bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Yoga Therapy on Hypothyroidism: A Systematic Review
Authors: Bhandari Rudra B. , Mahto Pintu K.
Published: October 2024

Background

Hypothyroidism (HT) is the most prevalent endocrine disorder, affecting approximately one in 10 out of 35 adults, with a higher prevalence in females and the elderly.

Purpose

This systematic review (SR) aimed to discuss the effects of yoga on markers and comorbid conditions of HT.

Methods

The SR was registered with the PROSPERO (PROSPERO 2022 CRD42022312990). Google Scholar, PubMed, Cochrane, and EMBASE were searched for the relevant English language interventional studies published from 31 December 1947 to 31 December 2023 by using the keywords ‘meditation OR breath regulation OR yoga OR yoga nidra AND hypothyroidism OR hypothyreosis OR underactive thyroid OR low thyroid’. Of the 4078 screened studies, eight eligible studies (three RCTs, two pilot studies, two pre-post trials, and one case study) with 421 HT patients (392 females and 29 males) and three to six-month yoga interventions were included. Two independent review authors extracted study characteristics and synthesised them descriptively. RCTs and NRSIs were assessed for risk-of-bias (RoB) using Cochrane tools RoB2 and ROBINS-1.

Results

The findings suggest that yoga effectively improves the thyroid profile, lipid profile, heart rate variability, pulmonary functions, anxiety, depression, and quality of life among HT patients.

Conclusion

Yoga may be an inexpensive add-on preventive and therapeutic option for HT. The clinical and methodological heterogeneity among the studies did not allow for meta-analysis (MA). Well-designed MAs are warranted by including rigorous RCTs to draw valid conclusions and defined mechanisms regarding the efficacy of yoga practices/interventions on HT.
Preoperative abaloparatide plus zoledronate treatment accelerates femoral bone healing in rats following osteotomy
Authors: Kataoka Takashi , Tsubouchi Yuta , Takase Ryota , Otsu Takefumi , Iwasaki Tatsuya , Kataoka Masashi , Kaku Nobuhiro
Published: October 2024

Purpose: We investigated the potential efficacy of abaloparatide (Abalo) and zoledronate (ZA) combination therapy for accelerating femoral union in a rat osteotomy model. Methods: Nine-week-old male Sprague–Dawley rats were randomly divided into four groups ( n = 14 per group): control, abaloparatide (Abalo, 30 μg/kg via subcutaneous injection [s.c.] 5 times per week for 6 weeks), zoledronate (ZA; 0.1 mg/kg via s.c., single dose), and Abalo + ZA. Rats were then subjected to unilateral osteotomy of the femoral shaft, followed by osteosynthesis with intramedullary nailing to establish bone healing models. At 2 and 4 weeks after osteotomy, both femurs were removed from seven rats per group for soft X-ray imaging to evaluate bone union and microcomputed tomography (micro-CT) for bone morphometric evaluation. Blood samples were collected from all rats every 2 week starting 6 weeks pre- to 4 weeks postosteotomy. Toluidine blue staining was used for histopathological evaluation of the undecalcified specimens. Results: Soft X-ray imaging revealed accelerated callus formation, callus maturation, and fracture line closure in Abalo and Abalo + ZA groups compared to ZA and control groups. Micro-CT demonstrated greater cortical bone and trabecular bone to total volume ratios in contralateral (left) femurs of the Abalo + ZA group compared to the Abalo group. Both trabecular and cortical bone mineral densities were also greater in contralateral femurs of the Abalo + ZA group compared to Abalo and ZA groups. Conclusion: These findings suggest substantial additive or synergistic efficacy of abaloparatide plus zoledronate combination therapy for accelerating bone healing following osteotomy and for maintaining normal bone health.
The contribution of digitalization to non-inclusive growth in Japan. A Régulationist perspective on post-industrial dynamics
Authors: Lechevalier Sébastien , Shibata Saori
Published: October 2024

While inclusive growth has been considered a major characteristic of post-war Japan, this is no more the case since the early 1990s as the country transitioned to a post-industrial economy. This paper seeks to explain that digitalization is a primary drive of growing inequalities in post-industrial Japan and argues for incorporating the digital divide into the investigation of changing economic structures and growth patterns. We mobilize the Régulation theoretical framework, which posits that the impact of technology on growth and inequality regimes is not homogenous across countries and over time. Our empirical investigation combines macro-level data and institutional perspective with case study of the hospitality sector, in line with the Régulationist concept of the ‘anthropogenic’ mode of development. Our major conclusion is that digitalization, in the specific Japanese context, is leading to non-inclusive growth patterns through its effects on the wage-labour nexus, in an idiosyncratic way.
Addressing Worker Safety and Health Through the Lens of Strategic Enforcement—Part 2
Authors: Felsen Michael
Published: October 2024

Ensuring the safety and health of workers in this country, who are employed at millions of workplaces presenting a dizzying array of hazards, is beyond daunting. And yet, it is exceptionally important, because the lives and well-being of countless workers, and their families, hang in the balance. Every day, workers are maimed or die of their workplace injuries or occupational illnesses. These outcomes are unacceptable. Agencies must use all the means at their disposal to keep workers safe and healthy in their workplaces. This paper addresses this challenge through the lens of strategic enforcement, with the goal of maximizing enforcement effectiveness to save lives and limbs.

First, we examine how, under the Occupational Safety and Health Act, federal and state enforcement schemes are designed to interact. Next, we dive into the impressive array of strategic enforcement tools that are available to federal, state, and local enforcers, and we observe that many of them are either unrecognized or underutilized. We emphasize that these are all significant, because, given our limited enforcement resources, we need to use every tool we can muster—from strategic targeting, to enterprise-wide enforcement, to heightening deterrence through more robust penalty assessments and publicity, to valuing and making the most of partnerships and coenforcement efforts with a wide range of organizations and agencies. And we need to engage in a process of continual evaluation and improvement of our tools and assets, always striving to maximize our enforcement leverage in aid of worker safety and health. Finally, we examine an impressive list of initiatives state and local governments have taken, beyond what the OSH Act mandates, in their efforts to go the extra mile for the safety of the workers in their states and cities. These examples are intended to inspire federal, state and local agencies to do the same, or, hopefully, even better. The stakes are high. Workers deserve to work in safe and healthy environments. This paper is intended to provide practical ways in which state and local agencies can better—and potentially far better—satisfy that obligation.
Insights From Community Organizations Collaborating With Government and Academia to Foster Health Literacy
Authors: Ojeda Victoria D. , Vicente Sarah , Sheik-Mohamed Amina , Zubaidi Reem , Bearse Adriana , Nash Valerie , Kurz Stacey , Marquez Denise , Barrios Anthony , Crespo Noe C. , Melendrez Blanca
Published: October 2024

Introduction

The COVID-19 pandemic disproportionately impacted ethnic minority and other underserved communities, prompting the federal government to fund community-led health literacy initiatives. This evaluation shares challenges and lessons learned, and identifies best practices from community-based organizations (CBOs) partnering with academia and local government to support health literacy programming.

Methods

In 2023, 20 representatives from 12 CBOs in Southern California responded to an interviewer-administered survey, including open-ended questions about lessons learned. We analyze text data to identify key themes.

Results

CBOs expressed a need for additional financial resources and technical assistance, including grantsmanship training, access to in-language resources, support to build and use in-house evaluation systems, and greater university oversight for student collaborators. Respondents highlighted the importance of community engagement efforts to build trust and enhance the uptake of programming. They also stressed the need for specialized training of community health workers engaged in health programs and the utilization of population sub-group data to inform policy and funding development to better serve communities’ needs.

Conclusion

CBOs are eager to partner with government and academia and acknowledge the need for targeted support and resources that can be facilitated through multisectoral partnerships. We offer recommendations and actionable strategies for funders and academia to create and improve equitable partnerships with CBOs. Partnerships that address the needs and systemic barriers experienced by ethnic minority communities will support local public health goals while fostering resilience and health equity.
Chaxu Climate as a Double-Edged Sword: A Moderated Mediation Model of Organizational Justice, Hierarchy Level on Turnover Intention
Authors: Zheng Yuheng , Gao Yixing (Lisa) , Feng Tao
Published: October 2024

Research on chaxu climate, a prevalent organizational phenomenon in China, has captured significant academic attention in recent years. This study aims to explain why some employees who experience chaxu climate in hospitality organizations contemplate leaving, while others do not. We propose a moderated mediation model to examine the double-edged sword impact of chaxu climate on turnover intention. Through one qualitative study and two scenarios-based experimental studies, we reveal that organizational justice plays a crucial role as a contextual cue, influencing employees’ attribution of chaxu climate and subsequent turnover intention. Perceived insider status is identified as a mediator. Furthermore, we establish a second-level moderating effect of the hierarchy level, distinguishing between supervisor and front-line employees. Theoretical and practical implications are discussed accordingly.
Complete retinal pigment epithelium and outer retinal atrophy: Is it really an end-stage atrophy?
Authors: Santamaría Juan , Pagani Fernando , Monés Jordi
Published: October 2024

Geographic atrophy (GA), a late manifestation of age-related macular degeneration (AMD), leads to irreversible vision loss. Early identification of precursor lesions, such as incomplete and complete retinal pigment epithelium and outer retinal atrophy (iRORA and cRORA), is crucial for predicting GA formation. The latter stage has been associated with irreversible and progressive changes, and the eventual development of a dense scotoma on the compromised area. We present an 80-year-old woman with AMD in both eyes, demonstrating progressive changes over a 2-year follow-up. While the right eye developed cRORA with vision decline, the left eye exhibited unexpected restoration of the outer retinal layers within the cRORA lesion. This finding challenges the notion of “end-stage atrophy” in GA development and highlights the potential reversibility of early atrophic lesions. Recognizing these dynamics has implications for the development of targeted therapies aimed at preserving vision in AMD's early stages.
Commitment Complex Splicing Factors in Cancers of the Gastrointestinal Tract—An In Silico Study
Authors: Zhang Yun , Simko Alexandria Carrasquillo , Okoro Uzondu , Sibert Deja Jamese , Moon Jin Hyung , Liu Bin , Matin Angabin
Published: October 2024

The initial step in pre-mRNA splicing involves formation of a spliceosome commitment complex (CC) or E-complex by factors that serve to bind and mark the exon-intron boundaries that will undergo splicing. The CC component U1 snRNP assembles at the 5′-splice site (ss), whereas SF1, U2AF2, and U2AF1 define the 3′-ss of the intron. A PRP40 protein bridges U1 snRNP with factors at the 3′-ss. To determine how defects in CC components impact cancers, we analyzed human gastrointestinal (GI) cancer patient tissue and clinical data from cBioPortal. cBioPortal datasets were analyzed for CC factor alterations and patient outcomes in GI cancers (bowel, stomach, esophagus, pancreas, and liver). In addition, co-expression datasets were used to determine the splicing targets of the CC. Our analysis found that frequency of genetic changes was low (1%-13%), but when combined with changes in expression levels, there was an overall surprisingly high incidence of CC component (>30%) alterations in GI cancers. Colon cancer patients carrying BRAF driver gene mutations had high incidences of CC alterations (19%-61%), whereas patients with APC, KRAS, or TP53 gene mutations had low (<5%) incidences of CC alterations. Most significantly, patients with mutations in CC genes exhibited a consistent trend of favorable survival rates, indicating that mutations that impair or lower CC component expression favor patient survival. Conversely, patients with high CC expression had worse survival. Pathway analysis indicates that the CC regulates specific metabolic and tumor suppressor pathways. Metabolic pathways involved in cell survival, nutrition, biosynthesis, autophagy, cellular movement (invasion), or immune surveillance pathways correlated with CC factor upregulation, whereas tumor suppressor pathways, which regulate cell proliferation and apoptosis, were inversely correlated with CC factor upregulation. This study demonstrates the versatility of in silico analysis to determine molecular function of large macromolecular complexes such as the spliceosome CC. Furthermore, our analysis indicates that therapeutic lowering of CC levels in colon cancer patients may enhance patient survival.
The Impact of Tobacco Smoking on Systemic Sclerosis, Idiopathic Inflammatory Myositis, and Systemic Lupus Erythematosus
Authors: El Hasbani Georges , Madi Mikel , Zoghbi Mohamad Al Sadek El , Srour Lara , Uthman Imad , Jawad Ali SM
Published: October 2024

This narrative review aims specifically to explore the relationship between tobacco exposure and systemic sclerosis (SSc), idiopathic inflammatory myositis (IIM), and systemic lupus erythematosus (SLE). Relevant articles were obtained by searching key terms such as “tobacco,” “smoking,” “scleroderma,” “myositis,” “lupus,” and “Sjögren’s” in PubMed and Google Scholar databases. The selected articles ranged from the years 2010 to 2023. Inclusion criteria were based on the relevance and contribution to the field of study. Systemic sclerosis is a complex condition involving multiple immune cell lines that can be influenced by tobacco. However, the existing literature does not provide sufficient evidence to support an increased risk of SSc in smokers or the impact on treatment options. Cigarette smoking does increase the risk of skin ulcerations in SSc patients. In addition, cigarette smoking has been associated with IIM through genetic and molecular mechanisms. Smokers with dermatomyositis or polymyositis are at an elevated risk of atherosclerosis and interstitial lung disease. Similarly, smoking in patients with SLE increases the risk of organ damage, thrombosis, and disease severity compared with non-smokers. Smokers with SLE also have more difficulty in controlling disease flares compared with non-smokers. Tobacco exposure can lead to secondary complications in patients with IIM and SLE, although the course of treatment may not differ significantly. No definitive conclusions can be drawn to the clear relationship between tobacco smoking and Sjögren’s’s syndrome.
Development and maturation of school principals’ viewpoint of physical education's value to the academic mission
Authors: Kern Ben D. , Palmer Laura
Published: October 2024

School principals are responsible for leadership toward meeting an academic mission predicated on student achievement in core subjects. Socialization experiences of principals relative to physical education (PE) may impact their perception of PE's academic value. Our purpose was to investigate the development and maturation of school principals’ perspective of the value of PE to their school’s academic mission. Eleven principals completed two in-depth interviews about their perception of PE's value to their school's academic mission. Interviews occurred prior to and following their PE teacher participating in extended professional development. Principals observed and assessed the teaching performance of their current PE teacher on two separate occasions between interviews. Occupational Socialization Theory guided inquiry and analysis. Principals’ positive and negative experiences during K-12 influenced their beliefs about the value of PE to the academic mission and were evident in performance expectations of their respective PE teacher. Professional training had little effect, but instructional leadership interactions with their PE teacher impacted principals’ beliefs about PE's value to the school’s academic mission. Positive changes in principal perceptions about the academic nature of PE were noted over the course of the study. Principal preparation programs offer little guidance in supporting PE. Opportunities to observe and reflect upon best practices with PE teachers may positively alter their beliefs. More guidance on evaluating teachers of specific content areas such as PE is warranted, and PE teachers may offset marginalization by engaging their principal about best practices that align with and support the school’s academic mission.
Overcoming embarrassment in humorous narratives among Pakistani young men: A case study
Authors: Azher Musarrat
Published: October 2024

This case study illustrates the use of humor support strategies by Pakistani young men in their conversation to overcome embarrassment and construct and maintain a humorous discursive frame. The present research draws on video recordings of Pakistani university young men’s conversation, analyzed using Hay’s framework of humor support strategies in relation to the pragmatic implicatures of full support. The findings reveal that laughter, overlaps, contributing more humor, repetition and contradicting self-deprecation are among the most prominent humor support strategies. These strategies not only indicate heightened involvement in the conversation but also serve to release the tension of being embarrassed. The study concludes that humor support is a coping strategy used by Pakistani young men for the release of the pressure of being in an awkward position and to open up space for the construction of humorous discourse.
Social work practice in complex emergencies: A study of Northwest Syria
Authors: Paul Karen , Denov Myriam , Al Houssami Lana
Published: October 2024

Existing scholarship discusses social work during war and conflict, but less social work scholarship specifically names and focuses on the reality of complex emergencies. This article discusses perspectives on “good” social work practice in complex emergencies by drawing upon a study of Northwest Syria which included 29 interviews with international and Syrian practitioners.

Findings

This study found that although Syria did not have a formal social work profession before the emergency, the crisis created a need for social work practice to bolster and help reactivate Syrian families and communities’ supportive nature. Participants perceived “good” social work practices as a range of practices, that are suitable to the community, which helped to reactivate the family and community's supportive role. Practitioners described how “good” social work practices incorporated Syrian culture and were best performed by practitioners with certain characteristics. Ultimately, this article argues social work practice should aim to reactivate rather than replace these important and existing culturally embedded forms of support.

Applications

During complex emergencies, “good” social work practice considers and incorporates cultural aspects such as spirituality and stigma. A range of social work practices, which are suitable to the community, can help to restore family and community supports. Practitioners who know the community, are trustworthy, and have a relevant background can best perform what are regarded as “good” social work practices.
Magnetic Resonance Imaging of Mammalian Cells Individually Expressing Membrane-Associated Magnetosome Proteins I, L, B, and E
Authors: Sun Qin , Varela-Mattatall Gabriel , Vivekanantha Prushoth , Ahmed Moeiz , Hassan Salvan , Hong Selinia , Gelman Neil , Thompson R. Terry , Prato Frank S. , Goldhawk Donna E.
Published: October 2024

The magnetosome, a membrane-bound iron biomineral formed within magnetotactic bacteria, is a unique model for a magnetic resonance imaging (MRI) reporter gene contrast agent. We are translating this technology to mammalian cells by expressing essential magnetosome genes mamI, mamL, mamB, and mamE into MDA-MB-435 human melanoma cells. Currently, these genes are individually expressed in the cell although the future goal is to express all four genes together. We examined the influence of these genes on cellular MRI relaxation rates by culturing cells in the presence and absence of iron-supplemented medium and scanning them at 3 Tesla using a gelatin phantom. Total cellular iron was measured by inductively-coupled plasma mass spectrometry and correlated with relaxation rates obtained from phantom experiments. Apart from mamE, magnetosome genes that are individually expressed in mammalian cells grown in iron supplement significantly affected cellular transverse relaxation rates compared to cells grown without iron supplement. Interestingly, mamI, mamL, mamB, and mamE (even though the latter had no effect on relaxation rate) significantly affected cellular iron content. This developing gene-based contrast agent will equip MRI with improvement to imaging sensitivity and the technology to track cellular activities long term.
Sharper Minds: Cognitive Recovery After Epilepsy Surgery in Children
Authors: Englot Dario J.
Published: October 2024

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Testing the Feasibility of a Newly Developed Lifestyle Practice Targeting Social Connections: Narrative Healing Circle Shared Medical Appointments
Authors: Loy Michelle H. , Audet Anne-Marie
Published: October 2024

The aim of this pilot was to assess the feasibility and acceptability of virtual Narrative Healing Circles (NHC), a new form of Shared Medical Appointments (SMA) among mixed diagnosis population within an urban tertiary academic medical center. Methods: Multi-method, voluntary recruitment of eligible patients, included referrals, flyers, hospital events page, and patients who participated in an ongoing 7-week integrative oncology SMA series. Two physicians (lifestyle medicine and chaplaincy specialists), both trained in narrative medicine, co-led one-hour long virtual NHC SMAs held every other week for a total of either 4 or 8 sessions. Sessions included a centering meditation, brief check-in, topic introduction, short writing exercise initiated with a written, musical, or visual prompt, followed by time of sharing and listening. Optional electronic pre and post participant surveys were emailed at enrollment (7-questions, response rate 29%) and after 4-8 NHC SMA sessions (12-questions, RR 34%). Results: Virtual NHC SMA were offered from 2/23/22-8/30/23 with 62 unique participants, 266 total visits. Average age: 57 years (range: 27-84 years). Gender: 85% Female, 15% Male; Ethnicity: 73% White, 16% African American, 6% Asian, 5 % Hispanic. About half lived in underserved areas (Harlem, Bronx, Queens, Brooklyn). Payor mix included 40% Medicare, 60% Commercial insurance. Session attendance: 6 participants (mean); 1-13 (range). The number of sessions attended ranged between 1-28 sessions. Anxiety or fear (89%), depression (61%) and pain (67%) were the top 3 symptoms reported in the pre-survey. After 4-8 sessions, participants reported improvements in anxiety/fear (43%), sadness/depression/hopelessness (33%), irritability/stress (33%), isolation/loneliness (33%). They reported several positive changes: restarting yoga or meditation practice, greater focus on awe, journaling, increased mindfulness, and feeling better equipped to manage stress. 94% reported goals met, 95% would recommend the series to others. The 2 clinician leaders reported increased empathy, personal well-being, and work satisfaction. Conclusion: Virtual NHC SMA series among mixed diagnosis population is feasible, positively affects patients’ agency and well-being, and acceptable to patients and providers. A more formal study design with broader representation of diverse population and assessment of causality such as an RCT with longer follow-up is recommended.
Are pragmatism and ethical protections in clinical trials a zero-sum game?
Authors: Nix Hayden P , Weijer Charles , Taljaard Monica
Published: October 2024

Background:

Randomized controlled trials with pragmatic intent aim to generate evidence that directly informs clinical decisions. Some have argued that the ethical protection of informed consent can be in tension with the goals of pragmatism. But the impact of other ethical protections on trial pragmatism has yet to be explored.

Purpose:

In this article, we analyze the relationship between additional ethical protections for vulnerable participants and the degree of pragmatism within the PRagmatic Explanatory Continuum Indicator Summary-2 (PRECIS-2) domains of trial design.

Methods:

We analyze three example trials with pragmatic intent that include vulnerable participants.

Conclusion:

The relationship between ethical protections and trial pragmatism is complex. In some cases, additional ethical protections for vulnerable participants can promote the pragmatism of some of the PRECIS-2 domains of trial design. When designing trials with pragmatic intent, researchers ought to look for opportunities wherein ethical protections enhance the degree of pragmatism.
Hope for leadership: Introduction to the special issue “leadership and the future of humanity”
Authors: Jaser Zahira , Tourish Dennis
Published: October 2024

This is an introduction to the Special Issue ‘Leadership and the Future of Humanity.’ We appraise the concept of leadership in the context of several major world crises, including the rise of populism, an increased number of conflicts, and the climate crisis. In observing the current conflicts in Russia/Ukraine and Israel/Palestine, we define hopeless leadership as the leadership of those who exploit despair and uncertainty to manufacture fear in order to move their followers into action against particular outgroups. We also look at how hope is often born from despair. In adopting Freire’s ontology of hope, we theorise hopeful leadership as the continuous belief in and search for possible and better futures, even if they are imperfect. In this sense, hopeful leadership has a strong element of stewardship towards the future of humanity. The Special Issue contains papers that tap into these themes, and develops them in their own way.
Mission reliability modeling based on extended RQR chain considering process scheme robustness for multistate manufacturing systems
Authors: Feng Tianyu , He Yihai , Li Jiayang , Shi Rui
Published: October 2024

Process scheme robustness is the core of the “Method” in 5M1E (Man, Machine, Material, Method, Measurement, and Environment), which is the foundation of manufacturing quality and reliability assurance. However, previous studies frequently overlooked the significant impact of the coupling between the process scheme and process parameter robustness on the formation and degradation of mission reliability. Therefore, a novel method for modeling mission reliability in a multistate manufacturing system is proposed. This method is based on an extended RQR chain (manufacturing system Reliability, operational process Quality, and the produced product Reliability) while considering process scheme robustness. First, the connotation of process scheme robustness and mission reliability in multistate manufacturing systems is described. Second, an extended RQR chain (ERQR chain) model is established, which considers the influence of process scheme robustness on the high-quality operation of the manufacturing system. Third, based on the established ERQR chain model, an integrated mission reliability model considering process scheme robustness for multistate manufacturing systems is established. Specifically, the process scheme robustness is evaluated from three perspectives: manufacturing cost, operation time, and product qualification rate. Finally, a hydraulic pump is used as an example to verify the effectiveness of the proposed approach.
Anti-Science Populism Versus Brazil's Covid-19 Vaccination Program: A Tale of Two Pandemic Stories
Authors: de Arruda Castro Gabriel , Reich Gary M.
Published: October 2024

Can civil servants protect the administrative state from illiberal populism? We argue that bureaucratic success in fending off illiberal populism necessitates both a supportive institutional environment and overcoming populist rhetoric meant to undermine public confidence in policy expertise. The Covid-19 pandemic in Brazil is a case study of populist antipathy toward a professional public health service. Brazil's public health officials were able to defy Jair Bolsonaro's obstruction of a Covid-19 mass vaccination program thanks to institutions characterised by insulation from executive reprisal, decentralised health care provision, and an independent judiciary. However, civil servant resistance was less effective in nullifying Bolsonaro's anti-vaccine rhetoric: Even as most Brazilians received Covid-19 vaccines, vaccination rates remained associated with electoral support for Bolsonaro and overall vaccine hesitancy increased. The Brazilian case suggests the power of populist rhetoric to undermine pluralist public administration by attacking its epistemic foundation, even in a context favorable to bureaucratic resistance.
A preliminary study on bamboo–timber composite columns under axial compression
Authors: Deng Yu , Xia Weidong , Yang Siqi , Ni Miao , Huo Gaxu , Zhang Hexin , Wong Simon HF , Sukontasukkul Piti , Hansapinyo Chayanon , Zhang Yuxin , Thepvongsa Khampaseuth , Seixas Mario , Filho João de Almeida Melo
Published: October 2024

Bamboo–timber composite columns hold significant promise as bio-based structural elements. However, research in this area remains limited, especially concerning modern buckling analysis methods that incorporate bio-based constitutive models of engineered bamboo and timber materials. This study aims to address this gap by proposing a proof-of-concept analytical framework based on component-based strategy for buckling analysis, utilising piecewise bio-based material constitutive models as the guide rail for its strain-stage-based component split-up. Preliminary experimental validation was performed to evaluate the feasibility of using component-based analysis to estimate the overall buckling resistance of both composite and non-composite bamboo and timber columns. This initial study offers an alternative analytical approach for estimating the buckling resistance of bio-composite columns and establishes a set of conceptual guidelines and indicative parameters for the experimental design of future research.
Hierarchical deep learning for autonomous multi-label arrhythmia detection and classification on real-world wearable electrocardiogram data
Authors: Zheng Guangyao , Lee Sunghan , Koh Jeonghwan , Pahwa Khushbu , Li Haoran , Xu Zicheng , Sun Haiming , Su Junda , Cho Sung Pil , Im Sung Il , Jeong In cheol , Braverman Vladimir
Published: October 2024

Objective

Arrhythmia detection and classification are challenging because of the imbalanced ratio of normal heartbeats to arrhythmia heartbeats and the complicated combinations of arrhythmia types. Arrhythmia classification on wearable electrocardiogram monitoring devices poses a further unique challenge: unlike clinically used electrocardiogram monitoring devices, the environments in which wearable devices are deployed are drastically different from the carefully controlled clinical environment, leading to significantly more noise, thus making arrhythmia classification more difficult.

Methods

We propose a novel hierarchical model based on CNN+BiLSTM with Attention to arrhythmia detection, consisting of a binary classification module between normal and arrhythmia heartbeats and a multi-label classification module for classifying arrhythmia events across combinations of beat and rhythm arrhythmia types. We evaluate our method on our proprietary dataset and compare it with various baselines, including CNN+BiGRU with Attention, ConViT, EfficientNet, and ResNet, as well as previous state-of-the-art frameworks.

Results

Our model outperforms existing baselines on the proprietary dataset, resulting in an average accuracy, F1-score, and AUC score of 95%, 0.838, 0.906 for binary classification, and 88%, 0.736, 0.875 for multi-label classification.

Conclusions

Our results validate the ability of our model to detect and classify real-world arrhythmia. Our framework could revolutionize arrhythmia diagnosis by reducing the burden on cardiologists, providing more personalized treatment, and achieving emergency intervention of patients by allowing real-time monitoring of arrhythmia occurrence.
The (Un)Predictability of Early (Un)Employment: A Machine Learning Approach
Authors: Kuikka Sanni
Published: October 2024

This article integrates scholarship on determinants of labor market transitions with the flexible modeling strategies available through machine learning. Leveraging population registers from Finland, this study analyzes how well we can predict (un)employment and for whom we can (not) predict. The study finds that the predictability of long-term (un)employment improves when using tree-based nonparametric models compared to logistic regression but that predictability varies substantially across outcome groups. None of the models predict very accurately for the unemployed net of baseline likelihood to be unemployed—a group that is well researched and often of interest when designing policies and interventions. Overall accuracy is driven by the employed while incorrectly predicting most of the unemployed. Additionally, the outcomes for individuals with low parental education are overall more difficult to predict than the outcomes for individuals with mid/high parental education, whereas predicting unemployment slightly improves among the low parental education group.
Child Incarceration and Maternal Alcohol Use: Disentangling Within- and Between-Person Processes
Authors: Greene Kaylin , Warner Cody
Published: October 2024

Having a child incarcerated can take a toll on the physical, psychological, and financial well-being of mothers. These factors could, in turn, affect behavioral outcomes of mothers, such as alcohol use patterns. Some mothers might drink to cope with the experience of having a child incarcerated, but others may reduce alcohol use for various reasons. Given these uncertainties, the authors examined the association between child incarceration and maternal alcohol consumption (i.e., any use, frequency, quantity, and binge drinking). Eight waves of nationally representative data from the National Longitudinal Survey of Youth 1979 cohort were linked with the National Longitudinal Survey Children and Young Adults ( n = 3,837 mothers; 678 had children incarcerated). Multilevel generalized linear regression models showed that compared with mothers with no child incarceration, mothers of ever-incarcerated children were more likely to binge drink and consume more drinks when drinking (between-person effects). In contrast, following child incarceration, women consumed alcohol less frequently and were less likely to binge drink than they were prior to experiencing child incarceration (within-person effects). Additional research should focus on mechanisms that explain these opposing associations to identify protective factors and institutional supports for women whose children have been incarcerated.
Exploring the coherence and divergence between the objective and subjective measurement of streetscape perceptions at the neighborhood level: A case study in Shanghai
Authors: Song Qiwei , Fang Yuxian , Li Meikang , van Ameijde Jeroen , Qiu Waishan
Published: October 2024

Understanding micro-level perceptions of street scenes is highly concerned with residents’ behaviors and socioeconomic outcomes. While many studies rely on objective measures, such as physical features extracted from Street View Imagery (SVI) to proxy perceptions using derived formulas, others employ subjective measures from visual surveys to capture more subtle human perceptions. We argue that the two measurements can diverge significantly over the same perception concept, which might lead to opposite spatial implications in policy if not properly understood. Moreover, as perceptions are often examined individually, few studies have investigated their joint distribution patterns to reflect perceptions’ multi-dimensional nature. To fill the gaps, we collected five pairwise perceptions from SVIs (i.e., complexity, enclosure, greenness, imageability, and walkability) at the neighborhood level in Shanghai. Each perception consists of pairwise values subjectively measured using a GeoAI-based approach and objectively quantified using formulas. We statistically and spatially compared the coherence and divergence of the two measures, further examining the perceptual differences. Advanced techniques including cluster analysis and factor analysis were employed to jointly evaluate their spatial distribution discrepancy. Our results revealed more differences than similarities between the two measures statistically and spatially, confirming any spatial implications concluded from one approach can vary significantly from the other. The joint spatial pattern further corroborated our conclusions. Our study enriches the literature on micro-level street perception measures, uncovers their critical differences to guide future comparative studies, and offers new approaches for urban perception mapping.
Implementation of Virtual, Livestream Yoga Classes for Veterans at Home During the COVID-19 Pandemic: A Mixed-Methods Pilot Program Evaluation
Authors: Pham Catherine , Hildebrand Caitlin , Tarasovsky Gary , Purcell Natalie , Seal Karen , Nicosia Francesca
Published: October 2024

Background

The COVID-19 pandemic and shut down of in-person complementary and integrative (CIH) wellness services at the San Francisco Veterans’ Affairs Healthcare System (SFVAHCS) required implementation of virtual program delivery. In May 2020, VA in-person group yoga classes pivoted to virtual classes for existing attendees. In October 2020, we partnered with SFVAHCS Integrative Health and the VA Office of Rural Health to formalize the TeleYoga Program to expand yoga access to Veterans in SFVAHCS’ geographically dispersed area.

Objective

This pilot study evaluated Veterans’ experiences and self-reported health outcomes after participating in at-home tele-yoga groups during the COVID-19 pandemic.

Methods

The RE-AIM framework guided program delivery evaluation. Reach was assessed with medical record data. Adoption was assessed by the number of new facilities providing referrals to tele-yoga. Implementation, satisfaction, and patient-reported outcomes, were evaluated through structured interviews with Likert scale and open-ended responses.

Results

We offered 4-6 weekly livestreamed classes between October 2020-September 2021. The program reached 70 Veterans, including 40 new participants, with 1208 total unique encounters. Referrals increased from 2 to 6 SFVAHCS facilities. Fourteen participants completed structured interviews. Over half rated highly the convenience and overall experience of tele-yoga classes and reported improvement with pain, stress management, exercise, and flexibility. Open-ended responses indicated opportunities for social connection, maintaining mental health, cultivating resilience, improving function, and managing pain. Suggestions for improvement focused on technological aspects, including audiovisual quality.

Conclusions

During the COVID-19 pandemic, we successfully transitioned and expanded virtual group yoga delivery to Veterans from all geographic locations within SFVAHCS. We attribute this success to existing infrastructure for telehealth and CIH services and a virtual program orientation for new participants. The results of this pilot study suggest in-person group yoga may be successfully implemented virtually, serving as a viable modality that contributes to holistic wellbeing for Veterans.
Visualising human life in volumetric cities: City digital twins and other disasters
Authors: Rose Gillian
Published: October 2024

City digital twins (CDTs) are attracting considerable attention as a tool for the management of cities facing many kinds of crises. CDTs are three-dimensional, animated digital models of cities that display the big data generated by urban sensors in near-real-time. Most of the academic literature on CDTs consists of technical discussions of their design or implementation. This paper instead proposes a different context for understanding CDTs. It adopts an intersectional feminist and techno-cultural analysis of the visual form of power enacted by CDTs, as exemplary of a much wider turn in contemporary visual culture towards visualising the world digitally in three dimensions. Many critical accounts of this visual and volumetric regime are attentive to the forms of corporealised human life that emerge in relation to the picturing of various volumes. This paper examines how CDTs visibly co-constitute a number of digitally-mediated forms of human life, including its user and its human inhabitants. The paper argues that, while both the technological affordances and the cultural imaginary of CDTs perform the kind of powerful white masculinity that sees space as transparent and actionable, discussions of CDTs also persistently generate an excessive form of human life that is understood as untwinnable. The paper argues that masculinist anxieties around this excess erupt in another form of digitally-animated volumetric city facing disaster: the disaster movie. The paper thus makes an argument about the specific form of white masculinity co-constituted with CDTs and insists on the necessity of critical techno-cultural analyses of urban management technologies.
Fuzzy Adaptive State Estimation of Distributed Drive Electric Vehicles with Random Missing Measurements and Unknown Process Noise
Authors: Zhang Zhiguo , Yin Guodong , Huang Chao , Hu Jingyu , Xu Xing , Jiang Chengyue , Wang Yan
Published: October 2024

Accurate estimation of sideslip angle and vehicle velocity is crucial for effective control of distributed drive electric vehicles. However, as these states are not directly measured, Kalman-based approaches utilizing in-vehicle sensors have been developed to estimate them. Unfortunately, existing methods tend to ignore the impact of data loss on estimation performance. Furthermore, the process noise, which changes dynamically due to varying driving conditions, is not adequately considered. In response to these constraints, we propose a novel method called the fuzzy adaptive fault-tolerant extended Kalman filter (FAFTEKF). Initially, a fault-tolerant EKF is devised to handle missing measurements. Additionally, a fuzzy logic system that dynamically updates the process noise matrix, is built to improve estimation accuracy under different driving conditions. Extensive experimental results validate the superiority of the FAFTEKF over the traditional EKF across various scenarios with different degrees of data loss.
ADAM8 promotes alcoholic liver fibrosis through the MAPK signaling pathway
Authors: Yang Mengli , Li Sanqiang , Luo Renli , Zhao Yadi , Sun Yue , Li Haoyuan , Cui Qinyi , Wu Junfei , Mao Longfei
Published: October 2024

The effect and molecular regulatory mechanism of A Disintegrin and Metalloproteinase 8 (ADAM8) were explored in alcoholic liver fibrosis (ALF). C57BL/6N male mice were randomly divided into control, alcohol, and ADAM8-sgRNA3 plasmid groups. The control group received control liquid diet, while the alcohol and ADAM8-sgRNA3 plasmid groups were given alcohol liquid feed diet combined with ethanol gavage treatment for 8 weeks to induce ALF modeling. In addition, the ADAM8-sgRNA3 plasmid group was injected with the effective ADAM8-sgRNA3 plasmid, while the alcohol and control group mice were injected with an equivalent amount of physiological saline. LX-2 human hepatic stellate cells were divided into control, alcohol, si-ADAM8-2, and si-ADAM8-NC groups and induced for 48 h for model establishment in vitro. Serological detection, pathological staining, Western blotting, qRT-PCR and CCK8 assay were performed for experiments. Compared with the alcohol group, ADAM8 mRNA, protein and, positive area rate, serological indicators, pathological changes, and the expression of liver fibrosis marker and MAPK signaling pathway-related factors in the ADAM8-sgRNA3 plasmid group significantly decreased in vivo. Compared with the alcohol group, ADAM8 mRNA and protein expression, cell viability, and the expression of liver fibrosis markers and MAPK signaling pathway-related factors (p-ERK1/2, PCNA, Bcl-2, p-c-Jun, TGFβ1, p–p38 MAPK and HSP27) reduced significantly in the si-ADAM8-2 group. Therefore, ADAM8 promotes ALF through the MAPK signaling pathway, a promising target for treating ALF.