bluuebunny/crossref_metadata_2025 huggingface dataset:
Patient Reported Indicator Surveys (PaRIS): Methodological Considerations of a Field Trial in Slovenia
Authors: AMBROŽ Matija , KENDIR Candan , BOERMA Wienke , KLEMENC-KETIŠ Zalika
Published: December 2023

Introduction

Healthcare systems collect little information about the experiences and outcomes of care from the perspectives of patients. Patient Reported Indicator Surveys (PaRIS) is an OECD initiative to measure the outcomes and experiences of people living with chronic conditions, who are managed in primary care.

Objectives

To evaluate the feasibility of the methodology employed in the Field Trial of the PaRIS survey in Slovenia and propose adjustments to enhance sampling in the Main Survey.

Methods

In 2022, we conducted a cross-sectional observational study in 50 family medicine practices in Slovenia with a target of recruiting 70 patients per practice. We used the Slovenian version of the PaRIS questionnaires, and evaluated sampling and data collection.

Results

The sample contained 21 providers (42.0% response rate) and 454 patients (50.7% response rate). The provider sample did not differ from the population characteristics, while the patient sample differed significantly from the patient population. All providers completed the survey online, in 20.9±11.1 minutes and had 1.5±1.5 restarts. Most patients (74.9%) completed the survey online and needed 36.0±22.6 minutes, and the mean number of restarts was 1.4±2.2.

Conclusion

Based on the results, we recommend conducting a methodology test for quality assessment studies before initiating the main survey. Legal issues should be addressed and considered early when developing the methodology. It is also necessary to be aware of the feasibility of the study in practice, to avoid a low participation rate.
Analisis Optimalisasi dan Evaluasi Pelayanan Pada Mal Peyanan Publik Merdeka Kota Malang
Authors: Sekarsari Retno Wulan
Published: December 2023

Tujuan dilaksanakanya penelitian ini adalah agar dapat menganalisa optimalisasi dari Pelayanan Publik di Kota Malang. Peneliti menggunakan teori pelayanan publik dan mall pelayanan publik untuk mengevaluasi pelayanan yang ada. Metodologi yang digunakan adalah metode campuran yang terfokus untuk menganalisis dan evaluasi efektifitas pelayanan Mal Pelayanan Publik di Kota Malang dan optimalisasi dalam komunikasi publik Pemerintah Kota Malang terkait program yang ada di mall pelayanan Publik.Kata Kunci: Optimalisasi, Evaluasi, Pelayanan, Publik.
Model Hay System Dalam Penentuan Job Grading Untuk Peningkatan Kinerja Karyawan dan Performa Perusahaan
Authors: Pamungkas Puguh Wiji , Bagyo Yupono
Published: December 2023

Organisasi pemerintah termasuk perusahaan swasta sering menghadapi persoalan pada evaluasi kinerja karyawan atau sumber daya manusia (humas resources). Penelitian ini dilakukan untuk mengetahui penerapan model hay system dalam penentuan job grading berdasarkan penilaian jabatan di organisasi pelayanan kesehatan, Rumah Sakit Umum (RSU) Wajak Husada Malang, Jawa Timur. Dari penelitian yang dilakukan model hay system dalam penentuan job grading memiliki peran penting dalam pengklasifikasian jabatan dan pekerjaan pada jabatan tertentu. Selanjutnya membawa manfaat terhadap penggajian dan evaluasi kinerja karyawan. Job grading dapat meningkatkan kinerja sumber daya manusia (human resources) sehingga lebih optimal. Hal tersebut membawa dampak positif terhadap institusi pelayanan kesehatan RSU Wajak, dilihat dari bertambahnya jumlah kunjungan pasien, baik yang rawat inap maupun rawat jalan. Penelitian ini menggunakan model kualitatif deskriptif, dengan teknik pengumpulan data melalui observasi di lokasi penelitian, dan wawancara mendalam bersama para informan. Penelitian ini memiliki keterbatasan karena hanya dilakukan di satu rumah sakit saja, pada tahun 2022. Untuk itu diperlukan penelitian lebih lanjut di rumah sakit lain atau di institusi pemerintah.
Pengaruh Pelatihan dan Pengembangan Karir Terhadap Kinerja Karyawan pada PT. Sinar Dunia
Authors: Hamzah Akbar Mohammad , Resdiana Enza
Published: December 2023

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh secara parsial dan simultan pelatihan dan pengembangan karir terhadap kinerja karyawan pada PT. Sinar Dunia. Penelitian ini menggunakan pendekatan asosiatif, yaitu penelitian yang dilakukan untuk mengetahui pengaruh atau hubungan antara variabel bebas dengan variabel terikat. Populasi dan sampel dalam penelitian ini adalah karyawan pada PT. Sinar Dunia yang berjumlah 60 orang. Teknik pengumpulan data menggunakan kuesioner sedangkan analisis data dengan analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa Secara parsial pelatihan tidak memiliki pengaruh yang signifikan terhadap kinerja karyawan. Secara parsial pengembangan karier memiliki pengaruh yang signifikan terhadap kinerja karyawan. Dan secara simultan pelatihan dan pengembangan karier memiliki pengaruh yang signifikan terhadap kinerja karyawan pada PT. Sinar Dunia.
PENGEMBANGAN MASYARAKAT MELALUI POTENSI LOKAL DALAM MEWUJUDKAN DESA MANDIRI
Authors: Hidayat Imam , Ayu Putri , Puspaningrum Irma Irawati
Published: December 2023

Abstrak

Setiap desa memiliki potensi yang dapat dimanfaatkan baik dari sumber daya alam, manusia maupun sosial. Umumnya Permasalahan yang ada di desa adalah rendahnya pendidikan menjadikan potensi tidak mampu termanfaatkan dengan baik, oleh karena itu perlu adanya Pengembangan masyarakat untuk meningkatkan kemampuan dan keterampilan masyarakat sehingga masyarakat dapat mandiri dalam membangun usaha dan mencari peluang. Pengembangan masyarakat sebagai salah satu upaya pemerintah desa dalam mewujudkan desa mandiri. Penilitian ini bertujuan untuk mengetahui bagaimana pengembangan masyarakat melalui potensi lokal dalam mewujudkan desa mandiri di desa Lobuk kecamatan Bluto kabupaten Sumenep. Pengembangan masyarakat sebagai suatu proses terorganisir untuk memperbaiki kehidupan masyarakat desa kearah yang lebih baik, dengan menggunakan 4 indikator, Penelitian ini menggunakan metode kualitatif deskriptif. Hasil penelitian menunjukkan bahwa pengembangan masyarakat mampu meningkatkan keterampilan masyarakat, pengembangan dilakukan oleh pemerintah desa melalui pemanfaatan 3 potensi besar desa yaitu potensi laut dengan cara menghasilkan beberapa produk olahan masyarakat, potensi kelompok masyarakat yaitu dengan memanfaatkan kelompok masyarakat melalui kegiatan pengembangan masyarakat dalam memberi pelatihan ataupun menerima pelatihan, memberikan edukasi maupun sosialisasi serta memanfaatkan kesenian sebagai daya tarik dan ciri khas desa melalui beberapa pertunjukan. Beberapa produk dari hasil pengembangan masyarakat Lobuk meliputi teri crispy, co’o crispy kerupuk ikan, petis ikan, stik udang, nuget rumput laut, cendol rumput laut dan stik rumput laut. 

 

Kata Kunci: Pengembangan masyarakat, potensi lokal, desa mandiri
Acrodermatitis enteropathica: case report in children with crohn’s disease
Authors: Florêncio Livia , Lange Eloana , Pereira Elizandra , Silva Mariana , Haddad Gabriela
Published: December 2023

OBJECTIVES: Acrodermatitis Enteropathica (AE) is a rare disease that can be transmitted by autosomal recessive inheritance, it can be related to parenteral nutrition without zinc, or it can be secondary to malabsorptive syndromes. Clinically, it is characterized by the triad of acral and periorificial dermatitis, alopecia and diarrhea, accompanied by growth restriction. The condition can be fatal if left untreated. METHODS: We describe the case of a child with AE and Crohns Disease (CD), with AE being a known complication, secondary to malabsorption caused by CD. RESULTS: Treatment for CD was started with systemic steroids, Azathioprine and Mesalazine, and local care with the diaper area. Oral zinc replacement was also started. The child showed significant clinical and dermatological improvement within a few weeks. CONCLUSIONS: The diagnosis of AE is made with serum zinc levels lower than 70 ug/dL. Treatment involves zinc supplementation, at a dose ranging from 1 to 3 mg/kg/day. In the case described, the zinc value was 65 ug/dL. In this case, we started replacement with 2mg/kg/day, with rapid clinical improvement. Zinc deficiency AE is a well-known complication of CD, secondary to malabsorption. In the case described, the cutaneous condition came after the intestinal condition, with the deficiency in the absorption of zinc being secondary to Crohns Disease, leading to a condition with extensive lesions, but with a quick response to the treatment and with an important improvement of the condition.
Reconstruction of the early ethnic history of the Yakut tribe "Jarkhan" on the basis of ethnonymy, oral tradition and totemic ideas
Authors: Vinokurov Aleksandr Danilovich
Published: December 2023

The article is devoted to the early history of the Yakut tribe "Jarkhan", which was one of the main ethnic components involved in the formation of the Vilyui group of Yakuts. Previously, historical and genealogical information was transmitted orally with help of historical legends. The end of the XIX – the middle of the XX centuries marks a qualitatively new period in the formation of the written tradition of the genealogy of the Yakut people associated with the painstaking source studies, collecting and research work of G.V. Ksenofontov, S.I. Bolo, A.A. Savvin, G.U. Ergis, etc. We have made an attempt to show the process of segmentation of the Jarkhan clans and the formation of new tribal groups by compiling a nomenclature of the generic composition. The study of the generic composition allows us to imagine the processes of movement and settlement of genera, renaming, merging and formation of new ones. The purpose and objectives of the research are to systematize and interpret the materials of the oral genealogical tradition, legends and archival documents. The methodological basis of the research is based on the basic principles of historical science - the principle of historicism and the principle of objectivity. The principle of historicism is important for conducting genealogical research, as it allows us to trace the segmentation of large tribal groups into small ones. General scientific and historical methods (historical-comparative, historical-typological, source analysis) were used as additional research methods. The novelty of the research lies in the systematization of the tribal composition and the introduction into scientific circulation of previously unpublished documents of the National Archive of the RS(Ya) revealing the tribal composition. Based on the studied material, it is concluded that oral historical traditions and pedigrees represented the central core in the structure of historical knowledge among the Yakuts. Conceptually, genealogical traditions were formed from real genealogy and unreal, which is basically a structure-forming fictional genealogy (within the boundaries of tribal communities). The result of the work performed is the preparation of the nomenclature of the Yakut generic composition. We also found that the Yakuts had common, group and individual totems. Along with this, the practice of changing the historical totem to a new one associated with a new habitat has been revealed.
INVESTIGATION OF MICRORNA LEVELS, THE EXPRESSION OF WHICH IS REGULATED BY THE ARYL HYDROCARBON RECEPTOR, IN NON-SMALL CELL LUNG CANCER
Authors:   Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Valembakhov I.S. , Biruikova O.D. , Kononchuk V.V. , Kalinina T.S. ,   Research Institute of Clinical and Experimental Lymphology — Branch of the ICG SB RAS, Novosibirsk,   Meshalkin National Medical Research Center, Novosibirsk
Published: December 2023

In this work, the expression profile of miRNAs regulated by the aryl-hydrocarboxylic receptor (AhR) among patients with NSCLC (lung adenocarcinoma and squamous cell carcinoma) was studied using PCR, and their relationship with clinicopathological parameters was studied. For microRNA-21, -93, -146a, -181a, and -342, theire xpression was found to be related to smoking status, PD-L1, tumor size, and the presence of metastases in patients with NSCLC.
BINARY ANTISENSE OLIGONUCLEOTIDES ACTIVATE DEGRADATION OF THE TARGETED MRNA IN KRAS-DEPENDENT MANNER IN K562 CELL LINE
Authors:   SCAMT Institute, ITMO University, Saint Petersburg, Drozd V.S. , Rybalko D.S. , Salimova A.A. , Kolpashchikov D.M. , Eldeeb A.A. ,   Chemistry Department, University of Central Florida, Orlando, USA,   Burnett School of Biomedical Sciences, University of Central Florida, Orlando, USA
Published: December 2023

Biomarker-dependent degradation of target gene mRNA in the K562 cell line induced by binary antisense oligonucleotides (BiASO) was demonstrated. When BiASO was integrated into the DNA system, a 12-fold increase in mRNA degradation in the presence of the biomarker was achieved. The new BiASO technology is characterized by simplicity of design and also opens the possibility of directly targeting the most vulnerable housekeeping genes in cancer therapy.
DETECTION OF TRANSCRIPTOMIC DIFFERENCES IN CELL POPULATIONS OF ADRENOCORTICAL CELLS IN NORMAL CONDITIONS AND IN CYP21A1 GENE MUTATIONS
Authors:   Moscow Institute of Physics and Technology, Dolgoprudny, Kaziakhmedova C.A. , Glazova O.V. , Volchkov P.Yu.
Published: December 2023

The adrenal glands are an important endocrine organ producing corticosteroids and catecholamines. Pathologies that lead to a decrease in the endogenous production of all or some of the adrenal hormones are often caused by mutations in the genes of proteins responsible for various stages of their synthesis. One of the most common disorders of this type is congenital adrenal dysfunction (CAD) caused by mutations in the CYP21A2 (Cyp21a1) gene. In the most severe cases, the course of this disease can lead to such life-threatening conditions as an adrenal crisis. Identification of differences in the transcriptional profile of adrenocortical cells in normal and pathological conditions will help to study the course of the disease at a deeper, molecular level, which is feasible due to the rapid development of omics technologies. The purpose of this research work is to determine significant differences in the cell populations of adrenocortical cells in wild-type mice and mice with mutations in the Cyp21a1 gene.
SPECIFIC HUMORAL IMMUNE RESPONSE IN SYRIAN HAMSTERS IMMUNIZED WITH PVAXRBD DNA VACCINE USING JET INJECTION
Authors:   State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Kisakova L.A. ,   Tyumen State University, Kisakov D.N. , Yakovlev V.A. , Tigeeva E.V. , Borgoyakova M.B. , Makarova K.P. , Rudometov A.P. , Karpenko L.I.
Published: December 2023

The research was made of the humoral response in Syrian hamsters after immunization with an experimental DNA vaccine pVAXrbd encoding the RBD of the S protein of the SARS-CoV-2 virus, introduced using a needleless injector. It was shown that the median titers of antibodies specific to RBD in the sera of immunized animals reached 1:55050, which confirms the formation of a virus-specific humoral immune response.
ORAL CANCER MICROBIOTA IN YOUNG ADULTS AND ITS SIGNIFICANCE IN DISEASE PROGNOSIS
Authors:   Cancer Research Institute, Tomsk National Research Medical Center, RAS, Kolegova E.S. , Kononova L.A. , Fedorova I.K. , Kulbakin D.E. , Zhalsanova I.Zh. , Sivtsev A.A. , Skryabin N.A. , Denisov E.V. ,   Siberian State Medical University, Tomsk,   Research Institute of Medical Genetics, Tomsk National Research Medical Center, RAS
Published: December 2023

This study demonstrates the features of oral squamous cell carcinoma microbiome profile in young adults (<45 years) and its association with disease progression.
TRANSCRIPTOME ALTERATIONS IN BONE MARROW CELLS OF BCG-IMMUNIZED MICE
Authors:   Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Kondratyeva L.G. , Kuzmich A.I. , Linge I.A. , Didych D.A. , Alekseenko I.V. ,   National Research Centre “Kurchatov Institute”, Moscow,   Central Tuberculosis Research Institute, Moscow
Published: December 2023

The effect of BCG vaccine is known to enhance resistance to another disease, and this effect is associated with the training of innate immune cells. In the framework of this work, the transcriptomes of bone marrow cells of BCG-treated mice were studied. The involvement of differentially expressed genes in multiple immune processes and signaling pathways was demonstrated.
OMICS FOLLOWED BY THE ISOLATION OF NEW BACTERIOLYTIC ENZYME AMI OF LYSOBACTER CAPSICI XL1, PROMISING FOR THE DESIGN OF NEW GENERATION ANTIMICROBIALS BASED ON IT
Authors:   Skryabin Institute of Biochemistry and Physiology of Microorganisms, Pushchino, Kudryakova I.V. , Afoshin A.S. , Tarlachkov S.V. , Leontyevskaya E.A. , Galemina I.E. , Zelenov D.V. , Leontyevskaya N.V. ,   Pushchino Branch of Russian Biotechnological University (BIOTECH University)
Published: December 2023

In this study, the gene of bacteriolytic enzyme Ami of L. capsici XL1 was identified using omics. The homologous expression system was developed based on L. capsici IAEN. As a result of purification from culture liquid of expression strain, bacteriolytic amidase Ami was obtained. The physicochemicals properties of Ami, including substrate specifity, was studied.
HETEROGENEITY OF GENETIC ETIOLOGIES AND METHODS FOR DETECTING SEX DIFFERENTIATION DISORDERS (SDD) IN NEWBORNS AND ADOLESCENTS
Authors:   National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Ministry of Healthcare of Russian Federation, Moscow, Pavlova N.S. , Tsabai P.N. , Batyrova Z.K. , Kumykova Z.Kh. , Bolshakova A.S. , Uvarova E.V. , Trofimov D.Yu.
Published: December 2023

Twenty-seven patients with sex differentiation disorders (SDD) were examined. Genetic etiology was revealed in 22 out of 27 patients (81.5 %). Karyotyping was the method of detection in 14.8 % of cases, PCR of the SRY gene in 3.7 % of cases, and full-exome sequencing in 63 % of cases.
DEVELOPMENT M13 BACTERIOPHAGE-BASED TARGETED HYBRID VECTORS FOR HUMAN GLIOBLASTOMA CELL SELECTIVE TRANSDUCTION
Authors:   Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Petrov G.O. , Mukhanov V.S. , Dymova M.A. ,   Novosibirsk State University
Published: December 2023

Bacteriophages, bacterial viruses, are currently being used as source of effective gene therapy tools for cancer. The aim of this study was to develop targeted hybrid vectors based on filamentous phage M13, capable of efficient and selective delivery of transgenes into U-87 MG human glioblastoma cells.
IDENTIFICATION OF THE FUNCTIONAL ROLE OF 5-HT7 -TRKB HETEROCOMPLEXES IN VITRO
Authors:   Novosibirsk State University, Samarina S.A. , Tsybko A.S. , Naumenko V.S. , Ilchibaeva T.V. ,   Institute of Cytology and Genetics SB RAS, Novosibirsk
Published: December 2023

Previously we have identified heterocomplexes between serotonin 5-HT7 receptor and tropomyosin-related receptor kinase B (TrkB), known as the main receptor for BDNF. Based on known data, we decided to study the 5-HT7 -TrkB complex functional role in vitro. According to data, TrkB activation by agonist is blocked when 5-HT7 is present in the cell, although that does not affect second messsenger’s functioning; while 5-HT7 agonist treatment in the presence of the receptor decreases TrkB phosphorylation level.
EXPRESSION OF COPPER METABOLISM GENES IN CAENORHABDITIS ELEGANS DURING THE LIFE CYCLE
Authors:   Peter the Great Saint Petersburg Polytechnic University, Samuseva P.D. ,   ITMO University, Saint Petersburg, Mekhova A.A.
Published: December 2023

In the nematodes C. elegans with a genetic defect in copper metabolism, the expression of genes of the copper transport system (CTS) during ontogeny was studied. In worms, the H828Q substitution in the CUA-1 protein (ortholog of the human Wilson ATPase) was shown to cause a significant delay in development and death at the early stages of ontogeny upon treatment with Ag1+. The significance of the sequence of turning on the activity of CTS genes in the development of nematodes is discussed.
THE ROLE OF TRFL PROTEINS IN THE REGULATION OF TELOMERE LENGTH MARCHANTIA POLYMORPHA
Authors:   Institute of Fundamental Medicine and Biology, Kazan Federal University, Sannikova A.V. , Sharipova M.R. , Shakirov E.V. , Valeeva L.R. ,   Department of Biological Sciences, College of Science, Marshall University, West Virginia, Huntington, USA
Published: December 2023

Telomeres are nucleoprotein structures, involved in protection of the physical ends of eukaryotic chromosomes. A decisive role in maintaining telomere stability is played by specific proteins telomere complex are TRF proteins. Here, we have shown the intraspecific variability of telomere length and the involvement of TRFL protein in telolere length maintanance in a liverwort M. polymorpha as a new model plant for telomere biology studies.
THE ROLE OF THE TRIM14 PROTEIN IN THE IMMUNE RESPONSE TO A BACTERIAL INFECTION CAUSED BY PSEUDOMONAS AERUGINOSA IN TRANSGENIC MICE
Authors:   National Research Centre “Kurchatov Institute”, Moscow, Stepanenko E.A. , Gerasimova T.P. , Bondareva N.E. , Sheremet A.B. , Fedina E.D. , Tikhomirov A.D. , Makarova I.V. , Zigangirova N.A. , Tarantul V.Z. , Nenasheva V.V. ,   Gamaleya National Research Center for Epidemiology and Microbiology, Moscow
Published: December 2023

The study of the molecular mechanisms of interaction between the innate immune system and the bacterial pathogen Pseudomonas aeruginosa may contribute to the development of new approaches to combat bacterial infections. In this work, we showed that overexpression of human TRIM14 led to a decrease in the survival rate of transgenic mice upon P. aeruginosa infection. At the same time, the amount of phosho-STAT3 (p-STAT3) protein in the nuclear fraction in the lungs of transgenic mice increased after infection.
THE EFFECT OF MDM2 UBIQUITIN LIGASE ON ENERGY METABOLISM ENZYMES IN CELL MODELS OF HUMAN NON-SMALL CELL LUNG CANCER
Authors:   Institute of Cytology RAS, Saint Petersburg, Fefilova E.A. , Shuvalov O.Yu.
Published: December 2023

The aim of this work was to evaluate the effect of the ubiquitin ligase MDM2 on the expression of a number of metabolic enzymes in cell models of non-small cell lung cancer.
SINGLE-CELL IMMUNE PROFILING OF BREAST CANCER PATIENTS UNDER CHEMOTHERAPY
Authors:   Cancer Research Institute, Tomsk National Research Medical Center RAS, Frolova A.A. , Patysheva M.R. , Fedorov A.A. , Vostrikova M.A. , Bragina O.D. , Korobeynikov V.Yu. , Gerashchenko T.S. , Cherdyntseva N.V. ,   Tomsk State University
Published: December 2023

The main method of TNBC systemic treatment is chemotherapy. In this work, the immune landscape of the blood of patients with TNBC was evaluated using single cell sequencing technology in the dynamics of neoadjuvant chemotherapy. It has been shown that under the influence of therapy, dynamic changes in the population composition occur, leading to the activation of the adaptive immune response.
Operation al-Aqsa Flood: A Rupture in the History of the Palestinian Resistance and Its Implications
Authors: Mercan Muhammed Hüseyin
Published: December 2023

This paper argues that the al-Aqsa Flood operation launched by the Izz ad-Din al-Qassam Brigades –the military wing of Hamas– on the morning of October 7 has led to a psychological and epistemological rupture in the Palestinian-Israeli conflict and Middle East politics as the operation marked a paradigm shift in the philosophy of the resistance. The infiltration of al-Qassam into the occupied territories by land, sea, and air was a clear sign of a change in the strategy of the resistance to continue the active struggle against the aggressive expansionism and aggression of the Zionist Israeli government. In this context, the study tries to frame Operation al-Aqsa Flood and analyze the dimensions of the rupture. Besides this, it will also outline the possible impact of the operation on global and regional politics, considering that the ongoing process will change the political balance in the Middle East.
Taurodontism in primary molars: A case report
Authors: Chaudhary Ankita , Sultan Amina , Juneja Akanksha
Published: December 2023

Taurodontism is a development disorder involving large pulp chambers with the furcal areas located closer to the root apex. The crowns of teeth associated with taurodontism appear normal and its distinguishing features are present below the cementoenamel junction. This makes the radiographic evaluation crucial for its diagnosis. Taurodontism is more commonly found in permanent teeth than in deciduous teeth. Taurodontism occurs mostly as a lone anomaly. Still, it is associated with certain syndromes including Down’s syndrome (Trisomy 21), Klinefelter’s syndrome, and a few medical conditions such as hypophosphatasia. From the perspective of endodontics, taurodontism demands greater efforts for root canal therapies than for a tooth with a normal pulp chamber. The reason is larger pulp chambers that pose obturation errors in the tooth and increase failure percentage. This paper discusses taurodontism associated with primary molars in a 4-year-old dental patient.
Soft-tissue paradigm: A review
Authors: Thakur Vivek Kumar , Chaudhary Dinesh Chander , Jayan B. , Jain Vipul , Mathur Prateek
Published: December 2023

Facial esthetics and balanced facial proportions are the expectations of the orthodontic patient. Promising and achieving the desired facial esthetic outcome, with functional harmony are the major orthodontic challenges. A detailed study of facial hard and soft-tissue structures is required for an orthodontist to evaluate, diagnose, and treat the chief complaints of an individual orthodontic patient. Orthodontic treatment has evolved from the angles paradigm to the soft-tissue paradigm. Evaluation in terms of facial esthetics requires a thorough understanding of the concept of the soft-tissue paradigm. This review article summarizes existing major facial esthetic parameters comprehensively and will also act as a guide for the detailed scientific evaluation of soft-tissue proportions in achieving treatment goals in orthodontics and dentofacial orthopedics.
Variations in morphology of permanent maxillary lateral incisors and its impact on oral hygiene and diseases
Authors: Srivastav Anukriti , Aggarwal Dipanshu , Jain Anshi
Published: December 2023

The permanent maxillary lateral incisors are of great importance from an aesthetic standpoint, as any variation in their shape can lead to an unfavorable visual appearance. Furthermore, morphological variations such as peg-shaped, barrel-shaped, shovel-shaped, and canine-shaped teeth can impact oral hygiene and lead to additional health problems. The etiology of these variations is multifactorial, including genetic, epigenetic, and environmental factors. This paper aims to provide a comprehensive overview of the most common morphological variations of the permanent lateral incisors, including their causes, associated dilemmas, treatment modalities, and the various health and hygiene issues associated with these diverse physical characteristics. By highlighting the potential health and hygiene issues associated with these variations, this paper aims to increase awareness among dental professionals and the general public about the importance of regular dental care and check-ups to maintain oral health and aesthetics. A comprehensive understanding of the causes, dilemmas, and treatment modalities of these morphological variations can aid dental professionals in providing effective and personalized care to their patients. In conclusion, the morphology of the permanent maxillary lateral incisors plays a critical role in dental aesthetics, hygiene, and health.
The relationship between sense of coherence and oral health-related quality of life among medical and dental students in India: A cross-sectional study
Authors: Ravi Amala G , Thomas Susan , Narayan Vivek
Published: December 2023

Objectives:

To assess the sense of coherence (SOC) and oral health-related quality of life (OHRQoL) and evaluate the relationship between the two parameters among medical and dental students.

Materials and Methods:

This cross-sectional online survey was conducted among 210 medical and dental students in the district of Kottayam in Kerala, India. A stratified random sampling technique based on the year of study was employed. The sample size was calculated based on a pilot study conducted among 20 medical and 20 dental students. Mann–Whitney U-test, Kruskal–Wallis test, and Spearman’s correlation test were used for statistical analysis.

Results:

The SOC and OHRQoL were higher among dental students than medical students. Those exposed to clinical postings presented with a higher SOC than the preclinical students. Furthermore, SOC was negatively correlated with the oral health impact among the clinical category of students (P < 0.05).

Conclusion:

Health is dependent on the individual and other physical, biological, and psychosocial factors. The concept of sense of coherence (SOC) is a psychosocial determinant of oral health in adults. A strong association between SOC and oral health-related quality of life has been established. In this study, OHRQoL was associated with the SOC among medical and dental students. Clinical category of students expressed a high SOC and better OHRQoL. Although the clinical category of students asserted a better quality of life, their stress level needs to be minimized. Health promotion and prevention of psychosocial symptoms should be included in the medical and dental curriculum.
Sobrevivencia y respuestas fisiológicas de corales expuestos a elevada turbidez en el arrecife Varadero, Caribe colombiano
Authors: López-Londoño Tomás , Gómez-Campo Kelly , Galindo-Martínez Claudia T. , González-Guerrero Luis A. , Roitman Sofia , Pollock F. Joseph , Pizarro Valeria , López-Victoria Mateo , Medina Mónica , Iglesias-Prieto Roberto
Published: December 2023

El deterioro de las propiedades ópticas del agua, o aumento de turbidez, debido a perturbaciones antropogénicas es un fenómenogeneralizado en zonas costeras. Los efectos sobre el ambiente lumínico submarino y la fisiología de corales simbióticos, quedependen principalmente de la luz para sobrevivir y mantener elevada calcificación, han sido poco explorados. En este estudiose describen los efectos de la pluma del Canal del Dique sobre el ambiente lumínico, sobrevivencia y fisiología de corales en el arrecifeVaradero. Se realizó un trasplante recíproco con fragmentos de Orbicella faveolata entre una zona somera en Varadero (3.5 m) y un sitio contrastante con aguas más claras a mayor profundidad (12 m) con intensidad de luz comparable. La columna de agua en Varadero se  encontró fuertemente estratificada, favoreciendo el aislamiento del arrecife de la pluma. Corales trasplantados a Varadero mostraron mayor sobrevivencia posiblemente debido a reducción de estrés lumínico y mayor heterotrofía. Su fisiología indicó aclimatación a poca luz y limitado potencial autotrófico, evidenciando un riesgo para la sobrevivencia de corales a mayor profundidad. Los resultados indican que un mayor deterioro de las propiedades ópticas del agua en la bahía de Cartagena por perturbaciones antropogénicas en la cuenca del río Magdalena y en la zona costera pone en riesgo la prevalencia del arrecife Varadero.
Primer registro del pez globo Chilomycterus spinosus (familia Diodontidae) en el Caribe colombiano
Authors: Acosta Chaparro Andres Felipe , Navas Camacho Raúl , Polanco Fernández Andrea
Published: December 2023

Se registra por primera vez en el Caribe colombiano el pez globo Chilomycterus spinosus correspondiente a la familia Diodontidae. Un individuo de esta especie fue avistado en agosto de 2022 en la zona de Bahía Portete a una profundidad de 1.5 m. Se reporta una variación en el rango de profundidad de esta especie, a zonas más someras.
Assessment of the state of fixed assets of enterprises and organizations in the Arctic zone of the Russian Federation as a factor determining its sustainable development
Authors: Noeva E. E.
Published: December 2023

The analysis of the state of fixed assets is important for determining the production capabilities of the organization and strategic prospects of its development. The value of fixed assets determines the production capacity of the company, timely renewal of fixed assets increases their productivity and operational efficiency, while reducing the probability of losses caused by equipment failure as a result of systemic depreciation. Decrease in the rate of fixed assets reproduction leads to decline in production capacity and productivity level, increase in repair costs, decrease in the quality and competitiveness of products, reduction of income. The condition and degree of efficiency of fixed assets use affect the final results of economic activity of organizations of all forms of ownership and organizational and legal forms. The aim of this study is to assess the condition of fixed assets of enterprises and organizations in the territories of the regions included in the Arctic zone of the Russian Federation, since it is their availability and quality that is the basis for sustainable development and determines the available economic and production potential. Economic and statistical and comparative analysis were chosen as research methods. According to the results of the analysis, it was found out that the state of fixed assets in the Russian Federation as a whole is deteriorating, the measures taken to stimulate entrepreneurs to modernize production facilities, although caused some positive changes, but the expected results have not been achieved. The described situation is typical for the whole territory of the country, but it is especially relevant for the Arctic zone, where the realization of large-scale production and infrastructure projects is planned in the near future. To solve this problem will require joint efforts and interest in the result not only from the state, but also from business.
TRENDS AND PROSPECTS OF SERVICE MARKET OF RUSSIAN FEDERATION BY THE EXAMPLE OF CONGRESS AND EXHIBITION ACTIVITIES
Authors: Конюшенко Д.С.
Published: December 2023

Для эффективного управления конгрессно-выставочной деятельностью необходим анализ тенденций её развития на территории страны, поскольку совершенствование инфраструктуры данной отрасли влияет не только на привлечение дополнительных налоговых поступлений, но и на развитие качества и степени доступности услуг и объектов для населения регионов. В статье были выявлены отличительные черты конгрессно-выставочной отрасли в РФ, отмечены актуальные тенденции в области проведения конгрессно-выставочных мероприятий, проведен анализ количественных характеристик собственных и заказных событий в сфере соответствующих услуг.

To effectively manage congress and exhibition activities we need to analyze its development trends on the territory of the country, as the improvement of the infrastructure results not only in increasing tax revenues but also affects the quality and accessibility of services and objects for the population in regions. We reveal features of the congress and exhibition industry in the Russian Federation, as well as current trends concerning congress and exhibition events. We also analyze the quantitative characteristics of own and made to order events in the sphere in question.
CONCEPT AND CRIMINAL LEGAL ANALYSIS OF CRIMES ASSOCIATED WITH INVOLVEMENT OF MINORS INTO PROSTITUTION
Authors: Тертычная И.В. , Аксенов Д.В.
Published: December 2023

В статье раскрыта проблема вовлечения несовершеннолетних в занятие проституцией. Утверждается, что активное развитие IT-технологий стало толчком для расширения сферы преступлений против несовершеннолетних, поскольку интернет-пространство расширило возможности для их совершения. Сегодня одним из приоритетных направлений деятельности со стороны государства является предотвращение вовлечения несовершеннолетних в указанную сферу. Авторами статьи рассмотрено понятие преступлений, связанных с вовлечением несовершеннолетних в занятие проституцией, а также проведен их уголовно-правовой анализ.

The article reveals the problem of involving minors in prostitution. The active development of IT technologies has become an impetus for expanding the scope of crimes against minor, the Internet space has given attackers a free hand. Today, one of the priority areas of activity on the part of the state is to prevent the involvement of minors in this area of activity. The article discusses the concept and criminal legal analysis of crimes related to the involvement of minors in prostitution.
CONCEPT OF NATURE OF LATENT CRIME
Authors: Теохаров А.К.
Published: December 2023

В статье проанализированы вопросы, связанные с латентной преступностью как криминологическим явлением. Приведены существующие в отечественной и зарубежной литературе определения понятия «латентная преступность», осуществлен ихкритический анализ. В результате дано авторское определение исследуемого понятия. Показана специфика соотношения между латентностью и общественной опасностью преступлений. Обращено внимание на необходимость использования современных методов выявления преступлений, обеспечивающих более объективную оценку их латентности.

The article analyses latent crime as a criminological phenomenon. It provides relevant concepts available in foreign and domestic literature with a critical analysis thereof being conducted and the author’s own definition of this concept being introduced. A certain specific is noted with regard to correlation between latency and public danger of crimes. Particular attention is paid to the need for applying contemporary methods of crime detection which would enable more objective assessment of their latency.
FEATURES OF MANAGING FINANCIAL RISKS OF INVESTMENT PROJECTS
Authors: Дмитриева В.А.
Published: December 2023

Актуальность статьи заключается в том, что происходящее в последние годы усложнение инвестиционных процессов и дефицит финансовых ресурсов сопровождаются увеличением потенциальных рисков, снижающих эффект инвестиций. Профессиональное управление рисками имеет особо важное значение для улучшения инвестиционного климата и международной инвестиционной деятельности в крупных проектах в энергетике, инфраструктуре, промышленности и других отраслях.

The relevance of the research is determined by the fact that the recent growing complexity of investment processes and the deficit of financial resources entail the growth of potential risks decreasing the investment effect. Professional risk management is of key importance for the improvement of investment climate and international investment activity in big projects in energy production, infrastructure, industry, etc.
CRIMINAL RESPONSIBILITY FOR EVASION OF MILITARY OR ALTERNATIVE CIVIL SERVICE: CONTROVERSIAL ISSUES OF QUALIFICATION
Authors: Бозиев Т.О. , Коротков А.В.
Published: December 2023

В статье исследованы спорные вопросы квалификации преступления, предусмотренного ст. 328 «Уклонение от прохождения военной и альтернативной гражданской службы» Уголовного кодекса Российской Федерации (УК РФ). Несмотря на длительное существование нормы в доктринальных источниках, а также при практическом применении часто возникают дискуссии относительно вопроса о субъекте рассматриваемого преступления. Особенно обострилась ситуация в период прохождения мобилизационных мероприятий при проведении специальной военной операции. Проведен анализ действующего уголовного законодательства, законодательства, регулирующего прохождение военной или альтернативной гражданской службы, изучена судебная практика, а также исследованы комментарии, учебники, иная специальная литература, материалы, представленные в сети Интернет. Авторами предпринята попытка обосновать современный взгляд на квалификацию рассматриваемого преступления, распространение указанной статьи на лиц, уклоняющихся от мобилизации. Выделены основные подходы, позволяющие определять признаки субъекта преступления в связи с уклонением от прохождения военной и альтернативной гражданской службы.

The article deals with controversial issues of qualifying the crime under Art.328 of the Criminal Code of the Russian Federation — evasion of military or alternative civil service. Despite long existence of the relevant provision in doctrinal sources and practical application thereof controversial issues arise with regard to the subject of the crime in question. Thus the situation has especially worsened during mobilization activities under special military operation. The article provides analysis of the current criminal law, the legislation regulating performance of military and alternative civil service, court practice as well as comments and textbooks and other special literature including Internet. The authors have made an attempt to justify the modern view on qualification of the crime in question as well as on applying the related article to individuals evading mobilization. The authors have outlined major approaches enabling to identify elements of subject of crime related to evasion of military and alternative civil service.
SPECIFIC ISSUES OF LEGAL PERSONALITY OF INSOLVENCY PARTIES (BANKRUPTCY)
Authors: Пиддубривная А.Ю. , Кудрявцев Ю.А.
Published: December 2023

В статье рассмотрены вопросы, связанные с возможностью участия в делах о несостоятельности (банкротстве), определенных субъектов. В частности, раскрыта сущность правового статуса иностранного гражданина, показаны возможность применения процедур несостоятельности (банкротства) к несовершеннолетним гражданам, а также правовое положение прокурора при вступлении в процесс в порядке, указанном в ст. 52 Арбитражного процессуального кодекса Российской Федерации.

The article deals with specific issues covering the opportunity of certain actors to participate in insolvency cases. In particular, the study reveals legal status of a foreign citizen, possibility to apply insolvency procedure with regard to underaged citizens, legal status of prosecutor in the course of joining the process as indicated in Art.52 of the Arbitration Procedural Code of the Russian Federation.
MEDIATION IN CIVIL PROCEEDINGS IN THE REPUBLIC OF AUSTRIA
Authors: Васильчикова Н.А. , Кузбагарова В.А.
Published: December 2023

Статья посвящена анализу динамики развития процедуры медиации в Австрии. В исследовании раскрыт опыт данного государства в сфере поддержки развития медиации и распространения этой процедуры. Авторами проанализированы основные положения и специфика законодательства, в частности Закон Австрии «О медиации по гражданским делам». Уделено особое внимание принципу конфиденциальности при проведении медиации, порядку привлечения медиатора к ответственности, поддержке развития медиации, этапам медиации и требованиям к подготовке медиаторов, определению правовой природы соглашения между сторонами и медиатором.

The article deals with the analysis of the dynamics of mediation procedure development in Austria. The study demonstrates Austria's experience in supporting the development of mediation and its dissemination. The authors analyze basic provisions and specifics of special legislation in the form of the Austrian Civil Mediation Act, paying special attention to the principle of confidentiality in mediation, the mediator's liability procedure, support to mediation development, mediation stages and requirements for mediator training, definition of the legal nature of the agreement between the parties and the mediator.
ON POSSIBILITY OF USING MODERN TECHNOLOGIES FOR CONVERTING TESTIMONY TO DRAW UP INTERROGATION PROTOCOL IN CRIMINAL PROCEEDINGS
Authors: Сотников К.И. , Парамонова Г.В.
Published: December 2023

В статье утверждается, что современная следственная практика свидетельствует о тенденции увеличения объема составляемых протоколов допроса. Составление протокола допроса является наиболее трудоемким заключительным этапом данного следственного действия. Авторами поставлена задача внедрения в практику допроса современных компьютерных технологий, искусственного интеллекта, позволяющих преобразовывать устную речь в текст в виде цифровой информации. Использование конвертации устной речи в текст, по мнению авторов, будет способствовать полноте и объективности фиксируемых показаний, ускорению процесса составления протокола, более эффективному применению тактических приемов допроса.

The article states that the modern investigative practices indicate an increasing trend with regard to the volumes of interrogation protocols. Drawing up an interrogation protocol is the most labor consuming final stage of the investigative action. The authors set the task of implementing into interrogation practices modern computer technologies and artificial intelligence, allowing to transform speech to text in the form of digital information. The use of techniques of converting speech to text according to the authors will contribute to completeness and objectivity of recorded testimony as well as to speeding up the process of drawing up a protocol and will promote for more efficient implementation of tactical interrogation techniques.
Mejora de prácticas pedagógicas en matemáticas desde la perspectiva intercultural en la Educación Básica Primaria
Authors: Bucheli Chaves Carlos Iván , Sotomonte Publio Suárez
Published: December 2023

Uno de los problemas de la enseñanza-aprendizaje está en la atención a la diversidad. El problema se encuentra en el desarrollo de las prácticas pedagógicas, donde no se tiene en cuenta que cada alumno aprende desde sus intereses y necesidades. El propósito de este trabajo fue: articular la educación matemática a la interculturalidad desde diversos enfoques, y proponer una estrategia didáctica para el aprendizaje. La investigación asumió enfoques: Cualitativo y Ontosemiótico; paradigmas: Interpretativo y Crítico-social; tipo: Investigación-Acción e Investigación Situada. La metodología se desarrolló en 6 etapas que permitieron recolectar información para interpretarla, analizarla, evaluar, reflexionar, discutirla y tomar decisiones en consenso. Se analizaron 47 documentos publicados, entre 2018 - 2023, sobre educación matemática e interculturalidad y se realizó trabajo de campo con 5 profesores de matemáticas y 2 directivos de Básica Primaria en la Institución Educativa Libertad en Pasto-Colombia. Como resultado de la investigación, se articuló la matemática educativa con la interculturalidad, para identificar las diferentes prácticas susceptibles de mejora, problematizarlas y contextualizarlas. Se acordó establecer una comunidad de práctica con profesores y una comunidad de aprendizaje con estudiantes y padres de familia, comonestrategias de reflexión y aprendizaje de las matemáticas.
Stereoselective Hydroxyallylation of Cyclopropenes with Cyclopropanols via NHC Catalysis of Transient Organozinc Species
Authors: Tsukiji Kento , Matsumoto Arimasa , Kanemoto Kazuya , Yoshikai Naohiko
Published: December 2023

A stereoselective hydroxyallylation reaction of cyclopropenes with cyclopropanols is achieved under zinc-mediated conditions, affording densely functionalized cyclopropanes with excellent diastereocontrol over three contiguous stereocenters within and outside the cyclopropane ring. A racemic variant of the reaction is synergistically promoted by catalytic N-heterocyclic carbene (NHC) and organic base (DBU), whereas chiral amino alcohol-derived bifunctional NHC enables a catalytic enantioselective variant. Mechanistically, the reaction features transient generation of enolized zinc homoenolate via ring-opening of zinc cyclopropoxide and enolization of the resulting homoenolate, followed by its addition to the cyclopropene as a prochiral allylzinc nucleophile.
Three-dimensional van der Waals Open Frameworks
Authors: Tokuda Shun , Furukawa Shuhei
Published: December 2023

Open framework materials are constructed by connecting molecular components via strong bonds. Here, we show van der Waals interaction, which has been believed to be too weak for the framework construction, joints molecular building blocks into a series of robust three-dimensional frameworks, so-called van der Waals frameworks (WaaFs). The success relies on the use of metal-organic polyhedra (MOPs) with a size over 2 nm as building blocks. The well-defined faces composed of large aromatic molecules increase the intermolecular contact area to gain interaction energy over 400 kJ/mol. The octahedral shape of MOPs directs their packing into a diamond network with large extrinsic porosity. We confirm that one of the WaaFs shows over 2,000 m2 g-1 specific surface area.