bluuebunny/crossref_metadata_2025 huggingface dataset:
Sámi traditional ecological knowledge as a guide to science: snow, ice and reindeer pasture facing climate change
Authors: Riseth Jan Åge , Tømmervik Hans , Helander-Renvall Elina , Labba Niklas , Johansson Cecilia , Malnes Eirik , Bjerke Jarle W. , Jonsson Christer , Pohjola Veijo , Sarri Lars-Erik , Schanche Audhild , Callaghan Terry V.
Published: January 2011

Scientific studies of challenges of climate change could be improved by including other sources of knowledge, such as traditional ecological knowledge (TEK), in this case relating to the Sámi. This study focuses on local variations in snow and ice conditions, effects of the first durable snow, and long term changes in snow and ice conditions as pre-requisites for understanding potential future changes. Firstly, we characterised snow types and profiles based on Sámi categories and measured their density and hardness. Regression analysis showed that density can explain much of the variation in hardness, while snow depth was not significantly correlated with hardness. Secondly, we found that whether it is dry/cold or warm/wet around the fall of the first durable snow is, according to Sámi reindeer herders, crucial information for forecasting winter grazing conditions, but this has had limited focus within science. Thirdly, elderly herders’ observations of changes in snow and ice conditions by ‘reading nature’ can aid reinterpretation of meteorological data by introducing researchers to alternative perspectives. In conclusion we found remarkable agreement between scientific measurements and Sámi terminology. We also learnt that TEK/science cooperation has much potential for climate change studies, though time and resources are needed to bridge the gap between knowledge systems. In particular, TEK attention to shifts in nature can be a useful guide for science.
Abnormalities in connectivity of white-matter tracts in patients with familial and non-familial schizophrenia
Authors: Wang Q. , Deng W. , Huang C. , Li M. , Ma X. , Wang Y. , Jiang L. , Lui S. , Huang X. , Chua S. E. , Cheung C. , McAlonan G. M. , Sham P. C. , Murray R. M. , Collier D. A. , Gong Q. , Li T.
Published: January 2011

Background

Abnormalities in the connectivity of white-matter (WM) tracts in schizophrenia are supported by evidence from post-mortem investigations, functional and structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). The aims of this study were to explore the microstructural changes in first-episode schizophrenia in a Han Chinese population and to investigate whether a family history of psychiatric disorder is related to the severity of WM tract integrity abnormalities in these patients.

Method

T1-weighted MR and DT images were collected in 68 patients with first-episode schizophrenia [22 with a positive family history (PFH) and 46 with a negative family history (NFH)] and 100 healthy controls. Voxel-based analysis was performed and WM integrity was quantified by fractional anisotropy (FA). Cluster- and voxel-level analyses were performed by using two-sample t tests between patients and controls and/or using a full factorial model with one factor and three levels among the three sample groups (patients with PFH or NFH, and controls), as appropriate.

Results

FA deficits were observed in the patient group, especially in the left temporal lobe and right corpus callosum. This effect was more severe in the non-familial schizophrenia than in the familial schizophrenia subgroup.

Conclusions

Overall, these findings support the hypothesis that loss of WM integrity may be an important pathophysiological feature of schizophrenia, with particular implications for brain dysmaturation in non-familial and familial schizophrenia.
Gift and Communio: The Holy Spirit in Augustine's De Trinitate
Authors: Kotsko Adam
Published: January 2011

This article traces the role of the Holy Spirit throughout Augustine's De Trinitate. After situating Augustine's treatise in terms of texts of Athanasius and Basil on the Holy Spirit, it treats the place of the Holy Spirit in his critique of the existing dogmatic terminology and the distinction between the economic and immanent Trinity. In contrast with the dominant Western and Eastern traditions, for Augustine the Holy Spirit comes to be thought of as God in a privileged sense, that is, as the person of the Trinity who is the most proper bearer of certain privileged names of God, most notably love. The notion of the Holy Spirit as eternal ‘gift’ proves to be especially troubling for Augustine, but also especially productive, and the present reading explicates the complex interrelationships that he is forced to develop among the concepts of love, cupiditas, gift, communio and enjoyment. The analysis of the concept of enjoyment in particular leads to the claim that the notion of property or ownership is completely foreign to God and that the Holy Spirit as communio must be thought as ‘gift’ only insofar as it is disruptive of the realm of ownership, that is, the realm of sin. The article finishes, as the De Trinitate does, with the implications of Augustine's treatment of the Holy Spirit for ethics and ecclesiology.
Talking politics, talking forgiveness
Authors: Barnes L. Philip
Published: January 2011

The aim of this article is to provide a provisional review and evaluation of recent Christian endorsements of the notion of political forgiveness. Attention is given to the doctrine of forgiveness in the New Testament and to its distinctive theological grammar. The chief theological features of Christian accounts of political forgiveness are outlined, before a number of weaknesses in the literature are identified and discussed. The implication of our discussion is that Christian love is expressed in two different ways, that of forgiveness upon repentance within the church and that of justice tempered by mercy in the socio-political realm.
The algebraic logic of kinship terminology structures
Authors: Read Dwight W.
Published: January 2011

Jones' proposed application of Optimality Theory assumes the primary kinship data are genealogical definitions of kin terms. This, however, ignores the fact that these definitions can be predicted from the computational, algebralike structural logic of kinship terminologies, as has been discussed and demonstrated in numerous publications. The richness of human kinship systems derives from the cultural knowledge embedded in kinship terminologies as symbolic computation systems, not the post hoc constraints devised by Jones.
Conceptual structure is constrained functionally, not formally
Authors: Hudson Richard
Published: January 2011

Kinship systems are best explained functionally, in terms of the conflicting needs of the society concerned, rather than in terms of universal constraints, whether Optimality Theory or other; but OT is particularly unsuitable as it rules out taxonomies. A conceptual analysis of kinship terminology shows, not that “grammar” extends to kinship, but that general cognition has the formal power to handle grammar.
Conceptual implications of kinship terminological systems: Special problems and multiple analytic approaches
Authors: Kronenfeld David B.
Published: January 2011

I raise issues concerning Jones' Seneca analysis, its relationship to analyses of Dravidian-, Crow-, and Omaha-type systems. These affect the convincingness of his kinship study, and thus the wider conclusions that he wants to draw regarding human cognition and language.
Advancing our grasp of constrained variation in a crucial cognitive domain
Authors: Levinson Stephen C.
Published: January 2011

Jones's system of constraints promises interesting insights into the typology of kin term systems. Three problems arise: (1) the conflation of categories with algorithms that assign them threatens to weaken the typological predictions; (2) OT-type constraints have little psychological plausibility; (3) the conflation of kin-term systems and kinship systems may underplay the “utility function” character of real kinship in action.
Lexical universals of kinship and social cognition
Authors: Wierzbicka Anna
Published: January 2011

Jones recognizes the existence of “primitives of conceptual structures,” out of which “local representations of kinship are constructed.” NSM semantics has identified these primitives through a cross-linguistic search for lexical universals (“NSM” stands for Natural Semantic Metalanguage and also for the corresponding linguistic theory). These empirical universals provide, I argue, a better bridge between cognitive anthropology and evolutionary psychology than the abstract constructs of OT, with dubious claim to conceptual reality.
Space, kinship, and mind
Authors: Bennardo Giovanni
Published: January 2011

In this commentary, I focus on Jones' suggestion of a close connection between the domain of space and that of kinship. I expand on that suggestion by introducing the concept of frame of reference and show how it can possibly participate to the generation of kinship systems.
Getting the constraints right
Authors: McConvell Patrick
Published: January 2011

While the idea of applying Optimality Theory to kinship has potential, this commentary draws attention to problems with the constraints proposed. Particularly, Distinguish Matrikin appears to recapitulate an error of linking matrilineal descent to Iroquois kinship too closely and more generally mixing descent with true kinship parameters.
Genealogy (and the relationship between opposite-sex/same-sex sibling pairs) is what kinship is all about
Authors: Salazar Carles
Published: January 2011

What are the theoretical implications of a universal genealogy? After the demise of relativism in kinship studies, there is much to be gained by joining old formal-structural analysis of kinship to recent cognitive-evolutionary approaches. This commentary shows how the logic of kinship terminologies, specifically those of the Seneca-Iroquois, can be clarified by looking at the relationship between opposite-sex/same-sex sibling pairs.
Dominance, proficiency, and second language grammatical processing
Authors: Birdsong David
Published: January 2011

Clahsen and Felser (CF) deserve praise for their superlative synthesis of literature relating to grammatical processing, as well as for their original contributions to this area of research. CF “explore the idea that there might be fundamental differences between child L1 and adult L2 processing.” The researchers present evidence that adult second language (L2) processing is often less automatic and less efficient than first language (L1) processing. Qualitative differences are suggested as well. Adult L2 processing may be restricted to shallow computations, whereas L1 processing typically involves detailed representations. These conclusions are reached in large part by comparing highly proficient L2 learners with natives on various neurological and behavioral dimensions of processing. I propose that additional comparisons might be carried out that involve an understudied population: learners whose L2 is their dominant language.
How do you like your doughnuts?
Authors: Duffield Nigel
Published: January 2011

Ever since the derivational theory of complexity (DTC) apparently bit the dust in the late 1960s, experimental psycholinguistics have been afflicted by a dualism at least as troublesome as the mind/brain dichotomy, namely, the grammar/parser distinction. The idea that mentally represented grammar is something fully dissociated from the human language processor is less than compelling, yet it has implicitly informed much of the last half century's psycholinguistics practice on both sides of the formalist–functionalist divide.
Commentary on Clahsen and Felser
Authors: Frenck-Mestre Cheryl
Published: January 2011

Clahsen and Felser (CF) have written a fairly comprehensive review of the current literature on on-line second language (L2) processing, presenting data from eye movement, self-paced reading, and event-related potential (ERP) studies with the aim of evidencing possible differences between native language (L1) and L2 processing. The thrust of the article, in regard to adult L2 processing, is apparently an attempt to gather evidence to bolster their argument about “shallow processing” in adult L2 learners. Although the authors provide the reader with a generally good overview of the current literature, their argumentation seems to be flawed at times. Consider, first, the authors' presentation of recent ERP evidence. The authors claim that L2 adult learners may lack automaticity in comparison to native speakers in regard to syntactic processing. This is based upon a delayed N400 response, often found in L2 learners compared to native speakers, as well as by the pattern of anterior negativities to morphosyntactic violations. Later, however, this line of argumentation is seemingly undermined. First, as CF rightly underline, the range of variability in anterior negativities found in L2 learners falls within the range of variation observed in native speakers. As such, variability in this response cannot be taken as a marker of differential processing specific to (shallow) syntactic processing in the second language (see also Frenck-Mestre, 2005; Osterhout et al., 2004). Second, as CF later note, the N400 (as well as P600) is systematically observed in adult L2 learners, and is often highly similar to that found for native speakers. Consider, next, the behavioral evidence cited by CF on adult L2 syntactic processing. The authors cite work on various structures, notably relative clause attachment (which has received a great deal of attention in both monolingual and L2 studies). Concerning this structure, although CF cite studies, which show both clear L1 influence on L2 processing and differential effects as a result of experience with the L1, they favor studies that fail to show such effects and reject Mitchell et al.'s (2000) tuning hypothesis as an explanatory model. (Note Mitchell and colleagues have indeed produced evidence of their own showing limitations of their model.) It is also noteworthy that CF's argumentation about the sensitivity of the measure they used to test for immediate preferences for this structure is not as strong as it could be. Indeed, where they report L2 preferences (for low attachment following thematic prepositions), the literature shows the same systematic preference independent of the language tested (cf. Mitchell et al., 2000). As such, the sensitivity of their measure may not be adequately demonstrated. In sum, although CF provide the reader with an impressive collection of current L2 studies, the viewpoint that they espouse does not seem to be as substantiated as they wish to claim.
How language learners comprehend and produce language in real time
Authors: Libben Gary
Published: January 2011

This paper does a fine job of advancing discussion concerning a question that is indeed quite underrepresented in the literature, that is, how language learners comprehend and produce language in real time. The paper is firmly rooted in the dual mechanism approach to language processing and takes as its starting point the assumption that normal adult processing is characterized by two systems, one that is lexically based and one that is essentially combinatorial. The authors cite evidence that both first language (L1) learners and adult native speakers show evidence of dual mechanism processing and that, in particular, children's sentence processing shows early reliance on structure-based interpretation and less ability to employ lexical/pragmatic information in the resolution of language ambiguity. One way to view this preference is that L1 learners might know, broadly speaking, considerably more about their language than they do about the world in which they live. Adult second language (L2) learners might be said to be in exactly the opposite situation. It is therefore hardly surprising that adult L2 speakers rely strongly on lexical/pragmatic cues in sentence processing. In the early stages of adult L2 acquisition, the demands of real-time processing make use of such nonsyntactic inference crucial. The question that strikes me as key is whether, as L2 speakers become more proficient, they are weaned from this reliance such that their processing reflects the interaction between syntactic and lexical processing that is characteristic of adult native speakers. When and if they do, we could say that their L2 processing is, both internally and externally, nativelike.
The declarative/procedural model and the shallow structure hypothesis
Authors: Ullman Michael T.
Published: January 2011

Clahsen and Felser (CF) have written a beautiful and important paper. I applaud their integrative empirical approach, and believe that their theoretical account is largely correct, if not in some of its specific claims, at least in its broader assumptions. CF directly compare their shallow structure hypothesis (SSH) with a model that my colleagues and I have proposed for aspects of the neurocognition of first and second language: the “declarative/procedural” (DP) model. Although some of CF's discussion accurately depicts the DP model and its relation to the data, they also make a few critical errors.Here, I first summarize the DP model in both first language (L1) and adult-learned second language (L2), in order to be able to contrast it with the SSH, and then address the relevant problems in CF. For further details on the DP model and L1, see Ullman (2001a, 2001c, 2004) and Ullman et al. (1997). For the model as it applies to L2, see Ullman (2001b, 2005).
Correlates of limitations in activities of daily living and mobility among community-dwelling older Singaporeans
Authors: CHAN ANGELIQUE , MALHOTRA CHETNA , ØSTBYE TRULS
Published: January 2011

Most research on activity limitations has focused on the association between chronic health conditions and activity limitations and given little attention to their social and financial implications. In this paper, we study the correlates of limitations in the activities of daily living (ADL) and mobility among older Singaporeans (aged 55 or more years), based on the ‘disability frameworks’ or pathways proposed by Nagi, Verbrugge and the International Classification of Functioning, Disability and Health. Data from the 2005 National Survey of Senior Citizens in Singapore was used. The weighted prevalence of ADL and mobility limitations was calculated, overall and in subgroups. Logistic regression models were used to assess predictors of ADL and mobility limitations and variation in involvement with family, society, work, use of services and perceived financial adequacy, by ADL and mobility status was studied. We found the overall weighted prevalence of ADL and mobility limitation to be 5 and 8 per cent, respectively. Significant risk factors for ADL and mobility limitation were being older (aged 75 or more years), widowed, having diabetes, joint/bone problems, stroke, cancer and low income. Individuals with ADL and mobility limitations had lower involvement with family, society and work, and perceived financial adequacy, while use of services was higher. The findings underline the importance of improving elderly services for sustained integration of disabled elderly within the community.
Women, Missions and Modernity: From Anti-Slavery to Missionary Zeal, 1780s to 1840s
Authors: Dimock Elizabeth
Published: January 2011

This paper focuses on women and the early period of the modern missionary movement from the late eighteenth century to the 1830s, considering links between the anti-slavery campaigns and the development of overseas missions within a framework of early twenty-first century understandings of modernity. There are three sections. The first discusses women's writing in relation to anti-slavery, the second examines the shift from women's anti-slavery activism at home to broader activities at home and overseas, while the third focuses on the London-based Female Education Society and its role as an organising body for women in educational work overseas. Connecting the three sections is an understanding of women's lives in a changing world, caught up in Britain's expanding empire. The women described here were mostly from Christian families in a time when religious affiliation was in a state of flux. This paper argues that women's interest in anti-slavery became enmeshed with a desire to bring education to those who would attain freedom and was encompassed in broader understandings of liberty and enlightenment. The desire to educate expanded to include the “heathen” in many parts of the world, and this paralleled the burgeoning of modern missions.
“To Save the Women of China from Fear, Opium and Bound Feet”: Australian Women Missionaries in Early Twentieth-Century China
Authors: Paddle Sarah
Published: January 2011

This article explores the experiences of Western women missionaries in a faith mission and their relationships with the women and children of China in the early years of the twentieth century. In a period of twenty years of unprecedented social and political revolution missionaries were forced to reconceptualise their work against a changing discourse of Chinese womanhood. In this context, emerging models of the Chinese New Woman and the New Girl challenged older mission constructions of gender. The Chinese reformation also provided missionaries with troubling reflections on their own roles as independent young women, against debates about modern women at home, and the emerging rights of white women as newly enfranchised citizens in the new nation of Australia.
Isawa Shūji's “National Music”: National Sentiment and Cultural Westernisation in Meiji Japan
Authors: Toru Takenaka
Published: January 2011

Japan's opening up in the mid-1850s and the ensuing spread of Western influence caused a fundamental dislocation in the country's socio-cultural life. Values and habits were rocked to their core after centuries of isolation, and people were quite helpless for how to come to terms with this rapid influx of foreign things. Faced with abrupt and severe changes, they felt deeply disoriented and their self-awareness was considerably shaken. This soon led to differentiation in attitudes toward the Western challenge. Some insisted that people should reconstruct their identity just by adjusting to Western standards. Modernisation was the only choice in their eyes and they believed that Japan should make efforts to adopt Western ways into every aspect of the nation's life. Customs and manners had to be reexamined based on this new criteria and reformed accordingly or, if this was ever impossible, abolished. Others, however, saw in it nothing more than shameful mimicry. They believed that the nation's self-confidence would be lost if people were absorbed in Westernisation. Instead they thought that Japan's cultural backbone should build on the country's long-standing rich traditions, rather than being dazzled by the superficial affluence of Western civilisation.
Equality in the theory of international society: Kelsen, Rawls and the English School
Authors: HJORTH RONNIE
Published: January 2011

This article examines the idea of equality in the theory of international society. Contrary to the widespread contemporary notion of equality as a corollary principle to sovereignty, the central argument of the article is that equality and sovereignty can and ought to be disconnected, and that the concept of equality, when uncoupled from sovereignty, is a better point of departure when theorising international society than is, for example, non-intervention or sovereignty. An alternative approach to deal with equality of states and other entities within international society is sketched out.
The Allied punishment and attempted socialisation of the Bolsheviks (1917–1924): An English School approach
Authors: CANTIR CRISTIAN
Published: January 2011

This article makes theoretical and empirical contributions to the recent literature on the socialisation and punishment of state and non-state actors. First, it argues that the English School can add significantly to our understanding of the socialisation and punishment processes because of the theory's emphasis on great powers as ‘custodians’ of the society of states. Second, it analyses the policies of the United Kingdom, France, and, to a lesser degree, a number of other powers toward the Bolsheviks and the Whites during the Civil War and beyond (1917–1924). The basic argument is that London, Paris, and other capitals acted like ‘guardians’ of the society of states in their attempt to punish and socialise the participants in the Civil War.
Density diagnostic of highly ionized samarium laser produced plasma using Ni-like spatially resolved spectra
Authors: Louzon E. , Henis Z. , Levy I. , Hurvitz G. , Ehrlich Y. , Frankel M. , Maman S. , Raicher E. , Malka A. , Mandelbaum P. , Zigler A.
Published: January 2011

Detailed spectroscopic identification and analysis of lines emitted by Ni-like ions may infer on plasma parameters, such as electron density, temperature, and ionization state. Spatially, resolved X-ray spectra of samarium laser produced plasma were recorded in the 7 to10 Å wavelength range. Measured line intensity ratios of Ni-like 3d-5f, 3p-4d, 3p-4s, and 3s-4p transitions were used for electron density diagnostic as a function of the distance from the target. Calculations using Hebrew University Lawrence Livermore Atomic Code show that these ratios are not very sensitive to the electron temperature in the range from 500 to 1000 eV. Self-absorption of some lines is found to be important at electron densities higher than 1021cm−3. The inferred ranges of electron density and temperature are found to be consistent with results of hydrodynamic simulations and models of ionization in plasma.
Solving stiffness and deformation of a 3-UPU parallel manipulator with one translation and two rotations
Authors: Hu Bo , Lu Yi
Published: January 2011

The stiffness modeling and elastic deformation of 3 degrees of freedom, 3-universal joints–prismatic pairs–universal joints (UPU) parallel manipulator (PM) with one translation and two rotations are studied. First, the constraint wrenches are derived corresponding to the special orientation of universal joints in each of the UPU legs. Second, the elastic deformation of active legs produced by these active forces and constrained wrenches are derived. Third, a 6 × 6 Jacobian matrix is derived from constraint and active forces, and the statics is solved. Finally, the stiffness matrix of 3-UPU PM is established and its elastic deformation is solved.
Assessing spatiotemporal patterns of multidrug-resistant and drug-sensitive tuberculosis in a South American setting
Authors: LIN H. , SHIN S. , BLAYA J. A. , ZHANG Z. , CEGIELSKI P. , CONTRERAS C. , ASENCIOS L. , BONILLA C. , BAYONA J. , PACIOREK C. J. , COHEN T.
Published: January 2011

We examined the spatiotemporal distribution of laboratory-confirmed multidrug-resistant tuberculosis (MDR TB) cases and that of other TB cases in Lima, Peru with the aim of identifying mechanisms responsible for the rise of MDR TB in an urban setting. All incident cases of TB in two districts of Lima, Peru during 2005–2007 were included. The spatiotemporal distributions of MDR cases and other TB cases were compared with Ripley'sKstatistic. Of 11 711 notified cases, 1187 received drug susceptibility testing and 376 were found to be MDR. Spatial aggregation of patients with confirmed MDR disease appeared similar to that of other patients in 2005 and 2006; however, in 2007, cases with confirmed MDR disease were found to be more tightly grouped. Subgroup analysis suggests the appearance of resistance may be driven by increased transmission. Interventions should aim to reduce the infectious duration for those with drug-resistant disease and improve infection control.
Explicit characterization of the polarization tensor for rough thin layers
Authors: POIGNARD C.
Published: January 2011

In the paper ‘Approximate transmission conditions through a rough thin layer. The case of periodic roughness’ (Eur. J. Appl. Math. 2010; 21: 51–75), Ciuperca et al. derive transmission conditions that are equivalent to a rough thin layer for the conductivity problem. These conditions involved a pair of vector fields (A0, a0) and two constants D1 and D2 that are given implicitly by solving a partial differential equation in the infinite strip × /2π. We give here an explicit expression of a0 in terms of A0, which shows that D1 equals zero. We infer an explicit characterization of the polarization tensor as given by Capdeboscq and Vogelius (ESAIM:M2AN. 2003; 37: 159–173).
On the breakup of air bubbles in a Hele-Shaw cell
Authors: ENTOV VLADIMIR , ETINGOF PAVEL
Published: January 2011

We study the problem of breakup of an air bubble in a Hele-Shaw cell. In particular, we propose some sufficient conditions of breakup of the bubble, and ways to find the contraction points of its parts. We also study regulated contraction of a pair of bubbles (in which the rates of air extraction from the bubbles are controlled) and study various asymptotic questions (such as the asymptotics of contraction of a bubble to a degenerate critical point, and asymptotics of contraction of a small bubble in the presence of a big bubble)
Building a consensus: A rectangle covering problem
Authors: BIRD RICHARD S.
Published: January 2011

The other day, over a very pleasant lunch in the restaurant of Oxford's recently renovated Ashmolean Museum, Oege de Moor gave me a problem about rectangles. The problem is explained more fully later, but roughly speaking one is given a finite set of rectangles RS and a rectangle R completely covered by RS. The task is to construct a single rectangle covering R among the elements of a larger set of rectangles associated with RS, called the saturation of RS. The saturation of RS is the closure of RS under so-called consensus operations, a term coined in (Quine, 1959), in which two rectangles are combined in two distinct ways to form new rectangles. The rectangle problem is a simplified version of containment-checking, a crucial component in a type inference algorithm for Datalog programs (Schäfer & de Moor, 2010). 19 In the Schäfer-de Moor algorithm the problem is generalised to cubes in n-space rather than rectangles in two-space, the components of each cube are given by propositional formulae rather than by intervals on the real line, and certain equality and inhabitation constraints are taken into account. Oege felt that the central proof, Lemma 15 in (Schäfer & de Moor, 2010), deserved to be simplified so he posed the rectangle problem as a special case. This pearl was composed in response to the challenge.
On the effectiveness of Robot-Assisted Language Learning
Authors: Lee Sungjin , Noh Hyungjong , Lee Jonghoon , Lee Kyusong , Lee Gary Geunbae , Sagong Seongdae , Kim Munsang
Published: January 2011

This study introduces the educational assistant robots that we developed for foreign language learning and explores the effectiveness of robot-assisted language learning (RALL) which is in its early stages. To achieve this purpose, a course was designed in which students have meaningful interactions with intelligent robots in an immersive environment. A total of 24 elementary students, ranging in age from ten to twelve, were enrolled in English lessons. A pre-test/post-test design was used to investigate the cognitive effects of the RALL approach on the students’ oral skills. No significant difference in the listening skill was found, but the speaking skills improved with a large effect size at the significance level of 0.01. Descriptive statistics and the pre-test/post-test design were used to investigate the affective effects of RALL approach. The result showed that RALL promoted and improved students’ satisfaction, interest, confidence, and motivation at the significance level of 0.01.
The ageing immune system and its clinical implications
Authors: Wordsworth DTHJ , Dunn-Walters DK
Published: January 2011

Ageing is associated with multiple changes in many different components of the immune system. A healthy immune system exists in a state of balance between efficient effector responses against pathogens and tolerance to self antigens. This balance is changed with age; functions such as antigen recognition, phagocytosis, antigen presentation, chemotaxis, cytokine secretion and killing ability are all compromised. Aberrant cellular responses lead to an altered cytokine network with increases in inflammatory cytokines and decreases in anti-inflammatory cytokines leading to a pro-inflammatory state. Consequently older patients require extra care in diagnosis of infections as symptoms may be perturbed, resulting in unusual presentations of common conditions. The defects in immunity due to immunosenescence also mean that older patients require more care and screening than other patients in the same disease cohort. Though it is generally understood by clinicians that older patients are more at risk from multiple infections, the wider clinical effects of immunosenescence are less understood. The immune system is involved in several neurodegenerative conditions and the inflammatory conditions of immunosenescence may be a key factor in pathogenesis. Similarly, there is reason to believe that immunosenescence might be a key factor explaining the increased incidence of cancer in older age. With increasing understanding of the immune system's involvement in many of these pathological processes, and the contribution that immunosenescence makes to these, more efficient vaccines and novel therapies may be developed to prevent/treat these conditions.
Carotid artery disease in older people: clinical features and management
Authors: Naylor A Ross
Published: January 2011

The ‘take home’ messages for managing elderly patients with symptomatic carotid disease are that they need to be investigated as soon as possible after onset of the index event and that someone has to take active responsibility for ensuring that risk factor control and best medical therapy is started as soon as possible. In this modern era, patients suffering a transient ischaemic attack/minor stroke should be seen in dedicated, rapidly accessible single visit clinics, and those found to have significant carotid disease should generally be admitted and undergo expedited carotid endarterectomy (CEA) unless contra-indicated. Every centre should now aim to be performing carotid surgery within 14 days of onset of symptoms, with this threshold likely to become even shorter in the future. The current culture of allowing delays to treatment should be considered unacceptable. Evidence suggests that the risk of procedural stroke is lower in higher volume centres and this should be considered when planning referrals. Recently symptomatic elderly patients deemed unfit for CEA should be considered for carotid artery stenting (CAS), but with the caveat that this may be associated with an increased risk of procedural stroke. In this situation, every patient should be considered on an individual basis and no symptomatic patient should be denied access to surgery simply on the grounds of age. Meta-analyses of data from the international trials have clearly shown that patients aged >75 years gain considerably more benefit from CEA than any other age group. In contrast, there is no compelling evidence that patients aged >75 years with asymptomatic carotid artery disease benefit from CEA or CAS. For this category of patients, risk factor control and best medical therapy should remain the first line of management.
What is resilience? A review and concept analysis
Authors: Windle Gill
Published: January 2011

The complexities of defining what appears to be the relatively simple concept of resilience are widely recognized. This paper analyses the concept of resilience from a range of disciplinary perspectives and clarifies a definition in order to inform research, policy and practice. The work takes a life course approach to resilience, examining evidence derived from research across the lifespan. It incorporates the methods of systematic review, concept analysis and consultation through face-to-face meetings. The synthesis of methodological approaches enables a clear identification of the antecedents, defining attributes and consequences of resilience, validated with stakeholder partners. Through this process, resilience is defined as the process of effectively negotiating, adapting to, or managing significant sources of stress or trauma. Assets and resources within the individual, their life and environment facilitate this capacity for adaptation and ‘bouncing back’ in the face of adversity. Across the life course, the experience of resilience will vary. A large proportion of resilience research is routed within the discipline of developmental psychology, and has mainly been developed with children and adolescents. A major contribution to resilience research could be made through more multi-disciplinary studies that examine the dynamics of resilience across the lifespan, its role in healthy ageing and in managing loss, such as changes in cognitive functioning.
Local Resilience and Hamiltonicity Maker–Breaker Games in Random Regular Graphs
Authors: BEN-SHIMON SONNY , KRIVELEVICH MICHAEL , SUDAKOV BENNY
Published: January 2011

For an increasing monotone graph propertythelocal resilienceof a graphGwith respect tois the minimalrfor which there exists a subgraphH⊆Gwith all degrees at mostr, such that the removal of the edges ofHfromGcreates a graph that does not possess. This notion, which was implicitly studied for somead hocproperties, was recently treated in a more systematic way in a paper by Sudakov and Vu. Most research conducted with respect to this distance notion focused on the binomial random graph model(n, p) and some families of pseudo-random graphs with respect to several graph properties, such as containing a perfect matching and being Hamiltonian, to name a few. In this paper we continue to explore the local resilience notion, but turn our attention to random and pseudo-randomregulargraphs of constant degree. We investigate the local resilience of the typical randomd-regular graph with respect to edge and vertex connectivity, containing a perfect matching, and being Hamiltonian. In particular, we prove that for every positive ϵ and large enough values ofd, with high probability, the local resilience of the randomd-regular graph,n, d, with respect to being Hamiltonian, is at least (1−ϵ)d/6. We also prove that for the binomial random graph model(n, p), for every positive ϵ > 0 and large enough values ofK, ifp>$\frac{K\ln n}{n}$then, with high probability, the local resilience of(n, p) with respect to being Hamiltonian is at least (1−ϵ)np/6. Finally, we apply similar techniques to positional games, and prove that ifdis large enough then, with high probability, a typical randomd-regular graphGis such that, in the unbiased Maker–Breaker game played on the edges ofG, Maker has a winning strategy to create a Hamilton cycle.
Accelerated modification of the zona pellucida is the primary cause of decreased fertilizability of oocytes in the 129 inbred mouse strain
Authors: Hino Toshiaki , Oda Kanako , Nakamura Kenji , Tateno Hiroyuki , Toyoda Yutaka , Yokoyama Minesuke
Published: January 2011

We investigated whether the small litter size in the 129 inbred mouse strain results from a reduction in oocyte fertilizability. Sensitivity of the zona pellucida to α-chymotrypsin was examined for oocytes collected at 14 h (shortly after ovulation), 17 h, and 20 h after hCG injection. Passage of spermatozoa through the zona pellucida (using anin vitrofertilization (IVF) technique) and the density of cortical granules were examined for oocytes collected at 14 and 17 h after hCG injection. The capability of the oolemma to fuse with the sperm plasma membrane was also evaluated by IVF using zona-free eggs. The zona pellucida became markedly resistant to the enzyme 17 h after hCG injection. IVF rates significantly decreased at this time. In addition, there was a significant reduction in the density of cortical granules. When zona-free oocytes were inseminated, high fertilization rates were obtained at both 17 and 14 h after hCG injection. These results indicate that accelerated modification of the zona pellucida primarily causes a decreased fertilizability of oocytes in 129 mice, resulting in the low reproductive performance of this strain.
Equine bone marrow mesenchymal or amniotic epithelial stem cells as feeder in a model for thein vitroculture of bovine embryos
Authors: Lange-Consiglio Anna , Maggio Valentina , Pellegrino Laura , Cremonesi Fausto
Published: January 2011

Various studies have shown that thein vitroculture environment is one of the key determinants of the blastocyst output. In the present study we investigated the effects of co-culturing bovine embryos with equine bone marrow mesenchymal stem cells (BM-MSCs) or equine amniotic epithelial stem cells (AE-SCs) onin vitroblastocysts development. BM specimens were obtained aseptically from sternal aspirates of horses under local anaesthesia and the isolated cells were resuspended in Dulbecco Modified Earle's Medium supplemented with 10 ng/ml of basic fibroblast growth factor (bFGF). Amniotic membranes were obtained from fresh placentas and, to release the AE cells, amniotic fragments were incubated with 0.05% trypsin for 45 min. Separated AE cells were plated in standard culture medium containing 10 ng/ml epidermal growth factor (EGF). Seven hundred and five cumulus–oocyte complexes were used and, after IVM and IVF, cumulus-free presumptive zygotes were randomly transferred into one of three co-culture systems in which they were cultured up to day 7: (1) co-culture with cumulus cells (control); (2) co-culture with BM-MSCs; and (3) co-culture with AE-SCs. Statistical analyses were performed by ANOVA. Blastocyst developmental rates were significantly different (p< 0.001) between control, AE-SCs and BM-MSCs (respectively 35.45, 41.84 and 30.09%). In conclusion, the AE-SC monolayer create a more suitable microenvironment necessary for inducing local cell activation and proliferation of the growing embryos in comparison with BM-MSCs and cumulus cells. It can be suggested that these cells secrete biologically active substances, including signalling molecules and growth factors of epithelial nature, different to those of the BM cells of mesenchymal origin.
Expression of follicle-stimulating hormone receptor (FSHR) in goat ovarian follicles and the impact of sequential culture medium on in vitro development of caprine preantral follicles
Authors: Saraiva M.V.A. , Celestino J.J.H. , Araújo V.R. , Chaves R.N. , Almeida A.P. , Lima-Verde I.B. , Duarte A.B.G. , Silva G.M. , Martins F.S. , Bruno J.B. , Matos M.H.T. , Campello C.C. , Silva J.R.V. , Figueiredo J.R.
Published: January 2011

This study evaluated the expression of FSH receptors (FSHR) in the different stages of goat follicle development and investigated whether the addition of increasing concentrations of FSH throughout the culture period influences the survival, growth and antral formation of in vitro-cultured caprine preantral follicles. The expression of FSHR was analysed before and after culturing follicles using real-time RT-PCR. For the culture, preantral follicles (≥150 μm) were isolated from ovarian fragments and cultured for 18 days in α-MEM+ alone or associated with recombinant FSH (rFSH: 100 or 1000 ng/ml), or in α-MEM+ supplemented with increasing concentrations of FSH throughout culture periods as follows: (a) sequential medium 1: FSH 100 ng/ml (from day 0 to 6), FSH 500 ng/ml (from day 6 to 12) and FSH 1000 ng/ml (from day 12 to 18); and (b) sequential medium 2: FSH 500 ng/ml (from day 0 to 9) and 1000 ng/ml (from day 9 to 18). Follicle development was evaluated on the basis of antral cavity formation, follicular and oocyte growth, and cumulus–oocyte complex health. The expression of FSHR in isolated caprine follicles increased from the preantral to antral phase. Regarding the culture, after 18 days, sequential medium 1 promoted follicular survival, antrum formation and a reduction in oocyte extrusion. Both sequential media promoted a higher rate of meiotic resumption compared with the other treatments. In conclusion, the addition of increased concentrations of FSH (sequential medium) has a significant impact on the in vitro development of caprine preantral follicles.
LEFTY2 expression and localization in rat oviduct during early pregnancy
Authors: Argañaraz Martin Eduardo , Apichela Silvana Andrea , Miceli Dora Cristina
Published: January 2011

In mammals, fertilization and preimplantation embryo development occurs in the oviduct. Cross-talk between the developing embryos and the maternal reproductive tract has been described in such a way as to show that the embryos modulate the physiology and gene expression of the oviduct. Different studies have indicated that transforming growth factor beta (TGF-β) can modulate the oviductal microenvironment and act as an autocrine/paracrine factor on embryo development. LEFTY2, a novel member of the TGF-β superfamily is involved in the negative regulation of other cytokines in this family such as nodal, activin, BMPs, TGF-β1 and Vg1. In previous studies, we have reported that LEFTY2 is differentially expressed in the rat oviduct during pregnancy. In this study, we describe the temporal pattern of LEFTY2 in pregnant and non-pregnant rat oviduct by western blotting, which showed higher levels of LEFTY2 on day 4 of pregnancy, a time at which the embryos are ending their journey along the oviduct. The cellular location of LEFTY2 was assessed by immunohistochemistry, which showed immunolabelling in the cytoplasm and at the apical surface of the oviductal epithelial cells. The oviductal fluid also presented a 26 kDa band, which corresponds to the biologically active form of this protein, at the preimplantation period of pregnancy, indicating LEFTY2 secretion to the lumen. As LEFTY2 is expressed at a high level just before the embryos pass to the uterus, its biological effect might be relevant and significant for the preimplantation stage of embryo development in the oviduct. The fact that embryos do not express LEFTY2 at this stage of development supports this hypothesis.
Congenital tricuspid regurgitation: review and a proposed new classification
Authors: Gupta Anubhav , Grover Vijay , Gupta Vijay K.
Published: January 2011

Background and aim

Congenital tricuspid regurgitation is an extremely rare condition. The morphologic heterogeneity makes it difficult to derive any conclusions regarding the best strategy for management of this condition.

Methods

We analysed the published literature on “congenital tricuspid regurgitation” using MEDLINE. In addition, the reference sections of all relevant articles were searched to identify additional cases. Studies published till June 2009 are included.

Results

As far as we could establish, there were 123 cases of congenital tricuspid regurgitation. Of these, 63 were documented during surgery, 38 during autopsy, and 22 were diagnosed by echocardiography or cardiac catheterisation. The mean age was 22.57 years, with a standard deviation of 23.42 years, and the age ranged from 1 day to 80 years, with a median of 16 years. There was a male predominance, with a male-to-female ratio of approximately 3:2.

Conclusion

Congenital tricuspid regurgitation is an uncommon clinical entity with wide anatomical variations. The severity of disease dictates the presentation in infancy, childhood, or adulthood. Tricuspid valve repair is the ideal treatment whenever feasible, especially in children. We propose a new classification for congenital tricuspid regurgitation, which not only includes the anatomical variations, but can also help the surgeon in deciding on the best strategy for management.
Sudden death in a patient with Noonan syndrome
Authors: Aydin Alper , Yilmazer Mustafa S. , Gurol Tayfun
Published: January 2011

We report here the case of a 27-year-old woman with Noonan syndrome presenting with ventricular fibrillation. After successful defibrillation, echocardiography revealed hypertrophic cardiomyopathy associated with left ventricular outflow tract obstruction. Normal echocardiographic cardiac structure and function were reported 11 years ago. This case emphasises the importance of regular follow-up in patients with congenital disorders in which cardiac manifestations might develop in early adulthood or later.