bluuebunny/crossref_metadata_2025 huggingface dataset:
Real-World Data (RWD) on the 3-Year Follow-Up Outcomes of Different CNS Prophylaxis Strategies Across CNS-IPI Risk Groups in Patients With Diffuse Large B-Cell Non-Hodgkin Lymphoma
Authors: Faqah Anadil , Asif Summaiya , Goksu Suleyman Yasin , Sheikh Hassan S.
Published: April 2021

PURPOSE

CNS relapse in patients with diffuse large B-cell lymphoma (DLBCL) is associated with poor prognosis with a median survival of about 2.5 months. Data demonstrating best prophylactic strategy remain controversial and need further definition.

PATIENTS AND METHODS

We present data of 110 patients with DLBCL treated with standard systemic therapy divided into four groups based on primary CNS prophylaxis strategy and CNS International Prognostic Index (IPI) risk categories. We compared their 3-year CNS relapse rate and overall survival in each group.

RESULTS

The CNS prophylaxis strategy consisted of intrathecal (IT) methotrexate (MTX) in group 1, high-dose (HD) MTX in group 2, combination IT and HD MTX in group 3, and IT and/or HD MTX with intensive chemotherapy in group 4. At 3 years, CNS relapse rate was 8.6% (4/46), 8.3% (1/12), 4.8% (2/42), and 18% (2/11) in groups 1-4 ( P = .64), respectively. According to CNS IPI, the CNS relapse rate was 16.6%, 10.1%, and 0% in high-, intermediate-, and low-risk groups, respectively. The 3-year overall survival rate was 69%, 75%, 80%, and 45% in groups 1-4 ( P = .71), respectively.

CONCLUSION

Our study while did not find statistical significance did indicate a lower incidence of CNS relapse with the addition of systemic HD MTX to IT MTX in the high-risk DLBCL population.
Mindfulness Among Medical Oncology Doctors and Its Relation With Burnout: Turkish Oncology Group (TOG) Study
Authors: Avcı Okan , İriağaç Yakup , Çavdar Eyyüp , Şeber Erdoğan Selçuk
Published: April 2021

PURPOSE:

Medical oncology physicians have been identified as one of the main risk groups for the development of burnout. Mindfulness as being aware of the moment nonjudgmentally seems to be a protective factor against burnout. We aimed to reveal mindfulness levels among medical oncology doctors and the potential impact of mindfulness on burnout syndrome.

METHODS:

In this cross-sectional study, the data of 285 medical oncology doctors were analyzed. The Mindful Attention Awareness Scale was used for mindfulness evaluation, and the Maslach Burnout Inventory was used for burnout assessment. After defining mindfulness levels among medical oncology doctors, the relationship between mindfulness and burnout was analyzed by the Pearson correlation and bivariate logistic regression tests.

RESULTS:

The mean Mindful Attention Awareness Scale score of participants was 54.52 ± 13.77. Mindfulness was associated with age ( P < .001), having a hobby ( P = .008), regular exercise ( P = .001), professional title ( P = .02), and professional experience ( P = .02). As the level of mindfulness increased, emotional exhaustion and depersonalization decreased, whereas personal accomplishment increased significantly (all P < .001). In the regression analysis, mindfulness was significantly associated with all three subscales of burnout (all P < .01).

CONCLUSION:

We have demonstrated for the first time on such a large scale that higher levels of mindfulness were related with lower burnout among medical oncology physicians. These findings suggest the potential benefits of mindfulness-based interventions in reducing burnout levels in medical oncologists.
Zigzag instability of biased pusher swimmers
Authors: Lauga Eric , Nghi Dang Thanh , Ishikawa Takuji
Published: April 2021

Microorganisms self-propelling in a fluid create flow fields that impact the dynamics of other swimmers. Some organisms can be biased and have a preferred swimming direction, e.g., those displaying gyrotaxis, chemotaxis or phototaxis, and as a result often focus along thin lines. Here we use numerical computations and far-field theoretical calculations to show that the position of a collection of biased swimmers moving along a line is unstable to a zigzag mode when the swimmers act on the fluid as pusher dipoles. This instability takes the form of periodic transverse oscillations in the position of the swimmers. We predict theoretically that the most unstable wavelength is equal to twice the inter-swimmer distance and that the growth rate of the instability increases linearly with the magnitude of the stresslet, both of which are in quantitative agreement with our numerical simulations.
The Long Arm of Conflict: How Timing Shapes the Impact of Childhood Exposure to War
Authors: Ramirez Daniel , Haas Steven A.
Published: April 2021

This paper examines how the timing of childhood exposure to armed conflict influences both the magnitude of the impact it has on later-life health and the pathways through which those impacts manifest. Utilizing the Survey of Health and Retirement in Europe, we examine cohorts of children during World War II. We find that cohorts born during the war show the largest negative effects of exposure on health in later life. The pathways also vary the timing of exposure. Consistent with a latent critical period process, children born during the war experienced increased risk of poor health and illness in childhood, as well as adult cardiometabolic conditions and poor functional health. Conversely, cohorts born before the war experienced more indirect pathways consistent with cumulative disadvantage processes and institutional breakdown. These pathways include stunted socioeconomic attainment, increased risk behaviors, and poorer mental health. Overall, this study emphasizes that the timing of exposure is critical to understanding the long-term health effects of war.
Design and Synthesis of Paraphenylene-derived Figure-of-eight Rigid Macrocycles
Authors: Cong Huan
Published: April 2021

Macrocycles are essential building blocks for supramolecular architectures. In this Highlight Review, recent progress in our laboratory is summarized regarding the development of paraphenylene-derived figure-of-eight rigid macrocycles. These molecules are derived from X-shaped cores including anthracene photodimer, tetraphenylethylene, and copper-phenanthroline complex, and exhibit attractive topological or fluorescent properties.
Role of Perivascular Adipose Tissue and Exercise on Arterial Function with Obesity
Authors: Boateng Samuel Y. , Olfert I. Mark , Chantler Paul D.
Published: April 2021

Adipose tissue and arterial dysfunction are common in the obese state. Perivascular adipose tissue (PVAT) plays an important role in mediating arterial health, and with obesity, the PVAT dysfunction negatively affects arterial health. Exercise training exerts direct and beneficial effects on PVAT, providing an additional and novel pathway by which exercise can improve arterial health in diseased populations.
Physical Activity, Menstrual History, and Bone Microarchitecture in Female Athletes with Multiple Bone Stress Injuries
Authors: RUDOLPH SARA E. , CAKSA SIGNE , GEHMAN SARAH , GARRAHAN MARGARET , HUGHES JULIE M. , TENFORDE ADAM S. , ACKERMAN KATHRYN E. , BOUXSEIN MARY L. , POPP KRISTIN L.
Published: April 2021

Bone stress injuries (BSI) occur in up to 20% of runners and military recruits and those with a history of BSI have a fivefold higher risk for a subsequent BSI. Yet, little is known about prior training, menstrual status, and bone structure in runners who experience multiple BSI.

Purpose

To determine differences in health and physical activity history, bone density, microarchitecture, and strength among female athletes with a history of multiple BSI, athletes with ≤1 BSI, and nonathletes.

Methods

We enrolled 101 women (age, 18–32 yr) for this cross-sectional study: nonathlete controls (n = 17) and athletes with a history of ≥3 BSIs (n = 21) or ≤1 BSI (n = 63). We collected subjects’ health and training history and measured bone microarchitecture of the distal tibia via high-resolution peripheral quantitative computed tomography (HR-pQCT) and areal bone mineral density of the hip and spine by dual-energy X-ray absorptiometry.

Results

Groups did not differ according to age, body mass index, age at menarche, areal bone mineral density, or tibial bone microarchitecture. Women with multiple BSI had a higher prevalence of primary and secondary amenorrhea (P < 0.01) compared with other groups. Total hours of physical activity in middle school were similar across groups; however, women with multiple BSI performed more total hours of physical activity in high school (P = 0.05), more hours of uniaxial loading in both middle school and high school (P = 0.004, P = 0.02), and a smaller proportion of multiaxial loading activity compared with other groups.

Conclusions

These observations suggest that participation in sports with multiaxial loading and maintaining normal menstrual status during adolescence and young adulthood may reduce the risk of multiple bone stress injuries.
Neuromuscular Correlates of the Contralateral Stretch-induced Strength Loss
Authors: CORATELLA GIUSEPPE , CÈ EMILIANO , DORIA CHRISTIAN , BORRELLI MARTA , LONGO STEFANO , ESPOSITO FABIO
Published: April 2021

Purpose

The current study investigated the effects of unilateral passive stretching on the neuromuscular mechanisms involved in the force-generating capacity of the contralateral muscle.

Methods

Twenty-six healthy men underwent unilateral passive stretching of the plantarflexors (5 × 45 s on + 15 s off; total stretching time, 225 s). Before and after the stretching protocol, contralateral ankle range of motion, maximum voluntary contraction (MVC) of the plantarflexors, and surface electromyographic root-mean-square (sEMG RMS) of the soleus and the gastrocnemii muscles were determined. Concurrently, V-wave, maximum and superimposed H-reflex, and M-wave were elicited via nerve stimulation to estimate the supraspinal, spinal, and peripheral mechanisms, respectively. sEMG RMS, V-wave, and H-reflex were normalized to the M-wave.

Results

After passive stretching, contralateral ankle range of motion was increased (+8% [1%/15%], effect size [ES] = 0.43 [0.02/0.84], P < 0.001), MVC of the plantarflexors was decreased (−9% [−21%/−2%], ES = −0.96 [−1.53/−0.38], P < 0.001), and the sEMG RMS/M-wave of the soleus and the gastrocnemii muscles was decreased (≈−9%, ES ≈ −0.33, P < 0.05). Concurrently, the V-wave/M-wave superimposed was decreased in all muscles (≈−13%, ES = −0.81 to −0.52, P < 0.05). No change in H-reflex/M-wave and M-wave was observed under both maximum and superimposed condition. The decrease in the MVC and the sEMG RMS of the contralateral muscle was accompanied by a decrease in the V-wave/M-wave but not the H-reflex/M-wave ratios and the M-wave.

Conclusions

The present outcomes suggest that only supraspinal mechanisms might be involved in the contralateral decrease in the maximum force-generating capacity.
Re-initiation of CT colonography services during the COVID-19 pandemic: Preliminary evaluation of safety
Authors: Peprah David , Plumb Andrew , Corr Alison , Muckian Janice , Smith Kathryn , Sergot Antoni , Kuah Jia Ying , Stephenson James
Published: April 2021

Objective:

The COVID-19 pandemic has led to cancellation and deferral of many cancer investigations, including CT colonography (CTC). In May 2020, BSGAR and SCoR issued guidelines outlining steps for conduct of CTC in the early recovery phase. We evaluated the implementation of these in four English hospital trusts.

Methods:

Ethical permission was not required for this multicentre service evaluation. We identified patients undergoing CTC over a 2-month period from May to July 2020 at four Trusts. We recorded demographics, scan indications, colonic findings, and incidental lung base changes compatible with COVID-19. A subset of patients were contacted via telephone to document new symptoms 2 weeks following their scan. Staff were contacted to determine if any acquired COVID-19 during the period.

Results:

224 patients (118 male, 52.7%) were scanned during the period. In 55 patients (24.6%), CTC showed a ≥6 mm polyp. 33 of 224 (14.7%) scans showed incidental lung base changes felt unrelated to COVID-19, and only one patient had changes indeterminate for COVID-19; no classic COVID-19 pulmonary changes were found. Of 169 patients with telephone follow-up, none reported any new symptoms of COVID-19 (cough, fever, anosmia, ageusia) within 14 days of CTC. None of the 86 staff contacted developed COVID-19.

Conclusion:

We found no cases of patients or staff acquiring COVID-19 infection following CTC; and no evidence of significant asymptomatic COVID-19 patients attending for CTC appointments based on lung base changes.

Advances in knowledge:

Our findings suggest that current practice is unlikely to contribute significantly to spread of SARS-nCOV2. Cancer and significant polyp detection rates were high, underlining the importance of maintaining service provision.
MRI features of different types of sinonasan rhabdomyosarcomas: a series of eleven cases
Authors: Zeng Junjie , Liu Lan , Li Jiayong , Huang Qiling , Pi Leiming , Jin Ke
Published: April 2021

Objective:

To retrospectively analyze magnetic resonance imaging (MRI) features of various pathological subtypes of sinonasal rhabdomyosarcoma (RMS) and explore correlations between imaging features and pathological subtypes.

Methods:

In total, 11 cases with embryonal, alveolar or pleomorphic sinonasal RMSs, confirmed by surgical pathology, were selected. Their characteristics and distinctive imaging features were analysed, and the correlation between pathology and imaging features was explored.

Results:

Bone destruction was observed in all 11 cases with RMS. Expansive growth was predominant in three alveolar and three embryonal RMS cases, and creeping growth was predominant in two alveolar, two embryonal and one pleomorphic RMS cases. Signs of residual mucosa were observed in all 11 cases, and 10 cases showed involvement of multiple sinus cavities and orbital cavities. All cases exhibited mild-to-intermediate enhancement.

Conclusion:

Sinonasal RMSs have the following characteristic MRI features: ethmoid sinuses and middle nasal conchae are the prevalent sites; lesions are mainly of mild enhancement; tumours exhibit signs of residual mucosa, mild-to-intermediate enhancement and frequent orbital involvement; bone invasion and bone destruction are frequently observed; and haematogenous metastasis is not as common as lymphatic metastasis. RMSs of various pathological subtypes were not significantly distinct by imaging.
Vom Befund zum Lebensbild
Authors: Asal Markus
Published: April 2021

Seit dem ausgehenden 19. Jahrhundert geben Ausgrabungen den Archäologinnen und Archäologen immer wieder Einblicke in die bis zu drei Meter mächtigen Siedlungsablagerungen unter dem Asphalt des Münsterhügels. Zahlreich sind dabei die Befunde und Funde, die der Spätantike (ausgehendes 3. bis etwa zur Mitte des 5. Jahrhunderts) zugewiesen können.

Dank moderner computergestützten Grafikprogramme besteht heute die technische Möglichkeit, die archäologischen Erkenntnisse in Lebensbildern zu visualisieren. In diesem Beitrag wird anhand ausgewählter Beispiele aufgezeigt, wie das neue Lebensbild des spätrömischen Basels entstand.
Barreras de entrada en la cadena global de valor de agrobiotecnología en semillas: caso Argentina
Authors: Calvo Santiago Andrés
Published: April 2021

Las relaciones económicas internacionales asistieron a un complejo proceso de producciónde bienes y servicios geográficamente fragmentados y articulados entre sí. Frente a ello, la perspectiva de cadena global de valor destaca el rol predominante de las empresas trasnacionales, así como sus capacidades para restringir la participación de nuevos actores. Entre los paradigmas tecnoproductivos emergentes, se encuentra la biotecnología en semillas. Testigo de una continua concentración empresarial, expresa cabalmente las restricciones impuestas por un reducido grupo de multinacionales. En efecto, el presente trabajo busca explicitar las barreras que enfrentan los actores de Argentina para participar en los eslabones de alto valor agregado a partir de un análisis de la cadena global de valor del sector agrobiotecnológico en semillas.
Product Choice with Large Assortments: A Scalable Deep-Learning Model
Authors: Gabel Sebastian , Timoshenko Artem
Published: April 2021

Personalized marketing in retail requires a model to predict how different marketing actions affect product choices by individual customers. Large retailers often handle millions of transactions daily, involving thousands of products in hundreds of categories. Product choice models thus need to scale to large product assortments and customer bases, without extensive product attribute information. To address these challenges, we propose a custom deep neural network model. The model incorporates bottleneck layers to encode cross-product relationships, calibrates time-series filters to capture purchase dynamics for products with different interpurchase times, and relies on weight sharing between the products to improve convergence and scale to large assortments. The model applies to loyalty card transaction data without predefined categories or product attributes to predict customer-specific purchase probabilities in response to marketing actions. In a simulation, the proposed product choice model predicts purchase decisions better than baseline methods by adjusting the predicted probabilities for the effects of recent purchases and price discounts. The improved predictions lead to substantially higher revenue gains in a simulated coupon personalization problem. We verify predictive performance using transaction data from a large retailer with experimental variation in price discounts.

This paper was accepted by Gui Liberali, Management Science Special Section on Data-Driven Prescriptive Analytics.
Taxing the Taxpayers: An Empirical Investigation of the Drivers of Baseline Changes in U.S. Federal Government Technology Programs
Authors: Roy Dwaipayan , Mishra Anant , Sinha Kingshuk K.
Published: April 2021

Problem definition: The U.S. federal government makes significant investments in technology programs to deliver essential services to the public. The execution of a program is monitored against a baseline—an aggregate plan representing the program’s planned budget, schedule and scope. Recent reports suggest that federal technology programs are re-baselined multiple times, resulting in additional spending of taxpayer money. Although a program’s scope has often been considered a driver of baseline changes, we have a limited understanding of the execution factors that may affect this relationship. Academic/Practical Relevance: With increasing bipartisan scrutiny of federal spending in technology programs and continuing debate in the media about their execution, a nuanced understanding of the drivers of baseline changes in federal technology programs is a critical and contemporary line of inquiry relevant to both policymakers and managers. Our study also responds to recent calls in the operations management literature for research on public sector operations. Methodology: The study sample comprises detailed archival data on 240 U.S. federal government technology programs across 24 federal agencies. We estimate a negative binomial regression specification that accounts for agency fixed effects and several program-specific characteristics to test four hypotheses on the interrelationships between a program’s scope, granularity, management competency, execution methodology and baseline changes.. Results: The results indicate that program scope is positively associated with the number of baseline changes. However, increasing levels of program granularity and program management competency attenuate this positive relationship. Additional analysis highlights the significant savings in taxpayer contributions that can occur by reducing baseline changes in programs of greater scope through an increase in the levels of program granularity and program management competency. Managerial Implications: The study results emphasize the need for federal agencies to invest greater efforts in granularizing a program and in identifying managers with high levels of program management competency when program scope is high, as such efforts can translate into a reduction in the number of baseline changes. The results also highlight the role of number of baseline changes as a valuable in-process metric for program managers and federal agencies to monitor the execution of federal technology programs and identify programs with greater potential. for experiencing cost overruns.
Anti-Diabetic and Hypolipidemic Effect of Coccinia Indica in Glucocorticoid Induced Insulin Resistance
Authors: Koyagura Narendar , Kumar V. Hemanth , Shanmugam Chandrakumar
Published: April 2021

This study explores the anti-diabetic, insulin sensitizing and hypolipidemic activity of Coccinia indica (C.indica) leaf extract (ethanolic) in glucocorticoid induced insulin resistance (IR). A 12 day study with 5 groups of 30 male Wistar albino rats, with 6 rats in each was conducted. The rats in all the groups except group 1 received dexamethasone (8mg/kg/i.p.) from 7th to 12th day to induce IR. The groups 1 and 2 received 2% gum acacia orally for 12 days whereas the groups 3 & 4 received oral ethanolic extract of C.indica leaf in the dose of 1 and 2 gm/kg, respectively. The standard control (group 5) received metformin (1gm/kg) orally for 12 days. Fasting serum glucose, insulin and lipid levels were estimated at the beginning and end of the study. The insulin sensitivity indices (homeostatic model assessment of insulin resistance and sensitivity, fasting glucose to insulin ratio, hepatic & atherogenic indices) were calculated. The body weight was monitored on alternate days. The liver weight, volume and histopathology were also done. Compared to group 2 rats, the group’s 3 & 4 demonstrated significant(p<0.05) dose dependent lowering of serum glucose, insulin and lipids as well as lowered IR, improved insulin sensitivity and reduced hepatic steatosis. Additionally, group 2 rats had low body weight and hepatomegaly. This extract demonstrated significant anti-diabetic, hypolipidemic and insulin sensitizing activity. Hence it can be used as an effective alternative for treating type2 diabetes mellitus.
Ethanol Extract of Young Papaya Seeds (Carica Papaya, L ) Lower the Level of testosterone, Spermatozoa Count and Expression of Androgen Receptors in Sertoli Cells of Adult Mice (Mus Musculus)
Authors: Ruspawan I Dewa Made , Bakta I Made , Mangku Karmaya I Nyoman , Komang Satriyasa Bagus , Nyoman Arijana I Gusti Kamasan
Published: April 2021

Background: Ethanol extract of young papaya seeds (Carica papaya L.) contains steroids that thought to has the antifertility property. This study aims to prove this hypothesis by measuring the low levels of testosterone hormone, spermatozoa count, and androgen receptor expression in sertoli cells. Material and Method:We use the randomized post-test only control group design on thirty-six male Balb/c strain adult male mice aged 12-14 weeks, weight 20-25 grams. They were randomly divided into a control and treatment group. The treatment group was given the same food as the control group plus ethanol extract of young papaya seeds 20 mg/20 gram body weight as much as 0.5 ml, orally every day for thirty-six days. Data were analyzed using the independent-sample T-test and Mann Whitney test. Result:The levels in the treatment group were significantly (p<0.05) lower than those in the control. Testosterone levels 31,64±1,91 vs 48,67±1,81 nmol/L, spermatozoa count 42,72±3,33 vs 75,89±4,71 cell/field of view, and androgen receptor expression 28,11±3.06% vs 55.07±2.49%. Conclusion:The ethanol extract of young papaya seeds 20 mg/20 g body weight has the antifertility property.
Youth intimate partner violence: barriers and bridges during the ending process
Authors: Korkmaz Sibel
Published: April 2021

A substantial body of existing research offers valuable knowledge about how victims of intimate partner violence (IPV) manage to leave abusive partners. To date, however, such studies have focused on adult women. The present article focuses on abusive youth relationships and how they end, adopting an intersectional approach to place analytic focus on youth, gender and sexuality as societal positions. The data consist of in-depth ‘teller-focused’ interviews with 18 IPV victims aged 17–23 in Sweden. The theory-driven analysis brings to the fore a multilevel Ending Process presenting ‘barriers’ and ‘bridges’ on three levels: the societal, the social and the individual. Societal norms, social arenas and individual factors are all shown to affect youth victimisation as well as the relationship ending process. Gender norms seem to be key in understanding IPV among young women, as they appear to present a challenge to ending abusive relationships. It is important to acknowledge violence in youth intimate relationships and to consider the whole of a young person’s experience of IPV. Researchers, practitioners and policymakers need to be sensitive to how different societal positions interact and affect youth victimisation and young people’s ability to end abusive relationships.
Improving the intensity-contrast image of a noisy digital hologram by convolution of Chebyshev type 2 and elliptic filters
Authors: Ibrahim Dahi Ghareab Abdelsalam
Published: April 2021

In this paper, a new, to the best of our knowledge, technique convolves the windowed Fourier filtering (WFF) of the Fresnel transform with the transfer functions of both Chebyshev type 2 and elliptic filters to enhance the intensity-contrast image of a noisy digital hologram. The recorded digital hologram is reconstructed by the Fresnel approach, the reconstructed intensity-contrast image is transformed by WFF, and the obtained spectrum is convolved in frequency domain with the transfer functions of Chebyshev type 2 and elliptic filters. The result of convolution is transformed by inverse WFF to produce a speckle-free image with a sharp roll-off and no ripples in both pass- and stop-bands. The experimental results with a die in the presence and absence of a rotating ground glass diffuser are shown and demonstrate that the resolution can be effectively enhanced with simple setup and procedure. The proposed technique can improve the capabilities of digital holography in three-dimensional (3D) microscopy.
Isochronous space–time wave packets
Authors: Allende Motz Alyssa M. , Yessenov Murat , Abouraddy Ayman F.
Published: April 2021

The group delay incurred by an optical wave packet depends on its path length. Therefore, when a wave packet is obliquely incident on a planar homogeneous slab, the group delay upon traversing it inevitably increases with the angle of incidence. Here, we confirm the existence of isochronous “space–time” (ST) wave packets: pulsed beams whose spatiotemporal structure enables them to traverse the layer with a fixed group delay over a wide span of incident angles. This unique behavior stems from the dependence of the group velocity of a refracted ST wave packet on its angle of incidence. Isochronous ST wave packets are observed in slabs of optical materials with indices ranging from 1.38 to 2.5 for angles up to 50° away from normal incidence.
Initial validation of the Italian version of the Volition in Exercise Questionnaire (VEQ-I)
Authors: Gallotta Maria Chiara , Bonavolontà Valerio , Guidetti Laura , Baldari Carlo , Innocenti Lorenzo , Cardinali Ludovica , Falcioni Lavinia , di Fronso Selenia , Emerenziani Gian Pietro , Zimatore Giovanna , Bertollo Maurizio
Published: April 2021

The purpose of this study was to validate the Volition in Exercise Questionnaire in Italian language (VEQ-I). The translation and cultural adaptation of the VEQ-I was conducted using the forward-backward translation method. VEQ-I eighteen items correspond to the six-factors structure of the original version. The construct validity was verified by the confirmatory factor analysis (CFA) (CFI = 0.960; TLI = 0.943; RMSEA = 0.039; and SRMR = 0.040). The eighteen items were well distributed in six subscales and the six-factors structure of the questionnaire was supported. Internal Consistency value of the questionnaire was investigated for each subscale of the VEQ-I. Cronbach’s alpha and Omega values of theReasons,Postponing Training,Unrelated Thoughts,Self-Confidence,Approval from OthersandCoping with Failuresubscales were 0.76 (α) and 0.76 (ω), 0.76 (α) and 0.76 (ω), 0.87 (α) and 0.88 (ω), 0.85 (α) and 0.85 (ω), 0.70 (α) and 0.72 (ω) and 0.74 (α) and 0.74 (ω), respectively. They were acceptable in all the six subscales. The concurrent validity was assessed using the correlation among the subscales of VEQ-I measures and those contained in two questionnaires: Psychobiosocial States in Physical Education (PBS-SPE) and Exercise Motivations Inventory (EMI-2).
Three dimensional reconstruction to visualize atrial fibrillation activation patterns on curved atrial geometry
Authors: Abad Ricardo , Collart Orvil , Ganesan Prasanth , Rogers A. J. , Alhusseini Mahmood I. , Rodrigo Miguel , Narayan Sanjiv M. , Rappel Wouter-Jan
Published: April 2021

Background

The rotational activation created by spiral waves may be a mechanism for atrial fibrillation (AF), yet it is unclear how activation patterns obtained from endocardial baskets are influenced by the 3D geometric curvature of the atrium or ‘unfolding’ into 2D maps. We develop algorithms that can visualize spiral waves and their tip locations on curved atrial geometries. We use these algorithms to quantify differences in AF maps and spiral tip locations between 3D basket reconstructions, projection onto 3D anatomical shells and unfolded 2D surfaces.

Methods

We tested our algorithms in N = 20 patients in whom AF was recorded from 64-pole baskets (Abbott, CA). Phase maps were generated by non-proprietary software to identify the tips of spiral waves, indicated by phase singularities. The number and density of spiral tips were compared in patient-specific 3D shells constructed from the basket, as well as 3D maps from clinical electroanatomic mapping systems and 2D maps.

Results

Patients (59.4±12.7 yrs, 60% M) showed 1.7±0.8 phase singularities/patient, in whom ablation terminated AF in 11/20 patients (55%). There was no difference in the location of phase singularities, between 3D curved surfaces and 2D unfolded surfaces, with a median correlation coefficient between phase singularity density maps of 0.985 (0.978–0.990). No significant impact was noted by phase singularities location in more curved regions or relative to the basket location (p>0.1).

Conclusions

AF maps and phase singularities mapped by endocardial baskets are qualitatively and quantitatively similar whether calculated by 3D phase maps on patient-specific curved atrial geometries or in 2D. Phase maps on patient-specific geometries may be easier to interpret relative to critical structures for ablation planning.
Small extracellular vesicles secreted by vaginal fibroblasts exert inhibitory effect in female stress urinary incontinence through regulating the function of fibroblasts
Authors: Sun Xiaoyan , Zhu Huimin , Li Wenjuan , Zhao Li , Li Wenhua , Li Xiaoyong , Xie Zhenwei
Published: April 2021

Stress urinary incontinence (SUI) is a common condition in women and associated with extra-cellular matrix (ECM) reconstruction, which is mainly regulated by fibroblasts. However, the underlying mechanism remains obscure. Small extracellular vesicles (sEVs) play fundamental biological roles in various cellular functions. Some studies suggested that the sEVs were involved in the metabolism of ECM and the function of fibroblasts. The purpose of our study was to investigate the effect of sEVs secreted by vaginal fibroblasts on the pathogenesis of SUI. We showed that the fibroblasts of female anterior vaginal wall secreted sEVs. Moreover, fibroblasts of females with SUI had significantly elevated secretion of sEVs. The collagen contents, proliferation and migration capacity of fibroblasts were decreased when fibroblasts were co-cultured with fibroblasts-derived sEVs (fibroblast-sEVs) from SUI patients. Proteomic analysis revealed that fibroblast-sEVs contained various differentially expressed proteins including TIMP2, TGF-β and ABCC4, which were involved in signaling pathways of fibroblasts regulation. Therefore, we suggested that fibroblast-sEVs contributed to the pathogenesis of SUI through various proteins including TIMP2, TGF-β and ABCC4.
Organismos constitucionales autónomos y calidad de la democracia en Ecuador
Authors: Moscoso Moreno Arturo , Villavicencio Mancero Melina
Published: April 2021

El propósito de este artículo es analizar cómo los Organismos Constitucionales Autónomos (OCA), instituidos en Ecuador a través de la Constitución de 2008 con la creación de la Función de Transparencia y Control Social, en lugar de cumplir su objetivo de contribuir a la accountability horizontal y a la calidad de la democracia en el país, debido a su diseño y cooptación, tuvieron el efecto contrario.
Assessment of the potential of Norway-spruce-seed-orchard associated plants to serve as alternate hosts of Thekopsora areolata
Authors: Kaitera Juha , Kauppila Tuomas , Hantula Jarkko
Published: April 2021

The alternate host range of cherry-spruce rust is poorly studied although such information could be important in protecting spruce seed orchards from infections. Pathogenicity of cherry-spruce rust, (Fr.) Magnus, was investigated on potential alternate host species in a greenhouse and in a laboratory in Finland. Five common species of Ericaceae, L., L., L., L. and (L.) Spreng, were inoculated in the greenhouse using aeciospores from seven Norway spruce [ (L.) H. Karst.] seed orchards suffering from in 2018. In addition, young detached leaves of spp. and 17 other plant species of ground vegetation from eight Norway spruce seed orchards were inoculated with aeciospores from six seed orchards in the laboratory in 2019. Also, young leaves of L. trees growing within the seed orchards or close to them were inoculated as controls. None of the inoculated leaves of the potential alternate hosts formed uredinia either in the greenhouse or in the laboratory. In contrast, leaves of from the seed orchards were infected by the six spore sources from six seed orchards and produced uredinia. As spores were able to infect only , but not the other tested species belonging to ground flora, it was concluded that disperses only via spp. in Finnish seed orchards.Thekopsora areolataVaccinium myrtillusV. uliginosumV. vitis-idaeaEmpetrum nigrumArctostaphylos uva-ursiPicea abiesT. areolataVacciniumPrunus padusP. padusT. areolataP. padusT. areolataPrunus
Como nasce o novo
Authors: Ázara de Oliveira Hélio
Published: April 2021

[...] Como nasce o Novo, lançado em 2018 pela editora Todavia, de autoria de Marcos Nobre. O livro é um trabalho raro de tradução e exegese de um trecho central de um clássico da Filosofia alemã e mundial, Fenomenologia do Espírito, de G. W. F. Hegel. Esta obra pode interessar tanto ao leitor inicial (desde que previamente ciente das dificuldades da empreitada) quanto ao especialista no sentido estrito do termo.

A obra se divide em ao menos três partes principais, 1) uma “Apresentação” de toda a problemática envolvida nesta obra fundamental de Hegel; 2) A tradução da Introdução à Fenomenologia do Espírito, que se faz acompanhar do texto original, sinopticamente disposto; 3) a Análise e comentário do texto, que é completada com a divisão esquemática do texto e com quadros sinópticos da divisão proposta, bem como de uma tábua de termos da tradução adotada. Em cada uma dessas partes, Marcos Nobre explicita seu método e deixa ao leitor opções para seguir ou não os passos do autor, isto é, há um “Manual de instruções” em cada uma das etapas, tornando a obra bastante democrática e aberta.

O livro nos é apresentado já mediante a polêmica, ao que tudo indica infindável, a respeito do “lugar” da Fenomenologia do Espírito na organização sistemática da obra de Hegel. O trabalho minucioso de Marcos Nobre expõe todas as jogadas possíveis desse jogo aberto; realça nuances extremamente sutis entre as interpretações, e consegue fazer o leitor ter a certeza de que só está na largada de uma longa viagem. [...]
O Movimento Escola sem Partido e a captura da docência: O professor como técnico do saber especializado
Authors: Danelon Márcio
Published: April 2021

O Movimento Escola sem Partido e a captura da docência: O professor como técnico do saber especializado

Resumo: Este artigo tem por objetivo refletir sobre formas de captura das práticas pedagógicas do professor presentes no pensamento e no projeto de lei proposto pelo Movimento Escola sem Partido. Em nossa análise, a estratégia de vigilância do trabalho docente, a classificação do trabalho docente como doutrinação e a sobreposição da educação familiar sobre a escolar, emergem como formas de captura da docência, transformando o professor num “técnico do saber especializado”, conforme conceituação de Jean-Paul Sartre.Palavras-chave: Educação. Escola sem partido. Fenomenologia. Sartre.

The school without political party movement and the capture of teaching: the teacher as a specialist knowledge technician

Abstract: This article aims to reflect on ways of capturing the pedagogical practices of the teacher present in the thought and the bill proposed by the School Without Political Party Movement. In our analysis, the strategy of surveillance of teaching work, the classification of teaching work as indoctrination and the overlap of family education over school, emerge as ways of capturing teaching, transforming the teacher into a "specialist knowledge technician", as conceptualization. by Jean-Paul Sartre.Keywords: Education. School Without Political Party. Phenomenology. Sartre. 

Le mouvement école sans parti et la capture de l’enseignement: L’ enseignant comme technicien spécialisé du savoir

Résumé: Cet article vise à réfléchir sur les moyens de capter les pratiques pédagogiques de l’enseignant présent dans la pensée et das le projet de loi proposés par le Mouvement École sans Parti. Dans notre analyse, la stratégie de surveillance du travail d’enseignement, la classification du travail d’enseignement comme endoctrinement et le chevauchement de l’education familier sur l’éducation scolaire, apparaissent comme les raison de capturer de l’enseignement, transformant l’enseignant em um “technicien spécialisé du savoir”, comme conceptualisé par Jean-Paul Sartre.Mots clés: Éducation. École sans parti. Phénoménologie. Sartre.

Data de registro: 17/06/2020Data de aceite: 26/11/2020
Impact of COVID-19 Pandemic on Thailand Economy and Tourist Industry: An Empirical Forecasting Using ARIMA
Authors: Janjua Laeeq Razzak , Muhammad Fida , Sukjai Patthaphon , Rehman Abdul , Yu Zhang
Published: April 2021

Goal: The tourism sector always plays a vital role among other sectors, which contributes heavily to Thailand’s GDP. Due to the recent Pandemic crises, the tourism industry worldwide faces a decline.  The aim of writing this paper is to forecast, tourist inflow for Thailand for the next nine months by using ARIMA forecasting

Design/Methodology/Approach: In order to meet the study objective, we adopted the univariate time series forecasting of tourist arrival. The AR(12) and MA(12) process with d(1) order to specify the appropriate model also applied for forecasting selection of international tourist arrivals, after diagnostic checking of series through correlogram Q-statistics and correlogram of residuals for adjusted ARIMA (12,1,12) in which we found low residual against 70 lags.

Results: The evidence predicts that in the next nine months, Thailand will face significant negative zone arrival of international tourists due to the COVID-19 pandemic crises, which adversely affect Thailand’s economy due to the shortfall of international tourist arrivals. However decline in tourist arrival will eventually decrease air pollution in Thailand, thus it positively impact on environmental quality.

Limitation of the investigation: In terms of limitation of this study, this forecasting is only valid for Thailand based on historical and current data.

Practical implications: We highly recommend government of Thailand for enchasing overall logistics performance and furthermore increase use to renewable energy and green performance in their tourism sector.

Originality / Value: This study provides tourism forecasting estimation for Thailand, which can help government to reshape their tourism policies due to Covid-19 pandemic crises. As this study is the first attempt to provide forecasting related with Covid-19 for tourism sector.
The effect of islands of improvement on the maturity models for industry 4.0: the implementation of an inventory management system in a beverage factory
Authors: Dantas Rafaela , Barbalho Sanderson César Macêdo
Published: April 2021

Goal: Industry 4.0 has the main purpose to turn the company into an agile organization, able to adapt continuously to the dynamicity of the market. Thus, to reach this target, the business should be aware of its current level of readiness and it needs to establish digital strategies to reach higher levels. The goal of this research is to explore how improvements in industry 4.0 can improve companies´ business processes.

Design / Methodology / Approach: The present study is action research that initially identified the most suitable maturity model in Industry 4.0 in the scientific and practitioner literature. Furthermore, the chosen model was applied in a beverage manufacturer to evaluate its current maturity level. Some Industry 4.0 improvements were implemented on the warehouse as part of the company’s digital strategy into which it was integrated the inventory management system with new digital solutions. Finally, interviews were conducted and data was gathered from companies indicators.

Results: The conduct of the action research revealed the current status of the company and how storage management contributed to its digital transformation process. A phenomenon of islands of improvement is discussed at the end.

Limitations of the investigation: Our main limitation is our case study approach. Additionally, more interviews crossing functional areas could bring further elements about the perception of improvements that each functional group had at the end of the implementation process.

Practical implications: The case study suggests that applications of maturity models can generate the phenomena of islands of improvements. Managers must take this situation into account to plan digital transformation in the whole company.

Originality / Value:  The phenomena of the island of improvement is suggested to be a side effect of implementing industry 4.0 based on maturity models.

Keywords: Industry 4.0; maturity model; logistics; inventory; storage management systems; RFID.
Gatunek na usługach doktryny. Ideologia w polsko-enerdowskiej koprodukcji Milcząca gwiazda
Authors: Peplinski Maciej
Published: April 2021

The East German-Polish co-production The Silent Star (1960, Kurt Maetzig) belongs to the group of early postwar Eastern European science fiction films which still remain barely examined by film and genre historians. The article summarizes the existing research on the film and investigates not only the specific formal character of Maetzig’s unprecedented project, but also the numerous ideological and political motivations which stood behind it.
Renata Czaplikowska/Artur Dariusz Kubacki Kleines Fachlexikon der Daf-Didaktik. Theorie und Unterrichtspraxis
Authors: Sowa-Bacia Katarzyna
Published: April 2021

Wydawnictwo Biuro Tłumczeń Kubart, Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie, Chrzanów – Kraków 2019, 248 s.
NEGATIVE FEEDBACK SEEKING AND EXCESSIVE REASSURANCE SEEKING BEHAVIOR AND DEPRESSION: A META-ANALYTIC REVIEW
Authors: Wakeling Scott , Stukas Arthur A. , Wright Bradley J. , Evans Lynette
Published: April 2021

Introduction: Negative feedback seeking and excessive reassurance seeking behaviors in interpersonal relationships have been shown to frequently occur in conjunction with levels of depression.

Method: We used meta-analysis to examine 102 studies (134 effects), relating depression with negative feedback seeking (k = 31) and/or excessive reassurance seeking (k = 103).

Results: Depression had positive, moderate effect sizes with both negative feedback seeking (r = .26, 95% CI [.21, .32], p < .001, k = 31) and excessive reassurance seeking (r = .33, 95% CI [.31, .36] p < .001, k = 103). Subgroup analysis revealed the effect size for negative feedback seeking was smaller in romantic relationships compared to other relationship types. Effect sizes for excessive reassurance seeking did not differ for romantic and other relationships but were smaller in romantic relationships of a longer duration. Participant gender and symptom severity did not moderate effect sizes. Studies with child and adolescent samples had larger effects for negative feedback seeking and smaller effects for excessive reassurance seeking, relative to adult samples.

Discussion: Longer closer relationships may protect against maladaptive interpersonal behaviors in individuals with depression.
Facial Emotion Perception in Families Affected With Borderline Personality Disorder
Authors: Gulamani Tahira , Rodrigo Achala H. , Uliaszek Amanda A. , Ruocco Anthony C.
Published: April 2021

Emotion perception biases may precipitate problematic interpersonal interactions in families affected with borderline personality disorder (BPD) and lead to conflictual relationships. In the present study, the authors investigated the familial aggregation of facial emotion recognition biases for neutral, happy, sad, fearful, and angry expressions in probands with BPD (n = 89), first-degree biological relatives (n = 67), and healthy controls (n = 87). Relatives showed comparable accuracy and response times to controls in recognizing negative emotions in aggregate and most discrete emotions. For sad expressions, both probands and relatives displayed slower response latencies, and they were more likely than controls to perceive sad expressions as fearful. Nonpsychiatrically affected relatives were slower than controls in responding to negative emotional expressions in aggregate, and fearful and sad facial expressions more specifically. These findings uncover potential biases in perceiving sad and fearful facial expressions that may be transmitted in families affected with BPD.
A Q Methodology Study of Supervisee Roles Within a Counseling Practicum Course
Authors: Baltrinic Eric R. , Cook Ryan M. , Fye Heather J.
Published: April 2021

Counseling students often experience clinical supervision for the first time during their participation in practicum courses. Counseling practicum supervisees new to supervision rely on their supervisors to provide direction and structure in supervision experiences to help them grow professionally and personally. Yet little is known about how students view their roles as new supervisees. Supervisors can benefit from structuring and delivering their courses informed by new supervisees’ perspectives on their roles. Accordingly, the authors conducted a Q methodology study with a purposeful sample of seven counseling practicum students, a doctoral co-instructor, and a counseling practicum instructor engaged in a first-semester counseling practicum course. Principal components analysis with varimax rotation of Q-sort data revealed three factors depicting supervisee roles (i.e., Dutiful, Discerning, and Expressive Learners). Implications for applying findings to improve supervision instruction and student learning are discussed, including limitations and future research suggestions.