bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of groundwater potability and irrigation potential in Uttar Pradesh, India using water quality index and multivariate statistics
Authors: Chaudhary Supriya , Singh Gurudatta , Gupta Deepak , Singh Maunas Suruchi , Mishra Virendra Kumar
Published: March 2024

This study includes groundwater quality data from 290 monitoring sites from 69 districts of Uttar Pradesh, India. The analysis of the data showed that 98.97, 24.48, 52.07, and 68.97% of groundwater samples had concentrations of electrical conductivity (EC), total hardness (TH), Mg2+, and HCO3−, respectively, higher than the maximum permissible limit. Groundwater quality index (GWQI) was calculated for these 290 monitoring sites which revealed that 21 sites (7.24%) had inappropriate GWQI for drinking water, and 18 sites (6.21%) had an unsuitable index for irrigation. Most of the sampling sites (98.97%) showed high EC contents in groundwater with a mean value of 999.33 μS/cm. Fluoride content was found within the permissible limits in 95.52% of the samples, while 4.48% had high concentrations. The use of hierarchical cluster analysis differentiated all the sites into two clusters: one with high pollution and the other with low pollution. Significant correlations exist between physicochemical and irrigation indicators in the correlation matrix. High loadings of EC, TH, Ca2+, Mg2+, Na+, Cl−, and SO42− were identified in the first principal component, which are thought to be pollution-controlled processes from anthropogenic sources. According to the Chadha diagram, CaHCO3 and Ca–Mg–HCl were the two most prevalent chemicals in the water.
Hydrogeochemical characterization of groundwater in mountainous catchment and its suitability for drinking purposes in Irob, Tigray, Northern Ethiopia
Authors: Abadi Haile Tadelle , Alemayehu Tewodros , Berhe Berihu Abadi
Published: March 2024

The primary source of drinking water in Ethiopia's semi-arid mountainous regions is groundwater. The present study aims to assess the hydrogeochemical characteristics of low-grade basement rocks dominated by mountainous catchments. Moreover, it examines the suitability of the groundwater quality for drinking purposes in Irob, Tigray, northern Ethiopia. However, relatively little is known about the water chemistry and groundwater quality of the resources in the area. Fifteen samples of groundwater were collected and examined for ions according to standard procedures. The outcomes were assessed against the World Health Organization (WHO) drinking water quality criteria. To identify the source of dissolved ions and the process involved, graphic interpretations were applied. The results show that Ca–Mg–SO4–HCO3 and Ca–SO4–HCO3 were the dominant water types. Gibbs plots and ionic ratios reveal that silicate weathering, carbonate dissolution and ion exchange control water chemistry. Furthermore, the findings reveal that 60, 80, 46.67, 46.67, 60, 6.67, 60 and 53.33% of samples are above the safe limits of the WHO for hardness, alkalinity, total dissolved solids, electrical conductivity, calcium (Ca2+), potassium (K+), bicarbonate (HCO3-) and sulfate (SO42-), respectively. Consequently, the groundwater quality assessment demonstrates that the water sources in lower parts of the catchment are unsuitable for drinking.
Using unsupervised learning to classify inlet water for more stable design of water reuse in industrial parks
Authors: Chen Kan , Shi Xiaofei , Zhang Zhihao , Chen Shijun , Ma Ji , Zheng Tong , Alfonso Leonardo
Published: March 2024

The water reuse facilities of industrial parks face the challenge of managing a growing variety of wastewater sources as their inlet water. Typically, this clustering outcome is designed by engineers with extensive expertise. This paper presents an innovative application of unsupervised learning methods to classify inlet water in Chinese water reuse stations, aiming to reduce reliance on engineer experience. The concept of ‘water quality distance’ was incorporated into three unsupervised learning clustering algorithms (K-means, DBSCAN, and AGNES), which were validated through six case studies. Of the six cases, three were employed to illustrate the feasibility of the unsupervised learning clustering algorithm. The results indicated that the clustering algorithm exhibited greater stability and excellence compared to both artificial clustering and ChatGPT-based clustering. The remaining three cases were utilized to showcase the reliability of the three clustering algorithms. The findings revealed that the AGNES algorithm demonstrated superior potential application ability. The average purity in six cases of K-means, DBSCAN, and AGNES were 0.947, 0.852, and 0.955, respectively.
Primeras huellas de tortugas terrestres gigantes del Cretácico Inferior (Soria, España): Testudopodus iberiae, nov. icnogen. nov. icnoesp.
Authors: Fuentes-Vidarte Carolina , Meijide-Fuentes Manuel , Meijide-Fuentes Federico , Meijide-Calvo Manuel
Published: March 2024

En este trabajo se analizan las icnitas del yacimiento de “Valdelalosa III”, perteneciente a la subcuenca oriental de la Cuenca de Cameros (Cordillera Ibérica), Formación Huérteles, Berriasiense medio-superior (Cretácico basal), situado en los Valles de Valdelalosa, en el municipio de San Pedro Manrique (provincia de Soria, España). Las huellas de manos y pies son de diferente tamaño, tienen forma circular u ovalada y ocasionalmente marcan tres-cuatro uñas cortas y redondeadas. En el yacimiento se contabilizan 106 icnitas de las que 76 son huellas aisladas, 11 configuran un rastro, 15 son subhuellas y 4 son huellas parciales. En el rastro las impresiones de las extremidades del lado derecho del animal son paralelas a las del lado izquierdo y mantienen una distancia constante entre sí, carácter diagnóstico de los rastros de las tortugas. Las icnitas se han comparado morfológicamente y morfométricamente con otras icnitas de tortugas, con huellas de tortugas actuales, y con el pie y la mano de varios ejemplares de tortugas terrestres gigantes. Los resultados obtenidos de los análisis de las icnitas del yacimiento de “Valdelalosa III” permiten atribuirlas al paso de unas tortugas terrestres de gran tamaño y, debido a sus características se propone la creación del icnotaxon Testudopodus iberiae, nov. icnogen. nov icnosp.
Cumulative Exposure to Oxidized Low-density Lipoprotein is a Potential
Predictor for Prognosis in Acute Ischemic Stroke: A Cohort Study
Authors: Cheng Kaili , Chen Xiuqi , Luo Yufan , Sun Wenbo , Yang Xiaoli , Huang Shengwen , Wang Yuanyuan , Wu Danhong
Published: March 2024

Background:

Oxidized Low-Density Lipoprotein (ox-LDL) is crucial in the recrudescence and
prognosis of acute ischemic stroke (AIS). We aimed to probe into the influence of cumulative ox-LDL exposure
on the 90-day prognosis of AIS.

Methods:

Patients with AIS were recruited in this research. AIS severity at admission was estimated with infarct
volumes and National Institute of Health Stroke Scale (NIHSS) scores. AIS prognosis was assessed using
Modified Rankin Scale (mRS) scores at 90 days and the change in NIHSS scores from admission to discharge.
Cumulative ox-LDL exposure was defined as ox-LDL level (pg/mL) multiplied by age(y). Multivariate logistic
regression analysis was employed to reveal the correlation between exposure factors and the prognosis of
AIS. The prognostic prediction ability of cumulative ox-LDL exposure was compared with cumulative LDL
exposure by the receiver operating characteristic curve (ROC).

Results:

Higher cumulative ox-LDL exposure was related to worse prognosis, including neurological worsening
at discharge (NIHSS increasing more than 2 points) (OR = 3.02, 95% CI, 1.30-6.98, P = 0.01) and poor
functional prognosis at 90 days (mRS ≥ 3) (OR = 21.21, 95% CI, 4.72-95.36, P < 0.001). As multivariate regression
analysis showed, significantly increased cumulative ox-LDL exposure was relevant to poor functional
prognosis at 90 days (OR = 9.92, 95% CI, 1.23-79.76, P = 0.031), but not with neurological worsening at
discharge (P = 0.414). ROC curve revealed that cumulative ox-LDL exposure had a higher predictive value
(AUC = 0.843, P < 0.001) for functional prognosis of AIS than cumulative LDL exposure(AUC = 0.629, P =
0.023).

Conclusion:

Cumulative ox-LDL exposure has a positive correlation with poor prognosis at 90 days of AIS,
and has a more accurate predictive ability than cumulative LDL exposure.
The Application of Nanotechnological Therapeutic Platforms against
Gynecological Cancers
Authors: Keyvani Vahideh , Mollazadeh Samaneh , Riahi Espanta , Mahmoudian Reihaneh Alsadat , Tabari Masoomeh , Lagzian Elmira , Ghorbani Elnaz , Akbarzade Hamed , Gholami Amir-Sadra , Gataa Ibrahim Saeed , Hassanian Seyed Mahdi , Ferns Gordon A. , Khazaei Majid , Avan Amir , Anvari Kazem
Published: March 2024

Gynecological cancers (GCs), ovarian, cervical, and endometrial/uterine cancers, are often associated with poor outcomes. Despite the development of several therapeutic modalities against GCs, the effectiveness of the current therapeutic approaches is limited due to their side effects, low therapeutic index, short halflife, and resistance to therapy. To overcome these limitations, nano delivery-based approaches have been introduced with the potential of targeted delivery, reduced toxicity, controlled release, and improved bioavailability of various cargos. This review summarizes the application of different nanoplatforms, such as lipid-based, metal-based, and polymeric nanoparticles, to improve the chemo/radio treatments of GC. In the following work, the use of nanoformulated agents to fight GCs has been mentioned in various clinical trials. Although nanosystems have their own challenges, the knowledge highlighted in this article could provide deep insight into translations of NPs approaches to overcome GCs.
One-Pot Multicomponent Synthesis of Pyrano[2,3-c]pyrazole and 2-Amino-4Hbenzo[
b]pyrans Catalyzed by Hercynite@SiO2@Tris as Novel and Efficient
Nanocatalyst
Authors: Beiranvand Shima , Norouzi Masoomeh , Tahmasbi Bahman
Published: March 2024

In this study, magnetic hercynite nanoparticles (FeAl2O4, MNPs) were functionalized
by cheap and readily available tris(hydroxymethyl)aminomethane (Tris) as an organocatalyst.
Various techniques, including Vibrating Sample Magnetometry (VSM), Energy
Dispersive X-ray Spectroscopy (EDS), X-ray Diffraction (XRD), Scanning Electron Microscopy
(SEM), and Thermogravimetric Analysis (TG) were employed to determine the
morphology, particle size, physical properties, and magnetic properties of the nanoparticles.
Additionally, Fourier transform infrared spectroscopy (FT-IR) techniques were used to
investigate the presence of the functional group. The activity of this new catalyst as a magnetically
recoverable nanocatalyst was investigated in the synthesis of oxygen and nitrogencontaining
heterocyclic compounds. Pyranoprazole and 2-amino-4H-benzo[b]pyrans compounds
were synthesized with high efficiency in a short time. FeAl2O4@SiO2@Tris can be separated using
magnetic attraction and reused up to 5 consecutive times without a significant decrease in the yield of target
products or catalytic activity.
Synthesis, Molecular Docking, Anti-cholinesterase Activity, Theoretical Investigation,
and Catalytic Effect of New Encumbered N-benzyladamantyl Substituted
Imidazolidin-2-ylidene Carbene Pd-PEPPSI Complexes
Authors: Ikhlef Sofiane , Lasmari Sarra , Zendaoui Saber Mustapha , Mokrani El Hassen , Tebbani Dahmane , Gürbüz Nevin , Bensouici Chawki , Boulcina Raouf , Zouchoune Bachir , Özdemir Ismail
Published: March 2024

This study aimed to describe the preparation of novel PEPPSI type Pd(II)-NHC
complexes bearing N-benzyladamantyl substituted imidazolidin-2-ylidene group. All synthesized
compounds were characterized by using 1H-NMR and 13C-NMR spectroscopies,
FTIR, and elemental analysis techniques. One of the objectives of this study was the synthesis
of Pd-NHC complexes with AChE/BChE inhibition activities. Among all the tested
compounds, complexes 4b and 4c were found to have the most high potential AChE and
BChE inhibitory activities with IC50 values of 21.57 ± 0.23 Mm and 15.78 ± 0.39 Mm, respectively.
Conducting molecular docking studies helped us in gathering crucial information
about the main binding interactions of inhibitors and enzymes, and the results were
in agreement with the biological evaluation. The synthesized Pd-NHC complexes were
employed for catalyzing the direct C2- and C5-arylation reaction between aryl (hetero) halide and a variety of
heterocyclic systems. In both cases (C2 and C5-arylation), Pd-NHC complexes catalysts provided access to the
arylated heterocycles in good to high yields in the presence of 1 mol% catalyst loading at 150°C. The DFT theoretical
investigation showed that the Pd-NHC complexes were of ML2X2 type, where the the Pd(II) cation had
a square planar geometry. The interaction energies obtained by energy decomposition analysis (EDA) demonstrated
that the 4d and 4e complexes were more stable in the presence of more methyl substituents. The chemical
indicators demonstrated that the less stable 4c complex was more reactive in regard to the chemical hardness,
chemical potential, and electrophilicity values.
Cobalt(III)–porphyrin Complex as an Efficient and Recyclable Homogeneous
Catalyst for the Synthesis of Tetrahydro-2-oxa-4-thia-diazapentalen-5-one
Derivatives in Aqueous Medium
Authors: Abd El-Lateef Hany M. , Eskander Thomas Nady A. , Alzubi Mohammad Saleh Hussein , Khalaf Mai M. , Aleem Ali Ali El-Remaily Mahmoud Abd El
Published: March 2024

In this study, we successfully synthesized the CoPHrn complex as an efficient
and recyclable catalyst for the one-pot, three-component reaction of aromatic aldehydes,
2,4-thiazolidenedione, and hydroxylamine hydrochloride, leading to the synthesis of tetrahydro-
2-oxa-4-thia-diazapentalen-5-one derivatives under environmentally friendly conditions.
The structures of the newly formed compounds were determined through elemental
and spectral analyses. This methodology offers significant advantages, including its ecofriendliness,
cost-effectiveness, operational simplicity, extensive reusability, and applicability,
as well as the easy recovery of the catalyst using straightforward methods. Additionally,
a series of tetrahydro-2-oxa-4-thia-diazapentalen-5-one derivatives were successfully synthesized.
Notably, this novel procedure demonstrates remarkable benefits in terms of safety,
simplicity, stability, mild reaction conditions, short reaction times, excellent yields, and high purity, all achieved
without the use of hazardous solvents.
Feasibility of Point Shear Wave Elastography for Evaluating Renal Cortical
Thickness: A Prospective Study
Authors: Almutairi Fahad , Alyami Jaber
Published: March 2024

Background:

Chronic Kidney Disease [CKD] affects individuals of different age groups worldwide. Moreover, CKD is associated with several risk factors,
including obesity, lifestyle, and hypertension, which are common in the Middle East. Ultrasonography is the examination of choice for CKD. In
recent years, Shear Wave Elastography [SWE] has developed through the continued development of ultrasound and received substantial attention
;therefore, it can be used to measure tissue stiffness. The study aimed to use point Shear Wave Elastography [p-SWE] to determine the correlation
between diabetes and cortical renal thickness in detecting pathologies.

Methods:

This study was performed at the King Abdul-Aziz University Hospital. We examined 61 patients who underwent SWE. The patients were
classified into two groups based on the presence or absence of type 2 Diabetes Mellitus [DM].

Results:

The results showed that there was a significant correlation between cortical stiffness and DM duration [p<0.005]. In addition, there was a negative
correlation between cortical stiffness and cortical thickness [p=0.147] in patients with DM. Moreover, the eGFR decreased with an increase in
cortical stiffness [p=0.499]. The cortical thickness in patients with and without DM was 0.750 ± 0.2 kPa and 0.788 ± 0.4 kPa, respectively. The
kidney stiffness in patients with DM and control patients was 8.5 ± 8.6 cm and 14.0 ± 25.16 cm, respectively.

Conclusion:

This study showed that kidney p-SWE measurements were reliable. Therefore, further studies assessing kidney stiffness in patients with and
without people with diabetes are recommended.
Neuroinflammatory Response and Redox-regulation Activity of
Hyperoside in Manganese-induced Neurotoxicity Model of Wistar Rats
Authors: Ogunro Olalekan Bukunmi , Olasehinde Oluwaseun Ruth
Published: March 2024

Background:

Excessive manganese exposure can lead to neurotoxicity with detrimental
effects on the brain. Neuroinflammatory responses and redox regulation play pivotal
roles in this process. Exploring the impact of hyperoside in a Wistar rat model offers insights into
potential neuroprotective strategies against manganese-induced neurotoxicity.

Objective:

The study investigated the neuroprotective efficacy of hyperoside isolated from the
ethanol leaf extract of Gongronema latifolium (HELEGL), in the brain tissue of Wistar rats following
15 consecutive days of exposure to 30 mg/L of MnCl2.

Methods:

Control animals in Group 1 had access to regular drinking water, while animals in
groups 2–4 were exposed to MnCl2 in their drinking water. Groups 3 and 4 also received additional
HELEGL at doses of 100 mg/kg and 200 mg/kg of body weight, respectively. In Group 5,
HELEGL at a dose of 100 mg/kg of body weight was administered alone. Treatment with
HELEGL commenced on day 8 via oral administration.

Results:

HELEGL effectively mitigated MnCl2-induced memory impairment, organ-body
weight discrepancies, and fluid intake deficits. Exposure to MnCl2 increased the activities or levels
of various markers such as acyl peptide hydrolase, tumour necrosis factor-α, dipeptidyl peptidase
IV, nitric oxide, IL-1β, prolyl oligopeptidase, caspase-3, myeloperoxidase, H2O2, and
malondialdehyde, while it decreased the activities or levels of others, including AChE, BChE,
DOPA, serotonin, epinephrine, norepinephrine, GST, GPx, CAT, SOD, GSH, and T-SH (p <
0.05). In contrast, HELEGL effectively counteracted the adverse effects of MnCl2 by alleviating
oxidative stress, inflammation, apoptosis, mitochondrial dysfunction, cognitive deficits, and bolstering
the antioxidant status. Moreover, HELEGL restored the normal histoarchitecture of the
brain, which had been distorted by MnCl2.

Conclusion:

In summary, HELEGL reversed the causative factors of neurodegenerative diseases
induced by MnCl2 exposure, suggesting its potential for further exploration as a prospective
therapeutic agent in the management of Alzheimer's disease and related forms of dementia.
Boltzmann’s Theorem Revisited: Inaccurate Time-to-Action Clocks in
Affective Disorders
Authors: Ferber Sari Goldstein , Weller Aron , Soreq Hermona
Published: March 2024

Timely goal-oriented behavior is essential for survival and is shaped by experience. In this
paper, a multileveled approach was employed, ranging from the polymorphic level through thermodynamic
molecular, cellular, intracellular, extracellular, non-neuronal organelles and electrophysiological
waves, attesting for signal variability. By adopting Boltzmann’s theorem as a thermodynamic conceptualization
of brain work, we found deviations from excitation-inhibition balance and wave decoupling,
leading to wider signal variability in affective disorders compared to healthy individuals. Recent
evidence shows that the overriding on-off design of clock genes paces the accuracy of the multilevel
parallel sequencing clocks and that the accuracy of the time-to-action is more crucial for healthy behavioral
reactions than their rapidity or delays. In affective disorders, the multilevel clocks run free
and lack accuracy of responsivity to environmentally triggered time-to-action as the clock genes are
not able to rescue mitochondria organelles from oxidative stress to produce environmentally-triggered
energy that is required for the accurate time-to-action and maintenance of the thermodynamic equilibrium.
This maintenance, in turn, is dependent on clock gene transcription of electron transporters,
leading to higher signal variability and less signal accuracy in affective disorders. From a Boltzmannian
thermodynamic and energy-production perspective, the option of reversibility to a healthier time-toaction,
reducing entropy is implied. We employed logic gates to show deviations from healthy levelwise
communication and the reversed conditions through compensations implying the role of nonneural
cells and the extracellular matrix in return to excitation-inhibition balance and accuracy in the
time-to-action signaling.
Identificación de indicadores de gestión y su aplicación para la sostenibilidad de los centros comerciales en el Perú
Authors: Falconí Rodolfo Elias , Rivera Alegre Alexander
Published: March 2024

En el Perú toma cada vez más importancia la creación de centros comerciales como una alternativa a los mercados de abastos tradicionales o a las bodegas de barrio. Teniendo en consideración lo citado, este trabajo tiene por objetivos identificar y promover en el Perú la sostenibilidad de los centros comerciales a través de indicadores de gestión. Por tal motivo, se aplicaron técnicas de análisis sobre la base de encuestas que enfatizan, desde la perspectiva de los clientes, los atributos de los nuevos establecimientos, y la respectiva correlación de sus variables dependientes: tráfico y ventas. Los resultados muestran que la diferencia en las estrategias de mercadeo influye de manera significativa en el posicionamiento de los centros comerciales.
Improving the Prognostic Evaluation Precision of Hospital Outcomes for Heart Failure Using Admission Notes and Clinical Tabular Data: Multimodal Deep Learning Model
Authors: Gao Zhenyue , Liu Xiaoli , Kang Yu , Hu Pan , Zhang Xiu , Yan Wei , Yan Muyang , Yu Pengming , Zhang Qing , Xiao Wendong , Zhang Zhengbo
Published: March 2024

Background

Clinical notes contain contextualized information beyond structured data related to patients’ past and current health status.

Objective

This study aimed to design a multimodal deep learning approach to improve the evaluation precision of hospital outcomes for heart failure (HF) using admission clinical notes and easily collected tabular data.

Methods

Data for the development and validation of the multimodal model were retrospectively derived from 3 open-access US databases, including the Medical Information Mart for Intensive Care III v1.4 (MIMIC-III) and MIMIC-IV v1.0, collected from a teaching hospital from 2001 to 2019, and the eICU Collaborative Research Database v1.2, collected from 208 hospitals from 2014 to 2015. The study cohorts consisted of all patients with critical HF. The clinical notes, including chief complaint, history of present illness, physical examination, medical history, and admission medication, as well as clinical variables recorded in electronic health records, were analyzed. We developed a deep learning mortality prediction model for in-hospital patients, which underwent complete internal, prospective, and external evaluation. The Integrated Gradients and SHapley Additive exPlanations (SHAP) methods were used to analyze the importance of risk factors.

Results

The study included 9989 (16.4%) patients in the development set, 2497 (14.1%) patients in the internal validation set, 1896 (18.3%) in the prospective validation set, and 7432 (15%) patients in the external validation set. The area under the receiver operating characteristic curve of the models was 0.838 (95% CI 0.827-0.851), 0.849 (95% CI 0.841-0.856), and 0.767 (95% CI 0.762-0.772), for the internal, prospective, and external validation sets, respectively. The area under the receiver operating characteristic curve of the multimodal model outperformed that of the unimodal models in all test sets, and tabular data contributed to higher discrimination. The medical history and physical examination were more useful than other factors in early assessments.

Conclusions

The multimodal deep learning model for combining admission notes and clinical tabular data showed promising efficacy as a potentially novel method in evaluating the risk of mortality in patients with HF, providing more accurate and timely decision support.
Service Users’ Experiences of a Nationwide Digital Type 2 Diabetes Self-Management Intervention (Healthy Living): Qualitative Interview Study
Authors: Hawkes Rhiannon E , Benton Jack S , Cotterill Sarah , Sanders Caroline , French David P
Published: March 2024

Background

Diabetes Self-Management Education and Support programs for people living with type 2 diabetes mellitus (T2DM) can increase glycemic control and reduce the risk of developing T2DM-related complications. However, the recorded uptake of these programs is low. Digital self-management interventions have the potential to overcome barriers associated with attendance at face-to-face sessions. Healthy Living is an evidence-based digital self-management intervention for people living with T2DM, based on the Healthy Living for People with Type 2 Diabetes (HeLP-Diabetes) intervention, which demonstrated effectiveness in a randomized controlled trial. NHS England has commissioned Healthy Living for national rollout into routine care. Healthy Living consists of web-based structured education and Tools components to help service users self-manage their condition, including setting goals. However, key changes were implemented during the national rollout that contrasted with the trial, including a lack of facilitated access from a health care professional and the omission of a moderated online support forum.

Objective

This qualitative study aims to explore service users’ experiences of using Healthy Living early in the national rollout.

Methods

A total of 19 participants were interviewed via telephone or a videoconferencing platform. Topics included users’ experiences and views of website components, their understanding of the intervention content, and the overall acceptability of Healthy Living. Transcripts were analyzed thematically using a framework approach.

Results

Participants valued having trustworthy information that was easily accessible. The emotional management content resonated with the participants, prompting some to book an appointment with their general practitioners to discuss low mood. After completing the structured education, participants might have been encouraged to continue using the website if there was more interactivity (1) between the website and other resources and devices they were using for self-management, (2) with health professionals and services, and (3) with other people living with T2DM. There was consensus that the website was particularly useful for people who had been newly diagnosed with T2DM.

Conclusions

Digital Diabetes Self-Management Education and Support programs offering emotional aspects of self-management are addressing an unmet need. Primary care practices could consider offering Healthy Living to people as soon as they are diagnosed with T2DM. Participants suggested ways in which Healthy Living could increase interaction with the website to promote continued long-term use.
Long-Term Effectiveness of a Multi-Strategy Choice Architecture Intervention in Increasing Healthy Food Choices of High-School Students From Online Canteens (Click & Crunch High Schools): Cluster Randomized Controlled Trial (Preprint)
Authors: Delaney Tessa , Jackson Jacklyn , Lecathelinais Christophe , Clinton-McHarg Tara , Lamont Hannah , Yoong Sze Lin , Wolfenden Luke , Sutherland Rachel , Wyse Rebecca
Published: March 2024

BACKGROUND

School canteens are a recommended setting to influence adolescent nutrition due to their scope to improve student food choices. Online lunch ordering systems (“online canteens”) are increasingly used and represent attractive infrastructure to implement choice architecture interventions that nudge users toward healthier food choices. A recent cluster randomized controlled trial demonstrated the short-term effectiveness (2-month follow-up) of a choice architecture intervention to increase the healthiness of foods purchased by high school students from online canteens. However, there is little evidence regarding the long-term effectiveness of choice architecture interventions targeting adolescent food purchases, particularly those delivered online.

OBJECTIVE

This study aimed to determine the long-term effectiveness of a multi-strategy choice architecture intervention embedded within online canteen infrastructure in high schools at a 15-month follow-up.

METHODS

A cluster randomized controlled trial was undertaken with 1331 students (from 9 high schools) in New South Wales, Australia. Schools were randomized to receive the automated choice architecture intervention (including menu labeling, positioning, feedback, and prompting strategies) or the control (standard online ordering). The foods purchased were classified according to the New South Wales Healthy Canteen strategy as either “everyday,” “occasional,” or “should not be sold.” Primary outcomes were the average proportion of “everyday,” “occasional,” and “should not be sold” items purchased per student. Secondary outcomes were the mean energy, saturated fat, sugar, and sodium content of purchases. Outcomes were assessed using routine data collected by the online canteen.

RESULTS

From baseline to 15-month follow-up, on average, students in the intervention group ordered significantly more “everyday” items (+11.5%, 95% CI 7.3% to 15.6%; P<.001), and significantly fewer “occasional” (–5.4%, 95% CI –9.4% to –1.5%; P=.007) and “should not be sold” items (–6%, 95% CI –9.1% to –2.9%; P<.001), relative to controls. There were no between-group differences over time in the mean energy, saturated fat, sugar, or sodium content of lunch orders.

CONCLUSIONS

Given their longer-term effectiveness, choice architecture interventions delivered via online canteens may represent a promising option for policy makers to support healthy eating among high school students.

CLINICALTRIAL

Australian Clinical Trials ACTRN12620001338954, https://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=380546 ; Open Science Framework osf.io/h8zfr, https://osf.io/h8zfr/
Government-Nongovernmental Organization (NGO) Collaboration in Macao’s COVID-19 Vaccine Promotion: Social Media Case Study (Preprint)
Authors: Xian Xuechang , Neuwirth Rostam J , Chang Angela
Published: March 2024

BACKGROUND

The COVID-19 pandemic triggered unprecedented global vaccination efforts, with social media being a popular tool for vaccine promotion.

OBJECTIVE

This study probes into Macao’s COVID-19 vaccine communication dynamics, with a focus on the multifaceted impacts of government agendas on social media.

METHODS

We scrutinized 22,986 vaccine-related Facebook posts from January 2020 to August 2022 in Macao. Using automated content analysis and advanced statistical methods, we unveiled intricate agenda dynamics between government and nongovernment entities.

RESULTS

“Vaccine importance” and “COVID-19 risk” were the most prominent topics co-occurring in the overall vaccine communication. The government tended to emphasize “COVID-19 risk” and “vaccine effectiveness,” while regular users prioritized vaccine safety and distribution, indicating a discrepancy in these agendas. Nonetheless, the government has limited impact on regular users in the aspects of vaccine importance, accessibility, affordability, and trust in experts. The agendas of government and nongovernment users intertwined, illustrating complex interactions.

CONCLUSIONS

This study reveals the influence of government agendas on public discourse, impacting environmental awareness, public health education, and the social dynamics of inclusive communication during health crises. Inclusive strategies, accommodating public concerns, and involving diverse stakeholders are paramount for effective social media communication during health crises.
Examining Parent Mood, Feeding Context, and Feeding Goals as Predictors of Feeding Practices Used by Parents of Preschool Children With Avid Eating Behavior: Protocol for an Ecological Momentary Assessment Study (Preprint)
Authors: Edwards Katie , Croker Helen , Farrow Claire , Haycraft Emma , Herle Moritz , Llewellyn Clare , Pickard Abigail , Blissett Jacqueline
Published: March 2024

BACKGROUND

An avid eating behavior profile is characterized by a greater interest in food and a tendency to overeat in response to negative emotions. Parents use specific strategies to manage feeding interactions with children with avid eating behavior. While momentary and contextual factors, such as parental mood, have been found to influence parental feeding practices, there is a lack of research examining parents’ daily experiences of feeding children with avid eating behavior. Examining this is important because parental feeding practices are key levers in tailored interventions to support children’s healthy eating behavior.

OBJECTIVE

We aim to describe the ecological momentary assessment methods and procedures used in the APPETItE (Appetite in Preschoolers: Producing Evidence for Tailoring Interventions Effectively) project, which aims to examine how variation in parental mood, feeding goals, and the context of eating occasions affect the parental feeding practices used to manage feeding interactions with children with an avid eating behavior profile.

METHODS

Participants are primary caregivers from the APPETItE cohort who have a preschool-age child (aged 3-5 years) with an avid eating behavior profile. Caregivers complete a 10-day ecological momentary assessment period using signal- and event-contingent surveys to examine (1) mood and stress, (2) parental feeding goals, and (3) contextual factors as predictors of parental feeding practices.

RESULTS

Recruitment and data collection began in October 2023 and is expected to be completed by spring 2024. The data have a 3-level structure: repeated measurements (level 1) nested within days (level 2) nested within an individual (level 3). Thus, lag-dependent models will be conducted to test the main hypotheses.

CONCLUSIONS

The findings from this study will provide an understanding of caregivers’ daily experiences of feeding preschool children with avid eating behavior, who are at greater risk for the development of obesity. Understanding the predictors of feeding practices at the moment they occur, and across various contexts, will inform the development of tailored resources to support caregivers in managing children’s avid eating behavior.

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/55193
The Association of Cadence and the Weather Across Healthy Adults and Mobility Impaired Disease Groups (Preprint)
Authors: Long Mike
Published: March 2024

BACKGROUND

Real-world walking speed is being proposed as the sixth vital sign to track functional health; this requires consideration of how the context of activity affects the individual. For example, as it gets colder outside healthy adults walk faster and increase their cadence (steps/min). Environmental factors (weather conditions, time of year, time of day) and the individual (disease-group, gender, height, BMI) may have a varied impact on walking speed across disease cohorts.

OBJECTIVE

The aim of the paper is to examine the relationship between temperature and wind speed with measures of outdoor walking speed (cadence) across disease groups and healthy adult controls. Expected differences between disease groups and healthy controls were expected to be found.

METHODS

As a part of a technical validation study assessing worn mobility trackers (Mobilise-D), participants were asked to carry a smartphone with an installed tracking app recording GPS location, step activity and local temperature and wind speed, of walking bouts for seven consecutive days. A total of 57 participants were assessed included: 16 healthy adults, 12 patients with Multiple Sclerosis, 17 patients with Chronic Obstructive Pulmonary disease and 12 with Parkinson’s disease.

RESULTS

Pearson and Spearman Rank correlation coefficients were obtained for associations between hourly temperature and wind speed against hourly measurements of cadence and physical activity. Temperature and wind speed were found to be positively correlated with cadence (CI: -.437, -.228). Fisher’s r groupwise comparison established significant differences for associations of weather and mobility between health adults and COPD (p <.001), MS (p =.032), and PD (p = .007). The opposite effect of temperature on physical activity was observed in MS compared against COPD, PD and HA groups.

CONCLUSIONS

Mobility impaired disease groups are affected by the weather in a dissimilar pattern to that of healthy adults. This should be accounted for when measuring digital mobility outcomes of various patient groups. Smartphone apps for real world cadence appear to be very similar to those recorded by wearable sensors for both healthy adults and disease groups
Influence of TikTok on Body Satisfaction Among Generation Z in Indonesia: Mixed Methods Approach (Preprint)
Authors: Ariana Hanifa , Almuhtadi Ikmal , Natania Nikita Jacey , Handayani Putu Wuri , Bressan Stéphane , Larasati Pramitha Dwi
Published: March 2024

BACKGROUND

As social media platforms gain popularity, their usage is increasingly associated with cyberbullying and body shaming, causing devastating effects.

OBJECTIVE

This study aims to investigate the impact of social media on Generation Z users’ body image satisfaction. More specifically, it examines the impact of TikTok on body image satisfaction among TikTok users aged between 17 years and 26 years in Indonesia.

METHODS

The methodology used mixed-method approaches. Quantitative data were obtained from 507 responses to a questionnaire and analyzed using covariance-based structural equation modeling. Qualitative data were obtained from the interviews of 32 respondents and analyzed through content analysis.

RESULTS

This study reveals that upward appearance comparison is influenced by video-based activity and appearance motivation. Conversely, thin-ideal internalization is influenced by appearance motivation and social media literacy. Upward appearance comparisons and thin-ideal internalization comparisons detrimentally impact users’ body image satisfaction.

CONCLUSIONS

The results of this study are expected to provide valuable insights for social media providers, regulators, and educators in their endeavors to establish a positive and healthy social media environment for users.

CLINICALTRIAL
Enhancing Agency in Posttraumatic Stress Disorder Therapies Through Sensorimotor Technologies (Preprint)
Authors: Adrien Vladimir , Bosc Nicolas , Peccia Galletto Claire , Diot Thomas , Claverie Damien , Reggente Nicco , Trousselard Marion , Bui Eric , Baubet Thierry , Schoeller Félix
Published: March 2024

UNSTRUCTURED

Posttraumatic stress disorder (PTSD) is a significant public health concern, with only a third of patients recovering within a year of treatment. While PTSD often disrupts the sense of body ownership and sense of agency (SA), attention to the SA in trauma has been lacking. This perspective paper explores the loss of the SA in PTSD and its relevance in the development of symptoms. Trauma is viewed as a breakdown of the SA, related to a freeze response, with peritraumatic dissociation increasing the risk of PTSD. Drawing from embodied cognition, we propose an enactive perspective of PTSD, suggesting therapies that restore the SA through direct engagement with the body and environment. We discuss the potential of agency-based therapies and innovative technologies such as gesture sonification, which translates body movements into sounds to enhance the SA. Gesture sonification offers a screen-free, noninvasive approach that could complement existing trauma-focused therapies. We emphasize the need for interdisciplinary collaboration and clinical research to further explore these approaches in preventing and treating PTSD.
Development of Wick Editor-Based Learning Media that Emphasizes the Creative Thinking Ability
Authors: Muhammad Dhaffa  , Cahyono Hendarto , Azmi Rizal Dian
Published: March 2024

This development research aims to (1) Know the practicality of learning media based on the wick editor to be used in the learning process on the material of arithmetic rows and series (2) Know the response of students to the use of learning media in the classroom; and (3) Improve students' creative thinking skills to solve problems related to mathematics This research is a Research and Development (R&D) study with the ADDIE development model, namely Analysis, Design, Development, Implementation, and Evaluation. Data collection techniques used interviews, validation, student response questionnaires, and student creative thinking ability questionnaires. Validation was carried out by academics and practitioners, as well as students' responses. The wick editor-based learning media developed was tested on 34 students of class VIII at senior high school. The results of material expert validation obtained an average score of 82.95% with very valid criteria. The practicality of the media obtained from the student response questionnaire obtained an average score of 90% with very practical criteria. The effectiveness of the media is obtained from the average results of the questionnaire of students' thinking skills with an average N-Gain score of 0.75 with a high category.
HUBUNGAN KETERAMPILAN SOSIAL DAN JUVENIL DELIQUNCY KEPADA SISWA SEKOLAH MENENGAH PERTAMA DI KOTA BANDUNG
Authors: Annisa Dona Fitri , Supriatna Ecep
Published: March 2024

Masa remaja merupakan masa transisi, terdapat adanya kebingungan, kegelisahan, pertentangan,Â  dan konflik yang dialami dikarenakan pada fase ini remaja dalam masa kanak-kanak menuju dewasa. Pada fase ini, remaja membutuhkan untuk dapat memiliki keterampilan sosial sebagai upaya agar terhindar dari kenakalan remaja. Penelitian ini bertujuan untuk mengetahui hubungan keterampilan sosial dan Juvenile Delinquency remaja. Penelitian ini menggunakan metode penelitian deskriptif jenis korelasional. Alat pengumpulan data berupa angket dengan skala Likert. Jumlah sampel dalam penelitian ini sebanyak 334 orang. Teknik analisis data yang digunakan adalah statistik deskriptif dan pearson product moment correlation. Hasil penelitian menunjukkan bahwa terdapat hubungan yang signifikan dan negatif antara keterampilan sosial dan Juvenile Delinquency remaja di Kota Bandung dengan nilai rhitung yaitu -0,606 dengan sig 0,000 yang berada pada kategori cukup. Artinya, semakin tinggi keterampilan sosial remaja maka semakin rendah Juvenile Delinquency remaja.Â
Metabolic Fluxes in the Renal Cortex Are Dysregulated In Vivo in Response to High-Fat Diet
Authors: Hasenour Clinton M. , Banerjee Deveena R. , Young Jamey D.
Published: March 2024

Diabetes and obesity are risk factors for kidney disease. Whereas renal glucose production increases in diabetes, recent data suggest that gluconeogenic and oxidative capacity decline in kidney disease. Thus, metabolic dysregulation caused by diet-induced insulin resistance may sensitize the kidney for a loss in function. Here, we examined how diet-induced insulin resistance disrupts mitochondrial metabolic fluxes in the renal cortex in vivo. C57BL/6J mice were rendered insulin resistant through high-fat (HF) feeding; anaplerotic, cataplerotic, and oxidative metabolic fluxes in the cortex were quantified through 13C-isotope tracing during a hyperinsulinemic-euglycemic clamp. As expected, HF-fed mice exhibited increased body weight, gluconeogenesis, and systemic insulin resistance compared with chow-fed mice. Relative to the citric acid cycle, HF feeding increased metabolic flux through pyruvate carboxylation (anaplerosis) and phosphoenolpyruvate carboxykinase (cataplerosis) and decreased flux through the pyruvate dehydrogenase complex in the cortex. Furthermore, the relative flux from nonpyruvate sources of acetyl-CoA profoundly increased in the cortex of HF-fed mice, correlating with a marker of oxidative stress. The data demonstrate that HF feeding spares pyruvate from dehydrogenation at the expense of increasing cataplerosis, which may underpin renal gluconeogenesis during insulin resistance; the results also support the hypothesis that dysregulated oxidative metabolism in the kidney contributes to metabolic disease.

Article Highlights
Importancia del mantenimiento vehicular en el desarrollo de las empresas de transporte de carga pesada
Authors:   Instituto Superior Tecnológico Tungurahua Ecuador, Barreno Flores Charles Fabián , Mata Criollo Lilian Verónica ,   Instituto Superior Tecnológico Tungurahua Ecuador, Villacrés Padilla David Andrés ,   Instituto Superior Tecnológico Tungurahua Ecuador, Bonilla Parra Santiago Rodrigo ,   Instituto Superior Tecnológico Tungurahua Ecuador
Published: March 2024

El Sector del transporte de carga pesada a jugado un papel muy importante en el desarrollo de la economía del país, por lo que el mantenimiento de las diferentes unidades de carga es fundamental para garantizar el desarrollo y la comercialización de una gran variedad de productos, el transporte es una de las herramientas más indispensables para el desarrollo del comercio pues es un factor fundamental para la trasportación de bienes o productos a diferentes lugares del país, por lo que el principal objetivo de esta investigación es analizar la influencia de un correcto y constante mantenimiento vehicular en el desarrollo de las empresas dedicadas a la trasportación mediante fletes o encomiendas, para esta investigación se utilizó una metodología mixta en decir tanto cuantitativa como cualitativa, pues el control vehicular en este tipo de empresas es de suma importancia para el uso de los mismos, de esta manera se garantizará el ingreso en las empresas y se medirá mediante informes financieros el crecimiento de dichas empresas.
Andregjøring gjennom undervisningsmetoder: En blindsone i norsk skole?
Authors: Ramirez Carla , Kalkman Kris , Engan Laila
Published: March 2024

This chapter explores the way teaching methods and physical organization of classrooms in upper secondary schools in Norway result in Othering and marginalization of newly arrived non-Western students. Drawing on interviews with 49 ethnic minority students in four schools, this study reveals the agency of materiality in reproducing Othering processes. Guidelines from the Norwegian National Curriculum (Kunnskapsdepartementet, 2017) assert that didactical methods such as group work, group discussions and project work contribute to cooperative learning, increased reflection skills and student participation. In this study, analysis inspired by Barad’s (2007) posthumanism and Mignolo’s (2009)/Spivaks (1998) decolonial theory demonstrates how the physical organization in classrooms and the materiality of teaching methods are incorporated in an epistemology of modernity, individualism, and Western values. This European and continental backdrop of educational and pedagogical traditions is not necessarily understood by non-Western students with experiences from other worldviews and school systems.
ANALISIS STANDARISASI SARANA DAN PRASARANA LABORATORIUM BIOLOGI
Authors: A.H. Sari  , D. Safitri  , I. Haryati  , N. Anjalina  , E. Muliyah
Published: March 2024

Pembelajaran ilmu pengetahuan, khususnya biologi semakin menekankan perlunya mengintegrasikan kegiatan eksperimental melalui praktikum. Salah satu fasilitas untuk mendukung pembelajaran biologi di sekolah, terutama dalam pelaksanaan kegiatan praktikum adalah Laboratorium Biologi. Peran Laboratorium adalah sebagai pendukung proses pembelajaran untuk mencapai tujuan pembelajaran yang diinginkan. Oleh karena itu,harus memenuhi standar minimum terkait kelengkapan sarana dan alat sesuai dengan standar sarana dan prasarana. Penelitian ini bertujuan untuk mengetahui kesesuaian laboratorium Biologi di SMA Negeri 3 Tangerang Selatan dengan standar laboratorium yang tercantum dalam Permendiknas Nomor 24 Tahun 2007 tentang Standar Sarana dan Prasarana Pendidikan. Pengambilan data melalui observasi, wawancara dengan laboran dan guru biologi, serta dokumentasi. Data dianalisis secara deskriptif kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa sarana dan prasarana laboratorium biologi di SMAN 3 Tangerang Selatan sudah memenuhi standarisasi sesuai Permendiknas Nomor 24 Tahun 2007 dengan persentase 75,6% yang termasuk dalam kategori sangat lengkap.