bluuebunny/crossref_metadata_2025 huggingface dataset:
On the importance of π-π interactions in the structural stability of phycocyanins
Authors: Breberina Luka , Nikolic Milan , Stojanovic Srdjan , Zlatovic Mario
Published: February 2023

The influences of ?-? interactions in phycocyanin proteins and their environmental preferences were analyzed. The observations indicate that the majority of the aromatic residues in phycocyanin proteins are involved in ?-? interactions. Phenylalanine (Phe) and tyrosine (Tyr) residues were found to be involved in ??? interactions much more frequently than tryptophan (Trp) or histidine (His). Similarly, the Phe-Phe and Tyr-Tyr ?-? interacting pair had the highest frequency of occurrence. In addition to ?-? interactions, the aromatic residues also form ?-networks in phycocyanins. The ??? interactions are most favourable at the pair distance range of 5.5?7 ?, with a clear preference for T-shaped ring arrangements. Using ab initio calculations, we observed that most of the ?-? interactions possess energy from 0 to -10kJ mol-1. Stabilization centres for these proteins showed that all residues found in ?-? interactions are important in locating one or more such centres. ?-? interacting residues are evolutionary conserved. The results obtained from this study will be beneficial in further understanding the structural stability and eventual development of protein engineering of phycocyanins.
Topically Administered NOX4 Inhibitor, GLX7013114, Is Efficacious in Treating the Early Pathological Events of Diabetic Retinopathy
Authors: Dionysopoulou Stavroula , Wikstrom Per , Bucolo Claudio , Romano Giovanni Luca , Micale Vincenzo , Svensson Richard , Spyridakos Dimitris , Mastrodimou Niki , Georgakis Spiros , Verginis Panayotis , Walum Erik , Thermos Kyriaki
Published: February 2023

NADPH oxidases (NOXs) are major players in generating reactive oxygen species (ROS) and are implicated in various neurodegenerative ocular pathologies. The aim of this study was to investigate the role of a NOX4 inhibitor (GLX7013114) in two in vivo, experimental streptozotocin (STZ) paradigms depicting the early events of diabetic retinopathy (DR). Animals in the diabetic treated group received GLX7013114 topically (20 μL/eye, 10 mg/mL, once daily) for 14 days (paradigm A: preventive) and 7 days (paradigm B: treated) at 48 h and 4 weeks after STZ injection, respectively. Several methodologies were used (immunohistochemistry, Western blot, real-time PCR, ELISA, pattern electroretinography [PERG]) to assess the diabetes-induced early events of DR, namely oxidative stress, neurodegeneration, and neuroinflammation, and the effect of GLX7013114 on the diabetic insults. GLX7013114, administered as eye drops (paradigms A and B), was beneficial in treating the oxidative nitrative stress, activation of caspase-3 and micro- and macroglia, and attenuation of neuronal markers. It also attenuated the diabetes-induced increase in vascular endothelial growth factor, Evans blue dye leakage, and proinflammatory cytokine (TNF-α protein, IL-1β/IL-6 mRNA) levels. PERG amplitude values suggested that GLX7013114 protected retinal ganglion cell function (paradigm B). This study provides new findings regarding the pharmacological profile of the novel NOX4 inhibitor GLX7013114 as a promising therapeutic candidate for the treatment of the early stage of DR.

Article Highlights

NADPH oxidases (NOXs) are implicated in the early pathological events of diabetic retinopathy (DR). The NOX4 inhibitor GLX7013114, topically administered, reduced oxidative damage and apoptosis in the rat streptozotocin model of DR. GLX7013114 protected retinal neurons and retinal ganglion cell function and reduced the expression of pro-inflammatory cytokines in the diabetic retina. GLX7013114 diminished the diabetes-induced increase in vascular endothelial growth factor levels and Evans blue dye leakage in retinal tissue. GLX7013114 exhibits neuroprotective, anti-inflammatory, and vasculoprotective properties that suggest it may have a role as a putative therapeutic for the early events of DR.
Combination of Multiple Low-Risk Lifestyle Behaviors and Incident Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis of Prospective Cohort Studies
Authors: Khan Tauseef A. , Field David , Chen Victoria , Ahmad Suleman , Mejia Sonia Blanco , Kahleová Hana , Rahelić Dario , Salas-Salvadó Jordi , Leiter Lawrence A. , Uusitupa Matti , Kendall Cyril W.C. , Sievenpiper John L.
Published: February 2023

OBJECTIVE

Combined low-risk lifestyle behaviors (LRLBs) have been associated with a reduction in type 2 diabetes risk. This relationship has not been systematically quantified.

RESEARCH DESIGN AND METHODS

A systematic review and meta-analysis was conducted to assess the association of combined LRLBs with type 2 diabetes. Databases were searched up to September 2022. Prospective cohort studies reporting the association between a minimum of three combined LRLBs (including healthy diet) with incident type 2 diabetes were included. Independent reviewers extracted data and assessed study quality. Risk estimates of extreme comparisons were pooled using a random-effects model. Global dose-response meta-analysis (DRM) for maximum adherence was estimated using a one-stage linear mixed model. The certainty of the evidence was assessed using GRADE (Grading of Recommendations, Assessment, Development and Evaluations).

RESULTS

Thirty cohort comparisons (n = 1,693,753) involving 75,669 incident type 2 diabetes cases were included. LRLBs, with author-defined ranges, were healthy body weight, healthy diet, regular exercise, smoking abstinence or cessation, and light alcohol consumption. LRLBs were associated with 80% lower risk of type 2 diabetes (relative risk [RR] 0.20; 95% CI 0.17–0.23), comparing the highest with lowest adherence. Global DRM for maximum adherence to all five LRLBs reached 85% protection (RR 0.15; 95% CI 0.12–0.18). The overall certainty of the evidence was graded as high.

CONCLUSIONS

There is a very good indication that a combination of LRLBs that includes maintaining a healthy bodyweight, healthy diet, regular exercise, smoking abstinence or cessation, and light alcohol consumption is associated with a lower risk of incident type 2 diabetes.
Effect of COVID-19 on Type 2 Diabetes Self-Care Behaviors: A Rapid Review
Authors: Olausson Jill M. , Brady Veronica J. , Storey Susan
Published: February 2023

OBJECTIVE

The aim of this review was to describe how the coronavirus disease 2019 (COVID-19) lockdown affected the self-care behaviors of people living with type 2 diabetes.

Methods

A systematic rapid review was conducted using four electronic databases. Studies reporting on the lockdown’s impact on at least one of the self-care behaviors that were published from January 2020 through October 2021 were included. Findings were synthesized narratively, using the Association of Diabetes Care & Education Specialists ADCES7 Self-Care Behaviors as a framework. The methodological level of evidence and quality ratings of the articles were assessed using the Joanna Briggs Institute Appraisal Checklist.

Results

Fifteen articles were included. Most studies reported on at least five of the self-care behaviors. There were reported increases in diabetes-related stress, as well as in increases in dietary intake and changes in the timing of meals. Physical activity was reported to decrease. Overall, taking medications and glycemic self-monitoring of blood glucose (SMBG) were unaffected by the lockdown. Of the studies reporting glycemic outcomes, the lockdown appeared to have little negative effect. None of the articles assessed all the self-care behaviors. The self-care behavior of SMBG was the least assessed. Most articles had a medium level of evidence and a medium to high quality rating (scores >60%).

Conclusion

The findings from this review found the COVID-19 lockdown had a variable impact on diabetes self-care behaviors. Because the potential for future COVID-19 surges and/or other virulent transmissible diseases remains a concern, health care providers should continue to address the importance of self-care behaviors to mitigate the risk of poor health outcomes in people with diabetes.
The impact of different implantation sites and sex on the differentiation of human pancreatic endoderm cells into insulin-secreting cells in vivo
Authors: Saber Nelly , Ellis Cara E. , G.Iworima Diepiriye , Baker Robert K. , Rezania Alireza , Kieffer Timothy J.
Published: February 2023

Few studies have examined the differentiation of human embryonic stem cell (hESC)-derived pancreatic endoderm cells (PECs) in different implantation sites. Here, we investigate the influence of implantation site and recipient sex on the differentiation of hESC-derived PECs in vivo. Male and female mice were implanted with 5x106 hESC-derived PECs either under the kidney capsule, in the gonadal fat pad, or subcutaneously within macroencapsulation (TheraCyteTM) devices. Mice that received PECs within TheraCyteTM devices developed glucose-stimulated human C-peptide secretion faster than cells implanted under the kidney capsule or in the gonadal fat pad. Interestingly, hESC-derived PECs implanted under the kidney capsule in females developed glucose-stimulated human C-peptide faster than in males, and secreted higher levels of arginine-stimulated glucagon and GLP-1 than other implantation sites. Furthermore, hESC-derived grafts collected from the kidney capsule and gonadal fat pad sites displayed a mix of endocrine and ductal cells as well as contained cysts whereas TheraCyteTM device grafts displayed mostly endocrine cells and cysts were not observed. Here we demonstrate that the macroencapsulated subcutaneous site and the female recipient can promote faster differentiation of hESC-derived PECs to endocrine cells in mice. 
Learning Media Based on Local History in Improving the Quality of Distance Learning
Authors: Wijaya Ahmad Alim , Syarifuddin  , Asmi Adhitya Rol
Published: February 2023

Educators have attempted various strategies to make distance learning interesting and exciting. However, in the absence of proper preparation in terms of the use and utilization of technology, the efforts made by educators still need to be successful. The lack of attractiveness of distance learning by educators causes students to experience a decrease in their willingness and learning outcomes. This study aims to analyze audio-visual learning media's validity, practicality, and impact on student learning outcomes during distance learning. This study adopted the development research method using the ADDIE development model. The subjects of this study were 41 students and one educator who conducted distance learning on historical subjects. The results of the research obtained are audio-visual learning media based on local history with an average value of 4.34 in the very valid category and also feasible to be tested on students in distance learning. In addition, this learning media effectively influences student learning outcomes before and after using learning media by 45.5%. It proves that the local history audio-visual learning media effectively improves student learning outcomes in distance learning. The use of this learning media for distance learning depends on the facilities and infrastructure educators and students use. Therefore careful and appropriate preparation is needed to achieve an efficient and effective learning process.
Contemporary Tourism Fifth edition
Authors: Cooper Chris , Hall CM
Published: February 2023

A new and refreshing approach to the study of tourism, looking at the far reaching effects that the COVID pandemic has had on the industry and how it has been forced to change, or not, subsequently.
Edukasi Financial Ilegal Dalam Bentuk Pinjaman Online dan Investasi Online Berdasarkan Penilaian Otoritas Jasa Keuangan (OJK) Pada Koperasi Kelompok Wanita Tani “Melati Jaya” Kelurahan Sukamenanti Baaru Kecamatan Kedaton Kota Bandar Lampung
Authors: Wulan Mutiasari Nur , Dalimunthe Nindytia Puspitasari , Rusman Tedi , Nurdin Nurdin
Published: February 2023

Currently, Fintech does not only enter Banking Financial Institutions, but also Non-Bank Financial Institutions. This can be seen in Financial Technology products circulating on social media, namely online loans and online investments. This condition actually provides convenience to the community, but there is also a negative impact, namely people who are trapped in online loans and online investments. There are many findings of online loan products and illegal online investments, this creates unrest in the community. Therefore, there is a need for education regarding illegal online loans and illegal online investments in collaboration with the Financial Services Authority (OJK) so that the public, especially mothers, are more careful in choosing to use online loan services and online investment. The method we use in this PkM activity is to provide education to participants regarding illegal online loan products and illegal online investments based on the assessment of the Financial Services Authority (OJK). The purpose of this PkM activity is to provide education regarding illegal online loan products and illegal online investments based on the assessment of the Financial Services Authority (OJK) so that they are more careful in choosing online loan services and online investments. The object of this PkM activity is the Women Farmers Group "Melati Jaya" Sukamenanti Baru Village, Kedaton District, Bandar Lampung City.
Analisis Strategi Bisnis Pada Perusahaan Layanan Internet Fixed Broadband Menggunakan Matriks IFE-EFE-IE
Authors: Jordan Christianto Timothy , Gilroy Jacobus Theofilo , Yemima Eliana Ester , Wulanata Chrismastianto Imanuel Adhitya
Published: February 2023

The Covid-19 pandemic has had a significant impact on all community activities, one of which is the change in communication patterns that have been using face-to-face activities now switch to using technology devices to communicate remotely, so this has encouraged fixed broadband internet service providers to compete to provide excellent quality service to their customers. . The purpose of this study is to provide appropriate recommendations regarding business strategies that fixed broadband internet service companies can implement through analysis of the IFE-EFE-IE matrix. The research design used is quantitative through respondent data collection (survey) of 55 people who use fixed broadband internet services calculated using the Expert Choice application version 11. The data obtained were analyzed using the Internal Factor Evaluation (IFE) matrix, External Factor Evaluation Matrix ( EFE), and the Internal-External (IE) matrix. The study results suggest that the business strategies for fixed broadband internet service companies that can be implemented are market penetration strategies and product development strategies.
Factors Affecting Service Per Conception of Ongole Cross-breed Cattles in Tanjung Sari District
Authors: Wicaksana Kunaifi , Arifin Dani Nur
Published: February 2023

One of the parameters to see the reproductive performance of cattle is service per conception (S/C). The lack of information on important factors affecting S/C in Ongole Cross-breed (PO) cattles breeding underlies this research. The analysis in this research was linear regression using the MINITAB 16 application. The results of the research for service per conception (S/C) in Ongole Cross-breed (PO) cattles in Tanjung Sari sub-district were classified as ideal with a value of 1.29 ± 0.52. Each increase in the value of the BCS score will increase the S/C value. Each added age value at first married, it will increase the S/C value. Each added value of the parent's age will reduce the S/C value. The conclusion in this study is that S/C in PO cattles in Tanjung Sari District is 1.29 ± 0.52. Factors that affect the value of conception rate in PO cattles in Tanjung Sari district was the BCS score which was positively associated with S/C with a value of 0.553, age at first mated was negatively associated with S/C with a value of -0.434, and age parent was negatively associated with S/C with value of -0,114.
STUDY OF WATER PHYSICS, CHEMISTRY, AND BIOLOGY QUALITY IN SWAMP WATER HIGH TIDE CONDITIONS IN BANYUASIN REGENCY, SOUTH SUMATERA
Authors: Sa'adah Raudhatus , Puteri Rizki Eka , Sari Selly Ratna
Published: February 2023

This study was conducted in tidal lowland at Banyu Urip Village, Tanjung Lago District, Banyuasin Region, South Sumatera. Samples were collected two times. The water sample was collected during high tide in primary, secondary, and tertiary canals. The result showed the seasonal variation of physical and chemical water parameters such as temperature 27 – 30 ºC, pH 3 – 5, DO 3.7 – 4.5 mg/l, phosphate 0.01 – 0.02 mg/l, TSS 108 – 232 mg/l, and EC 11 – 107 µmhos/cm. This study also identified 10 classes and 10 genera of phytoplankton. It has potential as a natural food source. The result revealed that physical and chemical water quality parameters were still suitable for aquaculture based on Government regulation of Republic Indonesia number 82 year 2001 about water criteria class III for fisheries. Meanwhile, the great challenge of tidal lowland for fishery management is low pH. Therefore, pre-treatment to increase pH before fish rearing is required.
Deviation as Defamiliarization Technique in Written Igbo Poetry
Authors: Oraegbunam Chukwuebuka U.
Published: February 2023

Deviation in the literary parlance occurs when a speaker or writer deviates from the normal rules and standards of a language. By breaking the rule of language, poets create art from the language that a language group is familiar with. Previous studies on written Igbo poetry (WIP) focused mainly on the content of WIP, with little attention paid to the language of the modern Igbo poets (MIP). Consequently, there is a dearth of research on how deviation occurs in African literatures.  Therefore, through the lenses of Shklovsky’s defamiliarisation theory, this study examines WIP, with a view to describing the techniques used by MIP in achieving deviation, for the purpose of defamiliarising language in their works. Data consists of twenty poems randomly selected from eleven Igbo poetic texts, written between 1975, when WIP debuted to 2015, a period that marks the fourth decade of its existence. The poems studied were subjected to a qualitative analysis that focuses on the use of language to achieve deviation. Findings show that four types of deviation feature in WIP scene: syntactic, lexical, phonological and graphological. Syntactic deviation is achieved through the use of end-weight, focusing and topicalisation. Lexical deviation is the achieved through the use of coinages, lexical borrowing and dialectal deviation. Only apocope phonological deviation feature in WIP, while graphological deviation is done to ease pronunciation with a view to achieving rhythmic effect.
The Evolution of Cluj Fortress From Extramuros Area and the Imprint of the Geosite in the Geographical Landscape of Cluj-Napoca City
Authors:   PhD Candidate, Faculty of Geography, Babeș-Bolyai University, Cluj-Napoca, Romania. Email: paula.codrea@ubbcluj.ro., Codrea Paula , Rus Ioan ,   Faculty of Geography, Babeș-Bolyai University, Cluj-Napoca, Romania. Email: ioan.rus@ubbcluj.ro., Irimuș Ioan-Aurel ,   Faculty of Geography, Babeș-Bolyai University, Cluj-Napoca, Romania. Email: aurel.irimus@ubbcluj.ro., Rusu Raularian ,   Centre for Regional Geography, Faculty of Geography, Babeș-Bolyai University, Cluj-Napoca, Romania. Email: raularian.rusu@ubbcluj.ro.
Published: February 2023

"The Evolution of Cluj Fortress from Extramuros Area and the Imprint of the Geosite in the Geographical Landscape of Cluj-Napoca City. Cluj Fortress was built by the military garrison of the Habsburg Empire to have a defensive role in tragic periods. The site of its location was chosen possibly due to morphology, the presence of landforms developed on sandstones and conglomerates which led provided conditions for living and development in that place. The evolution of the area from extramuros to intramuros was shaped by the living necessities that the military garrison had to satisfy. By entering the area beyond the walls, “the world down there”, they had access to the means of satisfying their needs, to the necessary substance and energy exchange. The emergence of miserable households, mere holes in the slope, was possible due to the geological structure. They had a negative impact on the geographical landscape, due to the negative look of the slope, but also because of the precarious living conditions of the inhabitants of that area. The development of communities including disfavoured people determined miserable living conditions, while they tried to survive in different manners. By means of the used methodology, the paper highlights the evolution of Cluj Fortress since ancient times until today, and to emphasize the importance of the Fortress site from a scientific and anthropogenic point of view, by means of the geomorphosite inventory list. Keywords: evolution, Fortress, extramuros / intramuros, sandstones and conglomerates, geosite, geographical landscape, Cluj-Napoca, Romania. "
Perbandingan Status Nutrisi Pasien Stroke Iskemik Pertama dan Ulang di RSUP Dr. Hasan Sadikin Bandung
Authors:   Department of Neurology, Faculty of Medicine, Universitas Padjadjaran/ Dr. Hasan Sadikin General, Ayu Khairunnisa Shafa
Published: February 2023

Background and Objective: Stroke has various clinical manifestations that can cause low nutritional intake. Stroke patients can also experience recurrent stroke. This study aims to determine the comparison of nutritional status in patients with first and recurrent ischemic stroke based on Body Mass Index (BMI) and Subjective Global Assessment (SGA). Subject and Methods: This study is a comparative analysis of the medical records of patients with first and recurrent ischemic stroke at RSUP Dr. Hasan Sadikin Bandung period 2018−2019. The sample selection method was carried out by consecutive sampling with 118 patients for each group. Data analysis for nominal data was tested by Fisher’s exact test, for ordinal and numerical data tested by Mann Whitney test. Result: A total of 236 subjects in both groups of first and recurrent ischemic stroke patients consisting of 130 men and 106 women with an average age of 56,64±14,60 and 61,75±11,36 years, and the majority had risk factors for hypertension. Based on BMI, the majority of ischemic stroke patients were categorized as normal and obese in the first (33,05%) and obese in recurrent ischemic stroke (37,39%), p>0,05. SGA B rating (64,41% in the first and 66,95% in the recurrent ischemic stroke), p>0,05. Conclusion: There was no statistically significant difference in the nutritional status of first and recurrent ischemic stroke patients based on SGA and BMI, but the proportion of recurrent ischemic stroke patients had worse nutritional status. The majority of ischemic stroke patients are obese, in contrast to the SGA which shows that patients are mildly-moderately malnourished
Analysing Interaction in Science Classrooms
Authors: Danielsson Kristina , Bergh Nestlog Ewa , Jeppsson Fredrik , Tang Kok-Sing
Published: February 2023

One central issue for research in classrooms is to provide insights concerning characteristics of classroom interaction that can help teachers improve their teaching. In the present study, we analyse spoken interaction in one elementary physics classroom by the use of two different frameworks, targeting similar aspects of social communication, namely how discourse patterns shape the relations between participants. The two frameworks utilized are on the one hand analyses of the communicative approach according to Mortimer and Scott, combined with analyses of discourse patterns such as IRE-patterns, and on the other hand analyses related to the interpersonal meta-function in Halliday’s systemic-functional grammar, SFG. The aim was to highlight possibilities and limitations of the different frameworks. 

Our analyses reveal that the two analytical frameworks have partly the same, partly different affordances concerning what they can reveal about classroom interaction. The analyses of the communicative approaches have the potential of elucidating discursive patterns and power relations at a general level, while the analyses based on SFG can provide more details about the power relations in terms of how the participants actually structure their utterances. The results are also discussed regarding implications for education.
PEMBELAJARAN JARAK JAUH MENGGUNAKAN LEARNING MANAGEMENT SYSTEM DI MASA PANDEMI COVID-19
Authors: Astriani Linda , Ismah Ismah
Published: February 2023

ABSTRAKPembelajaran jarak jauh di masa pandemic covid-19 dilakukan pada semua jenjang dari Sekolah Dasar sampai Perguruan Tinggi. Ecampus fip umj adalah aplikasi berbasis web untuk kegiatan pembelajaran elearning. Platform ecampus fip umj pembelajaran bisa dilaksanakan secara online dari jarak jauh. Tujuan penelitian ini untuk menganalisa efektivitas pembelajaran menggunakan LMS Program Studi PGSD pada mata kuliah Pendidikan Matematika SD Awal. Partisipan pada penelitian ini adalah mahasiswa semester 2 Tahun Ajaran 2020/2021 sebanyak 79 mahasiswa. Pengumpulan data yang menggunakan kuisioner. Teknik pengumpulan data menggunakan data non tes bentuk observasi, kuisioner dan dokumentasi. Angket efektivitas menggunakan skala likert. Hasil survey menunjukkan rata-rata respon mahasiswa terdapat 39,8% mahasiswa setuju kemudahan mengakses ecampus, 40,98% mahasiswa setuju jika pemahaman materi dalam pembelajaran menggunakan ecampus, 40,5% mahasiswa setuju jika ecampus efektiv digunakan dalam pembelajaran daring, dan 41,8% mahasiswa setuju dalam penggunaan ecampus dalam kuis atau ujian mata kuliah Pendidikan Matematika SD Awal. PJJ tidak bisa 100% menggantikan pembelajaran secara konvensional (tatap muka) di dalam kelas tapi setidaknya agar roda pendidikan terus berputar dan tidak mati total lumpuh karena Covid-19.Kata kunci: Efektivitas, Pembelajaran Jarak Jauh, LMS, Pandemi Covid-19
THE STIGMA OF INDONESIAN SOCIETY ON COVID-19 PATIENTS AND HEALTH WORKERS BASED ON THE HEALTH BELIEF MODEL THEORY
Authors: Aprianti Aprianti
Published: February 2023

The number of covid-19 cases in Indonesia has increased significantly. So, the government recommend physical distancing. As a new disease, the policy caused the public worry. This triggers the community to give social stigma to Covid-19 sufferers and health workers. This research is a quantitative study with a cross sectional method. The Indonesian population aged 15 - 44 years, have access to the internet, not health workers, not students in health schools andÂ  willing to be respondents. The number of samples was 360 respondents. Bivariate data analysis used chi square test and multivariate using logistic regression. As many as 63.6% of respondents did not know their Covid status. Respondents gave a stigma of 50.8%. The variables related to the stigma given by the community to health workers and Covid-19 patients were perception of severity (p value = 0.037), self-efficacy (p value = 0.016) and perceived threat (p value = 0.001). The variable with the most dominant relationship is perceived threat with the value of Exp (B) = 3, 834. It is hoped that the need for education from health workers to the community about the covid-19 virus and how to overcome it so that people do not feel threatened and give stigma.
KEBIASAAN MAKAN MAKANAN ETNIK MINAHASA PROVINSI SULAWESI UTARA
Authors: D Kandou Grace
Published: February 2023

Indonesia memiliki banyak suku etnis diantaranya adalah elnis Minahasa. dengan beragam adat istiadatnya termasuk kebiasaan makan. Elnis Minahasa mempunyai kebiasaan makan yang cukup unik dengan beragam makanan khas yang sebagian besar diduga mengandung asam lemak jenuh tinggi. Sulawesi Utara merupakan salah satu daerah yang tinggi angka kematiannya akibat PJK. Dilakukan survey kebiasaan makan terhadap 528 etnis Minahasa di Kabupaten/Kota Provinsi Sulut. Jenis makanan yang sering dikonsumsi adalah 'babi garo rica ' (97%), ikan laut wokublanga (95%), tinorangsak (93%), babi kecap (91%), babi pular (79%), babi hulan (72%) RW(anjing) (70%)) sedangkan jenis sayuran seperli tinutuan (90%).
KINERJA BIDAN DALAM MENDUKUNG PROGRAM INISIASI MENYUSU DINI (IMD) DI KOTA PEKANBARU
Authors: Mardiah Mardiah , Indrawati Lipoeto Nur , GA Nursal Dien
Published: February 2023

Inisiasi Menyusu Dini (IMD) adalah pemberianASI segera pada bayi baru lahir sampai satujam pertama. Salah satu kunci keberhasilan program IMD ditentukan oleh kualitas kinerja bidan yang di pengaruhi faktor umur, lama kerja, pelatihan, tingkat pendidikan, status perkawinan, tingkat pengetahuan, sikap, motivasi, kepeminpinan dan imbalan. Penelitian ini untuk mengetahui faktor-faktor yang berhubungan dengan kinerja bidan dalam mendukung program IMD di Kota Pekanbaru tahun 2011. Menggunakan rancangan cross-sectional, di Kota Pekanbaru dengan sampel sebanyak 106 orang. Data dikumpulkan menggunakan kuesioner dan dianalisis secara univariat, bivariat dengan uji Chi-square dan multivariat menggunakanuji regres logistik dengan CI 95%. Hasil penelitian ini didapat bahwa bidan yang memiliki kinerja baik (5 1,9%), lebih dari separuh berusia tua (54,7%), lebih dari separuh sudah lama bekerja (53,8%), sebagian besar tidak pernah pelatihan (64,2%), pada umumnya tingkat pendidikan tinggi (92,5%), sebagian besar sudah kawin (87,7%), hampir separuh tingkat pengetahuan kurang (43,4%), hampir separuh bersikap negatif (51,9%), hampir separuh memiliki motivasi kurang (42,5%), hampir separuh kepemimpinan kurang (35,8%), dan hampir separuh imbalan kurang (42,5%). Hasil analisis bivariat didapat bahwa variabel umur, lama kerja, status perkawinan, sikap, motivasi, kepemimpinan dan imbalan tidak terdapat hubungan yang bermakna dengan kinerja bidan dengan p > 0,05. Sedangkan tingkat pelatihan, pendidikan dan tingkat pengetahuan memiliki hubungan yang bermakna dengan kinerja bidan dengan p < 0,05 . Hasil analisis multivariat didapat bahwa pelatihan merupakan variabel yang paling dominan mempengaruhi kinerja bidan dalam mendukungprogram IMD di Kota Pekanbaru tahun 2011. Diharapkan Dinas Kesehatan Kota Pekanbaru mengevaluasi kinerja bidan secara berkala dan memperhatikan faktor-faktor yang menyebabkan kinerja bidan yang belum optimal dalam pelaksanaan IMD dan memperbaiki faktor tersebut sehingga dapat meningkatkan kinerja bidan dimasa yang akan datang dalam rangka menurunkanAngka KematianBayi (AKB).
PENGARUH LINDI ( LEACHATE ) SAMPAH TERHADAP AIR SUMUR PENDUDUK SEKITAR TEMPAT PEMBUANGAN AKHIR ( TPA ) AIR DINGIN
Authors: Mahluddin Yatim Erni , Mukhlis Mukhlis
Published: February 2023

Tempat Pembuangan Akhir (TPA) Air Dingin terletak di Kecamatan Koto Tangah Padang merupakan tempat pembuangan akhir sampah yang berasal dari Kota Padang. TPA Air Dinginberoperasi dengan sistem open dumping dan belum adanya Instalasi khusus Pengolahan untuk lindi yang dihasilkan sehingga berpotensi untuk mencemari air sumur di sekitarnya. Penelitian ini dilakukan untuk mengetahuikarakteristik air lindi sampah,dan pengaruhnya terhadap kualitas air sumur disekitar TPA Air Dingin. Penelitian ini dilakukan dengan pengambilan sampel air lindi sampah pada kolam air lindi. Pengambilan sampel air sumur pada 4 lokasi sampel dengan mempertimbangkan jarak lokasi dengan TPA. Hasil yang diperoleh dari analisis dibandingkan dengan persyaratan dan baku mutu yang berlaku secara deskriptif dengan menggunakan tabel serta menghitung Indeks Pencemaran (IP). Hasil penelitian menunjukan parameter Wama, bau, TSS, BOD dan COD dari Air Lindi melampaui baku mutu. Parameter Cduntuk Air Lindi dan Air sumur masih dalam ambang batas. Parameter BOD, dan COD untuk air sumur sampai jarak 300m sudah melebihi ambang batas. Semua parameter untuk Air sumur dengan jarak 500 mdari TPA masihdalam ambang batas. IP untuk Sumur pantau adalah 1,99, IP untuk sumurjarak sampai 200 m adalah 1,91 dan IP untuk sumur dengan jarak sampai 300 m adalah 1,61 semuanya tergolong pencemaran ringan.
OMEGA 3 DAN KECERDASAN ANAK
Authors: Melva Diana Fivi
Published: February 2023

Kejadian gizi kurangdi Indonesia dari tahun ke tahun masih tinggi . Penyebab fingginya angka kejadiangizi kurang di Indonesia salah satunya diduga karena kurangnya konsumsi makanan sumber omega 3, EPA, DHA hubungan omega 3 dengan kecerdasan anak balita. Oleh sebab itu disarankan satn, untuk perlu dilakukan penelitian lebih lanjut mengenai hubungan konsumsi omega 3 dengan turnbuh-kembang anak, kedua, bagi ibuibu disarankan imtuk memperhatikan konsumsi makanan dari sumber omega 3 guna pengoptimalan tumbuhkembang anak, sebab secara teori selaput myelin dibentuk oleh lemak (asam lemak EPAJDHA). Hal ini jika terlaksana dapat memberikan dukungan terhadap programpemerintah di bidang promosi kesehatan.
Outcome of ventricular septal defect closure with the Nit-Occlud® Le VSD-Coil: single centre experience
Authors: Mohammed Mohammed , Tamimi Omar , Al-Mutairi Mansour , Alomrani Ahmed
Published: February 2023

The objective of this study was to review the outcome of patients who underwent transcatheter closure of ventricular septal defect (VSD) using Nit-Occlud® Leˆ VSDCoil. A retrospective study was carried out at King Abdulaziz Cardiac Center on all paediatric patients who underwent interventional VSD closure, during the period from 2011 and 2016. Data were collected, including demographic information, cardiac diagnosis, pre-operative diagnosis, intraoperative findings and postoperative events. Out of 46 patients, who were evaluated for VSD device closure, 17 of them were excluded; 24 patients out of 29 had successful closure of VSD using Nit-Occlud Leˆ VSDCoil (success rate of 83%), and five cases were referred to surgery. The age group was from 2 years up to 18 years. Almost 90% of VSD was the perimembranous (PM) type (26 patients) and 3 patients (10%) with muscular VSD. Ten of the 26 PM VSDs had TV accessory tissue partially covering the VSD defects. The hemodynamic assessment showed pulmonary blood flow to systemic blood flow ratio (Qp:Qs) > 1.5 in almost all the patients who underwent defect closure. Immediate closure of the defect was achieved in 11/24 patients (45%). In five additional patients, there was a tiny residual and eight with a small residual. With 6 months of follow-up, only six patients remained with tiny residual VSD defects. The Nit-Occlud® Leˆ VSD-Coil device has minimal effects on the aortic and tricuspid valves, and there was no permanent atrioventricular block, especially in patients with PM VSDs. Patients with a residual shunt should be followed, especially for haemolysis.
What Does Joy in Living Mean to Elderly Residents of Nursing Homes in Singapore? - The Full Study
Authors:   Singapore University Of Social Sciences, Dayanandan Swapna
Published: February 2023

This secondary publication is based on a full study to explore the meaning of Joy in Living to elderly residents of nursing homes in Singapore, the enabling and disenabling conditions to Joy in Living in nursing homes and how Person-centred Care can support Joy in Living in nursing homes.
Espécies vegetais utilizadas como pasto apícola por abelhas Apis mellifera L. (Hymenoptera, Apidae) em área de savana de Roraima, Brasil
Authors: Silva Silvio José , Cabral Gardênia , Maduro Cice , Maciel Edymeico
Published: February 2023

As abelhas Apis mellifera são mundialmente conhecidas por produzirem grandes quantidades de mel e por serem polinizadoras de diversas espécies vegetais nativas e cultivadas. Além do néctar, que é transformado em mel nas colmeias, A. mellifera também coletam pólen e resinas. O conhecimento das plantas úteis as abelhas para sustento e produção é de fundamental importância nos empreendimentos apícolas. Este trabalho apresenta uma relação de plantas visitadas pelas abelhas para coleta de pólen e néctar. As espécies vegetais, em um raio de 2000 metros das colmeias, foram observadas com o objetivo de verificar se havia visitação pelas abelhas A. mellifera e quais os materiais coletados, se pólen e/ou néctar. Ao final do trabalho foram coletadas 48 espécies vegetais distribuídas em 26 famílias. As Famílias Mimosaceae, Caesalpiniaceae, Sterculiaceae e Pontederiaceae foram as mais visitadas, respectivamente, com 6, 6, 4 e 3 espécies. Nove espécies foram visitadas apenas para coleta de pólen, 22 exclusivamente para néctar e 17 para ambos, pólen e néctar. Quanto ao porte, 41% das espécies foram de árvores, 21% ervas, 17% plantas aquáticas, 15% arbustos e 6% trepadeiras.
Türkiye’nin Düzey-2 Bölgelerinde Sosyo-Ekonomik Faktörlerin Malvarlığına Karşı İşlenen Suçlar Üzerine Etkileri: Sistem GMM Analizi
Authors: KAYA Ayten , TABAK Osman
Published: February 2023

Suç oranları ülkelerin kalkınmışlık seviyelerini gösteren önemli faktörlerden birisidir. Suç oranlarının yüksek olduğu ülkelerde genellikle belirsizlik ve güven probleminden dolayı yatırımcılar yatırım yapmaya çekinmekte bu durum ülkelerin ekonomik büyüme ve kalkınmaları üzerinde olumsuz etki yapmaktadır. Bu çalışmanın amacı, Türkiye’nin İstatistiki Bölge Birimleri Sınıflandırmasına göre Düzey-2 Bölgeleri (26 Bölge) için sosyo-ekonomik değişkenlerden işsizlik ve bölgenin aldığı göç sayısının malvarlığına karşı işlenen suç türlerinden hırsızlık ve gasp suçlarına etkilerini incelemektir. Bu kapsamda çalışmada 2008-2020 dönemi verileri kullanılarak Sistem Genelleştirilmiş Momentler Tahmincisi (Sistem-GMM) ile analiz gerçekleştirilmiştir. 26 bölge için hesaplanan Sistem GMM sonuçlarına göre işsiz sayısındaki artışın hırsızlık suçunu , göçmen sayısındaki (iç göç) artışın da gasp suçunu artırdığı tespit edilmiştir.
Havayolu Taşımacılığında Havayolu İşletmesi Seçimi ve Memnuniyetin Belirleyicileri: Üniversite Öğrencileri Üzerine Bir Araştırma
Authors: SARILGAN Ali Emre , BAKIR Mahmut
Published: February 2023

Bu çalışma üniversite öğrencilerinin seyahatlerinde havayolu işletmesi seçimini etkileyen faktörleri belirlemeyi ve bu faktörler arasındaki nedensel ilişkileri aydınlatmayı amaçlamaktadır. Bu doğrultuda, ilk olarak havayolu işletmesi seçimini etkileyen faktörlerin belirlenmesi amacıyla açımlayıcı faktör analizi yapılmıştır. İkinci aşamada ise elde edilen faktörler arasındaki yapısal etkileşimlerin modellenmesi ve anahtar faktörlerin belirlenmesi amacıyla yorumlayıcı yapısal modelleme analizi kullanılmıştır. Eskişehir’deki üniversite öğrencileri üzerinde yürütülen bu çalışmada, kolayda örnekleme tekniği kullanılarak 335 katılımcıya ulaşılmıştır. Uygulanan açımlayıcı faktör analizi neticesinde “Memnuniyete ilişkin faktör”, “Etkileşim kalitesi” ve “Fiyat” olarak adlandırılan üç faktör ortaya çıkmıştır. Havacılık yönetimi alanından üç uzmanın görüşlerine başvurulan ikinci aşamada ise elde edilen faktörler arasındaki hiyerarşik etkileşimin temelinde fiyat kriterinin yer aldığı ortaya konulmuştur. Bu çalışmanın belirli bir tüketici grubuna odaklanarak, üniversite öğrencilerinin havayolu işletmesi seçimini etkileyen faktörler arasındaki nedensel ilişkileri modellemesi bakımından literatüre katkı sunması beklenmektedir.
Problems of evaluating the organization’s information security culture
Authors:   Ministry of Science and Education Republic of Azerbaijan Institute of Information Technology, Mahmudova Rasmiyya
Published: February 2023

Nowadays, digitization of all areas of human activity leads to an increase in the number of information security incidents in organizations. From this point of view, the problem of information security culture in organizations becomes very relevant in modern times. Obviously, the majority of incidents related to information security violations in organizations are associated to the human factor. To overcome this problem, the research in the field of the evaluation of information security culture is urgent. Measuring and evaluating information security culture can enable an organization to identify its weaknesses in this area and take measures to eliminate them. This article examines various approaches to the concept of information security culture, and analyzes the affecting factors within the organization (management’s attitude towards information security, information security policy, information security awareness and employee’s behaviors). It also studies the documents adopted in the field of development and evaluation of information security culture in the European Union countries and the United States, and implemented projects. It analyzes proposed methods for measuring the information security culture in the organization using various methods. Moreover, the article reveals existing problems in this field and provides certain recommendations for their elimination. The methods of analysis and synthesis, comparison, generalization and systematic approach are used in this research.
Analysis of international experience in the field of teaching and assessment of language proficiency
Authors:   Ministry of Science and Education Republic of Azerbaijan Institute of Information Technology, Adiyeva Lala , Mahmudova Rasmiyya ,   Ministry of Science and Education Republic of Azerbaijan Institute of Information Technology
Published: February 2023

The article analyzes the existing international standards in the field of language teaching and proficiency assessment. Based on the Common European Framework of Reference (CEFR), which is promoted by the Council of Europe and used in language teaching and assessment in Europe and other countries, language proficiency levels, assessment, goals, CEFR Global Scale, global English language assessment programs similar to CEFR descriptors are studied. Information is provided on the works carried out on the application of CEFR international standard in Azerbaijan. The application of information and communication technologies, including automated speech recognition systems, in language learning, teaching and assessment are analyzed. The advantages of effective use of Information and Communications Technology (ICT) in the process of improving the knowledge and skills of language learners, checking and evaluating the development of language skills are indicated. In order to contribute to the implementation of the tasks ahead for the protection and development of our mother tongue with the application of ICT, suggestions are given for adapting the teaching and evaluation of the Azerbaijani language to the CEFR standard, taking into account different approaches to language teaching in the world experience.
Factors Influencing Competitiveness of MSMEs in East Java
Authors: R. Agus Baktiono
Published: February 2023

In East Java, there are numerous centers of Micro Small and Medium Enterprises (MSMEs) with each having its unique characteristics on the products. To determine the competitiveness level of MSMEs, there are numerous different perspectives possible to be used including the orientation of social capital, intellectual capital, entrepreneurship, technology, innovation, market, and competitiveness.In running the business, the MSME business sector has to be oriented towards the seven aspects in order that the business to be successful and able to survive in the present era of global competition. The independence of MSME business sector reflects the competitiveness level of the existing products available in the market.Competitiveness is the ability of a national economy to achieve a highly sustainable economic growth. It includes proper policies, suitable institutions, and other supporting economic characteristics that make a highly sustainable economic growth possible to achieve. The results of the study later found that out of 17 variables used as the forming factors namely Factor 1 (Component 1), Factor 2 (Component 2),Factor 3 (Component 3), and Factor 4 (Component 4) each had a high correlation coefficient of consecutively 0.768, 0.960, 0.786, and 0.901; meaning that each of the correlation levels was high as the value was > 0.5.Thus, Factor 1, Factor 2, Factor 3, and Factor 4 were said to be appropriate to be used representing the 17 independent variables which affected the competitiveness level of the MSMEs business sector in five cities in East Java, Indonesia.

Keywords: factor analysis; competitiveness
The Dynamics of Identity of Russian-Speaking Citizens of Ukraine Before and After the Revolution of Dignity
Authors: Synchuk Yevhen
Published: February 2023

The study analyzes the level of national identity of Russian-speaking citizens of Ukraine within certain time frames, namely before and after the events of the Revolution of Dignity 2013-2014. The issue of national identity in Ukraine has been studied since independence, and the events of 2014 related to Euromaidan, the occupation of Crimea and the war in Donbas have become an additional catalyst for studying the creation and change of national identity in Ukrainian society. One of the most important aspects of studying the identity of Ukrainians is the analysis of the identity of Russian-speaking citizens of Ukraine, who are an integral part of Ukrainian society and on which Russian propaganda, pro-Russian politicians and organizations in Ukraine worked purposefully. But the events that began in 2014 in Ukraine could have an even more significant impact on Russian-speaking citizens and therefore it is important to analyze this impact on the identity of Russian-speaking citizens, because certain changes in national identity in this group affect the political and social life of Ukraine. Sociological monitoring data from the Kyiv International Institute of Sociology (KIIS) were used for the analysis. Sociological results published by the institute in free access were analyzed through the method of descriptive statistics. For the analysis, three indicators were selected that are relevant for determining the national identity of Russian-speaking citizens in Ukraine. Among them: “attitude to the independence of Ukraine”, “interpretation of one's own national identity”, “assessment of the status of the Russian language in the state”. As for the attitude to independence, in 2007 in the South and East, Russian-speaking citizens treated independence quite differently. In the south of Ukraine there was a slight advantage in support of independence, and in the east on the contrary in anti-support. In 2017, the vast majority of citizens in both the East and the South supported independence. At the point of self-identification, Russian-speaking respondents began to identify more as Ukrainians and less as Russians, but in 2014 there was uncertainty about the self-identification of Russian-speaking citizens. In relation to the status of Russian language in Ukraine until 2014, there was greater support for the status of the second state language, but after 2014, Russian-speaking citizens did not consider the status of Russian as a second state language.
Pengenalan Dan Pelatihan Algoritma Pemrograman Menggunakan Aplikasi Scratch Untuk Siswa SMK YKWI Pekanbaru
Authors: Wandri Rizky , Suandi Daulay  , Yudhi Arta  , Anggi Hanafiah  , Jerika Mardafora
Published: February 2023

Perkembangan teknologi semakin meluas menjadikan kebutuhan akan Pendidikan Ilmu Komputer meningkat, salah satu dasar dari ilmu komputer adalah algoritma pemrograman. Dimana akan belajar membangun instruksi dengan coding tertentu yang mana belajar coding berdampak pada kreatifitas dan mengasah soft skills pada anak. Salah satu mitra pada kegiatan PkM ini adalah SMK YKWI yang memiliki jurusan TKJ yang mana hanya mempelajari instalasi PC, LAN, memperbaiki dan mempelajari program PC. Dari permasalahan yang ada, perlu adanya sebuah kegiatan yang mengenalkan mereka tentang luasnya ilmu komputer, mengenalkan peserta didik tentang dasar algoritma akan menarik minat mereka untuk mengembangkan ilmu ke arah yang lebih baik. Dalam penerapannya mengenalkan algoritma dasar ini adalah hal yang membosankan, maka perlu dilakukan perubahan pola pembelajaran menggunakan aplikasi scratch dengan membuat game sederhana. Tujuan dari pelaksanaan Kegiatan PkM ini adalah untuk meningkatkan pemahaman peserta terhadap pemrograman khususnya algoritma. Kegiatan dilakukan mencakup penyampaian materi terkait pemrograman dan algorima lalu praktik untuk mengimplementasikan algoritma dengan tema game sederhana. Dari kuesioner yang sudah disediakan, dapat ditarik penilaian, tingkat kepuasan peserta mencapai 100% dengan 78,9% peserta merasa Puas dan 21,1% sisanya peserta merasa sangat puas.