bluuebunny/crossref_metadata_2025 huggingface dataset:
Precision Medicine in Improving Treatment Outcomes in Hepatocellular Carcinoma: Clinical Outcomes and Advancements
Authors: Singh Deepti , Khan Mohammad Afsar , Siddique Hifzur R.
Published: June 2024

Liver cancer ranks sixth among the most commonly diagnosed malignancies
and 90% of liver cancer cases are of Hepatocellular carcinoma (HCC). Treatment
options for HCC include resection, radiotherapy, and systemic therapies with
chemotherapeutic drugs. The late diagnosis of HCC prevents successful treatment by
surgical resection. Further, conventional treatment modalities such as chemotherapy
and radiotherapy are ineffective in all patients as tumors are heterogeneous. The
heterogeneous nature of tumors enables them to have genetic variations and express
specific proteins in different patients. This inherent variability of cancer creates the
need to move to a growing field of medicine, i.e., precision/personalized medicine.
Precision medicine is based on complementing the molecular profile of a patient to a
targeted therapy. In clinical practice, the transition from a stage-based approach to a
targeted therapy-based approach is necessary for determining the most appropriate
treatment plan for a patient. The clinical outcomes for patients could be improved on a
large scale if the discoveries in tumour biology are applied efficiently in clinics. This
chapter discusses the research on precision medicine for improving treatment outcomes
in HCC patients, especially advanced cancers. It also includes the clinical studies of
novel therapeutics used for the targeted therapy of advanced liver cancer patients.
Concisely, we summarize the recent studies on the applications of precision and
personalized medicine.
Protein Structures, Aggregation, Misfolding, Induction Factors and Precision Medicine
Authors: Malik Sadia , Yasmeen Sumbul , Khan Rizwan Hasan
Published: June 2024

The aggregation of protein is a complex process influenced by various
factors resulting in a wide range of debilitating disorders. These are characterized by
the deposition of insoluble plaques consisting of amyloid fibrils rich in β-sheet
structures. Many natural proteins form amyloid fibrils and build-up misfolded or
aggregated disease-specific proteins in the tissues causing human diseases. The present
chapter deals with protein structures, aggregation, misfolding, induction factors, and
their involvement in human disease and implications in precision medicine. We have
discussed the role of functional amyloids in portraying the mechanism of its formation,
highlighting the method of detection of diverse types of aggregates. Moreover, we also
contextualized therapeutic strategies to combat the process of aggregation keeping in
view that this is a broad field of research that ranges from biophysics to clinical trials.
Despite visible progress in the field of biochemistry, we still have questions regarding
the aggregation and co-aggregation of protein molecules. However, with the present
level of knowledge, it is envisaged that accurate treatments against diseases related to
aggregation would be feasible in near future.
Resiliency of Protein Dictates Human Health
Authors: Chandel Tajalli Ilm , Fareed Ifrah , Khan Rizwan Hasan
Published: June 2024

Proteins are functional in their three-dimensional form; any type of
modification in the conformation of the protein affects its functions. Thus, the role of
the proteins in the body depicts the functional ability and ensures health of an
organism. Besides its presence in the body, proteins are consumed by the body in the
form of dietary uptake. The free amino group of the protein in the body when
interacting with the carbonyl group of the reducing sugar follows the Maillard reaction
to produce hazardous by-products which is an advanced glycation end products
(AGEs). The process of AGEs formation routes towards the aggregation process.
Different studies have shown different aggregation pathways, some restricting the
partial unfolding of the protein and the other oligomerization leading to fibril formation
depending upon the conditions of the study. It is noteworthy that in in-vivo cases,
glycation and aggregation are the two sides of the same coin because it is obvious that
we have seen the diseased condition due to AGEs formation that also shows
aggregation or vice versa. Hence, the two causative agents depend upon each other.
Molecular Mechanisms Implicated with Depression and Therapeutic Intervention
Authors: Anand Loveleena Kour , Maqbool Mir Shahid , Malik Fayaz
Published: June 2024

Depression is a pervasive, arduous psychological condition with profound
neurological ramifications. The parameters for leveraging depression involve the
diagnosis and evaluation of depression, the endorsement to implement substantiated
therapies and rigorous follow-up of the patients. Many individuals suffering from
depression undertake a recurring or persistent therapy that correlates to a decline in
cognitive processing. The underpinnings of exact aetiology and pathogenesis of
melancholy are probably the outcome of a variety of mechanisms. These include
physiological, behavioural, and socio-economic variables, all playing their roles.
Multiple refinements to the treatments encompassing therapies, medications and
medical interventions are employed, in relation to effective approaches reassuring the
brighter side. In this chapter, we discuss more integrative and multifaceted aspects of
psychological health, minimizing the segmented understanding to achieve a consensus
on multiple possibilities for effective interventions.
High Altitude Hypoxia Stressor Associated Diseases and Precision Medicine
Authors: Paul Subhojit , Gangwar Anamika , Mohanthy Swaraj , Ahmad Yasmin
Published: June 2024

Hypoxia is a condition wherein an organism, a cell or a region of an organ
does not receive adequate levels of oxygen to carry out normal life processes. The
ability to sense oxygen levels and respond appropriately is termed “oxygen sensing”
which might be used in certain cases to describe the biological effects of hypoxia.
Hypoxia is an important facet involved in multiple diseases. Ranging from highaltitude pulmonary edema to cancer, oxygen-sensing molecular networks are crucial for
survival and have a notable impact on human health systems. The type, duration, and
intensity of hypoxic episodes have been found to have a multitude of effects ranging
from beneficial to harmful in diverse conditions like obesity, type 2 diabetes and
obstructive sleep apnea. A very important niche of hypoxia is the study of
environmental stressors also called high-altitude hypoxia. High-altitude hypoxia holds
multiple molecular similarities with diabetes, cancer, obesity, and other diseases like
COPD. In addition, unregulated exposure to hypobaric hypoxia is known to directly
cause high-altitude illnesses like HAPE/HACE. An interesting facet of high-altitude
hypoxia is the ability of the molecular and physiological systems to acclimatize to the
high altitude. This acclimatization is known to prevent the occurrence of high-altitude
illnesses. This review highlights the previous studies to build a framework that
elucidates the occurrence of hypobaric hypoxia, its socio-economic impact, molecular
underpinnings, and correlation with inflammation, cancer, diabetes, obesity and
possible therapeutic approaches to these diseases.
Resiliensi Masyarakat Penghuni Sempadan Sungai Madiun Dalam Menghadapi Banjir
Authors: Wahyudi Adip , Ritohardoyo Su , Pitoyo Agus Joko
Published: June 2024

Masyarakat penghuni sempadan Sungai Madiun memiliki tingkat risiko yang tinggi terhadap bencana banjir, hal ini disebabkan mereka tinggal di sempadan sungai. Metode yang digunakan adalah analisis kuantitatif dan kualitatif terhadap data hasil wawancara dan observasi. Variabel untuk menilai resiliensi meliputi modal alam, modal fisik, modal sumberdaya manusia, modal sosial dan modal finansial. Hasil penelitian menunjukkan bahwa masyarakat mempunyai resiliensi yang tinggi dalam menghadapi bencana banjir. Dari lima variabel yang dilakukan pengujian, modal sosial dan modal sumber daya manusia mempunyai nilai yang tinggi dengan persentase 86% dan 84,8% dalam membentuk resiliensi masyarakat penghuni sempadan Sungai Madiun dalam menghadapi bencana banjir. tingginya nilai tersebut dipengaruhi oleh budaya gotong royong dalam membantu korban bencana bajir. Selain itu, pengetahuan dan persepsi masyarakat tentang banjir membentuk suatu karakter masyarakat yang tangguh menghadapi bencana. Dengan demikian, dalam penanggulangan bencana banjir di Sungai Madiun maka perlu upaya untuk peningkatan modal fisik, dan finansial masyarakat.
Problematika Pembelajaran di Era Pandemi COVID-19 Stud Kasus: Indonesia, Filipina, Nigeria, Ethiopia, Finlandia, dan Jerman
Authors: Putro Sutanto Trijuni , Widyastuti Mawanti , Hastuti Hastuti
Published: June 2024

The Covid-19 pandemic has brought significant changes in the world of learning. Many countries are closing schools and universities to prevent the spread and break the chain of the covid-19 virus. As a result of the closure, distance learning was implemented through various existing media. Each country has different conditions, so learning during this pandemic experiences different challenges and problems. These differences are interesting to study to provide an overview of what is happening in the country and can be used as an evaluation in the future. This study was conducted through literature studies with various sources, both journals and selected online news. The selected countries are Indonesia, Philippines, Ethiopia, Nigeria, Finland and Germany. The selection is done randomly without any particular background, but representing the existing continents. Based on the results of the study, the responses, strategies and obstacles that occurred in the education sector during the pandemic was listed. The strategies, successes, and obstacles that occurred in each country were influenced by the readiness of infrastructure up to human resources, as well as the initial conditions of the country before the pandemic.
Kajian Struktur Ruang Kecamatan Serengan Kota Surakarta
Authors: Ma'sum Moh. Ali
Published: June 2024

Kecamatan Serengan sebagai salah satu kecamatan dengan penerapan sistem perkotaan di Kota Surakarta yang sudah terus mengalami perkembangan. Struktur ruang merupakan tatanan dari pusat pemukiman serta sistem sarana prasarana yang berguna dalam mendukung kegiatan ekonomi dan sosial masyarakat dimana secara hierarki mempunyai hubungan fungsional. Karena hal tersebut maka penulis mengkaji penelitian ini dengan tujuan untuk mengetahui struktur ruang Kecamatan Serengan Kota Surakarta. Penulis menggunakan jenis penelitian deskriptif dengan menerapkan pendekatan kuantitatif serta variabel penelitian ini berupa sarana prasarana yaitu fasilitas pelayanan masyarakat dan jaringan jalan. Hasil penelitian menunjukankan bentuk struktur kecamatan Serengan mendekati konsep pola konsentris, dimana pusat perkembangan dan pertumbuhan berada di tengah-tengah kecamatan Serengan selain itu model struktur ruangnya yaitu multi nodal karena terdiri dari pusat, sub pusat serta pusat lainya.
Analisis neraca airtanah Kota Dobo, Kepulauan Aru, Maluku
Authors: Febriarta Erik
Published: June 2024

Neraca airtanah merupakan kondisi pemanfaatan dengan ketersediaan airtanah. Tujuan dari penelitian ini adalah menghitung neraca sumber daya airtanah Kota Dobo yang berada di Pulau Wamar. Pendekatan kuantitatif digunakan untuk mengetahui ketersediaan air tanah dari sifat batuan dalam menyimpan dan meloloskan air tanah. Data yang digunakan antara lain curah hujan dari data sekunder, luas wilayah dari pehitungan keruangan dan faktor geologi daridata litologi. Analisis imbuhan (RC) air tanah dengan menggunakan data dari sifat kemampuan menyimpan air tanah terhadap luas wilayah dari imbuhan air hujan. Diketahui ketersediaan sumber daya air di Kota Dobo sebesar 30.849.053.309,7 m3/tahun. Perbandingan perhitungan pemanafaatan air yang dihitung antara lain rumah tangga (domestik), sekolah, kantor, tempat ibadah, industri, pertanian, peternakan, dan pemanfaatan air pariwisata dari data sekunder. Nilai total kebutuhan atau pemanfaatan di Kota Dobo sebesar 29.886.312,4 m3/tahun (0,1 % ketersediaan air), sehingga masih tersedia cadangan sebesar 30.819.166.997,3 m3/tahun (99,9%) yaitu bernilai surplus atau masih dapat mencukupi kebutuhan air bersih.
Analisis Evapotranspirasi Pada Waduk Bening di SubDAS Brantas
Authors: Azizah Vischawafiq , Cholidah Nina Nila Ziyana , Sari Risky Rena Anggia , Religi Muhammad Denzel , Masitoh Ferryati
Published: June 2024

Evapotranspirasi merupakan serangkaian proses bagaimana suatu lahan tanaman mengalami kehilangan kadar air melalui proses evaporasi dan transpirasi. Besaran nilai evapotrasnpirasi sendiri dipengaruhi oleh beberapa faktor, seperti suhu, ketinggian, jenis tanaman, letak lintang, lama penyinaran matahari, curah hujan dan faktor cuaca yang lain (faktor yang berada dalam parameter yang ada). Tujuan dari penelitian ini adalah mengetahui nilai evapotranspirasi di Waduk Bening di kawasan DAS Widas dengan menggunakan ketujuh metode berdasarkan data pada acara sebelumnya dan membuat matrik hasil nilai evapotranspirasi setiap metode yang digunakan. Persamaan metode yang digunakan dalam perhitungan evapotranspirasi estimasi evaporasi yaitu Metode Thornwaite, Metode Blaney Criddle, Metode Blaney Criddle Modifikasi, Metode Turc Lungbein, Metode Penman-FAO, Metode Hargreaves, dan Metode Cristainsen. Hasil nilai dalam perhitungan evapotranspirasi pada semua persamaan metode perhitungan mengalami kenaikan dan distribusi nilainya berbeda-beda serta cenderung meningkat menjelang akhir tahun. Hal ini disebabkan pemanasan global yang terjadi dan kecenderungan rata-rata suhu tahunan yang mengalami kenaikan.
Model Regresi Spasial untuk Pendugaan Intrusi Air Laut Berdasarkan Relasi Pengukuran Salinitas terhadap Vegetation Soil Salinity Index
Authors: Dermawan Ananda , Ghazali Mochamad Firman , Salsabila Choirunnisa , Zahra Lauditta , Aulia Mila , Suastini Ni Made Mega Melliana
Published: June 2024

Intrusi air laut di wilayah pesisir sering menjadi permasalahan bagi lingkungan sekitarnya sehingga perlu dilakukan upaya untuk mengidentifikasi keberadaan intrusi tersebut. Hal ini dapat dinilai menggunakan teknologi penginderaan jauh. penelitian ini dilakukan dengan menganalisis Citra Satelit Sentinel-2, data salinitas dari pengukuran lapangan, dan perhitungan statistik. Salinitas tanah akan diperkirakan menggunakan vegetation soil salinity index (VSSI). Penelitian ini mengintegrasikan data pengukuran salinitas lapangan dengan VSSI untuk membangun model persamaam regresi linear dan nonlinear. Ada tiga model regresi yang digunakan yaitu regresi linear, regresi eksponensial, dan regesi polynomial. Analisis ketiga model tersebut menunjukkan bahwa regersi polynomial merupakan model yang paling sesuai untuk estimasi salinitas berdasarkan VSSI dengan nilai koefisien determinasi (R2) 11,04%. Hasil estimasi salinitas berdasarkan VSSI menggunakan model polynomial memiliki koreasi yang cukup baik terhadap observasi salinitas dengan nilai koefisien determinasi (R2) 42,49%, sedangkan validasi estimasi tersebut memiliki akurasi cukup tinggi dengan nilai RMSE 0,0013% dan MAE 0,0011%. Kata kunci : Intrusi air laut, Salinitas, Analisis regresi, Sentinel-2, VSSI
Effect of Volcanic Sand-Biocarbon-Zeolith Filtration on pH, EC, and TDS values of karst groundwater
Authors: Budiyanto Eko , Muzayanah Muzayanah , Kurniawati Aida , Purnomo Nugroho Hari
Published: June 2024

Filtration is a very important process because naturally karst landscapes do not provide good protection against groundwater. This study aims to determine the effect of filtration with sand, biocarbon, and zeolite materials on the pH, EC and TDS values. The research was conducted using an experimental method using three filtration tubes filled with these three materials. Samples were taken from ten different water sources. The results of the analysis show that the filtration process of a combination of sand, biocarbon, and zeolite materials has the effect of increasing the pH value, and decreasing the EC and TDS values. The filtration process through a combination of volcanic sand, biocarbon and zeolith materials simultaneously gives a more significant change in pH, EC, and TDS values compared to filtration with these materials separately.
Economic Resilience to Disasters in 1999–2022: A Bibliometric Literature Review with Future Research Direction Amid the Global COVID-19 Pandemic
Authors: SUHERNINGTYAS IKA AFIANITA
Published: June 2024

This literature review examines the current trend of academic papers on economic resilience (ER) as part of disaster risk reduction from 1999 to 2022 using bibliometrics. The purpose is to fill the knowledge gaps and suggest future research direction in this field, especially after the global impact of the COVID-19 pandemic. The Scopus database’s search using pertinent keywords produced 309 documents written by 340 academics from 41 countries and issued in 86 digital documents. Using the inclusion and exclusion criteria, further screening resulted in 128 documents. The bibliometric analyses comprised the identification of three major research streams to understand the research evolution, co-citation analysis and bibliometric coupling (clustering), and identification of the knowledge gaps to discover the future orientation of ER studies. The three main findings of this review are as follows. First, the ER field evolved in three stages: emergence (1999–2006), acknowledgment (gaining scholars’ attention, 2006–2014), and rapid growth (2014–2022). Second, ER theories that influence most of the works are those of Rose (2004), Holling (1973), and Mileti (1999), with Rose as the most cited in Natural Hazards, Advances in Spatial Science, and International Journal of Disaster and Risk Reduction. By country, the United States and China are the largest contributors to scholarly publications on ER. Third, it is likely that future research will be centered around economic resilience to the COVID-19 pandemic. This study is part of the existing and emerging research streams that also provides potential research direction of ER for disaster risk reduction in the future.
Kajian Kawasan Permukiman Pantai Samas, Kabupaten Bantul, Daerah Istimewa Yogyakarta
Authors: Setyaningrum Agustina , Masduqi Edy , Prasetiyowati Sri Haryanti , Widyaputra Primanda Kiky , Setyorini Heny Budi
Published: June 2024

Permukiman Pantai Samas berpotensi dipengaruhi oleh berbagai aktivitas masyarakat antara lain aktivitas pariwisata, pertanian dan perikanan. Kondisi permukiman menjadi sangat dinamis. Tujuan dari penelitian ini adalah 1) untuk melakukan penilaian kondisi kawasan permukiman pesisir di wilayah Pantai Samas dan 2) untuk menyusun rekomendasi penanganan kawasan permukiman Pantai Samas. Data primer dikumpulkan melalui diskusi kelompok terarah, wawancara mendalam dengan informan kunci, dan survey lapangan dengan menggunakan kuesioner. Data sekunder diperoleh dari studi literatur dan kajian serupa sebelumnya yang sudah dilakukan. Data yang telah dikumpulkan selanjutnya dianalisis dengan menggunakan analisis statistik deskriptif. Hasil penelitian menunjukkan bahwa tidak semua wilayah RT masuk kedalam kategori kumuh. Terdapat tiga RT yang masuk dalam kategori kumuh rendah, dengan nilai yang cukup rendah. Permasalahan utama penyebab kekumuhan adalah kondisi jalan lingkungan yang rusak, tidak adanya saluran drainase dan belum adanya sistem hidran umum sebagai mitigasi kebakaran. Rekomendasi penangan rendah untuk melakukan perbaikan jalan lingkungan dan pembangunan saluran drainase dan sistem hidran umum.
Social Media Promotion of Health Tests With Potential for Overdiagnosis or Overuse: Protocol for a Content Analysis
Authors: Nickel Brooke , Heiss Raffael , Shih Patti , Gram Emma Grundtvig , Copp Tessa , Taba Melody , Moynihan Ray , Zadro Joshua
Published: June 2024

Background

In recent years, social media have emerged as important spaces for commercial marketing of health tests, which can be used for the screening and diagnosis of otherwise generally healthy people. However, little is known about how health tests are promoted on social media, whether the information provided is accurate and balanced, and if there is transparency around conflicts of interest.

Objective

This study aims to understand and quantify how social media is being used to discuss or promote health tests with the potential for overdiagnosis or overuse to generally healthy people.

Methods

Content analysis of social media posts on the anti-Mullerian hormone test, whole-body magnetic resonance imaging scan, multicancer early detection, testosterone test, and gut microbe test from influential international social media accounts on Instagram and TikTok. The 5 tests have been identified as having the following criteria: (1) there are evidence-based concerns about overdiagnosis or overuse, (2) there is evidence or concerns that the results of tests do not lead to improved health outcomes for generally healthy people and may cause harm or waste, and (3) the tests are being promoted on social media to generally healthy people. English language text-only posts, images, infographics, articles, recorded videos including reels, and audio-only posts are included. Posts from accounts with <1000 followers as well as stories, live videos, and non-English posts are excluded. Using keywords related to the test, the top posts were searched and screened until there were 100 eligible posts from each platform for each test (total of 1000 posts). Data from the caption, video, and on-screen text are being summarized and extracted into a Microsoft Excel (Microsoft Corporation) spreadsheet and included in the analysis. The analysis will take a combined inductive approach when generating key themes and a deductive approach using a prespecified framework. Quantitative data will be analyzed in Stata SE (version 18.0; Stata Corp).

Results

Data on Instagram and TikTok have been searched and screened. Analysis has now commenced. The findings will be disseminated via publications in peer-reviewed international medical journals and will also be presented at national and international conferences in late 2024 and 2025.

Conclusions

This study will contribute to the limited evidence base on the nature of the relationship between social media and the problems of overdiagnosis and overuse of health care services. This understanding is essential to develop strategies to mitigate potential harm and plan solutions, with the aim of helping to protect members of the public from being marketed low-value tests, becoming patients unnecessarily, and taking resources away from genuine needs within the health system.

International Registered Report Identifier (IRRID)

DERR1-10.2196/56899
Low-Grade Ilmenite Leaching Kinetics Using Hydrochloric Acid: RSM and SCM Approaches
Authors: Supriyatna Yayat Iman , Prasetya Agus , Astuti Widi , Sumardi Slamet , Natalia Priskila , Adythia Dicky Marsa , Petrus Himawan Tri Bayu Murti
Published: June 2024

Minerals containing TiO2 are common in Indonesia, such as ilmenite in iron sand deposits scattered along the country's coasts. Ilmenite is an important source of titanium. One method for making TiO2 from ilmenite is by solubilizing both the Fe and Ti elements in HCl and then immediately hydrolyze the Ti. The leaching of low-grade ilmenite (ground to 0.177-0.149 mm) is studied kinetically by HCl in a stirred reactor. The research was conducted using the caustic fusion method followed by HCl leaching. The leaching reaction kinetics at the optimum conditions are analyzed using response surface methodology (RSM) with a second-order polynomial equation model and SSE with the shrinking core model (SCM). The results showed that HCl concentration and leaching time were directly proportional to the leached titanium concentration. In contrast, the leaching temperature was inversely proportional. The optimum operating conditions were obtained at a temperature of 30 °C, 9 M HCl, and 120 min of leaching time. The shrinking core model is a better representation of the kinetics than RSM with a second-order polynomial equation model. Based on SCM, the rate of the leaching reaction of titanium from low-grade ilmenite is controlled by diffusion through the ash layer.
Chemotaxonomic Relationship of Oligomer Resveratrol in Three Malaysian Dipterocarpus Species from the Taxonomic Tribe of Dipterocarpaceae
Authors: Nawi Liliwirianis , Zain Wan Zuraida Wan Mohd , Ahmat Norizan , Osman Che Puteh , Takaya Yoshiaki , Kamarozaman Aisyah Salihah , Adnan Noorazlina , Azahar Siti Zakirah
Published: June 2024

A phytochemical investigation of three species of Malaysian Dipterocarpus contributed to the isolation of 22 compounds which consist of 15 oligostilbenoids, 2 terpenes, 2 coumarins, and 3 flavonoids. The isolation of flavonoids in the Dipterocarpaceae family is very limited. Moreover, 4-methoxepigallocatechin-3-O-O-(3-methyl) gallate (20) was isolated for the first time in the plant. The occurrence of 4-O-methylgallocatechin (18) and its stereoisomer; 4-O’-methylepigallocatechin (19) was first reported in the Dipterocarpaceae family. This study also reported the existence of several types of oligostilbenoids such as davidiol A (8), stenophyllol B (9), isohopeaphenol (11), resveratrol (1), and ampelopsin E (10) which are the first occurrence in Dipterocarpus genus and suggested a significant chemotaxonomic relationship between Dipterocarpus, more closely to Vatica which is classified under Dipterocarpeae tribe.
Characterization and Application of Natural Photosensitizer and Poly(vinylidene Fluoride) Nanofiber Membranes-Based Electrolytes in DSSC
Authors: Zakiyah Nafisatus , Kusumawati Nita , Setiarso Pirim , Muslim Supari , A'yun Qurrota , Putri Marinda Mayliansarisyah
Published: June 2024

This comprehensive research has explored the potential of enhancing dye-sensitized solar cells (DSSC) by harnessing environmentally friendly natural dyes, such as chlorophyll pigments from pandanus (664.1 nm) and papaya leaves (664.0 nm), as well as betacyanin pigments from sappan-mangosteen (536.2 nm). Electrochemical analyses elucidated the energy band gaps, revealing a hierarchy with the smallest band gap observed for papaya leaves (1.387 eV), followed closely by sappan-mangosteen (1.389 eV) and pandan leaves (1.396 eV). This research effectively addressed the persistent issue of electrolyte leakage in DSSC development by introducing a polymer electrolyte derived from polyvinylidene fluoride (PVDF) through electrospinning and phase inversion techniques. SEM characterization results and thermogravimetric analysis underscored the superior characteristics and high thermal stability of the PVDF nanofiber polymer for DSSC applications. The study's pivotal findings underscore the remarkable DSSC performance achieved with chlorophyll pigment from papaya leaves, reaching 1.31% efficiency without a polymer electrolyte. Moreover, the sappan-mangosteen dye emerged as a promising contender with the highest efficiency values when applied with polymer electrolyte, recording rates of 1.17% for PVDF NF and 0.95% for PVDF, which are notably comparable to the efficiency of liquid electrolyte at 1.26%.
Chromatographic and Spectrophotometric Determination of Clindamycin in Pharmaceutical Products
Authors: Al-Momani Idrees Faleh , Al-Kilani Lana Mohammad Zaid
Published: June 2024

Accurate, precise, and reliable chromatographic and spectrophotometric methods were developed for determining clindamycin (CLD) in pharmaceutical formulations. The spectrophotometric method was adopted for flow injection analysis (FIA). The method is based on the online oxidation of CLD and measuring the absorbance of the resulting product using a flow cell at 605 nm. Experimental conditions, including FIA variables and reaction conditions, were optimized. The chromatographic separation was achieved using a C8 column and an isocratic mobile phase. The composition of the mobile phase selected for the analysis consists of a mixture of phosphate buffer (50%), MeOH (35%), and ACN (15%), adjusted to a pH of 3.47 by phosphoric acid. The eluent was monitored with a UV detector at 205 nm. The linearity range was 10–200 and 50–800 µg/mL for the FIA and HPLC, respectively. The applicability of the FIA and HPLC methods was validated by analyzing CLD in synthetic and commercial pharmaceutical products. No significant interferences were observed from the common excipients usually used in commercial formulations.
The Potential Perspective of Processing Rice Husk as SiO2 Source to Tetraalkoxysilane in Indonesia
Authors: Wahyudianto Benny , Putro Wahyu Saptrio , Nguyen Thuy Thi Hong , Fukaya Norihisa , Kataoka Sho
Published: June 2024

Tetra-alkoxysilane (TROS) is one of the useful chemicals and it can be processed to produce semiconductor and photovoltaic devices. Now, the transformation of silica (SiO2) to TROS is garnering interest due to the potential of extracting it from biomass. As the 14th largest country, Indonesia possesses an abundant source of SiO2 from mining activities and agricultural waste, notably rice husk (RH). However, only a little concrete action is planned for leveraging RH into a more valuable industrial substance. This review will explain two routes for TROS—conventional and direct—comparing their respective benefits and drawbacks. Additionally, it presents a simulation of various scenarios for scaling TROS production to an industrial level, considering technoeconomic and environmental assessment aspects. The focus then shifts to Indonesia’s strategic trajectory for 2045, offering recommendations to enhance resource utilization for economic and national development.
Analisis Penentuan Prioritas Pengembangan Unsur Pendukung Desa Wisata di Dewa Leuwilaja, Kecamatan Sindangwangi, Kabupaten Majalengka
Authors: Sri Rum Giyarsih  , Evi Wulandari
Published: June 2024

Seiring dengan berkembangnya zaman, sektor pariwisata khususnya desa wisata semakin berkembang dan menjadi bintang baru bagi perekonomian suatu wilayah. Desa Leuwilaja yang berada di Kecamatan Sindangwangi, Kabupaten Majalengka, Provinsi Jawa Barat memiliki potensi sumber daya ekonomi lokal berupa sentra kerajinan rotan yang dapat dikembangkan sebagai desa wisata rotan. Pemerintah desa maupun masyarakat memiliki keinginan untuk mengembangan desa wisata rotan sebagai wadah perekonomian masyarakat. Perlu adanya rencana program prioritas utama dalam pengembangan desa wisata untuk memudahkan stakeholder, baik pemerintah maupun masyarakat dalam melakukan pengembangan desa wisata. Analisis ini menjadi disusun sebagai bentuk pengabdian kepada masyarakat melalui kegiatan KKN-PPM UGM 2023 dengan tujuan untuk membantu dalam mengidentifikasi unsur pendukung dan strategi yang dapat diterapkan untuk mengoptimalkan potensi yang ada untuk pengembangan desa wisata.  Analisis ini menggunakan pendekatan deskriptif kualitatif dengan metode pengumpulan data berupa wawancara, dokumentasi, observasi lapangan, dan dilanjutkan dengan pemetaan usaha rotan untuk mendukung hasil observasi lapangan. Sedangkan teknik analisis data yang dilakukan adalah analisis SWOT untuk menentukan strategi pengembangan desa wisata. Hasil penelitian menunjukkan bahwa unsur pendukung wisata yang berada di Desa Leuwilaja, baik dari aspek amenitas dan aksesibilitas sudah cukup optimal dalam mendukung adanya desa wisata, tetapi untuk kelembagan masih perlu ditingkatkan kembali karena masih kurangnya pengelolaan potensi wisata. Hal yang menjadi prioritas untuk dikembangkan terlebih dahulu guna mendukung pengembangan desa wisata di Desa Leuwilaja adalah mengembangkan atraksi baru, mengembangkan skill sumber daya manusia dalam membuat inovasi baru, mengoptimalkan fasilitas umum, pengembangan infrastruktur dan spatial planning, dan meningkatkan kerjasama dengan berbagai pihak luar.
Swadaya Masyarakat: Implementasi Metode Takakura dalam Pengelolaan Sampah Organik di Kampung Purbonegaran, Yogyakarta
Authors: Ambar Teguh Sulistiyani  , Shafa Sannishara  , Dimas Bherlyano Ekarezky Rindingpadang  , Miladiyatu Tsania Zulfa
Published: June 2024

Waste management is a serious issue, particularly in densely populated urban areas like Yogyakarta City. This study aims to analyze community-driven self-help programs through the Takakura method application, using a participatory action research approach in the management of organik waste in Kampung Purbonegaran, Yogyakarta. The full capacity of the final disposal site (TPA) Piyungan prompted the city government to implement limits on waste accumulation through several regulations. This situation highlights the importance of waste management innovation, one of which is Takakura. The Takakura composting method is presented as a form of organic waste processing innovation by centralizing waste-decomposing fermentation that prevents unpleasant odors. The research was conducted by the KKN-PPM team from Universitas Gadjah Mada through socialization and an action program for creating composters in Kampung Purbonegaran. The implementation results showed high interest and participation from the community of Kampung Purbonegaran. The self-provision of Takakura Baskets was done by 35 people out of 40 members, or reaching 80.7% of PKK members. This initiative fostered gradual social change through cognitive understanding, embedding affective awareness, forming psychomotor skills, and the spirit of behavioral change conatively. This form of social change facilitated the adoption of the Takakura method in the processing of organik waste among 35 PKK members representing the heads of families. The success of this program contributes to achieving the Sustainable Development Goals (SDGs) for environmental preservation.
Analisis Potensi dan Permasalahan Pariwisata Berbasis Community-Based Tourism di Wilayah Jolosutro, Desa Srimulyo, Kecamatan Piyungan, Kabupaten Bantul, Daerah Istimewa Yogyakarta
Authors: Faiz Rahmatullah Nugroho  , Yutia Cesarinda Kusumawati  , Adinda Putri  , Alfiana Amrin Rosyadi
Published: June 2024

Jolosutro merupakan salah satu padukuhan di Kecamatan Piyungan, Kabupaten Bantul yang memiliki potensi pengembangan wisata. Potensi tersebut dikarenakan kawasan Jolosutro berkaitan erat dengan sejarah Sunan Geseng, situs peninggalannya, aktivitas kebudayaan, dan gastronomi lokal. Penelitian ini bertujuan untuk menganalisis potensi dan permasalahan dalam perencanaan pariwisata berbasis komunitas atau yang dikenal dengan Community-Based Tourism (CBT) di Jolosutro. Penelitian ini menggunakan metode deskriptif kualitatif melalui observasi, dokumentasi, dan focus group discussion yang dihimpun dalam bentuk kegiatan Napak Tilas. Napak Tilas Sunan Geseng dilakukan bersama dengan masyarakat setempat, kelompok sadar wisata (Pokdarwis), Pemerintah Desa Srimulyo, dan tim KKN-PPM UGM 2023. Kegiatan ini dipilih untuk dikembangkan karena beberapa alasan, yaitu mampu mengimplementasikan konsep CBT, menjaga keberlangsungan kearifan lokal, berpeluang untuk menghadirkan wisata berbasis pengalaman (experiential tourism) kepada wisatawan, dan berpotensi memberikan kesejahteraan ekonomi bagi masyarakat. Namun begitu, berdasarkan analisis Strength, Weakness, Opportunity, dan Threat (SWOT) masih diperlukan beberapa pengembangan dari wisata ini meliputi permasalahan akses jalan, fasilitas penunjang di tiap situs, serta perawatan dan pengembangan situs yang ada.
Menginspirasi Kesehatan Generasi Muda melalui Posyandu Remaja
Authors: Cahyo Wulandari  , Salsabila Riesputi  , Rahmafari Fikra Maulida  , Muhammad Asyam Fawwaz  , Indira Rahmawati
Published: June 2024

Masa remaja adalah fase kritis kehidupan yang ditandai dengan perubahan fisik, emosional, dan psikologis yang cepat. Posyandu Remaja merupakan program kesehatan berbasis masyarakat yang menyasar remaja. Program ini mendapatkan perhatian karena potensinya untuk mengatasi berbagai masalah kesehatan dan isu-isu remaja. Artikel ini bertujuan untuk memberikan gambaran tentang  Posyandu Remaja yang telah konsisten dilaksanakan di Desa Tempel dan Desa Wedung, Demak, Jawa Tengah dan memberikan gambaran kesehatan remaja di daerah tersebut. Hal ini menjadi topik yang menarik karena belum semua provinsi memiliki kegiatan Posyandu Remaja rutin. Teknik pengumpulan data dilakukan melalui wawancara kualitatif kepada bidan dari masing-masing desa mengenai posyandu remaja dan juga pemeriksaan kesehatan seperti pemeriksaan antropometri, tekanan darah, dan HB (hemoglobin) sebagai bagian dari kegiatan posyandu remaja dan memberikan gambaran mengenai kesehatan remaja di daerah tersebut. Wawancara yang dilakukan menyelidiki perspektif bidan mengenai dampak program, kekuatan yang dimiliki, tantangan yang dihadapi, serta perbaikan yang telah maupun akan dilakukan. Pengamatan permasalah kesehatan dan evaluasi dari Posyandu Remaja di setiap desa juga telah dilakukan selama kegiatan pengabdian masyarakat melalui intervensi kesehatan oleh tim KKN PPM UGM JT-133. Hasil studi ini menyoroti peran penting Posyandu Remaja dalam meningkatkan kesadaran kesehatan di kalangan remaja. Posyandu Remaja berfungsi sebagai sebuah wadah yang sangat berharga untuk meningkatkan pengetahuan kesehatan remaja, mendorong perubahan perilaku yang positif, dan menciptakan lingkungan masyarakat yang mendukung bagi remaja. Untuk memaksimalkan dampaknya, kegiatan di Posyandu Remaja dibuat bervariasi. Selain pemeriksaan dan edukasi kesehatan, kegiatan yang dapat meningkatkan soft skill atau keterampilan seni di kalangan remaja juga telah dilakukan. Dengan demikian remaja dapat mengembangkan rasa percaya diri, kecakapan, keterampilan, dan menjadi sehat jasmani rohani. Pendekatan holistik terhadap posyandu remaja akan berpotensi membentuk generasi muda yang lebih sehat, berpengetahuan luas, serta menjadi dasar untuk peningkatan kesehatan masyarakat secara keseluruhan dan dalam jangka panjang.
Pengembangan Sentra Produksi Kain Tenun Tedunan sebagai Upaya Membangun Perekonomian Desa Tedunan yang Berkelanjutan
Authors: Cahyo Wulandari  , Matus Hanun Az Zahra
Published: June 2024

Desa Tedunan merupakan salah satu desa penghasil kain tenun di Indonesia. Kain tenun merupakan salah satu produk tekstil yang termasuk ke dalam warisan budaya tak benda asli Indonesia. Selain mengandung nilai kearifan budaya lokal, kain tenun juga memiliki nilai ekonomi tinggi sebagai produk ekspor unggulan Indonesia. Namun, dibalik potensi keindahannya, ternyata bisnis kain Tenun Tedunan berada dalam masalah cukup serius. Salah satu isu terberat dalam pengembangan bisnis tenun ini adalah adanya tren produk fast fashion. Adanya tren fast fashion ini berdampak pada menurunnya minat masyarakat Indonesia untuk membeli produk-produk pakaian lokal seperti tenun dan batik. Selain itu, berkembangnya pabrik garment dan tekstil di sekitar Desa Tedunan, juga menjadi salah satu isu penyebab berkurangnya minat pemuda untuk menjadi pengrajin tenun. Jika hal ini terus dibiarkan, maka potensi kain tenun akan punah karena tidak adanya regenerasi pengrajin tenun. Oleh karena itu, adanya program penelitian dan pengabdian ini bertujuan untuk membantu para pengrajin kain Tenun Tedunan dalam mengembangangkan bisnisnya. Selain itu, program ini bertujuan untuk memberikan analisis serta rekomendasi dalam membangun bisnis kain Tenun Tedunan dengan mendayagunakan seluruh pihak agar tercapai sinergi dan kolaborasi sebagai upaya mencapai perekonomian Desa Tedunan yang berkelanjutan. Pengambilan data dalam penelitian ini dilakukan dengan observasi dan wawancara mendalam kepada para pengrajin Tenun Tedunan dan perangkat desa untuk mencari tahu akar permasalahan yang ada. Secara garis besar, terdapat empat permasalahan utama dari bisnis kain Tenun Tedunan ini, yaitu permodalan, produksi, pemasaran, dan regenerasi. Oleh karena itu, program pengabdian ini difokuskan untuk menjawab semua permasalahan yang ada, seperti program sosialisasi pemetaan potensi dan masalah bisnis Tenun Tedunan, penyusunan roadmap rekomendasi kebijakan pembangunan bisni tenun, program pembuatan video dokumenter, dan sosialisasi pemasaran digital. Seluruh program ini mampu memberikan wawasan kepada masyarakat mengenai langkah-langkah mengembangkan bisnis kain Tenun Tedunan agar menjadi produk lokal unggulan yang dapat memberikan kontribusi ekonomi jangka panjang.
Pelatihan Tari Dolalak sebagai Upaya Pemenuhan Children Subjective Well Being pada Anak-Anak di Desa Awu-Awu, Kecamatan Ngombol, Kabupaten Purworejo
Authors: Adinda Putri  , Faiz Rahmatullah Nugroho  , Susilo Andi Darma
Published: June 2024

Tari Dolalak merupakan kesenian rakyat Purworejo yang berupa perpaduan dari gerakan tari, musik karawitan, dan vokal (koor) yang dapat ditarikan baik oleh laki-laki maupun perempuan secara berkelompok dan berpasangan. Tim Kuliah Kerja Nyata-Pembelajaran Pemberdayaan Masyarakat Universitas Gadjah Mada (KKN-PPM UGM) mendapatkan temuan menarik bahwa anak-anak Sekolah Dasar Negeri (SDN) Awu-Awu punya keinginan untuk berlatih Tari Dolalak. Namun, ada keterbatasan akses yang dihadapi karena pihak sekolah kesulitan untuk menyelenggarakan ekstrakurikuler. Oleh karena itu, Tim KKN-PPM UGM mencoba untuk memfasilitasi keinginan anak-anak dengan cara bermitra dengan Sanggar Tari Tut Wuri karena tarian merupakan salah satu pemenuhan ekspresi dan dapat berpengaruh terhadap Subjective Well Being. Penelitian ini menggunakan metode deskriptif kualitatif dan menggunakan analisis deskriptif berdasarkan komponen dalam Children Subjective Well Being untuk menganalisis data, yaitu ragam pengalaman yang meliputi emosi positif, emosi negatif, kepuasan terhadap subjek tertentu, dan kepuasan hidup secara menyeluruh. Menari Tari Dolalak dapat menjadi sarana anak untuk memahami emosi positif dan negatif seperti senang, nyaman, berani tampil, sedih, kecewa, dan marah; lalu mereka dapat menjalin hubungan pertemanan yang suportif dan komunikatif, baik dengan sebaya maupun dengan pelatih dan tim KKN-PPM UGM. Melalui latihan tari anak-anak mampu untuk mulai memetakan dan menemukan kebutuhan/minat dalam hidupnya.
Supervisory Justice, Trust in Supervisors and Employee Creativity: The Mediating Role of Self-Efficacy
Authors: Deng Xudong , Zheng Yuan , Jin Yuanshi
Published: June 2024

This study examines the relationship between supervisory impartiality, trust in supervisors, and employee creativity within financial enterprises. These factors significantly influence employee morale and efficiency. Our research aims to provide actionable recommendations for optimizing enterprise management through theoretical insights. We first investigate the impact of supervisory justice on employees’ trust in their superiors, finding that fair supervision enhances trust, which in turn boosts employees’ confidence and efficiency at work. Employee creativity is crucial for achieving organizational goals; fostering creativity can lead to more efficient business operations and improved management practices. A key focus of our research is the mediating role of self-efficacy, defined as an employee’s belief in their ability to successfully complete tasks. We explore how self-efficacy bridges the gap between supervisory impartiality, trust in supervisors, and employee creativity. Our findings suggest that a just work environment provided by supervisors enhances employees’ self-efficacy, resulting in greater confidence and a willingness to engage in creative work. In summary, this study explores these relationships within financial firms. By understanding these dynamics, companies can create a fair work environment, enhancing employee satisfaction and efficiency. We recommend that enterprise managers foster a just supervisory environment to boost employees’ self-efficacy and support the achievement of corporate goals.
Phantom Limn
Authors: Bennett Stuart
Published: June 2024

The output was an exhibition at Dovecot Gallery, Edinburgh, 6 – 10 July 2017. It was the result of a one-week group residency at the gallery, conceived as an experimental, collaborative practice based research inquiry into drawing as a method of thinking. The residency brought together eight international, university-based artists: Stuart Bennett (University of Edinburgh), Dean Hughes (Northumbria University), David Mackintosh (University of Central Lancashire), Kelly Chorpening (University of the Arts London), Rebecca Fortnum (Royal College of Art), Chloe Briggs (Paris College of Art), Mark Nagtzaam (Sint Lucas, Antwerp) and Veronique Devoldere (Paris College of Art). The research interrogated the nature of drawing as a form of enquiry, observational tool and end in itself. It also explored the idea of a collective work. The artists – all teachers of drawing within different University settings – were particularly interested in exploring instructions for drawing as a means of prompting reflection on the often implicit values entailed in the pedagogy of drawing. The residency was presented as a live studio environment, structured to encourage public engagement, and this semi-public, collective and participatory nature of the research space sought in part to recreate the environment of the art school. The gallery was used as studio, a conference room, a social space and an exhibition space. The artists designed, and Bennett constructed, a large scale, flexible framework that received the collaborative work as it was made, and functioned as the focus for dialogue and public engagement.
Seven Songs for a Long Life
Authors: Hardie Amy
Published: June 2024

Seven Songs for a Long Life is a documentary film that resulted from an interdisciplinary creative collaboration between the documentary film-maker Amy Hardie, medical and health care professionals and patients at the end of life. When the research project began in 2011, the UK health system was based on a medical model emphasising a disease-led approach to care. Challenging this model, and working with patients, families and staff, Hardie explored documentary interventions in palliative care in Strathcarron hospice in Scotland. Hardie worked with 15 families to make films in an iterative process that included reflective listening and screenings. These films were, variously: legacies, made for those facing bereavement; portraits taking stock of patient life stories; play spaces, expressing parts of themselves that get submerged in the problem-solving ethos of dealing with illness; and unspoken observations where families used the camera to communicate emotions hard to express in words. Between 2013 and 2018, demand by UK palliative care policy makers grew for these short films which screened, for instance, to an audience of 2,500 at ‘Building Bridges’ conference in London, at ‘Changing Capacities’ in Liverpool, and ‘World Congress of European association of Palliative Care’ in Prague. The participation of patients and staff continued as Hardie directed the final feature documentary, (supported by UK and international funding of £302k), and designed post-screening workshops. These deepened audience engagement with the themes of the film, i.e. values at end of life, capacity of carers, and fear of mortality, developing into seminars for health professionals and NHS policy makers. The cinema feature premiered in October 2015 in Scotland, and was then bought by 8 countries and distributed by Argot Pictures and Cargo in the USA.