bluuebunny/crossref_metadata_2025 huggingface dataset:
TYROSINEMIA TYPE III: A CASE REPORT OF SIBLINGS AND LITERATURE REVIEW
Authors: Barroso Fábio , Correia Joana , Bandeira Anabela , Carmona Carla , Vilarinho Laura , Almeida Manuela , Rocha Júlio César , Martins Esmeralda
Published: June 2020

ABSTRACT Objective: Tyrosinemia type III (HT III) is the rarest form of tyrosinemia, and the full clinical spectrum of this disorder is still unknown. The neurological involvement varies, including intellectual impairment and attention deficit disorder with hyperactivity (ADHD). We report the case of two siblings diagnosed with HT III at different ages. Case description: The index case was diagnosed by newborn screening for endocrine and metabolic disorders, starting a low-protein diet immediately, with a consistent decrease in tyrosine levels. By the age of three, the child displayed a hyperactive behavior, starting treatment for ADHD two years later. At seven years of age, he shows a slight improvement in terms of behavior and attention span and has a cognitive performance slightly lower than his peers, despite maintaining acceptable tyrosine levels. His sister, who had a history of ADHD since age five, was diagnosed with HT III after family screening at the age of eight. Despite initiating a dietetic treatment, her behavior did not improve, and she has a mild intellectual impairment. Comments: This is the first case report describing siblings with HT III who underwent nutritional treatment with a low-protein diet in different phases of life, with a better neurological and behavioral evaluation in the patient who started treatment earlier.
TREATMENT ADHERENCE AMONG CHILDREN AND ADOLESCENTS IN A CYSTIC FIBROSIS REFERENCE CENTER
Authors: Bonfim Bianca Sampaio , Melo Filho Valmir Machado de , Fontenelle Fernanda Matos , Souza Edna Lúcia
Published: June 2020

ABSTRACT Objective: To evaluate the level of self-referenced treatment adherence (TA) and its association with clinical and sociodemographic variables in patients with cystic fibrosis assisted at a reference center, as well as compare the level of self-referenced TA with that presumed by the multidisciplinary team. Methods: This is a cross-sectional study that included children and adolescents aged between 0-20 years with cystic fibrosis. Adolescents older than 14 years or their guardians, when younger than 14 years old, were interviewed using a standardized questionnaire. Professionals from the multidisciplinary clinic filled out another form with their impressions of the patients’ TA. Clinical and laboratory data were obtained in the medical records. The TA was considered satisfactory if the total adherence index (TAI) was equal or higher than 80%. Results: 53 patients were included with a median age of 112 months. The mean TAI was 83.2%. The mean TAIs for dornase alfa, pancreatic enzymes, continued use of inhaled tobramycin, vitamins supplements, nutritional supplements and dietary orientation was respectively: 86.1; 96.6; 78.6; 88.1; 51.8 and 78%. Children younger than 14 years presented better TA (p=0.021). The correlation between the self-referenced TA and the one presumed by the multidisciplinary team ranged from 0,117 to 0.402, being higher for Psychology and Nutrition professionals. Conclusions: The TAI was high particularly among children younger than 14 years. There was a positive correlation between the self-referenced TA and the one presumed by the Psychology (p=0.032) and the nutrition (p=0.012) professionals.
IRON DEFICIENCY ANEMIA AND ITS RELATIONSHIP WITH SOCIOECONOMIC VULNERABILITY
Authors: Rocha Élida Mara Braga , Lopes Amanda Forster , Pereira Silvia Maira , Leone Claudio , Abreu Luiz Carlos de , Vieira Patricia Dore , Szarfarc Sophia Cornbluth
Published: June 2020

ABSTRACT Objective: To analyze the association of anemia with the socioeconomic vulnerability of preschoolers in public day care centers, in the city of Taubaté, SP, Brazil. Methods: This is a cross-sectional study with a probabilistic sample that analyzed 363 children assisted in public day care centres in low-income and high-income areas of Taubaté, SP, Brazil. The hemoglobin concentration (Hb), dependent variable, was obtained by digital puncture, considering anemic children with Hb concentration <11.0 g/dL. The independent variables such as socioeconomic and demographic conditions were collected by a semi-structured questionnaire. Results: The prevalence of iron deficiency anemia was 19.3% among preschoolers. Children from day care centers with high socioeconomic vulnerability had lower Hb concentration than those from a non-vulnerable area (p<0.05). Conclusions: The lower concentration of hemoglobin in preschoolers is associated with the location of day care centers in an area of socioeconomic vulnerability. Children attending these day care centers face adverse family conditions such as low income, working mothers, and mothers with low schooling, though they receive social benefits and monitoring by public health services.
ORAL AND ENTERAL NUTRITION THERAPY IN INFLAMMATORY BOWEL DISEASES AMONG THE PEDIATRIC POPULATION: A LITERATURE REVIEW
Authors: Souza Gabriela Neves de , Draghi Patrícia Ferrante , Yonamine Glauce Hiromi
Published: June 2020

ABSTRACT Objectives: To review the literature on oral and enteral nutrition therapy and investigate the evidence of its efficacy as a treatment, as well as in preventing relapses and reducing symptoms of inflammatory bowel diseases in the pediatric population. Data source: We performed a bibliographic search in the PubMed, Web of Science, and Latin American and Caribbean Health Sciences Literature (Literatura Latino-Americana e do Caribe em Ciências da Saúde - Lilacs) databases, using the keywords “inflammatory bowel disease,” “diet,” and “diet therapy” in English and Portuguese, with filters for pediatric studies published in the previous five years. Data summary: We selected 16 articles for this study, nine on exclusive and/or partial enteral nutrition and seven on modified oral diets, such as the specific carbohydrate diet (SCD) and the Crohn’s Disease exclusion diet (CDED). The studies found evaluated the anthropometric profile of patients and the inflammatory profile of diseases in children before and after the introduction of each specific nutrition therapy. All interventions presented positive changes in these parameters; however, the results were inconclusive regarding the efficacy of SCD and CDED in the treatment and prevention of relapses. Conclusions: Exclusive enteral nutrition has proven to be effective in inducing remission of Crohn’s Disease, and the use of partial enteral nutrition for maintenance treatment has shown promising results. Other modified oral diets are inconclusive concerning their effectiveness, requiring further randomized controlled clinical trials.
Produção de discursos sobre a prevenção do HIV/Aids e da sífilis para gestantes em materiais educativos elaborados por instituições brasileiras (1995 - 2017)
Authors: Pontes Bianca Silva de , Santos Adriana Kelly , Monteiro Simone
Published: June 2020

Historicamente, as campanhas na mídia e materiais educativos para grupos diversos integram as ações de prevenção à Aids e outras infecções sexualmente transmissíveis (IST). Informado pelas críticas ao uso do Modelo Informacional de Comunicação presente nessas iniciativas, o artigo analisa 14 materiais sobre prevenção das IST/Aids voltados para gestantes, produzidos entre 1995-2017, no Brasil. Foram identificados elementos do contexto de produção (restrito e amplo) e foi examinado o dispositivo de enunciação dessas peças comunicacionais. Segundo os achados, os materiais reiteram a testagem no pré-natal como responsabilidade da mulher. São escassas as informações sobre uso do preservativo na gestação, o papel do parceiro na prevenção e a perspectiva da integralidade no cuidado à saúde. Conclui-se que, na comunicação para mulheres, é necessário contemplar os fatores socioculturais (classe social, cor/raça e normas de gênero) que condicionam a vulnerabilidade ao HIV/Aids e sífilis.
MultiSumm: Towards a Unified Model for Multi-Lingual Abstractive Summarization
Authors: Cao Yue , Wan Xiaojun , Yao Jinge , Yu Dian
Published: June 2020

Automatic text summarization aims at producing a shorter version of the input text that conveys the most important information. However, multi-lingual text summarization, where the goal is to process texts in multiple languages and output summaries in the corresponding languages with a single model, has been rarely studied. In this paper, we present MultiSumm, a novel multi-lingual model for abstractive summarization. The MultiSumm model uses the following training regime: (I) multi-lingual learning that contains language model training, auto-encoder training, translation and back-translation training, and (II) joint summary generation training. We conduct experiments on summarization datasets for five rich-resource languages: English, Chinese, French, Spanish, and German, as well as two low-resource languages: Bosnian and Croatian. Experimental results show that our proposed model significantly outperforms a multi-lingual baseline model. Specifically, our model achieves comparable or even better performance than models trained separately on each language. As an additional contribution, we construct the first summarization dataset for Bosnian and Croatian, containing 177,406 and 204,748 samples, respectively.
A Variational Point Process Model for Social Event Sequences
Authors: Pan Zhen , Huang Zhenya , Lian Defu , Chen Enhong
Published: June 2020

Many events occur in real-world and social networks. Events are related to the past and there are patterns in the evolution of event sequences. Understanding the patterns can help us better predict the type and arriving time of the next event. In the literature, both feature-based approaches and generative approaches are utilized to model the event sequence. Feature-based approaches extract a variety of features, and train a regression or classification model to make a prediction. Yet, their performance is dependent on the experience-based feature exaction. Generative approaches usually assume the evolution of events follow a stochastic point process (e.g., Poisson process or its complexer variants). However, the true distribution of events is never known and the performance depends on the design of stochastic process in practice. To solve the above challenges, in this paper, we present a novel probabilistic generative model for event sequences. The model is termed Variational Event Point Process (VEPP). Our model introduces variational auto-encoder to event sequence modeling that can better use the latent information and capture the distribution over inter-arrival time and types of event sequences. Experiments on real-world datasets prove effectiveness of our proposed model.
In situ automatic monitoring and working state assessment of inclined shafts in coal mines
Authors: Yan Qixiang , Li Binjia , Zhang Yanyang , He Chuan
Published: June 2020

The application of fabricated segmental lining in deeply buried inclined shafts in complex strata has been significantly increased in recent years. However, the structural safety of the fabricated lining is vulnerable to high ground stress and high water pressure, as well as the vibration of mechanical equipment and ground disturbance caused by coal mining. Thus, applying an automatic load-monitoring system to the inclined shaft in coal mines has great engineering importance in evaluating structural safety. In this study, an automatic monitoring and data transmission system for the inclined shaft was developed. In addition, by considering the non-linear characteristics of segment joints and different working states of concrete segments, a more functional assessment method was proposed based on the limit state assessment theory. According to the in situ monitoring project in the number 2 inclined shaft of Bulianta coal mine in China, the calculated internal forces are in good agreement with the monitored data, and the proposed assessment method shows reliable results during the operation period.
Enhanced dielectric properties of flexible Cu/polymer nanocomposite films
Authors: Atta Ali
Published: June 2020

This research studied the comprehensive dielectric properties of copper (Cu)/polyethylene terephthalate (PET) and copper/polytetrafluoroethylene (PTFE) composite films under the influence of copper nanoparticle (CuNP) sputtering time. Copper thin film was grown on flexible PET and PTFE using the ion beam sputtering technique. X-ray diffraction confirmed that CuNPs had been successfully synthesized on the polymer substrate. The electrical conductivity σ AC of the films was measured using alternating-current conductivity impedance in the frequency range of 102–106 Hz. It increased from 1.2 × 10−6 S/cm for PET to 9.65 × 10−7 S/cm for 75 min copper/PET and from 6.38 × 10−7 S/cm for PTFE to 9.24 × 10−7 S/cm for 75 min copper/PTFE. The dielectric constant ε′ increased from 0.62 for pristine PET to 1.19 for 25 min copper/PET and from 1.88 for pristine PTFE to 2.25 for 25 min copper/PTFE at an applied frequency of 105 Hz. In addition, other parameters – namely, dielectric loss ε″, dielectric modulus m and dielectric tangent constant tan δ – were investigated. The comprehensive results showed that the dielectric properties of flexible PET and PTFE polymers improved due to the deposited conductive CuNPs. Flexible copper/PET and copper/PTFE composite films are promising as dielectric substrates for modern electronic applications that can resist hard environments and have long lifetimes.
YÖNETİCİNİN KULLANDIĞI MOTİVASYONEL DİLİN ASTLARLA ETKİLEŞİM DÜZEYİNDEKİ ROLÜ: OTOMOTİV SEKTÖRÜNDE BİR ALAN ARAŞTIRMASI
Authors: AKDÖL Buket , ŞAHİN Serra Aybeniz
Published: June 2020

Yöneticilerin astlarıyla iletişim kurarken kullandıkları dil, astlarıyla geliştirdikleri ilişkide önemi yadsınamayacak etkiye sahip bir değişkendir. Sullivan 1988 yılında Motivasyonel Dil Teorisini geliştirmiş ve ardından gelen araştırmacılar yöneticilerin kullandıkları motivasyonel dilin performans ve iş tutumları gibi çeşitli çıktılarla ilişkisini irdelemişlerdir. Bu çalışmada da benzer şekilde yöneticilerin astlarıyla iletişimde kullandığı motivasyonel dilin, astlarıyla etkileşimlerinin niteliği üzerindeki rolünün araştırılması amaçlanmaktadır. Bu amaçla Mayfield, J., Mayfield, M ve Kopf, J. (1995) tarafından geliştirilen motivasyonel dil ölçeği ve Liden, R.C. ve Maslyn, J.M. (1998) tarafından geliştirilen lider üye etkileşimi ölçeği kullanılarak oluşturulan anket formu aracılığıyla Otomotiv Distribütörleri Derneği’ne üye olan otomotiv şirketlerinin beyaz yakalı çalışanlarından veri toplanmıştır. Araştırma sonucunda motivasyonel dilin tüm boyutlarının lider üye etkileşiminin tüm boyutlarıyla ilişkili olduğu ve motivasyonel dilin lider üye etkileşiminin kalitesine pozitif yönde ve anlamlı şekilde etki ettiği tespit edilmiştir.
SUBALTERNITY IN ARUNDHATI ROY’S THE GOD OF SMALL THINGS
Authors: OKUROĞLU ÖZÜN Şule , İREN Ayşe
Published: June 2020

Subaltern Studies, particularly in the field of social and cultural anthropology, has provided critical contexts that restore suppressed histories while criticizing Eurocentrism, imperialist biases, Enlightenment rationality, and the idea of nationalism. After the publication of Edward Said’s Orientalism, the terms subaltern and Subaltern Studies have become profoundly entangled with postmodern and postcolonial cultural studies, underlining the need for a conscious and deconstructivist approach for reading the history in order to get at the different ways in which European forms of knowledge represented the “subaltern”. Arundhati Roy’s famous novel The God of Small Things, while touching on many post-colonial issues ranging from linguistic imperialism to hybridity, is a striking display of the plight of subalterns. The subaltern in the novel can be grouped into three as “the inhabitants of Ayemenem”, “the untouchables” and “the women”. The novel scrutinises first colonial discourse and Western style of thinking about and studying the subaltern, and then how the colonizer and the colonized evolved within an unequal power relationship. Accordingly, this paper focuses on the ways in which hegemonic discourses constitute class, marginality and the objectification of the subaltern.
MEMLÛKLER DÖNEMİNDE MISIR’DA GAYRİMÜSLİMLERLE İLGİLİ YAŞANAN TOPLUMSAL HADİSELER VE ONLARA KARŞI UYGULANAN MÜEYYİDELER
Authors: EROL Burak Gani
Published: June 2020

Hz. Muhammed'in Medine'ye hicreti ile birlikte, İslâm toplumu içinde Müslüman olmayanların durumunun ne olacağı konusu ortaya çıkmıştır. O esnada Medine'de Müslümanların haricinde üç grup halinde yaşayan gayrimüslimler (Yahudiler, Hıristiyanlar ve Putperestler) ile Hz. Peygamber'in yaptığı antlaşma (Medine Vesikası) neticesinde bu sorun çözülmüş, İslam toplumu içerisinde yaşayan gayrimüslimlere bazı haklar tanınmıştır. Buna göre cihat sonucu İslâm devletinin egemenliğine giren tek tanrılı dinlere inanan topluluklar "zimmet" adı verilen bir anlaşma yahut kendilerine bahşedilen bir garanti sonucunda İslâm devleti tarafından korunmuşlardır. Dinlerini değiştirmeden İslâm Devleti tarafından korunan ve askerlikten muaf tutulan bu kişilere de zimmî denilmişti. Zimmî statüsündeki her şahsın malı, canı, vatandaşlık ve inanç hakları doğal ve tabii olarak vatandaşı olduğu devlet tarafından tıpkı Müslüman vatandaşınınkini koruduğu özen ve ihtimamla korunmaktaydı. 1250 senesinde son Eyyûbi sultanı Turanşah'ı öldürerek devletlerini kuran Memlûkler, 267 sene boyunca Mısır merkez olmak üzere tüm Orta Doğu'yu, Anadolu içlerinden, Nûbe’ye kadar, Hicaz bölgesi de dahil olmak üzere hakimiyet ve denetimleri altında tutmuşlardır. Memlûkler bu kadar geniş bir coğrafyada sadece topraklarında yaşayan Müslümanların değil aynı zamanda gayrimüslimlerin de efendileri ve sultanları olmuşlar, İslâm dininin yasalarını temel alan hukuk ve idare sistemi vasıtasıyla gayrimüslim teba ile de devlet-vatandaş ilişkisini tesis etmişlerdi. Lakin devletin 267 yıllık tarihi, bireysel hadiselere girilmeden dahi incelendiğinde devletin gayrimüslim tebası ile başta siyasî ve sosyal sebeplerden olmak üzere sorunlar yaşadığı ve sık sık onlara karşı müeyyideler uyguladığı göze çarpmaktadır. Genel olarak, gayrimüslimlerin İslam toplumu içinde yaşamalarından ve de İslam devletinde memur olarak istihdam edilmelerinden kaynaklı sorunlar çoğu zaman vazifelerinden azledilmeleri ile sonuçlanmıştı.
Malignant and premalignant lesions of the tongue, clinical and histopathological findings for their early detection. Study of two cases
Authors: Martinez-Martinez Adel , Diaz-Caballero Antonio , Quintero-Echenique Natalia
Published: June 2020

Background: Squamous cell carcinoma affects subjects between the sixth and seventh decade of life. However, there are growing reports on the involvement of young adults.

Clinical Cases: Two male patients aged 40 and 55, with no history of tobacco consumption and occasional alcohol consumption. They presented an exophytic ulcer and a white plaque on the lateral border of the tongue, the first diagnosed as moderately differentiated squamous cell carcinoma without HPV DNA genotypes and the second as leukoplakia without dysplasia.

Conclusions: Risk factors commonly associated with potentially malign disorders and oral cancer, such as smoking and alcohol consumption, were not involved in the present cases. Therefore identify clinical, histopathological and molecular findings, allows the early detection of them, improving the prognosis of these patients.
Síndrome de Klippel Trenaunay Weber en el embarazo. Reporte de caso y revisión de literatura
Authors: Paniagua-Coahuila Carlos Arturo , Martínez-Martínez Crescencio , Arellano-Hernández José Luis , Alonso-Lozano Dulce Alejandra , Mendoza-Hernández Freddy , Mendieta Zerón Hugo
Published: June 2020

Introducción: El síndrome de Klippel-Trenaunay (SKT) es un trastorno congénito que se caracteriza por la presencia de nevo cutáneo vascular, malformaciones venosas e hipertrofia de tejidos blandos y huesos que afectan una o más extremidades

Caso clínico: Una mujer de 20 años, primípara, diagnosticada con SKT desde la infancia, fue atendida a las 34 semanas de gestación con múltiples várices cervicales y vulvares y la presencia de un nevo vasculocutáneo en el miembro pélvico derecho; Se realizó angiorresonancia de contraste, donde se confirmaron múltiples malformaciones arteriovenosas a nivel de la extremidad pélvica derecha, comprometiendo la región inguinal, vulvar, femoral y discretamente el segmento uterino. El tratamiento con heparina de bajo peso molecular se inició hasta que se suspendió 24 horas antes de la programación de la cesárea a las 39,1 semanas de gestación.

Discusión: Se obtuvo un recién nacido sin complicaciones con sangrado transquirúrgico de 450 ml. Se fue a su casa 48 horas después de la cirugía sin evidencia de complicaciones y posterior seguimiento en una clínica ambulatoria de angiología y medicina crítica obstétrica.
KETERAMPILAN MENULIS DENGAN MODEL PAKEM MELALUI TEKNIK ‘MENJADI WARTAWAN JUNIOR’ DI SEKOLAH DASAR
Authors: Cahyani Isah , Hadianto D Daris
Published: June 2020

This research is motivated by the condition of students' writing abilities that are still low. One method that is considered appropriate is the PAKEM model by positioning students as junior journalists. The research method that I use is a quasi-experimental research method with a quantitative approach. The quantitative approach is used to obtain a picture of the ability of students to write reports on interviews through the technique of 'Becoming a Junior Reporter'. In addition, this study also uses a qualitative approach to describe the profile data of students' ability to write reports on the results of interviews through the technique of 'Becoming a Junior Journalist' before the learning approach to writing through the 'Becoming a Junior Journalist' technique is applied. The 'Become a Junior Journalist' technique is effective for improving students' ability to write reports based on an increase in the average pretest score of 57.47 to 78.50 on the average posttest score. Meanwhile, the final average value of the control class was 57.00 in the pretest and increased by 68.78 on the average posttest score. There was a difference in gain of 21.03 in the experimental group and 11.78 in the control group. This proves that writing ability can be improved with the PAKEM model through junior journalist techniques.
MEMBANGUN IDENTITAS BUDAYA BANYUMASAN MELALUI DIALEK NGAPAK DI MEDIA SOSIAL
Authors: Pawestri Ananda Galuh
Published: June 2020

Ngapak dialect is a cultural identity from Banyumasan area which includes Banjarnegara, Purbalingga, Banyumas, Cilacap, and Kebumen regency. The Ngapak dialect has a unique pronunciation that is assertive (luged) and without a doubt (ampang). This research explains how the ngapak dialect was chosen as a symbol of the Banyumasan’s cultural identity to interacting on social media. This research uses a qualitative method with a virtual ethnographic approach and also supported by the constructivism paradigm. The data was collected by observation, interviews, and documentation as the primary data and literature studies as the secondary data. The results of this research are ngapak dialect is the development of the perceptions of the stereotypes with the ngapak dialect that exist and the dialect of ngapak itself. The perception of the Banyumasan cultural community regarding the Ngapak dialect is unique, cool, and rich so don't be embarrassed and should be proud because Ngapak dialect has potential. Banyumasan cultural community uses dialect ngapak as content with comedy themes. The reflection of the comedy itself is the character of the Banyumasan folks called cablaka and mbanyol. Cablaka means pure and mbayol means silly or funny.
Clinical and genetic characteristics of congenital muscular dystrophies (Part 1)
Authors: Chausova P. A. , Ryzhkova O. P. , Polyakov A. V.
Published: June 2020

Congenital muscular dystrophy is an extremely heterogeneous group of hereditary neuromuscular diseases that are clinically characterized by muscular hypotonia, progressive muscle weakness, and dystrophic changes in the muscles. Overlapping clinical symptoms and many genes that have to be analyzed to determine the specific form of the disease in the patient make diagnosis difficult. The molecular genetic stage of diagnosis includes many different methods depending on the clinical hypothesis and their application has not lost its relevance even in the era of massive parallel sequencing. In addition to DNA sequence analysis, the analysis of muscle protein expression can also play a significant role in the diagnosis of congenital muscular dystrophy. In the review, we will consider the most important etiological, pathophysiological, clinical and laboratory data of the main forms of congenital muscular dystrophy known today.
Analysis of clinical manifestations and diagnosis of late-onset myasthenia gravis
Authors: Khalmurzina A. N. , Alekseeva T. M. , Lobzin S. V. , Rudenko D. I. , Kryuchkova V. V.
Published: June 2020

Introduction. Myasthenia gravis is one of the most common autoimmune neuromuscular diseases, the peak incidence is in the age of 20–40 years. However, studies show that throughout the world in recent decades there has been an increase in the prevalence and incidence of myasthenia gravis among older people.

Purpose of the study – to evaluate the clinical manifestations and diagnostic features of myasthenia gravis in patients with an onset of diseases in the elderly.

Materials and methods. The retrospective, non-interventional study included 315 patients over 18 years old with a reliable (3 out of 4 criteria) and an undoubted (4 out of 4 criteria) diagnosis of myasthenia gravis, the duration of the disease for up to 5 years, undergoing inpatient treatment from 2001 to 2017 years. The severity of the clinical manifestations of myasthenia gravis was assessed using the Myasthenia Gravis Foundation of America scale. We were taken into account the information about the first symptoms, duration of the period from the onset of the disease to the verification of the diagnosis, results of the examinations, the presence of concomitant diseases and treatment methods.

Results. The most common symptom of myasthenia gravis in the group of patients with debut disease aged 60 years and older was ptosis (p <0.001). The crises and pathology of the thymus were less common in elderly patients (p <0.0001). The concentration of antibodies to acetylcholine receptors was the same (p = 0.05) among all patients. The level of antibodies to titin was increased in patients with lateonset (p = 0.0014). The presence of bronchopulmonary pathology made worse the course of myasthenia gravis in elderly people (p = 0.01), while cardiovascular and cerebrovascular diseases, as well as diabetes mellitus, did not occur (p >0.005). At the first examination in the group of elderly patients among the incorrectly diagnoses prevailed: stroke or decompensation of chronic cerebral ischemia (p = 0.0002). With a comparable duration and severity of myasthenia gravis in different age groups, the combination of anticholinesterase drugs, glucocorticosteroids and azathioprine (p = 0.01) at a lower daily dose (100 mg) was more often used for the treatment of elderly patients compared with young and middle-aged groups (150 mg) (p = 0.03).

Conclusion. Diagnosis of myasthenia gravis in elderly patients presents the greatest difficulties, and symptoms of manifestation during initial treatment are often regarded as a manifestation of vascular pathology. Despite the presence of concomitant diseases characteristic of this age group, myasthenia gravis does not differ in the severity of the course. To achieve remission and compensation of symptoms, elderly patients do not need large doses of symptomatic and pathogenetic drugs.
Clinical and genetic characteristics of the early 66th type epileptic encephalopathy (literature review and own observation)
Authors: Markova T. V. , Borovikov A. O. , Lozier E. R. , Isaev A. A. , Kaimonov V. S. , Pomerantseva E. A. , Konovalov F. A. , Schagina O. A. , Dadali E. L.
Published: June 2020

Early epileptic encephalopathy-66 was first diagnosed in a male patient from Russia using whole-exome sequencing. Early epileptic encephalopathy- 66 is a unique disorder in the group of early epileptic encephalopathies. The same recurrent heterozygous variant of the nucleotide sequence was found in all known patients, but the severity of seizures and dysmorphic signs significantly vary between patients. The current study of a recurrent pathogenic variant in PACS2 gene expands the phenotype spectrum of early epileptic encephalopathy-66 and will improve the management of patients with that disorder in Russia in the future.
Experience of actovegin use in a patient with cognitive impairment in diabetes mellitus (clinical case)
Authors: Ovsyuk M. V.
Published: June 2020

Diabetic encephalopathy is one of the late complications of diabetes mellitus arising from chronic hyperglycemia and cerebral macro- and microangiopathy. Cognitive impairment developing during diabetic encephalopathy and the associated maladaptation of patients become even more socially significant due to the rapid increase in the number of patients suffering from diabetes mellitus. In this regard, studies of drugs that improve cognitive functions in patients with diabetes mellitus are of the particular importance. Clinical case of a patient with cognitive impairment and diabetes mellitus treated with actovegin describes its effect on glucose utilization, as well as antioxidant, antihypoxant and other mechanisms of action that allow the drug to be used in patients with cognitive impairment CI on the background of diabetes mellitus.
PRAYER AS A DIALOGUE BETWEEN PERSON AND GOD: THE RELIGIOUS ASPECT
Authors: Predko Olena
Published: June 2020

The author notes that prayer is a kind of mental state, which is characterized by extreme intensification of the emotional sphere, which ultimately leads to the transformation of a person, breakthrough into the sphere of the Divine. Moreover, the procedural nature of the prayer highlights the spiritual horizons of the being of a person, allows expanding its spiritual and transcendental meanings of existence. This would certainly contribute to the substantiation of the type of philosophizing that would combine the rational and the irrational and thereby serve both the mind, feeling and morality in the personality formation, its involvement in the sphere of the Divine. Prayer acts as a catalyst for the activity of the consciousness of the subject, his spirituality. It provides a person support for his target attitude, relieving internal stresses. Priority is its role in extreme situations when the maximum concentration of spiritual and physical forces of the person is required. Prayer practices act as a generator of energy, support the inner attitude of a person, necessary for further activities and for overcoming difficulties. In fact, the prayer becomes the generator of the formation of a kind of subjective reality of a person, sets its style of life and thinking. Prayer is the phenomenon by which not only certain meanings are found by person, but also indicators of the existence of a certain hierarchy of values and landmarks are verified. Spiritual prayer experience is the experience of human existence, the experience of "gathering oneself" from scattered parts, where a person is both an artist and a work of art, where not only one has to live, but also to comprehend, to create not only oneself in the process of this reflection, but also the world of the Other. Therefore, the prayer process forms the complex architectonics of the spiritual mode of being of a person, sets its viability, thanks to which it is self-determined, aiming at dialogue with the Absolute.
Pemanfaatan Ekstrak Buah Mangrove Untuk Menghambat Pembentukan Melanosis Pada Udang Vaname (Litopenaeus Vannamei)
Authors: Yuniarti Tatty , Sipahutar Yuliati , Ramli Husnul Khatimah , Nio Lita Noor Pitto Sari
Published: June 2020

Mangrove diketahui mempunyai kemampuan bioaktif untuk menghambat aktivitas enzim tirosinase. Penelitian bertujuan untuk menentukan konsentrasi ekstrak buah mangrove yang berperan dalam menghambat melanosis udang vaname selama penyimpanan 10 hari pada 0oC. Buah mangrove yang digunakan adalah Rhizophora mucronata, Rhizophora apiculata dan Avicennia marina. Buah mangrove diekstraksi menggunakan air. Konsentrasi ekstrak yang digunakan adalah 25% dan 50%. Udang disimpan selama 10 hari pada suhu 0oC menggunakan coldbox. Rancangan penelitian menggunakan Rancangan Acak Lengkap Faktorial (RALF). Parameter uji melanosis, organoleptik, warna dianalisis dengan ANOVA, dengan uji lanjut duncan. Parameter organoleptik dianalisis dengan uji non parametrik kruskal wallis, uji lanjut multiple comparison. Hasil penelitian menunjukkan udang yang direndam menggunakan ekstrak mangrove R. mucronata 50% dan R. apiculata 50% kemudian disimpan pada suhu 0oC mempunyai nilai melanosis terendah dibandingkan dengan ekstrak mangrove lainnya. Kenampakan organoleptik udang dapat dipertahankan dengan perendaman ekstrak R. mucronata 50% dan R. apiculata 50%, seluruh ekstrak tidak mempengaruhi bau khas dan tekstur udang vaname. Uji warna menunjukkan R. mucronata 25% mempunyai nilai L* tertinggi yang tidak berbeda nyata dengan R mucronata 50%. Nilai L* udang yang direndam A. marina 25% memiliki tingkat keefektifan terendah dalam mempertahankan nilai L*, seluruh jenis ekstrak, tidak mempengaruhi nilai a* dan b* warna udang. Ekstrak buah mangrove R. mucronata 50% dan R.apiculata efektif dalam menghambat melanosis udang.
Sintesis Biokoagulan Berbasis Kitosan Limbah Sisik Ikan Bandeng dan Aplikasinya Terhadap Nilai BOD dan COD Limbah Tahu di Kota Tarakan
Authors: Bija Stephanie , Yulma Yulma , Imra Imra , Aldian Aldian , Maulana Akbar , Rozi Anhar
Published: June 2020

Biokoagulan merupakan koagulan alami yang berperan untuk mengikat kotoran yang terdapatdi dalam limbah tahu. Sumber biokoagulan dapat berasal dari kitosan sisik ikan bandeng. Penelitian ini menentukan penurunan nilai BOD dan COD pada limbah tahu melalui biokoagulasi kitosan dari limbahsisik ikan bandeng. Metode yang digunakan dalam pembuatan kitosan melalui tahap deproteinasi (NaOH 0,1 N selama 2 jam pada suhu 65℃), demineralisasi (HCl 1 N selama 30 menit pada suhu ruang), dan deasetilasi (NaOH 20% selama 1 jam pada suhu 121℃). Karakteristik kitosan berupa derajat deasetilasi memiliki nilai 44%. Aplikasi kitosan sebagai biokoagulan dilakukan dengan prinsip koagulasi-flokulasi dengan penambahan larutan kitosan pada konsentrasi 10 ppm, 20 ppm, dan 30 ppm pada limbah tahu. Hasil penelitian menunjukkan adanya penurunan terhadap nilai BOD dan COD setelah penambahan kitosan 10 ppm, 20 ppm, dan 30 ppm. Perlakuan dengan penambahan kitosan 30 ppm merupakan perlakuan terbaik dengan nilai BOD yaitu 7 mg/L dan nilai COD yaitu 5600 mg/L.
Kinerja Membran Komposit Kitosan-Karagenan pada Sistem Microbial Fuel Cell dalam menghasilkan Biolistrik dari Limbah Pemindangan Ikan
Authors: Ibrahim Bustami , Uju  , Muhamad Soleh Agus
Published: June 2020

Microbial fuel cell (MFC) merupakan suatu teknologi yang memanfaatkan mikroba untuk mendegradasi bahan organik dan anorganik menjadi energi listrik, dapat dilakukan menggunakan sistem satu bejana atau dua bejana. Sistem MFC dua bejana menggunakan membran penukar proton yang berfungsi untuk mengalirkan proton yang dihasilkan dari ruang anoda ke ruang katoda, salah satu alternatif membran yang digunakan yaitu komposit kitosan-karagenan. Penelitian ini bertujuan untuk menentukan perbandingan komposit kitosan-karagenan sebagai membran penukar proton pada MFC, menentukan kinerja MFC dalam menghasilkan elektrisitas, serta menentukan kinerja penurunan beban polutan limbah cair pada MFC. Nilai elektrisitas MFC diukur menggunakan multimeter dengan parameter yang diuji adalah tegangan listrik, serta arus listrik. Parameter uji yang digunakan untuk mengukur penurunan beban polutan limbah cair adalah chemical oxygen demand (COD), biologycal oxygen demand (BOD) dan total amonia nitrogen (TAN). Membran komposit kitosan-karagenan dibuat dengan perlakuan perbedaan komposisi kitosan dan karagenan 1:1; 1,5:1; 3:1 (v/v). Perbedaan rasio kitosan dan karagenan pada membran komposit kitosan-karagenan memberikan pengaruh terhadap sifat mekanik membran, nilai elektrisitas MFC, serta beban polutan cair pada MFC. Membran komposit kitosan-karagenan dengan perbandingan 1:1 menghasilkan nilai konduktivitas proton tertinggi sebesar 1,15x10-3 S/cm, kuat tarik tertinggi 7,047 MPa, tegangan listrik 0,97 V, arus 7,02 mA, serta daya listrik 6,84 mW. Nilai COD, BOD, serta TAN limbah cair pemindangan ikan mengalami penurunan sebesar 90%, 76% dan 32%.
Evaluasi Periode Pemberian Pakan mengandung Daun Kayu Manis Cinnamomum burmannii terhadap Kualitas Daging Ikan Nila Oreochromis niloticus
Authors: Retno Palupi Triana , Setiawati Mia , Jusadi Dedi , Ahmad Fauzi Ichsan , Wasjan
Published: June 2020

Tekstur dan aroma menjadi salah satu indikator kualitas filet ikan nila untuk diekspor. Salah satu upaya untuk meningkatkan kualitas filet ikan dapat dilakukan dengan pemberian tepung daun kayu manis pada pakan. Penelitian ini bertujuan untuk menentukan periode waktu pemberian tepung daun kayu manis (DKM) yang dapat meningkatkan kualitas daging dan pertumbuhan ikan nila. Dosis tepung daun kayu manis yang diberikan pada adalah 1%. Pakan diberikan selama 15 hari (15D), 30 hari (30D), 45 hari (45D) dan 60 hari (60D) sebelum panen. Pemeliharaan ikan dilakukan menggunakan 20 hapa berukuran 2x1x1,5 m3 dengan padat tebar 20 ekor ikan/hapa, bobot ikan 30,23±0,15 g/ekor dan panjang 11-13 cm/ekor. Hasil penelitian menunjukkan bahwa pemberian tepung DKM mampu meningkatkan kualitas tekstur daging ikan nila dengan perlakuan terbaik pada 30D dengan nilai 547,5±9,1 gf. Uji kinerja pertumbuhan bobot dan retensi protein perlakuan 60D memberikan nilai yang berbeda nyata dibanding kontrol dengan nilai 3.854,3±219,0 g dan 44,0±6,3%. Nilai glikogen hati menunjukkan semua perlakuan memberikan nilai yang berbeda nyata dibanding kontrol dengan nilai berturut-turut 0,33±0,01, 0,35±0,01, 0,35±0,00,dan 0,35±0,00 (mg g-1). Nutrien berupa protein, lemak dan kadar air paling baik ditunjukkan pada perlakuan 60D dengan nilai masing-masing 18,8±0,7%, 1,85±0,14%, dan 76,6±0,9%. Berdasarkan hasil penelitian, dapat disimpulkan bahwa pemberian pakan mengandung daun kayu manis selama periode waktu 30 hari memberikan kualitas kekerasan daging ikan paling tinggi.
Effect of kangaroo mother care in terms of hospital stay among preterm infants in a tertiary health care center
Authors: E. Adarsh , D. B. Bindu Shri , G. Sahana
Published: June 2020

Background: Hypothermia, infections and ineffective breastfeeding are some of the commonest cause of deaths among premature and low birth weight infants. Kangaroo mother care is a well-known intervention to address the issues related to preterm births, such as hypothermia, infection and prolonged hospitalisation.Methods: This study was carried out in a tertiary care centre in Bengaluru on all preterm neonates of birth weight less than 2500 grams with stable hemodynamic conditions over a period of 18 months. Gestational age assessed by the new Ballard's score, within 24 hours of life and anthropometry details of the neonate were recorded at 24 hours of life by the single observer. Kangaroo mother care was given for a minimum of one hour at a stretch per day and the effect on the preterm neonate in terms of hospital stay was assessed.Results: Kangaroo mother care has positive effects on the infants growth, neurodevelopmental outcome, reduction in the morbidities associated with preterm infants, and breastfeeding practices in mothers of preterm neonates.Conclusions: The study promotes awareness of KMC on preterm neonates considering all the benefits and positive effects of KMC on the infant as well as baby, and to the family and nation amongst the health care personnel as well as the society.
Knowledge and awareness among nursing students regarding the COVID-19: a cross sectional study
Authors: Joshi K. P. , Madhura Leena , Jamadar Deepak
Published: June 2020

Background: The health care providers are at the front line of the outbreak response of current pandemic of COVID-19 and exposed to hazards that put them at risk of infection. Rapid spread of the COVID-19 pandemic has become a major cause of concern for the healthcare profession in all over the world. All health care professional must stay aware of the latest information on the COVID-19 outbreak. This research paper deals with the knowledge and awareness about COVID-19 among nursing students.Methods: By non-probability snowball sampling method the sample size was 407. Predesigned and pretested questionnaire was used in this study. Questions were related to knowledge and awareness about current COVID-19. The participant was directed to complete the self-report survey by online. The data was tabulated and analysed statistically. MS-Excel and Statistical Package for Social Sciences version 22.0 used for all statistical analysis.Results: A total of 407 nursing students participated in this study. Over all 75.58±3.21 participants showed good knowledge and awareness about COVID-19. Around 87.47% respondents were aware about high risk age group for COVID-19. 83.54% participants were aware about concept of hand hygiene and 83.37% were well aware of PPE for suspected or confirmed COVID-19 cases.Conclusions: The study participants showed adequate basic knowledge and awareness of COVID-19. There is a strong need to implement periodic educational interventions and training programs on infection control practices and other updates of COVID-19 across all healthcare professions including nursing students.
Effect of barbecue role and Gufoni maneuvers on quality of life in patients with horizontal semicircular canal benign paroxysmal positional vertigo
Authors: Sharma Kumar Gourav , Gupta Ashok Kumar
Published: June 2020

Background: Benign paroxysmal positional vertigo (BPPV) is the most common cause in patients with vertigo. Horizontal semi-circular canal BPPV (HSCBPPV) is up to 20% of BPPV. Quality of life (QoL) is significantly impaired by vertigo. Aim of present research was to study the effect and compare barbecue role and Gufoni maneuvers on QoL in patients with HSCBPPV.

Methods: 60 individuals with unilateral HSCBPPV were selected. 2 groups barbecue role and Gufoni were formed and 30 individuals were selected in each group randomly. Vestibular activities and participation (VAP) and positional test were administered before and after barbecue role and Gufoni maneuvers to fulfill the aim.  

Results: VAP scale results revealed significant difference between pre and post treatment score in both groups, suggestive of positive effect on quality of life in patients with HSCBPPV. Improvements in VAP score between both groups were compared and significant difference was observed. Positional test post treatment revealed that 83.33% and 70% patients improved in barbecue role and Gufoni respectively.

Conclusions: Barbecue role found to be better than Gufoni in treatment of unilateral HSCBPPV.
Ampliación del horizonte en la difusión de Cuadernos Latinoamericanos de Administración
Authors: González Bríñez Mario Hernán
Published: June 2020

La editorial se desarrolla en dos ejes, por una parte expone las ventajas de los indexadores a los cuales la revista ha ingresado, por otra parte, hace alusión brevemente a los artículos del número.
Associação entre percepção de saúde bucal e procura pelo serviço odontológico por gestantes
Authors: Saliba Tania Adas , Garbin Clea Adas Saliba , Custodio Lia Borges de Mattos , Castelli Lais , Saliba Nemre Adas , Moimaz Suzely Adas Saliba
Published: June 2020

Objetivo: Objetivou-se analisar a procura por atendimento odontológico e o perfil de gestantes.Materiais e Métodos: Trata-se de um estudo transversal, retrospectivo, de análise documental realizado em uma clínica de atendimento odontológico para gestantes. Os dados de saúde bucal foram coletados em 954 prontuários das gestantes atendidas entre 1999 e 2014. As variáveis estudadas foram: procura por atendimento odontológico, condições sociodemográficas e percepção sobre saúde bucal. Os dados foram analisados no software Epi Info e testes estatísticos foram realizados em nível de significância de 5%.Resultados: A média de idade das gestantes foi de 26 anos, 55,56% (n=530) brancas, 74,84% (n=714) residiam com o companheiro, 44,76% (n=427) trabalhavam, 44,23% (n=422) eram primigestas. Em relação a procura pelo serviço odontológico, a maioria (n=493) relatou sangramento gengival; 57,53% (n=210) não sentiam a boca saudável; 68,31% (n=248) não estavam satisfeitas com a aparência dos dentes. A procura por atendimento odontológico foi mais frequente entre gestantes que não sentiam sua boca saudável (p=0,01). Observou-se que 74,63% (n=712) das gestantes notaram alguma alteração bucal durante a gestação, mas a maioria (53,87%) não procurou atendimento odontológico.Conclusão: Concluiu-se que houve pouca procura por atendimento odontológico pelas gestantes, mesmo com necessidades reais de tratamento ou alterações bucais.
Discrimination of Malignant and Benign Breast Lesions Using Quantitative Multiparametric MRI: A Preliminary Study
Authors: Li Kurt , Machireddy Archana , Tudorica Alina , Moloney Brendan , Oh Karen Y. , Jafarian Neda , Partridge Savannah C. , Li Xin , Huang Wei
Published: June 2020

We aimed to compare diagnostic performance in discriminating malignant and benign breast lesions between two intravoxel incoherent motion (IVIM) analysis methods for diffusion-weighted magnetic resonance imaging (DW-MRI) data and between DW- and dynamic contrast-enhanced (DCE)-MRI, and to determine if combining DW- and DCE-MRI further improves diagnostic accuracy. DW-MRI with 12 b-values and DCE-MRI were performed on 26 patients with 28 suspicious breast lesions before biopsies. The traditional biexponential fitting and a 3-b-value method were used for independent IVIM analysis of the DW-MRI data. Simulations were performed to evaluate errors in IVIM parameter estimations by the two methods across a range of signal-to-noise ratio (SNR). Pharmacokinetic modeling of DCE-MRI data was performed. Conventional radiological MRI reading yielded 86% sensitivity and 21% specificity in breast cancer diagnosis. At the same sensitivity, specificity of individual DCE- and DW-MRI markers improved to 36%–57% and that of combined DCE- or combined DW-MRI markers to 57%–71%, with DCE-MRI markers showing better diagnostic performance. The combination of DCE- and DW-MRI markers further improved specificity to 86%–93% and the improvements in diagnostic accuracy were statistically significant (P < .05) when compared with standard clinical MRI reading and most individual markers. At low breast DW-MRI SNR values (<50), like those typically seen in clinical studies, the 3-b-value approach for IVIM analysis generates markers with smaller errors and with comparable or better diagnostic performances compared with biexponential fitting. This suggests that the 3-b-value method could be an optimal IVIM-MRI method to be combined with DCE-MRI for improved diagnostic accuracy.