bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Plant-Emitted Monoterpenes on Anxiety: A Propensity-Matched Observational Cohort Study
Authors: Donelli Davide , Meneguzzo Francesco , Antonelli Michele , Ardissino Diego , Niccoli Giampaolo , Gronchi Giorgio , Baraldi Rita , Neri Luisa , Zabini Federica
Published: January 2023

Immersive experiences in green areas and particularly in forests have long been known to produce beneficial effects for human health. However, the exact determinants and mechanisms leading to healthy outcomes remain to be elucidated. The purpose of this study was to investigate whether inhaling plant-emitted biogenic volatile compounds, namely monoterpenes (MTs), can produce specific effects on anxiety. Data from 505 subjects participating in 39 structured forest therapy sessions in different Italian sites, were collected. Monoterpenes air concentration was measured at each site. STAI State questionnaires were administered before and after the sessions as a measure of anxiety. A propensity score matching analysis was then performed, considering an above-average exposure to inhalable air MTs as the treatment: the estimated effect was -1.28 STAI-S points (95% C.I. -2.51 to -0.06, p = 0.04), indicating that the average effect of exposure to high MT air concentrations during forest therapy sessions is to decrease anxiety.
Bright Morning Light Enhances Parasympathetic Activity at Night: A Pilot Study of Older People with Dementia, without a Pacemaker
Authors: Liu Chuen-Ru , Kuo Terry B. J. , Jou Jwo-Huei , Lai Chun-Ting Lai , Chang Yu-Kai , Liou Yiing Mei
Published: January 2023

Bright morning light (BML) entrains the body clock, modulates circadian rhythm, and improves sleep-wake disturbances. However, its impact on the autonomic nervous system (ANS) at night remains unclear. Hence, we investigated the effects of BML exposure on activities of the parasympathetic nervous system (PSNS) and sympathetic nervous system (SNS) at night. This non-randomized controlled pilot study included participants ≥60 years, diagnosed with a type of dementia or cognitive disorder. We excluded participants with pacemakers. The treatment group received 2500 lx BML, whereas the control group received approximately 200 lx of general lighting. We measured the heart rate variability to quantify ANS activity. The treatment group displayed significantly increased high-frequency (HF) power (Roy's largest root=2.44; P<.01) and insignificantly decreased normalized low-frequency (LF%) power. The corresponding low-frequency/high-frequency ratio (LF/HF), insignificant decrease, and cognitive function were correlated with PSNS activity (Roy's largest root=3.92; P<.01), which is effective for moderate dementia. BML exposure reduced SNS activity and enhanced PSNS activity at night, which consequently affected cognitive function. Furthermore, the light washout intervention markedly increased SNS activity at night. BML therapy may be a useful clinical tool for alleviating the deterioration of cognitive function.
NEDD9 Overexpression Causes Hyperproliferation of Luminal Cells and Cooperates with HER2 Oncogene in Tumor Initiation: A Novel Prognostic Marker in Breast Cancer
Authors: Purazo Marc L. , Ice Ryan J. , Shimpi Rahul , Hoenerhoff Mark , Pugacheva Elena N.
Published: January 2023

The HER2 overexpression occurs in 10–20% of breast cancer patients. HER2+ tumors are characterized by increase in Ki67, early relapse and increased metastasis. There is little known about factors influencing early stages of HER2- tumorigenesis and diagnostic markers. Previously, it was shown that deletion of NEDD9 in mouse models of HER2 cancer interferes with tumor growth, but the role of NEDD9 upregulation is currently unexplored. We report that NEDD9 is overexpressed in a significant subset of HER2+ breast cancers and correlates with limited response to anti-HER2 therapy. To investigate the mechanisms through which NEDD9 influences HER2-dependent tumorigenesis, we generated MMTV-Cre-NEDD9 transgenic mice. The analysis of mammary glands shows extensive ductal epithelium hyperplasia, increased branching, and terminal end bud expansion. The addition of oncogene Erbb2 (neu) leads to development of early hyperplastic benign lesions earlier (~16 weeks) with a significantly shorter latency than the control mice. Similarly, NEDD9 upregulation in MCF10A-derived acini leads to hyperplasia like DCIS. This phenotype is associated with activation of ERK1/2 and AURKA kinases leading to an increased proliferation of luminal cells. These findings indicate that NEDD9 is setting permissive conditions for HER2-induced tumorigenesis, thus identifying this protein as a potential diagnostic marker for early detection.
Fatty Acid Vesicles as Hard UV-C Shields for Early Life
Authors: Lechuga Iván , Michaelian Karo
Published: January 2023

Theories on life’s origin generally acknowledge the advantage of a semi-permeable vesicle (protocell) for enhancing the chemical reaction-diffusion processes involved in abiogenesis. However, more and more evidence indicates that the origin of life concerned the photo-chemical dissipative structuring of the fundamental molecules under UV-C light. In this paper, we analyze the Mie UV scattering properties of such a vesicle made from long chain fatty acids. We find that the vesicle could have provided early life with a shield from the faint, but dangerous, hard UV-C ionizing light (180-210 nm) that probably bathed Earth’s surface from before the origin of life and until perhaps 1,500 million years after, until the formation of a protective ozone layer as a result of the evolution of oxygenic photosynthesis.
Measuring Bereavement Prevalence in a Complex Sampling Survey: The 2019 Georgia Behavioral Risk Factor Surveillance System (BRFSS).
Authors: Li Changle , Miles Toni P. , Shen Ye , Bayakly Rana , Ido Moses , Khan M. Mahmud
Published: January 2023

The BRFSS is an annual survey conducted by each state and designed to identify trends in a representative sample of the resident population. In its 2019 field survey, the U.S. state of Georgia tested a new 3 – item module to measure the numbers of bereaved, resident adults. Bereavement means that participants answered, ‘Yes’ to the item ‘Have you experi-enced the death of a family member or close friend in the years 2018 or 2019?’. This analysis addresses two questions. Can estimates for bereavement prevalence be derived without large sampling errors, low precision, and small subsamples? Can multiple imputation techniques be applied to overcome non-response and missing data to support multivari-ate modeling? Analyses in this study were conducted under two scenarios. Scenario 1 ap-plies the complex sample weights created by the Centers for Disease Control and imputes values for missing responses. Scenario 2 treats the data as a panel – no weighting com-bined with removal of persons with missing data. Scenario 1 reflects the use of BRFSS data for public health and policy, while Scenario 2 reflects data as it is commonly used in so-cial science research. The bereavement item has a response rate (RR) of 70.8% (5206 of 7534 persons). Subgroups have RR of 55% or more. Under Scenario 1, the prevalence of bereavement is 45.38%, meaning that 3,739,120 adults reported bereaved in 2018 or 2019. The prevalence is 46.02% with Scenario 2 which removes persons with any missing data (4,289 persons). Scenario 2 overestimates the bereavement prevalence by 1.39%. An il-lustrative logistic model is included to show the performance of exposure to bereavement under each scenario. Recent bereavement can be ascertained in a surveillance survey without biases in response. This survey is limited to one US state in a single year and ex-cludes persons aged 17 years and younger.
Edeepsadpr: An Extensive Deep-Learning Architecture for Prediction of the in Situ Crosstalks of Serine Phosphorylation and ADP-Ribosylation
Authors: Jiang Haoqiang , Shang Shipeng , Sha Yutong , Li Lei
Published: January 2023

Protein phosphorylation and ADP-ribosylation (ADPr), as two types of post-translational modifications (PTM), are the process of adding phosphate group and ADP-ribose moieties to proteins, respectively. Although both PTM types can occur on many amino acid types, serine is the most common. Serine phosphorylation (pS), serine ADPr (SADPr), and their in situ crosstalks (pSADPr) play essential roles in biological processes. Although in silico classifiers have been developed for predicting pS and SADPr sites, the classifier for predicting pSADPr sites is unavailable. In this study, we developed classifiers to predict pSADPr sites. Specifically, we collected 3250 human pSADPr, 7520 SADPr, 151,227 pS and 80,096 unmodified serine sites. Based on them, we investigated the characteristics of pSADPr sites and constructed three classifiers to predict pSADPr sites from the pS dataset, the SADPr dataset and the protein sequences separately. We built and evaluated five deep-learning classifiers in ten-fold cross-validation and independent test datasets. Three of them (e.g. Convolutional Neural Network with the One-Hot encoding, dubbed CNNOH) performed better than the rest two. For instance, CNNOH had the AUC values of 0.700, 0.914 and 0.954 for recognizing pSADPr sites from the SADPr, pS and unmodified serine sites.Therefore, it is challenging to distinguish pSADPr sites from SADPr sites compared to the other two. It is consistent with our observation that pSADPr's characteristics are more similar to those of SADPr than the rest. Furthermore, we used the classifiers as base classifiers to develop a few stacking-based ensemble classifiers to improve performance. However, none of the ensemble classifiers showed better performances, suggesting that the base classifiers have good enough performances. Finally, we developed an online tool for extensively predicting human pSADPr sites based on the CNNOH classifier, dubbed EdeepSADPr. It is freely available through http://edeepsadpr.bioinfogo.org/.
Quality Assurance in Higher Education and its Implications on Higher Education Institutions and Challenges in Zambia
Authors: Bwalya Tuesday
Published: January 2023

This paper discussed the concept of quality assurance (QA) in higher education and its implications to higher education institutions (HEIs) and the possible challenges. The study evaluated literature concerning QA in Zambia and elsewhere. The findings of the study show that QA is implemented through external and internal mechanisms such as accreditation, registration, institutional auditing, and the use of external examiners, self-evaluation, and peer reviews. The QA implications to HEIs in Zambia are that there is a need for accreditation of academic programmes with the Higher Education Authority (HEA) by HEIs. Further, HEIs should establish QA units to spearhead quality issues, reactive, and introduce the use of external examiners to ensure quality. The challenges identified in the implementation of QA in HEIs include inadequate funding, infrastructure, shortage of qualified academic staff, and lack of standalone QA units in some HEIs. In this regard, it has been recommended among other things, government improve funding in public HEIs, construct infrastructure, HEIs establish QA units, and recruit and retain qualified academic staff to ensure the quality of education.
Molecular Tracking of The Origin of Vesicular Stomatitis Outbreaks in 2004 and 2018, Ecuador
Authors: Vasco-Julio David , Aguilar Dayana , Maldonado Alexander , De la Torre Euclides , Cisneros-Montufar Maria Soledad , Bastidas-Caldes Carlos , Navarro Juan-Carlos , De Waard Jacobus H.
Published: January 2023

Vesicular stomatitis virus (VSV) is an arbovirus causing vesicular stomatitis (VS) in livestock. There are two serotypes recognized: New Jersey (NJ) and Indiana (IND). The virus can be transmitted directly by contact or by vectors. In Ecuador, in the year 2018, an outbreak of Vesicular Stomatitis (VS) in cattle, caused by VSV-NJ and VSV-IND, was recorded with 399 cases reported distributed over 18 provinces. We determined the phylogenetic relationships among 67 strains. For the construction of phylogenetic trees, the viral phosphoprotein gene was sequenced, and trees were constructed based on the Maximum Likelihood method using 2004 outbreak strains from Ecuador (Genbank) and the 2018 sequences (this article). We built a haplotype network for VSV-NJ to trace the origin of the 2004 and 2018 epizootics through topology and mutations connections. These analyses suggested two different origins, one related with the 2004 outbreak and the other from an enzootic transmission source in 2018. Our analysis also suggests different transmission patterns with several small and independent outbreaks, most probably transmitted by vectors in the Amazon, and in the Andes and Coast region by the movement of livestock. We recommend further research for vectors and vertebrate reservoirs in Ecuador to clarify the mechanisms of the reemergence of the virus.
Natural Language Processing Accurately Categorizes Indications, Findings, and Pathology Reports from Multicenter Colonoscopy
Authors: Vadyala Shashank reddy
Published: January 2023

Colonoscopy is used for colorectal cancer (CRC) screening. Extracting details of the colonoscopy findings from free text in electronic health records (EHRs) can be used to determine patient risk for CRC and colorectal screening strategies. In this study, we developed and evaluated the accuracy of a deep learning model framework to extract information for the clinical decision support system to analyze relevant free-text colonoscopy reports, including indications, pathology, and findings notes. The Bio-Bi-LSTM-CRF framework was developed using Bidirectional Long Short-term Memory (Bi-LSTM) and Conditional Random Fields (CRF) to extract several clinical features from these free-text reports, including indications for the colonoscopy, findings during the colonoscopy, and pathology of the resected material. We then trained the Bio-Bi-LSTM-CRF and existing Bi-LSTM-CRF models on 80% of 4,000 manually annotated notes obtained from the colonoscopy reports of 3,867 patients. The clinical notes were from a group of patients aged over 40 years old enrolled in four Veterans Affairs Medical Centers. A total of 10% of the remaining annotated notes were used to train hyperparameter, while the remaining 10% were used to evaluate the accuracy of our model (Bio-Bi-LSTM-CRF) and to compare the results with the outcomes obtained using Bi-LSTM-CRF. The results of our experiments showed that the bidirectional encoder representations by integrating dictionary function vector from Bio-Bi-LSTM-CRF and strategies character sequence embedding approach is an effective way to identify colonoscopy features from EHR-extracted clinical notes. Therefore, the Bio-Bi-LSTM-CRF model is concluded to be capable of creating new opportunities to identify patients at risk for colon cancer and to study their health outcomes.
Neutrosophic Messy-Style SuperHyperGraphs To Form Neutrosophic SuperHyperStable To Act on Cancer's Neutrosophic Recognitions In Special ViewPoints
Authors: Garrett Henry
Published: January 2023

in this research, new setting is introduced for new SuperHyperNotion, namely, Neutrosophic SuperHyperStable. In this research article, there are some research segments for ``Neutrosophic SuperHyperStable'' about some researches on neutrosophic SuperHyperStable. With researches on the basic properties, the research article starts to make neutrosophic SuperHyperStable theory more understandable. Assume a neutrosophic SuperHyperGraph. Then a ``neutrosophic SuperHyperStable'' $\mathcal{I}_n(NSHG)$ for a neutrosophic SuperHyperGraph $NSHG:(V,E)$ is the maximum neutrosophic cardinality of a neutrosophic SuperHyperSet $S$ of neutrosophic SuperHyperVertices such that there's no neutrosophic SuperHyperVertex to have a neutrosophic SuperHyperEdge in common. A basic familiarity with SuperHyperGraph theory and neutrosophic SuperHyperGraph theory are proposed.
Strongyloide Species Determinants in Vietnamese Human Stool Samples by Molecular Methods
Authors: Vinh Le Duc , Thach Nguyen Kim , Quang Huynh Hong , Do Binh N. , Hanh Tran Thi Duc , Toan Nguyen Minh , Lang Ngo Van , Tuyen Nguyen Trung , Huong Nguyen Thu
Published: January 2023

Background: Strongyloidiasis, a neglected disease caused by intestinal nematodes of the genus Strongyloides, is endemic to tropical and subtropical areas such as Vietnam. The morphological diagnosis of larvae by Hara Mori culture technique and microscopicare are considered the standard diagnostic procedures in the endemic areas of Strongyloides spp. However, they could only identify the genus, not the species of Strongyloides. DNA-molecular techniques which are highly sensitive and more cost-effective have been increasingly utilized in detection of Strongyloides species. This study aims to determine prevalence and the species of Strongyloides among resident population in Duc Hoa district, Long An province, Southern Vietnam. Methods: A cross-sectional study was conducted using 1,190 stool samples collected in Duc Hoa district, Long An province, Vietnam, from July, 2017 to November 2018. The stool specimens were transported to the Laboratory of Medical Parasitology, Pham Ngoc Thach University of Medicine within two hours of collection at an appropriate temperature of 25 oC. All samples were stored at 2 - 8°C and processed within 48 hours for microscopic examination. Molecular detection was carried out at Laboratory of Molecular Biology, Pham Ngoc Thach University of Medicine, Hochiminh city, VietNam. Results: Of the 1,190 samples tested, Strongyloides spp. larvae were detected in 79 specimens (6.6%) by two classical parasitological methods, namely direct microscopy and the modified Harada-Mori filter paper culture. DNA was extracted from 70 of the 79 samples of Strongyloides spp. larvae, which was subsequently characterized by real-time PCR amplification of the 18S and 28S regions of the rDNA gene. The results showed that 97.1% of the DNA samples were S. stercoralis, 2.9% were co-infections with S. ratti and S. stercoralis, and 2.9% belonged to S. ratti. For all 14 isolates, nucleotide sequencing was compared with other human pathogenic species of Strongyloides whose sequences are available in GenBank. The identity of 12/14 sequences were confirmed as S. stercoralis with a high level of similarity (91.3% - 100%) and over 98% for S. ratti. Between the two co-infection samples, the higher similarity belonged to S. stercoralis. Conclusion: A molecular amplification of small subunit ribosome RNA followed by sequence analysis has been proved to be a suitable method for discrimination of Strongyloides spp. retrieved from stool samples.
Physical, Thermal, and Chemical Properties of Fly Ash Cenospheres Obtained for Different Sources
Authors: Shishkin* Andrei , Abramovskis Vitaliijs , Zalite Ilmars , Singh Ashish Kumar , Mezinskis Gundars , Popov Vladimir , Ozolins Jurijs
Published: January 2023

Cenospheres are hollow particles in fly-ash, a by-product of coal burning, and are widely used as reinforcement for developing low density composites called syntactic foams. This study investigates the physical, chemical, and thermal properties of cenospheres obtained from 3 different sources, CS1, CS2, and CS3, for the development of syntactic foams. Description of floatation method to separate broken particles is given, and it was seen that up to 11 % of the particles were damaged. Post heat treatment samples show development of SiO2 phase in the cenosphere, which is not present in the as received product. CS3 had the highest quantity of Si element, compared to the other two, showing the difference in the source quality. The particle size distribution for CS2 is very narrow while for the others is much broader. All censopheres have porous walls but the morphology of CS2 is the most uniform and smooth. For the application of metallic layer and subsequent consolidation via spark plasma sintering, CS2 was deemed the most physically, thermally, and chemically suitable.
Ranitidine Alleviates Anxiety-Like Behaviour and Improves the Density of Pyramidal Neurons upon Deactivation of Microglia in CA3 Region of the Hippocampus in A Cysteamine Hcl-Induced Mouse Model of Gastrointestinal Disorder
Authors: Selvaraj Divya Bharathi , Vergil Andrews Jemi Feiona , Anusuyadevi Muthuswamy , Kandasamy Mahesh
Published: January 2023

Elevated levels of histamine cause the secretion of gastric hydrochloric acid (HCl), leading to gastrointestinal (GI) disorders and anxiety. While aberrant levels of histamine mediate neuroinflammation, pathogenic alterations in the hippocampus of the brain have been linked to anxiety. Eventually, antihistamine drugs that are used against GI disorders appear to be anxiolytic agents. Ranitidine is a widely used antihistamine drug to manage GI disorders as it works by blocking the histamine (H)-2 receptors in oxyntic cells thereby, reducing the HCl production in the stomach. Though some reports indicate the neuroprotective effects of ranitidine, its role against GI disorders related to anxiety remains unclear. Therefore, we investigated the effect of ranitidine against anxiety-related behaviors, neuronal density, and signs of microglia activation in the hippocampal CA3 region of cysteamine HCl-induced mouse model of GI disorder. Results obtained from the open field test (OFT), light and dark box test (LDBT), and elevated plus maze (EPM) revealed that ranitidine treatment reduces anxiety-like behaviors in experimental animals. Nissl staining and immunohistochemical assessment of Iba-1 positive microglia in the cryosectioned brains revealed that the ranitidine treatment enhances the density of pyramidal neurons in association with reduced activation of microglia in the CA3 region of the hippocampus of experimental mice.
Trend Research of Diabetes and Pyroptosis: Bibliometric Analysis and Literature Review
Authors: Xiaodong Li , Xiaojuan Su , Mingchao Xu
Published: January 2023

Objective: To visualize and analyze the published literature on diabetes and pyroptosis based on a bibliometric approach, so as to provide a comprehensive picture of the hot research directions and dynamic progress in this field. Methods: This study was based on the web of science core collection database to conduct a comprehensive search of the published literature in the field of diabetes and Pyroptosis from January 1985 to August 2022, including the published research literature in this field, as well as a visual analysis of the number of citations, year of publication, journal, author, research institution, country, and research topic. Results: A total of 139 literature on research related to diabetes and cellular scorch from 2011 to 2022 were retrieved, with a total of 3009 citations and a maximum of 255 citations for a single article, which had a first authorSchmid-Burgk, JL The first author of this article is from Germany; among 20 publishing countries, China leads with 100 articles; among 222 publishing institutions, Harbin Medical University leads with 18 articles and 184 citations; among 980 authors, Chen, X from China tops the list of high-impact authors with 5 articles and 29 citations; Among the 98 journals, "CELL DEATH DISEASE" ranked first in both volume and high impact journals with 4 articles and 29 citations; among 349 keywords, "pyroptosis" ranked first with a cumulative frequency of 65 times. The cluster analysis was divided into three categories, chronic complications of diabetes and pyroptosis (67 articles), diabetes and pyroptosis (60 articles), and diabetes combined with other diseases and pyroptosis (12 articles), and the number of articles related to diabetes and its chronic complications increased rapidly from 2019, among which, diabetic cardiomyopathy (27 articles) had the highest number of articles. Conclusions: Based on a comprehensive analysis of published literature in the field of diabetes and pyroptosis from 2011-2022, this study achieved a visual analysis of studies with significant and outstanding contributions to the field, thus framing a picture showing the development and changes in the field. At the same time, this study provides research information and direction for clinicians and investigators to conduct diabetes and pyroptosis related research in the future.
Growth Developmental Defects of Mitochondrial Iron Transporter 1 and 2 Mutants in Arabidopsis in Iron Sufficient Conditions
Authors: Vargas Joaquin , Gómez Isabel , Vidal Elena , Lee Chun Pong , Millar A. Harvey , Jordana Xavier , Roschzttardtz Hannetz
Published: January 2023

Iron is the most abundant micronutrient in plant mitochondria and it has a crucial role in biochemical reactions involving electron transfer. It has been described in Oryza sativa that Mitochondrial Iron Transporter (MIT) is an essential gene and that knockdown mutant rice plants have a decreased amount of iron in mitochondria, strongly suggesting that OsMIT is involved in mitochondrial iron uptake. In Arabidopsis thaliana, two genes encode MIT homologues. In this study, we analyzed different AtMIT1 and AtMIT2 mutant alleles, confirming that individually AtMIT1 nor AtMIT2 genes are essential. When we generated crosses between Atmit1 and Atmit2 alleles we were able to isolate homozygous double mutant plants. Interestingly, homozygous double mutant plants were obtained only when mutant alleles of Atmit2 with the T-DNA insertion in the intron region were used for crossings, and in these cases a correctly spliced AtMIT2 mRNA was generated, although at a low level. Atmit1 Atmit2 double homozygous mutant plants, which were knockout for AtMIT1 and knockdown for AtMIT2, were grown and chacterised in iron sufficient conditions. Pleiotropic developmental defects were observed including abnormal seeds, increased number of cotyledons, slow growth rate, pinoid stems, defects in flower structures and reduced seed set. We observed a possible phenomenon of T-DNA suppression in the next generation of Atmit1 Atmit2 double homozygous mutant plants, correlating with an increased splicing of the AtMIT2 intron containing the T-DNA. Molecular analysis of gene expression markers for mitochondrial and oxidative stress showed that Atmit1 Atmit2 double homozygous mutant plants express a degree of mitochondrial perturbation. A RNA-Seq study was performed and we could identify more than 760 genes differentially expressed in Atmit1 Atmit2, including genes involved in iron transport, coumarin metabolism, and hormones metabolism, transport and signaling. Our data suggest that some of the phenotypes observed in Atmit1 Atmit2 double homozygous mutant plants are mediated by defects in auxin homeostasis.
Psychosocial Well-Being and Adaptation in Children and Adolescents with Asperger's Syndrome during Covid-19 Pandemic
Authors: Tremolada Marta , Rosa Mariaangela , Incardona Roberta Maria , Taverna Livia , Guidi Michele
Published: January 2023

Mental health could worsen in children and adolescents with autism spectrum disorder during the Covid19 pandemic. In addition, their parents could be more at risk for an increase in anxiety and depression symptomatology. This study aims to understand the adaptation and the psychosocial well-being in a sample of 16 males aged 10-21 years old with Asperger syndrome after the quarantine for Covid19 when they return to school and partially to their activities in September 2020, The approach adopted is multi-informant with a battery of questionnaires on psychological health and adaptation given by a secure online web data Qualtrics both to adolescents and also to their parents. Paralleling matched peers with typically development were assessed adopting the same methodology. The results evidenced several difficulties in Asperger’s psychological health, especially in anxiety and socialization. Also adaptation is put in crisis, even if they reported a good comprehension and adoption of the behaviors anti-Covid19. Parents of children with Asperger reported similar psychological difficulties and general health than those of the group of children typically developing. Some clinical indications could be discussed for psychologists who follow children and adolescents with Asperger.
Development of Budgetary Slack Research in Indonesia
Authors:   Universitas Jenderal Soedirman, Nisa Rizka Fauziyatun , Rokhayati Hijroh ,   Universitas Jenderal Soedirman
Published: January 2023

This study aimed to provide an overview of the development of budgetary slack research in Indonesia. The research method was charting the field developed by Hesford et al. (2007). In this study, articles were classified based on topics, research methods, samples, and theories. The research samples were 161 articles published in 35 journals accredited by Sinta 1, 2, and 3 with 23 years of observation from 1999-2021. The results showed that for the research topic, the budget participation variable was the most widely used antecedent in research. Then as many as 157 articles used quantitative research methods, the most widely used samples were Local government work unit (SKPD) budget makers, and the most widely used theory in budgetary slack research was agency theory. Suggestions for further budgetary slack research are to use an experimental research design with research participants from professional accountants, managers, or employees who are directly involved in the budgeting process. In addition, it can examine several internal influence variables (moral reasoning, locus of control, religiosity, honesty, ethics, managerial trust, and motivation) and external influence variables (compensation scheme (clawback) and compliance pressure).
Pre-Visit Digital Messaging Improves Patient-Reported Outcome Measure Participation Prior to the Orthopaedic Ambulatory Visit
Authors: Yedulla Nikhil R. , Hester Joshua D. , Patel Mit M. , Cross Austin G. , Peterson Edward L. , Makhni Eric C.
Published: January 2023

Background:

Patient-reported outcome measures (PROMs) are metrics that assess physical health, mental health, pain, and satisfaction. However, PROM collection in orthopaedic clinics presents numerous logistical and financial challenges. These challenges are reduced when PROMs are completed before clinic encounters, relieving the workflow constraints of in-office PROM collection. The purpose of this study was to determine the efficacy of 3 different methods with respect to pre-visit electronic PROM completion.

Methods:

Consecutive adult orthopaedic patients with no previous PROM participation were enrolled. Patients who registered with the electronic medical record (EMR) patient portal (MyChart) and with active e-mail addresses were randomly assigned to 1 of 3 arms: control (no pre-visit messages), MyChart (EMR patient portal pre-visit messages), and e-mail (e-mail pre-visit messages). The primary outcome measure was pre-visit PROM completion rates in orthopaedic patients, and the secondary outcome measures were time to pre-visit PROM form completion and PROM form completion rates according to patient demographic characteristics. By default, the Patient-Reported Outcomes Measurement Information System (PROMIS) forms were available for completion through the portal by 7 days before scheduled visits. Pre-visit messages were sent 7 days prior to the scheduled visit except in the control group, with reminders sent 3 days prior if still not completed. The patients in each arm who completed all assigned forms were labeled as having total PROM completion, and those who completed at least 1 completed form were considered as having partial PROM completion. Multivariable logistic regression models were used to assess differences in PROM completion rates between study arms. Kruskal-Wallis tests were performed to compare the date of the form completion.

Results:

A total of 291 patients were included. The pre-visit total completion rates for assigned PROMs were higher in the MyChart arm (49% of 97 patients; p = 0.005) and the e-mail arm (52% of 100 patients; p = 0.002) in comparison with the control arm (30% of 94 patients). Male patients were more likely than female patients to have partial pre-visit PROM completion (odds ratio [OR], 1.74; p = 0.03), and Caucasian patients were more likely to have partial pre-visit PROM completion than African American patients (OR, 2.28; p = 0.01).

Conclusions:

Orthopaedic patients receiving either e-mail or patient portal messages demonstrated higher pre-visit PROM completion rates. Pre-visit messaging appears to be a useful strategy for increasing PROM completion rates and limiting the clinical workflow strain imposed by in-clinic PROM administration.

Level of Evidence:

Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
Establishment of a Novel Rat Model of Gram-Negative Periprosthetic Joint Infection Using Cementless Hip Hemiarthroplasty
Authors: Ibrahim Mazen M. , Liu Yun , Ure Kerstin , Hall Clayton W. , Mah Thien-Fah , Abdelbary Hesham
Published: January 2023

Background:

Gram-negative periprosthetic joint infections (GN-PJIs) present unique challenges. Our aim was to establish a clinically representative GN-PJI model that recapitulates biofilm formation in vivo. We also hypothesized that biofilm formation on the implant surface would affect its ability to osseointegrate.

Methods:

Three-dimensionally-printed medical-grade titanium hip implants were used to replace the femoral heads of male Sprague-Dawley rats. GN-PJI was induced using 2 bioluminescent Pseudomonas aeruginosa strains: a reference strain (PA14-lux) and a mutant biofilm-defective strain (ΔflgK-lux). Infection was monitored in real time using an in vivo imaging system (IVIS) and magnetic resonance imaging (MRI). Bacterial loads were quantified utilizing the viable colony count. Biofilm formation at the bone-implant interface was visualized using field-emission scanning electron microscopy (FE-SEM). Implant stability, as an outcome, was directly assessed by quantifying osseointegration using microcomputed tomography, and indirectly assessed by identifying gait-pattern changes.

Results:

Bioluminescence detected by the IVIS was focused on the hip region and demonstrated localized infection, with greater ability of PA14-lux to persist in the model compared with the ΔflgK-lux strain, which is defective in biofilm formation. This was corroborated by MRI, as PA14-lux induced relatively larger implant-related abscesses. Biofilm formation at the bone-implant interface induced by PA14-lux was visualized using FE-SEM versus defective-biofilm formation by ΔflgK-lux. Quantitatively, the average viable colony count of the sonicated implants, in colony-forming units/mL, was 3.77 × 108 for PA14-lux versus 3.65 × 103 for ΔflgK-lux, with a 95% confidence interval around the difference of 1.45 × 108 to 6.08 × 108 (p = 0.0025). This difference in the ability to persist in the model was reflected significantly on implant osseointegration, with a mean intersection surface of 4.1 × 106 ± 1.99 × 106 μm2 for PA14-lux versus 6.44 × 106 ± 2.53 × 106 μm2 for ΔflgK-lux and 7.08 × 106 ± 1.55 × 106 μm2 for the noninfected control (p = 0.048).

Conclusions:

To our knowledge, this proposed, novel in vivo biofilm-based model is the most clinically representative for GN-PJI to date, since animals can bear weight on the implant, poor osseointegration was associated with biofilm formation, and localized PJI was assessed by various modalities.

Clinical Relevance:

This model will allow for more reliable testing of novel biofilm-targeting therapeutics.
Youth Empowerment Through Small Medium Micro Business Centers
Authors: Hedar Fitria , Fitria Agustina Isna
Published: January 2023

Sidoarjo Regency is one of the districts that has potential in the field of home industry economics. One of them is located in Kedung Sumur Village, Krembung Subdistrict, Sidoarjo Regency in the form of a hawker village that has been established since 1961. Kedung Sumur Village Government has tried hard to be able to improve the economy of its people through the Kampung Jajanan UMKM program in hopes of being able to build an independent village in terms of its economy and also able to improve the welfare of its people. Thus the Kedung Sumur Village Government tried to deceive the community including its youth to be directly involved in the Kampung Jajanan UMKM  program. The methods used qualitative descriptive data are obtained through observation, documentation, interviews and using the source of books, journals, and policy documents. The results of this study show that youth empowerment in realizing small and medium-sized micro business opportunities in the village of Kedung Sumur Village, Krembung District, Sidoarjo Regency has been running effectively. Seen from the three stages of empowerment that run well, namely the awareness stage in the form of socialization, the stage of ability transformation in the form of training and the stage of improving intellectual ability in the form of product innovation.
The Effect of Fiber Length Variations on the Composite Fiber of Oil Palm Empty Bunches (OPEB) on Tensile Strength
Authors: Cahyanto Reksi Dwi , Mujianto Agus , Binyamin Binyamin , Nugroho Andi
Published: January 2023

Composite is a combination of materials formed from mixing between two or more of the forming materials. This research aims to determine the effect of variations in fiber length with lengths of 4cm, 6cm, and 8cm with a volume fraction of OPEFB fiber of 30% and NaOH alkaline immersion for 2 hours. The tests carried out were tensile testing using ASTM D3039 and bending testing using ASTM D7264. Based on the study's results with the 30% OPEFB fraction with the highest tensile strength yield, the 8cm fiber length of 13,33 MPa was achieved. Meanwhile, the lowest value was achieved with a length of 4cm of 3,2MPa.
Síndrome de burnout y su relación con el desempeño laboral en colaboradores de la empresa Menorca durante periodo pandemia Covid 19 - Lima - 2021
Authors:   , Alba Alvaro Maria Camila
Published: January 2023

El propósito del presente trabajo de investigación ha sido determinar la correlación existente entre el síndrome burnout y desempeño laboral de los colaboradores de la empresa Menorca durante el periodo pandemia covid 19, en Lima 2021. Para la realización del estudio se eligió a una empresa del sector de construcción, que fue afectada por el confinamiento. Se empleó el diseño no experimental, cuantitativo de tipo descriptivo correlacional y con corte transversal. La muestra y población del estudio estuvo conformada por 100 colaboradores, se les aplicó el cuestionario MBI y de Desempeño laboral, la confiabilidad fue medida por el Alfa de Cronbach de las cuales se obtuvo 0.752 en la primera variable y 0.829 en la segunda variable. De esta manera, los resultados del presente estudio lograron evidenciar los siguientes resultados: La correlación es negativa y media, con un Rho de Spearman de -0.243, cuyo grado de significancia fue con un p-valor de 0,012. Por consiguiente, se evidenció la existencia de correlación significativa entre las variables de estudio. Asimismo, se evidenció en cuanto al síndrome burnout, que el 92% de los encuestados consideran que están en riesgo de padecerlo, el 5% sienten la presencia y solo el 3% no lo padecen. Respecto al desempeño laboral, el 87% de los encuestados considera que tienen un nivel bueno, el 13% un nivel regular y no se encontró de nivel bajo. Como conclusión general, se encontró una relación inversa entre el síndrome burnout y desempeño laboral en los colaboradores de la empresa Menorca durante el periodo pandemia covid 19.
Pengaruh Kepemimpinan Islam Terhadap Kinerja Karyawan Melalui Motivasi Kerja Sebagai Variabel Intervening Pada Karyawan BMT Hasanah Ponorogo
Authors: Mukaromah Haniatul
Published: January 2023

This study aims to analyze the influence of Islamic leadership on employee performance through work motivation as an intervening variable at BMT Hasanah Ponorogo. This research was conducted at  BMT Hasanah Ponorogo, and the respondents were employees at the BMT Hasanah Ponorogo. The data type was used as primary data, and the data collection technique used a technical survey with a questionnaire. Analysis of the data in this study using the Submission of a Structural Model (Inner Model) using the SmartPLS analysis tool. Based on the analysis results that have been carried out, the results show that Islamic leadership does not affect employee performance at BMT Hasanah Ponorogo. Islamic leadership positively and significantly affects employee motivation at BMT Hasanah Ponorogo. Motivation positively and significantly affects employee performance at BMT Hasanah Ponorogo. So it can be concluded that to maximize the performance of BMT Hasanah Ponorogo employees, the company must maintain and improve Islamic leadership and work motivation.Penelitian ini bertujuan untuk menganalisis pengaruh kepemimpinan Islam terhadap kinerja karyawan melalui motivasi kerja sebagai variable intervening pada BMT Hasanah Ponorogo. Penelitian ini dilakukan di BMT Hasanah Ponorogo dan yang menjadi responden penelitian ini adalah karyawan BMT Hasanah Ponorogo.  Jenis data yang digunakan adalah data primer dan teknik pengumpulan data menggunakan teknis survey dengan alat bantu kuesioner. Analisis data dalam penelitian ini menggunakan Pengajuan Model Struktural (Inner Model) dengan menggunakan alat analisis SmartPLS. Berdasarkan hasil analisis yang telah dilakukan diperoleh hasil bahwa Kepemimpinan Islam tidak berpengaruh terhadap kinerja karyawan pada BMT Hasanah Ponorogo. Kepemimpinan Islam berpengaruh positif dan signifikan terhadap motivasi karyawan pada BMT Hasanah Ponorogo. Motivasi berpengaruh positif dan signifikan terhadap kinerja karyawan pada BMT Hasanah Ponorogo. Sehingga dapat disimpulkan bahwa untuk lebih memaksimalkan kinerja karyawan BMT Hasanah Ponorogo maka perusahaan harus menjaga dan meningkatkan kepemimpinan Islam dan motivasi kerja.
Fuzzy Decision-Making Method based Evaluation of Smart Healthcare Management
Authors: Quasim Mohammad Tabrez , Shaikh Asadullah , Shuaib Mohammed , Sulaiman Adel , Alam Shadab , Asiri Yousef
Published: January 2023

The smart medical system is becoming a health policy service that employs wearables, online services and mobile devices to connect to the internet continuously and connect patients, technology and healthcare centers, and then cope efficiently and thoughtfully with the demands of medical ecosystems. This article explores some of the issues facing users to speed up using and accepting intelligent medical technology for access to omnipresent healthcare. The article analyses how Fuzzy Decision Making may be integrated to create better health solutions with an intelligent approach. The smart medical care management system enables the patient to use medical services and services in any place and at any time, including emergency preparedness, medication management and monitoring services. An assessment of this method for managing new concepts comparable to direct health services must be examined. Hence, this paper Smart Healthcare Management Evaluation utilizing Fuzzy Decision Making (SHME-FDM) model, has been proposed to evaluate the technological integration performance. The present paper assesses the security of health data privacy in the intelligent medicare system utilizing the Fuzzy Analytical Hierarchy Process- Preference Technique similar to the ideal solution (Fuzzy AHP-TOPSIS). This paper usage the fuzzy neural network for health care prediction. The test analyses the reliability, error rate accuracy of the fuzzy outcomes. The security hazard analysis data demonstrate that the suggested fuzzy model has the highest risk assessment performance in contrast to the current models.
Predicting Lung Cancer Survival Prognosis based on the Conditional Survival Bayesian Network
Authors: lu zhong , Yang Fan , Sun Shanshan , Wang Lijie , Yu Hong , Nie Xiushan , Liu Ailing , Xu Ning , Zhang Lanfang , Zhang Mingjuan , Qi Yue , Ji Huaijun , Liu Guiyuan , Zhao Huan , Jiang Yinan , Li Jingyi , Song Chengcun , Yu Xin , Yang Liu , Yu Jinchao , Feng Hu , Guo Xiaolei , Yang Fujun , Xue Fuzhong
Published: January 2023

Lung cancer is one of the leading causes of cancer death and impose an enormous economic burden on patients. It is important to develop an accurate risk assessment model to determine the appropriate treatment for patients after the initial diagnosis of lung cancer. The Cox proportional hazards model is mostly utilized in survival analysis. However, real-world medical data is always incomplete, which poses a great challenge to the application of the Cox proportional hazards model. The commonly used imputation methods cannot achieve sufficient accuracy in the issue of missing data, which drives us to investigate the novel imputation methods for the development of clinical prediction models. In this article, we present a novel missing data imputation method: Bayesian networks for inferring missing covariates. We collected a total of 5,240 patients diagnosed with lung cancer from Weihai Municipal Hospital, China. Then we applied a joint model that combined a Bayesian network and a Cox model to predict mortality risk in individual patients with lung cancer. The established prognostic model achieved a good predictive performance in discrimination and calibration. Through experiments, we proved that the Bayesian network methodology is a robust and accurate approach to addressing the issue of missing data. We showed that combining the Bayesian network with the Cox proportional hazards model is highly beneficial, providing a more efficient tool for risk prediction.
Effect of Static Stiffness of Soil on Internal Force Distribution of Building Structures Subjected to Earthquake Loads
Authors: mena adisu mesene , Manuka Dagimwork Asele
Published: January 2023

The soil structure interaction model is developed by substructure modeling method. For the purpose of comparative study, the SSI depth is varied by 0m, 1m, 3m, and 5m. To consider this case the foundation soil of firm soil, soil class-A and the soft soil, soil class-C is used to comparative study. By considering rigid foundation, the soil can be replaced by a set of equivalent springs and dashpots in the inertial interaction analysis. The soil structure interaction can be modeled by using equivalent static spring modeling method and static stiffness of spring can be calculated by using the supporting soil properties. To calculate elastic static stiffness of soil the most well-known G. Gazetas equation is used. The static stiffness calculated shows that for the increased depth of soil structure interaction there is increased static stiffness. So, the calculated static stiffness is used as elastic spring constant and it is assigned on the footing column base of building structure which modeled by SAP200 software. Time history analysis is conducted by applying earthquake load on the structure by using SAP200 V 14.
Serum alpha-CGRP levels are increased in COVID-19 patients with headache indicating an activation of the trigeminal system
Authors: Gárate Gabriel , Toriello María , González-Quintanilla Vicente , Pérez-Pereda Sara , Madera Jorge , Pascual Marta , Olmos José Manuel , Pascual Julio
Published: January 2023

Background: Headache is among the most frequent symptoms of acute COVID-19 infection. Its mechanisms remain obscure, but due to its migraine-like characteristics, the activation of the trigeminal system could account for its underlying pathophysiology.
Methods: Our aim was to compare the serum levels of CGRP, as a theoretical marker of trigemino-vascular activation, in 25 COVID-19 inpatients with lung involvement experiencing headache with those of 25 matched healthy controls with no headache history.
Results: Morning serum alpha-CGRPα levels, as measured by ELISA (Abbexa, UK), were increased in COVID-19 patients with headache (55.2±34.3 pg/mL) vs controls (33.9±14.0 pg/mL) (p<0.01).
Conclusions: CGRP levels are increased in COVID-19 patients experiencing headache in the acute phase of this disease, which could explain why headache frequently occurs in COVID-19 and strongly supports a role for trigeminal activation in the pathophysiology of headache in this viral infection.