bluuebunny/crossref_metadata_2025 huggingface dataset:
Health Maintenance Consensus for Adults With Inflammatory Bowel Disease
Authors: Syal Gaurav , Serrano Mariastella , Jain Animesh , Cohen Benjamin L , Rieder Florian , Stone Christian , Abraham Bincy , Hudesman David , Malter Lisa , McCabe Robert , Holubar Stefan , Afzali Anita , Cheifetz Adam S , Gaidos Jill K J , Moss Alan C
Published: July 2021

Background

With the management of inflammatory bowel disease (IBD) becoming increasingly complex, incorporating preventive care health maintenance measures can be challenging. The aim of developing these updated recommendations is to provide more specific details to facilitate their use into a busy clinical practice setting.

Method

Fifteen statements were formulated with recommendations regarding the target, timing, and frequency of the health maintenance interventions in patients with IBD. We used a modified Delphi method and a literature review to establish a consensus among the panel of experts. The appropriateness of each health maintenance statement was rated on a scale of 1 to 5 (1–2 as inappropriate, and 4–5 as appropriate) by each panelist. Interventions were considered appropriate, and statements were accepted if ≥80% of the panelists agreed with a score ≥4.

Results

The panel approved 15 health maintenance recommendations for adults with IBD based on the current literature and expert opinion. These recommendations include explicit details regarding specific screening tools, timing of screening, and vaccinations for adults with IBD.

Conclusions

Patients with IBD are at an increased risk for infections, malignancies, and other comorbidities. Given the complexity of caring for patients with IBD, this focused list of recommendations can be easily incorporated in to clinical care to help eliminate the gap in preventative care for patients with IBD.
Prognostic factors for survival in patients with lung metastases from gynaecological tract cancers
Authors: Chiappetta Marco , Gallotta Valerio , Pogliani Luca , Zanfrini Edoardo , Fagotti Anna , Ferrandina Gabriella , Fanfani Francesco , Nachira Dania , Meacci Elisa , Congedo Maria Teresa , Lococo Filippo , Giudice Maria Teresa , Scambia Giovanni , Margaritora Stefano
Published: July 2021

OBJECTIVES

Lung metastases from gynaecological tract cancers are rare, and prognostic factors are still undefined. The goal of this study was to analyse prognostic factors for survival in this group of patients.

METHODS

Data of patients with lung metastases from gynaecological tract cancers who underwent surgical resections from 1 January 2005 to 31 May 2019 were reviewed retrospectively. All patients were treated surgically if the primitive tumour was under control and the lung was the only organ involved. Clinical and pathological data associated with metastatic patterns and previous treatment types were correlated with overall survival (OS) and disease-free survival using Kaplan–Meier curves, whereas the log-rank test was used to assess differences between subgroups.

RESULTS

The analysis was conducted on 55 patients. OS was 65% at 5 years. With univariable analysis, age >45 years (P = 0.022) and the absence of pleural infiltration (P = 0.001) were determined to be favourable prognostic factors. The 5-year OS was 69.9% versus 53.3% in patients with pleural involvement. Multivariable analysis confirmed the absence of pleural infiltration as a favourable independent prognostic factor; the hazard ratio was 0.06; the 95% confidence interval was 0.00–0.23 (P = 0.011).

At univariable analysis, the absence of pleural infiltration was determined to be a favourable prognostic factor (P = 0.034) for disease-free survival. The numbers and dimensions of the metastases did not influence survival in these patients.

In uterine cancers of endometrial or cervical origin, the presence of pleural infiltration (P = 0.001), lymph node involvement (P = 0.001) and young age (P = 0.044) were considered unfavourable prognostic factors for OS.

CONCLUSIONS

Surgical treatment in technically resectable gynaecological tract metastases may represent an important option. Pleural infiltration and lymph node metastases seem to be adverse prognostic factors.
How is the Theoretical Domains Framework applied in designing interventions to support healthcare practitioner behaviour change? A systematic review
Authors: Dyson Judith , Cowdell Fiona
Published: July 2021

Background

The use of theory is recommended to support interventions to promote implementation of evidence-based practices. However, there are multiple models of behaviour change which can be complex and lack comprehensiveness and are therefore difficult to understand and operationalize. The Theoretical Domains Framework sought to address these problems by synthesizing 33 models of behaviour or behaviour change. Given that it is 15 years since the first publication of the Theoretical Domains Framework (TDF), it is timely to reflect on how the framework has been applied in practice.

Objective

The objective of this review is to identify and narratively synthesize papers in which the TDF, (including frameworks that incorporate the TDF) have been used have been used to develop implementation interventions.

Methods

We searched MEDLINE, PsychINFO, CINAHL and the Cochrane databases using the terms: ‘theoretical domains framework*’ or TDF or Capability, Opportunity, Motivation to Behaviour (COM-B) or ‘behav* change wheel’ or ‘BCW’ AND implement* or improv* or quality or guideline* or intervention* or practice* or EBP or ‘evidence based practice’ and conducted citation and key author searches. The included papers were those that used any version of the TDF published from 2005 onwards. The included papers were subject to narrative synthesis.

Results

A total of 3540 papers were identified and 60 were included. Thirty-two papers reported intervention design only and 28 reported intervention design and testing. Despite over 3000 citations there has been limited application to the point of designing interventions to support the best practice. In particular use of the framework has not been tried or tested in non-western countries and barely used in non-primary or acute care settings. Authors have applied the framework to assess barriers and facilitators successfully but reporting of the process of selection of behaviour change techniques and intervention design thereafter was variable.

Conclusion

Despite over three thousand citations of the framework there has been limited application to the point of designing interventions to support best practice. The framework is barely used in non-western countries or beyond primary or acute care settings. A stated purpose of the framework was to make psychological theory accessible to researchers and practitioners alike; if this is to be fully achieved, further guidance is needed on the application of the framework beyond the point of assessment of barriers and facilitators.
Development and Validation of a Stability-Indicating Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC) Method for Identification, Assay, and Estimation of Related Substances of Ivermectin Drug Substance
Authors: Wimalasinghe Rasangi M , Zhao Daoli , Wang Lin , Rustum Abu
Published: July 2021

Background

Ivermectin is a potent semi-synthetic antiparasitic drug used in veterinary medicine. It is widely used for the treatment of parasites.

Objective

This study aimed to develop a stability-indicating reversed-phase HPLC (RP-HPLC) method for assay and identification of ivermectin including identification and estimation of its related substances in bulk drug substance batches of ivermectin.

Method

Ivermectin and its related substances were separated on an Ascentis Express C18 column (100 mm × 4.6 mm id, 2.7 µm particle size) maintained at 45°C (column temperature) on an HPLC system with gradient elution. The mobile phase was composed of water − acetonitrile (ACN; 50 + 50, v/v) as mobile phase A, and isopropanol − ACN (15 + 85, v/v) as mobile phase B. Analytes were detected with a detection wavelength of 252 nm and quantitated against an external reference standard of ivermectin with a quantitation limit of 0.1% of the target (analytical) concentration.

Results

The HPLC method was able to separate all analytes of interest by gradient elution within 25 min. The method was validated according to the guidelines described in the International Conference on Harmonization guideline Q2(R1).

Conclusions

The HPLC method for assay of ivermectin and estimation of its related substances was successfully developed, validated, and demonstrated to be accurate, robust, specific, and stability indicating.

Highlights

The performance of the HPLC method is significantly faster and possesses a higher degree of selectivity. Implementation of this method for routine analysis in QC laboratories would save significant time, resources and solvents.
Effects of roughage type on particle separation, rumination, fiber mat characteristics, in situ degradation, and ruminal fermentation parameters in beef steers
Authors: Lockard Catherine L , Lockard Caleb G , Smith Wyatt N , Karr Kendall J , Holland Ben P , Word Alyssa B , Foster Jamie L , Jennings Jenny S
Published: July 2021

Six ruminally cannulated steers (average BW = 791 + 71 kg) were used in a replicated 3 × 3 Latin square experiment to determine the effects of roughage type on rumination, fiber mat characteristics, and rumen fermentation variables. Three roughages were included at 7% (DM basis) in a steam flaked corn-based diet; cotton burrs (CB), wheat silage (WS), or corn stalks (CS). Steers were fitted with a sensory collar to record rumination behaviors in 2-h intervals at the beginning of the experiment. Each 30-d period consisted of a 7-d of recovery, 14-d of diet adaptation, 7-d of rumination data collection (daily and bi-hourly average rumination), 1-d of rumen fluid collection, and 1-d of rumen evacuations. In situ degradation of individual roughages was determined for 4-d after period 3 evacuations. During rumen evacuations, ruminal contents were removed; the rumen fiber mat (RF) was separated from the liquid portion with a 2 mm sieve, weighed, and a subsample was dried. Data were analyzed using the MIXED procedure of SAS with steer as the experimental unit and roughage (CB, WS, and CS) as the main effect. Dry matter intake (DMI) was not different for CB and WS (P = 0.25) and greatest for steers consuming CS diet (P  < 0.01). Roughage type did not influence the weight of the RF dry matter (%; DM; P = 0.92), RF weight (P = 0.69), or RF:DMI ratio (P = 0.29). Daily rumination (min/d) did not differ among roughages (P = 0.40), but min of rumination/kg of DMI was greatest for CS (18.0 min), min/kg of NDF was greatest for WS (89.8 min; P = 0.02), and min/kg of peNDF was greatest for CS (132.4 min; P  < 0.01). Wheat silage had the greatest percentage of soluble DM and CB-R and CS-R (P  < 0.01) had the greatest ruminal degraded DM fraction. Rumen fiber mat did not differ for roughages, although rumination min/kg of DMI and peNDF was greatest for steers consuming CS and WS. In situ degradation determined that CB-R and CS-R had the greatest percentage of ruminal degraded DM. Based on the objective of the experiment, roughage type did not influence daily rumination or fiber mat characteristics.
Interplay Between Oxytetracycline and the Homozygotekdr(L1014F) Resistance Genotype on Fecundity inAnopheles gambiae(Diptera: Culicidae) Mosquitoes
Authors: Medjigbodo Adandé A , Sonounameto Eric G , Djihinto Oswald Y , Abbey Emmanuella , Salavi Esther B , Djossou Laurette , Badolo Athanase , Djogbénou Luc S
Published: July 2021

The insecticide resistance in Anopheles gambiae mosquitoes has remained the major threat for vector control programs but the fitness effects conferred by these mechanisms are poorly understood. To fill this knowledge gap, the present study aimed at testing the hypothesis that antibiotic oxytetracycline could have an interaction with insecticide resistance genotypes and consequently inhibit the fecundity in An. gambiae. Four strains of An. gambiae: Kisumu (susceptible), KisKdr (kdr (L1014F) resistant), AcerKis (ace-1 (G119S) resistant) and AcerKdrKis (both kdr (L1014F) and ace-1 (G119S) resistant) were used in this study. The different strains were allowed to bloodfeed on a rabbit previously treated with antibiotic oxytetracycline at a concentration of 39·10–5 M. Three days later, ovarian follicles were dissected from individual mosquito ovaries into physiological saline solution (0.9% NaCl) under a stereomicroscope and the eggs were counted. Fecundity was substantially lower in oxytetracycline-exposed KisKdr females when compared to that of the untreated individuals and oxytetracycline-exposed Kisumu females. The exposed AcerKis females displayed an increased fecundity compared to their nontreated counterparts whereas they had reduced fecundity compared to that of oxytetracycline-exposed Kisumu females. There was no substantial difference between the fecundity in the treated and untreated AcerKdrKis females. The oxytetracycline-exposed AcerKdrKis mosquitoes had an increased fecundity compared to that of the exposed Kisumu females. Our data indicate an indirect effect of oxytetracycline in reducing fecundity of An. gambiae mosquitoes carrying kdrR (L1014F) genotype. These findings could be useful for designing new integrated approaches for malaria vector control in endemic countries.
Evaluating the importance of wolverine habitat predictors using a machine learning method
Authors: Carroll Kathleen A , Hansen Andrew J , Inman Robert M , Lawrence Rick L
Published: July 2021

In the conterminous United States, wolverines (Gulo gulo) occupy semi-isolated patches of subalpine habitats at naturally low densities. Determining how to model wolverine habitat, particularly across multiple scales, can contribute greatly to wolverine conservation efforts. We used the machine-learning algorithm random forest to determine how a novel analysis approach compared to the existing literature for future wolverine conservation efforts. We also determined how well a small suite of variables explained wolverine habitat use patterns at the second- and third-order selection scale by sex. We found that the importance of habitat covariates differed slightly by sex and selection scales. Snow water equivalent, distance to high-elevation talus, and latitude-adjusted elevation were the driving selective forces for wolverines across the Greater Yellowstone Ecosystem at both selection orders but performed better at the second order. Overall, our results indicate that wolverine habitat selection is, in large part, broadly explained by high-elevation structural features, and this confirms existing data. Our results suggest that for third-order analyses, additional fine-scale habitat data are necessary.
Disentangling the complex alpha taxonomy of Andean populations of Ctenomys (Rodentia: Ctenomyidae) from northern Patagonia: the need for extensive sampling in heterogeneous landscapes
Authors: Tammone Mauro N , Lacey Eileen A , Voglino Damián , Cuéllar Soto Erika , Pardiñas Ulyses F J
Published: July 2021

In the Andean portion of northern Patagonia, populations of Ctenomys are found from low-elevation plains to high-elevation meadows and valleys. Despite their prevalence, the taxonomy of these subterranean rodents remains poorly resolved. Using genetic and morphological data obtained from museum specimens and animals collected in the field, we examined the taxonomy of Ctenomys from southwestern Mendoza Province, Argentina. Our analyses suggest the presence of at least five species of Ctenomys within the study area. The highest, innermost portion of the Andes is occupied by C. maulinus. To the east, the mountains and foothills are inhabited by two forms associated with the “mendocinus” and the “magellanicus” lineages, respectively. The former appears to be a local variant of C. emilianus, while the latter is sister to C. pontifex. Although C. pontifex was not encountered during our field sampling, it remains a valid species that likely is restricted to the isolated Valle Hermoso in westernmost Mendoza Province. In addition, we report an undescribed form from Las Leñas Valley that is associated with the “mendocinus” lineage. This complex alpha taxonomic scenario occurs within less than one degree of latitude, thereby highlighting the need to conduct detailed field collections to improve our knowledge of the systematics of Ctenomys.
Transcription factor MaMADS36 plays a central role in regulating banana fruit ripening
Authors: Liu Juhua , Liu Mengting , Wang Jingyi , Zhang Jing , Miao Hongxia , Wang Zhuo , Jia Caihong , Zhang Jianbin , Xu Biyu , Jin Zhiqiang
Published: July 2021

Bananas are model fruits for studying starch conversion and climactericity. Starch degradation and ripening are two important biological processes that occur concomitantly in banana fruit. Ethylene biosynthesis and postharvest fruit ripening processes, i.e. starch degradation, fruit softening, and sugar accumulation, are highly correlated and thus could be controlled by a common regulatory switch. However, this switch has not been identified. In this study, we transformed red banana (Musa acuminata L.) with sense and anti-sense constructs of the MaMADS36 transcription factor gene (also MuMADS1, Ma05_g18560.1). Analysis of these lines showed that MaMADS36 interacts with 74 other proteins to form a co-expression network and could act as an important switch to regulate ethylene biosynthesis, starch degradation, softening, and sugar accumulation. Among these target genes, musa acuminata beta-amylase 9b (MaBAM9b, Ma05_t07800.1), which encodes a starch degradation enzyme, was selected to further investigate the regulatory mechanism of MaMADS36. Our findings revealed that MaMADS36 directly binds to the CA/T(r)G box of the MaBAM9b promoter to increase MaBAM9b transcription and, in turn, enzyme activity and starch degradation during ripening. These results will further our understanding of the fine regulatory mechanisms of MADS-box transcription factors in regulating fruit ripening, which can be applied to breeding programs to improve fruit shelf-life.
Chemical enrichment and radial migration in the Galactic disc – the origin of the [αFe] double sequence
Authors: Sharma Sanjib , Hayden Michael R , Bland-Hawthorn Joss
Published: July 2021

The ([α/Fe], [Fe/H]) distribution of Milky Way stars shows at least two distinct sequences, which have traditionally been associated with the thin and thick disc components. The abundance distribution varies systematically with location R and |z| across the Galaxy. We reproduce this using an analytical chemodynamical model that includes the effects of radial migration and kinematic heating. Unlike some earlier models, our scheme does not require a distinct thick disc component emerging from a separate evolutionary path. The proposed model has a continuous star formation history and a continuous age velocity dispersion relation. Moreover, [α/Fe] is constant for stellar ages less than 8 Gyr, but increases sharply for older stars over a time-scale of 1.5 Gyr. The gap between the two sequences is due to this sharp transition. We show that the high-[α/Fe] sequence at the low-metallicity end is simply a pile-up of old stars, but towards the high-metallicity end, the age progressively decreases and stars have small birth radii. Our model successfully explains the uniformity of the locus of the high-[α/Fe] sequence across different locations. The low-[α/Fe] sequence contains stars with different birth radii that owes its existence to radial migration. For the low-[α/Fe] stars, angular momentum is anticorrelated with [Fe/H], while the opposite is true for high-[α/Fe] stars. We show that the later trend can be explained by the increase of circular velocity with time. If radial migration is not included, the model fails to generate the double sequence and instead shows only a single sequence. Our simple scheme has major advantages over earlier chemodynamical models, as we show.
3D MHD astrospheres: applications to IRC-10414 and Betelgeuse
Authors: Meyer D M-A , Mignone A , Petrov M , Scherer K , Velázquez P F , Boumis P
Published: July 2021

A significative fraction of all massive stars in the Milky Way move supersonically through their local interstellar medium (ISM), producing bow shock nebulae by wind-ISM interaction. The stability of these observed astrospheres around cool massive stars challenges precedent 2D (magneto-)hydrodynamical (MHD) simulations of their surroundings. We present 3D MHD simulations of the circumstellar medium of runaway M-type red supergiant stars moving with velocity $v_{\star }=50\, \rm km\, \rm s^{-1}$. We treat the stellar wind with a Parker spiral and assume a $7\, \rm \mu G$ magnetization of the ISM. Our free parameter is the angle θmag between ISM flow and magnetization, taken to 0°, 45°, and 90°. It is found that simulation dimension, coordinate systems, and grid effects can greatly affect the development of the modelled astrospheres. Nevertheless, as soon as the ISM flow and magnetization directions differs by more than a few degrees (θmag ≥ 5°), the bow shock is stabilized, most clumpiness and ragged structures vanishing. The complex shape of the bow shocks induce important projection effects, e.g. at optical H α line, producing complex of astrospheric morphologies. We speculate that those effects are also at work around earlier-type massive stars, which would explain their diversity of their observed arc-like nebula around runaway OB stars. Our 3D MHD models are fitting well observations of the astrospheres of several runaway red supergiant stars. The results interpret the smoothed astrosphere of IRC-10414 and Betelgeuse (αOri) are stabilized by an organized non-parallel ambient magnetic field. Our findings suggest that IRC-10414 is currently in a steady state of its evolution, and that Betelgeuse’s bar is of interstellar origin.
Rise and fall of post-starburst galaxies in Magneticum Pathfinder
Authors: Lotz Marcel , Dolag Klaus , Remus Rhea-Silvia , Burkert Andreas
Published: July 2021

Post-starburst (PSB) galaxies belong to a short-lived transition population between star-forming (SF) and quiescent galaxies. Deciphering their heavily discussed evolutionary pathways is paramount to understanding galaxy evolution. We aim to determine the dominant mechanisms governing PSB evolution in both the field and in galaxy clusters. Using the cosmological hydrodynamical simulation suite Magneticum Pathfinder, we identify 647 PSBs with z ∼ 0 stellar mass $M_* \ge 5 \times 10^{10} \, \mathrm{M_{\odot }}$ . We track their galactic evolution, merger history, and black hole activity over a time-span of $3.6\,$ Gyr. Additionally, we study cluster PSBs identified at different redshifts and cluster masses. Independent of environment and redshift, we find that PSBs, like SF galaxies, have frequent mergers. At z = 0, $89{{\ \rm per\ cent}}$ of PSBs have experienced mergers and $65{{\ \rm per\ cent}}$ had at least one major merger within the last $2.5\,$ Gyr, leading to strong star formation episodes. In fact, $23{{\ \rm per\ cent}}$ of z = 0 PSBs were rejuvenated during their starburst. Following the mergers, field PSBs are generally shutdown via a strong increase in active galactic nucleus (AGN) feedback (power output $P_{\rm AGN,PSB} \ge 10^{56}\,$ erg Myr−1). We find agreement with observations for both stellar mass functions and z = 0.9 line-of-sight phase space distributions of PSBs in galaxy clusters. Finally, we find that z ≲ 0.5 cluster PSBs are predominantly infalling, especially in high-mass clusters and show no signs of enhanced AGN activity. Thus, we conclude that the majority of cluster PSBs are shutdown via an environmental quenching mechanism such as ram-pressure stripping, while field PSBs are mainly quenched by AGN feedback.
Ionizing photon production of Population III stars: effects of rotation, convection, and initial mass function
Authors: Murphy Laura J , Groh Jose H , Farrell Eoin , Meynet Georges , Ekström Sylvia , Tsiatsiou Sophie , Hackett Alexander , Martinet Söbastien
Published: July 2021

The first stars are thought to be one of the dominant sources of hydrogen reionization in the early Universe, with their high luminosities and surface temperatures expected to drive high ionizing photon production rates. In this work, we take our Geneva stellar evolution models of zero-metallicity stars and predict their production rates of photons capable to ionize H, He i, and He ii, based on a blackbody approximation. We present analytical fits in the range 1.7–500 $\, \mathrm{M}_{\odot }$. We then explore the impact of stellar initial mass, rotation, and convective overshooting for individual stars. We have found that ionizing photon production rates increase with increasing initial mass. For the rotational velocities considered we see changes of up to 25 per cent to ionizing photons produced. This varies with initial mass and ionizing photon species and reflects changes to surface properties due to rotation. We have also found that higher convective overshooting increases ionizing photon production by approximately 20 per cent for the change in overshooting considered here. For stellar populations, we explore how the production of ionizing photons varies as a function of the initial mass function (IMF) slope, and minimum and maximum initial masses. For a fixed population mass we have found changes of the order of 20–30 per cent through varying the nature of the IMF. This work presents ionizing photon production predictions for the most up to date Geneva stellar evolution models of Population III stars, and provides insight into how key evolutionary parameters impact the contribution of the first stars to reionization.
Searching for the shadows of giants – II. The effect of local ionization on the Ly α absorption signatures of protoclusters at redshift z ∼ 2.4
Authors: Miller Joel S A , Bolton James S , Hatch Nina A
Published: July 2021

Local variations in the intergalactic medium (IGM) neutral hydrogen fraction will affect the Ly α absorption signature of protoclusters identified in tomographic surveys. Using the IllustrisTNG simulations, we investigate how the AGN proximity effect and hot, collisionally ionized gas arising from gravitational infall and black hole feedback changes the Ly α absorption associated with $M_{z=0}\simeq 10^{14}\, {\rm M}_\odot$ protoclusters at z ≃ 2.4. We find that protocluster galaxy overdensities exhibit a weak anticorrelation with Ly α transmission in IGM transmission maps, but local H$\, \rm \scriptstyle I$ ionization enhancements due to hot $T\gt 10^{6}\rm \, K$ gas or nearby AGN can disrupt this relationship within individual protoclusters. On average, however, we find that strong reductions in the IGM neutral fraction are limited to within $\lesssim 5h^{-1}\, \textrm {cMpc}$ of the dark matter haloes. Local ionization enhancements will therefore have a minimal impact on the completeness of protocluster identification in tomographic surveys if smoothing Ly α transmission maps over scales of $\sim 4 h^{-1}\, \textrm {cMpc}$, as is typically done in observations. However, if calibrating the relationship between the matter density and Ly α transmission in tomographic maps using simple analytical models for the Ly α forest opacity, the presence of hot gas around haloes can still result in systematically lower estimates of Mz = 0 for the most massive protoclusters.
DDOTI observations of gravitational-wave sources discovered in O3
Authors: Becerra R L , Dichiara S , Watson A M , Troja E , Butler N R , Pereyra M , Moreno Méndez E , De Colle F , Lee W H , Kutyrev A S , López K O C
Published: July 2021

We present optical follow-up observations with the Deca-Degree Optical Transient Imager (DDOTI) telescope of gravitational-wave (GW) events detected during the Advanced LIGO and Advanced Virgo O3 observing run. DDOTI is capable of responding to an alert in a few minutes, has an instantaneous field of about 69 deg2, and obtains 10σ upper limits of wlim = 18.5–20.5 AB mag in 1000 s of exposure, depending on the conditions. We observed 54 per cent (26 out of 48) of the unretracted GW alerts and did not find any electromagnetic counterparts. We compare our upper limits to various possible counterparts: the kilonova AT 2017gfo, models of radioactive- and magnetar-powered kilonovae, short gamma-ray burst afterglows, and active galactic nucleus (AGN) flares. Although the large positional uncertainties of GW sources do not allow us to place strong constraints during O3, DDOTI observations of well-localized GW events in O4 and beyond could meaningfully constrain models of compact binary mergers. We show that DDOTI is able to detect kilonovae similar to AT 2017gfo up to about 200 Mpc and magnetar-powered kilonovae up to 1 Gpc. We calculate that nearby (≲200 Mpc) afterglows have a high chance (≈70 per cent) to be detected by rapid (≲3 h) DDOTI observations if observed on-axis, whereas off-axis afterglows are unlikely to be seen. Finally, we suggest that long-term monitoring of massive BBH events with DDOTI could confirm or rule out late AGN flares associated with these events.
On the accuracy and precision of correlation functions and field-level inference in cosmology
Authors: Leclercq Florent , Heavens Alan
Published: July 2021

We present a comparative study of the accuracy and precision of correlation function methods and full-field inference in cosmological data analysis. To do so, we examine a Bayesian hierarchical model that predicts lognormal (LN) fields and their two-point correlation function. Although a simplified analytic model, the LN model produces fields that share many of the essential characteristics of the present-day non-Gaussian cosmological density fields. We use three different statistical techniques: (i) a standard likelihood-based analysis of the two-point correlation function; (ii) a likelihood-free (simulation-based) analysis of the two-point correlation function; (iii) a field-level analysis, made possible by the more sophisticated data assimilation technique. We find that (a) standard assumptions made to write down a likelihood for correlation functions can cause significant biases, a problem that is alleviated with simulation-based inference; and (b) analysing the entire field offers considerable advantages over correlation functions, through higher accuracy, higher precision, or both. The gains depend on the degree of non-Gaussianity, but in all cases, including for weak non-Gaussianity, the advantage of analysing the full field is substantial.
Nemertean, Brachiopod, and Phoronid Neuropeptidomics Reveals Ancestral Spiralian Signaling Systems
Authors: Thiel Daniel , Yañez-Guerra Luis A , Franz-Wachtel Mirita , Hejnol Andreas , Jékely Gáspár
Published: July 2021

Neuropeptides are diverse signaling molecules in animals commonly acting through G-protein coupled receptors (GPCRs). Neuropeptides and their receptors underwent extensive diversification in bilaterians and the relationships of many peptide–receptor systems have been clarified. However, we lack a detailed picture of neuropeptide evolution in lophotrochozoans as in-depth studies only exist for mollusks and annelids. Here, we analyze peptidergic systems in Nemertea, Brachiopoda, and Phoronida. We screened transcriptomes from 13 nemertean, 6 brachiopod, and 4 phoronid species for proneuropeptides and neuropeptide GPCRs. With mass spectrometry from the nemertean Lineus longissimus, we validated several predicted peptides and identified novel ones. Molecular phylogeny combined with peptide-sequence and gene-structure comparisons allowed us to comprehensively map spiralian neuropeptide evolution. We found most mollusk and annelid peptidergic systems also in nemerteans, brachiopods, and phoronids. We uncovered previously hidden relationships including the orthologies of spiralian CCWamides to arthropod agatoxin-like peptides and of mollusk APGWamides to RGWamides from annelids, with ortholog systems in nemerteans, brachiopods, and phoronids. We found that pleurin neuropeptides previously only found in mollusks are also present in nemerteans and brachiopods. We also identified cases of gene family duplications and losses. These include a protostome-specific expansion of RFamide/Wamide signaling, a spiralian expansion of GnRH-related peptides, and duplications of vasopressin/oxytocin before the divergence of brachiopods, phoronids, and nemerteans. This analysis expands our knowledge of peptidergic signaling in spiralians and other protostomes. Our annotated data set of nearly 1,300 proneuropeptide sequences and 600 GPCRs presents a useful resource for further studies of neuropeptide signaling.
CellCall: integrating paired ligand–receptor and transcription factor activities for cell–cell communication
Authors: Zhang Yang , Liu Tianyuan , Hu Xuesong , Wang Mei , Wang Jing , Zou Bohao , Tan Puwen , Cui Tianyu , Dou Yiying , Ning Lin , huang Yan , Rao Shuan , Wang Dong , Zhao Xiaoyang
Published: July 2021

With the dramatic development of single-cell RNA sequencing (scRNA-seq) technologies, the systematic decoding of cell-cell communication has received great research interest. To date, several in-silico methods have been developed, but most of them lack the ability to predict the communication pathways connecting the insides and outsides of cells. Here, we developed CellCall, a toolkit to infer inter- and intracellular communication pathways by integrating paired ligand-receptor and transcription factor (TF) activity. Moreover, CellCall uses an embedded pathway activity analysis method to identify the significantly activated pathways involved in intercellular crosstalk between certain cell types. Additionally, CellCall offers a rich suite of visualization options (Circos plot, Sankey plot, bubble plot, ridge plot, etc.) to present the analysis results. Case studies on scRNA-seq datasets of human testicular cells and the tumor immune microenvironment demonstrated the reliable and unique functionality of CellCall in intercellular communication analysis and internal TF activity exploration, which were further validated experimentally. Comparative analysis of CellCall and other tools indicated that CellCall was more accurate and offered more functions. In summary, CellCall provides a sophisticated and practical tool allowing researchers to decipher intercellular communication and related internal regulatory signals based on scRNA-seq data. CellCall is freely available at https://github.com/ShellyCoder/cellcall.
Risk factors for complex posttraumatic stress disorder in UK police
Authors: Steel C , Tehrani N , Lewis G , Billings J
Published: July 2021

Background

Police officers are frequently exposed to distressing and dangerous situations, increasing their risk of posttraumatic stress disorder (PTSD) and complex PTSD (C-PTSD). Research examining C-PTSD in police officers is sparse, particularly examination of the occupational risk factors for trauma symptoms.

Aims

This study aimed to examine the prevalence and risk factors for PTSD and C-PTSD in UK police officers.

Methods

A cross-sectional study was conducted using psychological health surveillance data from the UK National Police Wellbeing Service. Police officers were either from high-risk areas of work or had been referred for screening by occupational health practitioners regarding psychological distress. The primary outcome for this study was a positive screening of either PTSD or C-PTSD, measured using the International Trauma Questionnaire. A range of occupational, clinical and lifestyle factors was examined to establish their role as potential risk factors for PTSD and C-PTSD.

Results

In total, 2444 UK police officers were included, with 89% from high-risk areas of work. A prevalence of 3% for PTSD and 2% for C-PTSD was found in police officers from high-risk areas of work. Higher work stress and lower manager support were found to increase the odds of C-PTSD but not PTSD. Higher personal trauma history increased the risk for PTSD and C-PTSD equally.

Conclusions

Work-related occupational factors increased the odds of PTSD and C-PTSD in police officers, which could be important risk factors for trauma symptoms within police officers. Efforts should be made to improve the working environment of police officers to help improve their psychological well-being.
Phylogeny based on ultra-conserved elements clarifies the evolution of rails and allies (Ralloidea) and is the basis for a revised classification
Authors: Kirchman Jeremy J , Rotzel McInerney Nancy , Giarla Thomas C , Olson Storrs L , Slikas Elizabeth , Fleischer Robert C
Published: July 2021

The rails (Family Rallidae) are the most diverse and widespread group in the Gruiformes. Their extensive fossil history, global geographic distribution, and tendency to rapidly evolve flightless species on islands make them an attractive subject of evolutionary studies, but the rarity of modern museum specimens of so many rail species has, until recently, limited the scope of molecular phylogenetics studies. As a result, the classification of rails remains one of the most unsettled among major bird radiations. We extracted DNA from museum specimens of 82 species, including 27 from study skins collected as long ago as 1875, and generated nucleotide sequences from thousands of homologous ultra-conserved elements (UCEs). Our phylogenetic analyses, using both concatenation and multispecies coalescent approaches, resulted in well-supported and highly congruent phylogenies that resolve the major lineages of rails and reveal several currently recognized genera to be polyphyletic. A fossil-calibrated time tree is well-resolved and supports the hypothesis that rails split into 2 major lineages (subfamilies Himantornithinae and Rallinae) ~34 mya, but clade age estimates have wide confidence intervals. Our results, combined with results of other recently published phylogenomics studies of rails and other Gruiformes, form the basis for a proposed classification of the Rallidae that recognizes 40 genera in 9 tribes.
Fragments of a Queer Feminist Rock and Pop History in Vienna
Authors: Fürnkranz Magdalena
Published: July 2021

The historical development of Viennese rock and pop music started with rock ’n’ roll in the 1950s, continued with beat music and the “dialect wave” in the late 1960s, punk in the 1980s, the popular Viennese electronic music scene in the 1990s, and is currently enjoying a renaissance of the “dialect wave.” Artists like the Rosée Sisters, Austria’s first all-female rock band founded in 1962, Topsy Girl, A-Gen 53, or SV Damenkraft were active in local music scenes. In retrospect, they are considered as exceptions in the historiography of Austrian popular music. This chapter discusses several feminist and queer artists and collectives in Austria, their position in popular culture, and in historical and geographical contexts. The author concentrates primarily on all-female bands, LGBTIQ+ artists, and queerpop projects to illustrate diverse approaches to music, feminism, and their position within the pop and rock music scenes in Vienna.
Birth and Childhood
Authors: Pache Corinne
Published: July 2021

The stories about the birth and childhood of Heracles tell of a hero who has the potential to be a protector and savior for gods and men, but also the most uncivilized of beings. His supernatural strength is both a boon and a disaster in waiting: it allows him to face wild animals and other threats, but, coupled with his lack of self-control, it is also what makes him dangerous to mankind. Already as a child, Heracles is the hero who “contains his own antithesis”; the greatest of the Greek heroes—the only one who transcends his half-mortal status to become a god—is also the most savage and threatening to human institutions.
Heracles as Ancestor
Authors: Patterson Lee E.
Published: July 2021

As he is ubiquitous in myth, Heracles is also ubiquitous in political myth-making, especially in his role as ancestor of communities and dynasties in the archaic through Hellenistic periods. Whether invoking his heroic qualities to enhance their own virtues or linking themselves to a Heraclid tradition to promote their own historical significance, such communities found Heracles to be useful in the context of political legitimization, kinship diplomacy, religion, and other areas. Examples include the creation and promotion of the Return of the Heraclidae by the Dorian regimes of the Peloponnese and attempts by individual Spartans to benefit personally from their putative Heraclid ancestry.
Labor III
Authors: Aston Emma
Published: July 2021

The Cerynean Hind serves to cast Heracles as a problematic hero. It is delicate and beautiful, and defeating it constitutes no great act of force or valor (though it does require fleetness of foot). Moreover, it is sacred to Artemis, and its capture therefore constitutes a serious religious transgression. This chapter examines the exploitation of this problematic quality in literature (such as Pindar) and art, and also discusses the localizations of the story, both in Hyperborea—the northern margin of Heracles’ travels—and the heartland of the Peloponnese. However, unlike the Stymphalian Birds, the Hind has no real place in the myth-historical identity of any Greek community.
Political Institutions and Intergenerational Ethics
Authors: Karnein Anja
Published: July 2021

This chapter reviews two prominent debates about institutions and intergenerational ethics, one held at the time of the founding of America and the other held today in the context of climate change. These two debates have more in common than may, at first, appear. On the face of it, the historical debate was about whether institutions, specifically the constitution, may bind future generations or whether the latter should be left maximally unencumbered. By contrast, proponents of climate change mitigation today would like institutions to be more inclusive of future generations’ interests. But, this chapter suggests, the new debate ought to be understood along the same lines as the old one, namely as being about avoiding disenfranchisement, that is, about preventing a situation in which previous generations determine too much of the context of future generations’ choices.
Intergenerational Justice and Equality
Authors: Wolf Clark
Published: July 2021

Egalitarians hold that people should be equal with respect to some morally relevant factor. While this does not imply that all inequalities should be eliminated, egalitarians do generally require that divergences from equality are presumptively worse unless special reasons render the resultant inequalities justifiable. In intergenerational contexts, egalitarianism faces special problems. While many ethicists and political theorists have emphasized the value of equality among contemporaries, there are reasons for skepticism about the value of equality between generations, or between persons who live at different times and whose lives may not even overlap. Strict principles of intergenerational equality would forbid progress and development that would improve circumstances in the future but would therefore create intergenerational inequalities by making later generations better off than earlier ones. This chapter considers aspects of the general case for egalitarianism, with specific focus on the value of equality between generations and over time.
Religion and Party Politics in India and Pakistan
Authors: Wilkinson Steven I.
Published: July 2021

Until the 1990s, religious influence on party politics in India and Pakistan was primarily through street protests and pressure on mainstream nonreligious parties rather than by religious parties winning power directly. In India, such influence was constrained by the secular constitutional structure and the dominant role of the Congress Party. In Pakistan, however, politically deinstitutionalized parties, weakened by military interference, have never been strong enough to take on the clerics. Instead, party leaders and military regimes have increasingly tried to co-opt or accommodate Islamist parties and pressure groups to strengthen their own positions. Civilian and military governments in the 1970s and 1980s institutionalized much of the Islamist agenda within the state in a way that now seems impossible to reverse. Ironically, the very fact that much of the Islamist agenda is now institutionalized, makes it difficult for Islamist parties to expand much beyond the 10–20% of the votes they now receive.India’s secular consensus, which many observers saw as its greatest achievement, has been profoundly disrupted by the decline of the Congress Party over the past three decades and the rise of the BJP, headed by the dominant figure of Prime Minister Narendra Modi, who has deep roots in the Hindu Nationalist Rashtriya Swayamsevak Sangh and its Hindu nationalist family (Sangh Parivar) of organizations. Modi, especially in his second term (2019–), has used his majority in parliament to try to radically remake India along Hindu nationalist lines, even though that was not central to his campaign platform, nor the reason why most development- and governance-minded voters elected him to office.
Reclaiming the Circular Economy
Authors: Anantharaman Manisha
Published: July 2021

Circular economy is a global sustainability strategy pursued by national governments and multinational corporations looking to reconcile ecological concerns with economic growth imperatives. It also finds expression in informal work and community-based initiatives in cities across Europe and Asia. As sites that bring together state and corporate-led initiatives with everyday circular practices and arrangements, the city is fertile ground to examine the environmental politics of the circular economy. Drawing on fieldwork examining informal recycling work in Indian cities, the author argues that in an eagerness to realize the “win-win” sustainability solutions that circular economy promises to businesses and the state, the actual socio-spatial work practices such as waste picking, sorting, and repair, which comprise resource circularity, are ignored. Attempts at establishing circular cities are undermined by competing urban sustainability agendas, the lack of recognition of informal expertise, and the fundamental contradiction between accumulative and redistributive goals. Reclaiming the circular economy from green growth will require transformational politics and grassroots involvement and resisting growth in favor of equity and ecological reparation.
Reforming Calvinism
Authors: Craigo-Snell Shannon
Published: July 2021

This chapter explores the rationalist slant of Calvinism, identifying its roots in the Reformation and its enmeshment with modern epistemology. Overly rational Calvinism participates in a disintegrated theological anthropology in which the mind is set as guard over the unruly emotions, will, and body. In conversation with performance theory, the author argues that the Reformed emphasis on texts has not served its intended function as a safeguard from superstition and idolatry, but rather contributed to myriad forms of oppression. A more integrated vision of the self, embodied in whole-personed religious disciplines, would be more consistent with Calvin’s theology, with the goals of the Reformation, and with the biblical tradition of prophets as those who resist religious abuse and idolatry. In particular, practices of prayer and intentional formation to instil Christian affections could continue the ongoing reformation of Calvinist traditions.
Calvinism among Seventeenth-Century English Puritans
Authors: Cooper Tim
Published: July 2021

This chapter considers the broad historical and intellectual developments that contributed to the ‘crisis of Calvinism’ in seventeenth-century England and examines how the Puritans responded and adapted to those changes. Put simply, they could abandon, moderate, or defend Calvinism. The specific example of John Owen and Richard Baxter is used to illustrate some of the mechanisms at work in this process of adaptation. Alarmed by growing Arminianism and Socinianism, Owen tried to shore up Calvinism; alarmed by Antinomianism, Baxter modified his Calvinism to incorporate a place for conditions and human agency in the process of salvation. An abbreviated survey of each man’s career will demonstrate how personal experience and historical contingency can shape doctrinal perspectives, and how they played a part in the decline of Calvinism even among the English Puritans.