bluuebunny/crossref_metadata_2025 huggingface dataset:
Volumetric modulated arc therapy for hippocampal-sparing prophylactic cranial irradiation: Planning comparison of Halcyon and C-arm accelerators
Authors: Sun Tao , Lin Xiutong , Li Kuo , Qiu Qingtao , Duan Jinghao , Zhang Guifang , Yin Yong
Published: March 2023

Background

The purpose of the study was to evaluate the dosimetry of the Halcyon in prophylactic cranial irradiation (PCI) with volumetric modulated arc therapy (VMAT) and hippocampal-sparing for small cell lung cancer (SCLC).

Methods

Five VMAT plans were designed on CT images of 15 patients diagnosed with SCLC and received PCI. Three plans with two full arcs were generated on the Trilogy and the TrueBeam accelerators, and flattening filter (FF) and flattening filter free (FFF) modes were used on TrueBeam. Two Halcyon plans with two and three full arcs were generated, referred to as H-2A and H-3A, respectively. The prescription dose was 25 Gy in 2.5-Gy fractions. The dose limit for hippocampus were D100 ≤ 9Gy and Dmax ≤ 16Gy. The Wilcoxon matched-paired signed-rank test was used to evaluate the significance of the observed differences between the five plans.

Results

H-2A plans significantly increased the D2 of PTV, and H-3A plans showed comparable or even better target dosimetry (better conformity) compared to the three plans on C-arm accelerators. Compared to T and TB plans, the two Halcyon plans significantly reduced the D100 and mean doses of bilateral hippocampus, the mean doses of eyeballs, and the maximum doses of lenses. D100 of hippocampus was reduced in TrueBeam plans comparing to Trilogy plans. The FFF plans on TrueBeam also represented advantages in Dmean and D100 of hippocampas, Dmean and Dmax of eyeballs, and the Dmax of lenses compared to FF plans. Halcyon plans and TrueBeam plans with FFF mode increased the MUs compared to FF plans. Comparing to H-2A, the H-3A plans exhibited additional dosimetric advantages, including D2, CI and HI of PTV, as well as the maximum and mean doses of hippocampus and eyeballs, and the maximum doses of optic nerves and brainstem. The two Halcyon plans significantly reduced the delivery time and showed the higher gamma passing rate than the three plans of C-arm accelerators.

Conclusions

Compared with the C-arm accelerators, the dose of hippocampus and the delivery times on Halcyon are relatively significantly reduced for hippocampal-sparing PCI. Three arcs are recommended for VMAT plans with the Halcyon in hippocampal-sparing PCI.
Natural products regulate mitochondrial function in cognitive dysfunction—A scoping review
Authors: Tuo Jinmei , Peng Yan , Linghu Yushuang , Tao Ming , Huang Shiming , Xu Zucai
Published: March 2023

Medicines from natural products can not only treat neurodegenerative diseases but also improve the cognitive dysfunction caused by treatments with western medicines. This study reviews the literature related to the regulation of mitochondrial participation in cognitive function by natural products. In this study, we focused on English articles in PubMed, Web of Science, and Google Scholar, from 15 October 2017, to 15 October 2022. Fourteen studies that followed the inclusion criteria were integrated, analyzed, and summarized. Several studies have shown that natural products can improve or reduce cognitive dysfunction by ameliorating mitochondrial dysfunction. These results suggest that natural products may serve as new therapeutic targets for neurodegenerative diseases.
Anti-angiogenic therapy in ovarian cancer: Current understandings and prospects of precision medicine
Authors: Mei Chao , Gong Weijing , Wang Xu , Lv Yongning , Zhang Yu , Wu Sanlan , Zhu Chunqi
Published: March 2023

Ovarian cancer (OC) remains the most fatal disease of gynecologic malignant tumors. Angiogenesis refers to the development of new vessels from pre-existing ones, which is responsible for supplying nutrients and removing metabolic waste. Although not yet completely understood, tumor vascularization is orchestrated by multiple secreted factors and signaling pathways. The most central proangiogenic signal, vascular endothelial growth factor (VEGF)/VEGFR signaling, is also the primary target of initial clinical anti-angiogenic effort. However, the efficiency of therapy has so far been modest due to the low response rate and rapidly emerging acquiring resistance. This review focused on the current understanding of the in-depth mechanisms of tumor angiogenesis, together with the newest reports of clinical trial outcomes and resistance mechanism of anti-angiogenic agents in OC. We also emphatically summarized and analyzed previously reported biomarkers and predictive models to describe the prospect of precision therapy of anti-angiogenic drugs in OC.
Fractional critical slowing down in some biological models
Authors: Alharbey R. A. , Hassan S. S.
Published: March 2023

The critical slowing down (CSD) phenomenon of the switching time in response to perturbation β (0 < β < 1) of the control parameters at the critical points of the steady state bistable curves, associated with two biological models (the spruce budworm outbreak model and the Thomas reaction model for enzyme membrane) is investigated within fractional derivative forms of order α (0 < α < 1) that allows for memory mechanism. We use two definitions of fractional derivative, namely, Caputo’s and Caputo-Fabrizio’s fractional derivatives. Both definitions of fractional derivative yield the same qualitative results. The interplay of the two parameters α (as memory index) and β shows that the time delay τD can be reduced or increased, compared with the ordinary derivative case (α = 1). Further, τD fits: (i) as function of β the scaling inverse square root formula 1/β at fixed fractional derivative index (α < 1) and, (ii) as a function of α (0 < α < 1) an exponentially increasing form at fixed perturbation parameter β.
Sports health monitoring management system based on artificial intelligence algorithm
Authors: Tong Yunlong , Ye Lina
Published: March 2023

With the improvement of people's material living standards, more and more people start to pay attention to health issues. This paper takes the health field as the main research object, and discusses the current development and status quo of the health field. Through literature review, it is found that the current health field mainly focuses on the single monitoring of a certain organ or body function, and there are limitations in systematic health monitoring research, and most of the research stays at the stage of human body monitoring. Therefore, this paper intends to design a sports health monitoring and management system based on artificial intelligence. The system is mainly divided into a body temperature monitoring module, a blood pressure monitoring module and an exercise monitoring module, through which the user's health data is monitored. In order to ensure the practicability of the system, this paper selects three common life states in daily life for experimental testing, namely exercise state, rest state and sick state. The experimental test results show that each monitoring module can operate correctly and normally under three different states. The lowest temperature was 36.5° and the highest temperature was 37.1° under the exercise state. The lowest blood pressure is 70 in the resting state, and the highest blood pressure is 80. In the sick state, the maximum value of motor threshold is 0.2, the minimum value is 0.1, and the threshold difference is 0.1. Each module reads and backs up relevant data, and sends it to the platform for intelligent analysis. The platform will analyze and compare the data of different modules at the same time, judge the health status of the user at that time, choose whether to issue a health alert for the user, and finally complete the entire system process of the health monitoring management system. This proves that the sports health monitoring management system based on artificial intelligence algorithm designed in this paper is effective and feasible.
Automated recognition of asymmetric gait and fatigue gait using ground reaction force data
Authors: Gao Zixiang , Zhu Yining , Fang Yufei , Fekete Gusztáv , Kovács András , Baker Julien S. , Liang Minjun , Gu Yaodong
Published: March 2023

Introduction: The purpose of this study was to evaluate the effect of running-induced fatigue on the characteristic asymmetry of running gait and to identify non-linear differences in bilateral lower limbs and fatigued gait by building a machine learning model.

Methods: Data on bilateral lower limb three-dimensional ground reaction forces were collected from 14 male amateur runners before and after a running-induced fatigue experiment. The symmetry function (SF) was used to assess the degree of symmetry of running gait. Statistical parameter mapping (Paired sample T-test) algorithm was used to examine bilateral lower limb differences and asymmetry changes pre- and post-fatigue of time series data. The support vector ma-chine (SVM) algorithm was used to recognize the gait characteristics of both lower limbs before and after fatigue and to build the optimal algorithm model by setting different kernel functions.

Results: The results showed that the ground reaction forces were asymmetrical (SF > 0.5) both pre-and post-fatigue and mainly concentrated in the medial-lateral direction. The asymmetry of the medial-lateral direction increased significantly after fatigue (p < 0.05). In addition, we concluded that the polynomial kernel function could make the SVM model the most accurate in classifying left and right gait features (accuracy of 85.3%, 82.4%, and 82.4% in medial-lateral, anterior-posterior and vertical directions, respectively). Gaussian radial basis kernel function was the optimal kernel function of the SVM algorithm model for fatigue gait recognition in the medial-lateral and vertical directions (accuracy of 54.2% and 62.5%, respectively). Moreover, polynomial was the optimal kernel function of the anterior-posterior di-rection (accuracy = 54.2%).

Discussion: We proved in this study that the SVM algorithm model depicted good performance in identifying asymmetric and fatigue gaits. These findings can provide implications for running injury prevention, movement monitoring, and gait assessment.
Application of third-generation sequencing to herbal genomics
Authors: Gao Longlong , Xu Wenjie , Xin Tianyi , Song Jingyuan
Published: March 2023

There is a long history of traditional medicine use. However, little genetic information is available for the plants used in traditional medicine, which limits the exploitation of these natural resources. Third-generation sequencing (TGS) techniques have made it possible to gather invaluable genetic information and develop herbal genomics. In this review, we introduce two main TGS techniques, PacBio SMRT technology and Oxford Nanopore technology, and compare the two techniques against Illumina, the predominant next-generation sequencing technique. In addition, we summarize the nuclear and organelle genome assemblies of commonly used medicinal plants, choose several examples from genomics, transcriptomics, and molecular identification studies to dissect the specific processes and summarize the advantages and disadvantages of the two TGS techniques when applied to medicinal organisms. Finally, we describe how we expect that TGS techniques will be widely utilized to assemble telomere-to-telomere (T2T) genomes and in epigenomics research involving medicinal plants.
Identification of resistant sources from Glycine max against soybean cyst nematode
Authors: Lian Yun , Yuan Ming , Wei He , Li Jinying , Ding Binke , Wang Jinshe , Lu Weiguo , Koch Georg
Published: March 2023

Soybean cyst nematode (SCN, Heterodera glycines, HG) is one of the severe pests in plant-parasitic nematodes, which impairs root development and causes severe losses in soybean production worldwide. Breeding SCN-resistant cultivars is an important measure for securing harvests without affecting the environment, as can be done with pesticides. The majority of genetic resources for plant pest resistances are found in wild or closely related species which are often difficult to use in breeding due to crossing barriers or close linkage with unfavorable agronomic traits. In this study, 12 soybean cultivars were evaluated for their marker haplotype at the rhg1 and Rhg4 SCN resistance loci and their SCN resistance tested against multiple races in environmentally controlled bioassays. The results showed that all 12 cultivars displayed Peking-type resistance marker haplotypes and all of them proved to be resistant to multiple SCN races. These cultivars provide potential for improving H. glycines resistance of soybean as donor parent in breeding and can contribute to reduce SCN field populations as part of a sustainable agriculture management.
The impact of post-encoding alcohol consumption on episodic memory recall and remember-know responses in heavy drinkers
Authors: Butterworth Benjamin , Hand Christopher James , Lorimer Karen , Gawrylowicz Julie
Published: March 2023

Introduction

People often consume alcohol following trauma, particularly in response to distressing memories. To date, little is known about how post-encoding alcohol consumption influences episodic memory recall for negative events. Understanding these effects may help to improve support for trauma victims – for example, witnesses and victims of crimes.

Methods

We tested 60 participants who self-described as heavy drinkers. After watching an analog trauma film, half were allocated to consuming a moderate dose of alcohol (Alcohol-Exposed group), while half received a placebo drink (Placebo-Control group). Immediately and after a one-week delay, participants recalled the eventviafree and cued recall tasks. Participants also gave remember-know responses and confidence ratings, elucidating alcohol’s effect on experiential memory.

Results

Free recall performance was similar for the Alcohol-Exposed group and the Placebo-Control group during Sessions 1 and 2. The Alcohol-Exposed group benefitted more from the delayed repeated retrieval attempt. For the cued recall task, the Alcohol-Exposed group provided more “Do not Know” responses compared to the Placebo-Control group in both sessions. For the Alcohol-Exposed group only “Correct Know” responses increased from Session 1 to 2. Although memory performance improved across sessions, confidence levels decreased from Session 1 to 2 in the Alcohol-Exposed group.

Discussion

Post-encoding alcohol consumption appears to impact immediate episodic memory retrieval; however, this effect is only temporary in nature. No evidence was found that alcohol primarily reduces remembering responses. Much like previous findings focusing on pre-encoding alcohol consumption (Hagsand et al., 2017), current findings suggest that providing individuals who drank alcohol after witnessing an incident with a delayed repeated retrieval attempt can lead to more complete and accurate testimonies.
Authoritative parenting style positively correlates with increased adherence to COVID-19 health and safety guidelines by college students
Authors: Spivey Adrienne J. , Bodily Jessica Stagner
Published: March 2023

During the COVID-19 pandemic, there has been inconsistency in choice behavior across people with regards to compliance with health and safety guidelines suggested by the CDC. The current study aimed to identify a possible correlation between parenting style experienced during childhood and opinions/actions regarding CDC COVID-19 health guidance. College students were given a self-report survey aimed to measure childhood experience, parent–child relationship, and COVID-19 pandemic behavior. Participants that identified with Authoritarian parenting scored higher on the COVID Behavior measure, indicating a higher degree of compliance compared to participants that identified with Authoritative parenting. Additionally, gender and race category differences on the COVID Behavior measure were observed. Specifically, African American/Black participants scored higher than White or Other race identifying participants on the COVID Behavior measure. Lastly, females identifying as African American/Black or Other race scored higher than males identifying as African American/Black or Other race on the COVID Behavior measure. These findings begin to illuminate some of the variables that might play a role in choice behavior with regard to compliance to health guidelines. Further investigation into these variables could inform us about what plays a role in choice behavior and how better to integrate this knowledge when messaging the public about health guidelines.
An intervention study on a hospital-community integrated management model of tobacco dependence based on a community intervention trial
Authors: Qiao Kun , Liu Han , Li Xingming , Jin Qianying , Wang Yao , Gu Mingyu , Bai Xinyuan , Qin Tingting , Yang Yutong
Published: March 2023

Objective

To assess the effect of the hospital-community integrated management model of tobacco dependence on smoking cessation among community residents compared with a brief smoking cessation intervention.

Methods

Our study recruited 651 smokers who were willing to quit in 19 communities in Beijing and conducted a 6-month smoking cessation intervention. The control group receiving a brief smoking cessation intervention and the pilot group receiving an integrated smoking cessation intervention. Intention-to-treat analysis (ITT) and generalized estimating equations were used to assess the effects of the integrated intervention and smoking cessation medication on average number of cigarettes smoked per day (ACSD) and smoking cessation rate.

Results

Simple effects analysis showed that smokers taking medication had significantly lower ACSD than those not taking medication at follow-up, the control group reduced smoking by 3.270, 4.830, and 4.760 cigarettes in the first, third and sixth months, respectively, while the pilot group reduced by 6.230, 5.820, and 4.100 cigarettes. The integrated intervention significantly reduced ACSD among medication-taking smokers at 1st month (reduced by 3.420, P < 0.05) and 3rd month (reduced by 2.050, P < 0.05), but had no significant effect among non-medication taking smokers. The 3rd month smoking cessation rate among medication-taking smokers was 27.0%, which was significantly higher than the smokers with brief smoking cessation intervention.

Conclusion

The integrated hospital-community intervention can significantly promote smoking cessation among smokers taking medication, but the issue of payment for medication and additional labor compensation for medical staff should be addressed before its popularization.
Synthetic cannabinoids awareness among patients with opioid use disorder in Serbia – A survey based cross-sectional pilot study
Authors: Mijatović Jovin Vesna , Dickov Isidora , Ratković Dragana , Dickov Aleksandra , Tomas Ana
Published: March 2023

Introduction

There is limited data on the awareness and use of synthetic cannabinoids (SCs) in high-risk population in Serbia, despite SCs becoming more and more common at illicit drug market.

Aim

This pilot study aimed to examine the awareness and prevalence of use of SCs in patients with an opioid-use disorder and to identify patient characteristics and other factors associated with SCs use.

Patients and methods

This cross-sectional study was conducted at the Clinic for Psychiatry, Clinical Center Vojvodina, Serbia, the largest tertiary health care institution in this region of the country. All patients hospitalized due to the treatment of opioid dependence during November and December 2017 were included (response rate 100%), and filled-out an anonymous questionnaire specifically developed for the purpose of this study. Differences between patients reporting SCs use and those who did not were compared using chi-square test with values of p < 0.05 were considered significant.

Results

Out of 64 patients (median age 36.37 years), one third (32.81%) reported using SCs. Socio-demographic characteristics of the subjects were not associated with SCs use. There were differences in the most common sources of information reported between the SCs users and non-users. Majority of SCs users (76.0%) were informed about SCs through friends, compared with just 26.0% of non-users (<0.001). Nearly all study participants (93.8%) were daily tobacco users. The share of respondents reporting alcohol and marihuana use was significantly higher among the SCs users (52.0% vs. 20.9%, p = 0.011 and 15.6% vs. 12.5%, p = 0.015), respectively. Higher share of SCs users used multiple psychoactive substances (38.1% vs. 16.3%), and this difference was statistically significant (p = 0.047). The most commonly reported adverse effect of SCs among users included dry mouth (81.0%), trouble thinking clearly (52.4%) and panic attacks (52.4%).

Conclusion

Understanding the awareness and use of SCs among high-risk drug users, as well as associated factors can help improve substance-use disorder treatment in our setting. Educational activities targeting public are urgently needed to raise awareness on SCs, considering that social contacts are the main sources of information on SC for this vulnerable population. Users of SCs have also reported using other psychoactive substances more often, and this calls for a holistic approach addressing multiple factors to improve substance-use treatment in our setting.
Engaging physicians and nurses in balanced scorecard evaluation—An implication at Palestinian hospitals and recommendations for policy makers
Authors: Amer Faten , Kurnianto Arie Arizandi , Alkaiyat Abdulsalam , Endrei Dóra , Boncz Imre
Published: March 2023

Introduction

Healthcare workers (HCWs) are seldom involved in balanced scorecard (BSC) deployments. This study aims to incorporate Palestinian HCWs in the BSC to create health policy recommendations and action plans using BSC-HCW1, a survey designed and validated based on BSC dimensions.

Methodology

In this cross-sectional study, the BSC-HCW1 survey was delivered to HCWs in 14 hospitals from January to October 2021 to get them involved in PE. The differences between physicians' and nurses' evaluations were assessed by the Mann–Whitney U-test. The causal relationships between factors were analyzed using multiple linear regression. The multicollinearity of the model was checked. Path analysis was performed to understand the BSC strategic maps based on the Palestinian HCWs' evaluations.

Results

Out of 800 surveys, 454 (57%) were retrieved. No evaluation differences between physicians and nurses were found. The BSC-HCW1 model explains 22–35% of HCW loyalty attitudes, managerial trust, and perceived patient trust and respect. HCWs' workload time-life balance, quality and development initiatives, and managerial performance evaluation have a direct effect on improving HCWs' loyalty attitudes (β = 0.272, P < 0.001; β = 0.231, P < 0.001; β = 0.199, P < 0.001, respectively). HCWs' engagement, managerial performance evaluation, and loyalty attitudes have a direct effect on enhancing HCWs' respect toward managers (β = 0.260, P < 0.001; β = 0.191, P = 0.001; β = 0.135, P = 0.010, respectively). Quality and development initiatives, HCWs' loyalty attitudes, and workload time-life balance had a direct effect on improving perceived patient respect toward HCWs (β = 254, P < 0.001; β = 0.137, P = 0.006, β = 0.137, P = 0.006, respectively).

Conclusion

This research shows that it is important to improve low-performing indicators, such as the duration of time HCWs spend with patients, their knowledge of medications and diseases, the quality of hospital equipment and maintenance, and the inclusion of strengths and weaknesses in HCWs' evaluations, so that HCWs are more loyal and less likely to want to leave. For Palestinian hospital managers to be respected more, they must include HCWs in their action plans and explain their evaluation criteria. Patients will respect Palestinian HCWs more if they prioritize their education and work quality, spend more time with patients, and reflect more loyalty. The results can be generalized since it encompassed 30% of Palestinian hospitals from all categories.
Investigating metformin-active substances from different manufacturing sources by NIR, NMR, high-resolution LC-MS, and chemometric analysis for the prospective classification of legal medicines
Authors: Raimondo Mariangela , Prestinaci Francesca , Aureli Federica , D’Ettorre Giulia , Gaudiano Maria Cristina
Published: March 2023

Introduction: The characterisation of active substances is an essential tool to ensure the traceability and authenticity of legal medicines. Metformin is a well-established biguanide derivative recommended in oral formulations as a first-line treatment for type 2 diabetes. With its increasing demand, metformin is likely to be an attractive target for falsification and substandard production, thus posing health risks to consumers. Methods that are able to identify even small differences in active pharmaceutical ingredients (APIs) are deemed necessary. The detection of fraudulent practices in APIs is not straightforward, and a single technique that can provide sufficient information to unambiguously address this issue is still not available.

Methods: This study investigated an integrated analytical platform based on NIR, 1H-NMR, 13C-NMR, and high-resolution LC-MS combined with chemometrics to profile 32 metformin hydrochloride samples originating from several global authorised manufacturers. The study's aim was to explore differences in the chemical characteristics of metformin hydrochloride APIs to identify or predict a possible classification for each manufacturer in view of prospective authenticity studies. Different pre-processing methods were applied; bucket tables for 1H- and 13C-NMR were obtained, while mass spectrometry data were processed in targeted and untargeted modes. Datasets were individually analysed and merged by a multivariate unsupervised method and performing principal component analysis (PCA).

Results and Discussion: The results evidenced differences in cluster behaviour, depending on manufacturers. Each technique has shown a specific clustering tendency, highlighting how different analytical approaches are able to characterise metformin APIs. Some manufacturers’ samples, however, showed similar behaviour independently of the techniques. NIR and 1H-NMR were confirmed as the more predictive techniques if taken individually; 1H-NMR, in particular, achieved good separation between the samples of the two most representative manufacturers. For LC-MS, the targeted approach resulted in a separation in groups clearer than that of the untargeted approach. Nevertheless, the untargeted LC-MS approaches presented in this paper could be a possible alternative to obtaining different information for drug substances, with several different and complex synthetic pathways leading to several unknown impurities. Further grouping of manufacturers emerged by data fusion, highlighting its potential in the traceability of metformin.
Repeated measures of implementation variables
Authors: Fixsen Dean L. , Van Dyke Melissa K. , Blase Karen A.
Published: March 2023

It is commonly acknowledged that implementation work is long-term and contextual in nature and often takes years to accomplish. Repeated measures are needed to study the trajectory of implementation variables over time. To be useful in typical practice settings, measures that are relevant, sensitive, consequential, and practical are needed to inform planning and action. If implementation independent variables and implementation dependent variables are to contribute to a science of implementation, then measures that meet these criteria must be established. This exploratory review was undertaken to “see what is being done” to evaluate implementation variables and processes repeatedly in situations where achieving outcomes was the goal (i.e., more likely to be consequential). No judgement was made about the adequacy of the measure (e.g., psychometric properties) in the review. The search process resulted in 32 articles that met the criteria for a repeated measure of an implementation variable. 23 different implementation variables were the subject of repeated measures. The broad spectrum of implementation variables identified in the review included innovation fidelity, sustainability, organization change, and scaling along with training, implementation teams, and implementation fidelity. Given the long-term complexities involved in providing implementation supports to achieve the full and effective use of innovations, repeated measurements of relevant variables are needed to promote a more complete understanding of implementation processes and outcomes. Longitudinal studies employing repeated measures that are relevant, sensitive, consequential, and practical should become common if the complexities involved in implementation are to be understood.
Global research trends and hotspots analysis of hallux valgus: A bibliometric analysis from 2004 to 2021
Authors: Wang Shulong , Deng Ping , Sun Xiaojie , Han Jinglu , Yang Shanshan , Chen Zhaojun
Published: March 2023

Background

Hallux valgus (HV) is a common foot and ankle surgery disease. The correction of HV deformity relies on a highly challenging surgical treatment. Thus, widely adopted evidence-based clinical guidelines are still needed to guide the selection of the most appropriate interventions. Recently, the study of HV has been growing and scholars are increasingly paying particular attention to this area. However, bibliometric literature remains lacking. Therefore, this study aims to reveal the hotspots and future research trends in HV via bibliometric analysis to fill this knowledge gap.

Methods

Literature related to HV from 2004 to 2021 was retrieved from the Science Citation Index Expanded (SCI-expanded) of the Web of Science Core Collection (WoSCC). Quantitative and qualitative analyses of scientific data are performed using software such as CiteSpace, R-bibliometrix, and VOSviewer.

Results

A total of 1,904 records were identified for analysis. The United States had the most number of published articles and total citations. Thus, the United States has made an essential contribution to the field of HV. Meanwhile, La Trobe University in Australia was the most productive institution. Menz HB and Foot & Ankle International were the most influential authors and the most popular journals among researchers, respectively. In addition, “older people,” “chevron osteotomy,” “Lapidus,” and “hallux rigidus” have always been the hotspots of attention. Changes and developments in the surgery of HV have gained researchers' interest. Future research trends are more focused on “radiographic measurement,” “recurrence,” “outcome,” “rotation,” “pronation,” and “minimally invasive surgery.” Thus, focusing on these subject directions can facilitate academic progress and provide the possibility of better treatments for HV.

Conclusion

This study summarizes the hotspots and trends in the field of HV from 2004 to 2021, which will provide researchers with an updated view of essential information and somehow guide future research.
Psychological Empowerment and Job Performance: Examining Serial Mediation Effects of Self-Efficacy and Affective Commitment
Authors: Ochoa Pacheco Paola , Coello-Montecel David , Tello Michelle
Published: March 2023

A substantial body of literature has analyzed the influence of psychological empowerment on individual and organizational outcomes. However, there is still a need to examine how empowered employees achieve higher performance. To fill this gap in the literature, this study analyzed the mediating role of self-efficacy and affective commitment in the relationship between psychological empowerment and task-based job performance. Data were collected from 357 employees. The hypotheses were tested using structural equation modeling and bootstrapping procedures. The results validated the structural relationships between psychological empowerment, self-efficacy, affective commitment, and task-based job performance. In addition, the serial mediation effect of self-efficacy and affective commitment was also confirmed. These results highlight the relevance of psychological variables, such as psychological empowerment and affective commitment, for individuals and organizations. The study supports that feeling empowered and emotionally committed is essential in building a long-term relationship between the employee and the organization.
Black Bear Behavior and Movements Are Not Definitive Measures of Anthropogenic Food Use
Authors: Hardeman Don W. , Vander Zanden Hannah B. , McCown J. Walter , Scheick Brian K. , McCleery Robert A.
Published: March 2023

Increasing human–bear conflicts are a growing concern, and managers often assume bears in developed areas are food-conditioned. We examined the relationship between human–bear conflicts and food conditioning by analyzing isotopic values of hair from black bears (Ursus americanus floridanus) involved in research (n = 34) and conflicts (n = 45). We separated research bears into wild and developed subgroups based on the impervious surface within their home ranges and separated conflict bears based on observations of human food consumption (anthropogenic = observations; management = no observations). We initially assumed wild bears were not food conditioned and anthropogenic bears were. However, using isotopic values, we classified 79% of anthropogenic bears and 8% of wild bears as food conditioned. Next, we assigned these bears to the appropriate food conditioned category and used the categorizations as a training set to classify developed and management bears. We estimated that 53% of management bears and 20% of developed bears were food conditioned. Only 60% of bears captured within or using developed areas showed evidence of food conditioning. We also found that δ13C values were a better predictor of anthropogenic foods in a bear’s diet than δ15N values. Our results indicate that bears in developed areas are not necessarily food conditioned and caution against management actions based on limited observations of bear behavior.
Anatomical Description of Rhinoceros Iguana (Cyclura cornuta cornuta) Head by Computed Tomography, Magnetic Resonance Imaging and Gross-Sections
Authors: González Rodríguez Eligia , Encinoso Quintana Mario , Morales Bordon Daniel , Garcés José Guerra , Artiles Nuez Himar , Jaber José Raduan
Published: March 2023

In this paper, we attempted to elaborate on an atlas of the head of the rhinoceros iguana, applying modern imaging techniques such as CT and MRI. Furthermore, by combining the images acquired through these techniques with macroscopic anatomical sections, we obtained an adequate description of the relevant structures that form the head of this species. This anatomical information could provide a valuable diagnostic tool for the clinical evaluation of different pathological processes in iguanas such as abscesses and osteodystrophy secondary to nutrient imbalances, skull malformations, fractures, and neoplasia.
Giardia duodenalis Colonization Slightly Affects Gut Microbiota and Hematological Parameters in Clinically Healthy Dogs
Authors: Peruzzo Arianna , Vascellari Marta , Massaro Andrea , Mancin Marzia , Stefani Annalisa , Orsini Massimiliano , Danesi Patrizia , Petrin Sara , Carminato Antonio , Santoro Michele Matteo , Speranza Roberto , Losasso Carmen , Capelli Gioia
Published: March 2023

Giardia duodenalis (Giardia) is a worldwide cause of acute diarrheal disease both in humans and animals. The primary aim of this study was to investigate possible variations in gut microbiota in a population of asymptomatic dogs (n = 31), naturally infected or not by Giardia. Gut microbiota and the hematological, biochemical, and fecal parameters related to intestinal function were investigated. Giardia infection was associated with a significant shift of beta diversity, showing a relevant reduction of Gammaproteobacteria and an increase of Fusobacteria in male-positive dogs if compared with negatives. A significant imbalance of different bacterial taxa, with particular reference to the Erysipelotrichales, Lactobacillales, Clostridiales, and Burkholderiales orders, was observed, with the first two being higher in Giardia-positive dogs. Giardia-positive males displayed significantly higher values of cCRP than negative males as well as positive females, supporting the presence of a pro-inflammatory state. Taken together, these results indicate that the presence of Giardia does not substantially modify the microbial ecology of the intestine nor the hematological markers of disease. Thus treatments against Giardia should be considered with caution in asymptomatic subjects.
Effects of Soybean and Linseed Oils Calcium Salts and Starter Protein Content on Growth Performance, Immune Response, and Nitrogen Utilization Efficiency in Holstein Dairy Calves
Authors: Rajabi Ardashir , Fattahnia Farshid , Shamsollahi Mohammad , Jahani-Azizabadi Hossein , Khalilvandi-Behroozyar Hamed , Pezeshki Adel , Kazemi-Bonchenari Mehdi
Published: March 2023

This study aimed to investigate the interaction of fatty acid (FA) source [calcium salt of soybean oil (n-6 FA) vs. calcium salt of linseed oil (n-3 FA) both 3% DM basis] with protein content (18% vs. 22% CP, based on DM) on growth performance, blood metabolites, immune function, skeletal growth indices, urinary purine derivatives (PD), and microbial protein synthesis (MPS) in young dairy calves. Forty 3-day-old calves (20 females and 20 males) with a starting body weight (BW) of 40.2 kg were assigned in a completely randomized block design in a 2 × 2 factorial arrangement of treatments. Experimental diets were: (1) n-6 FA with 18% CP (n-6-18CP), (2) n-6 FA with 22% CP (n-6-22CP), (3) n-3 FA with 18% CP (n-3-18CP), and (4) n-3 FA with 22% CP (n-3-22CP). Starter feed intake and average daily gain (ADG) were not influenced by experimental diets (p > 0.05). However, before weaning and the entire period, feed efficiency (FE) was greater in calves fed n-3 FA compared to n-6 FA (p < 0.05). Heart girth (weaning, p < 0.05) and hip height (weaning, p < 0.05 and final, p < 0.01) were highest among experimental treatments in calves who received n-3-22CP diets. The greatest blood glucose (p < 0.05) and insulin (p < 0.01) concentrations in the pre-weaning period and the lowest serum concentration of tumor necrosis factor (before weaning, p < 0.05) were observed in calves fed the n-3-22CP diet. However, the greatest blood urea N (before weaning, p < 0.05; after weaning, p < 0.05) and urinary N excretion (p < 0.05) were found in calves fed n-6-22CP diets compared to other experimental arrangements. In conclusion, offering calves with Ca-salt of n-3 FA along with 22% CP content may be related to improved nitrogen efficiency and immune function.
How Sanctuary Chimpanzees (Pan troglodytes) Use Space after Being Introduced to a Large Outdoor Habitat
Authors: Fultz Amy , Yanagi Akie , Breaux Sarah , Beaupre Leilani , Naitove Nick
Published: March 2023

Wild chimpanzees live in large, mixed-sex groups that display a fission–fusion social organization. To provide a social environment more like that of wild chimpanzees, Chimp Haven integrated smaller groups of 3–4 individuals into one large group of 18 individuals. This large group was introduced to a 20,234.28 m2 forested habitat and associated indoor areas. This space was designed to allow the individual chimpanzees to choose their proximity to social companions and provide the group with a more natural environment in which they could express more species-typical behavior. The study took place over a 7-month period that began two weeks prior to the first groups being integrated and ended 4 months after the chimpanzees were released into the habitat. We collected data on the chimpanzees’ arboreal, terrestrial, indoor, and outdoor spatial use. The chimpanzees’ proximity to their nearest neighbor was also recorded, noting whether they were touching or within arm’s reach. Data were collected during daytime and nighttime hours and were utilized to make management decisions about potential group formations. We examined the data using generalized linear mixed models (GLMMs) with individual subjects as a random factor and months as a repeated measure for location and proximity results. There were significant differences in the use of arboreal and outside space over the 7-month time frame, with females more likely to use the arboreal space than males. The chimpanzees were more likely to utilize the habitat over time and increased their proximity to group mates. The results of this study indicate that the chimpanzees responded positively to living in large groups in a spacious naturalistic environment.
Estimation, Evaluation and Characterization of Carbapenem Resistance Burden from a Tertiary Care Hospital, Pakistan
Authors: Gondal Aamir Jamal , Choudhry Nakhshab , Bukhari Hina , Rizvi Zainab , Jahan Shah , Yasmin Nighat
Published: March 2023

Carbapenem resistance has become major concern in healthcare settings globally; therefore, its monitoring is crucial for intervention efforts to halt resistance spread. During May 2019–April 2022, 2170 clinical strains were characterized for antimicrobial susceptibility, resistance genes, replicon and sequence types. Overall, 42.1% isolates were carbapenem-resistant, and significantly associated with Klebsiella pneumoniae (K. pneumoniae) (p = 0.008) and Proteus species (p = 0.043). Carbapenemases were detected in 82.2% of isolates, with blaNDM-1 (41.1%) associated with the ICU (p < 0.001), cardiology (p = 0.042), pediatric medicine (p = 0.013) and wound samples (p = 0.041); blaOXA-48 (32.6%) was associated with the ICU (p < 0.001), cardiology (p = 0.008), pediatric medicine (p < 0.001), general surgery (p = 0.001), general medicine (p = 0.005) and nephrology (p = 0.020); blaKPC-2 (5.5%) was associated with general surgery (p = 0.029); blaNDM-1/blaOXA-48 (11.4%) was associated with general surgery (p < 0.001), and wound (p = 0.002), urine (p = 0.003) and blood (p = 0.012) samples; blaOXA-48/blaVIM (3.1%) was associated with nephrology (p < 0.001) and urine samples (p < 0.001). Other detected carbapenemases were blaVIM (3.0%), blaIMP (2.7%), blaOXA-48/blaIMP (0.1%) and blaVIM/blaIMP (0.3%). Sequence type (ST)147 (39.7%) represented the most common sequence type identified among K. pneumoniae, along with ST11 (23.0%), ST14 (15.4%), ST258 (10.9%) and ST340 (9.6%) while ST405 comprised 34.5% of Escherichia coli (E. coli) isolates followed by ST131 (21.2%), ST101 (19.7%), ST10 (16.0%) and ST69 (7.4%). Plasmid replicon types IncFII, IncA/C, IncN, IncL/M, IncFIIA and IncFIIK were observed. This is first report describing the carbapenem-resistance burden and emergence of blaKPC-2-ST147, blaNDM-1-ST340 and blaNDM-1-ST14 in K. pneumoniae isolates and blaNDM-1-ST69 and blaNDM-1/blaOXA-48-ST69 in E. coli isolates coharboring extended-spectrum beta-lactamases (ESBLs) from Pakistan.
Nurses’ Knowledge, Attitudes and Practices on the Management of Clostridioides difficile Infection: A Cross-Sectional Study
Authors: Comparcini Dania , Simonetti Valentina , Segala Francesco Vladimiro , Di Gennaro Francesco , Bavaro Davide Fiore , Pompeo Maria Antonietta , Saracino Annalisa , Cicolini Giancarlo
Published: March 2023

Clostridioides difficile is, worldwide, the leading cause of hospital-acquired infection. Outbreaks are largely related to antibiotic exposure and contact contamination, but little is known about C. difficle infection (CDI) awareness in the nurse population. We conducted a cross-sectional survey to study Italian nurses, based on CDI guidelines. We recruited 200 nurses working in 14 Italian hospitals. Using a one-way analysis of variance of knowledge scores, female nurses (mean 9.67 (standard deviation ± 1.63), p = 0.03), and nurses with a higher level of university education (mean 9.79 (SD ± 1.67), p = 0.04) were demonstrated to have better knowledge about CDI. In addition, 92.5% (n = 184) of the sample declared that they did not have specific postgraduate training about CDI. Seventy-four percent (n = 149) of the respondents declared that they used procedures, protocols and guidelines about CDI in their workplace, but only 46.5% (n = 93) reported using C. difficile-specific bundles during their daily practice. In conclusion, our study highlights a lack of knowledge concerning CDI clinical guidelines among Italian nurses.
Voice Interaction Recognition Design in Real-Life Scenario Mobile Robot Applications
Authors: Li Shih-An , Liu Yu-Ying , Chen Yun-Chien , Feng Hsuan-Ming , Shen Pi-Kang , Wu Yu-Che
Published: March 2023

This paper designed a voice interactive robot system that can conveniently execute assigned service tasks in real-life scenarios. It is equipped without a microphone where users can control the robot with spoken commands; the voice commands are then recognized by a well-trained deep neural network model of automatic speech recognition (ASR), which enables the robot to execute and complete the command based on the navigation of a real-time simultaneous localization and mapping (SLAM) algorithm. The voice interaction recognition model is divided into two parts: (1) speaker separation and (2) ASR. The speaker separation is applied by a deep-learning system consisting of eight convolution layers, one LSTM layer, and two fully connected (FC) layers to separate the speaker’s voice. This model recognizes the speaker’s voice as a referrer that separates and holds the required voiceprint and removes noises from other people’s voiceprints. Its automatic speech recognition uses the novel sandwich-type conformer model with a stack of three layers, and combines convolution and self-attention to capture short-term and long-term interactions. Specifically, it contains a multi-head self-attention module to directly convert the voice data into text for command realization. The RGB-D vision-based camera uses a real-time appearance-based mapping algorithm to create the environment map and replace the localization with a visional odometer to allow the robot to navigate itself. Finally, the proposed ASR model was tested to check if the desired results will be obtained. Performance analysis was applied to determine the robot’s environment isolation and voice recognition abilities. The results showed that the practical robot system successfully completed the interactive service tasks in a real environment. This experiment demonstrates the outstanding performance with other ASR methods and voice control mobile robot systems. It also verified that the designed voice interaction recognition system enables the mobile robot to execute tasks in real-time, showing that it is a convenient way to complete the assigned service applications.