bluuebunny/crossref_metadata_2025 huggingface dataset:
Plagiarism in Predatory Publications: A Comparative Study of Three Nursing Journals
Authors: Owens Jacqueline K. , Nicoll Leslie H.
Published: April 2019

Purpose

This study compared three known predatory nursing journals to determine the percentage of content among them that was plagiarized or duplicated. A serendipitous finding of several instances of plagiarism via duplicate publications during the random analysis of articles in a study examining the quality of articles published in predatory journals prompted this investigation.

Design

The study utilized a descriptive, comparative design. All articles in each journal (n = 296 articles) from inception (volume 1, number 1) through May 1, 2017, were analyzed.

Methods

Each article was evaluated and scored electronically for similarity using an electronic plagiarism detection tool. Articles were then individually reviewed, and exact and near exact matches (90% or greater plagiarized content) were paired. Articles with less than 70% plagiarized scores were randomly sampled, and an in‐depth search for matches of partial content in other journals was conducted. Descriptive statistics were used to summarize the data.

Findings

The extent and direction of duplication from one given journal to another was established. Changes made in subsequent publications, as a potential distraction to identify plagiarism, were also identified. There were 100 (68%) exact and near exact matches in the paired articles. The time lapse between the original and duplicate publication ranged from 0 to 63 months, with a mean of 27.2 months (SD =19.68). Authors were from 26 countries, including Africa, the United States, Turkey, and Iran. Articles with similarity scores in the range of 20% to 70% included possible similarities in content or research plagiarism, but not to the extent of the exact or near exact matches. The majority of the articles (n = 94) went from Journal A or C to Journal B, although four articles were first published in Journal B and then Journal A.

Conclusions

This study found a substantial level of plagiarism via duplicate publications in the three analyzed predatory journals, further diluting credible scientific literature and risking the ability to synthesize evidence accurately to inform practice. Editors should continue to use electronic plagiarism detection tools. Education about publishing misconduct for editors and authors is a high priority.

Clinical Relevance

Both contributors and consumers of nursing literature rely on integrity in publication. Authors expect appropriate credit for their scholarly contributions without unethical and unauthorized duplication of their work. Readers expect current information from original authors, upon which they can make informed practice decisions.
The evaluation of elasticity after nonablative radiofrequency rejuvenation
Authors: Erkiert‐Polguj Anna , Algiert‐Zielinska Barbara , Zdunska Kamila , Markiewicz Agata , Skubalski Janusz , Rotsztejn Helena
Published: April 2019

Background

Laxity and rhytides are manifestations of photodamage on the face and chest. Nonablative radiofrequency (RF) is one of the most common procedures used for skin rejuvenation.

Aim

The aim of this study was to assess the elasticity of face and chest skin after multipolar radiofrequency.

Patients/Methods

Thirty women, aged 43‐68, were included in the study. Twenty women were postmenopausal and 10 were premenopausal. They received 4 treatment sessions with an application of nonablative radiofrequency in 2‐week intervals. Biomechanical properties of the skin were measured with the use of a Cutometer.

Results

The objective evaluation in a cutometric analysis showed a statistically significant improvement between measurements taken in the pretreatment period and 3 months after the treatment.

Conclusions

The study is an objective confirmation that RF treatment improves skin elasticity. The method may appear to be beneficial for women of any age and skin types. It is a noninvasive treatment with a low risk of complications.
Location choice, life cycle and amenities
Authors: Letdin Mariya , Shim Hyoung S.
Published: April 2019

Our study proposes a housing location choice model where a household faces a trade‐off between proximity to place of employment and proximity to amenities. We consider subsamples of high amenity cities and low amenity cities and households with and without children. We show that the roles of gender, education, homeownership, household composition, and public transportation vary significantly depending on level of amenities. Households with a female head of household, those with a working spouse and with older children prefer locating closer to downtown amenities. Female workers with and without children locate closer to work, in high and low amenity cities.
Indocyanine green–assisted dental imaging in the first and second near‐infrared windows as compared with X‐ray imaging
Authors: Li Zhongqiang , Zaid Waleed , Hartzler Thomas , Ramos Alexandra , Osborn Michelle L. , Li Yanping , Yao Shaomian , Xu Jian
Published: April 2019

Indocyanine green (ICG) has been widely used in medical imaging, such as in retinal angiography. Here, we describe a pilot ex vivo study of ICG‐assisted near‐infrared fluorescence (NIRF) dental imaging in the first (700–950 nm for ICG‐NIRF‐I) and second (1000–1700 nm for ICG‐NIRF‐II) NIR windows using human extracted teeth; our study is compared with the traditional prevalent X‐ray imaging and NIR II illumination (NIRi‐II, 1310 nm) without ICG enhancement. The results show that ICG fluorescence has much better imaging contrast in both windows compared with NIRi‐II (by quantitatively comparing NIR intensity of the critical neighboring structures, such as enamel and dentin). Cracked teeth, notoriously hard to diagnose by dental X‐ray and computed tomography, were clearly profiled in NIRF dental imaging. An insidious occlusal caries, missing in X‐ray imaging, became a bright dot that was readily observed in ICG‐NIRF‐I images. For dental decay, NIRF imaging with ICG enhancement could clearly delineate the decay boundary. NIRF in both windows distinguished interproximal and occlusal superficial caries. Overall, ICG‐assisted NIRF dental imaging has unique advantages in identifying cracked teeth and insidious caries. The two NIR imaging windows used in our study might one day serve as noninvasive and nonionizing‐radiation methods for the diagnosis of critical dental diseases in situ.
Unrelated donor hematopoietic stem cell transplantation for pediatric de novo acute myeloid leukemia with intermediate‐ or high‐risk cytogenetics
Authors: Park Eu Gene , Yi Eun Sang , Choi Young Bae , Sung Ki Woong , Koo Hong Hoe , Yoo Keon Hee
Published: April 2019

The role of unrelated donor HSCT for children with de novo AML in CR1 is controversial. We performed this study to investigate the feasibility of unrelated donor HSCT who initially had intermediate‐ or high‐risk cytogenetics. We retrospectively reviewed medical records of patients with AML who received unrelated HSCT in CR1 at Samsung Medical Center between November 2001 and January 2012. Patients were allocated based on karyotype at diagnosis as follows: (a) low‐risk: inv(16), t(16;16), t(8;21), and t(15;17); (b) high‐risk: ‐5, 5q‐, ‐7, 3q abnormalities, t(8;16), t(6;9), t(6;11), t(6;21), t(10;11), complex karyotype (≥3 abnormalities), and acute megakaryocytic leukemia without t(1;22); and (c) IR: all the other karyotypes including normal. Patients in intermediate‐ or high‐risk group who were transplanted with either unrelated CB or matched unrelated BM/mobilized PB in their CR1 were included in this study. The projected OS and EFS rates were 74.9% and 71.1%, respectively, with a median follow‐up of 87.3 months after transplantation. The EFS was 70.1%, 80.7%, and 73.9% for CB, BM, and mobilized PB groups, respectively (P = 0.89), and 73.9% and 70.6% for IR and high‐risk groups (P = 0.76). The leading cause of death was relapse (n = 8), and only one patient died from non‐relapse cause. Unrelated donor HSCT seems a feasible approach for children with intermediate‐ or high‐risk AML in CR1. Relapse remains the leading cause of treatment failure among these patients.
Strong expression of p53 protein in bone marrow samples after hematopoietic stem cell transplantation indicates risk of relapse in pediatric acute lymphoblastic leukemia patients
Authors: Mattsson Kristin , Honkaniemi Emma , Ramme Kim , Barbany Gisela , Sander Birgitta M. , Gustafsson Britt M.
Published: April 2019

Background

For pediatric ALL patients that relapse or respond poorly to conventional chemotherapy treatment, HSCT is one treatment option. Still, relapse occurs in 30% of the children after HSCT. Mutations in the tumor suppressor gene TP53 which can lead to an altered p53 protein expression are rare at time of diagnosis of ALL, yet occur more frequent at relapse indicating a more aggressive disease. Our aim was to evaluate if alterations in the expression of the tumor suppressor protein p53 signaled a relapse in pediatric ALL patients post‐HSCT and could guide for preemptive immunotherapy.

Procedure

Paraffin‐embedded bone marrow samples from 46 children diagnosed with ALL between 1997 and 2010, and transplanted at Karolinska University Hospital, were analyzed for p53 by IHC. Samples were analyzed independently at diagnosis, before HSCT, and after HSCT 0‐3 months, 3‐6 months, and 6‐12 months.

Result

Strong expression of p53 in the bone marrow at 0‐3‐months after HSCT was associated with increased risk of relapse, odds ratio 2.63 (confidence interval 1.08‐6.40) P = 0.033.

Conclusion

Evaluation of p53 protein expression in bone marrow from pediatric ALL patients that undergo HSCT may be a potential, additional prognostic marker for predicting relapse after HSCT.
Does Partisan Bias Modulate Neural Processing of Political Information? An Analysis of the Neural Correlates of Corruption and Positive Messages
Authors: Casado‐Aranda Luis‐Alberto , Venkatraman Vinod , Sánchez‐Fernández Juan , Luque‐Martínez Teodoro
Published: April 2019

Daily worldwide newspapers print articles exposing government corruption. Yet these messages do not lead to a loss of votes for the corrupt parties. Sympathizers’ partisan bias, which respectively minimizes and maximizes corruption and positive messages of their own parties respectively, is widely considered the main cause of the loss of effectiveness of political communications. Despite the well‐established existence of such bias when processing political information, little is known as to its psychological origin. Through the use of neuroscience (fMRI), this study explores the underlying brain mechanisms of negative (corruption) and positive political messages related to a conservative and a socialist Spanish political party, as well as the differences between their sympathizers. The findings reveal that negative (vs. positive) political messages exert the greatest neuroimaging impact on the electorate, as shown in aversive, risk, and disappointment‐related brain regions. Interestingly, we show that there exists a main partisan bias against opposite parties (and not a positive bias toward one’s own party) that stems from a higher risk, ambiguity, and disbelief provoked by both positive and negative information about rival parties. Furthermore, this bias was more pronounced among conservative supporters. The current findings provide valuable insights for political parties to improve their communication campaigns.
Characterization of the novel HLA‐C*07:724 allele by sequencing‐based typing
Authors: Elsermans Vincent , Visentin Jonathan , Top Isabelle , Varlet Pauline , Labalette Myriam
Published: April 2019

HLA‐C*07:724 differs from HLA‐C*07:02:01:01 by one nucleotide substitution in codon 9 in exon 2.
Identification of the novel HLA‐C*12:220 allele in a Chinese individual
Authors: Wang Wei , Wang Fang , You Xuan , He Ji , Zhu Faming
Published: April 2019

The new allele HLA‐C*12:220 differs from HLA‐C*12:03:01:01 by one nucleotide substitution in exon 7.
Endovascular stenting of the superior sagittal sinus to alleviate venous compression caused by a parasagittal meningioma
Authors: Entezami Pouya , Gooch M Reid , Dalfino John
Published: April 2019

Idiopathic intracranial hypertension (IIH) is a challenging disease with unclear pathophysiology. Recognition of venous sinus stenting to improve intracranial pressure is increasing.

We present a 56-year-old man diagnosed with IIH. A parasagittal meningioma abutting the sagittal sinus causing venous compression was found. Venous sinus stenting via endovascular approach using a WALLSTENT was performed. Intravascular pressures recorded after stenting demonstrated resolution of the pressure gradient.

The patient had no complications from the procedure and reported substantial symptomatic improvement. Subsequent ophthalmologic exam demonstrated resolution of the bilateral papilledema noted prior to stenting. Endovascular treatment of venous sinus stenosis in the treatment of IIH is an emerging technique. Treatment of venous compromise due to a mass lesion with stenting is a rarely described concept. For our patient, endovascular stenting was the primary treatment modality, allowing the tumour to be followed with serial imaging.
Gonorrhoea and chlamydia in persons with HIV: number needed to screen
Authors: Tuddenham Susan , Ghanem Khalil G , Gebo Kelly A , Moore Richard D , Mathews William Christopher , Agwu Allison , Mayer Kenneth , Schumacher Christina , Raifman Julia , Berry Stephen A
Published: April 2019

Objectives

Current guidelines recommend screening sexually active persons with HIV (PWH) forNeisseria gonorrhoeae(NG) andChlamydia trachomatis(CT) at least annually. Yet, screening rates in many HIV clinics remain low. In this study, we estimated the number needed to screen (NNS) to detect a NG and/or CT infection at each anatomic site among different subpopulations of PWH. NNS provides a concrete, practical measure to aid in assessing the practical impact of screening.

Methods 

We included adults in care at three HIV Research Network sites in 2011–2014. Restricting to first tests within each year, annual NNS was defined as number of persons tested divided by number positive. We computed urogenital and extragenital NNS by age and risk group (women, men who have sex with women (MSW) and men who have sex with men (MSM)).

Results 

A total of 16 864 NG/CT tests were included. Among patients aged ≤25 years, urogenital NNS was similar among women (15 (95% CI 6 to 71)), MSW (21 (95% CI 6 to 167)) and MSM (20 (95% CI 12 to 36)). Over 25, urogenital NNS increased to a greater extent for women (363 (95% CI 167 to 1000)) and MSW (160 (95% CI 100 to 333)) than MSM (46 (95% CI 38 to 56)). The increase for women versus MSM >25 remained significant (p<0.01) in multivariable analysis. Among MSM, rectal NNS was 5 (95% CI 3 to 7) and 10 (95% CI 9 to 12) for ≤25 and for >25 years and pharyngeal NNS values were 8 (95% CI 5 to 13) and 20 (95% CI 16 to 24).

Conclusions

These findings suggest the importance of regular, at least annual NG/CT screening, particularly extragenital, of HIV positive MSM of all ages. They provide some support for age-based cutoffs for women and MSW (eg, universal screening for those aged ≤25 and targeted screening for those aged >25 years).
A novel fluorescent sensor based on 4-(diethylamino)-2-(hydroxy)-phenyl imine functionalized naphthalimide for highly selective and sensitive detection of CN– and Fe3+
Authors: Zhang You-Ming , Han Bing-Bing , Mao Peng-Peng , Chen Jin-Fa , Yao Hong , Wei Tai-Bao , Lin Qi
Published: April 2019

In this work, a novel sensor molecule HB1, based on a 4-(diethylamino)-2-(hydroxy)-phenyl imine functionalized naphthalimide derivative, was successfully designed and synthesized. Interestingly, the HB1 showed fluorescence identification ability for CN– in DMSO/H2O (8:2, v/v) solution. After addition of CN– into the HB1 solution, the fluorescence intensity of HB1 solution could be enhanced obviously. The anti-disturbance experiments demonstrated that other anions could not interfere in the detection of CN–. On the other hand, HB1 was capable of dual-channel (absorption and fluorescence) detection of Fe3+ in DMSO solution. With the addition of various metal ions into the HB1 solution, only Fe3+ induced the fluorescence emission of HB1 solution quenching and the colour change, and other metal ions could not interfere in the detection of Fe3+. The limits of detection (LODs) of HB1 for CN– and Fe3+ were 6.30 × 10−8 and 3.95 × 10−8 mol/L, respectively. Importantly, the real sample experiment was carried out by detecting CN– in bitter almonds. Additionally, ion test strips based on HB1 were fabricated, which could act as convenient and efficient test kits for detecting CN– and Fe3+.
Bound states of the D-dimensional Schrödinger equation for the generalized Woods–Saxon potential
Authors: Badalov V. H. , Baris B. , Uzun K.
Published: April 2019

The formal framework for quantum mechanics is an infinite number of dimensional space. Hereby, in any analytical calculation of the quantum system, the energy eigenvalues and corresponding wave functions can be represented easily in a finite-dimensional basis set. In this work, the approximate analytical solutions of the hyper-radial Schrödinger equation are obtained for the generalized Wood–Saxon potential by implementing the Pekeris approximation to surmount the centrifugal term. The energy eigenvalues and corresponding hyper-radial wave functions are derived for any angular momentum case by means of state-of-the-art Nikiforov–Uvarov and supersymmetric quantum mechanics methods. Hence, the same expressions are obtained for the energy eigenvalues, and the expression of hyper-radial wave functions transforming each other is shown owing to these methods. Furthermore, a finite number energy spectrum depending on the depths of the potential well [Formula: see text] and [Formula: see text], the radial [Formula: see text] and [Formula: see text] orbital quantum numbers and parameters [Formula: see text], [Formula: see text], [Formula: see text] are also identified in detail. Next, the bound state energies and corresponding normalized hyper-radial wave functions for the neutron system of the [Formula: see text]Fe nucleus are calculated in [Formula: see text] and [Formula: see text] as well as the energy spectrum expressions of other higher dimensions are revealed by using the energy spectrum of [Formula: see text] and [Formula: see text].
Comparison of drift–diffusion model and hydrodynamic carrier transport model for simulation of GaN-based IMPATT diodes
Authors: Li Xiusheng , Yang Lin’an , Ma Xiaohua
Published: April 2019

This paper presents a numerical simulation of a Wurtzite-GaN-based IMPATT diode operating at the low-end frequency of terahertz range. Conventional classical drift–diffusion model is independent of the energy relaxation effect at high electric field. However, in this paper, a hydrodynamic carrier transport model including a new energy-based impact ionization model is used to investigate the dc and high-frequency characteristics of an IMPATT diode with a traditional drift–diffusion model as comparison. Simulation results show that the maximum rf power density and the dc-to-rf conversion efficiency are larger for conventional drift–diffusion model because it overestimates the impact ionization rate. Through hydrodynamic simulation we revealed that the impact ionization rates are seriously affected by the high and rapidly varied electric field and the electron energy relaxation effect, which lead to the rf output power density and the dc-to-rf conversion efficiency falls gradually, and a wider operation frequency band is obtained compared with the drift–diffusion model simulation at frequencies over 310 GHz.
Surgical Repair of the Postoperative Lung Hernia by Combining Mesh Interposition and Chest Wall Stabilization by Using Synthes Plates: A Novel Technique
Authors: Subotic Dragan , Wiese Mark , Hojski Aljaz , Lardinois Didier
Published: April 2019

Several technical points for postoperative lung hernia repair are still not fully elucidated. We present an original technical solution to deal with this complication. In a 68-year-old female, the lung hernia was confirmed 5 months after the partial left-sided chest wall and scapula angle resection with primary Mersilene mesh reconstruction for elastofibroma. The patient refused the proposed surgical correction, being only slightly limited in daily activities. The symptoms persisted under analgetic therapy till the moment when patient’s daily activities became critically limited, 22 months after surgery. The repeated chest CT showed a slight increase in hernia size with no signs of tumour recurrence, so that reoperation was planned. After the exposure of the mesh region, a lung protrusion (4×3 cm) along the anterolateral edge of the mesh was confirmed. By careful dissection, the mesh was separated from a firmly adherent lung and removed. After adhaesiolysis and complete lung liberation, a wedge resection of the afunctional lung tissue of the lingula was done, just in the region of contact with the mesh. After the chest tube insertion, the chest wall defect was reconstructed by using a Mersilene mesh, and the final chest wall stabilization was done by the fixation of two Synthes plates (DePuy Synthes J&J) over the 5th and 6th ribs. The postoperative course was uneventful. One year after the operation, the patient was in good general condition, without the need for analgesics. To the best of our knowledge, the described technique is the original way of dealing with postoperative lung hernia. We find it efficient as a prevention of potential serious hernia-related complications.
Close Relationship between cIAP2 and Human ARDS Induced by Severe H7N9 Infection
Authors: Qin Chu , Sai Xiao-yan , Qian Xiu-fen , Wu Yan , Zou Li-fei , Wang Hong-mei , Bian Tao , Yan Zheng
Published: April 2019

Background. cIAP2 is involved in necroptosis as a key upstream regulation factor. We aimed to investigate the role of cIAP2 in ARDS/ALI induced by H7N9 virus through regulating the RIPK1/3 necroptosis pathway.Methods. Lung tissues of 11 patients who died from ARDS-complicated H7N9 infection between 2013 and 2016 were obtained as the H7N9-ARDS group. Lung tissues near benign lung nodules were acquired as the control group. Histological changes were evaluated by H&E staining. Protein levels of cIAP2, RIPK1, RIPK3, p-RIPK3, MLKL, and p-MLKL in the lung tissues were detected by Western Blot. The mRNA levels of cIAP2, RIPK1, and RIPK3 were detected by real-time PCR.Results. H7N9 virus infection had a high mortality, with ARDS being the leading cause of death. The protein level of cIAP2 in the experimental group was lower than that in the control group (P<0.05). However, the experimental group showed higher RIPK1, RIPK3, and p-RIPK3 protein levels than the control group (P<0.05), as well as the expression level of MLKL and p-MLKL protein, which is a key downstream protein in necroptosis (P<0.05).Conclusion. In tissues from patients with fatal H7N9, downregulation of cIAP2 and induction of necroptosis was observed. We could speculate that necroptosis of the pulmonary epithelium is associated with severe H7N9 infection leading to ARDS. Thus, necroptosis inhibition may be a novel therapy for H7N9 influenza virus.
Spontaneous Splenic Rupture and Rituximab-Induced Acute Thrombocytopenia in a Patient with High-Risk Mantle Cell Lymphoma
Authors: Williams Jared , Chiruka Shingi
Published: April 2019

Mantle cell lymphoma is a relatively rare type of mature B-cell non-Hodgkin’s lymphoma with an incidence of approximately 8 cases per million persons per year. In patients with mantle cell lymphoma, there are rare case reports of the potentially life-threatening consequences of splenic rupture and rituximab-induced acute thrombocytopenia (RIAT) occurring separately, but there are no reports of these occurring in the same patient. Whilst rare, they are important to be aware of as early detection may prevent fatal outcomes.
Resilient Supplier Selection Based on Fuzzy BWM and GMo-RTOPSIS under Supply Chain Environment
Authors: Gan Jiawu , Zhong Shuqi , Liu Sen , Yang Dan
Published: April 2019

Resilient suppliers can reduce supply chain risk, effectively avoid supply chain disruption, and bring profits to enterprises. However, there is no united measuring index system to evaluate the resilient supplier under supply chain environment, and the assessment language sets are usually crisp values. Therefore, in order to fill the research gap, this paper proposes a hybrid method, which combines triangular fuzzy number, the best-worst method (BWM), and the modular TOPSIS in random environments for group decision-making (GMo-RTOPSIS) to solve the above problem. Firstly, the weight of decision-maker is calculated by using fuzzy BWM which can deal with triangular fuzzy numbers. Secondly, triangular fuzzy number is introduced into GMo-RTOPSIS, and combined with fuzzy BWM, alternatives are sorted to select the best resilient supply chain partner. Finally, the feasibility and universality of this method are proved by illustrative examples.
The Effects of Oral Isotretinoin in Women with Acne and Polycystic Ovary Syndrome
Authors: Acmaz G. , Cınar L. , Acmaz B. , Aksoy H. , Kafadar Yusuf Taner , Madendag Y. , Ozdemir F. , Sahin E. , Muderris I.
Published: April 2019

Introduction. Many patients who were diagnosed as polycystic ovary syndrome- (PCOS-) related acne were not capable of sustaining or beginning oral contraceptive pills (OCPs) due to pill scaring, contraindications of OCP use, migraine, or smoking. In this situation, oral isotretinoin treatment may become an important option for PCOS-related acne. The aim of the study was to determine the effects of isotretinoin treatment on PCOS patients who were complicated with severe cystic acne. Materials and Methods. This study consisted of 40 female patients diagnosed as PCOS complicated with severe cystic acne. These patients were not eligible candidates for OCP use due to migraine, thrombophilia, heavy smoking, or pill scare. To establish baseline values of hormone levels, on days 2–5 of the menstrual cycle, venous blood samples were obtained. Moreover Modified Ferriman-Gallwey (mFG) score, acne score (AS), follicle count, and bilateral ovarian volumes were evaluated both before and after isotretinoin treatment. Results. Isotretinoin treatment significantly decreased Ferriman-Gallwey score, free testosterone, insulin level, hemoglobin level, acne score, and ovarian volume. Increased triglyceride and cholesterol levels were detected after treatment. Conclusion. Isotretinoin treatment may have beneficial effects on free testosterone, insulin, acne score, and Ferriman-Gallwey score. Solely isotretinoin administration may supply adequate healing in PCOS patients’ symptoms complicated with severe cystic acne who is not eligible candidates for OCP use. This trial is registered with Clinicaltrials.gov NCT02855138.
Numerical Simulations of Fracture Propagation in Jointed Shale Reservoirs under CO2 Fracturing
Authors: Zhang Qi , Ma Dan , Liu Jiangfeng , Wang Jiehao , Li Xibing , Zhou Zilong
Published: April 2019

Water-based hydraulic fracturing for the exploitation of shale gas reservoirs may be limited by two main factors: (1) water pollution and chemical pollution after the injection process and (2) permeability decrease due to clay mineral swelling upon contact with the injection water. Besides, shale rock nearly always contains fractures and fissures due to geological processes such as deposition and folding. Based on the above, a damage-based coupled model of rock deformation and gas flow is used to simulate the fracturing process in jointed shale wells with CO2 fracturing. We validate our model by comparing the simulation results with theoretical solutions. The research results show that the continuous main fractures are formed along the direction of the maximum principal stress, whilst hydraulic fractures tend to propagate along the preexisting joints due to the lower strength of the joints. The main failure type is tensile damage destruction among these specimens. The preexisting joints can aggravate the damage of the numerical specimens; the seepage areas of the layered jointed sample, vertical jointed sample, and orthogonal jointed sample are increased by 32.5%, 29.16%, and 35.05%, respectively, at time t=39 s compared with the intact sample. The preexisting horizontal joints or vertical joints promote the propagation of hydraulic fractures in the horizontal direction or vertical direction but restrain the expansion of hydraulic fractures in the vertical or horizontal direction.
Squamous Cell Carcinoma Biomarker Sensing on a Strontium Oxide-Modified Interdigitated Electrode Surface for the Diagnosis of Cervical Cancer
Authors: Wang Hongqing , Lakshmipriya Thangavel , Chen Yeng , Gopinath Subash C. B.
Published: April 2019

Cervical cancer is a life-threatening complication, appearing as the uncontrolled growth of abnormal cells in the lining of the cervix. Every year, increasing numbers of cervical cancer cases are reported worldwide. Different identification strategies were proposed to detect cervical cancer at the earlier stages using various biomarkers. Squamous cell carcinoma antigen (SCC-Ag) is one of the potential biomarkers for this diagnosis. Nanomaterial-based detection systems were shown to be efficient with different clinical biomarkers. In this study, we have demonstrated strontium oxide-modified interdigitated electrode (IDE) fabrication by the sol-gel method and characterized by scanning electron microscopy and high-power microscopy. Analysis of the bare devices indicated the reproducibility with the fabrication, and further pH scouting on the device revealed that the reliability of the working pH ranges from 3 to 9. The sensing surface was tested to detect SCC-Ag against its specific antibody; the detection limit was found to be 10 pM, and the sensitivity was in the range between 1 and 10 pM as calculated by 3σ. The specificity experiment was carried out using major proteins from human serum, such as albumin and globulin. SCC-Ag was shown to be selectively detected on the strontium oxide-modified IDE surface.
An Improved Method for Estimating the Domain of Attraction of Passive Biped Walker
Authors: Wang Yu , Cao Heng , Jiang JinLin
Published: April 2019

An indicator of a passive biped walker’s global stability is its domain of attraction, which is usually estimated by the simple cell mapping method. It needs to calculate a large number of cells’ Poincare mapping result in the estimating process. However, the Poincare mapping is usually computationally expensive and time-consuming due to the complex dynamical equation of the passive biped walker. How to estimate the domain of attraction efficiently and reliably is a problem to be solved. Based on the simple cell mapping method, an improved method is proposed to solve it. The proposed method uses the multiple iteration algorithm to calculate a stable domain of attraction and effectively decreases the total number of Poincare mappings. Through the simulation of the simplest passive biped walker, the improved method can obtain the same domain of attraction as that calculated using the simple cell mapping method and reduce calculation time significantly. Furthermore, this improved method not only proposes a way of rapid estimating the domain of attraction, but also provides a feasible tool for selecting the domain of interest and its discretization level.
Prenatal Sacrococcygeal Teratoma Diagnosed in a Fetus with Partial Trisomy 13q22
Authors: Dalal Shana S. , Berry Teresa , Pimentel Veronica Maria
Published: April 2019

Sacrococcygeal teratoma is a rare neoplasm that arises from a totipotent stem cell in Henson’s node. It has rarely been associated with chromosomal abnormalities. We present a unique case of a 25-year-old primigravida at 19 weeks and 5 days of gestation found to have an exophytic complex mass with cystic and solid components in the sacral region. This mass was consistent with a sacrococcygeal teratoma. The patient had originally declined genetic screening. After the ultrasound and genetic counseling, she opted to have cell-free fetal DNA screening that was positive for Trisomy 13. Amniocentesis was performed to confirm the diagnosis. The karyotype demonstrated an abnormality of chromosome 13 and microarray demonstrated a complex structural abnormality of chromosome 13 with large regions of copy number gain. The patient underwent a dilation and evacuation at 23 weeks and 2 days. No fetal autopsy was done. This is a case of a prenatally diagnosed sacrococcygeal teratoma associated with Trisomy 13. It illustrates the diagnostic importance of amniocentesis in setting of fetal anatomical abnormalities on ultrasound. For patients who are reluctant to undergo amniocentesis, cell-free DNA results may provide the additional evidence of the need for diagnostic tests.
Fuzzy Evaluation of Water Quality Based on Micronucleus Technology of Vicia faba Root Tip
Authors: Yang Lingling
Published: April 2019

By establishing a fuzzy mathematical evaluation model based on physical and chemical indicators, this paper investigates the genetic toxic pollution of Chaohu Lake in 2016 through the micronucleus technology of the Vicia faba root tip and evaluates the water quality of Chaohu Lake. The results show that, in recent years, the overall water quality of the lakes around Chaohu has improved slightly, but the pollution levels of some areas (such as Nan Fei He and Shi Wu Li He) are still serious. The results can also provide a more reliable theoretical basis for the planning and management of environment protection.
Research on Automatic Balance Control of Active Magnetic Bearing‐Rigid Rotor System
Authors: Liu Yang , Ming Shuaishuai , Zhao Siyao , Han Jiyuan , Ma Yaxin
Published: April 2019

In this paper, in order to solve the problem of unbalance vibration of rigid rotor system supported by the active magnetic bearing (AMB), automatic balancing method is applied to suppress the unbalance vibration of the rotor system. Firstly, considering the dynamic and static imbalance of the rotor, the detailed dynamic equations of the AMB‐rigid rotor system are established according to Newton’s second law. Then, in order to rotate the rotor around the inertia axis, the notch filter with phase compensation is used to eliminate the synchronous control current. Finally, the variable‐step fourth‐order Runge–Kutta iteration method is used to solve the unbalanced vibration response of the rotor system in MATLAB simulation. The effects of the rotational speed and phase compensation angle on the unbalanced vibration control are analysed in detail. It is found that the synchronous control currents would increase rapidly with the increase of rotational speed if the unbalance vibration cannot be controlled. When the notch filter with phase shift is used to balance the rotor system automatically, the control current is reduced significantly. It avoids the saturation of the power amplifier and reduces the vibration response of the rotor system. The rotor system can be stabilized over the entire operating speed range by adjusting the compensation phase of the notch filter. The method in the paper is easy to implement, and the research result can provide theoretical support for the unbalance vibration control of AMB‐rotor systems.
Mechanics of Lipid Membranes under the Influence of Intramembrane Viscosity
Authors: Kim Chun Il , Liu Zhe
Published: April 2019

We discuss a continuum‐based model describing the deformations of lipid membranes subjected to intramembrane viscosity. Within the frame work of the theory of an elastic surface, the membrane equilibrium equations and the expressions of viscous stress are obtained. The corresponding deformation energy of the membrane is computed via the first and second fundamental form of surface. A compatible linear model is also formulated within the prescription of superposed incremental deformations through which the deformation profiles of the membrane is obtained. It is shown that the intramembrane viscous flow gives rise to straining effects on the membranes. Further, the corresponding dynamic edge conditions reduce to purely elastic boundary conditions in the limit of vanishing viscous effects. Lastly, admissible sets of velocity fields are also examined and are used to formulate membrane shape equations and the associated dynamic boundary conditions.
Metabolomics Analysis in Serum from Patients with Colorectal Polyp and Colorectal Cancer by 1H-NMR Spectrometry
Authors: Gu Jinping , Xiao Yaqing , Shu Dan , Liang Xianrui , Hu Xiaomin , Xie Yuanyuan , Lin Donghai , Li Hua
Published: April 2019

Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Colorectal adenomatous polyps are at high risk for the development of CRC. In this report, we described the metabolic changes in the sera from patients with colorectal polyps and CRC by using the NMR-based metabolomics. 110 serum samples were collected from patients and healthy controls, including 40 CRC patients, 32 colorectal polyp patients, and 38 healthy controls. The metabolic profiles and differential metabolites of sera were analyzed by multivariate statistical analysis (MSA), including principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), and orthogonal partial least squares discriminant analysis (OPLS-DA) methods. A total of 23 differential metabolites were identified from MSA. According to the pathway analysis and multivariate ROC curve-based exploratory analysis by using the relative concentrations of differential metabolites, we found abnormal metabolic pathways and potential biomarkers involved with the colorectal polyp and CRC. The results showed that the pyruvate metabolism and glycerolipid metabolism were activated in colorectal polyps. And the glycolysis and glycine, serine, and threonine metabolism were activated in CRC. The changed metabolism may promote cellular proliferation. In addition, we found that the rates of acetate/glycerol and lactate/citrate could be the potential biomarkers in colorectal polyp and CRC, respectively. The application of 1H-NMR metabolomics analysis in serum has interesting potential as a new detection and diagnostic tool for early diagnosis of CRC.
Over the Counter Sale of Antibiotics at Drug Stores Found in Mizan-Aman Town, Southwest Ethiopia: A Cross-Sectional Simulated Client Visit Study
Authors: Damisie Getahun , Hambisa Solomon , Yimam Mohammed
Published: April 2019

Background. Antibiotics are crucial drugs, particularly in the developing world, where infectious diseases are a common cause of death. Misuse and overuse of antibiotics have driven the emergency of antibiotic-resistant bacteria, which in turn leads to a loss of efficacy of these drugs. This study aimed to assess the professional practice on OTC sale of antibiotics at community drug retail outlets found in Mizan-Aman town. Methods. A cross-sectional simulated client visit study was conducted among community drug retail outlets found in Mizan-Aman town, Southwest Ethiopia, from 14 to 28 March, 2018. Currently, there are 18 commercially licensed community drug retail outlets in Mizan-Aman town and the study was undertaken on all drug retail outlets. Each drug retail outlet was visited once by investigators who simulated inflicting clinical scenario according to simulated client method pharmacy surveys. Three different clinical scenarios were chosen and, in each of the three cases, three levels of demand were used to obtain the antibiotic. The findings of the study were entered, cleared, coded, and stored into Epi Info version 3.5.1 and exported to Statistical Package for Social Sciences (Windows version 21) and the collected data were compiled and presented as descriptive statistics using tables and figures. Results. Most, 17 (94.4%), of drug stores out of the total 18 in which all three clinical scenarios were allotted were issued antibiotics without a need of medical prescription with three different levels of demands. Antibiotics were sold without a prescription in most (94.4%) of drug stores in which a urinary tract infection clinical scenario was presented. Similarly, antibiotics were obtained without a prescription for acute diarrhea from 16 (88.9%) drug stores. With respect to sore throat simulation, antimicrobial drugs were obtained without a prescription from 14 (77.8%) drug stores. Commonly dispensed antibiotics were Metronidazole (50.0%), Ciprofloxacin (38.9%), and Amoxicillin (71.4%) for acute diarrhea, urinary tract infection, and sore throat case scenarios, respectively. Only 1 drug store (5.5%) refused to dispense any kind of antibiotics. Conclusion. The results of this study demonstrate that nonprescription sales of antibiotics were highly pronounced in contrary to national guidelines regarding this practice. Most of antibiotics were dispensed without a prescription when the simulator asked any medication to alleviate his/her symptoms.
Evaluating Risks of Mergers & Acquisitions by Grey Relational Analysis Based on Interval‐Valued Intuitionistic Fuzzy Information
Authors: Hongjiu Liu , Qingyang Liu , Yanrong Hu
Published: April 2019

Purpose. The purpose of our research is to explore a new grey relational analysis method when information of decision making is interval‐valued, intuitionistic, fuzzy, and uncertain in risk analysis of Mergers & Acquisitions. Design/Methodology/Approach. We proposed a new method to evaluate risks of Mergers & Acquisitions. The process of our method is to determine the positive and negative ideal solutions of interval‐valued intuitional fuzzy uncertain language firstly. Then, calculate grey relational grades of every evaluating value for positive or negative ideal solutions. Third, determine the weights of attributes by a linear programming model if part of attribute information is known. Fourth, calculate grey relational grades of each alternative for the positive or negative ideal solutions. Lastly, calculate relative grey relational grades and sort the alternatives. Findings. Our case analysis demonstrated that the new grey relational analysis is an effective tool to evaluate the risks of Mergers & Acquisition when information of decision making is interval‐valued, intuitionistic, fuzzy, and uncertain. At the same time, we also bring forward the steps of evaluation. Originality/Value. Because risks of Mergers & Acquisitions decide its success or failure to some extent, it is very important to evaluate them by feasible and available method. However, the information of risks is fuzzy and uncertain usually. The new grey relational analysis based on Interval‐Valued Intuitionistic Fuzzy Information does not only evaluate risks of Mergers & Acquisitions but also can be widely applied to similar problems of decision making in other fields.
Desmoplastic Melanoma Arising after 1,064 nm q-Switched Nd:YAG Laser of a Suspected Solar Lentigo
Authors: Cohen Leah , Nanda Sonali , Zaiac Martin
Published: April 2019

Objectives. To present a case of desmoplastic melanoma (DM) arising after laser therapy of a suspected solar lentigo with the 1,064 nm Q-switched (QS) Neodymium:Yttrium-Aluminum-Garnet (Nd:YAG) laser and discuss the safety of treating suspected solar lentigines with laser therapy.Methods. Case presentation with discussion.Results. We describe a patient who developed DM after 1,064 nm QS Nd:YAG laser therapy to a suspected solar lentigo.Conclusions. Limited generalizable studies regarding the safety of laser therapy for solar lentigines exist, specifically for the 1,064 nm QS Nd:YAG laser. Therefore, we recommend caution is taken when considering laser therapy for these lesions, as well as strong consideration for histologic confirmation prior to therapy.
Severe Disabling Myalgia as an Initial Presentation of Polyarteritis Nodosa
Authors: Senarathna H. M. , Fonseka C. L. , Perera H. A. S. , De Silva P. U. T. , Weerarathna T. P.
Published: April 2019

Background. Polyarteritis nodosa (PAN) is a form of necrotizing vasculitis affecting medium or small blood vessels with multiorgan involvement. Although myalgia is a clinical feature of PAN, severe disabling myalgia as the initial presentation is rarely noted. Case Presentation. We present a case of 54-year-old male with recently detected chronic kidney disease admitted with progressive severe disabling muscular pains predominantly over calves with constitutional symptoms for seven weeks. He was weak to mobilize out of the bed. Later, he developed a vasculitic rash, unilateral ulnar claw, and bilateral foot drop. His skin and muscle biopsies showed evidence of vasculitis. His renal and mesenteric artery CT angiogram revealed stenosed segment of the celiac artery without evidence of visible aneurysms elsewhere. He completed six cycles of intravenous cyclophosphamide pulse therapy with high-dose oral prednisolone with good response. With continuation of aggressive immunosuppression and rehabilitation for five months, the patient improved and was able to walk without support. Conclusion. Musculoskeletal predominant PAN, even though rare, needs to be considered in patients presenting with disabling muscle pain and weakness. These features may herald over days to months along with constitutional symptoms before other systems getting affected. Early recognition of such symptoms and initiating specific treatment would be important for better outcomes.
Eradication of HCV Infection with the Direct-Acting Antiviral Therapy in Renal Allograft Recipients
Authors: Calogero Armando , Sagnelli Evangelista , Creta Massimiliano , Angeletti Silvia , Peluso Gaia , Incollingo Paola , Candida Maria , Minieri Gianluca , Carlomagno Nicola , Dodaro Concetta Anna , Ciccozzi Massimo , Sagnelli Caterina
Published: April 2019

Hepatitis C virus (HCV) infection unfavorably affects the survival of both renal patients undergoing hemodialysis and renal transplant recipients. In this subset of patients, the effectiveness and safety of different combinations of interferon-free direct-acting antiviral agents (DAAs) have been analyzed in several small studies. Despite fragmentary, the available data demonstrate that DAA treatment is safe and effective in eradicating HCV infection, with a sustained virologic response (SVR) rates nearly 95% and without an increased risk of allograft rejection. This review article analyzes the results of most published studies on this topic to favor more in-depth knowledge of the readers on the subject. We suggest, however, perseverating in this update as the optimal DAA regimen may not be proposed yet, because of the expected arrival of newer DAAs and of the lack of data from large multicenter randomized controlled trials.
Ventricular Arrhythmia Precipitated by Severe Hypocalcaemia Secondary to Primary Hypoparathyroidism
Authors: Ashwin Reddy S.
Published: April 2019

Hypocalcaemia causes neuromuscular and myocardial symptoms, including QT interval prolongation, and cardiac arrhythmias. Prompt detection and calcium replacement may reverse the pathology, following which the underlying cause should be diagnosed and treated to prevent recurrence. I present the case of a young man presenting with collapse who was found to have sinus rhythm with significant QT interval prolongation on admission electrocardiogram (ECG) associated with profound hypocalcaemia secondary to primary hypoparathyroidism.