bluuebunny/crossref_metadata_2025 huggingface dataset:
The Implementation of iSpring Quiz Maker as The Online Exam Tool of Physics Worklab during the Covid-19 Pandemic
Authors: Gideon Samuel , Sitinjak Anna Angela , Darmadi Herry , Rafli Muhammad
Published: July 2022

One of the implementation of advances in information and communication technology that can be used for online exam is the iSpring Quiz Maker. This research aims to: (1) determine the feasibility of iSpring Quiz Maker as the online exam tool of physics worklab; (2) determine the student interest responses in using iSpring Quiz Maker as the online exam tool of physics worklab; as well as (3) determine the effectiveness of iSpring Quiz Maker as the online exam tool of physics worklab. The method of this research is research and development (R & D) by applying the ADDIE (analysis stage, design stage, development stage, implementation stage and evaluation stage) model. The results showed that: (1) iSpring Quiz Maker is very feasible as physics worklab online exam tool based on the assessment of both material and media expert validators; (2) Students are very interested in using iSpring Quiz Maker as physics worklab online exam tool; and (3) iSpring Quiz Maker has not been effective as physics worklab online exam tool because the percentage of the total students who got score of 50 is 77.6% while the percentage of the total students who got score > 50 is 22.4%.
Kedudukan Sertifikat Sebagai Alat Bukti Yang Kuat Menurut Hukum Positif dan Hukum Islam
Authors: Melynia Shely , Fathimah Ema , Gibtiah Gibtiah
Published: July 2022

Abstract: This article aims to understand the position of certificates as legal evidence according to Law Number 5 of 1960 article 19 paragraph (2) letter c and Islamic law. The method used by the author in this article is a normative legal research method. The approach method used is a comparative approach. The data used is secondary data consisting of primary legal materials, secondary legal materials and tertiary legal materials. The results of the study show that the certificate in the view of Islamic Law is proof and a strong certainty for the certificate holder itself. Meanwhile, according to Law Number 5 of 1960 Article 19 paragraph (2) letter c, certificates are very strong for proof before a court as long as there is no evidence to prove that the certificate is not true or false, both from physical data and juridical data. The similarity of the two laws is that the certificate must be issued from the local land office and known or signed by the official who made the deed or land certificate. And also in the certificate must include physical data and juridical data to obtain certainty and be recognized by the court as long as there is no evidence to the contrary.
Sharia Economic Dispute Settlement Between Religious Courts And Basyarnas
Authors: Oslami Achmad Fikri
Published: July 2022

This study aims to examine the settlement of sharia economic disputes that arise in the event of a dispute between the two parties. This study will answer the formulation of the problem, namely: Why can the settlement of sharia economic disputes be resolved through the Basyarnas and the Religious Courts? the impact of resolving sharia economic disputes through Basyarnas and the Religious Courts; Basyarnas status after the enactment of Law Number 50 of 2009 concerning the Second Amendment to Law Number 7 of 1989. In this study, the authors used literature research, then analyzed it using content analysis methods related to the problems studied. The research method used is a normative juridical research method. The results of this study state that the birth of Law Number 03 of 2006 which has been updated with Law Number 50 of 2009 has brought major changes to the existence of the current Religious Courts, one of the fundamental changes is that the Religious Courts have the authority to examine, hear, and resolve sharia economic disputes through litigation. The settlement of sharia economic disputes as regulated in Law Number 30 of 1999 has been carried out by Basyarnas and is still used as a non-litigation institution authorized to resolve disputes.
Istihsan Concept in Multi Contract Online Transactions of Go-Food Services in The Go-Jek Application
Authors: Lusiana Lusiana , Harun Muhammad , Fauziah Fauziah , Abdillah Muhammad
Published: July 2022

Technological developments are very influential on the lives of the world's people, one of which is used for business purposes or known as Electronic Commerce (E-Commerce). Several E-Commerce facilities such as online transportation, online payments, online shopping, are practical facilities that are in great demand by the public. As an online food delivery service known as Go-Food. Go-Food application transactions or food orders have several contracts (multi-contract). This research is a field research. The data collected is analyzed descriptively qualitatively, that is, describes as clearly as possible the related data, then concluded deductively, that is, draws conclusions from statements that are general to specific. So that understanding the research results can be easily understood and understood. Some of the contracts in Go-Food transactions are as follows: PT. Go-Jek and merchants. PT. Go-Jek with merchants is an ijarah agreement. Transactions between Pt. Go-Jek and Driver, a collaboration between Go-Jek and drivers and known as the cooperation system (Syirkah). Contract between the consumer and the driver, if the consumer makes a payment using his own go-pay system, the transaction that occurs between the two is buying and selling, but if it is in cash, then there is a wakalah contract, here it will also be a qardh contract because the consumer owes it to the driver. Contracts between drivers and merchants, there are buying and selling activities between drivers and merchants, buying and selling represented by the driver to the merchant, representative transactions like this in Islamic law are known as wakalah contracts. With the istihsan method, economic activities that provide convenience and good benefits without harm and injustice to mankind can be answered and proven by the istihsan method, so that sharia economic activities can always exist and can compete with conventional economics.
The Differences of Men's and Women's Shares in Islamic Inheritance Law Defense to Criticism and Blasphemy
Authors: Bachri Syabbul
Published: July 2022

This study aims to provide an explanation of the defense against criticism and blasphemy for the differences in the male and female divisions and their arguments. This research is a normative study with a conceptual approach. The primary and secondary data collected were then analyzed using a content analysis approach to provide an overview of the defense and arguments for the application of male and female share differences in Islamic inheritance law. The results of the study show that criticism and blasphemy from those who reject the difference in inheritance distribution between men and women cannot be justified because not in all cases do women get a smaller share than men. There are many cases where women get the same and even bigger share than men. Moreover, justice also cannot be interpreted as equal distribution, considering that in scientific terms, the term distributive justice is also known. The interpreters argue that the provisions of section 2:1 between men and women are a decree from Allah that must be carried out by arguing that the statements in the verses of the Qur'an are clear and qath'i. The demand for new ijtihad cannot be justified considering that in ushul fiqh there are rules which state that there should be no ijtihad in the provisions of qath'i texts.
Upper Bashkirian deposits in the Sharyu River basin (the Chernyshev Ridge): lithology, carbon and oxygen isotopes, conditions of sedimentation
Authors:   Institute of Geology FRC Komi SC UB RAS, Sandula A.N. , Shmeleva L.A.
Published: July 2022

The Upper Bashkirian deposits in the Srednievorota section (the Sharyu River, the Chernyshev Ridge) are composed of un¬changed limestones. In their composition δ13CPDB = 0.3...3.9‰, δ18ОSMOW = 19.0...24.3‰. Isotopic ratios depend on changes of sedimentation conditions during Late Bashkirian. Formation of studied deposits took place in two stages. At the first stage, during the period of maximum regres¬sion and activation of tectonic mode, rock associations of microbial-pelitomorphic and bioclastic limestones were formed. δ13C gradually increases from 1,4 to 3,1‰, and then decreases to 1,2‰, and δ18О is first equal to 22,3...23,2‰, and then decreases to 20,9‰. At the second stage rock associations of algal, microbial-bioclastic and bioclastic limestones with crinoids and corals were formed on a shallow carbonate shelf during the gradual deepening of the sea. In the isotopic system, there is a gradual increase of average values of δ13C from 2,75 to 3,69‰, and average values of δ18O are equal to 22,18...22,88‰ with deviations of 2–3‰.
Multisectional vibration pump as an element of the hydraulic system that affects the rheological properties of the extracted product
Authors:   Industrial University of Tyumen, Gadzhiev M.D. , Strekalov A.V.
Published: July 2022

Downhole production of hydrocarbons is a complex techno¬logical process. The choice of a mechanized method of oil production in various operating conditions is the basis for their subsequent effective work, the result of which should be economic feasibility. The operation of wells by traditional methods of production in complicated (hard thermo-baric) conditions is accompanied by many problems that lead to a reduction in the service life of downhole pumping equipment. The use of alternative (new) methods of oil production would solve such problems. An alternative extraction method is a vibratory pump. In previous works, the installation of a vibration pump (vol¬umetric and dynamic) was considered, which consists of series-connected sections. The same article presents a characteristic of a hydraulic system, which can be described as a non-linear equation, through a nodal analysis of the “reservoir-well-pump-mouth” structure. The influence of the vibration effect of the pump and the formation of receipt processes on the viscosity of the liquid is considered. It is concluded that the presented pump can lead to the trans¬formation of the structural and rheological properties of the liquid, reducing its viscosity.
A dor silenciosa do corpo: análise dos casos de violência autoprovocadas no Brasil
Authors:   Universidade Federal de Pernambuco, Vitória de Santo Antão, Arruda Laís Eduarda Silva de , Silva Luís Roberto da ,   Universidade Federal de Pernambuco, Vitória de Santo Antão, Santos Isadora Sabrina Ferreira dos ,   Universidade Federal de Pernambuco, Vitória de Santo Antão, Silva José Thiago de Lima ,   Universidade Federal de Pernambuco, Vitória de Santo Antão, Silva Ricardo José da ,   Instituto Federal de Educação, Ciência e Tecnologia da Paraíba, Oliveira Emília Carolle Azevedo de ,   Instituto Aggeu Magalhães/Fundação Oswaldo Cruz
Published: July 2022

Contexto: As violências autoprovocadas são caracterizadas por duas formas de autoagressão a suicida e a não suicida, com a busca do indivíduo pelas formas de agressão a si mesmo, sendo um comportamento intencional e agressivo à sua saúde. Objetivo: Analisar os dados de violências autoprovocadas nas regiões brasileiras, no período de 2009-2017 e discutir sobre esse problema no âmbito da saúde pública. Metodologia: Estudo epidemiológico transversal, descritivo, de abordagem quantitativa com as notificações do Sistema de Informação de Agravos e Notificações sobre violências autoprovocadas. Utilizaram-se o Software R e o Microsoft Excel para as análises estatísticas. Resultados: No Brasil a prevalência dos casos de violências autoprovocadas foi de 14,20/100 mil hab. (2009-2017) com a maior prevalência na região Sul, no sexo feminino, na faixa etária de 20-29 anos, com baixa escolaridade e raça/cor parda. A maioria dos casos ocorreram por envenenamento e na residência. Conclusão: O estudo identificou um cenário alarmante dos casos de violências autoprovocadas, principalmente, quando considerada as prevalências nas regiões Sul e Sudeste do Brasil, no público adulto jovem, população economicamente ativa. Tais achados servem para direcionar e subsidiar o planejamento de estratégias preventivas eficazes para a não realização do suicídio; podendo abranger desde a incorporação de ações como a restrição da comercialização de armas, a execução de campanhas de conscientização da população para identificar quais os fatores de risco associados com o comportamento não suicida e suicida e o auxílio aos indivíduos em situação de risco.
Gestão em enfermagem em contexto de psiquiatria: gestão do tempo no exercício das competências dos gestores
Authors:   Hospital Magalhães Lemos, Porto, Portugal, Alferes Luisa Pires , Martins Maria Manuela ,   Escola Superior de Enfermagem do Porto/Instituto de Ciências Biomédicas Abel Salazar, Santos Margarida Reis ,   Escola Superior de Enfermagem do Porto/Instituto de Ciências Biomédicas Abel Salazar, Poeira Ana ,   Escola Superior de Saúde do Instituto Politécnico de Setúbal, Alferes Rui ,   Hospital Magalhães Lemos, Porto, Portugal, Pires Regina ,   Escola Superior de Enfermagem do Porto/Instituto de Ciências Biomédicas Abel Salazar
Published: July 2022

Contexto: Gerir recursos humanos, atividades e processos administrativos, são desafios diários que se pretendem traduzir na qualidade assistencial aos utentes. As mudanças no paradigma de gestão nas unidades de saúde em Portugal determinam que os enfermeiros gestores de saúde mental e psiquiatria contribuam para a qualidade e produtividade dos serviços, o que torna imprescindível uma boa gestão do tempo. Objetivo: Compreender a distribuição do tempo pelas atividades dos cinco domínios de competências do enfermeiro gestor atendendo às suas características pessoais e aos contextos clínicos de saúde mental e psiquiatria. Metodologia: Estudo quantitativo, descritivo e transversal, realizado em unidades de saúde de assistência psiquiátrica portuguesas. Amostra não probabilística, intencional, de 48 enfermeiros gestores. Dados colhidos com questionário online e analisados com recurso a estatística descritiva e analítica. Resultados: O valor médio do tempo despendido na realização das atividades inerentes às competências Prática Profissional, Ética e Legal, Gestão de Cuidados e Gestão de Recursos Humanos situa-se acima de dois terços do total do score máximo. Nas competências Intervenção Política e Assessoria e Desenvolvimento Profissional situa-se em valores de média próximos de metade, ou seja, as que os gestores consideraram despender menos tempo. Gestão de Cuidados é a competência que, em média, os gestores consideraram despender mais tempo na concretização das atividades que a integram. Conclusão: Conclui-se uma assimetria na distribuição do tempo atribuído à execução das tarefas inerentes a cada uma das competências do gestor de enfermagem, nomeadamente na Prática Profissional Ética e Legal, Gestão de Recursos Humanos e Gestão de Cuidados.
Saúde física e mental de profissionais de unidades de saúde da família na pandemia do COVID-19
Authors:   Hospital das Clínicas de Pernambuco. Brasil., Santos Washington José dos , Silva Edylla Thales Araújo Ferreira da ,   Residência Multiprofissional em Saúde da Família da Secretaria de Saúde do Recife, Altino Juliane Araújo ,   Residência Multiprofissional em Saúde da Família da Secretaria de Saúde do Recife, Vieira Carlos Bento Leão ,   Residência Multiprofissional em Saúde da Família da Secretaria de Saúde do Recife, Meira Mateus do Amaral ,   Prefeitura da Cidade do Recife., Monte Conciana Duarte ,   Hospital das Clínicas de Pernambuco. Brasil.
Published: July 2022

Contexto: A pandemia do novo coronavírus mudou substancialmente a rotina diária de trabalho e sensação de segurança da população, e nos profissionais de saúde isto pode gerar sintomas de depressão, ansiedade, insônia e angústia. Objetivo: A pesquisa teve como objetivo avaliar a possível relação entre a saúde física de profissionais de saúde da atenção primária e a prevalência de transtornos mentais comuns(TMC) em duas unidades de saúde da família de Recife, no estado de Pernambuco-Brasil. Método: Trata-se de um desenho transversal analítico, utilizou um questionário sobre saúde física e o questionário Self Report Questionnaire 20 (SRQ-20). Resultados: Um total de 67 participantes responderam o questionário, sendo 87,3%(n=55) do gênero feminino, com média de idade 42,53(DP=10,12). A pandemia do novo coronavírus afetou a saúde física negativamente em 35,8%(n=24) dos participantes, e 64,2%(n=43) relataram não terem sofrido alteração. Em relação a TMC foi encontrado em 46,3%(n=31) das pessoas que responderam ao questionário. Foi significativa a razão de prevalência entre indivíduos que fazem atividade física e TCM 0,47(IC=0,27-0,83). Conclusão: Os resultados demonstram a necessidade do desenvolvimento de ações e estratégias que minimizem os efeitos da pandemia sobre as saúdes física e mental dos trabalhadores da atenção básica. Se houver secções dentro do resumo devem estar a negrito e iniciar-se numa nova linha
DEEP LEARNING DETECTION OF FACIAL BIOMETRIC PRESENTATION ATTACK
Authors:   Department of Computer and Communication Systems Engineering, Faculty of Engineering, University Putra Malaysia (UPM), Malaysia, Shibel Ahmed Muthanna , Ahmad Sharifah Mumtazah Syed ,   Department of Computer and Communication Systems Engineering, Faculty of Engineering, University Putra Malaysia (UPM), Malaysia, Musa Luqman Hakim ,   Department of Computer and Communication Systems Engineering, Faculty of Engineering, University Putra Malaysia (UPM), Malaysia, Yahya Mohammed Nawfal ,   Department of Computer and Communication Systems Engineering, Faculty of Engineering, University Putra Malaysia (UPM), Malaysia
Published: July 2022

Face recognition systems have gained increasing importance in today’s society, which applications range from access controls to secure systems to electronic devices such as mobile phones and laptops. However, the security of face recognition systems is currently being threatened by the emergence of spoofing attacks that happens when someone tries to unauthorizedly bypass the biometric system by presenting a photo, 3-dimensional mask, or replay video of a legit user. The video attacks are perhaps one of the most frequent, cheapest, and simplest spoofing techniques to cheat face recognition systems. This research paper focuses on face liveness detection in video attacks, intending to determine if the provided input biometric samples came from a live face or spoof attack by extracting frames from the videos and classifying them by using the Resnet-50 deep learning algorithm. The majority voting mechanism is used as a decision fusion to derive a final verdict. The experiment was conducted on the spoof videos of the Replay-attack dataset. The results demonstrated that the optimal number of frames for video liveness detection is 3 with an accuracy of 96.93 %. This result is encouraging since the low number of frames requires minimal time for processing.
A reformulação em uma perspectiva interacionista para o estudo das relações de discurso
Authors: Cunha Gustavo Ximenes
Published: July 2022

Neste trabalho, buscamos compreender, a partir da perspectiva interacionista da Equipe Interaction & Formation, o papel das relações de discurso, mas, em particular, da reformulação, no domínio da formação profissional inicial. Para isso, apresentamos inicialmente uma abordagem para o estudo das relações de discurso que seja compatível com a proposta interacionista da equipe, bem como a maneira como a reformulação pode ser compreendida no âmbito dessa abordagem. Em seguida, apresentamos considerações sobre o corpus analisado neste estudo, que se constitui de duas sequências de interações ocorridas em 2005, no cantão de Genebra, Suíça, nas quais a mesma expressão conectiva reformulativa do francês (“en fait”) é empregada pelos aprendizes que participam de cada sequência. Por fim, procedemos à análise comparativa das sequências, para mostrar como um mesmo recurso linguístico, a relação de reformulação sinalizada pela expressão conectiva “en fait”, auxilia os participantes da interação a construir contextos distintos, mais ou menos favoráveis à formação profissional.
ANALYSIS OF ACTUAL, TYPICAL AND NORMATIVE CLIMATE DATA IN THE CONTEXT OF BUILDINGS ENERGY MODELING
Authors: Sukhodub І.О. , Shklyar V.I. , Dubrovska V.V.
Published: July 2022

This article analyses the actual, normative monthly and typical detailed climatic data for the city of Kyiv. Data on actual outdoor air temperatures during 2014-2021 were compared with indicators in accordance with Ukrainian regulations and the most common typical hourly climate files used for building energy modeling: International Weather for Energy Calculations (IWEC), Meteonorm, Typical Meteorological Year (TMY) from PVGIS tool and Onebuilding web-site. The values for outside air temperatures were compared on an average monthly basis and using the number of hours of outside air temperature duration. The latter approach allows to more accurately assess the energy efficiency indicators and energy consumption of heat supply systems with heat pumps. As the buildings energy need and energy consumption for heating values are significantly affected by heat gains due to solar radiation, a comparison of the normative value of global radiation on the horizontal surface with the values from the most common typical climatic data was also performed based on an average monthly basis. Taking into account the set of analysed climatic factors using monthly indicators for outside air temperatures and number of hours of outside air temperature duration, it is decided to use Meteonorm hourly data for Kyiv for further dynamic energy modeling of building with heat supply system based on different types of heat pumps, including the air-to-water and water(brine)-to-water ones. Also, climatic data used in RETScreen program show similar figures as normative values and therefore this program will be used for further technical and economic analysis as well and the results will be compared to the specialised program for heat pumps calculations GeoT*SOL, which also provides the detailed calculation of heat pumps system technical performance and economic calculations. In addition, possible deviations in the values of energy need for heating of the building when using different climatic data were estimated using the DesignBuilder / EnergyPlus software product. The potential deviation of energy need for heating results can be around -10…+6.5%.
WAVELET DE-NOISING FOR AUTONOMOUS LATITUDE DETERMINATION
Authors: Avrutov Vadym , Bouraou Nadiia , Hehelskyi Oleksii , Davydenko Serhii , Matvienko Olena , Pazdrii Olha
Published: July 2022

Autonomous determination of the latitude of the place of movable and immovable objects is used as an independent task, as well as the task of determination of the initial value of latitude for operation of both platform and platform-free navigation systems. To solve these problems, it is necessary to have an inertial measurement unit (IMU) with at least three gyroscopes and three accelerometers. When using the IMU, executed by MEMS technology, the output signals of micromechanical gyroscope and accelerometers have significant noise components. Kalman filter is usually used to filter such signals. However, for this purpose it is necessary to know, besides the exact mathematical model of sensitive elements, many of their initial random characteristics.

In the article, the research was conducted in order to investigate the use of wavelet transformation for the filtering of output signals of micromechanical accelerometers and gyroscopes for autonomous determination of the latitude of the place. The peculiarity of using wavelet transform for noisy signals is that due to changing scale, wavelets can detect differences in process characteristics on different scales, and with help of the shift we can analyze process properties at different points on the whole investigated interval. Due to the properties of this system's fullness that it is possible to restore the process by means of inverse wavelet transform. The efficiency of the developed method of increasing the accuracy of the autonomous determination of the latitude of the IMU on the basis of micromechanical gyroscope and accelerometers has been experimentally confirmed. The projections of the angular velocity of Earth rotation and gravitational acceleration were obtained from the IMU made by MEMS technology. After that, the signals of the gyroscopes and accelerometers of the inertial measuring unit were filtered, using the wavelet ‘Daubechies 10’ in decomposition, and averaged. These signals were used in a computational algorithm to determine the latitude. The results showed that, unlike the well-known Kalman filter, which almost did not increase the accuracy of the latitude calculation, wavelet denoising and further averaging reduced calculation error by almost twice.
Correlation Monitoring of Predicted and Actual Strength in CUSUM Quality Control of Concrete
Authors: Arega Tsegaye , Bhattacharjee Bishwajit
Published: July 2022

Quality monitoring (QM) with CUSUM system can result in potential economy in RMC through optimal control of target strength (by avoiding overdesign) on the one hand and through reduction of producers’ risk against rejection by the client on the other. To overcome the problems associated with the conventional 28-day compressive strength test, correlations are established between accelerated and the standard 28-day cube strength to predict the 28-day strength from the early age strength itself. This paper tried to demonstrate the lack of reliability of single correlation itself along the production time of RMC. The correlations vary with W/C as well as with type of cement. Hence it is demonstrated that correlation is concrete specific. Further, it is also demonstrated that correlation established with specimens having wide variation in the batching may result in poor correlation. Through CUSUM plots of mean and range for cube strength obtained by Monte-Carlo simulation demonstrate the utility of prediction through such correlation in QM and a methodology for monitoring the correlation itself.
HepG2-NTCP Subclones Exhibiting High Susceptibility to Hepatitis B Virus Infection
Authors: Zahoor Muhammad Atif , Kuipery Adrian , Mosa Alexander I. , Gehring Adam J. , Feld Jordan J.
Published: July 2022

HepG2 cells reconstituted with Hepatitis B virus (HBV) entry receptor sodium taurocholate co-transporting polypeptide (NTCP) are widely used as a convenient in vitro cell culture infection model for HBV replication studies. As such, it is pertinent that HBV infectivity is maintained at steady-state levels for accurate interpretation of in vitro data. However, variations in HBV infection efficiency due to imbalanced NTCP expression levels in the HepG2 cell line may affect experimental results. In this study, we performed single cell cloning of HepG2-NTCP-A3 parental cells via limiting dilution and obtained multiple subclones with increased permissiveness to HBV. Specifically, one subclone (HepG2-NTCP-A3/C2) yielded more than 4-fold higher HBV infection compared to the HepG2-NTCP-A3 parental clone. In addition, though HBV infectivity was universally reduced in the absence of polyethylene glycol (PEG), subclone C2 maintained relatively greater permissiveness under PEG-free conditions, suggesting the functional heterogeneity within parental HepG2-NTCP-A3 may be exploitable in developing a PEG-free HBV infection model. The increased viral production correlated with increased intracellular viral antigen expression as evidenced through HBcAg immunofluorescence staining. Further, these subclones were found to express different levels of NTCP, albeit with no remarkable morphology or cell growth differences. In conclusion, we isolated subclones of HepG2-NTCP-A3 which support efficient HBV production and thus provide an improved in vitro HBV infection model.
DEPs Induce Local IgE Class Switching Independent of Their Ability to Stimulate iBALT
Authors: Chudakov Dmitrii Borisovich , Konovalova Mariya Vladimirovna , Kashirina Elena Igorevna , Kotsareva Olga Dmitrievna , Shevchenko Marina Alexandrovna , Tsaregorodtseva Daria Sergeevna , Fattakhova Gulnar Vaisovna
Published: July 2022

Background. Diesel exhaust particles (DEPs) have a great impact on general increase of atopic diseases worldwide. However, it is still unknown whether DEPs induce systemic B-cell IgE class switching in secondary lymphoid organs or locally in lungs, in inducible bronchial-associated lymphoid tissue (iBALT). The aim of this work was to identify the exact site of DEPs mediated B-cell IgE class switching and pro-allergic antibodies production. Methods. We immunized BALB/c mice with different OVA doses (0.3 and 30 µg) intranasally in the presence and absence of two types of DEPs, SRM1650B and SRM2786. We used low (30 µg) and high (150 µg) DEPs doses in our study. Results. Only high DEP dose induced IgE production regardless of particle type. Local IgE class switching was stimulated upon treatment with both types of particles with both low and high antigen doses. Despite the similar ability of two standard DEP samples to stimulate IgE production, their ability to induce iBALT formation and growing, was markedly different upon co-administration together with low antigen doses. Conclusion. DEPs induced local IgE class switching takes place in pre-existing iBALTs, independently of de novo iBALT formation, at least in the case of SRM1650B co-administrated with low antigen doses.
Does Deep Learning Have Epileptic Seizures? On the Modeling of the Brain
Authors: Depannemaecker Damien , Lopez Léo , Gauld Christophe
Published: July 2022

If the development of machine learning and artificial intelligence plays a role in many fields of research and technology today, it has a special relationship with neurosciences. Indeed, historically inspired by our knowledge of the brain, deep learning shares some vocabularies with neurosciences and can sometimes be considered a brain’s model. Taking the particular example of epileptic seizure, which can develop in any biological neural tissue, we raise the question if and how the models used for deep learning can capture or model these pathological events. This particular example is a starting point to discuss the nature, limits, and functions of these models, and what we expect from a model of the brain. Finally, we argue that a pluralistic approach leading to the integrated coexistence of different models is necessary to study the brain in all its complexity.
Effect of pre-sowing magnetic treatment of seeds with bio- and mineral fertilization on the soybean cultivated in a saline calcareous soil
Authors: T. Rashad Rama , Shaban Khaled A. H. , Ashmaye Samia H. , Abd El-Kader Mona G. , Mahmoud Awatef A.
Published: July 2022

Bio-farming is an eco-friendly advance that minimizes the required chemical additives for optimizing the quality of crops that their storage is often accompanied by seeds’ components degradation. Magnetic treatment of seed was considered as a promising tool improves germination and growth. This study aims to evaluate the effect of individual and combined application of bio-fertilizers and the N-P-K mineral fertilizers preceded by magnetic treatment of dry and/or water-soaked seeds before sowing on the yield and quality of soybean cultivated in a saline soil.The field experiment was carried out in a split-split plot design with triplicates. The main two factors (F1) were not bio-fertilized and bio-fertilized plots. The sub-factors (F2) were three application rates (A: 50%, B: 75%, and C: 100%) of recommended doses of the three N, P, K fertilizers. The sub-sub factors (F3) were seeds not magnetically treated (NM) and magnetically treated (M). All factors were studied for dry soybean seeds (without soaking) and soaked seeds in magnetically treated water. After harvesting, soil and plant samples were analyzed. The most significant increase in the soybean seed yield (kg ha-1) was by 49.98% for the bio-fertilized magnetized dry seeds at 75% and 100% mineral N-P-K fertilization compared with the NM soaked seeds at 50% N-P-K (A rate) without bio-fertilization. The 75% mineral fertilization significantly increased the protein (%) by 41.69% and decreased the proline (mg g-1dw) by 46.68%. Magnetic treatment of seeds before cultivation and combined bio/mineral N-P-K fertilization reduced the Proline that alleviats the stress conditions.
MODELING OF MOBILE ROBOT WITH OBSTACLE AVOIDANCE USING FUZZY CONTROLLER
Authors: Khudaverdiyeva Mahabbat
Published: July 2022

This paper presents the modeling of a robot's navigation using ultrasonic sensors under uncertainty. The robot tries to avoid obstacles by using the fuzzy logic controller to process the data coming from three ultrasonic sensors. To assess the performance of fuzzy logic optimized robot navigation controller with ultrasonic sensors, which measure the distance by calculating the time spent on the object and its return, the obstacles are placed in front of, left, and right of the robot.  Mamdani fuzzy reasoning system is used for the designed controller for its intuitive properties and fewer setting parameters which reduces the amount of time spent on the programming of the controller. 25 rules are considered to cover a robot’s possible interactions with obstacles. For an easy understanding of navigation architecture and rapid algorithm implementation, in this paper, a MATLAB simulation framework is developed. MATLAB/Simulink is one of the best simulation tools required to design the architecture and verify algorithms with real-time constraints. Resultant models of the fuzzy optimized controller demonstrate the superior performance of the fuzzy logic controller with high adaptability to the environment while maintaining a sufficient level of accuracy. The designed fuzzy controller can be used in microprocessor/microcontroller-based robots owing to easiness in implementation and coding.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 09.07.2022 г. по 15.07.2022 г.
Authors: Гусева Валерия , Поспелов Михаил , Зимирова Анастасия , Иванова Александра , Чумачкова Елена , Дмитриева Людмила , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир
Published: July 2022

В обзоре представлен анализ эпидемиологической ситуации в странах мира по

COVID-19, за неделю с 09.07.2022 г. по 15.07.2022 г.
Characterizing the limits of shallow shotgun metagenomics for taxonomic profiling of human gut microbiota in clinical studies
Authors: Goutorbe Benoit , Abraham Anne-Laure , Mariadassou Mahendra , Plauzolles Anne , Bidaut Ghislain , Halfon Philippe , Schbath Sophie
Published: July 2022

Background Shallow shotgun metagenomics (SSM) has been recently suggested as a promising strategy to study human microbiota, providing nearly identical taxonomic profiles to deep shotgun metagenomics but at a sequencing cost as low as that of metabarcoding. To help clinical researchers determine whether shallow sequencing is appropriate for their projects, it is crucial to ascertain the accuracy of the information it provides, compared to deep sequencing. Here, we design a mapping-based workflow to build taxonomic profiles from SSM data and assess its accuracy at varying sequencing depths at both sample and cohort levels using extensive simulations and several public data sets. Results To identify genuinely present species and spuriously identified ones, we propose a novel data-driven filtering method based on machine learning techniques that largely outperforms basic filtering strategies based on pre defined thresholds, resulting in reliable taxonomic profiles at different sequencing depths, ranging from 50K to 10M reads/samples. Up to 90% of species with relative abundances higher than 4.10−4 were recovered correctly at 500K reads/sample showing that only information about rare taxa is lost at shallow depths. Furthermore, our results clearly show that SSM is able to correctly recover relevant biological signal from the confidently identified taxa, such as differences between groups of patients and diagnosis-like classification. Conclusions This study confirms that SSM is suitable for clinical research on human gut microbiota. We recommend that researchers should consider moving from 16S to SSM to limit biases in taxonomic profiles, or moving from deep to shallow sequencing, when functional analyses are not the main focus, to reduce costs and be able to include more patients in research projects.
Spatial Associations of Long-term Exposure to Diesel Particulate Matter with Seasonal and Annual Mortality Due to COVID-19 in the Contiguous United States
Authors: Mathieu Martine , Gray Joshua , Richmond-Bryant Jennifer
Published: July 2022

Background
People with certain underlying respiratory and cardiovascular conditions might be at an increased risk for severe illness from COVID-19. Diesel Particulate Matter (DPM) exposure may affect the pulmonary and cardiovascular systems. The study aims to assess if DPM was spatially associated with COVID-19 mortality across three waves of the disease and throughout 2020.
Methods
We tested an ordinary least square (OLS) model, then two global models, spatial lag model (SLM) and spatial error model (SEM), designed to explore spatial dependence, and a geographically weighted regression (GWR) model designed to explore local associations.
Results
The GWR model found that associations between COVID-19 deaths and DPM concentrations may increase up to 57, 36, 43, and 58 deaths per 100,000 people in some US counties for every 1 µg/m3 increase in DPM concentration. Relative significant positive association are observed in New York, New Jersey, eastern Pennsylvania, and western Connecticut for the wave from January to May, and in southern Florida and southern Texas for June to September. The period from October to December exhibit a negative association in most parts of the US, which seems to have influenced the year-long relationship due to the large number of deaths during that wave of the disease.
Conclusions
Our models provided a picture in which long-term DPM exposure may have influenced COVID-19 mortality during the early stages of the disease, but that influence appears to have waned over time as transmission patterns evolved.
Impact of preoperative intervention in laparoscopic sleeve gastrectomy
Authors: Kashihara Hideya , Shimada Mitsuo , Yoshikawa Kozo , Tokunaga Takuya , Nakao Toshihiro , Nishi Masaaki , Takasu Chie , Wada Yuma , Yoshimoto Toshiaki
Published: July 2022

Background: This study aimed to investigate the impacts of calorie restriction and exercise as preoperative interventions in laparoscopic sleeve gastrectomy.Methods: Sixteen patients with obesity who underwent laparoscopic sleeve gastrectomy were enrolled, comprising 4 men and 12 women aged 33–62 years (mean age, 44.8 years). Their mean body weight and body mass index were 124.7 kg and 46.5 kg/m2, respectively. These patients underwent calorie restriction and exercise for a mean duration of 5.9 months before the surgery. The effect of this preoperative intervention on the postoperative outcome was then evaluated.Results: The patients achieved a weight loss of 8.3% (10.8 kg). The visceral fat area significantly decreased by 5.5%, whereas the skeletal muscle mass remained unaffected. Furthermore, the good-responder group (preoperative weight loss > 8%) showed a significantly higher percentage total weight loss (%TWL) at 1 year postoperatively than the poor-responder group (preoperative weight loss < 8%). In the multivariate analysis, preoperative weight loss of >8% revealed the independent factor of correlating 25% ≤ %TWL at 1 year postoperatively.Conclusions: Preoperative intervention with calorie restriction and exercise is effective for postoperative weight loss in laparoscopic sleeve gastrectomy.
Sex differences in placental markers and later autistic traits
Authors: Tiemeier Henning , Tsompanidis Alex , Blanken Laura , Broere-Brown Zoe , Rijn Bas van , Baron-Cohen Simon
Published: July 2022

Autism and related neurodevelopmental traits are more prevalent in males. Placental complications are also more frequent in male pregnancies. It is unclear if sex differences in placental function can predict sex differences in autistic traits. To assess this, concentrations of angiogenesis-related markers, placental growth factor (PlGF) and soluble fms-like tyrosine kinase (sFlt-1) were assessed in maternal plasma of expectant women in the late 1st (mean = 13.5[SD = 2.0] weeks gestation) and 2nd trimesters (mean = 20.6[SD = 1.2] weeks gestation), as part of the Generation R Study, Rotterdam, the Netherlands. Subsequent assessment of autistic traits in the offspring at age 6 was performed with the 18-item version of the Social Responsiveness Scale (SRS). Associations of placental protein concentrations with autistic traits were tested in sex-stratified and cohort-wide regression models, controlling for various confounders including placental weight. Mediation analysis was conducted to study if placental proteins mediated the effects of biological sex on autistic traits in childhood. sFlt-1 levels were significantly lower in males in both time-points but showed no association with autistic traits. PlGF was significantly lower in male pregnancies in the 1st trimester, and significantly higher in the 2nd trimester, thus levels increased faster in males during gestation. Higher PlGF levels in the 2nd trimester and the rate of PlGF increase were associated with higher autistic traits in linear regression models (PlGF-2nd : n = 3469,b = 0.24[SE = 0.11], p = 0.03). In sex-stratified analyses, these associations were significant in females but not males. Mediation analyses showed that higher autistic traits in males were partly explained by higher PlGF or a faster rate of PlGF increase in the second trimester (PlGF-2nd : n = 3469, ACME: b = 0.006, [SE = 0.002], p = 0.004). In conclusion, placental sex differences in PlGF levels are linked to sex differences in autistic traits.
Development and Validation of the Thirst Distress Scale for Patients with Autosomal Dominant Polycystic Kidney Disease
Authors: Ozcan Seyda Gul , Bek Sibel Gokcay , Eren Necmi , Atli Zeynep , Yildiz Abdülmecit , Kocyigit İsmail , Cavdar Caner , Tunc Sertac , Waldréus Nana , Ecder Tevfik , Seyahi Nurhan
Published: July 2022

Background and Aims:
Thirst, is the main driver for fluid consumption. Abundant water intake is advised for patients with autosomal dominant polycystic kidney disease (ADPKD). However, daily routines may limit water intake. There is no established tool to quantify the drivers of water intake in ADPKD patients. The aim of this study was to modify and validate a thirst distress scale (TDS) to identify the factors that influence water intake in ADPKD patients.
Methods
The TDS-heart failure questionnaire was first modified to TDS-PKD to adapt to patients with ADPKD to assess (a) the intensity of thirst, (b) the consequences if the quench for thirst is not satisfied enough and (c) the disturbing effects of thirst on quality of life. Then, the TDS-PKD questionnaire was translated to Turkish using the guidelines of the World Health Organization. An electronic survey with the SurveyMonkey platform was used to collect data. Thirst intensity was evaluated using a visual analog scale (VAS).
Results
The questionnaire was filled in by 186 ADPKD patients, of which 126 were on tolvaptan therapy. The TDS-PKD questionnaire showed good internal consistency, with a Cronbach's alpha value of 0.859. According to the exploratory factor analysis, a three-factor structure was obtained. Three factors explained 60.7% of the total variance. There was a positive and statistically significant correlation between the total TDS and VAS scores (r = 0.589, p < 0.001). The average TDS-PDK score was 39.0 ± 1.4.
Conclusion
The TDS-PKD questionnaire is a valid and reliable tool for evaluating the thirst distress in ADPKD patients.
Dapagliflozin alleviates diabetic kidney disease via HIF‐1α/HO1 mediated ferroptosis
Authors: Wang yihui , Chang Dongyuan , Zhao Ming-hui , Chen Min
Published: July 2022

Background: Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease. In recent clinical trials, sodium-glucose cotransporter 2 inhibitors (SGLT2i) showed excellent renoprotection effects, but the underlying mechanism remains to be investigated. Previous studies have revealed an important role of ferroptosis, which is mediated by iron overload and lipid peroxidation, in the progression of DKD. Therefore, it is of interest to explore the effects of SGLT2i on ferroptosis in DKD due to its role in alleviating oxidative stress.Methods: Diabetic (db/db) mice were administered with dapagliflozin or solvent treatment from 9 to 22 weeks of age, and were compared with non-diabetic (m/m) mice. High glucose/high fat (HG/HF) was applied to HK-2 cells, and effects of dapagliflozin on ferroptosis in HK-2 cells as well as the underlying mechanism were investigated.Results: Typical changes of ferroptosis including massive lipid peroxidation, reduced antioxidant capability, and iron overload were found in db/db mice and HG/HF treated HK-2 cells. Furthermore, increased expression of hypoxia‐inducible factor‐1α (HIF‐1α) and heme oxygenase-1 (HO1) was observed in db/db mice and HG/HF cultured cells as well. Dapagliflozin treatment significantly ameliorated the ferroptosis-related changes via inhibiting HIF‐1α/HO1 axis in vivo and in vitro. Besides, downregulation of HIF‐1α/HO1 axis rescued ferroptosis, while overexpression of HO1 aggravated ferroptosis induced by HG/HF in HK-2 cells. In DKD patients, the expression level of GPX4 in the kidney was significantly lower than that in healthy controls.Conclusion: SGLT2i play a renal protective effect, at least in parts, via inhibiting HIF‐1α/HO1 axis mediated ferroptosis.
Clustering of Juvenile Canavan disease in an Indian community due to population bottleneck and isolation: Genomic signatures of a founder event
Authors: Arunachal Gautham , Kotambail Ananthapadmanabha , Selvam Pavalan , Muthusamy Karthik , Thomas Maya , Sudhakar Sniya , Ghati Chetan , Danda Sumita
Published: July 2022

Mild/juvenile Canavan disease (M/JCD) is less frequently reported in literature and little is known about its pathogenetic mechanisms. We report a comprehensive investigation into the pathogenetic mechanism of a novel ASPA(NM_000049.4):c.526G > A(p.Gly176Ser) variant in two families. The families belong to Telugu Devanga Chettiar community (TDC) from southern India. TDC has a complex history of migration from their historical origin centuries ago with high endogamy. TDC probably has the highest clustering M/JCD recorded historically (around 24 cases). The pathogenic variant was shown to cause non-classical splicing defect resulting in two different transcripts. The splicing aberration, a loss of function mechanism coupled with a milder missense effect can explain the milder phenotype compared to the infantile onset CD. The high clustering of an extremely rare form of neurodegenerative disorder with reduced fitness, indicated to a possibility of founder event. Genotyping array of TDC and multiple distinct populations of Indian origin for several population genetic parameters was performed. It yielded robust signatures of a founder event, such as a high fixation index, increased runs of homozygosity and identity-by-descent estimation in TDC in the absence of consanguinity; large haplotype with high linkage disequilibrium comprising the pathogenic variant; presence of a robust population structure; mutation dating, estimating the age of the potential founder of TDC at around 375 years; possibly a high carrier rate in TDC. This study has not only focused its attention on natural history and pathogenetics but also paves way for carrier screening programs in TDC and future therapeutic studies.