bluuebunny/crossref_metadata_2025 huggingface dataset:
NOVELTIES AND EXPECTED IMPACT FROM CHANGES IN THE MACEDONIAN SOCIAL PROTECTION LEGISLATION
Authors: Bornarova Suzana , Bogoevska Natasha
Published: April 2023

The new Law on Social Protection (LSP in further text) in the Republic of North Macedonia was adopted in 2019 as part of a social reform process in line with the key strategic goals within the social protection system. The main aspects of the new regulation focus on types, procedures and realization of social protection activities, the system, organization and institutional framework of social protection, as well as cadres, financing and oversight and other issues of importance for realization of social protection. The new LSP introduced many systemic changes which are reasonably interlinked in the text and provide for unhindered accomplishment of the key ongoing processes in social protection, such as deinstitutionalization, decentralization and pluralization in social services delivery.

This article aims to identify impact and challenges related to implementation of the new social legislation, with focus on delivery and financing of social services. The content of this paper is a result of an analysis conducted in 2021 based on qualitative methodological approach and application of techniques of content analysis of relevant laws, bylaws, statistical data, reports, as well as expert interviews with representatives from relevant institutions – Ministry of Labour and Social Policy, Institute for Social Activities and representatives from national social service providers (public and private).
PERSPEKTIVE AKTERA OBRAZOVNE POLITIKE O UKLJUČIVANJU DECE TRAŽILACA AZILA U OBRAZOVNI SISTEM SRBIJE
Authors: Mihajlovic Tamara
Published: April 2023

Već duži vremenski period vlada veliko interesovanje za obrazovanje dece tražilaca azila od strane različitih organizacija, nacionalnih i međunarodnih institucija i eksperata. Izazovi poput kulturne različitosti, jezičke barijere i manjka ljudskih resursa deo su procesa integracije dece tražilaca azila u Srbiji. Cilj rada je prikaz i analiza perspektive aktera obrazovne politike o uključivanju dece tražilaca azila u obrazovni sistem Srbije. Istraživanje o perspektivama aktera obrazovne politike o uključivanju dece tražilaca azila u obrazovni sistem Srbije zasnovano je na intervjuima i fokusiranim grupnim intervjuima sa predstavnicima obrazovnih politika, nastavnicima i zaposlenima u nevladinim organizacijama uključenim u neformalno obrazovanje dece tražilaca azila. U ovom kvalitativnom istraživanju učestvovalo je ukupno 26 učesnika, od čega 6 predstavnika obrazovnih politika, 5 predstavnika nevladinih organizacija i 15 nastavnika. Glavni rezultati istraživanja ukazuju da je neophodno unaprediti sistem uključivanja dece tražilaca azila u obrazovni sistem, da je potrebno osmisliti i implementirati program zajedno sa akterima koji direktno rade sa decom, ojačati međusektorsku saradnju i ostvariti jasniju komunikaciju između različitih nivoa odlučivanja – lokalnog, regionalnog i državnog.
STAVOVI STRUČNIH RADNIKA/CA CENTARA ZA SOCIJALNI RAD U REPUBLICI SRBIJI O NAČINU MEDIJSKOG IZVEŠTAVANJA O NJIHOVOM RADU I MOGUĆIM PERCEPCIJAMA PROMENE
Authors: Skorupan Tamara
Published: April 2023

Negativno medijsko izveštavanje o socijalnom radu stvara iskrivljenu sliku u javnosti o ovoj profesiji, što kod korisnika budi odbojnost i nepoverenje, a kod stručnih radnika/ca nezadovoljstvo i ogorčenost. Predmet ovog rada je ispitivanje stavova stručnih radnika/ca centara za socijalni rad u Republici Srbiji o medijskom izveštavanju o njihovom radu. U izveštavanju medija izdvajaju se dva pristupa – tržišni i pristup profesionalne odgovornosti, a prema socijalnim službama pristup okrivljavanja. Cilj istraživanja je ispitati stavove stručnih radnika/ca centara za socijalni rad prema aktuelnom medijskom izveštavanju o njihovom radu. Ispitivanjem stavova uviđamo kako oni/e opažaju odlike i uzroke ove pojave, kakva osećanja kod njih takvo izveštavanje izaziva i kako utiče na njihov rad i odnos prema profesiji. Ispitane su percepcije uzroka aktuelnog medijskog izveštavanja i procene korisnosti različitih strategija za unapređenje izveštavanja. Razumevanje ovih percepcija stručnih radnika/ca ključno je za razvijanje odgovarajućih smernica za poboljšanje odnosa i komunikacije stručnih radnika/ca i predstavnika medija.
Análisis psicométrico de la Escala Triangular de Amor de Sternberg en una muestra de la ciudad de Arequipa
Authors: Arias Gallegos Walter L. , Rivera Renzo , Núñez Cohello Ana Lucía
Published: April 2023

En esta investigación de corte psicométrico se analizó la validez y la confiabilidad de la Escala Triangular de Amor de Sternberg (ETAS) de 45 ítems, en una muestra de 296 personas de la ciudad de Arequipa (ubicada al sur del Perú). El 56.1% fueron mujeres y el 43.9% fueron varones con una edad promedio de 40.7 años. La ETAS tiene tres componentes: Intimidad, Compromiso y Pasión. Para el procesamiento estadístico se aplicó el análisis factorial confirmatorio para analizar la estructura interna y la prueba alfa ordinal para estimar la confiabilidad. Se encontró que la ETAS tiene una estructura de tres factores, luego de eliminar 11 ítems debido a que saturaban en dos o más factores. La escala quedó reducida a 34 ítems, con adecuados índices de bondad de ajuste y una confiabilidad con índices superiores a .93 en cada uno de sus tres factores.
A Review on the Ksheerdhooma – a Unique Modality of Panchakarma
Authors: Singhal Dr. Shalu , Mangal Dr. Gopesh , Shukla Dr. Shubham
Published: April 2023

Abstract: ksheerdhooma is a sort of Swedana that falls under the umbrella of Nadi Sweda and Bashpa Swedana. A decoction of herbal medicines and cow's milk is blended and heated in this therapy. Steam vapours arise from the tube and are applied to the afflicted area of the patient's body or the entire body. It is commonly used to treat Jatrurdhwagata Vata Vyadhi. Swedana is also known as dhuma because steam is breathed via a gaping mouth. However, the process is similar to Swedana's. It can be classified as bashpa sweda, in which the face is fomented by vapours of the decoction. Ksheera dhuma with milk decoction vapours causes the body part to sweat, which opens the pores. This aids in the relief of inflammation and stiffness in the afflicted areas. This stimulates nerve endings and opens micro channels beneath the skin. Ksheera Dhooma is a Snigdha variant of Nadi Sweda, and its mode of action is determined by the drug used for therapy as well as procedural effects. Ksheerdhooma is an important swedana procedure, thus in this publication, we strive to establish a standard operative process and determine the efficacy of ksheerdhooma.
Unearthing of Medicinal Plants Using Deep Learning
Authors: Venkateswari Mrs. G. , Preethi T. Sai , Harini L. , Prasanna T. Lakshmi , Bai N. Prameela , Vani P. Manju
Published: April 2023

Abstract: Plants are an essential and valuable resource, which provides us with food, fiber, medicine, and all other basic needs. The efficacy of the dataset is revealed by comparing pre-trained deep convolution neural network architectures such as Inception V3 and Inception Resnet V2. This paper will focus on expanding the dataset to benefit stakeholders and thus, enriches society with the knowledge of herbs and their medicinal properties
Smart Checkout System for Supermarket
Authors: Kumari Mrs. Gavini Venkata Leela , Sowjanya Kopuri , Lakshmi Reddy Yamini Priya , Tejaswini Rettu , Katyayin Thotakura Sivai , Ahalya Uppalapati
Published: April 2023

Abstract: A smart checkout system for a supermarket can be designed using a combination of hardware and software solutions to provide an efficient and streamlined checkout experience for customers. Implementing a smart checkout system requires careful planning, testing, and evaluation to ensure it meets the needs of both the supermarket and its customers. However, the benefits of a smart checkout system can include improved efficiency, reduced costs, and increased customer satisfaction. Overall, a smart checkout system can provide significant benefits to supermarkets and their customers, making the shopping experience faster, more convenient, and more enjoyable.
Parkinson Detection using Machine Learning Algorithms
Authors: Gupta Sheetal , Ghanchi Saliha , Idrisi Shabista
Published: April 2023

Abstract: Parkinson’s Disease (PD is an irreversible, chronic, and progressive disorder, estimated to affect about ten million people worldwide affecting patient movement and feelings of motivation and reward. Motor symptoms of PD include tremor or shaking, which usually begins in one arm or hand, muscle rigidity or stiffness, and slowness, also referred to as bradykinesia. Signs and symptoms are unique to each person and the treatment should be tailored to each person’s individual needs. A recent survey of 492 people with PD found most believed self-monitoring would improve their understanding of PD, well-being, ability to cope, and communication with their health-care team. The overlap of symptoms with other neurological disorders leads to difficulties, delays, and errors in diagnosis, negatively impacting patients. A recent study of 1775 patients’ experiences of PD diagnosis identified the importance of early diagnosis. and found misdiagnosis occurred at first consultation for 15% of participants. This fallibility of clinical diagnosis is recognized and requires periodic diagnosis reviews. Participants are presented with three activities evaluating Patients Call Response, Fine Motor Movements and Memory. To evaluated Patients, Name Call Response, the application uses a Chatbot to communicate with the patient, and tries to ask questions by calling his name. On successful response a series of other questions are asked on patients likes and dislikes. Fine Motor Deficit is evaluated based on a Finger Tapping Task, the patient as to tap on two buttons shown on the phone screen alternatively. The data is collected after 2 minutes on Tapping and compared with threshold set by the Normal Group. The Memory Activity measures the time taken by the patient to solve the puzzle by finding the corresponding images. Patients are shown images of fruits that are illuminated one at a time and then asked to find the same in the grid.
Sinopsis de revisiones sistemáticas sobre el efecto clínico de la Ketamina en el paciente agitado
Authors: Berrouet-Mejía Marie Claire , Moreno-Quimbay Sebastián , Cardona Jaiberth , Patiño-Ospina Alber Johnny
Published: April 2023

Introducción: La literatura científica reporta estudios sobre la Ketamina, con alta heterogeneidad en los diseños, poblaciones, desenlaces y especialidades clínicas; sin embargo, no se encontró un documento que consolidara sistemáticamente la evidencia disponible y que oriente decisiones clínicas para el paciente agitado. Objetivo: Analizar la evidencia disponible en revisiones sistemáticas sobre el uso de Ketamina en paciente agitado. Materiales y métodos: Búsqueda sistemática en bases de datos multidisciplinarias. Se garantizó la exhaustividad del protocolo de búsqueda y selección de estudios, reproducibilidad y evaluación de la calidad metodológica según la herramienta Ameasurement Tool to Assess Systematic Reviews-2. Se realizó síntesis cualitativa de variables extraídas y estimación de proporciones con IC=95%. Resultados: Se tamizaron 134 estudios, 10 cumplieron los criterios del protocolo. Las revisiones sistemáticas incluyeron una población de 26.936 pacientes, la evidencia procede de dos series de caso, 7 estudios observacionales y 9 ensayos clínicos controlados. La Ketamina produce múltiples efectos adversos, algunos mayores a los causados por Midazolam. Conclusión: En algunos subgrupos se presentó alta proporción de efectos adversos respiratorios, neuropsiquiátricos y cardiovasculares, pero sin posibilidades de generalización a otros contextos. Es necesario mejorar la evidencia clínica y epidemiológica para la prescripción de Ketamina en el manejo de la agitación.
MEMAS Asistente de memoria a través de una aplicación inteligente para mejorar la condición de personas con Demencia
Authors: Romero Torres Mariano Esteban
Published: April 2023

The growth in life expectancy in the vast majority of the countries of the world has brought diseases typical of the elderly, among which are dementia syndromes, which mainly affect lifestyle and increase costs in health systems.

To know the estimate of the accelerated growth that Dementia is having in the world, the impact on the people involved in the process such as patients, families and professionals from studies carried out by the world health organization. Similarly, to establish how technology can help improve the condition of patients with dementia through the use of computational techniques within intelligent environments.

Identify the risk factors that may be associated with the development of Dementia early in life, such as: obesity, smoking, sedentary lifestyle, hypercholesterolemia, alcoholism and low education level. Taking into account the figures at the global level, the world health organization declared the issue of Dementia as a public policy that seeks to establish priority in national plans for the quality of medical care, optimize health services and achieve greater equity in the allocation of resources.
Formulación de una Conserva de Atún (Katsuwonus pelamis) y Ají Picante (Capsicum annuum L) como alternativa industrial en el sector atunero.
Authors: Marsiglia Fuentes Ronald , Hernández Blanco Miguel José , Mendoza Combatt Juan Camilo , Mendoza Combatt María Paulina
Published: April 2023

Tuna intake has acquired great importance due to the adoption of healthy lifestyles by the people who consume it, which is why the demands for quality and sensory characteristics are increasing every day at an international, national and local level. In the production of precooked tuna loins, by-products called grated and pieces are obtained; which are rejected by the client, so a specific use must be determined. Resolution 0148 of 2007 establishes technical requirements that canned tuna must meet. A canned tuna (Katsuwonus pelamis) and chili pepper (Capsicum annuum L. variety Baccatum) was developed. Two formulations with chili pepper (whole chili pepper and chopped chili pepper) were proposed seeking to meet the technical requirements of the Colombian resolution and the sensory acceptance of an untrained group of 22 panelists. Results were obtained according to the specified technical requirements of net weight, drained weight and oil percentage of the final product. The formulations with the addition of chili peppers had similar acceptance to canned commercial tuna (standard sample), for which reason the implementation of the formulation with chivato chili peppers is considered an innovative proposal that would bring nutritional, economic, and sociocultural advantages.
Gestión humana y cultura organizacional para la innovación: evidencias de una investigación con empresas de Colombia
Authors: Rozo Gutierrez Luz Mery , Vivares Jorge A. , Ospina Hernández Martha Catalina
Published: April 2023

The competitive environment that is imposing the fourth industrial revolution requires companies to be innovative and strong in development. However, technological development has been approached dominantly from hard technologies and soft technologies offer many possibilities of articulation, such is the case of human management and organizational culture, which can be seen as very important soft technologies that can enhance or inhibit innovation and therefore deserve a deep development in companies. In coherence, the objective of the research presented was to explore the relationship between human management, organizational culture and innovative performance. To meet the objective, information on these variables was collected in a sample of 140 companies in Colombia and a correlation analysis was carried out. It was found that human management and organizational culture are correlated with innovation, which is why companies must pay close attention to this type of variables related to soft technology, since they could determine the achievement of remarkable results in innovation. The novelty of the paper presented is based on a deep systematic review of the literature to establish how much this triad has been investigated in the state of the art. For this purpose, a search equation was established and applied in Scopus. 54 documents were identified including articles, book chapters and conference papers. A careful review and analysis of these allowed us to synthesize some relevant findings to relate human management and organizational culture to innovation. Furthermore, knowledge gaps were identified that offer possibilities for future research and are the main contribution of the paper presented.
Determinaciones económicas del Fintech en México
Authors: Ruiz de la Cruz Lizeth
Published: April 2023

Fintech is the combination between finance and technology, in terms of its emergence occurs in companies that provide financial services of higher quality and efficiency, creating a revolution in the financial market, leaving behind traditional companies. Hence, there is a reconfiguration in the expectations of

 

users, since the standards of experience by customers are higher.According to the (CONDUSEF) "These institutions seek to offer their services through digital platforms such as websites, mobile applications and social networks, which means that you can have access efficiently, agile and comfortably." Therefore, when we refer to Fintech, it is any innovation in the financial market, which leads to business schemes such as the appeasements of financial advisories, rating agencies, comparators of financial products, business management, among others.

The constant emergence of disruptive technologies, the speed with which innovation is generated in information and communication technologies, has caused the frontier of sectoral knowledge and consumer preferences to constantly shift and that to maintain the level of competitiveness requires a continuous effort of innovation, infrastructure expansion and dominance of new sectors/market segments. (Silva Nava, A., Ramos Medina, M,.C., 2017)
El neuromarketing. Una estrategia de posicionamiento en instituciones educativas
Authors: Carrillo Muñoz Yaritza , García Álvarez Aída Dinorah , De Paola García Yessy Alejandra
Published: April 2023

The memory of consumers towards a brand, specific product, service etc. is one of the most important points, being neuromarketing a valuable tool of market research used to know the behavior of the brain in front of different stimuli presented to consumers in order to take advantage of this information and create advertising pieces that allow to awaken emotions, sensations and feelings pleasing to consumers.
It is a fact that marketing must be accompanied by capabilities that allow formulating, making and evaluating correct decisions and strategies that contribute to achieving objectives and goals, these capabilities being the strategic, functional and operational of the market. (Hooley, Saunders and Piercy, 1998)
Within the concept of consumer benefit, service concepts such as the service offer and the service delivery system are taken into account, being the objective of educational marketing to develop strategies that enable in its administration and development the capture of its customers while responding to legal obligations and educational requirements in society. Educational marketing is an internal process in an educational organization to generate profitable or beneficial relationships with customers in order to attract new customers, create superior value, retain and increase the client portfolio by giving them satisfaction, and to have attractive prospects, an educational institution must provide a solid image and an appropriate educational program, at a price that students and their families are willing and able to afford, in a reasonably attractive location.
However, the most important finding is the user's perception of the service and their fidelity to continue in the educational institution that forms a knowledge profile.
Innovación en la industria restaurantera en tiempos de pandemia.
Authors: De La Cruz May Samuel , Hernández Triano Leonardo , Sanchez Ruiz José Guadalupe , Sandoval Caraveo María Del Carmen
Published: April 2023

A pure quantitative, descriptive and transversal research is presented with the objective of identifying in which areas the innovations registered by companies in the restaurant sector in southeastern México are presented. A probabilistic sample was obtained consisting of 204 restaurants operating in the State of Tabasco, México. The data collection technique was the survey, in which restaurant managers answered freely to a questionnaire with 91 items, finding that the area where the greatest innovation presents is innovation by product, while organizational innovation is the least registered in these organizations.
Gestión administrativa: desarrollo dentro de las empresas
Authors: Martínez Prats Germán , Morales Cárdenas Tomás Francisco , Silva Hernandez Francisca , Guzmán Fernández Candelaria
Published: April 2023

Companies are a great source of jobs as well as income through these economic entities has been able to meet the various social demands existing today, this through goods or services with which they generate resources to increase their wealth, companies over the years has had various evolutionary processes where each of them has had significant changes in growth both internally and external of these entities which helps to have a better management within them as well as allows to have better controls, improving their productivity and in turn having a greater profitability; Administrative management has an important role in business growth thanks to the fact that its resources are used more efficiently through an improvement in the performance of its activities as well as in the performance of each of the tasks that are done within the companies. The objective of this research work is to develop through a descriptive methodology the importance of administrative management in the development and progress of companies, which is why through the information collected it was demonstrated that administrative management is a fundamental part for the growth of companies, thanks to the efficient management of resources to improve the productivity and profitability of the entity.
SARS-CoV2 Wild-type and Delta VOC infection dynamics in a Paediatric cohort in India (South)
Authors: Penugonda Asha , Biswas Deepayan , Palani Murugan , Priya Sangeetha , Subashchandrabose Rajesh Kumar , Valiaveetil Koshy , Antonisamy Belavendra , Kompithra Rajeev , Mathew Leni , Moorthy Mahesh
Published: April 2023

Background: SARS CoV-2 infection virus dynamics, severity and immune
response are different in children and adults. Limited reports of the
differential impact of variants in children exist, and none have been
reported from LMICs. Methods: We recruited a prospective cohort of SARS
CoV-2 PCR positive children between November 2020 and May 2021 and
compared virus characteristics (viral load, wild-type or delta variant),
and disease severity strata (asymptomatic, mild-to-moderate and severe)
and levels of virus-specific antibody (anti-N and anti-S) immunity after
4-6 weeks. Results: Of 79 children recruited, asymptomatic,
mild-to-moderate and severe presentation was seen in 29%, 59% and 11%
subjects, respectively. Wild-type and delta presented with similar
disease severity. Anti-S antibody levels were higher than anti-N for
both variants (wild-type or delta) (p<0.0001). Anti-S was also
higher than anti-N among asymptomatic (p=0.02) and mild-to-moderate
disease (p<0.0001)). Both anti-S and anti-N antibody levels
were higher among children with higher virus loads [quartile (Q) 1
versus Q3, p<0.05]. Anti-S levels of wild-type were higher
than Delta-infected among low (Q3) virus loads (p=0.003). Mean Ct values
of wild-type (32.5) was higher than Delta infections (25.0), (p=0.0083)
among mild-to-moderate disease. Conclusions: Viral load drives antibody
response in children. Higher loads of Delta VOC resulted in robust
antibody response in mild-to-moderate disease, not seen in severe
disease. These finding are an indication of response to future SARS
CoV-2 variants and could inform targeted vaccination when introduced in
children.
Secondary Leaflet Tethering in Patients with degenerative mitral regurgitation and its Association with the Severity of Mitral Regurgitation
Authors: Ge Zhenyi , Hu Chunqiang , Tian Fangyan , Zhao Yingjie , Wang Yongshi , Kong Dehong , Li Wei , Xie Yashu , Ge Zhengdan , fulati zibire , Cheng Yufei , Guo Yao , Jiang Yingying , Pan Cuizhen , Shu Xianhong
Published: April 2023

Background The purpose of the study was to determine the
association between vena contracta area (VCA) and secondary leaflet
tethering among mitral valve prolapse (MVP) patients, and thus to
further identify and characterize an MVP with pathological leaflet
tethering (MVPt+) phenotype. Methods We prospectively evaluated
94 consecutive MVP patients with significant mitral regurgitation (MR)
and 20 healthy controls. MVPt+ group was defined as tenting volume index
(TVi) > 0.7 ml/m . The three-dimensional
(3D) geometry of mitral valve apparatus and VCA was measured with
dedicated quantification software. Results Of the 94 patients
with MVP and significant MR, 31 patients showed a TVi > 0.7
ml/m and entered the MVP with leaflet tethering
(MVPt+) group. In stepwise multivariate analysis, only prolapse volume
index and TVi was independently associated with 3D VCA. Apart from
marked left ventricular and annular enlargement, MVPt+ group presented
significantly higher frequency of leaflet flail, greater VCA, elevated
plasma levels of NT-proBNP and sPAP. ROC curve revealed that occurrence
of leaflet tethering is associated with a VCA ≥0.55 cm
in MVP patients. Conclusions Secondary
leaflet tethering is a significant mechanism behind severe degenerative
mitral regurgitation, resulting an MVPt+ phenotype featuring more
advanced morphological and hemodynamical characteristics .
The Soleymani and Collins Obstetric Morbidity Score (SaCOMS): a quantitative tool for measuring maternal morbidity from complex obstetric surgery such as placenta accreta spectrum (PAS)
Authors: Collins Sally , WEEKS Esme , MAJD Hooman SOLEYMANI , Addley Susan , Cavallaro Angelo
Published: April 2023

Objective: To describe a suggested version of the Clavien-Dindo
morbidity classification specific to obstetrics and employ it to build a
cumulative morbidity score which fully reflects the ‘patient
experience’. To demonstrate the utility of this novel system in a cohort
of women with Placenta Accreta Spectrum (PAS).   Design: Delphi
consensus and retrospective application of the resulting scores to
morbidity from PAS surgery.   Setting: UK Tertiary referral
centre for PAS.   Population: Women who had caesarean
hysterectomy for PAS.   Methods: The Clavien-Dindo
classification was modified to reflect obstetric procedures and a
quantitative morbidity measure, the Soleymani and Collins Obstetric
Morbidity Score (SaCOMS), was developed based on this. Both were then
validated using a Delphi consensus of experts in PAS and retrospectively
applied to a cohort of 54 women with PAS.   Main Outcome
measures: Delphi consensus of >80%, binary outcome of
adverse event or not and quantitative values from the SaCOMS.  
Results: Clinicians with expertise in PAS believe that the
Modified Obstetric Clavien-Dindo classification system and the novel
SaCOMS tool can improve assessment of maternal morbidity, and better
reflect the ‘patient experience’. Application to the PAS cohort
demonstrates that surgery by gynae-oncological surgeons may be
associated with decreased incidence and cumulative morbidity outcomes
for women with PAS, especially those with the most severe presentation.
    Conclusions: This study presents a clinically useful
obstetric-specific classification system for surgical morbidity. SaCOMS
also provides a quantitative reflection of the full patient- journey
experienced as a result of surgical complications enabling a more
patient-centred representation of morbidity.
The Potential Values of Ferulic Acid in Ophthalmic Diseases
Authors: Wang Yani , Wang Zhaoyang , Yao Tengteng , Wang Jiajing , Liu Yuhao
Published: April 2023

Ferulic acid, as a common polyphenol in Chinese herbal medicine, is
widely found in rice, vegetables and fruits. It has important
antioxidant effects and has an effect in a variety of diseases. However,
the mechanism of its antioxidant function is very complex, including
regulation of pro-inflammatory factors, scavenging free radicals and
inhibition of lipid peroxidation. The signaling pathway of ferulic acid
in exerting its antioxidant effect has not been fully found. Recent
studies have found that ferulic acid has a very important potential
application value in the treatment of ophthalmic diseases, including
glaucoma, cataract, age-related macular degeneration, etc. This paper
reviews the effects and referring signaling pathway of ferulic acid in
eye diseases and conclude the potential signal pathways of ferulic acid
in order to provide new ideas for traditional Chinese medicine in the
treatment of eye diseases.
The interaction of crack and dislocations in cyclic loading in the body-centered cubic (BCC) crystal
Authors: Jiang Xiaoyu , Sheng Yue , Yang Hongda , Zhang Jiding
Published: April 2023

In this paper, the propagation rate of the cracks at different grain
sizes with different grain boundary (GB) angles have been simulated.
During loading, the crack tip (CT) emits dislocations, which are
distributed on the slip plane (SP) in front of the crack, and may
accumulate at the GB, during which the crack expands forward. If the
conditions are met during unloading, the dislocations will rebound.
Dislocation annihilation will occur when distance of dislocation
emitting is less than the distance of dislocation rebound. The
annihilation of the dislocations have an impact on the next loading. The
calculation results show that the crack propagation rate (CPR) is
related to both the grain size and the angle of the GB. The CPR
increases in larger crystals and in larger angle GBs. And the number of
annihilation dislocations and the number and distribution of existing
dislocations will obviously affect the next loading step.
Netosis -A double-edged sword in the Pathogenesis of LONG COVID
Authors: Aden Durre , sharma vagisha , zaheer sufian , RANGA SUNIL
Published: April 2023

The emergence of COVID-19 as a global pandemic has had far-reaching
effects on the health of individuals worldwide. Although there has been
a decrease in the severity of the disease, there is a growing concern
about the long-term impact of COVID-19 on the health of individuals,
particularly cardiovascular complications, known as Long-COVID, which
can significantly increase morbidity and mortality rates in people
recovering from COVID-19 in the recent past. The severity of COVID-19
has been linked to various factors, including the role of neutrophils
and neutrophil extracellular traps (NET). These extracellular webs,
composed of chromatin, microbicidal proteins, and oxidant enzymes, are
released by neutrophils to fight infections. However, if not properly
regulated, NETs can lead to thrombo-inflammatory states and
microangiopathy in the body, resulting in complications such as sepsis,
thrombosis, and respiratory failure. Understanding the detailed
pathophysiology and association of NETs with the prognosis of COVID-19
infection is crucial for future implications and management. The purpose
of this review is to analyze the potential contribution of NETosis in
the pathophysiology of COVID-19 and its subsequent complications apart
from its beneficial effect. This may provide insight into potential
therapeutic interventions for COVID-19 patients.
Gastroenterology services for patients with Cystic Fibrosis across Australia and New Zealand: A multi-stakeholder assessment of patients’ and professionals’ perspectives
Authors: E Tamarah Katz , Wakefield Claire E. , Signorelli Christina , Day Andrew , Vernon-Roberts Angharad , Ooi Chee Y.
Published: April 2023

Introduction: Gastrointestinal (GI) symptoms are common in
individuals with Cystic Fibrosis (CF). International research has
highlighted that GI care for this group of patients is lacking.
Gastroenterology services to CF clinics across Australasia are yet to be
examined. This study aimed to describe the current service delivery
model and to identify areas for improvement that may lead to positive
patient outcomes. Methods: CF clinicians (dietitians, clinical
nurse consultants, respiratory consultants), gastroenterologists (GE),
and patients or their carers from Australia and New Zealand (NZ) were
surveyed online to gather their opinions on CF gastroenterology services
provided in their region. Data were analysed using descriptive
statistics (frequencies and percentages). Likert scale questions were
analysed by grouping responses 1-5 and 6-10, presented alongside the
median and interquartile range (IQR). Mann-Whitney U and chi-square
tests were used to look at differences between stakeholder groups.
Results: One hundred and fifty-seven health professionals and
172 patients or their carers completed the survey. Results showed that
the current GI model of care is predominantly a publicly funded service
delivered outside of CF clinic time. GE are largely not integrated into
the CF team and report a lack of training opportunities. There is a
higher level of dissatisfaction with the current service model in NZ
than Australia. Discussion: No stakeholder group deemed the
current CF gastroenterology service model as adequate, leaving
opportunity for transformations in this field. Ideally the data from
this study will invigorate the need for promotion and integration of GI
services that would ultimately benefit the whole CF community.
A Novel Method for Prediction of the Optimal Ovarian Stimulation Protocol during ICSI Cycles Using AMH Levels Estimate
Authors: MA Behery
Published: April 2023

Individualization of ovarian stimulation protocol in the intracytoplasmic sperm injection allows gynecologists to treat and manage infertile females according to their unique physiognomies. Ideally this would increase the clinical pregnancy rate, lessen the iatrogenic hazards such as ovarian hyperstimulation syndrome, and decline the risk of cancellation of cycles. AntiMüllerian hormone (AMH) emitted via the granulosa cells from small growing follicles in ovary, is a key player in preserving the “follicle pool”. The aim of this work is to explore whether AMH could be a predictive marker for the selection of the optimal ovarian stimulation protocol for cases that undergo intracytoplasmic sperm injection. This study was a retrospective study, that analyzed data from 1005 patients whose underwent intracytoplasmic sperm injection at a university ART unit from January 2017 to December 2020 where 3 groups were validated according to the level of AMH. group1, includes patients with serum AMH<1 ng/ml, group2, includes patients with AMH 1-3 ng/ml and group3 with AMH>3 ng/ml. Our results had shown that the long agonist protocol had the superlative outcome in all groups of the study. Serum AMH levels concentration correlated strongly with oocyte yield. AMH level should be determined before embarking on COS protocol. Surprisingly, our results revealed that long agonist protocol had the best outcome in all groups.
Comparative Analysis of Sound Response from Simple and Fuzzy Algorithm in Saron Virtual Reality
Authors: Ayub Her Pracoyo  , Clara Hetty Primasari  , Albertus Joko Santoso  , Thomas Adi Purnomo Sidhi  , Yohanes Priadi Wibisono  , Djoko Budiyanto Setyohadi
Published: April 2023

Analisis Komparatif Respon Suara dari Algoritma Sederhana dan Algoritma Fuzzy di Saron Virtual Reality. Game virtual reality dengan konsep alat musik memerlukan respon suara yang dinamis karena musik tidak lepas dari perasaan manusia dalam memainkannya. Suara yang bagus dalam sebuah game tergantung pada kesesuaiannya dengan situasi game. Keterbatasan waktu dan tempat menjadi permasalahan dalam melakukan variasi perekaman sampel suara. Jika sampel suara yang diambil terbatas dan diterapkan dengan algoritma sederhana kemungkinan terdengar repetitif dan kurang sesuai dengan dinamika suara musik sesuai kehidupan nyata manusia. Oleh karena itu, pada penelitian ini dilakukan komparasi implementasi antara algoritma sederhana dengan algoritma fuzzy pada suara game Gamelan Saron. Metode pengolahan data yang digunakan adalah analisis komparatif dan data diperoleh dari hasil eksperimen responden. Pada skala persetujuan satu sampai lima, mayoritas responden setuju adanya perubahan signifikan yang lebih baik setelah diberikan algoritma fuzzy yang digambarkan dengan nilai rata-rata 4,1.Kata Kunci: suara, gamelan, Saron, dinamika, fuzzy
Comparative Analysis of Sound Response from Simple and Fuzzy Algorithm in Saron Virtual Reality. Virtual reality games with musical instruments require a dynamic sound response because playing the instrument requires real human feelings. A good sound in a game depends on its suitability for the game situation. Time and place limitations are a problem in recording variations in sound sample recording. If the sound samples taken are limited and a simple algorithm is applied, it may sound repetitive and not match the dynamics of music according to real human life. Therefore, in this study, a comparison of a simple algorithm with the fuzzy algorithm was carried out in the Gamelan Saron game. The data processing method used is a comparative analysis obtained from the experimental results of the respondents. On the agreement scale of one to five, most respondents agree that there is a better significant change after being given a fuzzy algorithm described by a mean value of 4.1.
Keywords: sound, gamelan, Saron, dynamics, fuzzy
Klasik İnsan-Kuantum İnsan-4: Yeni Materyalizm ve Gerçeklik
Authors: Yüksel Atila
Published: April 2023

Geleneksel gerçeklik tanımlarımızın kuantum mekaniğinin bakış açısıyla tanımlanan gerçekliği kapsamaktan uzak olduğunu düşünüyorum. Kuantum mekaniği ışığında, mevcut gerçeklik tanımımızın yeniden yazılması gerektiği açıktır. Çünkü kuantum mekaniğine göre gerçeklik fiziki değildir, enerjidir ve kesin değildir olasılıksaldır. Klasik İnsan-Kuantum İnsan serisinin üçüncü makalesinde bahsedilen gerçekliğe ilişkin iki temel karşıt görüşe (materyalist-idealist) ek olarak, kuantum mekaniği ile paralel görünen ve çıplak gözle gözlenemeyen dünya ile gerçek dünya arasında kesin bir ayrım yapan üçüncü bir görüş daha vardır. Gerçekliğe, özellikle de devam eden vitalizm-mekanizim tartışmasına ışık tutma çabasında yeni materyalizm kavramına, Bennet'in (2010) "vitalist materyalizm" , Barad'ın (2007) faili gerçekçilik ve Bhaskar'ın (2015) katmanlı gerçeklik kavramlarına dikkat etmemiz gerektiğini düşünüyorum.
Pengembangan Multimedia Interaktif Menggunakan Adobe Flash Cs 6 Pada Mata Pelajaran Bahasa Indonesia KelaS X SMA
Authors: Jannah Hanifatul , Zen Zelhendri
Published: April 2023

ABSTRAK

Penelitian ini dilakukan untuk menghasilkan produk multimedia interaktif menggunakan Adobe Flash CS 6 pada mata pelajaran Bahasa Indonesia kelas X SMA yang valid dan praktis. Jenis penelitian ini adalah penelitian pengembangan yang dikenal dengan istilah Research and Development (R&D), menggunakan model pengembangan Borg and Gall yang telah disederhanakan oleh Tim Puslitjaknov. Adapun prosedur pengembangan pada penelitian ini terdiri dari 5 tahap yaitu: (1) Analisis Produk yang akan dikembangkan, (2) pengembangan produk awal, (3) validasi ahli dan revisi, (4) Uji coba lapangan skala kecil dan revisi Produk, (5) Uji coba lapangan skala besar dan Produk akhir. Uji validitas produk dilakukan oleh 3 validator yaitu 1 orang validator ahli materi di SMA N 2 Rambatan dan 2 orang validator ahli media dosen departemen KTP FIP UNP. Uji coba produk dilakukan kepada 20 orang siswa kelas X di SMA N 2 Rambatan dengan tujuan untuk mengetahui kepraktisan produk yang dikembangkan. Pengembangan multimedia interaktif yang hasil penilaiannya dari 1 orang validator materi dan 2 orang validator media, masing-masing sudah dikategorikan “Valid”, yang mana mendapatkan nilai 4,85 untuk materi, dan 4,86 untuk media, namun terdapat beberapa revisi pada materi serta media. Hasil analisis uji coba kepraktisan memperoleh nilai rata-rata 4,65 sehingga produk media pembelajaran berada pada kategori “Praktis”.Berdasarkan hasil uji validitas, dan praktikalitas, dapat disimpulkan bahwa multimedia Interaktif yang di hasilkan ini layak sehingga dapat digunakan pada mata pelajaran Bahasa Indonesia Kelas X SMA.
Numerical implementation of method of variable parameters in solving elastic-plastic problems based on graph model of elastic body
Authors: Tyrymov Alexander Aleksandrovich , Shvedov Evgeniy Gennad'evich
Published: April 2023

The article highlights the results of using a graph model of a continuous medium for solving elastic-plastic problems. The stress-strain state is determined by the method of variable parameters based on the deformation diagram of the medium material. The method is based on the representation of the defining elastic plasticity relations in the form of equations of linear elasticity theory, but with variable elasticity parameters. The computational process is an iterative procedure in which each successive approximation is reduced to solving a linear elastic problem. The problem is solved by the graph method. The stress-strain state is found by a non-standard numerical method in which a solid body is represented by a discrete model in the form of an oriented graph. Concrete examples show the high efficiency of the method in comparison with the traditional finite element method. The increased accuracy of calculations, even when using coarse grids, is ensured by the fact that: 1) the vertex and contour laws of graph theory implement the equations of equilibrium and compatibility of deformations for the element as a whole; 2) the equilibrium equations are performed locally by the volume of the element. The problems of the elastic-plastic bending of the console and the elastic-plastic state of a plate with a circular hole are solved as examples. Comparison of the obtained results with the solutions of these problems by other methods showed a good match. The high accuracy of calculations makes it possible to use the iterative procedure of the method of variable elasticity parameters as a subroutine in the application package created for the graph method.
Mathematical modeling ethylene polymerization process in autoclave reactor with stirrer
Authors: Istomin Andrey Leonidovich , Krivov Maksim Viktorovich , Istomina Alena Andreevna , Golovkova Elena Aleksandrovna
Published: April 2023

Building a mathematical model of the polymerization reactor is necessary to determine the dependencies between the input variables, the technological mode and the output variables of the ethylene polymerization process in an autoclave reactor with a stirrer, as well as to analyze the effect of the reactor design parameters on efficiency. A deterministic mathematical model developed on the basis of analysis of the physico-chemical regularities of the ethylene polymerization process is proposed to solve these problems. There is shown a schematic diagram of ethylene polymerization indicating the flows of substances and energy, a description of the process, the mechanism of chemical kinetics of ethylene polymerization, a system of assumptions simplifying the construction of a mathematical model, equations of a mathematical model of an ethylene polymerization reactor in an autoclave reactor with a stirrer. The autoclave ethylene polymerization reactor is presented as a cascade of ideal mixing apparatus to describe each of the reactor zones. The rates of chemical reactions of initiation, growth and chain breakage are expressed in accordance with the law of acting masses. The mathematical model in its final form is a system of ordinary differential equations for describing each of the reactor zones. The initial numerical values of variables and parameters for modeling ethylene polymerization in the autoclave reactor are given. The results of numerical experiments are shown, and the influence of various factors on the output variables of the ethylene polymerization process is investigated. The proposed mathematical model can be used to optimize the technological regime of the ethylene polymerization process in an autoclave reactor with a stirrer, as well as to analyze the influence of the design parameters of the reactor on its efficiency.
ХУДОЖНЯ РЕПРЕЗЕНТАЦІЯ ПАНДЕМІЇ В РОМАНІ ТОМАСА НЕША «НЕВДАЛИЙ МАНДРІВНИК»
Authors: Федоряка Людмила , Ревенко Вікторія
Published: April 2023

На літературній орбіті пізнього англійського Ренесансу постать Томаса Неша (1567–1601?) займає особливе місце. На відміну від творчих побратимів, він спробував себе у всіх відомих тоді видах художнього пись- менства: його перу належить із десяток різножанрових творів. Деякі жанри були ним особливо шановані – передусім, памфлет, який справедливо назвати його професійною домінантою. У декількох різновидах цих викривальних творів Нешеві вдалося сповна реалізувати свої сатиричні погляди, завдяки яким він зажив слави «англійського Ювенала». Унікальне художнє досягнення Неша полягає в тому, що абсолютно всі його твори просякнуті сатиричними інтен- ціями, спрямованими на соціальні проблеми і моральні вади представників пізноренесансного суспільства. Окремо варто говорити про те, що Неш є автором першого єлизаветинського «novel» «Невдалий мандрівник» («Тhe Unfortunate Traveller» 1593), який постає сатиричною мозаїкою тогочасного європейського життя. Серед багатьох злободенних тем, порушених автором у цьому творі, слід виділити інтерпретацію теми пандемії. Пильну увагу читачів Неш привертає до відомої на початку XVI ст. англійської «пітної хвороби». Різнобічне зображення епідемії (симптоми, вияв, перебіг, лікувальна практика) дозволило Нешеві створити доволі цілісну картину цього медичного феномену. Варто припустити, що ключовою причиною появи таких «медикоподібних» описів у романі є авторське переконання в тому, що вони спроможні допомогти його сучасникам усвідомити специфіку минулої трагедії і з урахуванням досвіду попередників сприяти подоланню нинішньої пандемії (роман був написаний під час епідемії «чорної смерті» в Лондоні); а читачам наступних поколінь – бути інтелектуально і морально підготовленими до нових спалахів. З точки зору літературознав- чої специфіки романні фрагменти на пандемійну тематику можна характеризувати як белетризовані історичні оповід- ки, адже домінувальний складник історичної хроніки модифікується за рахунок описовості, діалогічності і риторики.