bluuebunny/crossref_metadata_2025 huggingface dataset:
Paleolithic occupation of arid Central Asia in the Middle Pleistocene
Authors: Finestone Emma M. , Breeze Paul S. , Breitenbach Sebastian F. M. , Drake Nick , Bergmann Laura , Maksudov Farhod , Muhammadiyev Akmal , Scott Pete , Cai Yanjun , Khatsenovich Arina M. , Rybin Evgeny P. , Nehrke Gernot , Boivin Nicole , Petraglia Michael
Published: October 2022

Central Asia is positioned at a crossroads linking several zones important to hominin dispersal during the Middle Pleistocene. However, the scarcity of stratified and dated archaeological material and paleoclimate records makes it difficult to understand dispersal and occupation dynamics during this time period, especially in arid zones. Here we compile and analyze paleoclimatic and archaeological data from Pleistocene Central Asia, including examination of a new layer-counted speleothem-based multiproxy record of hydrological changes in southern Uzbekistan at the end of MIS 11. Our findings indicate that Lower Palaeolithic sites in the steppe, semi-arid, and desert zones of Central Asia may have served as key areas for the dispersal of hominins into Eurasia during the Middle Pleistocene. In agreement with previous studies, we find that bifaces occur across these zones at higher latitudes and in lower altitudes relative to the other Paleolithic assemblages. We argue that arid Central Asia would have been intermittently habitable during the Middle Pleistocene when long warm interglacial phases coincided with periods when the Caspian Sea was experiencing consistently high water levels, resulting in greater moisture availability and more temperate conditions in otherwise arid regions. During periodic intervals in the Middle Pleistocene, the local environment of arid Central Asia was likely a favorable habitat for paleolithic hominins and was frequented by Lower Paleolithic toolmakers producing bifaces.
Understanding super engaged users in the 10,000 Steps online physical activity program: A qualitative study
Authors: Vandelanotte Corneel , Hooker Cindy , Van Itallie Anetta , Urooj Anum , Duncan Mitch J.
Published: October 2022

Objective

Sustained engagement with Internet-based behavioural interventions is crucial to achieve successful behaviour change outcomes. As this has been problematic in many interventions, a lot of research has focused on participants with little or no engagement. However, few studies have attempted to understand users with continuous long-term engagement, the so called ‘super engaged users’, and why they keep on using programs when everybody else has long stopped. Therefore, the aim of this research was to qualitatively examine characteristics, usage profile and motivations of super engaged users in the 10,000 Steps program.

Methods

Twenty 10,000 Steps users (10 with more than 1 year of engagement, and 10 with more than 10 years of engagement) participated in semi-structured interviews, that were transcribed and thematically analysed.

Results

Participants were aged 60 years on average, with more than half being overweight/obese and/or suffering from chronic disease despite logging high step counts (219 million steps per participant on average) on the 10,000 Steps platform. Participants indicated that the reasons for sustained use were that engaging the program had become a habit, that the program kept them motivated, and that it was easy to use. Few participants had suggestions for improvement or expressed there were program elements they did not like. Uptake of program innovations (e.g., app-version, use of advanced activity tracker instead of pedometer) was modest among the super engaged users.

Conclusion

The findings from this study emphasise the need for digital health programs to incorporate features that will support the development of habits as soon as participants start to engage with the program. While a program’s usability, user-friendliness and acceptability are important to engage and retain new users, habit formation may be more important for sustained long-term engagement with the behaviour and the program.
A model of COVID-19 pandemic with vaccines and mutant viruses
Authors: Kim Young Rock , Choi Yong-Jae , Min Youngho
Published: October 2022

This paper proposes a compartment model (SVEIHRM model) based on a system of ordinary differential equations to simulate the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Emergence of mutant viruses gave rise to multiple peaks in the number of confirmed cases. Vaccine developers and WHO suggest individuals to receive multiple vaccinations (the primary and the secondary vaccinations and booster shots) to mitigate transmission of COVID-19. Taking this into account, we include compartments for multiple vaccinations and mutant viruses of COVID-19 in the model. In particular, our model considers breakthrough infection according to the antibody formation rate following multiple vaccinations. We obtain the effective reproduction numbers of the original virus, the Delta, and the Omicron variants by fitting this model to data in Korea. Additionally, we provide various simulations adjusting the daily vaccination rate and the timing of vaccination to investigate the effects of these two vaccine-related measures on the number of infected individuals. We also show that starting vaccinations early is the key to reduce the number of infected individuals. Delaying the start date requires increasing substantially the rate of vaccination to achieve similar target results. In the sensitivity analysis on the vaccination rate of Korean data, it is shown that a 10% increase (decrease) in vaccination rates can reduce (increase) the number of confirmed cases by 35.22% (82.82%), respectively.
Modeling of COVID-19 vaccination rate using odd Lomax inverted Nadarajah-Haghighi distribution
Authors: Almongy Hisham M. , Almetwally Ehab M. , Haj Ahmad Hanan , H. Al-nefaie Abdullah
Published: October 2022

Since the spread of COVID-19 pandemic in early 2020, modeling the related factors became mandatory, requiring new families of statistical distributions to be formulated. In the present paper we are interested in modeling the vaccination rate in some African countries. The recorded data in these countries show less vaccination rate, which will affect the spread of new active cases and will increase the mortality rate. A new extension of the inverted Nadarajah-Haghighi distribution is considered, which has four parameters and is obtained by combining the inverted Nadarajah-Haghighi distribution and the odd Lomax-Gfamily. The proposed distribution is called the odd Lomax inverted Nadarajah-Haghighi (OLINH) distribution. This distribution owns many virtuous characteristics and attractive statistical properties, such as, the simple linear representation of density function, the flexibility of the hazard rate curve and the odd ratio of failure, in addition to other properties related to quantile, therth-moment, moment generating function, Rényi entropy, and the function of ordered statistics. In this paper we address the problem of parameter estimation from frequentest and Bayesian approach, accordingly a comparison between the performance of the two estimation methods is implemented using simulation analysis and some numerical techniques. Finally different goodness of fit measures are used for modeling the COVID-19 vaccination rate, which proves the suitability of the OLINH distribution over other competitive distributions.
Comparison of three short-course rifamycin-based regimens for the prevention of tuberculosis in patients with end-stage kidney disease: Study protocol for a randomised clinical trial (RIFAKiD-TB trial)
Authors: Santin Miguel , Perez-Recio Sandra , Grijota Maria D. , Anibarro Luis , Barcala Jose M. , De Souza-Galvao Maria L. , Gijon Paloma , Luque Rafael , Sanchez Francesca ,   on behalf of the RIFAKiD team trial
Published: October 2022

Background and purpose

Screening for and treatment of latent tuberculosis (TB) in patients with end-stage kidney disease (ESKD) are recommended. However, there is limited evidence on safety and treatment completion in this population. The objective of the study is to evaluate three short-course rifamycin-based regimens for the treatment of latent TB in ESKD patients.

Methods

Study design and setting. This is a prospective, open label, randomized clinical trial, that will be conducted at seven teaching hospitals in Spain.

Study population, randomization, and interventions. Consecutive adult patients with ESKD requiring treatment for a latent TB infection will be randomly allocated (1:1:1) to receive one of the three treatment regimens of the study: three months of daily isoniazid plus rifampicin (3HR); three months of once-weekly isoniazid plus rifapentine (3HP); or four months of daily rifampicin (4R). Participants will be followed regularly through pre-established visits and a blood test schedule from enrolment to a month after finishing the assigned treatment.

Outcomes. The primary outcome will be treatment completion, while the secondary outcomes will be discontinuation of the assigned treatment due to adverse events, related or unrelated to the study treatment; definitive discontinuation of the assigned treatment because of adverse events related to the treatment of the study, and death.

Sample size. Two hundred and twenty-five subjects (75 per arm) will be enrolled, which will enable the demonstration, if it exists, of an increase of 0.16 in treatment completion rates either in the 3HP or 4R arm with respect to the 3HR arm.

Discussion

Results of this clinical trial will contribute to evidence-based recommendations on the management of latent TB infection in ESKD patients.

Trial registration

ClinicalTrials.gov identifier:NCT05021731.
Revealing key regulators of neutrophil function during inflammation by re-analysing single-cell RNA-seq
Authors: Ai Zhichao
Published: October 2022

Excessive neutrophil infiltration and dysfunction contribute to the progression and severity of hyper-inflammatory syndrome, such as in severe COVID19. In the current study, we re-analysed published scRNA-seq datasets of mouse and human neutrophils to classify and compare the transcriptional regulatory networks underlying neutrophil differentiation and inflammatory responses. Distinct sets of TF modules regulate neutrophil maturation, function, and inflammatory responses under the steady state and inflammatory conditions. In COVID19 patients, neutrophil activation was associated with the selective activation of inflammation-specific TF modules. SARS-CoV-2 RNA-positive neutrophils showed a higher expression of type I interferon response TF IRF7. Furthermore, IRF7 expression was abundant in neutrophils from severe patients in progression stage. Neutrophil-mediated inflammatory responses positively correlate with the expressional level of IRF7. Based on these results, we suggest that differential activation of activation-related TFs, such as IRF7 mediate neutrophil inflammatory responses during inflammation.
Identification of immune-related mechanisms of cetuximab induced skin toxicity in colorectal cancer patients
Authors: Park Jin Hyun , Kim Mi Young , Choi In Sil , Kim Ji-Won , Kim Jin Won , Lee Keun-Wook , Kim Jin-Soo
Published: October 2022

Skin rash is a well-known predictive marker of the response to cetuximab (Cmab) in metastatic colorectal cancer (mCRC). However, the mechanism of skin rash development is not well understood. Following exposure to EGFR-targeted therapies, changes in IL-8 levels have been reported. The aim of this study was to evaluate the association between skin rash and inflammatory cytokine levels, including IL-8. Between 2014 and 2017, we prospectively enrolled 38 mCRC patients who underwent chemotherapy with either Cmab or bevacizumab (Bmab) at two hospitals. We performed multiplex cytokine ELISA with 20 inflammatory cytokines including E-selectin, GM-CSF, IFN-alpha, IFN-γ, IL-1 alpha, IL-1 beta, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, IL-17A, IP-10, MCP-1, MIP-1 alpha, MIP-1 beta, P-selectin, sICAM-1, and TNF-alpha at baseline before cycle 1, 24 h after cycle 1, before cycle 2 (= 14 d), and before cycle 3 (= 28 d). Cytokine levels were compared using ANOVA after log-transformation. IL-8 genotypes in 30 patients treated with Cmab were determined using the polymerase chain reaction restriction fragment length polymorphism technique. Depending on the RAS mutational status, 30 and eight patients were treated with Cmab and Bmab-based chemotherapy, respectively. Skin rash developed in 23 (76.6%) of the 30 patients treated with Cmab plus FOLFIRI, after cycle 1. Only the mean log-transformed serum IL-8 level in patients with skin toxicity was statistically lower (2.83 ± 0.15) than in patients who did not experience skin toxicity (3.65 ± 0.27) and received Bmab (3.10 ± 0.26) (ANOVA test, p value = 0.0341). In addition, IL-8 polymorphism did not affect IL-8 levels, skin toxicity, or tumor response in Cmab treated patients. This study suggests that the inflammatory cytokine levels might be affected by Cmab exposure and are associated with the development of skin rash in mCRC patients. Further studies are warranted to evaluate this interaction in Cmab treated patients.
Unique estimation in EEG analysis by the ordering ICA
Authors: Matsuda Yoshitatsu , Yamaguchi Kazunori
Published: October 2022

Independent Component Analysis (ICA) is a method for solving blind source separation problems. Because ICA only needs weak assumptions to estimate the unknown sources from only the observed signals, it is suitable for Electroencephalography (EEG) analysis. A serious disadvantage of the traditional ICA algorithms is that their results often fluctuate and do not converge to the unique and globally optimal solution at each run. It is because there are many local optima and permutation ambiguities. We have recently proposed a new ICA algorithm named the ordering ICA, a simple extension of Fast ICA. The ordering ICA is theoretically guaranteed to extract the independent components in the unique order and avoids the local optima in practice. This paper investigated the usefulness of the ordering ICA in EEG analysis. Experiments showed that the ordering ICA could give unique solutions for the signals with large non-Gaussianity, and the ease of parallelization could reduce computation time.
Smart Living Technologies in the Context of Improving the Quality of Life For Older People: The Case of the Humanoid Rudy Robot
Authors: Halicka Katarzyna , Surel Dariusz
Published: October 2022

Smart living is an essential dimension of an ageing society because one of its measures includes living conditions (health, safety, housing). Many technological solutions are designed to satisfy the needs of older people living in cities. Humanoid robots are one of the technologies that can significantly improve the quality of life in older adults. The Rudy Robot is an example of a robot adapted to the needs of older people. The conducted research aimed to gain knowledge about the potential future use of the humanoid Rudy Robot by older adults in the context of smart living. The study mainly aimed to identify the robot’s most important functionalities that could improve older adults’ quality of life based on a literature review. In addition, the Rudy Robot was rated according to the most important criteria for evaluating the robot. The paper also examined whether age, sex, education and place of residence affect the assessment of the Rudy Robot technology. It should be noted that this technology is not available in Poland but has become known due to television, the Internet, etc. Respondents received a description of this technology, examples of use, and links to literature and films together with the questionnaire; thus, they knew what the Rudy Robot was and its characteristics, possibilities and potential.
Meningeal osteosarcoma in a dog’s brain
Authors: Moreira Pamela Rodrigues Reina , Rosolem Mayara Caroline , Maria G. Laranjeira  , Rafael R.M.E. da Costa  , Bethânia A. Gouveia  , Paulo H. L. Bertolo  , Gisele Fabrino Machado  , Rosemeri de Oliveira Vasconcelos
Published: October 2022

Osteosarcoma is the most common bone cancer in dogs. It has a high invasion capacity, commonly metastasize and it mainly arises in the medullary canal of long bones of the appendicular and axial skeleton, rarely affecting primarily extra-skeletal sites. Osteosarcoma of primary meningeal origin is extremely rare in human and veterinary medicine. A male, mixed breed dog was admitted at the Veterinary Hospital with a history of being overly excited, having decreased neurological reflexes and development of seizures. As the situation evolved, the animal was euthanized. The animal was referred to the Veterinary Pathology Service for necroscopic examination. The objective of this report was to describe a case of primary extra-skeletal osteosarcoma of the meninges in a dog, which presented clinical signs compatible with a disease originating in the central nervous system and which was diagnosed by histopathological and immunohistochemical analysis.
FOLIAR FERTILIZATION AT THE ESTABLISHMENT OF MARANDU, MAVUNO, MULATO AND YPYPORÃ GRASSES
Authors: Segatto Borges Gustavo , Alves Miler de Oliveira Dallety Haloma , Moraes de Oliveira Davi , Gonçalves Felisbino Douglas , De Oliveira Rocha Gabriel , Humberto Rezende de Carvalho Bruno , Rozalino Santos Manoel Eduardo
Published: October 2022

A adubação foliar com macro e micro minerais para o estabelecimento de gramíneas forrageiras pode ser uma alternativa menos onerosa ao produtor, contudo os possíveis benefícios dessa técnica de maneja ainda precisam ser melhor estudados. O objetivo deste trabalho foi avaliar as respostas fisiológicas, produtivas, estruturais de gramíneas do gênero, em função da aplicação ou não de adubo foliar durante o estabelecimento das plantas. Quatro experimentos foram conduzidos separadamente e concomitantemente, para avaliar, as seguintes gramíneas forrageiras: Urochloa brizantha cv. Marandu e os capins Mulato II, Mavuno e Ipyporã, híbridos de Urochloa. Os experimentos foram conduzidos de novembro de 2018 a março de 2019, em delineamento inteiramente casualizado, com quatro repetições. A área experimental de cada experimento consistiu de quatro parcelas com 12,25 m², onde metade da área das parcelas recebeu o adubo foliar (FH PASTAGEM FOLIAR, com 14% de N; 12% de P; 12% de K; 0,38 % de Mg; 10,2% de S; 0,24% de Cu; 0,18% de Mn e 0,63% de Zn) e a outra metade, não. O fertilizante foliar (2 kg ha-1) foi diluído em água e aplicado com pulverizador manual aos 42 dias após a emergência das plantas. Foram avaliadas as variáveis respostas: índice spad, índice de área foliar, interceptação de luz pelo dossel, produção de forragem e densidade de raiz. Em todos os experimentos, a aplicação do adubo foliar durante o estabelecimento dos capins Marandu, Mulato II, Mavuno e Ipyporã não influenciou os índices spad e de área foliar, a produção de forragem e a densidade de raiz.
PentaRay® Multielectrode Mapping Catheter for Atrial Tachyarrhythmia in Adults With Congenital Heart Disease
Authors: Dodeja Anudeep K. , Tan Yubo , Ackley Tamara , Russell Jennifer , Kertesz Naomi , Daniels Curt J. , Kamp Anna
Published: October 2022

Background

Ablation of atrial tachyarrhythmia in adults with congenital heart disease (ACHD) is challenging because of complex anatomy and high scar burden. We proposed that the addition of high-density mapping with the PentaRay® (Biosense Webster, Inc) mapping catheter (EAM+P) to 3-dimensional electroanatomic mapping (EAM) allows for rapid acquisition of high-resolution maps and shorter procedure times.

Methods

In this single-center, retrospective cohort study of patients with ACHD who underwent atrial arrhythmia ablation, patients were divided those who underwent ablation with EAM and those who underwent ablation with EAM+P.

Results

Fifteen ablations were performed in 13 patients using standard EAM, and 11 ablations were performed in 10 patients using EAM+P. There was no difference in mean age or complexity of congenital heart disease. The procedure duration was 1.5 times longer in the EAM than in the EAM+P group (P = .015). The dose area product was 12 times higher in the EAM than in the EAM+P group (P = .001). A higher number of venous access sites were used for EAM cases than for EAM+P cases (P = .008). Acute success rates of ablation and recurrence rates at 1 year were similar in the 2 groups. There were no procedure-related complications in either group.

Conclusion

This is the first study to evaluate the use of the PentaRay® high-density mapping catheter for ablation of atrial tachyarrhythmia in patients with ACHD. The use of the PentaRay® high-density mapping catheter results in shorter procedure time, decreased radiation exposure, and fewer venous access sites.
THE EFFECTIVENESS OF KAFFIR LIME PEEL EXTRACT (Citrus hystrix) ON PLASMA MALONDIALDEHYDE LEVEL IN DEMENTIA MICE
Authors: Ilham Muhammad , Mahati Endang , Muniroh Muflihatul , Nindita Yora
Published: October 2022

ABSTRACTBackground: Antioxidant is a substance that can catch and neutralize free radicals so that the process of oxidative stress can be stopped and cell damage can be avoided. Kaffir lime peel contains antioxidant compounds that have the potential to be the neuroprotective agent and can protect neurons from free radical-induced damage.Objective: To evaluate the effect of kaffir lime peel extract (Citrus hystrix) on the plasma malondialdehyde (MDA) level of mice induced by Scopolamine (SCM).Method: This research was a true experimental study with a post-test-only controlled group design. Thirty mice were randomly divided into 5 groups consisting of a healthy control (K+), Negative Control (K-), extract 5 mg/20gBW group (P1), 10 mg/20gBW group (P2), 20 mg/20gBW group (P3). SCM was injected intraperitoneally on days 1-7 and kaffir lime peel extract was given orally on days 2-7, the MDA levels testing of mice using TBARS method on day 8. Data analysis used One-Way ANOVA test and continued with Post Hoc LSD test.Results: The mean MDA levels of K+, K-, P1, P2, P3 were 4,212; 4,644; 3,481; 4,555; 4,733 nmol/mL, respectively. MDA levels of P1 were lower than K-, even though there were no statistically significant differences.Conclusion: There was no effect of administration kaffir lime peel extract (Citrus hystrix) on MDA levels in mice with scopolamine-induced dementia.Keywords: Citrus hystrix, malondialdehyde, dementia, mice
Pengaruh Harga Dan Experiential Marketing Terhadap Loyalitas Pelanggan Melalui Kepuasan Konsumen Sebagai Variabel Intervening Pada Konsumen General Repair PT Nasmoco Pemuda Semarang
Authors: Dilla Sri Farah , Ngatno Ngatno
Published: October 2022

Abstract: Total of customers General Repair Service of PT Nasmoco Pemuda Semarang has fluctuated due to customer commitment changes. This study aims to determine the effect of price and experiential marketing on customer loyalty through customer satisfaction as an intervening variable in the General Repair Service of PT Nasmoco Pemuda Semarang. This research is explanatory research with an accidental sampling method before the pandemic and purposive sampling after the pandemic. It used interviews and questionnaires as a data collection technique to 100 respondents, whoever uses General Repair service at PT Nasmoco Pemuda Semarang City. The data covered area on Central Semarang, North Semarang, East Semarang , South Semarang, Gajahmungkur, and Candisari. This sub-districts are the largest contributor to the General Repair Service of PT Nasmoco Pemuda Semarang customers. This research used the SPSS 21.0 application and Sobel analysis. The Sobel test results state that customer satisfaction is able to partially mediate between price and experiential marketing on customer loyalty. The correlation coefficient of price and experiential marketing variables to customer satisfaction has a strong relationship. Company should offering some discounts to be more engaging. Other than that, to not neglect the quality of the facilities that already served at PT Nasmoco Pemuda Semarang General Repair, for example, WiFi.Keywords: Price; Experiential Marketing; Customer Satisfaction; Customer Loyalty Abstrak: Jumlah pelanggan Layanan General Repair PT Nasmoco Pemuda mengalami fluktuatif yang disebabkan adanya perubahan komitmen pelanggan. Penelitian ini bertujuan untuk mengetahui pengaruh harga dan experiential marketing terhadap loyalitas pelanggan melalui kepuasan konsumen sebagai variabel intervening pada Layanan General Repair PT Nasmoco Pemuda Semarang. Tipe penelitian ini adalah explanatory research dengan metode accidental sampling sebelum pandemi dan purposive sampling setelah pandemi. Teknik pengumpulan data menggunakan wawancara dan kuesioner kepada 100 responden yang pernah melakukan service pada layanan General Repair PT Nasmoco Pemuda Kota Semarang yang berdomisili Kecamatan Semarang Tengah, Semarang Utara, Semarang Timur, Semarang Selatan, Gajahmungkur dan Candisari. Teknik analisis data menggunakan aplikasi SPSS 21.0 serta analisis sobel. Hasil uji Sobel menyatakan bahwa kepuasan konsumen mampu memediasi parsial antara harga dan experiential marketing terhadap loyalitas pelanggan. Koefisiensi korelasi harga dan experiential marketing terhadap kepuasan konsumen memiliki hubungan yang kuat. Perusahaan hendaknya meningkatkan potongan harga yang lebih menarik dan lebih memperhatikan fasilitas yang ada pada layanan General Repair PT Nasmoco Pemuda Semarang seperti WiFi.Kata Kunci: Harga; Experiential Marketing, Kepuasan Konsumen; Loyalitas Konsumen
Pengaruh E-Wom Terhadap Repurchase Intention Melalui E-Trust Sebagai Mediasi Pada Konsumen Tiket Kereta Di Kai Access (Studi Pelanggan Kereta Argo Sindoro Jurusan Semarang-Jakarta Pada Kai Access Kota Semarang)
Authors: Putri Erika Aulia , Pradhanawati Ari
Published: October 2022

Abstract: One type of transportation that fits these criteria is the Indonesian Railroad. PT KAI itself has various types of train levels, such as economy class, business class, and executive class. The purpose of this study was to determine the effect of e-WOM on repurchase intention through e-trust as a mediation for train ticket consumers through KAI Access. The data collection technique used a questionnaire that was distributed to 100 KAI Access consumer respondents in Semarang. The analysis technique of this research is using the SPSS version 16.0 program. The results show that e-WOM has a positive and significant effect on repurchase intention, e-trust has a positive and significant effect on repurchase intention, e-WOM has a positive and significant effect on e-trust, e-WOM has a positive and significant effect on repurchase intention through e-trust mediation. Based on the research results, it is suggested that KAI Access can improve the features of the application system to make it easier for consumers to get information, expand e-money partners so that consumers make payments easier, and improve the quality of the security system on KAI Access to minimize consumer concerns in the event of a server disturbance. Keywords: e-WOM; e-trust; Repurchase Intention Abstrak: Salah satu jenis transportasi yang cocok untuk kriteria tersebut adalah Kereta Api Indonesia. PT.KAI sendiri memiliki berbagai jenis tingkatan kereta, seperti kelas ekonomi, kelas bisnis, dan kelas eksekutif. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh e-WOM terhadap repurchase intention melalui e-trust sebagai mediasi pada konsumen tiket kereta api melalui KAI Access. Teknik pengumpulan data menggunakan kuesioner yang dibagikan kepada 100 responden konsumen KAI Access di Semarang. Teknik analisis penelitian ini menggunakan program SPSS versi 16.0.  Hasil penelitian menunjukkan bahwa e-WOM berpengaruh positif dan signifikan terhadap repurchase intention, , e-trust berpengaruh positif dan signifikan terhadap repurchase intention, e-WOM berpengaruh positif dan signifikan terhadap e-trust, e-WOM berpengaruh positif dan signifikan terhadap repurchase intention melalui mediasi e-trust. Berdasarkan hasil penelitian maka disarankan supaya KAI Access dapat meningkatkan fitur pada sistem aplikasi untuk memudahkan konsumen mendapatkan informasi, memperluas mitra e-money agar konsumen lebih mudah melakukan pembayaran, dan meningkatkan kualitas sistem keamanan pada KAI Access meminimalisir kekhawatiran konsumen jika terjadi gangguan server.Kata kunci: e-WOM; e-trust; Repurchase Intention
Village’s Digital Capital: Positioning and Implementation Concept
Authors: Rahmawati Emma , Faubiany Varenna , Aldha Mauliddina Siregar Nurul , Daniarta Sukarno Taufan
Published: October 2022

The progress of a region cannot be separated from the development of digitalization. Now, digitalization is very important in development, because it is a capital that interacts with five offline capitals as social capital, economic capital, personal capital, political capital, and cultural capital owned by the community so that it will improved welfare, income, health, and others. Digital village is an idea that is being proclaimed by local government in collaboration with rural government. Punggul village Badung Region and Beraban village Tabanan Region in Bali Province already programmed digital village in their village development. The purpose of this research is to describe how digitalization is applied in services to the community and village development and how to carry out digitalization as a capital carried out by the Punggul and Beraban Village Governments. This research uses qualitative research methods with case study. Data collecting methods uses interview, observation, and documentation. This research result show us about the position interaction between digital capital and five offline capitals in Punggul village and Beraban village the same is in “the third level of digital divide” which internet used driven by and for the increasing offline capital. While the relationship between digital capital and five offline capital, the Punggul village is the ideal type and Beraban village is the third level of ideal scenario. Digitalization in both of villages become a supportive capital in improving villagers welfare.
Analisis Tata Kelola Teknologi Informasi (IT Governance) Menggunakan COBIT 5 (Studi Kasus di UPT Puskom Universitas Diponegoro)
Authors: Rizki Kana , Bahtiar Nurdin
Published: October 2022

Salah satu bagian penting dari tata kelola Teknologi Informasi (TI) adalah dalam hal perancangan dan penerapan struktur dan kontrol untuk mengukur tingkat kematangan kinerja TI yang sudah diterapkan dan memberikan nilai dan kontribusi kepada para pemangku kepentingan baik dari internal maupun eksternal. Unit Pelaksana Teknis Pusat Komputer (UPT Puskom) Undip merupakan unit pelaksana teknis di bidang pengolahan data yang bertanggung jawab kepada Rektor Undip. UPT Puskom Undip mempunyai tugas mengumpulkan, mengolah, menyajikan, serta memberikan layanan data dan informasi untuk pendidikan, penelitian, dan pengabdian masyarakat. Mengingat pentingnya tugas UPT Puskom Undip tersebut maka perlu dilakukan suatu pengendalian sistem tata kelola TI UPT Puskom Undip. Salah satu teknik yang dapat dilakukan untuk pengendalian tersebut adalah dengan cara mengukur tingkat kematangan sistem tata kelola TI UPT Puskom Undip. Oleh karena itu maka dilakukan analisis pada tata kelola TI dengan menggunakan kerangka kerja COBIT 5. Analisis dilakukan dengan teknik observasi, wawancara, penelaahan dokumen, dan konfirmasi untuk mendukung analisis terhadap UPT Puskom Undip. Aplikasi analisis tata kelola teknologi informasi dibangun dengan menggunakan bahasa Hypertext Preprocessor (PHP), framework Code Igniter (CI), dan sistem manajemen database MySQL. Aplikasi tersebut dibangun untuk mengolah data UPT Puskom Undip sehingga dapat menghasilkan tingkat kematangan sistem tata kelola teknologi informasi. Hasil analisis menunjukkan bahwa tingkat kematangan sistem tata kelola teknologi informasi UPT Puskom Undip adalah 2,88 yaitu di tingkat Established Process. Pada tingkat Established Process proses telah dikelola dan dikomunikasikan.
Die „wilden Siebziger“ und ihre „gegnerischen Soziologien“.
Authors: Moebius Stephan , Römer Oliver
Published: October 2022

Gegenstand des Beitrages ist die historische Konstellation der westdeutschen Soziologie der 1970er Jahre. Während die Anfänge der bundesrepublikanischen Soziologie ein inzwischen gut untersuchtes Feld sind, bleiben die fachlichen Entwicklungen und Besonderheiten dieser Dekade bisher stark unterbeleuchtet. In den 1960er Jahren als gesellschaftliche Orientierungs- und Reformdisziplin entdeckt, wurde die Soziologie in den Siebzigern zum Ort eines vielschichtigen Kulturkampfes, der unterschiedliche Hoffnungen, Befürchtungen und Parteilichkeiten aufeinander bezog. Mit der gesteigerten gesellschaftlichen Wahrnehmung und Einbeziehung soziologischen Wissens und Denkens in den gesellschaftlichen Diskurs gingen unterschiedlichste Formen der Polarisierung einher. Inwiefern bietet die soziologische Konstellation der siebziger Jahre einen alternativen Modellfall für die Konstitutionalisierung der Sozialwissenschaften, der weder von wissenschaftslogisch begründeten Konzepten einer Einheitswissenschaft noch von Parteinahmen für eine soziologische Theorien- und Methodenpluralität gedeckt ist?
Hypoxia promotes osteogenesis by facilitating acetyl‐CoA‐mediated mitochondrial–nuclear communication
Authors: Pouikli Andromachi , Maleszewska Monika , Parekh Swati , Yang Ming , Nikopoulou Chrysa , Bonfiglio Juan Jose , Mylonas Constantine , Sandoval Tonantzi , Schumacher Anna‐Lena , Hinze Yvonne , Matic Ivan , Frezza Christian , Tessarz Peter
Published: October 2022

Bone‐derived mesenchymal stem cells (MSCs) reside in a hypoxic niche that maintains their differentiation potential. While hypoxia (low oxygen concentration) was reported to critically support stem cell function and osteogenesis, the molecular events triggering changes in stem cell fate decisions in response to normoxia (high oxygen concentration) remain elusive. Here, we study the impact of normoxia on mitochondrial–nuclear communication during stem cell differentiation. We show that normoxia‐cultured murine MSCs undergo profound transcriptional alterations which cause irreversible osteogenesis defects. Mechanistically, high oxygen promotes chromatin compaction and histone hypo‐acetylation, particularly on promoters and enhancers of osteogenic genes. Although normoxia induces metabolic rewiring resulting in elevated acetyl‐CoA levels, histone hypo‐acetylation occurs due to the trapping of acetyl‐CoA inside mitochondria owing to decreased citrate carrier (CiC) activity. Restoring the cytosolic acetyl‐CoA pool remodels the chromatin landscape and rescues the osteogenic defects. Collectively, our results demonstrate that the metabolism–chromatin–osteogenesis axis is perturbed upon exposure to high oxygen levels and identifies CiC as a novel, oxygen‐sensitive regulator of the MSC function.
Thermo-hydrolytic recycling of urea-formaldehyde resin-bonded laminated particleboards
Authors: Fu Qilan , Zhuang Biaorong , Wang Xiang-Ming , Cloutier Alain , Roussière Fabrice , Bouffard Jean-François
Published: October 2022

The large global production of particleboards creates an equal quantity of particleboard waste after completion of their service life. Given increasing demand for green products and government environmental policies, it is urgent to develop technologies to recycle these used composite panels into valuable raw materials. This study was conducted to recover particles from waste laminated particleboards using various thermo-hydrolytic treatments. The recovered particles were used as raw materials with different substitutions of fresh particles to manufacture particleboard panels. The performance of the resulting particleboards was evaluated in terms of their mechanical properties and formaldehyde emissions. The nitrogen content of the control and resulting particles were measured to determine the resin removal in recycled particles. The results suggested that different thermo-hydrolytic treatments did not have significant influence on particles size distribution. Approximately 65% of urea-formaldehyde resin was removed from the particleboards treated at 140 °C/20 min. Particles recycled at 140 °C/20 min were comparable to fresh particles in terms of mechanical properties and formaldehyde emissions, and 100% of the recycled particles were used in the manufacture of particleboard without an adverse impact on the board performance.
UKRAINE’S POST-WAR ECONOMY: INTERNATIONAL AID AND GROWTH POLICY
Authors:   State Institution “Institute for Economics and Forecasting, NAS of Ukraine”, Oleh Pustovoit
Published: October 2022

The full-scale war unleashed in 2022 by the Russian Federation against Ukraine is accompanied by massive destruction of infrastructure and industrial facilities. Their rapid recovery is impossible without international assistance. However, it is known from history that the use of such aid did not always lead to accelerated post-war recovery of countries whose markets and economies are developing. Knowledge of such facts urged Western scientists to search for a mechanism of aid's impact on economic growth. Researches that began in the 1960s did not shed light on this mechanism. However, they did show that aid speeded up economic growth and recovery in countries that conducted better fiscal, monetary, and trade policies and succeeded in establishing the rule of law. In the article, a slightly different scientific approach is substantiated. It assumes that when the country implements not only a better fiscal, monetary, foreign trade, institutional, but also structural economic policy, the impact of international aid on postwar economic growth can significantly increase. The proposed approach gives grounds for the statement that the limited amount of aid in Ukraine should not be dissipated on the reconstruction of all industrial facilities destroyed and damaged by the war, but it is advisable to concentrate it on the restoration of enterprises that are able to start production and sale of high technological complexity products on international markets within a short period. The advantages of such use of the aid are shown by calculation. It shows that directing international aid at expanding exports of high technological complexity items would create in Ukraine favorable conditions for increasing the post-war annual growth rates of commodity production to 10% and reduce the period of recovery of this indicator to the 2021 level from 12 to 6 years. At the same time, arguments are given that the proposed use of aid is only a means of shortening the terms of the economy's exit from the crisis and its transition to a state of accelerated growth. It will be possible to turn this state into a long-term economic trend only if an effective mechanism is introduced for encouraging the companies’ innovative activities and attracting foreign investments in industries producing items of high technological complexity. Modeling possible scenarios of the post-war recovery of Ukraine's economy somewhat expands the scientific understanding of the mechanism of aid's effect on a country’s economic growth. In particular, it is supplemented by the idea that in the post-war period, international aid plays the role of a driver of high rates of a country’s economic growth to the extent that it contributes to economic restructuring of the production from military to civil mode transforming it from technologically simple to more technologically complex.
Assassinatos em massa
Authors: Welter Lisiane dos Santos , Vasconcellos Silvio Jose Lemos , Barbosa Thamires Pereira , Lucchese Vanessa Cirolini , Steffler Hellin Thais
Published: October 2022

Este estudo tem como objetivo analisar as ocorrências de assassinatos em massa no Brasil e as características desses crimes na literatura internacional. Foi realizada uma pesquisa on-line com base na análise temática sobre os assassinatos em massa ocorridos no Brasil, que datam de 1999 a 2019, com um total de seis casos. Todos eles foram perpetrados por homens, com idades entre 14 e 50 anos, com características narcísicas, isolamento e alienação social segundo informações obtidas no noticiário. Os textos consultados também sugerem que os transtornos mentais podem predispor ao crime, assim como o bullying. Verificou-se também que nenhuma das notícias mencionava programas de prevenção, apenas enfatizando o crime e a comoção provocada. Sugere-se novas pesquisas sobre o assunto, notoriamente escassas no Brasil, para compreender esse fenômeno à luz da cultura do país e poder atuar preventivamente para evitar desfechos semelhantes no território brasileiro.
Issues of narrowness and staticity in ISLA
Authors: Han ZhaoHong
Published: October 2022

Interest in instructed second-language acquisition (ISLA) (i.e., the learning of an additional language in a formal setting), has been with us since the inception of the field of second-language acquisition (e.g., Corder, 1967). How the learning outcome can be effectively and efficiently improved through external intervention has been a perennial yet fascinating question for scholars and practitioners alike. Collectively, extant studies are illuminating, but many are palpably one-off attempts, atomistic and reductionist in their conceptualisation, implementation and interpretation. As such, they are prone to weak internal and external validity. In this article, I call attention to two issues – narrowness and staticity – in this body of work, advancing a case for the necessity to adopt a systemic and dynamic approach to investigating instructed learning. I close by proffering thoughts on how to enact such an approach in experimental and natural settings.
The conflict between the State of Chile and the Mapuche people in the national and regional Chilean press (2014-2016)
Authors: Hudson Eileen , Dussaillant Francisca
Published: October 2022

This is a comparative study that analyzes the issues and the sources usage related to the conflict between the State of Chile and the Mapuche people in El Mercurio, national press, and El Austral de La Araucanía, regional press. Front pages published during the first two years of Michelle Bachelet’s presidency (2014-2016) conform the corpus of this research. A mixed methodology was applied and a multivariable content analysis was developed (N=603). Although both media belong to the same conglomerate, proximity with Mapuche’s traditional land had a decisive influence in news content. El Austral gave priority to the political discussion meanwhile El Mercurio emphasized violent events and their consequences in regional economic development. Mapuche’s were considered main actors in the news selection of the national newspaper but they were not quoted as sources. El Austral, instead, included Mapuches with political –national and regional– sources.
La hermenéutica del Concilio Vaticano II
Authors: Villar José R.
Published: October 2022

La centralidad del corpus documental del Concilio Vaticano II hace igualmente central su interpretación. La interpretación de los concilios precedentes, desde la exacta contraposición con el error que querían rechazar, resulta inaplicable en el caso del Vaticano II. Su peculiar fisonomía pide una hermenéutica y unos criterios formales propios: la atención a la historia del texto; su consideración como textos de un único sujeto magisterial; la necesidad de articular la continuidad y la novedad, en el contexto del desarrollo dogmático tradicional.
Zawezwanie do próby ugodowej a przerwanie biegu przedawnienia – rozważania na kanwie wyroku Sądu Najwyższego z dnia 17 czerwca 2021 r., sygn. II CSKP 104/21
Authors:   Uniwersytet Jagielloński, Kraków, Polska, Krupowicz Bartłomiej
Published: October 2022

The influence of a summon to a conciliation hearing on interruption of limitation periods evokes many controversies in polish judicature and legal literature. The disputes are focused on the problem: does a summon to a conciliation hearing belong, in general, to acts, which are included in art. 123 § 1 pkt 1 of the Civil Code – and if so – has the real intention of a creditor, who summons to a conciliation hearing, any meaning. In commented judgment Supreme Court stated, that the intention of a creditor is meaningless – interruption of limitation periods of a claim is so called ex lege effect of the summon. Standing up against that conclusion, the author presented counter-arguments, which include the reinterpretation of art. 123 of the Civil Code. The article brings up the need to consider linguistic, systemic and functional perspective during the process of evaluation of the institution of limitation. Possibility of application art. 5 of the Civil Code and art. 4 1 of the Civil Procedure Code was taken into account as well.
Z problematyki odmowy udzielenia aktu uwarunkowanego przyrzeczeniem administracyjnym
Authors:   Uniwersytet Ekonomiczny w Krakowie, Polska, Chlipała Monika
Published: October 2022

The subject of this article is the description of legal regulations concerning the refusal to issue an act conditional on a promise. Under the current legal framework, the prevailing solution is that during the period of validity of the promise, refusal to issue a license (permit) is permitted only if certain conditions are met. This is justified by the guarantee function of the administrative promise, which is expressed in the promise of the authority to issue a specific act in the future. The article discusses the reasons for refusing to issue a promised act, legal regulations related to the authority’s competence to make a negative decision and the refusal control by administrative courts. It was also proposed to treat the refusal to issue an act conditional on a promise as a quasi-administrative sanction.
Remote Monitoring of Air Quality in the City of Volgograd
Authors:   Volgograd State University, Venetsiansky Alexey , Ivantsova Elena ,   Volgograd State University, Shulikina Maria ,   Volgograd State University
Published: October 2022

In large cities, one of the significant problems is air pollution, which can harm both the health of the population and the environment as a whole. At the same time, a person cannot always independently determine the risk assessment and take the necessary measures. Therefore, the main source of knowledge for the population is informing about the environmental situation and about observations of the processes and phenomena that occur in the external environment. The quality of monitoring and forecasting of emergency situations has a decisive influence on the effectiveness of activities in the field of reducing the risks of their occurrence and scale. The Volgograd region is a region with a developed diversified industry. Among industrial facilities, such industries as metallurgical, chemical, fuel and construction are characterized by the highest emissions. In addition, food and light industry enterprises, industrial and domestic boiler houses are located in the region, which also contribute to the overall level of air pollution in the atmosphere. In this regard, the purpose of the study is to conduct satellite monitoring of air quality in the industrial center of the Volgograd region – the city of Volgograd. The article presents the results of remote monitoring from February to April 2022, where the criteria for air pollutants were calculated. According to the calculations obtained, an assessment of the pollution of the selected industrial center of the Volgograd region was obtained. To assess the level of air pollution, both international and Russian indicators were used and the following conclusion was reached. The system, which is adopted in Russia and the CIS countries, allows for a comprehensive assessment of air pollution. Thus, pollutants are normalized both by MPC and by the air pollution index.