bluuebunny/crossref_metadata_2025 huggingface dataset:
En más de un sentido: Multimodalidad y construcción de significados en traducción e interpretación
Authors: Martín de León Celia , Marcelo Wirnitzer Gisela
Published: July 2022

El concepto de “multimodalidad” alude a la interacción de diferentes modos semióticos en los procesos de producción de significados. La lengua hablada y escrita, los gestos, las imágenes estáticas y en movimiento, el sonido o la música son algunos de los modos semióticos que utilizamos para crear e interpretar significados. Para desempeñar su tarea, traductores, audiodescriptores, subtituladores o intérpretes necesitan saber cómo interactúan estos modos en la producción de significados. Los trabajos reunidos en este volumen abordan este tema e intentan responder, desde distintas perspectivas y ámbitos de estudio, a preguntas como las siguientes: ¿Cómo interactúan diferentes recursos semióticos en los procesos de construcción de significados de traductores e intérpretes? ¿Cómo podemos estudiar las interacciones y sinergias entre los distintos modos? ¿Cómo puede contribuir cada uno de los modos a facilitar la comprensión y la accesibilidad? ¿Cómo perciben los propios traductores e intérpretes su uso de los distintos modos en sus procesos de construcción de significados? Los estudios ofrecen un panorama multifacético de un fenómeno que está recibiendo cada vez mayor atención en los estudios de traducción e interpretación y que nos obliga a repensar y redefinir nuestro objeto de estudio.
Journal Management Services at Padjadjaran University Knowledge Management Center
Authors: Fikri Osama Muhammad , Rukmana Evi Nursanti , Sukaesih  , CMS Samson
Published: July 2022

The Open Journal System (OJS) in universities is used to increase university publications by providing open access to journals to keep knowledge alive. This study aims to determine the Open Journal System (OJS) service at the Knowledge Management Center of Padjadjaran University through collection analysis, retrieval system, and service model. This study uses descriptive qualitative research methods. The results showed that the Open Journal System collection of the Knowledge Management Center Universitas Padjadjaran amounted to 105 journals from 14 faculties. Each journal represents the scientific study program in each faculty. Users in the retrieval system can determine information from the articles they are looking for, use features, and determine the right query, information search results, and additional records of information search results. The Knowledge Management Center of Padjadjaran University provides information and consultation on journal indexation, and records journals, and provides guidance for journals that will apply for accreditation/reaccreditation. The OJS service model at the Unpad Knowledge Management Center has been carried out well using regular communication and sharing information with journal managers regarding journal management. The Unpad Knowledge Management Center has provided a good service model in the form of guidance, direction, or consultation regarding journal management to university journals.
Whistleblowing without names is hearsay
Authors: Healy David
Published: July 2022

Peter Gøtzsche’s proposal to provide anonymity to certain people reporting bad practices within the pharmaceutical industry, regulatory apparatus or health systems is superficially appealing but likely to generate more problems in the longer run than it might solve in the short term. We need to analyse what features of our systems generate problems and correct those, rather than rely on insiders to report on the resulting problems, as all these reports do is offer a false sense of security that things are safer now that one problem has been identified.
New records of the genus Rungia (Acanthaceae) from Vietnam
Authors:   Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of  Sciences, Guangzhou 510650, China, LIN ZHELI , THUY NGUYEN THU ,   Department of Botany, Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, 18 Hoang  Quoc Viet, Cau Giay, Hanoi 10072, Vietnam, HAI DO VAN ,   Department of Botany, Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, 18 Hoang  Quoc Viet, Cau Giay, Hanoi 10072, Vietnam, DENG YUNFEI ,   Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of  Sciences, Guangzhou 510650, China
Published: July 2022

Three species of Rungia are newly recorded from Vietnam, viz. R. burmanica, R. flaviflora and R. sinothailandica. Photographs, ecology, phenology and notes regarding each species are provided.
The Hunger Games as the Key to Happily Ever After?
Authors: Deere Jacques , Xu Clarice , Adelmant Celestine , Aboobaker Aziz , Salguero-Gómez Roberto
Published: July 2022

The world’s human population is reaching record longevities. Consequently, our societies are experiencing the impacts of prolonged longevity, such as increased retirement age. A major hypothesised influence on ageing patterns is resource limitation, formalised under calorie restriction theory. This theory predicts extended organismal longevity due to reduced calorie intake without malnutrition. However, several challenges face current calorie restriction (CR) research and, although several attempts have been made to overcome these challenges, there is still a lack of holistic understanding of how CR shapes organismal vitality. Here, we conduct a literature review of 222 CR peer-reviewed publications to summarise the state-of-the-art in the field. We use this summary to highlight challenges of CR research in our understanding of its impacts on longevity. Our review demonstrates that experimental research in this field is biased towards short-lived species (98.2% of studies examine species with <5 years of mean life expectancy) and lacks realism in key areas, such as stochastic environments or interactions with other environmental drivers such as temperature. We argue that only by considering a range of short- and long-lived species and by taking more realistic approaches can the impacts of CR on longevity be examined and validated in natural settings. We conclude by proposing experimental designs and study species that will allow the discipline to gain a much-needed understanding of how restricting caloric intake affects long-lived species in realistic settings. Through incorporating more experimental realism, we anticipate crucial insights that will ultimately shape the myriad of socio-bio-economic impacts of senescence in humans and other species across the Tree of Life.
MonkeyPox2022Tweets: The First Public Twitter Dataset on the 2022 MonkeyPox Outbreak
Authors: Thakur Nirmalya
Published: July 2022

The world is currently facing an outbreak of the monkeypox virus and confirmed cases have been reported from 74 countries. Following a recent “emergency meeting”, the World Health Organization just declared monkeypox a global health emergency. As a result, people from all over the world are using social media platforms, such as Twitter, for information seeking and sharing related to the outbreak, as well as for familiarizing themselves with the guidelines and protocols that are being recommended by various policy-making bodies to reduce the spread of the virus. This is resulting in the generation of tremendous amounts of Big Data related to such paradigms of social media behavior. Mining this Big Data and compiling it in the form of a dataset can serve a wide range of use-cases and applications such as analysis of public opinions, interests, views, perspectives, attitudes, and sentiment towards this outbreak. Therefore, this work presents MonkeyPox2022Tweets, an open-access dataset of more than 255,000 Tweets related to the 2022 monkeypox outbreak that were posted on Twitter since the first detected case of this outbreak on May 7, 2022. The dataset is compliant with the privacy policy, developer agreement, and guidelines for content redistribution of Twitter, as well as with the FAIR principles (Findability, Accessibility, Interoperability, and Reusability) principles for scientific data management.
Social Media Analytics: Application towards Social Media Marketing
Authors: Zulfiqar Shahzeb , Lakho Asadullah , Nizam Kehkashan
Published: July 2022

The role of Social Media Marketing (SMM) in marketing strategies is rapidly growing. Because the use of social media is growing, the industry of SMM will grow bigger in the coming years; the pace of this growth is faster than ever. To survive in the modern competitive world, effective use of SMM for a firm is a must; for that, every SMM channel needs to be used to its full potential. For a marketing campaign to be effective, there is a need for some metrics to measure the success of the SMM campaign. These metrics measure if the campaign is successfully implemented or not. This would help firms understand the market, gain a competitive advantage, and ultimately get a positive impact on the overall business. This study categorizes SMM strategy into 4 dimensions and associates 10 broad categories of SMM metrics to these dimensions. The proposed model of this study suggests the application of Social Media Analytics (SMA) ineffective use of metrics to measure SMM campaigns. There are so many SMA Tools available for free and time-efficient data analysis that can lead to faster and better results than manual analysis. Following this model, the importance of SMA tools in devising an effective SMM strategy is highlighted. The implication of this research is towards a better understanding of the application of SMA for any firm to have a solid SMM Strategy, especially small and medium-sized enterprises that have limited resources.
Community Knowledge, Attitudes and Practices Regarding Onchocerciasis in Rural Villages With a High Epilepsy Prevalence in Mahenge, Tanzania: A Qualitative Study
Authors: Bhwana Dan K. , Massawe Isolde S. , Mushi Adiel K. , Mashili Pendo , Amaral Luis-Jorge , Makunde Williams , Mmbando Bruno P. , Colebunders Robert
Published: July 2022

Despite of over 20 years of community directed treatment with ivermectin (CDTI), a high prevalence of onchocerciasis and onchocerciasis-associated epilepsy were observed in rural villages in Mahenge, Tanzania. Therefore, we assessed the knowledge, attitude and practice about onchocerciasis in four rural villages in the Mahenge area. This was a qualitative study conducted between June and July 2019. Eleven focus group discussions were organized with persons with epilepsy and their caretakers, community resource persons, and community drug distributors (CDDs), and two in-depth interviews with district programme coordinators of neglected tropical diseases (NTD). Most participants were aware about symptoms of onchocerciasis using local terminologies such as “ukurutu/rough dry skin” and “kuwashwa/itching”. A small proportion of people did not take ivermectin during CDTI for fear of adverse reactions such as itching and swelling. Some men believed that ivermectin may decrease libido. Challenges for high CDTI coverage included, long walking distance by CDDs to deliver drugs to households, persons being away for farming, low awareness of the disease and limited supervision by the NTD coordinators. In conclusion, ivermectin uptake in Mahenge should be optimised by continuous advocacy about the importance of taking ivermectin to prevent onchocerciasis-associated morbidity and by improving supervision during CDTI.
Metabolomic Aspects of Conservative and Resistance-related Elements of Response to Fusarium culmorum in the Grass Family
Authors: Piasecka Anna , Sawikowska Aneta , Witaszak Natalia , Waśkiewicz Agnieszka , Kańczurzewska Marta , Kaczmarek Joanna , Lalak-Kańczugowska Justyna
Published: July 2022

Background: Fusarium head blight (FHB) is a serious fungal disease of crop plants due to substantial yield reduction and production of mycotoxins in the infected grains. The breeding progress in increasing resistance with maintaining a high yield is not possible without a thorough examination of the molecular basis of plant immunity responses; Methods: LC-MS based metabolomics approaches powered by three-way ANOVA and differentially accumulated metabolites (DAMs) selection, correlation network and functional enrichment were conducted on grains of resistant and susceptible to FHB genotypes of barley and wheat as well as model grass Brachypodium distachyon (Bd) still poorly known at metabolomic level; Results: We selected common and genotype-specific DAMs in response to F. culmorum inoculation. Immunological reaction at metabolomic level was strongly diversified between resistant and susceptible genotypes. DAMs common for all tested species from porphyrins, flavonoids and phenylpropanoids metabolic pathways were highly correlated and reflects conservativeness in FHB response in Poaceae family. Resistant related DAMs belonged to different structural classes including tryptophan derived metabolites, pirimidines, amino acids proline and serine as well as phenylpropanoids and flavonoids. Physiological response to F. culmorum of Bd was close to barley and wheat genotypes however, metabolomic changes were strongly diversified. Conclusions: Combined targeted and untargeted metabolomics provides comprehensive knowledge about significant elements of plant immunity with potential of being molecular biomarkers of enhance resistance to FHB in grass family. Thorough examination of Bd21 metabolome in juxtaposition with barley and wheat diversified genotypes facilitate their setting as model grass for plant-microbe interaction.
Spot Charter Rate Forecast for Liquefied Natural Gas Carriers
Authors: Lyridis Dimitrios V.
Published: July 2022

Recent maritime legislations demand the transformation of the sector to greener and more energy efficient transportation. Liquified Natural Gas (LNG) seems a promising alternative fuel solution that could replace the conventional fuel sources. Various studies have been focused on the prediction of LNG price, however, no previous work has been made on the forecast of spot charter rate of LNG carrier ships. An important knowledge for the maritime industries and companies when it comes to decision-making. Therefore, this study is focused on the development of a machine learning pipeline to address the aforementioned problem by: (i) forming a dataset with variables relevant to LNG; (ii) identifying the variables that impact on the freight price of LNG carrier; (iii) developing and evaluating regression models for short and mid-term forecast. The results showed that the General Regression Neural Network presented a stable overall performance for 2, 4 and 6 months forecast.
Stochastic Thermal Load Dispatch Employing Opposition-based Greedy Heuristic Search
Authors: Singh Manmohan , Dhillon JS
Published: July 2022

A thermal load dispatch problem minimizes the number of objectives viz operating cost and emission of gaseous pollutants together while allocating the power demand among the committed generating units subject to physical and technological system constraints. A stochastic thermal load dispatch problem is undertaken while taking into consideration, the uncertainties, errors in data measurements and nature of load demand which is random. Owing to uncertain load demand, variance due to mismatch of power demand termed as risk, is considered as another conflicting objective to be minimized. Generally multiobjective problems generate a set of non-inferior solutions are generated and supplied to a decision maker to select the best solution from the set of non-inferior solutions. This paper proposes opposition-based greedy heuristic search (OGHS) method to generate a set of non-inferior solutions. Opposition-based learning is applied to generate initial population to select good candidates. Migration to maintain diversity in the set of feasible solutions is also based on opposition-based learning. Mutation strategy is implemented by perturbing the genes heuristically in parallel and better one solution is sought for each member. Feasible solutions are achieved heuristically by modifying the generation-schedules in such a manner that violation of operating generation limits are avoided. The OGHS method is simple to implement and provides global solutions derived from the randomness of the population generated without tuning of parameters. Decision maker exploits fuzzy membership functions to decide the final decision. Validity of the method has been demonstrated by analysing systems in different scenarios consisting of six generators and forty generators.
Comparison of Modern Cryptography Methods
Authors: Dutta Amandip
Published: July 2022

In this paper, different cryptography algorithms were reviewed, and their relative merits were discussed. Symmetric and asymmetric cryptography algorithms were compared for time and space efficiencies. These experiments were run to measure the execution time and the memory footprints of various algorithms to understand the implications of their real-life applications. In the experiment performed, it was observed that elliptic curve cryptography was the most efficient in terms of encryption/decryption time, as well as memory usage.
Network Analysis of the Disaster Response Systems in the Waste Recycling Center
Authors: Kim Su Dong , Park Jihwan
Published: July 2022

Since the process of waste recycling generates dust and flammable gas during fragmentation, there is always a risk of fire resulting therefrom, and fire does, in fact, frequently occur. However, research on disaster management at recycling facilities deals only with the problem of processing systems from a technical point of view, but it does not suggest concrete alternatives from a management point of view. Therefore, in this study, we analyzed the influence of the disaster response network of a waste recycling center at the organizational level based on the concept of the cognitive accuracy of a network when considering administrative aspects. Through this analysis, we confirmed that factors affecting the influence of the network exist, such that the entire network and the networks of different levels of position are different. We suggest that this can be improved by deploying members who perform formal tasks at the center of the network so that everyone can agree political approach.
Patterns and Risk Factors of Antibiotic Use in Poultry Farming and the Farmers: A Cross Sectional One-health Study in Pakistan
Authors: Habiba Um e , Khan Amjad , Mmbaga Elia John , Asaduzzaman Muhammad
Published: July 2022

Antimicrobial resistance (AMR) due to community carriage of antibiotic-resistant bacteria is highly prevalent in the WHO South-East Asia region. One of the major reasons is the misuse of antibiotics in animal farming practices and at community level, which threatens both human and animal health. However, this multifaceted One Health (OH) problem of antibiotic use (ABU) in poultry farms and respective farmers is not well studied in countries like Pakistan. Therefore, we conducted n OH cross-sectional study in rural Punjab to explore the current practices of ABU in poultry and poultry farmers, associated factors, their healthcare-seeking behaviour and biosecurity practices. We found all the participating farmers using antibiotics for poultry, 60% of which were Colistin sulphate and Amoxicillin trihydrate. The significant consumption of antibiotics in poultry farms (60%) and poultry farmers (50%) was without prescription. Most of the farms (85%) had no wastewater drainage system, causing direct shedding of poultry waste and antibiotic residue in the surrounding environment. Lack of farmers’ education, professional farm training and duration of farming experience were the significantly associated factors with ABU and knowledge of AMR. Our study implies the necessity of an integrated OH-AMR policy with the inclusion of farmers’ education, mass awareness, and strict antibiotic usage guidelines.
No Difference in Conversion Rate to Hip Arthroplasty After Intramedullary Nail or Sliding Hip Screw for Extracapsular Hip Fractures
Authors: Pyrhönen Helmi-Sisko , Lagergren Johan , Wolf Olof , Bojan Alicja , Mukka Sebastian , Möller Michael , Rogmark Cecilia
Published: July 2022

Background:

The widespread use of intramedullary nails (IMNs) compared with sliding hip screws (SHSs) in extracapsular hip fractures (AO/OTA 31-A1, 31-A2, 31-A3) has been questioned because of a higher complication rate, although the outcome might have improved through more recent implant designs and the learning curve. This study aimed to investigate if there is a difference with regard to the cumulative incidence of conversion to arthroplasty or any reoperation during the first 5 years after IMN or SHS fixation of extracapsular hip fractures.

Methods:

In this nationwide, observational cohort study, individuals who were ≥60 years of age and were registered in the Swedish Fracture Register (SFR) from 2012 to 2018 due to extracapsular fracture and were primarily treated with an IMN or SHS were followed in the SFR and the Swedish Arthroplasty Register (SAR) for a minimum of 1 year. The primary outcome was the cumulative incidence of conversion to arthroplasty (conversion rate). The secondary outcome was the cumulative incidence of all reoperations (reoperation rate). Both were calculated in a competing risk analysis during the first 5 years.

Results:

We included 19,604 individuals (70% women), with a median age of 85 years (range, 60 to 107 years). The 31-A2 fracture was most prevalent (52%), followed by the 31-A1 fracture (28%). No significant differences were seen in the 1-year conversion rate after IMN or SHS use (1.0% compared with 0.9% in the 31-A1 fractures, 1.7% compared with 1.3% in the 31-A2 fractures, and 1.3% compared with 1.5% in the 31-A3 fractures) or in the 1-year reoperation rate (1.9% compared with 1.9% in the type-A1 fractures, 3.4% compared with 2.5% in the type-A2 fractures, and 4.0% compared with 5.2% in the type-A3 fractures). Only in 31-A2 fractures were more reoperations seen after IMN use at 2 and 5 years (p < 0.05). The crude 1-year-mortality was 26.4% (5,178 of 19,604), without significant differences between implants.

Conclusions:

Considering conversion arthroplasty, IMNs and SHSs performed equally well in general. IMN use was associated with more reoperations than SHS use in 31-A2 fractures at 2 years. However, from a clinical perspective, the differences between the implants were small, in particular when considering the competing risk of dying.

Level of Evidence:

Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
FIRST SYMBIOTIC ASSOCIATION BETWEEN HEDERELLOIDS AND RUGOSE CORALS (LATEST SILURIAN OF SAAREMAA, ESTONIA)
Authors: VINN OLEV , WILSON MARK A. , MADISON ANNA , KAZANTSEVA ELIZAVETA , TOOM URSULA
Published: July 2022

A phoronid-like hederelloid that formed a symbiotic association with the rugosan coral Entelophyllum has been found in the Pridoli Series of Estonia. The skeletons of the hederelloid and rugosan are partially intergrown. The hederelloid apertures are located at the margin of the rugosan calice. The hederelloid lophophore was likely placed between the tentacles of the coral polyp, indicating a positive or at least a neutral co-existence. In extant corals, polyps can be retracted into the calice either during the day or night. If the rugose coral was similar to modern corals in this respect, it may have helped in the co-existence with the hederelloid and allowed feeding at different times. It is possible that the hederelloid soft tissues were protected against smaller predators by the stinging cells of the rugosan tentacles. The history of symbiosis in hederelloids is similar to that of tentaculitoids, in which symbiotic relationships also appeared early in their evolution. To date, Entelophyllum is the only colonial rugosan known to have formed symbiotic associations during the Silurian.
Extensions of phenomenology in Timothy Bayne’s works as a project in philosophy of mind
Authors:   Lomonosov Moscow State University, Yashin Artyom S.
Published: July 2022

There is an ongoing debate in the philosophy of mind about which mental states possess phenomenal character, and whether there are non-sensory and non-emotional phenomenal properties. One of the most famous experts on the questions of phenomenological rich­ness in analytic philosophy is British-Australian philosopher Timothy Bayne. In his works, T. Bayne considers several debatable domains of phenomenal states. These do­mains include cognitive phenomenology, the phenomenology of categorical perception, and the phenomenology of agency. However, the three domains are discussed in his works separately, so the relations between these domains within Bayne’s views on phe­nomenology are uncertain. In this study T. Bayne’s works on the debatable domains of phenomenology were analyzed, and the connections between the three domains were identified. This article shows that the matching content challenge put forward against the phenomenology of thought is equivalent to the impossibility of formulating a contrast argument for thought, and that in its turn formulating a contrast argument negates the matching content challenge. The study also found that in Bayne’s works the phe­nomenology of categorical perception and the phenomenology of agency are supported by varieties of contrast argument. The feature that makes these two domains of phe­nomenology different from sensory phenomenology and also makes them debatable is in­trospective elusiveness. Consequently, the article concludes that the states associated with categorical perception and manifestations of agency are extensions of the set of phenome­nal states, and not a basic part of it.
The “Northern” identity of Russia as a subject of civilizational self-criticism (from Pyotr Chaadaev to Vasily Shulgin)
Authors:   Institute of Philosophy, Russian Academy of Sciences, Kara-Murza Alexei A.
Published: July 2022

The article examines the question of the evolution of the philosophical and historical views of Russian intellectuals Pyotr Yakovlevich Chaadaev (1794–1856) and Vasily Vi­talievich Shulgin (1878–1976). It is noted that both of them largely depart from the usual definition of the civilizational identity of Russia in the coordinates “West-East” and pre­fer to operate with the dichotomy “North-South”. Revealing the “Northern” identity of Russia, primarily, both Chaadaev (in the nineteenth century) and Shulgin (in the twentieth century) act in the genre of civilizational self-criticism, believing the northern (Nordic) conditionality of our culture is not a dignity, but, on the contrary, a kind of “karma”, a “Сross” that Russia has to carry through centuries of history. P.Ya. Chaadaev focuses his attention primarily on the philosophical and historical aspects of the domestic “North­erners”, defining the Russian North as a place of “solidification” of Western-origin “meanings”. In turn, V.V. Shulgin focuses his attention mainly on the forms of national identity and psychology, considering the domestic “Northerners” as a way of “cooling” (and eventually – extinguishing) the national energy.
Non-philosophy and the limits of philosophy: G. Deleuze and F. Laruelle
Authors:   Ural Federal University named after the first President of Russia B.N. Yeltsin, Kerimov Tapdyg Kh.
Published: July 2022

The article analyzes two presentations of non-philosophy, which was the main subject of a discussion between Gilles Deleuze and Francois Laruelle. The context of actualiza­tion of non-philosophy, the principles and content of its implementation in the works of G. Deleuze and F. Laruelle are revealed. From the comparison and identification of controversial points inherent in these two views, the hypothesis of the positive limit of philosophy is singled out. The latter, in contrast to the appropriated and abolished nega­tive limit, points not to the incompleteness of philosophy and the intensification of its totalizing aspirations, but to its inconceivable possibility. The author shows that for­mally and structurally, the non-philosophies of G. Deleuze and F. Laruelle are identical. In non-philosophy, we are not talking about the end or overcoming of philosophy. Non-philosophy is not antiphilosophy, not the exteriority or the other of philosophy, but a “foundation”, an unthinkable place to which philosophy always already belongs, but which it is unable to describe. The discrepancy between the two presentations of non-philosophy is most clearly manifested when discussing this unthinkable place. For F. Laruelle, this unthinkable place is the radical immanence of the One-Real; for G. Deleuze, the plane of immanence bordering on chaos. The article concludes that the projects of non-philosophy, with all their differences, reveal the fundamental princi­ple of insufficient philosophy. On the one hand, no form of description can exhaust the multiplicity of the real. On the other hand, the possibilities of thought are irreduc­ible to the idiom of philosophical cognition. The plurality of descriptions raises before us the question of their combinations, the forms of their interaction, the language of their mutual understanding.
The Mechanisms of the Golden Rule of Morality and the Economic Policy of Today’s Russia
Authors:   Central Economics and Mathematics Institute, Russian Academy of Sciences, Zhukovskaya Lidiya V.
Published: July 2022

The article analyzes the interaction of national economic, legal and social macrosystems as a complex metasystem, justifies and solves the problem of their balance (equilibrium) based on the Berger equilibrium concept, which is a mathematical reflection of the Golden Rule of Morality. The influence of morality, understood in the sense of Kant’s imperative or the Golden Rule of Morality, close to it, on the process of strategic decision-making in the national complex metasystem is considered. A Nash equilibrium model of the three considered macrosystems is described as a reflection of the currently applied neoliberal economic doctrine. Using systems theory and game theory an alternative to it moral-philo­sophical economic doctrine (based on the Golden Rule of Morality) is substantiated. Rele­vant is the description of the model of system equilibrium of the complex metasystem on the basis of the Golden Rule of Morality to determine effective strategic decisions under conditions of uncertainty in the social sphere, which reflects the ideas of building a social state. The research is multidisciplinary as it uses synthesis of scientific approaches of sys­tems analysis, philosophical ethics, economics, law, sociology, game theories, manage­ment and systems.
TMBIM1 promotes EMT by stimulating autophagic degradation of E-cadherin via AMPK/mTOR/ULK1 axis in human gliomas
Authors: Gao Lun , Liu Junhui , Zhang Shenqi , Li Yong , Tan Yinqiu , Yang Ji’an , Cai Jiayang , Wang Long , Ye Zhang , Tong Shi’ao , Deng Gang , Cai Qiang , chen qianxue
Published: July 2022

Glioblastoma (GBM, WHO grade IV) is well known for its highly metastatic and recurrent and accounts for approximately 50% of all gliomas. Dysregulation of epithelial–mesenchymal transition (EMT) can lead to malignant progression of GBM. Therefore, it is urgently needed to illustrate the mechanisms by which molecular drivers the EMT in GBM. We found for the first time that Transmembrane BAX inhibitor motif-containing 1 (TMBIM1) was over-expressed in gliomas compared with non-tumor brain tissues and increased as glioma malignancy progressed. Patients with high TMBIM1 expression had shorter overall survival time than those with low TMBIM1 expression. Importantly, TMBIM1 obviously induced EMT and autophagy, and inhibition of autophagy could reverseTMBIM1-induced EMT both in vitro and in vivo assays. TMBIM1 induced EMT by downregulating E-cadherin expression, which was proceeded by inhibiting the autophagic degradation of E-cadherin. Inhibition of TMBIM1 dramatically decreased the expression of P-AMPKα Thr172 and P-ULK1 Ser317 in U87 and U251 cells, and upregulated the expression of P-mTOR at Ser2448. We revealed that TMBIM1 enhanced the EMT and promoted autophagic degradation of E-cadherin via AMPK/mTOR/ULK1 axis both in vitro and in vivo. Our study provides a novel mechanism for the regulation of EMT in the process of gliomas metastasis, indicating that suppression of TMBIM1 activity to attenuate autophagy may be a potential strategy for the treatment of gliomas.
Construction of Azaheterocycles via Pd-Catalyzed Migratory Cycloannulation Reaction of Unactivated Alkenes
Authors: Wang Jin-Ping , Song Shuo , Wu Yichen , Wang Peng
Published: July 2022

Azahetereocycles constitute important structural components in many biologically active natural compounds and marketed drugs, and represent the most promising scaffolds in drug discovery. Accordingly, the development of efficient and general synthetic methods for the construction of diverse azaheterocycles is the major goal in synthetic chemistry. Although there have been notable advances in transition metal catalyzed formal [n+2] reaction with alkenes in which the cyclization normally occurred in the vicinal 1,2-position of those alkenes, significantly fewer migratory cycloannulation processes have been reported due to the low reactivity of the unactivated nonconjugated alkenes, unavoidable Heck-type byproducts, and the difficulties for controlling the cyclization position along the carbon chain of the alkenes during the metal migratory process. Herein, we report the efficient construction of a wide range of azaheterocycles via a Pd-catalyzed migratory cycloannulation strategy with unactivated alkenes by overcoming aforementioned limitations. This novel strategy enables the rapid construction of a series of 6-, 7- and 8-membered azaheterocycles in high efficiency, and features broad substrate scope, excellent functional group tolerance under redox-neutral conditions. The significance of this finding is demonstrated by the efficient synthesis of drug-like molecules with high step-economy. Preliminary mechanistic investigations reveal that this reaction underwent a sequentially migratory insertion to alkenes, metal migration process, and the aza-Michael addition to a quinone methide intermediate.
The identification of copy number variations in upland cotton using a high-density SNP array
Authors: Ma QingShan , Tao ZhiXin , Du Xiao , Moming Maimaiti , Ai XianTao
Published: July 2022

Background
Upland cotton (Gossypium hirsutum) is one crucial natural textile fiber and oilseed crop worldwide. Copy number variation (CNV) represents a form of genomic structural variation underlying phenotypic diversity. Understanding the genomic CNVs of Upland cotton is important for accelerating cotton breeding programs.Therefore,the present study generated a CNV regions (CNVRs) map in Upland cotton using the SNP array-based approach. The roles of CNVs identified were explored based on GO enrichment analysis of genes located in CNVRs.
Results
we used the Illumina Cotton SNP 70K BeadChip array for genome-wide detection of CNVs in 288 Upland cotton accessions. A total of 341 CNVRs were detected, representing approximately 2.0% of the entire cotton genome. Of these, 264 were gains, 55 were losses, 22 were events with gains and losses within the same region. The average length of CNVRs was 125.5kb and the median length was 80.4kb.The gene ontology (GO) enrichment analysis revealed that genes associated with metabolic process, catabolic process, multiple enzyme activities and transcription regulator activity were significantly overrepresented.
Conclusions
The findings that 90.3% of CNVRs harbored genes indicated the critical roles of CNVs in cotton. we identified two intriguing candidate biological process terms, polysaccharide metabolic process and catabolic process, related to cotton fiber development. Our research characterized the first landscape of CNVRs in cotton, providing an important resource for investigations of cotton genetic variability. It will facilitate further researches of molecular mechanisms underlying CNV-associated traits and improve our knowledge of genomic structure of cotton.
Increased Sample Size Proved More Insights for the Population Structure of Mediterranean Loggerhead Sea Turtles
Authors: Kaska Arzu , Koç Gizem , Sözbilen Dogan , Diryaq Salih , Glidan Ashraf , Elsowayeb Abd Alati , Saied Almokhtar , Margaritoulis Dimitris , Theodorou Panagiota , Rees Alan F. , Snape Robin , Broderick Annette , Godley Brendan , Beton Damla , Ozkan Meryem , Jr Imed , Ismail Manel Ben , Hmida Ahmed Ben , Badreddine Ali , Sacdanaku Enerit , Rae Vicky , Abdelwarith Mohamed Said , Naguib Nahla , Nakhla Lobna Ben , Limam Atef , Abderrahim Marwan , Sémelin Julien , Kaska Yakup
Published: July 2022

The loggerhead sea turtle (Caretta caretta), has the broadest distribution among sea turtle species in the Mediterranean and requires regional and international collaborations in addition to local efforts to better inform conservation actions. Molecular techniques are powerful tools to assess population dynamics at large scales, especially by determining the connectivity among different nesting and foraging sites, and genetic diversity. In this study, a large sample was collected synchronously in the nesting areas located in the north, south and east of the Mediterranean. Recently described nesting sites from Albania and other nesting sites represented by lower sample size were also included in order to fully assess the genetic composition of the region’s rookeries. Samples from 710 individuals were collected and the longer (815 bp) mtDNA D-loop fragment of these samples was amplified. We recorded 15 haplotypes, three of which were novel. In addition, our results show that some haplotypes, considered of Atlantic origin, have a wider dispersal in the Mediterranean than previously thought, albeit with low levels of representation. Our results, which also contribute to determining the likely origin of haplotypes that were previously known only from foraging sites, highlight the utility of broad-scale sampling, with increased sample number and longer mtDNA sequence to determine genetic diversity and connectivity. This study also demonstrates that it is important to continue to monitor the contribution of Atlantic origin haplotypes to the Mediterranean population, and the resident Mediterranean population, which is expected to expand its geographical range for reproduction with the effect of climate change and climate change in the long term. This work is important for, among other things, mixed stock analyses (MSA) that seek to localize the origin of stranded or accidentally caught sea turtles or those purposefully obtained from foraging sites to better understand the migratory distribution for conservation purposes.
Transgenerational herbivory effects on performance of clonal offspring of the invasive plant Alternanthera philoxeroides
Authors: Dong Bi-Cheng , Fu Qiu-Yue , Yu Cheng-Ling , Dong Ran , Shi Juan , Luo Fang-Li , Gao Jun-Qin , Yu Fei-Hai
Published: July 2022

Interactions between alien plants and the newly emerging enemies in introduced ranges may determine plant invasion success. However, little is known about whether herbivory-induced responses are transmitted across vegetative generations of plants, and whether epigenetic changes are involved during this process. In a greenhouse experiment, we examined the effects of current, parental and/or grand-parental herbivory by the generalist herbivore Spodoptera litura on the growth, physiology, and biomass allocation, and the status of DNA methylation of the first-, second- and/or third-generation clonal offspring of the invasive plant Alternanthera philoxeroides, which were derived from two types of root fragments with different branching orders (i.e., the primary- or secondary-root fragments of taproots). Parental herbivory promoted the growth of the second-generation plants sprouted from the secondary-root fragments, but had a neutral or negative effect on the growth of the second-generation plants from the primary-root fragments. The growth of the third-generation plants was significantly reduced by current herbivory, but not affected by grand-parental herbivory. The first-generation plants exhibited a higher level of DNA methylation when they were grazed by herbivores than when they were not, while neither the second-generation nor the third-generation plants showed the herbivory-mediated changes in DNA methylation. Overall, the herbivory-induced growth response within one generation may represent rapid acclimatization of A. philoxeroides to the unpredictable generalist herbivores in the introduced ranges. Herbivory-induced trans-generational effects may be transient for clonal offspring of A. philoxeroides, which can be influenced by the branching order of taproots, but be less characterized by DNA methylation.
Expression of DNA-repair genes and its relevance for DNA repair in peripheral immune cells of patients with posttraumatic stress disorder
Authors: Behnke Alexander , Mack Matthias , Fieres Judy , Christmann Markus , Bürkle Alexander , Moreno-Villanueva Maria , Kolassa Iris-Tatjana
Published: July 2022

Posttraumatic stress disorder (PTSD) involves elevated levels of cellular oxidative stress which jeopardizes the integrity of essential cell compartments. Previously, we demonstrated higher levels of DNA lesions in peripheral blood mononuclear cells (PBMCs) in PTSD. Retaining vital levels of DNA integrity requires cells to mobilize compensatory efforts in elevating their DNA-repair capacity. Accordingly, we hypothesized to find increased expression rates of the DNA-repair genes X-ray repair cross complementing 1 (XRCC1), poly (ADP-ribose) polymerase 1 (PARP1), and polymerase β (Polβ) in PBMCs of PTSD patients as compared to controls, leading to functionally relevant changes in DNA-repair kinetics. In a cohort of 14 refugees with PTSD and 15 without PTSD, we found significantly higher XRCC1 expression in PTSD patients than controls (U = 161.0, p = .009, Cohen’s r = .49), and positive correlations between the severity of PTSD symptoms and the expression of XRCC1 (rS = .57, p = .002) and PARP1 (rS = .43, p = .022). Higher XRCC1 (F = 2.39, p = .010, η²p = .10) and PARP1 (F = 2.15, p = .022, η²p = .09) expression accounted for slower repair of experimentally X-ray irradiation-induced DNA damage, highlighting the possible physiological relevance of altered DNA-repair gene expression in PTSD. Our study provides first evidence for a compensatory regulation of DNA-repair mechanisms in PTSD. We discuss the implications of increased DNA damage and altered DNA-repair mechanisms in immune senescence, premature aging, and increased physical morbidity in PTSD.
A Conceptual Framework for Software Reliability Testing
Authors: Faiz Rizwan Bin , Rauf Abdul
Published: July 2022

Testing Non Functional Requirements (NFR) is critical for the success of software project. Among all NFR, software reliability testing is an ongoing challenge for software in general and safety critical systems in particular. Since software reliability, as a quality attribute, cannot be tested as a whole it therefore is decomposed in to sub factors e.g. availability, correctness, fault tolerance etc. each of which can be measured through set of metrics. One fundamental way to associate sub factors against metrics is through a conceptual framework. Existing frameworks in literature for software reliability testing have variation in sub factors and corresponding metrics through statistical evaluation. There is a need to identify and correlate sub factors and their corresponding metrics against software reliability testing. The association should be performed in a schematic way based upon empirical data gathered from target population i.e. reliability testers from global software industry. Since the conceptual framework is proposed to global software industry we therefore identified sub factors and their corresponding metrics from a sample of 81 global software reliability testing experts. All empirical data was evaluated through statistical analysis i.e. correlation and binary logistic regression. The data was also validated by a focus group of 11 experts who had up to 20 years of experience and had numerous certifications in the domain of reliability testing. A conceptual framework for reliability testing in which 33 metrics are correlated with maturity, 10 metrics are correlated with availability, 3 metrics are correlated with fault tolerance, 7 metrics are correlated with recoverability and 5 metrics are correlated with correctness are represented through a schematic relationship in hierarchical structure. A conceptual framework for reliability testing is designed which will not only facilitate in understanding of relationship between the sub factors and their corresponding metrics, it will also help in designing more effective test cases and their measurement through a set of relevant metrics. Statistical evaluation of sub factors and their corresponding metrics with reliability testing was evident through correlation analysis as their p-value < 0.05 and regression analysis since all sub factors and their corresponding metrics had positive coefficient.
Circ_0072088 mediates hepatic fibrosis renders epithelial to mesenchymal transition through miR-330-3p/CDK1 axis in AML12 hepatocytes
Authors: Liu Mengmeng , Xing Yue , Jin Yao , Liu Shuang , Teng Xue , Zhi Duo , Zhong Lu , Dong Mei
Published: July 2022

Hepatic fibrosis was one of the causes to hepatocellular cancer (HCC), owing to limited therapeutic options. And hepatocytes can induce liver fibrogenesis via epithelial-mesenchymal transition (EMT). Multiple circRNAs exert critical role in the occurrence of liver fibrosis via working as microRNA (miRNA) sponges. Circ_0072088 is upregulated in hepatocellular cancer (HCC) and promote proliferation, migration of HCC cells. However, the potential research mechanism for circ_0072088 action against the fibrotic progression remain still unknown. The treatment of AML12 hepatocytes with TGF-β1 contributed to dramatically increased in the levels of circ_0072088. Additionally, in terms of mechanism, circ_0072088 was authenticated to function as miR-330-3p sponge, not only noticeable increase EMT, but also induced fibrosis in AML12 hepatocytes. MiR-330-3p could weaken the roles of circ_0072088 acceleration. Moreover, we proved that CDK1, a miR-330-3p target, was time-dependently augmented in the TGF-β1 treated AML12 hepatocytes, and its overexpression weakens the miR-330-3p regulatory effects.Our findings provided a unique role of the circ_0072088 mediates hepatic fibrosis renders epithelial-mesenchymal transition at least partially through miR-330-3p/CDK1 axis, thus suggesting its tremendous therapeutic potential in the treatment of liver diseases.
A Novel Method to Detect Cyber Attacks in IoT/IIoT Devices on the Modbus Protocol using Deep Learning
Authors: Gueye Thierno , Wang Yanen , Rehman Mudassar , Mushtaq Ray Tahir
Published: July 2022

The dominant Intrusion Detection Models in IoT/IIoT cybersecurity use network-based datasets. This paper proposes an architecture that consistently outperforms the state-of-the-art methods of performing Intrusion Detection that includes binary classification of whether an intrusion occurred or not and multi-class classification that classifies the different types of attacks. Three neural networks are designed with and without the proposed architecture. All experiments performed in this paper conclude that the proposed architecture performs consistently better than the control neural networks. This paper shows that a neural network with an embedding function can effectively be used to model whether an attack occurred on a device and the class of attack that occurred.