bluuebunny/crossref_metadata_2025 huggingface dataset:
Game Floating City Islands untuk Meningkatkan Kompetensi Pengetahuan dan Minat Belajar Matematika pada Masa Pembelajaran Jarak Jauh
Authors: Ardiyanto Doni Setiyo
Published: March 2023

Penelitian ini bertujuan untuk mendeskripsikan kefektivan penggunaan “Game Floathing City Islands” dalam pembelajaran matematika pada masa Pembelajaran Jarak Jauh (PJJ) untuk meningkatkan kompetensi pengetahuan dan minat belajar matematika. Metode yang digunakan dalam tulisan ini adalah penelitian kuantitatif deskriptif. Subjek dalam penelitian ini adalah 32 siswa kelas VIII C Sekolah Menengah Pertama Negeri 1 Tempuran yang melakukan pembelajaran melalui PJJ daring. Inovasi pembelajaran yang dibuat mengandung unsur rekreatif yaitu sebuah game edukasi yang diberi “Floathing City Islands”. Game ini berbasis materi atau soal matematika untuk persiapan Penilaian Akhir Tahun (PAT). Game disusun menggunakan aplikasi Articulate Storyline 3. Hasil penelitian menunjukkan bahwa (a) “Floating City Islands” dapat diaplikasikan pada pembelajaran matematika yang bermakna dan menyenangkan pada saat PJJ atau BDR. (b) Game ini efektif untuk meningkatkan kompetensi pengetahuan dan minat belajar siswa.
Kajian Reflektif Pembatik 2021 untuk Perbaikan Pembelajaran Berbasis MOOC
Authors: Abduh Moch. , Utami Garti Sri , Sumarno Sumarno
Published: March 2023

Kompetensi teknologi pendidikan sangat dibutuhkan bagi guru di abad 21. Sebagaimana dinyatakan oleh UNESCO ICT Competency Framework for Teacher versi 3, penggunaan teknologi dan kompetensi dasar TIK dalam keterampilan abad 21 sangat membantu guru dalam penerapan teknologi pendidikan. Artikel ini mengkaji tentang evaluasi PembaTIK 2021, Tujuan penelitian ini adalah untuk mengevaluasi PembaTIK 2021 tentang bagaimana menentukan dampak MOOC menggunakan pendekatan evaluasi pelatihan empat level Kirkpatrick, dengan kajian pada dua level evaluasi yaitu Reaction dan Learning Level. Penelitian ini menggunakan metode survei. Survei dilakukan untuk menjaring respon peserta Program PembaTIK 2021 Tingkat Pra Level dan Level 1 yang sebagian besar adalah guru di semua jenjang pendidikan dari 34 provinsi di Indonesia. Hasilnya menunjukkan bahwa MOOC secara efektif mencapai meningkatkan keahlian guru dalam teknologi pendidikan. MOOC telah berhasil mengubah sikap guru terhadap pemanfaatan teknologi dan TIK dasar, menciptakan sumberdaya pendidikan untuk siswa mereka dan menggunakan pendekatan pengajaran yang inovatif di kelas mereka. Kesimpulan terjadi peningkatan kompetesi TIK guru melalui pembelajaran berbasis TIK dan platform MOOC.
El despegue del turismo en Puno y su contribución al desarrollo regional
Authors:   Universidad Nacional del Altiplano, Puno, Perú, Ccama Uchiri Faustino , Acero Cáceres Santusa ,   Universidad Nacional del Altiplano, Puno, Perú
Published: March 2023

One of the problems in the rural areas of the Puno region is the persistence of poverty, despite the fact that the region has agricultural, tourism, mining, cultural and ecological resources. This document analyzes the takeoff of tourism in the Puno region as an alternative that contributes to regional development. The objective is to systematize the takeoff of tourism activity in Puno and its contribution to regional development. The specific objectives are: to know the factors that contribute to the takeoff of tourism in Puno, measure the role of tourism in the economic growth of the region, and propose policies to continue its growth. The tourist resources available to the region, private and public investments, the offer of new ecological and cultural products were analyzed: such as the Candelaria festival and the new products of community rural tourism and public policies at national and regional level. Likewise, the number of arrivals, days of stay, most visited places and the profile of the foreign tourist are analyzed.
Molecular surveillance reveals the emergence and dissemination of NDM-5-producing Escherichia coli high-risk clones in Germany, 2013 to 2019
Authors: Hans Jörg B , Pfennigwerth Niels , Neumann Bernd , Pfeifer Yvonne , Fischer Martin A , Eisfeld Jessica , Schauer Jennifer , Haller Sebastian , Eckmanns Tim , Gatermann Sören , Werner Guido
Published: March 2023

Background

Carbapenemase-producing Enterobacterales (CPE) are rapidly increasing worldwide, also in Europe. Although prevalence of CPE in Germany is comparatively low, the National Reference Centre for Multidrug-resistant Gram-negative Bacteria noted annually increasing numbers of NDM-5-producing Escherichia coli isolates.

Aim

As part of our ongoing surveillance programme, we characterised NDM-5-producing E. coli isolates received between 2013 and 2019 using whole genome sequencing (WGS).

Methods

From 329 identified NDM-5-producing E. coli, 224 isolates from known geographical locations were subjected to Illumina WGS. Analyses of 222 sequenced isolates included multilocus sequence typing (MLST), core genome (cg)MLST and single-nucleotide polymorphism (SNP)-based analyses.

Results

Results of cgMLST revealed genetically distinct clusters for many of the 43 detected sequence types (ST), of which ST167, ST410, ST405 and ST361 predominated. The SNP-based phylogenetic analyses combined with geographical information identified sporadic cases of nosocomial transmission on a small spatial scale. However, we identified large clusters corresponding to clonal dissemination of ST167, ST410, ST405 and ST361 strains in consecutive years in different regions in Germany.

Conclusion

Occurrence of NDM-5-producing E. coli rose in Germany, which was to a large extent due to the increased prevalence of isolates belonging to the international high-risk clones ST167, ST410, ST405 and ST361. Of particular concern is the supra-regional dissemination of these epidemic clones. Available information suggest community spread of NDM-5-producing E. coli in Germany, highlighting the importance of epidemiological investigation and an integrated surveillance system in the One Health framework.
Oil to Source Rock Correlation of Besuki Area and its Role in Petroleum System of Banyumas Basin
Authors: Sutadiwiria Yarra , Purwasatriya Eko Bayu , R Cahyaningratri P , Syavitri Dewi , Maulani Mustamina , Giovany Asy’ari Alfin , Ramadhan Anjar Kurnia
Published: March 2023

Banyumas Basin is a basin that has signs of the presence of hydrocarbons, including oil and gasseep on the surface, which indicates active petroleum systems in the subsurface. A lot of oil and gas seeps werefound in Banyumas Basin, including oil seeps in Cipari and Besuki, while gas seeps were found in Mount Wetan,Karanglewas, and also Cipari. Exploration drilling wells have also been carried out, such as the Jati-1 Well, KarangNangka-1, Karang Gedang-1, Tjipari-1, and Mount Wetan-1, but there still has been no significant evidenceof this basin producing hydrocarbons. The TOC value of the outcrop samples taken in Cipari and Besuki have badvalues, while the crude oil has reflected a severe biodegradation process. Both oil seep samples and one extractbitumen contained high bicadinane (R (resin) annotation) and oleanane indicating both oils and extract to have aninput to Tertiary-sourced oils throughout Southeast Asia. Both oil seep samples do not exhibit similarity with theextract source rock. Based on this negative correlation there may be another source rocks in Banyumas Basin, derivedfrom rocks that are not only from Pemali Formation. The existence of this research is expected to be able toadd geological data, especially hydrocarbon geochemical data in Banyumas Basin, so that it can provide evidenceof the prospect and calculation of reserves contained in this basin, and an understanding of the source rock it self.
Análisis comparativo del valor nutricional de la cerveza artesanal y la cerveza industrial
Authors: Mendoza Balcázar Jessica Mercedes , Pihuave Calderón Luigi Fabián , Velásquez Campozano Manuel Rolando
Published: March 2023

El presente artículo se desarrolló con el objetivo realizar un análisis sobre los componentes nutricionales de la cerveza artesanal en contraposición con la cerveza industrial. Se establecieron comparaciones de los valores nutricionales que posee la bebida desarrollada de forma industrial y la artesanal. En el contexto metodológico se estableció un estudio de diseño documental, mostrando resultados de experiencias de varios autores, valores obtenidos conclusiones y hallazgos más representativos. Destacamos la revisión de varias bases de datos: Google Scholar, Library Génesis, se extrajo el contenido y se expuso en el apartado de los resultados. Las conclusiones obtenidas relevantes son que el valor nutritivo de la cerveza artesanal sin importar el cereal que se utilice como base es el fundamento de su mayor concentración de vitaminas y minerales, en comparación con la cerveza industrializada, por los procesos mecánicos que debilitan los componentes alimenticios en la ingesta de la bebida.
PROGRAM PENGASUHAN POSITIF DAN BINA KELUARGA MUDA DI KOTA SEMARANG
Authors: Sakti Hastaning , Rusmawati Diana , Alfaruqy Muhammad Zulfa
Published: March 2023

Pengabdian bertujuan mengembangkan program pengasuhan positif dan bina keluarga muda di Kelurahan Peterongan, Kecamatan Semarang Selatan, Kota Semarang dengan pendekatan intervensi berbasis pemberdayaan keluarga dan pengasuhan positif berbasis Pancasila. Tahapan program direncanakan dalam tiga tahun pelaksanaan. Metode yang dilakukan pada tahun pertama meliputi asesmen kebutuhan warga anti-stunting, asesmen model pengasuhan warga, sosialisasi dan pemberian modul pengasuhan positif, dan sosialisasi makanan bergizi dan penambahan gizi dengan konsumsi telur. Hasil asesmen menunjukkan bahwa elemen masyakarat membutuhkan pelatihan pengasuhan positif dan bina keluarga muda guna membentuk generasi anti-stunting dan sehat mental. Berdasarkan pengasuhan positif berbasis Pancasila, pengasuhan warga sekarang ini didominasi oleh pengasuhan berbasis keterbukaan orangtua kepada anak (19,42) diikuti pengasuhan berbasis kasih sayang (16,72), harga diri (16,39), kelekatan (16,04), dan spiritualitas (15,97). Modul pelatihan pengasuhan positif telah didistrubusikan kepada ibu hamil dan orangtua anak balita sebagai sarana panduan mandiri guna modal dalam pengasuhan. Selain itu, ibu hamil dan anak balita antusias untuk mengkonsumsi telur secara rutin. Kedepan perlu program pendampingan kelompok pengasuhan positif dan pengembangan sistem informasi teknologi mengenai pengasuhan positif.
LESÃO HEPÁTICA ISOLADA POR ARMA DE FOGO: É POSSÍVEL REALIZAR TRATAMENTO NÃO OPERATÓRIO?
Authors: FERREIRA ANDREI RANNIERI D’ÁVILA PEDROSA , Furtado Beatriz Ribeiro Coutinho De Mendonça , Medeiros Camila Soares Barros Fernandes , Figueiredo Camilla Rayane Gomes De , Pontes Catarina Ferreira , Rodrigues Emilly Bruna Soares , Freire Fernando Lucas Pontes , Pontes Isabelly Patrícia , Lucena Laís Schuler de , Santos Marília Gabriela Chalegre
Published: March 2023

O trauma hepático corresponde a 5% das admissões em centros de referência de atendimento ao politraumatizado. Traumas abdominais acomete especialmente o fígado devido ao tamanho e à posição anatômica,
COLETÂNEA DE ESTUDOS EM INTEGRAÇÃO SENSORIAL
Authors: Barbosa Aracely Kalaf , Silva Renata Costa Sá e , Silva Geniele Severiano da , Santos Janine Xavier dos , Gonçalves Letícia Nayara , Corrêa Neide Rossi Borges , Nunes Rayssa Ketery Barbosa , Santos Altamira dos Reis , Aguiar Elísia Sampaio , Caçula Elizângela Gonçalves , Vieira Maria Helena Santana , Silva Talita Luana dos Santos , Montenegro Karina Saunders , Gomes Adrieli Mariara da Silva , Cordeiro Alexandre Melo , Silva Esteferson Danilo Guimarães , Lima Yasmim da Silva , Montenegro Karina Saunders , Pereira Marcella Vieira , Siqueira Giovana Dias de , Moraes Ísis Lorrane Silva de , Mendes Bárbara Ruanna Pinheiro , Santos Hellen Patrícia Oliveira de S. dos , Montenegro Karina Saunders , Moreira Alana de Paula da Silva , Rodrigues Ariell dos Santos , Costa Franciane Alves da , Oliveira Karem Janaina de , Sousa Karina de Souza , Silva Danielle Cristine Martins da , Barbosa Jefferson Eduardo Ribeiro , Sena Meibia Martins , Nogueira Sara Pacheco , Costa Maria de Fátima Góes da , Pereira Ascheley Guidytye Miranda , Loureiro Mirta Melissa Nunes , Souza Samires , Costa Maria de Fátima Góes da , Coelho Ana Carolina Campos , Campedelli Elza Rodrigues , Santos Gisele da Silva , Prestes Kevin Gil de Sousa , Santos Thamila Vitória Nascimento dos , Sousa Drielem da Silva , Braga Eliane Cristina Silva , Carvalho Juliana Medeiros de , Souza Poliana Dias de , Oliveira Priscila Regina de Lima , Costa Maria de Fátima Góes da , Alves Cleomara Martins Nery
Published: March 2023

A presente coletânea de pesquisa em Integração Sensorial, ora publicada sob o título Coletânea Científica em Integração Sensorial, 3º volume, reúne um conjunto de trabalhos científicos conduzido pelas professoras Karina Saunders Montenegro e Maria de Fátima Góes da Costa e pelos discentes da III Turma do curso de Certificação Brasileira em Integração Sensorial, promovido pela Integris Terapias, Cursos e Eventos, em parceria com a Universidade do Estado do Pará (UEPA).
TERAPIA OCUPACIONAL COM INTEGRAÇÃO SENSORIAL PARA TRATAMENTO DE SELETIVIDADE ALIMENTAR EM CRIANÇA COM TEA: ESTUDO DE CASO
Authors: Coelho Ana Carolina Campos , Campedelli Elza Rodrigues , Santos Gisele da Silva , Prestes Kevin Gil de Sousa , Santos Thamila Vitória Nascimento dos , Costa Maria de Fátima Goes da
Published: March 2023

A Integração Sensorial é definida como um processo
neurológico que organiza os sentidos do corpo e do ambiente tornando
possível o uso eficaz desse corpo no ambiente. Através dessa
integração, o sistema nervoso central deve ser capaz de perceber, selecionar, organizar, discriminar, inibir, comparar e associar informações sensoriais e responder de maneira adaptativa (AYRES, 1979).
Prevalence of undiagnosed hypertension and related risk factors in Wad-Medani Alkobra locality in Gezira State, Sudan, 2022
Authors: Sawsan A. Omer  , Mustafa Alhamed  , Mohannad A. Elmubarak  , Mohab A. Elmubarak  , Raghda M. Ibrahim  , Farah S. Ahmed  , Mawada E. Abukoe  , Abubakr E. Elamin
Published: March 2023

Background: Hypertension is defined as blood pressure ≥140/90 mm Hg. It is emerging as one of the major healthcare challenges in low- and middle-income countries. Hypertension is considered as a silent killer and is the leading risk factor for cardiovascular mortality and accounts for a large proportion of premature deaths in developing countries. Most people with hypertension are asymptomatic and are undiagnosed for years. Objectives: This study aimed to find out the prevalence of undiagnosed hypertension and related risk factors among adults in Wad Medani Alkobra locality in Gezira State, Sudan. Methods: A community-based cross-sectional study involving 464 adults in different locations in Wad-Medani Alkobra locality, from June 2022 to August 2022 was performed in collaboration with the Sudanese Society of Hypertension within May Measure Month (MMM) 2022 study. WHO Stepwise Approach to Surveillance (STEPS) questionnaire was used to collect data, and was analyzed by SPSS version 20. Demographics, blood pressure, pulse, and socioeconomic status were measured. Diagnosis of hypertension was defined based on a systolic and diastolic blood pressure of ≥140 mmHg and ≥90 mmHg, respectively and three readings were obtained. Blood pressure was measured in all women and men aged 15 years and above. Results: Total number of study population was 464, males were 239 (52%), females were 225 (48%). Mean age was 45 years. 68 were known hypertensive (15%). Of those who are hypertensive, 27 (39%) had high blood pressure. Undiagnosed hypertension in the study population was found to be 10% (39 individual) which equals to 59.1% from the total number of the populations who had HTN (66). The prevalence of HTN (new and old cases) in this study group was 25%. There was positive relation between high blood pressure and old age, diabetes mellitus increased body weight and sex (more common in males}, P-value was (,0.00, 0.026, 0.014, 0.033) respectively. Conclusions: The prevalence of hypertension was high and associated with some modifiable risk factors which should be addressed. Frequent screening and proper treatment is required to prevent complications of this hidden epidemic.
ULUSLARARASI HUKUK ÇERÇEVESİNDE KANAL İSTANBUL’DAN OLASI GEÇİŞ REJİMLERİ VE MONTRÖ BOĞAZLAR SÖZLEŞMESİ AÇISINDAN TAŞIDIĞI RİSKLER
Authors: KOCA Selçuk
Published: March 2023

Kanal İstanbul projesiyle, İstanbul boğazına paralel ve alternatif bir suyolu açılması planlanmaktadır. Gerçekleşmesi halinde açılacak kanaldan geçişlerin ücretli olması öngörülmektedir. Montrö Boğazlar Sözleşmesi kapsamında İstanbul Boğazından geçiş rejimi zararsız geçişe benzeyen sui generis bir rejimdir ve ücretsizdir. Kanalın açılması ve gemilerin kanalı kullanmaya zorlanması Montrö Boğazlar Sözleşmesi’nin varlığını tehlikeye atacak niteliktedir. Ayrıca sözleşmeye taraf devletler, kanal sebebiyle “rebus sic stantibus” ilkesi çerçevesinde sözleşmenin feshini veya tadilini talep edebilir. Özellikle Rusya-Ukrayna savaşındaki gelişmelerde de görüldüğü üzere, Türkiye’nin ve Karadeniz’in güvenliğini önceleyen Montrö Boğazlar Sözleşmesi’nin korunması uluslararası toplumun çıkarınadır. Makalede, Kanal İstanbul projesinin Montrö Sözleşmesi açısından taşıdığı riskler ve kanaldan geçiş rejiminin sözleşmeye uygun olması amacıyla nasıl düzenlenebileceği ele alınacaktır.
An Integrated Framework for Studying How Schools Respond to External Pressures
Authors: Diehl David K. , Golann Joanne W.
Published: March 2023

The changing educational landscape requires new organizational frameworks to understand how schools and universities make sense of and respond to broader institutional forces like accountability, diversity, and the market. In this article, we draw on recent innovations in organizational theory to propose a model that identifies two general processes through which pressures from the environment shape educational practice in schools: filtering and local adaptation. We review three areas where researchers have studied filtering and local adaptation—routines, sensemaking, and networks—to illustrate how these processes are currently being applied in education and how this work can be extended. We also identify studies that have begun to integrate these different areas of scholarship and propose directions for future research. This article offers education researchers new to the field conceptual tools for guiding their analysis and assists more seasoned researchers in situating their studies in a broader context of institutional maintenance, change, and heterogeneity.
Vitamin D Deficiency in a Cohort of Neapolitan Pregnant Women: Do We Really Live in the City of the Sun?
Authors: Sarno Laura , Carlea Annunziata , Cabaro Serena , Aquino Carmen Imma , Mantelli Dalila , Perruolo Giuseppe , Formisano Pietro , Guida Maurizio , Terracciano Daniela
Published: March 2023

Background: Insufficient serum 25-hydroxyvitamin D [25(OH)D] levels are a global public health issue, and pregnant women are a significant at-risk group. We aimed to assess maternal serum 25(OH)D concentrations in a cohort of Neapolitan pregnant women and the association with dietary habits, to define which patients are at increased risk of hypovitaminosis and how we can identify them. Methods: This was a prospective observational study. We included 103 pregnant women attending a routine third trimester obstetric examination. Information on obstetrical history and socio-demographic characteristics were obtained through interviews and medical records. Vitamin D intake was assessed using a food frequency questionnaire. Serum 25(OH)D concentration was measured by DiaSorin Liaison and the cut-off value for deficiency was set at 20 ng/mL. Results: Among the 103 pregnant women recruited, 71 (68.9%) were Vitamin D deficient (mean value 12.6 ± 0.5 ng/mL). No statistically significant differences were found between the women involved in the study for: maternal age, pre-pregnancy body mass index (BMI), gestational weight gain, and gestational age at investigation. Women with hypovitaminosis reported a significantly lower intake of milk/yoghurt, cheeses/dairy products and fish. Maternal hypovitaminosis D significantly correlated with low birth weight. Conclusions: Our study confirms that Vitamin D deficiency is a common finding also in sunny areas. Patients with low level of Vitamin D reported a lower intake of food rich of this micronutrient. An accurate anamnesis can be an easy way to identify pregnant women at risk of hypovitaminosis D for whom screening and supplementation can be suitable.
Analysis of 783 Cases of Total Laparoscopic Hysterectomy for Benign Indications: Experience from a Turkish University Hospital
Authors: Buhur Ali , Unal Omer
Published: March 2023

Background: This study aimed to assess the results of 783 total laparoscopic hysterectomies performed in our clinic for benign reasons. Methods: This study was conducted at a tertiary hospital between January 2017 and December 2020. The results of 783 patients who underwent total laparoscopic hysterectomy for benign indications were evaluated retrospectively, with major and minor complications thoroughly analyzed. Patients’ demographic characteristics were evaluated, including mean age, mean parity, body mass index (BMI), current medical diseases, previous surgeries, hysterectomy indications, operation time, uterus weights, estimated blood loss, and length of hospital stay. The ethics committee of Istanbul Kanuni Sultan Süleyman Training and Research Hospital provided the study’s ethical approval (Approval No. 2021.11.290). SPSS for Windows 24.0 (SPSS Inc., Chicago, IL, USA) was used for statistical analysis, and data were presented as mean, standard deviation, and ratio, with statistical significance set at p < 0.05. Preoperative and postoperative variables were compared using a paired t-test. Results: For the study’s 783 patients, the average age was 50.16 years (range, 33–82), average parity was 3.26 (0–16), and average BMI was 24.37 (21–33) kg/m2. Uterine myoma was the most common reason for hysterectomy in 244 (31.16%) patients, followed by abnormal uterine bleeding in 239 (30.52%) patients. The rate of major complications was 46 (5.8%), and the rate of minor complications was 42 (5.5%). Overall, there were 88 (11.30%) complications. The complication rate and operation indications were comparable to those reported in the literature. Conclusions: Although Laparoscopic hysterectomy is a minimally invasive type of hysterectomy, surgeons should be aware of potential complications during the procedure. Early diagnosis and management of complications reduce morbidity and mortality.
Nanotechnologically Relevant Aspects of COVID-19 Vaccines
Authors: Batley Ryan J. , Chandra Shaneel
Published: March 2023

The COVID-19 pandemic has affected several facets of human existence globally. To counter the spread of the virus, several vaccines have been developed and administered worldwide, using various technologies. Due to the need for the mRNA to be safely ‘protected’ until it can reach the host’s cells, innovative transport, casing, stabilization and attachment mechanisms need to be harnessed to accompany the mRNA. Nanotechnology has featured in several such capacities. Therefore, our short review explores the role of nanomaterials in COVID vaccines, with a core focus on those based on mRNA. Often, the chemistry of these nanomaterials is critical to their success in these, and such important aspects are highlighted in our review. Towards the end, we have also discussed the various vaccine types.
Potential Therapeutic Targets in Ovarian Cancer: Autophagy and Metabolism
Authors: Park Misung , Choe Soohyun , Shin Miyoung , Kim Ayoung , Mo Kyumin , Kwon Hyeonseok , Yoon Hyunho
Published: March 2023

Ovarian cancer (OC) is characterized by high mortality rates owing to late diagnosis and resistance to chemotherapy. Autophagy and metabolism play essential roles in the pathological process of cancer and have recently been proposed as potential targets for anticancer therapies. Autophagy is responsible for the catabolic clearance of functionally misfolded proteins and plays different roles depending on the stage and type of cancer. Thus, understanding and controlling autophagy is relevant for treating cancer. Autophagy intermediates can communicate with each other by providing substrates for glucose, amino acid, and lipid metabolism. Metabolites and metabolic regulatory genes modulate autophagy and influence the immune response. Therefore, autophagy and the functional manipulation of metabolism during starvation or overnutrition are being investigated as potential therapeutic targets. This review discusses the role of autophagy and metabolism in OC and highlights effective therapeutic strategies targeting these processes.
Predictors of Developing Heart Failure in Adults with Congenital Heart Defects
Authors: Norozi Kambiz , Müller Matthias J. , Xing Chuce , Miller Michael R. , Bock Jonas , Paul Thomas , Geyer Siegfried , Dellas Claudia
Published: March 2023

Background: The population of adults with congenital heart defects (ACHD) is growing. The leading cause of premature death in these patients is heart failure (HF). However, there is still limited information on the predictive factors for HF in ACHD patients. Objectives: This study re-examined a group of patients with repaired or palliated congenital heart defects (CHD) that were initially studied in 2003. A follow-up period of 15 years has allowed us to identify and evaluate predictors for the development of HF in ACHD. Methods: All patients with repaired or palliated CHD who participated in the initial study (n = 364) were invited for a follow-up examination. The effects of maximum oxygen uptake (VO2max) during exercise stress testing, the cardiac biomarker N-terminal pro brain natriuretic peptide (NT-proBNP), and QRS complex on the development of HF during the follow-up period were investigated. Results: From May 2017 to April 2019, 249 of the initial 364 (68%) patients participated in the follow-up study. Of these, 21% were found to have mild CHD, 60% had moderate CHD, and 19% had complex CHD. Significant predictors for the development of HF were: NT-proBNP level >1.7 times the upper normal limit, VO2max <73% of predicted values, and QRS complex duration >120 ms. Combination of these three parameters resulted in the highest area-under-the-curve of 0.75, with a sensitivity of 75% and specificity of 63% for predicting the development of HF. Conclusions: In this cohort of ACHD patients, the combination of VO2max%, NT-proBNP, and QRS duration was predictive of HF development over a 15-year follow-up period. Enhanced surveillance of these parameters in patients with ACHD may be beneficial for the prevention of HF and early intervention.
Sex-Specific Thresholds for Cardiac Biomarkers—We Need to Move Forward
Authors: Lobo Ronstan , Jaffe Allan S.
Published: March 2023

Cardiovascular biomarkers play a major diagnostic role for cardiologists. Different biomarkers provide different insights into a variety of cardiovascular conditions and in doing so they improve diagnosis and management. Often, these biomarkers are deployed without carefully evaluating the use of sex-specific cut off values. It is now becoming apparent that the use of such cut off values can improve prognostication and discrimination in some clinical situations. This review paper will focus on the data indicating that there is benefit to the use of sex-specific thresholds. It should be clear that these thresholds will vary depending on the analyte being measured and the specific clinical indication for which the patients are being evaluated; and sex-specific cut off values may be important in some situations but not others. Nonetheless, it is now clear that when evaluating sex-specific cut off values, one often finds benefit. We will highlight these situations using specific cardiac biomarkers as examples.
OCT Guidance in Bifurcation Percutaneous Coronary Intervention
Authors: Moulias Athanasios , Koros Rafail , Papageorgiou Angeliki , Patrinos Panagiotis , Spyropoulou Panagiota , Vakka Angeliki , Bozika Maria , Vasilagkos Georgios , Apostolos Anastasios , Nastouli Kassiani-Maria , Tsigkas Grigorios , Davlouros Periklis
Published: March 2023

Coronary bifurcation is defined by the European Bifurcation Consensus as a coronary artery stenosis adjacent to the origin of a significant side branch. Its anatomy is composed of 3 different segments: proximal main vessel, distal main vessel and side branch. Coronary artery bifurcation lesions are encountered in approximately 15–20% of all percutaneous coronary interventions and constitute a complex subgroup of lesions characterized by lower procedural success rates and higher rates of adverse outcomes. In recent years, a growing focus in the European and Japanese bifurcation club meetings has been the emerging role of intravascular imaging, in guiding successful bifurcation percutaneous coronary interventions (PCI). In this review we will present the main ways optical coherence tomography (OCT) can be used to improve outcomes during bifurcation PCI.
ARTIFICIAL INTELLIGENCE IN METABOLOMIC RESEARCH
Authors: Haykır Hande , Kebiroglu Mehmet Hanifi
Published: March 2023

The term "metabolomics" refers to high-throughput methods for detecting various metabolites and small molecules in biological samples. Undirected metabolomics, also known as unbiased global metabolome analysis, can be used to discover key metabolites as variables or measurements of human health and illness. From this vantage point, it is investigated how artificial intelligence and machine learning enable significant advances in non-targeted metabolic processes as well as significant findings in the early detection and diagnosis of diseases (Jung-Ming G. Lin, et al. 2022). Metabolomics is important for finding cures for many diseases. In the development of innovations in the field of biotechnology, it is of great importance to collect, filter, analyze, and use biological information in smart data. For this reason, many biotechnology companies and various healthcare organizations around the world have created large biological databases. This biological data accelerates the development of products in many areas. Algorithms are being developed for biological data analysis. It is thought that many disease treatments will be found when the human genome is edited. Machine learning techniques are effective tools for metabolomic investigation; however, they can only be used in straightforward computing scenarios. When used functionally, data formatting frequently calls for the use of sub-computational resources that are not covered in this area.
Measuring inner speech objectively and subjectively in aphasia
Authors: Alexander Julianne M , Langland-Hassan Peter , Stark Brielle C
Published: March 2023

BackgroundMany people with aphasia and people without brain injury talk to themselves in their heads, i.e., have “inner speech.” Inner speech may be better than speech out loud for some people with aphasia and may a serve a variety of functions (e.g., emotion regulation), which motivates us to provide a high-fidelity characterization of it. Researchers have used multiple methods to measure this internal phenomenon in the past, which we combine here for the first time in a single study. AimsWe compare performance on inner speech tasks that assess inner speech “in-the-moment” to general subjective impressions of inner speech abilities in individuals with and without aphasia and tease apart the relationship of aphasia severity to inner speech. Methods & ProceduresTwenty people with mild-moderate aphasia and twenty neurotypical controls completed several inner speech tasks, including objective silent rhyme judgements (picture, written, and auditory), subjective reports of inner speech during naming, and subjective rating scales about inner speech experience more generally. Outcomes & ResultsInner speech during silent rhyming tasks was associated with aphasia severity only for more complex tasks (e.g., picture and written rhyming but not auditory rhyming). In-the-moment inner speech reports during silent naming were not associated with aphasia severity, and nor were the subjective ratings about general inner speech experience. Individuals with and without aphasia demonstrated a variety of subjective general inner speech experiences, demonstrating heterogeneity of this phenomenon more broadly. ConclusionsMethods of measuring inner speech complement each other and get at different facets of the inner speech phenomenon, and clinicians and researchers must carefully choose the method(s) that will provide the information about inner speech that they desire.
Corporate governance and business performance of hotels in Western Australia: analysis of market orientation as a mediator
Authors: Kazemian Soheil , Djajadikerta Hadrian Geri , Trireksani Terri , Mohd-Sanusi Zuraidah , Alam Md. Mahmudul
Published: March 2023

Purpose: This study examines whether corporate governance enhances the financial and social business performance of three- to five-star hotels in Western Australia through the three dimensions of market orientation (i.e., customer orientation, competitor orientation, and inter-function coordination) as mediators.Design/methodology/approach: Data were collected from managers of hotels in the WA capital city of Perth and its surrounding areas using a questionnaire. Partial least squares structural equation modelling (PLS-SEM) was used to analyse the data.Findings: The overall result shows interesting findings of market orientation's mediating role. It is found that corporate governance may lead to better financial business performance through competitor orientation, but not through customer orientation and inter-function coordination. Complementary, corporate governance may lead to better social business performance through customer orientation and inter-function coordination, but not through competitor orientation.Originality: This paper offers contributions to both literature and practice on what dimensions of market orientation are important to enhance the performance of hotels when corporate governance is applied.
Experiment ended
Authors: Hong Fei
Published: March 2023

Impact of Decreasing Agricultural Research Funding on Climate Change
Experiment ended
Authors: Hong Fei
Published: March 2023

Impact of Federal Funding on Science
Microcredit as A Strategy for Employment Creation: A Systematic Review of the Literature
Authors: Djihad Tria , Harun Mukaramah , Alam Md. Mahmudul
Published: March 2023

National governments and their development partners have considered microcredit as a strategic tool for vulnerable populations. Easy access to finance increases the client's ability to invest and allows clients to use resources to change their behaviour, increase their business opportunities and create employment. This paper aims to review studies that focused on microcredit and employment issues affecting beneficiaries, including gender-based employment creation and the informal sector. Through a systematic search of electronic databases and keywords to identify relevant studies, 40 core articles are identified for the period 1998-2021. The results indicate the significant impacts of microcredit on women's employment creation and business revenue of microenterprises in the informal sector. Moreover, a few studies set out to integrate gender employment creation and the informal sector with reference to microcredit. A framework is proposed to address the relationship between employment structure and microcredit. Finally, this study recommends developing a financial social accounting matrix and run empirical analysis on macro modelling such as input-output or general equilibrium modelling. Doing so will help obtain better understanding of how microcredit participation is associated with employment creation in different sectors and different types of household groups.
Single Column REE Separation and Radiogenic 143Nd/144Nd Analysis without Sm Elimination
Authors: Dey Bidisha , Shibata Tomoyuki , Yoshikawa Masako
Published: March 2023

A single column separation method has been developed for the determination of radiogenic 143Nd/144Nd ratios for natural geological samples. Conventional radiogenic Nd isotope ratio measurements require rigorous column chemistry involving multiple steps to extract a pure Nd fraction. Elements that cause isobaric interference during analysis are removed using a multi-column separation method, which is often time consuming and/or expensive. In this work, we use a single cation exchange column to extract a Nd fraction, and a novel method of mass fractionation correction to circumvent the isobaric effect of Sm during analysis. The developed method allows accurate measurement of the 143Nd/144Nd ratio without the elimination of Sm. The ratio of two non-radiogenic Nd isotopes with no natural isobars, 145Nd/146Nd, is used to correct for instrumental mass fractionation on 143Nd/146Nd. The corrected 143Nd/146Nd ratios can be converted to the 143Nd/144Nd form using the conventionally used constant ratio of 146Nd/144Nd of 0.721900, allowing direct comparison with published literature and databases. We have implemented this sample preparation scheme to generate accurate and precise radiogenic 143Nd/144Nd ratios for nine natural reference materials including basalts, granites, sediments and sedimentary rocks, confirming the applicability and robustness of this technique.
Asperity-like (segmented) structure of the 6 February 2023 Turkish earthquakes
Authors: Zahradník Jiří , Turhan Fatih , Sokos Efthimios , Gallovič František
Published: March 2023

Key to studies of the rupture process is the identification of its major segmentation into asperities. Common multi-parametric methods invert for a continuous slip distribution; they usually rely on a predefined fault position, nucleation point, planarity, smoothing, etc. Here we propose more flexible low-parametric inversions - multi-point seismic source models, and multi-patch GPS models. We study the recent Mw 7.8 and 7.5 earthquakes in the Eastern-Anatolian fault system, recorded in a high-quality near-regional network of seismic strong motion and GPS stations. Using 40 seismic stations at epicentral distances ~20-300 km, we seek position, time, and DC-constrained mechanism of point-source subevents by a modified iterative deconvolution. We robustly resolve a small number of major asperities and demonstrate bilateral moment release for both earthquakes. Variations of the focal mechanism along the mapped faults are indicated. The inversion of GPS data for finite-fault patches confirms the asperity-like character of the events and validates along-fault changes of the focal mechanism.
Data Matrix Disattenuation: A Simple, Effective Method for Correcting Measurement Error in Multivariate Datasets
Authors: Del Giudice Marco
Published: March 2023

In this note, I describe data matrix disattenuation (DMD), a method for correcting measurement error in multivariate datasets. The method employs a vector of known or estimated reliabilities to disattenuate the correlations among a set of continuous variables, then corrects the data matrix to bring it in agreement with the disattenuated correlation matrix. In doing so, it removes error from the observed scores and can substantially improve their reliability. The effectiveness of the correction increases with the number of variables in the dataset, the strength of their mutual correlations, and the size of the sample. I present initial simulation results on the performance of DMD, and provide an R function for the method. The simplicity, effectiveness, and low computational cost of DMD can make it a convenient error correction tool in many common research settings.
Emotion dysregulation in nonsuicidal self-injury: Dissociations between global self-reports and real-time responses to emotional challenge
Authors: Robinson Kealagh , Karl Johannes Alfons , Cornes Joe Peter , Wilson Marc , Grimshaw Gina M.
Published: March 2023

Introduction: Prominent theories of nonsuicidal self-injury (NSSI) propose that the behaviour is characterised by amplified emotional responses. However, little is known about how people who self-injure respond during emotional challenge. Methods: We measured subjective and physiological responding (heart rate, heart rate variability, and electrodermal responding) among young adults with past-year NSSI (n = 51) and those with no lifetime NSSI (n = 50) during a resting baseline, a stress induction, and a post-stress resting phase. Participants reported the extent to which they spontaneously used cognitive reappraisal and expressive suppression during the post-stress phase. Two weeks later, a subset of the sample (n = 42) reported how they remembered feeling during the laboratory session. Results: Although the NSSI group reported considerably greater emotion dysregulation than Controls, both groups showed similar subjective and psychological reactivity to, and recovery from, emotional challenge. Both groups used reappraisal and suppression regulation strategies following acute stress to a similar extent, and later came to remember the emotional challenge in a similar manner.Limitations: Within the NSSI group, past-year self-injury tended to be infrequent and sporadic. Only 43.6% of the sample participated in the follow-up survey assessing memory of emotional challenge. Conclusions: Findings demonstrate that the role of emotion in NSSI is more complex than prominent theories can account for, raising substantial questions regarding the nature of emotion in NSSI. A more comprehensive understanding of the role of emotion in NSSI is needed to inform intervention strategies to better support people who self-injure.
The Validity of the Czech Version of Body Appreciation Scale-2 for Adolescents
Authors: Kvardová Nikol , Lacko David , Macháčková Hana
Published: March 2023

Background: Understanding the formation of body image is critical for the prevention and treatment of eating disorders, especially in adolescence, when body image develops significantly. One of the important facets of body image is body appreciation, which consists of positive feelings and attitudes towards the body regardless of its perceived “flaws”. To measure body appreciation, Body Appreciation Scale-2 (Tylka & Wood-Barcalow, 2015a), a unidimensional 10-item measure, has been developed and routinely used in body image research. The current study examined the validity (i.e., factor structure, gender and age invariance, associations with other constructs) of the Czech version of Body Appreciation Scale-2 for adolescents.Methods: The study used two large samples of Czech adolescents, aged 13-18 (N1 = 613, M = 15.5, 52% girls; N2 = 1,530, M = 15.4, 50% girls). The data were collected in August 2021 (N1) and November 2020 (N2) through an online survey. For the data analysis, we used confirmatory factor analysis (CFA), multi-group confirmatory factor analysis (MG-CFA), and Structural Equation Modeling (SEM).Results: Our findings supported the proposed unidimensional factor structure and the gender (i.e., girls, boys) and age (i.e., 13-15, 16-18) scalar invariance of the Czech version of Body Appreciation Scale-2. The data also showed the expected positive correlations with body satisfaction and self-esteem, and negative correlations with media-ideal internalization, appearance schematicity, and depression. Furthermore, we discovered that body appreciation was more strongly connected to media-ideal internalization and depression for girls than boys.Conclusions: The present study provided robust evidence that supports the validity of the Czech version of Body Appreciation Scale-2 and its usability for the assessment of body appreciation in Czech adolescents. We also proposed future directions for the research on body appreciation based on the explored gender differences.
Preprint_Inhibitory spillover eating behavior
Authors: Vöhringer Julian Felix , Hütter Mandy , Schroeder Philipp A. , Svaldi Jennifer
Published: March 2023

Overweight and obesity are global problems with negative physical, social, and psychological outcomes. Besides easily accessible food, low physical activity, and automatic responses to food, inhibitory control deficits contribute to weight gain and development of overweight. The inhibitory spillover effect (ISE) improves inhibitory control through transfer of inhibitory control capacity from one domain to an unrelated, second domain. For ISE to occur, one inhibitory control task is executed simultaneously with a second, non-control related task thereby increasing inhibitory control in this task. In this preregistered study, we tested the ISE induced through thought suppression in contrast to a neutral task without enhancement of inhibition in participants with normal weight and overweight (N = 92). A simultaneously conducted bogus taste test served as outcome measure for food intake. We found neither an interaction effect between group affiliation and condition nor an effect of group affiliation on food intake. However, contrary to our expectations, we found higher food intake in participants with active ISE compared to the neutral task. The increased food intake with active ISE might indicate rebound effects of applied thought suppression which led to the experience of loss of control and therefore undermined maintenance and function of the ISE. Furthermore, complexity and length of the administered taste test may have hampered a steady increase of inhibitory control. This main result was robust to all moderator variables of which most were not significant. Covariates “desire to eat snacks” and “state concentration before the taste test” only affected food intake additionally. We elaborate theoretical implications of the present findings, discuss applications of ISE, and future research directions.
Comparative Analysis of Temperature and Solar Radiation Data Available in Mubi-Northeastern Nigeria with Solar Photovoltaic Manufacturer's Standard Test Condition
Authors: Umar Abubakar Saidu
Published: March 2023

In extension to the accelerated growth of the solar photovoltaic industry, the type of solar PV and reliability of solar radiation, temperature and air mass data to adopt at a particularly place has recently caught considerable attention by researchers, manufacturers, investors and consumers. Most solar panels are specified with Standard Test Condition (STC), but not all the locations are in agreement with the standard. These conditions are somehow misleading, as the values of solar radiation, temperature and air mass do not align across the full range of Earth surface. This observation encouraged the author to carryout comparative analysis to figure out whether the temperature and solar radiation data available in Mubi during 2000-2020 years align with that of manufacturer's STC specification or not. A time series analysis was adopted to compare the result obtained with STC values. It was found that the available average temperature was 28.83°C and the direct solar radiation was 3278.93W/m2 in Mubi, which was higher than the STC values. At the same time, the values are capable for harvesting efficient energy, when compared to the respective 25°C and 1000W/m2 of STC specification. The result also recommends poly-crystalline, thin-film or amorphous silicon as most suitable PV modules types to be adopted in Mubi region, because of their less tolerance to high solar radiation and temperature.Energy, Mubi, Radiation, Solar, Temperature