bluuebunny/crossref_metadata_2025 huggingface dataset:
Truck Driving Assessment for Chinese Logistics and Transportation Companies Based on a Safety Climate Test System
Authors: Xiong Jian , Chen Zhenhan
Published: May 2024

By applying the “safety atmosphere” measurement theory to Chinese management companies engaged in road transportation, a corporate and individual safety risk assessment system was established that is consistent with the management and cultural climate in China, thereby reducing the driving safety risk of truck drivers. The system realizes the safety risk assessment of enterprises, fleets and individuals in the form of test scales by constructing a structural model of the enterprise safety atmosphere, including the management, communication, and supervision of enterprises, fleets, and individuals. The safety climate was modeled using a two-level framework, at the organizational level and fleet level, and three dimensions of test items for each level were obtained by exploratory factor analysis. The three dimensions of safety management, safety supervision, and safety priority at the organizational level, and the three dimensions of positive communication, safety awareness, and self-discipline at the fleet level, respectively, passed a valid factorial test (p < 0.01). Finally, the validity of the system evaluation results was verified by relying on the actual in-vehicle monitoring data and accident records of the corporate transportation fleet. The results show that the total test scores at the organizational level and the fleet level are significantly correlated with their driving risk behaviors, and both are linearly and negatively correlated with the number of accidents per thousand kilometers. This indicates a high degree of consistency between the system’s test results and actual risky accidents.
Characterization of Japanese Encephalitis Virus Isolated from Persistently Infected Mouse Embryo Cells
Authors: Kondo Yume , Komiya Tomoyoshi
Published: May 2024

Japanese encephalitis virus (JEV) has a positive-sense single-stranded RNA genome and belongs to the genus Flavivirus of the family Flaviviridae. Persistent JEV infection was previously shown in pig blood cells, which act as a natural reservoir of this virus. We aimed to determine the pathogenicity factors involved in persistent JEV infection by analyzing the pathogenicity and genome sequences of a virus isolated from a persistent infection model. We established persistent JEV infections in cells by inoculating mouse fetus primary cell cultures with the Beijing-1 strain of JEV and then performing repeated infected cell passages, harvesting viruses after each passage while monitoring the plaque size over 100 generations. The virus growth rate was compared among Vero, C6/36, and Neuro-2a cells. The pathogenicity was examined in female ICR mice at several ages. Additionally, we determined the whole-genome sequences. The 134th Beijing-1-derived persistent virus (ME134) grew in Vero cells at a similar rate to the parent strain but did not grow well in C6/36 or Neuro-2a cells. No differences were observed in pathogenicity after intracerebral inoculation in mice of different ages, but the survival time was extended in older mice. Mutations in the persistent virus genomes were found across all regions but were mainly focused in the NS3, NS4b, and 3′NCR regions, with a 34-base-pair deletion found in the variable region. The short deletion in the 3′NCR region appeared to be responsible for the reduced pathogenicity and growth efficiency.
Future Long-Baseline Neutrino Experiments
Authors: Terranova Francesco
Published: May 2024

Long-baseline neutrino experiments represent the optimal platforms for probing the lepton Yukawa sector of the Standard Model, and significant experiments are either under construction or in the planning stages. This review delves into the scientific motivations behind these facilities, which stem from the pivotal 2012 discovery of the θ13 mixing angle. We provide an overview of the two ongoing projects, DUNE and HyperKamiokande, detailing their physics potential and the technical hurdles they face. Furthermore, we briefly examine proposals for forthcoming endeavors and innovative concepts that could push beyond conventional Superbeam technology.
Gloss to a judgement of CJEU of 30th or March 2023, C-618/21 AR and others versus PK S.A. and others
Authors: Kucharski Bartosz
Published: May 2024

Judgement of CJEU of 30th of March 2023, C-618/21 AR and others versus PK S.A. and others address the question referring to the possibility of estimation of insurance compensation for the damaged car due to the injured from insurance against civil liability in respect of the use of motor vehicle as hypothetical costs of repair. The author approves the judgement of CJEU which says that national law may limit the redress accessible to the injured party from the insurer to the monetary compensation, and that such compensation may not be lower than compensation accessible according to a national law on general basis. As far as admissibility of estimation of the insurance compensation as the hypothetical costs of repair in the Polish law the author adopts the compromise view pointing that it depends on the circumstances of the case. As a rule the insured party has the right to such compensation without the need of proving how much he has spent for the repair, but the injured does not have such right if the car was sold without repair
Analisis dan Evaluasi Pengujian pada Penerapan Metode Prototype dalam Software Engineering
Authors: Aldy Nifratama  , Tri Suratno  , Daniel Arsa
Published: May 2024

Masih banyak sekali badan usaha Kesehatan yang belum memanfaatkan teknologi dengan maksimal. Klinik pratama merupakan fasilitas pelayanan kesehatan yang menyelenggarakan pelayanan kesehatan perorangan yang menyediakan medis dasar atau spesialistik kepada pasien. Namun pada pelayanannya klinik tersebut masih menerapkan cara manual sehingga menyebabkan berbagai permasalahan seperti hilangnya data, tempat penyimpanan data yang terbatas, serta memerlukan pemeliharaan yang extra terhadap data yang ada. Oleh karena itu diperlukan sebuah sistem informasi yang dapat mengatasi permasalahan tersebut yaitu sistem informasi klinik pratama dokter yanti. tujuan penelitian ini yaitu untuk membuat sistem informasi klinik pratama dokter yanti dari rancangan yang telah ada agar dapat memudahkan para tenaga medis dalam memberikan pelayannya kepada masyarakat dengan menggunakan metode prototype. Setelah sistem dibuat menggunakan model prototype, selanjutnya dilakukan pengujian manual dengan menggunakan model black box testing dengan 33 fungsi uji dan 6 tester dan mendapatkan hasil 100% fungsi berjalan dengan baik. Kemudian dilanjutkan dengan melakukan pengujian menggunakan metode user acceptance testing  yang memberikan 10 pertanyaan kepada 10 responden dan hasilnya rata-rata responden setuju dengan sistem yang dibuat. Dan pengujian terakhir yang dilakukan setelah sistem di deploy ke server yaitu pengujian melalui  software dengan hasil yaitu pada aspek performance 100, accessibility 80, best practices 92, seo 91.
Optimasi Sistem Informasi Konsultasi Hukum melalui Pendekatan Pengujian Kombinasi White-box dan Black-box
Authors: Nurwicaksono Muhammad Agy , Lisa Irma Noor , Tiara Astia Rahma , Sidik Rangga
Published: May 2024

This study aims to test the legal consulting information system "Advogo" in the hope of finding deficiencies in the system that has been built, and opening up opportunities for improvement and further development of the system. Testing is done by 2 methods, white-box, and black-box testing. The white-box method used in this study is branch and basis path testing, while the black-box method used is the cause-effect graph. The limitation of white-box testing in this study is the SessionController.php file with Index, Create, Store, Show, and Update functions. While the limitations of the black-box are the creation of consultation sessions, authentication, and session bookings. The results of this study are the formation of 10 test cases for white-box testing with 100% valid results, and 14 test cases for black-box testing with 92% valid results, where there is 1 invalid test case so it is necessary to make improvements so that the system can function according to which are expected.
Prediksi Kelulusan Tepat Waktu Siswa SMK Teknik Komputer Menggunakan Algoritma Random Forest
Authors: Fatunnisa Arina , Marcos Hendra
Published: May 2024

School performance can be measured through student completion rates, which is a key indicator. Low graduation rates indicate problems in the education and learning system, which require timely intervention to prevent students from not completing their education. Therefore, predicting graduation rates is crucial for schools in order to determine students who are likely to not complete their education, so as to provide early assistance to improve their academic performance. This research is urgent because by understanding and predicting student completion, schools can allocate resources more effectively to support at-risk students, with the ultimate goal of improving graduation rates and overall school performance. This research uses random forest algorithm with graduation dataset. The distribution of training and test data selection uses stratified random sampling method to ensure a balanced representation of each class generated. The Random Forest model was successfully obtained through training and model evaluation using test data, showing an accuracy of 1.0 or equivalent to 100%. The use of the random forest algorithm on student graduation datasets can be an effective approach in supporting timely graduation prediction due to its high accuracy and the model's ability to recognize both graduating and non-passing students.
Sistem Informasi Manajemen Transaksi Layanan Fotografi di Qlise Photography
Authors: Al Faruqi Muhammad Haidar , Sudarmilah Endah
Published: May 2024

The rapid digital development has driven Qlise Photography, a provider of photography services including wedding, prewedding, and studio photography, to address the complexity in managing its services. The aim of this research is to enhance the efficiency in managing and booking photography services provided by Qlise Photography through the development of a Website-Based Information System. To tackle the challenges in managing services like wedding, prewedding, and studio photography, the primary approach adopted in this research is the waterfall method, utilizing PHP programming language and leveraging CodeIgniter Framework as the development tool. The findings of this research have positively impacted Qlise Photography, with the implementation of an optimal system. Previously manual, the process of booking photography services can now be accessed and managed efficiently through the online platform. System testing using the Black Box method and the application of the System Usability Scale (SUS) yielded a score of 77, categorizing it as GOOD, indicating a positive acceptance rate from users. This marks a significant step in improving customer experience and operational efficiency in addressing the challenges of photography services in the digital era.
Self Control and Organizational Commitment Views of Cyberloafing Behavior
Authors: Masruroh* Rina , Budiman Aris , Dodi Dodi , Komarudin Munir Nur , Irawan Nico
Published: May 2024

Internet facilities in the workplace are often misused for personal purposes, known as cyberloafing behavior. This study utilizes multiple linear regression analysis to understand the influence of self-control and organizational commitment on employees' cyberloafing behavior in private companies in Kuningan Regency, both partially and simultaneously, through the distribution of questionnaires as a data collection technique on 100 sampled employees. The results show that organizational commitment does not have a significant impact, while self-control can reduce cyberloafing behavior. These research findings can serve as recommendations for local private business owners to improve their employees' performance by enhancing control over cyberloafing behavior, focusing on self-control aspects, and also increasing employee work commitment.
Keywords: Cyberloafing; Self Control; Organizational Commitment; Employee Performace; Privat Employees
Determinants of Interest Purchasing Shallot Seeds of Varieties Thai Nganjuk (Tajuk)
Authors: Yuliansyah Dandy , Prasaja* Mukti , Junaedi Imam , Pratiwi Nuris
Published: May 2024

The objective of this research is to analyze the factors influencing consumer interest in purchasing Tajuk variety onion seeds. The factors affecting consumer purchase interest include content marketing through YouTube, risk perception, and consumer trust. The research method employed is quantitative, with a purposive sampling technique used to select 85 respondents. Subsequently, the analysis results indicate that content marketing through YouTube does not significantly influence consumer purchase interest in Tajuk variety onion seeds. Risk perception does not have a significant effect on consumer purchase interest in Tajuk variety onion seeds. However, consumer trust has a significant influence on the purchase interest of Tajuk variety onion seeds. Furthermore, it is expected that content marketing through YouTube will provide development in the marketing of agricultural products, especially red onions, and through digital marketing media.
Keyword: Content Marketing; Risk Perception; Consumer Confidence; Buying Interest; Shallot Seeds
How Digital Literacy Affects Indonesian Students' Motivation and Interest in Entrepreneurship
Authors: Suprianto* Suprianto , Komara Endang , P. Agung Ign. Wiseto , Fauzzia Willma
Published: May 2024

This study aims to investigate the impact of digital literacy on motivation and interest in entrepreneurship at the Mardira Indonesia College of Information and Computer Management (STMIK). A survey of 100 students was conducted using a quantitative approach. The results showed a significant positive effect of digital literacy on students' entrepreneurial motivation and interest. The implications of this research provide a deeper understanding of the importance of digital literacy in influencing student entrepreneurial attitudes and behaviors in the digital era. The implications of this research include increasing digital literacy awareness, the role of education in developing entrepreneurial skills, developing entrepreneurship coaching programs, and increasing career opportunities and economic independence of students.
Keywords: Digital literacy; Digitalization; Entrepreneurial Motivation; Entrepreneurial Interest; Student’s Motivation
Compensation and Working Time in relation to Employee Performance
Authors: Mulyono Mulyono , Hendarsyah* Decky , Bahri Saiful
Published: May 2024

This research aims to analyze empirically and show the influence of compensation and working time on employee performance. This research uses a descriptive quantitative approach with primary and secondary data sources through questionnaires and literature. The research population was all employees at Meskom Agro Sarimas Company Bengkalis totaling 105 people. The sampling technique used simple random sampling while measuring the number of samples used the Isaac and Michael approach size of 79 people. The data analysis technique uses multiple linear regressions with the help of SPSS software. Before the analysis, validity, reliability, classical assumptions, and hypotheses were tested. The research results show that compensation has a positive effect on employee performance. Working time has a positive effect on employee performance. Compensation and working time simultaneously influence employee performance. Theoretically, this research can complement existing theories. Practically, this research can be used as a reference for companies to improve the performance of their employees, especially in terms of compensation and working time.
Keyword: Employee Performance; Compensation; Working Time; Management; Company
The Challenges of Developing an Indonesian Travel Corridor: Bintan Resorts in Singapore as a Study Case
Authors: Fera Mirta , Muzwardi* Ady , Oktavian Dimas
Published: May 2024

Indonesia has the best international cross-border tourism called Bintan Resorts or better known as Lagoi. The emergence of Covid-19 made the tourism sector in Lagoi slumped. This condition makes Bintan Resorts and tenants, local governments, and the central government strive to revive Lagoi tourism through promotion by using a business diplomacy strategy through a travel bubble approach to attract Singaporean tourists as Lagoi's main target market. This research uses a qualitative method that shows the results that the concept of a travel bubble between Bintan Resorts and Singapore has not been fully implemented. This is because Indonesia's diplomacy has not been followed by domestic policies that are consistent and of the same standard as Singapore. This study argues the need for a middle ground in the form of a mutual agreement, where the Indonesian government can apply all Singaporean requirements as national standards, especially in tourism management.
 Keywords: Economy; Management; Travel Bubble; Business; Building Capacity
Een facet van de diplomatieke cultuur: geloofs-, volmacht-instructie- en vrijgeleidebrieven in het begin van de vijftiende eeuw
Authors: Borchgrave en Bert Verwerft Christian de
Published: May 2024

Résumé. – Un aspect de la culture diplomatique : lettres de créance, de procuration, d’instructions et de sauf-conduit au début du quinzième siècle

La juridification et le recours croissant à l’écrit dans l’administration bourguignonne, ainsi qu’une culture chevaleresque, marquèrent les contours de la diplomatie bourguignonne. La professionnalisation de l’activité diplomatique à l’époque du duc Jean sans Peur (1404-1419) encouragea la spécialisation et la formalisation des documents diplomatiques. Cette contribution offre un éventail des documents diplomatiques les plus usités : lettres de créance, de procuration, d’instructions et de sauf-conduit.
Quand l’État reprend ses droits : Guerre, économie rurale et enquêtes administratives en Flandre au temps de Maximilien d’Autriche (1484, 1495)
Authors: Sablon du Corail Amable
Published: May 2024

La guerre, à l’époque médiévale et moderne, perturbe gravement l’économie et entraîne la suspension du fonctionnement normal des institutions, voire leur effondrement temporaire. Celles-ci, pourtant, ne tardent pas à réagir par la mise en oeuvre de procédures administratives complexes tendant à restaurer leur emprise sur la société. Sont ici présentées deux enquêtes menées par la Chambre des comptes de Lille en 1486 et 1495, la première à la demande du fermier du domaine comtal de Ninove, la seconde sollicitée par le receveur de l’Extraordinaire de Flandre. L’enquête de Ninove livre de précieuses informations sur les conséquences de la guerre sur la démographie, la main d’oeuvre et l’agriculture. On y voit que quelques mois d’opérations militaires suffisent à faire chuter d’un tiers ou de la moitié le produit d’un cycle triennal entier. L’information sollicitée par le receveur de l’Extraordinaire de Flandre, quant à elle, révèle les obstacles que devait surmonter un officier du prince dans l’exercice de ses fonctions. Les deux documents illustrent toute l’importance de la routine dans le développement de l’État : le discours de «rationalité administrative » porté par les Chambres des comptes était en effet rendu performatif non par l’efficacité des procédures de contrôle, mais par leur répétition.
L'orientation dans les techniques du corps chez les Mongols
Authors: Lacaze Gaëlle
Published: May 2024

Orientation refering to the techniques of the body

The Mongol yurt forms a circular area with the fireplace in the centre. Without wall, it opens on the outside through a door and a round skylight that a chimney goes across. For all, the yurt is an area with implicit demarcation lines that divide its internal space in several places distinctively identified. On the contrary, while analysing ways of moving and acting under the yurt, this article sheds light on an area where each category of person, according to their age, gender and social status, has a specific place. Moreover, outside the yurt, in the wide world, techniques of the body are distinct one from the other according to each area and to the passage through some of the limits dividing them, either symbolic or real ones. Indeed, arrangement of the yurt, its position on the camp and likewise the perceptions of the landscape for a part refer to the body. As a result, for the Mongols, the perceptions of the environmental world seem to be dynamic and based on the notion of movement.
Géographie, représentations et utilisations symboliques de l’espace dans les chants chamaniques du Népal de l’Ouest
Authors: Berardi-Tadié Barbara
Published: May 2024

Geography, symbolic representations and uses of space in the shamanic songs of West Nepal

The corpus of shamanic songs belonging to the West Nepal “Dhaulagiri tradition” supplies us with a very rich source of information concerning the spatial perceptions and symbolic representations of the communities living on the Himalayan hills of Nepal. The analysis of these texts highlights the link between geography and group identity, suggesting how the songs represent and reaffirm a bond between the groups and their territories and how the use of spatial categories in the songs reveals these communities’ conception of their own identity. But spatial categories also play a specific role in shamanic action proper, as demonstrated by the songs analysed in the last part of this essay. More generally, a survey of these Nepalese repertories shows how symbolic thought, as expressed in the songs, is largely informed by spatial categories.
Lieux sacrés de la vallée du Haut Iškin (Touva)
Authors: Pimenova Ksenia
Published: May 2024

Sacred sites in the valley of the Üstüü-Iškin (Tuva): oral traditions and ritual practices

This article explores the role played by sacred places and local oral tradition in preserving the collective memory of the inhabitants of the valley of the Üstüü-Iškin (Western Tuva). I distinguish between two particular types of places: those which are ‘positive’ and where rituals are conducted regularly and ‘negative’ places, where harmful spirits roam. For the inhabitants of the valley, each particular place has its own history and specific features, which are embodied in ancient legends and in more recent personal accounts that are narrated and perceived as truth, not as fiction. The truthful aspect of these expressions of oral tradition has made possible the preservation of particular places and the corresponding beliefs, and in this way, of the whole system of relations between man and nature which seems to survive and to manifest itself in the most evident way at the level of small and relatively isolated local communities.
Les Chinois à Kiakhta (1728-1917)
Authors: Petrov Alexandre I.
Published: May 2024

The Chinese in Kiakhta (1728-1917)

This paper considers the vital activities of Chinese in Kiakhta, which, for a long time, together with Maimacheng, served as the only trade gate between Russia and China. It suggests that between 1727-1917, the life of Chinese in Maimacheng, as well as their contacts with Russians in Kiakhta, was strictly regulated by the Chinese government through laws that were unknown to the Russian merchants. Nevertheless these restrictions were not disruptive, and, thanks to Russian hospitality, the Chinese felt at home in Kiakhta and Troitskosavsk. They not only stayed there for a long time for trade, but also went there on visits to Russian friends and to celebrate different festivals. It is significant that at difficult times, for example in struggles with natural disasters, the Chinese and Russians helped each other. The article stresses in particular the period after the signing of the Russian-Chinese treaties in 1858-1860, when Kiakhta lost its exceptional importance, and Russian-Chinese trade was carried out along all perimeters of the border between the two empires. This new trading opportunity was an unexpected turn for Kiakhtian merchants as well as for ordinary traders, who were forced to compete with Chinese “at home.” The article concludes that Kiakhta has played an influential role not only in Russian-Chinese trade, but also in cultural interactions between the Russian and Chinese peoples.
Creating and Evaluating Impact: A Resource for Creative Arts Researchers
Authors: Braae Nick , Brook Lesley
Published: May 2024

The concept of “impact” has grown in currency and prevalence in New Zealand research environments over recent decades. In 2015, the Ministry of Business, Innovation and Employment (MBIE) established the “joint pillars of excellence and impact for the research system.” In a 2019 position paper, MBIE updated this vision, calling for publicly-funded research to maintain “line-of-sight to impact” whereby “each researcher and institution understands their part in the bigger picture – how their activities have or could contribute, directly or indirectly, to the shared endeavour of impact for New Zealand.” Concurrently, The Report of the PBRF Review Panel in 2018 had research impact as a recurring theme, with the authors noting “[the] persistent concerns about the ability of peer review panels to assess the quality of research engagement and impact [...] and the contributions that many researchers make to a vibrant research environment” (p. 62). They suggested that their recommended changes would “place more value on the impact of research” and “provide a more obvious pathway for staff to have the impact of their research recognised” (p. 65). Since then, the Sector Reference Group – responsible for making recommendations to the Tertiary Education Commission (TEC) about the design of PBRF – has established a working definition for research impact: “a positive effect on, change, or benefit to society, culture, the environment, or the economy at any level, outside the research environment” (p. 11). This definition is close to that used by MBIE: “a change to the economy, society or environment, beyond contribution to knowledge and skills in research organisations.” The aim of this publication is to explore how notions of “impact” operate and can be translated into a creative arts research environment.
The Scientific Production of Providing Health Services to the Elderly: A Scientometric Study
Authors: Ouchi Ali , Ezati Elahe , Barati Majid , Ghasemi Vida , Saniee Nadia
Published: May 2024

Introduction: Today, paying due attention to providing primary health services for the elderly is of high importance, and significant studies have been conducted in this regard in the world. The present study aimed to analyze the performance and drawing a scientific map of publications in the field of geriatric health services with a scientometric approach. Methods: In this scientometric study, all the scientific outputs in the field of geriatric health services in the Science Citation Index Expanded (SCIE-Web of Science) in the period from 1980 to August 18, 2023 were included. For data analysis, biblioshiny and Excel software were used. Results: Among 33238 documents in the field of geriatric health services indexed in the SCIE, the most of them were original articles. The growth trend of these documents was increasing so that the lowest number is related to 1987 with two documents and the highest number is related to 2022 with 3315 documents. BMJ Open was the most productive journal and Lancet was the most cited journal in this field. Univ Toronto was the most prolific institution and Cohen AD was the most prolific author. The keywords health services research and epidemiology were the most frequent. Conclusion: By presenting a comprehensive picture of the current state of studies in the field of geriatric health services, this study can determine the direction of future research. In addition, the findings of the present study can guide the direction and effectiveness of the research in this field.
Out-of-Hospital Cardiac Arrest in the Elderly: Unique Considerations and Challenges – A Case Series
Authors: Khazaei Afshin , Afshari Ali , Darabi Fatemeh
Published: May 2024

Introduction: Out-of-hospital cardiac arrest (OHCA) is a significant public health issue. Developed countries have observed an increasing number of OHCAs in the elderly population. Emergency medical technicians (EMTs) are facing a growing number of OHCA cases in elderly patients, requiring special attention and consideration. As of 2020, the latest cardiopulmonary resuscitation (CPR) guidelines prioritize chest compressions as the initial course of action in OHCA situations. Methods: A year-long statistical analysis (2020-2021) of elderly individuals in the pre-hospital system of Hamadan province examined 10 cases of OHCA in the elderly in 2020-21 that occurred after consuming food (postprandial myocardial infarction). Results: Ten of 90 cardiac arrest cases attended by EMTs occurred in elderly individuals after eating, and despite resuscitation efforts by the EMTs, none of these cases were successful. Consequently, this complication significantly reduces the chances of successful resuscitation in these patients. Therefore, addressing the issue of aspiration in elderly individuals during resuscitation is crucial. Conclusion: Continued research, collaboration, and adaptation of resuscitation protocols will contribute to advancements in the field and enhance the life-saving potential of elderly individuals who experience cardiac arrest.
Targeted Hybrid Nanocarriers as Co-Delivery Systems for Enhanced Cancer Therapy
Authors: Erebor Joan Onyebuchi , Agboluaje Elizabeth Oladoyin , Perkins Ava M. , Krishnakumar Megha , Ngwuluka Ndidi
Published: May 2024

Hybrid nanocarriers have realized a growing interest in drug delivery research because of the potential of being able to treat, manage or cure diseases that previously had limited therapy or cure. Cancer is currently considered the second leading cause of death globally. This makes cancer therapy a major focus in terms of the need for efficacious and safe drug formulations that can be used to reduce the rate of morbidity and mortality globally. The major challenge encountered over the years with cancer chemotherapy is the non-selectivity of anticancer drugs, leading to severe adverse effects in patients. Multidrug resistance has also resulted in treatment failure in cancer chemotherapy over the years. Hybrid nanocarriers can be targeted to the site and offer co-delivery of two or more chemotherapeutics, thus leading to synergistic or additive results. This makes hybrid nanocarriers an extremely attractive type of drug delivery system for cancer therapy. Hybrid nanocarrier systems are also attracting attention as possible non-viral gene vectors that could have a higher level of transfection, and be efficacious, with the added advantage of being safer than viral vectors in clinical settings. An extensive review of various aspects of hybrid nanocarriers was discussed in this paper. It is envisaged that in the future, metastatic cancers, multi-drug resistant cancers, and low prognosis cancers like pancreatic cancers, will have a lasting solution via hybrid nanocarrier formulations with targeted co-delivery of therapeutics.
Comparative Effectiveness and Safety of Biologic Treatments in Giant Cell Arteritis: A Network Meta-analysis of Randomized Controlled Trials
Authors: Lee Young Ho , Song Gwan Gyu
Published: May 2024

Background: Drugs containing the 4-anilinoquinazolines scaffold play a critical role in cancer treatment by inhibiting protein kinases, especially tyrosine kinases. In this study, a novel series of 4-anilinoquinazoline derivatives were synthesized and evaluated as cytotoxic agents. Methods: All final compounds were synthesized using two methods, including a conventional approach using potassium iodide and dimethylformamide as well as a green method using a deep eutectic solvent (DES) comprising choline chloride:urea. The cytotoxicity was tested on the A431, HUVEC, and HU02 cell lines. To evaluate the binding pattern of the compounds with EGFR and VEGFR-2, a molecular docking investigation was performed. Finally, the wound healing assay was carried out to assess the potency of compounds in inhibiting cell migration. Results: The final reaction time was approximately 15-20 min with yields of 60-72% using DES, while the conventional method took 3 to 4 h to complete, with yields between 30% and 42%. Compounds 8k and 8l showed better cytotoxicity against both cell lines compared to vandetanib (IC50=0.11 µM and 0.26 µM on A431 and IC50=5.01 µM and 5.24 µM on HUVEC, respectively). Molecular docking studies revealed that compound 8k, which contained 3-methylaniline at the 4-position of the quinazoline core, showed efficient binding affinity to both EGFR and VEGFR-2. An essential hydrogen bond was formed between quinazoline N1 of 8k and the Met796 residue of EGFR with a docking score of -8.76 kcal/mol. The imidazole N3 of 8k interacted with the Cyc919 residue of VEGFR-2, forming a hydrogen bond with a docking score of -9.03 kcal/mol. Moreover, compound 8k exhibited the best inhibitory activity on cell migration and wound healing. Conclusion: Tocilizumab may be the most efficient remission-inducing and relapse-lowering biological agent for patients with GCA, and TNF inhibitors pose the highest risk of infection among the biologics studied.
Biogenic Zinc Oxide Nanoparticles Attenuate Acute Lymphoblastic Leukemia Cell Proliferation through Oxidative Stress and DNA Damage
Authors: Sujatha Venugopal , Venkatesan Alagesan , Sancharan Acharya , Thirunavukkarasu Chinnasamy
Published: May 2024

Background: The most prevalent pediatric cancer is acute lymphoblastic leukemia (ALL). It is exceedingly challenging to treat recurrent diseases, and there aren’t many new medications available for children with disease resistance. The size-dependent anticancer effect of zinc oxide nanoparticles (ZnONPs) on T-cell acute lymphoblastic leukemia (T-ALL) cell line MOLT 3 is the central theme of this study. Methods: The leaf and bark extracts of Diospyros montana were subjected to nanoparticle (NPs) synthesis and characterized analytically to acquire ZnONPs. The ZnONPs were characterized using UV-Vis spectra, DLS, XRD, EDX, SEM, and TEM analysis. Then the ZnONPs were separated into two groups having <50 nm and 50-100 nm NPs sizes. In addition, MTT assay, dual staining, autophagy, DNA damage, and oxidative damage measurement were done to find out the anti-cancer effect of the ZnONPs on MOLT 3 cells. Results: The ZnONPs exhibited a size-dependent anticancer effect against MOLT 3 cells. The IC50 of ZnONPs of < 50 nm was found to be ~75 µg/mL while the IC50 of ZnONPs of 50-100 nm size was found to be ~102 µg/mL. Treatment with ZnONPs of <50 nm size decreased mitochondrial membrane potential, more than that with 50-100 nm ZnONPs. On the other hand, autophagy was found to be more prevalent in 50-100 nm treated ZnONPs when compared with < 50 nm size. However, treatment with both sizes of ZnONPs reduced cell proliferation markers such as ki67 positive cells while increasing 8-OHG and HDCF-DA positive cells. Conclusion: The obtained results portrayed that different-sized ZnONPs induce different modes of T-ALL cell death. Small-sized ZnONPs revealed higher efficacy, highlighting the size-dependent property. Further, this finding denotes that ZnONPs could be an effective anticancer agent against dreadful diseases like T-ALL, warranting further investigation.
Denizli Bakır Kablo Sanayisi Afet Ekonomisi Risk Değerlendirmesi İçin Bir Karar Destek Sistemi Modeli
Authors: Kocatepe Hamza , Ünlü Ören Hidayet Gizem
Published: May 2024

Türkiye bir deprem ülkesidir. Türkiye nüfusunun yaklaşık %95’i deprem tehlikesine maruz kalma ihtimali olan alanlarda yaşamaktadır. Denizli şehri için de doğal afetler arasında en yıkıcı etkilere sahip olan olayın depremler olduğu bilinmektedir. Kablo sektörü ve bakır tel sektörü birlikte değerlendirildiğinde Denizli ihracatının %30,3’ünü oluşturmaktadır. Dolayısıyla bu sektör Denizli’nin ihracatının yaklaşık 1/3 ünü oluşturan ve il için ihracat lokomotifi olan bir endüstridir. Denizli bakır kablo sanayisi afet ekonomisi riskinin değerlendirmesi ve bu kapsamda bir karar destek sistemi modelinin geliştirilmesinin amaçlandığı bu araştırma iki aşamalı çalışmadan meydana gelmektedir. Çalışma-1’de afet ekonomisi riski değişkenlerinin ağırlıkları Analitik Hiyerarşi Süreci yöntemi ile hesaplanmıştır. Tüm kriterler arasında en büyük ağırlık binanın dayanıksızlığına aittir. En küçük ağırlığa sahip olan ağırlık tedarikçinin afet bölgesinde bulunması oranına aittir. Çalışma-2’de ise elde edilen ağırlıklar kullanılarak farklı senaryolara göre değerlendirme alternatifi sunan Web tabanlı dinamik bir karar destek sistemi geliştirilmiştir.
Reasons for stagnation in river transport in Poland at the turn of the 20th and 21st centuries
Authors: Czaja Stanisław , Tutaj Jerzy
Published: May 2024

The aim of the study was to identify the causes of the progressive stagnation in Polish river shipping (Polish inland navigation) since the middle of the 20th century. The methodology used, due to the type of research, was of a complex, eclectic nature. It was based on the analysis of empirical data, desktop research studies, a systemic analysis of relations and cause-and-effect relationships in the sphere of river transportation, and a critical interpretation of the goals contained in program documents on the development of river shipping. The studies focused on the macroeconomic level. The results obtained not only identified the causes of stagnation, but also indicated the most urgent directions for research in this area. Their implementation may allow to design such a strategy for the development of river shipping in Poland, thanks to which it will become an important part of the economy and sustainable transport. The research is original and unknown in this form in the Polish literature.
Sustainable future of construction: the potential of concrete with basalt mini-bars as reinforcement
Authors: Krassowska Julita , Kosior-Kazberuk Marta , Słowik Marta , Akram Amanda
Published: May 2024

The paper concerns the influence of basalt minibars on the subcritical and critical behaviour of test specimens made of concrete with low-emission cement. Low-emission cement produces lower emissions of greenhouse gases and other pollutants than traditional cement. Analyses were conducted on changes in fracture mechanics parameters depending on the content of microfibers in the concrete mix (0, 2, 4, 8 kg/m³), the type of cement used, and the water-to-cement ratio (w/c). It was demonstrated that concrete reinforced with basalt microfibers exhibits increased resistance to crack initiation and propagation. An increase in the stress intensity factor was observed for CEMI 42.5R concretes at w/c=0.5  by 27%, at w/c =0.4 by 62%, and for CEM II 42.5R/A-V concretes at w/c=0.5  by 29%, and at w/c=0.4 by as much as 30%. It was shown that the addition of microfibers to concrete made with low-emission cement significantly increases the mechanical parameters of this material.
Den einen Lehrer*innenmangel gibt es nicht. Ein Diskussionsbeitrag zur Differenzierung
Authors: Gollub Patrick , Zorn Sarah K. , Kruse Christoph
Published: May 2024

Die mediale Berichterstattung, die politische Diskussion sowie der wissenschaftliche Diskurs zum (vermeintlich richtigen) Umgang mit dem Lehrkräftemangel in der Bundesrepublik Deutschland werden zunehmend sehr allgemein und somit verkürzt geführt. Wir möchten dazu anregen, in der mitunter pauschalen Diskussion die Perspektiven auf den Lehrkräftemangel zu differenzieren, um den vielfältigen Problemlagen gerecht zu werden. Wir unterscheiden in der folgenden Darstellung zwischen der räumlichen Dimension, der Differenzierung nach Schulformen und Lehrämtern sowie nach Unterrichtsfächern.
Modificaciones cíclicas a nivel del canal cervical
Authors:   , Redondo Benjamín I.
Published: May 2024

Se tratan los siguientes temas: fisiopatología del cuello uterino, ciclo cervical normal, alteraciones del ciclo.
Los homoinjertos en cirugía plástica de nariz
Authors:   , Rodríguez Iriarte Carlos
Published: May 2024

La reconstrucción de las deformidades en la nariz con esqueleto osteocartilaginoso insuficiente, ha originado para los cirujanos plásticos un sinnúmero de problemas que han sido resueltos en distintas formas. El esqueleto osteocartilagino insuficiente para la armonía de la cara puede ser completado por otro, recién logrado de un ser homólogo que lo presentaba en exceso. Hueso y cartílago, con su articulación sin ser modificado el primero y su unión osteocartilaginos son utilizados a los pocos minutos de ser extraídos de la nariz a la cual por ende y con tal acto quirúrgico se corrige su desarmonía. Se considera que el injerto así logrado se adapta mejor a las exigencias de la naturaleza que cualquier otro.
HIGH SCHOOL TEACHERS' ATTITUDES TO INTEGRATE THE SUSTAINABLE DEVELOPMENT GOALS INTO ENGLISH EDUCATION: AN EMPIRICAL STUDY FROM CHINA
Authors: Wei Yiran , Ishak Nor Asniza
Published: May 2024

This study aims to investigate Chinese high school teachers' attitudes toward integrating the SDGs into English education and examine whether there are differences in terms of gender, age, teaching experience, and professional titles. The study adopted an online purposive sampling survey method and collected 400 questionnaire data, including 381 valid questionnaires. The collected data were analysed using the descriptive and differential analysis methods of SPSS 27. The results found that teachers have lower attitudes towards integrating the SDGs into English education (mean =3.30), with the average score of cognitive attitudes being higher than behavioural attitudes. The overall attitude of female teachers is higher than that of male teachers, that of younger teachers is higher than that of older teachers, and that of teachers with 11-20 years of teaching experience and intermediate professional titles is higher than that of the other two groups. The difference analysis shows that teachers' cognition, behaviour and overall attitude are significantly affected by teaching experience and age, while gender and professional title have little impact on attitudes. Respondents generally cited a lack of understanding of the SDGs and a lack of relevant training and support. Finally, the researchers proposed four suggestions to integrate SDGs into English education effectively.
ASSESSMENT OF WEIGHTED OVERLAY CONFIGURATION PARAMETERS TOWARDS ROUTE SELECTION IDENTIFICATION
Authors: Tuan Mohd Nor Tuan Nur Atikah , Samsudin Sarah Hanim , Ismail Mohd Nadzari , Elias Mohd Azimin
Published: May 2024

Finding the route with the lowest cumulative cost is one of the critical task in utilities management especially in power industries. Selection of the right route is a crucial aspect for identifying the most suitable and low cost path from floating solar photovoltaic system (FSPV) to proposed infrastructure facilities (IF) area that is important to reduce the travel time. The selection process involves several environmental parameters and criteria that play essential role for this route selection. Therefore, this study using ArcGIS Spatial Analyst that offer suitable processing tool that able to deals with raster data. In order to get the suitable path, weighted overlay tool being used to generate the cost surface that later used for computing the path distance and cost distance in the route selection processing. As the purpose of this study is to evaluate how the route selected based on different scenarios, different influence factor percentage and evaluation scale were set during weighted overlay processing environment. Land use type, geological type and slope degree are the three main input used to execute weighted overlay process along with the location of the infrastructure facilities and transmission main intake building. A comparative analysis from the results obtained showed that different influence factor percentage resulting to various least costly path line. However, changing the evaluation scale for the land use data giving discourage result as even the restricted value had been assigned to several land use type, the route selection did not avoid the restricted areas. To conclude from all the findings, No Data value should be assigned to the land use type to be excluded in the scale value instead of using restricted value in order to get the best route selected that avoid the restricted areas.
HUBUNGAN INTERNET ADDICTION DENGAN NYERI LEHER PADA REMAJA DI SMA NEGERI 3 PALANGKA RAYA
Authors: Wiyono Henry , Ronaldo Ferry , Riana Dewi Christin
Published: May 2024

Latar Belakang: Nyeri leher merupakan dampak negatif yang ditimbulkan dari penggunaan internet yang berlebihan. Penggunaan internet yangberlebihan sering kita kenal dengan istilah internet addiction. Internet addiction merupakan perilaku adiktif yang ditandai dengan ketidakmampuanindividu dalam mengendalikan kebutuhannya dalam menggunakan internet. Remaja merupakan individu yang masih berada pada tahap perkembangan sehingga lebih rentan untuk mengalami internet addiction. Fenomena yang terjadi saat ini adalah adanya peningkatan kejadian internetaddiction pada kalangan remaja. Tujuan: Untuk mengetahui hubungan internet addiction dengan nyeri leher pada remaja di SMA Negeri 3 PalangkaRaya. Metode: Teknik pengambilan sampel menggunakan total sampling didapatkan 111 responden, pengambilan data menggunakan kuesionerIAT dan NDI yang sudah melalui uji validitas dan reliabilitas, untuk analisis data menggunakan uji statistik Spearman Rank. Hasil: Berdasarkan hasiluji statistik dengan metode Spearman Rank menunjukkan angka Sig. 2-tailed dengan nilai p-value 0,00 dengan derajat kemaknaan p kurang 0,05 yangartinya ada hubungan antara internet addiction dengan nyeri leher. Correlation Coefficient didapatkan hasil 0,616 yang artinya memiliki tingkatkeeratan hubungan tinggi dan kuat. Terdapat arah hubungan yang positif antara internet addiction dan nyeri leher yaitu 1,000 lebih 0,616 yang artinya semakintinggi kejadian internet addiction maka kejadian nyeri leher juga semakin meningkat. Sehingga H1 diterima, artinya ada Hubungan Internet Addictiondengan Nyeri Leher. Simpulan: Ada hubungan antara internet addiction dengan nyeri leher. Disarankan kepada pihak instansi agar lebih sering memberikan konseling atau sosialisasi kepada siswa-siswi mengenai dampak negatif yang ditimbulkan akibat kecanduan internet, baik dampak yangmengarah kepada fisik, psikologi dan lingkungan sekitar.
Analyzing Sustainable Design in Post-Pandemic Business Space Planning from Consumer Perspective
Authors: Huang Chun-Pin , Huang Chia-Hui , Chen Chun-Chih
Published: May 2024

The pandemic brought transformations in daily life and societal structures. It has impacted the design and planning of commercial spaces. Commercial spaces, serving as the direct interface with consumers, have played a more pivotal role recently. Consumer viewpoints and demands have been changed beyond comfort and convenience to mitigate concerns related to sustainable development and health. From the consumer perspective, we explored the key factors for the sustainable design of commercial spaces in the post-pandemic era. Kansei engineering, factor analysis, and the Kano model were used to identify dimensions, namely safety and comfort, community engagement and sustainability, environmental conservation and resource efficiency, as well as technological integration and waste management. Consumers expect commercial spaces to provide safety measures, adequate ventilation, hygiene and cleanliness, green landscapes, personalized services, and social distancing arrangements to create a pleasant and secure environment. Additionally, they are concerned about whether commercial spaces actively engage with the community, promote sustainable development, and prioritize energy efficiency. The result contributes to the optimization and sustainable development of commercial spaces. By comprehending consumer perspectives, companies can overcome the challenges of the post-pandemic era, innovate in the design of commercial spaces, and create business environments that are more appealing and aligned with consumer expectations.