bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Kondisi Kelayakan Wisata Oray Tapa berdasarkan Komponen Pariwisata
Authors: Amanda Fisela , Akliyah Lely Syiddatul
Published: September 2022

Abstract. Mekarmanik Village has the potential to be developed into a tourist area, namely in Oray Tapa which presents all natural However, currently there are several problems related to the existing condition of the 4 components that must be owned by a tourist area and it can be said that it is feasible if 4A (attraction, accessibility, amenities, additions) tourism components have been fulfilled which will affect its development. Therefore, it is necessary to identify the feasibility conditions of the 4 tourism components contained in Oray Tapa so that their development can run optimally. The purpose of this study was to identify the feasibility conditions of the 4 tourism components contained in Oray Tapa. This study uses a qualitative descriptive analysis method, while the assessment is based on the Guidelines for Analysis of Areas of Objects and Natural Tourism Attractions by the Director General of PHKA in 2003. Based on the analysis results show that the 4 components of tourism in Oray Tapa are included in the unfeasible category. This means that it is necessary to make improvements to each component so that its development runs optimally.

Abstrak. Desa Mekarmanik memiliki potensi yang dapat dikembangkan menjadi kawasan wisata yaitu terdapat di Oray Tapa yang menyuguhkan segala sumber daya alam. Namun saat ini terdapat beberapa permasalahan yang berkaitan dengan kondisi eksisting 4 komponen yang wajib dimiliki oleh suatu daerah wisata dan dapat dikatakkan layak apabila komponen 4A (attraction, accessibility, amenity, ancilliary) pariwisatanya sudah terpenuhi yang mana akan berpengaruh terhadap pengembangannya. Maka dari itu dibutuhkan identifikasi terhadap kondisi kelayakan 4 komponen pariwisata yang terdapat di Oray Tapa agar pengembangannya dapat berjalan secara optimal. Tujuan dari penelitian ini adalah untuk mengidentifikasi kondisi kelayakan 4 komponen pariwisata yang terdapat di Oray Tapa. Penelitian ini menggunakan metode analisis deskriptif kualitatif, adapun penentuan penilaian mengacu kepada Pedoman Analisis Daerah Operasi Objek dan Daya Tarik Wisata Alam (ADO-DTWA) Dirjen PHKA Tahun 2003. Berdasarkan hasil analisis yang dilakukan, menunjukkan bahwa 4 komponen pariwisata di Oray Tapa termasuk dalam kategori belum layak. Artinya, perlu adanya pembenahan dalam setiap komponen agar pengembangannya berjalan secara optimal.
Kepuasan Pengendara Motor Terhadap Penggunaan Smart system parking di Ruas Jalan Braga, Kota Bandung
Authors: Dhea Viranti Alaydrus  , Ina Helena Agustina
Published: September 2022

Abstract. The smart system parking machine is not functioning properly, so it is necessary to evaluate whether the machine is useful or not for the parking system on Braga road. To determine the effectiveness of using smart system parkings on Braga road researcher uses descriptive research method with a qualitative approach. In this study, researchers used Likert scale analysis with research variables and indicators, namely motorcycle rider satisfaction and management of the use of smart system parkings on  Bandung City ,Braga road. The analysis is used to determine the satisfaction of motorcyclists with the smart system parking on Braga road. The result of this study are level of motorist satisfaction is seen from the location placement, the tariff issued, the level of service and the carrying capacity. The use of this smart system parking is managed by a parking institution that is under the auspices of the Department of Transportation where the collection is directly by the Department of Transportation through a parking interpreter who manages the smart system parking on Braga road. and security of parking locations.

Abstrak. Mesin smart system parking  tidak berfungsi sebagaimana mestinya maka perlu adanya evaluasi terhadap mesin tersebut apakah bermanfaat atau tidak bagi sistem parkir yang ada di Jalan Braga. Untuk mengetahui keefektifan penggunaan smart system parking  di Jl. Braga ini peneliti menggunakan metode penelitian deskriptif dengan pendekatan kualitatif. Dalam penelitian ini peneliti menggunakan analisis skala likert dengan variabel dan indikator penelitian yaitu kepuasan pengendara motor dan kepengelolaan penggunaan smart system parking  di Jl. Braga Kota Bandung. Analisis digunakan untuk mengetahui kepuasan pengendara motor terhadap smart system parking  di Jl.Braga. Hasil penelitian ini yaitu tingkat kepuasan pengendara dilihat dari penempatan lokasi, tarif yang dikeluarkan tingkat pelayanan dan daya dukung. Penggunaan smart system parking  ini dikelola oleh suatu kelembagaan parkir yaitu dibawah naungan Dinas Perhubungan yang dimana, pemungutan nya langsung oleh pihak Dinas Perhubungan melalui juru parkir yang mengelola smart system parking  di Jalan Braga. Butuh pengembangan, yaitu para masyarakat khususnya pengendara motor adalah tata cara penggunaan nya dan keamanan lokasi.
Analisis Kerentanan Bencana Tsunami di Wilayah Pesisir Kecamatan Labuan
Authors: Eka Chandra Ramadhan  , Chamid Chussarini
Published: September 2022

Abstract. The examination region is geologically situated on the west bank of Pandeglang Rule, which as far as area has shown that it is inclined to wave catastrophes, additionally the exploration area is straightforwardly neighboring the Sunda Waterway and near Mount Krakatau. The motivation behind this review is to decide the degree of actual weakness, social weakness, monetary weakness, ecological weakness and the wave weakness file. Notwithstanding weakness, This exploration strategy utilizes unmistakable quantitative and subjective techniques to clarify the connection between weakness investigation boundaries and the public authority's job in catastrophe alleviation in the beach front space of Labuan Locale. The consequences of this review, it is realized that the degree of weakness in the seaside space of Labuan Region has a high arrangement esteem, and furthermore dependent on the aftereffects of examination on the job of the nearby government in completing torrent debacle relief endeavors in the beach front space of Labuan Region is likewise still not ideal.

Abstrak. Wilayah penelitian secara geografis terletak di pantai barat Kabupaten Pandeglang, yang dimana lokasi tersebut memiliki kecenderungan rawan bencana, karena wilayah penelitian berbatasan langsung dengan Selat Sunda dan Gunung Krakatau. Tujuan dari penelitian ini untuk menentukan tingkat kerentanan fisik, kerentanan sosial, kerentanan ekonomi, kerentanan lingkungan dan indeks kerentanan tsunami. Selain kerentanan penelitian ini juga bertujuan untuk mengetahui peran pemerintah dalam melakukan mitigasi sehingga dapat mencegah dan mengurangi dampak terjadinya resiko bencana tsunami. Metode penelitian ini menggunakan metode kuantitatif dan kualitatif deskriptif untuk memperjelas hubungan antara parameter analisis kerentanan dengan peran pemerintah dalam melakukan penanggulangan bencana tsunami di wilayah pesisir Kecamatan Labuan. Hasil penelitian ini disadari bahwa tingkat kerentanan pada wilayah pesisir Kecamatan Labuan memiliki nilai klasifikasi tinggi, dan selanjutnya pada hasil penelitian terhadap peran pemerintah setempat dalam melakukan upaya mitigasi bencana tsunami di wilayah pesisir Kecamatan Labuan juga masih belum ideal.
Taksiran Total Fertilitas Rate Penduduk Jabar Periode 2015 - 2020 dan 2020 - 2025
Authors: Rizki Monika , Karyana Yayat
Published: September 2022

Abstract. The population problem in Indonesia is a fairly important problem considering the number of Indonesians who are in fourth place as the country with the largest population. The case study is estimating the TFR figure and the population of West Java Province for the 2015 - 2020 period and a literature study studying the literature on basic theories related to population growth problems related to vital events, namely fertility. The data analysis technique used in this research is the indirect method. Based on the results of SP 2020, the population of West Java aged 0-4 years, there are 2,004,029 men and 1,910,514 women. With the number of births during these 5 years, the calculation results produce an estimated TFR of the population of West Java in the 2015 - 2020 period is TFR = 2.12. Based on the projections for 2025, the population of 0-4 years is 1,957,026 women and 2,045,940 men, with the total number of men and women being 4,002,966. With the number of births during these 5 years, the calculation results produce an estimated TFR of the population of West Java in 2020 - 2025 is TFR = 2.12.

Abstrak. Permasalahan kependudukan di Indonesia menjadi masalah yang cukup penting mengingat jumlah penduduk Indonesia yang berada pada urutan keempat sebagai negara dengan jumlah penduduk terbesar. Studi kasus yaitu memperkirakan angka TFR dan jumlah penduduk Provinsi Jawa Barat periode 2015 - 2020 dan studi literatur mempelajari pustaka tentang teori dasar yang berkaitan dengan permasalahan pertumbuhan penduduk yang berhubungan dengan peristiwa vital yaitu fertilitas. Teknik analisis data yang digunakan dalam penelitian ini adalah metode tidak langsung. Berdasarkan hasil SP 2020 penduduk Jawa Barat berumur 0-4 tahun terdapat 2.004.029 orang laki-laki dan 1.910.514 orang perempuan. Dengan banyaknya kelahiran selama 5 tahun tersebut, hasil perhitungan menghasilkan perkiraan TFR penduduk Jawa Barat pada tahun periode 2015 – 2020 adalah TFR=2,12. Berdasarkan hasil proyeksi tahun 2025 penduduk 0-4 tahun terdapat 1,957,026 orang wanita  dan   2,045,940  orang laki-laki dengan jumlah keseluruhan laki-laki dan perempuan adalah   4,002,966  orang. Dengan banyaknya kelahiran selama 5 tahun tersebut, hasil perhitungan menghasilkan perkiraan TFR proyeksi penduduk Jawa Barat pada tahun 2020 - 2025 adalah TFR=2,12.
Pemodelan Faktor-Faktor yang Mempengaruhi Harga Rumah di Jabodetabek Menggunakan Metode Regresi Probit
Authors: Febyanti Fifia
Published: September 2022

Abstract. In addition to clothes and food, houses are one of the basic needs. The lifestyle of dynamic modern society tends to require houses with various public and social facilities in one area. Property value will be formed through a factor of the completeness of the characteristics of the house and vehicle or facilities available. The price is a measuring device in the form of money, where the price can be obtained by a number of goods or services through the exchange process and obtain the rights and benefits of these goods or services. In this study want to know what factors affect house prices in Jabodetabek by using ordinal probit regression, where home prices consist of three categories, namely cheap, medium and expensive. The data used secondary data obtained from the site of the roof. MAI, namely the dataset of house prices in Indonesia. Based on the data analysis can be seen that the factors that influence the price of houses in Jabodetabek are the type of house, certificate, number of bedrooms, the number of bathrooms, and floors. The accuracy of the classification of 25.6% percent and the value of pseudo  mcfadden of 57.57 percent.

Abstrak. Selain pakaian dan makanan, rumah merupakan salah satu kebutuhan pokok. Gaya hidup masyarakat modern yang dinamis cenderung membutuhkan rumah dengan berbagai fasilitas umum dan sosial dalam satu kawasan. Nilai properti akan terbentuk melalui faktor dari kelengkapan karakteristik rumah dan sarana atau fasilitas yang tersedia. Harga merupakan alat pengukur dalam bentuk uang, dimana dengan harga tersebut dapat diperoleh sejumlah barang atau jasa melalui proses pertukaran dan mendapatkan hak serta manfaat atas barang atau jasa tersebut. Pada penelitian ini ingin mengetahui faktor apasaja yang mempengaruhi harga rumah di Jabodetabek dengan menggunakan regresi probit ordinal, dimana harga rumah terdiri dari tiga kategori yaitu murah, sedang dan mahal. Data yang digunakan adalah data sekunder yang diperoleh dari situs atapdata.ai yaitu dataset harga rumah di Indonesia. Berdasarkan analisis data dapat diketahui bahwa faktor-faktor yang mempengaruhi harga rumah di Jabodetabek adalah tipe rumah, sertifikat, jumlah kamar tidur, jumlah kamar mandi, dan lantai. Ketepatan klasifikasi sebesar 25,6% persen dan nilai Pseudo  McFadden sebesar 57,57 persen.
Pengujian Akuifer Sumur Produksi untuk Memenuhi Kebutuhan Pabrik Pengolahan Zircon
Authors: Muhammad Abizard Rizki  , Yunus Ashari  , Indra Karna Wijaksana
Published: September 2022

Abstract. PT. X is a company engaged in the processing of zircon mining materials. In the processing process, it uses a water supply that only comes from groundwater. Groundwater sources at PT. X come from three drilled wells and each well is tested to determine the characteristics of the aquifer and the optimum discharge value. The research was conducted using the method pumping test, Pumping The test is divided into three stages, namely step drawdown test, constant rate test and recovery test. In the stages, the drawdown test and constant rate test groundwater level reduction value is obtained with a certain discharge, while the recovery test obtains the groundwater level recovery value. The results of the pumping test get the optimum discharge value from each well which is 10.6 lt/s for SB-01, 6.2 lt/s for SB-02, and 10.6 lt/s for SB-03, pumping with the optimum discharge into the safe category based on the regional regulation on groundwater damage criteria, West Java Provincial Regulation Number 1 of 2017 concerning the criteria for groundwater damage.

Abstrak. PT. X merupakan perusahaan yang bergerak pada bidang pengolahan bahan tambang zircon. dalam proses pengolahannya menggunakan pasokan air yang hanya berasal dari airtanah. Sumber airtanah di PT. X berasal dari tiga sumur bor dan masing-masing sumur tersebut di uji untuk mengetahui bagaimana karakteristik akuifer dan nilai debit optimum. Penelitian dilakukan dengan metode pumping test, Pumping test terbagi menjadi tiga tahap yaitu step drawdown test, constant rate test dan recovery test. Pada tahapan drawdown test dan constant rate test mendapatkan nilai penurunan muka air tanah dengan debit tertentu, sedangkan recovery test mendapatkan nilai pemulihan muka air tanah. Hasil dari pumping test mendapatkan nilai debit optimum dari masingmasing sumur yaitu sebesar 10,6 lt/det untuk SB-01, 6,2 lt/det untuk SB- 02, dan 10,6 lt/det untuk SB-03, pemompaan dengan debit optimum masuk kedalam kategori aman berdasarkan perda kriteria kerusakan muka airtanah Perda Provinsi Jawa Barat nomor 1 tahun 2017 tentang kriteria kerusakan muka airtanah.
A clinical case of linear stromal (interstitial) keratitis
Authors: Direev A. O. , Chernykh V. V.
Published: September 2022

Background. Keratitis, characterized by superficial inflammation, cellular infiltration and vascularization of the stroma with minimal involvement of the corneal epithelium and endothelium, is an extremely rare specific condition, that has been isolated, as a separate nosology – linear interstitial keratitis.

The aim. Clinical case demonstration of linear stromal keratitis, using modern methods of corneal examination and world literature analysis, devoted to this problem, from the point of view of determining disease etiology.

Materials and methods. Case demonstration of linear keratitis in a young patient with a recurrent course of the disease is presented.

Results. Рresented clinical case confirms course features and lesion morphology of linear interstitial keratitis.

Conclusion. Linear interstitial keratitis is a rare clinical phenomenon, and its etiology remains uncertain. Confocal microscopy is a promising method of studying linear interstitial keratitis in view of best resolution. Coherent tomography of anterior segment of the eye, is uninformative and does not reflect true depth of the pathological process. Mirror microscopy of endothelial cells confirms confocal microscopy data of panstromic process. Herpes simplex virus and pale treponema roles in the development of linear interstitial keratitis has not been confirmed by existing standard laboratory methods.
Pathological damage of thyroidopathy and the prevalence of thyroid diseases in children of the Perm region
Authors: Shtina I. E. , Valina S. L. , Ivashova Yu. A. , Ustinova O. Yu. , Eisfeld D. A.
Published: September 2022

Relevance. Thyroid diseases in children and adolescents rank first in the structure of endocrine pathology. An issue related to comparability of data on prevalence obtained with different procedures is vital given the necessity to intensify activities aimed at optimizing prevention of thyroid pathology.

The aim. Comparative analysis of pathological lesions of thyropathies and the prevalence of thyroid gland diseases in children and adolescents living in the territory of the Perm region.

Materials and methods. Prevalence of thyroid diseases was analyzed based on data taken from Statistic Form No. 12. Pathological damage caused by thyroid diseases was calculated based on results produced by medical examinations that included laboratory tests, ultrasound scanning of the thyroid gland, and a check-up by an endocrinologist. Calculation results were then compared with data taken from statistic reports. Influence exerted by sex and age on the growth in thyrotrophic hormone contents and thyroid gland volume was assessed by analyzing values in one-factor logistic regression models.

Results. Prevalence of thyroid diseases, endemic goiter and subclinical hypothyroidism tends to decrease among children living in Perm region (р = 0.003–0.015) but prevalence of thyroiditis remains stable (р = 0.794). Having assessed prevalence among teenagers, we did not reveal any dynamics in prevalence of thyroid diseases and thyroiditis (р = 0.129–0.248); prevalence of endemic goiter went down in this age group (р = 0.008) whereas prevalence of subclinical hypothyroidism grew due to iodine deficiency (р = 0.012). The difference between pathological damage and prevalence of thyroid diseases reached 4.8–38.6 times. Having analyzed created logistic models, we were not able to identify sex or age as predictors of thyroid pathology occurrence.

Conclusion. Prevalence of thyroid pathology was established to be by 4.8–38.6 times lower than pathological damage. Iodine deficiency on a given territory calls for developing regional medical and prevention programs aimed at diagnosing and preventing thyroid diseases caused by it.
Letter to the editor. Discussion of the article by A.A. Zarubin, E.S. Filippov, A.S. Vanyarkina, O.G. Ivanova, A.A. Shishkina “Comparison of Uncontrolled and Device-Induced Therapeutic Hypothermia in Newborn Infants with Hypoxic Ischemic Encephalopathy”, published in Acta biomedica scientifica. 2021; 6(1): 88-93. doi: 10.29413/ABS.2021-6.1.13
Authors: Shcherbak V. A. , Kocherova V. V.
Published: September 2022

The article presents a discussion of the study results of the effectiveness of treatment of newborns infants with hypoxic ischemic encephalopathy using device-induced therapeutic hypothermia which were obtained by a group of researchers (Zarubin A.A. et al.) in comparison with the results of Russian and foreign researchers.
Features of the organization of coloproctological care to the population taking into account regional indicators of incidence
Authors: Lisichkin A. L. , Sandakov Ya. P.
Published: September 2022

Rationale. The article provides an analysis of the features of the organization of coloproctological care for the population of the Perm Territory, taking into account regional morbidity rates, which made it possible to identify a number of significant shortcomings. There is no connection between the volume of specialized coloproctological care provided and the real need of the population. It was revealed that 32.0 % of coloproctological patients are being treated by doctors of other specialties. In 2018, 47,172 cases of coloproctological diseases were registered, and only 30,900 specialized outpatient appointments were made in the region (11.7 appointments per 1,000 population). More than half of them (57.4 %) were held in Perm.

The aim of the study. Determination of the features of the organization of coloproctological care for the population of the Perm Territory, considering the incidence rates.

Materials and methods. An analysis was made of the distribution among the adult population of the Perm Territory of pathologies related to the profile of coloproctology according to official statistical reports and the report of the chief specialist of the region for 2018.

Results. In 2018, 3.9 sigmoidoscopies per 1,000 population were performed and 1.7 fibrocolonoscopies per 1,000 population, which led to an insufficient level of diagnosis of coloproctological pathologies. At the same time, identified for the period 2004–2018, a significant increase in the incidence of colorectal cancer (by 48.1 %), with an average annual growth rate over 15 years of 7.8 %, which is 3 times higher than the national figure, requires a change in approaches to the organization of coloproctological care, incl. for early diagnosis.

Conclusion. Thus, in order to improve the quality of early diagnosis of coloproctological, and especially onco-coloproctological diseases, it is required to optimize the outpatient specialized coloproctological care in the Perm region. It is proposed to reorganize the service with the aim of organizing a primary link on the basis of an outpatient coloproctology center with a daily stay hospital, separate or at the coloproctology department of the City Clinical Hospital.
The functional status of forestry industry workers in the Far North during the shift period
Authors: Korneeva Ya. M. , Simonova N. N. , Korneeva A. V. , Trofimova A. A.
Published: September 2022

All over the world, the timber industry is one of the most physically hazardous industries. Working in such conditions is accompanied by an increase in the risk of unfavorable functional states and a critical decrease in professional reliability. Monitoring the workers’ state during the shift period will allow to determine the adaptation degree of personnel to work, as well as to identify the days of the shift arrival with a high risk of injury caused by the unfavorable state of workers.

The aim.To identify and describe the functional states dynamics of loggers during the entire shift period in the Far North as their adaptation degree to work.

Methods.Objective: collection of saliva for the determination of cortisol, psychophysiological instrumental methods; projective: M. Luscher’s color test; subjective – questionnaire “Well-being. Activity. Mood” by V.А. Doskin et al.; statistical methods: descriptive statistics. The study involved 24 shift workers of a logging enterprise, with whom we conducted daily monitoring of objective, projective and subjective characteristics of their functional state in the morning and evening during a fourteenday shift visit.

Results.According to the objective, projective and subjective indicators of functional states, their consistently favorable level is observed with multidirectional peaks during the shift change period and a slight decrease at the end of the shift, which demonstrates the staff’ adaptability to work. The operator performance is somewhat higher in the second half of the shift period, but in general it is below average due to the reduced quality of task performance. An increased free cortisol level was revealed in employees during the entire shift period with a high functional reserves level of the body. During the shift change period, the risks associated with the efficiency and safety of labor increase, which undoubtedly requires consideration by the management of enterprises.
Adults with typical and atypical development: Aspects of self-realization
Authors: Shipova N. S. , Opekina T. P.
Published: September 2022

The desire to realize oneself is characteristic of people, regardless of the state of health.

The scientific problem is based on the need to study the conditions, resources and psychological consequences that ensure self-realization of persons with atypical development in comparison with typically developing people.

The aim of the study. To analyze the specifics of self-realization of people with typical and atypical development, its resources and consequences.

Methods. The sample included 93 people with normative and impaired development (impaired vision, hearing, musculoskeletal system, somatic diseases). Questionnaire methods were used: the test of judgments of self-realization of the personality by S.I. Kudinov; hardiness test of S. Maddi, D.A. Leontiev and E.I. Rasskazova; scale of subjective happiness by S. Lubomirsky and H. Lepper (adapted by D.A. Leontiev and E.N. Osin); scale of subjective well-being A. Perrudet-Badoux (adapted by M.V. Sokolova); self-compassion scale by K. Neff (adapted by K.A. Chistopolskaya et al.); scale of subjective vitality R.M. Ryan and S. Frederick (adapted by L.A. Alexandrova); coping strategies evaluation questionnaire COPE by C. Carver et al. (adapted by T.O. Gordeeva et al.); as well as an author’s interview.

Results. Characteristics of self-realization of persons with typical and atypical development do not have significant differences. Subjects with developmental disorders are more likely to be pessimistic in the context of self-realization. The most successful areas of self-realization for people with atypical development are personal growth and family relationships. In areas related to contacts with the external environment (study, leisure, interpersonal interaction), people with typical development are more realized. The specifics in the aspects of self-realization, components of resilience, subjective well-being, sympathetic attitude towards oneself and preferred coping strategies are revealed.

Conclusion. There is specificity in the aspects of self-realization, its resources and consequences in people with typical and atypical development.
The difficulty of choosing the method of analgesia after total replacement of the lower limb large joints (case report, literature review)
Authors: Lebed M. L. , Kirpichenko M. G. , Vasilyev V. V. , Golub I. E.
Published: September 2022

A case of successful treatment of a patient with a periprosthetic fracture of the femur is described. The fracture occurred one day after total hip replacement as a result of a fall, possibly associated with postoperative conduction analgesia. Lower limb large joints total replacement may become the most frequently performed type of elective surgery already in the current decade. The increasing prevalence of osteoporosis, osteoarthritis, rheumatic diseases and hip fractures is an objective prerequisite for it. Despite of all efforts, the problem of postoperative pain control during these surgical interventions currently remains unresolved. There is currently no “gold standard” for pain relief after total hip and knee replacement surgeries. An excellent ratio of effectiveness and safety is demonstrated by multimodal pain relief programs based on peripheral nerve blocks. However, while having undeniable advantages, conduction anesthesia/analgesia has a critically important drawback. The cornerstone of postoperative rehabilitation for patients undergoing total hip or knee replacement is their early activation. All methods of conduction anesthesia are associated with motor blockade. In particular, femoral nerve block causes weakness of quadriceps muscle of thigh, inducing patients’ inadvertent falling when attempting to stand or walk. The situation with the choice of the method of anesthesia after total replacement of the lower limb large joints can be described as “a long way to go”.
The role of some lipids and their metabolites in programmed cell death (lipoapoptosis).
Authors: Ishutina N. A. , Andrievskaya I. A.
Published: September 2022

In recent years, the understanding of the mechanisms involved in the regulation of lipoapoptosis signaling pathways has expanded considerably. However, many mechanisms of apoptosis induction by lipids as well as molecules mediating intracellular and systemic signals belonging to AOS/enzyme-dependent phospholipid metabolites are not completely clear.

This review summarizes the current understanding of the mechanisms of apoptotic cell death induction by some lipid molecules. Literature search was performed in the database “PubMed”, “eLIBRARY” using key words: “apoptosis”, “lipids”, “fatty acids”, “eicosanoids”, “reactive oxygen species”.

A brief characterization of the signaling pathways of apoptosis is given. The role of reactive oxygen species and their dependent products of lipid peroxidation in the regulation of the main signaling pathways of apoptosis are shown. Particular attention is paid to the product of phospholipid metabolism – 4-hydroxynonenal.

Pro- and anti-apoptotic effects of some prostaglandins are demonstrated. Arguments are presented that prostaglandins of series J and D are pro-apoptotic in most cells, and this effect depends on activation of the prostanoid receptor DP2 and on reduction of AKT kinase activity. In contrast, the E-series prostaglandins and hydroxyecosatetraenoic acid act opposite to the J-series and D-series prostaglandins, reducing apoptosis by activating AKT and increasing Bcl-2 protein expression.

The role of individual fatty acids involved in the initiation and transduction of pro-apoptotic and anti-apoptotic signals is assessed. It was shown that saturated fatty acids have the maximum damaging potential than their unsaturated counterparts. An in-depth understanding and deciphering of the mechanisms by which lipids and their metabolites modulate the activation of signaling pathways of programmed cell death can help to develop therapeutic strategies to prevent a number of diseases associated with impaired regulation of apoptosis.
Use of biodegradable polycaprolactone matrix for filling bone defects (experimental study)
Authors: Popkov A. V. , Gorbach E. N. , Kononovich N. A. , Tverdokhlebov S. I. , Bolbasov E. N. , Popkov D. A. , Gorbach E. S.
Published: September 2022

Background. There are unresolved issues in bone defect management associated with complications, invasiveness and long duration of treatment. The use of elastic implants made of bioactive biodegradable materials that take any form of defect could close many of them.

The aim. To investigate features of reparative regeneration in filling bone defects with an elastic degradable implant made of polycaprolactone (PCL) with and without hydroxyapatite (HA).

Materials and methods. The study was carried out on 10 adult mongrel dogs. A non-through cylindrical hole, 4 mm in diameter and 10 mm deep, was modeled in the upper third of the diaphysis of the tibia. The defects thus formed were filled with an elastic degradable implant made of polycaprolactone. In Group 1, HA was not added to polycaprolactone, while HA was added in dogs of Group 2. Radiographic and histological methods were used to study the results.

Results. It was found that the tested materials did not cause toxic and allergic reactions, both local and general, during intravital observations and in post-mortem anatomical preparations. After 28 days in both series, the implant biodegraded and was replaced by bone tissue. The proportion of the bone component and the numerical density of microvessels in the defect zone in Group 2 were significantly higher than in Group 1.

Conclusion. Elastic implants produced of polycaprolactone by electrospinning are biologically compatible, biodegradable and can be used to heal bone defects. Hydroxyapatite that was added stimulates the activity of osteogenesis.
Nanоbiocomposite based on dihydroquercetin and arabinogalactan in the form of a gel for external use as a means for the treatment of chronic venous insufficiency in an experiment
Authors: Kovalskaya G. N. , Kolmakova E. S. , Nikiforov S. B. , Lozovskaya E. A. , Artemieva A. V.
Published: September 2022

Background. Due to the high prevalence of chronic venous insufficiency among the population, with a decrease in the quality of life of patients and their early disability, there is a need to develop modern effective and safe means for the prevention and treatment of this pathology. We have developed the optimal composition and technology of a gel for external use based on a nanobiocomposite of dihydroquercetin and arabinogalactan, which has a venoprotective effect. The article presents data on the results of a preclinical study of the safety and specific activity of the gel.

The aim. To study the specific activity (decongestant, antitranssudative action) and safety of a gel for external use based on nanobiocomposite of dihydroquercetin and arabinogalactan used for the treatment of chronic venous insufficiency in the framework of preclinical studies.

Materials and methods. The object of the study was a gel for external use based on dihydroquercetin and arabinogalactan nanobiocomposite. The study was conducted on 32 white male rats of the same age, for 15 days. The study of the pharmacological activity of a gel based on a nanobiocomposite of dihydroquercetin and arabinogalactan, was carried out on a model of acute venous stagnation in the tail of a rat (edema of non-inflammatory genesis), the dynamics of tail volume growth in the experimental and control group of animals was evaluated. The irritant effect of the gel on the skin of animals was also determined, the permeability of the capillaries of the skin was determined.

Results. When studying the pharmacological activity of the gel on a model of acute venous stagnation in the tail, it was shown that a soft dosage form for external use developed on the basis of nanobiocomposite of dihydroquercetin and arabinogalactan has decongestant and antitranssudative activity. The presence of a locally irritating effect in the gel under study has not been established in the framework of the experiment.

Conclusion. In the course of preclinical study of the gel of the nanobiocomposite dihydroquercetin and arabinogalactan on laboratory animals, its antitranssudative activity and safety have been proven.
Analysis of intra annual spatial dynamics of community-aсquired pneumonia incidence in the urban environment
Authors: Kravchenko N. A. , Galyos D. A. , Khakimova M. I. , Botvinkin A. D.
Published: September 2022

Background. The spread of community-acquired pneumonia (CAP) in children and adults is interconnected and conditioned by natural, climatic and social factors.

The aim. To assess the relationship between the incidences of CAP in different seasons of the year with the location of educational institutions in the urban settlement.

Materials and methods. A cross-sectional study of the spatial distribution and seasonal dynamics of CAP cases in 2015 in a Siberian city with a population of more than 600 thousand people was carried out. Using GIS, 787 cases of CAP were analyzed among children of preschool and school age and adults. For statistical processing, 111 analyzed territorial units (ATUs) with an area of 250 m2 each were allocated on the maps. The dynamics of morbidity was assessed by weeks and seasons of the year among different age groups.

Results. There was a direct moderate correlation between the number of CAP cases registered during the year with the number of schools and preschool educational institutions in ATU (r = 0.59; p < 0.001). ATUs with the presence and absence of educational institutions differed in the number of epidemic foci of CAP among the total population in winter and spring. The maximum number of cases of CAP among children and adults was registered in the second half of winter (weeks 3–13), the minimum – in the summer months (weeks 25–34).

Conclusions. GIS analysis confirms the more frequent registration of CAP diseases among the total population in urban areas with educational institutions. There was established a direct moderate correlation between the incidence of CAP in children and adults by weeks of the year. Statistically significant differences in the number of cases in areas with and without educational institutions were noted in seasons with a higher incidence (autumn and winter).
Chronic scrotal pain: Pathogenesis, clinical phenotypes and modern treatment concept (clinical lecture)
Authors: Lelyavin K. B.
Published: September 2022

Chronic scrotal pain (CSP) is a general term, which defines variety of problems causing discomfort or pain in the scrotum, which can be caused by the problems with testicles and other structures of the scrotum: epididymis, vas deferens, paratesticular structures. For a practicing urologist, the diagnosis and treatment of chronic scrotal pain is always a difficult task due to the many reasons for its appearance and the variety of clinical symptoms. CSP is a widespread but poorly understood condition, the etiology of which often can not be identified. Pain localized in the scrotum makes up 38.8 % of all cases of chronic men’s pelvic pain. From 2.5 to 4.8 % of all visits to the urologist relate to CSP syndrome. Primary scrotal pain syndrome is not associated with infection or other local pathological processes that could cause pain. The treatment of chronic scrotal pain is challenging because the pain often does not react to the traditional treatments.

The purpose of this lecture is to draw the attention of urologists, general practitioners, and everyone who is interested in the problem of treating chronic scrotal pain to the possibilities of modern medicine in solving this multidisciplinary problem.
Effects of emissions from forest fires on the morphofunctional state of reproductive system of white rats
Authors: Novikov M. A.
Published: September 2022

Introduction. At present, considering active participation of people in the elimination of wildfires, the study of the effects of smoke on the reproductive system is an urgent scientific problem.

Materials and methods. Sexually mature outbred male rats were exposed to a daily four-hour inhalation exposure to smoke for one month. Immediately after the end of the exposure, some of the animals were removed from the experiment, and some were left to survive for two months. The study on testicular samples included counting the total number of spermatogonia, the number of tubules with desquamated epithelium, as well as determining the spermatogenesis index and the number of Leydig cells.

Results. The effect of forest fire smoke on the reproductive system of model animals (outbred laboratory rats, males) was characterized by a decrease in the spermatogenesis index with a simultaneous decrease in the percentage of spermatogonia and the number of Leydig interstitial cells. The indices of the reproductive system of animals left for survival did not differ from the control values.

Discussion. The results of this study suggest that prolonged exposure to combustion products released during a forest fire negatively affects the reproductive function of male laboratory rats examined immediately after the end of the exposure. After the course of the standard cycle of spertatogenesis, the indicators characterizing the development of sperm and the generation of male sex hormones are restored to normal, which indicates a high plasticity of the male reproductive system in response to the adverse environmental factor – smoke of forest fires.
Hormonal characteristics of androgen status and their relationship with the anthropometric and metabolic parameter in men depending on the severity of hypertension
Authors: Yankovskaya S. V. , Kuzminova O. I. , Pinkhasov B. B. , Lutov Yu. V. , Selyatitskaya V. G.
Published: September 2022

Background. According to the literature data, long-term and poorly controlled hypertension (HTN) leads to target organs damage, and in some cases, to the development of associated diseases, the severity of which in men may be partly due to the characteristics of the androgenic status.

The aim: to reveal the features of hormonal indicators of androgen status and their relationship with the anthropometric and metabolic characteristics of the therapeutic clinic male patients, depending on the severity of HTN.

Materials and methods. 296 men aged 59,0 [54,0; 65,0] years with confirmed HTN were examined. All study participants in the morning on an empty stomach underwent anthropometry, determination of metabolic and androgenic status, and assessment of comorbid burden. Depending on the severity of hypertension, all patients were divided into two groups (G): G1 (n = 134) – patients with hypertension without a history of coronary artery disease or stroke; G2 (n = 162) – patients with hypertension with a history of ischemic heart disease (IHD) and/or stroke.

Results. In male patients of G2 with severe HTN, a decrease in the levels of free testosterone (FT) and, to a greater extent, dehydroepiandrosterone sulfate (DHEA-S), as well as total cholesterol, high and low density lipoproteins, was revealed. The correlation analysis performed revealed statistically significant negative correlations between the levels of total testosterone (TT) and FT with body mass index, the value of the ratio of waist circumference to hips, only the level of FT – with the presence of IHD, chronic heart failure (CHF), disorders of carbohydrate metabolism and abdominal type of fat distribution, and the level of DHEA-S – with the presence of IHD and CHF.

Conclusion. A decrease in FT and DHEA-S is associated with early progression of atherosclerosis and the risk of developing HTN-associated cardiovascular events, which can aggravate the course of HTN.
Prerenal kidney damage in patients with local cold injury
Authors: Mikhailichenko M. M. , Shapovalov K. G. , Mudrov V. A. , Mikhaylichenko S. I. , Mikhaylichenko A. V. , Hanina Yu. S. , Mikhailichenko Yu. V.
Published: September 2022

Introduction. Important links in the pathogenesis of cold alterations are vascular damage and powerful systemic alterations. The presence of premorbid pathology and the duration of the wound process negatively affects to the function of most organs and systems, including the kidneys. Renal insufficiency in patients with frostbite develops in the acute period of cold damage. This is indicated by a decrease in the amount of urine and an increase in creatinine levels in victims with frostbite. In this regard, the identification and analysis of the dynamics of new markers of renal dysfunction in patients with frostbite is promising both from a scientific and practical point of view.

The aim. To investigate the dynamics of changes in serum creatinine, NGAL and cystatin C levels in patients with local cold trauma.

Materials and methods. The study included 60 patients with frostbite of the III–IV degree of distal limb segments. The study was carried out depending on the volume of the lesion and the timing from the moment of cryoalteration.

The results of the study. In patients with grade III–IV frostbite, an increase in the level of lipocalin and serum creatinine was detected in the blood. The concentration of lipocalin and serum creatinine is directly proportional to the volume of cold-affected tissues. Indicators of lipocalin and serum creatinine decrease in the late stages of cryopreservation. The level of cystatin C significantly decreases during all periods of frostbite; the concentration of the latter does not depend on the severity of cryopreservation.
Comprehensive analysis of the results of surgical treatment of patients with degenerative diseases of the lumbar spine using rigid fixation systems
Authors: Krivoschein A. E. , Konev V. P. , Kolesov S. V. , Erofeev S. A. , Moskovskiy S. N. , Byvaltsev V. A.
Published: September 2022

Introduction. According to the literature, the development of adjacent-level syndrome 10 years after posterior rigid stabilization is noted in 6.7–80 % of patients, of which 24 % require revision surgery.

The aim: to conduct a comprehensive analysis of the results of surgical treatment of patients with degenerative diseases of the lumbar spine using rigid fixation systems.

Materials and methods. A multicenter retrospective study of the results of surgical treatment of 268 patients with degenerative-dystrophic diseases of the lumbar spine, who underwent mono- or bisegmental decompression-stabilizing intervention with the implementation of the TLIF (Transforaminal Lumbar Interbody Fusion) technique and open transpedicular rigid fixation, was conducted. The study included radiography, MRI and CT (in 2-energy mode) of intervertebral discs and isolated facet degeneration of the upper adjacent level.

Results and discussion. The combination of the initial degeneration of the adjacent spinal motion segment in the form of disc degeneration of grade III and higher according to Pfirrmann with threshold values of the density of the outer cartilaginous plate from 161.7 ± 18.8 to 164.8 ± 14.2 HU, the density of the outer facet – from 702.43 ± 12.3 to 713.65 ± 13.6 HU and the density of the inner facet – from 580.5 ± 11.6 to 582.1 ± 15.1 HU, as well as with signs of segmental instability of the adjacent segment can be considered as risk factors for the development of its degeneration. With the progression of degeneration of the upper intervertebral disc, revision interventions were performed within 12–60 months after surgery.

Conclusion. Bisegmental stabilization with signs of initial degeneration in the intervertebral disc and facet joints in the upper segment has proven its clinical and instrumental effectiveness in the period of 36 months and reduces the risks of developing degenerative disease of the adjacent disc.
ANALISIS FAKTOR - FAKTOR YANG MEMPENGARUHI LOYALITAS PELANGGAN “SCARLETT WHITENING BODYLOTION”
Authors: Yani Ranti April , Sinambela Mathora Tatiana , Lubis Irsyad
Published: September 2022

This study aims to examine whether the factors studied affect customer loyalty in using Scarlett Whitening body lotion. The population used in this study were students majoring in management at the Univercity Pembangunan Panca Budi Medan with the criteria for women from the 2018-2021 class. The sample required is 81 respondents. Sampling used in this study is non-probability sampling. The type of data used in this study is primary data, namely by collecting data through questionnaires. The data analysis technique used in this research is multiple linear regression. Thus partially and simultaneously, customer satisfaction, product quality, and brand image have a significant effect on customer loyalty Scarlett Whitening bodylotion
ANALISIS KELAYAKAN UNIT USAHA PENGELOLAAN SAMPAH PADA BUMDESA "SIDO MAKMUR", DESA - KECAMATAN GETASAN, KABUPATEN SEMARANG
Authors: Istiyani Ambar , Lisaputra Prasetyo Suryahadi Mahendra
Published: September 2022

Based on Law No. 6 of 2014 concerning the Village, villages can form a business entity to improve the welfare of their people. The Village Owned Enterprise (BUM Desa) Sido Makmur in Getasan Village, Semarang Regency, has some business units, including the Waste Management Business Unit. This unit has two stages of activities: Phase I is Waste Collection, and Phase II is Waste Segregation which includes converting the waste into goods with economic value. The Phase I program has been running since 2020 in one of the hamlets, and Phase II will soon be implemented. However, the BUM Desa Sido Makmur has never conducted a feasibility study on this business unit. A feasibility study can help BUM Desa understand whether a business can be continued or not and provide input for future business development. This article analysis the feasibility of the Waste Management Business Unit at BUM Desa Sido Makmur in terms of Legal, Market and Marketing, Human Resource Management, Technical and Technology, Environment, and Financial Aspects. Primary and secondary data in qualitative and quantitative data were analyzed using business feasibility analysis. The study results show that the Waste Management Business Unit in  BUM Desa Sido Makmur is feasible. However, for this business unit to develop further, Phase II of waste management, namely converting waste into goods with economic value, must be done immediately by training village communities. In addition, it is necessary to expand business units' operations, not only in one hamlet but also in other hamlets.