bluuebunny/crossref_metadata_2025 huggingface dataset:
DIFERENSIASI KONSEPTUAL DAN PRAKTIS PENDIDIKAN ISLAM, PENDIDIKAN ISLAMI DAN PENDIDIKAN AGAMA ISLAM
Authors: Faqihuddin Achmad , Romadhon Fajar
Published: March 2024

AbstactThis study aims to analyze the conceptual and practical distinctions among Islamic Education, Islamic Pedagogy, and Islamic Religious Education. Employing a qualitative approach and a comparative study design, data were gathered through in-depth interviews with education practitioners, literature review, and direct observation of the learning process in selected educational institutions in Indonesia. The research sample was purposively chosen to encompass a representative range of institutions implementing these three educational approaches. The findings highlight significant conceptual variances: Islamic Education encompasses a broad spectrum of education grounded in Islamic values; Islamic Pedagogy emphasizes the integration of character education and morality within the curriculum; while Islamic Religious Education focuses on imparting knowledge of Islamic religious beliefs. It is anticipated that this research will enrich the Islamic education literature by elucidating the distinctions among these three educational paradigms and their implications for the formulation of education policies, curricula, and pedagogical practices in Islamic educational institutions.Keywords: Islamic Education, Islamic Pedagogy, Islamic Religious Education, Concept of Islamic Education, Islamic Education Paradigm.AbstrakPenelitian ini bertujuan untuk menganalisis perbedaan konseptual dan praktis antara Pendidikan Islam, Pendidikan Islami, dan Pendidikan Agama Islam. Melalui pendekatan kualitatif dan desain studi komparatif, penelitian ini mengumpulkan data melalui wawancara mendalam dengan praktisi pendidikan, studi pustaka, serta observasi langsung pada proses pembelajaran di lembaga pendidikan yang terpilih di Indonesia. Sampel penelitian dipilih secara purposive untuk mendapatkan variasi representatif dari lembaga yang menerapkan ketiga pendekatan pendidikan tersebut. Hasil penelitian mengidentifikasi perbedaan konseptual yang signifikan antara Pendidikan Islam, yang mencakup aspek luas pendidikan berdasarkan nilai-nilai Islam; Pendidikan Islami, yang lebih fokus pada integrasi pendidikan karakter dan moralitas dalam kurikulum; dan Pendidikan Agama Islam, yang terfokus pada pengajaran aspek keagamaan Islam. Penelitian ini diharapkan dapat berkontribusi pada literatur pendidikan Islam dengan menyediakan pemahaman yang lebih jelas tentang diferensiasi antara ketiga pendekatan pendidikan ini dan implikasinya terhadap pengembangan kebijakan pendidikan, kurikulum, dan praktik pengajaran di lembaga pendidikan Islam. Kata Kunci: Pendidikan Islam, Pendidikan Islami, Pendidikan Agama Islam, Konsep Pendidikan Islam, Paradigma Pendidikan Islam
A Meta-Analysis of Essential Trace Elements in Patients with Coronary Heart Disease
Authors:   Department of Medical Education, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000, Kuala Lumpur, Malaysia
Published: March 2024

There is growing evidence that presence of essential trace elements that pose risk for coronary heart disease (CHD) patients. A meta-analysis was conducted on the levels of trace elements Copper (Cu), Zinc (Zn), Iron (Fe), Manganese (Mn), Cobalt (Co) and Chromium (Cr) in CHD patients. Eligible articles from the databases of Web of Science, Scopus, PubMed, EBSCOHost and Ovid were searched based on PRISMA guidelines. English articles published between 2011 to 2021 were included and analysed by descriptive statistics and RevMan 5.4. Quality assessment was assessed with Newcastle-Ottawa scale. There were six studies selected with 322 participants’ data. Trace elements Cu (SMD=-0.13, 95%CI=[-0.99, 0.73], I2=92%, p=0.77), Zn (SMD=-0.38, 95%CI=[-0.81, 0.06], I2=71%, p=0.09), Fe (SMD=0.47, 95%CI=[-1.19, 2.13], I2=97%, p=0.58) and Mn (SMD=0.11, 95%CI=[-0.11, 0.33], I2=0%, p=0.33) levels were not significant. Sensitivity analysis revealed significant Cu level among patients with CHD (SMD=-0.54, 95%CI=[-0.85, -0.22], I2=0%, p=0.0008) and Fe level among the controls (SMD=1.41, 95%CI=[0.08, 2.73], I2=95%, p=0.04). Whereas Co and Cr levels varied according to dietary and smoking behaviours. Overall quality assessment was medium-to-high quality. Elements Cu was found significant in CHD patients and Fe was found significant among the controls, while other findings were inconclusive.
Effect of Caffeic Acid Phenethyl Ester on Wound Healing: A Systematic Review
Authors:   Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia.
Published: March 2024

Caffeic acid, a naturally occurring organic compound, possesses antioxidant and anti-inflammatory properties, along with its derivatives. This systematic review aimed to evaluate the effect of caffeic acid and its derivatives on oxidative stress and inflammatory response in cutaneous wound healing. This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Searches were performed in PubMed, Scopus, and Ovid MEDLINE. Articles published between 2000 and June 2022, with seven articles meeting the inclusion criteria were retrieved. The articles constituted in-vivo studies that utilised caffeic acid phenethyl ester (CAPE) as the therapeutic agent in three types of cutaneous wound including full-thickness burn injury (n=4), two incisional wounds, and one pressure ulcer. CAPE scavenged reactive oxidative species and reduced lipid peroxidation, superoxide dismutase, nitrotyrosine, malondialdehyde, catalase, xanthine oxidase, and nitric oxide levels. The treated injured area revealed enhanced granulation tissue formation, vascularisation, and collagenisation as well as long-term effects of CAPE as evidenced by reduced myofibroblast amount, CD68-positive macrophages, and increased collagen deposition. The systematic review emphasised how antioxidant and anti-inflammatory effects of CAPE could improve the process of wound healing, suggesting its substantial potential for clinical applications in this domain.
Link of Serum Esterase Enzymes with Cognitive Impairment in Diabetic Patients
Authors:   Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, 5618953141 Ardabil, Iran.
Published: March 2024

Cognitive impairment is one of the main complications of diabetes and patients with cognitive impairment are considered to be in an intermediate stage of decreased cognition with higher risk of developing dementia and Alzheimer's disease. This study aimed at evaluating serum activity of two esterase enzymes including cholinesterase and paraoxonase 1 (PON 1) in diabetic patients and association with cognitive performance and metabolic parameters. In this crosssectional study, 128 diabetic patients were enrolled. Cognitive performance was evaluated using the Wechsler Adult Intelligence Scale-Revised (WAIS-R). Body mass index, fasting blood glucose, fasting blood insulin, insulin resistance, serum cholinesterase and paraoxonase 1 activity were measured. Prevalence of cognitive impairment was found to be 77% in the study population. Serum cholinesterase activity was found to be higher in diabetic patients with cognitive impairment than the patients with normal cognitive performance (p < 0.04). Further, a negative correlation was found between cognitive performance and cholinesterase activity, albeit statistically non-significant. Alteration in the activity of cholinesterase enzyme was shown to be associated with cognitive impairment in diabetic patients and future studies are required to find the pathophysiological mechanisms of diabetic cognitive dysfunction.
Moral Internalisation Influences the Attentional Bias to Smoking and Non-Smoking Stimuli in Malaysian Youth
Authors:   Department of Neurosciences, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian Kelantan Malaysia.
Published: March 2024

The youth age group is a phase of life associated with risk-taking behaviour and challenging moral issues. This study aimed to provide electrophysiological evidence that could explain the interaction between attentional bias towards the health-risk of smoking and non-health risk behaviour stimuli as influenced by various levels of moral identity. Seventy eight eligible subjects (mean age of 22 + 2.1 years old) participated in the event-related potential session. Attentional bias towards the visual stimuli was determined by recording the N200 brain potential while participants emotionally reacted to the target (health-risk of smoking, nonhealth risk behaviour) and non-target (neutral) stimuli. N200 was extracted and analysed by using a mixed-design analysis of variance with target and non-target stimuli as within subject effects and types of moral identity as between subject effects. Attentional bias towards visual stimuli interacted significantly with the different levels of moral identity in the central part of the brain. High internalisation trait indicated shorter N200 latency when reacted to the health-risk of smoking stimuli than the non-health risk behaviour stimuli. An important insight regarding to moral psychology in relation to youth health risk behaviour was highlighted to focus for the development of the health promotion and education in future.
Effect of Regulated Type-2 Diabetes Mellitus on the Ocular Surface
Authors:   Yıldırım Beyazıt University Yenimahalle Education and Training Hospital Department of Ophthalmology, Ankara, 06900, Turkey
Published: March 2024

The aim of this study was to see whether well-regulated Type-2 diabetes mellitus (DM) under than 10 years impacted meibography and tear film break-up time. DM (n=45) and normal subjects (n=45) were recruited. Two years’ mean glycated hemoglobin data were calculated as the regulation indicator. Eye examination followed by noninvasive tear break‑up time (NTBUT) measurement and then meibography were conducted. Regression analyses corrected for age and gender were used for comparisons between groups. Pearson correlation analysis was used to examine the linear relationship between NTBUT and meibomian gland loss to mean glycated hemoglobin. A value of p<0.05 was considered statistically significant. The meiboscale comparisons within groups did not show any statistical difference. The mean meibomian gland loss comparisons between groups for the right lower eyelid (r=0.017, p=0.69), right upper eyelid (r=0.04 p=0.24), left lower eyelid (r=0.009, p=0.68) and left upper eyelid (r=0.027, p=0.13) were all similar. NTBUT for right and left eye were similar between groups (p=0.69 and p=0.36 respectively). Pearson’s correlation did not show any significant correlation between glycated hemoglobin, NTBUT and gland loss. In conclusion, it was found that patients with less than 10-year disease duration under DM regulation had similar ocular surfaces to normal subjects.
Mammary Angiosarcoma in an Adolescent : A Case Report
Authors:   Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia.
Published: March 2024

Mammary angiosarcoma is an extremely rare and highly aggressive malignant tumour of vascular origin. It can be divided into 2 types; primary angiosarcoma which develops de-novo and secondary angiosarcoma which occurs as a complication of post-radiotherapy or chronic lymphoedema. We present a case of a 19-year-old adolescent with a large right breast mass for the duration of 9 months. The core biopsy was reported as an angiosarcoma. She did not haveany previous breast pathology. She underwent a right mastectomy, followed by adjuvant radiotherapy. She developed scalp and skull metastases 5 months postsurgery and was currently undergoing palliative chemotherapy. There is a lack of international consensus on the management of mammary angiosarcoma due to its rarity. The main modality of management is surgery, preferably mastectomy. Radiotherapy and chemotherapy are sometimes given in an attempt to prevent or treat local recurrence and metastasis.
A Novel Approach in Elucidating the Interaction of Ecology, Biology and Social (Eco-bio-social) Factors with Serum Metabolites and Its Pathway among Polyps and Colorectal Cancer: A Study Protocol
Authors:   Department of Public Health Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia
Published: March 2024

The increasing number of colorectal cancer (CRC) incidences and mortality rates have caused an increasing burden on the healthcare system of the involved countries. This will impact the important economic components as a burden including direct medical care and non-medical costs and have caused productivity losses among patients and caregivers. Early diagnosis is important to help in reducing mortality rates of CRC and enhancing disease treatments. Besides genetic pathways, lifestyle imbalance and environmental factors also are reported as the main causes of CRC.However, most of the previous studies only focused on one factor at a time which limit the understanding of how these factors could be manipulated in the disease biomarkers finding. Hence, this study helps to build a novel protocol to provide a better insight into the effects of the ecology, biology, and social factors on the differential level of a polyp and CRC serum metabolites that could potentially be used to distinguish patients with polyp or CRC. The finding of the study could serve as a potential biomarker that could be used in the development of new screening tools to enhance early screening of polyps and CRC.
Legitimating Policy Branding: Constructing “Sellability” of Sweden’s Feminist Foreign Policy
Authors: Karlsson Isabelle
Published: March 2024

This article examines how foreign policy branding is legitimated as a response to human rights crises. Drawing on legitimation theory (van Leeuwen, 2007), this study takes a discourse perspective with a focus on the enactment of foreign policy in communication and argues that legitimacy is the foundation for constructing a convincing and credible image of a country and its foreign policy. Building on the example of Sweden’s feminist foreign policy and an analysis of relevant policy documents, three themes were formulated. These illustrate that Sweden’s feminist foreign policy branding was legitimated by framing the policy as a form of “good” activism, creating a knowledge brand of the policy, and aligning the policy branding with established discourses of solidarity. Thus, the study suggests that a branding logic imposed by the attention economy leads foreign policy communication to focus on constructing “sellability” of foreign policy, legitimating it in ways that make it relatable to wider publics. This article contributes to foreign policy communication research through the conceptual development of foreign policy branding.
Обзор II Научно-практической конференции в гибридном формате «Достижения, проблемы и перспективы в гематологии»
Authors: Шуваев В. А.
Published: March 2024

16–17 июня 2023 г. в Коломне состоялась II научно-практическая конференция «Достижения, проблемы и перспективы в гематологии», организованная Ассоциацией гематологов Московской области. В ходе конференции ведущими отечественными гематологами были представлены самые актуальные сведения о современных достижениях в области диагностики и терапии широкого спектра болезней и новообразований системы крови, а также о проведении научных исследований и правовых аспектах при лечении данных заболеваний. Особенностью докладов была их практическая направленность и обмен опытом с участниками конференции.
Keratoprosthetics as a visual rehabilitation method in patients with graft-versus-host disease
Authors: Belov Dmitrii F. , Nikolaenko Vadim P. , Petukhov Vladimir P.
Published: March 2024

The article is concerned with the treatment of a patient with allogeneic hematopoietic stem cell transplantation (HSCT) complicated by graft-versus-host disease with severe ocular manifestations. Hematopoietic stem cell transplantation is the standard therapy for a number of hemoblastoses and hereditary blood diseases, ensures the restoration of the immune system, however, in 40–60% of cases it is complicated by the development of graft-versus-host disease, with a five-year survival rate of no more than 40%. Patient S., 22 years old, was admitted to the ophthalmological center of Saint Petersburg Multifield Hospital No. 2 in 2019 with a diagnosis of “Acute keratitis, corneal ulcer of both eyes”. History of hematopoietic stem cell transplantation in 2018, complicated by graft-versus-host disease with multiorgan damage development was present. In total during the period 2019–2022, 7 tectonic keratoplasties were performed on both eyes, as well as penetrating keratoplasty on the left eye. After inflammation setback and left eye vascularized corneal leukoma formed, in December 2022, the first stage of keratoprosthetics (installation of the support element) was performed, and in May 2023, the second stage (implantation of the optical cylinder) took place. Visual acuity in one month after the implantation of the keratoprosthesis increased from light perception to 20/100, no correction possible. The use of “classical” methods of corneal ulcer perforation treatment in patients with graft-versus-host disease is ineffective due to the severe ocular surface xerosis, and keratoprosthetics seems to be the only effective method for restoring visual functions.
Possibilities of reparative therapy in the treatment of patients with xerotic changes in the cornea
Authors: Brzheskiy Vladimir V. , Bobryshev Vsevolod A.
Published: March 2024

In recent years, in the treatment of patients with dry eye syndrome, drugs that, along with moisturizing, also have specific metabolic properties, due to the additional medicinal ingredients contained in them, deserve more and more attention. The article presents comparative data on the preparations of “artificial tears” and so-called keratoprotectors registered in Russia. In addition, a number of experimental and clinical studies by domestic authors evaluating the pharmacological and clinical effect of the new keratoprotector SPHERO®oko were reviewed. Much attention is also paid to the consideration of the original direction of SPHERO®oko application — its introduction into the corneal stroma (together with a dye) for cosmetic and functional keratopigmentation in the presence of extensive iris defects. The authors of the literature review, taking into account the results of numerous experimental studies and some clinical observations, believe that the use of SPHERO®oko has quite great opportunities in the complex treatment of xerotic changes of the cornea and conjunctiva. At the same time, it is of interest to continue the research on the possibilities of intrastromal administration of colored SPHERO®oko for keratopigmentation in the presence of extensive iris defects.
Weighted Compressive Sensing Applied to Seismic Interferometry: Wavefield Reconstruction Using Prior Information
Authors: Saengduean Patipan , Snieder Roel , Wakin Michael B.
Published: March 2024

Seismic interferometry is widely used for passive subsurface investigation using seismic noise. The technique requires much storage for long noise records to suppress interferometric noise, which consists of spurious arrivals that do not correspond to the inter-receiver surface waves. Such long recordings may not be available in practice. Compressive sensing (CS), which is a wavefield reconstruction technique operating on incomplete data, may increase the availability, and reduce storage limitations of long noise time series. Using a numerical example of a linear array surrounded by sources and the Fourier basis for a sparse transform, we show that inter-receiver wavefields can be recovered at the locations where seismometers are unavailable, reducing the storage required for interferometry. We propose and develop a weighted CS algorithm that helps suppress the spurious arrivals by incorporating a priori information about the arrivals of surface waves that can be expected.
Çocuğu Okul Öncesi Eğitime Devam Eden Annelerin Çocuğa Yönelik Şiddete Karşı Duyarlıklarının İncelenmesi
Authors: TEMİZ Gülay , GÜLDAĞ Öznur
Published: March 2024

Bu çalışmada, okul öncesi dönemde çocuğu olan annelerin çocuğa yönelik şiddete duyarlıklarının bazı değişkenler açısından incelenmesi amaçlanmıştır. İlişkisel tarama modeline uygun olarak tasarlanan bu araştırmada, basit seçkisiz yöntemle belirlenen, çocuğu okul öncesi eğitime devam eden, yaşları 30 ile 41 yaş ve üstü olan 560 anne çalışma grubunu oluşturmuştur. Çalışma grubundaki annelerin kişisel özellikleri Kişisel Bilgi Formu ile belirlenmiş ve annelerin çocuğa yönelik duyarlıklarını belirlemek amacıyla da Özyürek (2017) tarafından geliştirilen Çocuğa Yönelik Şiddete Duyarlık Ölçeği kullanılmıştır. Elde edilen bulgulara göre; okul öncesi dönemde çocuğu olan annelerin çocuğa yönelik şiddete duyarlık düzeylerinin yüksek olduğu, çocuğa yönelik şiddete duyarlık puanını etkileyen en önemli faktörün aile yapısı olduğu, annelerin çocuğa yönelik şiddete duyarlıklarının çalışma durumlarına ve çocuk sayılarına göre farklılık gösterdiği ancak ele alınan diğer değişkenler açısından herhangi bir farklılığın görülmediği ortaya konmuştur.
Preparation and Evaluation of Mouth Dissolving Tablet of Albendazole Using Different Concentrations of Super-Disintegrant
Authors: Bavaskar Kedar Rupa , Pote Supriya , Vidhate Prasad , Patil Vinit , Jain Ashish
Published: March 2024

Anthelmintic medications are anticipated to act more quickly and have greater absorption. Mouth-dissolving albendazole tablets were created using a direct compression approach and a mixture of super disintegrants to accomplish rapid disintegration of the tablets in the oral cavity. The preparation of ten batches of mouth-dissolving tablets using different grades of Kollidon, crospovidone, sodium starch glycolate, and croscarmellose sodium as super disintegrants produced the greatest results. For a compatibility investigation, FTIR was used to characterize the drug and physical mixture. An optimization technique was used to forecast the most effective formulation out of all the prepared combinations. All the physical characteristics of the tablet are within the limit. All preformulation results indicated good flow properties. Disintegration time and drug content of the F4 batch were found to be 28 seconds and 95.69%, respectively. In vitro release of the drug was performed in a phosphorus buffer pH 6.8 for 40 min, in which F4 shows maximum drug release. Based on the stability studies, it was confirmed that the optimized formulation remained at accelerated stability conditions. It was discovered that the mouth-dissolving tablet exhibits effective drug release.
“Parkinson is a disease for lorens”. On Richard Wagner’s autopathography
Authors: OKUPNIK MAŁGORZATA
Published: March 2024

Celem szkicu jest próba „podejścia metafizycznego” (postulowanego przez Olivera Sacksa) i empatycznej
lektury opowieści pacjentów zmagających się z chorobą Parkinsona. Choroba ta jest
przewlekła i nieuleczalna, skutkuje brakiem kontroli nad ciałem i fizycznością. Jest widoczna
dla otoczenia, dlatego jest chorobą stygmatyzującą i trudną do zaakceptowania czy oswojenia.
Analizie poddana została autopatografia rumuńsko-niemieckiego pisarza Richarda Wagnera.
Autor próbuje przebić się przez mur niezrozumienia i z własnej perspektywy opowiedzieć o tym,
przez co przechodzi.
I want to break free: Successor Emancipation in Family Business
Authors: RADU-LEFEBVRE Miruna , Lefebvre Vincent
Published: March 2024

Family business successors live at the nexus of past, present and future, nourished and inspired by past legacies while also craving to build a brand-new future. The senior generation is generally the guardian of firm continuity in charge of preserving past achievements, whereas the next generation might dream about introducing change and innovation within the current landscape of the family firm. Yet these attempts too often trigger resistance and anxiety in the senior generation, who might respond with increasing control and suspicion to any tentative of challenging the status quo such as transforming current products, services, business models, or organizational structures. Successors operate at the intersection of these opposite forces of conservatism and reform, and one of their major issues is that they need to handle them effectively, that is without jeopardizing family relations and harmony nor losing themselves into the process. Unless they succeed in doing so, succession failure might follow. By combining two different streams of literature grounded in distinct disciplines, namely succession literature in family business and emancipation literature in entrepreneurship, we reveal successor emancipation as a novel explanation of why successions fail and offer some practical advice on how to handle these tensions in intra-family succession.

Received: 10 May 2023 Accepted: 28 Jun 2023
Oskrbovalne verige znanja: Smernice za zeleni in digitalni prehod
Authors: Obrecht Matevž , Cvahte Ojsteršek Tina , Čuček Mateja , Fale Martin , Kajba Milena , Vičič Polona , Slomšek Šlamberger Bojana , Pavić Lazar
Published: March 2024

Znanstvena monografija zajema najsodobnejše ugotovitve s področja trajnostnega razvoja in digitalizacije in njihovo aplikacijo na področje managementa v logistiki in oskrbovalnih verigah. Teoretični del monografije odpirajo poglavja, ki se nanašajo na pojasnitev osnovnih pojmov s področja trajnostnega razvoja, kot so cilji trajnostnega razvoja, okoljska politika, trajnostna proizvodnja in potrošnja, delitvena ekonomija, koncept odrasti in ekonomija blaginje. V nadaljevanju so predstavljeni najsodobnejši trendi s področja trajnosti in povezovanja področij digitalizacije s poudarkom na tem, kaj je aktualno in kaj mlajše generacije vidijo kot priložnosti za prioritetni razvoj. Teoretični del se zaključi s predstavitvijo kompetenčnih modelov s področja trajnosti in digitalizacije ter s predstavitvijo vseživljenjskega učenja kot rešitve za hitrejše pridobivanje znanj s področja trajnostnega razvoja in digitalizacije, saj je zaznano pomanjkanje teh znanj pri posameznikih, ki so končali formalno izobrazbo v času, ko sta trajnost in digitalizacija predstavljali obrobni tematiki in še nista bili tako vpeti v izobraževanje in prioritete logistike in oskrbovalnih verig. Raziskovalni del monografije se začne s predstavitvijo vključenosti trajnostnega razvija v obstoječi zakonodajni okvir. V nadaljevanju so predstavljeni rezultati vključenosti trajnostnih in digitalnih kompetenc v slovenske visokošolske programe in analiza prekrivanja le teh. Ključni raziskovalni del pa predstavljajo rezultati kvantitativne raziskave, ki se nanašajo na identifikacijo nujno potrebnih znanj, spretnosti in veščin s področja trajnostnega razvoja in digitalizacije v logistiki in oskrbovalnih verig, za nemoten hkratni zeleni in digitalni prehod v družbo 5.0. ter razlike v ključnih prioritetnih področjih, ki jih zaznavamo med gospodarstvom, mladimi in akademiki.
Gender Difference in Nutritional Knowledge, Dietary Pattern and Nutritional Status of Undergraduates in Tartous University, Syria
Authors: Younes Samer
Published: March 2024

Introduction: Poor nutritional knowledge at early stage of life suggests developing poor dietary habits that later leads to obesity and attendant complications of non-communicable diseases. This study examined gender differences in nutritional knowledge, dietary pattern and the prevalence of overweight/obesity among students of a private tertiary institution in Tartous University, Syria.
Ceviz (Juglans regia L.) Fidanı Üretiminde Modern Yaklaşım: Doku Kültüründe Yüzey Sterilizasyonunun ve Kültür Başlatmanın Detaylı Çözümlemesi
Authors: Özelçi Duygu
Published: March 2024

Bu çalışmada; Kozdere, Zengibar ve Chandler ceviz çeşitleri için etkili bir yüzey sterilizasyonunun geliştirilmesi, kültür başlatmada farklı besi ortamları ve 6-benzilaminopürin (BAP) konsantrasyonlarının etkileşimi araştırılmıştır. Eksplant olarak ceviz çeşitlerinin aksiller tomurcukları kullanılmıştır. Doku kültürü çalışmalarının ilk aşaması yüzey sterilizasyonudur. Yüzey sterilizasyonu başarılı olan bitkilerin mikroçoğaltımı yapılabilmektedir. Araştırmada, ceviz materyallerine % 20, 30 ve 40 dozlarında sodyum hipoklorit ile sodyum hipokloritin yanı sıra bakır sülfat kullanılarak yüzey sterilizasyonu yapılmıştır. Yüzey sterilizasyonunda en az kontaminasyon (% 8.16) ve kararma (% 22.45) ile en fazla tomurcuk sürmesi (% 69.39) % 30 sodyum hipoklorit ve bakır sülfat uygulamasında Kozdere çeşidinde görülmüştür. Kültür başlatma ortamı olarak Murashige ve Skoog (MS) ile Driver ve Kuniyuki Walnut (DKW) besi ortamları kullanılmıştır. Besi ortamlarına 0.5, 1 ve 2 mg L-1 BAP eklenmiştir. Ceviz çeşitlerinin çoğaltılmasında DKW ortamı MS ortamına göre daha başarılı bulunmuştur. DKW ortamına 2 mg L-1 BAP ilavesi tüm çeşitler için sürgün uzaması, eksplant başı sürgün sayısı ve yaprak sayısı için en iyi sonuçları vermiştir. Ceviz çeşitleri arasında sürgün uzaması ölçümlerinde Kozdere çeşidinde, Zengibar ve Chandler çeşitlerine göre istatistiksel olarak anlamlı farklılık bulunmuştur. Sonuç olarak, ceviz çeşitlerinin in vitro çoğaltımında Kozdere çeşidinin kullanılabileceği ortaya konulmuştur. Zengibar ve Chandler çeşitlerinin doku kültüründe çoğaltımında yöntem belirlemek için daha kapsamlı çalışmalara ihtiyaç olduğu görülmektedir.
Médicos de Família e Nutricionistas nos Centros de Saúde, Comentário a “Hábitos Alimentares das Pessoas com Diabetes Mellitus Tipo 2 em Portugal: Um Estudo Transversal”
Authors: Prazeres Filipe
Published: March 2024

N/a.
Relationship Disease Management and Parenting Stress on Families Ability to Care For Schizophrenia
Authors: Iswanti Dwi Indah , Motuho Mendrofa Fery Agusman , Nursalam Nursalam , Rizki Fitryasari  , Kandar Kandar
Published: March 2024

Introduction: The inability of families to care for schizophrenia is caused by minimal knowledge and not having sufficient training or formal support. Families are frustrated and make it a burden to care for schizophrenia. The research aimed to determine the relationship between disease management and Parenting stress on the family's ability to care for schizophrenia.
Method: Quantitative design with a cross-sectional approach was used. The sample size was 135 families caring for schizophrenia using a purposive sampling technique. The independent variable was disease management and parenting stress, and the dependent variable was the family's ability to care for schizophrenia. The disease management questionnaire was based on the concept of family empowerment by Zhou and Budi Anna Keliat. The parenting stress management questionnaire was developed from the neurobiology of stress concept from Murison, and the family ability questionnaire to care for schizophrenia uses the parenting Tasks in Caring for an Adult with Mental Illness Scale (CTiCAMIS). Data analysis used the Chi-square test with a level of 95%.
Results: There was a relationship between disease management (p-value = 0.002 (<0.05)) and parenting stress (p-value = 0.000 (<0.05)) with the family's ability to care for schizophrenia patients.
Conclusions: Disease management ability and parenting stress are closely related to the family's ability to care for schizophrenia. Efforts from mental health workers to provide education, training, and assistance are needed through family empowerment programs development to increase the family ability.
EMPOWERING RESILIENCE USING BEHAVIORAL ACTIVATION TECHNIQUES
Authors: Kushartati Sri , Sholichah Mutingatu , Anam Choirul
Published: March 2024

The recurrent landslides in the Banjarnegara region has far-reaching consequences, leading to widespread unemployment as agricultural lands become unusable. To enhance the resilience of survivors, an intervention in the psychosocial context was employed, utilizing the behavioral activation technique. Fourteen women, representing family units, spanning ages from 20 to 65, participated in the program. These individuals bore the dual burden of losing their homes and enduring trauma. Analysis of resilience scale data was conducted using the Wilcoxon-signed rank test technique, revealing compelling results with Z=-2.805 and p=0.005 (p<0.01), show a significant increase in the resilience of landslide survivors through the behavioral activation technique. Recommendations for subsequent cycles include: (1) widespread application of the behavioral activation technique to empower other disaster survivors, (2) the implementation of collaborative interventions to address geographic vulnerabilities, and (3) the development of targeted interventions for male survivors to facilitate their return to work in their respective villages.
Clinical, Laboratory, Imaging and Electrocardiographic Differences between Patients with Lyme Disease and Patients with Lyme Disease and B. divergens Antibodies
Authors: Folgueras María , Gonzalez Luis Miguel , Collazos Julio , Rodríguez-Pérez Mercedes , Pérez-ls Laura , Diaz-Arias Javier , Meana María , Revuelta Belen , Montero Estrella , Asensi Víctor
Published: March 2024

Clinical and analytical differences between adult patients monoinfected with Borrelia burgdorferi sensu lato (s.l.) and patients infected with B. burgdorferi s.l. who also had IgG antibodies against Babesia divergens have not been reported so far. Both Lyme disease caused by B. burgdorferi and babesiosis caused by B. divergens, endemic in Asturias, Northwestern Spain, are transmitted by Ixodes tick bites. Clinical, laboratory and other diagnostic tests characteristics (imaging, electro-cardiographic-ECG) of 120 residents of Asturias with confirmed B. burgdorferi s.l. infection, di-agnosed during 2015-2017, of whom 47 (39.2%) had B. divergens IgG antibodies, were retrospec-tively compared. Cardiorespiratory symptoms were reported in 9/47 (19.2%) patients with Lyme disease and B. divergens IgG antibodies compared to 4/73 (5.5%) patients with B. burgdorferi s.l. monoinfection (P=0.02). Dyspnea was recorded in 4/47 (8.5%) patients with Lyme disease and B. divergens IgG antibodies compared to 1/73 (1.4%) monoinfected (P=0.07). In addition ECG atri-oventricular (AV) block, mostly 1st degree, was detected in 5/47 (15.6%) patients with Lyme dis-ease and B. divergens IgG antibodies compared to 1/73 (2.6%) B. burgdorferi s.l. monoinfected (P=0.09). No other clinical, laboratory or other tests differences were observed between B. burgdorferi and B. divergens IgG antibodies carriers and B. burgdorferi monoinfected. We con-cluded that patients with Lyme disease and B. divergens IgG antibodies had more frequent car-diorespiratory symptoms, mainly dyspnea, compared to B. burgdorferi monoinfected patients. These symptoms were unrelated to anemia. ECG AV block, perhaps induced by summative myo-cardial damage due to either infections or B. divergens induced lung microcirculation slow-ing-down, might play a role in the cardiorespiratory dysfunction.
Field Report of the 2024 Noto Peninsula Earthquake—Current Status and Challenges of Evacuation Centers in Wajima City
Authors: Itatani Tomoya , Kojima Michio , Tanaka Junichi , Horike Ryo
Published: March 2024

On January 1, 2024, a large earthquake occurred in Japan’s Noto region. Many buildings collapsed as a result of violent shaking. Electricity and water supplies were cut off and communications were disrupted. Immediately after the earthquake, we visited Noto and conducted disaster-relief activities. This report integrates and discusses the results of the site visits, information broadcasts by public institutions, and previous research. Evacuation centers lacked water and proper sanitation, leading to health issues, including infectious diseases. Disaster Medical Assistance Teams (DMAT) were delayed in implementing infection control measures. Isolated evacuation centers faced communication and supply challenges. Infrastructure restoration, power supply, and toilet facilities at evacuation centers were delayed because of geographical challenges. There was a lack of intervention by medical professionals in evacuation centers because the DMATs were forced to invest manpower in rescue operations. It is important to have a team that can determine and carry out the necessary activities on site, even without instructions from the DMAT. It is believed to be effective to decide in advance how volunteer teams and the private sector will conduct their activities, assuming that they will be unable to contact public institutions during a disaster. In large-scale disasters, evacuees must operate evacuation centers autonomously. To achieve this, it is necessary for residents to form healthy communities regularly. A serious disaster is expected to soon occur in Japan. We hope that the experience of this disaster will be useful for preparing for future disasters.
Effects of low and high maternal protein intake on fetal skeletal muscle miRNAome in sheep
Authors: Akyüz Bilal , Sohel Md Mahmodul Hasan , Konca Yusuf , Arslan Korhan , Gürbulak Kutlay , Abay Murat , Kaliber Mahmut , White Stephen N. , Cinar Mehmet Ulas
Published: March 2024

Prenatal maternal feeding plays an important role in fetal development and has potential to cause long-lasting epigenetic modifications. MicroRNAs (miRNAs) are non-coding, single-stranded RNAs that serve as one epigenetic mechanism. Though miRNAs have crucial roles in fetal programming, growth, and development, there are limited data regarding maternal diet and sheep miRNA expression. Therefore, weanalyzed high and low maternal dietary protein for miRNA expression in sheep fetal longissimus dorsi. Pregnant ewes were fed an isoenergetic high-protein (HP, 160–270 g/day), low-protein (LP, 73–112 g/day), or standard protein diet (SP, 119–198 g/day) during pregnancy. miRNA expression profiles were evaluated using the Affymetrix GeneChip miRNA 4.0 Array. Twelve up-regulated, differentially expressed miRNAs (DE miRNAs) were identified targeting 65 genes. The oar-3957-5p miRNA was highly up-regulated in LP and SP compared to HP. Previous transcriptome analysis identified integrin and non-receptor protein tyrosine phosphatase genes targeted by miRNAs detected in the current experiment. A total of 28 GO terms and 10 pathway-based gene sets were significantly (padj < 0.05) enriched in target genes. Most genes targeted by identified miRNAs are involved in immune and muscle disease pathways. Our study shows dietary protein intake during pregnancy affects fetal skeletal muscle epigenetics via miRNA expression.
Negotiation of Calcified Canals
Authors: Chaniotis Antonis , Sousa Dias Hugo , Chanioti Anastasia
Published: March 2024

Hard tissue apposition along the root canal walls is a slow, normally occurring physiological aging process. In response to tooth wear, local deposition of hard tissue may also occur in the pulp at a slow pace. Sometimes, the rate of hard tissue deposition acceleration may seem to be uncontrolled after dental trauma, autotransplantation, and orthodontic therapy, leading to rapid partial or total obliteration of the root canal space. This situation is called calcific metamorphosis (CM) or pulp canal obliteration (PCO). Although the incidence of pulpal necrosis in these teeth is believed to be infrequent, conventional endodontic therapy in severely calcified canals poses extreme difficulties and a higher risk for procedural accidents. This article aims to review the available approaches for the predictable negotiation of calcified canals and to introduce the buckling resistance activation test (BRAT) technique.
Role of Protein Tyrosine Phosphatase Receptor Type E (PTPRE) in Chemoresistant Retinoblastoma
Authors: Mohren Lars , Doege Annika , Miroschnikov Natalia , Dräger Oliver , Busch Maike Anna , Dünker Nicole
Published: March 2024

Protein tyrosine phosphatase receptor type E (PTPRE) is a member of the “classical” protein tyrosine phosphatase subfamily and regulates a variety of cellular processes in a tissue-specific manner by antagonizing the function of protein tyrosine kinases. PTPRE plays a tumorigenic role in different human cancer cells, but its role in retinoblastoma (RB), the most common malignant eye cancer in children, remains to be elucidated. Etoposide resistant RB cell lines and RB patients display significant higher PTPRE expression levels compared to chemosensitive counterparts and the healthy human retina, respectively. PTPRE promotor methylation analyses revealed that PTPRE expression in RB is not regulated via this mechanism. Lentiviral PTPRE knockdown (KD) induced a significant decrease in growth kinetics, cell viability, and anchorage independent growth of etoposide resistant Y79 and WERI RB cells. Caspase-dependent apoptosis rates were significantly increased and a re-sensitization for etoposide could be observed after PTPRE depletion. In vivo chicken chorioallantoic membrane (CAM) assays revealed decreased tumor formation capacity as well as reduced tumor size and weight following PTPRE KD. Expression levels of miR631 were significantly downregulated in etoposide resistant RB cells and patients. Transient miR631 overexpression resulted in significantly decreased PTPRE levels and concomitantly decreased proliferation and increased apoptosis levels in etoposide resistant RB cells, impacts mirroring PTPRE KD effects and indicating PTPRE regulation via this miR. Additionally, PTPRE KD led to altered phosphorylation of protein kinase SGK3 and - dependent on the cell line - also AKT and ERK1/2, suggesting potential PTPRE downstream signaling pathways. In summary, these results indicate an oncogenic role of PTPRE in chemoresistant retinoblastoma.
Evolution of Complexity of Palliative Care Needs and Patient Profiles according to the PALCOM Scale: Pooled Analysis of the Cohorts for the Development and Validation of the PALCOM Scale in Advanced Cancer Patients
Authors: Tuca Albert , Viladot Margarita , Carrera Gemma , Llavata Lucia , Barrera Carmen , Chicote Manoli , Marco-Hernández Javier , Padrosa Joan , Zamora-Martinez Carles , Grafia Ignacio , Pascual Anais , Font Elena , Font Carme
Published: March 2024

Introduction: Identifying the complexity of palliative care needs is a key aspect of referral to specialised multidisciplinary early palliative care (EPC) teams. The PALCOM scale is an instrument consisting of five multidimensional assessment domains, developed in 2018 and validated in 2023, to identify the level of complexity in patients with advanced cancer.
Objectives: The main objective of this study was to determine the degree of instability (likelihood of level change or death), health resource consumption and survival of patients according to the level of palliative complexity assigned at the baseline visit during a 6-month follow-up.
Method: An observational, prospective, multicentre study was conducted using pooled data from the development and validation cohort of the PALCOM scale. The main outcome variables were: a) instability ratio (IR), defined as the probability of level change or death; b) emergency department visits; c) days of hospitalisation; d) hospital death; e) survival. All variables were analysed monthly according to the level of complexity assigned at the baseline visit.
Results: A total of 607 patients with advanced cancer were enrolled. According to the PALCOM scale, 20% of patients were classified as low complexity, 50% as medium and 30% as high complexity. The overall IR was 45% in the low complexity group, 68% in the medium complexity group and 78% in the high complexity group (p
Improving Accessibility to Patients with z0 Interstitial Lung Disease (ILD): Barriers to Early Diagnosis and Timely Treatment in Latin America.
Authors: Figueiredo Ricardo G. , Duarte Nathalia Filgueiras Vilaça , Campos Daniela Carla Barbosa , Verduzco Manuel de Jesus Diaz , Márquez Ángel Alemán , De Araujo Gabriela Tannus Branco , Rubin Adalberto Sperb
Published: March 2024

Abstract: Delayed initiation of effective antifibrotic therapy in patients with interstitial lung diseases (ILD) may influence the progression and outcome of the disease. This study analyzes the differences in the journey of patients with ILD in the Brazilian and Mexican health systems. An evaluative study was conducted in reference centers for interstitial lung diseases in Brazil and Mexico with a panel of four specialists. The patient's journey in both countries begins when the patient seeks medical care after observing a chronic respiratory symptom. In both countries, due to diagnostic complexity, these patients arrive at ILD referral centers at an advanced stage of the disease. Once diagnosis is established, the treatment onset differs between Mexico and Brazil. Antifibrotic drugs are not yet available by SUS in Brazil, and the purchase is unfeasible for most of the population, which forces specialists to only offer support to patients until the treatment can get the drug. In Mexico, antifibrotics have been available in health sectors since 2018. Brazil and Mexico have several similarities regarding the initial journey of the patient due to diagnosis difficulties, but the outcome tends to be different due to a difference in access to treatment with antifibrotics. For this reason, advancing health policies that ensure proper treatment for patients with ILD is crucial for the sustainability and reliability of the health system.
Improving Accessibility to Patients with Interstitial Lung Disease (ILD): Barriers to Early Diagnosis and Timely Treatment in Latin America.
Authors: Figueiredo Ricardo G. , Duarte Nathalia Filgueiras Vilaça , Campos Daniela Carla Barbosa , Verduzco Manuel de Jesus Diaz , Márquez Ángel Alemán , De Araujo Gabriela Tannus Branco , Rubin Adalberto Sperb
Published: March 2024

Abstract: Delayed initiation of effective antifibrotic therapy in patients with interstitial lung diseases (ILD) may influence the progression and outcome of the disease. This study analyzes the differences in the journey of patients with ILD in the Brazilian and Mexican health systems. An evaluative study was conducted in reference centers for interstitial lung diseases in Brazil and Mexico with a panel of four specialists. The patient's journey in both countries begins when the patient seeks medical care after observing a chronic respiratory symptom. In both countries, due to diagnostic complexity, these patients arrive at ILD referral centers at an advanced stage of the disease. Once diagnosis is established, the treatment onset differs between Mexico and Brazil. Antifibrotic drugs are not yet available by SUS in Brazil, and the purchase is unfeasible for most of the population, which forces specialists to only offer support to patients until the treatment can get the drug. In Mexico, antifibrotics have been available in health sectors since 2018. Brazil and Mexico have several similarities regarding the initial journey of the patient due to diagnosis difficulties, but the outcome tends to be different due to a difference in access to treatment with antifibrotics. For this reason, advancing health policies that ensure proper treatment for patients with ILD is crucial for the sustainability and reliability of the health system.