bluuebunny/crossref_metadata_2025 huggingface dataset:
How many words are Australian children hearing in the first year of life?
Authors: Brushe Mary E , Lynch John W. , Reilly Sheena , Melhuish Edward , Brinkman Sally A.
Published: January 2020

Background: There is evidence that parents from more socioeconomically disadvantaged backgrounds engage in fewer verbal interactions with their child than more advantaged parents. This leads to the so-called, ‘30 million-word gap’. We used improved technology to investigate the number of words children hear in their first year of life. Methods: Mothers were recruited into a five-year prospective cohort study and categorized into either high or low maternal education groups. Data was derived from the first two waves of the study, when the children were six and twelve months old. At both waves, children were involved in day-long audio recordings using the Language Environment Analysis software that provided automatic counts of adult words spoken to the child, child vocalizations and conversational turns. Descriptive results are presented by maternal education groups. Results: There was large variation within each maternal education group, with the number of adult words spoken to the child ranging from 2,958 to 39,583 at six months and 4,389 to 45,849 at twelve months. There were no meaningful differences between adult words, child vocalizations or conversational turns across maternal education groups at either wave of data collection. Conclusions: These results show that a word gap related to maternal education is not apparent up to twelve months of age. The large variability among both maternal education groups suggests that universal interventions that encourage all parents to talk more to their child may be more appropriate than interventions targeted towards disadvantaged families during the first year of life.
Putting RFMix and ADMIXTURE to the test in a complex admixed population
Authors: Uren Caitlin , Hoal Eileen G. , Möller Marlo
Published: January 2020

Background Global and local ancestry inference in admixed human populations can be performed using computational tools implementing distinct algorithms. The development and resulting accuracy of these tools has been tested largely on populations with relatively straightforward admixture histories but little is known about how well they perform in more complex admixture scenarios. Results Using simulations, we show that RFMix outperforms ADMIXTURE in determining global ancestry proportions even in a complex 5-way admixed population, in addition to assigning local ancestry with an accuracy of 89%. RFMix’s ability to determine global and local ancestry to a high degree of accuracy, particularly in admixed populations provides the opportunity for more accurate association analyses. Conclusion This study highlights the utility of the extension of computational tools to become more compatible to genetically structured populations, as well as the need to expand the sampling of diverse world-wide populations. This is particularly noteworthy as modern-day societies are becoming increasingly genetically complex and some genetic tools and commonly used ancestral populations are less appropriate. Based on these caveats and the results presented here, we suggest that RFMix be used for both global and local ancestry estimation in world-wide complex admixture scenarios particularly when including these estimates in association studies.
Prevalence of viral sexually transmitted infections and HPV high-risk genotypes in women in rural communities in the Department of La Paz, Bolivia
Authors: Patzi-Churqui Marianela , Terrazas-Aranda Katty , Liljeqvist Jan-Åke , Lindh Magnus , Eriksson Kristina
Published: January 2020

Background: Bolivia has the highest prevalence of cervical cancer in South America and the prevalence of viral sexually transmitted infections (STIs) among people in urban cities is increasing. Little is known about the prevalence of viral STIs in rural communities, which generally have limited access to health care. In order to study the prevalence of viral STIs in rural Bolivia, we recruited women from villages and towns in the Department of La Paz in Bolivia. Methods: 394 female participants were assessed for IgG-antibodies to herpes simplex virus type 2 (HSV-2), human immunodeficiency virus (HIV) and hepatitis B virus (HBV, anti-HBc), as well as for the presence of HBV surface antigen (HBsAg) in dried blood spots. The prevalence of 12 high-risk types of human papillomavirus (HPV) was assessed by qPCR in dried cervicovaginal cell spots from 376 of these women. χ 2 test was used to compare variables between the populations and binary logistic regression was used to identify risk factors associated with the positivity of the tests. Results: The seroprevalence of HSV-2 was 53% and of HBV 10.3%. HBAg was detected in 15.8% of women with anti-HBV antibodies indicating chronic infection. The frequency of high-risk HPV infection was 27%, with the most prevalent high-risk HPV types being HPV 56, 39 and 31 followed by HPV 16 and 18. Finally, none of the 394 women were seropositive for HIV, and about 64% of the studied population was positive for at least one of the viral infections. Conclusions: Women in Bolivian rural communities in La Paz show a high prevalence of HBV, HPV and, in particular, HSV-2. In contrast, none of the women were HIV positive, suggesting that the HIV prevalence in this population is low. The pattern of high-risk HPV types differed from many other countries with a predominance of HPV-types not included in the Gardasil vaccine which was officially introduced in Bolivia in April 2017. Key words : Prevalence, Sexually transmitted infections, women, La Paz, Bolivia, rural communities, HSV-2, HIV, high-risk HPV, HBV.
Musculoskeletal pain and work-related risk factors among waste collectors in Hanoi, Vietnam: A cross-sectional study
Authors: Nguyen Bang Van , Tran Thuy , Hoang Ngan Thi , Nguyen Bich Ngoc , Nguyen Quynh Thuy`
Published: January 2020

Background: Musculoskeletal disorders are prevalent among waste collectors in developing countries. This study aimed to investigate the prevalence of musculoskeletal disorders and risk factors of persistent musculoskeletal disorders among waste collectors in Hanoi, Vietnam. Methods: A cross-sectional survey was utilized to study 331 waste collectors in 2017. The Örebro Musculoskeletal Pain Questionnaire and questionnaires on demographic and work conditions were used to collect data. Descriptive and Linear regression analyses were applied at the significant level p<0.05. Findings: Results showed that the prevalence of musculoskeletal disorders among waste collectors participating into this study was high (100%), multiple-site musculoskeletal disorders (at least two sites) were reported by 81%. Lower back was the most affected site, followed by pain in the neck and shoulders. The risk of persistent musculoskeletal disorders were higher among female workers, workers with the neck bent at an angle of 450, kneeling, repetitive medial rotation while walking, and feeling dissatisfaction with work, stress or anxiety during one week before the survey. Conclusions: High prevalence of musculoskeletal disorders was observed among participated waste collectors and it associated with self-assessed unfavorable work postures and psychological stress at work. The findings imply the need of mechanical and social support at work for waste collectors to prevent the development of musculoskeletal disorders.
Assessment of seroepidemic conditions of hepatitis B virus among people under 29 years of age and evaluation of the hepatitis B vaccine after 22 years in Jiangsu Province, China
Authors: Sun xiang , Zhu Yuanyuan , Tang Fenyang , Hu Ying , Deng Xiuying , Wang Zhiguo , Liu Yuanbao , Zhou Minghao
Published: January 2020

Background This study aims to investigate the epidemiologic characteristics and variational trends following a hepatitis B vaccine (HepB) inoculation programme carried out in children over the last 22 years in Jiangsu province. It also aims to evaluate the effect of hepatitis B vaccine immunisation and to analyse the influential of HBsAg positive carriers. Finally, the study also provides reliable data and a baseline for adjusting future prevention and intervention strategies in Jiangsu province. Methods The incidence rates of hepatitis B virus (HBV) in Jiangsu province from 2004 to 2014 were obtained from the National Notifiable Disease Reporting System (NNDRS). A stratified cluster random sampling method was used to select 3,002 subjects aged 1-29 years across 13 hepatitis B virus monitoring points throughout the province, which had been classified as either urban or rural. HBV was assessed from venous blood samples using Abbott microparticle enzyme immunoassay (MEIA) kits (Abbott Laboratories, Chicago, Illinois). Results HBV incidence in the 1-29 age group showed a significant downward trend since 2004 (P<0.001). Serological assessments showed that the prevalence values of the hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (anti-HBc) in the 1-29 age group were 1.20% and 5.33%, respectively. And 66.89% tested positive for the hepatitis B surface antibody (anti-HBs). The HBsAg positive rate among participants was significantly lower in subjects who had been vaccinated than in those who had not (0.46% vs 14.93%, p<0.0001). Among persons who had received the full three-dose vaccine regimen, 90.93% received the first dose of the HBV vaccine within 24 hours of the baby’s birth. In this same group, the prevalence rates of HBsAg and anti-HBc were 0.05% and 0.95%, respectively, and the HBV infection rate decreased significantly after 2006. Conclusions The overall rate of Hepatitis B vaccinations and vaccinations administered within 24 hours of the baby’s birth have continuously improved since the HepB vaccine was integrated into the immunisation programme in Jiangsu province. Hepatitis B prevention and control works in the target population has achieved remarkable results.
Mobile device use and the cognitive function and depressive symptoms of older adults living in residential care homes
Authors: Lin Lu , Jing Xiuchen , Lv Shujiao , Liang Jinghong , Tian Li , Li Huiling , Puts Martine , Xu Yong
Published: January 2020

Background With the fast-paced aging and increasing digitalization of society, there has been a growing interest in the effect of mobile device use on cognitive function and depression in older adults. However, research examining this issue among older adults in residential care homes (RCHs) is scant. Therefore, this study aimed to examine the impact of mobile device use on the cognitive function and depressive symptoms of older adults living in RCHs.
Methods A cross-sectional survey was conducted using a sociodemographic questionnaire, the Montreal Cognitive Assessment (MoCA) and the 15-item Geriatric Depression Scale (GDS-15).
Results A total of 235 senior residents (aged 82.58 ± 5.54) in four RCHs were surveyed. Users of mobile devices had a significantly higher total MoCA score (25.02 ± 4.14) and a significantly lower GDS-15 score (3.28±2.74) than non-users (MoCA: 19.34 ± 5.21, GDS-15: 4.69±2.90). Multivariate linear regression indicate that mobile device use is significantly associated with total MoCA score, six of the seven sub-scores (visuospatial abilities and execution functions, attention, language, abstraction, delayed recall, and orientation)(P<0.05). Logistic regression showed that mobile device use was significantly associated with the level of depressive symptoms (OR=0.458, 95%CI=0.249-0.845).
Conclusions Use of mobile devices has a significant association with the cognitive function and depressive symptoms of older adults living in RCHs, and thus should be encouraged as a measure to maintain and improve cognition and prevent depression.
Comparison of Optical Quality and Distinct Macular Thickness in Femtosecond Laser-Assisted versus Phacoemulsification Cataract Surgery
Authors: Wang Yong , Zhang Jinling , Qin Miaomiao , Miao Jianguo , Chen Wei , Huang Yemeng , Wu Jian , Guan Yu , Guan Huaijin
Published: January 2020

Background: Optical quality and macular thickness changing optical quality is rarely reported after femtosecond laser-assisted cataract surgery (FLACS). In current research, we evaluated optical quality recovery and distinct macular thickness changes after FLACS and phacoemulsification cataract surgery (PCS).
Methods: A total of 100 cataract patients (100 eyes) were included (50 eyes for the FLACS group and 50 eyes for the PCS group). Modulation transfer function (MTF), point spread function (PSF) and dysfunctional lens index (DLI) were measured by a ray-tracing aberrometer (iTrace). Uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA) were also assessed pre-operation,1 week and 1 month after surgery. The MTF values at spatial frequencies of 5, 10, 15, 20, 25 and 30 cycles/degree (c/d) were selected. We used optical coherence tomography (OCT) to assess the macular thickness of different regions pre-operatively and1month after the surgery.
Results: In PCS group, we found the statistically significant differences between pre-operation and post-operation in DLI ( p <0.0001), PSF (strehl ratio, SR) ( p= 0.027) and MTF ( p =0.028), but not intraocular pressure (IOP) ( p =0.857). The differences between pre-operation and post-operation for DLI ( p =0.031), SR ( p =0.01) and IOP ( p =0.03), but not MTF ( p =0.128) were also found in FLACS group. The differences were statistically significant when the spatial frequencies were at 5, 10 and 25 ( p =0.013, 0.031 and 0.048) between pre-operation and post-operation in PCS group but not FLACS group at 1month. In PCS group, we found the differences between pre-operation and post-operation in nasal inter macular ring thickness (NIMRT) ( p =0.03), foveal volume (FV) ( p =0.034) and average retinal thickness (ART) ( p =0.025) but not FLACS group at 1month.
Conclusion: FLACS is safe that did not cause significant increase of macular thickness in current study. However, it also cannot produce better optical quality. In contrast, PCS can produce macular thickness changes, but better optical quality recovery. The slightly retinal change may not affect optical quality.
Characterization of genetic determinants of the resistance to phylloxera, Daktulosphaira vitifoliae, and the dagger nematode Xiphinema index from muscadine background
Authors: Rubio Bernadette , Lalanne-Tisné Guillaume , Voisin Roger , Tandonnet Jean-Pascal , Portier Ulysse , Ghelder Cyril Van , Lafargue Maria , Petit Jean-Pierre , Donnart Martine , Joubard Benjamin , Bert Pierre-Francois , Papura Daciana , Cunff Loïc Le , Ollat Nathalie , Esmenjaud Daniel
Published: January 2020

Background: Muscadine (Muscadinia rotundifolia) is known as a resistance source to many pests and diseases in grapevine. The genetics of its resistance to two major grapevine pests, the phylloxeraD. vitifoliaeand the dagger nematodeX. index, vector of theGrapevine fanleaf virus(GFLV) was investigated in a backcross progeny between the F1 resistant hybrid material VRH8771 (Muscadinia-Vitis) derived from the muscadine R source ‘NC184-4’ andV. viniferacv. ‘Cabernet-Sauvignon’ (CS).Results: In this pseudo-testcross, parental maps were constructed using simple-sequence repeats markers and single nucleotide polymorphism markers from a GBS approach. For the VRH8771 map, 2271 SNP and 135 SSR markers were assembled, resulting in 19 linkage groups (LG) and an average distance between markers of 0.98 cM. Phylloxera resistance was assessed by monitoring root nodosity number in anin plantaexperiment and larval development in a rootin vitroassay. Nematode resistance was studied using 10-12 month long tests for the selection of durable resistance and rating criteria based on nematode reproduction factor and gall index. A major QTL for phylloxera larval development, explaining more than 70% of the total variance and co-localizing with a QTL for nodosity number, was identified on LG 7. Additional QTLs were detected on LG 3 and LG 10, depending on thein plantaorin vitroexperiments, suggesting that various loci may influence or modulate nodosity formation and larval development. Using a Bulk Segregant Analysis approach and a proportion test, markers clustered in three regions on LG 9, LG 10 and LG 18 were shown to be associated to the nematode resistant phenotype. QTL analysis confirmed the results, although a LOD-score below the significant threshold value was obtained for the QTL on LG 18.Conclusions: Based on a high-resolution linkage map and a segregating grapevine backcross progeny, the first QTLs for resistance toDaktulosphaira vitifoliaeand toXiphinema indexwere identified from a muscadine source. All together these results open the way to the development of marker-assisted selection in grapevine rootstock breeding programs based on muscadine derived resistance to phylloxera and toX. indexin order to delay GFLV transmission.
Quality Use of Medicines in Patients With Chronic Kidney Disease
Authors: Castelino Ronald L , Saunder Timothy , Kitsos Alex , Peterson Greg , Jose Matthew , Wimmer Barbara , Khanam Masuma , Bezabhe Woldesellassie , Stankovich Jim , Radford Jan
Published: January 2020

Objective: To determine the extent of potentially inappropriate prescribing (PIP; defined as the use of a contraindicated medication or inappropriately high dose according to the kidney function) of renally-cleared medications commonly prescribed in Australian primary care, based on two measures of kidney function. A secondary aim was to assess agreement between the two measures.Design: Retrospective analysis of routinely collected de-identified Australian general practice patient data (NPS MedicineWise MedicineInsight from January 1, 2013, to June 1, 2016; collected from 329 general practices). Setting & Participants: All adults (aged ≥18 years) with chronic kidney disease (CKD) presenting to general practices across Australia.Results: A total of 48,731 patients met the Kidney Health Australia (KHA) definition for CKD and had prescriptions recorded within 90 days of measuring serum creatinine (SCr)/estimated glomerular filtration rate (eGFR). Overall, 28,729 patients were prescribed one or more of the 49 medications of interest. Approximately 35% (n=9,926) of these patients had at least one PIP based on either the Cockcroft-Gault (CG) equation or eGFR (CKD-EPI; CKD-Epidemiology Collaboration Equation). There was good agreement between CG and eGFR while determining the appropriateness of medications, with approximately 97% of the medications classified as appropriate by eGFR also being considered appropriate by the CG equation.Conclusion: This study highlights that PIP commonly occurs in primary care patients with CKD and the need for further research to understand why and how this can be minimised. The findings also show that the eGFR provides clinicians a potential alternative to the CG formula when estimating kidney function to guide drug appropriateness and dosing.
Dilatation of the Cystic Duct Confluence in Laparoscopic Common Bile Duct Exploration and stone extraction for Patients with Secondary Choledocholithiasis
Authors: Yang Xiao-Bin , Xu An-Shu , Li Jian-Gang , Xu Yong-Ping , Xu De-Song , Fu Chao-Chun , Deng Da-Bo , Li Jie , Zhang Ma-Zhong
Published: January 2020

The advent of endoscopic and laporoscopic techniques changed surgery in many regards. A number of options exist in the management of cholelithiasis and secondary choledocholithiasis. Among them, laparoscopic common bile duct (CBD) exploration with the choledocotomy followed by laparoscopic cholecystectomy (LC) has gained popularity. However, efforts should be made for minimally invasive or non-invasive to the CBD. For this purpose, we modified the surgical modality by laparoscopic transcystic approach with dilatation of the cystic duct confluence in CBD exploration (LTD-CBDE). The aim of this work was to assess the feasibility, safety and effectivity of LTD-CBDE based on our preliminary experience.
Evidence-based intrapartum practice and its associated factors at a tertiary teaching hospital in the Philippines, a descriptive mixed methods study.
Authors: Masuda Chisato , Ferolin Shirley Kristine , Masuda Ken , Smith Chris , Matsui Mitsuaki
Published: January 2020

Background Evidenced-based practice is one of the key components of quality care. However, previous studies have identified gaps between evidence and actual maternity practices in the Philippines. This study aims to describe practice of evidence-based intrapartum care and its associated factors, as well as exploring the perception of healthcare providers in a tertiary hospital in the Philippines. Methods A mix-methods study was conducted, which consisted of direct observation of intrapartum practices during the second and third stages; semi-structured interviews and focus group discussions with care providers to confirm the reasons to perform episiotomy or fundal pressure and their perception. Univariate and multivariate logistic regression were used to analyse the relationship between observed practices and maternal, neonatal and environmental factors. Qualitative data were extracted and categorised to identify themes related to the decision-making process of practices. Results A total of 170 deliveries were included. Recommended care, such as prophylactic use of oxytocin and controlled cord traction in the third stage, were applied in almost all the cases. However, harmful practices, such as intramuscular or intravenous oxytocin use in the second stage (14.1%) and lack of foetal heart rate monitoring (57.1%) were also observed. 92.0% of primiparas received episiotomy and 31.2% of all deliveries received fundal pressure. The following factors were associated with implementation of episiotomy; primipara (adjusted Odds Ratio [aOR] 62.3), duration of the second stage more than 30 minutes (aOR 4.6) and assisted vaginal delivery (aOR 15.0). Factors associated with fundal pressure were primipara (aOR 3.0), augmentation with oxytocin (aOR 3.3) and assisted vaginal delivery (aOR 4.8). Healthcare providers believe these practices can prevent laceration. Women who got obstetric anal sphincter injuries (OASIS) was 17.1% in this study. Assisted vaginal delivery (aOR 6.0), baby’s weight more than 3500g (aOR 7.8), episiotomy (aOR 26.4) and fundal pressure (aOR 6.2) were associated with OASIS. Conclusions Our study found potentially harmful practices were still conducted, contributing to the occurrence of OASIS. The perception of these practices was divergent with the current evidence, with empirical knowledge having more influence. Scientific evidence and its underlying basis should be understood among providers to improve practices.
Altered regional gray matter volume in Chinese female patients with bulimia nervosa
Authors: Li Xiao , Liu Xiaowei , Wang Yu , Li Lingfei , Zheng Linli , Liu Yaya , Ma Jing , Zhang Lan
Published: January 2020

Background The bulimia nervosa (BN) is one of the psychiatric disorders, which pathophysiology is not clear currently. Recent studies have concentrated on brain structural and functional changes in BN patients. However, findings have been inconsistent.The aim of this study was to explore the relationships between brain structural alterations and clinical features in Chinese female patients with BN. Method A total of 34 female patients with BN and 34 matched healthy controls (HC) underwent a T1-weighted magnetic resonance imaging (MRI) scanning. VBM analysis was carried out by using SPM8 ( http://www.fil.ion.ucl.ac.uk/spm/software/spm8/ ) to explore the alterations of regional Grey Matter Volume (GMV). The correlation analysis was performed using Statistical Package for the Social Sciences (SPSS) . Results The BN group showed reduced regional grey matter volume of the left medial superior frontal gyrus (SFGmed.L), the right superior temporal gyrus (STG.R), the right median cingulate and paracingulate gyri (DCG.R), the left median cingulate and paracingulate gyri (DCG.L) and the left dorsolateral superior frontal gyrus (SFGdor.L) compared to HC. There was no significantly regional grey matter volume increase in BN patients. The brain areas that GMV altered were uncorrelated with BMI and duration of illness (p>0.05). There was a significantly negtive correlation between age and GMV in the SFGmed.L (P<0.005, r=-0.516), the DCG.R (P<0.005, r=-0.556), the DCG.L (P<0.05, r=-0.576) and the SFGdor.L (P<0.005,r=-0.576). The self-esteem and self-evaluation of BN patients were uncorrelated with the structural alterations of GMV. Conlusions The results show altered regional GMV in females with bulimia nervosa in several brain areas, but it difficult to differentiate whether the GMV changes are the results of BN pathology or the consequences of binge-eating and compensatory behaviour. The structural alterations might be associated with impairments of inhibitory control and body dissatisfaction in BN patients, as well as mood disorder comorbidity.
Efficacy and experience of arthroscopic lateral patella retinaculum releasing through/outside synovial membrane for the treatment of lateral patellar compression syndrome
Authors: Chen Ji-Bin , Chen Dong , Xiao Ya-Ping , Chang Jian-Zhong , Li Te
Published: January 2020

Objective: To investigate the method and effect of arthroscopic lateral patella retinaculum releasing (LPRR) either through or outside synovial membrane for the treatment of lateral patellar compression syndrome (LPCS).Methods: From September 2014 to December 2017, 125 patients with LPCS underwent arthroscopic LPRR either through or outside synovial membrane combined with joint debridement. In the outside synovial membrane (OSM) group, synovial membrane was retained. In the through synovial membrane (TSM) group,The synovial membrane was cut open. Active rehabilitation training was conducted after surgery. Before and after surgery, Lysholm score, patella medial shift, Kujala score, VAS score and surgical complications were evaluated and compared.Results: All patients in this study were followed up for 1.5-5 years. All patients had significant reduction in knee pain and improved function after 1 month and 1 year. The Lysholm score, the distance of patella medial shift, the Kujala score, and the VAS score in the OSM group and the TSM group were significantly improved in the final follow-up compared with before surgery ( P <0.001), but these observed targets before surgery and at the last follow-up between the two groups were compared with no statistical differences. However, the number of occurrences of joint hematoma and adhesion was significantly higher in the TSM group than the OSM group ( P =0.024).Conclusion: Arthroscopic closing LPRR for the treatment of LPCS can effectively improve the function and symptoms of the patellofemoral joint with the advantages of small trauma, rapid recovery and less complications. But, the number of occurrences of hemarthrosis and joint adhesion in the TSM group were significantly higher than those in the OSM group.
Barriers for Full Immunization Coverage among under Five Years Children in  Mogadishu, Somalia
Authors: Mohamud Mohamed Hayir Tahlil , Mohamed Lul Mohamud , Magan Mohamed Ali , Mohamud Mohamed Abdulkadir , Muse Abdishakur Abdukadir
Published: January 2020

Background: Immunization is amongst the most cost effective public health interventions for reducing global childhood morbidity and mortality. However globally 9 million deaths of children occur as a result of vaccine-preventable disease, a bigger proportion occurred in sub-Saharan Africa which was 4.4 million. Therefore, this study aimed to assess barriers for complete vaccination coverage among under five years children in Mogadishu, Somalia. Methods: A community based Cross-sectional study was conducted in between April to July, 2019 in Mogadishu-Somalia. Two-stage cluster sampling with systematic random sampling was used to select a sample of 820 households. Data was collected through structured, interviewer administrator questionnaire. In case more eligible children found at single selected household, one child was randomly selected and the information related to immunization was interviewed from his/her caregiver. Results: the overall, fully vaccinated under five years children was found to be 45.2%. Immunization was found to be increased by being a younger caregiver (β = -0.019, P-value=0.042), being married caregiver, being Father with Secondary & above education (AOR=1.755, 95% CI=1.161-2.655, P-value =0.008), being a young child (β = -0.018, P-value=0.011), being children from birth order of fifth & above (AOR=1.539, 95% CI=1.011-2.343, P-value=0.044), Married caregiver (AOR=0.244, 95% CI= 0.063-0.94, P-value=0.041), increased Household monthly family income= (β = 0.003, P-value=0.000), Availability of vaccine at the time of visit (AOR =6.147, 95% CI=1.943-19.441, P-value=0.002), Cost affordability of vaccine =( AOR =1.951, 95% CI=1.238-3.076, P-value=0.004), Being born at health facility (AOR =1.517, 95% CI=1.104-2.086, P-value=0.010), having good Knowledge on immunization (AOR =1.125, 95% CI=1.070-1.181, P-value=0.001), having good Practice on immunization (AOR =2.756, 95% CI=2.233-3.402, P-value=0.001) and having good Perception on vaccine (AOR =4.976, 95% CI=2.183-11.340, P-value =0.001).Conclusion: In conclusion, the result of this study has revealed that the proportion of fully vaccinated under five children in Mogadishu is very low. Steps to promote Health education and vaccine availability should be lounged.
Effects of Combined Warmed Preoperative Forced-air and Warmed Perioperative Intravenous Fluids on Maternal Temperature During Cesarean Section: a prospective, randomized, controlled clinical trial
Authors: Ni tingting , Zhou Zhen-feng , He Bo , Zhou Qing-he
Published: January 2020

Background: Preventing the frequent perioperative hypothermia incidents that occur during elective caesarean deliveries would be beneficial. This trial aimed at evaluating the effect of preoperative forced-air warming alongside perioperative intravenous fluid warming in women undergoing cesarean sections under spinal anesthesia.Methods: We randomly allocated135 women undergoing elective cesarean deliveries to either the intervention group (preoperative forced-air and intravenous fluid warmings, n = 69) or the control group (no active warming, n = 66). The primary outcome measure was the change from the core baseline temperature to that at the end of the procedure. Secondary outcomes included thermal comfort scores, the incidences of shivering and hypothermia (<36℃), the core temperature on arrival at the post-anesthesia care unit, neonatal axillary temperature at birth, and Apgar scores.Results: Two-way repeated measures ANOVA revealed significantly different core temperature changes (from the pre-spinal temperature to that at the end of the procedure) between groups (F = 13.022, P <0.001). The thermal comfort scores were also higher in the intervention group than in the control group (F = 9.847, P = 0.002). The overall incidence of perioperative hypothermia was significantly lower in the intervention group than in the control group (20.6% vs. 51.6%, P <0.0001).Conclusions: Warming preoperative forced-air and perioperative intravenous fluids may prevent maternal hypothermia, reduce maternal shivering, and improve maternal thermal comfort for patients undergoing cesarean sections under spinal anesthesia.Trial registration: The study was registered with the Chinese Clinical Trial Registry (registration number: ChiCTR1800019117) on October26, 2018. Keywords: Cesarean section, Spinal anesthesia, Warming
Increased risk of sialolithiasis in smokers: A nested case-control study using a national health screening
Authors: Jin Young Ju , Han Young Eun , Choi Hyo Geun
Published: January 2020

ObjectivesThe purpose of this study was to evaluate the relationships among tobacco smoking, drinking alcohol, obesity and sialolithiasis in a Korean population.MethodsThe Korean National Health Insurance Service-Health Screening Cohort, which includes patients ≥ 40 years old, was assessed from 2002 to 2013. 947 sialolithiasis participants were matched with 3,788 control subjects at a ratio of 1:4 with respect to age group, sex, income group, region of residence, hypertension, diabetes, and dyslipidemia. We analyzed participants’ previous histories of smoking (current or past smokers compared to nonsmokers) and alcohol consumption (≥ 1 time per week compared to < 1 time per week) in the sialolithiasis and control groups. Obesity was measured using body mass index (BMI, kg/m2), which was categorized as < 18.5 (underweight), ≥ 18.5 and < 23 (normal), ≥ 23 and < 25 (overweight), ≥ 25 and < 30 (obese I), and ≥ 30 (obese II). Crude and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression analyses.ResultsThe rate of smoking was higher in the sialolithiasis group (32.4% [307/947]) than in the control group (29.1% [1,103/3,788], P = 0.047). The adjusted OR of smoking for sialolithiasis was 1.31 (95% CI = 1.08-1.59, P = 0.006). Alcohol consumption and obesity were not statistically significantly related to sialolithiasis.ConclusionThe odds of smoking were increased in sialolithiasis patients compared with the control subjects in ≥ 40 years old population.
Fingerfoods: a clustered-randomized feasibility study to enhance fruit and vegetable consumption in Dutch patients with dementia in a nursing home
Authors: Visscher Annemijn , Battjes-Fries Marieke CE , de Rest Ondine van , Patijn Olga N , Lee Mascha van der , Wijma-Idsinga Nienke , Pot Gerda K , Voshol Peter
Published: January 2020

Background Eating problems are highly prevalent in older patients with dementia and as a consequence, patients are at greater risk of becoming malnourished. Fingerfoods, snacks that can be picked with thumb and forefinger, could be used to counteract malnutrition in patients with dementia. The aim of this feasibility study was to evaluate whether providing fingerfoods as snacks was feasible for both patients with dementia and caregivers. Secondary objectives were to explore the effects of fingerfoods on total fruit and vegetable consumption, nutritional status and quality of life. MethodsInstitutionalised patients with dementia ( N = 22, 86% female, mean age = 85 years) were included in this clustered randomized controlled feasibility trial in the Netherlands. The intervention group ( N = 15) received their regular diet supplemented with fingerfoods, comprising quiches and cakes rich in fruit or vegetables, for 6 weeks. The control group ( N = 7) received their regular diet. Daily fingerfood consumption of patients and attitude of caregivers towards the fingerfoods were recorded to measure feasibility of the intervention. Fruit and vegetable consumption (3-day food records), nutritional status (body mass index (BMI) and SNAQ rc scores) and quality of life (QoL) (QUALIDEM) were measured in the first and last intervention week. The effects of fingerfoods on these outcomes were analysed with paired t-tests, Chi-square tests and ANCOVA. Results Patients consumed on average 70 grams of fingerfoods daily, containing 41 grams of fruit/vegetables. The intervention was rated as positive by 58% of the caregivers. Changes in fruit and vegetable consumption, malnutrition risk and QoL scores during the study period did not significantly change in the intervention group compared to the control group. Conclusion This feasibility study showed that providing fingerfoods to patients with dementia seems feasible for both patients and caregivers and could provide a pragmatic approach to enhance fruit and vegetable consumption in institutionalized elderly. In future research, long-term effects of fingerfoods should be studied on larger scale to confirm these findings. Trial Registration: Requested.
Cemented versus uncemented total hip arthroplasty for failed proximal femoral nail anti-rotation fixation in patients with intertrochanteric femur fractures: 5-year results of a retrospective observational study
Authors: Chen Wenli , Shuai Mao , Lin Jinluan , Chen Baomin , Zhao Mingdong , Zhang Chao Xin , Yu Weiguang , Han Guowei
Published: January 2020

Background: Cemented or uncemented total hip arthroplasty (CTHA or UTHA) is being increasingly performed in patients with intertrochanteric femur fractures (IFFs) who failed to be treated with proximal femoral nail anti-rotations (PFNA) fixation. The purpose of this study is to compare the clinical outcomes of CTHA or UTHA following prior failed PFNA fixation in patients with IFFs.Methods: Data from 244 patients with IFFs who underwent a conversion of PFNA to CTHA (PCA, n =120) or to UTHA (PUA, n = 124) due to pain and hip disfunction during 2008-2018 were retrospectively analysed. Follow-up occurred 1, 3, 6, and 12 months postoperatively and yearly thereafter. The mean follow-up was 64 months (range, 57 – 71 months). The Harris hip score (HHS) was the primary outcome; the incidence of major orthopaedic complications was the secondary outcome.Results: At the final follow-up, HHS was 79.54±18.85 vs 75.26±18.27 (PCA vs PUA, p = 0.014). There were significant differences between groups regarding the incidence of prosthesis revision, prosthesis loosening, and periprosthetic fracture (5.8% for PCA vs 14.5% for PUA, p = 0.025; 10.0% for PCA vs 20.1% for PUA, p = 0.027; 3.3% for PCA vs 10.5% for PUA, p = 0.028, respectively). Conclusion: The results of the study demonstrated a significant advantage with respect to HHS and major orthopaedic complication rate in favor of CTHA, as compared to UTHA in patients with a failed PFNA treatment.
Clinical efficacy of single intraoperative 500 mg methylprednisolone management therapy for thoracic myelopathy caused by ossification of the ligamentum flavum
Authors: Huo Xiaoyang , Zhou Jiaming , Liu Shiwei , Guo Xing , Xue Yuan
Published: January 2020

Background The objective of our study was to compare clinical outcome and postoperative complications between patients with thoracic myelopathy caused by ossification of the ligamentum flavum (OLF) treated with and without intraoperative methylprednisolone (MP).Methods This retrospective study enrolled 101 patients who underwent posterior approach surgery for OLF and were followed up at least 1 year. Patients were divided into two groups according to MP use in the operation: MP group (n=47) and non-MP group (n=54). Clinical outcomes and complications were evaluated before and after operation and at the last follow-up.Results Significant differences were found in modified Japanese Orthopedics Association (mJOA) scores and proportion of Frankel grade (A-C) between the two groups immediately after surgery and at 2-week follow-up. No significant differences were found between the two groups in mJOA score before operation and at the final follow-up. Moreover, no significant differences were observed in recovery rate according to mJOA score at any time points, and there were no significant differences in the proportion of Frankel grade between the two groups. There were 13 documented infections: 10 in the MP group and 3 in the non-MP group ( P =0.034).Conclusion Management therapy with intraoperative 500 mg methylprednisolone promoted the recovery of nerve function within 2 weeks in patients with thoracic myelopathy caused by OLF. However, long-term follow-up results showed that intraoperative methylprednisolone was inefficient. Moreover, intraoperative methylprednisolone increased the rate of wound infection.
A phase I study of a dual PI3-Kinase/mTOR inhibitor BEZ235 in adult patients with relapsed or refractory acute leukemia
Authors: Lang Fabian , Wunderle Lydia , Badura Susanne , Schleyer Eberhard , Brüggemann Monika , Serve Hubert , Schnittger Susanne , Gökbuget Nicola , Pfeifer Heike , Wagner Sebastian , Bug Gesine , Ottmann Oliver
Published: January 2020

Background Combined inhibition of phosphatidylinositol 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) complexes may be an efficient treatment for acute leukemia. The primary objective of this phase I single centre open lable study was to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of the dual pan-class I PI3K and mTOR inhibitor BEZ235 in patients with advanced leukemia.Methods Herein patients > 18 years of age who had relapsed or showed refractory leukemia were treated with BEZ235 (orally at 300-400 mg BID (cohort -1/1)) to assess safety, tolerability, preliminary efficacy and pharmakokinetic (PK). Adverse events data and serious adverse events were analyzed and haematological and clinical biochemistry toxicities were assessed from laboratory test parameters. Response was assessed for the first time at the end of cycle 1 (day 29) and after every subsequent cycle. Pharmacokinetic and pharmacodynamic analyses of BEZ235 were also included (BEZ235 plasma levels, phosphorylation of AKT, S6 and 4EBP1). On statistics this trial is a multiple ascending dose study in which a following variant of the 3+3 rule (“Rolling Six”), a minimum of 6 and a maximum of 12 patients was recruited for the dose escalation and another 5 were planned for the expansion phase. Results Twenty-four patients with ALL (n=11) or AML (n=12) or CML-BP (n=1) were enrolled. All patients had failed one (n=5) or more lines of therapy (n=5) and 14 patients were in refractory / refractory relapse. No formal MTD was defined, stomatitis and gastrointestinal toxicity at 400 mg BID dose was considered incompatible with prolonged treatment. The RP2D of BEZ235 was defined as 300 mg BID. Four of 24 patients showed clinical benefit. Twenty-two of 24 patients discontinued because of progression, (median time to progression 27 days (4d-112d). There was no association between PK parameters and efficacy or tolerability. Conclusions Combined inhibition of PI3K and mTOR inhibits a clinically meaningful driver pathway in a small subset of patients with ALL, with no benefit in patients with AML. Trial registration ClinicalTrials.gov, identifier NCT01756118. registered 19th Decembre 2012, https://clinicaltrials.gov/ct2/show/NCT01756118
Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine
Authors: Gross Elena C , Putananickal Niveditha , Orsini Anna-Lena , Vogt Deborah R. , Sandor Peter S. , Schoenen Jean , Fischer Dirk
Published: January 2020

Introduction Increasing evidence points towards the role of mitochondrial functioning, energy metabolism, and oxidative stress in migraine. However not all previous research has been conclusive and some mitochondrial function / oxidative stress markers have not yet been examined. Methods To this end, alpha-lipoic acid (ALA), total thiols, total plasma antioxidant capacity (TAC), lipid peroxide (PerOx), oxidised LDL (oxLDL), HbA1c and lactate were determined in the serum of 32 higher frequency episodic migraineurs (5-14 migraine days/ months, 19 with aura, 28 females) in this cross-sectional study. Results The majority of patients had abnormally low ALA and lactate levels (87.5% and 78.1%, respectively). 46.9% of the patients had abnormally high PerOx values, while for thiols and TAC over one third of patients had abnormally low values (31.2% and 37.5%, respectively). 21.9% of patients had abnormally low HbA1c and none had an HbA1c level above 5.6%. oxLDL was normal in all but one patient. Discussion This study provides further evidence for a role of oxidative stress and altered metabolism in migraine pathophysiology, which might represent a suitable therapeutic target. ALA, being too low in almost 90% of patients, might represent a potential biomarker for migraine. Further research is needed to replicate these results, in particular a comparison with a control group. This study is part of the trial registration: ClinicalTrials.gov: NCT03132233, registered on 27.04.2017, https://clinicaltrials.gov/ct2/show/NCT03132233
A member of wheat class III peroxidase gene family, named TaPRX-2A, enhanced the tolerance of salt stress
Authors: Su Peisen , Yan Jun , Li Wen , Wang Liang , Zhao Jinxiao , Ma Xin , Li Anfei , Wang Hongwei , Kong Lingrang
Published: January 2020

Background: Abiotic stresses including salt stress are environment stresses of limiting the crop growth and yield. It was reported that peroxidases (PRX) were involved in various abiotic stress responses. However, few wheat PRXs were characterized in the mechanism of abiotic stresses. Results: In this study, a novel wheat PRX gene named TaPRX-2A, a member of wheat class III peroxidase gene family, was cloned and characterized in salt stress response. According to the identification of class III PRXs in 12 different plants, we proposed an evolutionary model that this TaPRX-2A may have experienced some exon fusion events during evolution. The results of expression pattern showed that TaPRX-2A exhibited relatively high expression levels in root tissue, but low in stem and leaf tissues by using qRT-PCR. This TaPRX-2A was also induced by some stress and hormone treatments including PEG6000, NaCl, H 2 O 2 , SA, JA, and ABA. The result of overexpressing transgenic wheat showed that this TaPRX-2A enhanced the tolerance of salt comparing the wild-type wheat (WT). We also studied the molecular mechanism of TaPRX-2A mediating the salt stress response. Physiological experiments indicated that TaPRX-2A -overexpressing transgenic wheat possessed a higher survival rate, higher relative water content, and longer shoot length than WT, but remained the same in the root length under salt stress. Further experiments indicated that TaPRX-2A -overexpressing transgenic lines enhanced abiotic tolerance by enhancing oxidative stress tolerance, such as higher antioxidant activities of superoxide dismutase (SOD), peroxidase (POD) and catalase (CAT) enzymes, reduction of reactive oxygen species (ROS) accumulation, and lower levels of MDA content. Moreover, the transcript levels of stress-related genes were up-regulated by overexpression of TaPRX-2A. Conclusions: The results showed that TaPRX-2A play a positive factor in response to salt stress by scavenging ROS and regulating stress-related genes.