bluuebunny/crossref_metadata_2025 huggingface dataset:
Thinking in Between Disciplines
Authors: Ochs Elinor
Published: May 2022

Academic disciplines are shape-shifting zones of inquiry yet notably bounded by regimes of training, truth, genre, and aesthetics. This article journeys into liminal zones in between disciplines as an existential space to ponder matters that beg for release from disciplinary syllabi. Can one thrive or even survive in the academy while dwelling in intervals between scholarly footprints? I lay bare a life of thinking in between anthropology, linguistics, and psychology for the reader to pursue and complicate this question. Try as I might to steer clear of folly, I have thrown caution to the winds to suggest affordances that nourish transgressive thinking in ways that expand and reassemble thinkable objects of inquiry.
Bureaucracy and Development
Authors: Besley Timothy , Burgess Robin , Khan Adnan , Xu Guo
Published: May 2022

In recent years, there has been increasing interest in whether and how bureaucratic effectiveness contributes to development. Just what makes for an effective bureaucracy and what are the building blocks of state capacity remain subject to debate. This article reviews the arguments connecting contemporary research using administrative data and field experiments to wider discussions of the origins of state capacity. Most current research has focused on understanding specific features of the environment in which bureaucrats operate. We connect this to discussions of bureaucratic systems, specifically the relationship to politics, citizens, firms, and nongovernmental organizations.
Material Flows and Efficiency
Authors: Cullen Jonathan M. , Cooper Daniel R.
Published: May 2022

Attempts to track material flows and the calculation of efficiency for material systems go hand in hand. Questions of where materials come from, where materials go to, and how much material is lost along the way are embedded in human societies. This article reviews material flows, their analysis, and progress toward material efficiency. We focus first on material flow analysis (MFA) and the three key tenets of any MFA: presentation of materials, visualization of the flow structure, and insight derived from analysis. Reviewing recent literature, we explore how each of these concepts is described, organized, and presented in MFA studies. We go on to show the role of MFA in material efficiency calculations and what-if scenario analysis for informed decision-making. We investigate the origins and motivations behind the material efficiency paradigm and the key efficiency strategies and practices developed in recent years and conclude by suggesting priorities for a future research agenda.
Heat shock proteins in pulmonary fibrosis: pawns of cell homeostasis
Authors: Roque Willy
Published: May 2022

Idiopathic pulmonary fibrosis (IPF) is a fatal disease that primarily affects the elderly. Up to date, the specific pathogenesis of IPF remains unknown. However, it is theorized to be caused by chronic repetitive injuries to the alveolar epithelium, eventually exhausting the stem cell capacity and activating pathological pathways. Heat shock proteins (HSPs), a category of stress response proteins, are also suggested to contribute to IPF pathogenesis. Furthermore, HSPs are key components in the regulation of cell homeostasis and act as chaperones for a multitude of new proteins. This review thoroughly evaluates the roles that specific HSPs, HSP90, HSP70, and HSP47, have in the fibrotic process. A close look into the roles of these HSPs in IPF pathogenesis will give valuable insight into the future of IPF treatment and prevention.
Sex differences in IL-10’s anti-inflammatory function: greater STAT3 activation and stronger inhibition of TNF-α production in male blood leukocytes ex vivo
Authors: Islam Hashim , Jackson Garett S. , Yoon Jeff S. J. , Cabral-Santos Carolina , Lira Fábio S. , Mui Alice L. , Little Jonathan P.
Published: May 2022

Interleukin-10 (IL-10) inhibits proinflammatory cytokine production in blood leukocytes—an effect mediated by signal transducer and activator of transcription 3 (STAT3) activation. To examine potential sex-based differences in IL-10’s anti-inflammatory function, we treated whole blood from healthy males and females ( n = 16 participants of each sex; age: 28 ± 6 yr; body mass index: 23.5 ± 2.3 kg/m2) with increasing concentrations of IL-10 (1–100 ng/mL) and quantified changes in phosphorylated STAT3 (pSTAT3) in CD14+ monocytes and CD4+ lymphocytes via flow cytometry. In parallel, liposaccharide (LPS)-stimulated whole blood cultures were used to assess sex-based differences in IL-10’s ability to inhibit tumor necrosis factor (TNF)-α production. IL-10 concentration dependently increased pSTAT3 median fluorescent intensity (MFI) in CD14+ and CD4+ cells (main effects of concentration, P < 0.01) with males exhibiting larger changes in pSTAT3 MFI in both cell types (main effects of sex, P < 0.01). Accordingly, IL-10-mediated inhibition of TNF-α production was more pronounced in males (main effect of sex, P < 0.01) with changes in other monocyte-derived cytokines (IL-1β, IL-1RA, and IL-15) also supporting a sexual dimorphism in IL-10 action ( P < 0.05). These sex-based differences were not explained by differences in circulating plasma IL-10 concentrations, basal IL-10 receptor expression in unstimulated CD14+ and CD4+ cells, nor the basal expression of IL-10 signaling proteins (STAT3, SHIP1, and p38 MAPK) in unstimulated peripheral blood mononuclear cells. We conclude that IL-10’s anti-inflammatory function differs between male and female blood leukocytes ex vivo. This sexual dimorphism should be considered in future work investigating IL-10’s anti-inflammatory action in humans as it may represent a mechanism contributing to sex differences in overall immune function.
Subcellular trafficking and endocytic recycling of KATP channels
Authors: Yang Hua-Qian , Echeverry Fabio A. , ElSheikh Assmaa , Gando Ivan , Anez Arredondo Sophia , Samper Natalie , Cardozo Timothy , Delmar Mario , Shyng Show-Ling , Coetzee William A.
Published: May 2022

Sarcolemmal/plasmalemmal ATP-sensitive K+ (KATP) channels have key roles in many cell types and tissues. Hundreds of studies have described how the KATP channel activity and ATP sensitivity can be regulated by changes in the cellular metabolic state, by receptor signaling pathways and by pharmacological interventions. These alterations in channel activity directly translate to alterations in cell or tissue function, that can range from modulating secretory responses, such as insulin release from pancreatic β-cells or neurotransmitters from neurons, to modulating contractile behavior of smooth muscle or cardiac cells to elicit alterations in blood flow or cardiac contractility. It is increasingly becoming apparent, however, that KATP channels are regulated beyond changes in their activity. Recent studies have highlighted that KATP channel surface expression is a tightly regulated process with similar implications in health and disease. The surface expression of KATP channels is finely balanced by several trafficking steps including synthesis, assembly, anterograde trafficking, membrane anchoring, endocytosis, endocytic recycling, and degradation. This review aims to summarize the physiological and pathophysiological implications of KATP channel trafficking and mechanisms that regulate KATP channel trafficking. A better understanding of this topic has potential to identify new approaches to develop therapeutically useful drugs to treat KATP channel-related diseases.
Kv4.2 phosphorylation by PKA drives Kv4.2-KChIP2 dissociation, leading to Kv4.2 out of lipid rafts and internalization
Authors: Li Ying , Duan Haixia , Yi Jing , Wang Gang , Cheng Wanwen , Feng Li , Liu Jie
Published: May 2022

Sympathetic regulation of the Kv4.2 transient outward potassium current ( Ito) is critical for the acute electrical and contractile response of the myocardium under physiological and pathological conditions. Previous studies have suggested that KChIP2, the key auxiliary subunit of Kv4 channels, is required for the sympathetic regulation of Kv4.2 current densities. Of interest, Kv4.2 and KChIP2, and key components mediating acute sympathetic signaling transduction are present in lipid rafts, which are profoundly involved in regulation of Ito densities in rat ventricular myocytes. However, little is known about the mechanisms of Kv4.2-raft association and its connection with acute sympathetic regulation. With the aid of high-resolution fluorescent microscope, we demonstrated that KChIP2 assisted Kv4.2 localization in lipid rafts in HEK293 cells. Moreover, PKA-mediated Kv4.2 phosphorylation, the downstream signaling event of acute sympathetic stimulation, induced dissociation between Kv4.2 and KChIP2, resulting in Kv4.2 shifting out of lipid rafts in KChIP2-expressed HEK293. The mutation that mimics Kv4.2 phosphorylation by PKA (K4.2-S552D) similarly disrupted Kv4.2 interaction with KChIP2 and also decreased the surface stability of Kv4.2. The attenuated Kv4.2-KChIP2 interaction was also observed in native neonatal rat ventricular myocytes (NRVMs) upon acute adrenergic stimulation with phenylephrine (PE). Furthermore, PE stimulation decreased Kv4.2 location at lipid rafts and induced internalization of Kv4.2 as well as the effect of lipid rafts disruption. In conclusion, KChIP2 contributes to targeting Kv4.2 to lipid rafts. Acute adrenergic stimulation induces Kv4.2-KChIP2 dissociation, leading to Kv4.2 out of lipid rafts and internalization, reinforcing the critical role of Kv4.2-lipid raft association in the essential physiological response of Ito to acute sympathetic regulation.
Convergent effects of neuropeptides on the feeding central pattern generator of Aplysia californica
Authors: Due Michael R. , Wang Yanqing , Barry Michael A. , Jing Jian , Reaver Carrie N. , Weiss Klaudiusz R. , Cropper Elizabeth C.
Published: May 2022

The activity of multifunctional central pattern generators (CPGs) is often configured by neuromodulators that exert divergent effects that are necessary to specify motor output. We demonstrate that ingestive and egestive inputs to the feeding CPG in Aplysia act convergently (as well as divergently). We ask why this convergence may be important and suggest that it may be a mechanism for a type of arousal that occurs during task switching.
Visual cortex responds to sound onset and offset during passive listening
Authors: Brang David , Plass John , Sherman Aleksandra , Stacey William C. , Wasade Vibhangini S. , Grabowecky Marcia , Ahn EunSeon , Towle Vernon L. , Tao James X. , Wu Shasha , Issa Naoum P. , Suzuki Satoru
Published: May 2022

Using intracranial electroencephalography (iEEG) in humans during a passive listening task, we demonstrate that sounds modulate activity in visual cortex at both the onset and offset of sounds, which likely supports visual timing and duration processing. However, more complex auditory rate information did not affect visual activity. These findings are based on one of the largest multisensory iEEG studies to date and reveal the type of information transmitted between auditory and visual regions.
Risk Identification and Application of Farmland Management Right Mortgage Loan Based on Neural Network
Authors: Lan Qi , Pang Jinbo
Published: May 2022

There are a series of problems in China, such as low farmers’ income, difficulty in financing for farmers, and relatively lag in rural financial reform. The mortgage financing of farmland management rights is one of the important ways to solve these thorny problems and promote economic development. From the perspective of farmers, combined with empirical analysis, this paper fully considers farmers’ ideas, carries out risk identification and risk assessment for the mortgage loan of farmland management rights, and continuously improves the relevant risk prevention mechanism to reduce the operation risk of farmers’ farmland mortgage. This paper expounds the establishment principles of the risk evaluation index system in detail, lays a theoretical foundation for the selection of indicators, determines the risk evaluation system of land management right mortgage financing from the perspective of farmers, and builds a fuzzy-level comprehensive evaluation model. Based on the practical research data, the fuzzy hierarchy (F-AHP) comprehensive evaluation method is used to conduct an empirical comprehensive evaluation on the risk of the mortgage loan of the farmland management right and analyze the evaluation results. Among the surveyed farmers in the survey area, 242 have not actually participated in the mortgage loan of farmland management rights, accounting for 94.16% of the sample farmers. However, there are only 15 farmers who actually use the farmland management right for mortgage financing, accounting for 5.84% of the sample.
Deformation Characteristics and Control Technology of Roadway in Water-Rich Soft Rock
Authors: Lin Weiguo , Cheng Jianliang , Li Dalei , Dang Haibo
Published: May 2022

Jurassic soft rocks are the main coal-bearing strata in western mining areas, which are rich in water and high in expansive minerals. The roof and floor of the coal seam are easily muddied and disintegrated when affected by water, and heave floor of roadway in soft rock has become one of the problems that restricts the safety and efficient production of coal mines in western mining areas. It is not ideal for the effect of the traditional roadway control theory on geological soft rock roadway support, and the deformation is difficult to control. Take the tailgate of 11506 working face of a coal mine in the western mining area as the research background. This surrounding rock conditions and the deformation characteristics of the roadway in tailgate of 11506 working face were analyzed systematically, and the optimization design of the support scheme of the water-rich soft rock roadway was carried out by using theoretical analysis and numerical simulation. The application of the support in the tailgate of 11506 working face was carried out. The results show that slip of the two sidewalls, support failure, stress concentration, and floor heave were failure characteristics in water-rich soft rock roadway. The optimization of the roadway section, thin guniting of the roadway surface, optimization of support components, and gradient support could effectively achieve the control of soft rock roadway deformation. The maximum floor heave during the roadway deformation monitoring period was 230 mm, which decreased about 75% compared with original support. The influence range of the advance abutment stress is 0~60 m, of which 0~30 m is the serious influence area. The research results have good engineering practice significance for the control of bottom bulge of the soft rock roadway in this coal mine and western mining area.
Research on Calculation of Rail Self-Impedance of Track Circuit Based on Partial Element Equivalent Circuit
Authors: Zhao Bin , Yu Guanghao , Wang Dong , Ou Jingning , Chen Lei
Published: May 2022

The self-impedance of the steel rail, as the signal transmission medium in the electrified railway track circuit, has a direct impact on the track circuit’s transmission performance. The finite element method is the most common method for calculating rail impedance, although it has a number of drawbacks, including a complicated model, a long computation time, and poor accuracy. The partial element equivalent circuit (PEEC) approach is used in this paper to provide a method for determining rail self-impedance. Firstly, the rail equivalent method is determined by analyzing the physical model of the rail. Considering the skin effect, the PEEC model of the rail is established. The internal impedance of the rail can be obtained by solving the equivalent circuit. The external impedance considering the influence of the earth is calculated by the Carson impedance calculation formula, which is processed by the segmented linear approximation method. The rail’s self-impedance is determined using the two procedures together. Finally, the actual measurement data verified the PEEC method to calculate the rail impedance. Compared with the finite element method (FEM), the calculation accuracy of the PEEC method is higher. The current frequency, the height of the rail from the ground, and the earth’s conductivity impact on the rail’s self-impedance are analyzed. The results show that the PEEC technique can be used to calculate the rail’s self-impedance and that the impact of current frequency, rail height above the ground, and ground conductivity on the rail’s self-impedance may be accurately represented. The self-impedance computation of the track circuit provides a theoretical basis.
Role of Lactium™ in Psychodermatology: The CERTAIN Trial# on Patients with Acne Vulgaris
Authors: Kerure Amit Shivaji , Udare Satish , Vispute Chetan
Published: May 2022

Stress plays an important role in the causation and aggravation of psychodermatological conditions such as acne vulgaris. Alpha casein hydrolysate (αs1‐casein hydrolysate; Lactium) has been shown to decrease serum cortisol levels, reduce stress‐related symptoms, and promote relaxation. “This study aimed to compare the efficacy and safety of Lactium™ plus standard care to those of standard of care alone in reducing stress levels and acne severity in patients with acne vulgaris.” The C.E.R.T.A.I.N trial (Name registered with Clinical Trials Registry‐India‐No. CTRI/2019/01/017172) is a randomized, controlled, multicenter, open‐label, two‐arm, investigator‐initiated clinical trial. A total of 100 patients with moderate‐to‐severe acne vulgaris were enrolled and randomly assigned to one of the two groups: Lactium™ plus standard care or standard care alone. Stress levels were assessed using serum cortisol levels, Investigator’s Global Assessment (IGA) acne severity scale scores, Perceived Stress Scale (PSS) scores, and the Hamilton Anxiety Rating Scale (HAM‐A) scores. The Dermatology Life Quality Index (DLQI) was also used to assess the impact of the skin disease on patients’ quality of life. At 12 weeks, stress levels were significantly lower in group A (Nixiyax plus standard of care) than that in group B(only standard care), as measured by the change in serum cortisol levels (4.75 ± 4.46 vs. −0.24 ± 5.22). Furthermore, the mean change in PSS scores (3.09 ± 2.04 vs. 0.90 ± 2.76) and HAM‐A scores (5.11 ± 1.94 vs. 1.25 ± 3.13) was significant. Patients in both arms had a significant decrease in total, inflammatory, and noninflammatory acne lesions, as well as a significant improvement in DLQI and IGA scores. In patients with moderate‐to‐severe acne vulgaris, Lactium™ was found to be both safe and well‐tolerated. Lactium™ plus standard care is more effective than standard care alone in reducing acne severity through stress reduction.
miR-340-5p Alleviates Oxidative Stress Injury by Targeting MyD88 in Sepsis-Induced Cardiomyopathy
Authors: Zhang Cong , Zeng Lijin , Cai Guoyi , Zhu Yuanting , Xiong Yan , Zhan Hong , Yang Zhen
Published: May 2022

Background. Sepsis-induced cardiomyopathy (SIC) is a sort of severe disease in the intensive care unit. This research focuses on exploring the influence of miR-340-5p on SIC and its specific mechanism. Methods. Mice were administered with lipopolysaccharide (LPS) to construct a SIC animal model. Mice were intramyocardially injected with Adenoassociated Virus- (AAV-) 9 containing the miR-340-5p precursor to make the miR-340-5p overexpression in the myocardium. The expression level of myocardial miR-340-5p was evaluated by qRT-PCR. The cardiac function was measured by echocardiography, the myocardial morphology was observed by hematoxylin-eosin (HE) staining, and the oxidative stress level was detected by 4-hydroxynonenal (4-HNE) immunohistochemical staining and malondialdehyde (MDA) assay in mice. The cells were pretreated with miR-340-5p mimic, mimic-NC, miR-340-5p inhibitor, inhibitor-NC, MyD88 siRNA, or si-NC and then administered with LPS or PBS. The cell viability was measured with the CCK-8 assay. The level of intracellular oxidative stress was evaluated using reactive oxygen species (ROS), MDA, and glutathione (GSH) detection. The MyD88 level was assessed via Western blotting analysis. The interaction of miR-340-5p with the MyD88 mRNA was confirmed via dual-luciferase reporter assay and RNA pull-down assay. Results. The miR-340-5p overexpression partially alleviated the increase of the MyD88 level, impairment of cardiac function, and oxidative stress injury in the SIC animal model. In the SIC cell model, miR-340-5p mimic pretreatment partially relieved oxidative stress injury, while the miR-340-5p inhibitor had the opposite effect. Besides, the miR-340-5p mimic and inhibitor could reduce and further increase the MyD88 level in the SIC cell model, respectively. Dual-luciferase reporter and RNA pull-down experiments confirmed the interaction between the MyD88 mRNA and miR-340-5p. Finally, it was found that MyD88 siRNA pretreatment also partially alleviates the oxidative stress injury in the SIC cell model. Conclusion. In sum, our study demonstrated that miR-340-5p can improve myocardial oxidative stress injury by targeting MyD88 in SIC.
Prevention and Detection Research of Intelligent Sports Rehabilitation under the Background of Artificial Intelligence
Authors: Huang Qiong , Wang Fubin
Published: May 2022

Artificial intelligence can bring convenience to human life. In the field of sports rehabilitation, the application of artificial intelligence is becoming more and more in-depth. This paper is aimed at studying the prevention and detection of sports rehabilitation in the context of artificial intelligence and proposing a compliance control method for lower limb rehabilitation robots based on artificial neural networks. In this paper, a double closed-loop control system is designed: the outer loop is an adaptive impedance control model based on sEMG feedback, and the purpose is to adjust the predicted desired joint trajectories. In the inner loop, a sliding mode iterative learning controller is designed to suppress periodic disturbance and abnormal jitter and achieve stable tracking of the target trajectory. Finally, the control method is simulated and verified by matlab/simulink, and a statistical experiment is done on the patient’s recovery. The experimental results show that the use of artificial intelligence technology can effectively increase the sensitivity of the control system and improve the recovery rate of patients. Compared with the traditional sports rehabilitation control system, the sensitivity is increased by 22.7%, and the patient recovery rate is increased by 10.4%, which is of great significance in the field of sports rehabilitation.
A Delayed Presentation of Perforated Diffuse Large B Cell Lymphoma of the Small Bowel Resulting in a Large Interloop Faecaloma
Authors: Zishan Muhammed A. , Raufian Kasra
Published: May 2022

Primary small bowel lymphomas are a rare entity but with significant morbidity and a low five-year overall survival even after surgery. Its diagnosis is often delayed due to the lack of clear specific signs, unfamiliarity amongst clinicians, and the lack of screening tools. This often results in patients presenting with tumour-associated complications such as perforation, obstruction, or gastrointestinal bleeding which warrant urgent surgical intervention. We present the case of a patient presenting with a perforated small bowel lymphoma resulting in a large interloop extraluminal faecaloma causing subacute small bowel obstruction. He proceeded to have an emergency open right hemicolectomy and extended small bowel resection to facilitate gross resection of tumour which in conjunction with adjuvant systemic chemotherapy is considered current best practice to manage such neoplasms. Early referral to specialist centres and raising awareness of this rare entity will allow earlier recognition and therefore a more planned approach to the management of such pathology with fewer post-operative complications.
An English Teaching Ability Assessment Method Based on Fuzzy Mean-Shift Clustering
Authors: Wu Tingting , Wen Minlin
Published: May 2022

This paper presents an in-depth study and analysis of the assessment of English teaching ability using the algorithm of fuzzy mean-shift clustering. The paper proposes an automatic scoring model for Chinese-English sentence-level interpretation based on semantic scoring. The automatic scoring model calculates candidates’ Chinese-English sentence interpretation scores by fusing the feature parameters at both the phonological and content levels. Adaptive weights are introduced to fuse the current pixel and the neighborhood mean with adaptive weighting, and the weighted entropy constraint term is embedded in the clustering objective function to solve the selection problem of the weighting parameters. Finally, the graphical fuzzy division information of the neighboring pixels is used to construct the local spatial information constraint term of the current pixel, and the graphical fuzzy division term of the current pixel is adjusted to correct the clustering center obtained from the iteration. Fluency is selected as the feature scoring parameter at the speech level, and the automatic scoring model directly scores the fluency features of the candidates’ recordings; two feature scoring parameters, keywords, and sentence semantics are selected at the content level, and the content features are scored after converting the candidates’ recordings to text by manual conversion. The zero-energy product method is used to extract speech features to calculate fluency feature scores; the semantic scoring model introduced in this paper is used to calculate keyword and sentence semantic feature scores; finally, the random forest algorithm is used to fuse the above three feature scoring parameters to obtain the total quality score of Chinese-English interpretation. Considering the correlation of neighborhood pixel affiliation, the KL scatter and affiliation space information is used to supervise the current pixel affiliation, to further improve the segmentation accuracy of the algorithm; finally, segmentation tests are conducted on synthetic images, medical images, and remote sensing images. The results show that the proposed algorithm has a stronger noise suppression ability and can obtain more satisfactory segmentation results than other robust fuzzy clustering algorithms.
Improved Hybrid Response Surface Method Based on Double Weighted Regression and Vector Projection
Authors: Xia Yu , Wang Yeming
Published: May 2022

In order to increase the accuracy and stability of the classical response surface method and relevant method, a new improved response surface method based on the idea of double weighting factors and vector projection method is proposed. The response surface is fitted by the weighted regression technique, which allows the sampling points to be weighted by their distance from the true failure surface and that from the estimated design point. It uses the vector of the gradient projection method to get new sampling points in the process of iteration, in order to make the sampling points closer to the design point, and the value of deviation coefficient is constantly adjusted. To some extent, these strategies increase the accuracy and stability of the response surface method, while the calculation time is decreased. At last, the rationality and efficiency of the proposed method are demonstrated through five examples. Besides, as revealed from this investigation, compared with other conventional algorithms, this method has a few obvious advantages; this algorithm not only has high precision and efficiency, but also has solid stability.
Control Strategy of Frequent Overflow at Intersection Based on Remote Sensing of Unmanned Aerial Vehicle and Vehicle Trajectory Data
Authors: Zhang Lili , Wang Xinzhe , Su Lichen , Wang Fang , Wei Wei , Xu Jiamei , Li Jing , Yu Pei , Zhao Qi
Published: May 2022

This paper proposed an effective method, the overflow control strategy, for identifying and controlling the frequent overflow of signalized intersections based on the unmanned aerial vehicle (UAV) remote sensing and vehicle trajectory data that provide multi-dimensional vehicle dynamic data. This strategy can effectively control the overflow intersection and restore normal operation as soon as possible. The strategy was implemented as follows. First, UAV remote sensing was used to quickly find the overflow precursor at the intersection. Second, by using moving trajectory data, the second-flow model of the road section was constructed, and overflow identification indexes were established. Third, considering the traffic demand of controlled intersection and non-overflow phase from the global perspective, the queue length model of the non-overflow phase based on moving trajectory data was established and overflow identification indexes were taken as the objective function to design overflow control strategy set. Finally, according to the sampling rate requirement of moving trajectory data and the field traffic survey, the Changping District in Beijing, which meets the requirements, is selected as the case study for simulation and verification. Usually, when overflow occurs, total delay time and the average number of stop cycles at intersections are relatively high. However, by taking the proposed method, overflow at intersections was identified quickly, and a control strategy was implemented immediately, which alleviated the overflow and eventually eliminated it. The results show that the method proposed in this paper can accurately detect the occurrence of overflow, restrain and eliminate the overflow eventually.
Screening of Serum Exosomal miRNAs as Diagnostic Biomarkers for Gastric Cancer Using Small RNA Sequencing
Authors: Wang Jun-fu , Jiang Yue-mei , Zhan Wen-hui , Ye Shan-ping , Li Tai-yuan , Zhang Jiang-nan
Published: May 2022

Background/Aim. Exosomal miRNAs are promising tumor biomarkers. This research explored the diagnostic value of serum exosomal miRNAs by analyzing the exosomal miRNAs derived from the serum of gastric cancer patients. Methods. Deep sequencing of exosomal miRNAs was performed using an Illumina HiSeq2500 sequencer on serum samples from three healthy subjects in the normal control group (group N) and six gastric cancer patients in the gastric cancer treatment group (group T). Bioinformatics analysis was performed on exosomal miRNA profiles to screen differentially expressed miRNA. In addition, target gene prediction, GO, and KEGG pathway enrichment analyses were performed. Finally, the serum exocrine bodies of 24 patients with gastric cancer and 24 normal controls were verified by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) to confirm the findings. The receiver operating characteristic (ROC) curve of the subjects was plotted, and the area under the curve (AUC) was calculated with a 95% confidence interval (CI). Results. The exosomes were successfully extracted from the serum of gastric cancer patients, which showed a form of goblet vesicles or irregular circles, with an average particle size of approximately 102.3 nm. The exosomal marker proteins, CD9, CD63, TSG101, and calnexin, were positively expressed. Small RNA sequencing detected 15 different types of RNA components in the serum exosomes, and the most abundant one was miRNA. In the screened cohort, the downregulation of seven existing miRNAs and the upregulation of one existing miRNA were observed. Four of them were selected for confirmation, revealing that the expression of miR-10401-3p, miR-1255b-5p, and miR-6736-5p declined significantly in group T (

P
<
0.05

). In addition, the ROC curve showed that the AUC values for these three miRNAs were 0.8333, 0.8316, and 0.8142, respectively; all of them are statistically significant (

P
<
0.05

). Conclusions. The above three miRNAs found in the serum exosomes from gastric cancer patients might serve as diagnostic biomarkers for gastric cancer.
LUNAR: A Practical Anonymous Network Simulation Platform
Authors: Zheng Xianchun , Yan Haonan , Wang Rui , Zhang Ziwei , Li Hui
Published: May 2022

With the expansion of cyberspace and the increasing importance of users for privacy protection, anonymous network research has been further developed, especially for the numerous internet of things (IoT) devices. However, when we repeat the existing experiment in an anonymous network, there are many problems such as too old version, low realism, poor operability, and so on. In this paper, we analyzed the design requirements and topology of the new experimental platform. Two topologies with different levels of complexity are designed. We also set up a practical anonymous network simulation platform called LUNAR with virtualization, software-defined networking (SDN), and other technologies to solve those problems. The platform we proposed supports multiprotocol and reproducible complex networks with centralized management. Finally, we implement our simulation platform and reproduce two typical attacks, that is, time-linked Tor node reset attack and website fingerprint attacks on The Onion Router (Tor) network, to evaluate the platform. Experiments results indicate the practicality and superiority of our simulation platform in terms of anonymous network simulation.
Genealogical Clustering and Coordination Analysis of Knowledge-Driven Labor Competitiveness in the Context of Sharing Economy
Authors: Yun Lou
Published: May 2022

In recent years, with the continuous development of information technology and the advent of the Internet + era, the sharing economy has not only changed people’s life and consumption patterns but also reconstructed the value cocreation process between enterprises and customers. Unlike the traditional economic model in which the enterprise is the dominant player, in the sharing economy, the enterprise withdraws from the dominant position in the value creation process and becomes a platform to support and serve the value creation of users (customers in the traditional economic model), and users become the dominant player in value creation. Users are not only the core subject of value cocreation in the sharing economy model but also the key factor determining the profitability of enterprises and the image of the platform. Bilateral users create rich value for individual users, platform enterprises, and society through value creation behaviors such as trading of the right to use idle resources and online and offline communication and interaction. Therefore, it is necessary to study the value cocreation behaviors of bilateral users of shared service platforms. This paper studies the value cocreation of bilateral users of shared service platforms, hoping to help platform enterprises further understand user behavior and needs, better fulfill the role of support and service in the process of value cocreation, provide a good value cocreation environment for bilateral users, enhance the reputation and influence of platform enterprises through user value cocreation behaviors, expand market share, and form competitive advantages. This paper stands in the perspective of intellectual enterprises and studies the problem of knowledge sharing. From the perspective of individuals, it mainly analyzes the willingness and ability of individual knowledge sharing, focusing on the “prisoner’s dilemma” in game theory to study the willingness of individuals to share. From the perspective of knowledge, we mainly analyze the interference brought by the implicit and exclusive nature of knowledge to knowledge sharing, focusing on the implicit nature of knowledge. In addition, this paper only studies the influence of value cocreation of consumer users on value cocreation of resource users and does not deeply explore whether the value cocreation of resource users influences the value cocreation of consumer users.
Main Factors of Mesozoic Tectonic Deformation in the Erlian Basin, Inner Mongolia, China: Insights from Physical Modelling
Authors: Zhao Yue , Xu Qiang , Li Yongchen , Bai Xiujia , Ding Rong , Wang Jianxin , Hou Tao
Published: May 2022

Erlian Basin is a Mesozoic oil and gas-bearing basin in northeast of China. The extension rate, extension direction, and stratum thickness of this rift basin have a clear control on its shape and extension. In this study, we design three sandbox models of the Erlian Basin to represent the effects of changing these three factors. The extension rate controls the timing of secondary fault formation inside the rift basin; a high extension rate promotes faster deformation inside the rift. The extension direction controls the strike of the fault inside the rift; a greater angle between the extension direction and the normal direction of the strike of the rift favors rapid evolution of internal secondary faults. The stratum thickness represents the control of sedimentation on the rift basin; the thinner the brittle layer, the wider the rift. The simulation results also show that the extension direction is the major factor controlling tectonic deformation in the basin. Stratum thickness and extension rate are secondary controlling factors. Additionally, according to geometric and kinematic similarities between typical Mesozoic rift basins in eastern and adjacent areas of China, we suggest that southeastward extension is a possible kinematic mechanism for basin formation.
Down-Regulation of Insulin Like Growth Factor 1 Involved in Alzheimer’s Disease via MAPK, Ras, and FoxO Signaling Pathways
Authors: Kang Kexin , Bai Jun , Zhong Shanshan , Zhang Rongwei , Zhang Xiaoqian , Xu Ying , Zhao Mei , Zhao Chuansheng , Zhou Zhike
Published: May 2022

The inability to halt or even delay the course of Alzheimer’s disease (AD) forces the development of new molecular signatures and therapeutic strategies. Insulin like growth factor 1 (IGF1) is a promising target for AD treatment, yet exact mechanisms of AD ascribed to IGF1 remain elusive. Herein, gene expression profiles of 195 samples were analyzed and 19,245 background genes were generated, among which 4,424 differentially expressed genes (DEGs) were overlapped between AD/control and IGF1-low/high groups. Based on such DEGs, seven co-expression modules were established by weight gene correlation network analysis (WGCNA). The turquoise module had the strongest correlation with AD and IGF1-low expression, the DEGs of which were enriched in GABAergic synapse, long-term potentiation, mitogen-activated protein kinase (MAPK), Ras, and forkhead box O (FoxO) signaling pathways. Furthermore, cross-talking pathways of IGF1, including MAPK, Ras, and FoxO signaling pathways were identified in the protein-protein interaction network. According to the area under the curve (AUC) analysis, down-regulation of IGF1 exhibited good diagnostic performance in AD prediction. Collectively, our findings highlight the involvement of low IGF1 in AD pathogenesis via MAPK, Ras, and FoxO signaling pathways, which might advance strategies for the prevention and therapy of AD based on IGF1 target.
A QoE Driven Cross-Domain Management Architecture for Space-Air-Ground Integrated Network
Authors: Tan Shihan , Jin Fenglin , Xie Jun , Dun Congying
Published: May 2022

With the increasing demands for networks, space-air-ground integrated network (SAGIN) and quality of experience (QoE) have been proposed in recent years. In order to adapt to the more complex network environment in the future, the network management based on QoE in SAGIN comes into being. In this paper, we propose a QoE driven cross-domain management architecture for SAGIN. From the perspective of systematicity, we focus on the process of the network management, including the required network functions, the distribution of different functions and the network operation strategy. Therefore, we divide the network architecture into subsystems, functional modules and network facilities, and propose the corresponding network operation strategies. In addition, we propose a network task allocation strategy based on Q-learning and apply it to the simulation environment of proposed architecture. Through simulation experiment, we demonstrate the advantages of QoE in SAGIN.
Design, Synthesis, and Antifungal Activity of Novel Benzimidazole Derivatives Bearing Thioether and Carbamate Moieties
Authors: Yang Lei
Published: May 2022

In this study, a series of benzimidazole derivatives bearing thioether and carbamate moieties have been synthesized and evaluated for their in vitro antifungal activity against Cytospora mandshurica, Thanatephorus cucumeris, Botrytis cinerea, Verticillium daliae, Phytophthora infestans, and Gibberella zeae by the mycelium growth rate method. The result of bioassay demonstrated that most of the compounds had certain antifungal activity. Especially, compound E11 revealed better antifungal activity against Verticillium daliae and Phytophthora infestans at 50 μg/mL, with the inhibition rates of 70% and 75%, respectively, than those of albendazole (38% and 61%, respectively). To the best of our knowledge, it is the first study on the synthesis and antifungal activity of benzimidazole derivatives containing thioether and carbamate moieties.
Methicillin-Resistant Staphylococcus aureus: Docking-Based Virtual Screening and Molecular Dynamics Simulations to Identify Potential Penicillin-Binding Protein 2a Inhibitors from Natural Flavonoids
Authors: Masumi Motahareh , Noormohammadi Fatemeh , Kianisaba Fatemeh , Nouri Fatemeh , Taheri Mohammad , Taherkhani Amir
Published: May 2022

Staphylococcus aureus (S. aureus) is responsible for several disorders including skin and soft tissue infections, bacteremia, pulmonary infections, septic arthritis, osteomyelitis, meningitis, gastroenteritis, toxic-shock syndrome, and urinary tract infections. Methicillin-resistant S. aureus (MRSA) contains penicillin-binding protein 2a (SauPBP2a) responsible for catalyzing the peptidoglycan production within the bacterial cell wall. The binding affinity of SauPBP2a to beta-lactam antibiotics is low, and thus, it is necessary to discover new effective SauPBP2a inhibitors to combat mortality and morbidity in patients affected by MRSA. The binding affinity of 46 natural flavonoids to the SauPBP2a active site was examined via molecular docking analysis. The stability of docked poses associated with the top-ranked flavonoids was tested by performing molecular dynamics (MD) in 10 nanoseconds (ns) computer simulations. Kaempferol 3-rutinoside-7-sophoroside and rutin demonstrated a considerable binding affinity to the SauPBP2a active site (Δ

G

binding < 

−

11 kcal/mol). Their docked poses were found to be stable for 10 ns MD simulations. Kaempferol 3-rutinoside-7-sophoroside and rutin also exhibited salient binding affinity to the enzyme’s allosteric site. This study suggests that kaempferol 3-rutinoside-7-sophoroside and rutin may be considered as drug candidates for therapeutic aims in several human infections associated with MRSA. Nevertheless, in vitro and in vivo confirmations are warranted.
A Novel Approach for Cyclic Decompositions of Balanced Complete Bipartite Graphs into Infinite Graph Classes
Authors: El-Mesady A. , Bazighifan Omar , Askar S. S.
Published: May 2022

Graph theory is considered an attractive field for finding the proof techniques in discrete mathematics. The results of graph theory have applications in many areas of social, computing, and natural sciences. Graph labelings and decompositions have received much attention in the literature. Several types of graph labeling were proposed for solving the problem of decomposing different graph classes. In the present paper, we propose a technique for labeling the vertices of a bipartite graph

G

with

n

edges, called orthogonal labeling, to yield cyclic decompositions of balanced complete bipartite graphs

K

n
,
n

by the graph

G

. By applying the proposed orthogonal labeling technique, we had constructed decompositions of

K

n
,
n

by paths, trees, one factorization, disjoint union of cycles, complete bipartite graphs, disjoint union of trees, caterpillars, and so forth. From the constructed results, we can confirm that the proposed orthogonal labeling technique is effective.
Developing a Framework for Managing Change Climate in Social Systems: Some Practical Implications for Medical Education Universities
Authors: Torkzadeh Jafar , Mohtaram Maasoumeh
Published: May 2022

This study is aimed at exploring a framework to develop change climate in social systems based on a strategic approach. The methodology of the case study was qualitative. The potential participations included managers and specialists of management at Shiraz University of Medical Sciences who were selected using the purposive sampling of standard type. Qualitative data were collected using semistructured interview with managers and specialists of change area in university and studying related top documents. To calculate the validity and reliability, the parallel processing method and the credibility and conformability of the study data were used. The results showed that the development of change climate in universities in the form of a model consisting of 38 basic themes, 10 organizing themes can be achieved. Based on this, some practical implications for medical universities have been inferred and expressed.
Neuroimaging Studies of Chronic Prostatitis/Chronic Pelvic Pain Syndrome
Authors: Zhao Yifan , Lin Jiaqi , Dong Ye , Tian Zilei , Ye Yan , Ma Ziyang , Xia Shengli , Huang Xiaopeng , Chen Diang , Zhang Peihai
Published: May 2022

Evidence shows that chronic prostatitis/chronic pelvic pain syndrome hugely impacts the body and mind. The central mechanisms in patients with CP/CPPS resulted in increased attention as neuroimaging techniques developed. This review investigated the study design and major neuroimaging findings in CP/CPPS patients to provide comprehensive evidence. Seven databases were searched and screened: PubMed, EMBASE/SCOPUS, Cochrane Library Database, China National Knowledge Infrastructure, VIP, Wanfang, and China Biology Medicine disc. Nine studies were eventually included in the analysis. The results demonstrate that the insula, anterior cingulate gyrus, postcentral gyrus, and precuneus are significantly associated with CP/CPPS patients’ pain feelings and cause dysregulation of painful emotions, lowering patients’ tolerance to stimulus.
Anti-HIV Drug Elvitegravir Suppresses Cancer Metastasis via Increased Proteasomal Degradation of m6A Methyltransferase METTL3
Authors: Liao Long , He Yan , Li Shu-Jun , Zhang Guo-Geng , Yu Wei , Yang Jing , Huang Zi-Jia , Zheng Can-Can , He Qing-Yu , Li Yan , Li Bin
Published: May 2022

N6-methyladenosine (m6A) methylation is an abundant modification in eukaryotic mRNAs. Accumulating evidence suggests a role for RNA m6A methylation in various aspects of cancer biology. In this study, we aimed to explore the biological role of RNA m6A modification in tumor metastasis and to identify novel therapeutic strategies for esophageal squamous cell carcinoma (ESCC). Integration of genome-wide CRISPR/Cas9 functional screening with highly invasive and metastatic ESCC subline models led to the identification of METTL3, the catalytic subunit of the N6-adenosine-methyltransferase complex, as a promoter of cancer metastasis. METTL3 expression was upregulated in ESCC tumors and metastatic tissues. In vitro and in vivo experiments indicated that METTL3 increased m6A in EGR1 mRNA and enhanced its stability in a YTHDF3-dependent manner, activating EGR1/Snail signaling. Investigation into the regulation of METTL3 expression found that KAT2A increased H3K27 acetylation levels in the METTL3 promoter region and activated transcription of METTL3, whereas SIRT2 exerted the opposite effects. Molecular docking and computational screening in a Food and Drug Administration–approved compound library consisting of 1,443 small molecules identified compounds targeting METTL3 to suppress cancer metastasis. Elvitegravir, originally developed to treat human immunodeficiency virus (HIV) infection, suppressed metastasis by directly targeting METTL3 and enhancing its STUB1-mediated proteasomal degradation. Overall, RNA m6A modifications are important in cancer metastasis, and targeting METTL3 with elvitegravir has therapeutic potential for treating ESCC.

Significance:

This study finds that METTL3 promotes cancer metastasis by activating EGR1/Snail signaling in an m6A-dependent manner, revealing vulnerability to METTL3 blockade in esophageal squamous cell carcinoma.