bluuebunny/crossref_metadata_2025 huggingface dataset:
Albumin Paclitaxel Combined with Intrapleural Infusion of Bevacizumab + Lobaplatin for the Second-Line Treatment of Patients with Non-Squamous Non-Small Cell Lung Cancer
Authors: Hou Junjie , Mi Xuguang , Liu Ning , Yang Ying , Qi Zhaoxue , Li Xiaonan , Lu Xiaodan , Jiang Xianzhuo , Yu Yingying , Zhou Ying , Ni Zhiqiang , Fang Yanqiu , Jin Ningyi
Published: June 2022

Objective. To investigate the clinical efficacy and safety of albumin paclitaxel combined with intrapleural bevacizumab + lobaplatin for patients with non-squamous non-small cell lung cancer (NS-NSCLC) with malignant pleural effusion (MPE) and analyze prognostic factors. Methods. A total of 126 NS-NSCLC patients were included in the study. Control group with 64 cases received intrapleural infusion of lobaplatin + intravenous albumin paclitaxel, and treatment group with 62 cases received additional intrapleural bevacizumab perfusion. Analysis was performed by collecting data about MPE, progression-free survival (PFS), overall survival (OS), and scores of quality of life. Results. In the treatment and control groups, objective response rate (ORR) was 51.6% and 31.3% (χ2 = 5.39,P=0.02), and disease control rate (DCR) was 91.9% and 71.9% (χ2 = 8.49,P=0.004), respectively. The main adverse reactions (≥grade 3) in the treatment group were thrombocytopenia, peripheral neurotoxicity, proteinuria, neutropenia, and nausea/vomiting, and in the control group, they were weakness, nausea/vomiting, anemia, and peripheral neurotoxicity. In the control and treatment groups, the median PFS was 6.2 (95% confidence interval (CI): 5.86–6.56) and 5.1 (95% CI: 4.956–5.191), and the median OS was 14.4 (95% CI: 12.681–16.113) and 10.6 months (95% CI: 8.759–12.391). The score of quality of life for treated patients was significantly higher than those before treatment and the control group, and the parameters included general health status (GH), role physical (RP), body pain (BP), social function (SF), and vitality (VT); pH, CD4+/CD8+ values, and vascular endothelial growth factor (VEGF) in the pleural effusion significantly affected the PFS and OS (P<0.05). Bevacizumab administration in patients with bloody pleural effusion did not increase the risk of pleural hemorrhage. Conclusion. The combination of albumin paclitaxel and intrapleural bevacizumab + lobaplatin is effective and may reverse the adverse events in patients with NS-NSCLC and MPE. The change of CD4+/CD8+ ratio before and after treatment is an independent and prognostic factor for patients with NS-NSCLC and MPE.
Angiotensin II Promotes White Adipose Tissue Browning and Lipolysis in Mice
Authors: Cai Zhaohua , Fang Liang , Jiang Yangjing , Liang Min , Wang Jian , Shen Yejiao , Wang Zi , Liang Feng , Huo Huanhuan , Pan Changqing , Shen Linghong , He Ben
Published: June 2022

Emerging evidence has revealed that all components of the renin-angiotensin system (RAS) are present in adipose tissue. Angiotensin II (Ang II), the major bioactive component of the RAS, has been recognized as an adipokine involved in regulating energy homeostasis. However, the precise role of Ang II in white adipose tissue (WAT) remodeling remains to be elucidated. In this present study, C57BL/C male mice were continuously infused with different doses of Ang II (1.44 mg/kg/d or 2.5 mg/kg/d) or saline for 2 weeks and treated with or without the Ang II type 1 receptor blocker valsartan. H&E staining and immunohistochemistry were conducted to investigate the white-to-brown fat conversion. The level of serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) was measured. RNA sequencing was employed to explore the differentially expressed genes and their enriched pathways between control and Ang II groups. Our results showed that Ang II substantially resulted in loss of body weight and fat mass. Most importantly, Ang II treatment induced WAT browning in mice, which was partially attenuated by valsartan treatment. Furthermore, Ang II perturbed the serum lipid profiles. Ang II treatment elevated serum levels of TC, TG, LDL-C, and HDL-C in mice. Mechanistically, thermogenesis, cell respiration, and lipid metabolism-associated mRNAs showed significantly increased expression profiling in Ang II-treated WATs compared with control WATs. Moreover, we found that Ang II treatment enhanced AMPK phosphorylation in adipocytes. Therefore, Ang II promotes WAT browning and lipolysis via activating the AMPK signaling pathway.
Characteristics of Pavement Cement Concrete Incorporating Steel Slag Powder
Authors: Tian Erbu , Liu Yamin , Cheng Xianpeng , Zeng Wuhua
Published: June 2022

After thermal braising and magnetic separation, steel slag is often ground into steel slag powder (SSP), which contains active silica (SiO2) and can be used as a cementitious material to replace part of the cement and applied in concrete. However, there have been relatively few studies on the influence of SSP on the performance of pavement cement concrete (PCC). In this paper, SSP was used as an admixture to replace part of the cement in the cement paste, cement mortar, and PCC, to investigate the effect of SSP on the fluidity of SSP-cement slurry, the mechanical properties, and the durability of PCC. Results showed that SSP can lead to the secondary hydration reaction with Ca(OH)2 in the cement paste and affect the hydration products, morphology, pore characteristics, and strength of the cement paste. When the SSP mixing amount was less than 20% and up to 1.3% superplasticizer was added, the fluidity of the cement slurry could be optimized. For the samples with the SSP mixing amount of less than 20%, the concrete compressive strengths were greater than 50 MPa, and the flexural strengths were greater than 5.0 MPa. As the SSP mixing amount increased, concrete displayed a better anticarbonization performance. Finally, using 15% SSP, the best performance in terms of the concrete antipermeability (chloride ion diffusion coefficient and electric flux) and frost resistance was achieved.
Research on the Development Support Strategy of Cultural Enterprises Based on Fish Swarm Algorithm under the Background of Public Health
Authors: Yu Lin , Hua Li , Ding Jiaran
Published: June 2022

Under the background of public health events, the government needs to adopt reasonable support strategies to help cultural enterprises tide over the crisis. However, the original analytic hierarchy process cannot be comprehensive and accurate analysis, resulting in that the government support strategy cannot play a role. Fish swarm algorithm is a comprehensive intelligent algorithm, which can comprehensively analyze the factors affecting the formulation of supporting strategies for cultural enterprises, and has the advantages of simple operation and strong analysis ability. Under this background, this paper puts forward a fish swarm model; this method is a comprehensive intelligent analysis method, which can help the government find the best support strategy from the perspectives of politics, economy, and society. In order to verify the effectiveness of the fish school model, this paper uses MATLAB software for verification; the results show that, in the support strategy classification, selection accuracy, and selection time, fish school model is superior to the analytic hierarchy process. Therefore, the fish swarm model can help the government to better choose supporting policies and help cultural enterprises tide over the crisis and improve the accuracy of formulating supporting strategies for cultural enterprises.
[Retracted] A Study on the Impact of Basketball on the Physical Fitness and Health of Adolescents Based on the Method of Correlation Analysis
Authors: Shao Xinbo , Sun Yuwei
Published: June 2022

Basketball can improve physical fitness, keep healthy, and become the main form of modern sports. However, basketball generally has the problem of unreasonable sports schemes and even reduces physical fitness. Therefore, finding an effective basketball program is an urgent problem to be solved at present. In order to improve the level of public health, this paper proposes a correlation analysis method to study the impact of basketball on teenagers’ health. The correlation analysis method is used to analyze the health data of adolescents, combined with the influence of basketball on fitness and the characteristics of basketball itself. Previous studies on basketball neglected comprehensive analysis and lack of correlation analysis of basketball indexes, resulting in unsatisfactory analysis results. The correlation analysis method can adjust the technical method, intensity, and program of basketball in combination with the physical development of teenagers. MATLAB simulation shows that the correlation analysis method can accurately analyze the impact of basketball on teenagers’ health, with an accuracy of 95%. Therefore, the correlation analysis method constructed in this paper can provide guidance for basketball and improve the health level of teenagers.
Study on the Evolution Laws of Anchoring Property of Surrounding Rock of Argillaceous Weakly Cemented Roadway in Water Environment
Authors: Zhang Weiguang , Chang Zhiguo , Bai Jianbiao , Wang Rui
Published: June 2022

This paper is aimed at studying the influence of composition and microstructure on the Jurassic weakly cemented rock mechanical properties. No. 1802 tailentry was used as the engineering background, located in the Danan Lake No. 5 mine in Xinjiang, China. The weakly cemented sandstone compositions were analyzed by using X-ray diffraction instrument. And the microstructure was observed by using a scanning electron microscope. The uniaxial compression experiment was carried out to investigate the mechanical characteristics by using MTS mechanics experimental system, and the uniaxial compressive strength, Poisson’s ratio, and elastic modulus were obtained. The relationships between the mechanical parameters that include the mineral composition, microstructural characteristics, uniaxial compressive strength (UCS), elastic modulus, cohesion, and friction angle of the weakly cemented sandstone and the water content were obtained. The attenuation of the anchorage force of the weakly cemented surrounding rock under different water-rich conditions was studied. The key reason of No. 1802 tailentry surrounding rock structure deterioration and roof fall was found. The model of a single anchor structure was established based on FLAC3D to study the mechanical response of a single anchor structure under different water contents and the distribution and evolution laws of bearing stress field, effective compressive stress, and anchor axial force. The influences of parameters such as water content, pretightening force, and anchor length on the preload diffusion effect of weakly cemented surrounding rock anchorage structures are obtained. The key to controlling the deterioration of the surrounding rock structure of the weakly cemented entry is to reduce the water content of the roof. The research results provide reference for the control of the entry surrounding rock under similar stratum conditions.
Agricultural Cold Chain Logistics Mode Based on Multi-Mode Blockchain Data Model
Authors: Si Yang
Published: June 2022

Aiming at the problem of massive data storage and transaction authority in the blockchain system in the data sharing transaction scenario, this paper proposes a blockchain system for the controllable sharing transaction of massive data. By designing the blockchain system model of the consortium chain and private chain, reconstructing the data structure of the block, and introducing the InterPlanetary File System (IPFS) technology, we adopt the off-chain storage method to solve the problem of high cost caused by too much data carried by the block. The isolation control of data resource transactions is realized by introducing identity authentication and channel mechanism, which meets the needs of different subjects for confidentiality of transaction data information. From the analysis results of cold chain logistics efficiency, in the five years from 2017 to 2021, the comprehensive cold chain logistics efficiency, pure technology cold chain logistics efficiency, and scale cold chain logistics efficiency of agricultural product cold chain logistics in a certain region have all reached above 0.9. The return to scale remains unchanged, and the cold chain logistics resources have been effectively allocated and reasonably utilized. The value of comprehensive cold chain logistics efficiency, pure technology cold chain logistics efficiency, and scale cold chain logistics efficiency in a certain month is less than 1, which means that the cold chain logistics efficiency is weak or ineffective. This shows that in these years, the infrastructure investment, cold chain technical support, and management level related to the cold chain logistics of agricultural products in a certain region need to be strengthened, and it is necessary to adjust the input-output structure and allocate resources reasonably. From 2018 to 2021, the total factor productivity of agricultural product cold chain logistics in a certain region is greater than 0.85, indicating that the level of total factor productivity is relatively high during this time period, and the increase in the efficiency of technical cold chain logistics is the main reason for the increase in total factor productivity.
White Blood Cell Count and Serum Cytokine Profile in Tropical Hardwood Workers in Kumasi
Authors: Ennin Isaac Ekow , Frempong Margaret Agyei , Dodoo Daniel , Yeboah Francis A. , Maalman Raymond Saa-Eru
Published: June 2022

Background. Occupational exposure to wood dust particles has long been reported of its associated varying degrees of negative health effects due to different extractive chemicals present in the various timber species. However, tropical hardwood is also reported to have higher levels of extractive chemicals of antihistamine, antioxidant, and anti-inflammatory properties. In Ghana, woodworkers have for years been exposed to wood dust from mixed tropical hardwood species, with little or no protective equipment such as nose masks, yet with less significant respiratory conditions. This study seeks to investigate the serum cytokine profile in tropical hardwood workers in Kumasi to provide a better understanding of the immunoregulatory pattern activated in the woodworkers. Method. The study was carried out among woodworkers, teachers, and security men located in Kumasi. A cross-sectional sampling of adult male workers was selected to participate in the study (86 woodworkers and 89 nonwoodworkers). Participants donated blood collected by venepuncture into EDTA tubes and spun to separate serum for cytokine assay. Cytokines including IFN-gamma, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12, IL-13, and IL-17 were assayed using the Human Premixed Multianalyte Kit (R&D System, Inc., Minneapolis, USA) following the manufacturer’s procedure. The cytokine levels were quantified using the Luminex

∗

200 analyser. Results. The mean concentration levels for the various cytokines were significantly different (

p
<
0.05

) between woodworkers and nonwoodworkers except IL-2. There were significantly increased levels of Th1 and Th2 cytokines expressed in the woodworkers more than the nonwoodworkers. Conclusions. The results from this study reveal that exposed woodworkers of mixed tropical hardwood species show a high level of Th1 and Th2 cytokines in their serum than nonwoodworkers.
Analysis and Application of Vibration Damping Hole in Tunnel Working Face Based on Grey Correlation Analysis
Authors: Duan Baofu , Zhengxin Zhang , Chunwu Zhang , Sun Zongjun
Published: June 2022

In the process of tunnel blasting construction, certain vibration hazards will be caused to adjacent buildings. Therefore, it is necessary to explore feasible vibration reduction measures in the construction process. Combined with field measurement and numerical calculation, the law of vibration reduction effect of vibration reduction holes in the blasting construction of subway tunnels is analyzed. The gray correlation theory is used to determine the influence degree of vibration reduction hole parameters on the vibration reduction effect; each parameter is clarified, and the primary and secondary relationship of each parameter in the vibration reduction effect is clarified. Among them, the effect of damping hole spacing is particularly obvious. Combined with numerical calculation and comprehensive analysis of on-site construction effects, it is found that during the construction process, the distance between the vibration damping holes is 120 mm, the distance between the vibration damping holes and the explosion source is 2000 mm, the diameter of the vibration damping holes is more than 120 mm, the depth of the vibration damping holes is 1200–1500 mm, and double-row vibration-damping hole spacing is 50–100 mm, which can achieve a better vibration-damping effect. The research results will provide a reference vibration reduction technology for the blasting construction of urban shallow tunnels and have certain reference value and guiding significance for the blasting scheme design and vibration control of similar projects.
Effects of Amiodarone and Esmolol for Heart Rate and Cardiovascular Changes
Authors: Wang Hao , Lei Fengping , Bai Lei , Zhang Anping
Published: June 2022

Objective. To probe into the effects of amiodarone and esmolol for heart rate disorders and myocardial infarction. Methods. 76 cases of cardiopathy in our hospital from July 2019 to October 2021 were analyzed for myocardial infarction. The control group applied amiodarone treatment. Blood pressure, treatment effect, adverse reactions, myocardial marker levels, electrocardiogram, and heart function indicators were compared. Results. There were no statistical differences in two groups of diastolic pressure (

P
>
0.05

). The analysis of the systolic pressure in the study group was greater than the control group (

P
<
0.05

); The effective rate was higher than that of the control group (

P
<
0.05

); the incidence of adverse reactions in the study group and control group was 28.95% and 31.58%, respectively, and there was no statistically significant difference between groups (

P
>
0.05

). The standards of markers were significantly reduced compared with the control group (

P
<
0.05

). After treatment, the heart rate of the two groups was significantly reduced, and the QT intervals were significantly shortened. But compared with the control group, reduction was larger in the research group (

P
<
0.05

). Compared with the control group, the resolution rate was higher (

P
<
0.05

). After treatment, the two groups of quality of life were significantly increased, and compared with the control group, the increase in the quality of life of the study group was greater (

P
<
0.05

). Conclusion. Application of amiodarone and esmolol joint treatment can improve the quality of life, improve the level of heart function and myocardial marker, and can reduce Q-T intervals and prognosis. Therefore, amiodarone and esmolol treatment is worth promoting.
Regulatory Programs of B-cell Activation and Germinal Center Reaction Allow B-ALL Escape from CD19 CAR T-cell Therapy
Authors: Im Nam Gyu , Guillaumet-Adkins Amy , Wal Megha , Rogers Anna J. , Frede Julia , Havig Claire C. , Yang Jing , Anand Praveen , Stegmann Sarah K. , Waldschmidt Johannes M. , Sotudeh Noori , Niu Leili , Voisine Jordan , Schweiger Michal R. , Grassberger Clemens , Lohr Jens G. , Knoechel Birgit
Published: June 2022

Chimeric antigen receptor (CAR) T-cell therapy has led to tremendous successes in the treatment of B-cell malignancies. However, a large fraction of treated patients relapse, often with disease expressing reduced levels of the target antigen. Here, we report that exposing CD19+ B-cell acute lymphoblastic leukemia (B-ALL) cells to CD19 CAR T cells reduced CD19 expression within hours. Initially, CD19 CAR T cells caused clustering of CD19 at the T cell–leukemia cell interface followed by CD19 internalization and decreased CD19 surface expression on the B-ALL cells. CD19 expression was then repressed by transcriptional rewiring. Using single-cell RNA sequencing and single-cell assay for transposase-accessible chromatin using sequencing, we demonstrated that a subset of refractory CD19low cells sustained decreased CD19 expression through transcriptional programs of physiologic B-cell activation and germinal center reaction. Inhibiting B-cell activation programs with the Bruton's tyrosine kinase inhibitor ibrutinib increased the cytotoxicity of CD19 CAR T cells without affecting CAR T-cell viability. These results demonstrate transcriptional plasticity as an underlying mechanism of escape from CAR T cells and highlight the importance of combining CAR T-cell therapy with targeted therapies that aim to overcome this plasticity.

See related Spotlight by Zhao and Melenhorst, p. 1040
The Everted Amygdala of Ray-Finned Fish: Zebrafish Makes a Case
Authors: Mueller Thomas
Published: June 2022

The amygdala, a complex array of nuclei in the forebrain, controls emotions and emotion-related behaviors in vertebrates. Current research aims to understand the amygdala’s evolution in ray-finned fish such as zebrafish because of the region’s relevance for social behavior and human psychiatric disorders. Clear-cut molecular definitions of the amygdala and its evolutionary-developmental relationship to the one of mammals are critical for zebrafish models of affective disorders and autism. In this review, I argue that the prosomeric model and a focus on the olfactory system’s organization provide ideal tools for discovering deep ancestral relationships between the emotional systems of zebrafish and mammals. The review’s focus is on the “extended amygdala,” which refers to subpallial amygdaloid territories including the central (autonomic) and the medial (olfactory) amygdala required for reproductive and social behaviors. Amphibians, sauropsids, and lungfish share many characteristics with the basic amygdala ground plan of mammals, as molecular and hodological studies have shown. Further exploration of the evolution of the amygdala in basally derived fish vertebrates requires researchers to test these “tetrapod-based” concepts. Historically, this has been a daunting task because the forebrains of basally derived fish vertebrates look very different from those of more familiar tetrapod ones. An extreme case are ray-finned fish (Actinopterygii) like zebrafish because their telencephalon develops through a distinct outward-growing process called eversion. To this day, scientists have struggled to determine how the everted telencephalon compares to non-actinopterygian vertebrates. Using the teleost zebrafish as a genetic model, comparative neurologists began to establish quantifiable molecular definitions that allow direct comparisons between ray-finned fish and tetrapods. In this review, I discuss how the most recent discovery of the zebrafish amygdala ground plan offers an opportunity to identify the developmental constraints of amygdala evolution and function. In addition, I explain how the zebrafish prethalamic eminence (PThE) topologically relates to the medial amygdala proper and the nucleus of the lateral olfactory tract (nLOT). In fact, I consider these previously misinterpreted olfactory structures the most critical missing evolutionary links between actinopterygian and tetrapod amygdalae. In this context, I will also explain why recognizing both the PThE and the nLOT is crucial to understanding the telencephalon eversion. Recognizing these anatomical hallmarks allows direct comparisons of the amygdalae of zebrafish and mammals. Ultimately, the new concepts of the zebrafish amygdala will overcome current dogmas and reach a holistic understanding of amygdala circuits of cognition and emotion in actinopterygians.
Mechanisms of Fetal Adaptation to Chronic Hypoxia following Placental Insufficiency: A Review
Authors: Ramirez Zegarra Ruben , Dall’Asta Andrea , Ghi Tullio
Published: June 2022

Placental insufficiency is associated with reduced oxygen and nutrient supply to the fetus, which may result in fetal growth restriction (FGR). In an attempt to cope with the hostile intrauterine environment, FGR fetuses respond through metabolic, endocrine, vascular, cardiac, behavioral, hematological, and immunological adaptive mechanisms. However, permanent sequelae may result from such adaptive mechanisms. In this review, we describe the mechanisms of fetal adaptation to the hostile intrauterine environment in FGR of uteroplacental origin and detail their pathophysiology and potential implications for the extrauterine life of the individual.
Two Approaches of the Spring North Atlantic Sea Surface Temperature Affecting the Following July Precipitation over Central China: The Tropical and Extratropical Pathways
Authors: Chen Lin , Li Gen , Lu Bo , Li Yanping , Gao Chujie , Long Shang-Min , Li Xinyu , Wang Ziqian
Published: June 2022

The spring tripole sea surface temperature (SST) anomalies in North Atlantic are an outstanding regional mode of interannual variability. Based on the observed and reanalyzed datasets during 1979–2019, this study reveals the relationship and linking mechanism between the spring tripole North Atlantic SST anomalies and the central China July precipitation (CCJP). Results show that the tripole SST anomalies, especially the warm SST anomalies in the tropical North Atlantic (TNA) and the subpolar North Atlantic (SNA), often cause surplus CCJP through the tropical and extratropical pathways. On the one hand, the spring TNA SST warming induces a pan-tropical climate response with the cooling in the central equatorial Pacific and the warming in the Indo-western Pacific until the following July through a series of air–sea interactions, helping maintain an anomalous anticyclone over the northwest Pacific and transport more warm humid flows to central China. On the other hand, the spring TNA and SNA SST warming persist into the following July and then emanate a wave train extending from the SNA throughout the Eurasian continent to East Asia, which induces an anomalous anticyclone over North China with its southeast flank transporting more cold air to central China. The warm humid flows from the south against the cold air from the north are conductive to the local ascending motion, favoring the increased CCJP. Our results highlight both the tropical and extratropical teleconnection pathways of the North Atlantic SST anomalies affecting the CCJP. This suggests an important seasonal predictor of the regional climate.

Significance Statement

July is the peak rainy month of central China, with heavy precipitation occurring frequently and often causing serious impacts on the local production and livelihood of millions of people. This study finds that the spring tripole sea surface temperature anomalies in North Atlantic induced by the North Atlantic Oscillation can exert significant impacts on the following July precipitation over central China through both the tropical and extratropical pathways. This improves our understanding of the causes of the surplus July precipitation over central China and has important implications for the seasonal predictability of the regional climate.
Racial Disparities in Colorectal Cancer Care for Black Patients: Barriers and Solutions
Authors: Balan Naveen , Petrie Beverley A. , Chen Kathryn T.
Published: June 2022

Racial disparities in colorectal cancer for Black patients have led to a significant mortality difference when compared to White patients, a gap which has remained to this day. These differences have been linked to poorer quality insurance and socioeconomic status in addition to lower access to high-quality health care resources, which are emblematic of systemic racial inequities. Disparities impact nearly every point along the colorectal cancer care continuum and include barriers to screening, surgical care, oncologic care, and surveillance. These critical faults are the driving forces behind the mortality difference Black patients face. Health care systems should strive to correct these disparities through both cultural competency at the provider level and public policy change at the national level.
Preschool and Child-Care Expulsion: Is it Elevated for Autistic Children?
Authors: Blacher Jan , Eisenhower Abbey
Published: June 2022

Viewed through a social justice lens, preschool expulsion is an educational equity issue. This study focused on prior expulsion from preschool and child-care in a longitudinal study of 203 autistic children, ages 4 to 7. By parent report, 16%—one out of six autistic children—had been expelled from a preschool or child-care setting prior to elementary school; average age when expelled was 3.3 years. Expulsion history and reasons for expulsion were determined from parent report. Previously-expelled children went on to experience more conflict and dependency in their current student-teacher relationships. They also experienced greater teacher-reported externalizing symptoms than non-expelled children; these constituted the only child characteristics that distinguished expelled and non-expelled children. Children were more likely to be expelled from private versus public programs, suggesting a particular need for policies and practices supporting inclusion in private settings. Future work that examines contextual factors exacerbating expulsion risk is warranted.
Advance Selling in Marketing Channels
Authors: Li Krista J. , Li Xi
Published: June 2022

Manufacturers and retailers often advance sell seasonal products or services (e.g., holiday decorations, summer or winter entertainment). The authors examine advance selling in marketing channels to offer several insights. First, it is well established that a decentralized channel suffers from the issue of double marginalization; that is, the manufacturer and retailer both add positive margins when setting their prices, which results in inefficiently high retail prices. The authors find that, under a dynamic wholesale-price contract, advance selling can alleviate this double-marginalization problem and benefit the manufacturer, the retailer, and consumers. Second, the benefit of advance selling diminishes with the product's holding cost, the retailer's stockpiling ability, and the manufacturer's commitment to spot wholesale price. Third, with wholesale-price commitment, advance selling benefits the manufacturer and consumers but hurts the retailer; the manufacturer is better off making a price commitment only when its product's holding cost is sufficiently low and worse off otherwise. Last, the retailer's stockpiling ability decreases its own profit under a dynamic contract but increases it under a commitment contract.
LGB Service Members’ Relationship Status, Satisfaction, and Well-Being: A Brief Report
Authors: Savarese Elizabeth N. , Collazo Jessica , Evans Wyatt R. , Balsam Kimberly F.
Published: June 2022

Recently, the legal landscape for sexual minorities in the United States has changed dramatically, prompting empirical research on lesbian, gay, and bisexual (LGB) couples and LGB service members. This study examined the relationship characteristics and mental health of LGB service members in couple relationships and compared partnered and single LGB service members. A total of 238 LGB service members completed an anonymous survey, including questions about demographics, identity, military experiences, and mental health symptoms. Results of descriptive and exploratory analyses revealed no significant differences in mental health between partnered and single participants. However, partnered individuals reported higher outness and lower internalized homophobia compared with their single counterparts. Analyses also revealed negative associations between relationship satisfaction and mental health symptoms among partnered participants. Among the first to examine LGB service members’ romantic relationships, the results of this study have important clinical and policy implications and inform next steps in researching this population.
“You Cannot Make Friends at Work”? Relatedness in and beyond the Workplace and the Reconfiguration of Kinship and Gender in Urban China
Authors: Peng Xinyan
Published: June 2022

Based on ethnographic fieldwork conducted in the form of immersive research in corporate Shanghai, this article demonstrates how white-collar women in urban China crafted relatedness in the interstitial times and spaces of and beyond the workplace. It brings to light how the precarious nature of work and the workplace environment shaped the precarious nature of relatedness established by those women who worked together. Though aware of the assumed lack of sociability and interpersonal trust as well as the fleeting and momentary ties formed in urban and corporate spaces defined by mobility and instability, white-collar women who worked together developed ties of relatedness to express their own desired understanding of the self and familial and gender roles. Forms of relatedness produced among white-collar women in and beyond the workplace occupy a space between home and work, reconceptualize women’s roles and places in family life, and reconfigure kinship and gender.
How do renewable energy consumption, financial development, and technical efficiency change cause ecological sustainability in European Union countries?
Authors: Zhen Zhang , Ullah Sami , Shaowen Zhan , Irfan Muhammad
Published: June 2022

Achieving ecological sustainability is a critical issue of the current era, and researchers are striving to find viable solutions for sustainable development and ecological wellbeing. This study is an effort to examine the ecological consequences of renewable energy (REC), financial development (FD), and technical efficiency (TE) in 27 countries of the European Union (EU), time ranges from 1980 to 2018. We used second-generation econometric techniques to consider the cross-sectional dependency in the model and the CS-ARDL method to estimate the long-run dynamics of the variables. The Westerlund cointegration technique confirmed the long-run association among REC, FD, TE, and ecological footprint (EF). Furthermore, CS-ARDL results revealed a positive influence of FD on EF, indicating FD is a significant contributor to the ecological footprint of the EU. However, REC and TE promote ecological sustainability in the EU, as both factors negatively affect the EF. Furthermore, the interaction of FD and TE is also estimated to mitigate EF in sample countries. The study recommends that government policies in EU countries must be skewed towards promoting renewable energy usage, lending in green and energy-efficient technology, and technological advancement in the production process.
Biocompatibility of Human Induced Pluripotent Stem Cell–Derived Retinal Progenitor Cell Grafts in Immunocompromised Rats
Authors: Han Ian C. , Bohrer Laura R. , Gibson-Corley Katherine N. , Wiley Luke A. , Shrestha Arwin , Harman Brynnon E. , Jiao Chunhua , Sohn Elliott H. , Wendland Rion , Allen Brittany N. , Worthington Kristan S. , Mullins Robert F. , Stone Edwin M. , Tucker Budd A.
Published: June 2022

Loss of photoreceptor cells is a primary feature of inherited retinal degenerative disorders including age-related macular degeneration and retinitis pigmentosa. To restore vision in affected patients, photoreceptor cell replacement will be required. The ideal donor cells for this application are induced pluripotent stem cells (iPSCs) because they can be derived from and transplanted into the same patient obviating the need for long-term immunosuppression. A major limitation for retinal cell replacement therapy is donor cell loss associated with simple methods of cell delivery such as subretinal injections of bolus cell suspensions. Transplantation with supportive biomaterials can help maintain cellular integrity, increase cell survival, and encourage proper cellular alignment and improve integration with the host retina. Using a pig model of retinal degeneration, we recently demonstrated that polycaprolactone (PCL) scaffolds fabricated with two photon lithography have excellent local and systemic tolerability. In this study, we describe rapid photopolymerization-mediated production of PCL-based bioabsorbable scaffolds, a technique for loading iPSC-derived retinal progenitor cells onto the scaffold, methods of surgical transplantation in an immunocompromised rat model and tolerability of the subretinal grafts at 1, 3, and 6 months of follow-up ( n = 150). We observed no local or systemic toxicity, nor did we observe any tumor formation despite extensive clinical evaluation, clinical chemistry, hematology, gross tissue examination and detailed histopathology. Demonstrating the local and systemic compatibility of biodegradable scaffolds carrying human iPSC-derived retinal progenitor cells is an important step toward clinical safety trials of this approach in humans.
Improved thermal conductivity of epoxy composites via linked boron nitride nanosheets with in-situ generated silver nanoparticles
Authors: Yang Liyi , Zheng Minmin , Ge Fan , Ma Hui , Wang Wei
Published: June 2022

Thermal management plays an important role in electrical and electronic systems. Owing to both excellent thermal conduction and electrical insulation, boron nitride nanosheets (BNNSs) are particularly attractive as fillers in polymer composites. While the thermal properties rely on the connection of BNNSs in polymer matrices significantly. Herein, BNNSs absorbed with silver acetate and 2-ethyl-4-methylimidazole (Ag (2E4MI)2Ac) complex were prepared as thermal conductive fillers for epoxy resin. During the cure of matrix, nano silver ions were in-situ reduced, sintered and bridged individual BNNSs together. Therefore, thermal contact resistance between BNNSs decreased and thermal conducting networks were effectively constructed. The thermal conductivity increased from 1.26 W/mK for the composites only with BNNSs to 2.35 W/mK for the composites with BNNS/[Ag (2E4MI)2Ac] hybrids at 20 vol% BNNSs content. Fitting the measured thermal conductivity results indicated that the thermal contact resistance between fillers decreased with the connections by sintered silver. In addition, the electrically insulating properties of the composites were well preserved and the tensile strength of the composites containing sintered silver interconnects was obviously improved.
Applications of the integral equation method on nonlinear multi degree of freedom vibration systems
Authors: Zhang Wenxin , Chen Yueli
Published: June 2022

This paper compares the accuracy of the integral equation method and the multiple scales method in solving the amplitude equation of multi degree of freedom nonlinear vibration systems. We consider three examples: a two-degree-of-freedom stainless-steel beam system controlled by a saturation controller, a three-degree-of-freedom rotating compressor blade model and a four-degree-of-freedom horizontally supported Jeffcott-rotor system controlled by a PPF controller. The amplitude equations are obtained by applying the integral equation method and the method of multiple scales. The stability analysis is achieved based on the Floquet theory together with Routh–Hurwitz criterion. Furthermore, we modified the iterative procedure of the integral equation method to make the analytic approximate solution more accurate. Finally, the analyses show that in most cases, the analytical solutions obtained by the integral equation method are more excellent agreement with the numerical solutions than the most commonly used method of multiple scales. Therefore, the integral equation method is worth popularizing to obtain the approximate analytical solutions of the multi-degree-of-freedom nonlinear vibration system.
Global finite-time control for image-based visual servoing of quadrotor using backstepping method
Authors: He Wei , Yuan Liang
Published: June 2022

The main objective of this paper is to use a novel finite-time control method to solve the global finite-time convergence problem of image-based visual servoing of a quadrotor Unmanned Aerial Vehicle (QUAV). The effects of external wind resistance and system uncertainty are considered in the QUAV dynamics, and a disturbance observer is used to compensate for these effects. For the problem of obtaining target feature depth information, a novel nonlinear finite-time linear velocity observer is proposed by using the backstepping method. Based on the above two observers, we use the backstepping method to design the global finite-time controller of the system. The system is proved global finite-time stable using the Lyapunov method. Finally, numerical simulation and ROS gazebo simulation results demonstrate the effectiveness of the proposed control scheme.
Alpha-chloralose poisoning in cats: clinical findings in 25 confirmed and 78 suspected cases
Authors: Tegner Cecilia , Lundgren Sandra , Dreimanis Kristoffer , Åberg Annica Tevell , Windahl Ulrika
Published: June 2022

Objectives

The aim of this study was to describe the clinical picture in cats with alpha-chloralose (AC) intoxication and to confirm AC in serum from suspected cases of AC poisoning.

Methods

Suspected cases of AC poisoning were identified in patient records from a small animal university hospital from January 2014 to February 2020. Clinical signs of intoxication described in respective records were compiled, the cats were graded into four intoxication severity scores and hospitalisation time and mortality were recorded. Surplus serum from select cases in late 2019 and early 2020 was analysed to detect AC with a quantitative ultra-high performance liquid chromatography tandem mass spectrometry analysis, and the AC concentration was compared with the respective cat’s intoxication severity score.

Results

Serum from 25 cats was available for analysis and AC poisoning was confirmed in all. Additionally, 78 cats with a clinical suspicion of AC intoxication were identified in the patient records, most of which presented from September to April. The most common signs of intoxication were ataxia, tremors, cranial nerve deficits and hyperaesthesia. The prevalence of clinical signs and intoxication severity differed from what has previously been reported, with our population presenting with less severe signs and no deaths due to intoxication. The majority had a hospitalisation time <48 h, irrespective of intoxication severity score.

Conclusions and relevance

This study describes the clinical signs and prognosis in feline AC intoxication. There were no mortalities in confirmed cases, indicating that AC-poisoned cats have an excellent prognosis when treated in a timely manner. Recognition of AC intoxication as a differential diagnosis for acute onset of the described neurological signs in areas where AC exposure is possible may influence clinical decision-making and help avoid excessive diagnostic procedures. A severe clinical picture upon presentation could be misinterpreted as a grave prognosis and awareness about AC poisoning may avoid unnecessary euthanasia.
Rest-Activity Rhythm Fragmentation and Weaker Circadian Strength Are Associated With Cognitive Impairment in Survivors of Acute Respiratory Failure
Authors: Yang Pei-Lin , Chaytor Naomi S. , Burr Robert L. , Kapur Vishesh K. , McCurry Susan M. , Vitiello Michael V. , Hough Catherine L. , Parsons Elizabeth C.
Published: June 2022

Background: Survivors of acute respiratory failure (ARF) experience long-term cognitive impairment and circadian rhythm disturbance after hospital discharge. Although prior studies in aging and neurodegenerative diseases indicate actigraphy-estimated rest-activity circadian rhythm disturbances are risk factors for cognitive impairment, it is unclear if this applies to ARF survivors. This study explored the relationships of actigraphy-estimated rest-activity circadian rhythms with cognitive functioning in ARF survivors at 3 months after discharge. Methods: 13 ARF survivors (mean age 51 years and 69% males) completed actigraphy and sleep diaries for 9 days, followed by at-home neuropsychological assessment. Principal component factor analysis created global cognition and circadian rhythm variables, and these first components were used to examine the global relationships between circadian rhythm and cognitive measure scores. Results: Global circadian function was associated with global cognition function in ARF survivors ( r = .70, p = .024) after adjusting for age, education, and premorbid cognition. Also, greater fragmented rest-activity circadian rhythm (estimated by intradaily variability, r = .85, p = .002), and weaker circadian strength (estimated by amplitude, r = .66, p = .039; relative strength, r = .70, p = .024; 24-h lag serial autocorrelation, r = .67, p = .035), were associated with global cognition and individual cognitive tests. Conclusions: These results suggest circadian rhythm disturbance is associated with poorer global cognition in ARF survivors. Future prospective research with larger samples is needed to confirm these results and increase understanding of the relationship between disrupted circadian rhythms and cognitive impairment among ARF survivors.
“You’re Not Supposed to be on it Forever”: Medications to Treat Opioid Use Disorder (MOUD) Related Stigma Among Drug Treatment Providers and People who Use Opioids
Authors: Dickson-Gomez Julia , Spector Antoinette , Weeks Margaret , Galletly Carol , McDonald Madelyn , Green Montaque Helena Danielle
Published: June 2022

Opioid use disorder (OUD) through prescription opioid misuse, heroin, and illicitly manufactured fentanyl use has increased dramatically in the past 20 years. Medications to treat opioid use disorder (MOUD) is considered the gold standard for treating opioid use disorders but uptake remains low. Recently, Madden has argued that in addition to the stigma assigned to substance use and people with SUD, MOUDs also are stigmatized, a process she labels intervention stigma to distinguish it from condition stigma (ie, stigma of SUD) . In this paper, we examine MOUD related stigma from the perspective of people who use opioids (PWUO) and key informants who play some role in providing or referring people to drug treatment. Providers and PWOU often viewed MOUD as one drug replacing another which discouraged providers from recommending and PWUO from accepting MOUD. MOUD stigma was also expressed by providers’ exaggerated fear of MOUD diversion. The extent to which MOUD was accepted as a legitimate treatment varied and influenced treatment providers’ perceptions of the goals of drug treatment and the length of time that MOUD should be used with many feeling that MOUD should only be used as a temporary tool while PWOU work on other treatment goals. This led to tapering off of MOUD after some time in treatment. Some providers also expressed mistrust of MOUD stemming from their previous experiences with the over-prescription of opioids for pain which led to the current crisis. Results from this study suggest that the proportion of PWUO on MOUD is unlikely to increase without addressing MOUD stigma among drug treatment providers and PWUO seeking treatment.
Evolving Evidence for the Optimization of Neoadjuvant Therapy in Triple-Negative Breast Cancer
Authors: Silva Diogo , Mesquita Alexandra
Published: June 2022

Representing 15% to 20% of all invasive breast cancers, adjuvant systemic treatment for early-stage, high-risk triple-negative breast cancer (TNBC) is preferentially done in the neoadjuvant setting based on a chemotherapy backbone of anthracyclines and taxanes. Pathological complete response to neoadjuvant treatment constitutes the main objective, regarding its correlation with oncological outcomes. The optimal neoadjuvant regimen to achieve the highest rates of pathological complete response is still under investigation, with the increasing knowledge on the molecular pathways, genomic sequencing, and immunological profile of TNBC allowing for the development of a wide array of new therapeutic options. This review aims to summarize the current evidence and ongoing clinical trials of new therapeutic options for the neoadjuvant treatment of TNBC patients.