bluuebunny/crossref_metadata_2025 huggingface dataset:
MicroRNA-200b reduced ZEB1 to inhibit cell proliferation and migration in human gastric cancer
Authors: Chen He , Liu Pengcheng , Wang Lei , Yu Yanxia , Zhao Yan , Cai Yihong , Wang Zhongxin , Zhang Min
Published: November 2019

BACKGROUND Gastric cancer (GC) is one of the most common malignant cancers, with high morbidity and mortality rates worldwide. The present study was to explore whether miR-200b is a tumor suppressor in GC and to unveil the potential mechanisms.METHODS Levels of c-Myc, Cyclin D1, MMP-3 and MMP-9 expression were detected respectively by q-PCR and Western blot assay. BrdU proliferation assay, Cell cycle analysis and Wound-healing were used to study the role of miR-200b with inhibitor, mimics or ZEB1-RNAi in TGF-β1-treated SGC-7901/DDP cells.RESULTS Compared with the paracancerous tissues, miR-200b was decreased in GC patients and SGC-7901/DDP cells. Lower level of miR-200b induced by its inhibitor promoted TGF-β1-treated SGC-7901/DDP cells proliferation and migration, and increased the levels of c-Myc, Cyclin D1, MMP-3, and MMP-9. Interestingly, miR-200b mimics and ZEB1-RNAi were able to reduce the proliferation and migration of TGF-β1-induced SGC-7901/DDP cells as well as their levels of c-Myc, Cyclin D1, MMP-3 and MMP-9. In addition, ZEB1 was indeed the potential target of miR-200b identified by dual luciferase reporter gene assay.CONCLUSION Taken together, our findings suggest that miR-200b be likely to play an important role in activating TGF-β1-induced SGC-7901/DDP cells and perform as a tumor suppressor by targeting ZEB1 in GC.
Effect of Endogenous Expression of the Laminin α5 Chain on Chemotherapy Resistance of Colorectal Cancer Cells
Authors: Raigorodskaya M.R , Belyakova G.A. , Turchinovich A.
Published: November 2019

The expression of the LAMA5 gene encoding the laminin α5 chain has been inhibited in the line HT29 cells. The treatment with 5-fluorouracil (5FU) and regorafenib (RF) showed that the knockdown of LAMA5 increases the sensitivity of the HT29 cells to 5FU by 2.2 times and does not affect their sensitivity to RF. The data of transcriptome analysis indicate that the observed changes in the sensitivity to 5FU may be caused by an activation of signaling pathways of the endoplasmic reticulum stress in the HT29 cells. In the case of RF, this effect can be compensated by a 2-fold decrease in the expression of the main RF transporter in HT29 cells.

apoptosis, colorectal cancer, laminins, drag resistance, knockdown, regorafenib, endoplasmic reticulum stress, 5-fluorouracil, laminin α5 chain, endogenous expression, HT29, LAMA5, UPR.

The study was supported by the Russian Science Foundation (Project 17-14-01338).
Possible health impacts due to animal and human fecal pollution in water intended for drinking water supply of Rio de Janeiro, Brazil
Authors: Bianco Kayo , Albano Rodolpho Mattos , de Oliveira Samara Sant'Anna , Alves Nascimento Ana Paula , dos Santos Thaís , Clementino Maysa Mandetta
Published: November 2019

Fecal matter is considered as one of the worst pollutants in waterbodies due to the potential spread of waterborne diseases. This study aimed to determine the host-specific fecal contamination in two Brazilian watersheds and to predict the possible impacts on human health. Fecal sources were enumerated using host-specific genetic markers to swine (16S rRNA), human and bovine (archaeal nifH), and equine (archaeal mcrA). A single cycling condition was established for four markers aiming to decrease the analysis time. Fifteen samples from São João watershed (75%) and 25 from Guandu (62.5%) presenting Escherichia coli enumeration in compliance with Brazilian guidelines (<1,000 MPN/100 mL) showed the human marker. Furthermore, the bovine, swine, and equine markers were present in 92% (59/64), 89% (57/64), and 81% (52/64) of the water samples, respectively. The molecular markers proposed for qPCR in our study were sensitivity and specific enough to detect host-specific fecal pollution in all samples regardless of E. coli levels reaffirming the low correlation among them and supporting their use in water quality monitoring programs. To our knowledge, this is the first study using this approach for quantification of nifH, mcrA, and rrs gene-associated human and animal fecal pollution in waters intended for drinking water supply in Brazil.
Advances in the Detection, Mechanism and Therapy of Chronic Kidney Disease
Authors: Dong Yu , Qu Xiaosheng , Wu Gang , Luo Xiangdong , Tang Botao , Wu Fangfang , Fan Lanlan , Dev Sooranna , Liang Taisheng
Published: November 2019

Chronic Kidney Disease (CKD) is characterized by the gradual loss of renal mass and functions. It has become a global health problem, with hundreds of millions of people being affected. Both its incidence and prevalence are increasing over time. More than $20,000 are spent on each patient per year. The economic burden on the patients, as well as the society, is heavy and their life quality worsen over time. However, there are still limited effective therapeutic strategies for CKD. Patients mainly rely on dialysis and renal transplantation, which cannot prevent all the complications of CKD. Great efforts are needed in understanding the nature of CKD progression as well as developing effective therapeutic methods, including pharmacological agents. This paper reviews three aspects in the research of CKD that may show great interests to those who devote to bioanalysis, biomedicine and drug development, including important endogenous biomarkers quantification, mechanisms underlying CKD progression and current status of CKD therapy.
Synthesis and Evaluation of N-substituted (Z)-5-(Benzo[d][1,3]dioxol-5- ylmethylene)-2-Thioxothiazolidin-4-one Derivatives and 5-Substituted- Thioxothiazolidindione Derivatives as Potent Anticonvulsant Agents
Authors: Dong Shiyang , Liu Yanhua , Xu Jun , Hu Yue , Huang Limin , Wang Zengtao
Published: November 2019

Background:

Epilepsy is a serious and common neurological disorder threatening the
health of humans. Despite enormous progress in epileptic research, the anti-epileptic drugs present
many limitations. These limitations prompted the development of more safer and effective AEDs.

Methods:

series of N-substituted (Z)-5-(benzo[d][1,3]dioxol-5-ylmethylene)- 2-thioxothiazolidin-4-
one derivatives and 5-substituted-thioxothiazolidindione derivatives were designed, synthesized and
tested for anticonvulsant activity against maximal electroshock (MES) and subcutaneous pentylenetetrazole
(scPTZ). Neurotoxicity was determined by the rotarod test.

Results:

Among them, the most potent 4e displayed high protection against MES-induced seizures
with an ED50 value of 9.7 mg/kg and TD50 value of 263.3 mg/kg, which provided 4e with a high protective
index (TD50/ED50) of 27.1 comparable to reference antiepileptic drugs. 4e clearly inhibits the
NaV1.1 channel in vitro. The molecular docking study was conducted to exploit the results.

Conclusion:

Stiripentol is a good lead compound for further structural modification. Compound 4e
was synthesized, which displayed remarkable anticonvulsant activities, and the NaV1.1 channel inhibition
was involved in the mechanism of action of 4e.
Спектрально-кинетическое исследование фотохромных систем на основе наноструктур графена и его оксида
Authors: Венидиктова О.В. , Барачевский В.А. , Хузин А.А. , Туктаров А.Р. , Шиенок А.И. , Зайченко Н.Л.
Published: November 2019

Проведено сравнительное спектрально-кинетическое исследование взаимодействия тиолзамещенных молекул диарилэтена и спирооксазина с наночастицами графена и нанопластинками оксида графена. Выявлены различия в фотохромных превращениях соединений, контактирующих с поверхностью углеродных наночастиц в зависимости от структуры соединений и природы наночастиц, свидетельствующие о химическом и физическом взаимодействии молекул фотохромных соединений с поверхностными группами углеродных наноструктур. Ключевые слова: фотохромизм, спирооксазин, диарилэтен, графен, диоксид графена, спектроскопия, кинетика.
Review of Hridroga W.S.R. to the Ischemic Heart Disease
Authors: Uikey Rajesh , Patel Diwakar
Published: November 2019

Hridroga (Heart disease) is very common in present scenario due to the sedentary life style and increase psychosocial stress. The major causative factors for heart problems are cigarette smoking, tobacco chewing, alcohol consumption, junk foods and obesity. According to WHO Ischemic heart disease or Coronary artery disease is the major causes of mortality. Therefore, it is needed to explore knowledge on heart disease time to time. The main purpose of this article is to promote the awareness about the heart disease, so prevalence of such problem can be reduced by avoiding risk factors.

Keywords: Hridroga, Hritshool, Heart disease, Ayurveda, IHD (Ischemic Heart Diseases).
EDUCAÇÃO AMBIENTAL E SUSTENTABILIDADE DOS RECURSOS HÍDRICOS NO COLÉGIO ESTADUAL GONÇALO ROLLEMBERG LEITE
Authors: Cunha Simone Neves , Carvalho Marcia Eliane Silva
Published: November 2019

A presente pesquisa-ação teve como objetivo promover ações de educação ambiental, com foco na água, junto à comunidade do Colégio Estadual Professor Gonçalo Rollemberg Leite em Aracaju-SE. Parte-se do pressuposto de que é necessário repensar as relações estabelecidas entre a sociedade e o meio ambiente e de que a escola é um espaço de extrema importância para a formação de sujeitos preocupados em se engajar na formação de uma sociedade sustentável. Neste sentido, buscou-se verificar a postura da comunidade escolar em sua relação com o meio ambiente e mais especificamente com relação a utilização da água; Sensibilizar os alunos quanto ao uso racional da água; Desenvolver uma ação interdisciplinar, integrando alunos e professores em prol da sustentabilidade dos recursos hídricos; Divulgar as ações junto à comunidade escolar como forma de envolver mais pessoas no processo de sensibilização para a sustentabilidade dos recursos hídricos. Para tanto foram realizadas: rodas de conversa; produção de cartazes; exibição de vídeos educativos; visita a exposição; atividade de campo no entorno e dentro do ambiente escolar; confecção de material pedagógico sugerido pelos alunos, que foi utilizado no dia da culminância. As ações desenvolvidas evidenciaram um maior compromisso dos envolvidos para com o meio ambiente e uma maior autonomia dos alunos na tomada de decisões e  na busca de soluções para os problemas encontrados. Os mesmos demonstraram o interesse na criação de um clube de protagonismo em educação ambiental e no reuso das águas para a promoção da sustentabilidade dos recursos hidricos no ambiente escolar.
Estudio del pH y niveles de flúor en saliva y placa dental en niños con dentición permanente temporaria y mixta
Authors: Joison a. , Gargantini p.
Published: November 2019

Las carieses la enfermedad oral que mayor destrucción causa a los tejidos dentales, se da gracias a la conjugación de varios factores, uno de ellos es la alteración de pH salival. En los niños, el pH desempeña un importante papel en la remineralización del esmalte dental. La concentración de fluoruro en el esmalte y zona pulpar de la dentina es relativamente alta. Él fluoruro juega un papel muy importante, inclinando el proceso hacia la remineralización y desarrollo de una estructura dental más resistente al ataque de los ácidos. OBJETIVO: La presente investigación tiene como objetivo estudiar los valores del pH y flúor salival y paca biofilm dental relacionado a los diferentes tipos de dentición. POBLACIÓN Y MÉTODO: Se estudiaron 28 pacientes de ambos sexos y edades entre 3 a 12 años que concurrieron a la clínica odontológica de la Universidad Católica de Córdoba. Estudio aleatorio, descriptivo y transversal. Se analizó pH, capacidad buffer, niveles de flúor. La dentición fue clasificada como temporaria, permanente y mixta. RESULTADOS: Se observó mayor cantidad de flúor en placa dental, alta lactancia materna, buena capacidad buffer, con niveles elevados de bicarbonato. Se encontró correlación positiva entre los niveles de flúor en placa dental y pH salival (r: 0.40, p < 0.05). En análisis de varianza (ANOVA II) encontró diferencias significativas en los niveles de flúor en saliva respecto a placa dental en el sexo masculino 0.013 ± 0.002 vs 0.047 ± 0.016; p < 0.05. CONCLUSIÓN: El análisis de las muestras mostró correlación positiva entre pH y flúor en saliva.
Sighting rates and prey of Minke Whales (Balaenoptera acutorostrata) and other cetaceans off Cormorant Island, British Columbia
Authors: Towers Jared R. , McMillan Christie J. , Piercey Rebecca S.
Published: November 2019

From June to August 2012, we conducted over 500 h of visual surveys from Cormorant Island, British Columbia, to determine behaviour and habitat use patterns of nearby cetaceans. Seven species were documented, but Minke Whales (Balaenoptera acutorostrata) were by far the most common and were observed lunge feeding at the surface on 15 occasions. In addition, this species was documented surface lunge feeding on Pacific Herring (Clupea pallasi) and Pacific Sand Lance (Ammodytes personatus) on 32 occasions during vessel-based cetacean surveys around Cormorant Island between 2010 and 2014. Although Minke Whales are relatively uncommon in British Columbia, these results indicate that they can regularly be found in specific feeding areas during the summer.
Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels
Authors: Taddeo Evan P. , Alsabeeh Nour , Baghdasarian Siyouneh , Wikstrom Jakob D. , Ritou Eleni , Sereda Samuel , Erion Karel , Li Jin , Stiles Linsey , Abdulla Muhamad , Swanson Zachary , Wilhelm Joshua J. , Bellin Melena D. , Kibbey Richard G. , Liesa Marc , Shirihai Orian S.
Published: November 2019

Fasting hyperinsulinemia precedes the development of type 2 diabetes. However, it is unclear whether fasting insulin hypersecretion is a primary driver of insulin resistance or a consequence of the progressive increase in fasting glycemia induced by insulin resistance in the prediabetic state. Herein, we have discovered a mechanism that specifically regulates non–glucose-stimulated insulin secretion (NGSIS) in pancreatic islets that is activated by nonesterified free fatty acids, the major fuel used by β-cells during fasting. We show that the mitochondrial permeability transition pore regulator cyclophilin D (CypD) promotes NGSIS, but not glucose-stimulated insulin secretion, by increasing mitochondrial proton leak. Islets from prediabetic obese mice show significantly higher CypD-dependent proton leak and NGSIS compared with lean mice. Proton leak–mediated NGSIS is conserved in human islets and is stimulated by exposure to nonesterified free fatty acids at concentrations observed in obese subjects. Mechanistically, proton leak activates islet NGSIS independently of mitochondrial ATP synthesis but ultimately requires closure of the KATP channel. In summary, we have described a novel nonesterified free fatty acid–stimulated pathway that selectively drives pancreatic islet NGSIS, which may be therapeutically exploited as an alternative way to halt fasting hyperinsulinemia and the progression of type 2 diabetes.
Spin-off av EØS? Norge og europeisk utenriks-, sikkerhets- og forsvarssamarbeid
Authors: Svendsen Øyvind , Rieker Pernille
Published: November 2019

Norge har samarbeidet tett med EU om utenriks-, sikkerhets- og forsvarspolitikk siden slutten av 1990-tallet. Det er naturlig å se på dette samarbeidet som supplement til – eller spin-off av – EØS-avtalen. Når dette feltet nå er i endring med nye ambisiøse initiativer, samt at EUs forhold til tredjeland generelt vil revurderes som følge av brexit, vil dette få konsekvenser for Norges tilknytning til EU på dette området. Blant annet ser vi antydninger til det vi her kaller en mulig «EØS-ifisering» av dette feltet. Fokusbidraget analyserer tre utviklingstrekk og mulige konsekvenser av disse for Norge. Det første omhandler EUs beslutninger om det som skjer innenfor EU, nemlig PESCO og beslutningen om å styrke det felles europeiske forsvarsmarkedet. Det andre omhandler initiativer utenfor EU, som det franske europeiske intervensjonsinitiativet (EI2), som må ses i sammenheng med det første. Det tredje er brexit, som etter planen skal ta Storbritannia inn i «tredjelandsklubben», der Norge er en sentral aktør i dag. Hvilke konsekvenser får de nye initiativene tatt innenfor og utenfor EU, for Norge, og hva gjør brexit med Norges handlingsrom som utenriks-, sikkerhets- og forsvarspolitisk samarbeidspartner med EU?
Abstract in English:Spin-off of the EEA? Norway and the European Foreign, Security and Defense PolicyNorway has cooperated closely with the EU on foreign, security and defense policy since the late 1990s. It seems fitting to look at this cooperation as a supplement to – or spin-off of – the EEA agreement. As this field is now changing, with new ambitious initiatives, and that the EU’s relations with third countries will generally be reassessed as a result of Brexit, this will have consequences for Norway’s relations with the EU in this area. Among other things, we see trends towards what we label a possible “EEA-isation” of this field. This focus article analyses three developments and potential consequences for Norway. The first concerns EU decisions on what is happening within the EU, namely PESCO and the decision to strengthen the common European defense market. The second concerns initiatives outside of the EU, such as the French European Intervention Initiative (EI2), which must be seen in relation to the first. The third is Brexit, which is an attempt to take the UK into the “third country club” where Norway so far has been the key player. What are the consequences of the new initiatives taken within and outside the EU for Norway, and what does Brexit do to Norway’s agency as a partner to the EU in the area of foreign, security and defense policy?
Introduksjon: 25 år med hardt EØS-arbeid: Fra venterom til permanent oppholdssted?
Authors: Sverdrup Ulf
Published: November 2019

I denne introduksjonsartikkelen viser Ulf Sverdrup at Norge er blitt forandret gjennom EØS-avtalen, men også hvordan den med sine mangler og svakheter i all hovedsak har vært en suksess, og at Norges avtaler i det store og hele har ivaretatt norske interesser. Flertallet har ganske enkelt funnet alternativene til EØS-avtalen mer usikre og mindre attraktive. Forfatteren ser nærmere på hvordan en avtale som opprinnelig var ment som et venterom for medlemskap, kunne bli et permanent oppholdssted. Mens selve hoveddelen av EØS-avtalen knapt er endret, har det samtidig vært betydelig dynamikk og endring, både gjennom geografisk utvidelse og fordypning av samarbeidet. I denne artikkelen skisseres noen av de viktigste utviklingstrekkene i perioden. Samtidig introduseres de ulike bidragene til spalten.

Abstract in English:Introduction: 25 Years of Hard EEA Work: From Waiting Room to Permanent Feature?In this introductory article, Ulf Sverdrup shows that Norway has been transformed through the EEA Agreement. In spite of its shortcomings and weaknesses, the EEA Agreement has been successful as it has provided a stable framework for cooperation with the EU and has safeguarded Norwegian interests. Throughout the 25-year period, the political majority have simply found the alternatives to the EEA Agreement more uncertain and less attractive. The author examines how an agreement that was originally intended as a waiting room for membership could end up becoming a permanent feature. It is also observed that while the main part of the EEA Agreement has remained largely unchanged, there has been considerable dynamism and change in the agreement, both through the geographical expansion of the EEA and through the deepening of the cooperation. This article outlines and discusses some of the most important dynamics and introduces the other contributions to this special issue.
Holdninger til EØS-avtalen etter 25 år: Stor oppslutning, men liten kunnskap
Authors: Sverdrup Ulf , Svendsen Øyvind , Weltzien Åsmund
Published: November 2019

I anledning EØS-avtalens 25-årsjubileum gjennomførte NUPI og Sentio i januar 2019 en opinionsundersøkelse i den norske befolkningen for å kartlegge nordmenns holdninger til EØS-avtalen samt deres kunnskaper og vurderinger i tilknytning til avtalen og mulige alternativer til den. Resultatene fra undersøkelsen viser at det er stor støtte til EØS-avtalen i befolkningen. Samtidig viser den også at kunnskapsnivået om EØS-avtalen er lavt i hele befolkningen, men særlig blant de unge. Videre viser resultatene at dersom EØS-avtalen skulle opphøre, ville Norge neppe kunne forvente noen ny bred konsensus om en alternativ tilknytningsform. I dette bidraget går Svendsen, Sverdrup og Weltzien gjennom resultatene fra opinionsundersøkelsen og diskuterer hva de impliserer for norsk europapolitikk.
Abstract in English:Attitudes to the EEA Agreement After 25 Years: Considerable Support, Little KnowledgeOn the 25th anniversary of the EEA Agreement, NUPI and Sentio conducted a public opinion poll in January 2019 in the Norwegian population to survey Norwegians’ attitudes to the EEA Agreement, as well as their knowledge and assessments of the agreement and possible alternatives to it. The results of the survey show that there is considerable support for the EEA agreement in the population. At the same time, it also shows that the level of knowledge about the EEA Agreement is low in the entire population, but especially among the youngest respondents. Furthermore, the results show that if the EEA Agreement were to cease to exist, Norway could hardly expect any new broad consensus on an alternative form of association. In this contribution, Svendsen, Sverdrup and Weltzien review the results of the opinion poll and discuss the results and what they imply for Norwegian European policy.
Analytical study of heat transfer in thermohydrocyclon for commercial dewaxing of oil
Authors: Шишкин Николай Дмитриевич , Shishkin Nickolai Dmitrievich , Марышева Марина Александровна , Marysheva Marina Aleksandrovna
Published: November 2019

The article considers modernization of the design of thermohydrocyclone (THC), where cooling, solidification and heating mechanisms are carried out in one continuous process. This reduces the time of the complete cycle of oil removal from paraffin, increases the productivity and efficiency of the plant. The technological scheme of continuous operation THC is presented. The general factors and simplifying allowances for mathematical modeling of phase transition processes (melting and solidification) are considered. Differential equations for heat transfer in the course of paraffin melting and solidification in a conical layer have been solved analytically. Formulas for determining thickness of the conical layer of the new phase, time of formation of a new solid phase, and average density of the heat flow in the conical layer on a THC wall have been derived. The effect of centrifugal inertia forces is taken into account. The formulas for calculating the basic parameters are summarized in the form of power criterion equations linking Fourier criteria (Fo), Kosovich criteria (Ko) and Pomerantsev criteria (Po) under the quasiconductive non-stationary heat exchange in THC.
Problems of constructing broadband radio access systems of mobile radio communication
Authors: Типаков Василий , Tipakov Vasily Sergeevich , Яковлев Тимур , Yakovlev Timur Aleksandrovich
Published: November 2019

The article is focused on the problem of degrading the signals of broadband 3G / 4G mobile radio access systems in places of subscribers clustering and in so-called “dead zones”. The analysis of the actual principles of building mobile networks has been carried out, the main disadvantages of the approaches to the development of cellular networks have been identified. The current trend of building macro cells in the urban environment has lost its effectiveness due to the increasing frequencies used; it has to be replaced by a fundamentally new way of planning mobile networks. A new principle of providing access to mobile communications “from inside to outside” is proposed, which takes into account the needs of a large number of subscribers in the premises. It is based on setting the maximum number of internal base stations fully meeting the needs of internal network users. Such a distinction will positively affect all subscribers and improve the experience from using the high-quality services of the mobile operators, which will result in increasing the economic performance
Analysis and assessment of effective utilization of business fixed assets
Authors: Дубинина Наталья Александровна , Dubinina Nataliya Aleksandrovna , Винярский Дмитрий , Vinyarsky Dmitry Viktorovich
Published: November 2019

The paper focuses on the development of small and medium-sized deposits accompanied by implementing the investment design solutions, new expensive equipment and technologies. Further progressive development of the oil and gas complex depends on the implementation of measures supporting the operability of oil pipeline systems, the modernization and reconstruction of oil and gas complex enterprises. The main reasons for decreasing economic efficiency of the oil and gas complex are the outdated oil production technologies, as well as the obsolete drilling equipment. To make timely decisions and take measures to restore and improve equipment performance, a comprehensive assessment of the technical condition of the equipment is required, including not only an assessment of the safe operation of equipment and the possibility of extending service life, but also evaluating of the technological condition, the possibility and necessity of its restoration in terms of evaluating the efficient operation of the equipment.
ANTIOXIDANT ACTIVITY OF ETHYL ACETATE EXTRACT OF NUTMEG (Myristica fragrans Houtt) STEM BARK
Authors: Maulana Ilham , Ginting Binawati , Nurdin Nurdin , Fakri Saiful
Published: November 2019

Antioxidant activity test for the extract of ethyl acetate nutmeg stem bark (Myristica fragrans Houtt) was carried out using 2,2-diphenyl-1picrylhydrazil (DPPH). The test results of antioxidant activity of ethyl acetate nutmeg stem bark extract with DPPH method at a concentration of 25 ppm, 50 ppm and 100 ppm obtained IC50 value = 68.14 ppm with IC50 value of vitamin C (as positive control) 3.657 ppm. The results of column chromatographic separation of ethyl acetate nutmeg stem bark extract obtained 5 combined fractions namely MFEK 1, MFEK 2, MFEK 3, MFEK 4 and MFEK 5. The test results of the fraction antioxidant activity in a good category were the MFEK 1 fraction. The MFEK 2 fraction to MFEK 5 showed an antioxidant activity lower than compared  to the ethyl acetate extract. This shows that the ethyl acetate nutmeg stem bark extract has a better inhibitory activity, because there are several active compounds contained in the extract which can inhibit free radicals, so the IC50 value of the extract is better than the fractions.
Hubungan Pelanggaran Kontrak Psikologis dan Kepribadian Tipe A dengan Intensi Turnover Karyawan Bank
Authors: Ramadhany Ni Putu Ayu Saraswati , Simarmata Nicholas
Published: November 2019

One of the common phenomena in organization is the failure in fulfilling promise in retention management, which leads to psychological contract violation and triggers turnover intention. Other phenomenon is difference of employees personality. Employees with type A personality have characteristics which make them tend to react negatively and have high turnover intention. Analogously with Wattson Wyatt survey (2007) that found turnover level among bank employees reached 6,3%-7,5% which was high compared to other industries, it becomes important to study turnover intention among bank employees. According to that, researcher wants to find relationship between psychological contract violation and type A personality on turnover intention of bank employees, simultaneously and individually.   Subjects in this research are 52 employees of bank X in Denpasar. Method used in this research is correlational study. Data are collected by questionnaire. Turnover intention questionnaire has 23 valid items and its reliability coefficient is 0,896. Psychological contract violation questionnaire has 18 valid items and its reliability coefficient is 0,870. Type A personality questionnaire has 35 valid items and its reliability coefficient is 0,965. Data are normal and linear. Multiple regression and partial correlation are run for data analysis. The result of this research finds positive significant relationship between psychological contract violation and type A personality on turnover intention. The reliability coefficient is +0,863. The value of coefficient of determination is 0,744, which shows psychological contract violation and type A personality has 74,4% contribution to turnover intention.  Type A personality has positive significant relationship with turnover intention. The reliability coefficient is 0,556. There is no relationship between psychological contract violation and turnover intention.   Keywords: turnover intention, psychological contract violation, type A personality, bank employees
Peran Efikasi Diri dan Dukungan Sosial Teman Sebaya Terhadap Penyesuaian Diri Mahasiswa Tahun Pertama Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Udayana
Authors: Sasmita Ida Ayu Gede Hutri Dhara , Rustika I Made
Published: November 2019

Adjustment is an important mental aspects that determine a person's success in dealing with various problems in his life. The mental aspect is related to one's belief in the ability to control various obstacles and use your own potential. In addition, the mental aspect is also strongly associated with a positive response from the environment.The purpose of this research is to find out the role of self efficacy and peers social support toward personal adjustment in Medical School Udayana University. Subjects in this research were 137 first-year students Medical School Udayana University. The instruments in this research were self-efficacy scale, peers social support scale and personal adjustment scale. The result of multiple regression analysis shows R=0,605 (F=38,776; p<0,05) thus it can be stated that both self-efficacy and peers social support together contributes to personal adjustment. Determination coefficient = 0,367, which means the effective contribution of self-efficacy and peers social support to personal adjustment is 36,7%. Standardized beta coefficient of self-efficacy is 0,457 (t=5,935; p<0,05) thus it can be stated self-efficacy contribute to personal adjustment. Standardized beta coefficient of peers social support is 0,242 (t=3,141; p<0,05) thus it can be stated peers social support contribute to personal adjustment.   Keywords: self-efficacy, peers social support, personal adjustment, first-year student.
La formación de profesores en Francia
Authors: Chabannes Rolando
Published: November 2019

En su forma y modalidades institucionales actuales, el sistema francés de formación de profesores tiene menos de 15 años.Las instituciones que tienen a su cargo lo esencial de esta formación fueron creadas entre 1980 y 1990, se trata de: Las Misiones Acádemicas para la Formación del Personal de la Educación Nacional (MAFPEN) en lo que se refiere a la formación continua y los Institutos Universitarios de Formación de Maestros (IUFM) para lo que tiene que ver con la formación inicial.
Opportunities and Risks of Technological Enhancement of the Monitoring System of Inter-Ethnic and Inter-Confessional Relations and Early Prevention of Conflict Situations
Authors: Erokhina E. A.
Published: November 2019

The paper considers the risks of implementation of the technocratic model of national policy for local and regional communities. Two groups of socio-cultural determinants that govern the emergence of projects for technological enhancement of the monitoring system of the interethnic relations are highlighted: sociotechnical and managerial fictions. The example of introduction of artificial intelligence system into the procedures of information collection and analysis in the system of interethnic relations monitoring shows the contradiction between the growing influence of the techno-science and the underestimation of risks caused by the implementation of innovations. The paper also justifies the important role of institutions of public expertise in assessing the risks facing the society due to the implementation of projects of innovative and human development.
Points of Social-Economic Growth of the Agro-Industrial Complex of the Russian Federation
Authors: Shmakov V. S.
Published: November 2019

The article analyses the problem of determining the factors, rates and directions of social and economic growth in the agrarian sphere of the Russian Federation. To ensure the sustainable development of the agrarian economy and rural local communities, the most significant points of agricultural development have been identified: the state agrarian policy, innovation and technological development, the creation of a cluster structure of production, and the formation of human capital. An analysis of the influence of growth points on the development of the agro-industrial complex is provided. The introduction of new machinery and technologies, attraction of investments can contribute to socio-economic and sociocultural transformations of rural local communities, qualitative and quantitative changes in the life of the village. A comprehensive approach to assessing the current state of development of the Russian village is proposed.
Institutional Dynamics of the Agricultural Sector as a Factor of Transformation of Rural Communities
Authors: Zazulina M. R.
Published: November 2019

The paper shows dynamics of the institutions of the agrarian sector in the post-Soviet period and provides the characteristics of the economic and social consequences of these changes for the development of rural communities. It was revealed that in the agrarian institutions two different components are present, the archaic and the modern, which structure the life of the rural society. The archaic component is represented by the institution of private subsidiary farms, is associated with the minimization of all life support processes and ensures the survival of the village in times of crisis. The modern component, represented by agricultural organizations and farming, is associated with the development of innovative agricultural production, and not with the support of rural communities. The development of innovative forms of management leads to a weakening of the social and economic potential of personal subsidiary plots and the unsustainable dynamics of the rural society.
Экспериментальное и теоретическое исследование электронной структуры фталоцианинов цинка ZnPc и ZnPcF16
Authors: Семушкина Г.И. , Мазалов Л.Н. , Лаврухина С.А. , Гуляев Р.В. , Клямер Д.Д. , Басова Т.В.
Published: November 2019

Исследовано электронное строение фталоцианинов цинка ZnPc и ZnPcF16 рентгеноспектральным и рентгеноэлектронным методами. Проанализированы экспериментальные и теоретические параметры энергетического спектра и парциального состава ВЗМО молекул этих соединений. Показано, что граничная высокоэнергетическая область высших занятых молекулярных орбиталей (ВЗМО) ZnPc состоит из вкладов атомных орбиталей (АО) 2рπ атомов азота неэквивалентных групп (Nα, Nβ) и из 2рπ периферийных атомов углерода (Сβγδ) с участием 3d-орбиталей цинка как π-типа (3dyz, 3dz2), так и σ-типа (3dxy). Установлено, что атомы фтора и центральный атом цинка в ZnPcF16 взаимодействуют друг с другом посредством образования делокализованных π-орбиталей с участием pπ-орбиталей атомов углерода, принадлежащих группам α, β, γ, δ, а также pπ-орбиталей атомов азота групп α и β. ВЗМО ZnPcF16 построена главным образом из 2рx-, 2рy-АО азота (Nα и Nβ) и углерода (Сβ и Сγδ) с незначительным участием 3dxz, yz-орбитали цинка.
Упаковочный полиморфизм на примере 5-гидрокси-1-(4-метилбензил)-3-хлор-4-[(4-хлорфенил)сульфанил]-1,5-дигидро-2Н-пиррол-2-она: кристаллографическое, термохимическое и спектроскопическое исследование
Authors: Герасимова Д.П. , Сайфина А.Ф. , Захарычев Д.В. , Вандюкова И.И. , Файзуллин Р.Р. , Курбангалиева А.Р. , Лодочникова О.А.
Published: November 2019

Два упаковочных полиморфа 5-гидрокси-1-(4-метилбензил)-3-хлор-4-[(4-хлорфенил)сульфанил]-1,5-дигидро-2Н-пиррол-2-она исследованы методами монокристальной и порошковой рентгеновской дифрактометрии, ИК спектроскопии и дифференциальной сканирующей калориметрии. Принципиальное значение в формировании общего для обеих модификаций супрамолекулярного мотива имеют классические водородные связи и Cl⋯O взаимодействия. Различие заключается в способе стыковки 2D слоев: «параллельный» в триклинной модификации и «паркетный» в моноклинной. Показано, что высокая степень подобия структурной организации кристаллических решеток, характерная для упаковочных полиморфов, может сочетаться с существенной разницей в их энергетике, а также с высоким потенциальным барьером трансформации метастабильного полиморфа в стабильный.
PROBLEMATIKA PENGATURAN CYBERSTALKING (PENGUNTITAN DI DUNIA MAYA) DENGAN MENGGUNAKAN ANNONYMOUS ACCOUNT PADA SOSIAL MEDIA
Authors: Octora Rahel
Published: November 2019

The internet is a new world where humans interact, without limitation of distance and time. In the real world, as legal subjects, everyone must have a clear identity, proof of identification, so that the state can recognize it and the law can be upheld against it, as well as the law can protect their rights. Social media which is currently developing, allows everyone to appear and interact in cyberspace either by showing their true identity, or by using fake identities, or even interacting without identity (annonymous). Easily each person can create more than one e-mail account, which can be used to create more than one social media account. Although the creation of e-mail and social media accounts is through the cell phone number verification stage, this does not solve the problem because anyone can easily have multiple cellphone numbers. A person in cyber world can be an anonymous subject and take various actions that harm others, including stalking others. Stalking, done by the person behind an anonymous account is an annoying action, has not been regulated clearly in Indonesian. This paper is the result of a normative juridical study. Result of this research is: criminal law regulation system in Indonesia regulated cyberstalking as long as the action consist of delivery of illegal contents such as threats, obscene content and insults. Further regulation is still needed, especially regarding law enforcement mechanisms for perpetrators that are difficult to reach due to the use of the anonymous account.
Communal energy in agricultural sphere: state, problems and prospects
Authors: Kharlamova Natalya Anatolyevna
Published: November 2019

Particular attention in the housing and communal services of the country's agro-industrial complex is given to the state and conditions of operation of heat supply systems. The article analyzes and draws conclusions that are based on specific actual performance and accident rates of elements of heat supply systems. Poor performance of centralized systems made it necessary to consider the possibility of using non-traditional sources for heat supply systems, their technical and economic indicators and investment attractiveness.
Comparison of Secnidazole and Fenbendazole for the Treatment of Asymptomatic Giardia Infection in Dogs
Authors: Ruiz Jhon-Didier , Ramírez Gloria P , Múnera Ana M , Arroyave Carlos , Castaño Laura , López Pablo
Published: November 2019

The objetive of this study was to compare a single dose of secnidazole versus multiple doses of fenbendazole for the treatment of dogs with asymptomatic Giardia infection. Materials and methods: Twenty-four asymptomatic dogs with a positive test result for Giardia spp were randomized in two equal groups to receive a single dose of secnidazole at 30 mg/kg PO, or fenbendazole at 50 mg/ kg PO q24h for 3 days. Hematological parameters were evaluated before and 8 days after treatment, and feces were re-examined at days 8, 15, and 30 post-treatment by fecal flotation and antigen test. Results: The number of positive dogs in the fenbendazole group was: 1 (day 8) and 3 (days 15 and 30). In the secnidazole group, the number of positive cases were: 4 (day 8), 3 (day 15), and 1 (day 30).  Conclusion: Treatment with secnidazole or fenbendazole, were effective between 75% and 92% to eliminate the excretion of Giardia cysts in canines together with hygienic measures to control, like disinfection with quaternary ammonium of patients and their environment. Further studies that include more animals and multiple fecal exams on consecutive days would be necessary to confirm its efficacy in dogs.
PENGEMBANGAN METODE PENYULUHAN MENINGKATKAN PEMAKAIAN ALAT KONTRASEPSI
Authors: Majid Makhrajani
Published: November 2019

Program KB ke depan akan difokuskan, salah satunya pada peningkatan pemakaian alat kontrasepsi, pendewasaan usia pekawinan, menjarangkan kehamilan, pengaturan jumlah anak dan masih banyak lagi sasaran lain yang ingin ditingkatkan. Penelitian ini bertujuan mengetahui perubahan pengetahuan dan sikap masyarakat sebelum dan setelah dilakukan penyuluhan terhadap pengaturan jarak kehamilan, jumlah anak dan tingkatkesejahteraan keluarga selama pemakaian alat kontrasepsi. Desain penelitian yang digunakan adalah kuasi eksperimen dengan desain one group pretest-postest. Objek penelitian adalah ibu-ibu yang pernah menggunakan alat kontrasepsi di Kota Parepare. Jumlah responden sebanyak 117 orang. Teknik yang digunakan adalah accidental sampling. Teknik pengumpulan data dengan menggunakan kuesioner yang diberikan kepada responden sebelum dan sesudah penyuluhan. Analisis data dengan menggunakan uji t pada variabel independen. Hasil penelitian ini adalah ada perubahan tingkat pengetahuan dan sikap masyarakat sebelum dan sesudah dilakukan penyuluhan tentang jarak kehamilan, pengaturan jumlah anak dan tingkat kesejahteraan keluarga terhadap peningkatan pemakaian alat kontrasepsi di Kota Parepare.
FAKTOR RISIKO KEJADIAN PRE-EKLAMSIA PADA IBU HAMIL DI KABUPATEN BELU
Authors: Bere Paulina Ika D.R , Sinaga Mindo , Fernandez H.A
Published: November 2019

Pre-eklamsia merupakan suatu keadaan patologi yang ditandai dengan adanya hipertensi, proteinuria dan edema. Penelitian ini bertujuan untuk menganalisis faktor risiko dengan kejadian pre-eklamsia pada ibu hamil di Kabupaten Belu. Jenis penelitian yang digunakan adalah penelitian retrospektif dengan desain case control dan menggunakan pendekatan kuantitatif dan kualitatif. Penelitian ini dilaksanakan pada wilayah kerjaPuskesmas di Kabupaten Belu, periode Januari–Maret 2015. Analisis statistik yang digunakan adalah chi-square dan Odd Ratio. Besar sampel kasus 40 ibu dan kontrol 40 ibu yang diambil dengan teknik purposivesampling. Hasil penelitian ini ditemukan adanya hubungan yang signifikan antara faktor risiko umur (p=0,007;OR=0,286;95%CI=0,133-0,721), paritas (p=0,014;OR-0,323;95%CI=0,130-0,804), riwayat hipertensi(p=0,007;OR=3,462;95% CI=1,379-8,691), riwayat pre-eklamsia (p=0,000;OR=2,379;95% CI=1,803-3,139), antenatal care (p=0,000;OR=0,140;95%CI=0,052-0,378) terhadap kejadian preeklamsia. Variabel yang mempunyai risiko terjadinya pre-eklamsia adalah riwayat hipertensi mempunyai risiko 3 kali, riwayat pre-eklamsiamempunyai risiko 2 kali sedangkan variabel umur, paritas dan pemeriksaan kehamilan (ANC) merupakan faktor protektif.
HUBUNGAN PENDIDIKAN, PEKERJAAN DAN SIKAP IBU MENYUSUI TERHADAP PRAKTIK MENYUSUI BAYI USIA 0-6 BULAN DI WILAYAH KERJA UPK PUSKESMAS TELAGA BIRU SIANTAN HULU PONTIANAK UTARA
Authors: Trianita Winda , Nopriantini Nopriantini
Published: November 2019

In the practice of nursing one factor that plays an important role in the success of breastfeeding is feeding techniques. When the breastfeeding technique is incorrect, it can cause a variety of problems. No maximum breastfeeding will result in less good, because the baby’s sucking is very influential on subsequent milk production stimulation. Based on data obtained from UPK Siantan Hulu Health Center Blue Lake District of  North Pontianak, the prevalence of exclusive breastfeeding in 2014 is still low, as much as 61.88% with a target of 80%. This study aims to determine the relationship of education, employment and attitude towards the practice of breastfeeding mothers of infants aged 0-6 months in the working area of   Puskesmas UPK Siantan Upper Blue Lake District of North Pontianak. This type of research is analytic survey with cross sectional approach. Sampling was done by purposive sampling with a sample of 59 people. Data were analyzed by chi square test. The results showed no association between maternal education with the practice of breastfeeding. There is a relationship between the work and the attitude towards the practice of breast-feeding mothers. Suggested to the local health authorities to continue to provide information on the practice of breastfeeding in the right way, through the distribution of posters, leaflets and other education media, and routinely perform counseling and individual and group counseling at health centers or at Posyandu activities.
FAKTOR-FAKTOR YANG MEMPENGARUHI IBU DALAM PEMBERIAN ASI EKSKLUSIF KEPADA BAYI DI PUSKESMAS SEBANGKAU KECAMATAN PEMANGKAT KABUPATEN SAMBAS
Authors: Fricilia Rodhiya , Agustiansyah Agustiansyah
Published: November 2019

Exclusive breastfeeding is only breastfeeding without additional food and drinks in infants aged 0-6 months. Even water is not given in this exclusive breastfeeding stage. Breast milk is a fat emulsion in a solution of protein, lactose, and organic salt secreted by the two halves of the mother’s breast gland, as the main food for the baby. The composition of breast milk is not the same from time to time, this is based on lactation stage (Setiowati, 2010). This study aims to determine the relationship between knowledge, attitudes, maternal work and promotional media for formula milk with exclusive breastfeeding at the Puskesmas in the District of Pemangkat, Sambas Regency. The type of research used is the survey method with a cross sectional study approach. Sampling was done by purposive sampling with a sample of 57 mothers. Data analysis was performed using the chi-square test. The results showed that there was no relationship between the knowledge of mothers with exclusive breastfeeding (p = 0.054), there was no relationship between the attitudes of mothers with exclusive breastfeeding (p = 0.933), there was no correlation between the work of mothers with exclusive breastfeeding (p = 0.962) , and there is no relationship between the promotion media of formula milk with exclusive breastfeeding (p = 0.985). It was concluded that of all the variables tested there was no relationship with exclusive breastfeeding in infants in the Puskesmas that was as far as Pemangkat District, Sambas Regency. It is recommended that mothers give exclusive breastfeeding to their babies until they are 6 months old.