bluuebunny/crossref_metadata_2025 huggingface dataset:
Notas sobre el antiguo Derecho agrario: el contrato de menseguería de la comarca de Priego en el siglo XVII
Authors: PELAEZ DEL ROSAL MANUEL
Published: January 2024

Estudio histórico y jurídico del contrato de menseguería en la localidad de Priego de Córdoba, frecuentemente utilizado en el siglo XVII
Un crimen en el barrio de la Ajerquía en la Córdoba del siglo XI
Authors: Arjona Castro Antonio
Published: January 2024

Estudio histórico de un caso criminal en la Córdoba musulmana del siglo XI
Dos caras de Andalucía durante el siglo XIX: la Constitución de Antequera de 1883, entre realidad y proyecto
Authors: Morán Martín Remedios
Published: January 2024

Análisis histórico y crítico de la Constitución de Antquera de 1883
Eduardo de Hinojosa, precursor científico de la historiografía jurídica (1852-1919)
Authors: Hurtado de Molina Julián
Published: January 2024

Estudio biográfico de Eduardo de Hinojosa
Del Concordato de 1851al de 1953: Estatus jurídico administrativo de la Iglesia Española
Authors: Sánchez Garrido Alfonso
Published: January 2024

Estudio histórico del régimen de concordato de la Iglesia con el reino de España
Algunas reflexiones en torno al tribunal de garantías constitucionales de la Segunda República
Authors: García-Cuevas Roque Elena
Published: January 2024

Estudio histórico y crítico del Tribunal de Garantías Constitucionales durante la vigencia de la Segunda República
La monarquía en España de 1939 a 1975
Authors: PEÑA GONZÁLEZ JOSÉ
Published: January 2024

Estudio histórico-jurídico de la situación de la monarquía durante el régimen franquista
Instituciones y Política. Una aproximación al estudio del poder en la Administración Provincial en la segunda mitad del siglo XX
Authors: Martínez Hernández CARMEN
Published: January 2024

Estudio crítico e institucional de la Administración provincial en la segunda mitad del siglo XX
La valoración de bienes heredados sujetos a colación. Un pleito en el Juzgado de Posadas
Authors: GONZÁLEZ PORRAS JOSÉ MANUEL
Published: January 2024

En el presente trabajo me ocupo de analizar por su importancia no solamente doctrinal, con opiniones contrarias, sino por su trascendencia práctica, y que es la determinación del momento en el que debe tener lugar la valoración de los bienes que se reciben por vía sucesoria y sujetos a colación
«Calle cronista Rey Díaz»: Razones para mantener su nombre y comentario a la sentencia que así lo declaró
Authors: PELAEZ DEL ROSAL MANUEL
Published: January 2024

El 25 de junio de 1965 el ayuntamiento de Córdoba, en sesión plenaria, acordó por unanimidad rotular en el Barrio de Santa Rosa una calle al cronista dela ciudad don José María Rey Díaz1, con el nombre de «Cronista Rey Díaz», fallecido dos años antes, cuando tenía 71 de edad. Se tributaba de esta justa forma, podría parecerlo, pero no era así, un rendido recuerdo para el futuro a quien desde 1922 había desempeñado fecundamente este cargo honorífico, ignorándose en aquellas calendas que otro ayuntamiento, el de 2018, en sesión ordinaria de 13 de febrero, adoptase el acuerdo de su despojo, ciertamente por una victoria pírrica, a saber por mayoría de 15 votos.
Tipificación de los delitos contra el derecho de gentes en la codificación española
Authors: PINO ABAD MIGUEL
Published: January 2024

Nuestros Códigos penales decimonónicos fueron pioneros en la tipificación de los atentados perpetrados contra los monarcas o representantes de otras naciones que se hallasen oficialmente en España, sus inmunidades y domicilios. Ese hecho provocó encendidos enfrentamientos en las Cortes durante la discusión del Proyecto de 1821, que desembocó en el Código de 1822. Un elevado número de diputados no entendía como se estaba concediendo una especial protección a esos representantes extranjeros cuando no existía reciprocidad para los nuestros cuando se encontraban en el exterior. Décadas más tarde, los principales comentaristas del Código penal de 1848 siguieron insistiendo en la misma idea. Pese a todas esas críticas, nuestros primeros códigos allanaron el camino y permitieron que el de 1870 se convirtiera en referente para otros textos internacionales de su época
Antonio Jaén Morente y José María Rey Díaz en la Comisión Provincial de Monumentos de Córdoba (1930-1936)
Authors: TORIBIO GARCIA MANUEL
Published: January 2024

La Comisión Central y las Provinciales de Monumentos fueron creadas en 1844 para proteger los edificios y objetos de arte que habían pasado a ser propiedad del Estado tras las medidas desamortizadoras tomadas años atrás. Eran como agentes directos del Estado en conexión con el Gobernador Civil. En 1847 pasan a depender de la Academia de San Fernando. Inspeccionan los museos públicos y velan por la conservación y restauración de los monumentos artísticos. Crearon museos de bellas artes y arqueológicos, hicieron catálogos provinciales y otros trabajos de investigación. Pero su objetivo era evitar que se derribaran edificios de valor artístico, conservar y restaurar las obras de arte y los documentos de archivos
Uso de los métodos de diagnóstico de relación esquelética en los artículos publicados del 2018 al 2020 en las cuatro revistas más importantes de ortodoncia
Authors:   , De los Rios Fernandez Enrique Manuel
Published: January 2024

Objetivo: Determinar el método de diagnóstico de relación esquelética más empleado, según las cuatro revistas más importantes de ortodoncia en el periodo 2018-2020. Metodología: Se elaboró un análisis documental de información compilada ya existente referida a los procedimientos de diagnóstico utilizados con mayor frecuencia en el reconocimiento de las relaciones esqueléticas en las cuatro revistas más importantes de ortodoncia desde el año 2018 hasta el 2020, según SCImago 2018, cuyo soporte en internet proporciona una serie de parámetros acerca del impacto de las publicaciones y revistas. Con esa finalidad, se realizó una sinopsis de la información analizada para establecer una correlación de las fuentes y hacer cotejos entre ellas de manera crítica. La exploración bibliográfica virtual de bases de datos se realizó esencialmente a través de Medline; se evaluó y seleccionó la bibliografía, organizada según la trascendencia y la índole científica; y, luego, se procesaron los resultados para responder las demandas de la investigación. Resultados: En la revista AJO-DO, el 92,2% utiliza el método de ANB y el 7,8% no describe el método utilizado. En la revista AO, el 100% refiere el uso del ANB. Finalmente, en las revistas EJO y KJO, el 93,8 % y el 95% utilizaron el ANB, respectivamente. Conclusión: El método más frecuentemente utilizado para la determinación de la relación esquelética es el ANB, aun cuando este indicador presenta un riesgo de efecto geométrico, ya que es un método ampliamente conocido.
Complejidad de cirugías en terceros molares mandibulares según índice de Pederson: Un estudio radiológico en muestra peruana
Authors:   , Flores Diaz Kimberly Lisset
Published: January 2024

Objetivo: El estudio tuvo como objetivo determinar la frecuencia de complejidad en cirugías de terceros molares mandibulares (TMM) según el índice de Pederson en un estudio radiológico de una muestra peruana. Materiales y métodos: La muestra se conformó de 235 TMM presentes en 120 radiografías panorámicas digitales de pacientes de 16 a 55 años de un hospital público de Lima en el año 2019. Los datos recolectados fueron el sexo, la edad, la posición del diente, la relación espacial, la profundidad, la relación con la rama ascendente, y el índice de Pederson. Resultados: Los TMM mostraron una prevalencia de complejidad quirúrgica moderadamente difícil (53,6 %) con índice de Pederson (5 [5-6]), impactación mesioangular (46,4 %), profundidad A oclusal alta (46,8 %), y relación con la rama clase II reducida (76,2 %). Un mayor índice de Pederson se asoció a más edad, pero no al sexo ni posición. Las mujeres presentaron más distoangulación y relación clase II, los varones más posición horizontal y relación clase I, y una mayor edad se asoció a relación clase III (P<0,05). Conclusión: La subpoblación peruana mostró TMM con una complejidad quirúrgica moderadamente difícil asociada a una mayor edad, mesioangulación, profundidad oclusal alta, y espacio retromolar insuficiente.
Análisis comparativo del nivel de toxicidad de las técnicas de incineración y la técnica de relleno sanitario para la eliminación de residuos sólidos en los hospitales José Agurto Tello de Chosica y el María Auxiliadora de San Juan De Miraflores
Authors:   , Arestegui Chavez Joanna Claudia
Published: January 2024

La investigación comprendió como objetivo un análisis del grado de toxicidad de las técnicas de incineración y relleno sanitario de las emisiones del Hospital María Auxiliadora y el Hospital José Agurto Tello con la finalidad de comparar los impactos ambientales que produce cada técnica de eliminación. Por lo tanto, se aplicó una metodología descriptiva no experimental. Los resultados revelaron que las emisiones hospitalarias bajo la técnica de incineración incluyeron Monóxido de Carbono (CO), Óxidos de Nitrógeno (NOx), y Dióxido de Azufre (S02) adquiridos en la base de la estación EM-01 presentan valores inferiores a los Límites Máximos Permisibles en ambos centros médicos. Por otro lado, el nivel de toxicidad del desecho hospitalario bajo la técnica de relleno sanitario demostró que las cantidades de PM10 derivadas de las estaciones de monitoreo presentan valores inferiores a los Estándares de Calidad Ambiental (ECA) para 24 horas. Se llegó a concluir que el grado de toxicidad del método de incineración en el Hospital María Auxiliadora fue superior en comparación con el método de relleno sanitario de los residuos generados en Hospital José Agurto Tello, no obstante, ambas condiciones presentaron valores inferiores de los valores establecidos en la norma en el Decreto Supremo N°003-2017-MINAM.
Estudio in vitro del efecto bactericida de Verbena litoralis (Verbena) frente a cepas de Klebsiella pneumoniae ATCC 27853 y Escherichia coli ATCC 25922
Authors:   , Roque Rodriguez Axel Sergio , Serna Huaman Adriel Antonio
Published: January 2024

La siguiente investigación tiene como objetivo evaluar el efecto bactericida de la Verbena litoralis (Verbena) en las cepas de Klebsiella pneumoniae ATCC 27853 y Escherichia coli ATCC 25922 utilizando un diseño de estudio experimental In vitro, realizado en los laboratorios de la Universidad Científica del Sur. Metodología: La Verbena litoralis fue preparada mediante técnicas de extracción hidroalcohólica, de las cuales se hizo un ensayo fitoquímico y una prueba de actividad antimicrobiana. Se obtuvieron la Concentración Mínima Inhibitoria (CMI) y la Concentración Mínima Bactericida (CMB). Los agentes bacterianos utilizados fueron brindados por el Laboratorio de Microbiología Molecular y Genómica Bacteriana de la Universidad Científica del Sur. Resultados: Se hallaron en el extracto hidroalcohólico compuestos bioactivos como: aminoácidos libres, péptidos, proteínas, fenoles, flavonoides, quinonas, antocianidina, lípidos, entre otros. La CMI de la resina de Verbena litoralis, fue de 100 mg/mL frente a Klebsiella pneumoniae y Escherichia coli; por otro lado, la CMB fue de 400 mg/mL y 200 mg/mL frente a Klebsiella pneumoniae y Escherichia coli, respectivamente. Conclusiones: La resina derivada del extracto hidroalcohólico de la Verbena litoralis tiene actividad bactericida frente a K. pneumoniae ATCC 27853 y E. coli ATCC 25922, demostrando un grado diferente de susceptibilidad frente a bacterias gram negativas.
Comparación de matriz de colágeno xenogénica e injerto de tejido conectivo para el tratamiento de recesiones gingivales múltiples: una revisión sistemática
Authors:   , Orellano Merluzzi Ariana Alejandra , Zegarra Caceres Lorena Alejandra
Published: January 2024

Objetivos: Esta revisión sistemática (RS) evaluó el efecto de la matriz de colágeno xenogénica (MCX) versus el injerto de tejido conectivo (ITC) para el tratamiento de las recesiones gingivales múltiples (RGM) Miller Clase I y II o Cairo tipo I. Materiales y métodos: Se realizaron búsquedas en cinco bases de datos hasta agosto de 2022 para encontrar ensayos clínicos aleatorizados (ECAs) que compararon los efectos clínicos de la MCX frente al ITC en el tratamiento de las RGM. Se utilizó un modelo de efectos aleatorios de diferencias de medias para determinar la reducción de la recesión gingival (RG), la ganancia del ancho de tejido queratinizado (ATQ), la ganancia en la espesura gingival (EG) y la ganancia del nivel de inserción clínica (NIC). Se utilizó la razón de riesgo para el recubrimiento radicular completo (RRC) a los 6 y 12 meses. Resultados: En esta RS se incluyeron 10 ECAs que representaron 1095 y 649 RGs a los 6 y 12 meses. El metanálisis no mostró diferencias estadísticamente significativas en la reducción de la RG, la ganancia del ATQ, la ganancia de EG y la ganancia del NIC entre los grupos a los 6 meses (p>0,05). Sin embargo, a los 12 meses de seguimiento mostró diferencias a favor del grupo control (p<0,05). El RRC fue significativamente mayor en el grupo de ITC a los 6 y 12 meses (p<0,05). En cuanto a la hipersensibilidad dentinaria (HD) no se encontraron diferencias estadísticamente significativas entre los grupos a los 6 y 12 meses de seguimiento (p<0,05). Conclusiones: A los 12 meses, el ITC mostró resultados clínicos significativamente superiores en el tratamiento de las RGM; sin embargo, esta diferencia no se observó en la disminución de la HD.
Interacción farmacológica entre el extracto de Blechnum asplenioides Sw. "Cuti cuti" y fármaco hipoglicemiante metformina en ratas albinas hiperglucémicas
Authors:   , Solano Garay Giancarlo Jesus , Suarez Hernandez Thalia Camila
Published: January 2024

ANTECEDENTES: En el territorio peruano, se conocen varias especies de plantas con el nombre común de "Cuti cuti". Estas plantas se han destacado por sus numerosas propiedades medicinales. Sin embargo, en el caso de la especie Blechnum asplenioides "cuti cuti", aún no se ha demostrado su propiedad hipoglucemiante ni su interacción con fármacos hipoglucemiantes como la metformina. OBJETIVOS: Determinar la interacción farmacológica entre el extracto de Blechnum asplenioides Sw “cuti cuti” con la metformina en ratas albinas hiperglucémicas por aloxano. MÉTODOS: Se utilizaron 72 ratas albinas macho con hiperglucemia inducida por aloxano (180 mg/kg) vía intraperitoneal; asignados al azar en 9 grupos experimentales, a los cuales se les administró el extracto hidroalcohólico de Blechnum asplenioides Sw. “cuti cuti”, obtenido de las hojas secas de la planta recolectada de San Ignacio - Cajamarca, Perú, a dosis de 250 y 500 mg/kg y Metformina a dosis de 100 y 200 mg/kg según el grupo experimental designado. Para monitorizar el efecto de la interacción se midió la glucemia pre aloxano, post aloxano, 1, 2, 6 y 24 horas posteriores a la intervención. RESULTADOS: En el estudio fitoquímico realizado en Blechnum asplenioides Sw. “cuti cuti” se identificaron alcaloides, flavonoides, compuestos fenólicos, triterpenos, esteroides y saponinas. Durante el estudio se observó el mayor efecto hipoglucémico en el grupo tratado con Blechnum asplenioides Sw. “cuti cuti” a dosis de 250 mg a las 1 y 2 horas, y en el grupo tratado con Blechnum asplenioides Sw. “cuti cuti” a dosis de 250 mg/kg y metformina a dosis de 100 mg/kg a las 6 horas. A las 24 horas, se registraron los valores más bajos de glucemia en el grupo tratado con Blechnum asplenioides Sw. “cuti cuti” a dosis de 250...
Concordancia del biotipo facial según el análisis cefalométrico del polígono de Björk-Jarabak con el análisis fotográfico del ángulo de apertura facial en individuos peruanos
Authors:   , Medina Grandez Ana Flavia , Llontop Palma Luciana
Published: January 2024

Antecedentes: El análisis del biotipo facial puede brindar información útil para el diagnóstico de ortodoncia y puede determinar el tipo de crecimiento de un paciente para orientar el tratamiento de ortodoncia. El objetivo de este estudio fue determinar la concordancia del biotipo facial según análisis cefalométrico de Björk-Jarabak y análisis fotográfico del ángulo de apertura facial en individuos peruanos. Materiales y métodos: Este estudio retrospectivo incluyó 244 radiografías cefalométricas y fotografías frontales de los mismos pacientes obtenidas de una base de datos. El biotipo facial (mesofacial, braquifacial o dolicofacial) se determinó con el polígono de Björk-Jarabak (cefalométrico) y el ángulo de apertura facial (fotográfico). Dos investigadores capacitados realizaron todas las mediciones. La concordancia del diagnóstico facial se determinó mediante correlaciones del coeficiente interclase y el test de kappa. p<0,05. Resultados: En los casos con biotipo mesofacial, ambos análisis coincidieron en 60 individuos (68,2%), mientras que en los diagnosticados con biotipo dolicofacial, los análisis solo coincidieron en 17 individuos (10,4%). No hubo concordancia entre los dos métodos en cuanto al biotipo braquifacial ya que según el ángulo de apertura facial ninguno de los individuos presentó biotipo braquifacial (test de kappa ponderado= 0,020, p=0,586). Conclusión: Los análisis cefalométrico y fotográfico deben ser complementarios y uno no debe sustituir al otro. La atención debe centrarse en los biotipos dolicofacial y braquifacial, que mostraron menor concordancia entre las evaluaciones. Por lo que se necesitan más estudios para seguir esta línea de investigación.
Carbon and nitrogen nutrient analysis of eucalyptus leaves
Authors: Younes Nicolas , Cain Sophia
Published: January 2024

This protocol aims to record total carbon and nitrogen as a percentage of total leaf mass using combustion analysis. The protocol uses ground leaf material and has been tested on a variety of shrub and tree species. The protocol is straightforward and easy to complete once trained in the use of the applicable combustion analyser. Depending on the type of columns in the combustion analyser, carbon can consume some components readily increasing the frequency of column replacement which can increase the time taken and cost to complete this method. The key steps of this method including grinding the dried plant material down to consistent size, for example 1 mm, and then analysing the samples using a combustion analyser. Grinding can take up to three hours for 40 samples and weighing samples for, and running, the analyser can take 7-8 hours.
Cellulose extraction and quantification from eucalyptus leaves in the laboratory
Authors: Cain Sophia , Younes Nicolas
Published: January 2024

This protocol aims to extract cellulose from plant material using a nitric acid digestion and quantification using spectrophotometry. This protocol has been modified from existing protocols so that extraction of cellulose can be performed in 2 mL microcentrifuge tubes using ground plant material as the starting product. Key stages of the procedure include the nitric acid digestion and removal of breakdown products where approximately 100 samples can be digested in a day. The procedure is concluded with a conversion of cellulose to glucose, and finally quantification using spectrophotometry where approximately 200 samples can be quantified in a day.
Integrated molecular portraits of breast cancer
Authors: Jiang Yi-Zhou , Ma Ding , Jin Xi , Xiao Yi , Yu Ying , Shi Jinxiu , Zhou Yi-Fan , Fu Tong , Lin Cai-Jin , Dai Lei-Jie , Liu Cheng-Lin , Zhao Shen , Su Guan-Hua , Hou Wanwan , Liu Yaqing , Chen Qingwang , Yang Jingcheng , Zhang Naixin , Zhang Wen-Juan , Liu Wei , Ge Weigang , Yang Wen-Tao , You Chao , Gu Yajia , Kaklamani Virginia , Bertucci François , Verschraegen Claire , Daemen Anneleen , Shah Nakul M. , Wang Ting , Guo Tiannan , Shi Leming , Perou Charles M. , Zheng Yuanting , Huang Wei , Shao Zhi-Ming
Published: January 2024

The associated article reports multiomic analysis of breast cancers, where we provided a unique public resource that contributes novel insights into the breast cancer, holding promise for further precision treatment approaches. This protocol not only delineates detailed experimental procedures for sample preparation and data generation but also comprehensive analysis methods for genomics, transcriptomics, proteomics, and metabolomics from breast cancer samples. Furthermore, regarding radiomics and pathomics, the protocol describes the extraction of both radiological and pathological features in detail.
Advanced microfluidic tool for rapid buffer exchange and in situ imaging of phase separation in immobilized giant unilamellar vesicles
Authors: Cochereau Rémy , Voisin Hugo , Davy Joëlle , Jamme Frédéric , Renard Denis , Boire Adeline
Published: January 2024

Semi-permeable Giant Unilamellar Vesicles (GUVs) are powerful tools for studying macromolecular assembly, notably liquid-liquid phase separation (LLPS). Here, we present a microfluidic protocol for GUVs production, immobilization and rapid buffer exchange. It enables real-time imaging of phase separation within isolated GUVs with various microscopy technics (optical, confocal and UV-autofluorescence). The principle of this device is based on the production of water-in-oil-in-water double emulsion droplets and their turning into GUVs by elimination of their oil phase. The immobilization of GUVs is provided by physical and chemical traps, using the strong biotin-streptavidin affinity. These vesicles become semi-permeable to small molecules (< 2000 g/mol) viathe α-hemolysin pore protein. Within minutes, the internal GUV phase can be changed using different external buffers. This provides a way to induce the assembly of macromolecules and monitor overtime the dynamic of phase separation. In particular, we show, on a specific example, the occurrence of LLPS through both nucleation and growth and spinodal decomposition. The protocol can be divided into two distinct phases: (1) the chip fabrication spans approximately two days but yields approximately 10 chips, and (2) the GUV production, immobilization, and buffer exchange, can be completed in just half an hour. This microfluidic tool represents a significant advance by offering a faster and more controlled buffer exchange as compared to alternative methods. It opens new routes to investigate the dynamics of macromolecular assembly, particularly in the context of LLPS.
The Face-in-the-Crowd attentional bias modification task improves mood but not through modified attentional biases: a randomised experimental trial.
Authors: Skvarc David R. , Hyder Shannon , Hayley Alexa
Published: January 2024

Attentional and cognitive biases related to psychological distress have been modified in clinical samples. This study investigates whether such biases can be detected and changed in a community sample and whether such training can reduce psychological distress. Participants were randomly assigned to an experimental or control condition and assessed at baseline, seven days, and 30 days follow-up. We operationalised attentional biases as target search latency in milliseconds. Results showed limited evidence of attentional biases in participants with higher trait mood distress. However, significant correlations were found in the experimental condition at day thirty, indicating a relationship between task latency and stress, as well as changes in latency and depression. Curiously, we observed some evidence of improvement in mood after the intervention. Participants in the control condition reported the greatest improvements in mood and psychological distress, while effects in the experimental condition were largely changes in attentional biases. These findings suggest that while attentional biases associated with psychological distress are obscured in community samples, the use of a bias modification intervention can be effective in eliciting a positive bias which, in turn, improves mood. This study highlights the potential for attentional bias modification in treating psychological distress symptoms.
Immuno-modulatory Effects of a Herbo-mineral Ayurvedic Formulation in Experimental Models
Authors: Prakash Vaidya , Sati Sneha , Rao Yashwant , Prakash Shikha , Negi Neha
Published: January 2024

Ayurveda, an ancient Indian system of medicine, encapsulates comprehensive principles and formulations for disease prevention and treatment. A herbo-mineral Ayurvedic formulation, IMMBO, comprising Mandoor Bhasma and eighteen herbs has shown promising results in treating Allergic Rhinitis. The said efficacy was recently reinstated by a randomized controlled clinical trial conducted at a reputed hospital and IMMBO significantly reduced the IgE levels and Total nasal symptom scores in treated patients. This article discusses the findings of a series of experimental studies conducted to explore the immuno-modulatory potential of IMMBO. The studies reveal the immunomodulatory effects of IMMBO, evidenced by its effectiveness in reinstating neutrophil activation, stimulating cellular and humoral immunity, and counteracting immunosuppression at the molecular level. The modulation of key signalling molecules, including TNF-α, IFN-γ, IL-1β, ERK, PI3K, and NF-κB, showcases the formulation’s multifaceted impact. Additionally, its ability to block histamine release suggests potential in controlling allergic states, positioning it as a promising therapeutic candidate for immune-related disorders. However, the precise mode of action remains elusive, warranting further in-depth pharmacological studies. This research substantiates the ancient Ayurvedic wisdom using modern scientific parameters, endorsing IMMBO's potential as an immune-modulatory agent.
Unprecedented Direct Methanol Coupling for Selective Conversion of CO2 to Ethane at Room Temperature and Ambient Pressure
Authors: Djire Abdoulaye , Ngozichukwu Bright , Lee Chi Ho , Johnson Denis , Kasten James , Kwon Joseph Sang-II
Published: January 2024

Effective electrocatalysts with high activity and selectivity for carbon dioxide (CO2) reduction to multi-carbon (C2+) products are still lacking. CO dimerization to C2+ products such as ethylene and ethanol can be achieved on Cu-based catalysts, but direct coupling to ethane (C2H6) has not been realized. Here, we show high selectivity of CO2 to C2H6 at room temperature and ambient pressure. Specifically, we report both experimental and theoretical findings for the Ti2N electrocatalyst, that exhibits the highest reported Faradaic efficiency (FE) for C2H6 (~ 46.8%) at a current density of 25 mA cm− 2 and potential of -1.44 V versus the reversible hydrogen electrode (RHE) with ethane energy efficiency of ~ 20%. We achieve this outstanding performance via an alternative reaction pathway, where the *CH3OH adsorbed species are stabilized on the catalyst surface, which facilitates the production of C2H6 through the *CH3OH coupling mechanism as corroborated by density functional theory (DFT). We demonstrate that the high selectivity is accompanied by excellent catalytic, structural, and electronic stability as evidenced by XAS, TEM, FTIR and SEM measurements. These groundbreaking chemistry advancements and catalysts unveil uncharted avenues for converting CO2 into liquid fuels and chemicals.
Enhancing Flood Routing Accuracy: A Fuzzified Approach to Nonlinear Variable-Parameter Muskingum Model
Authors: Aletaha Amirfarhad , Kermani Masoud Reza Hessami , Akbari Reyhaneh
Published: January 2024

Flood routing stands as a critical technique for water engineers in effectively managing and mitigating the consequences of floods. Among the prevalent hydrological methods, the Muskingum method emerges as a highly efficient approach, owing to its accuracy and simplicity in application. This research introduces a novel partitioning framework aimed at refining outcomes from a nonlinear variable-parameter Muskingum model. This improvement is achieved by introducing fuzzification to the boundaries of adjacent sub-periods. The results underscore the efficacy of the proposed method in enhancing the accuracy of routed outflow, aligning well with the inherent characteristics of a flooding event. Validation of the newly introduced fuzzified nonlinear variable-parameter Muskingum model was conducted using four distinct case studies from the literature. These encompassed Wilson's dataset, the flood events in Rivers Wye and Wyre, and Viessman and Lewis' data. The evaluation of the proposed framework's effectiveness utilized metrics such as the Sum of Squared Deviations (SSQ), the Sum of Absolute Deviations (SAD), Mean Absolute Relative Error (MARE), and the Variance Explained in Percentage (VarexQ). The results demonstrated a notable increase in the accuracy of the nonlinear Muskingum model for the respective cases studied. This implies that the proposed partitioning framework is adaptable to various flooding events, irrespective of their intensity and duration, thereby advancing the applicability of any variable-parameter Muskingum model.
Clinical value of measuring plasma D-dimer levels in patients with esophageal cancer
Authors: Chen Hao , Xu Bindong , Zhang Qiang , Chen Pengfei
Published: January 2024

Background
Esophageal cancer represents a significant public health concern; however, reliable diagnostic and prognostic markers have not been established. This study aimed to investigate the clinical value of plasma D-dimer levels in patients with esophageal cancer.
Methods
Overall, 120 patients with esophageal cancer who underwent radical surgical resection at our department between January 2019 and 2020 were included (esophageal cancer group). Plasma D-dimer levels were measured preoperatively and on postoperative days 1 and 14. Additionally, 60 healthy participants (control group) with measured plasma D-dimer levels were included. The preoperative D-dimer levels and positive D-dimer test rates were compared between the groups. The 3-year survival rate in patients with esophageal cancer was calculated using the Kaplan–Meier method.
Results
Preoperative D-dimer concentrations were significantly higher in the esophageal cancer group than in the control group. The positivity rate in the esophageal cancer group (35.0%, 42/120) was significantly higher than that in the control group (15%, 9/60). D-dimer concentrations were significantly higher 1 day postoperatively than preoperatively. Conversely, D-dimer concentrations were significantly lower 14 days postoperatively than preoperatively. Patients in the esophageal cancer group with plasma D-dimer concentrations ≤ 0.5 µg/mL had significantly higher 3-year survival rates than those with higher concentrations. In the logistic multivariate analysis, tumor pathological stage and preoperative plasma D-dimer levels were independent prognostic factors of 3-year survival rates in patients with esophageal cancer.
Conclusion
Plasma D-dimer concentrations are clinically valuable in esophageal cancer diagnosis, postoperative recurrence monitoring, and prognosis prediction.
Clustering induces switching between phoretic and osmotic propulsion in active colloidal rafts
Authors: Tierno Pietro , Boniface Dolachai , Leyva Sergi , Pagonabarraga Ignacio
Published: January 2024

Active particles driven by chemical reactions are the subject of intense research to date due to their rich physics, being intrinsically far from equilibrium, and their multiple technological applications. Recent attention in the field is now shifting towards exploring the fascinating dynamics of mixture of active and passive systems. Here we realize active colloidal rafts, composed of a single catalytic particle encircled by several shells of passive microspheres, and assembled via light activated chemophoresis. We show that the cluster propulsion mechanism switches from diffusiophoretic to
diffusioosmotic by increasing the number of colloidal shells.
Using the Lorenz reciprocal theorem, we demonstrate that in large clusters self-propulsion emerges by considering hydrodynamics via the diffusioosmotic response of the substrate.
The dynamics in our active colloidal rafts
are governed by the interplay between phoretic and osmotic effects. Thus, our work highlights their importance in understanding the rich physics of active catalytic systems.
An Experimental Study on Data Augmentation Techniques for Named Entity Recognition on Low-Resource Domains
Authors: Torres Arthur Elwing , de Moura Edleno Silva , Silva Altigran Soares da , Nascimento Mario A. , Mesquita Filipe
Published: January 2024

Named Entity Recognition (NER) is a machine learning task that traditionally relies on supervised learning and annotated data. Acquiring such data is often a challenge, particularly in specialized fields like medical, legal, and financial sectors. Those are commonly referred to as low-resource domains, which comprise long-tail entities, due to the scarcity of available data. To address this, data augmentation techniques are increasingly being employed to generate additional training instances from the original dataset. In this study, we evaluate the effectiveness of two prominent text augmentation techniques, Mention Replacement and Contextual Word Replacement, on two widely-used NER models, Bi-LSTM+CRF and BERT. We conduct experiments on four datasets from low-resource domains, and we explore the impact of various combinations of training subset sizes and number of augmented examples. We not only confirm that data augmentation is particularly beneficial for smaller datasets, but we also demonstrate that there is no universally optimal number of augmented examples, i.e., NER practitioners must experiment with different quantities in order to fine-tune their projects.
RETRACTED: Research on Graded Diagnosis of Lettuce Water-Nitrogen Stress and Pest Prevention Based on Deep Learning
Authors: Dong Mo , Gao Yang , Fu Dan , Gao Mingze , Yu Guanghao , Zhao Ruohan
Published: January 2024

The authors have requested that this preprint be removed from Research Square.
A common viral illness with uncommon presentation: A Case Series
Authors: Rohila Amit kumar , Sharma Ankur , S Samarth Bhat K , Garg Mahender Kumar , Gupta Ankur
Published: January 2024

Hepatitis A infection usually causes liver dysfunction, jaundice, anorexia, and fever. Shock is not a common presenting feature of Hepatitis A infection. Patients with shock are commonly encountered in emergencies, and establishing the cause and type of shock is essential. Shock is generally classified into hypovolemic, cardiogenic, septic, and obstructive shock. Thorough clinical examination and point-of-care ultrasound help to establish the cause of shock in such patients. We present two cases of short duration of fever and cardiogenic shock presented to the emergency. After further investigation of the cases, both were found positive for anti-hepatitis A (HAV) antibodies.
Association of preptin and glycemic status in individuals with non-alcoholic fatty liver
Authors: S Rooban , A. Arul Senghor K. , M. Vinodhni V. , P Renuka
Published: January 2024

Context: Preptin is a hormone which is co-secreted with insulin and amylin from beta cells of pancreas. Non-alcoholic fatty liver is a disorder in which there's excessive fat accumulation in the liver cells without evidence of alcohol consumption. Both T2DM and NAFLD is associated with various peptide hormone, but the association of preptin with Non-alcoholic fatty liver and it’s different stages is still not clear.
Aim and objective: To determine the level of preptin in T2DM patients with NAFLD and to assess the levels of liver enzymes. To correlate preptin levels with liver enzymes and stages of NAFLD.
Settings and Design: Analytical cross sectional study
Methods and Material: This is an analytical cross sectional study comprising of 64 T2DM patients divided into two groups based on their glycemic controls with HbA1c more than 8%, ALT ≤ 40 IU/L and ALT ≥ 40 IU/L in SRM Medical College Hospital and Research Centre Diabetology OP and MHC in the age group of 35-80.
Statistical analysis used: The data was analysed using statistical package of social service (SPSS 26.0).
Results: Plasma preptin levels are increased in patients with T2DM and NAFLD. The NAFLD score and TyG index showed a positive correlation in participants in group 2. In group 2 patients there is a positive correlation between NAFLD score and AST, ALT, ALP, GGT, while TyG index shows a positive correction with LDL and VLDL in both groups.
Conclusions: Preptin may have a role in the pathophysiology of NAFLD and may be a valuable marker in predicting fibrosis development along with NAFLD score.
Does pain self-efficacy predict outcomes in people with migraine; an exploratory analysis of the CHESS trial
Authors: Hee Siew Wan , Patel Shilpa , Sandhu Harbinder , Matharu Manjit S. , Underwood Martin
Published: January 2024

Background Chronic headache disorders are disabling. The CHESS trial studied the effects of a short non-pharmacological intervention of education with self-management support for people affected by migraine and/or tension type headache for at least 15 days per month for at least three months. There were no statistically significant effects on the Headache Impact Test-6 (HIT-6) at 12-months. However, we observed improvement in pain self-efficacy questionnaire (PSEQ) and short-term HIT-6. We explored the impact of the CHESS intervention on PSEQ, and subsequently, on the HIT-6 and chronic headache quality of life questionnaire (CH-QLQ) at four, eighth and 12 months.Methods We included all 736 participants from the CHESS trial. We used simple linear regression models to explore the change of HIT-6 and CH-QLQ with treatment and PSEQ at baseline (predictor analysis), and the interaction between treatment and baseline PSEQ (moderator analysis). We considered the change of PSEQ from baseline to four months as a mediator in the mediation analysis.Results Baseline PSEQ neither predicted nor moderated outcomes. The prediction effect on change of HIT-6 from baseline to 12 months was 0.01 (95% CI, -0.03 to 0.04) and the interaction (moderation) effect was − 0.07 (95% CI, -0.15 to 0.002). However, the change of PSEQ from baseline to 4-month mediated the HIT-6 (baseline to 8-, and 12-month) and all components of CH-QLQ (baseline to 8-, and 12-month). The CHESS intervention improved the mediated variable, PSEQ, by 2.34 (95% CI, 0.484 to 4.187) units and this corresponds to an increase of 0.21 (95% CI, 0.03 to 0.45) units in HIT-6 at 12-months. The largest mediated effect was observed on the CH-QLQ Emotional Function, an increase of 1.12 (95% CI, 0.22 to 2.20).Conclusions PSEQ was not an effective predictor of outcome. However, change of short-term PSEQ mediated all outcomes, albeit minimally. Future behavioural therapy for chronic migraine may need to consider how to achieve larger, and more sustained increases level of self-efficacy than that achieved within the CHESS trial.Trial registration ISRCTN79708100.
Differentiating Diffuse Electron Scattering in Complex FCC Alloys via Fluctuation and Correlation Mapping
Authors: Krogstad Jessica , Kung Po-Cheng , Zuo Jian-Min , Feng Rui , Liaw Peter
Published: January 2024

Complex face-centered-cubic (FCC) alloys often exhibit chemical short-range ordering (CSRO), detectable by diffuse scattering. However, diffuse scattering can have multiple sources that are challenging to differentiate from CSRO by traditional methods. This led to debates on the origin of diffuse-scattering signals, e.g. at 1/3{422} and 1/2{311} positions. Here, we propose a novel method based on Four-Dimensional Scanning Transmission Electron Microscopy (4D-STEM) to investigate diffuse-scattering signals in complex FCC alloys by fluctuation and correlation analysis. We apply this method to a solution-treated (CrCoNi)93Al4Ti2Nb medium entropy alloy (MEA) and demonstrate the first experimental evidences of diffuse-scattering signals originated from CSRO with directional partial ordering, nanoscale planar defects, and an universal homogeneous source whose signals coincide with planar defects. The principles of the fluctuation and correlation analysis of diffuse scattering are general and applicable to any complex FCC alloy systems, offering valuable insights on the microstructure and CSRO behavior of these materials.
Development of an photoacoustic-based radiomics nomogram to preoperatively predict Ki-67 expression level in patients with breast cancer
Authors: Wang Mengyun , Huang Zhibin , Wu Huaiyu , Mo Sijie , Zheng Jing , Luo Hui , Chen Jing , Tang Shuzhen , Li Guoqiu , Yin Yunqing , Chen Zhijie , Xu Jinfeng , Dong Fajin
Published: January 2024

Objective
This study aimed to develop and validate a radiomic nomogram utilizing photoacoustic imaging to predict Ki-67 status in breast cancer patients.
Methods
A retrospective analysis included 223 breast cancer patients diagnosed between October 2022 and October 2023. Patients underwent multimodal photoacoustic/ultrasound imaging and Ki-67 detection. Random allocation into training (n = 178) and test sets (n = 45) followed an 8:2 ratio. Tumor regions were outlined, and radiomic features were extracted from both photoacoustic and ultrasound images. Feature screening involved independent samples t-tests and the least absolute shrinkage with selection operator (LASSO). Rad-Score was computed for each radiomic score, and logistic regression integrated Rad-Score with clinical risk factors to construct the nomogram. Comparative analysis between nomogram models of the two images was performed. Model performance was assessed using receiver operating characteristic (ROC) curves, decision curve analysis (DCA), and calibration curves.
Results
In both cohorts, the nomogram model outperformed clinical and radiomic models. In the test cohort, the area under the curve (AUC) for photoacoustic and ultrasound-based nomogram models were 0.87 (95% CI: 0.69–0.89) and 0.84 (95% CI: 0.67–0.86), respectively, indicating superior performance of the photoacoustic-based nomogram in predicting Ki-67 expression. DCA further demonstrated the clinical utility of the model.
Conclusions
The nomogram model based on photoacoustic radiomics shows promise as a potential tool for predicting Ki-67 levels in breast cancer.
Previously hidden landslide processes revealed using distributed acoustic sensing with nanostrain-rate sensitivity
Authors: Ouellet Susanne , Dettmer Jan , Lato Matthew , Cole Steve , Hutchinson D. , Karrenbach Martin , Dashwood Ben , Chambers Jonathan , Crickmore Roger
Published: January 2024

Landslides can sometimes creep for decades before undergoing runaway acceleration and experiencing catastrophic failure. Observing and monitoring the evolution of strain in time and space is crucial to understand landslide processes, including the transition from slow to fast movement. However, the limited spatial or temporal resolution of existing landslide monitoring instrumentation limits the study of these processes. We present a method employing distributed acoustic sensing (DAS) strain data below 1 Hertz frequency over a three-day period of rainfall and quantify strain-rate changes at meter and sub-minute scales. The results reveal rainfall-triggered landslide processes, beginning with the onset of near-surface strain changes at the head scarp. Strain acceleration at a developing rupture zone, retrogression towards the scarp and flow-lobe activity is observed as the rainfall continues. The DAS-inferred processes with displacements of less than 0.5 mm are undetected using other landslide monitoring techniques. Our method illuminates landslide processes occurring with nanostrain-rate sensitivity at spatiotemporal resolution previously not possible.
The Investigation of Somatostatin Receptors as a Potential Target in Breast Phyllodes Tumours
Authors: Mickler Hande Süer , Erkan Murat Mert
Published: January 2024

Somatostatin receptors (SSTRs) constitute a family of G protein-coupled receptors that modulate hormonal secretion and regulate cell proliferation and apoptosis upon binding with somatostatin or its synthetic analogues. SSTRs are expressed in most neuroendocrine neoplasms, particularly in gastroenteropancreatic neuroendocrine tumours, and have been utilized as diagnostic markers as well as therapeutic targets. The radioiodinated somatostatin analogue 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid- Tyr3-octreotate (DOTATATE) has been employed for SSTR-targeting for either diagnostic or therapeutic purposes depending on the labelling with 68Gallium or 177Lutetium, respectively.
SSTR expression is reported in a subset of breast adenocarcinoma and breast neuroendocrine carcinomas; however, minimal knowledge exists regarding their expression in fibroepithelial (biphasic) breast lesions such as fibroadenoma and phyllodes tumours. Aggressive ends of the spectrum, i.e. “cystosarcoma phyllodes” may present a management challenge with recurrences and metastases. In this exploratory study, we investigated both gene and protein expression of SSTR in fibroepithelial lesions of the breast. Our findings reveal that both fibroadenoma and phyllodes tumours express SSTRs. Immunohistochemical analyses suggested that this expression is in the stromal, not epithelial, component by demonstrating that SSTR is predominantly expressed in the areas overlapping with α-smooth muscle actin-positive myoepithelial cells around blood vessels and capillary structures. This study is the first in the literature to demonstrate SSTR positivity in mammary fibroepithelial neoplasms., In a patient undergoing a gallium scan, which is widely used in clinical practice, if a positive lesion is discovered in the breast, the possibility of a fibroadenoma or phyllodes tumour needs to be considered. Once validated, these findings may also have significant implications for the management of these tumours.
Apolipoprotein-A1 transports and regulates MMP2 in the blood
Authors: Sarker Hassan , Panigrahi Rashmi , Lopez-Campistrous Ana , McMuellen Todd , Reyes Ken , Anderson Elena , Krishnan Vidhya , Hernandez-Anzaldo Samuel , Glover J N Mark , Hardy Eugenio , Fernandez-Patron Carlos
Published: January 2024

Synthesized in the liver and intestines, apolipoprotein A1 (ApoA1) is the major protein component of high-density lipoprotein (HDL) particles and transports cholesterol from peripheral organs to the liver. This interorgan communication strategy may protect against atherogenesis by sequestering cholesterol from atherosclerotic lesions. Here, we found that ApoA1 has high affinity for the catalytic groove and fibronectin-like repeats of matrix metalloproteinase 2 (MMP2), the most abundant MMP in human blood. In healthy humans and ApoA1-expressing mice, we found that MMP2 is associated with ApoA1 in HDL. We confirmed the ApoA1/MMP2 interactions using five orthogonal interaction proteomics assays. Strikingly, we found that Apoa1 can allosterically increase the proteolytic activity of MMP2—an effect not observed in ApoA1-deficient plasma from ApoA1 KO mice. This finding was not predictable, as MMP2 was not previously known to be an allosteric enzyme. Using a high-confidence artificial intelligence (AlfaFold)-based structural model of the ApoA1/MMP2 complex, we explain how ApoA1 binds and allosterically regulates MMP2. We suggest that ApoA1 sequesters MMP2 in the blood circulation and redistributes it to ApoA1 target organs, such as the liver. This interorgan communication mechanism is independent of canonical reverse cholesterol transport by ApoA1/HDL and may prevent MMP2-mediated rupture of atherosclerotic plaques. Graphical Abstract