bluuebunny/crossref_metadata_2025 huggingface dataset:
Cardiac remodeling and outcome after endovascular and minimally invasive closure of atrial septal defect in children
Authors: Shushpannikov P. A. , Halivopulo I. K. , Shabaev I. F. , Sizova I. N. , Omelchenko A. Yu. , Tarasov R. S.
Published: June 2022

Highlights. The article analyzes the features of cardiac remodeling and the outcomes of endovascular and minimally invasive closure of atrial septal defects in children.

Aim. To compare the features of cardiac remodeling (CR) and the outcomes of endovascular and minimally invasive closure of atrial septal defects (ASD) in children.

Methods. The study included 60 children with secundum ASD who underwent minimally invasive (MIC) or endovascular closure (EC) of ASD from the beginning of 2017 to the beginning of 2020. Patients were divided into two groups. The first group (n = 30) consisted of patients undergoing MIC, median age 5 years [2;12], and the second group (n = 30) consisted of patients undergoing EC, median age 5.5 years [1.7;13], p>0.05. The groups were comparable in gender, height, and body weight (p>0.05). The groups differed in the diameter of ASD. ASD defect size was 14 mm [7;30] in the MIC group, and 11.5 mm [7;22] in the EC group. The following indicators were assessed during hospital stay: the outcome of the intervention, residual shunt, hospital-acquired complications, and indicators that characterize CR before the procedure and 3-4 months after surgery.

Results. The analysis revealed that all children successfully underwent minimally invasive and endovascular closure of ASD (confirmed absence of residual shunt). Hospital-acquired and long-term complications were not detected. Data are presented as a median and percentile. In the MIC group all patients required blood transfusion, intraoperative blood loss was 445 mL [300;1290], while in the EC group the blood loss did not exceed 5 mL [5;15], p = 0.001. EC was much more advantageous in terms of length of hospital stay (LoS) compared to MIC; in the MIC group LoS was 8 [6;14] days, and in the EC group LoS was 3 [3;4] days, p = 0.001. LoS in the Department of Anesthesiology and Intensive Care after MIC was 24 [3;96] hours, while patients in the EC group did not need to be transferred to this Department, p = 0.001. In both groups, significant changes were observed during 3–4-month follow-up in the form of a decrease in the volumetric and dimensional parameters of the right chambers and simultaneous increase in the same parameters of the left chambers.

Conclusion. Minimally invasive and endovascular surgeries are effective and safe treatment modalities for ASD in children (median age of 5–5.5 years), which positively affect CR according to 3–4-month follow-up. At the same time, the advantages of EC regarding the intraoperative blood loss / blood transfusion, the need for mechanical ventilation, cardiopulmonary bypass, and LoS in the ICU and hospital are highlighted.
Booster vaccination against SARS-CoV-2: current challenges and solutions
Authors: Drapkina O. M. , Berns S. A. , Gorshkov A. Yu. , Ivanova A. A. , Ryzhakova L. N. , Bashnyak V. S.
Published: June 2022

Highlights. Nowadays the only way to prevent a new coronavirus infection is vaccination. Overcoming such problems as a gradual decrease in the effectiveness of post-vaccination immunity and the emergence of new strains of SARS-CoV-2 is possible due to booster vaccination. The review highlights the current data on the effectiveness and immunogenicity of various booster vaccination regimens and prospects for studying this issue in the Russian Federation.

Abstract. The COVID-19 pandemic is going on, which makes it crucial to prevent the spread of coronavirus disease. Vaccination is the only way of specific prevention of COVID-19. The SARS-CoV-2 virus is continuously evolving and new variants appear. Moreover, the effectiveness of protective immunity after vaccination tends to decrease over several months. Booster vaccination may be the solution to these problems. The booster is an extra vaccination that helps to reactivate the immunity against COVID-19. Booster doses can be homologous (the same as the primary vaccine) and heterologous (different from the primary vaccine). It is of current interest to study heterologous vaccination as the injection of different vaccines may result in a more intense immune response. Furthermore, the same vaccine may not be available at the time of booster vaccination. This review is aimed at summarizing the key research findings in the field of booster vaccination against COVID-19.
Association of the quality of life parameters with the indicators of chronic heart failure severity in patients with rheumatoid arthritis
Authors: Ankudinov Andrey S. , Kalyagin Alexey N.
Published: June 2022

Background: The quality of life of patients is one of determining factors in assessing the effectiveness of treatment and prognosis. A search for possible associations of the quality of life parameters with basic clinical indicators provides a possibility of a more detailed and comprehensive assessment of the patients condition, correction of therapy and an improvement in the prognosis. Aim: To carry out a comparative analysis of the quality of life parameters in patients with chronic heart failure (CHF) with preserved and moderately reduced left ventricular ejection fraction against the background of rheumatoid arthritis (RA) and without RA, as well as to identify possible associations of the quality of life indicators with the parameters of the CHF course. Methods: 134 CHF patients with an RA diagnosis were examined, as well as 122 CHF patients without RA. The functional class of CHF in patients participated in the study was I -II by NYHA. The diagnosis of RA was made on the basis of radiological and serological studies. The radiological stage of RA in patients included in the study was I -III, according to Steinbrocker. Methotrexate was the basic anti-inflammatory drug for the RA treatment. A comparative analysis of the CHF symptoms, morphofunctional parameters and their possible association with the quality of life indicators in patients with and without RA was performed. The processing was carried out using the Statistica 10.0 program. Results: In the group of patients with CHF and RA, in addition to the statistically significant differences in the standard clinical laboratory parameters, statistically significant differences were also revealed in the severity of pain syndrome, deterioration of role, physical and emotional functioning as compared to the CHF patients without RA. Besides, in the CHF/RA group, statistically significant associations were revealed between the severity of pain syndrome and the level of the left ventricular ejection fraction and left ventricular mass index. Conclusion: The severity of pain syndrome caused by RA in patients with CHF can negatively affect some morphological and functional parameters of the myocardium, which must be taken into account when managing this group of patients.
Phytoremediation of chromium, iron and nickel by Indian Rice Plant (Oryza sativa L.): An opportunity for management of multi-metal contaminated tannery wastewaterPhytoremediation of chromium, iron and nickel by Indian Rice Plant (Oryza sativa L.): An opportunity for management of multi-metal contaminated tannery wastewater
Authors: Katiyar Arti , Bhaskar Monika , Singh Amit , Sharma Divakar , Abhishek Amar , Garg Vishal
Published: June 2022

India is the largest producer of leather and leather products. Tannery industries use a large number of synthetic chemicals for the processing of leather and generate a huge amount of wastewater containing a large amount of potentially toxic heavy metals (PTHMs) making them problematic for next-door soil and water system. Currently, phytoremediation is an inexpensive green technology used to move, eradicate, and stabilized heavy metal contamination from contaminated sludge, soil, and wastewater. In this study, the accumulation and distribution of PTHMs found in tannery wastewater and their physio-biochemical effects on Oryza sativa L. have been studied by ICP-MS, GC-MS, and biochemical analysis. The plant was grown in the soil spiked with a mixture of metals (Cr, Fe and Ni) and their five-level of treatment T1 (25mg/kg); T2 (50mg/kg); T3 (100mg/kg); T4 (200mg/kg) and T5 (400mg/kg). During the experiments, various morphological attributes, oxidative stress, enzymatic activities, chlorophyll, and protein content at the different stage was measured. Further, metal accumulation pattern in different parts of plants was also measured. Results of the study revealed that plant root, shoot length, chlorophyll content, and enzymatic activities were significantly reduced after the treatment with 200 mg/kg PTHMs; whereas oxidative stress was increase compared to control levels.  Further, treatment of PTHMs suggested that the rice plant (Oryza sativa L.) is well adapted to tolerate and accumulate a high level of heavy metals (up to 200mg/kg) in the root and shoot of the treated plants. If it is treated above this, then seeds were also affected and not safe for human consumption.
A pilot study of Resilience Programme through Group Dynamics on Academic Problems among the Matthayom Suksa 1 Students of Chiang Mai University Demonstration School
Authors: Kumkun Chanakarn , Chupradit Supat , Sirisatayawong Pornpen
Published: June 2022

The objective of this study was to develop a Resilience Programme through Group Dynamics on Academic Problems among Matthayom Suksa 1 Students at Chiang Mai University Demonstration School. For this, four junior high school students were selected as respondents. The effect of the resilience program was evaluated through a general questionnaire, the Canadian Occupational Performance Measures (COPM), and Resilience Inventory. Further, the resilience program was developed by using cognitive behavioral therapy combined with acceptance and commitment therapy, group dynamics, and resilience according to the concept of Grotberg. The total period of the program was 11 weeks, with 1 session per week lasting for 60 minutes. Results of the study revealed that all the selected respondents had higher academic performance and most of them (75%) had higher academic satisfaction and resilience score. After participating in this program, the samples had a higher average resilience score (114.5) as compared to those before participating in the program (107.5). The results of this study can be concluded that the newly developed resilience program can improve the resilience component in almost all the students. Hence, it can be practiced in junior high school students to manage their academic problems. This program can also be a prototype for developing future resilience programs.
Vaccine hesitancy toward the COVID-19 vaccine among the Malaysian population
Authors: Azizan A. H. , Subramaniam G. , Sivasamugham L. A. , Gopinathan S. , Raman M. , Wong L.S.
Published: June 2022

COVID-19 is a potentially fatal infectious disease that requires effective vaccines to keep the outbreak under control. Despite the ongoing efforts for an effective vaccine, public hesitancy towards vaccines is now one of the main concerns to the global health in containing this global pandemic. Thus, this preliminary study was carried out to assess the degree of COVID-19 vaccine hesitancy among the general public in Malaysia and to identify the underlying reasons for their hesitancy by using 5C psychological antecedents of vaccination. This study was conducted by carrying out a cross-sectional online survey for approximately two months between January to February 2021, involving 385 participants. The survey contained questions based on the 5C model proffered by WHO. The data from the survey were analyzed using Smart PLS 3 for statistical analysis, with the partial least squares structural equation modeling (PLS-SEM). According to the findings, only 62.5 percent out of the 385 participants had planned to get the COVID-19 vaccine, while the remaining 37.5 percent did not. The results also showed that confidence, calculation, collective responsibility, and constraints had a significant influence on vaccine hesitancy but not complacency. There is a degree of vaccine hesitancy towards the COVID-19 vaccines among the Malaysian population, although the data that we have obtained cannot be used to generalize for the entire Malaysian population due to the small sample size. Thus, for the vaccination campaign to be more effective, it should focus more on addressing the issue relating to confidence, calculation, collective responsibility, and constraints and less on complacency.
Morphotaxometry and Ultratopography of Lytocestus haryanii n.sp. (Caryophyllidea: Lytocestidae) from the intestine of freshwater catfish Clarias batrachus Linnaeus 1758 (Siluriformes: Clariidae) of river Yamuna, Yamuna Nagar, Haryana, India
Authors: Babita  , Upadhyay Dr Sushil Kumar , Tuli Hardeep Singh , Dhama Kuldeep , Chandran Deepak , Mohapatra Ranjan Kumar , Singh Manoj
Published: June 2022

The present investigation deals with the first report of newer species of caryophyllid cestodes, Lytocestus haryanii n.sp. (Caryophyllidea: Lytocestidae) in the freshwater catfish, Clarias batrachus Linnaeus 1758 (Siluriformes: Clariidae) of river Yamuna from Yamuna Nagar, Haryana, India from July 2018 to June 2020. These helminthes are the most common cestodes (endoparasites) among the fishes of fresh water, brackish water, and marine habitat worldwide.  The recovered newer worms were processed through the standardized protocol for the microscopic observations and morphometry, ultratopographic study through scanning electron microscopy, and anatomical analysis by histology using microtomy techniques followed by the double staining. The findings of the present worms were substantiated and compared with the earlier reported species of the same genera from different hosts shared the common group using advanced numerical taxonomy for the taxometric validation. The present proposed newer worms shared all the common characteristics which helped in the generic diagnosis and are closely related to the species collected from the same host species inhabiting different freshwater bodies. The worms comprised several striking contrasts in the combination of distinguishing characters of taxonomic significance in special reference to shape, size, orientation, distribution, and the dimension of the body (single proglottid), scolex, neck, testes, ovary, cirrus pouch, vitellaria, eggs, and excretory pore. Based on the striking morphological, taxometric, ultratopgraphic, and histological differences summarized here can, therefore, be used to propose the worm as a new species.
Characterization of Biochar Empty Fruit Bunches OPEFB at Various Temperatures and Burning Time
Authors: Marhani  , Sahur Asmiaty , Laban Sartika , Musa Yunus
Published: June 2022

Oil palm waste (OPW), comprising mainly of empty fruit bunch, mesocarp fiber, frond, trunk, and palm kernel shell generated from the palm oil industry, was collected, characterized, and then pyrolyzed to evaluate their potential to be converted into biochar.  Oil Palm Empty Fruit Bunches (OPEFB) are a source of organic material with abundant nutrients and are highly potentially useful as biochar. This article provides experimental data for the production of biochar at a temperature range of 100 to 300 °C at time of 4 to 8 hours. The chemical components examined are pH, CEC, C-Organic, N-total, C/N, K dd, P, Ca, Mg, and Na, using Fourier Transform Infrared Spectroscopy (FTIR). The results showed that organic C, nitrogen, and pH were highest at 200–300 °C and had a burning time of 8 hours. Furthermore, the highest concentrations of P, Ca, and Mg were recorded at 200–300°C after 5 hours, Kdd at 100–200 °C after 5 hours, and Na and CEC at 200–300 °C after 4 hours. The transmittance intensity produced by the spectrum of hydroxyl (O-H) vibrations, carbonyl stretching (C=O), alkanes    (-CH), and aromatics (C=C) decreased with increasing time, while stretching alcohol (C-O) vibrations increased with time. Our results demonstrate that OPEB is a biowaste that shows exceptional promise to be transformed into high-grade biochar rather than simply disposed of by landfilling or burning.
Cold spray additive manufacturing of copper-based materials: Review and future directions
Authors: Menon Vineeth , Aranas Jr. Clodualdo , Saha Gobinda
Published: June 2022

The cold gas dynamic spray process is a manufacturing process strategically designed for coatings. The conditions for the deposition of materials to form coatings have evolved over several decades. Copper and copper-based cold spray coatings are an interesting field for investigation, as it has substantial commercial demand and acceptance. Several important works have already been performed in this regard that shows the immense popularity of its applications in power industries. Cold gas dynamic spray, being an economic process, can produce coatings with superior quality and low oxidation. In this paper, a particular focus has been given to copper-based cold spray coatings along with their deposition parameters. The various mechanical, electrical, corrosion, and tribological properties of these copper-based cold spray coatings are commendable and economically lucrative. A good amount of experimental data has also been included in this review article to provide comprehensive information and future scope of research about copper-based cold spray coatings.
Corporate Social Responsibility (CSR) Disclosure on Politically Connected-Family Firms
Authors: Sucahyati Diarany , Harymawan Iman , Nasih Mohammad
Published: June 2022

Research aims: This study examines the relationship between political connections and family ownership toward CSR activities disclosure.Design/Methodology/Approach: This study employed 624 Indonesian public companies on the Global Reporting Initiative (GRI) list for 2010-2018. The researchers used OLS (Ordinary Least Squares) regression by considering the fixed effect diversity of industry, year, and type of GRI to examine the relationship between political connections and family ownership on CSR disclosure.Research Findings: This study discovered that companies with political connections disclosed more CSR activities because they desired to bind themselves with the government, instruments of legacy, and social motivation. However, family firms were not found to have a significant relationship with CSR disclosure. In addition, the strong family ownership in the firm impacted the reduced strength of political connections, thereby reducing the company's CSR activities disclosure. Theoretical contribution/Originality: This study is interesting because the researchers combined the issue of the politically connected board and family firms, which are frequently found in the context of Indonesian companies. The researchers expect this study to enhance corporate board characteristics and CSR disclosure literature. Practically, the researchers expect this study could provide useful information for investors to make investment decisions. Furthermore, this study provides insight for regulators, who need a view of how political connections and family companies exist in responding to the regulations they set. Therefore, the existing regulations can be improved. Yet, this study was limited to the proxy of political connection based on local regulation of politically exposed person (PEP).
Comparison of dinoprostone slow-release vaginal insert with intracervical Foley catheter in cervical ripening for induction of labour: a prospective observational study
Authors: S. Vaanathi , John Lopamudra B.
Published: June 2022

Background: Cervical ripening prior to induction of labour is crucial as unfavorable cervix with poor Bishop’s score can lead to caesarean section. Two most widely used methods are vaginal dinoprostone and intracervical Foley catheter. Studies conducted worldwide to determine the efficacy and safety of these methods provided no consensus regarding superiority. Thereby, the present study aims to compare the efficacy of these two methods for successful cervical ripening during induction of labour.Methods: In this prospective observational study, all antenatal women admitted for induction of labour satisfying the inclusion criteria were enrolled. Women in group A were induced with dinoprostone slow-release vaginal insert and those in group B with intracervical Foley catheter. Sample size was 72 in each group. Both the groups were followed till delivery and assessed for improvement in Bishop’s score, induction to active phase duration, induction to delivery time, use of other agents, mode of delivery, incidence of hyperstimulation and neonatal outcomes.Results: Induction to active phase duration and to delivery time was statistically shorter in dinoprostone slow-release vaginal insert group than intracervical Foley group. Improvement in Bishop’s score, mode of delivery and indication for LSCS were not statistically significant. Uterine hyperstimulation was significantly higher in Dinoprostone insert group. Neonatal outcomes were similar.Conclusions: Dinoprostone slow-release vaginal insert resulted in better Bishop’s score during re assessment, reduced need for second agent, shorter induction to active phase and to delivery time when compared with intracervical Foley catheter and so can be used effectively for successful cervical ripening.
A study of correlation of endometrial morphology and subendometrial vascularity with pregnancy rate in fresh and frozen embryo transfer cycles
Authors: Parasnis Mugdha A. , Bandaru Udaya K.
Published: June 2022

Background: Aim of the study was to evaluate the correlation of endometrial morphology and sub endometrial vascularity with pregnancy rate in fresh and frozen embryo transfer cycles.Methods: Prospective, non-randomized observational study done on 76 women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment at a tertiary health care center. Woman with tubal factor, male factor and unexplained infertility were included in the study. Parameters like endometrial thickness, endometrial pattern, endometrial blood flow were correlated to clinical outcomes such as implantation and clinical pregnancy rates. Independent two-tailed t-test and chi-square test was used as a part of statistical analysis.Results: There is no significant difference in distribution of mean age, mean duration of infertility, cause of infertility, mean basal follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), progesterone (P4), anti-Mullerian hormone (AMH), total gonadotropin dose, median E2 (on day of trigger), median P4 (on day of trigger), number of embryos transferred and endometrial thickness between group of cases with positive and negative pregnancy in our study group. Whereas body mass index (BMI), blastocyst quality of embryo transferred, triple-line pattern of endometrium and endometrial blood flow reaching zone 4 were found to be significant in the study group.Conclusions: A combination of endometrial thickness and Doppler analysis of endometrial blood flow was a simple and effective tool to improve pregnancy rates in hormone replacement treatment-frozen embryo transfer (HRT-FET) cycles and should be incorporated into routine clinical practice. In addition, this can help us reduce the number of embryos to be transferred and hence, the multiple pregnancies and the associated complications.
Assessment of menopausal symptoms using modified menopause rating scale among urban women doctors of India
Authors: Patankar Ujjwala S. , Sonak Mangala M. , Patankar Sameer U. , Patil Rashmi R. , Upadhye Aditi J. , Upadhye Jayshree J.
Published: June 2022

Background: The study was conducted to assess the commonly reported menopausal symptoms among urban women doctors using modified menopause rating scale (MRS).Methods: The study was carried out in the society by google link. Convenient sample of 100 women doctors were included in the study. Menopausal symptoms were assessed using modified MRS.Results: In present study, 3 (3%) female doctors had premature menopause, 5 had menopause at 40-44 years, 15 (15%) had menopause at 45-49 years, 77 (77%) had menopause while no patient had menopause after 55 years. Hot flushes were seen in 70 (79%) women, heart discomfort/ palpitation was seen in 2 (2%) women, muscle and joint problems were seen in 30 (30%) women, sleeping problems were seen in 20 (20%) women. Depressive mood was seen in 2 (2%) women, irritability was seen in 12 (12%) women, an anxiety was seen in 22 (22%) women while physical and mental exhaustion was seen in 34 (34%%) women. Sexual problems were seen in 32 (32%) women, bladder problems were seen in 8 (8%) women dryness of the vagina was seen in 35 (35%) women (Table 6).Conclusions: Hot flushes and joint problems were the most common followed by urogenital symptom, sleep disturbance, and anxiety in the study. Menopausal symptoms were less prevalent. Busy schedule, self-confidence due to independent nature and constructive work might be the reason.
The prevalence of insulin resistance in polycystic ovarian syndrome cases at a tertiary care hospital: a cross sectional study
Authors: Borse Rama D. , Kurkal Nidhi S. , Abhade Aditi H.
Published: June 2022

Background: Insulin resistance (IR) is defined clinically as the inability of a known quantity of exogenous or endogenous insulin to increase glucose uptake and utilization in an individual as much as it does in a normal population PCOS is a disease of heterogeneous disturbance of reproductive, endocrine and metabolic functions. The objective of the study was to study the prevalence of insulin resistance in polycystic ovarian syndrome cases.Methods: The present cross sectional study was carried out at Obstetrics and Gynecology department, MGM medical college, Kalamboli, Navi Mumbai for a period of 2 years from 2011 to 2013 on total of 50 women aged between 16-39 years, coming to OPD with complaints of menstrual irregularities, infertility or hirsutism. After initial assessment, pelvic ultrasonography was done in these women to confirm the diagnosis of polycystic ovaries.Results: Majority 26 (52%) cases were in age group of 16-25 years and, majority 19 (38%) cases were in overweight (25-29.99) group. There were 21 (42%) women with insulin resistance When chi square test was applied to assess the association between BMI and insulin resistance, it was found to be statistically significant. (p=0.01).Conclusions: The prevalence of abnormal glucose tolerance, dyslipidemia, insulin resistance and metabolic syndrome was observed to be high in PCOS. We conclude that physician should consider that early recognition to reduce the incidence and severity of associated potential sequelae.
Comparison of neonatal birthweights and fetomaternal outcomes in gestational diabetes-on diet, metformin and insulin
Authors: Dixit Siddhi Shree , S. Sudha , C. R. Greeshma
Published: June 2022

Background: Review suggested that neonatal birthweight in insulin group was higher than in metformin and diet and metformin had overall better fetomaternal outcomes. We wanted to understand the trend in the patients visiting our hospital.Methods: This is an observational comparative study conducted in Department of Obstetrics and Gynaecology, AIMS Kochi from 2019-2021. All antenatal patients were screened and total of 153 patients meeting inclusion and exclusion criteria were studied. The data was collected and analysed using SPSS 20 software.Results: The neonatal birthweight the three groups were comparable, with no significant difference (3.05±0.42 kgs in diet; 2.92±0.37 kgs in metformin; 3.11±0.41 kgs in insulin; p=0.092) and maternal pre-pregnancy weight was associated with birthweight. Insulin group had higher age (31.17±5.54 years versus 27.59±4.62 years in OHA and 29.43±4.56 years in diet; p<0.001). Insulin group delivered at an earlier gestation (37 weeks versus 38 weeks; p<0.001) and most common mode of delivery was cesearean section (74.6% in insulin; 54.2% in diet and 49.8% in OHA). NICU admission (45.8% versus 10.8% in diet and 15.4% in OHA; p<0.001) and need for phototherapy (1.5% in metformin versus 5.4% in diet and 11.8% in insulin; p=0.067) was lesser in metformin group.Conclusions: Strict glycemic control is important in preventing macrosomia Metformin overall has good fetomaternal outcomes compared to diet or insulin.
The interest of uterine artery ligation in gynecological surgery: the experience of Obstetrics and Gynecology Department at Mohammed VI University Hospital in Oujda, Morocco
Authors: Meziyane Jihane , El Ghali El Hassan , Graiti Ghizlane , Taheri Hafsa , Saadi Hanane , Mimouni Ahmed
Published: June 2022

Ligation of the uterine arteries is the placement of a clip or a ligature on the uterine artery allowing the devascularization of the irrigated area of the uterus. Indeed, in order to limit uterine bleeding during a myomectomy or a difficult hysterectomy, primary ligation of the uterine arteries is proved helpful. Our work aimed to discuss the indications for artery ligation uterine, describe its different techniques and assess its effectiveness and benefit. Our work was a retrospective analytical descriptive and mono-centered study, involving 21 patients who underwent vascular ligation of the uterine artery, as first stage of surgery, regardless of the approach, as part of a myomectomy/polymyomectomy or hysterectomy, in the Gynecology And Obstetrics Department at the Mohammed VI University Hospital of Oujda, over a period of thirty-four months, going from January 2019 to October 2021. The average age of the patients in our study was 39 years old. 66.7% of patients benefited from a myomectomy/polymyomectomy while 28.5% underwent a hysterectomy. The first technic was laparoscopy in 52.3% of cases and the second laparotomy in 47.7% of cases. The ligation of the uterine arteries was performed bilaterally, permanently by vascular clips in all patients. Blood loss was estimated to be 121 ml on average with extremes of 45 and 350ml, the hemoglobin level decreased by an average of 0.7 g/dl and none of the patients in our study required an intraoperative or postoperative transfusion. Occlusion of the uterine arteries seems to have a remarkable effect in reducing blood loss during gynecological surgery and does not increase the risk of intra or postoperative complications. However, more studies are required to assess its impact on subsequent fertility.
Megarectum in pregnancy causing coital penetration failure
Authors: A. Basir Rabiatul Adawiah , Ab Rahim Mohd Fadliyazid , Johari Rozliana , Ramli Roziana
Published: June 2022

Megarectum rarely occur in adults. Rectal innervation abnormality or rectal muscle dysfunction could be the underlying pathophysiology, but there are cases where no specific cause is found. Only a handful of cases of megarectum in pregnancy were reported in the literature. Raised progesterone and reduced motilin level during pregnancy may affect bowel motility and predispose pregnant patients to this unusual condition. Clinical presentation ranges from bowel symptoms e.g. chronic constipation, nausea, vomiting and abdominal pain to dysfunctional labour including labour dystocia and obstructed labour. We hereby present a 23 year old lady in early pregnancy who presented with coital penetration failure due to megarectum. We wish to discuss the impact, outcome and management of this rare condition in pregnancy.
Atypical presentation of posterior reversible encephalopathy syndrome: a case report
Authors: Nagasuri Sri Sushma , Konin Savita , Devarmani Meenakshi
Published: June 2022

Posterior reversible encephalopathy syndrome (PRES) is a reversible syndrome characterized by seizures, headache, altered mentation, and loss of vision associated with white matter changes on imaging. A 25-year-old primigravida presented at 31 weeks gestation with atypical PRES characterized by generalized seizures and altered mental status. Magnetic resonance brain imaging showed high-intensity lesions in bilateral corona radiata, capsulo-ganglionic region, genu and splenium of corpus callosum, cortical and subcortical white matter of bilateral high fronto-parietal, bilateral cerebral peduncle, pons and medulla. Cases of antepartum atypical PRES are rare. Patients with atypical PRES do not always show typical manifestations. Our case reports highlight the crucial role of a prompt diagnosis, the importance of rapid blood pressure reduction, with a multidisciplinary approach.
Yolk sac tumor, a rare and challenging ovarian malignancy: case report
Authors: Ara Anjum , Kumari Kanika , Rani Sushma , Chawla Indu , Ahuja Arvind , Phulware Ravi H.
Published: June 2022

Yolk sac tumors (YST) are rare and rapidly developing neoplasm presenting in young females. They are second most common germ cell tumor after dysgerminomas. Fertility preservation is an important concern in treatment of patients of YST. We present a case of 22 years nulliparous female with rapidly evolving abdominal mass. The patient underwent fertility preserving surgery with four cycles of post operative bleomycin etoposide and paclitaxel (BEP) chemotherapy and is fairly doing well. BEP chemotherapy has successfully improved the treatment outcomes of YST patients.
Amniotic band syndrome: a diagnostic dilemma
Authors: Mishra Vineet V. , Solanki Smit B. , Aggarwal Rohina , Shah Kunir , Anusha M.
Published: June 2022

Amniotic band can cause a broad spectrum of anomalies ranging from simple band constrictions to major craniofacial and visceral defects. It can cause significant neonatal morbidity. Accurate diagnosis is very important for further management of the pregnancy and in counseling with regard to future pregnancies. Here we reported a case of amniotic band syndrome which was missed for ‘Milroy’s primary congenital lymphedema’ in antenatal sonography but was revealed in fetal autopsy.
Medical embryology in the of light Qur’an and Hadith
Authors: Dar Moahammad Abass , Charak Garima , Bala Suman , Naik Suboor
Published: June 2022

The conceptual description and obvious originality of human medical sciences gleaned from core and authentic religious texts and preaches are frequent expunged from the real face of the medical literature. Valuable comments and commentaries made concerning the chemical and molecular basis of medical embryology as found in the Qur’an and Hadith are discussed in the present review aims. Based on this aptly review, it is obvious that these early sources both had an excellent comprehension regarding medical embryology of the human body. Man’s quest to food for thought and to keen know about his origin has led him to soul searching his ancestral and chemical roots and the best valid sourced data for him has been religious scriptures. Modern embryology is a fairly present-day development which lights to the day with the invention of microscope in the 17th century. However, the concept of the development of human being in the stage wise not recognized until much later. But as per fact and clearcut description the holy Qur’an and Hadith had provided a detailed explanation of the significant events in human development from the stages of basic chemical level crosses the molecular level up to level of organism development or even parturition and post-partum.
Micro-vascular reconstruction of complex post traumatic ankle and foot defects with free anterolateral thigh flap: single centre experience
Authors: Jain Rakesh Kumar , Sinwar Prabhu Dayal , Pumbhadiya Milan , Sharma Rahul
Published: June 2022

Background: Ankle and foot reconstruction is challenging for plastic surgeon due to paucity of local soft tissue and poor blood supply. Anterolateral thigh (ALT) free flap become popular reconstructive option where microsurgical expertise available.Methods: Retrospective study of 26 patients of complex post traumatic ankle and foot defect underwent free anterolateral thigh free flap reconstruction during 2 years duration.Results: ALT free flap provides satisfactory reconstructive option with only 8% flap loss in our study and minimal donor site morbidity. Flap thinning required in 19% patients on long term for adequate shoe fitting.Conclusions: ALT free flap provide like with like tissue replacement for foot and ankle reconstruction with supple skin cover for subsequent surgeries if required.
Clinico-pathological evaluation and co-morbidities in superior mesenteric artery thrombosis
Authors: Shukla Snehil , Singh Urvashi , Patel Badri Prasad , . Vignesh
Published: June 2022

Background: Mesenteric artery thrombosis (MAT) is a condition involving occlusion of the arterial vascular supply of the intestinal system. It is a severe and potentially fatal illness typically of the superior mesenteric artery (SMA), which provides the primary arterial supply to the small intestine and ascending colon. The occlusion may occur due to underlying atherosclerotic disease or embolic occlusion from a distant source, as atrial fibrillation. The condition possesses a high mortality rate and prompt recognition and treatment are of utmost importance.Methods: A retrospective, observational, single hospital base study done during the period from 2015 to 2020 in the department of surgery, Gandhi Medical College, Bhopal. Sample size was taken 50 patients.Results: In our study, out of 50 patients, 34% patients were in the age group between 55-65 years, history of smoking was present in 44%, hypertension in 36%, past history of atrial fibrillation in 10%, signs of peritonitis were present in 62% patients. Out of 50 patients, 42% was operated while 58% were managed conservatively. Amongst operated patients, in 72% partial bowel resection was done while in 28% extensive bowel resection was done, 66% were discharged while 28% patients died, amongst 21 operated patients, 57% were discharged while 43% died.Conclusions: In this study, SMA thrombosis is more common in patients with smoking, cardiac diseases (hypertension, atrial fibrillation, ischemic heart disease, CVA), dyslipidaemia. Early intervention as thrombolysis or bypass surgery is needed to prevent complications like extensive bowel ischemia.
Female geriatric patients with traumatic brain injury have better odds of survival compared to men-a meta-analysis and review of the literature
Authors: Pandya Shreya , Fedoriv Ivan , Le Timothy N. , Liu Jacqueline , Singer Tori , Kennedy Kaitlyn , Singer Kiara , Lee Bryan , Kaykaty Vincent , Butler Kevin , Singh Kailey , Patel Nikhil , DiRoma Frank , Gave Asaf , Gilad Ronit , Younan Duraid
Published: June 2022

Geriatric trauma patients have worse outcomes compared to younger patients. Differences in trauma outcomes based on gender remain unproven. We sought to investigate the association of gender with outcomes among geriatric patients with traumatic brain injury (TBI) by performing a meta-analysis and review of the literature. A systematic review of published articles on outcomes of geriatric patients with TBI using PubMed was conducted. A total of 363 articles were identified, from these, 74 articles met the inclusion criteria of isolated TBI in geriatric patients. Upon review of the articles, only 5 met the specified criteria of the search which described male and female mortality amongst geriatric patients suffering isolated TBI. The data from these papers were combined into a master file and meta-analysis was performed using random-effect model with Rev Man 5.4 software. The total number of patients in these 5 papers was 23,893, of these 11,971 were men and 11,922 were women. The odds ratio for survival in these patients were 1.40, 2.40, 1.20, 1.28 and 1.15 with a combined final OR of 1.28 favoring women with a p value of less than 0.00001 and CI of 1.21-1.36. Female geriatric trauma patients sustaining TBI have better survival than men.
A case of spontaneous gastric perforation in a 3 years old male child
Authors: Dhar Pinak Pani , Dey Abhik
Published: June 2022

A 3 years old boy attended emergency department with history of abdominal distension, fever, vomiting, loose stools for 5 days. The boy was suffering from epilepsy from last 1 year of age and was under treatment. From history and clinical examination, it seemed to be a case of peritonitis. Abdominal ultrasound revealed debrigenous free fluid in peritoneal cavity. Emergency exploratory laparotomy done and pyloric perforation was noted and repaired by modified graham’s patch. The child, post-operatively, suffered from dys-electrolytemia and wound site infection and recovered with treatment.
Comparative study of prevalence of hypothyroidism in cirrhotic patients and normal individuals
Authors: Charpota Harish , Meena Rajesh , Meena O. P. , Kaur Gurdeep , Katara Deepa , Meena Atul
Published: June 2022

Background: Alcoholic cirrhosis has worse prognosis than primary billiary cirrhosis and cirrhosis due to hepatitis. The risk of death due to all cause is increased 12-fold with cirrhosis. Alcoholic liver cirrhosis develops between 10-20% of individuals who drink heavily for a decade or more. Chronic hepatitis B is probably the most common cause of cirrhosis worldwide. The aim and objective of this study was to compare the prevalence of hypothyroidism between cirrhotic patients and normal healthy individuals.Methods: The present study constitutes of 50 patients with cirrhosis of liver who met our inclusion criteria. They were selected from the patients admitted in medical wards and gastroenterology ward of RNT medical college, Udaipur.Results: Majority of patients were of serum albumin level class III about 67%. Increased TSH level as compare to level of serum albumin in cirrhotic patients. When serum albumin level decreases then percent of TSH level increases. Majority of patients were from serum bilirubin class III (71%). Majority were from serum bilirubin class III about 70%.Conclusions: All cirrhotic patients should undergo for evaluation of endocrinological evaluation as these patients are associated with development of hypothyroidism. After diagnosis the treatment of endocrinological disorder especially hypothyroidism may increase survival.
A study on correlation of anemia with left ventricular hypertrophy in chronic kidney disease patients: a cross sectional study from Southern Rajasthan
Authors: Meena O. P. , Meghwal Hemlata , Meena Rajesh , Gurjar Surendra
Published: June 2022

Background: Chronic kidney disease is becoming epidemic of twenty-first century. With increasing burden of diabetes and hypertension, chronic kidney disease is becoming rampant in our country. Adverse outcome of CKD includes kidney failure, complications due to decreased kidney function and cardiovascular disease etc. Increasing morbidity and mortality of coronary artery disease in CKD patients make it necessary to develop further researches in these population. Aim and objectives of current study were to demonstrate the correlation of anemia with left ventricular hypertrophy in a cohort of CKD patients in a tertiary care centre.Methods: This study was done over one year on 100 patients of CKD (stage III to V), aged 15-80 years, who had elevated serum creatinine and reduced glomerular filtration rate, haemoglobin <11 gm/dl with ultrasonographic evidence of renal parenchymal disease grade >2. The patients were assessed based on clinical history and a number of laboratory parameters including blood urea, serum creatinine, calcium, inorganic phosphorus, serum electrolytes, iPTH level, Hb, Hct, glomerular filtration rate and left ventricular mass index.Results: There is a significant relationship between of anemia and left ventricular hypertrophy among chronic kidney disease patients. In our study, it was observed that left ventricle mass (left ventricular mass index) increases with increasing severity of anemia.Conclusions: Anemia is widely prevalent in our CKD patients. Severity of anemia is correlated to left ventricular hypertrophy in these patients. Hence correction of anemia early in these group of patients can halt or prevent cardiovascular morbidity and mortality.
Comparative in vitro antimicrobial study of Panchavalkal and modified Panchavalkal in three different extract solvents: a study protocol
Authors: Naik Kamal Satgonda , Gupta Rajkumar B.
Published: June 2022

Background: Charak, Sharangdhar, Kashyap, BhavaPrakasha described Panchavalkala, is a combination of five astringent barks viz., Vata (Ficus bengaenesis Linn.), Udumbara (Ficus glomerata Roxb.), Ashvattha (Ficus religiosa Linn.), Parisha (Thespesia populanea Soland excorrea) and Plaksha (Ficus slacor Buch-Ham.). In Ayurveda sometimes substitute plants are described to work better for a particular medical condition.  Such type of alternative drug suggested by BhavaMishra and Kaiyadeva Nighantu for classical Panchavalkala is Shirish (Albezzia lebbeck Linn.) in place of Parisha. Such type of altered Panchavalkal is called as modified Panchavalkal. Both Panchavalkals are essentially important in acute, chronic ulcers, wound healing and reproductive health concern women’s diseases like leucorrhea, irregular or heavy bleeding etc. So, these Panchavalkals at three different extract solvents i.e., water extract, alcoholic extract and hydro alcoholic extract in comparison to standard anti-microbial drugs will be studied.Methods: Panchavalkal and modified Panchavalkal in water, alcohol and hydro alcoholic extract will be subjected to a test antimicrobial property by agar well diffusion method. Results will be assessed on the basis of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and the zone of inhibition (ZOI) of plant   extracts against the microorganism that will be measured.Conclusions: Conclusion will be drawn on the basis of results obtained about anti-microbial activity of Pachavalkal and modified Panchavalkal in three different extracts.Trial registration: It is taken, Ref. No. MGACHRC/IEC/February-2021/193-A
A reminder of life-threatening reaction of hymenoptera sting cause anaphylaxis shock
Authors: Wiryandari Ni Putu Nita , Suryana Ketut , Wulandari Dewi Catur
Published: June 2022

The prevalence of hymenoptera sting in general population still high. Large local reaction (LLR) is more common manifestation but can also cause anaphylactic shock and loss of consciousness, or even cardiac or respiratory arrest that all is defined as severe systemic sting reaction (SSR). The risk is generally considered low for future SSR in subjects with LLR but need to be considered and recognized immediately. We reported a case of 39-year-old women was stung by a wasp when driving motorcycle and presented to emergency room with anaphylactic shock (fulfill the amended NIAID/FAAN criteria). She also stung by wasp 2 years ago and cause her left upper and lower arms became swollen slowly and improved 3 days later after treatment with allergy drugs. Electrocardiography result refer to sinus bradycardia. Significant laboratory result showed hypokalemia (2.9 mmol/l). Patient treated by injecting epinephrine intramuscularly and glucocorticoids to preventing protracted symptoms and biphasic reactions.