bluuebunny/crossref_metadata_2025 huggingface dataset:
Significance of N-terminal pro-B-type natriuretic peptide levels in lung cancer
Authors: İnan Sinem , Bilaçeroğlu Semra , Uludağ Artun Burcu
Published: January 2025

High blood levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) have been shown in various malignancies. In lung cancer, the importance of NT-proBNP is not clear. In this study, we aimed to investigate the significance of the correlation of NT-proBNP levels in lung cancer with tumor stage, tumor diameter, histopathology, and specific sites of mediastinal metastasis: lymphadenopathy; pericardial, cardiac, major vessel, other mediastinal organ or lymphatic involvement/invasion. A total of 105 lung cancer and 120 control patients (chronic obstructive lung disease, interstitial lung disease, pulmonary thromboembolism, and pneumonia; 30/subgroup) with measured NT-proBNP levels were included retrospectively. Demographics, comorbidities, and echocardiographic findings in all patients, as well as histologic subtype, diameter, stage, and radiologic and/or pathologic mediastinal involvement/invasion of the tumor to the mediastinum in patients with lung cancer, were studied with regards to blood NT-proBNP levels. When lung cancer and control groups were compared globally or as subgroups with comorbidities, NT-proBNP levels did not show meaningful differences. However, NT-proBNP levels were determined to be 249 pg/mL and 88 pg/mL in lung cancer (n=68) and control subgroups (n=58) without comorbidities, respectively (p=0.001). Among lung cancer patients without comorbidities and those with cardiac, pericardial, major vascular, or other mediastinal involvement/invasion (lymphadenopathy, lymphatic, or other organ invasion) (n=27), the NT-proBNP level was 303 pg/mL, whereas it was 166 pg/mL in those without these mediastinal invasions (n=41) (p=0.031). There is a need for much larger, randomized studies to obtain evidence for the potential role of NT-proBNP as a helpful diagnostic biomarker for lung cancer. Clinical suspicion of malignancy may be posed if high NT-proBNP levels cannot be explained by all other risk factors and disorders or diseases. Furthermore, pericardial, cardiac, major vessel, or other mediastinal invasion/involvement should be sought when high NT-proBNP levels are determined in lung cancer patients without any comorbidities or risk factors for high NT-proBNP levels.
Prostate cancer screening knowledge and attitude among men over 50 at a referral Hospital in Oshana region, Namibia
Authors: Kashihakumwa Lonia , Ashipala Daniel O. , Jafaru Yahaya
Published: January 2025

Background: Prostate cancer is the third most common cancer in men and fourth in causing cancer-related deaths in both men and women in Africa.Aim: The aim of this study was to assess knowledge and attitudes about prostate cancer screening among men over 50 years.Setting: The study setting is Intermediate Hospital Oshakati.Methods: A quantitative cross-sectional design was adopted. Census sampling was employed, and the data were collected through the use of a structured, self-administered questionnaire. Data were analysed with the aid of the Statistical Package for the Social Sciences (SPSS) version 26.0 using frequencies and percentages, and Chi-square test of association.Results: Majority of the respondents were knowledgeable about prostate cancer except in questionnaire items 3, 12 and 13 in which they (71.8%, 82.4% and 94.7%, respectively) were not knowledgeable. In all the items of the questionnaire, majority of the respondents had positive attitudes towards prostate cancer screening. The percentages of the positive attitude range from 80% to 95% across all the items. There is no significant association between the respondents’ prostate cancer screening knowledge and all the respondents’ characteristics (age, level of education, marital status and religion), p  0.05, respectively. There is no significant association between respondents’ prostate cancer screening attitude and all the respondents’ characteristics, p  0.05, respectively.Conclusion: The survey respondents were knowledgeable about prostate cancer screening, except when it comes to the different methods of diagnosing prostate cancer, what happens to the prostate gland in prostate cancer and who should be screened for prostate cancer.Contribution: The results from this study can be used by the Ministry of Health and Social Services and its stakeholders to create a baseline data which help to develop appropriate preventative measures and awareness programmes. Furthermore, this study can be used to identify possible reasons for the late reporting of men for PCa screening and aid to inform the public on the need for early-seeking behaviour through screening.
Neurocognitive function and health-related quality of life among glioblastoma patients: A prospective study
Authors: Baba Mohamed A , Kharbach Ahmed , Lmejjati Mohamed , Adali Nawal
Published: January 2025

Background: Glioblastomas are aggressive brain tumours that significantly impact patients’ functional and psychological well-being, making the evaluation of health-related quality of life (HRQoL) essential.Aim: This study aims to assess the quality of life (QoL) and neurocognitive status of glioblastoma patients in Morocco.Setting: Patients were recruited from two renowned oncology centres in Morocco.Methods: Patients receiving care at two renowned oncology centres were enrolled between April 2021 and January 2024. The QLQ-C30 and QLQ-BN20 scales were used to assess QoL, while neurocognitive function was evaluated using the Mini-Mental State Examination (MMSE) test. Data normality were checked using the Shapiro-Wilk test, and non-parametric methods were used to compare scores. Variables such as age, tumour laterality, residence, and educational status were examined for their association with overall QoL. Both univariate linear regression and multivariate regression analyses were conducted. Statistical analyses were performed using the JAMOVI software.Results: The study enrolled 106 patients, with a median age of 56.7 years. Among them, 66% were male, while 34% were female. Multiple linear regression showed that age (B: –15.46; 95% CI: –24.15 to –6.77; p  0.001), education level (B: –9.36; 95% CI: 0.84 to 17.88; p = 0.032), distance from hospital (B: –9.85; 95% CI: –18.34 to –1.36; p = 0.023), and tumour laterality (B= –12.36; 95% CI: –20.65 to –4.06; p = 0.004) were significantly associated with overall QoL at 3 months follow-up.Conclusion: The results indicate a decline in HRQoL during follow-up among glioblastoma patients. Advancing age, tumour location on the left side, education level, and proximity to the hospital significantly influence the overall QoL.Contribution: This study highlights the critical factors impacting HRQoL in glioblastoma patients in Morocco, providing insights for improving patient care.
Age of detection of congenital hearing loss in South Africa: A systematic review
Authors: Phanguphangu Mukovhe , Kgare Khomotjo , Ross Andrew J.
Published: January 2025

Background: Newborn hearing screening is the most important step towards early intervention of congenital or early-onset hearing loss (HL) and has the potential to optimise patient outcomes. Yet, literature on the age of identification of this HL in South Africa (SA) is sparse.Aim: To determine the age of identification of congenital HL from published studies in SA.Setting: The study was conducted in SA.Methods: This was a systematic review conducted during April 2024 – June 2024 across the following databases: PubMed, EBSCO, Web of Science and Scopus. A random effects (RE) model meta-analysis was conducted using STATA version 18. Statistical tests conducted include meta-summary statistics and RE meta-analysis.Results: Ten studies, with a total of 1501 children, were included in this review. The computed Q-test of homogeneity was 5870.97 and the pooled mean age of identification was 30 months (95% confidence intervals [CI]: 19.3–41.3).Conclusion: These findings show that congenital or early-onset HL in SA is identified later than the national and international standards, that is, 1 month of age. These findings are important for future research, priority setting and implementation of strategies to reduce the burden and impact of HL. Future research investigating the barriers to early detection of HL in SA is recommended. Furthermore, the implementation of evidence-based interventions to lower the age of identification of congenital HL to enable its early detection and intervention in this age group is recommended.Contribution: This study highlights the need to strengthen preventative programmes for paediatric HL in SA.
Is differential cleaning needed for SARS-CoV-2 beyond standard procedures? A systematic review
Authors: Okomo Uduak , Aquaisua Ememobong N. , Asemota Osamagbe , Ndukwu Deborah , Egbung Josephine E. , Esu Ekpereonne B. , Oduwole Olabisi A. , Ehiri John E.
Published: January 2025

Background: There is a substantial risk of indirect transmission of SARS-CoV-2 from contaminated surfaces and objects in healthcare settings.Aim: To evaluate the effectiveness of enhanced cleaning protocols for high-touch surfaces during COVID-19, focusing on cleaning products, concentrations, contact time, and recommended frequency.Setting: We focused on research conducted in healthcare settings or where samples were obtained from healthcare environments.Method: We assessed studies that compared different cleaning, disinfection, sterilisation, or decontamination procedures and cleaning frequency with standard or routine procedures. We prioritised randomised trials, non-randomised controlled trials, controlled before-and-after studies, and interrupted time series analyses carried out between 01 January 2020 and 31 August 2022.Results: Three studies met our criteria from 2139 references searched. These studies, which took place in Iran, China and the United States, found that routine terminal cleaning and enhanced terminal cleaning with different cleaning enhancements significantly reduced SARS-CoV-2 surface contamination. One of the studies tested residual SARS-CoV-2 levels after routine and terminal cleaning with varying strengths of disinfectant and evaluated the efficacy of two common types of disinfectants in inactivating SARS-CoV-2 on inanimate surfaces in different hospital wards.Conclusion: Limited evidence supports cleaning strategies that can reduce the transmission of SARS-CoV-2 from surfaces in healthcare settings. Combining various cleaning methods and using multiple disinfectants can effectively reduce surface contamination.Contribution: Randomised controlled trials are crucial for evaluating cleaning effectiveness. They must outline cleaning protocols, detailing frequency, product concentration and volume, application methods, soil and surface types, and environmental conditions, to provide strong evidence.
‘Gender affirming healthcare’ is not what the family physician needs to know
Authors: Giddy Janet , Donkin Allan , Rodseth Reitze
Published: January 2025

No abstract available.
Diagnostic performance of contrast-enhanced T2-FLAIR MRI in the detection of meningitis
Authors: P. Sanjay , Manohar Vittal , Balol Sushmita , Naik M.B. Yashwanth
Published: January 2025

Background: The contrast-enhanced T2-FLAIR (CE-T2-FLAIR) sequence on MRI, through the suppression of CSF and vascular signals, can detect subtle meningeal enhancement in meningitis that may not be appreciable on the routinely used contrast-enhanced T1W (CE-T1W) sequence.Objectives: To assess CE-T2-FLAIR compared to CE-T1W in the diagnosis of meningitis, using CSF analysis as the gold standard, using both qualitative and quantitative approaches for assessment.Method: A retrospective study was conducted on 53 patients with clinically suspected meningitis referred for brain MRI. Twenty-seven patients, positive for meningitis on CSF analysis, were classified as the case group; the remaining patients were designated as controls. The pre-contrast, CE-T1W and CE-T2-FLAIR images were assessed and analysed, qualitatively for the detection of abnormal meningeal enhancement, and quantitatively by measuring single pixel signal intensities (SPSI) over the meninges and vessels.Results: Contrast-enhanced T2-FLAIR demonstrated significantly higher sensitivity (92.59% vs. 57.69%), negative predictive value (92.59% vs. 70.27%) and diagnostic accuracy (94.34% vs. 78.85%) compared to CE-T1W. Additionally, CE-T2-FLAIR showed significantly greater meningeal SPSI and enhancement than CE-T1W.Conclusion: Contrast-enhanced T2-FLAIR is better at detecting abnormal meningeal enhancement in meningitis than CE-T1W, because of significantly greater signal intensity and enhancement of the meninges compared to vessels.Contribution: This study reiterates the usefulness of CE-T2-FLAIR as an additional sequence for the detection of abnormal meningeal enhancement in cases of meningitis as confirmed both qualitatively and quantitatively.
[18F]FDG- PET/CT in Staging and Restaging of Fetal Type Adenocarcinoma of the Lung: A Case Report and a Review of the Literature
Authors: Bellini Pietro , Dondi Francesco , Viganò Gian Luca , Bertagna Francesco
Published: January 2025

Fetal type adenocarcinoma (FTA) is a rare malignant tumor of the lung that histologically resembles an embryonic lung. Due to its rarity, no studies had investigated the possible role of the 18F-fluorodeoxyglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) in the initial assessment and/or in the restaging of the disease yet. We present a case of a male patient with tongue carcinoma and incidental findings of well-differentiated FTA at [18F]FDG PET/CT. The patient was treated by specific therapy and also performed a subsequent [18F]FDG PET/CT scan that showed a significant reduction of the uptake on lung lesion. This case highlights the potential role and usefulness of PET imaging for staging and posttherapeutic restaging of well-differentiated FTA. The review of the available literature underlined the rarity of the disease since only seven reports were present. Anyway, a possible role of the [18F]FDG PET/CT in the staging of FTA is conceivable.
FDG PET Scan in Cutaneous Rosai–Dorfman–Destombes Disease
Authors: Solav Shrikant Vasantrao , Vora Chakor , Jagtap Rajlaxmi , Savale Shailendra , Shaikh Ishtiyaq , Solav Aman
Published: January 2025

Rosai–Dorfman–Destombes (RDD) disease is also called as sinus histiocytosis and is characterized by enlarged lymph nodes and previously called as non-Langerhans cell histiocytosis. Based on pathologic, molecular, and genetic features, RDD disease has been classified into sporadic noncutaneous (classical nodal, extranodal, neoplasia associated, and autoimmune associated), familial (H syndrome, autoimmune lymphoproliferative syndrome related, and familial NOS), and cutaneous subtypes. Cutaneous RDD disease is not associated with lymphadenopathy or visceral organ involvement. The disease is usually localized and has relatively better long-term prognosis. Presented here is a case of indurated plaque-like skin lesions over the abdomen. 18F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography scan revealed FDG avid cutaneous–subcutaneous soft-tissue lesions. Histology confirmed the diagnosis of cutaneous RDD disease.
[18F]FDG- PET/CT Imaging Spectrum of the Most Prevalent Adrenal Lesions
Authors: Singh Man Mohan , Pareek Pravin Suresh , Kakkar Lavish , Thakur Priyamedha Bose , Deswal Satyawati
Published: January 2025

Detection of adrenal lesions either incidentally, or in symptomatic cases and/or during staging/restaging of oncological cases, it is very crucial to know the adrenal lesion is benign or malignant. Fluorodeoxyglucose positron emission tomography–computed tomography (FDG PET/CT) helps in this comprehensive evaluating process. Here, we present the most frequently facing adrenal lesions in routine oncological PET/CT scans. The aim of this presentation is to know the FDG uptake spectrum of various adrenal lesions on PET/CT scan so that increase the diagnostic accuracy and spectrum of differential diagnosis.
Atypical Appearance on Radioiodine Scintigraphy Due to Achalasia Cardia – A Potential Diagnostic Pitfall
Authors: Chandekar Kunal Ramesh , Damle Nishikant Avinash , Bal Chandrasekhar
Published: January 2025

We present the case of a 36-year-old woman with papillary thyroid cancer (PTC) who had undergone thyroidectomy and nodal dissection. In addition to thyroid remnant and nodal metastases, initial postoperative radioiodine (RAI) diagnostic whole-body scintigraphy showed abnormal diffusely increased linear band-like uptake in the thorax corresponding to the esophageal contour, raising suspicion of lower esophageal obstruction. Retrospective inquiry revealed a history of long-standing, progressive dysphagia. Findings of computed tomography, barium swallow study, and esophageal manometry were consistent with achalasia cardia. She underwent high-dose RAI therapy for PTC and laparoscopic cardio-myotomy for achalasia cardia. This case report aims to familiarize nuclear medicine physicians with the appearance of achalasia cardia on RAI scintigraphy, which may mask surrounding lymph nodal or vertebral metastases. Such a finding when encountered should also prompt further work-up and appropriate management.
Steroid-induced Activated White Adipose Tissue on FDG PET-CT
Authors: Rehman Ashique , Singhal Tejasvini , Singh Parneet , Parida Girish Kumar , Agrawal Kanhaiyalal , Patro P. Sai Sradha , Subudhi T. Kishan , Gupta Sunita
Published: January 2025

White adipose tissue (WAT) generally has negligible glucose utilization and thus, shows no or insignificant Fluorine-18 fluoro D-glucose (FDG) uptake. However, corticosteroids can cause altered biodistribution of FDG with increased uptake in WAT. We hereby describe a case of immune complex-mediated glomerulonephritis showing diffusely increased FDG uptake in WAT secondary to high-dose corticosteroid therapy.
Predictors of recurrent febrile seizure in children aged from 6 months to 5 years: A cross-sectional study
Authors: Muttath Anand , Antony Thomas , Santhakumar Rati , Xavier Rose , Mathew Jassal
Published: January 2025

Objective:

To study the clinical profiles of children with febrile seizures, comparing those with single episodes to recurrent cases, and identify predictors of recurrence. In addition, to develop a scoring system to predict recurrence after the first febrile seizure, and identify modifiable risk factors to mitigate recurrence risks.

Methods:

This cross-sectional study included children aged 6 months to 5 years with typical febrile seizures, seen as inpatients or outpatients of the Department of Pediatrics at a tertiary care teaching hospital. Data were collected via parent interviews, physical exams, and laboratory tests. The questionnaire covered demographics, antenatal, natal, and postnatal events, seizure history, family history, immunization, daycare attendance, and fever management. Clinical evaluations ruled out central nervous system infections and fever causes were diagnosed per ICD-10 at discharge. Laboratory tests assessed anemia, dyselectrolytemia, and hypoglycemia. Data were analyzed in SPSS Version 25 using descriptive statistics, t-tests, Chi-square tests, and odds ratios with 95% confidence intervals (CI), with significance set at P<0.05.

Results:

451 children were included in this study. Low birth weight (OR=2.60, 95% CI=1.12-6.33, P=0.026), age at first episode <12 months (OR=0.28, 95% CI=0.16-0.48, P>0.001), family history of febrile seizure (OR=5.21, 95% CI=2.92-9.28, P>0.001), no intermittent prophylaxis (OR=15.25, 95% CI=7.05-32.90, P>0.001), treatment for fever (OR=0.26, 95% CI=0.13-0.51) and low socioeconomic status (OR=5.87, 95% CI=3.32-10.38) were significantly associated with recurrent febrile seizures.

Conclusions:

Low birth weight, age at first episode ⩽12 months, family history of febrile seizure, no intermittent prophylaxis, inadequate treatment for fever and low socioeconomic status were significant risk factors for having recurrent febrile seizures in children aged from 6 months to 5 years.
Kidney Dysfunction Prediction by Serum Adropin in Type 2 Diabetes Iraqi Patients
Authors: Abdulfattah Sarah Wabil , Abdulsattar Sura Ahmed , Rahmah Abbas Mahdi
Published: January 2025

Background:

Diabetic nephropathy (DN) is a problem that arises from microvascular complications with type 2 diabetes mellitus (T2DM). It especially denotes the deterioration of renal function. Adropin, a regulatory peptide hormone, has attracted interest for its potential role in regulating metabolism, specifically glucose metabolism and insulin resistance.

Objective:

To assess Adropin’s role in the identification and severity of T2DM nephropathy.

Methods:

A cross-sectional study which involved an 88 patients with DN was conducted in the National Diabetes Center/Mustansiriyah University during the period from October 2023 to April 2024. Body mass index, blood analysis for sugar levels, lipid profile, renal function test, and albumin to creatinine ratio in urine were conducted. In addition, the content of human adropin was evaluated using an enzyme-linked immunosorbent assay.

Results:

Much more fasting blood sugar, glycated hemoglobin, insulin, homeostasis model assessment insulin resistance, cholesterol, triglycerides, low-density lipoprotein (LDL) and very LDL, urea, and creatinine were found in the microalbuminuria and macroalbuminuria groups of DN patients than in the normoalbuminuria group. The amount of adropin in the blood was lowered in people with microalbuminuria and macroalbuminuria (245.91 ± 59.47 and 179.86 ± 51.96 pg/ml, respectively) than in people with normoalbuminuria (377.97 ± 98.69 pg/ml) as well. While the subject attempts to identify the difference between the groups of DN, adropin works very well and is very sensitive.

Conclusion:

This study establishes a correlation between reduced adropin levels and impaired kidney function in individuals diagnosed with T2DM. Adropin content in the serum is able to serve as a biomarker for the early recognition of DN, by its role in glucose metabolism and insulin resistance.
Log canonical thresholds and coregularity
Authors: Figueroa Fernando , Moraga Joaquín , Peng Junyao
Published: January 2025

We prove the ascending chain condition for log canonical thresholds of bounded coregularity.
Mixed $\ell$-adic complexes for schemes over number fields
Authors: Morel Sophie
Published: January 2025

If

X

is a variety over a number field, Annette Huber has defined a category of “horizontal” (or “almost everywhere unramified”)

\ell

-adic complexes and

\ell

-adic perverse sheaves on

X

. For such objects, the notion of weights makes sense (in the sense of Deligne), just as in the case of varieties over finite fields. However, contrary to what happens in that last case, mixed perverse sheaves (or mixed locally constant sheaves) on

X

do not have a weight filtration in general, even when

X

is a point. The goal of this paper is to show how to avoid this problem by working directly in the derived category of the abelian category of perverse sheaves that do admit a weight filtration. As an application, the method of the author to calculate the intermediate extension of a pure perverse sheaf using weight truncations apply over any finitely generated field, and not just over a finite field.
Convergence of the environment seen from geodesics in exponential last-passage percolation
Authors: Martin James B. , Sly Allan , Zhang Lingfu
Published: January 2025

A well-known question in planar first-passage percolation concerns the convergence of the empirical distribution of weights as seen along geodesics. We demonstrate this convergence for an explicit model, directed last-passage percolation on

\mathbb{Z}^{2}

with i.i.d. exponential weights, and provide explicit formulae for the limiting distributions, which depend on the asymptotic direction. For example, for geodesics in the direction of the diagonal, the limiting weight distribution has density

(1/4+x/2+x^{2}/8)e^{-x}

, and so is a mixture of Gamma(

1,1

), Gamma(

2,1

), and Gamma(

3,1

) distributions with weights

1/4

,

1/2

, and

1/4

respectively. More generally, we study the local environment as seen from vertices along geodesics (including information about the shape of the path and about the weights on and off the path in a local neighborhood). We consider finite geodesics from

(0,0)

to

n\boldsymbol{\rho}

for some vector

\boldsymbol{\rho}

in the first quadrant, in the limit as

n\to\infty

, as well as semi-infinite geodesics in direction

\boldsymbol{\rho}

. We show almost sure convergence of the empirical distributions of the environments along these geodesics, as well as convergence of the distributions of the environment around a typical point in these geodesics, to the same limiting distribution, for which we give an explicit description.We make extensive use of a correspondence with TASEP as seen from an isolated second-class particle for which we prove new results concerning ergodicity and convergence to equilibrium. Our analysis relies on geometric arguments involving estimates for last-passage times, available from the integrable probability literature.
Denjoy–Carleman solvability of Vekua-type periodic operators
Authors: Kirilov Alexandre , Almeida de Moraes Wagner Augusto , Meyer Tokoro Pedro
Published: January 2025

This paper explores the solvability and global hypoellipticity of Vekua-type differential operators on the

n

-dimensional torus within the framework of Denjoy–Carleman ultradifferentiability. We provide the necessary and sufficient conditions for achieving these global properties in the case of constant-coefficient operators, along with applications to classical operators. Additionally, we investigate a class of variable coefficients and establish conditions for its solvability.
A new moment determinacy condition for probability distributions
Authors: Wei Yixi , Zhang Rui
Published: January 2025

В этой статье мы предлагаем условие на вероятностное распределение, которое позволяет нам однозначно определить распределение по всем его моментам. Это условие применимо как к случаю Гамбургера (распределения на всей действительной прямой), так и к случаю Стилтьеса (распределения на положительной полупрямой). Предложенное условие легко проверяется и связано как с условием Лина, так и с обратным условием Крейна. Кроме того, мы приводим еще одно условие определенности для проблем моментов Гамбургера и Стилтьеса, которое похоже на условие Лина, но не требует обратного условия Крейна.
Józef Białynia-Chołodecki (1852–1934) – badacz i popularyzator historii powstania styczniowego
Authors: Kozłowski Damian
Published: January 2025

Józef Białynia-Chołodecki was a publicist, social worker, historian and one of the most active non-professional researchers of the post-partition history of Poland at the turn of the 19th and 20th centuries and the interwar period. The January Uprising held a special place in his historiographical work. Due to his family’s involvement and his own participation as a witness to the uprising, he developed a special interest in the events of 1863/1864. During his lifetime, he took part in many activities aimed at cultivating the memory of the fallen insurgents, as well as helping veterans and their families. His historical work had a popularizing, but often also pioneering character.
ГЕОФІЗИЧНІ МЕТОДИ КОНТРОЛЮ ЯКОСТІ МІНЕРАЛЬНОЇ СИРОВИНИ В СИСТЕМІ УПРАВЛІННЯ ВИДОБУТКОМ РУД ЧОРНИХ МЕТАЛІВ
Authors: Азарян Володимир
Published: January 2025

У монографії розглянуто основні методи оперативного контролю та управління якістю руд чорних металів у гірничорудній промисловості: ядерно-фізичні, магнітометричні, фотометричні та інклінометричні. Наведено результати математичного моделювання процесів, які були використані для розробки та впровадження у виробництво мобільних, стаціонарних пристроїв та мікропроцесорних систем оперативного контролю та управління якістю мінеральної сировини.
Монографія розрахована на інженерно-технічний персонал гірничодобувних та гірничопереробних підприємств, а також наукових співробітників, магістрів, аспірантів та студентів гірничих вузів.
Новая волна в исследовании методо­логических вопросов отечественной юриспруденции (Рец. на кн.: Метатео­рия и методология права и правопорядка : монография / кол. авторов ; под ред. д-ра юрид. наук А. В. Аверина, д-ра юрид. наук, проф. М. Л. Давыдовой. Владимир : Владимирский филиал РАНХиГС, 2023. 249 с.)
Authors: Лапшин В.Е.
Published: January 2025

Методология права имеет важнейшее значение в познании явлений правовой действительности. Исследование проблем права и право­порядка неизбежно связано с обращением к методологическим вопросам, которые должны быть решены с учетом контекстуальности и многоуровности права и правопорядка. Именно в этом ключе рассматриваются общетеоре­тические и отраслевые проблемы в коллективной монографии «Метатеория и методология права и правопорядка». В качестве основы метатеории права рассматриваются правовые метафеномены. В контексте изучения сущности правопорядка исследованы инструментальные возможности конструктивиз­ма и поликонтекстуальности. Значительное место уделяется анализу мето­дологических аспектов общеправовых и конституционно-правовых иссле­дований (контент-анализ, коэволюционный процесс, умное регулирование, методология правового регулирования, методология юридической техники, методология теории правоприменения, конституционный правопорядок и др.).

The methodology of law is of crucial importance when studying legal reality phenomena. Consideration of problems of law and the rule of law is inevitably associated with addressing methodological issues that should be resolved taking into account the contextuality and multilevel nature of law and the rule of law. General theoretical and sectoral problems are considered in the monograph "Metatheory and Methodology of Law and Order". Legal metaphenomena are considered as the basis of the meta-theory of law. In the context of studying the essence of the rule of law, instrumental possibilities of constructivism and polycontextuality are studied. Considerable attention is paid to the analysis of methodological aspects of general legal and constitutional legal research (content analysis, coevolutionary process, smart regulation, methodology of legal regulation, methodology of legal technique, methodology of the law enforcement theory, constitutional law and order, etc.).
Теоретическое изучение критико-правового метода в разрезе науки уголовного права
Authors: Смирнова П.В.
Published: January 2025

Статья посвящена научной критике как одному из значимых методов познания правовой действительности. В условиях постклассическо­го этапа становления научной мысли сформировался плюрализм взглядов на методологию уголовно-правой науки. Особенно роль научной критики прослеживается в ее применении при существующем реформировании уго­ловного законодательства, которое вступило в новую стадию - активного использования института административной преюдиции. В юридической ли­тературе все чаще ведется дискуссия о значении и сущности феномена на­учной критики. В связи со сложностью предмета уголовного права возникает существенная необходимость определения научно обоснованных методик применения критико-правового метода при проведении правовых исследо­ваний.

The article is devoted to scientific criticism as one of the significant methods of legal reality cognition. In the conditions of the postclassical stage of the formation of scientific thought, pluralism of views on the methodology of criminal law science is formed. The role of scientific criticism is especially evident in its application in the existing reform of criminal legislation, which has entered a new stage - the active use of the institution of administrative prejudice. There is an increasing discussion in the legal literature about the meaning and essence of the phenomenon of scientific criticism. Due to the complexity of the subject of criminal law, there is an essential need to determine scientifically sound methods for applying the critical legal method in legal research.
PROBLEMATIKA KONFIGURACIJE 1D HIDRODINAMIČKOG MODELA NA SLIVOVIMA MALE I SREDNJE VELIČINE
Authors:   Institute for water management Jaroslav Černi, Serbia, Marisavljević Ivan , Stojadinović Luka ,   Institute for water management Jaroslav Černi, Serbia, Prohaska Ognjen ,   Institute for water management Jaroslav Černi, Serbia, Milovanović Marija ,   Institute for water management Jaroslav Černi, Serbia, Bogdanović Nenad ,   Institute for water managements Jaroslav Černi, Serbia, Cvetković Aleksandar ,   Institute for water management Jaroslav Černi, Serbia
Published: January 2025

When modeling flows rivers with complex dynamics,
issues may arise related to water overflow from the main
channel and flow through inundation areas, as well as
interactions with various objects within the floodplain
zone (such as bridges, access roads, culverts, etc.). In
the context of a one-dimensional hydrodynamic model,
these phenomena are modelled through various internal
boundary conditions, formation of parallel flows, and
similar approaches. However, in cases where a 1D
hydrodynamic model is used in operational applications
(e.g., in early warning systems), detailed simulation of
all phenomena can significantly slow down the model
execution to the point where it becomes impractical.
Therefore, it is necessary to find a configuration for a
1D hydrodynamic model that adequately simulates
complex flows with as few additional elements as
possible. It is proposed to develop a 2D hydrodynamic
model, based on whose results it is possible to determine
the most influential phenomena in flood wave
transformation. Based on these conclusions, it is
possible to determine the optimal configuration for a 1D
hydrodynamic model that achieves satisfactory model
accuracy within an acceptable computational time. The
application of this methodology will be demonstrated in
the case of the Tamnava River, within the hydraulic
model used in the Kolubara Flood Early Warning
System.
RAZVOJ I ZNAČAJ HIDROGEOLOŠKIH ISTRAŽIVANJA U REPUBLICI SRBIJI
Authors:   University of Belgrade, Faculty of Mining and Geology, Serbia, Milanović Saša , Vasić Ljiljana ,   University of Belgrade, Faculty of Mining and Geology, Serbia
Published: January 2025

The paper presents a historical overview of the
development of hydrogeological research in Serbia, as
well as their importance in modern society. Although
this topic requires much more space than is shown in the
following paper, a general sublimation of the available
data was done, in order to present the importance of the
hydrogeological profession from science to applied
research. The paper deals with several significant parts,
from a review of the short history of the development of
hydrogeology in Serbia, through the presentation of the
hydrogeological characteristics of Serbia and legal
regulations related to groundwater, to the current state
of research and extraction of groundwater in Serbia.
Particular importance in the paper is given to different
types of groundwater uses for different purposes, such
as use for water supply, use of mineral and thermomineral water for the needs of spa tourism for medical
and recreational purposes, as well as use of subthermal
and thermal resources for the needs of heat energy
production, as well as and in the electricity production
sector. In accordance with the sustainable use and
management of groundwater resources, the paper gives
special importance to the protection and monitoring of
groundwater.
SOFTVER “WELL-DRAIN” ZA PRORAČUN TRENUTNOG SLEGANJA TLA USLED SNIŽENJA NIVOA PODZEMNE VODE
Authors:   University of Belgrade, Faculty of Civil Engineering, Serbia, STANIĆ Filip , VASILIĆ Željko ,   University of Belgrade, Faculty of Civil Engineering, Serbia, RANĐELOVIĆ Anja ,   University of Belgrade, Faculty of Civil Engineering, Serbia
Published: January 2025

The use of pumping wells to lower groundwater during
the construction phase is standard practice worldwide,
but the calculation of the consequent soil subsidence is
often neglected. The groundwater lowering causes a
decrease in pore pressure and an increase in effective
stress, leading to soil compaction and subsidence. These
deformations are mostly permanent and can be described
using Terzaghi's model which assumes nonlinear
correlation between the effective sress in the soil and
deformations, because of the non-constant value of the
compressibility module. This model is integrated into the
WELL-DRAIN software, developed at the University of
Belgrade – Faculty of Civil Engineering. This sotware
contains two moduls, where the first one is related to the
calculation of the spatial lowering of groundwater in time
due to water extraction from wells, while the second one
is related to the computation of the consequent soil
subsidence while using the groundwater lowering results
as an intput. WELL-DRAIN has already been applied in
engineering practice, while this paper presents the soil
subsidence results obtained for a location in Belgrade,
where lowering the groundwater level by 9 meters is
necessary for constructing a building with three
underground floors. For this purpose, 22 wells with total
capacity of 176 L/s are planned to be built along the
excavation line. The results indicate the significant soil
subsidence of over 7 cm outside the excavation zone,
prompting an alternative solution to avoid endangering
surrounding buildings and infrastructure
CORRELATION BETWEEN MAGNESIUM AND CALCIUM LEVELS ON HEALTH IN THE ELDERLY WITH DEGENERATIVE TYPE 2 DIABETES MELLITUS
Authors: Wijayanti Christina Destri Wiwis , Ayu Diva Sukma , Mariska Nabila Refi
Published: January 2025

Diabetes Mellitus (DM) is a metabolic disorder characterized by elevated blood glucose levels due to decreased insulin secretion from pancreatic beta cells or insulin resistance. Magnesium and calcium are essential minerals that play crucial roles in various enzymatic activities, significantly influencing important biological functions, particularly in relation to metabolic syndrome. The purpose of the research is to investigate the correlation between magnesium and calcium levels in the serum of elderly individuals with type 2 diabetes mellitus. The study method is descriptive observation with cross-sectional studies. The examination sample used 25 serum samples of people with diabetes with age inclusion criteria over 50 years old without any other degenerative diseases. The analysis of the data from the results of the study was then carried out by the SpSS test of the relationship between magnesium levels and the condition of type 2 DM, especially in the context of aging and its impact on metabolic health. Based on the examination of magnesium levels using the xylidil blue method, 23 patients (92%) showed normal results, while 2 patients (8%) showed numbers above normal on average. There was no significant relationship between blood sugar and magnesium levels, blood sugar with calcium levels, and between magnesium with calcium with a significance of p 0.058, p 0.179, and p 0,114, respectively. The findings of this study could enhance the understanding of the complex interactions between these essential minerals and their potential roles in managing metabolic syndrome, ultimately contributing to better health outcomes for older adults with DM.
ANALISIS KESULITAN BELAJAR PESERTA DIDIK POLITEKNIK ILMU PELAYARAN MAKASSAR TERHADAP MATA PELAJARAN FISIKA PADA MATERI KECAPATAN DAN PERCEPATAN
Authors: Setyaningsih Agustina , Fauziah Gradina Nur , Napsawati Napsawati
Published: January 2025

Analysis of Learning Difficulties of Students of Politeknik Ilmu Pelayaran Makassar in Physics Subjects on Speed and Acceleration Material. This study aims to identify students learning difficulties in applied physics courses at Politeknik Ilmu Pelayaran Makassar especially on the concept of speed and acceleration. This study is a descriptive study with a population of 240 students in the engineering study program in the first semester of the 2024/2025 academic year and a sample of 150 people based on the Taro Yamane formula. Data collection techniques in this study were written tests and interviews. The research instrument in the form of essay questions was used to measure the difficulty of calculating, mastery of concepts, interpretation of symbols, and unit conversion, and interviews aimed to determine the factors that cause learning difficulties experienced by students. The conclusion of this study shows that the main difficulty of students in learning physics lies in mastery of concepts (20.3%), followed by difficulty in converting units (17.5%) and interpreting symbols (15.9%). The lowest difficulty in calculation (1.1%). Factors such as ineffective teaching methods and lack of supporting materials affect conceptual understanding. Therefore, a more varied learning approach, the use of visual aids, and the improvement of basic mathematical skills are needed to improve students' knowledge of physics.
EFEKTIVITAS MODEL PEMBELAJARAN INKUIRI TERBIMBING PADA PEMBELAJARAN FISIKA SISWA KELAS VII SMP IT ANNAJIYAH
Authors: Wandira Ayu , Gumay Ovilia Putri Utami
Published: January 2025

Penelitian ini bertujuan untuk memahami kegunaan model pembelajaran inkuri terbimbing ke dalam pembelajaran fisika peserta didik kelas VII SMP IT ANNAJIYAH. Penelitian ini adalah menggunakan penelitian kualitatif. Jenis dalam penelitian ini merupakan deskriptif. Metode penelitian yang digunakan adalah eksperimen semu (Quasi Eksperimen). Subyek penelitian ini merupakan peserta didik yng mengikuti prosedur pembelajaran fisika  dengan menerapkan acuan inkuiri terbimbing. Pendekatan penelitian yang digunakan adalah observasi kelas secara langsung untuk menilai partipasi siswa, pemahman konsep, dan respon siswa terhadap proses pembelajaran. Metode pembelajaran penyelidikan terbimbing dirancang agar peserta didik berkontribusi secara aktif pada tahap eksplorasi, investigasi, dan pemecahan masalah dibawah bimbingan guru. Penelitian ini juga mengamati adanya peningkatan minat dan partisipasi peserta didik dalam kegiatan pembelajaran fisika menerapkan model penyelidikan terbimbing. Hasil observasi menegaskan bahwa model ini efektif dalam meningkatkan partisipasi siswa ketika proses pembelajaran dan penugasan materi terhadap teori fisika yang mana dipelajari. Maka dari itu, pendekatan pembelajaran inkuiri terbimbing dapat berfungsi sebagai pendekatan yang berhasil dalam pembelajaran fisika ditingkat menengah. Setelah dilakukan verifikasi keefektifan model pembelajaran berbimbingan melalui inkuiri.
Investigating Factors such as Frustration, Past Trauma, and High Aggression Levels that Contribute to Violent Conflicts in both Interpersonal and Social Contexts
Authors: Lolai Muhammad Bakhsh , Batool Bushra , Iqbal Muhammad Jawed , Jawed Aamna
Published: January 2025

This study explores the contribution of frustration, previous trauma, and aggression to violent conflict among university students, examining their psychological and structural determinants. Using a quantitative approach, a diverse sample of 400 university students from Punjab, Pakistan, responded to a self-administered questionnaire. Data analysis identified substantial relationships between variables. Frustration had a close association with violence (r = 0.65, p < 0.01), and past trauma strongly related to aggression (r = 0.72, p < 0.01), the latter of which significantly predicted violence (? = 0.63, p < 0.01). Aggression, furthermore, showed a moderate relationship with violence with a correlation of r = 0.59, p < 0.01, while explaining 27.04% of the variance in violence. Post-hoc analyses revealed demographic differences, with males and urban students having higher associations between aggression, trauma, and violence. Ethical considerations, including informed consent, confidentiality, and data protection, were maintained throughout the research. These results underscore the urgent need for interventions focused on frustration, trauma, and structural disparities to reduce violence.
Sistem Pendukung Keputusan dalam Menentukan Kelayakan Pinjaman Karyawan Menggunakan AHP-TOPSIS pada PT XYZ
Authors: Sulistiyaningsih Febriani
Published: January 2025

Sistem pendukung keputusan merupakan suatu sistem yang digunakan oleh para manajerial tingkat atas dalam melakukan pengambilan keputusan. Sistem pendukung keputusan memiliki beberapa metode yang dapat digunakan diantaranya yaitu metode AHP dan TOPSIS. Metode AHP (Analytical Hierarchy Process) merupakan salah satu metode pengambilan keputusan yang lebih menitik beratkan dalam perhitungan bobot kriteria. Sedangkat metode TOPSIS (Technique for Order of Preference by Similarity to Ideal Solution) merupakan salah satu metode pengambilan keputusan yang cocok digunakan untuk menghitung hasil akhir dan perangkingan. Penentukan kelayakan pinjaman karyawan menggunakan metode AHP dan TOPSIS menghasilkan nilai yang objektif karena dilakukan perhitungan bobot kriteria dan hasil akhir sesuai dengan metode yang digunakan.
Klasterisasi Rumah Sakit berdasarkan Kunjungan Pasien menggunakan Algoritma K-Means: Data 2019-2023
Authors: Mayola Liga , Hafizhb M. , Syahputra Hadi Syahputrac
Published: January 2025

Hospitals play a vital role in public health services. Every day, patients visit hospitals to receive medical care. Over time, patient visit data will continue to accumulate, creating a massive volume of data that requires strategic management. This situation necessitates an in-depth analysis to understand patient visit patterns, aiding the effective management of hospital resources. This study aims to classify hospitals based on the number of patient visits over the past five years, providing strategic insights for resource management, facility planning, and improving the quality of healthcare services. The hospital classification process utilizes the K-Means Clustering Algorithm. The research data was obtained from the Satu Data Sumbar website. The patient visit data is categorized into three clusters: Cluster 1 (K1) represents hospitals with very high visit intensity, Cluster 2 (K2) represents hospitals with moderate visit levels, and Cluster 3 (K3) represents hospitals with low visit levels. These findings provide valuable insights for policymakers to optimize healthcare services.
Tren Pengembangan Sistem Pendukung Keputusan Metode Simple Additive Weighting: Systematic Literature Review
Authors: Rahman Ikhlasul Aulia
Published: January 2025

Kemajuan transformasi digital telah membawa dampak pada kompleksitas proses pengambilan keputusan di berbagai sektor, terutama dengan meningkatnya volume data yang besar dan beragam. Dalam konteks ini, diperlukan alat yang efisien untuk mengevaluasi alternatif multi-kriteria secara objektif. Simple Additive Weighting (SAW) telah muncul sebagai salah satu metode yang banyak digunakan dalam Sistem Pendukung Keputusan (SPK). Namun, kajian sistematis yang membahas pengembangan dan penerapan metode ini dalam berbagai konteks masih sangat terbatas. Penelitian ini bertujuan untuk melakukan Systematic Literature Review (SLR) terhadap pengembangan SPK berbasis SAW dengan fokus pada identifikasi platform aplikasi, metode perancangan, dan manfaat penerapannya. Dalam penelitian ini, digunakan metode Systematic Literature Review dengan pendekatan yang mengikuti panduan Kitchenham. Hasil penelitian menunjukkan bahwa platform berbasis web mendominasi pengembangan SPK karena fleksibilitas, kemudahan akses, dan kemampuannya untuk mendukung pengambilan keputusan secara real-time. Selain itu, metode perancangan Prototyping sering digunakan karena memungkinkan penyesuaian sistem yang dinamis terhadap kebutuhan pengguna. Penerapan metode SAW secara konsisten terbukti meningkatkan akurasi, efisiensi waktu, transparansi, dan kepercayaan pengguna dalam proses pengambilan keputusan.