bluuebunny/crossref_metadata_2025 huggingface dataset:
XRD, SEM, FTIR Analizleri ve BET Yöntemiyle Zeolitlerin Karakterizasyonu ve Isıl İşlem Görmüş Zeolitlerin Yüzey Asidik Özelliklerinin Belirlenmesi
Authors: Bilgiç Ceyda , Bilgiç Şafak
Published: August 2023

Zeolitlerin özellikle iyon değiştirici, katalizör ve adsorban olarak etkin kullanımları için yüzey özelliklerinin bilinmesi gerekmektedir. Bu çalışmada zeolitlerin morfolojik, mineralojik ve yüzey özellikleri, X-ışını kırınım deseni (XRD), Taramalı Elektron Mikroskobu (SEM), Fourier Dönüşümlü Kızılötesi Spektroskopisi (FTIR) ve Brunauer-Emmett-Teller (BET) yöntemlerinin birlikte kullanıldığı enstrümantal analiz teknikleriyle incelenmiştir. FTIR spektrumlarından, zeolit yüzeylerinde silanol ve hidroksil köprülerinin varlığı kanıtlanmıştır. Zeolitlerin yüzey alanı, gözenek hacmi, gözenek boyut dağılımı ve ortalama gözenek çapı dâhil gözenek özellikleri, BET t-plot ve yoğunluk fonksiyonel teorisi (DFT) yöntemleri kullanılarak 77 K'de N2 adsorpsiyonu ile belirlenmiştir. Gözenek boyut dağılımı, zeolitlerin hem mikro hem de mezo gözenekler içerdiğini göstermiştir. Farklı SiO2/Al2O3 oranlarına sahip zeolitlerin, Si/Al oranı arttıkça özgül yüzey alanında azalma gözlenmiştir. Isıl aktivasyona uğratılmış zeolitlerin yüzey asitlikleri farklı iki yöntem kullanılarak belirlenmiştir. n-Bütilamin titrasyon yöntemiyle zeolitler üzerindeki asit bölgelerinin toplam miktarı ve FTIR spektrumlarından, yüzey asitlikleri hakkında bilgi sağlanmıştır.
CONSTRUCTION OF THE HIGH-VELOCITY MODEL OF THE EARTH’S UPPER CRUST OF THE EURASIAN AND OKHOTSK SEA PLATES CONJUNCTION ZONE ALONG THE NORTH-EASTERN SEGMENT OF THE 3-DV PROFILE BASED ON THE RESULTS OF DIGITAL PROCESSING OF COMPRESSIONAL- AND SHEAR-WAVE REFRACTIONS
Authors:   Altai-Sayan Branch of Federal State Budgetary Institution of Science of the Geophysical Service of the RAS, Novosibirsk, Russia, Polyanskiy P. O. , Emanov A. F. ,   Altai-Sayan Branch of Federal State Budgetary Institution of Science of the Geophysical Service of the RAS, Novosibirsk, Russia, Salnikov A. S. ,   Siberian Research Insitute of Geology, Geophysics and Mineral Resources, Novosibirsk, Russia
Published: August 2023

An automated algorithm for monitoring the areas of refraction event tracking along the profile based on the dynamic conversion method is developed. Time sections of compressional - and shear-wave refractions recorded by the CDP shooting geometry on the North-Eastern segment of the 3DV survey base line are constructed. A high-speed model of the upper part of the Earth’s crust is constructed to depths of ≈2 km in the conjunction zone of the Okhotsk and Eurasian lithospheric plates. According to increased values of the velocity ratio of P- and S- waves, it is found that refracting boundaries in the Ayan-Yuryakh block are sections of rocks with various lithological composition in sedimentary cover. The zone of reduced values of P-wave velocity and the VP /Vs ratio associated with a high fragmentation of rocks is identified on the high-velocity profile of the Chay-Yurya fault zone, both above and below the refracting boundary. The velocity values of P- and S-waves (6.0–6.1 km/s and 3.6–3.7 km/s, respectively,) and reduced values of the Vp /Vs ratio (≈1.65) concerned with intrusions of acid rocks were recorded in the southern part of the Inyali-Debin block within t he depth range of 1–1.5 km.
TYPES OF GOLD-POLYMETAL MINERALIZATION IN PRECAMBRIAN ROCKS OF THE NIMNYR TERRANE OF THE ALDAN-STANOVOY SHIELD (SOUTH OF THE NORTH ASIAN CRATON)
Authors:   Diamond and Precious Metal Geology Institute, SB RAS, Yakutsk, Russia, Kravchenko A. A. , Anisimova G. S. ,   Diamond and Precious Metal Geology Institute, SB RAS, Yakutsk, Russia, Berezkin V. I. ,   Diamond and Precious Metal Geology Institute, SB RAS, Yakutsk, Russia, Popov N. V. ,   A.A.Trofimuk Institute of Petroleum Geology and Geophysics SB RAS, Novosibirsk, Russia, Loskutov E. E. ,   Diamond and Precious Metal Geology Institute, SB RAS, Yakutsk, Russia, Zhuravlev A. I. ,   Diamond and Precious Metal Geology Institute, SB RAS, Yakutsk, Russia, Nikiforova Z. S. ,   Diamond and Precious Metal Geology Institute, SB RAS, Yakutsk, Russia
Published: August 2023

The study of material composition of the Early Precambrian continental earth crust contributes to the identification of its metallogeny. Deposits of graphite, phlogopite, and iron have been discovered in the Paleoproterozoic granulite complexes of the Aldan-Stanovoy Shield on the southern margin of the North Asian Craton, and the first gold deposit has recently been discovered. Deposits are confined to the extended boundary of the infra- and supracrustal complexes within which multistage deformations, intense metasomatosis and metamorphism of various facies are observed. Modern methods of microanalysis allow scientists to significantly supplement data on the mineral composition of deposits, characterize conditions of their formation and make a comparison. The paper considers the geological structure of granulite complexes of the central part of the Aldan-Stanovoy Shield and ore mineralization in graphite-bearing quartzites, phlogopite-containing skarns, gold-bearing crystalline shales and diaphthorites. Ore and wallrock mineral associations have been identified. The comparison was made with well-studied ore deposits near the border of the Karelian Craton. The types of mineralization and directions of comparative metallogenic analysis are discussed.
Repercussões de um Grupo de Coral Comunitário como Dispositivo de Promoção da Saúde Mental
Authors: Barros Leonardo Haddad da Costa , Pio Danielle Abdel Massih , Bettini Roseli Vernasque
Published: August 2023

Introdução: As práticas em saúde necessitam cada vez mais de um cuidado humanizado, visando à integralidade e à clínica ampliada. Para tanto, devem contemplar progressivamente a integração de diversas áreas do saber comprometidas com a mudança dos paradigmas da psiquiatria clássica. Nesse sentido, a música pode servir como um instrumento de reabilitação e um poderoso recurso em Saúde Coletiva A presente pesquisa objetiva analisar as repercussões de um coral comunitário na promoção da Saúde Mental em usuários da Rede de Atenção Psicossocial. Método: Foi realizada pesquisa qualitativa, com amostra intencional, sendo convidados os participantes usuários de um coral comunitário. Dos 12 integrantes, oito participaram das entrevistas semiestruturadas, com posterior análise de conteúdo temática. Resultados: Este artigo enfoca a categoria “Repercussões terapêuticas do coral e o papel da equipe multiprofissional”. Discussões: Discutiu-se o papel do grupo na inclusão social, aspectos cognitivos, representações psíquicas, autonomia e laços sociais. Conclusão: Houve melhora de aspectos cognitivos, autoestima, sensações de pertencimento, preenchimento, altruísmo, das relações interpessoais e o contato com a subjetividade. O convívio grupal favoreceu o protagonismo, sentimentos de motivação, utilidade, acolhimento e alegria, revelando um cuidado humanizado.
The effect of e-service quality on e-loyalty of Islamic banking customers: Does e-satisfaction act as mediator?
Authors: Rezeki M. Rafi , Majid M. Shabri Abd. , Kassim Salina H.
Published: August 2023

Purpose – This study aims to measure and analyze the mediating role of e-satisfaction on the effect of e-service quality on e-loyalty of the customers of Bank Syariah Indonesia (BSI) in Banda Aceh, Indonesia.Methodology – This study gathered the primary data by distributing questionnaires to a number of 200 BSI customers that were selected as the respondents of the study using a purposive sampling technique. A Structural Equation Modelling (SEM) technique is used to test the four proposed hypotheses.Findings – The study recorded that e-service quality has positively affected the e-satisfaction and e-loyalty of the BSI customers, respectively. E-satisfaction enjoyed by banking customers has enhanced their e-loyalty. In addition, the study documented that e-satisfaction has a partial mediating effect on the relationship between e-service quality and the BSI customers’ e-loyalty.Implications – The findings of the study suggest that to promote the customers’ e-loyalty, the BSI management should focus on improving customers’ e-satisfaction by strengthening e-service quality.Originality – This study explored the mediating role of e-satisfaction on the effect of e-service quality on e-loyalty, focusing on the users of e-banking facilities of the largest Islamic banking institution in Indonesia. Therefore, this study provides significant guidelines for the Islamic banks in maintaining and enhancing e-loyalty of customers through improving their customer satisfaction by providing a high quality of services digitally nationwide.
Improving Detection of ChatGPT-Generated Fake Science Using Real Publication Text: Introducing xFakeBibs a Supervised-Learning Network Algorithm
Authors: Hamed Ahmed Abdeen
Published: August 2023

Background: ChatGPT is becoming a new reality. Where do we go from here? Objective: to show how we can distinguish ChatGPT-generated publications from counterparts produced by scientist. Methods:By means of a new algorithm, called xFakeBibs, we show the significant difference between ChatGPT-generated fake publications and real publications. Specifically, we triggered ChatGPT to generate 100 publications that were related to Alzheimer’s disease and comorbidity. Using TF-IDF, using the real publications, we constructed a training network of bigrams comprised of 100 publications. Using 10-folds of 100 publications each, we also 10 calibrating networks to derive lower/upper bounds for classifying articles as real or fake. The final step was to test xFakeBibs against each of the ChatGPT-generated articles and predict its class. The algorithm successfully assigned the POSITIVE label for real ones and NEGATIVE for fake ones. Results: When comparing the bigrams of the training set against all the other 10 calibrating folds, we found that the similarities fluctuated between (19%-21%). On the other hand, the mere bigram similarity from the ChatGPT was only (8%). Additionally, when testing how the various bigrams generated from the calibrating 10-folds against ChatGPT we found that all 10 calibrating folds contributed (51%-70%) of new bigrams, while ChatGPT contributed only 23%, which is less than 50% of any of the other 10 calibrating folds. The final classification results using the xFakeBibs set a lower/upper bound of (21.96-24.93) number of new edges to the training mode without contributing new nodes. Using this calibration range, the algorithm predicted 98 of the 100 publications as fake, while 2 articles failed the test and were classified as real publications. Conclusions: This work provided clear evidence of how to distinguish, in bulk ChatGPT-generated fake publications from real publications. Also, we also introduced an algorithmic approach that detected fake articles with a high degree of accuracy. However, it remains challenging to detect all fake records. ChatGPT may seem to be a useful tool, but it certainly presents a threat to our authentic knowledge and real science. This work is indeed a step in the right direction to counter fake science and misinformation.
Questioning the Mechanistic-Universe Paradigm Using Chaotic Systems
Authors: Knoll Yehonatan
Published: August 2023

The following is undisputed: 1. The conceptual relation between QM, describing microscopic physics, and macroscopic irreversible physics, is as mysterious today as eighty years ago. 2. When propagating chaotic equations, arbitrarily small scales gradually become significant at arbitrarily large scales. It follows that, the long-time behavior of chaotic systems is as mysterious today as eighty years ago. Previous work by the author sheds new light on the quantum-classical riddle, suggesting that quantum weirdness is a signature of a non mechanistic ontology, viz., one not describable by some generalized state-vector plus evolution rule thereof. It is argued that neither an empirical nor a theoretical case exists against such non mechanistic ontology manifesting in certain macroscopic chaotic systems. Bell's inequality violation by separated but previously coupled such systems is one example. More radically, it is hypothesized that certain systems could fuzzily `remember their future' in the sense that, a future perturbation applied to them could be inferred from their present behavior with probability>0.5. Experiments utilizing machine learning are proposed for testing such hypotheses.
Wild Grapevine (Vitis vinifera L. Subsp. Sylvestris (C.C. Gmelin) Hegi) – Novel Species to the Israeli Flora
Authors: Rahimi Oshrit , Berger Jotham Ziffer , Shtein Ilana , Kher Mafatlal M. , Frumin Suembikya , Hübner Sariel , Weiss Ehud , Drori Elyashiv
Published: August 2023

The wild grapevine, Vitis vinifera subsp. sylvestris grows naturally throughout the northern hemisphere, including the Mediterranean region. Wild grapevines were also observed sporadically across the southern Levant and have been considered a non-native feral plant. Nevertheless, no formal characterization was conducted for wild grapevines in this region; thus, its taxonomical assignment remains elusive. Previously we have shown that the wild grapevine populations growing in northern Israel are genetically separated from the feral domesticated forms. The aim of this work was to comprehensively describe the morphological, anatomical, and ecological traits of wild grapevines naturally thriving in two distinct habitats in Israel. The dioicous nature of the wild grapevine, as well as their flower and pollen morphology, their characteristic sylvestris fruit and seed morphology, in addition to the occurrence of natural germination of seeds in close vicinity to the mother plant, all lead to our conclusion that these plants belong to Vitis vinifera subsp. Sylvestris, and should be included in the Flora Palaestina. These findings, combined with the recently-published genetic evidence for these populations significantly advance our understanding of the species' ecology and persistence under climate change.
Assessing the Impact of Data Sciences and Smart Technologies in Air Conditioning Project Management: A Delphi Method Analysis within the Construction Industry
Authors: Ali Bashar Mahmood , Akkaş Mehmet
Published: August 2023

This paper evaluates norms and assesses the level of knowledge in air conditioning project management within the construction industry. A total of 25 questions were distributed to multiple candidates, who were filtered based on pre-established inclusion and exclusion criteria. Thirty-nine candidates were ultimately approved to participate in the survey. The questions were designed to address five hypotheses, with each set of five questions corresponding to one hypothesis. The results were obtained after pre-processing the data using Matlab software. The data was pre-processed using Matlab software, and the results were analyzed using the Delphi method. The analysis revealed that only two hypotheses were approved: No matter whether there are nationalized safety rules or not, the impact of data sciences and smart technologies, including air conditioning management systems, is critical for human life in the building business.
Analysis of Observational Data of Globular Clusters within the Framework of Gaia Dr2
Authors: Turaev Sobir Jurakobilovich , Nuritdinov Salakhutdin Nasritdinovich , Rastorguev Alexey Sergeevich , Rashidov Davron Abduvali ugli
Published: August 2023

This article is a logical continuation of the work of Nuritdinov et al. (2021). We analyzed space observations of the apparent surface density of 81 globular clusters (GCs) observed by GAIA DR2 and published in de Boer et al (2019). First, we studied the features of the quality of the GC surface density data, including comparing them with the HST data. Using our 3-parameter model, previously tested on the example of HST space observations, we found the values of the stellar concentration parameter towards the center of the cluster. As a result, we found good correlations of this parameter with the physical characteristics of the GCs. We have also found the corresponding empirical formulas for this parameter.
Circulating Extracellular Vesicle-Derived microRNAs as Novel Diagnostic and Prognostic Biomarkers for Non-Viral-Related Hepatocellular Carcinoma
Authors: Boonkaew Bootsakorn , Satthawiwat Nantawat , Pinjaroen Nutcha , Chuaypen Natthaya , Tangkijvanich Pisit
Published: August 2023

Extracellular vesicle-derived microRNAs (EV-miRNAs) are promising circulating biomarkers for chronic liver disease. In this study, we explored the potential significance of plasma EV-miRNAs in non-hepatitis B-, non-hepatitis C-related HCC (NBNC-HCC). We compared plasma EV-miRNA profiles between NBNC-HCC and control groups including non-alcoholic fatty liver disease (NAFLD) and healthy controls using NanoString method. The differentially expressed EV-miRNAs were validated in another set of plasma samples by qRT-PCR. A total of 66 significantly differentially expressed EV-miRNAs between the HCC and control groups were identified in the discovery set. In the validation cohort including plasma samples of 70 NBNC-HCC, 70 NAFLD and 35 healthy controls, 5 plasma EV-miRNAs were significantly elevated in HCC, which included miR-19-3p, miR-16-5p, miR-223-3p, miR-30d-5p, and miR-451a. These miRNAs were found to participate in several cancer-related signaling pathways based on bioinformatic analysis. Among them, EV-miR-19-3p exhibited the best diagnostic performance and displayed a high sensitivity for detecting AFP-negative HCC and early-stage HCC. In multivariate analysis, high EV-miR-19-3p level was demonstrated as an independently unfavorable predictor of overall survival in patients with NBNC-HCC. In conclusion, our data have indicated for the first time that EV-miR-19-3p could serve as a novel circulating biomarker for the diagnosis and prognosis of NBNC-HCC.
Emotional Distress Caused by the Measures Taken in Assisted Reproductive Treatments during the COVID-19 Confinement in Spain
Authors: Correa Rancel Marta , Sosa Comino Elena , Leon-Larios Fatima , Suarez Hernandez Yaiza , Carballo Lorenzo Janet , Gomez-Baya Diego , Baez Quintana Delia
Published: August 2023

During the pandemic, assisted reproductive treatments suffered from major disruptions in their terms due to the restrictions imposed. The objective of this study is to evaluate the level of anxiety of women whose treatments were either suspended or delayed. Methods: Descriptive cross-sectional study conducted between April and May 2020. The State-Trait Anxiety Inventory was applied in a Spanish adapted version. The research also included social, personal, and work aspects which may be involved in the challenging situation. Results: A total of 115 patients participated in the study (73.7%). Women showed a mean in trait anxiety of 17.79 (SD = 8.80) and a mean in state anxiety of 19.95 (SD = 9.08). Neither the type of treatment nor the time of infertility are predictors of trait anxiety or state anxiety. More age pressure and more worry were associated with more trait and state anxiety (p<0.001). The most common emotional reactions to discontinuation of fertility treatments were sadness and anxiety. Conclusions: Discontinuation of fertility treatments due to confinement restrictions had a negative impact on the mental health of women who were following a process of assisted reproduction treatment, increasing their levels of emotional distress and anxiety.
Taxonomic Structure Revealed through Combining DNA Barcodes with Multi-Gene Data for Representative Taxa: Recognizing Monophyletic Species Groups within Polyommatus (Agrodiaetus) Blue Butterflies (Lepidoptera, Lycaenidae)
Authors: Lukhtanov Vladimir A. , Shapoval Nazar A. , Dantchenko Alexander V. , Eckweiler Wolfgang
Published: August 2023

The need for multi-gene analysis in evolutionary and taxonomic studies is generally accepted. However, sequencing of multiple genes is not always possible. For various reasons, short mito-chondrial DNA barcodes are the only source of molecular information for some species in many genera, although multilocus data are available for other species of the same genera. In particular, such a situation exists in the species-rich butterfly subgenus Polyommatus (Agrodiaetus). Here, we analysed partitioning of this subgenus into species groups by using three data sets. The first data set was represented by short mitochondrial DNA barcodes for all analysed samples. The second and third data sets were represented by combination of short mitochondrial DNA barcodes for a part of the taxa with longer mitochondrial sequences COI+tRNA-Leu+COII (data set 2) and with longer mitochondrial COI+tRNA-Leu+COII and nuclear 5.8S rDNA+ITS2+28S rDNA sequences (data set 3) for the remaining species. We show that DNA barcoding approach (data set 1) failed to reveal the taxonomic structure resulting in numerous polytomies in the phylogenetic tree ob-tained. Combined analysis of the mitochondrial and nuclear sequences (data sets 2 and 3) re-vealed the species groups and position within these species groups even for the taxa for which only short DNA barcodes were available.
Vapor-Gas Deposition of Polymer Coatings on Metals from Azeotropic Solutions of Organosilanes
Authors: Makarychev Yuri
Published: August 2023

The mechanism of vapor-gas deposition of vinyltrimethoxysilane (VS) and ethylene glycol (EG) from azeotropic solutions is investigated, which allows to reduce the evaporation temperature of the components of working mixtures. The need for such studies is associated with the development of a new direction in the technology of vapor-gas deposition of polymer coatings. Methods have been developed for monitoring the chemical composition of working solutions in evaporators using optical spectroscopy, which allow calculating the partial pressures of vapor phase components. Based on these studies, compositions of working solutions are proposed that allow to equalize the partial pressures of the components of working mixtures with a large difference in boiling point. A new method of vapor-gas deposition of non-volatile powder inhibitors on metals is proposed. Chemical compositions of siloxane coatings were determined using XPS and mechanisms of interaction of VS with polymerization promoters ethylene glycol and 1-hydroxy ethylidene-1,1-diphosphonic acid (HEDP) were proposed.
Back Extensor Strength as a Potential Marker of Frailty Using Propensity Score Matching and Machine Learning
Authors: Kim Taewook , Kim Gowun , Park Hee-won , Kang Eun-Kyoung , Baek Sora
Published: August 2023

This study assessed the potential of back extensor strength as an alternative marker of frailty. A total of 560 farmers were included. Computed tomography scans measured fat and muscle mass volumes at the mid-L4 vertebral level. Back extensor strength was measured in a seated posture. Multivariate linear regression analyzed the associations between back extensor strength and trunk muscle/fat compositions. The participants were divided into two groups based on back extensor strength. Propensity score matching, multivariate logistic regression, and Extreme Gradient Boosting (XGBoost) were employed to evaluate the relationship between Fried's frailty criteria and back extensor strength. Back extensor strength exhibited positive associations with abdominal muscle volume (r = 1.12) as well as back muscle volume (r = 0.89) (p < 0.05). Lower back extensor strength was linked to more frail status, such as reduced grip strength, walking speed, and fre-quent self-reported exhaustion. Multivariate logistic regression indicated a significant association between lower back extensor strength and higher Fried frailty score (OR, 0.990; p<0.05). XGBoost analysis identified back extensor strength as the most important predictor (gain = 0.502) for frailty, surpassing the significance of age (gain = 0.325). These findings suggested the potential of back extensor strength as an alternative frailty marker.
Using Deep Neural Network Methods for Forecasting Energy Productivity Based on Comparison of Simulation and DNN Results for Central Poland – Swietokrzyskie Voivodeship
Authors: Pikus Michał , Wąs Jarosław
Published: August 2023

Forecasting electricity demand is of utmost importance for ensuring the stability of the entire energy sector. However, predicting the future electricity demand and its value poses a formidable challenge due to the intricate nature of the processes influenced by renewable energy sources. Within this piece, we have meticulously explored the efficacy of fundamental deep-learning models designed for electricity forecasting. Among the deep learning models, we have innovatively crafted recursive neural networks (RNNs) predominantly based on LSTM and combined architectures. The data-set employed was procured from a SolarEdge designer. The data-set encompasses daily records spanning the past year, encompassing an exhaustive collection of parameters extracted from solar farm (based on location in Central Europe (Poland Swietokrzyskie Voivodeship)). The experimental findings unequivocally demonstrated the exceptional superiority of the LSTM models over other counterparts concerning forecasting accuracy. Consequently, we compared multilayer DNN architectures with results provided by the simulator.
Possible New Histological Prognostic Index for Large B-Cell Lymphoma
Authors: Nitta Hideaki , Takizawa Haruko , Mitsumori Toru , Iizuka-Honma Hiroko , Araki Yoshihiko , Fujishiro Maki , Tomita Shigeki , Kishikawa Satsuki , Hashizume Akane , Sawada Tomohiro , Okubo Mitsuo , Sekiguchi Yasunobu , Ando Miki , Noguchi Masaaki
Published: August 2023

We conducted a retrospective analysis of the immunohistochemical (IHC) staining GRP94, an ER stress protein on large B-cell lymphoma (LBCL) cells, intracellular p53, and 15 factors involved in the metabolism of CHOP regimen :AKR1C3 (HO-metabolism), CYP3A4 (CHOP-metabolism) and HO efflux pumps (MDR1, MRP1). The study subjects were 42 patients with LBCL at our hospital. IHC staining using antibodies against the 17 factors. The odds ratios by logistic regression analysis using a dichotomous variable of CR, non-CR/relapse were statistically significant: for MDR1, MRP1, and AKR1C3. The overall survival (OS) after R-CHOP was compared by the log-rank test. The four groups showed that Very good (5-year OS, 100%) consisted of 4 patients showed negative IHC staining for both GRP94 and CYP3A4. Very poor (1-year OS, 0%), consisted of 3 patients who showed positive results of IHC for both GRP94 and CYP3A4. The remaining 35 patients comprised two subgroups: Good (5-year OS 60-80%.): 15 patients who showed negative staining for both MDR1 and AKR1C3, Poor: 5-year OS, 10-20%) :20 patients who showed positive staining for either MDR, AKR1C3,,MRP1 or p53. The Histological Prognostic Index (HPI) (The four groups: Very poor, Poor, Good, and Very pood) is a breakthrough method for stratifying patients based on factors involved in the development of treatment resistance.
Estimating model for COVID-19 Infected Cases and Deaths in Tamil Nadu State
Authors: Arunachalam Rajarathinam
Published: August 2023

The impacts of COVID-19 (Novel Coronavirus) epidemic cannot have been more severe, with the globe experiencing both economic and health crises. This study examines the trends and correlations in number of COVID-19-related deaths and number of COVID-19-infected patients in all 37 regions of Tamil Nadu state, India, in the month of August 2020 on the basis of panel regression model,
Mapping Quantitative Trait Locus (QTLs) for Hundred Pod and Seed Weight under Seven Environments in a RIL Cultivated Peanut (Arachis hypogaea L.) Population
Authors: Miao Penghui , Meng Xinhao , Li Zeren , Sun Sainan , Chen Charles Y , Yang Xinlei
Published: August 2023

Cultivated Peanut (Arachis hypogaea L.) is an important oil and cash crop in worldwide. Hundred pod and seed weight are important components for peanut yield. In order to dissect the genetic control of hundred pod weight (HPW) and hundred seed weight (HSW), a RIL population containing 188 individuals was developed from a cross between Jihua 5 (JH5, large pod and seed size) and M130 (small pod and seed size). An integrated genetic linkage map was constructed by using SSR, AhTE, SRAP, TRAP and SNP markers. The map contained 3,130 genetic markers which were assigned to 20 chromosomes and covered 1,998.95 cM with an average distance 0.64 cM. Based on the genetic map, a total of 31 QTLs for HPW and HSW were identified on 7 chromosomes, explaining 3.7-10.8% of the phenotypic variation by each QTL. Among these, seven QTLs were detected under more than two environments, two major QTLs were found on B04 and B08, respectively. A QTL hotspot containing seven QTLs was detected on chromosome A08 spanning a 2.74 cM genetic interval with 0.36 Mb physical map which included 18 candidate genes. Among these, Arahy.D52S1Z, Arahy.IBM9RL, Arahy.W18Y25, Arahy.CPLC2W and Arahy.14EF4H may be involved in regulating peanut pod and seed weight. These results may help further analysis of genetic mechanisms for pod and seed size in cultivated peanut.
Development of a Mouse-Adapted Reporter SARS-CoV-2 as a Tool for Two-Photon In Vivo Imaging
Authors: Ueki Hiroshi , Kiso Maki , Furusawa Yuri , Iida Shun , Yamayoshi Seiya , Nakajima Noriko , Imai Masaki , Suzuki Tadaki , Kawaoka Yoshihiro
Published: August 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) often causes severe viral pneumonia, especially among older individuals and those with underlying health conditions. The C57BL/6 mouse is widely used to develop mouse models of obesity, diabetes, hypertension, and immune disorders, conditions that are associated with increased risk of severe COVID-19. Although many studies using these mouse models have examined the pathogenicity of SARS-CoV-2, COVID-19 pathogenesis remains poorly understood. In vivo imaging analysis using two-photon excitation microscopy is useful for elucidating the pathology of COVID-19, providing pathological insights that are not available from conventional histological analysis. However, there is no reporter SARS-CoV-2 that demonstrates pathogenicity in C57BL/6 mice and emits sufficient light intensity for two-photon in vivo imaging. Here, we generated SARS-CoV-2 expressing the fluorescent protein Venus to facilitate in vivo pathological studies using C57BL/6 mouse models. We generated a mouse-adapted strain of SARS-CoV-2, by performing sequential lung-to-lung passages in BALB/c mice, followed by in C57BL/6 mice. We observed that the C57BL/6-adapted SARS-CoV-2 (named MASCV2-p25) replicated efficiently in the lungs of C57BL/6 mice, causing fatal pneumonia. Histopathologic analysis revealed severe inflammation and infiltration of immune cells in the lungs of MASCV2-p25-infected C57BL/6J mice, not unlike that observed in COVID-19 patients with severe pneumonia. Subsequently, we generated a mouse-adapted reporter SARS-CoV-2 (named MASCV-Venus-p9) by inserting the fluorescent gene Venus into MASCV2-p25, and sequential lung-to-lung passages in C57BL/6 mice. C57BL/6 mice infected with MASCV2-Venus-p9 exhibited severe pneumonia similar to that induced by MASCV2-p25. In addition, two-photon excitation microscopy of the lungs of the infected C57BL/6J mice showed that the infected cells emitted sufficient levels of fluorescence for easy observation. These findings suggest that MASCV2-Venus-p9 will be useful for two photon in vivo imaging studies of the pathogenesis of severe COVID-19 and for the development of therapeutic agents for severe pneumonia.
Optimizing Manufacturing Cycles for Advantage Production: Application in Shipyards Traditional industry
Authors: JEBBOR Ikhlef , BENMAMOUN Zoubida , HACHIMI Hanaa
Published: August 2023

This article explores the important role of traditional shipyards in the global maritime industry, covering aspects of construction, repair, and maintenance. With the advent of faster manufacturing techniques, traditional shipyards face important challenges such as planning errors, coordination problems, delivery delays, and underutilization of technology, which results in high costs, reduced productivity, and prolonged projects. The application of Manufacturing Cycle Efficiency (MCE) emerged as an important solution to significantly increase production efficiency. MCE empowers shipyards to deal effectively with waste, bottlenecks, and disruptions, thereby increasing performance, competitiveness, and profitability. Using a comprehensive approach that uses both qualitative and quantitative methods, including field surveys, and in-depth interviews in the traditional shipyards industry, this research identifies Non-Value-Added (NVA) processes, conducts process mapping, and calculates MCE. The findings reported in this article underscore the significant wastage in the production process, indicating an urgent need for improvement, given the current average MCE value of 67.08%, indicating considerable room for improvement. This article provides innovative perspectives on optimizing the traditional shipyards industry through production cycle efficiencies while offering actionable recommendations. Key focus areas include integrating management systems, adopting advanced technologies, and implementing sustainable strategies to improve MCE, especially by reducing non-value-added time wastage, such as inspection and storage. By implementing strategies that optimize production, minimize waste, and overcome the challenges of global competition, this research contributes to improving MCE. In conclusion, this study is an invaluable guide for industry stakeholders, enabling them to enhance their competitiveness and adapt effectively to a dynamic business environment.
Broadening the Substrate Specificity of Cellobiose Phosphorylase from Clostridium thermocellum for Improved Transformation of Cellodextrin to Starch
Authors: Zhang Yuanyuan , Li Yapeng , Lin Hui , Mao Guotao , Long Xiang , Liu Xinyu , Chen Hongge
Published: August 2023

Cellobiose phosphorylase (CBP) catalyzes the reversible phosphorolysis of cellobiose into α-glucose 1-phosphate and glucose. When it was used in transforming cellulose to amylose (PNAS, 110: 7182-7187, 2013) as well as in constructing a yeast with the ability to phosphorolytically use cellodextrin to produce ethanol, a CBP with a broadened substrate specificity would be more desirable. Based on the structure differences in the catalytic loops of CBP and cellodextrin phosphorylase from Clostridium thermocellum (named CtCBP and CtCDP, respectively), CtCBP was mutated. A single-site mutant S497G was identified to have a 5.7-fold higher catalytic efficiency with cellotriose as a substrate in phosphorolytic reaction direction compared to wild type, without any loss of catalytic efficiency on its natural substrate cellobiose. When S497G variant was used in the transformation of mixed cellodextrin (cellobiose + cellotriose) to amylose, a significant increase in amylose yield was achieved compared to that of wild type CtCBP. Structure change in the substrate binding pocket of S497G variant accounted for its capacity to accept longer cellodextrins than cellobiose. Taken together, S497G variant of CtCBP was confirmed to acquire a promising feature favorable to those application scenarios involving cellodextrin’s phosphorolysis.
PELATIHAN PEMANFAATAN PHET INTERACTIVE SIMULATIONS SEBAGAI SARANA PRAKTIKUM DALAM PEMBELAJARAN PADA MASA PANDEMI COVID-19 BAGI GURU MGMP IPA MTS KABUPATEN SLEMAN
Authors: Wibowo Widodo Setiyo , Allesius Maryanto  , Sabar Nurohman  , Laifa Rahmawati
Published: August 2023

Practicum activities cannot be separated from science learning. However, in online learning, this is not easy to do. Therefore, this community service activity aims to train the ability of science teachers to use PhET Interactive Simulations as a practical tool in learning science in the era of learning from home (BDR) due to the Covid-19 pandemic. The subjects were the science teachers of MTs/ junior high school in Sleman Regency Special Distric of Yogyakarta. This activity was carried out virtually using video conferencing and e-learning media, and was attended by 27 participants. Generally, the stages of the program include preparation, implementation and evaluation. Evaluation data were collected using questionnaires and product assessment sheets and analyzed using descriptive statistics. The results shows that the trainees are able to use PhET Interactive Simulations in conducting science lab work virtually. It can be seen from the increase in knowledge about the basics of PhET, the ability to download and install PhET, operate PhET, and compile worksheets to apply PhET.The results hopefully help science teacher in improving science learning quality in study from home program.

 

Abstrak

Kegiatan praktikum tidak dapat dilepaskan dalam pembelajaran IPA. Akan tetapi dalam pembelajaran secara daring, hal ini tidak mudah untuk dilakukan. Oleh karenanya, kegiatan pengabdian ini bertujuan untuk melatih kemampuan guru-guru IPA dalam menggunakan PhET Interactive Simulations sebagai sarana praktikum dalam pembelajaran IPA di era belajar dari rumah (BDR) akibat pandemi Covid-19. Khalayak sasaran dalam kegiatan ini adalah guru-guru IPA anggota Musyawarah Guru Mata Pelajaran (MGMP) IPA MTs Kabupaten Sleman DIY. Kegiatan ini dilaksanakan secara virtual dengan media video conferencing dan e-learning, serta diikuti oleh 27 guru. Tahapan-tahapan kegiatan ini meliputi persiapan, pelaksanaan, dan evaluasi. Data evaluasi dikumpulkan dengan angket dan lembar penilaian produk dan dianalisis secara statistik deskriptif. Berdasarkan kegiatan yang telah dilakukan, diperoleh hasil bahwa guru-guru IPA telah mampu menggunakan PhET Interactive Simulations sebagai sarana praktikum dalam pembelajaran IPA secara daring. Hal ini terlihat dari peningkatan pengetahuan tentang dasar-dasar PhET, kemampuan mendownload dan menginstall PhET, mengoperasikan PhET, serta menyusun worksheets untuk mengaplikasikan PhET. Hasil pelatihan diharapkan dapat membantu para guru dalam meningkatkan kualitas pembelajaran IPA di era BDR.
LESÕES BUCOMAXILOFACIAIS DECORRENTES DE VIOLÊNCIA DOMÉSTICA CONTRA MULHERES: UMA REVISÃO INTEGRATIVA.
Authors: Nunes Janaína Gleice Martins , Ribeiro Enya Laissah Freire , Santos Misael Iron Guimarães , Veloso Kátia Maria Martins
Published: August 2023

A violência doméstica contra a mulher tem sido considerada um grave problema de saúde pública no Brasil e em vários países do mundo. O cirurgião-dentista atua no tratamento da enfermidade causada por agressões, e também possui obrigação ética-legal no dever de conscientizar e registrar casos onde suas pacientes tenham sido vítimas. O presente estudo analisou os principais tipos de lesões bucomaxilofaciais decorrentes de violência doméstica contra mulheres, e suas causas, traçando um perfil de agressores e vítimas contribuindo para que o cirurgião-dentista tenha conhecimento do tema atuando na prevenção, acolhimento, atendimento e encaminhamento das vítimas. Trata-se de uma revisão integrativa da literatura com buscas realizadas nas bases de dados Pubmed, Bireme, LILACS, SciELO, utilizando descritores e seus sinônimos na língua portuguesa e língua inglesa, incluindo estudos publicados entre 2011 e 2021 para a análise dos resultados. Observou-se que as vítimas de violência doméstica em sua maioria são mulheres jovens, que convivem ou conviveram com os agressores, violentadas com agressões que lesam estruturas maxilomandibulares e isso decorre da superexposição anatômica dessa região a traumas que incluem lesões teciduais e ósseas, cabendo ao cirurgião-dentista estar atento não só ao reconhecimento dos casos, mas corroborar no tratamento das vítimas e no enfrentamento desse tipo de violência em nossa sociedade.
CONHECIMENTO, PRÁTICA E OPINIÃO DE ODONTOLEGISTAS SOBRE A MARCAÇÃO IDENTIFICADORA DE PRÓTESES DENTÁRIAS
Authors: Campos Edine Maria de Medeiros , Pascoal Ana Luísa de Barros , Emiliano Gustavo Barbalho Guedes , Duarte Antônio Ricardo Calazans
Published: August 2023

Introdução: A marcação ou identificação de próteses dentárias é feita através da incorporação de etiquetas metálicas, não metálicas ou outras no material da prótese, ou ainda pela marcação da superfície. Apesar de ser recomendada por organizações governamentais e forenses, ela não é amplamente empregada no Brasil. Objetivo: Analisar o nível de conhecimento e descrever a opinião e experiência de odontolegistas brasileiros com a marcação protética. Material e métodos: Foi aplicado um questionário semiaberto a odontolegistas sobre o conhecimento, opinião e prática com a identificação protética. A análise estatística foi feita no software Microsoft Excel. Resultados: Foram obtidas respostas de 43 especialistas das cinco regiões do Brasil. 76% afirmaram conhecer o termo, mas apenas 14% relataram possuir experiência prática e 95% julga ser importante. Dos que já realizaram a prática e a descreveram, todos a utilizaram em situações forenses com cadáveres. Os maiores obstáculos apontados para a implementação foram a falta de conhecimento, a falta de diretrizes oficiais e o custo. Sobre a necessidade de implementar a marcação na prática clínica, 77% responderam que é necessária em todos os casos, mas com relação à obrigatoriedade de implementá-la, 56% declararam que deve ser recomendada, mas não obrigatória e 39%, que deve ser obrigatória. Conclusão: O conhecimento dos odontolegistas sobre a marcação de próteses é considerável e a maioria julga importante, no entanto, poucos tiveram contato com a prática e nenhum a realiza na clínica. Evidencia-se a necessidade da elaboração de diretrizes ou recomendações por entidades odontológicas, ressaltando a importância sócio legal da prática
ESTRATÉGIAS DE PUBLICIDADE POR ÁREAS DE ATUAÇÃO ODONTOLÓGICA NA REDE SOCIAL INSTAGRAM®
Authors: Barbalho Guedes Emiliano Gustavo , Araújo de Oliveira Camila Cristine , Amaro Vieira Pereira Marcelo Augusto , Costa de Araújo Souza Georgia
Published: August 2023

Introdução: O Instagram® é a quarta rede social mais popular em todo o mundo para criar e compartilhar conteúdos editáveis e a mais utilizada para buscar serviços de saúde. Considerando que as redes sociais estão cada vez mais interligadas com a Odontologia e o mercado de trabalho, o objetivo dessa pesquisa foi classificar as estratégias de publicidade utilizadas na rede social Instagram® pelos cirurgiões-dentistas nas áreas de atuação. Material e métodos: Trata-se de um estudo quantitativo, transversal e retrospectivo. Os dados foram prospectados a partir de hashtags relacionadas à Odontologia, em dois períodos diferentes (janeiro/2022) e (março/2022). As postagens foram identificadas por áreas odontológicas e as imagens e/ou legendas classificadas de acordo com a estratégia de publicidade utilizada e realizou-se uma análise descritiva. Resultados: Em relação à imagem, de 1.111 posts, 87,1% (n=965) utilizaram apenas uma estratégia de publicidade e 12,9% de duas a cinco estratégias na mesma postagem. Quanto à legenda, de 529 publicações, 48,4% (n=256) corresponderam a uma estratégia e 51,6% (n=273) de duas até quatro simultaneamente. As estratégias mais frequentes na imagem foram ‘lembranças de serviços odontológicos’ (29,5%) e ‘antes e depois’ (16,1%) e, na legenda ‘explicativo’ (40,1%) e ‘lembranças de serviços odontológicos’ (31,7%). Conclusão: Áreas que valorizam o resultado estético alcançado, como odontologia integrada, harmonização orofacial, dentística, periodontia, ortodontia e prótese exploram mais o ‘antes e depois’, enquanto que outras áreas relacionadas ao tratamento e prevenção de doenças estão mais relacionadas a ‘lembranças de serviços odontológicos’
PERCEPÇÃO DOS ESTUDANTES DE ODONTOLOGIA SOBRE O ABUSO INFANTIL NA CIDADE DE FLORIANÓPOLIS (SC), BRASIL
Authors: Hillesheim Leonardo , Colussi Cláudia Flemming , Barros Beatriz Álvares Cabral de
Published: August 2023

O abuso infantil é, ainda, um dos grandes problemas de saúde pública no Brasil e no mundo, sendo que em 2020, houve o registro de mais de 75 mil notificações no Brasil. É de suma importância que os profissionais de saúde, sobretudo, cirurgiões-dentistas, estejam capacitados para fazer a identificação e notificação de suspeitas e casos de abuso infantil. Esta pesquisa analisou a percepção dos estudantes de odontologia da Universidade Federal de Santa Catarina (UFSC) sobre o abuso infantil e instrução destes para a realização da notificação compulsória às autoridades na cidade de Florianópolis. Foi aplicado um questionário eletrônico com dezesseis questões abertas e fechadas previamente estabelecidas pelos autores tendo como base estudos anteriores sobre o tema, com uma amostra não-probabilística composta por 69 participantes de todas as fases do curso de graduação em odontologia da UFSC por meio de um estudo transversal. Mais de 97% (n=67) dos entrevistados afirmaram saber o que é abuso infantil, no entanto, aproximadamente 80% (n=54) afirmaram não saber proceder frente a um caso e cerca de 90% (n=62) afirmaram não conhecer a legislação sobre notificação compulsória e 80% (n=57) afirmaram haver interesse em buscar informações sobre o tema. É imprescindível que estudantes de odontologia e cirurgiões-dentistas sejam capazes não só identificar casos de abuso infantil, mas como proceder e mitigar o ciclo de violência no qual esta criança está inserida.
ANALYSIS OF THE ANTHROPOMETRIC MEASUREMENTS OF THE SMILE USING 3D STEREOPHOTOGRAMMETRY
Authors: Moreira Isabela dos Santos , Da Silva Mirela Cristina , Mazzi-Chaves Jardel Francisco , Valencise Magri Laís
Published: August 2023

3D stereophotogrammetry makes the analysis of facial soft tissues possible, and has the potential to contribute to human identification processes. Nowadays, the images available through social networks are composed of a significant amount of smile photos, making techniques such as 3D stereophotogrammetry relevant. The objective of the present study was to quantitatively analyze the anthropometric measurements of the smile through 3D stereophotogrammetry, including area, angular, and linear measurements. Anatomical landmarks were used to make possible the area, angular, and linear measurements. The sample consisted of 27 volunteers, 13 female and 14 male, both in the 19-25 age group, resulting in a mean age of 22.3±1.9 and 23.3±1.5, respectively. The anatomical landmarks were marked on the face of the volunteers using a black eyeliner, and the photographs were taken using the 3D stereophotogrammetry technique (Vectra H1, Canfield, NY, USA), being 3 photographs with a spontaneous smile and 3 at rest, right lateral, left lateral and frontal of each. Among the results of the comparison between genders and the photo/smile relation of the statistical analysis, variables such as the mentolabial angle and the vermilion height of the upper lip showed significant p-values of 0.046 and 0.014, respectively. It can be concluded that anthropometric measurements of three-dimensional smile images can be performed with the use of 3D stereophotogrammetry, with the purpose of contributing to facial identification methods.