bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementasi Asas Nasional Aktif dalam Tindak Pidana Pencucian Uang: Studi Kasus Perjalanan Panjang Kasus Nazaruddin
Authors: Atmaja Bisma Budi , Gayatri Annisa Zerlina Cindy , Anugrah Bima Sauma , Sihombing Johanes Saut Marganda
Published: February 2024

ABSTRAK

Tindak Kejahatan yang ada di Indonesia saat ini semakin beragam. Hal tersebut seiring dengan adanya perkembangan zaman. Salah satu kejahatan yang ada di Indonesia dan berdampak besar terhadap negara yaitu kejahtan korupsi dan kejahatan Tindak Pidana Pencucian Uang. Kejahatan tindak pidana pencucia uang di Indonesia semakin banyak. Para pelaku tindak pidana melakukan kejahatan yang dilarang dan bertentangan dengan hukum, kemudian keuntungan yang di dapatkan dari kejahatan tersebut diolah agar tidak diketahui bahwa harta itu merupakan harta hasil dari tindak pidana. Beragam cara dilakukan oleh pelaku agar uang tersebut tidak diketahui bahwa uang hasil tindak kejahatan, berbagai cara yang dilakukan dalam pencucian uang diantaranya mentransfer uang tersebut ke luar negeri kemudian diambil kembali untuk membangun perusahaan, uang hasil kejahatan ditanamkan sebagai modal perusahaan, disimpan dalam saham perusahaan. Pencucian uang yang dilakukan di luar negeri akan menyangkut banyak pihak. Dalam mengatasi permasalahan tersebut, diatur berdasarkan asas nasional aktif di Indonesia. Asas nasional aktif itu ada di ketentuan KUHP. Kejahatan tindak pidana korupsi dan pencucian uang harus ditangani dengan serius karena tindak pidana terseut merugikan keuangan negara. Salah satu kasus tentang kejahatan tindak pidana korupsi dan tindak pidana pencucian uang di Indonesia dilakukan oleh Nazaruddin sebagai anggota DPR. Nazaruddin melakukan suap pada proyek wisma atlet dan melakukan tindakan  pencucian uang dengan membawa uang tersebut ke luar negeri lalu membawa kembali ke Indonesia dan digunakan sebagai modal saham perusahaan. Nazaruddin melarikan diri ke luar negeri dan bersembuyi dibeberapa negara, akan tetapi keberadaannya bisa diketahui sehingga dipulangkan dari negara yang menjadi tempat persembunyiannya dan kembali ke negara Indonesia untuk menjalani proses hukum.
Characteristics of the ‘ecological consciousness’ concept: Content and definition within the framework of an interdisciplinary method
Authors:   State University of Education, Filipchenko Anton D.
Published: February 2024

The most important factor of taking suitable response measures to combat current environmental challenges is a complete and comprehensive description of the environmental consciousness phenomenon. The identification of links between the internal ecological worldview of a person and social norms and regulations let influencing the environmental behavior of entire states by methods of education and culture. In this regard, it is necessary to explain the content of the ecological consciousness concept, which is possible only if you take an interdisciplinary approach to research. In this work, ecological consciousness is analyzed from the ecological component and the philosophical theory of consciousness points of view, described by the key domestic and foreign positions on the issue of describing the content of this phenomenon. For this purpose, historical and problematic issues of formation of ecological discourse and, in fact, of ecological consciousness itself in domestic science are investigated. At the end of the article, several key characteristics of ecological consciousness, based on the generalization of the studied material, are presented, as well as its experimental definition is proposed, designed to reflect the internal complexity and interdisciplinary nature of the required concept.
Managerial leadership in the eyes of Military Institute Cadets: A sociological assessment
Authors:   Saratov Military Order of Zhukov Red Banner Institute of National Guard Troops of the Russian Federation, Korchagin Maxim V.
Published: February 2024

The essence of the management leadership category is being specified. The selective results of the sociological survey “Leadership in the modern military team” are presented, conducted among the cadets of the Saratov Military Institute. Based on a theoretical and practical study, subjective assessments of managerial leadership by cadets are presented. It is justified that within the framework of the modern military team, an important role in preparing for the fulfillment of the assigned tasks and preparing subordinates to fulfill their duties (official and special) belongs to the commander, who, on the one hand, is a leader — a military official appointed by a higher body of military or state administration, and on the other hand, a leader — a leading military professional among his subordinates — members of the military team of a unit (unit). If his actions as a leader are mainly based on the strength of his administrative power, then as a management leader — on the strength of the public (group) opinion and collective mood of military personnel who recognize his merits, authority and respect for him, for his professionalism. It is proved that management leadership is a collective relationship between a manager and team members (boss and subordinates), built not only on his formal endowment with an administrative resource (power), but also on the acceptance and respect by the rest of the team members of this leader (boss), the definition and understanding of common goals, the distribution of formal and informal roles in this team. Management leadership is externally manifested as a system within the collective relations between the leader and members of the team (the head and subordinates), built not only on his formal endowment with an administrative resource (power), but also on the adoption and respect by the rest of the team of this leader (the head), the definition and understanding of common goals, the distribution of formal and informal roles in this team. It has been proven that within the framework of the functioning of a military institute, management leadership is a really achievable result of educational activities, its ultimate goal, which allows, determined by the requirements for the upcoming position, taking into account the specifics of the military team.
How students were helped a hundred years ago
Authors:   Emperor Alexander I St. Petersburg State Transport University, Platova Elena E.
Published: February 2024

The article is dedicated to the 100th anniversary of the organization of state aid to students in Russia. The article presents an analysis of the activities of the Commission for Improving the life of Students in Russian universities (KUBUCH), which can be considered as an attempt of the first systematic approach to the organization of fi nancial assistance to students. The article also examines the prerequisites for the emergence of this organization, determines the role of KUBUCH in the daily life of students, its place in the life of higher educational institutions and the entire system of training specialists for the national economy of the country, when the higher school overcame class prejudices, was built on broad democratic principles.
Semantics and ethnoculture: topicality in the study of the Khanty language
Authors:   Khakass State University named after N.F. Katanov, Kaksin Andrey D.
Published: February 2024

The article is devoted to the delimitation of hidden and formally expressed imagery in the language (namely, in the lexicon, that is, the vocabulary of the language). In the first case, imagery is understood as the semantic non-triviality of the origin of a word due to its internal form or etymology (if this particular postulated path of origin is proved). Formalized is considered imagery, the means of expression of which are widely used in the languages of the scheme of “transferring” the word meaning, creating epithets, comparisons, personifications, hyperbole. The article considers one of the most important linguistic semantic phenomena — the creation of new lexemes, based on existing units, in some formal way (suffixation, verbiage), reinforced by semantic transformation. Additionally, if possible, binding to the features of ethnic culture is made. As a result of the study, the concept of imagery was formulated in relation to the vocabulary (or lexicon) of the language, a distinction was made between hidden and formally expressed imagery. The empirical basis of the study was compiled by dictionaries of the Khanty language, as well as lexical material presented in one of the fundamental works on Finno-Ugric studies — the collective work “Fundamentals of Finno-Ugric linguistics” (1974). The main research methods are descriptive method, taxonomy, as well as comparison. A typological approach is used in the general assessment of word formation methods.
Genre peculiarties in Christopher Buckley’s novel “The White House Mess”
Authors:   Uzbek State University of World Languages, Pulatova Diyora F.
Published: February 2024

This article considers the debut novel of the contemporary American satirist Christopher Buckley. In particular, author of this article states that this novel typologically belongs to “a political farce novel”. Thus, the analysis is done accordingly to the characteristics of the mentioned genre type. Consequently, in the article the main bias is made on the political component of the narrative, therefore satirical images are not fully presented in the article. The purpose of this article is to draw attention to the problem of genre originality of the modern American political satirical novel. The result of this article is the thesis that political satirical novel is the genre that allows writers to most fully reveal their visions of political mechanisms and identify patterns within the political system.
The media and journalistic context of A.A. Blok’s essay “The Last Days of Imperial Power”
Authors:   Institute of Russian Literature (Pushkin House) of the Russian Academy of Sciences, Kolesnikova Elena I.
Published: February 2024

The article examines the media background on which A. Blok’s essay “The Last Days of Imperial Power” was created, which was the result of his work as part of the Extraordinary Commission of Inquiry. Structural and meaningful similarity with the book by S.Ya. Streich “The Last Days of Nicholas II. Official Documents. Eyewitness accounts”, written in 1917, remained out of sight of the researchers. An analysis of the concepts of chronotope, beginning, architectonics is given. The documents presented in both essays are considered. The style differences between Streich and Blok’s essays are described. Streich is a publicist. Blok’s essay has the perspective of an art-documentary genre that will spread widely in the 20th century. Excerpts from Blok’s diary are given, in which what he saw while working in the Peter and Paul Fortress develops into sketches, and artistic images are outlined. A source is being established that A. Blok used when publishing a letter from Grand Prince Alexander Mikhailovich is being established. The origins of the original title of Block’s essay and the reason for its change are considered. A hypothesis has been proposed about the origin of phraseologism ‘old mode’. It is concluded that Blok’s essay was formed in an active information environment saturated with journalism, genuine documents and testimonies of contemporaries. Many works of this time echo meaningfully. There was a mutual influence — both materials and methods of their submission were used. But regardless of the direct influence of specific works on each other, the authors lived in a significant turning point, generating typological forms of reflection of what is happening.
Attitude of clinical teachers towards the use of innovative technology in teaching and learning in the university of Port Harcourt medical school, South Nigeria
Authors: Wananyo Ugboma Enighe , Ebi Awotua-Efebo , Ibi Erekosima
Published: February 2024

The 21st century has seen a rapid increase in the use of various innovative technologies in pedagogy. The attitude of the clinical teachers affects the use of these innovative technologies in teaching and learning. The aim of this research is to find out the attitude of clinical teachers using “The Tripartite Theory of Attitude” consisting of affective, cognitive, and behavioral domains, to the use of innovative technology. A descriptive survey research design with correlational studies was done with a purposive sampling method used. A 24 item Likert questionnaire was used and distributed using Google Form. The population of the study was made up of clinical teachers in the Faculty of Clinical Sciences University of Port Harcourt.  A total of 90 clinical teachers took part in the study comprising of 48 males and 42 females. 23 were professors while 51 were senior lecturers. Analysis showed the overall attitude of clinical teachers to the use of innovative technology in teaching and learning was positive. No significant correlation was seen between gender, cadre, and years of service of the clinical teacher to the use of innovative technology. Thus, incorporation of innovative technology into the classroom should be encouraged as this would aid the clinical teachers in improving learning in the classroom.
Evaluasi Stasiun Kerja Industri Garmen dengan Motion Study
Authors: Yudhistira Gisya Amanda , Utami Rona Sutra Dewangga Dyah , Astuti Rahmaniyah Dwi , Qurtubi Qurtubi
Published: February 2024

Keberlanjutan suatu perusahaan berkaitan dengan kinerja sumber dayanya, dan tentu idak terlepas dari manajemen sumber daya manusia dan kegiatan operasional yang ada. Seperti pada industri garmen, banyaknya sumber daya harus dikelola dan diawasi dengan baik guna mencapai kinerja yang diinginkan. Hasil observasi awal ditemukan ada tidak kesesuaian antara rata-rata hasil produksi 40 unit per jam dengan ketercapaian produk yang ada yaitu 33 unit per jam. Sehingga perlu identifikasi lanjutan untuk menyelesaikan permasalahan ini. Menggunakan metode motion study, di proses proses penyatuan panel dan aksesoris, diketahui pada tangan kanan terdapat 99 gerakan efektif dan terdapat 10 gerakan tidak efektif, pada tangan kiri terdapat 16 gerakan efektif dan gerakan 21 tidak efektif. Di proses penjahitan zipper otomatis, pada tangan kanan terdapat 13 gerakan efektif dan tiga gerakan tidak efektif, pada tangan kiri terdapat 12 gerakan efektif dan 6 gerakan tidak efektif. Sehingga perbaikan layout sangat direkomendasikan untuk mengurangi ketidakefektifan gerakan kerja.
Detection of Malware Attacks using Artiﬁcial Neural Network
Authors: Rana Humza , Minhaj Ahmad Khan
Published: February 2024

Malware attacks are increasing rapidly as the technology continues to become prevalent. These attacks have become extremely difficult to detect as they continuously change their mechanism for exploitation of vulnerabilities in software. The conventional approaches to malware detection become ineffective due to a large number of varying patterns and sequences, thereby requiring artificial intelligence-based approaches for the detection of malware attacks. In this paper, we propose an artificial neural network-based model for malware detection. Our proposed model is generic as it can be applied to multiple datasets. We have compared our model with different machine-learning approaches. The experimentation results show that the proposed model can outperform other well-known approach as it achieves 99.6\% , 98.9\% and 99.9\% accuracy on the Windows API call dataset, Top PE Imports Dataset and Malware Dataset, respectively.
Nutritional Quality of Diets of Adults (20-40 Years) in Delhi, India
Authors: Mediratta Srishti , Mathur Pulkit
Published: February 2024

Rise in prevalence of diet related non communicable diseases can be prevented by following balanced and healthy diets. The study aimed to assess adequacy of nutrient and food group intakes along with frequency of consumption of foods High in Fat, Sugar and Salt (HFSS). The study was a cross-sectional study with non-probability purposive sampling method. A total of 589 adults (20-40 years) were selected from housing colonies from four geographical zones of city. Dietary intake was assessed using 24-hour dietary recall method. Frequency and amount of foods consumed was recorded using a semi quantitative Food Frequency Questionnaire (FFQ). The differences in food groups and nutrient intakes across socio-demographic groups were assessed using Independent sample t-test and Mann-Whitney U test. Statistical significance was assumed at 5% level (p<0.05). Most participants had nutrient intakes lower than the EAR for calcium (97%), zinc (98%), riboflavin (100%), niacin (68%), vitamin B6 (96%) and vitamin A (60%). All participants had lower intakes of pulses, green leafy vegetables, other vegetables, fruits, milk and milk products, oilseed and nuts when compared to the recommended intakes. HFSS foods-sweet plain biscuits (46%), fried namkeen (37%), roasted namkeen (30%), non-carbonated drinks (29%) and deep-fried foods (25%) were eaten regularly by more than one fourth of participants. Participants occasionally consumed pizzas (60%), chat (54%), dosa (50%) and burgers (48%). Therefore, reducing the share of foods high in fat, sugar and salt and enabling healthier selection of food groups through behaviour change communication strategies will ensure adequate nutrient intakes.
Chemical Composition, Characterization and Antioxidant Property of a Food Additive Prepared from Vigna Mungo (Black Gram Lentils) Plant Waste
Authors: Mazumder Deepjyoti , Narzary Alakes , Nath Suresh K.
Published: February 2024

Assam is a state of North East India and the tribal and non-tribal people here use different naturally available food materials and modify those through traditional processes for preservation and utilization for the purpose. An ethnic food additive called Khar, prepared from Vigna mungo (Black gram lentils) plant waste; its chemical parameters and antioxidant properties has been studied in this work. The pH, alkalinity, hardness, metal content, and functional groups present in the ash sample and the extract are determined using titration method, atomic absorption spectrophotometer, SEM-EDX and FTIR. Some essential minerals present in the sample are K, Na, Mg, Ca, Cu, Mn, Fe, etc. and the basic property of this additive makes it as a good antacid.
Anti-Diabetic Potential of Natural Plant Sources: An Assessment of Awareness and Consumption among Diabetics
Authors: Jain Divya , Singla Neerja , Kumar Rajender
Published: February 2024

Diabetes is a leading cause of death in developing countries, and there is a growing interest in utilizing natural remedies to manage high blood sugar levels. This study aimed to evaluate the awareness and usage of traditional plant-based treatments among diabetes patients. A cross-sectional survey was conducted on 500 diabetic patients in Ludhiana hospitals' Outpatient Departments (OPDs). A structured questionnaire gathered data on demographics, socioeconomic status, medical history, hyperglycemia management, and awareness and utilization of 22 traditional anti-diabetic plants. The results showed that the majority (55.2%) focused on dietary control, followed by exercise (49.6%) and oral hypoglycemic medications (46.8%). Interestingly, a higher percentage of female diabetics (56.3%) engaged in exercise compared to males (44.2%), while insulin use was reported by 17.2%, and only 19.2% used herbal supplements. A majority (62.4%) of subjects reported awareness of the listed plant sources as potential anti-diabetic agents. Notably, fenugreek seeds, bittergourd, ginger, and holy basil were the most recognized plants, acknowledged by 55.2, 47.2, 44.4, and 40.8% of respondents, respectively. In the study, awareness of garlic as an anti-diabetic remedy was significantly (p<0.05) higher among females (40.6%) compared to males (31.3%), while males exhibited significantly (p<0.05) greater awareness of tulsi's anti-diabetic properties. Interestingly, a relatively higher percentage reported consuming garlic (34%) as part of their diabetes management, either as a remedy or in meal preparations, followed closely by holy basil (32.6%), bittergourd (31.4%), and fenugreek seeds (28.2%), it's apparent that only a small fraction actually incorporated these plants into their daily routines. This underutilization of readily available and cost-effective remedies in India may be attributed to the lack of substantial clinical data supporting their efficacy. The study highlights the gap between awareness and practical adoption of traditional medicinal plants among diabetics, despite their accessibility and affordability in India. Urgent efforts are needed to document ethnobotanical knowledge before it vanishes, and further initiatives should promote the utilization of traditional medicinal plants as a complementary approach to control hyperglycemia.
Review on Bioactive Metabolites of Asparagus racemosus and its Pharmacological Significance
Authors: Divya  , S. N. Naik , P. Hariprasad
Published: February 2024

Naturally, genealogical people for different symptoms are nearly new to therapeutic traditional plant active components, Shatavari, a valuable plant growing worldwide. This review provides an overview of Asparagus racemosus and the components of Asparagus racemosus used in entirely new combination of ingredients, have applications in industry as well as medicine. This plant is growing in popularity because to its nutrient-rich root, leaves, blossoms, and fruits. It also has a long history of medical use and is known to possess qualities that are beneficial to medicine. Asparagus racemosus, usually in therapeutic approach for the cancer of the liver, brain disorder, has the main role in milk secretion in pregnant women and regulate sexual behavior. This plant may be a reliable source of bioactive constituents like steroidal saponins, Shatavarins the most important bioactive parts in an exceedingly. A. Racemosus are finding applications due to various potential functions like immunomodulant, galactagogue, antioxidant, anti - inflammatory, antimutagenic, inhibitor, or antiulcer, boosting the lifestyle for humans. Ayurveda suggested it is for interference and treatment of gastrointestinal ulcers, dyspepsia and galactagogue. There has been no scientific proof detected in Shatavari based mostly Nutra beverage considering the range of secondary metabolites present in it their bioavailability and their health advantages. Therefore, the fermentation of Shatavari in Nutra beverages is a developed area of research for the event of different Nutra beverages, which may cause not only supply a lot of nutrition but prevent and therapeutic common diseases additionally.
Nutritional and Nutraceutical Advantages of Small Millets and Their Role in Prevention of Life Style Disorders
Authors: K. P. Chandankumar , A. Jayadeep , Singh Sridevi A.
Published: February 2024

Millets in general and the small millets in particular, consumed in whole form with its botanical parts such as endosperm, bran and germ, are rich in nutrients and phyto-nutrients. Important cultivated small millets are finger millet, little millet, kodo millet, foxtail millet, barnyard millet and proso millet. Each millet is unique in their content of nutrients and phyto-components with health beneficial effects or nutraceuticals. Bioactive components in the millet include- phenolic acids, flavonoids, phytosterols, tocopherols, carotenoids, small peptides, dietary fibre, etc. These components as well as small millet fractions can influence the biochemical and molecular pathways in metabolic syndrome and play key role in prevention of life style disorders.
Biofortified Pearl Millet Varieties for Sustainable Agriculture among farming community in Theni District, Tamil Nadu
Authors: M. Ramyasivaselvi , S. Kowsalya , S. Juliet Hepziba
Published: February 2024

Pearl millet (Pennisetum glaucum-Bajra) is a unique and important nutri cereal for food and nutritional security and drought-tolerant coarse-grain cereal. Pearl Millet offers a plethora of health benefits and is also good for the environment with low water and input requirements for production. The present study was framed to assess the suitable biofortied Pearl millet variety under rainfed situation in Theni District and its nutritional security, and farmer revenue. The primary objective of the trial was to evaluate newly released different biofortified varieties, technologies, management practices and post-harvest management at farmers’ fields under real farming situations under different agroclimatic regions. The On-farm trial was conducted during Kharif season, to study the performance of different short-duration and high-yielding Biofortified pearl millet varieties for sustainable Agriculture in rainfed regions of Theni District. Randomized Block Design (RBD) was used to arrange the experimental plot in five replications with Dhanasakthi, ABV 04 and CO10 biofortified pearl millet varieties. The recommended cultivation practices were followed during the trail period. As part of the study, training cum method demonstration was conducted on different storage techniques. Need based skill trainings cum method demonstrations were conducted to 60 farmers. Experiments results relvealed that Dhanasakthi variety matured on 81 days followed by ABV 04 (83.66 days). The Pearl millet variety CO10 matured on 91.16 days. The greater number of productive tillers (6.36) was recorded in CO10 variety followed by 5.7 in ABV 04. The highest panicle length was recorded (40.90 cm) in CO10 followed by Dhanasakthi (29.33 cm). The highest yield was recorded in CO10 (33.64 q/ha) followed by ABV 04. Regarding the Benefit Cost Ratio (BCR), CO10 recorded 4.31 followed by ABV 04 (2.79). The study conclude that CO10 Pearl millet variety is highly adopted by the farmers compared to two other varieties. Regarding storage technique, They prefer to store the grains by sand layer technology and pepper seed powder in IRRI Bag. The farmers gained knowledge on value chain management from 48-70 percentage. This knowledge and skills on value chain management of biofortified pearl millet varieties would help them to get an idea to start entrepreneur units in their villages for sustainable income generation.
Gestión por procesos y satisfacción del cliente según colaboradores de la banca PYME del Banco de Crédito del Perú en Lima Metropolitana, 2021
Authors:   , Santos Quispe Deyli , Villavicencio Cueva Yannely Berliz
Published: February 2024

El propósito del estudio fue determinar la asociación entre la gestión por procesos y satisfacción del cliente según colaboradores internos de la banca pyme del Banco de Crédito del Perú en Lima Metropolitana, 2021; para tal efecto se realizó la revisión literaria, citando a autores que habían abordado las variables en mención. Se efectuó una investigación con diseño no experimental transeccional correlacional-causal, con un enfoque cuantitativo; la muestra fue de 186 funcionarios que trabajaban en Lima Metropolitana, quienes los cuales respondieron 26 preguntas de manera virtual, las cuales fueron previamente validadas por jueces expertos y cuya confiabilidad se definió mediante el coeficiente alfa de Cronbach. Asimismo, se utilizó el software estadístico IBM SPSS Statistics versión 26 para el análisis de datos, y se concluyó que existe una relación débil y significativa entre las variables de estudio, con un coeficiente Rho de Spearman de 0.197.
Asociación entre la percepción del uso apropiado de antibióticos y del incremento de resistencia antibiótica en trabajadores de la salud
Authors:   , Contreras Mercado Alejandro Eduardo , Nuñez Cotrina Jorge Carlos
Published: February 2024

OBJETIVO: Determinar la percepción del uso apropiado de antibióticos y la percepción del incremento de la resistencia antibiótica en los trabajadores de salud de Lima Metropolitana. MÉTODOS: Estudio transversal. Se obtuvieron variables sociodemográficas como el sexo, la edad, variables relacionadas a las características del personal, variables relacionadas con los criterios de prescripción y variables relacionadas con el escenario de la práctica clínica. Para evaluar dicha percepción se brindó una encuesta anónima virtual a trabajadores de salud que prescriben antibióticos. RESULTADOS: Participaron 263 trabajadores, siendo varones el 65.73% y médicos, 74.14%. La mediana de edad fue 45 años (40-50), mientras que la mediana de años de experiencia fue 10 años (8-15). Provenían de centro de salud 61.22%, y un 41.83% tenían una especialidad clínica. Hubo 100% de inseguridad en la dosificación e intervalo, mientras que la seguridad de escoger vía de administración fue 99%. Las categorías restantes tuvieron rangos entre 8-57% de seguridad. En los contribuyentes a resistencia, la cantidad y la indicación de antibióticos de amplio espectro, obtuvieron 100% de importancia, y 93%, la percepción de duración de tratamiento. Las categorías restantes tuvieron rangos entre 37-73% de seguridad. Al comparar las respuestas entre centros de salud y hospitales, no se muestran diferencias importantes en cada factor. CONCLUSIÓN: En trabajadores de salud, la percepción de inseguridad de uso apropiado de dosificación e intervalo fue muy alta; mientras que en contribuyentes a la resistencia, percepción de la cantidad e indicación de antibióticos de amplio espectro fue elevada.
Efectividad de la Técnica de Jacobson en la disminución del estrés, ansiedad y depresión en pacientes con COVID-19, Lima – 2021
Authors:   , Marquina Gutiérrez Susi Natali , Molleapaza Condori Felina Rosmery
Published: February 2024

La presente investigación tuvo como Objetivo: determinar la efectividad de la técnica de Jacobson en la disminución del estrés, ansiedad y depresión en pacientes con COVID-19, Lima- 2021. Metodología: se apoya en la base del enfoque cuantitativo, cuenta con un nivel explicativo, cuyo diseño es pre-experimental de un solo grupo de pre-test y pos-test y de corte longitudinal, dirigido a un grupo poblacional conformado por 48 individuos y con una muestral final de 42. Como técnica de investigación fue utilizada la observación y como instrumento el DASS 21. Resultados: Se aceptó la hipótesis de investigación con un valor significativo de P= 0,005; en el pre-test, el 54,8% presentó estrés moderado, el 33.3 % presentó ansiedad extremadamente severa, el 54,8% presentó depresión moderada; en el pos-test se halló que el 100% presentó estrés leve, 59,5 % ansiedad moderada y el 90,5% depresión leve. Conclusión: la técnica de Jacobson permitió disminuir significativamente la sintomatología de estrés, ansiedad y depresión en pacientes con COVID-19, Lima-2021.
Asociación entre anemia y ganancia de peso en mujeres en el tercer trimeste de gestación del distrito de Ate - 2017
Authors:   , Santaya Paul Jimena Isabel , Chifu Kuan Melisa Vanessa
Published: February 2024

Objetivos. Analizar si existe asociación entre anemia y la ganancia de peso en el tercer trimestre de gestación. Materiales y métodos. Estudio transversal en el cual se analizó una base de datos (2017) del Instituto Nacional de Salud (INS) y Centro Nacional de Alimentación y Nutrición (CENAN), sobre gestantes registradas en historias clínicas de establecimientos de salud del Perú. Se seleccionaron 2452 gestantes desde la semana 28 de gestación y embarazo único. Se aplicó análisis descriptivo y estadística inferencial. Resultados. Con nivel de confianza del 95,0%, el aumento de peso del tercer trimestre respecto al peso pregestacional fue entre 7,5 kg y 8,4 kg en gestantes con anemia y entre 7,6 kg y 8,1 kg en gestantes sin anemia. Las gestantes con delgadez y normalidad (IMC) tuvieron una ganancia de peso gestacional más baja y presencia de anemia en mayor número de ellas. No se encontró relación entre anemia con ganancia de peso gestacional (Chi cuadrado: 1,68). En cuanto a la regresión logística, el peso pregestacional demostró una fuerte asociación con anemia (p<0,05). Se encontró correlación baja directa entre gestantes sin anemia con sobrepeso y ganancia de peso gestacional adecuada (r: 0,14; p<0,05), y gestantes sin anemia con obesidad y ganancia de peso gestacional alta (r: 0,28; p<0,05). Conclusiones. Hubo asociación baja entre ganancia de peso gestacional y anemia en gestantes en el tercer trimestre de gestación.
Análisis de contenido de estilos de vida saludable en Instagram: errores frecuentes en publicaciones de influencers
Authors:   , Rodríguez Gómez Lucía Belén Guadalupe
Published: February 2024

Introducción: Las “influencers”, líderes de opinión en entornos digitales, publican contenidos en nutrición y salud con errores en el manejo de información sobre “fajas reductoras”, “recetas/dietas” y “productos mágicos”. Ello puede impactar negativamente a sus seguidores, sin distinción de sexo o edad, en su formación de conocimiento y toma de decisiones respecto a su salud. Objetivo: Identificar a través de métodos cualitativos los errores en la información proporcionada en Instagram sobre temas de nutrición a partir de las cuentas creadas por influencers peruanas que comparten información sobre nutrición y salud. Metodología: Se realizó un análisis de contenido a 5 influencers peruanas y se analizó las publicaciones e historias destacadas en Instagram entre diciembre y mayo de 2020. Se identificó como casos de estudio a las que tuvieron menor y mayor número de posteos con errores de contenido y se realizó un estudio descriptivo cualitativo de análisis de contenido de estos perfiles. Además, se realizó la técnica de pseudocompra a 2 influencers dedicadas a la venta de “productos mágicos” analizando el error en la información de dichos productos. Resultados: 26 errores fueron encontrados en las publicaciones de la Influencer 3, quien realizó 29 publicaciones, representando un 89.7% de error en contenido. La influencer 5 no presentó errores en sus publicaciones respecto a temas de nutrición y destacó la importancia de acudir a un profesional de salud para asesorías. Conclusiones: Se concluye que la información brindada por ciertas influencers es errónea respecto a temas de “fajas reductoras”, “dietas” y/o “productos mágicos” ya que, tras ser comparada con evidencia científica, se demostró que no hay respaldo científico de la información brindada.
Influencia de modelos de conducta y factores personales en la elección de una especialización en estudiantes de Ingeniería de Sistemas de Lima-Perú, 2022
Authors:   , Peña Miranda William Francisco
Published: February 2024

Probamos el modelo de Objetivos de Elección de Especialización de Akbulut (2016) a datos por género y tipo de universidad a fin de comprender la influencia de los modelos de conducta en la elección de una especialidad de Sistemas de Información. Utilizando SEM, se evaluaron a 257 estudiantes de universidades privadas y públicas de ingeniería de sistemas de Lima. Los modelos de conducta influyen indirectamente en los objetivos de elección. Sin embargo, se evidencia que, en las mujeres los modelos de conducta si influencian al elegir una especialización. Asimismo, los modelos de conducta impactan directamente en la autoeficacia, intereses y expectativas de resultados. El análisis multigrupo por tipo de universidad, evidencia que, en los estudiantes de universidades privadas, los modelos de conducta impactan en sus expectativas, todo lo contrario, con sus homólogos de universidades públicas. La autoeficacia de los estudiantes de las universidades públicas es influenciada en mayor proporción por sus modelos de conducta, en comparación a sus homólogos de universidades privadas. Se validó el modelo de Akbulut, sin embargo, el análisis multigrupo por género evidenció una influencia de los modelos de conducta en estudiantes mujeres. Se corroboró la influencia de los modelos de conducta en la autoeficacia, las expectativas de resultados y los intereses. Las expectativas de resultados no influencian en el interés, estos resultados difieren con (Akbulut, 2016).
RETRACTED: The impact of COVID-19 news on the mental health of Bahrainis
Authors: Aldoseri Marwa , Alhadi Noora , Alghatam Latifa , Abdulla Shoog , Alrayes Hala , Aldoseri Fajer , Almudahka Danat , Hasan Retaj , Shareeda Shoog , Alzobbae Lena , Almarabheh Amer , Ahmed Jamil
Published: February 2024

The authors have requested that this preprint be removed from Research Square.
Kunzea ericoides (kanuka) leaf extracts show moisturisation, anti-oxidant, and UVB-protection effects in HaCaT cells and anti-melanogenesis effect in B16F10 cells
Authors: He Xuefeng , Li Peishan , Zhao Shixin , Liu Hengdeng , Tang Weijian , Xie Julin , Tang Jinming
Published: February 2024

The present study identified various compounds, such as chlorogenic acid, gallic acid, quercetin, and (E)-Ferulic acid in the kunzea ericoides (kanuka) leaf extract, showing its potential use in maintaining skin health. The influence of kanuka leaf extract upon epidermal cells concerning cytotoxicity and in vitro activities of moisturisation, anti-oxidation, UVB protection, and anti-melanogenesis effects were explored in the study. Kanuka leaf extract demonstrated significant promotion in the proliferation of HaCaT and B16F10 cells. After incubation with kanuka leaf extract, the content of ROS and DPPH in HaCaT was significantly decreased; at the same time, more SOD was produced. Furthermore, hyaluronidase-1 (HYAL-1) and HYAL-4 expressions were inhibited, while the aquaporin 3 (AQP-3) content was significantly increased. Kanuka leaf extract also inhibited the expressions of matrix metalloproteinases-1 (MMP-1) and MMP-14 in UVB radiated-HaCaT cells. In the B16F10 cell line, melanin and tyrosinase production were decreased under the presence of kanuka leaf extract, and the expressions of microphthalmia-associated transcription factor (MITF), tyrosinase-related protein-1 (TYRP-1) and TYRP-2 were also inhibited.
Uncertain programming model for fixed charge multi-item solid transportation problem with compensate for loss.
Authors: Zhao Yunpeng , Liu Xue Ling , Wang Hongwei , Liu Xue , Liu Liying
Published: February 2024

In this paper, the solid transportation problem with fixed rate and loss compensation is studied, in which the loss compensation includes the reissue cost and the loss compensation cost. Since there are a lot of indeterministic factors in the whole transportation process, it is assumed that the supply, demand, loss, fixed charge, and transportation volume in the model are regarded as uncertain variables. An expected value model and a chance-constrained model are constructed using the expectation value criterion and the chance constraint criterion, respectively. The particle swarm optimization and seagull optimization algorithms calculate the optimal results of the two models. The advantages and disadvantages of these two algorithms are analyzed using the analytic hierarchy process. Finally, numerical experiments show the application of the model.
The role of the Golden2-like (GLK) transcription factor in regulating chlorophyll and terpenoid indole alkaloid biosynthesis in Catharanthus roseus
Authors: Cole-Osborn Lauren F. , McCallan Shannon A. , Prifti Olga , Abu Rafay , Sjoelund Virginie , Lee-Parsons Carolyn
Published: February 2024

Catharanthus roseus is the sole source of the chemotherapeutic terpenoid indole alkaloids (TIAs) vinblastine and vincristine. TIAs are produced at higher levels in immature versus mature leaves, but the molecular mechanisms responsible for this developmental regulation are unknown. We investigated the role of GOLDEN2-LIKE (GLK) transcription factors in contributing to this ontogenetic regulation since GLKs are active in seedlings upon light exposure and in the leaf’s early development, but their activity is repressed as leaves age and senesce. We identified a GLK homologue in C. roseus and functionally characterized its role in chlorophyll and TIA biosynthesis by transiently reducing its expression through two separate methods: virus-induced gene silencing and application of chloroplast retrograde signaling inducers, norflurazon and lincomycin. These experiments confirmed that CrGLK positively regulates chlorophyll biosynthesis and the expression of the light harvesting complex subunit (LHCB2.2), consistent with its function in other plant species. In contrast, reducing CrGLK increased TIA accumulation and TIA pathway gene expression, specifically vindoline biosynthesis, suggesting that it may instead repress TIA biosynthesis. Interestingly, while lincomycin treatment led to significant increases in TIA gene expression, norflurazon had no effect, suggesting that reducing CrGLK alone was not sufficient to induce TIA biosynthesis, and providing a clue for future investigations of TIA regulation. This is the first identification and characterization of GLK in C. roseus and the first investigation of how chloroplast retrograde signaling might regulate TIA biosynthesis.
Assessment of Different Strategies for ROI-Based Measurements of Proton Density Fat Fraction in NAFLD
Authors: Lu Jingyi , Xia Youchen , Mu Rong , Luo Qian , Zhang Lei , Zhu Kouyun , Cai Xiaobo , Lu LunGen , Qu Ying
Published: February 2024

Aims:

MRI-PDFF is a promising non-invasive method of quantifying liver fat. This study assessed the reproducibility and repeatability of MRI-based PDFF in NAFLD patients, the consistency between different ROI sampling strategies, as well as the learning time burden of PDFF measurement.

Methods:

90 NAFLD patients and 30 healthy people were enrolled in this cross-sectional study. Three reviewers measured liver PDFF by circling ROIs in four segments, nine Couinaud segments, and a random place on the PDFF map, respectively. Bland-Altman analysis and ICC were used to evaluate the inter- and intra-reviewer agreements for liver PDFF.

Results:

Circling ROIs within nine Couinaud segments had the narrowest limit of agreement (LOA) for PDFF measurements. For all 120 subjects, the intra-reviewer agreement had mean LOA of ±0.9% for three strategies, while the inter-reviewer agreement had mean LOA of ± 0.93%. We additionally determined that inter-group consistency increased with decreasing liver fat content for all ROI-circling strategies. The CUSUM learning curve shows that after 17 cases, beginners circled the ROIs more efficiently and accurately.

Conclusions:

Researchers and clinicians can circling one random ROI for mass screening of patients with NAFLD. We suggest training beginners perform at least 17 PDFF maps to acquire reliable data.
Wnt signaling alters CTCF binding patterns and global chromatin structure
Authors: Cantù Claudio , Nordin Anna , Chakraborty Chaitali , Jonasson Mattias , Dano Orgena , Zambanini Gianluca , Pagella Pierfrancesco , Remeseiro Silvia
Published: February 2024

Wnt signaling plays a pivotal role during development, stem cell maintenance, and tissue homeostasis. Upon Wnt pathway activation, β-catenin translocates to the nucleus where it binds the TCF/LEF transcription factors to drive the context-specific expression of Wnt target genes. Coordinating gene expression programs in vertebrates requires a complex interplay between the regulatory and the 3D organization of the genome. However, the impact of Wnt signaling on genome structure has been poorly explored. Here we investigated how Wnt signaling activation influences the binding patterns of CTCF, one of the core architectural proteins that helps establish the 3D genome organization by demarcating topologically associated domains (TADs). This study uncovered a series of CTCF rearrangements under Wnt, that we termed RUW. Notably, RUW sites that were gained upon Wnt activation were typically dependent on β-catenin and were characterized by both CTCF and TCF/LEF binding. Accordingly, many CTCF RUWs aligned with β-catenin binding patterns, and β-catenin and CTCF co-localized in vivo in discreet nuclear puncta only upon pathway activation. Genome-wide investigation of CTCF-mediated 3D genomic interactions upon Wnt pathway stimulation supported the role of the identified RUWs in mediating Wnt-dependent chromatin loops. Lastly, targeted disruption of selected CTCF binding sites demonstrated their functional contribution to Wnt target gene regulation, implicating regulation of the 3D genomic structure in the execution of transcriptional programs orchestrated by developmental pathways.
Investigation on the pollution status of hand washing facilities in use on the surrounding environment
Authors: wang xueyu , TIAN Fang-Ying , Meng haopeng , Kang jianbang , Zhao ming , Wang hongwei
Published: February 2024

Aim To detect the pollution of faucets in hospitals and the splash during hand washing, and to explore the reasonable layout of hand washing pools.
Methods Two faucets with roughly the same spatial layout in the ICU of a third-class first-class general hospital were selected, and the farthest splashing distance and specific splashing points were measured by color paper. Samples were detected by ATP detection technology and routine microbial detection method, and the pollution of faucets was analyzed.
Findings After 72h of daily hand-washing activities, the furthest distance to the splash point was about 100cm around the faucet, and the place 40cm-110cm around the faucet was polluted seriously. The farthest distance that the splash point reached was about 80cm around the faucet with the center of the circle, and the area 40cm-60cm around the faucet was heavily polluted. The distance from the water outlet of the long handle and the short handle faucet to the detection point had a high negative correlation (r = − 0.811, P<0.001) and a moderate negative correlation (r=−0.475, P=0.001) with the number of splash points, respectively. The qualified rates of ATP detection and microbial culture were 25% and 15%, respectively. Pseudomonas aeruginosa, Staphylococcus epidermidis, and other pathogenic bacteria were detected in the water outlet of the faucet and the surrounding environment.
Conclusion Safe hand-washing facilities are the guarantee of hand hygiene effect. Clean objects and objects related to patients should not be placed within 1m range near the water outlet of faucet. Anti-splash baffle should be installed as much as possible when conditions permit to reduce the pollution caused by splash during hand washing.
Reteplase-induced Hypotension in Patients Undergoing Thrombolysis in Acute Myocardial Infarction- Case Series
Authors: S Arun , Gudge Rahul , Lal Hina , Vartha Shoban Babu , Ambwani Sneha , Deora Surender , singh Surjit
Published: February 2024

Introduction:
Reteplase is the second-generation tissue plasminogen activator used as a thrombolytic agent for myocardial infarction patients. It has better tolerability as compared to streptokinase. Bleeding is one of the recorded side effects of reteplase.
Case presentation:
In this case, a series of 2 patients noticed an incidence of hypotension after the infusion of the Reteplase with an average onset in 20- 30 minutes after the first dose of Reteplase. Of the two patients encountered with the event of hypotension secondary to Reteplase, a 68-year-old male was diagnosed with anterior wall MI, and a second patient of age 55 years old, was diagnosed with anterolateral wall MI. Reteplase-induced hypotension is relatively uncommon in the literature and documented reports. All patients recovered in the period.
Conclusion:
Two patients encountered hypotension after the infusion of Reteplase can come under “Possible” adverse drug reaction according to the WHO causality assessment. The possible mechanism of action for the incidence of hypotension post-thrombolysis or during thrombolysis may be assigned to releasing the inflammatory mediators secondary to the hypersensitivity reaction. Both Patients recovered with the symptomatic therapy.