bluuebunny/crossref_metadata_2025 huggingface dataset:
Κοινωνικά προβλήματα, κοινωνική πολιτική και λογοτεχνία (Ντίκενς) στην Βρετανία κατά τον 19ο αιώνα
Authors: Δικαίος Κώστας , Σκαρλατίδου Εύα
Published: February 2018

Το άρθρο αυτό αποσκοπεί στην συσχέτιση της λογοτεχνίας (Ντίκενς) με τα κοινωνικά προβλήματα και την κοινωνική πολιτική στην Βρετανία του 19ου αιώνος. Αρχικά προσεγγίζει το ερώτημα για πολιτικές αναγνώσεις λογοτεχνικών έργων, και κατόπιν παρουσιάζει εν συντομία τον τρόπο με τον οποίο η Αγγλία, αλλά και γενικά Βρετανία, κατόρθωσε να γίνει τόσο ισχυρή μέσα από την παραγωγή και εξαγωγή βαμβακιού. Γίνονται αναφορές στις εφευρέσεις που βοήθησαν στην ταχεία παραγωγή ενώ περιγράφονται οι συνθήκες ζωής και εργασίας των εργατών. Δίνεται έμφαση στους μη προνομιούχους του 19ου αιώνα, φτωχούς και πένητες, παράλληλα πληροφορούμαστε για τις εργασίες που αναγκάζονταν να κάνουν γυναίκες και παιδιά για να μπορέσουν να επιβιώσουν. Επιπλέον, γνωστοποιούνται νόμοι του αιώνα που σκοπό είχαν να βελτιωθεί η ζωή των μη προνομιούχων. Ιδιαίτερη έμφαση δίνεται στα άτομα του 19ου αιώνα που διέφεραν από την πλειονότητα με τις πράξεις τους, και συχνά χαρακτηρίζονταν από τρίτους ως σοσιαλιστές. Κλείνοντας, τονίζεται η προσφορά του Ντίκενς στην κριτική των κοινωνικών και πολιτικών συνθηκών τις εποχής μέσα από τα έργα του αλλά και η επιρροή του σε άλλους λογοτέχνες.
shinySISPA: A web tool for defining sample groups using gene sets from multiple-omics data
Authors: Dwivedi Bhakti , Kowalski Jeanne
Published: February 2018

As opposed to genome-wide testing of several hundreds of thousands of genes on very few samples, gene panels target as few as tens of genes and enable the simultaneous testing of many samples.  For example, some cancer gene panels test for 50 genes that can affect tumor growth and potentially identify treatment options directed against the genetic mutation.  The increasing popularity of gene panel testing has spurred the technological development of panels that test for diverse data types such as expression and mutation.   Once samples are tested, there is the desire to examine clinical associations based on the panel and for this purpose, one would like to identify, among the samples tested, which show support for a molecular profile (e.g., presence of mutation with increased expression) versus those samples that do not among the genes tested.  With user-specified molecular profile of interest, and gene panel data matrices (e.g., gene expression, variants, etc.) that define the profile, shinySISPA (Sample Integrated Set Profile Analysis) is a web-based shiny tool to define two sample groups with and without profile support based on our previously published method from which clinical associations may be readily examined. The shinySISPA can be accessed from http://shinygispa.winship.emory.edu/shinySISPA/.
Real Options Models for Proactive Uncertainty-Reducing Mitigations and Applications in Cybersecurity Investment Decision Making
Authors: Benaroch Michel
Published: February 2018

Managerial flexibility, or real options, embedded in information technology (IT) investments allows resolving uncertainty not only by passively waiting for new information to arrive during deferral but also by proactively deploying mitigations. Classic real options models fail to account for the value of proactive uncertainty-reducing mitigations, since they assume that uncertainty is fixed or follows a continuous, time-dependent dynamics. We present adaptations of these models that address this shortcoming. In our models, zero or more mitigations can be applied in varying sequences, mitigations have impulse-type effects on uncertainty reduction, and mitigations’ effects can be complementary, substitutive, or synergetic. These traits make the value of mitigations path dependent and conditional on the uncertainty-reduction ability of earlier deployed mitigations. We operationalize the effects of mitigations in the IT and cybersecurity investment contexts. We also apply the adapted models to a real-world cybersecurity investment case from a Japanese company. Investments in multiple cybersecurity mitigations are typically treated as having a multiplicative effect that leads to overinvestment in mitigations. Our models avoid this problem, permitting to lower cybersecurity costs without compromising on loss prevention. More generally, our models allow implementing the real options logic more fully by supporting both passive and proactive IT investment risk management.

The online appendix is available at https://doi.org/10.1287/isre.2017.0714 .
A new way of organising palliative care for patients with severe chronic obstructive pulmonary disease
Authors: Lavesen Marie , Marsa Kristoffer Bastrup-Madsen , Bove Dorthe Gaby
Published: February 2018

Patients with chronic obstructive pulmonary disease (COPD) often live with unmet palliative needs and low quality of life, although several guidelines recommend that those with COPD should be offered early and integrated palliative care. However, none of the guidelines describe how these recommendations can be operationalised and the current literature offers little information about experiences with developing and implementing new palliative care services. This article offers insight into the experience of developing and implementing a new palliative outpatient structure for patients with severe COPD. All patients are assigned to a nurse who has overall responsibility for establishing and maintaining an individualised relationship with the patient and identifying their needs for care and treatment. Routine outpatient visits are replaced by ad hoc consultations, and patients are seen by pulmonary specialists only when there is a need for medical assessment and treatment or a planned advanced care planning dialogue. The new service was succesfully implemented; however, the changes required good multidisciplinary collaboration, dedicated health professionals and managerial support. This paper highlights the need for further studies to investigate the effectiveness of new palliative care interventions for patients with COPD.
Lithuanian folk ensembles as bonding social capital: Perspectives on participatory music-making in Vilnius
Authors: Bartolome Sarah J.
Published: February 2018

The purpose of this study was to examine the culture of four Lithuanian folk ensembles with particular attention to the perceived values and benefits for participants and the perceived functions of the ensembles in local and national communities. Based on five months of ethnographic fieldwork in Vilnius, findings suggest a wide range of benefits associated with participation that vary across generations. Folk ensembles emerged as critical to the preservation and dissemination of a living body of folk culture and also serve to cultivate a sense of Lithuanian identity among members. Findings are examined using a social capital framework and the notion of Lithuanian folk ensemble as generators of flexible bonding social capital is forwarded.
Singing and spirituality in a South African male voice group
Authors: Joseph Dawn , Page-Shipp Roy , Niekerk Caroline van
Published: February 2018

Since the mid 1970s, a group of twelve business and professional members of a male singing group have continued singing together in Pretoria, South Africa. These singers were interviewed as part of a project on spirituality and well-being: music in the community. From the interview data, two overarching themes emerged, membership benefits and spiritual connections; these are discussed in this research project. Members’ views of benefits related mainly to fulfilment of personal, including musical, needs, although all were gratified that their singing provided enjoyment to community audiences and benefits to disadvantaged communities, mainly from ticket sale proceeds. Most saw an association between singing and the spiritual, but only a minority identified a religious connotation, the remainder relating to nonreligious factors such as the ‘human spirit’. A deep sense of commitment and a love of music impacts positively on social engagement, benefiting and enhancing quality of life for the group members.
Listen to a Songbird sing: Musicians, creativity and the paediatric hospital setting
Authors: Hawley Ros
Published: February 2018

Music making in a paediatric hospital offers new pathways to communication. Children become the leaders of musical interaction, as musicians carefully observe moods, emotions and the smallest of responses in order to be able to ‘listen’ to and respond to a child. Opportunities for music-making are created by the bedside and on the way to treatment. Medical professionals and families engage with live music and musicians, as a natural part of hospital life. Musical vocabulary is developed between musician and child patient to include music made with breath, mouth sounds, vocalization, hands and fingertips. Sense of time and space expand and contract in moments of music creation. Trust between musicians, patients and staff is gained through carefully paced musical interaction, ensuring a gradual exposure to musicians, live music and shared music-making. Songbirds, a two-year musicians’ residency in a children’s rehabilitation ward enabled children experiencing long-term hospitalization and their families to participate in regular music making sessions with myself and a colleague as part of their process of recovery. Many of the children were non-verbal and music making became an important element in supporting cognitive and social development and in reducing anxiety. In this case study of my practice as a musician working in a hospital I reflect on how the experience of making music with children informs and inspires processes of interaction and creativity, and how observations made during music making influence a musician’s reflection and consolidation of practice.
The performer-creator as collaborator in the music theatre industry: Creative agency versus professional agency
Authors: Walker Jessica
Published: February 2018

This article considers alternative creative, collaborative and professional possibilities for the classically trained singer in current music theatre practice. Through the lens of three self-created, professionally produced music theatre pieces, the article examines the agential development of the performer/creator, both in terms of how creative responsibility intersects with creative agency, and with regard to how external industry factors can influence and affect creative and professional agency.
Music theatre as a ‘fluctuating analytical protocol’ – Daniel Ott and Manos Tsangaris in conversation
Authors: Roesner David
Published: February 2018

The year 2016 marks the beginning of a new era in the history of one of the world’s leading festivals for new music theatre: the Munich Biennale. After Hans-Werner Henze (1988–94) and Peter Ruzicka (1996–2014), it will now be under the new joint artistic leadership of composers Daniel Ott and Manos Tsangaris. Their wide notion of what constitutes ‘music theatre’ and a radical rethinking of the conventions, hierarchies and chronologies of creating new original works forms an integral part of how they seek to innovate the festival and its artistic processes. This conversation seeks to explore their conceptual thinking for the festival and understanding of music theatre that drives them. The interview took place in November 2015, six months ahead of the launch of the Biennale 2016.
The People's Republic of China
Authors: Mugnier Clifford J.
Published: February 2018

The Grids & Datums column has completed an exploration of
every country on the Earth. For those who did not get to enjoy
this world tour the first time, PE&RS is reprinting prior articles
from the column. This month's article on The People's Republic
of China was originally printed in 2000 but contains updates to
their coordinate system since then.
A grande arte de desaparecer: Rubem Fonseca e os documentários do Ipês
Authors: Lísias Ricardo
Published: February 2018

Nos anos que antecederam o golpe militar de 1964, o Instituto de Pesquisas e Estudos Sociais (Ipês) realizou diversas atividades de propaganda com o intuito de desestabilizar o governo de João Goulart e com isso ajudar no estabelecimento de condições que possibilitariam a ruptura democrática. Entre as atividades do instituto estava o financiamento, supervisão de criação e distribuição de uma série de documentários que, exibidos no país inteiro, tinham como intenção propagar a ideologia liberal e, ao mesmo tempo, fortalecer as correntes que queriam, a qualquer custo, a saída de Goulart. A autoria dos roteiros desses documentários é controversa: alguns pesquisadores a atribuem ao escritor Rubem Fonseca, apoiados em alguns documentos e testemunhos, enquanto outros recusam essa hipótese. Algo ainda não realizado é a comparação formal entre os documentários e a obra que Fonseca produziu nesse período. Este ensaio esboça, nos seus limites, uma comparação.Palavras-chave: golpe de 1964; Ipês; Rubem Fonseca.
Pasquins, libelos e panfletos: a cultura do manuscrito na América portuguesa
Authors: Romeiro Adriana
Published: February 2018

Este artigo discute a tradição e a circulação dos pasquins, libelos e panfletos no contexto luso-brasileiro, entre os séculos XVII e XVIII , focalizando o papel que desempenharam na cultura política do período. Forma de expressão privilegiada das crenças e valores políticos, esses manuscritos integraram o amplo repertório das ações políticas em curso no mundo ibérico, ocupando um lugar de destaque nas revoltas e sublevações. Originárias de uma tradição medieval, tais manifestações combinavam elementos das culturas popular e erudita, explorando o humor e a paródia como recursos estilísticos mais comuns. Apresentando-se geralmente como portadores da chamada “voz comum”, eles são fontes valiosas para o estudo das ideias e práticas políticas da época moderna.Palavras-chave: manuscrito; cultura; época moderna.
Tradução em debate: disputas pela história literária de Portugal entre Robert Southey e João Guilherme Cristiano Müller
Authors: Ramos André Da Silva
Published: February 2018

Neste artigo, apresento as disputas pela história literária de Portugal pelos letrados Robert Southey e João Guilherme Cristiano Müller a propósito da tradução de “Extratos em português e em inglês, com as palavras propriamente acentuadas para facilitar o estudo daquela língua”, publicado originalmente por Southey no periódico britânico Quartely Review, em 1809. João Guilherme Cristiano Müller traduziu o texto para o português em 1810, intitulando-o Memória sobre a literatura portuguesa. A partir da análise dos contextos de enunciação de ambos os textos em suas respectivas versões em inglês e português, exploro os horizontes de significação da história literária portuguesa e as disputas políticas, historiográficas e literárias entre os letrados, que enfrentavam o desafio comum da aceleração do tempo histórico e crise das representações em meio às guerras napoleônicas.Palavras-chave: História da historiografia; História de Portugal; tradução.
A obra do entalhador lisboeta Manuel de Brito na Matriz do Pilar em Ouro Preto
Authors: De Oliveira Pedrosa Aziz José
Published: February 2018

Registros históricos balizam a atividade do entalhador Manuel de Brito na produção de dois retábulos da Matriz do Pilar, em Ouro Preto. Acreditase que foi ele o oficial que também faturou, em 1723, o retábulo-mor da igreja lisboeta de São Miguel e que, posteriormente, arrematou serviços de talha na igreja carioca de São Francisco da Penitência. Assim, este texto tem como eixo central o estudo da atuação de Brito no universo da talha luso-brasileira, a delimitação espacial e temporal de seu fazer em Minas Gerais, bem como o exame dos retábulos da Matriz do Pilar em que a documentação especifica seu labor. A partir daí, pretende-se preencher vazios que persistem diante da inexistência de pesquisas e análises acerca das peças retabulares investigadas, em prol de se mensurar a intervenção de Brito e avaliar seu protagonismo na disseminação do repertório joanino na talha colonial setecentista, sobretudo em Minas.Palavras-chave: Manuel de Brito; Minas Gerais; estilo joanino.
Norbert Elias e a história da violência no Brasil
Authors: Carneiro Deivy Ferreira
Published: February 2018

O objetivo deste artigo é discutir, em primeiro lugar, a teoria eliasiana do processo civilizador e seu impacto na diminuição da violência interpessoal na Europa, na longa duração. Em segundo lugar, analisaremos a possibilidade de aplicarmos os insights de Elias para estudarmos o desenvolvimento histórico da violência no Brasil. Para prensarmos tais questões, utilizaremos dois exemplos: um deles macro, que estuda a violência em Minas Gerais de forma quantitativa, e o outro, numa perspectiva micro, que enfatiza a relação cotidiana da população com a justiça.Palavras-chave: Norbert Elias; violência; habitus.
¿Y si pluralizamos lo que entendemos como conocimiento y creación?
Authors: Gómez Moreno Pedro Pablo
Published: February 2018

En los estudios artísticos la concepción de conocimiento está constantemente en juego. En ese sentido, su horizonte posible está directamente relacionado con la tensión que se da entre la idea que tiene la institución del arte sobre el conocer (o las ciencias que permean el campo del arte) y lo que finalmente dicen y hacen los creadores dentro y fuera de las artes. Por lo tanto, las definiciones teóricas e institucionales son interpeladas por las prácticas que en muchos casos hacen que las definiciones parezcan reductoras y precarias.Ahora bien, lejos de estar planteando un dualismo entre teoría y práctica –que fue la base para la clasificación moderna de los seres humanos como pensantes, menos pensantes o carentes de capacidades sensibles y cognitivas– lo que quiero señalar es la dimensión teórica de las prácticas mismas y, en consecuencia, el carácter cognitivo inherente en todas las modalidades del hacer. Y no solo eso, el hacer no es cognitivo porque aplica o replica conocimientos, es cognitivo porque es creador de nuevos conocimientos que se hacen visibles en otros modos de hacer y formas sensibles cada vez más diversas y plurales
La Historia del Arte como libro: definiciones y crisis de un espacio de inscripción
Authors: Cruz Pedroni Juan
Published: February 2018

Como artefacto escrito y visual, el objeto libro tiene un lugar central en la inscripción histórica de la obra de arte. Algunas prácticas artísticas contemporáneas comentan esta centralidad e interpelan el discurso histórico-artístico a través de un uso poético de sus soportes impresos. En el presente trabajo proponemos, en primer lugar, un acercamiento teórico a la disciplina Historia del Arte a través de sus despliegues materiales en el libro, considerada como un dispositivo y un espacio de inscripción que promueve determinados efectos de sentido. A partir de estos aportes teóricos, reflexionamos, en un segundo momento, sobre una serie de prácticas de artistas argentinos en las que el discurso de la Historia del Arte y sus soportes impresos aparecen tematizados. Estas prácticas son interpretadas como síntomas de una crisis de determinadas creencias en torno a la Historia y al libro como espacios de inscripción de lo artístico.
Procesos de comunalización y etnización en la construcción de identidades colectivas de la gente afro del Ecuador
Authors: Santacruz Benavides Lucy
Published: February 2018

En estas páginas presento algunas reflexiones frente a los procesos de construcción de identidades colectivas de las poblaciones afro del norte del Ecuador, mostrando cómo la formación discursiva de las comunas y las etnias expresan representaciones identitarias, resultado de tensiones, negociaciones y posicionamientos políticos de las poblaciones, en su agencia colectiva frente al Estado. Las identidades, serán entonces consideradas como escenarios de lucha, donde se negocian y se intentan subvertir relaciones de poder. Para esto, inicialmente hago referencia a algunos hitos históricos que permiten ubicar el poblamiento afro de Esmeraldas como escenario de resistencia, momentos que van dibujando, a su vez, el lugar de esta zona en el ideario nacional ecuatoriano; posteriormente me refiero a la constitución de la Comuna Rio Santiago Cayapas, para mostrar las maneras particulares como se dio en este escenario lo que llamo proceso de comunalización, y finalmente retomo algunos elementos relevantes frente a la etnización como resultado adelantado por el movimiento afroecuatoriano.
Modeling of Heat Transfer in Rotary Furnaces Using Finite Element Approach
Authors: Akinluwade K. J. , Ibitoye F. P. , Isadare D. A. , Adeoye M. O. , Adetunji A. R.
Published: February 2018

The pattern of heat flow in a 100-kg capacity rotary furnace was studied at transient state using finite element technique. The study combined volumetric analysis of combusting fuel with finite element analytical computation of heat transfer within the furnace hearth. A parabolic partial differential equation was used in combination with the results of volumetric analysis of combusting fuel, which is applicable to transient heat transfer. The results provide a finite element approach to computational modeling of medium-sized diesel-fired melting furnaces in the metallurgical industry.
Psychopathy and Internalizing Psychopathology: A Triarchic Model Perspective
Authors: Latzman Robert D. , Palumbo Isabella M. , Sauvigné Katheryn C. , Hecht Lisa K. , Lilienfeld Scott O. , Patrick Christopher J.
Published: February 2018

Methodological and conceptual differences across studies have impeded our understanding of the relationship between psychopathy and internalizing psychopathology. To shed further light on this question, we undertook correlational and structural-modeling analyses of data from two samples to characterize how facets of psychopathy relate to internalizing psychopathology when assessed using multidimensional measures of each construct (i.e., Triarchic Psychopathy Measure, Inventory of Depression and Anxiety Symptoms). Participants for Study 1 were 470 undergraduates and community-dwelling adults who completed these measures in self-report form; participants for Study 2 were 301 community-dwelling adults who completed informant-rating versions of these measures (as applied to a known-other). Across samples, analyses revealed sharply contrasting associations for the three triarchic-model facets with internalizing psychopathology and its subdomains, with boldness relating negatively in most cases, disinhibition relating positively in most cases, and meanness exhibiting mostly null associations. Results provide a nuanced picture of associations between psychopathic symptomatology and internalizing problems.
TIBBİ VE AROMATİK BİTKİLERİN KULLANIMI İLE EKMEĞİN FENOLİK MADDE İÇERİĞİNİN ZENGİNLEŞTİRİLMESİ
Authors: Arslan Burnaz Nesibe , Hendek Ertop Müge , Karataş Şeyda Merve
Published: February 2018

Son yıllarda, tüketicilerin fonksiyonel gıdalara ilgisi artmaktadır.
Bunun temel nedeni, fonksiyonel gıdaların içerdikleri fenolik bileşikler ve
doğal antioksidanlarla insan sağlığı üzerine olumlu etkilerinin bulunmasıdır.
Bu amaçla pek çok zenginleştirilmiş ürün formülasyonu geliştirilmektedir.
Özellikle günlük diyette her öğünde sofralarda yerini alan ekmeğin,
zenginleştirilerek besin değerinin arttırılmasına yönelik çalışmalar gün
geçtikçe önem kazanmaktadır. Bu çalışmada, geleneksel ekmeğe, tıbbi ve aromatik
bitki ya da bitki tohumları eklenerek, ekmeğin fenolik madde içeriğinin
zenginleştirilmesi ve antioksidan bakımından işlevselliğinin arttırılması
amaçlanmıştır. Farklı formülasyonlarla yapılan ekmek numunelerinin toplam
fenolik madde içerikleri Folin-Ciocalteu yöntemine göre bulunmuştur. Sonuçlar
kontrol beyaz ekmekle karşılaştırıldığında, ekmek yapımında özellikle tarçının
toplam fenolik madde içeriğine katkısı oldukça fazla bulunmuş olup, fonksiyonel
ekmek üretiminde kullanılması önerilebilir.
The United States and Asia in 2017
Authors: Sutter Robert
Published: February 2018

Early Trump administration initiatives upset regional stability, complicating the foreign policies of Asian partners and opponents alike. Subsequent pragmatic summitry eased regional anxiety and clarified the new government’s security and political objectives. The administration’s national security strategy, released in December, provided a well-integrated security, economic, and diplomatic strategy for Asia and the rest of the world.
Singapore in 2017
Authors: Ganesan Narayanan
Published: February 2018

Singapore introduced structural changes to its elected presidency that reserve an election for minority candidates. Halimah Yaacob then became the country’s first female Malay president, after running unopposed. Prime Minister Lee Hsien Loong’s siblings were involved in a protracted quarrel over allegations of abuse of power by the prime minister.
Fonološka i morfološka raščlamba jezika Kavanjinova spjeva
Authors: Tomelić Ćurlin Marijana
Published: February 2018

Jezik Kavanjinova djela izaziva zanimanje jezikoslovaca od 19. stoljeća pa sve do danas. Literature naizgled ima, no malo je bibliografskih jedinica posvećeno jezičnoj strani epa. U pojedinim se radovima mogu naći samo neke informacije o jeziku njegova djela. Radu se pristupa s obzirom na nedovoljnu istraženost jezika Kavanjinova spjeva Bogatstvo i uboštvo, na nedostatak opisa na svim jezičnim razinama: fonološkoj, morfološkoj, sintaktičkoj, leksičkoj... Analiza je provedena na drugom, cjelovitom izdanju epa što ga je objavio Josip Aranza pod nazivom Poviest vanđelska bogatoga a nesrećna Epuluna i ubogoga a čestita Lazara. (Bogatstvo i uboštvo.) ‘Velopiesna’ Jerolima Kavań ina (Cavagnini) vlastelina splitskoga i trogirskoga u ediciji Stari pisci hrvatski u Zagrebu 1913. godine. "Jezik u Kavan ́ ina zaslužuje osobitu pažn ́ u i proučavan ́ e (...)", navodi Josip Aranza, priređivač izdanja Kavanjinova spjeva iz 1913. godine te dalje ističe da se upravo u tom spjevu može osjetiti "čudnovato miješanje dijalekata". Kao polazište za istraživanje ovoga rada poslužila je Kravarova (1975: 38) teza da se u djelu ovoga autora osjeća tendencija da se čakavština jednoga Splićanina supstituira dubrovačkim književnim izrazom, odnosno da je zasigurno i ovaj čakavski pisac, kao i njegovi suvremenici pisao dubrovačkom književnom štokavštinom. U radu se donosi fonološka i morfološka raščlamba jezika Kavanjinova spjeva Bogatstvo i uboštvo. Analiza tih jezičnih elemenata trebala bi pokazati koliko je Kavanjinov spjev dio čakavskoga hrvatskoga književnoga izraza, a koliko se u njemu očituje štokavskoga.
Relacija subjekt – svijet u pjesničkoj knjizi Nestvarne djevojčice Marije Čudine
Authors: Lemac Tin
Published: February 2018

Prva pjesnička knjiga Marije Čudine Nestvarne djevojčice (1959) prepoznata je kao zavidan početak i jedno od najsnažnijih ostvarenja u njezinu pjesništvu. Njezine su glavne karakteristike besjedovni stih, intimna drama lirskoga subjekta, tema tijela i užas svijeta. U ovome se radu obrađuje relacija subjekt – svijet koju smatramo paradigmatičnom za ovu zbirku. Intimna drama lirskoga subjekta polarizirana je kategorijama djetinjstva i rata s jedne i egzistencijalističkih toposa s druge strane. Slutnja smrti kao intimistička kategorija usredišćuje subjekt u njegov solipsizam i nemogućnost iskoraka prema svijetu. Na prostorno-vremenskome odnosu prije – sada – poslije smještaju se subjektove diskurzivne strategije i analizira njegov poetski govor. Poetski govor dijelimo na govor o svijetu, govor o smrti i transgresivni govor koji uprisutnjuje nagnuće k smrti. S obzirom na personalnost i impersonalnost kao iskazne moduse, u svakome tipu govora analiziramo opisni, doživljajni i refleksivni diskurz koji se definiraju svojstvenim stilističkim značajkama. Time se proširuje razumijevanje entiteta subjekta i svijeta koji su bitna obilježja cijele Čudinine poetike i usmjerava interpretativna putanja prema pjesničkome opusu.
Učenička percepcija primjene skupinskoga rada u nastavi gramatike
Authors: Bjedov Vesna , Sigurnjak Marija
Published: February 2018

U ovome se radu govori o učeničkoj percepciji primjene skupinskoga rada u nastavi gramatike. Ponajprije se na teorijskoj razini razlažu obilježja skupinskoga rada: kriteriji podjele učenika u skupine, podjela uloga u skupinama, broj učenika u skupini, vrste zadataka, trajanje skupinskoga rada. S obzirom na primjenu skupinskoga rada u nastavi gramatike ističu se Težakovi stavovi i gledišta. U istraživačkome dijelu rada prikazuju se rezultati provedenoga anketiranja na uzorku od 302 učenika petih, šestih, sedmih i osmih razreda dviju osnovnih škola te učenika prvih, drugih i trećih razreda dviju gimnazija. Cilj je bio ispitati učenike o zainteresiranosti za skupinski rad, zatim o čestoti rada u skupinama u nastavi gramatike, ostvarivanju skupinskoga rada u jednome satu i dvosatu, o podjeli uloga u skupinskome radu, zastupljenosti istovrsnih i raznovrsnih zadataka, o broju učenika u skupini, kvaliteti odnosa učenika u skupinskome radu te o procjeni učinkovitosti skupinskoga rada u nastavi gramatike. Rezultati su provedene ankete pokazali da postoji zainteresiranost ispitanih učenika za ovaj oblik rada, ali je organizaciju i provedbu skupinskoga rada u nastavi gramatike moguće poboljšati, poglavito kada je riječ o podjeli uloga u skupinama te oblikovanju kataloga pravila.
Kolumbovo povrće u hrvatskome i ruskome jeziku
Authors: Čelić Željka
Published: February 2018

Zemljopisno porijeklo najrasprostranjenijega povrća koje je Kristofor Kolumbo prenio na europsko tlo 1 jest sjevernoameričko, centralnoameričko i južnoameričko. Kontaktološka teorija potvrđuje jezično posuđivanje riječi (naziva botaničkih vrsta) uz preuzeti objekt. Tako su i nazivi Kolumbova povrća posuđenice u hrvatskome i ruskome jeziku. Usporedit ćemo u radu njihove nazive u dvama slavenskim jezicima, odrediti jesu li posuđenice kalkirane, utvrditi jezik koji je utjecao na kalkiranje, kao i to jesu li kalkirane sa slavenskim korijenom ili su adaptirane (i kako se to adaptiranje očituje na fonološkoj i morfološkoj razini).
Luminal A Breast Cancer and Molecular Assays: A Review
Authors: Gao Jennifer J. , Swain Sandra M.
Published: February 2018

Purpose

Chemotherapy has been the historical mainstay of treatment for patients with breast cancer, with immunohistochemical markers and tumor characteristics driving treatment decisions. The discovery of different intrinsic subtypes of breast cancer has advanced the understanding of breast cancer, with gene-based assays shedding further light on tumor behavior and response to treatment.

Design

This review focuses on the landscape of the luminal A subtype, its definition based on immunohistochemistry (IHC) and gene assays, the prognostic and predictive value of these assays, guideline recommendations, and treatment implications.

Results

Clinical studies of the prognostic value of gene-based and IHC-based assays in patients with luminal A-subtype breast cancers suggest a better prognosis for these patients compared with those with breast cancers of other subtypes.

Conclusion

In today's era of precision medicine, the best treatment regimen for patients with luminal A-subtype tumors is still undetermined, but available data raise the question whether chemotherapy can be omitted and endocrine therapy alone is sufficient for this patient population.

Implications for Practice

Immunohistochemical markers have traditionally guided treatment decisions in breast cancer. However, advances in gene-expression profiling and availability of gene-based assays have launched these newer tests into everyday clinical practice. Luminal A-subtype tumors are a unique subset that may have favorable tumor biology. Properly defining this tumor subtype is important and may identify a subset of patients for whom endocrine therapy alone is sufficient.
Deterioration of concrete structures along with case studies in India
Authors: Bhattacharjee Jogatjyoti
Published: February 2018

Concrete is used extensively in various types of construction works. However, the deterioration of reinforced-concrete structures is recognised as a major problem worldwide. Apart from requiring regular maintenance, many structures require extensive repair, rehabilitation and retrofitting. Over a period of time, as these structures become older, certain degradation or deterioration with resultant distress manifested in the form of cracking, splitting, delaminating and corrosion is found in them. Such deteriorated structures can be rehabilitated and retrofitted by using various types of admixtures and modern repair materials. This paper discusses the present state of concrete structures and the major areas where improvement is needed during the service life stage for sustainable development. It also discusses the method of carrying out repair, rehabilitation and retrofitting. This is detailed in the paper along with various case studies compiled by the author based on his field experience of direct involvement in the planning and execution of repair and rehabilitation jobs, which were successfully completed by using the latest repair materials and techniques.
Characteristics of the flow field downstream of free and submerged hydraulic jumps
Authors: Habibzadeh Alireza , Rajaratnam Nallamuthu , Loewen Mark
Published: February 2018

Flow characteristics downstream of free and submerged hydraulic jumps with and without blocks were experimentally studied for Froude numbers ranging from 3·48 to 6·85. The streamwise variation of the mean longitudinal velocity, turbulence intensity and turbulent kinetic energy as well as bed shear stress and water surface fluctuations were studied and compared for different flow regimes. Empirical equations are presented for longitudinal variations of the bed shear stress and water surface fluctuation for free and submerged jumps with and without blocks. The length required for the bed shear stress and water surface fluctuation to attain asymptotic magnitudes was used to define new characteristic lengths for hydraulic jumps. The results of this study show the effects of blocks in determining the longitudinal extension of hydraulic jumps. It was found that the presence of the blocks damped the streamwise variation of the studied flow parameters in a significantly shorter distance. It was also found that the deflected surface jet regime that occurred in submerged jumps with blocks had streamwise characteristics similar to those of free jumps with blocks. The results of this study confirm that this flow regime of submerged jumps can effectively be used as an energy dissipator within a stilling basin with a length approximately equal to that required for free jumps.
HDL in CKD—The Devil Is in the Detail
Authors: Kronenberg Florian
Published: February 2018

The picture of HDL cholesterol (HDL-C) as the “good” cholesterol has eroded. This is even more surprising because there exists strong evidence that HDL-C is associated with cardiovascular disease (CVD) in the general population as well as in patients with impairment of kidney function and/or progression of CKD. However, drugs that dramatically increase HDL-C have mostly failed to decrease CVD events. Furthermore, genetic studies took the same line, as genetic variants that have a pronounced influence on HDL-C concentrations did not show an association with cardiovascular risk. For many, this was not surprising, given that an HDL particle is highly complex and carries >80 proteins and several hundred lipid species. Simply measuring cholesterol might not reflect the variety of biologic effects of heterogeneous HDL particles. Therefore, functional studies and the involvement of HDL components in the reverse cholesterol transport, including the cholesterol efflux capacity, have become a further focus of study during recent years. As also observed for other aspects, CKD populations behave differently compared with non-CKD populations. Although clear disturbances have been observed for the “functionality” of HDL particles in patients with CKD, this did not necessarily translate into clear-cut associations with outcomes.
Socio-environmental factors and diarrheal diseases in children aged zero to four years in the state of Tocantins, Brazil v1
Authors: Morais Fontoura Volmar , Graepp Fontoura Iolanda , Stabnow Santos Floriacy , Santos Neto Marcelino , Santos de Almeida Tavares Hanari , Onice Lopes Bezerra Maria , de Oliveira Feitosa Marcela , Figuerêdo Neves Adriano , Cavalcante Melo de Morais Jesuane , Fernando Costa Nascimento Luiz
Published: February 2018

Antecedentes : A diarréia é uma doença transmitida pela água que afeta as crianças, especialmente as menores de quatro anos de idade. O objetivo deste estudo foi identificar os padrões espaciais de distribuição de doenças diarréicas em menores de 4 anos no Estado do Tocantins, Brasil, de 2008 a 2013. Métodos : ferramentas de geoprocessamento foram utilizadas para realizar um estudo epidemiológico, para preparar mapas temáticos no software TerraView 4.2.2, com dados secundários. Foram descritos indicadores gerais da doença, presença de dependência espacial através do Índice Global Moran (I) e do Índice de Associação Espacial (LISA). Resultados : houve 3.015 casos de crianças com menos de 4 anos internadas por diarréia, com uma taxa anual média (AAR) de 4.10 / 1.000 habitantes (hab.). Entre as principais características foram: aumento das taxas em menores de 1 ano (6,16 a 9,66 / 1.000 habitantes); 1 a 4 anos de idade (63%); machos (55%); 8 mortes, com menos de um ano de idade (75%); município de Araguaína (67%); incidente no município de Nazaré (63,97 / 1.000 hab.); prevalência e incidência na microrregião Araguaína (45%, AAR 9,38 / 1.000 habitantes). A presença de um cluster com autocorrelação espacial foi encontrada na micro região de Araguaína, que foi estatisticamente significante (I = 0,11, p- valor <0,03), com prioridade de intervenção (Moran Map). Conclusões : houve um aumento no número de internações por diarréia em crianças com menos de 4 anos de idade no estado de Tocantins. A análise espacial identificou grupos de áreas prioritárias para medidas de manutenção e controle de doenças diarréicas.
Kromozomal bozuklukların referans test ile doğrulanamadığı durumda iki aşamalı Bayes yöntemiyle performans ölçülerinin değerlendirilmesi
Authors: DERİCİ YILDIRIM Didem , TAŞDELEN Bahar , ÇAYAN Filiz , İZCİ AY Özlem , AY Mustafa Ertan
Published: February 2018

Amaç: Kromozomal anormallik prevalansını ve diagnostik testlerin doğruluğunu tahmin etmek kromozomal bozukluklar altın Standard test ile doğrulanamadığı durumda ciddi bir problemdir. Bu çalışmanın amacı tanı testlerinin performasını ve kromozomal anomali prevalansını bayes analizi ile tahmin etmektir. Gereç ve Yöntem: Ağustos 2014 ve Ağustos 2015 tarihleri arasında Mersin Üniversitesi Hastanesi Kadın Hastalıkları ve Doğum polikliniğine başvurmuş gebeler çalışmaya dahil edilmiştir. Başvuran gebeler içerisinden, birinci trimester dönemde ultrasonografi ve ikili tarama test sonucu olan 1759 gebeye ait kayıtlardan yararlanılmıştır. İki Aşamalı Bayes yöntemi kullanılmıştır. İlk aşamada, bireyler hasta ve sağlıklı olarak sınıflandırılmaktadır. İkinci aşamada ise ilk aşamada hasta ya da sağlıklı olduğuna karar verilen bireylere altın standart test uygulanarak durumları doğrulanmaktadır. Bulgular: Önsel dağılım bilgisi olduğu durumda, birlikte duyarlılık ve seçicilik değerleri %77 ve %99 olarak tahmin edilmiştir. Önsel dağılım bilgisi olmadığı durumda ise, birlikte duyarlılık ve seçicilik değerleri %50 ve %97 olarak tahmin edilmiştir. Sapma Bilgi Ölçütü (DIC) ve Monte Carlo Hata (MC) değerleri birlikte incelendiğinde, önsel bilgi olduğu durumda modele uyum daha iyidir. Sonuç: Doğrulanamama problemi ile gebelikte uygulanan rutin tarama testleri için sıklıkla karşılaşılmaktadır. Tarama testlerinin doğruluğu bu yöntemden yararlanılarak daha doğru şekilde tahmin edilmektedir.
Investigation of the effects of nicotine and resveratrol on expression levels of Sox2 and Sox4 genes in human amniotic cell culture by real time PCR
Authors: CÖMERTPAY Gamze , LÜLEYAP Ümit , YILMAZ Mehmet Bertan , TUFAN Turan , PAZARCI Perçin
Published: February 2018

Purpose: The aim of this study was to show the effects of nicotine on expression levels of SOX2 and SOX4 genes, which are known for their master gene features, in human amniotic cell cultures. The study also aimed to show the effects of resveratrol, an antioxidant, on expression levels of these genes in human amniotic cell cultures, which are treated by nicotine.Material and Methods: Twenty patients were included in this study and for each patient; control, nicotine treated and nicotine + resveratrol treated cell culture groups are formed. The expression levels of SOX2 and SOX4 genes are examined in each group by using real time RT-PCR.Results: Change in expression levels of SOX2 and SOX4 genes in nicotine treated group were found to be statistically significant. Also, when groups treated with nicotine and nicotine + resveratrol were compared the difference was found to be statistically significant.Conclusions: Nicotine increased the expression levels of SOX2 and SOX4 genes by 60% in human amniotic cell cultures and resveratrol was found to be an important antioxidant that reduces the increased expression levels of SOX2 and SOX4 genes caused by nicotine treatment.
Üniversitede okuyan kız öğrencilerde depresyon prevalansı ve ilişkili faktörler
Authors: AÇIKGÖZ Ayla , DAYI Ayfer , BİNBAY Tolga
Published: February 2018

maç: Bu çalışma, üniversitede okuyan kız öğrencilerde depresyon prevalansını belirlemek; bireysel, sosyodemografik ve sağlıkla ilişkili faktörlerin depresyonla ilişkisini araştırmak amacıyla yapılmıştır. Gereç ve Yöntem: Bu kesitsel araştırma 618 üniversite öğrencisi üzerinde yapılmıştır. Dokuz Eylül Üniversitesi’nin sağlık kampüsündeki Tıp Fakültesi, Hemşirelik Fakültesi, Fizik Tedavi ve Rehabilitasyon Yüksekokulu, Sağlık Hizmetleri Meslek Yüksekokulu’nun birinci sınıfında okuyan kız öğrenciler araştırma kapsamına alınmıştır. Öğrencilere öğrenci tanıtım formu ve Beck Depresyon Ölçeği (BDÖ) uygulanmıştır. Verilerin istatistiksel analizinde ki-kare testi, bağımsız gruplarda t testi, Mann-Whitney U testi, tek yönlü ANOVA testi ve lojistik regresyon analizi uygulanmıştır. Bulgular: Araştırma grubunun BDÖ skoru ortalaması 11.5±9.6 ve depresyon prevalansı (Beck Depresyon Ölçeği puanı ≥17) %25.6 olarak bulunmuştur. Anne babası ayrı olan, yurtta kalan, ekonomik algısı çok kötü ve kötü olan, kronik hastalığı olan, anemisi olan, sigara ve alkol kullanan, ruhsal/psikolojik sorun öyküsü olan öğrencilerde BDÖ puanı ortalaması ve depresyon prevalansı daha yüksek bulunmuştur. Sonuç: Öğrencilerin yaklaşık dörtte birinde depresyon vardır. Ekonomik düzey düşüklüğü, sağlıksız yaşam biçimi davranışları, kronik hastalık ve ruhsal sorun öyküsü, öğrencilerde depresyon prevalansını etkileyen en önemli faktörlerdir. Öğrencilere sigara, alkol, yanlış beslenme gibi sağlıksız yaşam biçimi davranışlarının azaltılmasına yönelik girişim çalışmaları yapılabilir. Üniversite öğrencilerine yönelik koruyucu ruh sağlığı programlarının geliştirilmesi ve uygulanması önerilir.
Üç yaş altı anaplastik ependimom olgularının tedavisi
Authors: YAĞCI-KÜPELİ Begül , KÜPELİ Serhan Küpeli
Published: February 2018

Çocukluk çağı ependimomlarının yaklaşık üçte ikisi posterior fossa yerleşimli olup daha az bir kısmı supratentorial veya spinal intramedüller yerleşimlidir. Düşük yaş grubu, tam olmayan rezeksiyon ve anaplastik ependimom kötü prognostik kriterlerdendir. İntrakranial anaplastik ependimom hastalarının çoğunda radyoterapi endikasyonu mevcuttur. Kemoterapinin sağkalım üzerine etkisi tartışmalıdır. Bu çalışmada anaplastik ependimom tanısını 3 yaş altında alan iki hasta sunulmuştur. Her iki olguda da tedaviye kemoterapi ile başlanmış ve 36 ayı doldurduklarında radyoterapi verilmiştir. Daha etkili tedavi yöntemleri geliştirilinceye kadar 3 yaş altındaki anaplastik ependimom olgularına adjuvan kemoterapi ve sonrasında radyoterapi uygulanması etkili gözükmektedir.
Chylous ascites: an unusual complication of peritoneal dialysis in an infant with congenital nephrotic syndrome
Authors: EKİNCİ Faruk , YILDIZDAŞ Rıza Dinçer , HOROZ Özden Özgür , MELEK Engin , PETMEZCİ Ercüment , TOLUNAY İlknur
Published: February 2018

Chylous ascites is a rare but important non-infectious complication in patients undergoing peritoneal dialysis. A male infant of 1.5-month-old with congenital nephrotic syndrome admitted to our pediatric intensive care unit becasue of deterioration in general appearence, diffuse edematous appearance and respiratory distress. Peritoneal catheter insertion and peritoneal dialysis was performed in the 3rd day of hospitalization. Five days after peritoneal dialysis catheter insertion (on the 8th day of hospitalization) the peritoneal dialysis effluent had a milky appearance. The chemical analysis of the milky effluent showed characteristics of chylous ascites: triglycerides 468 mg/dl. The chylous ascites resolved at the 5th day of our treatment with a low fat diet with medium chain triglycerides and intravenous infusion of somatostatin analogue (octreotide) and the patient was transferred to the pediatric service for maintenance of the treatment.
A misleading cutaneous lesion for the surgeon: pyoderma gangrenosum
Authors: KORKMAZ SOLMAZ Güllü , ÇÖLOĞLU Harun , DURDU Murat , ERTAŞ Nilgün
Published: February 2018

Pyoderma gangrenosum is a rare inflammatory skin disorder characterized by cutaneous papulo-pustules that evolve rapidly into large, painful, necrotic ulcers.  These lesions are often initially diagnosed as wound infection and necrotizing fasciitis. Debridement, although the standard of care for wound infections, is paradoxically detrimental in pyoderma gangrenosum because of pathergy. Early diagnosis and treatment of pyoderma gangrenosum is very important because unnecessary debridement and associated morbidity can be prevented. Herein, we report a case with pyoderma gangrenosum mimicking necrotizing fasciitis.
An unusual complication of percutaneous tracheostomy: tracheoesophageal defect
Authors: TAŞ Adnan , TAŞ Hacer
Published: February 2018

An unusual complication of percutaneous tracheostomy: Tracheoesophageal defect
Cystic lymphangioma of parotid gland in a 51 year old male
Authors: Bajpai Manas , Pardhe Nilesh , Vijay Pradkshana
Published: February 2018

-
Lista Kontrolna Zaburzenia Osobowości z Pogranicza (BPD): ocena psychometryczna i struktura czynnikowa w próbie klinicznej i nieklinicznej
Authors: Bloo Joos , Arntz Arnoud , Schouten Erik
Published: February 2018

The present study examined the assessment and conceptualization of borderline personality disorder with the Borderline Personality Disorder Checklist (BPD Checklist). The BPD Checklist is a DSM-IV based self-report questionnaire, designed to assess the experienced burden of specific BPD symptoms during the previous month. The participants in the study were 140 BPD patients, 55 Cluster C personality disorder patients, 57 patients with only Axis I psychopathology, and 87 nonclinical controls. The psychometric properties of the BPD Checklist and changes during treatment were assessed. First-order confirmatory factor analyses using the BPD Checklist items on seven dimensional BPD models supported both a one-dimensional BPD model and a nine-dimensional one, the latter based on the DSM-IV criteria. Internal consistency as well as construct, concurrent, and discriminant validity proved to be very good. Clinical norms and cutoff scores with high sensitivity and specificity were derived. The questionnaire is suitable as a scre-ening instrument and treatment outcome measure since it proved to be sensitive to change.