bluuebunny/crossref_metadata_2025 huggingface dataset:
Advances and Application of a Novel Oral Anticoagulant in Specific Populations: Dabigatran Etexilate
Authors: Xu Delai , Su Cujin , Pan Jie
Published: October 2018

Background:

Dabigatran etexilate (DE) was approved by the FDA in 2010 to reduce the risk of stroke and
systemic embolism in adults with Non-valvular Atrial Fibrillation (NVAF). Compared with warfarin, a traditional
anticoagulant drug, DE exhibits a shorter half-life, improved dose-effect relationship, fewer food and drug interactions,
and can be taken orally without monitoring the conventional coagulation index. DE can also prevent or reduce the
severity of adverse events, such as attenuated drug efficacy or bleeding. It is convenient for patients to take DE due to
low levels of individual variation. This review aims to application of Dabigatran etexilate in specific populations.

Methods:

Fifty-five papers were included in the review.

Results:

We review the pharmacological mechanisms, pharmacokinetics and drug interactions, as well as the application
of DE for different clinical populations, and provide clinical guidelines.

Conclusion:

When using DE, one should consider the risk of bleeding, age, renal function, drug interactions, and
other factors.
Formulation and Evaluation of Neuroactive Drug Loaded Chitosan Nanoparticle for Nose to Brain Delivery: In-vitro Characterization and In-vivo Behavior Study
Authors: Qureshi Mohsin , Aqil Mohd. , Imam Syed Sarim , Ahad Abdul , Sultana Yasmin
Published: October 2018

Background:

The present work was designed to explore the efficacy of neuroactive drug
(risperidone) loaded chitosan lipid nanoparticle (RIS-CH-LNPs) to enhance the bioactivity in schizophrenia
via the nasal route.

Methods: The three-factor and three-level formulation by design approach was used for optimization
and their effects were observed on (Y1) size in nm, (Y2) % drug loading, and (Y3) % drug release. The
optimized formulation RIS-CH-LNPopt was further evaluated for its surface morphology, ex-vivo permeation
study, in-vivo behavior study, and stability study. The developed RIS-CH-LNPs showed
nanometric size range with high drug loading and prolonged drug release.

Results:

The optimized formulation (RIS-CH-LNPopt) has shown the particle size (132.7 nm), drug
loading (7.6 %), drug release (80.7 %) and further ex-vivo permeation study showed 2.32 fold enhancement
over RIS-SUS(suspension). In-vivo behavior studies showed that RIS-CH-LNPopt is able to show
significant greater bioefficacy as compared to RIS-SUS [intranasal (i.n), intravenous (i.v)]. The pharmacokinetic
and brain/plasma ratio of developed chitosan nanoparticle was higher at all time-points as
compared to RIS-SUS either given by intranasal or intravenous route that proves the direct nose to brain
transport pathway of the drug via nasal administration. The developed chitosan nanoparticle increases
nose to brain drug delivery as compared to the dispersion of equivalent dose.

The findings of this study substantiate the existence of a direct nose-to-brain delivery route
for RIS-CH-LNPs.
QSAR Analysis of Multimodal Antidepressants Vortioxetine Analogs Using Physicochemical Descriptors and MLR Modeling
Authors: Rajathei David M. , Parthasarathy Subbiah , Selvaraj Samuel
Published: October 2018

Background:

Vortioxetine is a multimodal antidepressant drug with combined effects on SERT as an inhibitor, 5-HT1A as agonist and 5-HT3A as an antagonist. Series of vortioxetine analogs have been reported as multi antidepressant compounds and they block serotonin transport into the neuronal cells, activate the postsynaptic 5-HT1A receptors and eliminate the low activity of 5-HT3A receptors.

Objective:

To explore the important properties of vortioxetine analogs involved in antidepressant activity by developing 2D QSAR models.

Methods:

Selections of significant descriptors were performed by Least Absolute Shrinkage and Selection Operator (LASSO) method and, the Multiple Linear Regression (MLR) method and All Subsets and GA algorithm included in QSARINS software were used for generating QSAR models. Further, the virtual screening was performed based on bioactivity and structure similarity using the PubChem database.

Results:

The four descriptor model of complementary information content (CIC2), solubility (bcutp3), mass (bcutm8) and partial charge in van der Waals surface area (PEOEVSA7) of the molecules is obtained for SERT inhibition with the significant statistics of R2= 0.69, RMSEtr= 0.44, R2 ext= 0.62 and CCCext= 0.78. For 5-HT1A agonist, the two descriptor model of molecular shape (Kappm3) and van der Waals volume of the atoms (bcutv11) with R2= 0.78, RMSEtr= 0.33, R2 ext = 0.83, and CCCext= 0.87 is established. The three descriptor model of information content (IC3), solubility (bcutp9) and electronegativity (GATSe5) of the molecules with R2= 0.61, RMSEtr= 0.34, R2 ext= 0.69 and CCCext= 0.72 is obtained for 5-HT3A antagonist. The antidepressant activities of 16 virtual screened compounds were predicted using the developed models.

Conclusion:

The developed QSAR models may be useful to predict antidepressant activity for the newly synthesized vortioxetine analogs.
Energy accounting in AC substations in case of transit currents flowing through the contact network
Authors: Varentsov V. M. , Bur’Yanovatyy A. I. , Ivanov M. A.
Published: October 2018

The purpose of the work is to clarify the methodology for determining the electric power consumption of traction substations of AC electric power for the transit of external power supply. The conditions for the emergence of significant transit through traction networks of external power supply are revealed. Using the example of the Ushaped scheme for the replacement of power transmission lines, it is shown that the intersystem power fluxes along the electric power transmission lines of the external power supply exert the greatest influence on the transit currents along the traction networks. For analysis, the local and transit components of the power flow are identified and a typical section of the electrical network is considered, containing three electrical connections at voltages of 330, 110 and 27.5 kV. In this case, the most significant factor affecting transit through the traction network is the transverse component of voltage drop, since its compensation in this network is difficult. Methods for estimating the transit current of a traction network are given. An engineering technique for estimating the electric power consumption for transit by software is proposed. Authors show the necessity and possibility of using the KORTES package for estimating transit currents of the traction network caused by external power supply. The results of calculations for two sections of different railways based on the data of the Regional Dispatch Office are presented. The influence of regional and traction loads on the path of transit currents is considered. Obtained relationships and developed methodology allow estimating the electric power consumption of traction substations for the transit of the power of external power supply.
Modelling of vibration-damping properties of elastic-viscoplastic layers of the roadbed. Problem statement 2
Authors: Bel’Kov V. M.
Published: October 2018

The present article is a continuation of the article [1], where was considered a model of the vibration damping properties of the subgrade at the main area of the sole of a ballast prism of normalized thickness, a protective sand cushion and clay soils under conditions of harmonic vibrations on the basis of physical and chemical mechanics. It was noted that the Kelvin-Vogt model, currently used for modeling, is not applicable for layered systems that do not have, in principle, concentrated masses. For the occurrence of oscillations in the clay layer, it is necessary that under it there would be a medium reflecting the vertical longitudinal wave. Otherwise, the reverse half-wave will not form, and the compression wave will go deep into the ground and turn into heat in the end. Such problems can be solved only using the theory of wave processes. On the basis of the harmonic analysis of wave processes in layered systems for the ballast track, it is shown that the displacement amplitude at the sand-loam boundary decreases 26 times in the frequency range 1-250 Hz. Along the sleeper, secondary longitudinal and transverse waves arise due to the “transfer” of the energy of the main longitudinal wave into the transverse along the sleepers. As a result, circulation flows along the length of the sleeper occurred as well as irreversible deformation of the prism and the accumulation of defects in the subgrade, the porosity and the probability of splashes of ballast are increased. The best damping and cost properties have constructions with crushed stone in comparison with a ballastless design. However, the stability of the motion on the ballast prism and its inter-repair period depends on the correct organization of drains, especially in spring and autumn. Developed apparatus for determining the degree of stress damping in the structure of the track subgrade and the superstructure can be used to develop a normative document for selecting the design of the subgrade structure of the track, depending on the geological, climatic conditions and the average annual groundwater level. The use of the apparatus of linear harmonic analysis is explained by the fact that the influence of nonlinear effects of wave propagation in dispersed materials does not have time to appear because of the extremely small thicknesses of materials constituting the subgrade.
Studies of the constructed rail seat supports
Authors: Khvostik M. Yu. , Starodubtseva M. A.
Published: October 2018

In recent decades, the use of constructed sleepers on the world's railways has been increasing: the United States, the EU countries, Japan and China. Such sleepers, having positive performance qualities of wooden sleepers (good elasticity and dielectric properties, manufacturability during laying and during repair work), do not have negative qualities of wood. The article reviews the US and EU standards for testing sleepers made of constructed materials. The classification of such sleepers is given. Examples of testing of such sleepers by specialists of JSC “VNIIZhT” for the period from 1999 to 2016 are given, including sleepers from modified wood, wooden sleepers with elastomeric coating, composite sleepers from recycled high-density polyethylene with glass-filled polymer. Features of the Russian requirements to the constructed sleepers are considered. Composite rail seat supports are promising in application. Possessing the advantages of wooden sleepers (bars), they have higher wear resistance, lower life cycle costs (recyclable), are more homogeneous and do not rot. Damping properties of composite sleepers contribute to solving the problem of reducing noise and vibration from rolling stock. In addition, their use is one of the ways to reduce the negative impact of rail transport on the environment. With a feasibility study, such sleepers will successfully replace other types of rail seat supports. Spheres of rational application of composite rail seat supports are heaving sections of the railway track, areas with weak soils, turnouts, tracks on bridges, railway tunnels, and underground tracks. Taking into account the tendency to expand the polygon for laying composite sleepers, including railway tracks, metro routes and land transport in the Russian Federation, Kazakhstan and other CIS countries, it is advisable to develop a single interstate standard containing safety requirements and test methods for constructed rail seat supports.
Mathematical modeling of aerodynamic behavior of antenna-mast structures when designing communication on railway transport
Authors: Loktev A. A. , Korolev V. V. , Poddaeva O. I. , Stepanov K. D. , Chernikov I. Yu.
Published: October 2018

Due to the development of high-speed operation, the problem of providing high-quality communication channels for train passengers, control and security systems, caused by the difﬁculty of fast positioning of the carriage, the large Doppler extension of the transmitted signal and the increasing amount of data transferred, is becoming especially topical at present. Two solutions can be conceptually possible in order to increase the coverage area near the railroad right-of-way: installation of a set of relatively small antennas of transmitting stations along the track or installation of powerful transmitters on high antenna-mast structures. Communication facilities exceeding 75 m are classiﬁed as particularly dangerous, technically complex communication facilities, and communication facilities exceeding 100 m, - as unique facilities. According to normative legal documents for structures classiﬁed as particularly dangerous, technically complex or as unique objects, it is necessary to additionally determine the aerodynamic coefﬁcients by blowing structures in wind tunnels or by recommendations developed by specialized organizations. In view of the above, it is relevant to solve the problem of developing recommendations for the determination of aerodynamic coefﬁcients and its approval as a guiding regulatory and technical document. This study is devoted to the development of a mathematical model for the behavior of an antenna-mast structure under wind inﬂuence, which would allow determining the aerodynamic coefﬁcients when collecting loads on newly designed or currently ope rated structures, and also adequately predict the behavior and condition of the object at various stages of the life cycle.
Simulation model for determining the rational dimensions of the irreducible reserve of locomotives at the stations of its turnover
Authors: Sotnikov E. A. , Gonik M. M. , Khomyakov S. V. , Mikhaylov S. V.
Published: October 2018

With the introduction of polygon site technologies, the extension of locomotive circulation areas has increased the complexity of solving the problems of regulating the fleet of locomotives. Determination of the required rational size of the irreducible reserve of locomotives at the stations of its turnover is currently carried out in order to extinguish the influence on the export of the inaccuracies in the planning and inadequate depth of the forecast of the car traffic flows. Substantially this determination is made on the basis of expert assessments and does not have sufficient methodological justification. In order to exclude the loss of the traffic threads in the schedule, it is necessary to create a rational irreducible reserve of locomotives at the stations of its turnover. To solve this problem, a mathematical model of train operation has been developed on locomotive circulation areas, taking into account the daily fluctuations of train traffic, possible deviations in predicting composition formation and other factors. Performing mass calculations for various conditions will allow determining the rational size of the irreducible reserve of locomotives at the stations of its turnover and eliminate the losses associated with the cancellation of the schedule threads due to the lack of provision of finished trains by locomotives. Extensive full-scaled tests were made to determine the difference between actual and planned train traffic, which allowed determining regularities in the formation of planned values of train traffic for use in the simulation model. An algorithm for constructing a simulation model has been developed that provides for the amount of a irreducible reserve of locomotives for different conditions: changing values of the average daily train traffic in the even and odd directions of traffic, traffic incompatibility, the degree of uneven daily traffic, errors in planning (planning quality), etc. The software of the simulation model was developed and its debugging was made to perform mass calculations. The study of the problem of determining the rational size of the irreducible reserve of locomotives at the stations of its turnover was carried out with the support of the Russian Railways and the Russian Foundation for Basic Research. Project No. 17-20-01136.
Potential for the use of heat pumps for heat supply of metro stations
Authors: Naumenko S. N. , Minaev B. N. , Rebrov I. A. , Gusev G. B.
Published: October 2018

At present, specialists of foreign and domestic research organizations and industrial firms pay much attention to the use of steam compression heat pump plants (HPP) as an energy-saving technology. Modern compressor units allow receiving 3-4 kW for 1 kW of power consumed by HPP, and under certain conditions up to 5-6 kW of useful power. Today HPPs are most used in heat supply systems for residential and office buildings, especially in Scandinavia, Germany, Switzerland, USA, Japan, China. The paper discusses features of the operation of steam compressor heat pump plants as systems for improving energy efficiency with a description of the device of a heat pump plant; its main components are also listed. Review of the existing practice of introducing such systems in foreign countries is presented, including in Minsk - the Minsk metro, and in Russia - the Moscow Metro. The project, performed by specialists of JSC “VNIIZhT” and MIIT, is considered for the Moscow Metro (with reference to the heating systems of the Nagatinskaya and Pushkinskaya metro stations) for the use of dumping heat of ventilation shafts for heating and hot water supply, proposed by scientists of JSC “VNIIZhT” in 2012 within the framework of the exhibition of technical achievements. Authors presented information on the implementation of the pilot project at the station “Salar’yevo” (Moscow Metro) on the use of HPP in the heat and cooling supply system of the station for further comprehensive analysis of the effectiveness of the HPP application in the operating conditions of the metro. From the analysis of the data given in the work, it is concluded that metro systems are significant sources of low-potential heat, which can be used for the heat supply of stations and/or nearby urban sites by means of HPP. By now, there is a lot of experience (especially abroad) of the practical application of HPP in the heat supply systems of facilities. Nevertheless, for a reliable and comprehensive assessment of the feasibility and cost-effectiveness of projects using low-potential heat of metro systems as an energy-saving technology, a complex of studies is needed, including operational tests of currently implemented pilot projects.
City Architecture as the Production of Urban Culture: Semiotics Review for Cultural Studies
Authors: Susilo Daniel , Primatama Mega
Published: October 2018

This article aims to describe correlation between city's architecture as urban culture and cultural studies, specifically in semiotics. This article starts from Chris Barker's statement about city and urban as text in his phenomenal book, Cultural Studies, Theory and Practice. City as a complex subject has been transformed as the representation of urban culture. In the post-modernism view, urban culture as cultural space and cultural studies' sites have significantly pointed to became communications discourse and also part of the identity of Semiology. This article uses semiotics of Saussure for the research methods. Surabaya and Jakarta has been chosen for the objects of this article. The result of this article is describing the significant view of architecture science helps the semiotics in cultural studies. In other way, city's architecture becomes the strong identity of urban culture in Jakarta and Surabaya. Architecture approaches the cultural studies to view urban culture, especially in symbol and identity in the post-modernism era.
Fake Barns and Our Epistemological Theorizing
Authors: García Rodríguez Ángel
Published: October 2018

Pure virtue epistemology faces the fake barn challenge. This paper explains how it can be met. Thus, it is argued that the thought experiment contains a hidden ambiguity concerning the visual ability typically ascribed to, or denied, fake barn subjects. Disambiguation shows fake barn subjects to have limited knowledge of the target proposition (e.g. that there is a barn ahead). This accords with a pure virtue-theoretic conception of knowledge that predicts and explains all the intuitionselicited by the thought experiment. As a result, the relationship between knowledge, luck and ability is illuminated, and our epistemological theorizing improved.
Kesuksesan Knowledge Transfer Di Laboratorium Perguruan Tinggi Melalui Pengelompokkan Rekan Kerja Menggunakan Agent-Based Modeling And Simulation
Authors: Ramadhan Fadillah , Rizana Afrin Fauzya , Rispianda R , Yuniati Yoanita
Published: October 2018

One of aspect that contributes to improving organizations performance is knowledge transfer effectiveness. On the other hand, knowledge transfer is a dynamic interaction between people, process, and environment so that activity related to knowledge transfer categorized as a complex and adaptive process. The use of agent-based modeling and simulation approach is very appropriate in modeling knowledge transfer due to its ability to deal with the dynamic, complex, and adaptive process. Moreover, the agent-based approach has the ability in describing the interaction between the social agent that possess particular behavior. The purposes of this study are to identify the factors that influence the success of knowledge transfer in the university laboratory. In addition, the results show that agent-based modeling and simulation approach can determine the best scenario that can increase the success of knowledge transfer based on grouping of colleagues.
The awareness of obesity associated comorbidities among normal weight, overweight and obese individuals: a cross sectional analysis
Authors: AYAR Koray , KOCA Nizameddin , ERSOY Canan
Published: October 2018

Introduction: Obesity is one of the most important community health
threatening problem, because of its high prevalence and associated
comorbidities. Each of these comorbidities have various risks for health. There
are very few studies investigating the awareness of people about obesity
associated comorbiditiesMethods: Five-hundred adult patients, admitted to Endocrinology
& Internal Medicine outpatient clinics, whose body mass index was>18.5
kg/m2 and completed a questionnaire concerning obesity associated
comorbidities were included in this study. Each correct answer was scored as 1
point. Each participant’s total score and mean total score (MTS) was
calculated. The scores among normal weight, overweight
and obese groups were compared. Besides the questionnaire, age, gender,
education level was asked and waist and hip circumference, height and weight
were measured by the researchers.Results: Mean education score
was the lowest in the obese group, altough MTS was the highest. Awareness of obesity associated stroke, breast cancer
and osteoarthritis were significantly higher in the obese group when compared
to the other groups, but there was no difference between men and women. Awareness
of obesity associated menstrual irregularity and infertility was higher in
women, hypertension and prostate cancer was higher in men.

Conclusions: Although the education level was lowest in the obese
group, the awareness of obesity-associated comorbidities was highest.
Гипотеза о «заградительном ряде» для дзета-функций моноидов с экспоненциальной последовательностью простых
Authors: Добровольский Н. Н. , Добровольский М. Н. , Добровольский Н. М. , Балаба И. Н. , Реброва И. Ю.
Published: October 2018

В работе продолжено изучение нового класса рядов Дирихле — дзета-функции мо­ноидов натуральных чисел. Прежде всего детально изучена дзета-функция ????(M(g)|a) геометрической прогресс М(q) с первым членом равным 1 и произвольным натураль­ным знаменателем q > 1, которая является простейшем моноидом натуральных чисел с однозначным разложением на простые элементы моноида. Для мероморфной функции ????(M(g)|a) = qa/qα -1, имеющей множество полюсов

S(M(q)) ={2πikl/lnq│k ∈Z}

получены представления:

ζ(M(q)|α) = ∞ ∏︁ n=1(1 + α2 ln2 q 4π2n2 )︂−1 = 1 2 + 1 αlnq + ∞ ∑︁ n=1 2αlnq α2 ln2 q + 4n2π2 = = q α 2 αlnq 4π2 Γ(︂αilnq 2π )︂Γ(︂−αilnq 2π )︂.

Для дзета-функции ζ(M(p~)|α) моноида M(p~) с конечным числом простых чиселp~ = (p1,...,pn) получено разложение в бесконечное произведение

ζ(M(p~)|α) =P(p~)α 2 αnQ(p~)n ∏︁ ν=1∞ ∏︁ m=1(︂1 + α2 ln2 pν 4π2m2 )︂−1 ,

где P(p~) = p1 ...pn, Q(p~) = lnp1 ...lnpn, и найдено функциональное уравнение ζ(M(p~)|−α) = (−1)n ζ(M(p~)|α) P(p~)α .

Для моноида натуральных чисел M*(p~) = N · M−1(p~) с однозначным разложением на простые множители, состоящим из натуральных чисел n взаимно простых с P(p~) = p1 ...pn, и для эйлерово произведение P(M*(p~)|α), состоящего из сомножителей по всем простым числам отличным от p1,...,pn, найдено функциональное уравнение ζ(M*(p~)|α) = M(p~,α)ζ(M*(p~)|1−α), где M(p~,α) = M(α)· M1(p~,α) M1(p~,1−α) , M1(p~,α) = n ∏︁ ν=1(︂1− 1 pα ν)︂.

Доказано, что для любого бесконечного множества простых P1 не существует аналитической функции равной lim n→∞ ζ(M(p~n)|α) на всей комплексной плоскости.

Сформулирована гипотеза о заградительном ряде для любого экспоненциального множества PE простых чисел.

В заключении рассмотрены актуальные задачи с дзета-функциями моноидов натуральных чисел, требующие дальнейшего исследования.
Многообразия с дробным полиномиальным ростом и проблема Шпехта
Authors: Мищенко С. П. , Шулежко О. В.
Published: October 2018

Совокупность линейных алгебр, в которых выполняется фиксированный набор тождеств, следуя А.И. Мальцеву, называется многообразием. Используя язык теории алгебр Ли будем говорить, что алгебра метабелева, если она удовлетворяет тождеству (xy)(zt) ≡ 0. Многообразие называется шпехтовым, если оно само и любое его подмногообразие обладает конечным базисом тождеств. Рост многообразия определяется ростом последовательности размерностей полилинейных частей относительно свободной алгебры многообразия. Эту последовательность традиционно называют последовательностью коразмерностей, имея в виду полилинейные пространства идеала тождеств многообразия. В данной статье приведены результаты связанные с проблемой дробного полиномиального роста. Дается обзор новых примеров таких многообразий, а также приводятся новые примеры многообразий, которые не удовлетворяют свойству шпехтовости, то есть которые обладают бесконечно базируемыми подмногообразиями.
Дифракция плоской звуковой волны на двух упругих цилиндрах с неоднородными покрытиями
Authors: Толоконников Л. А.
Published: October 2018

В статье получено аналитическое решение задачи дифракции плоской звуковой волны на двух однородных упругих цилиндрах с радиально-неоднородными покрытиями, находящимися в идеальной жидкости. Волновые поля в содержащей среде и однородных упругих телах находятся аналитически, а для нахождения полей смещений в неоднородных покрытиях построена краевая задача для системы обыкновенных дифференциальных уравнений второго порядка.

С помощью непрерывно-неоднородных упругих покрытий можно эффективно изменять характеристики рассеяния тел в определенных направлениях, если подобрать соответствующие законы неоднородности для механических параметров покрытия. Задача представляет интерес для изучения дифракции звука на решетке цилиндрических тел, а также служит необходимым элементом решения методом мнимых источников задачи о дифракции звука на одиночном однородном упругом цилиндре с неоднородным покрытием, находящемся вблизи акустически мягкой или абсолютно жесткой плоской поверхности.
COMPETÊNCIAS DO PROFISSIONAL ENFERMEIRO NO CONTEXTO DA ATENÇÃO BÁSICA
Authors: Girlane Sousa Albuquerque Brandão Maria , Aline Moreira Ximenes Maria , Moreira Barros Lívia
Published: October 2018

O objetivo deste estudo foi analisar as competências profissionais do enfermeiro para a prestação de cuidados no âmbito da Atenção Básica. Trata - se de uma pesquisa bibliográfica, do tipo revisão integrativa, realizada por meio das bases de dados LILACS, BDENF e MEDLINE, disponíveis na Biblioteca Virtual em Saúde, no intervalo temporal de 2011 a 2016. Os resultados mostraram que existe um consenso em relação ao fato de que o enfermeiro tem perfil generalista, pois além de poder ter atribuições de coordenação, o enfermeiro deve agregar as atividades de assistência à saúde, exercendo múltiplas competências, como: gestão, consulta de enfermagem, puericultura, coordenar os agentes comunitários de saúde e auxiliares de enfermagem, educação permanente, visita domiciliar e preceptoria de enfermagem. Assim, o enfermeiro tem o desafio de desempenhar uma gama de atividades, visando à assistência holística e qualificada de enfermagem ao paciente, tornando-se essencial a aquisição de competências, buscando aperfeiçoar os conhecimentos, habilidades e atitudes a fim de aprimorar o seu processo de trabalho.
PERFIL CLÍNICO DAS MULHERES IDOSAS EM PÓS-OPERATÓRIO INTERNADAS EM CENTRO DE TERAPIA INTENSIVA
Authors: Serrano Vilalba Marina , Penido Matozinhos Fernanda , Mendes de Souza Rocha Izabella , Philipe Rodrigues da Silva Thales
Published: October 2018

Objetivou-se identificar o perfil clínico das mulheres idosas provenientes do bloco cirúrgico, internadas no Centro de Terapia Intensiva de um Hospital Público de Belo Horizonte. Trata-se de uma pesquisa transversal. As coletas de dados foram realizadas por meio de prontuários eletrônicos das pacientes. A amostra consta de 53 mulheres idosas. A idade média foi de aproximadamente 78 anos (±11,0). O tempo médio de internação foi de 6 dias (±7,8). As principais causas da admissão hospitalar foram: fraturas pertrocantérica (32,1%), doenças cardiovasculares (24,5%), neurológicas (17,0%) e infecciosas (9,4%). Nove mulheres idosas (20,9%) possuíam lesão por pressão. Das 53 mulheres idosas, 39 (73,6%) receberam alta para outros setores, 12 (22,6%) evoluíram para óbito e 2 (3,7%) foram transferidas para outras Instituições. Nos últimos anos, avanços foram realizados sobre a saúde das mulheres idosas. Esse grupo populacional necessita de linhas de cuidados específicas nas políticas de saúde e exige do sistema de saúde e dos profissionais cuidados cada vez mais diferenciados.
O PERFIL DOS INTERNOS DE UM HOSPITAL DE CUSTÓDIA E TRATAMENTO PSIQUIÁTRICO: PERSPECTIVAS DA REFORMA PSIQUIÁTRICA NO BRASIL
Authors: Cristina Ribeiro Mara , Cleonice Santos de Souza Marilya , Vieira da Silva Eline , Nunes de Magalhães Murillo , Maika da Rocha Vieira Nailena
Published: October 2018

O objetivo deste estudo foi analisar as competências profissionais do enfermeiro para a prestação de cuidados no âmbito da Atenção Básica. Trata - se de uma pesquisa bibliográfica, do tipo revisão integrativa, realizada por meio das bases de dados LILACS, BDENF e MEDLINE, disponíveis na Biblioteca Virtual em Saúde, no intervalo temporal de 2011 a 2016. Os resultados mostraram que existe um consenso em relação ao fato de que o enfermeiro tem perfil generalista, pois além de poder ter atribuições de coordenação, o enfermeiro deve agregar as atividades de assistência à saúde, exercendo múltiplas competências, como: gestão, consulta de enfermagem, puericultura, coordenar os agentes comunitários de saúde e auxiliares de enfermagem, educação permanente, visita domiciliar e preceptoria de enfermagem. Assim, o enfermeiro tem o desafio de desempenhar uma gama de atividades, visando à assistência holística e qualificada de enfermagem ao paciente, tornando-se essencial a aquisição de competências, buscando aperfeiçoar os conhecimentos, habilidades e atitudes a fim de aprimorar o seu processo de trabalho.
Thermodynamic properties of formation estimated to biodiesel esters using Gaussian quantum chemistry software and group contribution method of Constantinou and Gani
Authors: Potrich E. , Voll F.A.P. , Cabral V.F. , Filho Cardozo
Published: October 2018

A lot of recent research has focused on the study of biocatalysts and nanocatalysts to improve biodiesel production. However, knowledge of the thermodynamic properties of the reaction components is necessary. In this work, the enthalpy of formation and Gibbs free energy of formation for methyl to pentyl esters were calculated using the Gaussian quantum chemistry software (model B3LYP/6-31G(d, p)) and the group contribution method of Constantinou and Gani (MCG). The values obtained by both methodologies present certain differences in relation to the values in the literature. Thus, three correction parameters, which were based on the number of atoms of 26 different molecules, were estimated by minimizing the error function and later used to extrapolate the results to larger molecules of interest. After the use of the correction parameters, the mean deviation between the experimental and calculated values by Gaussian was 0.723% for enthalpy and 1.087% for Gibbs, whereas for MCG, it was 1.324 and 2.540%, respectively. As the methodology proved to be efficient, the thermodynamic properties of the formation of 23 esters that compose the biodiesel were estimated. These properties are of great importance, mainly for the calculation of chemical equilibrium and reaction data in the development of new catalysts.
Correlation between damage evolution, structural and optical properties of Xe implanted CrN thin films
Authors: Popovic Maja , Novakovic Mirjana , Zhang Kun , Mitric Miodrag , Bibic Natasa , Rakocevic Zlatko
Published: October 2018

Polycrystalline CrN thin films were irradiated with Xe ions. The
irradiation-induced modifications on structural and optical properties of the
films were investigated. The CrN films were deposited on Si(100) wafers with
the thickness of 280 nm, by using DC reactive sputtering. After deposition,
the films were implanted at room temperature with 400 keV Xe ions with the
fluences of 5-20?1015 ions/cm2. The films were then annealed at 700 ?C in
vacuum for 2 h. The combination of Rutherford backscattering spectrometry
(RBS), X-ray diffraction (XRD) and transmission electron microscopy (TEM) was
used for structural analyses, while changes in optical properties were
monitored by spectroscopic ellipsometry. We also measured the electrical
resistivity of the samples using a four point probe method. RBS analysis
reveals that the concentration of Xe in the layers increases with ion fluence
reaching the value of around 1.5 at.% for the highest ion dose, at a depth of
73 nm. XRD patterns show that the irradiation results in the decrease of the
lattice constant in the range of 0.4160-0.4124 nm. Irradiation also results
in the splitting of 200 line indicating the tetragonal distortion of CrN
lattice. TEM studies demonstrate that after irradiation the columnar
microstructure is partially destroyed within _90 nm, introducing a large
amount of damage in the CrN layers. Spectroscopic ellipsometry analysis shows
that the optical band gap of CrN progressively reduces from 3.47 eV to 2.51
eV with the rise in ion fluence up to 20?1015 ions/cm2. Four point probe
measurements of the films indicated that as the Xe ion fluence increases, the
electrical resistivity rises from 770 to 1607 ?Wcm. After post-implantation
annealing crystalline grains become larger and lattice distortion disappears,
which influences optical band gap values and electrical resistivity of CrN.
Synthesis of novel hard/soft ferrite composites particles with improved magnetic properties and exchange coupling
Authors: Tavakolinia Faezeh , Yousefi Mohammad , Afghahi Seyyed , Baghshahi Saeid , Samadi Susan
Published: October 2018

SrFe12O19/Zn0.4Co0.2Ni0.4Fe2O4 hard/soft ferrite composite particles with 20,
40, 60 and 80 wt.% of soft phase were prepared by one-pot sol-gel
auto-combustion and physical mixing methods. Fourier transform infrared
spectroscopy (FTIR), X-ray diffraction (XRD), field emission scanning
electron microscope (FESEM) and vibrating sample magnetometer (VSM) were
used to characterize the structural and magnetic properties of the samples.
XRD spectrum revealed the formation of mixed ferrite phases in the composite
particles. The hysteresis loops of the samples showed the presence of
exchange coupling between the hard and soft ferrites. The composite
particles with 20 and 60 wt.% of the soft phase demonstrated the highest
Mr/Ms ratio, i.e. 0.29 and 0.28, respectively. In addition, the highest Ms,
Mr and Hc were achieved in the composite particles with 40, 60 and 20 wt.%
of the soft phase, respectively. Compared to the physical mixing method
(PM), the composite particles prepared by the sol-gel auto-combustion method
(OP) demonstrated better magnetic properties. The exchange coupling
interaction between the hard and soft ferrite phases was similar in both
methods. These composite particles exhibited magnetically single phase
behaviour, however, the saturation magnetization was lower in the physical
mixing pared to that of the one-pot method.
Facile molten salt synthesis of zirconia whiskers
Authors: Wang Tao , Liu Jianmin , Jiang Weihui , Feng Guo , Miao Lifeng , Chen Ting , Wu Qian , Tang Huidong , Luo Wei
Published: October 2018

ZrO2 whiskers have been synthesized by a facile molten salt method using
ZrOCl2 ? 8H2O and Na3PO4 ? 12H2O as the zirconium source and molten salt,
respectively. Differential thermal and thermogravimetric analyses, Xray
diffraction analysis, field emission scanning electron microscope and
transmission electron microscope were employed to characterize the heating
process of the precursor mixture, phase composition of the assynthesized
ZrO2 whiskers and the effect of reaction temperature on the synthesis of
ZrO2 whiskers. The results show that the ZrO2 whiskers synthesized at 900?C
have an average aspect ratio of 30 and preferentially grow along [010]
direction. The formation of sodium zirconium phosphate [Na9-4xZrx(PO4)3] (x
= 1, 2) and the reaction temperature play an important role in the growth of
ZrO2 whiskers. This work also suggests an effective route for mass
production of high quality ZrO2 whiskers.
Effect of carbon-coated Al2O3 powder on structure and properties of low-carbon MgO-C refractory composites
Authors: Tian Xiangyu , Liu Guoqi , Shang Xinlian , Li Hongxia , Wang Xinfu , Yang Wengang , Chen Yongqiang
Published: October 2018

In this study, low-carbon MgO-C refractory composites with addition of
uncoated (UA) and carbon-coated Al2O3 (CCA) powders were prepared. The
effect of heat-treatment temperature on apparent porosity, cold modulus of
rupture and thermal expansion was investigated. The results indicated that
the CCA was present in the form of porous agglomerates of 400-800 ?m in
diameter in MgO-C matrix. The formation of spinel started at 1100?C and
1250?C in UA-MgO-C and CCA-MgO-C specimens, respectively. In the specimen
CCA-MgOC, cyclic spinel was formed on the outer layer of CCA agglomerates,
and the dense spinel layer hindered the diffusion of Mg(g) to the interior
of the agglomerates, resulting in alumina residues at 1550?C. The specimen
CCA-MgO-C showed better mechanical properties and reduced porosity.
Additionally, the average coefficient of thermal expansion of CCA-MgO-C was
significantly lower than that of UA-MgO-C. Thus, CCA powder could improve
the volume stability of the low-carbon MgO-C refractory composites.
Demystifying McCarthy’s 4 P’s of the Marketing Mix: To Be or Not to Be
Authors: Beke Grace O.
Published: October 2018

Jerome McCarthy's 4 P’s theory is being appraised in this research paper from a chronological and logical standpoint. McCarthy's theory has been extensively utilized as an instructional device by marketing experts and scholars since its debut in 1960 but despite its advantages, it academic critics have constantly criticized it. The 4 P’s paradigm criticisms are reviewed and resolved that it has demonstrated that the theory is strong to be implemented in present day marketing applications. This is to say that McCarthy theory/model is immemorial. Its validity still stands despite being designed decades ago.
ANALISIS KARYA SISWA DALAM MENGGAMBAR MANUSIA DITINJAU DARI ASPEK ANATOMI DAN PROPORSI PADA KELAS VIII SMP NEGERI 1 TANJUNG BALAI TAHUN AJARAN 2016/2017
Authors: Aulia Aulia , Sihite Onggal
Published: October 2018

ABSTRAK Penelitian ini bertujuan untuk mendeskripsikan hasil karya siswa dalam menggambar manusia, pada mata pelajaran seni budaya di SMP Negeri 1 Tanjung Balai. Populasi penelitian ini adalah keseluruhan karya siswa kelas VIII SMP Negeri 1 Tanjung Balai yang berasal dari 10 kelas berjumlah 339 karya, sedangkan sampel penelitian diambil dengan teknik Random Sampling, yaitu dengan mengacak kelas sehingga terpilih kelas VIII2 yang berjumlah 26 karya. Pada penelitian menunjukkan: 17 (65,38%) karya dapat menampilkan anatomi manusia cukup tepat, 9 (34,61%) karya dapat menampilkan anatomi manusia tidak tepat, 16 (61,53%) karya dapat menampilkan proporsi manusia cukup tepat dan 10 (4,34%) karya menampilkan proporsi manusia tidak tepat dari 26 siswa. Kesimpulan dari hasil karya siswa sudah menampilkan hasil yang cukup tepat terlihat dari bentuk anatomi dan proporsi walaupun tidak semua mampu memenuhi kriteria gambar yang diinginkan. Saran bagi pendidik untuk lebih banyak menambah pembelajaran dan pengadaan referensi tentang anatomi dan proporsi.            Kata Kunci: menggambar manusia, anatomi, proporsi
KEMAMPUAN MAHASISWA DALAM MEMAHAMI BACAAN PADA BUKU TEKS MATEMATIKA BERBAHASA INGGRIS
Authors: Indahwati Rohmah , Sa'adiyah Evha Nazalatus
Published: October 2018

English Mathematics course mostly deals with comprehension questions, grammar and vocabulary related to the field of Mathematics. The goal is that students have the confidence in communicating using English as well as utilize various sources of English teaching materials. But in reality, they usually experience several problems as the medium of instruction changes from their mother tongue to another language. This phenomenon in the case of Mathematics education brings the consequences faced by Mathematics educators. This paper describes the understanding of Mathematicsematical concepts in English textbooks (Fraction) on the students of English Mathematics Study Course of Mathematics Education of Madura University. The data that used in this research is the result of the translation scripts of students at the Mathematics education department on the fractional concepts in English textbooks, observations on the student presentation and interviews. The result of this research are, Subjects still have not been able to understand the meaning of fractions that are linked in real objects and clear Mathematicsematical models., subjects still used word-for-word translation, translating without providing meaningful information and also lack of vocabulary.
STUDENTS’ THINKING PROCESS IN CREATING SCHEMATIC REPRESENTATION
Authors: Anwar Rahmad Bustanul , Rahmawati Dwi
Published: October 2018

The aim of this study is to describe students’ thinking process in creating schematic representation. A describtive qualitative research is used in this paper along with case study approach. The examined case is students’ thinking process in creating schematic representation in solving word problem. The subjects are Junior High School students at grade VIII. Data collection were done by think aloud technique and interview. The result show that students’ thinking process in creating schematic representation is retrieved from processing theory started by taking the problem into account. Students read the problem based on its intonation with stress in each sentence. Then, students create a scheme and link all information they understand about. This scheme later is drawn into triangle form. By creating the scheme, students are able to comprehend the questions and problems proper. Students connect problems faced by theirself with the concept of Phytagoras stored in long-term memory. The students' understanding of the Phytagoras Theorem concept is well preserved so that students can solve the problem appropriately.
PENGEMBANGAN MULTIMEDIA PEMBELAJARAN BERBASIS COGNITIVE LOAD THEORY (CLT) PADA MATERI VOLUME KUBUS DAN BALOK DI SEKOLAH DASAR
Authors: Kurniawati Rissa Prima , Hadi Fida Rahmantika , Rulviana Vivi
Published: October 2018

This research aims to describe the development of interactive learning multimedia based on cognitive load theory (CLT) in the fifth grade of elementary school. This type of research is research and development (R & D). The methods of collecting the data in this research were questionnaires, and interviews. This questionnaire is used to determine the response of students after using interactive multimedia based on CLT. Meanwhile this interview was conducted to find out the responses, comments, and suggestions of teachers and students after using interactive multimedia based on CLT. The validity of the results of the validation data analysis from this material expert was 87.50% and the validity of the validation data from this media expert was 85.71%. It shows that the material in CLT-based learning multimedia is valid and ready to be implemented. And the average questionnaire score at SDN 3 Taman was 88.27%, so the results of the questionnaire were declared good. The advantages of this CLT-based interactive learning multimedia are this multimedia display is very interesting, the material is presented more interesting, and the menus that are presented are easy to understand.
The fight against social diseases in the 1920s: a case study of Nizhny Novgorod Territory and the Autonomous Tatar Socialist Soviet Republic
Authors:   Privolzhsky Research Medical University of  the Ministry of Health of the Russian Federation, Kezhutin Andrey Nikolaevich
Published: October 2018

The study reveals the regional circumstances of the fight of the government and the community against the sexually transmitted diseases and tuberculosis as a public health hazard in the Nizhny Novgorod Territory and the Autonomous Tatar Socialist Soviet Republic (ATSSR) in the 1920s. The research is based on national and regional archives and local periodicals. The author identifies the social and economic reasons for the widespread social diseases, the collaborative arrangements of the authorities and the society to overcome them. Data on the health situation in ethnic regions are introduced. It was concluded that in the 1920s, the regions under review had the similar environment for the mass spread of social diseases due to the extreme transition period. They struggled with social diseases in the same way. Besides, the state collaborated effectively with the society to overcome such diseases.
Teleology as a way of thinking of history and its alternatives
Authors: Alferov Anatoly Aleksandrovich ,   Southern Federal University
Published: October 2018

The study examines the goal setting of history in the developing context of philosophical and scientific thought. It identifies the determinants of the desire of the traditional philosophy of history to coordinate history in relation to the purpose. The research demonstrates that the idea of the predetermined goal of history is a manifestation of the transcendental thinking of history. Such a goal is always a certain transcendental factor introduced into history. The study correlates the idea of the historical purpose with the idea of the historical necessity. The author notes that criticism in relation to the teleological view of history should not lead to the conclusion that any idea of the goal as applied to history is unjustified. It is possible that we will set the historical goals for ourselves and try to implement them. The absence of a transcendental goal setting in history leaves a wide room for human goal setting. The paper considers the prerequisite for the possibility of achieving historical purposes by people. The ability of a person to set historical goals and achieve them is defined as human freedom in history.
Model Keamanan pada Virtual Local Area Network (VLAN) untuk Mengatasi DHCP Rogue
Authors: Bayu Teguh Indra , Nurhanif Nurhanif
Published: October 2018

Keamanan jaringan di era ini sangat dibutuhkan, dibalik kemudahan dalam mengakses informasi terdapat pula banyak ancaman. Dengan aplikasi GNS3 pengguna dapat membuat simulasi jaringan dengan perangkat yang dibutuhkan seperti aslinya serta dalam perangkat dapat dikonfigurasi langsung. Pada simulasi ini membuat Perancangan Keamanan pada Virtual Local Area Network (VLAN) untuk Mengatasi DHCP Rogue dengan penggunaan ACL solution serta trusted-servers yang menjadi salah satu cara agar menjadikan jaringan tersebut tetap aman dan stabil. Dari hasil penelitian yang dilakukan GNS3 mampu Merancangan Keamanan Virtual Local Area Network (VLAN) untuk Mengatasi DHCP Rogue dengan memasukkan ACL solution serta fitur trusted-servers ke dalam switch ExtremeXOS.