bluuebunny/crossref_metadata_2025 huggingface dataset:
Consumo de recursos ergogênicos por praticantes de musculação no município de marechal cândido Rondon -PR
Authors: Kerkhoven Simone , Alves Karina
Published: December 2023

Objetivo: Objetivou-se conhecer o consumo de recursos ergogênicos por praticantes de musculação do município de Marechal Cândido Rondon-PR. Métodos: O estudo caracterizou-se como um survey quantitativo. A população foi constituída por praticantes de musculação de cinco academias de Marechal Cândido Rondon – PR e a amostra foi composta por 212 indivíduos. Utilizou-se como instrumento um questionário com 17 questões. Foi empregado a descrição por porcentagem para apresentação dos resultados. Resultados: Os recursos ergogênicos mais comuns entre os praticantes de musculação foram os suplementos alimentares Whey Protein (93,4%), a Creatina (83%) e o BCAA (72,1%). Os fatores motivacionais para a utilização destas substâncias, foram as “possíveis melhoras no treinamento” (57%), por “recomendação nutricional ou médica” (27,3%) e “possíveis alterações estéticas” (16,9%). As principais fontes de indicação, foram os nutricionistas (31,6%), os professores de academia (20,2%), e amigos (18,4%). Conclusão: Conclui-se que o uso desregrado e imprudente de RE pode provocar efeitos graves à saúde. A partir disso, sugere-se novos estudos com aprofundamento nos efeitos do consumo desregrado e sobretudo, estratégias de conscientização da população quanto a utilização desses recursos.
Two birds with one stone: human SIRPα nanobodies for functional modulation and in vivo imaging of myeloid cells
Authors: Wagner Teresa R. , Blaess Simone , Leske Inga B. , Frecot Desiree I. , Gramlich Marius , Traenkle Bjoern , Kaiser Philipp D. , Seyfried Dominik , Maier Sandra , Rezza Amélie , Sônego Fabiane , Thiam Kader , Pezzana Stefania , Zeck Anne , Gouttefangeas Cécile , Scholz Armin M. , Nueske Stefan , Maurer Andreas , Kneilling Manfred , Pichler Bernd J. , Sonanini Dominik , Rothbauer Ulrich
Published: December 2023

Signal-regulatory protein α (SIRPα) expressed by myeloid cells is of particular interest for therapeutic strategies targeting the interaction between SIRPα and the “don’t eat me” ligand CD47 and as a marker to monitor macrophage infiltration into tumor lesions. To address both approaches, we developed a set of novel human SIRPα (hSIRPα)–specific nanobodies (Nbs). We identified high-affinity Nbs targeting the hSIRPα/hCD47 interface, thereby enhancing antibody-dependent cellular phagocytosis. For non-invasive in vivo imaging, we chose S36 Nb as a non-modulating binder. By quantitative positron emission tomography in novel hSIRPα/hCD47 knock-in mice, we demonstrated the applicability of 64Cu-hSIRPα-S36 Nb to visualize tumor infiltration of myeloid cells. We envision that the hSIRPα-Nbs presented in this study have potential as versatile theranostic probes, including novel myeloid-specific checkpoint inhibitors for combinatorial treatment approaches and for in vivo stratification and monitoring of individual responses during cancer immunotherapies.
Brain functional connectivity patterns associated with symptoms of vestibular migraine
Authors: Zhe Xia , Zhang Hailian , Tang Min , Lei Xiaoyan , Zhang Xiaoling , Jin Chenwang
Published: December 2023

Background

Several functional magnetic resonance imaging (fMRI) investigations of patients with vestibular migraine (VM) have revealed abnormal functionality in different networks, indicating that VM is related to alterations in brain function. We sought to investigate the resting-state functional connectivity (FC) patterns during the interictal period in VM by combining data-driven voxel-wise degree centrality (DC) calculations and seed-based FC analyses, and thereby determine the associations between cerebral function and clinical symptoms.

Methods

Thirty-eight patients with VM and 33 matched normal controls were recruited. DC was calculated and compared between the groups, and the FC of locations showing DC alterations was further tested using a seed-based technique. The participants’ clinical indicators were correlated with the DC and FC values of the brain areas.

Results

In contrast to the control group, the VM group showed considerably lower DC values in the bilateral medial prefrontal cortex (mPFC) and significantly higher DC values in the right occipital lobe. In the seed-based FC analyses, patients with VM demonstrated fewer connections of the bilateral mPFC with the bilateral posterior cingulate cortex, right parahippocampus, right cerebellar posterior lobe, bilateral cuneus, and left precuneus. In addition, clinical data from patients, such as pain intensity, episode frequency, and the Dizziness Handicap Inventory score, were negatively related to these FC and DC impairments.

Conclusion

Our findings showed changes in the default mode network and visual cortex in patients with VM, providing further insights into the complexity of the mechanisms underlying VM.
Hydrogel-encapsulated extracellular vesicles for the regeneration of spinal cord injury
Authors: Nazerian Yasaman , Nazerian Amirhossein , Mohamadi-Jahani Fereshteh , Sodeifi Parastoo , Jafarian Maryam , Javadi Seyed Amir Hossein
Published: December 2023

Spinal cord injury (SCI) is a critical neurological condition that may impair motor, sensory, and autonomous functions. At the cellular level, inflammation, impairment of axonal regeneration, and neuronal death are responsible for SCI-related complications. Regarding the high mortality and morbidity rates associated with SCI, there is a need for effective treatment. Despite advances in SCI repair, an optimal treatment for complete recovery after SCI has not been found so far. Therefore, an effective strategy is needed to promote neuronal regeneration and repair after SCI. In recent years, regenerative treatments have become a potential option for achieving improved functional recovery after SCI by promoting the growth of new neurons, protecting surviving neurons, and preventing additional damage to the spinal cord. Transplantation of cells and cells-derived extracellular vesicles (EVs) can be effective for SCI recovery. However, there are some limitations and challenges related to cell-based strategies. Ethical concerns and limited efficacy due to the low survival rate, immune rejection, and tumor formation are limitations of cell-based therapies. Using EVs is a helpful strategy to overcome these limitations. It should be considered that short half-life, poor accumulation, rapid clearance, and difficulty in targeting specific tissues are limitations of EVs-based therapies. Hydrogel-encapsulated exosomes have overcome these limitations by enhancing the efficacy of exosomes through maintaining their bioactivity, protecting EVs from rapid clearance, and facilitating the sustained release of EVs at the target site. These hydrogel-encapsulated EVs can promote neuroregeneration through improving functional recovery, reducing inflammation, and enhancing neuronal regeneration after SCI. This review aims to provide an overview of the current research status, challenges, and future clinical opportunities of hydrogel-encapsulated EVs in the treatment of SCI.
Navigating misinformation and political polarization of COVID-19: interviews with Milwaukee, Wisconsin county public health officials
Authors: Bates Garrett , Titi Mohammad , Dickson-Gomez Julia , Young Staci , Keval Aliyah , Meurer John
Published: December 2023

Introduction

The spread of misinformation combined with the political polarization of the COVID-19 vaccine created major challenges for public health officials responding to the COVID pandemic and vaccine roll-out. The challenges public health officials faced when making safety recommendations and promoting the vaccine only exacerbated the already exhausting work conditions they experienced since the start of the pandemic. Combating misinformation while receiving inadequate political support led to burnout for many public health officials. As such, they had to adapt and develop new strategies for increasing vaccine acceptance and decreasing vaccine hesitancies.

Method

This study was conducted through qualitative interviews with seven Milwaukee County public health officials. This study aimed to determine how public health officials perceived misinformation and political polarization during the pandemic. Additionally, the study aimed to learn more about strategies county health officials used to combat misinformation while increasing vaccine uptake in their communities.

Results

Thematic analysis of the interviews identified three major challenges faced by public health officials in promoting vaccination: dissemination of misinformation in media, political polarization of COVID and its contribution to vaccine acceptance and COVID fatigue, and assessment of the risks associated with disease severity versus vaccine safety considering limited public health resources.

Discussion

Learning from public health officials allows us to better understand their perceptions of the extent of local vaccine hesitancies and their advice on how to counteract fears and misinformation and to promote COVID vaccine uptake. Political polarization of COVID and misinformation affected community vaccine acceptance and challenged local public health leadership.
Intention and practice on personal preventive measures against COVID-19 among older adults in the Kingdom of Saudi Arabia: an epidemiological study using the Theory of Planned Behaviour
Authors: AlOmar Reem S. , AlHarbi Amal S. , Abu Abdullah Layla A. , Almuqbil Sarah M. , Albahrani Zahra S. , Aldar Hawra M. , Alzouri Fatimah S. , Al-Shiban Manar A. , AlShamlan Nouf A. , Shafey Marwa M. , AlAbdulKader Assim M. , Alotaibi Nijr S.
Published: December 2023

Introduction

Older adults aged 65 years and above are among the most vulnerable to adverse outcomes and death following a COVID-19 infection. The weekly epidemiological updates by the World Health Organisation show that the continued emergence of concerning subtypes of the virus indicates that the pandemic remains a public health concern and the public should continue to comply with personal preventive measures (PPMs). This study applies the Theory of Planned Behaviour (TPB) which is rooted in the field of Public Health, Epidemiology, and Preventive Medicine to Saudi older adults to predict their health behaviour.

Methods

This behavioural epidemiological study recruited older adult participants aged 65 years of age and above. A tool which consisted of sociodemographic and health-related questions, as well as questions regarding the components of the TPB, namely, Attitude, Subjective Norm, Perceived Behavioural Control was used. Bivariate analyses, followed by unadjusted and adjusted multivariable logistic regression analyses were performed to derive odds ratios and 95% confidence intervals.

Results

The total number of participants was 502. The mean age was 70.34 years, with similar distributions between males and females. In total, 52.2% intended to practice PPMs, whereas only 48% had a good practice. Also, 56% had a favourable Attitude towards PPMs, 61.4% had a positive Subjective Norm and 39.8% had perceived they had a high control over their behaviour. Females, and high educational status were predictors for high intention to practice PPMs (OR = 1.59, 95% CI = 1.01–2.52 and OR = 2.72, 95% CI = 1.44–5.16 respectively). Further predictors included Attitudes, Subjective Norm and Perceived Behavioural Control. Results also show that intention to practice was significantly associated with a lower odd of practicing PPMs (OR = 0.06, 95% CI = 0.04–0.10).

Conclusion

Current findings highlight the need to continue with public health efforts targeting vulnerable older adults. Also, the fact that intention negatively predicted practice highlights the need for further behavioural epidemiological studies addressing the intention-behaviour gap.
Integrated resistance management for acaricide use on Varroa destructor
Authors: Lester Philip J.
Published: December 2023

The global beekeeping industry faces an escalating challenge in the form of Varroa destructor. Synthetic chemicals serve as a cornerstone for varroa management, although they face a major challenge in the form of acaricide resistance. Here, I examine acaricide resistance in varroa under the framework of Insecticide Resistance Management (IRM). I assess the potential of diverse IRM strategies, such as pesticide rotation and mixtures, refuge utilization, synergists and the integration of non-persistent chemicals. The peculiar life history of varroa, characterized by its incestuous breeding system, challenges conventional IRM strategies. There is little published evidence that pesticide rotation is beneficial for resistance management in varroa, with several studies showing resistance is maintained despite rotation. Fitness costs associated with pesticide resistance are often an essential component for IRM strategies, but there are no current data from varroa demonstrating such specific fitness costs (e.g., a reduced relative oviposition rate) associated with resistance. The single published experimental study directly examining relative fitness found that here was little or no reproductive fitness cost associated with pyrethroid resistance. More work is needed on fitness effects of the key acaricides, which would better guide the use of rotation and refuge strategies. A key prospect for future work that has been identified through simulation modeling is offered by pesticide mixtures and the role of synergists to elevate acaricide efficacy. Additional tools for varroa IRM include ‘soft’ acaricides, including oxalic acid, and biopesticides such as dsRNA. In light of the widespread prevalence of acaricide resistance and an increasing varroa problem, there is an urgent need for nuanced, data-driven varroa IRM strategies.
Enhanced Low-Temperature Activity and Hydrothermal Stability of Ce-Mn Oxide-Modified Cu-SSZ-39 Catalysts for NH3-SCR of NOx
Authors: Tang Ahui , Yang Fuzhen , Xin Ying , Zhu Xiaoli , Yu Long , Liu Shuai , Han Dongxu , Jia Junxiu , Lu Yaning , Li Zhenguo , Zhang Zhaoliang
Published: December 2023

Cu-SSZ-39 zeolite with an AEI structure exhibits excellent hydrothermal stability and can be a potential alternative to Cu-SSZ-13 zeolite SCR catalysts for NOx removal in diesel vehicles. However, the inferior low-temperature performance of Cu-SSZ-39 leads to substantial NOx emissions during the cold-start period, impeding its practical application. In this study, Ce-Mn oxide-modified Cu-SSZ-39 catalysts (CeMnOx/Cu-SSZ-39) and references (CeO2/Cu-SSZ-39 and MnOx/Cu-SSZ-39) were prepared by the ion-exchange of Cu ions followed by impregnation of the oxide precursors, with the aim of enhancing the NH3-SCR performance at low temperatures. The modified catalysts exhibited improved low-temperature activity and hydrothermal stability compared to the unmodified counterpart. In particular, CeMnOx/Cu-SSZ-39 showed the highest activity among the three catalysts and achieved NOx conversions above 90% within the temperature range of 180 °C to 600 °C, even after undergoing hydrothermal aging at 800 °C. Experimental results indicated that the synergistic effect between Ce and Mn in CeMnOx improves the redox properties and acidity of the catalyst due to the presence of Ce3+, Mn4+, and abundant adsorbed oxygen species, which facilitate low-temperature SCR reactions. Furthermore, the interaction of CeMnOx with Cu-SSZ-39 stabilizes the zeolite framework and hinders the agglomeration of Cu species during the hydrothermal aging process, contributing to its exceptional hydrothermal stability. The kinetics and NO oxidation experiments demonstrated that CeMnOx provides access to fast SCR reaction pathways by oxidizing NO to NO2, resulting in a significant increase in low-temperature activity. This study provides novel guidelines for the design and preparation of Cu-SSZ-39 zeolite with outstanding SCR performance over a wide temperature range.
Mathematical Formulation of Learning and Its Computational Complexity for Transformers’ Layers
Authors: Pau Danilo Pietro , Aymone Fabrizio Maria
Published: December 2023

Transformers are the cornerstone of natural language processing and other much more complicated sequential modelling tasks. The training of these models, however, requires an enormous number of computations, with substantial economic and environmental impacts. An accurate estimation of the computational complexity of training would allow us to be aware in advance about the associated latency and energy consumption. Furthermore, with the advent of forward learning workloads, an estimation of the computational complexity of such neural network topologies is required in order to reliably compare backpropagation with these advanced learning procedures. This work describes a mathematical approach, independent from the deployment on a specific target, for estimating the complexity of training a transformer model. Hence, the equations used during backpropagation and forward learning algorithms are derived for each layer and their complexity is expressed in the form of MACCs and FLOPs. By adding all of these together accordingly to their embodiment into a complete topology and the learning rule taken into account, the total complexity of the desired transformer workload can be estimated.
Validation of NWCG Wildfire Directional Indicators in Test Burns in Coastal California
Authors: Parker Keith , Babrauskas Vytenis
Published: December 2023

One of the primary tools used for determining the origin of a wildfire is analyzing burn patterns formed during the fire progression. These patterns, called fire pattern indicators, are interpreted and used to document the direction of fire movement at specific points, creating a directional map back to the specific area of origin. This concept was first set forth in 1978 by a U.S. governmental organization, the National Wildfire Coordinating Group (NWCG). Their recommendations are currently (2016) in the third edition, and in our study, we examine these indicators. Specifically, the objective was to perform a validation exercise where controlled burns were conducted of natural vegetation plots but augmented with 32 identical sets of staged artifacts which would provide additional opportunities for fire movement to create observable directional fire pattern indicators. Three adjacent plots were burned, each using a single point ignition, all located on level, scrubland terrain. The burns were conducted in the fall season, under low to moderate burning conditions. The research was structured as a preliminary study, since only mild terrain and weather conditions were encompassed. The actual fire movements were documented by drone videos, additional ground-based videos, and still photography. Within the three burn plots, a total of 12 data sites out of 32 data sites were selected: each one containing 7 to 12 individual artifacts. Each artifact was photographically documented post-fire, and the actual fire movement direction at that location was established. Assessment entailed the use of four experienced wildland fire investigators, with each one independently assessing the direction and type of fire spread at each artifact using the photographic site evidence. An analysis was then conducted to make a statistical comparison between the actual fire movement direction and the direction estimates provided by the experts analyzing the photographic evidence and the limited information on conditions provided. The results indicate an average error of 103°. These results indicate that additional efforts are needed to study the scientific basis of the indicators and to evolve improvements in both the indicators and in the accompanying guidance to investigators.
Psychological Alterations in Youths with Type I Diabetes: Associations with Salivary Cortisol Concentration
Authors: El Mlili Nisrin , Ahabrach Hanan , Bahri Hind , Kerkeb Abdelilah , Mafla-España Mayra Alejandra , Cauli Omar
Published: December 2023

Background and Objectives: Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in children and adolescents, and is associated with stress and other psychological alterations. This study aims to assess psychological and sleep disorders and health-related quality of life in young people with T1DM and to determine the relationship between these parameters and levels of salivary cortisol, a hormone widely associated with stress and several psychological symptoms. Materials and Methods: In our cross-sectional study performed in 60 Moroccan children and adolescents with T1DM, detailed psychological evaluations were performed to assess symptoms of anxiety, attention-deficit hyperactivity disorder (ADHD), sleep quality and diabetes-specific quality of life (using the RCMAS-2, ADHD rating scale, Pittsburgh scale and the DQoL scale, respectively), and cortisol concentration was measured from saliva samples taken mid-morning. Results: A total of 60 children and adolescents with T1DM were recruited. The mean age was 11.05 ± 0.35 (6–17). The mean salivary cortisol level in ng/mL was 4.7 ± 0.49 (0.7–20.2) and was significantly associated with an anxiety RCMAS2 score for the Worry subdomain and DQoL subdomain “Anxiety”. Linear regression analysis showed that salivary cortisol was significantly higher in girls compared to boys (p = 0.004) (beta coefficient: 3.384 CI95%: 1.137–5.630) and with Hb1AC level as a continuous variable (p = 0.0001) (beta coefficient: 1.135 CI95%: 0.509–1.760). The other variables included in the model were not significant (p > 0.05). There was an association between salivary cortisol concentration with anxiety RCMAS2 score for Worry subdomain and QoL sub-domain “Anxiety”. Still, a significant (p = 0.018) association emerged for anxiety RCMAS2 score Worry subdomain and QoL anxiety subdomain (p = 0.044). Conclusions: Children and adolescents with T1DM experienced significantly elevated symptoms of anxiety and sleep disturbances, particularly in girls, and frequent symptoms of ADHD, particularly in boys. Salivary cortisol concentration collected in the morning is associated with anxiety burden but not with other psychological alterations. Further studies are needed to clarify the associations between salivary cortisol concentration and anxiety in type 1 diabetes in order to propose the hormone as a biomarker for interventions aimed to reduce anxiety levels in these patients.
Synthesis and Characterization of Iridium(III) Complexes with Substituted Phenylimidazo(4,5-f)1,10-phenanthroline Ancillary Ligands and Their Application in LEC Devices
Authors: Vásquez Bárbara , Bayas Max , Dreyse Paulina , Palma Juan Luis , Cabrera Alan R. , Rossin Elena , Natali Mirco , Saldias Cesar , González-Pavez Iván
Published: December 2023

In this work, we report on the synthesis and characterization of six new iridium(III) complexes of the type [Ir(C^N)2(N^N)]+ using 2-phenylpyridine (C1–3) and its fluorinated derivative (C4–6) as cyclometalating ligands (C^N) and R-phenylimidazo(4,5-f)1,10-phenanthroline (R = H, CH3, F) as the ancillary ligand (N^N). These luminescent complexes have been fully characterized through optical and electrochemical studies. In solution, the C4–6 series exhibits quantum yields (Ф) twice as high as the C1–3 series, exceeding 60% in dichloromethane and where 3MLCT/3LLCT and 3LC emissions participate in the phenomenon. These complexes were employed in the active layer of light-emitting electrochemical cells (LECs). Device performance of maximum luminance values of up to 21.7 Lx at 14.7 V were observed for the C2 complex and long lifetimes for the C1–3 series. These values are counterintuitive to the quantum yields observed in solution. Thus, we established that the rigidity of the system and the structure of the solid matrix dramatically affect the electronic properties of the complex. This research contributes to understanding the effects of the modifications in the ancillary and cyclometalating ligands, the photophysics of the complexes, and their performance in LEC devices.
Chitosan Soft Matter Vesicles Loaded with Acetaminophen as Promising Systems for Modified Drug Release
Authors: Hilițanu Loredana Nicoleta , Mititelu-Tarțău Liliana , Popa Eliza Grațiela , Bucă Beatrice Rozalina , Gurzu Irina Luciana , Fotache Paula Alina , Pelin Ana-Maria , Pricop Daniela Angelica , Pavel Liliana Lăcrămioara
Published: December 2023

Our study was designed to acquire, characterize and evaluate the biocompatibility of novel lipid vesicles loaded with acetaminophen (APAP) and coated with chitosan (CS). We investigated the in vitro and in vivo drug release kinetics from these systems, and we conducted assessments for both in vitro hemocompatibility and in vivo biocompatibility. For the in vivo biocompatibility evaluation, the mice were randomly divided into four groups of six animals and were treated orally as follows: control group: 0.1 mL/10 g body weight of double-distilled water; CS group: 0.1 mL/10 g body weight 1% CS solution; APAP group: 150 mg/kg body weight APAP; APAP-v group: 150 mg/kg body weight APAP-loaded lipid vesicles. The impact of APAP-v on various hematological, biochemical, and immune parameters in mice were assessed, and the harvested tissues were subjected to histopathological examination. The innovative formulations effectively encapsulating APAP within soft vesicles exhibited reasonable stability in solution and prolonged drug release in both in vitro and in vivo studies. The in vitro hemolysis test involving APAP-loaded vesicles revealed no signs of damage to red blood cells. The mice treated with APAP-v showed neither significant variances in hematological, biochemical, and immune parameters, nor structural changes in the examined organ samples, compared to the control group. APAP-v administration led to prolonged drug release. We can conclude that the APAP-v are innovative carrier systems for modifying drug release, making them promising candidates for biomedical applications.
Phytohormones and Pheromones in the Phycology Literature: Benchmarking of Data-Set and Developing Critical Tools of Biotechnological Implications for Commercial Aquaculture Industry
Authors: Rathod Sachin G. , Bhushan Satej , Mantri Vaibhav A.
Published: December 2023

Plant hormones and pheromones are natural compounds involved in the growth, development, and reproductive processes. There is a plethora of studies on hormones and pheromones in terrestrial plants, but such investigations are few in the phycological literature. There are striking similarities between the chemical diversity, biosynthetic processes, roles, and actions of hormones and pheromones in both higher angiospermic plants and algae. However, there are substantial knowledge gaps in understanding the genes responsible for hormone biosynthesis and regulation in algae. Efforts have focused on identifying the genes and proteins involved in these processes, shedding light on lateral gene transfer and evolutionary outcomes. This comprehensive review contributes to benchmarking data and essential biotechnological tools, particularly for the aquaculture industry where seaweed is economically crucial. Advanced techniques in plant hormones and pheromones can revolutionize commercial aquaculture by using synthetic analogs to enhance growth, yield, and reproductive control, thereby addressing seasonal limitations and enabling sustainable seedling production. To the best of our knowledge, this is the first comprehensive review that focuses on biosynthetic pathways and modes of action (of five plant hormones and five pheromones), roles (of 11 hormones and 29 pheromones), and extraction protocols (of four hormones and six pheromones) reported in the phycological domain.
LAPAROSCOPY FOR ACUTE PERITONITIS
Authors: Salakhov Eriken Kalymgireevich , Vlasov Aleksey Petrovich , Rubtsov Oleg Yur'evich , Zakharov Anton Anatol'evich , Kazakov Ruslan Rafael'evich , Dormidontov Mikhail Yur'evich
Published: December 2023

Peritonitis is the most serious complication of urgent abdominal diseases, associated with high mortality rates (up to 13 %).
The main component for complex peritonitis treatment is surgery. In some cases, it is carried out in several stages, that contributes to complete abdominal cavity sanitation.
The choice of surgical treatment (laparotomy / laparoscopy) is made individually, taking into account a number of parameters: the objective patient status, the clinical course of the disease, the material and technical equipment of the medical institution and the professional surgical skills.
It has been noted that laparoscopy for peritonitis, in contrast to laparotomy, is more sparing in terms of surgical access. Laparoscopy and laparotomy significantly reduce complications in the postoperative period, including wound complications and postoperative hernias. As a result, inpatient treatment decreases, and a better cosmetic effect is achieved.
However, the advisability of laparoscopy for patients with complex clinical manifestations of acute peritonitis remains a highly controversial issue.
Manzum Sözlük Geleneği Bağlamında Refî’-i Kâlâyî’nin “Lugât-i Ermeniyye”si Üzerine Bir İnceleme
Authors: ÇORUK Fatma Jale Gül
Published: December 2023

Yabancı dil öğretiminde yararlanılan ve ilk olarak Arap edebiyatında ortaya çıkan manzum sözlükler, 13. yüzyıldan itibaren Türk edebiyatında da yer edinmeye başlamıştır. Genel olarak Arapça, Farsça eksenli bir gelişim gösterdiği görülen manzum sözlük geleneğinin içinde Bulgarca, Boşnakça, Fransızca, Rumca vb. pek çok farklı dile ait metinler yazıldığı bilinmektedir. Çalışmamıza konu olan Lugât-i Ermeniyye de bu gelenek içinde yer alan manzum sözlüklerden biridir. XVIII. yüzyıl şairi Refî’-i Kâlâyî tarafından yazılmıştır. Çalışmamızda öncelikle Refî’-i Kâlâyî’nin edebî şahsiyeti hakkında genel bilgiler verilmiş ardından Lugât-i Ermeniyye ile bilinen ve bugüne değin bilinmeyen nüshaları hakkında genel bilgiler sunulmuştur. Çalışma dahilinde seçilen bir nüshanın transkripsiyonlu metni verilerek okuyucunun metni daha anlaşılır şekilde görmesi amaçlanmıştır. Ardından eserin şekil, dil ve muhteva özellikleri incelenerek metnin, manzum sözlük geleneği içindeki yeri saptanmaya çalışılmıştır. Yer alan edebî sanatlardan da bahsedilmiş ayrıca kelimelerin tamamına yakını belli konu başlıkları altında tablolar hâlinde tasnif edilerek sunulmuştur. Bu tablolarda Batı Ermenice transliterasyonuyla asılları ve okunuşları verilerek manzum sözlük yazımında rastlanan duyulduğu gibi yazma eğiliminin de daha anlaşılır kılınması amaçlanmıştır. Sonuç bölümünde ise elde edilen verilerin değerlendirilmesi yapılarak Lugât-i Ermeniyye’nin Türk manzum sözlük geleneği içindeki yeri belirlenmiştir.
Bergama Kozak Yöresinde Çam ve Çam Fıstığı
Authors: DİNÇER BAHADIR Şaziye
Published: December 2023

Ağız çalışmaları, hem kültürümüzü yansıtan hem de zamana karşı dayanıksız olan söz hazinesini ortaya çıkaran dil incelemelerimizin önemli bir koludur. Bu kolda, hem derleme hem de ortaya konulan metinlerden hareketle çeşitli ses, şekil bilgisi ve sözlük çalışmaları güncelliğini korumaktadır. Oldukça eski bir yerleşim yeri olan Bergama’nın Kozak yöresi, her yerleşim biriminde olduğu gibi karşılıklı etkileşimin, tarihin, geleneğin, göreneğin biçimlendirdiği bir ağız hazinesi olarak değerlendirilebilir.

Kozak yöresinde tarım ve hayvancılık dışında çam fıstığı önemli bir gelir kaynağıdır. Yöreye adını vermiş olan kozak, çeşitli kullanım alanlarına sahiptir. Çam fıstığı, misafirlere ikram olarak sunulmasının yanında tatlılarda da kullanılır. Çam ağaçlarının sadece fıstığından değil kerestesinden, odunundan, çırasından, sakızından, pürçeğinden de faydalanılır. Küneri alınmış kozalaktan elde edilen kıpır ve kıpçık yakacak olarak kullanılır. Baharda budanan çam dalları da küçükbaş hayvanlara yiyecek olarak verilir.

Çam fıstığı, yörenin ekonomisine olduğu gibi kültürüne de etki etmiştir. Bu yörede çam ve çam fıstığıyla ilgili söz varlığı oldukça zengindir. Bu çalışmada, Bergama Kozak yöresi ağzında çam ve çam fıstığı ile ilgili söz varlığı belirlenecek ve sonucunda çam ve çam fıstığı ile ilgili söz varlığının yok olması engellenmiş olacaktır.
Evaluation of Current Professional Practices of Perfusionists: Survey Study
Authors: AMAÇ Bişar , BAĞIŞ Murat Ziya
Published: December 2023

Introduction: Cardiac surgical procedures performed with extracorporeal circulation or perfusion techniques retain their importance in treating heart disease and often represent an alternative method.

Objective: This survey aimed to identify and evaluate the current practice of perfusionists in cardiovascular surgery clinics in Turkey.

Materials and Methods: This study is a prospective and descriptive etiological study. Surveys regarding the current practices of perfusionists were created as part of the study. The created surveys were sent to perfusionists in Turkey voluntarily through the application "Google Forms", and the data were collected. The data obtained from the surveys were statistically analyzed.

Results: In this study, 80 perfusionists from 28 centres participated in the survey. Thirty-four participants were under 30 years old, 12 were between 31 and 35 years old, 16 were between 36 and 40 years old, and 16 were over 40 years old. Of the participants, 46 were female and 34 were male. The study collected descriptive data, information on cardiac clinics, CPB practices, use of cardioplegia, and other assistive devices.

Conclusion: There have been significant advances and changes in cardiac surgery surgeries performed with CPB over approximately 70 years from the past to the present. However, we believe that there are ongoing or pending issues.
HAK DÜŞÜRÜCÜ SÜRELERİN DAVA ŞARTI OLARAK NİTELENDİRİLME(ME)Sİ
Authors: PEKSÖZ Vildan
Published: December 2023

Hak düşürücü sürelerin itiraz olduğu yönünde görüşler bulunmakla beraber dava şartı olduğu ifadelerine de rastlanmaktadır. Bu çalışmada hak düşürücü sürelerin ilişkin olduğu hak veya yetkiye göre bu sürelerin sona ermesinin yargılamaya etkisinin ne yönde olacağının tespiti yapılacaktır. Hak düşürücü süre usûlî işleme ya da icra işlemine yönelik olduğunda sürenin sona ermesi, esas hakka etki etmeksizin, o işlemi yapma hakkını/yetkisini sona erdirebilmektedir. Hak düşürücü süre esas hakka ilişkinse sürenin sona ermesiyle birlikte hak da sona erer. Hakkın sona ermesi maddî hukuka yönelik savunma sebeplerinden itiraz teşkil eder. Süreye bağlı hakta da sürenin sona ermesi, hakkı sona erdirdiğinden itiraz olarak kabul edilmelidir. Bununla birlikte esas hak sona ermemekle beraber hak düşürücü sürenin sonunda hakkın dava konusu yapılması engelleniyorsa dava edilebilirlik noksanlığı ortaya çıkar. Esası incelemeye engel olan bu eksiklik, dava şartı olarak kabul edilmelidir. Dava açma süresinin usûlî olduğu bu durumlarda, kimi zaman dava edilebilirlik belirli alanlarla sınırlı olarak ortadan kalkmaktadır.
Hubungan Perdarahan Antepartum Pada Ibu Bersalin Dengan Kejadian Asfiksia di Rumah Sakit Umum Daerah Ade Muhammad Djoen Kabupaten
Authors: Lea Masan  , Elvi Juliansyah  , Yunida Haryanti  , Yolanda Montesori  , Rizki Amartani
Published: December 2023

Asfiksia merupakan keadaan dimana bayi baru lahir tidak dapatbernafas secara spontan dan teratur. Asfiksia merupakanmasalah yang menyebabkan tingginya tingkat morbiditas danmortalitas pada neonatus. Faktor resiko terjadinya asfiksiadiantaranya adalah perdarahan antepartum. Data rekam medisdi sebanyak 900 persalinan. Penelitian ini bertujuan untukmengetahui perdarahan antepartum. Penelitian ini bersifatanalitik kuantitaf menggunakan pendekatan retrospektif.Populasi dalam penelitian ini adalah seluruh bayi yang lahir diRumah Sakit Ade M. Djoen Sintang tahun 2020. Teknik sampelyang digunakan yaitu random sampling, dengan total sampelsebanyak 90 sampel. Analisis data menggunakan analisisunivariat dan analisis bivariat dengan taraf signifikan 5%.Penelitian ini menggunakan uji statistik Chi Square. Hasilpenelitian ini didapatkan ada hubungan perdarahan antepartum,diperoleh nilai Pvalue = 0,023 (≤0,05) dengan nilai OR = 2,941yang berarti bahwa perdarahan antepartum beresiko 2 kalimelahirkan bayi dengan kejadian asfiksia. Ada hubungan antaraperdarahan antepartum dengan kejadian asfiksia. Diharapkanperan tenaga kesehatan sebagai pemberi pelayanan melakukandeteksi dini pada saat antenatal care sehingga dapat mengatasiapabila ibu hamil beresiko untuk mengalami perdarahanantepartum sehingga kejadian asfiksia secara dini dapatdihindari.
Pengaruh Penggunaan Gymball dan asuhan Sayang Ibu Terhadap Pengurangan Rasa Nyeri Pada ibu Bersalin Kala I Di Kilinik Budi Mulia Medika Tahun 2023
Authors: Theresia Shella Beredikta  , Gunarmi Gunarmi , Juda Juda Julia Kristiani
Published: December 2023

Angka kematian ibu di Indonesia masih menjadi masalahutama hal tersebut disebabkan oleh nyeri persalinan yanglama diatasi saat menjelang maupun proses prasalianan.Nyeri yang tidak teratasi menyebabkan pernafasan dan denyutjantung ibu akan meningkat sehingga aliran darah dan oksigenke plasenta terganggu yang berdampak pada kematian ibu danbayi. Tujuan Penelitian ini adalah melihat PengaruhPenggunaan Gymball Dan Asuhan Sayang Ibu Terhadap RasaNyeri Persalinan Kala I Di Klinik Budi Mulia MedikaPalembang Tahun 2023. Metode penelitian ini merupakanjenis penelitian kuantitatif. Rancangan yang digunakan dalampenelitian ini adalah rancangan eksperimen (quasyexperiment) yaitu dengan melihat perubahan nyeri persalinankala I fase aktif menggunakan lembar observasi dankuesioner. Desain yang digunakan pada penelitian ini adalahtwo group only post test desain. Populasi dalam penelitian iniadalah semua ibu hamil yang bersalin pada bulan Maret 2023dengan Jumlah 30 orang ibu bersalin normal di Klinik BudiMulia Medika Palembang. Jadi total sampel dalam penelitianini adalah 30 ibu bersalin, yang dibagi menjadi 15 sebagaikelompok intervensi dan 15 kelompok kontrol. Tekniksampling yang digunakan yaitu nonprobability samplingdengan pendekatan purposive sampling. Kelompokeksperimen dan kelompok kontrol mayoritas tidak bekerja 9(60,0%) kelompok eksperimen 10 (66,7%). Pada uji pairetsampel t-Test kelompok ekperimen didapatkan p-value0,000< 0,05 dan kelompok kontrol diperoleh hasil p-value0,000< 0,05 sebelum dan sesudah intervensi terdapatpengaruh intervensi terhadap kelompok eksperimen dankelompok kontrol, namun pada uji Independen t-test tidakterdapat pergaruh yang efektif antara intervensi kelompokeksperimen dan kelompok eksperimen.Kesimpulan : Gymballdan Asuhan Sayang ibu merupakan upaya non farmakologiyang dapat digunakan dalam penurunan nyeri persalinan padaibu hamil Kala I fase aktif
Pengaruh Pemberian Penyuluhan Kesehatan Reproduksi Remaja Terhadap Perilaku Seksual Pada Remaja
Authors: Liza  , Refya  , Amelia
Published: December 2023

Hasil studi pendahuluan melalui wawancara langsung terhadapremaja di Posyandu Remaja AurKenali Kota Jambi, beberapaantaranya masih tidak mengerti mengenai kesehatan reproduksiserta kiat dalam menjaga dan beradaptasi dengan pertumbuhandan perkembangan yang erat kaitannya dengan perilaku seksualdirinya pernah berpacaran. Selain itu mereka juga pernahmelakukan perilaku-perilaku seks yang berpotensi dapatmenyebabkan penyebaran penyakit seperti berpelukan,berciuman, dan juga bahkan berhubungan seperti suami istri.Mengidentifikasi pengaruh pemberian penyuluhan kesehatanreproduksi remaja terhadap perilaku seksual pada remaja putri diDi Posyandu Remaja Aur Kenali Kota Jambi tahun 2023.Penelitian ini menggunakan metode Quasi Eksperimen tanpakelompok kontrol dengan pendekatan One Group Pre test -Post test Design. Sebelum perlakuan diketahui bahwa perilakuseksual anak yang baik sebanyak 13 responden (43,3%) danyang kurang sebanyak 17 responden (56,15%), setelah perlakuandiketahui bahawa perilaku seksual anak yang baik sebanyak 28responden (93,3%) dan yang kurang sebanyak 2 responden(6,6%). Hasil uji statistik didapatkan nilai signifikan 0,000 <0,05. Ada pengaruh pemberian penyuluhan kesehatanreproduksi remaja terhadap perilaku seksual pada remaja putridi Posyandu Remaja AurKenali Kota Jambi
Hubungan antara Pengetahuan, Pendidikan dan Pekerjaan Ibu dengan Pemberian ASI Ekslusif
Authors: Bina Aquari  , Heru Listiono
Published: December 2023

ASI merupakan sumber nutrisi yang penting untukperkembangan bayi khususnya pada 6 bulan pertama setelahia dilahirkan. Melansir dari laman Kementerian KesehatanRI, ASI mengandung zat seperti DHA, AA, Omega 6,laktosa, vitamin A, protein, lemak, zat besi dan masihbanyak lagi yang dibutuhkan oleh bayi. Oleh karena itu, ASIsangat penting untuk membentuk sistem imun di tubuh bayi.Berdasarkan hasil wawancara dengan 30 responden ibumengatakan alasan tidak memberikan ASI Ekskusif kepadaanaknya tidak yakin dengan kecukupan ASI yang diberikankepada bayinya. Berdasarkan latar belakang tersebutpeneliti tertarik untuk meneliti judul Hubungan AntaraPengetahuan, Pendidikan, dan Pekerjaan Ibu denganPemberian ASI Ekslusif di Klinik / Anisa Desa MainanKecamatan Sembawa Kabupaten Banyuasin Tahun 2023”.Penelitian ini merupakan penelitian deskriptif kuantitatifdengan metode pendekatan secara cross sectional. Penelitiandilakukan di Klinik/BP Anisa Kabupaten Banyuasin.Pengambilan data dilakukan pada bulan maret 2023 s/dAgustus 2023 dengan teknik purposive sampling sebanyak30 responden. Variabel independent dalam penelitian iniadalah variabel pendidikan, pengetahuan, pekerjaan danvariabel motivasi sedangkan variable dependent yaitupemberian Asi Eksklusif pada bayi. Alat ukur yangdigunakan adalah kuesioner. Uji statistik dilakukan pada 30responden dengan menggunakan analasis univariat dananalisi bivariat ada hubungan yang signifikan antarapendidikan, pengetahuan, pekerjaan ibu dengan pemberianAsi Eksklusif pada bayi
Faktor faktor yang berhubungan dengan kejadian Anemia pada ibu hamil
Authors: Titik Almujahidiani  , Rini Mayasari
Published: December 2023

meningkatkan risiko terhadap ibu dan bayi. Suplementasi merupakan strategi penting dalam menanggulangi defisiensi zat gizi mikro pada wanita. Menurut WHO  2020 prevalensi anemia pada ibu hamil di seluruh dunia telah mengalami penurunan sebanyak 4,5% selama 19 tahun terakhir, sedangkan di Indonesia pada tahun 2019 angka kejadian anemia pada ibu hamil meningkat 44,2%. Berdasarkan Hasil Riskesdas 2018 menunjukan bahwa di Indonesia sebesar 48,9% ibu hamil mengalami anemia. Sebanyak 84,6% anemia pada ibu hamil terjadi pada kelompok umur 15-24 tahun. Metode yang digunakan dalam penelitian adalah Survey analitik dengan pendekatan cross sectional. uji statistic yang digunakan adalah Chi-Square. Populasi penelitian adalah semua ibu hamil di wilayah Puskesmas Cambai Kota Prabumulih dengan total populasi 30 responden yaitu secara random sampling. Ada hubungan antara hubungan antara Umur ibu, Pendidikan dan Paritas dengan kejadian anemia pada ibu hamil di Puskesmas Cambai Kota Prabumulih Tahun 2023 dengan nilai p value 0,004, 0,046 dan 0,079. Petugas kesehatan diharapkan dapat melakukan promosi kesehatan dengan memberikan informasi tentang pentingnya mengkonsumsi tablet zat besi yang tepat serta Ibu hamil diharapkan untuk lebih aktif dalam usaha pencegahan anemia saat kehamilan dengan cara selalu rutin selalu rutin melakukan ANC.

Kata Kunci : Kejadian Anemia, Pendidikan, Umur, Paritas
Hubungan Gangguan Pemenuhan Waktu Tidur pada Ibu Nifas dengan Kejadian Postpartum Blues
Authors: Yuni Kurniati  , Juliana Widyastuti Wahyuningsih
Published: December 2023

Postpartum blues adalah adanya gangguan perasaan yang terjadi pada ibu pasca melahirkan dimana akan muncul pada hari pertama sampai dua minggu yang dapat ditandai dengan kecemasan, serangan panik, kelelahan, perasaan menyalahkan diri dan merasa tidak mampu mengurus bayinya. Angka kejadian di Indonesia pada ibu yang mengalami postpartum blues sebesar 50% sampai 70%. Kelelahan yang dialami ibu dapat disebabkan karena faktor gangguan tidur sehingga kondisi seseorang mengalami kelainan pada pola tidur. Kondisi ini menyebabkan penurunan kualitas tidur yang berdampak pada kesehatan secara keseluruhan. Desain penelitian ini merupakan penelitian analitik kuantitatif dengan pendekatan cross sectional, yang bertujuan untuk mengetahui hubungan gangguan tidur ibu nifas dengan kejadian postpartum blues. Populasi dalam penelitian ini adalah semua ibu nifas yang berkunjung di klinik Budi Mulia Medika. Sampel penelitiannya berjumlah 34 ibu nifas pada hari ke-3 sampai hari ke-10 dengan menggunakan purposive sampling.  Penelitian ini telah dilakukan di Klinik Budi Mulia Medika. Waktu penelitian dilakukan pada bulan 23 Agustus sampai 30 Oktober 2023. Tehnik pengumpulan data menggunakan kuesioner. Analisis statistik menggunakan uji korelasi Rank Spearman. Dari hasil uji korelasi Rank Spearman dapat diketahui tingkat kekuatan (keeratan) hubungan variabel kejadian postpartum blues dengan kejadian gangguan tidur. Diperoleh angka koefisien korelasi sebesar 0,577**. Artinya, tingkat kekuatan hubungan (korelasi) antara variabel kejadian postpartum blues dengan kejadian gangguan tidur adalah sebesar 0,577 atau sangat kuat dengan adanya tanda (**) artinya korelasi bernilai signifikan pada angka signifikasi sebesar 0,01. Angka koefisien korelasi, bernilai positif yaitu 0,577, sehingga hubungan kedua variabel tersebut bersifat searah, dapat diartikan bahwa kejadian gangguan pemenuhan kebutuhan tidur pada ibu nifas yang semakin meningkat maka akan meningkatkan kejadian pospartum blues pada ibu nifas. Karena nilai  p = 0,000 < 0,05 artinya ada hubungan signifikan antara variabel kejadian gangguan tidur dengan kejadian postpartum blues.
Pengaruh Senam Nifas terhadap Involusi Uteri pada Ibu Nifas Normal
Authors: Isnaeni Siti , Sari Ossie Happina , Kumalasari Retno
Published: December 2023

Pembangunan nasional di bidang kesehatan berkaitan erat dengan peningkatan mutu sumber daya manusia yang merupakan modal dasar dalam melaksanakan pembangunan kesehatan. Salah satu indikator untuk menentukan derajat kesehatan suatu bangsa ditandai dengan tinggi rendahnya kematian ibu dan bayi. Senam nifas adalah salah satu cara untuk bergerak setelah bersalin. Senam ini memperbaiki sirkulasi darah, sikap tubuh, dan kekuatan otot panggul, perut, dan tungkai bawah. Selama masa nifas, yang sangat penting bagi ibu dan bayi, sangat penting untuk mendapatkan perawatan yang tepat. Kecepatan Involusi uteri dipengaruhi oleh beberapa faktor yaitu senam nifas, menyusui dini, ambulasi dini, gizi, paritas, psikologis, dan umur. Tujuan penelitian ini adalah untuk mengetahui pengaruh senam nifas terhadap involusi uteri pada ibu  nifas normal di pada salah satu Praktik Mandiri Bidan. Jenis penelitian yang digunakan adalah penelitian eksperimen dengan desain penelitian adalah Pretest-posttest Design. Analisis yang dilakukan terhadap dua variabel yang diduga berhubungan atau berkorelasi. Penghitunagn analisis bivariat ini juga akan menggunakan komputerisasi. Analisis penelitian ini menggunakan uji statistik dengan Paired t Test. Involusi uteri sebelum dilakukan senam nifas pada ibu nifas normal dengan dilakukan pengukuran TFU yaitu 11 cm - 16 cm. Involusi uteri setelah dilakukan senam nifas pada ibu nifas normal dengan dilakukan pengukuran TFU yaitu 7,5 cm – 12 cm. Hasil uji statistik diperoleh nilai t-tabel = 1,729 dan t hitung = 18,618 ( t hitung > t-tabel ), berarti ada pengaruh senam nifas terhadap involusi uteri pada ibu nifas normal.