bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship between Mindfulness and Burnout among Chinese Pilots: Multiple Mediation through Fatigue and Proactive Coping
Authors: Guo Yaning , Ji Ming , Yang Zhiwei , Wang Hui , You Xuqun
Published: March 2021

Objective: The present study aimed to examine a possible relationship between mindfulness and burnout among Chinese civil pilots, and to investigate the mediating effects of fatigue and proactive coping.Background: Based on the perspective of the extended job demand–resource model, the current study has extended prior research for identifying the mechanism underlying the roles of personal resource and personal stress in the association between mindfulness and burnout.Method: A representative sample of 319 civil pilots drawn from the China Southern Airlines accomplished self-administrated questionnaires. Structural Equation Modeling (SEM) was used to test the hypothesized multiple mediation model with Mplus 8.3.Results: Results addressed consistent evidence that mindfulness would play an important part in relieving and preventing burnout. A multiple mediation model showed that mindfulness exerted its indirect effect on burnout through fatigue and proactive coping, χ2 = 940.495, df = 660, χ2/df = 1.425, TLI = .940, CFI = .944, SRMR = .045, RMSEA = .037. Moreover, fatigue mediated the effect of mindfulness on burnout (β = -.074, 95%CI = -.106 to -.036), whereas proactive coping mediated the association between mindfulness and burnout (β = -.842, 95%CI = -1.215 to -.635). Consequently, findings corroborated a predictive role of fatigue and proactive coping, both independently and jointly, in the indirect effect that mindfulness exerted effects on burnout.Conclusion: Theoretical implications in the extended job demand-resource model and practical recommendations for mindfulness training practice and fatigue reduction program were discussed.
Assessing the Outcome of Management of Thyroid Dysfunction in Pregnancy With Second Affiliated Hospital of Chongqing Medical University Guideline.
Authors: Obiegbusi Samuel Chigbo , Dong Xiao Jing , Deng Ming yu , Obiegbusi Chidera Nneji , Yang Yin , Deng Xinru
Published: March 2021

Introduction – Pregnancy comes with hormonal changes which, when not properly managed, could lead to complications. Thyroid hormone is one of the hormones that are affected during pregnancy, and it plays a significant role in pregnancy, from conception to delivery. In a bid to identify intended pregnant women and pregnant women with thyroid dysfunction, the Endocrinology Branch of Chinese Medical Association and Perinatal medicine branch of Chinese Medical Association set guidelines for diagnosis and treatment of thyroid diseases in pregnancy and postpartum women. The guideline recommends screening for all women who desire getting pregnant soon and pregnant women, which Second Affiliated Hospital of Chongqing Medical University is implementing.Purpose - To Identify the common thyroid disease found among pregnant women in Chongqing. Evaluate the effectiveness of the management guideline toward improving pregnancy outcome among women diagnosed with thyroid disease during their pregestational and gestational period, and ascertain the need for additional measures to be taken towards thyroid disease management during pregnancy in certain areas with unfavourable outcome.Method – A retrospective cohort study of 774 pregnant women diagnosed with thyroid dysfunction in the Second Affiliated Hospital of Chongqing Medical University from 2016 -2018 was extracted from the hospital computer patient’s record. Only 724 patients that met the inclusive criteria were analysed. Participants were grouped into four, according to the time they were diagnosed and managed. The Multiple logistic regression and binary logistic regression statistical analysis were done with SPSS, and we adjusted for potential confounders, including maternal age, parity, and gravida.Result – There is an association between maternal age and abortion among pregnant women diagnosed with subclinical hypothyroidism, P-0.018(OR 1.459, 95%CI 1.067-1.997) and significant difference in pregnant women who developed intrauterine growth restriction after being diagnosed with hypothyroidism in the second trimester, P-0.048(OR-0.152, 95%CI 0.024-0.981). There was also a significant difference in gravida, P-0.032(OR 1.368, 95%CI 1.028 1.821) and normal delivery mode, P-0.010(OR 2.521, 95%CI 1.246-5.100).Conclusion – The study shows a promising result as less complication is observed. However, more attention is needed toward managing subclinical hypothyroidism in pregnancy to curb abortion/miscarriage incidence. Hypothyroidism in second trimester could lead to intrauterine growth restriction. Multigravida increases the risk of complication among pregnant women with thyroid dysfunction.
Genesis and Influencing Factors of the Colour of Chrysoprase: Colourimetric Analysis Based on the Cie 1976 L*a*b* Uniform Colour Space
Authors: Jiang Yuansheng , Guo Ying
Published: March 2021

The colour of chrysoprase is produced by Ni cations and influenced by other transition-metal cations and crystallinity. Presented here is a study of the origin of chrysoprase colour and an exploration of the factors that influence it from the perspective of gemstone chromaticity. Transmission electron microscopy and X-ray fluorescence, ultraviolet–visible and Raman spectroscopies are used to investigate 41 gem-quality chrysoprase samples, and the results show that chrysoprase colour results from nanometre-size inclusions of pimelite. Under a 6504-K fluorescent lamp, chrysoprase colour is divided into the grades of fancy, fancy intense and fancy deep. The lightness of chrysoprase is affected mainly by its Cr content, the chroma is affected by its Ni content and the hue angle is affected by the sum of its Cr and Fe contents. Chrysoprase hue and chroma are related significantly to the transmission window that occurs between the two main bands centred at 380 and 660 nm and the absorption peak at 660 nm in the ultraviolet–visible spectrum. Chrysoprase with low crystallinity has more Ni and a higher chroma.
The diagnostic value of the TNI-93: a memory test suitable for both literate and illiterate patients.
Authors: FOUCARD CENDRINE , Palisson Juliette , Belin Catherine , Bereaux Chloé , Dumurgier Julien , Paquet Claire , Degos Bertrand , Bouaziz-Amar Elodie , Maillet Didier , Houot Marion , Garcin Béatrice
Published: March 2021

Background: A significant proportion of Alzheimer disease (AD) patients are illiterate or poorly educated, and only a few memory tests are adapted for these patients. The TNI-93 is a quick memory test that was designed for all patients regardless of their education level. In the present study we aimed at assessing the diagnostic value of the TNI-93 for the screening and diagnosis of patients with biologically confirmed amyloid status.Method: We included all patients who had a lumbar puncture (LP) for the analysis of AD cerebrospinal fluid (CSF) biomarkers, a full neuropsychological assessment that included the TNI-93 and an anatomical brain imaging (MRI/CT scan) at Avicenne Hospital between January 2009 and November 2019. We compared the TNI-93 scores in A+ patients (patients with amyloid abnormalities) and A- patients according to the A T (N) criteria (NIA-AA 2018). We also compared A+T+ patients to A-T- patients.Results: 108 patients were included with a mean age of 66.9 ± 8.5 years old, and mean education level of 8.9 ± 5.16 years, illiterate patients represented 27% of the population. Patients from the A+ group (N= 80) were significantly more impaired than patients from the A- group (N=28) on immediate recall (A+: 5.9±2.8; A-: 7.4±2.6; p=0.001), free recall (A+: 3.5±2.7; A-: 5.9±2.8; p< 0.001), total recall (A+: 5.7±3.5; A-: 7.8±2.8; p< 0.001) and on number of intrusions during the recall phase (A+: 1±1.8; A-: 0.1±0.3; p=0.002). Similar results were observed in the memory subgroup but not in patients with presentation other than memory complaint (ie language impairment or others presentation such as behavioural and hallucination). Similar results with increased significance were observed when we compared A+T+ patients (N=50) to A-T- patients (N=26). Analyses of the ROC curves revealed that the best scores of the TNI-93 test to discriminate A+ patients from A- were immediate recall (Area under curve (AUC): 0.70), free recall (AUC: 0.74) and total recall (AUC: 0.74).Conclusion: We found that the TNI-93’s immediate recall, free and total recall are valuable for the diagnosis of amyloid pathology suggestive of AD.
Cat-crnp as New Material With Catalytic Properties for 2-chloro-2-propen- 1-ol and Ethylene Oligomerizations
Authors: Malinowski Jacek , Jacewicz Dagmara , Sikorski Artur , Urbaniak Mariusz , Rybiński Przemysław , Parnicka Patrycja , Zaleska-Medynska Adriana , Gawdzik Barbara , Drzeżdżon Joanna
Published: March 2021

The contemporary search for new catalysts for olefin oligomerization and polymerization is based on the study of coordinating compounds and/or organometallic compounds as post-metallocene catalysts. However known catalysts are suffered by many flaws, among others unsatisfactory activity, requirement of high pressure or instability at high temperatures. In this paper, we present a new catalyst i.e. the crystalline complex compound possesing high catalytic activity in the oligomerization of olefins, such as 2-chloro-2-propen-1-ol and ethylene under very mild conditions (room temperature, 0.12 bar for ethylene oligomerization, atmospheric pressure for 2-chloro-2-propen-1-ol oligomerization). New material - Cat-CrNP ( [nitrilotriacetato - 1,10–phenanthroline]chromium(III) tetrahydrate) has been obtained as crystalline form of the nitrilotriacetate complex compound of chromium(III) with 1,10-phenanthroline and characterized in terms of its crystal structure by the XRD method and by multi-analytical investigations towards its physicochemical propeties The yield of catalytic oligomerization over Cat-CrNP reached to 213.92 g ∙ mmol-1 ∙ h-1∙ bar-1 and 3232 g ∙ mmol-1 ∙ h-1 ∙ bar-1 for the 2-chloro-2-propen-1-ol and ethylene, respectively. Furthemore, the synthesis of Cat-CrNP is cheap, easy to perform and solvents used during preparation are environmentally friendly.
Efficiency and Kinetics of Assam Crude Oil Degradation by Pseudomonas Aeruginosa AKS1 and Bacillus Sp. AKS2
Authors: Chettri Bobby , Singha Ningombam Anjana , Singh Arvind Kumar
Published: March 2021

We report kinetics of Assam crude oil degradation by Pseudomonas aeruginosa AKS1 and Bacillus sp. AKS2, both isolated from Assam refinery sediments. The isolates exhibited appreciable degrees of hydrophobicity, emulsification index and biosurfactant production. Crude oil degradation efficiency of isolates was assessed in (1) liquid medium amended with 1% v/v crude oil and (2) microcosm sediments (125 mg crude oil/ 10 g sand). In liquid culture, the biodegradation rate (k) and half-life (t1/2) values were found to be 0.0383 day -1 and 18.09 days for P. aeruginosa AKS1, and 0.0204 day -1 and 33.97 days in case of Bacillus sp. AKS2. In microcosm sand sediments, the estimated biodegradation rate (k) and half-life (t 1/2) values were 0.0138 day -1 and 50 days for P. aeruginosa AKS1, and 0.0113 day -1 and 61.34 days in case of Bacillus sp. AKS2. The level of nutrient treatment in microcosm sand sediment was 125 µg N & 62.5 µg P/g sediment in case of P. aeruginosa AKS1 and 375 µg N & 37.5 µg P/g sediment in case of Bacillus sp. AKS2. In microcosms without inorganic nutrients, biodegradation rate (k) and half-life (t1/2) values were found to be 0.0069 day -1 and 100 days for P. aeruginosa AKS1 and for Bacillus sp. AKS2, the respective values were found to be 0.0046 day -1 and 150.68 days. Our data provides important information for predictive hydrocarbon degradation in liquid medium and contaminated sediments.
Development and Pilot Test of a Physician-Focused Cancer Clinical Trials Communication Training Intervention
Authors: Eggly Susan , Manning Mark , Senft Nicole , Moore Tanina Foster , Albrecht Terrance L. , Penner Louis A. , Heath Elisabeth , Carducci Michael A. , Lansey Dina G. , Hamel Lauren M.
Published: March 2021

PurposeClinical trials are critical to advancing cancer treatments, yet their impact is hindered by low accrual rates, especially among minorities. One barrier is the quality of physician communication during clinical interactions in which trials are discussed. We describe the development and pilot test of a physician-focused, web-based training module designed as an intervention to improve physician communication related to discussing clinical trials in a diverse cancer patient population. The purpose of the pilot test was to assess acceptability and preliminary effectiveness in improving physician beliefs, attitudes, knowledge, and comfort related to discussing cancer clinical trials with patients and families in a diverse patient population.MethodA team of researchers, clinicians, and community members developed the training module based on current communication research and analysis of an archive of video-recorded patient-oncologist interactions. The module included a brief didactic video explaining patient-centered communication strategies for discussing trials, and re-enactments of selected video clips from the archive to provide illustrations and guide opportunities for reflection. For the pilot test, the module was provided to physician participants in the Partnering Around Cancer Clinical Trials (PACCT) trial at two NCI-designated comprehensive cancer centers. Pre-post measures included assessments of change in beliefs, behavioral attitudes, knowledge and comfort related to discussing trials; measures also assessed evaluations of the module. ResultsNineteen physicians participated in the pilot test of the module. Most were very experienced in discussing trials. Pre-post assessments indicated mixed findings about beliefs, marginal improvement in attitudes, and a significant improvement in knowledge, but no change in comfort discussing trials. Feedback on the module was favorable. ConclusionsThis pilot test of a stakeholder-developed physician communication training module demonstrated its acceptability and effectiveness, even in this highly-experienced physician sample. Future research is needed to determine its effectiveness on communication in clinical settings. Trial Registration Number NCT02906241
An Investigation Into the Mechanism of Li Chong Pill for Treating Endometriosis Based on Network Pharmacology and Molecular Docking Verification
Authors: Liu Shao-Xuan , Han Feng-Juan , Zhang Chun-Lan , Shen Ying , Li Jia , Fu Yang , Guo Ying
Published: March 2021

Background and objective: Li Chong Wan (Li Chong pill, LCP) origin from Yi Xue Zhong Zhong Can Xi Lu, (Records of Chinese Medicine with Reference to Western Medicine), widely used in the treatment of endometriosis (EM) in China. The purpose of this study is to investigate the intrinsic mechanisms of LCP against EM and to provide new evidence for its clinical application.Methods: Chemical compounds of LCP were screened and evaluated via retrieving public databases and literature. We also acquired their putative targets and obtained EM-related targets. The above-mentioned data were visualized as a component-target network. In addition, we use Cytoscape3.8.0 to build a protein-protein interaction network and identified hub genes and key active ingredients. Furthermore, through GO and KEGG pathway analyses, which were actualized by R3.6.1 (based on clusterProfiler, org.Hs.eg.Db, and pathview package), we obtained effective signaling pathways and biological functions. Molecular docking was used to verify binding activity between compounds and the key targets at last.Results: Finally, a total of 122 possible active targets and 47 components were screened. Identify the core network and screen out 10 main targets; GO and KEGG enrichment analysis revealed that LCP may have functions of anti-inflammatory, anti-angiogenesis, inhibition of cell proliferation, regulation of hormone secretion, etc. The effect of LCP on EM might be achieved by PI3K/Akt signaling pathway, HIF-1 signaling pathway, estrogen signaling pathway, and VEGF signaling pathway, etc. Finally, molecular docking results demonstrated that 14 components were exhibited good binding property to the key targets of EM.Conclusion: This research ocularly demonstrated the multi-component, multi-target, and multi-channel pharmacological effects for LCP in the treatments of EM and provides evidence for further clinical research and verification of the mechanism.
Bifurcation Analysis of a Railway Wheelset With Nonlinear Wheel-rail Contact
Authors: Guo Jinying , Shi Huailong , Luo Ren , Zeng Jing
Published: March 2021

Stability is a key factor for the operation safety of railway vehicles, while current work employs linearized and simplified wheel/rail contact to study the bifurcation mechanism and assess the stability. To study the stability and bifurcation characters under real nonlinear wheel/rail contact, a fully parameterized nonlinear railway vehicle wheelset model is built. In modeling, the geometry nonlinearities of wheel and rail profiles come from field measurements, including the rolling radius, contact angle, and curvatures, etc. Firstly, four flange force models and their effects on the stability bifurcations are compared. It shows that an exponent fitting is more proper than a quintic polynomial one to simulate the flange, and works well without changing the Hopf bifurcation type. Then the effects of each term of the nonlinear geometry of wheel/rail contact on the Hopf bifurcation and Limit Circle bifurcation are discussed. Both the linear term and nonlinear term of rolling radius have a significant influence on Hopf bifurcation and Limit Point of Circle (LPC) bifurcation. The linear critical speed (Hopf bifurcation point) and the nonlinear critical speed (LPC bifurcation point) changes times while within the calculated range of the linear term of the rolling radius. Its nonlinear term changes the bifurcation type and the nonlinear critical speed almost by half. The linear term of contact angle, the radius of curvature of wheel, and rail profile should be taken into consideration since they can change both the bifurcation point and type, while the cubic term can be ignored. Furtherly, the field measured wheel profiles for several running mileages are employed to examine the real geometry nonlinearities and the according Hopf bifurcation behavior. The result shows that a larger suspension stiffness would increase the running stability under wheel wear.
Thiacloprid + Deltamethrin Against the Cotton Aphid and the Parasitoid Wasp Aphidius Colemani: From Lethal to Sublethal Population Effects
Authors: Majidpour Marzieh , Maroofpour Nariman , Ghane-Jahromi Mojtaba , Guedes Raul Narciso C.
Published: March 2021

The side effects of insecticides on non-target species are important to secure the intended effectiveness of pest management programs. The cotton aphid Aphis gossypii is a frequent problem in industrial greenhouse cultivation, and insecticide and parasitoids are often used for crop protection. Among insecticides, mixtures are playing increasing roles in pest management in greenhouse production system, as well as parasitoid use. The insecticide mixture thiacloprid + deltamethrin and the parasitoid wasp Aphidius colemani are the main agents used against the cotton aphid and are the focus of this study. Here, we report the effects of the thiacloprid + deltamethrin on A. gossypii and Aphidius colemani. The sublethal concentrations 2.80 mg ai/l (LC10) and 7.28 mg ai/l (LC30) compromised the demographic parameters of the aphid progeny and increased the development time at all juvenile stages. In addition, fecundity, longevity and population parameters (r, R0, and T) were significantly impaired by thiacloprid + deltamethrin, at both concentrations. The median lethal time estimate (LT50) for Aphidius colemani was 18.73 h; the parasitoid mortality was significant up to 24 h after application, but decreased afterwards. Regardless, the parasitoid life table parameters were also compromised by insecticide exposure, similarly to the parasitoid population growth and parasitism efficacy. These results demonstrate the effect of the insecticide mixture against A. gossypii, as well as the increased risk of its adverse impacts on the parasitoid Aphidius colemani, which signals against their simultaneous application to control this pest species.
Effect of In Situ Grown BNNTs and Preparation Temperature on Mechanical Behavior of SiC/SiC Minicomposites
Authors: Xu Shenwei , Pi Huilong , Wu Pengfei , Shi Yuan , Yang Haitang , Li Longbiao , Huang Xiaozhong
Published: March 2021

In this paper, effect of in situ grown boron nitride nanotubes (BNNTs) and preparation temperature on mechanical behavior of PIP (Precursor Infiltration and Pyrolysis) SiC/SiC minicomposites under monotonic and compliance tensile is investigated. In situ BNNTs are grown on the surface of SiC fibers using ball milling – annealing process. Composite elastic modulus, tensile strength, fracture strain, tangent modulus, and loading/unloading inverse tangent modulus (ITM) are obtained and adopted to characterize the mechanical properties of the composites. Microstructures of in situ grown BNNTs and tensile fracture surfaces are observed under scanning electronic microscopic (SEM). For SiC/SiC minicomposites with BNNTs, the elastic modulus, tensile strength, and fracture strain are all lower than those of SiC/SiC minicomposites without BNNTs, mainly due to high preparation temperature and the oxidation of the PyC interphase during the annealing process. Tensile stress-strain curves of SiC/SiC minicomposites with and without BNNTs are predicted using the developed micromechanical constitutive model. The predicted results agreed with experimental data. This work will provide guidance for predicting the service life of SiCf/SiC composite materials and may enable these materials to become a backbone for thermal structure systems in aerospace applications.
Formation of BaF2 Microcrystals as Superhydrophobic Materials via a Hydrothermal Method
Authors: Ma Jinxiu , Ou Gaoyu , Li Taohai , Li Feng
Published: March 2021

Controllable BaF2 microcrystals with super-hydrophobic property have been successfully synthesized via a facile hydrothermal process. XRD, SEM and CA are used to study the structure, morphology and the hydrophobic properties of the BaF2 materials. The effects of reaction time, surfactants and pH are also detailed investigated in order to get a series of accurate reaction conditions for the preparation of BaF2 material. The results show that uniform BaF2 tetragonal phase structure was fabricated when the reaction temperature was controlled at 180 oC for 24 h. In addition, the BaF2 materials showed excellent super-hydrophobic properties. The results about the influence of time and substrates exhibit that the sample can maintain the stable super-hydrophobic property for over 10 days. As a promising super hydrophobic materials, the studies of BaF2 reported in this paper is quite practical and it has a certain guiding meaning for the future study about super hydrophobic materials.
Assessment of rotary drum and aerated in-vessel for composting of garden waste
Authors: Mishra Sandeep , Yadav Kunwar D
Published: March 2021

For in-vessel composting of garden waste, the selection of reactor is an important factor for efficient degradation. The present study evaluates working performance of rotary drum reactor (RDR) and aerated in-vessel (AIV) for composting of garden waste. 100 kg garden waste was mixed with 10 kg cow-dung slurry and 5 kg compost and feed into both the reactors for 45 days composting period. The reactors vary in their system configuration, shape and orientation, blade design, rate of aeration, odour control, leachate production and energy requirements. Rotary drum was rotated daily six times in clockwise and anti-clockwise direction and AIV was rotated daily for 3–5 minutes using motor. Rise in temperature started within 24 hours of composting and reached 65°C and 59°C on second day itself and thermophilic phase continued for 7 and 5 days for RDR and AIV respectively. Moisture content reduction after composting period was 15.25 and 18.45 %, C/N ratio was 16.14 and 13.33, TVS reduction was 23.74 and 29.78 % and CO2 evolution rate was 6.18 and 4.14 mg/g VS/day in RDR and AIV respectively. Reduction of hemicellulose, cellulose, and lignin was more in AIV. The percentage reduction of acid insoluble lignin was 36.10 and 29.01 % and the percentage reduction of acid soluble lignin was 48.85 and 43.3% in in AIV and RDR respectively after 45 days. AIV gave better performance for composting of garden waste.
Extracellular Pyomelanin Pigment Production, Purification and Characterization with Streptomyces griseus MPPS2
Authors: BAYRAM Sinan
Published: March 2021

Melanins are natural pigments widely distributed in nature from bacteria to humans. These complex, negatively charged, amorphous, high molecular mass natural biopolymers have many different bioactive properties such as antimicrobial, antiviral, antioxidant, liver protective effects etc. In this study, some chemical and physical properties of the extracellular pyomelanin pigment purified from Streptomyces griseus MPPS2 was investigated via XRD (X-Ray diffraction), FT-IR (Fourier transform infra-red) and 1H NMR (Nuclear magnetic resonance). Additionally, the melanin pigment-producing Streptomyces griseus MPPS2 strain was identified at species level by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/TOF MS) and 16S rDNA sequence analysis. 16S rDNA sequence analysis result was deposited in NCBI under accession number MT825616.
Hydrolyzed FB1 (aminopentol) detection on urine of HPV positive Mexican women: A preliminary study
Authors: Ramírez-Cisneros M. Ángeles , Rivera Vladimir , Rios Maria Yolanda , Vargas-De-León Cruz , Dávila Sonia , Peralta Raúl
Published: March 2021

Human Papillomavirus (HPV) infection is the most common sexually transmitted disease in humans. About 200 HPV types have been described and classified into high and low oncogenic risk for its ability to transform the cell. Some main risk factors for HPV infection are multiple sexual partners, multiparity and immunosuppression. However, these factors can not completely explain the HPV prevalence in different world regions. Mexico has a high global burden, being important to determine other external biological factors implicated. The infection is mediated by surface receptors of basal stratum cells that bind to the viral capsid entering the cell by endocytosis. Some cell membrane components such as sphingolipids have a role in structure and membrane permeability. Besides, fumonisins are micotoxins structurally very similar to sphingolipids, fumonisin B1 (FB1) is the most abundant and most similar to some sphingolipids such ceramide. Fumonisins are produced by Fusarium fungus, widely distributed in maize, the main component of Mexican diet. Thus, it is possible that FB1 contamination be a factor to permeabilize the membrane expediting the HPV infection. In this preliminary study, we postulated that mechanism of HPV infection is mediated by contamination with FB1, hence, FB1 could be higher in women HPV positive. Urine samples from patients with HPV infection and healthy woman were analyzed by UPLC-MS, hydrolyzed FB1 was found only in the infected women, in contrast, in HPV negative women was not detected. Additional studies are needed to support the hypothesis of contamination with FB1 as biological risk factor for HPV infection.
Genetic Diversity and Population Structure Analysis of Chinese Wild Grape Using Simple Sequence Repeat Markers
Authors: Li Beibei , Fan Xiucai , Zhang Ying , Liu Chonghuai , Jiang Jianfu
Published: March 2021

Chinese wild Vitis is a useful gene source for resistance to biotic and abiotic stresses, although there is little research on its genetic diversity and structure. In this study, nine simple sequence repeat (SSR) markers were used to assess the genetic diversity and genetic structure among 100 Vitis materials. These materials included 77 indigenous accessions representing 23 of 38 wild Vitis species/cultivars in China, 18 V. vinifera cultivars, and the five North American species V. aestivalis, V. girdiana, V. monticola, V. acerifolia, and V. riparia. The SSR loci used in this study for establishing an international database (Vitis International Variety Catalogue) revealed a total of 186 alleles in 100 Vitis accessions. The mean values for the gene diversity (GD) and polymorphism information content (PIC) per locus were 0.91 and 0.90, respectively, which indicates that the discriminatory power of the markers is high. Based on the genetic distance data, the 100 Vitis accessions were divided into five primary clusters by cluster analysis, and five populations by structure analysis; these results indicate these Chinese wild grapes were more genetically close to European grapes than to North American species. In addition, the clustering patterns of most accessions correlated with the geographic distribution. An analysis of molecular variance (AMOVA) revealed that 3.28%, 3.27%, and 93.46% of the variance occurred between populations, between individuals within populations, and between individuals within the entire population, respectively. In addition, we identified three previously undescribed accessions (Wuzhi-1, MZL-5, and MZL-6) by cluster analysis. Our results reveal a high level of genetic diversity and variability in Vitis from China, which will be helpful in the use of genetic resources in future breeding programs. In addition, our study demonstrates that SSR markers are highly suitable for further genetic diversity analyses of Chinese wild grapes.
Frozen Section Diagnosis: Accuracy and Errors; with Emphasis on Reasons for Discordance
Authors: Gidwani Roopam Kishore , Goswami Falguni Jay , Mehta Arpan , Shah Nirali V , Prajapati Shobhana Ashok , Shah Manisha M
Published: March 2021

Background: Frozen section is a multistep process involving surgical resection, intraoperative preparation of slides and their microscopic examination.  It is important to   assess concordant, discordant and deferred diagnosis rates from intra-operative frozen section diagnosis with final diagnosis on paraffin section and to determine the reasons for discordance. An integral part of quality assurance in surgical pathology entails the correlation of intra-operative frozen section diagnosis with final diagnosis on permanent section. 

Methods:  A retrospective analysis of 117 cases of frozen section biopsy was carried out which were reported in the Histopathology department between July 2007 to June 2012.  The correlation between the frozen section diagnosis with final histological diagnosis was performed in order to check the accuracy of the technique.  The number and type of discrepancies were compared, causes for the discrepancies were analyzed in order to decrease the avoidable errors and improve on the frozen section diagnoses.  

Results:  The overall accuracy of frozen section diagnoses over 5years was 90.60% with false positive rate of 0.85%, false negative rate of 6.84% and 1.71% of deferred diagnosis. Sensitivity was 87.69% and Specificity was 98%.  The discrepancies were mainly due to the interpretation error, sampling error and technical artefacts.

Conclusions:  Gross inspection, sampling by pathologist, frozen section complemented with cytological and histological review and cooperation between consultants can avoid certain limitations and provide rapid, reliable, cost effective information necessary for optimum patient care.
Metastatic Breast Carcinoma to The Uterine Cervix - An Unusual Presentation
Authors: Varghese Maymol P , Raju Sreeja , MC Savithri , Augustine Joy , Varghese Mathew
Published: March 2021

Uterine cervix involvement as a site of metastasis from a distant primary tumor is rare. Metastasis from breast carcinoma in a patient undergoing treatment is even rarer.  The present case report is of a 47-year-old lady with history of carcinoma breast on treatment and who was referred to our hospital with complaints of lower limb oedema, low backache and postmenopausal whitish discharge per vaginum. Per vaginal examination revealed a lesion arising in the cervix extending up to the anterior vaginal wall suggestive of a clinical diagnosis of carcinoma cervix. Subsequent biopsy from the lesion showed malignant cells arranged in Indian file pattern and focal alveolar pattern, hinting at a diagnosis of Invasive lobular carcinoma metastasis.  The neoplasm was positive for ER, PR and GATA-3 and negative for Her2/neu and E-cadherin confirming our diagnosis. Although rare, the poor outcome in such patients makes it even more important for its identification and the need for them to undergo careful routine gynecologic examination.
A Rare Case of Mixed Ductal Neuroendocrine Tumor of the Pancreas
Authors: Viswanathan Vidya , Kumar Harsh , Gore Charusheela , Kurhade Shrikant , Khan Rumaanah
Published: March 2021

Collision tumors are tumors that have at least two types of tumors in the same anatomical site with no area of mixing within the transition zone. In 2010 WHO classification of neuroendocrine tumors consists of an adenocarcinoma component and a neuroendocrine carcinoma component in which each of the components accounts for 30% of the tumor. Such tumors are defined as mixed adenoneuroendocrine carcinomas. Occurrence of exocrine and endocrine tumors of the pancreas is extremely rare. The aim of our study was to describe a case in a 60 years old male who was diagnosed with this rare tumor. Gross, microscopic features and immunohistochemistry were used to diagnose this rare condition. Immunohistochemistry markers such as synaptophysin, chromogranin, EMA and Pan CK were used to come to a definitive diagnosis. Synaptophysin and chromogranin were found to be positive in the neuroendocrine component. EMA and Pan CK were found to be positive in the ductal component. Hence a diagnosis of mixed ductal neuroendocrine tumour (collision tumor) was made.
Atypical Cervical Stromal Cells Masquerading as Malignancy
Authors: Kurekar Shraddha Avinash , Chaudhari Jayashri Popat , Shenoy Asha Sharad , Chaturvedi Rachana Ajay
Published: March 2021

Atypical stromal cells (ASCs) of the female genital tract are uncommon and found in various polypoid lesions of the vulva, vagina, cervix and endometrium. Although they are benign; they can be misinterpreted as a malignant. Hence it is important for a pathologist to identify the ASCs in the specimens or biopsies of lower Female genital tract and avoid over diagnosis as a malignancy. We present a case of atypical cervical stromal cells in a 45-year-old female. On microscopy, Atypical stromal cells were stellate, enlarged in size, with moderate to severely atypical hyperchromatic, multilobulated nuclei without any mitoses. Their chromatin was dense often with prominent nucleoli. This report highlights the significance of awareness about the occurrence of these cells in the female reproductive tract.
A Theoretical Antioxidant Mechanism for Cytoprotective Effect of p-AcetamideSalicylate Derivatives against Free Radical Initiator AAPH in Human Erythrocytes
Authors: Barros Valéria , Pereira Glaécia , Ota Sirlene , Melo Fernanda , de Jesus Ana Carolina , Lima Anderson , da Silva Albérico , Borges Rosivaldo
Published: March 2021

The molecular mechanism of cytoprotective effect on human erythrocytes of aminophenol and salicylates associated derivatives was related to their antioxidant capacity. The oxidative hemolysis induced by water-soluble free-radical initiator 2,2’-azobis-(2-amidine-propane)-dihydrochloride (AAPH) was inhibited by drug candidates named benzaminophen (BZL), salicytamide or 5-acetamide-salicylic acid (ASL), and salibenzamide or 5-benzamide-salicylic acid (BSL) when compared to their parents salicylic acid (SAC) and acetaminophen (ACP). Trolox (TLX) was the most powerful compound and used as positive control. BZL showed a potent effect followed by ACP > BSL > ASL. SAC did not show protective effect in any evaluated concentrations. These results are in accordance with the molecular mechanism by using theoretical calculation of single electron transfers (SET), hydrogen atom transfers (HAT), and sequential proton loss electron transfer (SPLET) by means of DFT/B3LYP/6-31++G(d,p) level of theory. [1,5] Hydrogen shift between carboxyl and phenol moieties and electronic properties related to pKa and other physicalchemical properties can be involved. The molecular association approach provides protective compounds more effective than SAC.
Introducción a la cardiología de psitaciformes
Authors: Sciabarrasi Bagilet Antonio Alejandro , Fajardo Camps Jorge
Published: March 2021

Para la detección de enfermedades cardíacas en psitaciformes, existen muchos factores que dificultan su diagnóstico, sumado a que generalmente los signos de un loro cardiópata no son específicos y el examen físico del sistema cardiovascular es limitado. Los métodos diagnósticos más frecuentes como la radiología, el electrocardiograma o la ecocardiografía pueden complicarse por: el tamaño reducido de algunas especies, las altas frecuencias cardíacas y los escasos valores de referencia. A pesar de ello, es necesario realizar estas pruebas para obtener un diagnóstico ajustado de la patología cardíaca. El presente trabajo tiene como objetivo compilar la información existente sobre la cardiología en psitaciformes mediante sus estudios complementarios para ampliar y facilitar la práctica clínica con estas importantes herramientas diagnósticas y así familiarizar al profesional veterinario en el estudio de la fisiología y patologías del sistema cardiovascular en estas aves.
DIABETIC NEUROPATHIC PAIN
Authors: Rachmantoko Reza , Afif Zamroni , Rahmawati Dessika , Rakhmatiar Rodhiyan , Nandar Kurniawan Shahdevi
Published: March 2021

Diabetic Neuropathy is the most common complication from diabetes, which experienced in almost 90% diabetes patient. Evenly pain is one of the most common symptoms of diabetic neuropathic, but the pathophysiology mechanism of pain is not clearly known. The hyptosesis of toxicity of hyperglycemia on development of pain complication has been widely accepted globally, but there is other proposed hypothesis. Basic concept in management of painful diabetic neuropathic is exclusion of the other cause of painful peripheral neuropathy, improving glycemic control for prophylaxis therapy and medication use for alleviating pain. The first choice drug of therapy for alleviating pain are anticonvulsant, like pregabalin and gabapentin, and antidepressant, mainly that work on inhibiting serotonine and noradrenaline reuptake. In conclusion, the better understanding of painful diabetic neuropathic underlying mechanism can help to find a better management that improving the guideline quality in optimalizing pain control.
Migraine as a Common Extra-Intestinal Presentation of Celiac Disease
Authors:   Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore Department of Emergency Medicine, Rome, Italy, Gabrielli Maurizio , Ojetti Veronica , Candelli Marcello , Santarelli Luca , Gasbarrini Antonio , Franceschi Francesco
Published: March 2021

Celiac disease (CD) is a common gluten-related enteropathy that presents several extra-intestinal manifestations. Migraine is globally recognized as one of the most diffuse primary headaches. The present paper aims to review the current evidence on the possible association between CD and migraine. Both adults and children having CD exhibit a high prevalence of migraine. However, screening for CD in an unselected population of migraineurs demonstrated contrasting results. Brain imaging may reveal cerebral calcifications and/or white matter abnormalities in a small number of patients having migraine with underlying CD. Limited data are available on the effects of gluten-free diet (GDF) on migraine in the patients affected by CD, suggesting the efficacy of such intervention on the migraine symptoms in both adults and children. Nonetheless, this inference requires verification with high-quality trials conducted with larger sample sizes and longer follow-up periods.
COVID-19 and Cybersecurity: Finally, an Opportunity to Disrupt?
Authors: Ferreira Ana , Cruz-Correia Ricardo
Published: March 2021

COVID-19 has challenged cybersecurity to meet the ultimate need of guaranteeing the privacy and security of human beings. Although personal and sensitive health data are needed to better understand, detect, and control the disease, many related cybersecurity challenges and vulnerabilities require further analysis and proper discussion. The aims of this viewpoint are to explore the consequences of COVID-19 on cybersecurity and health care as well as to foster awareness regarding the need for a change in paradigm on how cybersecurity is approached. Education and information technology literacy are important when they are suitably provided; however, they are certainly not a complete solution. Disruption needs to occur at the core of human-device interactions. Building trust, providing novel means to interact with technology (eg, digital humans), and supporting people—the most important cybersecurity asset—are only some of the recommendations for a more human and resilient approach to cybersecurity, during or after the pandemic.
Machine Learning for Mental Health in Social Media: Bibliometric Study
Authors: Kim Jina , Lee Daeun , Park Eunil
Published: March 2021

Background

Social media platforms provide an easily accessible and time-saving communication approach for individuals with mental disorders compared to face-to-face meetings with medical providers. Recently, machine learning (ML)-based mental health exploration using large-scale social media data has attracted significant attention.

Objective

We aimed to provide a bibliometric analysis and discussion on research trends of ML for mental health in social media.

Methods

Publications addressing social media and ML in the field of mental health were retrieved from the Scopus and Web of Science databases. We analyzed the publication distribution to measure productivity on sources, countries, institutions, authors, and research subjects, and visualized the trends in this field using a keyword co-occurrence network. The research methodologies of previous studies with high citations are also thoroughly described.

Results

We obtained a total of 565 relevant papers published from 2015 to 2020. In the last 5 years, the number of publications has demonstrated continuous growth with Lecture Notes in Computer Science and Journal of Medical Internet Research as the two most productive sources based on Scopus and Web of Science records. In addition, notable methodological approaches with data resources presented in high-ranking publications were investigated.

Conclusions

The results of this study highlight continuous growth in this research area. Moreover, we retrieved three main discussion points from a comprehensive overview of highly cited publications that provide new in-depth directions for both researchers and practitioners.
Urbane Diakonie
Authors: Sigrist Christoph
Published: March 2021

Christoph Sigrist stellt in seinem Beitrag «Urbane Diakonie» die Eckwerte eines neuen diakoniewissenschaftlichen Projekts dar: Ausgehend von der Beobachtung, wonach «in städtischen Quartieren aufgrund der je eigenen Bevölkerungsstruktur, der Gentrifizierung und einer voranschreitenden nachbarschaftlichen Distanzierung zunehmend menschliche Nöte und Bedürfnisse bestehen, die bislang noch nicht ausreichend in den Fokus der Öffentlichkeit geraten sind», soll das Projekt «Urbane Diakonie» in «Stadtquartieren soziale Prozesse initiieren, begleiten und unterstützen, in denen Bewohnerinnen und Bewohner ermutigt werden, sich […] in den sozialen Nahraum, das Quartier, einzubringen und diesen Lebensraum als solidaritätsstiftenden Begegnungsraum zu revitalisieren.» Das Projekt will Kirchgemeinden, aber auch diakonischen Stiftunge und Werken, «Instrumente und Ideen in die Hand [geben], wie sie [die] Rolle als ‹Gemeinschaftsstifterinnen› in enger Zusammenarbeit mit öffentlichen und zivilgesellschaftlichen Institutionen sowie weiteren nahräumlichen Ressourcen ausgestalten können». Besonders im Fokus stehen Menschen im dritten und vierten Lebensalter.Sigrist geht sodann auf die bestehenden Instrumente des Projekts ein: Mit einer Projektwebseite www.urbanediakonie.ch besteht ein erstes Tool, um «die Solidarkultur in den Prozessen von Urbanität und Gentrifizierung zu fördern, zu stärken oder neu einzurichten». Weiter wurde ein Handbuch «Urbane Diakonie» erarbeitet, das Projektleitenden als Handreichung für die wissenschaftliche Einordnung ihrer Projekttätigkeit bietet. Schliesslich besteht ein Fundraisingkonzept, das es ermöglichen soll, neue Quellen für die städtischen diakonischen Projekte zu erschliessen.Im Zürcher Stadtteil Witikon, dem Stadtteil mit dem höchsten Anteil an über 65-jährigen Bewohnerinnen und Bewohnern, konnte bereits ein erstes Pilotprojekt «Urbane Diakonie» eingerichtet werden. Die örtliche Kirchgemeinde engagiert sich insbesondere darin, dass die älteren Menschen «in der engeren Nachbar­schaft und im Quartier Orte für Gemeinschaft, Beziehung und Austausch finden und zu selbstorganisiertem Handeln angeregt werden».Das Projekt wird getragen von einer eigenen Stiftung «Urbane Diakonie».
7. Deutsch-Japanische Kirchenkonsultation: Tokio, 22.-29. April 2016
Authors: Weber-Berg Christoph
Published: March 2021

Christoph Weber-Berg berichtet in seinem Beitrag von seinen Erfahrungen aus der Deutsch-Japanischen Kirchenkonsultation, die vom 22. bis 29. April 2016 in Tokio und Umgebung stattfand. Die Konsultation findet alle drei bis sechs Jahre statt, diesmal erstmals mit Schweizer Beteiligung. Sie stand unter dem Titel «Diakonie und Reformation».Der Austausch zwischen den der deutsch/schweizerischen Delegation mit den Gastgeberinnen und Gastgebern aus den protestantischen Kirchen Japans fand anhand von Empfängen, Konferenzen, Exkursionen und Gemeindebesuchen statt, über welche Weber-Berg chronologisch berichtet: so etwa über die Gemeindebesuche und die gehaltenen Gottesdienste in den protestantischen Kirchgemeinden vor Ort, über den Besuch sozialer Brennpunkte in Tokio und übe Ausflüge zu diakonischen Kinder- und Frauenheimen in der Umgebung. Weber-Berg hebt in seinem Bericht insbesondere die Exkursion in das von der Reaktorkatastrophe verseuchte Gebiet Fukushima hervor. In der zweitägigen Exkursion erlebt die Delegation das gewaltige Ausmass der ökologischen Katastrophe, das mannigfache soziale Auswirkungen nach sich zieht: massive Abwanderung, Entzug ökonomischer Grundlagen und Spannungen in vielen Familien, die zwischen Bleiben und Wegzug stehen. «Es ist unfassbar, was diese Katastrophe hier angerichtet hat. […] Unfassbar auch, was mit der geschändeten Natur geschieht.» Weber-Berg resümiert: «Mir ist nach diesem Tag klarer denn je: Atomkraft ist keine Option. Selbst wenn die Technik beherrschbar sein sollte: Der Mensch ist nicht beherrschbar. […] Die Hilflosigkeit im Umgang mit den Folgen dieser Katastrophe ist selbst in einer hoch entwickelten Industrienation wie Japan grenzenlos.» Die Delegation zeigte sich erfreut und dankbar über das grosse Engagement der Kirchen vor Ort, die gemeinsam mit vielen bürgerschaftlichen Initiativen «Teil der Bewegung [wurden], die den Menschen hier dabei helfen soll, die Folgen der Katastrophe zu bewältigen».Die Konsultation hat für Weber-Berg «die eine, weltweite Kirche für die Teilnehmenden erlebbar und erfahrbar werden lassen», was «auch die Wahrnehmung des eigenen Kircheseins» verändere. Er erachtete es als sehr lehrreich, anhand der Situation der japanischen protestantischen Kirchen zu erleben, wie «die Metamorphose von der Mehrheits- zur Minderheitskirche» geschafft werden kann, «ohne dabei dem Rückzugsreflex zu verfallen».