bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictors of Long-COVID-19 and its Impact on Quality of Life: Longitudinal Analysis at 3, 6 and 9 Months after Discharge from a Portuguese Centre
Authors: Gaspar Pedro , Dias Mariana , Parreira Inês , Gonçalves Hélder Diogo , Parlato Federica , Maione Valeria , Atalaia Barbacena Henrique , Carreiro Carolina , Duarte Leila
Published: February 2023

Introduction: Long-COVID-19 impacts health-related quality of life (HR-QoL) but data is scarce. The aim of this study was to describe and prospectively assess the prevalence and risk factors for long-COVID-19 after hospital discharge, and to evaluate its impact on patient HR-QoL.Methods: Single-centre longitudinal study including all COVID-19 patients discharged between December 2020 and February 2021. Patients were contacted remotely at three, six and nine months. Data were collected as follows: 1) Long-COVID-19 symptoms were self-reported; 2) HRQoL were assessed using the 3-level EuroQoL-5D (EQ-5D-3L) questionnaire. Pregnant women, demented, bedridden, and non-Portuguese-speaking patients were excluded.Results: The three-, six- and nine-month assessments were completed by 152, 117 and 110 patients (median age: 61 years; male sex: 56.6%). Long-COVID-19 (≥ 1 symptom) was reported by 66.5%, 62.4% and 53.6% of patients and HR-QoL assessment showed impairment of at least some domain in 65.8%, 69.2% and 55.4% of patients at three, six and nine months, respectively. Fatigue was the most common long-COVID-19 symptom. Anxiety/depression domain was the most frequently affected in all three time-points, peaking at six months (39%), followed by pain/discomfort and mobility domains. Long-COVID-19 was associated with the impairment of all EQ-5D-3L domains except for self-care domain at each time-point. Neither intensive care unit admission nor disease severity were associated with long-COVID-19 nor with impairment of any EQ-5D-3L domain. After adjusting for sex, age, frailty status, and comorbid conditions, long-COVID-19 remained significantly associated with HR-QoL impairment at three (OR 4.27, 95% CI 1.92 – 9.52, p < 0.001), six (OR 3.46, 95% CI 1.40 – 8.57, p = 0.007) and nine months (OR 4.13, 95% CI 1.62 – 10.55, p = 0.003) after hospital discharge. In alongitudinal analysis, patients reporting long-COVID-19 at three months had an EQ-5D-3L index value decreased by 0.14 per visit (p < 0.001) compared to those without long-COVID-19 and both groups had a non-significant change in mean EQ-5D-3L index over the nine-month period (time-point assessment, Z = 0.91, p = 0.364).Conclusion: Clinical sequelae associated with long-COVID-19 can persist for at least nine months after hospital discharge in most patients and can impair long-term HR-QoL in more than half of patients regardless of disease severity, and clinicodemographic characteristics.
Comparative analysis of machine learning methods for detecting malicious files
Authors: Nafiiev Alan , Kholodulkin Hlib , Rodionov Andrii
Published: February 2023

Nowadays, one of the most critical cyber security problems is the fight against malicious software, precisely, the problem of detecting it. Every year, new modern computer viruses are created that are capable of mutation and changing while running. But unfortunately, the developers of antivirus software do not have time to quickly add all types of malicious programs to the signature databases. In this regard, it is sensible to use heuristic detection methods based on algorithms of machine learning. The purpose of this paper is to present several classification methods based on machine learning techniques for detecting zero-day attacks. In particular, the following algorithms were tested: random forest classifier, support vector classifier, greed search in svc, and k-nearest neighbors. The dataset was taken from the Kaggle website. It consists of 19611 executable files of the PE format, 14599 of which are malicious, and 5012 files are benign. This article presents recommended classification and detection methods with advanced analysis of important metrics that allow you to assess and compare machine learning algorithms’ effectiveness and performance for detecting malware.
Technique of testing cyber vulnerabilities and quality of Cyberphysical software systems
Authors: Danyk Yuriy , Vysochanska Victoriya
Published: February 2023

Cyber vulnerability testing and software quality cyberphysical systems (complexes) is an important task in ensuring its reliability and security. When working with several variations of products or their versions, testing all software for every variation is resource intensive and irrational. To implement effective technological and economical quality of testing and cyber vulnerabilities of cyberphysical systems software (complexes) in terms of its increasing complexity, both in time (when considering the version) and in space (when considering variation) and lack of access to program code should be developed as follows new methods. Those methods will allow to use the results of previous tests and focus on the most important, for their testing, not yet tested parts. This is possible using regression testing methods and the appropriate choice of test cases and their prioritization to identify and address software issues and cyber vulnerabilities. Of course, testing variations and versions without access to source code, is an extremely problematic and costly task. The article analyzes the stages of regression testing and proposes an improved method for selecting test cases for testing of cyber vulnerabilities of software of cyberphysical systems (complexes) without access to program code. During the study, an analysis of the achievements in this area was conducted, investigating leading experts works. This article also identifies and compares the effectiveness of prioritized and non-prioritized test cases using the average percent detection rate (APFD). As a result of the study, new metrics for measuring test coverage are presented.
Reference functions of cyber incidents displaying in the media space
Authors: Lande Dmytro , Novikov Oleksii , Stopochkina Iryna
Published: February 2023

The principles of cyber attacks detection that based on media content are described. Proposed methods are suitable for description of the general trends in the dynamics of information flows concerning cyber incidents. A generalized diagram of cyber attacks stages displaying in the media space is proposed. On the basis of the diagram the basic wavelet functions are selected, which can be considered as a reference for detecting cyber incidents. The proposed wavelets are low-order derivatives of Gaussian function (Wave, «Mexican Hat» and Morlaix wavelets). Retrospective analysis of already implemented information operations is a reliable way to verify them. The problem of forecasting is partly solved by probabilistic estimates in accordance with the type of reference functions.
On the Security of Qalqan Cipher Against Differential Cryptanalysis
Authors: Yakovliev Serhii , Stolovych Mykhailo
Published: February 2023

In 2021, the first version of block cipher Qalqan was presented. It is positioned as a candidate to the future national encryption standard of the Republic of Kazakhstan. This cipher features the usage of addition by different modules for mixing the round keys and for linear layer. In this work, we consider some cryptographic properties of Qalqan, related with the security against differential and linear cryptanalysis. We present variations of cipher’s S-box with better cryptographic properties. We prove that branch number of Qalqan’s linear layer is equal to 3, and the layer itself has a significant amount of fixed points. Also, we build a set of multi-round differential characteristics with high probabilities for the modified version of the Qalqan cipher, which uses only addition modulo 256. With these results, we can argue that the declared security of Qalqan against differential and linear cryptanalysis should be reconsidered.
Model of rules for malicious input parameters detection
Authors: Korzhenevskyi Oleksandr , Graivoronskyi Mykola
Published: February 2023

This article is devoted to detection of advanced techniques of malicious input parameter injections and web application firewall (WAF) bypass. The authors have proposed a hierarchical model for detection rules definition, which allows to edit different fragments separately. This model has been implemented with the usage of Backus-Naur form and ANTLR4 (generator of parsers and lexers). The solution has been tested using some popular web application scanners. The testing environment has been created with Python3. The results of research have been compared with the corresponding ones for the existing open source solution – libinjection. The main accent has been made to SQL injcetions and Cross-Site Scripting attacks.
An Inhomogeneous Steady-State Convection of a Vertical Vortex Fluid
Authors:   Ural Federal University, Berestova S. A. ,   Institute of Engineering Science of Ural Branch of the Russian Academy of Sciences, Prosviryakov E. Yu.
Published: February 2023

An exact solution of the Oberbeck – Boussinesq equations for the description of the steady-state Bénard – Rayleigh convection in an infinitely extensive horizontal layer is presented. This exact solution describes the large-scale motion of a vertical vortex flow outside the field of the Coriolis force. The large-scale fluid flow is considered in the approximation of a thin layer with nondeformable (flat) boundaries. This assumption allows us to describe the large-scale fluid motion as shear motion. Two velocity vector components, called horizontal components, are taken into account. Consequently, the third component of the velocity vector (the vertical velocity) is zero. The shear flow of the vertical vortex flow is described by linear forms from the horizontal coordinates for velocity, temperature and pressure fields. The topology of the steady flow of a viscous incompressible fluid is defined by coefficients of linear forms which have a dependence on the vertical (transverse) coordinate. The functions unknown in advance are exactly defined from the system of ordinary differential equations of order fifteen. The coefficients of the forms are polynomials. The spectral properties of the polynomials in the domain of definition of the solution are investigated. The analysis of distribution of the zeroes of hydrodynamical fields has allowed a definition of the stratification of the physical fields. The paper presents a detailed study of the existence of steady reverse flows in the convective fluid flow of Bénard – Rayleigh – Couette type.
Распространение вариантов вируса SARS-COV-2, вызывающих озабоченность (VOC) на основе количества их геномов, депонированных в базу данных GISAID за неделю с 18.02.2023 г. по 24.02.2023 г.
Authors: Дмитриева Людмила , Краснов Ярослав , Чумачкова Елена , Осина Наталья , Зимирова Анастасия , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Шербакова Светлана , Кутырев Владимир
Published: February 2023

В обзоре представлена информация по циркулирующим в настоящее время вариантам вируса SARS-COV-2 вызывающих озабоченность (VOC), геномные последовательности которых размещены в международной базе данных GISAID за неделю с 18 по 24 февраля 2023 г.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 18.02.2023 г. по 24.02.2023 г.
Authors: Зимирова Анастасия , Поспелов Михаил , Иванова Александра , Дмитриева Людмила , Чумачкова Елена , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир
Published: February 2023

В обзоре представлен анализ эпидемиологической ситуации в странах мира по

COVID-19 за неделю с 18.02.2023 г. по 24.02.2023 г.
Tipología del rey en los relatos míticos de la Grecia antigua
Authors: Asencio González Emilio
Published: February 2023

Los relatos míticos de la Grecia antigua dan numerosos ejemplos de las terribles fuerzas sobrenaturales que desencadenaba la divinidad ante los crímenes del soberano. El rey, como vástago de Zeus y elegido por él mismo, debía de rendirle cuentas, de modo que recibía la contestación positiva de la naturaleza cuando se comportaba rectamente, mientras que, si caía en la injusticia o en la arrogancia, la ira divina se lanzaba contra él y toda su comunidad. Tales relatos tenían un carácter aleccionador y trataban tanto de mantener el orden ancestral como de establecer modos de purificación y expiación.
Léxico botánico en el Cancionero de Baena
Authors: LÓPEZ QUERO Salvador , QUINTANA RAMOS Ángel
Published: February 2023

Muchos términos botánicos se documentan por primera vez en el Cancionero de Baena. Los de uso médico son los más numerosos. Algunos de estos términos se utilizan con un sentido figurado. Otros términos botánicos se relacionan con el color, el olor, el adorno, la forma o la materia. Hay también términos de significado meramente denotativo, incluso ingeniosas asociaciones y dobles sentidos, basados a veces en la forma, como nos puede mostrar un análisis pragmático de los enunciados.
Sobre la tendencia en el uso de las locuciones: un estudio contrastivo
Authors: MARTÍNEZ LÓPEZ Juan A.
Published: February 2023

El presente estudio tiene como fin llevar a cabo un estudio contrastivo a fin de constatar o desmentir la afirmación según la cual hay una tendencia a disminuir el uso el uso de las formas fijadas de la lengua. A este fin recogemos un corpus de locuciones preposicionales, en concreto de aquellas iniciadas mediante la preposición a: se trata de la fatalidad de estas formaciones pluriverbales en dos diccionarios: uno que versa sobre la lengua general como es el DRAE y otro de carácter fraseológico, el Diccionario de locuciones y expresiones familiares. Para realizar este análisis contrastivo de carácter diacrónico confrontamos la totalidad de nuestro corpus con la base de datos denominada corpusdelespanol.org. Ello nos permite ver y comparar el uso, así como la frecuencia de cada locución en el transcurso de los siglos XIX y XX.
La intertextualidad (1967-2007). El largo periplo de un término teórico
Authors: MONTES DONCEL Rosa E. , REBOLLO ÁVALOS María José
Published: February 2023

«Intertextualidad» es un término difundidísimo en Teoría Literaria que nace en 1967, acuñado por Julia Kristeva, que se ha utilizado desde entonces con diversos significados y que hoy sigue gozando de gran vigencia. El articulo intenta arrojar luz sobre la cuestión ordenando las acepciones otorgadas a la voz «intertextual» en los distintos autores o escuelas: dimensión marxista (la propia Kristeva y Bajtin), dimensión formal (Genette, Plett, Martínez Fernández o Segre), el uso cibernético de «hipertexto» en Nelson, etcétera. Aportamos profusos ejemplos, reflexiones sobre el papel que puede cumplir este fenómeno, sobre su consideración en diferentes épocas y sobre sus límites con el plagio.
Terminología y tesauros: la traducción jurídica de contract, agreement y treaty
Authors: LOBATO PATRICIO Julia
Published: February 2023

El presente articulo, ofrece un estudio terminológico dentro del campo especializado de la traducción jurídico-económica en la combinación lingüística inglés-español. Se realiza un análisis de la organización del conocimiento que ofrecen los tesauros de los organismos institucionales para los términos contract, agreementy treaty para concluir en una propuesta de traducción de los términos específicos y topes que se relacionan con los términos en cuestión.
Cruzar la frontera: un acto de traducción
Authors: LÓPEZ PONZ María
Published: February 2023

Las fronteras, aunque creadas para separar, acaban funcionando como zonas porosas que permiten el paso de influencias de un lado al otro. De esta forma, son un terreno propicio para el nacimiento de identidades y lenguajes híbridos. Prueba de ello es, por ejemplo, el límite entre México y Estados Unidos. Así, cruzar la frontera es más que un acto físico, dado que se convierte en un hecho cargado de connotaciones y de consecuencias. Pasar el límite puede ser, como analizaré en este articulo, un acto de traducción en el que, a menudo, el sujeto ha de trasladarse a si mismo en todos los aspectos.
La inspiración bíblica: Guillaume du Bartas y su influencia en Anne Bradstreet
Authors: GARCÍA CALDERÓN Ángeles
Published: February 2023

Trabajo que analiza la obra del poeta francés hugonote Du Banas, que escribió en 1578 un poema épico de 6000 alejandrinos inspirado en el Génesis: La Première Sepmaine ou la Création du monde; se trata de un tipo de poesía científica que incluye toda la ciencia cosmológica del Renacimiento y que tendrá una enorme difusión en la Europa de su época, influyendo notablemente en la obra de la poetisa inglesa emigrada a América, Anne Bradstret.
La traducción como vehículo de ideologías: aportaciones desde los diferentes enfoques traductológicos
Authors: RUIZ YEPES Guadalupe
Published: February 2023

Los conceptos de ideología y discurso no pueden estudiarse adecuadamente desde una sola perspectiva: requieren un análisis en todas las disciplinas de las humanidades y las ciencias sociales, es decir, deben estudiarse desde un marco multidisciplinar. Por este motivo se ha estudiado dicha relación desde disciplinas tales como la hermenéutica, la lingüística cognitiva, la lingüística contrastiva, la pragmática, la psicolingüística, la retórica/estilística, la semántica, la semiótica y la sociolingüística. Ahora bien, si el lenguaje es vehículo de ideologías, la traducción que es una actividad eminentemente lingüística también lo será. En este articulo describiremos brevemente las corrientes de investigación dentro de los Estudios de Traducción que se han ocupado de este fenómeno, tales como, el Funcionalismo, la Escuela de la Manipulación, las Teorías post-coloniales de la traducción, el Feminismo, el Análisis Critico del Discurso, etc., para comprobar si han logrado su objetivo de desenmascarar la relación entre ideología y traducción.
Genome-Wide Association Studies and fine-mapping of
genomic loci for n-3 and n-6 Polyunsaturated Fatty Acids in
Hispanic American and African American Cohorts
Authors: Yang Chaojie , Veenstra Jenna , Bartz Traci , Pahl Matthew , Hallmark Brian , Chen Yii-Der Ida , Westra Jason , Steffen Lyn , Brown Christopher , Siscovick David , Tsai Michael , Wood Alexis , Rich Stephen , Smith Caren , O'Connor Timothy , Mozaffarian Dariush , Grant Struan , Chilton Floyd , Tintle Nathan , Lemaitre Rozenn , Manichaikul Ani
Published: February 2023

Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) play critical roles in human health. Prior genome-wide association studies (GWAS) of n-3 and n-6 PUFAs in European Americans from the CHARGE Consortium have documented strong genetic signals in/near the FADS locus on chromosome 11. We performed a GWAS of four n-3 and four n-6 PUFAs in Hispanic American (n = 1454) and African American (n = 2278) participants from three CHARGE cohorts. Applying a genome-wide significance threshold of P < 5 x 10− 8, we confirmed association of the FADS signal and found evidence of two additional signals (in DAGLA and BEST1) within 200 kb of the originally reported FADS signal. Outside of the FADS region, we identified novel signals for arachidonic acid (AA) in Hispanic Americans located in/near genes including TMX2, SLC29A2, ANKRD13D and POLD4, and spanning a > 9 Mb region on chromosome 11 (57.5Mb ~ 67.1Mb). Among these novel signals, we found associations unique to Hispanic Americans, including rs28364240, a POLD4 missense variant for AA that is common in CHARGE Hispanic Americans but absent in other race/ancestry groups. Our study sheds light on the genetics of PUFAs and the value of investigating complex trait genetics across diverse ancestry populations.
Sensing of Disinfection Byproducts; An Iodo-Functionalized Metal-Organic Framework as a Platform
Authors: Amani Vahid , Norouzi Fataneh
Published: February 2023

A systematic sensing of halogenated disinfection byproducts (DBPs) has been studied for the first time in a un-/ functionalized UiO-67 MOFs. In this regard, an iodo-functionalized UiO-67 type metal-organic framework (MOF) (UiO-67(I)2) has been successfully synthesized via solvothermal reaction. The results show that the sensing response of the MOFs toward halogenated DBPs significantly increased by incorporation of halogen bonding (XB) functionalities. Noteworthy, in each class of DBPs, the sensing response of the considered MOFs regularly improved by moving from fluoro to iodo group; which precisely indicates that halogen bonding is in charge.
The impact of SnMnO2 TCO and Cu2O as an HTL on CIGSSe solar cell performance improvement
Authors: kumar Raushan , Priyadarshi Alok
Published: February 2023

This paper has simulated two experimental CIGSSe thin-film solar cells (TFSCs) having a high efficiency of 20% and 22.92%. Later validates the photovoltaics results of both devices based on the experiential values of optoelectronics data. After the simulation, a compelling result was confirmed for both the experimental and simulation solar cells. Finally, different designs have also been proposed. The proposed Type-1 solar cell is designed by the addition of low resistivity, wide energy bandgap (Eg), and minimum absorption coefficient (α) based tin-doped manganese oxide (Sn1 − xMnxO2) material in a conventional solar cell instead of ZnO: B and ZnMgO: Al transparent conducting oxides (TCO) layer. Further, by matching the band energy alignment and adjusting the thickness and doping concentration of the TCO, buffer, and absorber layers, the efficiency of the proposed Type-1 TFSC has been increased from 20 to 27.75%. The proposed Type-1 solar cell has some drawbacks, such as the inability to appropriately suppress the photogenerated minority carrier recombination losses due to the absence of a hole transport layer (HTL), and the EQE is relatively lesser than the conventional solar cell. Furthermore, wide band energy and a high ‘α’ based on cuprous oxide (Cu2O) as a HTL are added between the absorber and the back ohmic contact layers in the proposed Type-1 solar cell. Then the structure becomes a proposed Type-2 TFSC. The proposed Type-2 TFSC absorbs more blue light, instantly suppressing the recombination losses and enhancing efficiency (29.01%) and EQE (97%).
Antagonistic fatigue crack propagation in Ni-based superalloy 718 under hydrogen-supply: Acceleration and deceleration phenomena
Authors: Takakuwa Osamu , Ogawa Yuhei , Miyata Ryunosuke
Published: February 2023

Mechanical properties of structural alloys, including Ni-based superalloy 718 (Alloy718), are degraded when hydrogen (H) is supplied: hydrogen embrittlement (HE). The presence of H notably deteriorates fatigue crack growth (FCG) property, which renders the growth rate much higher and shortens the lifetime of the components operating in the hydrogenating environment. Hence, the mechanisms behind such acceleration phenomenon in FCG should be understood comprehensively toward developing promising alloys resistant to hydrogen occlusion. In particular, Alloy718 has a meager resistance to HE, even regularly displaying superior mechanical and physical performances. Notwithstanding, the present study unveiled that the FCG acceleration by dissolved H in Alloy718 can be negligible. An abnormal deceleration of FCG can instead be pronounced by optimizing the metallurgical state, a hopeful prospect in Ni-based alloys applied to the hydrogenating environment.
Different food coping strategies in urban and semi-urban areas during Coronavirus Disease 2019 (COVID-19) pandemic
Authors: Fikawati Sandra , Syafiq Ahmad , Notarianti Rizna , Gemily Syilga Cahya
Published: February 2023

Background: Consumption-related behavior implemented as an effort to maintain household food security is referred to as a food coping strategy (FCS). This study aims to describe the selection of FCS by families in urban and semi-urban areas in Indonesia.
Method: This research is a cross-sectional study with a total sample of 517 people who live in urban (Jakarta) and semi-urban (Depok) areas. The research data was taken from primary research data that had been collected online and purposively through Posyandu cadres who had access to family/community. Data analysis used the chi-square test and multiple logistic regression.
Results: More households in urban areas apply food security coping strategies (69%) compared to semi-urban areas (59.8%) In semi-urban areas, changes occur gradually from the lightest to the heaviest. Meanwhile, in urban areas, there were more severe strategies chosen, namely switching to other staple foods (78.7%), reducing eating in adults (75.3%), and reducing the frequency of eating (71.9% which is higher than reducing food portions (70, 2%). Results of multivariate analysis showed that the level of household food security (AOR = 12.182; 95% CI = 7.636 – 19.434) and spouse's education (AOR = 2.184; 95% CI = 1.091 – 4.375) were significantly related to the application of household FCS after being controlled by spouse's employment status, the number of working household members, household head’s education and household head’s income.
Conclusion: The low level of household food security during the COVID-19 pandemic and the impact of the COVID-19 pandemic on people's jobs and income have caused households to adapt by implementing several types of FCS.
Contrasting allelic effects for pistachio salinity tolerance in juvenile and mature trees
Authors: Sheikhi Abdollatif , Arab Mohammad , Palmer William , Michelmore Richard , Brown Pat
Published: February 2023

Breeding perennial tree crops often requires prediction of mature performance from juvenile data. To assess the utility of juvenile screens to predict salinity tolerance of mature pistachio trees, we compared performance of three-month ungrafted seedlings and four-year-old grafted rootstocks under salinity stress. The QTL allele associated with higher salt exclusion from seedling leaves conferred lower growth in saline field conditions, cautioning that mapping QTL in seedlings may be easier than discerning the optimal allele for field performance.
Predicting Rejection of Emerging Contaminants through RO Membrane Filtration based on ANN- QSAR Modeling Approach: Trends in Molecular Descriptors and Structures towards Rejections
Authors: Mousavi Setare Loh , Sajjadi Seyedeh Maryam
Published: February 2023

In this work, a quantitative structure-activity relationship (QSAR) study was performed on a set of emerging contaminants (ECs) to predict their rejections by reverse osmosis membrane (RO). A wide range of molecular descriptors was calculated by Dragon software for 72 ECs. The QSAR data was analyzed by an artificial neural network method (ANN), in which four out of 3000 descriptors were chosen and their significance was computed. The significance trends of descriptors were as follows in descending order: ESpm14u > R2e > SIC1 > EEig03d. For the first time, an explorative study was conducted on the QSAR data to show the trends in molecular descriptors and structures toward the rejections values of ECs. Moreover, the MLR algorithm was used to make a linear model and the results were compared with those of the nonlinear ANN algorithm. The comparison results revealed it is necessary to apply the ANN model to this data with non-linear properties.
Bayesian modelling of response to therapy and drug-sensitivity in acute lymphoblastic leukemia
Authors: Cremaschi Andrea , Yang Wenjian , De Iorio Maria , Evans William , Yang Jun , Rosner Gary
Published: February 2023

Acute lymphoblastic leukemia (ALL) is a heterogeneous haematologic malignancy involving the abnormal proliferation of immature lymphocytes and accounts for most paediatric cancer cases. The management of ALL in children has seen great improvement in the last decades thanks to greater understanding of the disease leading to improved treatment strategies evidenced through clinical trials. Common therapy regimens involve a first course of chemotherapy (induction phase), followed by treatment with a combination of anti-leukemia drugs. A measure of the efficacy early in the course of therapy is the presence of minimal residual disease (MRD). MRD quantifies residual tumor cells and indicates the effectiveness of the treatment over the course of therapy. MRD positivity is defined for values of MRD greater than 0.01%, yielding left-censored MRD observations. We propose a Bayesian model to study the relationship between patient features (leukemia subtype, baseline characteristics, and drug sensitivity profile) and MRD observed at two time points during the induction phase. Specifically, we model the observed MRD values via an auto-regressive model, accounting for left-censoring of the data and for the fact that some patients are already in remission after the first stage of induction therapy. Patient characteristics are included in the model via linear regression terms. In particular, patient-specific drug sensitivity based on ex vivo assays of patient samples is exploited to identify groups of subjects with similar profiles. We include this information as a covariate in the model for MRD. We adopt horseshoe priors for the regression coefficients to perform variable selection to identify important covariates. We fit the proposed approach to data from three prospective paediatric ALL clinical trials carried out at the St. Jude Children’s Research Hospital. Our results highlight that drug sensitivity profiles and leukemic subtypes play an important role in the response to induction therapy as measured by serial MRD measures.
Is MCC950, an NLRP3 inflammasome inhibitor, a renopreventive: A chronic renal failure adenine model in rats
Authors: Sabra Mahmoud S. , Hemida Fahmy K. , Allam Essmat A.H.
Published: February 2023

Background: Chronic renal failure (CRF) is characterized by a great loss in renal function ending with reduced sodium filtration and suppression of tubular reabsorption that eventually leads to volume expansion. The contradictory information on the MCC950 renal effects brought this study to evaluate the possible renopreventive effects of NLRP3 inflammasome inhibitor MCC950 in adenine-induced CRF in rats.
Methods: Adding 0.75% of adenine powder to a rat’s ration daily for 4 weeks is measured as a broad approval to be a model of evaluation of kidney damage as it is similar to most of the kidney tubular alterations seen in chronic kidney-diseased patients. Blood pressure was monitored at baseline and weekly during the test. Also, oxidative stress factors, urine sample analysis, histopathological changes, and immunohistochemical alterations of caspase-3 and interleukin-1 beta (IL-1β) levels in renal tissues were done.
Results: Results showed that the NLRP3 inflammasome inhibitor MCC950 had a renopreventive effect that was established by a decrease in blood pressure measurements, and improvement of urinary, serum, and renal tissue markers as revealing organ damage. This was also revealed by the reduction of tubular expression of neutrophil gelatinase-associated lipocalin (NGAL).
Immunohistochemical studies revealed that the worsened renal cellular changes indicated by raised expression of caspase-3 and IL-1β were prominently improved by NLRP3 inflammasome inhibitor MCC950 administration.
Conclusion: The NLRP3 inflammasome inhibitor MCC950 administration in the CRF rat model had renopreventive effects which may be a potential therapeutic approach to prevent the progression of CRF.
Starch-dependent sodium accumulation in the leaves of Vigna riukiuensis.
Authors: Noda Yusaku , Hirose Atsushi , Wakazaki Mayumi , Sato Mayuko , Toyooka Kiminori , Kawachi Naoki , Furukawa Jun , Tanoi Keitaro , Naito Ken
Published: February 2023

This research provides insight into a unique salt tolerance mechanism of Vigna riukiuensis. V. riukiuensis is one of the great genetic resources of salt tolerance. We have previously reported that V. riukiuensis accumulates a higher amount of sodium in the leaves, whereas V. nakashimae, a close relative of V. riukiuensis, suppresses sodium allocation to the leaves. We first suspected that V. riukiuensis would have developed vacuoles for sodium sequestration, but there were no differences compared to a salt-sensitive accession. However, many starch granules were observed in the chloroplasts of V. riukiuensis. In addition, forced degradation of leaf starch by shading treatment resulted in no radio-Na (22Na) accumulation in the leaves. We performed SEM-EDX to locate Na in leaf sections and detected Na in chloroplasts of V. riukiuensis, especially around the starch granules but not in the middle of those. Our results could provide the second evidence of Na-trapping system by starch granules, following the case of common reed that accumulates starch granule at the shoot base for binding Na.
Familial dysalbuminemic hyperthyroxinemia combined with Graves’ disease: A case report and literature review
Authors: Li Yuanmeng , Chi Yue , Chai Xiaofeng , Liu He , Li Naishi , Lian Xiaolan
Published: February 2023

Background: Familial dysalbuminemic hyperthyroxinemia (FDH) is a dominantly inherited disease characterized by abnormally increased affinity of albumin for serum thyroxine. Assay interference and differential diagnosis remain challenges for FDH. The condition becomes more complicated when FDH combined with primary thyroid diseases. The co-occurrence of FDH and Graves’ disease is one of the rare cases.
Case presentation: We reported a 28-year-old woman with a complex condition of FDH coexisted with Graves’ disease. The existence of FDH was not recognized at first. And the Graves’ disease was relieved after treatment with antithyroid drugs and two times of radioactive iodine therapy. Then she developed to primary hypothyroidism and received levothyroxine replacement. But the thyroid function failed to reach normal despite of frequent adjustment of levothyroxine. Finally, syndromes of inappropriate secretion of thyroid stimulating hormone (IST) were considered and FDH was successfully distinguished from other causes of IST.
Conclusions: More attention should be paid to FDH when investigating the causes of IST. Early recognition of FDH is critical to rightly evaluate the thyroid function status and avoid inappropriate treatment, especially in complicated cases with concurrent FDH and primary thyroid diseases.
Prenatal Genetic Analysis of Kidney Abnormalities
Authors: Shen Yongmei , Li Yaqi , Zhao Xiaomin , Li Wen , Zhang Lei , Yao Liying , Cao Jiasong , Li Shanshan , Wei Zhuo , Chang Ying
Published: February 2023

Objective: To systematically analyze the genetic features of fetal renal abnormalities and the prenatal characteristics of 17q12 microdeletion syndrome.
Methods: We retrospective analysis of fetal diagnosed with renal abnormalities from January 2016 to August 2022. Chromosome test, fetal renal abnormalities and pregnancy outcomes were performed in a descriptive analysis.
Results: 141 patients (4.5%) showed abnormal renal development and 26 patients (26/141) with hyperechogenic kidneys (HCK), 14 (14/26) cases showed chromosomal abnormalities, 12 patients were 17q12 microdeletion syndrome. In addition, there were 14 17q12 microdeletion syndrome among the patients, and 12 fetal had hyperechogenic kidneys (HCK), 7 fetal were verified by couples, 5 fetal had new mutations, and 2 fetal inherited from parents. After excluding patients with HCK, the polycystic kidney has a higher rate of chromosomal abnormalities compared to polycystic renal dysplasia and renal dysplasia. The chromosomal of isolated horseshoe kidney, hydronephrosis, ectopic kidney and unilateral kidney often were normal, and the chromosomal abnormalities rate was increased when combined with other abnormalities.
Conclusion: Fatal HCK was closely related to 17q12 microdeletion syndrome. The chromosome test result of patients with isolated polycystic kidney dysplasia, kidney dysplasia, horseshoe kidney, hydronephrosis, kidney deficiency, and ectopic kidney were mostly normal. Prenatal diagnosis was recommended, specifically in the fetus had non-isolated renal abnormalities. Most patients with normal chromosomes or uncertain clinical significance choose to produce, but adverse pregnancy outcomes were not excluded. This study will provide more data support for fetal renal abnormalities.
Synergic quantum generative machine learning
Authors: Bartkiewicz Karol , Tulewicz Patrycja , Roik Jan , Lemr Karel
Published: February 2023

We introduce a new approach towards generative quantum machine learning significantly reducing the number of hyperparametersand report on a proof-of-principle experiment demonstrating our approach. Our proposal depends on collaboration betweenthe generators and discriminator, thus, we call it quantum synergic generative learning. We present numerical evidence thatthe synergic approach, in some cases, compares favorably to recently proposed quantum generative adversarial learning.In addition to the results obtained with quantum simulators, we also present experimental results obtained with an actualprogrammable quantum computer. We investigate how a quantum computer implementing generative learning algorithm couldlearn the concept of a maximally- entangled state. After completing the learning process, the network is able both to recognizeand to generate an entangled state. Our approach can be treated as one possible preliminary step to understanding how theconcept of quantum entanglement can be learned and demonstrated by a quantum computer.
Gastrointestinal parasites of zoonotic importance detected in porcine faeces in Chitwan National Park, Nepal
Authors: Subedi Janak Raj , Neupane Sanskar , Dhakal Pitambar
Published: February 2023

Wild boar (Sus scrofa) is considered to be a potential source of zoonotic parasites. Wild boars are found at considerable number in and around the Chitwan National Park (CNP). The information regarding their intestinal parasites is limited. A cross-sectional study was carried out to determine the prevalence of gastrointestinal parasites in wild boars in CNP. A total of 100 fresh fecal samples were subjected to microscopic examination using direct smear, floatation and sedimentation method. Overall, 95% fecal samples were found positive for at least one parasite. Prevalence of protozoan parasites was found comparatively higher (70%) followed by nematode (56%) and trematode (12%). Nine gastrointestinal parasites Eimeriasp. (70% without micropyle and 40% with micopyle), Fasciola sp. (12%), Strongyloides sp. (56%), Strongyle type (49%), Stephanurus sp. (44%), Globocephalus sp. (38%), Metastrongylus sp. (12%), Ascaris sp. (7%) and Trichuris sp. (6%).) were recorded. Eimeria sp. exhibited the highest prevalence while Trichuris had the least prevalence. This study has provided baseline information regarding the diversity of gastrointestinal parasite in wild boars. It requires continuous study at molecular level to explore other species of parasites and verify their zoonotic potential.
Informational active matter
Authors: VanSaders Bryan , Vitelli Vincenzo
Published: February 2023

Many biomolecular systems can be viewed as ratchets that rectify environmental noise through measurements and information processing. As miniaturized robots cross the scale of unicellular organisms, on-board sensing and feedback open new possibilities for propulsion strategies that exploit fluctuations rather than fight them. Here, we study extended media in which many constituents display a feedback control loop between measurement of their microstates and the capability to bias their noise-induced transitions. We dub such many body systems informational active matter and show how information theoretic arguments and kinetic theory derivations yield their macroscopic properties starting from microscopic agent strategies. These include the ability to self-propel without applying work and to print patterns whose resolution improves as noise increases. We support our analytical results with extensive simulations of a fluid of `thinker' type particles that can selectively change their diameters to bias scattering transitions. This minimal model can be regarded as a non-equilibrium analogue of entropic elasticity that exemplifies the key property of this class of systems: self-propulsive forces grow ever stronger as environmental noise increases thanks to measurements and control actions undertaken by the microscopic constituents. We envision applications of our ideas ranging from noise induced patterning performed by collections of microrobots to reinforcement learning aided identification of migration strategies for collections of organisms that exploit turbulent flows or fluctuating chemotactic fields.
Analysis and Assessment of Ground Motion Characteristics and Similarity Using Dynamic Time Warping Distance
Authors: He Haoxiang , Sun Haoding , Chen Yifei
Published: February 2023

Due to the complex nonstationarity of ground motion in time-frequency domain, the traditional methods of comparing and evaluating earthquake waveforms have not enough ability and accuracy to distinguish the details and changing features of the similar waves, which makes the similarity evaluation of waveform is difficult to be quantified accurately. The similarity degree of different signals can be calculated precisely according to Dynamic time warping (DTW) algorithm, so it can be used for waveform comparison and similarity evaluation. In order to improve the traditional method, a method based on DTW distance is proposed to identify the earthquake waveform and analyze the ground motion characteristics. Based on the statistical analysis of a great quantity of earthquake waves, the changes law of DTW distance considering amplitude, time lag, noise signal ratio, site type and the comprehensive effect is obtained. DTW distance is proved to be used as a compatible evaluation standard for waveform refinement. It is verified that DTW distance and vector norm are essentially equivalent. In the analysis of ground motion, DTW distance is implicated in the equivalent amplitude and energy of earthquake waves. The physical connotation of DTW distance is demonstrated by analyzing the data of the station array, and the results show that the distribution of DTW distance can accurately imply the time-space variation effect of the earthquake in the region. The reasonable reference range of DTW distance is defined by statistical method, and the corresponding evaluation standard of synthetic multi-point ground motion with real characteristics is proposed. In the synthetic accuracy evaluation of artificial ground motion with spatial variation effect, the combination of ground motions with more real characteristics can be obtained by evaluating and optimizing the waveforms according to the variation rule and range of DTW distance.
Fear of cancer Recurrence Despite a good prognosis: A Qualitative study with Thyroid Cancer Patients
Authors: Lu Geling , Luo Weixiang , Lin Junqing , Xu Nan , Zheng Chunrao
Published: February 2023

Objective: Thyroid cancer’s emotional and mental toll is often beyond the disease’s duration. The fear of cancer recurrence (FCR) was prominent among cancer patients and survivors, but there are few studies on this population. This study aims to explore the experience of FCR and expand understanding of FCR in patients with thyroid cancer.
Methods: In this qualitative study, 18 patients with thyroid cancer were included via semi-structured interview. The average age of the respondents is 41-year-old, and the average time since diagnosis is 2 years.
Results: In the process of exploring the experience of FCR in thyroid cancer patients, the following three themes have emerged: First, "uncertainty of disease" refers to the uncertainty in face of cancer. Most of the participants are committed to trying to return to the state before diagnosis. The second is the "triggers for FCR", which involves internal and external factors. The third is the diversification of FCR management, which included fatalism and active response to seek help.
Conclusions: The fear of cancer recurrence in thyroid cancer patients needs further understanding. Medical staff can reduce or buffer FCR in thyroid cancer patients by treating triggers and strengthening positive changes.
Sodium hydrogen sulfide alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via the inhibition of the ubiquitination and degradation of IKB-α
Authors: Fei Wenchao , Tong Wenqin , Xu Ke , Huo Ziqi , Hong Yang , Li Yinghua
Published: February 2023

Background: Although several effective therapies are available for the treatment of postmenopausal osteoporosis (PMO), the most common type of primary osteoporosis (OP). More effective and acceptable drugs to cure postmenopausal osteoporosis were needed. NaHS, the donor of H2S, may be one of the drugs to treat PMO, but its role and mechanism are still unclear.
Methods：Ovariectomized mice and Sham operation mice, BMMs and RAW264.7 cell lines were used to illustrate the in vivo and in vitro effects of NaHS on the osteoclast differentiation. On the other hand, molecular and histological methods were applied to evaluate the osteoclast differentiation and investigate the in vivo and in vitro mechanism.
Results: Phenotypically, NaHS treatment can increase the bone mineral density and bone quality of osteoporosis models induced by ovariectomy (OVX) in mice. Mechanistically, NaHS inhibited the nuclear translocation of p65 by inhibiting the ubiquitination and proteasome degradation of IkB-α.
Conclusions: NaHS protects against OVX-induced bone loss by inhibiting osteoclastic bone resorption. It plays an important role in inhibiting osteoclast differentiation and protecting against bone loss in PMO and it is potential for preventing and treating PMO.
Synergistic effects of miR-143 with miR-99a inhibited cell proliferation and induced apoptosis in breast cancer
Authors: Doosti Zahra , Ebrahimi Syed Omar , Ghahfarokhi Mahshid Samie , Reiisi Somayeh
Published: February 2023

Introduction: Breast cancer (BC) is the most common cancer type and the fifth leading cause of cancer-related death. The primary goals of BC treatment are to remove the tumor and prevent metastasis. Despite advances in BC treatment, more effective therapies are required. miRNAs can regulate many targets involved in biological processes and tumor progression; these molecules have emerged as a promising cancer treatment strategy. In the present study, we investigated the effects of miR-99a and miR-143 in based single expression plasmids for BC inhibition.
Methods: In this study, the precursor structure of miRNAs in the expression vector pEGFP-N1 entered single and double states, and MCF7 and T47D cells were transfected. The miRNAs expression level after transfection was then measured using qPCR. The MultiMiR package was used to obtain predicted and validated miRNA targets. MTT assay, qRT-PCR, migration test, and flow cytometry were used to assess the effect of miRNA and gene modulation.
Results: The qPCR results revealed that miRNA constructs were significantly expressed after the transfection of both cell lines. The biological function of miRNAs showed that upregulation of miR-99a and miR-143 in any of the two selected BC cells inhibited their proliferation and migration rate, significantly inducing apoptosis (p<0.01). Also, miR-99a/-143 co-treatment has a synergistic anticancer effect in cancer cells via Akt1 and CDK6 targeting.
Conclusion: These findings suggest that miR-99a/-143 plays synergistic regulatory roles in BC, possibly via a shared signaling pathway, providing a therapeutic strategy for BC treatment.