bluuebunny/crossref_metadata_2025 huggingface dataset:
Isolation of Antimicrobial Peptides (AMPs) From Different Sources: A Review
Authors: Islam Md Monirul , Zaman Sabbir Uz , Asif Fahim , Hasan Arnab Md Kamrul , Rahman Md Mostafizur , Hasan Moynul
Published: January 2023

Antimicrobial peptides (AMPs) are small peptide molecules produced by a wide range of species, from bacteria to higher vertebrates, as a part of the innate immune system. These naturally produced peptides fight against intrusive microbes like viruses, bacteria, and fungi. AMPs are produced in various body parts by different organisms, such as skin secretion of amphibians; leaf, stem, fruits, or whole parts of plants; glandular secretion of mammals; the venom of reptiles and arthropods, etc. Due to this source variation, there is no universal method for the isolation, i.e., extraction and purification of the AMPs. Therefore, several techniques have been established to extract and purify these natural peptides from various sources. Generally, solid-phase extraction and chemical extraction techniques are the most common methods used for the extraction of AMPs. For purification and identification purposes, chromatography, gel electrophoresis, filtration, Edman degradation, circular dichroism, mass spectrometry, etc. are mainly adopted. In this review, we provide a brief discussion on the isolation process of AMPs based on their sources. This study would be helpful in isolating newer AMPs that could be used as potential antimicrobial agents.
Bangladesh Pharmaceutical Journal 26(1): 99-111, 2023 (January)
Sparse regression with clustered predictors
Authors: Kenny Aiden , Solomon Danielle , Patwary Mohammad S A , Das Kumer P
Published: February 2023

Gene expression data can be challenging to analyze due to its high-dimensional nature. Regularization techniques are useful in reducing the number of predictors and highlighting the signiﬁcant genes, in this case, genes that may indicate the presence of cancer. This study aims to see if grouping the genes before applying the regularization techniques is beneﬁcial in reducing the prediction error of classiﬁcation. We investigate the potential effectiveness of using clustering algorithms to generate a grouping structure for high-dimensional data sets. Using various regularization techniques, we seek to determine if the generated groups are truly relevant to the response and if the accuracy and interpretability of the models can be improved. We apply the clustered group structure to two real-world data sets. We also employ simulation studies to assess the performance of different regularization methods for both clustering and no-clustering methods.

Journal of Statistical Research 2022, Vol. 56, No. 1, pp. 37-53
Modelo de innovación sustentable para el desarrollo socio territorial en zonas rurales del Ecuador
Authors:   Universidad del Azuay, Sánchez Claudio , Prado-Jiménez Julio César ,   Universidad del Azuay
Published: January 2023

El presente proyecto se enfoca a la aplicación y validación de la metodología, la innovación social y sustentabilidad en zonas rurales en el Ecuador. Para este proceso se realizó el primer caso de aplicación en el país en la planta de lácteos de la comunidad de Las Nieves, ubicada en el cantón Pucará. Para su desarrollo realizamos un convenio marco de cooperación entre el Gobierno Autónomo Descentralizado Municipal de Pucará y la Universidad del Azuay, en el mismo participan tres escuelas de la universidad: La Escuela de Ingeniería en Alimentos bajo el laboratorio de Tecnología Biomolecular, el cual lidera el proyecto por su investigación y experimentación científica de innovación láctea, junto a esta Escuela también se vinculan la Escuela de Diseño Gráfico para el desarrollo de marca corporativa y la Escuela de Marketing para el desarrollo de estrategias de promoción y venta de los productos lácteos. 92 páginas ISBN: 978-9942-778-03-1
Las palabras y la cultura (II)
Authors:   Universidad del Azuay, Encalada-Vásquez Oswaldo
Published: January 2023

Las palabras son los símbolos más importantes creados por los seres humanos. Con ellas ensamblamos nuestras ideas y razones y con ellas expresamos nuestros sentimientos más recónditos. La lengua es, de este modo, la creación cultural clave que sustenta lo que somos y lo que hacemos. La cultura es sobre todo la capacidad de generar símbolos, códigos de comportamiento, maneras de ser: el software de la mente, como dijera Clifford Geertz. Y las palabras, a su vez, recrean la cultura, le dan color, olor y sabor: su sazón de ser. Deleitándose con gana ubérrima en la enjundia de los verbos y los nombres, Oswaldo Encalada prosigue su intento de formular una historia social de las palabras, con una narrativa que agrada y provoca, que elucida y revela, que motiva y convoca. La Universidad del Azuay se honra nuevamente, al publicar con el sello de su Casa Editora, esta obra que –al mismo tiempo- fructifica y sigue en ciernes, que es realización y proyecto inacabado. Porque esperamos degustar del siguiente texto, del que está por venir y que nos hace agua la boca. Este es un libro que va creando escuela, en el sentido original del término: es una obra para pasarla sabroso.178 páginas ISBN: 978-9942-778-00-0 e-ISBN: 978-9942-778-01-7
Las palabras y la cultura (I)
Authors:   Universidad del Azuay, Encalada-Vásquez Oswaldo
Published: January 2023

El objetivo de este libro es mostrar las profundas interrelaciones de las palabras con la cultura, con la historia. Para ello debemos acudir necesariamente a los orígenes y a la etimología. De estas fuentes mana el sentido, se diversifica, se especializa. La verdad etimológica nos permite entender mejor el sentido de lo que decimos. Es el caso, por ejemplo, de la conocida frase del filósofo español José Ortega y Gasset (v. 84. Yo soy yo y mi circunstancia). La circunstancia, en términos etimológicos es lo que está alrededor de uno. ¡Qué clara y precisa constatación del influjo que el medio ejerce sobre la conformación y construcción del individuo! La investigación etimológica permite encontrar –redescubrir- desconcertantes relaciones entre las palabras, como es el caso de los términos asaltar e insultar (v. 43. No solo que asaltan sino que, además, insultan). O nos permite conocer exactamente el aspecto negativo y el origen del libertinaje (v. 15. ¿Por qué es malo el libertinaje?) Y así como estos hay muchos casos más. Por la forma como ha sido concebido este libro aspiramos a que se lo mire y se lo juzgue como una historia social de las palabras, a través de 121 breves ensayos. 168 páginas ISBN: 978-9978-325-47-6 e-ISBN: 978-9978-325-52-0
Sistem Keamanan Pintu Menggunakan Sensor Sidik Jari Berbasis Mikrokontroller Arduino UNO R3
Authors: Dita Putu Eka Sumara , Fahrezi Ahmad Al , Prasetyawan Purwono , Amarudin Amarudin
Published: February 2023

Penelitian ini bertujuan merancang dan mengimplementasikan sebuah rangkaian yang berfungsi untuk keamanan dan mengikuti teknologi yang dipasang pada keamanan pintu dan mengendalikan yang ada pada pintu seperti sensor sidik jari berbasis Arduino yang untuk membuka dan menutup pintu. Dan membahas mengenai Module Fingerprint yang digunakan untuk mendeteksi sebuah frekuensi yang akan menjadi output dan input bagi Mikrokontroller Arduino. Untuk menggontrol Mikrokontroller Arduino digunakan bahasa pemerograman C dan arduino dengan menggunakan software Arduino. Module Fingerprint menerima sinyal frekuensi dan diinputkan pada Solenoid door lock, dan diolah oleh Microkontroller Arduino lalu dioutputkan melalui relay sebagai penghubung arus jalur pada Solenoid Door Lock dan Motor Servo.
SISTEM PENGELOLAAN KEBERSIHAN BERBASIS MIKROKONTROLER ARDUINO PADA PETERNAKAN UNGGAS
Authors: Seftiana Meiwidia , Najeri Ari , Anggono Harry , Priandika Adhie Thyo
Published: February 2023

Penelitian ini akan mengembangkan alat pembersih kotoran unggas otomatis berbasis mikrokontroler. Membersihkan kandang unggas tentu menjadi masalah dalam beternak unggas. Membuat alat ini adalah cara membersihkan kandang unggas dengan desain yang sesuai dengan kandang unggas. Perangkat alat ini menggunakan mikrokontroler Arduino Uno sebagai pengontrol sistem alat dan didukung oleh motor DC yang sudah dilengkapi dengan gearbox, sehingga memiliki torsi untuk memindahkan kotoran unggas yang dapat digunakan dalam van Compeyor sebagai media bergerak. Alat ini menggunakan modul RTC untuk mengotomatiskan rentang waktu dan tombol sebagai opsi manual. Cara kerja alat ini berkaitan dengan modul RTC sebagai media untuk menentukan tampilan waktu yang ditentukan oleh sistem Arduino. Tombol manual untuk eksekusi manual dari alat. Dari hasil pengujian yang dilakukan, dapat disimpulkan bahwa alat yang diproduksi adalah alat pembersih kotoran unggas dengan kontrol Arduino dan RTC untuk perencanaan pembuangan terkait waktu.
Enhancing Environmental Literacy Using EMKONTAN Learning for Biology Teacher Candidates
Authors: Nurwidodo N. , Wahyuni Sri , Hindun Iin
Published: February 2023

This study aims to analyze the effectiveness of the EMKONTAN learning model in improving environmental literacy for prospective biology teacher students. EMKONTAN is a student-centered learning model (students active learning), oriented to creative learning, problem-based learning, collaborative learning and provides opportunities for students to improve environmental literacy. This research was conducted in the event semester of the 2020/2021 academic year at IKIP Budi Utomo Malang (IBU) and FTTE Universitas Muhammadiyah Malang (UMM), involving 150 second semester students through total sampling. Data obtained through observation, questionnaires and tests. The research used a pretest-posttest non-equivalent control group design. The experiment was conducted from March to July 2021. Data collection in this study was carried out using Google Form, Google Classroom, Google Meet, and WhatsApp. Data analysis using SPSS software version 23. The ANCOVA analysis results showed that EMKONTAN, PBL affected students' creativity, collaboration skill and environmental literacy on biology teachers candidate students with a value of p<0.005. The LSD result was significantly different in improving students' environmental literacy. The EMKONTAN class gained the highest posttest score. Therefore, EMKONTAN could be applicable to improve environmental literacy outcomes in environmental learning.
Prototipo de dispositivo de desinfección por efecto corona a base de electrónicos desechados
Authors: Rodríguez Thomas , Hou Kallam , Chávez Melany , Marín Nacari
Published: January 2023

La desinfección y sanitización es un tema que ha evolucionado en importancia durante la crisis sanitaria que ha afectado a la población mundial, provocando la multiplicación de esfuerzos para mejorar los métodos conocidos de desinfección. Para este proyecto se propone el desarrollo de un prototipo de dispositivo de desinfección con funcionamiento a base de plasma y ozono, construido a partir de componentes electrónicos desechados. Se procede a diseñar y construir el dispositivo de desinfección para realizarle pruebas de funcionamiento. Se sabe que el modelo mostrado en este artículo presenta fallas que deben ser mejoradas en versiones posteriores. Finalmente, se dan algunas recomendaciones sobre posibles mejoras en el prototipo que garanticen su funcionamiento correcto.
Propiedades nutracéuticas de Pleurotus spp.: Aplicaciones en la ovinocultura en la Región de Amecameca
Authors: García Rubio Virginia Guadalupe , Aguilar Marcelino Liliana , Andrade Gallegos René Humberto , Sánchez Vázquez José Ernesto , Ojeda Carrasco Juan José
Published: January 2023

Para satisfacer la creciente demanda de alimentos, es necesario impulsar estrategias encaminadas al fortalecimiento de las actividades agrícolas y pecuarias que se desarrollan en los territorios locales, como una vía factible para optimizar los recursos disponibles y generar impactos positivos tanto en lo económico, social como ambiental. Contribuir con la generación de conocimiento sobre los procesos productivos regionales, sus características, condiciones y áreas de oportunidad, permite conocer la problemática que enfrentan, como base para proponer alternativas asequibles que generen una sinergia entre procesos. Esta investigación se realizó en cuatro municipios de la Región de Amecameca, Estado de México (México), en los cuales además de localizar y caracterizar las unidades de producción de hongos comestibles Pleurotus spp. se recuperan los usos que se le da a los hongos y sustratos poscosecha, con el objeto de promover un mejor aprovechamiento por sus propiedades nutracéuticas en la alimentación humana y de los ovinos, respectivamente. En el trabajo de campo, se generó información cualitativa y cuantitativa de las UP mediante la aplicación de entrevistas y observación participante; de igual forma, se realizó la colecta de ejemplares que fueron identificados taxonómicamente y cultivados in vitro en laboratorio, para la obtención del micelio empleado para la genotipificación de las especies. La información generada se analiza de forma integral para destacar las áreas de oportunidad y las potencialidades que ofrecen estos recursos locales para la seguridad alimentaria en la región.
Diseño de un reactor químico de polimerización para la producción de ácido poliláctico
Authors: Loor Chavez Aleida America
Published: January 2023

Debido a los problemas medioambientales ocasionados por la producción de plásticos convencionales, se ha optado por el desarrollo de alternativas como la producción de polímeros de fuentes renovables, los cuales se pueden obtener de materias primas ricas en almidón. La síntesis de estos materiales requiere el establecimiento de condiciones de trabajo, además del dimensionamiento de equipos para alcanzar una máxima eficiencia. En este sentido, el presente trabajo tiene como objetivo diseñar un reactor químico para la producción de ácido poliláctico, estableciendo las principales características del producto y los datos más relevantes para el diseño. La polimerización se realizó por el método de apertura de anillo (ROP), con la síntesis de lactida en presencia de metanol y cloruro de estaño (II) como catalizador. Entre los resultados obtenidos se presenta el volumen del reactor en función de la velocidad de polimerización que es de 3.74 L, la densidad del producto fue de 1,171.21 kg/m3, la velocidad de reacción fue de 0.0036 mol/L*h y una potencia requerida de 0.14 kW, lo que indica que no es necesaria la implementación de un motor trifásico. El dimensionamiento de equipos es un aspecto que considera el diseño de plantas, por ello se debe considerar la disponibilidad de materias primas, condiciones operaciones y rendimientos del proceso, para un adecuado cálculo de reactores a emplear en procesos de polimerización.
Diseño y validación de un instrumento de investigación para proponer metodología de gestión de proyectos
Authors: Bazurto Roldán José Antonio , Alvarez Roberto Marcelo , Miro Vera Yini Airet , Brie Santiago
Published: January 2023

Las metodologías para el diseño y gestión de proyectos son cada vez más necesarias y aplicadas con mayor frecuencia en el sector público en Latinoamérica. Continuamente hay actualizaciones y nuevos enfoques en la gestión de proyectos de inversión, por lo que el estudio en las metodologías es relevante a nivel investigativo. El diseño de instrumentos de investigación confiables que sirvan para promover el uso de estas metodologías es importante para asegurar la calidad en el proceso. Por lo que el objetivo de este estudio es diseñar y validar un instrumento que permita recolectar y gestionar sistemáticamente información de proyectos para obtener las variables que permitan definir la metodología apropiada para cada organización, en este estudio se ha tomado como referencia en el sector público la Subsecretaría de Recursos Pesqueros (SRP) en Ecuador. El instrumento, toma como referencia la Norma International Organization for Standardization (ISO) 10006, la Guía de Fundamentos de Gestión de Proyectos, por su nombre en inglés Project Management Body of Knowledge (PMBOK), las Metodologías de Diseño de Proyectos de la Universidad Politécnica de Cataluña (MDP-UPC) y de la Secretaría Nacional de Planificación y Desarrollo (SENPLADES) del Ecuador. Como resultado, se desarrolló una encuesta, a cuyo instrumento se realizó la validación interna y externa en función de parámetros de confiabilidad, contenido y constructo. Se realizó análisis factorial para determinar variables utilizando sistema estadístico SPSS. Finalmente, se cuenta con la validación del instrumento diseñado asegurando que es confiable y cumple con los parámetros necesarios para obtener variables que definan la metodología para elaboración de proyectos en el sector público de Ecuador.
Regionalismo político-ideológico en el continente americano: los diferentes procesos y estructuras de regionalización política y sus características
Authors: Guerra B Jackeline M. , Nouvet Victoria , Gómez U. Arley , Rodríguez-Rodríguez Roberto
Published: January 2023

El presente artículo pretende investigar y estudiar el regionalismo político-ideológico en el continente americano enfocado en los distintos procesos y estructuras que caracterizan la regionalización política, con el objetivo de conocer los patrones ideológicos que alimentan la evolución de las tendencias políticas que marcan el proceso de integración. La investigación se basó en una metodología de tipo descriptiva y cualitativa empleando un método documental. El regionalismo político-ideológico americano de las últimas tres décadas ha abierto un nuevo camino en la inserción de la región en el sistema internacional, no obstante, presenta profundas divisiones que responden a claras facciones políticas que siguen patrones ideológicos ligados a los intereses de los gobiernos de turno de los Estados. En el caso de la República de Panamá, a pesar de que ha ayudado a la construcción del regionalismo político e ideológico de la región, en las últimas décadas se ha apegado estratégicamente a prácticas multilateralistas para lograr propósitos soberanos. Se concluye que la construcción del regionalismo político-ideológico se caracteriza por esbozar tendencias dinámicas y claramente definidas, aunque la integración en la misma tiende a ser asimétrica y distante de construir bloques sólidamente cohesionados. Finalmente, la cooperación y el multilateralismo surgen como aliados para la búsqueda de consensos regionales y despolitizar la integración, utilizando la política como la base para lograr objetivos y las ideologías como el enlace para llegar a acuerdos.
APPLICATION OF THE K-NEAREST NEIGHBOR (KNN) ALGORITHM IN SENTIMENT ANALYSIS OF THE OVO E-WALLET APPLICATION
Authors: Masturoh Siti , Pratiwi Risca Lusiana , Saelan M Rangga Ramadhan , Radiyah Ummu
Published: February 2023

Abstract— The OVO application can be downloaded on the Android platform via Google Play, Google play has a review feature on the application product to be downloaded, so that the review can be viewed or accessed by anyone, With these reviews, potential users of the application will see how important it is to consider using an application, problems regarding reviews or sentiment analysis of applications processed using text mining. The purpose of this study is to provide information to prospective OVO application users before using the application which can be seen from the results of giving reviews based on rating or stars (*) in the OVO application review column on Google Play and the authors categorize them into 3 classes, the first class ( 1 to 5 stars, second class (1 and 5 stars) third class by providing labeling grouping (1&2 stars are negative labels, 3 stars are neutral labels and 4&5 stars are positive labels) testing using the k-nearest neighbor method by finding the value of k from the k value of 1-10 to get the highest accuracy value, in order to obtain the highest accuracy value of 84.86% in the 2nd class test and giving a value of k 1 which means that the 1st and 5th star tests get positive values so that they can give a good impression to prospective application users OVO
SENTIMENT ANALYSIS OF ONLINE GOJEK TRANSPORTATION SERVICES ON TWITTER USING THE NAÏVE BAYES METHOD
Authors: Fahmi Muhammad , Puspita Ari , Yuningsih Yuyun
Published: February 2023

Abstract— Social media is the most accessed internet content by internet users in Indonesia. This is not surprising, given the many benefits that social media provides, one of which is the benefit of self-expression. Self-expression can include many things, including emotional openness, which is the openness of a person in conveying the emotions he is feeling. Along with the development of social media, emotional disclosure is ubiquitous in social media, one of which is social media Twitter. With the development of information technology, means of transportation are also developing with the existence of online transportation services. Currently, the use of online transportation services has become a necessity, so it is necessary to conduct a sentiment analysis on online transportation services to find out how the public responds to these online transportation services. The purpose of this study is to analyze community responses by analyzing data in the form of tweets and then classifying them into positive, negative, and neutral classes using the Naïve Bayes method because the error rate obtained is lower when the dataset is large, besides that the accuracy of Naive Bayes and the speed is higher. high when applied to a larger dataset. The results of this study indicate that the neutral sentiment level of public tweets is greater than the level of positive sentiment and negative sentiment with an accuracy of 25.00%.
FOREIGN INSTITUTIONAL OWNERSHIP AND CASH HOLDINGS IN INDONESIA CAPITAL MARKET
Authors:   Universitas Andalas Indonesia, Chandra Ramadhani , Rahman Annisaa ,   Universitas Andalas Indonesia
Published: January 2023

Research Purpose. The purpose of research is analyzing the effect of foreign institutional ownership on cash holding, based on precautionary motive. Research Method. This research uses quantitative methods, with single independent variables (foreign institutional ownership). Cash holding (dependent variable) measured using the formula logaritma cash and cash equivalents. Population used in the study is all non-financial companies listed on the Indonesia Stock Exchange 2017-2019. The purposive sampling method used and obtained 1170 firm-year samples. Secondary data sourced from annual reports and financial statement and data analyzed using multiple linear regression analysis with variabel control (leverage). Research Result and Findings. The results of this study indicate that the foreign institutional ownership has positive effect on cash holding.
PENGARUH PENGGUNAAN APLIKASI QUIZIZZ TERHADAP HASIL BELAJAR SISWA KELAS IV SEKOLAH DASAR
Authors: Maharani Fitri , Erlisnawati  , Alpusari Mahmud
Published: January 2023

Tujuan penelitian ini adalah untuk melihat efektivitas penggunaan aplikasi Quizizz terhadap hasil belajar siswa kelas IV Sekolah Dasar. Pada penelitian ini jenis pendekatan yang digunakan adalah kuantitatif dengan metode eksperimen. Bentuk penelitian ini Pre Experimental dengan desain penelitian One-Group-Pretest-Posttest Design. Subjek penelitian ini adalah siswa kelas IV SD IT Humairoh 2 Pekanbaru sebagai kelas eksperimen. Penelitian ini menggunakan aplikasi Quizizz sebagai alat evaluasi atau penilaian setiap akhir pembelajaran. Hasil penelitian menunjukkan pada data pretest memperoleh rata-rata 50.00 dan hasil posttest adalah 82.80. Perhitungan uji hipotesis memperoleh hasil sig (2-tailed) 0.000 < 0.05 yang menunjukkan bahwa penggunaan aplikasi Quizizz dapat meningkatkan hasil belajar IPS siswa kelas IV sekolah dasar. Berdasarkan hasil uji N-Gain didapatkan peningkatan hasil belajar kelas eksperimen sebesar 64.0% yang termasuk pada kategori efektif.  Kemudian untuk melihat seberapa besar pengaruh yang diberikan dihitung dengan uji Koefisien Determinasi (R-Square) diperoleh hasil sebesar 0.524%. Sehingga disimpulkan bahwa penggunaan aplikasi Quizizz efektif dalam meningkatkan hasil belajar siswa kelas IV Sekolah Dasar.
PENGEMBANGAN LEMBAR KERJA SISWA (LKS) BERBASIS CERITA BERGAMBAR PADA MATA PELAJARAN IPS KELAS V SDN 007 KAMPUNG BARU GUNUNG TOAR
Authors: Rahayu Riska , Erlisnawati
Published: January 2023

Tujuan dari penelitian ini adalah untuk menghasilkan bahan ajar LKS berbasis cerita bergambar materi kegiatan ekonomi masyarakat Indonesia yang memenuhi kriteria valid dan sangat layak. Penelitian yang dilakukan adalah jenis penelitian pengembangan menggunakan metode ADDIE dengan lima tahap pengembangan, yaitu: analisis (analysis), desain (design), pengembangan (development), implementasi (implementation), dan evaluasi (evaluation). Jenis diambil dari kelayakan dan kualitas media. Instrumen yang digunakan adalah angket validasi untuk mengukur kelayakan media dan respon siswa untuk mengukur kualitas media. Subjek dalam penelitian berjumlah 12 siswa kelas V SD. Hasil penelitian menunjukkan bahwa LKS berbasis cerita bergambar materi kegiatan ekonomi mayarakat Indonesia memenuhi kriteria valid dan sangat layak dengan persentase validator ahli materi sebesar 86,45%, ahli media sebesar 90,13%, dan praktisi sebesar 91,80%, persentase uji coba satu-satu adalah 84,16%, dan uji coba terbatas mendapatkan skor persentase 87,29. Dapat disimpulkan bahwa LKS berbasis cerita bergambar sudah layak digunakan.
PENGEMBANGAN MEDIA PEMBELAJARAN E-MODUL UNTUK MATA KULIAH BARTENDING
Authors: Suryani Sevi , Mashabi Nurlaila Abdullah , Mulyati
Published: January 2023

Penelitian Pengembangan Media Pembelajaran E-Modul untuk Mata Kuliah Bartending ini bertujuan untuk mengembangkan media interaktif berupa e-Modul untuk mata kuliah Bartending dan menguji kelayakan media yang telah dikembangkan pada program studi Pendidikan Kesejahteraan Keluarga khususnya konsentrasi Akomodasi Perhotelan. Metode yang digunakan dalam penelitian ini adalah metode ADDIE (Analyze, Design, Development, Implementation, dan Evaluation) dan menghasilkan produk media pembelajaran berupa e-modul yang mencakup materi teori, yaitu Konsep Bar, Klasifikasi dan Struktur Organisasi Bar, Bar Layout, dan Beverages. Kelayakan e-modul ini dilihat berdasarkan hasil uji validitas dan uji praktikalitas oleh subjek penelitian, yakni Ahli Materi, Ahli Media, serta responden yang merupakan mahasiswa Program Studi Pendidikan Kesejahteraan Keluarga Konsentrasi Akomodasi Perhotelan. Berdasarkan hasil penelitian, hasil uji validitas oleh Ahli Materi sebesar 92,9%, hasil uji validitas oleh Ahli Media sebesar 95% , hasil uji perorangan oleh mahasiswa sebsar 95,6%, dan hasil uji coba kelompok kecil oleh mahasiswa sebesar 94,1% yang disimpulkan bahwa media pembelajaran E-Modul untuk Mata Kuliah Bartending ini dinyatakan Sangat Layak dan Sangat Praktis.
Climate Change Health Emergency: The Role of Healthcare Professionals
Authors: Colvin Katherine
Published: January 2023

THE IMPACT of climate change is clear, urgent, and formidable, with the effects of climate change on health an immediate threat to patients and populations both now and in the future. The Royal Society of Medicine (RSM) shared a series of 10 expert-led presentations on the ‘Health Emergency of Climate Change’ in 2021, with the closing presentation focusing on the role of healthcare professionals in addressing the health impacts of climate change. Linda Luxon, RSM Council Trustee, hosted a discussion between Cheryl Holder, President of the Florida State Medical Association and Co-chair of the Florida Clinicians for Climate Action, USA; David Pencheon, Founding Director of the National Health Service (NHS) Sustainable Development Unit, UK; and Rita Issa, Clinical Research Fellow in Climate Change, Migration and Health at University College London, UK, and Co-founder of Doctors for Extinction Rebellion. Their discussion highlighted the scope of the issue facing healthcare professionals, identifying strategies that can allow clinicians to be advocates for the health of their patients as well as have an impact on wider policy and systems-level changes to address this health emergency.
Rosacea: The Patient Experience is Now ‘CLEAR’
Authors: Scott Brigitte
Published: January 2023

These ‘Meet The Expert’ sessions took place during the 28th Congress of the European Academy of Dermatology and Venereology (EADV). Prof Schaller introduced the many faces of rosacea and explained that this disease can present as a single phenotype, but more often presents as a combination of phenotypes, including transient erythema (flushing), persistent erythema, telangiectasia, inflammatory papules/pustules, phymas, or ocular abnormalities, and is not easy to diagnose or classify. The most commonly used classification system for rosacea is that of the National Rosacea Society (NRS); however, this classification does not reflect the everyday clinical situation. Patients with rosacea have a high burden of disease. Correct diagnosis and effective treatment, which should continue until the patient is ‘clear’, is required to lower the burden of rosacea. Prof Schaller emphasised that achieving ‘clear’ is clinically meaningful for the patient, with benefits including improved quality of life, longer time to relapse, reduced social and productivity burden, and increased overall happiness. Prof Schaller introduced ROSCO, the Rosacea Consensus panel, which defined the most important clinical phenotypes of rosacea to form the basis of diagnosis and effective treatment of the disease. The ROSCO treatment algorithm enables healthcare providers to make a clear diagnosis and aim treatment towards, and achieve, a ‘clear’ goal. No two rosacea patients are the same, so treatment needs to be individualised, as shown in the three presented case studies. Prof Schaller concluded that the ROSCO classification, treatment algorithm, and recommendations have simplified the task of effective diagnosis and treatment of rosacea by addressing the multiple features and aiming for ‘clear’. A phenotype-based approach could improve patient outcomes to ‘clear’, with ‘clear’ versus ‘almost clear’ being the primary objective because of the extended relapse time and the patient quality of life benefits.
New Trends in Cellulitis
Authors: Atzori Laura , Manunza Francesca , Pau Monica
Published: January 2023

Cellulitis is a severe infection of the soft tissues, with a variable aetiology from Gram-positive to Gram-negative bacteria and deep fungal infections, whose early recognition is mandatory to avoid potentially life threatening complications. Some pathogens might cause very similar clinical entities, and cellulitis differentiation at presentation towards abscess, necrotising fasciitis, and gangrene, requires expertise. Many mimics are also to be excluded, conditioning the treatment and patient’s prognosis. The dermatologist is in a lead position to avoid misdiagnosis, to evaluate the type of assessment, and address initial treatment. Besides, skin and soft tissue infections are a common reason for emergency room visits and hospital admission, lacking precise clinical definition and managed with empirical antibiotic treatments. History, physical examination and laboratory data can help characterise the severity of the disease, and the probability of complications development, mainly necrotising fasciitis. Several admittance scores have been proposed to address the emergency decisions, and guidelines for treatment proposed. The present review will focus on clinical challenges and actual open questions on cellulitis management.
Diffusion Tensor Imaging Of the Brain in Type 1 Diabetes
Authors: Antenor-Dorsey Jo Ann V. , Shimony Joshua S. , Hershey Tamara
Published: January 2023

Individuals with Type 1 diabetes mellitus (T1DM) are required to carefully manage their insulin dosing, dietary intake, and activity levels in order to maintain optimal blood sugar levels. Over time, exposure to hyperglycaemia is known to cause significant damage to the peripheral nervous system, but its impact on the central nervous system has been less well studied. Researchers have begun to explore the cumulative impact of commonly experienced blood glucose fluctuations on brain structure and function in patient populations. To date, these studies have typically used magnetic resonance imaging to measure regional grey and white matter volumes across the brain. However, newer methods, such as diffusion tensor imaging (DTI) can measure the microstructural properties of white matter, which can be more sensitive to neurological effects than standard volumetric measures. Studies are beginning to use DTI to understand the impact of T1DM on white matter structure in the human brain. This work, its implications, future directions, and important caveats, are the focus of this review.
Acute Pancreatitis – Beyond Gallstones and Alcohol
Authors: Sadr-Azodi Omid
Published: January 2023

Acute pancreatitis is the most common disorder of the pancreas. The incidence of the disease has increased markedly during the past decades. Whilst alcohol abuse and gallstone disease might explain a large proportion of the disease etiology, in one quarter of the patients, the cause remains unknown. Life-style and pharmaceutical drug use are potential risk factors for the disease. This brief review highlights the recent research on the role of these factors in the etiology of acute pancreatitis.
Pain Management in Patients with Sickle Cell Disease – A Review
Authors: Delicou Sophia , Maragkos Konstantinos
Published: January 2023

Pain is defined, by the International Association for the Study of Pain (IASP), as an ‘unpleasant sensitive and emotional experience, associated with or described in terms of tissue lesion’. It may be classified as acute or chronic when it becomes a symptom that worsens the quality of life, and thus loses its protective function. Pain may also be considered as chronic when it lasts over 3 to 6 months. Acute painful episodes, are the most common cause for patients with sickle cell disease (SCD) to seek medical attention. The causes of chronic pain are diverse in this population. In a sense, chronic sickle cell pain is a spin off the recurrent acute painful episodes. Pain management in patients with SCD presents unique challenges and opportunities.
Occupational Risks of Chronic Low Dose Radiation Exposure in Cardiac Catheterisation Laboratory: The Italian Healthy Cath Lab Study
Authors: Picano Eugenio , Andreass Maria Grazia , Piccaluga Emanuela , Cremonesi Alberto , Guagliumi Giulio
Published: January 2023

Contemporary interventional cardiologists have an exposure per person, per year, two to ten times higher than that of diagnostic radiologists. Cumulative doses after 30 years of working life are in the range of 50 to 200 mSv, with a projected professional lifetime attributable excess cancer risk in the order of magnitude of 1 in 100. Of special concern, the left side of the operator is more exposed (30% to 100%) than the right side, and less protected parts of the body (e.g. head and hands) can receive equivalent doses between 5 and 50 mSv per year.

Focused studies are clearly needed to define the occupational health risk of accumulated radiation exposure in catheterisation laboratories, particularly in respect of potential risk for circulatory diseases (i.e. heart disease and strokes) and effects on the cognitive function. This paper describes the rationale of the ongoing Healthy Cath Lab (HCL) Study, designed by interventional cardiologists, for interventional cardiologists. The Italian HCL project is a case-control study that will include a cohort of 500 highly exposed subjects (interventional cardiologists, nurses, and technicians working in the cath lab >3 years) and a ‘best match’ control group of 500 unexposed subjects. All aspects of in-room personnel radiation exposure (e.g. standard safety precautions, workload), as well the health status of each participant, will be investigated by using a web survey. In order to overcome the inherent limitations of the epidemiological approach, the relationship between radiation exposures and the risk of health effects will also be evaluated through ‘early warning’ signs, which are easy to measure and are capable to identify long-term risk for subsequent clinically overt disease. Examples of surrogate endpoints include chromosome aberrations analysis for cancer risk, carotid intima-media thickness and telomere shortening for atherosclerosis, and olfactory dysfunction for neurodegenerative disorders.

The HCL project will contribute in the defining of the potential occupational health effects of radiation exposure in cath lab, as well as strengthening ‘the culture of safety’ in the cath lab.
Factors Associated with Rehospitalisation for Cellulitis and How to Mitigate Against Them
Authors: Roberts Eleanor
Published: January 2023

Gavin Barlow, Hull York Medical School, UK, spoke with the EMJ about risk factors for the bacterial infection cellulitis, including prior history of the condition, older age, and a number of comorbidities ranging from diabetes to athlete’s foot. Following hospitalisation, readmission for cellulitis, which occurs in around 12% of patients in the first month, may be due to such risk factors, as well as socioeconomic conditions. Readmission can greatly impact healthcare utilisation in economic and infection control terms and the use of sparse facilities, such as side-room beds. It can also impact a patient’s quality of life (QoL). Mitigating against readmission for cellulitis necessitates an understanding of the reasons for such, including risk factors, and how best to control them by, for instance, giving proper healthcare provision for comorbidities and educating patients to raise awareness of the recurrence of cellulitis.
‘A Better Way to Measure Choices’ Discrete Choice Experiment and Conjoint Analysis Studies in Nephrology: A Literature Review
Authors: Clark Michael D. , Higgins Robert , Gumber Anil , Moro Domenico , Leech Dennis , Szczepura Ala , Daga Sunil , West Nick
Published: January 2023

Discrete choice experiments (DCE) and conjoint analysis (CA) are increasingly used to address health policy issues. This is because the DCE and CA approaches have theoretical foundations in the characteristics theory of demand, which assumes goods, services, or healthcare provision, can be valued in terms of their characteristics (or attributes). As a result, such analysis is grounded in economic theory, lending theoretical validity to this approach.

With DCEs, respondents are also assumed to act in a utility-maximising manner and make choices contingent upon the levels of attributes in DCE scenarios. Therefore, choice data can be analysed using econometric methods compatible with random utility theory (RUT) or random regret minimisation (RRM) theory. This means they have additional foundations in economic theory. In contrast, analyses described as CAs are sometimes compatible with RUT or RRM, but by definition they do not have to be.

In this paper we review the CA/DCE evidence relating to nephrology. The CA/DCE approach is then compared with other approaches used to provide either quality of life information or preference information relating to nephrology. We conclude by providing an assessment of the value of undertaking CA or DCE analysis in nephrology, comparing the application of CA/DCEs in nephrology with other methodological approaches.
New Approaches to Meet Patients’ Needs in Clinical Practice
Authors: Priddle Tom
Published: January 2023

Migraine is a primary headache disorder affecting up to four in ten women and up to two in ten men, mostly before the age of 35 years.1 By the age of 30, migraine is 3-times more prevalent in women than in men.1 The effects of migraine vary considerably, ranging from minimal disruption of daily activities to severe disability.1 Migraine without aura (MWoA) is most common, followed by migraine with aura (MWA).1 Attacks typically last 4-72 hours, with two or more specific features (unilateral location, pulsating, moderate-to-severe pain intensity, or aggravation by routine physical activity) during the attack. Migraine attacks are also accompanied by at least one of nausea, vomiting, and photophobia and phonophobia.1

It is 25 years since triptans first became available on prescription. Although their safety and efficacy is well established, there is still a great deal of ongoing research into the nuances of their use in treating patients with specific needs. Frovatriptan, in common with other triptans, is a serotonin (5-hydroxytryptamine, 5-HT) 1B/1D receptor agonist.1 Frovatriptan also shows moderate affinity for 5-HT7 receptors,1 resulting in more potent contraction of cerebral arteries than coronary arteries, with the potential for good efficacy and low risk of unwanted effects.1 Frovatriptan is distinctive from other triptans due to its half-life of 26 hours, which confers a longer duration of action.1
Motor System Plasticity and Compensation in Multiple Sclerosis
Authors: Zeller Daniel
Published: January 2023

Multiple sclerosis (MS) affects the central nervous system (CNS) by inflammatory lesions, direct axonal injury, and by a rather diffuse and widespread neurodegeneration. For a long time, research has mainly focused on these destructive aspects of MS, while the compensatory effects of cellular repair and neural plasticity have received little consideration. However, as current effective immunomodulatory therapies may limit rather than preclude demyelination and axonal damage, additional therapeutic strategies promoting compensation of CNS damage might be of great use for preventing persistent impairment in MS. As a precondition for the development of such strategies, which may encompass pharmacological and behavioural interventions, but also non-invasive stimulation techniques, it seems fundamental to get deeper insights into the mechanisms of plasticity and adaptation at the systemic level. This review will provide a brief overview of what is known about plasticity of the motor system in patients with MS at present, with the main focus relying on evidence from functional imaging, neurophysiology, and motor learning. Overall, rapid-onset motor plasticity seems to be preserved even in advanced stages of the disease. Reorganisation processes, which can be shown early in the course of MS, are functionally relevant for motor compensation. In advanced MS, however, the brain´s adaptive reserve might be exhausted due to exceeding CNS injury. Future studies should address the question of how the later stages of central motor plasticity can be promoted best to preserve the patient´s autonomy for as long as possible.
Imaging and Treatment Decisions in Seizures and Epilepsy
Authors: von Oertzen Tim J.
Published: January 2023

It has been clearly shown that magnetic resonance imaging (MRI) is the preferred modality of structural imaging for both new onset seizures and established epilepsy. MRI imaging in epilepsy requires a dedicated MRI protocol in order to detect subtle epileptogenic lesions such as focal cortical dysplasia or hippocampal sclerosis. Thin-slice thickness and orientation in the longitudinal axis of the hippocampus and perpendicular to it are the main characteristics of dedicated epilepsy MRI. An expert experienced in epilepsy and imaging should interpret epilepsy MRI. The new generation of 3 Tesla (T) MRIs is more sensitive, particularly for focal cortical dysplasia. Epilepsy-dedicated MRI is indicated particularly at the time of first seizure or new onset epilepsy, and when epilepsy becomes drug refractory. Results of a lesional MRI will assist in classifying the epilepsy syndrome and may well have an influence on treatment planning. Particularly in focal drug refractory epilepsies, a lesional MRI result may indicate a good hypothesis for presurgical assessment. If structural MRI is non-lesional, MRI post-processing may help to identify subtle epileptogenic lesions. CT scanning should only be performed in acute settings if MRI is not available or if the patient is too unwell for MRI scanning.
Intensity-Modulated Radiotherapy in the Treatment of Pancreatic Adenocarcinoma: A Review
Authors: Caravatta Luciana , Macchia Gabriella , Deodato Francesco , Felicetti Marco , Cellini Francesco , Ciabattoni Antonella , Buwenge Milly , Picardi Vincenzo , Cilla Savino , Scapati Andrea , Valentini Vincenzo , Morganti Alessio G.
Published: February 2023

Pancreatic cancer remains one of the leading causes of cancer deaths. Despite improvements in imaging, surgical techniques, chemotherapy agents, and radiation techniques, the prognosis for patients with pancreatic adenocarcinoma remains poor. Traditionally, radiotherapy (RT) has been utilised as neoadjuvant, adjuvant, or definitive treatment, and represents an important therapeutic option in pancreatic adenocarcinoma. Intensity-modulated radiation therapy (IMRT), a more recent RT technique, has the potential to deliver an adequate dose to the tumour volume with a minimal dose to the surrounding critical structures such as duodenum, small intestine, liver, kidneys, and spinal cord. This article provides a review about the role of IMRT in the treatment of pancreatic cancer, concerning clinical outcomes such as toxicity, local control, and overall survival.
LİMAN İŞLETMELERİNDE TEHLİKELİ MADDE ELLEÇLENMESİNE İLİŞKİN FİNE-KİNNEY VE FMEA YÖNTEMLERİ İLE RİSK ANALİZİ
Authors: YORULMAZ Murat , YEĞİN Ali Osman
Published: January 2023

Denizyolu taşımacılığının en çok tercih edilen taşıma yönetmelerinden biri olması nedeniyle liman işletmelerinde yaşanılan yoğunluk ve liman hizmetlerinin yapısı gereği, çalışan sayısı ve iş süreçleri fazladır. Bu nedenle liman işletmelerinde iş güvenliği, çalışanlar ve çevre açısından vazgeçilmez bir unsur olmaktadır. İş süreçleri ve yapılan faaliyetler nedeniyle liman işletmeleri iş güvenliği açısından birçok risk etmenini bünyesinde barındırmaktadır. Bu risk etmenlerinden en önemlilerinden biri olan tehlikeli madde elleçleme ve depolama operasyonu, başlı başına çok büyük tehlike unsurlarını bünyesinde barındırmakta, risk analizinin doğru yapılmaması ve güvenlik önlemlerinin yetersiz kalması sonucunda gerçekleşecek kazanın sonucu, yaşanan kazalardan da göz önüne alındığında birçok ölüm ve çevresel felaketle sonuçlanmaktadır. Böyle büyük bir felaketin yanı sıra işletmelerin uğradığı zarar, tehlikeli madde elleçleme ve depolamada risk analizinin ne kadar önemli olduğunu göstermektedir. Bu kapsamda çalışmanın temel amacı, liman işletmelerinde iş güvenliği açısından tehlikeli yük elleçlemesine ilişkin olası tehlikeleri belirlemektir. Bunun yanında belirlenen risklerin gerçekleşmemesi için uygulanması gereken yönetimsel önlemleri belirlemek çalışmanın diğer bir amacıdır. Bu amaçlara yönelik olarak da Fine Kinney ve FMEA (Hata Türleri ve Etkileri Analizi-Failure Mode Effects Analysis) risk analizi yöntemleri ile tehlikeli madde depolama ve elleçleme operasyonlarında tehlike unsurları belirlenerek, oluşturduğu risk unsurları tespit edilmiştir. Araştırma sonucunda, gerekli düzeltici ve önleyici faaliyetler belirlenip, riskleri minimuma indirmeye ve liman işletmelerinin yük operasyonlarında daha güvenli bir çalışma ortamı oluşturmaya yönelik önerilerde bulunulmuştur.
Reflections in Student Learning about Race and Racial Politics
Authors: Carroll Jeffrey
Published: January 2023

This paper examines lessons learned in teaching the course, Race and the American Political System. Surprisingly, assignments that were meant to be informal exercises meant to encourage reflection a weekly journal, a weekly voice memo, and a podcast ultimately captured a spirit of nuanced, deep and thoughtful investigation into race in America. To that end, this paper investigates the pros and cons of utilizing these assignments and considers their potential in conveying important student learning outcomes as it relates to racial politics. The paper relies heavily on student work in these assignments as tangible examples.