bluuebunny/crossref_metadata_2025 huggingface dataset:
The Sequence and a Three-Dimensional Structural Analysis Reveal Substrate Specificity among Snake Venom Phosphodiesterases
Authors: Ullah Anwar , Ullah Kifayat , Ali Hamid , Betzel Christian , ur Rehman Shafiq
Published: October 2019

(1) Background. Snake venom phosphodiesterases (SVPDEs) are among the least studied venom enzymes. In envenomation, they display various pathological effects, including induction of hypotension, inhibition of platelet aggregation, edema, and paralysis. Until now, there have been no 3D structural studies of these enzymes, thereby preventing structure–function analysis. To enable such investigations, the present work describes the model-based structural and functional characterization of a phosphodiesterase from Crotalus adamanteus venom, named PDE_Ca. (2) Methods. The PDE_Ca structure model was produced and validated using various software (model building: I-TESSER, MODELLER 9v19, Swiss-Model, and validation tools: PROCHECK, ERRAT, Molecular Dynamic Simulation, and Verif3D). (3) Results. The proposed model of the enzyme indicates that the 3D structure of PDE_Ca comprises four domains, a somatomedin B domain, a somatomedin B-like domain, an ectonucleotide pyrophosphatase domain, and a DNA/RNA non-specific domain. Sequence and structural analyses suggest that differences in length and composition among homologous snake venom sequences may account for their differences in substrate specificity. Other properties that may influence substrate specificity are the average volume and depth of the active site cavity. (4) Conclusion. Sequence comparisons indicate that SVPDEs exhibit high sequence identity but comparatively low identity with mammalian and bacterial PDEs.
Evolution of a Landscape Phage Library in a Mouse Xenograft Model of Human Breast Cancer
Authors: Gillespie James W. , Yang Liping , De Plano Laura Maria , Stackhouse Murray A. , Petrenko Valery A.
Published: October 2019

Peptide-displayed phage libraries are billion-clone collections of diverse chimeric bacteriophage particles, decorated by genetically fused peptides built from a random combination of natural amino acids. Studying the molecular evolution of peptide-displayed libraries in mammalian model systems, using in vivo phage display techniques, can provide invaluable knowledge about the underlying physiology of the vasculature system, allow recognition of organ- and tissue-specific networks of protein–protein interactions, and provide ligands for targeted diagnostics and therapeutics. Recently, we discovered that landscape phage libraries, a specific type of multivalent peptide phage display library, expose on their surface comprehensive collections of elementary binding units (EBUs), which can form short linear motifs (SLiMs) that interact with functional domains of physiologically relevant proteins. Because of their unique structural and functional features, landscape phages can use an alternative mechanism of directed molecular evolution, i.e., combinatorial avidity selection. These discoveries fueled our interest in revisiting the in vivo evolution of phage displayed libraries using another format of display, i.e., landscape phages. In this study, we monitored the evolution of a landscape phage library in a mouse model with and without an implanted human breast cancer tumor xenograft. As expected, the multivalent architecture of landscape phage displayed proteins provided strong tissue selectivity and resulted in a huge diversity of tissue penetrating, chimeric phage particles. We identified several types of EBU interactions that evolved during the course of tissue distribution, which included interactions of EBUs with all tissue types, those EBUs that interacted selectively with specific organs or tissues with shared gene expression profiles or functionalities, and other EBUs that interacted in a tissue-selective manner. We demonstrated that landscape phage libraries are a rich collection of unique nanobioparticles that can be used to identify functional organ and tissue-binding elements after the evolution of a phage display library in vivo.
Moisture Sources for Precipitation and Hydrograph Components of the Sutri Dhaka Glacier Basin, Western Himalayas
Authors: Singh Ajit T. , Rahaman Waliur , Sharma Parmanand , Laluraj C. M. , Patel Lavkush K. , Pratap Bhanu , Gaddam Vinay Kumar , Thamban Meloth
Published: October 2019

Himalayan glaciers are the major source of fresh water supply to the Himalayan Rivers, which support the livelihoods of more than a billion people living in the downstream region. However, in the face of recent climate change, these glaciers might be vulnerable, and thereby become a serious threat to the future fresh water reserve. Therefore, special attention is required in terms of understanding moisture sources for precipitation over the Himalayan glaciers and the hydrograph components of streams and rivers flowing from the glacierized region. We have carried out a systematic study in one of the benchmark glaciers, “Sutri Dhaka” of the Chandra Basin, in the western Himalayas, to understand its hydrograph components, based on stable water isotopes (δ18O and δ2H) and field-based ablation measurements. Further, to decipher moisture sources for precipitation and its variability in the study region, we have studied stable water isotopes in precipitation samples (rain and snow), and performed a back-trajectory analysis of the air parcel that brings moisture to this region. Our results show that the moisture source for precipitation over the study region is mainly derived from the Mediterranean regions (>70%) by Western Disturbances (WDs) during winter (October–May) and a minor contribution (<20%) from the Indian Summer Monsoon (ISM) during summer season (June–September). A three-component hydrograph separation based on δ18O and d-excess provides estimates of ice (65 ± 14%), snowpack (15 ± 9%) and fresh snow (20 ± 5%) contributions, respectively. Our field-based specific ablation measurements show that ice and snow melt contributions are 80 ± 16% and 20 ± 4%, respectively. The differences in hydrograph component estimates are apparently due to an unaccounted snow contribution ‘missing component’ from the valley slopes in field-based ablation measurements, whereas the isotope-based hydrograph separation method accounts for all the components, and provides a basin integrated estimate. Therefore, we suggest that for similar types of basins where contributions of rainfall and groundwater are minimal, and glaciers are often inaccessible for frequent field measurements/observations, the stable isotope-based method could significantly add to our ability to decipher moisture sources and estimate hydrograph components.
Asymmetric Response of Land Storage to ENSO Phase and Duration
Authors: Chandanpurkar Hrishikesh A. , Fasullo John T. , Reager John T. , Nerem Robert S. , Famiglietti James S.
Published: October 2019

Emergence of global mean sea level (GMSL) from a ‘hiatus’ following a persistent La Niña highlights the need to understand the causes of interannual variability in GMSL. Several studies link interannual variability in GMSL to anomalous transport of water mass between land and ocean—and subsequent changes in water storage in these reservoirs—primarily driven by El Niño/Southern Oscillation (ENSO). Despite this, asymmetries in teleconnections between ENSO mode and land water storage have received less attention. We use historical simulations of natural climate variability to characterize asymmetries in the hydrological response to ENSO based on phase and duration. Findings indicate pronounced phase-specific and duration-specific asymmetries covering up to 93 and 50 million km2 land area, respectively. The asymmetries are seasonally dependent, and based on the mean regional climate are capable of influencing inherently bounded storage by pushing the storage-precipitation relationship towards nonlinearity. The nonlinearities are more pronounced in dry regions in the dry season, wet regions in the wet season, and during Year 2 of persistent ENSO events, limiting the magnitude of associated anomalies under persistent ENSO influence. The findings have implications for a range of stakeholders, including sea level researchers and water managers.
Influences of Plateau Zokor Burrowing on Soil Erosion and Nutrient Loss in Alpine Meadows in the Yellow River Source Zone of West China
Authors: Li Guorong , Li Xilai , Li Jinfang , Chen Wenting , Zhu Haili , Zhao Jianyun , Hu Xiasong
Published: October 2019

Plateau zokors (Eospalax baileyi) are an agent actively involved in causing soil erosion and meadow degradation in the Yellow River Source Zone of West China. This study aims to quantify the amount of soil and nutrient loss from zokor mounds in relation to slope gradient and rainfall intensity, and to assess the amount of soil loss in zokor-infested areas compared with healthy meadows in Henan County, Qinghai Province. The results showed that zokor mounds were gradually lowered at a rate of 1.8–3.9 cm h−1. Soil loss occurred two min after the rain began, reaching the maximum level during the first 20 min. The rate of soil loss and nutrient loss increased with the rainfall intensity and slope gradient. When the rainfall intensity rose from 5 to 10 mm h−1, and from 10 to 15 mm h−1, the total soil loss on 10° slopes increased by 2.5 times and 3.9 times, respectively, and soil nutrient loss increased by 1.7 times and 2.7 times, respectively. As the slope gradient steepened to 20°, the corresponding figures were 2.8 times and 4.3 times for total soil loss, and 1.8 times and 2.9 times, respectively, for soil nutrient loss. When the slope rose to 30°, the soil loss increased by 3.0 and 4.5 times, and the soil nutrient loss increased by 1.8 times and 3.1 times, respectively. There was a power function between soil loss and surface runoff (S = 0.2371Q2.2307, R2 = 0.9529). The soil was eroded at a rate of 256.6 g m−2 h−1 from zokor mounds, 17.7 times higher than in intact meadows, and 1.8 times higher than in partially recovered meadows. Most of the eroded soils had a mean diameter of 0–1.2 mm. It is recommended that artificial control of plateau zokors should be implemented, together with other ecological restoration measures to restrain the soil erosion problem caused by zokor activities.
Sustainable Water Use for International Agricultural Trade: The Case of Pakistan
Authors: Ali Tariq , Nadeem Abdul M. , Riaz Muhammad F. , Xie Wei
Published: October 2019

Sustainable use of resources is critical, not only for people but for the whole planet. This is especially so for freshwater, which in many ways determines the food security and long-term development of nations. Here, we use virtual water trade to analyze the sustainability of water used by Pakistan in the international trade of 15 major agricultural commodities between 1990 and 2016 and in 2030. Most of the existing country-level studies on virtual water trade focused on net virtual water importers, which are usually water-scarce countries as well. This is the first study to concentrate on a water-stressed net virtual water-exporting country. Our results show that Pakistan has been trading large and ever-increasing volumes of virtual water through agricultural commodities. Despite the overall small net export of total virtual water per year, Pakistan has been a net-exporter of large quantities of blue (fresh) virtual water through its trade, even by fetching a lower value for each unit of blue water exported. Given Pakistan’s looming water scarcity, exporting large volumes of blue virtual water may constrain the country’s food security and long-term economic development. Improving water use efficiency for the current export commodities, for example, rice and exploring less water-intensive commodities, for example, fruits and vegetables, for export purposes can help Pakistan achieve sustainable water use in the future.
Toward a New Generation of Two-Fluid Flow Models Based on the Thermodynamically-Constrained Averaging Theory
Authors: Bruning Kelsey , Miller Cass T.
Published: October 2019

Traditional models of two-fluid flow through porous media at the macroscale have existed for nearly a century. These phenomenological models are not firmly connected to the microscale; thermodynamic constraints are not enforced; empirical closure relations are well known to be hysteretic; fluid pressures are typically assumed to be in a local equilibrium state with fluid saturations; and important quantities such as interfacial and curvilinear geometric extents, tensions, and curvatures, known to be important from microscale studies, do not explicitly appear in traditional macroscale models. Despite these shortcomings, the traditional model for two-fluid flow in porous media has been extensively studied to develop efficient numerical approximation methods, experimental and surrogate measure parameterization approaches, and convenient pre- and post-processing environments; and they have been applied in a large number of applications from a variety of fields. The thermodynamically constrained averaging theory (TCAT) was developed to overcome the limitations associated with traditional approaches, and we consider here issues associated with the closure of this new generation of models. It has been shown that a hysteretic-free state equation exists based upon integral geometry that relates changes in volume fractions, capillary pressure, interfacial areas, and the Euler characteristic. We show an analysis of how this state equation can be parameterized with a relatively small amount of data. We also formulate a state equation for resistance coefficients that we show to be hysteretic free, unlike traditional relative permeability models. Lastly, we comment on the open issues remaining for this new generation of models.
Numerical and Laboratory Investigations of Closely-Spaced and Joint Infiltration of Precipitation and Treated Waste Water
Authors: Händel Falk , Fichtner Thomas , Graeber Peter-Wolfgang
Published: October 2019

The closely-spaced infiltration of treated waste water and precipitation water may have advantages when compared to the single infiltration, such as reduction of construction costs and space requirements. Recent numerical works showed the theoretical applicability of this approach. A physical tank experiment has been set-up to study the processes in more detail and provide real data on the water flow as well as the purification potential during infiltration. Various scenarios of treated waste water infiltration with and without precipitation events have been technically realized. These data have then been used to implement a numerical model that supported the review of criteria for a proof of the principal applicability. A joint infiltration set-up is proposed and analyzed after successful evaluation of the closely-spaced, but separated infiltration of treated waste water and precipitation water. Again, both the laboratory and numerical works show the principal applicability of the proposed technique.
The Parker Project: Cross-Brand Service Testing Using V2G
Authors: Bach Andersen Peter , Hashemi Seyedmostafa , Sousa Tiago , Meier Soerensen Thomas , Noel Lance , Christensen Bjoern
Published: October 2019

The Parker project sought to experimentally validate that contemporary series-produced electric vehicles (EVs), capable of V2G, are ready to participate in a number of advanced grid services. In such services, the timing, size and direction of power and energy exchanged between the EV battery and grid is controlled as to support either a single building, the local neighborhood or the regional power system. Vehicles purposely designed for such services are referred to as grid integrated electric vehicles (GIVs). The field of research, describing how GIVs may be used to actively support the power system, is called Vehicle–Grid Integration (VGI). The purpose of this paper is to present how the Danish Parker project has systematically categorized a range of grid services, collected in a service catalog, and then illustrate state-of-the-art EVs ability to support such services through experimental validation. Results are presented for three different tests performed in Parker; marginal emission factor charging, frequency containment reserves and a performance test for controlling power setpoints. The ultimate aim of this paper, and the Parker project, is to promote the GIV concept so that it may inform the design and capabilities of present and future EVs, EV supply equipment (EVSE) and communication standards.
Indicators of Economic Security in the Scientifi c and Technological Sphere
Authors: Vlasova M. S. , Stepchenkova O. S.
Published: October 2019

Improving competitiveness in the scientifi c and technological sphere is one of the strategic directions for development of the national economy of the Russian Federation. In this regard, the scientifi c and technological potential and the degree of alignment of scientifi c, public and production resources come to the fore as the main components of the national power of the Russian Federation. This article addresses questions of selecting the criteria for assessing economic security in scientifi c and technological sphere amidst the formation of national innovative system in the Russian Federation using the triple helix model. The authors reviewed the existing systems of criteria and indicators, proposed matrix indicators to assess economic security in a scientifi c and technological fi eld according to the triple helix principle, calculated values of indicators according to the data from forty-three countries, made comparative analysis of the normalized partial indicators. The authors also formulated conclusion showing the strengths and weaknesses of scientifi c and technological sphere in the Russian Federation.
Code Mixing in Yowis Ben Film by Fajar Nugros
Authors: Ningrum Titi Surya , Sumarlam Sumarlam , Djatmika Djatmika
Published: October 2019

This research discussed code-mixing in Yowis Ben film from Fajar Nugros which is 80 percent using Javanese language. This paper aims to describe the forms and factors of using code-mixing. This paper is a kind of descriptive qualitative using observation-notification method (Simak-catat). Data in this study are oral data which is using information form. The population is all of the dialogs in Yowis Ben film. The result shows there are code-mixing word form, phrase, baster, word of frequent, and idiom dominantly code-mixing word form from Indonesian language insert to the Javanese language. Factors of using code-mixing are needs for a synonym, Social value, development and identification of new culture, low frequency of words, pernicious homonymy, oversight, and end (purpose and goal).
Exploring The Millennial Learners’ Attributes and Needs in Educational Environment
Authors: Larekeng Siti Hajar , Yassi Abdul Hakim , Najib Muhammad , Badaruddin Badaruddin
Published: October 2019

Millennial learners were born and raised in the digital era, with a variety of technology complete and sophisticated, such as: computer, laptop/notebook/netbook, smart Phone, iPads, PDA, MP3 player,  internet, and various other electronic devices. From childhood, they were familiar or introduced with the sophisticated gadgets that directly or indirectly influence their behavioral development and personality. Millennial generation has characteristics of behavior and personality that is different from previous generation. The attributes of millennial learners who grown up with technology may influence the current teaching strategy. In supporting the urgency of exploring the millennial learners’ attributes and needs in educational environment, the authors conduct a survey at Education Faculty of Universitas Muhammadiyah Parepare (UM Parepare), especially the learners who are majoring in English Education.The survey confirmed that those learners were exposed to various types of IT application. Some indications can be extracted from this study. Firstly, the learners were reasonably comfortable in utilizing various types of IT tools and expected the application to be embedded in the current application of learning. Secondly, the learners preferred to try to web in obtaining information, so the use of internet to access learning materials are highly needed. Last but not least, learners were mostly rated to adopt most ICT tools and devices.
Major oxide geochemistry and origin of the Troodos ophiolitic complex
Authors: Pantazis Theodoulos M.
Published: October 2019

New major element data from the layered and doleritic (static) gabbros, the plagiogranites, the sheeted complex and the volcanic series of the Troodos ophiolite complex clearly show that : the plutonic rocks are indiscutably the products of fractional crystallization and that the volcanics form continuous and smooth trends on oxide variation diagrams. This continuity in trend is also apparent in the case of the sheeted complex and the lower part of the volcanic series (Lower Pillow Lavas) when Miyashiro's diagrams are used.

The role of metamorphism and related phenomena such as calcitisation, albitisation, adularisation and silicification is emphasised. It is proved once more that, despite ocean floor metamorphism, the Troodos ophiolite was derived from tholeiitic magma with calc-alkaline affinities. Furthermore both geochemical and field evidence indicate that the plutonic, sheeted complex and volcanic rocks are consanguinal.
Présence de zircons hafnifères dans des pegmatites granitiques des Pyrénées ariégeoises ; leur relation avec les niobo-tantalates.
Authors: Fontan François , Monchoux Pierre , Autefage Francis
Published: October 2019

Zircons bearing a high percentage of hafnium have been found in pegmatite in several places of the phospholitic Pyrenean district, those zircons are constantly associated with niobotantalates. The study of these associations brings to light the very localized characteristics of the chemical equilibrium in pegmatites and also the hafnium percentage variations of zircons when in contact with niobotantalates and their high percentage of tantale.
Évolution hydrothermale de l'hawaiite d'Espalion (Aveyron). Hydrothermal evolution of the Espalion hawaiite (Aveyron, France)
Authors: Pillard François , Maury René Charles , Tournemire Robert , Massal Philippe
Published: October 2019

The hawaiite from the Puech de Vermus neck near Espalion (French Massif central) crystallized between 1 150 and 1 000 °C ; its hydrothermal alteration at about 200 °C developed an association with gyrolite, tacharanite, tobermorite, phillipsite, thomsonite, natrolite, calcite, smectite, chlorite. The solution now contained in the vesicles is of meteoric origin, with a participation of recent waters.
La fluckite, arséniate hydraté de calcium et manganèse CaMnH2(AsO4)2 • 2 H2O, une nouvelle espèce minérale
Authors: Bari Hubert , Cesbron Fabien , Permingeat François , Pillard François
Published: October 2019

Triclinic, P[-1], a = 8.440 (8.459), b = 7.608 (7.613), c = 6.958 (6.968) Å, α = 82.32° (82.21°), β = 98.30° (98.25°), γ = 95.53° (95.86°), V = 436.8 (438.6)Å³, Z = 2. Catti et al. (1980) describe its structure. The strongest lines in powder pattern are : 7.512 (10) (010) ; 3.528 (9) ([-1]20, 210) ; 3.266 (9) (012) ; 2,975 (8) (012) ; 3,767 (6) ([-2]10, 020) ; 2.688 (6) (220) ; 30 other lines are given and indexed. Qualitative analyses indicates Ca, Mn, As, H, and O as major elements, and Mg, Co, Fe, Ni, as minor elements. The theoretical formula CaMnH₂(AsO₄)₂ . 2 H₂O can be deduced from four quantitative analyses (2 chemical analyses and 2 electron microprobe analyses). This is confirmed by the structural study. Some Mn can be replaced by Mg and Co. Isolated fluckite crystals are prismatic (100), (010) and show a large curved termination with the forms (2[-3]3), (2[-3]1). Crystals of radial groups are prismatic (100), (110), (010) and can be flattened on (100) or (110). Large curved terminal face with (112), (233), (111), (332), (221), (331). The colour is very pale pink, but dark pink in Co rich varieties. Cleavages : (010) and (100) good, (101) indistinct. The optical properties of cleavage fragments are described. Low birefringence on (010) with n'm ≃ 1.624 ; medium on (100) with n'g ≃ 1.642 ; n'p ≃ 1.618. 2 V is very large. Thermal curves in air and helium are given. Total dehydration occurs between 200 and 400° and unidentified products are obtained. Fluckite was found in the Gabe Gottes-Saint Jacques vein of the old famous Sainte Marie-aux-Mines mining area (Vosges) ; it is associated with pharmacolite and picropharmacolite. It was formed as a reaction between a carbonaceous gangue and arsenic rich solution from the oxydized ores. It is easely distinguished from the other known arsenates, especially trough its X Ray powder pattern. The type specimen is kept in the École Nationale Supérieure des Mines, Paris. A few grams of the mineral have been collected. It is named after Pierre Fluck. The new species and name have been approved by the Commission of New Minerals and Mineral Names of I.M.A.
Fluckite, CaMn(HAsO4)2 • 2 H2O, a structure related by pseudo-polytypism to krautite MnHAsO4 • H2O
Authors: Catti Michele , Chiari Giacomo , Ferraris Giovanni
Published: October 2019

A l'aide d'un diffractomètre automatique (radiation MoKα), 1970 réflexions ont été mesurées sur un monocristal de fluckite de Sainte Marie-aux-Mines. Les paramètres de la maille sont : a = 8,459(2), b = 7,613(1), c = 6,968(1) Å, α = 82,21(1), β = 98,25(1), γ = 95,86(2)° ; Z = 2, groupe spatial P[-1]. La structure a été résolue par les méthodes directes et affinée jusqu'à R = 0,042 ; tous les atomes d'hydrogène ont été localisés. Les octaèdres de coordination de Ca et Mn, joints en chaînes [10(-1)], forment avec les groupes AsO₄ des couches (010) qui sont unies par des liaisons hydrogène seulement et répétées par le vecteur b. On observe une liaison hydrogène acide très longue (2,946 Å) dans la couche, et une liaison hydrogène bifurquée entre les couches. La structure interne des couches est presque identique à celle des couches présentes dans la krautite, avec la moitié des atomes de Mn remplacée par Ca ; toutefois l'orientation relative des couches et la disposition des liaisons hydrogène sont différentes dans les deux structures. Les effets structuraux de la substitution Ca/Mn dans la famille krautite˗fluckite˗haidingerite sont semblables à ceux observés pour Ca/Mg dans les familles magnésite˗dolomite˗calcite et forstérite˗monticellite˗olivine à calcium.
Structure cristalline de la sengiérite. Crystal structure of sengierite
Authors: Piret Paul , Declercq Jean-Paul , Wauters-Stoop Dominique
Published: October 2019

La structure cristalline de la sengiérite naturelle provenant de Shinkolobwe (Zaïre) a été déterminée. Formule : Cu₂[(UO₂)₂V₂O₈](OH)₂ . 6 H₂O. Système monoclinique ; groupe spatial P2₁/a ; a = 10,599, b = 8,093, c = 10,085 Å, β = 103,42° ; Z = 2. Type structural : carnotite. Les feuillets |(UO₂)₂V₂O₈|(n fois, chargé 2n⁻) sont reliés par des groupes Cu₂O₁₀ formés par deux bipyramides tétragonales partageant une arête.
Highly ordered triclinic K-feldspars from Mt. Pélago anatexites (Argentera Massif, Maritime Alps)
Authors: Blasi Achille , Pol Blasi Carla de
Published: October 2019

Dans les feldspaths alcalins microgranitiques optiquement non maclés des anatexites du Mt. Pélago dans le Massif de l'Argentera, Alpes-Maritimes, les phases sodiques exsolvées sont présentes seulement en très faibles quantités et les phases potassiques, d'après diffractométrie X sur poudres, montrent des teneurs en N[Or] très élevées, une symétrie triclinique, et des distributions Si, Al à degré d'ordre de modérément élevé à élevé qui semblent approcher la tendance d'ordre « one-step ». L'étude aux rayons X sur monocristaux de ces microperthites montre que l'association diagonale est très fréquente dans les phases potassiques et la macle de type M est presque toujours présente dans les phases sodiques. Des températures de cristallisation relativement faibles, mais plus élevées que la température d'inversion monoclinique˗triclinique, associées à des processus de refroidissement qui vraisemblablement n'étaient pas très lents en termes relatifs, pourraient avoir contrôlé la configuration présente des microperthites étudiées.
Une occurrence uranifère à sélénium et bismuth dans la ceinture métamorphique du leucogranite de Mortagne-sur-Sèvre (Vendée)
Authors: Ruhlmann François , Gillet Yves , Lissillour Joseph
Published: October 2019

La minéralisation filonienne du Retail, encaissée dans les formations métamorphiques de bordure du leucogranite de Mortagne est caractérisée par la présence au sein de la même structure minéralisée de trois ensembles minéralogiquement différents. Ils correspondent aux expressions minéralogiques de trois stades de cristallisation à partir de solutions hydrothermales appartenant à un seul et même phénomène minéralisateur. Un stade précoce uranifère à coffinite et pechblende auquel succède un stade sélénié représenté par une remarquable association clausthalite˗paraguanajuatite, et enfin, un stade sulfuré cuprifère. La réaction entre les minéraux séléno-bismuthifères et le stade cuprifère se traduit par le développement de l'association chalcocite˗wittichenite d'une part, et d'emplectite d'autre part. La position structurale de la zone minéralisée et la présence d'une association U — Se — Bi — Cu posent le problème de l'influence de la nature du milieu sur celle de la minéralisation.
Magnésiocarpholite, cookéite et euclase dans les niveaux continentaux métamorphiques de la zone briançonnaise. Données minéralogiques et nouvelles occurrences
Authors: Goffé Bruno
Published: October 2019

Les métasédiments alumineux du Dogger briançonnais se localisent en Vanoise et en Ligurie. En Vanoise, deux nouveaux types de magnésiocarpholite Si₂Al₂(Mg, Fe)O₆(OH)₄ sont décrits avec, pour l'un, des teneurs en Mg proches de 66 % et, pour l'autre, des teneurs de l'ordre de 80 %. Les paramètres de la maille de ces différentes magnésiocarpholites ont été calculés et reliés aux compositions respectives. L'augmentation de la teneur en Mg se traduit par une contraction du réseau. La première occurrence dans les Alpes occidentales, et dans ce type de roche, d'un alumino-silicate de béryllium néoformé, l'euclase, est mise en évidence. En Ligurie, la minéralogie des niveaux alumineux apparaît comme tout à fait semblable à celle de la Vanoise avec, en particulier, la présence de la magnésiocarpholite et de la cookéite.
Motif of struggle in the chronicles "The Cathedral Clergy" by Nikolai Leskov
Authors: Andreyeva Valeriya G.
Published: October 2019

The author of the article addresses history of the publication of the chronicles "The Cathedral Clergy" by Nikolai Leskov; she notes that the subject and the core conflict of the work collided with its publication in a number of magazines, and that only Mikhail Katkov realised the chronicle's importance and accepted it in his magazine "The Russian Messenger". In "The Cathedral Clergy", Nikolai Leskov looks at the world from a special perspective which opens his point of view as an eternity look, whereas what becomes the core conflict in the work, is confrontation of belief and unbelief of global, if not universal, scale. Realisation of one of the book's most significant motifs – motif of struggle – is analysed in the article. It is considered how Nikolai Leskov on a set of examples illustrates the heroes' active and energetic strength that is shown in advocacy of belief, in resistance to meanness and premeditated deception. The writer very thinly and skillfully shows that fight is not an intrinsic basis of righteous people, that all of them live under the law of love, however they cannot be passive observers in the world where the truth is profaned.
Faktor-Faktor Yang Mempengaruhi Terjadinya diabetes Melitus di Puskesmas Harapan Raya Tahun 2018
Authors: Imelda Sonta Imelda
Published: October 2019

Diabetes mellitus (DM) is a chronic multi-system disease associated with abnormal insulin production, inability to use insulin or both. The mortality rate due to DM disease worldwide reaches 1.5 million people in 2014. The prevalence of DM patients is estimated to reach 9% of the total world population. The prevalence of DM patients in Indonesia ranks 4th in the world with 12 million sufferers and is expected to increase to 21.3 million in 2030. The type of quantitative research with the design is descriptive, the research period is 11-13 February 2018. The population is 167 people, the sample is 118 people and the sampling technique is accidental sampling. The analysis technique performed is Univariate. The results of the study found that, of the 118 respondents who suffered from Diabetes Mellitus which affected the majority of 50-59 years old 70 respondents (59.4%), the majority of women were 72 respondents (61%), descendants who had a history of DM 80 respondents (68 %), Food Pattern Factors the majority are unhealthy 69 respondents (59%) and the majority of Physical Activity Factors are not often 88 respondents (74.6%). The conclusions from this study are the factors that most influence the occurrence of diabetes mellitus, namely factors of lack of activity and also the history of heredity and unhealthy eating patterns. Suggestions should the Puskesmas party improve diabetes mellitus counseling.

 

Keywords: Diabetes Mellitus, Factors affecting DM

References: 41 References (2005-2016)
Perubahan Tingkat Kecemasan Pasien Pre Operasi Dengan Terapi Murottal Al-Qur’an di RSUD Raden Mattaher Jambi
Authors: Parman Parman , Az Rasyidah , Sutinah Sutinah , Triyanto Agus
Published: October 2019

Pasien yang akan menjalani operasi, peningkatan tekanan darah dan nadi sering kali terjadi, salah satu penyebabnya adalah kecemasan yang menyebabkan penundaan operasi yang akan dijalani. Data WHO pada tahun 2013 mengemukakan bahwa jumlah pasien yang melakukan operasi mencapai angka 148 juta jiwa. Salah satu teknik distraksi keagamaan adalah terapi murottal Al-Qur’an. Penelitian ini bertujuan untuk mengetahui pengaruh terapi murottal al-qur’an terhadap perubahan tingkat kecemasan pasien pre operasi di RSUD Raden Mattaher Jambi. Penelitian ini merupakan penelitian kuantitatif dengan metode pra eksperimen dengan rancangan pretest posttest one grup design without control. Populasinya yaitu pasien yang menjalani operasi sebanyak 2902 pasien. Pengambilan sampel dilakukan dengan menggunakan teknik accidental sampling yaitu berjumlah 14 pasien pre operasi. Instrumen penelitian yaitu Amsterdam Preoperatif Anxiety and Information Scale (APAIS). Analisa data dalam penelitian ini secara univariat dan bivariat dengan menggunakan Uji Wilcoxon. Hasil analisis menunjukkan bahwa ada perubahan tingkat kecemasan pasien pre operasi dengan terapi terapi murottal Al-Qur’an dengan p-value 0,01 pada pasien pre operasi di RSUD raden Mattaher Jambi. Diharapkan penelitian ini dapat menjadi masukan dan informasi bagi pihak rumah sakit tentang pengaruh pemberian terapi murottal al-qur’an terhadap perubahan tingkat kecemasan pasien pre operasi agar dapat dilakukan pemberian terapi murottal al-qur’an dalam penanganan kecemasan.
Analisis Faktor-faktor Kualitas Pelayanan Terhadap Kepuasan Pasien Poliklinik Spesialis RSUD KH Daud Arif Kuala Tungkal tahun 2018
Authors: Zaimah Zaimah
Published: October 2019

Berdasarkan data menunjukkan bahwa jumlah pasien rawat jalan yang berobat di poliklinik Spesialis RSUD KH Daud Arif dari Januari – Juni 2018 mengalami penurunan dari setiap bulannya, namun di bulan Maret 2018 ada peningkatan. Survey awal yang telah dilakukan peneliti mengenai kepuasan Pasien tentang kualitas pelayanan kesehatan di Poliklinik Spesialis RSUD KH Daud Arif terhadap 10 pasien yang berkunjung ke Poliklinik Spesialis RSUD KH Daud Arif Kuala Tungkal, didapat bahwa 6 pasien mengatakan bahwa kurang puas dengan pelayanan yang didapatkan dan 4 pasien mengatakan sudah cukup puas dengan pelayanan yang didapat.

Penelitian ini bertujuan untuk menganalisis Faktor-faktor Kualitas Pelayanan Terhadap Kepuasan Pasien Poliklinik Spesialis  RSUD KH Daud Arif Kuala Tungkal tahun 2018. Jenis penelitian ini adalah cross sectional. Sampel dalam penelitian ini adalah sebagian pasien yang berobat ke RSUD KH Daud Arif Kuala Tungkal sebanyak 99 responden. Data dianalisis dengan menggunakan Chi-Squere dan Regresi Logistik.

Hasil penelitian menunjukkan terdapat hubungan yang signifikan tangible ( bukti fisik, reability ( keandalan), responsiveness ( daya tanggap), assurance ( jaminan), emphaty (empati)   terhadap kualitas  layanan di Poliklinik Spesialis RSUD KH Daud Arif Kuala Tungkal Tahun Tahun 2018 dengan nilai p – value = 0,000. Dan setelah melakukan uji logistik berganda dari 3 model didapatkan bahwa faktor yang paling dominan berpengaruh terhadap kualitas  pelayanan rumah sakit adalah Tangible ( bukti fisik ) dengan nilai exponen B 420.578 dengan nilai p = 0,000.

Dalam hal optimalisasi pelayanan kesehatan, yang juga didukung dengan avaibility mendukung alat-alat dan infrastruktur. Misalnya dibagian pendaftaran dapat dilakukan dengan menambahkan pendaftaran line, operator dan penambahan jumlah bangku diruang tinggu.
ANALISIS FAKTOR – FAKTOR YANG BERHUBUNGAN DENGAN PENYIMPANAN OBAT DI PUSKESMAS KOTA JAMBI TAHUN 2018
Authors: Poernomo Dwi Hery , Girsang Ermi , Nasution Sri Wahyuni , Ginting Crismis Novalinda
Published: October 2019

Obat merupakan salah satu intervensi kesehatan yang paling nyata dan paling dirasakan oleh pasien yang berkunjung ke fasilitas kesehatan. Di pelayanan kesehatan rujukan belanja obat dapat menyerap biaya sekitar  60-70%  dari total pengeluaran. Sedangkan di pelayanan kesehatan dasar pengeluaran untuk penyediaan obat antara 30 – 40 %.  Sesuai Jaminan Mutu (Quality Assurance) dalam pengelolaan dan pelayanan obat di Puskesmas sarana penyimpanan obat harus memadai baik kapasitas maupun kualitas, sehingga memungkinkan pengelolaan obat dan perbekelanan kesehatan baik. Tujuan Penyimpanan Obat di Puskesmas agar setiap obat yang diadakan dapat digunakan dengan baik, harus dihindari agar obat yang rusak / kadaluarsa karena proses penyimpanan atau tidak terpakai seminimal mungkin  atau tidak ada sama sekali. Begitu juga obat yang diperlukan harus tersedia setiap saat dibutuhkan, sehingga setiap kebutuhan obat pasien terpenuhi dengan cepat.  Metode penelitian adalah penelitian kuantitatif dengan rancangan penelitian Cross Sectional, besarnya sampel dalam penelitian sebanyak 20 orang petugas pengelola obat Puskesmas di Kota Jambi . Dari penelitian yang dilakukan diperoleh hasil bahwa penyimpanan obat di Puskesmas yang berada pada kategori baik sebanyak 12 puskesmas (60,0%) dan pada kategori kurang baik sebanyak 8 puskesmas (40,0%), selanjutnya dilakukan uji chi – squere terbukti bahwa ada hubungan bermakna antara pengetahuan, pelatihan, komitmen pimpinan Puskesmas, dan sarana dengan penyimpanan obat di Puskesmas.  Berdasarkan hasil penelitian ini disarankan kepada Dinas Kesehatan Kota untuk mengadakan evaluasi terhadap penyimpanan obat di Puskesmas, yang meliputi ketersediaan sarana penyimpanan, peningkatan pelatihan penyimpanan obat kepada petugas pengelola obat.
HUBUNGAN PENGETAHUAN IBU TENTANG DBD DENGAN PERILAKU PENCEGAHAN DBD PADA BALITA DI PUSKESMAS PAAL MERAH 1 KOTA JAMBI
Authors: Ardianto Oril
Published: October 2019

Latar Belakang : Menurut Word Health Organization populasi di dunia diperkirakan berisiko terhadap penyakit DBD mencapai 2,5-3 miliar terutama yang tinggal di daerah perkotaan di negara tropis dan subtropis. Saat ini juga diperkirakan ada 50 juta infeksi dengue yang terjadi diseluruh dunia setiap tahun. Diperkirakan untuk Asia Tenggara terdapat 100 juta kasus demam dengue (DD) dan 500.000 kasus DHF yang memerlukan perawatan di rumah sakit, dan 90% penderitanya adalah anak-anak yang berusia kurang dari 15 tahun. Metode : Jenis penelitian ini merupakan penelitian analitik dengan rancangan cross sectional. Tempat penelitian ini dilakukan di Puskesmas Paal I Kota Jambi dan penelitian telah dilakukan bulan September tahun 2014. Sampel dipilih dengan teknik accidental sampling sebanyak 84 orang. Pengumpulan data dalam penelitian ini dengan cara pengisian kuesioner menggunakan kuesioner. Analisis data dilakukan secara Univariat dan analisis bivariat dilakukan dengan uji chi-squere. Result : Sebanyak 28 responden (33,3%) mempunyai pengetahuan baik, sebanyak 38 responden (45,2%) mempunyai pengetahuan cukup dan sebanyak 18 responden (21,4%) mempunyai pengetahuan kurang baik tentang pencegahan demam berdarah pada balita. Sebanyak 34 responden (40,5%) melakukan pencegahan demam berdarah pada balita dengan baik, dan sebanyak 50 responden (59,5%) melakukan pencegahan demam berdarah pada balita kurang baik. Adanya hubungan antara pengetahuan ibu tentang demam berdarah dengan pencegahan demam berdarah pada balita di Wilayah Kerja Puskesmas Paal Merah I Kota Jambi dengan p value 0,006. Conclusion : Diharapkan petugas kesehatan melakukan penyuluhan kesehatan mengenai pencegahan demam berdarah pada balita agar pengetahuan yang responden dapatkan dapat diterapkan dan melakukan pencegahan demam berdarah pada balita dan mengajak pada kader untuk berperan aktif dalam memberikan informasi mengenai pencegahan demam berdarah pada balita.
El dilema de Otanes en América Latina
Authors: Berrios Espezúa Mario Gustavo
Published: October 2019

El destacado politólogo italiano Norberto Bobbio (1909-2004) escribió un libro muy interesante acerca de las formas de gobierno en la historia del pensamiento político (Bobbio, 1992), el mismo que empieza con una “célebre discusión” entre tres personajes persas: Otanes, Megabyzo y Darío, acerca de cuál debería de ser la mejor forma de gobierno a instaurarse en Persia. Otanes es el defensor del gobierno de muchos (democracia), Megabyzo defiende el gobierno de pocos (aristocracia) y Darío apuesta por el gobierno de uno (monarquía), la democracia de Otanes es la única forma de gobierno que garantiza la igualdad ante la ley. Durante el estudio de las formas de gobierno (desde Platón hasta Marx), Bobbio llega a la conclusión de que la mejor forma de gobierno de todas es la democracia; sin embargo, en América Latina, la democracia ha asumido diversos tonos e incluso algunas formas de gobierno nada democráticos se hacen pasar como democráticos. En este trabajo desarrollaremos algunos puntos referidos a la célebre discusión que reseña Bobbio y su importancia en el actual debate acerca de la mejor forma de gobierno en América Latina; en segundo lugar, presentaremos el contexto neoliberal en el que la democracia en América Latina se instaura a inicios del siglo XXI; seguidamente, comentaremos algunos datos sobre la democracia en tres países de la región: Venezuela, Ecuador y Perú.
Toxicidad de extracto acuoso de Stevia rebaudiana en Rattus norvegicus variedad Sprague Dawley
Authors: Todco Palza Julio Alberto , Diaz-Murillo Henry
Published: October 2019

Se evaluó la toxicidad del extracto acuoso de Stevia rebaudiana en Rattus norvegicus variedad Sprague Dawley durante 60 días. Se llevó a cabo en el Bioterio de Biología UNSA, Arequipa, durante los meses Agosto a Diciembre del 2012. Se utilizaron 16 Rattus norvegicus variedad Sprague Dawley distribuidas en cuatro grupos de 4 ratas cada uno: Al grupo control se le administró agua destilada (Grupo Control), al grupo experimental 2, 3, 4 se le administró vía orogástricaextracto acuoso de Stevia rebaudiana a dosis de 0.3, 0.6 y 0.9 g/Kg./día respectivamente. Se utilizó los kit de Wierner para la determinación de TGO, TGP, glucosa y creatinina. El peso corporal se midio en una balanza digital Omni 5300. Los tejidos evaluados (hígado, riñón y estomago) por el método de Harris. No se encontró diferencia significativa en la actividad de TGO y TGP en plasma de Rattus norvegicus variedad Sprague Dawley con tratamiento de extracto acuoso de Stevia rebaudiana en dosis de 0.3, 0.6 y 0.9 g/kg/día durante 60 dias (p>0.05). Se encontró disminución significativa en los niveles de glucosa en plasma de Rattus norvegicus variedad Sprague Dawley con tratamiento de extracto acuoso de Stevia rebaudiana en dosis de 0.3, 0.6 y 0.9 g/kg/día durante 60 dias (p>0.05). No se observó diferencia significativa en los niveles de creatinina en los tratamientos con extracto acuoso de Stevia rebaudiana 0.3, 0.6 y 0.9 g/kg/día respecto al grupo control (p>0.05). Se encontró una disminución significativa en el peso corporal de las ratas con tratamiento con extracto acuoso de Stevia rebaudiana 0.3, 0.6 y 0.9 g/kg/día respecto al grupo control (p<0.05). No se encontró alteración microscópica en Higado, riñón y estomago de Rattus norvegicus variedad Sprague Dawley con tratamiento de extracto acuoso de Stevia rebaudiana en dosis de 0.3, 0.6 y 0.9 g/kg/día durante 60 días.
PENGARUH EKSPEKTASI PELANGGAN, KUALITAS PRODUK DAN KEPUASAN PELANGGAN TERHADAP LOYALITAS PELANGGAN INTERNET TELKOMSEL DI BANDA ACEH
Authors: Rabiqy Yohandes
Published: October 2019

AbstractThis research aims to examine the factors that influence the level of internet customer loyaltyTelkomsel in Banda Aceh. The population of this research is the customer who use or are subscrib toInternet service Unlimited Telkomsel Flash, and a minimum for six months subscription. Multiplelinear regression analysis is used to determine the effect of variable customer expectations, productquality, and customer satisfaction is hypothesized to effect on customer loyalty. The results of multiplelinear regression analysis showed that the dominant factor that affect the customer loyalty is thevariable quality of the product, followed by a variable customer expectations, and the least effect oncustomer loyalty is customer satisfaction variables. The variables of this research are quite good inexplaining customer loyalty. The advice from the author to the company is that companies have tocreate products that are superior in quality, and always maintain the quality of the product toconstantly innovate on products tailored to the desires of customers to the product. Furthermore, thecompany have to pay attention to the complaints of customers by minimizing customer complaints.Keywords: Expectations, product quality, customer satisfaction, customer loyalty
SUMBERDAYA PENDORONG KEUNGGULAN BERSAING PERUSAHAAN
Authors: Rostina Cut Nina
Published: October 2019

AbstractUnderstanding sources of sustained competitive advantage has become a major area of research in strategic management. Building on the assumptions that strategic resources are heterogeneously distributed across firms and that these differences are stable over time, this article examines the link between firm resources and sustained competitive advantage. Four empirical indicator of the potential of firm resources to generate sustained competitive advantage- value, rareness, imitability, and substitutability- are discussed.Keywords: resources based view, kompetensi, sumberdaya
FAKTOR – FAKTOR YANG BERPENGARUH TERHADAP INDEKS HARGA SAHAM GABUNGAN PADA BURSA EFEK INDONESIA
Authors: Rabiqy Yohandes
Published: October 2019

Abstract: The purpose of this study was to determine the effect of the inflation, IBCinterest rate, and exchange rate on CSPI. The research was conducted on the Indonesia Stock Exchange (ISE) by using sample of 72 consisted of the entire variable monthly data during  2010  to  2015 with  the selection  of  the sample through a non probability sampling method by purposive sampling method and the data were analyzed with multiple linear regression analysis techniques. Based on the analysis found inflation, IBC interest rates, and exchange rates simultaneously affect the CSPI. The Inflation and IBC interest rates partially significant negative effect on the CSPI, this means an increase in inflation and IBC interest rates may result decrease value of CSPI. Exchange rates partially significant positive effect on CSPI. This means that the increase occurred in exchange rates can increase the value of CSPI.Kata kunci:   Inflasi, Suku Bunga, Kurs, Indeks Harga Saham Gabungan (IHSG)