bluuebunny/crossref_metadata_2025 huggingface dataset:
Background Factors Affecting Visual Acuity at Initial Visit in Eyes with Central Retinal Vein Occlusion: Multicenter Study in Japan
Authors: Kondo Mineo , Noma Hidetaka , Shimura Masahiko , Sugimoto Masahiko , Matsui Yoshitsugu , Kato Kumiko , Saishin Yoshitsugu , Ohji Masahito , Ishikawa Hiroto , Gomi Fumi , Iwata Kensaku , Yoshida Shigeo , Kusuhara Sentaro , Hirai Hiromasa , Ogata Nahoko , Hirano Takao , Murata Toshinori , Tsuboi Kotaro , Kamei Motohiro , Kinoshita Takamasa , Kuwayama Soichiro , Hirano Yoshio , Ohta Manami , Kimura Kazuhiro , Takayama Kei , Takeuchi Masaru , Takamura Yoshihiro , Okamoto Fumiki , Mitamura Yoshinori , Terasaki Hiroto , Sakamoto Taiji , Group on behalf of Japan Clinical Retina Study (J-CREST)
Published: December 2021

Purpose: To determine the baseline characteristics of patients with central retinal vein occlusion (CRVO) that were significantly associated with the best-corrected visual acuity (BCVA) at the initial examination. Methods: This was a retrospective multicenter study using the medical records registered in 17 ophthalmological institutions in Japan. Patients with untreated CRVO (≥20-years-of-age) who were initially examined between January 2013 and December 2017 were studied. The patients’ baseline factors that were significantly associated with the BCVA at the initial examination were determined by univariate and multivariate linear regression analyses. Results: Data from 517 eyes of 517 patients were analyzed. Univariate analyses showed that an older age (r = 0.194, p < 0.001) and the right eye (r = −0.103, p < 0.019) were significantly associated with poorer BCVA at the initial visit. Multivariate analyses also showed that an older age (β = 0.191, p < 0.001) and the right eye (β = −0.089, p = 0.041) were significantly associated with poorer BCVA at the initial visit. Conclusions: The results indicate that an older age, a known strong factor, and the right eye were significantly associated with poorer BCVA at the initial visit to the hospital. These results suggest that functional and/or anatomical differences between the right and left eyes may be involved in these results.
Outcomes of Deceased Donor Kidney Transplantation in the Eurotransplant Senior Program with A Focus on Recipients ≥75 Years
Authors: Zompolas Ilias , Peters Robert , Liefeldt Lutz , Lehner Lukas J. , Budde Klemens , Ralla Bernhard , Goranova Irena , Maxeiner Andreas , Lerchbaumer Markus H. , Marticorena Garcia Stephan R. , Kanne Martin , Schlomm Thorsten , Schulz Matthias R. G. , Friedersdorff Frank
Published: December 2021

To evaluate the outcomes of kidney transplantations (KTs) in the Eurotransplant Senior Program (ESP) with a focus on the very old, defined as recipients ≥75 years. This retrospective clinical study included 85 patients, who under the ESP protocol underwent deceased donor kidney transplantation from January 2010 to July 2018 at the Charité–Universitätsmedizin Berlin in Germany. Recipients were divided in three age groups, i.e., Group 65–69, Group 70–74, Group ≥75, and compared. Prognostic risk factors for short and long-term outcomes of kidney transplantations were investigated. Graft survival at 1 and 5 years were respectively 90.7% and 68.0% for group 65–69, 88.9% and 76.2% for Group 70–74, and 100% and 71.4% for Group ≥75. Patient survival at 1 and 5 years were respectively 92.9% and 68.0% for Group 65–69, 85.7% and 61.5% for Group 70–74 and 100% and 62.5% for Group ≥75. Serum creatinine did not significantly differ between the three groups, with the exception of serum creatinine at 1 year. Increased recipient age and prolonged time on dialysis correlated with increased occurrence of postoperative complication. An increase in BMI, pretransplant diabetes mellitus and prolonged time on dialysis correlated with the occurrence of delayed graft function (DGF). History of smoking was identified as an independent risk factor for events of rejection. Increased human leukocyte antigen mismatches (HLA-MM) and prolonged cold ischemia time (CIT) correlated with higher rates of intensive care unit (ICU) treatment. This study supports kidney transplantations for the very old. End-stage renal disease (ESRD) patients ≥75 years of age who underwent kidney transplantation experienced comparable results to their younger counterparts. A comprehensive evaluation of ESRD patients with consideration of prognostic risk factor is the most suitable mean of identifying adequate kidney transplant candidates.
Therapeutic Drug Monitoring of Biologics in IBD: Essentials for the Surgical Patient
Authors: Nones Rodrigo Bremer , Fleshner Phillip R. , Queiroz Natalia Sousa Freitas , Cheifetz Adam S. , Spinelli Antonino , Danese Silvio , Peyrin-Biroulet Laurent , Papamichael Konstantinos , Kotze Paulo Gustavo
Published: December 2021

Despite significant development in the pharmacological treatment of inflammatory bowel diseases (IBD) along with the evolution of therapeutic targets and treatment strategies, a significant subset of patients still requires surgery during the course of the disease. As IBD patients are frequently exposed to biologics at the time of abdominal and perianal surgery, it is crucial to identify any potential impact of biological agents in the perioperative period. Even though detectable serum concentrations of biologics do not seem to increase postoperative complications after abdominal procedures in IBD, there is increasing evidence on the role of therapeutic drug monitoring (TDM) in the perioperative setting. This review aims to provide a comprehensive summary of published studies reporting the association of drug concentrations and postoperative outcomes, postoperative recurrence (POR) after an ileocolonic resection for Crohn’s disease (CD), colectomy rates in ulcerative colitis (UC), and perianal fistulizing CD outcomes in patients treated with biologics. Current data suggest that serum concentrations of biologics are not associated with an increased risk in postoperative complications following abdominal procedures in IBD. Moreover, higher concentrations of anti-TNF agents are associated with a reduction in colectomy rates in UC. Finally, higher serum drug concentrations are associated with reduced rates of POR after ileocolonic resections and increased rates of perianal fistula healing in CD. TDM is being increasingly used to guide clinical decision making with favorable outcomes in many clinical scenarios. However, given the lack of high quality data deriving mostly from retrospective studies, the evidence supporting the systematic application of TDM in the perioperative setting is still inconclusive.
Differences in the Buccal Bone Marrow Distance of ≤0.8 mm in the Mandible of Patients Undergoing Sagittal Split Ramus Osteotomy among the Different Skeletal Patterns: A Retrospective Study
Authors: Tseng Yu-Chuan , Liang Shih-Wei , Chou Szu-Ting , Chen Shih-Chieh , Pan Chin-Yun , Chen Chun-Ming
Published: December 2021

This study investigated the relationship between the thickness of the ramus and skeletal patterns using cone-beam computed tomography (CBCT) for sagittal split ramus osteotomy. Ninety participants were categorized into three skeletal patterns (Class I, Class II, and Class III). The first vertical slice (slice 0) was observed in the intact mandibular canal, and then moved forward to 40 mm (slice 21) with a 2 mm interval. The thickness of buccal bone marrow (B value) was measured. A B value of ≤0.8 mm was considered to be the major risk factor causing the occurrence of postoperative lower lip paresthesia. There were 461 sides with a B value of ≤0.8 mm. There was a significant difference in the skeletal patterns [Class III (198 sides: 15.7%) > Class I (159 sides: 12.6%) > Class II (104 sides: 8.3%)]. Class II participants had significantly larger B values (2.14 to 3.76 mm) and a lower occurrence rate (≤0.8 mm) than those of Class III participants (1.5 to 3 mm) in front of the mandibular foramen (from 6 mm to 20 mm). Class III participants had significantly shorter buccal bone marrow distance and a higher occurrence rate of B values (≤0.8 mm) than Class II.
Applications of Wearable Technology in a Real-Life Setting in People with Knee Osteoarthritis: A Systematic Scoping Review
Authors: Cudejko Tomasz , Button Kate , Willott Jake , Al-Amri Mohammad
Published: December 2021

With the growing number of people affected by osteoarthritis, wearable technology may enable the provision of care outside a traditional clinical setting and thus transform how healthcare is delivered for this patient group. Here, we mapped the available empirical evidence on the utilization of wearable technology in a real-world setting in people with knee osteoarthritis. From an analysis of 68 studies, we found that the use of accelerometers for physical activity assessment is the most prevalent mode of use of wearable technology in this population. We identify low technical complexity and cost, ability to connect with a healthcare professional, and consistency in the analysis of the data as the most critical facilitators for the feasibility of using wearable technology in a real-world setting. To fully realize the clinical potential of wearable technology for people with knee osteoarthritis, this review highlights the need for more research employing wearables for information sharing and treatment, increased inter-study consistency through standardization and improved reporting, and increased representation of vulnerable populations.
Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France
Authors: Volff Maxime , Tonon David , Bommel Youri , Peres Noémie , Lagier David , Agard Geoffray , Jacquier Alexis , Bartoli Axel , Carvelli Julien , Max Howard , Simeone Pierre , Blasco Valery , Pastene Bruno , Loundou Anderson , Boyer Laurent , Leone Marc , Velly Lionel , Bourenne Jeremy , Boussen Salah , Bobot Mickaël , Bruder Nicolas
Published: December 2021

Objectives: To describe clinical characteristics and management of intensive care units (ICU) patients with laboratory-confirmed COVID-19 and to determine 90-day mortality after ICU admission and associated risk factors. Methods: This observational retrospective study was conducted in six intensive care units (ICUs) in three university hospitals in Marseille, France. Between 10 March and 10 May 2020, all adult patients admitted in ICU with laboratory-confirmed SARS-CoV-2 and respiratory failure were eligible for inclusion. The statistical analysis was focused on the mechanically ventilated patients. The primary outcome was the 90-day mortality after ICU admission. Results: Included in the study were 172 patients with COVID-19 related respiratory failure, 117 of whom (67%) received invasive mechanical ventilation. 90-day mortality of the invasively ventilated patients was 27.4%. Median duration of ventilation and median length of stay in ICU for these patients were 20 (9–33) days and 29 (17–46) days. Mortality increased with the severity of ARDS at ICU admission. After multivariable analysis was carried out, risk factors associated with 90-day mortality were age, elevated Charlson comorbidity index, chronic statins intake and occurrence of an arterial thrombosis. Conclusion: In this cohort, age and number of comorbidities were the main predictors of mortality in invasively ventilated patients. The only modifiable factor associated with mortality in multivariate analysis was arterial thrombosis.
Angiographic Characteristics and Outcomes of Percutaneous Coronary Intervention of Reattempted Chronic Total Occlusion: Potential Contributing Factors to Procedural Success
Authors: Mohandes Mohsen , Moreno Cristina , Fuertes Mónica , Rojas Sergio , Pernigotti Alberto , Zambrano Diego , Guillén Marta , Guarinos Jordi , Bardají Alfredo
Published: December 2021

This study aimed to analyze angiographic characteristics of new attempted percutaneous coronary intervention (PCI) on chronic total occlusion (CTO) compared to first attempt group. The cohort of 527 CTO-PCIs was divided into first-attempt and re-attempt groups, and angiographic characteristics, level of complexity, and contributing factors to failure were analyzed. Between-group success rate difference and potential angiographic and technical aspects contributing to the success in new attempts were scrutinized. A total of 47 new PCIs in 39 patients were performed. The reattempt group showed higher J-CTO score compared to the first-attempt group (2.4 ± 1.06 vs. 1.2 ± 1.06; p < 0.001). The use of more complex techniques and devices such as retrograde approach (29.8% vs. 12.9%) and IVUS (48.9 vs. 27.3%; p: 0.002) were more frequent in the reattempt group. Both procedural and fluoroscopy time were higher in the reattempt group (197 ± 83.9 vs. 150.1 ± 72.3 and 97.7 ± 55.4 vs. 68.7 ± 43, respectively; p < 0.001). There was no between-group difference in terms of technical success (79.8 vs. 76.6% for first attempt vs. reattempt group, respectively; p: 0.6). The overall success rate increased by 6.1%, achieving 85.9% in the entire cohort. Reattempted CTO-PCIs required more complex techniques and had comparable technical success rate with regard to the first-attempt group.
Obesity and Uncontrolled Diabetes Predict Depression in HF Patients
Authors: Fetahu Albenita , Rrustemi Kaltrinë , Henein Michael Y. , Bytyçi Besim , Mehmeti Flamure , Bytyçi Ibadete , Kamberi Lulzim
Published: December 2021

Background and aim: Heart failure (HF) is a clinical syndrome associated with poor quality of life and prognosis, and premature mortality. The aim of this study was to assess the prevalence of depression and its risk factors in HF patients. Methods: The study included 151 HF patients (mean age of 66.6 ± 11 years, 52.3% female). Based on ejection fraction (EF), the study cohort was divided into the following two groups: group-I: HFpEF patients (EF ≥ 50%, n = 47) and group-II: HFrEF patients (EF < 40%, n = 104). For the enrolled patients, demographic, clinic and echocardiographic indices, and depression scale results were collected. Results: The patients with HF and depression were older, mostly females, more obese, and had a higher glycemic level and higher NYHA functional class compared with the patients without depression (p < 0.05 for all). The left ventricle (LV) and left atrial (LA) dimensions were larger, and EF was lower, in patients with depression compared to those without depression (p < 0.05 for all), while the right ventricle (RV) measurements did not differ (p > 0.05). The same parameters remained significantly different when the patients were divided into HFpEF and HFrEF. The depression scale correlated with glycemic level (r = 0.51, p = 0.01), obesity (rpb = 0.53, p = 0.001), age (r = 0.47, p = 0.02), and severity of NYHA class (rpb = 0.54, p = 0.001). On a multivariate model, BMI ≥ 30 kg/m2, OR 1.890 (1.199 to 3.551; 0.02) glycemic level ≥ 8.5 mmol/L, OR 2.802 (1.709 to 5.077; p = 0.01), and NYHA class > 2, OR 2.103 (1.389 to 4.700; p = 0.01), proved to be the most powerful independent predictors of depression, in the group as a whole. Obesity and uncontrolled diabetes predicted depression, irrespective of EF. Conclusions: In this modest cohort of HF patients, obesity and uncontrolled diabetes were independent predictors of depression, irrespective of LV systolic function. This emphasizes the important role of medical education for better control of such risk factors.
BMI Specific Complications Following Implant-Based Breast Reconstruction after Mastectomy
Authors: Leitner Helena Sophie , Pauzenberger Reinhard , Ederer Ines Ana , Radtke Christine , Hacker Stefan
Published: December 2021

Background: Breast reconstruction has a positive impact on body image and quality of life for women after experiencing the physically and psychologically demanding process of mastectomy. Previous studies have presented body mass index (BMI) as a predictor for postoperative complications after breast reconstruction, however, study results vary. This retrospective study aimed to investigate the impact of patients’ BMI on postoperative complications following implant-based breast reconstruction. Methods: All implant-based breast reconstructions performed at the Department of Plastic, Reconstructive and Aesthetic Surgery at the Medical University of Vienna from January 2001 to March 2018 were evaluated. A total of 196 reconstructed breasts among 134 patients met eligibility criteria. Demographic data, surgical techniques, as well as major and minor complications within a one-year follow-up period were analyzed. Results: Patients’ BMI did not show a significant impact on complication rates. The overall incidence of postoperative complications was 30.5% (40/131) of which 17.6% required reoperation. Impaired wound healing (18.3%), seroma (6.1%), hematoma (4.6%), capsular contraction (4.6%) and infection (3.8%) were the most common complications. Conclusion: In our study cohort, BMI was not associated with a significantly higher risk of complications. However, postoperative complications significantly increased with a longer operative time and resulted in an extended length of hospital stay.
How to Maintain Safety and Maximize the Efficacy of Cardiopulmonary Resuscitation in COVID-19 Patients: Insights from the Recent Guidelines
Authors: Chojecka Dominika , Pytlos Jakub , Zawadka Mateusz , Andruszkiewicz Paweł , Szarpak Łukasz , Dzieciątkowski Tomasz , Jaguszewski Miłosz Jarosław , Filipiak Krzysztof Jerzy , Gąsecka Aleksandra
Published: December 2021

Since December 2019, the novel coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has remained a challenge for governments and healthcare systems all around the globe. SARS-CoV-2 infection is associated with increased rates of hospital admissions and significant mortality. The pandemic increased the rate of cardiac arrest and the need for cardiopulmonary resuscitation (CPR). COVID-19, with its pathophysiology and detrimental effects on healthcare, influenced the profile of patients suffering from cardiac arrest, as well as the conditions of performing CPR. To ensure both the safety of medical personnel and the CPR efficacy for patients, resuscitation societies have published modified guidelines addressing the specific reality of the COVID-19 pandemic. In this review, we briefly describe the transmission and pathophysiology of COVID-19, present the challenges of CPR in SARS-CoV-2-infected patients, summarize the current recommendations regarding the algorithms of basic life support (BLS), advanced life support (ALS) and pediatric life support, and discuss other aspects of CPR in COVID-19 patients, which potentially affect the risk-to-benefit ratio of medical procedures and therefore should be considered while formulating further recommendations.
Role of Rendezvous-Procedure in the Treatment of Complications after Laparoscopic Sleeve Gastrectomy
Authors: Wichmann Dörte , Scheble Veit , Fusco Stefano , Schweizer Ulrich , Hönes Felix , Klingert Wilfried , Königsrainer Alfred , Archid Rami
Published: December 2021

Introduction: Laparoscopic sleeve gastrectomy is one of the most commonly performed bariatric procedures worldwide with good results, high patient acceptance, and low complication rates. The most relevant perioperative complication is the staple line leak. For the treatment of this complication, endoscopic negative pressure therapy has proven particularly effective. The correct time to start endoscopic negative pressure therapy has not been the subject of studies to date. Methods: Twelve patients were included in this retrospective data analysis over three years. Endoscopic negative pressure therapy was carried out using innovative open pore suction devices. Patients were treated with simultaneous surgery and endoscopy, so called rendezvous-procedure (Group A) or solely endoscopically, or in sequence surgically and endoscopically (Group B). Therapy data of the procedures and outcome measures, including duration of therapy, therapy success, and change of treatment strategy, were collected and analysed. Results: In each group, six patients were treated (mean age 52.96 years, 4 males, 8 females). Poor initial clinical situation, time span of endoscopic negative pressure therapy (Group A 31 days vs. Group B 18 days), and mean length of hospital stay (Group A 39.5 days vs. Group B 20.17 days) were higher in patients with rendezvous procedures. One patient in Group B died during the observation time. Discussion: Rendezvous procedures for patients with staple line leaks after sleeve gastrectomy is indicated for serious ill patients with perigastric abscesses and in need of laparoscopic lavage. The one-stage complication management with the rendezvous procedure seems not to result in an obvious advantage in the further outcome in patients with staple line leaks after laparoscopic sleeve gastrectomy.
Outcome of Elderly Patients with Venous Thromboembolism Treated with Direct Oral Anticoagulants—A Retrospective Cohort Study
Authors: Ayalon-Dangur Irit , Vega Yakov , Israel Miriam Rozi , Grossman Alon , Spectre Galia , Shochat Tzippy , Leibovici Leonard , Gafter-Gvili Anat
Published: December 2021

Introduction: Randomized controlled trials that compared direct oral anticoagulants (DOACs) to vitamin K antagonists (VKA) for the treatment of venous thromboembolism (VTE), demonstrated both efficacy and safety of DOACs. The aim of the current study was to compare DOACs to VKA for the treatment of VTE in the elderly, in a real-life setting. Methods: A retrospective cohort study was performed in Rabin Medical Center encompassing a 7-year period. Hospitalized patients >65 years, with a diagnosis of VTE discharged with DOACs or VKA were included. The primary outcome was a composite of all-cause mortality, major bleeding, recurrent VTEs and hospitalizations throughout the follow-up period of one year. Results: A total of 603 patients were included in the final analysis. The mean age was 79.6 ± 8.5 years. The primary composite outcome occurred in 74.6% and 56.7% of the patients in the VKA group and DOACs group, respectively, hazard ratio 0.59, 95% confidence interval 0.46 to 0.76, in favor of the DOACs group. In a matched cohort analysis, the results were the same as the original analysis. Conclusion: In the elderly population, treatment of VTE with DOACs was associated with a lower rate of the composite outcome. DOACs are safe and effective for elderly patients with VTE.
Design of In-Memory Parallel-Prefix Adders
Authors: Reuben John
Published: December 2021

Computational methods in memory array are being researched in many emerging memory technologies to conquer the ‘von Neumann bottleneck’. Resistive RAM (ReRAM) is a non-volatile memory, which supports Boolean logic operation, and adders can be implemented as a sequence of Boolean operations in the memory. While many in-memory adders have recently been proposed, their latency is exorbitant for increasing bit-width (O(n)). Decades of research in computer arithmetic have proven parallel-prefix technique to be the fastest addition technique in conventional CMOS-based binary adders. This work endeavors to move parallel-prefix addition to the memory array to significantly minimize the latency of in-memory addition. Majority logic was chosen as the fundamental logic primitive and parallel-prefix adders synthesized in majority logic were mapped to the memory array using the proposed algorithm. The proposed algorithm can be used to map any parallel-prefix adder to a memory array and mapping is performed in such a way that the latency of addition is minimized. The proposed algorithm enables addition in O(log(n)) latency in the memory array.
High Levels of Tetrodotoxin in the Flesh, Usually an Edible Part of the Pufferfish Takifugu flavipterus, Caused by Migration from the Skin and the Regional Characteristics of Toxin Accumulation
Authors: Oshiro Naomasa , Kuniyoshi Kyoko , Yamamoto Shigeyoshi , Hotta Ayano , Yamada Takuma , Suzuki Takafumi , Sugita Noriko , Matsuura Keiichi , Nakashima Akie , Anzai Yoichi , Asakura Hiroshi
Published: December 2021

The consumption of a pufferfish, Takifugu flavipterus or komonfugu in Japanese, formerly known as Takifugu poecilonotus, is popular in Japan. However, T. flavipterus is frequently involved in cases of tetrodotoxin (TTX) poisoning in Japan. Although victims have usually consumed inedible parts, some cases are related to consumption of flesh. To improve the risk management of pufferfish poisoning, we studied TTX level in the flesh and skin of T. flavipterus. Ninety-seven specimens obtained from the Seto Inland Sea and landed in Fukuoka Prefecture were analyzed by liquid chromatography-tandem mass spectrometry. The flesh from six specimens was toxic (>10 MU/g = 2.2 mg/kg): one was in poor condition (not freeze–thawed); three were freeze–thawed before sample preparation; and two freshly prepared and in good condition (not freeze–thawed). The fillets were divided into outer and inner portions; the TTX levels in the outer portions were notably higher. The skin of the six specimens was moderately to extremely toxic: 165 MU/g (36.3 mg/kg) in the fresh specimen not in good condition, 600–950 MU/g (132–200 mg/kg) in freeze–thawed specimens, and 4500 and 6000 MU/g (990 and 1320 mg/kg) in the two fresh specimens. We concluded that TTX in the flesh migrated from the highly toxic skin. In addition, TTX levels in the skin appeared to be regionally specific. We recommend that toxic portions of T. flavipterus are removed as soon as possible after individuals are caught, and that fish from known highly toxic areas are not consumed.
Gird Based Line Segment Detector and Application: Vision System for Autonomous Ship Small Assembly Line
Authors: Ding Jinhong , Ni Chongben
Published: December 2021

The shipbuilding industry demands intelligent robot, which is capable of various tasks without laborious pre-teaching or programming. Vision system guided robots could be a solution for autonomous working. This paper introduces the principle and technique details of a vision system that guides welding robots in ship small assembly production. TOF sensors are employed to collect spatial points of workpieces. Huge data amount and complex topology bring great difficulty in the reconstruction of small assemblies. A new unsupervised line segment detector is proposed to reconstruct ship small assemblies from spatial points. Verified using data from actual manufacturing, the method of this paper demonstrated good robustness which is a great advantage for industrial applications. This paper’s work has been implemented in shipyards and shows good commercial potential. Intelligent, flexible industrial robots could be implemented with the findings of this study, which will push forward intelligent manufacturing in the shipbuilding industry.
Allometric Growth of Sargassum fusiforme (Ochrophyta, Fucales) Organs in the Maturation Period Based on Biomass Analysis of Samples from Gouqi Island
Authors: Li Xunmeng , Wang Kai , Chen Jianqu , Zhang Shouyu
Published: December 2021

Sargassum fusiforme is a seaweed species that plays an important role in the diverse communities of the flora and fauna of coastal food webs. Assessments of its biomass and energy allocation in addition to allometric organ growth have important ecological value for understanding the community structure, carbon storage, and resource assessment of seaweed beds during periods in which they thrive. In this study, the morphology of Sargassum fusiforme and the biomass of organs and total organisms in the maturation period were studied, and the allometric relationships for different organs of Sargassum fusiforme were analyzed using the standardized major axis (SMA). In the maturation period of Sargassum fusiforme, branch number, height × stem diameter were the prior independent variables, and the optimum biomass was y = 0.002x1.107 (R2 = 0.923). The biomass allocation ratio of blades was the highest (38.33%), followed by stems (32.90%) and receptacles (28.77%). The growth rates of the various organs were found to differ, and the rate of biomass increase for the blades and stems tended to converge. The rate of receptacle biomass growth of Sargassum fusiforme was the highest in the maturation period, and the rate of organ biomass increase was Wb < Ws < Wt < Wr, which reflects the trade-off with energy allocation as a strategy used by Sargassum fusiforme.
Impacts of Human Activities on Hydrodynamic Structures during the Dry Season in the Modaomen Estuary
Authors: Liu Changjie , Zhong Ziyue , Xiao Yiqing , Chen Xiaoqi , Yu Minghui
Published: December 2021

Over the past few decades, the topography and river-tide-salt dynamic characteristics of the Pearl River Delta (PRD) have undergone a myriad of changes due to the unnatural evolution process induced by diverse human activities, such as dam construction, land reclamation, sand excavation, and dredging for navigation. To investigate the impact of human activities on hydrodynamic structures in the PRD of the Modaomen Estuary (ME) during the dry season, a three-dimensional river-tide-salt dynamic model was used to simulate the hydrodynamic characteristics of the ME for different historical periods. The model results indicate that large-scale land reclamation weakened the tidal dynamics and mixing effects in the ME, promoting gravity circulation with opposite velocity directions at the surface and bottom within 15 km downstream of the estuary. Additionally, riverbed downcutting enhanced the tidal dynamics, which intensified saltwater intrusion, leading to the spatial scale-of-gravity circulation expanding 1–2 times. The enhancement of riverbed downcutting on the tidal dynamics in the ME was significantly greater than the weakening effect of land reclamation. Hence, due to the comprehensive influence of human activities between the 1970s and 2010, the hydrodynamic structures in the ME changed from a state of atypical gravity circulation, with nonobvious stratification, to a state of highly stratified and large-scale gravity circulation. The pollutant diffusion in the ME under different scenarios is also discussed in this paper. The results show that reclamation results in weakening of tidal dynamics, which is not conducive to the mixing and diffusion of pollutants in the estuary. However, the narrowed estuary due to land reclamation is conducive to the rapid entry of pollutants into the open sea.
Oncholaimus tripapillatus sp. nov., a New Free-Living Marine Nematode of the Genus Oncholaimus Dujardin, 1845 (Nematoda: Enoplida: Oncholaimidae) from the Subtidal Sediment of Dokdo Island, East Sea, Korea, with a New Record of O. qingdaoensis Zhang & Platt, 1983
Authors: Lee Hyojin , Lee Heegab , Rho Hyunsoo
Published: December 2021

During a survey of the free-living marine nematodes of Korea, two species belonging to the genus Oncholaimus Dujardin, 1845 were discovered. A new species, Oncholaimus tripapillatus sp. nov. and a newly recorded species, Oncholaimus qingdaoensis Zhang & Platt, 1983, are reported. Oncholaimus tripapillatus sp. nov. was collected from the washing of subtidal coarse sediments around Dokdo Island of the East Sea, Korea. Oncholaimus tripapillatus sp. nov. is characterized by a relatively long (4071–4435 µm in males and 4514–4661 µm in females) and slender body, a slightly constricted head region, relatively long cephalic setae (10–12 µm), males having a precloacal sexual protuberance bearing two small cone-shaped supplementary spines, five pairs of long cloacal setae (three pairs of precloacal and two pairs of postcloacal setae in subventral position), and three remarkable papillae near the end of the tail, with two pairs of subventral setae. The Korean specimens of Oncholaimus qingdaoensis Zhang & Platt, 1983 are almost identical to the Chinese specimens of the original description from the intertidal sand of Qingdao, China. However, the Korean specimens differ from the Chinese specimens in the longer body length in males (3379–3715 µm vs. 2380–2640 µm), the larger spicule length (47–52 µm vs. 34–36 µm), and the presence of ventral tail papillae situated around 14–16 µm from the tail tip. Detailed morphological features and illustrations of two Oncholaimus species from Korea were obtained by differential interference contrast microscopy and scanning electron microscopy. A pictorial key to the species group with distinct tail papillae among the genus Oncholaimus is also provided.
A Novel Feature-Based Detector for Underwater Acoustic Beacon Signals Using Superimposed Envelope Spectrum of Multi-Pulses
Authors: Yao Shuai , Liu Yinjia
Published: December 2021

For tackling the challenge of in-time searching a sea-crashed plane, it is critical to develop a convenient and reliable detector for the underwater beacon signal. In the application of signal detection, a conventional detector such as linear correlation (LC) is used based on the assumption of Gaussian white noise, but it has turned out to be a poor choice in a sophisticated underwater environment. To address this issue, a novel feature-based detector using superimposed envelope spectrum (SES) of multi-pulses is proposed in this paper. The proposed detector firstly extracts the envelopes of the received multi-pulse signals and superimposes the envelopes according to the known period. Then, the harmonic features of the SES are derived and utilized in the feature judgment to make the final decision. The proposed method is evaluated together with several existing state-of-the-art detectors, including the matched filter (MF), the generalized likelihood ratio test (GRLT) detector, and the periodogram of the directly dislocation superposition (PDDS) detectors with constant false alarm probability. Compared with the conventional detectors, it is found that the proposed SES detector is more robust against the colored noise, the random phase, and the channel distortions caused by the sophisticated underwater environment. Simulation results show that, given a detection probability value of 90% and a false alarm probability value of 1%, the proposed detector shows a gain of 3–12 dB compared with the best one of the MF, GRLT, and the PDDS detectors under distorted channels in terms of signal-to-noise ratio (SNR) requirements, respectively. Experimental results based on lake trial data have also verified the validity and feasibility of the proposed feature-based detector.
Distribution of Nereilinum murmanicum (Annelida, Siboglinidae) in the Barents Sea in the Context of Its Oil and Gas Potential
Authors: Karaseva Nadezda , Kanafina Madina , Gantsevich Mikhail , Rimskaya-Korsakova Nadezhda , Zakharov Denis , Golikov Alexey , Smirnov Roman , Malakhov Vladimir
Published: December 2021

Frenulate siboglinids are a characteristic component of communities living in various reducing environments, including sites with hydrocarbon seeps. High concentrations of hydrocarbons in the sediments of the Arctic basin seas, including the Barents Sea, suggest the presence of a rich siboglinid fauna there. This reflects the fact that microbiological oxidation of methane occurs under reducing conditions, generating high concentrations of hydrogen sulfide in the sediment. This hydrogen sulfide acts as an energy source for the sulfide-oxidizing symbionts of siboglinids. Here we report on the findings of the frenulate siboglinid species Nereilinum murmanicum made between 1993 and 2020 in the Barents Sea. These data significantly expand the range of this species and yield new information on its habitat distribution. The depth range of N. murmanicum was 75–375 m. The species was most abundant from 200 to 350 m and was associated with temperatures below 3 °C and salinities from 34.42 to 35.07. Most of the findings (43 locations or 74%) fall on areas highly promising for oil and gas production. Twenty-eight locations (48%) are associated with areas of known oil deposits, 22 locations (37%) with explored areas of gas hydrate deposits. N. murmanicum was also found near the largest gas fields in the Barents Sea, namely Shtokman, Ludlovskoye and Ledovoye.
Mackerel (Scomber australasicus) Reproduction in Northeastern Taiwan
Authors: Sinaga Sunarti , Lu Hsueh-Jung , Lin Jia-Rong
Published: December 2021

Blue mackerel (Scomber australasicus) is a crucial target species for coastal fisheries in Taiwan, and additionally it has maintained its status as the highest-produced species. The timely measurement of spawning status is crucial for determining the correct management strategy for this species. The objective of this study was to determine size at maturity, fecundity, batch fecundity, and spawning frequency on the basis of samples collected from Nan-Fang-Ao fishing port in Yilan, during the spawning season from 2017 to 2019. Histological sections indicated that the blue mackerel were multiple spawners; a higher percentage of female fish spawned at the peak of the gonadosomatic index. The 50% sizes at maturity were 32.02, 32.13, and 29.64 cm. Mean total fecundity (batch fecundity) was 165 (103), 229 (96), and 210 (68) oocytes per ovary-free weight (g) for 2017, 2018, and 2019, respectively; fecundity was determined through observation of postovulatory follicles (POFs). The spawning frequencies (spawning fraction) in 2017, 2018, and 2019 were 3–10 days (0.13), 4–14 days (0.08), and 4–12 days (0.09), respectively. The spawning frequencies determined through the three estimated methods, namely the sums of (a) hydrated and Day 0 POFs; (b) Day 1+ POFs, and (c) all data combined, were 1 spawning event per 8, 10, and 9 days, respectively. The reproduction of the blue mackerel was greater in 2017 than it was in 2018 or 2019, as indicated by the higher batch fecundity and shorter spawning seasons. Environmental factors should also be considered as a major factor influencing successful reproduction and spawning season
Development of a Datalogger for Submarine Glider: Integration of Fault-Tolerant Software Layers
Authors: De León-Gordillo Dagoberto , Rodríguez-Olivares Noé Amir , Barriga-Rodríguez Leonardo , Sánchez-Gaytán José Luis , Soto-Cajiga Jorge Alberto , Ronquillo-Lomelí Guillermo , Salgado-Jiménez Tomás
Published: December 2021

Submarine gliders are specialized systems used in applications such as environmental monitoring of marine fauna, in the oil industry, among others. The glider launch and capture is a costly process that requires substantial technological and human resources, so the orderly and error-free storage of data is of fundamental importance due to the subsequent analysis. The amount of information being obtained from the seabed is increasing, this leads to the need to develop robust and low-cost ad-hocsystems for this type of application. The challenge is the integration of the different software layers in the storage system because the monitored variables must be ordered according to different glider operations such as calibration data update and navigation. Additionally, to avoid data corruption in the memory chip, error control coding must be used. The goal of this paper is to present a novel design of different layers of software integrated into a datalogger: reception, error control, and storage logic for the different glider operations. The design of the datalogger is based on a NAND flash memory chip and an MSP430 microcontroller. To correct bit-flipping errors, a BCH code that corrects 4 errors for every 255 bits is implemented into the microcontroller. The design and evaluation are performed for different glider operations, and for different lengths and correction capabilities of the BCH module. A test to calculate the storage time has been carried out. This test shows that in the case of 256 bytes per sample, at 30 samples per minute, and 1 GB of storage capacity, it is possible to collect data from the glider sensors for 84 days. The results obtained show that our device is a useful option for storing underwater sensor data due to its real-time storage, power consumption, small size, easy integration, and its reliability, where the bit error rate BER is of 2.4 ×10−11.
Application of Feature Point Matching Technology to Identify Images of Free-Swimming Tuna Schools in a Purse Seine Fishery
Authors: Hou Qinglian , Zhou Cheng , Wan Rong , Zhang Junbo , Xue Feng
Published: December 2021

Tuna fish school detection provides information on the fishing decisions of purse seine fleets. Here, we present a recognition system that included fish shoal image acquisition, point extraction, point matching, and data storage. Points are a crucial characteristic for images of free-swimming tuna schools, and point algorithm analysis and point matching were studied for their applications in fish shoal recognition. The feature points were obtained by using one of the best point algorithms (scale invariant feature transform, speeded up robust features, oriented fast and rotated brief). The k-nearest neighbors (KNN) algorithm uses ‘feature similarity’ to predict the values of new points, which means that new data points will be assigned a value based on how closely they match the points that exist in the database. Finally, we tested the model, and the experimental results show that the proposed method can accurately and effectively recognize tuna free-swimming schools.
A Comprehensive Evaluation of Cross-Omics Blood-Based Biomarkers for Neuropsychiatric Disorders
Authors: Song Weichen , Wang Weidi , Liu Zhe , Cai Wenxiang , Yu Shunying , Zhao Min , Lin Guan Ning
Published: December 2021

The identification of peripheral multi-omics biomarkers of brain disorders has long been hindered by insufficient sample size and confounder influence. This study aimed to compare biomarker potential for different molecules and diseases. We leveraged summary statistics of five blood quantitative trait loci studies (N = 1980 to 22,609) and genome-wide association studies (N = 9725 to 500,199) from 14 different brain disorders, such as Schizophrenia (SCZ) and Alzheimer’s Disease (AD). We applied summary-based and two-sample Mendelian Randomization to estimate the associations between blood molecules and brain disorders. We identified 524 RNA, 807 methylation sites, 29 proteins, seven cytokines, and 22 metabolites having a significant association with at least one of 14 brain disorders. Simulation analyses indicated that a cross-omics combination of biomarkers had better performance for most disorders, and different disorders could associate with different omics. We identified an 11-methylation-site model for SCZ diagnosis (Area Under Curve, AUC = 0.74) by analyzing selected candidate markers in published datasets (total N = 6098). Moreover, we constructed an 18-methylation-sites model that could predict the prognosis of elders with mild cognitive impairment (hazard ratio = 2.32). We provided an association landscape between blood cross-omic biomarkers and 14 brain disorders as well as a suggestion guide for future clinical discovery and application.
Pre-Treatment Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Predictors of Occult Cervical Metastasis in Clinically Negative Neck Supraglottic and Glottic Cancer
Authors: Salzano Giovanni , Perri Francesco , Maglitto Fabio , Togo Giulia , De Fazio Gianluca Renato , Apolito Michela , Calabria Federica , Laface Claudia , Vaira Luigi Angelo , Committeri Umberto , Balia Mario , Pavone Ettore , Aversa Corrado , Salzano Francesco Antonio , Abbate Vincenzo , Ottaiano Alessandro , Cascella Marco , Santorsola Mariachiara , Fusco Roberta , Califano Luigi , Ionna Franco
Published: December 2021

Background. Among patients with diagnosis of Laryngeal Squamous Cell Carcinoma (LSCC), up to 37.5% of cases may have occult metastasis (OM), and this feature is linked to poor prognosis and high rate of local recurrence. The role of elective neck dissection (END) in clinically negative neck (cN0) LSCC remains controversial. It is of great value to search for low-cost and easily detectable indicators to predict the risk of OM in laryngeal cancer. Recent reports have shown that high values of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) represent a negative prognostic factor in head and neck cancers. The aim of our study has been to investigate the value of pre-treatment NLR and PLR with regard to predicting occult cervical metastasis in cN0 supraglottic and glottic LSCC. Materials and methods. Data of patients affected by LSCC, who had been surgically treated by means of laryngectomy (total, horizontal partial and supracricoid) and END between January 2006 and January 2021, were retrospectively reviewed, using information retrieved from a database dedicated to such procedures in a single tertiary care referral institute. Results. A total of 387 patients were treated for LSCC at our Institute from 2006 to 2021, but only 108 of them met the inclusion criteria. The median age at the time of diagnosis was 64 years (range, 39–89 years). All the tumors were treated with a laryngectomy and an END. A total of 27.7% of patients were found positive for neck node metastasis (the pN+ group), while 78/108 (72.3%) patients were found to be negative for the presence of neck metastasis (the pN0 group). High values of NLR, but not PLR, significantly correlated with the probability of OM, and according to the iterative algorithm of Newton–Raphson, an NLR value of 2.26 corresponds to a probability of OM of 20%. Conclusion. Our analysis revealed a statistical correlation between high NLR pre-treatment values and positive neck OM in patients with LSCC.
Liver Enhancement on Computed Tomography Is Suboptimal in Patients with Liver Steatosis
Authors: van Cooten Véronique V. , de Jong Daan J. , Wessels Frank J. , de Jong Pim A. , Kok Madeleine
Published: December 2021

This study’s aim was twofold. Firstly, to assess liver enhancement quantitatively and qualitatively in steatotic livers compared to non-steatotic livers on portal venous computed tomography (CT). Secondly, to determine the injection volume of contrast medium in patients with severe hepatic steatosis to improve the image quality of the portal venous phase. We retrospectively included patients with non-steatotic (n = 70), the control group, and steatotic livers (n = 35) who underwent multiphase computed tomography between March 2016 and September 2020. Liver enhancement was determined by the difference in attenuation in Hounsfield units (HU) between the pre-contrast and the portal venous phase, using region of interests during in three different segments. Liver steatosis was determined by a mean attenuation of ≤40 HU on unenhanced CT. Adequate enhancement was objectively defined as ≥50 ΔHU and subjectively using a three-point Likert scale. Enhancement of non-steatotic and steatotic livers were compared and associations between enhancement and patient- and scan characteristics were analysed. Enhancement was significantly higher among the control group (mean 51.9 ± standard deviation 11.5 HU) compared to the steatosis group (40.6 ± 8.4 HU p for difference < 0.001). Qualitative analysis indicated less adequate enhancement in the steatosis group: 65.7% of the control group was rated as good vs. 8.6% of the steatosis group. We observed a significant correlation between enhancement, and presence/absence of steatosis and grams of iodine per total body weight (TBW) (p < 0.001; adjusted R2 = 0.303). Deduced from this correlation, theoretical contrast dosing in grams of Iodine (g I) can be calculated: g I = 0.502 × TBW for non-steatotic livers and g I = 0.658 × TBW for steatotic livers. Objective and subjective enhancement during CT portal phase were significantly lower in steatotic livers compared to non-steatotic livers, which may have consequences for detectability and contrast dosing.