASAR DAN ORIENTASI KEWIRAUSAHAAN TERHADAP KINERJA USAHA
Authors: Krisna Gede Andika , Giantari I Gusti Ayu Ketut
Published: March 2021

Tujuan penelitian ini adalah untuk menjelaskan peran strategi kepemimpinan biaya memediasi pengaruh orientasi kewirausahaan dan orientasi pasar terhadap kinerja Usaha Dodol di Kabupaten Buleleng. Penelitian ini dilakukan di Usaha Dodol di Kabupaten Buleleng. Ukuran sampel yang diambil sebanyak 160 Usaha Dodol, menggunakan (sensus). Pengumpulan data menggunakan kuesioner. Teknik Analisis menggunakan Structural Equation Modeling (SEM). Hasil analisis menunjukkan: 1) Orientasi pasar dan orientasi kewirausahaan berpengaruh positif dan signifikan terhadap kinerja Usaha, 2) orientasi pasar, orientasi kewirausahaan berpengaruh positif dan signifikan terhadap strategi kepemimpinan biaya, 3) strategi  kepemimpinan biaya berpengaruh positif dan signifikan terhadap kinerja Usaha, 4) strategi kepemimpinan biaya memediasi secara parsial pengaruh orientasi kewirausahaan dan orientasi pasar terhadap kinerja Usaha.

Kata kunci: kinerja usaha, orientasi kewirausahaan, orientasi pasar, strategi kepemimpinan biaya
REKRUTMEN, SELEKSI, PENEMPATAN DAN KINERJA KARYAWAN
Authors: Widnyani Ni Made
Published: March 2021

This research was conducted to determine the influence of the recruitment, selection, placement and performance of employees at PT. Bumi Sentosa which is still trusted to be the service provider, especially in the field of technical service. This research was conducted by analyzing the relationship between variables recruitment, selection, placement and performance of employees. This research was conducted by questionnaire method and the type of research is quantitative. Statistical analysis and hypothesis testing using Structural Equation Modeling (SEM) with Amos as the application program. Respondents in this research were employees of technical service at PT. Bumi Sentosa with a sample number of 110 people. The results showed that the influence of recruitment to the placement was significant, the influence of selection to the placement is significant, the influence of the placement to the employee's performance is significant, the influence of recruitment to employee performance is significant and the influence of selection to the performance of employees is significant too, which means the entire hypothesis is verified. This research shows that more better of recruitment, selection and placement conducted by PT. Bumi Sentosa, the performance of employees will more better too.

Keyword : recruitment, selection, placement, employee performance
PERANAN PERUSAHAAN DALAM MENINGKATKAN KEMAMPUAN KERJA PETERNAK DAN KUALITAS HASIL PANEN MADU DI MASA PANDEMI
Authors: Agustini I Gusti Ayu Ari
Published: March 2021

The Covid-19 pandemic has undeniably crippled the economy of the wider community. Beekeeping and its derivatives business are promising efforts during the current pandemic. Honey, which is one of its derivative products, has become a necessity that is most in demand by the public to maintain stamina and endurance. Currently the market demand for good quality honey is getting bigger, so that this opportunity is widely exploited by honey business actors. The purpose of this study was to analyze the efforts made by Bali Honey in improving the working ability of honey breeders in the midst of the Covid-19 pandemic and to analyze the strategies implemented to improve the quality of the honey harvest to bring benefits to the local community. The data analysis method is descriptive qualitative. Data analysis was carried out by collecting secondary data and primary data. The data and information obtained through field research are then analyzed by doing data reduction, namely summarizing the data from interviews and field observations, then interlinking them with the theoretical basis and literature review to get a final conclusion. The theoretical foundations used in the research are reinforcement theory, expectancy theory, and goal setting theory. The result of the research is that consistent education carried out by Bali Honey plays an important role in improving the working ability of honey farmers so that the quality of the yields produced can compete in the market.

Keyword : the role of the company, work ability, product quality
ПРОШИРЕЊЕ АЛАТА ЗА АУТОМТСКУ ДЕТЕКЦИЈУ ПРЕТЊИ СА CWE БАЗОМ ЗНАЊА И ЊЕГОВА УПОТРЕБА У РАЗВОЈУ БЕЗБЕДНОГ СОФТВЕРА
Authors: Шуњка Јово
Published: March 2021

У овом раду описан је алат за подршку SDL процеса и смернице за његову интеграцију у процес развоја безбедног софтвера.
GOOSE KOMUNIKACIJA
Authors: Cvijić Dajana , Stojanović Zoran
Published: March 2021

U radu su prikazani osnovi principi modelovanja u okviru IEC 61850 protokola i GOOSE komunikacija kao poseban dio samog protokola. Osim samog modelovanja podataka, prikazana je i GOOSE komunikacija između zaštitnih uređaja - releja. Opisana je i ispitana jedna primjena GOOSE komunikacije, koja se odnosi na blokadu zaštitnih funkcija releja, čime je ujedno dokazana njena funkcionalnost i prednosti ovakvog vida komunikacije.
INTEGRACIJA NEWWAVE WORKFLOW ENGINE-A I OPENPONK ALATA
Authors: Marković Milica
Published: March 2021

U radu je predstavljena integracija NewWave workflow engine i OpenPonk alata. Model je nacrtan u OpenPonk editoru za meta-modelovanje. Plugin je zadužen za parsiranje modela u jeziku specifičnom za domen i mapiranje na NewWave elemente.