bluuebunny/crossref_metadata_2025 huggingface dataset:
Removal Behavior of Methylene Blue from Aqueous Solution by Tea Waste: Kinetics, Isotherms and Mechanism
Authors: Liu Li , Fan Shisuo , Li Yang
Published: June 2018

Tea waste (biosorbent) was characterized by BET, SEM, FTIR, XPS, solid state 13C-NMR and applied to remove methylene blue (MB) from aqueous solution. The effect of different factors on MB removal, kinetics, isotherms and potential mechanism was investigated. The results showed that tea waste contains multiple organic functional groups. The optimum solid-to-liquid ratio for MB adsorption was 4.0 g·L−1 and the initial pH of the MB solution did not need to be adjusted to a certain value. The pseudo-second-order model could well fit the adsorption kinetic process. The adsorption process could be divided into two stages: a fast adsorption stage and a slow adsorption stage. The adsorption isotherm could be well described by Langmuir and Temkin isotherm models. The maximum adsorption amount could reach 113.1461 mg·g−1 based on Langmuir isotherm fitting. Desorption and reusability experiments showed that MB adsorption onto tea waste could be stable and could not cause secondary pollution. The interaction mechanism between tea waste and MB involved electrostatic attraction, hydrogen bond, ion exchange, π-π binding. The organic functional groups of tea waste played an important role during the MB removal process. Therefore, tea waste has the potential to act as an adsorbent to remove MB from aqueous solution.
Distribution Pattern of Red Fox (Vulpes vulpes) Dens and Spatial Relationships with Sea Turtle Nests, Recreation, and Environmental Characteristics
Authors: Halls Joanne N. , Hill Jeffery M. , Urbanek Rachael E. , Sutton Hope
Published: June 2018

Although sea turtles are formidable prey as adults, their nests are highly vulnerable to terrestrial predation. Along the Southeastern coast of the United States, a primary predator of sea turtle nests is the red fox (Vulpes vulpes). Examining the relationship between fox populations and nest predation is often difficult due to coastal development. Masonboro Island, North Carolina is an undeveloped, natural, 13-km-long barrier island complex that is a component of the North Carolina National Estuarine Research Reserve (NERR). Masonboro Island consists of beaches, a dune ridge, back barrier flats, an expansive salt marsh, a lagoon, and spoil islands seaward of the Intracoastal Waterway. A field survey, which was conducted each spring from 2009 through 2012, recorded den entrance coordinates based upon recent use by foxes. Sea turtle nests were located using a similar survey methodology, which identifies viable and predated nests as well as false crawls. A series of spatial-temporal pattern analysis techniques were used to identify trends through time. The results indicated that: (1) fox den entrances and predated sea turtle nests were clustered throughout the island (p = 0.01); (2) den entrances in the northern part of the island were closer to the sea turtle nests than other locations on the island; (3) fox den entrances were positively correlated (p = 0.01) with dune height, (4) fox den entrances were located closer to the island boat access sites than expected (p = 0.01). A variety of spatial sensitivity tests were used to test the validity of the statistically significant cluster analyses. A Geographically Weighted Regression model was created to predict the location of fox dens using dune elevation, the distance to predated sea turtle nests, and the distance to boat access sites. The model accounted for 40% of the variance and had a small residual error, which indicates that the independent variables were statistically valid. Results from this project will be used by the NC NERR staff to develop management plans and to further study fox-related impacts on the island. For example, given the higher density of fox den entrances on the northern part of the island, managers may consider targeted wildlife control measures during the sea turtle nesting season to diminish predation.
Spatial Characterization and Mapping of Gated Communities
Authors: Silva de Araujo Agnes , Pereira de Queiroz Alfredo
Published: June 2018

The increase in gated communities is the most important recent urban phenomenon in Latin America. This article proposes a methodology to identify the morphological features and spatial characteristics of gated communities to map them based on the land cover map and the quality of life index. The importance of this proposal is related to the fact that there are no official statistics on gated communities in most Latin American countries. The proposal was tested in Marília, a medium-sized city in southeastern Brazil. Geographic object-based image analysis with high-resolution satellite images and 2010 demographic census variables were used to support the research procedures. The accuracy of the output was 83.3%. It was found that there is a positive correlation between the quality of life index and the occurrence of high-standard gated communities (golden ghettos). They were mainly identified by the following land cover classes: white painted concrete slabs/light-colored roof tiles, and the existence of pavement, pools, and herbaceous vegetation. In addition to mapping the gated communities, it was possible to classify them according to the categories proposed in the literature (golden ghettos and lifestyle gated communities).
N-3 Polyunsatured Fatty Acids in Menopausal Transition: A Systematic Review of Depressive and Cognitive Disorders with Accompanying Vasomotor Symptoms
Authors: Ciappolino Valentina , Mazzocchi Alessandra , Enrico Paolo , Syrén Marie-Louise , Delvecchio Giuseppe , Agostoni Carlo , Brambilla Paolo
Published: June 2018

Depression is one of the most important health problems worldwide. Women are 2.5 times more likely to experience major depression than men. Evidence suggests that some women might experience an increased risk for developing depression during “windows of vulnerability”, i.e., when exposed to intense hormone fluctuations, such as the menopause transition. Indeed, this period is associated with different symptoms, including vasomotor, depressive, and cognitive symptoms, which have all been shown to worsen as women approach menopause. Even though hormonal therapy represents the most effective treatment, side effects have been reported by several studies. Therefore, an increased number of women might prefer the use of alternative medicine for treating menopausal symptoms. N-3 long-chain polyunsaturated fatty acids (n-3 LCPUFAs) are included among these alternative treatments. We here provide a review of studies investigating the effects of n-3 LCPUFAs on hot flashes and depressive and cognitive disorders in menopausal women. The reported results are scattered and heterogeneous. In conclusion, a beneficial role of n-3 LCPUFAs in hot flashes, and depressive and cognitive symptoms related to menopausal transition is still far from conclusive.
Evolutionary History of the Glycoside Hydrolase 3 (GH3) Family Based on the Sequenced Genomes of 48 Plants and Identification of Jasmonic Acid-Related GH3 Proteins in Solanum tuberosum
Authors: Zhang Chao , Zhang Leilei , Wang Dongdong , Ma Haoli , Liu Bailin , Shi Zheng , Ma Xiaohui , Chen Yue , Chen Qin
Published: June 2018

Glycoside Hydrolase 3 (GH3) is a phytohormone-responsive family of proteins found in many plant species. These proteins contribute to the biological activity of indolacetic acid (IAA), jasmonic acid (JA), and salicylic acid (SA). They also affect plant growth and developmental processes as well as some types of stress. In this study, GH3 genes were identified in 48 plant species, including algae, mosses, ferns, gymnosperms, and angiosperms. No GH3 representative protein was found in algae, but we identified 4 genes in mosses, 19 in ferns, 7 in gymnosperms, and several in angiosperms. The results showed that GH3 proteins are mainly present in seed plants. Phylogenetic analysis of all GH3 proteins showed three separate clades. Group I was related to JA adenylation, group II was related to IAA adenylation, and group III was separated from group II, but its function was not clear. The structure of the GH3 proteins indicated highly conserved sequences in the plant kingdom. The analysis of JA adenylation in relation to gene expression of GH3 in potato (Solanum tuberosum) showed that StGH3.12 greatly responded to methyl jasmonate (MeJA) treatment. The expression levels of StGH3.1, StGH3.11, and StGH3.12 were higher in the potato flowers, and StGH3.11 expression was also higher in the stolon. Our research revealed the evolution of the GH3 family, which is useful for studying the precise function of GH3 proteins related to JA adenylation in S. tuberosum when the plants are developing and under biotic stress.
Identification of an Actionable Mutation of KIT in a Case of Extraskeletal Myxoid Chondrosarcoma
Authors: Urbini Milena , Indio Valentina , Astolfi Annalisa , Tarantino Giuseppe , Renne Salvatore Lorenzo , Pilotti Silvana , Dei Tos Angelo Paolo , Maestro Roberta , Collini Paola , Nannini Margherita , Saponara Maristella , Murrone Ludovica , Dagrada Gian Paolo , Colombo Chiara , Gronchi Alessandro , Pession Andrea , Casali Paolo Giovanni , Stacchiotti Silvia , Pantaleo Maria Abbondanza
Published: June 2018

Extraskeletal myxoid chondrosarcoma (EMC) is an extremely rare soft tissue sarcoma, marked by a translocation involving the NR4A3 gene. EMC is usually indolent and moderately sensitive to anthracycline-based chemotherapy. Recently, we reported on the therapeutic activity of sunitinib in a series of EMC cases, however the molecular target of sunitinib in EMC is unknown. Moreover, there is still the need to identify alternative therapeutic strategies. To better characterize this disease, we performed whole transcriptome sequencing in five EMC cases. Peculiarly, in one sample, an in-frame deletion (c.1735_1737delGAT p.D579del) was identified in exon 11 of KIT. The deletion was somatic and heterozygous and was validated both at DNA and mRNA level. This sample showed a marked high expression of KIT at the mRNA level and a mild phosphorylation of the receptor. Sanger sequencing of KIT in additional 15 Formalin Fixed Paraffin Embedded (FFPE) EMC did not show any other mutated cases. In conclusion, exon 11 KIT mutation was detected only in one out of 20 EMC cases analyzed, indicating that KIT alteration is not a recurrent event in these tumors and cannot explain the EMC sensitivity to sunitinib, although it is an actionable mutation in the individual case in which it has been identified.
Boldine Improves Kidney Damage in the Goldblatt 2K1C Model Avoiding the Increase in TGF-β
Authors: Gómez Gonzalo , Velarde Victoria
Published: June 2018

Boldine, a major aporphine alkaloid found in the Chilean boldo tree, is a potent antioxidant. Oxidative stress plays a detrimental role in the pathogenesis of kidney damage in renovascular hypertension (RVH). The activation of the renin-angiotensin system (RAS) is crucial to the development and progression of hypertensive renal damage and TGF-β is closely associated with the activation of RAS. In the present study, we assessed the effect of boldine on the progression of kidney disease using the 2K1C hypertension model and identifying mediators in the RAS, such as TGF-β, that could be modulated by this alkaloid. Toward this hypothesis, rats (n = 5/group) were treated with boldine (50 mg/kg/day, gavage) for six weeks after 2K1C surgery (pressure ≥ 180 mmHg). Kidney function was evaluated by measuring of proteinuria/creatininuria ratio (U prot/U Crea), oxidative stress (OS) by measuring thiobarbituric acid reactive substances (TBARS). The evolution of systolic blood pressure (SBP) was followed weekly. Alpha-smooth muscle actin (α-SMA) and Col III were used as markers of kidney damage; ED-1 and osteopontin (OPN) were used as markers of inflammation. We also explored the effect in RAS mediators, such as ACE-1 and TGF-β. Boldine treatment reduced the UProt/UCrea ratio, plasma TBARS, and slightly reduced SBP in 2K1C hypertensive rats, producing no effect in control animals. In 2K1C rats treated with boldine the levels of α-SMA, Col III, ED-1, and OPN were lower when compared to 2K1C rats. Boldine prevented the increase in ACE-1 and TGF-β in 2K1C rats, suggesting that boldine reduces kidney damage. These results suggest that boldine could potentially be used as a nutraceutic.
Fluorinated Graphene Prepared by Direct Fluorination of N, O-Doped Graphene Aerogel at Different Temperatures for Lithium Primary Batteries
Authors: Bi Xu , Li Yanyan , Qiu Zhipeng , Liu Chao , Zhou Tong , Zhuo Shuping , Zhou Jin
Published: June 2018

Fluorinated graphene (FG) has been a star material as a new derivative of graphene. In this paper, a series of fluorinated graphene materials are prepared by using N, O-doped graphene aerogel as precursor via a direct fluorination method, and the effect of fluorination temperature on the FG structure is investigated. The prepared FG samples are systematically characterized by scanning and transmission electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and Raman spectroscopy. It is found that the structure of FG, including features such as layer size, chemical composition, chemical bond state of the component elements, etc., is significantly related to the fluorination temperature. With the change of the fluorination temperature, fluorine atoms enter the graphene framework by a substitution process of the N, O-containing groups, including residual phenol, ether, carbonyl groups, or C–N groups, and the addition to CC bonds, subsequently forming a fluoride with different fluorine contents. The fluorine content increases as the fluorination temperature increases from 200 °C to 300 °C, but decreases at a fluorination temperature of 350 °C due to the decomposition of the fluorinated graphene. The prepared FG samples are used as cathode material for lithium primary batteries. The FG sample prepared at 300 °C gives a high specific capacity of 632 mAh g−1 and a discharge plateau of 2.35 V at a current density of 10 mA g−1, corresponding to a high energy density of 1485 Wh kg−1.
The Positive Role of Curcumin-Loaded Salmon Nanoliposomes on the Culture of Primary Cortical Neurons
Authors: Hasan Mahmoud , Latifi Shahrzad , Kahn Cyril J.F. , Tamayol Ali , Habibey Rouhollah , Passeri Elodie , Linder Michel , Arab-Tehrany Elmira
Published: June 2018

Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and characterized its encapsulation efficiency and release profile. The proposed natural carriers increased the solubility and the bioavailability of curcumin. In addition, various physico-chemical properties of the developed soft nanocarriers with and without curcumin were studied. Nanoliposome-encapsulated curcumin increased the viability and network formation in the culture of primary cortical neurons and decreased the rate of apoptosis.
A Hetero-Photoautotrophic Two-Stage Cultivation Process for Production of Fucoxanthin by the Marine Diatom Nitzschia laevis
Authors: Lu Xue , Sun Han , Zhao Weiyang , Cheng Ka-Wing , Chen Feng , Liu Bin
Published: June 2018

There is currently much interest in fucoxanthin due to its broad beneficial health effects. The major commercial source of fucoxanthin is marine seaweed, which has many shortcomings, and has thus restricted its large-scale production and more diversified applications. In this study, growth characteristics and fucoxanthin accumulation were evaluated to explore the potential of the marine diatom Nitzschia laevis in fucoxanthin production. The results suggested that heterotrophic culture was more effective for cell growth, while the mixotrophic culture was favorable for fucoxanthin accumulation. A two-stage culture strategy was consequently established. A model of exponential fed-batch culture led to a biomass concentration of 17.25 g/L. A mix of white and blue light significantly increased fucoxanthin content. These outcomes were translated into a superior fucoxanthin productivity of 16.5 mg/(L·d), which was more than 2-fold of the best value reported thus far. The culture method established herein therefore represents a promising strategy to boost fucoxanthin production in N. laevis, which might prove to be a valuable natural source of commercial fucoxanthin.
Monitoring changes in heart tissue temperature and evaluation of graft function after coronary artery bypass grafting surgery
Authors: Lekas Raimundas , Jakuška Povilas , Kriščiukaitis Algimantas , Veikutis Vincentas , Dzemyda Gintautas , Mickevičius Tomas , Morkūnaitė Kristina , Vilkė Alina , Treigys Povilas , Civinskienė Genuvaitė , Andriuškevičius Jonas , Vanagas Tomas , Skauminas Kęstutis , Bernatonienė Jurga
Published: June 2018

Thermography is a relatively new contact-free method used in experimental and clinical studies and in cardiovascular surgery to investigate the myocardium and coronary artery function. Objects of complex study included mongrel dogs and patients with coronary artery disease who underwent cardiac surgery. For active dynamic thermography, we used a thermovision camera “A20V” (FLIR Systems, USA). Our data indicate that both experimental and clinical study performed on beating hearts could be an important approach to interoperation inspection of autovenous graft function. An infrared camera also can be successfully used to determine the extent of ischemic damage to the myocardium, heart, and blood vessels during surgery as a significant prognostic tool for evaluating outcome after cardiac operation.
Diagnostic value of multislice computed tomography coronary angiography in patients with left bundle branch block
Authors: Jankauskas Antanas , Zaveckienė Jurgita , Unikas Ramūnas , Šlapikas Rimvydas , Basevičius Algidas , Žaliūnas Remigijus
Published: June 2018

Objective. The aim of present study was to evaluate the diagnostic value of multislice computed tomography coronary angiography in patients with left bundle branch block. Materials and methods. Twenty-four patients who underwent both multislice computed tomography coronary angiography and invasive coronary angiography were enrolled in the study. Findings of these imaging modalities were compared in order to determine the sensitivity, specificity, positive predictive value, and negative predictive value of multislice computed tomography angiography in identifying hemodinamically significant stenoses (≥50%). All segments ≥2 mm in diameter were visually assessed independently from their degree of calcification and image quality. Results. In total, 328 segments were analyzed. The Spearman correlation coefficient between multislice computed tomography and invasive coronary angiography was 0.76 (P<0.0001). On a per-segment basis, sensitivity, specificity, positive predictive value, and negative predictive value of multislice computed tomography angiography were 75%, 97.7%, 72%, and 98%, respectively; on a per-vessel basis, these values were 77.8%, 92.3%, 70%, and 94.7%, respectively; on a per-patient basis – 81.8%, 84.6%, 81.8%, and 84.6%, respectively.Conclusions. Multislice computed tomography coronary angiography provides a high diagnostic accuracy in detecting significant coronary artery stenoses in patients with left bundle branch block.
Prevalence of drug use among students of vocational schools in Klaipėda city, Lithuania, in 2004–2006
Authors: Jurgaitienė Dalia , Zaborskis Apolinaras , Šumskas Linas
Published: June 2018

The aim was to evaluate the prevalence and trends of drug use among students of vocational schools in Klaipėda city and to establish the relationships between psychosocial factors and drug abuse. Participants and methods. Two cross-sectional questionnaire surveys were carried out among first-year students of vocational schools in Klaipėda. Random samples of 912 and 342 students aged 16–19 years (representatives of Western part of Lithuania) were questioned in 2004 and 2006, respectively. Questionnaires were filled out anonymously in the classroom. Questions have covered information on drugs such as marihuana, club drugs, injectable drugs, and other drugs. Logistic regression was used for evaluation of relationship between drug use and different psychosocial and behavioral determinants of drug use. Results. In 2004, 56.0% of male respondents and 42.0% of female respondents have reported any drug use during their life. The analysis of standardized data (by the place of residence) showed an increase in the prevalence of drug use during 2004–2006: up to 65.5% in boys (P<0.05) and up to 44.0% in girls (P>0.05). Percentage of club drug users increased significantly in girls (from 21.5% to 29.8%; P=0.040) and exceeded the level of boys. The average number of drugs of different types used by boys changed slightly from 1.57 to 1.63 (P>0.05), but increased significantly in girls (from 1.49 to 1.88, P<0.001). The use of drugs was related to school location (graduates of Klaipėda schools used drugs more frequently), communication with friends who use drugs, participation in the parties where drugs are used, alcohol use, and smoking. In 2006 survey, more significant relationship between drug use and social and behavioral factors was observed. Conclusion. Several indicators of drug use showed a significant increase in drug abuse among students of vocational schools in Klaipėda during the period of 2004–2006. Multisectorial efforts and integrated preventive measures should be applied for the prevention of epidemics of drug use in Klaipėda city.
Radiological changes after Nuss operation for pectus excavatum
Authors: Kilda Artūras , Lukoševičius Saulius , Barauskas Vidmantas , Jankauskaitė Živilė , Basevičius Algidas
Published: June 2018

The objective of this study was to evaluate sternovertebral distance and the chest wall deformation after Nuss procedure. Materials and methods. Anteroposterior and lateral chest radiographs were performed before Nuss procedure, 1, 6, and 12 months after operation and finally 1 month after bar removal. Sternovertebral distance and transversal chest dimension were measured on radiographs, as well as Haller and vertebral indexes were calculated. Results. A total of 84 children with funnel chest were operated on. Preoperative sternovertebral distance was 79.81±6.96 mm; 1 month after operation, 97.84±17.08 mm; 6 months, 110.55±13.85 mm; and 12 months, 113.6±14.61 mm. After removal of the bar, the distance was 105±11.95 mm. The mean increase in sternovertebral distance during the first month was 18 mm (P<0.0001); 1–6 months, 12.8 mm (P=0.0006); and 6-12 months, 3 mm (P=0.48). The mean decrease in sternovertebral distance after removal of the bar was 8.6 mm (P=0.47). The decrease in transversal chest dimension during the first month was significant (13.3±12.86 mm, P=0.012). Conclusions. The sternovertebral distance was significantly increased after Nuss operation. Restoration of deformation proceeds during all the first year after operation. The dynamics of deformation is better depicted by means of vertebral index rather than Haller index.
Stability, Electronic Structure, and Dehydrogenation Properties of Pristine and Doped 2D MgH2 by the First Principles Study
Authors: Gong Xu , Shao Xiaohong
Published: June 2018

Based on first principles calculations, we theoretically predict the new two-dimensional (2D) MgH2. The thermodynamic stability, partial density of states, electron localization function, and Bader charge of pure and the transition metal (Ti, V, and Mn) doped 2D MgH2 are investigated. The results show that all the systems are dynamically stable, and the dehydrogenation properties indicate that the decomposition temperature can be reduced by introducing the transition metal, and the Mn doped system exhibits good performance for better hydrogen storage and dehydrogenation kinetics.
Optimal Charge Planning Model of Steelmaking Based on Multi-Objective Evolutionary Algorithm
Authors: Yang Jianping , Wang Bailin , Zou Caoyun , Li Xiang , Li Tieke , Liu Qing
Published: June 2018

As having an important part of coordination control in steelmaking process, traditional production planning and scheduling technologies are developed with little consideration of the metallurgy mechanism, leading to lower feasibility for actual production. Based on current situation and requirements of steel plants, this paper focuses on the investigation of the charge plan from the view of metallurgy and establishes a charge planning model concerning the minimization of both the open order amount and the difference in due dates of the orders in each charge. A modified multi-objective evolutionary algorithm is proposed to solve the charge planning model of steelmaking process. By presenting a new fitness function, based on the rule of target ranking and introducing the Elitism strategy to construct the non-inferior solution set, the quality of solutions is improved effectively and the convergence of the algorithm is enhanced remarkably. Simulation experiments are carried out on the orders from actual production, and the proposed algorithm produces a group of optimized charge plans in a short time. The quality of the solutions is better than those produced by a genetic algorithm, modified partheno-genetic algorithm, and those produced manually to some extent. The simulation results demonstrate the feasibility and effectiveness of the proposed model and the algorithm.
Encapsulation of NEM Memory Switches for Monolithic-Three-Dimensional (M3D) CMOS–NEM Hybrid Circuits
Authors: Jo Hyun Chan , Choi Woo Young
Published: June 2018

Considering the isotropic release process of nanoelectromechanical systems (NEMSs), defining the active region of NEM memory switches is one of the most challenging process technologies for the implementation of monolithic-three-dimensional (M3D) CMOS–NEM hybrid circuits. In this paper, we propose a novel encapsulation method of NEM memory switches. It uses alumina (Al2O3) passivation layers which are fully compatible with the CMOS baseline process. The Al2O3 bottom passivation layer can protect intermetal dielectric (IMD) and metal interconnection layers from the vapor hydrogen fluoride (HF) etching process. Thus, the controllable formation of the cavity for the mechanical movement of NEM devices can be achieved without causing any damage to CMOS baseline circuits as well as metal interconnection lines. As a result, NEM memory switches can be located in any place and metal layer of an M3D CMOS–NEM hybrid chip, which makes circuit design easier and more volume efficient. The feasibility of our proposed method is verified based on experimental results.
Multiple and Periodic Measurement of RBC Aggregation and ESR in Parallel Microfluidic Channels under On-Off Blood Flow Control
Authors: Kang Yang Jun , Kim Byung Jun
Published: June 2018

Red blood cell (RBC) aggregation causes to alter hemodynamic behaviors at low flow-rate regions of post-capillary venules. Additionally, it is significantly elevated in inflammatory or pathophysiological conditions. In this study, multiple and periodic measurements of RBC aggregation and erythrocyte sedimentation rate (ESR) are suggested by sucking blood from a pipette tip into parallel microfluidic channels, and quantifying image intensity, especially through single experiment. Here, a microfluidic device was prepared from a master mold using the xurography technique rather than micro-electro-mechanical-system fabrication techniques. In order to consider variations of RBC aggregation in microfluidic channels due to continuous ESR in the conical pipette tip, two indices (aggregation index (AI) and erythrocyte-sedimentation-rate aggregation index (EAI)) are evaluated by using temporal variations of microscopic, image-based intensity. The proposed method is employed to evaluate the effect of hematocrit and dextran solution on RBC aggregation under continuous ESR in the conical pipette tip. As a result, EAI displays a significantly linear relationship with modified conventional ESR measurement obtained by quantifying time constants. In addition, EAI varies linearly within a specific concentration of dextran solution. In conclusion, the proposed method is able to measure RBC aggregation under continuous ESR in the conical pipette tip. Furthermore, the method provides multiple data of RBC aggregation and ESR through a single experiment. A future study will involve employing the proposed method to evaluate biophysical properties of blood samples collected from cardiovascular diseases.
Recent Advances in Tactile Sensing Technology
Authors: Park Minhoon , Bok Bo-Gyu , Ahn Jong-Hyun , Kim Min-Seok
Published: June 2018

Research on tactile sensing technology has been actively conducted in recent years to pave the way for the next generation of highly intelligent devices. Sophisticated tactile sensing technology has a broad range of potential applications in various fields including: (1) robotic systems with tactile sensors that are capable of situation recognition for high-risk tasks in hazardous environments; (2) tactile quality evaluation of consumer products in the cosmetic, automobile, and fabric industries that are used in everyday life; (3) robot-assisted surgery (RAS) to facilitate tactile interaction with the surgeon; and (4) artificial skin that features a sense of touch to help people with disabilities who suffer from loss of tactile sense. This review provides an overview of recent advances in tactile sensing technology, which is divided into three aspects: basic physiology associated with human tactile sensing, the requirements for the realization of viable tactile sensors, and new materials for tactile devices. In addition, the potential, hurdles, and major challenges of tactile sensing technology applications including artificial skin, medical devices, and analysis tools for human tactile perception are presented in detail. Finally, the review highlights possible routes, rapid trends, and new opportunities related to tactile devices in the foreseeable future.
Phoma Infections: Classification, Potential Food Sources, and Their Clinical Impact
Authors: Bennett Ashely , Ponder Michelle , Garcia-Diaz Julia
Published: June 2018

Phoma species are phytopathogens that are widely distributed in the environment, most commonly found in aquatic systems and soil. Phoma spp. have the potential to be pathogenic in plants, animals and humans; the latter is a rare occurrence. However, as our immunocompromised population increases, so do the reports of these infections. Medical advances have allowed for the increase in solid organ transplantation; chemotherapies to treat malignancies; and the use of other immunosuppressive agents, which have resulted in a greater population at risk when exposed to diverse fungi including Phoma spp. These fungi have been isolated from water sources, food, and crops; thus acting as opportunistic pathogens when the right host is exposed. Phoma spp. contaminates common food sources such as potatoes and maize, a common species isolated being Phoma sorghina. Though there is potential for causing infection via consumption of contaminated foods, there is insufficient data detailing what levels of organism can lead to an infection, and a regulated process for detecting the organism. The spectrum of disease is wide, depending on the host, ranging from cutaneous infections to invasive diseases. Mortality, however, remains low.
Effect of TiO2 on the Sintering Behavior of Chromium-Bearing Vanadium–Titanium Magnetite
Authors: Tang Weidong , Yang Songtao , Cheng Gongjin , Gao Zixian , Yang He , Xue Xiangxin
Published: June 2018

The sintering pot test was used to investigate the effect of TiO2 on the sintering behavior of chromium-bearing vanadium–titanium magnetite (CVTM) sinter. The main characterization methods of X-ray fluorescence (XRF), X-ray diffraction (XRD), scanning electron microscopy-energy disperse spectroscopy (SEM-EDS), and metallographic microscopy were employed. In this study, yield, tumbler index (TI), vertical sintering speed, productivity, reduction degradation index (RDI), and reduction index (RI) were tested and calculated. The yield first increases from 82.87% to 84.37% and then decreases to 83.65%, vertical sintering speed first increases from 17.00 mm·min−1 to 23.45 mm·min−1 and then decreases to 20.61 mm·min−1, and productivity first increases from 2.33 t·m−2·h−1 to 3.14 t·m−2·h−1 and then decreases to 2.69 t·m−2·h−1 with increasing TiO2 content. The TI increases from 45.81% to 52.09%, and RDI increases from 74.99% to 96.74%, while RI decreases from 67.92% to 47.15% with increasing TiO2 content.
Adsorption Mechanism of Pb2+ Activator for the Flotation of Rutile
Authors: Xiao Wei , Zhao Hongbo , Qin Wenqing , Qiu Guanzhou , Wang Jun
Published: June 2018

In general, the flotation of minerals containing titanium needs to be activated by metal ions due to a lack of activating sites on their surface. However, the activating process is indirectly inferred due to the lack of direct experimental observation. In this study, atomic force microscopy (AFM) was used to observe the activation process. The results revealed that the hydroxyl compounds of Pb2+ ions were adsorbed on the rutile surface in the form of multiple molecular associates, rather than through single molecule adsorption. Styryl phosphoric acid (SPA) could largely be adsorbed on the activated rutile surface with a single and double layer rather than on the un-activated rutile surface. The results of contact angle measurements also revealed that the hydrophobicity of the activated rutile surface was significantly greater than that of the un-activated rutile surface after SPA was adsorbed. This study will be helpful to understanding the activating process from the microscale.
Discovery of the Potential Biomarkers for Discrimination between Hedyotis diffusa and Hedyotis corymbosa by UPLC-QTOF/MS Metabolome Analysis
Authors: Wang Yaru , Wang Cuizhu , Lin Hongqiang , Liu Yunhe , Li Yameng , Zhao Yan , Li Pingya , Liu Jinping
Published: June 2018

Hedyotis diffuse Willd. (HD) and Hedyotis corymbosa (L.) Lam. (HC), two closely related species of the same genus, are both used for health benefits and disease prevention in China. HC is also indiscriminately sold as HD in the wholesale chain and food markets. This confusion has led to a growing concern about their identification and quality evaluation. In order to further understand the molecular diversification between them, we focus on the screening of chemical components and the analysis of non-targeted metabolites. In this study, UPLC-QTOF-MSE, UNIFI platform and multivariate statistical analyses were used to profile them. Firstly, a total of 113 compounds, including 80 shared chemical constituents of the two plants, were identified from HC and HD by using the UNIFI platform. Secondly, the differences between two herbs were highlighted with the comparative analysis. As a result, a total of 33 robust biomarkers enabling the differentiation were discovered by using multivariate statistical analyses. For HC, there were 18 potential biomarkers (either the contents were much greater than in HD or being detected only in HC) including three iridoids, eight flavonoids, two tannins, two ketones, one alcohol and two monoterpenes. For HD, there were15 potential biomarkers (either the contents were much greater than in HC or being detected only in HD) including two iridoids, eight flavonoids, one tannin, one ketone, and three anthraquinones. With a comprehensive consideration of the contents or the MS responses of the chemical composition, Hedycoryside A and B, detected only in HC, could be used for rapid identification of HC. The compounds 1,3-dihydroxy-2-methylanthraquinone and 2-hydroxy-3-methylanthraquinone, detected only in HD, could be used for rapid identification of that plant. The systematic comparison of similarities and differences between two confusing Chinese herbs will provide reliable characterization profiles to clarify the pharmacological fundamental substances. HC should not be used as the substitute of HD.
Nickel Sulfides Decorated SiC Foam for the Low Temperature Conversion of H2S into Elemental Sulfur
Authors: Duong-Viet Cuong , Nguyen-Dinh Lam , Liu Yuefeng , Tuci Giulia , Giambastiani Giuliano , Pham-Huu Cuong
Published: June 2018

The selective oxidation of H2S to elemental sulfur was carried out on a NiS2/SiCfoam catalyst under reaction temperatures between 40 and 80 °C using highly H2S enriched effluents (from 0.5 to 1 vol.%). The amphiphilic properties of SiC foam provide an ideal support for the anchoring and growth of a NiS2 active phase. The NiS2/SiC composite was employed for the desulfurization of highly H2S-rich effluents under discontinuous mode with almost complete H2S conversion (nearly 100% for 0.5 and 1 vol.% of H2S) and sulfur selectivity (from 99.6 to 96.0% at 40 and 80 °C, respectively), together with an unprecedented sulfur-storage capacity. Solid sulfur was produced in large aggregates at the outer catalyst surface and relatively high H2S conversion was maintained until sulfur deposits reached 140 wt.% of the starting catalyst weight. Notably, the spent NiS2/SiCfoam catalyst fully recovered its pristine performance (H2S conversion, selectivity and sulfur-storage capacity) upon regeneration at 320 °C under He, and thus, it is destined to become a benchmark desulfurization system for operating in discontinuous mode.
(+)-epi-Epoformin, a Phytotoxic Fungal Cyclohexenepoxide: Structure Activity Relationships
Authors: Cala Antonio , Masi Marco , Cimmino Alessio , Molinillo José M. G. , Macias Francisco A. , Evidente Antonio
Published: June 2018

(+)-epi-Epoformin (1), is a fungal cyclohexene epoxide isolated together with diplopimarane and sphaeropsidins A and C, a nor-ent-pimarane and two pimaranes, from the culture filtrates of Diplodia quercivora, a fungal pathogen for cork oak in Sardinia, Italy. Compound 1 possesses a plethora of biological activities, including antifungal, zootoxic and phytotoxic activity. The last activity and the peculiar structural feature of 1 suggested to carry out a structure activity relationship study, preparing eight key hemisynthetic derivatives and the phytotoxicity was assayed. The complete spectroscopic characterization and the activity in the etiolated wheat coleoptile bioassay of all the compounds is reported. Most of the compounds inhibited growth and some of them had comparable or higher activity than the natural product and the reference herbicide Logran. As regards the structure-activity relationship, the carbonyl proved to be essential for their activity of 1, as well as the conjugated double bond, while the epoxide could be altered with no significant loss.
Tetramethylpyrazine-Inducible Promoter Region from Rhodococcus jostii TMP1
Authors: Stanislauskienė Rūta , Kutanovas Simonas , Kalinienė Laura , Bratchikov Maksim , Meškys Rolandas
Published: June 2018

An inducible promoter region, PTTMP (tetramethylpyrazine [TTMP]), has been identified upstream of the tpdABC operon, which contains the genes required for the initial degradation of 2,3,5,6-tetramethylpyrazine in Rhodococcus jostii TMP1 bacteria. In this work, the promoter region was fused with the gene for the enhanced green fluorescent protein (EGFP) to investigate the activity of PTTMP by measuring the fluorescence of bacteria. The highest promoter activity was observed when bacteria were grown in a nutrient broth (NB) medium supplemented with 5 mM 2,3,5,6-tetramethylpyrazine for 48 h. Using a primer extension reaction, two transcriptional start sites for tpdA were identified, and the putative −35 and −10 promoter motifs were determined. The minimal promoter along with two 15 bp long direct repeats and two 7 bp inverted sequences were identified. Also, the influence of the promoter elements on the activity of PTTMP were determined using site-directed mutagenesis. Furthermore, PTTMP was shown to be induced by pyrazine derivatives containing methyl groups in the 2- and 5-positions of the heterocyclic ring, in the presence of the LuxR family transcriptional activator TpdR.
Documenting the Elusive and Ephemeral in Embodied Design Ideation Activities
Authors: Turmo Vidal Laia , Márquez Segura Elena
Published: June 2018

Documenting embodied ideation activities is challenging, as they often result in ephemeral design constructs and elusive design knowledge difficult to document and represent. Here, we explore documentation forms designers can use internally during the design process in the domain of movement-based interaction in collocated, social settings. Using previous work and our experience from embodied ideation workshops, we propose three documentation forms with complementing perspectives of embodied action from a first and a third person view. We discuss how they capture ephemeral embodied action and elusive design and experiential knowledge, in relation to two interdependent aspects of documentation forms: their performativity and the medium they use. The novelty of these forms lies in what is being captured: ephemeral design constructs that emerge as designers engage with the embodied ideation activity; how it is portrayed: in aggregation forms that highlight elusive design knowledge; and their purpose: to clarify and augment analytical results improving the designer-researchers’ understanding of key aspects of the embodied ideation process and its outcomes, useful to advance the design process and for research dissemination.
An Exploratory Study of the Uses of a Multisensory Map—With Visually Impaired Children
Authors: Brulé Emeline , Bailly Gilles , Brock Anke , Gentès Annie , Jouffrais Christophe
Published: June 2018

This paper reports an empirical study of a multisensory map used by visually impaired primary school pupils, to study human habitats and differences between urban, suburban and rural areas using a local example. Using multimodal analysis, we propose to examine how the use of smell and taste shape pupils’ engagement and the development of a non-visual knowledge of geography. Our research questions include: How do pupils try to make sense of this unusual material, in conjunction with the tactile, audio and tangible material used in this lesson? How does the special education teacher support the development of these interpretations? Multisensory material has the potential to support experiential and embodied learning: were these promises achieved? Our findings show how this multisensory map reconfigures spatial occupation and interaction dynamics, and that it has the potential to make the classroom more pervasive to pupils’ social, spatial and emotional lives. In doing so, it provides opportunities for the teacher to develop citizenship education. The paper provides concrete examples of uses of smell and taste in learning activities to support engagement, and has implications for pedagogical design beyond special education.
Interface Passivation Effects on the Photovoltaic Performance of Quantum Dot Sensitized Inverse Opal TiO2 Solar Cells
Authors: Hori Kanae , Zhang Yaohong , Tusamalee Pimsiri , Nakazawa Naoki , Yoshihara Yasuha , Wang Ruixiang , Toyoda Taro , Hayase Shuzi , Shen Qing
Published: June 2018

Quantum dot (QD)-sensitized solar cells (QDSSCs) are expected to achieve higher energy conversion efficiency than traditional single-junction silicon solar cells due to the unique properties of QDs. An inverse opal (IO)-TiO2 (IO-TiO2) electrode is useful for QDSSCs because of its three-dimensional (3D) periodic nanostructures and better electrolyte penetration compared to the normal nanoparticles (NPs)-TiO2 (NPs-TiO2) electrode. We find that the open-circuit voltages Voc of the QDSSCs with IO-TiO2 electrodes are higher than those of QDSSCs with NPs-TiO2 electrodes. One important strategy for enhancing photovoltaic conversion efficiency of QDSSCs with IO-TiO2 electrodes is surface passivation of photoanodes using wide-bandgap semiconducting materials. In this study, we have proposed surface passivation on IO-TiO2 with ZnS coating before QD deposition. The efficiency of QDSSCs with IO-TiO2 electrodes is largely improved (from 0.74% to 1.33%) because of the enhancements of Voc (from 0.65 V to 0.74 V) and fill factor (FF) (from 0.37 to 0.63). This result indicates that ZnS passivation can reduce the interfacial recombination at the IO-TiO2/QDs and IO-TiO2/electrolyte interfaces, for which two possible explanations can be considered. One is the decrease of recombination at IO-TiO2/electrolyte interfaces, and the other one is the reduction of the back-electron injection from the TiO2 electrode to QDs. All of the above results are effective for improving the photovoltaic properties of QDSSCs.
Nutrients, Nutraceuticals, and Xenobiotics Affecting Renal Health
Authors: Cosola Carmela , Sabatino Alice , Di Bari Ighli , Fiaccadori Enrico , Gesualdo Loreto
Published: June 2018

Chronic kidney disease (CKD) affects 8–16% of the population worldwide. In developed countries, the most important risk factors for CKD are diabetes, hypertension, and obesity, calling into question the importance of educating and acting on lifestyles and nutrition. A balanced diet and supplementation can indeed support the maintenance of a general health status, including preservation of renal function, and can help to manage and curb the main risk factors for renal damage. While the concept of protein and salt restriction in nephrology is historically acknowledged, the role of some nutrients in renal health and the importance of nutrition as a preventative measure for renal care are less known. In this narrative review, we provide an overview of the demonstrated and potential actions of some selected nutrients, nutraceuticals, and xenobiotics on renal health and function. The direct and indirect effects of fiber, protein, fatty acids, curcumin, steviol glycosides, green tea, coffee, nitrates, nitrites, and alcohol on kidney health are reviewed here. In view of functional and personalized nutrition, understanding the renal and systemic effects of dietary components is essential since many chronic conditions, including CKD, are related to systemic dysfunctions such as chronic low-grade inflammation.
Fat Loss in Continuous Enteral Feeding of the Preterm Infant: How Much, What and When Is It Lost?
Authors: Zozaya Carlos , García-Serrano Alba , Fontecha Javier , Redondo-Bravo Lidia , Sánchez-González Victoria , Montes María Teresa , Saenz de Pipaón Miguel
Published: June 2018

Human milk fat is a concentrated source of energy and provides essential and long chain polyunsaturated fatty acids. According to previous experiments, human milk fat is partially lost during continuous enteral nutrition. However, these experiments were done over relatively short infusion times, and a complete profile of the lost fatty acids was never measured. Whether this loss happens considering longer infusion times or if some fatty acids are lost more than others remain unknown. Pooled breast milk was infused through a feeding tube by a peristaltic pump over a period of 30 min and 4, 12 and 24 h at 2 mL/h. Adsorbed fat was extracted from the tubes, and the fatty acid composition was analyzed by gas chromatography-mass spectrometry. Total fat loss (average fatty acid loss) after 24 h was 0.6 ± 0.1%. Total fat loss after 24 h infusion was 0.6 ± 0.1% of the total fat infused, although the highest losses occur in the first 30 min of infusion (13.0 ± 1.6%). Short-medium chain (0.7%, p = 0.15), long chain (0.6%, p = 0.56), saturated (0.7%, p = 0.4), monounsaturated (0.5%, p = 0.15), polyunsaturated fatty (0.7%, p = 0.15), linoleic (0.7%, p = 0.25), and docosahexaenoic acids (0.6%, p = 0.56) were not selectively adsorbed to the tube. However, very long chain fatty (0.9%, p = 0.04), alpha-linolenic (1.6%, p = 0.02) and arachidonic acids (1%, p = 0.02) were selectively adsorbed and, therefore, lost in a greater proportion than other fatty acids. In all cases, the magnitude of the loss was clinically low.