bluuebunny/crossref_metadata_2025 huggingface dataset:
Modeling and Security in Cloud Ecosystems
Authors: Fernandez Eduardo , Yoshioka Nobukazu , Washizaki Hironori , Syed Madiha
Published: April 2016

Clouds do not work in isolation but interact with other clouds and with a variety of systems either developed by the same provider or by external entities with the purpose to interact with them; forming then an ecosystem. A software ecosystem is a collection of software systems that have been developed to coexist and evolve together. The stakeholders of such a system need a variety of models to give them a perspective of the possibilities of the system, to evaluate specific quality attributes, and to extend the system. A powerful representation when building or using software ecosystems is the use of architectural models, which describe the structural aspects of such a system. These models have value for security and compliance, are useful to build new systems, can be used to define service contracts, find where quality factors can be monitored, and to plan further expansion. We have described a cloud ecosystem in the form of a pattern diagram where its components are patterns and reference architectures. A pattern is an encapsulated solution to a recurrent problem. We have recently expanded these models to cover fog systems and containers. Fog Computing is a highly-virtualized platform that provides compute, storage, and networking services between end devices and Cloud Computing Data Centers; a Software Container provides an execution environment for applications sharing a host operating system, binaries, and libraries with other containers. We intend to use this architecture to answer a variety of questions about the security of this system as well as a reference to design interacting combinations of heterogeneous components. We defined a metamodel to relate security concepts which is being expanded.
NAFLD and Increased Aortic Stiffness: Parallel or Common Physiopathological Mechanisms?
Authors: Villela-Nogueira Cristiane , Leite Nathalie , Cardoso Claudia , Salles Gil
Published: April 2016

Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver diseases worldwide. Liver inflammation and fibrosis related to NAFLD contribute to disease progression and increasing liver-related mortality and morbidity. Increasing data suggest that NAFLD may be linked to atherosclerotic vascular disease independent of other established cardiovascular risk factors. Central arterial stiffness has been recognized as a measure of cumulative cardiovascular risk marker load, and the measure of carotid-femoral pulse wave velocity (cf-PWV) is regarded as the gold standard assessment of aortic stiffness. It has been shown that increased aortic stiffness predicts cardiovascular morbidity and mortality in several clinical settings, including type 2 diabetes mellitus, a well-known condition associated with advanced stages of NAFLD. Furthermore, recently-published studies reported a strong association between NAFLD and increased arterial stiffness, suggesting a possible link in the pathogenesis of atherosclerosis and NAFLD. We sought to review the published data on the associations between NAFLD and aortic stiffness, in order to better understand the interplay between these two conditions and identify possible common physiopathological mechanisms.
Is It Reliable to Use Common Molecular Docking Methods for Comparing the Binding Affinities of Enantiomer Pairs for Their Protein Target?
Authors: Ramírez David , Caballero Julio
Published: April 2016

Molecular docking is a computational chemistry method which has become essential for the rational drug design process. In this context, it has had great impact as a successful tool for the study of ligand–receptor interaction modes, and for the exploration of large chemical datasets through virtual screening experiments. Despite their unquestionable merits, docking methods are not reliable for predicting binding energies due to the simple scoring functions they use. However, comparisons between two or three complexes using the predicted binding energies as a criterion are commonly found in the literature. In the present work we tested how wise is it to trust the docking energies when two complexes between a target protein and enantiomer pairs are compared. For this purpose, a ligand library composed by 141 enantiomeric pairs was used, including compounds with biological activities reported against seven protein targets. Docking results using the software Glide (considering extra precision (XP), standard precision (SP), and high-throughput virtual screening (HTVS) modes) and AutoDock Vina were compared with the reported biological activities using a classification scheme. Our test failed for all modes and targets, demonstrating that an accurate prediction when binding energies of enantiomers are compared using docking may be due to chance. We also compared pairs of compounds with different molecular weights and found the same results.
Exogenous R-Spondin1 Induces Precocious Telogen-to-Anagen Transition in Mouse Hair Follicles
Authors: Li Na , Liu Shu , Zhang Hui-Shan , Deng Zhi-Li , Zhao Hua-Shan , Zhao Qian , Lei Xiao-Hua , Ning Li-Na , Cao Yu-Jing , Wang Hai-Bin , Liu Shuang , Duan En-Kui
Published: April 2016

R-spondin proteins are novel Wnt/β-catenin agonists, which signal through their receptors leucine-rich repeat-containing G-protein coupled receptor (LGR) 4/5/6 and substantially enhance Wnt/β-catenin activity. R-spondins are reported to function in embryonic development. They also play important roles in stem cell functions in adult tissues, such as the intestine and mammary glands, which largely rely on Wnt/β-catenin signaling. However, in the skin epithelium and hair follicles, the information about R-spondins is deficient, although the expressions and functions of their receptors, LGR4/5/6, have already been studied in detail. In the present study, highly-enriched expression of the R-spondin family genes (Rspo1/2/3/4) in the hair follicle dermal papilla is revealed. Expression of Rspo1 in the dermal papilla is specifically and prominently upregulated before anagen entry, and exogenous recombinant R-spondin1 protein injection in mid-telogen leads to precocious anagen entry. Moreover, R-spondin1 activates Wnt/β-catenin signaling in cultured bulge stem cells in vitro, changing their fate determination without altering the cell proliferation. Our pioneering study uncovers a role of R-spondin1 in the activation of cultured hair follicle stem cells and the regulation of hair cycle progression, shedding new light on the governance of Wnt/β-catenin signaling in skin biology and providing helpful clues for future treatment of hair follicle disorders.
Temperature-Driven Structural and Morphological Evolution of Zinc Oxide Nano-Coalesced Microstructures and Its Defect-Related Photoluminescence Properties
Authors: Lim Karkeng , Abdul Hamid Muhammad , Shamsudin Roslinda , Al-Hardan N.H. , Mansor Ishak , Chiu Weesiong
Published: April 2016

In this paper, we address the synthesis of nano-coalesced microstructured zinc oxide thin films via a simple thermal evaporation process. The role of synthesis temperature on the structural, morphological, and optical properties of the prepared zinc oxide samples was deeply investigated. The obtained photoluminescence and X-ray photoelectron spectroscopy outcomes will be used to discuss the surface structure defects of the prepared samples. The results indicated that the prepared samples are polycrystalline in nature, and the sample prepared at 700 °C revealed a tremendously c-axis oriented zinc oxide. The temperature-driven morphological evolution of the zinc oxide nano-coalesced microstructures was perceived, resulting in transformation of quasi-mountain chain-like to pyramidal textured zinc oxide with increasing the synthesis temperature. The results also impart that the sample prepared at 500 °C shows a higher percentage of the zinc interstitial and oxygen vacancies. Furthermore, the intensity of the photoluminescence emission in the ultraviolet region was enhanced as the heating temperature increased from 500 °C to 700 °C. Lastly, the growth mechanism of the zinc oxide nano-coalesced microstructures is discussed according to the reaction conditions.
Droplet Velocity in an Electrowetting on Dielectric Digital Microfluidic Device
Authors: Nahar Mun , Nikapitiya Jagath , You Seung , Moon Hyejin
Published: April 2016

In many electrowetting on dielectric (EWOD) based microfluidics devices, droplet actuation speed is a crucial performance-controlling parameter. Our present study aims to characterize and study droplet speed in a typical EWOD device. First, a practical droplet speed measurement method has been methodically demonstrated and some related velocity terms have been introduced. Next, influence of electrode shape on droplet speed has been studied and a new design to enhance droplet speed has been proposed and experimentally demonstrated. Instead of using square shaped electrodes, rectangular electrodes with smaller widths are used to actuate droplets. Additionally, different schemes of activating electrodes are studied and compared for the same applied voltage. The experiments show that a particular scheme of activating the array of rectangular electrodes enhances the droplet speed up to 100% in comparison to the droplet speed in a conventional device with square shaped electrodes.
Welcome to MTI—A New Open Access Journal Dealing with Blue Sky Research and Future Trends in Multimodal Technologies and Interaction
Authors: Cheok Adrian , Portalés Ricart Cristina
Published: April 2016

In this era of massive use of computers and other computational devices (e.g., low-cost wearable sensors, smartphones, other smart devices, etc.), the nature of digital data is becoming more complex and heterogeneous.
A Combined Satellite-Derived Drought Indicator to Support Humanitarian Aid Organizations
Authors: Enenkel Markus , Steiner Caroline , Mistelbauer Thomas , Dorigo Wouter , Wagner Wolfgang , See Linda , Atzberger Clement , Schneider Stefan , Rogenhofer Edith
Published: April 2016

Governments, aid organizations and researchers are struggling with the complexity of detecting and monitoring drought events, which leads to weaknesses regarding the translation of early warnings into action. Embedded in an advanced decision-support framework for Doctors without Borders (Médecins sans Frontières), this study focuses on identifying the added-value of combining different satellite-derived datasets for drought monitoring and forecasting in Ethiopia. The core of the study is the improvement of an existing drought index via methodical adaptations and the integration of various satellite-derived datasets. The resulting Enhanced Combined Drought Index (ECDI) links four input datasets (rainfall, soil moisture, land surface temperature and vegetation status). The respective weight of each input dataset is calculated for every grid point at a spatial resolution of 0.25 degrees (roughly 28 kilometers). In the case of data gaps in one input dataset, the weights are automatically redistributed to other available variables. Ranking the years 1992 to 2014 according to the ECDI-based warning levels allows for the identification of all large-scale drought events in Ethiopia. Our results also indicate a good match between the ECDI-based drought warning levels and reported drought impacts for both the start and the end of the season.
Sensor Stability for SST (3S): Toward Improved Long-Term Characterization of AVHRR Thermal Bands
Authors: He Kai , Ignatov Alexander , Kihai Yury , Cao Changyong , Stroup John
Published: April 2016

Recently, the National Oceanic and Atmospheric Administration (NOAA) performed sea surface temperature (SST) reanalysis (RAN1) from seven AVHRR/3s onboard NOAA-15 to -19 and Metop-A and -B, from 2002–present. Operational L1b data were used as input. The time series of clear-sky ocean brightness temperatures (BTs) and derived SSTs were found to be unstable. The SSTs were empirically stabilized against in situ SSTs using a 90-day moving filter, while the measured BTs were left intact. However, some users are interested in direct radiance assimilation and need stable BTs. Additionally, stabilized BTs will greatly benefit SST (by minimizing the need for their empirical stabilization), and other Level 2 products derived from AVHRR. To better understand the AVHRR calibration and stabilize its BTs, the Sensor Stability for SST (3S; www.star.nesdis.noaa.gov/sod/sst/3s/) system was established at NOAA, which monitors orbital statistics of the sensor measured blackbody temperatures (BBTs), blackbody counts (BCs), and the space counts (SCs), along with the derived calibration gains and offsets. Analyses are performed separately for the satellite night (when the satellite is in the Earth’s shadow) and day (on the sunlit part of its orbit). Factors affecting the BBT, BC and SC are also monitored, including the Sun and Moon position relative to the sensor, local equator crossing time, and duration of the satellite night. All AVHRRs show long-term and band-specific smooth changes in the calibration gains and offsets, which are occasionally perturbed by spurious non-monotonic anomalies. The most prominent irregularities occur shortly after the satellite crosses from the night into day, or when it is in a (near) full Sun orbit for extended periods of time. We argue that the operational quality control (QC) and calibration procedures are suboptimal and should be improved. Analyses in 3S suggest that a more stringent QC is needed, and scan lines where the calibration coefficients cannot be derived, due to poor quality SC, BC or BBT data, should be filled in by interpolation from the best parts of orbit or more broadly satellite lifetime. Work is underway to redesign the AVHRR QC and calibration algorithms and create a more stable long-term record of AVHRR calibration and BTs, and use them in the subsequent SST RANs.
Risk Assessment in the Istanbul Strait Using Black Sea MOU Port State Control Inspections
Authors: Emecen Kara Esma
Published: April 2016

The Istanbul Strait has intense maritime traffic while, at the same time, it poses significant navigational challenges. Due to these properties, there is always a high risk arising from maritime shipping in this region. Especially, substandard ships threaten life, as well as the marine environment. In this aspect, Black Sea Memorandum of Understanding (MOU) Port State Control Inspections are important for maritime safety in the Istanbul Strait, because they directly reflect the performance of ships passing through the Istanbul Strait. Stringent and effective inspections assist in the enhancement of navigation safety and help to develop sustainable environment management. In this context, this study aims to assess maritime safety for the Strait region concerning passing flag states. Firstly, to assess the performance of flag states in general, the Black Sea MOU Black-Grey-White lists were generated for the period 2004–2014 and the change in the performance of these flags was examined. Secondly, the risk level of each flag state passing from the Strait region was determined using the method of weighted points based on the Black-Grey-White List, deficiency index level, casualty index level, and passing index level.
Dans le Sud-Ouest de Madagascar, la ville se fait plus proche mais la terre change de mains. (In Southwest Madagasacar, te city gets closer but land is changing hands)
Authors: Thibaud B.
Published: April 2016

Si l'intensification des liens entre la ville de Toliara et les campagnes alentours semble offrir de nouvelles opportunités de développement, les recompositions socio-spatiales qui en résultent sont en revanche porteuses de tensions foncières croissantes.
Optimal Dose of Vitamin D3 400 I.U. for Average Adults has A Significant Anti-Cancer Effect,While Widely Used 2000 I.U. or Higher Promotes Cancer: Marked Reduction of Taurine & 1α, 25(OH)2D3 Was Found In Various Cancer Tissues and Oral Intake
of Optimal Dose of Taurine 175mg for Average Adults, Rather Than 500mg, Was Found to Be A New Potentially Safe and More Effective Method of Cancer Treatment
Authors: Omura Yoshiaki , Lu Dominic , Jones Marilyn K. , Nihrane Abdallah , Duvvi Harsha , Yapor Dario , Shimotsuura Yasuhiro , Ohki Motomu
Published: April 2016

During the past 10 years, the author had found that the optimal dose of Vitamin D3 400 I.U. has safe & effective anticancer effects, while commonly used 2000∼5000 I.U. of Vit. D3 often creates a 2∼3 time increase in cancer markers. We examined the concentration
of Taurine in normal internal organs and in cancer using Bi-Digital O–Ring Test. We found that Taurine levels in normal tissue are 4∼6ng. But, the amount of Taurine of average normal value of 5.0∼5.25ng was strikingly reduced to 0.0025∼0.0028ng in this study of several examples
in adenocarcinomas of the esophagus, stomach, pancreas, colon, prostate, and lung, as well as breast cancer. The lowest Taurine levels of 0.0002∼0.0005ng were found in so called Zika virus infected babies from Brazil with microcephaly. While Vitamin D3 receptor stimulant 1α,
25 (OH)2D3 in normal tissues was 0.45∼0.53ng, they were reduced to 0.0025∼0.006ng in cancers (1/100th∼1/200th of normal value), particularly in various adenocarcinomas. All of these adenocarcinomas had about 1500ng HPV–16 viral infection. In 500 breast
cancers, about 97% had HPV–16. The optimal dose of Taurine for average adult has been found to be about 175mg, rather than the widely used 500mg. In addition, since Taurine is markedly reduced to close to 1/1000th ∼ 1/2000th of its normal value in these cancer tissues, we examined
the effect of the optimal dose of Taurine on cancer patients. Optimal dose of Taurine produced a very significant decrease in cancer–associated parameters, such as Oncogene C–fosAb2 & Integrin α5β1 being reduced to less than 1/1,000th, and 8–OH–dG
(which increases in the presence of DNA mutation) reduced to less than 1/10th. The optimal dose of Taurine 175mg for average adult various cancer patient 3 times a day alone provide beneficial effects with very significant anti–cancer effects with strikingly increased urinary excretion
of bacteria, viruses, & funguses, asbestos, toxic metals & other toxic substances. However, optimal doses of Taurine combined with optimal individualized doses of ω3 fish oil [EPA 180mg & DHA 120mg] & special cilantro tablet 3 times/day without creating harmful drug interactions
among them including other essential drugs, is often extremely safe, more effective, economical & non–invasive new treatment for various cancer patients.
Assessing Festival Attendees' Behavioral Intentions Through Perceived Service Quality and Visitor Satisfaction
Authors: Hall Sophie , Oriade Ade , Robinson Peter
Published: April 2016

This study examines the festival attributes with the most significant impact on attendee quality perception, and subsequently the relationship between quality, satisfaction, and the likelihood that attendees would revisit and recommend the festival to others. Data were collected via self-completed questionnaires at Worcester city with particular focus on Worcester festival, which is an annual community festival staged for 2 weeks in the summer. Perceptions of attendees were analyzed and the findings support the view that festival attributes determine perceived quality and that quality has effect on satisfaction and behavioral intentions. This study contributes towards the understanding of festival attendee service quality perception, satisfaction, and subsequent behavioral intentions. The research implications were discussed and recommendations for future research and industry managers were made.
Examining the Role of Self-concept Theory on Motivation, Satisfaction, and Intent to Return of Music Festival Volunteers
Authors: Bachman Jarrett R. , Norman William C. , Hopkins Christopher D. , Brookover Robert S.
Published: April 2016

Volunteers play a critical role in the production of festivals and events in many ways, such as providing assistance to artists and vendors, direction for attendees, and grounds keeping. However, determining what motivates volunteers, how they become satisfied, and how likely they are
to continue volunteering at an event has been overlooked. This is especially true in reference to the music festival industry, which has seen unparalleled growth in the last decade. In order to further understand music festival volunteers, the concept of self-image was examined at the 2013
Austin City Limits Music Festival to determine linkages between self-image congruency and motivation, satisfaction, and intent to return using structural equation modeling. This music festival is of specific interest to the development of understanding the role of self-image in festivals and
events due to the scale and size of the festival as well as the festival's requirement of being a local resident in order to volunteer. As such, the importance of understanding these local volunteers at a mega-event, which hosts 75,000 attendees per day over two 3-day weekends, is vital. This
study found that self-image congruency has an impact on motivation, satisfaction, and intent to return and develops practical linkages and theoretical support for the consideration of self-image congruency when examining festival and event volunteers in a tourism context.
How Do You “do” Event Management Education (EME)? a Case Study of Event Management Higher Education Awards
Authors: Ryan W. Gerard
Published: April 2016

This case study of Event Management Education (EME) was conducted at the beginning of 2014. It presents the preliminary findings obtained from a questionnaire completed by EME lecturers and will contribute to the progress and direction of future EME awards. There is an indication from
these preliminary findings that while lecturers are confident of the quality of student they produce, they are aware difficulties exist in the teaching of EME. Also, while there is a desire from award leaders to modify EME awards, other influences from within the school may restrict these
objectives. Alongside these findings, there is good evidence of subject knowledge and industry experience from those who teach these awards.
A DEEP SEARCH FOR PROMPT RADIO EMISSION FROM THERMONUCLEAR SUPERNOVAE WITH THE VERY LARGE ARRAY
Authors: Chomiuk Laura , Soderberg Alicia M. , Chevalier Roger A. , Bruzewski Seth , Foley Ryan J. , Parrent Jerod , Strader Jay , Badenes Carles , Fransson Claes , Kamble Atish , Margutti Raffaella , Rupen Michael P. , Simon Joshua D.
Published: April 2016

Searches for circumstellar material around Type Ia supernovae (SNe Ia) are some of the most powerful tests of the nature of SN Ia progenitors, and radio observations provide a particularly sensitive probe of this material. Here, we report radio observations for SNe Ia and their lower-luminosity thermonuclear cousins. We present the largest, most sensitive, and spectroscopically diverse study of prompt (

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Prediction of Remission in a French Early Arthritis Cohort by RAPID3 and other Core Data Set Measures, but Not by the Absence of Rheumatoid Factor, Anticitrullinated Protein Antibodies, or Radiographic Erosions
Authors: Castrejón Isabel , Dougados Maxime , Combe Bernard , Fautrel Bruno , Guillemin Francis , Pincus Theodore
Published: April 2016

Objective.

To identify baseline variables that predict remission according to different criteria in rheumatoid arthritis (RA) in a comprehensive French ESPOIR early arthritis database.

Methods.

Individual variables and indices at baseline were analyzed in 664 patients for capacity to predict remission either 6 or 12 months later according to 4 criteria that require a formal joint count: the American College of Rheumatology/European League Against Rheumatism Boolean criteria, the Simplified Disease Activity Index, the Clinical Disease Activity Index, and the 28-joint Disease Activity Score; and 2 remission criteria that do not require a formal joint count: the Routine Assessment of Patient Index Data 3 (RAPID3) and the RAPID3 ≤ 3 + swollen joint, using univariate and multivariate logistic regressions.

Results.

Remission was predicted significantly 6 and/or 12 months later in 26.8%–51.4% of patients, according to all 6 criteria by younger age, low index scores, and better status for the 6/7 clinical RA core dataset measures: tender joint count, swollen joint count (SJC), physician’s global estimate, patient self-report Health Assessment Questionnaire (HAQ) physical function, pain, and patient’s global estimate. Remission was not predicted by the absence of “poor prognosis RA” indicators, rheumatoid factor (RF), anticitrullinated protein antibodies (ACPA), or radiographic erosions. In multivariate regressions that included only 3 variables, low HAQ function predicted remission by all criteria as effectively as SJC, erythrocyte sedimentation rate, or C-reactive protein.

Conclusion.

Younger age and 6 core dataset clinical measures, but not the absence of traditional “poor prognosis RA” indicators, RF, ACPA, or radiographic erosions, predicted remission according to 6 criteria, including 2 without a formal joint count.
The Incidence of Primary Systemic Vasculitis in Jerusalem: A 20-year Hospital-based Retrospective Study
Authors: Nesher Gideon , Ben-Chetrit Eli , Mazal Bracha , Breuer Gabriel S.
Published: April 2016

Objective.

The incidence of primary systemic vasculitides varies among different geographic regions and ethnic origins. The aim of this study was to examine the incidence rates of vasculitides in the Jerusalem Jewish population, and to examine possible trends in incidence rates over a 20-year period.

Methods.

The clinical databases of inpatients at the 2 medical centers in Jerusalem were searched for patients with vasculitis diagnosed between 1990–2009. Individual records were then reviewed by one of the authors. The significance of trends in incidence rates throughout the study period was evaluated by Pearson correlation coefficient.

Results.

The average annual incidence rate of polyarteritis nodosa was 3.6/million adults (95% CI 1.6–4.7). Incidence rates did not change significantly during this period (r = 0.39, p = 0.088). The incidence of granulomatosis with polyangiitis (GPA) was 4.1 (2.2–5.9) for the whole period, during which it increased significantly (r = 0.53, p < 0.05). The incidence of microscopic polyangiitis (MPA) was lower: 2.3 (1.2–3.5)/million. It also increased significantly (r = 0.55, p < 0.05). The incidence of eosinophilic granulomatosis with polyangiitis was 1.2 (0.4–1.9), which remained stable throughout the study period. The incidence of Takayasu arteritis was 2.1/million (95% CI 1.2–2.9), and it also remained stable. Giant cell arteritis (GCA) incidence was 8.1 (5.7–10.6)/100,000 population aged 50 years or older. In sharp contrast with other vasculitides, its incidence decreased significantly throughout the study period (r = −0.61, p < 0.01).

Conclusion.

The incidence rates of vasculitides in the Jewish population of Jerusalem are in the lower range of global incidence rates. While GPA and MPA incidence are increasing, GCA incidence is decreasing.
A Multifaceted Intervention to Improve Influenza, Pneumococcal, and Herpes Zoster Vaccination among Patients with Rheumatoid Arthritis
Authors: Baker David W. , Brown Tiffany , Lee Ji Young , Ozanich Amanda , Liss David T. , Sandler Diana S. , Ruderman Eric M.
Published: April 2016

Objective.

Vaccination rates for influenza, pneumococcus, and zoster in patients with rheumatoid arthritis (RA) have remained low. Simple electronic or paper reminders have produced only small increases in vaccination rates. We sought to identify a more effective approach to improve vaccination rates.

Methods.

We conducted a system-level intervention at an academic rheumatology clinic that included electronic reminders with linked order sets, physician auditing and feedback, patient outreach, and optional printed prescriptions for zoster vaccination at an outside pharmacy.

Results.

We targeted 1255 eligible patients with RA. There was no change in patients’ self-reported influenza vaccination rates, although the baseline self-reported rate was already high and much higher than that documented in the electronic health record. Pneumococcal vaccination rates increased from 28.7% to 45.8%; in regression analysis, the rate of change in pneumococcal vaccination increased by 9.4% per year above baseline trends (95% CI 3.9–15.5, p = 0.002). The rate of zoster vaccination increased from 2.5% to 4.5% overall (p = 0.01) and from 3.0% to 6.6% among patients not receiving biologic therapy that precluded zoster vaccination.

Conclusion.

Although the intervention improved pneumococcal and zoster vaccination rates, the improvement in pneumococcal vaccination rate was less than expected, and the zoster vaccination rate remained low even for ideal candidates. Likely barriers include lack of familiarity and difficulty using electronic reminders and order sets, uncertainty about the value and safety of recommended vaccines, and uncertainty about patients’ insurance coverage and prior vaccination history. Future interventions should include strategies to address these.
Predictors of Organ Damage Progression and Effect on Health-related Quality of Life in Systemic Lupus Erythematosus
Authors: Legge Alexandra , Doucette Steve , Hanly John G.
Published: April 2016

Objective.

To describe organ damage accrual, predictors of damage progression, and effect on health-related quality of life (HRQOL) in patients with systemic lupus erythematosus (SLE).

Methods.

A longitudinal database of patients who met the American College of Rheumatology (ACR) classification criteria for SLE was used. Annual assessments included the Systemic Lupus International Collaborating Clinics/ACR Damage Index (SDI) and the Medical Outcomes Study Short Form-36 (SF-36). The prognostic significance of demographic, disease-related, and treatment-related factors on damage progression was examined using multivariable Cox regression. The effect of changes in SDI scores on HRQOL, measured using the SF-36 summary and subscale scores, was assessed using linear mixed-effects modeling.

Results.

There were 273 patients with SLE studied over a mean (SD) duration of followup of 7.3 (4.3) years. During followup, 126 (46.2%) had an increase in SDI scores. Patients with preexisting damage at baseline were more likely to have earlier damage progression (HR 2.09, 95% CI 1.44–3.01). Older age, ≥ 8 ACR classification criteria, immunosuppressive drugs, cigarette smoking, and higher mean serum C-reactive protein levels were associated with an earlier increase in SDI scores in multivariable analysis. In general, changes in SDI scores were associated with initial declines in SF-36 scores at the time that damage occurred, with subsequent change comparable to that seen in patients without damage progression.

Conclusion.

This study identified multiple risk factors, some modifiable, associated with damage progression in patients with SLE. The negative effect on HRQOL emphasizes the need for treatment strategies to reduce the risk of organ damage over time.
Which Patients with Giant Cell Arteritis Will Develop Cardiovascular or Cerebrovascular Disease? A Clinical Practice Research Datalink Study
Authors: Robson Joanna C. , Kiran Amit , Maskell Joe , Hutchings Andrew , Arden Nigel , Dasgupta Bhaskar , Hamilton William , Emin Akan , Culliford David , Luqmani Raashid
Published: April 2016

Objective.

To evaluate the risk of cerebrovascular disease and cardiovascular disease (CVD) in patients with giant cell arteritis (GCA), and to identify predictors.

Methods.

The UK Clinical Practice Research Datalink 1991–2010 was used for a parallel cohort study of 5827 patients with GCA and 37,090 age-, sex-, and location-matched controls. A multivariable competing risk model (non-cerebrovascular/CV-related death as the competing risk) determined the relative risk [subhazard ratio (SHR)] between patients with GCA compared with background controls for cerebrovascular disease, CVD, or either. Each cohort (GCA and controls) was then analyzed individually using the same multivariable model, with age and sex now present, to identify predictors of CVD or cerebrovascular disease.

Results.

Patients with GCA, compared with controls, had an increased risk SHR (95% CI) of cerebrovascular disease (1.45, 1.31–1.60), CVD (1.49, 1.37–1.62), or either (1.47, 1.37–1.57). In the GCA cohort, predictors of “cerebrovascular disease or CVD” included increasing age, > 80 years versus < 65 years (1.98, 1.62–2.42), male sex (1.20, 1.05–1.38), and socioeconomic status, most deprived quintile versus least deprived (1.34, 1.01–1.78). These predictors were also present within the non-GCA cohort.

Conclusion.

Patients with GCA are more likely to develop cerebrovascular disease or CVD than age-, sex-, and location-matched controls. In common with the non-GCA cohort, patients who are older, male, and from the most deprived compared with least deprived areas have a higher risk of cerebrovascular disease or CVD. Further work is needed to understand how this risk may be mediated by specific behavioral, social, and economic factors.
The Reporting of Patient-reported Outcomes in Studies of Patients with Rheumatoid Arthritis: A Systematic Review of 250 Articles
Authors: Kilic Levent , Erden Abdulsamet , Bingham Clifton O. , Gossec Laure , Kalyoncu Umut
Published: April 2016

Objective.

Patient-reported outcomes (PRO) in rheumatoid arthritis (RA) provide important information regarding disease effect. The study objective was to assess the frequency of PRO use in recent RA studies and compare results with a previous systematic review (SR) in 2005–2007.

Methods.

An SR was performed in PubMed MEDLINE (January 2015). Publications were identified using these MEdical Subject Headings terms: “arthritis, rheumatoid” with a limitation to “humans,” “all adults: 19+ years,” “English,” “published in the last 2 years,” and “clinical trials.” All studies were assessed, whatever their designs. All PRO reported in publications were classified according to general domains of health by 2 authors. Statistics were descriptive.

Results.

Two hundred fifty articles were analyzed. Of them, 113 (45.2%) were randomized controlled trials; 138 different PRO were reported. The most frequent PRO, similar to the 2007 SR, were function (68.0%), pain (40.0%), patient’s global assessment (49.2%), and health-related quality of life (18.4%). Fatigue (14.4%), morning stiffness (10.0%), psychological status (9.6%), productivity losses (6.4%), utility (5.2%), sleep disturbance (2.4%), and coping (2.0%) were rarely reported. Although frequent domains were reported using well-validated questionnaires, the others were reported using heterogeneous questionnaires.

Conclusion.

The PRO collected and reported in RA studies are remarkably consistent with those seen in 2005–2007, and reflect the existing RA Core Set measures. Other domains of health prioritized by patients including fatigue, psychological status, productivity losses, sleep disturbance, and coping remain rarely reported. Further, heterogeneity in outcome measures used presents challenges in interpreting true disease effect and response to therapy.
Canadian Rheumatology Association Meeting, February 17-20, 2016. Introduction, Abstracts, Author Index
Authors: Silverman Earl D.
Published: April 2016

The 71st Annual Meeting of The Canadian Rheumatology Association (CRA) was held at the Fairmont Chateau Lake Louise, Lake Louise, Alberta, Canada, February 17–20, 2016. The program consisted of presentations covering original research, symposia, awards, and lectures. Highlights of the meeting include the following 2016 Award Winners: Distinguished Rheumatologist, Ronald Laxer; Distinguished Investigator, Proton Rahman; Teacher-Educator, Lori Albert; Young Investigator, Nigil Haroon; Best Abstract on Basic Science Research by a Trainee, Liam O’Neil; Best Abstract on Research by a Rheumatology Resident, Valérie Leclair; Best Abstract by a Medical Student, Matthew Jessome; Best Abstract by a Post-Graduate Resident, Hyein Kim; CRA/Arthritis Research Foundation (ARF) Best Epidemiology/Health Services Research Award, Cheryl Barnabe; Summer Studentship Mentor Award, Ines Colmegna; CRA/ARF Best Paediatric Research Award, Lily Lim; CRA/ARF Best Clinical Research Award, Zahi Touma; CRA/ARF Best Basic Science Research Award, Nigil Haroon; Best Abstract on SLE Research by a Trainee — Ian Watson Award, Stephanie Nantes; Best Abstract on Clinical or Epidemiology Research by a Trainee — Phil Rosen Award, Nicolas Richard; Practice Reflection Award — Gold/Silver/Bronze, Henry Averns/Philip Baer and Jean-Pierre Raynauld/Robert Ferrari. Lectures and other events included the Dunlop-Dottridge Lecture: New Paradigms for Inflammatory Arthritis, by Berent Prakken; Keynote Address by Distinguished Investigator Awardee 2016 Proton Rahman: Role of Precision Medicine in Optimizing Quality in Rheumatology Care; State of the Art Lecture: Everything You Must Know About Sleep but are Too Tired to Ask! by James Maas; and the Great Debate: Be it Resolved that Rheumatologists Get with the Times and Use Social Media for Communication with Patients and Research; arguing for: Jason Kur and Michelle Teo; against: Nadia Luca and Sherry Rohekar. Topics such as rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, Sjögren syndrome, psoriatic arthritis, spondyloarthritis, vasculitis, osteoarthritis, fibromyalgia, and their respective diagnoses, treatments, and outcomes are reflected in the abstracts, which we are pleased to publish in this issue of The Journal.
(Re)penser la géographie des migrations au prisme du religieux : le cas des Africains chrétiens au Caire
Authors: Picard Julie
Published: April 2016

En quoi et dans quels buts la géographie des migrations internationales peut-elle être (re)pensée au prisme du religieux ? À partir de recherches empiriques et qualitatives menées au Caire auprès de réfugiés et de migrants chrétiens d’origine subsaharienne, cet article tente de mettre en perspective différentes études en sciences sociales abordant plus ou moins directement les thématiques des migrations, des religions et de l’ancrage urbain. Il interroge les liens se complexifiant entre mobilités spatiales et mobilités religieuses contemporaines. Il examine également différentes formes d’ancrages urbains et de territorialités religieuses en mouvement, en s’attardant sur les espaces vécus et perçus des migrants, redéfinis parfois progressivement par leurs propres croyances.
Distraits et étourdis, de Théophraste au TDA/H
Authors: Bange François
Published: April 2016

Les premiers critères diagnostiques précis du syndrome n’ont été publiés qu’en 1980 dans le DSM III, et en 1993 par l’OMS dans la CIM 10. Mais en réalité, les précurseurs du TDA/H sont nettement plus anciens. Déjà perçue comme une situation affligeante dans l’Antiquité, et comme franchement pathologique avec des références appuyées à la « folie », dès le XVII e  siècle en France, on va en trouver des traces abondantes dans le corpus littéraire. Cet article l’illustrera par quelques exemples.
Le TDAH chez l’adulte et ses comorbidités. Discussion à partir d’un cas clinique d’addiction au Tramadol
Authors: Laffont Isabelle
Published: April 2016

Le TDAH est une entité clinique encore méconnue chez l’adulte en France. De plus, son diagnostic est souvent rendu difficile par la présence de comorbidités, notamment celles addictives. Le cas d’une patiente devenu addict au Tramadol va nous permettre d’illustrer la question du retard actuel au diagnostic du TDAH chez l’adulte. Nous discuterons ensuite de la complexité du sujet des comorbidités du TDAH avec divers troubles présents chez cette patiente et de l’importance d’un diagnostic différentiel aiguisé. Nous aborderons ensuite le traitement du TDAH et ses particularités liées à la présence d’une addiction.
Différentes traditions philosophiques pour le développement des connaissances en sciences infirmières
Authors: Ballard Ariane , Khadra Christelle , Le May Sylvie , Gendron Sylvie
Published: April 2016

Introduction : entreprendre des études doctorales en sciences infirmières engage une réflexion critique sur les traditions philosophiques inhérentes au processus de développement des connaissances. Contexte : le réalisme critique, l’herméneutique, le postmodernisme et le poststructuralisme sont des traditions philosophiques peu explorées en sciences infirmières, mais qui suscitent un intérêt grandissant. Objectif : présenter différentes traditions philosophiques et amorcer une réflexion sur leur apport au développement des connaissances de la discipline infirmière. Méthode : pour chacune des traditions, les fondements ontologiques et épistémologiques sont introduits afin de donner un aperçu de leurs principales caractéristiques. Leur apport au développement des connaissances en sciences infirmières est ensuite discuté. Résultats : l’ontologie renvoie à la réalité pouvant être conçue stratifiée, fixe et changeante, ou multiple, selon la tradition philosophique. De même, l’épistémologie met l’accent sur le pouvoir explicatif des connaissances modélisées, l’intersubjectivité, ou les rapports de pouvoir. Discussion : la diversité des traditions philosophiques constitue une richesse qui peut considérablement contribuer à l’avancement de la discipline infirmière. Conclusion : la clarification des repères philosophiques qui sous-tendent le développement des connaissances est essentielle pour les étudiants au doctorat en sciences infirmières qui entreprennent leurs projets de recherche et la construction de leur programmation de recherche future.
Si l’animal, cet autre signifiant, m’était conté...
Authors: Bélair Sandie
Published: April 2016

Dans certaines cultures, l’animal est considéré comme un partenaire social, et la relation avec lui est, de fait, significative. Dans nos sociétés occidentales modernes, cela ne va de soi, et la frontière entre ce qui relève de l’humain et ce qui ressortit de l’animal est plus ou moins stricte. Toutefois, ces dernières années, on assiste à une requalification des relations entre les animaux humains et non humains. Le bien-être de l’homme, et notamment de l’enfant, dépendrait, aussi, de la présence animale. Le symbole est fort et engage à une exploration du lien entre le tout-petit et l’animal. Qu’est-ce qu’un animal pour un tout-petit ? Participe-t-il au développement de sa vie psychique ? En quoi l’animal est un autre signifiant pour lui ? Et comment cette relation significative peut-elle être « support » d’une relation d’aide ?
Rintintin, Lun, Jo-Fi et Topsy
Authors: Missonnier Sylvain
Published: April 2016

Les relations entre l’homme et l’animal constituent une des lignes de force permanentes de notre culture. Pourtant, généralement mis à distance par une intelligentsia soucieuse d’entretenir la fiction d’une psyché libérée de sa corporéité, les liens entre mammifères humains et animaux sont fréquemment passés sous silence, sinon déniés. La clinique psychanalytique n’échappe pas à cette scotomisation. Trop souvent, les historiens de la psychanalyse et les analystes font impasse sur l’investissement du sujet et des groupes de cette part essentielle de l’environnement non humain. À partir d’une évocation clinique en maternité et de quelques éléments d’histoire, les rudiments d’une psychanalyse canine sont ici esquissés.
Bébé est annoncé, le chien de la famille l’attend...
Authors: Pons Vanessa
Published: April 2016

Nous proposons à travers cet article une réflexion autour de l’arrivée de bébé et du chien du foyer, en croisant l’univers canin avec celui de l’homme et en gardant en tête le questionnement suivant : comment préparer ce changement au mieux pour l’animal et la famille ? Quelles histoires de vie peuvent entraîner des difficultés d’adaptation pour l’animal, et quels risques associés pour le tout-petit ? Enfin, quelles précautions sont à prendre ?
Des chiens dans une crèche
Authors: Dhorne-Corbel Claire
Published: April 2016

Psychomotricité et médiation animale dans un lieu multi-accueil. Un accompagnement riche et original du développement psychomoteur du jeune enfant. Des séances mensuelles de psychomotricité avec des chiens sont proposées mais jamais imposées. Lorsque l’enfant est volontaire, il devient acteur ; il est alors naturellement sollicité dans la globalité de ses potentiels en fonction de son âge et de ses compétences. La motricité libre est le fil conducteur de cette action.
Il était une fois des petits cavaliers, explorateurs d’un jardin d’éveil...
Authors: Pelletier-Milet Claudine
Published: April 2016

Dans le jardin d’éveil « Les petits cavaliers », de très jeunes enfants grandissent au contact de la nature et des animaux. Ils peuvent très tôt s’aventurer sur le site en chevauchant un poney Shetland. L’enfant ressent et construit ses perceptions, ses émotions, ses sentiments de tout-petit. Il se montre prêt à agir et à interagir avec les informations du milieu qui l’entoure. L’enfant se sert de ses sens dans un système d’aller-retour entre lui et son milieu. Par la répétition, en découvrant et redécouvrant la vie du dispositif, il pourra le comprendre, se l’approprier, expérimenter, créer, grandir sereinement.
L’animal, seulement un « terrain de jeu » ?
Authors: Labau-Lalande Émilie
Published: April 2016

Maman de deux enfants, je souhaite partager quelques tranches de vie enrichies par la présence animale, notamment celle de notre chat. Outre les merveilleux temps de jeux qu’il procure à ma grande fille, il ouvre la voie sur un travail initiatique, pour une reconnexion à la nature.
Animal d’accordage, y es-tu ?
Authors: Lerner Claire
Published: April 2016

L’hypothèse de la biophilie suppose que les enfants sont prédisposés à s’occuper du vivant sous ses formes humaines et non humaines. D’ailleurs, les jeunes enfants réagissent aux animaux comme s’ils s’agissaient de pairs intéressants. À travers le prisme de la théorie de l’attachement, cet article évoque la création du lien avec l’animal, et la façon dont la rencontre avec son altérité et sa ressemblance favorise la construction de l’individu. Nous verrons comment l’animal « médiatise » la découverte du tout-petit avec son environnement, et le rôle du parent comme médiateur de la rencontre entre son enfant et l’animal.
Un toutou pas comme les autres en protection de l’enfance...
Authors: Briançon Carole
Published: April 2016

Cet article présente un service de protection de l’enfance qui a choisi d’accompagner la parentalité avec un animal – un chien. En effet, les familles suivies par le Relais éducatif parents-enfants sont quasiment toutes contraintes d’accepter la présence des professionnels sans en comprendre toujours l’intérêt. Le chien joue un rôle fondamental pour créer une relation de confiance avec les parents, puis pour faciliter la mise en place du projet individuel de l’enfant. De plus, le travail sur ses besoins fondamentaux est simplifié lorsqu’on aborde les besoins du chien. Enfin, l’animal contribue à la sécurité affective du tout-petit et lui permet ainsi de se libérer de ses émotions.