bluuebunny/crossref_metadata_2025 huggingface dataset:
1960 Sonrası Sanatçı Kitaplarının Dönüştürücü Etkisi Bağlamında Tom Phillips'in “A Humument” Eseri
Authors: Dere Mehmet , Dedeoğlu Şerafettin
Published: December 2023

Bu çalışma, sanat tarihinde kitap formunun önemine odaklanan bir derleme çalışmasıdır, özellikle 1960 sonrası sanat nesnelerini inceleyerek. Sanatçı kitaplarının süreçlerini ele alarak, Tom Phillips'in "A Humument" adlı eseri aracılığıyla metin ve görsel sanatın etkileşimini incelemeyi amaçlamaktadır. Çalışma, 1960 sonrası sanatçı kitaplarına odaklanmış ve özellikle Phillips'in "A Humument" adlı eserinin, mevcut bir romanın sayfalarını yeniden tasarlayarak ve orijinal metinden yeni anlamlar ve imgeler çıkararak nasıl dönüştürücü bir etki yarattığını detaylı bir şekilde incelemiştir. "A Humument," Phillips'in metni sadece anlam içermeyen bir yapı taşı olarak değil, aynı zamanda görsel bir ifade biçimi olarak ele aldığı yenilikçi bir sanat eseri olarak öne çıkar. Bu bağlamda, eser, sanatçı kitaplarının metin ve resim arasındaki ilişkiyi nasıl dönüştürebileceğine dair etkileyici bir okuma sunan bir örnek olarak değerlendirilmektedir. Çalışma, 1960 sonrası sanatçı kitapları ve Phillips'in eserini oluşturan kavram ve imge diyalektiğinin metinlerarası boyutunu tartışmaya açan bir analiz sunmayı amaçlamaktadır
Alternative pricing for irrigation water management in the context of climate change
Authors: Jeder Houcine
Published: December 2023

Irrigation water pricing is an economic regulation instrument widely used in agriculture. Constant annual pricing is always criticized by local decision-makers as well as scientific researchers because it does not take into account the seasonal availability of water in the context of climate change. This study proposes a mathematical programming model to test alternative seasonal pricing scenarios in the context of climate change. This model is applied at farm level in the Kalâa Kebira region of East-Central Tunisia. The results show that summer seasonal pricing was economically beneficial for large farms, while winter pricing was beneficial for small and average farms. Water savings were only possible for small farms using 89% of available water in summer and for average farms using 93% of available water in winter. On the other hand, the sensitivity test proved that when water demand is elastic, increasing seasonal pricing of irrigation water by a rate between 20 and 30% generates water savings for different types of farms. This seasonal water saving is also accompanied by optimal use of agricultural labor and diversity of cultivated areas.
Accelerated anti-oxidant enzymes and phytochemical potential of Taxus wallichiana (Himalayan yew) under moist temperate forest of Himalayan, Pakistan
Authors: Satti Sanam Zarif , Siddiqui Samina , Shahzad Asim , Shah Wadood
Published: December 2023

Taxus wallichiana (Himalayan yew) antioxidant potential enhances the release of secondary metabolites and enzymes under stress; over the last few decades owing to changes in climatic regimes, such species are under constant threat in the moist temperate Himalayan forests. The present study aims to evaluate the effect of change in land-use pattern on the antioxidant and phytochemical potential of T. wallichiana (Himalayan yew) in the moist temperate Himalayan Forest of Galiyat-Khyber-Pakhtunkhwa-Pakistan. Three leaf samples from each location of T.W were collected from high (Ayubiya, 2,970 m.a.s.l.) undisturbed, disturbed mid (Baragali, Dongagali, Kuldana, Chegagali, 2,617, 2,375, 2,455, 2,804 m.a.s.l.) and low (Murree, 2,000 m.a.s.l.) altitudes of moist temperate forest of Galiayt-Himalayan-Khyber-Pakhtunkhwa-Pakistan, DPPH assay, total flavonoids and phenolic content, total protein and proline content, catalase, superoxide dismutase and peroxidase activities were analysed. The antioxidant activity (DPPH) response was more pronounced in low and mid altitude disturbed sites than the undisturbed site at high altitudes. Antioxidant enzymes and osmolyte content further supported the stress tolerance capacity of T. wallichiana to scavenge the ROS produced under oxidative stress conditions. In conclusion, Taxus wallichiana inhabiting in these sites could withstand long durations of drought, salinity, frost, high temperatures, and pathogenic attacks by activating the antioxidant enzymes.
Evaluation of woodchips-amended biosand filter for nitrate and MS2 bacteriophage reduction
Authors: Jang Chunhwa , Zhou Hongxu , Araud Elbashir , Nguyen Thanh H. , Bhattarai Rabin
Published: December 2023

In this study, two types of woodchip-amended biosand filters (Filter A sand: woodchip = 33%: 67% versus Filter B sand: woodchip = 50%: 50%, by volume) were constructed, and their abilities to remove MS2 bacteriophage and nitrate were investigated. The results indicated that Filter A and Filter B could reduce nitrate up to 40 and 36%, respectively, indicating that the nitrate reduction increased with the increase in woodchip proportion. The study underscores a positive correlation between nitrate reduction and proportional increase in woodchip content, implying the potential for fine-tuning nitrate removal by varying sand–woodchip compositions. W-BSFs could remove MS2 bacteriophage to 1.91-log10 (98.8%) by Filter A and 1.88-log10 (98.7%) by Filter B over 39 weeks. The difference in sand–woodchip proportion did not significantly impact the MS2 reduction, demonstrating that a single W-BSF can maintain its virus removal performance fairly well over a long-term period. These results indicated that the nitrate reduction could be adjusted by varying sand–woodchip contents without impacting virus removal performance. Microbial community analysis indicated that the nitrate removal by the W-BSFs could be attributed to the denitrifying bacteria, such as the family Streptomycetaceae, the genera Pseudomonas, and Bacillus, and relative abundances of the phylum Nitrospirae.
Assessing the genotoxic potential of wastewater effluents from three wastewater treatment plants in South Africa
Authors: Hendricks Rahzia , Du Preez Hein H.
Published: December 2023

Wastewater treatment plants are mainly monitored for quality in terms of their biological oxygen demand and microbiological constituents as stipulated in the specific discharge permit. Wastewater influents and effluents were taken from three WWTPs in South Africa over the summer and winter seasons. Previous toxicity tests such as the Vibrio fischeri bioluminescence assay and the Selenastrum capricornutum algal growth inhibition test have shown that the effluents displayed acute toxicity. To further investigate the quality of the effluent, the genotoxic potential was determined using the SOS Chromosome and UMU Chromosome test. The SOS Chromotest demonstrated induction factor values of above 1.5 for influents during both seasons indicating that the influents were genotoxic (p < 0.05). Effluents discharged during winter and summer also had induction factors greater than 1.5 (p < 0.05). A range of induction factors was detected with the UMU-Chromotest for influents and effluents (1.98 ± 0.38 and 2.40 ± 0.51, respectively). Findings show point sources in the area can lead to influents and effluents that are potentially genotoxic. Designing a monitoring programme that encompasses testing of both the regulatory determinants with additional specialized tests can provide a more holistic view of wastewater quality and the efficiency of WWTP to reduce the discharge of hazards.
Integrated hydrological modelling of two contrasting watersheds with a terminal reservoir in the Upper Tapi River basin, India
Authors: Munoth Priyamitra , Gehlot Lalit Kumar , Patel P. L. , Khandelwal Sumit , Timbadiya P. V. , Goyal Rohit
Published: December 2023

The present study developed an integrated hydrologic model for sustainable utilisation and water management in two complex watersheds with varying physioclimatic features and reservoirs. The soil and water assessment tool (SWAT) is used for predicting integrated inflows into the Hatnur reservoir from the Burhanpur and Purna watersheds of the Upper Tapi River basin, while outflows are simulated using a rule curve. The influence of watershed complexities on hydrological model parameters and the watershed processes are investigated using extensive multisite and multivariable calibration (1998–2007) and validation (2008–2013) approaches, including sensitivity and uncertainty analyses. The sensitive parameters are related to curve number (CN), groundwater, slope, and main channel characteristics. The annual streamflow (m3/km2/mm of rainfall) in the Burhanpur watershed is 568.7, which is 4.2 times higher than the Purna watershed's streamflow of 136.2. The hypsometric analysis, areal rainfall, and flow duration curves revealed a substantially different streamflow pattern and a larger coefficient of variation in the spatial distribution of water balance components over sub-watersheds in the Burhanpur watershed compared to the Purna watershed due to diverse topographic features. The developed model would be useful for planning controlled releases from the terminal reservoir to mitigate hazards in the downstream reaches of the Tapi River basin.
Reflexões sobre a Consciência Fonológica no biletramento português/inglês na educação bilíngue
Authors: Molina Carolina , Petriu Ferreira Engelbert Ana Paula , Machry da Silva Susiele
Published: December 2023

Discussões acerca do ensino-aprendizagem de inglês como língua adicional (LA) no contexto de educação bilíngue no Brasil têm se expandido nos últimos anos. Contudo, estudos sobre aspectos específicos no processo de ensino-aprendizagem dessa LA e habilidades de Consciência Fonológica (CF) são escassos. Compreendendo a CF como habilidade de reflexão e manipulação da língua, discutimos questões teóricas sobre as habilidades de CF em inglês por crianças inseridas em contexto de educação bilíngue. Nossa compreensão é que a CF é importante para o sucesso no desenvolvimento da leitura e da escrita no processo bilíngue da criança, considerando que a reflexão sobre sons da língua materna (L1) pode acontecer no sistema fonológico da outra língua. Usando de uma metodologia bibliográfica e de pesquisa, trazemos uma revisão de literatura sobre a educação bilíngue no Brasil e o biletramento, bem como apontamentos sobre a CF na L1 e na LA.
Zabezpieczenie prawa nupturientów do intymności i ochrony dobrego imienia w trakcie bezpośredniego przygotowania do małżeństwa wg dekretu KEP z 8 października 2019 roku
Authors: Jakubiak Tomasz
Published: December 2023

Dla zapobieżenia nieważnemu i niegodziwemu zawieraniu małżeństw, na- rzeczeni przed wyrażeniem zgody małżeńskiej w Kościele katolickim na terenie Polski egzaminowani są zgodnie z normami promulgowanymi przez Konferencję Episkopatu Polski w Dekrecie ogólnym o przeprowadzaniu rozmów kanoniczno-duszpasterskich z na- rzeczonymi przed zawarciem małżeństwa kanonicznego z dn. 8 października 2019 roku W niniejszym artykule autor przeanalizował przepisy ogłoszone w przedmiotowym dekrecie pod kątem realizacji prawa nupturientów do zachowania własnej intymności i dobrego imienia. Ponadto wskazał duchownym przeprowadzającym egzamin przed- ślubny możliwe działania (w tym nieuregulowane wprost w obowiązującym prawie partykularnym), które pozwalają skuteczniej zabezpieczyć prawa nupturientów zapisane w kan. 220 KPK/83 wtedy, gdy podlegają one ograniczeniu ze względu na dobro wspólne, ius connubii przyszłych małżonków oraz obowiązek spoczywający na duszpasterzu ro- zeznającym zdatność nupturientów do zawarcia małżeństwa (kan. 1066-1067 KPK/83). Autor zaproponował również możliwe sposoby postępowania osób przeprowadzających egzamin, kiedy realizacja wspomnianych praw i obowiązków w trakcie spisywania pro- tokołu przedślubnego zdaje się być nie do pogodzenia.
Piotr Majer, Leszek Adamowicz, Praktyczny komentarz do dekretu ogólnego Konferencji Episkopatu Polski o przeprowadzaniu rozmów kanoniczno-duszpasterskich z narzeczonymi przed zawarciem małżeństwa kanonicznego z dnia 8 października 2019 r., Wydawnictwo Die
Authors: Poniatowski Michał
Published: December 2023

Recenzja publikacji naukowej
Compliance: um estudo bibliométrico sobre a aplicação dessas práticas na indústria de óleo e gás
Authors: Pires Antunes João Vitor , Padovani Xavier Thiago , Zuliani Mantegazini Diunay
Published: December 2023

O termo compliance, que, em inglês, significa conformidade passou a ter maior percepção a partir dos anos 2000, devido ao aparecimento de escândalos de desconformidade, particularmente em empresas americanas. As empresas do setor de óleo e gás (O&G) foram um dos principais alvos da Operação Lava Jato e para responder estrategicamente a fim de restaurar sua reputação, o setor criou a Comissão de Compliance do Instituto Brasileiro de Petróleo, Gás e Biocombustíveis (IBP), composta pelas principais empresas de O&G e pelo Instituto Ethos. Iniciativa que resultou na produção do Pacto de Integridade da Indústria de Óleo, Gás e Biocombustíveis e do Guia de Boas Práticas. Visto que se conhece a importância da aplicação da prática de compliance no setor específico, mas não se sabe o quanto se pesquisa sobre isso a pesquisa bibliométrica seria capaz de ter essa compreensão e investigar como as empresas respondem à aplicação dessa prática, que, aparentemente, esse retorno das empresas ainda não foi muito investigado pelas pesquisas. Com esse intuito a pesquisa foi realizada utilizando a base de dados da Web of Science, onde na primeira etapa da pesquisa, quando utilizou-se apenas o termo “compliance” foram encontrados 41.097 artigos publicados nos últimos 10 anos, que estão em revistas de todos os continentes, porém concentrados nos EUA e na Inglaterra. Ao restringir a pesquisa e adicionar o segundo termo, definindo o ramo industrial o qual é desejado pesquisar sobre compliance, óleo e gás, a pesquisa resultou em 108 artigos. Como o número ainda foi superior a 10, restringiu-se a pesquisa, então, aos 10 artigos mais citados dos 108 resultantes da pesquisa com o segundo termo. Somente 2 dos 10 artigos mais citados usavam o termo compliance como governança coorporativa, o qual é a intenção aqui.
A comparative study of different battery geometries used in electric vehicles
Authors: Hummes Diego Nieto , Hunt Julian , Hervé Bruno Barcellos , Schneider Paulo Smith , Montanari Pedro Marin
Published: December 2023

This paper contributes with a review of current and future electric vehicle battery geometries, as there are few comparisons regarding performance criteria in the literature. With these considerations, this paper seeks to fill this gap by comparing commercial batteries with different geometries. First, the specifications of each battery (found on manufacturers' websites or in specialized media) are presented. Then, the battery evaluation criteria are defined considering two distinct applications: economy and performance cars, using the Multi-Attribute Utility Theory (MAUT) method. From that analysis, the blade battery presented the best overall performance with a good rating for both applications. The cylindrical geometry followed with a rating suited better for performance vehicles, and the pouch geometry followed showing promise for use in economy-driven vehicles mostly. Lastly, a case study is carried out by evaluating the application of each of the batteries in a commercial vehicle. It was found that when compared to new technologies, the potential for improvement on any of the studied criteria is enormous. In particular, the Licerion pouch battery (Sion) showed the best performance regarding range and capacity-to-weight ratio, while the 4680 cylindrical battery (Panasonic) and blade battery (BYD) were superior in capacity-to-volume and capacity-to-cost ratios, respectively.
Advances in Research on Protein Arginine Methyltransferase 2: Functions
and Diseases
Authors: Min Zhen-Qi , Jiang Ming-Jun , Liu Xi-Lian , Yuan Su-Peng , Chen Ping-An , Wang Chu-Hao , Chen Ya-Jun , Dai Xian-Peng
Published: December 2023

Protein arginine methylation stands as a prevalent post-translational modification process,
exerting vital roles in cellular signal transduction, gene expression, and cell cycle regulation.
Amidst the protein arginine methyltransferase (PRMT) family, PRMT2 stands as a less explored
constituent. Nonetheless, its regulatory roles in transcriptional regulation, post-transcriptional modification,
methylation activity regulation, immunoregulation, and developmental regulation have
garnered attention. These capabilities enable PRMT2 to exert pivotal regulatory functions in certain
malignancies, metabolic disorders, inflammatory diseases, and atherosclerosis. In this review,
we highlight the structure and functions of PRMT2, emphasizing its association with diseases. We
also discuss PRMT2 inhibitors and explore the potential for therapeutic targeting.
Nanocomposite Hydrogels-A Promising Approach towards Enhanced Bioavailability
and Controlled Drug Delivery
Authors: Shahid Nariman , Erum Alia , Hanif Sana , Malik Nadia Shamshad , Tulain Ume Ruqia , Syed Muhammad Ali
Published: December 2023

Nanotechnology has emerged as the eminent focus of today’s research to overcome challenges related
to conventional drug delivery systems. A wide spectrum of novel delivery systems has been investigated
to improve the therapeutic outcomes of drugs. The polymer-based nanocomposite hydrogels (NCHs) that have
evolved as efficient carriers for controlled drug delivery are of particular interest in this regard. Nanocomposites
amalgamate the properties of both nanoparticles (NPs) as well as hydrogels, exhibiting superior functionalities
over conventional hydrogels. This multiple functionality is based upon advanced mechanical, electrical,
optical as well as magnetic properties. Here is a brief overview of the various types of nanocomposites,
such as NCHs based on Carbon-bearing nanomaterials, polymeric nanoparticles, inorganic nanoparticles, and
metal and metal-oxide NPs. Accordingly, this article will review numerous ways of preparing these NCHs
with particular emphasis on the vast biomedical applications displayed by them in numerous fields such as
tissue engineering, drug delivery, wound healing, bioprinting, biosensing, imaging and gene silencing, cancer
therapy, antibacterial therapy, etc. Moreover, various features can be tuned, based on the final application, by
controlling the chemical composition of hydrogel network, which may also influence the released conduct.
Subsequently, the recent work and future prospects of this newly emerging class of drug delivery system have
been enlisted.
Childhood Maltreatment and Dementia Risk Factors in Midlife: A
Prospective Investigation
Authors: Widom Cathy S. , Do Hang H. , Lynch Kristin S. , Manly Jennifer J.
Published: December 2023

Background:

Previous studies have linked childhood adversities to dementia risk, yet
most studies are cross-sectional in design and utilize retrospective self-reports to assess childhood
experiences. These design characteristics make it difficult to establish temporal order and draw
firm conclusions.

Objective:

Using a longitudinal design, we sought to determine whether childhood maltreatment
predicts dementia risk factors in middle adulthood.

Methods:

Data have been obtained from a prospective cohort design study of children with documented
cases of childhood maltreatment (ages 0-11 years at case identification) and demographically
matched controls who were followed up and interviewed in middle adulthood. Outcomes
were assessed through a medical examination and interview, and 807 of the cases that included
blood collection at mean age 41. Dementia risk were investigated using 11 potentially modifiable
risk factors.

Results:

Compared to controls, individuals with histories of childhood maltreatment had a higher
risk of low educational attainment, low social contact, smoking, and clinical depression, and a
higher total number of dementia risk factors. In general, childhood maltreatment predicted a higher
risk of dementia for females, males, and Black and White participants. Black maltreated participants
had a greater risk for traumatic brain injury compared to Black controls. Physical abuse, sexual
abuse, and neglect, each predicted a higher number of dementia risk factors in mid-life.

Conclusion:

These findings provide evidence that childhood maltreatment increases the risk for
dementia in mid-life and has a demonstrable impact lasting over 30 years. Reducing the prevalence
of mid-life dementia risk factors could reduce the risk of later-life dementia.
Recent Advances In Tacrine-Based Anti-Alzheimer’s Drug Design
Authors: Dorababu Atukuri
Published: December 2023

Alzheimer’s has become a common disease in aged people that leads to
cognitive impairment and finally results in dementia and death. As the disease has a
complicated etiology, it can hardly be prevented and cured. Hence, it turned out to be
one of the menacing neurodegenerative diseases. The important concerning factor
about Alzheimer’s is its unaffordable treatment cost. Also, there are only a few
efficient anti-Alzheimer drugs. Now, it is a very urgent need to discover the most
efficient and cost-effective anti-Alzheimer’s drugs. Nowadays, research reveals drugs
based on heterocyclic scaffolds that have attributed to potent pharmacology.
Quinoline-containing molecule, tacrine was recommended as an acetylcholinesterase
inhibitor. However, its use has been withdrawn because of its toxicity. While research
is going on designing derivatives of tacrine. Fortunately, some tacrine derivatives
showed the most potent anti-Alzheimer properties. In view of this, here, anti-Alzheimer
properties of recently reported tacrine-based Alzheimer’s agents are discussed and
evaluated. The structure-activity relationship has been helpful in identifying potent
molecules in a series of derivatives.
Diagnosis and Potential Strategies to Discover New Drugs for the Treatment of Alzheimer’s Disease (AD)
Authors: Manjunath Kavya , Kaur Arvinder , Bagur Parmesh Deepa , Murthy Shilpa
Published: December 2023

Alzheimer disease (AD) is most common cause of dementia, which is
characterized by impaired cognitive and behavioural charateristics. Deposition of Aβ
plaques and neurofibrillary tangs (NFTs) are the hallmark of AD. Generally it is a
chronic disease where neurodegeneration, and loss of neuronal function arise earlier
before it is diagnosed. Early detection of AD is important as it reduces the severity of
the disease. In this regard, an effective tools/methods are available including CSF
biomarkers, Magnetic Resonance imaging (MRI), Positron emission tomography (PET)
but all these methods are painful and often cannot be afforded by the patients.

Therapy of AD includes inhibitors of choline esterases, and antagonists at NMDA
receptors. From the studies it is shown that these drugs just offer relief from symptoms
rather than alleviating the progression of disease. Multiple pathological processes
contribute for AD, like oxidative stress, dysregulation of neurotransmitters,
inflammation of neurons, aggregation β-amyloid, phosphorylation of tau protein. It is
essential to target multiple causes for an effective outcome in the treatment of AD.
Early diagnosis is also crucial as it reduces disease progression thereby cost involved in
AD therapy.

This review focuses on non-invasive, patient affordable diagnosis methods and also
potential targets to discover new drugs beyond conventional and available drugs.
Bioinspired, Biomimetic Nanomedicines
Authors: Hamarat Şanlıer Şenay , Erek Ayça , Yılmaz Habibe
Published: December 2023

Bio-inspired nanotechnology (biomimetic nanotechnology) is defined as the
acquisition of nanomaterials or nanodevices and systems using the principles of
biology during design or synthesis. Transferring a mechanism, an idea, or a formation
from living systems to inanimate systems is an essential strategy. In this context,
nanoparticles inspired by nature have many advantages, such as functionality,
biocompatibility, low toxicity, diversity, and tolerability. It is known that biomimetic
approaches have been used in materials science since ancient times. Today, it plays a
crucial role in the development of drug delivery systems, imaging, and diagnostics in
medical science. There is no doubt that interest and research in biomimetic approaches,
which is an innovative approach and inspired by nature, will continue in the field of
medicine and life sciences hereafter. Within the scope of this chapter, polymeric
nanomedicines, monoclonal antibodies and related structures, cell and cell-membrane-derived biomimetic nanomedicines, bacteria-inspired nanomedicines, viral biomimetic
nanomedicines, organelle-related nanomedicines, nanozymes, protein corona, and
nanomedicine concepts and new developments will be elucidated.
Lipid-Based Nanocarriers and Applications in Medicine
Authors: Fulden Aydın Ümmühan , Tuli Abdullah
Published: December 2023

Lipid nanocarriers have recently arisen with a wide range of uses and
research areas, with the advantages they offer in virtue of their unique properties. They
are easily synthesized, scaled up, biodegradable, proper to transport many bioactive
components, have a high loading capacity, and are convenient for various routes of
administration (parenteral, oral, dermal, ocular, etc.). These carriers overcome the
problems of bioactive substances such as low solubility, plasma half-life and
bioavailability, and side effects, as well as providing controlled release, local delivery,
and targeting. Lipid-based nanoparticular systems can be categorized into two basic
classes, vesicular and non-vesicular. While liposomes are the most widely used
vesicular structures, solid lipid nanoparticles and nano-structured lipid carriers are non-vesicular nanocarriers. These nanocarriers have many medical uses, such as cancer
therapy, gene therapy, photodynamic therapy, treatment of infectious diseases and
neurodegenerative diseases, vaccines, imaging, etc. It is essential that the synthesis
method of lipid-based nanocarriers and the components from which they are composed
are selected in accordance with the medical application area and characterization
studies are carried out. In this article, liposomes, solid lipid nanoparticles and nano-structured lipid carriers will be discussed as lipid-based nanocarriers, synthesis and
characterization methods will be emphasized and examples from medical applications
will be given.
Nanoparticle Targeting Strategies In Cancer Therapy
Authors: Balyapan Hande , Ak Güliz
Published: December 2023

This review outlines major cancer targeting strategies for nanoparticle
systems. Targeted therapies have superiority over conventional chemotherapy or
radiotherapy methods. Nanoparticles as drug nanocarriers enable drug delivery to the
tumoral regions. For targeted drug delivery, nanoparticles are designed and tailored
depending on the cancer and the purpose of the targeting mechanism. In this review,
nanoparticle targeting for cancer therapy was summarized into three sections: passive,
active, and physical targeting. Each issue was described and discussed with recent
nanoparticular studies and their findings. In addition, a combination of targeting with
diagnostics and theranostics was also presented.
Novel Nanotechnological Therapy Approaches to Glioblastoma
Authors: Goker Bagca Bakiye , Biray Avci Cigir
Published: December 2023

Glioblastoma is one of the most aggressive and deadly types of cancer. The
blood-brain barrier is the biggest obstacle to overcome in glioblastoma treatment.
Nanomedicine, which describes the use of nanostructures in medicine, has significant
potential for glioblastoma. Nanomedicine provides advantages in crossing the blood-brain barrier, increasing the amount and effectiveness of drugs reaching the cancer site,
monitoring diagnosis and treatment through imaging agents, and increasing the
effectiveness of treatments in combination applications. This chapter reviews current
nanotechnology research in glioblastoma over the past few years. 
Role of Nano and Biopharmaceutics in Precision Medicine
Authors: Yılmaz Habibe , Erek Ayça
Published: December 2023

As our knowledge of developing technology and human biology increases,
the need for changes in our perspectives on diseases and treatment modalities has
emerged. The individual variation of diseases at the molecular level has long led to the
abandonment of the one-fits-to-all approach. These changes at the molecular level are
illuminated using -omics technologies and are among the most powerful tools in
precision medicine. The discovery of new drug targets and biomarkers results in the
structural elucidation of targets. Thus, it has been possible to develop new drug
molecules as well as to select the appropriate drug for the target, the appropriate dose,
and, when necessary, the appropriate drug combination. Awareness of the changes in
diseases at the molecular level has also updated clinical research designs to make
precision medicine applicable. In this section, information and examples of
developments in precision medicine, diagnosis and treatment in precision medicine, as
well as -omics technologies and other technologies are presented.
Operation Theatre Layout, Equipment Setup and Troubleshooting
Authors: Ramteke Harshal , Bhoyar Rohini , Sankhe Ashirwad , Yeshwant Ramrao Lamture
Published: December 2023

The surgical theatre is a vital and intricate setting where time and resources
are typically limited. Laparoscopic surgical procedures demand specific technical and
analytical skills from operating room personnel, as there is a high chance of mistakes
leading to potentially fatal repercussions in laparoscopic surgery [1]. The acquisition of
complete, precise, and appropriate knowledge about linkage and interaction between
human beings and laparoscopic equipment in operation theatre must be considered of
utmost importance. To avoid difficulties during surgery, a surgeon must become
familiar with this equipment and instruments [2].
Equipment for Creating And Maintaining the Pneumoperitoneum
Authors: Gianchandani Sanjeev , Keshwani Resha , Gianchandani Sachin , Yeshwant Ramrao Lamture
Published: December 2023

Creating and maintaining a pneumoperitoneum is a vital laparoscopy
procedure. A set of instruments, including an insufflator, are used to achieve
pneumoperitoneum. Despite having a critical role in laparoscopy, it is the least
understood of all laparoscopic devices and appliances. Co2
insufflator, also known as
an endoflator, and laproflator is the most intelligent laparoscopy device as it has to
work under control, considering physiology. In addition, gas cylinders, connector
tubing, dual valves and gas tubing are also utilized for creating pneumoperitoneum.
Energy Devices: Working Principles, Uses And Complications
Authors: Kamlakarrao Shinde Raju , Devrao Jogdand Sangita , Yeshwant Ramrao Lamture
Published: December 2023

In ancient times, a hot iron rod was used for charring at the bleeding site to
stop bleeding. The earliest significant contribution to a sophisticated method of
generating heat to cauterize tissue from electrical current is by Bovie. Energy sources
are classified as radiofrequency electrosurgery, laser, ultrasonic, and argon beam
coagulation. The majority (85%) of surgeons use monopolar electrosurgery. The
electrosurgical effect on the tissue causes cutting, coagulation, fulguration, and
desiccation. It uses ultrasonic technology, the unique energy form that allows both
cutting and clotting at the precise point of impact, resulting in minimal lateral thermal
tissue damage. Cutting and coagulation are done at lower temperatures than those used
by electrosurgery or lasers. The Harmonic Scalpel has five power levels. Increasing the
power level increases cutting speed and decreases coagulation.

In contrast, less power reduces cutting speed and increases clotting. Argon-enhanced
electrosurgery incorporates a stream of argon gas to improve the surgical effectiveness
of the electrosurgical current. Argon gas is inert and non-combustible, making it a safe
medium to pass electrosurgical current.
Robotic Surgery
Authors: Gajbhiye Varsha P. , Lamture Deepak , Yeshwant Ramrao Lamture
Published: December 2023

Primarily, it is a computer-assisted surgery. It's a modified future of
minimally invasive surgery. With this method, the surgeon makes decisions and gives
commands, and a robot carries out the surgery. The main advantage of robotic or
minimally invasive surgery is that instead of operating patients through large incisions,
patients get operated on through small incisions with less trauma to the tissue. There is
less pain and a shorter hospital stay with an early return to work. 
Public Service Performance: An Influence of Female Leadership and Good Governance
Authors: Rizki Tabah , Kurniawan Sindhunata
Published: December 2023

This research aims to analyze an influence of female leadership on public service performance moderated by good governance using the context of local government studies in Indonesia (districts and cities). The findings of this research increase our understanding of the influence of female leadership, public sector governance, and performance in local government service delivery. By using 4,910 local government observation data in Indonesia from 2009 to 2019, the empirical findings of this research showed that female leadership has a positive and significant influence on the achievement of public service performance. Furthermore, these results indicate that having female leadership can help the organization achieve better strategies and goals. In addition, good governance can strengthen the influence of female leadership on the performance of public services. This research implies that the existence of female leadership supported by good governance skills can provide maximum service to the public.
Vasıf Öngören' in “Asiye Nasıl Kurtulur?” Oyunu İzdüşümünde “Kadın” Ticaretinden “Kadının” Ticaretine Giden Sürecin Hukuk, Ticaret ve Toplumsal Cinsiyet Perspektifinde İncelenmesi
Authors: Bora Çınar Sevda
Published: December 2023

Asiye adlı kadının hikâyesini aktaran oyunlar ve oyunu izlemeye davet edilen bir dernek başkanının anlatıcıyla birlikte çözümleri tartıştığı konuşma bölümlerinden oluşan, Vasıf Öngören’in “Asiye Nasıl Kurtulur?” adlı oyunu, kadına dair pek çok meseleyi, topluma ayna tutarak yansıtan bir oyundur. Bu sebeple odağına bu oyunu alan çalışmamız da, öncelikle oyunun sistematiği ve anlatım tekniğine bağlı kalınarak ilgili bölümler kısaca özetlenmiştir. Sonrasında ise çalışmamızın özünü oluşturan inceleme başlığı altında, oyundan yola çıkılarak bölümlere ayrılan temel sorunlar, hukuk, ticaret ve toplumsal cinsiyet perspektifinde derinleştirilerek eleştirel bir bakış açısıyla ele alınmıştır. Çalışmamızla amaçlanan, kadına yönelik ayrımcılık, sömürü ve şiddetin kaynağı olan çifte standartlarla örülü toplumsal cinsiyet kalıplarının yalnızca kadın için değil toplumdaki her birey için önemli bir sorun olduğunu ortaya koymaktır.
Der: Pınar İlkkaracan, Müslüman Toplumlarda Kadın ve Cinsellik Adlı Eserinin Değerlendirilmesi
Authors: Günaydın Aykut
Published: December 2023

Kadının İnsan Hakları Projesi, Uluslararası New Ways Vakfı gibi çeşitli sivil toplum kuruluşlarının kurucu üyesi, psikoterapist ve araştırmacı kimliğine sahip olan Pınar İlkkaracan’ın Müslüman Toplumlarda Kadın ve Cinsellik adlı çalışması Türkiye, Filistin, Cezayir, İran gibi farklı ülkelerde kadın ve cinsellik üzerine yazılmış makalelerin bir araya getirilmesinden oluşmaktadır. Kadın ve cinselliğin Müslüman toplumlarda sosyo-kültürel, siyasi, dinî ve ekonomik bakımdan etkileri bu çalışmada yer verilen makalelerde farklı açılardan görülmektedir. Eser içerisinde “Önsöz” “Giriş” (Giriş bölümü makale ile birleştirilmiş), on üç makale ve yazarlar hakkında bir bölüm bulunmaktadır. Çalışma içerisinde yer alan makalelerden iki tanesi derleyici yazara ait olup diğerleri çeşitli coğrafyalardaki araştırmacılar tarafından kaleme alınmıştır.
Comparison of the Discrimination Performance of AI Scoring and the Brixia Score in Predicting COVID-19 Severity on Chest X-Ray Imaging: Diagnostic Accuracy Study
Authors: Tenda Eric Daniel , Yunus Reyhan Eddy , Zulkarnaen Benny , Yugo Muhammad Reynalzi , Pitoyo Ceva Wicaksono , Asaf Moses Mazmur , Islamiyati Tiara Nur , Pujitresnani Arierta , Setiadharma Andry , Henrina Joshua , Rumende Cleopas Martin , Wulani Vally , Harimurti Kuntjoro , Lydia Aida , Shatri Hamzah , Soewondo Pradana , Yusuf Prasandhya Astagiri
Published: December 2023

Background

The artificial intelligence (AI) analysis of chest x-rays can increase the precision of binary COVID-19 diagnosis. However, it is unknown if AI-based chest x-rays can predict who will develop severe COVID-19, especially in low- and middle-income countries.

Objective

The study aims to compare the performance of human radiologist Brixia scores versus 2 AI scoring systems in predicting the severity of COVID-19 pneumonia.

Methods

We performed a cross-sectional study of 300 patients suspected with and with confirmed COVID-19 infection in Jakarta, Indonesia. A total of 2 AI scores were generated using CAD4COVID x-ray software.

Results

The AI probability score had slightly lower discrimination (area under the curve [AUC] 0.787, 95% CI 0.722-0.852). The AI score for the affected lung area (AUC 0.857, 95% CI 0.809-0.905) was almost as good as the human Brixia score (AUC 0.863, 95% CI 0.818-0.908).

Conclusions

The AI score for the affected lung area and the human radiologist Brixia score had similar and good discrimination performance in predicting COVID-19 severity. Our study demonstrated that using AI-based diagnostic tools is possible, even in low-resource settings. However, before it is widely adopted in daily practice, more studies with a larger scale and that are prospective in nature are needed to confirm our findings.
Developing a Machine Learning Algorithm to Predict the Probability of Medical Staff Work Mode Using Human-Smartphone Interaction Patterns: Algorithm Development and Validation Study (Preprint)
Authors: Chen Hung-Hsun , Lu Henry Horng-Shing , Weng Wei-Hung , Lin Yu-Hsuan
Published: December 2023

BACKGROUND

Traditional methods for investigating work hours rely on an employee’s physical presence at the worksite. However, accurately identifying break times at the worksite and distinguishing remote work outside the worksite poses challenges in work hour estimations. Machine learning has the potential to differentiate between human-smartphone interactions at work and off work.

OBJECTIVE

In this study, we aimed to develop a novel approach called “probability in work mode,” which leverages human-smartphone interaction patterns and corresponding GPS location data to estimate work hours.

METHODS

To capture human-smartphone interactions and GPS locations, we used the “Staff Hours” app, developed by our team, to passively and continuously record participants’ screen events, including timestamps of notifications, screen on or off occurrences, and app usage patterns. Extreme gradient boosted trees were used to transform these interaction patterns into a probability, while 1-dimensional convolutional neural networks generated successive probabilities based on previous sequence probabilities. The resulting probability in work mode allowed us to discern periods of office work, off-work, breaks at the worksite, and remote work.

RESULTS

Our study included 121 participants, contributing to a total of 5503 person-days (person-days represent the cumulative number of days across all participants on which data were collected and analyzed). The developed machine learning model exhibited an average prediction performance, measured by the area under the receiver operating characteristic curve, of 0.915 (SD 0.064). Work hours estimated using the probability in work mode (higher than 0.5) were significantly longer (mean 11.2, SD 2.8 hours per day) than the GPS-defined counterparts (mean 10.2, SD 2.3 hours per day; P<.001). This discrepancy was attributed to the higher remote work time of 111.6 (SD 106.4) minutes compared to the break time of 54.7 (SD 74.5) minutes.

CONCLUSIONS

Our novel approach, the probability in work mode, harnessed human-smartphone interaction patterns and machine learning models to enhance the precision and accuracy of work hour investigation. By integrating human-smartphone interactions and GPS data, our method provides valuable insights into work patterns, including remote work and breaks, offering potential applications in optimizing work productivity and well-being.
Correction: Brachioradial Pruritus Due to Cervical Spine Pathology (Preprint)
Authors: Grabnar Maria , Tiwari Maneesh , Vallabh Jayesh
Published: December 2023

UNSTRUCTURED
Chiến lược nhắm mục tiêu vào DNA dựa trên cấu trúc các dẫn xuất chalcone mang dị vòng như là tác nhân chống ung thư tiềm năng
Authors: Nguyễn Cường Quốc , Lê Đăng Quang , Hứu Hữa Bằng , Nguyễn Ngọc Lê , Nguyễn Duy Tuấn , Bùi Thị Bửu Huê , Nguyễn Trọng Tuân , Trần Thanh Mến , Trần Quang Đệ
Published: December 2023

Khung sườn chalcone đóng vai trò quan trọng trong công cuộc thiết kế các loại thuốc chống ung thư. Trong nghiên cứu này, các dẫn xuất chalcone chứa hợp chất dị vòng là quinazolinone, benzimidazole, benzoxazole và 1,3,4-oxadiazole với hoạt tính chống ung thư tiềm năng đã được xem xét về khả năng gắn kết với DNA. Các hợp chất cho kết quả xen kẽ vào DNA chặt so với hợp chất đối chứng trên phương diện cấp độ phân tử. Mô phỏng động lực học đã được thực hiện cho bốn phức hợp tốt nhất, kết quả cho thấy sự ổn định về cấu trúc đã được gắn kết ở các phức hợp phối tử-DNA. Dự đoán về ADMET cũng đã được thực hiện cho các phối tử này. Tóm lại, nghiên cứu này khuyến khích tổng hợp các hợp chất chalcone chứa dị vòng, nghiên cứu khả năng tương tác với DNA và hiệu quả gây độc tế bào của chúng bằng các mô hình thực nghiệm in vitro. Nhóm hợp chất này có thể hữu ích cho việc phát triển các tác nhân hoặc thuốc chống ung thư đa mục tiêu mới và tiềm năng trong tương lai.
Tuyển chọn và định danh chủng vi khuẩn acid lactic có tiềm năng probiotic từ trái sơ ri (Malpighia glabra L.)
Authors: Huỳnh Ngọc Thanh Tâm , Huỳnh Yến Nhi , Lâm Cảnh Tân , Nguyễn Thành Bi
Published: December 2023

Nghiên cứu được thực hiện nhằm tuyển chọn được các chủng vi khuẩn có tiềm năng probiotic từ trái sơ ri (Malpighia glabra L.). Kết quả tuyển chọn được 9 chủng vi khuẩn có khả năng chịu được pH 2,5 trong đó chủng vi khuẩn HC1 có khả năng sống sót tốt nhất với mật số là 4,73 logCFU/mL. Nghiên cứu đã tuyển chọn được ba chủng vi khuẩn HC1, KA2, TB5 có khả năng chịu muối mật cao nhất. Các chủng vi khuẩn HC1, KA2, KA3, KA4, TB4 và TB5 có khả năng kháng ba loại kháng sinh là tetracyclin (30 µg/mL), ampicillin (10 µg/mL) và ofloxacin (30 µg/mL). Chủng vi khuẩn HC1 và KA4 có khả năng tự kết dính cao nhất với tỷ lệ kết dính lần lượt là 49,35% và 48,69%. Hơn thế nữa, ba chủng vi khuẩn HC1 có khả năng kháng vi khuẩn Escherichia coli với đường kính vòng vô khuẩn (ĐKVKK) lần lượt là 7,27 mm. Qua các thử nghiệm kiểm tra tiềm năng probiotic, HC1 là chủng vi khuẩn tiềm năng được chọn để giải trình tự gene 16S RNA, kết quả cho thấy chủng vi khuẩn này là chủng Lactiplantibacillus plantarum với độ tương đồng đạt 97,20%.
Đánh giá hiệu quả của một số vật liệu hữu cơ tươi lên sinh trưởng, năng suất hoa hồng và đặc tính sinh học đất ở điều kiện nhà lưới
Authors: Nguyễn Thị Tuyết Hoa , Nguyễn Khởi Nghĩa , Lê Thị Xã
Published: December 2023

Vật liệu hữu cơ như bã cà phê, vỏ trứng, phân bò, bèo hoa dâu… có giá trị dinh dưỡng cao giúp cải tạo đất, tăng sinh trưởng cây trồng, nhưng nghiên cứu đánh giá hiệu quả của nó lên sinh trưởng cây hoa hồng chưa phổ biến. Mục tiêu của nghiên cứu nhằm đánh giá hiệu quả vật liệu hữu cơ tươi gồm: bã cà phê, vỏ trứng, lông vũ, phân bò, bèo hoa dâu và xỉ than lên sinh trưởng, năng suất của hoa hồng và một số đặc tính sinh học đất ở điều kiện nhà lưới. Thí nghiệm được thực hiện trong sáu tháng với 6 nghiệm thức và 4 lặp lại. Vật liệu hữu cơ và phân hữu cơ thương mại được bón với liều lượng 4% (so với khối lượng đất khô), vào thời điểm 0, 40, 80 và 120 ngày sau khi trồng. Kết quả thí nghiệm cho thấy hỗn hợp hữu cơ tươi gồm bã cà phê, vỏ trứng, bèo hoa dâu, phân bò, lông vũ và xỉ than với tỉ lệ 1:1:1:1:1:1 giúp gia tăng chiều dài cành cây hoa hồng, số lá, đường kính hoa, số hoa và khối lượng hoa/chậu tốt nhất. Bên cạnh đó, các đặc tính đất như pH, EC trong đất cũng như thành phần sinh học đất gồm mật số vi khuẩn và mật số nấm được cải thiện và gia tăng đáng kể ở các nghiệm thức bón vật liệu hữu cơ tươi.
Hiệu quả của một số biện pháp phòng trừ tuyến trùng ký sinh rễ cây cam quýt theo hướng thân thiện với môi trường
Authors: Nguyễn Bá Phú , Nguyễn Quốc Tịnh , Nguyễn Quốc Sĩ , Lê Thị Tú Anh
Published: December 2023

Nghiên cứu này nhằm xác định hiệu quả của một số biện pháp phòng trừ tuyến trùng ký sinh rễ cam quýt thân thiện với môi trường. Thí nghiệm được bố trí hoàn toàn ngẫu nhiên với 22 nghiệm thức: đối chứng; dung dịch Ca(OH)2, KOH (pH: 10, 11, 12); dịch trích cây sài đất, lá neem, lá tràm ta nồng độ 10%, 20% và 30%; nấm Paecilomyces lilacinus 10, 20 và 40 kg/ha; nấm Trichoderma sp. 20, 40 và 80 kg/ha, mỗi nghiệm thức có 5 lần lặp lại. Dung dịch Ca(OH)2 (pH: 11 và 12), dịch trích cây sài đất, lá neem, lá tràm ta nồng độ 10%, 20% và 30% cho hiệu quả nhanh nhưng giảm dần theo thời gian, hiệu quả phòng trừ tuyến trùng ký sinh trong đất đạt 67,8 – 86,5% (20 ngày sau khi xử lý - NSKXL), ở rễ đạt 59,8 – 89,4% (100 NSKXL). Dung dịch Ca(OH)2 (pH: 10) và KOH (pH: 10, 11 và 12) có hiệu quả nhanh, trong đất đạt 51,6 – 60,3% (20 NSKXL), kéo dài đến 40 và 60 NSKXL sau đó giảm dần, ở rễ đạt 59,1 – 66,9% (100 NSKXL). Nấm Paecilomyces lilacinus (10, 20 và 40 kg/ha) và nấm Trichoderma sp. (20, 40 và 80 kg/ha) có hiệu quả chậm hơn và tăng dần theo thời gian, ở 100 NSKXL, hiệu quả phòng trừ tuyến trùng ký sinh trong đất đạt 69,6 – 80,4% và ở rễ đạt 59,7 – 82,9%.,...
Translanguaging in Linguistic Landscape of Historical and Cultural Streets
Authors: Chen Wanyi
Published: December 2023

Under the influence of globalization, multilingualism has become the way of social communication. Linguistic landscape in public space is complex and diverse with blurred boundary of languages. The interaction of multimodality and languages increase complexity of linguistic landscape. From the perspective of translanguaging, language practice on linguistic landscape not only transcends individual languages, but also goes beyond words, involving diverse semiotic resources. Through application of the concept of translanguaging, we can explore how different linguistic forms, signs and modalities co-occur to express meaning. Linguistic landscape in historical and cultural streets is an important window of the identity of the city. The linguistic landscape of historical and cultural streets shows a common diversity of language, culture and identity, reflecting obscure boundary of languages. The multilingual hybridity implies the conflicting and complex negotiation of multiple identity in the new stage of seeking for local development under economic globalization and urbanization. It is worth analyzing how the linguistic landscape of historical and cultural streets transcends semantic resources of different languages, varieties and multimodality to build a local identity.