bluuebunny/crossref_metadata_2025 huggingface dataset:
Автоматизоване тестування як засіб оцінювання рівня знань здобувачів вищої освіти
Authors: Вронський С. В. , Андрашко Ю. В.
Published: June 2024

В статтi розглянуто переваги та недолiки автоматизованого методу тестування для
оцiнки знань здобувачiв вищої освiти. Також висвiтленi можливi альтернативи модернiзацiї
даного методу у майбутньому. Враховуючи поступову iнформатизацiю суспiльства в
глобальному масштабi, даний пiдхiд дозволить пiдвищити якiсть механiзму оцiнки знань
учнiв — майбутнiх здобувачiв вищої освiти.
Reflexiones sobre el Derecho Internacional del Medio Ambiente para proteger a los ecosistemas: de la distopía a la utopía
Authors: Gil Gandía Carlos
Published: June 2024

Ante la situación de la degradación medioambiental y la emergencia climática actual, la cual se manifiesta año tras año en los informes científicos sobre cambio climático y salud de los ecosistemas, el Derecho Internacional del Medio Ambiente constituye un mecanismo idóneo para hacer frente a la catastrófica y urgente situación. Sin embargo, los parámetros jurídico-culturales hegemónicos en el citado Derecho han concedido a los ecosistemas como un objeto para el beneficio humano. En este trabajo se analiza la configuración jurídica y axiológica de este Derecho desde una perspectiva crítica, con la finalidad de reflexionar sobre otro derecho ambiental que proteja de forma más adecuada y eficaz el medioambiente, de conformidad con un paradigma ecológico, no antropocéntrico.
Avaliação microbiológica da carne bovina moída nas redes de supermercados de Canoinhas/SC
Authors: Rosina Angelica , Monego Fernanda
Published: June 2024

A carne é um ótimo meio para o crescimento de micro-organismos e pode ser responsável pela transmissão de bactérias patogênicas ao homem. O presente trabalho buscou avaliar as condições higiênico-sanitárias da carne moída bovina, proveniente de bancadas frigoríficas comercializadas em cinco supermercados no município de Canoinhas, estado de Santa Catarina. Foram analisadas oito amostras no período de outubro de 2012 a maio de 2013. As análises microbiológicas realizadas foram à pesquisa de Salmonella sp., determinação de coliformes totais, coliformes termotolerantes (NMP/g) e contagem de Staphylococcus aureus (UFC/g). As análises microbiológicas revelaram que não ocorreram diferenças significativas entre as amostras de carne moída dos cinco supermercados. Os resultados encontrados indicam um crescimento acima de 1,1x10³ NMP/g em 47,5% das amostras para coliformes totais, sendo que 57,5% destas foram identificadas como E. coli. Houve presença de S. aureus em 95% das amostras. Todas as amostras analisada apresentaram ausência total de Salmonella sp., estando em conformidade com a legislação brasileira.
Plano para redução de carga poluidora em indústria de lacticínios
Authors: Begnini Beatriz Chinato , Ribeiro Heraldo Baialardi
Published: June 2024

Os laticínios, em seu processo industrial, utilizam grande quantidade de água, o que provoca um aumento considerável no volume de efluente a ser tratado. Este trabalho teve como objetivo identificar os pontos de geração do efluente bruto numa empresa de laticínios, propondo uma tentativa de modificação no comportamento dos funcionários e conscientização das conseqüências ambientais para melhoria da eficiência do sistema de tratamento de efluentes. Para atender tais objetivos foi realizada a aplicação de um questionário, juntamente com as análises. A metodologia adotada consistiu em coletar amostras de efluente bruto para os parâmetros analisados. As amostras foram coletas sempre no mesmo ponto em diferentes dias e variação na carga poluidora. Os resultados demonstraram que os parâmetros tiveram variações atingindo altos índices de concentração do efluente bruto analisado.
Avifauna em fragmentos florestais no município de Rio Negrinho, estado de Santa Catarina
Authors: Hubner Daniela , Povaluk Maristela
Published: June 2024

Esta pesquisa teve por finalidade, identificar as aves encontradas em fragmentos de reflorestamento comercial com mata nativa em uma propriedade particular do bairro São Pedro em Rio Negrinho, SC. Primeiramente foram constatadas as espécies de aves que frequentam as áreas de reflorestamento comercial de pinus e eucalipto e as áreas de vegetação nativa. Caracterizou como pesquisa bibliográfica, de campo, por meio de verificações “in loco”, com o auxilio de um binóculo 8x40mm, registros sonoros e fotográficos, filmagens e fichas de observação, sobre a ave pesquisada e o local onde esta foi localizada. A identificação sonora de cada ave foi efetuada por meio da comparação do site wikiaves. Após a análise dos dados, constatou-se que 87 espécies de aves frequentam a referida propriedade, 57 espécies são restritas ao ambiente de mata nativa, entre estas: Penelope obscura, Sicalis flaveola, Hemithraupis guira, Cacicus chrysopterus, Saltator similis e Geothlypis aequinoctialis e 30 espécies de aves frequentam reflorestamento comercial, como Dendrocolaptes platyrostris, Cyanocorax chrysops e Turdus rufiventris, grande parte registrada em reflorestamento de pinus e uma pequena parte em reflorestamento de eucalipto. Também foram constatadas espécies migratórias que estiveram em reflorestamento de pinus e eucalipto como Patagioenas picazuro e espécies ameaçadas de extinção como Amazona vinacea que frequentaram a propriedade particular durante a realização da pesquisa. O estudo da avifauna realizado nesta pesquisa foi de extrema importância para a pesquisadora, com relação a sua formação de bióloga, pois as aves refletem as condições de um ecossistema, dessa maneira, são relevantes técnicas de manejo adequadas para a preservação do meio ambiente, tendo como base a sustentabilidade ambiental.
Ocorrência de Fabaceae – Mimosoidea em APPs da faixa de domínio da rodovia BR-116, trecho Curitiba, PR a Capão Alto, SC
Authors: Malczewski Fabio Luiz , Fritsch Mário , Povaluk Maristela
Published: June 2024

Esta pesquisa teve por finalidade identificar as espécies de fabáceas mimosoideas que ocorrem na faixa de domínio de APPs da BR-116, no trecho Curitiba, PR a Capão Alto, SC. No Brasil, as fabáceas figuram entre as famílias de angiospermas mais abundantes e representativas da flora em todos os domínios fitogeográficos; sua grande ocorrência representa importância tanto ecológica, como econômica e ornamental. Representam quase 2.700 espécies classificadas em 210 gêneros. O trabalho foi embasado em pesquisa bibliográfica, de campo e laboratorial, consistindo em saídas a campo para averiguar a ocorrência de mimosoideas nas APPs e coleta de ramos férteis, levados ao herbário HMSC da UnC Mafra. A flora constituinte das APPs deve ser conhecida para que haja uma efetiva proteção aos remanescentes florestais das margens da rodovia no trecho. As fabáceas constituem-se como um importante elemento da flora regional na Floresta Ombrófila Mista. Foram observadas e coletadas mimosoideas em onze municípios do trecho. Doze espécies foram verificadas no estudo, englobadas em seis gêneros. Mimosa foi o gênero mais representativo com sete espécies, os demais gêneros apresentaram uma espécie cada: Calliandra selloi (Spreng.) J.F. Macbr., Enterolobium contortisiliquum (Vell.) Morong, Inga striata Benth., Mimosa dutrae Malme, M. monticola Dusén, M. per-dusenii Burkart, M. ramosissima Benth., M. regnellii Benth., M. scabrella Benth., M. sparsa Benth., Parapiptadenia rigida (Benth.) Brenan e Senegalia recurva (Benth.) Seigler & Ebinger. Todas as espécies são nativas e nenhuma corre risco de extinção.
Ability to Maintain and Improve Health and Socio-Demographic Correlates among Children in Albania
Authors: Muja Herion , Vasil Suela , Toçi Dorina , Clemens Timo , Brand Helmut , Burazeri Genc
Published: June 2024

Objective

Our aim was to assess the level and socio-demographic correlates of the ability to maintain health among children in Albania, a post-communist country in the Western Balkans.

Methods

A cross-sectional study was conducted in Albania in September 2022. The study population consisted of a nationwide representative sample of 7,831 schoolchildren (≈54% girls) aged 12–15 years. A structured self-administered and anonymous questionnaire inquired about the children’s attitudes toward health promotion (ability to maintain and improve health) and a range of key dimensions on knowledge and practices regarding healthcare services. Socio-demographic data were also collected. Binary logistic regression was used to assess the socio-demographic correlates of children’s ability to maintain health.

Results

Overall, about 71% of schoolchildren exhibited the best attitudes toward health promotion (ability to maintain and improve health). In the multivariable adjusted logistic regression models, poorer attitudes toward health promotion (ability to maintain and improve health) were significantly related to older age (OR=1.2, 95% CI=1.0–1.3), middle/low maternal education (OR=1.2, 95%CI=1.1–1.3), poor/very poor economic situation (OR=1.5, 95%CI=1.2–1.8), lack of appropriate knowledge about rights to healthcare (OR=1.3, 95% CI=1.1–1.5), lack of knowledge about obtaining healthcare services (OR=1.7, 95%CI=1.4–2.2), and lack of consultations/visits with health professionals excluding vaccinations (OR=1.2, 95%CI=1.1–1.4).

Conclusions

Almost 1/3rd of Albanian schoolchildren included in this study did not exhibit the best attitudes toward health promotion (ability to maintain and improve health). The best attitudes were related to a higher socioeconomic level and adequate knowledge and practices regarding healthcare services. There is thus a need to increase health literacy levels among children in order to ultimately induce sustainable healthy behavioural/lifestyle practices.
Phytochemical Screening and Acute Toxicity Test of Caulerpa lentillifera J. Agardh Infusion Extract on Mice (Mus musculus L.)
Authors: Adiyanti Sekar , Phabiola Trisna Agung , Sutari Ni Wayan Sri
Published: June 2024

Caulerpa lentillifera has ingredients that are beneficial for health, such as anti-cancer, antioxidant, anti-diabetic, and immunostimulatory effects. This study was aimed to determine the content of phytochemical compounds and the LD50 acute toxicity dose of C. lentillifera infusion extracts on mice for their utilization as food or medicine. The phytochemical screening was done with a qualitative method. Twenty-five mice have been used for the acute toxicity test and divided into five groups of treatment (Control; 375 mg/kg BW; 750 mg/kg BW; 1.500 mg/kg BW; 3.000 mg/kg BW C. lentillifera infusion extracts orally). Symptoms of toxicity and mortality were observed 24 hours after treatment, and body weight was observed for seven days. The phytochemical screening result showed that the C. lentillifera infusion extracts contained alkaloids, saponins, and tannins. Acute toxicity tests showed no mortality in all treatment groups. Thus, the LD50 value could not be obtained and was classified as non-toxic.
ANTIFUNGAL ACTIVITY OF SIAM CITRUS (Citrus nobilis L.) ESSENTIAL OIL AGAINTS Lasiodiplodia theobromae THE PATHOGEN OF BLENDOK DISEASE
Authors: Pranata Kadek Dwipayana , Wirawan I Gede Putu , Wibawa I Putu Agus Hendra , Suada I Ketut , Wijaya I Nyoman , Phabiola Trisna Agung
Published: June 2024

Siam citrus (C. nobilis L.) is a type of citrus that is most widely cultivated in Bangli Regency. The main disease that attacks citrus plants is blendok caused by the fungus L. theobromae. Based on research siam citrus peel contains essensial oils that have potential as antifungals. The aim of this study was to study chemical content of essensial oil from siam citrus peel and its activity as an antifungal againts L. theobromae. Essensial oil was destilled using hydro steam distillition and analyzed by means of GC-MS. Antifungal activiy testing was carried out using the agar-well diffusion method with concentrations of 1%, 10%, 25%, 50%, 75%, and 100%. Dithane M45 6 g/l and DMSO 10% were used as positive and negative controls. The results showed that the siam citrus peel from Kintamani, Bangli contains essensial oils with the main chemical components, i.e. D-limonene (57.26%), Beta-pinene (9.09%), and Beta-myrcene (4.03%) which has uses as an antifungal, additive, antitumor, asthma and allergy reliever, repellent, anti-inflammatory, antioxidant, anticancer, and antibacterial. Essential oil concentration of 25 to 100% can inhibit the growth of L. theobromae. The largest diameter of inhibition is shown at a concentration of 100% and the smallest diameter of inhibition is shown at a concentration of 25%.
Keywords: C. nobilis L., essensial oils, GC-MS, L. Theobromae, antifungal
Fungsi dan Makna Mantunu Tedong dalam Upacara Rambu Solo’ pada Masyarakat Desa Salu Baruppu’, Toraja Utara
Authors: Petrus Riswan , Kumbara A.A.N. Anom , Aliffiati .
Published: June 2024

The Toraja people have a death ceremony which is usually called the rambu solo’. In carrying out the rambu solo’ ceremony, there is a process of buffalo sacrifice which is commonly called mantunu tedong. But now mantunu tedong have changed its meaning where formerly the tedong/buffalo that was sacrificed would be used as a vehicle and provision for the deceased to get to the spirit realm but now its become a place to show off wealth. This study aims to determine the function and meaning of mantunu tedong in rambu solo’ ceremony for the people of Salu Baruppu Village, North Toraja. This study uses qualitative methods, using interpretive theory and religious functions. Mantunu tedong for the people of Salu Baruppu Village, North Toraja has several functions, namely as a symbol of wealth and one's position in society and as a benchmark in carrying out the rambu solo’ ceremony, as well as strengthening kinship relations in society. Mantunu tedong is interpreted as a form of gratitude and final respect for those who have died.
Social Benefits Through Non-Parametric Contingent Valuation in invierte.pe. Case of Drinking Water Project in Peru
Authors: Rodriguez-Limachi Omar Moises , Incacutipa-Limachi Duverly Joao , Ticona-Carrizales Lucio , Avila-Choque Ronald Paul , Mamani-Sonco Vladimir Ylich Felipe , Velasquez-Sagua Hector Luciano , Puma-Llanqui Javier Santos
Published: June 2024

Objective: The objective of the research is to estimate the social benefits through the non-parametric contingent valuation model in the framework of the National System of Multiannual Programming and Investment Management (Invierte.pe), for a project to improve the drinking water service in the city of Ilave - Peru.
 
Method: The methodology used was the non-parametric contingent valuation technique through the Kriström model; by collecting information through structured surveys to project beneficiaries on whether they are willing or not willing to pay for the improvement of drinking water service; taking into account that currently the national system of Peru Invierte.pe uses a different model to estimate the social benefits through the calculation for the release of resources and the benefits for increased consumption of drinking water.
 
Results: The results found show a willingness to pay through the non-parametric model of 4.58 Soles, and updated social benefits for the entire evaluation horizon of the project of 3,518,927.17 Soles.
 
Conclusions: Finally, it is concluded that it is possible to incorporate the nonparametric contingent valuation model in the monetization of the social benefits of drinking water projects within the administrative system of the Peruvian government Invierte.pe.
Nonparametric Tests for Potability of Damodar River from Small Sample
Authors: Das Nilabhra Rohan
Published: June 2024

TThe Damodar River, originating from Jharkhand and flowing through West Bengal, is essential for the survival of the surrounding biosphere community and the population living along its banks, which includes people from different cultural and ethnic backgrounds. The government and non-governmental organizations have been working to improve the quality of the river, with the Damodar Valley Corporation instrumental in addressing the natural flow of the river and its tributaries.Biochemical Oxygen Demand (BOD) is used to indicate the organic quality of water, and the BOD values measured at regular intervals along the course of the river reveal a persistently high level of pollution, mainly caused by untreated chemical effluent dumping by multiple industrial companies located along the river.
Exploring the impact of mobile devices in electronics e-learning: A case study evaluating the effectiveness of mobile learning applications in the field of electronics and sensors
Authors: Ghoulam Khalid , Bouikhalene Belaid , Babori Abdelghani , Falih Noureddine
Published: June 2024

Integrating mobile devices into educational environments has revolutionised e-learning, presenting new opportunities and challenges. This research paper aims to examine the pivotal role of mobile devices in the e-learning environment and assess the effectiveness of mobile learning applications in enhancing the educational experience. The study employs a mixed-methods approach, combining quantitative data through surveys and usage analytics with qualitative insights from interviews and focus group discussions. By analysing the perspectives of both educators and learners, the research investigates how mobile devices contribute to the flexibility and accessibility of e-learning content. Additionally, the paper evaluates the effectiveness of various mobile learning applications in promoting engagement, knowledge retention, and overall learning outcomes. It scrutinises the features that contribute to the success of these applications, such as user interface design, interactivity, and adaptability to diverse learning styles. Furthermore, the research delves into the challenges of mobile learning, including device compatibility, connectivity, and user motivation issues. Strategies to overcome these challenges and optimise the benefits of mobile learning are explored. The findings of this study are expected to provide valuable insights for educators, curriculum designers, and developers of mobile learning applications. The research aims to contribute to the ongoing discourse on the effective integration of mobile devices in e-learning environments and offer recommendations for optimising the design and implementation of mobile learning strategies. Ultimately, this exploration seeks to foster a deeper understanding of the potential of mobile devices in shaping the future of education.
Inmersión submarina: Opiano, Halieutica 5.519-588 y cómo empatizar con los peces
Authors:   CONICET (Argentina), Abritta Alejandro
Published: June 2024

In Halieutica 5.519-588, Oppian of Cilicia explains the procedure of the capture of dolphins by Thracian fishermen, which concludes with the sacrifice of the female dolphin after the death of her calf. This procedure is also recounted by Elianus (1.17 = 1.18 Hercher), in a sequence whose similarity almost guarantees that he was drawing inspiration from the Cilician passage, or that both rely on a common source with the same account. The two authors offer a clear balance of perspectives, focusing their narratives at times on the fishermen and at times on the dolphin; it is evident, however, that the narrative strategy is very different in each. The aim of this paper is to show the resources that Oppian uses not only to arouse pity for the hunted dolphin and its sacrificed mother, but also to generate the immersion of the spectators in the story through identification with its victim.
El banquete imperial: Gastropolítica y universalismo en la Atenas clásica
Authors:   Universidad Nacional Autónoma de México (México), Olivera Diego Alexander
Published: June 2024

Inrecentyears,Historiography has reassessedthe aspirationfor universaldominationexpressed by Hellenistic rulers. It emphasizes on a marked influence of the predecessor kingdoms of theNearEast in the configuration of an idea of imperial universalism.However,ClassicalAthens was not immune to such particularity of ancient empires, that is, the claim to dominate the world. Hence, this article aims to look into Athenian universalism by connecting naval hegemony with the ability to manage access to food produced on the periphery of the Greek world. The main goal is to prove that even though Athens did not literally seek to dominate the world, it was eager to present itself as the center of the Earth, being capable of shipping products from all over the world to the Piraeus.
Lo posthumano en la era del Antropoceno. Transhumanismo, hibridación y agencia no-humana en la trilogía Arrebato, de Enki Bilal
Authors:   Universitat de València (España), López Fernández Daniel
Published: June 2024

In Enki Bilal’s graphic novel trilogy Coup de sang (2009-2015), the Francophone author depicts the Earth’s decision, after centuries of suffering anthropogenic environmental damage, to transform into a hostile space for humans. This phenomenon, as will be demonstrated, is related to contemporary discourses surrounding non-human agency in the Anthropocene era. In the post-apocalyptic environment in which Animal’z (2009), Julia & Roem (2011), and La Couleur de l’air (2014) take place, characteristic of the imagination of the Anthropocene and the climate fiction genre, the few survivors have adopted a hybrid human-animal mode of existence in their desperate attempt to survive. This raises issues of current relevance within the framework of post-humanist and post-anthropocentric philosophical currents by blurring the existing boundaries between the human and the non-human, while also referring to the possibilities and dangers of transhumanist technology.
Bambalinas, ondas y transistores: construcción del canon literario áureo durante el primer franquismo a través del radioteatro de Radio Nacional de España (1939-1959)
Authors:   Universidad de Sevilla (España), Márquez Martínez Esther , Pérez Martínez José Emilio ,   Universidad Complutense de Madrid (España)
Published: June 2024

Since its origins as a mass media, radio has been one of the fundamental institutions for the maintenance of social order. During the Franco dictatorship, it played an important role, as an ideological apparatus, in the ideological production and reproduction of the regime. T herefore, the study of the contents of its programs helps us reveal how the dictatorship tried to legitimize certain values and discourses to implant a dominant common sense. The aim of this article is to analyze the image projected by Radio Nacional de España during the first Franco regime (1939-1959) of the Hispanic literary canon of the 16th and 17th centuries, that of a supposed glorious past, product of a partisan interpretation of history and culture, vindicated by the dictatorship.
Tratamiento lexicográfico de las palabras de origen español en el chino: compilación actual y sus problemas
Authors:   Universitat Autònoma de Barcelona (España), Nie Lingzhi
Published: June 2024

Foreign terms in modern Chinese are currently more influenced by Japanese and English, which is why the words of Spanish origin in Chinese have been little studied. This article systematically compiles and classifies words of Spanish origin in Chinese based on the data from the Hanyu Wailaici Cidian (汉语外来词词典) [Dictionary of Chinese Foreign Terms] (Cen, 1990) and the Xinhua Wailaiyu Cidian (新华外来词词典) [Xinhua Dictionary of Foreign Terms] (Shi, 2019), with the main purpose of analyzing their characteristics and their current compilation. Most entries were found to be nouns, and a more restricted vocabulary is observed in areas such as science and economics. Moreover, among the different types of calques and borrowings, the prevailing ones for Spanish words introduced into Chinese are partially assimilated borrowings and blended derivative borrowings.
Bacterial etiology in cell phones of health personnel from a clinic in Chiclayo
Authors:   Facultad de Ciencias Biológicas, Universidad Nacional Pedro Ruíz Gallo. Lambayeque, Perú, De la Cruz Cueva Alexander Alexis , Gonzales Velásquez Grescia Azucena , Ventura Flores Roberto ,   Laboratorio de Investigación, Hospital Regional Lambayeque. Chiclayo, Perú,   Bachiller en Biología,   Biólogo. Maestro en Microbiología Clínica
Published: June 2024

The study aimed to describe the etiology and bacterial frequency on the cell phones of healthcare personnel at the Hospital de Clínicas de Chiclayo, Peru, from March to August 2022. Thirty phones from doctors, nurses, and technicians in hospitalization areas and the Intensive Vigilance Unit (IVU) were analyzed. Samples were taken from the phone screens, cultured, and bacteria were identified using biochemical tests. The data was recorded and analyzed with Microsoft Excel 2013. Bacterial colonization was found on 56.7% of the phones: Gram-positive bacteria on 33.3% and Gram-negative bacteria on 23.3%. Staphylococcus coagulase-negative (35.3%) and Escherichia coli (23.5%) predominated in hospitalization, while Staphylococcus aureus (23.5%) predominated in the IVU. 66.7% of the personnel rarely disinfected their phones, and 40% washed their hands infrequently. Staphylococcus coagulase-negative, S. aureus, and E. coli were the most frequent agents, suggesting deficiencies in hospital hygiene practices.
Hypertriglyceridemia associated with insulin resistance in children with obesity
Authors:   Universidad Privada Antenor Orrego. Trujillo, Perú, Cacha Villacorta Rosario Patricia , Salcedo Espejo Elena , Saavedra Camacho Johnny Leandro , Iglesias Osores Sebastian ,   Facultad de Ciencias Biológicas, Universidad Nacional Pedro Ruiz Gallo. Lambayeque, Perú.,   Médica cirujana,   Pediatra,   Biólogo Microbiólogo,   Biólogo
Published: June 2024

Introduction: Hypertriglyceridemia has been linked to insulin resistance. Objectives: To evaluate the relationship and predictive capacity of hypertriglyceridemia for insulin resistance in obese children. Methods: A cross-sectional analytical study was conducted in obese children aged 6 to 14 years, treated at the Belén Hospital of Trujillo between 2014 and 2019. Fifty-eight randomly selected medical records were analyzed. Insulin resistance was measured using the Homeostasis Model Assessment (HOMA) index (≥3). Descriptive, correlational analyses, and Odds Ratio (OR) calculations were used, along with predictive indicators such as sensitivity and specificity. Results: Of the 58 children studied, 58.6% had elevated triglyceride levels and 74.1% showed insulin resistance. There was a significant correlation between triglyceride levels and the HOMA index (coef.: 0.543; p<0.001). Elevated triglyceride levels (OR=18.91; 95% CI: 3.67-97.36; p<0.001), fasting glucose (OR=46.20; 95% CI: 5.39-396.06; p=0.010), fasting insulin (OR=52.89; 95% CI: 6.11-457.55; p<0.001), and the presence of acanthosis nigricans (OR=36.17; 95% CI: 4.28-305.98; p<0.001) were significantly associated with insulin resistance. Hypertriglyceridemia showed a sensitivity of 74.4% and a specificity of 86.7% for predicting insulin resistance. Conclusion: Hypertriglyceridemia is significantly associated with insulin resistance in obese children and has an acceptable performance as a predictor. This factor may serve as an early marker and predictor to implement appropriate preventive measures in vulnerable populations.
Why are You Late? A Descriptive Study of Delay in Treatment Seeking among Patients of Carcinoma Breast Presenting to a Tertiary Care Hospital in South India
Authors: Patta Manoj Kumar , Shankar Gomathi , Ahmed Furqan Mohammed
Published: June 2024

Objectives:

The objectives of this study were as follows: Primary: To estimate the proportion of breast cancer patients with delay in presentation. Secondary: To assess the reasons for delay in presentation among patients with breast cancer. To identify the sociodemographic and clinical characteristics associated with delayed presentation among patients with breast cancer.

Materials and Methods:

We conducted a hospital-based descriptive study at a tertiary care hospital- Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), from a period of January 2016 to June 2016. The participants were interviewed at the time of their hospital visit with a standardised questionnaire after obtaining informed consent. The patients were asked to recall the time interval between the first recognition of symptoms and the first medical consultation. A duration of >3 months was considered a patient delay. The patient reported the first symptom, and the symptoms at presentation were noted. Through clinical examination of the breasts, axilla and other systems was performed, and the positive clinical features were recorded.

Results:

A total of 126 women were included in the study. Out of 126 patients, 37 patients (29.4%) presented to healthcare personnel within 3 months of identifying their symptoms, and 89 patients (70.6%) presented later than 3 months. The mean duration of delay is 171.5 days, with a standard deviation of 229.45 and a median delay being 120 days. The most common cause for delay was due to the patient’s perception that the lump was harmless or temporary. The average time taken by the patients to present to JIPMER for definitive management of breast cancer after visiting a local physician was a median of 25 days and a mean of 48.77 days. The time taken for confirmation of diagnosis from the time of presentation to JIPMER was a median duration of 13 days and a mean duration of 16.58 days with a standard deviation of 12.31. About 90% of the patients had their diagnosis confirmed within 1 month.

Conclusion:

In our study, the proportion of delayed presentation among breast cancer patients was found to be 70.6%. Patients from rural areas and with lower educational status were found to have a higher incidence of delayed presentation. Lack of awareness of breast cancer symptoms and their misinterpretation as harmless, temporary and benign are the main reasons for delayed presentation. Patients who practised breast self-examination presented earlier. Further studies with a larger sample will help in identifying the other sociodemographic and clinical characteristics responsible for delayed presentation.
Analysis of variants of non-adiabatic ring polymer molecular dynamics for calculating excited state dynamics
Authors: Cao Ziying , Kretchmer Joshua
Published: June 2024

The non-adiabatic ring polymer molecular dynamics (NRPMD) method, which combines the path-integral ring polymer molecular dynamics framework for the nuclei with the Meyer-Miller-Stock-Thoss mapping of the electronic states, is a powerful tool for simulating non-adiabatic dynamics including nuclear quantum effects. However, challenges arise in utilizing NRPMD associated with zero-point energy leakage between the electronic and nuclear degrees of freedom and ambiguities in how to apply the method under non-equilibrium conditions. Here, we explore several variants of NRPMD and compare their performance using a set of benchmark systems for excited-state electronic population dynamics. Within this context, we adopt an idea from recent work on the linearized semi-classical initial value representation and derive a new NRPMD correlation function for the population of the electronic states in terms of a trace-less operator and the identity operator. The in-depth analysis of the different choices when utilizing NRPMD provides new insight into the practical implementation of the method and related techniques.
DNA-based AND logic gate as a molecular precision tool: selective recognition of protein pairs in lipid nanodiscs and subsequent binding of gold nanorods
Authors: De Sayantan , Hechler Michelle , Cheng Mingpan , Giesler Helene , Brandau Sven , Saccà Barbara , Schlücker Sebastian
Published: June 2024

The specificity of target recognition is paramount in fields such as cellular biology, diagnostics, and therapy. Traditional antibody-based methods focus on recognizing single antigens; however, the next level of specificity involves targeting pairs of antigens simultaneously. This study introduces a DNA-based molecular logic AND gate designed to recognize the two membrane proteins PD-L1 and CD3 as antigens via the corresponding antibody-oligonucleotide conjugates. The two membrane proteins are embedded in lipid nanodiscs that serve as a model system for cell membranes. By utilizing antibody-oligonucleotide conjugates as input signals, the DNA logic gate operates sequentially, becoming fully activated only upon binding both target proteins. The output signal facilitates subsequent actions, such as target isolation via magnetic bead extraction and functionalization with DNA-tagged gold nanorods for potential photothermal therapy. Our proof of concept for a molecular precision tool that processes two input signals in an AND operation and converts them to an output signal offers new avenues for high-specificity diagnostics and therapeutic interventions.
Chemoproteomic identification of a phosphohistidine acceptor: Insights into posttranslational regulation of glycolysis
Authors: Choi Solbee , Ahn Seungmin , Cho Kyung Hyun , Lee Sung Kuk , Kee Jung-Min
Published: June 2024

Histidine phosphorylation is an underexplored form of protein phosphorylation. Despite the widespread existence of phosphohistidine (pHis) sites, particularly in bacteria, their phosphorylation regulation and physiological functions remain poorly understood. In this study, we developed a chemoproteomic strategy employing a stable pHis analog to identify pHis-recognizing proteins in Escherichia coli. Our probe successfully labeled known pHis-recognizers and revealed many putative pHis acceptors, including phosphofructokinase-1 (PfkA), a key glycolytic enzyme. We demonstrated that PfkA undergoes histidine phosphorylation at His249 mediated by the phosphocarrier protein PtsH, thereby reducing enzyme activity. This phosphorylation was reversed by the pHis-specific phosphatase SixA, which restored the PfkA activity. Our findings reveal a novel posttranslational regulatory mechanism affecting glycolysis, implicating a broader role of histidine phosphorylation in bacterial metabolic control.
Comprehensive Screening of Conditions for Block Copolymer Nanoaggregate Formation via Automated DLS
Authors: Weerarathna Lakshani , Weismantel Oliver , Junkers Tanja
Published: June 2024

A fully automated robotic synthesizer for the screening of amphiphilic block copolymer nanoparticle synthesis is presented. To reach this aim, block copolymer solutions are mixed in continuous flow with water, allowing for the automated variation of overall polymer concentration, mixing ratio of the water and organic solvent phase and the overall flow rate of the system. Particle sizes are monitored online via a commercial DLS instrument, and the obtained data is automatically analyzed. While the machine generally allows to produce particles with a 10% standard deviation, the control software performs automatic outlier detection based on measurement of data in triplicates, and repeats experiments until a statistically robust result is obtained. The synthesis platform was tested on 5 individual block copolymers, namely poly(ethyl methacrylate)-block-poly(2-(dimethylamino)ethyl acrylate) (PEMA75-b-PDMAEA50), polystyrene-block-poly(2-(dimethylamino)ethyl acrylate) (PS50-b-PDMAEA25), polystyrene-block-poly(poly(ethylene glycol) methyl ether acrylate) (PS40-b-PPEGMEA35, PS90-b-PPEGMEA23) and polystyrene-block-poly(2-hydroxy ethyl acrylate) (PS90-b-PHEA14), which were obtained from RAFT polymerization.
NOTAS SOBRE O MÉTODO COMO DESVIO EM WALTER BENJAMIN
Authors: Ehlke da Silva Jessica
Published: June 2024

A partir do Prólogo de Origem do drama trágico alemão, intenta-se abordar a teoria crítico-epistemológica de Walter Benjamin sob o enfoque dado pelo autor aos problemas que defluem do método more geometrico, que se põe como propedêutica à investigação dos objetos filosóficos. Ao recorrer à lógica e à matemática, e não à linguagem que codifica historicamente a filosofia, tal metodologia se apresenta como condição universal para o conhecimento claro e distinto, conquanto se revele, ao mesmo tempo, gesto de renúncia à verdade, seja por pretendê-la capturável em uma rede conceitual prévia, seja por tomá-la como mero produto de uma equação. Benjamin, diante desse impasse, evoca a forma do tratado escolástico-medieval como modo de exposição filosófica assaz a fazer justiça aos objetos em sua conformação inarredavelmente plurívoca. Pela forma expositiva do tratado, os objetos são cotejados em relação ao todo em que se inscrevem, assim como o todo é remetido aos objetos, em um movimento dialético do qual, segundo ele, se faz possível a exsurgência ou o lampejar de seu teor de verdade. No projeto benjaminiano, portanto, evidencia-se a aliança entre o pensamento filosófico e seu modo de exposição mediante a concepção de método enquanto desvio ou caminho indireto (Umweg), e que pode ser compreendido como um exercício contemplativo de idas, vindas e pausas reflexivas sobre os fenômenos e as questões que emergem de sua singularidade.
NIETZSECHE, NÊGO BISPO E O DESPREZO DO REAL (CORPO/NATUREZA) NA COSMOLOGIA CRISTÃ
Authors: Deus Flávio Rocha de
Published: June 2024

Neste ensaio são discorridos tópicos para formulação de uma breve crítica a duas concepções da cosmologia euro-cristã: a negação do corpo e a deidade transcendente inacessível para apontar a relação de tais pontos a um discurso mais central da religião: a negação deste mundo em prol de uma realidade metafísica desconhecida e inacessível pelos sentidos. Nietzsche e Antônio Bispo dos Santos (Nêgo Bispo) nos auxiliam na reflexão de tal tema, o filósofo alemão suas fornece suas considerações acerca dos Desprezadores do corpo, a fábula do mundo verdadeiro e sua crítica ao platonismo puro e do povo, já o pensador quilombola brasileiro nos fornece com suas considerações sobre a biointeratividade com os deuses territorializados, explicando porque culturas de deuses imanentes costumam ter uma relação de maior respeito com o meio ambiente.
ABRA A FELICIDADE
Authors: Dias Bauce Paola
Published: June 2024

O presente ensaio visa traçar o histórico da transnacional Coca-Cola e sua crescente consolidação dentro do desenvolvimento do capitalismo, analisando as estratégias de marketing feitas pelas propagandas da marca e evidenciando a forma como esta propicia um ideário em volta de seu produto. É possível perceber como o papel da propaganda foi essencial para a construção da imagem da Coca-Cola, pois apesar dos escândalos ambientais, empreitadas contra o setor de saúde pública e manipulação de artigos científicos que pudessem prejudicá-la, a marca continua sendo uma das mais valiosas do mercado mundial e uma das mais consumidas. Para explicarmos tal fenômeno, abordamos o conceito de capitalismo artista de Lipovetsky e Serroy (2005) e a libertação pelo consumo apontado por Boltanski e Chiapello (2009), clarificando que o real produto vendido pela Coca-Cola vai além de um simples refrigerante.
HISTÓRIA DA FILOSOFIA E FILOSOFIA, TEMAS E PERCURSOS
Authors: Frizzarin de Souza Gabriel , Ferreira Oliveira Eliakim , Ordonhes Adriano Ribeiro Ramon
Published: June 2024

O artigo tem por objetivo extrair a concepção didática do livro Filosofia: temas e percursos de modo a mostrar uma abordagem do ensino de filosofia que privilegie a história da filosofia não como centro, mas como referencial de ensino. Ao fim, o artigo discute os limites e vantagens dessa abordagem.
DELEUZE E GUATTARI
Authors: Julio João Victor
Published: June 2024

A partir dos escritos de Gilles Deleuze (1925 – 1995) e Félix Guattari (1930 – 1992), entou-se apresentar alguns deslocamentos entre a filosofia or eles proposta de maneira a pensarmos acerca de algumas práticas escolares. Antes mesmo da escolha destes autores, partiu-se da hipótese inicial de que houvesse, talvez um certo excesso de conhecimentos científicos no currículo em detrimento das artes e filosofias. Deste modo, buscou-se nestes autores uma base para enriquecer ainda mais nossa compreensão e tal qual, ampliarmos as discussões conceituais acerca das ciências, artes e filosofias. Através destes autores, percebeu-se que tais saberes em sua dimensão menor possuem caráter próprio e criador, coexistindo para fora de hierarquias. Com isto, acreditamos na possibilidade de conteúdos curriculares criadores que possam ensejar a produção contínua destas dimensões do pensamento e integrá-las ainda mais à atualidade. Para melhor explorar estas dimensões, tentou-se deslocar o conceito de rizoma e as múltiplas perspectivas que o envolvem, de maneira a rizomatizar, não apenas as ciências no currículo, mas em igual medida, as artes e as filosofias.
ESCRITA E CONSTRUÇÃO DE SI
Authors: Oliveira Priscila
Published: June 2024

O presente artigo busca esboçar alguns elementos que constituem o processo de formação da pessoa-escritora Carolina Maria de Jesus, para além da obra “Quarto de Despejo”, em contraste a um suposto estranhamento em relação a identificação com uma comunidade, ou sentimento de pertença, da pessoa-escritora “mulher, negra e periférica”. Para tanto, busca-se pontuar determinados aspectos biográficos da autora, bem como contextualizar o ambiente de sua produção, considerando o cenário sociopolítico brasileiro, em especial da metrópole paulistana de meados do século XX, procurando não sobrepor tais aspectos ao caráter estético-literário presente no conjunto de sua obra. Conclui-se dessa trajetória que para alcançar a potência criativa da narrativa e compreender como se deu a formação da pessoa-escritora Carolina Maria de Jesus, faz-se necessário articular tanto a perspectiva dos estudos decoloniais, como a crítica que se forja no solo comum das vivências práticas dos sujeitos ditos marginalizados, seja pelo recorte de classe, como de raça e gênero.
PASOLINI – O FANTASMA DA ORIGEM
Authors: Alves Teixeira Michelly
Published: June 2024

Recentemente, saiu pela Editora Âyiné, um livrinho curto que, entre pequenos ensaios, reflete teses pasolinianas de maneira tal que sua estrutura de setenta e seis páginas, prepara o leitor para o vasto campo de possibilidades da obra de Pasolini. Seu título, impenetrável a princípio, Pasolini – o fantasma da Origem, também é parte de um ensaio pertencente ao livro. Seu autor, Massimo Recalcati, psicanalista e escritor italiano, famoso por adentrar a contemporaneidade mediante um olhar psicanalítico, dispõe uma linha narrativa entre um ensaio e outro, não escapando totalmente da singularidade intricada de que possui a narrativa pasoliniana, mas facilitando e muito o acesso com uma escrita linear.
CONSIDERAÇÕES SOBRE A ESTÉTICA
Authors: Chartier Émile , Gomes Macedo Caio
Published: June 2024

Em 1923, a Livraria Stock publicou, em uma coleção de pequeno formato Les Contemporains, uma série de Propos sur l'Esthétique escritos durante os anos de 1921-1923 e extratos dos Libres Propos (Journal d'Alain). O monumental Sistema de Belas Artes composto por Alain através dos ensaios da guerra, acabava de ser publicado (1920) nas Edições da Nouvelle Revue Française. Em oposição ao Sistema, e por consequência introduzindo-a, esta pequena coleção de 35 Propos, reunidas quase ao acaso teve a virtude fulgurante de revelar aos leitores mais diversos uma grande e nova Présence. A tradução foi realizada por colegas em colaboração com o Grupo de Tradução do Departamento de Filosofia da Universidade de Brasília. A proposta é a de traduzir regularmente obras de filosofia ainda inéditas em língua portuguesa e disponibilizá-las em periódicos de acesso livre.
Development of web-based application for crime reporting and handling in Malawi police service
Authors: Fabiano Nyirenda , Chipatso Medi
Published: June 2024

Paper-based systems for handling crime reporting have become one of the most challenging methods in police services globally. The Malawi Police Service (MPS) uses this system for handling crime reporting. This system presents a number of challenges, such as delay in disseminating crime reports by victims or witnesses, misplacement or loss of crime-recorded files from the police shelves, and inconsistency of suspect documentation due to wrong manipulation or alteration by some individuals in the police offices. This paper focuses on the development of a web-based application for enhancing crime reporting and investigation in the police service. The police service needs to emphasize effective utilization of crime reporting factors to mitigate and reduce the risk of losing evidence. An assigned officer will be needed to supervise the use of the application to be implemented in the police service to make sure it is used for the right purpose. The application will be implemented using PHP, HTML, and Javascript programming languages and a database system using the MYSQL programming language.
Implementation of a virtuous incubation system utilizing IoT technology
Authors: Precious Chilupsya , Joel Mulepa
Published: June 2024

The Virtuous Incubation System is a solution aimed at transforming poultry farming by integrating Internet of Things (IoT) technology into the incubation process. This paper seeks to improve the efficiency and success rate of poultry egg incubation while minimizing manual intervention, reducing resource consumption, and ensuring optimal conditions for embryo development by providing a smart incubator system. The smart incubator addresses the challenges of traditional manual monitoring and adjustments by leveraging IoT devices, sensors, and data analytics to create an automated and intelligent incubation system. It provides energy efficiency by incorporating energy-efficient components to minimize power consumption, thereby reducing operational costs for farmers, and by providing notifications and alerts where critical deviations in environmental conditions or equipment malfunction, enabling proactive intervention to prevent losses. A cross-section of small- to medium-scale poultry producers, particularly those engaged in hatching chicks, were interviewed to highlight the main challenges regarding the business of hatching chicks. It was learned through the interviews that chick production on a small to medium scale was relatively expensive due to the labor employed to monitor the production and losses due to adverse conditions resulting in a poor success rate in hatching the chicks. Thus, the implementation of the virtuous incubation system comes in to solve the main challenges being faced by the local poultry producers.