bluuebunny/crossref_metadata_2025 huggingface dataset:
V-042 MOVING THE CONCEPT ASSOCIATED TO LAPAROSCOPIC INTRACORPOREAL RECTUS APONEUROPLASTY (LIRA) TO LATERAL HERNIA
Authors: Licardie E , Gómez P , Navarro L , Bellido A , Gómez-Menchero J , Morales-Conde S
Published: October 2022

Aims

Lateral hernias(LH) are rare and there are difficulties associated to minimally invasive approach, LIRA-technique has been described as an alternative to simple closure of the defect. Despite this, the indications of the concept associated to this technique are beginning to expand to other complex locations. Aims of this video is to show the surgical steps for LH where the concept associated to LIRA is followed to repair this type of hernias.

Material & Methods

56-year-old female patient without previous surgical history. Clinical examination and CT-scan showed a LH(L2) 6.4 cm in width(W2) and a length of 6.6 cm.

Results

We started by opening the peritoneum and fascia, exposing the fibers of the internal oblique and the posterior rectus sheath near the border of the defect. Then, the peritoneum and the fascia transversalis, and medially the posterior aponeurosis of the rectus muscle, are opened. Also, it is important to create a lateral peritoneum flap, using a hybrid procedure that involves a partially extraperitoneal and transabdominal (TAPE), then loop-suture are used for closing the defect. Finally, the mesh is placed intraperitoneally and partially extraperitoneal.

Conclusions

Best surgical technique for LH is still not clear. The anatomical location of these hernias is challenging, recurrence and bulging are also frequent. Since the introduction of the concept of primary closure of the hernia defect, the surgical repair of hernias in different locations has changed, although the idea of expanding the indication of LIRA could be related to better results in term of recurrences, bulging and pain.
Prefrontal and somatosensory-motor cortex effective connectivity in humans
Authors: Rolls Edmund T , Deco Gustavo , Huang Chu-Chung , Feng Jianfeng
Published: October 2022

Effective connectivity, functional connectivity, and tractography were measured between 57 cortical frontal and somatosensory regions and the 360 cortical regions in the Human Connectome Project (HCP) multimodal parcellation atlas for 171 HCP participants. A ventral somatosensory stream connects from 3b and 3a via 1 and 2 and then via opercular and frontal opercular regions to the insula, which then connects to inferior parietal PF regions. This stream is implicated in “what”-related somatosensory processing of objects and of the body and in combining with visual inputs in PF. A dorsal “action” somatosensory stream connects from 3b and 3a via 1 and 2 to parietal area 5 and then 7. Inferior prefrontal regions have connectivity with the inferior temporal visual cortex and orbitofrontal cortex, are implicated in working memory for “what” processing streams, and provide connectivity to language systems, including 44, 45, 47l, TPOJ1, and superior temporal visual area. The dorsolateral prefrontal cortex regions that include area 46 have connectivity with parietal area 7 and somatosensory inferior parietal regions and are implicated in working memory for actions and planning. The dorsal prefrontal regions, including 8Ad and 8Av, have connectivity with visual regions of the inferior parietal cortex, including PGs and PGi, and are implicated in visual and auditory top-down attention.
Unitary synaptic responses of parvalbumin interneurons evoked by excitatory neurons in the mouse barrel cortex
Authors: Canales Alejandra , Scheuer Katherine S , Zhao Xinyu , Jackson Meyer B
Published: October 2022

The mammalian cortex integrates and processes information to transform sensory inputs into perceptions and motor outputs. These operations are performed by networks of excitatory and inhibitory neurons distributed through the cortical layers. Parvalbumin interneurons (PVIs) are the most abundant type of inhibitory cortical neuron. With axons projecting within and between layers, PVIs supply feedforward and feedback inhibition to control and modulate circuit function. Distinct populations of excitatory neurons recruit different PVI populations, but the specializations of these synapses are poorly understood. Here, we targeted a genetically encoded hybrid voltage sensor to PVIs and used fluorescence imaging in mouse somatosensory cortex slices to record their voltage changes. Stimulating a single visually identified excitatory neuron with small-tipped theta-glass electrodes depolarized multiple PVIs, and a common threshold suggested that stimulation elicited unitary synaptic potentials in response to a single excitatory neuron. Excitatory neurons depolarized PVIs in multiple layers, with the most residing in the layer of the stimulated neuron. Spiny stellate cells depolarized PVIs more strongly than pyramidal cells by up to 77%, suggesting a greater role for stellate cells in recruiting PVI inhibition and controlling cortical computations. Response half-width also varied between different excitatory inputs. These results demonstrate functional differences between excitatory synapses on PVIs.
Evaluation and management of cancer patients presenting with acute cardiovascular disease: a Clinical Consensus Statement of the Acute CardioVascular Care Association (ACVC) and the ESC council of Cardio-Oncology—part 2: acute heart failure, acute myocardial diseases, acute venous thromboembolic diseases, and acute arrhythmias
Authors: Gevaert Sofie A , Halvorsen Sigrun , Sinnaeve Peter R , Sambola Antonia , Gulati Geeta , Lancellotti Patrizio , Van Der Meer Peter , Lyon Alexander R , Farmakis Dimitrios , Lee Geraldine , Boriani Giuseppe , Wechalekar Ashutosh , Okines Alicia , Asteggiano Riccardo , Combes Alain , Pfister Roman , Bergler-Klein Jutta , Lettino Maddalena
Published: October 2022

Advances in treatment, common cardiovascular (CV) risk factors and the ageing of the population have led to an increasing number of cancer patients presenting with acute CV diseases. These events may be related to cancer itself or cancer treatment. Acute cardiac care specialists must be aware of these acute CV complications and be able to manage them. This may require an individualized and multidisciplinary approach. The management of acute coronary syndromes and acute pericardial diseases in cancer patients was covered in part 1 of a clinical consensus document. This second part focusses on acute heart failure, acute myocardial diseases, venous thromboembolic diseases and acute arrhythmias.
Farm Advisory Services and total factor productivity growth in the Irish dairy sector
Authors: Parikoglou Iordanis , Emvalomatis Grigorios , Thorne Fiona , Wallace Michael
Published: October 2022

This paper investigates the impact of the engagement of individual farmers with Farm Advisory Services (FAS) on total factor productivity (TFP) growth, as a relevant indicator of competitiveness under the vision of sustainable intensification. Using farm-level data from the Irish dairy sector between 2008 and 2017, we estimate a random-coefficients stochastic frontier model and construct a TFP growth index, extending Orea (2002) such that the contribution of FAS becomes an additional component of the index. The results indicate that the main driver of TFP growth was technical change and efficiency gains; a negative scale effect slowed down TFP growth, but this impact was counteracted by the positive contribution of FAS to productivity growth.
Prevalence of transthyretin amyloidosis in patients with heart failure with preserved ejection fraction
Authors: Naito T , Nakamura K , Abe Y , Sakuragi S , Kihara H , Okizaki A , Kawai Y , Watanabe H , Yoshikawa M , Takaishi A , Fujio H , Otsuka H , Ogura S , Nomura N , Ito H
Published: October 2022

Background

Heart failure with preserved ejection fraction (HFpEF) currently accounts for up to half of heart failure cases. Although transthyretin amyloidosis (ATTR) can cause HFpEF, the contribution of ATTR to the burden of HFpEF is poorly defined.

Purpose

To clarify the characteristics of ATTR and determine the prevalence of cardiac ATTR in patients with HFpEF.

Methods

This is a multicentre, prospective, observational study in Japan. We enrolled 373 HFpEF (HF+LVEF ≥50%+ 65 < years old) patients who admitted to the Departments of Cardiology from September 2018 to January 2022. A 99mTc-PYP scintigraphy was performed during admission in all eligible patients. The patients divided into 2 groups according to 99mTc-PYP scintigraphy positive (Grade2–3: n=53) or negative (Grade 0–1: n=320). Medical history, laboratory data, echocardiogram, hemodynamic data, treatments compared.

Results

A total of 55 patients (14.2%) showed a moderate to severe up take on the 99mPYP scintigraphy. An endomyocardial biopsy was performed in 32 patients confirming amyloidosis in all cases. There were no differences in age, gender, diabetes, coronary artery disease between the two groups. Although patients with positive PYP group exhibited higher N-terminal pro-brain natriuretic peptide [3.0 (1.7–4.6) vs 3.4 (2.4–4.2); P<0.001)], high sensitive troponin T (0.035±0.038 vs 0.074±0.049; P<0.001), mean left ventricle maximal wall thickness (10.5±1.9 vs 12.5±2.2; P<0.001), clinical overlap between ATTR and other HFpEF forms was high.

Conclusion

ATTR is a disease with significant prevalence in Japanese patients with HFpEF

Funding Acknowledgement

Type of funding sources: None.
Relationship between GDF-15, urinary sodium and markers of renal function in patients with chronic heart failure
Authors: Moreira G R , Avila D X , Di Candia A M , Scaramussa V D , Cavaliere N C , Martins F T , Vieira M P , Villacorta H
Published: October 2022

Background

Patients with heart failure (HF) often have altered renal function. Urinary sodium is a marker of diuretic resistance and is associated with a worse prognosis in HF. Growth differentiation factor-15 (GDF-15) is a marker of oxidative stress and inflammation and is a prognostic predictor in HF.

Objectives

We sought to assess the relationship of GDF-15 with renal function parameters and with urinary sodium in patients with chronic HF.

Methods

We undertook a cross-sectional study of patients with HF from specialized outpatient clinic. Patients with signs and symptoms of HF and LVEF <50% were included. An echocardiogram was performed and blood samples were collected, which were frozen for the final study, where the performance of GDF-15 in the prediction of renal outcomes in HF will be evaluated. The dosage of NT-proBNP was performed using the Elecsys® system (Roche, Basel, Switzerland) and GDF-15 by the sandwich immunoassay method with monoclonal antibodies (Elecsys®, Roche, Basel, Switzerland). Analysis of the relationship between GDF-15 and baseline renal parameters was performed. Correlation analysis was performed between GDF-15 and continuous variables, using the Spearman method.

Results

Sixty-seven patients were included. The etiologies of HF were hypertension, diabetes mellitus, alcoholic cardiomyopathy and idiopathic cardiomyopathy. Forty-one (61.2%) individuals were male, with a mean age of 61±13 years. Median GDF-15 values were 1413 pg/mL (interquartile range 1044–2554). Patients with GDF-15 values above the median had lower urinary sodium values (88 mEq/L [53–121] vs 112 [76–171], p=0.06), lower glomerular filtration rate (GFR) (63.9±29.1 vs 91.2±25 mL/min/1.73 m2, p=0.001) and higher creatinine levels (1.32 mg/dL [0.85–1.71] vs 0.91 [0.78–1.08], p<0.001). There was no significant difference in relation to urinary albumin (21 mg/L [7–126] vs 15.1 [5.8–41], p=0.30). The urinary albumin/creatinine ratio was higher in the group above the median, but did not reach statistical significance (38 mg/g [11–110] vs 12.5 [4.9–29], p=0.13). There was a direct correlation between GDF-15 and creatinine (r=0.56, p<0.001) and an inverse correlation with urinary sodium (r=−0.39, p=0.005) and with GFR (r=−0.55, p<0.001).

Conclusion

GDF-15 correlated with lower urinary sodium levels and worse kidney function in patients with chronic HF. Future studies should address whether GDF-15 is a predictor of worsening renal function overtime.

Funding Acknowledgement

Type of funding sources: None.
From sounding the tocsin to ringing the doorbell: some reflections on Saint Bartholomew as a neighbourhood massacre
Authors: Foa Jérémie
Published: October 2022

What do we know, after so many pages devoted to the lieu de mémoire ‘Saint-Barthélemy’, of the thousands of Protestants thrown into the Seine or flung into the Saône, of those anonymous men, women and children exterminated in the summer and autumn of 1572? What do we know about the executioners during those nights, about those rare people who put their heart and soul into massacring their Huguenot neighbours? The responsibility of Catherine de Médicis or the Guise has been the subject of much interest; the torments of Charles IX and Spanish manipulation have long been scrutinized. This article will eschew these legitimate investigations in order to focus on the humble lives behind that night, the faces of the victims and the names of the killers, to discover who the ordinary actors were in this extraordinary event.
Individual and Societal Shortcomings in Eighteenth-Century German Comedy: A Reassessment
Authors: Wagner Martin
Published: October 2022

To what extent do comedies place the blame for vicious behaviour on the individuals who fail to comply with the norms of their society, or on the structures of society in which individuals act? The traditional understanding is that the moral-philosophical critique of individual behaviour in older comedy was supplanted by social criticism in newer comedy. This article revisits the history of comedy to emphasize the very gradual nature of this development and to shed light on the nuances in the distinction between the critique of individuals and the critique of social structures. The argument is developed through an exemplary analysis of four German-language plays from the eighteenth century: the comedies Die ungleiche Heirath (1743) by Luise Gottsched, Der geschäfftige Müssiggänger (1743) by Johann Elias Schlegel, and Die Soldaten (1776) by J. M. R. Lenz, as well as the farce Voltaire am Abend seiner Apotheose (1778) by Heinrich Leopold Wagner.
Acetamiprid used to preventHylobius abietisdamaging young trees poses a very low risk of causing water contamination provided good forestry practices are followed
Authors: Thomas H , Nisbet T R , Willoughby I H
Published: October 2022

A study of chemical runoff following the use of acetamiprid as a pre-treatment and top-up spray to prevent damage from the large pine weevil (Hylobius abietis L.) to young trees was undertaken at a restock site in mid-Wales. The site was specifically selected to pose a high risk of chemical runoff, being a high elevation, headwater catchment with stagnopodzol soils, subject to high rainfall. Water samples were collected before, during and after each treatment from six points around the site, as well as from a nearby stream that acted as a control. Only 1 of the 90 water samples collected detected acetamiprid at levels above the limit of quantification of 0.005 μg l−1 (i.e. 0.000000005 g in 1 l of water) and this appeared to be due to wash-off of residues from the plastic bags the trees had been delivered to the site in, which had been temporarily placed within a dry road drain. The recorded concentration of 0.1022 μg l−1 of acetamiprid was low, being only 20 per cent of the Predicted No Effect Concentration (PNEC) of 0.5 μg l−1. Neither of the top-up spray applications resulted in water contamination at any of the sampling points. The results show that the good forestry practice measures employed were effective in preventing contamination of stream waters by acetamiprid. The use of 10-m buffers between forest drains and receiving streams, as per standard good forestry practice in the UK, should be more than adequate to prevent any chemical runoff contaminating watercourses. However, it is recommended that forest practice is further tightened in relation to the placement and handling of planting bags on site. Bags should not be placed within or near road or forest drains, and they should be removed from the site at the end of each day.
Tectonic deformation at the outer rise of subduction zones
Authors: Yang Jianfeng , Zhao Liang , Li Yang
Published: October 2022

Fluids associated with subducting slabs play a crucial role in regulating the dynamics of water discharge, subsequent arc magmatism and intermediate-depth earthquakes in subduction zones. The incoming slab mantle hydration is primarily determined by deep normal faulting due to plate bending at the trench. However, the controlling factors on the outer rise faulting pattern, and the correlation between the inherited outer rise deformation and the intermediate-depth earthquakes, remain to be understood. Here we present high-resolution viscoelasto-plastic numerical models of free subduction for slab bending-related faulting prior to subduction. Our model results show that plastic weakening and friction coefficient of the slab mantle exhibit a significant impact on fault pattern, while plate age and elasticity have a minimal bearing for mature slabs. The brittle bending faults result in large positive pressure gradients in the vertical direction, facilitating seawater infiltrating into the subducting slabs, which corroborates previous numerical models. The faults reaching 15–30 km beneath the Moho coincide with the width of the double seismic zone in subduction zones. We anticipate that water pumped into the slab mantle along the faults, with decreasing water content along the depth, can explain the relatively sporadic lower plane earthquakes.
Optimal stacking of noise cross-correlation functions
Authors: Yang Xiaotao , Bryan Jared , Okubo Kurama , Jiang Chengxin , Clements Timothy , Denolle Marine A
Published: October 2022

Cross-correlations of ambient seismic noise are widely used for seismic velocity imaging, monitoring and ground motion analyses. A typical step in analysing noise cross-correlation functions (NCFs) is stacking short-term NCFs over longer time periods to increase the signal quality. Spurious NCFs could contaminate the stack, degrade its quality and limit its use. Many methods have been developed to improve the stacking of coherent waveforms, including earthquake waveforms, receiver functions and NCFs. This study systematically evaluates and compares the performance of eight stacking methods, including arithmetic mean or linear stacking, robust stacking, selective stacking, cluster stacking, phase-weighted stacking, time–frequency phase-weighted stacking, Nth-root stacking and averaging after applying an adaptive covariance filter. Our results demonstrate that, in most cases, all methods can retrieve clear ballistic or first arrivals. However, they yield significant differences in preserving the phase and amplitude information. This study provides a practical guide for choosing the optimal stacking method for specific research applications in ambient noise seismology. We evaluate the performance using multiple onshore and offshore seismic arrays in the Pacific Northwest region. We compare these stacking methods for NCFs calculated from raw ambient noise (referred to as Raw NCFs) and from ambient noise normalized using a one-bit clipping time normalization method (referred to as One-bit NCFs). We evaluate six metrics, including signal-to-noise ratios, phase dispersion images, convergence rate, temporal changes in the ballistic and coda waves, relative amplitude decays with distance and computational time. We show that robust stacking is the best choice for all applications (velocity tomography, monitoring and attenuation studies) using Raw NCFs. For applications using One-bit NCFs, all methods but phase-weighted and Nth-root stacking are good choices for seismic velocity tomography. Linear, robust and selective stacking methods are all equally appropriate choices when using One-bit NCFs for monitoring applications. For applications relying on accurate relative amplitudes, the linear, robust, selective and cluster stacking methods all perform well with One-bit NCFs. The evaluations in this study can be generalized to a broad range of time-series analysis that utilizes data coherence to perform ensemble stacking. Another contribution of this study is the accompanying open-source software package, StackMaster, which can be used for general purposes of time-series stacking.
Aberrant Mucin Expression Profiles Associate With Pediatric Inflammatory Bowel Disease Presentation and Activity
Authors: Breugelmans Tom , Arras Wout , Boen Lauren-Emma , Borms Eliah , Kamperdijk Lisa , De Man Joris , Van de Vijver Els , Van Gils Ann , De Winter Benedicte Y , Moes Nicolette , Smet Annemieke
Published: October 2022

Background

Intestinal mucosal healing is nowadays preferred as the therapeutic endpoint in inflammatory bowel disease (IBD), but objective measurements at the molecular level are lacking. Because dysregulated mucin expression is suggested to be involved in mucosal barrier dysfunction in IBD, we investigated mucin expression in association with barrier mediators and clinical characteristics in colonic tissue of a pediatric IBD population.

Methods

In this cross-sectional monocentric study, we quantified messenger RNA (mRNA) expression of mucins, intercellular junctions, and cell polarity complexes in inflamed and noninflamed colonic biopsies from pediatric IBD (n = 29) and non-IBD (n = 15) patients. We then validated mucin expression at protein level and correlated mucin mRNA expression with expression of barrier mediators and clinical data.

Results

The expression of MUC1, MUC3A, MUC4, and MUC13 was increased in the inflamed colon of pediatric IBD patients compared with the noninflamed colon of non-IBD control subjects. Especially MUC13 mRNA expression associated with the expression of barrier mediators, including CDH1, OCLN, and TJP2. MUC1 and MUC3B mRNA expression in combination with calprotectin levels most accurately discriminated IBD patients from non-IBD control subjects (90.6% area under the receiver-operating characteristic curve [AUCROC], 92.0% sensitivity, 73.7% specificity), whereas aberrant mRNA expression of MUC1, MUC3A, MUC4, and MUC13 was distinctive for ulcerative colitis and of MUC3B for Crohn’s disease. Furthermore, expression of MUC3A, MUC3B, and MUC4 correlated with clinical disease activity (ie, Pediatric Ulcerative Colitis Activity Index and Pediatric Crohn’s Disease Activity Index), and of MUC1, MUC2, MUC4, and MUC13 with endoscopic colitis severity in ulcerative colitis patients.

Conclusions

Colonic mucin expression is disturbed in pediatric IBD patients and associates with disease activity and presentation, suggesting its use as molecular marker to aid in disease diagnosis and management.
Repair of coronary artery ostium with a ring-shaped bovine pericardial patch
Authors: Zhang Dong , Zhu Gui-Jun , Wei Xiang-Yang , Li Bin , Hu Jie , Ma Wei-Guo , Chen Xing-Peng
Published: October 2022

As an approach to coronary artery ostial injury in type A aortic dissection and infective endocarditis, we describe a technique of coronary ostial repair using a ring-shaped bovine pericardial patch. The inner and outer rims of the patch were sutured to the involved coronary ostium (to close the ostial tear) and to the aortic wall (to cover the sinus), respectively. Four patients were successfully managed and computed tomographic coronary arteriogram at follow-up showed patent coronary ostia and arteries. The favourable preliminary results imply that this technique is a simple, safe and effective approach to coronary ostial repair in patients with type A aortic dissection or infective endocarditis.
Staged single-port thoracoscopic R2 sympathicotomy as a reproducible, safe and effective treatment option for debilitating severe facial blushing
Authors: van der Weijde Emma , Kuijpers Michiel , Bouma Wobbe , Mariani Massimo A , Klinkenberg Theo J
Published: October 2022

OBJECTIVES

Our goal was to investigate the safety, feasibility, success rate, complication rate and side effects of staged single-port thoracoscopic R2 sympathicotomy in the treatment of severe facial blushing. Facial blushing is considered a benign condition; however, severe facial blushing can have a major impact on quality of life. When nonsurgical options such as medication and psychological treatments offer no or insufficient relief, surgical treatment with thoracoscopic sympathicotomy should be considered.

METHODS

All patients who underwent a staged thoracoscopic sympathicotomy at level R2 for severe facial blushing between January 2016 and September 2021 were included. Clinical and surgical data were prospectively collected and analysed.

RESULTS

A total of 16 patients with low operative risk (American Society of Anesthesiologists class 1) were treated. No major perioperative complications were encountered. One patient experienced postoperative unilateral Horner’s syndrome that resolved completely after 1 week. Two patients experienced compensatory hyperhidrosis. The success rate was 100%. One patient experienced a slight recurrence of blushing symptoms after 3 years that did not interfere with their quality of life. All patients were satisfied with the results and had no regrets of having undergone the procedure.

CONCLUSIONS

Staged single-port thoracoscopic R2 sympathicotomy is a reproducible, safe and highly effective surgical treatment option with low compensatory hyperhidrosis rates and the potential to significantly improve quality of life in carefully selected patients suffering from severe facial blushing. We would like to increase awareness among healthcare professionals for debilitating facial blushing and suggest timely referral for surgical treatment.
In Search of Gaps between Languages and Wordnets: the Case of Polish-English WordNet
Authors: Rudnicka Ewa , Grabowski Łukasz , Piasecki Maciej , Naskręt Tomasz
Published: October 2022

The results of manual mapping of Polish plWordNet onto English Princeton WordNet revealed a number of gaps and mismatches between those interlinked lexical resources. Preliminary studies have shown that they embrace wordnet-specific and language-specific differences, and in this exploratory study we focus on the latter, also called lacunae. Capitalising on the system of equivalence types and features for linking wordnet senses (Rudnicka et al. 2019), we present a semi-automatic, rule-based diagnostic system developed specifically for systematic detection and classification of gaps and mismatches between wordnets. First, focusing on noun synsets, we aim to identify those network fragments that are the most prone to reveal lexical and referential gaps (Svensén 2009). Second, we attempt to identify areas in an interlinked Polish-English wordnet that require resource expansion or modification of the existing network of inter-lingual relations.
A Genealogical Study of Kuang Qizhao’s An English and Chinese Lexicon (1868)
Authors: Li Rui , Zhang Chun , Xu Hai
Published: October 2022

Embedded in historical and genealogical research, this study investigates the influence of English-Chinese dictionaries compiled by missionaries on Kuang Qizhao’s (1836?–1891?) An English and Chinese Lexicon, compiled in part from those of Morrison, Medhurst and Williams (1868). Drawing on Hartmann’s genealogical approach and the lexicographical findings and linguistic evidence presented in three case studies, we argue that Kuang depended not only on Walter Henry Medhurst’s (1796–1857) English and Chinese Dictionary (1847–48), Samuel Well Williams’ (1812–1884) An English and Chinese Vocabulary (1844) and Robert Morrison’s (1782–1834) English and Chinese dictionary (1822), as indicated in the dictionary title, but also on Wilhelm Lobscheid’s (1822-1893) An English and Chinese Dictionary (1866–69) for his own dictionary. And yet Kuang never acknowledged Lobscheid’s dictionary as one of his source dictionaries. This article discusses the reasons why Kuang failed to acknowledge the importance of Lobscheid’s contribution to his dictionary. It is expected to that the findings we have made will provide insights into the genealogical study of English-Chinese dictionaries in general, as well as confirming Kuang’s remarkable merit in compiling his English-Chinese dictionary in the 19th century.
Temporal Labels and Specifications in Monolingual English Dictionaries
Authors: Norri Juhani
Published: October 2022

The article examines the temporal labels and other specifications of time affixed to twenty-five words in monolingual dictionaries of English. The selection of works studied includes learners’, collegiate, and general-purpose dictionaries, both British and American. In addition, the treatment of the lexemes in the Oxford English Dictionary is noted. The analysis reveals some clear differences between the different types of dictionaries in the overall propensity to furnish temporal labels and other specifications of time. The terminology employed to convey such information varies from one group of dictionaries to another. There is also plenty of variation between the individual volumes inside each group. The target audience of the works examined varies, which explains some of the differences in the treatment of particular lexemes. In general, Osselton’s calls for more consistent terminology in the labelling of old words, presented several decades ago, are still valid. The differences between the labels are not always clear, and the explanations in the front matter of the dictionary may be lacking or unhelpful.
Optimal analyticity estimates for non-linear active–dissipative evolution equations
Authors: Papageorgiou Demetrios T , Smyrlis Yiorgos-Sokratis , Tomlin Ruben J
Published: October 2022

Active–dissipative evolution equations emerge in a variety of physical and technological applications including liquid film flows, flame propagation, epitaxial film growth in materials manufacturing, to mention a few. They are characterized by three main ingredients: a term producing growth (active), a term providing damping at short length scales (dissipative) and a nonlinear term that transfers energy between modes and crucially produces a nonlinear saturation. The manifestation of these three mechanisms can produce large-time spatiotemporal chaos as evidenced by the Kuramoto-Sivashinsky equation (negative diffusion, fourth-order dissipation and a Burgers nonlinearity), which is arguably the simplest partial differential equation to produce chaos. The exact form of the terms (and in particular their Fourier symbol) determines the type of attractors that the equations possess. The present study considers the spatial analyticity of solutions under the assumption that the equations possess a global attractor. In particular, we investigate the spatial analyticity of solutions of a class of one-dimensional evolutionary pseudo-differential equations with Burgers nonlinearity, which are periodic in space, thus generalizing the Kuramoto-Sivashinsky equation motivated by both applications and their fundamental mathematical properties. Analyticity is examined by utilizing a criterion involving the rate of growth of suitable norms of the $n$th spatial derivative of the solution, with respect to the spatial variable, as $n$ tends to infinity. An estimate of the rate of growth of the $n$th spatial derivative is obtained by fine-tuning the spectral method, developed elsewhere. We prove that the solutions are analytic if $\gamma $, the order of dissipation of the pseudo-differential operator, is higher than one. We also present numerical evidence suggesting that this is optimal, i.e. if $\gamma $ is not larger that one, then the solution is not in general analytic. Extensive numerical experiments are undertaken to confirm the analysis and also to compute the band of analyticity of solutions for a wide range of active–dissipative terms and large spatial periods that support chaotic solutions. These ideas can be applied to a wide class of active–dissipative–dispersive pseudo-differential equations.
Clinically undetected polyclonal heteroresistance among Pseudomonas aeruginosa isolated from cystic fibrosis respiratory specimens
Authors: Maxwell Daniel N , Kim Jiwoong , Pybus Christine A , White Leona , Medford Richard J , Filkins Laura M , Monogue Marguerite L , Rae Meredith M , Desai Dhara , Clark Andrew E , Zhan Xiaowei , Greenberg David E
Published: October 2022

Background

Pseudomonas aeruginosa infection is the leading cause of death among patients with cystic fibrosis (CF) and a common cause of difficult-to-treat hospital-acquired infections. P. aeruginosa uses several mechanisms to resist different antibiotic classes and an individual CF patient can harbour multiple resistance phenotypes.

Objectives

To determine the rates and distribution of polyclonal heteroresistance (PHR) in P. aeruginosa by random, prospective evaluation of respiratory cultures from CF patients at a large referral centre over a 1 year period.

Methods

We obtained 28 unique sputum samples from 19 CF patients and took multiple isolates from each, even when morphologically similar, yielding 280 unique isolates. We performed antimicrobial susceptibility testing (AST) on all isolates and calculated PHR on the basis of variability in AST in a given sample. We then performed whole-genome sequencing on 134 isolates and used a machine-learning association model to interrogate phenotypic PHR from genomic data.

Results

PHR was identified in most sampled patients (n = 15/19; 79%). Importantly, resistant phenotypes were not detected by routine AST in 26% of patients (n = 5/19). The machine-learning model, using the extended sampling, identified at least one genetic variant associated with phenotypic resistance in 94.3% of isolates (n = 1392/1476).

Conclusion

PHR is common among P. aeruginosa in the CF lung. While traditional microbiological methods often fail to detect resistant subpopulations, extended sampling of isolates and conventional AST identified PHR in most patients. A machine-learning tool successfully identified at least one resistance variant in almost all resistant isolates by leveraging this extended sampling and conventional AST.
Eosinophilic mastitis: a rare benign inflammatory condition and review of the literature
Authors: Arnott William , Leong Gregory , Davis Arie , Diab Jason , Clement Zackariah
Published: October 2022

We report the case of a 53-year-old nulliparous female presenting with a 9-month history of recurrent mastitis and a retro-areolar lesion. Histological assessment showed an inflammatory infiltrate predominantly composed of eosinophils without evidence of malignant changes. The patient was diagnosed with eosinophilic mastitis and commenced on a course of oral steroids with good effect. This case will outline the pathology, clinical manifestations and diagnosis of eosinophilic mastitis alongside a review of the literature.
Resection of an intrapulmonary solitary fibrous tumor in the center of the middle lobe: a case report
Authors: Hirai Yoshimitsu , Iwahashi Yoshifumi , Kogure Miwako , Shima Aya , Nakamura Rie , Hirai Issei
Published: October 2022

A 75-year-old female patient was referred to our hospital due to an abnormal shadow detected by chest X-ray. Computed tomography scans revealed a well-circumscribed nodule measuring 28 mm between B4 and B5 in the right middle lobe. Because the tumor was in the center of right middle lobe, a middle lobe resection was performed. The tumor was located within the lung and there were no obvious pleural surface changes. Postoperative histological findings showed 34-mm firm and round tumor, and well circumscribed without involving the visceral pleura. The pathologic examination revealed proliferating spindle-shaped cells with a random fascicular arrangement with continuity to the pulmonary interstitium. Not much cellular atypia was observed. Immunohistochemical staining indicated that the tumor was positive for STAT6, CD34. The final diagnosis was an intrapulmonary benign solitary fibrous tumor (SFT). Even benign intrapulmonary SFTs that have been completely resected may later become malignant and recur, and careful follow-up is necessary.
Translator attribution for Arabic using machine learning
Authors: Mohamed Emad , Sarwar Raheem , Mostafa Sayed
Published: October 2022

Given a set of target language documents and their translators, the translator attribution task aims at identifying which translator translated which documents. The attribution and the identification of the translator’s style could contribute to fields including translation studies, digital humanities, and forensic linguistics. To conduct this investigation, firstly, we develop a new corpus containing the translations of world-famous books into Arabic. We then pre-process the books in our corpus which mainly involves cleaning irrelevant material, morphological segmentation analysis of words, and devocalization. After pre-processing the books, we propose to use 100 most frequent words and/or morphologically segmented function words as writing style markers of the translators (i.e. stylometric features) to differentiate between translations of different translators. After the completion of features extraction process, we applied several supervised and unsupervised machine-learning algorithms along with our novel cluster-to-author index to perform this task. We found that the translators are not invisible, and morphological analysis may not be more useful than just using the 100 most frequent words as features. The support vector machine linear kernel algorithm reported 99% classification accuracy. Similar findings were reported by the unsupervised machine-learning methods, namely, K-mean clustering and hierarchical clustering.
Should states restrict recipient choice amongst relevant and available COVID-19 vaccines?
Authors: Cave Emma , McMahon Aisling
Published: October 2022

Several COVID-19 vaccinations have been authorised worldwide. Whilst some vaccines are contraindicated for certain age groups or health conditions, there are often multiple clinically suitable authorised vaccine brands available. Few states have allowed recipients to choose amongst them, though there are multiple reasons why choice would be valued. We consider the policy justifications for state controls on recipient choice amongst COVID-19 vaccine brands, focusing on European countries and drawing on the UK context as an example. We contrast justifications for not offering choice at the height of the early pandemic crisis, and as some states seek to de-escalate their response and transition towards living with COVID-19. We argue that in the latter context public expectations of choice between available vaccine brands and platforms may rise, but that several considerations may justify continued restrictions on choice. A key factor which states should continue to take into consideration is the global nature of the pandemic. Insofar as offering recipient choice at a national level might exacerbate global inequity in vaccine distribution, states retain a normative and legal justification for restricting choice amongst available and clinically suitable vaccine brands.
Intermediate redshift calibration of gamma-ray bursts and cosmic constraints in non-flat cosmology
Authors: Luongo Orlando , Muccino Marco
Published: October 2022

We propose a new method to calibrate gamma-ray burst (GRB) correlations employing intermediate redshift data sets, instead of limiting to z ≃ 0 catalogues, and applied it to the well-consolidated Amati correlation. This model-independent calibration technique is based on the Bézier polynomial interpolation of the most updated observational Hubble data and baryonic acoustic oscillations (BAO) and alleviates de facto the well-known circularity problem affecting GRB correlations. In doing so, we also investigate the influence of the BAO scales rs, got from Planck results, and $r_{\rm s}^{\rm fid}$, got from the considered fiducial cosmology, by considering the cases $(r_{\rm s}/r_{\rm s}^{\rm fid})=1$ and $(r_{\rm s}/r_{\rm s}^{\rm fid})\ne 1$. We get constraints on the cosmic parameters, using Markov chain–Monte Carlo simulations, first fixing and then leaving free the spatial curvature density parameter Ωk. Compared to previous literature, we obtain tighter constraints on the mass density parameter Ωm. In particular, our findings turn out to be highly more compatible with those got from standard candle indicators within the Lambda cold dark matter paradigm. Finally, we critically re-examine the recent H0 tension in view of our outcomes.
Residual neural networks for the prediction of planetary collision outcomes
Authors: Winter Philip M , Burger Christoph , Lehner Sebastian , Kofler Johannes , Maindl Thomas I , Schäfer Christoph M
Published: October 2022

Fast and accurate treatment of collisions in the context of modern N-body planet formation simulations remains a challenging task due to inherently complex collision processes. We aim to tackle this problem with machine learning (ML), in particular via residual neural networks. Our model is motivated by the underlying physical processes of the data-generating process and allows for flexible prediction of post-collision states. We demonstrate that our model outperforms commonly used collision handling methods such as perfect inelastic merging and feed-forward neural networks in both prediction accuracy and out-of-distribution generalization. Our model outperforms the current state of the art in 20/24 experiments. We provide a data set that consists of 10164 Smooth Particle Hydrodynamics (SPH) simulations of pairwise planetary collisions. The data set is specifically suited for ML research to improve computational aspects for collision treatment and for studying planetary collisions in general. We formulate the ML task as a multi-task regression problem, allowing simple, yet efficient training of ML models for collision treatment in an end-to-end manner. Our models can be easily integrated into existing N-body frameworks and can be used within our chosen parameter space of initial conditions, i.e. where similar-sized collisions during late-stage terrestrial planet formation typically occur.
USP36 promotes tumorigenesis and drug sensitivity of glioblastoma by deubiquitinating and stabilizing ALKBH5
Authors: Chang Guoqiang , Xie Gloria S , Ma Li , Li Linlin , Richard Hope T
Published: October 2022

Background

ALKBH5 is aberrantly activated and exerts critical roles in facilitating the development of glioblastoma. However, the underlying activation mechanism by which ALKBH5 protein is increased in glioblastoma is not completely understood. Our study aimed to elucidate the signaling pathways involved in mediating ALKBH5 protein stability.

Methods

The contribution of deubiquitinating enzymes (DUB) to the fluctuation of ALKBH5 protein expression was globally profiled with western blot analysis. Mass spectrometry and immunoprecipitation were performed to identify the USP36 and ALKBH5 interaction. The effects of USP36 on the stability of ALKBH5 were detected with in vivo and in vitro ubiquitination assays. Cell proliferation assays, neurosphere formation, limited dilution assay, and intracranial tumor growth assays were implemented to assess the collaborative capacities of USP36 and ALKBH5 in tumorigenesis.

Results

Ubiquitin-specific peptidase 36 (USP36), as a potential ALKBH5-activating DUB, played an essential role in stabilization of ALKBH5 and regulation of ALKBH5-mediated gene expression in glioblastoma. The depletion of USP36 drastically impaired cell proliferation deteriorated the self-renewal of GSCs and sensitized GSCs to temozolomide (TMZ) treatment. Furthermore, the deletion of USP36 substantially decreased the in vivo tumor growth when monitored by bioluminescence imaging. Our findings indicate that USP36 regulates the protein degradation and expression of ALKBH5, and the USP36-ALKBH5 axis orchestrates glioma tumorigenesis.

Conclusion

Our findings identify USP36 as a DUB of ALKBH5 and its role in glioblastoma progression, which may serve as a potential therapeutic target for glioblastoma treatment.
Multi-legged robots: progress and challenges
Authors: Gao Yue , Su Bo , Jiang Lei , Gao Feng
Published: October 2022

Multi-legged robots have achieved great advancements and gained attention from academia and industry. Opportunities are rising for their potential applications in human society and dangerous environments.
Development of a Clinical Prediction Score Including Monocyte-to-Lymphocyte Ratio to Inform Tuberculosis Treatment Among Children With HIV: A Multicountry Study
Authors: Malik Amyn A , Gandhi Neel R , Marcy Olivier , Walters Elisabetta , Tejiokem Mathurin , Chau Giang Do , Omer Saad B , Lash Timothy L , Becerra Mercedes C , Njuguna Irene N , LaCourse Sylvia M , Maleche-Obimbo Elizabeth , Wamalwa Dalton , John-Stewart Grace C , Cranmer Lisa M
Published: October 2022

Background

Clinical pediatric tuberculosis (TB) diagnosis may lead to overdiagnosis particularly among children with human immunodeficiency virus (CHIV). We assessed the performance of monocyte-lymphocyte ratio (MLR) as a diagnostic biomarker and constructed a clinical prediction score to improve specificity of TB diagnosis in CHIV with limited access to microbiologic testing.

Methods

We pooled data from cohorts of children aged ≤13 years from Vietnam, Cameroon, and South Africa to validate the use of MLR ≥0.378, previously found as a TB diagnostic marker among CHIV. Using multivariable logistic regression, we created an internally validated prediction score for diagnosis of TB disease in CHIV.

Results

The combined cohort had 601 children (median age, 1.9 [interquartile range, 0.9–5.3] years); 300 (50%) children were male, and 283 (47%) had HIV. Elevated MLR ≥0.378 had sensitivity of 36% (95% confidence interval [CI], 23%–51%) and specificity of 79% (95% CI, 71%–86%) among CHIV in the validation cohort. A model using MLR ≥0.28, age ≥4 years, tuberculin skin testing ≥5 mm, TB contact history, fever >2 weeks, and chest radiograph suggestive of TB predicted active TB disease in CHIV with an area under the receiver operating characteristic curve of 0.85. A prediction score of ≥5 points had a sensitivity of 94% and specificity of 48% to identify confirmed TB, and a sensitivity of 82% and specificity of 48% to identify confirmed and unconfirmed TB groups combined.

Conclusions

Our score has comparable sensitivity and specificity to algorithms including microbiological testing and should enable clinicians to rapidly initiate TB treatment among CHIV when microbiological testing is unavailable.