bluuebunny/crossref_metadata_2025 huggingface dataset:
Golden Gate Assembly v1
Authors: Núñez Isaac , Matute Tamara , Federici Fernan
Published: April 2022

The Golden Gate technique allows the assembly of genetic sequences from libraries of standardized basic components, which are cleaved from their donor vectors and concatenated in the acceptor vector in a defined order. This reaction is subsequently transformed into competent bacterial cells that are grown overnight to reveal positive colonies carrying the correctly assembled vector. The cleavage of the components is done by a TypeIIS restriction enzyme, which recognizes asymmetric DNA sequences and cleaves outside of this site, leaving overhangs in a directional way (Figure 1A). This property allows the creation of ordered assembly positions by defining synthetic syntaxes of these overhangs (Figure 1B). Within the different methodologies and libraries based on Golden Gate, some methods, such as uLoop Assembly (Pollak et al, 2020), allow the cyclic assembly of increasingly large and complex vectors in which the products of a reaction are the substrates of the next level reactions (Figure 2). By this means it is possible to build libraries of easily reusable components to perform assemblies in a combinatorial way of odd and even assembly levels. The standardized DNA components have to be flanked by the enzyme recognition sites and the proper syntax according to the desired position of assembly. These DNA pieces can be obtained from previously created libraries or custom made. The reaction operates cycling between 37°C and 16°C. At the first temperature, the restriction enzyme cuts the DNA pieces. These pieces are concatenated by their overhangs sequence homology and sealed by the catalysis of a ligase enzyme at the second temperature. Once a piece is correctly assembled it cannot be cutted again, and cycle by cycle, the pieces are concatenated in the final assembly product.
Imaging an Underwater Basin and Its Resonance Modes Using Optical Fiber Distributed Acoustic Sensing
Authors: Lior Itzhak , Mercerat E. Diego , Rivet Diane , Sladen Anthony , Ampuero Jean-Paul
Published: April 2022

Distributed acoustic sensing (DAS) is an ideal tool for ambient noise tomography owing to the dense spatial measurements and the ability to continuously record in harsh environments, such as underwater. Although the fine spatial sampling of DAS facilitates the imaging of small-scale lateral velocity heterogeneities, efforts relying on dispersion-based ambient noise tomography are hampered by the underlying premise of negligible lateral variations across the segment used for dispersion curve extraction. To image small-scale structures, this method should be augmented with objective and independent approaches that are not scale limited. Here, we show that power spectral densities (PSDs) and autocorrelations (ACs) of DAS data reveal extremely detailed frequency-dependent resonance and wave propagation characteristics. These observations contain crucial information on lateral and vertical wave propagation. We use these methods to demonstrate the ability to image a complex underwater basin using ambient noise recorded on a fiber deployed offshore Greece. A 2D shear-wave velocity model was derived by analyzing Scholte-wave dispersion. The PSD and AC reveal significant lateral variations across the short 2.5 km long fiber segment, including basin edge effects and scattered waves. These were used to further constrain and modify the velocity model. The modified model is supported by waveform simulations that qualitatively reproduce the PSD and AC observations. Our results demonstrate the advantages of incorporating PSD and AC observations into ambient noise-based imaging. The spatially continuous observation of resonance modes across the basin highlights the benefit of DAS acquisitions for ground-motion estimation.
Acantholytic squamous cell carcinoma: Pathological study of three cases in Ecuador
Authors: Aldas Eduardo Garzón , Torres Gabriela
Published: April 2022

Adenoid squamous cell carcinoma is an uncommon histopathological variant of squamous cell carcinoma characterized by acantholysis of tumor cells creating pseudolumina and the appearance of glandular differentiation. It is also known as pseudoglandular, pseudoangiosarcomatous, adenoid, epithelioma dyskeratoticum, or adenoacanthoma. In this article, we describe and analyze three cases of acantholytic cell carcinoma. The purpose is to verify if the data of our cases can be validated with scientific information. All our cases presented lesions in the face, and in one of them the developed tumor on the skin showed actinic keratosis. The other two tumors were located in the right side of the face, and both were big: the bigger tumor was approximately 8 × 4 cm and the other one with a size of 6 × 2.5 cm. Due to the size and location, they were both send to the oncologist for treatment. One of our cases showed metatypical carcinomas accompanied by acantholytic variant of squamous cell carcinoma. None of our cases presented metastasis. The histopathological finding were keratinized squamous tumor cell type, adenoid structures with round spaces with a defined wall of at least one-cell width, and spaces with isolated or group of dyskeratotic cells.
Chemical peeling as a treatment of melasma
Authors: Aghaei Shahin
Published: April 2022

Melasma, which is derived from the Greek word “Melas” (black) is an acquired, symmetrical and macular pigmentation of exposed areas of skin including cheeks, upper lip, chin, nose and forehead. Although it is much more common in skin of color, any race could be affected. Most of cases are women during their reproductive years.
Evidence of incompatibility for topical anionic agents used in conjunction with chlorhexidine gluconate: A systematic review
Authors: Tran Gary , Huynh Thy N , Bruins Finola M , Ahmad Najeah , Budris William A , Posligua Alba , Hammel Josh A , Nardone Beatrice , West Dennis P
Published: April 2022

Chlorhexidine gluconate (CHG) is a widely used antiseptic agent for skin and wound disinfection. The cationic properties of CHG may allow its inactivation and precipitation by anionic agents in commonly used topical agents. We conducted a systematic review by searching through PubMed, Cochrane Library, and Web of Science databases and selected original research articles reporting on CHG incompatibility, defined as inactivation or precipitation. The search yielded 22 publications that demonstrated CHG incompatibility via: 1) reduced antibacterial activity (carbomer, acrylates/C10-C30 alkyl acrylate crosspolymer, dentin, bovine serum albumin, copolymer M239144, sodium lauryl sulfate, heat-killed microbes, triethanolamine, and bark cork); and 2) visible precipitate formation (sodium hypochlorite, EDTA, saline, ethanol, andnystatin). Only three publications reported on CHG incompatibility in dermatology, specifically for carbomer, triethanolamine, and acrylates/C10-C30 alkyl acrylate crosspolymer. Although limited evidence linking CHG incompatibility and anionic agents exists, clinicians should carefully consider the nature of topical agents used if CHG is concurrently applied. Increased awareness of CHG incompatibility may result in better antibacterial activity thus ensuring optimal patient management.
Fiddler’s neck: Cultural influences modify clinical presentation influences
Authors: Chowdhry Sundeep , Chand Sameeksha , D'Souza Paschal
Published: April 2022

Fiddler’s neck which is also referred to as a “violin hickey” is a benign dermatologic occupational disease associated with the use of certain instruments like the violin, viola, cello etc. It is believed to be a type of allergic contact dermatitis, manifesting as an acute or chronic eczematous lesion typically at the submandibular and/or supraclavicular region on the side of neck. It can present as erythema, oedema and/or vesicles in the acute stage and as scaling, lichenification, hyperpigmentation and scarring in the chronic stage. Acne mechanica has also been considered by some authors as a presentation of fiddler’s neck. Occasionally, there may be associated swelling redness or a cystic lesion that makes it difficult to differentiate from lymphedema or a salivary gland tumor. PubMed search for articles about this entity resulting in instrument-induced dermatitis yielded few results of this forgotten entity which mimics a love bite (love hickey). For diagnosis, history of the usage of a string instrument which is held between the shoulder and neck, local physical examination and a positive patch test are pre-requisites. Management of fiddler’s neck includes application of topical mild steroid, emollient, proper instrument handling, neck padding, changing the material and polish of the instrument, and/or reducing the amount of playing time. Surgical intervention is usually not advisable unless cystic or tumorous lesions are the manifesting feature. The authors intend to revisit this entity and report an improvised modality that is being used by these instrumentalists in India which may help in prevention of this condition.
Drexel w Polsce (XVII-XVIII wiek). Rekonesans
Authors: Pawlak Wiesław
Published: April 2022

Artykuł dotyczy polskiej recepcji twórczości niemieckiego jezuity Jeremiasa Drexela (1581-1638), twórcy popularnych w całej niemal Europie łacińskich pism o tematyce religijnej i moralistycznej. Autor przedstawia korpus XVII- i XVIII-wiecznych polskich translacji dzieł Drexela (autorstwa m.in. Jana Chomętowskiego, Szymona Jurkiewicza, Albrychta Stanisława Radziwiłła i Kazimierza Stęplowskiego), rejestruje ich obecność w księgozbiorach przedrozbiorowej Rzeczypospolitej oraz liczne świadectwa ich odbioru w tekstach polskich twórców, przede wszystkim w piśmiennictwie kaznodziejskim i religijnym, wskazuje możliwe kierunki przyszłych badań (np. nad strategiami translatorskimi staropolskich tłumaczy) oraz podkreśla rolę literatury nowołacińskiej w transferze kulturowym między dawną Rzecząpospolitą a krajami niemieckiego obszaru językowego oraz w przełamywaniu barier etnicznych, politycznych i wyznaniowych we wczesnonowożytnej Europie.
Jan Hus na ambonie. Między praktycyzmem a wiarą
Authors: Bracha Krzysztof
Published: April 2022

Postać Jana Husa w historii średniowiecznych Czech ma wymiar absolutnie wyjątkowy, a jego życie i dzieło wykracza daleko poza czeski kontekst. Tematyka husycka urosła do rangi odrębnej specjalności w międzynarodowej mediewistyce. Jan Hus doczekał się dotychczas kilku biografii, a najnowsza praca P. Soukupa, nie będzie zapewne ostatnią. Spośród dotychczasowych wyróżnia ją szczególne podkreślenie roli ambony i kaznodziejskiej aktywności Husa, co odzwierciedla także tytuł książki. Dla Husa ambona stała się bowiem podstawowym narzędziem promocji idei reformatorskich. Podstawowym zatem zagadnieniem staje się pytanie o podłoże wyboru kazalnicy, które zdeterminowało życie czeskiego reformatora. Punktem zwrotnym stała się aktywność Husa na ambonie Kaplicy Betlejemskiej. P. Soukup podkreśla przede wszystkim praktycyzm ambony, jedynego mass medium zdolnego do propagacji treści ideowych, i słusznie Kaplicę Betlejemską nazywa „a unique center of reform”. Dodajmy jednak do wywodów autora, że Hus wybrał ambonę nie tylko z powodów praktycznych, lecz w równym stopniu ideowych. Wybór ambony przez Husa, to przekonanie o skuteczności kazań, o sile słów i performacyjnej funkcji mowy. Hus w swych kazaniach przywoływał przewodnią metaforę kazania, jaką znamy z dokumentu fundacji Kaplicy Betlejemskiej, a mianowicie słowa Bożego jako nasienia (semen, semeno, sieme). W przeciwieństwie do mszy tylko godne kazanie sprawia, że dusze niektórych jednoczą się w miłości z Chrystusem, pisał w jednym z kazań. Przyjęte ramy biografii nie sprzyjały szczegółowym uwagom. Śledzenie drogi życiowej Husa przez pryzmat aktywności kaznodziejskiej pozostaje jednak godną podkreślenia zasługą autora.
Struktury kościelne zachodniej Korony po pierwszym rozbiorze w świetle Szkiców Karola Perthéesa
Authors: Borek Arkadiusz
Published: April 2022

Szkice opracowane przez Karola Perthéesa stanowiły dla niego podstawę do przygotowania w końcu XVIII wieku map województw zachodniej Korony w granicach po pierwszym rozbiorze. Informacje w Szkicach pochodziły z ankiet parafialnych przygotowanych przez plebanów. Szkice zawierają m.in. wiadomości o strukturach terytorialnych Kościoła katolickiego. Ze względu na ich pośrednie pochodzenie od instytucji kościelnych można próbować je wykorzystać do rekonstrukcji struktur terytorialnych Kościoła. Ewaluacja informacji ze Szkiców na ten temat wskazuje jednak, że źródło to jest pod tym względem nierówne. Wynika to z faktu, że tylko informacje o parafiach i ich przynależności dekanalnej pochodzą zawsze bezpośrednio od Perthéesa (przez niego z ankiet parafialnych), a informacje o jednostkach wyższego rzędu często od osoby, która po śmierci Pertheesa opracowywała ten materiał, osoba ta nie posiadała jednak odpowiednich do tego kompetencji. Za wiarygodne w Szkicach można uznać informację o ponad 2050 parafiach, a te o jednostkach wyższego rzędu należy konfrontować z innymi źródłami.
What did the Rabbis know about grammar? Exegesis and grammatical gender in late antiquity
Authors: Williams Benjamin
Published: April 2022

The first systematic analyses of Hebrew grammar were composed by Rabbanite and Karaite scholars of the tenth and eleventh centuries, partly by drawing on the conventions of Arabic linguistics. However, certain technical grammatical terms, including the expressions
leshon zakhar
(‘masculine’) and
leshon neqevah
(‘feminine’), can be found in Midrashic and Talmudic texts. This article considers the grammatical knowledge underlying the rabbinic expositions. Points of comparison are sought in late-antique grammatical treatises and non-rabbinic interpretive works, including Philo’s commentaries and scholia on the
Iliad
and
Aeneid
, with particular attention to perceived relationships between grammatical gender and cultural gender norms. By differentiating this understanding of linguistic gender from those articulated in the commentaries and grammars of medieval Jewish scholars of the Muslim world, the article argues that the rabbinic expositions were shaped by grammatical concepts that are well attested in late-ancient Graeco-Roman textual scholarship.
The ʾāšām bûr (אשׁם בור): early-medieval Karaites, Leviticus 5:18b and the Masoretic text
Authors: Habib Joseph
Published: April 2022

The Masoretic text of Leviticus 5:18b appears to contain two different traditions of reading. One is reflected by a syntactic break via the pausal form שָׁגָ֛ג [
šāgāg
] ‘he sinned unintentially’. The other is reflected by a break after לֹֽא־יָדַ֖ע ‘he did not know’ via the Tiberian Masoretic accents. The interpretation of the reading reflected by the pausal form is well accounted for within traditional rabbinic literature. According to it, this verse requires an offering called the
ʾāšām tālûy
(אָשָׁם תָּלוּי) ‘Suspended Guilt Offering’. The interpretation of the reading reflected by the accents, however, has not yet been clarified or identified with any particular tradition. The commentaries of the early-medieval Karaites reflect an interpretation based on a division similar to that of the accents and therefore offer one possible way to understand that division.
Rabbinic–Muslim jurisprudence in medieval Andalusia
Authors: Stampfer Zvi
Published: April 2022

This article shows that the first rabbinic work exclusively devoted to the field of jurisprudence, which was written in Judaeo-Arabic in eleventh-century Andalusia by Rabbi David ben Sa̔adya, involved a ‘dialogue’ with contemporary Muslim scholars. Indeed, some of the terms used in the work can only be understood in the context of contemporary Islamic legal terminology, with the author assuming that his readers were well aware of the principles of Islamic law. Of particular interest is the author’s use of Islamic jurisprudence to reinterpret biblical verses and Talmudic discourses. This work – hidden for centuries – was preserved in the Cairo Genizah.
‘From my flesh I behold God.’ Circumcision and deconstruction: traces of Jacques Derrida
Authors: Ben Pazi Hanoch
Published: April 2022

One of the most remarkable ventures of the French philosopher Jacques Derrida is his unique exploration of the ‘covenant of circumcision’, which transforms the religious commandment and ceremony into a philosophical concept. Beyond the philosophical aspect of Derrida’s treatment of circumcision in his writings, his interest also conveys a particularly thought-provoking biographical element. Derrida addresses the rite of circumcision from his innermost self, rendering his engagement with the subject a combination of analysis, confession and reading. In this article I read Derrida’s interpretive endeavour, deconstruction, as a literary implementation of the concept of circumcision – not only the deconstructive interpretation he has given for circumcision, but his ‘circumcision’ of the word
circumcision
. I propose the viewing of deconstruction as the spiritual and ethical equivalent of circumcision.
Ödeme Gücüne Ulaşarak Adil Vergi Sistemi Oluşturma: Seçilmiş AB Ülkeleri İncelemesi
Authors: Aydın Mehmet Sadık
Published: April 2022

Kamu hizmetlerinin sunumunun en önemli finansman kaynağı vergilerdir. Vergi hasılatını sağlamanın en iyi yolu da vergiye karşı direnci minimum seviyede tutmaktır. Vergiye karşı direnci minimum seviyede tutmanın en iyi yolu da adil bir vergi sistemini inşa etmektir. Adil bir vergi sistemi aracılığıyla mükelleflerin vergi uyumunun artırılması beklenmektedir. Vergi sistemi oluşturulurken iki yaklaşıma göre vergilendirme yapılmaktadır. Fayda yaklaşımı ve ödeme gücü yaklaşımıdır. Ödeme gücünün en önemli göstergesi gelirdir. Diğer ödeme güçleri de gelir üzerinden ifade edilmektedir. Gelirin tüketime ayrılan kısmına harcama denilirken, tasarrufa ayrılan kısmına da servet denilmektedir. Dolayısıyla ödeme gücünün göstergeleri; gelir, servet ve harcamadan oluşmaktadır. Ödeme gücüne ulaşmada da çeşitli yöntemler kullanılmaktadır. Artan oranlı vergileme, ayırma prensibi ve en az geçim indirimi ödeme gücüne ulaşmada kullanılan yöntemlerdir. Bu çalışmada ödeme gücüne ulaşmada kullanılan yöntemlerin seçilmiş AB ülkelerinde nasıl uygulandığı, bunun vergi hasılatına etkisi ve adil vergileme ile ilişkisi üzerinde durulacaktır. Çalışma kapsamında sistemlerin adil olup olmaması tartışmasından ziyade ödeme gücüne ulaşmada kullanılan yöntemlere ilişkin veriler kullanılarak ödeme gücünün vergi adaleti ile ilişkisi ortaya konulacaktır. Çalışmada AB üye ülkelerin verilerinden yararlanılarak literatür taraması ile verilerin analizi yöntemi uygulanmıştır. Çalışma aracılığıyla; ödeme gücüne ulaşmada uygulanan yöntemler kullanılarak vergide adalet ve adalet algısı ilişkisini ortaya koyup literatüre katkı sunulması amaçlanmaktadır. Çalışma sonucunda AB üye ülkelerinde vergi sistemlerinin farklı olduğu, ödeme gücüne ulaşmada kullanılan yöntemleri farklı şekilde uyguladıkları ve bunun da genelleme yapılması önünde engel oluşturduğu bulgusuna ulaşılmıştır.
Anahtar Kelimeler: Ödeme Gücü, Artan Oranlılık, Ayrıma Prensibi
JEL Sınıflandırması: H2, H21, H10
Dış Ticaret ve Göç İlişkisi: İtalya ve İspanya Örneği
Authors: Şahin Suna
Published: April 2022

Göçün kaçınılmaz ve çok boyutlu olduğu son derece hareketli bir dünyada yaşıyoruz. Uluslararası göçün süreçlerini anlamak için geliştirilen teoriler ve her perspektifin varsayımları ile hipotezleri doğası gereği çelişkili olmasa da, politikaların uygulanması açısından çok farklı çıkarımları taşımaktadırlar. Ülkeler farklıdır ve bir ülke için en uygun olan şey başka bir ülke için geçerli olmayabilir.İtalya ve İspanya’da dış ticaret ve göç ilişkisinin incelenmesini amaçlayan bu çalışma, 1990-2018 dönemleri arasını kapsamaktadır. Çalışmaya ait veriler Avrupa İstatistik Ofisi (Eurostat) ve Dünya Bankası (World Bank) veri tabanlarından yararlanılarak derlenmiştir. Çalışma sonuçlarına göre İtalya’ da ithalat ve ihracat göçün Granger nedenidir. İspanya’da ise göç hem ihracatın hem de ithalatın Granger nedenidir. İspanya için göç olgusuna ilave olarak ihracatta ithalatın Granger nedeni olarak bulunmuştur. Çalışma kapsamında bulunan sonuçların uzun dönemli olarak geçerliliği Engle-Granger Eşbütünleşme analizi yardımı ile sınanmış ve uzun dönemli ilişki kabul edilmiştir.Anahtar Kelimeler: Uluslararası Göç, Uluslararası Ticaret, Neo-Klasik Ekonomi, İthalat, İhracatJEL Sınıflandırması: F22, F11, F6.
The Greek Merchants of Moschopolis
Authors: Karakosta Konstantina D.
Published: April 2022

Moschopolitans, the residents of Moschopolis, enjoyed remarkable economic growth and prosperity. The first written records, referring to this shift and proving the commercial presence of Moschopolitans in Venice, have already appeared in the 16th century and consist mainly of correspondence. Exports of processed and unprocessed wool and the development of commercial contacts with markets of Venice constitute proof of the developed livestock in the studied area, which soon led to surplus products and the need for migration in search of new markets. So, a mountainous enclave was formed. The fabric was produced and exported to foreign markets and contributed to the initial formation of the “Industrial Revolution” in the Turkish-occupied country. Gradually, small domestic industries became the most important economic factor of the mountainous area throughout the 18th and 19th centuries. The article studies the trade relations of Moschopolitans with the ports of Venice, Dyrrachium (Durrës) and Ragusa (Dubrovnik), through the commercial correspondence, the role of the Venetian consul (bailo) in Dyrrachium, Moschopolitans relations with the authorities of Constantinople and Dyrrachium and how and why they gradually withdrew from the markets of Venice.
Harassment of Women in University and Public Transport
Authors: Sumbal Sumbal
Published: April 2022

The present study was conducted to find out the existing problems of university and public transport from the perspective of females in Abdul Wali Khan University Mardan, KP, Pakistan. The study examines the issue of harassment in university and public transport the female faces every day. The study uses the quantitative method and random sampling, which belongs to probability sampling—the data collected from the study area through the questionnaire. The study shows that students and employees were 18 to 31 years old in which majority of the female's faces problems in public transport and few were faced problems in university transport. The study shows that the female passenger was unwilling to use public transport. They found it the most unattractive mode of transportation. Moreover, the study shows that most females reported facing the misbehaviour of drivers and co-passengers. The female passengers do not want to use public transport to avoid unpleasant situations. They also feel unsafe from drivers because they make rude remarks behind them, harass them, and miss their behaviour. Most of them want to act against the harassers, but they are afraid, and those who are harassed do not complain to the higher authorities because they think it can affect their selfrespect and reputation. Further studies need to be conducted to get more information about public and university transport harassment.
Les Facteurs Individuels Et Contextuels De Risque De L’anemie Chez Les Enfants De 6-59 Mois Au Burkina Faso
Authors: Karim Yelbi , Kouam Nadège Chouapi , Bougma Moussa
Published: April 2022

Bien que l’anémie soit reconnue depuis de nombreuses années comme un problème de santé publique majeur au Burkina Faso, peu de progrès ont été réalisés dans sa lutte et son niveau élevé de prévalence à l’échelle nationale (88%) reste préoccupant. Cet article vise à contribuer à l’amélioration des connaissances sur les facteurs individuels et contextuels de risque de l’anémie chez les enfants en utilisant les données de la quatrième Enquête démographique et de santé, et à indicateurs multiples du Burkina Faso (EDSBF-MICS IV) réalisée en 2010. Les méthodes d’analyse utilisées sont descriptives et explicatives. Les résultats obtenus montrent l’effet significatif des variables individuelles (âge de l’enfant, état anémique de la mère, état nutritionnel de l’enfant …) et contextuelles (zone agroécologique de résidence, proportion d’enfants impaludés dans la communauté, milieu de résidence) sur l’état d’anémie des enfants. Globalement, cette étude suggère la prise en compte des dimensions individuelles et communautaires dans l’élaboration des politiques et programmes de lutte contre l’anémie et une sensibilisation conséquente des populations à de meilleures pratiques nutritionnelles.

Although anemia has been recognized for many years as a major public health issue in Burkina Faso, little progress has been made in terms of its eradication, and its high prevalence level (88%) throughout the country remains a concern. This article aims to improve our knowledge of the individual and contextual risk factors for anemia in children using data from the last Demographic and Health Survey, and Multiple Indicators (DHS-MICS IV) carried out in 2010. Based on descriptive and explanatory methods, the results of the study show a significant effect of individual variables (age of the child, anemic state of the mother, nutritional state of the child, etc.) and contextual variables (agro-ecological zone of residence, proportion of malaria-infected children in the community, environment of residence) on the anemia status of children. Overall, this study suggests an inclusion of individuals and communities in the development of policies and programs to eradicate anemia as well as a substantial sensitization of populations for better nutritional practices.
Influence of Certain Nutritional Products On Periodontal Status
Authors: Urim Tefiku , Mirjana Popovska , Amella Cana , Zendeli Bedxeti Lindita , Bilbil Recica , Spasovska-Gjorgovska Ana , Spasovski Spiro
Published: April 2022

Material and Method: 60 patients within the age range of 35-65 years were included. The selection of the respondents was made by a simple random method.  As a criterion in the research sample, the depth of the periodontal pockets was taken into account, which was from 3 to 5 mm, according to which a selection was made.  Chronic periodontal disease with a clinically manifest stage was diagnosed in all patients. Each of the respondents had the opportunity to estimate the frequency of personal consumption of 6 selected food items (vegetables, fast food, fish, meat, fruits, and desserts) by choosing one of three possible answers (never, infrequently and often consumed). For the clinical part of the study, 4 parameters were measured, namely: GI-gingival inflammation, PI-plaque index, PPD-depth of periodontal pockets, and CAL-clinical loss of attachment. The findings were statistically processed.

Results: For the male and female respondents, the average age was 39.8 ± 5.3 with min/pop of 30/53 years and 41.2 ± 6.3 with min / pop of 32/55 years, respectively.

The analysis showed that, for p> 0.05, the frequency of consumption of vegetables significantly decreased, and the consumption of fast food insignificantly increased the values of the four clinical parameters (GI, PI, PPD, CAL).

Conclusion: Consumption of fish, meat, and vegetables reduces the values of clinical parameters (PI, GI, PPD, CAL). This is in contrast to fast food and dessert which indicated an increase in the values of PPD and CAL.
Escuela de danza Callao
Authors:   , Salazar Ferreyros Mónica María
Published: April 2022

La escuela de danza busca ser el espacio seguro para jóvenes de entornos conflictivos y otros jóvenes del Callao que deseen desarrollarse en este arte, donde puedan expresarse y desarrollarse artísticamente teniendo como consecuencia una mejoría en su vida emocional. El usuario principal es el joven de entre 15 y 25 años que busquen desarrollarse en el mundo del arte de la danza, además de aquellos de escasos recursos que están en riesgo de caer en delincuencia. El lugar donde se emplaza el proyecto es en la Provincia Constitucional del Callao, frente a la Fortaleza Real Felipe. Localiza entre dos de las zonas con más conflictivas del Callao, facilita el acceso a los alumnos. El principal concepto que se utiliza para el desarrollo del proyecto es el de la arquitectura como bisagra o nexo entre el pasado, el presente y el futuro del lugar, pero enfocado a una arquitectura actual, que brinde espacios ricos formados con materiales contemporáneos y colores que acentúen elementos específicos. Busca ser un edificio ito que pase a formar parte de la identidad del lugar, del cual los chalacos estén orgulloso. Este respeta su entorno, busca generar espacios privado-públicos y separa los paquetes funcionales del auditorio, escuela y servicios generales para que tengan accesos independientes y puedan funcionar por separado. A continuación, se presenta la investigación previa al diseño del proyecto.
Análisis experimental de intersecciones amplias tipo cruz en base a la metodología de flujo continuo. Caso avenida República de Venezuela con la avenida Aurelio García y García
Authors:   , Chuco Pozo Betsi Suliana , Perez Ramos Carlos Edgar
Published: April 2022

Las ciudades altamente congestionadas requieren de una óptima gestión de la movilidad urbana. Muchas de estas ciudades se caracterizan porque su infraestructura vial no va acorde con su demanda vehicular, como es el caso de la ciudad de Lima. Por consiguiente, se debe priorizar el desarrollo de la infraestructura vial, ya que existen por ejemplo intersecciones amplias que presentan gran cantidad de puntos de conflicto. En efecto, reducen la capacidad operacional y el nivel de servicio de la intersección. Esta investigación tiene como objetivo reducir los puntos de conflicto y el tiempo de cruce en intersecciones amplias tipo cruz, en base a la Metodología de Flujo Continuo (CFI, por sus siglas en inglés) con delineadores elevados (bolardos compuestos) y detectores (sensores) a fin de mejorar la capacidad y seguridad operacional de la intersección. El objeto de estudio de la presente investigación se encuentra en una zona comercial ubicada entre la Avenida República de Venezuela con la Avenida Aurelio García y García, Lima. Los movimientos vehiculares de giro a la izquierda son los que afectan el rendimiento de las intersecciones señalizadas. Por tanto, se recolectaron 3219 vehículos en total, de los cuales 561 vehículos giraron a la izquierda demostrando así la alta densidad de este tipo de maniobras. La efectividad del diseño propuesto se valida empleando una microsimulación en el software Vissim. Los resultados obtenidos muestran los puntos de conflictos tipo cruz se redujeron a 8 puntos con el modelo propuesto frente al estado actual, el cual posee 58 puntos de conflictos tipo cruz. Por otro lado, el tiempo promedio de cruce de los vehículos disminuyó en 4.20 y 9.79 segundos en la fase 1, debido al rediseño de la geometría de la intersección. En efecto, la capacidad operacional aumentó en 33.85%, ya que el aforo vehicular con el nuevo ciclo semafórico de 150 segundos es de 431vehículos con respecto a los 322 vehículos que se tenía con el modelo anterior. Finalmente, los riesgos de colisiones posteriores y laterales se reducen mediante el uso de delineadores elevados en un 83%.
The Effects of Social Assistance Interventions on Gender, Familial and Household Relations Among Refugees and Displaced Populations: A Review of the Literature on Interventions in Syria, Iraq, Jordan and Lebanon
Authors: Oosterhoff Pauline , Yunus Raudah M.
Published: April 2022

This literature review aims to explore the evidence on the effects of social assistance on gender, familial, and household relations and power dynamics among refugees and (internally) displaced populations in Syria, Iraq, Jordan, and Lebanon. It examines the findings from an intersectional gender perspective allowing the authors to build on the knowledge of ‘what works’ in interventions in general and hopefully improve gender equality and social inclusion. Out of 1,564 papers initially identified and screened, 22 were included in the final stage. A question that emerged as the papers were analysed was whether the arduous work of targeting individuals was efficient or necessary, given that the available evidence suggests that beneficiaries generally tend to share their stipend with other family members for the collective good. Most studies tended to conflate gender with women and girls – making distinctions between widowed, married, unmarried and divorced women – but ignoring other dimensions such as class, health status, religion, ethnicity, education, prior work experience, political affiliation, and civil participation. Many programmes and research fail to disaggregate data. Social assistance programmes focus on individuals and households, with little attention to the wider context and overall conflict. Most studies paid negligible attention to familial infrastructures and strategies for sustainable interventions. Access to, and use of, cash transfers are part of broader familial strategies to mobilise or increase resources including, for example, (male) migration in pursuit of remittances, or (female) dependency on ‘community charity’. Short-term cash transfers can, in some circumstances, disrupt individuals’ and families’ access to more sustainable income or ‘charity’. Thus, important questions are raised about the purpose of social assistance: does it aim to preserve or transform families through targeting?
Donor Action for Empowerment and Accountability in Nigeria
Authors: Aremu Fatai
Published: April 2022

Multiple development actors are interested in stimulating more inclusive fiscal governance. Efforts to generate greater budget transparency, citizen participation in resource allocation, and public oversight of government spending are commonplace. How can development donors and lenders support such efforts, and what are their limitations? How do their attempts to do so interact? Exploring the outcomes of two projects in the Nigerian States of Jigawa and Kaduna provide some answers to these questions. The projects pursue overlapping goals, but with different approaches. The Partnership to Engage, Reform and Learn (PERL) programme funded by the UK Foreign, Commonwealth & Development Office works in a granular and contextually adapted way in each state to construct joint government and civil initiatives that test and embed citizen engagement and oversight approaches. The World Bank States Financial Transparency Accountability and Sustainability (SFTAS) initiative offers financial incentives to states if they meet a set of common public financial management benchmarks. Their actions have been complementary in several ways, despite significant contextual differences between the states in terms of conflict dynamics and prevailing citizen–state relations. The projects also reinforced each other’s efforts on public procurement reform in Kaduna State. However, in Jigawa State, SFTAS incentives to pass a procurement law following a standard template failed to codify and may indeed reverse gains from longstanding PERL efforts supporting transparency. This illustrates how donors with similar reform objectives in the same contexts can unconsciously undermine existing efforts towards overarching public accountability goals.
ISLAMIC GATHERING AS A MEDIA INCREASING THE SPIRITUAL INTELLIGENCE OF STUDENTS AT INFORMATICS VOCATIONAL SCHOOL IN THE ERA OF COVID-19
Authors: Murniasih Eri , Wasehudin Wasehudin
Published: April 2022

The purpose of this study is to see how the implementation of the Islamic Gathering program at the Informatics Vocational School in Serang City during the Covid-19 pandemic influenced students' spiritual intelligence. The descriptive qualitative method was used in this study. The data were gathered through interviews and observations. Oral interviews were performed with the principal, three teachers participating in the implementation of Islamic gathering events, specifically teachers of Islamic Religious Education subject, and 12 students from classes XI and XII. Observations were also conducted on the activities and students at the Islamic Gathering. The study's findings revealed that the Islamic Gathering program is an activity that combines religious studies with religious routines from noon to noon, and that during the COVID-19 pandemic, this activity was carried out both online and offline, with the goal of increasing students' spiritual intelligence as evidenced by changes in their attitudes, such as the ability to live more valuable lives, and changing students' perspectives toward religion.
Pelibatan Orang Tua dalam Mendukung Program Sekolah se-Gugus Teratai Kecamatan Pondok Suguh Kabupaten Mukomuko
Authors: Yuvita Insyirah , Kurniah, M.Pd Drs.Nina , M.Sn Wembrayarli,
Published: April 2022

Tujuan penelitian ini untuk mendeskripsikan bentuk pelibatan orang tua dalam program parenting dan communicating di PAUD se-Gugus Teratai Desa Pondok Suguh Kecamatan Pondok Suguh Kabupaten Mukomuko. Metode yang digunakan dalam penelitian ini adalah deskriptif kuantitatif, sedangkan teknik pengumpulan data menggunakan angket. Populasi dalam penelitian ini yaitu 16 orang guru, sedangkan teknik pengambilan sampel yaitu total sampling. Data yang terkumpul dianalisis dengan menggunakan analisis statistik dengan rumus persentase. Hasil penelitian ini dapat disimpulkan bahwa kegiatan pelibatan orang tua dalam mendukung program sekolah yang telah dilaksanakan oleh semua PAUD se-Gugus Teratai Kecamatan Pondok Suguh Kabupaten Mukomuko dalam program parenting meliputi kegiatan pertemuan orang tua dan pelibatan orang tua dalam acara bersama, sedangkan dalam program communicating meliputi bentuk komunikasi tidak langsung menggunakan media elektronik. Saran penelitian ini yaitu pada pihak sekolah untuk bisa meningkatkan pelaksanaan dalam setiap kegiatan dan melakukan upaya untuk mengatasi penyebab kurangnya pelaksanaan dalam kegiatan tersebut.
Angioedema: Abordagem Diagnóstica e Terapêutica em Contexto de Urgência
Authors: Alen Coutinho Iolanda , Luís Marques Maria , Carneiro-Leão Leonor , Santos Natacha , Castro Neves Ana , Gaspar Ângela , Spínola Santos Amélia , Branco Ferreira Manuel
Published: April 2022

N/a.
Caring for People with Autism Spectrum Disorder and Cancer
Authors: Freitas Ramos Sara , Moura Bárbara , Corvacho Mafalda , Tavares Assunção
Published: April 2022

N/a.
Revolução e transição política
Authors: Finatti Renata Riva
Published: April 2022

O presente trabalho, de cunho qualitativo e documental, objetiva analisar o desenho de democratização da gestão da educação em articulação com a forma pela qual os países saem de um regime autoritário e constituem-se Estados Democráticos. As análises deram-se a partir da legislação promulgada nos primeiros anos após uma transição política (Brasil, década de 1980) e uma revolução (Portugal, 1974), bem como dos estudos sobre a temática publicadas em cada um dos contextos. Descrevem-se, portanto, duas experiências que, apesar das semelhanças nas normativas, são distintas especialmente quanto às vivências e à construção de processos democratizantes para a gestão de seus sistemas educacionais. Estas vivências, no âmbito da escola, caracterizaram fortemente a constituição legal em Portugal, enquanto no Brasil as normativas foram construídas sem esta vinculação à realidade escolar, mas com pautas ainda discursivas de diversos movimentos.
A importância do centro de simulação na Educação Médica
Authors: Giugni Fernando Rabioglio , Scalabrini Neto Augusto
Published: April 2022

O centro de simulação é um local que reúne infraestrutura e recursos humanos adequados para o ensino baseado em simulação. Surgiu no final do século XX, em decorrência do desenvolvimento tecnológico dos simuladores e da progressão da metodologia de ensino, com necessidade de ambiente de maior realismo.

Nas últimas décadas, as metodologias ativas de ensino ganharam espaço e vêm sendo incorporadas na educação médica. A simulação permite que o aluno desenvolva as competências necessárias em um ambiente seguro e controlado. O centro de simulação é fundamental para uma adequada implementação do ensino baseado em simulação no currículo médico.

Os modernos centros de simulação possuem infraestrutura que conta com salas para treinamento de habilidades, salas para simulação clínica com simuladores de alta fidelidade e local adequado para debriefing. Também devem contar com profissionais técnicos em simulação e docentes capacitados. Dentre os principais desafios para o futuro dos centros de simulação, destacam-se a incorporação de novas tecnologias, o treinamento do corpo docente e a integração multiprofissional.
Simulação no ensino de estudantes e aperfeiçoamento de profissionais da saúde
Authors: Beltrão Beatriz Amorim , Montenegro Júnior Renan Magalhães
Published: April 2022

A simulação realística figura entre as mais modernas e eficientes metodologias ativas de aprendizado de profissionais da saúde. Na UFC, a simulação já integra, há alguns anos, como estratégia utilizada para a formação de estudantes dos cursos de Medicina e Enfermagem. Ambos os cursos dispõem de laboratórios e acervos próprios, voltados para o desenvolvimento de competências e habilidades inerentes à suas respectivas grades curriculares, possibilitando o ensino em ambientes seguros e controlados.
Chronic activation of MUC1-C in wound repair promotes progression to cancer stem cells
Authors: Kufe Donald W.
Published: April 2022

The mucin 1 (MUC1) gene emerged in mammals to afford protection of barrier epithelial tissues from the external environment. MUC1 encodes a transmembrane C-terminal (MUC1-C) subunit that is activated by loss of homeostasis and induces inflammatory, proliferative, and remodeling pathways associated with wound repair. As a consequence, chronic activation of MUC1-C promotes lineage plasticity, epigenetic reprogramming, and carcinogenesis. In driving cancer progression, MUC1-C is imported into the nucleus, where it induces NF-κB inflammatory signaling and the epithelial-mesenchymal transition (EMT). MUC1-C represses gene expression by activating (i) DNA methyltransferase 1 (DNMT1) and DNMT3b, (ii) Polycomb Repressive Complex 1 (PRC1) and PRC2, and (iii) the nucleosome remodeling and deacetylase (NuRD) nucleosome complex. PRC1/2-mediated gene repression is counteracted by the SWI/SNF chromatin remodeling complexes. MUC1-C activates the SWI/SNF BAF and PBAF complexes in cancer stem cell (CSC) models with the induction of genome-wide differentially accessible regions and expressed genes. MUC1-C regulates chromatin accessibility of enhancer-like signatures in association with the induction of the Yamanaka pluripotency factors and recruitment of JUN and BAF, which promote increases in histone activation marks and opening of chromatin. These and other findings described in this review have uncovered a pivotal role for MUC1-C in integrating lineage plasticity and epigenetic reprogramming, which are transient in wound repair and sustained in promoting CSC progression.
The use and applicability of Internet search queries for infectious disease surveillance in low- to middle-income countries
Authors: Beckhaus Julia , Becher Heiko , Belau Matthias Hans
Published: April 2022

Uncontrolled outbreaks of emerging infectious diseases can pose threats to livelihoods and can undo years of progress made in developing regions, such as Sub-Saharan Africa. Therefore, the surveillance and early outbreak detection of infectious diseases, e.g., Dengue fever, is crucial. As a low-cost and timely source, Internet search queries data [e.g., Google Trends data (GTD)] are used and applied in epidemiological surveillance. This review aims to identify and evaluate relevant studies that used GTD in prediction models for epidemiological surveillance purposes regarding emerging infectious diseases. A comprehensive literature search in PubMed/MEDLINE was carried out, using relevant keywords identified from up-to-date literature and restricted to low- to middle-income countries. Eight studies were identified and included in the current review. Three focused on Dengue fever, three analyzed Zika virus infections, and two were about COVID-19. All studies investigated the correlation between GTD and the cases of the respective infectious disease; five studies used additional (time series) regression analyses to investigate the temporal relation. Overall, the reported positive correlations were high for Zika virus (0.75-0.99) or Dengue fever (0.87-0.94) with GTD, but not for COVID-19 (-0.81 to 0.003). Although the use of GTD appeared effective for infectious disease surveillance in low- to middle-income countries, further research is needed. The low costs and availability remain promising for future surveillance systems in low- to middle-income countries, but there is an urgent need for a standard methodological framework for the use and application of GTD.
Design and Application of Nursing Record Sheet and Operation Registration Form for Ophthalmic Daytime Operation
Authors: Hong Jie
Published: April 2022

Objective: To explore the effect of nursing record sheet and operation registration form in daytime ophthalmic surgery. Methods: the nursing record sheet and operation registration form of daytime ophthalmic surgery were designed and used to evaluate the incidence of adverse events and the satisfaction of doctors in the operating room before and after use. Results: from January 2018 to June 2019, there were 15 adverse events caused by unclear handover, wrong record, wrong eye classification, wrong application of antibiotics and waiting for surgical consumables in ophthalmology due to nursing record, with an incidence of 3.71%;From July 2019 to December 2020, there were only 2 cases of ophthalmic defects caused by the record sheet, with an incidence of 0.42%;The difference was statistically significant(P=0.00095). When the daytime ophthalmic surgery nursing record sheet was not used from January 2018 to June 2019, the satisfaction of ophthalmic surgeons was 71%, and after using the daytime ophthalmic surgery nursing record sheet from July 2019 to December 2020, the satisfaction of ophthalmic surgeons increased to 96%. Conclusion the design of daytime ophthalmic surgery nursing record sheet is reasonable and convenient, which can effectively ensure the quality of daytime ophthalmic surgery nursing, improve work efficiency and improve job satisfaction of surgeons.
Analisis Kebijakan Indonesia Bekerja Sama dengan Jepang dalam Proyek Kereta Cepat Jakarta-Surabaya
Authors: Prasodjo Haryo , Khairur Rijal Najamuddin
Published: April 2022

In 2015, Japan had to step down when Indonesia chose China in the 142.3 km Jakarta-Bandung fast train project. In 2016, the Government of Indonesia held a meeting with the Government of Japan, to discuss a project to continue the fast train, with the Jakarta-Surabaya route. Interestingly, the Jakarta-Surabaya fast train project was carried out directly without going through a tender process like the Jakarta-Bandung fast train project. Using an empirical rationality theory approach, this paper seeks to look at several factors behind the Indonesian government's policy of choosing Japan in the Jakarta-Surabaya semi-fast train project. Several aspects that will be examined in this research are, first, conditions and situations in Indonesia that require decision making. Second, Japan's commitment to Indonesia and the capacity and capability of Japan's fast train technology. Third, the various benefits obtained by Indonesia from the cooperation of the semi-fast train with Japan.