bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrative Analysis Reveals the Potential Role and Prognostic Value of GOLM1 in Hepatocellular Carcinoma
Authors: Lin Yan , He Ziqin , Gao Xing , Lu Lu , Lu Cheng , Huang Julu , Luo Min , Ye Jiazhou , Liang Rong
Published: September 2022

Overexpression of Golgi membrane protein 1 (GOLM1) is closely associated with hepatocellular carcinoma (HCC) vascular invasion. How GOLM1 may be involved in angiogenesis in HCC remains unclear. We explored how GOLM1 promotes angiogenesis in HCC and potential prognostic value. Expression levels of GOLM1 in HCC patients and healthy controls were obtained from The Cancer Genome Atlas (TCGA). Differentially expressed genes (DEGs) between HCC patients and controls were compared. GOLM1 was knocked out in the HCC cell line, and RNA sequencing and DEG expression analysis were performed compared with control cells. Based on TCGA data and cell line RNA sequencing data, DEGs affected by a high expression of GOLM1 were identified. Subsequently, enrichment analysis was performed to explore the functions and pathways of the DEGs affected by a high expression of GOLM1. A relevant network analysis was built. Cox regression, genomic variance analysis scores, minimum absolute shrinkage and selection operator regression, and random forest regression models were applied to determine the best prognostic model and validated using the GSE54236 dataset from the Gene Expression Omnibus (GEO). We determined the effect of GOLM1 expression on immune cell infiltration in liver cancer. GOLM1 was overexpressed in HCC tissues compared with controls, and its level correlated with tumor purity and prognosis. 400 DEGs affected by highly expressed GOLM1 were identified in TCGA and cell line RNA sequencing data. Enrichment analysis revealed that these DEGs may be related to biological processes of oxidative stress and angiogenesis and involved in the VEGF signaling pathway and protein processing in endoplasmic reticulum. We predicted a comprehensive regulatory network in which GOLM1 activated VEGF signaling to promote HCC angiogenesis. GOLM1 may interact with E2F1 and IGF2BP3 to promote angiogenesis. GOLM1 overexpression was associated with greater immune cell infiltration. A random forest regression model was the best prognostic model. Our study reveals a potential molecular mechanism of GOLM1 in promoting HCC. We developed two prognostic models based on DEG associated with GOLM1 overexpression to help stratify HCC prognosis and improve individualized treatment.
Research on Fitting Algorithm of Scattered Point Cloud Based on 3D Laser Scanning
Authors: Jiang Tianen , Lin Xiaojun , Fang Liang , Yao Tianyu , Zhao Yuzhen , Wei Zheng
Published: September 2022

3D laser scanning equipment is an important equipment for reverse engineering. It is used as an information sensing device for the Industrial IoT. After analyzing and processing the measured data, it can issue construction instructions to equipment such as TBMs and shotcrete manipulator. It can be used to solve the problems of initial support contour detection, flatness detection, monitoring measurement, and so on in tunnel engineering. This paper considers that 3D laser scanning point cloud is a scattered point cloud and cannot be used directly. In order to extract the point cloud information as much as possible, it is necessary to fit the point cloud obtained by scanning first. This paper uses the triangulation method, the Poisson reconstruction method, and the Lagrange method, etc. to fit the scattered point cloud, analyzes the advantages and disadvantages of several fitting methods, and analyzes the accuracy of the surfaces generated by several fitting methods. This creates conditions for the subsequent utilization of the tunnel 3D laser scanning point cloud.
Relationship between Urban Innovation Capability and Energy Utilization Efficiency: An Empirical Study of 281 Prefecture‐Level Cities in China
Authors: Wu Wanshu , Zhao Kai
Published: September 2022

Following a dynamic nonlinear perspective, this study explores the relationship between urban innovation capability and energy utilization efficiency by employing the Panel Vector Autoregression (PVAR) and Dynamic Panel Threshold Regression (DPTR) methods. Using the 2003–2020 panel data of 281 prefecture‐level cities in China, this study confirms that energy utilization efficiency improves owing to the improvement of urban innovation capability. Depending on the characteristics of the city, such as population density, industrial structure, and environmental pollution, high energy utilization efficiency in the early stages of city development may help or hinder the improvement of energy utilization efficiency in the later stages. The enhancement in urban innovation capability has failed to improve energy utilization efficiency and has adversely affected cities with a low population density or weak secondary industrial foundation. However, in cities with a high population density or proportion of secondary industry, the improvement in innovation capability significantly increases the efficiency of energy utilization. In addition, the positive effect that urban innovation capability has on energy utilization efficiency is higher in low‐pollution cities than in high‐pollution cities.
Modeling Drug Concentration Level in Blood Using Fractional Differential Equation Based on Psi‐Caputo Derivative
Authors: Awadalla Muath , Noupoue Yves Yannick Yameni , Asbeh Kinda Abu , Ghiloufi Noureddine
Published: September 2022

This article studies a pharmacokinetics problem, which is the mathematical modeling of a drug concentration variation in human blood, starting from the injection time. Theories and applications of fractional calculus are the main tools through which we establish main results. The psi‐Caputo fractional derivative plays a substantial role in the study. We prove the existence and uniqueness of the solution to the problem using the psi‐Caputo fractional derivative. The application of the theoretical results on two data sets shows the following results. For the first data set, a psi‐Caputo with the kernel ψ = x + 1 is the best approach as it yields a mean square error (MSE) of 0.04065. The second best is the simple fractional method whose MSE is 0.05814; finally, the classical approach is in the third position with an MSE of 0.07299. For the second data set, a psi‐Caputo with the kernel ψ = x + 1 is the best approach as it yields an MSE of 0.03482. The second best is the simple fractional method whose MSE is 0.04116 and, finally, the classical approach with an MSE of 0.048640.
[Retracted] Effect of Radioimmunoassay on Accuracy of Thyroid Hormone Detection
Authors: Wu Zhixiang
Published: September 2022

At present, the most important method for the detection of thyroid hormones in hospitals in China is radioimmunoassay. Besides radioimmunoassay, there are blood test and antibody test methods for thyroid hormone detection. However, after long‐term clinical investigations, the accuracy of the results of thyroid hormone detection by radioimmunoassay has been affected by many factors. Possible influencing factors include inaccurate thyroid hormone test results due to improper way of blood collection by nurses and improper way of keeping and transporting blood samples by nurses. Therefore, this paper analyzes and discusses the influencing factors of the accuracy of thyroid hormone (T4) detection by radioimmunoassay technology. In this paper, we conducted research using statistical analysis of clinical data, improved separation methods for quality control in the laboratory, and blood specimen collection methods. Radioimmunoassay occurs with antibodies. Of the 10 batches of 964 cases in the improved separation methods for quality control in the laboratory, 154 mismatched items accounted for 16%, and the error of method and operation only accounted for 5.8% of unmatched specimens, most of which were the biochemical characteristics and clinical manifestations of thyroid hormones. The blood sample collection method research found that mild hemolysis had no significant effect on the measurement results, severe hemolysis had a tendency to affect the results, and blood collection tubes had no effect on the test results. Mild hemolysis refers to the increase in the rate of red blood cell destruction due to various internal and external factors in the body. The symptoms when mild hemolysis occurs are generally not obvious. Severe hemolysis refers to a disease caused by blood group incompatibility, mainly referring to immune hemolysis caused by blood group incompatibility between mother and baby, as well as severe jaundice or severe anemia. The statistical analysis of clinical data found that, among 160 patients, the reasons for the inaccuracy of T4 results using radioimmunoassay technology were as follows: 104 patients were inaccurate due to personal factors, and the results were due to hospital factors. A total of 56 patients had inaccurate results. During the measurement of thyroid hormone, it will be affected by many factors. For this reason, the influencing factors of the accuracy of radioimmunoassay should be clarified, and appropriate measures should be taken to deal with it, so as to give full play to the role of radioimmunoassay and improve the detection.
Analysis of the Incidence and Risk Factors of Precocious Puberty in Girls during the COVID-19 Pandemic
Authors: Fu Dongxia , Li Tao , Zhang Yingxian , Wang Huizhen , Wu Xue , Chen Yongxing , Cao Bingyan , Wei Haiyan
Published: September 2022

Home quarantine due to the global coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on children. Lifestyle changes have led to an increase in precocious puberty (PP) among girls, and the underlying risk factors for this remain unclear. Thus, we aimed to assess the influence of environmental, genetic, nutritional, and other lifestyle factors on the risk of PP in girls. We evaluated the incidence of new-onset PP in girls during home quarantine for COVID-19 and analyzed the potential risk factors. This was a retrospective questionnaire and medical record-based study involving 22 representative medical units from 13 cities in Henan Province, China. Girls with new-onset PP (central precocious puberty, 58; premature thelarche, 58; age, 5–9 years) between February 2020 and May 2020 were included, along with 124 healthy, age-matched controls. The number of new-onset PP cases reported during the study period was compared with that reported between February and May in 2018 and 2019. Patients’ families completed a questionnaire to assess potential risk factors. There was a 5.01- and 3.14-fold increase in the number of new-onset PP cases from 2018 to 2020 and from 2019 to 2020, respectively; the differences were statistically significant (

p
<
0.01

). High-risk factors for PP included longer time spent using electronic devices, decreased exercise time, higher body mass index, vitamin D deficiency, young age (<12 years) of mother during menarche, consumption of fried food and processed meat, residence in rural areas, and consumption of off-season fruits. Thus, we found that lifestyle changes caused due to the COVID-19 pandemic led to a significant increase in PP in girls. Management of the risk factors identified in this study may help in PP prevention.
Computer-Aided Analysis of Small Clear Space Intersection Tunnel and Heavy Load Railway Surrounding Rock Structure Dynamic Response Characteristics Analysis under Intelligent Manufacturing
Authors: Hao Xiaotian , Wang Hailong
Published: September 2022

Among many tunnel construction projects, small clear tunnels have been the focus of urban rail transit construction in recent years. The purpose of this research work is to study the dynamic response characteristics of the surrounding rock structure of a heavy-duty railway with a small clearance crossing tunnel. It is proposed to analyze the dynamic response characteristics of the surrounding rock structure through the frequency response function. The vertical acceleration, tensile force, stress, and internal strength of the pipe section are specifically analyzed. The influence of the pipe joint and the assembly method on the dynamic response is also analyzed. The influencing factors of stability are analyzed from buried depth, clear distance, and surrounding rock grade. Studies have shown that the minimum clear distance of crossing tunnels increases nonlinearly with the increase of tunnel depth and gravity, and decreases nonlinearly with the increase of cohesion, internal friction angle, calculated internal friction angle, and lateral pressure coefficient. When other parameters are the same and when the side pressure coefficient is less than 1, the minimum clear distance is larger than that of the side pressure coefficient when it is equal to 1. When the vibration frequency exceeds 100 Hz, the coherence coefficient is basically close to 1, indicating that the frequency response function response result of this section is the most reliable. It is hoped that it can provide a reference for the dynamic stability analysis of the surrounding rock structure of the heavy-duty railway surrounding rock structure and the surrounding stratum and the research of structural vibration reduction technology for the small clearance crossing tunnel in the future.
The Magnitude of Hidden Hunger and Cognitive Deficits among Children Living in Orphanages in Kumasi, Ghana
Authors: Tandoh Marina , Asamoah Mary
Published: September 2022

This study assessed the magnitude of hidden hunger (micronutrient deficiencies) and cognitive deficits of 130 school-aged children (6–13 years old) living in three selected orphanages in Kumasi, Ghana. Sociodemographic data assessment, anthropometric assessment (BMI for age and height for age), dietary assessment (3-day repeated 24-hour dietary recall), urinary iodine level assessment, and cognitive performance assessment (Raven’s Coloured Progressive Matrices) were performed. Boys formed 50.8% of the study population, while girls formed 49.2%. The median age of participants was 10.50 years. About 12.3%, 7%, and 10.0% of participants were stunted, thin, and overweight/obese, respectively. The prevalence of mild iodine deficiency (i.e., 50–99 μg/L) was 16.2%. Iodine deficiency was significantly higher (23.6%) in participants who had lived for at least 7 years in the orphanage compared to those who had lived less than 7 years (10.7%) (

p
=
0.047

). About 17% of the participants performed poorly (<50%) on the cognition test. Mean cognition test scores were significantly different among the orphanages (

p
=
0.027

). The majority of participants, 89.2%, 54.6%, 76.9%, and 77.7%, had adequate intake of iron, zinc, vitamin C, and folate, respectively, whereas intake of vitamins A and B12 was inadequate for the majority of participants (90.8% and 50.8%, respectively). There was no significant correlation between micronutrient intake and cognitive performance. However, mean cognition test scores were significantly different between participants with adequate and inadequate iron and vitamin A intake (

p
=
0.007

and

p
<
0.001

, respectively). The findings of this study warrant a closer look at nutritional intakes in orphanages to improve hidden hunger and cognitive performance.
Doxorubicin-Loaded Polymeric Meshes Prevent Local Recurrence after Sarcoma Resection While Avoiding Cardiotoxicity
Authors: Bressler Eric M. , Chu Ngoc-Quynh , Sabatelle Robert C. , Mahvi David A. , Korunes-Miller Jenny T. , Nagashima Fumiaki , Ichinose Fumito , Liu Rong , Grinstaff Mark W. , Colson Yolonda L. , Raut Chandrajit P.
Published: September 2022

Surgery is the only potentially curative treatment for localized soft-tissue sarcomas. However, for sarcomas arising in the retroperitoneum, locoregional recurrence rates are 35% to 59% despite resection. Doxorubicin (DOX) is the standard first-line systemic chemotherapy for advanced soft-tissue sarcoma, yet its intravenous administration yields limited clinical efficacy and results in dose-limiting cardiotoxicity. We report the fabrication and optimization of a novel electrospun poly(caprolactone) (PCL) surgical mesh coated with layers of a hydrophobic polymer (poly(glycerol monostearate-co-caprolactone), PGC-C18), which delivers DOX directly to the operative bed following sarcoma resection. In xenograft models of liposarcoma and chondrosarcoma, DOX-loaded meshes (DoM) increased overall survival 4-fold compared with systemically administered DOX and prevented local recurrence in all but one animal. Importantly, mice implanted with DoMs exhibited preserved cardiac function, whereas mice receiving an equivalent dose systemically displayed a 23% decrease from baseline in both cardiac output and ejection fraction 20 days after administration. Collectively, this work demonstrates a feasible therapeutic approach to simultaneously prevent post-surgical tumor recurrence and minimize cardiotoxicity in soft-tissue sarcoma.

Significance:

A proof-of-principle study in animal models shows that a novel local drug delivery approach can prevent tumor recurrence as well as drug-related adverse events following surgical resection of soft-tissue sarcomas.
Modeling Preclinical Cancer Studies under Physioxia to Enhance Clinical Translation
Authors: Adebayo Adedeji K. , Nakshatri Harikrishna
Published: September 2022

Oxygen (O2) plays a key role in cellular homeostasis. O2 levels are tightly regulated in vivo such that each tissue receives an optimal amount to maintain physiologic status. Physiologic O2 levels in various organs range between 2% and 9% in vivo, with the highest levels of 9% in the kidneys and the lowest of 0.5% in parts of the brain. This physiologic range of O2 tensions is disrupted in pathologic conditions such as cancer, where it can reach as low as 0.5%. Regardless of the state, O2 tension in vivo is maintained at significantly lower levels than ambient O2, which is approximately 21%. Yet, routine in vitro cellular manipulations are carried out in ambient air, regardless of whether or not they are eventually transferred to hypoxic conditions for subsequent studies. Even brief exposure of hematopoietic stem cells to ambient air can cause detrimental effects through a mechanism termed extraphysiologic oxygen shock/stress (EPHOSS), leading to reduced engraftment capabilities. Here, we provide an overview of the effects of ambient air exposure on stem and non-stem cell subtypes, with a focus on recent findings that reveal the impact of EPHOSS on cancer cells.
Protein Kinase C Alpha is a Central Node for Tumorigenic Transcriptional Networks in Human Prostate Cancer
Authors: Cooke Mariana , Zhang Xuyao , Zhang Suli , Eruslanov Evgeniy , Lal Priti , Daniel Reba E. , Feldman Michael D. , Abba Martin C. , Kazanietz Marcelo G.
Published: September 2022

Aberrant expression of protein kinase C (PKC) isozymes is a hallmark of cancer. The different members of the PKC family control cellular events associated with cancer development and progression. Whereas the classical/conventional PKCα isozyme has been linked to tumor suppression in most cancer types, here we demonstrate that this kinase is required for the mitogenic activity of aggressive human prostate cancer cells displaying aberrantly high PKCα expression. IHC analysis showed abnormal upregulation of PKCα in human primary prostate tumors. Interestingly, silencing PKCα expression from aggressive prostate cancer cells impairs cell-cycle progression, proliferation, and invasion, as well as their tumorigenic activity in a mouse xenograft model. Mechanistic analysis revealed that PKCα exerts a profound control of gene expression, particularly over genes and transcriptional networks associated with cell-cycle progression and E2F transcription factors. PKCα RNAi depletion from PC3 prostate cancer cells led to a reduction in the expression of proinflammatory cytokine and epithelial-to-mesenchymal transition (EMT) genes, as well as a prominent downregulation of the immune checkpoint ligand PD-L1. This PKCα-dependent gene expression profile was corroborated in silico using human prostate cancer databases. Our studies established PKCα as a multifunctional kinase that plays pleiotropic roles in prostate cancer, particularly by controlling genetic networks associated with tumor growth and progression. The identification of PKCα as a protumorigenic kinase in human prostate cancer provides strong rationale for the development of therapeutic approaches toward targeting PKCα or its effectors.

Significance:

PKCα was found to be aberrantly expressed in human prostate cancer. Silencing the expression of this kinase from aggressive prostate cancer cell lines reduces their proliferative, tumorigenic, and invasive properties. In addition, our findings implicate PKCα as a major node for transcriptional regulation of tumorigenic, inflammatory, and EMT networks in prostate cancer, highlighting its potential relevance as a therapeutic target.
Should the CKD EPI Equation Be Used for Estimation of the Glomerular Filtration Rate in Obese Subjects?
Authors: Domislovic Marija , Domislovic Viktor , Fucek Mirjana , Jelakovic Ana , Gellineo Lana , Dika Zivka , Jelakovic Bojan
Published: September 2022

Introduction: The pandemic of obesity is strongly related to increase of chronic kidney disease (CKD) prevalence. The currently recommended CKD epidemiology collaboration (CKD EPI) equation has several serious limitations, particularly in obese subjects who have high body surface area (BSA). The aim of our study was to analyze differences in the prevalence of CKD between CKD EPI and de-indexed equations where individual BSA was used. Methods: In a total of 2,058 subjects (random sample from a general rural population, 29.65% obese), BSA was estimated using DuBois and DuBois and Moesteller equations and included into the de-indexed equations (CKD DBi, CKD Mi). CKD was classified according to the KDIGO guidelines, and glomerular hyperfiltration (GHF) was defined as 95th percentile, according to the gender and age decade. Results: In obese subjects, prevalence of CKD was significantly higher with CKD EPI than with CKD DBi and CKD Mi equations (9.5%, 6.1%, 5.3%, respectively; p < 0.001), while prevalence of GHF was significantly lower (3.8%, 12.3%, 12.8%, respectively; p < 0.001). Opposite results were observed in subjects with a body mass index <25 kg/m2 for CKD (5%, 7.1%, 7.2%; p = 0.07) and GHF prevalence (6.1%, 1%, 0.6%; p < 0.001). Discussion/Conclusions: The prevalence of CKD is overestimated, and the prevalence of GHF is underestimated in obese subjects using the CKD EPI equation, i.e., the CKD EPI equation is unreliable in one-third of the population. De-indexed equations should be recommended instead of the CKD EPI equation in epidemiological studies until direct measurement of the glomerular filtration rate becomes more available.
THE RELATION BETWEEN FINANCIAL, ECONOMIC INDICATORS AND FOREIGN TRADE-RELATED LOANS: THE CASE OF TURKEY
Authors: DİLEK Şerif , KAYHAN Fatih , İSLAMOGLU Mehmet
Published: September 2022

The purpose of this paper is to examine the relation between inflation, exchange rate (USD/TL, EUR/TL) and TRLIBOR (interest rate), which are among the main economic/financial indicators, and export loans related to foreign trade financing with particular reference to the Covid-19 Pandemic. Data is retrieved from BRSA, BIST-Connect Data Platform. The study covers Turkey for the years between 2015-2021. OLS method is employed. Findings of this paper is as follows; with some lag, the increase in export credits caused a decrease in the EUR exchange rate, while interest rates increased in parallel with the growth in export credits in the same period.
FAIREST: A Framework for Assessing Research Repositories
Authors: d'Aquin Mathieu , Kirstein Fabian , Oliveira Daniela , Schimmler Sonja , Urbanek Sebastian
Published: September 2022

The open science movement has gained significant momentum within the last few years. This comes along with the need to store and share research artefacts, such as publications and research data. For this purpose, research repositories need to be established. A variety of solutions exist for implementing such repositories, covering diverse features, ranging from custom depositing workflows to social media-like functions.

In this article, we introduce the FAIREST principles, a framework inspired by the well-known FAIR principles, but designed to provide a set of metrics for assessing and selecting solutions for creating digital repositories for research artefacts. The goal is to support decision makers in choosing such a solution when planning for a repository, especially at an institutional level. The metrics included are therefore based on two pillars: (1) an analysis of established features and functionalities, drawn from existing dedicated, general purpose and commonly used solutions, and (2) a literature review on general requirements for digital repositories for research artefacts and related systems. We further describe an assessment of 11 widespread solutions, with the goal to provide an overview of the current landscape of research data repository solutions, identifying gaps and research challenges to be addressed.
Nietzsche and the Self-Overcoming of Historical Consciousness
Authors: Winfree Jason Kemp
Published: September 2022

This paper addresses the self-overcoming of historical consciousness in Nietzsche’s “The Uses and Disadvantages of History for Life” and contemporaneous texts. I argue that Nietzsche’s particular historical awareness, which conditions his treatment of historiography [Historie], is indebted to the lineage of German Idealism it also overtly contests. That contestation reaches its apex in Nietzsche’s valorization of appearance and the redirection of poietic power, which enables him to affirm an art of history rather than a science thereof, indeed, an art aligned with justice.
Toward a Phenomenology of “The Other World”: This World as It Is for No One in Particular
Authors: Hayes Shannon
Published: September 2022

In the working notes to The Visible and the Invisible, Merleau-Ponty uses punctum caecum (physiological blind spot) as a metaphor for the unconscious and the invisible of the visible. I read the punctum caecum alongside Merleau-Ponty’s call in another working note to “[e]laborate a phenomenology of the other world.” I take up a phenomenology of the other world as directed toward the punctum caecum of this world. I begin with a discussion of Merleau-Ponty’s unconscious and continue its unfinished thought by drawing in other iterations of the punctum caecum – the involuntary memories in Marcel Proust’s, In Search of Lost Time, the punctum Roland Barthes finds in Camera Lucida and in words that refer to other worlds. Among Merleau-Ponty, Proust, and Barthes I sense something shared – a latent intentionality, and a question about mourning expressed across their disparate texts: the other who existed once, do they exist still? The other who looked at me once, do they look at me still?
UNESCO’S Judges’ Initiative
Authors: Canela Guilherme , Burki Namara , Menon Samrita
Published: September 2022

Human rights, the rule of law and democracy are interlinked and mutually reinforcing. Within the framework of international human rights law, the right to freedom of expression particularly stands out, as it constitutes a pre-requisite for the fulfilment of other fundamental rights. In this regard, as ‘guardian of the rule of law’, the judiciary plays a particularly important role in guaranteeing the respect for the fundamental right to freedom of expression and its corollaries, access to information and the safety of journalists. To do so, however, judicial actors need to be well versed on freedom of expression challenges (both online and offline), and knowledgeable about the related international standards and regional jurisprudence. To share best practices and lessons learnt in this regard, this essay will be structured in two parts: first, it will discuss the crucial role of an independent judiciary in protecting the rights to freedom of expression and access to information, while falling under the obligation to act in full transparency itself. Second, it will present an in-depth analysis of the United Nations Educational, Scientific and Cultural Organization (UNESCO)’s Judges’ Initiative, presenting the concrete experience of a United Nations’ body engaging with its constituents. At the heart of this endeavor is the goal of enhancing the international human rights legal framework, by raising, in full cooperation with them, the knowledge an capacities of judicial actors from around the world on the need to protect and promote freedom of expression, access to information, and the safety of journalists to guarantee the respect for human rights, democracy, and the rule of law.
Anatomical and palynological comparison of three endemic species of Teucrium sect. Teucrium of Turkey
Authors: ATASAGUN BAYRAM
Published: September 2022

Teucrium ekimii, T. pestalozzae and T. semrae are three endemic species of Turkey belonging to Teucrium sect. Teucrium. These species grow in the western Mediterranean region of the country and are morphologically similar to each other. In the present study, the three species underwent anatomical examination of the stems, leaves and palynological studies for a better characterization of the species and in search of additional diagnostic characters. Quantitative characters were subjected to one-way analysis of variance (ANOVA) and boxplot. In general, these species are anatomically similar, though there are significant differences in stem cuticle thickness, stem epidermis length and width, leaf lower epidermis width and midrib parenchyma width. Pollen grains of all three species are prolate, medium-sized and tricolpate. The exine ornamentation is microverrucate-perforate in T. ekimii, verrucate in T. pestalozzae and microverrucate in T. semrae. Considering palynological characters, polar axis and t (apocolpium) were identified as taxonomically significant characters.
Taxonomy of Diamesa steinboecki group (Diptera: Chironomidae: Diamesinae), with description and DNA barcoding of known species. II. Subgroups davisi, leona and loeffleri
Authors: MAKARCHENKO EUGENYI A. , SEMENCHENKO ALEXANDER A. , PALATOV DMITRY M.
Published: September 2022

Illustrated redescription of the adult males Diamesa alpina Tokunaga from the Russian Far East and North America, D. amplexivirilia Hansen from Arctic and the Russian Far East, D. saetheri Willassen from Chukotka Region and Kolyma River basin, D. lupus Willassen from Alaska, D. serratosioi Willassen from Norway and Russian Far East, D. leoniella Hansen from Alaska, D. leona Roback from Eurasia, D. japonica Tokunaga from Japan and Russian Far East, D. khumbugelida Saether et Willassen and D. loeffleri Reiss from Himalayas are provided.

Morphological data and DNA sequences of the mitochondrial cytochrome c oxidase subunit I gene (COI) were used to delimit of seven species from subgroups davisi (D. alpina, D. amplexivirilia, D. serratosioi), leona (D. japonica, D. leona) and loeffleri (D. khumbugelida, D. loeffleri). Taxonomic remarks with data on geographical distribution of the investigated species are given.
Taxonomic study of the leafhopper genus Rufitidia (Hemiptera: Cicadellidae: Typhlocybinae: Erythroneurini) from China, with descriptions of two new species
Authors: ZOU HONGFEN , LIN SHUANGHU , HUANG MIN , ZHANG YALIN
Published: September 2022

The genus Rufitidia Dworakowska is reviewed with two new species from China: R. fissa sp. nov. and R. dissidens sp. nov. Detailed morphological descriptions and illustrations of these two new species and a key to all known species (males) are provided.
Description of a new species of the leafhopper genus Chinaocerus (Hemiptera: Cicadellidae) from Yunnan, China
Authors: LI MIN , WANG JIAJIA , WANG XIANYI , DAI RENHUAI
Published: September 2022

A new species Chinaocerus dentaedeagus sp. nov. is described and illustrated from Yunnan, China. The new species can be distinguished from other species of the genus Chinaocerus by aedeagal shaft subapex with pair of dentate lamellar. Meanwhile, a checklist of the genus and a key to the genera from China are provided.
Cochlear Implant Salvage in Case of Grounding Wire Extrusion
Authors: Behnke John , Williamson Adrian , Castaño Johnathan E.
Published: September 2022

Objectives:

Cochlear implantation (CI) is a safe and effective procedure for hearing rehabilitation, with few major complications. Device exposure or extrusion is a rare but major complication that often necessitates explantation due to wound dehiscence or infection. The objective of this report is to present a previously undescribed case in which the cochlear implant grounding wire extruded in 16-month-old patient 3 months post-operatively in the absence of trauma or infection.

Methods:

We reviewed the case report and the pertinent literature.

Results:

A 16-month old male suffered extrusion of his left cochlear implant grounding wire without known etiology 86 days post-operatively after bilateral cochlear implantation. The patient was taken for surgery, and the electrode was reimplanted without complication followed by 48 hours of prophylactic intravenous antibiotics. Nine month follow up revealed the implant functioning appropriately, with no further major complications encountered.

Conclusion:

We present this unique case to demonstrate that a cochlear implant grounding wire extrusion is not necessarily an indication for explantation in the absence of infection.
Can Community Policing Reduce the Chilling Effect of Immigration Enforcement on Latinx Crime Reporting? Evidence from Los Angeles
Authors: Muchow Ashley N.
Published: September 2022

While scholars have linked immigration enforcement with reductions in Latinx crime reporting, little research has examined the tools localities can use to counter reporting declines. This study assesses whether a community policing program adopted by the Los Angeles Police Department (LAPD) offset documented decreases in Latinx domestic violence reporting after President Trump assumed office. Using data on crimes reported to the LAPD between 2014 and 2019, this study finds that while domestic violence reports made by Latinx victims declined elsewhere after Trump took office, they increased in areas exposed to the community policing program. Results suggest that community policing may be a viable tool to encourage help-seeking behavior among residents vulnerable to deportation.
The Lived Experiences of Bereaved Filipino Families of the Deceased Due to the COVID-19 Pandemic
Authors: Gamad Mary Joyce G. , Managuio Patricia Danielle V. , Pastor Mark Anthony A. , Ariola Arianne Gail G. , Diane Mark Gerard A. , Silva Ricamarie P.
Published: September 2022

The typical highlight of Filipino mourning of conducting funerals and burials has ceased due to recent health guidelines which required the deceased, who tested positive for the virus, to be cremated and buried right away to avoid further spread of the disease – making bereavement more complicated. This paper investigates the experiences of bereaved Filipino families who lost their loved ones to COVID-19 through a qualitative research design. Researchers explored the experiences of at least three (3) COVID-19 bereaved families through a descriptive phenomenological approach and analyzed the data using thematic analysis to extract the bereavement process experienced by the participants. The findings of the study highlight the changes to the Filipino funeral practice caused by the pandemic and the major roles of connectedness, and cultural and religious beliefs in the Filipino bereavement experience.
The Impact of Offering Baccalaureate Degrees on Institutional Enrollment in Community Colleges
Authors: Wright-Kim Jeremy
Published: September 2022

Objective:

The community college sector plays a vital role in broadening access to education and helping states meet their workforce needs. An emerging trend and potential lever to better achieve these goals is the community college baccalaureate or CCB. Yet, opponents wonder whether CCBs may lead community colleges to abandon their traditional logics. This study attempts to help address this question.

Methods:

Using institution-level panel data, I employ various difference-in-difference approaches to estimate the impact of CCB adoption on overall enrollment levels, as well as the enrollment of historically underrepresented student populations.

Results:

I find that CCB adoption leads to significant increases in overall student enrollment; these results are robust to alternative specifications and control groups. Yet, enrollment-related impacts vary by selected student populations. I find no consistent evidence that CCB adoption shifts community colleges away from their commitment to underrepresented students, though there may be a tipping point not yet reached by current levels of CCB adoption.

Contributions:

These findings have important implications for policy and practice as institutional leaders and policy makers continue to debate, adopt, and implement baccalaureate programing at the community college level.
Gypsy Anarchism: Navigating Ethnic and Political Identities
Authors: Sierra María , Pro Juan
Published: September 2022

One of the many stereotypes included in the generally negative – occasionally Romantic – representations and discourses that have burdened the Romani people is the alleged existence of a natural link between the ‘Gypsy’ way of life and anarchism. This article studies the extent of an actual historical relationship between anarchism as a political worldview and the ‘Gypsy’-Roma ethnic status beyond reductionist stereotypes. It investigates, on the one hand, the agency of Romani subjects in the labour movement and anarchism by means of a case study of Spain in the interwar years, and, on the other, it examines the cases of a number of European emigrants who chose to closely link anarchism as a political option to a Romani identity in their struggle against capitalism and fascism. Both sets of case studies are used to reflect on the political nature of racial-ethnic identity constructions, to question the dilemmas of cultural appropriation and to propose a dense analysis that reveals the historicity of identities of this type.
‘Nous, les Artistes Tsiganes’. Intellectual Networks and Cultural Spaces for Ethnic Assertion in France (1949–1989)
Authors: Barrera Begoña
Published: September 2022

This article focuses on the cultural and artistic side of Tsigane associationism in France. Its purpose is to demonstrate that a new identity was created between the 1950s and the 1980s: the Tsigane artist and intellectual. This identity resisted both primitivist, naïve, folkloric stereotypes and the label ‘Rom’ coined by the Romani movement. For this to happen, several other transformations were necessary, which this article will also explore, such as the resignification of the exonym ‘Tsigane’ as a national and ethnic identity marker. These processes are explained with reference to two closely linked objects of study: the Association des Études Tsiganes (Association for Tsigane Studies), a circle of ‘experts’ on the Tsigane world, founded in 1949, and second, the Association Initiatives Tsiganes (Tsigane Initiatives Association), which was created from within the previous movement in 1983, but was led by Tsigane artists and intellectuals who put their own form of cultural activism into practice.
Tsyganshchina (цыганщина) and Romani Musicians in Tsarist, Soviet and Post-Soviet Russia: Change and Continuity
Authors: Piotrowska Anna G.
Published: September 2022

The main goal of this paper is to recognize and explain the specificity of the public presence of Romani musicians in Russia, predominantly in the long nineteenth century as well as in the new (Soviet and post-Soviet) political situation of the twentieth century. The article offers a historically oriented outline of the Romani musical traditions deeply embedded into the cultural, political and economic situation of the country. A special focus is placed on the phenomenon of the so-called ‘Gypsy choirs’ and their reception in Russia both by Russians and by foreigners, the latter being often surprised that while in Central and Western Europe Romani musicians were known for instrumental music, in Russia their vocal music (particularly so-called ‘Gypsy romances’) gained considerable popularity. The paper argues that Romani musicians from ‘Gypsy choirs’ identified and learnt to address the Russian aesthetics and thus managed to secure and sustain their unique position within the Russian culture.
Romani Berlin: ‘Gypsy’ Presence, the Culture of the Horse Market and the Shaping of Urban Space 1890–1933
Authors: Rosenhaft Eve
Published: September 2022

This article explores the Romani contribution to the construction of urban space(s), focusing on the city of Berlin between about 1890 and 1933, with a particular emphasis on the period between the turn of the century and the First World War. Drawing on press reports, it offers evidence for public awareness of a new Romani presence in and around the city, and proposes that media representations of ‘Gypsies’ in the new suburbs reflected the heightened sensitivity to setting boundaries between urban and rural, civilized and uncivilized, that informed Berlin's ‘urban imaginary’ at a time of expansion and modernization. In a second step, the agency of Romani Berliners in defining the city as a multi-ethnic metropolis and shaping spaces within it is considered. The account focuses on productive interactions between Romani and non-Romani actors in the horse markets which drew Sinti and Roma to settle in Berlin and on the lives of horse-dealing families in the city at large, including the tendential emergence of ‘Gypsy’ neighbourhoods.
Phonological cross-linguistic influence at the initial stages of L3 acquisition
Authors: Kopečková Romana , Gut Ulrike , Wrembel Magdalena , Balas Anna
Published: September 2022

This study investigates sources of phonological cross-linguistic influence (CLI) at the initial stages of third language (L3) acquisition in light of the predictions of the second language (L2) Status Factor Model, the Typological Primacy Model, the Cumulative Enhancement Model, the Linguistic Proximity Model and the Scalpel Model. The productions of L3 rhotic sounds, /w/ and final obstruent devoicing, elicited in a delayed repetition task, were analysed auditorily in two groups of adolescent instructed learners with L1-German–L2-English–L3-Polish and L1-Polish–L2-English–L3-German language backgrounds. The results showed that dominant articulatory routines from the L1 play an important role in determining the source(s) of phonological CLI in the initial stages of L3 acquisition, at least in a learning constellation when L2 articulations have not been mastered yet in a consistently target-like manner. Based on loglinear and multiple correspondence analyses, the sources of phonological CLI were found in this study to vary feature-by-feature, thus giving some support to the Linguistic Proximity Model and the Scalpel Model. However, the high inter- and intra-individual variation that was found is so far not accounted for by any of the existing models.
Current Practices for Genetic Testing in Neonatal Extracorporeal Membrane Oxygenation: Findings from a National survey
Authors: Wild K. Taylor , Miquel-Verges Franscesca , Rintoul Natalie E , DiGeronimo Robert , Keene Sarah , Hamrick Shannon E , Mahmood Burhan , Rao Rakesh , Carr Nicholas R ,   Children’s Hospitals Neonatal Consortium (CHNC)
Published: September 2022

Introduction: Comprehensive genetic testing with whole-exome (WES) or whole-genome (WGS) sequencing facilitates diagnosis, can optimize treatment, and may improve outcomes in critically ill neonates, including those requiring extracorporeal membrane oxygenation (ECMO) for respiratory failure. Our objective was to describe practice variation and barriers to the utilization of comprehensive genetic testing for neonates on ECMO.

Methods: We performed a cross-sectional survey of Level IV neonatal intensive care units in the United States across the Children’s Hospitals Neonatal Consortium (CHNC).

Results: Common indications for WES and WGS included concerning phenotype, severity of disease, unexpected postnatal clinical course, and inability to wean from ECMO support. Unexpected severity of disease on ECMO was the most common indication for rapid genetic testing. Cost of utilization was the primary barrier to testing. If rapid WES or WGS were readily available, 63% of centers would consider incorporating universal screening for neonates upon ECMO cannulation.

Conclusion: Despite variation in the use of WES and WGS, universal testing may offer earlier diagnosis and influence the treatment course among neonates on ECMO. Cost is the primary barrier to utilization and most centers would consider incorporating universal screening on ECMO if readily available.
Ecthyma gangrenosum and severe neutropenic sepsis caused by Staphylococcus aureus infection in a previously healthy child: a case report
Authors: Zhang Xinjuan , Yu Yanping
Published: September 2022

Ecthyma gangrenosum (EG) is a potentially lethal skin infection mainly caused by Pseudomonas aeruginosa, but other causative pathogens have also been reported. EG usually occurs locally and often arises in immunocompromised patients. The fatality rate can be extremely high if a systemic infection leading to sepsis occurs. EG and severe sepsis caused by Staphylococcus aureus infection are extremely rare in healthy children. However, upon occurrence, disease progression can be rapid, and the mortality rate is high. This current case report describes a previously healthy child with no underlying diseases who developed EG in the facial and perianal regions following S. aureus infection. The infection rapidly progressed to sepsis, septic shock, and persistent severe neutropenia. The patient also developed drug-resistant bacterial infections that spread rapidly and resulted in multiorgan failure. The patient was treated with antibiotics, but she died of organ failure despite extracorporeal membrane oxygenation support. EG caused by S. aureus has the potential to progress rapidly, leading to septic shock and severe neutropenia. Patients should be identified at an early stage and promptly treated with antibiotics. However, the improvement of neutropenia and prevention of secondary infections remain the focus of our research.
Oral midodrine does not expedite liberation from protracted vasopressor infusions: A case-control study
Authors: Wood Alexander JT , Rauniyar Rashmi , Jacques Angela , Palmer Robert N , Wibrow Bradley , Anstey Matthew H
Published: September 2022

Vasopressor dependence is a common problem affecting patients in the recovery phase of critical illness, often necessitating intensive care unit (ICU) admission and other interventions which carry associated risks. Midodrine is an orally administered vasopressor which is commonly used off-label to expedite weaning from vasopressor infusions and facilitate discharge from ICU. We performed a single-centre, case-control study to assess whether midodrine accelerated liberation from vasopressor infusions in patients who were vasopressor dependent. Cases were identified at the discretion of treating intensivists and received 20 mg oral midodrine every eight h from enrolment. Controls received placebo. Data on duration and dose of vasopressor infusion, haemodynamics and adverse events were collected. Between 2012 and 2019, 42 controls and 19 cases were recruited. Cases had received vasopressor infusions for a median of 94 h versus 29.3 h for controls, indicating prolonged vasopressor dependence amongst cases. Midodrine use in cases was not associated with faster weaning of intravenous (IV) vasopressors (26 h versus 24 h for controls, P = 0.51), ICU or hospital length of stay after adjustment for confounders. Midodrine did not affect mean heart rate but was associated with bradycardia. This case-control study demonstrates that midodrine has limited efficacy in expediting weaning from vasopressor infusions in patients who have already received relatively prolonged courses of these infusions.