bluuebunny/crossref_metadata_2025 huggingface dataset:
Informal caregivers of older Muslims diagnosed with cancer: A portrait of depression, social support, and faith
Authors: Baider Lea , Goldzweig Gil , Jacobs Jeremy M. , Ghrayeb Ibtisam M. , Sapir Eli , Rottenberg Yakir
Published: June 2021

Objective

Islamic population constitute more than 20% of the world population and is growing rapidly. Nevertheless, data concerning informal caregiving to older Muslim patients diagnosed with cancer are scarce. Improving the well-being of caregivers is a vital step to optimal care for the patients themselves throughout the Muslim community and the world. This study focuses on a sample of Palestinian caregivers of older Muslim patients diagnosed with cancer living in East Jerusalem, the West Bank, and Gaza. The study aims to describe the socio-demographic characteristics of the caregivers and to understand their social support, and identify predictors of caregivers’ depression.

Methods

A cross-sectional study of a convenience sample of 99 dyads of Palestinian patients (age ≥65) and their informal caregivers. Depression and social support were measured using the five items of the Geriatric Depression Scale and the Cancer Perceived Agents of Social Support questionnaire.

Results

Caregivers were most frequently adult children (52%) or spouses (32%), with male patients cared for by spouses (47.5%) or sons (32%), and female patients by daughters (50%). Clinical levels of depression were reported by 76% of the caregivers and 85% of patients. The significant predictors of caregiver depression were female gender, lower education, lower perceived social support from spouse and family, and higher perceived support from faith.

Significance of results

Healthcare providers serving the study population should determine the position and role of the caregiver within the social and family structure surrounding the patients’ families. This understanding may facilitate overcoming barriers to effective and meaningful social support.
The contractualization of fiscal and parliamentary sovereignty: Towards a private international finance architecture?
Authors: Bantekas Ilias
Published: June 2021

A state should be deemed to be enjoying fiscal sovereignty where it is effectively empowered, without pressure or coercion, to make all policy decisions required to run the state machinery and satisfy the fundamental needs of its people (at the very least), both individual and collective. A state’s effective policy and decision-making power is effectively curtailed where: (1) it has been substituted in these functions by a third state or an organ of that state; (2) it is prevented from taking a particular action, such as unilateral default; (3) it is forced to violate fundamental domestic laws, including its constitution or the result of a referendum; or (4) external pressure is exerted against its government and institutions, with the aim of creating volatility and uncertainty concerning its finances so it succumbs to such pressure.
Diagnostic and prognostic potential of the proteomic profiling of serum-derived extracellular vesicles in prostate cancer
Authors: Signore Michele , Alfonsi Romina , Federici Giulia , Nanni Simona , Addario Antonio , Bertuccini Lucia , Aiello Aurora , Di Pace Anna Laura , Sperduti Isabella , Muto Giovanni , Giacobbe Alessandro , Collura Devis , Brunetto Lidia , Simone Giuseppe , Costantini Manuela , Crinò Lucio , Rossi Stefania , Tabolacci Claudio , Diociaiuti Marco , Merlino Tania , Gallucci Michele , Sentinelli Steno , Papalia Rocco , De Maria Ruggero , Bonci Désirée
Published: June 2021

Extracellular vesicles (EVs) and their cargo represent an intriguing source of cancer biomarkers for developing robust and sensitive molecular tests by liquid biopsy. Prostate cancer (PCa) is still one of the most frequent and deadly tumor in men and analysis of EVs from biological fluids of PCa patients has proven the feasibility and the unprecedented potential of such an approach. Here, we exploited an antibody-based proteomic technology, i.e. the Reverse-Phase Protein microArrays (RPPA), to measure key antigens and activated signaling in EVs isolated from sera of PCa patients. Notably, we found tumor-specific protein profiles associated with clinical settings as well as candidate markers for EV-based tumor diagnosis. Among others, PD-L1, ERG, Integrin-β5, Survivin, TGF-β, phosphorylated-TSC2 as well as partners of the MAP-kinase and mTOR pathways emerged as differentially expressed endpoints in tumor-derived EVs. In addition, the retrospective analysis of EVs from a 15-year follow-up cohort generated a protein signature with prognostic significance. Our results confirm that serum-derived EV cargo may be exploited to improve the current diagnostic procedures while providing potential prognostic and predictive information. The approach proposed here has been already applied to tumor entities other than PCa, thus proving its value in translational medicine and paving the way to innovative, clinically meaningful tools.
Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3
Authors: Santini Laura , Halbritter Florian , Titz-Teixeira Fabian , Suzuki Toru , Asami Maki , Ma Xiaoyan , Ramesmayer Julia , Lackner Andreas , Warr Nick , Pauler Florian , Hippenmeyer Simon , Laue Ernest , Farlik Matthias , Bock Christoph , Beyer Andreas , Perry Anthony C. F. , Leeb Martin
Published: June 2021

In mammalian genomes, differentially methylated regions (DMRs) and histone marks including trimethylation of histone 3 lysine 27 (H3K27me3) at imprinted genes are asymmetrically inherited to control parentally-biased gene expression. However, neither parent-of-origin-specific transcription nor imprints have been comprehensively mapped at the blastocyst stage of preimplantation development. Here, we address this by integrating transcriptomic and epigenomic approaches in mouse preimplantation embryos. We find that seventy-one genes exhibit previously unreported parent-of-origin-specific expression in blastocysts (nBiX: novel blastocyst-imprinted expressed). Uniparental expression of nBiX genes disappears soon after implantation. Micro-whole-genome bisulfite sequencing (µWGBS) of individual uniparental blastocysts detects 859 DMRs. We further find that 16% of nBiX genes are associated with a DMR, whereas most are associated with parentally-biased H3K27me3, suggesting a role for Polycomb-mediated imprinting in blastocysts. nBiX genes are clustered: five clusters contained at least one published imprinted gene, and five clusters exclusively contained nBiX genes. These data suggest that early development undergoes a complex program of stage-specific imprinting involving different tiers of regulation.
A dynamic basal complex modulates mammalian sperm movement
Authors: Khanal Sushil , Leung Miguel Ricardo , Royfman Abigail , Fishman Emily L. , Saltzman Barbara , Bloomfield-Gadêlha Hermes , Zeev-Ben-Mordehai Tzviya , Avidor-Reiss Tomer
Published: June 2021

Reproductive success depends on efficient sperm movement driven by axonemal dynein-mediated microtubule sliding. Models predict sliding at the base of the tail – the centriole – but such sliding has never been observed. Centrioles are ancient organelles with a conserved architecture; their rigidity is thought to restrict microtubule sliding. Here, we show that, in mammalian sperm, the atypical distal centriole (DC) and its surrounding atypical pericentriolar matrix form a dynamic basal complex (DBC) that facilitates a cascade of internal sliding deformations, coupling tail beating with asymmetric head kinking. During asymmetric tail beating, the DC’s right side and its surroundings slide ~300 nm rostrally relative to the left side. The deformation throughout the DBC is transmitted to the head-tail junction; thus, the head tilts to the left, generating a kinking motion. These findings suggest that the DBC evolved as a dynamic linker coupling sperm head and tail into a single self-coordinated system.
Ni-catalyzed hydroaminoalkylation of alkynes with amines
Authors: Yao Wei-Wei , Li Ran , Chen Hao , Chen Ming-Kai , Luan Yu-Xin , Wang Yi , Yu Zhi-Xiang , Ye Mengchun
Published: June 2021

Allylic amines are versatile building blocks in organic synthesis and exist in bioactive compounds, but their synthesis via hydroaminoalkylation of alkynes with amines has been a formidable challenge. Here, we report a late transition metal Ni-catalyzed hydroaminoalkylation of alkynes with N-sulfonyl amines, providing a series of allylic amines in up to 94% yield. Double ligands of N-heterocyclic carbene (IPr) and tricyclohexylphosphine (PCy3) effectively promote the reaction.
Phase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors
Authors: Schneider Marcel A. , Linecker Michael , Fritsch Ralph , Muehlematter Urs J. , Stocker Daniel , Pestalozzi Bernhard , Samaras Panagiotis , Jetter Alexander , Kron Philipp , Petrowsky Henrik , Nicolau Claude , Lehn Jean-Marie , Humar Bostjan , Graf Rolf , Clavien Pierre-Alain , Limani Perparim
Published: June 2021

Hypoxia is prominent in solid tumors and a recognized driver of malignancy. Thus far, targeting tumor hypoxia has remained unsuccessful. Myo-inositol trispyrophosphate (ITPP) is a re-oxygenating compound without apparent toxicity. In preclinical models, ITPP potentiates the efficacy of subsequent chemotherapy through vascular normalization. Here, we report the results of an unrandomized, open-labeled, 3 + 3 dose-escalation phase Ib study (NCT02528526) including 28 patients with advanced primary hepatopancreatobiliary malignancies and liver metastases of colorectal cancer receiving nine 8h-infusions of ITPP over three weeks across eight dose levels (1'866-14'500 mg/m2/dose), followed by standard chemotherapy. Primary objectives are assessment of the safety and tolerability and establishment of the maximum tolerated dose, while secondary objectives include assessment of pharmacokinetics, antitumor activity via radiological evaluation and assessment of circulatory tumor-specific and angiogenic markers. The maximum tolerated dose is 12,390 mg/m2, and ITPP treatment results in 32 treatment-related toxicities (mostly hypercalcemia) that require little or no intervention. 52% of patients have morphological disease stabilization under ITPP monotherapy. Following subsequent chemotherapy, 10% show partial responses while 60% have stable disease. Decreases in angiogenic markers are noted in ∼60% of patients after ITPP and tend to correlate with responses and survival after chemotherapy.
Evolution and expansion of Li concentration gradient during charge–discharge cycling
Authors: Chae Byeong-Gyu , Park Seong Yong , Song Jay Hyok , Lee Eunha , Jeon Woo Sung
Published: June 2021

To improve the performance of Li-ion batteries (LIBs), it is essential to understand the behaviour of Li ions during charge–discharge cycling. However, the analytical techniques for observing the Li ions are limited. Here, we present the complementary use of scanning transmission electron microscopy and atom probe tomography at identical locations to demonstrate that the evolution of the local Li composition and the corresponding structural changes at the atomic scale cause the capacity degradation of Li(Ni0.80Co0.15Mn0.05)O2 (NCM), an LIB cathode. Using these two techniques, we show that a Li concentration gradient evolves during cycling, and the depth of the gradient expands proportionally with the number of cycles. We further suggest that the capacity to accommodate Li ions is determined by the degree of structural disordering. Our findings provide direct evidence of the behaviour of Li ions during cycling and thus the origin of the capacity decay in LIBs.
Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain
Authors: Tan Timothy J. C. , Yuan Meng , Kuzelka Kaylee , Padron Gilberto C. , Beal Jacob R. , Chen Xin , Wang Yiquan , Rivera-Cardona Joel , Zhu Xueyong , Stadtmueller Beth M. , Brooke Christopher B. , Wilson Ian A. , Wu Nicholas C.
Published: June 2021

Since the COVID-19 pandemic onset, the antibody response to SARS-CoV-2 has been extensively characterized. Antibodies to the receptor binding domain (RBD) on the spike protein are frequently encoded by IGHV3-53/3-66 with a short complementarity-determining region (CDR) H3. Germline-encoded sequence motifs in heavy chain CDRs H1 and H2 have a major function, but whether any common motifs are present in CDR H3, which is often critical for binding specificity, is not clear. Here, we identify two public clonotypes of IGHV3-53/3-66 RBD antibodies with a 9-residue CDR H3 that pair with different light chains. Distinct sequence motifs on CDR H3 are present in the two public clonotypes that seem to be related to differential light chain pairing. Additionally, we show that Y58F is a common somatic hypermutation that results in increased binding affinity of IGHV3-53/3-66 RBD antibodies with a short CDR H3. These results advance understanding of the antibody response to SARS-CoV-2.
Breaking the acoustic diffraction limit with an arbitrary shape acoustic magnifying lens
Authors: Abdolali Ali , Barati Sedeh Hooman , Fakheri Mohammad Hosein , Shen Chen , Sun Fei
Published: June 2021

Based on the transformation acoustics methodology, the design principle for achieving an arbitrary shape magnifying lens (ASML) is proposed. Contrary to the previous works, the presented ASML is competent of realizing far-field high resolution images and breaking the diffraction limit, regardless of the position of the utilized sources. Therefore, objects locating within the designed ASML can be properly resolved in the far-field region. It is shown that the obtained material through the theoretical investigations becomes an acoustic null medium (ANM), which has recently gained a significant attention. Besides the homogeneity of ANM, which makes it an implementable material, it is also independent of the perturbation in the geometry of the lens, in such a way that the same ANM can be used for different structural topologies. The obtained ANM has been implemented via acoustics unit cells formed by membranes and side branches with open ends and then was utilized to realize an ASML with the aid of effective medium theory. It is shown that the far-field results of an ideal ASML abide well with the results of the implemented sample, validating the proposed design principle. The presented acoustic magnifying lens has a wide spectrum of possible applications ranging from medical imaging, and biomedical sensors to focused ultrasound surgery.
Comprehensive analysis of bacteriocins in Streptococcus mutans
Authors: Watanabe Atsuko , Kawada-Matsuo Miki , Le Mi Nguyen-Tra , Hisatsune Junzo , Oogai Yuichi , Nakano Yoshio , Nakata Masanobu , Miyawaki Shouichi , Sugai Motoyuki , Komatsuzawa Hitoshi
Published: June 2021

Streptococcus mutans produces bacteriocins that show antibacterial activity against several bacteria. However, comprehensive analysis of these bacteriocins has not been well done. In this study, we isolated 125 S. mutans strains from volunteers and determined their whole genome sequence. Based on the genome analysis, the distribution of each bacteriocin gene (mutacins I-IV, K8 and Smb) was investigated. We found 17, 5, and 2 strains showing 100% matches with mutacin I, mutacin II and mutacin III, respectively. Five mutacin III-positive strains had 2 mismatches compared to mature mutacin III. In 67 mutacin IV-positive strains, 38 strains showed 100% match with mutacin IV, while 29 strains showed some variations. In 23 mutacin K8- and 32 mutacin Smb-positive strains, all except one mutacin K8-positive strain showed 100% match with the mature peptides. Among 125 strains, 84 (65.1%), 26 (20.2%), and 5 (3.9%) strains were positive for one, two and three bacteriocin genes, respectively. Then, the antibacterial activity against oral streptococci and other oral bacterial species was investigated by using bacteriocin gene single-positive strains. Each bacteriocin gene-positive strain showed a different pattern of antibacterial activity. These results speculate that individual S. mutans strains may affect the bacterial composition of dental plaques.
Author Correction: Incidence of notified Lyme borreliosis in Germany, 2013–2017
Authors: Enkelmann Julia , Böhmer Merle , Fingerle Volker , Siffczyk Claudia , Werber Dirk , Littmann Martina , Merbecks Sophie-Susann , Helmeke Carina , Schroeder Sabine , Hell Stefan , Schlotthauer Uwe , Burckhardt Florian , Stark Klaus , Schielke Anika , Wilking Hendrik
Published: June 2021

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Standardization of Raman spectra using variable penalty dynamic time warping
Authors: Xu Qingyu , Chen Hongju , Ye Shaoqing , Zeng Yongming , Lu Hongmei , Zhang Zhimin
Published: June 2021

The RS-VPdtw method can synchronize the nonlinear displacement between spectra acquired with different spectrometers.
A cationic fluorescent probe for highly selective detection of sodium dodecyl sulfate (SDS) by electrostatic and hydrophobic self-assembly
Authors: Chen Hongrui , Mu Xinyue , Li Jian , Qin Yuqi , Yan Liqiang
Published: June 2021

A cationic fluorescent probe for highly selective detection of SDS by electrostatic and hydrophobic self-assembly.
Pollution risk estimation of the Cu element in atmospheric sedimentation samples by laser induced breakdown spectroscopy (LIBS) combined with random forest (RF)
Authors: Feng Ting , Zhang Xin , Li Maogang , Chen Tingting , Jiao Long , Xu Yanyan , Tang Hongsheng , Zhang Tianlong , Li Hua
Published: June 2021

LIBS combined with RF was proposed to estimate the pollution risk of the Cu element in atmospheric sedimentation samples.
A near-infrared fluorescent probe targeting mitochondria for sulfite detection and its application in food and biology
Authors: Chao Jianbin , Wang Zhuo , Zhang Yongbin , Huo Fangjun , Yin Caixia
Published: June 2021

TheNIR-BNprobe exhibited near-infrared emission at 680 nm, which greatly promoted its application in biology. Due to its low detection limit, the probe can be used for the detection of SO32−in food samples, cells and zebrafish.
Structural transformation between rutile and spinel crystal lattices in Ru–Co binary oxide nanotubes: enhanced electron transfer kinetics for the oxygen evolution reaction
Authors: Yu Areum , Kim Myung Hwa , Lee Chongmok , Lee Youngmi
Published: June 2021

A variety of binary RuxCo1−xOy (x = 0.19, 0.33, 0.47, 0.64 and 0.77) were synthesized via electrospinning and subsequent calcination, and investigated for OER electrocatalytic activity in 1.0 M HClO4 aqueous solution.
High lithium storage performance of CoO with a distinctive dual-carbon-confined nanoarchitecture
Authors: Chen Yanbin , Song Jian , Li Yuexian , Tian Qinghua , Chen Jizhang , Yang Li
Published: June 2021

A well-designed nanoarchitecture endowed CoO nanoparticles with outstanding electrochemical kinetics and structural stability.
Multifunctional polyplex micelles for efficient microRNA delivery and accelerated osteogenesis
Authors: Li Qian , Hu Zhiai , Rong Xin , Chang Bei , Liu Xiaohua
Published: June 2021

A multifunctional polyplex micelle PPP-RGI efficiently delivers miR-218 (an osteogenic miRNA regulator) to BMSCs for enhanced osteogenesis.
Using nickel to fold discrete synthetic macromolecules into single-chain nanoparticles
Authors: Reith Melissa A. , Kardas Sinan , Mertens Chiel , Fossépré Mathieu , Surin Mathieu , Steinkoenig Jan , Du Prez Filip E.
Published: June 2021

Sequence-defined macromolecules were prepared with a thiolactone-based platform whereby ligand functionalities were introduced along the backbone enabling a nickel induced formation of single-chain nanoparticles.
DNA-templated control of chirality and efficient energy transport in supramolecular DNA architectures with aggregation-induced emission
Authors: Ucar Hülya , Wagenknecht Hans-Achim
Published: June 2021

DNA architectures with tetraphenylethylene are assembled in a non-covalent way. The strong aggregation-induced emission of the chromophores is quenched and the energy is transported to Atto dyes by a multistep energy “hopping”.
Do efficient small-scale fishers stay active in eras of introducing individual transferable quotas? Evidence from Denmark
Authors: Hoff Ayoe , Nielsen Max , Nielsen Rasmus
Published: June 2021

Theory suggests the use of individual transferable quotas (ITQs) as a solution to overcapacity and to keep efficient fishers active. While the reduction of overcapacity under ITQ implementation is well documented, empirical evidence on the role of capacity utilisation in adjusting the labour force is scarce. This article analyses whether the capacity utilisation of the vessels that fishers own/work on influences their probability of continuing fishing or whether factors such as fishing income and pension are more important. Danish small-scale fisheries with vessels less than 17 m in length, in which ITQs were introduced in 2007, are studied using a multinomial logit regression based on a unique dataset of individual income and socioeconomic characteristics of Danish fishers in the period 2002-2012 as well as individual vessel data. Together with other relevant socioeconomic variables, vessel capacity utilisation is included in the regression. The latter is identified in a productivity analysis of all commercial active vessels using Data Envelopment Analysis. It is found that increasing vessel capacity utilisation both significantly and positively influences the decision to stay in a small-scale fishery. Increasing income from fisheries also significantly influences the probability of staying in the fishery business. The Danish results provide evidence that the most efficient fishers are those who remain active when ITQs are implemented.
Financial Technology: China’s Stock Markets vs U.S. Stock Markets
Authors: Chang Ruiqian
Published: June 2021

This paper provides a detailed analysis of the difference between the Chinese stock market and the U.S. stock market under the development of financial technology. In conclusion, we find that the Chinese stock market is more dominated by retail investors, but the United States owns more stocks, mostly held by institutional investors, and has a better financial mindset. The behavior of investors in the Chinese stock market is mainly the excessive speculation of investors in the Chinese market. This is one of the reasons for the many fluctuations in the Chinese stock market. Due to the speculative nature of China’s stock market, the floating ratio reflects the management mechanism of China’s stock market and helps to observe the correlation with the U.S. stock market. And technology and digitalization affect the trading of the stock market. This research is correlational, and there is no causality implied.
Study on the optimization path of SME financing services in the context of the epidemic
Authors: Gu Weijian , Zhou Rui , Yan Jingwen
Published: June 2021

The status of SMEs in the national economy has become increasingly prominent, but due to the factors like their small scale, imperfect information disclosure, the problem of financing difficulty and high financing has always restricted the health of SMEs in China. This report takes Wuhan as an example, which is the earliest affected by the COVID epidemic, starting from the new financing difficulties and the development of banking business of SMEs in Wuhan under the background of the epidemic, explores the methods to guide the three parties of banks, enterprises and governments to improve services, so as to better play the role of alleviating the new financing pressure of SMEs, and puts forward some suggestions, such as promoting the interaction of government and banks’ information, establishing an efficient punishment mechanism for enterprises’ dishonesty, and strengthening the supervision A series of countermeasures and suggestions, such as accurate product service innovation of fast financial institutions, guiding the docking of supply chain and bill financing platform. These suggestions have important reference significance and practical reference value for better adapting to the new characteristics of financing in the post epidemic era and alleviating the financing pressure of SMEs.
Research on the location of S express logistics terminal delivery network in Haizhou District of Lianyungang
Authors: Wu Xuemei , Xu Yingyun
Published: June 2021

With the development of Internet technology, consumption on the internet has become an indispensable way of consumption in our life, and the logistics industry driven by network consumption is also rising rapidly. Logistics terminal distribution is a kind of logistics activity that logistics service providers deliver express packages directly to consumers from the last distribution network. It is the last link of logistics service to meet the needs of customers. The purpose of this paper is to analyze the distribution of a certain express terminal network in Haizhou District of Lianyungang, put forward the proposal of increasing the distribution network, and study the location of the network through AHP, and determine the final location and the establishment of the network has a certain significance to improve customer satisfaction and other aspects.
Research on the Construction of E-commerce Platform for Poverty Alleviation Products Based on Internet
Authors: Qiao Xinjiang , Ai Weiping , Chen Xuan , Feng Ximing
Published: June 2021

With the development of the current Internet, e-commerce has also shown a vigorous vitality. The development of China’s new poverty alleviation model is also closely related to the Internet e-commerce platform. The construction of e-commerce platform has gradually become an important path to get rid of poverty in rural areas. Through a series of analysis, this paper summarizes some current situation of e-commerce development and some effects achieved by e-commerce platform in poverty alleviation, and summarizes the experience and poverty alleviation model of some domestic e-commerce platforms. Finally, the feasibility of the current agricultural products e-commerce poverty alleviation model is studied and discussed.

Subject: Research on the Reform of Ideological and Political Education for College Students in Jiangxi Province in 2020
Research of Dual-channel Supply Chain Decision with Consideration of Low-carbon and Fairness Concerns
Authors: Niu Guoshuai , Wei Qi
Published: June 2021

With in-depth implementation of policies on energy conservation and emission reduction and rising of low-carbon production practice in enterprises, low-carbon supply chain has gradually become a research issue which causes extensive attentions from scholars. However, most existing researches focus on supply chain decision and coordination under the background of single channel or mere consideration of fairness concerns of retailers. Therefore, the fairness concerns of manufacturers were taken into account in the double-channel low-carbon supply chain. A double-channel low-carbon supply chain model was constructed to research the influence of manufacturers’ fairness concerns to the optimal decision-making of all parties in the supply chain and to the overall performance of supply chain. The research results suggested that: with improvement of manufacturers’ fairness concern coefficient, the decision-making of supply chain members demonstrated different changing strength; the manufacturers’ fairness concern caused harm to overall profit of supply chain.
Inclusive Financing’s Development and Urban-rural Income Gap—Empirical analysis based on provincial panel data
Authors: Xu Jing , Sun Mingyue , Wang Hening
Published: June 2021

With the further development of China’s economy, the income of urban and rural residents has increased. At present, China’s economy has changed from a stage of high-speed growth to a stage of high-quality development. However, uneven and insufficient regional development is still a problem that requires great attention. Inclusive Financing’s development provides residents with more access to financial services and is one of the important ways to build a well-off society and develop the economy in recent years. Based on the Peking University Digital Inclusive Financing Index, this paper studies the relationship between the development level of Inclusive Financing and the income gap between urban and rural residents by constructing panel data of 31 provinces, cities and regions in China and establishing a model for empirical analysis. The study found that the development of Inclusive Financing has a significant impact on the income gap between urban and rural areas, among which the improvement of the level of Inclusive Financing in the economically developed eastern region has a very obvious effect on narrowing the income gap between urban and rural areas. However, blindly developing Inclusive Financing in the underdeveloped central and western regions will also cause the further widening of the income gap between urban and rural areas. The conclusion of this paper has certain positive significance for narrowing the income gap between urban and rural areas and promoting the development of Inclusive Financing.
The Practice of Political Online Teaching of Wireless Sensor Network Course based on ZIGBEE
Authors: Shu Xiangyang
Published: June 2021

ZIGBEE technology is based on mature communication standards, and its technology application field is more and more extensive, such as intelligent home appliances, medical health, military reconnaissance, environmental monitoring and other aspects have great development space. With the development of science and technology, information technology, represented by multimedia and network technology, has been widely used in education field. The use of information technology has attracted more and more attention of teachers and students. But the current situation is not ideal for the deep integration of information technology and political teaching. The purpose of this paper is to study the application of wireless sensor network in the political online classroom, to increase the integration of information technology and political education, and to improve the interest of students in political learning. This paper, through the relevant theoretical research, considers the application of WLAN in political classroom, analyzes its advantages and makes teaching process. The shortcomings of traditional wireless sensor network are analyzed and the optimization algorithm is proposed to save energy. In the environment of wireless sensor network deployment, an online teaching platform is built. This paper uses SSH framework technology to realize the functions of the system, and gives the specific introduction of the realization of each function module in the system. Through the system debugging, deployment and implementation, the system successfully completed the course deployment and implementation, which strongly supports the smooth progress of the flipped classroom teaching reform. Finally, through questionnaire and interview, teachers and students have a good attitude towards online teaching platform, the highest satisfaction of the system stability is 100%, 86.67% of the teachers are satisfied with the ease of use of the system operation.
Study on Factors Influencing Consumption Potential of Female College Students’
Authors: Luo Shisi , Li Chenggang
Published: June 2021

Under the background of supply-side structural reform and the concept of sustainable development, the clothing rental market cannot be ignored, and its market consumption potential is still promising. Enterprises should improve the hygienic quality of rental clothing, broaden the types of clothing supply and increase the economic source of female college students to fully tap the consumption potential of rental clothing market among female college students. In order to open the market, it is essential to conform to the trend of digital economy and sharing economy in the new era, and promote the green and sustainable development of the clothing industry.
Perioperative Medizin in der Viszeralchirurgie beim alten Patienten aus anästhesiologischer Perspektive
Authors: Söhle Martin , Coburn Mark
Published: June 2021

Der demografische Wandel führt zu einer zunehmenden Anzahl alter Patienten sowohl in unserer Gesellschaft als auch im Krankenhaus. Mit zunehmendem Alter steigt nicht nur die Anzahl der Vorerkrankungen, sondern auch die postoperative Komplikationsrate und Mortalität. Letztlich ist aber nicht das Alter ausschlaggebend, sondern der Zustand des Patienten und seine Kapazität, sich den körperlichen und mentalen Herausforderungen eines operativen Eingriffs zu stellen. Besonders von Komplikationen bedroht sind gebrechliche Patienten und eine wesentliche – als Prähabilitation – bezeichnete Strategie besteht darin, diese durch körperliches und mentales Training sowie Ernährungsberatung bereits präoperativ in einen besseren Zustand zu versetzen. Das Delir gehört zu den häufigsten postoperativen Komplikationen. Maßnahmen, wie der Verzicht auf eine Prämedikation mit Benzodiazepinen, die Messung der Narkosetiefe, der Verzicht auf langwirksame Opioide, die Durchführung von Fast-Track
Surgery sowie die zügige postoperative Bereitstellung von Brille/Hörgerät können das Delirrisiko reduzieren. Eine enge interdisziplinäre Absprache zwischen Chirurgen, Anästhesisten, Geriatern und Physiotherapeuten ist wesentlich, um das perioperative Vorgehen miteinander abzustimmen und das perioperative Risiko für alte Patienten zu reduzieren.
A Step Toward Optimizing Regenerative Medicine Principle to Combat COVID-19
Authors: Sharma Shilpa , Jeyaraman Madhan , Muthu Sathish , Anudeep Talagavadi Channaiah , Jeyaraman Naveen , Shringeri Ajay Satish , Kumar Vinodh , Somasundaram Rajeswari , Jain Rashmi , Jha Saurabh Kumar
Published: June 2021

Drugs are currently not licensed in specific to pulverize COVID-19. On an emergency basis, vaccines were approved to prevent the further spread of COVID-19. This serves as a potential background for considering the optimization of biologics. In this context, evidence on convalescent plasma and stem cells has shown a beneficial role. Here, we have considered this as plausible therapy, and further hypothesize that their cocktails will synergistically boost the immunogenicity to relegate COVID-19. This warrants a large volume clinical trial on an emergent basis, because the sooner we establish a safe and effective cure, the better.
Free online chlamydia and gonorrhoea urine test request in Queensland, Australia: convenience of home sample collection versus pathology collection centre attendance for faster results
Authors: Groos Anita , Peardon-Freeman Shelley , McFarlane Kim , Braithwaite Simone , Gajjar Deepa , Murch Pamela , Spucches Catherine
Published: June 2021

Background A free online chlamydia and gonorrhoea urine testing service (Webtest) is available for people living in Queensland, Australia. There are two options to provide a urine sample: at a pathology collection centre or by using a home mailing kit. The study aimed to trial these two testing options designed for young people and describe which is the preferred testing choice. Methods: Data for online requests made from 3 August 2017 to 31 December 2019 provides information for age, gender, location of clients, results received, treatment and partner notification reported by people with positive results. Results: For 29 months, there were 4642 Webtest requests and 2906 valid results received. For young people (16–29 years), chlamydia positivity was 8.2% (172/2105; 95% CI, 7.1–9.4) versus 3.2% (26/801; 95% CI, 2.2–4.7) for people aged ≥30 years, and 6.8% (198/2906; 95% CI, 6.0–7.8) for all ages. Home mailing kits were the most popular testing choice, with 68.0% (1977/2906) of results received from urine submitted by post and 32.0% (929/2906) via pathology collection centre. Conclusions: The free online test request service engaged young people at risk of sexually transmissible infections and found home sample collection was most popular.
An Italian Hotel’s Partnership with the WWF, the World Wildlife and Nature Conservation Charity
Authors: Lods Aurélie , Louis Oriane , Quemener Margot , Sanjivy Agnès
Published: June 2021

Oasy Hotel is set in a protected natural area and welcomes guests looking to reconnect with nature and wide open spaces. The hotel operates according to principles of sustainability, serving organic food from its own farms and offering activities that raise awareness of environmental issues. The hotel is referenced in the Regenerative Travel directory as the first social and ecological sustainable resort in Italy, and the third in Europe. The Covid-19 pandemic has been a challenge but also represents an opportunity, due to a heightened interest in nature-based experiences (
Alina-Cerasela and Daniel, 2020
).

Information

Written on the basis of material provided by Matteo Pennacchi and Andrea Manes of the Oasy Hotel, in the context of Skema’s Strategic Marketing Projects programme.

© CAB International 2021
Analytical Hierarchy Process to Assess the Supply Chain Risk for Improving Sustainability of Shallot Agribusiness in Low Land Area
Authors: Suhaeni  , Andayani Sri Ayu
Published: June 2021

Shallots are one of the potential horticultural commodities, but they face various risks that affect the performance of the supply chain for shallot agribusiness. To reduce potential risks, it is necessary to identify various types of risks with a priority scale. This study is to analyse various risks in supply chain flows and the involvement of various actors in shallot agribusiness in Majalengka Regency in the lowlands. The research was conducted using a descriptive survey method and data collection of 50 respondents through interviews and questionnaires. The collected data were analysed using the Analytical Hierarchy Process (AHP) model. The results showed that the risks that occurred in the lowlands were production risk (15.6%), price risk (14.2%), market risk (10.9%), environmental risk (8.7%), and distribution risk. (8.6%). The actors involved consist of farmers, farmer groups, traders, middlemen, retailers, and consumers. The results of this study can emphasize to facilitate decision making in risk mitigation by paying attention to the priority scale.
Rain Detection using Himawari-8 Imagery; Case Study Singkawang West Kalimantan
Authors: Dharma C S , Trilaksono N J
Published: June 2021

The occurrence of convective activity often appears in a localized area and short duration. The formation of a low cloud might give an insight into the formation of bigger cumulus that can be seen as a Convective Initiation (CI) and if constantly developing it may lead to a bigger cloud with extreme rainfall. Detection of convective activity that leads to extreme rainfall is important to people who live near shore and areas that prone to flood. Himawari-8 imagery and data from an automatic weather station in Singkawang, West Kalimantan, was applied to detect short time, low-intensity rainfall that had been observed in the equator, near shore, during midnight and early morning. The appearance of CI was analyzed using rapid cloud-top cooling based on Himawari-8 imagery. It was found that the observed rainfall was in agreement with the cloud formations. Those data were validated by three days of a rain event with maximum cumulative rain of 30 mm observed in a single day. There was also appeared a small low cloud that grows into a bigger cloud above the observed area.
Characteristics and Depositional Processes of Coastal and Marine Sediments of The Northern Part of Obi Island, Molucca
Authors: Zuraida R , Adhirana I , Lattuputty G , Hernawan U , Gustiantini L , Hasanah I , Alam M , Prasetyo F B
Published: June 2021

This paper presents the characteristics of coastal and marine sediments of the northern part of Obi Island, Molucca. Grain size analyses were conducted on 24 coastal sediment and 32 marine sediment samples. Taphonomy of Homotrema rubrum was studied on three samples from coral reef that grows on the slope off Laiwui to determine current direction. The mean grain size ranges between 0.01 – 2.6 mm, very well sorted to very poorly sorted, and while skewness varies from very finely skewed to very coarsely skewed. While lithic fragments predominate coastal sediments, biogenic fragments form the majority of marine sediment grains. Textural parameters and sediment composition show three distinctive groups that represent: 1) Akeleletango in the west that is characterized by moderately sorted coarse to fine sand; 2) Tabuji – Laiwui that is characterized by poor to moderately sorted fine granules to fine sand that is interpreted as debris flow deposit; and 3) Anggai in the east that is characterized by poorly sorted coarse sand. Linear discriminate function analysis shows the dominance of shallow marine deposits in beach sediments with strong fluvial influence. The taphonomy of H. rubrum indicates that the prevailing current direction off Obi is westward, which is supported by current observation.
Approaching SWOT Analysis to Develop Strategies of Marine-Ecotourism in Bedono Village, Sayung, Demak
Authors: Rezagama A , Setyati W A , Agustini T W , Sunaryo  , Devi S A , Deswanto E , Budiati I M
Published: June 2021

Climate change and abrasion have had a wide impact in various regions of the world. In the area of Central Java Province, such as the coast of Semarang-Demak, there has been a significant change from being an agrarian society to become a coastal area. This raises the potential for coastal disaster-based ecotourism. However, there are many challenges that need to be assessed first to provide a basis for the development direction. Ecotourism provides direct benefits for nature and community conservation in the context of revitalizing resources to rebuild socio-economic conditions that have not been properly managed. The purpose of this study is to examine the development of Disaster-Marine-Ecotourism using a SWOT analysis. The application of SWOT analysis in maritime tourism planning in Bedono village found some specific and unique points. The biggest challenge are developing the competence of local leaders in the tourism sector and improving tourism support infrastructure. Meanwhile, the biggest threat from outside is environmental conditions which are getting worse every year. So synergy from various parties, especially the government, is needed in providing disaster response programs in the area.
Application of Nano Organic Materials in Agriculture farming and yield analysis for Groundnut crop with comparison to conventional inorganic farming
Authors: Patel Anant
Published: June 2021

Agriculture is the primary source of income for the majority of India’s people. Big farmers in India use inorganic fertilisers and pesticides on their plantations. However, it would reduce soil fertility. So, in order to address this problem, this paper encourages farmers to return to organic farming, while still increasing crop yield and decreasing crop water requirements. Nano materials and different bio fertilizers were used to cultivate the groundnut crop. For this, we applied these fertilisers to one acre of land for crop production, whereas on the other hand, we applied simple organic fertilisers and water to another one acre of land for comparison. The key goal is to increase yield with high-quality groundnuts. The use of these Nano organic products results in a 17-20% increase in overall production, and the cost-benefit ratio is 1.98, which is very good as compared to conventional inorganic farming.
Synthesis of Metal Complex for Photocatalytic Degradation of Dyes under Visible Light Irradiation
Authors: Kumar Hemant , Kaur Amandeep
Published: June 2021

In the present work, Schiff base ligand has been synthesized from synthesized dialdehyde and primary amine. The synthesized ligand and its copper metal complex were characterized by melting point & spectral analysis such as IR, 1HNMR, 13C and GC-MS. In the presence of H2O2 as an oxidising agent the photocatalytic performance of the complex was assessed by the photodegradation of dyes. By carrying spectrophotometrically on irradiation of visible light using Cu(II) metal complex of Schiff base ligand the photocatalytic degradation of Naphthol Blue Black dye (NBB), Rhodamine B (RB) and Methylene Blue (MB) dyes was carried out. The photocatalytic degradation of NBB, RB and MB dyes was carried out with reference to effect of time. The results revealed that Cu-complex of Schiff base ligand is consistent for photocatalysis of these dyes for treatment of authentic effluents. The results show that the optimal dose for maximal degradation of these dyes was found to be 5 mgL-1 of the Cu(II) metal complex. The % degradation of NBB, RB and MB were found to be 55%, 50% and 80% in the visible light irradiation. The % degradation of MB dye was greater as compare to other two dyes. The order of % degradation of three dyes by copper metal complex was found as MB > NBB >RB
Cubic surfaces of characteristic two
Authors: Kadyrsizova Zhibek , Kenkel Jennifer , Page Janet , Singh Jyoti , Smith Karen , Vraciu Adela , Witt Emily
Published: June 2021

Cubic surfaces in characteristic two are investigated from the point of view of prime characteristic commutative algebra. In particular, we prove that the non-Frobenius split cubic surfaces form a linear subspace of codimension four in the 19-dimensional space of all cubics, and that up to projective equivalence, there are finitely many non-Frobenius split cubic surfaces. We explicitly describe defining equations for each and characterize them as extremal in terms of configurations of lines on them. In particular, a (possibly singular) cubic surface in characteristic two fails to be Frobenius split if and only if no three lines on it form a “triangle”.
Social media as tool for the Church’s mission and response to the COVID-19 pandemic
Authors: Galang Justine Renus F , Galang Joseph Renus F
Published: June 2021

A recent correspondence claimed that the establishment of community pantries across the Philippines embodies a spirituality of “Alay Kapwa” as it connects people, especially in a time of crisis such as the 2019 coronavirus (COVID-19) pandemic, to be persons for others. 1 This article highlights that the rise of community pantries was primarily aided by social media. It claims that if social media is utilized ethically and with positive disposition and perspective, it can be a powerful tool in the Church’s mission of evangelization, and in its response to this pandemic.
Fatty acid compartmentalization
Authors: Coleman Rosalind
Published: June 2021

Before long‐chain fatty acids can be oxidized or used to synthesize complex lipids, they must be activated by one of the acyl‐CoA synthetase (ACSL) family members. Our data in liver, heart, and skeletal muscle has suggested that each activating ACSL isoform can direct fatty acids towards or away from specific downstream pathways. Because we hypothesized that directionality must occur via specific protein interactions, we used the protein interaction discovery technique, BioID, to determine interacting protein partners and function. We targeted ACSL isoform‐1 either to the ER or to the outer mitochondrial membrane (OMM) of Hepa1–6 cells as a fusion protein with the modified E.coli biotin ligase, BirA*. In the presence of added biotin, BirA irreversibly biotinylates proteins that are in close proximity to the ACSL1 bait. Mass spectrometry identified 98 proteins that interacted only with the ER‐targeted ACSL1, 55 proteins that interacted only with the OMM‐targeted ACSL1, and 43 proteins that interacted with both targeted ACSL1 constructs. We selected a subset of lipid droplet and vesicle proteins for confirmation by co‐immunoprecipitation and functional studies. At the OMM, ACSL1 interacted with lipid droplet tethering proteins in a glucose‐dependent manner. At the ER, ACSL1 interacted with proteins involved in ceramide synthesis and with ER and peroxisomal proteins involved in peroxisomal oxidation of niche fatty acids. Thus, we have captured a novel snapshot of key proteins that may influence ACSL1 function and determine downstream partitioning of acyl‐CoAs.

Support or Funding Information

DK56598, DK59935

This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.