bluuebunny/crossref_metadata_2025 huggingface dataset:
Pemanfaatan Minyak Serai (Cymbopogon nardus L.) dan Jarak Kepyar (Ricinus communis L.) Untuk Pengendalian Ulat Krop Kubis (Crocidolomia pavonana F.)
Authors: Susanto Ainun Nandini Putri , Dono Danar , Nasahi Ceppy
Published: February 2024

Crocidolomia pavonana adalah salah satu hama utama pada tanaman kubis. Pestisida nabati merupakan salah satu alternatif pengendalian yang dapat dilakukan petani. Salah satunya adalah minyak serai wangi dan minyak jarak. Pada penelitian ini diuji bagaimana pengaruh insektisida nabati dari minyak serai wangi dan minyak jarak dalam bentuk tunggal dan campuran dalam mengendalian hama C. pavonana. Metode uji menggunakan metode residu pada pakan dengan metode celup daun pada konsentrasi 0,1% dan 0,5%. Hasil penelitian menunjukkan bahwa pada campuran serai wangi dan jarak (rasio 3:1) memberikan kematian C. pavonana tertinggi 86,67% (konsentrasi 0,1%) dan 100% (konsentrasi 0,5%). Pemberian minyak juga memberikan pengaruh terhadap penekanan konsumsi pakan dan pengurangan bobot pupa. Hasil penelitian dapat dijadikan rekomendasi kepada petani untuk memanfaatkan minyak Serai Wangi dan minyak Jarak Kepyar untuk pengendalian hama C. pavonana pada tanaman kubis sebagai alternatif pengendalian hama yang ramah lingkungan.
Implementation of Family Planning Village Program on the Effectiveness of Acceptor Users in Manjapai Village, Gowa Regency
Authors: Nurinzana Nurinzana , Raodhah Sitti , Rusmin Muhammad
Published: February 2024

Background.  The village family planning program is one of the government's innovative programs to reduce fertility rates in order to achieve balanced population growth, increase family resilience and welfare, prepare and regulate marriage and pregnancy, control birth rates and reduce maternal and child mortality after childbirth. The purpose of this study was to determine the implementation of the village family planning program in Kaluarrang Hamlet, Manjapai Village, Bontonompo District, Gowa Regency. Methods.   This type of research is qualitative with a case study approach. Collecting data using interview and documentation techniques with a total sample of 13 respondents. The data collected from this study were sourced from primary data and secondary data. Results.   The research results obtained are: (1) Communication in the implementation of the Kampung KB program so far can be said to have been implemented but has not been running effectively (2) The available resources are sufficient for both human, financial and budgetary resources originating from the APBN (3 ) Disposition related to the attitude of the implementer is not optimal due to lack of awareness and commitment in implementing this KB village program (4) The bureaucratic structure from the results of this study shows that the formation of the KB Village management has been carried out based on the SOP at the time of the declaration of formation in the KB Village. Conclusion.  This study found that it is necessary to improve communication from the dimensions of consistency, clarity of information and transparency between implementors and target groups as well as monitoring in the implementation of Kampung KB program policies.
Proprioseiopsis zaheri n. sp. (Acari: Phytoseiidae) from Egypt with a key to the Proprioseiopsis species reported from the country
Authors: Sanad Ahmad Said , Abo-Shnaf Reham
Published: February 2024

Proprioseiopsis zaheri n. sp. is described based on adult females collected from giant reed plant, Arundo donax, at Monufia governorate, Egypt. A key to the Proprioseiopsis species found in Egypt is also provided.
First record of the mite family Teneriffiidae (Prostigmata: Anystoidea) from Saudi Arabia with the description of a new species
Authors: Mirza Jawwad Hassan , Kamran Muhammad , Alatawi Fahad Jaber
Published: February 2024

The family Teneriffiidae Thor is reported for the first time from Saudi Arabia, with the description of a new species of the genus Parateneriffia Thor, P. abhaensis n. sp. The specimens of new species were found in soil litter and leaf debris collected from Southwestern Region (Abha) of Saudi Arabia.
Detection performance and prognostic value of initial bone marrow involvement in diffuse large B-cell lymphoma: a single centre 18F-FDG PET/CT and bone marrow biopsy evaluation study
Authors: Doma Andrej , Zevnik Katarina , Studen Andrej , Prevodnik Veronika Kloboves , Gasljevic Gorana , Novakovic Barbara Jezersek
Published: February 2024

Background

Detection of bone marrow involvement (BMI) in diffuse large B-cell lymphoma (DLBCL) typically relies on invasive bone marrow biopsy (BMB) that faces procedure limitations, while 18F-FDG PET/CT imaging offers a noninvasive alternative. The present study assesses the performance of 18F-FDG PET/CT in DLBCL BMI detection, its agreement with BMB, and the impact of BMI on survival outcomes.

Patients and methods

This retrospective study analyzes baseline 18F-FDG PET/CT and BMB findings in145 stage II–IV DLBCL patients, evaluating both performance of the two diagnostic procedures and the impact of BMI on survival.

Results

DLBCL BMI was detected in 38 patients (26.2%) using PET/CT and in 18 patients (12.4%) using BMB. Concordant results were seen in 79.3% of patients, with 20.7% showing discordant results. Combining PET/CT and BMB data, we identified 29.7% of patients with BMI. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of PET/CT for detecting DLBCL BMI were 88.4%, 100%, 100%, 95.3%, and 96.5%, respectively, while BMB showed lower sensitivity (41.9%) and NPV (46.8%). The median overall survival (OS) was not reached in any gender subgroup, with 5-year OS rates of 82% (total), 84% (female), and 80% (male) (p = 0.461), while different International Prognostic Index (IPI) groups exhibited varied 5-year OS rates: 94% for low risk (LR), 91% for low-intermediate risk (LIR), 84% for high-intermediate risk (HIR), and 65% for high risk (HR) (p = 0.0027). Bone marrow involvement did not impact OS significantly (p = 0.979).

Conclusions

18F-FDG PET/CT demonstrated superior diagnostic accuracy compared to BMB. While other studies reported poorer overall and BMI 5-year OS in DLBCL, our findings demonstrated favourable survival data.
RAD54B promotes gastric cancer cell migration and angiogenesis via the Wnt/β-catenin pathway
Authors: Li Jianchao , Geng Hui , Li Xin , Zou Shenshan , Xu Xintao
Published: February 2024

Background

Gastric cancer is an epidemic malignancy that is commonly diagnosed at the late stage. Evidence has elucidated that RAD54B exerts a crucial role in the progress of various tumors, but its specific role and mechanism in gastric cancer remain gloomy.

Materials and methods

The level of RAD54B was detected by western blot. RAD54B expression was downregulated or upregulated in both MKN45 and AGS cells by the transfection of shRAD54B or overexpression plasmid, respectively. The role of RAD54B in the growth, migration, invasion and tube formation of gastric cancer was evaluated by Edu, colony formation, transwell and tube formation assays. In addition, the molecular mechanism of RAD54B in gastric cancer was also determined by western blot. Moreover, in vivo experiment was conducted in xenografted mice.

Results

The expression of RAD54B was discovered to be upregulated in gastric cancer based on the ATGC and GEPIA databases, which was also confirmed in gastric cancer cell lines. Moreover, overexpression of RAD54B enhanced the growth, migration, invasion, tube formation and Wnt/β-catenin signaling axis in AGS and MKN45 cells. As expected, knockdown of RAD54B in AGS and MKN45 cells reversed these promotions. More importantly, in vivo assay also verified that RAD54B accelerated the growth of gastric cancer and Wnt/β-catenin signaling pathway.

Conclusions

Both loss-of-function and gain-of-function assays demonstrated that RAD54B facilitated gastric cancer cell progress and angiogenesis through the Wnt/β-catenin axis.
Role of diffusion-weighted imaging in response prediction and evaluation after high dose rate brachytherapy in patients with colorectal liver metastases
Authors: Karim Salma , Seidensticker Ricarda , Seidensticker Max , Ricke Jens , Schinner Regina , Treitl Karla , Rübenthaler Johannes , Ingenerf Maria , Schmid-Tannwald Christine
Published: February 2024

Background

The aim of the study was to assess the role of diffusion-weighted imaging (DWI) to evaluate treatment response in patients with liver metastases of colorectal cancer.

Patients and methods

In this retrospective, observational cohort study, we included 19 patients with 18 responding metastases (R-Mets; follow-up at least one year) and 11 non-responding metastases (NR-Mets; local tumor recurrence within one year) who were treated with high-dose-rate brachytherapy (HDR-BT) and underwent pre- and post-interventional MRI. DWI (qualitatively, mean apparent diffusion coefficient [ADCmean], ADCmin, intraindividual change of ADCmean and ADCmin) were evaluated and compared between pre-interventional MRI, first follow-up after 3 months and second follow-up at the time of the local tumor recurrence (in NR-Mets, mean: 284 ± 122 d) or after 12 months (in R-Mets, mean: 387+/−64 d). Sensitivity, specificity, positive predictive values (PPVs), and negative predictive values (NPVs) for detection of local tumor recurrence were calculated on second follow up, evaluating (1) DWI images only, and (2) DWI with Gd-enhanced T1-weighted images on hepatobiliary phase (contrast-enhanced [CE] T1-weight [T1w] hepatobiliary phase [hb])

Results

ADCmean significantly increased 3 months after HDR-BT in both groups (R-Mets: 1.48 ± 0.44 and NR-Mets: 1.49 ± 0.19 x 10−3 mm2;/s, p < 0.0001 and p = 0.01), however, intraindividual change of ADCmean (175% vs.127%, p = 0.03) and ADCmin values (0.44 ± 0.24 to 0.82 ± 0.58 x 10−3 mm2/s) significantly increased only in R-Mets (p < 0.0001 and p < 0.001). ADCmin was significant higher in R-Mets compared to NR-Mets on first follow-up (p = 0.04). Sensitivity (1 vs. 0.72), specificity (0.94 vs. 0.72), PPV (0.91 vs. 0.61) and NPV (1 vs. 0.81) could be improved by combining DWI with CE T1w hb compared to DWI only.

Conclusions

DW-MRI seems to be helpful in the qualitative and quantitative evaluation of treatment response after HDR-BT of colorectal metastases in the liver.
Low Interest Rates and Uncreative Destruction in the Office Market
Authors: Olszewski Krzysztof , Trojanowski Dariusz , Łaszek Jacek
Published: February 2024

Low interest rates were introduced in the global economy to support the weak economic growth that followed the global financial crisis. In the real estate sector, low interest rates usually lead to a boom in investment and prices. This boom, however, is not spread throughout the economy, but rather concentrated in major cities. We demonstrate this phenomenon on the example of the office market in Warsaw (Poland). While it would be beneficial for the Polish economy to develop office space in smaller cities that have an insufficient supply of modern office space, investors have focused mainly on the capital. This has not only led to an increase in the cost of building land and construction, but has also pushed some relatively new existing office buildings off the market. We call such behaviour uncreative destruction and explain why it was possible.
Hydroxychloroquine Induced Cardiotoxicity: A Case Series
Authors: Schneider Artur , Sadhana Jonna , Menindez Maximiliano Diaz , Jeevaratnam Suren , Balistreri Lisa , Thomas Colleen , Chirila Razvan , Berianu Florentina
Published: February 2024

Hydroxychloroquine (HCQ) induced cardiotoxicity is a rare diagnosis and is often associated with chronic use of the medication. It has been shown that chronic HCQ use is associated with a drug-induced cardiomyopathy mainly driven by acquired lysosomal storage defects leading to hypertrophy and conduction abnormalities. As the only proven treatment is the discontinuation of the offending agent, prompt recognition is required to avoid further exposure to the drug and potential progression of disease. History, physical examination and advanced imaging modalities are useful diagnostic tools, but more invasive testing with an endomyocardial biopsy is required for definitive diagnosis. We present a descriptive case series of ten patients that were diagnosed with biopsy proven HCQ cardiotoxicity.
The importance of the enzyme Gamma-glutamyltransferase in the pathogenic cluster in type2 diabetic patient
Authors: Virgolici Bogdana , Dobre Maria Zinaida , Lixandru Daniela , Petcu Laura , Picu Ariana , Ionescu-Târgovişte Constantin , Greabu Maria , Bacanu Elena Violeta
Published: February 2024

Introduction. Gamma-glutamyltransferase (GGT) is a liver enzyme involved in inflammation and oxidative stress. It is already known that MCP-1 (Monocyte Chemoattractant Protein-1) and TNF-α (tumour necrosis factor) as inflammatory markers, ICAM-1 (Intercellular Adhesion Molecule-1) as an endothelial dysfunctional marker, and glutathione, as an antioxidant, have abnormal levels in type 2 diabetic patients. The aim of this study was to evaluate the specific biological picture of type 2 diabetic patients that also associate higher GGT activity.

Methods. Eighty-five type 2 diabetes, aged 40–70 years with a duration of diabetes less than 6 years without infections, epilepsy, chronic liver or cardiac diseases, without alcohol consumption (>20 g/day) were divided in two subgroups, those with normal and those with high abnormal GGT.

Results. The diabetic patients with high GGT (n=31) had dysglycaemia, dyslipidemia, higher inflammatory markers (CRP, TNF-α, MCP-1) and endothelial dysfunction (high leptin and sICAM). sICAM, serum MCP-1 and TNF-α levels had significant correlations with GGT activity (r= 0.38, r=0.30 and 0.26 respectively, p<0.05).

Conclusion. This study underlines that in non-alcoholic diabetic patients, with a duration of the metabolic disease less than 6 years, sICAM, serum MCP-1 and TNF-α might play an important role in dysmetabolism, and higher level for GGT represents the „red flag” for this condition.
An Explication of Anthropogenic Climate Change in Anuradha Roy’s An Atlas of Impossible Longing
Authors: Augustus Karen , Gnanadurai Christopher
Published: February 2024

Objective: Climate change is an alarming concept prevailing as a threat to human existence. The paper aims to emphasise on climate change, a concern for environment portrayed in Anuradha Roy’s novel An Atlas of Impossible Longing (2008). Extending this hypothesis, the paper aims to scrutinize the changes happening in the climate and environment in the novel during the partition period in India.
 
Method: The researchers have used qualitative research and to bring this research with a descriptive approach. However, the researcher lays out the study under the main theory of ecocriticism and narrows it down to the specific concept of ‘Climate change’.
 
Result: The novel An Atlas of Impossible Longing (2008) is set on the outskirts of West Bengal, which is located in the northern part of India. A widower character in the novel is finding it difficult to get attached to his motherless daughter who is quite close to an orphan boy named Mukunda, adopted by the family. The characters in the novel live in tune with nature and find certain difficulties to continue their lifestyle because of climate change.
 
Conclusion: In the explication on the concept of ‘climate change’ the researcher examines the relevant concepts like anthropocentric and anthropogenic which might be the cause of climate change. The main scope of this paper is to prioritize the concept of climate change for sustaining nature.
Single Mothers’ Perspectives on Social Welfare Programs for Women in Tamil Nadu
Authors: Dharani Muthu Kamarajan , Balamurugan Janarthanan
Published: February 2024

Objective: The study aims to examine the awareness of assistance policies and schemes for women among single mothers.  Therefore, the current study concentrates on demographic profile of single mothers and to examine the awareness, accessibility, and effectiveness of schemes and welfare policies among rural single mothers.
 
Methods: The research employed a quantitative and descriptive research design to examine 230 rural single mothers from the Gudiyattam Division, Vellore District. The responses are gathered using semi-structured questionnaires and interview schedules, and the data are analysed using the Statistical Package for the Social Sciences (SPSS).
 
Result and Conclusion: The study rejects the hypothesis because education plays a significant role in shaping an individual's pursuit of knowledge about the various welfare schemes instituted specifically for rural women. As a result, women must be educated at the grassroots level about these welfare schemes and policies for better survival in society, and policymakers must implement steps to raise the level of education for women in the nation.
 
Implications of the research: Awareness of the scheme is a crucial metric for determining the success of any programme. Even the utilisation rate of the programme is extremely low. Therefore, researching large samples of single mothers is necessary to identify their level of awareness and to benefit from the schemes.
GIS based Groundwater Vulnerability Assessment of Lahore a Metropolitan using Modified DRASTIC Model
Authors: Dear Dr. Syed Umair Shahid  , Javed Iqbal  , Maryam Khalil
Published: February 2024

The metropolitans of the developing countries are experiencing the hazard of low quality drinking water. Lahore, the heart of Pakistan, has over 12 million population and is going to face the shortage of clean drinking water. The study was designed to create a groundwater vulnerability map of Lahore using modified DRASTIC model. The water table, land use/cover, hydraulic conductivity, vadose zone, soil and aquifer media layers of Lahore aquifer were analyzed using ‘geostatistical analyst’ and ‘spatial analyst’ extensions of ArcGIS software to compute the groundwater vulnerability. The Vulnerability index of modified DRASTIC model ranged from 64 – 144. The spatial variability of modified DRASTIC index were divided into 4 categories, namely, Low, Moderate, High and Very High groundwater vulnerable zones. The modified DRASTIC model revealed that 51.38% areas have low vulnerability, 36.77% areas have moderate vulnerability, 9.48% areas have high vulnerability and 2.37% areas have very high vulnerability to groundwater pollution. The ‘high’ and ‘very high’ vulnerability classes were found in the western parts of Lahore. The results of modified DRASTIC model were validated using the groundwater contamination data of arsenic in the study area. The groundwater arsenic concentrations map also showed higher values in the northwestern parts while in the eastern parts of the study area, the arsenic concentrations had a decreasing trend. In Ravi Town, the arsenic concentrations were positively correlated with modified DRASTIC vulnerability index and inversely correlated with water table depth (p < 0.01). It is recommended that the arsenic removal plants should be installed at all the tubewells with higher arsenic levels (arsenic concentration > 50 ppb) to provide safe drinking water to the citizens of Lahore. It is recommended that the modified DRASTIC model based on geospatial techniques can be applied on other metropolitans of the world for taking preventive measures against massive water pollution.
Clinical intervention of pharmaceutical care as an indicator of quality of hospital care in pediatrics
Authors: Diniz Joaquim Alves , Nascimento Maria de Jesus , Azevedo Maria de Fátima , Borges Karla
Published: February 2024

Objective: To determine the frequency and nature of drug-related problems in hospitalized patients of a public pediatric hospital in Fortaleza/Ce. Metodology: Cross-sectional and retrospective study from the records of pharmaceutical interventions available in the database of the clinical pharmacy service. Results: Fifty-eight patients were included in the study. A total of 75 drug-related problems were identified with a frequency of 76.2% related to safety and these involved antimicrobial drugs (45.8%). Dose adequacy (35.7%) was the most frequent pharmaceutical intervention. The acceptability profile of the interventions was 64.4% for physicians and 100% by nurses. Final considerations: By analyzing the drug-related problems and pharmaceutical interventions, it was possible to know which aspects of the pediatric patients therapy were explored in the clinical pharmacist follow-up. We emphasize the importance of documentation of clinical practice for the construction of indicators and evaluation of the quality of pharmaceutical care in pediatrics.
Venous thromboembolism in childhood: a glance of 20 years in a paediatric intensive care unit
Authors: Almendra Margarida , Gonçalves Catarina , Casimito Anaxore , Estrada João
Published: February 2024

OBJETIVO: Caracterização clínica e abordagem de doentes com tromboembolismo (TEV). METODOLOGIA: Estudo retrospectivo, descritivo de doentes com idade <18 anos com TEV numa unidade de cuidados intensivos pediátricos num hospital terciário, durante 20 anos [2002-2021]. RESULTADOS: Identificados 51 doentes: trombose venosa profunda (TVP) (n=30), trombose venosa cerebral (TVC) (n=21), tromboembolismo pulmonar (TEP) (n=4), trombose da veia porta (TVPO) (n=2) e trombose da veia renal (TVR) (n=1). Em 5 doentes, coexistiram TVC e TVP (n=1); TEP e TVP (n=3); e TVR e TVP (n=1). Média de 2,6 casos/ano. 52,3% sexo masculino, mediana 6 anos [1M;17A]. A presença de cateter venoso central foi o principal fator de risco (72%) na TVP associado a edema na região; ecografia com doppler foi o exame escolhido. Todos com TEP foram adolescentes; 75% apresentaram queixas torácicas confirmadaos por angio-TC; identificados = 2 fatores de risco em cada doente. O caso de TVR foi numa criança de 2 anos com neoplasia renal. Os casos de TVPO foram adolescentes com sintomas de hipertensão portal. O principal sintoma na TVC foi cefaleia (63,6); 52,4% secundários àa infeção respiratória alta; estudo da trombofilia positivo em 42,9%. Analiticamente, todos apresentaram D-Dímeros elevados. A maioria iniciou anticoagulação com enoxaparina (86,3%), que mantiveram 3 a 6 meses pós-alta. Média de internamento 17,6 dias. Registrou-se 1 episódio de recorrência e 1 óbito não relacionado com TEV. DISCUSSÃO: A apresentação de fenóômenos tromboembólicos é inespecífica e as guidelines de abordagem são escassas na Pediatria. No entanto, é fulcral a sua deteção precoce, de modo a prevenir complicações.
Disain CAD Mekanisme Paralel Tiga Derajat Translasi Murni Dengan Rantai Kinematik Kombinasi Sambungan Revolut dan Prismatik
Authors: Huda Syamsul , Bur Mulyadi , Aris Zul Arifin
Published: February 2024

In this study it was discussed  kinematic design of a 3-RRRPP translational parallel mechanism. The design was carried out by using simulation performed using CAD software. Motion platform was analyzed based on screw and reciprocal screw theory. The evaluation mechanism performance was determined by introducing the stages of research in the form to determine mechanism parts such as base, links, and platform. The work was continued with the assembly process of each part. Furthermore, kinematic response represented by displacement of platform positions was figured out by a CAD simulation. Based on the results of the simulation, it was successfully designed the mechanism performing the translational motion of the Platform.
THE ROLE OF FIRM SIZE, PRICE EARNING RATIO AND PROFITABILITY TO IDIOSYNCRATIC VOLATILITY: EVIDENCE FROM BANKING INDUSTRY IN INDONESIA
Authors: Wijayani Dahyang Ika Leni , Walidina Aulia Rizki , Ismawanto Totok , Kusuma Wardani Devy Ayu
Published: February 2024

This study analyzes the effect of company size, price earnings ratio, and profitability on idiosyncratic volatility in state-owned banks listed on the Indonesia Stock Exchange in the period from 2011 to 2020, We use multiple regression analysis to tested the hypothesis. Firm size was measured by the natural logarithm of total assets, price earnings ratio by the comparison between market price and earnings per share, and profitability by return on equity. Idiosyncratic volatility is the fluctuation of stock price results form company specific information, measured by market regression model. Results show that size of the company, price earnings ratio and profitability have a negative and significant effect on idiosyncratic volatility. The increase of company size, price earnings ratio and profitability, consequently will lower the idiosyncratic volatility. From theoretical perspective, the finding of this research complied with three theories: valuation theory, prospect theory and life cycle theory whereas from managerial perspective, the business can effectively manage its assets and equity while carrying out its activities, resulting in strong fundamentals that may lower the amount of idiosyncratic risk.
ASIMETRI INFORMASI DALAM MEMODERASI PENGARUH KESESUAIAN KOMPENSASI, MORALITAS MANAJEMEN, DAN ETIKA KEPEMIMPINAN TERHADAP KECENDERUNGAN KECURANGAN AKUNTANSI
Authors: Pratiwi Risti , Mulyani Susi Dwi
Published: February 2024

This study aims to analyze the effect of suitability of compensation, management morality, leadership ethics, on the tendency of accounting fraud with information asymmetry as a moderating variable. The population in this study are employees of companies located in the Greater Jakarta area. The technique used in sampling is to use purposive sampling with the criteria of employees working in the accounting field, having worked for more than one year and participating in preparing the company's financial statements. Data collection in this study was carried out using a questionnaire. This study uses the SPSS program assisted by MS Excel as an analytical tool. The research results show that the appropriateness of compensation does not affect the tendency of accounting fraud, management morality has a negative effect on the tendency of accounting fraud, ethical leadership has no effect on the tendency of accounting fraud, information asymmetry does not weaken the effect of appropriateness of compensation on the tendency of accounting fraud, information asymmetry can weaken the effect of management morality on accounting fraud tendencies, and information asymmetry cannot weaken the influence of ethical leadership on accounting fraud tendencies.
E-LIXO ELETRÔNICO DE INFORMÁTICA EDUCAR PARA O DESCARTE CORRETO
Authors: Hayashi Arthur Yukio , De Ré Angelita Maria , Michelon Gisane Aparecida , Prestes Marcus Vinicyus Pires
Published: February 2024

O consumo desenfreado de equipamentos eletrônicos incentivado pela obsolescência programada desses produtos gera um acúmulo de lixo eletrônico crescente no mundo todo. Os computadores constituem a base do avanço da tecnologia e, por serem itens que são substituídos muito facilmente, exigem um cuidado maior. Pois, muitas vezes, computadores inteiros são descartados por conta de uma única peça defeituosa que impossibilita o seu funcionamento. Nesse contexto, o programa E-Lixo de Informática surge como uma alternativa extensionista, que junto à comunidade da UNICENTRO, realiza um processo que envolve desde a coleta até a doação de computadores e/ou peças após o conserto dos mesmos. Além de estabelecer uma relação com o ensino, pois a participação dos acadêmicos do curso de Ciência da Computação permite a esses complementarem de forma prática a formação acadêmica. Nos anos de 2022 e 2023 o programa realizou a doação para a comunidade universitária da UNICENTRO de desktops, notebooks, periféricos e componentes. Além disso foram doados também para projetos sociais e ações comunitárias.
Exhaust Gas and Plume Modeling Effects for Space Launch System Abort Scenarios
Authors: Boustani Jonathan , Applebaum Michael P. , Eppard William M. , Steva Thomas B. , Hall Les
Published: February 2024

Viscous computational fluid dynamics simulations depicting Space Launch System post Mode-1 abort scenarios are conducted and analyzed. The purpose of these simulations is to study the effect of attitude control motor and abort motor plume modeling on the drag of the aborted core stage. The simulations are first conducted with a multispecies and chemically reacting thermodynamic model. Following this, equivalent species are created for the exhaust gases. These equivalent species aim to provide results for core stage drag similar to the chemically reacting model at a lower computational cost. Finally, the exhaust gases are modeled as calorically perfect air. Under most scenarios, both simplified models predict the drag on the core stage close to that predicted by the chemically reacting simulations. In these cases, the flow conditions do not induce significant changes in the composition of the exhaust gas via afterburning. For simulations in which this is not the case, the properties of the simplified models deviate from the true mixture, yielding unsatisfactory results. Finally, the chemically reacting model is weighed against the associated increase in computational costs. The simplified models are at least four times less computationally expensive than the reacting model.
Research and Development Funding Patterns in BRICS Countries: Policy Lessons for South Africa’s Provincial Administration
Authors: Mokgokong Madikana Jackinah , Mukonza Ricky Munyaradzi
Published: February 2024

Over the years, research and Development (R&D) has been viewed as an enabler for economic growth and socio-economic development. Thus, the emergence of the knowledge economy across the globe has necessitated the need for countries to introspect on their readiness and preparedness to use research and development as a strategic tool for growth and socio-economic development. Scholars posit that R&D is a cornerstone for development around the globe because it has been widely documented that economic growth has been evident in countries that have invested in R&D. Thus, R&D is an integral part of socio-economic development. This is why the spine of this paper’s argument rests on the significance of research and development funding. This paper draws attention to the research and development funding in the BRICS countries.
UNJUK KERJA LIGHTNING ARRESTER TIPE LAP 24 CLASS 2 Uc 19.2 kV- Ur 24 kV MENGGUNAKAN METODE GENERATOR MARX
Authors: Pally Nazila A. , Amali Lanto Mohamad Kamil
Published: February 2024

Nazila A. Pally. 2023. Unjuk Kerja Lightning Arrester Tipe Lap 24 Class 2 Uc 19.2 kV – Ur 24 kV Menggunakan Metode Generator Marx. Skripsi, Program Studi S1 Teknik Elektro Jurusan Teknik Elektro, Fakultas Teknik, Universitas Negeri Gorontalo. Pembimbing I: Dr. Lanto Mohamad Kamil Amali, ST., MT dan Pembimbing II: Dr. Ir. Sardi Salim, M.Pd. Penelitian ini didasari oleh kinerja dari lightning arrester Tipe Lap 24 berbahan polimer dimana peneliti akan melihat karakteristik besarnya kapasitas pemotongan tegangan lebih dari lightning arrester tersebut dimana semakin besar kapasitas pemotongan lightning arrester, semakin baik pula fungsi proteksi yang dilakukannnya. Adapun metode yang digunakan dalam pengujian ini menggunakan metode Generator Marx. Tujuan penelitian ini menggunakan tegangan lebih akibat sambaran petir dimulai dari tegangan tertinggi 50 kV dengan step penurunan 5 kV sampai pada tegangan minimum 20 kV, sehingga lightning arrester yang di uji sudah memberikan pelindungan yang baik dalam bekerja memotong tegangan. Hasil penelitian ini membuktikan bahwa Karakteristik berdasarkan analisi yang dilihat secara umum lightning arrester dapat memotong tegangan. Adapun besarnya pemotongan tegangan berada pada range 6,627% – 18,255%. Untuk besarnya pemotongan tegangan terjadi pada simulasi induksi sambaran petir 40 kV yakni 18,255 % sedangkan pemotongan tegangan yang terkecil tejadi pada simulasi induksi sambaran petir 45 kV sebesar 2,267%.
Analisis Keandalan PLTU Lontar Berdasarkan Perhitungan Load of Load Probability (LoLP)
Authors: Jatnika Rangga
Published: February 2024

Pembangkit Listrik Tenaga Uap (PLTU) Lontar merupakan salah satu unit pembangkitan yang berperan utama dalam memenuhi kebutuhan listrik di Ibukota Jakarta dan sebagian wilayah Banten, sehingga keandalannya sangat diperhatikan. Perhitungan keandalan suatu pembangkitan dapat dianalisis dari seberapa sering suatu unit mengalami gangguan/seberapa sering tidak beroperasi. Data hasil gangguan suatu sistem dapat dihitung menggunakan rumus LoLP (Loss of Load Probability). LoLP menggambarkan besar-kecilnya peluang terhadap terjadinya kehilangan beban sebagai akibat kurangnya daya yang tersedia dalam sistem. Semakin kecil nilai LoLP berarti suatu sistem semakin sedikit peluang mengalami gangguan alias lebih andal. Berdasarkan Aturan Jaringan PLN, standar nilai LoLP adalah satu hari per tahun. Pada penelitian ini LoLP dihitung dengan cara manual berdasarkan data beban harian, kurva lama beban, dan nilai EFOR (Equivalent Forced Outage Rate). Dari hasil perhitungan LoLP, diperoleh besarnya LoLP PLTU Lontar di tahun 2022 nilainya 76,5 hari/tahun. Dengan demikian, maka keandalan PLTU Lontar di tahun 2022 masih di bawah standar PLN dan perlu ditingkatkan.
Analisis green price dan green place terhadap keputusan pembelian produk Tupperware di Kecamatan Tapian Dolok
Authors: Salqaura Siti Alhamra , Salqaura Siti Sabrina , Nasution Lily Nur Indah Sari
Published: February 2024

Aktivitas bisnis yang ramah lingkungan kerap dilaksanakan saat ini untuk mengurangi terjadinya pemanasan global. Tidak hanya aktivitas produksi yang ramah lingkungan namun juga aktivitas pemasaran yang ramah lingkungan (green marketing). Tujuan penelitian ini menganalisis komponen pemasaran hijau diantaranya green place dan green price dalam pengambilan keputusan pembelian produk Tupperware di Kecamatan Tapian Dolok. Penerapan green place dan green price penting untuk diinvestigasi seberapa jauh pengaruhnya terhadap keputusan pembelian konsumen. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif. Adapun populasi dalam penelitian ini adalah semua masyarakat di Kecamatan Tapian Dolok, dengan sampel 100 konsumen Produk Tupperware. Teknik penarikan sampel menggunakan teknik purposive sampling dengan memanfaatkan kuesioner. Metode analisis yang digunakan adalah analisis regresi linear berganda. Hasil penelitian membuktikan bahwa green price dan green place secara parsial (uji-t) maupun simultan (uji-F) tidak berpengaruh terhadap keputusan pembelian Produk Tupperware di Kecamatan Tapian Dolok.
ASISTENSI PENGGUNAAN E-FILING DALAM PELAPORAN SPT TAHUNAN BAGI WAJIB PAJAK ORANG PRIBADI DI KPP PRATAMA KARAWANG
Authors: Nurhidayat Intan , Mahpudin Endang
Published: February 2024

Abstract. Some taxpayers do not understand how to operate e-filing because the various features and menus seem complicated. Therefore, assistance in filling out and reporting the Annual SPT is needed to assist individual taxpayers in operating e-filing to submit the Annual SPT. The method applied in this service is assistance in filling out and reporting the annual SPT to WPOP located in the Karawang area with 3 (three) implementation stages, namely the technical guidance stage, the assistance implementation stage, and the evaluation stage. Around 4,102 taxpayers received assistance from the tax volunteer team to submit SPT 1770SS and SPT 1770S. This assistance was carried out offline for 2 (two) months, namely February and March 2023. To measure the success of implementing this assistance, KPP Pratama Karawang and the Tax Center FE Singaperbangsa University Karawang carried out a 2023 tax volunteer service satisfaction survey with 3 (three) indicators assessment, namely assessment of attitudes/behavior with a value scale of 94.46%, assessment of understanding of taxation with a value scale of 94.10%, and assessment of communication skills with a value scale of 94.46%. The survey results show that respondents are very satisfied with the services provided by tax volunteers in helping individual taxpayers to submit annual tax returns.

 

Abstrak. Sebagian wajib pajak belum memahami cara pengoperasian e-filing karena berbagai fitur dan menu yang terkesan rumit. Oleh karena itu, pendampingan pengisian dan pelaporan SPT Tahunan diperlukan guna membantu wajib pajak orang pribadi dalam mengoperasikan e-filing untuk menyampaikan SPT Tahunan. Metode yang diterapkan dalam pengabdian ini adalah pendampingan pengisian dan pelaporan SPT tahunan kepada WPOP yang terletak di daerah Karawang dengan 3 (tiga) tahap pelaksanaan, yaitu tahap bimbingan teknis, tahap pelaksanaan asistensi, dan tahap evaluasi. Sekitar 4.102 wajib pajak yang mendapat pendampingan dari tim relawan pajak untuk menyampaikan SPT 1770SS dan SPT 1770S. Asistensi ini dilakukan secara luring yang dilaksanakan selama 2 (dua) bulan yaitu Februari dan Maret 2023. Untuk mengukur keberhasilan dari pelaksanaan asistensi ini, KPP Pratama Karawang dan Tax Center FE Universitas Singaperbangsa Karawang melaksanakan survei kepuasan layanan relawan pajak 2023 dengan 3 (tiga) indikator penilaian, yaitu penilaian terhadap sikap/tingkah laku dengan skala nilai 94,46%, penilaian terhadap pemahaman perpajakan dengan skala nilai 94,10%, dan penilaian terhadap kemampuan komunikasi dengan skala nilai 94,46%. Hasil survei tersebut menunjukkan bahwa responden sangat puas dengan pelayanan yang diberikan oleh relawan pajak dalam membantu wajib pajak orang pribadi untuk menyampaikan SPT Tahunan.

 

 
From Trenches to the Crest, effectuating a Greater Beneficence of Terminology Development to National Language Policy: the Nigeria Case
Authors: C. I. C Cardinal,
Published: February 2024

Terminology development as a tool that propels the evolvement of educational and translation materials and services besides enhancing the formation of a robust terminology is widely celebrated as a great linguistic tool. This is because of its’ potency in knitting together a multilingual society like Nigeria towards a common understanding and purpose. The afore-stated promotion of national unity, effective communication and the preservation of indigenous languages directed towards the creation of an inclusive nation are the same goals pursued by the National Policy on Education which couches Nigeria’s Language Policy. Consequently, this study titled, ‘From Trenches to the Crest, effectuatinga Greater Beneficence of Terminology Development to National Language Policy: The Nigeria Case’, primarily aims to explore the meritorious services of terminology development in the evolution, realization and implementation of an effective language policy in Nigeria. By surveying the historical development of Nigeria language policy, it identifies and condemns the overemphasis of the usage of English language for instructional and legislative purposes, pointing out its disservices to indigenous languages. The study also highlights the fundamental roles and challenges impeding a fuller beneficence of a symbiosis of terminology development and the National Language Policy in achieving national integration. Adopting the hermeneutical and content analysis methods of enquiry, the research in conclusion, suggests a novel pragmatic and proactive terminology development model, which will drive a vibrant language policy and implementation.
Creating a trauma- informed culture: Practicality in schools
Authors: Shoko Ratidzai
Published: February 2024

Traumatic life experiences have an impact on learning, behaviour, and relationships in schools. A trauma-informed culture instilled in schools could significantly reduce the effects of traumatic experiences on learners, however, creating this may present challenges in schools. This article used secondary data from scholarly articles to investigate the practicality of creating a trauma- informed culture in schools. It was found that fostering a trauma-informed culture in educational settings is challenging since there are not enough qualified teachers or resources, and some activities cannot be done during school hours. It is recommended that proper training be provided to the educators and enough resources be availed to enable proper creation of a trauma- informed culture in schools.
Encoding prior knowledge in ensemble refinement
Authors: Köfinger Jürgen , Hummer Gerhard
Published: February 2024

The proper balancing of information from experiment and theory is a long-standing problem in the analysis of noisy and incomplete data. Viewed as a Pareto optimization problem, improved agreement with the experimental data comes at the expense of growing inconsistencies with the theoretical reference model. Here, we propose how to set the exchange rate a priori to properly balance this trade-off. We focus on gentle ensemble refinement, where the difference between the potential energy surfaces of the reference and refined models is small on a thermal scale. By relating the variance of this energy difference to the Kullback-Leibler divergence between the respective Boltzmann distributions, one can encode prior knowledge about energy uncertainties, i.e., force-field errors, in the exchange rate. The energy uncertainty is defined in the space of observables and depends on their type and number, and on the thermodynamic state. We highlight the relation of gentle refinement to free energy perturbation theory. A balanced encoding of prior knowledge increases the quality and transparency of ensemble refinement. Our findings extend to non-Boltzmann distributions, where the uncertainty in energy becomes an uncertainty in information.
When Do Quantum Mechanical Descriptors Help Graph Neural Networks Predict Chemical Properties?
Authors: Li Shih-Cheng , Wu Haoyang , Menon Angiras , Spiekermann Kevin , Li Yi-Pei , Green William
Published: February 2024

Deep graph neural networks are extensively utilized to predict chemical reactivity and molecular properties. However, because of the complexity of chemical space, such models often have difficulty extrapolating beyond the chemistry contained in the training set. Augmenting model with quantum mechanical (QM) descriptors is anticipated to improve its generalizability. However, obtaining QM descriptors often requires CPU-intensive computational chemistry calculations. To identify when QM descriptors help graph neural networks predict chemical properties, we conduct a systematic investigation of the impact of atom, bond, and molecular QM descriptors on the performance of directed message passing neural networks (D-MPNNs) for predicting 16 molecular properties. The analysis surveys computational and experimental targets, classification and regression tasks, and varied dataset sizes from several hundred to hundreds of thousands of datapoints. Our results indicate that QM descriptors are mostly beneficial to D-MPNN performance on small datasets, provided that the descriptors correlate well with the targets and can be readily computed at high accuracy. Otherwise, using QM descriptors can add cost without benefit or even introduce unwanted noise that can degrade model performance. Strategic integration of QM descriptors with D-MPNN unlocks potential for physics-informed, data-efficient modeling with some interpretability that can streamline de novo drug and material designs. To facilitate the use of QM descriptors in machine learning workflows for chemistry, we provide a set of guidelines regarding when and how to best leverage QM descriptors, a high-throughput workflow to compute them, and an enhancement to Chemprop, a widely adopted open-source D-MPNN implementation for chemical property prediction.
A straightforward method to prevent the under-estimated problem of aspartimide formation during chemical ligation-mediated protein synthesis
Authors: Cisse El hadji , Aucagne Vincent
Published: February 2024

Formation of a five-membered ring aspartimide through the attack of a backbone amide to the side chain of aspartate and asparagine residues is a long-known side-reaction in solid phase peptide synthesis, and is also associated with in vivo protein ageing and instability of purified proteins. Conversely, its possible occurrence during chemical ligation-based protein synthesis, in particular when using the gold-standard reaction NCL (native chemical ligation), is dubious. We herein report a systematic study which demonstrates that the prevalence of this side-reaction may have been overlooked, due to the difficulty to identify it through standard HPLC analytical methods, but also the in situ conversion of aspar-timide into other byproducts, having the same molecular mass as the parent aspartate residue. We show that the for-mation of aspartimide and related byproducts can be limited by adopting "good NCL practices", which involve restricting the ligation temperature and reaction times, as well as replacing the commonly used phosphate buffer with HEPES. How-ever, the efficiency of such precautions is expected to vary considerably depending on the sequence of the target protein, and the amount of byproducts is expected to grow with the length of the target protein, as a result of the number of NCL reactions and potential aspartimide hotspots. To overcome such limitations, we developed a novel straightforward and potentially generally applicable methodology based on the temporary protection of the backbone nitrogen by a 2-(4-aminobutanoyloxy)-4-methoxybenzyl (GABA-Hmb) group. This strategy was validated by the byproduct-free synthesis of SUMO-2 and a SUMOylated peptide mimic.
Erastin-like anti-Warburg compounds X1 and X4 are GLS2-selective covalent glutaminase inhibitors
Authors: Crane Clea , Miele Morgan , Iyengar Ranjini , Strathmann Noah , Jallow Sainabou , Ulrich Scott
Published: February 2024

The Warburg effect is a metabolic alteration in cancer cells characterized by aerobic glycolysis and lactate production. A recent phenotypic screen for compounds that reverse Warburg metabolism identified two compounds, X1 and X4, that restore the mitochondrial membrane potential, decrease lactate production, and increase the level of reactive oxygen species in cancer cells. Here we show that X1 and X4 are GLS2-selective covalent glutaminase inhibitors. Glutaminase enzymes hydrolyze glutamine to glutamate, which supports cancer cell metabolism through TCA cycle anaplerosis and glutathione biosynthesis. The GLS1 glutaminase isozyme has well-established roles in cancer cell metabolism. Conversely, GLS2 is an enigmatic enzyme with reported roles in both tumor promotion and tumor suppression and remains an underdeveloped drug target. This finding suggests roles for GLS2 in supporting Warburg metabolism and managing oxidative stress in cancer cells. X1 and X4 may accelerate the development of high-quality inhibitors of GLS2 to clarify its unique roles in cancer cell metabolism.
The Lewis Structure explorer: Accessible by Design
Authors: Wegwerth Sarah E. , Urrea Alexa , Nischik Debra R. , Winter Julia E.
Published: February 2024

Successfully learning principles from drawing Lewis Structures sets the foundation for understanding more complex representations of chemical concepts. As these visual-based concepts are core competencies in chemical pedagogies, it is incumbent and required for educational institutions and faculty to provide usable accommodations for all students, including those with blindness and low-vision (BLV). The shift to visually based interactive digital media increases the technical challenge for addressing accessibility for BLV students and makes creating these accommodations by faculty even more difficult. This technology report presents research and development for providing a digital learning system for Lewis Structures designed to be directly accessible by BLV students and other screen reader users. This Lewis Structure explorer can be used by all students and includes a form-driven keyboard accessible control panel. The alternative (alt) text for the structural representations is generated dynamically with user input. The results from two usability studies, one with over 300 sighted college students and the other with four BLV adults who depend on alt text for non-text information, are presented.