bluuebunny/crossref_metadata_2025 huggingface dataset:
PRIMEIRA DESCRIÇÃO DA MUTAÇÃO HBB:C.291_294INSGCAC EM HOMOZIGOSE ASSOCIADA AO FENÓTIPO DE TALASSEMIA BETA MAIOR EM UMA FAMÍLIA BRASILEIRA
Authors: Santos MNN , Pedroso GA , Oliveira BB , Carvalho LEM , Albuquerque DM , Jorge SEDC , Costa FF , Sonati MF
Published: October 2024

Objetivo: As mutações comumente observadas na talassemia β envolvem substituições de nucleotídeo único ou inserções/deleções de poucos nucleotídeos, afetando a expressão do gene β por meio de vários mecanismos que podem resultar em redução parcial (β+) ou ausência (β0) da síntese da cadeia β. Método: Descrevemos a análise molecular do gene β em dois irmãos (um menino de 3 anos e uma menina de 10 anos) com quadro de anemia grave e dependentes de transfusão sanguínea, encaminhados pelo HEMOCE; os pais não apresentavam queixas clínicas. Inicialmente, avaliamos dados hematológicos e bioquímicos e a análise qualiquantitativa de hemoglobina (Hb) da família. O DNA genômico foi extraído dos leucócitos do sangue periférico com kit comercial, e o gene da globina β foi seletivamente amplificado e sequenciado. As crianças apresentavam anemia moderada (transfusão recente) com reticulocitose, e os pais, discretas alterações hematológicas (microcitose e hipocromia). As dosagens séricas de ferro estavam normais nos pais e elevadas nas crianças, enquanto as relacionadas com a hemólise, normais somente no pai. A análise das frações de Hb revelou que a HbA2 estava dentro dos valores normais nas crianças e aumentada nos pais (mãe = 5,8% e pai = 5,1%) e a HbF estava normal nos pais e aumentada nas crianças (filho = 38% e filha = 42,5%). Após o sequenciamento do gene β, foi identificada a inserção, em homozigose, de quatro nucleotídeos nas posições 291-294 [HBB:c.291_294insGCAC (p.99-103VDPEN>ARGSX)] nas duas crianças. Os pais, primos em 2º grau, apresentaram a mesma alteração em heterozigose. Conclusão: A inserção dos nucleotídeos GCAC no códon 99 induz uma parada prematura no códon 102 do éxon 2 no gene da globina β, associada ao alelo β0. Em 2021, essa sequência variante do gene β foi descrita no México em heterozigose. De nosso conhecimento, este é o primeiro relato da mutação, em homozigose, responsável pelo fenótipo de talassemia β maior descrita em uma família brasileira proveniente do estado do Ceará.
PESQUISA DE ANTICORPOS IRREGULARES NA ROTINA GESTACIONAL: IMPORTÂNCIA E APLICAÇÃO CLÍNICA
Authors: Anjos EBV , Oliveira LEF , Silva IKL , Nascimento LBS , Lima JL , Lima AS , Almeida FR , Santos JH
Published: October 2024

Objetivo: A identificação de anticorpos no perfil gestacional desempenha um papel crucial na detecção precoce de possíveis complicações imunológicas que podem afetar a saúde da mãe e do feto. A pesquisa de anticorpos irregulares (PAI) é realizada pelo teste de coombs indireto (CI), no qual é possível detectar a presença de aloanticorpos em resposta à presença de antígenos não próprios. Uma vez detectada uma PAI positiva, é importante identificar o anticorpo em questão; alguns desses anticorpos, por sua vez, são capazes de atravessar a placenta e destruir as hemácias fetais, resultando na doença hemolítica do feto e do recém-nascido (DHFRN). O presente estudo teve como objetivo determinar a prevalência de PAI positiva nas gestantes atendidas em uma operadora de saúde, bem como ressaltar a importância clínica na identificação desses anticorpos e sua relação com a DHFRN. Método: Foi realizado um levantamento de dados/resultados do exame de CI das gestantes atendidas na operadora de saúde no período de novembro de 2022 a abril de 2023 por meio de um programa de gerenciamento de resultados da unidade, utilizando os critérios: idade, sexo e CI positivos. Conclusão: Do período determinado, 361 pacientes apresentaram resultados de CI positivos, dos quais 353 correspondem a mulheres gestantes. A PAI no perfil gestacional é fundamental para detecção precoce de complicações imunológicas durante a gestação, visto que a DHFRN pode ser desencadeada pela presença de diferentes anticorpos, principalmente do sistema Rh e Kell, que são os mais imunogênicos capazes de provocar diversos graus de gravidade da doença. Dessa forma, a identificação do anticorpo proporciona uma abordagem mais segura e direcionada para o acompanhamento da gestação, melhorando os resultados obstétricos e neonatais.
¿Existe relación entre el alzheimer y la enfermedad periodontal? Una revisión tipo paraguas
Authors: Hernández-Nieto Lucía , Barrios-Ayola Francisco , Diaz-Caballero Antonio
Published: October 2024

ANTECEDENTES: el Alzheimer es una enfermedad neurodegenerativa que se identifica por ocasionar la pérdida de la memoria, el lenguaje y la disfunción cognitiva, lo cual contribuye a la reducción de las maniobras relacionadas con la higiene bucal y por consiguiente la aparición progresiva de la enfermedad periodontal, caracterizada por inflamación de las encías, sangrado, bolsas, movilidad, además de la incidencia de bacterias como la Porphyromonas gingivalis, que agrava en cierto modo el estado cognitivo de estos pacientes y se encuentra relacionada con la enfermedad periodontal. OBJETIVO: Revisar la información disponible y actual sobre la posible relación entre Alzheimer y la enfermedad periodontal para establecer un estado del arte. METODOLOGÍA: artículo de revisión sistemática tipo paraguas, artículos publicados en el rango de tiempo de 2015 a 2022, que muestren resultados acerca de la relación que existe entre estas dos enfermedades. Se realizaron búsquedas en los registros de bases de datos electrónicas, como PubMed, Science direct, Dentistry & Oral Sciences Source, MEDLINE, los registros fueron seleccionados y se aplicaron los criterios de la metodología Prisma, finalmente se escogieron trece artículos. RESULTADOS: se confirmó la relación entre Alzheimer y enfermedad periodontal, provocando en estos pacientes la pérdida dental en sus estadios más avanzados y la incidencia de bacterias vinculadas con la parte periodontal, que agrava en cierto modo el estado cognitivo de los pacientes con este tipo de condición mental. CONCLUSIÓN: existe una relación entre Alzheimer y la enfermedad periodontal, sustentado en previas investigaciones, sin embargo, hace falta más sustento en la literatura y la inclusión de ensayos clínicos aleatorizados, acerca de esta temática.
Effects of Physical Activity Level and Sedentary Behavior on the Musculoskeletal System in Young Adults
Authors: Telli Hilal , Özel Çakır Filiz
Published: October 2024

Aim: The aim of this study is to investigate the relationship between the level of physical activity and sedentary behavior in young adults aged 18-35 and to evaluate the effects of this relationship on musculoskeletal pain, posture, muscle shortness, and trunk muscle endurance.
Methods: In this cross-sectional descriptive study, conducted at the Faculty of Health Sciences of a university between March 2018 and August 2018, 219 students were included. Data were obtained by using the case report form which determines the demographic characteristics and sedentary behavior of the students, The International Physical Activity Index - short form, posture analysis form, muscle shortness evaluation form, and trunk muscle endurance evaluation form.
Results: In the study, 66.2% of patients were female and 33.8% were male. In the evaluation of physical activity level, the ratio of highly active individuals in males, and inactive and insufficiently active individuals in females was significantly higher (p <0.05). Musculoskeletal pain was significantly higher in inactive and insufficiently active individuals (p<0.001). A negative correlation existed between physical activity level and pain frequency, duration, and scores (p<0.001). There was a positive correlation between trunk endurance tests and physical activity and exercise participation. Non-exercisers showed shortening of lumbar extensor muscles and gastrosoleus, with increased thoracic kyphosis (p<0.05). Daily sitting time correlated positively with elbow, wrist, and knee pain, and lumbar lordosis (p<0.05). Those spending more time at the computer experienced higher levels of head-neck and elbow pain, pain duration, muscle shortness, thoracic kyphosis, shoulder protraction, and anterior head tilt (p<0.05).
Conclusion: In young adults, increasing physical activity and reducing daily sitting time are necessary to prevent musculoskeletal pain and reduce postural deformities.
Keywords: Musculoskeletal diseases, musculoskeletal pain, physical exertion, posture, sedentary behavior, trunk muscular endurance, young adult.
A Critical Analysis on the Low Birth Rate Problem and the Effectiveness of Relevant Policy
Authors: Yao Zhenzheng
Published: October 2024

This paper discusses the importance of the birth rate problem and the effectiveness of Chinas Three-Child policy. In order to efficiently elaborate problems, this paper analyses the issue from several perspectives. Firstly, a declining birth rate will have a negative impact on the global and domestic economic development due to the decrease in labour force. Secondly, this paper suggests that the key reason for this declining birth rate is the rising economic pressure on young people. This paper finds that China, Japan, and South Korea face the same low birth rate problem. Hence, this paper investigates the different wage levels and house prices among these East Asian countries and elaborates on the relationship associated with declining birth rates. Furthermore, this paper also discusses how to ensure the successful implementation of the Three-Child policy, and what effect the social welfare and the Three-Child policy can bring to help the society and the economy.
Bimbingan Teknis Petani Pemakai Air (P3A) JIAT Di Desa Langgea Kec. Ranomeeto Kabupaten Konawe Selatan
Authors: Sufrianto Sufrianto , Lakawa Irwan , Haryono Haryono
Published: October 2024

Tujuan Kegiatan Pengabdian Pada Masyarakat ini adalah untuk Untuk memberikan pemahaman kepada masyarakat terhadap Memberikan pemahaman kepada masyarakat setempat tentang proses pengoperasian dan pemeliharaan jaringan irigasi air tanah dan Memberikan pemahaman kepada masyarakat tentang pemeliharaan jaringan irigasi dan bangunan air. Beberapa materi penting yang di sampaikan dalam Kegiatan Pengabdian Pada Masyarakat ini yaitu Kesalahan pengoperasian dan pemeliharaan jaringan irigasi air tanah, penurunan kapasitas sumur bar diluar pengaruh kinerja pompa, perhitungan biaya untuk melaksanakan redevelopment, pengaturan air irigasi dan pembuangannya, serta metode kerja tangan untuk pembersihan saluran. Metode yang digunakan dalam kegiatan ini adalah metode ceramah dan diskusi serta penjelasan teknis terhadap detail gambar kerja dan dilanjutkan dengan kunjungan lapangan bersama para perserta. Hasil yang diperoleh dari kegiatan ini menunjukkan bahwa para petani pemakai air (P3A) di Desa Langgea Kecamatan Ranomeeto Kabupaten Konawe Selatan memiliki respon yang cukup baik terhadap kegiatan Pengabdian Pada Masyarakat oleh Tim Tenaga pengajar (Dosen) Fakultas Teknik Universitas Sulawesi Tenggara ini, dan diharapkan adanya kegiatan-kegiatan sejenis lainnya yang dapat memberikan pengetahuan dan pemahaman kepada seluruh masyarakat terhadap penerapan Ilmu Pengetahuan dan Teknologi Tepat Guna lainnya khususnya mengenai keairan
Analisis Pengaruh Green Product dan Citra Merek terhadap Minat Beli Pada Produk “The Body Shop” di Sidoarjo
Authors: Bachtiar Nadhifatul Azizah Putri , Purwanto Sugeng
Published: October 2024

Perkembangan tren kecantikan yang sedang digandrungi oleh para wanita kini telah menjadi suatu hal yang besar meliputi penggunaan skincare maupun bodycare The Body Shop sebagai salah satu pilar perusahaan yang mengedapankan produk yang menggunakan bahan alami serta citra merek yang mendukung berbagai aspek dalam minat pembelian konsumen. Tujuan dari penelitian mengetahui pengaruh Green Product dan Citra Merek terhadap Minat Pembelian dengan menggunakan objek penelitian produk The Body Shop pada masyarakat di Sidoarjo. Penelitian ini menggunakan pendekatan kuantitatif. Populasi dalam penelitian ini masyarakat yang berdomisili di Sidoarjo. Adapun sampel pada penelitian ini sebanyak 112 responden masyarakat di Sidoarjo yang mengetahui produk The Body Shop. Seluruh pengujian dengan menggunakan Aplikasi SmartPLS menunjukkan bahwa seluruh pengujian mendapatkan nilai diatas nilai yang telah diprasyaratkan agar pengujian tersebut dinyatakan reliable. Penelitian ini menggunakan desain penelitian kuantitatif, analisisi data berupa statistic deskriptif dan analisis PLS. Hasil penelitian menunjukkan bahwa Green Product berkontribusi dalam minat pembelian produk The Body Shop pada masyarakat di Sidoarjo. Kemudian pada Citra Merek berkontribusi dalam Minat pembelian produk The Body Shop di Sidoarjo.
Pengaruh Penerapan Model Pembelajaran Berdiferensiasi terhadap Kemampuan Meresensi Novel di Kelas VIII SMP TA 2023/2024
Authors: Tarigan Sania Sutari Br , Simaremare Juni Agus , Saragih Renita Br
Published: October 2024

Penelitian ini bertujuan untuk mengetahui Pengaruh  Penerapan Model Pembelajaran Berdiferensiasi terhadap Kemampuan Meresensi Novel di Kelas VIII SMP Negeri 10 Medan Tahun Ajaran 2023/2024. Penelitian ini menggunakan metode penelitian kuantitatif eksperimen dengan desain Two Group Post Test Only Control Design. Populasi dalam penelitian ini seluruh kelas VIII berjumlah 352 Siswa. Penelitian ini menggunakan dua kelas yaitu sebagai kelas kontrol dan kelas eksperimen. Teknik analisis data yang digunakan yaitu uji normalitas, uji homogenitas dan uji hipotesis. Setelah dilakukan penelitian untuk ekperimen pada kelas kontrol dan eksperimen dengan penerapan pembelajaran berdiferensiasi, diperoleh nilai rata-rata kelas kontrol 61,56 dengan simpangan baku 10,78 dan nilai kelas eksperimen rata-rata 81,25 dengan simpangan baku 9.60. Hasil uji prasyarat data kelas kontrol dan eksperimen menyatakan sampel berdistribusi normal dan homogen. Dari hasil pengujian hipotesis penelitian dilakukan uji "t" pada taraf signifikan ? =0.05 diperoleh Thitung > Ttabel = (7,63178 > 1,66980). Dengan demikian disimpulkan bahwa ada pengaruh yang signifikan pada Penerapan Pembelajaran Berdiferensiasi.
Pengaruh Metode Pembelajaran Problem Solving dan Pemamfaatan Gadget terhadap Hasil Belajar Peserta Didik pada Mata Pelajaran Matematika di Kelas III SDN 16 Tanah Garam Kota Solok
Authors: S Martini , Jamna Jamaris , Noviyanti Merry
Published: October 2024

Penelitian bertujuan untuk mengetahui pengaruh media berbantuan Quizizz dalam pembelajarna problem solving dan digunakannya gadget terhadap hasil belajar matematika siswa dalam pelajaran siswa kelas III di SDN 16 Tanah Garam Kota Solok. Jenis pemeriksaan yang digunakan adalah pemeriksaan studi semu. Teknik pengumpulan eksemplar yang digunakan adalah daya upaya sasaran sampling.  Instrumen yang digunakan bagian dalam pemeriksaan ini adalah kuesioner menjelang menangkap rekayasa gadget dan pengujian menjelang menangkap imbas mencontoh sejumlah 94 centerik. Teknik polemik petunjuk yang digunakan bagian dalam pemeriksaan ini adalah pengecekan t (pairedmost t-test) dan polemik dekadensi sederhana. Hasil pemeriksaan ini adalah thitung > ttabel, berlawanan thitung = 4,759 > ttabel = 2,048 yang berisi H1 dikabulkan dan H0 ditolak, sehingga perkiraan bagian dalam pemeriksaan ini adalah tersedia kelanjutan ideal tarbiah solusi bidang pakai sumbangan syarat eksamen terhadap imbas mencontoh aritmetika centerik bani III SDN 16 Tanah Garam Kota Solok. Pada sebab Penggunaan Gadgetdengan etik thitung sebanyak 2595 dan etik sig sebanyak 0. 036. Dari imbas termasuk tampak bahwa thitung > ttabel atau 2595 > 1765. Oleh karena itu, bisa disimpulkan bahwa rekayasa aparat beruang film dan berarti terhadap imbas mencontoh centerik. Metode tarbiah berbantuan syarat Quizzizz bagian dalam membereskan bidang dan rekayasa aparat beruang film dan berarti terhadap imbas mencontoh.
Tradisi Sakeco Tau Samawa Preservation and Innovation dalam Kolaborasi Pertunjukan Musik dan Tari Sebagai Pengembangan Pariwisata Berbasis Kesenian Masyarakat
Authors: Wulanda Gigih Alfajar Novra , Suvina Suvina
Published: October 2024

Urgensi penelitian ini adalah kurangnya kreativitas dan inovasi pada penyajian kesenian tradisional “sakeco” sehingga berdampak pada eksistensi dari kebudayaan itu sendiri. Kesenian tradisional “sakeco” merupakan kesenian daerah kabupaten Sumbawa, Nusa Tenggara Barat. Dimana kesenian ini disajikan secara sederhana dalam menembangkan lawas terdiri dari dua orang, dengan memainkan alat musik tradisional yang disebut rabana. Tembang lawas yang disajikan berisi tentang cinta, kasih, pemujaan, pengorbanan, perjuangan, perjalanan hidup, nasehat, dan sebagainya. Kesenian “sakeco” itu sendiri merupakan salah satu aset budaya lokal suku Samawa maka penting untuk melakukan inovasi penyajian sakeco Sebagai Pengembangan Pariwisata Berbasis Masyarakat. Tentunya diperlukan ide dan kreativitas serta inovasi dalam strategi penyajian sebuah karya seni pertunjukan yang menarik dan mampu mengedukasikan kesenian tradisional daerah. Tujuan penelitian ini untuk pengembangan pariwisata berbasis kesenian masyarakat Sumbawa dalam preservation and innovation tradisi sakeco yang dikolaborasikan pada pertunjukan musik dan tari. Penelitian ini mampu menciptakan pengalaman baru pada penyajian karya seni pertunjukan sakeco. Penelitian ini adalah penelitian kualitatif berbasis seni dengan metode penciptaan untuk menghasilkan inovasi baru dalam keilmuan seni pertunjukan elaborasi musik dan tari. Tahap pengumpulan data berbasis data primer dan data skunder yang meliputi; tahap observasi, tahap wawancara, tahap studi pustaka, dan tahap dokumentasi. Proses kerja kreativitas melalui tahapan ide gagasan, komposisi (susunan), dan produk/hasil karya (output).
Tradisi Meja Makan sebagai Media Komunikasi Interpersonal salam Keluarga
Authors: Wattimena Demsy , Latuihamallo Anthonio Johan
Published: October 2024

Urgensi  dari penelitian ini akan menjadi masukan bagi mitra peneliti yakni Pemerintah Negeri Porto, Pemerintah Negeri Haria dan Pemerintah Negeri Ulath. Bertujuan menumbuhkan kesadaran masyarakat untuk kembali menjalankan tradisi makan di meja makan secara sakral. Metode yang digunakan adalah metode kualitatif dengan pendekatan fenomenologi.  Fenomenologi  melibatkan pengujian yang teliti dan seksama pada kesadaran pengalaman manusia. Konsep utama dalam fenomenologi adalah makna. Makna merupakan isi penting yang muncul dari pengalaman kesadaran manusia.  Luaran dari penlitian ini akan di publikasi pada jurnal nasional terakreditasi sinta 4 (Jurnal Ilmiah IlmuPendidikan) hasil penelitian Komunikasi interpersonal dalam keluarga merupakan bentuk komunikasi yang terjalin  antara Ayah, ibu anak serta anggota keluarga lainnya yang berada dalam keluarga itu. Adanya suatu fenomena  dapat mengintegrasi  komunikasi dalam keluarga secara intensif yakni tradisi makan di meja makan.  Orang tua memberikan dan mengajarkan  tentang nilai, norma , pengetahuan, sikap dan harapan kepada anak-anak.  Melalui media meja makan maka komunikasi interpersonal  antara orang tua dan anak dapat terjalin dimana meja makan bukan hanya sebagai tempat untuk duduk makan bersama namun lebih dari itu meja makan digunakan sebagai media  terjalinnya komunikasi   interpersonal orang tua dengan anak-anak.
Penerapan Model Pembelajaran Matematika Berbasis Masalah Dikaji dari Komunikasi dan Disposisi Matematis pada Peserta Didik SMA
Authors: Riyadi Slamet , Rif’at Mohamad , Nurfadilah Nurfadilah
Published: October 2024

Penelitian ini bertujuan untuk menganalisis tingkat komunikasi dan disposisi matematis peserta didik di sekolah menengah atas dengan metode deskriptif kuantitatif analitis berorientasi pada pemecahan masalah. Subjek dalam penelitian merupakan peserta didik kelas XI IPA di SMAN 1 Matan Hilir Utara. Soal tes komunikasi yang dikembangkan menunjukkan validitas rata-rata 0,75 (kategori tinggi) dan reliabilitas 0,55825 (kategori sedang). Hasil analisis menunjukkan nilai rata-rata komunikasi dan disposisi matematis, melalui pembelajaran berbasis masalah (PBM) cukup tinggi, dengan disposisi matematis memiliki rata-rata tertinggi. Sebaran data menunjukkan variasi yang berbeda, dengan disposisi matematis memiliki sebaran paling moderat dan PBM paling rendah, serta distribusi nilai yang mendekati normal. Hasil Uji hipotesis menunjukkan bahwa komunikasi matematis (X1) dan disposisi matematis (X2) masing-masing memiliki pengaruh signifikan terhadap PBM, dengan nilai signifikansi 0,00 (< 0,05) dan nilai t hitung yang lebih besar dari t tabel. Pengaruh simultan kedua variabel independen terhadap PBM juga signifikan, dengan nilai F hitung 2412,036 (> F tabel 3,40). Model regresi yang diperoleh adalah Y=1,122+0,520X1+0,469X2, menunjukkan hubungan linear signifikan antara komunikasi dan disposisi matematis terhadap PBM. Penelitian ini menunjukkan bahwa pembelajaran berbasis masalah memiliki dampak positif dan konsisten terhadap peningkatan komunikasi dan disposisi matematis peserta didik.
Implementasi Nilai-Nilai Islam dalam Kepemimpinan Pendidikan: Studi Kasus di MTs Negeri 2 Palembang
Authors: Kurnia Riza , Afriantoni Afriantoni , Annur Saipul
Published: October 2024

Penelitian ini bertujuan untuk menganalisis implementasi nilai-nilai Islam dalam kepemimpinan pendidikan di MTs Negeri 2 Palembang. Nilai-nilai seperti amanah, adil, musyawarah, ukhuwah, dan ihsan diidentifikasi sebagai prinsip utama yang diterapkan oleh para pemimpin madrasah dalam menjalankan tugas mereka. Studi ini menggunakan metode kualitatif dengan pendekatan studi kasus. Data diperoleh melalui wawancara mendalam, observasi partisipan, dan analisis dokumen. Hasil penelitian menunjukkan bahwa integrasi nilai-nilai Islam dalam kepemimpinan pendidikan memiliki dampak positif pada peningkatan kualitas akademik, pembentukan karakter peserta didik, dan penguatan motivasi tenaga pengajar. Strategi yang digunakan meliputi program pengembangan profesional berkelanjutan, keteladanan, serta integrasi nilai-nilai Islam dalam kurikulum dan kegiatan ekstrakurikuler. Tantangan seperti resistensi terhadap perubahan dan keterbatasan sumber daya diatasi melalui pendekatan partisipatif dan inovatif. Implementasi nilai-nilai Islam dalam kepemimpinan terbukti tidak hanya mampu meningkatkan prestasi akademik siswa, tetapi juga menciptakan lingkungan pendidikan yang kondusif bagi pengembangan karakter Islami yang kuat. Dengan demikian, penelitian ini menegaskan pentingnya integrasi nilai-nilai Islam dalam kepemimpinan pendidikan untuk menghasilkan peserta didik yang unggul dan berakhlak mulia.
Pengaruh Beban Kerja dan Lingkungan Kerja terhadap Kinerja Pegawai di Kelurahan Arab Kenangan Kabupaten Sumbawa Barat
Authors: M. AR Muslimin , Yamin Ahmad , Najamuddin Najamuddin
Published: October 2024

Peneltian ini bertujuan untuk mengetahui pengaruh beban kerja dan lingkungan kerja terhadap kinerja pegawai Kelurahan Arab Kenangan dalam memberikan pelayanan kepada Masyarakat. Penelitian ini menggunakan metode analisis kuantitatif dengan mengumpulkan data dilakukan dengan menyebarkan kuisioner dari semua pegawai Kelurahan Arab Kenangan sebanyak 36 orang. Regresi linier berganda digunakan untuk menganalisis pengaruh hubungan antara beban kerja dan lingkungan kerja terhadap kinerja pegawai kelurahan Arab Kenangan. Hasil penelitian menunjukkan bahwa baik beban kerja maupun lingkungan kerja memiliki pengaruh positif terhadap kinerja pegawai, dengan Lingkungan Kerja memberikan kontribusi yang lebih besar yaitu 80,60 % dibandingkan beban kerja yaitu sebesar 09,20%. Hal ini menunjukkan bahwa perbaikan lingkungan kerja lebih signifikan dalam meningkatkan kinerja pegawai dibandingkan dengan perubahan beban kerja. Secara simultan, kedua variabel ini berkontribusi terhadap perubahan kinerja pegawai, namun ada faktor lain di luar model ini yang juga memengaruhi kinerja, sebagaimana tercermin dari konstanta sebesar 1,689.
Penerapan Analisis SWOT Dalam Menentukan Strategi Pemasaran Jasa Pendidikan di Pondok Pesantren Al-Kinanah Kota Jambi
Authors: Isnaini Wahyu , Elwiddah Minnah , Musli Musli
Published: October 2024

Penelitian ini bertujuan untuk mendeskripsikan peneranapan analisis SWOT dalam menentukan strategi pemasaran jasa pendidikan, adapun pemilihan lokasi penelitian dilakukan di Pondok Pesantren Al-kinanah Kota Jambi. Penelitian ini merupakan penelitian kualitatif dengan subjek penelitian pimpinan pondok, kepala sekolah, staff kesekretariatan, guru dan santri Pondok Pesantren Al-kinanah Kota Jambi. Berdasarkan hasil penelitian, diperoleh hasil berupa: (1) Analisis SWOT di Pondok Pesantren Al-kinanah Kota Jambi; a) kekuatan utama adalah tenaga pendidik dan kependidikan yang kompeten, b) Kelemahan utama yang dimiliki adalah keadaan sarana dan prasarana yang belum cukup tertata, c) Peluang utama yang dimiliki ialah minat masyarakat untuk memperoleh pendidikan Islam semakin meningkat, d) Ancaman utama yang dimiliki berupa adanya sekolah Islam swasta yang berkualitas baik. (2) Strategi pemasaran jasa pendidikan yang ditetapkan pimpinan Pondok Pesantren Al-kinanah Kota Jambi adalah dengan menggunakan berbagai jenis pemasaran baik secara online maupun secara offline. (3) Evaluasi analisis SWOT di Pondok Pesantren Al-kinanah Kota Jambi, hasil skor analisis SWOT melalui matriks faktor internal dan eksternal di Pondok Pesantren Al-kinanah Kota Jambi diperoleh hasil akhir skor IFAS sebesar 5,2. Sementara skor akhir EFAS adalah sebesar 2,25. Hasil analisis ini mebawa Pondok Pesantren Al-kinanah Kota Jambi berada pada kuadran SO  (strenght-opportunity) yang mendukung kebijakan pertumbuhan yang agresif (growth oriented strategy), yakni memanfaatkan kekuatan internal lemabaga untuk merebut peluang eksternal sebesar-besarnya.
Analisis Tingkat Efektivitas Program Inseminasi Buatan (IB) terhadap Perkembangan Ternak Sapi di Kabupaten Sumbawa Barat
Authors: Sama Sama , Yamin Ahmad , Anggara Mietra
Published: October 2024

Inseminasi Buatan merupakan salah satu teknologi dalam reproduksi ternak yang memiliki manfaat dalam mempercepat peningkatan mutu genetik ternak, mencegah penyebaran penyakit reproduksi yang ditularkan melalui perkawinan alam,Efektivitas program Inseminasi Buatan lebih digalakkan karena program ini memberikan nilai tambah cukup besar bagi sumber pendapatan asli daerah dan bagi peternak berupa meningkatnya populasi dan produktivitas ternak, mempercepat jarak kelahiran ternak, memperoleh keturunan jenis ternak yang unggul sehingga meningkatkan kesejahteraan. Pelaksanaan Inseminasi Buatan sapi Tahun 2022 di Kabupaten Sumbawa Barat (S/C; 1,9, CR; 41,3%, NRR; 66,2%) dan pelaksanaan Inseminasi Buatan Tahun 2023 (S/C; 1,8, CR;42,1%, NRR; 43,1%). Sehingga tidak ada tingkat efektivitas program inseminasi buatan terhadap perkembangan ternak sapi di Kabupaten Sumbawa Barat. Struktur populasi sapi di Kabupaten Sumbawa Barat didominasi oleh ternak betina dengan karakteristik peternak didominasi oleh laki-laki dengan rentang umur 44-53 Tahun.Dilakukannya inseminasi buatan untuk mendapatkan bibit sapi berkualitas tanpa harus mempertahankan pemeliharaan pejantan di tempat terbatas dan juga pemeliharaan betina indukan dengan cara pemilihan bibit, recording, judging dan replacement stock untuk menghasilkan indukan yang baik.
Dissenting Opinion Para Hakim dalam Pengadilan: Fungsi dan Ancamannya
Authors: Weruin Urbanus Ura
Published: October 2024

Dalam praktik hukum, disseting opinion para hakim merupakan hal yang wajar dan biasa dalam mengadili perkara. Dissenting opinion para hakim di pengadilan pun memiliki fungsi yang penting. Pertama, dissenting opinion menerapkan prinsip demokrasi deliberatif dalam pengadilan. Kedua, dissenting opinion memberikan stimuluas bagi para hakim untuk mengekspresikan dan mempublikasikan pertimbangan yang rasional, kritis, dan objektif sebagai bentuk integritas individu dan pertanggungjawaban hakim terhadap publik. Ketiga, dissenting opinion berkontribusi bagi pengembangan hukum di masa depan. Tetapi dissenting opinion para hakim di pengadilan pun dianggap membahayakan hukum, karena dissenting opinion menyuburkan perasaan ambigu (ambiguous feelings) dalam hukum; penalaran, pertimbangan, dan penerapan hukum menjadi sangat individualistik; mengancam eksistensi lembaga peradilan; dan mengorbankan koherensi dan kepastian hukum. Secara epistemologis, demi keadilan dan kebenaran hukum yang reasonable, diperlukan diskursus deliberatif dan pertimbangan ‘meta-constitusional’ bagi para hakim yang mengikuti suara mayoritas atau para hakim yang mengajukan dissenting opinion guna mewujudkan keseimbangan antara kebenaran dan keadilan sebagai tujuan hukum. Karena pro-kontra dan plus-minus yang menyertai praktik dissenting opinion di pengadilan dapat mengancam kebenaran dan kepastian hukum. Artikel hasil penelitian kepustakaan ini menggunakan metode content analysis. Berdasarkan catatan-catatan yang dibuat dari kepustakaan yang ada, dirumukan gagasan-gagasan sistematis tentang topik tersebut sebagai hasil penelitian ini.
Thực trạng kiến thức chăm sóc, dự phòng viêm phổi của bà mẹ có con dưới 5 tuổi điều trị tại Bệnh viện Trẻ em Hải Phòng năm 2024 và một số yếu tố liên quan
Authors: Đỗ Thị Thùy Dung , Lê Thanh Tùng
Published: October 2024

Mục tiêu: Mô tả thực trạng kiến thức chăm sóc, dự phòng viêm phổi của bà mẹ có con dưới 5 tuổi điều trị tại Bệnh viện Trẻ em Hải Phòng năm 2024 và một số yếu tố liên quan.
Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 200 bà mẹ có con dưới 5 tuổi mắc viêm phổi đang điều trị tại Khoa Hô hấp - Bệnh viện Trẻ em Hải Phòng từ tháng 04 năm 2024 đến tháng 06 năm 2024.
Kết quả: Tỷ lệ các bà mẹ có kiến thức đạt về bệnh, dấu hiệu bệnh viêm phổi là 58,0%, kiến thức đạt về chăm sóc trẻ viêm phổi là 79,5%, các bà mẹ có kiến thức đạt về dự phòng bệnh viêm phổi tương đối cao chiếm tỷ lệ 94,5%, tỷ lệ các bà mẹ có kiến thức chung đạt là 68,5%. Các yếu tố liên quan đến kiến thức chăm sóc và dự phòng viêm phổi của bà mẹ sau khi phân tích hồi quy đa biến là: nhóm tuổi, trình độ học vấn, nguồn thông tin nhận từ nhân viên y tế, nguồn thông tin nhận được từ internet. Sự khác biệt có ý nghĩa thống kê với p < 0,05.
Kết luận: Kiến thức chăm sóc và dự phòng viêm phổi của bà mẹ có con dưới 5 tuổi điều trị tại Bệnh viện Trẻ em Hải Phòng năm 2024 tương đối tốt. Cần tăng cường hỗ trợ thông tin, truyền thông giáo dục sức khỏe đến nhóm đối tượng bà mẹ có độ tuổi dưới 25 tuổi và có trình độ học vấn từ trung học phổ thông trở xuống với những nội dung đơn giản, dễ hiểu, dễ nhớ.
Correlation of Non-Mass Breast Lesions on Ultrasound with Histopathology
Authors: Hameed Hind , Fareed Sahar
Published: October 2024

Background and Aim: Breast cancer is the most common invasive cancer among women worldwide. In Iraq, the incidence of new breast cancer cases significantly increased from 52.00 per 100,000 in 2000 to 91.66 per 100,000 in 2019. The goal is to develop standardized reporting criteria for NMLs on ultrasound to improve patient management.
Methods: A cross-sectional study at AL-Yarmouk Teaching Hospital in Baghdad included 55 female patients with NMLs. Participants underwent evaluations using ultrasound, with mammographic correlation when applicable. Lesion characteristics, such as size, location, echogenicity, and associated features, were documented according to BI-RADS lexicon. Tissue Core Biopsy (TCB) was performed to obtain samples for histopathological analysis. Ethical approval and informed consent were obtained, ensuring data confidentiality and participant privacy.
Results: Among the 55 patients, 60% of NMLs were benign, 25.5% were malignant, and 14.5% had upgrade potential. Significant associations were found between ultrasound characteristics (e.g., distribution and echogenicity) and histopathological outcomes, with segmental distribution being more common in malignant lesions. Mammographic features such as calcifications and architectural distortion also strongly correlated with malignancy.
Conclusion: The integration of advanced ultrasound technology has improved the detection of NMLs, crucial for early breast cancer detection. However, these lesions often mimic surrounding tissues, leading to potential false positives. Future research should focus on standardizing ultrasound interpretation of NMLs to enhance diagnostic accuracy and patient management.
Posterior leaflet division and augmentation technique for repairing rheumatic mitral valve
Authors: Sahin Mehmet , Kuralay Erkan
Published: October 2024

Leaflet mobilization is an important part of rheumatic mitral valve disease repair. Conventional commissurotomy techniques may not allow leaflet mobilization in some patients. We described a new technique for adequate mobilization of the posterior leaflet. First, we performed mitral commissurotomy in both commissures. The posterior leaflet was then separated from the posterior annulus from the anterolateral commissure to the posteromedial commissure. Tertiary and secondary chordae were removed. The posterior leaflet was divided vertically into two parts. After removal of the fibrous attachments, the pericardial patch was sutured to the entire posterior leaflet. The artificial chordae were re-implanted in the neo-P2 region of the porterior leaflet to achieve good coaptation. We did not use a ring after the mitral valve repair was completed.
Reproductive endocrine changes in relation to calcium metabolism in layers experimentally infected with Escherichia coli
Authors: Adeke Joshua , Abdulsalam Hassan , Gambo Halima , Gadzama Joseph , Gurumyen George , Chabiri Ladi , Markus Talatu , Adamu Sani , Esievo King
Published: October 2024

Aim: This study determined calcium metabolism-related reproductive endocrine changes associated with Escherichia coli (E. coli) infection in layer chickens.
Methods: A total of 20 laying chickens (20 weeks old) were acquired and assigned, into two groups (infected and controlled) of 10 layers each. Birds in the infected group were challenged with 0.5 ml of bacterial aliquot containing 109 colony forming units (CFU) of the bacteria, intratracheally. Two (2) ml of blood were collected from each bird in both groups and used for biochemical analyses.
Results: Escherichia coli infection in layers caused decrease in mean oestrogen profile from day 6 reaching the lowest value (332.6 ± 5.41 pg/ml) on day 28 post infection (pi) that differed significantly (p < 0.05) from the corresponding value in the control group. The mean plasma progesterone profile and mean plasma calcium concentration in the infected group decreased from day 4 and 6 pi, respectively, and reached the lowest significant (p<0.05) values (94.8 ± 1.98 pg/ml and 1.61 ± 0.11 mmol/L, respectively) on day 28 and 14 pi, respectively, which was significantly different (p < 0.05) from that in their corresponding control group. The mean plasma phosphate concentration and mean parathormone profile increased from day 6 to a significantly (p < 0.05) higher levels (1.64 ± 0.12 mmol/L and 31.04 ± 0.80 pg/ml, respectively) on day 14 and 21, pi respectively.
Conclusion: The E. coli-induced reproductive endocrine and clinicopathological changes recorded in present study may be responsible for the reported reproductive disorders in layers infected with E. coli.
The potential of agricultural management to alleviate extreme weather impacts on Swedish crop production
Authors: Sjulgård Hanna
Published: October 2024

Climate change, stagnating crop yields and the increased demand for food pose challenges to future agriculture. Therefore, it is of great importance to assess the potential of agricultural management practices to mitigate the effects of climate change, and especially extreme weather events, on crop productivity. In this thesis, I assessed (1) the spatiotemporal patterns of crop species diversity and crop yields, (2) the vulnerability of crops to extreme weather and the importance of soil properties in mitigating such impacts, and (3) the influence of agricultural management on soil health indicators in Sweden. The analysis of historical crop data revealed an increase in crop diversity from the north to the south of Sweden, in line with increasing temperatures, implying that climatic conditions limit the diversity of crops that can be grown. A continued increase in cereal yields in southern Sweden since the 1960s, and an increase over time in crop diversity in several counties, indicate a potential also for future improvements. Crop yields were shown to be sensitive to excess water and favoured by increased temperatures in northern Sweden, while in southern Sweden, drought effects were more pronounced and increased temperatures had a negative impact on crop yields. Estimates based on satellite images showed a lower winter wheat growth rate and lower peak green leaf area index during drought compared to normal weather conditions. A high importance of plant available water during drought was shown by faster growth of winter wheat on fields with higher plant available water capacity, and by greater spring-sown cereal yield losses on lighter soils at the county level. On-farm analyses showed that higher crop rotational diversity, lower tillage intensity, higher use of organic fertilizers and less fungicide use were associated with improved soil health, and crop yields were influenced by organic matter content, wet aggregate stability and bulk density. Overall, this thesis suggests that targeted site- and crop adaptations are needed to mitigate the effects of extreme weather events on crop productivity.
A comparative study of self-collected versus clinician-collected specimens in detecting high-risk HPV infection: a prospective cross-sectional study
Authors: Parapob Natnipa , Lekawanvijit Suree , Tongsong Theera , Charoenkwan Kittipat , Tantipalakorn Charuwan
Published: October 2024

Objective The primary objective of this study was to compare the detection rate of high-risk human papillomavirus (HPV) infection between self-sampling to collect vaginal specimens and clinician sampling to collect cervical specimens, as well as the correlation between the two techniques. The secondary objective was to assess satisfaction with selfsampling for HPV testing.Methods From October 2021 to September 2022, women positive for HPV 16/18 and other 12 high-risk HPV genotypes and cytological Ascus were enrolled. All participants were instructed on the method for self-collection of HPV samples. Self-collected vaginal samples and clinician-collected cervical samples were subjected to HPV DNA typing.Results Paired self- and clinician-collected specimens were obtained from 104 women with positive HPV-positive results. The detection rate of high-risk HPV infection was comparable between the two techniques: 79/98 (80.6%) vs. 81/98 (82.7%) for the self-sampling and clinician-sampling techniques, respectively (McNemar’s test; P=0.774). The agreement in detecting HPV infection was substantial, with a kappa coefficient of 0.75. More than 90% of the participants rated self-collection as satisfactory to very satisfactory because of its convenience and safety. Regarding methods of further follow-up, 51% of the participants chose self-sampling, whereas the remaining participants preferred collection by clinicians. No intervention-related complications were observed.Conclusion The self-sampling technique for HPV testing was as effective as the clinician-sampling technique, and both techniques were substantially correlated in detecting high-risk HPV infection. The self-sampling method appears to be highly satisfactory and may provide better compliance for the detection of cervical HPV infection.
AÇÃO DA ALOE VERA NO TRATAMENTO DOS EFEITOS ADVERSOS OCASIONADOS PELA RADIOTERAPIA: UMA REVISÃO INTEGRATIVA DA LITERATURA
Authors: Ferreira Felipe Silva , Bezerra Maria Beatriz França , Franco Fernanda Mayara de Souza , Silva Maressa Samai Pinheiro , Lima Loyane Figueiredo Cavalcante , Cabral Simone do Amaral Monteiro , Sarmento Karen Mickaele Vale de Queiroga , Silva Michel Siqueira da
Published: October 2024

Introdução: A radioterapia é amplamente utilizada no tratamento do câncer, mas frequentemente causa efeitos colaterais, como dermatite, mucosite e proctite aguda. A Aloe Vera tem sido usada por suas propriedades terapêuticas em condições inflamatórias, e este estudo busca descrever sua eficácia no manejo dos efeitos adversos da radioterapia. Objetivo: Avaliar a eficácia da Aloe Vera na prevenção e tratamento de efeitos colaterais induzidos pela radioterapia em pacientes oncológicos. Metodologia: Realizou-se uma revisão integrativa da literatura nas bases de dados PubMed, Scopus e Cochrane, incluindo artigos publicados entre 2004 e 2022, com foco em ensaios clínicos randomizados, autocontrolados e duplo-cego. Resultados: Foram incluídos 8 estudos na revisão, dos quais 50% eram ensaios clínicos randomizados. Os resultados demonstraram que a Aloe Vera tem potencial na prevenção da proctite aguda e mucosite, mas não apresentou benefícios significativos na prevenção da dermatite induzida por radioterapia. Conclusão: A Aloe Vera mostrou-se promissora no manejo de certos efeitos adversos da radioterapia, mas são necessárias mais pesquisas para confirmar sua eficácia e explorar seu uso em diferentes contextos clínicos.
Çok Kültürlü Ortamlarda Afet Yönetimi ve Sosyal Hizmet
Authors: Akdemir Zeynep
Published: October 2024

Bu makalede kapsamlı ve çok yönlü bir yaklaşımla afetlerin sosyal, psikolojik, ekonomik ve kültürel etkileri ele alınmıştır. Çalışma kapsamında özellikle afetlerin çok kültürlü toplumlar üzerindeki etkilerine odaklanarak, kültürel çeşitliliğin afet risk yönetimi ve müdahalesi üzerindeki rolüne vurgu yapılmıştır. Bu çalışma kapsamında ilk olarak afetlerin doğa ve insan kaynaklı olmak üzere iki temeL gruba ayrıldığı ve bu afet türlerinin alt kategorilere ayrıldığı belirtilerek özellikle afetlerin toplumlar üzerindeki psikolojik etkileri ve bu etkilerin kültürel faktörlerden nasıl etkilendiğinin de üzerinde durulmuştur.
Çalışmada ayrıca afetlerin çok kültürlü toplumlar üzerindeki etkilerini azaltmak için yapılabilecek politika ve müdahale stratejilerine değinilerek, bu stratejilerin çok kültürlü toplumları dikkate alarak kültürel duyarlılık çerçevesinde geliştirilmesi gerektiği vurgulanmıştır. Afet yönetimi, risk iletişimi gibi konuların kültürel çeşitlilik bağlamında ele alınması gerektiğine vurgu yapılmıştır.
Managing Adverse Events in Clinical Trials with R and Shiny
Authors:   Programmer Analyst at Thermofisher Scientific, USA, Uttiramerur Arvind
Published: October 2024

Adverse events (AEs) are critical occurrences that can significantly impact patient safety and the overall success of clinical trials. Effective management of AEs is essential for ensuring regulatory compliance and safeguarding participants' well-being. This paper explores the integration of R and Shiny as innovative tools for the real-time monitoring, visualization, and analysis of AEs in clinical trials. By leveraging R’s robust statistical capabilities and Shiny’s interactive interface, researchers can enhance data management processes, facilitate informed decision- making, and foster collaboration among stakeholders. A case study is presented to illustrate the practical application of R Shiny in tracking AEs, demonstrating its effectiveness in improving trial outcomes and ensuring patient safety. The findings emphasize the need for adopting dynamic data analysis tools to optimize adverse event management in the evolving landscape of clinical research. KEYWORDS Adverse Events, Clinical Trials, R, Shiny, Data Management, Visualization, Real-Time Monitoring, Patient Safety.
PR015-23205-R01 Literature Review - Advances in Plasma Technology
Authors: Mangum Josh
Published: October 2024

This report presents a comprehensive literature review of plasma-based technologies with potential applications in reducing emissions from pump and compressor stations in oil and gas pipeline infrastructure. The study focuses on lean burn natural gas engines commonly used in these stations and explores various plasma technology integration options. It evaluates the effectiveness of these technologies in reducing key pollutants such as nitrogen oxides (NOx), carbon monoxide (CO), and unburned hydrocarbons. Furthermore, this report addresses the practical limitations and challenges associated with integrating plasma technologies into existing pump and compressor station engines. It considers factors such as power requirements, system integration complexity, costs, and technical maturity. The findings provide valuable insights for industry stakeholders, researchers, and policymakers involved in emissions reduction efforts in the oil and gas sector. By highlighting both the promising aspects and the hurdles of plasma-based technologies, this report aims to guide future research and development initiatives in this field.
PR214-213800-R01 Evaluation of API RP 1183 Dent Fatigue Analyses using In-Service Dents Data
Authors: Tiku Sanjay , Rana Arnav , John Binoy
Published: October 2024

The objective of this project is to validate the existing mechanical damage (MD) assessment and management tools based on in-service field dents data provided by pipeline operators. The data provided included in-line inspection (ILI), dent geometry data, operating pressure history data and in-ditch inspection observations. The dent fatigue life analysis tools were developed on behalf of Pipeline Research Council International (PRCI), Interstate Natural Gas Association of America (INGAA), Canadian Energy Pipeline Association (CEPA), other research organizations and individual pipeline operators and are included in API Recommended Practice (RP) 1183 (1). Since the assembly of API RP 1183, PRCI has continued its mechanical damage strategic research priority in the development of a greater understanding of the behavior of mechanical damage and the production of data to support engineering assessment.

The research work included the following series of tasks:

- Collect and collate mechanical damage field data provided by various pipeline operators.

- Implement the fatigue life screening and assessment approaches using the provided dent geometry and pressure loading data.

- Validate the fatigue life assessment results against the in-ditch inspection data. The data included presence of through wall cracks in dents resulting in leaks, location of surface cracks within dents and co-incident features like welds, corrosion, or gouges.
J.S. Bach’s method of playing the clavier and its transformation into modern piano pedagogy and performance
Authors: Svyrydenko Natalya
Published: October 2024

Music pedagogy as a practical field of activity has a long history. Having become professional, keyboard instruments - the organ, harpsichord – have a significantly longer lifespan than the pianoforte. Piano culture inherited not only the musical material of its great predecessors but also some valuable pedagogical instructions for the practical implementation of this material. Nowadays, these unique sources of information are sometimes regarded as archaic, relevant only to the instruments on which they were performed, but they still provide a key approach to thinking concerning musical material for its correct performance. Such valuable sources of information for modern piano performers include the theoretical works of F. Couperin, J.S. Bach and C.F.E. Bach. Understanding the primary sources of information concerning modern piano art regarding the achievements gained on the path of improving performance under the influence of reasonable pedagogy can significantly improve the culture of performance, which indicates the effectiveness of the teacher’s work.