bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunological Effects and Viral Gene Expression Determine the Efficacy of Oncolytic Measles Vaccines Encoding IL-12 or IL-15 Agonists
Authors: Backhaus Paul S. , Veinalde Rūta , Hartmann Laura , Dunder Jessica E. , Jeworowski Lara M. , Albert Jessica , Hoyler Birgit , Poth Tanja , Jäger Dirk , Ungerechts Guy , Engeland Christine E.
Published: October 2019

Tumor-targeted immunomodulation using oncolytic viral vectors is currently being investigated as a promising strategy in cancer therapy. In a previous study, we showed that a measles virus Schwarz vaccine strain (MeVac) vector encoding an interleukin-12 fusion protein (FmIL-12) is an effective immunotherapy in the MC38cea murine colon adenocarcinoma model. We hypothesized that MeVac encoding interleukin-15 may mediate enhanced T and NK cell responses and thus increase the therapeutic efficacy, especially in NK cell-controlled tumors. Therefore, we generated MeVac vectors encoding an interleukin-15 superagonist, FmIL-15. Replication and oncolytic capacity, transgene expression, and functionality of MeVac FmIL-15 vectors were validated in vitro. Effects on the tumor immune landscape and therapeutic efficacy of both FmIL-12 and FmIL-15 vectors were studied in the MC38cea and B16hCD46 tumor models. Treatment with MeVac FmIL-15 increased T and NK cell infiltration in both models. However, MeVac FmIL-12 showed more robust viral gene expression and immune activation, resulting in superior anti-tumor efficacy. Based on these results, MeVac encoding a human IL-12 fusion protein was developed for future clinical translation.
Integrated Assessment of Climate Change and Land Use Change Impacts on Hydrology in the Kathmandu Valley Watershed, Central Nepal
Authors: Lamichhane Suraj , Shakya Narendra Man
Published: October 2019

The population growth and urbanization are rapidly increasing in both central and peripheral areas of the Kathmandu Valley (KV) watershed. Land use/cover (LULC) change and climate variability/change are exacerbating the hydrological cycle in the KV. This study aims to evaluate the extent of changes in hydrology due to changes in climate, LULC and integrated change considering both factors, with KV watershed in central Nepal as a case study. Historical LULC data were extracted from satellite image and future LULC are projected in decadal scale (2020 to 2050) using CLUE-S (the Conversion of Land Use and its Effects at Small regional contest) model. Future climate is projected based on three regional climate models (RCMs) and two representative concentration pathways (RCPs) scenarios, namely, RCP4.5 and RCP8.5. A hydrological model in soil and water assessment tool (SWAT) was developed to simulate hydrology and analyze impacts in hydrology under various scenarios. The modeling results show that the river runoff for RCP4.5 scenarios is projected to increase by 37%, 21%, and 12%, respectively, for climate change only, LULC only, and integrated changes of both. LULC change resulted in an increase in average annual flow, however, a decrease in base-flow. Furthermore, the impacts of integrated changes in both LULC and climate is not a simple superposition of individual changes.
JAMINANAN PINJAMAN POLIS DALAM PERJANJIAN KREDIT ( STUDI AJB BUMIPUTERA 1912)
Authors: Fauziah Fauziah
Published: October 2019

Dalam  perkembangannya jaminan pinjaman polis bukan lagi berfungsi sebagai sarana pemasaran polis saja, akan tetapi sudah merupakan sumber investasi bagi perusahaan asuransi dengan menerapkan bunga yang cukup tinggi yang didapatkan dari setiap kredit dengan jaminan pinjaman polis tersebut.

            Bersamaan dengan berkembangnya kredit dengan jaminan pinjaman polis pada setiap perusahaan asuransi, maka bersamaan itu pula pelaksanaanya haruslah dilakukan dengan regulasi yang jelas serta memerlukan penanganan yang baik dan serius bagi setiap perusahaan asuransi, hingga hasilnya dapatlah dirasakan saling menguntungkan bagi kedua belah pihak, baik itu pemberi jaminan pinjaman polis/nasabah asuransi maupun pemegang jaminan pinjaman polis/ perusahaan asuransi, dengan tetap berpegang kepada keadilan, kepastian hokum dan kebahagiaan.
DETERMINATION OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS ADULTERATED IN HERBAL MEDICINES BY LC-MS/MS
Authors: Dao Thi Cam Minh , Thai Khoa Bao Chau , Tran Huu Dung , Pham Thi Thanh Ha , Nguyen Thi Kieu Anh
Published: October 2019

Background: Nonsteroidal anti-inflammatory drugs commonly adulterated in herbal medicines, especially in products used in the treatment and supportive treatment of osteoarthritis, have caused a lot of toxicities, catastrophes for the sick.

Objectives: Determination paracetamol, piroxicam, indomethacin and ketoprofen adultered in herbal medicines by LC-MS/MS; applied methods in real herbal preparations.

Materials and methods: Blank matrix is based on a traditional remedy (Vietnam Pharmacopeia IV). The analytical method is developed and validated in accordance with AOAC and ICH guidelines.

Results: The simple and rapid extraction method gives high extraction efficiency (over 85%). LC-MS condition using Electrospray Ionization technique with positive mode separated 4 substances clearly with good peak shapes and relatively short retention time, a low detection limit (0.076-0.5ng/ml), correlation coefficients r> 0.995; Repeatability meets AOAC requirements.

Conclusions: Developed a method for the simultaneous analysis of paracetamol, piroxicam, indomethacin, and ketoprofen that can be mixed illegally in herbal medicines. Detected 3 positive samples with paracetamol, indomethacin in herbal medicinal products on the market.

Key words: Paracetamol, piroxicam, indomethacin, ketoprofen, herbal medicines, LC-MS/MS
THE ROLE OF POLYETHYLENIMINE IN ENHANCING PERFORMANCE OF GLUTAMATE BIOSENSORS
Authors: Do Thi Hong Diep , Le Phuoc Duong , Nguyen Thi Hoai , Pier Andrea Serra , Gaia Rocchitta
Published: October 2019

Background: The first biosensor was constructed more than fifty years ago. It was composed of the biorecognition element and transducer. The first-generation enzyme biosensors play important role in monitoring neurotransmitter and determine small quantities of substances in complex matrices of the samples Glutamate is important biochemicals involved in energetic metabolism and neurotransmission. Therefore, biosensors requires the development a new approach exhibiting high sensibility, good reproducibility and longterm stability. The first-generation enzyme biosensors play important role in monitoring neurotransmitter and determine small quantities of substances in complex matrices of the samples. The aims of this work: To find out which concentration of polyethylenimine (PEI) exhibiting the most high sensibility, good reproducibility and long-term stability.

Methods: We designed and developed glutamate biosensor using different concentration of PEI ranging from 0% to 5% at Day 1 and Day 8.

Results: After Glutamate biosensors in-vitro characterization, several PEI concentrations, ranging from 0.5% to 1% seem to be the best in terms of VMAX, the KM; while PEI content ranging from 0.5% to 1% resulted stable, PEI 1% displayed an excellent stability.

Conclusions: In the result, PEI 1% perfomed high sensibility, good stability and blocking interference. Furthermore, we expect to develop and characterize an implantable biosensor capable of detecting glutamate, glucose in vivo.

Key words: Glutamate biosensors, PEi (Polyethylenimine) enhances glutamate oxidase, glutamate oxidase biosensors
Mobile Internet Usage Possibilities and Requirement in Agriculture
Authors: Szilágyi Róbert
Published: October 2019

In this paper, I looked at the mobile Internet from technological, economical and sociological aspects and then pointed to several agricultural possibilities for theri usage. Examining the effects and driving forces of mobile communication, I can say that it is a very complex system. The social connections of mobile communication and the arising problems show that it affects several areas of everyday life. By looking at the business processes, all costs, advantages and disadvantages can be seen clearly. Overview the mobile Internet from the technological aspect and I discuss related technology and applicable utilities, as well as two possibilities for using wireless Internet: 3G and WiFi. Among the possible usages, I gave several examples to give an impression of all the diverse possibilities this technology offers. There are some really useful applications in customer service, precision farming, transport, agriculture and food industry. Finally, I talked about the mobile Internet in Hungary and in the other EU countries.
’The sweet fruition of an earthly crown’: Elemental mastery and ecophobia in Tamburlaine the Great and Doctor Faustus
Authors: Yılmaz Zümre Gizem
Published: October 2019

Although the elements have been exploited for human ends in early modern discursive practices, they have so saturated social and cultural life that writers of the period could not avoid mentioning elemental formations. Marlowe’s Tamburlaine, Part I and Part II (1587) and Doctor Faustus (1592) are significant representatives of early modern English drama that highlight the inter-relationships between the human body and the elements. This study examines elemental agency, to show how the agential capacity of the four classical elements unveils ecophobic treatment; and how the ecophobic strain in the human psyche is reflected in Christopher Marlowe’s Tamburlaine and Doctor Faustus.
“The gully-hole of literature”: On the enregisterment of cant language in seventeenth-century England.
Authors: Schintu Paula
Published: October 2019

This essay places seventeenth-century literary renditions of cant, the language spoken by rogues and criminals in Early Modern England, into the context of “enregisterment” so as to examine its role in the process of recognition, categorization and legitimation of the canting tongue and the values it entailed. Literary representations of this variety became common in the period under analysis as a result of the criminal element that threatened the English population. Drama emerged as one of the main vehicles for the representation of cant, leading to the appearance of numerous plays that dealt with the life and adventures of English rogues. In the pages that follow, it will be argued that the study of these textual artefacts can provide valuable historical insight into the use of cant and the social connotations associated with it. In fact, the corpus-based analysis of the plays selected for this study has made it possible to identify both a common lexical repertoire and a set of sociocultural features that were associated with this underworld variety and its wicked speakers by the London non-canting audience. At the same time, it has shed light on the processes whereby this encoded speech came to index derogatory cultural values, which were spread and consumed thanks, in part, to dramatic performance, leading to the enregisterment of cant language and its recognition as a stable and unique linguistic variety.
SCIENTIFIC TASKS OF INNOVATION
Authors: Andreev Yu.N.
Published: October 2019

The article analyzes the subject of innovation as an independent scientific direction, which has its own subject of research. It is shown that in scientific literature on innovation, including monographs and textbooks, there is no distinction between traditionally economic problems and problems of innovation activity. At the same time, opposite processes are taking place: private issues of economics are included in innovation, but the concepts of political economy, which form the basis of the methodology of economics, are not used. As a result, questions that constitute the core of the theoretical problems of innovation remain outside the scope of attention. The general picture of ideas about the subject of innovation in scientific publications is shown. Opinions are expressed on the features of research methods of innovation. Some scientific and practical problems are presented, which should be responded by innovation.
PUBLIC EXAMINATION OF THE IMPLEMENTATION OF EDUCATIONAL PROGRAMS: EXPERIENCE AND RESULTS
Authors: Sablukov A.V.
Published: October 2019

The article presents the methodology of sociological monitoring of the educational programs implementation, developed by a group of researchers of the Sociology Department of the Moscow State Linguistic University, and the results of the public examination of the program for the development of education in Moscow, based on this methodology. The assessment was based on system of indicators, which was developed mainly in view of of the key indicators of the «Capital Education» program for both the program as a whole and its individual parts (subprograms). According to the researchers, the method can be recommended in full or in part to conduct public examination of educational programs at various levels.
DETERMINANTS AND MITIGATION FACTORS OF TAX EVATION : INDONESIA EVIDENCE
Authors: Agus Yolisia Framita , Umiyati Indah , Kurniawan Asep
Published: October 2019

This study aims to determine the effect of justice, system, understanding, tax rates and sanctions on tax evasion. The method used in this study is descriptive quantitative by using primary data. The technique of collecting data with a questionnaire distributed to corporate taxpayers registered at Pratama KPP with a sample of 110 respondents. Data analysis in this study is multiple regression with SPSS version 22 program.

The results of this study indicate that understanding taxation affects tax evasion. While justice, system, tax rates and sanctions have no effect on tax evasion.
INTELLECTUAL INTELLIGENCE, LEARNING BEHAVIOR AND AVAILABILITY OF EDUCATIONAL MEANS ON INTERMEDIATE ACCOUNTING UNDERSTANDING WITH MOTIVATION AS A MODERATING VARIABLE
Authors: Nuraini Fitri
Published: October 2019

Abstract

Intermediate Financial Accounting is a continuation of accounting science from basic accounting, the countain in intermediate financial accounting includes riil account accounting treatment and special accounting problems. Concepts in intermediate financial accounting explain accounting treatment including recognition, measurement, statement and disclosure. This study examines the influence of intellectual intelligence, accounting behavior and availability of educational facilities on the understanding of intermediate financial accounting with motivation as a moderating variable.

The sampling technique used convenience sampling with a sampling of 43 students. The study uses the Moderated Regression Analysis (MRA) analysis tool.

The results showed that (1) intellectual intelligence, learning behavior and the availability of educational facilities had no significant effect on the understanding of intermediate financial accounting, (2) motivation to moderate the influence of intellectual intelligence and learning behavior on understanding middle financial accounting, (3) motivation does not moderate the influence of availability educational facilities for understanding middle financial accounting.
Mengonstruksi Rancangan Soal Domain Kompetensi Literasi Saintifik Siswa SMP Kelas VIII pada Topik Gerak Lurus
Authors: Setiawan Adib Rifqi
Published: October 2019

Seiring perkembangan zaman, literasi saintifik dipilih sebagai tujuan utama pendidikan sains. Literasi saintifik dianggap bisa digunakan untuk mempersiapkan generasi saat ini untuk menghadapi saat nanti. Literasi saintifik adalah pemahaman terhadap konsep dan proses sains serta bisa menggunakan pemahaman tersebut dalam keseharian. Sebagai tujuan utama dalam pendidikan sains, literasi saintifik dalam keseharian masyarakat menjadi gambaran keberhasilan pendidikan sains yang dilakukan oleh setiap negara. Namun kemampuan ini belum dilatihkan secara optimal melalui proses pembelajaran sains di Indonesia. Peneliti melakukan konstruksi soal yang bisa digunakan untuk mengukur kemampuan literasi saintifik siswa dalam domain kompetensi pada topik gerak lurus. Penelitian ini menggunakan penelitian deskriptif jenis survei dengan jumlah soal 18 butir. Populasi dalam penelitian ini adalah siswa kelas VIII di salah satu SMP Negeri di Kabupaten Bandung Barat dengan jumlah sampel sebanyak 140 orang siswa kelas VIII menggunakan pengambilan sampel acak. Dari hasil penelitian diperoleh koefisien reliabilitas (rhh) sebesar 0,73 (kategori tinggi) dengan validitas item, tingkat kesukaran, dan daya pembeda setiap butir soal yang beragam. Hasil yang diperoleh akan dijadikan acuan untuk menganalisis kesulitan literasi saintifik siswa SMP kelas VIII pada topik gerak lurus serta merekonstruksi rencana pembelajaran sains yang melatihkan literasi saintifik.
INTELLIGENT ROOFTOP GREENHOUSES AND GREEN SKYLINE CITIES
Authors: Balas Marius , Nikolic Jelena , Lile Ramona , Popa Mihaela , Beiu Roxana
Published: October 2019

The paper proposes a new concept of green building, able to oppose the global warming, the Intelligent Rooftop Greenhouse iRTG, as a development of the Integrated Rooftop Greenhouse IRTG. Our approach is to re­place conventional roofs with IRTGs, which are constructively con­nected with the interior of the building by flows of energy, gazes (mainly O2 enriched air from RTG to building and CO2 enriched air from build­ing to RTG) and water in order to improve the building’s metabolism. A tight human-plant sym­biosis is created such way. iRTGs perfect this architecture by actively controlling the energy, gazes and water flows, by collecting the available renewable energy resources (geothermal, sun, wind) and by adding Internet of Things IOT features to the system, in order to connect it to a surrounding Smart City. This way iRTGs may achieve an efficient integrated management of energy, gases and water, using just existing technologies: heat pumps (water to water for building’s basement and air to air for green­house), solar panels, IOT equipment, etc., controlled in a smart/intelligent manner. If a Smart City is composed mostly of iRTG buildings it becomes a Smart Green Skyline City, with low carbon foot­print and high carbon offset. The paper provides a mathematical iRTG model.
THE EFFECT OF MICROFRACTURING IN GABBRO-DOLERITES ON THEIR PHYSICAL PROPERTIES
Authors: Shekov Vitali , Myasnikova O.
Published: October 2019

Simple and cheap methods for the study of building stone deposits for the production of blocks of commercial size can be used to make geological work more efficient. However, physical processes in a massif are hard to understand when doing geophysical research, and the effect of microstructural parameters, mainly the microfracturing of rocks, on geophysical field indices is poorly understood.

The authors have studied the impact of microfracturing on the physico-mechanical properties on coarse- to giant-grained rapakivi granites from the Salmi massif, Fennoscandian Shield. The goal of the present study is to assess the physical and physico-mechanical parameters in fine- and medium-grained quartz-free rocks.

The authors have studied the various physical and physico-mechanical indices of gabbro-dolerites from the Ropruchei sill (Fennoscandian Shield, within the deposit prospected and revealed the effect of microfracturing indices on them.

The study of these properties have shown that microfracturing in gabbro-dolerites is an essential factor which forms the physical parameters of a rock. The testing of this rock type has shown the rate of travel of an elastic wave is clearly related to the microfracturing of samples.

The magnetic properties of gabbro-dolerite are due to high concentrations of titanomagnetite, the mineral grains of which formed upon the crystallization of magma during its interstratal intrusion. The distribution of titanomagnetite, based on size and concentration in the rock, depends on liquation conditions in the active stress field. The dependence of the microfracturing of gabbro-dolerites on their iron concentration (FeO+Fe2O3) shows that these «damages» appeared at a ‘brittle” stage in the evolution of the massif in the form of microfractures, the structural parameters of which have inherited the parameters of the stress and deformation field which existed in the massif at that time and which accumulated iron.

As a result, microfracturing has a considerable effect on the parameters of the electromagnetic indices of the massif by accumulating iron oxides in the pores, and the higher the index, the higher the geophysical medium indices.

Understanding of the physical problem, which accompanies the formation of a gabbro-dolerite complex, helps conduct the geophysical study of a massif, interpret data more objectively and more accurately delineate massive zones in the medium that could be used as high-quality building materials.
PEMBUKTIAN DALAM TINDAK PIDANA PEMBUNUHAN BERENCANA DITINJAU DARI KITAB UDANG-UNDANG HUKUM PIDANA
Authors: Pieter Salvadoris , Silambi Erni Dwita
Published: October 2019

Pembunuhan berencana diatur dalam Pasal 340 Kitab Undang-Undang Hukum Pidana (KUHP). Dalam pasal ini unsur dengan direncanakan terlebih dahulu menjadi perdebatan, apakah unsur tesebut perlu menggunakan motif untuk membuktikannya atau hanya dengan jarak waktu dimana pelaku dapat berpikir tenang untuk melakukan atau tidak melakukan rencananya atau dengan kata lain terjadi kekaburan norma dalam pasal ini. Tujuan dalam penilitian ini untuk mencari dan menggali apa yang dimaksud dengan unsur perencanaan dan bagaimana cara membuktikannya serta bagaimana pertimbangan hakim dalam menjatuhkan pidana terhadap palaku pembunuhan berencana. Sehingga untuk menjawab kekaburan norma tersebut diatas jenis penelitian yang dilakukan oleh penulis adalah penelitian yuridis normatif dengan menggunakan pendekatan statute approach (pendekatan perundang-undangan) dan case approach (pendekatan kasus). Hasil penelitian bahwa terjadi kekaburan norma didalam Pasal 340 kitab undang-undang hukum pidana terutama pada unsur â€œDengan Rencana Terlebih Dahuluâ€ dalam Pasal 340 KUHP. Selain itu hasil penelitian ini juga memberikan pemahaman bahwa pertimbangan hakim dalam menjatuhkan pidana terhadap pelaku tindak pidana pembunuhan berencana harus berdasarkan Pasal 183 KUHAP yaitu harus 2 (dua) alat bukti (Pasal 184 KUHAP) yang sah serta ditambah dengan kayakinan hakim terhadap pelaku pembunuhan berencana atau sesuai dengan teori undang-undang negatif. Alat bukti yang paling menujang untuk membuktikan tindak pidana pembunuhan berencana adalah alat bukti keterangan saksi, surat dan petunjuk. Dalam penjatuhan pidana bagi pelaku tindak pidana pembunuhan berencana oleh hakim, pertimbangan hakim berdasarkan pertimbangan secara yuridis dan sosiologis.
PRICE-SETTING PRACTICES FOR NEW PRODUCT INTRODUCTIONS: EVIDENCE FROM BULGARIA
Authors: Marinov Krasimir
Published: October 2019

This paper presents the importance of the price-setting practices in the Bulgarian companies. According to the published research, the pricing, including that for the new products at their introduction into the market, is one of the most complex decisions in the company. When setting the price for a new product, the companies apply three price-setting practices: value-based pricing, competition-based pricing, and cost-based pricing. Results of empirical study amongst Bulgarian companies reveal that the most important price-setting factor for the tangible products are the prices of competitors’ products, and for the services - the fit between price and product parameters.
PROPUESTA CURRICULAR PARA LA FORMACIÓN DE MÉDICOS INTERNISTAS EN COLOMBIA
Authors: Pinilla Roa Análida Elizabeth
Published: October 2019

Esta propuesta curricular, construida durante las dos últimas décadas, va más allá de las dificultades causadas por la normatividad en salud en Colombia. La convicción de un internista es comprender su identidad deontológica (“deontos”: “deberes”), la razón de ser de un internista, su deber y compromiso con un paciente, la familia, la sociedad y la nación; esta identidad del internista armoniza diversas competencias profesionales para brindar cuidado y atención al paciente y su familia. En este sentido, la universidad tiene la responsabilidad de planear y realizar la formación integral desde el pregrado, pero, más aun, en la formación de posgrado en la especialidad de medicina interna, con un enfoque renovado de currículo apoyado en el aprendizaje y el desarrollo de competencias profesionales por los médicos residentes.

Se busca aportar un soporte educativo y pedagógico para comprender, apropiar e implementar conceptos complejos como aprendizaje, currículo, competencias en educación, competencias profesionales, didáctica, enseñanza, evaluación; es prioritario que los directivos y los profesores de medicina interna se conciencien de la necesidad de avanzar hacia la creación de un currículo para formar internistas, que supere los planes de estudio y los programas de esta especialidad.

Se plantean algunos requisitos para un currículo socioconstructivista en medicina interna: pedagógicos, de los docentes, universidades y asociaciones, los cuales están centrados en la competencias profesionales que debe desarrollar un médico residente durante su formación como internista (específicas nucleares y clínicas; transversales emergentes). Además, se dan los lineamientos de un plan de estudios engranado en este tipo de currículo, el impacto social y el campo de acción actual del egresado.

Así, esta propuesta curricular incluye un perfil de competencias profesionales para un internista en Colombia que responde a las expectativas de un paciente, la normatividad vigente en la sociedad colombiana y las exigencias de la globalización; por tanto, urge una reforma curricular, con el compromiso de docentes y directivos; entonces, se invita a ir más allá de los planes de estudio de rotaciones a un currículo con fundamentación social, humanística, pedagógica y política acorde al contexto.
REGURGITACION MITRAL FUNCIONAL SEVERA. MANEJO PERCUTÁNEO CON CLIP MITRAL, UNA OPCION SEGURA PARA PACIENTES QUE NO PUEDEN SER LLEVADOS A CIRUGIA
Authors: Senior Juan Manuel
Published: October 2019

La regurgitación mitral funcional (RMF) es una complicación frecuente en pacientes que cursan con una falla cardiaca dilatada, se desarrolla como consecuencia de la remodelación y crecimiento de cavidades que lleva a un incremento de las fuerzas que traccionan el aparato valvular mitral causando su mal funcionamiento.

La RMF es una causa conocida de disnea, deterioro funcional, isquemia miocárdica y de disfunción ventricular, a pesar de la terapia medica disponible, causa de deterioro de la calidad de vida de los pacientes y de ingresos frecuentes a los servicios de urgencias por descompensaciones. Reportamos un caso de RMF con riesgo alto para cirugía correctiva, con deterioro de su calidad de vida, llevada a implante de clip mitral de forma exitosa y sin complicaciones.
CHRONIC KIDNEY DISEASE
Authors: Editorial Article
Published: October 2019

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SISTEM INFORMASI MANAJEMEN DATA PENDUDUK DI KANTOR DESA HATEBICARA KABUPATEN HALMAHERA BARAT
Authors: Marasabessy Nadia Arizha , Sangaji Sabria , . Muharto , Nurdiyani Yuslinah
Published: October 2019

Kantor Desa Hatebicara terletak di Halmahera Barat Provinsi Maluku Utara, tepatnya di jln. Ki hajar dewantara, Desa Hatebicara, Halmahera Barat. Sistem informasi pendataan penduduk menggunakan metode prototyping berbasis web pada kantor desa Hate bicara Halmahera Barat membuat sistem pengolahan data penduduk dengan cepat dan akurat. Metode analisis sistem menggunakan metode analisis terstruktur, serta pengembangannya menggunakan metode Prototype, sistem ini dirancang dengan Flowchart, DFD (data flow diagram), ERD (entity relationship diagram) dan dibuat menggunakan bahasa pemrograman HTML, CSS, PHP, Jquery, Javascript serta Database MySQL, dengan adanya aplikasi sistem informasi pendataan penduduk diharapkan kegiatan dalam pengolahan data kependudukan bisa jadi lebih efektif dan efisien, sehingga hasil laporan data penduduk tidak terjadi kesalahan dan mempermudah petugas kantor desa dalam mengolah data kependudukan.
Excited state dynamics for visible-light sensitization of a photochromic benzil-subsituted phenoxyl-imidazolyl radical complex
Authors: Kobayashi Yoichi , Mamiya Yukie , Mutoh Katsuya , Sotome Hikaru , Koga Masafumi , Miyasaka Hiroshi , Abe Jiro
Published: October 2019

Visible-light sensitized photoswitches have been paid particular attention in the fields of life sciences and materials science because long-wavelength light reduces photodegradation, transmits deep inside of matters, and achieves the selective excitation in condensed systems. Among various photoswitch molecules, the phenoxyl-imidazolyl radical complex (PIC) is a recently developed thermally reversible photochromic molecule whose thermal back reaction can be tuned from tens of nanoseconds to tens of seconds by rational design of the molecular structure. While the wide range of tunability of the switching speed of PIC opened up various potential applications, no photosensitivity to visible light limits its applications. In this study, we synthesized a visible-light sensitized PIC derivative conjugated with a benzil unit. Femtosecond transient absorption spectroscopy revealed that the benzil unit acts as a singlet photosensitizer for PIC by the Dexter-type energy transfer. Visible-light sensitized photochromic reactions of PIC are important for expanding the versatility of potential applications to life sciences and materials science.
CHARACTERIZATIONS ON FRACTURE PROCESS ZONE OF PLAIN CONCRETE
Authors: Tang Yuxiang , Chen Hongniao
Published: October 2019

The fracture property of concrete is essential for the safety and durability analysis of concrete structures. Investigating the characteristics of the fracture process zone (FPZ) is of great significance to clarify the nonlinear fracture behaviour of concrete. Experimental and numerical investigations on the FPZ of plain concrete in pre-notched beams subjected to three-point bending were carried out. Electronic speckle pattern interferometry (ESPI) technique was used to observe crack evolution and measure the full-field deformation of the beams. The development of the FPZ were evaluated qualitatively and quantitatively based on the in-plane strain contours and displacement field measured by ESPI, respectively. By integrating the cohesive crack model and finite element (FE) model, various tension softening curves (TSCs) were employed to simulate the fracture response of concrete beams. By comparing the deformation obtained by FE simulation and experiments, the TSCs of plain concrete were evaluated and most suitable TSCs of concrete were recommended.
Searches for Interstellar HCCSH and H2CCS
Authors: McGuire Brett A. , Shingledecker Christopher N. , Willis Eric R. , Kelvin Lee Kin Long , Martin-Drumel Marie-Aline , Blake Geoffrey A. , Brogan Crystal L. , Burkhardt Andrew M. , Caselli Paola , Chuang Ko-Ju , El-Abd Samer , Hunter Todd R. , Ioppolo Sergio , Linnartz Harold , Remijan Anthony J. , Xue Ci , McCarthy Michael C.
Published: October 2019

A longstanding problem in astrochemistry is the inability of many current models to account for missing sulfur content. Many relatively simple species that may be good candidates to sequester sulfur have not been measured experimentally at the high spectral resolution necessary to enable radioastronomical identification. On the basis of new laboratory data, we report searches for the rotational lines in the microwave, millimeter, and submillimeter regions of the sulfur-containing hydrocarbon HCCSH. This simple species would appear to be a promising candidate for detection in space owing to the large dipole moment along its b-inertial axis, and because the bimolecular reaction between two highly abundant astronomical fragments (CCH and SH radicals) may be rapid. An inspection of multiple line surveys from the centimeter to the far-infrared toward a range of sources from dark clouds to high-mass star-forming regions, however, resulted in nondetections. An analogous search for the lowest-energy isomer,

, is presented for comparison, and also resulted in nondetections. Typical upper limits on the abundance of both species relative to hydrogen are 10−9–10−10. We thus conclude that neither isomer is a major reservoir of interstellar sulfur in the range of environments studied. Both species may still be viable candidates for detection in other environments or at higher frequencies, providing laboratory frequencies are available.
Effect of Combined Application of Growth Factors and Diode Laser Bio-Stimulation on the Osseo Integration of Dental Implants
Authors: Arakeeb Mohamed Ali Ali , Zaky Ahmed Abbas , Harhash Tarek Abdel-Hamid , Salem Walid S. , El-Mofty Mohamed
Published: October 2019

BACKGROUND: The success of implants is associated first with their osseointegration, and later on with their survival rate. In recent years, many efforts have been exerted to develop implant design, geometry, materials and techniques to enhance the osseointegration process and also to increase the success rate of implant procedures. New techniques, like leukocyte and platelet-rich fibrin (L-PRF) and low-level laser treatment (LLLT), have been developed to enhance the osseointegration around dental implants.
AIM: This study aims at accelerating bone osseointegration process around dental implant using new techniques to increase the success rate, to allow immediate or early loading of a dental implant, and to make a comparison between the various new techniques in dental implant procedures to figure out which technique will achieve the best results.
METHODS: The study was conducted on a random sample of 40 male patients. Dental implants were placed in the posterior areas of the lower jaw. Patients were divided randomly into 4 groups; control group, LLLT group, L-PRF group and L-PRF plus LLLT group. They were assessed using cone-beam computed tomography (CBCT).
RESULTS: The results showed significant differences between all groups over different measured times. All the groups showed improvement in comparison with Normal group, where L-PRF group showed the best result followed by (L-PRF+LLLT) group, while the LLLT group showed the least improvement in comparison with bothL-PRF group and (L-PRF+LLLT) group.
CONCLUSION: The study demonstrates that L-PRF gives a better performance in the osseointegration around dental implants than LLLT.
Valeur(s) & management
Authors: Jehanin Laurent
Published: October 2019

La relativité du concept de valeur permet de l’utiliser pour les achats de tous les types d’organisation, avec des métriques qui leur sont propres. Lorsqu’il s’agit de l’entreprise, les achats créent de la valeur pour l’entreprise directement en réduisant les coûts, en réduisant la consommation de liquidités, en réduisant le niveau de risque… Mais les achats créent également de la valeur de manière contributive : par la gestion de l’innovation des fournisseurs avec l’effet d’accroître les ventes ou de réduire les coûts, par le soutien des ventes dans un territoire, etc. Par ailleurs, la création de valeur financière par les achats peut se manifester, outre la variation d’un flux, comme le résultat ou le cash-flow, par l’accroissement d’un actif, comme la base fournisseurs, dont la valorisation fait aujourd’hui défaut. Enfin, les achats créent de la valeur pour les parties prenantes de l’entreprise : fournisseurs, clients, salariés, citoyens, territoire, société en général…, ce qui peut ouvrir un potentiel encore plus considérable que les économies à court terme, sans négliger ces dernières.
Villes plurielles : géographie(s) urbaine(s) de la différence
Authors: Margier Antonin , Sepúlveda Bastien
Published: October 2019

Ce numéro de L’Information géographique aborde le concept de différence en tant qu’il participe à la construction des espaces urbains. La différence peut aussi bien être attribuée de façon négative que revendiquée de façon positive. Dans tous les cas elle entraine des usages de l’espace différenciés.
Séparer ou unir ? L’ambivalence de la diversité dans les espaces nocturnes de Beyrouth
Authors: Bonte Marie
Published: October 2019

Reposant sur une enquête qualitative menée entre 2013 et 2016, cet article analyse les espaces de la vie nocturne de Beyrouth au prisme de la différence. À travers la notion de canopée cosmopolite (Anderson 2004), l’article montre comment les établissements que sont les bars et les clubs ainsi que les pratiques et les sociabilités qui s’y rattachent permettent un effacement temporaire des lignes de divisions (confessionnelles, socio-économiques, ethniques, de même que celles liées au genre ou à l’orientation sexuelle) tout en produisant des formes d’entre-soi économique et culturel. Cette dialectique de la canopée nocturne est chevillée aux problématiques de la ville post-conflit. Les espaces nocturnes constituent d’abord une forme d’appropriation de la ville sur un mode festif, ainsi qu’une manière de reconquérir la ville au-delà des divisions imposées par la guerre civile (1975-1990). En fonction des critères observés, la différence constitue par ailleurs un attribut ou un potentiel des lieux nocturnes : elle est expérimentée autant qu’elle est revendiquée. Ce sont donc les discours des noctambules et la mise en scène d’une « ville pacifiée » à travers ses nuits qui seront enfin analysés, afin de montrer que les rapprochements permis par la nuit créent d’autres processus de distinction et de domination.
Le parkour, une pratique au service de la participation juvénile en ville ? Dissidence récréative et affirmation des jeunes à Rennes et à Nantes
Authors: Lesné Robin
Published: October 2019

Le parkour est un ludo-sport investissant les espaces ouverts et cumulant une double différentiation de la société urbaine par ses dimensions subversive et juvénile. Engageant une expérience alternative de l’espace, il invite au renouvellement du rapport à la ville d’un point de vue spatial, par le dépassement de sa division fonctionnelle et la réintroduction de la récréativité, mais également social, les pratiquants revendiquant une place dans le système décisionnel et une démocratie davantage participative. L’analyse du traitement institutionnel de cette pratique démontre que les projets d’aménagement peuvent constituer des outils de ce renouvellement. En mobilisant le concept de dissidence récréative, la déviance devient un élément positif au sein de la diversité urbaine. Ainsi, le parkour contribuerait à l’émergence d’une participation citoyenne renouvelée propre aux jeunes.
A Spreadsheet Template for the Analysis of Optical Coherence Tomography in the Longitudinal Management of Diabetic Macular Edema
Authors: Browning David J. , Fraser Christina M. , Powers Michelle E.
Published: October 2019

BACKGROUND AND OBJECTIVE  To provide a tool for analyzing optical coherence tomography data in patients with diabetic macular edema.  PATIENTS AND METHODS Retrospective series of 206 patients with diabetic macular edema involving at least one eye and receiving focal laser photocoagulation, intravitreal triamcinolone acetonide injection, or vitrectomy, membrane peeling, and intravitreal triamcinolone acetonide injection, and of untreated fellow eyes without diabetic macular edema. Main outcome measures included foveal subfield mean thickness and thickening relative to normal (microns), total macular volume and its increase relative to normal (mm3), visual acuity (Snellen decimal), and intraocular pressure (mm Hg).  RESULTS  The authors demonstrate a graphical display of data based on a spreadsheet template for the longitudinal management of diabetic macular edema. Complex relationships of ocular response and interventions are concisely displayed.  CONCLUSION A graphical display of optical coherence tomography, visual acuity, and intraocular pressure data is a practical aid in the management of diabetic macular edema.  [Ophthalmic Surg Lasers Imaging 2006;37:399-405.]  AUTHORS From Charlotte Eye, Ear, Nose, and Throat Associates, PA, Charlotte, North Carolina.  Accepted for publication June 13, 2006.  Address reprint requests to David J. Browning, MD, PhD, 6035 Fairview Rd., Charlotte, NC 28210. 
Extrafoveal Choroidal Neovascularization Secondary to Wet Age-Related Macular Degeneration Treated With Intravitreal Bevacizumab
Authors: Mones Jordi M. , Lopez Mauricio A. , Prieto Jorge A. , Rodriguez Juan P.
Published: October 2019

Considering the risk of recurrence of extrafoveal or juxtafoveal lesions after thermal laser treatment and the risk of poor response to photodynamic therapy, it seems reasonable to discuss with the patient the risks and benefits of antiangiogenic therapy. A case of age-related macular degeneration with an extrafoveal choroidal neovascularization treated with a single injection of intravitreal bevacizumab is described. The patient showed both anatomic and visual acuity improvement at 1 month following treatment that persisted even at the 8-month follow-up visit. Further studies are needed to validate the real risk-benefit ratio of intravitreal bevacizumab for extrafoveal exudative lesions versus the current treatments available. [Ophthalmic Surg Lasers Imaging 2007;38:226-228.] AUTHORS From the Instituto de Microcirugía Ocular (JMJ, MAL, JAP, JPR); and the Universidad Autónoma de Barcelona (JMJ), Barcelona, Spain. Accepted for publication September 30, 2006. Address correspondence to Mauricio A. Lopez, MD, 10 Munner Strett, Barcelona, 08022, Spain.
Documentation of Optic Nerve Pit With Macular Schisis-like Cavity by Spectral Domain OCT
Authors: Lalwani Geeta A. , Punjabi Omar S. , Flynn Harry W. , Knighton Robert W. , Puliafito Carmen A.
Published: October 2019

The authors report using spectral domain optical
coherence tomography (OCT) to observe a patient with an optic nerve pit and macular schisis-like spaces. An 8-µm axial resolution prototype spectral domain OCT and stereo fundus photography were used to observe
the patient. A macular schisis-like cavity was present
at baseline and additional cystic changes developed in the nerve fiber layer over a period of 16 months; however,
the visual acuity remained stable at 20/20. Spectral domain OCT provides greater detail of the changes in morphology and structure of macular schisis and edema associated with an optic nerve pit. [Ophthalmic Surg Lasers Imaging 2007;38:262-264.] AUTHORS From the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. Accepted for publication December 12, 2006.Supported in part by Research to Prevent Blindness, Inc., New York, New York. Research funding provided in part by a grant from Carl Zeiss Meditec (OSP, GAL, RWK, CAP). Dr. Puliafito is a Research and Clinical Consultant for Carl Zeiss Meditec.Dr. Puliafito did not participate in the editorial review of this manuscript.Address correspondence to Geeta A. Lalwani, MD, 900 NW 17th Street, Miami, FL 33136.
Gender Differences in Function, Physical Activity, Falls, Medication Use, and Life Satisfaction Among Residents in Assisted Living Settings
Authors: Resnick Barbara , Boltz Marie , Galik Elizabeth , Holmes Sarah , Fix Steven , Zhu Shijun
Published: October 2019

The purpose of the current study was to test for gender differences among residents living in assisted living settings. This was a secondary data analysis using data from the first 64 facilities participating in the ongoing Function Focused Care for Assisted Living study using the Evidence Integration Triangle (FFC-AL-EIT). A total of 593 residents were recruited. Differences by gender with regard to function, physical activity, falls, total number of medications, and satisfaction with assisted living were tested using multivariate analysis of variance. There were 166 (28%) men and 427 (72%) women with a mean age of 88 (
SD
= 7.5 years). Participants had five (
SD
= 2) comorbidities and took on average 6.88 medications (
SD
= 3.47). Participants had moderate functional impairment with a mean of 64.13 (
SD
= 19.09) on the Barthel Index and engaged in 43.8 (
SD
= 76.12) minutes daily of moderate level physical activity. Women reported higher satisfaction with activities (4.32 [
SD
= 1.14]) than men (3.85 [
SD
= 1.51]), and women received more medications than men (7.09 [
SD
= 3.51] vs. 6.34 [
SD
= 3.31]). Current study findings suggest that deprescribing may be particularly important for women versus men and focusing on expanding activity options to include those preferred by men should be considered in assisted living settings. [
Research in Gerontological Nursing, 13
(1), 31–40.]
The Usability of Physical Activity and Cognitive Training Applications in People With Mild Cognitive Impairment
Authors: Smith Lenora , Argentina Vinny
Published: October 2019

The aim of the current study is to identify key issues with utility, effectiveness, and appeal of specific electronic applications (apps) for people with mild cognitive impairment (MCI) to guide the design and development of a mobile app, which integrates physical activity and cognitive activities. Sixteen participants age ≥65 were recruited from three assisted living facilities in Alabama. Participants were observed playing a physical activity app and cognitive training app via a tablet on two separate occasions. Most participants agreed that Sworkit
®
, Elevate
®
, and 7-Minute Workout
®
were easy to use and fun, less frustrating, and they would recommend them to a friend. Most participants had questions regarding clarification about how to play the games. All (100%) participants smiled and appeared happy when playing the physical activity games, whereas only 35% smiled during the cognitive training games. The current study was instrumental in revealing that people with MCI can use technology and provide feedback regarding use of that technology. Individuals with impaired cognition should be recruited for participation in research for the knowledge they can provide researchers. [
Research in Gerontological Nursing, 13
(2), 64–72.]
Stability of the relationships among demersal fish assemblages and environmental-trawling drivers at large spatio-temporal scales in the northern Mediterranean Sea
Authors: Mérigot Bastien , Gaertner Jean Claude , Brind’Amour Anik , Carbonara Pierluigi , Esteban Antonio , Garcia-Ruiz Cristina , Gristina Michele , Imzilen Taha , Jadaud Angélique , Joksimovic Aleksandar , Kavadas Stefanos , Kolitari Jerina , Maina Irida , Maiorano Porzia , Manfredi Chiara , Micallef Reno , Peristeraki Panagiota , Relini Giulio , Sbrana Mario , Spedicato Maria Teresa , Thasitis Ioannis , Vittori Stefania , Vrgoc Nedo
Published: October 2019

Trawling pressure and environmental changes may affect the composition of fish assemblages. Our knowledge on large spatio-temporal patterns of demersal fish composition remains incomplete for the Mediterranean Sea. We investigated (1) the spatio-temporal stability of demersal assemblages, (2) the relationships between these assemblages and potential structuring factors (trawling pressure and environmental conditions) in order to assess the dynamic of the assemblage structure at the scale of the northern Mediterranean Sea. We analysed a dataset of 18062 hauls from 10 to 800 m depth performed annually during the last two decades across 17 Geographical Sub-Areas (GSAs) (MEDITS program). A multi-table analysis (STATICO-CoA) evidenced a strong inter-GSAs stability in the organization of assemblages, with specificities for some GSAs. The most stable structuring factors were linked to combined gradients of chlorophyll a, phytoplancton carbon biomass and temperature, inversely correlated with depth, salinity and nutrient gradients (axis 1 of the STATICO-CoA compromise, 93.74% of the total variability). A common pattern linking the distribution of species to these environmental gradients was evidenced for most of the 17 GSAs. Estimate of trawling pressure showed a minor role in the organization of the assemblages for the spatial scale and years investigated (axis 2, 4.67%).