bluuebunny/crossref_metadata_2025 huggingface dataset:
Okul Yöneticilerinin Anlam Yaratma Yeterlikleri Ölçeği’nin (OYAYYÖ) Geliştirilmesi: Geçerlik ve Güvenilirlik Çalışması
Authors: DİŞ Okan , DEMİRKASIMOĞLU Nihan
Published: May 2023

Bu araştırmanın amacı, okul yöneticilerinin anlam yaratma yeterliklerine ilişkin öğretmen algılarını ölçmeye yönelik geçerli ve güvenilir bir ölçme aracı geliştirmektir. Araştırma kapsamında alanyazından ve öğretmenlerle yapılan görüşmelerden faydalanılarak madde havuzu oluşturulmuş ve kapsam geçerliği için uzman görüşüne başvurulmuştur. Araştırmanın verileri 2021-2022 eğitim öğretim yılında Milli Eğitim Bakanlığına bağlı kamu ilkokul, ortaokul ve liselerde görev yapan 626 öğretmenden oluşan iki farklı çalışma grubundan toplanmıştır. Verilerin çözümlenmesinde madde analizi, açımlayıcı faktör analizi, birinci ve ikinci düzey doğrulayıcı faktör analizi yapılmış ve güvenirlik katsayıları hesaplanmıştır. Madde analizi ve açımlayıcı faktör analizi sonucunda toplam 26 madde ve dört alt boyuttan oluşan bir ölçek elde edilmiştir. Ortaya çıkan alt boyutlar bilişsel süreçler, etkili iletişim, değişime uyum ve kriz yönetimi olarak adlandırılmıştır. Doğrulayıcı faktör analizi sonucunda elde edilen bulgular ölçeğin kabul edilebilir bir uyuma sahip olduğunu göstermiştir. Ölçeğin güvenirliği için .86 olarak hesaplanan Cronbach Alfa iç tutarlık katsayısı ölçeğin oldukça güvenilir olduğunu ortaya koymuştur. Bu bulgulara göre, Okul Yöneticilerinin Anlam Yaratma Yeterlikleri Ölçeği’nin geçerli ve güvenilir bir ölçme aracı olduğu belirlenmiştir.
Sınıf Öğretmenleri, İlkokul Öğrencileri ve Velilerin Çocuk Kitabı, Oyuncak Kitap ve E-Kitaba Yönelik Metaforik Algıları
Authors: GÖZÜKÜÇÜK Meral
Published: May 2023

Öğrencilerin kitap okuma alışkanlığı kazanmasında ailelerin ve öğretmenlerin önemli sorumlulukları vardır. Bu sebeple eğitimin bütün paydaşları düşünüldüğünde özellikle öğrenci, öğretmen ve velilerin kitaba yönelik algılarını belirlemenin önemli olduğu vurgulanabilir. Bu bağlamda, yapılan çalışmanın amacı çocuk kitabı, oyuncak kitap ve e-kitap kavramlarına yönelik sınıf öğretmenleri, ilkokul öğrencileri ve velilerin metaforik algılarını belirlemektir. Bu araştırma olgubilim deseninin kullanıldığı nitel bir çalışmadır. Araştırmanın çalışma grubunu sınıf öğretmenleri (n=75), ilkokul öğrencileri (n=135) ve ilkokul öğrencilerinin velileri (n=170) olmak üzere toplam 380 kişi oluşturmaktadır. Sınıf öğretmenleri, ilkokul öğrencileri ve velilerin çocuk kitabı, oyuncak kitap ve e-kitaba yönelik geliştirdikleri metaforlara göre oluşturulan kategorilerin on tanesinin ortak olduğu, bu kategorilerin “beceri, eğlence, bilgi, öğretim, temel, doğa, sosyal, gizemli, iletişim, teknik kaynak” şeklinde olduğu görülmektedir. Sınıf öğretmenleri, ilkokul öğrencileri ve velilerin ortak metaforlar geliştirdikleri, bazı metaforların ise katılımcı grubuna ve çocuk yayınları türleri içerisinde yer alan kitap, e-kitap, oyuncak kitap kavramlarına göre farklılaştığı görülmektedir. Katılımcıların çocuk kitabına ve oyuncak kitaba yönelik olumlu metafor geliştirdikleri ancak e-kitaba yönelik hem olumlu hem de olumsuz metafor geliştirdikleri görülmektedir. Yapılan bu çalışmanın sonuçlarına göre sınıf öğretmenleri ve velilerin çocuk kitabı ve oyuncak kitap konusunda daha olumlu bir algıya sahip oldukları ve bu kitapları ilkokul öğrencileri için e-kitaba göre daha çok tercih ettikleri ifade edilebilir. Ayrıca katılımcıların çocuk kitabı, oyuncak kitap ve e-kitap kavramlarına ilişkin oluşturdukları metaforlar incelendiğinde çocuk edebiyatına yönelik farkındalıklarının olduğu görülmektedir.
Cause of Damage to the Windings of the 6 kV 500 kW Motors Installed at the Water Intake Pumping Station
Authors:   Politechnika Gdanska, KARKOSINSKI Dariusz , LUSZCZ Jaroslaw ,   Politechnika Gdanska, OLESZ Marek
Published: May 2023

The article presents a measurement study of the causes of damage to medium-power and medium-voltage motors used to drive water intake pumps for the city. The user of the pumping station used a low-voltage frequency converter to regulate the pump output, which was powered by a 6/0.4 kV transformer. The voltage behind the converter was increased via a 0.4/6 kV transformer and powered the pump motors via cable lines. Within 2 years from the implementation of converter the insulation of the winding front connections have been damaged in 3 motors. It appears that the permissible instantaneous voltage was almost twice exceeded.
High-Throughput RNA Extraction on Agilent Bravo v1
Authors: R Simon Miriam
Published: May 2023

Extracting bulk-RNA from biospecimens is a time-consuming process. Column-based extractions performed by hand must be done in batches and the number of samples that can be extracted per batch is dependent on a single person's abilities. Hence, extraction hundreds of samples can take weeks. With every round of extractions, reagents are susceptible to differing amounts of contamination and technical error, resulting in batch effects. Microbial RNA input for metagenomic next-generation sequencing is often found in very low quantities; therefore, contamination introduced during extraction may influence sequencing results and depict an inaccurate reflection of microbes present in the original sample. Here, we outline a high-throughput, semi-automatic method to extract RNA using a Agilent Bravo liquid handler. This protocol utilizes a magnetic bead-based approach to extracting RNA and is performed in 96-well deep-well plates. All reagents are plated into 96-well deep-well plates before the start of the Bravo protocol. The liquid handler is programmed to aliquot, mix, and aspirate reagents from different decks of plates. The user is only responsible for putting these plates on the correct decks. With this approach, we can extract a full plate of 96 samples within a day and reduce the susceptibility to contamination from user error.
Ensuring the Cultural Rights of Kurdish Minority in Türkiye: Necessity, Challenges, Solutions
Authors: Fazaeli Mostafa , Karami Mousa
Published: May 2023

Being in non-dominant position and forming one of the largest ethnic groups numerically in Türkiye (previously Turkey), Kurds constitute an ethnic minority. The main argument of this article is that neglecting and disrespecting the cultural rights (CRs) of this group has led to transformation of a social challenge to a political one which ultimately resulted in a security challenge through an armed movement by P.K.K. in the 1980s. Employing a descriptive-analytical method to analyse the content, the present article aims at investigating the necessity of, challenges to and solutions for ensuring CRs of Kurdish minority. It appears that ensuring the cultural rights of Kurdish minority in Türkiye is a pressing necessity particularly for preserving cultural diversity as the common heritage of humanity and maintaining national, regional and international peace and security. Furthermore, the main challenges with which ensuring CRs of Kurds in Türkiye is facing are weak international belief in cultural rights, lack of sufficient national and international monitoring bodies and effective enforcing mechanisms, and dominance of Kemalism as the founding ideology of Republic of Türkiye. Accordingly, the solutions for eliminating these challenges can be strengthening the foundations and developing the sources of cultural rights of ethnic minorities, activating the national and international monitoring bodies and criminalising certain examples of violations of cultural rights and predicting effective sanctions. No article has been written on the necessity of, challenges to and solutions for ensuring the CRs of Kurdish minority in Türkiye in a single piece. Addressing these factors from the perspective of CRs as human rights, this article contributes in filling the existing gap in literature in this regard.
SPACE-ANALYSIS OF THE ENTREPRENEURIAL UNIVERSITIES IN UKRAINE
Authors:   Taras Shevchenko national University of Kyiv, Bilokrynytska S.
Published: May 2023

The world trend of entrepreneurship development has not passed over Ukraine and is increasing its significance with the participation of universities. The research studies entrepreneurial universities and their role in the region and the country’s economy. The research demonstrates that there is no standardized approach to defining an entrepreneurial university and its main characteristics. Given the above, we have defined the meaning of an entrepreneurial university based on the methodology, including its role in the country. The rankings of the leading universities in Ukraine were analyzed so that the mutual features could be set. The research has proved the main hypotheses about the effectiveness of the implementation of the entrepreneurial universities model based on the indexes and rankings, which estimate their academic, research, and publishing activity. Based on the research results, some universities in Ukraine were defined as the ones whose functioning model is close to that of an entrepreneurial university. Three leading Ukrainian universities were assessed using the main criteria of their financial activity, competitiveness, and the sector’s attractiveness. Based on SPACE-analysis, development strategies for domestic entrepreneurial universities were determined. As a result, the practices should ensure innovation implementation, contribute to higher education and secure competitive positions.
THREATS TO FINANCIAL SECURITY OF BUSINESS ENTITIES AND WAYS TO PREVENT THEM
Authors:   Taras Shevchenko national University of Kyiv, Varnalii Z. , Mehed А. ,   Taras Shevchenko national University of Kyiv
Published: May 2023

Enterprises are forced to conduct business in the turbulent exogenous and endogenous environment. This poses threats to financial security at the microlevel, both of cyclical and non-cyclical origin. The paper aims to identify threats to Ukrainian enterprises’ financial security and propose directions for minimizing financial security threats on the micro-level. The paper considers a set of actors of exogenous and endogenous environments that affect the state of financial security at the micro-level. Analysis of groups of stakeholders in the context of financial security is carried out. It is emphasized that changes in the enterprises’ financial security have consequences at both micro- and macro-level. The key drivers of financial and market nature that affect financial security are considered. The exogenous and endogenous environment influences were considered as set of factors of economic, demographic, socio-cultural, legal, and organizational nature. The paper studies a set of micro-level quantitative and qualitative indicators that affect financial security. The importance of accounting for industry and enterprise-specific characteristics in financial security analysis is emphasized. Analysis of financial security through the prism of Ukraine’s real sector finance is carried out. It is highlighted that there are issues of the declining weight of stable financing sources, as well as an issue of a lesser focus on non-current assets in the context of deteriorating financial security. The importance of combining short- and long-term measures of both financial and market nature under the framework of financial security is emphasized. An algorithm for analyzing the state of an enterprise’s financial security is proposed. A set of short- and mediumterm time horizon measures has been formed to maintain adequate financial security at the micro-level. It is suggested to include a key indicator of financial security into them as of strategic goals, i.e., Balanced Scorecard, for economic turbulence period usage.
METHODOLOGICAL APPROACH TO THE ORGANIZATION OF HEALTH TOURISM ON THE EXAMPLE OF THE PRIVATE ENTERPRISE "WHITE ACACIA", ODESA, UKRAINE
Authors:   Odesa National University of Technology, Odesa, Ukraine, Lebedieva Vira , Shekera Svitlana ,   Odesa National University of Technology, Odesa, Ukraine
Published: May 2023

Purpose. The purpose of the article is to analyze the features of medical and health tourism as a specialized type, institutions that specialize in this type, as well as the development of proposals for supplementing the range of services at the "Bila Acacia" medical and health care complex, Odesa, Ukraine. Methods. The research was carried out using general scientific methods, namely, the main methods of research in the article are the method of analysis, synthesis and analytical. The information base of the study is the scientific works of domestic and foreign specialists specializing in medical and health tourism, as well as Internet resources and information presented by the PP Medical and Health Complex "Bila Akatsia". Results. In the course of the research, it was found that medical and health tourism in Ukraine has great potential both in the resource context and in the scientific approach. However, due to the lack of funding, the low level of popularization of this direction, the industry is not competitive with foreign complexes. Post-Soviet health centers are being transformed into multifunctional modern medical and health centers using the leading experience of other countries. Analyzing the activities of the "Bila Akatsiya" medical and wellness complex, a wide range of services was revealed, which involved a complex of healing water and mud sources, and measures were proposed to expand the range and increase the competitiveness of this institution. Scientific novelty. The activity of the "Bila Akatsia" medical and health center as one of the leading health centers in the Odesa region is analyzed. The main physico-chemical properties of therapeutic water and mud, which are the main advantage for this enterprise, have been revealed. Proposals have been made to expand the range of complex services. The practical significance of this article is determined by the possibility of using the research results in the operational activities of the "Bila Akatsia" medical and health complex, other medical and health complexes, and within the educational process by students of the 242 "Tourism" specialty.
Personal Data of the Patient and His Legal Representative: The Specifics of Electronic Provision in the context of the Use of «Artificial Intelligence» Technologies in Digital Medicine
Authors: Poduzova E. B.
Published: May 2023

Artificial intelligence technologies are widely used in digital medicine, in particular, they are used to process personal data of patients and their legal representatives. Personal data refers to the Big Data information. Certain gaps have been identified in the regulation of relations related to personal data. The following problems do not have an unambiguous solution in the doctrine and law enforcement practice: the legal nature of personal data, the legal qualification of consent to the provision and processing of personal data, the content of such consent, the minimum age for its independent expression. The paper examines these problems and suggests ways to solve them. In particular, it is substantiated that consent to the provision and processing of personal data is a civil transaction, the minimum age for expressing such consent is the age of acquiring full legal capacity (18 years). When writing the article, the author relied on the current legislation, civil doctrine, and law enforcement practice.
The Concept of Legal Regulation of Medical Activities
Authors: Mokhov A. A.
Published: May 2023

The paper is devoted to the study of the main problems of legal regulation of medical activity in modern conditions. The author explains problematic aspects of organizational, legal, and doctrinal nature. The author highlights that medical activity as a separate group of economic relations can and should become a starting category for regulating close, but not identical, groups of legal relations in healthcare. The author proposes the main outlines of a possible concept of legal regulation of medical activity. The author elucidates his standing concerning the complex system of legal regulation of medical activity, its irreducibility to the subject field of medical services or medical care. The legitimization of medical activity involves the development of general, specific, as well as special (extraordinary) legal regimes for its implementation. The approach to the legal regulation of medical activity as a separate branch (field) of the economy (based on the totality of its economic, social and other effects), in the author’s opinion, allows us to form a consistent system of legislation regulating medical practice and healthcare legal relations in general.
Right to Self-Determination of Peoples and the Emerging World Order
Authors: Kagramanov A. K.
Published: May 2023

In the paper, the author attempted to reveal the influence of the idea of self-determination on the emerging (in the historical and legal context) world order, taking into account the rapidly developing political and legal processes in the 18th-21st centuries. Attention is given to the use of the relevant law by certain states in their national interests, which, in the conditions of instability of the international system, makes self-determination an object of numerous influences, interpretations and restrictions. Considering cases from international practice and documents, the author concludes that over the centuries the concept of self-determination has undergone many transformations and was considered as a tool for redrawing the borders of Europe in the early and middle of the 19th century, after the end of the First World War and before the collapse of the USSR and Yugoslavia. As a mechanism of decolonization, and at the turn of the 20th–21st centuries — as a tool for fragmenting the political map of the world using the ethnic factor as a basis. Quite interesting are the conclusions about the impact of the institution of human rights, remedial secession, external and internal forms of self-determination, globalization processes on the development of the relevant law. The paper, along with other examples, examines the impact of real politics and the existence of double standards when considering issues of international legal recognition of Kosovo in the event of secession from Serbia and the annexation of Crimea to the Russian Federation.
Fundamental Investigations of Propagation through the Land–Air–Water Interface in a Controlled Littoral Environment
Authors: Swearingen Michelle E. , Taylor Oliver-Denzil S. , Lester Alanna , Stehno Abigail , White Michael J. , Woodley Christa M. , Urbanczyk Aaron C. , Taylor Mihan H. M.
Published: May 2023

Interpreting signals from mechanical waves that cross material media boundaries is challenging due to the historical development of instrumentation suitable to study waves in each distinct medium, leading to discrepancies in boundary and adjacent media descriptions and governing physics related to each media. Nowhere is this more significant than in littoral zones at the convergence of land–air–water (LAW) domains. In short, a comprehensive physics framework does not exist that can accurately predict how waveforms freely traverse these media boundaries resulting in a critical fundamental science knowledge gap that can correlate received waveforms to actual source generators. Furthermore, the preponderance of research has treated media boundaries as lossy reflectors rather than poor transmitters, resulting in a rudimentary understanding of wave transformation over subsurface inhomogeneities and boundaries. This article details the experimental component of a new transdisciplinary effort to characterize the full LAW wavefield within a littoral zone to overcome the mixed media challenges. The fusion of disciplines, including air and underwater acoustics, geophysics, and hydrology, aims to develop a full-wavefield description of coupled media in the environment. Beginning with a simplified scenario, the experimental design accommodates for measurements of wave transmission across land–water, air–water, and land–air boundaries in a controlled, constructed, and prototypical littoral zone. This article reviews the test site design, construction, and preliminary experimental results. The challenges of designing and implementing an experiment that explicitly observes signal propagation across the media boundaries without distorting the boundaries and includes sources and sensors in all three environments are discussed.
Tailoring the Treatment of Early-stage HER2-positive Breast Cancer: One Size Does Not Fit All
Authors: Schlam Ilana ,   Department of Hematology and Oncology, Tufts Medical Center, Boston, MA, USA, Tarantino Paolo ,   Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA,   Division of New Drugs and Early Drug Development, European Institute of Oncology IRCCS, University of Milan, Milan, Italy, Waks Adrienne ,   Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Tolaney Sara M ,   Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Published: May 2023

Human epidermal growth factor receptor-2 (HER2)-positive breast cancer accounts for 15% of all breast cancers and this cancer subtype was historically associated with poor outcomes. The development of HER2-directed therapies has dramatically improved outcomes for patients with early and advanced HER2+ disease. Trastuzumab is a HER2-targeted monoclonal antibody first approved for the treatment of advanced breast cancer in the late 1990s. Since then, it has been shown to improve long-term outcomes for patients with early-stage disease, particularly when given in combination with chemotherapy in the (neo)adjuvant setting. Pertuzumab is another monoclonal antibody that targets a different domain of the HER2 receptor from trastuzumab and prevents HER2–HER3 dimerization. The addition of pertuzumab to trastuzumab and chemotherapy improved long-term outcomes for patients with advanced disease; this drug has also been studied in the (neo)adjuvant setting and proved to improve long-term outcomes for patients with lymph node involvement. Neratinib and trastuzumab emtansine in the adjuvant setting have been shown to improve outcomes for selected high-risk patients. As more effective treatment options have been developed for the treatment of HER2+ breast cancer, we have progressively moved from a one-size-fits-all approach towards a tailored paradigm. In this narrative review, we summarize the diagnosis and prognosis of early-stage HER2+ breast cancer, as well as current treatment approaches.
Durvalumab: A PD-L1 Blocking Antibody for the Treatment of Adult Patients with Locally Advanced or Metastatic Biliary Tract Cancer
Authors: Mahipal Amit ,   Department of Oncology, Mayo Clinic, Rochester, MN, USA,   Department of Oncology, University Hospitals Seidman Cancer Center and Case Western Reserve University, Cleveland, OH, USA, Palmer Mathias ,   Department of Oncology, Mayo Clinic, Rochester, MN, USA, Gile Jennifer ,   Department of Oncology, Mayo Clinic, Rochester, MN, USA, Kim Richard ,   Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA
Published: May 2023

Biliary tract cancers (BTCs), comprising intrahepatic, hilar and extrahepatic cholangiocarcinoma and gallbladder cancers, are associated with poor prognoses. The majority of patients present with advanced-stage disease, and systemic treatment remains the mainstay of treatment. Recently, multiple targeted therapies have been approved by the US Food and Drug Administration (FDA), including pemigatinib, infigratinib, futibatinib and ivosidenib for patients whose disease has progressed on first-line systemic therapy. However, there has been no improvement on the first-line systemic therapeutic regimen of gemcitabine and cisplatin chemotherapy in more than a decade. Recently, durvalumab in addition to gemcitabine plus cisplatin was approved by the FDA as a first-line treatment option for patients with advanced BTC based on the TOPAZ-1 trial. The TOPAZ-1 trial was a phase III double-blind, placebo-controlled trial that enrolled 685 patients into a durvalumab plus gemcitabine plus cisplatin arm or a gemcitabine plus cisplatin arm. The trial demonstrated that the addition of durvalumab to standard-of-care chemotherapy was associated with improvement in median overall survival (12.8 versus 11.5 months), progression-free survival (7.2 versus 5.7 months) and response rates (27% versus 19%). The incidence and severity of adverse events were similar in both groups. Durvalumab in addition to gemcitabine plus cisplatin has become the new standard-of-care treatment for patients with advanced BTCs. This article reviews the immunotherapeutic options for patients with BTCs, describes the studies that led to the TOPAZ-1 trial, and summarizes key areas of research that are necessary to inform future drug development and improve patient outcomes.
The Evolving Therapeutic Landscape and Role of Enfortumab Vedotin in Advanced Urothelial Carcinoma: A Systematic Review
Authors: Talukder Rafee ,   Department of Medicine, Division of Oncology, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA, Makrakis Dimitrios ,   Department of Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY, USA, Grivas Petros ,   Department of Medicine, Division of Oncology, Fred Hutchinson Cancer Center, University of Washington, Seattle, WA, USA, Khaki Ali Raza ,   Department of Medicine, Division of Oncology, Stanford University, Stanford, CA, USA
Published: May 2023

The therapeutic landscape in advanced urothelial carcinoma (aUC) has been rapidly evolving over the last 6 years. Enfortumab vedotin (EV) is an antibody–drug conjugate that targets Nectin-4, which is widely expressed in UC. EV is approved by the US Food and Drug Administration for patients with aUC refractory to prior therapy. EV is now being investigated in combination with other therapeutic agents, such as immune checkpoint inhibitors, both in first-line and refractory settings in aUC as well as earlier therapy settings. In this review, we summarized the role of EV in the rapidly evolving therapeutic landscape of aUC.
Pan-RAF Inhibitors for Paediatric Low-grade Gliomas Offer New Opportunities in Targeted Therapy
Authors: Ziegler David S ,   Kids Cancer Centre, Sydney Children’s Hospital, Randwick, NSW, Australia,   Children’s Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney, Sydney, NSW, Australia,   School of Clinical Medicine, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW, Australia
Published: May 2023

Low-grade gliomas are the most common brain tumour to occur in childhood. The identification of the mitogen-activated protein kinase pathway as the near-uniform driver of these tumours has led to the testing of therapies targeted at this pathway, with promising early results. The pan-RAF inhibitor tovorafenib is one of the most recent targeted agents to be tested for paediatric low-grade gliomas, with early data raising the prospect that we may be at the dawn of a new era in the management of this childhood brain tumour.
Teclistamab Monotherapy for the Treatment of Adult Patients with Relapsed and Refractory Multiple Myeloma
Authors: Razzo Beatrice M ,   Abramson Cancer Center and Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, Garfall Alfred L ,   Abramson Cancer Center and Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Published: May 2023

Several new drugs and regimens have greatly improved outcomes in multiple myeloma, but the rapid emergence of new targets and immune-based modalities has added significant complexity to the management of relapsed and refractory multiple myeloma (RRMM). Teclistamab is a T cell-redirecting anti-CD3 × anti-B cell maturation antigen bispecific antibody recently approved as monotherapy against RRMM. The drug is now the fourth B cell maturation antigen-targeting agent commercially used in RRMM and the third different drug class and mechanism of action doing so. Although approved as a single agent in relapsed and refractory disease, preclinical and clinical evidence has supported teclistamab-based regimens for use in earlier lines or in combination strategies. The identification of novel suitable cell-surface targets in multiple myeloma and the promising efficacy seen in early-phase studies represent additional innovations to the treatment paradigms for RRMM.
Communication is a Public Health Strategy
Authors: Zimmerman Tracy
Published: May 2023

At a time when people are losing faith in public institutions, trust in the North Carolina Department of Health and Human Services is high. Using North Carolina’s pandemic journey as a communication case study offers lessons for public health leaders. This article shares communication elements that helped build trust and provides recommendations.
A Conversation with Rose Hoban, Executive Editor of North Carolina Health News
Authors: Hoban Rose
Published: May 2023

The recent pandemic highlighted a critical lack of trust in health information and the need for better ways to communicate health and safety news and recommendations to the general public. Rose Hoban, executive editor of the nonprofit online publication North Carolina Health News, discusses her experience and recommendations.
Medical Simulation: The Missing Link in Achieving Safer, More Cost-Effective Care
Authors: Joyner Benny L.
Published: May 2023

Medical simulation is an educational strategy in which a par­ticular set of conditions is created or replicated to resemble authentic situations that are possible in real life. In this commentary we discuss how simulation is used and how it can reduce medical error, improve teamwork and communi­cation, and improve trust in the health care system.
Süleyman Beyoğlu, MİLLÎ MÜCADELE KAHRAMANI GİRESUNLU OSMAN AĞA, Bengi Yayınları, İstanbul 2009, 400 s., ISBN: 978-9944-0491-4-6.
Authors: KILIÇASLAN Emre
Published: May 2023

KİTAP DEĞERLENDİRME/BOOK REVIEW

Süleyman Beyoğlu, MİLLÎ MÜCADELE KAHRAMANI GİRESUNLU OSMAN AĞA, Bengi Yayınları, İstanbul 2009, 400 s., ISBN: 978-9944-0491-4-6.
A study of antibody response to Covid-19 infection
Authors: Jain Swapnil , Diwan Ashish , Singh Ravendra , Julka Arti
Published: May 2023

: The Coronavirus disease 2019 is a disease caused by the etiological agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was a newly identified β-coronavirus that had spread rapidly around the world, resulting in a very high number of infections and deaths, threatening public security, and placing a heavy burden on global healthcare systems and economy. The present study was done to study antibody response in COVID-19 infection.

: The study was carried out in the Department of Respiratory Medicine, R.D. Gardi Medical College, Ujjain, India after approval by ethics committee. The post COVID-19 cases attending respiratory medicine OPD were included in the study.

: The present study was conducted in 122 patients. The mean age of the patients was 51.20±14.21 years, median age was 54.5 years, the minimum age was 14 years and the maximum age was 80 years, the most number of COVID-19 infection cases was in the elderly age group of more than 50 years. The severity of disease was seen in those above 50 years of age (57.3%) with p>0.05. Among the severe cases mean age of the cases was 49±17 years, in moderate cases mean age 52±14 and among mild group of cases mean age was 51±15 years.

In the present study there were 73.8% males and females were 26.2% Among COVID-19 cases who reported in the OPD the maximum that is 86 (>70%) patients had moderately severe disease, while severe cases were only about 14 %. Mild cases were 15.6%.

In the present study RT-PCR were negative in 36(29.5%) as against 86 (70.5%) were confirmed cases of COVID-19 and among positive cases 40 % cases became negative between 6-10 days

Among severe disease cases mean SARS COV2 antibody 650.06±240.47 was significantly higher as compare to moderate cases 461.49±331.41 and mild cases 404.11±240.47.

: India has the world’s largest vaccination program. COVID-19 antibodies estimation are important tests carried out to determine the response of the body against COVID-19 infection.

Our results show a significant association between SARS COV2 antibody and the severity of disease.
Food allergen sensitivity in atopy
Authors: Manohar Midhun , Anuja R
Published: May 2023

Atopic symptoms are a commonly encountered presentation the pulmonology, dermatology and medical outpatient visits. Identification and avoidance of the precipitating factors is important in the management of these patients.

Clinical history usually doesn’t give a complete picture of the spectrum of allergen sensitivity. Skin prick Test is described as a safe technique in identifying some obscure precipitating factors that might be worsening the clinical scenario.

This is a 6 month cross sectional study conducted in a research institute in central Kerala among 31 chronic urticaria patients during May to October 2022. Skin prick testing with 30 common food allergens was done.

Among the 31 subjects studied 26 (83.87 %) had allergy to foods (90 % among males and 80 % among females). Dal Urud (35.35 %) was the found as the most frequent food allergen, followed by pea (25.8 %), fish, rice and wheat (22.7%).

Dal Arhar, Milk and fennel seeds were found to be the least common food allergens.

Apart from minor itching and redness, none of the subjects developed significant reactions following the test.

This study underlines the importance and safety of skin prick testing in patients with chronic uricaria. In this study it was found that more commonly used foods in Kerala like rice, dal urud were more sensitive.
Comparative evaluation of marginal microleakage of various restorative materials used in pediatric dentistry – An in-vitro stereomicroscopic study
Authors: Iftikhar Nahid , Dixit Shalini , Salman Ali , Do Minh Tuan
Published: May 2023

The longevity of restorative materials depends on the resistance to masticatory forces. The present study was undertaken to evaluate the microleakage properties of different restorative materials.

A total of 30 specimen blocks were prepared with 10 samples of each type of restorative material, namely GIC Fuji IX, Filtek Z-350 Composite, and Cention-N. Class I cavities were prepared with dimensions 1.5 x 2 x 2 mm (l x b x h) of cavity size of orthodontically extracted premolars followed by restoration of each test material.

We found thatCention-N has shown the least microleakage as compared to other groups.

Mean microleakage was the least for Cention-N. It’s a newer restorative material having higher mechanical properties with lesser microleakage.

Cention-N is a newer restorative material having promising properties. This material can be used as an alternative restorative material.
Prevalencia y factores asociados a sobrepeso y obesidad en docentes de una universidad pública de Popayán- Colombia en 2021
Authors: Ramos-Valencia Omar Andrés , Buitron-Gonzalez Yuliana , Aristizábal-Grisales Juan Carlos , Villaquiran-Hurtado Andrés Felipe
Published: May 2023

Introducción: la prevalencia de la obesidad sigue en aumento a nivel mundial, lo que se traduce en un mayor riesgo para adquirir enfermedades no trasmisibles. Los factores de riesgos modificables que contribuyen a este problema, se asocian a situaciones laborales en cuyas condiciones de trabajo existe bajo dinamismo musculoesquelético. El objetivo de este estudio fue determinar la prevalencia y los factores asociados a la obesidad y el sobrepeso en docentes de una universidad pública del departamento del Cauca, Colombia en 2021. Metodología: estudio cuantitativo, de corte transversal; se seleccionaron 256 docentes. Se excluyeron profesores en periodo postquirúrgico abdominal reciente o con liposucción de abdomen. Se aplicó una encuesta indagando sobre datos sociodemográficos, conocimiento sobre obesidad y sobrepeso, hábitos y medidas antropométricas. Se realizó análisis descriptivo, pruebas de Chi cuadrado y regresión logística múltiple. Resultados: 47,7% de los docentes fueron clasificados con sobrepeso; 49,6% manifestó consumir bebidas alcohólicas; 18,4% presentó alto riesgo de enfermedad cardiovascular y 48,4% se encontraba en riesgo de presentar síndrome metabólico. Por su parte, los docentes hombres presentan mayor oportunidad de tener exceso de peso (OR: 2,16 IC: 95% 1,22-3,81), en comparación con las docentes mujeres. A su vez, aquellos docentes que comen entre las tres comidas principales, la oportunidad de presentar alto riesgo de enfermedad cardiovascular es 69% menor (OR:0,31 IC:95% 0,15-0,65). Conclusiones: los docentes universitarios de género masculino tienen mayor prevalencia de obesidad y sobrepeso, alto riesgo de adquirir una enfermedad cardiovascular y mayor riesgo cardiovascular en comparación con las mujeres, siendo de causa multifactorial.
Comparison of side effects of the dose-1 of AstraZeneca and Sinopharm vaccines in patients with multiple sclerosis in Kermanshah, Iran (2021)
Authors: Razazian Nazanin , Sahraian Mohammad Ali , Rezaei Mansour , Eskandarieh Sharareh , Khamoushian Kianoosh , Mousavi Seyede Elham , Fakhri Negin
Published: May 2023

Background: Coronavirus 2019 (COVID-19) vaccination is recommended for people with multiple sclerosis (MS). This study evaluated the side effects of Sinopharm and AstraZeneca vaccines in MS patients.
Methods: In this cross-sectional study among MS patients in Kermanshah province, Iran, who received Sinopharm or AstraZeneca vaccine, sampling was performed through convenience sampling according to the nationwide MS registry of Iran (NMSRI). Demographic and clinical information of the participants and data on the side effects of vaccines were collected by telephone after the first dose. The data were analyzed in SPSS software.
Results: 264 vaccinated MS patients (217 with Sinopharm and 47 with AstraZeneca) were studied. In the Sinopharm and AstraZeneca groups, respectively, 58.5% and 73.3% of patients had side effects that were not significantly different between the 2 groups (P = 0.064). In the AstraZeneca group, the severity of side effects and prevalence of taking painkillers were significantly higher (P < 0.050) and the interval between vaccination and side effects onset was significantly shorter (P = 0.013).
The most commonly experienced side effects in the Sinopharm group were fatigue (29.0%), myalgia (24.9%), fever (24.0%), and headache (21.7%), and in the AstraZeneca group were fever (59.6%), chills (51.1%), myalgia (40.4%), and fatigue (34.0%). Logistic regression by controlling for confounding variables showed that considering some factors as confounding factors did not show a significant difference between the 2 vaccines in the experience of side effects (P = 0.104).
Conclusion: The AstraZeneca vaccine caused more severe side effects in MS patients than the Sinopharm vaccine. Most of the side effects were moderate in severity and transient.
Association of Serum 25-Hydroxyvitamin D and Chronic Periodontitis in Postmenopausal Women after Non-Surgical Periodontal Therapy
Authors: Shirmohammadi Adileh , Mohammadi Sanaz , Faramarzi Masoumeh , Babaloo Amir Reza , Sadighi Mehrnoosh , Dizaj Solmaz Maleki
Published: May 2023

Objectives: Vitamin D deficiency appears to have a major effect on periodontal tissue health. The present study aimed to assess the association of the serum level of 25-hydroxyvitamin D and chronic periodontitis in postmenopausal women.
Materials and Methods: This research was done on 30 postmenopausal women with chronic periodontitis who all had at least 20 natural teeth. Intravenous blood samples were taken from the study population at baseline and after completion of non-surgical periodontal treatment. This was followed by assessment of serum levels of 25-hydroxyvitamin D. Next, clinical parameters of all teeth except for third molars were measured, which included pocket depth (PD), gingival index (GI), and plaque index (PI). Data were analyzed by paired t-test and its non-parametric equivalent, the Wilcoxon test. P<0.05 was considered significant.
Results: The mean PD, PI and GI before and after the intervention were significantly different (P<0.05). There was, however, no significant difference between the mean vitamin D concentrations before and after treatment (P>0.05).
Conclusion: According to the results obtained in the present study, there is no association between serum vitamin D concentrations and chronic periodontitis in postmenopausal women.
Aggressive Behavior in a Critically Ill COVID-19 Patient: Possible Role of Medication Discrepancies
Authors: Javidmehr Negar , Reisi-Vanani Vahid , Borran Mina
Published: May 2023

Coronavirus disease 2019 (COVID-19) has different clinical manifestations that besides its iatrogenic intervention could affect brain cognitive function. Medication omission has serious effects on a patient’s clinical course changing the disease’s mortality and morbidity; herein possible role of the iatrogenic intervention that increased the risk of psychological disturbance including medication omission was reported.
A 40-years-old man with a history of gout treated with allopurinol was admitted due to productive cough and hemoptysis. His physical exam and lung spiral chest CT scan revealed moderate to severe lung infiltrations in favor of COVID-19 which was confirmed with COVID-19 RT-PCR. Due to his clinical course tocilizumab, methylprednisolone pulse, and other conservative therapies were started while allopurinol was omitted. During his hospitalization anxiety and irritability appeared and progressed gradually making him refuse to get oxygen supplementation. Through immediate intervention and controlling his behavioral symptoms with psychotherapy, selective serotonin reuptake inhibitors, benzodiazepines, and initiation of allopurinol, the patient’s psychological disturbance were relieved. In the end, he died due to acute respiratory distress syndrome.
COVID-19 and its iatrogenic interventions could trigger a psychiatric disturbance in patients with a variety of pathways. Corticosteroid therapy, non-hypnotic antihistamines, quarantine stress conditions, hypoxia, and medication omission are underlying factors for it. Reporting this medication omission would help physicians become familiar with this pharmacological phenomenon, its prevention, and the way to respond to it. On the other hand, researchers can study the etiology of this phenomenon to understand the mood-stabilizing role of allopurinol in additional studies.
EXPERIENCES AND STRATEGIES OF EDUCATION AND CONSERVATION WITHIN GEOPARKS: A BIBLIOMETRIC REVIEW
Authors: QUİROZ-FABRA Jefferson , VALENCİA-ARİAS Alejandro , LONDOÑO Wilmer , GARCİA-PİNEDA Vanessa , RODRÍGUEZ-CORREA Paula , GARCÍA ARANGO David
Published: May 2023

UNESCO Global Geoparks are characterized by their contribution to the conservation of natural, geological, and cultural resources of the regions where they are located. Geoparks also represent an important figure within the sustainable development of the regions, so strategies around economic growth, conservation, and promotion of education are a fundamental part of their raison d'être. This study aims to identify the main trends in educational and conservation processes in geoparks worldwide. The methodological approach is based on the review of 114 articles from a search equation in the Scopus database, analyzing the results through a series of quantity, quality, and structure indicators. The search period is between 2005 and 2023, so there are recent advances in implementing educational aspects in geoparks. Other results point to the participation of several Asian and European countries as the most predominant, as well as a trend in the implementation of educational processes focused on earth sciences, environmental sciences, and social sciences. Sustainable development and conservation education programs are major players in the findings of this study. In this way, geoparks work as centers for developing conservation dynamics, developing economic and social aspects driven by educational initiatives, and disseminating knowledge to the communities and visitors. The geoheritage tourism sector integrates educational practices into developing experiences to raise awareness among the community and visitors.
La Independencia del Perú a través de las memorias de los ministros del segundo liberalismo
Authors: Amadori Arrigo
Published: May 2023

La restauración de la Constitución de 1812 supuso para el poder central de la Monarquía el establecimiento del entramado institucional que, una década atrás, había sido ensayado por el primer liberalismo. En consecuencia, no solo se produjo el regreso a la plantilla ministerial que funcionaba en mayo de 1814, incluyendo en ella al Ministerio de Ultramar, sino que además se reunieron las Cortes que se transformaron en el articulador político de la construcción de la nación española. Asimismo, durante los primeros tiempos del Trienio Liberal, al menos para el mundo colonial, se recuperó buena parte de la legislación de Cádiz, estableciéndose una línea de continuidad manifiesta entre ambos períodos constitucionales.2 A partir de esta nueva situación política el gobierno central se dispuso a abordar la cuestión americana que, a raíz de la extensión de la insurgencia, presentaba un carácter sumamente complejo y unas perspectivas desalentadoras, aunque el optimismo de los primeros momentos provocó que se contemplase el futuro con esperanza y se asumieran algunas certezas. En esta línea, en el seno de las Cortes españolas se recuperó el pulso de los debates sobre América, aunque ocupando un lugar relegado respecto de otras problemáticas peninsulares (Costeloe, 1989, p. 117).
La cuadratura del círculo y las rendijas del encierro : política de reducción de indios en los Andes en tiempos del Virrey Toledo
Authors: Glave Testino Luis Miguel
Published: May 2023

Nunca mejor dicho, los colonizadores españoles pretendieron «poner puertas al campo» en la política que emplearon para dominar y colonizar a los naturales. El ideal de reducir y concentrar la población rural para poder doctrinarla y administrar su fuerza de trabajo y sus recursos, chocaba con una realidad compleja que se resistía a someterse a esos designios. Dos frenos se encontraron para llevar adelante lo que era un imposible: el desagrado y resistencia que los colonizados manifestaron frente a esos intentos que iban en contra de sus propios ideales de asentamiento poblacional y los factores disruptivos que la propia colonización introducía entre ellos. En los discursos de la colonialidad, siempre se enfatizó en la resistencia de los colonizados, que era tildada como una maña y una perversión. Pero no solo era ese el freno a la reducción del reino. Las nuevas formas de organización de la producción, la circulación y el consumo, implicaron otra cortapisa para congregar y cerrar a las poblaciones de manera ordenada y manejable centralizadamente.
Aprender el "Derecho" y los desencuentros con la realidad
Authors: Pariona Tarqui Leoncia Dania
Published: May 2023

Las reflexiones en torno a mi vida estudiantil en la Facultad de Derecho en la Universidad Nacional San Cristóbal de Huamanga (UNSCH) son las que me motivan a escribir este artículo, así como mi participación en el Proyecto Hatun Ñan y mis primeras experiencias como egresada en los Talleres de Investigación sobre Justicia y Bienestar. Lo hago sin ánimos de caer en el dramatismo ni en la denuncia. La facultad de derecho, así como otras facultades y escuelas de la UNSCH, son espacios de encuentro de identidades culturales, que algunos o, mejor dicho, la mayoría de estudiantes no reconocemos porque no vemos el detrás de la vida de cada estudiante y porque no existe un espacio reflexivo que nos motive a mirarnos. Pero ese espacio está allí, en nuestra lengua, en nuestra actitud, en nuestra manera de pensar y hasta de vestir, que a veces deseamos ocultar. En este espacio académico fue donde empecé a cuestionar silenciosamente cómo aprendemos el derecho. Ello me motivó a preguntarme ¿cómo la manera de aprender el derecho, en cuanto a contenido y metodología, genera cambios de mentalidad conforme se va avanzado en la carrera? y ¿cómo esta forma de aprender el derecho incide posteriormente en nuestro ejercicio profesional, en el que identificamos muchos desencuentros con nuestra identidad cultural y con las personas que buscan justicia?