bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of urbanization in facilitating the introduction and establishment of non-native animal species: a comprehensive review
Authors: Carlon Eugenio , Dominoni Davide M
Published: August 2024

While urbanization is often associated to a loss of biodiversity, non-native animal species are strikingly successful in urban landscapes. As biological invasions are recognized to have detrimental environmental, social and economic impacts, extensive understanding of the interactions between invasive species and the abiotic and biotic environment is necessary for effective prevention and management strategies. However, the mechanisms underlying the success of invasive animals in urban environments are still poorly understood. We provide a first conceptual review of the role of urbanization in the introduction, establishment, and potential spread of non-native animal species. We summarize and discuss the mechanisms enhancing biological invasive potential of non-native animals in urban environments, by both isolating and interlinking the abiotic and biotic drivers involved. Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA 2020) process, this systematic review covers a total of 124 studies comprehensive of all taxonomic groups, albeit with an evident publication bias for avian and terrestrial invertebrate species (22.1% and 19.8% of literature respectively). High-income regions also represent a larger bulk of the literature (Europe: 26.7%, North America: 23.7%). The most common reported factors facilitating species invasions in urban areas are reduced biotic resistance, and the competitive and urban-compatible ecological and/or behavioural traits of non-native animals allowing urban exploitation and aiding invasion. Finally, we identify important knowledge gaps, such as the scarcity of studies investigating socio-economic spatial patterns in the presence and abundance of invasive species, as well as the adaptive evolution of non-native animal species in urban areas.
Unfinished forgiveness: dynamics of Igbo cosmology and Christian theology in Chigozie Obioma’s An Orchestra of Minorities
Authors: Livingstone Justin D
Published: August 2024

Chigozie Obioma’s An Orchestra of Minorities, a novel embedded in the Igbo traditions of Odinani, is acclaimed as a literary exercise in alternative cosmology. Yet the book is also seriously engaged with Christian theology. This essay argues that the novel’s account of wrongdoing, repentance, and remission, offers a careful analysis of the dynamics of Christian forgiveness, sharpened by its Igbo cosmological perspective. The tensions that it dramatizes between an honor-shame code and the demands of forgiveness, simultaneously critique the logic of retribution and problematize romantic and therapeutic models of forgiving. By dwelling on the complications of resolving offences, and opening taxing questions around political injustices, An Orchestra of Minorities pushes towards a refined moral grammar in which forgiveness is not impossible but routinely unfinished.
Candida auris: Understanding the dynamics of C. auris infection versus colonization
Authors: Park Sungsoo , Kim Heesuk , Hong Duckjin , Oh Hyeyoung
Published: August 2024

Candida auris is a pathogen of growing public health concern worldwide. However, risk factors contributing to C. auris infection in patients colonized with C. auris remain unclear. Understanding these risk factors is crucial to prevent colonization-to-infection transition and devise effective preventive strategies. This study aimed to investigate risk factors associated with C. auris infection compared to colonization. The study included 97 patients who acquired laboratory-confirmed C. auris in either matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry or VITEK 2 system from October 2019 to June 2023. Baseline demographics and known risk factors associated with C. auris infection were collected from electronic medical records. The infection group had C. auris from a sterile site or non-sterile site with evidence of infection. The colonization group was followed up for a median of 30 days for any signs of infection. Associations between relevant variables and C. auris infection were assessed using multivariable logistic regression. The infection group (n = 31) was more likely to be bedbound, with longer hospital stays and more arterial catheters. Chronic kidney disease (odds ratio [OR] 45.070), carriage of multidrug-resistant organisms (OR 64.612), and vasopressor use for > 20 days (OR 68.994) were associated with C. auris infection, after adjusting for sex, age, and prior colonization with C. auris. Chronic kidney disease, carriage of multidrug-resistant organisms, and prolonged vasopressor use emerged as significant risk factors for C. auris infection compared to colonization. They could be used to predict C. auris infection early in patients colonized with C. auris.
Mitochondrial DNA Genomes Reveal Relaxed Purifying Selection During Human Population Expansion after the Last Glacial Maximum
Authors: Zheng Hong-Xiang , Yan Shi , Zhang Menghan , Gu Zhenglong , Wang Jiucun , Jin Li
Published: August 2024

Modern humans have experienced explosive population growth in the past thousand years. We hypothesized that recent human populations have inhabited environments with relaxation of selective constraints, possibly due to the more abundant food supply after the Last Glacial Maximum. The ratio of nonsynonymous to synonymous mutations (N/S ratio) is a useful and common statistic for measuring selective constraints. In this study, we reconstructed a high-resolution phylogenetic tree using a total of 26,419 East Eurasian mitochondrial DNA genomes, which were further classified into expansion and nonexpansion groups on the basis of the frequencies of their founder lineages. We observed a much higher N/S ratio in the expansion group, especially for nonsynonymous mutations with moderately deleterious effects, indicating a weaker effect of purifying selection in the expanded clades. However, this observation on N/S ratio was unlikely in computer simulations where all individuals were under the same selective constraints. Thus, we argue that the expanded populations were subjected to weaker selective constraints than the nonexpanded populations were. The mildly deleterious mutations were retained during population expansion, which could have a profound impact on present-day disease patterns.
Placement of tunnelled haemodialysis catheters—interventional standard
Authors: Schröppel Bernd , Bettac Lucas , Schulte-Kemna Lena , Kächele Martin
Published: August 2024

While the native arteriovenous fistula remains the first choice in vascular access for most haemodialysis patients, tunnelled haemodialysis catheters (tHDCs) continue to be an option in selected patients. Since timely access to vascular surgery—due to delayed referral or resource limitations—is not always possible, nephrologists have to become more actively involved in planning, creation and monitoring of vascular access. Moreover, this approach could also strengthen patient-centred care in nephrology. This article reviews the current standard in tHDC creation, patient selection and strategies to mitigate the risk of infectious complications and catheter thrombosis. Presentation of novel developments in catheter placement with ultrasound-guided or electrocardiogram-guided positioning, their benefits and possible disadvantages emphasizes the complexity of vascular access planning. We offer an approach for the choice of insertion method, depending on selected side and existing resources and focus on the necessity and required resources of ‘interventional nephrology’ training programs.
Ultra-sensitivity in reconstructed exceptional systems
Authors: Chen Tian , Zou Deyuan , Zhou Zilong , Wang Ruiguo , Feng Yue , Sun Houjun , Zhang Xiangdong
Published: August 2024

Sensors are of fundamental importance and widely used in modern society, such as in industry and environmental monitoring, biomedical sample ingredient analysis and wireless networks. Although numerous sensors have been developed, there is a continuous demand for sensors with increased sensitivity, to detect signals that were previously undetectable. Recently, non-Hermitian degeneracies, also known as exceptional points (EPs), have attracted attention as a way of improving the responsiveness of sensors. In contrast to previous investigations, here we present a new approach to achieving ultra-sensitivity by reconstructing exceptional systems. In the reconstruction process, some eigenstates near the previous EPs are utilized, and non-reciprocal long-range couplings are introduced. The sensitivities of our reconstructed systems have improved by several orders of magnitude compared to those based on EPs. Furthermore, we design and fabricate corresponding integrated circuit sensors to demonstrate the scheme. Our work paves the way for the development of highly sensitive sensors, which have a wide range of applications in various fields.
Significant chlorine emissions from biomass burning affect the long-term atmospheric chemistry in Asia
Authors: Chang Di , Li Qinyi , Wang Zhe , Dai Jianing , Fu Xiao , Guo Jia , Zhu Lei , Pu Dongchuan , Cuevas Carlos A , Fernandez Rafael P , Wang Weigang , Ge Maofa , Fung Jimmy C H , Lau Alexis K H , Granier Claire , Brasseur Guy , Pozzer Andrea , Saiz-Lopez Alfonso , Song Yu , Wang Tao
Published: August 2024

Biomass burning (BB) is a major source of trace gases and particles in the atmosphere, influencing air quality, radiative balance, and climate. Previous studies have mainly focused on the BB emissions of carbon and nitrogen species with less attention on chlorine. Reactive chlorine chemistry has significant effects on atmospheric chemistry and air quality. However, quantitative information on chlorine emissions from BB, particularly the long-term trend and associated atmospheric impacts, is limited both on regional and global scales. Here, we report a long-term (2001–2018) high-resolution BB emission inventory for the major chlorine-containing compounds (HCl, chloride, and CH3Cl) in Asia based on satellite observations. We estimate an average of 730 Gg yr−1 chlorine emitted from BB activity in Asia, with China contributing the largest share at 24.2% (177 Gg yr−1), followed by Myanmar at 18.7% and India at 18.3%. Distinct seasonal patterns and significant spatial and interannual variability are observed, mainly driven by human-mediated changes in agricultural activity. By incorporating the newly developed chlorine emission inventory into a global chemistry-climate model (CAM-Chem), we find that the BB-chlorine emissions lead to elevated levels of HCl and CH3Cl (monthly average up to 2062 and 1421 parts per trillion by volume (pptv), respectively), subsequently resulting in noticeable changes in oxidants (up to 3.1% in O3 and 17% in OH radicals). The results demonstrate that BB is not only a significant source of air pollutants but also of oxidants, suggesting a larger role of BB emissions in the atmospheric chemistry and oxidation process than previously appreciated. In light of the projected increase in BB activity toward the end of the century and the extensive control of anthropogenic emissions worldwide, the contribution of BB emissions may become fundamental to air quality composition in the future.
Preclinical Evidence for the Protective Capacity of Antibodies Induced by Lyme Vaccine Candidate VLA15 in People
Authors: Lundberg Urban , Hochreiter Romana , Timofoyeva Yekaterina , Kanevsky Isis , Meinke Andreas , Anderson Annaliesa S , Simon Raphael
Published: August 2024

Background

Vaccine candidate VLA15 is designed to protect against the dominant Borrelia genospecies-causing Lyme disease in North America and Europe. Active immunization with VLA15 has protected in the mouse model of tick challenge. VLA15 is currently under evaluation in clinical studies for the prevention of Lyme borreliosis.

Methods

Mice were passively administered sera from clinical trial participants vaccinated with VLA15, or normal human serum from unvaccinated individuals as control. Posttransfer serum anti-outer surface protein A (OspA) immunoglobulin G titers were assessed by enzyme-linked immunosorbent assay. Following passive transfer, mice were challenged with Ixodes ticks colonized with Borrelia burgdorferi (OspA serotype 1) or Borrelia afzelii (OspA serotype 2) and infection was determined by serology for VlsE C6 or by polymerase chain reaction and culture to assess the presence of Borrelia bacteria.

Results

Passive transfer of immune sera prevented transmission of Borrelia from the tick vector and protected mice against challenge. Posttransfer protective threshold immunoglobulin G antibody titers were observed in this animal model of 131 U/mL for B burgdorferi (OspA serotype 1) and 352 U/mL for B afzelii (serotype 2).

Conclusions

Passive transfer of sera from trial participants immunized with VLA15 protected mice from borreliosis in a tick challenge model. This indicates that VLA15 induces functional immune responses in people that can be linked to efficacy in a stringent preclinical model.
Where do field-specific notions of research quality come from?
Authors: Laudel Grit
Published: August 2024

Researchers’ notions of research quality depend on their field of research. Previous studies have shown that field-specific assessment criteria exist but could explain neither why these specific criteria and not others exist, nor how criteria are used in specific assessment situations. To give initial answers to these questions, formal assessment situations (reviews of publications) and informal assessment situations (seminar and conference discussions) in two specialties (plant biology and medieval history) were analysed through observations and qualitative content analysis. The empirical findings reveal a large variety of quality criteria used by researchers, which cannot be subsumed under conventional notions of originality, reliability, or validity. The identified field-specific quality criteria can be explained by differences between the two fields’ research practices and between the epistemic properties of the two fields.
Transfer versus co-production: Knowledge as ‘MEANS’ to sustainability as an ‘END’
Authors: Chams Nour , Guesmi Bouali , Molins i Folch Mireia , Cubel Rosa , Gil Roig Jose Maria
Published: August 2024

This study examines the relationship between sustainability performance and knowledge, as well as between innovation transfer and co-production. It moves away from evaluating processes to exploring impact by investigating how explicit and tacit knowledge archetypes are associated with sustainability performance in the agri-food sector. Applying the knowledge-based theory and the Shannon index, we rely on a database from 2013 to 2020 of two case studies selected from a Spanish research institution. At the institutional level, the results postulate that knowledge and innovation transfer tends to have a higher diversity index, mainly driven by explicit knowledge archetype. Tacit type of knowledge in both transfer and co-production mechanisms predominately relies on engagement parameters. At the case study level, as an educational toolkit, the first case study prioritizes engagement that is, transferring and transmitting knowledge to a higher number of participants—tacit knowledge transfer. As an innovative technique, the second case study prioritizes diversity that is, transferring and transmitting knowledge through various channels—explicit knowledge transfer. Regarding sustainability performance, the findings demonstrate that both explicit and tacit knowledge are associated with health and capacity building pillars in the first case study through the transfer mechanism. However, in the second one, tacit knowledge is mainly associated with economic and socioterritorial pillars through transfer and co-production mechanisms. This study sheds light on the micro level of knowledge, proposing an approach for researchers and practitioners to categorize knowledge in different proxies and evaluate their performance.
Penalizing Nonconformity: Gender Nonconformity at the Intersection of Gender and Sexual Identity in the Labor Market
Authors: Hsu Jaime
Published: August 2024

Previous research has identified wage penalties for women and sexual minority workers. However, these analyses did not consider how gender nonconformity may influence our current understanding of these penalties. Therefore, this study aims to explore the wage penalty associated with gender nonconformity at the intersection of gender and sexual identity. It theorizes how gender nonconformity contributes to labor market inequality by distinguishing the impacts of gender nonconformity, gender identity, and sexual identity on wages. Using a novel measurement in the fifth wave of the National Longitudinal Study of Adolescent to Adult Health, the results indicate that heterosexual men and women experience wage penalties for being gender nonconforming compared to their conforming counterparts. Interestingly, gender nonconformity is not linked to wage penalties for gay, lesbian, and bisexual workers. These wage penalties persist even after adjusting for marital and parental statuses among nonconforming heterosexual men and women. Furthermore, nonconforming straight men earn significantly less than both conforming and nonconforming gay/bisexual men. These findings offer insights for future research to explore the labor market consequences of gender nonconformity for straight individuals, as well as gender and sexual minority workers.
Therapeutic hypothermia for neonates with hypoxic-ischaemic encephalopathy in low- and lower-middle-income countries: a systematic review and meta-analysis
Authors: Prakash Raj , Verónica Reyes-García Diana , Somanath Hansoge Sanjana , Rosenkrantz Ted S
Published: August 2024

Hypoxic-ischaemic encephalopathy (HIE) is a major cause of mortality and neurodevelopmental disability, especially in low-income countries. While therapeutic hypothermia has been shown to reduce morbidity and mortality in infants with HIE, some clinical trials in low-income countries have reported an increase in the risk of mortality. We conducted a systematic review and meta-analysis of all randomized and quasi-randomized controlled trials conducted in low-income and lower-middle-income countries that compared cooling therapy with standard care for HIE. Our primary outcome was composite of neonatal mortality and neurodevelopmental disability at 6 months or beyond. The review was registered with PROSPERO (CRD42022352728). Our review included 11 randomized controlled trials with 1324 infants with HIE. The composite of death or disability at 6 months or beyond was lower in therapeutic hypothermia group (RR 0.78, 95% CI 0.66–0.92, I2 = 85%). Neonatal mortality rate did not differ significantly between cooling therapy and standard care (RR 0.92, 95% CI 0.76–1.13, I2 = 61%). Additionally, the cooled group exhibited significantly lower rates of neurodevelopmental disability at or beyond 6 months (RR 0.34, 95%CI 0.22–0.52, I2 = 0%). Our analysis found that neonatal mortality rate did not differ between cooled and noncooled infants in low- and lower-middle-income countries. Cooling may have a beneficial effect on neurodevelopmental disability and the composite of death or disability at 6 months or beyond.
Is Social Support Associated With Clinical Outcomes in Adults With Nonspecific Chronic Low Back Pain? A Systematic Review
Authors: Bisconti Mattia , Esposto Massimo , Tamborrino Andrea , Brindisino Fabrizio , Giovannico Giuseppe , Salvioli Stefano
Published: August 2024

Objectives:

Nonspecific chronic low back pain (NSCLBP) is associated with psychological and social factors such as social support. However, little research has focused on the latter. This article aimed to review the literature on the association between social support and clinical outcomes of patients with NSCLBP, particularly regarding differences in sex, gender, and types of social support.

Methods:

MEDLINE, EMBASE, Web of Science, PsycINFO, and CENTRAL were searched until April 19, 2024, without restrictions of time or language. Eligible articles were observational studies reporting measures of association between social support and clinical outcomes among adults with NSCLBP. Risk of bias was assessed using the QUIPS tool, and findings were analyzed qualitatively. This systematic review was registered on PROSPERO (CRD42022363210).

Results:

Of the 3528 identified studies, 11 were included in the review (1290 patients), showing a moderate to high risk of bias. Of the 5 studies showing a significant finding for pain, 4 reported a negative correlation (r=−0.18, −0.32, −0.35, −0.36) and 1 did not report any association index. Of the 6 studies showing a significant finding for disability, 2 reported a negative correlation (r=−0.29, −0.42), 2 reported a positive association (r=0.322; β=0.29), and 2 did not report any association index. No data was available for the investigated subgroups or secondary clinical outcomes.

Discussion:

Small associations were found between social support and clinical outcomes of individuals with NSCLBP. Further research is needed to establish its clinical relevance according to types of social support, sex, and gender.
A Study to Determine Consensus for Nursing Documentation Reduction in Times of Crisis
Authors: Hoelscher Stephanie H. , McBride Susan , Bumpus Serena , Gilder Richard E. , Elkind Elizabeth
Published: August 2024

Nurses faced numerous challenges during the pandemic, particularly with the increased burden of electronic documentation. Surges in patient volume and visits led to rapid changes in nursing documentation, prompting diverse responses from regulatory and healthcare organizations. Nurses expressed safety concerns and struggled with changes, calling for national standards and regulatory support. Policy relaxations, such as the 1135 Waiver, sparked debate on the future of nursing care plan documentation. Using mixed-methods exploratory design, the study identified modifications of nursing documentation during crises, commonalities in documentation burden reduction for applicability beyond pandemics, and consensus on the definition of “surge.” Documentation patterns were assessed from February to November 2022, involving 175 North American nurse leaders and informaticists. Data analysis included descriptive statistics, thematic analysis, and Pearson correlation coefficient. Significant differences were found between rural and urban settings (P = .02), with urban areas showing higher odds of changes to care plans (odds ratio, 4.889; 95% confidence interval, 1.27-18.78). Key findings highlighted the persistence of postcrisis documentation changes and varied definitions of surge criteria based on organizational leadership, policy, and mandates. The study yielded insights for modifying documentation, offering policy recommendations, and emphasizing ongoing collaboration and evidence-based approaches for future nursing practices.
The causality of atrial fibrillation on frailty index: A Mendelian randomization study
Authors: Chen Shoulei , Luo Cheng , Zheng Baoshi
Published: August 2024

Prior epidemiological research has indicated a possible association between atrial fibrillation (AF) and frailty status. Our study used Mendelian randomization to estimate its causality. The genome-wide association studies for AF were utilized as the exposure for individuals included in the UK Biobank (n = 463,010) and publicly available summary statistics data sets of genome-wide association studies meta-analyses for frailty index in individuals of European descent (n = 175,226) was used as the outcome. The inverse variance weighting method was utilized to evaluate causality. To further confirm the reliability of the results, sensitivity analyses were conducted. The inverse variance weighting analysis indicated that the presence of AF was found to be statistically linked to an increased risk of frailty (odds ratio = 3.017, CI: 1.106–8.232, P = .031). MR-Egger intercept test indicated no pleiotropy (Egger intercept = .002, P = .808). The leave-one-out method indicated that the individual SNPs did not have an impact on the robustness of the findings. The research implies a causal relationship between AF and frailty. Early detection and timely intervention of AF can control the occurrence of frailty.
Expression of p16INK4a, FLOT2, and EGFR in oropharyngeal carcinoma, prognostic significance and correlation with clinicopathological characteristics
Authors: Đokanović Dejan , Gajanin Radoslav , Gojković Zdenka , Klokić Semir , Sladojević Igor , Gajanin Vesna , Reljić Dragana , Jović-Đokanović Olja , Amidžić Ljiljana , Marošević Goran
Published: August 2024

Various factors can affect the survival of patients with oropharyngeal cancer. We assessed the expression of protein p16INK4a, Flotillin2, epidermal growth factor receptor, and other clinicopathological features and their prognostic value for this type of cancer. We gathered patient data on demographics, clinicopathological characteristics, treatment patterns, and outcomes. Histologically and by immunochemistry staining we determined expression of prognostic factors and molecular biomarkers. The primary endpoints were overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS). Survival was assessed using the Kaplan–Meier method and Cox regression model analyses of potential prognostic parameters. After a median follow-up of 78 months, the median OS was 41 months, with an event recorded in 77.8% of patients. Median DFS was 22 months, 37 patients (51.4%) had disease relapse. The DSS survival rate was 58.3% with a median survival of 68 months. In regards to molecular biomarkers previously mentioned, there was no statistical significance for survival categories. After conducting a multivariate analysis of significant variables, we found that only recurrence, vascular invasion, and surgical intervention remained as factors with independent effects on both OS and DFS. Recurrence and the N stage were identified as independent prognostic factors for DSS. Our analysis underscores the complexity of factors that collectively influence survival following the diagnosis of OPSCC. Several factors were found to be statistically significant. These factors included the type of surgical procedure, disease relapse, vascular invasion, lymphatic invasion, perineural invasion, advanced T stage of the disease, N stage of the disease, and smoking status. The significance of these factors may vary across different types of survival. This analysis did not find any significant impact on survival from the growth factors tested, namely epidermal growth factor receptor, Flotillin2, and p16INK4a, in the applied regression models.
Progress of heparanase in septic cardiomyopathy: A review
Authors: Chen Di , Wang Lin-Jun , Li Hong-Lei , Feng Fei , Li Jian-Chun , Liu Liping
Published: August 2024

Septic cardiomyopathy (SCM) is a severe complication caused by sepsis, resulting in a high mortality rate. The current understanding of the pathogenic mechanism of SCM primarily involves endocardial injury, microcirculation disturbance, mitochondrial dysfunction and fibrosis. Heparanase (HPA), an endo-β-D-glucuronidase, has been implicated in inflammation, immune response, coagulation promotion, microcirculation disturbance, mitochondrial dysfunction and fibrosis. Therefore, it was hypothesized that HPA may play an important role in the pathogenesis of SCM. The present study provides a summary of various pathophysiological changes and mechanisms behind the involvement of HPA in SCM. It also presents a novel perspective on the pathogenic mechanism, diagnosis and treatment of SCM.
With advancement in health technology comes great responsibility – Ethical and safety considerations for using digital health technology: A narrative review
Authors: Grosman-Rimon Liza , Wegier Pete
Published: August 2024

The accelerated adoption of digital health technologies in the last decades has raised important ethical and safety concerns. Despite the potency and usefulness of digital health technologies, addressing safety, and ethical considerations needs to take greater prominence. This review paper focuses on ethical and safety facets, including health technology-related risks, users’ safety and well-being risks, security and privacy concerns, and risks to transparency and diminished accountability associated with the utilization of digital health technologies. In order to maximize the potential of health technology benefits, awareness of safety risks, and ethical concerns should be increased, and the use of appropriate strategies and measures should be considered.
Overlapping syndrome of anti-MOG antibody-associated disease and anti-mGluR5 encephalitis manifested as optic neuritis: A case report
Authors: He Jianhang , Niu Xiaoyan , Chen Xiaoyan , Ma Boya , Ren Yazhou , Qi Weimin , Zhan Xiuping , Meng Yue , Li Jianxia , Li Haining
Published: August 2024

Rationale:

Anti-Myelin oligodendrocyte glycoprotein (MOG) and anti-metabotropic glutamate receptor 5 (mGluR5) double antibody positive encephalitis characterized by optic neuritis is extremely rare. We present a case of overlapping syndrome of MOG-IgG-associated disease and anti-mGluR5 encephalitis manifested as optic neuritis.

Patient concerns:

A 60-year-old Chinses woman presented to the hospital with progressive vision loss and headache for 1 week. The cerebrospinal fluid examination was within the normal range. Visual evoked potentials study disclosed prolonged latency of P100 bilaterally. Fundus examination revealed indistinct boundaries of both optic discs. Her brain magnetic resonance imaging showed patchy hyperintensity in the posterior horn of the left ventricle and the left optic nerve. Her serum was positive for anti-MOG and anti-mGluR5 antibodies.

Diagnosis:

The patient was diagnosed with overlapping syndrome of anti-MOG antibody-associated disease and anti-mGluR5 encephalitis mainly based on the clinical symptoms and further test of the antibody in serum.

Interventions and outcomes:

She was subsequently subjected to empirical treatment with intravenous methylprednisolone. After discharge, she was given a tapering dose of oral prednisone, alongside mycophenolate mofetil. On outpatient follow-up, her symptoms showed no relapse after 1 month, and her condition remained stable.

Lessons:

Early recognition of autoimmune encephalitis is crucial. The detection of cerebrospinal fluid and serum of autoimmune encephalitis and demyelinating diseases of the CNS, including MOG-IgG and mGluR5-IgG, should be strengthened in order to make a precise diagnosis and develop a comprehensive treatment plan in a timely manner.
Exploration of biomarkers for nursing physical examination early screening of multiple tumors
Authors: Li Xuepu , Li Ruipu
Published: August 2024

Nursing and physical examination early screening of multiple tumors is helpful to find tumors early, so as to improve the cure rate. Studying its molecular mechanisms is urgent. By logging into gene expression omnibus database, we found laryngeal cancer dataset GSE127165, bladder cancer dataset GSE65635, oral cancer dataset GSE146483, obtain differentially expressed genes, subsequently, weighted gene co-expression network analysis, protein–protein interaction networks, functional enrichment analysis, immune infiltration analysis, survival analysis, comparative toxicogenomics database analysis were conducted. Draw a heatmap of gene expression. Use targetScan to search for miRNA information about core DEG. Got 53 differentially expressed genes. In GOKEGG analysis, they were clustered in cell cycle processes, spindle poles, and protein serine/threonine/tyrosine kinase activity cell cycle, transcriptional dysregulation in cancer, RIG-I-like receptor signaling pathway, P53 signaling pathway. Protein–protein interaction analysis screened out 5 genes (NEK2, BUB1, HMMR, TTK, CCNB2). Cyclin B2 (CCNB2) and budding uninhibited by benzimidazole 1 (BUB1) were highly expressed in laryngeal cancer, bladder cancer, oral cancer. Comparative toxicogenomics database analysis found that core genes (CCNB2, BUB1) are associated with tumors, necrosis, and inflammation. Related miRNA of CCNB2 gene is hsa-miR-670-3p; related miRNAs of BUB1 gene are hsa-miR-5688, hsa-miR-495-3p. CCNB2 and BUB1 exhibit high expression in laryngeal cancer, bladder cancer, and oral cancer, suggesting their potential as molecular targets for precision therapy in these cancers.
Systemic contact dermatitis in a family: Case report
Authors: Sun Guang-mei , Li Ting-ting , Zhang Jin-mei , Liu Hai-yan , Xu Yan-li , Zhang Bao-xiang
Published: August 2024

Background:

Systemic contact dermatitis (SCD) is an allergic inflammatory skin disease. We report that 3 family members developed SCD after exposing to laundry detergent containing benzalkonium chloride, which is rare. SCD caused by benzalkonium chloride has been reported. However, Similar symptoms in the whole family caused by it have not been reported yet. In our case, a 36-year-old man was diagnosed as SCD, and his symptoms had not controlled after 7 days treatment, until he stopped dressing the clothes washed by the laundry detergent containing benzalkonium chloride. It was interesting that both his wife and the daughter developed SCD successively, and they have not exposed to any haptens besides the benzalkonium chloride in the laundry detergent.

Methods:

Dermoscopic examination showed bright-red background, focal branching vessels and white scales. HE staining from the lesion revealed hyperkeratosis and parakeratosis, focal subcorneal microabscess, ocal hyperkeratosis, koilocyte in the epidermis, and erythrocyte extravasation, fibroplasia, hyaline degeneration and scattered aggregates of lymphocytes in the dermis. Then path test was performed 1 month after recovery with benzalkonium chloride 0.05% and 0.1% in petrolatum.

Results:

Stop the laundry detergent containing benzalkonium chloride. The symptoms had controlled after they stopped the laundry detergent containing benzalkonium chloride.

Conclusion:

The case highlights that benzalkonium chloride with very low concentration and repeated exposure may be an active agent of SCD. It is of the utmost importance to pay close attention to patients presenting with similar symptoms within the family. A thorough examination of the medical history is essential to determine the underlying cause.
Case series multilocular cystic hemangioma of the liver: Three cases and literature review
Authors: Liang Chunmiao , Yu RiSheng , Wang Liuhong , Chen Ying
Published: August 2024

Rationale:

Multilocular cystic hemangioma is a rare benign tumor classified as an atypical hemangioma. Currently, there are limited imaging reports available, and the imaging characteristics can be challenging to distinguish from other malignant multilocular cystic liver diseases such as cystadenocarcinoma, necessitating confirmation through pathological diagnosis. Here, we discuss the imaging features of 3 cases of multilocular cystic hemangiomas.

Patient concerns and Diagnoses:

Case 1 was a 24-year-old young female, and Case 2 involved a 60-year-old elderly male. Both patients were asymptomatic and physical examination revealed hepatic space-occupying lesions. Imaging findings revealed multilocular cystic lesions in the left liver with septa, calcification, a high diffusion-weighted magnetic resonance imaging (DWI) signal at the edge of the lesion, and progressive enhancement of the cyst wall and septa. Case 3 involved a 50-year-old male patient with epigastric distending pain for 1 month and sudden severe abdominal pain for 14 hours. Imaging results revealed a multilocular cystic lesion in the left liver with septa and tumor bleeding, a high DWI signal, and an enhanced cyst wall and septa. The pathological diagnosis confirmed a hepatic hemangioma.

Interventions:

All 3 patients underwent liver tumor resection.

Outcomes:

All 3 patients recovered successfully without any intraoperative or postoperative complications during the follow-up periods of 5 years, 6 months, and 5 months. There were no signs of recurrence.

Lessons:

Liver imaging revealed multilocular cystic lesions with features, such as compartmentalization, calcification, or bleeding. Multilocular cystic hemangiomas should be considered in imaging diagnosis. Enhancing our understanding of multilocular cystic hemangiomas can aid in improving the differential diagnosis of other malignant multilocular cystic liver diseases, ultimately reducing unnecessary liver resection.
Pancreatic head carcinoma derived from the dorsal pancreas is more likely to metastasize early than from the ventral pancreas through microvascular invasion
Authors: Gao Yuan , Shen Yuhang , Dong Jun , Zhou Yang , Zhu Chunfu , Yu Qiang , Qin Xihu
Published: August 2024

The development of the pancreatic head originates from the fusion of the ventral and dorsal pancreatic primordia during embryonic development. Theoretically, the origin of pancreatic head cancer also exists from the ventral pancreas and the dorsal pancreas. Among 49 patients with pancreatic head cancer, pancreatic head cancer was divided into pancreatic head cancer originating from the ventral (PHCv) or dorsal pancreas (PHCd) through imaging and pathological classification. The clinical data was collected and compared between the PHCv group and the PHCd group. The results showed that the patients from the PHCd group had worse long-term survival than those from the PHCv group (10 months vs 14.5 months). Similarly, the progression-free survival (PFS) results also indicate that patients from the PHCd group had a shorter time than those from the PHCv group (5 months vs 9.5 months). Further stratified analysis of potentially related factors showed that microvascular invasion is related to poor prognosis, and patients with pancreatic head cancer derived from the dorsal pancreas are more likely to develop microvascular invasion.
Polymorphisms in miR-17-92 cluster promoter region is associated with risk and prognosis of endometrial cancer
Authors: Jie Zhihui , Li Ping , Wu Huili , Zhou Yan , Wu Jianlei
Published: August 2024

Accumulating researches have reported that miR-17-92 cluster expression has strong association with tumorigenesis. In this study, we investigated the effects of 2 genetic polymorphisms in the promoter region of the miR-17-92 cluster and the risk and prognosis of endometrial cancer in northern Chinese women. Two polymorphisms (rs9588884 and rs982873) in the promoter of miR-17-92 cluster were genotyped by polymerase chain reaction and ligase detection reaction (PCR-LDR) in398 EC patients and 420 controls. The levels of miR-17-92 mRNA were investigated in 65EC tissues by real-time quantitative polymerase chain reaction (RT-qPCR). The impact of genetic features on the risk and clinical outcomes of EC was analyzed. The prognostic value of hsa-miR-17 and hsa-miR-20a in EC patients was assessed using the Kaplan–Meier plotter database. The results showed that a significant decrease in risk of EC with rs9588884 (GG vs CC: OR = 0.49, 95% CI = 0.32–0.78, P = .002; G vs C: OR = 0.75, 95% CI = 0.62–0.91, P = .005, respectively). Similarly, association was found between rs982873 and a decreased risk of EC (CC vs TT: OR = 0.53, 95% CI = 0.34–0.82, P = .004; C vs T: OR = 0.77, 95% CI = 0.63–0.94, P = .010, respectively). Moreover, survival analysis showed that the CG or GG genotype of rs9588884 may significantly increase overall survival (OS) compared with the CC genotype in the 5-year follow-up (HR = 0.49, 95% CI = 0.29–0.82 and HR = 0.36, 95% CI = 0.16–0.83, respectively). RT-qPCR results showed that the expression level of miR-17-92 mRNA in EC tissues with the rs9588884 GG genotype was significantly lower than those with the GC + CC genotype (P = .030). However, there was no significant difference in the prognosis and expression level of miR-17-92mRNA in tissues of EC patients with different genotypes of rs982873 (P = .343). In addition, analysis using Kaplan–Meier plotter database showed that high hsa-miR-20a expression was significantly correlated with poor OS in EC patients (HR = 1.63, 95% CI = 1.02–2.61, P = .039). The genetic polymorphisms rs9588884 and rs982873 in the promoter of miR-17-92 cluster decreased EC risk. Both rs9588884 and the expression level of hsa-miR-20a mRNA may be associated with its clinical outcome in EC patients.
Construction and validation of a predictive model of mortality of tuberculosis-destroyed lung patients requiring mechanical ventilation: A single-center retrospective cohort study
Authors: Cui Kunping , Mao Yi , Jiang Liangshuang , Zheng Yongli , Yang Lang , Yang Yixiang , Wu Guihui , Tang Shenjie
Published: August 2024

The mortality rate for intensive care unit tuberculosis-destroyed lung (TDL) patients requiring mechanical ventilation (MV) remains high. We conducted a retrospective analysis of adult TDL patients requiring MV who were admitted to the intensive care unit of a tertiary infectious disease hospital in Chengdu, Sichuan Province, China from January 2019 to March 2023. Univariate and multivariate COX regression analyses were conducted to determine independent patient prognostic risk factors that were used to construct a predictive model of patient mortality. A total of 331 patients were included, the median age was 63.0 (50.0–71.0) years, 262 (79.2%) were males and the mortality rate was 48.64% (161/331). Training and validation data sets were obtained from 245 and 86 patients, respectively. Analysis of the training data set revealed that body mass index <18.5 kg/m2, blood urea nitrogen ≥7.14 mmol/L and septic shock were independent risk factors for increased mortality of TDL patients requiring MV. These variables were then used to construct a risk-based model for predicting patient mortality. Area under curve, sensitivity, and specificity values obtained using the model for the training data set were 0.808, 79.17%, and 68.80%, respectively, and corresponding values obtained using the validation data set were 0.876, 95.12%, and 62.22%, respectively. Concurrent correction curve and decision curve analyses confirmed the high predictive ability of the model, indicating its potential to facilitate early identification and classification-based clinical management of high-risk TDL patients requiring MV.
Unilateral lifebuoy cataract: A case report
Authors: Koshiishi Yuka , Nagata Mayumi , Matsushima Hiroyuki , Ito Sakae , Suzuki Shigenari , Matsumoto Haruka , Okayasu Akihiko , Senoo Tadashi
Published: August 2024

Rationale:

Lifebuoy cataract is a rare congenital condition characterized by lens thinning. Due to its rarity, detailed treatment reports and standardized surgical approaches are limited. This study aims to enhance the current body of knowledge by presenting comprehensive case reports and describing surgical techniques for the treatment of lifebuoy cataracts.

Patient concerns:

A 14-year-old boy was diagnosed with a congenital cataract in his right eye at the age of 9, which was left untreated. The patient visited our hospital due to progressive visual impairment.

Diagnoses:

The visual acuity of the right eye was counting fingers at 30 cm. The uncorrected visual acuity of the left eye was 20/100, whereas the best corrected visual acuity was 20/20. The intraocular pressures were 18 mm Hg (left eye) and 20 mm Hg (right eye). Slit-lamp microscopy revealed central calcification of the lens capsule in the right eye and slightly opaque cortical tissue in the periphery, with no observable lens nucleus. Anterior segment optical coherence tomography (CASIA2, TOMEY, Nagoya, Japan) of the right eye showed fused anterior and posterior capsules and an absence of the lens nucleus, leading to a diagnosis of lifebuoy cataract.

Interventions:

Cataract surgery was performed on the right eye. Following a 2.4-mm sclerocorneal incision and trypan blue staining, continuous curvilinear capsulorrhexis was performed around the central opacity. The surrounding cortex was removed using irrigation and aspiration, while a viscoelastic agent was injected between the central calcified membrane and the posterior capsule. The membranous tissue was carefully peeled away and removed using forceps. Despite residual posterior capsular opacification, posterior capsulotomy was not performed due to concerns about vitreous prolapse. The intraocular lens was fixed within the capsule. Ten days post-surgery, the remaining posterior capsular opacification was treated with neodymium-doped yttrium aluminum garnet laser capsulotomy.

Outcomes:

The uncorrected visual acuity and best corrected visual acuity of the right eye improved to 20/100 and 20/50, respectively.

Lessons:

This case report demonstrates a successful surgical approach for a lifebuoy cataract, highlighting its unique morphology and the need for careful, specialized techniques. These findings aim to guide ophthalmologists in managing this rare condition, potentially improving patient care.
Acute insomnia as the initial manifestation of Wilson’ s disease: A Case Report
Authors: Cheng Xiaofang , Chen Quanhui , Ma Haoyuan , Ren Qiuxia , Jiao Shusheng
Published: August 2024

Background:

Wilson’s disease (WD) is a rare autosomal recessive disease that causes impaired copper circulation and excretion. The initial manifestations of WD vary clinically, which makes early diagnosis very difficult. Sleep disorders have been described as common symptoms of WD, but the initial manifestations are in rare cases.

Case report:

This study aims to present a patient with acute insomnia as the initial manifestation of WD. Cranial magnetic resonance imaging showed extensive lesions in the bilateral putamen and caudate nucleus, pressure area of corpus callosum, midbrain, and pons. Interestingly, rare but characteristic signs of WD, such as “face of the giant panda,” were shown in this case. WD diagnosis was further established by decreased ceruloplasmin level and ATP7B (adenosine-triphosphatase copper transporting beta polypeptide) gene mutations.

Conclusions:

We describe acute insomnia as the initial manifestation of WD in a 21-year-old male patient. Timely diagnosis allows for early copper-eliminating pharmacotherapy, which is of high prognostic importance, as the patient may be more responsive to treatment at this point.
Bilateral facial nerve palsy complicating Kawasaki disease: A case report and literature review
Authors: Ou Rong , Tan Zhongyou , Liu Ling
Published: August 2024

Rationale:

Kawasaki disease (KD) manifests as an acute, self-limited vasculitis disease that constitutes the primary cause of acquired heart disease in children under 5 years of age. Facial nerve palsy (FNP) is a rare complication associated with coronary artery lesions (CALs) in patients with KD. Patients with KD and FNP usually present atypically, leading to a delayed diagnosis and treatment of KD.

Patient concerns:

A 4-month-old boy with fever, left FNP and bilateral conjunctival injection with spontaneous resolution, was admitted to the hospital, received a short course of intravenous dexamethasone, and experienced rapid FNP recovery on the first admission. The patient experienced a resurgence of fever, bilateral conjunctival injection, and right FNP, which led to readmission. Physical examination revealed redness at the site of Bacillus Calmette-Guérin inoculation, reddening of lips, and desquamation of the distal extremities. Echocardiography revealed right-sided CALs.

Diagnoses:

The patient initially missed KD on the first admission, and was later diagnosed with complete KD with FNP on the second admission.

Interventions and outcomes:

After a short course of intravenous dexamethasone, the left FNP resolved quickly. However, right FNP recurred after corticosteroids withdrawal. Meanwhile, more typical symptoms were observed, and KD was diagnosed. Treatment ensued with intravenous immunoglobulin (IVIG), aspirin, and dexamethasone. The patient achieved rapid remission, without recurrence. Echocardiography continued to show normal findings during 1-year follow-up after discharge.

Lessons:

The clinical symptoms of FNP complicating KD in children are atypical and can easily lead to delayed diagnosis and treatment. FNP in patients with KD may serve as a risk factor for CALs, which are more challenging to resolve than the FNP itself. Adding corticosteroids to IVIG may be recommended to reduce IVIG resistance, decrease the risk of developing CALs, and alleviate CALs.