bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on microwave ablation temperature prediction model based on grayscale ultrasound texture and machine learning
Authors: Xiong Yan , Zheng Yi , Long Wei , Wang Yuxin , Wang Qin , You Yi , Zhou Yuheng , Zhong Jiang , Ge Yunxi , Li Youchen , Huang Yan , Zhou Zhiyong
Published: September 2024

Background

Temperature prediction is crucial in the clinical ablation treatment of liver cancer, as it can be used to estimate the coagulation zone of microwave ablation.

Methods

Experiments were conducted on 83 fresh ex vivo porcine liver tissues at two ablation powers of 15 W and 20 W. Ultrasound grayscale images and temperature data from multiple sampling points were collected. The machine learning method of random forests was used to train the selected texture features, obtaining temperature prediction models for sampling points and the entire ultrasound imaging area. The accuracy of the algorithm was assessed by measuring the area of the hyperechoic area in the porcine liver tissue cross-section and ultrasound grayscale images.

Results

The model exhibited a high degree of accuracy in temperature prediction and the identification of coagulation zone. Within the test sets for the 15 W and 20 W power groups, the average absolute error for temperature prediction was 1.14°C and 4.73°C, respectively. Notably, the model’s accuracy in measuring the area of coagulation was higher than that of traditional ultrasonic grey-scale imaging, with error ratios of 0.402 and 0.182 for the respective power groups. Additionally, the model can filter out texture features with a high correlation to temperature, providing a certain degree of interpretability.

Conclusion

The temperature prediction model proposed in this study can be applied to temperature monitoring and coagulation zone range assessment in microwave ablation.
On human nanoscale synaptome: Morphology modeling and storage estimation
Authors: Nowinski Wieslaw L.
Published: September 2024

One of the key challenges in neuroscience is to generate the human nanoscale connectome which requires comprehensive knowledge of synaptome forming the neural microcircuits. The synaptic architecture determines limits of individual mental capacity and provides the framework for understanding neurologic disorders. Here, I address morphology modeling and storage estimation for the human synaptome at the nanoscale. A synapse is defined as a pair of pairs [(presynaptic_neuron),(presynaptic_axonal_terminal);(postsynaptic_neuron),(postsynaptic_dendritic_terminal)]. Center coordinates, radius, and identifier characterize a dendritic or axonal terminal. A synapse comprises topology with the paired neuron and terminal identifiers, location with terminal coordinates, and geometry with terminal radii. The storage required for the synaptome depends on the number of synapses and storage necessary for a single synapse determined by a synaptic model. I introduce three synaptic models: topologic with topology, point with topology and location, and geometric with topology, location, and geometry. To accommodate for a wide range of variations in the numbers of neurons and synapses reported in the literature, four cases of neurons (30;86;100;138 billion) and three cases of synapses per neuron (1,000;10,000;30,000) are considered with three full and simplified (to reduce storage) synaptic models resulting in total 72 cases of storage estimation. The full(simplified) synaptic model of the entire human brain requires from 0.21(0.14) petabytes (PB) to 28.98(18.63) PB for the topologic model, from 0.57(0.32) PB to 78.66(43.47) PB for the point model, and from 0.69(0.38) PB to 95.22(51.75) PB for the geometric model. The full(simplified) synaptic model of the cortex needs from 86.80(55.80) TB to 2.60(1.67) PB for the topologic model, from 235.60(130.02) TB to 7.07(3.91) PB for the point model, and from 285.20(155.00) TB to 8.56(4.65) PB for the geometric model. The topologic model is sufficient to compute the connectome’s topology, but it is still too big to be stored on today’s top supercomputers related to neuroscience. Frontier, the world’s most powerful supercomputer for 86 billion neurons can handle the nanoscale synaptome in the range of 1,000–10,000 synapses per neuron. To my best knowledge, this is the first big data work attempting to provide storage estimation for the human nanoscale synaptome.
Improvement of esophageal cancer survival in Northeast Iran: A two-decade journey in a high-risk, low- resource region
Authors: Nemati Saeed , Islami Farhad , Kamangar Farin , Poustchi Hossein , Roshandel Gholamreza , Shakeri Ramin , Domingues Allison , Khoshnia Masoud , Gharavi Abdolsamad , Brennan Paul , Abnet Christian C. , Dawsey Sanford M. , Boffetta Paolo , Malekzadeh Reza , Sheikh Mahdi
Published: September 2024

Background and objective

Two decades ago, an international initiative (GEMINI) was launched in a high-risk, low-resource region in Northeast Iran, aiming to investigate incidence, etiology, early detection, and treatment of esophageal squamous cell carcinoma (ESCC). An earlier report from this area, highlighted poor ESCC survival rates, with a 5-year survival probability of 3.3% and the median survival time of 7 months. Our study assesses whether ESCC survival has improved since the implementation of the GEMINI initiative in this region.

Material and methods

490 adult patients with histologically-confirmed ESCC were recruited from the Atrak clinic, Golestan, Iran, between 2007 and 2018. At recruitment, information on demographics and various exposures were collected. Active (telephone surveys) and passive (linkage to Golestan population-based cancer and death registries) follow-up methods were used to determine patients’ vital status though March 2019. Survival estimates were obtained by Kaplan-Meier method and Cox proportional hazards regression models.

Results

Over the study period 340 deaths were recorded. Five-year ESCC survival probability was 23% (95% Confidence Interval: 19% to 28%), and the median survival time was 19 months. Five-year survival probability was higher among individuals who were younger (35% in <60-year-olds vs. 12% for >70-year-olds, p<0.001), educated (34% vs. 21% for no formal education, p = 0.027), never used opium (28% vs. 15%, p = 0.0016), and received cancer treatment (37% vs. 4%, p<0.001). In the adjusted models, a higher hazard of death was associated with older age [HR for each 10-year increase = 1.36 (95% CI = 1.22 to 1.51)], Turkman ethnicity [HR = 1.35 (95%CI: 1.07 to 1.70)], opium use [HR = 1.53 (95%CI: 1.20 to 1.94)],and receiving no cancer treatment [HR = 5.81 (95%CI: 3.97 to 8.52)].

Conclusion

Over the last two decades, ESCC survival in this population has significantly improved, highlighting the potential of enhancing healthcare infrastructure and ensuring access to affordable medical care in resource-limited, high-risk regions. Older age at diagnosis, Turkman ethnicity, opium use, and untreated cases (indicative of advanced disease at diagnosis) were identified as the main ESCC prognostic factors in this population.
Prevalence of offering menopause hormone therapy among primary care doctors and its associated factors: A cross-sectional study
Authors: Low Tiong Lim , Cheong Ai Theng , Devaraj Navin Kumar , Ismail Rohayah
Published: September 2024

Background

Guidelines recommend Menopausal Hormone Therapy (MHT) as the most effective treatment for menopausal symptoms. However, a local study found that the usage of MHT among menopausal women was low (8.1%), with one of the main reasons being it is not recommended by doctors. Therefore, the objectives of this study are to determine the prevalence of offering MHT in treating symptomatic menopausal women among primary care doctors (PCDs) and its associated factors.

Methods

This cross-sectional study involved PCDs from the Federal Territory of Kuala Lumpur, the Federal Territory of Putrajaya and the state of Selangor. All PCDs provided services in government primary care clinics from the three states were invited through the doctor in charge of each clinic. An online survey links was provided for the participants to the self-administered questionnaire. The questionnaire included PCDs’ demographics, their menopause management practices, attitudes towards MHT, perceived barriers in offering MHT, knowledge of related guidelines and received training on menopause management. The outcome variable was offering MHT which defined as either prescription of MHT or referral to hospital for MHT initiation. Multivariate logistic regression analysis was performed to determine the factors associated with offering MHT.

Results

The response rate was 42.9% (559/1301). Of those who participated in the study, 77.8% of PCDs were female and 89.1% were medical officer. Although 66.9% of the participants reported offering MHT to their patients, the actual prescription rate was low (0.9%). Most PCDs (66%) would refer the patients to hospitals. 87.1% of PCDs (487/559) reported that MHT was not available in their clinic. In the past 12 months, 83% of PCDs had not received any related training. Female PCDs (AOR:2.5, CI: 1.51–4.13, p<0.001), perceiving MHT as preference treatment for menopause symptom (AOR:3.6, CI: 2.13–6.19, p < 0.001), having likelihood to recommend MHT to family and friends (AOR:3.0, CI: 1.87–4.83, p < 0.001), and receiving training on menopause management (AOR:2.7, CI: 1.30–5.56, p = 0.008) were the positive predictor of offering MHT. The negative predictors in offering MHT were no-experience in prescribing MHT (AOR: 0.4, CI: 0.15–0.87, p = 0.024) and lack of information regarding MHT for the patient (AOR: 0.4, CI:0.20–0.67, p < 0.001).

Conclusion

The study revealed a low rate of MHT prescription among PCDs, with many relying on referrals to hospitals for managing menopausal symptoms. The findings underscore the need for strategies that includes fulfilling professional training gaps, improving MHT availability, and improving information dissemination for patient.
Ultrastructural changes in cardiac and skeletal myoblasts following in vitro exposure to monensin, salinomycin, and lasalocid
Authors: Henn Danielle , Lensink Antonia V. , Botha Christo J.
Published: September 2024

Carboxylic ionophores are polyether antibiotics used in production animals as feed additives, with a wide range of benefits. However, ionophore toxicosis often occurs as a result of food mixing errors or extra-label use and primarily targets the cardiac and skeletal muscles of livestock. The ultrastructural changes induced by 48 hours of exposure to 0.1 μM monensin, salinomycin, and lasalocid in cardiac (H9c2) and skeletal (L6) myoblasts in vitro were investigated using transmission electron microscopy and scanning electron microscopy. Ionophore exposure resulted in condensed mitochondria, dilated Golgi apparatus, and cytoplasmic vacuolization which appeared as indentations on the myoblast surface. Ultrastructurally, it appears that both apoptotic and necrotic myoblasts were present after exposure to the ionophores. Apoptotic myoblasts contained condensed chromatin and apoptotic bodies budding from their surface. Necrotic myoblasts had disrupted plasma membranes and damaged cytoplasmic organelles. Of the three ionophores, monensin induced the most alterations in myoblasts of both cell lines.
Molecular mechanism and structure-guided humanization of a broadly neutralizing antibody against SFTSV
Authors: Yang Pinyi , Wu Xiaoli , Shang Hang , Sun Zixian , Wang Zhiying , Song Zidan , Yuan Hong , Deng Fei , Shen Shu , Guo Yu , Zhang Nan
Published: September 2024

Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel tick-borne bunyavirus that causes severe fever with thrombocytopenia syndrome (SFTS), with a high mortality rate of up to 30%. The envelope glycoproteins of SFTSV, glycoprotein N (Gn) and glycoprotein C (Gc), facilitate the recognition of host receptors and the process of membrane fusion, allowing the virus to enter host cells. We previously reported a monoclonal antibody, mAb 40C10, capable of neutralizing different genotypes of SFTSV and SFTSV-related viruses. However, the specific neutralization mechanism is poorly understood. In this study, we elucidated the high-resolution structure of the SFTSV Gn head domain in complex with mAb 40C10, confirming that the binding epitope in the domain I region of SFTSV Gn, and it represented that a novel binding epitope of SFTSV Gn was identified. Through in-depth structural and sequence analyses, we found that the binding sites of mAb 40C10 are relatively conserved among different genotypes of SFTSV and SFTSV-related Heartland virus and Guertu virus, elucidating the molecular mechanism underlying the broad-spectrum neutralizing activity of mAb 40C10. Furthermore, we humanized of mAb 40C10, which is originally of murine origin, to reduce its immunogenicity. The resulting nine humanized antibodies maintained potent affinity and neutralizing activity. One of the humanized antibodies exhibited neutralizing activity at picomolar IC50 values and demonstrated effective therapeutic and protective effects in a mouse infection model. These findings provide a novel target for the future development of SFTSV vaccines or drugs and establish a foundation for the research and development of antibody therapeutics for clinical applications.
Perspectives on popular music voice teaching: A systematic mapping review of recent literature
Authors: Keskinen Katri A. , Juntunen Marja-Leena
Published: September 2024

This systematic mapping review explored scholarly and educational literature on popular music voice teaching (PMVT) published in English, Finnish and Swedish between 2014 and 2020. The mapping included 177 publications, including peer-reviewed articles, book chapters, dissertations and educational books. The literature was categorized into four so-called dispositions, the findings suggesting that PMVT is perceived either as an independent field of work or as part of the broader disciplines of voice teaching (VT) or instrument teaching. The literature was also organized into seven key areas and 33 topics, encompassing disciplinary issues, education, genre-specific singing, pedagogical methods and tools, voice students, voice science, and health and well-being. The analysis highlights the influence of author context and acknowledges an English-language bias, resulting in an Anglo-American emphasis in the reviewed literature.
Decolonizing stylistic awareness in higher education contemporary commercial music training: Exploring performer–practitioner experiences through an Africentric approach
Authors: Smith-Whicker Tessa , Brown Jenna
Published: September 2024

This research explores decolonization within higher education contemporary commercial music (CCM) training. It considers how stylistic awareness can be developed in practice, using an Africentric theoretical approach, ensuring voices with the most cultural insight in CCM are elevated. Africentric methodology guides triangulated methods, comprising literature review, document analysis and interviews. Findings indicate stylistic awareness is difficult to objectively measure, despite being vital for culturally viable and creative CCM performance. Cultivating stylistic awareness relies on influences from individuals’ past and present, through individual and community-based experiences. Pedagogical strategies for student-led, decolonized exploration of stylistic awareness are presented and further areas for research are outlined.
The technologically mediated voice: Captured and processed contemporary singing
Authors: Hughes Diane , Knowles Julian
Published: September 2024

The mediated singing voice is a significant consideration for contemporary singers in both live performance and recording contexts. Developments in technologies have enabled progressive adjustments in the delivery of the singing voice (e.g. crooning) and, more specifically, in the ways in which the singing voice may be captured and communicated. Using this as a starting point for mediated singing, the article provides an approach to learning, implementing and teaching audio technologies for contemporary singers. We adopt a collaborative approach in which we (self)reflect, analyse and consolidate our respective experiences and through which we identify numerous points of mediation as vocals are processed. Our inquiry focuses on specific areas including mediated voice, aesthetics, recording and performance considerations, and vocal care strategies. Cumulatively, our findings and discussion lead to development of a pedagogical framework for teaching the contemporary singing voice that accounts for its association with audio technology.
Editors’ introduction to the Special Issue on CCM voice
Authors: Powell Bryan , Smith Gareth Dylan
Published: September 2024

In this Special Issue, the authors describe the popular music education landscape in and from which practice and theory of contemporary commercial music (CCM) voice studies have emerged. They contextualize the discipline within the history of conferences of the Association for Popular Music Education before outlining the article content from all contributing authors.
Análisis macroestructural semántico del discurso de la prensa latinoamericana digital sobre los ataques del 11 de septiembre
Authors: Martínez Vizcarrondo Doris E.
Published: September 2024

Este artículo analiza la exclusión e inclusión de acontecimientos y actores sociales en la representación de los sucesos del 11 de septiembre en Nueva York en la prensa digital latinoamericana. Se utiliza el análisis crítico del discurso siguiendo los principios establecidos por Van Dijk (1990, 1997, 1998). La muestra está conformada por 509 noticias seleccionadas de la cobertura noticiosa de diecisiete periódicos digitales latinoamericanos, desde el 12 hasta el 16 de septiembre. Entre los resultados destacan: a.) los contenidos de los periódicos examinados reproducen el discurso de las agencias de noticias estadounidenses; b.) Los tópicos reflejan un discurso sin referencia al pasado, sin reflexión sobre las causas de los acontecimientos y los responsables, táctica cuyo objetivo es minimizar las contradicciones y la identificación y los agentes de los hechos. c.) los tópicos seleccionados son producto de opiniones, ideologías y valores que proceden de las ideologías de las elites militares, políticas, periodísticas estadounidenses; d.) la construcción de identidades se establece mediante una dicotomía: un “Yo-Nosotros”, Estados Unidos-América Latina, la sociedad con valores positivos (legalidad, moderación) y un “Él-Ellos-Otro”, los árabes, los afganos representantes de los valores rechazados por la sociedad (extremistas, ilegales).
Cruzando fronteras: tiempo, espacio y desorientación en la narrativa
Authors: Fina Anna de
Published: September 2024

En este artículo examino la construcción del tiempo y el espacio como elementos de orientación en narraciones que tratan sobre experiencias que desorientan. Me enfoco en cómo los narradores articulan la orientación y cómo quienes los escuchan interactúan con ellos para entender los eventos narrados. Sostengo que el manejo de la orientación en la narración de historias ilustra cómo el uso de recursos lingüísticos conecta a los narradores e interlocutores con contextos sociales macro y micro. Sugiero además que considerar el papel que juega la orientación en diferentes tipos de narraciones tiene dos importantes consecuencias metodológicas: lleva a los analistas a mirar con ojo crítico las nociones ya existentes sobre la estructura de la narración y abre nuevas vertientes para el análisis de las múltiples conexiones entre las narraciones y los contextos sociales. Los fenómenos analizados incluyen: falta de precisión al ofrecer detalles de orientación, negociación sobre orientación durante la interacción, predominio de orientación espacial sobre la temporal en ciertas narraciones o secciones narrativas, y uso de convenciones compartidas para narrar la experiencia de cruzar la frontera. Los datos utilizados en el artículo proceden de 13 crónicas sobre el cruce de la frontera que fueron narrados durante entrevistas sociolingüísticas por inmigrantes mexicanos indocumentados en los Estados Unidos.
A representação da infância em situação de rua na literatura de cordel brasileira: uma análise discursiva crítica
Authors: Resende Viviane de Melo
Published: September 2024

Este trabalho resulta de uma pesquisa visando à análise dos modos como a Literatura de Cordel legitima ou questiona a lógica neoliberal de demissão do Estado e o conseqüente agravamento da precariedade social e da apartação na sociedade brasileira. Para tanto, a Análise de Discurso Crítica foi adotada para análise lingüístico-discursiva de um folheto de cordel sobre o tema. O folheto foi analisado na perspectiva de seu significado representacional, por meio da abordagem do significado que a expressão ‘meninos de rua’ assume no texto. A Etnografia foi utilizada como método complementar à Análise de Discurso Crítica, tanto para uma maior compreensão das práticas discursiva e social envolvidas na produção de cordel quanto para o embasamento da análise lingüístico-discursiva. Foram entrevistados atores sociais envolvidos com a produção de cordel, inclusive a autora do folheto analisado. Os resultados da pesquisa apontam a internalização de discursos que sustentam a percepção fatalista da globalização neoliberal no cordel, o que serve para evidenciar como a circulação massiva dessas representações em variados tipos de texto é parte importante da hegemonia. Isso porque o texto analisado, evidentemente, não objetiva a legitimação do neoliberalismo e da apartação, mas, pela internalização desses discursos, muitas vezes acaba por fazê-lo.
La enseñanza y cultura del español casero. Entendiendo la reproducción racista en el discurso ‘doméstico’
Authors: Schwartz Adam
Published: September 2024

Inspirado por el trabajo de Hill sobre los usos del español entre angloamericanos (1993, 1994, 1998, 2005), este artículo expone el ‘español casero’ como un sitio discursivo para la reproducción de racismo y orden social. También conocido como discurso ‘doméstico,’ este uso del español consiste mayormente de directivos unidireccionales utilizados por anglohablantes de clase media y alta (dueños de viviendas) que se intentan ‘comunicar’ con sus empleados domésticos y jardineros. Por muchos años se ha enseñado y vendido este discurso doméstico por medio de textos de bolsillo, los cuales son tremendamente apreciados por su brevedad y accesibilidad por los muy ocupados dueños de casa. El autor investiga uno de tales textos que es tan popular que se ha sido republicado. Un análisis crítico de Household Spanish (El español casero) de Harvey (1995/2005) intenta proveer una introducción a la enseñanza y cultura de discurso doméstico, incluyendo un resumen histórico de la fuerza de trabajo doméstica hispanohablante de EEUU. Discusiones en torno a la indexicalidad y la elevación de la blancura racial siguen, además de un por supuesto análisis discursivo de ejemplos específicos del español casero.
Lupicinio Íñiguez (coordenador) Manual de Análise do Discurso em Ciências Sociais. Petrópolis/Rio de Janeiro. Vozes. 2005. 2ª edição. 312 págs. ISBN 85.326.3004-9
Authors: Meneghel Stela Nazareth
Published: September 2024

Lupicinio Íñiguez (coordenador) Manual de Análise do Discurso em Ciências Sociais. Petrópolis/Rio de Janeiro. Vozes. 2005. 2ª edição. 312 págs. ISBN 85.326.3004-9.
Ricard Zapata-Barrero y Teun A. van Dijk (eds.). Discursos sobre la inmigración en España. Los medios de comunicación, los parlamentos y las administraciones. Barcelona: Fundación Cidob. 2007. 272 p. ISBN 978-84-87072-78-9.
Authors: Ridao Rodrigo Susana
Published: September 2024

Ricard Zapata-Barrero y Teun A. van Dijk (eds.). Discursos sobre la inmigración en España. Los medios de comunicación, los parlamentos y las administraciones. Barcelona: Fundación Cidob. 2007. 272 p. ISBN 978-84-87072-78-9.
A Potential Biomarker for Treatment Response in Triple-negative Breast Cancer
Authors:   Sunvalley Communication, LLC / Onco'Zine, Hofland Peter
Published: September 2024

New insights into tumor-induced B-cell changes in blood and bone marrow of triple-negative breast cancer (TNBC) patients show two distinct patterns of B-cell abnormalities that could serve as biomarkers for determining the likelihood of response to standard-of-care chemotherapy (SoC) and immunotherapy.
Posterior subependymal germinal matrix hemorrhage as a mild form of hemorrhage in extremely preterm infants: neurodevelopmental outcomes at corrected ages of 18-24 months
Authors: Koo Jae Mo , Yoo So-Young , Kim Ji Hye , Park Ji Eun , Baek Sun-Young , Jeon Tae Yeon
Published: September 2024

Purpose: This study aimed to explore the effects of both the presence and size of posterior subependymal germinal matrix hemorrhage (PS-GMH), considered a mild form of hemorrhage, on the neurodevelopmental outcomes of extremely preterm infants.Methods: A retrospective analysis was conducted on 221 extremely preterm infants, assessing their initial and term-equivalent age (TEA) cranial ultrasound (cUS) examinations from 2016 to 2021. Infants were classified based on the presence and size (small/large) of PS-GMH. Neurodevelopmental outcomes at corrected ages of 18-24 months were analyzed in 135 infants.Results: PS-GMH was identified in 86.9% (192/221) of the infants, with 13.5% (26/192) exhibiting large PS-GMH. Among the 135 infants who were followed up, those with PS-GMH were found to have younger gestational ages (P<0.001) and a higher incidence of maternal chorioamnionitis (P=0.016) than those without PS-GMH. Significant differences were observed in the incidence of grade II intraventricular hemorrhage (IVH) on initial cUS (P=0.003) and ventriculomegaly at TEA cUS (P=0.026) across the groups with no PS-GMH, small PS-GMH, and large PS-GMH. The large PS-GMH group exhibited a higher occurrence of grade II IVH than the small PS-GMH group (P=0.006). However, ventriculomegaly incidence did not significantly vary with PS-GMH status. Neurodevelopmental outcomes were also not significantly different across PS-GMH statuses. The adjusted odds ratios for any neurodevelopmental impairment, compared to the no PS-GMH group, were 1.70 (95% confidence interval [CI], 0.40 to 7.26; P=0.471) for all PS-GMH, 1.61 (95% CI, 0.37 to 6.93; P=0.526) for small PS-GMH, and 3.84 (95% CI, 0.62 to 24.00; P=0.150) for large PS-GMH.Conclusion: PS-GMH was frequently observed in extremely preterm infants; however, it did not independently predict adverse neurodevelopmental outcomes.
Analisis Performa Normalisasi Data untuk Klasifikasi K-Nearest Neighbor pada Dataset Penyakit
Authors: Allorerung Petronilia Palinggik , Erna Angdy , Bagussahrir Muhammad , Alam Samsu
Published: September 2024

This study investigates four normalization methods (Min-Max, Z-Score, Decimal Scaling, MaxAbs) across prostate, kidney, and heart disease datasets for K-Nearest Neighbor (K-NN) classification. Imbalanced feature scales can hinder K-NN performance, making normalization crucial. Results show that Decimal Scaling achieves 90.00% accuracy in prostate cancer, while Min-Max and Z-Score yield 97.50% in kidney disease. MaxAbs performs well with 96.25% accuracy in kidney disease. In heart disease, Min-Max and MaxAbs attain accuracies of 82.93% and 81.95%, respectively. These findings suggest Decimal Scaling suits datasets with few instances, limited features, and normal distribution. Min-Max and MaxAbs are better for datasets with numerous instances and non-normal distribution. Z-Score fits datasets with a wide range of feature numbers and near-normal distribution. This study aids in selecting the appropriate normalization method based on dataset characteristics to enhance K-NN classification accuracy in disease diagnosis. The experiments involve datasets with different attributes, continuous and categorical data, and binary classification. Data conditions such as the number of instances, the number of features, and data distribution affect the performance of normalization and classification.
Implementasi Data Augmentation untuk Klasifikasi Sampah Organik dan Non Organik Menggunakan Inception-V3
Authors: Bintang Rahina , Azhar Yufis
Published: September 2024

The surge in global waste, particularly in Indonesia, with a total of 36.218 million tons per year, has become an urgent issue. Challenges in waste management are increasingly complex due to the lack of public understanding and awareness in classifying types of waste. One systemic approach to address waste classification issues involves the use of machine learning technology to categorize waste into two main types: organic and non-organic. The data used in this study comes from a Kaggle website dataset comprising 25,500 entries. This research employs a transfer learning approach with the Inception-V3 architecture and data augmentation implementation. Transfer learning is chosen for its proven performance in image data classification, while data augmentation is implemented to introduce diversity to the dataset. The research stages include business understanding, data preprocessing, data augmentation, data modelling, and evaluation. The results show that the use of transfer learning with the Inception-V3 approach and data augmentation implementation achieves an accuracy rate of 94%, which falls into the excellent category.
Implementasi K-Means Clustering pada Pengelompokan Pasien Penyakit Jantung
Authors: Wala Jihan , Herman Herman , Umar Rusydi
Published: September 2024

Heart disease is a prominent global health concern, necessitating early identification and patient grouping for effective management. This study employs the K-Means clustering algorithm with a medical dataset of 303 patients, encompassing various attributes. These include Age, Gender, Chest Pain Type, Blood Pressure, Serum Cholesterol Level, Fasting Blood Sugar, Resting Electrocardiographic Results, Maximum Heart Rate, Angina, ST Depression, and Slope of the ST Segment. The goal is to categorize patients into four clusters based on chest pain types, a crucial symptom indicating disease severity. The computation concludes after the sixth iteration, revealing Cluster 1 (27 patients), Cluster 2 (135 patients), Cluster 3 (15 patients), and Cluster 4 (126 patients). Collaborative analysis with medical experts highlights that Cluster 1, mainly comprising older males, exhibits high-risk indicators. While this grouping aids in personalized treatment strategy development, further clinical validation involving more experts and datasets is imperative for enhanced reliability.
Pelabelan Sentimen Berbasis Semi-Supervised Learning menggunakan Algoritma LSTM dan GRU
Authors: Ayuningtyas Puji , Khomsah Siti , Sudianto Sudianto
Published: September 2024

In the sentiment analysis research process, there are problems when still using manual labeling methods by humans (expert annotation), which are related to subjectivity, long time, and expensive costs. Another way is to use computer assistance (machine annotator). However, the use of machine annotators also has the research problem of not being able to detect sarcastic sentences. Thus, the researcher proposed a sentiment labeling method using Semi-Supervised Learning. Semi-supervised learning is a labeling method that combines human labeling techniques (expert annotation) and machine labeling (machine annotation). This research uses machine annotators in the form of Deep Learning algorithms, namely the Long Short-Term Memory (LSTM) and Gated Recurrent Unit (GRU) algorithms. The word weighting method used in this research is Word2Vec Continuous Bag of Word (CBoW). The results showed that the GRU algorithm tends to have a better accuracy rate than the LSTM algorithm. The average accuracy of the training results of the LSTM and GRU algorithm models is 0.904 and 0.913. In contrast, the average accuracy of labeling by LSTM and GRU is 0.569 and 0.592, respectively.
The Role of the Spirit in Rohr’s Theological Anthropology
Authors: Fischer Ondřej
Published: September 2024

This introductory essay comments on the diversity of positions between theology and anthropology in Richard Rohr. It presents him as one who walks a delicate line between semantic fidelity to Christian doctrine and its impact (or lack thereof) on spiritual well-being of the people affected by the brokenness of the world. Spirituality, which reflects the complexity of life, has become an alternative to institutionally driven Christianity.
Personal Reflection on Rohr’s Influence on my Thought
Authors: Lane Belden
Published: September 2024

This paper describes Rohr’s shift from the traditional Trinitarian theology to a new concept of God. Rohr sees Christ as the mysterious essence of all things. The Trinity is an expression of the flowing nature of the Divine. Jesus, through his cross, allowed suffering to change him and the world, so that people could break out of the endless cycle of projecting pain elsewhere and be loved by the reality that surrounds them. The implications of this shift for spirituality are considered. People can live with constant prayer, meditation and practice of his words in his presence.
Liminality as a Principle of the Life of Christian Communities in the Reflections of Richard Rohr
Authors: Lazúr Ondrej
Published: September 2024

This article analyzes Richard Rohr’s reflections on the anthropological and pastoral significance of the liminality. Although we do not find among Rohr’s publications a book in which he specifi-cally addresses the context of liminality or the pastoral care of Chris-tian communities, these contents are recognizable within his publica-tions. In this paper, we pay attention to the concepts or authors that Rohr relies on when reflecting on liminality and its meaning. Thus, it seeks to systematically deepen the ideas and concepts related to his understanding of the potential of liminality within the life of Christian communities. The main aim is to highlight the significant anthropologi-cal and pastoral potential of the concept of liminality, which Rohr most explicitly addressed in the book Adam’s Return. The secondary aim is to differentiate the character of liminality in the context of Christian communities, which could remain misunderstood.
Impact of control release fertilizers on vegetative, gas exchange attributes and nutrient status of Philodendron erubescens
Authors: Shanthanu R  , Keisar Lourdusamy D  , Kavino M  , Chitra R  , Prabu P C  , Vanitha K
Published: September 2024

Philodendron erubescens, commonly known as the Red-leaf Philodendron or Blushing Philodendron, is a popular ornamental plant species belonging to the family Araceae. Due to the bright red colour, this species is one of the leading indoor plants in commercial market. The current study investigated the efficacy of controlled-release fertilizers (CRFs) in accelerating the growth of tissue-cultured Philodendron erubescens (Pink Princess) to commercial saleable size in a nursery setting. Two CRF treatments - Basacote high K 6 M + hydrospeed CaB-Max and organic CRF + hydrospeed CaB-Max were compared against control using conventional water-soluble fertilizer. Forty-five-day-old tissue-cultured plantlets were evaluated over 60 days for morphological parameters, root development, physiological responses and nutrient uptake. A CI-340 Handheld photosynthesis machine was employed to measure photosynthetic rate, transpiration rate and stomatal conductance. Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) was used for precise quantification of foliar macro- and micronutrient concentrations. Results demonstrated that Basacote high K 6 M + hydrospeed CaB-Max significantly outperformed both organic CRF + hydrospeed CaB-Max and the control in accelerating plant growth to commercial standards. Basacote high K 6 M + hydrospeed CaB-Max treated plants reached a mean height of 28.48 cm and spread of 27.09 cm after 60 days, approaching the target saleable size of 25 to 30 cm. Root morphology analysis using WinRHIZO software revealed enhanced root system development in Basacote high K 6 M + hydrospeed CaB-Max plants, indicating improved establishment. Physiological measurements showed higher photosynthetic rates (11.46 ?mol m?² s?¹), transpiration rates (1.32 mmol m?² s?¹) and stomatal conductance (30.97 mmol m?² s?¹) in Basacote high K 6 M + hydrospeed CaB-Max plants. ICP-MS analysis indicated superior nutrient uptake and accumulation in T1-treated plants, particularly for calcium, potassium, magnesium and iron. Strong positive correlations between physiological parameters and morphological traits suggest that enhanced nutrient availability from CRFs contributed to accelerated growth and improved plant quality. This study elucidates the potential of tailored CRF formulations to optimize the rapid establishment of tissue-cultured P. erubescens into marketable plants, offering valuable insights for commercial nursery production practices.
Entelechy of the Emanational Form: Zenon Fajfer’s Poems of Potentiality
Authors: Bazarnik Katarzyna
Published: September 2024

Zenon Fajfer’s introduced into poetry an original, interactive form called “the emanational poem,” in which the multilevel acrostic is generative of simultaneously coexisting dimensions of text. The poet has used it in several of his works to render simultaneity, visibility and invisibility, potentiality and actuality. The article discusses the emanational form in view of Aristotle’s concept of entelechy. Exploring affordances of the electronic and printed media, the author explicates how the potentiality for mobility and intertextuality can be actualised in Fajfer’s “Ars Poetica,” Spoglądając Przez Ozo- nową Dziurę, and Powieki, drawing attention to the role of the reader in this process. She mentions the aporetic tension between the principle of Aristotelian entelechy and postmodern concept of intertextuality, also referencing the relevance of Ned Rossiter’s network theory to the interpretation of Fajfer’s work. Focusing on  Powieki, a multimodal cycle of emanational poems, published as  a compound of the material book and the digital poems in the CD, the author postulates, following Pisarski (2014) and Marecki (2018), that it is an entelechy of the hypertext. Moreover, this richly hyperlinked cycle of poems can be seen as a rewriting of the Orphean katabasis. It invites contem- plation of a complex, multidimensional space that should be explored in “slow,” or close reading, which defies typical expectations of electronic literature audiences. Finally, it is argued that Fajfer’s print-born digital hypertexts activate potentialities entailed in the matter(iality) of the writing in both media, the old and the new.
Hepato‐splanchnic fluxes during exercise in patients with cirrhosis—a pilot study
Authors: Volianitis Stefanos , Secher Niels H. , Clemmesen Otto , Ott Peter , Nielsen Henning Bay
Published: September 2024

In cirrhotic patients, compromised hepatocyte function combined with disturbed hepatic blood flow could affect hepato‐splanchnic substrate and metabolite fluxes and exacerbate fatigue during exercise. Eight cirrhotic patients performed incremental cycling trials (3 × 10 min; at light (28 [19–37] W; median with range), moderate (55 [41–69] W), and vigorous (76 [50–102] W) intensity). Heart rate increased from 68 (62–74) at rest to 95 (90–100), 114 (108–120), and 140 (134–146) beats/min (P < 0.05), respectively. The hepatic blood flow, as determined by constant infusion of indocyanine green with arterial and hepatic venous sampling, declined from 1.01 (0.75–1.27) to 0.69 (0.47–0.91) L/min (P < 0.05). Hepatic glucose output increased from 0.6 (0.5–0.7) to 1.5 (1.3–1.7) mmol/min, while arterial lactate increased from 0.8 (0.7–0.9) to 9.0 (8.1–9.9) mmol/L (P < 0.05) despite a rise in hepatic lactate uptake. Arterial ammonia increased in parallel to lactate from 47.3 (40.1–54.5) to 144.4 (120.5–168.3) μmol/L (P < 0.05), although hepatic ammonia uptake increased from 19.5 (12.4–26.6) to 69.5 (46.5–92.5) μmol/min (P < 0.05). Among the 14 amino acids measured, glutamate was released in the liver, while the uptake of free fatty acids decreased. During exercise at relatively low workloads, arterial lactate and ammonia levels were comparable to those seen in healthy subjects at higher workloads, while euglycemia was maintained due to sufficient hepatic glucose production. The accumulation of lactate and ammonia may contribute to exercise intolerance in patients with cirrhosis.
Role of L‐type Ca2+‐channels in the vasorelaxing response to finerenone in arteries of human visceral adipose tissue
Authors: Schinzari Francesca , De Stefano Alessandro , Sica Giuseppe , Mettimano Marco , Cardillo Carmine , Tesauro Manfredi
Published: September 2024

Inadequate blood supply to the expanding adipose tissue (AT) is involved in the unhealthy AT remodeling and cardiometabolic consequences of obesity. Because of the pathophysiological role of upregulated mineralocorticoid receptor (MR) signaling in the complications of obesity, this study tested the vasoactive properties of finerenone, a nonsteroidal MR antagonist, in arteries of human AT. Arteries isolated from the visceral AT of obese subjects were studied in a wire myograph. Finerenone resulted in a concentration‐dependent relaxation of arteries precontracted with either the thromboxane‐A2 analog U46619, ET‐1, or high‐K+ solution; the steroidal MR antagonist potassium canrenoate, by contrast, did not relax arteries contracted with either U46619 or high‐K+ solution. Finerenone‐induced relaxation after precontraction with U46619 was greater in the arteries of obese versus nonobese subjects. Mechanistically, the vasorelaxing response to finerenone was not influenced by preincubation with the nitric oxide synthase inhibitor L‐NAME or by endothelium removal. Interestingly, finerenone, like the dihydropyridine Ca2+‐channel blocker nifedipine, relaxed arteries contracted with the L‐type Ca2+‐channel agonist Bay K8644. In conclusion, finerenone relaxes arteries of human visceral AT, likely through antagonism of L‐type Ca2+ channels. This finding identifies a novel mechanism by which finerenone may improve AT perfusion, hence protecting against the cardiometabolic complications of obesity.
聚焦教學對華語「知道類」近義詞學習之效應
Authors: 吳 品嬅 , 陳 純音 , 賴 惠玲
Published: September 2024

提要

本文旨在針對「知道類」心理思維動詞「知道」、「懂」、「了解」、「明白」語義, 設計教學, 探討其成效。首先依吳品嬅等 (2023) 之分析結果, 設計四天教學計畫, 繪製語義網及句型搭配圖作為教學輔助工具, 並將參與該研究的32名中級程度外籍學生分成兩組, 一組為實驗組進行聚焦教學, 另一組則為對照組採用傳統式教學。研究發現, 經過教學後, 兩組後測之成績皆顯著高於前測, 顯示教學成效明顯。在半年後的追蹤測部分, 實驗組之表現持平, 與後測相較未達到顯著。對照組之成績比後測呈現明顯退步, 證明採用聚焦教學之持續效應遠高於傳統式教學。此外, 兩次測驗中的成績依序為「知道」、「懂」、「了解」、「明白」, 顯示「知道」最易掌握, 「明白」則否。本研究同時根據研究結果, 提出相關教學建議, 以供第一線教學者參考。
Targeted MRM-analysis of plasma proteins in frozen whole blood samples from patients with COVID-19: a retrospective study
Authors: Bugrova Anna E. , Strelnikova Polina A. , Kononikhin Alexey S. , Zakharova Natalia V. , Diyachkova Elizaveta O. , Brzhozovskiy Alexander G. , Indeykina Maria I. , Kurochkin Ilya N. , Averyanov Alexander V. , Nikolaev Evgeny N.
Published: September 2024

Objectives

The COVID-19 pandemic has exposed a number of key challenges that need to be urgently addressed. Mass spectrometric studies of blood plasma proteomics provide a deep understanding of the relationship between the severe course of infection and activation of specific pathophysiological pathways. Analysis of plasma proteins in whole blood may also be relevant for the pandemic as it requires minimal sample preparation.

Methods

The frozen whole blood samples were used to analyze 203 plasma proteins using multiple reaction monitoring (MRM) mass spectrometry and stable isotope-labeled peptide standards (SIS). A total of 131 samples (FRCC, Russia) from patients with mild (n=41), moderate (n=39) and severe (n=19) COVID-19 infection and healthy controls (n=32) were analyzed.

Results

Levels of 94 proteins were quantified and compared. Significant differences between all of the groups were revealed for 44 proteins. Changes in the levels of 61 reproducible COVID-19 markers (SERPINA3, SERPING1, ORM1, HRG, LBP, APOA1, AHSG, AFM, ITIH2, etc.) were consistent with studies performed with serum/plasma samples. The best-performing classifier built with 10 proteins achieved the best combination of ROC-AUC (0.97–0.98) and accuracy (0.90–0.93) metrics and distinguished patients from controls, as well as patients by severity.

Conclusions

Here, for the first time, frozen whole blood samples were used for proteomic analysis and assessment of the status of patients with COVID-19. The results obtained with frozen whole blood samples are consistent with those from plasma and serum.
Survey on machine vision-based intelligent water quality monitoring techniques in water treatment plant: Fish activity behavior recognition-based schemes and applications
Authors: Xu Pengfei , Liu Xianyi , Liu Jinping , Cai Meiling , Zhou Ying , Hu Shanshan , Chen Minlian
Published: September 2024

Water is a vital resource essential to the survival and development of all creatures. With the rapid growth of industry and agriculture, people face a severe threat of ecological destruction and environmental pollution while living earthly lives. Water pollution, in particular, harms people’s health the most. As a result, water supply security has become a top priority. As a critical point in water supply safety, monitoring water quality effectively and forecasting sudden water contamination on time has become a research hotspot worldwide. With the rapid development and wide applications of artificial intelligence and computer vision technologies, biological activity identification-based intelligent water quality monitoring methods have drawn widespread attention. They were taking fish activities as the water-quality indicator has gained extensive attention by introducing advanced computer vision and artificial intelligence technologies with low cost and ease of carrying. This article comprehensively reviews recent progress in the research and applications of machine vision-based intelligent water quality monitoring and early warning techniques based on fish activity behavior recognition. In detail, it addresses water quality-oriented fish detection and tracking, activity recognition, and abnormal behavior recognition-based intelligent water quality monitoring. It analyzes and compares the performance and their favorite application conditions. Finally, it summarizes and discusses the difficulties and hotspots of water quality monitoring based on the fish’s abnormal behavior recognition and their future development trends.
Convergence of Peaceman-Rachford splitting method with Bregman distance for three-block nonconvex nonseparable optimization
Authors: Zhao Ying , Lan Heng-you , Xu Hai-yang
Published: September 2024

It is of strong theoretical significance and application prospects to explore three-block nonconvex optimization with nonseparable structure, which are often modeled for many problems in machine learning, statistics, and image and signal processing. In this article, by combining the Bregman distance and Peaceman-Rachford splitting method, we propose a novel three-block Bregman Peaceman-Rachford splitting method (3-BPRSM). Under a general assumption, global convergence is presented via optimality conditions. Furthermore, we prove strong convergence when the augmented Lagrange function satisfies Kurdyka-Łojasiewicz property. In addition, if the association function possessing the Kurdyka-Łojasiewicz property exhibits a distinctive structure, then linear and sublinear convergence rate of 3-BPRSM can be guaranteed. Finally, a preliminary numerical experiment demonstrates the effectiveness.