bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of Laboratory Diagnostics on Nursing Management of Respiratory Tract Infections: Review of Current Technologies and Their Implications for Patient Care
Authors: Alsharari Mohammed Madallah S , Alsharari Mohammed Atallah Hayshan , Alsharari Ghazi Salman Saleem , Alruwaili Ibtisam Ibrahim Rahil , Alsharari Ahmed Aqeel Mufadhi , Alshrari Nader Sliman F , Maashi Afrah Nasser Mosa , Mutee Hind Gassem Habib , Alsharari Muteb Mutlaq Ghafil , Alsharari Ibrahim Sabih Basheer
Published: January 2025

Background: Respiratory tract infections (RTIs) represent a significant public health challenge due to their high prevalence and associated morbidity and mortality rates. Accurate and timely laboratory diagnostics are crucial for effective nursing management of these infections, ensuring appropriate treatment and minimizing the misuse of antimicrobials. Methods: This review synthesizes current literature on laboratory diagnostic technologies for RTIs, emphasizing the role of syndromic panels and molecular techniques in detecting bacterial and viral pathogens. It discusses the epidemiological trends of RTIs, diagnostic methodologies, and the implications for nursing management in clinical settings. Results: Recent advancements in diagnostic technology, particularly molecular methods, have enhanced the accuracy and speed of identifying RTIs, which is essential for effective patient management. Syndromic panels allow for the simultaneous detection of multiple pathogens, facilitating rapid clinical decision-making. However, challenges remain, including the cost of molecular assays and the need for appropriate specimen collection and handling to ensure diagnostic reliability. Conclusion: The integration of advanced laboratory diagnostics into nursing practice is vital for improving outcomes in patients with RTIs. Nurses play a critical role in the diagnostic process, from specimen collection to interpreting results, which informs treatment decisions. Ongoing education and training are necessary to equip nursing professionals with the skills needed to utilize these advancements effectively.
A 32-Year Analysis of Occupational Safety and Health in Ecuador: Regulatory Impact on Workplace Morbidity and Mortality
Authors: Gómez-García Antonio Ramón, , Chica Mayra Liuviana, Vega , Yturralde Mg. Juan Gabriel,
Published: January 2025

Background: This study analyzed the evolution of work-related injuries and fatalities in the Republic of Ecuador from 1990 to 2022 using a time-series trend analysis, with the secondary objective of assessing the impact of public policies. Methods: The data were obtained from the administrative records of the Ecuadorian Social Security Institute and categorized into six periods based on the introduction of legal frameworks regulating social security. Epidemiological indicators, including morbidity, mortality, and lethality rates, were calculated using the working population insured and protected by General Insurance for Occupational Risk. Results: The results showed that between 1990 and 2022, 269,969 work-related injuries were classified, of which 2% were fatal (5,352 deaths). The overall morbidity rate remained stable, whereas the overall mortality and case fatality rates exhibited significant declining trends. Conclusion: Trend variations and significant differences between periods were observed for each indicator. Despite efforts to improve OSH in Ecuador, the lack of a consistent downward trend highlights the regulatory framework’s limited effectiveness. The findings suggest the need for a more in-depth analysis to explain the factors underlying the differential effects between periods and the establishment of a robust national OSH policy aligned with ILO Conventions No. 155 and No. 187 to promote a proactive safety culture.
Implementasi Sistem Layanan Cuci Kendaraan Panggilan Berbasis Website pada Jasa Carenmore
Authors: Dina Dwi Arika  , Dinda Amalia Julyandri  , Fatkhur Rozak  , Lukman Lukman  , Sholihah Ayu Wulandari
Published: January 2025

The rapid development of information technology has provided great opportunities for the service sector to improve efficiency and convenience, including in vehicle washing services. This research aims to develop a web-based system using the Laravel framework, which is designed to simplify the online ordering process and overcome queuing problems. The system features user authentication, location-based booking, payment gateway integration for real-time transactions, and an interactive dashboard for service providers. The case study was conducted at Carenmore, a vehicle wash service in Krian. The implementation results show that the system is able to reduce customer waiting time, provide a better user experience, and improve service efficiency. Further development is recommended to add a variety of features, improve interface design, and increase the system's ability to handle larger user loads.
中国-巴基斯坦太空合作的现状及前景
Authors: HUANG Dekai
Published: January 2025

科技进步驱动下，国际合作边界已扩展至太空领域。中巴太空合作作为双边关系的新亮点，自1976 年起历经四个阶段发展，在“一带一路”框架及中巴经济走廊支撑下，正构建“天基丝绸之路”， 并步入加速发展期。合作动因根植于中国太空技术的快速崛起与巴基斯坦的太空需求，形成互补效应。尽管新冠疫情带来资金紧张与合作政治化等挑战，中巴太空合作仍展现出坚韧潜力与广阔未来。通过深化政策对话、技术交流与人才培养机制，双方正积极应对挑战，旨在推动合作向更高水平迈进。此合作范例不仅促进了两国互利共赢，也为全球太空合作提供了实践参考，彰显了国际合作在太空探索与人类共同发展中的核心价值。
Implementation of in vivo models to identify potential candidates for treatment of Dry Eye Disease
Authors:   , Compagnone Agnese
Published: January 2025

This thesis explores the development of an evaporative dry eye (EDE) animal model based on Meibomian gland cauterisation, aiming to replicate the tear film alteration caused by Meibomian gland dysfunction (MGD), a major driver of EDE. Dry eye disease (DED), which causes ocular surface inflammation, pain, and discomfort, is a multifactorial condition with significant impact on quality of life. EDE is the most common subtype, linked to MGD, which impairs lipid secretion from Meibomian glands, increasing the tear evaporation rate. The cauterisation method, as suggested by existing literature, faced challenges: technique variability and unclear guidelines on how many glands to cauterise or whether both eyelids should be involved. These inconsistencies can compromise the model’s reliability, indicating the need for further optimisation to ensure reproducibility and consistency in experimental outcomes. This thesis also presents a novel multiplex electrochemiluminescence immunoassay (ECLIA) for detecting key biomarkers in rat tear samples, critical for DED research. Biomarkers such as interleukin-17 (IL-17), matrix metalloproteinase-9 (MMP-9), and intercellular adhesion molecule-1 (ICAM-1) were targeted. The assay was validated with promising results, showing that the detection ranges for these biomarkers met the required parameters, though precision was identified as a limiting factor. Variations were mainly due to human error, such as pipetting inconsistencies and evaporation during incubation. Suggestions for improving precision include standardising operator expertise, minimising reagent variability, and controlling incubation conditions. These improvements would increase reliability and broaden the assay's detection range. Additionally, the thesis investigates the role of oxidative stress and ferroptosis in DED. Ferroptosis, a form of iron-dependent cell death linked to lipid peroxidation, is thought to contribute to DED pathogenesis. In vitro studies with the ferroptosis inhibitor UAMC-3203 suggested potential in reducing oxidative stress. However, clear evidence for ferroptosis in DED models was not found. In vivo tests showed that UAMC-3203 could restore GPX4 gene expression closer to the control group, hinting at potential benefits of ferroptosis inhibition. Finally, the thesis proposes optimising the EDE model with inflammation-triggering agents like LFA-1 and ICAM-1 inhibitors, or toll-like receptor agonists, to enhance chronicity and inflammation. The use of advanced 3D cell culture models for better simulation of the ocular surface is also discussed, highlighting their potential for testing new therapies. Further research is needed to address the multifactorial causes of DED and improve treatments for this widespread condition.
基于中美比较的中国数字服务贸易高质量发展路径研究Research on the Path to High-Quality Development of China's Digital Service Trade: A Comparative Perspective of China and the United States
Authors: 孟方琳  , 左婧楠  , 赵袁军  , 王德力  , 蒋君仙
Published: January 2025

在数字经济时代背景下，数字服务贸易迎来重大发展机遇。随着跨境服务贸易成本的有效降低和本土服务对国际需求的灵活适应，数字服务贸易的可交易度得到大幅提升。我国数字服务贸易近十年高速发展且硕果累累，但是与美国相比仍存在数字服务贸易进出口规模相对较小、结构失衡、限制性措施较多等问题。为推动我国数字服务贸易高质量发展目标，以美国作为比较对象，在规模、细分领域、限制性措施、国际竞争力四个方面对两国的数字服务贸易进行对比分析，研究发现，我国数字贸易在整体体量、细分领域、限制性措施和国际竞争力上弱于美国。因此从加大数字服务贸易投入力度，积极营建良好营商环境；推动数字服务贸易对外开放水平，增强其国际影响力；打通数字贸易产业链，积极推进服务企业数字化转型，全面提升我国数字贸易国际竞争力等方面提出我国数字服务贸易高质量发展的路径。
In the era of the digital economy, digital service trade is experiencing significant development opportunities. The effective reduction of cross-border service trade costs and the flexible adaptation of local services to international demand have greatly enhanced the trade capacity of digital service trade. Over the past decade, China's digital service trade has developed rapidly and achieved notable progress. However, compared to the United States, several challenges remain, such as the relatively small scale of digital service trade imports and exports, structural imbalances, and more restrictive measures. To promote the high-quality development of China's digital service trade, this study takes the United States as a comparative benchmark. It examines and analyzes the two countries’ digital service trade from four key aspects: scale, market positioning, restrictive measures, and international competitiveness. The findings indicate that China lags behind the United States in overall trade capacity, market positioning, restrictive measures, and international competitiveness. Therefore, to achieve high-quality development in China’s digital service trade, efforts should focus on several key areas: increasing investment in digital service trade, actively fostering a favorable business environment, enhancing the openness of digital service trade to strengthen its international influence, expanding the digital trade industry chain, and promoting the digital transformation of service enterprises. These measures will comprehensively enhance the international competitiveness of China's digital service trade.
反思与突破：新世纪以来基督教在华医疗传教研究路径述评 Reflection and Breakthrough: A Review of Research on Christian Medical Missions in China Since the New Century
Authors: 廖鹏飞
Published: January 2025

基督教四度入华，医疗传教都曾发挥重要作用。在新世纪以来的基督教研究中，医疗传教研究主要集中于以城市为中心的医疗传教历史梳理、以基督教为主体的医疗传教原因分析、以地区为视域的医疗传教实践和影响研究等方面。基于既有研究，还需加强医疗传教跨地区的整体性研究、以信仰主体为中心的研究、医疗与传教关系研究以及借医传教的基督教中国化研究。Christianity has entered China four times, with medical missions playing a significant role each time. Since the beginning of the new century, research on Christian medical missions has primarily focused on the historical review of urban-centered medical missions, the analysis of the reasons for medical missions centered on Christianity, and the exploration of the practices and impacts of medical missions from regional perspectives. Building on existing research, further efforts are needed to strengthen cross-regional studies of medical missions, faith-centered research, studies on the relationship between medicine and mission, and investigations into the indigenization of Christianity in China through medical missions.
Freedom of Expression under Threat: the Need for Public Debate
Authors:   -, CASTELLANET Amélie , CASTELLANET Christian ,   -, KIBLER Jean-François ,   -, SCHICHT Jutta ,   -
Published: January 2025

Since 2020, the citizens' collective Les Citoyens en Alerte has been working to defend the freedoms threatened by the State of Health Emergency in France. During this crisis, it has observed increasing restrictions on freedom of speech, in a variety of forms, both legal and extra-legal. Following an overview of these restrictions, this article examines recent developments in French and European legislation on the subject. It then analyses the rapid development of legislation concerning digital media and the fight against fake news on the Internet. It concludes that, under the aegis of Europe, an unprecedented system of administrative censorship has been put in place, delegated to the major multinational operators GAFAM, which presents a serious threat to freedom of speech and the organisation of public discussion.
La necesidad de un cambio tributario en materia de economía digital
Authors:   Universidad de Castilla-La Mancha, Álamo Cerrillo Raquel
Published: January 2025

El impacto económico y social de la economía digital tiene una repercusión no despreciable sobre los ingresos y gastos públicos, dando lugar a una disminución de los primeros como consecuencia de la facilidad de la deslocalización fiscal de empresas de carácter digital. Razón por la que hay que buscar nuevas alternativas de tributación en el marco de la economía digital, ante la ineficiencia de la aplicación de los sistemas tributarios tradicionales, donde ha quedado patente la no aplicación del principio de suficiencia tributaria. Por ello, en este trabajo se defiende la necesidad de realizar un exhaustivo análisis de la evolución legislativa de la tributación de la economía digital, en especial de las plataformas colaborativas, en busca de una fiscalidad adecuada al conjunto de la economía digital, que respete los principios básicos de tributación.
La geolocalización en Twitter como herramienta de análisis del impacto de la innovación en el País Vasco
Authors:   Universidad de Alicante, Núñez Romero María , Serrano Estrada Leticia ,   Universidad de Alicante
Published: January 2025

El objetivo del presente trabajo es evaluar el impacto de la innovación en un ámbito geográfico a partir de datos de redes sociales. Para la obtención de este fin, se desarrolla una estrategia de estudio en la que se enmarca el área geográfica correspondiente a la Comunidad Autónoma del País Vasco, región española con un sistema de innovación asentado, y de la cual se extraen datos geolocalizados de Twitter. Se analiza la presencia en los tuits de la palabra «innovación» y de otros términos relacionados. La geolocalización de tuits vinculados a la innovación en el País Vasco proporciona una visualización de los polos geográficos más innovadores que, contrastados con otras variables, ofrecen una visión de la magnitud económica de cada uno de los polos innovadores identificados.
Hacia el Mercado Único Digital en la Unión Europea: retos y potencialidades para los entes subestatales
Authors:   Universidad de Deusto, Pérez de las Heras Beatriz
Published: January 2025

El Mercado Único Digital (MUD) constituye actualmente una de las prioridades principales de la Unión Europea (UE). Las acciones adoptadas hasta el momento han sido importantes, pero la UE sigue retrasada con respecto a otros países en aspectos como el comercio electrónico. En este trabajo se argumenta este retraso debido, fundamentalmente, a la fragmentación normativa que caracteriza el mercado interior europeo en sectores no digitales. En términos de gobernanza, otra deficiencia en la implementación del MUD ha sido la escasa consideración al papel de las entidades subestatales. Consecuentemente, la realización plena del MUD pasa por acometer una armonización normativa profunda en sectores no digitales y por garantizar una participación más activa de los actores subestatales, para que los beneficios de la digitalización lleguen a todos los ciudadanos y comunidades.
Comercio electrónico y redes de producción global
Authors:   Universidad Complutense de Madrid, Álvarez Isabel , Marín Raquel ,   Universidad Complutense de Madrid
Published: January 2025

Este trabajo explora si la adopción de las tecnologías de la información y las comunicaciones (TIC) y, en particular, el comercio electrónico, tienen un efecto directo en la extensión y configuración de las redes de producción global, atendiendo a las decisiones de internacionalización e internalización de las empresas manufactureras españolas. Para realizar el análisis, se consideran las transacciones en el mercado final que tienen lugar a través del comercio electrónico, entre productor y consumidor B2C (business to customer), y también las transacciones intermedias entre empresas B2B (business to business). Los resultados confirman que el comercio electrónico B2C favorece en general la actividad internacional de las empresas españolas, El comercio electrónico B2B, por el contrario, promueve una mayor concentración geográfica de la producción. Estos hallazgos permiten afirmar que adoptar el comercio electrónico contribuye a la reconfiguración de la red de producción global, configurándose un proceso dinámico que vincula digitalización e internacionalización.
Los usos digitales como motor de crecimiento en clientes fans en la banca. Los casos de España y País Vasco
Authors:   EMO Insights International, Alfaro García Elena
Published: January 2025

¿Cómo visualizamos el futuro del crecimiento empresarial? ¿Vía digitalización, vía tecnología, vía obra social, vía servicio, etc.? Muchas son las apuestas que se están realizando por parte de las distintas compañías en busca de la clave. Sin embargo, la realidad es que estamos en una sociedad de constante transformación, donde la digitalización es protagonista y donde el contexto parece apuntar a una recesión. Esto aumenta la importancia de dar con la apuesta adecuada. Es urgente visualizar el camino de un crecimiento sostenible. Hay que aprovechar un hecho indiscutible: las emociones son algo innato en las personas y quienes conforman las organizaciones. El objetivo de este artículo es analizar cómo contribuyen los usos digitales a la vinculación emocional de las personas, en este caso clientes del sector bancario del País Vasco y del resto de España e identificar oportunidades a futuro mediante la generación de fans. Existen estudios internacionales que indican que la vinculación emocional es algo que genera valor económico. Si además tenemos en cuenta que las emociones guían las decisiones del ser humano, podemos concluir que hay una oportunidad en transformar emocionalmente los negocios como vía de crecimiento.
Smart specialisation strategies and energy transition: An exploratory analysis of the case of the Basque Country
Authors:   Orkestra, Magro Edurne , Wilson James R. ,   Orkestra, Aranguren Maria José ,   Orkestra
Published: January 2025

Energy transition is a core element of the sustainability transition around which the European Union’s post-COVID recovery strategies are built. While these strategies are being designed primarily by EU Member States, the regional level will be critical for their success. Firstly, because regions are key ‘implementers on-the ground’ of European and national policies. Secondly, because the lacespecificities of regions make them ideal ‘laboratories’ for experimenting with the innovations needed for sustainability transitions. This opens an important research question around how regional innovation policy, and more precisely how the regional smart specialisation strategies (S3) that have been developed over recent years, could provide a ‘ready-made’ framework for discovery and experimentation oriented explicitly to energy transitions. This paper explores this question by combining discussion of the concepts of S3 and energy transitions with an exploratory analysis of the S3 experience in the specific case of the Basque region. The paper highlights that moving from a S3 to a Sustainable S3 (or S4) will require enhancing the connectedness of different parts of existing strategies so that energy transition goals are approached in a holistic manner.
How are O&G companies contributing to the energy transition? A novel analytical framework for assessing sustainability strategies
Authors:   Orkestra, Menéndez Sánchez Jaime , Fernández Gómez Jorge ,   Orkestra, Araujo de la Mata Andrés ,   Universidad del País Vasco
Published: January 2025

Oil and gas (O&G) companies are progressively developing and adopting sustainability strategies in response to regulatory and market pressures embedded in the energy transition process. The UN’s Sustainability Development Goals (SDGs) are strongly linked to energy transitions and key to achieving successful sustainability strategies. A novel analytical framework to evaluate sustainability strategies is proposed and applied to the case study of Petronor, a refining company in the Basque Country (Muskiz, Bizkaia). The analysis helps to assess how O&G companies contribute to the energy transition by focusing on the SDGs. This first application of this framework suggests that a comprehensive understanding of an O&G company’s sustainability efforts is needed to fully evaluate its role in the energy transition.
Behavioral economics of the Covid-19 pandemic
Authors:   Universidad de Alicante, Jiménez Gómez David , Abellán Perpiñán José María ,   Universidad de Murcia
Published: January 2025

We study the Covid-19 pandemic from the point of view of behavioral economics, which combines economics and psychology. We analyze the biases (for example, optimism bias) that may have had a greater impact on decision-making regarding the pandemic, as well as potential public health policies from a behavioral economics perspective. We contrast the use of «nudges» (non-coercive measures that do not use economic incentives) with legislative measures, and we advocate for a comprehensive approach that jointly uses the best interventions available, to generate healthy habits (that reduce the transmission of the virus). Finally, we apply this approach to the promotion of vaccination.
Financial vulnerability of households: Evidence for the Basque Country and the rest of Spain
Authors:   BBVA, Arellano Alfonso , Cámara Noelia ,   BBVA
Published: January 2025

One of the consequences of the COVID-19 pandemic has been the loss of the main source of income for many households due to the lockdown of the workforce and the suspension of part of the economic activity. The aim of this paper is to analyze the importance of financial literacy and personal experiences with the financial system on financial vulnerability. We show evidence for households in the Basque Country and in comparison with the rest of Spain. Our research shows that controlling for multiple socio-demographic factors, households with lower financial literacy and who had some disagreement with the financial system are more likely to be very vulnerable. These effects are larger in the Basque Country than in the rest of Spain.
The fiscal and budgetary impact of COVID-19 pandemic on the public finances of the Basque Country: The Basque system of fiscal federalism put to the test
Authors:   Ituna Center for Basque Economic Agreement, Erkoreka Mikel
Published: January 2025

This article analyzes the fiscal and budgetary impact of the COVID-19 pandemic on the public finances of the Basque Country during 2020 and evaluates the performance and sufficiency of the system of fiscal federalism regulated by the Basque Economic Agreement. The research, which has a quantitative and qualitative character, employs the tools of fiscal and budgetary analysis – focusing on deficit and public debt management. The article concludes that the system of the Economic Agreement has withstood the demanding stress test provoked by the pandemic, maintaining unaltered the core principles that govern the Basque model of fiscal federalism: bilateralness in tax and financial relations between the Basque Country and the Spanish state, regulatory power and autonomy of tax management, and the principles of fiscal responsibility and unilateral risk.
La respuesta del Gobierno Vasco ante la COVID-19
Authors:   Gobierno Vasco, Jaca José Ignacio , Saizabal Iñigo ,   Gobierno Vasco
Published: January 2025

El objetivo de este artículo es analizar y cuantificar las iniciativas puestas en marcha por el Gobierno Vasco para hacer frente a la pandemia, así como al shock económico como consecuencia del proceso de hibernación forzosa derivadas del estado de alarma. Las actuaciones han combinado medidas sociales, basadas en un rápido y amplio reforzamiento de los sistemas sanitario y educativo, para adecuarlos a las nuevas circunstancias, y medidas económicas, para sostener la actividad económica y poner las bases para una rápida recuperación. En este último caso, se trata de medidas para mejorar la solvencia y la liquidez de las empresas, ofrecer ayudas a las personas y dar soporte a aquellos sectores y agentes más afectados. Asimismo, un segundo objetivo, complementario al anterior, es presentar el planteamiento a medio y largo plazo del Gobierno Vasco para acelerar la salida y recuperación de la crisis y hacer frente, lo antes posible, a los retos de este siglo aprovechando su potencial endógeno de inversión y poniendo en valor los fondos europeos Next Generation.
Biomarkers in Chronic Kidney Disease: Predicting Disease Progression and Treatment Response
Authors: Saad Aziz  , Medrar Ullah Khan  , Braikhna Amin  , Sikandar Ali Khan
Published: January 2025

Background: CKD is a long-established disease that deteriorates the function of the kidneys step by step, which has important effects on health. Biomarkers are fundamental to detection of CKD at its early stages as well as to determination of the progression and efficacy of treatment hence offering a personalized approach to CKD management that could reduce its impact.
Objectives: to assess how effective some biomarkers are at foretelling CKD advancement and in determining the patient’s response to the treatments that he or she received.
Study Design: A Cross-sectional study.
Place and duration of study. Department of Rheumatology, Lady Reading Hospital, Peshawar from 05 Jan 2023 to 05 Jan 2024
Methods: one hundred and twenty patients with CKD. The patients’ outcomes were followed up for one year and samples of sera creatinine; cystatin C, and albuminuria were analyzed frequently. Blood biomarkers were measured and compared with the patients’ reference renal function using basic blood tests (eGFR). Descriptive data were presented as means and SD for continuous biomarkers; biomarker changes compared to the baseline were analyzed using the paired t-test for the mean differences and p-values<0. 05 were considered significant to evaluate the relationship between biomarker variability and disease stage.
Results: baseline eGFR was 48. 5 ± 12. 4 mL/min/1. 73 m² in 120 patients. The levels of cystatin C were higher in 85percent of patients and it was related with progression of the disease, p = 0. 03 SD ± 1. 8. Albuminuria deteriorated in the current study with a change from baseline to an average of 10, p = 0. 01, suggesting the deterioration of renal function. Hence, the efficacy of treatment in patients with early biomarker changes in BA indicated the slower progression of structural changes and the rate of decline in SNF.
Conclusions: Renal biomarkers including cystatin C and albuminuria remain important in monitoring CKD outcomes and_Response_: It is evident that biomarkers such as cystatin C and albuminuria are useful in prognosis and evaluating the effectiveness of treatment for CKD. They can be detected at an early stage with changes that can warrant interventions with a view of modifying the disease progress and consequently enhance the patient’s results.
Keywords: Kidney disease, biochemistry, advancement, reaction to therapy
Cardiovascular Outcomes in Chronic Kidney Disease: Bridging the Knowledge Gap
Authors: Danish Ahmad Khan  , Owais  , Muhammad Sheheryar Khan  , Asma Gul
Published: January 2025

Background: Chronic kidney disease (CKD) is a global emerging health problem that has a well-established relationship with cardiovascular disease (CVD). The connection between CKD and CVD arises since these are associated with common risk factors, including hypertension and diabetes, causing high mortality rates. It is therefore important to establish the links between CKD and cardiovascular events so as to enhance the development of interventions.
Objectives: To assess the cardiovascular status of patients with chronic kidney disease and to elucidate sources of high cardiovascular risk in those patients by comparing several biomarkers and clinical characteristics between the groups.
Study Design: A descriptive cross-sectional study
Place and Duration of study: Department of General Medicine, Pak Emirates Military Hospital, Rawalpindi, Pakistan from March 2023 to june 2023
Methods: This was a descriptive cross-sectional study on 120 patients with CKD as follows; Cardiovascular health was determined with blood pressure, left ventricular hypertrophy (LVH) and protein biomarkers including troponin T and N-terminal pro-B-type natriuretic peptides (NT-proBNP). Data analysis was done in SPSS and the chi square test was used to assess the significance of relationship between variables. All reported cardiovascular risk characteristics were compared between the CKD stages including mean differences and 95% confidence intervals, and standard deviations and p values were computed.
Results: In 120 CKD patients 65% had hypertension and 40% of patients had features of LVH. The average troponin was 0. 05 (!) ng/mL ±0. 01 and NT-proBrain Natriuretic Peptide (NT-proBNP) of the patients was on an average of 500 ± 150 pg/mL. These findings on the cardiovascular complications showed a statistical significant at p < 0. 05 in the various CKD stages. SD for systolic blood pressure was ±12 mmHg ; p = 0. 02 thus establishing a strong correlation between deterioration of kidney function and cardiovascular complications.
Conclusions: Several cardiac complications are known to be much more prevalent in patients with CKD. Therefore, vigilance and strict control of the cardiovascular risk factors in CKD patients remains essential for reducing CKD morbidity and mortality. Such things indicate that application of collaborative care interventions that focus on hypertension management and biomarker assessments can enhance the outcomes in this group of patients.
The Prevalence and Genetic Factors of Pediatric Inflammatory Bowel Disease (IBD) in Different Populations A Retrospective Study.
Authors: Mohammad Iltaf  , Saqaib Ullah Khan  , Qazi Sidra Shafi  , Asma Khan
Published: January 2025

Background: Crohn’s disease and ulcerative colitis, also known as paediatric IBD is an emerging global issue. Their occurrence also greatly differs over the areas, hence genetic, environmental, and socio-economic differences. Both major gene variations affecting NOD2 and IL23R genes indicate genetic susceptibility to the disease and immune response and severity in a variety of populations.
Objectives: the frequency of paediatric IBD in other populations to Canadian children, the research project further compares the genetically predisposed markers with the severity of disease in pediatric subjects.
Study Design: A Retrospective Study.
Place and duration of study. Department of Gastroenterology Hayatabad medical complex Peshawar from January 2019 to July 2020
Methods: 100 P-IBD patients, specifically children, were followed up. Discrete measures were obtained from respondents on demographic features, family history, and disease severity. Targeted genetic testing of NOD2 and IL23R variants were conducted. Descriptive statistics incorporated SD for prevalence fluctuations and p-values for gene-related relationships. Inter regional group comparisons were made.
Results: 100 patients the average age was 12.3 (±2.1) years of age. NOD2 variants were observed in all cases tested and IL23R variants were seen in thirty percent of the patients. This was evident where prevalence varied significantly between North America and Asia only (p < 0.05). Crohn’s disease was higher than ulcerative colitis: 60% and 40%, respectively. Some of these demographics include: Family history came out strongly positive (F = 15.19, p < 0.01).
Conclusions: Geographical distribution of paediatric IBD has significant differences and strong association with NOD2 and IL23R polymorphisms. Prompt recognition of patients with genetic profiles related to the diseases can provide a more effective approach to their management, leading to better patient prognosis and lessor disease load.
Keywords: Pediatric IBD, Genetics, Incidence, Races
Evaluating Pediatric Intussusception Treatment Approaches and Prognostic Insights
Authors: Munazza Ibrahim  , Mujahid Aslam  , Shakeel Ur Rahman  , Shams Uz Zaman
Published: January 2025

Background: Intussusception exists as a frequent pediatric emergency in which parts of intestinal tissue fold inside adjacent segments leading to blockage. The condition develops primarily between children who are six months to three years old. When intussusception remainsundiagnosed treatmenteligible time frames complications such as bowel necrosis and perforation can occur. Researchers examined diagnostic precision alongside treatment success and intussusception trajectory to understand its medical outcomes in pediatric patients.
Objectives: to access diagnosis, therapeutic results and extended medical outcomes from intussusception treatment of 100 hospitalized pediatric patients within the Department of Gastroenterology MTI at LRH Peshawar should be assessed.
Study Design: A Retrospective Study.
Place and Duration of Study: Department of Gastroenterology, MTI, LRH Peshawar, from January 2019 to July 2023.
Methods: Medical records from pediatric intussusception cases totaling 100 patients (2019–2023) were examined. The researchers analyzed the observed symptoms together with X-ray results and treatment modalities and predicted medical outcomes. Three primary treatment methods consisting of ultrasound-guided air enema and conservative management and surgical procedures upheld intervention specificity. The research utilized standard deviation for statistical variability measurement and p-value (<0.05) as the main metric for proving statistical significance.
 
Results:  62 percent of the 100 patient group was male and their average age was 2.5 ± 0.6 years. Air enema successfully diagnosed 80% of intussusception cases but surgical intervention became necessary in 20%. Complications were observed in 7 patients (7%). On average patients stayed in the hospital for 2.6 ± 1.1 days. The success of treatment depended strongly on when patients sought medical help (x = 4.82; df = 1; p = 0.02).
 Conclusions: Timely diagnosis of pediatric intussusception combined with proper management leads to advantageous healing outcomes for children. Traditional air enema stands as the preferred treatment method which frequently avoids requiring surgical interventions. Every patient benefits from early medical response since most patients experience positive long-term results.
Keywords: Intussusception, Pediatrics, Diagnosis, Treatment
Exam Anxiety In Medical Students: Prevalence, Contributing Factors, And Mitigation Strategies.
Authors: Muhammad Bilal  , Hamna Wasiq  , Laiba Wasiq
Published: January 2025

Background: Medical students at high risk for exam anxieties experience negative effects that diminish both their study achievements and emotional health. Excessive course work together with unproductive time allocation and incomplete stress management skills lead to increased exam anxiety.
Objectives: Researchers studied the occurrence and elements causing exam stress and variations between genders in medical students learning at Nowshera Medical College.
Study Design: A cross-sectional study.
Place and duration of study. Department of Community Medicine, nowshera Medical College, from December 2024 to May 2024
Methods: A total of 200 MBBS students completed an online questionnaire which contained 22 questions during a cross-sectional study investigation. The researchers utilized Microsoft Excel for both descriptive and inferential statistical computations. The researchers secured both ethical approval and consent from participants before starting research activities.
Results: Participants averaged 21.5 years of age with a standard deviation of 2.1 years. Anxiety about exams existed in 77.5% of students (95 females alongside 60 males). Data analysis revealed meaningful differences between genders regarding their performance in time management (p < 0.05) as well as their fears of failure (p < 0.05) and their susceptibility to exam timing sensitivity (p < 0.05).
Conclusion: Medical female students and male students demonstrate clear differences in their experience of exam anxiety. Students develop exam anxiety because of the combination of academic pressure and bad study routines alongside inadequate guidance support. Students need effective stress-management techniques to enhance their overall wellbeing.
Keywords: Exam anxiety, medical students, stress, gender differences
Soft Booklet-Vol-1-Issue-1-2024 Jan to Dec -2024
Authors: Soft Booklet Copy current issue
Published: January 2025

softbooklet
OS IMPACTOS DAS REDES SOCIAIS NA BUSCA POR PROCEDIMENTOS ESTÉTICOS ENTRE ACADÊMICOS DE MEDICINA
Authors: Fernandes Manuela Luiza de Souza , Paraíso Alanna Fernandes , Rodrigues Augusto César Evelin , Silva Amanda Tauana Oliveira e , Diniz Sara Cristina Saraiva Batista , Bezerra Lana Vitória Santana , Borges Luna Viana
Published: January 2025

INTRODUÇÃO: Os procedimentos estéticos não cirúrgicos ou procedimentos cosméticos são tratamentos minimamente invasivos, usados para melhorar a aparência da pele e que englobam técnicas injetáveis de preenchimento como aplicação de toxina botulínica e ácido hialurônico que promovem o rejuvenescimento facial (Isaps, 2020; Ogilvie et al., 2020). OBJETIVO: Analisar o impacto das redes sociais na procura por procedimentos estéticos entre os estudantes de medicina de um Centro Universitário privado de Teresina-PI. MÉTODO: Tratou-se de um estudo transversal, descritivo com abordagem quantitativa e qualitativa. O estudo foi desenvolvido com 121 acadêmicos de medicina de uma instituição de ensino superior privada de Teresina – PI. RESULTADOS: A maioria da amostra (65,3%) pertencia ao sexo feminino e 59,5% dos participantes passa de 2 a 5 horas por dia nas redes, sendo o WhatsApp a plataforma mais utilizada (42,9%), seguida do Instagram (39,7%). Quando se trata da rede mais utilizada para pesquisar sobre procedimentos estéticos, 61,1% dos participantes escolhem o Instagram. Nessas redes, 93,3% dos participantes seguem influenciadores e celebridades e 76,9% seguem profissionais que trabalham com estética. Além disso, 42,2% dos participantes da pesquisa já realizaram procedimentos estéticos não cirúrgicos (botox, preenchedores, bioestimuladores, laser, ultrassons), 12,4% afirmaram já ter realizado procedimentos cirúrgicos e 9,1% ambos os procedimentos. Dentre os participantes 60,3% afirmaram que as redes sociais lhe induzem ao desejo de realizar procedimentos e 46,3% dos participantes afirmaram que a capacitação do profissional, currículo e formação é o fator mais importante na escolha do profissional para realizar procedimentos. CONCLUSÃO: O uso de mídias sociais se associa à maior probabilidade de estudantes de medicina, principalmente mulheres, submeterem-se à procedimentos estéticos.
Sosialisasi Pencegahan Pernikahan Dini Dan Seks Bebas
Authors: Amrina Rosyada  , Andrian  , Dian Indah Cahyani  , Hufzon Azhari  , Isni sapira  , Julia Wahyuni Saputri  , Liza Indah Safitri  , Nurhidayah  , Raodatul Hikmah  , Rusdan Bakri  , Wiwin Nurmayani  , Surya Jagat Lalu
Published: January 2025

This community service aims to provide outreach to students about the dangers of early marriage and free sex. Through this socialization activity on the prevention of early marriage and free sex, we are trying to increase students' and female students' awareness of the negative consequences of early marriage and free sex. This research involves a participatory approach, involving the community in planning and evaluating outreach activities.
Sosialisasi PKM Sekolah Sehat Tanpa Napza (Narkotika, Psikotropika, dan Zat Adiktif) Di MTs Al-Ayuda NW Salik
Authors: Susanti Erna Dwi , Harissuhud  , Liana Ida , Agustina Misro’ , M.Sugian  , Muh. Hendra Supriyanto  , Nira Azura  , Nurainun Putri  , Hariati Neza Ninda , Ulfa Iti Maria , Siskayan  , Putraidi Karyawan
Published: January 2025

Penyuluhan dan sosialisasi sekolah sehat tanpa napza bagi generasi muda sangat diperlukan khususnya pada siswa/siswi sekolah menengah dikarenakan generasi muda usia ini adalah masa depan Negara kita. merekalah yang nantinya akan menjadi penerus bangsa suatu hari nanti. Pelaksanaan penyuluhan melalui metode ceramah meupakan salah bentuk edukasi yang efisien untuk memberikan pemahaan dasar bagi peserta. Kegiatan Pkm Penyuluhan sekolah sehat tanpa napza ini bertujuan untuk meningkatkan kesadaran tentang bahaya penyalahgunaan napza, memberikan informasi yang akurat mengenai napza, serta membekali peserta dengan pengetahuan dan keterampilan untuk mencegah penyalahgunaan napza dikalangan masyarakat dan generasi muda, khususnya di Mts Al-Ayuda Nw Salik. hasil kegiatan Pkm penyuluhan sekolah sehat tanpa napza menunjukkan adanya peningkatan pengetahuan, klasifikasi, dampak, tujuan serta kewaspadaan para dewan guru serta para pemangku kepentingan dilingkungan rumah dan khususnya lingkungan sekolah.
Soliditas Kecintaan Terhadap Agama Dan Lingkungan
Authors: Sam’un Ahmad , Abdul Aziz  , L. Wildanip  , Laili Aulia Chofifah  , Lalu Sakirdan  , , Lalu Wiwid Suhendra  , Muhammad Zaini  , Nayli Nur Amalia  , Nisa Setiawani  , Saziah Fitriani  , Titik Nurmayanti  , Yulia Eka Ardiana  , Yuliana Ilmi  , Yulistia Ningsih
Published: January 2025

Program Kerja lingkungan bertujuan untuk meningkatkan solidaritas Masyarakat dusun Colok, Desa Bujak, Kecamatan Batukliang, Kabupaten Lombok Tengah, Provinsi Nusa Tenggara Barat (NTB) terhadap lingkungan dan perkembangan individu masyarakat serta kehidupan sosial-budayanya. Kegiatan tersebut dikemas dalam beberapa tema seperti agama, social-budaya, teknologi pedesaan/tepat-guna, pengembangan sumber daya manusia melalui pendidikan, serta menjaga sanitasi dan kesehatan lingkungan. Adapun metode dilaksanakan dalam kegiatan pemberdayaan Masyarakat melalui Kuliah Kerja Nyata ini adalah keterlibatan semua pihak di lingkungan masyarakat dengan Participatory Rural Appraisal (PRA) dan Focus Group Discussion (FGD). Kegiatan yang berhasil dilaksanakan adalah penataan lingkungan dengan melakukan gotong royong membersihkan lingkungan, jalan, saluran air dan penanaman tanaman hias. Adapun kegiatan non-fisik yang sudah dilaksanakan yaitu pembelajaran Al Qur’an, komputer dan sosialisasi Kesehatan serta pengecekan Kesehatan. Sebagai penutup pelaksanaan pemberdayaan masyarakat maka dilaksanakan kegiatan lomba keagamaan, penyerahan bantuan Al-Qur’an ke beberapa Tempat Pembelajaran Qur’an n (TPQ) serta malam penutupan tersebut dirangkai dengan pemberian hadiah.
Implementasi Sistem Informasi Desa (SID) untuk Meningkatkan Transparansi Pengelolaan Desa Lando Lombok Timur
Authors: Ezzad Zuliyanto  , Muzakkir  , Doni Rahman
Published: January 2025

Pemanfaatan SID bagi desa memberikan kemudahan dan efisiensi dalam pengelolaan data dan informasi di tingkat desa. Dengan adanya sistem yang terintegrasi, proses pengambilan keputusan dapat menjadi lebih cepat dan akurat. Selain itu, pemanfaatan teknologi informasi juga dapat membantu dalam memperluas akses informasi bagi masyarakat desa, sehingga mereka dapat terlibat secara aktif dalam pembangunan dan pengelolaan sumber daya lokal. Pengabdian ini dilakukan di desa landa lando lombok timur, bertujuan untuk implementasi Sistem Informasi Desa (SID) berbasis digital. Adapaun kegiatan yang dilakukan diantaranya pembetuan video profil desa, pendampingan UMKM dengan metode digital marketing dan digitalisasi pelayanan administrasi desa. Dari hasil yang sudah dilakukan masyakarat dapat memantau jarak jauh perkembangan desa melalui Youtube desa, website dengan dan lain-lain.
Pengaruh Pemanfaatan Media Pembelajaran Interaktif Artificial Intelegence Dalam Meningkatkan Hasil Belajar Ekonomi Kelas X Di SMA N 1 Pringgarata
Authors: Rudiman Hadi  , Marazaenal Adipta  , Mawarzani Sapka
Published: January 2025

Penelitian ini bertujuan untuk menguji ada atau tidaknya pengaruh media pembelajaran interaktif artificial intelegence terhadap hasil belajar kelas X di SMAN 1 Pringgarata. Jenis penelitian yang digunakan adalah quasi eksperimen dengan desain penelitian pretest posttest control group design. Instrumen yang digunakan adalah tes berupa soal-soal pilihan ganda. Sebelum instrumen tes diberikan, terlebih dulu dilakukan uji coba instrumen yaitu uji validitasdan reliabilitas. Populasi penelitian ini adalah semua peserta didik kelas X SMA Negeri 1 Pringgata. Pengambilan sampel penelitian ini menggunakan teknik purposive sampling. Kelas eksperimen diberi perlakuan dengan media pembelajaran interaktif artificial intelegence , sedangkan kelas kontrol dengan metode konvesional. Hasil analisis menunjukan skor rata-rata posttest hasil belajar ekonomi peserta didik yang diajarkan dengan media pembelajaran interaktif artificial intelegence adalah 76,38 dan peserta didik yang diajarkan dengan metode konvesional nilai rata-ratanya adalah 73,27. Hasil pengujian hipotesis yang menggunakan uji-t dengan bantuan IBM SPSS Statistic 27 menunjukkan nilai atau nilai , Maka Ha di terima dan  ditolak. Hal ini berarti terdapat pengaruh pemanfaatan media pembelajaran iteraktif Artificial Intelegence dalam meningkatkan hasil belajar Ekonomi Kelas X di SMAN 1 Pringgarata.
Peran Ekonomi Keluarga Dalam Memotivasi Minat Belajar Anak Perempuan Pada Sekolah Menengah Pertama (SMP) Di Desa Jeruk Manis Kecamatan Sikur Lombok Timur
Authors: Suandi  , Sanwani  , Sahabudin
Published: January 2025

Penelitian ini bertujuan untuk mengetahui Peran Ekonomi Keluarga dalam Memotivasi Minat Belajar Anak Perempuan Pada Sekolah Menengah Pertama (SMP) Di Desa Jeruk Manis Kecamatan Sikur Lombok Timur.Penelitian yang menghasilkan data deskriptif berupa kata-kata tertulis, lisan dari orang-orang dan pelaku yang diamati. pendekatan ini diarahkan pada batas individu tersebut secara utuh. Jadi, dalam hal ini tidak boleh mengisolasi individu atau organisasi ke dalam hipotesis, tapi perlu memandangnya sebagai bagian dari suatu keutuhan. Keadaan Ekonomi Keluarga Mayarakat Desa Jeruk Manis Kecamatan Sikur LombokTimur. Persoalan ekonomi memang tidak bisa terlepas dari lingkungan keluarga. Keadaan ekonomi menunjukkan pada taraf kemampuan finansial keluarga yang dapat bertarap cukup atau kurang. Cara Orang Tua Memotivasi Minat Belajar Anak Perempuan Desa Jeruk Manis Kecamatan Sikur LombokTimur.Peran Ekonomi Keluarga dalam Memotivasi Minat Belajar Anak Perempuan Desa Jeruk Manis Kecamatan Sikur LombokTimur
Hubungan Antara Pengetahuan Dengan Perilaku Pencegahan Skabies Pada Santriwati Pondok Pesantren
Authors: Aderita Novi Indah , Ningsih Surati
Published: January 2025

Prevalensi skabies di Indonesia mengalami penurunan dari tahun 2018-2020 (angka penurunan 6,9%). Namun masih menjadi masalah penyakit kulit menular. Skabies sering dialami pada daerah padat penghuni seperti pondok pesantren, sehingga perlu mendapatkan perhatian dengan melakukan pencegahan terhadap skabies. Faktor internal yang mendukung terbentuknya perilaku pencegahan skabies yaitu tingkat pengetahuan. Perilaku yang baik terhadap diri dan lingkungan merupakan langkah pencegahan penyakit skabies.  Tujuan dari penelitian ini adalah menganalisis hubungan antara pengetahuan dengan perilaku pencegahan skabies. Metode penelitian adalah korelasional dengan pendekatan cross sectional. Analisis data dengan Spearman’s rho. Pengambilan responden dengan total sampling dan didasarkan pada kriteria inklusi dan eksklusi. instrumen penelitian dengan kuesioner yang telah baku. Hasil penelitian menunjukkan bahwa dari 52 responden Sebagian besar mempunyai pengetahuan yang baik sebanyak 25 responden (48.1%) dan Sebagian besar mempunyai perilaku yang baik sebanyak 28 responden (53.8%). Hasil uji analisis antara pengetahuan dan perilaku pencegahan skabies diperoleh nilai signifikansi sebesar 0.000 (p < 0.01) artinya terdapat hubungan antara pengetahuan dengan perilaku pencegahan skabies. Simpulan: semakin baik pengetahuan tentang skabies maka semakin baik perilaku dalam upaya pencegahan skabies.