bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of Early and Enhanced Respiratory Physiotherapy and Mobilization after On-Pump Cardiac Surgery: A Prospective Randomized Controlled Trial
Authors: Afxonidis Georgios , Moysidis Dimitrios V. , Papazoglou Andreas S. , Tsagkaris Christos , Loudovikou Anna , Tagarakis Georgios , Karapanagiotidis Georgios T. , Alexiou Ioannis A. , Foroulis Christophoros , Anastasiadis Kyriakos
Published: December 2021

Background: This randomized controlled trial aimed to investigate the influence of physical activity and respiratory physiotherapy on zero postoperative day on clinical, hemodynamic and respiratory parameters of patients undergoing cardiac surgeries under extracorporeal circulation. Methods: 78 patients undergoing coronary artery bypass graft (CABG) or/and valvular heart disease surgeries were randomly assigned into an early and enhanced physiotherapy care group (EEPC group; n = 39) and a conventional physiotherapy care group (CPC group; n = 39). Treatment protocol for the EEPC group included ≤3 Mets of physical activity and respiratory physiotherapy on zero post-operative day and an extra physiotherapy session during the first three post-operative days, whereas the CPC group was treated with usual physiotherapy care after the first post-operative day. The length of hospital and intensive care unit (ICU) stay were set as the primary study outcomes, while pre- and post-intervention measurements were also performed to assess the oxymetric and hemodynamic influence of early mobilization and physiotherapy. Results: Participants’ mean age was 51.9 ± 13.8 years. Of them 48 (61.5%) underwent CABG. Baseline and peri-procedural characteristics did not differ between the two groups. The total duration of hospital and ICU stay were significantly higher in the CPC group compared to the EEPC group (8.1 ± 0.4 days versus 8.9 ± 0.6 days and 25.4 ± 3 h versus 23.2 ± 0.6 h, p < 0.001, respectively). Statistically significant differences in pre-intervention oxygen saturation, and post-intervention PO2 and lactate levels were also observed between the two groups (p = 0.022, 0.027 and 0.001, respectively). Conclusion: In on-pump cardiac surgery, early and enhanced post-procedural physical activity (≤3 METS) can prevent a prolonged ICU stay and decrease the duration of hospitalization while ameliorating post-operative hemodynamic and oxymetric parameters.
Development of Predictive Geoarchaeological Models to Locate and Assess the Preservation Potential of Submerged Prehistoric Sites Using Remote Sensing, Palaeoenvironmental Analysis, and GIS
Authors: Gregory David John , Bennike Ole , Jensen Jørn Bo , Rasmussen Peter , Al-Hamdani Zyad
Published: December 2021

Using the Mesolithic site of Tudse Hage in the Great Belt of Denmark, this paper proposes a generic stepwise process to create geoarchaeological models that output seamless morphology maps in a GIS. This was achieved using remote sensing databases and the collection of marine geophysical data, above and below the seabed. On the basis of these data, key areas, with sediment sequences representative of the postglacial transgression surfaces, were identified. Core samples were taken for palaeoenvironmental analysis and dating that enabled a reconstruction of the relative sea-level changes. Using this information, palaeogeographic coastline maps of the Kongemose, late Kongemose, Ertebølle, and Neolithic periods in the Tudse Hage area were prepared, and potential hotspots for archaeological sites were proposed. Since their inundation, submerged prehistoric archaeological sites have been, and are, dynamic, with anthropogenic and natural processes affecting their stability and preservation. With the advocation of in situ preservation as a means of managing underwater cultural heritage, predicting where sites have survived these processes, and where they can be found, in advance of subsea development or other anthropogenic exploitation, is essential. Future natural threats to sites preserved in situ were determined through the modelling of seabed currents and sediment erosion.
Exercise Training for Multiple Sclerosis: A Narrative Review of History, Benefits, Safety, Guidelines, and Promotion
Authors: Learmonth Yvonne Charlotte , Motl Robert Wayne
Published: December 2021

Background: There have been significant advances in the medical treatment and management of multiple sclerosis pathogenesis, relapse and disease progression over the past 30 years. There have been advancements in the symptomatic treatment of multiple sclerosis, including management of secondary multiple sclerosis expressions such as walking, cognitive dysfunction, fatigue and depression. Scientific evidence and expert opinion suggest that exercise may be the single most effective non-pharmacological symptomatic treatment for multiple sclerosis. This article presents the historical context of exercise training within the multidisciplinary management of multiple sclerosis. We guide neurologists and healthcare providers on the recommended prescription of exercise and practical, theoretical methods to overcome barriers to exercise. Method: We undertook a critical search of the historical and current literature regarding exercise and multiple sclerosis from the viewpoint of exercise promotion by neurologists and the multidisciplinary care team. Results: We highlight the ever-strengthening body of research indicating that exercise is safe and effective for improving symptoms of multiple sclerosis. Further, exercise training may be necessary for reducing disease progression. Conclusion: We seek to encourage neurologists and specialists in multidisciplinary healthcare teams to prescribe and promote exercise at diagnosis and across all stages of the disease trajectory using prescriptive guidelines as part of comprehensive MS care. Available tools include clinical education to dispel any historical myths related to exercise in multiple sclerosis, clinical exercise guidelines and behaviour change theory to overcome patients barriers to exercise.
Static and Impact Response of a Single-Span Stone Masonry Arch
Authors: Pulatsu Bora , Gonen Semih , Lourenço Paulo B.
Published: December 2021

Unreinforced masonry structures are susceptible to man-made hazards such as impact and blast loading. However, the literature on this subject mainly focuses on masonry wall behavior, and there is a knowledge gap about the behavior of masonry arches under high-strain loading. In this context, this research aims to investigate both quasistatic and impact response of a dry-joint stone masonry arch using the discrete element method. Rigid blocks with noncohesive joint models are adopted to simulate dry-joint assemblages. First, the employed modeling strategy is validated utilizing the available experimental findings, and then sensitivity analyses are performed for both static and impact loading, considering the effect of joint friction angle, contact stiffness, and damping parameters. The outcomes of this research strengthen the existing knowledge in the literature regarding the computational modeling of masonry structures that are subjected to usual and extreme loading conditions. The results highlight that applied discontinuum-based numerical models are more sensitive to stiffness parameters in high-strain loading than static analysis.
Extending the Quality of Secure Service Model to Multi-Hop Networks
Authors: Simon Paul M. , Graham Scott
Published: December 2021

Rarely are communications networks point-to-point. In most cases, transceiver relay stations exist between transmitter and receiver end-points. These relay stations, while essential for controlling cost and adding flexibility to network architectures, reduce the overall security of the respective network. In an effort to quantify that reduction, we extend the Quality of Secure Service (QoSS) model to these complex networks, specifically multi-hop networks. In this approach, the quantification of security is based upon probabilities that adversarial listeners and disruptors gain access to or manipulate transmitted data on one or more of these multi-hop channels. Message fragmentation and duplication across available channels provides a security performance trade-space, with its consequent QoSS. This work explores that trade-space and the corresponding QoSS model to describe it.
The Effects of Bubble Scattering on Sound Propagation in Shallow Water
Authors: Liu Ruoyun , Li Zhenglin
Published: December 2021

As sea waves break, a bubble layer forms beneath the sea surface. The bubble scattering affects sound propagation, thus influencing the accuracy of sound field prediction. This paper aims to investigate the effects of bubble scattering on the statistical characteristics of the sound field, the distribution of transmission loss (TL), and the average scattering attenuation in shallow water. A bubble layer model based on the bubble spectrum and a parallel Parabolic Equation (PE) model are combined to calculate and analyse the sound field in the marine environment with bubbles. The effects of the bubble layer are then compared with those of the fluctuant sea surface. The results show that the bubble scattering causes additional energy loss and random fluctuations of the sound field. The TL distribution properties and the average scattering attenuation are related to the wind speed, range, frequency, and source position relative to the negative gradient sound speed layer in shallow water. The comparison demonstrates that the random variation caused by the fluctuation of the sea surface is more significant than that caused by bubbles, and the energy loss caused by bubble scattering is more significant than the fluctuant sea surface under strong wind conditions.
Synthesis, Fungitoxic Activity against Botrytis cinerea and Phytotoxicity of Alkoxyclovanols and Alkoxyisocaryolanols
Authors: de Almeida Pinto Bracarense Adriana , Ascari Jociani , de Souza Giovanni Gontijo , Oliveira Thays Silva , Ruano-González Antonio , Pinto Ana A. , Boaventura Maria Amélia Diamantino , Takahashi Jacqueline Aparecida , Collado Isidro G. , Durán-Patrón Rosa , Macías-Sánchez Antonio J.
Published: December 2021

Clovane and isocaryolane derivatives have been proven to show several levels of activity against the phytopathogenic fungus Botrytis cinerea. Both classes of sesquiterpenes are reminiscent of biosynthetic intermediates of botrydial, a virulence factor of B. cinerea. Further development of both classes of antifungal agent requires exploration of the structure–activity relationships for the antifungal effects on B. cinerea and phytotoxic effects on a model crop. In this paper, we report on the preparation of a series of alkoxy-clovane and -isocaryolane derivatives, some of them described here for the first time (2b, 2d, 2f–2h, and 4c–4e); the evaluation of their antifungal properties against B. cinerea, and their phytotoxic activites on the germination of seeds and the growth of radicles and shoots of Lactuca sativa (lettuce). Both classes of compound show a correlation of antifungal activity with the nature of side chains, with the best activity against B. cinerea for 2d, 2h, 4c and 4d. In general terms, while 2-alkoxyclovan-9-ols (2a–2e) exert a general phytotoxic effect, this is not the case for 2-arylalkoxyclovan-9-ols (2f–2i) and 8-alkoxyisocaryolan-9-ols (4a–4d), where stimulating effects would make them suitable candidates for application to plants.
Distribution and Assembly Processes of Soil Fungal Communities along an Altitudinal Gradient in Tibetan Plateau
Authors: Hussain Sarfraz , Liu Hao , Liu Senlin , Yin Yifan , Yuan Zhongyuan , Zhao Yuguo , Cao Hui
Published: December 2021

In soil ecosystems, fungi exhibit diverse biodiversity and play an essential role in soil biogeochemical cycling. Fungal diversity and assembly processes across soil strata along altitudinal gradients are still unclear. In this study, we investigated the structure and abundance of soil fungal communities among soil strata and elevational gradients on the Tibetan Plateau using Illumina MiSeq sequencing of internal transcribed spacer1 (ITS1). The contribution of neutral and niche ecological processes were quantified using a neutral community model and a null model-based methodology. Our results showed that fungal gene abundance increased along altitudinal gradients, while decreasing across soil strata. Along with altitudinal gradients, fungal α-diversity (richness) decreased from surface to deeper soil layers, while β-diversity showed weak correlations with elevations. The neutral community model showed an excellent fit for neutral processes and the lowest migration rate (R2 = 0.75). The null model showed that stochastic processes dominate in all samples (95.55%), dispersal limitations were dominated at the surface layer and decreased significantly with soil strata, while undominated processes (ecological drift) show a contrary trend. The log-normal model and the null model (βNTI) correlation analysis also neglect the role of niche-based processes. We conclude that stochastic dispersal limitations, together with ecological drifts, drive fungal communities.
Exo Journalism: A Conceptual Approach to a Hybrid Formula between Journalism and Artificial Intelligence
Authors: Tejedor Santiago , Vila Pere
Published: December 2021

The irruption of artificial intelligence (AI) and automated technology has substantially changed the journalistic profession, transforming the way of capturing, processing, generating, and distributing information; empowering the work of journalists by modifying the routines and knowledge required by information professionals. This study, which conceptualizes the “exo journalism” on the basis of the impact of AI on the journalism industry, is part of a research project of the Observatory for Information Innovation in the Digital Society (OI2). The results, derived from documentary research supported by case studies and in-depth interviews, propose that AI is a source of innovation and personalization of journalistic content and that it can contribute to the improvement of professional practice, allowing the emergence of a kind of "exo journalist", a conceptual proposal that connects the possibilities of AI with the needs of journalism’s own productive routines. The end result is the enhancement of the journalist’s skills and the improvement of the news product. The research focuses on conceptualizing a kind of support and complement for journalists in the performance of their tasks based on the possibilities of AI in the automatic generation of content and data verification.
Performance of Multifunctional Smart PV-Based Domestic Distributed Generator in Dual-Mode Operation
Authors: Chandrasekaran Kumar , Sahayam Jasper John , Thanasingh Sundarsingh Jebaseelan Somasundaram David , Ramalingam Sripriya , Fayek Hady H. , Ravichandran Nagananthini , Rusu Eugen
Published: December 2021

This article briefs about a smart multifunctional single-phase inverter control for a domestic solar photo voltaic (PV)-based distributed generation that can work in both a grid-connected mode and an islanded mode by making the inverter mimic the operation of a synchronous generator. The control objectives were threefold: to provide the required active and reactive power for normal operating conditions and under varying operating conditions, to maintain the rated voltage and the rated frequency for the islanded mode, and to switch between the two modes of operation with the least amount of disturbance for the system while behaving as a virtual synchronous generator (VSG). The control structure is divided into three major loops: the outermost loop responsible for power control, the middle loop responsible for voltage control, and the innermost loop responsible for current control. The proposed control methodology incorporates the functionalities of the grid-connected and the islanded-mode control into a single complex structure and thus provides support to the grid under abnormal conditions while providing good-quality power to consumers under grid failure. The efficacy of the system is good. The operation under various modes were simulated in MATLAB Simulink, and the proportional integral (PI) controllers used for current controllers were tuned using particle swarm optimization (PSO). It can be concluded that the control structure becoming complex is benefitted by the added advantages of the smart PV system. The smart domestic PV system helps the prosumer to actively provide frequency support and voltage support, adding frequency support to the existing multifunctional PV systems.
Symmetrical Augmented System of Equations for the Parameter Identification of Discrete Fractional Systems by Generalized Total Least Squares
Authors: Ivanov Dmitriy , Zhdanov Aleksandr
Published: December 2021

This paper is devoted to the identification of the parameters of discrete fractional systems with errors in variables. Estimates of the parameters of such systems can be obtained using generalized total least squares (GTLS). A GTLS problem can be reduced to a total least squares (TLS) problem. A total least squares problem is often ill-conditioned. To solve a TLS problem, a classical algorithm based on finding the right singular vector or an algorithm based on an augmented system of equations with complex coefficients can be applied. In this paper, a new augmented system of equations with real coefficients is proposed to solve TLS problems. A symmetrical augmented system of equations was applied to the parameter identification of discrete fractional systems. The simulation results showed that the use of the proposed symmetrical augmented system of equations can shorten the time for solving such problems. It was also shown that the proposed system can have a smaller condition number.
A Rapid Digital PCR System with a Pressurized Thermal Cycler
Authors: Chen Xuee , Song Qi , Zhang Beini , Gao Yibo , Lou Kai , Liu Yiteng , Wen Weijia
Published: December 2021

We designed a silicon-based fast-generated static droplets array (SDA) chip and developed a rapid digital polymerase chain reaction (dPCR) detection platform that is easy to load samples for fluorescence monitoring. By using the direct scraping method for sample loading, a droplet array of 2704 microwells with each volume of about 0.785 nL can be easily realized. It was determined that the sample loading time was less than 10 s with very simple and efficient characteristics. In this platform, a pressurized thermal cycling device was first used to solve the evaporation problem usually encountered for dPCR experiments, which is critical to ensuring the successful amplification of templates at the nanoliter scale. We used a gradient dilution of the hepatitis B virus (HBV) plasmid as the target DNA for a dPCR reaction to test the feasibility of the dPCR chip. Our experimental results demonstrated that the dPCR chip could be used to quantitatively detect DNA molecules. Furthermore, the platform can measure the fluorescence intensity in real-time. To test the accuracy of the digital PCR system, we chose three-channel silicon-based chips to operate real-time fluorescent PCR experiments on this platform.
Recent Advancements in the Development of Anti-Breast Cancer Synthetic Small Molecules
Authors: Elkaeed Eslam B. , Salam Hayam A. Abd El , Sabt Ahmed , Al-Ansary Ghada H. , Eldehna Wagdy M.
Published: December 2021

Among all cancer types, breast cancer (BC) still stands as one of the most serious diseases responsible for a large number of cancer-associated deaths among women worldwide, and diagnosed cases are increasing year by year worldwide. For a very long time, hormonal therapy, surgery, chemotherapy, and radiotherapy were used for breast cancer treatment. However, these treatment approaches are becoming progressively futile because of multidrug resistance and serious side effects. Consequently, there is a pressing demand to develop more efficient and safer agents that can fight breast cancer belligerence and inhibit cancer cell proliferation, invasion and metastasis. Currently, there is an avalanche of newly designed and synthesized molecular entities targeting multiple types of breast cancer. This review highlights several important synthesized compounds with promising anti-BC activity that are categorized according to their chemical structures.
Anti-Fatigue Peptides from the Enzymatic Hydrolysates of Cervus elaphus Blood
Authors: Lv Jun-Jiang , Liu Yan , Zeng Xiao-Yan , Yu Jia , Li Yan , Du Xiao-Qin , Wu Zhong-Bao , Hao Shi-Lei , Wang Bo-Chu
Published: December 2021

Red deer (Cervus elaphus) blood is widely used as a health product. Mixed culture fermentation improves the flavor and bioavailability of deer blood (DB), and both DB and its enzymatic hydrolysates exhibit anti-fatigue activities in vivo. To elucidate the bioactive ingredients, enzymatic hydrolysates were fractioned into different peptide groups using reversed phase resin chromatography, and then evaluated using an exhaustive swimming mice model to assess swimming time and biochemical parameters. The structures of the bioactive peptides were elucidated by high performance liquid chromatography with tandem mass detection. Thirty-one compounds were identified as glutamine or branched-chain amino acids containing short peptides, of which Val-Ala-Asn, Val-Val-Ser-Ala, Leu(Ile)-Leu(Ile)-Val-Thr, Pro-His-Pro-Thr-Thr, Glu-Val-Ala-Phe and Val-Leu(Ile)-Asp-Ala-Phe are new peptides. The fractions containing glutamine or valine short peptides, Ala-Gln, Val-Gln, Val-Val-Ser-Ala, Val-Leu(Ile)-Ser improved exercise endurance by increasing hepatic glycogen (HG) storage. The peptides group containing Leu(Ile)-Leu(Ile), Asp-Gln, Phe- Leu(Ile), Val-Val-Tyr-Pro contributed to decreased muscle lactic acid (MLA)accumulation and to an increase in HG. The anti-fatigue activities of DB hydrolysates were attributed to the synergistic effects of different types of peptides.
Aroma Properties of Cocoa Fruit Pulp from Different Origins
Authors: Bickel Haase Thomas , Schweiggert-Weisz Ute , Ortner Eva , Zorn Holger , Naumann Susanne
Published: December 2021

Cocoa pulp occurs as a by-product of cocoa bean production and can be repurposed to different food applications, such as jams, fruit preparations and beverages, improving the sustainability of cocoa production, as well as the livelihoods of cocoa farmers. In this work, aroma-active compounds of fresh cocoa fruit pulps from different origins were investigated by applying aroma extract dilution analyses in combination with gas chromatography-mass spectrometry/olfactometry for identification. In total, 65 aroma-active compounds were determined in four different pulps originating from Indonesia, Vietnam, Cameroon, and Nicaragua. Vietnamese pulp showed the highest number of aroma-active regions, while Cameroonian pulp accounted for the lowest. Moreover, Cameroonian cocoa pulp showed the lowest FD factors. Overall, the odorants with the highest FD factors were trans-4,5-epoxy-(E)-decenal, 2- and 3-methylbutanoic acid, 3-(methylthio)propanal, 2-isobutyl-3-methoxypyrazine, (E,E)-2,4-nonadienal, (E,E)-2,4-decadienal, 4-vinyl-2-methoxyphenol, δ-decalactone, 3-hydroxy-4,5-dimethylfuran-2(5H)-one, dodecanoic acid, and linalool. This study provides insights into the aroma composition of fresh cocoa pulp from different origins for future food applications.
A Dispersion Corrected DFT Investigation of the Inclusion Complexation of Dexamethasone with β-Cyclodextrin and Molecular Docking Study of Its Potential Activity against COVID-19
Authors: Belhocine Youghourta , Rahali Seyfeddine , Allal Hamza , Assaba Ibtissem Meriem , Ghoniem Monira Galal , Ali Fatima Adam Mohamed
Published: December 2021

The encapsulation mode of dexamethasone (Dex) into the cavity of β-cyclodextrin (β-CD), as well as its potential as an inhibitor of the COVID-19 main protease, were investigated using density functional theory with the recent dispersion corrections D4 and molecular docking calculations. Independent gradient model and natural bond orbital approaches allowed for the characterization of the host–guest interactions in the studied systems. Structural and energetic computation results revealed that hydrogen bonds and van der Waals interactions played significant roles in the stabilization of the formed Dex@β-CD complex. The complexation energy significantly decreased from −179.50 kJ/mol in the gas phase to −74.14 kJ/mol in the aqueous phase. A molecular docking study was performed to investigate the inhibitory activity of dexamethasone against the COVID-19 target protein (PDB ID: 6LU7). The dexamethasone showed potential therapeutic activity as a SARS CoV-2 main protease inhibitor due to its strong binding to the active sites of the protein target, with predicted free energy of binding values of −29.97 and −32.19 kJ/mol as calculated from AutoDock4 and AutoDock Vina, respectively. This study was intended to explore the potential use of the Dex@β-CD complex in drug delivery to enhance dexamethasone dissolution, thus improving its bioavailability and reducing its side effects.
Behavioral and Metabolic Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation in Obese Male Rats
Authors: Subias-Gusils Alex , Álvarez-Monell Adam , Boqué Noemí , Caimari Antoni , Del Bas Josep M. , Mariné-Casadó Roger , Solanas Montserrat , Escorihuela Rosa M.
Published: December 2021

Diet-induced obesity models are widely used to investigate dietary interventions for treating obesity. This study was aimed to test whether a dietary intervention based on a calorie-restricted cafeteria diet (CAF-R) and a polyphenolic compound (Oleuropein, OLE) supplementation modified sucrose intake, preference, and taste reactivity in cafeteria diet (CAF)-induced obese rats. CAF diet consists of high-energy, highly palatable human foods. Male rats fed standard chow (STD) or CAF diet were compared with obese rats fed CAF-R diet, alone or supplemented with an olive tree leaves extract (25 mg/kg*day) containing a 20.1% of OLE (CAF-RO). Biometric, food consumption, and serum parameters were measured. CAF diet increased body weight, food and energy consumption and obesity-associated metabolic parameters. CAF-R and CAF-RO diets significantly attenuated body weight gain and BMI, diminished food and energy intake and improved biochemical parameters such as triacylglycerides and insulin resistance which did not differ between CAF-RO and STD groups. The three cafeteria groups diminished sucrose intake and preference compared to STD group. CAF-RO also diminished the hedonic responses for the high sucrose concentrations compared with the other groups. These results indicate that CAF-R diet may be an efficient strategy to restore obesity-associated alterations, whilst OLE supplementation seems to have an additional beneficial effect on sweet taste function.
Nutritional Deficiencies in Celiac Disease: Current Perspectives
Authors: Verma Anil K.
Published: December 2021

Gluten-induced T-cell-mediated immune response damages the villous structure that significantly affects the functioning of the small intestinal mucosa [...]
Circadian Clock Component BMAL1 in the Paraventricular Nucleus Regulates Glucose Metabolism
Authors: Nakata Masanori , Kumari Parmila , Kita Rika , Katsui Nanako , Takeuchi Yuriko , Kawaguchi Tomoki , Yamazaki Toshiya , Zhang Boyang , Shimba Shigeki , Yada Toshihiko
Published: December 2021

It is suggested that clock genes link the circadian rhythm to glucose and lipid metabolism. In this study, we explored the role of the clock gene Bmal1 in the hypothalamic paraventricular nucleus (PVN) in glucose metabolism. The Sim1-Cre-mediated deletion of Bmal1 markedly reduced insulin secretion, resulting in impaired glucose tolerance. The pancreatic islets’ responses to glucose, sulfonylureas (SUs) and arginine vasopressin (AVP) were well maintained. To specify the PVN neuron subpopulation targeted by Bmal1, the expression of neuropeptides was examined. In these knockout (KO) mice, the mRNA expression of Avp in the PVN was selectively decreased, and the plasma AVP concentration was also decreased. However, fasting suppressed Avp expression in both KO and Cre mice. These results demonstrate that PVN BMAL1 maintains Avp expression in the PVN and release to the circulation, possibly providing islet β-cells with more AVP. This action helps enhance insulin release and, consequently, glucose tolerance. In contrast, the circadian variation of Avp expression is regulated by feeding, but not by PVN BMAL1.
The Vitamin D Decrease in Children with Obesity Is Associated with the Development of Insulin Resistance during Puberty: The PUBMEP Study
Authors: Pires Liliane Viana , González-Gil Esther M. , Anguita-Ruiz Augusto , Bueno Gloria , Gil-Campos Mercedes , Vázquez-Cobela Rocío , Pérez-Ferreirós Alexandra , Moreno Luis A. , Gil Ángel , Leis Rosaura , Aguilera Concepción M.
Published: December 2021

Obesity and cardiometabolic risk have been associated with vitamin D levels even in children. The objective of the present study was to evaluate the association between insulin resistance (IR), cardiometabolic risk factors, and vitamin D in children from prepubertal to pubertal stages. A total of 76 children from the PUBMEP study, aged 4–12 years at baseline, were included. Children were evaluated in prepubertal and pubertal stages. Anthropometric measurements and selected cardiometabolic risk biomarkers, such as plasma glucose, blood lipids, insulin, adiponectin, leptin, and blood pressure, and serum 25-hydroxyvitamin D (25(OH)D) were determined. Children were categorized by obesity degree and IR status combined before and after puberty. Paired t-test and multivariate linear regression analyses were conducted. During puberty, the increase in triacylglycerols, insulin, and HOMA-IR and the decrease in QUICKI were significantly associated with the reduction in 25(OH)D (B = −0.274, p = 0.032; B = −0.219, p = 0.019; B = −0.250, p = 0.013; B = 1.574, p = 0.013, respectively) after adjustment by BMI-z, sex, and pubertal stage. Otherwise, prepubertal non-IR children with overweight/obesity that became IR during puberty showed a significant decrease in 25(OH)D and HDL-c, and an increase in waist circumference and triacylglycerol concentrations (p < 0.05 for all) over time. These results suggest that changes in IR seem to be associated with an effect on 25(OH)D levels during puberty, especially in children with overweight.
Total Edentulism and Its Epidemiological Surveillance in Oaxaca, Mexico from 2009–2019
Authors: Martínez-Martínez Enrique , Medina-Solís Carlo , Alpuche Juan
Published: December 2021

Total edentulism is the loss of all teeth for any cause by a multifactorial process that involves biological and patient-related factors. Studies on edentulism and risk factors in Mexico are limited, and the epidemiological surveillance data is scarce and controversial since official governmental reports are not statistically representative of the country. We estimate the distribution for edentulism according to sociodemographic and socioeconomic variables in adults from a low-income state in 2003 and its progress in Mexico. We analyzed data from the National Performance Evaluation Survey in Oaxaca, Mexico, and the annual reports of the Epidemiological Surveillance System of Oral Pathologies in 2009–2019 using X2. Oaxacan patients older than 75 y.o. (17.9%, p < 0.05), those with lower schooling (11.2%), and diabetes (14.5%) presented the highest percentage of edentulism. We do not observe differences in edentulism between sex or residence (p > 0.05). From 2009 to 2019, country data reports the lowest rate of edentulism in adults over 20 y.o. (0.32%; 95% CI 0.18–0.48%) and the most affected population over 79 y.o. (7.29%; 95% CI 5.2–9.30%). As it is a cumulative phenomenon, it is necessary to establish better surveillance, prevention, and treatment programs to improve the oral health of older thus reducing edentulism.
Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles
Authors: Sokolovskaya Olga I. , Sergeeva Ekaterina A. , Golovan Leonid A. , Kashkarov Pavel K. , Khilov Aleksandr V. , Kurakina Daria A. , Orlinskaya Natalia Y. , Zabotnov Stanislav V. , Kirillin Mikhail Y.
Published: December 2021

Biodegradable and low-toxic silicon nanoparticles (SiNPs) have potential in different biomedical applications. Previous experimental studies revealed the efficiency of some types of SiNPs in tumor hyperthermia. To analyse the feasibility of employing SiNPs produced by the laser ablation of silicon nanowire arrays in water and ethanol as agents for laser tumor hyperthermia, we numerically simulated effects of heating a millimeter-size nodal basal-cell carcinoma with embedded nanoparticles by continuous-wave laser radiation at 633 nm. Based on scanning electron microscopy data for the synthesized SiNPs size distributions, we used Mie theory to calculate their optical properties and carried out Monte Carlo simulations of light absorption inside the tumor, with and without the embedded nanoparticles, followed by an evaluation of local temperature increase based on the bioheat transfer equation. Given the same mass concentration, SiNPs obtained by the laser ablation of silicon nanowires in ethanol (eSiNPs) are characterized by smaller absorption and scattering coefficients compared to those synthesized in water (wSiNPs). In contrast, wSiNPs embedded in the tumor provide a lower overall temperature increase than eSiNPs due to the effect of shielding the laser irradiation by the highly absorbing wSiNPs-containing region at the top of the tumor. Effective tumor hyperthermia (temperature increase above 42 °C) can be performed with eSiNPs at nanoparticle mass concentrations of 3 mg/mL and higher, provided that the neighboring healthy tissues remain underheated at the applied irradiation power. The use of a laser beam with the diameter fitting the size of the tumor allows to obtain a higher temperature contrast between the tumor and surrounding normal tissues compared to the case when the beam diameter exceeds the tumor size at the comparable power.
Analysis of Dynamic Characteristics for Machine Tools Based on Dynamic Stiffness Sensitivity
Authors: Li Chunhui , Song Zhiqiang , Huang Xianghua , Zhao Hui , Jiang Xuchu , Mao Xinyong
Published: December 2021

Dynamic parameters are the intermediate information of the entirety of machine dynamics. The differences between components have not been combined with the structural vibration in the cutting process, so it is difficult to directly represent the dynamic characteristics of the whole machine related to spatial position. This paper presents a method to identify sensitive parts according to the dynamic stiffness-sensitivity algorithm, which represents the dynamic characteristics of the whole machine tool. In this study, two experiments were carried out, the simulation verification experiment (dynamic experiment with variable stiffness) and modal analysis experiment (vibration test of five-axis gantry milling machine). The key modes of sensitive parts obtained by this method can represent the position-related dynamic characteristics of the whole machine. The characteristic obtained is that the inherent properties of machine-tool structure are independent of excitation. The method proposed in this paper can accurately represent the dynamic characteristics of the whole machine tool.
Construction of a Removable Partial Denture (RPD): Comparison between the Analog Procedure and the Selective Laser Melting Procedure
Authors: Pugliese Anthony , Cataneo Enrico , Fortunato Leonzio
Published: December 2021

A partial removable denture is a device that allows the patient to recover from a partial edentulism. This case report describes the realization of a chrome–cobalt partial removable denture by using two different realization methods: (1) analogic framework and (2) hybrid framework. This allowed us to compare the stability, retention as well as clasp quality of both the products and to highlight their respective advantages, disadvantages, and limitations.
RETRACTED: The Temporal-Spatial Distribution and Information-Diffusion-Based Risk Assessment of Forest Fires in China
Authors: Wu Shu
Published: December 2021

As forest fires are becoming a recurrent and severe issue in China, their temporal-spatial information and risk assessment are crucial for forest fire prevention and reduction. Based on provincial-level forest fire data during 1998–2017, this study adopts principal component analysis, clustering analysis, and the information diffusion theory to estimate the temporal-spatial distribution and risk of forest fires in China. Viewed from temporality, China’s forest fires reveal a trend of increasing first and then decreasing. Viewed from spatiality, provinces characterized by high population density and high coverage density are seriously affected, while eastern coastal provinces with strong fire management capabilities or western provinces with a low forest coverage rate are slightly affected. Through the principal component analysis, Hunan (1.33), Guizhou (0.74), Guangxi (0.51), Heilongjiang (0.48), and Zhejiang (0.46) are found to rank in the top five for the severity of forest fires. Further, Hunan (1089), Guizhou (659), and Guanxi (416) are the top three in the expected number of general forest fires, Fujian (4.70), Inner Mongolia (4.60), and Heilongjiang (3.73) are the top three in the expected number of large forest fires, and Heilongjiang (59,290), Inner Mongolia (20,665), and Hunan (5816) are the top three in the expected area of the burnt forest.
Sustainable Consumption Using the Example of Food Processing in a Restaurant
Authors: Gričar Sergej , Šugar Violeta
Published: December 2021

While strategy is of great importance in the hospitality industry, this article is in regard to the process. Therefore, for the first time, this article examines how stuffed yellow peppers are frozen (congelé) and later served as a portion of hot food in restaurants. A sensory analysis was performed, and tasters were invited. Data were collected over three different periods that represented the duration of freezing. The results of the descriptive statistical analysis indicated that the evaluated frozen dishes exhibited degrees of sensory deterioration. The findings are critical to the restaurant business because recipes are often skipped, and the process depends solely on the chefs. The primary value added for management is that strict recipes could improve the cost and shelf life of meals prepared and then frozen in the restaurant by lowering the storage temperature or shortening the freezing time. Incidentally, such analysis should be a continuous development to reduce energy consumption and increase food quality. The consistent results first demonstrated a decreased mouthfeel of the sauce after the first month and, second, a higher stickiness after two months of freezing. In addition, the nutritional values of the dish were calculated using trademarked software.
Life Cycle Assessment of Biocement: An Emerging Sustainable Solution?
Authors: Porter Hannah , Mukherjee Abhijit , Tuladhar Rabin , Dhami Navdeep Kaur
Published: December 2021

Microbially Induced Calcium Carbonate Precipitation (MICP) is a natural biocementation that takes place in corals, stromatolites and beach rocks. In recent years, researchers have explored the emulation of this process as a sustainable alternative of engineered cement. Although the natural process is undoubtedly sustainable, its engineered variant deviates substantially from the natural process. In this paper, we investigate the environmental and economic performance of the engineered biocementation process vis-à-vis present manufacturing of calcium carbonate. SimaPro 8.0 software and the Ecoinvent V2.2 database were used for materials inputs and AUSLCI along with Cumulative Energy Demand 2.01 software were used for carbon footprint and eutrophication potential. Our results show that different metabolic pathways of MICP have considerably varying environmental impact. We observe that nature performs MICP sustainably at ambient conditions and geological time scales utilizing naturally occurring sources of carbon and calcium at micromoles concentrations. Due to the mandate on duration of construction projects, highly purified reactants in a high concentration are used in the engineered process. This has a negative environmental impact. We conclude that the sustainability of engineered MICP is directly impacted by the metabolic pathway of bacteria as well as the purity of the input chemicals. A few biotic processes are superior to the present industrial process for manufacturing calcium carbonate if ingredients of laboratory grade purity are replaced by industrial grade products. A bigger dividend can be obtained by introducing industry by-products as nutrients. The results of this study help to direct future research for developing sustainable biocement for the construction industry.
Sustainability Performance Evaluation of Faceshield Bracket Manufacturing by Using the Analytic Hierarchy Process
Authors: Taddese Getasew , Durieux Severine , Duc Emmanuel
Published: December 2021

Faceshield brackets were among highly relevant products manufactured in various workshops, including Sigma Clermont, during the outbreak of COVID-19 to tackle acute shortages of personal protective equipment. However, many of these products are yet to be checked for appropriateness in design, quality, safety, comfort, and overall sustainability performance which might lead to unknown damages to human health and the environment. Thus, the main objective of this study is to evaluate the sustainable performance of Faceshield bracket manufacturing. Appropriate data are collected from designers, machine operators, and supplementary data are utilized from experts’ opinions and literature. A total of 38 carefully selected indicator sets are utilized while applying multicriteria decision-making methodology (MCDM) of the analytic hierarchy process (AHP) to evaluate the sustainability performance of these manufacturing processes. Evaluation is performed to examine the processes’ sustainability performance and associated indicator contribution based on the three dimensions. Results disclosed that 3D printing (score = 0.108) showed better performance for the environment, and injection molding showed better economic and social performance, with scores of 0.1922 and 0.160, respectively. A detailed contribution of each subcriteria for each sustainability dimension and each of the three processes as well as major contributing indicators are identified and discussed. Finally, overall performance was assessed using the total sum approach, and Borda count methodology and injection molding showed better sustainability performance in the manufacturing of Faceshield brackets considered with scores of 43 and 87, respectively. The authors believe that indicator selection approaches and overall methodology followed for this study will be relevant for future sustainability evaluation of engineering products.
Chlorophylls Extraction from Spinach Leaves Using Aqueous Solutions of Surface-Active Ionic Liquids
Authors: Ferreira Ana M. , Leite Ana Cláudia , Coutinho João A. P. , Freire Mara G.
Published: December 2021

Chlorophylls and their derivatives have been extensively studied due to their unique and valuable properties, including their anti-mutagenic and anti-carcinogenic features. Nevertheless, high-purity-level chlorophylls extracted from natural sources are quite expensive because the methods used for their extraction have low selectivity and result in low yields. This study aimed to develop a “greener” and cost-effective technology for the extraction of chlorophylls from biomass using aqueous solutions of ionic liquids (ILs). Several aqueous solutions of ILs, with hydrotropic and surface-active effects were evaluated, demonstrating that aqueous solutions of surface-active ILs are enhanced solvents for the extraction of chlorophylls from spinach leaves. Operating conditions, such as the IL concentration and solid–liquid ratio, were optimized by a response surface methodology. Outstanding extraction yields (0.104 and 0.022 wt.% for chlorophyll a and b, respectively, obtained simultaneously) and selectivity (chlorophyll a/b ratio of 4.79) were obtained with aqueous solutions of hexadecylpyridinium chloride ([C16py]Cl) at moderate conditions of temperature and time. These extraction yields are similar to those obtained with pure ethanol. However, the chlorophyll a/b ratio achieved with the IL aqueous solution is higher than with pure ethanol (3.92), reinforcing the higher selectivity afforded by IL aqueous solutions as viable replacements to volatile organic compounds and allowing the obtainment of more pure compounds. Finally, the recovery and reuse of the solvent were evaluated by using a back-extraction step of chlorophylls using ethyl acetate. The results disclosed here bring new perspectives into the design of new approaches for the selective extraction of chlorophylls from biomass using aqueous solutions of surface-active ILs.
Toxicity Assessment of a Single Dose of Poly(ethylene glycol) Diglycidyl Ether (PEGDE) Administered Subcutaneously in Mice
Authors: Kim Do-Hyun , Han Jong-Hyeon , Kwon Hyuk-Cheol , Lim Su-Jin , Han Seo-Gu , Jung Hyun-Su , Lee Keyong-Ho , Kang Ju-Hee , Han Sung-Gu
Published: December 2021

Poly(ethylene glycol) diglycidyl ether (PEGDE) is widely used to cross-link polymers, particularly in the pharmaceutical and biomaterial sectors. However, the subcutaneous toxicity of PEGDE has not yet been assessed. PEGDE samples (500–40,000 μg/mouse) were subcutaneously injected into the paraspinal dorsum of BALB/c male mice. Cage-side observations were carried out with measurement of organ weight, body weight variation, and feed intake, as well as histopathological characterization on day 28 post-exposure. Mice that received 40,000 μg of PEGDE showed severe toxic response and had to be euthanized. Subcutaneous injection of PEGDE did not alter feed intake and organ weight; however, the body weight variation of mice injected with 20,000 μg of PEGDE was significantly lower than that of the other groups. Exposure to 10,000 and 20,000 μg of PEGDE induced epidermal ulcer formation and hair loss. The histology of skin tissue in mice administered with 20,000 μg of PEGDE showed re-epithelialized or unhealed wounds. However, the liver, spleen, and kidneys were histologically normal. Collectively, PEGDE, particularly above 10,000 μg/mouse, caused subcutaneous toxicity with ulceration, but no toxicity in the other organs. These results may indicate the optimal concentration of subcutaneously injected PEGDE.
A Questionnaire Study on the Use of Complementary and Alternative Veterinary Medicine for Dogs in Sweden
Authors: Sohlberg Lisa , Bergh Anna , Sternberg-Lewerin Susanna
Published: December 2021

Complementary and alternative veterinary medicine (CAVM) includes treatment methods that are not part of established veterinary medicine and where there is not as yet sufficient scientific documentation of the proposed effects. The CAVM use in Swedish dogs is largely unknown, and the aim of this study was to explore this use. Electronic questionnaires were distributed to dog owners, small animal veterinary practitioners, and CAVM therapists. A total of 253 dog owners responded. Except for massage, stretching, and laser therapy, more than 75% of the respondents stated that they did not use CAVM for their dogs. Of the 216 responding veterinarians, 39% did not use CAVM. CAVM use was more common among respondents with <10 years of work experience as compared to those with >10 years of work experience (p < 0.05). Almost half of the 124 responding CAVM therapists treated dogs; the most frequently used methods included massage, stretching, and acupressure. A majority of all respondents found the current Swedish regulation of CAVM insufficient. Although CAVM use in Swedish dogs appears to be uncommon, there is a need for scientific assessment of CAVM in dogs as regards safety and effectiveness for different indications.