bluuebunny/crossref_metadata_2025 huggingface dataset:
Manpower, financial, material resources, and participation level in national fitness: a fuzzy-set QCA approach
Authors: Xu Ping , Zhu Liang , Yang Liu , Yan Jin
Published: October 2024

Background

In the era of economic globalization, major public health events—such as the Ebola epidemic, the avian influenza epidemic, the “SARS” epidemic, and the COVID-19 pandemic—occur more frequently, severely endangering human life safety and health and making global public health governance a major survival issue of universal concern. Therefore, governments have included the improvement of national health in their sustainable development goals, and its important position in global and national health policies has become increasingly prominent. However, the most common non-medical intervention taken by the government is to encourage people to actively participate in physical fitness activities to prevent disease and improve health. Therefore, how to improve the level of participation in national fitness is not only a hot topic in the academic community, but also a work content that governments around the world attach great importance to.

Objectives

To reveal the complex interaction of the factors affecting the participation level in national fitness and obtain the linkage and adaptation mode of multiple conditions.

Study design

Starting from the three elements of manpower, financial, material resources, combined with the characteristics of the organizational behavior of local governments in China, this study puts forward an integrated analysis framework to understand the difference of the participation level in national fitness in various provinces and regions.

Methods

Fuzzy-set Qualitative Comparative Analysis (fsQCA) is used to carry out configuration analysis on the participation level in national fitness in 31 provinces and regions in China.

Results

First, no single necessary condition can explain the results, whether for high-or low-level national fitness participation. Second, the construction of social sports instructors, public financial support for mass sports, and the supply of sports venues are the core conditions for improving the participation level in national fitness. Third, high-level participation of national fitness is carried out in five ways in China’s provinces.

Conclusion

These findings enrich the literature on improving the participation level in national fitness, and provide useful practical enlightenment for the local governments to increase the participation level in national fitness.
Case Report: Optimal utilization of marginal lung allografts by considering donor–recipient PGD risk compatibility and by mitigating allograft and recipient inflammatory risk
Authors: Braithwaite Sue A. , Jennekens Jitte , Berg Elize M. , de Heer Linda M. , Ramjankhan Faiz , de Jong Michel , Luc Charlier Jean , Dessing Thomas C. , Veltkamp Marcel , Scheren Amy S. , Ruigrok Dieuwertje , Schönwetter Rob H. J. , Buhre Wolfgang F. F. A. , van der Kaaij Niels P.
Published: October 2024

Reducing the risk of high-grade primary graft dysfunction (PGD) is vital to achieve acceptable short- and long-term outcomes for recipients following lung transplantation. However, the utilization of injured lung allografts, which may confer a higher risk of PGD, must be considered due to the disparity between the increasing number of patients requiring lung transplantation and the limited donor pool. We describe a case in which highly marginal lung allografts were utilized with a good post-transplant outcome. Donor–recipient PGD risk compatibility was taken into consideration. Normothermic ex vivo lung perfusion (EVLP) was utilized to functionally assess the allografts. A second cold ischemia time following EVLP was avoided by converting the EVLP mode to a hypothermic oxygenated perfusion setup from which the lungs were transplanted directly. We attempted to mitigate lung ischemia-reperfusion injury in the recipient by employing cytokine adsorption both during the EVLP and intraoperatively during the implant procedure. In this case report, we describe our hypothermic oxygenated perfusion setup on EVLP for the first time. Furthermore, we describe the utilization of cytokine adsorption in two phases of the same transplant process.
Detection of hand motion during cadaveric mastoidectomy dissections: a technical note
Authors: On Thomas J. , Xu Yuan , Gonzalez-Romo Nicolas I. , Gomez-Castro Gerardo , Alcantar-Garibay Oscar , Santello Marco , Lawton Michael T. , Preul Mark C.
Published: October 2024

Background

Surgical approaches that access the posterior temporal bone require careful drilling motions to achieve adequate exposure while avoiding injury to critical structures.

Objective

We assessed a deep learning hand motion detector to potentially refine hand motion and precision during power drill use in a cadaveric mastoidectomy procedure.

Methods

A deep-learning hand motion detector tracked the movement of a surgeon's hands during three cadaveric mastoidectomy procedures. The model provided horizontal and vertical coordinates of 21 landmarks on both hands, which were used to create vertical and horizontal plane tracking plots. Preliminary surgical performance metrics were calculated from the motion detections.

Results

1,948,837 landmark detections were collected, with an overall 85.9% performance. There was similar detection of the dominant hand (48.2%) compared to the non-dominant hand (51.7%). A loss of tracking occurred due to the increased brightness caused by the microscope light at the center of the field and by movements of the hand outside the field of view of the camera. The mean (SD) time spent (seconds) during instrument changes was 21.5 (12.4) and 4.4 (5.7) during adjustments of the microscope.

Conclusion

A deep-learning hand motion detector can measure surgical motion without physical sensors attached to the hands during mastoidectomy simulations on cadavers. While preliminary metrics were developed to assess hand motion during mastoidectomy, further studies are needed to expand and validate these metrics for potential use in guiding and evaluating surgical training.
Spectral expansion methods for prediction uncertainty quantification in systems biology
Authors: Deneer Anna , Molenaar Jaap , Fleck Christian
Published: October 2024

Uncertainty is ubiquitous in biological systems. For example, since gene expression is intrinsically governed by noise, nature shows a fascinating degree of variability. If we want to use a model to predict the behaviour of such an intrinsically stochastic system, we have to cope with the fact that the model parameters are never exactly known, but vary according to some distribution. A key question is then to determine how the uncertainties in the parameters affect the model outcome. Knowing the latter uncertainties is crucial when a model is used for, e.g., experimental design, optimisation, or decision-making. To establish how parameter and model prediction uncertainties are related, Monte Carlo approaches could be used. Then, the model is evaluated for a huge number of parameters sets, drawn from the multivariate parameter distribution. However, when model solutions are computationally expensive this approach is intractable. To overcome this problem, so-called spectral expansion (SE) methods have been developed to quantify prediction uncertainty within a probabilistic framework. Such SE methods have a basis in, e.g., computational mathematics, engineering, physics, and fluid dynamics, and, to a lesser extent, systems biology. The computational costs of SE schemes mainly stem from the calculation of the expansion coefficients. Furthermore, SE effectively leads to a surrogate model which captures the dependence of the model on the uncertainty parameters, but is much simpler to execute compared to the original model. In this paper, we present an innovative scheme for the calculation of the expansion coefficients. It guarantees that the model has to be evaluated only a restricted number of times. Especially for models of high complexity this may be a huge computational advantage. By applying the scheme to a variety of examples we show its power, especially in challenging situations where solutions slowly converge due to high computational costs, bifurcations, and discontinuities.
Evaluation of agreement for radiographic lesions and risk for racing in thoroughbred yearling sale repository radiographs
Authors: Argue Brodie J. , Ahern Benjamin J.
Published: October 2024

Introduction

The veterinary yearling pre-sale repository radiographs have the potential to impact both vendor and prospective purchaser. The primary aim of this study was to determine inter-observer agreement for orthopaedic lesions identified in thoroughbred yearling repository radiographs. A secondary goal was to determine agreement when using a pre-defined risk rating classification.

Methods

Three experienced specialist equine surgeons (2 ACVS & 1 FANZCVS) interpreted thirty repository radiographs once each for radiographic abnormalities. Each radiographic abnormality was given an associated risk assessment for future racing performance.

Results

The use of a pre-defined risk rating grading scale resulted in good to excellent agreement as observers reached a consensus on risk ratings for lesions 97.1% of the time. The highest agreement was for the proximal interphalangeal joint and distal interphalangeal joint, with 99.9 and 98.2% agreement, respectively. The tarsal region was the joint with the highest disagreement with respect to pathology, with observers disagreeing 5.2% of the time.

Discussion

This study found that experienced veterinary surgeons reliably agreed on the absence of lesions but showed disagreement on the specific risk rating of common lesions.
mRNA expression profiles in muscle-derived extracellular vesicles of Large White and wild boar piglets reveal their potential roles in immunity and muscle phenotype
Authors: Yu Naixiang , Chang Xiaolong , Hu Jianchao , Li Jianjun , Ma Junwu , Huang Lusheng
Published: October 2024

Introduction

Extracellular vesicles (EVs) known for their pivotal role in intercellular communication through RNA delivery, hold paramount implications for understanding muscle phenotypic variations in diverse pig breeds.

Methods

In this study, we compared the mRNA expression profiles of longissimus dorsi muscles and muscle-derived extracellular vesicles (M-EVs), and also examined the diversity of enriched genes in M-EVs between weaned wild boars and commercial Large White pigs with respect to their numbers and biological functions.

Results

The results of the study showed that the variation in the expression profiles of mRNAs between muscles and M-EVs was much greater than the variability between the respective breeds. Meanwhile, the enrichment trend of low-expressed genes (ranked <1,000) was significantly (p-value ≤ 0.05) powerful in M-EVs compared to highly expressed genes in muscles. In addition, M-EVs carried a smaller proportion of coding sequences and a larger proportion of untranslated region sequences compared to muscles. There were 2,110 genes enriched in M-EVs (MEGs) in Large White pigs and 2,322 MEGs in wild boars, with 1,490 MEGs shared interbreeds including cyclin D2 (CCND2), which inhibits myogenic differentiation. Of the 89 KEGG pathways that were significantly enriched (p-value ≤ 0.05) for these MEGs, 13 unique to Large White pigs were mainly related to immunity, 27 unique to wild boars were functionally diverse but included cell fate regulation such as the Notch signaling pathway and the TGF-beta signaling pathway, and 49 were common to both breeds were also functionally complex but partially related to innate immunity, such as the Complement and coagulation cascades and the Fc gamma R-mediated phagocytosis.

Discussion

These findings suggest that mRNAs in M-EVs have the potential to serve as indicators of muscle phenotype differences between the two pig breeds, highlighting the need for further exploration into the role of EV-RNAs in pig phenotype formation.
Vehicle and Pedestrian Traffic Signal Performance Measures Using LiDAR-Derived Trajectory Data
Authors: Saldivar-Carranza Enrique D. , Desai Jairaj , Thompson Andrew , Taylor Mark , Sturdevant James , Bullock Darcy M.
Published: October 2024

Light Detection and Ranging (LiDAR) sensors at signalized intersections can accurately track the movement of virtually all objects passing through at high sampling rates. This study presents methodologies to estimate vehicle and pedestrian traffic signal performance measures using LiDAR trajectory data. Over 15,000,000 vehicle and 170,000 pedestrian waypoints detected during a 24 h period at an intersection in Utah are analyzed to describe the proposed techniques. Sampled trajectories are linear referenced to generate Purdue Probe Diagrams (PPDs). Vehicle-based PPDs are used to estimate movement level turning counts, 85th percentile queue lengths (85QL), arrivals on green (AOG), highway capacity manual (HCM) level of service (LOS), split failures (SF), and downstream blockage (DSB) by time of day (TOD). Pedestrian-based PPDs are used to estimate wait times and the proportion of people that traverse multiple crosswalks. Although vehicle signal performance can be estimated from several days of aggregated connected vehicle (CV) data, LiDAR data provides the ability to measure performance in real time. Furthermore, LiDAR can measure pedestrian speeds. At the studied location, the 15th percentile pedestrian walking speed was estimated to be 3.9 ft/s. The ability to directly measure these pedestrian speeds allows agencies to consider alternative crossing times than those suggested by the Manual on Uniform Traffic Control Devices (MUTCD).
High-Precision Photonics-Assisted Two-Step Microwave Frequency Measurement Combining Time and Power Mapping Method
Authors: Yang Zhangyi , Liu Zuoheng , Jiang Yuqing , Liu Hanbo , Li Jiaqi , Dong Wei
Published: October 2024

Photonics-assisted methods for microwave frequency measurement (MFM) show great potential for overcoming electronic bottlenecks and offer promising applications in radar and communication due to their wide bandwidth and immunity to electromagnetic interference. In common photonics-assisted MFM methods, the frequency-to-time mapping (FTTM) method has the capability to measure various types of signals, but with a trade-off between measurement error, measurement range, and real-time performance, while the frequency-to-power mapping (FTPM) method offers low measurement error but faces great difficulty in measuring signal types other than single-tone signals. In this paper, a two-step high-precision MFM method based on the combination of FTTM and FTPM is proposed, which balances real-time performance with measurement precision and resolution compared with other similar works based on the FTTM method. By utilizing high-speed optical sweeping and an optical filter based on stimulated Brillouin scattering (SBS), FTTM is accomplished, enabling the rough identification of multiple different signals. Next, based on the results from the previous step, more precise measurement results can be calculated from several additional sampling points according to the FTPM principle. The demonstration system can perform optical sweeping at a speed of 20 GHz/μs in the measurement range of 1–18 GHz, with a measurement error of less than 10 MHz and a frequency resolution of 40 MHz.
Digital transformation of the enterprise: the impact of technology on the effi ciency of business processes
Authors:   Hopper IT, Russia, Dubna, Radchenko S.T.
Published: October 2024

Digitalization of business processes helps companies to reach a new level, meet rapidly changing conditions, and communicate more eff ectively with the audience. Today, this is already a natural condition for business development, which underlines the relevance of this study. The article discusses the general advantages of digitalization of business, which justify the need for these processes in a modern company, regardless of the scope of its activities. In addition, the main elements of the digital transformation of business processes, which are currently the most widespread and infl uential, are summarized. Each of these elements of digital transformation has a direct or indirect impact on all business processes. We will also trace the basic stages of the digitalization process and focus on specific examples of their implementation in the practice of the IT laboratory.
Application of carbon dioxide to improve the technology of oil recovery during well treatment
Authors:   Astrakhan State Technical University, Ilyasov T.M. , Pokoptsev A.A. ,   Astrakhan State Technical University, Taskalieva F.Kh. ,   Astrakhan State Technical University, Farziev A.G-O. ,   Astrakhan State Technical University
Published: October 2024

At the current stage of development of the oil and gas industry in the world, the processing and utilization of carbon dioxide at the fi eld itself is of interest, which makes it possible to save energy resources during its capture and injection into the well space, which is important for Russia due to the remoteness of the main part of the fi elds. Due to the release of associated gases, in particular, hydrogen, there is a possibility to generate additional energy for own needs at the fi eld and, in addition, to minimize greenhouse gas emissions. It is noted that supercritical fl uid carbon dioxide has a list of advantages, including the absence of toxicity, fi re, explosion hazard, as well as low cost and availability and serves as an environmentally safe solvent. To the technological equipment of surface and underground placement for injection of fl uid carbon dioxide can be attributed the system of its capture, purifi cation, storage tanks, compressor and / or pumping stations. The article recommends rational ways to increase the effi ciency of carbon dioxide capture and injection of carbon dioxide into the well space, as well as the choice of hardware for these purposes, based on a systematic analysis of literature data, staged pilot series and industrial testing of options for solving these problems. Realization of the gas method of oil production growth will lead to several-fold increase in production. The recommended technology will make it possible to improve environmental safety by isolating the emission of CO2 emitted in the oil industry. From the economic point of view the low cost of carbon dioxide, its recycling, possibility of realization at any stage of fi eld operation, high quality parameters of marketable oil feedstock are attractive.
Relevance of remote work format in 2024
Authors:   Strategic development and career expert, Marchenko L.I.
Published: October 2024

Today, more and more employees prefer remote work, while employers have concerns. Today, only 40% of people work from the offi ce, the percentage of people working remotely is growing higher every year. The article shows the pros and cons of the remote format and provides recommendations for organizing work based on the author’s own experience.
Aspects of reducing the attractiveness of vocational education among applicants
Authors:   «Your human resource», Moscow, Koretskaya E.O.
Published: October 2024

It is generally accepted that educational institutions around the world and in Europe are exemplary. But is it? “Mystery shoppers” identifi ed gaps, delays and errors in the communication of these universities with potential applicants, which means lost profi ts and reduces their prestige.
THE SUBSYSTEM OF DISPATCHING THE MANAGEMENT OF ROAD MAINTENANCE SERVICES. EXPERIENCE AND PROSPECTS OF ARTIFICIAL INTELLIGENCE APPLICATION
Authors:   Closed Joint Stock Company Group of Companies «NAVIGATOR», Shevlyakov Aleksandr Nikolayevich
Published: October 2024

The author of the article provides examples of the practical implementation of an ecosystem that includes technological products for detecting defects in the roadway. The problems of their implementation are described, the architecture of the module that monitors the roadway is developed, the results of the implementation of subsystems for dispatching the management of road maintenance services, in terms of the use of artificial intelligence, are presented.
STATISTICAL ANALYSIS OF ACCIDENT DATA IN APPLIED TASKS
Authors:   Saint-Petersburg State University of Architecture and Civil Engineering, Lukashov Bogdan Vitalevich , Evtyukov Sergey Arkadevich ,   Saint-Petersburg State University of Architecture and Civil Engineering, Lukashov Rodion Vitalievich ,   St. Petersburg State University, Pavlov Semyon Anatolyevich ,   St. Petersburg State University
Published: October 2024

Investigation of the patterns of occurrence of traffic accidents on various highways, analysis of the level of traffic safety on expressways.
FEATURES OF RESTORING THE CRANKSHAFT OF AN AUTOMOTIVE ENGINE USING LASER SURFACE METHOD
Authors:   Oryol State University named after I.S. Turgenev, Novikov Alexander Nikolaevich , Artsybashev Andrey Konstantinovich ,   Oryol State University named after I.S. Turgenev
Published: October 2024

The article provides a comparative analysis of the restoration of crankshaft journals using arc and laser surfacing. The features of the existing technology for restoring crankshaft journals by laser cladding, its advantages and disadvantages are considered. Proposals are given for modifying the existing technology for restoring internal combustion engine crankshafts.
ASSESSING THE SATISFACTION LEVEL OF INTEGRATED SEA PRACTICE MONITORING INFORMATION SYSTEMS IN MARITIME EDUCATION AND TRAINING: THE PIECES FRAMEWORK
Authors: Palapa Arika
Published: October 2024

Maritime education and training are aimed at producing and enhancing seafarers' competencies. Monitoring training activities is an essential aspect, yet its execution still relies on non-integrated email systems. When monitoring is not integrated and solely relies on email, the monitoring process becomes less effective. This research aims to develop and test an application called OTMON (Online Monitoring) for overseeing maritime education and training (MET). The research method utilizes a research and development (R&D) approach with the ADDIE phases: Analyze, Design, Develop, Implement, and Evaluate. System needs analysis employs the PIECES approach to fulfill monitoring requirements in MET activities. A total of 67 respondents participated in this research. The findings indicate that users perceive a high level of satisfaction when using the OTMON application. The application can be optimally utilized as it employs the PIECES approach. The research implication is that online monitoring applications can be considered as an alternative for monitoring maritime education and training.
APLIKASI 3D GAME SIMULASI UNTUK PENGENALAN PROFESI PADA ANAK USIA DINI
Authors: Hanafi Ibnu , Vitianingsih Anik Vega , Choiron Achmad , Cahyono Dwi , Wikanningrum Anggit
Published: October 2024

Pendidikan pengenalan profesi di usia dini penting untuk pembentukan karakteranak. Game edukasi dapat menjadi media pembelajaran yang menarik dan interaktifuntuk mengenalkan berbagai profesi kepada anak. Tujuan dari penelitian ini adalahmengembangkan aplikasi game untuk mengubah konten edukasi menjadi pengalamanbelajar interaktif yang dapat diakses melalui Android. Metode penelitian mengadopsimetode Multimedia Development Life Cycle (MDLC) yang terdiri dari penentuan konsepaplikasi, perancangan objek 3 dimensi, pengumpulan bahan, pengembangan aplikasi, ujicoba aplikasi dan penerbitan aplikasi. Hasil penelitian yang didapatkan antara lain:validasi pemahaman berbagai profesi memperoleh persentase 83% dengan kriteria valid,validasi interaksi kontrol memperoleh persentase 74% dengan kriteria valid, validasimenyukai penggunaan game memperoleh persentase 84% dengan kriteria valid, danvalidasi keinginan bermain memperoleh persentase 72% dengan kriteria valid. Dari hasiluji validasi yang telah dilakukan terhadap 30 responden, menunjukkan nilai rata-ratasebesar 79,44% dan dapat disimpulkan bahwa game ini termasuk dalam kualifikasi layakdigunakan sebagai media pembelajaran yang lebih efisien.
Oraciones multimodales la compleción gestual como recurso comunicativo
Authors: Rosková Magdalena , Satti Ignacio
Published: October 2024

En este trabajo estudiamos enunciados multimodales en donde un elemento gestual cumple una función sintáctica dentro de una oración verbalmente incompleta. Como ha sucedido con otros fenómenos típicos de la lengua oral, su estudio ha sido desdeñado por considerarse un problema de actuación: la gestualidad sería simplemente un recurso para subsanar el déficit del hablante para encontrar un elemento verbal. Al contrario, nuestro análisis muestra que las compleciones gestuales constituyen un recurso comunicativo con funciones propias (la intensificación, la atenuación y el favorecimiento de la progresión discursiva) que trascienden el uso de un posible equivalente verbal. Al adoptar la perspectiva émica de la lingüística interaccional, argumentamos que estos enunciados son considerados como completos por parte de los participantes del evento comunicativo y, como tales, constituyen oraciones multimodales. Así, nuestro trabajo propone la consideración de la gestualidad dentro del estudio de la gramática. Los datos proceden de tres corpus audiovisuales que incluyen muestras de diferentes variedades del español.
Comparativas de desigualdad en la lengua de señas argentina. Una aproximación descriptiva
Authors: Coronel Magdalena , Malalel Deborah , Mazuecos Ana Laura , Dalmau María de los Ángeles
Published: October 2024

Siguiendo a Quer et al (2017), en términos cognitivos o semánticos, las comparaciones pueden definirse como un acto mental mediante el cual a dos entidades se les asigna una posición en una escala: si las posiciones en la escala son diferentes, hablaremos de comparaciones de desigualdad; si ocupan la misma posición, nos encontraremos frente a comparaciones de igualdad. En este trabajo nos proponemos realizar una aproximación descriptiva a las construcciones comparativas de desigualdad de la Lengua de Señas Argentina (LSA).
La ausencia de descripción de construcciones comparativas es general en el ámbito de las lenguas de señas (LLSS), con excepción de la Lengua de Señas Italiana y la Lengua de Señas Turca. Nuestras observaciones preliminares coinciden con las descripciones de estas dos LLSS en relación con las diversas maneras de expresar la comparación de desigualdad. Al respecto, observamos tres opciones, que pueden coaparecer en una misma oración. Por un lado, la comparación puede expresarse a través de la utilización de una seña manual escalar que se incorpora al núcleo de la comparación. Por otro lado, es posible utilizar la seña del cuantificador comparativo MÁS, adyacente al núcleo de la comparación o noción comparada. Finalmente, la comparación puede manifestarse a través de una estrategia locativa junto con señas deícticas.
A utilização da VNI em UTI's pediátricas: uma revisão integrativa
Authors: Lopes Sávio Maia , Carneiro Raul Mateus de Sousa , Carneiro Helen Regina Marques , Bezerra Cyelle Mainã Silva , Fonseca Bruna Gabrielle Borges , Silva Maycom Carvalho da , Pinheiro Katia Rosa , Góes Vitória Serena Nunes , Miranda Pedro Henrique de Sousa , Furtado Marcos Vinícius da Conceição
Published: October 2024

Apontar as indicações terapêuticas da VNI para pacientes internados em UTIP que cursaram com insuficiência respiratória pediátrica. O presente estudo trata-se de uma revisão integrativa da literatura, seguindo como pergunta norteadora: Quais as atuais recomendações para o uso da oxigenoterapia de alto fluxo e ventilação não invasiva em pacientes pediátricos internados em UTIP?. A coleta dos artigos foi realizada no período de maio a junho de 2024, nos idiomas português, inglês e espanhol. Bases de dados escolhidas: LILACS/BVS, SciELO, PubMed e Cochrane. Utilizou-se os seguintes Descritores/DeCS: Unidades de Terapia Intensiva; Unidades de Terapia Intensiva Pediátrica; Ventilação Não Invasiva; Respirador Artificial; combinados com operador booleano “AND”. A partir dos 11 artigos desta Revisão Integrativa, foi possível discorrer sobre as indicações da oxigenoterapia de Alto Fluxo e Ventilação Mecânica Não Invasiva (VNI) para pacientes pediátricos que evoluíram com casos de insuficiência respiratória e, as implicações desta terapêutica na UTIP. Dessa forma, pode-se concluir que a VNI e a oxigenoterapia de alto fluxo nas UTI pediátricas, quando voltadas para o público infantil e lactante com perfis clínicos heterogêneos, mostraram-se eficazes para quadros de baixo a moderado risco de complicações respiratórias e redução da necessidade da VM invasiva.
Políticas públicas de acesso à saúde mental no estado do Amazonas: um estudo de revisão da literatura
Authors: Viana Adriane Vinhote Moraes , Antunes Lorena Martins de Sá Torres , Teixeira Elberth Henrique Miranda , Nascimento Tysciana Alice de Brito , Alves Raniele Alana Lima , Queiroz Mayda de Oliveira , Pereira Pablo Gnutzmann , Caires Nely Cristina Medeiros , Moysés Rosana Pimentel Correia , Martins Fabiana Manica
Published: October 2024

A situação das pessoas que necessitam de serviços em saúde mental, tanto nos países desenvolvidos quanto em desenvolvimento é calamitosa. A reforma psiquiátrica brasileira é um movimento de luta política e ideológica que busca a troca do tratamento baseado em isolamento por uma visão mais humanizada e têm como objetivo inserir os indivíduos com desordens psiquiátricas na sociedade. O presente trabalho tem como obejtivo analisar por meio de uma revisão da literatura as políticas públicas de saúde mental voltadas para o acesso da população amazonense aos serviços de saúde e identificar as dificuldades e lacunas da rede de assistência no estado do Amazonas. Para isso, realizou-se levantamento de trabalhos publicados na literatura entre 2010 e 2023 nas bases de dados PUBMED, SciELO, Lilacs, BVS-Bireme e Portal de Periódicos da CAPES. Os descritores “saúde mental”, “política de saúde”, “serviços de saúde mental”, “Amazonas” e “Brasil” foram empregados em inglês e português, de acordo com a base utilizada. A partir da busca, foram encontrados 406 artigos, contudo, somente três deles atenderam aos critérios de inclusão e exclusão estabelecidos. Entre os desafios citados nos estudos, estão a falta de integração entre os níveis de atenção, carência de profissionais qualificados na área e incapacidade da atenção primária em oferecer suporte adequado para atendimento de transtornos mentais leves. A análise demonstrou que os desafios na saúde mental no Amazonas são persistentes e compromete a eficácia dos serviços, sendo ideal realizar revisão do modelo de gestão. Além disso, há escassez de estudos atualizados na literatura.
Avaliação da interferência medicamentosa provocada pelo uso recorrente de ácido ascórbico em exames laboratoriais
Authors: Smith Nathálya Helena Nina , Maranhão Jhade D'umar Ferreira , Oliveira Rosicleide Nogueira de , Araújo Rian Peres , Ribeiro Larissa Siara Oliveira , Silveira Neto Sebastião , Santos Hivylla Lorrana Ferreira dos , Sousa Luis Artur Ferreira de , Lobato Luis Felipe Lima
Published: October 2024

A automedicação no Brasil é extremamente comum e está disseminado na população desde o início da comercialização de medicamentos neste país. No entanto com a chegada da pandemia de COVID-19, houve uma crescente procura para utilização de fármacos, tendo como destaque o ácido ascórbico (AA), comumente conhecido como vitamina C, um medicamento barato, de fácil acesso a todos e tendo como premissa de otimizar o sistema imunológico. Entretanto, o uso recorrente dessa droga, destaca-se por provocar uma significativa interferência em exames laboratoriais. Este trabalho tem por objetivo avaliar a interferência medicamentosa provocada pelo uso recorrente de ácido ascórbico em exames laboratoriais. Metodologia: O presente estudo foi baseado em uma revisão de literatura integrativa do tipo descritiva, tendo abordagem qualitativa com artigos registrados nas seguintes bases de dados: PubMed, Google Acadêmico e SciELO, publicados no idioma português e inglês, e de relevância para a defesa do tema proposto. Discussão: Em nossos resultados, verificou-se interferência em testes laboratoriais apresentando valores elevados para glicose, sódio, potássio, cloretos, cálcio e creatinina. E valores diminuídos para colesterol total, colesterol HDL, colesterol LDL, triglicerídeos e lactato. Resultados falsos negativos foram observados com a presença de AA na urina para a detecção de glicosúria, assim como também na determinação de analitos bioquímicos séricos, como o ácido úrico e bilirrubina, apresentando interferência tanto analítica quanto fisiológica. Conclusão: Podemos concluir que o uso recorrente de AA, sem a prescrição e acompanhamento médico pode ser um grande perigo, sobretudo no que se refere às alterações em exames laboratoriais, podendo provocar resultados duvidosos, elevados ou reduzidos e falsos negativos, o que tende a comprometer significativamente no diagnóstico de doenças, dificultando a investigação clínica e prejudicando consideravelmente a saúde de modo geral.
Alterações epigenéticas associadas ao Transtorno Bipolar decorrente de traumas na infância
Authors: Brito Dandhara de Carvalho Montalvão , Souza Gustavo Reis Branco de , Santos Filho Moezio Vasconcellos Costa
Published: October 2024

O transtorno bipolar, conhecido por seus episódios de mania e depressão sofre influências genéticas e ambientais para o seu desenvolvimento. Com isso, os fatores externos, como eventos adversos ocorridos na infância contribuem com o aparecimento de sinais e sintomas da patologia. Para tanto, este trabalho consiste em uma revisão integrativa da literatura que possui o propósito de desmitificar como os traumas na infância implicam na genética e epigenética do transtorno bipolar. Dessa maneira, é apontado que a ocorrência de eventos adversos durante os primeiros anos de vida modelam a atividade cerebral e os mecanismos relacionados à ela. Genes regulatórios de glucocórticoides – entre eles os genes FKBP5, NR3C1 e MAO - vem sendo estudados como mediadores da resposta estressora e reguladores dos níveis de cortisol liberado pelo organismo, em adendo, vem sendo estudada a ligação entre esses genes e suas modificações epigenéticas em pacientes psiquiátricos. Todavia, A influência desses eventos na epigenética que medeia o transtorno bipolar ainda é incerta, por isso pesquisadores buscam compreender quais genes e mecanismos estão envolvidos nessa associação e como eles alteram a fisiologia cerebral, promovendo o aparecimento do transtorno bipolar.
O papel da Rivastigmina no tratamento do paciente com demência por Doença de Parkinson
Authors: Meneses Maria Íris de Assunção , Moraes Ahedja Galvão , Pontes Terceiro Cicero Ferrucio , Monteiro Débora Katarine Trindade Lins , Lima Lelia Pereira de , Horta Wagner Gonçalves
Published: October 2024

A demência por doença de Parkinson (DDP) é uma condição que impacta significativamente a qualidade de vida dos pacientes. Nesse contexto, buscou-se identificar as opções terapêuticas mais utilizadas atualmente, avaliar sua eficácia no controle da doença, reconhecer os efeitos adversos e determinar o momento ideal para administração, além de evidenciar o prognóstico das terapêuticas listadas no tratamento da DDP. Foi conduzida uma revisão integrativa da literatura, destacando a rivastigmina como uma opção terapêutica essencial aprovada pela FDA para demência leve a moderada associada à DDP. A rivastigmina demonstrou melhorias nos sintomas cognitivos e comportamentais, com uma redução relativa nos efeitos adversos gastrointestinais na forma transdérmica. No entanto, observou-se um subtratamento significativo da DDP, ressaltando a necessidade de uma oferta farmacológica mais abrangente. Além disso, discutiu-se a importância do cuidado integral do paciente, incluindo terapias não farmacológicas. Concluiu-se, portanto, que a rivastigmina é uma opção terapêutica essencial, enfatizando a importância de uma abordagem integrada para melhorar a qualidade de vida dos pacientes e de seus cuidadores.
Síndrome hipereosinofílica: relato de caso
Authors: Gurgel Antonio Carlos Gouvea do Amaral , Freitas José Maurício Nogueira , Costa Marina Barbosa da , Ottoni Matheus Cardoso
Published: October 2024

As doenças mieloproliferativas crônicas, incluindo a síndrome hipereosinofílica (SHE), são distúrbios caracterizados pela produção anormal de células sanguíneas. A SHE é uma condição rara e heterogênea, com eosinofilia persistente e danos aos órgãos. Sua fisiopatologia envolve mutações genéticas e citocinas estimuladoras da produção de eosinófilos. Apesar dos avanços na compreensão, a etiologia permanece incompleta. As manifestações clínicas são variadas e inespecíficas, contribuindo para diagnóstico tardio, porém, pode-se observar um acometimento principalmente nos sistemas gastrointestinal, cutâneo, cardíaco, pulmonar e/ou neurológico. Critérios diagnósticos incluem eosinofilia persistente, exclusão de causas secundárias e sinais de disfunção orgânica. O tratamento visa reduzir sintomas e contagem de eosinófilos, podendo envolver corticoterapia ou terapias direcionadas, como Imatinib para variantes específicas. O presente trabalho tem por objetivo realizar um relato de caso de uma paciente diagnosticada com síndrome hipereosinofílica, e além disso, mostrar as manifestações da patologia no caso em questão, através de alterações no exame físico, exames laboratoriais e de imagem.
Relação entre hábitos orais e o desenvolvimento de maloclusões em crianças: revisão de literatura
Authors: Campos Fernanda , Ferreira Ana Clara Caetano , Ribeiro Euhler de Farias Rodrigues , Santos Ester Lima dos , Neubert Gustavo Falcão da Cunha , Caetano Igor de Morais , Xavier Leonardo de Souza
Published: October 2024

Hábitos orais comuns, como sucção de dedo, uso prolongado de chupetas e respiração bucal, são frequentemente associados ao desenvolvimento de maloclusões, que podem afetar a oclusão dentária e a função mandibular. O estudo revisa a literatura existente, analisando dados de pesquisas anteriores e estudos clínicos sobre como esses hábitos influenciam a posição dos dentes e a estrutura mandibular. Observa-se que a sucção de dedo, por exemplo, pode causar protrusão dos incisivos superiores e retroinclinação dos incisivos inferiores, enquanto a respiração bucal pode levar a alterações na forma do maxilar e problemas de alinhamento dentário. A pesquisa também destaca a importância de intervenções precoces e programas educativos para pais e cuidadores, visando a correção de hábitos prejudiciais antes que causem alterações significativas na oclusão dentária. Com base nisto, o objetivo deste trabalho é investigar a relação entre hábitos orais e o desenvolvimento de maloclusões em crianças, avaliando como comportamentos orais comuns influenciam a saúde dentária e a oclusão dentária. Conclui-se que a modificação ou eliminação desses hábitos é crucial para prevenir o desenvolvimento de maloclusões e promover uma saúde oral adequada desde a infância. Recomenda-se a implementação de estratégias preventivas e a colaboração entre dentistas e profissionais de saúde infantil para minimizar os riscos associados a esses hábitos.
المرأة في خراسان ودورها العلمي والثقافي منذ مستهل القرن الثالث الهجري إلى القرن السادس الهجري
Authors: الرديني ريم سعود
Published: October 2024

تهدف الدراسة إلى تحليل دور المرأة في المجتمع الخراساني خلال فترة حكم الدولة الإسلامية، وتركز على مجالات العلوم والثقافة. استخدمت الدراسة منهجية تاريخية وصفية وتحليلية لفهم الثقافة والمجتمع الخراساني، وتحليل دور المرأة فيه. وتمحور أسئلة البحث حول ما المكانة التي حازتها المرأة الخراسانية خلال فترة حكم الدولة الإسلامية وعلاقتها بالسلطة وما أبرز الأدوار العلمية والثقافية التي اضطلعت بها المرأة الخراسانية؟وما دور المرأة الخراسانية في العلوم الدينية المختلفة في ذلك العصر؟ أظهرت النتائج أن المرأة الخراسانية كان لها دور بارز في العلوم الدينية والفنون والآداب، واستفادت الجواري من مكانتهن للتعبير عن هويتهن وتأكيد ذواتهن من خلال العلم والثقافة. كما استثمرت السلطة هذه العلاقة بين المرأة الأديبة والعالمة والرجل بشكل إيجابي، مما أتاح للمرأة الحرة مساحة كافية من الحرية لممارسة العلم بمختلف تخصصاتها، وجعل دور النساء الحرائر يتماشى مع القيم المراد تكريسها في المجتمع الخراساني. أما أدب المرأة فتمحور حول دلالات تكشف عن شخصياتهن وثورتهن على تحفّظات مجتمعهن، وعبرن عن تجاربهن الشعورية الخاصة، وساهمن في تطوير الثقافة والعلم في الإقليم.
إعادة توجيه الدور التنموي للمشروعات الصغيرة والمتوسطة في الدول العربية - السبيل نحو تحقيق التحول الهيكلي واستدامة التنمية
Authors: أبوشماله نواف محمود محمد
Published: October 2024

تقوم المشروعات الصغيرة والمتوسطة بدور فاعل في الإنتاج والتشغيل، وهي أيضاً مساهم أساسي في سلاسل القيمة والتوريد العالميين. ما جعلها تحتل أهمية خاصة لدى صانعي السياسات على مستوى جميع أقاليم العالم بما فيها الدول العربية. الهدف: تهدف الدراسة إلى تقييم فعالية دور المشروعات الصغيرة والمتوسطة في إنجاز التحول الهيكلي وتحقيق استدامة أعلى للتنمية ضمن أبعادها الاقتصادية والاجتماعية والبيئية في الدول العربية، وذلك أسوة بدورها في تجارب الدول المتقدمة والصاعدة. المنهج: وفي سبيل ذلك اعتمدت الدراسة على ثلاثة مناهج أساسية وهي: الوصفي التحليلي، والتحليلي المقارن، إضافة للمنهج الاستنباطي أو الاستدلالي. النتائج: توصلت الدراسة إلى أنه رغم اهتمام الدول العربية، لاسيما خلال العقود الأخيرة، بالمشروعات الصغيرة والمتوسطة، من خلال تأسيس أطر وهيئات حكومية لتنميتها، وإقرار العديد من التشريعات الهادفة لتدعيمها وتذليل الصعوبات التي تواجهها. فإنّ هذه المشروعات مازالت تواجه تحديات هيكلية، تحد من إمكانات تطوير دورها التنموي، وذلك مقابل مساهمتها الحيوية في التقدم الاقتصادي في تجارب الدول المتقدمة والصاعدة. كما انتهت الدراسة إلى تقديم نموذج كلي الطابع يتأسس على التطبيقات المعاصرة للسياسات الصناعية الحديثة، يعالج تلك القيود ويضمن أيضا تراكم وتكامل الجهود العربية الموجهة لتلك المشروعات، وذلك ضماناً لتحقق الهدف المطلوب المتمثل في توثيق العلاقة بين جهود تنمية هذه المشروعات من جانب، وجهود تحقيق التنمية المستدامة وإنجاز التحول الهيكلي من جانب آخر.
بلاغة المحاكاة وتمثيل الأفكار في الخطاب الروائي المعاصر نارنجة وسيدات القمر لجوخة الحارثي نموذجاً
Authors: شوشة محمد سليم محمد
Published: October 2024

أهداف الدراسة: تهدف هذه الدراسة إلى مقاربة نواتج المحاكاة (Mimesis) والتمثيل (Representation) وأثرهما في بلاغة الخطاب الروائي عبر تطبيق على روايتي نارنجة وسيدات القمر للروائية العمانية جوخة الحارثي()، وتستكشف أثر المحاكاة والتمثيل في إنتاج جماليات الخطاب الروائي وسيرورة بنائه، وكذلك تركز الدراسة على السيرورة التحويلية التي اشتغل عليها الخطاب الروائي لتحويل قيمه الدلالية المجردة وتمثيلها في أحداث ونماذج وشخصيات وحركة وحوار يدور بين الشخصيات داخل الإطار الدرامي. منهج الدراسة: نستعين في تلك المقاربة بمعطيات النقد الأدبي الإدراكي الذي يركز على مبدئي المحاكاة والتمثيل بوصفهما من أهم مبادئ الأدب والفن بشكل عام، وكذلك الاستناد إلى معطيات علم السرد وتحليل الخطاب السردي وبلاغته، على نحو ما نجد في أفكار كل من وين بوث وإيريك أورباخ وبول ريكور وغيرهم.  نتائج الدراسة: كان من نتائج البحث أن كشف عن المسار الذي يتخذه الخطاب الروائي والعقل السردي في تحويل الفكرة أو القيمة المجردة إلى تمثيل سردي أو تكوين مادي ملموس، فتتجسد الفكرة في شخصية أو حدث أو حالة من الصراع الدرامي، أو مشهد أو غيرها من المكونات والتقنيات السردية، كما كشفت الدراسة عن الأثر الناتج عن هذه الإستراتيجيات السردية المتمثلة في المحاكاة والتمثيل وتجسدها في (أثر/منتج تخييلي)، أو تشكيل داخل الخطاب السردي، وركزت الدراسة كذلك على النواتج الجمالية لهذه التقنيات، وما يمكن أن يكون لها من احتمالات تفاعل المتلقي وتأثير على أنماط استقباله. وامتدت نواتج هذه المقاربة إلى كشف تمثيلات الخطاب السردي وأنماط المحاكاة فيه وتحويل الأفكار إلى عنصر سردي، يتجسد في الأسطورة أو الخرافة أو الموروث الشعبي أو التراث الثقافي وحفريات الثقافة العمانية والعربية القديمة، وآثار ما بعد الكولونيالية وتشكُّلات الأيديولوجيا وأنماط الراوي وأنماط التجريب والتجديد، وغيرها من العناصر والتشكيلات السردية.
Mathematical model and general algorithm for solving the problem of processing messages taking into account their value and aging in aircraft systems
Authors: Moroz Boris , Kruhlyk Andrii , Moroz Dmytro , Martynenko Andrii
Published: October 2024

According to research, the world's leading countries, such as the USA, Great Britain, Japan, etc., are actively engaged in the development of automated and automatic systems based on artifi-cial intelligence (AI) in the military sphere and even already have a roadmap for the integration of unmanned systems in the medium and long term prospects. The purpose of this work is to describe a general algorithm for controlling an aircraft system with using controlled discipline taking into account the value characteristics of messages. In addi-tion, an overview of the existing technical solution for the rational division of the algorithm into modules is offered. In the paper considers a mathematical model of the mass service system, where the messages are characterized not only by limit time of execution, but also by another important characteristic - the value of each individual message in the same type of queue. The authors proposed a definition of the efficiency of message processing by system elements. The authors believe that a such model can be quite relevant with the development of unmanned (aircraft) vehicles in the structure of the armed forces of Ukraine. It is especially relevant and appropriate in conditions of active combat operations, where the real situation is very dynamic and the messages entering to the system have different values within the same period of time. The existing technical solution for the optimal (ra-tional) division of the algorithm into modules is considered. This will allow to parallelize the soft-ware development process, test individual modules and make changes in accordance with the latest technical solutions without the need to change the entire system architecture.
Analysis and preparation of data during modeling of plasma-chemical processes of obtaining nanosystems
Authors: Viktor Makarchenko , Larysa Korotka
Published: October 2024

One of the new directions of industrial chemical technology is plasma chemical. Despite sig-nificant experimental and theoretical research, physicochemical processes are complex and not ful-ly understood for scaling and control in mass production. In low-temperature plasma, chemical processes, regularities of reactions, and the basics of plasma chemical technology require computer modeling. The experimental data of natural experiments require additional analysis and prepara-tion for their further application and the construction of adequate simulation models of plasma-chemical processes for the development of nanosystems. In the course of the preliminary experi-ment, which includes two stages, the input and output variables of the application task were exam-ined. A software toolkit has been developed for the analysis of experimental data, which allows col-lecting statistical information and visualizing some processes. The software approaches to building analytical and simulation models of plasma-chemical processes of obtaining nanosystems were considered and implemented. Two possible approaches to the construction of homomorphic models are reviewed: classical and with the use of artificial intelligence. Without limiting judgment, linear and non-linear regres-sion models were reviewed. The first type of model is multiple regression and methods that use reg-ularization. As an alternative, the construction of nonlinear models based on the method of support vectors is proposed. Vector and multi-vector regressions are considered. Multidimensional regres-sion is aimed at studying and constructing a mapping of a multidimensional input feature space into a multidimensional output space. The obtained numerical results were analyzed and it was pro-posed to use nonlinear models of plasma-chemical processes for obtaining nanosystems for com-puter simulation, in particular: multi-vector regression.