bluuebunny/crossref_metadata_2025 huggingface dataset:
Recuperation of Aircraft Gas Turbine Engines to Solve Problems Land Transport and Energy
Authors: Benmunach A. , Zanabili G. , Govorkov A.S.
Published: December 2022

The article presents an example of recuperation of aircraft gas turbine engines (GTE), adapted for use on ground conditions, used both for pipeline transportation of liquid, and gas forms which are oil or gas pipelines, and for power engineering. GTE due to its advanced qualities, such as compactness, specific energy intensity, throttle response, etc., have found a wide application in the form of power units for ground-based purposes. However, questions remain about their reliability and durability under these conditions, one of the approaches for solving these issues is the recuperation of the working process of the aircraft GTE. The paper presents a methodology for the implementation of a variant of the structural layout for recuperation of the power plant for the presented type. The principle of recuperation а GTE consists of the application of methods for converting, transferring, or redirecting heat in engine units Thus the goal of the presented work is to create a comparative methodology for mathematical modeling of the knownthermodynamic cycle of operation of a GTE and cycle with recuperation. The proposed research is aimed to study the option of using the energy of engine exhaust gases through a specially designed (selected) heat exchanger, the main work is the recognition and calculation of the actual state of the thermal potential in the engine, as well as the possibility of using the engine parameters averaged over the section to build a mathematical model for analyzing the performance of GTE cycles with or without heat recovery
TRABALHO, LUTAS SOCIAIS E RESISTÊNCIAS NA AMÉRICA LATINA
Authors: Durans Cláudia Alves , Tapiro Juan Pablo Sierra , Medina Walter Mauricio Gallego , Damasceno Wagner Miqueias Félix
Published: December 2022

Este artigo, fruto de uma Mesa coordenada apresentada na Joinp 2021, composta por 2 docentes colombianos e 2 brasileiros, busca discutir a atualidade do sistema capitalista e sua relação destrutiva com a natureza, que produz consequências dramáticas como doenças, epidemias e a pandemia da covid-19, tendo consequências profundas para a economia, na concentração e acumulação de riquezas e de aumento da pobreza, assim como, nas lutas de classes em várias partes do mundo, em especial na América do Sul. Traz uma análise da pequena mineração de ouro na Colômbia que representa 80% da produção anual de ouro e é marcada por relações de informalidade e "ilegalidade" típicas da estrutura econômica e política do país, condição que a torna uma expressão de trabalho vulnerável a ser capturada por capitais clandestinos, usurários e criminosos, que se encarregam de financiar e / ou extorquir as etapas da cadeia de valor, (extração, lucro e comercialização) e toda a complexidade e múltiplas sutilezas para encobrir a “ilegalidade” do ouro, lavar dinheiro e dar continuidade à rota de comércio internacional. Apresenta também aportes para entender el Paro Nacional de 2021 en Colombia, “como expresión de la crisis capitalista" e uma aproximação à maior mobilização social realizada nesse país durante o século XXI, entendido esse protesto como uma expressão da crise capitalista, na sua face mais imediata (na pandemia do Coronavírus COVID-19). Analisa ainda as lutas antirracistas na atualidade através do fenômeno recente que são as derrubadas das estátuas nos EUA e América Latina pelos movimentos sociais.
A QUARTA EXPRESSÃO DOS DIREITOS DE PERSONALIDADE: o conjunto informativo digital como um novo conceito no Direito Civil contemporâneo
Authors: Saldanha Rodrigo Róger , Oliveira José Sebastião de
Published: December 2022

A pesquisa aborda a necessidade de proteção de informações pessoais no âmbito digital, que devido aos avanços tecnológicos possibilita ao algoritmo utilizar um conjunto de informações que determinam nosso comportamento e intimidade. Nessa perspectiva, questiona-se se legislações vigentes e doutrina protegem o conjunto informativo da pessoa. Quanto a hipótese da pesquisa, apresenta-se relevante o surgimento da quarta expressão aos direitos de personalidade, necessário para ampliação da doutrina, mudança da jurisprudência e oportunidade legislativa. Sobre os objetivos, destaca-se a análise do algoritmo e sua interferência na personalidade humana na contemporaneidade, e a importância do anonimato como meio de proteção aos direitos de personalidade, onde verificou-se a possibilidade de classificar como quarta expressão o conjunto informativo digital. O método utilizado é o hipotético-dedutivo, utilizando-se de pesquisa doutrinária e legislativa, bem como em periódicos que circundam o tema
PESCA ARTESANAL E REGIMES DE USO COMUM DOS RECURSOS NO PARQUE NACIONAL DOS LENÇÓIS MARANHENSES
Authors: Mendes Diana Patrícia , Souza Filho Benedito
Published: December 2022

Este artigo busca compreender as regras que norteiam o uso de recursos comuns em combinação com a apropriação privada familiar, envolvendo a pesca artesanal praticada por famílias de comunidades tradicionais situadas no Parque Nacional dos Lençóis Maranhense, no município de Barreirinhas. Assim, tomando como referência a pesca artesanal, o trabalho procurará dar conta das regras que orientam a caracterização do regime de propriedade operado por famílias de comunidades tradicionais do PNLM, procurando refletir sobre o sentido de propriedade comum, uso comum dos recursos e apropriação privada familiar.
O diálogo entre a implementação da BNCC, a formação continuada de professores e as tecnologias digitais no cotidiano de uma escola de São Luís
Authors: Nascimento Ilma Vieira do , Borges Wendla Mendes Silva
Published: December 2022

Este trabalho, recorte de uma pesquisa desenvolvida no Programa de Pós-Graduação em Educação - Mestrado Profissional em Educação da Universidade Estadual do Maranhão (PPGE/UEMA), aborda a formação continuada como um dispositivo de implementação das prescrições da Base Nacional Comum Curricular – BNCC – em uma escola municipal da zona rural de São Luís-MA, por meio de um recurso tecnológico – o blog. Construído como um produto educacional, esse instrumento constituiu um espaço de escrita colaborativa com e entre os professores por ter sido um meio de comunicação e compartilhamento de materiais e ferramentas possibilitando, assim, a incursão nas orientações prescritas da BNCC , seus efeitos no trabalho pedagógico e , nesse processo, a formação continuada dos profissionais da escola, campo empírico da pesquisa original e onde se deu a construção daquela ferramenta tecnológica, essencial ao trabalho educacional em tempo de pandemia.
Effect of Salinity (NaCl) Stress on Root-shoot Traits of Tomato in Hydroponic Culture
Authors: Alam Md. Marju , Hossain Md. Mokter , Rabbani Md. Golam , Tasmim Mst. Tamanna , Rahman Lazia
Published: December 2022

Background: Tomato is one of the most important and popular vegetable crop grown mainly in dry seasons in Bangladesh. The southern part of the country is suffering from soil salinity problem due to tidal floods. The increasing salinity in the cultivatable land causes huge crop failure. A dozen of tomato varieties have been developed but they are not been tested for salinity tolerance. Therefore, this study was conducted to evaluate the tolerance level of tomato varieties against NaCl salinity stress at the vegetative stage. Methods: The study comprised of four levels of electrical conductivity (EC) based NaCl salinity viz., EC 2 (control), EC 4, EC 6 and EC8 mS/cm and eight varieties of tomato. The two-factor pot experiment was carried out in a randomized complete block design with four replications. NaCl salinity was imposed on the tomato plants through a hydroponic culture system and the effects of salinity on shoot-roots traits were measured. Result: Results showed that morphological traits of tomato plants varied significantly with the salinity levels and variety. It is also noticed that all the vegetative traits reduced as salt concentrations increased in the solution. In combined effects of variety and salinity levels, it was found that BARI Tomato-17 performed superior. It can be concluded that variety BARI Tomato-17 showed comparatively salt tolerant than the other varieties.
Role of Oxalic Acid in Expression of Resistance against the Pod Borer Helicoverpa armigera (Lepidoptera: Noctuidae) in Chickpea Varieties
Authors: Mishra Yogendra Kumar , Sharma Amit Kumar , Sondhia Shobha , Ramakrishnan R. Shiv , Panday A.K. , Gharde Yogita , Singh Sanjay
Published: December 2022

Background: Pod borer is most serious problem to cultivation of chickpea across the world. In India, Madhya Pradesh rank first in both area and production of chickpea. This region is considered most affected yield of chickpea due to H. armigera. Host plant resistance is an important component for managing this pest. To develop cultivars with resistance to insects, it is important to understand the role of oxalic acid associated with resistance to this pest. The current study aimed to study the role of oxalic acid in expression of resistance against the pod borer Helicoverpa armigera (Lepidoptera: Noctuidae) in chickpea varieties under climate change. Methods: This investigation was carried out at Research Farm of Soybean Seed Production-Unit, College of Agriculture, JNKVV (MP) during Rabi season 2019-20 and 2020-21. The field experiment was laid out in split split plot design with 24 treatments and three replications. The treatments included three date of sowing i.e. 15th November, 30th November and 15th December as a main plots, two irrigation levels i.e. I0-no irrigation and I1- irrigation at 35 DAS as a sub plots and four chickpea varieties i.e. JG 12, JG 36, JG 14 and JG 24 as sub sub plots. The observation on number of eggs and larval population of H. armigera were recorded from one-meter row length (mrl). At five randomly selected places were averaged separately for each plot and made in to number of eggs and larval population per meter row length (mrl). The amount of oxalic acid in chickpea leaves was determined by UFLC method. The correlation was worked out with population of pod borer and amount of oxalic acid in chickpea varieties. Result: In this investigation, the ultra-fast liquid chromatography (UFLC) profiles of the leaf exudates of chickpea varieties exhibited amounts of oxalic acid significantly negative correlation with egg count and larvae incidence of H. armigera.
Redistribution of gas between the bulk and bubble phases in water irradiated with low-intensity electromagnetic waves
Authors: Almazova Оlena , Lysychenko Mykola
Published: December 2022

It has been established that the irradiation of liquid water with low-intensity electromagnetic waves of the centimeters range provides:

Increasing the amount of light scattering (and optical density) of the water sample.

An increase in the volume of free air contained in the water.

These changes are due to the transfer of part of the gas dissolved in water into air bubbles.

The mechanism "bubble" can explain the effects of low-intensity electromagnetic waves on biological fluids. Also, a change in the "standard" mode of functioning of a living cell. Figs.:1, Tabl.:  , Refs.: 18 titles.

Keywords: electromagnetic waves, irradiation, air bubbles.
Method for determining the levels of detail of spatial objects as part of a three-dimensional information model of an urban area
Authors: Honcharenko Tetyana
Published: December 2022

The article proposes a method for determining the levels of detail for spatial objects, which is part of the three-dimensional information model of the urban area in order to reduce the computational load in operations related to visualization. The method adapts the concept of multi-level detailing to the list of spatial objects of the urban territory, where ranges of levels of detail are chosen for each of them, based on the needs of different management subjects when making decisions in emergency situations. Figs.: 4. Refs.: 14 titles.

Keywords: information model of the urban area, modeling of spatial objects, levels of detail, LoD; CityGML.
Generation of parallel colocation difference schemes using the integro-interpolation approach
Authors: Dmitrieva Olga , Huskova Vira
Published: December 2022

The issues of development of stable parallel difference schemes of a given order of accuracy, focused on the discretization of differential equations or their systems with concentrated and distributed parameters using an integro-interpolation approach to the generation of calculation coefficients, are considered. The proposed difference schemes improve the efficiency of parallel simulation and optimization of dynamic processes described by evolution equations with distributed parameters. Such equations are characterized by the absence of analytical solutions. The introduction of higher-order derivatives into difference schemes improves the accuracy of the obtained results and equalizes the approximation orders for all calculation points in the block.The proposed approach is universal for obtaining difference equations of various types. The computational formulas obtained on the basis of this approach for multipoint difference equations have less computational complexity and are oriented to implementation in computing systems with a parallel architecture.

Keywords: integro-interpolation approach, difference schemes, colocation block methods, parallel computing
Diagnosis and monitoring of a person's psychophysiological state based on multidimensional transient functions of the oculo-motor system
Authors: Pavlenko Vitaliy , Shamanina Tatiana , Chori Vladyslav
Published: December 2022

An important scientific and practical problem has been solved, which consists in the creation of methods and tools for nonlinear dynamic identification "input-output" of the human oculomotor system (OMS). Identification is carried out based on Volterra models in the form of multidimensional transient functions (n-dimensional integrals from Volterra kernels) using innovative eye tracking technology. As test signals, visual stimuli are used, which are displayed on the monitor screen at different distances from the starting position, which formally corresponds to the action of step signals with different amplitudes at the OMS input. Experimental studies of the OMS of individuals were carried out using the Tobii Pro TX300 eye tracker. The transient functions of the first and diagonal intersections of the transient functions of the second and third order were determined based on the data of oculographic studies. The models differ from the known ones in that they provide the possibility of modeling the OMS in each interval of input signals beyond the radius of convergence of the Volterra series. The obtained multidimensional functions are used as a source of primary data in the implementation of intelligent information technology for the diagnosis and monitoring of human psychophysiological states. A set of heuristic features are proposed, which are determined using integral and differential transformations of the obtained transient functions of the OMS. The informativeness of individual signs and all their possible combinations in pairs according to the indicator of the probability of correct recognition was studied. The research results were obtained using the construction of Bayesian classifiers in different spaces of the proposed features. Figs.: 2. Refs.: 15 titles.

Keywords: psychophysiological state, diagnosis, monitoring, oculo-motor system, identification, Volterra model, multidimensional transient functions, test visual stimuli, eye-tracking technology
Productivity Measurement Analysis Using American Productivity Center and Root Cause Analysis Method
Authors: Wulandari Pungky , Wahyuni Hana Catur
Published: December 2022

. PT Variasi Usaha Beton plant Pandaan in the mineral sector (BG) is one of the subsidiaries of PT Semen Indonesia Beton is engaged in the downstream industry of cement products. In production activities at PT Variasi Usaha Beton plant Pandaan in the mineral sector (BG) measures productivity by using the calculation of machine capacity per hour with units of tons per hour on the utility tool. With this calculation, the company only knows whether the company's production target has been achieved, but does not know the number of increases and decreases in productivity and profitability in the company. Given these problems, it is necessary to make systematic efforts through the measurement of overall productivity which consists of input costs of materials, labor, energy utilities, and capital using the American productivity center method and the root cause analysis method to determine the increase and decrease in productivity and profitability to determine actions. improvements to increase profits for the company. From the research results can be seen the value of productivity and profitability of PT Variasi Usaha Beton plant Pandaan business fluctuates up and down which is not constant. In the November period, productivity decreased in labor, raw materials, and energy inputs, while capital inputs experienced a decline in the February period. Meanwhile, the value of profitability experienced a decline in labor and capital inputs in the period of February, May, August, October, November, and December. For other month periods, it has increased. With these problems, companies need to stabilize and increase productivity by measuring, evaluating, and planning.
Hajj Pillars Education Application Using Markerless Augmented Reality Method
Authors: Hidayatullah Eka Fatra Arif , Dijaya Rohman , Azizah Nuril Lutvi
Published: December 2022

Hajj is a special worship, which is a dream and obligation for Muslims in the world to perform it, for those who are physically and materially capable. An introduction to the pilgrimage has been obtained since the 3rd grade of Elementary School (SD). The long process of the pilgrimage with various pillars and provisions contained in the procedures for its implementation often raises the disinterest of students in learning to understand and study the pilgrimage more deeply. To achieve the desired competence, many learning media have been developed, one of which is Augmented Reality (AR) technology. Augmented Reality (AR) is a technology that allows you to integrate 3D objects into a real environment. Based on this problem, the author makes an application about the introduction and pillars of the pilgrimage based on Augmented Reality using the Markerless method. Making applications using Blender software as a modeler and Unity 3D as an application maker. It is hoped that this application can introduce Augmented Reality into the world of education, and help students, especially elementary school children, get to know the pillars of Hajj better.
Besleyici Yönetici Davranışları Üzerine Nitel Bir Çalışma
Authors: BEKTAŞ Meral
Published: December 2022

Bu çalışmanın amacı besleyici yönetici davranışlarının genel olarak profilini çizerek, bireysel ve örgütsel etkilerini ortaya koymaktır. Nitel araştırma yöntemi kullanılarak fenomenolojik desende yürütülen çalışma verileri, yarı yapılandırılmış görüşme formu ile toplanarak betimsel analiz tekniği ile yorumlanmıştır. Elde edilen bulgular çerçevesinde besleyici yöneticilerin genel olarak çevrelerini koruyan, kollayan, destekleyen, problem çözen, öğrenen ve öğreten, kendini ve çalışanlarını koruyabilecek güçte davranışlar sergiledikleri ve besleyici yöneticilerin örgütsel ortamları olumlu olarak etkilediği görülmüştür. Ayrıca katılımcıların besleyici yöneticileri genel olarak çevrelerini koruyan kollayan kurtlara, destekleyen ve besleyen kraliçe arılara, asil görünen, liderlik yapan atlara, öğrenen ve öğreten kargalara, kendini ve çalışanlarını koruyabilecek güçte olan aslan ve kaplanlara benzettikleri görülmüştür. Kendi besleyici davranışları ile çalışanlarını besleyemeye çalışan besleyici yöneticilerin örgütlerdeki besleyici çalışanları yeterince desteklemeleri sonucunda besleyici çalışma ortamlarının oluşabileceği düşünüldüğü için bu çalışma ile öncelikle yöneticilere daha sonra ise çalışanlara bu konuda ışık tutularak, literatüre katkı sunulacağı düşünülmektedir.
Reflexões sobre a indissociabilidade do ensino, pesquisa e extensão a partir do projeto de ensino no curso técnico integrado ao ensino médio
Authors: Ribeiro Eduardo , Boligian Levon , Reinert Marcos
Published: December 2022

O presente relato de experiência abordará impressões de um  projetos de ensino executado na disciplina de Geografia dos primeiros anos dos cursos técnico integrado ao ensino médio no campus de São Francisco do Sul do Instituto Federal Catarinense (IFC)  com o tema  CENSO 2022. O projeto também propiciou vivenciar as etapas de uma pesquisa de campo e a realização de um evento de extensão. Todas as ações em sintonia com a discussão teórica sobre a indissociabilidade do ensino, pesquisa e extensão. Além de pontuar os referenciais teóricos que fundam este princípio, este relato também aborda a diferença entre a natureza de um projeto de ensino de um projeto integrado. O projeto de ensino é uma iniciativa pedagógica interessante e não é exclusiva a educação profissional e tecnológica. A experiência deve ser mais discutida e vivenciada no ensino básico como um todo.
Hyperlocal super-learned PM2.5 components across the contiguous US
Authors: Amini Heresh , Danesh-Yazdi Mahdieh , Di Qian , Requia Weeberb , Wei Yaguang , Abu-Awad Yara , Shi Liuhua , Franklin Meredith , Kang Choong-Min , Wolfson Jack , James Peter , Habre Rima , Zhu Qiao , Apte Joshua , Andersen Zorana , Xing Xiaoshi , Hultquist Carolynne , kloog Itai , Dominici Francesca , Koutrakis Petros , Schwartz Joel
Published: December 2022

Particulate matter with aerodynamic diameter less than 2.5 μm (PM2.5) increases mortality and morbidity.1,2 PM2.5 is composed of a mixture of chemical components that vary across space and time.3 Due to limited hyperlocal data availability, less is known about health risks of PM2.5 components, their US-wide exposure disparities, or which species are driving the biggest intra-urban changes in PM2.5 mass. Here, we developed the first national super-learned models across the US for hyperlocal estimation of annual mean elemental carbon (EC), ammonium (NH4+), nitrate (NO3-), organic carbon (OC), and sulfate (SO42-) concentrations across 3,535 urban areas at a 50-m spatial resolution, and at a 1-km resolution for non-urban areas from 2000 to 2019. Using ensembles of machine learning models and ~82 billion predictions across 20 years, hyperlocal super-learned PM2.5 components are now available for further research. We found remarkable spatiotemporal intra-urban and inter-urban variabilities in PM2.5 components. We anticipate our work to be a critical milestone for conducting new studies on individual and combined health risks of PM2.5 components, environmental justice analysis, or understanding fine-scale spatiotemporal variabilities of PM2.5 composition. Urban planners and regulators may also use these predictions for selecting locations of new daycares, schools, nursing homes, or air-quality monitors.
American Jatropha curcas L. accessions for crop improvement in biodiesel Production
Authors: Teco-Bravo Jalsen Iván , Mijangos-Cortés Javier Orlando , Barahona-Pérez Luis F. , Navarrete-Yabur Abelardo , Tovar-Juárez Edgar
Published: December 2022

In this study, the variation of morphological and agronomic characters of 10 accessions of J. curcas selected from Yucatan, Mexico, and Honduras was analyzed. The characters associated with the proportions of the plants (height, number, and length of branches), the fruits (diameter and thickness), and the seeds (length, width, and volume), as well as those associated with the agronomic yield (number and yield of seeds plant− 1), explained the greatest variation between the accessions, 40 and 24%, respectively. The CAM32 and GAGI10 accessions had the lowest vegetative proportions and the highest agronomic yield, SUCILATEBEC and B5F59P19 had the lowest proportion and low yield, B3F119P1 had the highest proportion and high oil content, but low yield; while B5F83P1 had high values of vegetative proportions, and agronomic performance. The characters with the greatest variation among the accessions were ABM (59.93%), WV (56.91%), NS plant− 1 (57.18%), the SY plant− 1 (55.49%), and NL (54.37%). The similarity analysis grouped the accessions that had in common the geographical origin and the magnitudes of the characters associated with the agronomic performance and with the proportions of the plants, fruits, and seeds. The present study allowed the identification of J. curcas accessions with desirable agronomic and morphological traits, such as seed yield, oil content, and plant height, which can serve as progenitors in breeding programs for this species.
The relationship between the neck and low back pain in association with gender
Authors: Baygutalp Fatih , Urak Faruk , Bilgic Abdulbaki , Kul Ayhan
Published: December 2022

Background: There are very few large population studies in Turkey that evaluate the risk factors associated with low back and neck pain in terms of gender. This study aimed to reveal the determinants of the co-occurrence of low back pain (LBP) and neck pain (NP) in terms of gender by synthesizing evidence regarding the risk factors of LBP and NP disease burden.
Methods: The study obtains the up-to-date 2019 Turkey Health Survey data from the Turkish Statistical Institute and covers 8163 families with 16253 individuals aged 18 and older. The dependent variable consisted of those who had neither LBP nor NP, had one, and had both, within the last 12 months using the random-effects ordered probit model.
Results: The 1-year total prevalence of LBP and/or NP in the Turkish population in 2019 was 39.49%. The dual burden of disease was 2.34 times higher in women than in men. In both sexes, the prevalence of dual disease increased significantly with increasing age and in the presence of severe obesity (P<0.05). When double disease prevalence in women compared with men, it was investigated that it was 2.49 times less common in unmarried people, 1.76 times less in those with a bachelor's degree, 1.79 times less in those who walked for more than an hour a day, and 2.83 times less in those who consumed one meal or more of fruit a day. As the monthly income of women increases, the probability of having a double disease decreases by 2.2 times compared to the probability of contracting a single disease. However, when the prevalence of double disease in women was compared with men, it was 3.94 times higher for the employed, 6 times higher for smokers, and 1.5 times higher for those with depression.
Conclusions: By disaggregating the data according to gender, statistical relationships between each group's LBP and NP burden and some risk factors were revealed to facilitate the treatment of modifiable risk factors.
Management of Large conjunctival cysts in a patient with Stevens-Johnson syndrome; a case report and review of the literature
Authors: Hooshmandi Sadid , Hassanpour Kiana , Veisi Amirreza , Movafaghi Vahid , Sadoughi Mohammad-Mehdi , Javadi Mohammad Ali
Published: December 2022

Background: To report the management of a patient with two conjunctival cysts as a late Stevens-Johnson syndrome (SJS) sequela. SJS is a life-threatening mucocutaneous disease with various etiologies including drugs, infections, and malignancies. Ocular manifestations of SJS vary from the membrane, symblepharon formation, and epithelial defect in the acute phase totrichiasis, eyelid margin keratinization, and lacrimal duct obstruction in the chronic phase.
Case presentation: A 13-year-old boy with a history of drug-induced SJS presented to our clinic complaining of a mass in the nasal side and inferior fornix of the right eye from 1 year ago. The mass-like lesion in the medial side of the right eye was accompanied by ankyloblepharon, symblepharon, and ptosis and limited ocular movement. Orbital imaging showed cystic lesions on the medial side of the right globe and the inferior fornix.
Two large cysts were entirely surgically excised. Histopathologic investigation revealed conjunctival tissue with nonkeratinized epithelium and goblet cells. There was no sign of conjunctival cyst recurrence or symblepharon formation on the 6th-month follow-up. The inferior fornix achieved acceptable depth and the ocular movements became normal.
Conclusion: Spontaneous conjunctival cysts may occur in SJS and should be managed carefully to improve the ocular surface and movements.
High-protein beverages, the impact on normalized protein catabolic rate and inflammation markers in a hemodialysis population: A study protocol for a double-blind randomized crossover design trial
Authors: Aycart Danielle Francesca , Andrade Jeanette
Published: December 2022

Background: Chronic kidney disease is considered a silent killer compared to more prominent non-communicable diseases such as cardiovascular disease and diabetes. In the final stage of this disease, end-stage kidney disease (ESKD), inflammation attributed to the presence of cytokines, acidosis and oxidative stress ensues, which contributes to other complications such as protein-energy wasting. In recent years, the kidney community has been focused on reducing this inflammation by recommending plant proteins compared to animal proteins. However, there is a lack of randomized clinical trials in the ESKD population, thus, recommendations of which proteins to consume are mixed.
Methods: A 12-week interventional, double-blind randomized controlled crossover clinical trial will be conducted to evaluate the impact 135g of whey (control) and 135g of soy (intervention) protein isolate beverages on protein status and inflammation in adults on hemodialysis. A simple randomization method will indicate which protein source the participants will receive first. Baseline data collections will be conducted after participant allocation but before the participant consumes the beverage. The first beverage will be provided to the participants after every dialysis treatment for 4-consecutive weeks. The participants will then have a 4-week washout period to avoid carryover effect. After the washout period has concluded, the second beverage will be provided for 4-consecutive weeks. The primary outcome is impact on inflammation as detected by serum C-reactive protein from baseline to post-intervention. Secondary outcomes are the differences in estimated normalized protein catabolic rate and interleukin 6. Exploratory outcomes include detection in amino acids, differences in uremic toxins, dietary habits as identified through a food frequency questionnaire and malnutrition as detected by the malnutrition inflammation scores from baseline to post-intervention.
Discussion: If the soy protein isolate beverage improves protein status and reduces inflammation, this study will have major clinical implications for providing plant-based proteins within the ESKD population to help mitigate complications.
Trial registration: This study was registered in ClinicalTrial.gov on February 7, 2022, identifier NCT05227755.
Pharmacokinetic and safety analysis of biosimilar adalimumab in healthy volunteers in Bangladesh
Authors: Kulsum Umme , Azad Kasrina , Washif Mubasshir , Hossain Mohabbat , Sultana Nishat , Hossain Ismail , Ahmed Faez , Rahman Ridwanur , Muktadir Abdul , Muktadir Hasneen , Karim Mahbubul , Rahman Mohammad Mizanur , Hossain Md Shawkat , Monim Syed Abdul , Panday Alex S. , Qadri Firdausi , Kawser Zannat
Published: December 2022

Aims
Advixa is a monoclonal antibody manufactured as a biosimilar to adalimumab (Humira, Abbvie Inc.). The key objectives of this study were to use a healthy population group to assess pharmacokinetics (PK) and safety similarity between Advixa and Humira in healthy participants and to quantify the effects of potential covariates on adalimumab PK and safety to assess the impact of treatment with Advixa.
Methods
A group of healthy participants selected by screening aged between 18 and 45 years. According to the randomization table, each participant was given Adalimumab (Advixa and Humira) in the inpatient facilities in a hospital and observed for 72 hours. Several blood samples were collected from the participants at different time points up to day 64 to measure their Pharmacokinetics and biosimilarity.
Results
The serum concentration-time profiles for PK and safety were compared in this randomized, double-blinded study between Humira and Advixa. A review of the data for biosimilarity confirmed that these products are similar to each other regarding healthy participants. 90% confidence interval of the relative mean Cmax, AUC0-t, and AUCo-inf of the Advixa and Humira were found within the acceptance criteria. No differences in safety profiles were observed in these studies.
Conclusion
PK and safety are similar between Advixa and Humira in participants with healthy status demonstrated in this clinical trial (NCT05172817; Registration Date/Initial Release Date: 28/09/2021). Adalimumab PK was also similar to treatment with Humira and Advixa.
An Insight of AZ91D/WS2 Surface Composite developed by FSP
Authors: Sathiskumar M. , Kamaraj M.
Published: December 2022

The authors have requested that this preprint be removed from Research Square.
Dual novel homozygous mutations in ISG15 and MPO lead to classic type I interferonopathy and a new phenotype of recurrent parenchymal pneumonia
Authors: Xu Qiling , Li Wenyan , zhao Qian , Lv Ge , Sun Gan , Gao Yelei , Ding Yuan , Zhang Zhiyong , Zhou Lina , Tang Xuemei , Zhao Xiaodong , An Yunfei
Published: December 2022

Purpose
ISG15 deficiency, a rare human inborn error of immunity characterized by susceptibility to Mycobacterium tuberculosis infection, shows neuropathic and dermatological manifestations. MPO deficiency is a common inherited defect of phagocytes, but it is not classified as an independent primary immune deficiency due to lack of clinical symptoms. Dual mutation of ISG15 and MPO has not been reported.
Methods
We analyzed the clinical, genetic, and immunological features of two siblings with ISG15 deficiency combined with MPO mutations, and explored therapeutic candidates.
Results
The major manifestation observed in patient 2 was necrotic skin lesions, while those in patient 1 were intracranial calcification and recurrent pneumonia. Whole-exome sequencing indicated novel, dual mutations in ISG15 and MPO, leading to lack of ISG15 expression and reduced MPO expression. PBMCs and B-cell lines derived from the patients showed hyperactivated JAK/STAT signaling and elevated oxidative stress. A "False-Positive" DHR test for MPO was reversed by exogenous peroxidase. RNA sequencing analyses identified baricitinib as an available therapeutic candidate for hyper-inflammation associated with ISG15 deficiency.
Conclusions
We reported two sibling patients with the same novel ISG5 mutation combined with partial MPO deficiency. These patients showed different presentations, and one of them harbored a new phenotype of recurrent pneumonia. These findings expand the clinical spectrum of ISG15 deficiency, reinforce its diversity, and identify a potential therapeutic candidate for this rare disease.
Simultaneous adsorption of Amoxicillin and Cefixime by facile synthesized Chitosan@Polyacrylamide@ZIF-8; Isotherm and Kinetic study
Authors: Zadvarzi saber Babaee , Amooey Aliakbar
Published: December 2022

In recent years, drug use around the world due to population growth and the spread of disease is increasing these include antibiotics which account for about 10 to 15% of drug use. The studies show that antibiotics have a permanent and destructive effect on the environment which not completely removed in refineries. In this study, the Chitosan@Polyacrylamide@ZIF-8 as an adsorbent was simultaneously used to removal of Cefixime and Amoxicillin from the aqueous solution by adsorption method. XRD and FTIR patterns were analyzed for investigation of the surface crystallinity and the chemical properties of the adsorbent. In the following, SEM and TEM images were used for surface morphology study. Finally, a numerical investigation have been done for predicting the adsorption effective parameters. The results show that pH 4, contact time 30 minutes, initial concentration 50 mg/L, temperature 25° C and 15 mg of adsorbent are optimal condition which removal percentage achieved up to %90. The Langmuir, Friendlich, Tamkin, and Dubinin-Radushkovich isotherms were examined by experimental data and Langmuir model presented the best consistency with the experimental results and the maximum calculated adsorption capacity for Amoxicillin and Cefixime are 910 mg/g and 588 mg/g, respectively. Pseudo-first order, Pseudo-second order and intra-particle diffusion were investigated for kinetic studies. The results of the calculations illustrated the Pseudo second order model has been dominant. Overall, this study expresses, Chitosan@Polyacrylamide coated by ZIF-8 can be used an appropriate, effective and economical adsorbent for the adsorption of Amoxicillin and Cefixime.
Simbolisme Tradisi Nyadran Desa Sonoageng sebagai Media Pengayaan Materi Pembelajaran Sastra Siswa SMA di Kabupaten Nganjuk
Authors: Ramdani Putra Chelya Ilham , Puspitoningrum Encil , Sujarwoko Sujarwoko
Published: December 2022

Literature learning is an important part of learning that must be taught to students. Literature can provide benefits and form a good personality in students. This writing aims to find out the benefits of enriching literary learning materials through local culture which in this case is the traditional symbolism of nyadran. From this writing, the concept of symbolism of the nyadran tradition is found, namely for individuals which include the values of 1) willing to sacrifice, 2) responsibility, 3) obedience, and social meaning which includes the values of 1) mutual cooperation, 2) mutual respect. From this it is expected that students are able to have this attitude and have a superior personality. Thus, it can be concluded that the enrichment of literary learning materials through local culture needs to be done.
Analisis Kesalahan Berbahasa (Tulis) Pemelajar BIPA Level 7 dalam Pembuatan Karya Ilmiah
Authors: Jannah Azka Nidaul , Khaerunnisa Khaerunnisa
Published: December 2022

This study aims to describe written language errors of level 7 BIPA students in writing scientific papers, including errors in (1) conjunctions, (2) capital letters, (3) puntuations,  and (4) sentences structure.  The data used in this study were three BIPA level 7 scientific papers. The method used was descriptive-qualitative. Data analysis was carried out by  (1) note things that are aspects of language errors, (2) classify language errors into certain groups, and (3) describe those language errors. The result of the study show that in the scientific papers of BIPA level 7 students there are still many errors, including errors in using conjunctions at the beginning of sentences, inaccuracies in the use of capital letters which are often placed in the middle of sentences, inaccuracies in the use of comma and full stop punctuation, and sentence ineffectiveness triggered by structural interference sentences in foreign languages, redudant words, and incomplete sentence patterns.
Relevansi Nilai Moral dalam Antologi Cerpen Pacar Seorang Seniman Karya W. S. Rendra pada Pembelajaran Sastra
Authors: Julianto Indra Rasyid , Umami Annisa Sauvika
Published: December 2022

This article aims to explain the moral aspect in the short story anthology of Pacar Seorang Seniman by W. S. Rendra. This research uses short stories in the anthology of Pacar Seorang Seniman by W. S. Rendra using an analytic descriptive method with a qualitative approach. A pragmatic approach is used to deep review Rendra's 186-pages anthology which was published in its first printing, October 2016. The data collection used in this research is the reading and note-taking technique. The results of the study show that in this anthology there are moral values related to oneself, moral values among humans, humans and God, and humans and nature. Many moral values are conveyed by the author in the collection of Pacar Seorang Seniman short stories, either through the author's description or dialogue between the characters. This is applied as a means for cultivating the noble  characters as stated in the 2013 Curriculum. The short story collections of Pacar Seorang Seniman has met the criteria for literary appreciation materials so that it is appropriate to be used as the appreciation materials for learning prose at the high school level, that is the analyzing values in literary works.
In Vitro Cytotoxicity Analysis of Bioceramic Root Canal Sealers on Human Gingival Fibroblast Cells
Authors:   Department of Biotechnology, Kulliyyah of Sciences, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia, Ja’apar Siti Aisyah Nadirah , Ichwan Solachuddin Jauhari Arief ,   Dentistry Programme, Pengiran Anak Puteri Rashidah Sa’adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Jalan Tungku Link, BE1410 Brunei Darussalam, Mustaffa Musliana ,   Department of Restorative Dentistry, Kulliyyah of Dentistry, International Islamic University Malaysia, 25200 Kuantan, Pahang, Malaysia
Published: December 2022

This study evaluated the cytotoxicity of four bioceramic root canal sealers (bioceramic sealers): GuttaFlow Bioseal (GB), MTA Fillapex, CeraSeal Bioceramic root canal sealer (CS), and iRoot SP root canal sealer (iRSP). The viability of human gingival fibroblast (HGF) cells was used to evaluate the cytotoxicity of these bioceramic sealers. HGF cells were cultured and exposed to bioceramic sealer extracts for 24 hours, 48 hours and 72 hours at 37°C in an incubator humidified with 5% CO2. The 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide or MTT assay was conducted to determine cell viability at each incubation period and compared among all bioceramic sealers. The Kruskal-Wallis test revealed statistically significant differences between the positive control group and MTA Fillapex, MTA Fillapex and GB, and between GB and iRSP with p < 0.05. However, no statistical differences were found in cell viability for each material across all the incubation periods. GB was the least cytotoxic bioceramic sealer with cell viability exceeding 90% throughout the 72-hour incubation followed by CS, iRSP, and MTA Fillapex with non-cytotoxicity after 72-hour incubation, mild cytotoxicity after 72-hour incubation, and mild cytotoxicity after 72-hour incubation, respectively. However, iRSP showed moderate cytotoxicity, and MTA Fillapex was severely cytotoxic (< 30% cell viability) after 24-hour incubation.
In Vitro Evaluation of Human Demineralised Teeth Matrix on Osteogenic Differentiation of Gingival Mesenchymal Stem Cells
Authors:   Department of Oral and Maxillofacial Surgery, AB Shetty Memorial Institute of Dental Sciences, Nitte University, Deralakatte-575018, Mangaluru, India, Deshpande Dhanashree , Karikal Arvind ,   Department of Oral and Maxillofacial Surgery, AB Shetty Memorial Institute of Dental Sciences, Nitte University, Deralakatte-575018, Mangaluru, India, Kumar Chethan ,   Nitte University Centre for Stem Cell Research and Regenerative Medicine, KS Hegde Medical Academy, Nitte University, Deralakatte-575018, Mangaluru, India, Kumar Basavarajappa Mohana ,   Nitte University Centre for Stem Cell Research and Regenerative Medicine, KS Hegde Medical Academy, Nitte University, Deralakatte-575018, Mangaluru, India, Shetty Veena ,   Nitte University Centre for Stem Cell Research and Regenerative Medicine, KS Hegde Medical Academy, Nitte University, Deralakatte-575018, Mangaluru, India
Published: December 2022

The use of tooth-derived material as a scaffold has gained attention recently due to its ease of availability and bioactive properties. Hence, the objective of this study was to determine in vitro interaction of human gingival mesenchymal stem cells (hGMSCs) with human demineralised teeth matrix (hDTM) on osteogenic potential with or without osteogenic inducers. The hGMSCs were established and characterised on their morphology, proliferation, population doubling time (PDT), viability, colony-forming ability, expression of cell surface markers and adipogenic differentiation. Further, the effect of hDTM on the biocompatibility and osteogenic differentiation ability of hGMSCs was evaluated. The hGMSCs displayed a fibroblast-like appearance and exhibited a greater proliferative activity. The cells showed > 91% viability, and PDT varied between 39.34 hours and 62.59 hours. Further, hGMSCs indicated their propensity to form clusters/ colonies, and expressed the markers, such as CD29, CD44, CD73 and CD90, but were negative for CD34 and CD45. When treated with adipogenic induction medium, hGMSCs were able to exhibit the formation of neutral lipid vacuoles. The hGMSCs cultured with hDTM did not show any cytotoxic changes including morphology and viability. Mineralisation of calcium nodules was observed in hGMSCs when cultured in osteogenic induction (OI) medium as an indication of osteogenesis. hGMSCs when cultured with hDTM confirmed the presence of a mineralised matrix. Further, when the cells were cultured with hDTM along with OI, they showed slightly enhanced differentiation into osteocytes. In conclusion, hGMSCs were shown to be biocompatible with hDTM, and demonstrated their enhanced osteogenic potential in the presence of hDTM and osteogenic supplements.
AUTOMATIC RELATION EXTRACTION BETWEEN ENTITIES FOR AMHARIC TEXT
Authors:   Assistatnt Professor, Department of Computer Science, Ambo University, Ethiopia., Nagarajan S. , Genet Melkamu ,   Lecturer, Department of Computer Science, BuleHora University, Ethiopia., Negesa Yonatan ,   Lecturer, Department of Computer Science, Werabe University, Ethiopia.
Published: December 2022

This research work primarily focused on the automatic relation extraction between entities for Amharic text using supervised machine learning approach.The Walta Information Centre online archive resources were used to create the studys own corpus, which consisted of 2000 sentences and a reasonable quantity of 30,466 words or tokens. The proposed solution has four processes namely preprocessing, Text labeling, feature extraction and feature selection and Recognition. The tokenization and POS are used as preprocessing. After the text is tokenized and giving POS for each of tokens the next step is text labeling system. For text labeling mechanism BIO scheme is used. The tag features are selected for building the model. The Tag feature consists of name entity type and relation type. The name entity type features are represented by Location (LOC), Organization (ORG) and Person (PER) and the relation type features are identified every word which existed between two entities for instance between location-location relation type or location-organization relation type and all the corresponding entities that are appeared it. Vectorizations are done using DictVectorizer and word2features. Support vector machines and conditional random field machine learning are used to for recognizing the entity relation between Amharic texts. SVM with SGD achieved the weighted precision of 49%, recall 10% and f1-score 13% are scored. SVM with Multinomial Naive Bayes Classifier Algorithm achieve precision of 61%, recall 41% and f1-score 48%.SVM with Passive Aggressive classifier achieved weighted average precision of 55%, recall 19% and f1-score 27%. CRF algorithm achieved precision of 87%, recall 87% and f1-score 86%. The CRF model outperform compared with other SVM algorithms.