bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring spiral narratives with immediate feedback in immersive virtual reality serious games for earthquake emergency training
Authors: Feng Zhenan , González Vicente A. , Mutch Carol , Amor Robert , Cabrera-Guerrero Guillermo
Published: June 2022

Various attempts and approaches have been made to teach individuals about the knowledge of best practice for earthquake emergencies. Among them, Immersive Virtual Reality Serious Games (IVR SGs) have been suggested as an effective tool for emergency training. The notion of IVR SGs is consistent with the concept of problem-based gaming (PBG), where trainees interact with games in a loop of forming a playing strategy, applying the strategy, observing consequences, and making reflection. PBG triggers reflection-on-action, enabling trainees to reform perceptions and establish knowledge after making a response to a scenario. However, in the literature of PBG, little effort has been made for trainees to reflect while they are making a response (i.e., reflection-in-action) in a scenario. In addition, trainees do not have the possibility to adjust their responses and reshape their behaviors according to their reflection-in-action. In order to overcome these limitations, this study proposes a game mechanism, which integrates spiral narratives with immediate feedback, to underpin reflection-in-action and reflective redo in PBG. An IVR SG training system suited to earthquake emergency training was developed, incorporating the proposed game mechanism. A controlled experiment with 99 university students and staff was conducted. Participants were divided into three groups, with three interventions tested: a spiral narrated IVR SG, a linear narrated IVR SG, and a leaflet. Both narrated IVR SGs were effective in terms of immediate knowledge gain and self-efficacy improvement. However, challenges and opportunities for future research have been suggested.
Self-assembling Molecular Medicine for the Subacute Phase of Ischemic Stroke
Authors: Muraoka Takahiro , Ajioka Itsuki
Published: June 2022

Ischemic stroke leads to acute neuron death and forms an injured core, triggering delayed cell death at the penumbra. The impaired brain functions after ischemic stroke are hardly recovered because of the limited regenerative properties. However, recent rodent intervention studies manipulating the extracellular environments at the subacute phase shed new light on the regenerative potency of the injured brain. This review introduces the rational design of artificial extracellular matrix (ECM) mimics using supramolecular peptidic scaffolds, which self-assemble via non-covalent bonds and form hydrogels. The facile customizability of the peptide structures allows tuning the hydrogels' physical and biochemical properties, such as charge states, hydrophobicity, cell adhesiveness, stiffness, and stimuli responses. Supramolecular peptidic materials can create safer and more economical drugs than polymer materials and cell transplantation. We also discuss the importance of activating developmental programs for the recovery at the subacute phase of ischemic stroke. Self-assembling molecular medicine mimicking the ECMs and activating developmental programs may stand as a new drug modality of regenerative medicine in various tissues.
Multiscale simulations of uni-polar hole transport in (In,Ga)N quantum well systems
Authors: O’Donovan Michael , Farrell Patricio , Streckenbach Timo , Koprucki Thomas , Schulz Stefan
Published: June 2022

Understanding the impact of the alloy micro-structure on carrier transport becomes important when designing III-nitride-based light emitting diode (LED) structures. In this work, we study the impact of alloy fluctuations on the hole carrier transport in (In,Ga)N single and multi-quantum well systems. To disentangle hole transport from electron transport and carrier recombination processes, we focus our attention on uni-polar (p-i-p) systems. The calculations employ our recently established multi-scale simulation framework that connects atomistic tight-binding theory with a macroscale drift-diffusion model. In addition to alloy fluctuations, we pay special attention to the impact of quantum corrections on hole transport. Our calculations indicate that results from a virtual crystal approximation present an upper limit for the hole transport in a p-i-p structure in terms of the current-voltage characteristics. Thus we find that alloy fluctuations can have a detrimental effect on hole transport in (In,Ga)N quantum well systems, in contrast to uni-polar electron transport. However, our studies also reveal that the magnitude by which the random alloy results deviate from virtual crystal approximation data depends on several factors, e.g. how quantum corrections are treated in the transport calculations.
European Society of Clinical Pharmacy definition of the term clinical pharmacy and its relationship to pharmaceutical care: a position paper
Authors: Dreischulte Tobias , van den Bemt Bart , Steurbaut Stephane ,   the European Society of Clinical Pharmacy
Published: June 2022

Many definitions of the term clinical pharmacy exist, but a number of ambiguities remain. In order to clarify the European Society of Clinical Pharmacy (ESCP) position on what defines clinical pharmacy, a consultation exercise was conducted among ESCP members with the findings used as the basis for an updated definition. The updated definition clarifies that clinical pharmacy (1) represents both a professional practice and field of research, (2) aims to optimise the utilisation of medicines in order to achieve person-centered and public health goals, (3) as a practice encompasses cognitive, managerial and interpersonal activities targeting all stages of the medicines use process, and as a field of research generates knowledge that informs clinical decision-making, health care organisation or policy, (4) as a practice is restricted to pharmacists, (5) can be practiced regardless of setting, and (6) encompasses pharmaceutical care but is not restricted to it.
Hearing chimeras
Authors: Di Bona Elvira
Published: June 2022

I argue that chimericity is a property that we typically experience when listening to multi-instrumental music. It is the property of hearing as a unified whole a melody or a harmony that does not belong to any single sound source but instead consists of the assembling of melodic or harmonic fragments coming from different sources. Chimericity is not reducible to the low-level audible properties of pitch and loudness; it is cognized at the perceptual level thanks to the auditory mechanism of primitive grouping. My aim is to show that chimericity is a perceptual property, one that we can genuinely hear. In developing this view, I engage with the debate within the philosophy of sense perception between rich vs thin views of the content of perceptual experience.
Extreme environmental temperatures and motorcycle crashes: a time-series analysis
Authors: Zare Sakhvidi Mohammad Javad , Yang Jun , Mohammadi Danial , FallahZadeh Hussein , Mehrparvar Amirhooshang , Stevenson Mark , Basagaña Xavier , Gasparrini Antonio , Dadvand Payam
Published: June 2022

Extreme temperature could affect traffic crashes by influencing road safety, vehicle performance, and drivers’ behavior and abilities. Studies evaluating the impacts of extreme temperatures on the risk of traffic crashes have mainly overlooked the potential role of vehicle air conditioners. The aim of this study, therefore, was to evaluate the effect of exposure to extreme cold and hot temperatures on seeking medical attention due to motorcycle crashes. The study was conducted in Iran by using medical attendance for motorcycle crashes from March 2011 to June 2017. Data on daily minimum, mean and maximum temperature (°C), relative humidity (%), wind velocity (km/h), and precipitation (mm/day) were collected. We developed semi-parametric generalized additive models following a quasi-Poisson distribution with the distributed nonlinear lag model to estimate the immediate and lagged associations (reported as relative risk [RR], and 95% confidence interval [CI]). Between March 2011 and June 2017, 36,079 medical attendances due to motorcycle road traffic crashes were recorded (15.8 ± 5.92 victims per day). In this time period, the recorded temperature ranged from −11.2 to 45.4 °C (average: 25.5 ± 11.0 °C). We found an increased risk of medical attendance for motorcycle crashes (based on maximum daily temperature) at both extremely cold (1st percentile) and hot (99th percentile) temperatures and also hot (75th percentile) temperatures, mainly during lags 0 to 3 days (e.g., RR: 1.12 [95% CI: 1.05: 1.20]; RR: 1.08 [95% CI: 1.01: 1.16]; RR: 1.20 [95% CI: 1.09: 1.32] at lag0 for extremely cold, hot, and extremely hot conditions, respectively). The risk estimates for extremely hot temperatures were larger than hot and extremely cold temperatures. We estimated that 11.01% (95% CI: 7.77:14.06) of the medical attendance for motorcycle crashes is estimated to be attributable to non-optimal temperature (using mean temperature as exposure variable). Our findings have important public health messaging, given the considerable burden associated with road traffic injury, particularly in low- and middle-income countries.
Improving the measurement of self-regulated learning using multi-channel data
Authors: Fan Yizhou , Lim Lyn , van der Graaf Joep , Kilgour Jonathan , Raković Mladen , Moore Johanna , Molenaar Inge , Bannert Maria , Gašević Dragan
Published: June 2022

In recent years, unobtrusive measures of self-regulated learning (SRL) processes based on log data recorded by digital learning environments have attracted increasing attention. However, researchers have also recognised that simple navigational log data or time spent on pages are often not fine-grained enough to study complex SRL processes. Recent advances in data-capturing technologies enabled researchers to go beyond simple navigational logs to measure SRL processes with multi-channel data. What multi-channel data can reveal about SRL processes, and to what extent can the addition of peripheral and eye-tracking data with navigational log data change and improve the measurement of SRL are key questions that require further investigation. Hence, we conducted a study and collected learning trace data generated by 25 university students in a laboratory setting, that aimed to address this problem by enhancing navigational log data with peripheral and eye-tracking data. We developed a trace-based measurement protocol of SRL, which interpreted raw trace data from multi-channel data into SRL processes. Specifically, the study compared the frequency and duration of SRL processes detected, how much duration and times of occurrences of the detected SRL processes were affected or refined. We also used a process mining technique to analyses how temporal sequencing of the detected SRL processes changed by enriching navigational log data with peripheral and eye-tracking data. The results revealed that by adding new data channels, we improved the capture of learning actions and detected SRL processes while enhancing the granularity of the measurement. In comparison to the use of navigational logs only, the completeness of temporal sequencing relationships between SRL processes with multi-channel data improved. In addition, we concluded that eye-tracking data is valuable for measuring and extracting SRL processes, and it should receive more attention in the future.
The Development and Validation of the Ontological Addiction Scale
Authors: Barrows Paul , Shonin Edo , Sapthiang Supakyada , Griffiths Mark D. , Ducasse Déborah , Van Gordon William
Published: June 2022

Ontological Addiction Theory is a metaphysical theory of mental illness which conceptualises psychological suffering in terms of excessive ego-centeredness. This study aimed to develop and validate the Ontological Addiction Scale (OAS) and compare OAS scores with mental health measures. A 31-item prototype scale was developed based on traditional Buddhist theory and contemporary models of addiction. An ego-centeredness form of the Five-Factor Narcissism Inventory (FFNI) was the main criterion measure. For mental health measures, the Patient Health Questionnaire (PHQ-9), Generalised Anxiety Disorder Scale (GAD-7) and Rosenberg Self-Esteem Scale (RSES) were used. The prototype OAS and two shorter versions showed excellent internal consistency and test–retest reliability. Construct validity was evidenced by medium to large correlations with criterion measures. OAS scores showed strong correlations with PHQ-9, GAD-7 and RSES, suggesting a clear relationship between OAS and mental health. The OAS appears to be a valid and reliable instrument suitable for assessing OA.
Prior Coronary Artery Bypass Graft Surgery Impacts 30-day Quality of Life after Percutaneous Coronary Intervention: Evidence from the Victorian Cardiac Outcomes Registry (VCOR)
Authors: Ho Chau L. B. , Brennan Angela , Dinh Diem T. , Lefkovits Jeffrey , Liew Danny , Si Si , Reid Christopher M. , Norman Richard
Published: June 2022

Quality of life following percutaneous coronary intervention (PCI) in patients with coronary artery bypass graft surgery (CABG) has been reported as lower than non-CABG patients, however previous reports pre-date modern developments in PCI and cardiac surgery. This study aimed to examine the 30-day QoL after PCI between patients with and without prior CABG using a contemporary dataset. A retrospective analysis of the Victorian Cardiac Outcomes Registry was undertaken. This study included 36,799 patients who completed the EQ-5D questionnaire that was used to assess the 30-day QoL and was compared between groups with and without prior CABG at baseline. Most of the participants were older than 65 years, more than half were male and had PCI due to acute coronary symptoms (ACS) and nearly 90% of patients received drug eluting stents. Compared to the ‘no prior CABG’ group, the ‘CABG’ group had a significantly higher rate of reporting a health problem (OR 1.30, 95% CI 1.10–1.53), presence of a problem in mobility (OR 1.42, 95% CI 1.15–1.75), personal care (OR 1.49, 95%CI 1.13–1.97) and usual activities (OR 1.39, 95%CI 1.15–1.68), pain/discomfort (OR 1.31, 95%CI 1.11–1.54), and anxiety/depression (OR 1.20, 95%CI 1.02–1.42). Despite modern developments in both PCI and CABG, our study showed a consistent negative association between prior CABG status and 30-day QoL following PCI. There is a need for better targeted cardiac rehabilitation in patients with prior CABG to address their greater relative risk of experiencing poor health.
Latent Class Profiles of Police Violence Exposure in 4 US Cities and Their Associations with Anticipation of Police Violence and Mental Health Outcomes
Authors: Salas-Hernández Leslie , DeVylder Jordan E. , Cooper Hannah L. F. , Duarte Catherine dP , Sewell Alyasah A. , Walker Elizabeth Reisinger , Haardörfer Regine
Published: June 2022

While studying polyvictimization is well established within the broader violence literature and applied to other types of violence, it has yet to be documented whether polyvictimization also presents in patterns of police violence exposure (i.e., neglectful, psychological, physical, and sexual police violence). Our objective was to analyze latent patterns of co-occurring police contact and their associations with mental health. By applying latent class analysis (LCA) methods to the 2016 and 2017 Surveys of Police-Public Encounters (N = 2615), conducted in 4 Northeastern US cities, we identified classes of direct and vicarious police violence and compared sociodemographic characteristics among classes using multinomial regression. Classes were regressed on mental health outcomes. LCA identified four classes of police contact. Compared to Positive Police Contact (33.0%) class members, members of the (a) Extreme Police Violence (4.0%) class reported higher anticipation of future police victimization, psychological distress, and suicide ideations and attempts; they were more likely to be Black, cisgender men, and Latinx; (b) members of the High Police Violence (23.6%) class reported higher anticipation of future police victimization and psychological distress; they were more likely to be Black, Native American, and multiracial; members of the (c) Low Police Contact (39.5%) class had comparable mental health outcomes; they were more likely to report a household income < $19,999. Notably, no participants were unexposed to police contact. Polyvictimization presents in experiences of police violence and disproportionately impacts structurally marginalized people.
Ceratocystiopsis spp. associated with pine- and spruce-infesting bark beetles in Norway
Authors: Jankowiak Robert , Solheim Halvor , Bilański Piotr , Mukhopadhyay Jigeesha , Hausner Georg
Published: June 2022

The genus Ceratocystiopsis (Ophiostomatales, Ascomycota) includes 21 species, which can be found mainly in association with bark beetles in the Northern Hemisphere. A survey of Ceratocystiopsis species associated with bark beetles infesting Picea abies and Pinus sylvestris in Norway yielded 126 isolates, representing Ceratocystiopsis neglecta and Ceratocystiopsis rollhanseniana, and four species described herein as Ceratocystiopsis chalcographii, Ceratocystiopsis debeeria, Ceratocystiopsis norroenii and Ceratocystiopsis troendelagii. The new taxa were morphologically characterised and phylogenetically analysed on the basis of sequence data of multiple loci (ITS, LSU, beta-tubulin (TUB2), calmodulin (CAL) and translation elongation factor 1-alpha (TEF1) genes). Ceratocystiopsis norroenii and C. rollhanseniana were the most frequently isolated species, and the latter species had the wider vector range.
Precipitation Kinetics During Post-heat Treatment of an Additively Manufactured Ferritic Stainless Steel
Authors: Chou Chia-Ying , Karlsson Dennis , Pettersson Niklas Holländer , Helander Thomas , Harlin Peter , Sahlberg Martin , Jansson Ulf , Odqvist Joakim , Lindwall Greta
Published: June 2022

The microstructure response of laser-powder bed fusion (L-PBF)-processed ferritic stainless steel (AISI 441) during post-heat treatments is studied in detail. Focus is on the precipitation kinetics of the Nb-rich phases: Laves (Fe2Nb) and the cubic carbo-nitride (NbC), as well as the grain structure evolution. The evolution of the precipitates is characterized using scanning and transmission electron microscopy (SEM and TEM) and the experimental results are used to calibrate precipitation kinetics simulations using the precipitation module (TC-PRISMA) within the Thermo-Calc Software package. The calculations reproduce the main trend for both the mean radii for the Laves phase and the NbC, and the amount of Laves phase, as a function of temperature. The calibrated model can be used to optimize the post-heat treatment of additively manufactured ferritic stainless steel components and offer a creator tool for process and structure linkages in an integrated computational materials engineering (ICME) framework for alloy and process development of additively manufactured ferritic steels.
TAVI Under Pressure: Intra-balloon Pressure Profiles During Balloon-Expandable TAVR—First Data from a Feasibility Study
Authors: Noterdaeme Timothée , Marx Nikolaus , Theiss Hans , Orban Martin , Roden Daniel , Massberg Steffen , Braun Daniel
Published: June 2022

Our study investigated the feasibility to measure pressure profiles inside the inflation balloon during direct implantation of Edwards Sapien 3 ultra-prostheses using an additional syringe with a digital pressure read-out. Pressure profiles of 15 patients for 26 mm valve size were analyzed. Uniform patterns were found for 5 patients similar to those of previously acquired in vitro curves. 10 patients showed strikingly different pressure profiles compared to the above-mentioned group, marked by an earlier pressure increase, single or multiple pressure drops or higher overall pressure. Measuring the percentage of under-expansion of the prostheses, using calibrated angiographic projections revealed a significant difference between both groups. Our data raises the hypothesis that the acquisition of pressure profiles might help to better understand not only the implantation procedure itself but also the highly individual patient-device interaction, offering new information and a new perspective on optimization of TAVR implantation in the future.
A tEMTing target? Clinical and experimental evidence for epithelial-mesenchymal transition in the progression of cutaneous squamous cell carcinoma (a scoping systematic review)
Authors: Genenger Benjamin , Perry Jay R. , Ashford Bruce , Ranson Marie
Published: June 2022

Cutaneous squamous cell carcinoma (cSCC) is a disease with globally rising incidence and poor prognosis for patients with advanced or metastatic disease. Epithelial-mesenchymal transition (EMT) is a driver of metastasis in many carcinomas, and cSCC is no exception. We aimed to provide a systematic overview of the clinical and experimental evidence for EMT in cSCC, with critical appraisal of type and quality of the methodology used. We then used this information as rationale for potential drug targets against advanced and metastatic cSCC. All primary literature encompassing clinical and cell-based or xenograft experimental studies reporting on the role of EMT markers or related signalling pathways in the progression of cSCC were considered. A screen of 3443 search results yielded 86 eligible studies comprising 44 experimental studies, 22 clinical studies, and 20 studies integrating both. From the clinical studies a timeline illustrating the alteration of EMT markers and related signalling was evident based on clinical progression of the disease. The experimental studies reveal connections of EMT with a multitude of factors such as genetic disorders, cancer-associated fibroblasts, and matrix remodelling via matrix metalloproteinases and urokinase plasminogen activator. Additionally, EMT was found to be closely tied to environmental factors as well as to stemness in cSCC via NFκB and β-catenin. We conclude that the canonical EGFR, canonical TGF-βR, PI3K/AKT and NFκB signalling are the four signalling pillars that induce EMT in cSCC and could be valuable therapeutic targets. Despite the complexity, EMT markers and pathways are desirable biomarkers and drug targets for the treatment of advanced or metastatic cSCC.

Graphical Abstract
Carrier detection probabilities for autosomal recessive variants in unrelated and consanguineous couples — an evaluation of the 86 genes of the ACMG ‘Tier 3’ panel
Authors: Schmidtke Jörg , Krawczak Michael
Published: June 2022

Carrier screening for autosomal recessive variants has become a cornerstone of community and public health genetics. While the first carrier screening programs were confined to conditions with relatively high prevalence, and hence well-known carrier frequency, the number of candidate genes has increased greatly since the advent of high-throughput DNA sequencing technologies. The epidemiological database of the ensuing gene panels is mostly sparse, and judgement of their performance is, therefore, anything but straightforward. We therefore derived estimates of the carrier detection probabilities among non-consanguineous and consanguineous couples as expected using the ‘Tier 3’ carrier screening gene panel recently recommended by the American College of Medical Genetics (ACMG). For non-Finnish Europeans, the respective estimate for unrelated couples equals 0.63%, implying that the ACMG Tier 3 panel accounts for over 90% of the genetic load for autosomal recessive diseases in this population. Among the offspring of first cousins, the corresponding incidence is expected to be tenfold higher, an increase still consistent with previous estimates of the overall risk of birth defects for this type of mating. Our considerations are intended to aid the implementation of carrier screening programs and to provide additional support to reproductive counselling and to obtaining informed consent.
Short-term effects of continuous cover forestry on forest biomass production and biodiversity: Applying single-tree selection in forests dominated by Picea abies
Authors: Ekholm Adam , Axelsson Petter , Hjältén Joakim , Lundmark Tomas , Sjögren Jörgen
Published: June 2022

The rotation forestry system provides high biomass production, but could also have a negative impact on species sensitive to disturbance. Continuous cover forestry (CCF) could contribute to solving these conflicting goals, but its feasibility in nutrient limited boreal forests is yet unresolved. In a unique experiment, we simultaneously assessed the short-term effect of single-tree selection on both biomass production and biodiversity (vascular plants, bryophytes, wood-inhabiting fungi), and tested fertilization as a way to mediate growth-biodiversity trade-offs. We found that unharvested stands and stands subjected to single-tree selection had a similar species assemblage of vascular plants, bryophytes, and wood-inhabiting fungi. Fertilization increased growth by 37% and induced shifts in two understory species (favoring the grass Avenella flexuosa and disfavoring the bryophyte Hylocomium splendens). We conclude that single-tree selection may become a useful tool to enhance biodiversity in managed forests.
Pattern, Forms and Bibliometric Analysis for Systematic Study of Silica-Supported Heterogeneous Solar Photocatalyst for Lannate Insecticide Abatement from Aqueous Stream
Authors: Tony Maha A.
Published: June 2022

Agro-industrial streams with high toxic loadings must undergo for treatment prior to final disposal. Thus, the current investigation aimed to apply cheap and naturally available materials to explore sustainable heterogeneous solar/Fenton reaction for insecticide abatement form waste streams. Iron was collected from the wastewater stream after coal industry. The sand pellets were used as iron support material which acts as a heterogeneous solar photo-catalyst like modified Fenton reaction. The prepared catalysts were characterized using X-ray diffraction (XRD) and scanning electron microscope (SEM) for characterization. System parameters variables were studied using the modified catalysts. Although the acidic pH showed maximal removal efficiency, the catalyst could also work at a wide pH range with a reduced activity. The optimum conditions of the newly synthesized modified Fenton composite showed 103, 45 mg/L for H2O2 and catalyst, respectively, at pH 2.8 within 90 min under solar irradiation for maximal Lannate oxidation reached to 98%. Moreover, the increase in Lannate concentration loading results in a reduction in the removal efficiency from 98 to 96% when the Lannate loading increased from 10 to 50 ppm, although further increase of Lannate (100 ppm) results in only 2% removal. Also, temperature effect was displayed and the high temperature range was unfavorable. The kinetics of Lannate removal was dependent on operation temperature and following the first-order kinetic model. The thermodynamic parameters values settled the system is non-spontaneous in nature, proceeds in endothermic circumstances and working in a low energy barrier (34.54 kJ mol−1). Recyclability confirms the sustainability of the catalyst, and the third cycle catalytic use attained 28% Lannate removal.
A novel empirical wavelet SODP and spectral entropy based index for assessing the depth of anaesthesia
Authors: Schmierer Thomas , Li Tianning , Li Yan
Published: June 2022

The requirement for anaesthesia during modern surgical procedures is unquestionable to ensure a safe experience for patients with successful recovery. Assessment of the depth of anaesthesia (DoA) is an important and ongoing field of research to ensure patient stability during and post-surgery. This research addresses the limitations of current DoA indexes by developing a new index based on electroencephalography (EEG) signal analysis. Empirical wavelet transformation (EWT) methods are employed to extract wavelet coefficients before statistical analysis. The features Spectral Entropy and Second Order Difference Plot are extracted from the wavelet coefficients. These features are used to train a new index, SSEDoA, utilising a Support Vector Machine (SVM) with a linear kernel function. The new index accurately assesses the DoA to illustrate the transition between different anaesthetic stages. Testing was undertaken with nine patients and an additional four patients with low signal quality. Across the nine patients we tested, an average correlation of 0.834 was observed with the Bispectral (BIS) index. The analysis of the DoA stage transition exhibited a Choen's Kappa of 0.809, indicative of a high agreement.
Prenatal 2-D and 3-D Ultrasound Characteristics of a Case of Fetal Orofacial Macrocystic Lymphatic Malformation and its Postnatal Management with Intralesional Bleomycin
Authors: Elango Nithya , Vikraman Seneesh Kumar , Saranyadevi A. C. , Sengodan Chithra , Sengottiyan Kumar Athapanur
Published: June 2022

Fetal lymphatic malformations (FLM) are benign hamartomatous lesions of the lymphatic vasculature usually localized in the cervicofacial and axillary regions and less frequently in the abdomen or inguinal areas, with an overall incidence of 1:6000 to 1:16,000 live births. FLM has a potential association with chromosomal aneuploidies such as Trisomy 21,18,13, Turner syndrome and genetic conditions such as Noonan syndrome, and with an excess risk for co-existing structural defects. A progressive increase in the dimensions of FLM's may result in polyhydramnios, hydrops, intrauterine fetal demise, airway obstruction and neonatal respiratory distress. We report a case of fetal orofacial lymphatic malformation detected in the mid-trimester anomaly scan with details of two- and three-dimensional imaging, prenatal counseling, cytogenetic workup, serial ultrasound surveillance, postnatal magnetic resonance imaging, and management with an intra-lesional sclerosing agent. The case depicts the strategic importance of multidisciplinary inputs in managing cases of prenatally diagnosed oral-cervical masses for optimizing perinatal outcome.
A virtual test and evaluation method for fully mechanized mining production system with different smart levels
Authors: Xie Jiacheng , Ge Fuxiang , Cui Tao , Wang Xuewen
Published: June 2022

A smart fully mechanized coal mining working face is comprised of various heterogeneous equipment that work together in unknown coal seam environments. The goal is to form a smart operational system with comprehensive perception, decision-making, and control. This involves many work points and complex coupling relationships, indicating it needs to be performed in stages and coordinated to address key problems in all directions and along multiple points. However, there are no existing unified test or analysis tools. Therefore, this study proposed a virtual test and evaluation method for a fully mechanized mining production system with different smart levels. This is based on the concept of “real data processing–virtual scene construction–setting key information points–virtual operation and evaluation.” The actual operational data for a specific working face geology and equipment were reasonably transformed into a visual virtual scene through a movement relationship model. The virtual operations and mining conditions of the working face were accurately reproduced. Based on the sensor and execution error analyses for different smart levels, the input interface for sensing, decision-making, and control was established for each piece of equipment, and an operation evaluation system was constructed. The system comprehensively simulates and tests the key points of sensing decision-making and control with various smart levels. The experimental results showed that the virtual scene constructed based on actual operational data has a high simulation degree. Users can simulate, analyze, and evaluate the overall operations of the smart mining 2.0–4.0 working face by inputting key information. The future direction for the smart development of fully mechanized mining is highlighted.
Does international trade favor proximity in cultural beliefs?
Authors: Franco Chiara , Maggioni Daniela
Published: June 2022

Cultural proximity has been considered as a crucial determinant of bilateral trade flows. Scant emphasis has, instead, been devoted to the investigation of the opposite direction of causality. International trade eases contacts and increases trust among contracting parties and may, then, promote the spread of cultural beliefs across borders. By using World and European Values Surveys data, we provide evidence on the role of trade flows in favoring countries’ cultural convergence for a large sample of countries over the period 1989–2014. Results confirm that international trade narrows differences in cultural beliefs and attitudes, but just when trade partners share some culture-related traits. Common ancestry, religion and legal system as well as high historical bilateral migration flows are necessary conditions for trade reducing cultural distance. Also, the convergence effect turns to be completely driven by trade flows of differentiated goods which entail relationship-specific investments and a deeper commitment between contracting parties.
Pterin-lysine photoadduct: a potential candidate for photoallergy
Authors: Farías Jesuan J. , Lizondo-Aranda Paloma , Thomas Andrés H. , Lhiaubet-Vallet Virginie , Dántola M. Laura
Published: June 2022

Photoallergy is a photosensitivity disorder associated with a modified ability of the skin to react to the combined effect of drugs and sunlight. It has been attributed to the covalent conjugation of proteins with a photosensitizer, yielding modified macromolecules that can act as antigen provoking the immune system response. The potential role of some endogenous compounds as photoallergens has not been fully established. It has been previously proposed that pterins, which are endogenous photosensitizers present in human skin under pathological conditions, are able to covalently bind to proteins. Here, we evaluated the capability of pterin (Ptr) to form photoadducts with free Lysine (Lys) and poly-l-lysine (poly-Lys). The findings obtained using chromatographic and spectroscopic tools, confirm the formation of photoadducts of Ptr with Lys residues. With poly-Lys the resulting adduct retains the spectroscopic properties of the photosensitizer, suggesting that the aromatic Ptr structure is conserved. On the other hand, the photoproduct formed with free Lys does not behave like Ptr, which suggests that if this product is a photoadduct, a chemical modification may have occurred during the photochemical reaction that alters the pterin moiety.

Graphical abstract
Mathematics and Metaphilosophy
Authors: Clarke-Doane Justin
Published: June 2022

This Element discusses the problem of mathematical knowledge, and its broader philosophical ramifications. It argues that the challenge to explain the (defeasible) justification of our mathematical beliefs ('the justificatory challenge'), arises insofar as disagreement over axioms bottoms out in disagreement over intuitions. And it argues that the challenge to explain their reliability ('the reliability challenge'), arises to the extent that we could have easily had different beliefs. The Element shows that mathematical facts are not, in general, empirically accessible, contra Quine, and that they cannot be dispensed with, contra Field. However, it argues that they might be so plentiful that our knowledge of them is unmysterious. The Element concludes with a complementary 'pluralism' about modality, logic and normative theory, highlighting its surprising implications. Metaphysically, pluralism engenders a kind of perspectivalism and indeterminacy. Methodologically, it vindicates Carnap's pragmatism, transposed to the key of realism.
3 x Phonology
Authors: Scheer Tobias
Published: June 2022

What does it take to run a full substance-free phonology (SFP)? Because in classical approaches only items below the skeleton have phonetic properties that, according to SFP, need to be expunged, current work in SFP only ever concerns segmental aspects. If substance is removed from segmental representation and primes and computation are therefore arbitrary, the non-trivial question arises: how can such a system communicate with a system where primes and computation are not arbitrary (at and above the skeleton)? The two phonologies below and at / above the skeleton that exist in production are complemented with a third phonology that occurs upon lexicalization, that is, when L1 learners or adults transform the acoustic signal into a stored representation. The core of this article argues that this broad architecture is inhabited by three distinct computational systems along the classical feature geometric divisions: Son(ority) is located at and above the skeleton, while Place and Lar(yngeal) live below the skeleton. The question then is how a multiple-module spell-out works, that is, how ingredients from three distinct vocabularies can be mapped onto a single phonetic item. It is argued that the skeleton plays a central role in this conversion.
Buoyancy effects on film boiling heat transfer from a sphere at low velocities
Authors: Singh Rishabh , Pal Anikesh , De Santanu
Published: June 2022

A theoretical model is developed for the forced convection film boiling phenomenon over a heated sphere moving vertically downwards in the water. Unprecedented compared with the previous analytical studies, this model accounts for the buoyancy effects while solving the momentum and energy equations in the vapour phase to obtain the velocity and the temperature distribution in terms of the vapour boundary layer thickness. To calculate the vapour boundary layer thickness, an energy balance is applied at the vapour–liquid interface. The flow of liquid around the sphere is considered to be governed by potential theory, and the energy equation in liquid is then solved for the known velocity distribution. We find that the vapour boundary layer thickness increases with an increase in the sphere temperature, the bulk water temperature and a decrease in the free stream velocity. This further results in a decrease in the film boiling heat transfer coefficient. The present study concludes that at low free stream velocities (

${<}0.5\, {\rm m}\,{\rm s}^{-1}$

) buoyancy becomes significant in delaying the separation, and when the velocity is further reduced the separation angle approaches

$180^{\circ}$

.
Heat transport and temperature boundary-layer profiles in closed turbulent Rayleigh–Bénard convection with slippery conducting surfaces
Authors: Huang Maojing , Wang Yin , Bao Yun , He Xiaozhou
Published: June 2022

We report direct numerical simulations (DNS) of the Nusselt number$Nu$, the vertical profiles of mean temperature$\varTheta (z)$and temperature variance$\varOmega (z)$across the thermal boundary layer (BL) in closed turbulent Rayleigh–Bénard convection (RBC) with slippery conducting surfaces ($z$is the vertical distance from the bottom surface). The DNS study was conducted in three RBC samples: a three-dimensional cuboid with length$L = H$and width$W = H/4$($H$is the sample height), and two-dimensional rectangles with aspect ratios$\varGamma \equiv L/H = 1$and$10$. The slip length$b$for top and bottom plates varied from$0$to$\infty$. The Rayleigh numbers$Ra$were in the range$10^{6} \leqslant Ra \leqslant 10^{10}$and the Prandtl number$Pr$was fixed at$4.3$. As$b$increases, the normalised$Nu/Nu_0$($Nu_0$is the global heat transport for$b = 0$) from the three samples for different$Ra$and$\varGamma$can be well described by the same function$Nu/Nu_0 = N_0 \tanh (b/\lambda _0) + 1$, with$N_0 = 0.8 \pm 0.03$. Here$\lambda _0 \equiv L/(2Nu_0)$is the thermal boundary layer thickness for$b = 0$. Considering the BL fluctuations for$Pr>1$, one can derive solutions of temperature profiles$\varTheta (z)$and$\varOmega (z)$near the thermal BL for$b \geqslant 0$. When$b=0$, the solutions are equivalent to those reported by Shishkinaet al.(Phys. Rev. Lett., vol. 114, 2015, 114302) and Wanget al.(Phys. Rev. Fluids, vol. 1, 2016, 082301(R)), respectively, for no-slip plates. For$b > 0$, the derived solutions are in excellent agreement with our DNS data for slippery plates.
Opposition control of turbulent spots
Authors: Wang Y.X. , Choi K.-S. , Gaster M. , Atkin C. , Borodulin V. , Kachanov Y.
Published: June 2022

Opposition control of artificially initiated turbulent spots in a laminar boundary layer was carried out in a low-turbulence wind tunnel with the aim to delay transition to turbulence by modifying the turbulent structure within the turbulent spots. The timing and duration of control, which was carried out using wall-normal jets from a spanwise slot, were pre-determined based on the baseline measurements of the transitional boundary layer. The results indicated that the high-speed region of the turbulent spots was cancelled by opposition control, which was replaced by a carpet of low-speed fluid. The application of the variable-interval time-averaging technique on the velocity fluctuation signals demonstrated a reduction in both the burst duration and intensity within the turbulent spots, but the burst frequency was increased.
A secondary modulation mechanism for aerofoil tonal self-noise generation
Authors: Yang Yannian , Pröbsting Stefan , Li Pengyu , Liu Yu , Li Ye
Published: June 2022

Acoustic emission of a NACA 0012 aerofoil is investigated over a range of free-stream velocities. Acoustic spectra show a dominant tone and two sets of weaker side tones characterised by different frequency intervals. The frequency of the dominant tones in the acoustic spectra varies with velocity in a ladder-type structure. With increasing Reynolds number, the spectrum becomes progressively more broadband in nature. Through synchronised particle image velocimetry and acoustic measurements, the aeroacoustic noise generation mechanisms, resulting in different spectral characteristics and modulation types, are further investigated. A separation bubble and related significant velocity fluctuations are observed on the pressure side. Pressure side velocity spectra show characteristics similar to the acoustic ones, whereas velocity spectra on the suction side feature broadband characteristics. These findings confirm that noise emission is dominated by pressure side events for the Reynolds number range of this study, i.e.

$2 \times 10^{5}$

–

$7 \times 10^{5}$

. As the acoustic emission is defined by coherent flow structures, the proper orthogonal decomposition method is adopted to facilitate the understanding of the relation between the complex flow field and acoustic emission. Side tones in the acoustic spectra are attributed to two different modulation mechanisms in the aeroacoustic source region near the trailing edge. By aligning the sound pressure time history and the time coefficients of the dominant modes, the primary modulation of the dominant tone is found to be related to the amplitude modulation of the high-frequency velocity fluctuations associated with the acoustic feedback loop. A secondary modulation is attributed to periodic variation of the separation bubble and, therefore, variation in the roll-up of the shear layer, which results in a modulation of the amplitude of the velocity fluctuations associated with the convecting vortices at the trailing edge.
Wall-attached structures in a drag-reduced turbulent channel flow
Authors: Yoon Min , Sung Hyung Jin
Published: June 2022

We explore wall-attached structures in a drag-reduced turbulent channel flow with the Navier slip boundary condition. Three-dimensional coherent structures of the streamwise velocity fluctuations (u) are examined in an effort to assess the influence of wall-attached u structures on drag reduction. We extract the u clusters from the direct numerical simulation (DNS) data; the DNS data for the no-slip condition are included for comparison. The wall-attached structures, which are physically adhered to the wall, in the logarithmic region are self-similar with their height and contribute to the presence of logarithmic behaviour. The influence of the streamwise slip on wall-attached structures is limited up to the lower bound of the logarithmic region. Although wall-attached self-similar structures (WASS) slide at the wall, the formation and hierarchy of WASS are sustained. Weakened mean shear by the streamwise slip results in a diminution in the population density of wall-attached structures within the buffer layer, leading to sparse population of WASS. In contrast, the space occupied by WASS in the fluid domain increases. The streamwise slip induces long tails in the near-wall part of WASS, reminiscent of the footprints of large-scale motions. Both a decrease in the population density of WASS and a reduction in the density of skin friction of WASS are responsible for the overall drag reduction.
Seismic response of cylinder assemblies in axial flow
Authors: Capanna Roberto , Ricciardi Guillaume , Sarrouy Emmanuelle , Eloy Christophe
Published: June 2022

Earthquakes are a great challenge for the safety of nuclear reactors. To address this challenge, we need to better understand how the reactor core responds to seismic forcing. The reactor core is made of fuel assemblies, which are themselves composed of flexible fuel rods immersed in a strong axial flow. This gives rise to strongly coupled fluid–structure interactions whose accurate modelling generally requires high computational costs. In this paper, we introduce a new model able to capture the mechanical response of the reactor core subjected to seismic forcing with low computational costs. This model is based on potential flow theory for the fluid part, and Euler–Bernoulli beam theory for the structural part, allowing us to predict the response to seismic forcing in presence of axial flow. The linear equations are solved in the Fourier space to decrease computational time. For validation purposes, first we use the proposed model to compute the response of a single cylinder in axial flow. We then implement a multiple-cylinder geometry made of four fuel assemblies, each made of$8\times 8$cylinders, corresponding to an experimental facility available at CEA. The comparison between numerical results and experiments shows good agreement. The model can predict correctly the added mass. It can also capture qualitatively the coupling between assemblies and the effect of confinement. This shows that a potential flow approach can give insight into the complex fluid–structure interactions within a nuclear reactor and, in particular, be used to predict the response to seismic forcing at low computational cost.
Business, pleasure or both?: motivations and changing motivation of self-initiated expatriates
Authors: Despotovic William Vuk , Hutchings Kate , McPhail Ruth
Published: June 2022

Responding to calls for more knowledge about the motivations (and changing motivations) of self-initiated expatriates (SIEs), this qualitative research examines 58 Australian SIEs working in culturally (dis)similar host contexts, to address the question:Why are Australian SIEs motivated to expatriate to South Korea or the United Kingdom?The findings demonstrate that, although personal/lifestyle considerations are important to SIEs, career-related considerations are either primary or become more prevalent following expatriation. The findings reveal that, while SIEs expatriate with particular motivations, over time their motivations may change as other factors determine desire to stay/leave a host country. Drawing on self-determination theory (SDT), the research highlights variations in extrinsic and intrinsic motivations of SIEs including those who intended to utilise their expatriation as part of a boundaryless career and those who unintentionally found themselves focused on career. Knowledge of (changing) motivations is salient to organisations' selection decisions and support for international employees.