bluuebunny/crossref_metadata_2025 huggingface dataset:
Avaliação quali-quantitativa da arborização no Centro de Ciências Agroveterinárias da Universidade do Estado de Santa Catarina – CAV/Udesc
Authors: Charline Zangalli  , Emanoéli de Oliveira  , Guilherme Diego Fockink  , Helena Grossl  , Mabilin de Souza Luz  , Natália Saudade de Aguiar  , Renata Amaral Menin  , Maria Raquel Kanieski
Published: September 2021

Este estudo objetivou caracterizar a arborização do campus do Centro de Ciências Agroveterinárias da Universidade do Estado de Santa Catarina (CAV/Udesc), em Lages (SC). Realizou-se inventário quali-quantitativo das árvores e arbustos, em que se avaliaram estágio de desenvolvimento, fenologia, fitossanidade e poda e se calcularam os parâmetros de frequência absoluta e relativa para cada espécie. Foram encontrados 578 indivíduos, de 91 espécies e 37 famílias botânicas. A família Fabaceae foi a mais representativa. Em relação à origem, 63,7% das espécies são nativas do Brasil (73% dos indivíduos). Entre as espécies exóticas, destaca-se Ligustrum lucidum, com elevada frequência relativa. Quanto ao estágio de desenvolvimento, a maioria dos indivíduos está em estágio regular (60%) e jovem (38%), com poucos indivíduos cortados e mortos. A maioria dos indivíduos possui boa quantidade de folhas (81%), ausência de flores (93%) e ausência de frutos (83%). Observouse baixa incidência de cupins, fungos e epífitas, contudo salienta-se a presença expressiva de erva-de-passarinho em algumas espécies. A maioria dos indivíduos avaliados não sofreu podas (60%), estando a maior parte deles em condição boa ou satisfatória. Concluiu-se que a arborização do campus apresentou considerável riqueza de espécies, com poucos problemas graves, podendo ser caracterizada como heterogênea, em virtude da distribuição uniforme dos indivíduos entre as espécies.
Bacias hidrográficas como unidades de variação geográfica e de conservação de vertebrados
Authors: Mario Arthur Favretto  , Emili Bortolon Dos Santos
Published: September 2021

É fato que os vertebrados sofrem variação em sua distribuição de acordo com vários fatores, tais como uso da terra e altitude. Esses animais podem apresentar diferenças em sua composição no mesmo bioma, dentro de certa unidade geográfica, e.g. no estado de um país. Esta pesquisa analisou a composição de diferentes espécies de vertebrados na bacia hidrográfica do Rio do Peixe, no sul do Brasil. Verificou-se que todos os grupos de fauna, com exceção de peixes e anfíbios, sofreram variação geográfica significante ao longo de três regiões específicas da área de estudo. Tais resultados mostram que as bacias hidrográficas provavelmente funcionam como unidades de variação geográfica de vertebrados neotropicais. Dessa maneira, deve haver políticas de conservação para as diferentes áreas de uma bacia hidrográfica, o que contribui para a manutenção das espécies de vertebrados.
Expansão escolar na periferia de São Paulo: o caso de Ermelino Matarazzo
Authors: Adriana Santiago Rosa Dantas  , Graziela Serroni Perosa
Published: September 2021

Este artigo tem como objetivo examinar a expansão dos estabelecimentos escolares do distrito de Ermelino Matarazzo, localizado na periferia de São Paulo, com base na relação entre dimensão, densidade e heterogeneidade social de uma cultura urbana. Para tanto, analisa-se o crescimento geográfico e populacional e como a influência desses fatores se manifestou na instalação de escolas públicas e privadas, explicitando as diferenças internas do distrito.
Aspectos anatômicos de madeiras históricas do período colonial do nordeste de Santa Catarina: elementos para conservação do patrimônio cultural
Authors: João Carlos Ferreira de Melo Júnior
Published: September 2021

A utilização da madeira é amplamente observada em obras que testemunham o patrimônio cultural brasileiro e é significativa no contexto arquitetônico germânico sulbrasileiro colonial em estruturas de origem germânica da tipologia construtiva enxaimel. Este estudo tem o objetivo de identificar taxonomicamente as espécies vegetais empregadas na edificação de uma casa enxaimel datada de 1860, na qual se caracteriza a influência alemã no período colonial no município de Joinville (SC). Preparações histológicas foram confeccionadas com amostras de madeiras históricas coletadas, seguindo os planos de orientação para microscopia. A caracterização do lenho adotou a terminologia proposta pelo Iawa. Os resultados evidenciam que as estruturas construtivas foram produzidas com diferentes madeiras de ocorrência na mata atlântica. Destacam-se os gêneros Aspidosperma, Cariniana, Centrolobium, Cedrela, Handroanthus, Ocotea, Nectandra e Terminalia. A utilização de diferentes madeiras sugere conhecimento por parte dos construtores sobre aspectos tecnológicos do lenho e sua correta empregabilidade, uma vez que os valores de densidade básica, em sua maioria, as caracterizam como madeiras pesadas e, por conseguinte, de grande durabilidade e resistência mecânica. A apropriação desse conhecimento pode contribuir com ações de conservação do patrimônio histórico, respeitando-se seus significados culturais.
Aquém do capital, além do humano
Authors: Dalvit Greiner de Paula
Published: September 2021

Partindo do princípio de que a cultura reflete os desejos dos grupos de ocupar um território e de construir um futuro comum como condição de sua sobrevivência material e imaterial, este artigo discute a necessidade de rever a posição do Estado, neste caso entendido como a cidade, diante da distribuição de recursos para produzir cultura no país. Considera-se que a cultura, como um direito humano e um bem social inalienável, não deve ficar à mercê do capital nem do mercado como reguladores da produção e da oferta desses bens à sociedade.
Editorial
Authors: Adriane Cristina Kasprowicz
Published: September 2021

xxxxxxxxxxxxxxxx
Oral rehabilitation with removable dental prosthesis in a six-year-old patient with hypohidrotic ectodermal dysplasia
Authors: Mariana Dalledone  , Fernanda Mara de Paiva Bertoli  , Ana Paula Sponchiado  , Estela Maris Losso  , João Armando Brancher  , Juliana Feltrin de Souza
Published: September 2021

Ectodermal dysplasia is an abnormality of the ectoderm and its derivatives, phenotypically expressed in males and genetically inherited from mothers. Objective: To report the efficacy of the prosthetics treatment of severe ectodermal dysplasia in a 6-year-old boy with hypohidrotic ectodermal dysplasia (HED). Case report: The boy had difficulty in speaking and eating and the condition also affected his self-esteem. Prosthetic treatments included the construction of acrylic custom trays, determination of the vertical dimension of occlusion (VDO), construction of upper and lower dentures, and palatal expansion procedure. Conclusion: Significant improvements in the patient’s stomatognathic function and self-esteem were evident.
Critical analysis of methodologies for valuation of esthetic damage and the forensic application in Brazil
Authors: Flávia Vetter  , Rodrigo Torres Pereira  , Lilian Lígia Block  , Wellington Menyrval Zaitter  , Rogério Nogueira de Oliveira  , Mário Marques Fernandes
Published: September 2021

The esthetic damage is any pejorative modification in static or dynamic expression, perceived by any sense, affecting the image of the person. The esthetic damage repair has legal support in Brazilian legislation. Objective: to systematize the different existing methods for valuation of esthetic damages, critically analyze their characteristics, advantages and disadvantages; and evaluate whether these methods would have been validated in any population inside or outside of Brazil. Literature review: The adoption of the use of tables, formulas and coefficients was insufficient to overcome the limitations of each method, such as those supported by the measurement of a single scar or by the teeth. Conclusion: All available subjective methods, except for AIEL method did not have scientific evidence, lacking validation in any country, and requiring proof of methodology.
Padrões estéticos dentais em pessoas com e sem sorriso gengival
Authors: Vanessa Bassotto Pedrozo  , Raquel Pippi Antoniazzi  , Tatiana Pereira-Cenci  , Carlos Eduardo Agostini Balbinot  , Jovito Adiel Skupien
Published: September 2021

: O presente estudo avaliou o comprimento e a proporção dentária em dentes anterossuperiores de pacientes com e sem sorriso gengival. Material e métodos: Selecionaram-se 38 indivíduos para cada um dos grupos: caso (sorriso gengival) e controle. Modelos de gesso foram obtidos mediante moldagem das arcadas, para então serem realizadas as mensurações. Também se submeteram os pacientes a um breve questionário. Resultados: Os dados foram tabulados e analisados por meio de análise de variância sob um nível de significância de 5%. Em ambos os grupos, a maioria foram mulheres (68,4%), brancos (98,7%), com idade variando de 18 a 28 anos. A maior altura encontrada foi para o dente 21 do grupo controle (9,88 mm), e a maior proporção para o dente 11 do grupo caso (87,43%). Analisando a classe dentária, somente a proporção dos incisivos centrais dos casos foram estatisticamente diferentes (p = 0,041), com uma proporção maior. Conclusão: Indivíduos com sorriso gengival possuem proporção dentária maior do que aqueles que não apresentam, entretanto nem todos os dentes podem ter tal diferença.
Tratamento de pigmentações melânicas com instrumentos rotatórios e lâmina de bisturi
Authors: Paula Porto Spada  , Ana Luiza Girardi  , Thayna Souza Silva  , Guilherme Schuldt  , Darlan Rigo Junior  , João Armando Brancher  , Tatiana Deliberador  , Carmen Storrer  , Felipe Rychuv Santos
Published: September 2021

As lesões pigmentadas na cavidade bucal têm diversas características clínicas, que podem variar desde uma pigmentação fisiológica, como as manchas melânicas, até algo mais grave, como o melanoma maligno. Pela grande diversidade de lesões pigmentadas, os tratamentos são variados e individualizados. Objetivo: Remover manchas melânicas por meio de uma técnica cirúrgica que associa instrumentos rotatórios e lâmina de bisturi. Relato de caso: Paciente de 34 anos, melanoderma, procurou atendimento na Universidade Positivo queixando-se das manchas escurecidas visíveis em sua gengiva e do incômodo que elas lhe causavam por se destacarem ao sorrir. Após o exame clínico, diagnosticou-se presença de pigmentações melânicas. O tratamento proposto foi a remoção cirúrgica das manchas com broca e lâmina de bisturi. No pós-cirúrgico imediato a paciente apresentou boa cicatrização e relatou apenas leve ardência nos três primeiros dias. Após 60 dias, a gengiva se apresentava cicatrizada, sem recidiva das manchas. Conclusão: A técnica escolhida mostrou-se efetiva pois houve cicatrização adequada sem recidiva da pigmentação no acompanhamento pós-operatório.
Efeito da vibração sônica na película de cimento para união de pinos de fibra de vidro à dentina radicular – avaliação por MEV
Authors: Thais Mariana Neves Chaves  , Amanda M. Mushashe  , Rodrigo Otavio Jatahy Ferreira do Amara  , Carla Castiglia Gonzaga  , Carlos Eduardo E. Rezende
Published: September 2021

A decimentação de pinos de fibra pré-fabricados é uma complicação clínica relativamente frequente. Diferentes técnicas para cimentação têm sido estudadas e desenvolvidas a fim de reduzir as chances de falha. Nesse contexto, surgiu a técnica que utiliza a vibração sônica para cimentação de pinos de fibra. Objetivo: Avaliar, por meio de microscopia eletrônica de varredura (MEV), o efeito da vibração sônica nas características da película de cimento entre pinos de fibra de vidro e dentina radicular em raízes bovinas. Material e métodos: Raízes de incisivos bovinos foram tratadas endodonticamente e distribuídas aleatoriamente em quatro grupos: SVS (aplicação convencional do sistema adesivo e do cimento), VSA (aplicação sônica do sistema adesivo + aplicação convencional do cimento), VSP (aplicação convencional do sistema adesivo + aplicação sônica do cimento) e VSAP (aplicação sônica do sistema adesivo + aplicação sônica do cimento). Posteriormente, foram obtidas fatias de cada raiz, correspondendo aos terços cervical, médio e apical. As fatias foram submetidas à análise em MEV para avaliação da película de cimento, a fim de verificar a distribuição e o tamanho dos defeitos, considerando três localidades distintas: interface cimento/pino (CP), camada interna do cimento (LC) e interface cimento/dentina (CD). Resultado: A análise dos resultados permitiu verificar que a incidência de falhas foi menor na região apical e sofria aumento gradual de apical para cervical em todos os grupos estudados. Independentemente da técnica utilizada houve maior número absoluto de falhas na interface cimento/dentina. Conclusão: A técnica de aplicação do adesivo e do cimento pode exercer influência nas características da película de cimento entre o pino de fibra de vidro e as paredes de dentina do conduto radicular.
Behavior of parents and educators following traumatic injury to young permanent teeth of children in Joinville, Santa Catarina
Authors: Jennyffer Samira de Lima  , Jaini Dalprá  , Susimara Braga de Almeida
Published: September 2021

Traumatic dental injuries are a major public health problem, especially in the age range of 7 to 15 years, when young permanent teeth are established. Objective: To evaluate the behavior of parents of children who attend public or private school and their educators, in cases of traumatic injury to young permanent teeth and to evaluate whether they sought emergency guidance, in the city of Joinville, Santa Catarina, Brazil. Evaluation was carried out via a questionnaire for asking the parents and teachers about their knowledge of dental trauma. Material and methods: A total of 248 parents and 22 teachers participated in the study. Out of all the participants that completed the questionnaire with questions on previous trauma experience, avulsion behavior, avulsed tooth storage medium, and time elapsed from dental trauma until care, 49.6% of had higher education. The data were tabulated on a Microsoft Office Excel 365 worksheet, and the chi-square statistical test was applied. Results: The research showed that 91.8% of parents and 8.2% of educators from both public and private schools had minimal knowledge regarding dental trauma. Many of the participants (73.2%) were unaware of what dental reimplantation was and lacked knowledge regarding storage choices for a dental element. Instead, 68% preferred to take the child to a dental surgeon to receive emergency care. Conclusion: The knowledge parents and educators of public and private schools have about dental trauma is limited. Education on this subject needs to be promoted for enabling parents and educators to make informed decisions to ensure the best prognosis after traumatic dental injury.
Comparison between electronic and radiographic method for the determination of root canal length in primary teeth
Authors: Sérgio Luiz Pinheiro  , Iris Nogueira Bincelli  , Talita Faria  , Carlos Eduardo da Silveira Bueno  , Rodrigo Sanches Cunha
Published: September 2021

There are few researches in literature that mention the use of the apex locator in deciduous teeth and working length is obtained through radiographies. Objective: The purpose of this research was to compare the radiographic and the electronic method to obtain the working length in deciduous molars. Material andmethods: Twelve molar teeth were used. The specimens in the visual method had their root length measured through the passive insertion of a 10 K-file with a silicone stop within root canal until its tip was seen at the apical foramen. The working length was measured through radiographs or using the apex locator Root ZX II. The mean between the examiners was submitted to the variance analysis (ANOVA). Results: Statistically significant differences were found between the visual method and the radiographic method (p < 0.001). There was no significant difference between the working length measurements in visual method and those obtained with the apex locator (p = 0.1319). Conclusion: The apex locator is indicated as a clinical implementation for endodontic treatment in primary teeth.
Antifungal activity of plant-based tinctures on Candida
Authors: Andreia Medeiros Rodrigues Cardoso  , Yuri Wanderley Cavalcanti  , Leopoldina de Fátima Dantas de Almeida  , Ana Luíza Alves de Lima Pérez  , Wilton Wilney Nascimento Padilha
Published: September 2021

To evaluate through determination of minimum inhibitory concentration (MIC) the antifungal activity of Salvia officinalis (sage), Anacardium occidentale (cashew) and Malva sylvestris (mallow) tinctures on Candida albicans (ATCC 40227), C. tropicalis (ATCC 13803) and C. krusei (ATCC 40147). Material and methods: In 96-well microplates, 100 µl of Sabouraud-Dextrose broth doubly concentrated, 100 µl of the tested tinctures and 10 µl of fungal inoculums (1.5 x 106organisms/ml) were inserted. The products were diluted from initial concentration of 100 mg/ml until 0.78 mg/ml. MIC corresponded to the lowest dilution at which there was no visible fungal growth. Nystatin (100,000 UI/ml) was used as control. Statistical analysis was performed by Kruskal-Wallis and Dunn tests (p < 0.05). Results: S. officinalis tincture did not inhibit the growth of C. albicans and C. tropicalis; MIC was 100 mg/ml for C. krusei. For A. occidentale, MIC was 100 mg/ml for C. albicans and C. krusei, and for C. tropicalis, there was no fungal inhibition. M. sylvestris tincture presented MIC at 25 mg/ml for C. krusei and 100 mg/ml for C. albicans and C. tropicalis. The best antifungal activity was showed by M. sylvestris tincture (p < 0.05). Conclusion: M. sylvestris tincture exhibited antifungal activity against all the tested strains at lower concentrations. S. officinalis tincture inhibited the action of C. krusei and A. occidentale tincture showed activity against C. albicans and C. tropicalis.
Gold Nanoparticles in Triple-Negative Breast Cancer Therapeutics
Authors: Akter Zakia , Khan Fabiha Zaheen , Khan Md. Asaduzzaman
Published: September 2021

Background:

Triple-negative breast cancer (TNBC) is the most aggressive
type of breast cancer with enhanced metastasis and poor survival. Though chemotherapy,
radiotherapy, photothermal therapy (PTT), photodynamic therapy (PDT), and gene delivery
are used to treat TNBC, various side effects limit these therapeutics against TNBC. In
this review article, we have focused on the mechanism of action of gold nanoparticles
(AuNPs) to enhance the efficacy of therapeutics with targeted delivery on TNBC cells.

Methods:

Research data were accumulated from PubMed, Scopus, Web of Science, and
Google Scholar using searching criteria “gold nanoparticles and triple-negative breast
cancer” and “gold nanoparticles and cancer”. Though we reviewed many old papers, the
most cited papers were from the last ten years.

Results:

Various studies indicate that AuNPs can enhance bioavailability, site-specific
drug delivery, and efficacy of chemotherapy, radiotherapy, PTT, and PDT as well as
modulate gene expression. The role of AuNPs in the modulation of TNBC therapeutics
through the inhibition of cell proliferation, progression, and metastasis has been proved in
vitro and in vivo studies. As these mechanistic actions of AuNPs are most desirable to develop
drugs with enhanced therapeutic efficacy against TNBC, it might be a promising
approach to apply AuNPs for TNBC therapeutics.

Conclusion:

This article reviewed the mechanism of action of AuNPs and their application
in the enhancement of therapeutics against TNBC. Much more attention is required
for studying the role of AuNPs in developing them either as a single or synergistic anticancer
agent against TNBC.
Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement
Authors: Alt Jesse , Gori Sadakatali S. , Lemberg Kathryn M. , Pal Arindom , Veeravalli Vijayabhaskar , Wu Ying , Aguilar Joanna M.H. , Dash Ranjeet P. , Tenora Lukáš , Majer Pavel , Sun Qi , Slusher Barbara S. , Rais Rana
Published: September 2021

Background:

Metabolomic analyses from our group and others have shown that tumors treated with glutamine
antagonists (GA) exhibit robust accumulation of formylglycinamide ribonucleotide (FGAR), an intermediate
in the de novo purine synthesis pathway. The increase in FGAR is attributed to the inhibition of the enzyme FGAR
amidotransferase (FGAR-AT) that catalyzes the ATP-dependent amidation of FGAR to formylglycinamidine ribonucleotide
(FGAM). While perturbation of this pathway resulting from GA therapy has long been recognized, no study
has reported systematic quantitation and analyses of FGAR in plasma and tumors.

Objective:

Herein, we aimed to evaluate the efficacy of our recently discovered tumor-targeted GA prodrug, GA-607
(isopropyl 2-(6-acetamido-2-(adamantane-1-carboxamido)hexanamido)-6-diazo-5-oxohexanoate), and demonstrate
its target engagement by quantification of FGAR in plasma and tumors.

Methods:

Efficacy and pharmacokinetics of GA-607 were evaluated in a murine EL4 lymphoma model followed by
global tumor metabolomic analysis. Liquid chromatography-mass spectrometry (LC-MS) based methods employing
the ion-pair chromatography approach were developed and utilized for quantitative FGAR analyses in plasma and
tumors.

Results:

GA-607 showed preferential tumor distribution and robust single-agent efficacy in a murine EL4 lymphoma
model. While several metabolic pathways were perturbed by GA-607 treatment, FGAR showed the highest increase
qualitatively. Using our newly developed sensitive and selective LC-MS method, we showed a robust >80- and >10-
fold increase in tumor and plasma FGAR levels, respectively, with GA-607 treatment.

Conclusion:

These studies describe the importance of FGAR quantification following GA therapy in cancer and
underscore its importance as a valuable pharmacodynamic marker in the preclinical and clinical development of GA
therapies.
Health Benefits of Avicularin in the Medicine Against Cancerous Disorders
and other Complications: Biological Importance, Therapeutic Benefit
and Analytical Aspects
Authors: Patel Dinesh Kumar , Patel Kanika
Published: September 2021

Background:

Herbal drugs and their derived phytochemicals have been used in
medicine for the preparation of different types of pharmaceutical products. Pure phytochemicals including
flavonoids, alkaloids and terpenoids have been used in medicine for the treatment of different
types of human disorders including cancerous disorders. Flavonoids have been well known in
medicine for their anti-viral, anti-bacterial, anti-inflammatory, anti-diabetic, anti-cancer, anti-aging
and cardioprotective potential. Avicularin, also called quercetin-3-α-l-arabino furanoside, is a pure
flavonoid, a class of phytochemicals, found to be present in Lindera erythrocarpa and Lespedeza
cuneata. Avicularin has been well known in medicine for its anti-cancer properties.

Methods:

In the present work, scientific data of avicularin have been collected from different
databases such as Google, PubMed, Science Direct, Google Scholar and Scopus and summarized
with reference to medicinal importance, pharmacological activities and analytical aspects of avicularin.
The present review summarized the health beneficial properties of avicularin in medicine
through data analysis of various scientific research works. Further analytical progress in medicine
for the qualitative and quantitative analysis of avicularin in medicine has been also discussed in the
present work.

Results:

Scientific data analysis of different literature work revealed the biological importance of
flavonoid class of phytochemical ‘avicularin’ in medicine. Scientific data analysis revealed that avicularin
was found to be present in the Lindera erythrocarpa, Lespedeza cuneata, Rhododendron
schlipenbachii and Psidium guajava. Avicularin has been well known in medicine for its anti-inflammatory,
anti-allergic, anti-oxidant, anti-tumor and hepatoprotective activities. Avicularin protects
cardiomyocytes and hepatocytes against oxidative stress-induced apoptosis and induces cytotoxicity
in cancer lines and tumor tissues. Avicularin has positive influence on human hepatocellular
carcinoma and inhibits intracellular lipid accumulation. The role of avicularin in rheumatoid
arthritis has been also established with its underlying molecular mechanisms in the scientific work.
Recent interest in avicularin has focused on pharmacological investigations for its anti-cancer activity
in the medicine.

Conclusion:

The present work signified the biological importance of avicularin in medicine
through its medicinal uses, pharmacological activities and analytical aspects in the biological system.
Structural Perspectives and Advancement of SGLT2 Inhibitors for the Treatment of Type 2 Diabetes
Authors: Sharma Shivani , Mittal Amit , Kumar Shubham , Mittal Anu
Published: September 2021

Diabetes mellitus is an ailment that affects a large number of individuals worldwide and its pervasiveness has been predicted to increase later on. Every year, billions of dollars are spent globally on diabetes-related health care practices. Contemporary hyperglycemic therapies to rationalize Type 2 Diabetes Mellitus (T2DM) mostly involve pathways that are insulin-dependent and lack effectiveness as the pancreas’ β-cell function declines more significantly. Homeostasis via kidneys emerges as a new and future strategy to minimize T2DM complications. This article covers the reabsorption of glucose mechanism in the kidneys, the functional mechanism of various Sodium- Glucose Cotransporter 2 (SGLT2) inhibitors, their structure and driving profile, and a few SGLT2 inhibitors now accessible in the market as well as those in different periods of advancement. The advantages of SGLT2 inhibitors are dose-dependent glycemic regulation changes with a significant reduction both in the concentration of HbA1c and body weight clinically and statistically. A considerable number of SGLT2 inhibitors have been approved by the FDA, while a few others, still in preliminaries, have shown interesting effects.
Sacubitril/Valsartan: A New Dawn has Begun! A Revisited Review
Authors: Abdelnabi Mahmoud , Saleh Yehia , Almaghraby Abdallah , Girgis Hany , Gerges Fady
Published: September 2021

:

Heart Failure (HF) is among the major causes of global morbidity as well as mortality.
Increased prevalence, frequent and prolonged hospitalization, rehospitalization, long-term consumption
of healthcare resources, absenteeism, and death upsurge the economic burden linked to
HF. For decades, Angiotensin-Converting Enzyme Inhibitors (ACEIs), Angiotensin II Receptor
Blockers (ARBs), Beta-Blockers (BBs), and mineralocorticoid receptor antagonists (MRA), have
remained the mainstay of the standard of care for HF management. Despite their proven efficacy
and cost-effectiveness, HF remains a global pandemic and is still increasing in prevalence. Sacubitril/
Valsartan (SAC/VAL) is an Angiotensin Receptor/Neprilysin Inhibitor (ARNI) that proved out
to be a game-changer drug in HF treatment. Recent data indicated that SAC/VAL is more efficient
and can improve the overall quality of life of HF patients with reduced ejection fraction (HFrEF)
with fewer side effects. It is now incorporated in the guidelines as an alternative to ACEIs or ARBs
to lower morbidity in addition to mortality in HFrEF patients. This review article will discuss the
current guidelines-approved indications and highlight the potential emerging indications, in addition
to the currently ongoing clinical trials that will expand the use of SAC/VAL.
Novel Non-pharmaceutical Advancements in Heart Failure Management:
The Emerging Role of Technology
Authors: Nolan Mark T. , Tan Neville , Neil Christopher J.
Published: September 2021

Purpose of Review:

To summarise and discuss the implications of recent technological
advances in heart failure care.

Recent Findings:

Heart failure remains a significant source of morbidity and mortality in the US
population despite multiple classes of approved pharmacological treatments. Novel cardiac devices
and technologies may offer an opportunity to improve outcomes. Baroreflex Activation Therapy
and Cardiac Contractility Remodelling may improve myocardial contractility by altering neurohormonal
stimulation of the heart. Implantable Pulmonary Artery Monitors and Biatrial Shunts may
prevent heart failure admissions by altering the trajectory of progressive congestion. Phrenic Nerve
Stimulation offers potentially effective treatment for comorbid conditions. Smartphone applications
offer an intriguing strategy for improving medication adherence.

Novel heart failure technologies offer promise for reducing this public health burden.
Randomized controlled studies are indicated for assessing the future role of these novel therapies.
Prevalence Estimates, Severity, and Risk Factors of Depressive Symptoms among Coronary Artery Disease Patients after Ten Days of Percutaneous Coronary Intervention
Authors: Rawashdeh Sukaina I. , Ibdah Rasheed , Kheirallah Khalid A. , Al-kasasbeh Abdullah , Raffee Liqaa A. , Alrabadi Nasr , Albustami Iyad S. , Haddad Rabia , Ibdah Raed M. , Al-Mistarehi Abdel-Hameed
Published: September 2021

Background:

Depression and cardiovascular disorders are significant determinants of health that affect the quality of life and life expectations. Despite the high importance of depression screening among Coronary Artery Disease (CAD) patients, the time being to assess and treat it remains controversial.

Objectives:

This study aims to assess the prevalence estimates and severity of depressive symptoms and determine the risk factors associated with developing such symptoms among CAD patients after ten days of Percutaneous Coronary Intervention (PCI).

Methods:

All patients who underwent elective PCI between October 5, 2019, and Mid-March 2020 and diagnosed with CAD were included in this cross-sectional study. CAD was defined as intra-luminal stenosis of ≥ 50% in one or more of the coronary arteries. Depressive symptoms were screened after ten days of the PCI utilizing the patient health questionnaire-9 (PHQ-9) tool. A linear regression model was used to assess the adjusted effects of independent variables on PHQ-9 scores. Electronic medical records, clinical charts, and PCI and echocardiogram reports were reviewed.

Results:

Out of 385 CAD patients, a total of 335 were included in this study, with a response rate of 87%. The participants' mean (±SD) age was 57.5±10.7 years, 75.2% were males, 43% were current smokers, and 73.7% had below bachelor's education. The prevalence estimates of patients with moderate to severe depressive symptoms (PHQ-9 ≥10) was 34%, mild depression 45.1%, and normal 20.9%. Female gender, low educational level and diabetes mellitus were found to be the significant independent predictors of depression among our cohort with (t(333) = 3.68, p<0.001); (t(333) = 5.13, p<0.001); and (t(333) = 2.79, p=0.042), respectively.

Conclusion:

This study suggests a high prevalence of depressive symptoms among CAD patients after ten days of PCI. Approximately one out of three patients with CAD have significant symptoms of depression, which is an alarming finding for clinicians. Moreover, this study demonstrates a lack of sufficient depression recognition and management in similar study settings. Integration of mental health assessment and treatment among patients with CAD as soon as after PCI is recommended for optimal and effective treatment and to obtain the best outcomes.
Phytochemical Contents, Biological Activities and Therapeutic Applications
of Hedera Helix (Ivy Leaf) Extracts: A Review
Authors: Shokry Aya , El-Shiekh Riham , Kamel Gehan , Ramadan Amer
Published: September 2021

Background:

Herbs have long been used as natural therapeutics, and recent controlled
clinical studies have confirmed some of the presumed benefits. Hedera helix(ivy leaves) is a valuable
common form related to the family Araliaceae. Many herbal preparations include extracts
from their leaves as the principle active ingredient.

Objective:

The objective of this article is to summarize the pharmacological activities and phytochemical
screening of H. helix.

Methods:

To prepare this article, the data was collected from different sources, including books, thesis,
research and etc.

Results:

The all-published studies depend on isolation, identification, and characterization of different
active constituents of H. helix leaves, followed by the determination of biological activities in
vivo and in vitro. Chemical screening has shown that H. helix leaves are a rich source of phytochemicals
demonstrating therapeutic activities, such as sterols, tannins, terpenoids, glycosides,
phenols, emetine alkaloids, flavonoids, saponins, volatile and fixed oils, vitamins, carbohydrates,
reducing sugars, and minerals. Further, studies of disease models and clinical trials have demonstrated
anti-inflammatory, analgesic, cough suppressant, expectorant, anticancer, antimicrobial, anticoagulant,
and smooth muscle relaxant activities.

Conclusion:

This review summarizes the bioactive constituents of H. helix leaves and their underlying
pharmacological mechanisms, clinical efficacies, and safety profiles. We also suggest potential
therapeutic uses for COVID-19.
Antiviral Properties of Food Plants could help to Reduce Contagion and
Severity in SARS-CoV-2 Infection
Authors: Cardoso Betina
Published: September 2021

Introduction:

It is important to find tools to help patients and prevent viral diffusion of
pneumonia caused by the 2019 novel coronavirus (2019-nCoV or SARS-CoV-2). Recent articles
have reported site-specific SARS-CoV-2 infection on a patient's body, specifically a very active replication
in the throat and upper respiratory tract, even at the mild stage of the disease, which
shows its efficient viral transmission in sputum.

Material and Methods:

An alternative that may be feasible is to resort to scientific studies that demonstrate
the antiviral potential of medicinal plants species through in-vitro and in-vivo experiments
to alleviate symptoms and prevent the spread of contagion. A literature search on Scopus
and PubMed on herbs and foods with antiviral properties was performed.

Results:

This resulted in hundreds of publications showing a diversity of plants with antiviral effects
against different virus infections. This article focuses on plants that are of common use,
which could act against COVID-19.

Conclusions:

Herbs and foods with demonstrated antiviral potential have been identified, limiting
SARS-CoV-2 spread by interfering with ACE2 protein on infection sites. The analysis of transdisciplinary
knowledge allows us to connect previous research on the action of common plants and
foods on viruses to limit the replication of SARS-CoV-2 in the throat and upper respiratory tract.
Research Progress on Oil Sludge Treatment in Oilfield: A Mini-Review
Authors: Deng Jinjun , Zhang Huili , Yu Bo , Liu Hongsheng
Published: September 2021

:

A large amount of sludge produced in the processing of crude oil has brought
great harm. In this paper, common flocculants are summarized. According to the treatment
process of crude oil, flocculants are divided into organic flocculants, inorganic
flocculants, microbial flocculants, composite flocculants, and magnetic flocculants. The
mechanism and limitation of each flocculation on crude oil sludge were analyzed. Finally,
it is pointed out that the flocculation process of sludge is complex, and the development
of new flocculant with high efficiency, safety, and economy is the main trend of
flocculant development in the future.
Studi Perencanaan Bangunan Pelengkap Pada Boezem Di Kelurahan Blimbing Kota Malang
Authors: Fitriyasari Ammy , Andawayanti Ussy , Cahya Evi Nur
Published: September 2021

The area of Blimbing Village is one of the areas of Malang City where often having flood in rainy season. The flood in the Blimbing Village area is caused by the inadequacy of the existing drainage and also not using water absorption building or Boezem effeciently, therefore need some effort to overcome this problem. One of the solution to tackel this problem is make use boezem more efficiently, in order to reduce flood. In the analysis results of design discharge of the study area was obtained for 3.970 m3/ sec for the two years period and 4,606 m3/ sec for five years period. In order to reduce flood at the study area, an alternative flood control is implemented. The alternative is to increase the storage capacity of the Boezem and planned support buildings specifically planning drainage channels, and planning for inlet and outlet of sluice gates. There are alternative, it can reduce flood by 30%. Based on the results of the analysis, it is obtained that the design budget (RAB) for support buildings planning according to the main unit price for the activities of the city of Malang is IDR 146,620,000.
Studi Perencanaan Embung Kembangan Kecamatan Pule Kabupaten Trenggalek Provinsi Jawa Timur
Authors: Mahardhika Tatag Tata , Sisinggih Dian , Suprijanto Heri
Published: September 2021

Kembangan Village in Pule District is a part of Trenggalek Region which have water resources issues including irigation issue and raw water supply issue. This problem happens because the lack of water resources infrastructures. Based on this two issues to it was so importan to design small dams which is placed on Kembangan Village solve the problem. Based on the data and literature, it was recommended to design the small dam by random soil type with vertical core zone. The body of small dam height planned to be design by 13 m (+552 for the elevation), the width was designed by 6 m, the slope of hillside was 1 : 3 for the upstream and 1 : 2.5 for the downstream. Kembangan smalldam using overflow spillway which is equipped with weir typed ogee, transition channel, sloping apron, and stilling basin. The spillway planned to be design by 8 m width with weir height by 2 m. Kembangan small damn have a potential reservoir capacity for 38219.40 m3 to fullfill the irigation and water supply. It was important to analyzing the stability of small dam for the landslide and seepage factors.
Studi Efisiensi Hasil Perubahan Sistem Jaringan Irigasi Berbasis SIG (Sistem Informasi Geografis) pada Daerah Irigasi Kajar 2D, Kajar 2E, Kajar 2F, dan Kajar 2G Kecamatan Lowokwaru, Kota Malang
Authors: Rafif Hanif , Prayogo Tri Budi
Published: September 2021

Referring to the conditions in Lowokwaru sub-district, there was a reduction in the area of rice fields due to an increase in the conversion of paddy fields to residential areas. This study aims to determine changes in the irrigation network system that affect the water distribution system in the irrigation area. This study was conducted using data from 2012 and 2017 which includes a comparative analysis of rice fields using the arc GIS application. analysis of existing irrigation network conditions for comparison of clean water needs of paddy fields. and analysis of the difference in the efficiency of the use of water needs to show whether or not it is still feasible to irrigate the reduced fields due to land use changes in each of the irrigation areas. The results of the study include a comparative analysis of rice fields_Area is losing 9%, losing 7%, losing 18% and losing 6%. Analysis_of_the difference in efficiency_in the use of_water needs_in each Irrigation Area is an increase_ of 10.5%, an increase of 24.33%, an increase of 40.55% and decrease of 34.8%.
Analisis Debit Limpasan dan Indeks Erosivitas Hujan pada Metode USLE Akibat Variasi Intensitas Hujan dengan Alat Rainfall Simulator
Authors: Respatiningrum Amalia Wara , Limantara Lily Montarcih , Andawayanti Ussy
Published: September 2021

The occurrence of rain causes many things, such as surface runoff and rainfall erosivity. The energy of rainfall can make soil eroded. This study aims to determine the effect of rainfall intensity variations on the resulting runoff discharge, rain erosivity index, and erosion rate using the USLE method on a rainfall simulator. A sampling of soil in Pandesari, Pujon, Malang. This study was conducted with rainfall variations, namely 0.5 liter/minute, 1.0 liter/minute, 1.5 liter/minute, and 2.0 liter/minute with a rainfall simulator slope of 5%. As a result, the rainfall intensity significantly affects the runoff discharge in the rainfall simulator, with a coefficient of determination R2 = 0.981. Rainfall intensity also affects the rainfall erosivity in the rainfall simulator with a coefficient of determination R2 = 0.999. And in the USLE method, the rate of erosion is generated by the rainfall intensity with a coefficient of determination R2 = 0.999.Terjadinya hujan mengakibatkan banyak sekali hal, misalnya aliran permukaan dan juga erosivitas hujan. Energi hujan tersebut bisa membuat suatu lahan tererosi. Dalam penelitian ini bertujuan untuk mengetahui pengaruh variasi intensitas hujan terhadap debit limpasan yang dihasilkan, indeks erosivitas hujan, dan besar laju erosi dengan metode USLE pada alat rainfall simulator. Pengambilan sampel tanah di Desa Pandesari, Kecamatan Pujon, Kabupaten Malang. Studi ini dilakukan dengan variasi hujan yaitu 0,5 liter/menit, 1,0 liter/menit, 1,5 liter/menit, dan 2,0 liter/menit dengan kemiringan alat rainfall simulator sebesar 5%. Hasilnya, intensitas hujan sangat memengaruhi debit limpasan pada alat rainfall simulator, dengan koefisien determinasi R2 = 0,981. Intensitas hujan juga memengaruhi erosivitas hujan pada rainfall simulator dengan koefisien determinasi R2 = 0,999. Dan pada metode USLE, laju erosi yang dihasilkan dipengaruhi juga oleh intensitas hujan dengan koefisien determinasi R2 = 0,999.
Analisa Keruntuhan Bendungan Salomekko Kabupaten Bone Dengan Menggunakan Aplikasi Zhong Xing HY21
Authors: Ayu Mirsa , Juwono Pitojo Tri , Asmaranto Runi
Published: September 2021

Bendungan Salomekko terletak di Dukuh Salomekko Desa Ulu Balang, Kecamatan Salomekko, Kabupaten Bone, Provinsi Sulawesi Selatan yang memiliki fungsi utama untuk menyediakan air bagi kebutuhan irigasi pertanian seluas 1722 Ha. Bendungan Salomekko disamping memiliki manfaat juga menyimpan potensi bahaya, yaitu apabila bendungan runtuh. Oleh karena itu, dibutuhkan analisa keruntuhan bendungan Bendungan Salomekko yang diasumsikan akibat overtopping dan pippingÂ  menggunakan aplikasi Zhong Xing HY21. Bedasarkan hasil simulasi melalui aplikasi Zhong Xing HY21, keruntuhan akibat overtopping merupakan peyebab keruntuhan Bendungan Salomekko yang menimbulkan dampak paling besar dengan debit banjir rancangan PMF sebesar 753,862 mÂ³/det dan luas genangan 15,694 km2 dengan tinggi genangan maksimum 7,759 m. Keruntuhan Bendungan Salomekko mengakibatkan 11 desa terdampak pada bagian hilir bendungan dengan jumlah penduduk terkena resiko 2565 jiwa.
Studi Perencanaan Sumur Injeksi Dalam Upaya Penanggulangan Genangan Di Kawasan Perkotaan (Studi Kasus Di RW. 8 Dan 9 â€“ Kelurahan Blimbing, Kota Malang)
Authors: Syafira Annisa Zuyyinani'ma , Bisri Mohammad , Asmaranto Runi
Published: September 2021

RW.8 and 9 areas, Blimbing Sub-district, Malang city is one of the areas that often occur inundation due to changes in land cover and narrowing of drainage channels. The solution is the manufacture of injection wells to determine the inundation, planning, and effectiveness of injection wells at the research site. To analyze it, modeling rain inundationÂ a return period ofÂ 2 years and 5 years using Storm Water Management Model (SWMM) 5.1 application. Calibration results showed for the Root Mean Square Error (RMSE) value, modeling discharge and measurable discharge for a return period of 2 years is 17.3%, and a return period of 5 years is 20.9%. The simulationÂ results showed the capacity of existing drainage channelsÂ for a return period of 2 years and 5 yearsÂ resulted in 8 channels overflowing from 42 existing channels with the number of injection wells needed as many as 45 injection wells for 8 water catchment areas. The effectiveness value of the application of injection wells using rain barrels obtained results forÂ a return period of 2 years isÂ 66.67%-93.33% with average injection well effectiveness is 84.66% andÂ a return period of 5 yearsÂ is 66%-95% with average injection well effectiveness is 84.78%.Â
Kajian Hidrolika Bangunan Pelimpah Samping (Side Channel Spillway) Bendungan Pomalaa Kabupaten Kolaka Provinsi Sulawesi Tenggara Dengan Uji Model Fisik 1:40
Authors: Paksi R. Susenatama Jatayu , Dermawan Very , Andawayanti Ussy
Published: September 2021

Pomalaa Dam designed to settle nickel mining wasted material ran by PT. Vale Indonesia, a physical model test is required to accomplish the design. This study aimed to determine the comparison of Pomalaa Dam side-channel spillway hydraulic condition between physical model test and theoretical analysis. In the analysis of the water level profile, debits of Q100th, Q1000th, and QPMF were examined. Spillway hydraulic analyzed by continuity equation with Cd calculation using the Iwasaki method. The water level in the transition channel and chute way calculated by the energy equation with the standard stage method. The side ditch and stilling basin hydraulic analyzed by momentum equations law. The vibration flow risk and cavitation respectively analyzed using Vendernikov-Montuori numbers and dimensionless parameters. The results of the hydraulic model test show that in the original design there is a non-uniform flow in the transition channel, the piezometer shows negative pressure in the chute channels section 2 and 3, but still safe. But the cavitation calculation using water velocity (v) and water depth (h) shows that cavitation occurred in the chute channels section 2 and 3 at the Q100th and Q1000th discharge and supercritical flow occurred at the end channel after the energy dissipator.
Studi Penerapan Manajemen Aset Irigasi pada Daerah Irigasi Nglirip Kabupaten Tuban
Authors: Kurniawan Decka Emeraldi , Prayogo Tri Budi , Wahyuni Sri
Published: September 2021

Irrigation asset management is required to maintain the condition and function of irrigation assets. The purpose of this study was to determine the priority of rehabilitated assets. As obtained from the results of the inventory survey, the amount of damage in the Nglirip Irrigation Area is 39 points. Physical condition assessment is carried out based on the guidelines of the Ministry of PUPR. Based on the calculation, the main building value is 85,08% (Good), carrier channel is 76,99% (Medium), the complementary building is 80,99% (Medium), Right Nglirip Primary Channel is 81,14 (Good) and Left Nglirip Primary Channel is 79,57% (Medium). The priority scale is calculated by sorting the smallest physical condition values and the AHP method. The order of priority scale based on the physical condition assessment is the carrier channel, Left Nglirip Primary Channel, complementary structure, Right Nglirip Primary Channel and the main structure. The order of priority scale using the AHP method is based on alternatives, the first order is the Right Nglirip Primary Channel, then the Left Nglirip Primary Channel. Meanwhile, based on the criteria, the first order is the carrier channel, the complementary structure and the main structure.