bluuebunny/crossref_metadata_2025 huggingface dataset:
Epidemiological study on COVID-19 virus transmission network in northeast China
Authors: Feng Tianyu , Sun Helin , Sun Mengzi , Wang Yudan , Zhang He , Sun Chong , Li Kexin , Wang Yingshuang , Chai Ruiyu , Zheng Pingping , Chen Yang , Pan Pan , Bi Chunli , Zhang Yulong , Yao Yan , Liu Siyu
Published: March 2020

Objective: to analyze the epidemic situation of COVID-19 in northeast China, Liaoning and Jilin. To study the prevalence of COVID-19 virus in areas other than Hubei province. To understand the spread of COVID-19 in Liaoning and Jilin provinces by means of communication network. More in-depth understanding of COVID-19 epidemic, and put forward effective prevention and control recommendations. Methods: We collected the demographic characteristics, exposure history and course of action of patients with laboratory-confirmed infection with COVID-19 published by Liaoning Provincial Health Commission and Jilin Provincial Health Commission as of February 15, 2020. We describe the demographic characteristics, case characteristics, spatial distribution characteristics and related interpersonal network of these patients. To analyze the transmission of COVID-19 in two provinces. Results: By February 15, 2020, the cumulative number of infected people in Liaoning province was 119.The largest number was 27(22.7%) in Shenyang and the smallest in Fushun, with no reported cases of infection. Among them, 55(46.2%) have a history of sojourning in Hubei province. The mainly clinical symptoms of the infected patients were fever, and 67(56.3%) of them developed fever at the time of diagnosis. Cough, sneezing and other respiratory symptoms are less. The cumulative number of infected people in Jilin province was 89, with the highest number in Changchun city at 39(43.8%) and the lowest in Baishan city, with no reported infections. 21(23.6%) people with a history of sojourning in Hubei province. Most of those infected in the two provinces were related to Hubei province, and most of those infected in the second generation or more were infected by close contact with relatives. Conclusion: The COVID-19 outbreaks in Liaoning and Jilin provinces are gradually stabilizing, but have not yet reached the time required to lower the prevention and control level. The fatality rate of the two provinces is relatively low. There is no evidence of super-spreader in either province.
Anemia and its association with Helicobacter pylori infection among adult dyspeptic patients attending Wachemo University Nigist Eleni Mohammad memorial Referral Hospital, Southwest Ethiopia
Authors: Haile Kassahun Tassow , Wolde Deneke , Tesfaye Girum , Yemane Tilahun , Timerga Abebe , Haile Admasu
Published: March 2020

Background: Anemia is a worldwide public health problem and also associated with H. pylori infection. Determining the association of anemia with H. pylori infection is important to develop evidence-based decision and intervention strategies. Association between anemia and H. pylori infection is not well known in Ethiopia. Thus, this study aimed to determine the association between anemia and H. pylori infection among adult dyspeptic patients attending Wachemo University Nigist Eleni Mohammad Memorial Referral Hospital in southwest Ethiopia.Method: A cross-sectional study was conducted from January to April 2019 involving 362 consecutive adult dyspeptic patients who came to the hospital during the study period. Socio-demographic, clinical and other related data were collected by structured questionnaires. Four milliliters of the venous blood sample was collected for hematological parameters analysis and blood film preparation. A stool sample was collected to detect H. pylori antigen and intestinal parasites. Data were analyzed by SPSS version 21. Logistic regression analyses were performed and p-value <0.05 was considered as statistically significant.Results: The overall prevalence of anemia among dyspeptic patients was 24.3% (95%CI: 19.9- 28.7). Among H.pylori infected participants 29.2% were anemic, of which 69.2% had mild anemia and 63.5% had normocytic normochromic anemia. Rural residence (AOR: 1.9, 95%CI: 1.1-3.3), H. pylori infection (AOR: 1.77, 95%CI: 1.05-2.98) and intestinal parasitic infection (AOR: 2.14, 95%CI: 1.14-4.03) were significantly associated with anemia.Conclusion: The prevalence of anemia in this study indicated that it is a moderate public health problem. Rural residence, H. pylori and intestinal parasitic infection were significantly associated with anemia. The findings of this study should be taken into account for the prevention and control of anemia among dyspeptic adults.
Characterizing glycosyltransferases by a combination of sequencing platforms applied to the leaf tissues of Stevia rebaudian
Authors: Zhang Shaoshan , Liu Qiong , Lyu Chengcheng , Chen Jinsong , Xiao Renfeng , Chen Jingtian , Yang Yunshu , Zhang Huihui , Hou Kai , Wu Wei
Published: March 2020

Background: Stevia rebaudiana (Bertoni) is considered one of the most valuable plants because of the steviol glycosides (SGs) that can be extracted from its leaves. Glycosyltransferases (GTs), which can transfer sugar moieties from activated sugar donors onto saccharide and nonsaccharide acceptors, are widely distributed in the genome of S. rebaudiana and play important roles in the synthesis of steviol glycosides. Results: Six stevia genotypes with significantly different concentrations of SGs were obtained by induction through various mutagenic methods, and the contents of seven glycosides (stevioboside, Reb B, ST, Reb A, Reb F, Reb D and Reb M) in their leaves were considerably different. Then, NGS and single-molecule real-time (SMRT) sequencing were combined to analyse leaf tissue from these six different genotypes to generate a more complete and correct full-length transcriptome of S. rebaudiana. Two phylogenetic trees of glycosyltransferases (SrUGTs) were constructed by the neighbour-joining method and successfully predicted the functions of SrUGTs involved in SG biosynthesis. With further insight into glycosyltransferases (SrUGTs) involved in SG biosynthesis, the weighted gene co-expression network analysis (WGCNA) method was used to characterize the relationships between SrUGTs and SGs, and forty-four potential SrUGTs were finally obtained. Of these potential SrUGTs, twenty-seven have complete ORFs and have not been verified to date, and enzyme assays were subsequently performed, but none of them had activity towards SGs. In addition, SrUGT (SrUGT88B1-1) could utilize UDP-glucose as a sugar donor to glycosylate isoquercetin to form three products containing one, two, and three glucoses, respectively.Conclusion: Combined with the results obtained by previous studies and those of this work, we systematically characterized glycosyltransferases in S. rebaudiana and confirmed that four enzymes (SrUGT85C2, SrUGT74G1, SrUGT76G1 and SrUGT91D2) are primarily involved in the glycosylation of steviol glucosides. Moreover, the complete and correct full-length transcriptome obtained in this study will provide valuable support for further research investigating S. rebaudiana.
Comparisons of Five Equations Used for Estimating the Glomerular Filtrations Rate in Chinese Adults
Authors: fu shuai , Yang Min , Xu Si , Wu Sha , Xiao Xiao , Hu Yugang , Li Xiaoning
Published: March 2020

Background We aimed to assess the performance of revised MDRD, CKD-EPI, BIS, FAS and XiangYa equation in Chinese adults Methods We collected blood biochemical data of 623 chinese adult hospitalised patients within 48 hours before they underwent 99m Tc-DTPA GFR measurement. We computed the bias (mGFR-eGFR), the precision (IQR) ,the accuray (P30）and root mean square error (RMSE) relative to mGFR of each equation to evaluate performance. The ROC curves, Kappa value of McNemar test, Bland-Altman plot and the Intraclass correlation coefficient (ICC) were used to evaluate diagnostic accuracy and concordance. Results Totally, the FAS combined Scr and cysC equation performed supreme accuracy(P30=57.5%, RMSE=19.26), the cysC-based equation performed superior to Scr-based equation. Detailed P30 of the CKD-EPI cysC , FAS cysC , MDRD, CKD-EPI Scr-cysC , CKD-EPI Scr , FAS Scr , XiangYa was 56.7%, 56.0%, 53.5%, 52.2%, 48.8%, 51.4%, 43.0%. The CKD-EPI cysC equation showed the lowest bias and the highest accuracy(bias=-2.23, P30=57.4%) in GFR<60ml/min/1.73m 2 , followed by the FASscr-cysC equation(bias=-6.89, P30=55.4%). The XiangYa equation perfomed best in GFR≥60ml/min/1.73m 2 while worst in GFR<60 ml/min/1.73m 2 with bias(-5.79 vs -19.05), IQR(18.21 vs 10.85), P30(86.2% vs 21.1%), RMSE(16.68 vs 21.34). The CKD-EPI cysC equation had the lowest bias and the best accuracy(bias=-2.23, P30=59.4%) in age ≥70 years adults, followed by the FAS Scr-cysC equation equivalented to BIS-2 Scr-cysC equation(bias -5.33 vs -4.90, P30=57.3%), while the XiangYa equation performed worstly (bias=-20.39, P30=26.6%). Best ROC AUC was gaven by the FAS Scr-cysC equation(0.951),so was it had the highest Kappa value(0.364). The lowest Bias showed in Bland-Altman plot was the CKD-EPI cysC equation(bias=7.46). The highest ICC value was gaven by the FAS Scr-cysC equation(0.921). Secondly, it was the XiangYa equation with the ICC of 0.912. Conclusions The FAS Scr-cysC equation is verified most suitable and simpler applied to Chinese population. The CKD-EPI cysC equation is appropriate used in moderately and severely injured GFR(CKD3-5stage) and Seniors over 70 years old. The XiangYa equation performed perfectly in slightly injured GFR (CKD1-2stage), while further verification of XiangYa equation in multiple region need to carried out especially in moderately and severely injured GFR and older adults.
An assessment of sensitivity biomarkers for urinary cadmium burden
Authors: Li Yuting , Wang Hongmei , Yu Jie , Yan Qiong , Hu Honggang , Zhang Lishu , Tian Tian , Peng Xianglei , Yang Shuo , Ke Shen
Published: March 2020

Background Excess cadmium (Cd) intake poses a general risk to health and to the kidneys in particular. Among indices of renal dysfunction under Cd burden measures are the urinary N-acetyl-β-D-glucosidase (UNAG) and urinary β 2 -microglobulin (Uβ 2 -MG) enzymes. However, the end-pointed values and the Cd burden threshold remain controversial because the scopes fluctuate widely. Methods To ascertain the clinical benchmark dose of urinary Cd (UCd) burden for renal dysfunction, 1595 residents near a Cd site were surveyed. Urine was sampled and assayed. A benchmark dose low (BMDL) was obtained by fitting UCd levels and index levels. Results We found that over 50% of the subjects were suffering from Cd exposure as their UCd levels far exceeded the national standard threshold of 5.000 μg/g creatinine (cr). Further analysis indicated that Uβ 2 -MG was more sensitive than UNAG for renal dysfunction. The BMDL for UCd was estimated as 3.486 U/g cr (male, where U is unit of enzyme) and 2.998 U/g cr (female) for UNAG. The BMDL for Uβ 2 -MG, which is released into urine from glomerulus after Cd exposure, was found to be 2.506 μg/g cr (male, where μg is the unit of microglobulin) and 2.236 μg/g cr (female). Conclusions Uβ 2 -MG is recommended as the sensitivity index for renal dysfunction, with 2.2 μg/g cr as the threshold for clinical diagnosis. Our findings suggest that Uβ 2 -MG is the better biomarker for exposure to Cd.
Simethicone administration improves efficacy and efficiency of esophagogastroduodenoscopy
Authors: Sun Xiaotian , Xu Yang , Zhang Xueting , Ma Cuiyun , Li Aitong , Yu Haiyan , Zhang Weihua , Zhang Hanqing , Yang Teng , Zu Shengzhou , Liu Yan , LU Zheng
Published: March 2020

Background: Esophagogastroduodenoscopy is very useful in diagnosing and treating upper gastrointestinal mucosal disorders, but too much foam and water in stomach decrease its diagnostic efficiency. Simethicone administration can help remove excessive foam. Aims: To determine the optimal simethicone administration strategies in a comparative randomized controlled clinical trial.Methods: Adult outpatients with indications for esophagogastroduodenoscopy were enrolled and randomly divided into Group 1 (simethicone solution intake 20-30 min before procedure, n=110), Group 2 (simethicone solution intake 31-60 min before procedure, n=92) and Group 3 (simethicone solution intake >60 min before procedure). Primary and secondary outcome were procedure time and the patients' satisfaction after the examination. All symptoms like abdominal pain, distension were recorded.Results: No statistically significant differences were found on the patients’ demographic and clinical features, and mean examination time (all P values >0.05). The distribution of patients with different endoscopic and pathological diagnosis was comparable among three groups, respectively (P=0.607; P=0.289). However, the proportion of patients with Gastric Cleanness Grade A was most in Group 2 (n=73, 79.3%), and patient proportion with Gastric Cleanness Grade C was most found in Group 1 (n=72, 65.5%), which was greatly different (P<0.001). There was no statistically significant difference on the satisfaction scores [immediately 6 (3-8) vs. 6 (1-10) vs. 6 (1-9), P=0.533; 2h after 10 (8-10) vs. 10 (10-10) vs. 10 (8-10), P=0.463].Conclusion: Simethicone solution intake 31-60 min before esophagogastroduodenoscopy can help obtain best gastric cleanness, which is recommended in clinical practice (registered at ClinicalTrials.gov, NCT03776916).
The role of empowerment in the use of modern contraceptives among women in need of family planning in Burkina Faso: A multilevel analysis
Authors: SOME Sylvain Y. M. , Pu Christy , Huang Song-Lih
Published: March 2020

Background

In Burkina Faso, women still have difficulty satisfying their family planning demand because of the patriarchal and gender-unequal society. Despite evidence that women’s empowerment can help, few studies have measured its impact at both community and household levels. Taking into account these two parameters, we looked into the association between women’s empowerment and modern contraception use among Married Women of Reproductive Age (MWRA) with no desire for having children in Burkina Faso.

Methods

Using the 2010 Demographic and Health Survey (DHS), we analyzed data from 4714 MWRA with family planning needs from 573 communities. Indicators of gender equality at the community level were composed of aggregated variables for each primary sampling unit, and domains of women’s agency in households matters were derived with principal component analysis. A multilevel logistic regression model was used to gauge the effects of empowerment on modern contraceptives use adjusted for household socioeconomic status and demographics of women.

Results

Among MWRA, 30.8% satisfied their demand for family planning using modern methods. At the community level, higher women’s assets ownership (aOR 1.26, CI 1.04 - 1.54), secondary education (aOR 1.45, OR 1.08 - 1.64), and exposure to family planning messages (aOR 1.33, CI 1.08 - 1.64) were associated with more modern contraceptive use; higher ideal number of children was negatively associated (aOR 0.76, CI 0.61 - 0.95). Unexpectedly, higher community prevalence of female genital mutilation was positively associated with contraceptive use (aOR 1.25, CI 1.03-1.52). Women’s agency in household matters, including opposing domestic violence, involved with decisions and enjoying freedom in seeking healthcare were positively associated with use, but only the last domain remained significant in multilevel analysis (aOR 1.29, CI 1.08 - 1.54). Living in richer household, being older, and having secondary education level were also positively associated with modern contraceptive use.

Conclusion

Gender equality at the community level and women’s situation in the household constitute the context in which women’s demand for family planning is determined. Therefore, promoting gender equality and ensuring women’s entitlement to make life choices have the potential to increase modern contraceptive coverage along with improved life conditions.
Transcriptomic analysis of Bursaphelenchus xylophilus treated by a potential phytonematicide, punicalagin
Authors: Guo Qun-Qun , Du Gui-Cai , Zhang Ting-Ting , Wang Mei-Juan , Wang Chao , Qi Hong-Tao , Li Rong-Gui
Published: March 2020

Punicalagin showed significant nematotoxic activity against pine wood nematode (PWN), Bursaphelenchus xylophilus, in the authors’ previous research. The authors performed high-throughput transcriptomic sequencing of punicalagin-treated nematodes to generate clues for its nematotoxic mechanism of action. The authors identified 2,575 differentially expressed genes, 1,428 of which were up-regulated and 1,147 down-regulated. Based on a comprehensive functional in silico analysis, the authors speculate that PWN may respond to the stimulus of punicalagin through phagosome, endocytosis, peroxisome and MAPK signaling pathways. In addition, punicalagin could greatly affect PWN energy metabolism including oxidative phosphorylation. The genes encoding twitchin and a nematode cuticular collagen could be crucial regulation targets of punicalagin, which might contribute to its nematotoxic activity against PWN.
Parental internalizing symptoms as predictors of anxiety symptoms in clinic-referred children
Authors: Fjermestad Krister Westlye , Lium Christina , Heiervang Einar R. , Havik Odd E. , Mowatt Haugland Bente Storm , Bjelland Ingvar , Henningsen Wergeland Gro Janne
Published: March 2020

Background:

Mothers’ and fathers’ internalizing symptoms may influence children’s anxiety symptoms differently.

Objective:

To explore the relationship between parental internalizing symptoms and children’s anxiety symptoms in a clinical sample of children with anxiety disorders.

Method:

The sample was recruited through community mental health clinics for a randomized controlled anxiety treatment trial. At pre-intervention, children (n = 182), mothers (n = 165), and fathers (n = 72) reported children’s anxiety symptoms. Mothers and fathers also reported their own internalizing symptoms. The children were aged 8 to 15 years (M
age = 11.5 years, SD = 2.1, 52.2% girls) and all had a diagnosis of separation anxiety, social phobia, and/or generalized anxiety disorder. We examined parental internalizing symptoms as predictors of child anxiety symptoms in multiple regression models.

Results:

Both mother and father rated internalizing symptoms predicted children’s self-rated anxiety levels (adj. R
2 = 22.0%). Mother-rated internalizing symptoms predicted mother-rated anxiety symptoms in children (adj. R
2 = 7.0%). Father-rated internalizing symptoms did not predict father-rated anxiety in children.

Conclusions:

Clinicians should incorporate parental level of internalizing symptoms in their case conceptualizations.
Procesos de reparación, entre la reparación estatal y la recuperación comunitaria
Authors: Cardona Berrio Natalia Andrea , Arroyave Álvarez Orlando , Ramírez Luis
Published: March 2020

Este artículo analiza las experiencias en torno al daño y la reparación de la comunidad ubicada en la vereda Palmirita del municipio de Cocorná, oriente del departamento de Antioquia (del noroeste de Colombia), que padeció múltiples violencias de los grupos armados, guerrilla, paramilitares y Ejército. Para el análisis se tuvo en cuenta tanto referentes teóricos y legales como a la comunidad. El análisis muestra que el proceso administrativo y jurídico denominado reparación integral, tal como se lleva a cabo, se contrapone en unas ocasiones y en otras se queda corto frente a la visión y expectativas de la comunidad sobre su proceso de reparación, la cual busca recuperar sus espacios relacionales y vitales perdidos por el desplazamiento y otros hechos victimizantes ocurridos en el marco del conflicto armado colombiano.
Tulio Bayer, memoria de un revolucionario o el surgimiento de un nuevo tipo de rebelde en Colombia
Authors: Acevedo Tarazona Álvaro , Lagos Cortés Emilio
Published: March 2020

Entre 1959 y 1964 operaron grupos de guerrilleros colombianos que fueron estimulados por el triunfo de la Revolución cubana, estos serían antecesores de las guerrillas que luego de 1964 se consolidaron en el país; con ellos se inició una nueva etapa de la violencia en la que el protagonismo lo asumieron jóvenes estudiantes y profesionales que buscaban trasformar la estructura de la sociedad para superar la desigualdad social. Entre ellos destaca la figura de Tulio Bayer Jaramillo, cuya trayectoria vital ejemplifica la de los jóvenes de su generación que vieron la lucha armada como el mecanismo para hacer la revolución.
Del prestigio al indicador
Authors: Borja Bedoya Eulalia , Insuasty Rodriguez Alfonso
Published: March 2020

Aumenta así la presión por publicar pero en formatos definidos, estandarizados, esto, en tanto se debe publicar en revistas indexadas y sobre todo, indexadas en bases bibliográficas de impacto, este es un sistema que no escapa a la lógica capitalista monopolizadora que viene impactando directamente el quehacer investigativo universitario, el imaginario de prestigio y la construcción de conocimiento ubicado y de sentido, todo este panorama afecta por supuesto, el Ethos de la ciencia.
Por la vida, ¿Hasta la vida misma?: Líderes sociales en Riesgo (Colombia)
Authors: Zuluaga Cometa Héctor Alejandro , Insuasty Rodriguez Alfonso
Published: March 2020

No podemos ni debemos ver el crecimiento en la militarización, la criminalización, la eliminación de los movimientos sociales, populares, comunidades afro, indígenas, campesinos, etc., como meros fenómenos desconectados o meramente coyunturales, no podemos verlos de forma aislada, éstos son fenómenos estructurales, intencionados, direccionados, derivados de un modelo impuesto.
The Problems of Islamic Religious Education Teacher for Curriculum Development in Transmigration Area
Authors: Shalihin Rahmat Ryadhush , Widodo Hendro
Published: March 2020

This paper aims to analyze the problematics of teacher  to develop curriculum Islamic Religious Education . This research used qualitative methods and data were gathered from literature reviews, observations, and in-depth interviews from teacher and student. The data analyzed with reduction, presentation, and conclusion. The results of this research revealed that The problems of Islamic education teachers in transmigration areas can be summarized into five things. They are first, they have to deal with active time management Secondary learning, management documents, such as students daily paper sheets, Learning Perfoming Plan / RPP, and other extra tasks from school and headmaster to the teacher for some training. Third, the lack of teaching materials causes. Fourth, the problem of conditional and competency teachers. Fifth, they have passive studentsKeywords: Islamic education; transmigration era, problem teacher; curriculum developmentAbstrakMakalah ini bertujuan untuk menganalisis problematika guru dalam mengembangkan kurikulum Pendidikan Agama Islam. Penelitian ini menggunakan metode kualitatif dan data dikumpulkan dari tinjauan literatur, observasi, dan wawancara mendalam dari guru dan siswa. Data dianalisis dengan reduksi, presentasi, dan kesimpulan. Hasil penelitian ini mengungkapkan bahwa masalah guru pendidikan Islam di daerah transmigrasi dapat diringkas menjadi lima hal. Mereka adalah yang pertama, mereka harus berurusan dengan manajemen waktu aktif Pembelajaran sekunder, dokumen manajemen, seperti kertas harian siswa, Rencana Pembelajaran Perfoming / RPP, dan tugas tambahan lainnya dari sekolah dan kepala sekolah kepada guru untuk beberapa pelatihan. Ketiga, kurangnya bahan ajar menyebabkan. Keempat, masalah guru bersyarat dan kompetensi. Kelima, mereka memiliki siswa pasifKata kunci: pendidikan Islam; era transmigrasi, guru bermasalah; pengembangan kurikulum
Needs Analysis of The Islamic Arabic Material Teaching Based on Communicative for University Students
Authors: Mawanti Dwi
Published: March 2020

Teaching materials are one of the important components needed in the learning process. The Arabic language course program is a compulsory course for second semester students department in Islamic Education (PAI) Walisongo State Islamic University (UIN) Semarang. This study aims to describe the students' needs for communicative Arabic based teaching materials for students department in Islamic education at the Faculty of Tarbiyah and Education (FITK) UIN Walisongo Semarang. The results of this study indicate that 41.56% of students require renewal of Arabic course material developed with communicative principles that contain topics of Islamic education in accordance with the department of Islamic education. these materials include Quran-Hadith, Aqedah, Tafsir, Sufism, Fiqh and Islamic History.. AbstrakBahan ajar adalah salah satu komponen penting yang dibutuhkan dalam proses pembelajaran. Program kursus Bahasa Arab adalah kursus wajib untuk mahasiswa semester dua di jurusan Pendidikan Agama Islam (PAI) Universitas Islam Negeri (UIN) Walisongo Semarang. Penelitian ini bertujuan untuk mendeskripsikan kebutuhan siswa akan bahan ajar Bahasa Arab berbasis komunikatif untuk siswa jurusan pendidikan agama islam di Fakultas Ilmu tarbiyah dan kependidikan (FITK) UIN Walisongo Semarang. Hasil penelitian ini menunjukkan bahwa 41,56% siswa membutuhkan pembaharuan materi kursus bahasa Arab yang dikembangkan dengan prinsip-prinsip komunikatif yang berisi topik-topik pendidikan Islam sesuai dengan departemen pendidikan Islam. bahan-bahan ini termasuk Quran-Hadits, Akidah, Tafsir, Sufisme, Fiqh dan Sejarah Islam.
Ocena efektów kosmetycznych radioterapii interwencyjnej (brachyterapii) w świetle doniesień konferencji ESTRO37.
Authors: Chyrek Artur Jan
Published: March 2020

Na przełomie kwietnia i maja 2018 roku w Barcelonie, w Hiszpanii odbyła się 37 konferencja naukowa Europejskiego Towarzystwa Radioterapii Onkologicznej (ESTRO). W jej trakcie po raz kolejny prezentowany był panel grupy GEC-ESTRO zajmującej się radioterapią interwencyjną (brachyterapią), która polega na bezpośrednim wprowadzeniu izotopu promieniotwórczego w guza lub jego lożę. Artykuł ten ma na celu prezentację doniesień dotyczących efektów kosmetycznych brachyterapii stosowanej u Pacjentów nie tylko po to by wyleczyć nowotwór, ale również by pozwolić na zaoszczędzenie narządów, w których jest on zlokalizowany.
Czy istnieje „najlepszy” sposób kontroli ruchomości oddechowej pacjenta w trakcie radioterapii?; w świetle doniesień konferencyjnych ASTRO 59, San Diego, USA.
Authors: Skrobała Agnieszka
Published: March 2020

Celem niniejszej pracy był przegląd i prezentacja metod służących do kontroli ruchomości oddechowej pacjenta podczas radioterapii. Przegląd oparto o wybrane doniesienia oraz problemy badawcze zaprezentowane podczas dorocznego spotkania ASTRO 59 w San Diego.
KARPAL TÜNEL SENDROMLU HASTALARDA KAS KUVVET VE ENDURANSI ÜST EKSTREMİTE FONKSİYONLARINI ETKİLER Mİ?
Authors: KESKİNÖZ Petek Canova , ERGİN Gülbin , BAKIRHAN Sekan , ÖZDEN Ayşe
Published: March 2020

Amaç:
Karpal Tünel Sendromu (KTS) elde
duyusal ve motor kayıplar ile ortaya çıkan bir tuzak nöropatisidir. KTS ile
hastaların azalan kas kuvvetleri ve enduransları fonksiyonel aktivitelerde
yetersizliklere neden olabilir. Bu
çalışma KTS’li hastalarda kas kuvvet ve enduransının üst ekstremite
fonksiyonelliği üzerine olan etkisini araştırmak amacı ile planlandı.Yöntem:
Çalışmaya KTS tanısı alan 45 hasta (yaş ortalaması 49.44±9.04 yıl) dâhil
edildi.  KTS’li hastaların üst ekstremite
kas enduransı, desteksiz kol testi (1. ve 2. diagonal paternde)  ile, üst ekstremite kas kuvveti Hand Held
Dinamometre ile, kavrama kuvvetleri hand dinamometre, parmak
kavrama kuvveti digital pinçmetre ile, üst ekstremite fonksiyonelliğini
değerlendirmek için ise DASH (Kol, Omuz
ve El Yaralanmaları Anketi) kullanıldı.Sonuçlar:
Hastaların
DASH skorları ile üst ekstremite omuz fleksör, ekstansör, abduktör, eksternal
rotatör, dirsek fleksör-ekstansör, el bileği ekstansör ve tüm pinch kuvvetleri
arasında negatif yönde anlamlı ilişki olduğu belirlendi (p<0,05). Hastaların
DASH skorları ile üst ekstremite desteksiz kol testi (1. ve 2. diagonal
paternde) sonuçları arasında negatif yönde anlamlı ilişki olduğu bulundu (p<0,05).

Tartışma:
Karpal tünel sendromlu hastalarda özellikle azalmış kassal endurans ve kassal
kuvvet üst ekstremite fonksiyonlarında azalmalara neden olmaktadır. Karpal
tünel sendromlu hastalarda ağrı ve benzeri semptomlar ile azalan üst ekstremite
fonksiyonelliğini arttırmak için kassal kuvvetin yanısıra uzun dönemde kassal
endurans egzersizlerinin de fizyoterapi programlarına dahil edilmesi
gerektiğini düşünmekteyiz.Anahtar
sözcükler: Lateral epikondilit, dirsek,
kuvvet, endurans, fonksiyon
EL YARALANMASI OLAN KİŞİLER İŞE GERİ DÖNEBİLİYOR MU?
Authors: SIĞIRTMAÇ İlkem Ceren , ÖKSÜZ Çiğdem
Published: March 2020

Amaç: El yaralanması geçiren kişilerin işe geri dönüş sürecini ve bu süreci etkileyebilecek faktörleri

belirlemekti.

Yöntem: Çalışmaya el yaralanması geçiren 47 kişi katıldı. Bireylerin demografik bilgileri ve yarı

yapılandırılmış görüşme yöntemi kullanılarak işe geri dönüş süreçleri ile ilgili bilgiler kaydedildi.

Ayrıca işe geri dönemeyen kişilerin fonksiyonel kapasitesini belirmek amacı ile Kol, Omuz ve El

Sorunu Anketi değerlendirmesi yapıldı. Görüşmeler yüz yüze veya telefon aracılığı ile tamamlandı.

Sonuçlar: Bireylerin kırk beşi (% 96) işe geri dönerken, iki (% 4) bireyin işe geri dönmediği bulundu.

İşe geri dönen kişilerin yaralanma tipleri, kırık (n=17), yumuşak doku (n=7), sinir yaralanması (n=12)

ve ezilme yaralanması/replantasyon/amputasyon (n=9) olarak sınıflandırıldı. İşe geri dönen kişilerin

işe geri dönüş süresi ortanca değeri 45 gün (IQR=7-60) ve rapor süresi ortanca değeri 45 gün

(IQR=45-90) olarak bulundu. Onbir birey (% 24) iş yerinde yaralanırken, 34 birey (% 76) iş yeri

dışında yaralanmıştı. Otuzdokuz bireyin (% 87) yaralanma öncesi ve sonrası işleri aynıydı. İşe geri

dönen kişiler için cinsiyet, medeni durum, yaralanma yeri, yaralanan taraf el, yaralanma öncesi ve

sonrası iş durumu, işe geri dönüş süresi, rapor süresi, iş performansı ve tatmini karşılaştırmalarında

istatistiksel olarak fark anlamlı bulunamadı (p>0,05). İşe geri dönemeyen iki hastanın, tıbbı ve

hukuki süreçlerinin halen devam etmesi ve fonksiyonel anlamda yeterli olmamaları nedeni ile işe

geri dönmedikleri belirlendi.

Tartışma: El yaralanması geçiren kişilerin yaralanma sonrası işe geri dönüş sürecindeki

problemlerin rapor süresi içerisinde azaldığı ve bu süre sonunda yaralanma tipinden bağımsız

olarak kişilerin büyük bir kısmının işe geri dönebildikleri sonucuna varılmıştır.

Anahtar Kelimeler: İşe Geri Dönüş; El Yaralanmaları; Meslek.
BARES TRADICIONAIS NO RIO DE JANEIRO: A HERANÇA PORTUGUESA NO PATRIMÔNIO CULTURAL CARIOCA
Authors: Costa Amanda Danelli , Augusto Leonardo de Carvalho , Rodrigues Thais Alves Corrêa
Published: March 2020

O presente artigo é um dos primeiros resultados da pesquisa que investiga o bar tradicional como bem cultural carioca. Na pesquisa, além de levantamento bibliográfico sobre o tema, realizaram-se entrevistas nos primeiros doze bares registrados pela Prefeitura do Rio de Janeiro. Para o presente artigo destacamos uma série de análises, a partir das referências bibliográficas, que nos ajudaram a compreender a imigração portuguesa nos séculos XIX e XX como uma influência cultural, que contribuiu definitivamente para a construção dos valores que hoje se reconhecem nos bares tradicionais cariocas, a ponto de elevarem alguns desses bares à patrimônio cultural carioca. No Rio de Janeiro, os bares são lugares que conjugam espaço privado e espaço público, casa e rua, entes vivos da cidade e dos cariocas que experimentam ali momentos de tempo livre e lazer. Nossa principal hipótese é a de que os bares tradicionais se tornaram bens culturais justamente porque sua historicidade e as sociabilidades que ensejam contribuem para a construção e o entendimento do que é a cultura urbana carioca desde o passado até os dias de hoje.
REFLEXÕES SOBRE SABERES NECESSÁRIOS PARA A CRIAÇÃO E COMPARTILHAMENTO DE CONHECIMENTOS DE MULHERES CAMPESINAS EM VALENÇA (BA)
Authors: Castro Neves Rubem , Lícia de Santana Stopilha Ana
Published: March 2020

A proposta deste artigo é refletir sobre os saberes necessários para a criação e compartilhamento de conhecimentos de mulheres Campesinas em Valença (BA). Esta reflexão surge das experiências vivenciadas pelos autores em pesquisa de doutorado, assim como a participação dos mesmos no Projeto de pesquisa e extensão vinculado à Universidade do Estado da Bahia – UNEB, intitulado Maria Camponesa. Os sujeitos da pesquisa são mulheres agricultoras e pescadoras do município de Valença (BA) que manejam seus saberes e práticas para garantir sua sobrevivência e perpetuação, o que revela a relevância de pesquisas dessa natureza. Sendo assim, surgiu o seguinte questionamento: quais os saberes necessários para a criação e o compartilhamento de conhecimentos entre mulheres campesinas? A metodologia utilizada para obtenção dos resultados foi a pesquisa-ação. A coleta de dados realizou-se através de questionários, rodas de conversa, oficinas para diálogo entre saberes e, especialmente, com aplicação de técnicas inerentes ao Diagnóstico Rural Participativo (DRP). Os resultados apontam até o momento que os saberes necessários para criação e difusão do conhecimento entre mulheres do campo, assumindo esse conhecimento como uma inovação, precisam ser difundidos e adotados no sistema social e a sua essência está no conhecimento cristalizado em ações e mudanças de atitudes.
AS RELAÇÕES ENTRE OS ARTESÃOS FILIGRANEIROS DE NATIVIDADE, TOCANTINS E O TURISMO
Authors: Fernandes Bonfim Wátila , Balsan Rosane
Published: March 2020

A cidade de Natividade fica no Tocantins, sendo a primeira localidade tombada pelo Instituto do Patrimônio Histórico e Artístico Nacional (IPHAN) no Estado. Um traço que codifica a cidade, considerada um patrimônio cultural imaterial por seus moradores é a secular fabricação de joias utilizando a técnica da filigrana, que consiste em curvar e trançar fios de ouro ou prata, formando grãos. No que diz respeito ao turismo, ficou descortinada a tendência a visitação às ourivesarias por parte de visitantes que valorizam o turismo cultural. Tal fato mobiliza a economia da cidade e atrai dividendos. O objetivo principal deste trabalho foi investigar como a as joias tradicionais e/ou filigranadas de Natividade marcam a relação da sociedade com o lugar, dinamizando as relações sociais e econômicas das pessoas. A pesquisa está inserida na perspectiva da geografia cultural e teve como principais conceitos abordados: patrimônio, identidade, turismo e o lugar.  No que se refere à metodologia, a pesquisa foi realizada através da abordagem qualitativa bola de neve. No total, entrevistou-se 44 pessoas, entre ourives, ex-ourives, aprendizes, moradores e sujeitos ligados ao turismo local. Fez-se uso também da pesquisa documental. Percebeu-se que passado e presente continuam entrelaçados como tênues fios que dão origem as peças em filigrana, e que essa manifestação artística, além de simbolizar, também fortalece o espaço em que está inserido.
New Contours of Greater Eurasia
Authors: Gligich-Zolotareva M. V.
Published: March 2020

While the European Union is undergoing processes of disintegration like the UK’s withdrawal from its membership, the possible collapse of the UK, budget problems, subsidies decrease, territorial and financial disputes and claims – Eurasian integration is slowly and steadily raising. The principle of “communicating vessels” in the course of integration on the continent works largely due to the fact that the European Union and the Eurasian economic Union are single-order system entities with a similar history. Currently, due to the lack of integration in Europe, the EEU has begun to develop intensively. A Large Eurasian partnership is being formed. It is a network of bilateral and multilateral trade agreements with different depth, speed and level of interaction, with market openness depending on the readiness of a particular national economy to work together. Among the BEP’s principles are voluntary, mutually beneficial, equal rights, transparency, and strict compliance with international law and obligations. Despite of a number of issues, such as strengthening of the opposing Eurasian integration trends, the institutional weakness of supranational bodies, lack of development of a regional segment of the Eurasian integration, the Eurasian Union is the path which allow its members to take a worthy place in the complex world of the XXI century.
The Interaction of GLUT1 and FOXM1 Leads to a Poor Prognosis in Colorectal Cancer
Authors: Kuai Xiao-Yi , Lei Zhi-Yi , Liu Xiao-Shuang , Shao Xin-Yu
Published: March 2020

Background:

Colorectal Cancer (CRC) is one of the most common fatal diseases with high morbidity.
Alteration of glucose metabolism is one of the hallmarks in the development of CRC. Glucose Transporter 1
(GLUT1) is a key rate-limiting protein in hyperactive glucose metabolism and up-regulated in CRC, however, the
underlying mechanism of the altered metabolism in CRC is still unknown.

Methods:

In this study, immunohistochemical staining was used to evaluate the expression of GLUT1 and FOXM1 in
135 paired CRC and adjacent normal tissues. The association between the expression of GLUT1/FOXM1 and clinicopathological
factors was determined and the correlation between GLUT1 and FOXM1 in CRC was investigated.

Results:

Our results revealed that regardless of tumor location, GLUT1 and FOXM1 were overexpressed in CRC
tissues, especially in patients with positive lymph node metastasis and TNM stage III-IV. Furthermore, GLUT1
showed a significantly strong link with FOXM1 in CRC tissue.

Conclusions:

Overexpression of GLUT1 and FOXM1 may play critical roles in CRC leading to a poor prognosis.
PDK1 Inhibitor GSK-470 Exhibits Potent Anticancer Activity in a Pheochromocytoma PC12 Cell Tumor Model via Akt/mTOR Pathway
Authors: Zhang Xiaohua , Zhong Shan
Published: March 2020

Background:

Phosphoinositide-Dependent Kinase 1 (PDK1) is now widely studied in malignant
solid tumors. Researchers have previously revealed that targeting PDK1 is thought of as a promising anticancer
treatment strategy. The aim of this study was designed to evaluate the anticancer activity of GSK-470, a novel
and highly specific inhibitor of PDK1, in Pheochromocytoma (PCC) tumor model.

Methods:

PC12 cells were xenografted into nude mice to build PCC tumor model. Animals were treated with
GSK-470 vs vehicle. Mean tumor volume was calculated and compared across groups. TUNEL was used to
detect apoptosis. The effects of PDK1 inhibitor GSK-470 on activation of the Akt signaling and its downstream
Akt/mTOR pathway in xenotransplant tumor tissues were examined by western bolt.

Results:

The mean tumor volume in GSK-470 group was significantly less than that in control group. TUNEL
results found that cell apoptosis was markedly increased in GSK-470 group compared with the control group.
The western bolt analysis showed that the phosphorylation of Akt at threonine 308 was significantly reduced in
GSK-470 group. Also, GSK-470 strongly inhibited phosphorylation of mTOR on Ser2448, a marker for
mTORC1 activity, as well as phosphorylation of p70S6K, best characterized targets of mTOR.

Conclusion:

Our results showed that GSK-470 exhibited potent anticancer activity in PC12 tumor-bearing mice.
Also, we found that this effect appeared to be mediated by the inhibition of the Akt/mTOR pathway. The present
study once again provides new insights into the therapeutic effects of inhibiting PDK1 in the treatment of malignant
PCC. Therefore, we propose that GSK-470 might be an effective therapeutic agent for the treatment of
malignant PCC.
Evaluation of Anticancer, Antibacterial and Antioxidant Properties of a Medicinally Treasured Fern Tectaria coadunata with its Phytoconstituents Analysis by HR-LCMS
Authors: Reddy Mandadi N. , Adnan Mohd. , Alreshidi Mousa M. , Saeed Mohd. , Patel Mitesh
Published: March 2020

Background:

Tectaria coadunata (T. coadunata) is an important fern species with a number of
medicinal properties. It has been evidently found for its effectiveness in ethanomedicinal usage, which can also
emerge as one of the most promising sources for nutraceuticals.

Objective:

This study aims to examine the phytochemistry of the whole crude extract of T. coadunata for the
first time with evaluation of antibacterial, antioxidant and anticancer activity.

Methods:

High Resolution Liquid Chromatography Mass Spectrometry analysis (HR-LCMS) was performed for
confirming the presence of biologically active constituents in the extract of T. coadunata followed by antibacterial,
antioxidant and anticancer activity.

Results:

With the detailed Mass spectra data, absorbance spectra and retention times, chemical composition of
T. coadunata holds a diverse group of bioactive/chemical components such as sugars, sugar alcohol, flavonoids,
terpenoids and phenolics. The results for antioxidant activity showed that T. coadunata crude extract had higher
scavenging potential against 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals than H2O2 molecules, which
was followed by positive antibacterial activity against several pathogenic bacteria like Shigella flexneri, Staphylococcus
aureus and Salmonella typhi.

Discussion:

The ethanolic extract of T. coadunata showed favorable antiproliferation activity against three
leukemic (KG1, MOLT-3 and K-562) cells in a dose dependent manner, especially for KG1 42.850±1.24μg/ml.

Conclusion:

This study has provided a better understanding of the presence of biologically active phytochemical
constituents in the extract of T. coadunata, which can be the reason for its bioactive potential. Moreover,
T. coadunata has significant anticancer activities against human leukemic cancer cell lines, indicating it as a potential
anticancer agent.
Simultaneous Detection of Drug-resistant Mutations in Mycobacterium tuberculosis and Determining their Role through In Silico Docking
Authors: Nachappa Somanna Ajjamada , Neelambike Sumana M. , Sarikhani Ahmad , Ramachandra Nallur B.
Published: March 2020

:

A molecular method for diagnosis of drug-resistant Tuberculosis is Multiplex allele-specific PCR (MAS-PCR), which is more time-efficient. Also, understanding the role of mutations when translated to protein, in causing resistance helps better drug designing.

Aims:

To study MAS-PCR in the detection of drug resistance in comparison to DNA sequencing, and understand the mechanism of interaction of drugs with mutant proteins in Mycobacterium tuberculosis.

Methods:

Detection of drug-resistant mutations using MAS-PCR and validation through DNA sequencing. MAS-PCR targeted four genes, iniA for the drug Ethambutol, rpsL and rrs for Streptomycin, and gyrA for Fluoroquinolone resistance, respectively. Further, the sequence data was analysed and modelled to study the effect on interaction of the anti-TB drug molecule with the target protein using in silico docking.

Results:

We identified drug-resistant mutations in four out of 95 isolates with one of them carrying a mutation at codon iniA501, two at gyrA94, and one for both iniA501 and gyrA94 using MAS-PCR. DNA sequencing confirmed drug-resistant mutations in only two isolates, whereas two others had mutation adjacent to the target allele. Molecular docking showed Estimated Free Energy of Binding (ΔG) being higher for Fluoroquinolone binding with GyrA D94V mutant. Both, wild and mutant IniA interact with EMB but had no significant effect on binding energy.

Conclusions:

DNA sequencing-based drug resistance detection of TB is more accurate than MAS-PCR. Understanding the role of mutations in influencing the drug-protein interaction will help in designing effective drug alternatives.
Technology Transfer in Poland: Overview
Authors: Jarzynowski Marcin
Published: March 2020

:

The aim of this paper is to give an overview of the current state of
technology transfer in Poland by examining various stages of the process and
indicators associated with different actors involved. In order to examine the role of
technology in polish enterprises, it takes into account different forms of intellectual
property, both created and acquired in Poland. Data taken into consideration
include domestic and external sources, focused on the years 2013 - 2017. The main
sources of the statistics are the Polish Patent Office and the Central Statistics
Office.

:

Phenomena observed in the data are supported and elaborated by domestic research
articles concerned with technology transfer and open innovation. The most striking
feature of such juxtaposition is the fact, that some of the indicators presented in the
article are surprisingly low, considering overall economic situation.

:

All of the above represents the context of the Open Innovation Network project,
which is also presented in the paper. Interpretation of the presented results is
included in the discussion section. Some of the indicators confirm the status of
polish economy as moderately innovative, however trends in performance of a
small group of technical universities show a promising development in the field of
technology transfer.
Faces extracted from Time Magazine 1923-2014
Authors: Jofre Ana , Berardi Vincent , Bennett Carl , Reale Michael , Cole Josh
Published: March 2020

We present metadata of labeled faces extracted from a Time magazine archive that contains 3,389 issues ranging from 1923 to 2012. The data we are publishing consists of three subsets: Dataset 1) the gender labels and image characteristics for each of the 327,322 faces that were automatically-extracted from the entire Time archive, Dataset 2) a subset of 8,789 faces from a sample of 100 issues that were labeled by Amazon Mechanical Turk (AMT) workers according to ten dimensions (including gender) and used as training data to produce Dataset 1, and Dataset 3) the raw data collected from the AMT workers before being processed to produce Dataset 2.
¿Identidades a la medida? (o de cómo entrar y salir de la modernidad por la puerta que más nos guste)
Authors: Camou Antonio
Published: March 2020

¿Identidades a la medida? (o de cómo entrar y salir de la modernidad por la puerta que más nos guste)
Origen, identidad y acción política: reflexiones sobre la vida y obra de Hannah Arendt
Authors: Young-Bruehl Elisabeth , R. Halffter Eva
Published: March 2020

Origen, identidad y acción política: reflexiones sobre la vida y obra de Hannah Arendt
Salvar la vida
Authors: Habichayn Verónica
Published: March 2020

Salvar la vida
Carta abierta a mi nieta o nieto
Authors: Gelman Juan
Published: March 2020

Carta abierta a mi nieta o nieto
El pacto tras las rejas
Authors: Donaldson Stephen , Amador Carlos , Moreno Hortensia
Published: March 2020

El pacto tras las rejas
En Roseau
Authors: Kincaid Jamaica , Amador Carlos , Moreno Hortensia
Published: March 2020

En Roseau
La historia, la memoria y la identidad en los comunicados del EZLN
Authors: Rojo Arias Sofía
Published: March 2020

La historia, la memoria y la identidad en los comunicados del EZLN
El paria
Authors: Clément Catherine , Rojo Arias Sofía
Published: March 2020

El paria
Inés: una metáfora de la libertad y la contaminación
Authors: Gutiérrez de Velasco Luzelena
Published: March 2020

Inés: una metáfora de la libertad y la contaminación
"Rituales": Coatlicue y Coyolxauhqui
Authors: González Lucero
Published: March 2020

"Rituales":Coatlicue y Coyolxauhqui
Emily Dickinson: de la marginación a la automarginación: una metodología para la escritura
Authors: Mayorga Susana , Salzmann Elisa María
Published: March 2020

Emily Dickinson: de la marginación a la automarginación: una metodología para la escritura
Una poética de lo subterráneo: la narrativa de Inés Arredondo
Authors: Martínez-Zalce Graciela
Published: March 2020

Una poética de lo subterráneo: la narrativa de Inés Arredondo
El extraño horizonte de la crítica feminista en Brasil
Authors: Buarque Hollanda Heloisa
Published: March 2020

El extraño horizonte de la crítica feminista en Brasil
La vida cotidiana, el trabajo, la política
Authors: Pérez Francisca
Published: March 2020

La vida cotidiana, el trabajo, la política
Lugar en el gobierno: ¿Alibi o conquista?
Authors: Vargas Elisabeth , Aparecida Schumaher María
Published: March 2020

Lugar en el gobierno: ¿Alibi o conquista?
Articulación y transnacionalización de los feminismos latinoamericanos
Authors: Álvarez Sonia E.
Published: March 2020

Articulación y transnacionalización de los feminismos latinoamericanos