bluuebunny/crossref_metadata_2025 huggingface dataset:
Legal issues on Conditional Consents of Korea’s Central Land tribunals on project approval under the Land Compensation Act
Authors:   Wonkwang University Legal Research Institute has, Rhee Vian
Published: April 2023

On February 24, 2002, the National Assembly integrated ‘the Land Expropriation Act’ and ‘the Special Act on the Compensation for Loss of Public Land’ and enacted ‘the Act On Acquisition Of And Compensation For Land For Public Works Projects (“the Land Compensation Act: LCA”).’ Nevertheless, the LCA was criticized for not protecting individual property rights because (quasi-)project approval was not able to guarantee ‘public needs.’ As a result, the LCA was amended in 2015 and 2018. The Minister of Land, Infrastructure and Transport(“LIT Minister”) and authorities of quasi-project approval should have a consultation with Central Land Tribunal(“CLT”) during (quasi-)project approval procedures. However, several unexpected problems began to arise, particularly when CLT gives a conditional consent for quasi-project approval after consultation. A conditional consent for quasi-project approval requires a public project operator to achieve much more (which is 75 percent than than 50 percent of public project area which is required as consultation acquisition rate. The proviso of a conditional consent allows a public project operator to apply for CLT hearing. Some local land tribunals (“LLTs”) intend to establish administrative rules for excessive compensation demands. However, LLTs are not authorized to make those rules. And those rules are directly against the landowners who are subject to taking. LLTs may make an adjudication of the Land Tribunal only on cases in which 75 percent consultation acquisition rate has been achieved. If the rate was not met at the time of application but was achieved during LLTs’s process, LLTs should make an adjudication to dismiss. If not, applying for land expropriation could be used as a means of threatening landowners to consult. However, landowners could request a public project operator to apply for adjudication of the Land Tribunal, regardless of whether or not the acquisition rate is achieved.
Imago mundi: consciência de globalidade e cosmografia medieval
Authors: Dias da Silveira Aline
Published: April 2023

O presente artigo tem como objetivo trazer o conceito de consciência de globalidade para a análise de culturas pré-modernas, tendo como objeto de estudo as crônicas cosmográficas medievais, tipificadas por Anne-Dorothee von den Brincken (1969), como imago mundi. Serão trazidos para a análise trechos da imago mundi do Atlas Catalão (1375) e do Libro de las Cruzes (1961/1259), com foco nesse último. A considerar a definição de consciência de globalidade de Roland Robertson (1999) como a percepção da conectividade e interdependência entre as partes e o todo, pretende-se evidenciar como, historicamente, essa compreensão do mundo foi experimentada e manifesta nesse tipo de fonte. Como metodologia, aplica-se a análise hermenêutica da fonte – no sentido de entendê-la em sua racionalidade própria – em relação com a interpretação heurística. Por essa via, serão também apontadas algumas contribuições que o conceito consciência de globalidade traz à perspectiva de história global e a compreensão da cosmovisão medieval manifesta na fonte.
Na Zona...: representações da prostituição na belle époque carioca a partir de conto pornográfico (1914)
Authors: Cardoso Erika Natasha
Published: April 2023

O jornal carioca O Rio Nu (1898-1916), mais ilustre e longevo representante de um gênero periódico que no Brasil ficaria conhecido como “jornais alegres”, dedicou-se à edição de leituras para homens, como eram conhecidos os romances pornográficos no país. Este artigo tem como objetivo analisar o conto Na Zona..., publicado em formato de livro pelo jornal em 1914, como parte da “Coleção Contos Rápidos”. Ambientado no Rio de Janeiro, o enredo acompanha as aventuras de um homem que percorre as ruas do centro da cidade em busca de sexo. Um dos poucos renascentes da literatura pornográfica produzida no Brasil durante esse período, Na Zona... nos permite refletir em torno das representações da prostituição exercida no Rio de Janeiro durante o limiar do século XX.
On the Diophantine Equation 15x – 13y = z2
Authors: Thongnak Sutthiwat , Chuayjan Wariam , Kaewong Theeradach
Published: April 2023

In this article, we prove that the Diophantine equation 15x – 13y = z2 has nonnegative integer solution. The result reveals that the solution (x, y, z) = (0, 0, 0). Keywords: Diophantine equation; factoring method; modular arithmetic method
How the Rule of Law Connects and Protects Human Rights?
Authors: Xu Dongxiao
Published: April 2023

The rule of law has become an important fundamental framework for government governance; it helps promote justice, fairness, and individual freedom, which are some rights that are included within the scope of human rights. Nowadays, the rule of law has been regarded as the most effective way to protect human rights, therefore, how the rule of law connects and protects human rights is a discussible issue. This essay will focus on the principles given by Professor Evan Fox-Decent, discuss the connection between the rule of law and human rights protection, and discuss how the rule of law can protect human rights.
Administrative Regulation of Social Media Algorithms in the European Union and America and Their Implications for China
Authors: Cai Ting-ting
Published: April 2023

While social media algorithms have brought positive effects, they have also brought a series of crises that have sparked public concern about algorithmic technology. In response, many countries have adopted a series of regulations on platform algorithms. The EU mainly adopts a collaborative regulatory model between administrative agencies and private institutions, emphasizing both ex-ante and ex-post regulation of algorithms, and further reinforcing the obligations and responsibilities of social media platforms, as well as adopting focused regulation on large social media platforms. The U.S. mainly focuses on external accountability, industry self-regulation, and the protection of freedom of expression and democratic politics. By analyzing the dynamics and practices of administrative regulation of social media algorithms in the EU and the U.S., it is suggested that China should: build a multiple regulation model, realize the substantial participation of other subjects, explore the hierarchical and categorical regulation of social media platforms, strengthen the construction of anti-monopoly for large social media platforms, and enhance the whole process regulation of social media algorithms, with a belief of building a perfect social media algorithm regulation system.
A Short Note on Two Diophantine Equations 9 x – 3y = z2 and 13x – 7y = z2
Authors: Tadee Suton
Published: April 2023

In this short note, we show that the Diophantine equation 2 9 3 x y − = z has all non-negative integer solutions , , ∈ { , 2 , 0 : ∈ ℕ ∪ {0}} and the Diophantine equation 2 13 7 x y − = z have the unique non-negative integer solution ( , , ) (0,0,0) x y z = .
Design of capacitor-less LDO regulator for low-voltage applications
Authors: Kwon Sang wook , koo yong seo
Published: April 2023

The capacitor-less low dropout voltage regulator applied to mobile
devices increases the power consumption due to the continuously exposed
peak voltage. The dynamic feedback loop for the LDO regulator proposed
in this study can provide a function to stably control the peak voltage
regardless of the change in the load current.
Design of capacitor-less LDO regulator with high reliability ESD Protection circuit using analog switch structure for 5 V applications
Authors: Kwon Sang wook , koo yong seo
Published: April 2023

This letter suggests to the LDO regulator with the high reliability ESD
protection circuit that achieves low peak voltage through analog switch
structure. The proposed LDO regulator has the function of detecting the
output voltage fluctuations depending on the load via an analog switch
structure and effectively controlling the peak voltage.
Morphological overdispersion supports the role of competition in the community assembly of dragonflies: drivers and spatio-seasonal variation
Authors: Novella-Fernandez Roberto , Chalmandrier Loïc , Brandl Roland , Pinkert Stefan , Zeuss Dirk , Hof Christian
Published: April 2023

Our understanding of how biotic interactions influence animal community
assembly is largely restricted to local systems due to the difficulty of
obtaining ecologically meaningful assemblage data across large spatial
extents. We used a unique dataset of thousands of spatio-phenologically
high-resolution assemblages across three distinct European regions
together with a functional diversity approach to understand community
assembly of dragonflies and damselflies (Odonata), a group characterized
by a pronounced competitive reproductive biology. We found that
dragonfly, but not damselfly, assemblages were consistently
overdispersed in the morphological traits driving inter-specific
reproductive encounters, which supports the role of competition. As
predicted by ecological theory, support for competition varied spatially
and seasonally as a result of changes in temperature stress and niche
packing. Our study provides uniquely consistent and general evidence for
the role of competition in animal community assembly, and illustrates
mechanistically how spatio-temporal diversity patterns arise from
variation in assembly processes.
LEKTI domain 6 displays anti-inflammatory action in vitro and in a murine atopic dermatitis model
Authors: Bäumer Wolfgang , Canbolat Pascal , Wilzopolski Jenny , Kaessmeyer Sabine , Rüger Marc , Mägert Hans-Jürgen , Forssmann Wolf-Georg
Published: April 2023

Background: Lympho-epithelial Kazal-type-related inhibitor (LEKTI) is a
serine protease inhibitor consisting of multiple domains. A loss of
function mutation is described in Netherton patients that show severe
symptoms of atopic lesions and itch. Objectives: LEKTI domain 6 (LD6)
has shown strong serine protease-inhibitory action in in vitro
assays and thus it was tested in vitro and in vivo for
potential anti-inflammatory action in models of atopic skin disease.
Methods: Human skin equivalents were treated with LD6 and an
inflammatory reaction was challenged by kallikrein-related endopeptidase
5 (KLK5). Furthermore, LD6 was tested on dorsal root ganglia cells
stimulated with KLK5, SLIGRL and histamine by calcium imaging. The
effect of topically administered LD6 (0.4–0.8 %) in lipoderm was
compared to a topical formulation of betamethasone-diproprionate (0.5
%) in a therapeutic setting on atopic dermatitis-like lesions in NC/Nga
mice sensitized to house dust mite antigen. Endpoints were clinical
scoring of the mice as well as determination of scratching behaviour.
Results: KLK5 induced an upregulation of CXCL-8, CCL20 and IL-6 in skin
equivalents. This upregulation was reduced by pre-incubation with LD6.
KLK5 as well as histamine induced calcium influx in a population of
neurons. LD6 significantly reduced the calcium response to both stimuli.
When administered onto lesional skin of NC/Nga mice, both LD6 and
betamethasone-dipropionate significantly reduced the inflammatory
reaction. The effect on itch behaviour was less pronounced. Conclusions:
Topical administration of LD6 might be new therapeutic option for
treatment of lesional atopic skin.
Improved Multimer Prediction using Massive Sampling with AlphaFold in CASP15
Authors: Wallner Björn
Published: April 2023

AlphaFold has transformed structure prediction by enabling highly
accurate predictions on par with experimentally determined structures.
Still, for difficult cases, in particular, multimers, there is still
room for improvement. Important for the success of AlphaFold is its
ability to assess its own predictions. The basic idea for the Wallner
group in CASP15 was to exploit the excellent ranking score in AlphaFold
by massive sampling. To this end, we ran AlphaFold using six different
settings, with and without templates, and with an increased number of
recycles using both multimer v1 and v2 weights. In all cases, the
dropout layers were enabled at inference to sample the uncertainty and
increase the diversity of the generated models. A median of 4,810 models
per target was generated and almost all (35/38) received a
ranking_confidence >0.7. Compared to other groups
in CASP15, Wallner obtained the highest sum of Z-scores based on the
DockQ score, 40.8 compared to 26.3 for the second highest, much higher
than -0.2 achieved by the AlphaFold baseline method, NBIS-AF2-multimer.
The improvement over the baseline is substantial with the mean DockQ
increasing from 0.43 to 0.56, with several targets showing a DockQ score
increase by +0.6 units. Remarkable, considering Wallner and
NBIS-AF2-multimer were using identical input data. The reason for the
success can be attributed to the diversified sampling using dropout with
different settings and, in particular, the use of multimer v1, which
seems to be much more susceptible to sampling compared to v2. The method
is available here: http://wallnerlab.org/AFsample/.
GeneMiner: a tool for extracting phylogenetic markers from next-generation sequencing data
Authors: Xie Pulin , Guo Yongling , Zhou Wenbin , Zhang Zhen , Yu Yan
Published: April 2023

The advancement of Next-generation Sequencing (NGS) technologies has led
to a revolution in the field of evolutionary biology. With the
increasing number of available genomes and transcriptomes, researchers
can mine various types of molecular markers that are vital for
phylogenetic, evolutionary, and ecological studies. Numerous tools have
been developed to extract these molecular markers from NGS data.
However, due to a limited number of well-annotated reference genomes for
non-model organisms, it is still challenging to obtain these markers
accurately and efficiently. Here, we present GeneMiner, an improved and
expanded version of our previous tool, Easy353. GeneMiner involves the
reference-guided de Bruijn Graph assembly with seed self-discovery and
greedy extension. Additionally, it includes a verification step using a
parameter-bootstrap method to reduce the negative impact on assembly
caused by the relatively distant reference. Our results using both
experimental and simulation data showed GeneMiner can accurately acquire
phylogenetic molecular markers for plants using transcriptomic, genomic,
and other NGS data. GeneMiner is designed to be user-friendly, fast, and
memory-efficient, and is compatible with Linux, Windows, and macOS. All
source codes are publicly available on GitHub for easy accessibility and
transparency (https://github.com/happywithxpl/GeneMiner).
Association of Medication Adherence With HbA1c Control Among American Indian Adults With Type 2 Diabetes Using Tribal Health Services
Authors: Scarton Lisa , Nelson Tarah , Yao Yingwei , DeVaughan-Circles Ashley , Legaspi Anatolia B. , Donahoo William T. , Segal Richard , Goins R. Turner , Manson Spero M. , Wilkie Diana J.
Published: April 2023

OBJECTIVE

To examine HbA1c levels and adherence to oral glucose-lowering medications and their association with future HbA1c levels among American Indian adults with type 2 diabetes (T2D) receiving medications at no cost from a tribal health care system.

RESEARCH DESIGN AND METHODS

Tribal citizens with T2D who used Choctaw Nation Health Services Authority (CNHSA) and Pharmacies and had HbA1c data during 2017–2018 were included in this study. Medication adherence (proportion of days covered [PDC] ≥0.80) was calculated using 2017 CNHSA electronic health record data.

RESULTS

Of the 74,000 tribal citizens living on tribal lands, 4,560 were eligible; 32% had HbA1c at or below target (≤7%), 36% were above target (>7 to ≤9%), and 32% were uncontrolled (>9%) in 2017. The percentage of patients with PDC ≥0.80 was 66% for those using biguanides, 72% for sulfonylureas, 75% for dipeptidyl peptidase 4 inhibitors, and 83% for sodium–glucose cotransporter 2 inhibitors. The proportion of patients with HbA1c at or below target increased slightly from 32% in 2017 to 42% in 2018. Higher average PDC in 2017 was associated with lower HbA1c levels in 2018 (β = −1.143; P < 0.001).

CONCLUSIONS

Medication adherence was higher than that found in previous studies using self-report methods in American Indian populations, although a smaller proportion of patients had HbA1c at or below target relative to U.S. adults with T2D. Medication adherence was associated with improved HbA1c levels for most oral glucose-lowering medication classes. Future studies of American Indians should use both longitudinal prescription data from both electronic health records and pharmacy refills.
The natural history of acetabular dysplasia and later total hip arthroplasty in late-detected DDH: 48 patients with closed reduction followed to a mean age of 62 years
Authors: Terjesen Terje
Published: April 2023

Background and purpose: The long-term prognosis of acetabular dysplasia without subluxation in developmental dislocation of the hip (DDH) is uncertain. The aim of this study was to assess the consequence of having acetabular dysplasia at skeletal maturity on the need for having a total hip arthroplasty (THA) up to the age of 60 years.Patients and methods: Inclusion criteria were age at diagnosis 0.5–3.0 years, initial treatment with skin traction to obtain closed reduction during 1958–1962, and no acetabular procedures to improve femoral head coverage. 48 patients (57 hips) met these criteria, 41 girls and 7 boys. Hip dysplasia was defined as a center–edge (CE) angle at skeletal maturity of 10–19°, and hips with CE angles in the range 20–25° were termed borderline dysplastic.Results: At skeletal maturity, 18 hips had acetabular dysplasia with a mean CE angle of 15.8° (10–19), whereas 19 hips were borderline with CE angles 20–25°, and 20 hips were normal (CE angles ≥ 26°). During the follow-up period 16 hips had undergone THA, 11 of 18 hips with dysplasia, 4 of 19 with borderline dysplasia, and 1 of 20 hips without dysplasia (p < 0.001). Hip survival in the 18 dysplastic hips, with THA as the endpoint, was 100% up to patient age 40 years; thereafter survival fell to 83% at 50 years and 39% at 60 years. There was no significant correlation between CE angle at skeletal maturity and age at THA (p = 0.2). The mean age at the last follow-up in patients without THA was 62 years (60–64).Conclusion: Acetabular dysplasia without subluxation was a risk factor for THA, but less than one-fifth of the hips had undergone THA up to patient age 50 years.
Formulation and Analysis of Alcohol Content in Pineapple Infused Arak Bali with Gas Chromatography
Authors: Ratih Gusti Ayu Made , Habibah Nur
Published: April 2023

Gastronomic drinks are one of the local cultures that have an important role in the development of the tourism world, one of which is Arak Bali. Various products of Arak Bali infused began to be developed to enrich the flavor. One of the potential ingredients to increase scent and flavor is pineapple. This study was conducted to determine the most popular formulation and the alcohol content of Pineapple Infused Arak Bali as a new safe gastronomic drink in accordance with government regulations. The type of research used True experimental with Posttest Only Control Group Design. The sample used was pineapple infused Arak Bali that was formulated into 5 concentration variations. Furthermore, the alcohol content analysis was carried out using Gas Chromatography method. Sample F4 was selected based on organoleptic tests from 30 panelists as the most popular formula. Analysis of alcohol content showed that both samples were negative for methanol while the ethanol content in FD (34.22%) was classified as group C liquor and FU (18.08%) was classified as group B in accordance with government regulations.
Quality of life in patients treated for COVID-19–associated mucormycosis at a tertiary care hospital
Authors: Kumar Pragya , Rao UR Rajath , Roy Nilanjan , Agrawal Deepika , Ahmad Shamshad , Bhavana Kranti
Published: April 2023

Objectives: Coronavirus disease 2019 (COVID-19)–associated mucormycosis (CAM) has emerged as a formidable infection in patients with COVID-19. The aggressive management of CAM affects quality of life (QOL); thus, this study was designed to assess the QOL in patients with CAM at a tertiary healthcare institution.Methods: This cross-sectional study of 57 patients with CAM was conducted over 6 months using a semi-structured standard questionnaire (the abbreviated World Health Organization Quality of Life questionnaire [WHO-BREF]) and a self-rated improvement (SRI) scale ranging from 0 to 9. Cut-off values of ≤52 and <7 were considered to indicate poor QOL and poor improvement, respectively. The correlations of QOL and SRI scores were evaluated using Spearman rho values.Results: In total, 27 patients (47.4%; 95% confidence interval [CI], 34.9%–60.1%) and 26 patients (45.6%; 95% CI, 33.4%–58.4%) had poor QOL and poor SRI scores, respectively. The overall median (interquartile range) QOL score was 52 (41–63). Headache (adjusted B, −12.3), localized facial puffiness (adjusted B , −16.4), facial discoloration (adjusted B, −23.4), loosening of teeth (adjusted B, −18.7), and facial palsy (adjusted B, −38.5) wer e significantly associated with the QOL score in patients with CAM.Conclusion: Approximately 1 in 2 patients with CAM had poor QOL and poor improvement. Various CAM symptoms were associated with QOL in these patients. Early recognition is the key to optimal treatment, improved outcomes, and improved QOL in patients with CAM.
Risk factors for deaths associated with COVID-19 according to the cause of death classification in Republic of Korea
Authors: Kim Na-Young , Kim Seong-Sun , Lee Hyun Ju , Kim Dong Hwi , Ryu Boyeong , Shin Eunjeong , Kwon Donghyok
Published: April 2023

Objectives: This study aimed to classify coronavirus disease 2019 (COVID-19)-related deaths according to whether COVID-19 was listed as the cause of death, and to investigate the differences in demographic characteristics and risk factors for COVID-19 death classifications.Methods: A total of 5,625 deaths in South Korea among patients with confirmed COVID-19 from January 20, 2020 to December 31, 2021 were selected. Excluding false reports and unnatural deaths, 5,597 deaths were analyzed. Based on death report data, deaths were classified according to whether the cause of death was listed as COVID-19 (CD) or not (NCD). The epidemiological characteristics and causes of deaths were investigated using descriptive, univariate, and multivariate statistical analyses. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to analyze the risk factors.Results: The case fatality ratio was 0.89% and increased with age. Additionally, 96.4% of the subjects had an underlying disease, and 53.4% died in winter. The proportion of NCDs was 9.3%, of whom 19.1% died at home and 39.0% were confirmed to have COVID-19 after death. Malignant neoplasms (102/416 vs. 637/4,442; OR, 1.71; 95% CI, 1.36−2.16; p<0.001) were significantly associated with NCD.Conclusion: This is the first study to analyze risk factors by cause of death using COVID-19 death report data in South Korea. These results are expected to be used as evidence for establishing a death monitoring system that can collect timely information in a new infectious disease pandemic.
Relaciones de género en la industria exportadora marroquí: Casablanca como caso de estudio
Authors:   Profesora sustituta interina, Departamento de Sociología, Trabajo Social y Salud Pública, Universidad de Huelva, Fajardo Fernández Rocío , Soriano-Miras Rosa M. ,   Profesora titular, Departamento de Sociología, Universidad de Granada, Trinidad Requena Antonio ,   Catedrático, Departamento de Sociología, Universidad de Granada
Published: April 2023

El objetivo de este artículo es analizar la forma en que las relaciones de género interactúan en la socialización laboral en la industria de exportación marroquí –a partir del estudio de caso de la ciudad de Casablanca– y su relación con la migración internacional. El diseño de la investigación es cualitativo, con un análisis desde la teoría fundamentada y una aproximación desde los estudios interseccionales. El mercado laboral global aparece como un nuevo eje de desigualdad que crea nuevos espacios, los cuales, aunque suponen una oportunidad para unas pocas personas, mantienen a una mayoría en situación de precariedad. La originalidad del artículo radica en la aplicación del marco teórico interseccional al contexto marroquí, centrándose en una visión relacional de las categorías. La identificación de tres procesos sociales básicos (rol de las mujeres, crisis de masculinidad y migración) nos permite ampliar el conocimiento sobre dicha realidad.
Open Government Index in Local Government During the Period of the COVID-19 Pandemic
Authors: Khairunnisa Tiara , Nurmandi Achmad , Purwaningsi Titin , Loilatu Mohammad Jafar , Savira Annisa Ghina
Published: April 2023

Identification that has been carried out in studies of open data government and e-government has been widely described from various perspectives. This study aims to examine how the government applies open government data. This study analyzed the existing open government of local government in Indonesia during the COVID-19 period, providing information to test the transparency of existing local governments. This study adopts the Benchmark Model Evaluating Data Openness theory and E-Gov assessment using a quantitative approach by dividing several categories and assessment variables. The open government analysis assessment uses a score of 1-5, and a web assessment with a score of 100. From this calculation, it is found that the five provinces with increased cases have high OGD scores. The results are plotted based on the spread of COVID-19 throughout Indonesia, as determined by reviewing and surveying the provincial government's COVID-19 website. West Java (89.87), East Java (89.87), Jakarta (88.75), Central Java (88.37), and Yogyakarta (88.37) all had high and nearly balanced total scores (84.87). The increased assessment results are supported by infrastructure and good management, and the five areas are "metropolitan" areas with good quality technology and information
Menjaga Keberlanjutan Produk Lokal dan Keuangan Keluarga: Peran Perempuan Sebagai Penganyam Bambu di Desa Sidetapa Buleleng Bali Utara
Authors: Widiastini Ni Made Ary , Rahmawati Putu Indah , Arsa I Ketut Sida
Published: April 2023

Penelitian ini bertujuan untuk mendeskripsikan peran perempuan sebagai penenun di Desa Sidetapa. Sejumlah perempuan penenun ditemui dalam penelitian ini untuk mengetahui mengapa mayoritas perempuan di Desa Sidetapa bekerja sebagai pengrajin bambu, jumlah produksi harian, jenis kerajinan bambu yang dihasilkan, dan sistem pemasaran produk kerajinan yang digunakan dalam memasarkan produknya. . Perempuan yang berprofesi sebagai pengrajin bambu menjadi subjek utama dalam penelitian ini. Observasi dan wawancara dilakukan secara langsung di Desa Sidetapa untuk mengumpulkan data-data yang dibutuhkan, kemudian dianalisis secara deskriptif kualitatif dengan menggunakan pendekatan kajian budaya. Dalam penelitian ini ditemukan bahwa mayoritas pengrajin bambu di Desa Sidetapa adalah perempuan, yang setiap hari selalu menekuni pekerjaannya setelah menyelesaikan pekerjaan rumah tangga. Ada juga yang menganyam setelah mengurus pertanian atau ternaknya. Pemasaran produk kerajinan bambu dilakukan dengan dua cara, yaitu melalui bantuan pengepul atau dengan menjual sendiri. Jika sudah memiliki pelanggan, maka penjualan produk akan dilakukan secara langsung. Namun, kebanyakan dari mereka mempercayai pengepul dalam menjual produknya. Dalam perkembangannya, produk kerajinan bambu di Desa Sidetapa banyak dipromosikan melalui media sosial, selain sebagai bentuk update terhadap perkembangan teknologi, juga memungkinkan penjualan menjangkau pasar yang lebih luas. Produk-produk tersebut masih memiliki kekurangan seperti hasil yang kurang halus dan mahal dibandingkan dengan produk sejenis lainnya yang ada di pasaran sehingga tidak dapat diterima. Sehingga pengrajin bambu , khususnya perempuan penganyam membutuhkan pendampingan dari aspek produksi untuk meningkatkan kualitas produk.
Relaciones y poder político alrededor de la figura de Julián Trujillo Largacha (1866-1883)
Authors: Acevedo Tarazona Álvaro , Villamizar Palacios Carlos Iván
Published: April 2023

Este artículo muestra cómo se construyen las sociabilidades alrededor del grupo político formado en torno al caudillo “liberal independiente” Julián Trujillo Largacha durante el periodo de los Estados Unidos de Colombia. A partir de la reconstrucción de los negocios e iniciativas intelectuales comunes, así como del análisis de su biografía, de documentos notariales, periódicos y, especialmente, a partir de los decretos de nombramiento expedidos entre 1861 y 1884 se evidencia la consolidación del grupo independiente gestado alrededor de la figura de Trujillo Largacha y que lleva, a su vez, a fortalecer el proyecto político de la Regeneración y a la finalización de la experiencia federal en la actual República de Colombia. La hipótesis de trabajo consiste en demostrar la paulatina creación de vínculos de sociabilidad política que desembocarán en una propuesta política alternativa al radicalismo entre los años de 1875 y 1878, momento en el cual se identifica la ruptura y emerge el proyecto político que más adelante será denominado “La Regeneración”.
Catalytic Olefin Transpositions Facilitated by Ruthenium N,N,N-Pincer Complexes
Authors: Davies Alex , Greene Kara , Allen Anthony , Stephenson Corey , Szymczak Nathaniel
Published: April 2023

Previous reports with our N,N,N-pincer Ru-hydride catalysts have shown their synthetic versatility toward various transfer hydrogenation reactions and pi-bond functionalizations. In this report, we expand the reactivity of these complexes to encompass olefin transposition/isomerizations. The protocol proceeds at room temperature for most substrates, achieving excellent yields, regioselectivity, and diastereoselectivity in short reaction times. Furthermore, we demonstrate the potential for one-pot cascade sequences of the products derived from the transposition reactions.
H2-Mediated Copper Catalyzed C–C Coupling Reactions – Selective Formation of Skipped Dienes
Authors: Brechmann Lea , Johannes Teichert
Published: April 2023

A simple copper(I)/N-heterocyclic carbene complex facilitates a H2-mediated C–C coupling reaction of internal alkynes and allylic chlorides. The catalytic protocol delivers the corresponding 1,4-dienes (skipped dienes) with high chemo-, regio- and stereoselectivity without any isomerization to the thermodynamically more stable 1,3-dienes or overreduction to the corre-sponding alkanes. The H2-mediated C–C coupling reaction allows for the exploitation “copper hydride catalysis” with H2 as terminal reducing agent and source of hydrides for forging of new C–C bonds. In this way, this approach gives rise to C–C bond forming reactions with a 3d metal without the need for a stoichiometric organometallic reducing agent.
Same Day Access to Proteins Enabled by Folding Selections
Authors: Callahan Alex J. , Rondon Aurélie , Lozano Salazar Lia , Gandhesiri Satish , Rodriguez Jacob , Loas Andrei , Pentelute Bradley
Published: April 2023

From laundry detergent to biomedicines, proteins are core components of modern technology. However, despite significant progress, modern recombinant protein expression still requires days to months to deliver pure, functional material. Chemical protein synthesis can also afford proteins for study with similar timeframes at the chemistry stage, with additional time dedicated post-synthesis for handling as separation of the numerous closely related side-products requires weeks to months. To overcome these rate-limiting barriers, we propose folding selection as a new framework to understand synthetic side products and enable rapid purification. We demonstrate that the minor chemical modifications present on synthetic side products result in substantially altered physical-chemical properties and that simple bio-purification techniques can separate them from the native protein in hours. With this strategy, we demonstrate the production of nine functional synthetic proteins in under ten hours each, including disulfide-containing enzymes and transcription factor domains with non-natural amino acids. Furthermore, only possible with this technology, we access homogeneous, post-translationally modified (e.g., by phosphorylation or acetylation) proteins in milligram amounts in hours. Understanding protein function is a cornerstone of modern biology, and the same-day protein production described here is uniquely suited to accelerate these efforts.
Computational Insights into the Inhibition Mechanism of Xanthine Oxidoreductase by Oxipurinol
Authors: Maghsoud Yazdan , Dong Chao , Cisneros G. Andrés
Published: April 2023

Xanthine oxidoreductase (XOR) is a molybdopterin-containing enzyme found in many living organisms. Its function is to convert hypoxanthine to xanthine and subsequently to urate, which are the final steps in purine elimination in humans. Elevated uric acid levels in the human body can cause gout and hyperuricemia. Therefore, drug development efforts targeting this enzyme are a primary focus not only to treat these conditions but also for other diseases. Oxipurinol, an analog of xanthine, was the drug that emerged as a “gold standard” inhibitor of XO in the late sixties. Crystallographic studies have shown direct coordination of oxipurinol to the molybdenum cofactor (MoCo). The proposed inhibition mechanism based on available crystal structures posits that the oxipurinol’s nitrogen replaces a water-exchangeable OH ligand of the Mo atom. However, the detailed steps involved in the inhibition mechanism remain undefined, which would provide important insights for designing more efficacious drugs with similar inhibition functions. In this study, the inhibition mechanism of XOR by oxipurinol is investigated via molecular dynamics (MD) and quantum mechanics/molecular mechanics (QM/MM) calculations. The structural and dynamical effects of oxipurinol on the pre-catalytic structure of the metabolite-bound system are presented, as well as the modeled reaction mechanism catalyzed by the MoCo center in the active site. The kinetics and thermodynamics of the proposed reaction mechanism as well as the non-covalent interactions with the binding cavity align with experimental findings. Our results also suggest the suitability of the inhibition reaction via another tautomer of oxipurinol other than the experimentally predominant tautomer. This might suggest possible routes for designing new analogs of oxipurinol with a similar coordination mode to the latter tautomer, which could lead to more energetically favorable inhibitors.
Design Rules for Two-Dimensional Organic Semiconductor-Incorporated Perovskites (OSiP) Gleaned from Thousands of Simulated Structures
Authors: Lin Zih-Yu , Sun Jiaonan , Shiring Stephen , Dou Letian , Savoie Brett
Published: April 2023

Organic-inorganic hybrid perovskite semiconductors are under investigation for many applications owing to their excellent optoelectronic properties and relatively simple processing. Two-dimensional (2D) halide perovskites are an attractive class of hybrid perovskites that have additional optoelectronic tunability due to their accommodation of relatively large organic ligands. Nevertheless, contemporary ligand design depends on either expensive trial-and-error testing of whether a ligand can be integrated within the lattice or conservative heuristics that unduly limit the scope of ligand chemistries. Here, the structural determinants of ligand incorporation and perovskite stability are established by molecular dynamics (MD) simulations of over ten thousand perovskites, including an algorithmically generated set of prospective ligand chemistries and all previously reported experimental primary ammonium ligands based on C, H, O, S, and N. The simulation results show near-perfect predictions of positive and negative literature examples, predict trade-offs between several ligand features and perovskite stability, and ultimately predict an inexhaustibly large 2D-compatible ligand design space. This dataset is used to train machine learning classifiers capable of predicting the geometric stability of perovskite structures based solely on generalizable ligand features, thus providing an inexpensive tool for screening putative ligands. As a demonstration, the model was used to down-select five new ligands that were successfully synthesized and incorporated into 2D perovskites. This work provides a new paradigm for future low-dimensional perovskite design.
Professionally oriented language training foreign higher education acquires
Authors: Chernovalyuk I.
Published: April 2023

The article is devoted to the solution of the linguistic didactic problem relevant for modern higher education – the definition of the scientific and methodological foundations of professionally oriented language training of foreign students. The purpose of the article is to substantiate the main methodical mechanisms for the implementation of the tasks of the professional orientation of the language training of foreign bachelors. Foreign language communicative competence is an important component of the readiness of future specialists to carry out professional activities in modern conditions. For students of higher education, a foreign language plays the role of an educational discipline, a means of learning and professional improvement.

The following methods of scientific research were used: analysis of current sources on the topic of research, study of the experience of domestic and foreign pedagogy in teaching professional speech, implementation of selected approaches and methods in practice, analysis of approbation of proposed methodological solutions. The article systematizes modern approaches to selecting the content of communication training in the professional field of communicative connection. The content of concepts has been clarified: the principle of professional orientation of language education, the professional component of communicative competence, requirements for the content of professionally oriented educational content, the characteristics of the methods of teaching foreign students of professional speech have been clarified.

It was established that the formation of the professional component of communicative competence in modern conditions requires the involvement of additional educational tools and the development of methodically appropriate techniques, the definition of language training forms, the creation of motivational pedagogical conditions that contribute to the formation of a positive attitude to the learning process. To implement the specified linguistic and didactic conditions, a program that considers modern requirements for language and speech content, the introduction of innovative technologies into the learning process has been developed.

The proposed approach to the selection of content and teaching methods ensures the formation of a professional component of foreign language competence and allows for the effective organization of the educational process in academic groups of foreign students studying in economic education programs. Prospects for further research of this problem lie in the development of innovative methodical support for the formation of the professional component of the communicative competence of foreign students, increasing the efficiency of the organization and achieving high effectiveness of the educational process.
Kabul ve Kararlılık Terapisinin Depresyonda Ele Alınması: Vaka Sunumu (Managing Depression with Acceptance and Commitment Therapy: Case Report)
Authors: Gök Bayram Ali , Karaaziz Meryem
Published: April 2023

Kabul ve Kararlılık Terapisi (KKT), farkındalık temelli üçüncü dalga davranışçı terapilerden biridir. KKT, olaylara önyargısız şekilde yaklaşan, dili yargılamadan anl aşılmak amacıyla kullanan ve şimdiki anda bulunmayı teşvik eden terapi modelidir. KKT’de amaç semptomları değiştirmek değildir. Asıl amaç, acı verici düşünce ve duyguları eski halinden zengin ve anlamlı olan normal insan deneyimlerine dönüştürmektir. Istıraplı düşünceler anlamlı hale getirilirkenpsikolojik esneklik bileşenleriyle alakalı metaforlar ve etkinliklerden yararlanılmaktadır.Depresyonda da çeşitli şekillerde esneklik kaybına uğramış ve psikolojik katılık yaşanılan yaygın patolojik bir durum bulunmaktadır. Bu araştırmanın amacı KKT’nin bireysel terapide kişisel ve kişiler arası zorluklara neden olan majör depresyon tanılı danışanda uygulanmasıdır. Danışana ön test-son test şeklinde Psikolojik Esneklik Ölçeği ve Depresyon Ölçeği uygulanarak terapi açısından etkinliği belirlenmiştir. Araştırmanın sonucunda majör depresyon tanısı konan danışanda depresyonu azaltmada ve farkındalığı artırmada KKT etkinliği için ön kanıtların sağlandığı görülmüştür. Araştırmanın vaka analizi olması nedeniyle gelecek çalışmalarda daha fazla danışan üzerinde gerçekleştirilmesi gerekmektedir.
Synthesis and Validation of Fluorescence in situ Hybridisation
Probes (FISH) for Genotyping Mouse Models of Embryonic
Lethal Aneuploidies
Authors:   , Derecourt Niamh
Published: April 2023

Approximately 50% of all embryos produced in fertility clinics have an abnormal number of chromosomes (i.e., aneuploid)(Vera-Rodriguez et al., 2015). Of these, 25% have aneuploidies that are embryonic lethal (O’Connor, 2008) and result in spontaneous abortions in the first trimester(Chen et al., 2017). My research contributes to wider research programme that aimsto develop a non-invasive method for detecting aneuploidies in preimplantation humanembryos. For the overarching research program, several models of embryonic lethal aneuploidies must be developed and validated.

One way to produce embryonic lethal aneuploidies is through mouse breeding programmes that make use of Robertsonian translocations. Robertsonian translocations (RobT) are one of the most common forms of chromosomal rearrangements in humans and can cause whole chromosome duplications/deletions(Zhuang et al., 2014). A balanced carrier of these RobT is viable but produces normal gametes, carrier gametes, as well as gametes that will result in aneuploid (trisomy or monosomy) embryos(Beyer & Willats, 2017).

As these RobT mouse models are being developed in our laboratory, an accurate method for identifying the trisomic and monosomic (i.e., aneuploid) embryos produced is critical. This project aims to synthesise and validate fluorescence in situ hybridisation (FISH) point probes for mouse chromosomes 4, 10, 11, and 15 using a cost-effective, PCR-based method (Bienko et al., 2013). Herein, I present data from experiments that were conducted to validate FISH probes for mouse chromosome 4, 10, 11, and 15. I also describe a series of experiments to optimise metaphase spread preparation from two different sample types, mouse lymphocytes and cleavage stage embryos.

From this study, four FISH probes (specific for chromosome 4, 10, 11, & 15) were synthesised. Based on existing metrics, these were determined to be sufficiently labelled and at a high enough concentration to be evaluated as FISH probes. However, when FISH was performed using each of these probes, no specific signal due to hybridisation was observed.

This is despite attempts to identify and address the cause of this lack of binding. Despite this, a positive, pan-centromeric control was successfully validated using the optimised FISH protocol. Also, metaphase spread protocols for two different tissue types were also devised to produce a reliable sample source for FISH validation. Overall, this project has shown that these PCR based point probes are not appropriate for the genotyping of RobT induced aneuploidies and other forms of genotyping should be considered.
ÖĞRETMEN ADAYLARININ KOPYA ÇEKME DAVRANIŞINA İLİŞKİN GÖRÜŞLERİNİN İNCELENMESİ
Authors: TURKAN Azmi , TÜRK Nuri , ÖZDEMİR Muhittin
Published: April 2023

Eğitim öğretim faaliyetlerinde ahlaki ve etik değerlerin kimi zaman göz ardı edildiği durumlar ile karşılaşıla bilinmektedir. Bu davranışlardan biri olan kopya çekme, eğitsel süreçler içinde öğrencilerin gerçekleştirdiği etik ve ahlaki olmayan davranışlar içerisinde ele alınabilir. Bu araştırmanın amacı, öğretmen adaylarının kopya çekme davranışına yönelik görüşlerinin öğrenci, öğretmen ve gözetmenin görevini icra etmesi açısından incelenmesi ve kopya çekme nedenlerinin belirlenmesidir. Ayrıca öğretmen adaylarının, kopya çekme davranışını etik ve ahlaki değerler bağlamında nasıl değerlendirdikleri belirlenmeye çalışılmıştır. Araştırmada nitel araştırma yöntemlerinden fenomenolojik desen kullanılmıştır. Araştırmanın örneklemini amaçlı örnekleme yöntemlerinden ölçüt örnekleme ile belirlenmiş 28 öğretmen adayı oluşturmaktadır. Bu araştırmanın ölçütü, öğretmen eğitiminde lisans eğitim seviyesinde Eğitimde Ahlak ve Etik dersini almak olarak belirlenmiştir. Verilerin toplanması için yarı yapılandırılmış görüşme formu kullanılmıştır. Nvivo nitel analiz programında veriler içerik analizi tekniği kullanılarak analiz edilmiştir. Araştırma bulguları, öğrencilerinin akademik, duygusal ve sistemsel nedenlerden ötürü kopya çektiklerini göstermektedir. Katılımcılar kopya çekme davranışını değerler açısından değerlendirirken danışman, öğrenci ve öğretmen bağlamında ele almışlardır.
LEİPZİG KÜTÜPHANESİNDE KAYITLI MÜELLİFİ BİLİNMEYEN BİR SAATNAME ÖRNEĞİ
Authors: BARS Mehmet Emin
Published: April 2023

Türk-İslam kültüründe bilinmeyeni ve geleceği öğrenmeye yönelik çeşitli uygulamaları konu edinen ilimler vardır. Bu ilimlerden biri de ilm-i nücumdur. İlm-i nücum zaman zaman falcılıkla ilişkilendirilip gerçek dışı ilim olarak görülmesine rağmen toplumu derinden etkilemiştir. Yıldızların insanların yaptıkları işler üzerinde etkili olduğuna dair inançlar bu ilme bağlı “saatname” adı verilen türün meydana gelmesini sağlamıştır. Bu tür eserlere hem halk hem de yöneticiler tarafından itibar edilmiştir. Saatnamelerde yedi yıldızın günlerin yedi vaktindeki işler üzerindeki etkisi konu edinmiştir. Saatname türü ile ilgili farklı kütüphanelerde çok sayıda yazma nüsha bulunmaktadır. Ancak bu tür eserlerin çoğu henüz incelenmemiştir. Saatname türü ile ilgili bilimsel alanda az sayıda çalışma bulunmaktadır. Bu çalışmada Almanya Leipzig Kütüphanesi Fleischer Kataloğu’nda yer alan müellifi bilinmeyen el yazması mensur bir saatname örneği incelenmiştir. Küçük bir risale şeklinde düzenlenen metin, saatlerin hükümlerini bildirmek, hangi saatte hangi işlerin yapılmasının iyi hangilerinin kötü olduğunu belirtmek için yazılmıştır. Metinde yedi yıldızın yedi günün yedi vaktindeki olumlu ve olumsuz tesirleri anlatılmıştır. Yıldızların gün ve vakitler üzerindeki tesirleri düzenli belli bir dairesel döngü halinde devam etmektedir. Yıldızların uğurlu işler üzerindeki etkisinin daha fazla olduğu görülmüştür. Dikkat çekici başka bir özellik de bazı yıldızların hüküm sürdüğü zamanlarda uğursuz herhangi bir işten söz edilmemesidir. Genel olarak kısa bir tür olan saatnamelerin çok sayıda örneğinin toplu biçimde değerlendirilmesi Türk kültür tarihi açısından önemlidir.
The Social Future of Academic Libraries
Authors: Schlak Tim , Corrall Sheila , Bracke Paul
Published: April 2023

The Social Future of Academic Libraries starts with the developments in thinking and practice that constitute the ‘social turn’ in communities, professions, the economy, the academy and libraries, while also introducing the core concepts of intellectual and social capital and networks. Part II presents nine case studies illustrating how social capital perspectives and social network theory can facilitate organisational learning, service development and collaborative relationships across different areas of library practice. Examples cover collection development, data services, information literacy, liaison librarians, library fundraising, service design, space utilisation, subject specialists and student success. The volume is accompanied by a keyword guide to the concepts, theories and models referenced in the text via two downloadable glossaries with related bibliographies to inform current reading and future work.