bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Methods to Enhance Solubility of Water Insoluble Drugs
Authors: Tawar Mukund , Raut Kiran , Chaudhari Reshma , Jain Nikita
Published: June 2022

Orally directed medications totally ingest just when they show reasonable dissolvability in gastric medium and such medications shows great bioavailability. The solvency and disintegration properties of medications assume a significant part during the formulation development. Greater part of the disappointments in the new medication improvement have been credited to poor water dissolvability of medication. It is widely accepted that poor water dissolvability is quite possibly the most every now and again experienced troubles in the field of pharmaceutics. Low solvency and ensuing unacceptable disintegration rate regularly bargain oral bioavailability. There are most remedial specialists used to create fundamental impacts by oral course that are the favored method of organization inferable from its few benefits and high quiet consistence contrasted with different courses. Thusly the current methodologies being utilized for BCS class II medications, along with retention enhancers, can be applied to detail class IV compound. Effervescent Assisted Fusion Technique, Solvent Evaporation method, Microemulsion, Liposomes are some imperative methodologies regularly utilized to improve the dissolvability of ineffectively water dissolvable medications. Determination of technique for solvency upgrade relies on drug qualities like dissolvability, substance nature, melting point, retention site, actual nature, pharmacokinetic conduct, etc, measurement structure necessity like tablet or capsule formulation, strength, quick or modified release. This review features the novel strategies accessible for improving solvency, disintegration and bioavailability of medications with poor fluid dissolvability.
Development and Validation of New Analytical Method for Estimation of Anti-histamine in Tablet Dosage Form
Authors: Gudadhe Kalyani , Tawar Mukund
Published: June 2022

A rapid, sensitive and accurate method for Estimation of Anti- Histamine in Tablet Dosage Form by RP-HPLC. Mobile phase was Methanol: 0.1%. Ortho phosphoric acid (80:20% v/v). Flow rate was 0.9ml/min. The detection Wavelength was 227nm. The injection volume was 20µl.The proposed method was validated for selectivity, precision, linearity, and accuracy. All validation parameters were within the acceptable range. Linearity studies for Rupatadine Fumarate were performed (10-60µg/ml). The %RSD for accuracy found to be less than 2%. Assay was found to be 99.17 to 101.65 respectively. The range of 10-60µg /ml was selected for the linearity of a standard Rupatadine Fumarate. The 80%, 100% and 120% levels of recovery study were selected to perform the recovery study. Linearity studies for Rupatadine Fumarate was performed on (10-60µg/ml).
Effect of Vitamin C Adjuvant Therapy on Lipid Profile in Diabetes patients with Co-Morbid Cardiovascular Disease
Authors: P. Geetha , M. Varaprasannarao , D. Subalakshmi , Bergin R. V. Bibi
Published: June 2022

The study was aimed to evaluate the effect of Vitamin C adjuvant therapy significantly on lipid profile and HbA1c in diabetes patients with co-morbid cardiovascular disease.A total of 64 diabetic patients were enrolled by using a randomization procedure and assigned to control group and an intervention group.Patients in the intervention group received Vitamin C 500mg bid supplementation along with antidiabetic and antihyperlipdemic therapy as per the standard treatment protocol for a period of three months, whereas patients in the control group received only antidiabetic and antihyperlipidemic therapy for a period of three months. The mean age, BMI, duration of diabetes, of the subjects were 50.04±14.58, 27.94±4.71 and 9.93±4.83 respectively. The incidence of elevated CRP was found to be 68%. No statistically significant difference for any variable of comparison of glucose, lipid parameters and CRP was detected at baseline. There was a reduction in levels of clinical variables found after 3 months of daily use of vitamin C 500mg bid in the intervention group. Based on the results of this study concluded that Vitamin C as an adjuvant therapy produces beneficial effect in type 2 diabetes patients. Vitamin C 1g/day showed improved lipid profile which helps in cardiovascular risk mitigation.
Hydrotropy: A Promising Tool for Solubility Enhancement
Authors: G. Kalyani , P. Bhuvaneswari , B. Hemalatha , K. Padmalatha
Published: June 2022

Solubility is one of the key parameters to attain desired concentration of drug in systemic circulation to show pharmacological response. Various methods are engaged to augment the aqueous solubility of poorly water-soluble drugs and hydrotropic solubilisation is one of them. Hydrotropy is defined as a solubilization process whereby addition of a large amount of second solutes results in an increase in the aqueous solubility of another solute and chemicals which are used in the hydrotropy are called hydrotropes like sodium benzoate, sodium citrate, urea, niacinamide etc. Based on advantages like the high selectivity, independent of pH and cheap, easy availability makes this technique more prevailing than other solubilisation methods. Mixed hydrotropy is a solubilisation technique to augment the water solubility of poorly water soluble drugs by the way of different ratio of blends of hydrotropic agents which gives synergistic augmentation effect. The purpose of this review article is to illustrate the need for solubility, hydrotropic solubilisation, mechanism of action of hydrotrope, classification of hydrotropes, advantages and mixed hydrotropic technique of solubilisation for improving the solubility which in turn helps to attain absorption and improved bioavailability.
Efficacy and safety of pembrolizumab monotherapy in advanced non-small cell lung cancer patients treated at Hanoi Medical University Hospital
Authors: Huy Trinh Le , Trần Đình Anh
Published: June 2022

This study evaluated the efficacy of pembrolizumab monotherapy response rate and progression-free survival and its tolerabilty in advanced non-small cell lung cancer patients. Thirty patients with lung cancer in metastatic or recurrent settings were treated with pembrolizumab monotherapy at Hanoi Medical University Hospital from October 2017 to October 2021. The mean age was 65.37 ± 5.46 (40-81). Most patients were male (86.7%). Most had non-squamous cell carcinoma (70%) and a Tumor Proportion Score (TPS) ≥ 50% (63.3%). The complete response rate was 3.3%, the partial response rate was 36.7%, and the stable disease rate was 43.3%. The overall control rate was 83.3%. Patients with TPS ≥ 50% had significantly higher response rate (47.4% vs 27.3%, p > 0.05). Median PFS was 9.6 ± 0.84 months; the figure for patients with TPS ≥ 50% was higher than for patients with TPS 1-49% (10.9 months vs. 7.2 months), p < 0.05. Only 6.2% had hyperthyroidism, and 3.1% had hypothyroidism, all in grade I. Therefore, pembrolizumab treatment in advanced non-small cell lung cancer is effective with a high disease control rate and is well-tolerated.
Clinical features, microbiology, and vancomycin regimens in sepsis patients: A retrospective study conducted at a single infectious diseases center
Authors: Huong Tran Thu , Hoc Tran Hieu , Cuong Ngo Chi , Son Tran Que
Published: June 2022

Despite increasing antibiotic resistance, vancomycin remains the first choice to treat severe infections due to drug-resistant gram-positive bacteria. This study aimed to summarise the clinical, microbiological, and vancomycin treatment outcomes in bacteremia patients. From July to December 2019, a retrospective cohort analysis was conducted on patients with bacteremia treated with vancomycin at a tertiary hospital in Hanoi, Vietnam. Patients without vancomycin concentrations were excluded from the study. Patients had a median age of 54 years (IQR, 41.8 - 63.3), with a male/female ratio of 1.86. Renal complication was markedly different; Clcr < 60, 60 - 130, and > 130 mL/min was 29%, 60%, and 11%, respectively. The median Charlson score was 3.0 (2-4.3), the qSOFA score was 1 (1-2), and the NEWS score was 76%, with a median of 6 (5-8). Twenty-one cases had positive blood culture where85.7% were gram-positive. 93% of patients with sepsis were treated with vancomycin as the first antimicrobial, of which 72% used vancomycin in combination with other antibiotics. Renal complications occurred in 12% of all patients, with grades R, I, and F accounting for 4%, 5%, and 3%, respectively. The median duration of treatment was 12 days (IQR, 7-17), with a success rate of 82 % and a failure rate of 18%, respectively.
Conclusions: In most patients with bacteremia, microbiological tests reveal no detectable bacteria. When sepsis is suspected, a vancomycin regimen should be initiated.
Communication clarity, Communication confidence, and Communication skills of Nursing Students with Simulation-based SBAR Communication Education: Using the scenario for Infants & Early Childhood
Authors:   Form of Public Safety and Culture, Kim Dong Won , Shin Jeong Soon
Published: June 2022

This study was attempted to identify the differences in communication clarity, communication confidence, and communication skills of nursing students who received simulation-based SBAR (Situation, Background, Assessment, Recommendation) communication education. To provide basic data for systematic SBAR communication education to improve communication competency of nursing students. We used fever care scenario of urinary tract infection for infant childhood and dyspnea care scenario of pneumonia for early childhood. This is a single-group pre- and post-experimental design study. This study was conducted on 85 fourth-grade students who took simulation practice courses enrolled in the nursing department of one university located in B city. The data were collected from September 3 to December 6, 2021, using a self-report questionnaire before and after simulation practice. For data analysis, using SPSS/WIN 24.0 program, Communication clarity, communication confidence, and communication skills of nursing students were analyzed with the mean and standard deviation, and differences in communication clarity, communication confidence, and communication skills before and after SBAR communication education were analyzed using t-test. As a result of the study, communication clarity averaged 3.91±0.70 points before education and 4.37±0.66 points after education, and communication confidence averaged 7.56±1.42 points before education and 8.19±1.48 points after education. Communication skills averaged 3.96±0.44 points before education and 4.12±0.44 points after education. Communication clarity before and after SBAR communication education based on simulation (t=-4.37, p<.001), communicator confidence (t=-2.83, p=.005), communication skills (t=-2.46, p=.015) showed a statistically significant difference. Based on the results of this study, it will be necessary for nursing universities, which are prospective nurses, to actively use the SBAR communication format in various subjects from the lower grades for systematic education on communication.
Effects of Short-term Overseas Medical Service Activities on Nursing Students' Emphatic Ability, Self-leadership, Spiritual Well-being, and Cultural Competence
Authors:   Form of Public Safety and Culture, Hyeon Sa Saeng , Yang Hee Mo
Published: June 2022

This study was attempted to understand the effect of overseas short-term medical volunteer activities on the empathy ability, self-leadership, spiritual well-being, and cultural competence of nursing students.
Among the nursing students from four local universities who participated in the overseas short-term medical volunteer program, a preliminary survey and a follow-up survey were conducted on students who agreed to the research participation agreement in writing, and the final study subjects were 34. The collected data were analyzed using the SPSS WIN 21.0 program. The reliability of the tool was calculated with the Cronbach's α value. For the general characteristics of the subject, frequency and percentages were obtained, and the subject's empathy ability, self-leadership, spiritual well-being, and cultural competencies were obtained by means and standard deviation.
After reviewing the normality of the subjects' preliminary survey scores for overseas short-term medical volunteer activities using Shapiro-Wilk test, the normality was satisfied, and the difference in pre- and post-score was analyzed as a paired t-test. The correlation between the subject's empathy ability, self-leadership, spiritual well-being, and cultural competency after short-term overseas medical volunteer activities was analyzed as Pearson's correlation coefficient.
After participating in the program, the self-leadership of the study subjects had higher post-scores than the dictionary, but was not statistically significant, and there were significant differences in empathy, spiritual well-being, and cultural competencies. In addition, each variable showed a significant positive correlation with each other.
This study included major areas in existing volunteer activities for nursing college students and was developed to strengthen students' global capabilities by expanding the place of volunteer work from Korea to abroad, which had an effect on the improvement of subject empathy, self-leadership, and cultural capabilities. However, many of the subjects who participated in this study recognized the importance of religion, and high life satisfaction, so it is difficult to see the results of this study as the pure effect of overseas medical service programs. Also because it was made up of a single object without a control group. You should be careful in generalizing the results of this study.
In future studies, a study is suggested to verify the effectiveness of the program through the setting of a control group to more clearly confirm the effectiveness of the program, the expansion of the study subjects, and controlled experimental design.
Impact of Conservative and Operative Treatment on Functional Consequences in Patients with the Fracture of Metacarpals Bones: A Longitudinal Study
Authors: Bhutto Ali Muhammad , Saqlain Hassan Amir Us , Bhayo Azizullah , Mahar Sijad Ahmed , Bhatti Rasheed Ahmed , Soomro Nisar Ahmed , Keerio Niaz Hussain
Published: June 2022

Aim: The aim of this study was to compare the healing and functional outcomes of metacarpal bone fractures treated conservatively versus surgically. Study design: A longitudinal study Place and Duration: This study was conducted at Ghulam Mohammed Mahar Medical College Sukkur Pakistan. from June 2020 to June 2021 Methodology: The study comprised a total of 80 people with varied forms of metacarpal fractures. The fractures were treated conservatively or surgically in the orthopedic department. The Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire score, which was used to assess the ability to execute various tasks, inspired the creation of the questionnaire. The least level of disability was assigned a score of 0, and the most degree of disability was assigned a score of 100. Results: In the DASH questionnaire, a scale score ranging from Zero to 100 was calculated. The greater the score, the worse the scenario. The majority of the subject obtained a score of 21 to 25, suggesting that they were generally pleased with their therapy. The Michigan questionnaire was used to assess patient satisfaction as the next questionnaire. Patients' primary expectation is restoring maximum hand function, and the functional outcome is critical. Conclusion: Most metacarpal fractures have a satisfactory outcome with nonoperative therapy because there is a lot of tolerance for angulation and shortening. Physical therapy and mobilization are critical components of treating these fractures and are an important part of the rehabilitation process. More study is required to help develop a definite treatment regimen while maintaining our patients' quality of care and overall wellness. Keywords: Fracture, Metacarpals, Conservative Treatment,
Steroid Injections Versus Autologous Blood Injections: Treatment Analysis in Plantar Fasciitis Patients: A Randomized Controlled Trial
Authors: Soomro Nisar Ahmed , Bhatti Rasheed Ahmed , Mahar Sijad Ahmed , Bhayo Azizullah , Saqlain Hassan Amir Us , Bhutto Ali Muhammad , Keerio Niaz Hussain
Published: June 2022

Aim: To compare the effectiveness of autologous blood injection versus steroid injection, in the treatment of Plantar Fasciitis. Study Design: A Randomized Controlled Trial Place and Duration: This study was conducted at Alhada Armed Forces Hospital Taif KSA from January 2021 to July 2021. Methodology: A total of 44 participants who had plantar fasciitis, for more than 6 weeks were divided into two groups. Group A was treated with autologous blood injections and the other group with steroid injections. Those patients with plantar fasciitis who were gone through certain surgical (heel surgery, ankle dislocation, rupture of plantar fascia, calcaneal fracture, tarsal bone fracture, and metatarsal bone fracture) procedures prior to having the disease were excluded from the study. Result: The total number of males in Group A and Group B were 23 and 19 respectively. The total number of females in Group A and Group B were 21 and 25 respectively. Treatment through autologous blood was effective in 26 patients of Group A and treatment through steroids was effective in 31 patients of Group B. Group A and Group B consisted of individuals that had average ages of 37 years and 38 years respectively. Conclusion: Autologous blood injections were not more effective than steroid injections in the treatment of plantar fasciitis. Keywords: autologous blood injection, effectiveness, steroid injection, plantar fasciitis
Reasons and Sources of Hesitancy Against COVID-19 Vaccine: A Cross-Sectional Study among General Public in Pakistan
Authors: Usman Ali , Qureshi Areeba Arshad , Munawar Areeha , Mujeeb Areeba , Naseer Humna , Fatima Tahreem , Qadeemi Mohammad Amin , Arshad Sohail , Nursi Hekmatullah , Haider Romail , Sohaib Muhammad
Published: June 2022

Introduction:Since Coronavirus Disease-2019 (COVID-19) is a respiratory infection which is transmitted by respiratory droplets, it has now spread all across the globe. There are various myths and misconceptions about this vaccination that act as a prime barrier to vaccinate majority of the population. Methods: A cross-sectional-study was performed from all over Punjab province using convenience sampling technique. A sample size of 400 was gathered in this study by o digital and hardcopy questionnaires after the participants gave their consent. Results: The willingness to vaccinate against COVID-19, was only 28.0% while the greater remainder of 72% opted for ‘no’ or ‘maybe’. Our study prevailed that the most common reason of hesitancy among the population was that vaccine can cause blood to clot and people may die (15.6%). And the most frequent source emerged to be social media by 23%. Discussion: The study revealed that people with no or low educational status were more uncertain or hesitant towards vaccine administration as well as those belonging to ages 41-50 years.
Frequency of Number of Dialysis Done in Patients with CKD and then Compare the Frequency of HCV Infection in Patients with CKD on Hemodialysis
Authors: Waseem Muhammad Azhar , Saleem Sonia , Younis Muhammad Yasir , Khan Saad Hassan , Jabbar Sadia , Ullah Asmat
Published: June 2022

Objective: To assess the frequency of number of dialysis done in patients with CKD and then compare the frequency of HCV infection in patients with CKD on hemodialysis Study Design: Cross sectional study Setting: Medical Unit I, Department of Gastroenterology, Lahore General Hospital, Lahore. Duration: The study was conducted for a period of six months from 15th December, 2017 to 18th June, 2018. Methodology: A total of 120 patients were included in the study. Then number of dialysis done was also noted. Blood sample was sent to the pathology laboratory and HCV was labeled. All the data was recorded on proforma. Data was analyzed with IBM-SPSS version 21. Results: In this study, the mean age of patients was 47.47±18.65years. There were 56 (46.7%) male while 64 (53.3%) female patients. The mean BMI of patients was 22.62±4.04kg/m2. In this study, 57 (47.5%) had <50 dialysis sessions, 40 (33.3%) had 50-100 sessions, 14 (11.67%) had 101-200 sessions and 9 (7.5%) had >200 sessions. In patients with <50 dialysis, 10 (17.5%) had HCV, patients with 50-100 dialysis, 9 (22.5%) had HCV, patients with 100-200 dialysis, 7 (50%) had HCV and patients with>200 dialysis, 5 (55.6%) had HCV. The difference was significant (p<0.05). Conclusion: The frequency of HCV was significantly higher in patients with >100 sessions of dialysis as compared to <100 dialysis sessions. Keywords: Hemodialysis, Chronic Kidney Disease, Hepatitis C Virus, Sessions
Outcome of Acute Renal Failure in Neonates and Its Associating Factors
Authors: Anwar Hamayun , Heemal Momna , Khan Zarmast , Bhatti Zafariqbal
Published: June 2022

Objective:To identify various predisposing causes and immediate consequences in new-borns presenting with acute renal failure. Study design: The study design was case series. Place & duration:In the Pediatric department of Shifa International Hospital, Islamabad for one-year duration from September 2020 to August 2021. Material and Methods:A total of 1300 cases were assessed for acute renal failure (ARF)and 98 established cases of ARF being included in the research. The neonates (0-28 days old) who met the criteria for ARF, i.e., anuria/oliguria plus a serum creatinine level more than 1.5 mg/dl, were included in this research. The patient's relevant medical history, physical examination, and laboratory tests were recorded on a separate proforma after given informed permission for the procedure. Each patient's outcome was precisely documented. The statistical software for social sciences was used to examine the data (SPSS20.0). A p-value of less than < 0.05 was considered significant. Results:A total of 98 cases (7.5 percent) were studied, with 68 (69.4 percent) males and 30 (30.6 percent) females. The ratio of males to females was 1.6:1. According to the study results, the mean age was 9.85± 7.20 days and the mean weight was 2.54± 0.65 kg. The majority of the infants were delivered at a hospital (73.5 percent). The most prevalent ARF symptoms in our neonates were birth asphyxia (30.6%), sepsis (24.5%), respiratory distress syndrome (RDS) (11.2%), and dehydration (9.2%), bleeding in (4.1 percent) and meconium aspiration in 3(3.1 percent). CCF and neurogenic bladder were both present in two patients. In 4 individuals, obstructive uropathy was found, including 2 cases of urethral valve (PUV) blockage and 2 cases of pelvic ureteric junction obstruction (PUJO). Neonates with ARF had a 28.5 percent overall death rate (28 cases). Conclusion:When it comes to neonates in critical care, acute renal failure is a frequent concern to observe. More than one predisposing factor for acute renal failure was present in the majority of the patients. Preventing acute renal failure in infants may be accomplished by early identification of risk factors and prompt treatment of underlying diseases. Keywords:Renal failure, Sepsis, Birth asphyxia, Neonates
Impact of Covid-19 on the Academic Achievement of Students of District Faisalabad
Authors: Habiba Umm E , Naz Madiha , Hammad Raza Muhammad , Batool Farwa , Ahmad Gillani Syed Muhammad , Shaheen Sumera
Published: June 2022

Background: The education of college level badly affected by the Covid-19 because of several reasons. The educational activities of college level are neglected and the education system is becoming unsatisfactory during the deteriorated era of Covid-19. Objectives: The aim of study is to identify the impact of Covid-19 on the academic achievement of student of district Faisalabad. Methodology: Total population will be 267 students of graduation 4th year in the colleges of (Government College for women Karkhana bazar Faisalabad 101, Government Degree College Samanabad 77 and Government postgraduate Islamiya College for women Eidgah road Faisalabad 89). The sample size of this study was 134 (Government college for women karkhana bazar Faisalabad 54, Government degree college Samanabad 38 and Government postgraduate Islamiya college for women Eidgah road Faisalabad 42) by the confidence interval 6% and confidence level 95%.The sample size had been determined by using online available software i.e; www.surveysystem.com. Respondents were selected for research by simple random sampling technique. The data were collected through questionnaire keeping in view the objectives of the study. Collected data were analyzed by using Statistical Package for Social Sciences (SPSS). The respondents of the present study were asked to give their opinion on a five Likert scale. The percentage, mean, standard deviation and rank order were calculated for presents the results. Conclusion: The study was concluded that students were faced numerous social problems due to the spreading of Covid-19 in all over the world. These social problems directly affected the educational system of every country. On the basis of results, it was concluded that the Covid-19 completely deteriorated the educational system and academic achievements of students. So it becomes crucial to reconstruct every fiber of educational society so that development of student’s academic achievement can be enhanced. Keywords. Covid-19, Educational Activities, Academic Achievements
Investigation of the Effect of Using Surgical Face Masks on Aerobic and Anaerobic Performance of Children During Educational Games
Authors: Ökmen Mehmet Şerif , Köroğlu Yaşar , Sarikaya Mehmet
Published: June 2022

Aim: This study aimed to examine the effect of participating in educational game activities with and without a surgical face mask on the aerobic and anaerobic performance levels of children aged 12-13. Methods: Two male groups, unmasked (n=22) and masked (n=22), participated in the study. Pre-test post-test experimental model was used in the study. The aerobic performances of the groups were determined by the 20m shuttle test, and the anaerobic performances of the groups were determined by the vertical jump test. After the pretest scores of the groups were taken, educational game activities were applied to both groups three days a week for eight weeks. At the end of the eighth week, post-test scores were obtained. These data were presented as arithmetic mean and standard deviation. Independent sample t test was used to compare independent groups and paired sample t test was used to compare dependent groups. Results: Significance level was set as p<0.05. When the pretest and posttest values of age, height and body weight of the groups were compared between the groups, no significant difference was observed (p<0.005). However, when looked at the in-group scores, it was observed that there was a significant difference in the body weight values of the masked group (p˂0.001). In addition, there was a significant difference between the pretest and posttest aerobic performance (MaxVO2) scores of both groups within the group comparison (p˂0.001), but no significant difference was found in the groups’ anaerobic performance scores (p<0.005). However, there was no significant difference between the pretest scores between the groups, while a significant difference was observed between the post-test aerobic (p˂0.001) and anaerobic (p<0.005) scores. Conclusion: As a result, children's participation in regular educational games activities both with and without masks contributes positively to their aerobic performance and it can be said that the aerobic (16.69%) and anaerobic (1.01%) performance scores percentages of the masked group improved more than the unmasked group. Keywords: COVID-19, Surgical Face Mask, Aerobic, Anaerobic, Educational Game.
Comparison of Depression in Women with Primary and Secondary Infertility in Patients at OB/GYN OPD at Sharif Medical City, Lahore, Pakistan
Authors: Khan Junaid , Iftikhar Muhammad Sohaib , Noor Ushna , Sulaiman Reem , Qadeer Tahira , Iftikhar Muhammad Abdullah
Published: June 2022

Objective: To compare the prevalence of depression in women with primary and secondary infertility presenting at Gynecology Outpatient Department at Sharif Medical City, Lahore, Pakistan. Methodology: This is a questionnaire based cross sectional study with a sample size of 138 male and female patients. This study was conducted in (OB/GYN OPD) in a tertiary care setting of Sharif Medical City, Lahore. Duration of the study was 1 month i.e. July 2021. Results: 74% of the patients suffered from infertility due to primary causes, while 26% had secondary infertility. Female infertility accounted for about 93% of infertility cases seen at the clinic while male factor infertility was only 7%. Symptoms of depression were more likely to be seen in women with primary infertility than those with secondary infertility. Conclusions: Despite infertility affecting both men and women, infertility in men is more likely to be under reported. In our study, women with primary infertility often experienced signs and symptoms of depression as compared to women with secondary infertility. In general, infertile women are more likely to be target of abuse, societal pressures, and expectations. Having a good support system can help alleviate most of these symptoms. More research needs to be done to establish a causal relationship between infertility and depression.
Molecular docking, synthesis and biological evaluation of some Imidazo-thiadiazole based Chalcone derivatives as potent triple mutant T790M/C797S EGFR inhibitors
Authors: Alman Abhinandan A. , Soni Vishal , Killedar Suresh G.
Published: June 2022

In present study, we have designed and developed some imidazo-thiadiazole based chalcone derivatives as potential EGFR inhibitors. The designed derivative were screened through molecular docking studies and subjected for synthesis followed by in vitro anticancer activity. Most interestingly many molecules had formed one Pi-donor hydrogen bond (Pi-sulfur) or conventional hydrogen bond with Cys797 which is mutated amino acid residue for the second generation EGFR inhibitors. Many molecules had formed Pi-sulfur bond with Met790 which is mutated amino acid residue and developed resistance to the third generation EGFR inhibitors. All the interaction results presented here suggest these molecule has potential to be developed as most potent 4th generation EGFR inhibitors which will might have effectiveness against triple mutant T790M/C797S EGFR. From this investigation, it was decided to synthesize all the designed molecules with their biological evaluation. In vitro cytotoxicity of synthesized compounds against MCF-7 (Breast cancer) and A549 (Lung cancer) cells were carried out using MTT assay. All the synthesized compounds induced the cytotoxicity to MCF-7 and A549 and displayed good range of IC50 values in between 4 to 59 µm/mL.
Review on nutritional composition, bioactive compounds and therapeutic properties of Hippophae rhamnoides L. (Sea Buckthorn)
Authors: Chauhan Urvashi , Chauhan Ekta Singh
Published: June 2022

Hippophae rhamnoides L. (Sea Buckthorn) is a valuable multifunction plant largely distributed in Europe and Asia. In particular, the berries of sea buckthorn have been widely used as a food source like jam, juices, etc. The berry and seed of this plant are the main sources for its therapeutic and nutritional values. Thus, the plant has been extensively investigated for both of its nutritional and bioactive constituents. In general, the berries of this plant are rich in vitamins (C, E and K); while the ascorbic acid has been reported to be the primary vitamin, contributing to the acidic nature of the berries. Sea buckthorn berries also contain good amount of minerals like calcium and iron. On the other hand, the seed of sea buckthorn offers an excellent source of polyunsaturated fatty acids like palmitic acid, oleic acid and palmitoleic acid. Significant bioactive constituents in sea buckthorn including sitosterol, salicylic acid, tritepenoid, catechin, gallocatechin, epigallocatechin and carotenoids help in combating many diseases like cardiovascular diseases (angina), inflammation, cancer, gastric ulcer and epidermis issues. This review compiled the applications of sea buckthorn including a database of its nutritional and bioactive compounds which ultimately contribute towards the health promoting properties.
Rice grain classification using image processing technique
Authors: Gopalakrishnan K. , Vivek J. Dani Reagan
Published: June 2022

Rice is one of the most widely consumed staple foods, especially in the Asian subcontinent. The quality and varieties of rice grains identification is necessary to avoid mislabeling of rice grain varieties. Mostly it has done by visually. In manual classifications features like Major Axis, Minor Axis, Perimeter, Area, Aspect Ratio, Eccentricity, and Shape Factor are measured by using the specialized tools like calipers and other specialized tools. These features are feed into the machine learning techniques. It is a time consuming process and also there is a chance for measurement errors. In this proposed work the rice images are captured by camera and some preprocessing is done on the image to enhance the image quality. Feature extraction is performed on the collected image using image processing method through MATLAB. The extracted features are given to the Support Vector Machine for classification. The proposed work provides an improved classification accuracy up to 96% with minimum process time.
NOVEL ECOFRIENDLY TECHNIQUE FOR SPECTROPHOTOMETRIC ANALYSIS OF DICLOFENAC SODIUM TABLETS USING MELTED N, N- DIMETHYLUREA AS SOLID SOLVENT
Authors:   C. U. Shah College of Pharmacy, S.N.D.T. Women’s University, Juhu Rd, Santacruz (W), Mumbai - 400 049, India, Dhum Pranali , Nehete Minakshi , Maheshwari Rajesh
Published: June 2022

Commonly used organic solvents for spectrophotometric analysis of water insoluble drugs include alcohol, chloroform, benzene, methylene chloride, dimethyl formamide, acetonitrile, toluene, acetone and hexane. The main drawbacks of organic solvents are high value, toxicity and pollution. Hence, it is essential to replace the organic solvents by other eco-friendly alternative sources. Hydrotropic solubilization technique is the best approach to increase the water solubility of poorly water-soluble drugs and overcome the problems related with organic solvents. The present investigation is an attempt to show application of hydrotropic technique using aqueous solutions of N, N-dimethylurea as a hydrotropic agent for extraction of a poorly water soluble drug, diclofenac sodium, from its tablet formulation. The present research work also provides an ecofriendly method to estimate spectrophotometrically the diclofenac sodium drug in tablet formulations without help of an organic solvent. Proposed spectrophotometric method was found to be novel, accurate, economic, ecofriendly and free from toxicity of organic solvent.
Seminar Penyuluhan Menghilangkan Gerogi Berbicara di Depan Umum kepada Lembaga Amil Zakat Gema Indonesia Sejahtera (LAZGIS) Peduli
Authors: Pertiwi Melisa Winda , Kusmira Mira , Latifah Fitri , Merlina Nita
Published: June 2022

Yayasan LAZGIS merupakan salah satu yayasan yang memiliki siswa didik tingkat SMP dan SMA. Permasalahan mengenai menghilangkan nervous/grogi berbicara didepan umum dialami juga oleh siswa didik di yayasan tersebut. Nervous merupakan musuh utama bagi setiap manusia ketika sedang berbicara di depan umum. Saat kita hendak berbicara di depan umum seringkali kita merasakan grogi sehingga membuat kita tidak nyaman dan terganggu konsentrasinya. Hal tersebut tentu memacu performa kita ketika berada di hadapan publik. Orang tentu akan dapat menilai cara kita berbicara di depan umum. Dengan demikian, seringkali kita merasa tidak percaya diri karena public speaking kita berada dalam nilai yang tidak memuaskan dihadapan public. Yayasan lazgis bekerja bekerjasama dengan Universitas Nusa Mandiri mengadakan Seminar menghilangakn nervous/grogi berbicara didepan umum. Tujuan seminar ini sebagai pemahaman dan memberikan trik kepada siswa siswi supaya tidak lagi nervous ketika berbicara di depan umum. Metode yang digunakan yakni penyampaian materi, kesimpulan serta sesi tanya jawab. Hasil dari penggunaan metode tersebut, peserta mendapatkan informasi teknologi tepat guna yakni tips bagaimana menghilangkan gerogi saat berbicara didepan umum.
Germas Pensi sebagai Metode Intervensi dalam Upaya Pengendalian Kejadian Hipertensi di RT 003 RW 001 Kelurahan Guntung Paikat Kecamatan Banjarbaru Selatan Kota Banjarbaru
Authors: Marlinae Leni , Hibbatullah Muhammad Naufal , Fitriani Erma , Safitri Mulyana , Hakiki Noor
Published: June 2022

Hipertensi menjadi masalah kesehatan yang perlu mendapat perhatian, berdasarkan data WHO. DiIndonesia, hipertensi salah satu penyebab utama kematian dan kesakitan. Berdasarkan data Riskesdas 2018, hipertensi mengalami peningkatan jumlah penderita. Hipertensi meningkat dari 25,8% menjadi 34,1% dari populasi di Indonesia. Provinsi Kalimantan Selatan menduduki peringkat pertama dengan prevalensi hipertensi sebesar 44,1%, lebih tinggi dibandingkan dengan rata-rata prevalensi nasional sebesar 34,1%. Tujuan penelitian untuk melakukan intervensi terkait kejadian hipertensi di Desa Guntung Paikat dengan kegiatan GERMAS PENSI (Gerakan Masyarakat Hidup Sehat: Penyuluhan, konseling dan Senam Hipertensi) dilaksanakan pada November 2021. Sasarannya warga Desa Guntung Paikat RT 003/RW 001 Kecamatan Banjarbaru Selatan Kota Banjarbaru. Jumlah responden sebanyak 18 responden. Program ini diselenggarakan sebagai intervensi dari kejadian hipertensi di RT 003/RW 001 untuk mengubah pengetahuan, sikap dan perilaku masyarakat terhadap upaya pencegahan risiko hipertensi, upaya deteksi dini, dan mendorong masyarakat untuk melakukan olahraga hipertensi. Kegiatan yang dilakukan berupa penyuluhan, pre-post test, pemeriksaan tekanan darah, dan olahraga. Berdasarkan hasil survei diketahui dari 18 responden sebelum intervensi terdapat 11 yang hipertensi, 7 tidak hipertensi. Setelah dilakukan intervensi terjadi penurunan jumlah responden yang mengalami hipertensi yaitu 5 dan 13 tidak hipertensi. Dikarenakan sebagian responden mengalami peningkatan pengetahuan, rutin penyuluhan dan olahraga dalam upaya pencegahannya.
Pendampingan Produksi Mie Sayuran Kekinian sebagai Upaya Meningkatkan Penghasilan UMKM Makanan di Karanganyar Jawa Tengah
Authors: Susilowati Endang , Masykuri Mohammad , Ulfa Maria
Published: June 2022

Usaha Mikro, Kecil, dan Menengah (UMKM) berpotensi untuk dikembangkan di masa pandemi karena kemampuan menyerap tenaga kerja dan menggunakan sumberdaya lokal, serta usahanya relatif bersifat fleksibel. Salah satu usaha kecil yang menarik untuk dikembangkan adalah usaha mie yang telah menjadi komuditas yang digemari masyarakat. Adapun jenis mie yang potensial untuk dikembangkan pada UMKM berbasis makanan adalah mie sayuran. Berdasarkan observasi di UMKM mie kekinian dengan merk “Nyelekitz” yang dikelola oleh Ibu Yuli di Kabupaten Karanganyar Jawa Tengah, ada masalah utama yang perlu diselesaikan. Masalah utama yang dihadapi adalah mie dan bumbunya masih dibeli dari tengkulak dan hanya 1 varian mie saja. Oleh karena itu tim pengabdian UNS melakukan pelatihan dan pendampingan produksi mie dengan varian aneka mie sayuran kekinian. Adapun metode yang dilakukan oleh tim pengabdian adalah melalui pelatihan dan pendampingan kepada mitra pada pembuatan mie sayuran dan bumbunya. Setelah mitra mahir membuat mie sayuran dan layak untuk dipasarkan, maka tim pengabdian melakukan pendampingan dalam pengemasan. Dari kegiatan pengabdian yang telah dilakukan diperoleh hasil bahwa mitra telah trampil membuat mie sayuran dan membuat bumbu mie kekinian. Berdasarkan uji organoleptic, produk mie yang dihasilkan disukai dan sudah layak dipasarkan. Pemasaran produk mie dilakukan di kedai rumah dan online melalui WA grup. Dengan kegiatan pengabdian ini mitra merasa sangat terbantu dan telah meningkatkan omset penjualan dan pendapatan hasil usaha mie kekinian.
Pengelolaan Limbah Nanas Tangkit Menjadi Eco-enzyme di Desa Tangkit Baru Muaro Jambi
Authors: Aini Fitratul , Maritsa Hasnaul , Irvan Ashif , Sazali Ahmad , Wulandari Tia
Published: June 2022

Desa Tangkit Baru merupakan sentra produksi nanas terbesar di Jambi dan dijuluki dengan Desa emas sejuta nanas. Penduduk di desa ini banyak membuka home industri (UMKM) yang memanfaatkan bahan baku nanas menjadi berbagai inovasi olahan nanas, seperti dodol, selai dan manisan dengan sekali produksi menghabiskan 500-1000 buah nanas yang limbahnya dibuang ke lingkungan. Kegiatan Pengabdian kepada masyarakat ini bertujuan mengolah limbah nanas yang tidak termanfaatkan menjadi produk Eco-enzyme yang benilai jual. Pengabdian ini dilakukan melalui tiga tahap, yaitu tahap observasi dan perencanaan, tahap implementasi kegiatan, serta tahap evaluasi. Kelompok sasaran dari kegiatan ini adalah kelompok UMKM dari CV Tulimario dan CV Yusra di desa Tangkit Baru. Hasil dari kegiatan ini adalah edukasi warga dalam m engoptimalkan pengelolaan limbah nanasmenjadi produk yang benilai tinggi sepertiEco-enzyme. Dengan kegiatan PKM yang telah dilakukan ini, kelompok UMKM di Desa Tangkit Baru dapat memanfaatkan limbah dari kulit nanas sebagai bioproduk inovasi dalam mengembangkan produk industri lokal khususnya agroindustri nanas secara berkelanjutan.
Sosialisasi Nyeri Pinggang dan Perubahan Struktur Tulang Belakang Akibat Terlalu Lama Duduk dengan Posisi yang Salah pada Mahasiswa UIN Jakarta
Authors: Solehatin Noviana , Putri Arneta Amelia , Diana Putri , Setiowati Dwi
Published: June 2022

Kurangnya kesadaran akan pentingnya mempertahankan posisi duduk yang tepat, membuat mereka tidak menyadari bahaya yang akan ditimbulkan jika duduk dengan durasi yang lama dipertahankan dengan posisi duduk yang salah. Bukan tak mungkin posisi duduk yang salah tak hanya menyebabkan nyeri pinggang, tetapi juga dapat membuat struktur tulang belakang menjadi tidak normal. Kegiatan pengabdian ini dilakukan dengan pendekatan deskriptif melalui sosialisasi kepada mahasiswa UIN Syarif Hidayatullah Jakarta. Sosialisasi tersebut dilakukan secara daring dengan menggunakan aplikasi Zoom. Pada saat sosialisasi, diketahui bahwa durasi perkuliahan mahasiswa melebihi 2 jam. Tak hanya itu, para peserta juga mengatakan bahwa postur tubuh yang mereka terapkan saat duduk pun dilakukan dengan membungkuk. Walaupun sosialisasi ini dilaksanakan secara daring, tetapi antusiasme para peserta dapat dirasakan dengan kehadiran mereka yang tepat waktu serta terdapat pertanyaan yang diajukan oleh para peserta yang menandakan besarnya keingintahuan mereka terkait materi yang telah disampaikan.
Editoriale
Authors: Cantarella Eva , Maffi Alberto
Published: June 2022

Editoriale a cura di Eva Cantarella e Alberto Maffi
Effect of chemical and biofertilizers on the production of quality seedlings of Acacia Catechu Willd. in root trainers
Authors: Brahmi M. , Dogra A. , Luna R. , Kaushal P. , Sehgal R.
Published: June 2022

An experiment was conducted in root trainers using chemical and biofertilizers in different combinations. The experiment was laid out in RBD (Randomized Block Design) with seven treatments and four replications. The results indicated that out of seven treatments T5 (N17.5P33.0 mg/Root Trainer + Rhizobium + VAM) demonstrated a significant difference in the mean values of morphological and quality parameters of Acacia catechu seedlings. The study revealed that chemical fertilizer can be used in combination with biofertilizers resulted in the good quality seedlings. Biofertilizers alone were not found to be effective.
Mineralogy and trace element studies in the soils of Mussoorie Forest Division, Uttarakhand
Authors: Raina A. , Hussain Hishmi
Published: June 2022

An attempt has been made to study the mineralogy and distribution pattern and concentration trends of trace element in the soil clay fractions and parent material of Maldeota, Satengal and Dhanaulti in Mussoorie forest division, Uttarakhand. Light minerals constituted bulk of sand fractions and comprised quartz, feldspar and mica in order of their abundance. Heavy minerals contributed small fractions and were dominated by opaque minerals, calcite, chlorite, zircon, hornblende etc. Clay fractions are characterized by illite as the dominant clay mineral associated with appreciable amount of kaolinite, mixed layer minerals, chlorite and small amounts of vermiculite, calcite and quartz. Chemical analysis of clay fractions indicates that the soils developed over quartzite, black shale, phosphorite and phyllite, do not show marked variation in silica-sesquioxides as well as silica-alumina ratios within the profiles, whereas in the profiles developed over dolomite and limestone, impoverishment of the sesquioxides in the upper horizons was noticed. This has resulted in the increase in the content of silica in the clay complex of the latter soils as also an increase in silica-sesquioxides ratio at the surface. Trace element studies of rocks and clay fractions show significant correlation between the trace elements (Viz. V, Cr, Co, Ni, Zn, Bo etc.) available in rocks and corresponding clay fractions.
Determining the disease outcome by cytokine storm during infectious diseases and targeting cytokines during Sepsis: Possible therapeutic options
Authors: Amin Tasbir , Hossain Amana , Zahed Fahd
Published: June 2022

The term ‘Sepsis’ can be referred to as the dysfunction of organ(s) because of dysregulated and uncontrolled response of the host to that particular infection. As per statistics, more than 15 million sepsis cases have been recorded every year with around a 20% mortality rate. So, it is needless to mention the major threat this cytokine storm-induced syndrome is posing to public health throughout the world as both infectious and noninfectious diseases are involved with cytokine storm. A lot of evidence can be found on the major pathophysiological impact of cytokines during an infection, but no specific or effective treatment is available to target any inflammation effectively in sepsis. Researches have pointed out that it is possible to reduce the rate of mortality in severe sepsis by administering a low dosage of corticosteroids but unfortunately, no clinical benefits have been recorded during a large-scale clinical trial. But it is proven in a meta-analysis that anti-TNF treatment had been able to demonstrate a major reduction in the mortality rate of sepsis. The review would highlight some of the therapeutic interventions currently available to treat sepsis to get an overview. We would also focus on the association of cytokine storm in inducing sepsis.