bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance Analysis of Mixed Rayleigh and F Distribution RF-FSO Cooperative Systems with AF Relaying
Authors: Han Liqiang , Liu Xuemei , Wang Yawei , Li Boyu
Published: July 2022

This paper proposes a dual-hop mixed radio frequency-free-space optical (RF-FSO) cooperative system with amplify-and-forward (AF) relaying. The RF link is subject to Rayleigh fading and the FSO link is assumed to follow F-distributed fading with pointing error. The different types of detection, including intensity modulation with direct detection (IM/DD) and coherent heterodyne detection (HD), are considered. The closed-form expressions for the cumulative distribution function (CDF), the moment generating function (MGF), and the moments of end-to-end signal-to-noise ratio (SNR) are derived. Furthermore, closed-form expressions for the outage probability, average bit error rate (BER), and ergodic capacity are presented. Asymptotic outage probability expressions are derived to obtain additional insights into the system performance. It is shown that the HD technique exhibits better performance than an IM/DD technique. The system performance is deteriorated by atmospheric turbulence and pointing error. Finally, analytical results are confirmed by Monte Carlo simulations.
Cellular Positioning in an NLOS Environment Applying the COPSO-TVAC Algorithm
Authors: Lukić Stevo , Simić Mirjana
Published: July 2022

Non-Line-of-Sight (NLOS) conditions are created by blocking the direct path between the transmitter and receiver, resulting in an increased signal propagation path. To mitigate the Time of Arrival (TOA) measured errors caused by the NLOS phenomenon in cellular radio positioning, we use the Maximum Likelihood (ML) estimation method in this work. The cost function of the ML estimator is usually a high-dimensional, nonlinear, and multimodal function, where standard deterministic optimization techniques cannot solve such problems in real-time and without significant computing resources. In this paper, effective metaheuristic algorithms based on the enhanced variants of Particle Swarm Optimization (PSO) are applied for the optimal solution of the ML problem and efficiently determine the mobile station location. Time-Varying Acceleration Coefficients (TVAC) are introduced into the standard PSO algorithm to enhance the global search and convergence properties. The resulting algorithm is known as PSO-TVAC. To further improve the performance of the metaheuristic optimization, we suggest adding Chaos Search (CS), Opposition-Based Learning (OBL), and TVAC strategy to the PSO process. The simulation results show that the proposed metaheuristic algorithm named the Chaotic Opposition-based PSO-TVAC (COPSO-TVAC) can reach the Generalized Cramer–Rao Lower Bound (GCRLB) and surpass the original PSO, PSO-TVAC, and the presented conventional optimization algorithms.
Improving the Inertial Response of a Grid-Forming Voltage Source Converter
Authors: Dolado Juan , Rodríguez Amenedo Jose Luis , Arnaltes Santiago , Eloy-Garcia Joaquín
Published: July 2022

In recent years, the use of synchronous generators (SGs) has been displaced due to the increased use of renewable energy sources. These types of plants mostly use power electronic converters to connect to power grids, which, due to their mode of operation, cannot provide the same services. This paper analyzes the synchronization of Grid-Forming converters (GFM) without phase-locked loop (PLL) through the active power control loop. Stability analysis shows that when increasing the emulated moment of inertia in a voltage source converter (VSC) using grid-forming control, the system becomes oscillatory. The paper proposes a novel compensation mechanism in order to damp the system oscillation, allowing the implementation of inertia emulation. Finally, the real-time implementation is executed using a Hardware in the Loop experimental set-up. The response of VSC under grid disturbances is simulated in a real time simulator, while the proposed control system is implemented in a real-time controller platform.
An Intelligent Method for Detecting Surface Defects in Aluminium Profiles Based on the Improved YOLOv5 Algorithm
Authors: Wang Teng , Su Jianhuan , Xu Chuan , Zhang Yinguang
Published: July 2022

In response to problems such as low recognition rate, random distribution of defects and large-scale differences in the detection of surface defects of aluminum profiles by other state-of-the-art algorithms, this paper proposes an improved MS-YOLOv5 model based on the YOLOv5 algorithm. First, a PE-Neck structure is proposed to replace the neck part of the original algorithm in order to enhance the model’s ability to extract and locate defects at different scales. Secondly, a multi-streamnet is proposed as the first detection head of the algorithm to increase the model’s ability to identify distributed random defects. Meanwhile, to overcome the problem of inadequate industrial defect samples, the training set is enhanced by geometric variations and image-processing techniques. Experiments show that the proposed MS-YOLOv5 model has the best mean average precision (mAP) compared to the mainstream target-detection algorithm for detecting surface defects in aluminium profiles, whereas the average single image recognition time is within 19.1FPS, meeting the real-time requirements of industrial inspection.
Experimental Realization of 16-Pixel Terahertz Receiver Front-End Based on Bulk Silicon MEMS Power Divider and AlGaN/GaN HEMT Linear Detector Array
Authors: Zhu Kaiqiang , Ding Qingfeng , Mao Tong , Tang Xiuming , Xiao Yu , Qin Hua , Sun Houjun
Published: July 2022

A 16-pixel terahertz (THz) receiver front-end working at room temperature was designed, built, and measured in this paper. The designed receiver front-end is based on the antenna-coupled AlGaN/GaN high-electron-mobility transistor (HEMT) THz linear detector array (TeraLDA) and a 16-way THz power divider. The local oscillator (LO) signal is divided by the power divider into 16 ways and transmits to the TeraLDA. Each detector contains a planar unified antenna printed on a 150 μm-thick sapphire substrate and a transistor fabricated on AlGaN/GaN heterostructure. There are 16 silicon hemispheric lenses located on the TeraLDA to increase the responsivity of the TeraLDA. The focus of each lens is aligned in the center of the TeraLDA pixels. Depending on different read out circuits, the receiver front-end could work in homodyne and heterodyne modes. The 16-way power divider is a four-stage power divider that consists of fifteen same 2-way dividers, and was fabricated by bulk silicon microelectromechanical systems (MEMS) technology to achieve low insertion loss (IL). This designed receiver front-end could be a key component of a THz coherent focal plane imaging radar system, that may play a crucial role in nondestructive 3D imaging application.
ViV-Ano: Anomaly Detection and Localization Combining Vision Transformer and Variational Autoencoder in the Manufacturing Process
Authors: Choi Byeonggeun , Jeong Jongpil
Published: July 2022

The goal of image anomaly detection is to determine whether there is an abnormality in an image. Image anomaly detection is currently used in various fields such as medicine, intelligent information, military fields, and manufacturing. The encoder–decoder structure, which learns a normal-looking periodic normal pattern and shows good performance in judging anomaly scores through reconstruction errors showing the differences between the reconstructed images and the input image, is widely used in the field of anomaly detection. The existing image anomaly detection method extracts normal information through local features of the image, but the vision transformer base and the probability distribution are generated by learning the global relationship between image anomaly detection and an image patch that can locate anomalies to extract normal information. We propose Vision Transformer and VAE for Anomaly Detection (ViV-Ano), an anomaly detection model that combines a model variational autoencoder (VAE) with Vision Transformer (ViT). The proposed ViV-Ano model showed similar or better performance when compared to the existing model on a benchmark dataset. In addition, an MVTec anomaly detection dataset (MVTecAD), a dataset for industrial anomaly detection, showed similar or improved performance when compared to the existing model.
Discussion of Wind Turbine Performance Based on SCADA Data and Multiple Test Case Analysis
Authors: Astolfi Davide , Pandit Ravi , Terzi Ludovico , Lombardi Andrea
Published: July 2022

This work is devoted to the formulation of innovative SCADA-based methods for wind turbine performance analysis and interpretation. The work is organized as an academia–industry collaboration: three test cases are analyzed, two with hydraulic pitch control (Vestas V90 and V100) and one with electric pitch control (Senvion MM92). The investigation is based on the method of bins, on a polynomial regression applied to operation curves that have never been analyzed in detail in the literature before, and on correlation and causality analysis. A key point is the analysis of measurement channels related to the blade pitch control and to the rotor: pitch manifold pressure, pitch piston traveled distance and tower vibrations for the hydraulic pitch wind turbines, and blade pitch current for the electric pitch wind turbines. The main result of this study is that cases of noticeable under-performance are observed for the hydraulic pitch wind turbines, which are associated with pitch pressure decrease in time for one case and to suspected rotor unbalance for another case. On the other way round, the behavior of the rotational speed and blade pitch curves is homogeneous and stable for the wind turbines electrically controlled. Summarizing, the evidence collected in this work identifies the hydraulic pitch as a sensible component of the wind turbine that should be monitored cautiously because it is likely associated with performance decline with age.
Influence of Different Ambient Temperatures on the Discharge Performance of Square Ternary Lithium-Ion Batteries
Authors: Wang Xingxing , Zhang Yujie , Ni Hongjun , Lv Shuaishuai , Zhang Fubao , Zhu Yu , Yuan Yinnan , Deng Yelin
Published: July 2022

Electric vehicles have a promising development prospect. As its core component, lithium-ion power battery plays a crucial role in different application scenarios. Aiming at the availability and safety of square ternary lithium batteries at different ambient temperatures and different current rates, charge-discharge cycle experiments are carried out to study the voltage, temperature and capacity changes of lithium batteries. The voltage plateau characteristics of lithium batteries under different working conditions are explored. The results show that when discharging at current rates of 0.1C, 0.25C, 0.5C, 0.75C, and 1C under the ambient temperature of −5 °C, 10 °C, 25 °C, and 40 °C, the terminal voltage of the battery changes smoothly during the voltage plateau period, the rise of the surface temperature has not reached the peak value, and the discharge capacity accounts for about 50%. The battery has better working performance. While at the ambient temperature of −20 °C, the discharge capacity accounts for the highest proportion in the stage from the open-circuit voltage to the initial voltage of the plateau period. The research results can provide a reference for the modeling and control strategy design of lithium-ion power batteries in the energy storage system of electric vehicles.
Correction: Zheng et al. Changes in the Soil Labile Organic Carbon Fractions following Bedrock Exposure Rate in a Karst Context. Forests 2022, 13, 516
Authors: Zheng Wei , Rao Chengjiao , Wu Qian , Wang Enwen , Jiang Xingjian , Xu Yichen , Hu Lei , Chen Yazhen , Liang Xiaocui , Yan Wende
Published: July 2022

The authors wish to make the following corrections to this paper [...]
Recent Trends in Biogenic Gas, Waste and Wastewater Fermentation
Authors: Rene Eldon R. , Veiga María C. , Kennes Christian
Published: July 2022

In recent years, the optimization of bioprocesses for the removal of pollutants from industrial biogenic gas emissions, waste and wastewater has been the focus of intensive research. Recently developed technologies not only aim to remove such pollutants, but also to valorize them, whenever possible, through their bioconversion into useful added-value products. In this domain of progressive research, lab-, pilot-, and demonstration-scale studies are dealing with the fermentation of biogenic gases (e.g., CO2, CO, and CH4), waste or wastewater to produce a range of biofuels and valuable products, based on the activity of pure or mixed cultures of native or recombinant aerobic and anaerobic bacteria, algae, or yeasts as biocatalysts. Waste can also be converted to syngas, which can subsequently be fermented as well. A broad range of bioproducts can be obtained, e.g., biofuels and several other platform chemicals and products. This environmentally-friendly biorefinery approach addresses the need to build modern societies according to the concept of a circular economy, and yields products of commercial interest. Different examples of such approaches are described in this collection of scientific reports.
European Consumers Attitudes toward Ethnic Foods: Case of Date Fruits
Authors: El Hadad-Gauthier Fatima , Monhoussou Bleoussi Bernardin , Hammoudi Abdelhakim , Perito Maria Angela
Published: July 2022

This study focuses on the perception of ethnic foods by European consumers. The aim of this work is to enrich the literature on the analysis of consumer perception of ethnic foods by focusing on the socio-demographic characteristics of consumers, the possible role played by product attributes, psychographic characteristics, and willingness to pay for these products, specifically date fruits. We surveyed a representative sample of 1123 Italian and French consumers. Using an ordered logit model, we found that, as for any other product, geographical indication, region of production, organic character, and fair trade are attributes that individuals consider in their purchase decisions for ethnic foods. Similarly, country of origin is a source of quality for ethnic foods such as dates. The results reveal that women, more educated individuals, and Generation Z (younger individuals) have a higher willingness to pay for organic, fair trade, and GI-labeled ethnic foods. Finally, this willingness to pay is driven more by product knowledge than by cognitive closeness to the ethnic food.
Themes of Biological Inheritance in Early Nineteenth Century Sheep Breeding as Revealed by J. M. Ehrenfels
Authors: Poczai Péter , Santiago-Blay Jorge A.
Published: July 2022

Among the so-called sheep breeders interested in biological inheritance in the late eighteenth and early nineteenth centuries and well before Gregor Johann Mendel, J. M. Ehrenfels (1767–1843) produced some of the most cogent writings on the subject. Although earlier in his career Ehrenfels was a strong advocate of environmental factors as influencers on the appearance of organisms, as a result of his discussions with Imre Festetics, he became convinced that whatever is passed from parents to progeny is more important and it is dependent on a “genetic force, the mother of all living things”. The sheep breeders kept issues of inheritance at the forefront of the Central European cultural context late into the nineteenth century.
A Primer Genetic Toolkit for Exploring Mitochondrial Biology and Disease Using Zebrafish
Authors: Sabharwal Ankit , Campbell Jarryd M. , Schwab Tanya L. , WareJoncas Zachary , Wishman Mark D. , Ata Hirotaka , Liu Wiebin , Ichino Noriko , Hunter Danielle E. , Bergren Jake D. , Urban Mark D. , Urban Rhianna M. , Holmberg Shannon R. , Kar Bibekananda , Cook Alex , Ding Yonghe , Xu Xiaolei , Clark Karl J. , Ekker Stephen C.
Published: July 2022

Mitochondria are a dynamic eukaryotic innovation that play diverse roles in biology and disease. The mitochondrial genome is remarkably conserved in all vertebrates, encoding the same 37-gene set and overall genomic structure, ranging from 16,596 base pairs (bp) in the teleost zebrafish (Danio rerio) to 16,569 bp in humans. Mitochondrial disorders are amongst the most prevalent inherited diseases, affecting roughly 1 in every 5000 individuals. Currently, few effective treatments exist for those with mitochondrial ailments, representing a major unmet patient need. Mitochondrial dysfunction is also a common component of a wide variety of other human illnesses, ranging from neurodegenerative disorders such as Huntington’s disease and Parkinson’s disease to autoimmune illnesses such as multiple sclerosis and rheumatoid arthritis. The electron transport chain (ETC) component of mitochondria is critical for mitochondrial biology and defects can lead to many mitochondrial disease symptoms. Here, we present a publicly available collection of genetic mutants created in highly conserved, nuclear-encoded mitochondrial genes in Danio rerio. The zebrafish system represents a potentially powerful new opportunity for the study of mitochondrial biology and disease due to the large number of orthologous genes shared with humans and the many advanced features of this model system, from genetics to imaging. This collection includes 15 mutant lines in 13 different genes created through locus-specific gene editing to induce frameshift or splice acceptor mutations, leading to predicted protein truncation during translation. Additionally, included are 11 lines created by the random insertion of the gene-breaking transposon (GBT) protein trap cassette. All these targeted mutant alleles truncate conserved domains of genes critical to the proper function of the ETC or genes that have been implicated in human mitochondrial disease. This collection is designed to accelerate the use of zebrafish to study many different aspects of mitochondrial function to widen our understanding of their role in biology and human disease.
Preliminary Study of Enological Potential and Volatile Compounds of Tintilla de Rota Somatic Variant Grown in a Warm Climate
Authors: Lasanta Cristina , Amores-Arrocha Antonio , Caro Ildefonso , Sancho-Galán Pau
Published: July 2022

In an enological market notable for its use of universal varieties, the enological potential of the somatic variant Tintilla de Rota has been studied in a warm climate area from where it originates and has been compared with three universal cultivars and with a reference cultivar in Spain. It has been found that Tintilla de Rota is a grapevine cultivar that can adapt easily to the area where it has been grown traditionally, achieving adequate pH and acidity values while maintaining a moderate sugar content compared to the other varieties studied. Additionally, it has shown high anthocyanin content. In terms of aromatic composition, it has exhibited a content equal to or even higher than the other varieties analyzed in this study in most of the aromatic families studied, with a higher content of compounds such as 1-octanol, benzyl alcohol and citronellol, which can lead to wines with an interesting and distinguished aromatic profile. All these facts confirm the interest in the use of this cultivar and the importance of recovering and enhancing the value of autochthonous cultivars as opposed to other so-called universal varieties.
Elite Adolescent Ice Hockey Players: Analyzing Associations between Anthropometry, Fitness, and On-Ice Performance
Authors: Martini Gaëtan , Brunelle Jean-François , Lalande Vincent , Lemoyne Jean
Published: July 2022

In the field of ice hockey, body mass and height have always played a role in team selection. This study aims to analyze the associations between anthropometry and multiple dimensions of performance among elite adolescent ice hockey players. Methods: 187 adolescent players (males: n = 80, 13.81 years; females: n = 107, 14.96 years) took part in the study, in Camp 1. Off-ice fitness and on-ice skating tests were performed. Camp 2 consists of on-ice tests and match performance with players selected by coaching staff at Camp 1. Camp 2 data came from official matches performance and a combination of skating tests and intrasquad matches. Hockey Quebec’s selection process consists of going from an entire pool of athletes to a team of twenty-five players, through several camps spread over two years. Correlation analyses were conducted to verify associations between anthropometric measures and performances. Results: In Camp 1, heavier-taller male athletes displayed better performances in most off-ice fitness tests, while heavier female athletes tended to display poorer performance. Camp 2 showed no significant correlations in on-ice tests and match performance. However, some tendencies were observed: heavier male players were less involved in blocked shots, and taller females were more agile. Conclusions: Despite off-ice advantages, the taller-heavier prototype does not translate directly to better performance on the ice among elite adolescent players. Coaches should analyze anthropometric characteristics with caution, and place more focus on match-specific abilities to identify talent.
Effects of Leader Conscientiousness and Ethical Leadership on Employee Turnover Intention: The Mediating Role of Individual Ethical Climate and Emotional Exhaustion
Authors: Saleh Tajneen Affnaan , Sarwar Abdullah , Islam Md. Amirul , Mohiuddin Muhammad , Su Zhan
Published: July 2022

Employees working under conscientious leadership perceive their leaders as ethical leaders. This study investigates the conscientiousness of leaders as an essential trait of ethical leadership and the relationship between ethical leadership and employee-turnover intention. Additionally, we study the potential mediating roles of the individual-level ethical climate (self-interest, friendship, and personal morality) as well as the level of employees’ emotional exhaustion that contribute to the decision-making process of turnover intention. Building on social learning and social exchange theories, outcomes from nine industrial manufacturing organizations comprising 260 subordinates’ responses show that leaders’ conscientiousness is positively related to ethical leadership and negatively associated with employees’ turnover intention. Consistent with this hypotheses, results found that, in an individual-level ethical climate, employees experience diminished emotional exhaustion. The relationships are found to mediate between ethical leadership and turnover intention in manufacturing organizations. Additionally, it was also found that individual-level ethical climates cause a relatively positive impact on employees’ emotional exhaustion leading them to lower turnover intention.
Psychosocial Variables and Healthcare Resources in Patients with Fibromyalgia, Migraine and Comorbid Fibromyalgia and Migraine: A Cross-Sectional Study
Authors: Calandre Elena P. , García-Leiva Juan M. , Ordoñez-Carrasco Jorge L.
Published: July 2022

Fibromyalgia and migraine frequently coexist. We aimed to compare the burden caused by fibromyalgia (FM), migraine (M) and comorbid fibromyalgia and migraine (FM + M) by assessing psychosocial variables and the use of healthcare resources. A survey was posted to the websites of different patients’ associations. It included sociodemographic data, the Patient Health Questionnaire-9, the Insomnia Severity Index, the EuroQOL-5D-5L and a questionnaire evaluating the use of healthcare resources during the past six months. In total, 139 FM patients, 169 M patients and 148 FM + M patients participated in the survey. Mean depression and insomnia scores were clinically relevant in every group and significantly higher in FM + M (16.3 ± 5.4 for depression, 18.5 ± 5.6 for insomnia) than in FM (14.3 ± 5.7 for depression, 16.8 ± 5.5 for insomnia) or M (11.7 ± 5.4 for depression, 13.1 ± 5.9 for depression), where p < 0.001 in both cases. Suicidal ideation was frequent in every group, but significantly more frequent in FM + M (63% vs. 45% in FM and 35% in M; p < 0.001). EQ-5D-5L (0.656 ± 0.1 in FM + M, 0.674 ± 0.1 in FM, 0.827 ± 0.1 in M, p < 0.001) and EQ-5D-5L VAS scores (38.2 ± 21.9 in FM + M, 45.6 ± 21.8 in FM, 63.5 ± 23.7 in M, p < 0.00) were lower than the reported mean population values and the lowest in FM + M. FM and FM + M used more healthcare resources than M. It is concluded that the psychosocial burden was high in the three samples. FM and FM + M had a more relevant impact on patients’ wellbeing and required more medical attention than M. The burden caused by FM + M was higher than in both individual diseases.
Psychological Tasks Used in Neuroimaging with Male Perpetrators of Intimate Partner Violence against Women: A Systematic Review
Authors: Bueso-Izquierdo Natalia , Caro Cabeza Judit , Barbosa-Torres Carlos , Guerrero-Molina Mónica , Moreno-Manso Juan Manuel
Published: July 2022

This bibliographic review analyses the utility for psychologists of using neuroimaging tests and psychological or neuropsychological tests at the same time for studying the functioning of the brain in male abusers condemned for intimate partner violence against women (IPVAW). So as to be able to find an answer, we reviewed the available studies that investigated the structure or functioning of the brain. The results of these reviewed works of research show the benefits of using neuroimaging applied to male abusers, together with the use, either simultaneously or not, of other types of psychological, neuropsychological, or observational tests to complement and/or amplify the results of the neuroimaging techniques, as this can help us to advance in the knowledge of neuroscience as concerns the mind of the male abuser.
Control Violence Begins in Adolescent Dating: A Research from Students’ Perception
Authors: Lozano-Martínez Josefina , Castillo-Reche Irina Sherezade , Morales-Yago Francisco José , Ibáñez-López Francisco Javier
Published: July 2022

The purpose of this study was to analyze the prevalence of controlling violence experienced by adolescents in the Region of Murcia, as well as to analyze the patterns and sociodemographic variables involved such as sex, age, religious beliefs, sexual orientation, and country of origin of the families with the consequent cultural background provided. Using a sample of 454 secondary and high school students who completed a survey, the results revealed that 29.96% of the respondents were perpetrators (exerted violence) and 35.68% were victims of at least one dating abuse behavior. Significant differences were found in the occurrence of abuse based on family background, age, and religion. Finally, the results revealed that there were no significant differences in the victimization or perpetration of violence in relation to sex, but the older the victim, the less control exercised in cybernetic media, and the greater the control of the other in relation to family origin, where those from Latin American and African countries showed a greater propensity to control their partners than those of Spanish origin.
Ideal P2Y12 Inhibitor in Acute Coronary Syndrome: A Review and Current Status
Authors: Pradhan Akshyaya , Tiwari Aashish , Caminiti Giuseppe , Salimei Chiara , Muscoli Saverio , Sethi Rishi , Perrone Marco Alfonso
Published: July 2022

Dual antiplatelet therapy (DAPT) has remained the cornerstone for management of acute coronary syndrome (ACS) over the years. Clopidogrel has been the quintessential P2Y12 receptor (platelet receptor for Adenosine 5′ diphosphate) inhibitor for the past two decades. With the demonstration of unequivocal superior efficacy of prasugrel/ticagrelor over clopidogrel, guidelines now recommend these agents in priority over clopidogrel in current management of ACS. Cangrelor has revived the interest in injectable antiplatelet therapy too. Albeit the increased efficacy of these newer agents comes at the cost of increased bleeding and this becomes more of a concern when combined with aspirin. Which P2Y12i is superior over another has been intensely debated over last few years after the ISAR-REACT 5 study with inconclusive data. Three novel antiplatelet agents are already in the pipeline for ACS with all of them succeeding in phase II studies. The search for an ideal antiplatelet remains a need of the hour for optimal reduction of ischemic events in ACS.
Personalised Dosing Using the CURATE.AI Algorithm: Protocol for a Feasibility Study in Patients with Hypertension and Type II Diabetes Mellitus
Authors: Mukhopadhyay Amartya , Sumner Jennifer , Ling Lieng Hsi , Quek Raphael Hao Chong , Tan Andre Teck Huat , Teng Gim Gee , Seetharaman Santhosh Kumar , Gollamudi Satya Pavan Kumar , Ho Dean , Motani Mehul
Published: July 2022

Chronic diseases typically require long-term management through healthy lifestyle practices and pharmacological intervention. Although efficacious treatments exist, disease control is often sub-optimal leading to chronic disease-related sequela. Poor disease control can partially be explained by the ‘one size fits all’ pharmacological approach. Precision medicine aims to tailor treatments to the individual. CURATE.AI is a dosing optimisation platform that considers individual factors to improve the precision of drug therapies. CURATE.AI has been validated in other therapeutic areas, such as cancer, but has yet to be applied in chronic disease care. We will evaluate the CURATE.AI system through a single-arm feasibility study (n = 20 hypertensives and n = 20 type II diabetics). Dosing decisions will be based on CURATE.AI recommendations. We will prospectively collect clinical and qualitative data and report on the clinical effect, implementation challenges, and acceptability of using CURATE.AI. In addition, we will explore how to enhance the algorithm further using retrospective patient data. For example, the inclusion of other variables, the simultaneous optimisation of multiple drugs, and the incorporation of other artificial intelligence algorithms. Overall, this project aims to understand the feasibility of using CURATE.AI in clinical practice. Barriers and enablers to CURATE.AI will be identified to inform the system’s future development.
Effects of Acute Aquatic High-Intensity Intermittent Exercise on Blood Pressure and Arterial Stiffness in Postmenopausal Women with Different ACE Genotypes
Authors: Zhou Wen-Sheng , Yang Ai-Lun , Chen Chiao-Nan , Kan Nai-Wen , Kuo Joanna Ting-Hui , Chen Lee-Hwa , Chien Kuei-Yu
Published: July 2022

The present study investigated the effects of acute aquatic high-intensity intermittent jumping (HIIJ) on blood pressure (BP) and arterial stiffness in postmenopausal women with different angiotensin-converting enzyme genotypes (ACE). We recruited 12 postmenopausal women carrying the ACE deletion/deletion (DD) genotype and 61 carrying the insertion/insertion or insertion/deletion (II/ID) genotype. The participants performed 12 trials of 30 s, 75% heart rate reserve (HRR) jumping, and 60 s, 50% HRR recovery, and 3 trials of 40 s upper limb resistance exercises were performed as fast as possible. The heart rate (HR) and BP were measured before exercise, immediately, 10 min, and 45 min after exercise. The brachial-ankle pulse wave velocity (baPWV) was measured before and after exercise. The systolic blood pressure (SBP) of the DD genotype increased more significantly than those with the II/ID genotype post-exercise (30.8 ± 4.48 vs. 20.4 ± 2.00 mmHg, p = 0.038). The left and right sides of baPWV increased significantly after exercise (1444.8 ± 29.54 vs. 1473.4 ± 32.36 cm/s, p = 0.020; 1442.1 ± 30.34 vs. 1472.0 ± 33.09, p = 0.011), and there was no significant difference between the two groups. The HIIJ increased baPWV. The postmenopausal women with the DD genotype have a higher SBP increased post-exercise than those with II/ID genotype. These findings suggest that the aquatic exercise program has better effects in decreasing blood pressure in postmenopausal women with the II/ID genotype. Those with the DD genotype should pay attention to the risk of increasing blood pressure after aquatic HIIJ exercise.
Exploring the Linkages of Digital Food Communication and Analog Food Behavior: A Scoping Review
Authors: Bartelmeß Tina , Godemann Jasmin
Published: July 2022

The linkages of digital food communication on social media platforms and analog food behavior of social media users are widely discussed in media and research, but less differentiated. Due to the interdisciplinary nature of the research field, the scientific studies are characterized by great heterogeneity in approaching the role of communication and modelling of food behavior, and thus also the conclusions on how digital food communication might be linked to analog food behavior. There is still much uncertainty regarding the relationship and underlying assumptions between digital communication and analog action. The rationale of this scoping review is to systematically summarize the findings of this heterogeneous body of knowledge. The importance and originality of this review are that it focuses explicitly on studies that provide insights into the nexus of digital food communication and analog food behavior, be it in the theoretical foundation, the results, or their interpretation. It draws on a socio-ecological model of food behavior that depicts food behavior variables in different domains and uses a differentiated categorization of food behavior (food choice, dietary intake, and eating behavior) to synthesize the results. Using the Web of Science and PubMed databases, 267 abstracts were identified and screened, of which 20 articles met the inclusion criteria and were selected for full-text analysis. The review offers some important insights on how different variables of the socio-ecological model of food behavior are related to digital food communication and different areas of analog food behavior. This review provides a more discerning understanding of which aspects of analog food behavior may be linked to social media food communication and in which ways. Implications are derived to reflect the role of communication in previous models of food behavior by adding a more nuanced and cross-cutting understanding of food communication.
Intravascular Lithotripsy as a Novel Treatment Method for Calcified Unprotected Left Main Diseases—Comparison to Rotational Atherectomy—Short-Term Outcomes
Authors: Rola Piotr , Kulczycki Jan Jakub , Włodarczak Adrian , Barycki Mateusz , Włodarczak Szymon , Szudrowicz Marek , Furtan Łukasz , Jastrzębski Artur , Pęcherzewski Maciej , Lesiak Maciej , Doroszko Adrian
Published: July 2022

Background: The unprotected calcified Left Main disease represents a high-risk subset for percutaneous coronary intervention (PCI), and it is associated with a higher number of periprocedural complications and an increased rate of in-stent thrombosis and restenosis. Adequate lesion preparation plays a crucial role in achieving a favorable PCI outcome. Rotational Atherectomy (RA) is a well-established plaque-modifying method; nevertheless, the data regarding the effectiveness of RA in LM diseases is scarce. Recently, the novel ShockWave-Intravascular-Lithotripsy(S-IVL) device has been introduced to the PCI armamentarium in order to modify the calcified plaque. Methods: We performed a retrospective evaluation of 44 consecutive subjects who underwent the LM-PCI, and who were supported by either the RA or S-IVL. Results: The Rota group consisted of 29 patients with a mean syntax score of 28.0 ± 7.5. The S-IVL group was composed of 15 subjects with a syntax score of 23.3 ± 13.0 There were no statistical differences regarding MACE between the RA and Shockwave arms of the in-hospital group (10.3% vs. 6.7%), or in the six month (17.2% vs. 13.3%) follow-up group. Conclusions: RA and S-IVL could be safe and effective therapeutic strategies for calcified LM disease. Further studies with a higher number of participants and longer follow-up times are warranted to establish the potential benefits of RA and S-IVL for the management of LM stenosis.
Modification of the DIBR and MABAC Methods by Applying Rough Numbers and Its Application in Making Decisions
Authors: Tešić Duško , Radovanović Marko , Božanić Darko , Pamucar Dragan , Milić Aleksandar , Puška Adis
Published: July 2022

This study considers the problem of selecting an anti-tank missile system (ATMS). The mentioned problem is solved by applying a hybrid multi-criteria decision-making model (MCDM) based on two methods: the DIBR (Defining Interrelationships Between Ranked criteria) and the MABAC (Multi-Attributive Border Approximation area Comparison) methods. The methods are modified by applying rough numbers, which present a very suitable area for considering uncertainty following decision-making processes. The DIBR method is a young method with a simple mathematical apparatus which is based on defining the relation between ranked criteria, that is, adjacent criteria, reducing the number of comparisons. This method defines weight coefficients of criteria, based on the opinion of experts. The MABAC method is used to select the best alternative from the set of the offered ones, based on the distance of the criteria function of every observed alternative from the border approximate area. The paper has two main innovations. With the presented decision-making support model, the ATMS selection problem is raised to a higher level, which is based on a proven mathematical apparatus. In terms of methodology, the main innovation is successful application of the rough DIBR method, which has not been treated in this way in the literature so far. Additionally, an analysis of the literature related to the research problem as well as to the methods used is carried out. After the application of the model, the sensitivity analysis of the output results of the presented model to the change of the weight coefficients of criteria is performed, as well as the comparison of the results of the presented model with other methods. Finally, the proposed model is concluded to be stable and multi-criteria decision-making methods can be a reliable tool to help decision makers in the selection process. The presented model has the potential of being applied in other case studies as it has proven to be a good means for considering uncertainty.
Changes in Diversity and Structure of Thrips (Thysanoptera) Assemblages in the Spruce Forest Stands of High Tatra Mts. after a Windthrow Calamity
Authors: Masarovič Rudolf , Zvaríková Martina , Zvarík Milan , Majzlan Oto , Prokop Pavol , Fedor Peter
Published: July 2022

Strong winds, fire, and subsequent forest management impact arthropod communities. We monitored the diversity and changes in the community structure of forest thrips assemblages in the context of secondary succession and anthropogenic impact. There were eight study plots that were affected to varying degrees by the mentioned disturbances that were selected in the Central European spruce (Picea abies (L.) Karst.) forests in Slovakia. The soil photoeclectors were used to obtain thrips in the study plots during two vegetation seasons. The thrips assemblages and their attributes were analyzed by non-metric multidimensional scaling (NMDS). The significant changes in community structure, composition, stratification, species richness, and diversity of thrips assemblages that were caused by natural- (wind) and human-induced disturbance (forestry and fire) were observed in our research. Our analyses revealed a clear relationship between different thrips assemblages and impacted environment. Moreover, our results indicate that silvicolous thrips species may be useful for indicating changes and disturbances in forest ecological systems.
Shortcomings of Administrative Data to Derive Preventive Strategies for Inhospital Drug-Induced Acute Kidney Failure—Insights from Patient Record Analysis
Authors: Amelung Stefanie , Czock David , Thalheimer Markus , Hoppe-Tichy Torsten , Haefeli Walter E. , Seidling Hanna M.
Published: July 2022

Structured analyses of hospital administrative data may detect potentially preventable adverse drug events (ADE) and therefore are considered promising sources to prevent future harm and estimate cost savings. Whether results of these analyses indeed correspond to ADE that may be preventable in clinical routines needs to be verified. We exemplarily screened all adult inpatients admitted to a German University Hospital (n = 54,032) for International Classification of Diseases-10th revision (ICD-10) diagnoses coding for drug-induced kidney injury (AKI). In a retrospective chart review, we checked the coded adverse events (AE) for inhospital occurrence, causality to drug exposure, and preventability in all identified cases and calculated positive predictive values (ppv). We identified 69 inpatient cases of whom 41 cases (59.4%) experienced the AE in the hospital (ppv-range 0.43–0.80). Causality assessment revealed a rather likely causal relationship between AE and drug exposure in 11 cases (15.9, 11/69, ppv-range 0.17–0.22) whereby preventability measures could be postulated for seven cases (10.1%, 7/69). Focusing on drug-induced AKI, this study exemplarily underlines that ICD-10-code-based ADE prevention efforts are quite limited due to the small identification rate and its high proportion of primarily outpatient events. Furthermore, causality assessment revealed that cases are often too complex to benefit from generic prevention strategies. Thus, ICD-10-code-based calculations might overestimate patient harm and economic losses.
Signs and Symptoms of Temporomandibular Dysfunction and Radiographic Condylar Morphology in Patients with Idiopathic Condylar Resorption
Authors: Yu Yanfang , Wang Sijie , Wu Mengjie , Chen Xiaoyan , He Fuming
Published: July 2022

Background: Little is known about the clinical characteristics of idiopathic condylar resorption (ICR). The aim of this study was to examine the signs and symptoms of temporomandibular dysfunction (TMD) and evaluate the morphological characteristics of the condyles in patients with ICR. Methods: Sixty patients with ICR (41 in the bilateral ICR group and 19 in the unilateral ICR group) and forty-one healthy controls were examined. Signs and symptoms of TMD were described, and three-dimensional models of the condyles were measured and analyzed. Results: In total, 81.7% of ICR patients had self-reported symptoms and 78.3% of ICR patients had objective-found signs. The anteroposterior diameter, transverse diameter, height, maximal sectional area, volume of the condyles, axial angle, and the distance from the posterior point of the condyle to the Saggittal standard line were significantly smaller in the ICR condyles compared with the controls (p < 0.05). The condylar neck angle was significantly larger in the ICR condyles compared with the controls (p < 0.05). Conclusions: Most patients with ICR had signs and symptoms of TMD. The prevalence of clicking and opening–closing deviation was significantly different between the bilateral and the unilateral ICR groups. In patients with ICR, the size of the condyles decreased significantly; the condyles also rotated inward, moved forward, and inclined posteriorly.
Relationship between Preoperative Lower Back Pain and Severe Postoperative Pain after Gynecologic Laparoscopy: A Prospective Observational Study
Authors: Song Jae-Yen , Chae Minsuk , Lee Hyunjoon , Moon Young-Eun
Published: July 2022

We hypothesized that preoperative lower back pain (LBP) may be associated with the severity of postoperative pain after gynecologic laparoscopy. This prospective observational study aimed to investigate the association between preoperative LBP and postoperative pain. We assessed the intensity of LBP before surgery and the postoperative pain after surgery. The abilities of preoperative LBP intensity, age, body mass index, and anesthetic duration time to predict moderate-to-severe postoperative pain were measured using receiver operating characteristic analysis. The data of 148 patients were analyzed. Only preoperative LBP intensity showed a significant association with moderate-to-severe postoperative pain (area under the curve, 0.71; 95% confidence interval, 0.63–0.79; p < 0.001). Preoperative LBP rated three on a numeric rating scale (NRS) had the highest combined sensitivity (75.3%) and specificity (58.3%). Patients with LBP above NRS 3 had more severe postoperative pain than those who did not (pain score 5.3 ± 2.2 vs. 3.9 ± 1.9, p < 0.001), leading to more opioid requirement in the recovery room (48.5% vs. 27.5%, p = 0.014). Preoperative LBP intensity is a useful factor for identifying patients at risk for pain after gynecologic laparoscopy.
Biopsychosocial Illness Model: From the Lung to the Eye
Authors: Scarinci Fabio , Parravano Mariacristina , Patacchioli Francesca Romana
Published: July 2022

Studies on the impact of different pathologies on the quality of life have made the translation of multidisciplinary scientific knowledge into a unified model of biopsychosocial disease possible in which several important biological variables are integrated with psychological-functional and sociological variables [...]
Berth Allocation at Passenger Terminals Using Auctions
Authors: Giampouranis Dimitrios K. , Golias Mihalis , Theofanis Sotirios , Boile Maria
Published: July 2022

In this paper, we compare a multi-round, second-price, sealed-bid bundle auction and a single-item, sequential, second-price, sealed-bid auction for berth slot leasing for vessels (roll-on/roll-off passenger vessels and/or cruise ships) at a public marine terminal. The bundle auction mechanism is designed to maximize port operator profits by auctioning berth (time) slots in groups. The framework is tested using simulation by varying: the number of roll-on/roll-off passenger/cruise ship operating companies; the number of slots they bid for; and the mechanism design with regards to the winner determination, slot valuation, and max to min slot bid ratio among the bidders. The results indicate that neither auction type is a clear winner, and depending on the assumptions, a terminal operator should choose one over the other. The results from this study can be used by terminal operators, given their knowledge and/or assumptions on slot valuations and demand, to select a winner-determination policy and the minimum number of slots they allow players to bid for when designing the auction of their berth capacity to maximize their profits.
RNA-Seq Based Transcriptome Analysis of Aspergillus oryzae DSM 1863 Grown on Glucose, Acetate and an Aqueous Condensate from the Fast Pyrolysis of Wheat Straw
Authors: Kubisch Christin , Kövilein Aline , Aliyu Habibu , Ochsenreither Katrin
Published: July 2022

Due to its acetate content, the pyrolytic aqueous condensate (PAC) formed during the fast pyrolysis of wheat straw could provide an inexpensive substrate for microbial fermentation. However, PAC also contains several inhibitors that make its detoxification inevitable. In our study, we examined the transcriptional response of Aspergillus oryzae to cultivation on 20% detoxified PAC, pure acetate and glucose using RNA-seq analysis. Functional enrichment analysis of 3463 significantly differentially expressed (log2FC >2 & FDR < 0.05) genes revealed similar metabolic tendencies for both acetate and PAC, as upregulated genes in these cultures were mainly associated with ribosomes and RNA processing, whereas transmembrane transport was downregulated. Unsurprisingly, metabolic pathway analysis revealed that glycolysis/gluconeogenesis and starch and sucrose metabolism were upregulated for glucose, whereas glyoxylate and the tricarboxylic acid (TCA) cycle were important carbon utilization pathways for acetate and PAC, respectively. Moreover, genes involved in the biosynthesis of various amino acids such as arginine, serine, cysteine and tryptophan showed higher expression in the acetate-containing cultures. Direct comparison of the transcriptome profiles of acetate and PAC revealed that pyruvate metabolism was the only significantly different metabolic pathway and was overexpressed in the PAC cultures. Upregulated genes included those for methylglyoxal degradation and alcohol dehydrogenases, which thus represent potential targets for the further improvement of fungal PAC tolerance.