bluuebunny/crossref_metadata_2025 huggingface dataset:
FACTORS OF THE INFORMATION SUPPORT SYSTEM ORGANIZATION AT AN INDUSTRIAL ENTERPRISE
Authors:   Perm Branch of the Institute of Economics of the Ural Branch of the Russian Academy of Sciences, Perm, Bochkarev A. , Malyshev E. ,   St. Petersburg State Marine Technical University, St. Petersburg
Published: December 2022

The special importance of ICT in the management of industrial enterprises is manifested in the demand of the management process, in particular in identifying factors that affect the efficiency of economic activity and their assessment. The object of the research is an industrial enterprise as an organizational system. The subject of the research is the methods of improving the information management system of an industrial enterprise. The purpose of the research is to improve the information management system of an industrial enterprise based on the analysis of key parameters of the information support of an industrial enterprise (ISIE) management subsystems. The following tasks have been identified and solved in order to achieve the set research goal: in the process of analyzing scientific approaches to identify the specifics and shortcomings of existing solutions in the areas of information management of industrial enterprises; evaluate the ISIE management system according to the proposed criteria on the basis of the author's DETA matrix systematizing the evaluation factors of the information support management system of an industrial enterprise; to develop a method for assessing the compliance of performance criteria with key parameters of information management subsystems of an industrial enterprise (factors of the organization of the information support system of an industrial enterprise). Research methodology. At the same time, for domestic industrial enterprises, taking into account difficult economic conditions, it is necessary to organize an effective management process in achieving financial, economic and production indicators, which, in turn, raises the responsibility and competence level of functional managers associated with the constant receipt of information coming from both external channels and internal sources. To characterize the modern information environment of an industrial enterprise, we will analyze the use of ICT in the Russian Federation, the Volga Federal District and the Perm Region. In this regard, we consider it relevant and necessary to develop methodological and practical aspects of IOPP in the direction of: development of evaluation tools; application of factor analysis of the organization of the information support of the enterprise; creating a concept and building models of the organization of enterprise processes.
Topic Analysis in TOEIC Courses in College by LDA Topic Modeling
Authors:   British And American Language And Literature Association Of Korea, Kim Sojeong
Published: December 2022

The purpose of this study is to investigate the TOEIC research topics in college from 2000 to 2022 in Korea. The total 184 papers were collected and analyzed by LDA (Latent Dirichlet Allocation) topic modeling. The results are as follows: The number of TOEIC papers has increased significantly since 2011. By analyzing LDA topic modeling, 12 topics were identified and categorized into two major topics: teaching and learning methods and learner factors. In teaching and learning method category, there were satisfaction with online lectures (T1), listening strategy (T2), reading and grammar (T3), TOEIC intensive program (T4), vocabulary learning (T6), speaking (T10), and teaching method (T11). In learner factors category, there were factors affecting TOEIC course (T5), affective factors and proficiency (T7), learning style and self-directed learning (T8), self-error analysis and report (T9), and achievement and motivation by proficiency level (T12). This study is meaningful in that it covers the 20 years of TOEIC research by LDA topic modeling and hopes to provide useful and meaningful analysis for researchers.
University EFL Students’ Perceptions on Online Instruction and Self-Regulated Learning during the Covid-19 Pandemic
Authors:   British And American Language And Literature Association Of Korea, Kim Youngsang
Published: December 2022

This qualitative research critically explored how EFL students perceived online instruction and how they managed their online learning, centering around the processes in online courses and learning activities in which learners are required to become engaged. In-depth interviews with 15 participants were conducted in order to capture their lived experiences in the wake of the emergent, unprecedented learning setting. Findings are as follows: (i) All of them were found to unanimously prefer asynchronous online instruction over synchronous one; (ii) In the use of self-regulated learning strategies, individual differences were found, which led to a high degree of test anxiety on the parts of those who did not use self-regulated learning strategies actively. Instructional implications with respect to these findings were discussed.
Educación hacker y alfabetización mediática e informacional: nuevas alianzas entre el alumnado universitario y el plagio en internet
Authors: Cuevas Salvador Jesús
Published: December 2022

Para afrontar el problema del plagio en internet, se define el objetivo de investigación: activar la actitud hacker a través de las competencias de alfabetización mediática e informacional (AMI) para establecer alianzas con la técnica de copiar y pegar en el proceso de comprensión y creación de contenidos sobre la Agenda 2030, en el alumnado del Máster en Profesorado durante el curso 2021-2022. La muestra no probabilística, formada por 60 estudiantes. La metodología investigación acción, cuasi-experimental, enfoque cualitativo, con un fin exploratorio sobre la actitud hacker en el aula y confirmatorio al medir el aprendizaje. En el análisis de contenido de la encuesta inicial y los proyectos finales, el 55% del alumnado muestra activismo por el desarrollo sostenible, el 75% ha conseguido procesar la información de internet y el 60% ha afrontado el plagio de las fuentes de información consultadas. Las alianzas entre la actitud hacker, las competencias AMI y la técnica copiar y pegar han contribuido a capacitar al alumnado para tomar conciencia de las emociones que deben derivarse en la construcción del pensamiento crítico, para convertir el proceso cognitivo de la comprensión en nuevas fuentes de satisfacción que impulsan la iniciativa hacker.
La genética mendeliana de secundaria a través del laboratorio virtual
Authors: Robles Moral Francisco Javier , Martínez Ballesteros Alejandro
Published: December 2022

En los últimos años, las investigaciones muestran un creciente desinterés por parte de los alumnos en el estudio de las ciencias. Dos de los factores que provocan esta situación son, por un lado, la continuidad que se da en la práctica docente a métodos tradicionales, alejada de las recomendaciones de las investigaciones didácticas y, por otro lado, la escisión entre teoría y práctica, tan importante en la enseñanza de ciencias. Por tanto, se hace necesario la búsqueda de estrategias didácticas eficaces y actualizadas a la realidad presente y una mayor y mejorada integración de las actividades de carácter práctico y experimental. Bajo este contexto, la genética es uno de los contenidos del currículum de biología que se valora entre los más importantes y, a su vez, complicados de aprender. Esta investigación ha tenido como objetivo evaluar una propuesta didáctica basada en el uso de un laboratorio virtual para el estudio de genética mendeliana en 4o de la ESO. Los resultados obtenidos muestran que la propuesta ha resultado ser interesante y motivadora para los alumnos, ha permitido que adquieran, en su mayoría, los conocimientos básicos necesarios y que amplíen ciertos contenidos sin la ayuda directa del profesor.
Çanakkale Ayvacık İlçesi Halı Motiflerinin Günümüz Seramik Sanatına Yansıması
Authors: Savaş Fulya , Aksoy Aslı
Published: December 2022

Çağlar boyunca bilgiyi taşımak, iletişim kurmak ve fikirleri aktarmak için kullanılan sembollerden türetilen, geçmişinden getirdiği birikimleri sanatın her alanına yansıtan motifler, Geleneksel Türk Sanatları olarak bilinen sanat dalının temelini oluşturmaktadır. Geleneksel Türk Sanatı tarihinin önde gelen dallarından biri olan halı sanatı, Kuzey Batı Anadolu’nun Çanakkale ili Ayvacık ilçesinde görülenlere benzer zengin motif, renk, kompozisyon özelliklerine sahip kirkitli dokuma örnekleri ile Orta Asya’dan günümüze kadar varlığını sürdürmüştür. Kökeni Kafkaslara dayanan Ayvacık halılarında geometrik, bitkisel ve hayvansal motifler kullanılmıştır. Bu motifler günümüzde sembolik anlam ve isimlerini yitirerek dokumacılar tarafından güncel nesnelere benzetilerek isimlendirilmektedir. Altın Tabak, Baratlı, Çakmaklı, Çarklı Elek, Kilim Desenli, Turnalı, Ayvacık halılarına isimlerini veren zemin kompozisyonlarıdır. Zengin bir miras olarak günümüze aktarılmış olan söz konusu motifler, çağdaş halı desenlerinde kullanıldığı gibi, çağdaş seramik formlarında da kullanılmaktadır. Bu bağlamda halı ve seramik sanatlarının harmanlandığı literatür çalışmaları incelenerek; Ayvacık halı motifleri ve özgün seramik tekniklerinin birlikte kullanıldığı multiıdisipliner bir çalışma yapılması hedeflenmiştir.
Yaratım Sürecinde İstisnai Çözümler ve Mutlu Kaza
Authors: Demir Sekan
Published: December 2022

Sınırsız sayıda olasılığın beklenmedik bir zamanda yan yana gelmesi gerçeğine dayanan rastlantı olgusu hem sanatın hem de gündelik hayatın temas noktalarından biridir. Bu yanı ile rastlantının evrende sürekli gezindiği ve olaylara belli durumlarda temas ettiği söylenebilir. Bu makalede yirminci yüzyıl başlarından itibaren sanatta sıklıkla karşılaşılan rastlantı ve serendip, (mutlu kaza) kavramlarına odaklanılmaktadır. Araştırmada ele alınan kavramların yaratım sürecinde gerçekleşme biçimleri, etki alanları ve yarattığı dönüşümler hem bilimsel hem de sanatsal örnekler eşliğinde irdelenmeye çalışılmıştır.
The design of a rural house in Bushbuckridge, South Africa: An Open Building interpretation
Authors: Hendrikz Wihan , Osman Amira
Published: December 2022

This qualitative study argues that occupant involvement in housing design and construction process should lead to more appropriate buildings that can sustain their usefulness with minimal changes. It documents the design of a house in Bushbuckridge, Mpumalanga, South Africa that uses Open Building (OB) principles so that the house adapts to the changing needs of the family and maintains its intergenerational value.
This project centres the occupant in the design and construction process and considers the house flexible and conceived by many authors. Based on this worldview, we use the following tools: a literature review on OB, an OB analysis of low-cost housing, and analysis of the design project.
We compare low-cost housing projects using four OB principles: how the project involves the occupant’s agency to build; how the project separates its elements to facilitate this agency; whether the project focuses on providing a housing product, or a housing process; and, how sustainably the delivered structure can accommodate the occupant’s current and future construction.
The paper illustrates these OB principles in the design of a low-cost, rural house project in Bushbuckridge to show that they also have value for the architecture at a small scale, and how a house can be designed to ensure that it adapts to the changing needs and creativity of the occupant.
The paper concludes with the implications that OB principles have for the design process. The process no longer consists of a simple sequence that separated design and construction and ends with a housing product. Rather, the design and construction focus on delivering a building process that the occupant can take ownership of a sustain intergenerationally.
Neighborhood Impact Assessment an urban sustainability instrument
Authors: Abreu Emanoele , Peres Renata
Published: December 2022

The Neighborhood Impact Assessment (NIA) [1]is an important instrument of the Brazilian Urban Policy enacted in the City Statute, Federal Law 10.257/2001. Considered by the national academic literature as a relevant instrument for local urban environmental management. However, in Brazil, the understanding that the environmental and the urban are part of the same context is not yet a reality within the local public administration sectors, with a deep disconnection of management and governance between the urban and environmental departments. The objective of this work was to analyze the application of NIA in medium-sized cities in the state of São Paulo and to evaluate its contribution to the local urban environmental management of these cities. We also intend to evaluate the NIA integration with other sectors of local public management such as the environment, urban mobility, social housing, etc. As a methodology, we used NIA Process Components, verifying the absence or presence in the urban laws of four (04) medium-sized cities in the state of São Paulo. We also interviewed civil servants from the environmental and urban sectors, supplementing information that was absent in laws and official documents. The results reveal that most municipalities do not have a specific law that regulates the NIA, and Master Plans, Land Use and Occupation Law regulate this instrument. Civil servants emphasize the weaknesses and strengths of the instruments. As potentialities of this instrument, they observed public participation, increased state control in environmentally sensitive areas, greater urban-environmental compensation mechanisms, and so on. Weaknesses signalize were: conflicts involving urban land subdivision, interference of the real estate market in the use and occupation of urban land, changes in the Master Plans by the city councilman aiming to meet the interests of private financial capital. The four cities, which are part of the Case Studies, have not yet effectively incorporated elements of climate change in their local governance. Issues related to social housing, expansion of slums, occupation of protected environmental areas by poor populations are still the most urgent priorities in these cities, as well as in many Latin American cities. The improvement and advancement of the articulation of the urban and environmental sectors in Brazilian cities must require thinking about better scientific methodological and governmental improvements.
 
[1] Brazilian authors often use the terminology in English “Neighborhood Impact Study”. However, we chose to use “Neighborhood Impact Assessment” according to (Abiko & Barreiros, 2014) to facilitate the understanding of the instrument for the international audience, as it has similarities with the Impact Assessment. However, in Brazil, the NIA is known as the “Estudo de Impacto de Vizinhança”.
The Role of Flavanones as Scaffolds for the Development of New Treatments
against Malaria and African and American Trypanosomiases
Authors: Boniface Pone Kamdem , Ferreira Elizabeth Igne , Fabrice Fekam Boyom
Published: December 2022

Parasitic infections are diseases transmitted by parasites usually found in contaminated
food, water, or insect bites. Generally classified as neglected tropical diseases, malaria and trypanosomiases
are some of the most prominent parasitic diseases that cause significant loss of life annually.
In 2020, an estimated 241 million malaria cases were reported, with 627,000 deaths worldwide. An
estimated 6 to 7 million people are infected with Trypanosoma cruzi worldwide, whereas an estimated
1000 global cases of African human trypanosomiasis were reported in 2020. Flavanones are a group of
compounds that belong to the flavonoid family and are chemically obtained by direct cyclization of chalcones.
Recent pharmacological studies have demonstrated the effectiveness of plant flavanones in inhibiting
the growth of the parasites responsible for malaria and trypanosomiases. The present work aims to
summarize up-to-date and comprehensive literature information on plant flavanones with antimalarial
and antitrypanosomal activities. The mechanisms of action of the antiparasitic flavanones are also discussed.
A literature search was performed for naturally occurring flavanones and antimalarial and antitrypanosomal
activities by referencing textbooks and scientific databases (SciFinder, Wiley, American
Chemical Society, Science Direct, National Library of Medicine, Scientific Electronic Library
Online, Web of Science, etc.) from their inception until April 2022. Based on in vitro experiments,
more than sixty flavanones were reported to exhibit antimalarial, anti-T. cruzi, and anti-T. brucei activities.
Previous studies demonstrated that these compounds bind to PGP-like transporters of P. falciparum
to reverse the parasite’s resistance. Other reports pinpointed the direct effect of these compounds
on the mitochondria of the malaria parasite. Moreover, flavanones have shown strong docking
to several validated T. cruzi and T. brucei protein targets, including adenosine kinase, pteridine reductase
1, dihydrofolate reductase, and trypanothione reductase, among others. Flavanones, isolated and
characterized from diverse plant parts, were reported to exhibit moderate to high activity against P.
falciparum, T. cruzi, and T. brucei in in vitro studies. These potentially active flavanones can be used
as scaffolds for the development of new antiparasitic agents. However, more studies on the cytotoxicity,
pharmacokinetics, and mechanisms of action of potent flavanones should be performed.
Antiseizure Medications for the Prophylaxis of Migraine during the Anti- CGRP Drugs Era
Authors: Rollo Eleonora , Romozzi Marina , Vollono Catello , Calabresi Paolo , Geppetti Pierangelo , Iannone Luigi F.
Published: December 2022

Migraine and epilepsy are fundamentally distinct disorders that can frequently coexist in the same patient. These two conditions significantly differ in diagnosis and therapy but share some widely- used preventive treatments. Antiseizure medications (ASMs) are the mainstay of therapy for epilepsy, and about thirty different ASMs are available to date. ASMs are widely prescribed for other neurological and non-neurological conditions, including migraine. However, only topiramate and valproic acid/valproate currently have an indication for migraine prophylaxis supported by high-quality evidence. Although without specifically approved indications and with a low level of evidence or recommendation, several other ASMs are used for migraine prophylaxis. Understanding ASM antimigraine mechanisms, including their ability to affect the pro-migraine calcitonin gene-related peptide (CGRP) signaling pathway and other pathways, may be instrumental in identifying the specific targets of their antimigraine efficacy and may increase awareness of the neurobiological differences between epilepsy and migraine. Several new ASMs are under clinical testing or have been approved for epilepsy in recent years, providing novel potential drugs for migraine prevention to enrich the treatment armamentarium and drugs that inhibit the CGRP pathway.
Clinical Value of Circ-PNPT1 on Adverse Pregnancy Outcomes of Patients with Gestational Diabetes Mellitus
Authors: Wang Song , Lin Yixiong , Li Qing , Wang Zhijian
Published: December 2022

Objective:

Several circular RNAs are associated with important pathophysiological characteristics of gestational diabetes mellitus (GDM). This study intended to measure the expression of circ-PNPT1 in sera of GDM patients and to expound on its values on pregnancy outcomes.

Methods:

About 104 GDM patients and 71 healthy controls were recruited. The expression pattern of serum circ-PNPT1 was measured by reverse transcription-quantitative polymerase chain reaction. The diagnostic efficacy of circ-PNPT1 and fasting blood glucose (FBG) on GDM was evaluated by receiver operating characteristic (ROC) analysis. Parameters of glycolipid metabolism were determined using automatic biochemical analyzers. The correlation between circ-PNPT1 and glycolipid metabolism parameters was analyzed using Pearson analysis. GDM patients were divided into a high expression group and a low expression group based on the median value of circ-PNPT1 expression. Curves of adverse neonatal outcomes were drawn by Log Rank analysis.

Results:

GDM patients exhibited higher circ-PNPT1 expression than healthy controls. The area under the ROC curve of circ-PNPT1 diagnosing GDM was 0.9184 and the cut-off value was 1.435 (90.38% sensitivity, 85.92% specificity). Serum circ-PNPT1 expression was positively correlated with FBG, total cholesterol, and triglyceride in GDM patients. Neonates born to GDM patients with high circ-PNPT1 expression were prone to adverse outcomes.

Conclusion:

Circ-PNPT1 was highly-expressed in the sera of GDM patients. Circ-PNPT1 affected glycolipid metabolism and its expression had certain reference values on adverse pregnancy outcomes.
Antiviral Activities of Some Traditional Medicinal Plants of Sri Lanka
Authors: Bandara H.M.S.K.H. , Alakolanga A.G.A.W. , Amarasinghe N.R. , Adikaram N.K.B. , Jayasinghe L. , Fujimoto Y.
Published: December 2022

The aim of this article is to review the antiviral activity of plants traditionally used in indigenous
medicine in Sri Lanka, their therapeutic potential, chemistry, and botany. Viral infections
represent an increasing threat to humans worldwide. Conventional antiviral drugs are available
against respiratory viruses. Naturally occurring antiviral activity of medicinal plants was used for
centuries in the country’s rich traditional medicine system consisting of Ayurveda, Siddha, Unani,
and Deshiya Chikitsa. Traditional physicians cure diseases, including those that originate from viruses,
through herbal medicine. To complement this, about 1430 species representing 838 genera,
equivalent to 45% of the entire flowering plant community, are considered medicinal. The present
article attempts to review the essence of decades of discoveries on antiviral and related properties of
21 medicinal plants, Allium sativum L., Annona muricata L., Ardisia elliptica Thunb., Azadirachta
indica A. Juss., Caesalpinia pulcherrima (L.) Sw., Coriandrum sativum L., Coscinium fenestratum
(Gaertn.) Colebr., Hedyotis corymbosa (L.) Lam., Hemidesmus indicus (L.) R. Br., Justicia
adhatoda L., Ocimum tenuiflorum L., Phyllanthus embilica L., Phyllanthus debilis Klein ex Willd.,
Piper longum L., Piper nigrum L., Solanum xanthocarpum Schrad & Wendl., Terminalia bellirica
(Gaertn.) Roxb., Terminalia chebula Retz., Tinospora cordifolia (Wild) Miers., Vitex negundo L.,
Zingiber officinale Roscoe. Among the medicinal plants commonly used in Sri Lankan traditional
medicine, Justicia adhatoda showed stronger anti-influenza virus activity, inhibiting virus attachment
and replication, while Terminalia chebula consisting of chebulagic and chebulinic acids,
demonstrated direct antiviral activity against sexually transmitted herpes simplex virus-2 (HSV-2).
Perilaku Tidak Memilih Anggota Persatuan Istri Tentara (Persit) Pada Pilkada Kabupaten Malang Tahun 2020
Authors: Mutmainah Nofia , Sobari Wawan
Published: December 2022

Non-voting behavior in Indonesia has increased, including in the regional head elections in Malang Regency in 2020. At one of the polling stations (TPS) the number of non-voting voters reached 82% of the total final voter list. It is known that the voters registered at the TPS are the wives of TNI soldiers or Persit (Army Wives Association). Persit members still have the right to vote like other civilians, in contrast to the TNI who are not allowed to vote. This study aims to find out what is the cause of non-voting behavior among Persit members and whether the husband's position as TNI influences it. This research is a type of qualitative research using the case study method from Robert K Yin. Based on the concept of non-selective behavior put forward by Rusk and Regsadale (1993), there are four approaches to non-selective behavior namely: the demographic approach, the psychological approach, the structural approach and the rational approach. In this case, psychological factors were identified as dominant driving factors for non-choosing behavior. There is no interest in the political affairs of the government, because living in a dormitory there is an assumption that regional government issues do not provide significant benefits. So that there is no initiative to find out information about the elections that will take place, then there is ignorance about the candidates which leads to the decision not to vote. In addition, the status of the husband's capacity as a TNI is also another reason for the behavior of not choosing persit members. So there is a need for real efforts from the government, especially the general election commission to increase awareness of the importance of participation in elections, including through outreach and cooperation.
Menjamin Kebebasan Individu Pasca Pandemi: Trust Government Framework untuk Membangun Kepercayaan Publik
Authors: Azmi Aulia Izzah , Satria Putra
Published: December 2022

After the COVID-19 pandemic, the government experienced a new challenge, namely restoring public trust in the government due to the reduction of individual freedom of the community based on emergency crisis conditions. This study focuses on explaining (1) the dynamics of public trust in the government in the post-pandemic phase (2) the tendency of the government to take strategic steps on a top-down basis so that it threatens individual freedoms affected by applicable policies and regulations (3) frameworks that can be applied to build public trust so that collaboration between sectors in dealing with the after effects of the pandemi can be achieved. The research method used in this article is a Systematic Literature Review by collecting primary data sourced from accredited journal articles and media news sources. The results of this study reveal that civil liberty in an emergency is limited and this has an impact on the crisis of Indonesian people's confidence in the government and has logical consequences for public stability in responding to policies. At the end of the discussion, the researcher offers a framework to build public trust after the COVID-19 pandemic that is oriented towards citizen engagement.
Kemampuan Laju Transmisi Uap dan Biodegradasi Edible Straw Dari Pati Umbi (Ganyong, Garut, Kimpul) dan Gelatin Ikan
Authors:   Universitas Pembangunan Nasional Veteran Jawa Timur, Anggraini Linda , Rosida Dedin Finatsiyatull ,   Universitas Pembangunan Nasional Veteran Jawa Timur, Wicaksono Luqman Agung ,   Universitas Pembangunan Nasional Veteran Jawa Timur Indonesia
Published: December 2022

Indonesia tergolong negara beriklim tropis yang memiliki keunggulan dalam keragaman sumber pati yang berasal dari umbi-umbian. Sedotan edible dari pati umbi-umbian ini dapat menjadi salah satu solusi alternatif mengatasi permasalahan degradasi sedotan, pengembangan produk dari komoditas umbi-umbian, dan dapat menambah nilai ekonomi masyarakat. Penelitian ini bertujuan untuk mengetahui pengaruh jenis pati umbi (ganyong, garut, kimpul) dan konsentrasi gelatin ikan terhadap karakteristik edible straw. Penelitian ini menggunakan metode Rancangan Acak Lengkap-Faktorial. Variasi perlakuan dari dua faktor yaitu jenis pati umbi (U), jenis pati umbi yang digunakan adalah pati ganyong, pati garut, pati kimpul, dengan masing-masing konsentrasi sebesar 4% (b/v) dan konsentrasi gelatin ikan (G) sebesar 1, 3, dan 5% (b/v). Perlakuan terbaik dari hasil analisis diperoleh pada formulasi jenis pati umbi garut 4% dengan konsentrasi gelatin ikan 5%. nilai rata-rata kadar air 11.02%, ketahanan terhadap air 56.85%, laju transmisi uap air 0.09 g/m2.jam, dan biodegradasi 93.74%.
Pengaruh Inokulasi Rhizobium dan Pupuk Anorganik NPK Terhadap Pertumbuhan Dan Hasil Tanaman Kedelai (Glycine max (L.) Merril)
Authors: dina annisa , Koesriharti Koesriharti Koesriharti
Published: December 2022

Kedelai merupakan sumber protein nabati bagi masyarakat. Produksi tanaman kedelai di Indonesia mengalami penurunan. Kebutuhan unsur N diperlukan dalam membantu penyerapan. Rhizobium sebagai bakteri penyedia hara bagi tanaman kedelai. Rhizobium dan tanaman kedelai saling menguntungkan karena tanaman kedelai memberikan respon berupa bintil akar dan memperoleh hara N yang disediakan oleh bakteri Rhizobium. Penelitian bertujuan untuk mengetahui dan mempelajari pengaruh interaksi penambahan rhizobium dan pemberian pupuk anorganik NPK terhadap pertumbuhan dan hasil tanaman kedelai. Penelitian dilaksanakan pada bulan Oktober 2021 sampai Januari 2022 di lahan petani yang berada di Desa Ampeldento, Karangploso, Kabupaten Malang, Jawa Timur, Indonesia. Percobaan menggunakan rancangan acak kelompok (RAK) faktorial terdiri dari dua faktor yakni, Faktor pertama : Tanpa Rhizobium dan Rhizobium 10 g.kg-1. Faktor kedua Pupuk NPK : 100, 150, 200, 250, and 300 kg.ha-1. Dilanjutkan dengan uji beda nyata terkecil (BNT) pada taraf 5%. Hasil penelitian terdapat interaksi pada variabel, yaitu luas daun (35 dan 42 hst), jumlah bintil akar, bobot biji per tanaman dan bobot biji per hektar. Pada perlakuan tanpa rhizobium dengan pupuk NPK 250 kg.ha-1 lebih baik dibandingkan perlakuan NPK 100 dan 150 kg.ha-1. Pada perlakuan rhizobium 10 g.kg-1 dengan pupuk NPK 200, 250, dan 300 kg.ha-1 lebih baik dibandingkan pupuk NPK 100 dan 150 kg.ha-1. Inokulan rhizobium 10 g.kg-1 dapat meningkatkan tinggi tanaman, jumlah daun, jumlah polong per tanaman, dan bobot 100 biji dibandingkan tanpa rhizobium, sedangkan pada pemberian pupuk NPK 250 dan 300 kg.ha-1 dapat meningkatkan tinggi tanaman, jumlah daun, luas daun, jumlah polong per tanaman, dan bobot 100 biji.
Pengaruh Pupuk Organik Cair dan PGPR (Plant Growth Promoting Rhizobacteria) Terhadap Pertumbuhan dan Hasil Marigold (Tagetes erecta L.)
Authors: Pangidung Nurfianto Giar , Nihayati Ellis
Published: December 2022

Marigold (Tagetes erecta L.) merupakan salah satu komoditas tanaman hias bunga potong untuk upacara keagamaan yang memiliki nilai jual yang tinggi serta sebagai tanaman perangkap hama. Budidaya marigold yang secara intensif dengan input pupuk anorganik dan ketergantungan petani akan itu menyebabkan kesuburan tanah menurun. Salah satu solusi yang digunakan yaitu dengan aplikasi pupuk organik cair dan PGPR. Dalam aplikasinya dibutuhkan dosis dan cara aplikasi pupuk organik cair dan PGPR yang tepat agar hasil tanaman yang didapat lebih optimal. Penelitian ini bertujuan untuk mendapatkan taraf tertentu POC yang memerlukan taraf tertentu PGPR agar pertumbuhan dan hasil marigold menjadi optimal. Penelitian dilaksanakan pada lahan pekarangan di Perum. Griya Permata Alam FD-11, Desa Ngijo, Kec. Karangploso, Kab. Malang pada ketinggian 515 mdpl dan suhu rata-rata 23-25°C. Waktu pelaksanaan penelitian dimulai dari April 2021-Juli 2021. Penelitian menggunakan desain rancangan petak terbagi dengan 3 taraf petak utama yaitu L0 (kontrol), L1 (Konsentrasi POC 5 ml/l), dan L2 (Konsentrasi POC 10 ml/l) serta 3 taraf anak petak yakni P0 (kontrol), P1 (Konsentrasi PGPR 10 ml/tanaman), dan P2 (Konsentrasi PGPR 20 ml/tanaman) yang diulang 4 kali. Hasil penelitian menunjukkan terdapat interaksi nyata antara perlakuan POC dan PGPR dengan luas daun dimana setiap penambahan konsentrasi POC 10 ml/l membutuhkan dosis PGPR 20 ml untuk mendapatkan luas daun marigold terluas. Kedua perlakuan tidak menunjukkan pengaruh nyata pada tinggi tanaman, jumlah bunga, diameter bunga, warna bunga, bobot segar tanaman, dan vase life bunga marigold sehingga aplikasi POC dan PGPR tidak direkomendasikan untuk tanaman marigold.
Identifying family caregivers as preventive medicine: An essential component of comprehensive primary care
Authors: Baumblatt Geri Lynn , Applebaum Allison J
Published: December 2022

Many patients are also family caregivers, who care for an ill or disabled family member or friend. Most do not “self-identify” as caregivers. Over time, caregiving can have significant effects on caregivers, as they often put their own health last. Primary care is an ideal place to identify caregivers through screening for caregiving status as part of patient history. This practice allows for the triaging of caregivers to appropriate supports and services, and as such is a form of preventive medicine.
The Landscape of Single Nucleotide Polymorphisms in Papillary Thyroid Carcinoma
Authors: KYRODIMOS EFTHYMIOS , CHRYSOVERGIS ARISTEIDIS , MASTRONIKOLIS NICHOLAS , PAPANASTASIOU GEORGE , TSIAMBAS EVANGELOS , SPYROPOULOU DESPOINA , KATSINIS SPYROS , MANOLI AREZINA , PAPOULIAKOS SOTIRIOS , PANTOS PAVLOS , RAGOS VASILEIOS , PESCHOS DIMITRIOS , PAPANIKOLAOU VASILEIOS
Published: December 2022

Thyroid carcinoma represents a leading malignancy among those derived from human endocrine systems. It comprises a variety of different histological subtypes, including mainly papillary carcinoma, follicular carcinoma, anaplastic carcinoma, and medullar carcinoma. A broad spectrum of genetic imbalances, comprising gross chromosomal (polysomy/aneuploidy) and specific gene (mutations, amplifications, deletions) alterations, has been reported. Interestingly, the role of isolated, specific gene polymorphisms, especially of the single nucleotide polymorphism (SNP) type, in thyroid carcinoma is under investigation. SNPs are the most common genetic variations in the genome. The current molecular review focuses on the impact of specific SNPs on the biological behavior of papillary thyroid carcinoma in their carriers.
Neutrophil-to-Lymphocyte Ratio Is a Major Prognostic Factor in Non-small Cell Lung Carcinoma Patients Undergoing First Line Immunotherapy With Pembrolizumab
Authors: ROMANO FRANCESCO JACOPO , RONGA RICCARDO , AMBROSIO FRANCESCA , ARUNDINE DARIO , LONGO VITO , GALETTA DOMENICO , GRIDELLI CESARE , MAIONE PAOLO , PALMA VALENTINA , DAMIANO VINCENZO , VERDE ANTONIO , GIACOBBE ILARIA , AUGURIO MARIA ROSARIA , IENGO GENNARO , CHETTA MASSIMILIANO , TARSITANO MARINA , CAMPIONE SEVERO , FAILLA GIUSEPPE , RAUCCI ANTONIO , RICCARDI FERDINANDO
Published: December 2022

Background/Aim: Lung cancer is one of the most common malignant neoplastic diseases and by far the leading cause of cancer death worldwide. Recently, immune checkpoint inhibitors (ICIs) have received increasing attention for playing a crucial role in non-small cell lung cancer (NSCLC). Biomarkers, such as programmed cell death-ligand 1 (PD-L1) and tumor mutational burden (TMB), seemed to be helpful in selecting patients who are more likely to benefit from ICI treatment: however, their role has not yet been fully clarified. Patients and Methods: In this retrospective study, we evaluated the relationship between pre-treatment peripheral blood neutrophil-to-lymphocyte ratio (NLR) and survival in 252 patients suffering from advanced NSCLC who had received pembrolizumab as their first-line immunotherapy. Results: Compared to their NLR low counterparts who had a median overall survival (OS) of 34.8 months, patients with NLRs above 4.8 had a median OS of 7.6 months (HR=3.26, 95%Cl=2.3-4.6, p-value<0.0000001). In multivariate Cox regression analysis, alongside other variables, such as metastatic sites, age, and sex, NLR and PD-L1 predicted progression-free survival and OS; furthermore, a very high NLR – over 10 – seemed to forecast a very dismal prognosis in patients undergoing immunotherapy, with sudden deaths in the days immediately following therapy (median OS=3.8 months). Conclusion: NLR acts as a valuable and reliable prognostic factor in non-small cell lung carcinoma patients undergoing first line immunotherapy with pembrolizumab. Additional investigation is necessary to fully elucidate the underlying biological rationale, which can be found in myeloid derived suppressor cells, a heterogeneous population of cells with neutrophil-like immunophenotypic features.
SERİ BAĞLI U-BORULU VAKUM TÜPLÜ GÜNEŞ KOLEKTÖRÜNÜN ISIL VERİMİ VE BASINÇ DÜŞÜMÜNÜN DENEYSEL İNCELENMESİ
Authors: ÖZCAN İsmail , ÖZGÜR Arif Emre , ÖZSOY Ahmet
Published: December 2022

Günümüzdeki çevresel sorunların en başında küresel ısınma gelmektedir. Bu sorunun çözümünün temiz enerji kaynaklarından geçtiği genel bir kanıdır. Güneş enerjisi de bu temiz enerji kaynaklarından olup, günümüzde elektrik enerjisi üretimi, sıcak su hazırlama, kurutma ve birçok endüstriyel uygulamada kullanılmaktadır. Bununla birlikte, elektrik üretiminde yaygın olarak kullanılan fotovoltaik sistemlerin verimleri nispeten düşüktür. Düzlemsel toplayıcılar ile elde edilecek akışkan sıcaklığında ise bir sınır vardır. Kurutma uygulamalarının da havalı düzlemsel toplayıcılar ile yapılması, birim kuru ürün için gerekli toplayıcı alanını arttırmaktadır. Dolayısıyla, güneş enerjisinin bu üç ana alanda, daha yüksek verim ile değerlendirilebileceği araştırma geliştirme çalışmaları sürmektedir. Bu çalışmada vakum tüplü, seri bağlı U-borulu bir güneş kolektörü iç ortamda test edilerek verim eğrileri oluşturulmuştur. Çalışmada literatürdeki çoğu çalışmada kullanılan vakum tüplerden farklı olarak dış çapı 70 mm olan 10 adet vakum tüp ve bunların içine yerleştirilen 8 mm dış çaplı, U forma getirilmiş, seri bağlı çelik borular kullanılmıştır. Sirkülasyon pompası ve sisteme entegre edilmiş bir plakalı ısı değiştirici ile kapalı bir çevrim oluşturularak, güneş simülatörü ile iç ortam şartlarında ölçümler gerçekleştirilmiştir. Simülatörden güneş kolektörü üzerine ortalama 902 W/m2 ışınım şiddeti halojen lambalarla sağlanmıştır. Deneyler, U-borular içindeki akışkan debisi için 3 farklı değerde ve 4 farklı giriş sıcaklığı ile gerçekleştirilmiştir. Yapılan deneysel çalışmada kolektör veriminin %60 ile %78 arasında değiştiği görülmüştür. U-borulu güneş kolektörünün giriş-çıkış arası basınç düşümü 59-65 kPa arasında değişmektedir. Elde edilen analiz sonuçlarına bakıldığında, büyük çaplı vakum tüpe sahip ve seri bağlanmış çelik borulu toplayıcı kullanımının, kolektör çıkış sıcaklığında artış sağlamakla birlikte basınç düşümü de yüksek olduğundan, sistem seçiminde pompalama gücünün de dikkate alınması gerekmektedir.
KÖPÜK DOLGULU HAFİFLETİLMİŞ DONATILI ZEMİN PANELLERİNİN DAVRANIŞI
Authors: EVİRGEN Burak , TUNABOYU Onur , BÜYÜK Barış , ÇİL Gizem Tuğçe
Published: December 2022

Eğimli veya dik arazilerdeki yanal toprak basıncı ve yüzey duraylılığı gibi etkilere karşı kullanılan ağır prekast betonarme paneller hem şantiyeye iletim hem de yerleştirme sırasında ciddi sorunlara neden olmaktadır. Üretim aşamasında daha hafif elemanların kullanılması arazideki montaj kolaylığına ek olarak işçilik gereksinimini azaltmakta ve uygulama hızını arttırmaktadır. Bu sebeple çalışma kapsamında, gerçek boyutlu donatılı beton numuneler ve genişletilmiş polistren köpük (EPS) elemanlar yardımıyla boşluklu kesitlerle üretilen hafif numunelerin deneysel davranışı incelenmiştir. Özel olarak tasarlanan deneysel düzeneklerde söz konusu numuneler üzerinde düzlem içi diyagonal kesme testleri (panel testleri) ve üç noktalı eğilme testleri gerçekleştirildikten sonra yük - deplasman değişimleri sunulmuştur. Çelik donatılı numunelere kıyasla yaklaşık %13 mertebesinde daha hafif olan EPS köpüklü numuneler eğilme testlerinde benzer davranış sergilerken, panel testlerinde farklı göçme durumları ön plana çıkmaktadır. Alternatif hafif kompozit panellerin kullanılmasıyla konvansiyonel donatılı beton panellerin toplam maliyetinin düşürülebileceği açıkça görülmektedir. Çalışma sonucunda mekanik stabilize donatılı duvarlarda ve donatılı zeminlerde kullanılan konvansiyonel kaplama elemanlarına alternatif özgün bir ürün önerilmiştir.
ELEKTRİKLİ ARAÇ ENTEGRASYONUNUN DAĞITIM SİSTEMİNE ETKİLERİNİN İNCELENMESİ VE ŞARJ İSTASYONU ALTYAPISININ TAYİN EDİLMESİ
Authors: YILDIZHAN Dilan , ERENOĞLU Ayşe Kübra , ERDİNÇ Ozan
Published: December 2022

Günümüzde hızla artan nüfusun paralelinde yaşamsal ihtiyaçlara bağlı tüketimler için ortaya çıkan teknolojik gelişmeler ve sanayileşme ile enerji ihtiyacı her geçen gün artmaktadır. İlgili enerji ihtiyacı daha çok konvansiyonel kaynaklardan karşılanmakta ancak bu durum çevre kirliliğine sebebiyet vermektedir. Fosil yakıtların en çok tüketildiği ve doğal olarak karbon emisyonuna neden olan alanlardan biri olan ulaşım sektöründe ise ciddi değişimler meydana gelmektedir. Özellikle fosil kaynaklı araçlar yerini Elektrikli Araçlara (EA) bırakmakta ve birçok marka EA modelleri geliştirmeye yönelik önemli adımlar atmaktadır. Ancak EA’ların üretim ve kullanımının artması enerjiye olan ihtiyacı da katlamaktadır. Aynı zamanda bu araçların şarj ihtiyaçları için kurulması gereken şarj istasyonu sayısı ve yatırım gerektiren altyapı hizmetlerinin planlanmasını zorunlu kılmaktadır. Bu çalışmada, Türkiye’de hizmet veren bir dağıtım sistemi operatörlüğünde işletilen ve EA şarj istasyonu kurulması planlanan otopark alanları için DIgSILENT PowerFactory V15.1 programında detaylı analizler gerçekleştirilmiştir. Türkiye’de hizmet veren bir otopark işletmecisi ile ortak çalışılacak alanlarda altyapı hizmetlerinin aksamaması ve olası güç sistemi arızalarının önüne geçebilmek amacıyla güç akışı analiz sonuçları paylaşılmıştır. Hatlardan akan aktif, reaktif güçler ve transformatör yüklenmelerine göre öneriler sunulmuştur.
Electronic Medical Record System Use During Mass Casualty Incidents (Preprint)
Authors: Hitti Eveline , Hadid Dima , Saliba Miriam , Sadek Zouhair , Jabbour Rima , Antoun Rula , El Sayed Mazen
Published: December 2022

BACKGROUND

Emergency Departments (EDs) play a central role in defining the effectiveness and quality of the overall hospital’s Mass Casualty Incident (MCI) response. The use of Electronic Medical Records (EMR) in hospital settings has been rapidly growing globally. There is however a paucity of literature on the use and performance of EMR during MCIs.

OBJECTIVE

This study aims to describe EMR use, as well as the challenges and lessons learnt in response to the Beirut Port Blast, one of the largest non-nuclear explosions.

METHODS

Event setting, pre-existing emergency preparedness plan and use of EMR during an MCI at one of the largest academic tertiary care centers in Beirut, Lebanon were described. General response principles were observed, feedback was collected, and proposed modifications were summarized to help inform readers about EMR challenges and modifications required for MCI response plans.

RESULTS

Different aspects of EMR utilization during MCIs were described. IT support, reducing EMR system restrictions, cross function training, focus on registration and patient identification, patient flow and tracking, mobility and bedside access, alternate sites of care are all important areas to assess during emergency /disaster response planning.

CONCLUSIONS

Use of EMRs during MCIs can be challenging. Modifications to different elements of the disaster response plan are usually needed and innovative solutions can help improve response and reduce barriers to EMR use during MCIs.
Child and Adolescent Mental Health Service responsiveness to the Needs of Ethnic Minority Communities in England: A Systematic Review. (Preprint)
Authors: Isiwele Anthony
Published: December 2022

BACKGROUND

In 2018, the Care Quality Commission, an independent body of the Department of Health and Social Care, published its findings from a review in England CAMHS (Child and Adolescent Mental Health Service). They found that CAMHS are still not responsive to the specific needs of ethnic minorities children and young people. This might have elicited various interventions, including revamping IAPT (Improving Access to Psychological Therapies) for ethnic minorities. Yet, a 2022 published report by the NHS Race and Health Observatory body, which examines health inequalities experienced by minoritized groups in England, unequivocally revealed that ethnic minority people's fear and distrust of mental health services form clear barriers to seeking help.

OBJECTIVE

To review CAMHS’ responsiveness to the specific needs of ethnic minority children and young people in England.

METHODS

The precepts of systematic review were used to locate, appraise and synthesize relevant studies across four central electronic databases, including snowballing approach. A total of 10 studies published between 2013 and 2020 met the inclusion criteria and were reviewed in this study.

RESULTS

The included studies have substantial England coverage, Northwest England (3), South England, precisely at Greater London (n = 3), East England (n = 2), and West England (n = 1), with national spread (n = 2). Thus, six analytical themes emerged: CAMHs are responding with services that are hardly accessible; Culturally inappropriate; Direct response; The role of religion; Voluntary and statutory setting; and Institutional defence and racism.

CONCLUSIONS

CAMHS needs to respond by closing the inequality gap in mental healthcare delivery for ethnic minority children and young people. It would be by ensuring CAMHS is accessible and promoting a functional intersectoral approach between the statutory and voluntary sectors within the local community. In addition, improve the capacity to disseminate targeted and relevant information to ethnic minorities with a culturally sensitive CAMHS devoid of racial aggression.
Pendefinisian Jaring Kontrol Sistem Cerdas Candi Borobudur ke dalam Datum SRGI 2013
Authors: Christy Nerissa Mutiara , Ma'ruf Bilal , Atunggal Dedi
Published: December 2022

Candi Borobudur merupakan candi Buddha terbesar di dunia dan diakui sebagai salah satu warisan budaya yang dilindungi oleh United Nations Educational, Scientific and Cultural Organization (UNESCO). Sebagai salah satu realisasi pemeliharaan Candi Borobudur dilakukan pemantauan stabilitas Candi Borobudur melalui pengukuran yang dilakukan secara periodik setiap tahun sejak 1983. Seiring dengan kemajuan teknologi, pemantauan stabilitias candi dapat dilakukan dengan menggunakan system cerdas. Untuk itu diperkenalkan Sistem Cerdas Candi Borobudur. Sistem Cerdas Candi Borobudur menggunakan Robotic Total Station (RTS) untuk pemantauan deformasi secara real-time. Untuk mendukung pemantauan stabilitas candi menggunakan (RTS) perlu dilakukan pendefinisian jaring kontrol pemantauan sistem cerdas ke dalam datum Sistem Referensi Geospasial Indonesia (SRGI) 2013. Pada penelitian ini dilakukan pendefinisian jaring kontrol pemantauan yang berada di halaman Candi Borobudur ke dalam datum SRGI 2013. Pendefinisian dilakukan dengan pengamatan Global Navigation Satellite System (GNSS) metode statik pada 7 November 2019 date of year (doy) 311 selama ± 6 jam dengan sampling-rate 30 detik dan mask angle 15°. Pengolahan data pengamatan GNSS dilakukan dengan menggunakan software Spectra Precision GeoGenius dan 4 titik Continuously Operating Reference System (CORS) Badan Informasi Geospasial (BIG) CKBM, CMGL, JOGS, dan CSLO sebagai titik ikat. Analisis penentuan kelas dan orde mengacu Standar Nasional Indonesia Jaring Kontrol Horizontal (SNI JKH). Hasil dari penelitian yang telah dilakukan berupa 9 titik jaring kontrol pemantauan sistem cerdas yang telah terdefinisi dengan baik terhadap 4 titik CORS BIG dengan ketelitian berkisar dari 4 mm s.d. 13 mm. Penentuan kelas yang dilakukan menggunakan hasil perataan jaring bebas dengan 1 titik ikat. Orde dari jaring ditentukan dari hasil perataan jaring terikat dengan 4 titik kontrol yang terdistribusi pada 4 kuadran. Hasil dari analisis menunjukkan bahwa jarring dikualifikasi sebagai kelas 2A dan orde 1. Pemantauan sistem cerdas menggunkan RTS sudah dapat dilakukan dengan mengacu pada koordinat titik-titik jaring pemantauan yang sudah diperoleh.