bluuebunny/crossref_metadata_2025 huggingface dataset:
A novel MYC-ZNF706-SLC7A11 regulatory circuit contributes to cancer progression and redox balance in human hepatocellular carcinoma
Authors: Chu Jie , Jiang Jun , Fan Xin , Liu Jun , Gao Ke , Jiang Yu , Li Mengxuan , Xi Wenjin , Zhang Lu , Bian Ka , Yang Angang , Zhang Rui
Published: June 2024

The oncogenic potential of chromosome 8q22 copy number gain in liver cancer remains to be depicted. Here, we report that ZNF706, encoded by a gene mapped to chromosome 8q22, is a C2H2-type zinc finger protein. However, the biological function and mechanism of ZNF706 have been poorly investigated. Clinically, ZNF706 expression was elevated in hepatocellular carcinoma (HCC), and high ZNF706 expression was associated with unfavorable survival in HCC patients. Functional experiments revealed that ZNF706 knockdown inhibited HCC progression both in vitro and in vivo. RNA sequencing (RNA-seq) and chromatin immunoprecipitation-based deep sequencing (ChIP-seq) revealed that mechanistically, ZNF706 is a crucial ferroptosis regulator and that SLC7A11 is a critical target of ZNF706. In addition, ZNF706 knockdown inhibited SLC7A11 expression, increased lipid peroxidation, and promoted ferroptosis. Further analysis revealed that ZNF706 is a novel direct target transcriptionally activated by MYC in HCC cells. Importantly, MYC depletion reduced SLC7A11-mediated redox homeostasis, and this effect was reversed by ZNF706 reexpression. Collectively, our data demonstrate that ZNF706 is a potential oncogene in liver cancer and functions as a ferroptosis regulator by modulating SLC7A11 expression, constituting a potential therapeutic target for HCC.
AidData’s Geospatial Global Chinese Development Finance Dataset
Authors: Goodman Seth , Zhang Sheng , Malik Ammar A. , Parks Bradley C. , Hall Jacob
Published: June 2024

AidData’s Global Chinese Development Finance Dataset (Version 3.0) provides detailed information about more than 20,000 development projects across 165 low- and middle-income countries financed by 791 official sector Chinese donors and lenders from 2000 to 2021. In this study, we introduce a methodology for identifying the geospatial features of these projects. Our application of the methodology has resulted in the Geospatial Global Chinese Development Finance Dataset (Version 3.0), which captures the geospatial features of 9,405 projects across 148 low- and middle-income countries supported by Chinese grant and loan commitments worth more than USD 830 billion. The dataset provides details for 6,266 projects containing spatial definitions of roads, railways, power plants, transmission lines, buildings, and other precisely geocoded features. It identifies approximate and administrative-level locations for 3,139 additional projects. The methodology, dataset, and the code used to construct the dataset have been made publicly available to facilitate replication and future applications.
Comprehensive analysis of optimal power flow using recent metaheuristic algorithms
Authors: Diab Ahmed A. Zaki , Abdelhamid Ashraf M. , Sultan Hamdy M.
Published: June 2024

This paper provides six metaheuristic algorithms, namely Fast Cuckoo Search (FCS), Salp Swarm Algorithm (SSA), Dynamic control Cuckoo search (DCCS), Gradient-Based Optimizer (GBO), Northern Goshawk Optimization (NGO), Opposition Flow Direction Algorithm (OFDA) to efficiently solve the optimal power flow (OPF) issue. Under standard and conservative operating settings, the OPF problem is modeled utilizing a range of objectives, constraints, and formulations. Five case studies have been conducted using IEEE 30-bus and IEEE 118-bus standard test systems to evaluate the effectiveness and robustness of the proposed algorithms. A performance evaluation procedure is suggested to compare the optimization techniques' strength and resilience. A fresh comparison methodology is created to compare the proposed methodologies with other well-known methodologies. Compared to previously reported optimization algorithms in the literature, the obtained results show the potential of GBO to solve various OPF problems efficiently.
A grounded theory on acceptance of diagnosis as a pathway to recovery in bipolar disorder
Authors: Pereira Caroline Silveira , Padoan Carolina Stopinski , Silva Marielle Moro , Magalhães Pedro V. S.
Published: June 2024

The recovery process in bipolar disorder is a subjective and multidimensional experience that seeks to develop new meanings and purposes for living a satisfying life despite the limitations imposed by the disorder. Thus, this qualitative study aimed to explore the perceptions of recovery and the meanings attributed by individuals undergoing treatment for bipolar disorder to the elements considered relevant in this process. Semi-structured interviews with open-ended questions were conducted to explore the experiences and perspectives of recovery in individuals undergoing treatment for bipolar disorder. Grounded Theory was used as the method for qualitative analysis. The study included 26 participants aged between 18 and 65 years. Based on the analysis of participant reports, we identified two main themes: living with the illness and what it means to be in recovery. The perception of recovery is an individual process and can differ from the medical model. Participants suggest that accepting the diagnosis of bipolar disorder and finding meaning in life are essential to their recovery. They also describe how mental health professionals can facilitate or hinder this process. Understanding patients’ perceptions can facilitate access to healthcare services and treatment adherence.
Sialyllactose preserves residual hearing after cochlear implantation
Authors: Lee Min Young , Jung Seo-Kyung , Jang Jongmoon , Choi Hongsoo , Choung Yun-Hoon , Jang Jeong Hun
Published: June 2024

In individuals with hearing loss, protection of residual hearing is essential following cochlear implantation to facilitate acoustic and electric hearing. Hearing preservation requires slow insertion, atraumatic electrode and delivery of the optimal quantity of a pharmacological agent. Several studies have reported variable hearing outcomes with osmotic pump-mediated steroid delivery. New drugs, such as sialyllactose (SL) which have anti-inflammatory effect in many body parts, can prevent tissue overgrowth. In the present study, the positive effects of the pharmacological agent SL against insults were evaluated in vitro using HEI-OC1 cells. An animal model to simulate the damage due to electrode insertion during cochlear implantation was used. SL was delivered using osmotic pumps to prevent loss of the residual hearing in this animal model. Hearing deterioration, tissue fibrosis and ossification were confirmed in this animal model. Increased gene expressions of inflammatory cytokines were identified in the cochleae following dummy electrode insertion. Following the administration of SL, insertion led to a decrease in hearing threshold shifts, tissue reactions, and inflammatory markers. These results emphasize the possible role of SL in hearing preservation and improve our understanding of the mechanism underlying hearing loss after cochlear implantation.
Evaluating the Shock Index, Revised Assessment of Bleeding and Transfusion (RABT), Assessment of Blood Consumption (ABC) and novel PTTrauma score to predict critical transfusion threshold (CAT) in penetrating thoracic trauma
Authors: Barbosa Rengifo Mario Miguel , Garcia Alberto F. , Gonzalez-Hada Adolfo , Mejia Nancy J.
Published: June 2024

The shock index (SI) has been associated with predicting transfusion needs in trauma patients. However, its utility in penetrating thoracic trauma (PTTrauma) for predicting the Critical Administration Threshold (CAT) has not been well-studied. This study aimed to evaluate the prognostic value of SI in predicting CAT in PTTrauma patients and compare its performance with the Assessment of Blood Consumption (ABC) and Revised Assessment of Bleeding and Transfusion (RABT) scores. We conducted a prognostic type 2, single-center retrospective observational cohort study on patients with PTTrauma and an Injury Severity Score (ISS) > 9. The primary exposure was SI at admission, and the primary outcome was CAT. Logistic regression and decision curve analysis were used to assess the predictive performance of SI and the PTTrauma score, a novel model incorporating clinical variables. Of the 620 participants, 53 (8.5%) had more than one CAT. An SI > 0.9 was associated with CAT (adjusted OR 4.89, 95% CI 1.64–14.60). The PTTrauma score outperformed SI, ABC, and RABT scores in predicting CAT (AUC 0.867, 95% CI 0.826–0.908). SI is a valuable predictor of CAT in PTTrauma patients. The novel PTTrauma score demonstrates superior performance compared to existing scores, highlighting the importance of developing targeted predictive models for specific injury patterns. These findings can guide clinical decision-making and resource allocation in the management of PTTrauma.
Compliance level and associated factors of iron folic acid supplementation among pregnant women in North Shoa Zone, Ethiopia
Authors: Ejara Daba , Ferede Amsal , Shifa Jemal Ebrahim , Bekele Fikadu , Ahmed Hassen Tahir
Published: June 2024

Iron deficiency is a widespread micronutrient deficiency, impacting over 30% of the global population. Iron Folic Acid supplement is recommended for pregnant women to counter iron deficiency anemia and neural tube anomalies. Although Iron Folic Acid supplementation is integral to Ethiopian antenatal care, one in four women in Ethiopia experiences anemia during pregnancy suggesting poor compliance. This study aimed to investigate compliance level and associated factors of Iron Folic Acid supplementation among pregnant women attending antenatal care in Wuchale Woreda of North Shoa Zone, Ethiopia. An institutional-based cross-sectional study was conducted among 302 pregnant women from March 20 to April 5, 2021, who were selected using a systematic random sampling technique. Data were collected through face-to-face interview, entered epi-data, and exported to Statistical Package for the Social Sciences for analysis. A multivariable logistic regression was used to identify factors associated with compliance level. All the results were presented with 95% confidence intervals. The compliance with Iron Folic Acid supplementation was 47.0%. Residing nearest to the health facility (AOR = 2.46; 95% CI 1.32, 4.57), initiating antenatal care at health center (AOR = 2.23; 95% CI 1.17, 4.51), having a family size of 4 and above (AOR = 4.99; 95% CI 2.43, 10.24), and receiving information from health extension workers (AOR = 5.52; 95% CI 1.30, 23.54) increased compliance with Iron Folic Acid supplementation. Less than half of the pregnant women were compliant with Iron Folic Acid utilization. There is a need to prioritize promoting the importance of Iron Folic Acid supplementation through health education particularly by targeting pregnant women with identified factors.
Resting state neurophysiology of agonist–antagonist myoneural interface in persons with transtibial amputation
Authors: Chicos Laura A. , Rangaprakash D. , Srinivasan Shriya S. , Gutierrez-Arango Samantha , Song Hyungeun , Barry Robert L. , Herr Hugh M.
Published: June 2024

The agonist–antagonist myoneural interface (AMI) is an amputation surgery that preserves sensorimotor signaling mechanisms of the central-peripheral nervous systems. Our first neuroimaging study investigating AMI subjects conducted by Srinivasan et al. (2020) focused on task-based neural signatures, and showed evidence of proprioceptive feedback to the central nervous system. The study of resting state neural activity helps non-invasively characterize the neural patterns that prime task response. In this study on resting state functional magnetic resonance imaging in AMI subjects, we compared functional connectivity in patients with transtibial AMI (n = 12) and traditional (n = 7) amputations (TA). To test our hypothesis that we would find significant neurophysiological differences between AMI and TA subjects, we performed a whole-brain exploratory analysis to identify a seed region; namely, we conducted ANOVA, followed by t-test statistics to locate a seed in the salience network. Then, we implemented a seed-based connectivity analysis to gather cluster-level inferences contrasting our subject groups. We show evidence supporting our hypothesis that the AMI surgery induces functional network reorganization resulting in a neural configuration that significantly differs from the neural configuration after TA surgery. AMI subjects show significantly less coupling with regions functionally dedicated to selecting where to focus attention when it comes to salient stimuli. Our findings provide researchers and clinicians with a critical mechanistic understanding of the effect of AMI amputation on brain networks at rest, which has promising implications for improved neurorehabilitation and prosthetic control.
Low complexity beamforming design in reconfigurable intelligent surface-assisted communication systems
Authors: Jiang Jun , Huang Huan , Zhang Junxin
Published: June 2024

Due to the possibility of blockage during communication, the communication quality may be poor. Therefore, Reconfigurable Intelligent Surface (RIS) technology can effectively solve this problem. In order to increase the capacity of RIS-assisted wireless communication systems, joint optimization of beamforming design is crucial. However, the complexity of the optimization algorithm increases with the increase in the number of base station antennas and RIS elements deployed. Therefore, we propose a joint low-complexity optimization beamforming design based on fractional programming (FP) to address this issue. Specifically, we first use perfect channel state information to maximize the system's sum rate, as this problem is non-convex, we decompose the original problem into three sub-problems, and then introduce appropriate auxiliary variables. We derive optimal closed-form solutions for active and passive beamforming types, respectively. As the optimal solution obtained leads to higher computational complexity with an increase in the number of base station antennas and RIS elements, we reduce the computational complexity of obtaining the optimal solution based on the Woodbury transformation and scalar transformation. The proposed algorithm is also extended to the case where there is channel state information error. Finally, simulation results show that the proposed algorithm has certain advantages over other algorithms.
Cortical processes of multisensory plausibility modulation of vibrotactile perception in virtual environments in middled-aged and older adults
Authors: Kang Kathleen Y. L. , Rosenkranz Robert , Altinsoy Mehmet Ercan , Li Shu-Chen
Published: June 2024

Digital technologies, such as virtual or augmented reality, can potentially support neurocognitive functions of the aging populations worldwide and complement existing intervention methods. However, aging-related declines in the frontal-parietal network and dopaminergic modulation which progress gradually across the later periods of the adult lifespan may affect the processing of multisensory congruence and expectancy based contextual plausibility. We assessed hemodynamic brain responses while middle-aged and old adults experienced car-riding virtual-reality scenarios where the plausibility of vibrotactile stimulations was manipulated by delivering stimulus intensities that were either congruent or incongruent with the digitalized audio-visual contexts of the respective scenarios. Relative to previous findings observed in young adults, although highly plausible vibrotactile stimulations confirming with contextual expectations also elicited higher brain hemodynamic responses in middle-aged and old adults, this effect was limited to virtual scenarios with extreme expectancy violations. Moreover, individual differences in plausibility-related frontal activity did not correlate with plausibility violation costs in the sensorimotor cortex, indicating less systematic frontal context-based sensory filtering in older ages. These findings have practical implications for advancing digital technologies to support aging societies.
Potential distribution prediction of Ceracris kiangsu Tsai in China
Authors: Fu Chun , Wen Xuanye , Shi Zhaopeng , Rui Lin , Jiang Na , Zhao Gelin , Wang Rulin , Zhao Jinpeng , Yang YaoJun
Published: June 2024

Ceracris kiangsu Tsai (C. kiangs) is a kind of forest pest, which can harm nearly 100 kinds of weeds and crops. In this study, based on 314 species distribution points of C. kiangsu which were obtained from Chinese herbaria, literatures and investigation, and data of three future climate scenarios presented by CMIP6, two niche models (Garp, Maxent) were used to predict the suitable area of C. kiangsu in China. The result shows that the main environmental factors affecting the distribution of C. kiangsu are precipitation of driest month (bio14) and min temperature of coldest month (bio6). No matter now and future, the potential distribution areas of C. kiangsu in China are mainly in the south of Qinling–Huaihe River. Under current scenarios, the areas of the total, highly, moderately and poorly suitable of C. kiangsu in China are 160.65 × 104 km2, 31.70 × 104 km2, 60.36 × 104 km2 and 68.59 × 104 km2 respectively. The southern Hubei, western Jiangxi and eastern Hunan are highly-suitable areas. Under SSP1-2.6 and SSP2-4.5 scenarios, both the total suitable area and the highly suitable show a decreasing tread in 2050s. Compared to the 2050s, the total suitable area will coninue to decease in 2090s under SSP1-2.6, while it will increase under SSP2-4.5. The highly suitable area will increase in both scenarios, and the increased percentage under SSP2-4.5 is greater than that under SSP1-2.6. Under SSP5-8.5 scenarios, the total suitable area will increase by 1.83% in the 2050s, and decrease by 1.17% in the 2090s. The highly suitable area in the 2050s and 2090s under this scenarios is larger than under current scenarios. No matter what the scenario, the southern part of Yunnan, the southeast of Sichuan and the southwest of Chongqing will become highly-suitable areas as the climate continues to warm and should be monitored more cosely.
Influence mechanism of grinding surface quality of 20CrMnTi steel on contact failure
Authors: Wang Long , Yang Lijun , Wang Liuying , Tang Xiujian , Liu Gu
Published: June 2024

To reveal the influence mechanism of the grinding surface quality of 20CrMnTi steel components on the tribological characteristics and contact fatigue performance, accelerated tests for sliding friction wear and fatigue damage were carried out. Tribological characteristics and contact fatigue performance get worse with increasing surface roughness while getting better with increasing surface microhardness. Residual compressive stress is conducive to inhibiting the initiation and propagation of cracks and promoting contact fatigue performance. Additionally, mechanical friction, abrasive wear, adhesive wear and fatigue damage coexist and form a competing failure mechanism under the synergistic effect of frictional wear and contact fatigue failure. The damage process mainly manifests as wear, stress concentration induced fatigue, microcracks, pitting, and spalling in the shallow layer. This study is more beneficial to promote the 20CrMnTi steel transmission parts manufacturing products for high precision, low damage, and long life.
Molecular dynamics simulation on regulation of liquid–liquid phase separation of repetitive peptides
Authors: Yang Xiaojun , Wang Yanwei , Yang Guangcan
Published: June 2024

Understanding the intricate interactions governing protein and peptide behavior in liquid–liquid phase separation (LLPS) is crucial for unraveling biological functions and dysfunctions. This study employs a residue-leveled coarse-grained molecular dynamics approach to simulate the phase separation of repetitive polyproline and polyarginine peptides (poly PR) with varying lengths and sequences in solution, considering different concentrations and temperatures. Our findings highlight the crucial role of sequence order in promoting LLPS in peptides with identical lengths of repetitive sequences. Interestingly, repetitive peptides containing fewer than 10 polyarginine repeats exhibit no LLPS, even at salt concentrations up to 3 M. Notably, our simulations align with experimental observations, pinpointing a salt concentration of 2.7 M for PR25-induced LLPS. Utilizing the same methodology, we predict the required salt concentrations for LLPS induction as 1.2 M, 1.5 M, and 2.7 M for PR12, PR15, and PR35, respectively. These predictions demonstrate good agreement with experimental results. Extending our investigation to include the peptide glutamine and arginine (GR15) in DNA solution, our simulations mirror experimental observations of phase separation. To unveil the molecular forces steering peptide phase separation, we introduce a dielectric constant modifier and hydrophobicity disruptor into poly PR systems. Our coarse-grained analysis includes an examination of temperature effects, leading to the inference that both hydrophobic and electrostatic interactions drive phase separation in peptide systems.
Factors associated with phenotypes of dyspnea in post-COVID-19 condition: a cross-sectional study
Authors: Smith Maeve P. , Sharpe Heather , Damant Ronald W. , Ferrara Giovanni , Lim Rachel K. , Stickland Michael K. , Lam Grace Y.
Published: June 2024

Post-COVID-19 condition (PCC) is defined as the persistence of symptoms, like fatigue and dyspnea, at least 3 months post-COVID infection. As dyspnea is a common symptom, we attempted to further clinically phenotype those with PCC-associated dyspnea. 1642 adults (average age of 49.6y with 63% female-predominance and BMI of 31.2 kg/m2) with physician confirmed diagnosis of PCC from June 2020–April 2023 in Alberta, Canada were included. Those with dyspnea were more likely to be female (56.5%, p = 0.005) and have higher BMI (31.3 kg/m2 vs. 29.5 kg/m2; p = 0.0008), history of asthma (21.1% vs. 12.3%; p < 0.001), more persistent PCC symptoms (p = 0.0001), more functional limitations, as well as lower quality of life (p < 0.0001). Multivariable-adjusted logistic regression analysis demonstrated dyspnea was independently associated with fatigue (OR = 4.20; CI = 2.71,6.59) and inversely associated with hospitalization for COVID-19 (OR = 0.53; CI = 0.32,0.91), age (OR = 0.98 per one year of age; CI = 0.96,0.99) and 6-min-walk-distance per 10 m difference (OR = 0.98, CI = 0.96,1.0). Fatigue was a predictor of dyspnea, and was associated with milder infection, higher BMI, and reduced 6-min-walk-distance despite normal pulmonary function. Reduced TLC or DLCO was associated with more severe infection and reduced 6-min-walk-distance. Thus, we speculate there are at least two dyspnea-associated phenotypes: phenotype with pronounced fatigue (normal PFT) and phenotype with pronounced pulmonary abnormalities (abnormal PFT). Improved understanding of the dyspnea-associated phenotypes may allow for better targeted rehabilitation.
The kappa/lambda ratio of surface immunoglobulin light chain as a valuable parameter for MRD assessment in CLL with atypical immunophenotype
Authors: Aruga Yu , Ikeda Chiaki , Matsushita Hiromichi , Makita Shinichi , Fukuhara Suguru , Munakata Wataru , Izutsu Koji , Matsui Hirotaka
Published: June 2024

In recent years, the significance of detecting minimal/measurable residual disease (MRD) in chronic lymphocytic leukemia (CLL) has increased due to the availability of highly effective therapeutic agents. Flow cytometry provides notable cost-effectiveness and immediacy, with an expected sensitivity level of approximately 10−4. The critical aspect of MRD detection via flow cytometry lies in accurately defining the region containing tumor cells. However, a subset of CLL, known as CLL with atypical immunophenotype, exhibits a distinct cell surface marker expression pattern that can make MRD detection challenging, because these markers often resemble those of normal B cells. To enhance the sensitivity of MRD detection in such atypical cases of CLL, we have capitalized on the observation that cell surface immunoglobulin (sIg) light chains tend to be expressed at a higher level in this subtype. For every four two-dimensional plots of cell surface markers, we used a plot to evaluate the expression of sIg kappa/lambda light chains and identified regions where the kappa/lambda ratio of sIg light chains deviated from a designated threshold within the putative CLL cell region. Using this method, we could detect atypical CLL cells at a level of 10−4. We propose this method as an effective MRD assay.
Tracking the evolution of anti-SARS-CoV-2 antibodies and long-term humoral immunity within 2 years after COVID-19 infection
Authors: Movsisyan Mariam , Truzyan Nune , Kasparova Irina , Chopikyan Armine , Sawaqed Ra’ed , Bedross Alexandra , Sukiasyan Meline , Dilbaryan Karen , Shariff Sanobar , Kantawala Burhan , Hakobjanyan Gohar , Petrosyan Gayane , Hakobyan Armine , Yenkoyan Konstantin
Published: June 2024

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that gave rise to COVID-19 infection produced a worldwide health crisis. The virus can cause a serious or even fatal disease. Comprehending the complex immunological responses triggered by SARS-CoV-2 infection is essential for identifying pivotal elements that shape the course of the disease and its enduring effects on immunity. The span and potency of antibody responses provide valuable perspicuity into the resilience of post-infection immunity. The analysis of existing literature reveals a diverse controversy, confining varying data about the persistence of particular antibodies as well as the multifaceted factors that impact their development and titer, Within this study we aimed to understand the dynamics of anti-SARS-CoV-2 antibodies against nucleocapsid (anti-SARS-CoV-2 (N)) and spike (anti-SARS-CoV-2 (N)) proteins in long-term immunity in convalescent patients, as well as the factors influencing the production and kinetics of those antibodies. We collected 6115 serum samples from 1611 convalescent patients at different post-infection intervals up to 21 months Study showed that in the fourth month, the anti-SARS-CoV-2 (N) exhibited their peak mean value, demonstrating a 79% increase compared to the initial month. Over the subsequent eight months, the peak value experienced a modest decline, maintaining a relatively elevated level by the end of study. Conversely, anti-SARS-CoV-2 (S) exhibited a consistent increase at each three-month interval over the 15-month period, culminating in a statistically significant peak mean value at the study’s conclusion. Our findings demonstrate evidence of sustained seropositivity rates for both anti-SARS-CoV-2 (N) and (S), as well as distinct dynamics in the long-term antibody responses, with anti-SARS-CoV-2 (N) levels displaying remarkable persistence and anti-SARS-CoV-2 (S) antibodies exhibiting a progressive incline.
Structural diversity of supramolecular networks formed between polycyanometalates and sulfur-based chalcogen bond donors
Authors: Streit Tim-Niclas , Langwald Jan , Gomila Rosa M. , Frontera Antonio , Malischewski Moritz
Published: June 2024

Polycyanometalates can act as polydentate chalcogen bond acceptors when combined with sulfonium cations.
Facet junction engineering for enhanced SERS activity of Ag/Cu2O composite substrates
Authors: Zhou Ming , He Xunfei , Gong Yinyan , Li Can , Niu Lengyuan
Published: June 2024

Ag/Cu2O(J) exhibits higher SERS activity than Ag/Cu2O(C) and Ag/Cu2O(O), due to its enhanced charge-transfer ability, promoted by the {100}/{111} crystallographic facet junction and rich oxygen vacancies.
Process intensification in the fields to separate, recycle and reuse waste through membrane technology
Authors: Panda Swapna Rekha , Asthana Sudeep , Suthar Krunal , Madalgi Arvind S. , Kumar Amit , Dave Haresh , Sinha Rakesh Kumar , Kishor Koshal , Ismail Ahmad F.
Published: June 2024

PI strategies industrial waste-treatment integrated with membranes, hybrid-mode for separation of L–G–V at early-stage research. Scalable, energy-efficient, minimal-toxicant usage of PI is an eco-friendly-greener and sustainable industrial practice.
A novel strategy to prepare high performance multifunctional composite films by combining electrostatic assembly, crosslinking, topology enhancement and sintering
Authors: Zhang Xuezhong , Wu Die , Zhou Hongju , Xiang Dong , Sun Haoming , Chen Chuanliang , Li Dong , Wu Yuanpeng , Fu Qiang , Deng Hua
Published: June 2024

High-performance films were prepared by combining electrostatic assembly, chemical crosslinking, topological enhancement and sintering.
Suppressing Jahn–Teller distortion and locking lattice water with doped Fe(iii) in birnessite toward fast and stable zinc-ion batteries
Authors: Li Xiang , Sun Yanchun , Zhou Le , Wang Haiyan , Xie Binbin , Lu Wen , Ning Jiqiang , Hu Yong
Published: June 2024

A layered Fe–NMO·xH2O cathode is fabricated for stable aqueous ZIBs. Fe doping can alleviate the Jahn–Teller effect and lock lattice water, which prevents phase transformation and lattice collapse during the (de)intercalation process.
Synthesis of novel triazoles as anticancer agents targeting pJNK in human breast cancer cells
Authors: Siddappa Tejaswini P. , Bhol Chandra Sekhar , Ravish Akshay , Xi Zhang , Narasimhachar Bhanuprakash C. , Kumar Arun M. , Basappa Shreeja , Chinnathambi Arunachalam , Govindasamy Chandramohan , Gaonkar Santhosh L. , Lobie Peter E. , Pandey Vijay , Basappa Basappa
Published: June 2024

Breast cancer (BC) is the second-largest cause of cancer-related deaths among women worldwide.
A recyclable PDMS microfluidic surface-enhanced Raman scattering Cu/AgNP chip for the analysis of sulfadiazine in aquatic products
Authors: Huang Jianying , Xia Ling , Xiao Xiaohua , Li Gongke
Published: June 2024

In situ preparation of a PDMS microfluidic SERS Cu/AgNP chip for rapid SERS analysis of sulfadiazine in aquatic products.
One-step preparation of direct Z-scheme NH2-UiO-66/BiOCl photocatalyst for antibiotic degradation by electrostatic adsorption
Authors: Gao Yanhua , Liu Hongya , Zhang Dongfeng , Chen Ying , Liang Yuning , Ren Juan
Published: June 2024

One-step preparation of direct Z-scheme NH2-UiO-66/BiOCl photocatalyst.
Electrochemical hydrogenation of furfural under alkaline conditions with enhanced furfuryl alcohol selectivity by self-grown Cu on a Ag electrode
Authors: Wen Huiming , Fan Ziyi , Dou Shuo , Lam Jason Chun-Ho , Zhang Wenjun , Chen Zupeng
Published: June 2024

Efficient conversion of furfural to furfuryl alcohol with a high electron transport rate over Cu/PAg catalysts under alkaline conditions.
GSH/pH dual-activated POM@MOF for tumor cell-specific synergistic photothermal and chemodynamic therapy
Authors: Li Bole , Wu Zhujun , Xu Xiaotong , Lv Yanfei , Guo Yunfei , Liang Siyu , Wang Zhimin , He Lei , Song Yu-Fei
Published: June 2024

A tumor microenvironment-specifically activated POM@MOF was developed for PTT/CDT combination therapy against tumor cells.
A general photochemical strategy for the oximation of activated alkenes without a catalyst
Authors: Lan Hongyan , Su You , Chen Yikun , He Xiaozhi , Wang Dingyi
Published: June 2024

A general photochemical approach for the oximation of activated alkenes to synthesize diverse oximes without catalysts is described. The simple and modular method offers a new perspective for chemists to rapidly obtain various radical intermediates.
Swietemicrolides A–D, mexicanolide-type limonoids from the bark of Swietenia macrophylla with in vitro cytotoxic and α-glucosidase inhibitory activities
Authors: Tran Tu-Quyen Thi , Trinh Duong Hoang , Trinh Binh Thi Dieu , Bui Dzung Ngoc , Nguyen Lien-Hoa Dieu , Tran Phuong Thu
Published: June 2024

Four new mexicanolide-type limonoids, swietemicrolides A–D (1–4), together with three known compounds (5–7) were isolated from an ethyl acetate extract of the bark of Swietenia microphylla.
Ursolic acid inhibits NF-κB signaling and attenuates MMP-9/TIMP-1 in progressive osteoarthritis: a network pharmacology-based analysis
Authors: Zahran Eman Maher , Mohamad Soad A. , Elsayed Mohamed M. , Hisham Mohamed , Maher Sherif A. , Abdelmohsen Usama Ramadan , Elrehany Mahmoud , Desoukey Samar Yehia , Kamel Mohamed Salah
Published: June 2024

Osteoarthritis (OA) is a degenerative joint disease, characterized by infiltration of monocytes into the synovial joint which promotes inflammation, stiffness, joint swelling, cartilage degradation and further bone destruction.
Palladium nanoparticles for the synthesis of phenanthridinones and benzo[c]chromenes via C–H activation reaction
Authors: Díaz-Vázquez Eva D. , Cuellar Micaela A. , Heredia Micaela D. , Barolo Silvia M. , González-Bakker Aday , Padrón José M. , Budén María E. , Martín Sandra E. , Uberman Paula M.
Published: June 2024

The reactivity of Pd-PVP NPs was evaluated in C–H bond activation for heterocycles synthesis under mild conditions. Their in vitro activity against solid tumor cell lines was assessed, revealing potential as anticancer agents.
Adsorption behavior of different cresols on bismuthene: a DFT study
Authors: Iqrar Ukkasha , Masood Usman , Alarfaji Saleh S. , Iqbal Tahir , Majid Abdul , Isa Khan Muhammad
Published: June 2024

Phenolic compounds present in wastewater were utilized for first-principle calculations based on DFT to observe adsorption effects.
Modifying the electron structure of an FeCoNiZnCu high-entropy alloy with the introduction of Cu to facilitate the catalytic effect in lithium sulfur batteries
Authors: Chen Liping , Wu Dingding , Li Xin , Li Yong , Zu Guannan , Li Shuyue , Li Kai , Wang Juan
Published: June 2024

The d-band center distribution of high entropy alloys can be controlled by selecting appropriate elements, to optimize the adsorption-catalysis-diffusion of lithium polysulfide, developing highly active catalysts with bidirectionally catalytic activity.
Thermoelectrics for nuclear fusion reactors: opportunities and challenges
Authors: Tan Xian Yi , Liu Hongfei , Dong Jinfeng , Ngo Andrew Chun Yong , Suwardi Ady , Cao Jing
Published: June 2024

In this review, we discuss the promising applications and practical considerations of thermoelectrics to harvest the unutilized thermal gradient between the plasma-facing surfaces and the molten salt coolant loop in tokamak fusion reactors.
Wholly degradable quasi-solid-state thermocells for low-grade heat harvesting and precise thermal sensing
Authors: Hu Yifeng , Xie Daibin , Liu Zhaopeng , Xie Bin , Li Mingyu , Chen Guangming , Liu Zhuoxin
Published: June 2024

Flexible thermocell devices are designed with device-level degradability for low-grade heat harvesting and precise thermal sensing.
Deciphering the role of aromatic cations in electrochemical CO2 reduction: interfacial ion assembly governs reaction pathways
Authors: Guo Wenxiao , Liu Beichen , Anderson Seth R. , Johnstone Samuel G. , Gebbie Matthew A.
Published: June 2024

Imidazolium cations facilitate electrochemical CO2 reduction by (1) stabilizing CO2˙− with delocalized positive charge (π+) and (2) tuning the transport of proton donors to the electrochemical interface.
Engineering of a double targeting nanoplatform to elevate ROS generation and DSF anticancer activity
Authors: Li Wenqiu , Huang Haowu , Yao Shunyu , Zhao Yiwang , Liu Mingxing , Liu Xiaoqing , Guo Huiling
Published: June 2024

Schematic illustration of the preparation (a) and therapeutic mechanism (b) of CPMDTH.
Design and development of 3D printed shape memory triphasic polymer-ceramic bioactive scaffolds for bone tissue engineering
Authors: Ansari Mohammad Aftab Alam , Makwana Pooja , Dhimmar Bindiya , Vasita Rajesh , Jain Prashant Kumar , Nanda Himansu Sekhar
Published: June 2024

Scaffolds for bone tissue engineering require considerable mechanical strength to repair damaged bone defects.
Progress in ultrasmall ferrite nanoparticles enhanced T1 magnetic resonance angiography
Authors: Liu Minrui , Feng Quanqing , Zhang Huan , Guo Yingkun , Fan Haiming
Published: June 2024

Schematic diagram of design, regulation, and application of UFNPs.
In vitro and in vivo biocompatibility assessment of chalcogenide thermoelectrics as implants
Authors: Gao Mingyuan , Luo Yiping , Li Wen , Zheng Longpo , Pei Yanzhong
Published: June 2024

This study conducted the first comprehensive in vitro and in vivo biocompatibility assessment of twelve typical sulfide compounds, identifying promising thermoelectric biomaterials and establishing a foundation for their application in biomedicine.
Unveiling growth mechanisms of PEALD In2O3 thin films with amide-based versus alkyl-based novel indium precursors
Authors: Jeong Gyeong Min , Yang Hae Lin , Yoon Ara , Kim Yoon-Seo , Lee Sangick , Kwone Yonghee , Jeon Sangyong , Im Youngjae , Park Jin-Seong
Published: June 2024

New indium precursors based on alkyl and amine ligands make a difference in the properties of indium oxide thin films.
Emergence of promising n-type thermoelectric material through conductive network and strong phonon softening
Authors: Peter Jipin , Choudhary Tanu , Biswas Raju K
Published: June 2024

The synergistic effect of conductive network coupled with strong optical phonon softening and avoided crossing phenomena helps to achieve high thermoelectric performance in a quasi-ternary system.
Highly efficient and stable pure-red phosphorescent organic light-emitting diodes based on heptacyclic bipolar hosts featuring an armor-like structure
Authors: Meng Zhimin , Zhu Yanan , Li Hongyang , Zhang Xiaopeng , Shang Yifan , Kuang Changchun , Meng Hong
Published: June 2024

The armor-like heptacyclic framework enhances the rigidity and stability of host materials named Hept-TRZ. The luminescent devices based on Hept-TRZ as the red host achieve high efficiency and long lifetime of PhOLEDs.
Recent advances in lead-free halide perovskites: from synthesis to applications
Authors: Wang Yunuan , Liu Jianxiang , Liu Yujun , Li Shaopeng , Xu Xiulai , Lou Zhidong
Published: June 2024

The recent progress and development directions in lead-free perovskites are summarized from the perspective of device physics and materials science.
Does Gestural Communication Influence Later Spoken Language Ability in Minimally Verbal Autistic Children?
Authors: La Valle Chelsea , Shen Lue , Shih Wendy , Kasari Connie , Shire Stephanie , Lord Catherine , Tager-Flusberg Helen
Published: June 2024

Purpose:

The current study examined the predictive role of gestures and gesture–speech combinations on later spoken language outcomes in minimally verbal (MV) autistic children enrolled in a blended naturalistic developmental/behavioral intervention (Joint Attention, Symbolic Play, Engagement, and Regulation [JASPER] + Enhanced Milieu Teaching [EMT]).

Method:

Participants were 50 MV autistic children (40 boys), ages 54–105 months (
M
= 75.54,
SD
= 16.45). MV was defined as producing fewer than 20 spontaneous, unique, and socially communicative words. Autism symptom severity (Autism Diagnostic Observation Schedule–Second Edition) and nonverbal cognitive skills (Leiter-R Brief IQ) were assessed at entry. A natural language sample (NLS), a 20-min examiner–child interaction with specified toys, was collected at entry (Week 1) and exit (Week 18) from JASPER + EMT intervention. The NLS was coded for gestures (deictic, conventional, and representational) and gesture–speech combinations (reinforcing, disambiguating, supplementary, other) at entry and spoken language outcomes: speech quantity (rate of speech utterances) and speech quality (number of different words [NDW] and mean length of utterance in words [MLUw]) at exit using European Distributed Corpora Project Linguistic Annotator and Systematic Analysis of Language Transcripts.

Results:

Controlling for nonverbal IQ and autism symptom severity at entry, rate of gesture–speech combinations (but not gestures alone) at entry was a significant predictor of rate of speech utterances and MLUw at exit. The rate of supplementary gesture–speech combinations, in particular, significantly predicted rate of speech utterances and NDW at exit.

Conclusion:

These findings highlight the critical importance of gestural communication, particularly gesture–speech (supplementary) combinations in supporting spoken language development in MV autistic children.
A novel high‐impedance neutral grounding method for medium‐ or large‐size hydroelectric generators
Authors: Jiang Jianming , Jiang Xu , Song Gongyi , Tong Song , Li Yanhai
Published: June 2024

As the capacity of medium or large hydroelectric generators increases, conventional grounding methods face challenges in effectively limiting single‐phase to earth fault current and neutral displacement voltage within acceptable range. Excessive fault current and neutral displacement voltage pose threats to the stability and safety of power generation and transmission systems. Inherent design deficiencies in conventional grounding methods lead to failures in meeting fault current and voltage requirements. To address this, this paper proposes a novel grounding method utilizing high impedance to restrict excessive fault current and neutral displacement voltage. The method minimizes both fault current and neutral displacement voltage by optimally selecting device parameters through minimal iterative trials. Additionally, a novel indicator is introduced to evaluate the effectiveness of grounding method by monitoring changes in neutral displacement voltage. The method is tested through theoretical calculation and field experiments, successfully implemented in large‐size hydroelectric generator.
Life time of Reinforced Concrete floors of industrial buildings, connected with the use of chlorine
Authors: Tamrazyan Ashot G.
Published: June 2024

The article deals with the issues of durability (Life time) of floors of industrial buildings associated with the presence of chlorine. It is shown that, together with carbon dioxide, chlorine forms well-soluble hygroscopic layers in the form of calcium chloride. The movement of chlorine salts causes corrosion of the reinforcement and penetrates deep into the concrete. Therefore, the service life of reinforced concrete elements when exposed to an external aggressive environment is reduced due to corrosion of reinforcement and concrete. Experimental data and analytical dependences of the advance of the front of chloride concentrations dangerous for reinforcement and destruction of concrete under the action of the considered aggressive environment are presented. A formula is derived for the design service life of reinforced concrete structures by the factor of the passivating action of the protective layer of concrete. An empirical dependence of the service life of the structure on the depth of corrosion (diameter reduction) of the reinforcement was also obtained. The coefficient of corrosive wear of reinforcement for rectangular and tee sections bending reinforced concrete elements is calculated.
Formation of sustainable development of investment and construction enterprises based on increasing their mobility
Authors: Khrustalev Boris Borisovich , Kargin Alexey Alexandrovich
Published: June 2024

In market conditions, the effective zone of activity of the investment and construction complex enterprises dramatically changes its boundaries under the influence of the achieved level of their mobility. The object of the research is the organizational and technological processes of the construction of a capital construction facility and the activities of enterprises in conditions of mobility and uncertainty of construction production. The study considers several rational options for increasing the mobility of construction organizations when creating capital construction projects, each one defines the necessary directions for their sustainable development. The use of various mechanisms and digital technologies in the activities of enterprises for their effective management and construction of real estate objects at the stages of the life cycle will increase the stability and reliability of all types of work in conditions of mobility and uncertainties of construction production, carry out and manage all processes that take place at the stages of the life cycle of the object. This will ensure the minimization of negative consequences during the actual implementation of projects at the main stage of the construction of a capital construction facility.
Organizational and legal regulation of labor migration in the Kyrgyz Republic
Authors: Tulegenov Temirlan , Ismanov Taalaybek Kadyrovich , Kulalieva Gulzat Tulegenovna
Published: June 2024

This article discusses the problems of internal migration, territorial population movements, the need for legal regulation and management of migration flows. To reduce the outflow of population from rural areas to cities and the most industrially developed regions. The problems of unregulated labor migration and prospects for coordinating the activities of the state are also considered.
Sources of synergy in the financial and environmental regulation of the state
Authors: Ryspaeva Ainura , Temirov Nazar , Kasymbaeva Nazgul , Chinara Kasymkulova
Published: June 2024

At the present stage of the development of economic science, the identification of synergy in it involves the study of patterns occurring in the production relations of society involving the production of public goods using the productive forces of nature. All this presupposes the formation of some kind of social system of production. Thus, the economy allows humanity to find the most optimal way of its development. All this presupposes the identification of objective patterns in the process of economic development in a particular country as an economy. At the same time, we should not forget that within each individual country, as a separate economy, the same laws operate that are not different from the basic and general laws of the natural sciences, presupposing objective reality itself, despite the fact that each individual country is not without its own particular features of formation, formation and development, taking into account environmental processes.
From Spaces to Societies: Exploring the Impact of Public Interior Design on Urban Social Interactions
Authors: Thi Tam An Nguyen
Published: June 2024

Social interaction is a fundamental human need that involves activities of connection and conversation within urban communities. Previous studies indicated an important approach to enhancing social interactions in urban space to create a livable and sustainable urban community. However, the influences of public interior design on citizen social interactions are underestimated while interior space is where people spend the majority of their time. The primary aim of this paper is to explore the relationship between urban space and interior design and its impact on human social interaction through studies about public interior design. The research method is qualitative and involves studying documents, books, professional magazines, scientific journals, related research projects, and the World Wide Web. The findings of the paper provide a deeper perspective from the standpoint of interior design and underscore the significant responsibilities of interior designers within a larger context, extending beyond the confines of four walls.