bluuebunny/crossref_metadata_2025 huggingface dataset:
Flow‐injection–chemiluminescence method for the determination of penicillin G potassium
Authors: Cao Wei , Yang Jing‐He , Sun Chang‐Xia , Zhang Zhi‐Juang , Gao Qing‐Fei
Published: August 2005

The degradation product of penicillin G potassium can react with potassium permanganate in acidic medium and produce chemiluminescence, which is greatly enhanced by formaldehyde. The optimum conditions for this chemiluminescent reaction were studied in detail using a flow‐injection system. The experiments indicated that under optimum conditions, the chemiluminescence intensity was linearly related to the concentration of penicillin G potassium within the range 1.0 × 10−7–1.0 × 10−5 g/mL, with a detection limit (3σ) of 7 × 10−8 g/mL. The relative standard deviation was 1.0% for 4.0 × 10−7 g/mL penicillin G potassium solution (n = 11). This method has the advantages of simple operation, fast response and high sensitivity. The method was successfully applied to the analysis of penicillin G potassium in raw medicines. Copyright © 2005 John Wiley & Sons, Ltd.
Studies on fluorescence resonance energy transfer between dyes and water‐soluble quantum dots
Authors: Chen Qidan , Ma Qiang , Wan Yi , Su Xingguang , Lin Zhangbi , Jin Qinhan
Published: August 2005

In this work, donor–acceptor complexes were formed based on antibody–antigen interactions. Immunoglobulin antigen (mouse‐IgG) was effectively conjugated to mercaptopropyl acid‐modified CdTe quantum dot synthesized in aqueous solution via electrostatic interaction, while organic dyes–tetramethylrhodamine isothiocyanate (TRITC) were attached to the corresponding antibody (anti‐mouse IgG). The mutual affinity of the antigen and antibody brought the CdTe quantum dot and TRITC sufficiently close together to allow the resonance dipole–dipole coupling required for fluorescence resonance energy transfer to occur. The formation of immunocomplexes resulted in fluorescence resonance energy transfer from the CdTe quantum dot donors to the TRITC acceptors. Copyright © 2005 John Wiley & Sons, Ltd.
The fluorescence sensor for saccharide based on internal conversion
Authors: Sun Xiang‐Ying , Liu Bin
Published: August 2005

In this paper, an internal conversion (IC) fluorescence probe N‐(o‐boronic acid)benzyl‐1‐naphthylamine (BBNA) was prepared from 1‐naphthylamine and 2‐formylbenzeneboronic acid. The fluorescence parameters of BBNA were investigated in a variety of solvents. When BBNA interacted with d‐fructose in phosphate buffer solution of 30% MeOH, pH 8.21 (v/v), the fluorescence intensity increased and emission maximum red‐shifted slightly with increasing d‐fructose concentration. In the presence of d‐fructose, the fluorescence quantum yield of BBNA increased with increasing solvent polarity, suggesting that internal conversion (IC) occurred with BBNA. The binding force of BBNA with d‐fructose was the strongest, and the stability constant (K) of d‐fructose was 99.9 mol/L. Therefore, a selective recognition system based on IC was constructed for d‐fructose. Copyright © 2005 John Wiley & Sons, Ltd.
Application of functional group modified substrate in room temperature phosphorescence, II—heavy atom‐chelated filter paper for selective determination of α‐naphthalene acetic acid
Authors: Zhu Ruohua , Wang Xiangfeng , Wang Pei Long
Published: August 2005

Heavy atom‐chelated filter paper was synthesized and used as the substrate for room‐temperature phosphorescence (RTP). The synthesis conditions for chelated paper were studied. The Pb‐chelated filter paper could selectively induce the RTP of α‐naphthalene acetic acid (α‐NAA). The excitation and emission wavelengths of RTP of α‐NAA were 300 nm and 521 nm, respectively. The concentration of α‐NAA was linear with the RTP intensity in the range 2 × 10−6–6 × 10−4 mol/L (correlation coefficient, 0.9999). The concentration detection limit was 1.35 × 10−7 mol/L and the absolute detection limit was 0.25 ng/spot. The RSD (n = 10) was 1.7%. The method was applied to the analysis of water and vegetable samples with satisfactory results. Because the heavy atom was directly chelated onto the filter paper, the heavy‐atom effect on the RTP of NAA was further increased and the analysis procedure was simple, fast and economical. Copyright © 2005 John Wiley & Sons, Ltd.
A rapid capillary electrophoresis with electrochemiluminescence method for the assay of human urinary proline and hydroxyproline
Authors: Liang Heng , Xue Jing , Li Tian , Wu Yayan
Published: August 2005

A novel simultaneous determination method for free and total proline (Pro) and hydroxyproline (Hyp) in human urine was developed, based on capillary electrophoresis (CE) with electrochemiluminescence (ECL) detection, using tris‐(2,2′‐bipyridyl) ruthenium(II). Experimental conditions, such as the Ru(bpy)32+ concentration, detection potentials, buffer concentration and pH in CE or in the ECL cell, injection voltage and time were investigated in detail. Under optimized conditions, the linear range, detection limit and sample recoveries for the method were 0.01–2 mmol/L (correlation coefficient, 0.9970), 4 µmol/L and 96.4–101.2% in human urine, respectively. The results show that the method has potential applications in monitoring the level of Pro and Hyp in body fluids from patients with bone disease, tumours or chronic uraemia. Copyright © 2005 John Wiley & Sons, Ltd.
Photochemiluminescent detection of antiradical activity. VII. Comparison with a modified method of thermo‐initiated free radical generation with chemiluminescent detection
Authors: Popov I. , Lewin G.
Published: August 2005

The method of photosensitized chemiluminescence (PCL) allows the quantification of water‐ and lipid‐soluble antioxidants and activity of superoxide dismutase (SOD) in the same measuring system. However, it needs a special device, which we have described in a previous paper in this series. Another method suitable for the assay of water‐ and lipid‐soluble antioxidants is the thermo‐initiated decay of azo‐compounds combined with the measurement of O2 consumption (Niki, 1985; Wayner et al., 1985). Its long duration and the complicated measuring procedure is not acceptable for routine medical applications. We show that a modification using CL detection of free radicals with luminol, has results comparable with PCL for the determination of non‐enzymic water‐ and lipid‐soluble antioxidants, SOD activity and oxidative modification of proteins. In contrast to PCL, it is possible to use any luminometer with a heatable measuring cell and to investigate coloured samples. While the new method has an overall higher sensitivity and is scalable to microtitre plates, PCL measurements can be made at different pH. The advantages and analytical information content of certain components of the integral antioxidative capacity of blood plasma are discussed in comparison with other methods. Copyright © 2005 John Wiley & Sons, Ltd.
Proton‐transfer kinetics of photoexcited 7‐hydroxy‐1‐naphthalenesulphonic acid in aqueous DMSO solutions
Authors: Yang Rong , Schulman Stephen G.
Published: August 2005

The monoanion of 7‐hydroxy‐1‐naphthalenesulphonic acid (HNS) undergoes pseudo‐first‐order dissociation and its conjugate base undergoes second‐order protonation in the lowest excited singlet state. The proton transfer kinetics in water containing dimethylsulphoxide (DMSO), up to a mole fraction of about 0.4, have been evaluated as a function of DMSO concentration. At mole fractions above 0.5 of DMSO, proton‐transfer does not measurably occur. At mole fractions below 0.5, steady‐state and pulsed‐source fluorimetries show the rate constant for dissociation to decrease exponentially with increasing mole fraction of DMSO. This is believed to be due to penetration and disruption of the aqueous solvent cage of HNS by DMSO, resulting in impairment of the Grotthus proton‐transfer mechanism. The rate of neutralization of the conjugate base by hydrogen ion is found to vary only slightly with solvent composition and depends on the bulk dielectric properties of the solvent. Copyright © 2005 John Wiley & Sons, Ltd.
A novel chemiluminescence method for the determination of orciprenaline based on ferricyanide‐rhodamine 6G
Authors: Lv Yi , Zhao Rui , Zhu Zhenli , Xu Xianshun , Zhang Xinrong
Published: August 2005

A novel flow injection chemiluminescence method for the determination of orciprenaline was developed. The method is based on the chemiluminescence (CL) reaction of orciprenaline with potassium ferricyanide in sodium hydroxide medium, sensitized by the fluorescent dye rhodamine 6G. The proposed procedure allows quantitation of orciprenaline in the concentration range 0.01–1.2 µg/mL, with a detection limit of 7.2 × 10−3 µg/mL. The relative standard deviation (RSD) is 2.7% for 0.1 µg/mL orciprenaline (n = 9). The sampling frequency was calculated at ∼120/h. The method was successfully applied to the determination of orciprenaline in pharmaceutical preparations. A brief discussion on the possible CL reaction mechanism is presented. Copyright © 2005 John Wiley & Sons, Ltd.
Structural details at active site of hen egg white lysozyme with di‐ and trivalent metal ions
Authors: Li Shu Jie
Published: August 2005

Metal binding to lysozyme has recieved wide interest. In particular, it is interesting that Ni2+, Mn2+, Co2+, and Yb3+ chloride salts induce an increase in the solubility of the tetragonal form in crystals of hen egg white lysozyme at high salt concentration, but that Mg2+ and Ca2+ chloride salts do not. To investigate the interactions of the di‐ and trivalent metal ions with the active site of lysozyme and compare the effects of the di‐ and trivalent metal ions on molecular conformation of lysozyme based on the structural analysis, the crystal structures of hen egg white lysozyme grown at pH 4.6, in the presence of 0.5 M MgCl2, CaCl2, NiCl2, MnCl2, CoCl2, and YbCl3, have been determined by X‐ray crystallography at 1.58 Å resolution. The crystals grown in these salts have an identical space group, P43212. The molecules show no conformational changes, irrespective of the salts used. Ni2+ and Co2+ binding to the Oδ atom of Asp52 in the active site at 1.98 and 2.02 Å, respectively, and Yb3+ binding to both the Oδ atom of Asp52 and the Oδ1 atom of Asn46 at 2.25 Å have been identified. The binding sites of Mn2+, Mg2+, and Ca2+ have not been found from different Fourier electron density maps. The Ni2+ and Co2+ ions bind to the Oδ atom of Asp52 at almost the same position, while the Yb3+ ion takes a different position from the Ni2+ and Co2+ ions. On the other hand, the anion Cl−, interacting with the Oη atom of Tyr23 at a site of about 2.90 Å, has also been determined for each crystal. © 2005 Wiley Periodicals, Inc. Biopolymers 81: 74‐80, 2006

This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Gel‐Type Polyacrylic Resins Cross‐Linked with Trimethylolpropanetrimethacrylate: The Issue of Their Nanostructure and Molecular Accessibility Unveiled with a Combination of Inverse Steric Exclusion Chromatography (ISEC), and ESR and CP‐MAS 13C NMR Spectroscopy
Authors: Pozzar Franco , Sassi Alessandro , Pace Giuseppe , Lora Silvano , D'Archivio Angelo Antonio , Jeřàbek Karel , Grassi Alfonso , Corain Benedetto
Published: August 2005

Six gel‐type functional resins, that is, three poly‐DMAA‐co‐TMPTP (DMAA=N,N‐dimethylacrylamide, TMPTP=trimethylolpropyltrimethacrylate) samples with different degrees of cross‐linking (0.6, 1.2, 1.7 % mol) and three poly‐DMAA‐co‐MA‐co‐TMPTP (MA=methacrylic acid, ca. 5.5 % mol) samples with 1.7, 3.5, and 7 % mol cross‐linking were investigated with ISEC (inverse steric exclusion chromatography), and ESR and CP‐MAS (cross polarization magic angle spinning) 13C NMR spectroscopy after swelling in water and other solvents. This unprecedented combination of conceptually independent physicochemical techniques provides a thorough overall consistent picture of the morphology of the resins on the nanometer scale and of the molecular accessibility of the swollen polymer framework to the paramagnetic probe TEMPONE (2,2,6,6‐tetramethyl‐4‐oxo‐1‐oxypiperidine) and to selected solvents.
A Very Short Uranium—Uranium Bond: The Predicted Metastable U22+.
Authors: Gagliardi Laura , Pyykkoe Pekka , Roos Bjoern O.
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
New Intermetallic Compounds in the Ln—Zn—Al Systems and Their Crystal Structure.
Authors: Stel'makhovych B. , Stel'makhovych O. , Kuz'ma Yu.
Published: August 2005

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Barium Divanadium(V) Tellurite(IV).
Authors: Hou Ju‐Ying , Huang Chang‐Cang , Zhang Han‐Hui , Yang Qi‐Yu , Chen Yi‐Ping , Xu Jian‐Fu
Published: August 2005

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Hexalithium Hexadecahydrate Decavanadate, [Li6(H2O)16V10O28] n.
Authors: Xie Ai‐Li , Ma Chun‐An
Published: August 2005

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A New Look at the nido‐Undecaborate System.
Authors: Volkov Oleg , Radacki Krzystof , Thomas Rhodri Ll. , Rath Nigam P. , Barton Lawrence
Published: August 2005

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Structure and Magnetic Properties of Er3Fe29‐xCrx Compounds.
Authors: Luo H. Z. , Li Y. X. , Jia L. , Meng F. B. , Qu J. P. , Shen J. , Chen N. X. , Wu G. H. , Yang F. M.
Published: August 2005

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Physical Properties Study of Nd2‐xGdxFe17 Intermetallic Alloys.
Authors: Kraiem M. S. Ben , Cheikhrouhou A.
Published: August 2005

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Thermochemistry of a New Class of Materials Containing Dinitrogen Pairs in an Oxide Matrix.
Authors: Tessier Franck , Le Gendre Laurent , Chevire Francois , Marchand Roger , Navrotsky Alexandra
Published: August 2005

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The Quasi‐Ternary System Ag2S—CdS—GeS2 and the Crystal Structure of Ag2CdGeS4.
Authors: Parasyuk O. V. , Piskach L. V. , Olekseyuk I. D. , Pekhnyo V. I.
Published: August 2005

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An Inorganic Nanohybrid with High Specific Surface Area: TiO2‐Pillared MoS2.
Authors: Paek Seung‐Min , Jung Hyun , Park Man , Lee Jin‐Kyu , Choy Jin‐Ho
Published: August 2005

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Two‐Dimensional Organization of [ZnGe3S9(H2O)]4‐ Supertetrahedral Clusters Templated by a Metal Complex.
Authors: Zheng Nanfeng , Bu Xianhui , Feng Pingyun
Published: August 2005

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Long‐Range Magnetic Ordering in Iron Jarosites Prepared by Redox‐Based Hydrothermal Methods.
Authors: Bartlett Bart M. , Nocera Daniel G.
Published: August 2005

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[(Pd—Pd)@Ge18]4‐: A Palladium Dimer Inside the Largest Single‐Cage Deltahedron.
Authors: Goicoechea Jose M. , Sevov Slavi C.
Published: August 2005

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DNA‐Based Asymmetric Catalysis.
Authors: Roelfes Gerard , Feringa Ben L.
Published: August 2005

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Enantioselective Allylation of Aldehydes Catalyzed by Chiral Indium(III) Complexes Immobilized in Ionic Liquids.
Authors: Lu Jun , Ji Shun‐Jun , Loh Teck‐Peng
Published: August 2005

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Enantioselective Conjugate Addition of Diethylzinc to Acyclic Enones Using a Copper Phosphino‐Phenol Complex as Catalyst.
Authors: Ito Katsuji , Eno Shuuichiro , Saito Bunnai , Katsuki Tsutomu
Published: August 2005

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Catalytic Activation of Silylated Nucleophiles Using tBu‐P4 as a Base.
Authors: Ueno Masahiro , Hori Chieko , Suzawa Koichi , Ebisawa Masashi , Kondo Yoshinori
Published: August 2005

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Oxidative Addition of N‐Aminophthalimide to Conjugated and Nonconjugated Alkylazoalkanes.
Authors: Kuznetsov M. A. , Belov V. N. , Buchaka S. M.
Published: August 2005

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Memory of Chirality in Intramolecular Conjugate Addition of Enolates: A Novel Access to Nitrogen Heterocycles with Contiguous Quaternary and Tertiary Stereocenters.
Authors: Kawabata Takeo , Majumdar Swapan , Tsubaki Kazunori , Monguchi Daiki
Published: August 2005

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Development and Comparison of the Substrate Scope of Pd‐Catalysts for the Aerobic Oxidation of Alcohols.
Authors: Schultz Mitchell J. , Hamilton Steven S. , Jensen David R. , Sigman Matthew S.
Published: August 2005

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Silica Chromate as an Oxidizing Agent for the Chemoselective Oxidation of Alcohols and the Oxidative Deprotection of Trimethylsilyl Ethers.
Authors: Zolfigol Mohammad A. , Shirini Farhad , Mohammadpoor‐Baltork Iraj , Choghamarani Arash Gh. , Hajjami Maryam , Sedaghat Abdol M.
Published: August 2005

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A Mild and Efficient Procedure for the Oxidation of Epoxides and Aziridines Using Cerium(IV) Ammonium Nitrate and NBS.
Authors: Surendra K. , Krishnaveni N. Srilakshmi , Rao K. Rama
Published: August 2005

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Transfer Hydrogenation of Activated C=C Bonds Catalyzed by Ruthenium Amido Complexes: Reaction Scope, Limitation, and Enantioselectivity.
Authors: Xue Dong , Chen Ying‐Chun , Cui Xin , Wang Qi‐Wei , Zhu Jin , Deng Jin‐Gen
Published: August 2005

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One‐Pot β‐Substitution of Enones with Alkyl Groups to β‐Alkyl Enones.
Authors: Matsuo Jun‐ichi , Aizawa Yayoi
Published: August 2005

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Nucleophilic Trifluoromethylation of RF‐Containing 4‐Quinolones, 8‐Aza‐ and 1‐Thiochromones with (Trifluoromethyl)trimethylsilane.
Authors: Sosnovskikh Vyacheslav Ya. , Usachev Boris I. , Sevenard Dmitri V. , Roeschenthaler Gerd‐Volker
Published: August 2005

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Ketoacetal Chemistry. Part 1. Reactions of 4,4‐Diethoxy‐2‐trimethylsilyloxy‐1‐butene with Dialdehydes Acetals.
Authors: Kharitonova O. V. , Pisarenko O. N.
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
New Highly Active and Selective Heterogeneous Catalytic System for the Synthesis of Unsymmetrical Organic Carbonates: A Green Protocol.
Authors: Veldurthy Bhaskar , Clacens Jean‐Marc , Figueras Francois
Published: August 2005

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Prototropic Isomerization of Spiro[2,3]hexanes 1,1,5‐Trisubstituted with Electron‐Acceptor Groups into 1,3‐Disubstituted Bicyclo[1.1.0]butanes.
Authors: Razin V. V. , Ulin N. V.
Published: August 2005

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The First Preparation of the α‐Iodo‐β,β‐difluorovinylzinc Reagent (CF2=CIZnCl) and a High‐Yield One‐Pot Synthesis of α‐Iodo‐β,β‐difluorostyrenes.
Authors: Anilkumar R. , Burton Donald J.
Published: August 2005

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Synthesis of gem‐Difluorides from Aldehydes Using DFMBA.
Authors: Furuya Tsukasa , Fukuhara Tsuyoshi , Hara Shoji
Published: August 2005

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Room Temperature Preparation of α‐Chloro‐β,β‐difluoroethenylzinc Reagent (CF2=CClZnCl) by the Metalation of HCFC‐133a (CF3CH2Cl) and a High Yield One‐Pot Synthesis of α‐Chloro‐β,β‐difluorostyrenes.
Authors: Anilkumar R. , Burton Donald J.
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
Preparation of Optically Active α‐Hydroxy Oxime Ether by Diastereoselective Imino 1,2‐Wittig Rearrangement of Hydroximates and Its Application to the Synthesis of (+)‐Cytoxazone.
Authors: Miyata Okiko , Hashimoto Jun , Iba Ryuuichi , Naito Takeaki
Published: August 2005

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Recycling Chiral Organocatalyst (4S)‐Phenoxy‐(S)‐proline for Direct Asymmetric Aldol Reaction in Ionic Liquid (bmim)PF6.
Authors: Liu Yan‐Hua , Zhang Ya‐Wen , Ding Yi‐Ping , Shen Zong‐Xuan , Luo Xiao‐Qing
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
Mannich‐Type Reaction of (1‐Methoxy‐2‐methylpropenyloxy)trimethylsilane with Arylaldehydes and Aromatic Amines Catalyzed by Perfluorinated Rare Earth Metal Salts in Fluorous Phase.
Authors: Shi Min , Cui Shi‐Cong , Liu Ying‐Hao
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
Potassium Trifluoro(organo)borates in Rhodium‐Catalyzed 1,4‐Additions to α,β‐Unsaturated Esters.
Authors: Navarre Laure , Pucheault Mathieu , Darses Sylvain , Genet Jean‐Pierre
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
Efficient, Eco‐Friendly and Regioselective Method for Thiolysis of 1,2‐Epoxides with Diaryl Disulfides in the Presence of Zn/Bi(TFA)3‐TBPB or Zn/Bi(OTf)3‐TBPB.
Authors: Khosropour Ahmad R. , Khodaei Mohammad M. , Ghozati Kazem
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
Activation of Superoxide by Boron Trifluoride: Chemoselective and Efficient Oxidation of Sulfides to Sulfoxides via Tetrafluorodiboronperoxide.
Authors: Chen Yao‐Jung , Shen Jiun‐Yi
Published: August 2005

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An Easy to 7‐Methyl‐2‐naphthalenecarbonitrile.
Authors: Koshio Hiroyuki , Ishihara Tsukasa , Yamada Hiroyoshi , Hirayama Fukushi , Matsumoto Yuzo , Yanagisawa Isao
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
Formation and Skeletal Transformations of Perfluoroindan‐1‐one and Perfluoroindan‐1,3‐dione in the Reaction of Perfluoroindan with SiO2/SbF5.
Authors: Zonov Yaroslav V. , Karpov Victor M. , Platonov Vyacheslav E.
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
2′‐Amino‐α‐chloroacetophenone as a Valuable Tool for the Synthesis of Conveniently‐Substituted α,β‐Epoxychalcone Derivatives.
Authors: Blanc Madeleine , Martin Maud , Okombi Sabrina , Boumendjel Ahcene
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
New Methodology for 2‐Alkylation of 3‐Furoic Acids: Application to the Synthesis of Tethered UC‐781/d4T Bifunctional HIV Reverse‐Transcriptase Inhibitors.
Authors: Arnott Gareth , Hunter Roger , Mbeki Linda , Mohamed Ebrahim
Published: August 2005

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Building up of a peri‐Hydroxynaphthoyl Fragment on the Core of 2H‐Naphtho[1,8‐bc]furan.
Authors: Tyurin R. V. , Antonov A. N. , Minyaeva L. G. , Mezheritskii V. V.
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
Inhibition of IKK‐2 by 2‐[(Aminocarbonyl)amino]‐5‐acetylenyl‐3‐thiophenecarboxamides.
Authors: Bonafoux Dominique , et al. et al.
Published: August 2005

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Intramolecular Hydroamination of Unactived Olefins with Ti(NMe2)4 as a Precatalyst.
Authors: Bexrud Jason A. , Beard J. David , Leitch David C. , Schafer Laurel L.
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
A Practical Synthesis of 3‐Indolyl α,β‐Unsaturated Carbonyl Compounds.
Authors: Wang Weiqi , Ikemoto Tetsuya
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
Simple Synthesis of Dialkyl 2‐(3‐Oxo‐3H‐indol‐2‐yl)‐but‐2‐enedioates.
Authors: Yavari I. , Dehghan Sh. , Alborzi A. R. , Mohtat B.
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
Study on the Reactions of Fluoroalkanesulfonyl Azides with Indole Derivatives.
Authors: He Ping , Zhu Shi‐Zheng
Published: August 2005

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An Efficient Preparation of 1‐Phenylsulfonylindolyl Methyl Sulfoxides Using KF/m‐CPBA.
Authors: Mohanakrishnan Arasambattu K. , Ramesh Neelamegam
Published: August 2005

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A Novel Synthesis of N‐Protected Carbazoles Involving Electrocyclization of in situ Generated Enamines.
Authors: Mohanakrishnan Arasambattu K. , Balamurugan Ramalingam
Published: August 2005

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4‐Functionally‐Substituted 3‐Heterylpyrazoles. Part 15. 3‐Aryl(heteryl)‐1‐phenyl‐4‐pyrazolylmethylamines and Heterocumulenes Obtained Therefrom.
Authors: Bratenko M. K. , Panimarchuk O. I. , Mel'nichenko N. V. , Vovk M. V.
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Biological Activities of 4‐Phenyl‐5‐pyridyl‐1,3‐thiazole Derivatives as p38 MAP Kinase Inhibitors.
Authors: Miwatashi Seiji , Arikawa Yasuyoshi , Naruo Ken‐ichi , Igaki Keiko , Watanabe Yasumasa , Kimura Hiroyuki , Kawamoto Tomohiro , Ohkawa Shigenori
Published: August 2005

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Synthesis of 5‐Amino‐4‐(4‐aryl‐2‐thiazolyl)‐2,3‐dihydro‐2‐pyrrolones.
Authors: Resnyanskaya E. V. , Tverdokhlebov A. V. , Tolmachev A. A. , Volovenko Yu. M.
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
Highly Fluoroalkylated Amphiphilic Triazoles: Regioselective Synthesis and Evaluation of Physicochemical Properties.
Authors: Mayot Estelle , Gerardin‐Charbonnier Christine , Selve Claude
Published: August 2005

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Cycloacylation of N‐Phenyl‐3‐oxobutanethioamide with 3‐Aryl‐2‐propenoyl Chlorides.
Authors: Britsun V. N. , Borisevich A. N. , Samoilenko L. S. , Lozinskii M. O.
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Tricyclic Quinolones and Naphthyridones by Intramolecular Heck Cyclization of Functionalized Electron‐Rich Heterocycles.
Authors: Beccalli Egle M. , Broggini Gianluigi , Martinelli Michela , Paladino Giuseppe , Zoni Caterina
Published: August 2005

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Reduction of Alkyl‐2‐amino‐5,6‐dialkyl‐3‐cyanopyridine‐4‐carboxylates.
Authors: Vasil'ev A. N. , Lyshchikov A. N. , Nasakin O. E. , Kayukov Ya. S. , Tafeenko V. A.
Published: August 2005

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Pyridazine Derivatives and Related Compounds. Part 8. Synthesis of Different Heterocycles from 3‐Hydrazinopyridazine.
Authors: Deeb Ali , Hassaneen Mekky , Kotb Mahmoud
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
Newer Aminopyrimidinimino Isatin Analogues as Non‐Nucleoside HIV‐1 Reverse Transcriptase Inhibitors for HIV and Other Opportunistic Infections of AIDS: Design, Synthesis and Biological Evaluation.
Authors: Sriram D. , Bal T. R. , Yogeeswari P.
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis of Novel Silylated 1,2,4‐Triazin‐5‐ones.
Authors: Bolm Carsten , Kasyan Andrey , Saladin Sandra
Published: August 2005

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Synthesis of Nitroesters Based on Methylol Derivatives of Parabanic and Isocyanuric Acids.
Authors: Ermakov A. S. , Bulatov P. V. , Vinogradov D. B. , Tartakovskii V. A.
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
First Organophosphorus Radical‐Mediated Cyclizations to Afford Medium‐Sized Rings: Eight‐Membered Lactones and Seven‐ and Eight‐Membered Lactams.
Authors: Lang Stuart , Corr Michael , Muir Neil , Khan Tanweer A. , Schoenebeck Franziska , Murphy John A. , Payne Andrew H. , Williams Andrew C.
Published: August 2005

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Study of Nitrogen‐ and Sulfur‐Containing Heterocycles. Part 54. Properties and Conversions of Pyrimido[4,5‐b]‐1,4‐benzothiazepines. Synthesis of a Novel Heterocyclic System: Pyrimido[5,4‐c]isoquinoline.
Authors: Safonova T. S. , Nemeryuk M. P. , Grineva N. A. , Keremov A. F. , Anisimova O. S. , Solov'eva N. P.
Published: August 2005

For Abstract see ChemInform Abstract in Full Text.
Enantiospecific Synthesis of Sesquiterpenes from (R)‐Carvone. Synthesis of 3‐Thapsenol.
Authors: Srikrishna A. , Anebouselvy K.
Published: August 2005

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Three New Cholinesterase‐Inhibiting cis‐Clerodane Diterpenoids from Otostegia limbata.
Authors: Ahmad Viqar Uddin , Khan Afsar , Farooq Umar , Kousar Farzana , Khan Saleha Suleman , Nawaz Sarfraz Ahmad , Abbasi Muhammad Athar , Choudhary Muhammad Iqbal
Published: August 2005

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Synthesis and Estrogenic Activity Screening of Some 6,9‐Disubstituted Estradiol Derivatives.
Authors: Sakac Marija N. , Penov‐Gasi Katarina M. , Popsavin Mirjana , Djurendic Evgenija A. , Andric Silvana , Kovacevic Radmila M.
Published: August 2005

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Selective Synthesis of C‐Arylglycosides via Cp*RuCl‐Catalyzed Partially Intramolecular Cyclotrimerizations of C‐Alkynylglycosides.
Authors: Yamamoto Yoshihiko , Saigoku Tomoaki , Nishiyama Hisao , Ohgai Takashige , Itoh Kenji
Published: August 2005

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1,2‐Anhydrosaccharides and 1,2‐Cyclic Sulfites as Saccharide Donors in Convergent Synthesis of Glucopyranosyl‐, Mannopyranosyl‐ and Ribofuranosylbenzocamalexin.
Authors: Humenik Martin , Kutschy Peter , Kovacik Vladimir , Bekesova Slavka
Published: August 2005

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3‐Substituted Coumarins from the Twigs of Rhadinothamnus rudis ssp. amblycarpus.
Authors: Girard Corinne , Roux Delphine , Muyard Frederic , Colombain Michel , Tillequin Francois , Waterman Peter G. , Bevalot Francoise
Published: August 2005

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An Unusual Nitrogenous Terphenyl Derivative from Fruiting Bodies of the Basidiomycete Sarcodon scabrosus
Authors: Ma Bing‐Ji , Liu Ji‐Kai
Published: August 2005

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One New Prenylated Furanone and Other Non‐Polar Constituents from Mutisia friesiana
Authors: Viturro Carmen I. , de la Fuente Juana R. , Maier Marta S.
Published: August 2005

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Flavonoids from Millettia nitida var. hirsutissima.
Authors: Cheng Jun , Zhao Yu‐Ying , Wang Bin , Qiao Liang , Liang Hong
Published: August 2005

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15‐Amido Erythromycins: Synthesis and in vitro Activity of a New Class of Macrolide Antibiotics.
Authors: Shaw Simon J. , Abbanat Darren , Ashley Gary W. , Bush Karen , Foleno Barbara , Macielag Mark , Zhang Dan , Myles David C.
Published: August 2005

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New Antibiotic Sch 725424 and Its Dehydration Product Sch 725428 from Kitasatospora sp.
Authors: Yang Shu‐Wei , Chan Tze‐Ming , Terracciano Joseph , Patel Reena , Loebenberg David , Chen Guodong , Patel Mahesh , Gullo Vincent , Pramanik Birendra , Chu Min
Published: August 2005

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Absolute Stereostructures of Cell‐Adhesion Inhibitors, Peribysins A, E, F and G, Produced by a Sea Hare‐Derived Periconia sp.
Authors: Yamada Takeshi , Doi Misunobu , Miura Atsuko , Harada Waka , Hiramura Mika , Minoura Katsuhiko , Tanaka Reiko , Numata Atsushi
Published: August 2005

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Inhibitors of Nitric Oxide Production from the Flowers of Angelica furcijuga: Structures of Hyuganosides IV and V.
Authors: Matsuda Hisashi , Morikawa Toshio , Ohgushi Teruki , Ishiwada Tomoko , Nishida Norihisa , Yoshikawa Masayuki
Published: August 2005

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The Evaluation of 2,8‐Disubstituted Benzoxazinone Derivatives as Antiinflammatory and Antiplatelet Aggregation Agents.
Authors: Hsieh Pei‐Wen , Hwang Tsong‐Long , Wu Chin‐Chung , Chang Fang‐Rong , Wang Tsai‐Wei , Wu Yang‐Chang
Published: August 2005

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Fully Accessible Ag Nanoparticles within Three‐Dimensionally Ordered Macroporous SiO2.
Authors: Wu Quan‐Zhou , Yin Qiang , Liao Ju‐Fang , Deng Jing‐Heng , Li Yu‐Guang
Published: August 2005

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Structures and Properties of Nanometer Size Materials. Part 3. Structures and Physical Properties of Iron Nanoparticles.
Authors: Li Xiao‐Hua , Ma Mei‐Hua , Huang Jin‐Fan
Published: August 2005

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Thermodynamics of the LiOH + H2O System
Authors: Monnin Christophe , Dubois Michel
Published: August 2005

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Underpotential Deposition of Metals — Progress and Prospects in Modeling
Authors: Sudha V. , Sangaranarayanan M. V.
Published: August 2005

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Scanning Micro‐ and Nanoprobes for Electrochemical Imaging
Authors: Kranz C. , Kueng A. , Mizaikoff B.
Published: August 2005

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1,1′‐Di(heteroatom)‐Functionalized Ferrocenes as [N,N], [O,O] and [S,S] Chelate Ligands in Transition Metal Chemistry
Authors: Siemeling Ulrich , Auch Tanja‐Corinna
Published: August 2005

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2‐Iodoxybenzoic Acid (IBX): A Versatile Reagent
Authors: Kumar Indresh
Published: August 2005

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Nitrenium Ions and Problem of Direct Electrophilic Amination of Aromatic Compounds
Authors: Borodkin G. I. , Shubin V. G.
Published: August 2005

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Epoxide Hydrolases: Mechanisms, Inhibitor Designs, and Biological Roles
Authors: Morisseau Christophe , Hammock Bruce D.
Published: August 2005

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Elemental Fluorine and HOF×CH3CN in Service of General Organic Chemistry
Authors: Rozen Shlomo
Published: August 2005

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Synthesis and Reactions of 2‐Substituted Quinolines and Their Vinylogues
Authors: Zemtsova M. N. , Zimichev A. V. , Trakhtenberg P. L.
Published: August 2005

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Fast, Easy, Clean Chemistry by Using Water as a Solvent and Microwave Heating: The Suzuki Coupling as an Illustration.
Authors: Leadbeater Nicholas E.
Published: August 2005

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2‐Pyrone Natural Products and Mimetics: Isolation, Characterization and Biological Activity
Authors: McGlacken Gerard P. , Fairlamb Ian J. S.
Published: August 2005

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Protein Glycosylation: New Challenges and Opportunities
Authors: Wong Chi‐Huey
Published: August 2005

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Metallacyclopeptides: Artificial Analogues of Naturally Occurring Peptides
Authors: Albrecht Markus , Stortz Patrick
Published: August 2005

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1,3‐Dipolar Cycloaddition on Solid Supports: Nitrone Approach Towards Isoxazolidines and Isoxazolines and Subsequent Transformations
Authors: Rueck‐Braun Karola , Freysoldt Tonia H. E. , Wierschem Frank
Published: August 2005

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Chemistry and Biology of Wortmannin
Authors: Wipf Peter , Halter Robert J.
Published: August 2005

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Recent Synthesis and Transformation of Vinylphosphonates
Authors: Dembitsky Valery M. , Quntar Abed Al Aziz , Haj‐Yehia Abdullah , Srebnik Morris
Published: August 2005

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C‐Alkoxycarbonyl Nitrones: Building Blocks for the Synthesis of Butenolides, Lactams and Modified Nucleosides
Authors: Romeo G. , Iannazzo D. , Piperno A. , Romeo R. , Corsaro A. , Rescifina A. , Chiacchio U.
Published: August 2005

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Isomerization of Organic Substrates Catalyzed by Ruthenium Complexes
Authors: Suzuki Hiroharu , Takao Toshiro
Published: August 2005

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Nucleophilic Additions to Alkynes and Reactions via Vinylidene Intermediates
Authors: Fischmeister C. , Bruneau C. , Dixneuf P. H.
Published: August 2005

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Bimetallic Transition Metal Catalysts for Organic Oxidation
Authors: Henry Patrick M.
Published: August 2005

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Catalytic and Stoichiometric Transformations by Multimetallic Rare Earth Metal Complexes
Authors: Hou Zhaomin
Published: August 2005

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Rare Earth‐Alkali Metal Heterobimetallic Asymmetric Catalysis
Authors: Matsunaga Shigeki , Shibasaki Masakatsu
Published: August 2005

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Soluble Polymers as Catalyst and Reagent Platforms: Liquid‐Phase Methodologies
Authors: Dickerson Tobin J. , Reed Neal N. , Janda Kim D.
Published: August 2005

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Organic Synthesis on Polymeric Supports
Authors: Gil Carmen , Knepper Kerstin , Braese Stefan
Published: August 2005

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Nitrous Oxide in Oxidation Chemistry and Catalysis: Application and Production
Authors: Parmon V. N. , Panov G. I. , Uriarte A. , Noskov A. S.
Published: August 2005

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Inductors with High L and Q: Polymeric Magnetics
Authors: Watson Corinne , Masi James V.
Published: August 2005

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Phase Equilibria of Ethanol Fuel Blends
Authors: French Raymond , Malone Patrick
Published: August 2005

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Chemical Genetics to Chemical Genomics: Small Molecules Offer Big Insights
Authors: Spring David R.
Published: August 2005

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Phosphoryl Transfer Enzymes and Hypervalent Phosphorus Chemistry: A Keynote Lecture of the 7th International Conference on Heteroatom Chemistry
Authors: Holmes Robert R.
Published: August 2005

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Hsp27 Consolidates Intracellular Redox Homeostasis by Upholding Glutathione in Its Reduced Form and by Decreasing Iron Intracellular Levels
Authors: Arrigo Andre‐Patrick , Virot Sophie , Chaufour Sylvain , Firdaus Wance , Kretz‐Remy Carole , Diaz‐Latoud Chantal
Published: August 2005

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Physicochemical Perspectives on DNA Microarray and Biosensor Technologies
Authors: Levicky Rastislav , Horgan Adrian
Published: August 2005

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2004 Fred Beamish Award Lecture — Analytical — Materials Chemistry on Old CDs — Beyond Self‐Assembly
Authors: Ho Casssie , Soolaman Dinah M. , Yu Hua‐Zhong
Published: August 2005

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Free Energy Surfaces from Single‐Molecule Force Spectroscopy
Authors: Hummer Gerhard , Szabo Attila
Published: August 2005

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Exploring Supramolecular Interactions and Architectures by Scanning Force Microscopies
Authors: Samori Paolo
Published: August 2005

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Rituximab therapy is effective for posttransplant lymphoproliferative disorders after solid organ transplantation
Authors: Blaes Anne H. , Peterson Bruce A. , Bartlett Nancy , Dunn David L. , Morrison Vicki A.
Published: September 2005

BACKGROUND

Posttransplant lymphoproliferative disorders (PTLD) remain an uncommon complication of solid organ transplantation with a high mortality rate reported after conventional therapies. Alternative treatments such as rituximab have been explored.

METHODS

Eleven patients with PTLD, who were CD20 positive, received an intravenous dose of rituximab, 375 mg/m2, weekly × 4 weeks, repeated every 6 months for 2 years in responding patients. The median age of the patients was 56 years (range, 43–68 yrs), and 9 patients were male. The type of solid organ transplantation that these patients received included lung (five patients), kidney (four patients), heart (one patient), and kidney/pancreas (one patient). The median time from transplantation to a PTLD diagnosis was 9 months (range, 1–122 mos). Diagnostic B‐cell histology was diffuse large cell lymphoma or polymorphous process. No patient had bone marrow or central nervous system involvement. Primary extranodal disease was noted in 82% of patients. Immunosuppressive therapy was decreased at the time of diagnosis.

RESULTS

Rituximab was well tolerated, with mild infusional blood pressure alterations noted in two patients. The median follow‐up period was 10 months (range, 1–32 mos). The overall response rate was 64%, with 6 complete responses (CR), 1 partial response, 2 cases of progressive disease, and 2 deaths. The median duration of CR was 8 months (range, 2–19+ mos). The median time to treatment failure was 10 months (range, 5–25+ mos). The median survival was 14 months (range, < 1–32+ mos). Four patients were alive at the time of last follow‐up.

CONCLUSIONS

Single‐agent rituximab may offer a response and survival advantage in patients with PTLD. Further evaluation of rituximab in these disorders, potentially in combination with other therapies, is warranted. Cancer 2005. © 2005 American Cancer Society.
The epigenome as a molecular marker and target
Authors: Gius David , Bradbury C. Matthew , Sun Lunching , Awwad Rania T. , Huang Lei , Smart Dee Dee K. , Bisht Kheem S. , Ho Allen S. , Nguyen Phuongmai
Published: September 2005

Tumor cell proliferation, de‐differentiation, and progression depend on a complex combination of altered cell cycle regulation, excessive growth factor pathway activation, and decreased apoptosis. The understanding of these complex mechanisms should lead to the identification of potential molecular markers, targets, and molecular profiles that should eventually expand and improve therapeutic intervention.

It now appears clear that methylation plays a central role in transformation, both in vitro and in vivo. However, the exact targets and mechanism(s) are not yet fully understood. This is partly due to the significant number of genes altered by changes in intracellular methyltransferase activity and the chemical agents used to modulate gene expression. The complex nature of methylation's role in regulating gene expression suggests that in addition to investigating individual genes, researchers should develop more comprehensive methods to examine gene expression patterns and their predictive value as this will likely be necessary in the future.

If methylation plays a role in transformation, then it seems logical that genes regulating intracellular methylation status may be used as molecular markers to profile tumors by any new methods currently being developed. Perhaps more noteworthy is that DNMT genes may be found to be novel molecular targets for new factor‐specific anticancer agents. This idea will be addressed. Cancer 2005. Published 2005 by the American Cancer Society.
Octahedral Hexahydroxo Rhenium Cluster Complexes [Re6Q8(OH)6]4–·(Q = S, Se): Synthesis, Structure, and Properties
Authors: Yarovoi Spartak S. , Mironov Yuri V. , Naumov Dmitry Y. , Gatilov Yuri V. , Kozlova Svetlana G. , Kim Sung‐Jin , Fedorov Vladimir E.
Published: August 2005

Two novel rhenium cluster compounds, K4[Re6S8(OH)6]·8H2O (1) and K4[Re6Se8(OH)6]·8H2O (2), containing octahedral cluster chalcogenide anionic complexes [Re6Q8(OH)6]4– with terminal hydroxo ligands have been synthesized by the reaction of Re6Q8Br2 (Q = S, Se) with molten KOH. Two chalcohalide compounds, one known (Cs4[Re6S8Br6]·2H2O, 3) and another new (Cs3[Re6Se8Cl6]·2H2O, 4), were prepared by reactions of 1 and 2 with CsX and HX (X = Br, Cl) in an aqueous solution. Compounds 1, 2, and 4 have been characterized by the single‐crystal X‐ray diffraction method. Compounds 1 and 2 are crystallized in triclinic space group P$\bar {1}$ with one formula unit in the cell of dimensions a = 8.4936(8) Å, b = 8.9101(11) Å, c = 10.5940(13) Å, α = 77.935(11)°, β = 75.933(9)°, γ = 71.244(10)°, V = 728.9(1) Å3 (compound 1) and a = 8.613(1) Å, b = 8.996(1) Å, c = 10.057(1) Å, α = 78.587(2)°, β = 77.811(2)°, γ = 71.728(2)°, V = 715.9(2) Å3 (compound 2). Compound 4 crystallizes in the monoclinic space group P21/n with two formula units in the cell of dimensions a = 9.819(3) Å, b = 12.925(4) Å, c = 11.756(4) Å, β = 113.38(3)°, V = 1369.6(8) Å3. Compounds 1 and 2 display luminescent properties. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Synthesis, Structure, and Properties of Zirconium and Hafnium Complexes Containing η2‐Pyrazolato Ligands
Authors: Sebe Elena , Guzei Ilia A. , Heeg Mary Jane , Liable‐Sands Louise M. , Rheingold Arnold L. , Winter Charles H.
Published: August 2005

Treatment of tetrakis(dimethylamido)zirconium with four equiv. of 3,5‐dimethylpyrazole, 3,5‐di‐tert‐butylpyrazole, or 3,5‐diphenylpyrazole in refluxing toluene afforded tetrakis(η2‐3,5‐dimethylpyrazolato)zirconium (86 %), tetrakis(η2‐3,5‐di‐tert‐butylpyrazolato)zirconium (88 %), and tetrakis(η2‐3,5‐diphenylpyrazolato)zirconium (85 %), respectively, as colorless crystalline solids. The analogous hafnium complexes were prepared through treatment of hafnium tetrachloride with four equiv. of the potassium salts of 3,5‐dimethylpyrazolate, 3,5‐di‐tert‐butylpyrazolate, or 3,5‐diphenylpyrazolate in tetrahydrofuran to afford tetrakis(η2‐3,5‐dimethylpyrazolato)hafnium (75 %), tetrakis(η2‐3,5‐di‐tert‐butylpyrazolato)hafnium (58 %), and tetrakis(η2‐3,5‐diphenylpyrazolato)hafnium·toluene (38 %), respectively, as colorless crystalline solids. X‐ray crystal structures of representative members of these complexes revealed monomeric species containing four η2‐pyrazolato ligands and approximate dodecahedral geometry about the metal centers. Treatment of tetrakis(η2‐3,5‐dimethylpyrazolato)hafnium with 3,5‐dimethylpyrazole in a 1:1 molar ratio afforded tris(η2‐3,5‐dimethylpyrazolato)(η1‐3,5‐dimethylpyrazolato)(η1‐3,5‐dimethylpyrazole)hafnium as colorless crystals (84 %). Tris(η2‐3,5‐dimethylpyrazolato)(η1‐3,5‐dimethylpyrazolato)(η1‐3,5‐dimethylpyrazole)hafnium contains three η2‐3,5‐dimethylpyrazolato, one η1‐3,5‐dimethylpyrazolato, and one η1‐3,5‐dimethylpyrazole ligands. The η1‐3,5‐dimethylpyrazolato and η1‐3,5‐dimethylpyrazole ligands are connected through a N–H···N hydrogen bond. Tetrakis(η2‐3,5‐dimethylpyrazolato)hafnium did not form an adduct with pyridine or tetrahydrofuran, suggesting that the formation of a hydrogen bond is important to the stability of adducts. Attempted sublimation of all of the new pyrazolato complexes led to some decomposition, as evidenced by the formation of the free pyrazoles in the sublimates and significant amounts of nonvolatile residues. This work greatly expands the number of zirconium and hafnium complexes that contain η2‐pyrazolato ligands. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
Use of Tin (IV) Porhyrins as Ionophores for the Construction of Phthalate‐Selective Electrodes: Influence of the Structure and Membrane Composition on their Response Properties
Authors: Santos Emília M. G. , Araújo Alberto N. , Couto Cristina M. C. M. , Montenegro M. Conceição B. S. M.
Published: August 2005

Tin(IV) porphyrins derivatives were used as ionophores for phthalate selective electrodes preparation. The influence of ionophore structure and membrane composition (amount of incorporated ionic sites) on the electrode response, selectivity and long‐term stability were studied. Poly(vinyl chloride) polymeric membranes plasticized with o‐NPOE (o‐nitrophenyloctylether) and containing Sn(IV)‐tetraphenylporphyrin (TPP) dichloride (Sn(IV)[TPP]Cl2) or Sn(IV)‐octaethylporphyrin (OEP) dichloride (Sn(IV)[OEP]Cl2), and in some cases incorporating lipophilic cationic (tetraocthylammonium bromide ‐ TOABr) and anionic (sodium tetraphenylborate – NaTPB and potassium tetrakis[3,5‐bis(trifluoromethyl)phenyl]borate‐KTFPB) additives, were prepared and their potentiometric characteristics compared. Both ionophores are shown to operate via a neutral mechanism, and the addition of 10 mol % of lipophilic quaternary ammonium salt derivative to the membrane is required to achieve optimal electrode performance. The potentiometric units prepared, with Sn(IV)[TPP]Cl2 (Type A) or Sn(IV)[OEP]Cl2 (Type B) without additives, presented a slope of −52.8 mV dec−1 and −58.8 mV dec−1 and LLLR of 9.9×10−5 mol L−1 and 9.9×10−6 mol L−1, respectively. The units prepared using the same metalloporphyrins and incorporating 10% mol TOABr presented a slope of −55.0 mV dec−1 and −57.8 mV dec−1 and LLLR of 5.0×10−7 mol L−1 and 3.0×10−7 mol L−1. Their analytical usefulness was assessed by potentiometric determinations of phthalate in water and industrial products providing results that presented recoveries of about 100%.