bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the climate change impact on water availability and the links between water pollution and economy for sustainable water resource management in Kaski District, Nepal
Authors: Chapagain Saroj Kumar , Aryal Anil , Mohan Geetha , Shrestha Sadhana , Mishra Binaya Kumar , Fukushi Kensuke
Published: July 2022

The newly enacted national water policy is envisioned as ensuring water sustainability in Nepal. Despite theoretical pertinence, questions remain about the effective implementation due to limited studies on key aspects of sustainability, such as water supply and demand, pollution, and impacts of climate change and socio-economic growth. This study analyses the current and future availability of water under climate change scenarios and determines water resources carrying capacity (WRCC) as the maximum socio-economic growth that can be supported in a case study on the Kaski District, Nepal. Annual average water availability was estimated to be 11,030.7 million cubic meters (MCM) for the baseline period (1992–2010), and 7,677.4 and 7,674.2 MCM for the future period (2022–2050) under the representative concentration pathway (RCP) 4.5 and 8.5 emission scenarios, respectively. For the baseline period, WRCC far exceeds the current population; therefore, water resources will not be a limiting factor for local socio-economic development. Nevertheless, sustainable water infrastructure development policies are necessary to ensure a reliable water supply able to cope with increasing seasonal variability and declining future water availability. A total of 30,049 tons of biological oxygen demand (BOD) loads were estimated based on the economic activities of the Kaski District in 2011, with the direct and indirect sectoral roles of water pollution determined for the first time. Rather than a single pollution control strategy based on pollution loads, multiple sector-specific strategies are necessary to effectively implement water pollution control policies.
Potentially pathogenic Escherichia coli from household water in peri-urban Ibadan, Nigeria
Authors: Rabiu Akeem Ganiyu , Falodun Olutayo Israel , Fagade Obasola Ezekiel , Dada Rotimi Ayodeji , Okeke Iruka N.
Published: July 2022

Feco-orally transmitted infectious diseases are common in Nigeria where the potable water access is poor. In the south-western Nigerian Ibadan metropolis, supply of municipal water is meagre as residents depend on household wells and boreholes. The likelihood of fecal contamination of household water sources in Ibadan was examined longitudinally to quantify and understand its impact. Well and borehole water samples aseptically collected from 96 households in Ibadan were assessed for total heterotrophic counts (THCs), total coliform counts (TCCs) and total Escherichia coli counts (TECs) using a pour plate technique. E. coli were identified by uidA and whole-genome sequencing using Illumina technology, whereas virulence factors were predicted using VirulenceFinder. There was season-independent abundance of THC and TCC in the well and borehole with a significant recovery of E. coli in the wells during the wet season compared to the dry season (P = 0.0001). Virulence genes associated with pathogenic E. coli were identified in 13 (52%) strains with one E. coli each classified as extra-intestinal E. coli, avian pathogenic E. coli and enteroaggregative E. coli. High heterotrophic and coliform counts, with rainfall-driven E. coli contamination revealed that the water sources evaluated in this study are unfit for consumption.
Razvitie meditsinskogo turizma v Indii: poslednee desiatiletie
Authors: Kumar Abhijit
Published: July 2022

Medical tourism in India promises a bright spot for multiple reasons both from the side of the arriving patients as well as from the supply side. It has multiple modes of treatment which are availed by the incoming patients from Ayurveda to Buddhist to Herbal medicinal treatments. In terms of pharmaceutical cost and availability as well, India fares better than many countries which are seen especially in generic medicines that India is known for and which have brought India both friendship as well as hostility from countries. The post-COVID world is starkly new in terms of the medical world. It has radically altered how we perceive the medical field and the world around it. India's medical tourism is no exception as it faces challenges in contemporary times. This paper studies the development of medical tourism in India in the previous decade. The study provides an overview of medical tourism in India and the reasons for the country becoming one of the popular choices for patients from abroad.
ABOVE-GROUND NET PRIMARY PRODUCTIVITY AND RAIN USE EFFICIENCY OF Megathyrsus maximus PASTORAL SYSTEMS: CASE STUDY OF EL 14 ESTABLISHMENT, DEPARTAMENTO MORENO, SANTIAGO DEL ESTERO, ARGENTINA
Authors: Tiedemann Jose Luis
Published: July 2022

The objectives of this work were: to delimit the growing seasons of the M. maximus pastoral systems in El 14 establishment, Departamento Moreno, Santiago del Estero, Argentina, in the 2000-2021 period using time series of NDVIMODIS and threshold 0.5 NDVIRATIO; to quantify their aboveground net primary productivity (ANPP) and their responses to seasonal rainfall anomalies; to quantify the rain use efficiency (RUE), relate it to seasonal rainfall and determine its trend in the period. Growing seasons (GS) start in November and end in May. Significant differences were found in the ANPP of GS with anomalies positive and negative of seasonal rainfall. ANPP recovers after GS with negative rainfall anomalies, evidencing their resilience capacity after extreme weather events. The RUE had a high negative trend in the period. Significant differences were found in the RUE and seasonal rainfall. Most of RUE are related to the normal range of rainfall for the study area. In turn, growing season with lowest RUE were related to rainfall ≥ 700 mm. Seasonal rainfall of 700 mm could be considered the threshold in the loss of water of pastoral systems. Anthropic activities like deforestation and livestock, added to shifts in seasonal storm in intensity/magnitude, number of rainy, timing and frequency, they would contribute to the loss of large amounts of water by surface runoff in the study area. The local information obtained enables the implementation of appropriate management strategies in order to mitigate extreme climatic adversities.
Multifunctional Concrete Technology
Authors: Naiqian Feng
Published: July 2022

The book reviews production and applications of high- and ultrahigh strength multifunctional concrete. The use of various coarse and fine aggregates are covered, as well as ultrafine powders, new superplasticizers, anti-rust agents for steel bars and electrochemical protection technology.
Challenges and opportunities for utilizing MSME digital marketing applications in tourism areas
Authors: Ramdan Andry Mochamad , Pramiarsih Euis Eka , Herdhiana Ria , Zahara Rita , Lisnawati Cucu
Published: July 2022

Talking about the challenges of running a business in this competitive era is a fact. Likewise, running a tourism-supporting MSME business in Indonesia has challenges and opportunities. This study aims to obtain scientific evidence and discuss it to answer the challenges and opportunities MSME drivers face when adopting digital-based marketing in their business in the tourism sector. Through a study of many literature sources that we obtained electronically, several publications, both books, and scientific articles, we finally got the results of this research. As for the analysis process, we use techniques such as coding, analyzing and evaluating the data thoroughly, and extracting conclusions that can answer this problem with high validity. Based on the study's results and data discussion, we can say that MSME managers still face challenges in adopting digital applications in their tourism sector business. The main challenge is handling technology and promotional efforts with the ability to master foreign languages ??and competitive marketing strategies. Meanwhile, the opportunity is that with the application of this technology, MSME actors can get innovative, creative, and profitable services so that the Indonesian tourism industry can be more easily developed.
Technology-based HR management to optimize MSME product and service marketing
Authors: Endrawati Titin , Sutjiatmo Bayu Prabowo , Murti Aji Kresno , Widodo Anung , Nawiyah Nawiyah
Published: July 2022

Technology-based human capital management, such as digital applications, is part of efforts to maximize the marketing of small business products and services. It discusses the management of science and technology-based marketing innovations that need to be encouraged. This study discusses the role of human resource management and its advantages in the technology sector to support the development of small business marketing so that people's businesses can continue to be sustainable and support the increase in the country's foreign exchange. This study also analyzes the data on the drivers of MSMEs based on technology innovation that we collect from various scientific reports and technology studies from various application contexts in the field. We collect data electronically from several scientific publications in the form of books and other literature, which we analyze with a phenomenological approach to get valid findings. We propose a technology-laden HR management model for business people, especially the marketing of small business products in Indonesia, transitioning from traditional marketing to innovative strategies that can be continuously supported. The results of this analysis will later assist in studying marketing innovation updates for small business products and services in future HR studies and training.
The Effect of Klika Ongkea Extract (Mezzetia parviflora Becc.) on Pancreatic β-Cells Regeneration by Streptozotocin-Induced in Wistar Rats
Authors:   Faculty of Pharmacy, University of Megarezky, Makassar, South Sulawesi, Jangga Jangga , Mansur Mansur ,   Faculty of Pharmacy, University of Megarezky, Makassar, South Sulawesi, Latu Saparuddin ,   Faculty of Pharmacy, University of Megarezky, Makassar, South Sulawesi
Published: July 2022

This study aimed to determine the effect of Klika ongkea (Mezzetia parviflora Becc.) extract on the regeneration of pancreatic β-cells on Wistar rats that were induced using streptozotocin. Streptozotocin (STZ) with a 40 mg/kg BW dose was used in this study. Eighty adult male Wistar rats were used for this study. The animals were divided into four groups, Group I, as a healthy controls; Group II as an STZ-induced, Group III, STZ-induced and treated with galvus (Vildagliptin) 0.9 mg/200 g BW; Group IV, STZ-induced and treated with Klika ongkea 100 mg/kg BW. This study was conducted for 28 days. Four animals each group on the 1st, 7th, 14th, 21st and 28th days were observed to analyze the number of pancreatic β-cells. On the last day, pancreases were isolated and stained with hematoxylin & eosin (H&E) to analyze the regeneration of pancreatic β-cells. The data analysis was performed using an Independent-Sample T-Test to compare the number of pancreatic β-cells. The results showed that the administration of Klika ongkea extracts affected the pancreatic β-cells regeneration. These findings suggest that Klika ongkea has an effect on the regeneration of pancreatic β-cells in streptozotocin-induced rats.
The main stages of the formation and development of the sanitary and epidemiological service in the country and the contribution of Rospotrebnadzor bodies and organizations in the Rostov region to the common cause (to the 100th anniversary of the Sanitary and Epidemiological Service of the Russian federation)
Authors: Kovalev E. V. , Karpushchenko G. V. , Noskov A. K. , Tverdokhlebova T. I. , Shchipeleva I. A. , Chemisova O. S. , Markovskaya E. I. , Kretenchuk O. F. , Korshenko V. A. , Aleksakhina N. V. , Agafonova V. V.
Published: July 2022

Objective:formation of a brief overview of data on the main historical stages of the formation and development of the sanitary and epidemiological service in the country as a whole and in the Don region, in particular, as well as on the contribution of Rospotrebnadzor bodies and organizations in the Rostov region to the common cause of ensuring the sanitary and epidemiological well-being of the country in different time periods.Materials and methods:Analysis of archival materials, library collections of institutes and literary sources from databases of electronic libraries e-library, CyberLeninka, etc.Results:The contribution of the Rostov-on-Don Research Anti-Plague Institute and the Rostov Research Institute of Microbiology and Parasitology to the common cause of ensuring the sanitary and epidemiological well-being of the country in different time periods is indicated. Special attention is paid to the issues of effective interaction of Rospotrebnadzor bodies and organizations among themselves and with other healthcare and scientific institutions.Conclusion:Russia has developed a very efficient, operational system capable of effectively addressing issues of ensuring the sanitary and epidemiological well-being of the population.
Usability and Effectiveness of an Individualized, Tablet-Based, Multidomain Exercise Program for People With Dementia Delivered by Nursing Assistants: Protocol for an Evaluation of the InCoPE-App
Authors: Barisch-Fritz Bettina , Bezold Jelena , Scharpf Andrea , Trautwein Sandra , Krell-Roesch Janina , Woll Alexander
Published: July 2022

Background

The COVID-19 pandemic has had drastic consequences on everyday life in nursing homes. Limited personnel resources and modified hygiene and safety measures (eg, no external exercise instructors, no group settings) have often led to interrupted physical exercise treatments. As a consequence, people with dementia benefiting from individualized exercise programs are affected by the pandemic’s impact.

Objective

Our goal is to develop an easily applicable mobile application (Individualized Cognitive and Physical Exercise [InCoPE] app) allowing nursing assistants to test cognitive function and physical performance and subsequently train people with dementia through a multidomain, individualized exercise program.

Methods

We will evaluate the usability and effectiveness of the InCoPE-App by applying a mixed method design. Nursing assistants will use the InCoPE-App for 18 weeks to assess the cognitive function and physical performance of 44 people with dementia every 3 weeks and apply the individualized exercise program. We will record overall usability using questionnaires (eg, Post-Study System Usability and ISONORM 9241/10), log events, and interviews. Perceived hedonic and pragmatic quality will be assessed using the AttrakDiff questionnaire. Effectiveness will be evaluated by considering changes in quality of life as well as cognitive function and physical performance between before and after the program.

Results

Enrollment into the study will be completed in the first half of 2022. We expect an improvement in the quality of life of people with dementia accompanied by improvements in cognitive function and physical performance. The usability of the InCoPE-App is expected to be rated well by nursing assistants.

Conclusions

To date, there is no scientifically evaluated app available that enables nursing assistants without expertise in sports science to deliver an individualized exercise program among people with dementia. A highly usable and effective InCoPE-App allows nursing assistants to test cognitive function and physical performance of people with dementia and, based thereon, select and deliver an appropriate individualized exercise program based on the cognitive and physical status of an individual, even in times of a pandemic.

Trial Registration

German Register of Clinical Trials DRKS00024069; https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00024069

International Registered Report Identifier (IRRID)

DERR1-10.2196/36247
Perspectives on Ethical Issues Around the Use of Smartphone Apps for HIV Prevention in Malaysia: Focus Group Study With Men Who Have Sex With Men (Preprint)
Authors: Khati Antoine , Shrestha Roman , Rosen Aviana , Luces Jeffrey , Wickersham Jeffrey , Azwa Iskandar , Ab Halim Mohd Akbar
Published: July 2022

BACKGROUND

The use of smartphone apps can improve the HIV prevention cascade for key populations such as men who have sex with men (MSM). In Malaysia, where stigma and discrimination toward MSM are high, app-based strategies have the potential to open new frontiers for HIV prevention efforts. However, little guidance is available to inform researchers about ethical concerns unique to the development and implementation of app-based HIV prevention programs.

OBJECTIVE

This study aims to understand and characterize the attitudes and concerns of Malaysian MSM regarding HIV prevention mobile apps, particularly focusing on ethical aspects surrounding their use.

METHODS

We conducted online focus group discussions with 23 MSM between August and September 2021. Using in-depth semistructured interviews, participants were asked about their perceived risks, benefits, and ethical issues associated with using mobile apps for HIV prevention. Each session was digitally recorded and transcribed. Transcripts were inductively coded using Dedoose software and analyzed to identify and interpret emerging themes.

RESULTS

Overall, participants indicated a preference for using app-based strategies for HIV prevention efforts. Emerging themes on benefits related to app use for HIV prevention included convenience, anonymity (ability to remain anonymous while seeking care), less stigmatizing access to services (ability to avoid the burden and stigma of visiting an HIV clinic in person), readily accessible multimedia resources (eg, text, graphics, videos), and self-management portals (eg, medication adherence, appointment reminders). Prominent concerns raised by participants included privacy and confidentiality concerns, issues around personal health data storage and management, and fear of the Malaysian government accessing data.

CONCLUSIONS

The findings from this study indicate that app-based strategies for HIV prevention efforts are acceptable among Malaysian MSM. The results further highlighted the role of ethical concerns and the associated risks and benefits related to the use of app-based HIV prevention programs. Given the ever-evolving nature of such technological platforms and the complex ethical and legal landscape, such platforms must be safe and secure to ensure widespread public trust and uptake.
Development and Usability Testing of a Chatbot to Promote Mental Health Services Use Among Individuals With Eating Disorders Following Screening (Preprint)
Authors: Shah Jilllian , DePietro Bianca , D'Adamo Laura , Firebaugh Marie-Laure , Laing Olivia , Fowler Lauren A , Smolar Lauren , Sadeh-Sharvit Shiri , Taylor Craig Barr , Wilfley Denise E , Fitzsimmons-Craft Ellen E
Published: July 2022

BACKGROUND

Eating disorders (EDs) are complex mental illnesses with debilitating, pervasive psychological and physiological consequences when left untreated. Unfortunately, patients may face barriers to receiving treatment, such as stereotypes surrounding EDs, denial of illness severity, lack of motivation for treatment, and lack of knowledge about treatment resources. Barriers such as these result in a large treatment gap: only 20% of those with EDs will ever receive treatment. Digital tools like chatbots show potential to disseminate mental health–related interventions to large populations while offering a user-friendly, cost-effective, accessible, and anonymous means of tackling patient concerns.

OBJECTIVE

This study developed and evaluated the usability of a chatbot designed for pairing with online ED screening. The tool aimed to promote mental health service utilization by improving motivation for treatment and self-efficacy among individuals with EDs.

METHODS

A chatbot prototype, Alex, was designed using decision trees and theoretically informed components: psychoeducation, motivational interviewing, personalized recommendations, and repeated administration. Usability testing was conducted over 4 iterative cycles, with user feedback informing refinements to the next iteration. Postintervention, participants (N=21) completed the System Usability Scale (SUS), the Usefulness, Satisfaction, and Ease of Use Questionnaire (USE), and a semistructured interview. This process aimed to create an optimized chatbot by the final cycle for use in a randomized trial.

RESULTS

Interview feedback detailed chatbot aspects participants enjoyed and aspects necessitating improvement. Feedback converged on four themes: user experience, chatbot qualities, chatbot content, and ease of use. Following refinements, users described Alex as humanlike, supportive, and encouraging. Content was perceived as novel and personally relevant. USE scores across domains were generally above average (~5 out of 7), and SUS scores indicated “good” to “excellent” usability across cycles, with the final iteration receiving the highest average SUS score.

CONCLUSIONS

Overall, participants responded well in interactions with Alex, including the initial version. Refinements between cycles further improved user experiences. This study provides preliminary evidence of the feasibility and acceptance of a chatbot designed to promote motivation for and use of services among individuals with EDs. Alex is the first chatbot designed for pairing with an ED or other mental health–related online screen, with the goal of ultimately increasing service utilization.
Clinical Outcomes in Vaccinated and Unvaccinated COVID-19 Inpatient Admissions March to September 2021: A Single Center Retrospective Cohort Analysis (Preprint)
Authors: Bakali-Khan Kashmala , Grace-Abraham Nadine , Chen-Joea Cynthia , Velez-Dalla Tor Maili , LaScala Nena , Ronquillo Denise
Published: July 2022

BACKGROUND

Background: COVID-19 is an international public health emergency. In the United States, vaccination rates remain modest. Vaccine-mediated immunity is unlikely in the face of emerging variants and surging cases in vaccinated patients give pause to consider the underlying cause.

OBJECTIVE

To shed light on how COVID effects the public health, especially in an underserved community. Despite development of promising vaccines, surges in COVID cases gives pause to consider affects on age, gender, comorbidities, length of stay, intensive care unit admission, mechanical ventilation, as well as waning immunity

METHODS

Methods: Retrospective cohort analysis of Emanate Health hospital system from March - September 2021. Demographic and clinical factors for adult inpatient COVID-19 admissions were analyzed using Meditech software. These included age, gender, comorbidities, date of admission, and immunization status. Immunization status was confirmed via the California Immunization Registry.

RESULTS

Results: Of 475 COVID+ admissions, 28% were vaccinated. Admissions decreased from March to June, but steeply increased from June to August, driven predominately by unvaccinated patients. Length of stay (LOS) was higher for patients 60-79 years and with four and six comorbidities. Mortality was 1.5 times higher in patients 60-79 years and 1.3 times higher in patients with four and six comorbidities. Incompletely vaccinated patients were more likely to require ICU admission and ventilation, causing increased mortality.

CONCLUSIONS

Conclusions: Poor outcomes in unvaccinated, older patients and those with comorbidities corroborate national data. Among fully vaccinated, LOS did not vary significantly by vaccine type. Mortality increased with age, peaking at 60-79 years. Hypertension, diabetes mellitus, and obesity conferred higher admission and mortality in vaccinated patients, elaborating foci for risk assessment. Our data builds on existing research, demonstrating the protective effects of vaccination, which may decrease vaccine hesitancy. Administration of a booster may be needed earlier than previous federal guidelines recommended to combat waning immunity.
Correction: Assessing the Efficacy of an Individualized Psychological Flexibility Skills Training Intervention App for Medical Student Burnout and Well-being: Protocol for a Randomized Controlled Trial (Preprint)
Authors: Ditton Elizabeth , Knott Brendon , Hodyl Nicolette , Horton Graeme , Walker Frederick Rohan , Nilsson Michael
Published: July 2022

UNSTRUCTURED

This is a corrigendum for MS 32992.
Skin of Color Representation Trends in JAAD Case Reports 2015-2021: Content Analysis (Preprint)
Authors: Marroquin Nathaniel A , Carboni Alexa , Zueger Morgan , Szeto Mindy D , Kirk Jessica , Wu Jieying , Ajmal Hamza , Dellavalle Robert P
Published: July 2022

UNSTRUCTURED

—
The Association of Telehealth Availability and Quality of Care Measures for Patients With Diabetes at Federally Qualified Health Centers: Retrospective Cohort Study (Preprint)
Authors: Cole Megan B , Jones Nicholas , Lee Eun Kyung , Kim June-Ho
Published: July 2022

UNSTRUCTURED
Prevention of Unplanned Hospital Admissions in Multimorbid Patients Using Computational Modeling: Observational Retrospective Cohort Study (Preprint)
Authors: González-Colom Rubèn , Herranz Carmen , Vela Emili , Monterde David , Contel Joan Carles , Sisó-Almirall Antoni , Piera-Jiménez Jordi , Roca Josep , Cano Isaac
Published: July 2022

BACKGROUND

Enhanced management of multimorbidity constitutes a major clinical challenge. Multimorbidity shows well-established causal relationships with the high use of health care resources and, specifically, with unplanned hospital admissions. Enhanced patient stratification is vital for achieving effectiveness through personalized postdischarge service selection.

OBJECTIVE

The study has a 2-fold aim: (1) generation and assessment of predictive models of mortality and readmission at 90 days after discharge; and (2) characterization of patients’ profiles for personalized service selection purposes.

METHODS

Gradient boosting techniques were used to generate predictive models based on multisource data (registries, clinical/functional and social support) from 761 nonsurgical patients admitted in a tertiary hospital over 12 months (October 2017 to November 2018). K-means clustering was used to characterize patient profiles.

RESULTS

Performance (area under the receiver operating characteristic curve, sensitivity, and specificity) of the predictive models was 0.82, 0.78, and 0.70 and 0.72, 0.70, and 0.63 for mortality and readmissions, respectively. A total of 4 patients’ profiles were identified. In brief, the reference patients (cluster 1; 281/761, 36.9%), 53.7% (151/281) men and mean age of 71 (SD 16) years, showed 3.6% (10/281) mortality and 15.7% (44/281) readmissions at 90 days following discharge. The unhealthy lifestyle habit profile (cluster 2; 179/761, 23.5%) predominantly comprised males (137/179, 76.5%) with similar age, mean 70 (SD 13) years, but showed slightly higher mortality (10/179, 5.6%) and markedly higher readmission rate (49/179, 27.4%). Patients in the frailty profile (cluster 3; 152/761, 19.9%) were older (mean 81 years, SD 13 years) and predominantly female (63/152, 41.4%, males). They showed medical complexity with a high level of social vulnerability and the highest mortality rate (23/152, 15.1%), but with a similar hospitalization rate (39/152, 25.7%) compared with cluster 2. Finally, the medical complexity profile (cluster 4; 149/761, 19.6%), mean age 83 (SD 9) years, 55.7% (83/149) males, showed the highest clinical complexity resulting in 12.8% (19/149) mortality and the highest readmission rate (56/149, 37.6%).

CONCLUSIONS

The results indicated the potential to predict mortality and morbidity-related adverse events leading to unplanned hospital readmissions. The resulting patient profiles fostered recommendations for personalized service selection with the capacity for value generation.
Clinical Efficacy of Nutritional Supplements in Atopic Dermatitis: Systematic Review (Preprint)
Authors: Weber Isaac , Woolhiser Emily , Keime Noah , Wasvary Margaret , Adelman Madeline J , Sivesind Torunn E , Dellavalle Robert P
Published: July 2022

BACKGROUND

Atopic dermatitis (AD), also known as eczema, is a chronic inflammatory skin condition that presents with symptoms of intense pruritus, dryness, and erythema. Dissatisfaction with first-line therapies for AD, the desire to avoid steroids, and the extreme cost of effective biologics have created a demand for alternative treatment options such as oral vitamins and nutritional supplements.

OBJECTIVE

The purpose of this review was to assess the effectiveness of oral nutritional supplements, pre- and probiotics, and vitamin deficiencies and supplements on AD symptomology and clinical course.

METHODS

We searched Scopus, PubMed, and MEDLINE (Ovid interface) for English-language articles published between 1993 and 2023. The final search was conducted on June 22, 2023. The search terms comprised the following: “(Atopic Dermatitis or Atopic Eczema) AND (supplement OR vitamin OR mineral OR micronutrients OR Fish Oil OR Omega Fatty Acid OR Probiotics OR Prebiotics OR apple cider vinegar OR collagen OR herbal OR fiber).”

RESULTS

A total of 18 studies—3 (17%) evaluating vitamins, 4 (22%) evaluating herbal medicine compounds, 2 (11%) evaluating single-ingredient nutritional supplements, and 9 (50%) evaluating pre- and probiotics—involving 881 patients were included in this review.

CONCLUSIONS

Overall, there is weak evidence to support any one nutritional supplement intervention for the alleviation of AD symptoms. Multiple trials (4/18, 22%) showed promise for supplements such as Zemaphyte, kefir, and freeze-dried whey with Cuscuta campestris Yuncker extract. The most evidence was found on the effectiveness of probiotics on the clinical course of AD. Lactiplantibacillus plantarum, Ligilactobacillus salivarius, and Lactobacillus acidophilus specifically showed evidence of efficacy and safety across multiple studies (6/18, 33%). However, larger, more extensive randomized controlled trials are needed to determine the true effectiveness of these supplements on the broader population.

CLINICALTRIAL

PROSPERO CRD42023470596; https://tinyurl.com/4a9477u7
Design Features Associated With Engagement in Mobile Health Physical Activity Interventions Among Youth: Systematic Review of Qualitative and Quantitative Studies (Preprint)
Authors: Schwarz Ayla , Winkens Laura H H , de Vet Emely , Ossendrijver Dian , Bouwsema Kirsten , Simons Monique
Published: July 2022

BACKGROUND

Globally, 81% of youth do not meet the physical activity (PA) guidelines. Youth of families with a low socioeconomic position are less likely to meet the recommended PA guidelines. Mobile health (mHealth) interventions are preferred by youth over traditional in-person approaches and are in line with their media preferences. Despite the promise of mHealth interventions in promoting PA, a common challenge is to engage users in the long term or effectively. Earlier reviews highlighted the association of different design features (eg, notifications and rewards) with engagement among adults. However, little is known about which design features are important for increasing engagement among youth.

OBJECTIVE

To inform the design process of future mHealth tools, it is important to investigate the design features that can yield effective user engagement. This systematic review aimed to identify which design features are associated with engagement in mHealth PA interventions among youth who were aged between 4 and 18 years.

METHODS

A systematic search was conducted in EBSCOhost (MEDLINE, APA PsycINFO, and Psychology & Behavioral Sciences Collection) and Scopus. Qualitative and quantitative studies were included if they documented design features associated with engagement. Design features and related behavior change techniques and engagement measures were extracted. Study quality was assessed according to the Mixed Method Assessment Tool, and one-third of all screening and data extraction were double coded by a second reviewer.

RESULTS

Studies (n=21) showed that various features were associated with engagement, such as a clear interface, rewards, multiplayer game mode, social interaction, variety of challenges with personalized difficulty level, self-monitoring, and variety of customization options among others, including self-set goals, personalized feedback, progress, and a narrative. In contrast, various features need to be carefully considered while designing mHealth PA interventions, such as sounds, competition, instructions, notifications, virtual maps, or self-monitoring, facilitated by manual input. In addition, technical functionality can be considered as a prerequisite for engagement. Research addressing youth from low socioeconomic position families is very limited with regard to engagement in mHealth apps.

CONCLUSIONS

Mismatches between different design features in terms of target group, study design, and content translation from behavior change techniques to design features are highlighted and set up in a design guideline and future research agenda.

CLINICALTRIAL

PROSPERO CRD42021254989; https://tinyurl.com/5n6ppz24
Examining Mental Workload Relating to Digital Health Technologies in Health Care: A Systematic Review focusing on Assessment Methods (Preprint)
Authors: Kremer Lisanne , Lipprandt Myriam , Röhrig Rainer , Breil Bernhard
Published: July 2022

BACKGROUND

The workload in healthcare is steadily increasing – healthcare professionals (HCP) report stress and a very demanding environment. As a result, mental health issues are on the rise among HCP, the proneness to errors in tasks could increase. The digitization of patient care is intended to counteract processes of demographic change, that could be in relation to high stress levels. It remains unclear whether the Health Information System(s) (HIS) and digital health technologies (DHT) used, relieve the professionals or even represent a further burden. The mental construct that describes this burden of technologies is Mental Workload (MWL).
Work in the clinic can be viewed as working in safety-critical environments: Particularly in this sensitive setting, the measurement methods of MWL are relevant - mainly due to their strongly differing intrusiveness and sensitivity. The method of eye tracking could provide a useful way to measure MWL directly in the field.

OBJECTIVE

The systematic review addresses two different, but related objectives.
1. In which manner do DHT contribute to the overall MWL of health care workers: which aspects or factors of DHT contribute to an increase of MWL?
2. Which methods/ assessments are applied to measure MWL related to HIS/ Digital Technologies?
2.1. Which role does Eye tracking/ Pupillometry play in context of measure?
2.2. Which outcomes are being assessed via eye tracking?

METHODS

Following the PRISMA statement, we conducted a systematic review. Based on the research questions, we defined keywords that were combined to search terms. The review followed the following steps: literature search, article selection, data extraction, risk of bias assessment, data analysis and data synthesis.

RESULTS

The literature search process resulted in 25 included studies that have studied the resulting MWL of healthcare workers from using DHT in health care settings.
The main results can be grouped by two categories: assessment methods and factors of DHT contributing to MWL. A major part of the studies applied subjective methods for the assessment of MWL (Most applied method: NASA TLX). Eye tracking didn’t play a relevant role. The factors contributing to a higher MWL were clustered by organizational and system factors.

CONCLUSIONS

Our review of 25 papers shows a diverse assessment approach of MWL related to DHT of HCPs as well as two groups of relevant contributing factors to MWL
Although methodological biases were identified, we promote further research concentrating on adequate assessments for relevant settings. We also like to promote the evaluation of quality criteria.

CLINICALTRIAL

PROSPERO registration: CRD42021233271; https://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42021233271&ID=CRD42021233271
Protocol: JMIR Res Protoc 2021;10(8): e29126; https://doi.org/10.2196/29126
Impacts of covid-19 social distancing on the sleep of health students
Authors: Fiorentin Luciano , Cordeiro Marcos Freitas , Cetolin Sirlei Favero , Marmitt Luana Patrícia , Beltrame Vilma
Published: July 2022

Introduction: Sleep plays an important role in the balance of the human body. Its deprivation influences the development of cardiovascular, metabolic, psychological, and learning disorders. The restrictions imposed by Covid-19 on social activities affected the routine of many people, including university students, possibly impacting sleep conditions. Objective: To analyze the sleep characteristics of university students in the health area during the Covid-19 social distancing. Methodology: Cross-sectional study with 656 students from two community universities of Santa Catarina. Behavior characteristics were analyzed before and during the pandemic, relating them to sleep. Proportion analysis, crude and adjusted analyzes of the factors associated with sleep problems were performed. Results: 48.8% of the students had sleep problems. Of these, 41% were developed during social distancing. There was an increase in the difficulty to start sleep (42.4%), to stay asleep (29.4%), and dissatisfaction with sleep (36.6%). Sleep time was adequate, but insufficient to feel good for 25.6%. More sleep problems were observed among students that were older (PR=1.17; CI95%: 0.76-1.80), studied at UNOESC (PR=1.87; CI95%: 1.12-3.14), had greater use of social media (PR=2.03; CI95%: 1.21-3.39), had anxiety, sadness, and concern (PR=1.78; CI95%:1.02-3.10), had worse eating habits (PR=1.45; CI95: 1.01-2.07) and consumed alcohol (PR=1.59; IC95%: 0.98-2.58). Conclusion: Proper sleep time did not guarantee satisfaction with sleep. The prevalence of students with sleep problems increased with social distancing. Unhealthy eating habits, alcohol consumption, and social media use increased the risk of these problems.
Políticas públicas, estatalidades e experimentações neoliberalizantes: o estado do Rio de Janeiro como um caso situado
Authors: Oliveira Fábio Lucas Pimentel de , Brandão Carlos Antônio , Werner Deborah
Published: July 2022

O artigo busca situar as políticas públicas e os desafios de constituir ações estatais e estatalidades de outra natureza no contexto dos processos de neoliberalização recentes e/ou em curso na América Latina. Procura identificar os determinantes estruturais e averiguar os modos pelos quais tais processos impactam as capacidades governativas. Utilizando o estado do Rio de Janeiro como um estudo de caso situado, realiza-se um exame das implicações socioeconômicas e institucionais do processo de neoliberalização, nas circunstâncias estruturais e conjunturais da crise profunda e multidimensional pela qual passa a sociedade fluminense. São apontadas diversas restrições à execução de uma agenda inclusiva e durável de desenvolvimento no território estadual, que tem sido cada vez mais submetido às lógicas pró-mercado. Por isso, é discutida a necessidade de reconstituir, em novas bases, estatalidades portadoras de valores emancipatórios.
Molecular Docking, Synthesis, Characterization, and Preliminary Cytotoxic evaluation of new 1, 3, 4-Thiadiazole Derivatives as Αlpha-Estrogen Receptor Modulator
Authors: M. Abdulkhaleq Zainab , Hassan Mohammed Mohammed , Suhail Wadi Jaafar
Published: July 2022

Objective: This study concluded that these newly synthesized analogs may be represented as an exploitable source of new anticancer agents to fight breast cancer

Methods: Using The crystal structure of Human α Estrogen Receptor (α-ER) with a 4-HYDROXYTAMOXIFEN(standard) as a co-crystalized ligand was gained from the protein data-bank (PDB code 3ERT) as a result of docking the 1,3,4-thiadiazole derivatives compounds(M1-M3) give good docking scores compared to the standard. Compounds M1-M3 was synthesized by multistep procedures from the reaction of intermediate (benzyloxy)phenyl)-1,3,4-thiadiazole-2(3H)-thione derivatives (D1, D2) and the 4-bromo-1-(cyclic amine1-yl)butan-1-one derivatives intermediate (A1, A2). The chemical structures of the target compounds and their intermediates were confirmed by FT-IR, 1H NMR, and 13C NMR.

Results: The in-vitro cytotoxicity assay (MTT assay) demonstrated that compounds M1-M3 showed good inhibition ratios in Breast cancer cell line (MCF-7) comparable with drug control Tamoxifen

Conclusion: From the docking study, it was concluded that piperidine and methyl-piperazine moiety were very successful to bind tightly to alpha estrogen receptors by making numerous interaction modes.
Implementasi protokol kesehatan pada tatanan kehidupan era baru terhadap usaha perjalanan wisata di bali
Authors: Lumanauw Nelsye , Sumartana I Made
Published: July 2022

Pandemi Covid-19 telah berdampak pada berbagai lini kehidupan, termasuk sektor pariwisata. Adanya pembatalan perjalanan oleh wisatawan, pembatasan pergerakan sosial dan larangan bepergian oleh berbagai wilayah dunia, mengakibatkan terpuruknya usaha perjalanan wisata. Berbagai upaya pemulihan pariwisata Bali dilakukan pemerintah, salah satunya kepemilikan sertifikat tatanan kehidupan era baru, sebagai jaminan keamanan dan kepercayaan bagi wisatawan. Kurangnya pemahaman terhadap tatanan kehidupan era baru, tampak pada masih sedikitnya perusahaan yang memiliki sertifikat tersebut. Kriteria tatanan kehidupan era baru dan implementasinya merupakan tujuan penelitian ini. Penelitian ini menggunakan metode analisis deskriptif kualitatif untuk menganalisis data implementasi protokol tatanan kehidupan era baru pada 25 usaha perjalanan wisata. Teori verifikasi dan sertifikasi digunakan untuk memperjelas ruang lingkup masalah yang diteliti. Kesimpulan penelitian ini adalah implementasi tatanan kehidupan era baru belum sepenuhnya dilaksanakan oleh usaha perjalanan wisata di Bali.  Komitmen menerapkan protokol kesehatan menjadi kunci utama bagi wisatawan mancanegara mengunjungi destinasi wisata Bali memasuki era tatanan kehidupan baru.
Late Bronze and Pre-Roman Iron Age Bronze Rings – Jewellery or Ingots?
Authors:   University of Latvia, Vasks Andrejs
Published: July 2022

Among the bronze items dating to Latvia’s Late Bronze Age (1100–500 BC) and the Pre-Roman Iron Age (500–1 BC) there are rings with open ends that resemble bracelets or necklaces by size. The number of bronze rings and their fragments is not large – 57 units, but that of fragments of casting moulds is much higher – 856. The article deals with the data of both these rings and the respective castings. The main focus is on the problem of the function of these rings: whether they were ingots or jewellery. The author argues that, although bronze rings were used as jewellery, it was probably not their only or even their main function. Bronze rings were used for more convenient storing and transporting of metal, but also as a value equivalent in exchange operations.
Development and Evaluation of Self Micro Emulsifying Drug Delivery System (SMEDDS) for Nebivolol Hydrochloride
Authors: Ramya Sri Sura  , Subrahmanyam CVS  , Shyam Sunder Rachamalla
Published: July 2022

The  present  investigation  aimed  to  prepare  a  self  micro  emulsifying  drug  delivery  system  (SMEDDS)  for  the dissolution enhancement of nebivolol hydrochloride.  The main objective of this work was to develop, characterize, and evaluate a solid SMEDDS prepared by using the adsorption technique of a liquid SMEDDS to improve the solubility and dissolution rate of nebivolol hydrochloride.   The excipients were chosen based on the high solubility of nebivolol hydrochloride, and their concentrations were optimized by constructing ternary phase diagrams.   Thirty-two combinations were prepared using oil (Labrafac Lipophile WL 1349), surfactant (Kolliphor RH 40), and co-surfactant (Gelucire 44/14).  Self-emulsification time, dilution studies, and thermodynamic stability studies were satisfactory.   The in vitro nebivolol release profile showed a faster rate of dissolution compared with the pure nebivolol hydrochloride suspension and marketed formulation.  The droplet size was in the range  of  132.8±22.1  to  955.7±15.5  nm  and  zeta  potential  in  the  range  -7.2±0.53  mV  to  -46.4±0.32  mV  for  the  selected formulations.  Formulation N17 (Labrafac Lipophile WL 1349 -10%w/w, Kolliphor RH40-72%w/w, Gelucire 44/14- 18%w/w) was considered as optimized formulation and showed drug release of 97.26 ± 1.16% in 0.1 N HCl in 120 minutes, the particle size of 132.8±22.1 nm and zeta potential of -46.4±0.32 mV.   Thus, the present studies ratify that the bioavailability was improved by nebivolol  SMEDDS  formulation.    The  optimized  liquid  SMEDDS  was  further  used  for  the  preparation  of  Solid  SMEDDS (S-SMEDDS) formulations by using adsorption carriers.   The optimized Solid SMEDDS formulation exhibited 95.38 ± 0.76% in vitro drug releases, which was significantly higher than that of the drug solution.  The optimized formulation of nebivolol-loaded S-SMEDDS exhibited complete in vitro drug release in 120 min as a compared pure drug solution.  The present result confirmed the potential use of SMEDDS to improve the dissolution and oral bioavailability of poorly water-soluble nebivolol.
Designing Health Data Portability Under Korean Law
Authors:   Journal of Law research, Lee Won-Bok , Bae Hyun-A
Published: July 2022

Two bills have recently been proposed at the Korean National Assembly to introduce data portability provisions to the Personal Information Protection Act. The two bills were largely modeled on Article 20 Right to Data Portability of European Union’s General Data Protection Regulation (“GDPR”).
We argue that the proposed “one-size-fits-all” provisions are ill-suited to health data portability for a few reasons. First and foremost, the bills stop short of mandating interoperability of data being transferred, in a manner similar to the GDPR. Unlike in some other sectors, however, interoperability is critical in achieving ease of data transmission in health care, because health IT is highly fragmented with numerous vendors, each with their own data format. Secondly, the two bills exempt inferred data and derived data from data portability, also in a manner similar to the GDPR. While such exemption may be striking a balance between the interest of individuals and the interest of data controllers, it renders data portability almost valueless in the context of health care, where important data are usually inferred data and derived data created by health providers. Lastly, an exemption from data portability for small businesses will be at odds with health care, in which primary care clinics are inevitably “small businesses”. These limitations found in the data portability bills are not surprising, in light of the core objective of their model, Article 20 of the GDPR, which was to promote competition by helping users retrieve their data held by dominant service providers.
Hence, we argue that a better approach to health data portability is to amend the Medical Service Act that already includes basic measures to facilitate data exchange between health providers. Although the Medical Service Act too has to be amended to implement health data portability in the scale already being implemented in other countries, it will not be limited by the need for universal applicability across different industries that the general, Personal Information Protection Act faces. Instead, more nuanced and sophisticated health data portability can be designed in the Medical Service Act that provides more clarity to complex legal issues unique to health data, such as interoperability, data scope, health information exchange and secondary use, to name a few.