bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of co-diagnostic effect genes for aortic dissection and metabolic syndrome by multiple machine learning algorithms
Authors: Zhang Yang , Li Jinwei , Chen Lihua , Liang Rui , Liu Quan , Wang Zhiyi
Published: September 2023

Aortic dissection (AD) is a life-threatening condition in which the inner layer of the aorta tears. It has been reported that metabolic syndrome (MS) has a close linkage with aortic dissection. However, the inter-relational mechanisms between them were still unclear. This article explored the hub gene signatures and potential molecular mechanisms in AD and MS. We obtained five bulk RNA-seq datasets of AD, one single cell RNA-seq (scRNA-seq) dataset of ascending thoracic aortic aneurysm (ATAA), and one bulk RNA-seq dataset of MS from the gene expression omnibus (GEO) database. Identification of differentially expressed genes (DEGs) and key modules via weighted gene co-expression network analysis (WGCNA), functional enrichment analysis, and machine learning algorithms (Random Forest and LASSO regression) were used to identify hub genes for diagnosing AD with MS. XGBoost further improved the diagnostic performance of the model. The receiver operating characteristic (ROC) and precision-recall (PR) curves were developed to assess the diagnostic value. Then, immune cell infiltration and metabolism-associated pathways analyses were created to investigate immune cell and metabolism-associated pathway dysregulation in AD and MS. Finally, the scRNA-seq dataset was performed to confirm the expression levels of identified hub genes. 406 common DEGs were identified between the merged AD and MS datasets. Functional enrichment analysis revealed these DEGs were enriched for applicable terms of metabolism, cellular processes, organismal systems, and human diseases. Besides, the positively related key modules of AD and MS were mainly enriched in transcription factor binding and inflammatory response. In contrast, the negatively related modules were significantly associated with adaptive immune response and regulation of nuclease activity. Through machine learning, nine genes with common diagnostic effects were found in AD and MS, including MAD2L2, IMP4, PRPF4, CHSY1, SLC20A1, SLC9A1, TIPRL, DPYD, and MAPKAPK2. In the training set, the AUC of the hub gene on RP and RR curves was 1. In the AD verification set, the AUC of the Hub gene on RP and RR curves were 0.946 and 0.955, respectively. In the MS set, the AUC of the Hub gene on RP and RR curves were 0.978 and 0.98, respectively. scRNA-seq analysis revealed that the SLC20A1 was found to be relevant in fatty acid metabolic pathways and expressed in endothelial cells. Our study revealed the common pathogenesis of AD and MS. These common pathways and hub genes might provide new ideas for further mechanism research.
In vitro efficacy of synthetic lawsone derivative disinfectant solution on removing dual-species biofilms and effect on acrylic denture surface properties
Authors: Manuschai Jutharat , Lomlim Luelak , Ratti Pichayaporn , Kara Jiraporn , Naorungroj Supawadee
Published: September 2023

Candida albicans (C. albicans) and Streptococcus mutans (S. mutans) biofilms involve in denture stomatitis. This study compared compound 1 to 2% chlorhexidine gluconate (CHX), Polident, and distilled water (DW) in biofilms reduction and effect on polymethylmethacrylate acrylic (PMMA) properties. The structure of lawsone (naphthoquinone derivative) was modified by the addition of an alkylnyloxy group to yield compound 1. Dual-species biofilms of C. albicans and S. mutans were developed on PMMA discs. The colony-forming unit count measured the number of residual biofilm cells after exposure to the test agents. PMMA discs were examined for color stability, surface roughness, hardness, and chemical structure after 28 days. At 3 min, compound 1 was less effective than CHX in reducing C. albicans (p = 0.004) and S. mutans (p = 0.034) but more effective than Polident in reducing C. albicans (p = 0.001). At 15 min, no viable cells were detectable for compound 1 and its effectiveness was comparable to CHX (p = 0.365). SEM showed fungal cell surface damages in CHX, compound 1 and Polident groups. Only color change was affected by time (p < 0.001) and type of test agent (p = 0.008), and only CHX reached a clinical perception level. Compound 1 is a promising agent for removing biofilm from the PMMA surface without substantially degrading surface properties.
Analysis of clinical features and identification of risk factors in patients with non-alcoholic fatty liver disease based on FibroTouch
Authors: Liao Yan , Liu Lei , Yang Jiayao , Zhou Xiaoli , Teng Xiaoli , Li Yixi , Wan Ying , Yang Jian , Shi Zhaohong
Published: September 2023

Our aim was to explore the correlation between ultrasound attenuation parameter (UAP) and liver stiffness measurement (LSM) based on FibroTouch (China) and clinical features in patients with non-alcoholic fatty liver disease (NAFLD), so as to provide a certain basis for the clinical application of FibroTouch in NAFLD. Hepatic steatosis and fibrosis in patients with NAFLD were graded according to FibroTouch, and the relationship between steatosis and fibrosis levels and clinical characteristics was retrospectively analyzed. Hepatic steatosis was positively related with weight, BMI, waist, hyperlipidemia, hyperuricemia, FBG, UA, TG, ALT, AST, GGT, LSM and hepatic fibrosis grading, and was negatively related with gender (male), age and AST/ALT ratio. Hepatic fibrosis was positively related with age, BMI, waist, hypertension, FBG, ALT, AST, GGT, NFS, APRI, FIB-4, UAP and hepatic steatosis grading, and was negatively related with blood platelet (PLT) counts. Moreover, BMI, waist, TG, ALT and LSM were independent risk factors of hepatic steatosis, while decreased PLT counts, AST and UAP were independent risk factors of hepatic fibrosis. Body mass parameters, metabolic risk factors and liver function indicators increase the risk of hepatic steatosis and fibrosis in patients with NAFLD, and UAP and LSM can interact with each other.
Neoadjuvant chemotherapy reduces the levels of HMGB1 and E-cadherin in patients with breast cancer
Authors: Su Qingchang , Wang Xin , Zhu Rongchen , Liu Cuicui , Sun Shanping
Published: September 2023

This study investigated the changes in serum tumor marker levels in patients with breast cancer (BC) after neoadjuvant chemotherapy (NACT) and their potential as prognostic factors in NACT. A total of 134 consecutive patients with BC treated at our hospital between January 2019 and December 2021 were retrospectively analyzed. Patients were treated with NACT based on the docetaxel, epirubicin, and cyclophosphamide (TEC) regimen and assessed for marker levels, T cell subsets, and therapeutic outcomes. Receiver operating characteristic (ROC) curves were constructed to evaluate the predictive performance of the markers. Outcome assessments showed that NACT effectively reduced the tumor size, leading to increased complete remission, partial remission, stable disease, and significantly reduced disease progression. Improved immune function has also been observed after NACT. The levels of two (E-cadherin and HMGB1) out of five markers (CA153, CK19, CEA, E-cadherin, and HMGB1) were significantly reduced after NACT before surgery compared with those at admission, suggesting that NACT modulates the levels of biomarkers. ROC analysis revealed that the area under the curve (AUC) of HMGB1 and E-cadherin combination was 0.87 for discrimination of therapeutic response with a sensitivity and specificity of 91.3% and 88.4%, respectively. Serum tumor marker levels were reduced after NACT in patients with BC. The reduction was most prominent for HMGB1, followed by E-cadherin. These biomarkers can be used to predict the therapeutic response to NACT with an AUC of 0.87, thus offering a new tool to monitor treatment progress in NACT for patients with BC.
A study of allergen detection panel in Guangzhou, southern China based on real-world data from the past 7 years
Authors: Hu Haisheng , Huang Huimin , Liao Chenxi , Li Aoli , Zhang Teng , Liang Xueqing , Sun Baoqing
Published: September 2023

This study aims to reduce the cost of allergen testing for Guangzhou, China by limiting the number of allergens for which patients are tested, and provide a testing panel to improve diagnostic and therapeutic efficiency. This retrospective study of real-world data from 2012 to 2019 included 39,570 patients with suspected allergies in Guangzhou, southern China. All the patients were tested for one or more of the following allergens serum specific immunoglobulin E (sIgE): Dermatophagoides pteronyssinus, Dermatophagoides farinae, cat dander, dog dander, Artemisia vulgaris, Aspergillus fumigatus, Alternaria alternata, Blattella germanica, egg whites, milk, wheat, peanuts, soybeans, Cancer pagurus, and Penaeus monodon by PhadiaCAP 1000. Totally, only the positive rates of allergens sIgE in D. farinae, D. pteronyssinus, milk, egg whites, B. germanica, C. pagurus, A. alternata, and P. monodon were > 10%, the other allergens were between 4–7%. Moreover, among the allergic diseases, dust mites exhibited the overall highest positive rate, followed by milk and B. germanica. In children, milk was the main allergen, whereas in adults, mites, cockroaches, shrimp, and crab allergens had higher positive rates. The optimal scale analysis shows that the multiple sensitization classification of patients can be divided into three categories: I D. farinae and D. pteronyssinus; II. C. pagurus, P. monodon, and B. germanica; III. Milk and egg whites. Generally, a panel including 4 allergens can detect > 90% of the potential allergy in this local population. In Guangzhou, southern China, D. farinae, milk, B. germanica, and A. alternata as a panel screening allergy for suspected allergic patients was suggested base on this study.
Non-electrostatic interactions associated with aggregate formation between polyallylamine and Escherichia coli
Authors: Nakatsuji Masatoshi , Sato Natsuki , Sakamoto Shiho , Watanabe Koji , Teruuchi Yoko , Takeuchi Minoru , Inui Takashi , Ishihara Hideki
Published: September 2023

Bacterial aggregation by mixing with polymers is applied as pretreatment to identify pathogens in patients with infectious diseases. However, the detailed interaction between polymers and bacteria has yet to be fully understood. Here, we investigate the interaction between polyallylamine and Escherichia coli by isothermal titration calorimetry. Aggregation was observed at pH 10 and the binding was driven by favorable enthalpic gain such as the electrostatic interaction. Neither aggregation nor the apparent heat of binding was observed at pH 4.0, despite the strong positive charge of polyallylamine. These results suggest that intermolecular repulsive forces of the abundant positive charge of polyallylamine cause an increased loss of conformational entropy by binding. Non-electrostatic interaction plays a critical role for aggregation.
Endoglin inhibitor TRC105 with or without bevacizumab for bevacizumab-refractory glioblastoma (ENDOT): a multicenter phase II trial
Authors: Ahluwalia Manmeet S. , Rogers Lisa R. , Chaudhary Rekha , Newton Herbert , Ozair Ahmad , Khosla Atulya A. , Nixon Andrew B. , Adams Bonne J. , Seon Ben K. , Peereboom David M. , Theuer Charles P.
Published: September 2023

Background

Glioblastoma (GBM), the most lethal primary brain tumor, has limited treatment options upon recurrence after chemoradiation and bevacizumab. TRC105 (carotuximab), a chimeric anti-endoglin (CD105) antibody, inhibits angiogenesis and potentiates activity of VEGF inhibitor bevacizumab in preclinical models. This study sought to assess safety, pharmacokinetics, and efficacy of TRC105 for bevacizumab-refractory GBM.

Methods

We conducted a pre-registered (NCT01564914), multicenter, open-label phase II clinical trial (ENDOT). We administered 10 mg/kg TRC105 monotherapy (first cohort) in adults with GBM and radiographic progression following radiation, temozolomide and bevacizumab therapy. Primary outcome was median time-to-progression (TTP), amended after first cohort’s enrollment to median overall survival (mOS). Secondary outcomes were objective response rate, safety and tolerability, and progression-free survival (PFS).

Results

6 patients were enrolled in TRC105 monotherapy cohort. Median TTP and PFS of 5 evaluable patients receiving monotherapy was 1.4 months, in whom plasma VEGF-A levels were elevated post-therapy. Lack of response led to protocol amendment, and second cohort’s addition of bevacizumab+TRC105 with primary endpoint of mOS. 16 patients were enrolled in bevacizumab+TRC105 cohort. mOS of 15 evaluable patients was 5.7 (95%CI: 4.2–9.8) months. All 22 patients had measurable disease at baseline. Median PFS of 14 evaluable patients receiving bevacizumab+TRC105 was 1.8 months (95%CI 1.2–2.1). Serum TRC105 was measurable above target concentration of 25 ug/mL in all evaluable patients. Study medications were well-tolerated in both cohorts. Combined administration did not potentiate known toxicities of either medication, with cerebral hemorrhage not observed.

Conclusions

Single-agent TRC105 lacks activity in bevacizumab-refractory GBM, possibly secondary to upregulated VEGF-A expression. Meaningful mOS in bevacizumab+TRC105 cohort warrants further trials to investigate efficacy of combination therapy.
A lateral flow immunoassay method for the rapid detection of acetochlor and alachlor in vegetable oil by sensitivity enhancement by using dimethyl-β-cyclodextrin
Authors: Li Zepeng , Wu Yuxiang , Li Zijing , Yu Binger , Mao Xinyi , Shi Guoqing
Published: September 2023

Acetochlor is an endocrine disruptor.
The glass transition in the high-density amorphous Zn/Co-ZIF-4
Authors: Du Zijuan , Qiao Ang , Zhou Hemin , Li Zhencai , Winters Wessel M. W. , Zhu Jiexin , He Guanjie , Parkin Ivan P. , Tao Haizheng , Yue Yuanzheng
Published: September 2023

Correlation between the configurational heat capacity (Cp,conf) and the molar ratio R (= Co/(Co + Zn)) of the ZIF-4 high-density amorphous phases (HDAs).
Surface-independent CO2 and CO reduction on two-dimensional kagome metal KV3Sb5
Authors: Chen Xin-Wei , Lin Zheng-Zhe , Li Meng-Rong
Published: September 2023

KV3Sb5 as a catalyst for CO2 and CO reduction.
Label-free optical biosensing: going beyond the limits
Authors: Kabashin Andrei V. , Kravets Vasyl G. , Grigorenko Alexander N.
Published: September 2023

We present newly-emerging approaches to unlock sensitivity barriers of current label-free optical biosensing transducers by employing novel structural architectures, artificial materials (metamaterials), and newly-observed optical phenomena.
Fluorescent and chromogenic organic probes to detect group 10 metal ions: design strategies and sensing applications
Authors: Goswami Nidhi , Naithani Sudhanshu , Mangalam Jimmy , Goswami Tapas , Dubey Ritesh , Kumar Pramod , Kumar Pankaj , Kumar Sushil
Published: September 2023

This study highlights various fluorescent and colorimetric organic sensors for detection of group 10 metal ions. Existing receptor design issues, challenges and promising development prospects are presented.
Synthesis of α-aminophosphorous derivatives using a deep eutectic solvent (DES) in a dual role
Authors: Mandal Susmita , Narvariya Rajrani , Sunar Shiva Lall , Paul Ishita , Jain Archana , Panda Tarun K.
Published: September 2023

Deep eutectic solvent (DES) as an efficient, cost-effective, reusable, and environmentally benign medium for the synthesis of α-aminophosphine oxide/phosphonates from the hydrophosphorylation of aldehydes, amines, and diphenylphosphine oxides/diethylphosphite is reported.
Bio-based captodative ligands for redox polymerization of Elium® thermoplastic composites under mild conditions
Authors: Giacoletto Nicolas , Le Dot Marie , Cherif Hizia , Morlet-Savary Fabrice , Graff Bernadette , Monnier Valérie , Gigmes Didier , Dumur Frédéric , Olleik Hamza , Maresca Marc , Gerard Pierre , Nechab Malek , Lalevée Jacques
Published: September 2023

Thermoplastic polymers obtained from Elium® combine desirable properties including recyclability/reusability. In this work new biobased redox initiating systems are proposed for Elium.
Unveiling the particle size effect and surface reactivity of Pt/C nanoparticles for ammonia electrooxidation using in situ infrared spectroscopy
Authors: Aligholizadeh K Niloofar , N Ashwini Reddy , Monyoncho Evans A. , Baranova Elena A.
Published: September 2023

In situ PM-IRRAS provides information about the reaction products of ammonia electrooxidation on the surface of Pt/C nanoparticles and in the bulk of electrolyte.
Atomic structures and interfacial engineering of ultrathin indium intercalated between graphene and a SiC substrate
Authors: Pham Van Dong , Dong Chengye , Robinson Joshua A.
Published: September 2023

The STM tip is used to visualize and to engineer the intercalated indium at the interface between graphene and SiC substrate with atomic precision.
Construction of benzoheterocycles by the reaction of α-arylglyoxylic acids and ortho-functionalized aniline under mild and minimal conditions
Authors: Gong Hang , Zhou Fangyuan , Cai Changqun
Published: September 2023

An environmentally friendly strategy was developed for the synthesis of benzoheterocycles. The reaction is simple and no other reagents are needed, except for reactants and solvents, and only water and carbon dioxide are generated as by-products.
On design of power sharing for VSC‐based islanded AC microgrids: An adaptive MIMO controller equipped with a predictor
Authors: Ahmadi Farahnaz , Batmani Yazdan , Bevrani Hassan
Published: September 2023

In an AC microgrid, the active/reactive power is usually shared among its distributed generators (DGs) based on the frequency‐active power () droop and the voltage‐reactive power () droop. By increasing the resistant/inductance ratio () of feeder lines; however, adverse effects of interactions between these two control loops are intensified. In this paper, an adaptive multi‐input multi‐output (MIMO) current control structure is proposed to tackle this problem in AC microgrids with arbitrary numbers of DGs in the primary control level. A deep analysis based on the relative gain array (RGA) matrix and the diagonal dominance concept is provided to systematically design MIMO controllers. The proposed technique is based on the Lyapunov's stability theory, and the asymptotic stability of the whole microgrid is guaranteed. For each DG, the suggested design procedure is started by defining a model reference in which the desired control objectives, including the settling time and the steady‐state error, are considered. Then, a feedback‐feedforward controller is established where its gains are adaptively tuned by some rules derived from a Lyapunov function. Moreover, a predictor is used to estimate the adverse effects of other DGs which are taken into account as external disturbances during the design process of the adaptive controller. By considering some realistic scenarios through time‐domain simulations in MATLAB/SIMULINK, it is shown that the proposed strategy can be successfully used to solve the power sharing problem in AC microgrids.
Combined model for 15N, 13C, and spin-state chemistry in molecular clouds
Authors: Sipilä O. , Colzi L. , Roueff E. , Caselli P. , Fontani F. , Wirström E.
Published: September 2023

We present a new gas-grain chemical model for the combined isotopic fractionation of carbon and nitrogen in molecular clouds. To this end, we have developed gas-phase and grain-surface chemical networks where the isotope chemistry of carbon and nitrogen is coupled with a time-dependent description of spin-state chemistry, which is important for nitrogen chemistry at low temperatures. We updated the rate coefficients of some isotopic exchange reactions considered previously in the literature, and here we present a set of new exchange reactions involving molecules substituted in 13C and 15N simultaneously. We applied the model to a series of zero-dimensional simulations representing a set of physical conditions across a prototypical prestellar core, exploring the deviations of the isotopic abundance ratios in the various molecules from the elemental isotopic ratios as a function of physical conditions and time. We find that the 12C/13C ratio can deviate from the elemental ratio to a high factor depending on the molecule, and that there are highly time-dependent variations in the ratios. The HCN/H13CN ratio, for example, can obtain values of less than ten depending on the simulation time. The 14N/15N ratios tend to remain close to the assumed elemental ratio within approximately 10%, with no clearly discernible trends for the various species as a function of the physical conditions. Abundance ratios between 13C-containing molecules and 13C+15N-containing molecules however show somewhat increased levels of fractionation as a result of the newly included exchange reactions, though they still remain within a few tens of percent of the elemental 14N/15N ratio. Our results imply the existence of gradients in isotopic abundance ratios across prestellar cores, suggesting that detailed simulations are required to interpret observations of isotopically substituted molecules correctly, especially given that the various isotopic forms of a given molecule do not necessarily trace the same gas layers.
Yield and quality of hemp seeds in the Republic of Bashkortostan
Authors: Bikbaeva Gulnur , Islamgulov Damir , Nhambongo Perola da Beauty
Published: September 2023

The article presents data on the results of studies of three hemp cultivars (Vera, Nadezhda, Omegadar-1), conducted in 2021-2022 in the environmental conditions of the southern forest-steppe zone of the Republic of Bashkortostan. Studies have shown the advantage of the Nadezhda cultivar in terms of morphometric parameters, weight of 1000 seeds, oil content, and yield.
Spatial variability of soil properties and its effect on meadow productivity
Authors: Sidorovaand Valeria , Yurkevich Maria
Published: September 2023

The spatial heterogeneity of the yield of perennial grasses was studied to identify soil factors that most affect the productivity of sown meadows in South Karelia. Soil variability was studied using various statistical and geostatistical methods. In the course of research, it was found that the best conditions for the growth of perennial grasses are created on soils with a carbon content of about 8% and a slightly acidic or close to neutral reaction environment. It is noted that the type of soil affects the organic carbon content and change in the yield of perennial grasses. In the diagnostic range of peat soils, as the transition from peat-mineral soils to peat soils the organic carbon content in the soil increases and the yield of grasses decreases. The acidity distribution is rather anthropogenic in nature.
Productivity of perennial herbage with the participation of Trifolium pratense L. on sod-podzolic soils of the Republic of Karelia
Authors: Evstratova Liubov , Nikolaeva Elena , Bakhmet Olga , Kuznetsova Larisa , Kondratiuk Elena
Published: September 2023

In the conditions of northern arable farming, the productivity and nutritional value of the dry mass of pure stand of Tr. pratense and three-component agrophytocenoses with the participation of meadow clover, as well as legume and cereal representatives (Galega orientalis Lam., Medicago varia Mart., Bromus inermis Leys., Phlum pratense L.) were studied. Against the background of spring fertilizing with N45P60K90 and two-time mowing, the yield of dry biomass of grass mixtures averaged 8.3-8.8 t/ha over four years compared to single-species sowing of meadow clover (7.8 t/ha). In terms of energy and protein productivity, the maximum indicators of one hectare were provided by agrophytocenoses of clover (7.54 thousand feed units, 84.8 GJ of exchange energy, 1.22 tons of crude protein) and clover-timothy with the addition of galega or alfalfa (up to 7.19 thousand, 87.7 GJ, and 1.09 tons, respectively). The highest nutritional value of the feed mass (up to 16.71% of crude protein and 138 g of digestible protein/feed units) was allocated to a single-species clover herbage.
Isolation and characterization of endophytic bacteria from Pennisetum purpureum Schumach
Authors: Nguyen Giang Van , Thi Giang Do , Thi Linh Vu , Pylnev V.V.
Published: September 2023

Pennisetum purpureum Schumach, commonly called elephant grass, found in tropical and subtropical climates is used as an energy crop as well as a forage grass. As part of an ongoing exploration of environmentally friendly agricultural approaches in Vietnam, which includes the utilization of endophytic species and endogenous bacteria in fertilizer synthesis, studies were conducted on elephant grass. Elephant grass specimens were gathered and examined to investigate the advantages of endogenous bacteria during elephant grass growth. Endogenous bacteria capable of generating IAA were identified from Pennisetum purpureum Schumach samples collected in the provinces of Hai Duong, Cao Bang, and Thai Nguyen. Five of these strains were chosen for their capacity to stimulate plant development and fight harmful bacteria. All selected strains were gram-negative and motile endophytic bacteria. After 72 hours in a medium with a pH of 7, 100 mg/l L-tryptophan, and 30°C on liquid NA media, the study identified five endogenous bacterial strains (HDR5, HDR9, TNT3, CBR1, and CBR2) that produced the maximum amounts of IAA. HDR5 and CBR2 strains demonstrated the ability to inhibit plant-pathogenic Xanthomonas strains. The investigation of HDR5’s 16S rRNA nucleotide sequence revealed that it is closely linked to the genus Enterobacter. The study suggests the use of endogenous bacteria in fertilizer synthesis as an effective and eco-friendly approach.
Pollination by bees in industrial crop production
Authors: Komlatskiy Grigoriy , Makarova Tatyana
Published: September 2023

In recent decades, beekeepers have faced challenges from the massive use of pesticides, climate change and the emergence of new diseases. Taking into account the fact that, as a result of the mass use of chemical plant protection products, the number of wild pollinating insects has significantly decreased, bees are the most effective performers of the pollinating function. In the last twenty years, Russian farmers have come to understand the role of bees in the industrial agrobiocenosis. It is economically advantageous to orient bees to efficient pollination, which requires a high concentration of colonies in a small area. The importance of bees in sunflower production goes beyond mere pollination. Studies have shown that plants visited by bees have a higher seed set, resulting in higher yields. In addition, the pollination process improves seed uniformity and quality. Since industrial crop production implies the placement of one monoculture on large areas, then, naturally, a large number of bees should be delivered to the sunflower array at once by the beginning of flowering. Only mobile beekeeping can cope with this task. Mobile beekeeping is a dynamic and adaptable approach to beekeeping, offering beekeepers increased flexibility, improved honey production.
Environmental problems of the Crimean coast territories
Authors: Vetrova Natalya M. , Mennanov Emran E. , Gaysarova Anastasia A. , Sadykova Gulchere E. , Shtofer Gennadii A.
Published: September 2023

The article describes the nature and degree of deformations of the coastal zone of the sea and coastal protection structures on the coast of the Kalamitsky Gulf of the Black Sea. In 2022, a team of authors made a visual survey of the coast on the territory of the Bakhchisarai district of the Republic of Crimea with a total length of 11.5 km. from the village of Beregovoe to the village of Uglovoye. As a result of the inspection, coast areas potentially dangerous for human health and life that are not suitable for normal use for recreational purposes were identified. Long-term field observations show that the creation of coastal protection in certain local areas, giving only a temporary positive effect for these areas, can have a very negative impact on neighboring and even remote areas; that is why the coastal protection issue should be solved at least on the scale of the coast of settlements, considering the conditions of a single system. When designing coastal protection measures, it is necessary to consider that separate protection of small areas of erodible coastal territories within a large area of the eroded coast is ineffective, since adjacent unprotected shores will recede under the action of a system of natural factors.
Full-Scale Electromagnetic Transient Modeling and Oscillation Suppression of a Wind Farm with SVG
Authors: Yang Jierui , Li Zhen , Zhang Zhaofeng , Wang Bin , Mou Xuepeng
Published: September 2023

With the gradual depletion of the earth’s resources and people’s attention to environmental issues, the access of renewable energy has been paid more and more attention by countries around the world. Wind is one of the pollution-free energy sources, and wind power generation is forming a boom in the world, because wind power generation does not need to use fuel, nor does it produce radiation or air pollution. The power of wind power generation is characterized by volatility and intermittence. When there is disturbance in the system, the wind farm is likely to oscillate and challenge the stability of the power grid. Therefore, the wind turbine generator must be connected to SVG system to realize dynamic reactive power compensation function, so as to ensure the stability of its operation in case of fault. In addition, the cause of wind turbine oscillation needs to be analyzed in detail to ensure its stability.
An evolving space framework for Oseen equations on a moving domain
Authors: Djurdjevac Ana , Gräser Carsten , Herbert Philip J.
Published: September 2023

This article considers non-stationary incompressible linear fluid equations in a moving domain. We demonstrate the existence and uniqueness of an appropriate weak formulation of the problem by making use of the theory of time-dependent Bochner spaces. It is not possible to directly apply established evolving Hilbert space theory due to the incompressibility constraint. After we have established the well-posedness, we derive and analyse a first order time discretisation of the system.
Optimal strategies for green supply chains with competition between green and traditional suppliers
Authors: Cong Jing , Pang Tao , Peng Hongjun
Published: September 2023

We consider a green supply chain that consists of a traditional supplier, a green supplier, and a manufacturer. We investigate the optimal strategies for the suppliers’ raw material prices, and the manufacturer’s production and green raw material ordering. In particular, we consider three price competition models: the traditional supplier-led model, the green supplier-led model, and the Nash game model. The results indicate that the more dominant the green supplier, the more likely the green material price will be higher than the traditional material price. In addition, the manufacturers’ product greenness level is the lowest under the green supplier-led model and the highest under the traditional supplier-led model. We also find that, as the manufacturer’s yield uncertainty increases, the prices of traditional and green raw materials both decrease with respect to the manufacturer’s product greenness level. Moreover, as customers’ green preference increases, the price of green raw materials increases, the price of traditional raw materials decreases, and the product greenness level increases.
Depopulation of the country and rural areas of Bulgaria and development of digital and precision agriculture in them
Authors: Slavova Gergana
Published: September 2023

During the last decades and years of transition, Bulgaria has seen extremely unfavorable and negative trends in its natural growth. It is entirely negative and reinforced by the rate of net migration and the widespread aging of the country's population leads to very unfavorable results for the population in the rural areas of the country. At the same time, the prerequisites for implementing precision and digital agriculture are being successfully developed in the world, Europe and Bulgaria.The purpose of the present study is to analyze the situation in the country from a demographic point of view, to determine whether the declining population in rural areas is not a prerequisite for the faster emergence of the process of digitization and precision agriculture in rural areas of Bulgaria.For the purposes of our research, scientific, statistical methods, as well as methods of induction, deduction, comparative analysis, GAP analysis were used, and its results can be successfully used and applied by all interested parties.
Political cycles of the Balkan region
Authors: Domentyan Valentin
Published: September 2023

The article analyzes the economic and financial relations between countries of the Balkan region, on the one hand, and the ones of the European Union, as well as, the United States of America, China and Russia, on the other hand. In contemporary information society, entirely, or partially forgotten symbols can be forerunners of changes in socio-economic structures. As Karl Gustav Jung said, “color and symbol rule the world because they are faster than thought”. Different countries and regions have their own symbols. Griffin, a flying lion, for instance, was a symbol of Tartaria, then it appeared to be a national symbol of Bulgarian and Romanian national currency. The symbol determines the cyclical nature of social and political processes and symbolizes political behavior that can be «unreasonable» in the opinion of the Italian sociologist and economist V. Pareto. Investigating the sense of political cycles and their symbols is of huge interest for modern researchers.
Control of a medical activities – main characteristics
Authors: Vasilev Presiyan
Published: September 2023

The main purpose of the of the paper is to analyze the infringement and the penalties imposed on inpatient and outpatient facilities for the period 2013-2022 and to highlight the problem areas in the inspected facilities. Data from the Reports on the activities of the Executive Agency “Medical Audit” (2013-2018) and the Executive Agency “Medical Supervision” (2019-2022) were used. On the basis of the data, an analysis of the administrative violation acts issued has been carried out, the most significant violations for the period under study have been highlighted, the choice of facilities subject to inspection, the most frequently inspected medical institutions, etc. have been examined. The main conclusion is that the Agency should focus more on transparency in the selection of the establishments to be inspected and continue in the direction of increasing its revenues and reducing the number of revoked penalty decrees.
Problems and opportunities related to the professional development of teachers of physical education and sport in the university
Authors: Peltekova Iren , Seisenbekov Yerlan , Iskakov Taiyrzham , Kokebayeva Rysgul , Baigutov Karim
Published: September 2023

Professional development can be achieved independently by reading books, scientific journals and other literature. But professional development with participation in international trainings, courses and seminars, the authors consider as the most valuable. This report reviews the problems and opportunities for professional development of physical education and sports professionals internationally. The aim is to present the opportunities for increasing the qualification of the sports pedagogical and academic staff, through participation in a qualification course with a foreign lecturer. Methods: Theoretical analysis of a course conducted to increase the qualification of the pedagogical staff. Results: The conducted international course was successful for the participating course participants from the Republic of Kazakhstan and for the Bulgarian lecturer. Similarities were found on the methodological side of the sports training of school teams and. Differences related to the management of the organization for participation in the competition process were found. Conclusion: Physical education and sports teachers work in isolation compared to teachers from other faculties. For them, international programs are unavailable or very limited. Legislation and university regulations need to find a way to work together more effectively to support university teachers who train physical education and sport teachers.
The Congenital Cardiology Cloud – optimizing long-term care
by connecting ambulatory and hospital medical attendance via
telemedicine
Authors: Rottermann Kathrin , Doll Ulrike , Pfenning Simon , Reichenbach Marc , Fey Dietmar , Dobler Alexander , Siauw Céline , Reif Fabian , Gnibl Julia , Cesnjevar Robert , Dittrich Sven
Published: September 2023

Background Patients with complex congenital heart disease frequently
undergo a life-long ambulatory therapy with the need for repeated hospital
interventions. To optimize this manifold interplay, we designed and implemented
a tele-medical service, the Congenital Cardiology Cloud (CCC). This study aims
to analyse the requirements for its implementation through the comprehensive
assessment of design, installation and impact on patient´s care.

Methods CCC’s development comprised the analysis of historically
raised admission and discharge management and the definition of technical and
organizational requirements. Elaboration of procedural flow charts, description
of data formats and technical processes as well as distribution of patient
structure formed part of this process.

Results Analysis of existing workflows uncovered a need for the rebuilding
of admission and discharge process and decision making for further treatment.
The CCC reduces conference-meetings in general and repetitive meetings up to
less than a third. Real-time dispatch of discharge documents guarantees an
instantaneous access to patient-related data. Comparative analyses show a more
complex patient group to be involved in tele-medical services.

Conclusions The CCC enables the sharing of complex clinical information by
overcoming sectoral barriers and improves mutual patient advice. Implementation
of a tele-medical network requires willingness, perseverance and professional
engagement. Future application analysis and possible introduction of refinancing
concepts will show its long-term feasibility.
New Route to Direct Synthesis of Symmetrical Ureas from Carboxylic Acids
Authors: Pujol M. Dolors , Jahani Daniel , Yassine Hasna , Khouili Mostafa
Published: September 2023

The first method for the direct conversion of carboxylic acids into ureas has been developed. The classical procedures described for the formation of ureas from carboxylic acids require two steps, preparation of the isocyanate followed by its aminolysis. In this work, aryl carboxylic and arylalkyl carboxylic acids have been transformed into symmetric ureas in a single step using DPPA or sodium azide as nitrogen source. The addition of water (method A) or the presence of solvent water (method B) was essential for the formation of symmetrical ureas from the corresponding carboxylic acids. The corresponding ureas have been obtained in good to excellent yields of 46 to 100%. This procedure is compatible with different substituents present in the starting carboxylic acid.
Combined Aerobic and Strength Training Improves Dynamic Stability and can Prevent against Static Stability Decline in Postmenopausal Women: A Randomized Clinical Trial
Authors: Marques Ana Claudia Fortaleza , Rossi Fabrício Eduardo , Neves Lucas Melo , Diniz Tiego Aparecido , Messias Iracimara de Anchieta , Barela José A. , Horak Fay B. , Júnior Ismael Forte Freitas
Published: September 2023

Objective To analyze the effect of combined training (CT) in postural control and gait parameters in postmenopausal women.

Methods A parallel-group, randomized, control study was conducted with 16 weeks of combined training (n = 16) versus a non-training control group (n = 12) in postmenopausal women (aged 59.3 ± 8.0). Pre and postintervention assessments included postural control (using an AMTI force platform – Advanced Mechanical Technology, Inc., Watertown, MA, USA) and gait impairments (using baropodometry). In addition, the upper limb strength and abdominal tests, as well as aerobic capacity, assessed functional indicators.

Results The CT intervention in postmenopausal women resulted in improved gait (stride length (p = 0.006); speed (p = 0.013); double support time (p = 0.045); and improved postural control (displacement area of postural sway in a normal base of support with eyes open (p = 0.006). Combined training increased functional indicators (abdominal - p = 0.031; aerobic capacity - p = 0.002).

Conclusion In conclusion, combined aerobic plus strength training effectively improved gait and balance control in older women. The postmenopausal women from the CT group walked faster and with bigger steps after the intervention than the control group. In addition, they presented decreased postural sway in standing and decreased the percentage of double support time while walking, which means improved static and dynamic balance control and functional indicators.
Not Just hydrocarbons: Japan’s multifaceted foreign policy approaches towards the GCC states
Authors: Matsuda Kazuto , Kozhanov Nikolay
Published: September 2023

This paper argues that in spite of the prevailing belief that the relations between Japan and the GCC states are primarily driven by the hydrocarbon trade, the Japanese authorities’ efforts to strengthen their ties with the GCC states are determined by a more complex set of factors. These include not only Japan’s energy security, but also its non-energy economic interests and geostrategic factors. The study thus demonstrates the salience of a multi-sectoral analytical approach, going beyond the traditional hydrocarbon trade, to grasp the full complexity of the increasingly multifaceted ties between Japan and the GCC states.
Spin-dependent charge transmission through chiral 2T3N self-assembled monolayer on Au
Authors: Stefani Andrea , Innocenti Massimo , Giurlani Walter , Calisi Nicola , Pedio Maddalena , Felici Roberto , Favaretto Laura , Melucci Manuela , Zanardi Chiara , Jones Andrew C. , Mishra Suryakant , Zema Nicola , Fontanesi Claudio
Published: September 2023

A gold surface is functionalized by chemisorption of the enantiopure N,N′-bis-[2,2′;5′,2″]tert-thiophene-5-yl methylcyclohexane-1,2-diamine (2T3N), a chiral oligothiophene derivative, via overnight incubation in a 2T3N ethanol solution. The Au|2T3N interface is characterized by x-ray photoelectron circular dichroism and comparing x-ray photoemission spectroscopy and electro-desorption results. Charge transmission at the Au|2T3N| solution interface is characterized by recording the cyclic voltammetry of the Fe(III)/Fe(II) reversible redox couple, finding a charge transfer rate constant, k°, variation from 1 × 10−1 to 3.3 × 10−2 cm s−1, when comparing the bare Au and the Au|2T3N interfaces, respectively. The “anomalous” high value of k° found for the chiral Au|2T3N interface can be rationalized on the basis of the chiral-induced spin selectivity effect, as further proved by magnetic–conductive atomic force microscopy measurements at room temperature. A spin polarization of about 30% is found.
Study on the mode transition of multi-hollow dielectric barrier discharge
Authors: Zhao Yajun , Shi Yaqin , Liu Shiyun , Huang Yuqing , Liu Zhiyan , Zhang Li , Jin Shanshan , Fang Zhi
Published: September 2023

The discharge mode of a multi-hollow dielectric barrier discharge (MHDBD) plays an important role in the treatment outcomes but has not been well studied. In this study, an MHDBD is fabricated to investigate the discharge characteristics and the mode transition from both electric and optical perspectives. Three discharge modes are recognized with the increase of the applied voltages: inner-wall discharge, mode A (12–13.3 kV); hole-inside discharge, mode B (13.4–14.3 kV); and hole-surface hybrid discharge, mode C (≥14.4 kV). It is found that the transferred charges and the produced reactive species increase slowly in mode A, then augment rapidly in mode B, and finally saturate in mode C. The micro-process of the mode transition shows that the discharging domain initiates at the edge of the hole (mode A), subsequently extends toward the center (mode B), and ultimately extends beyond the hole boundary (mode C). To further understand these transitions, finite element simulations and an equivalent circuit model of MHDBD are conducted, which reveal enhanced discharge strength and discharge area as the system progresses from mode A to mode B and C. The speculative mechanism of a mode transition involves the variation of the electric field distribution and the resulting acceleration of the electrons, and the following collision responses. Additionally, the effect of pulse frequency and hole diameter of the MHDBD on the mode transition conditions is also investigated, and the results show that higher frequencies are easier to prone mode transition, while large holes have fewer discharge modes.
Modeling structure–properties relations in compositionally disordered relaxor dielectrics at the nanoscale
Authors: Gurung Ashok , Mangeri John , Hagerstrom Aaron M. , Orloff Nathan D. , Alpay S. Pamir , Nakhmanson Serge
Published: September 2023

The solid solution Ba1−xSrxTiO3 (BSTO) displays dielectric response that is highly tunable, while also exhibiting low losses in a broad frequency regime, including the microwave band. Therefore, there is a need for a better understanding of the influence of the BSTO microstructure on its relaxor properties and performance in a variety of technological applications. Since the local polarization in BSTO is strongly dependent on composition, so is its response to an applied AC field. In this work, we have adopted a phase field method to study the frequency-dependent dielectric response of this system while accounting for the local fluctuations in the solid-solution composition. By utilizing a thermodynamic potential that includes spatial dependence on the averaged Sr content, we connected relaxor-like features in the dielectric dispersion to local spatial inhomogeneities, such as average size of Sr- or Ba-rich regions, across a wide range of temperatures. These results show that the adopted simple coarse-grained approach to the relaxor problem is sensitive enough to reveal correlations between the frequency and temperature dependence of the dielectric response and modulations in the material morphology and microstructure.