bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the Effects of Ninjin’yoeito on Physical Frailty in Mice
Authors: Otsuka Shotaro , Fukumaru Keita , Tani Akira , Takada Seiya , Kikuchi Kiyoshi , Norimatsu Kosuke , Matsuzaki Ryoma , Matsuoka Teruki , Sakakima Harutoshi , Omiya Yuji , Mizuno Keita , Matsubara Yosuke , Maruyama Ikuro
Published: September 2022

Physical frailty is an aging-related clinical syndrome involving decreases in body weight, mobility, activity, and walking speed that occurs in individuals with sarcopenia and is accelerated by increased oxidative stress. Ninjin’yoeito, a traditional Japanese Kampo medicine, is used for treating conditions, including anemia and physical weakness. Here, we investigated whether ninjin’yoeito could improve physical frailty by controlling oxidative stress in the senescence-accelerated mouse prone 8 (SAMP8) model. First, SAMP8 mice were divided into two groups, ninjin’yoeito treated and untreated, with the former consuming a diet containing 3% ninjin’yoeito from 3 months of age. At 7 months of age, body weight, motor function, locomotor activity, and mean walking speed were measured. Subsequently, mice were euthanized and measured for muscle weight, 8-hydroxy-2′-deoxyguanosine levels in muscle and brain, and cleaved caspase-3 expression in brain. The results showed reductions in weight, locomotor function, locomotion, and average walking speed in the untreated group, which were significantly improved by ninjin’yoeito. Furthermore, 8-hydroxy-2′-deoxyguanosine levels were reduced in muscle and brain from ninjin’yoeito-treated mice, compared with the levels in untreated mice; cleaved caspase-3 expression was similarly reduced in brain from the treated mice, indicating reduced apoptosis. Our findings suggest that ninjin’yoeito inhibits sarcopenia-based physical frailty through its antioxidant effects.
Newborn Screening for Duchenne Muscular Dystrophy: First Year Results of a Population-Based Pilot
Authors: Hartnett Michael J. , Lloyd-Puryear Michele A. , Tavakoli Norma P. , Wynn Julia , Koval-Burt Carrie L. , Gruber Dorota , Trotter Tracy , Caggana Michele , Chung Wendy K. , Armstrong Niki , Brower Amy M.
Published: September 2022

Advancements in therapies for Duchenne muscular dystrophy (DMD) have made diagnosis within the newborn period a high priority. We undertook a consortia approach to advance DMD newborn screening in the United States. This manuscript describes the formation of the Duchenne Newborn Screening Consortium, the development of the pilot protocols, data collection tools including parent surveys, and findings from the first year of a two-year pilot. The DMD pilot design is population-based recruitment of infants born in New York State. Data tools were developed to document the analytical and clinical validity of DMD NBS, capture parental attitudes, and collect longitudinal health information for diagnosed newborns. Data visualizations were updated monthly to inform the consortium on enrollment. After 12 months, 15,754 newborns were screened for DMD by the New York State Newborn Screening (NYS NBS) Program. One hundred and forty screened infants had borderline screening results, and sixteen infants were referred for molecular testing. Three male infants were diagnosed with dystrophinopathy. Data from the first year of a two-year NBS pilot for DMD demonstrate the feasibility of NBS for DMD. The consortia approach was found to be a useful model, and the Newborn Screening Translational Research Network’s data tools played a key role in describing the NBS pilot findings and engaging stakeholders.
Heteroleptic Zn(II)–Pentaiodobenzoate Complexes: Structures and Features of Halogen–Halogen Non-Covalent Interactions in Solid State
Authors: Bondarenko Mikhail A. , Novikov Alexander S. , Sokolov Maxim N. , Adonin Sergey A.
Published: September 2022

Reactions between Zn(II) nitrate, pentaiodobenzoic acid (HPIBA) and different pyridines in dimethylformamide (DMF) result in the formation of the heteroleptic neutral complexes [Zn(3,5-MePy)2PIBA2] (1) and [Zn(DMF)3(NO3)PIBA] (2). Both compounds were isolated in pure form, as shown by the PXRD data. The features of specific non-covalent interactions involving halogen atoms (halogen bonding) were examined by means of DFT calculations (QTAIM analysis and the estimation of corresponding energies).
Genetic Variants of CITED2 Gene Promoter in Human Atrial Septal Defects: Case-Control Study and Cellular Functional Verification
Authors: Chen Zhuo , Chen Huan-Xin , Hou Hai-Tao , Yin Xiu-Yun , Yang Qin , Han Jun , He Guo-Wei
Published: September 2022

Atrial septal defect (ASD) is one of the most common forms of congenital heart disease (CHD). Genetic variants in the coding region of the CITED2 gene are known to be significantly correlated with CHD, but the role of variants in the promoter region of CITED2 is unknown. We investigated variants in the promoter of the CITED2 gene in 625 subjects (332 ASD and 293 healthy controls) through Sanger sequencing. Four variants in the CITED2 gene promoter were found only in eight ASD patients with zero occurrence in the control subjects (one case of g.4078A>C(rs1165649373), one case of g.4240C>A(rs1235857801), four cases of g.4935C>T(rs111470468), two cases of g.5027C>T(rs112831934)). Cellular functional analysis showed that these four variants significantly changed the transcriptional activity of the CITED2 gene promoter in HEK-293 and HL-1 cells. Electrophoretic mobility change assay results and JASPAR database analysis demonstrated that these variants created or destroyed a series of possible transcription factor binding sites, resulting in changes in the expression of CITED2 protein. We conclude that the variants of CITED2 promoter in ASD patients affect the transcriptional activity and are likely involved in the occurrence and development of ASD. These findings provide new perspectives on the pathogenesis and potential therapeutic insights of ASD.
Oral Care for Children with Special Healthcare Needs in Dentistry: A Literature Review
Authors: Alamri Hamdan
Published: September 2022

Oral health is a very important aspect of general health, especially for vulnerable groups such as children with special healthcare needs. It is important to provide appropriate oral care in order to promote quality of life and good health for everyone, especially for children with special healthcare needs. Method: We reviewed the recent literature to collect knowledge regarding the delivery of quality oral care to children with special healthcare needs. We also explored some of the treatment management options that could address the needs of these children when attending dental clinics. Result: Unfortunately, we noted significant inequalities with issues related to oral health among those children. This situation often results in limitations to the activities of daily living for these children. There is therefore a need for much-needed advancements and refinements in oral healthcare to address the needs of children who have special healthcare needs. Conclusions: Providing children with special healthcare needs with high-quality dental care may necessitate active liaisons with healthcare facilitators and will require work across professions to make certain that these children’s oral health is also prioritized. Coordinated efforts by dental professionals are needed to provide dental health education and preventive interventions for these children.
The Utility of Video Recording in Assessing Bariatric Surgery Complications
Authors: Nedelcu Marius , Carandina Sergio , Noel Patrick , Mercoli Henry-Alexis , Danan Marc , Zulian Viola , Nedelcu Anamaria , Vilallonga Ramon
Published: September 2022

Introduction: Recording every procedure could diminish the postoperative complication rates in bariatric surgery. The aim of our study was to evaluate the correlation between recording every bariatric surgery and their postoperative analysis in relation to the early or late postoperative complications. Methods: Seven hundred fifteen patients who underwent a bariatric procedure between January 2018 and December 2019 were included in a retrospective analysis. There were: 589 laparoscopic sleeve gastrectomies (LSGs); 110 Roux-en-Y bypasses (RYGBs) and 16 gastric bands (LAGBs). The video recording was systematically used, and all patients were enrolled in the IFSO registry. Results: There were 15 patients (2.1%) with surgical postoperative complications: 5 leaks, 8 hemorrhages and 2 stenosis. Most complications were consequent to LSG, except for two, which occurred after RYGB. In four cases a site of active bleeding was identified. After reviewing the video, in three cases the site was correlated with an event which occurred during the initial procedure. Three out of five cases of leak following sleeve were treated purely endoscopically, and no potential correlated mechanism was identified. Two other possible benefits were observed: a better evaluation of the gastric pouch for the treatment of the ulcer post bypass and the review of one per operative incident. Two negative diagnostic laparoscopies were performed. The benefit of the systematic video recording was singled out in eight cases. All the other cases were completed by laparoscopy with no conversion. Conclusion: To record every bariatric procedure could help in understanding the mechanism of certain complications, especially when the analysis is performed within the team. Still, recording the procedure did not prevent the negative diagnostic laparoscopy, but it could play a significant role for the medico-legal aspect in the future.
Determinants of Cause-Specific Mortality and Loss of Independence in Older Patients following Hospitalization for COVID-19: The GeroCovid Outcomes Study
Authors: Okoye Chukwuma , Calsolaro Valeria , Calabrese Alessia Maria , Zotti Sonia , Fedecostante Massimiliano , Volpato Stefano , Fumagalli Stefano , Cherubini Antonio , Antonelli Incalzi Raffaele , Monzani Fabio
Published: September 2022

Hospitalization for acute SARS-CoV-2 infection confers an almost five-fold higher risk of post-discharge, all-cause mortality compared to controls from the general population. A negative impact on the functional autonomy of older patients, especially in cases of severe disease and prolonged hospitalization, has been recently described. However, little is known about the determinants of cause-specific mortality and loss of independence (LOI) in the activities of daily living (ADL) following COVID-19 hospitalization. Thus, the current prospective, multicenter study is aimed at identifying the determinants of post-discharge cause-specific mortality and the loss of autonomy in at least one ADL function. Older patients hospitalized for a SARS-CoV-2 infection were consecutively enrolled in an e-Registry from 1 March 2020, until 31 December 2020. After at least six months from discharge, patients were extensively re-evaluated according to a common protocol at the outpatient clinic of eight tertiary care Italian hospitals. Of 193 patients [109 (56.4%) men, mean age 79.9 ± 9.1 years], 43 (22.3%) died during follow-up. The most common causes of death were cardiovascular diseases (46.0%), respiratory failure (26.5%), and gastrointestinal and genitourinary diseases (8.8% each). Pre-morbid ADLs qualified as an independent mortality risk factor [adjusted HR 0.77 (95%CI: 0.63–0.95)]. Of 132 patients, 28 (21.2%) lost their independence in at least one ADL. The adjusted risk of LOI declined with a lower frailty degree [aOR 0.03 (95%CI: 0.01–0.32)]. In conclusion, at long-term follow-up after hospitalization for acute SARS-CoV-2 infection, more than 40% of older patients died or experienced a loss of functional independence compared to their pre-morbid condition. Given its high prevalence, the loss of functional independence after hospitalization for COVID-19 could be reasonably included among the features of the “Long COVID-19 syndrome” of older patients.
Risk Stratification for Pacemaker Implantation after Transcatheter Aortic Valve Implantation in Patients with Right Bundle Branch Block
Authors: Schoechlin Simon , Eichenlaub Martin , Müller-Edenborn Björn , Neumann Franz-Josef , Arentz Thomas , Westermann Dirk , Jadidi Amir
Published: September 2022

Background: Permanent pacemaker implantation (PPI) after transcatheter valve implantation (TAVI) is a common complication. Pre-existing right bundle branch block (RBBB) is a strong risk factor for PPI after TAVI. However, a patient-specific approach for risk stratification in this subgroup has not yet been established. Methods: We investigated TAVI patients with pre-existing RBBB to stratify risk factors for PPI and 1-year-mortality by detailed analysis of ECG data, RBBB morphology and degree of calcification in the implantation area assessed by computed tomography angiography. Results: Between 2010 and 2018, 2129 patients underwent TAVI at our institution. Among these, 98 pacemaker-naïve patients with pre-existing RBBB underwent a TAVI procedure. PPI, because of relevant conduction disturbances (CD), was necessary in 43 (43.9%) patients. PPI was more frequently indicated in women vs. men (62.1% vs. 32.8%, p = 0.004) and in men treated with a self-expandable vs. a balloon-expandable valve (58.3% vs. 26.5%, p = 0.035). ECG data (heart rhythm, PQ, QRS, QT) and RBBB morphology had no influence on PPI rate, whereas risk for PPI increased with the degree of calcification in the left septal His-/left bundle branch-area to a 9.375-fold odds for the 3rd tertile of calcification (1.639–53.621; p = 0.012). Overall, 1-year-mortality was comparable among patients with or without PPI (14.0% vs. 16.4%; p = 0.697). Conclusions: Patients with RBBB undergoing TAVI have a high risk of PPI. Among this subgroup, female patients, male patients treated with self-expandable valve types, patients with high load/degree of non-coronary LVOT calcification and patients with atrial fibrillation need enhanced surveillance for CD after procedure.
The Association of Low Skeletal Muscle Mass with Complex Distal Radius Fracture
Authors: Oh Chi-Hoon , Kim Junhyun , Kim Junhan , Yoon Siyeong , Jung Younghoon , Lee Hyun Il , Choi Junwon , Lee Soonchul , Han Soo-Hong
Published: September 2022

Objectives: Sarcopenia is a skeletal muscle loss disease with adverse outcomes, including falls, mortality, and cardiovascular disease (CVD) in older patients. Distal radius fractures (DRF), common in older people, are strongly related to falls. We aimed to investigate the correlation between DRF and low skeletal muscle mass, which strongly correlated to sarcopenia. Methods: We performed a retrospective review of data from patients diagnosed with or without DRF in our institute between 2015 and 2020. Finally, after propensity score matching, data from 115 patients with and 115 patients without DRF were used for analyses. Multivariate logistic regression analysis was performed for sex, body mass index (BMI), the presence of low skeletal muscle mass, bone quality measured by dual-energy X-ray absorptiometry (DXA), and comorbidities (diabetes mellitus, CVD). Results: We found that female sex (odds ratio = 3.435, p = 0.015), CVD (odds ratio = 5.431, p < 0.001) and low skeletal muscle mass (odds ratio = 8.062, p = 0.001) were significant predictors for DRF. BMI and osteoporosis were not statistically significantly related to DRF. Conclusions: Women with low skeletal muscle mass and CVD may be more responsible for DRF than osteoporosis.
The Clinical Characteristics of Pheochromocytomas and Paragangliomas with Negative Catecholamines
Authors: Zhao Lin , Zhang Xiaoran , Meng Xu , Zhang Ting , Fan Hua , Zhang Qiongyu , Liu Yecheng , Zhou Xianliang , Zhu Huadong
Published: September 2022

Pheochromocytomas and paragangliomas (PPGLs) associated with negative catecholamines are not uncommon. However, few studies have examined clinical features of patients with these tumors. In the absence of available data, it is difficult to identify characteristics of patients with potential PPGLs and normal serum and urine screens. Therefore, an analysis of patients with PPGLs was conducted retrospectively to compare the clinical features of patients with positive and negative catecholamines. This study included 214 patients, including 69 patients with negative catecholamines. Prevalence rates of diabetes (p < 0.001) and hypertension (p < 0.001) were lower and tumor diameter (p < 0.001) was smaller in the negative-catecholamine group compared with the positive-catecholamine group. Multivariable logistic regression analysis showed that extra-adrenal PPGLs were independently positively associated with negative catecholamines (p = 0.004); hypertension (p = 0.001) and tumor diameter (p = 0.016) were independently negatively associated with negative catecholamines. There was no significant difference in tumor recurrence between the two groups (mean follow-up, 20.54 ± 11.83 months) (p = 0.44). The results demonstrated that PPGL patients with negative catecholamines were more likely to have extra-adrenal tumors and less likely to have comorbidities, and these patients should also be closely monitored for tumor recurrence.
The Shape of the Jaw—Zebrafish Col11a1a Regulates Meckel’s Cartilage Morphogenesis and Mineralization
Authors: Reeck Jonathon C. , Oxford Julia Thom
Published: September 2022

The expression of the col11a1a gene is essential for normal skeletal development, affecting both cartilage and bone. Loss of function mutations have been shown to cause abnormalities in the growth plate of long bones, as well as in craniofacial development. However, the specific effects on Meckel’s cartilage have not been well studied. To further understand the effect of col11a1a gene function, we analyzed the developing jaw in zebrafish using gene knockdown by the injection of an antisense morpholino oligonucleotide using transgenic Tg(sp7:EGFP) and Tg(Fli1a:EGFP) EGFP reporter fish, as well as wildtype AB zebrafish. Our results demonstrate that zebrafish col11a1a knockdown impairs the cellular organization of Meckel’s cartilage in the developing jaw and alters the bone formation that occurs adjacent to the Meckel’s cartilage. These results suggest roles for Col11a1a protein in cartilage intermediates of bone development, the subsequent mineralization of the bony collar of long bones, and that which occurs adjacent to Meckel’s cartilage in the developing jaw.
Four Severity Levels for Grading the Tortuosity of a Retinal Fundus Image
Authors: Badawi Sufian Abdul Qader , Takruri Maen , Albadawi Yaman , Khattak Muazzam A. Khan , Nileshwar Ajay Kamath , Mosalam Emad
Published: September 2022

Hypertensive retinopathy severity classification is proportionally related to tortuosity severity grading. No tortuosity severity scale enables a computer-aided system to classify the tortuosity severity of a retinal image. This work aimed to introduce a machine learning model that can identify the severity of a retinal image automatically and hence contribute to developing a hypertensive retinopathy or diabetic retinopathy automated grading system. First, the tortuosity is quantified using fourteen tortuosity measurement formulas for the retinal images of the AV-Classification dataset to create the tortuosity feature set. Secondly, a manual labeling is performed and reviewed by two ophthalmologists to construct a tortuosity severity ground truth grading for each image in the AV classification dataset. Finally, the feature set is used to train and validate the machine learning models (J48 decision tree, ensemble rotation forest, and distributed random forest). The best performance learned model is used as the tortuosity severity classifier to identify the tortuosity severity (normal, mild, moderate, and severe) for any given retinal image. The distributed random forest model has reported the highest accuracy (99.4%) compared to the J48 Decision tree model and the rotation forest model with minimal least root mean square error (0.0000192) and the least mean average error (0.0000182). The proposed tortuosity severity grading matched the ophthalmologist’s judgment. Moreover, detecting the tortuosity severity of the retinal vessels’, optimizing vessel segmentation, the vessel segment extraction, and the created feature set have increased the accuracy of the automatic tortuosity severity detection model.
Sustainable Approaches to Realize Carbon Neutrality in China: A Case Study of Zhejiang Province
Authors: Shu Yuexuan , Chen Jiwei , Huang Yifan , Fu Weiqi
Published: September 2022

With the continuous development of industry, the massive emission of carbon dioxide (CO2) has become a global challenge that cannot be ignored due to its nature as the primary driver of global climate change and environmental crisis. Carbon neutrality is proposed as a global initiative to mitigate climate change. As a developing industrial country, China provides about one-third of global carbon emissions and has set a carbon-neutral goal by 2060. To achieve this goal, continuous efforts across the country are required. In this review, Zhejiang Province, one of the most developed regions in China, is set as a model for analysis. We first summarize the current situation of carbon emission in Zhejiang Province. Then, corresponding sustainable approaches such as ecological and industrial solutions for the reduction of future carbon emissions are introduced for Zhejiang Province. We also provide a direction for the realization of carbon neutrality, focusing on the most promising solutions for Zhejiang Province.
Coupled-Mode Parabolic Equations for the Modeling of Sound Propagation in a Shallow-Water Waveguide with Weak Elastic Bottom
Authors: Kozitskiy Sergey
Published: September 2022

In this work, a mode parabolic equation method with interacting modes accounting for the weak elasticity at the bottom is developed. An important feature of the proposed method is that computations of elastic modes are avoided and that the solution is obtained in the form of expansion over acoustic modes. A numerical technique for solving resulting mode parabolic equations is developed, and the accuracy and efficiency of the resulting solution is validated by a direct comparison against source image solutions in the 3D wedge benchmark problem. Satisfactory agreement of the two solutions is achieved for sufficiently small values of shear wave speed that are typical for soft sediments of the sea bottom. The developed approach may be used for solving 3D problems of sound propagation with the elastic properties of bottom sediments taken into account.
Nationwide Surveillance of Antifungal Resistance of Candida Bloodstream Isolates in South Korean Hospitals: Two Year Report from Kor-GLASS
Authors: Won Eun Jeong , Choi Min Ji , Jeong Seok Hoon , Kim Dokyun , Shin Kyeong Seob , Shin Jeong Hwan , Kim Young Ree , Kim Hyun Soo , Kim Young Ah , Uh Young , Ryoo Namhee , Park Jeong Su , Park Kyoung Un , Byun Seung A. , Lee Ga Yeong , Kim Soo Hyun , Shin Jong Hee
Published: September 2022

We incorporated nationwide Candida antifungal surveillance into the Korea Global Antimicrobial Resistance Surveillance System (Kor-GLASS) for bacterial pathogens. We prospectively collected and analyzed complete non-duplicate blood isolates and information from nine sentinel hospitals during 2020–2021, based on GLASS early implementation protocol for the inclusion of Candida species. Candida species ranked fourth among 10,758 target blood pathogens and second among 4050 hospital-origin blood pathogens. Among 766 Candida blood isolates, 87.6% were of hospital origin, and 41.3% occurred in intensive care unit patients. Adults > 60 years of age accounted for 75.7% of cases. Based on species-specific clinical breakpoints, non-susceptibility to fluconazole, voriconazole, caspofungin, micafungin, and anidulafungin was found in 21.1% (154/729), 4.0% (24/596), 0.1% (1/741), 0.0% (0/741), and 0.1% (1/741) of the isolates, respectively. Fluconazole resistance was determined in 0% (0/348), 2.2% (3/135, 1 Erg11 mutant), 5.3% (7/133, 6 Pdr1 mutants), and 5.6% (6/108, 4 Erg11 and 1 Cdr1 mutants) of C. albicans, C. tropicalis, C. glabrata, and C. parapsilosis isolates, respectively. An echinocandin-resistant C. glabrata isolate harbored an F659Y mutation in Fks2p. The inclusion of Candida species in the Kor-GLASS system generated well-curated surveillance data and may encourage global Candida surveillance efforts using a harmonized GLASS system.
The Small Ras Superfamily GTPase Rho4 of the Maize Anthracnose Fungus Colletotrichum graminicola Is Required for β-1,3-glucan Synthesis, Cell Wall Integrity, and Full Virulence
Authors: Oliveira-Garcia Ely , Aliyeva-Schnorr Lala , De Oliveira Silva Alan , El Din Ghanem Seif , Thor Kathrin , Peiter Edgar , Deising Holger B.
Published: September 2022

Small Ras superfamily GTPases are highly conserved regulatory factors of fungal cell wall biosynthesis and morphogenesis. Previous experiments have shown that the Rho4-like protein of the maize anthracnose fungus Colletotrichum graminicola, formerly erroneously annotated as a Rho1 protein, physically interacts with the β-1,3-glucan synthase Gls1 (Lange et al., 2014; Curr. Genet. 60:343–350). Here, we show that Rho4 is required for β-1,3-glucan synthesis. Accordingly, Δrho4 strains formed distorted vegetative hyphae with swellings, and exhibited strongly reduced rates of hyphal growth and defects in asexual sporulation. Moreover, on host cuticles, conidia of Δrho4 strains formed long hyphae with hyphopodia, rather than short germ tubes with appressoria. Hyphopodia of Δrho4 strains exhibited penetration defects and often germinated laterally, indicative of cell wall weaknesses. In planta differentiated infection hyphae of Δrho4 strains were fringy, and anthracnose disease symptoms caused by these strains on intact and wounded maize leaf segments were significantly weaker than those caused by the WT strain. A retarded disease symptom development was confirmed by qPCR analyses. Collectively, we identified the Ras GTPase Rho4 as a new virulence factor of C. graminicola.
How Can We Promote Sustainable Regional Development and Biodiversity Conservation in Regions with Demographic Decline? The Case of UNESCO Biosphere Reserve Elbe River Landscape Brandenburg, Germany
Authors: Aschenbrand Erik
Published: September 2022

This paper analyzes the relationship between out-migration from rural areas, sustainable regional development and the conservation of biodiversity. Urbanization is a key challenge for sustainable development. Will the move to cities reduce land use pressures on rural areas, and thus provide opportunities for biodiversity conservation? This paper reviews the literature on the relationship between rural out-migration and biodiversity. Generalizing statements or even predictions are rarely possible, as regional contexts differ greatly and a multitude of factors are at work. It is apparent, however, that traditional land use practices, in particular, are in decline as a result of out-migration. In some cases, this can lead to intensification, in others to abandonment, while some studies do not show any link at all. The paper then considers the case study of a peripheral biosphere reserve in Germany that is characterized by strong out-migration. Here, the urbanization tendency is evident on a smaller scale; the regional urban center consolidates, and the small communities face great challenges. At the same time, new innovative actors are emerging. It is essential for new and established actors to collaborate and jointly develop new narratives for “shrinking” regions.
Examining Social Equity in the Co-Management of Terrestrial Protected Areas: Perceived Fairness of Local Communities in Giant Panda National Park, China
Authors: Chen Qiujin , Zhang Yuqi , Zhang Yin , Kong Mingliang
Published: September 2022

Social equity is imperative both morally and instrumentally in the governance of protected areas, as neglecting this consideration can result in feelings of injustice and thus jeopardize conservation objectives. Despite the progressive attention paid to conservation equity, few have linked it with co-management arrangements, especially in the context of terrestrial protected areas. This study assesses the fairness perceptions in China’s Giant Panda National Park from recognitional, procedural, and distributional dimensions, to further disclose their correlations with individuals’ characteristics and participation in co-management activities. The regression analysis shows that all co-management types (instruction, consultation, agreement, and cooperation) are significantly linked with certain directions of perceived social equity. One novel finding here is that alternative types of co-management activities are influencing social equity in different ways. In addition, our research discloses the effects of education across all equity categories, and location is merely significantly related to recognitional equity. These findings suggest more inclusive and empowered co-management endeavors to strive for more equitably managed protected areas. Crucial steps to advance this include extending participative channels, co-producing better compensation plans, strengthening locals’ conservation capabilities, etc. Herein, this study appeals to a greater focus on social equity issues in co-management regimes, and tailored actions should be taken to tackle specific local problems.
How Does the Spatial Misallocation of Land Resources Affect Urban Industrial Transformation and Upgrading? Evidence from China
Authors: Peng Shangui , Wang Jian , Sun Hao , Guo Zhengning
Published: September 2022

Industrial transformation and upgrading is a key variable for developing countries to become developed countries. In China’s institutional environment, the central government’s decisions regarding the spatial allocation of land resources cause a differentiation in the evolution of industrial structures and formats among regions, generating significant impacts on urban industrial transformation and upgrading (UITU), with important policy implications. Using panel data from 276 prefecture-level cities in China from 2007 to 2019, this study constructs a spatial panel econometric model and a mediating effect model to reveal how land spatial misallocation (LSM) affects UITU. The results show that, LSM is not conducive to UITU, and this adverse effect is greater in cities with a relative land supply shortage than in cities with a relative land supply surplus. Further research finds that the LSM caused by the relative land supply shortage affects the UITU mainly through intermediate mechanisms that crowd out the investments and financing for real industries and inhibit residents’ demand and innovation, and the LSM caused by the relative land supply surplus affects the UITU mainly through intermediate mechanisms that enhance the survival of low-end industries and disrupt the institutional environment. From these findings, this study not only puts forward specific policy recommendations for optimizing the allocation of land resources in China to promote UITU, but also discusses the implications for related research and practice in other countries.
Innovation-Driven Development and Urban Land Low-Carbon Use Efficiency: A Policy Assessment from China
Authors: Xu Ning , Zhao Desen , Zhang Wenjie , Zhang He , Chen Wanxu , Ji Min , Liu Ming
Published: September 2022

Improving the low-carbon utilization efficiency of urban land is crucial to the low-carbon transformation and sustainable development of China and the world economy. Innovation-driven development, especially the construction of National Independent Innovation Demonstration Zones (NIIDZs), is an important measure to realize the low-carbon transformation of urban land use and sustainable economic development in China. However, previous studies have neglected to study the impact of the construction of NIIDZs on the low-carbon utilization efficiency of urban land. Based on a theoretical analysis and using the panel data of 283 cities in China from 2006 to 2019, we took NIIDZ construction in China as a quasi-natural experiment and adopted the progressive difference-in-differences method (DID) to evaluate the impact and action mechanism of NIIDZ construction on urban land low-carbon utilization efficiency. We found that NIIDZ construction can significantly promote the improvement of the low-carbon utilization efficiency of urban land, and a series of robustness analysis results support this research conclusion. With the passage of time, this kind of promotion effect shows a trend of increasing fluctuation. NIIDZ construction mainly improves the low-carbon utilization efficiency of urban land by promoting green technology innovation and generating economies of scale. In addition, compared with eastern cities, small-scale cities and resource-based cities, the promotion effect of NIIDZ construction in central and western cities, large cities, and non-resource-based cities is more obvious. This study provides a theoretical basis and practical reference for the low-carbon utilization of urban land from the perspective of innovation in China.
Effect of the Bionic Circular Groove Non-Smooth Structure on the Anti-Wear Performance of the Two-Vane Pump
Authors: Gu Yunqing , Yan Muhan , Yu Jiayun , Xia Ke , Ma Longbiao , Mou Jiegang , Wu Denghao , Tang Jianxing
Published: September 2022

The characteristics of the material transported by the two-vane pump can cause the impeller to wear out, leading to a deterioration in hydraulic efficiency. Appropriately, the research goal of this paper is to consolidate the anti-wear performance of the two-vane pump conveying a solid-liquid two-phase flow. Based on the bionic principle and the anti-wear structure of blood clams, the circular non-smooth structure adapted from blood clams is arranged in the wear-prone area. Through numerical simulation, we compare the main indexes of the pump: the head, the pressure distribution, the vortex pressures, and the average wear rate, to reveal the wear resistance mechanism of circular non-smooth structures. The results illustrate that the use of a circular non-smooth structure does not modify the external characteristics of the pump; the pressure distribution inside the impeller is similarly consistent, and the vortex pressures are all approximately the same. The average wear rate is higher when the diameter of the circular non-smooth structure is either 0.25 mm or 0.30 mm, and the simulation results are poor. At a diameter of 0.20 mm, the average wear rate of circular non-smooth blades is at its lowest point. The circular non-smooth surface structure causes impurities to be “caught” by the vortex zone and not freely struck against the wall, resulting in the particles migrating away from the blade.
Manufacturing of Ti-Nb-Cr-V-Ni-Al Refractory High-Entropy Alloys Using Direct Energy Deposition
Authors: Jeong Ho-In , Lee Choon-Man , Kim Dong-Hyeon
Published: September 2022

High-entropy alloys (HEAs) are composed of 5–35 at% of five or more elements, have high configurational entropy, do not form intermetallic compounds, and have a single-phase face-centered cubic structure or body-centered cubic structure. In particular, refractory HEAs (RHEAs), based on refractory materials with excellent mechanical properties at high temperatures, have high strength and hardness at room temperature and excellent mechanical properties at low and high temperatures. In this study, the Ti-Nb-Cr-V-Ni-Al RHEAs were deposited using direct energy deposition (DED). In the microstructure of Ti-Nb-Cr-V-Ni-Al, the sigma, BCC A2, and Ti2Ni phases appeared to be different from the BCC A2, BCC B2, and Laves phases predicted in the phase diagram. This microstructure was similar to that of the casted Ti-Nb-Cr-V-Ni-Al and had a constructed fine grain size. It was found that the growth of these microstructures was due to the DED process, which has a fast solidification rate. The fine grain size caused high hardness, and the microhardness of the Ti-Nb-Cr-V-Ni-Al was measured to be about 900 HV. In addition, in order to analyze the thermal properties of Ti-Nb-Cr-V-Ni-Al composed of the refractory material, the heat-affected zone (HAZ) was analyzed through a preheating test. The HAZ was decreased, owing to the high thermal diffusivity of Ti-Nb-Cr-V-Ni-Al.
Porous Biochar Supported Transition Metal Phosphide Catalysts for Hydrocracking of Palm Oil to Bio-Jet Fuel
Authors: Kaewtrakulchai Napat , Smuthkochorn Araya , Manatura Kanit , Panomsuwan Gasidit , Fuji Masayoshi , Eiad-Ua Apiluck
Published: September 2022

The upgrading of plant-based oils to liquid transportation fuels through the hydrotreating process has become the most attractive and promising technical pathway for producing biofuels. This work produced bio-jet fuel (C9–C14 hydrocarbons) from palm olein oil through hydrocracking over varied metal phosphide supported on porous biochar catalysts. Relative metal phosphide catalysts were investigated for the highest performance for bio-jet fuel production. The palm oil’s fiber-derived porous biochar (PFC) revealed its high potential as a catalyst supporter. A series of PFC-supported cobalt, nickel, iron, and molybdenum metal phosphides (Co-P/PFC, Ni-P/PFC, Fe-P/PFC, and Mo-P/PFC) catalysts with a metal-loading content of 10 wt.% were synthesized by wet-impregnation and a reduction process. The performance of the prepared catalysts was tested for palm oil hydrocracking in a trickle-bed continuous flow reactor under fixed conditions; a reaction temperature of 420 °C, LHSV of 1 h−1, and H2 pressure of 50 bar was found. The Fe-P/PFC catalyst represented the highest hydrocracking performance based on 100% conversion with 94.6% bio-jet selectivity due to its higher active phase dispersion along with high acidity, which is higher than other synthesized catalysts. Moreover, the Fe-P/PFC catalyst was found to be the most selective to C9 (35.4%) and C10 (37.6%) hydrocarbons.
Some Issues with Statistical Crystal Plasticity Models: Description of the Effects Triggered in FCC Crystals by Loading with Strain-Path Changes
Authors: Shveykin Alexey , Romanov Kirill , Trusov Peter
Published: September 2022

The justification of the applicability of constitutive models to exploring technological processes requires a detailed analysis of their performance when they are used to describe loadings including the complex loading mode that is characteristic of these processes. This paper considers the effect of equivalent stress overshooting after the strain-path changes known to occur in metals and alloys. The macrophenomenological and multilevel models, which are based on crystal plasticity, account for this effect by applying anisotropic yield criteria at the macro- and mesolevels, respectively. We introduce a two-level constitutive statistical inelastic deformation model (identified for aluminum) that incorporates the popular simple phenomenological anisotropic hardening law for describing the behavior of FCC polycrystals. The results of the numerical simulation are in satisfactory agreement with existing experimental data. Statistical analysis of the motion of a mesostress in the stress space on the crystallite yield surface is performed. The obtained data are compared with the results found using the isotropic hardening law. The results clarify the simulation details of statistical crystal plasticity models under loading with strain-path changes in materials and demonstrate their suitability for describing the processes under consideration.
Effect of Graphene Oxide Addition on the Anticorrosion Properties of the Phosphate Coatings in Neutral and Acidic Aqueous Media
Authors: Bautin Vasily , Bardin Ilya , Kvaratskheliya Askar , Yashchuk Sergey , Hristoforou Evangelos
Published: September 2022

Graphene oxide (GO) is an advanced additive improving the properties of various types of coatings and intensifying the deposition process. In this work, GO is used as an additive to the traditional phosphating solution of the widely used Russian low-carbon steel 08YU (DC04). The anticorrosion properties of the obtained phosphate coatings were investigated in neutral (0.5 M NaCl) and acidified (0.1 M Na2SO4 + 0.02 M H2SO4) aqueous solutions. Increasing the GO concentration in the phosphating solution to 0.3 g/L was found to improve the anticorrosion properties of the phosphate coatings in neutral NaCl solutions. At the same time, in acidified Na2SO4 solutions, the corrosion rate of 08YU steel with phosphate coatings increased as a function of the GO concentration. It is assumed that a possible reason for various corrosive behavior is the influence of the GO plates distributed in the coating on the rate of the oxygen or hydrogen reduction reactions.
Effect of Fluoride Content of Mouthwashes on Superelastic Properties of NiTi Orthodontic Archwires
Authors: Pastor Francisco , Rodríguez Juan Carlos , Barrera José María , Delgado García-Menocal José Angel , Brizuela Aritza , Puigdollers Andreu , Espinar Eduardo , Gil Javier
Published: September 2022

The influence of sodium fluoride (NaF) concentration in mouthwashes on the properties of superelastic NiTi orthodontic wires has been studied. In this work, 55.8%Ni and 44.2%Ti (in weight) wires were introduced in commercial mouthwashes with different NaF contents (0, 130, 200 and 380 ppm). The release of Ni2+ and Ti4+ ions was by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) at 1, 4, 7 and 14 days. Superelastic orthodontic wires present at oral temperature the austenitic phase which is transformed into a plastic phase (martensite) by cooling. The temperatures at which this occurs are influenced by the chemical composition. The release of ions from the wire will produce variations in the temperatures and stresses of the stress-induced martensitic transformation. Ms, Mf, As, Af were determined by Differential Scanning Calorimeter (DSC). The transformation stresses (austenite to stress induce martensite) were determined with a servo-hydraulic testing machine at 37 °C. The surfaces for the different times and mouthwash were observed by Scanning Electron Microscope (SEM). The release of Ni2+ in mouthwashes with 380 ppm NaF concentrations reaches 230,000 ppb in 14 days and for Ti4+ 175,000 ppb. When NaF concentrations are lower than 200 ppm the release of Ni and Ti ions is around 1500 ppb after 14 days. This variation in compositions leads to variations in Ms from 27 °C to 43.5 °C in the case of higher NaF concentration. The increasing immersion time and NaF concentrations produce a decrease of Ni in the wires, increasing Ms which exceed 37 °C with the loss of superelasticity. In the same way, the stresses (tooth position corrective) decrease from 270 MPa to 0 MPa due to the martensitic phase. The degradation can produce the growth of precipitates rich in Ti (Ti2Ni). These results are of great interest in the orthodontic clinic in order to avoid the loss of the therapeutic properties of superelastic NiTi due to long immersion in fluoride mouthwashes.
The Reaction Behavior of 2CaO·SiO2 with CaO–SiO2–FeO–P2O5 Slag
Authors: Song Yansong , Hu Xiaojun , Chou Kuochih
Published: September 2022

It is important to clarify the reaction behavior of 2CaO·SiO2 (C2S) during hot metal dephosphorization. In this study, C2S was prepared and added to steel slag to investigate the reaction of C2S particles with CaO–SiO2–FeO–P2O5 slag at 1723 K. The diffusion coefficient of phosphorus in C2S was calculated. In addition, the influence of the addition of BaO to C2S was discussed. The results show that the diffusion coefficient of phosphorus in C2S is 9.23 × 10−14 m2·s−1. The Ca in C2S can be replaced by Ba. Small particles in the solid solution were easily generated from the C2S body by the addition of BaO, which is beneficial for improving the phosphorus partition between the C2S solid phase and the liquid phase of the slag.
Influence of Boundary Impedance of 3D Cavity on Targeted Energy Transfer between a Damped Acoustic Mode and a Nonlinear Membrane Absorber
Authors: Shao Jianwang , Luo Qimeng , Zeng Tao , Wu Xian
Published: September 2022

In order to apply the nonlinear energy sink (NES) to reduce the low-frequency noise inside a 3D acoustic cavity with an impedance boundary, a two degrees-of-freedom (DOF) dynamic model of the coupled system of one damped acoustic mode of a regular 3D acoustic cavity and a nonlinear membrane absorber as the NES is established. The damping coefficient of the acoustic mode is obtained based on the finite element analysis method and the relationship of the boundary impedance and the absorption coefficient of the cavity. Based on the set-up of the system, the damping coefficient of the acoustic mode is determined. The frequency responses and the targeted energy transfer (TET) phenomenon of the coupled system are analyzed, and the theoretical and numerical results of the frequency responses of the system are in good agreement with the experimental ones. The effects of the wall impedance of the cavity on the optimal TET are discussed. With the increase in the impedance ratio of the wall, the amplitude of the acoustic displacement plateau decreases, and the frequency bandwidth of the plateau and the two thresholds of the optimal TET interval of the excitation increase. It provides a comprehensive theoretical model and experimental basis for the application of NES in the actual complex structure and provides a reliable design method and control strategy for controlling vehicle interior low-frequency broadband noise.
Analytic and Computational Analysis of GI/Ma,b/c Queueing System
Authors: Chaudhry Mohan , Gai Jing
Published: September 2022

Bulk-service queueing systems have been widely applied in many areas in real life. While single-server queueing systems work in some cases, multi-servers can efficiently handle most complex applications. Bulk-service, multi-server queueing systems (compared to well-developed single-server queueing systems) are more complex and harder to deal with, especially when the inter-arrival time distributions are arbitrary. This paper deals with analytic and computational analyses of queue-length distributions for a complex bulk-service, multi-server queueing system GI/Ma,b/c, wherein inter-arrival times follow an arbitrary distribution, a is the quorum, and b is the capacity of each server; service times follow exponential distributions. The introduction of quorum a further increases the complexity of the model. In view of this, a two-dimensional Markov chain has to be involved. Currently, it appears that this system has not been addressed so far. An elegant analytic closed-form solution and an efficient algorithm to obtain the queue-length distributions at three different epochs, i.e., pre-arrival epoch (p.a.e.), random epoch (r.e.), and post-departure epoch (p.d.e.) are presented, when the servers are in busy and idle states, respectively.
Dynamics Analysis and Optimal Control for a Delayed Rumor-Spreading Model
Authors: Li Chunru , Ma Zujun
Published: September 2022

In this work, we analyze a delayed rumor-propagation model. First, we analyze the existence and boundedness of the solution of the model. Then, we give the conditions for the existence of the rumor-endemic equilibrium. Regrading the delay as a bifurcating parameter, we explore the local asymptotic stability and Hopf bifurcation of the rumor-endemic equilibrium. By a Lyapunov functional technique, we examine the global asymptotically stability of the rumor-free and the rumor-endemic equilibria. We provide two control variables in the rumor-spreading model with time delay, and get the optimal solution via the optimal procedures. Finally, we present some numerical simulations to verify our theoretical predictions. They illustrate that the delay is a crucial issue for system, and it can lead to not just Hopf bifurcation but also chaos.