bluuebunny/crossref_metadata_2025 huggingface dataset:
Generation of immunodeficient pig with hereditary tyrosinemia type 1 and their preliminary application for humanized liver
Authors: Ren Jilong , Yu Dawei , Wang Jing , Xu Kai , Xu Yanan , Sun Renren , An Peipei , Li Chongyang , Feng Guihai , Zhang Ying , Dai Xiangpeng , Zhao Hongye , Wang Zhengzhu , Han Zhiqiang , Zhu Haibo , Ding Yuchun , You Xiaoyan , Liu Xueqin , Wu Meng , Luo Lin , Li Ziyi , Yang Yong-Guang , Hu Zheng , Wei Hong-jiang , Ge Liangpeng , Hai Tang , Li Wei
Published: March 2022

Background

Mice with humanized livers are important models to study drug toxicology testing, development of hepatitis virus treatments, and hepatocyte transplantation therapy. However, the huge difference between mouse and human in size and anatomy limited the application of humanized mice in investigating human diseases. Therefore, it is urgent to construct humanized livers in pigs to precisely investigate hepatocyte regeneration and human hepatocyte therapy. CRISPR/Cas9 system and somatic cell cloning technology were used to generate two pig models with FAH deficiency and exhibiting severe immunodeficiency (FAH/RAG1 and FAH/RAG1/IL2RG deficiency). Human primary hepatocytes were then successfully transplanted into the FG pig model and constructed two pigs with human liver.

Results

The constructed FAH/RAG1/IL2RG triple-knockout pig models were characterized by chronic liver injury and severe immunodeficiency. Importantly, the FG pigs transplanted with primary human hepatocytes produced human albumin in a time dependent manner as early as 1 week after transplantation. Furthermore, the colonization of human hepatocytes was confirmed by immunochemistry staining.

Conclusions

We successfully generated pig models with severe immunodeficiency that could construct human liver tissues.
Improved capsule routing for weakly labeled sound event detection
Authors: Li Haitao , Yang Shuguo , Wang Wenwu
Published: March 2022

Polyphonic sound event detection aims to detect the types of sound events that occur in given audio clips, and their onset and offset times, in which multiple sound events may occur simultaneously. Deep learning–based methods such as convolutional neural networks (CNN) achieved state-of-the-art results in polyphonic sound event detection. However, two open challenges still remain: overlap between events and prone to overfitting problem. To solve the above two problems, we proposed a capsule network-based method for polyphonic sound event detection. With so-called dynamic routing, capsule networks have the advantage of handling overlapping objects and the generalization ability to reduce overfitting. However, dynamic routing also greatly slows down the training process. In order to speed up the training process, we propose a weakly labeled polyphonic sound event detection model based on the improved capsule routing. Our proposed method is evaluated on task 4 of the DCASE 2017 challenge and compared with several baselines, demonstrating competitive results in terms of F-score and computational efficiency.
Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson’s disease mouse model
Authors: Lv Yi-Qing , Yuan Lin , Sun Yan , Dou Hao-Wen , Su Ji-Hui , Hou Zhi-Pan , Li Jia-Yi , Li Wen
Published: March 2022

Background

Growing evidence suggests an association between Parkinson’s disease (PD) and diabetes mellitus (DM). At the cellular level, long-term elevated levels of glucose have been shown to lead to nigrostriatal degeneration in PD models. However, the underlying mechanism is still unclear. Previously, we have elucidated the potential of type 2 diabetes mellitus (T2DM) in facilitating PD progression, involving aggregation of both alpha-synuclein (α-syn) and islet amyloid polypeptide in the pancreatic and brain tissues. However, due to the complicated effect of insulin resistance on PD onset, the actual mechanism of hyperglycemia-induced dopaminergic degeneration remains unknown.

Methods

We employed the type 1 diabetes mellitus (T1DM) model induced by streptozotocin (STZ) injection in a transgenic mouse line (BAC-α-syn-GFP) overexpressing human α-syn, to investigate the direct effect of elevated blood glucose on nigrostriatal degeneration.

Results

STZ treatment induced more severe pathological alterations in the pancreatic islets and T1DM symptoms in α-syn-overexpressing mice than in wild-type mice, at one month and three months after STZ injections. Behavioral tests evaluating motor performance confirmed the nigrostriatal degeneration. Furthermore, there was a marked decrease in dopaminergic profiles and an increase of α-syn accumulation and Serine 129 (S129) phosphorylation in STZ-treated α-syn mice compared with the vehicle-treated mice. In addition, more severe neuroinflammation was observed in the brains of the STZ-treated α-syn mice.

Conclusion

Our results solidify the potential link between DM and PD, providing insights into how hyperglycemia induces nigrostriatal degeneration and contributes to pathogenic mechanisms in PD.
Drug research and development opportunities in low- and middle-income countries: accelerating traditional medicine through systematic utilization and comprehensive synergy
Authors: Liu Guangqi , Xie Yan , Sun Yinuo , Zhang Kaixuan , Ma Jiyan , Huang Yangmu
Published: March 2022

Background

Though the utilization of traditional medicine has been proposed for modern drug research and development (R&D), limited research has discussed its feasible paths. In this commentary, we summarized key factors for new drug R&D under limited resources by reviewing China’s discovery of artemisinin, and raised suggestions to utilize traditional medicines in low- and middle-income countries (LMICs).

Main text

We suggested that systematic utilization of traditional medicine, outstanding synergy of research units at all levels and timely information-sharing mechanism should be achieved to establish a comprehensive and efficient R&D system, especially under low-resource settings. In the case of artemisinin discovery, Chinese scientists integrated documented traditional medicine experiences and modern approaches to develop drug candidates timely. Due to limited R&D resources, China adopted a collaborative way, motivating nearly all domestic research units at different levels, to develop antimalarial products. Moreover, the excellent synergy among all units through efficient information-sharing mechanisms greatly avoided work repetition and accelerated the R&D process.

Conclusion

Traditional medicines inspires drug discoveries in LMICs, while a comprehensive and efficient R&D system could accelerate its R&D process and save investment. The discovery of artemisinin in China gave a reliable pattern to promote sustainable development of traditional medicines and a good example to realize R&D of traditional medicine under low-resource settings.
Adaptation and validation of the Caregiver Burden Inventory in eating disorders
Authors: Bertelli Sara , Ferrara Paolo , Di Modica Sharon , Bergamelli Emilio , Gambini Orsola , D’Agostino Armando , Destrebecq Anne , Terzoni Stefano
Published: March 2022

Background

Living with people diagnosed with a mental disorder is known to increase the risk of developing high levels of so–called “caregiver burden” in informal caregivers. In–depth analysis of this phenomenon and specific assessment tools for caregivers of patients diagnosed with Eating Disorders (EDs) are lacking. In this study, we aimed to evaluate the psychometric properties of the Caregiver Burden Inventory in EDs and employ this adapted tool in this category of caregivers.

Methods

A cross–sectional study was conducted in the Eating Disorders outpatient unit of an Italian University hospital. Face and content validity were investigated by calculating standard Content Validity Indices (CVI-I and CVI-S) after administering the Inventory to 6 expert nurses with at least 5 years of experience in mental health services assisting people diagnosed with Eating Disorders. Internal consistency was evaluated with Cronbach’s α coefficient for the overall scale and subscales. An exploratory factor analysis (EFA) was performed to explore latent constructs. The adapted CBI was then administered to 62 informal caregivers of ED patients.

Results

The EFA yielded a 5–factor structure. The CVI-S was 97.2%; the Cronbach α coefficient was 0,90 (> 0.74 in each subscale). The median burden level in the experimental population was 40.0 [range = 21 to 54], in a theoretical range from 0 (no burden) to 96 (highest level of burden).

Conclusion

The Caregiver Burden Inventory appears to be a valid and reliable instrument to assess caregiver burden in individuals diagnosed with Eating Disorders. Further research is needed to evaluate this tool’s efficiency in improving individually tailored interventions on families.
Compensation for wind drift prevails for a shorebird on a long-distance, transoceanic flight
Authors: Linscott Jennifer A. , Navedo Juan G. , Clements Sarah J. , Loghry Jason P. , Ruiz Jorge , Ballard Bart M. , Weegman Mitch D. , Senner Nathan R.
Published: March 2022

Background

Conditions encountered en route can dramatically impact the energy that migratory species spend on movement. Migratory birds often manage energetic costs by adjusting their behavior in relation to wind conditions as they fly. Wind-influenced behaviors can offer insight into the relative importance of risk and resistance during migration, but to date, they have only been studied in a limited subset of avian species and flight types. We add to this understanding by examining in-flight behaviors over a days-long, barrier-crossing flight in a migratory shorebird.

Methods

Using satellite tracking devices, we followed 25 Hudsonian godwits (Limosa haemastica) from 2019–2021 as they migrated northward across a largely transoceanic landscape extending > 7000 km from Chiloé Island, Chile to the northern coast of the Gulf of Mexico. We identified in-flight behaviors during this crossing by comparing directions of critical movement vectors and used mixed models to test whether the resulting patterns supported three classical predictions about wind and migration.

Results

Contrary to our predictions, compensation did not increase linearly with distance traveled, was not constrained during flight over open ocean, and did not influence where an individual ultimately crossed over the northern coast of the Gulf of Mexico at the end of this flight. Instead, we found a strong preference for full compensation throughout godwit flight paths.

Conclusions

Our results indicate that compensation is crucial to godwits, emphasizing the role of risk in shaping migratory behavior and raising questions about the consequences of changing wind regimes for other barrier-crossing aerial migrants.
pH-dependent warping behaviors of ancient lacquer films excavated in Shanxi, China
Authors: Wang Kai , Liu Chongwen , Zhou Yihang , Hu Dongbo
Published: March 2022

The ancient lacquer films excavated from Dongshan Han tomb M6 of the Western Han Dynasty in Taiyuan City, Shanxi, China, were found sensitive to pH variation. This paper aims to demonstrate the pH-dependent warping behaviors of the ancient lacquer film and discuss their mechanism. The samples were analyzed by surface analytical techniques including attenuated total reflectance-Fourier transform infrared spectroscopy and X-ray photoelectron spectrometry. The results suggest that the outer layer of the lacquer film is more oxidized than the inner layer and contains more carboxylates, with calcium ions and possibly ammonium cations as counter ions. The carboxylates are speculated to be formed by oxidative cleavages in the urushiol side chains and hydrolysis of glycerides of drying oils. The shrinkage and swelling of the lacquer film can be regulated by the type of cations (H+, Ca2+, Na+) of carboxylates through hydrogen bonds, coordination bonds and static forces. Due to the higher content of carboxylates in the outer part, it shrinks more at low pH causing warping outward and swells more at high pH causing warping inward. This paper may provide an important reference for pH control and help resolve the warping problem during conservation or restoration of ancient lacquerware.
Evaluation of interproximal reduction in individual teeth, and full arch assessment in clear aligner therapy: digital planning versus 3D model analysis after reduction
Authors: Hariharan Amirtha , Arqub Sarah Abu , Gandhi Vaibhav , Da Cunha Godoy Lucas , Kuo Chia-Ling , Uribe Flavio
Published: March 2022

Aim

To evaluate the correspondence between the interproximal reduction (IPR) performed clinically and that programmed in ClinCheck® and further assess which teeth showed an amount of implemented IPR (I-IPR) that corresponds with that programmed in ClinCheck®.

Materials and methods

Pre- (T0) and post-treatment (T1) ClinCheck® digital models for 75 subjects (30 males and 45 females), mean age (38 ± 15) years, were included. To calculate the amount of I-IPR, Ortho Analyzer software (3Shape, Copenhagen, Denmark) was used to measure the mesiodistal widths for the maxillary and mandibular teeth from second premolar to the contralateral second premolar on the initial (T0) and final (T1) STL models. I- IPR performed by tooth was obtained by comparing the mesiodistal width of each tooth at T0 and T1. The amount of programmed IPR (P-IPR) in ClinCheck® was compared to that implemented clinically using the following formula: IPR difference = (P-IPR) − (I-IPR).

Results

Statistically significant differences were observed between the average value of digitally programmed and implemented IPR per tooth for both the maxillary (p < .0001) and mandibular (p < .0001) teeth. The mean P-IPR for the maxillary teeth was 0.28 ± 0.16 mm versus the mean I-IPR of 0.15 ± 0.15 mm. In the mandibular arch, the mean P-IPR was 0.31 ± 0.17 mm, while the I-IPR was 0.17 ± 0.16 mm. The mean I-IPR was consistently lower than the mean P-IPR regardless of teeth and sites (p < 0.0001). The difference between the P-IPR compared to the I-IPR was larger for mandibular anterior teeth than for maxillary anterior teeth (p = 0.0302) and larger for maxillary posterior teeth than mandibular posterior teeth (p = 0.0059).

Conclusion

The amount of implemented-IPR in clear aligner therapy is less than that digitally programmed for most teeth. Regardless of the regions, I-IPR was consistently lower than that programmed. Mandibular anterior teeth and maxillary posterior teeth showed greater discrepancy between P-IPR and I-IPR than the maxillary anterior and mandibular posteriors. Further prospective studies are needed to determine the factors affecting the precision of IPR and the clinical implications of a significantly reduced I-IPR on treatment outcomes.
Motivation to learn by age, education, and literacy skills among working-age adults in the United States
Authors: Yamashita Takashi , Smith Thomas J. , Sahoo Shalini , Cummins Phyllis A.
Published: March 2022

This study highlighted how particular intersections of personal characteristics were related to Motivation to Learn (MtL) among adults. MtL is a prerequisite for adult education and training participation. However, little is known about MtL across subpopulations due to several methodological limitations. This study developed a national profile of MtL by key subpopulations that are defined by combinations of age, gender, education level, and literacy proficiency in the United States. Data were obtained from 2012/2014/2017 Program for International Assessment of Adult Competencies (PIAAC) restricted use file (N = 8400). The alignment optimization (AO) method was employed to estimate subpopulation means of a PIAAC-based latent MtL construct. Subpopulations with younger age, greater educational attainment, and higher literacy proficiency showed significantly greater MtL.
New avenues of sepsis research: obtaining perspective by analyzing and comparing SSCG 2021 and J-SSCG 2020
Authors: Yatabe Tomoaki , Egi Moritoki , Ogura Hiroshi
Published: March 2022

Recently, revisions of two sepsis guidelines, namely, the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 and the Surviving Sepsis Campaign Guidelines 2021, were published. Although both guidelines were created in accordance with the Grading of Recommendations, Assessment, Development and Evaluation approach, the evidence-to-decision tables differed between them. In addition, certain recommendations may differ between these guidelines for similar clinical questions because of differences in the “PICO” criteria. Other differences in recommendations between the two guidelines are due to unclear evidence, and these ambiguities may provide the basis for further sepsis research. We hope that these two guidelines will contribute to the creation of new clinical evidence in addition to supporting treatment of patients with sepsis.
Comparison between two solute equations and bioimpedance for estimation of body fluid volumes
Authors: Hahn Robert G. , Giménez-Milà Marc
Published: March 2022

Background

The extracellular volume (ECV) and intracellular volume (ICV) estimated by bioimpedance analysis (BIA) deviates markedly from the textbook volumes of 20% and 40% of the body weight (BW). We estimated the transcellular exchange of water by calculating solute equilibriums after fluid challenges to examine whether the BIA or the textbook volumes are likely to be most correct.

Methods

Data was retrieved from 8 healthy male volunteers who received 25 mL/kg of Ringer’s solution or 3–5 mL/kg of hypertonic (7.5%) saline over 30 min after the ECV and ICV had been estimated by BIA. The exchange of water between the ECV and the ICV was calculated according to a sodium equation and an osmolality equation. Simulations were performed, where deviating body fluid volumes were applied.

Results

The mean ECV measured with BIA was 24.9% of BW (p < 0.05 versus the “textbook” volume). Mean ICV measured with BIA was 22.3% of BW (p < 0.05). The sodium and osmolality equations correlated closely with respect to the translocation of water across the cell membrane (r2 = 0.86). By applying the “textbook” ECV, the sodium equation indicated that Ringer’s solution exchanged negligible amounts of water, while hypertonic saline withdrew 1.4 L from the ICV to the ECV. By contrast, applying the BIA-derived ECV to the sodium equation implied that 3 L of water would be translocated from the ECV to the ICV once hypertonic saline was administered.

Conclusion

The “textbook” ECV and ICV volumes but not the BIA-derived volumes were consistent with the fluid shifts obtained by two solute equations.
Imaging crustal features and Moho depths through enhancements and inversion of gravity data from the Philippine island arc system
Authors: Casulla Mel Anthony A. , Mizunaga Hideki , Tanaka Toshiaki , Dimalanta Carla B.
Published: March 2022

The Philippine archipelago is a complex island arc system, where many regions still lack geopotential field studies. The high-resolution isostatic anomaly and free-air anomaly digital grids from the World Gravity Map (WGM) were processed and analyzed to present a general discussion of the Philippines’ gravity signatures and contribute to understanding its regional geology and tectonics. The isostatic anomaly map was continued upward to investigate the high-density ophiolitic basement rocks and low-gravity sedimentary basins at depth. The first vertical derivative (1VD) filter was applied to the free-air anomaly grid map to locate regional structures represented by density contrast boundaries. The depth to the top of the Moho and basement rock over the Sulu Sea was computed using the two-dimensional (2-D) radially averaged power spectrum analysis. Three-dimensional (3-D) gravity inversion was applied to some major sedimentary basins in the Philippines to present 3-D subsurface density contrast models. The interpreted gravity maps highlighted prominent geologic features (e.g., trench manifestation, ophiolite distribution, basin thickness). The negative isostatic anomalies (< 0 mGal) represent the thick sedimentary basins, while the moderate signatures (0 to 80 mGal) correspond to the metamorphic belts. The distinct very high-gravity anomalies (> 80 mGal) typify the ophiolitic basement rocks. The gravity data’s upward continuation revealed contrasting deep gravity signatures; the central Philippines with continental affinity (with 20–35 mGal) was distinguished from the regions with oceanic affinity (with 45–200 mGal). The 1VD map over the Sulu Sea showed anomalies associated with shallow features dominantly related to the Cagayan Ridge. The 2-D radially averaged power spectrum analysis exposed gravity anomalies with tectonic significance (e.g., basement characterization, Moho depth estimation). The estimated average Moho depth in the Sulu Sea is from 12 to 22 km, while the average basement depth is within the range of 5 to 11 km. Lastly, the 3-D subsurface density contrast models characterized the very low-density zones representing the deep (> 7 km) sedimentary basins in the northern Cagayan Valley and southern Central Luzon basins. Furthermore, thin (~ 3.5 km) sedimentary formations are inferred for the low-density areas in northern Agusan-Davao and eastern Cotabato basins.
Biomechanical and Musculoskeletal Measurements as Risk Factors for Running-Related Injury in Non-elite Runners: A Systematic Review and Meta-analysis of Prospective Studies
Authors: Peterson Benjamin , Hawke Fiona , Spink Martin , Sadler Sean , Hawes Morgan , Callister Robin , Chuter Vivienne
Published: March 2022

Background

Running-related injury (RRI) is highly prevalent among recreational runners and is a key barrier to participation. Atypical lower limb alignment and mechanical function have been proposed to play a role in development of lower extremity injury. The purpose of this study was to investigate relationships between incidence of running-related injury (RRI) in non-elite runners with biomechanical and musculoskeletal variables.

Methods

A systematic review and meta-analysis of prospective studies. Published research indexed in MEDLINE, EMBASE, CINAHL, SPORTDiscus, AMED, and The Cochrane library until 13th January 2021, grey literature, and reference lists of included studies were screened to identify prospective studies of non-elite adult runners that measured a relationship between biomechanical or musculoskeletal measures and incidence of RRI.

Results

Thirty studies (3404 runners), testing over 100 discrete biomechanical and musculoskeletal risk factors for RRI, were included. Nineteen studies were pooled in twenty-five separate meta-analyses. Meta-analysis of four studies detected significantly less knee extension strength among runners who developed a RRI (SMD − 0.19, 95% CI − 0.36 to − 0.02, p = 0.03), though this may not be clinically important. A meta-analysis of two studies detected significantly lower hip adduction velocity among runners who developed a RRI (MD − 12.80, 95% CI − 25.22 to − 0.38, p = 0.04). Remaining meta-analyses found no significant relationship between biomechanical or musculoskeletal variables and RRI.

Conclusion

This systematic review and meta-analysis found the currently available literature does not generally support biomechanical or musculoskeletal measures as risk factors for RRI in non-elite runners. While meta-analysis findings for knee extension strength and hip adduction velocity as risk factors for RRI were statistically significant, the associated trivial to small effects sizes suggest these findings should be treated with caution. Until further evidence emerges, recommendations for injury prevention in non-elite runners cannot be made based on biomechanical and musculoskeletal measurements alone.
Phytochemical characterization and evaluation of Antiurolithiatic activity of selected source plants of Pashanabheda
Authors: C. T Sulaiman , C. K Jyothi , G Jinu Krishnan Unnithan , K. M Prabhukumar , Balachandran Indira
Published: March 2022

Background

Pashanabhedais an importantAyurvedicdrug known for diuretic and lithotriptic properties. The botanical identity of this drug is controversial as many plants likeBergenia ciliata(BC),Rotula aquatica(RA),Aerva lanata(AL) andPlectranthus amboinicus(PA) are being used as its source plants in different parts of India. This study aims at comparative phytochemical and pharmacological evaluation of various source plants ofPashanabheda.

Methods

Comparative phytochemical analysis and evaluation of Antiurolithiatic activity was carried out in selected medicinal plants used asPashanabheda. Chemical profiling was done by HPTLC analysis and characterization of major constituents was done using liquid chromatography based tandem mass spectroscopic analysis. Antiurolithiatic activity was evaluated by ethylene glycol induced urolithiasis in experimental animal model.

Results

Phytochemical studies showed that there is no significant correlation on chemical constituents of selected species. Certain common bands were observed for BC and RA on HPTLC profiling. Tandem mass spectroscopic characterization of various species showed presence of several polyphenolics in selected species. BothBergenia ciliataandA. lanatapossessed substantial antiurolithiatic activity compared to other species.A. lanataextract at doses of 100 and 200 mg/kg, showed significant activity against ethylene glycol induced changes serum and urine biochemistry and also significantly prevented ethylene glycol induced damage to nephrons in experimental animals.

Conclusions

Aerva lanatacontains many active phytochemicals and showed significant antiurolithiatic activity. The findings of this study may lead to the possibility of consideringAerva lanataas a validated alternative source forPashanabheda.
Migration drivers and migration choice: interrogating responses to migration and development interventions in West Africa
Authors: Black Richard , Bellagamba Alice , Botta Ester , Ceesay Ebrima , Cissokho Dramane , Engeler Michelle , Lenoël Audrey , Oelgemöller Christina , Riccio Bruno , Sakho Papa , Somparé Abdoulaye Wotem , Vitturini Elia , Zingari Guido Nicolas
Published: March 2022

The notion of migration as being at least partly about ‘choice’ is deeply rooted in both academic thought and public policy. Recent contributions have considered migration choice as step-wise in nature, involving a separation between ‘aspiration’ and ‘ability’ to migrate, whilst stressing a range of non-economic factors that influence migration choices. But such nuances have not prevented the emergence of a significant area of public policy that seeks to influence choices to migrate from Africa through ‘irregular’ channels, or at all, through a range of development interventions. This paper explores evidence from West Africa on how young people formulate the boundaries of such choice. Drawing on approaches in anthropology and elsewhere that stress the value of a ‘future-orientated’ lens, we show how present uncertainty is a central framing that fundamentally limits the value of thinking about migration as a choice. This has important implications for policy on ‘migration and development’.
Phase field assisted analysis of a solidification based metal refinement process
Authors: Viardin A. , Böttger B. , Apel M.
Published: March 2022

Ultra pure metals have various applications, e. g. as electrical conductors. Crystallization from the melt, e. g. via zone melting, using the segregation of impurities at the solidification front is the basic mechanism behind different technical processes for the refining of metals and semi-metals. In this paper, we focus on a crystallization methodology with a gas cooled tube (“cooled finger”) dipped into a metallic melt in a rotating crucible. The necessary requirement for purification in a solidification process is a morphologically stable solidification front. This is the only way to enable macroscopic separation of the impurities, e. g. by convection. For cellular or dendritic solidification morphologies, the segregated impurities are trapped into the interdendritic melt and remain as microsegregations in the solidified metal. Morphological stability depends on the temperature gradient G at the solidification front, the solidification front velocity V front and thermodynamic alloy properties like the segregation coefficients of the impurity elements. To quantify the impact of these parameters on the morphological evolution, especially on the planar/cellular transition and thus on microsegregation profiles, phase field simulations coupled to a thermodynamic database are performed for an aluminium melt with three impurities, Si, Mn and Fe. In particular, we have investigated the morphology evolution from the start of solidification at the cooled finger towards a stationary growth regime, because in the technical process a significant fraction of the melt solidifies along the initial transient. To solve the transient long range temperature evolution on an experimental length scale, the temperature field has been calculated using the homoenthalpic approach together with a 1D temperature field approximation. The simulations provide the process window for an energy efficient purification process, i. e. low thermal gradients, and elucidate the benefit of melt convection.
Psychometric properties of the PROMIS Preference score (PROPr) in patients with rheumatological and psychosomatic conditions
Authors: Klapproth C. P. , Fischer F. , Merbach M. , Rose M. , Obbarius A.
Published: March 2022

Background

The PROMIS Preference score (PROPr) is a new generic preference-based health-related quality of life (HRQoL) score that can be used as a health state utility (HSU) score for quality-adjusted life years (QALYs) in cost-utility analyses (CUAs). It is the first HSU score based on item response theory (IRT) and has demonstrated favorable psychometric properties in first analyses. The PROPr combines the seven PROMIS domains: cognition, depression, fatigue, pain, physical function, sleep disturbance, and ability to participate in social roles and activities. It was developed based on preferences of the US general population. The aim of this study was to validate the PROPr in a German inpatient sample and to compare it to the EQ-5D.

Methods

We collected PROPr and EQ-5D-5L data from 141 patients undergoing inpatient treatment in the rheumatology and psychosomatic departments. We evaluated the criterion and convergent validity, and ceiling and floor effects of the PROPr and compared those characteristics to those of the EQ-5D.

Results

The mean PROPr (0.26, 95% CI: 0.23; 0.29) and the mean EQ-5D (0.44, 95% CI: 0.38; 0.51) scores differed significantly (d = 0.18, p < 0.001). Compared to the EQ-5D, the PROPr scores were less scattered across the measurement range which has resulted in smaller confidence intervals of the mean scores. The Pearson correlation coefficient between the two scores was r = 0.72 (p < 0.001). Both scores showed fair agreement with an Intraclass Correlation Coefficient (ICC) of 0.48 (p < 0.05). The PROPr and EQ-5D demonstrated similar discrimination power across sex, age, and conditions. While the PROPr showed a floor effect, the EQ-5D showed a ceiling effect.

Conclusion

The PROPr measures HSU considerably lower than the EQ-5D as a result of different construction, anchors and measurement ranges. Because QALYs derived with the EQ-5D are widely considered state-of-the-art, application of the PROPr for QALY measurements would be problematic.
Neuropsychiatric lupus erythematosus in a cohort of Egyptian patients
Authors: Ragab Salma M. , Ibrahim Amira M.
Published: March 2022

Background

The neuropsychiatric lupus erythematosus (NPSLE) is a severe complication of systemic lupus erythematosus (SLE) that is characterized by a variety of neurological manifestations involving both central and peripheral nervous system with variable mechanisms. This study aimed to investigate the frequency of NPSLE and its relation to other clinical and laboratory findings in SLE patients.

Results

We retrieved the medical records of 134 SLE patients during the study period; of them, 68 patients (50.7%) had NPSLE. Headache (55. 9%) was the most frequent NPSLE manifestation followed by seizures (54.4%), psychosis was the third most frequent one with a percentage of 41.2. The demographic data didn’t differ in patients with and without NPSLE. NPSLE patients had lower complement 3 (C3) (p = 0.025) and C4 (p = 0.008) levels, more lupus anticoagulant level (p = 0.033) and more frequency of antiphospholipid syndrome (p = 0.030). There was no statistical difference regarding the drug intake or other laboratory findings. Disease activity and damage indices didn’t differ in both groups.

Conclusion

The prevalence of NPSLE in this study was 50.7%. Headache, seizures and psychosis were the most frequent neuropsychiatric manifestations in the studied patients. SLE patients with neuropsychiatric manifestations had lower complement levels, higher lupus anticoagulant antibodies and antiphospholipid syndrome.
Enabling citizens’ Right to the Smart City through the co-creation of digital platforms
Authors: Leclercq Els M. , Rijshouwer Emiel A.
Published: March 2022

In response to increasingly deterministic and all-encompassing implementation of smart city technologies, scholars and activists plea for policies and initiatives to support citizens’ democratic ‘Right to the Smart City.’ Although it is common for government officials and technology companies to make an effort to support citizen participation in smart city development, the question is how this works in practice. The authors engaged in a series of three participatory action research projects with the aim to support citizens’ ‘Right to the Smart City’ through the development and use of digital platforms. We find that, although (the processes of co-creatively developing) these platforms do actively address citizens’ engagement, empowerment and emancipation in smart city development, their contribution to provide participants with the opportunity to actually and sustainably reframe, reimagine and remake the smart city in a way that benefits them and their communities, is fairly limited. We conclude that time and budget constraints, entrenched technocratic beliefs, as well as vested – traditional – and imbalanced power relationships and divergent views, concerns and objectives prohibit citizens’ ‘Right to the Smart City.’ Hence, our plea for ‘Governance Beyond Participation:’ city making processes that do not perceive citizens as participants or clients, but as valued and trustworthy collaborators in the development and the governance of public space.
Correlation between chest CT scores and clinical impact in patients re-infected with COVID-19 during the two attacks: an observational study
Authors: Fatouh Mona Mohammed , Kandil Nour Mohamed , EL Garhy Nermeen Mahmoud
Published: March 2022

Background

Worldwide, millions of people got COVID-19 infection since the start of the pandemic with a large number of deaths. Re-infection with SARS-CoV-2 is possible, because it can mutate into new strains as it is an RNA virus. The main objective of our study is to correlate between CT severity score of the patients re-infected with COVID-19 during the first and second attack and its clinical impact.

Results

We performed a retrospective cohort study. It was carried out on fifty symptomatic patients (11 females and 39 males). Their ages ranged from 38 to 71 years. We included only patients who were re-infected after more than 6 months of the first infection and showed clinical symptoms with SARS-CoV-2 PCR-positive test. We found that CT severity score was decreased in the second infection in 47 (94%) of our patients associated with decreased respiratory distress as well as oxygen requirements, while the CT severity score was increased in two patients and only one patient showed no change in CT score severity between two infections.

Conclusion

The reduction in CT severity score in the majority of re-infected patients suggested the role of the immunity developed from first infection in protection against severe lung affection in case of repeated infection even after 6 months despite poor immunity against re-infection.
Various vaccine platforms in the field of COVID-19
Authors: Savina K. , Sreekumar Rakhy , Soonu V. K. , Variyar E. J.
Published: March 2022

Background

With the emergence of Corona virus Disease-2019, a novel worldwide health disaster is threatening the population. The WHO declared COVID-19 as a pandemic in December 2019, when it first surfaced in Hunan seafood market in Wuhan, South China, and quickly spread far and wide. Different corona virus variants are currently causing concern all across the world.

Main body

It has become critical for our scientists to develop a viable method to prevent infection or the pandemic from spreading globally. Antiviral medicines, oxygen therapy, and immune system stimulation are all used to treat the condition. SARS-CoV-2 undergoes mutation and due to evolutionary pressures, different mutant strains caused various symptoms in different geographical regions and the epidemic is spreading and becoming more fragile, posing a greater risk of mortality. Vaccines are tools to increase our immunity as a precaution, and increasing the global immunization rate can help improve the situation. Recent developments in the field of vaccine platforms are discussed here.

Short conclusion

Vaccines are of highest priority to control and eradicate the viral infectious disease COVID-19 more than any other protective solutions. A number of mutations have occurred and some variants such as alpha, beta, gamma, and delta, and it has now progressed to the new version Omicron, which is a variant of concern. Booster doses are anticipated to function as a barrier to the capacity of the most recent known variety, and more research is needed to determine how effective they will be. This page discusses various technologies employed in the field of COVID-19 vaccine, as well as potential barriers and recent developments in this field.
Congenital hernia of umbilical cord with patent vitellointestinal duct along with evisceration of gut—a rare presentation and unusual management
Authors: Kumar Chandrodaya , Ali Md Mokarram , Kadian Yogender Singh
Published: March 2022

Background

Congenital hernia of umbilical cord is a rare congenital anomaly. Due to its presentation as herniation of small bowel or other viscera into the umbilical cord, it is often misdiagnosed as omphalocele minor.

Case presentation

We are reporting a rare case of congenital hernia of umbilical cord which presented with rupture of hernia sac and evisceration of small bowel loops with reverse ileal intussusception via a patent vitellointestinal duct. It was managed by first repositioning the gut with stoma at umbilical site as a temporizing measure followed by definitive surgery in the form of resection of patent vitellointestinal duct and end to end ileal anastomosis.

Conclusion

Congenital hernia of umbilical cord with patent vitellointestinal duct is a rare abdominal wall defect which can present beyond neonatal period with evisceration of gut. A high index of suspicion should be kept by the first attending clinician to avoid a delay in management.
Nasogastric tube feeding under physical restraint on paediatric wards: ethical, legal and practical considerations regarding this lifesaving intervention
Authors: Fuller Sarah J. , Chapman Simon , Cave Emma , Druce-Perkins James , Daniels Poppy , Tan Jacinta
Published: March 2022

Eating disorders have the highest mortality rate of any psychiatric condition. Since the COVID-19 pandemic, the number of patients who have required medical stabilisation on paediatric wards has increased significantly. Likewise, the number of patients who have required medical stabilisation against their will as a lifesaving intervention has increased. This paper highlights a fictional case study aiming to explore the legal, ethical and practical considerations a trainee should be aware of. By the end of this article, readers will be more aware of this complex issue and how it might be managed, as well as the impact it can have on the patient, their family and ward staff.
Variations in COVID-19 vaccination uptake among people in receipt of psychotropic drugs: cross-sectional analysis of a national population-based prospective cohort
Authors: Murphy Siobhán , O'Reilly Dermot , Owen Rhiannon K. , Akbari Ashley , Lowthian Emily , Bedston Stuart , Torabi Fatemeh , Beggs Jillian , Chuter Antony , de Lusignan Simon , Hobbs Richard , Robertson Chris , Katikireddi Srinivasa Vittal , Sheikh Aziz , Bradley Declan T.
Published: March 2022

Background

Coronavirus disease 2019 (COVID-19) has disproportionately affected people with mental health conditions.

Aims

We investigated the association between receiving psychotropic drugs, as an indicator of mental health conditions, and COVID-19 vaccine uptake.

Method

We conducted a cross-sectional analysis of a prospective cohort of the Northern Ireland adult population using national linked primary care registration, vaccination, secondary care and pharmacy dispensing data. Univariable and multivariable logistic regression analyses investigated the association between anxiolytic, antidepressant, antipsychotic, and hypnotic use and COVID-19 vaccination status, accounting for age, gender, deprivation and comorbidities. Receiving any COVID-19 vaccine was the primary outcome.

Results

There were 1 433 814 individuals, of whom 1 166 917 received a COVID-19 vaccination. Psychotropic medications were dispensed to 267 049 people. In univariable analysis, people who received any psychotropic medication had greater odds of receiving COVID-19 vaccination: odds ratio (OR) = 1.42 (95% CI 1.41–1.44). However, after adjustment, psychotropic medication use was associated with reduced odds of vaccination (ORadj = 0.90, 95% CI 0.89–0.91). People who received anxiolytics (ORadj = 0.63, 95% CI 0.61–0.65), antipsychotics (ORadj = 0.75, 95% CI 0.73–0.78) and hypnotics (ORadj = 0.90, 95% CI 0.87–0.93) had reduced odds of being vaccinated. Antidepressant use was not associated with vaccination (ORadj = 1.02, 95% CI 1.00–1.03).

Conclusions

We found significantly lower odds of vaccination in people who were receiving treatment with anxiolytic and antipsychotic medications. There is an urgent need for evidence-based, tailored vaccine support for people with mental health conditions.
Administration of Immune Checkpoint Inhibitors Near the End of Life
Authors: Bloom Matthew D. , Saker Haneen , Glisch Chad , Ramnaraign Brian , George Thomas J. , Markham Merry J. , Kelkar Amar H.
Published: March 2022

PURPOSE:

Recent literature suggests an increasing use of systemic treatment in patients with advanced cancer near the end of life (EOL), partially driven by the increasing adoption of immune checkpoint inhibitors (ICIs). While studies have identified this trend, additional variables associated with ICI use at EOL are limited. Our aim was to characterize a population of patients who received a dose of ICI in the last 30 days of life.

METHODS:

We performed a manual retrospective chart review of patients ≥ 18 years who died within 30 days of receiving a dose of ICI. Metrics such as Eastern Cooperative Oncology Group performance status (ECOG PS), number of ICI doses, need for hospitalization, and numerous other variables were evaluated.

RESULTS:

Over a 4-year time period, 97 patients received an ICI at EOL. For 40% of patients, the ICI given in the 30 days before death was their only dose. Over 50% of patients had an ECOG PS of ≥ 2, including 17% of patients with an ECOG PS of 3. Over 60% were hospitalized, 65% visited the emergency department, 20% required intensive care unit admission, and 25% died in the hospital.

CONCLUSION:

Our study contributes to the ongoing literature regarding the risks and benefits of ICI use in patients with advanced cancer near the EOL. While accurate predictions regarding the EOL are challenging, oncologists may routinely use clinical factors such as ECOG PS along with patient preferences to guide recommendations and shared decision making. Ultimately, further follow-up studies to better characterize and prognosticate this population of patients are needed.
Treatment Strategies for Advanced Classical Hodgkin Lymphoma in the Times of Dacarbazine Shortage
Authors: Torka Pallawi , Przespolewski Eugene , Evens Andrew M.
Published: March 2022

The shortage of dacarbazine (DTIC) has created an acute and unprecedented crisis in the management of patients with classical Hodgkin lymphoma, with DTIC being an essential component of doxorubicin, bleomycin, vinblastine, and DTIC (ABVD) and prior attempts at omitting DTIC from ABVD leading to substantial loss of efficacy. In this review, we discuss the strategies to manage classical Hodgkin lymphoma during the DTIC shortage and propose a treatment algorithm on the basis of fitness and ability to receive anthracyclines safely.
Reports from China: Joan Robinson as Observer and Travel Writer, 1953–78
Authors: Boianovsky Mauro , Serra Gerardo
Published: March 2022

Joan Robinson's infatuation with Mao's China remains the most controversial episode of the Cambridge economist's life. Drawing on the literatures on observation in science and economics, and economists' travels, we aim to overcome the dichotomy between Robinson as a political pilgrim and Robinson as a development economist. Instead, we take a closer look at her observation practices, her literary choices, and her position within different political and intellectual communities. The structure of the article is quasi chronological: each trip to China is both described in its own right and treated as an entry point to shed light on a particular aspect of Robinson's engagement with the country.
The Economic Impact of the Black Death
Authors: Jedwab Remi , Johnson Noel D. , Koyama Mark
Published: March 2022

The Black Death was the largest demographic shock in European history. We review the evidence for the origins, spread, and mortality of the disease. We document that it was a plausibly exogenous shock to the European economy and trace out its aggregate and local impacts in both the short run and the long run. The initial effect of the plague was highly disruptive. Wages and per capita income rose. But, in the long run, this rise was only sustained in some parts of Europe. The other indirect long-run effects of the Black Death are associated with the growth of Europe relative to the rest of the world, especially Asia and the Middle East (the Great Divergence), a shift in the economic geography of Europe toward the northwest (the Little Divergence), the demise of serfdom in western Europe, a decline in the authority of religious institutions, and the emergence of stronger states. Finally, avenues for future research are laid out. (JEL N13, N30, N43, J10, I12, I14, I30)
Anatomy in present times: A satire
Authors: Huma Zilli
Published: March 2022

doi: https://doi.org/10.12669/pjms.38.4.5799

How to cite this:Huma Z. Anatomy in present times: A satire. Pak J Med Sci. 2022;38(4):---------. doi: https://doi.org/10.12669/pjms.38.4.5799

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.