bluuebunny/crossref_metadata_2025 huggingface dataset:
Serum Pharmacochemistry Combining Network Pharmacology to Discover the Active Constituents and Effect of Xijiao Dihuang Tang Prescription for Treatment of Blood-Heat and Blood-Stasis Syndrome-Related Disease
Authors: Chen Yuxin , Dai Yang , Xia Jie , Liu Jing , Zhou Guisheng , Chen Cuihua , Jiang Baoping , Yin Lian , Li Guochun
Published: February 2022

Xijiao Dihuang Tang (XDT), a classic TCM prescription, has been used to clinically treat blood-heat and blood-stasis syndrome- (BHSS-) related diseases, including hemorrhagic stroke and sepsis. However, the active constituents and mechanism of XDT in the treatment of BHSS-related diseases have not been elucidated due to the lack of appropriate methodologies. In this study, serum pharmacochemistry and network pharmacology were used to explore the active constituents and the mechanism of XDT in the treatment of BHSS-related diseases. The effects of XDT were evaluated using dry yeast-induced rats as rat models with BHSS, which demonstrated the antipyretic and anticoagulant properties of XDT. The HPLC-QTOF/MS/MS assay was used to identify 60 serum constituents of XDT (SCXDT). Then, 338 targets of 60 SCXDT were predicted by integrating multiple databases and the MACCS fingerprint similarity prediction method. The degree of topological properties with targets of 19 key active constituents in SCXDT was identified and evaluated in glutamate-induced PC12 cells. Subsequently, 338 targets of 60 SCXDT were mainly involved in biological processes such as inflammation, coagulation, cell proliferation, and apoptosis, as well as oxidative contingencies via compound-target-disease network analysis. The core targets including IL-1β, IL-6, TNF, NOS3, and MAPK1 were identified using protein-protein interaction network analysis, whereas dozens of signaling pathways such as the p38MAPK signaling pathway were identified using functional pathway enrichment analysis. The results indicated that XDT has broad therapeutic and neuroprotective effects on inflammation, coagulation, oxidative stress, cell proliferation, and apoptosis in dry yeast-induced rats with BHSS and glutamate-induced PC12 cells by regulating the p38MAPK signaling pathway. This study not only discovered the active constituents of XDT but also elaborated its mechanisms in the treatment of BHSS-related diseases by intervening in a series of targets, signaling pathways, and biological processes such as inflammation, coagulation, oxidative stress, neuroprotection. The findings in this study provide a novel strategy for exploring the therapeutic efficacy of TCM prescriptions.
Intelligent English Tense Collocation and Evaluation Based on Deep Reinforcement Learning
Authors: Ding Yiling , Wang Tianhua
Published: February 2022

The representation of time in sentences is the key problem for tense collocation. Based on the relationship expression among regions in Allen’s interval algebra theory, we propose a vector representation method, i.e., relationship vector, and several operations are defined based on the relationship vector for temporal reasoning in this work. This method transforms the original matrix representation into vector representation, which reduces the amount of computation of temporal reasoning. In addition, we propose a temporal classification and collocation method based on deep learning and deep reinforcement learning. This method uses a bidirectional cyclic neural network and a convolutional neural network for text expression and achieves temporal word classification and temporal collocation based on the deep reinforcement learning model. In the experiments, the proposed method obtains the average accuracy of 92.17% in five datasets, i.e., MPQA, CR, MR, Subj, and TREC, which proves its effectiveness in tense collocation.
Degree-Based Molecular Descriptors of Guar Gum and Its Chemical Derivatives
Authors: Shanmukha M. C. , Usha A. , Siddiqui M. K. , Fufa Samuel Asefa , Praveen B. M.
Published: February 2022

The most abundant polycarbonates that are found in food are polysaccharides. A long chain of monosaccharide with glycosidic linkages forms polymeric carbohydrates. These carbohydrates with water in the process of hydrolysis produces sugar monosaccharides or oligosaccharides. The examples of polysaccharides include starch, galactogen, and glycogen. They contribute various applications mainly in food storage, pharmaceutical industry, and petroleum extraction. In this work, a polysaccharide known as guar gum is studied and also ten degree-based topological indices, namely, Zagreb indices, Randic index, general Randic index, forgotten index, ABC index, GA index, GH index, Sombor index, and SS index are computed. The chemical derivatives of guar gum such as HPG, CMG, and CMHPG are studied, and topological indices are determined. Finally, numerical and graphical comparison of all the above said ten indices are made for guar gum and its chemical derivatives.
Study on Coupling Coordination Degree between Regional Sports Industry Development and Healthy China Construction
Authors: Tang Li
Published: February 2022

“Healthy China” is one of the most important goals in the development of China’s sports industry, which contributes to the realization of the macro development strategy of “Healthy China” and becomes the main trend of supply-side reform of sports industry. The realization of a healthy China can not be separated from the development of sports industry, and we can see that the future development of sports industry will have great prospects. The innovative development of sports industry economy not only shows the characteristics of the times, but also is a brand-new economic format from the perspective of public concern. The development of sports industry plays a fundamental role in the process of building a healthy China. By providing diversified and multi-level sports products and services, it can enhance the health value, enrich the healthy life and increase the healthy experience of consumers, thus promoting the building of a healthy China. This paper starts with the analysis of the opportunities of sports industry development under the healthy China strategy, and analyzes the implementation strategies of sports industry economic innovation and development under the healthy China strategy.
Clinical and Epidemiological Features of Patients with Drug-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Iran: Different Points of Children from Adults
Authors: Abtahi-Naeini Bahareh , Dehghan Mohammad-sadegh , Paknazar Fatemeh , Shahmoradi Zabihollah , Faghihi Gita , Sabzghabaee Ali Mohammad , Akbari Mojtaba , Hadian Mahdi , Momen Tooba
Published: February 2022

Background. Different epidemiologic aspects of drug-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in children are scarce. Aim. To compare the clinical and epidemiological features of patients with drug-induced SJS and TEN in children and adults. Method. This retrospective study was conducted at two academic referral centers (Isfahan, Iran) over 5 years. SJS and TEN were clinically diagnosed and confirmed by skin biopsy as needed. Results. One hundred one patients (31 children and 70 adults) with a female to male ratio of 1.1 : 1 was identified in the present study. SJS was more commonly diagnosed in both pediatric and adult patients. The most frequent reason for drug administration identified was the infection (45.2%) and seizure (45.2%) in children and infection (34.3%) and psychiatry disorder (27.1%) in adults (

P
=
0.001

). The most common culprit drugs in the pediatric were phenobarbital (9/31), cotrimoxazole (4/31), and amoxicillin (4/31); however, in the adult group, the most common drugs were carbamazepine (11/70) and lamotrigine (9/70). Fever was significantly more common in adults (44.3%) compared to pediatric patients (22.6%) (

P
=
0.03

). Multiple logistic regression models showed that pediatric patients had significantly lower odds of hospitalization (OR [odds ratio]: 0.14; 95% CI 0.02, 0.67). In addition, patients with SCORTEN 1 had significantly higher odds of hospitalization (OR: 6.3; 95% CI: 1.68, 23.79) compared to patients with SCORTEN 0. Conclusions. The present study showed several differences between the pediatric and adult patients with SJS and TEN, including the reason for drug administration, culprit drugs, length of hospital stay, presence of fever, and final diagnosis of disease.
Hyers‐Ulam‐Rassias‐Wright Stability for Fractional Oscillation Equation
Authors: Eidinejad Zahra , Saadati Reza
Published: February 2022

In this paper, we consider the nonhomogeneous fractional delay oscillation equation with order σ and introduce a class of control functions, i.e., Wright functions. Next, we apply the Cădariu‐Radu method to prove the existence of a unique solution and Hyers‐Ulam‐Rassias‐Wright stability of the fractional delay oscillation equation. At the end of the article, by an example, we show the application of the obtained results.
Maximal Soft Compact and Maximal Soft Connected Topologies
Authors: Al Ghour Samer , Ameen Zanyar A.
Published: February 2022

In various articles, it is said that the class of all soft topologies on a common universe forms a complete lattice, but in this paper, we prove that it is a complete lattice. Some soft topologies are maximal, and some are minimal with respect to specific soft topological properties. We study the properties of soft compact and soft connected topologies that are maximal. Particularly, we prove that a maximal soft compact topology has identical families of soft compact and soft closed sets. We further show that a maximal soft compact topology is soft

T

1

, while a maximal soft connected topology is soft

T

0

. Lastly, we establish that each soft connected relative topology to a maximal soft connected topology is maximal.
Prolongation of Neoadjuvant Chemotherapy before Surgery: Seeking the Optimal Number of Cycles in Serous Ovarian Cancer
Authors: Minareci Yagmur , Sozen Hamdullah , Ak Naziye , Tosun Ozgur A. , Saip Pınar , Salihoglu M. Yavuz , Topuz Samet
Published: February 2022

Aim: The optimal number of neoadjuvant chemotherapy (NACT) cycles is unclear in epithelial ovarian cancer. Our study aimed to evaluate the effect of the number of NACT cycles before interval debulking surgery on survival. Methods: Data of 221 patients with advanced-stage serous epithelial ovarian cancer (EOC) were retrospectively evaluated. The patients were divided into groups as who received 3 cycles of NACT (group A), 4-5 cycles of NACT (group B), and 6 cycles of NACT (group C). Results: There were 67 (30%) patients in group A, 70 (32%) in group B, and 84 (38%) in group C. Median overall survival (OS) was 61 (range 43–79) months for group A, 44 (range 36–52) months for group B, and 39 (range 27–50) months for group C. In addition, median disease-free survival (DFS) was 23.1 (range 8.5–32.1) months for group A, 19.2 (range 10.1–28.4) months for group B, and 21.5 (range 16–27) months for group C. Patients receiving >3 NACT cycles had worse OS than patients who received 3 NACT cycles (for group A vs. B, p = 0.018; for group A vs. C, p = 0.049). However, in terms of DFS, patients receiving 3 NACT cycles had no statistically significant difference compared to patients who received >3 NACT cycles. Conclusions: Patients with advanced-stage serous EOC who received more than 3 cycles of NACT had poor OS. However, there was no statistical difference in terms of DFS. In addition, >3 cycles of NACT did not increase the probability of achieving complete cytoreduction at the time of surgery.
Fludrocortisone Is an Effective Treatment for Hyperkalaemic Metabolic Acidosis in Kidney Transplant Recipients on Tacrolimus: A Case Series
Authors: Gama Rouvick M. , Makanjuola David , Wahba Mona , Quan Virginia , Phanish Mysore
Published: February 2022

Background: Hyperkalaemia with metabolic acidosis is common but under-reported following kidney transplantation. Calcineurin inhibitors, such as tacrolimus, are widely used in the management of transplant patients and are associated with the development of hyperkalaemia. We report on 10 renal transplant patients, treated with fludrocortisone, following identification of hyperkalaemic metabolic acidosis. Results: All 10 patients were male aged (mean ± SD) 53.0 ± 13.2 years; 7 were Caucasian and 3 South Asian. Before and after fludrocortisone administration, respective (mean ± SD) serum potassium was 6.1 ± 0.4 mmol/L and 5.3 ± 0.3 mmol/L (p = 0.0002); serum bicarbonate 18.5 ± 1.6 mmol/L and 20.5 ± 2.3 mmol/L (p = 0.002); serum sodium 135 ± 4.6 mmol/L and 137 ± 2.2 mmol/L (p = 0.0728); serum creatinine 181 ± 61 μmol/L and 168 ± 64 μmol/L (p = 0.1318); eGFR 42 ± 18 mL/min and 46 ± 18 mL/min (p = 0.0303); blood tacrolimus 10.1 ± 2.9 ng/mL and 10.4 ± 1.4 ng/mL (p = 0.7975); and blood pressure 129 ± 15/79 ± 25 mm Hg and 126 ± 24/75 ± 7 mm Hg. Pre-fludrocortisone, there were 7 episodes of serum potassium ≥6.5 mEq/L, with 4 patients requiring admission for the treatment of hyperkalaemia. Following fludrocortisone, no patients had hyperkalaemia requiring inpatient management. Conclusions: Treatment of hyperkalaemic metabolic acidosis in transplant patients on tacrolimus with low-dose fludrocortisone resulted in rapid correction of hyperkalaemia and acidosis without significant effects on blood pressure or serum sodium. Fludrocortisone can be an effective short-term option for the treatment of hyperkalaemic metabolic acidosis in kidney transplant recipients on tacrolimus; however, patient selection remains important in order to reduce to risk of potential adverse effects.
Oral Wheat Immunotherapy: Long-Term Follow-Up in Children with Wheat Anaphylaxis
Authors: Babaie Delara , Ebisawa Motohiro , Soheili Habib , Ghasemi Ramin , Zandieh Fariborz , Sahragard Mitra , Seifi Hamideh , Fallahi Mazdak , Khoshmirsafa Majid , Darougar Sepideh , Mesdaghi Mehrnaz
Published: February 2022

Introduction: There has been substantial increase in food allergies in recent decades. The management of severe food allergy often includes strict avoidance and medical therapies. However, oral immunotherapy (OIT) is a promising treatment option for these patients, which is still being investigated. Methods: The study recruited children from 2 years onward with a history of wheat anaphylaxis who had been referred to the Mofid Children Hospital. Wheat allergy was confirmed by a double-blind placebo-controlled food challenge. OIT was started to reach 5.28 g of wheat protein supplied in 60 g of bread. Besides immunologic measurements, a second and third oral food challenge (OFC) was performed after 3 months and 1 year of maintenance therapy to evaluate the long-term efficacy of wheat OIT (WOIT). Results: Seventeen patients completed the 3-month maintenance phase; 8 of them demonstrated negative OFCs. All of the 9 with positive OFCs were asked to continue the daily consumption of 60 g of bread for another year. Three patients with positive OFCs were followed for 1 more year and were asked to continue eating 60 g of bread every other day. The serum level of wheat sIgE was significantly increased at the end of the buildup phase (p = 0.026) and dramatically dropped at the end of the maintenance phase (p = 0.022). Conclusion: To conclude, WOIT is an effective and safe modality of treatment if it is administered under strict supervision.
Use of Wireless Ultrasound Probe in Isolated Infants: A Case Report of Two SARS-CoV-2-Positive Mothers’ Newborns
Authors: Prontera Giorgia , Perri Alessandro , Vento Giovanni , D’Andrea Vito
Published: February 2022

The COVID-19 pandemic has upset habits in any workplace. In hospitals, several precautions have been taken to maintain health-care workers’ safety and to avoid disease spread or the possible creation of new epidemic outbreaks. The use of medical devices makes the contamination and the nosocomial virus spread possible, causing infection in medical operators and hospitalized patients. In the neonatal intensive care unit, ultrasound has been an increasingly used tool because it is a non-invasive, repeatable method and it is side effect-free as the newborn is not exposed to radiation. It makes a fast diagnosis and then therapy possible such as in the lung diseases and other life-threatening conditions. The use of portable devices such as the wireless probe has many advantages in routine clinical practice, and during the COVID-19 pandemic, it has proved to be fundamental for the patient and the physician’s safety because it reduced the risk of contamination. We report the use of the wireless ultrasound probe in 2 isolated neonates born to SARS-CoV-2-positive mothers.
Cognitive Predictors of Delirium on Long-Term Follow-Up after TIA and Stroke: Population-Based Cohort Study
Authors: Pendlebury Sarah T. , Thomson Ross J. , Welch Sarah J.V. , Rothwell Peter M. ,   Oxford Vascular Study
Published: February 2022

Introduction: TIA and stroke cause cognitive impairment with a typical “vascular” pattern, including prominent frontal/executive deficits. Cognitive impairment is associated with increased delirium risk and the few available data suggest that executive dysfunction is important. We therefore determined the predictive value of both severity and pattern of cognitive deficits for delirium on long-term follow-up after TIA/stroke. Methods: Surviving TIA/stroke participants on October 1, 2013, in the Oxford Vascular Study (OXVASC) were assessed prospectively for delirium during all hospitalizations over the subsequent 6 months. Associations between OXVASC pre-admission mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores, and delirium during hospitalizations on follow-up were determined using logistic regression adjusted for covariates, including demographic factors, history of depression, baseline stroke severity, and admission illness severity. Results: Among 1,565 TIA/stroke survivors, 158 patients (mean/SD age = 79.2/11.5 years) had ≥1 admission and 59 (37%) had ≥1 delirium episode. Mean/SD time between baseline TIA/stroke and admission was 4.7/3.6 years and between most recent OXVASC cognitive testing and admission was 1.7/1.8 years. MMSE and MoCA scores were associated with delirium: odds ratio (OR) = 1.16 (95% CI 1.07–1.27, p < 0.0001 per point decrease in MMSE) and OR = 1.20 (1.11–1.30, p < 0.0001 MoCA) and associations were robust to adjustment for all covariates, including stroke severity: OR = 1.11 (1.01–1.22, p = 0.03, MMSE) and OR = 1.15 (1.05–1.25, p = 0.003, MoCA). All 10 subtests on the MoCA and 4/11 on the MMSE were significantly associated with delirium with highest predictive value for frontal/executive and recall domains. Conclusions: Cognitive impairment of increasing severity after TIA/stroke predisposed to delirium particularly deficits in frontal/executive domains and recall. Long-term risk of delirium should be considered as part of the overall cerebrovascular disease burden.
Dysregulated MDR1 by PRDM1/Blimp1 Is Involved in the Doxorubicin Resistance of Non-Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma
Authors: Qing Kai , Jin Zhen , Xu Zizhen , Wang Wenfang , Li Xiaoyang , Zhang Yunxiang , Wang Lining , Zhu Hongming , Xiang Rufang , Wu Shishuang , Li Ran , Jiang Ge , Xue Kai , Li Junmin
Published: February 2022

Introduction: The chemoresistance mechanism of diffuse large B-cell lymphoma (DLBCL) is still poorly understood, and patient prognosis remains unsatisfactory. This study aimed to investigate drug resistance mechanisms in non-germinal center B-cell-like (non-GCB) DLBCL. Methods: Doxorubicin (DOX)-resistant OCI-Ly3 cells were generated through long-term incubation of cells in a medium with gradually increasing DOX concentrations. The expression levels of genes related to drug metabolism were determined using a functional gene grouping polymerase chain reaction (PCR) array. Drug-resistant proteins were identified using bioinformatics, and molecular association networks were subsequently generated. The association and mechanism of key genes were determined using a dual-luciferase reporter assay System and chromatin immunoprecipitation (ChIP). The expression of drug-resistant genes and target genes was then measured using Western blotting and immunohistochemistry. The correlation between gene expressions was analyzed using Spearman’s rank correlation coefficient. Results: Using the PCR array, MDR1 was identified as the key gene that regulates DOX resistance in OCI-Ly3/DOX-A100, a non-GCB DLBCL cell line. The dual-luciferase reporter assay system demonstrated that MDR1 transcription could be inhibited by PRDM1. ChIP results showed that PRDM1 had the ability to bind to the promoter region (−1,132 to −996) of MDR1. In OCI-Ly3/DOX cells, NF-κB activity and PRDM1 expression decreased with an increase in drug-resistant index, whereas MDR1 expression increased with enhanced drug resistance. Immunohistochemical analysis revealed that relative MDR1 expression was higher than that of PRDM1 in human DLBCL tissue samples. A negative correlation was observed between MDR1 and PRDM1. Conclusion: In non-GCB DLBCL cells, NF-κB downregulates PRDM1 and thereby promotes MDR1 transcription by terminating PRDM1-induced transcriptional inhibition of MDR1. Such a mechanism may explain the reason for disease recurrence in non-GCB DLBCL after R-CHOP or combined CHOP with bortezomib treatment. Our findings may provide a potential therapeutic strategy for reducing drug resistance in patients with DLBCL.
Papillary Thyroid Carcinoma with Honeycomb-Like Growth: Clinicopathological Characteristics and Diagnostic Significance as a Novel Variant
Authors: Hirokawa Mitsuyoshi , Higuchi Miyoko , Suzuki Ayana , Hayashi Toshitetsu , Kuma Seiji , Miyauchi Akira
Published: February 2022

Introduction: We aimed to clarify the clinical and pathological characteristics of papillary thyroid carcinoma (PTC) with unique honeycomb-like growth (HLG) and discuss its diagnostic significance. Methods: Among the 12,745 PTCs that were resected and histologically diagnosed, 28 PTC cases with HLG components (0.2%) were included. Results: PTC-HLG was subclassified into pure (9 cases), which consisted of only HLG components, and mixed (19 cases), which consisted of conventional PTC and HLG components, types. HLG components were histologically characterized by (1) neoplastic cyst aggregation with intervening normal thyroid follicles, (2) the cyst wall composed of single-layered carcinoma cells, (3) low papillary growth, and (4) ball-like granulation tissues. Compared with the mixed type, the pure type occurred in older people (p < 0.05), had a smaller tumor size (p < 0.0001), was more interpreted as being benign by ultrasound (p < 0.05), and had a lower lymph node metastasis rate (p < 0.005). In the mixed type, 44.4% of conventional PTCs showed a Ki-67 labeling index of >5%. All and 10.5% of the mixed type showed lymph node and lung metastases, respectively. Conclusion: The pure type could be a nonaggressive variant of PTCs with a unique honeycomb growth pattern and tended to be clinically interpreted as benign. The mixed type is pathogenetically different from the pure type and is slightly aggressive compared with conventional PTCs.
Brodalumab Is Associated with High Rates of Complete Clearance and Quality of Life Improvement: A Subgroup Analysis of Patients with Psoriasis and Concomitant Psoriatic Arthritis
Authors: Kokolakis Georgios , Vadstrup Kasper , Hansen Jes B. , Carrascosa Jose Manuel
Published: February 2022

Background: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis that significantly impairs physical function and quality of life (QoL). Prompt therapeutic intervention is crucial for limiting PsA progression and preventing disability. Objectives: The aim of this study was to compare the efficacy of brodalumab versus ustekin­umab and the impact on QoL in patients with moderate-to-severe plaque psoriasis, by concomitant PsA status. Methods: This post hoc analysis of pooled data from the phase 3 AMAGINE-2 and -3 trials evaluated complete skin clearance (100% improvement of Psoriasis Area and Severity Index [PASI 100]), improvement in symptom severity (Psoriasis Symptom Inventory [PSI] response), and QoL (Dermatology Life Quality Index [DLQI] score of 0/1) by concomitant PsA status. A competing risk model assessed cumulative incidence over 52 weeks with outcomes of PASI 100 or inadequate response. Results: This analysis included 929 patients with moderate-to-severe psoriasis. Concomitant PsA was present in 79/339 (23%) and 110/590 (19%) patients receiving brodalumab 210 mg and ustekinumab, respectively. At Week 52, odds ratios (ORs) (95% confidence intervals [CIs]) for complete clearance with brodalumab versus ustekin­umab were 3.15 (1.52–6.55, p = 0.0015) in patients with concomitant PsA and 3.05 (2.19–4.26, p < 0.0001) in patients without concomitant PsA. Corresponding Week 52 ORs (95% CIs) for DLQI 0/1 with brodalumab versus ustekinumab were 2.05 (1.07–3.90, p = 0.0277) and 1.83 (1.32–2.53, p = 0.0002); Week 52 ORs (95% CIs) for PSI ≤8 with brodalumab versus ustekinumab were 3.42 (1.43–8.18, p = 0.0036) and 1.40 (1.01–1.95, p = 0.0434). The 52-week cumulative incidence of patients achieving PASI 100 was significantly higher for brodalumab versus ustekinumab in patients with concomitant PsA (p = 0.0001) and in those without concomitant PsA (p < 0.0001). Conclusions: Treatment with brodalumab rapidly results in high levels of complete and sustained skin clearance and greater cumulative treatment benefit in patients with moderate-to-severe psoriasis versus ustekinumab, regardless of concomitant PsA status.
A Case with NAD(P)HX Dehydratase (NAXD) Deficiency: A Newly Defined Mutation in a Novel Neurodegenerative Disorder
Authors: Oz Tuncer Gökçen , Randa Nadide Cemre , Aydin Seren , Aksoy Ayşe
Published: February 2022

Introduction: Nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) are required redox equivalents for essential biochemical reactions. Their hydrated forms, NADHX and NAD(P)HX, are inhibitors for several dehydrogenases and cause harmful byproducts. NAD(P)HX dehydratase (NAXD) and NAD(P)HX epimerase (NAXE) together form the nicotinamide repair system. Case Presentation: A 7-month-old boy was admitted due to myoclonic seizures, impaired consciousness, and rapid loss of head control. One of his siblings regressed after a febrile seizure and died at 7 months. He had lethargy and axial hypotonia but skin lesions and organomegaly were not noted. Basal metabolic tests were within normal limits except serum and cerebrospinal fluid lactate levels, which were mildly elevated. Mitochondrial cocktail was added to the antiepileptic treatment with suspicion of mitochondrial disease. Whole-exome sequencing showed a novel homozygous mutation (c.247G>A) in the NAXD gene. His seizures stopped within a few weeks. However, he died at the age of 18 months. Discussion: Prominent features of NAXD deficiency are progressive neurological deterioration after fever, cardiomyopathy, skin lesions, and premature death. Unlike the cases reported in the literature, our patient had neither preceding fever nor skin lesion during follow-up. It appears that cases show phenotypic diversity.
Systemic Therapy for Hepatocellular Carcinoma: Chinese Consensus-Based Interdisciplinary Expert Statements
Authors: Sun Yongkun , Zhang Wen , Bi Xinyu , Yang Zhengqiang , Tang Yu , Jiang Liming , Bi Feng , Chen Minshan , Cheng Shuqun , Chi Yihebali , Han Yue , Huang Jing , Huang Zhen , Ji Yuan , Jia Liqun , Jiang Zhichao , Jin Jing , Jin Zhengyu , Li Xiao , Li Zhiyu , Liang Jun , Liu Lianxin , Liu Yunpeng , Lu Yinying , Lu Shichun , Meng Qinghua , Niu Zuoxing , Pan Hongming , Qin Shukui , Qu Wang , Shao Guoliang , Shen Feng , Song Tianqiang , Song Yan , Tao Kaishan , Tian Aiping , Wang Jianhua , Wang Wenling , Wang Zhe , Wu Liqun , Xia Feng , Xing Baocai , Xu Jianming , Xue Huadan , Yan Dong , Yang Lin , Ying Jianming , Yun Jingping , Zeng Zhaochong , Zhang Xuewen , Zhang Yanqiao , Zhang Yefan , Zhao Jianjun , Zhou Jianguo , Zhu Xu , Zou Yinghua , Dong Jiahong , Fan Jia , Lau Wan Yee , Sun Yan , Yu Jinming , Zhao Hong , Zhou Aiping , Cai Jianqiang
Published: February 2022

Background: Hepatocellular carcinoma (HCC) is the most common type of liver cancer and causes many cancer-related deaths worldwide; in China, it is the second most prevalent cause of cancer deaths. Most patients are diagnosed clinically with advanced stage disease. Summary: For more than a decade, sorafenib, a small-molecular-weight tyrosine kinase inhibitor (SMW-TKI) was the only molecular targeted drug available with a survival benefit for the treatment of advanced HCC. With the development of novel TKIs and immune checkpoint inhibitors for advanced HCC, the management of patients has been greatly improved. However, though angiogenic-based targeted therapy remains the backbone for the systemic treatment of HCC, to date, no Chinese guidelines for novel molecular targeted therapies to treat advanced HCC have been established. Our interdisciplinary panel on the treatment of advanced HCC comprising hepatologists, hepatobiliary surgeons, oncologists, radiologists, pathologists, orthopedic surgeons, traditional Chinese medicine physicians, and interventional radiologists has reviewed the literature in order to develop updated treatment regimens. Key Messages: Panel consensus statements for the appropriate use of new molecular -targeted drugs including doses, combination therapies, adverse reaction management as well as efficacy evaluation, and predictions for treatment of advanced HCC with evidence levels based on published data are presented, thereby providing an overview of molecular targeted therapies for healthcare professionals.
BNT162b2 mRNA COVID-19 (Comirnaty) Vaccine Effectiveness in Elderly Patients Who Live in Long-Term Care Facilities: A Nationwide Cohort
Authors: Goldin Sivan , Adler Limor , Azuri Joseph , Mendel Liran , Haviv Shay , Maimon Nimrod
Published: February 2022

Introduction: In early 2020, the novel SARS-CoV-2 virus began to spread around the world and claim victims. Initially, in the Western world, COVID-19-related mortality was due to illness in long-term care facilities (LTCFs). To manage the COVID-19 crisis in LTCFs in Israel, the Ministry of Health established a task force named “Senior Shield.” The task force executed a screening program of weekly polymerase chain reaction (PCR) SARS-CoV-2 tests for LTCF residents and caregivers, and at a later stage, the task force led the Ministry of Health vaccination program at LTCFs. This study aimed to estimate the effectiveness of the BNT162b2 mRNA COVID-19 (Comirnaty) vaccine in reducing COVID-19 morbidity and mortality in LTCF residents. Methods: We designed a nationwide cohort study utilizing data from the Senior Shield task force. Residents had received the vaccines starting December 2020. The study follow-up period was 5 months (ending May 2021). We defined four outcomes: (a) documented SARS-CoV-2 infection, defined by a positive PCR test, (b) COVID-19 death, defined by a positive PCR test followed by death, (c) all-cause mortality, defined as death regardless of the result of a PCR test, and (d) a composite endpoint which included documented SARS-CoV-2 infection or death, the earliest of both. We used Kaplan-Meier curves with a log-rank comparison and Cox regression with a time-dependent covariate model to estimate adjusted hazard ratios for vaccine effectiveness (VE). The index date was the date of the first vaccine dose. In unvaccinated residents, the index date was the first date of vaccination in their LTCF. Results: A total of 43,596 residents with a mean age of 83 years living in 454 LTCFs were found eligible for this study. Ninety-one percent of the study population received the first vaccine dose (39,482) and 86% received the second vaccine dose (37,656). Estimated VE 28 days after the first vaccine dose (approximately 7 days after the second vaccine dose) was 81.2% for SARS-CoV-2 infection, 85.3% for COVID-related death, 63.7% for all-cause mortality, and 71.1% for the composite endpoint (SARS-CoV-2 infection or death). Conclusion: This study shows that the BNT162b2 mRNA COVID-19 vaccine effectively prevents SARS-CoV-2 infection, COVID-19-related death, and all-cause mortality in LTCF residents. Further research is warranted on the effect of the third vaccine (booster) in this population.
Metformin-Induced Heat Shock Protein Family A Member 6 Is a Promising Biomarker of Esophageal Squamous Cell Carcinoma
Authors: Sekino Nobufumi , Kano Masayuki , Kobayashi Sohei , Murakami Kentaro , Sakata Haruhito , Toyozumi Takeshi , Endo Satoshi , Matsumoto Yasunori , Suito Hiroshi , Takahashi Masahiko , Otsuka Ryota , Yokoyama Masaya , Shiraishi Tadashi , Okada Koichiro , Kamata Toshiki , Ryuzaki Takahiro , Hirasawa Soichiro , Kinoshita Kazuya , Sasaki Takuma , Iida Keiko , Komatsu Aki , Matsubara Hisahiro
Published: February 2022

Introduction: Antidiabetic drug metformin exerts various antitumor effects on different cancers. Esophageal squamous cell carcinoma (ESCC) is an intractable digestive organ cancer and new treatment strategy is required. In this study, we performed a comprehensive gene expression analysis of ESCC cell lines treated with metformin, which provided helpful information on the antitumor effects of metformin in ESCC. Next, we selected a promising gene among them and examined its effects on ESCC properties. Methods: We examined metformin-induced mRNA expression changes in two human ESCC cell lines by performing next-generation sequencing (NGS) and pathway analysis. Heat shock protein family A (Hsp70) member 6 (HSPA6) expression in surgical specimens obtained from 83 ESCC patients who underwent curative operations was evaluated immunohistochemically and analyzed. Results: Metformin upregulated mRNA expression of the many genes, including HSPA6, a cancer immune-related gene, and inhibited mRNA expression of the other many genes. Pathway analysis indicated major canonical pathways and upstream regulators related to metformin. The result indicated HSPA6 as a promising biomarker. HSPA6 expression correlated with disease-free survival (DFS) of the patients with all stage ESCC (p = 0.021), especially with stage I/II ESCC (p < 0.001). With stage III, low HSPA6 expression was not associated with poor DFS (p = 0.918). Multivariate analysis indicated that independent low HSPA6 expression was an independent poor prognostic factor of stage I/II ESCC (p < 0.001). However, HSPA6 expression did not correlate with the clinicopathological characteristics, including age, sex, tumor depth, lymph node metastasis, tumor stage, and tumor markers of the patients with stage I/II ESCC. Conclusions: This NGS analysis detected prospective candidate genes, including HSPA6. Our results indicate that HSPA6 is a promising biomarker of the recurrence risk of stage I/II ESCC. Further studies on HSPA6 would lead to better treatment.
Intelectuais: Porta-vozes dos pobres?
Authors: Martin Lenhard
Published: February 2022

Intelectuais: Porta-vozes dos pobres?
Tinta vermelha ou tinta azul? Resenha do livro Harvey, David; Maricato, Ermínia; Zizek, Slavoj Et. Al (2013). Cidades rebeldes. São Paulo: Boitempo Editorial.
Authors: Dunker Christian Lenz
Published: February 2022

Tinta vermelha ou tinta azul? Resenha do livro Harvey, David; Maricato, Ermínia; Zizek, Slavoj Et. Al (2013). Cidades rebeldes. São Paulo: Boitempo Editorial.
Cultura dos povos tradicionais de terreiros: percurso de vivências na Universidade Federal do Rio de Janeiro
Authors: Moreira Aderbal Ashogun , Mantuano Clarisse , Peres Marta Simões
Published: February 2022

O texto relata uma experiência de colaboração entre Aderbal Ashogun Moreira, mestre da cultura tradicional de matriz africana (Candomblé), o Departamento de Arte Corporal (Dança) da Escola de Educação Física e Desportos da Universidade Federal do Rio de Janeiro, em novembro de 2012. O mestre ensinou canto, dança, toque, mitologia, línguas, medicina, fitoterapia, cromoterapia, comida sagrada, arte sacra e práticas tradicionais sustentáveis. O principal objetivo foi diminuir a distância entre saberes tradicionais e convencionais, valorizando e difundindo a cultura afro-brasileira como fonte de um conhecimento ainda hoje invisibilizado por séculos de opressão pelos colonizadores europeus. Por conta desta confluência de saberes e práticas, estabelecemos um diálogo o conceito de “Polifonia”, de Bakhtin e a Pedagogia Griô (Pacheco/Caires).
Repensando Carolina Maria de Jesus
Authors: Meihy José Carlos Sebe Bom
Published: February 2022

Repensando Carolina Maria de Jesus
A inclusão do silenciamento Resenha do livro Marilucia Melo Meireles. Os “bobos” de Goiás: enigm as e silêncios. Goiânia, Editora UFG, 2014, 368 páginas. ISBN : 978-85-7274- 374-7
Authors: Cunha Arantes Maria Auxiliadora de Almeida
Published: February 2022

A inclusão do silenciamento. Resenha do livro Marilucia Melo Meireles. Os “bobos” de Goiás: enigm as e silêncios. Goiânia, Editora UFG, 2014, 368 páginas. ISBN : 978-85-7274-374-7
Todo instrumento é um instrumento (mágico) de poder. Resenha da obra de Thiago Honório. Documents (2012)
Authors: Galvão Edimar
Published: February 2022

Todo instrumento é um instrumento (mágico) de poder. Resenha da obra de Thiago Honório. Documents (2012)
Os direitos humanos, a educação como um direito humano e as lutas contemporâneas: perspectivas
Authors: Schilling Flávia
Published: February 2022

Os direitos humanos, a educação como um direito humano e as lutas contemporâneas: perspectivas
“Rango é rango”: o animal subtraído no dispositivo cardápio
Authors: Costa Luanda Francine G. da , Castro Odilon
Published: February 2022

E ste artigo visa desnaturalizar a alimentação baseada em animais por meio do conceito de dispositivo elaborado por Michel Foucault e desenvolvido por Giorgio Agamben, apresentando o cardápio como uma tecnologia de poder que fixa os animais em seu centro enquanto referenciais ausentes, gerenciando suas vidas e produzindo “o gostar” dos sujeitos. Por intermédio de análises de discursos produzidos pelo dispositivo cardápio, evidenciamos a questão da captura ideológica e do apagamento dos animais. Por fim, indicamos a necessidade da realização de uma análise crítica do sujeito frente ao dispositivo e sua responsabilização pela efetivação deste
Retórica e Memória em algumas estrofes d'Os Lusíadas
Authors: Burlamaqui Neto Lourival da Silva
Published: February 2022

Nas sociedades de corte, o poema épico possuía íntima conexão com o discurso historiográfico. Nesses contextos, o enredo da ficção épica era construído sobre um notável feito da história nacional, cabendo ao escritor reconfigurar esse evento na trama poemática (dispositio) e orná-lo com diversos recursos retóricos (elocutio). Dessa forma, a memória dos feitos nacionais e de outras ações louváveis do passado, à medida que constituía uma espécie de arquivo ao qual o autor recorria com o intuito de encontrar a matéria ideal para seu canto, também servia de parâmetro ao leitor que, averiguando as modificações e acréscimos impostos ao episódio histórico, avaliava a capacidade inventiva do poeta. Os Lusíadas, poema épico de Luís de Camões, insere-se nessa dinâmica e apresenta um notável aproveitamento das crônicas portuguesas medievais e dos relatos de viagem lusitanos, constituindo-se no panteão em que estavam presentes tipos históricos ilustres. O autor português, porém, considerando os preceitos de uma poética estruturada sobre Aristóteles (1984), Horácio (1984) e Quintiliano (2015, 2016) imprimiu variações nas suas fontes, articulando a memória dos feitos nacionais com um tratamento retórico engenhoso. Este artigo analisa algumas estrofes presentes nos cantos III e V de Os Lusíadas à luz do conceito memória e do teor retórico dessas passagens. Emprega-se a primeira definição para demonstrar que várias passagens do poema acumulam referências a textos de épocas diversas, aglutinando, em poucos versos, tempos muito distintos. Demonstra-se, assim, que a memória, além de ser um arcabouço de referências simbólicas, é o fio, a faculdade criadora que viabiliza esse amálgama temporal de imagens anacrônicas. Esse caleidoscópio temporal, como demonstram Alves (2011), Ford (2007) e Hansen (2008), possuía correspondência com a própria estrutura da epopeia, caracterizada pela heterogeneidade de gêneros retóricos. Por fim, trata-se brevemente, através do episódio do Adamastor, do esquecimento no panorama renascentista.
Vítimas fatais do salazarismo: realidade e ficção em "Balada da praia dos cães: dissertação sobre um crime" (1982), de José Cardoso Pires
Authors: Rocha Denise
Published: February 2022

O objetivo do estudo é apresentar as variadas facetas da realidade e da ficção do crime do Guincho (1960) - o assassinato do capitão Almeida Santos, um dos líderes do Golpe da Sé (1959) para derrubar a ditadura de Salazar - que abalou a opinião pública portuguesa e motivou a escrita da Balada da Praia dos Cães (1982), de José Cardoso Pires. A narrativa polifônica (Bakhtin), que será analisada segundo reflexões de Hutcheon e Todorov, evoca o ambiente de medo e violência em Lisboa, e revela a ruptura de paradigmas consagrados do romance, ao mesclar variados registros: dossiês policiais, autos e relatórios com jargões e técnicas de inquérito e de medicina legal forenses; textos e intertextos: notas de rodapé explicativas sobre a biografia de personagens e eventos históricos, notícias de jornais, panfletos etc.

Palavras-chave: Literatura portuguesa; José Cardoso Pires; Balada da Praia dos Cães; história; ficção.
Conexão Angola-Portugal: os dias de ponte aérea de um povo retornado
Authors: Pacheco Pietro Gabriel dos Santos
Published: February 2022

O fim da ditadura militar portuguesa através da Revolução dos Cravos anuncia o início de um novo período que se reflete não apenas em Portugal, mas sim em suas colônias, sobretudo em Angola e Moçambique, que passam a projetar seus processos de independência e construção de uma nação feita por e para africanos. Como resultado, cerca de meio milhão de portugueses são obrigados a abandonar suas casas em África e regressar para a Metrópole. Este trabalho tem por objetivo narrar sobre essas viagens retratadas na obra S.O.S Angola, da jornalista Rita Garcia. Como teóricos, utiliza-se uma introdução literária, do professor Carlos Reis e os conceitos de geometria da memória, dos pesquisadores António Souza Ribeiro e Margarida Calafate Ribeiro e de Diáspora, com Stuart Hall.
Nietzsche e Pascoaes, ou o silêncio como acontecimento
Authors: Araujo Rodrigo Michell
Published: February 2022

Este artigo visa analisar a presença de Nietzsche na obra poética de Teixeira de Pascoaes. Em vários momentos de sua criação literária o poeta do Marão estreitou laços com o filósofo alemão, seja na poesia, como em Jesus e Pã, ou na prosa, como na biografia de Santo Agostinho. No entanto, concentrar-nos-emos no diálogo entre os “personagens” Zaratustra (Nietzsche) e o Tolo (Pascoaes), onde argumentaremos que o silêncio se manifesta na obra de ambos como um acontecimento. Um silêncio que exige, sobretudo, uma “aprendizagem”, revelando desde já o Nietzsche “educador” que Pascoaes leu. Espera-se com esse estudo demonstrar a importância de Nietzsche para a poesia de Pascoaes, viabilizando um caminho para entendermos o autor de O Pobre Tolo como um poeta do silêncio, mas sobretudo como um dos nomes responsáveis pela circulação do pensamento nietzschiano na poesia e na cultura portuguesas.
Máscara Campos e as máscaras de Campos pela perspectiva sociológica de Erving Goffman
Authors: De Paula Marcelo Ferraz , Fagundes Kelly Loreto
Published: February 2022

Segundo Goffman (1975), o meio social é uma representação contínua, que exige de nós papéis diversos em diferentes contextos. Fernando Pessoa explora com vigor esses papéis na construção e desconstrução de sua autoria poética: cria cenários, poetas-heterônimos e seus próprios acontecimentos de sensação e fingimento. Com base nessa constatação, propomos uma leitura de poemas de Álvaro de Campos, heterônimo no qual este recurso é explorado de forma recorrente. Como máscara de Pessoa, o heterônimo, por sua vez, também mascara-se e desmascara-se na poesia. Retomando estudos canônicos sobre a heteronímia pessoana, buscamos contribuir com essas leituras ao dialogarmos com a perspectiva sociológica de Goffman (1975), ressaltando a importância da máscara como problematização da instância autoral em Fernando Pessoa.
pandemia foi apenas o despertar que nos acordou a todos”
Authors: Valentim Jorge Vicente
Published: February 2022

Escrito e publicado no cerne da pandemia da covid-19, o romance Em todas as tuas te encontro (2020), do escritor português Paulo Faria, põe em evidência uma série de outros dispositivos em processo cumulativo, designados por Slavoj Zizek como “vírus ideológicos” (ZIZEK, 2020, p. 39). Num cenário devassado pela distopia (FROMM, 2009; HILARIO, 2013) de um mundo atingido por uma doença fatal, alguns desencontros, desilusões e outras moléstias (muitas experimentadas individualmente) vão se somando e acarretando, assim, outras formas de vírus (no seu sentido metafórico), num amálgama complexo dentro do corpo social: o racismo, o fascismo, a guerra colonial e o câncer. Diante dessas turbulências, algumas personagens são instadas a uma reação de resistência e de esperança, enquanto formas de tomada de consciência e de iniciativa em vislumbrar “mudanças sociais que se impõem depois de terminar a quarentena” (SANTOS, 2020, p. 15).
Intacta memória
Authors: Cirne Matthews
Published: February 2022

Este artigo tem por objetivo evidenciar alguns aspectos da poesia de Sophia de Mello Breyner Andresen, dentre os quais, o testemunho e a visão do mundo em ruínas, a partir da fragmentação temporal evidenciada nos poemas do livro No tempo dividido, publicado inicialmente em 1954, pela Guimarães Editores. As reflexões de Friedrich Nietzsche, Jean-Luc Nancy, Giorgio Agamben e Walter Benjamin darão suporte para a leitura, no que se refere à temática proposta.
memória de um corpo dilacerado
Authors: Fonseca Carlos Henrique Soares
Published: February 2022

Adoecer (2010) é um romance de Hélia Correia que reconstrói, ficcionalmente, a biografia de Elizabeth Siddal, artista vitoriana e musa dos pré-rafaelitas. No presente trabalho, pretende-se fazer uma análise de como a escrita romanesca, a partir de um diálogo entre a Literatura e História, trabalha com a doença e a complexa melancolia que atingiram o corpo de Lizzie. Entendendo este romance como um exemplo do compromisso da palavra literária em ser uma resistência ao apagamento da memória, busca-se orientar a leitura crítica desta narrativa como a possibilidade de enunciação que Siddal, metonímia de uma condição feminina comum aos Oitocentos, não encontrou em seu tempo referencialmente histórico.
Propuesta de dos metodologías para el análisis del discurso organizacional
Authors: Flores Hilda Gabriela Hernández , García Guillermo Carrera
Published: February 2022

La investigación expone dos metodologías para el análisis del discurso organizacional en situaciones de crisis. Se presentan dos casos: La Secretaría de Marina (Semar) y Frida Sofía, y el caso Cabify-Mara Castilla. El primer caso emplea el análisis de las máximas griceanas para el discurso, y el segundo, contempla la metodología de encuadres de Giddens y Mumby. La intención es comprender el alcance del discurso organizacional en el marco de una comunicación responsable, especialmente en el contexto de una crisis.