bluuebunny/crossref_metadata_2025 huggingface dataset:
PrEstoCloud
Authors: Verginadis Yiannis , Apostolou Dimitris , Taherizadeh Salman , Ledakis Ioannis , Mentzas Gregoris , Tsagkaropoulos Andreas , Papageorgiou Nikos , Paraskevopoulos Fotis
Published: January 2021

Fog computing extends multi-cloud computing by enabling services or application functions to be hosted close to their data sources. To take advantage of the capabilities of fog computing, serverless and the function-as-a-service (FaaS) software engineering paradigms allow for the flexible deployment of applications on multi-cloud, fog, and edge resources. This article reviews prominent fog computing frameworks and discusses some of the challenges and requirements of FaaS-enabled applications. Moreover, it proposes a novel framework able to dynamically manage multi-cloud, fog, and edge resources and to deploy data-intensive applications developed using the FaaS paradigm. The proposed framework leverages the FaaS paradigm in a way that improves the average service response time of data-intensive applications by a factor of three regardless of the underlying multi-cloud, fog, and edge resource infrastructure.
TAM Model Evidence for Online Social Commerce Purchase Intention
Authors: Ying Zhang , Jianqiu Zeng , Akram Umair , Rasool Hassan
Published: January 2021

The aim of this research is to use the Technology Acceptance Model (TAM) to investigate the potential antecedents of online purchase intention in social commerce environments. Data were collected from 513 online survey participants in China. Structural Equation Modeling (SEM) techniques was used to test the study hypotheses. The findings reveal that website quality, trust, and electronic Word Of Mouth (eWOM) positively influence online purchase intentions. Furthermore, perceived ease of use and perceived usefulness significantly and positively moderate the relationship between website quality and online purchase intention. These survey results help provide a more comprehensive understanding of online purchase intentions in social commerce in China. The findings and conclusion address notable implications for theory and managers.
Low-Cycle Fatigue-Creep Interaction Behavior of GH4169 Supperalloy
Authors: Lian Ye Da , Gao Li Qiang , Yin Qian , Xu Zhuang Zhuang , Wen Zhi Xun
Published: January 2021

Effects of different loading and uninstalling and safe loading time on the low-cycle fatigue-creep interaction behavior of GH4169 superalloy at 650°C/850MPa have been investigated. The study found that under the safe loading time, with the longer the loading and unistalling time, the fatigue-creep property and life of this alloy were gradually improved. However, under the same loading and uninstalling time, with the extension of the loading time, property of the fatigue-Creep of the alloy was gradually reduced, and its life was gradually shortened. In addition, The fracture failure behavior of the alloy under different conditions was studied in detail. Interestingly, With the extension of the holding time, the fracture failure of the alloy was changed from fatigue damage to creep damage, which makes its fracture mode transition the transgranular fracture into intergranular fracture extension.
Evaluating Influences of Input Parameters on Surface Roughness in Sinking EDM Cylindrical Shaped Parts
Authors: Hong Tran Thi , Tuan Nguyen Anh , Danh Bui Thanh , Ky Le Hong , Linh Nguyen Hong , Giang Tran Ngoc , Pi Vu Ngoc , Cuong Nguyen Manh
Published: January 2021

The input parameters in the process of sinking Electrical Discharge Machining (EDM) are the essential enabling factors that need to be determined. In the present work, the influences of the EDM input parameters containing pulse on time (Ton), pulse off time (Toff), discharge current (IP), Server voltage (SV), work-piece diameter (dw) on the surface roughness (SR) in sinking EDM cylindrical shaped part of 9CrSi material were investigated. Taguchi technique and analysis of variance (ANOVA) have been used to identify the weight of EDM factors on SR. The results show that the impact level of Ton, Toff, IP, SP, and dware 65.55%, 8.66%, 19.17%, 3.14%, and 0.76%, respectively. By analyzing the experimental results, optimum input parameters with the Tonof 6 ms, Toffof 30 ms, IP of 9A, SP of 3V, and dwof 10mm have been determined, that allow getting the best surface roughness.
Efficacy of gluten-free diet in patients with rheumatoid arthritis
Authors: Bruzzese V. , Scolieri P. , Pepe J.
Published: January 2021

Recent research has increasingly shown that depending on the foods we eat, gut flora may be affected by an inflammatory or anti-inflammatory response, thus playing an important role in inflammatory autoimmune diseases, such as rheumatoid arthritis or gastroenterological disorders. Gluten seems to be a glycoprotein with a clinically relevant inflammatory effect. Several observational studies and anecdotal cases reported a correlation between gluten and various diseases, including autoimmune diseases, such as rheumatoid arthritis. This study aimed to evaluate whether gluten-free diet could be effective in controlling inflammation and ongoing rheumatoid arthritis symptoms. We report 4 cases of patients with long-standing rheumatoid arthritis with no response to several conventional and biotechnological drugs, treated with a gluten-free diet concurrently with the drug therapy. Our patients presented different degrees of response to the diet, in terms of disease remission and improvement of symptoms. Our cases confirm that a gluten-free diet may improve symptoms of rheumatoid arthritis, even in patients resistant to conventional drug therapies.
Vanishing of multizeta values over
at negative integers
Authors: Shi Shuhui
Published: January 2021

Let
$\mathbb {F}_q$
be the finite field of q elements. In this paper, we study the vanishing behavior of multizeta values over

$\mathbb {F}_q[t]$
at negative integers. These values are analogs of the classical multizeta values. At negative integers, they are series of products of power sums

$S_d(k)$
which are polynomials in t. By studying the t-valuation of

$S_d(s)$
for

$s < 0$
, we show that multizeta values at negative integers vanish only at trivial zeros. The proof is inspired by the idea of Sheats in the proof of a statement of “greedy element” by Carlitz.
Muslim Healers and Healing: An Ethnographic Study of Aboabo Community of Ghana
Authors: Adu-Gyamfi Samuel , Teikillah Abubakar , Nyaaba Ali Yakubu , Kuusaana Mariama Marciana , Darkwa Benjamin Dompreh , Tomdi Lucky
Published: January 2021

Societies that have accepted Islam have blended their native culture with what was, rightly and wrongly, linked to Islam. Here, we present an example of this combination concerning traditional healing processes in Muslim societies. Focusing on the Aboabo community, we did an ethnographic study of healing processes and rites used by healers and further discussed the rites, practices, contributions and challenges of Muslim traditional healing in the community. Based on a qualitative research approach, the current study uses both theories of diffusionism and syncretism and empirical evidence to highlight the mode of treating some diseases using medicinal plants and rituals including prayers and Qur‟an verses recommended in ancient narrations received from earlier Muslim societies (particularly Arab societies). Although Muslim traditional healers are nearly disappearing from many contemporary Muslim societies, the continuation of their presence in some societies such as Aboabo is partly related to the standard of living of the people. The know-how of these healers is mainly limited to their native traditions, some principles of Islam and related questionable narrations. The activities of Muslim traditional practice have remained archaic, often questionable and/or unhygienic despite Islam‟s exhortation of its believers to respect, among other things, cleanliness and hygiene, and especially to increasingly develop their knowledge in major areas such as those concerning medicine and anthropology. Finally, we realized that although the idea of modernization of Muslim traditional healing in Ghana is expressed in some local discourses, it remains at the periphery.

Keyword: Muslim, Islam, Aboabo community, Healing, Muslim healers, Traditional Medicine, Cultures
Evaluation of building security costs determinant within the built environment in Minna, Niger state, Nigeria
Authors: Anifowose M.O , Said I. , Idiake J.E , Ismail R
Published: January 2021

Building equipped with protective measures is exceedingly restricted but it brings about a moderately high increment in expenses of building security and the general cost of the home. This study aims at assessing the built environment experts’ perception of factors affecting the cost of maintaining security in houses as a part of sustainable building security cost. The study employed mixed methods sequential exploratory design to source data primarily from the respondents. Purposive and convenience sampling were used for data collection while descriptive statistics and inferential were employed for data analyses. The results revealed insignificant difference in respondents’ perceptions on building security costs. The top ranked respondents’ perceptions were from Builders, Quantity Surveyors and Architects with total mean scores of 267.08, 234.66 and 234.63. No significant variations were shown among the mean scores of the items ranked. This is an indication that all items are important therefore having effect on building security costs. The study concluded that external wall openings access prevention, size of building, perimeter fence and protection are some of the key criteria for measuring building security costs. The study sensitizes the built environment experts, criminologists and policy makers about the implication of the established factors on building security costs.

Keyword: Built-Environment, Building security, Cost determinant, Experts’ perceptions
Antidepressant effect of methanol root bark extract of Acacia seyal Del. (Fabaceae): Possible involvement of the inflammatory pathway
Authors: Shehu Aishatu , Anyip Bishio , Magaji Mohammed Garba
Published: January 2021

Purpose: To study the involvement of inflammatory pathways in the antidepressant activity of Acacia seyal in mice.Methods: The median lethal dose (LD50) of the extract Acacia seyal (AS) was determined using OECD guideline 425. The antidepressant activity of AS was assessed against BCG (0.2 mg/kg, ip)-induced depression in mice using Tail suspension test (TST) and open field test (OFT) at 4, 24 and 48  hours post BCG administration.Results: The median lethal dose (LD50) for the extract was > 5000 mg/kg orally. The extract AS at all tested doses (250 – 1000 mg/kg) significantly (p ≤ 0.001) decreased the duration of immobility in TST but increased the number of line crossing in OFT post-BCG.Conclusion: The antidepressant activity of the methanol root bark extract of Acacia seyal in mice may involve an inflammatory mechanism. Thus, the extract of Acacia seyal may be suitable for the management of depression in humans resistant to other conventional antidepressant agents. However, further studies are required to ascertain this

Keywords: Depression, Acacia seyal, Tail suspension test, Open field test, Bacillus Calmette-Guerin
Protective effect of erdosteine against methotrexateinduced hepatotoxicity in rats
Authors: Hassan Osama Abdelaziz , Amin Entesar Farghally , Moussa Rabab Ahmed
Published: January 2021

Purpose: To study the possible mitigating effect of erdosteine (ERD) against methotrexate (MTX)-induced liver toxicity.Methods: Male albino Sprague-Dawley rats were randomly assigned to four groups of 8 rats each, viz, vehicle control, MTX (20 mg/kg i.p.), MTX (20 mg/kg i.p.) + ERD (300 mg/kg) and ERD (300 mg/kg) groups. Serum levels of alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were determined by enzymatic colorimetric commercial kits while Hepatic tissue content of malondialdehyde (MDA), reduced glutathione (GSH), SOD and catalase (CAT) were also evaluated. In addition, measurement of the inflammatory cytokine, TNF-α, as well as histopathological  examination and histochemical assessment were carried out.Results: The results indicate that, compared to the control group, MTX group showed a remarkable elevation in oxidative stress as indicated by significantly lower levels of SOD, CAT and reduced glutathione, and increased tissue malondialdehyde (p < 0.05). MTX group exhibited significantly higher blood activities of ALT, AST and TNF-α, reflective of hepatocyte damage and inflammation (p < 0.05). In MTX group, significant hepatic degenerative changes were detected on histological examination, while marked apoptotic alternations were observed following  immunohistochemical analysis of caspase-3 expression, when compared to control group. However, administration of ERD to rats ameliorated thechanges in these parameters (p < 0.05).Conclusion: Treatment with ERD in rats produced alleviation in hepatic oxidative stress, apoptosis, inflammation, and histological damage, when compared to MTX group. This study is the first to demonstrate the potentially protective effect of ERD-pretreatment against hepatotoxicity associated with MTX.

Keywords: Erdosteine, Methotrexate, Hepatotoxicity, Oxidant, Anti-oxidant
Bioassay-guided optimization of lipid-based erythromycin microparticles
Authors: Nzekwe Ifeanyi T. , Okere Anselm C. , Okoye Ifeanyi E. , Ekere Kokonne E. , Ezenwa Adaobi A. , Agubata Chukwuma O.
Published: January 2021

Purpose: To optimize erythromycin microparticles by in vitro bioassay methods based on its antibacterial activity.

Methods: The microparticles were produced by high shear homogenization. The effects of different lipid-to-surfactant ratios were studied. The hydrodynamic size of the different batches was evaluated using dynamic light scattering while bioactive drug load per batch was assessed in agar using bioassay methods. The antimicrobial activities of selected batches were tested ex vivo by determination of reduction in bacteraemia following administration of the microparticles to infected animals.

Results: All batches had particles with hydrodynamic sizes < 8.5 microns. Batch 7 with a 2: 5: 2.5 (drug: surfactant: stearic acid) ratio, represents the optimized batch with a hydrodynamic size of 2281 nm, a bioactive drug loading capacity (BLC) of 4.67 ± 0.70 % and bioactive drug entrapment  efficiency (BEE) of 10.51 %. The “microparticle MIC” against Staphylococcus aureus was 1.74 x 10-3 μg/ml. Despite containing lower amounts of erythromycin than the pure sample, the microparticles achieved comparable reduction in bacteraemia, with the optimized batch exhibiting lower variation in bacteraemia than the pure drug.

Conclusion: Erythromycin microparticles have been successfully optimized with the aid of bioassay methods which has the advantage that only the bioactive drug concentration is factored in. This method eliminates problems posed by inadequate or non-discriminating chemical assay methods.

Keywords: Microparticles, Erythromycin, Gastrointestinal, Bioavailability Antimicrobial, Bioactivity, Encapsulation
An ethnopharmacological review of Hyptis suaveolens (L.) Poit
Authors: Li Rong , Tang Gengqiu , Liu Xile , Li Junni , Wang Dong , Ji Shengguo
Published: January 2021

This review aimed to provide a comprehensive overview of ethnobotanical uses, chemical constituents, posology, and toxicology of Hyptis  suaveolens, and to address the significant medicinal benefits in order to promote its application. An extensive and systematic review of the literature was undertaken and all relevant abstracts and full-text articles analyzed and included in the review. A wide range of traditional uses are cited in the literature, ranging from uses for malaria, constipation, stomach problems, renal inflammation to external uses in repelling insects and treating injuries such as lacerations and burnrelated damage to skin and tissues. To date, pharmacological studies have demonstrated the  significant activities of this plant that support uses such as antimicrobial, antidiabetic, antiulcer, and antiinflammatory. Numerous important phytochemicals, including 6 triterpenes, 8 diterpenes and 1 flavonoid have been isolated, identified and reported. The extracts and phytochemicals isolated from the plants show considerable potential for medicinal exploitation and utilization, including antimitotic, antiproliferative, cytotoxic, antioxidant, anti-inflammatory, antibacterial, antifungal, antiviral, anti-secretory, hepatoprotective, insecticidal, and acaricidal activities. As a medicinal plant, H. suaveolens is endowed with immense exploitation and utilization value and is widely used worldwide Therefore, further studies to fully elucidate its medicinal potential are warranted.

Keywords: Hyptis suaveolens (L.) Poit, Ulcer Antimicrobial Inflammation, Diterpenes, Traditional medicine, Ethnopharmacology, Lamiaceae
An overview of some medicinal plants and isolated active compounds with potential antiprotozoal activity
Authors: Ojuromi Oladele T. , Ashafa Anofi O.
Published: January 2021

Diarrhoea associated illness presents with mortality and morbidity in rural communities in most low income countries especially in children < 5 years of age. The continuous emergence of several opportunistic infections in immuno-compromised individuals has worsened the burden of diarrhoea in most of these countries. Protozoan infections caused by species of Cryptosporidium, Entamoeba spp. Giardia intestinalis, Blastocystis hominis and Trichomonas vaginalis have received insufficient attention because data on their prevalence and incidence are scanty. The commonly used drugs to treat infections caused by these organisms are becoming less effective due to the development of drug resistance. Evidence from literature has shown that natural products from medicinal plants are likely to be suitable alternatives and complimentary therapeutic drugs to combat most protozoan infections. Natural products and their bioactive compounds could be the solution to treat most protozoan infections that have developed resistance to these drugs. This review provides comprehensive information on the potential and limitations on activity of medicinal plants and their isolated compounds used in the treatment of protozoan diseases. Especially those considered as neglected diseases such as Cryptosporidium and other protozoans that are inadequately funded and possibility of lack of interest in drug developments have made them  receive little attention. Isolation and identification of bioactive natural products could be the ultimate panacea to cases of metronidazole resistance and discovery of effective and novel drug for Cryptosporidium infection which is currently suffering inadequate treatment options.

Keywords: Protozoan parasites, Diarrhoea, Neglected diseases, Medicinal plants, Bioactive compounds
Elucidation of the mechanisms underlying the anticholecystitis effect of the Tibetan medicine “Dida” using Network pharmacology
Authors: Liu Chuan , Fan Fang-Fang , Li Xuan-Hao , Wang Wen-Xiang , Tu Ya , Zhang Yi
Published: January 2021

Purpose: To study the mechanism involved in the anti-cholecystitis effect the Tibetan medicine “Dida”, using network pharmacology-integrated molecular docking simulationsMethods: In this investigation, the bioactive compounds of Dida were collected, network pharmacology methods to predict their targets, and networks were constructed through GO and KEGG pathway analyses. The potential binding between the bioactive compounds and the targets were demonstrated using molecular docking simulations.Results: A total of 12 bioactive compounds and 50 key targets of Dida were identified. Two networks, namely, protein-protein interaction (PPI) network of cholecystitis targets, and compound-target-pathway network, were established. Network analysis showed that 10 targets (GAPDH, AKT1, CASP3, EGFR, TNF, MAPK3, MAPK1, HSP90AA1, STAT3, and BCL2L1) may be the therapeutic targets of Dida in cholecystitis. Analysis of the KEGG pathway indicated that the anti-cholecystitis effect of Dida may its regulation of a few crucial pathways, such as apoptosis, as well as toll-like  receptor, T cell receptor, NOD-like receptor, and MAPK signaling pathways. Furthermore, molecular docking simulation revealed that CASP3, CAPDH, HSP90AA1, MAPK3, MAPK1, and STAT3 had well-characterized interactions with the corresponding compounds.Conclusion: The mechanism underlying the anti-cholecystitis effect of Dida was successfully predicted and verified using a combination of network pharmacology and molecular docking simulation. This provides a firm basis for the experimental verification of the use of Dida in the treatment of cholecystitis, and enhances its rational application in clinical medication.

Keywords: Tibetan medicine, Dida, Cholecystitis, Mechanism of effect, Network pharmacology, Molecular docking simulation
Apoptotic effect of astaxanthin from white shrimp shells on lung cancer A549 cells
Authors: Tanasawet Supita , Sukketsiri Wanida , Chonpathompikunlert Pennapa , Chonpathompikunlert Pennapa , Klaypradit Wanwimol , Sroyraya Morakot , Hutamekalin Pilaiwanwadee
Published: January 2021

Purpose: To investigate the anti-cancer potential of astaxanthin from Litopenaeus vannamei encapsulated in liposomes (ASX) to treat lung cancer A549 cells.Methods: Lung adenocarcinoma A549 cells were cultured and treated with ASX, following which cell viability and nuclear staining were performed. Generation of ROS was identified by the DCFH-DA assay while tetramethylrhodamine ethyl ester was used to determine the mitochondrial membrane potential. Flow cytometry was applied to investigate caspase-3/7 activity and cell cycle distribution.Results: ASX inhibited growth of A549 in a concentration- and time- dependent manner. The IC50 values at 24, 48 and 72 h were 53.73, 22.85, 17.46 μg/mL, respectively (p < 0.05). After incubation with ASX, the morphological changes were observed in A549 cells following Hoechst 33342/PI fluorescent staining. ASX increased ROS generation and was associated with the collapse of mitochondrial membrane potential, which subsequently triggered the activation of caspase-3/7 activity leading to apoptosis (p < 0.05). In addition, A549 cells accumulated in the G0/G1 phase.Conclusion: The results suggest that ASX is a valuable nutraceutical agent to target A549 lung cancer cells via ROS-dependent pathway as well as blockage of cell cycle progression.

Keywords: Astaxanthin, Litopenaeus vannamei, Lung cancer, A549, Apoptosis
MiR-379 inhibits proliferation and induces apoptosis in multiple myeloma by targeting Y-box binding protein 1
Authors: Wang Yunyun , Ji Dexiang , Chen Guoan
Published: January 2021

Purpose: To determine the effect of miR-379 in multiple myeloma.Methods: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to evaluate the expression of miR-379 in multiple myeloma cells. The effect of miR-379 on multiple myeloma progression was investigated by cell counting, bromodeoxyuridine staining, flow cytometry and Western blot analysis. A potential target for miR-379 was determined using a luciferase reporter assay.Results: MiR-379 expression was reduced in multiple myeloma cells, while over-expression of miR-379 increased both cell viability and proliferation of these cells (p < 0.05). Moreover, miR-379 blocked cell cycle multiple myeloma cells and promoted apoptosis by decreasing Bcl-2 expression, and increasing the expression of cleaved caspase-3 and Bax. MiR-379 bound to Y-box binding protein 1 (YBX1) and reduced YBX1 mRNA and protein expression in multiple myeloma cells (p < 0.05).Conclusion: A YBX1-mediated tumor-suppressive role for miR-379 in multiple myeloma cells has been identified, suggesting a potential strategy for the treatment of multiple myeloma.

Keywords: MiR-379, Y-box binding protein 1, Multiple myeloma, Proliferation, Apoptosis
Clinical value of soluble suppression of tumourigenicity 2 (sST2) in addition to NTproBNP measurements in a general cardiac outpatient population
Authors: Ammann Camille , Wyss Christophe , Gämperli Oliver , Wenaweser Peter Martin , Corti Roberto , Noll Georg , Biaggi Patric
Published: January 2021

BACKGROUND AND AIMS: The soluble form of suppression of tumourigenicity 2 (sST2), a recently introduced biomarker, is a strong and NTproBNP-independent predictor of outcome in heart failure patients. This study sought to evaluate the added clinical value of sST2 in addition to NTproBNP in a heterogeneous cardiac outpatient population.

METHODS: A total of 297 all-comer patients visiting the outpatient clinic of Heart Clinic Zurich, Switzerland, from January to December 2018 were included. Patients were divided into four groups depending on their sST2 and NTproBNP levels: group 1 (n = 91, 30.6% of all patients) with normal levels of both biomarkers, group 2 (n = 41, 13.8%) with isolated elevation of sST2 but normal NTproBNP, group 3 (n = 97, 32.7%) with elevated NTproBNP but normal sST2 levels, and group 4 (n = 68, 22.9%) with elevation of both biomarkers. Differences between groups, Spearman’s correlations and linear and multiple regression analysis for sST2 were calculated.

RESULTS: The median age was 74 ± 19 years and 41.8% were women. NTproBNP levels continuously increased across the groups (medians in pg/ml: group 1 123.0, group 2 152.0, group 3 990.0 and group 4 2610.0), whereas sST2 levels did not (medians in ng/ml: 28.7, 58.9, 28.4 and 63.7 for groups 1 to 4, respectively). In patients with normal NTproBNP (groups 1 and 2), elevation of sST2 (group 2) was associated with significantly higher rates of coronary artery disease, peripheral vascular disease and renal dysfunction. In patients with elevated NTproBNP (groups 3 and 4), the additional elevation of sST2 (group 4) was associated with clinical signs of heart failure, higher EuroScore II and worse left ventricular ejection fraction (LVEF group 3 58.0% vs group 4 53.3%, p = 0.022). Correlation of sST2 was overall weak and weaker than of NTproBNP with most clinical variables. Soluble ST2 significantly correlated with EuroScore II (R = 0.280), kidney function (R = −0.259), C-reactive protein (R = 0.248), right ventricular function (R = 0.213) and left atrial volume (R = 0.199), all p ≤0.001. In multiple regression analysis, left atrial volume was the strongest independent predictor of sST2 elevation (p = 0.002).

CONCLUSION: In this all-comer cardiology population, the added clinical value of sST2 measurements in addition to NTproBNP was small. In patients with elevated NTproBNP, the simultaneous elevation of sST2 was associated with clinical signs of heart failure. Soluble ST2 measurements could thus be beneficial in patients with uncertain signs of heart failure and confounding factors for NTproBNP elevation. Surprisingly, this study found elevated sST2 levels in a substantial number of a patients with normal NTproBNP levels, pointing to an additional pathway of sST2 elevation independent of heart failure.
Productivity loss and indirect costs in the year following acute coronary events in Switzerland
Authors: Mach François , Lyrer Philippe , Hullin Roger , Dwan Bernadetted , Wanger Cindy , Reichert Nina , Sidelnikov Eduard , Konstantinos Koskinas
Published: January 2021

Acute coronary syndrome (ACS) is highly prevalent in Switzerland and a leading cause of death. Associated productivity loss and indirect costs have rarely been studied. We investigated these factors in the first year after ACS in 24 Swiss patients (mean (SD) age 56 (8) years, 79% male). Data on patient productivity loss, absenteeism, presenteeism and caregiver assistance, were collected with the Productivity Cost Questionnaire during a routine cardiologist visit 3 to 12 months after hospitalisation for ACS and at least 4 weeks after patients returned to work. To estimate costs, lost hours were converted into 8-hour workdays, pro-rated to 1 year, combined with time off work due to initial hospitalisation and sick leave, and valued at Swiss labour costs. Additional data came from medical records. ACS patients lost on average (SD, range) 79 (81, 0.3–294) workdays; 38 (36, 0.3–153) days due to the initial hospitalisation and sick leave, 37 (75, 0–243) due to absenteeism after patients returned to work, and 4 (11, 0–41) due to presenteeism. Caregivers lost 10 (23, 0–90) additional workdays. The total indirect costs amounted to CHF 43,205 (44,026, 122–148,648); including CHF 18,514 (17,507, 122-74,619) for initial hospitalisation and sick leave and CHF 17,988 (36,394, 122–143,277) and CHF 1,849 (5181, 0–20,158) for absenteeism and presenteeism after patients returned to work, respectively. Costs of caregiver assistance amounted to CHF 4,855 (11,015, 0–43,843). This study showed that ACS patients lost on average 36% of their annual productive time. Caregivers lost an additional 5%. Lost work time was associated with substantial indirect costs that exceeded estimates of direct costs for ACS during 1 year. This suggests that costs and burden could be reduced through better risk reduction management.
MÔ PHỎNG ĐẶC TÍNH KHÍ ĐỘNG LỰC HỌC TRÊN DÒNG XE SUV
Authors: TIẾN PHÚC ĐẶNG
Published: January 2021

Bài báo này trình bày nghiên cứu đặc tính khí động lực học ô tô thông qua phân tích mô hình ô tô SUV. Tác giả sử dụng phần mềm thương mại CFD với phương trình RANS kết hợp mô hình rối Realizable k  để mô phỏng đặc tính khí động lực học mô hình ô tô SUV. Bài báo trình bày phương pháp và kết quả mô phỏng sự phân bố áp suất, sự phân bố vận tốc và vectơ vận tốc quanh mô hình. Khu vực đầu xe, nắp capo, mui xe và đuôi xe ảnh hưởng nhiều đến lực cản khí động lực học. Kết quả nghiên cứu được thể hiện thông qua các hình ảnh và giá trị mô phỏng tính toán Cd, đồng thời giúp hiểu rõ hơn đặc tính khí động lực học quanh mô hình ô tô SUV
REFERENCE MODEL FOLLOWING SLIDING MODE CONTROL FOR ACTIVE SUSPENSION SYSTEMS
Authors: VIỄN QUỐC NGUYỄN
Published: January 2021

In the design passive suspension systems, there is a trade-off between the performance under bump input and that under high frequencies input due to high speed driving. In this work, a reference-model following sliding mode control (RMF-SMC) is proposed for active suspension systems in order to obtain high-performance suspension and vibration isolation in the frequency range that causes bad effects on human. In the proposed control algorithm, a sliding surface is defined based on the ideal skyhook dynamic such that the system exhibits its good suspension and vibration isolation characteristics once the system enters the sliding mode. Computer simulations are implemented to evalute the effectiveness of the proposed control algorithm.
NGHIÊN CỨU THỰC NGHIỆM XÁC ĐỊNH ẢNH HƯỞNG CỦA VẬN TỐC TÁC NHÂN SẤY ĐẾN SẤY ĐƯỜNG RS TRÊN MÔ HÌNH SẤY TẦNG SÔI LIÊN TỤC CẤP KHÍ KIỂU XUNG
Authors: TRUNG THÀNH BÙI , QUANG PHÚ PHẠM
Published: January 2021

Nghiên cứu sấy đường RS được thực hiện bằng thực nghiệm đơn yếu tố trên mô hình sấy tầng sôi cấp khí kiểu xung có năng suất 20kg/giờ. Thực nghiệm được thực hiện trong điều kiện vận tốc tác nhân được điều chỉnh vg=1-3m/s trong khí 4 thông số công nghệ được bố trí cố định gồm: chiều cao lớp hạt trợ sôi H0 = 65mm, đường kính hạt dp = 0,8mm, nhiệt độ tác nhân sấy tg = 70Oc; tần số cấp khí xung f = 0,5Hz . Kết quả thực nghiệm cho độ ẩm sản phẩm M2=0,06% (phù hợp theo TCVN 6958: 2001), tiêu hao nhiệt lượng riêng q=1008 kJ/kg sản phẩm; tiêu hao điện năng riêng N=194Wh/kg sản phẩm và tỷ lệ thu hồi sản phẩm h =88,8%.Dựa trên kết quả phân tích thực nghiệm đơn yếu tố về mối quan hệ tương quan giữa 4 thông số công nghệ (t,H0,dp,f) ảnh hưởng đến 4 hàm mục tiêu (M2,q,N, h), của chế độ sấy tầng sôi xung khí với hạt đường RS, tác giả đã xác định được chế độ sấy hợp lý gồm nhiệt độ sấy tg= 75OC,tần số xung khí f=0,6 Hz ,dp =0,4 mm thì vận tốc tác nhân là 2,2 m/s.
TÍNH TOÁN VÀ THỰC NGHIỆM XÁC ĐỊNH THÔNG SỐ ĐỘ BỀN TẤM PANEL CHẾ TẠO BẰNG VẬT LIỆU COMPOSITE POLYESTER - SỢI THỦY TINH
Authors: XUÂN KHOA HUỲNH , CAO NGUYÊN KHANG CHÂU
Published: January 2021

Bài báo giới thiệu nghiên cứu tính toán và thực nghiệm xác định thông số độ bền cho tấm panel làm bằng vật liệu composite Polyeste- sợi thủy tinh kết cấu sandwich. Các thông số bao gồm ứng suất bền kéo (σk), module đàn hồi (E) của các thành phần cấu tạo nên tấm panel được tính dùng mô hình toán họcthực hiện trên phần mềm Mathworks MATLAB R2018a chạy trên MS Window 10 và được kiểm chứng bằng phương pháp thực nghiệm trên máy thử kéo. Kết quả cho thấy độ tương hợp cao giữa mô hình đã chọn và phương pháp thực nghiệm tạo cơ sở cho việc tính toán toàn bộ kết cấu của tấm panel.
STUDYING THE EFFECT OF STATIC MAGNETIC FIELDS TO FREEZING TIME FOR VIETNAMESE CATFISH (PANGASIUS) FILLETS
Authors: THỊ TÂM THANH NGUYỄN , QUANG PHÚ PHẠM , HỒNG HẢI ĐOÀN THỊ , CHÍ CHÍNH VÕ , THÀNH VĂN NGUYỄN
Published: January 2021

The main objective of paper is to study the effect of static magnetic fields to the freezing time for the Vietnameses catfish (Pangasius) fillets. In this study, the catfish fillets were considered with an average size of 210x80x15mm (length x width x thickness). They were frozen from 12°C to -18°C (center temperature) in a medium temperature of -40°C, -35°C and -30°C with air velocity of 5m/s in two different methods: the conventional air blast freezing (ABF) and the innovation air blast freezing assisted static magnetic fields (SMF) with 431, 453, 499 and 528 Gauss to study the influence of static magnetic fields to freezing time. At the same air freezing temperature, the freezing time with SMF decrease from 34% to 56% compared to the ABF when the magnetic density increases from 431 Gauss to 528 Gauss. This shows the innovation freezing assisted static magnetic fields may influence positively the decreasing of freezing time to save energy as well as the improving of quality for the Vietnamese catfish fillets.
NGHIÊN CỨU TỔN THƯƠNG CON NGƯỜI TRONG XE KHÁCH GIƯỜNG NẰM XẢY RA VA CHẠM LẬT NGHIÊNG
Authors: THÀNH TÂM NGUYỄN
Published: January 2021

Nghiên cứu này dựa vào tiêu chuẩn an toàn FMVSS 214 và ECE R66, sử dụng phần mềm HYPERWORKS và MADYMO tiến hành xây dựng mô hình và mô phỏng phân tích tổn thương con người trong xe khách giường nằm xảy ra va chạm lật nghiêng. Kết quả mô phỏng cho thấy, gia tốc va chạm cao làm cho con người bị tổn thương phần đầu, ngực, bụng rất nghiêm trọng. Nguyên nhân chủ yếu là do không trang bị dây đai an toàn hoặc hệ thống dây đai không đảm bảo tại những vùng nguy hiểm. Trên cơ sở kết quả phân tích cơ chế tổn thương hành khách, tiến hành cải tiến hệ thống dây an toàn. Kết quả cải tiến cho thấy, các giá trị tổn thương của hành khách đều thỏa mãn yêu cầu của tiêu chuẩn FMVSS 2
NGHIÊN CỨU THỰC NGHIỆM XÁC ĐỊNH ẢNH HƯỞNG CỦA TẦN SỐ XUNG KHÍ ĐẾN QUÁ TRÌNH SẤY ĐƯỜNG RS TRÊN MÔ HÌNH SẤY TẦNG SÔI LIÊN TỤC CẤP KHÍ KIỂU XUNG BẰNG PHƯƠNG PHÁP THỰC NGHIỆM
Authors: TRUNG THÀNH BÙI
Published: January 2021

Nghiên cứu được thực hiện trên mô hình sấy tầng sôi liên tục cấp khí kiểu xung có năng suất 20kg/giờ. Thực nghiệm được thực hiện trong điều kiện tần số cấp khí kiểu xung được điều chỉnh phạm vi f=0,1-0,9 Hz, trong khí 4 thông số sấy khác được cố định : chiều cao lớp hạt khô trợ sôi H0 = 65mm, đường kính trung bình của hạt dp = 0,8mm, nhiệt độ tác nhân sấy tg = 70Oc và vận tốc tác nhân sấy vg= 2m/s. Kết quả thực nghiệm đã xác định tần số cấp khí kiểu xung f= 0,6 Hz cho giá trị độ ẩm sản phẩm M2=0,05% (phù hợp theo TCVN 6958:2001); tiêu hao điện năng N=203 Wh/kg sản phẩm; tiêu hao nhiệt lượng riêng q= 955 kJ/kg sản phẩm và hiệu suất thu hồi chính phẩm h =91%. Khí ở tần số cấp khí kiểu xung thấp hơn hay cao hơn đều làm cho M2, q,N tăng lên. Như vậy tần số cấp khí xung được chọn ở mức 0,6 Hz cho quá trình sấy đường RS trên mô hình sấy tầng sôi liên tục cấp khí kiểu xung
Approche hiérarchique d’extraction des compétences dans des CVs en format PDF
Authors: Flambeau Jiechieu Kameni Florentin , Tsopze Norbert
Published: January 2021

The aim of this work is to use a hybrid approach to extract CVs' competences. The extraction approach for competences is made of two phases: a segmentation into sections phase within which the terms representing the competences are extracted from a CV; and a prediction phase that consists from the features previously extracted, to foretell a set of competences that would have been deduced and that would not have been necessary to mention in the resume of that expert. The main contributions of the work are two folds : the use of the approach of the hierarchical clustering of a résume in section before extracting the competences; the use of the multi-label learning model based on SVMs so as to foretell among a set of skills, those that we deduce during the reading of a CV. Experimentation carried out on a set of CVs collected from an internet source have shown that, more than 10% improvement in the identification of blocs compared to a model of the start of the art. The multi-label competences model of prediction allows finding the list of competences with a precision and a reminder respectively in an order of 90.5 % and 92.3 %. .

L’objectif de ce travail est d’utiliser l’approche héirarchique d’extraction des informations dans le CV pour en extraire les compétences. L’approche d’extraction des compétences proposée s’effectue en deux grandes phases : une phase de segmentation du CV en sections classées suivant leurs contenus et à partir desquelles les termes représentant les compétences (compétences de bases) sont extraits; et une phase de prédiction qui consiste à partir des caractéristiques extraites précédemment, à prédire un ensemble de compétences qu’un expert aurait déduites, et que ces compétences ne seraient pas nécessairement mentionnées dans le CV (compétences implicites). Les principales contributions de ce travail sont : l’utilisation de l’approche hiérarchique de segmentation du CV en sections pour extraire les compétences dans le CV; l’amélioration de la l’approche de segmentation des CV; enfin, l’utilisation de l’approche binary relevance de classification multi-label pour prédire les compétences implicites du CV. Les expérimentations effectuées sur un jeu de CVs collectés sur Internet ont montré une amélioration de la précision de l’identification des blocs de plus de 10% comparé à un modèle de l’état de l’art. Aussi, le modèle de prédiction multi-label des compétences, permet de retrouver la liste des compétences avec une précision et un rappel respectivement de l’ordre de 90,5% et 92,3%.
Über die Wahrscheinlichkeit des Aussterbens einer Population in einer langsamen periodischen Umgebung
Authors: Bacaër Nicolas , Lobry Claude , Sari Tewfik
Published: January 2021

Wir studieren die Wahrscheinlichkeit des Aussterbens eines linearen Geburts- und Todesprozesses mit mehreren Typen in einer periodischen Umgebung, wenn die Periode groß ist. Diese Wahrscheinlichkeit hängt von der Jahreszeit ab und zeigt eine Diskontinuität im Zusammenhang mit einem "Canard" in einem langsam-schnellen dynamischen System. Der Diskontinuitätspunkt wird in einem Beispiel mit zwei Typen genau bestimmt. Dieses Beispiel kommt von einem Modell für eine Krankheit, die durch Vektoren übertragen wird.

We study the probability of extinction of a population modelled by a linear birth-and-death process with several types in a periodic environment when the period is large compared to other time scales. This probability depends on the season and may present a sharp jump in relation to a "canard" in a slow-fast dynamical system. The point of discontinuity is determined precisely in an example with two types of individuals related to a vector-borne disease transmission model.

On s'intéresse à la probabilité d'extinction d'un processus linéaire de naissance et de mort avec plusieurs types dans un environnement périodique dans la limite d'une période très grande. Cette probabilité dépend de la saison et peut présenter à la limite une discontinuité en lien avec un canard dans un système dynamique lent-rapide. On détermine précisément le point de discontinuité dans un exemple avec deux types d'individus provenant d'un modèle de transmission d'une maladie à vecteurs.
La recherche en Management du Sport en « francophonie » : L’avènement d’un écosystème
Authors: Bouchet Patrick
Published: January 2021

This paper aims to synthesize research on the Management of Sports Organizations (MOS) in France. Three parts structure this voluntarily simplifying contribution, very personal and collective at the same time through the direct and indirect contributions of many researchers. First of all, two historical parts between the 1960s and the 2000s provide a first disciplinary and then thematic perspective in order to make a French-speaking retrospective of the dynamics of scientific production. A last part in the form of a conclusion and an opening seeks to characterize the recent dynamics of MOS research (specialization, interaction, diversification) according to disciplines and/or objects of study. From this point of view, it constitutes a call for contributions that could be added progressively through the electronic format of the S2MS journal: Management & Organisations du Sport.
Stress Classification Using K-means Clustering and Heart Rate Variability from Electrocardiogram
Authors: Kang Mingu , Shin Siho , Jung Jaehyo , Kim Youn Tae
Published: January 2021

In this study, we propose a method to classify individuals under stress and those without stress using k-means clustering. After extracting the R and S peak values from the ECG signal, the heart rate variability is extracted using a fast Fourier transform. Then, a criterion for classifying the ECG signal for the stress state is set, and the stress state is classified through k-means clustering. In addition, the stress level is indicated using the 𝐑 − 𝐒𝐩𝐞𝐚𝐤 value. This method is expected to be applied to the U-healthcare field to help manage the mental health of people suffering from stress.
Clearing Break Points of Overcurrent Protection Coordination for Parallel Distribution Feeder
Authors: Elsadd Mahmoud A. , Taalab Abdel-Maksoud I. , Kawady Tamer A. , Elkalashy Nagy I.
Published: January 2021

This paper presents a modified overcurrent protection system to overcome the break points of a parallel distribution feeder protection. For realizing an appropriate protection setting, two concepts are introduced, and their performance is evaluated. These concepts are the adaptive coordination exploiting smart grid information and the modified coordination methods. The modified coordination is adjusted with changing of the contemporary worst fault point. A comparative study is done between the adaptive, modified, and conventional coordination concepts. For investigation purposes, a 11 kV distribution feeder is modelled using the Matlab/Simulink package. The results provide evidence of the efficacy of the proposed modified coordination concept for parallel distribution feeders.
O Impacto dos Aplicativos de Mobilidade nas Locadoras de Automóveis Brasileiras
Authors: Sbabo Ariele , Rosa Gullo Maria Carolina
Published: January 2021

Diante de um cenário econômico pós-crise, o surgimento dos aplicativos de mobilidade pode ocasionar um aumento em suas receitas do setor de locação de automóveis. O presente trabalho foi elaborado com o intuito de identifi car os impactos dos Aplicativos de Mobilidade nas Locadoras de Automóveis Brasileiras. Para isso, torna-se necessário revisar os conceitos de teoria da fi rma, oferta e demanda, comportamento do consumidor e economia compartilhada. A partir de dados de faturamento divulgados pelas empresas em bolsas de valores, utiliza-se o método de correlação Pearson (r) para verifi car a relação entre as variáveis e se realmente há impacto. O resultado foi positivo, já que a correlação foi próxima a 1, mostrando que sim, o surgimento da Uber impactou positivamente para o faturamento das locadoras de automóveis. Porém, existem outros fatores que podem infl uenciar o crescimento no faturamento, como revenda de seminovos e gestão de frotas. Devido a utilização de dados divulgados em bolsa, sem divisão da receita, conclui-se que o surgimento dos aplicativos de mobilidade impactou no crescimento do setor de locação de automóveis, mas não se pode mensurar esse impacto.
Rediseño organizacional en la gestión institucional
Authors: Jiménez Ubillús Víctor Manuel
Published: January 2021

Se desarrolla una aproximación al rediseño organizacional desde un análisis teórico científi co para evidenciar su importancia en la gestión institucional, considerando la necesidad de las organizaciones, impactadas por procesos de índole global, requieren adaptarse a contextos cambiantes y asumir el reto de continuar generando valor a sus actividades. Además de conocer la teoría del diseño organizacional, se busca exponer críticamente la posición de los autores e integrar la información hacia el planteamiento de una propuesta aplicable a las organizaciones inmersas en un entorno cambiante que requieren un tratamiento fl exible y contextualizado. Los alcances a los que se ha llegado, orientan el conocimiento y la aplicación de la teoría organizacional con el fi n de mejorar los procesos y asegurar el cumplimiento de los objetivos mediante la propia actividad de la organización, teniendo como base su estructura y su contexto.
Management of Post Prostatectomy Urinary Incontinence
Authors:   Department of Surgery, Federal Medical Centre Katsina, Nigeria, Muhammad Ujudud Musa
Published: January 2021

Urinary incontinence is an involuntary loss of urine which can be very distressing to the patient and the relatives. The prostatic surgeries are among the common urologic procedures worldwide with it attendant consequences one of which is urinary incontinence and the commonest types of urinary incontinence after prostatectomy is stress urinary incontinence. With the advent of increase in dexterity because of use of modern surgical armamentarium ranging from finer and more précised instruments to minimally invasive procedures to robotic prostatectomy the risk of urinary incontinence is decline, Urinary incontinence is commonly seen in patients with early prostate cancer who have open radical prostatectomy usually due to increased risk of damaging the external sphincter, the stress incontinence seen in post radical prostatectomy requiring more than one pad per day is up to 5% of patients beyond six months, this is due to damage or injury to the external sphincter during division and control of dorsal vein complex bleeding but it can be as low as 0-1% post robotic radical prostatectomy, however in total incontinence the incidence is less than 3%. Sound knowledge of anatomy, adequate lightening and exposure with meticulous tissue handling goes a long way in reducing the chances of this distressing problem not only to the patient and his relatives but also to the surgeon. Although some studies have shown no much difference in terms of post prostatectomy urinary incontinence between open and laparoscopic radical prostatectomy in a high volume centre, however the use of robotic prostatectomy using the davinci system has a better outcome because one can operate through a few centimeters small incision with a magnified 3Dimentional high definition vision system with tiny wristed instruments that bend and rotate far greater than human wrist.
Sepsis in a Young Man with Thalassemia Major: A Case Report
Authors:   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey, Burcin Atak , Gulali Aktas ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey, Tuba Duman ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey, Zahid Kocak ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey, Edip Erkus ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey, Haluk Savli ,   Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey
Published: January 2021

A 23-year-old young man with a transfusion-dependent thalassemia major presented to internal medicine outpatient clinic of our institution. His complaints included fatigue and abdominal pain for 1-2 days. He needed blood transfusions in every two weeks. On admission, he had a fever that not responded to empiric antibiotics. General condition of the patient deteriorated rapidly and he died in intensive care unit of our institution. In conclusion, physicians should aware of serious infectious caused by such microorganisms in patients with iron overload and proper antimicrobial therapy should be initiate at once.