bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALYSIS OF THE ACTIVITIES OF DERMATOVENEROLOGISTS PROVIDING MEDICAL CARE TO THE RURAL POPULATION OF THE REPUBLIC OF BASHKORTOSTAN
Authors: N.H. Sharafutdinova , O.R. Mukhamadeeva
Published: May 2024

Relevance. Currently, there is a low staffing of medical organizations with local doctors and medical specialists, including dermatovenerologists. This determines the low availability of primary medical care for the rural population for diseases of the skin and subcutaneous tissue. Purpose of the study. To analyze the activities of dermatovenerologists in providing primary specialized medical care to the rural population for diseases of the skin and subcutaneous tissue in the Republic of Bashkortostan. Materials and methods. The calculation of indicators characterizing the activities of dermatovenerologists in the Republic of Bashkortostan for 2017-2021 was carried out: the provision of the population with dermatovenereologists, staffing of regular positions of dermatovenereologists, staffing with individuals, part-time ratio, share of visits per one rural resident and one patient with skin diseases, number of visits in connection with the disease, in connection with the preventive purpose. Results. Level of supply of dermatovenerologists in the Republic of Bashkortostan in 2021. amounted to 0.54 per 10 thousand population. In recent years, the provision of dermatovenerologists in the rural population remains low: in 11.1% of rural areas there are no dermatovenerologists, and in 31.5% the level of provision is insufficient. For the period 2017-2021 a decrease in the number of visits to a dermatovenerologist for skin diseases was established by 16.3% (per rural resident from 0.29 to 0.24 visits per resident), as well as a decrease in the number of visits to a dermatovenerologist by 22.0% . (from 4.63 to 3.61 visits per patient). An extremely low volume of telemedicine consultations was revealed, which is a significant factor in reducing the availability of medical care for the rural population. Conclusions. In the Republic of Bashkortostan in recent years, the provision of dermatovenerologists for the rural population remains insufficient. Thus, there is a need to develop measures aimed at improving primary specialized medical care provided by dermatovenerologists to the rural population of the Republic of Bashkortostan.
WEDGE DEFECTS OF TEETH
Authors: A.V. Shestukhina
Published: May 2024

Non-carious lesions are common diseases encountered by dentists. One of these diseases manifests itself in the form of a wedge-shaped defect in dental tissue. It is a lesion of tooth enamel of non-carious origin in the cervical area. This disease is easy to detect during the initial examination, since the tooth defect is wedge-shaped [1]. It is important to note that the pathology can have varying degrees of severity, from small depressions to more serious damage. The defect got its name due to the wedge-shaped shape of the lesion. Most often, a wedge-shaped defect appears in premolars or canines. It can affect both the upper and lower sides of the jaw. Research shows that the number of patients with this pathology is increasing every year. According to some authors, the prevalence of wedge-shaped dental defects among the population of the Russian Federation is up to 34% [4]. Many scientists attribute this to improper use of hygiene products and excessive consumption of acidic foods. Recent studies also indicate a connection between the development of wedge-shaped defects and dental overload caused by psycho-emotional tension and stress [3, 5]. This lesion not only affects the aesthetic appearance of the smile, but can also cause increased tooth sensitivity [2]. Scientists have not yet reached a consensus on treatment methods, but in many cases the disease can be prevented using simple preventative methods.
CONTEMPORARY APPROACH TO PERINATAL RISK ESTIMATION BASED ON THE USAGE OF PROGNOSTIC CRITERIA FOR ANTEPARTUM, INTRAPARTUM AND EARLY NEONATAL LOSSES
Authors: A.A. Suverneva , L.V. Dikareva , P.Kh. Gadzhieva , T.S. Kirillova , K.I. Abdulkhalygova
Published: May 2024

The problem of perinatal losses is still actual in obstetrics today. At the same time there are cases of non-estimation or extra-estimation of perinatal risk in obstetrical practice. The usage of famous prognostic systems gives the opportunity to select pregnant women into groups of high risk and provide the necessary organizational and tactic measures. But to define the character of possible complications, to establish the degree of their severity and time of appearance is really impossible.
Objective of the study: to develop a new approach to estimation of perinatal risk based on the determination of prognostic criteria for antepartum and intrapartum fetal death, early neonatal death of a newborn in order to increase the efficacy of predicting of unfavourable perinatal outcomes.
Materials and research methods. The retrospective case-control study in patients with antepartum (n=134) and intrapartum (n=41) fetal death, early neonatal death of the newborn (n=61) and favourable perinatal outcome (n=50) was conducted. There was used the Bayes algorhythm with Wald's consecutive analysis in the modification of Genkin-Gubler to determine prognostic criteria. The comparative estimation of the efficacy of the proposed prognostic method and traditional method of determining perinatal risk was performed retrospectively in patients with perinatal losses (n=102) and favourable perinatal outcome (n=100). ROC analysis was performed.
Results. There were identified 42 risk factors divided into three groups: universal for all types of perinatal losses, common for two of them and specific for each of them (antepartum and intrapartum fetal death, early neonatal death of a newborn). There was determined the prognostic influence of factors in their presence and absence. It was found that universal and common risk factors had different prognostic influence for each type of perinatal losses. There was presented the method for differential predicting of perinatal losses. The sensitivity of the new and traditional prognostic methods was 95.1% and 69.6%, specificity was 80% and 53%, and the accuracy of predicting of unfavourable outcome was 87.6% and 61.4% respectively.
Conclusion. The investigation permitted to propose the new approach to estimation of perinatal risk, based on differential predicting of perinatal losses being is more effective than traditional method in predicting adverse perinatal outcomes.
CIRCULATING BRANCHED CHAIN AMINO ACIDS IN PATIENTS WITH CHRONIC HEART FAILURE AND TYPE 2 DIABETES MELLITUS
Authors: M.V. Kozhevnikova , V.Yu. Zektser , M.F. Petrukhnova , A.V. Krivova , S.A. Appolonova
Published: May 2024

The importance of the problem of chronic heart failure (CHF) is hard to overestimate: this syndrome is diagnosed in millions of patients around the world and its prevalence continues to grow. The proportion of patients suffering from carbohydrate metabolism disorders (CMD) is also steadily increasing. The close connection between carbohydrate metabolism disorders and the progression of CHF allowed such patients to be classified into a separate phenotype cluster - the “metabolic phenotype of CHF”. The pathophysiology of the “metabolic phenotype of CHF” is based on significant metabolic disorders, which determines the characteristic features of the metabolome of this cohort of patients. Therefore, the purpose of this work is to compare and evaluate the relationship between metabolites that occupy one of the most important places in the metabolic processes of the body - the levels of branched chain amino acids (BCAA) and the phenotypic characteristics of patients with CHF. The study included 218 patients: 133 patients of the main group suffering from CHF and having CMD; comparison group - 85 patients with CHF without CMD. The groups were comparable by gender (p=0,324) and age (p=0,936). The levels of BCAAs - leucine, isoleucine, valine - in the blood plasma of patients were assessed by high-performance liquid chromatography combined with mass spectrometry (HPLC-MS). Based on the results of the analysis, the following data were obtained: plasma levels of valine and leucine in patients with CHF and CMD were higher (p=0,022 and p<0,001, respectively) than in patients with CHF and normal carbohydrate metabolism. A direct relationship between the level of leucine + isoleucine and the concentration of glucose (r=0,3, p<0,001) and an inverse relationship between the plasma concentration of valine and the level of N-terminal propeptide of natriuretic hormone (NTproBNP) (r=-0,388, p<0,001) were found. It has been established that a high level of tissue insulin resistance in patients is associated with increased concentrations of BCAA. The results indicate the important role of BCAA in the pathogenesis of the “metabolic phenotype of CHF,” which requires further research in this direction.
APPROACHES TO MOTIVATING HEALTHY LIFESTYLE AND PREVENTIVE HEALTH PROMOTION MEASURES FOR MEDICAL UNIVERSITY STUDENTS
Authors: D.S. Yakushin , I.M. Arsanukaev , I.I. Yakushina
Published: May 2024

The priority direction of educational policy within the framework of the Priority 2030 academic strategic leadership program is to provide the country's healthcare with qualified and motivated medical personnel, in connection with which the requirements for clinical knowledge and skills, as well as for the skills of a modern doctor, are growing. Research, innovation and project activities become mandatory elements of educational programs, which are implemented through an individual educational trajectory to train specialists who meet a high standard of competencies. One of the directions of the individual educational trajectory is the creation of additional educational programs that expand the opportunities for students to obtain additional competencies. Purpose. On the basis of a sociological survey, to study students' satisfaction with the additional educational program aimed at the formation of professional competencies for training doctors to perform new labor functions in the formation of preventive programs, maintaining a healthy lifestyle and giving up bad habits. Materials and methods. The study includes the development of an additional professional program "Strengthening Public Health" using digital technologies in the field of preserving and strengthening public health, for the training of health professionals. Based on the results of the course of the additional professional program, a sociological survey was conducted in an online format through the Google Forms resource. A link to the survey was sent via email and WhatsApp messenger. Results. The data obtained in the course of the study allow us to see the problem of motivation of students who adhere or do not adhere to a healthy lifestyle and to develop measures aimed at attracting medical university students to physical education, sports and the formation of a healthy lifestyle. Conclusion. The formation of motivation for a healthy lifestyle among students of medical universities is one of the most significant areas of professional training of medical specialists.
ANALYSIS OF THE QUALITY OF MEDICAL DOCUMENTATION WHEN EVALUATING THE ACTIVITIES OF A DENTAL CLINIC
Authors: V.A. Zheleznyak , E.G. Borisova , L.P. Polevaya , M.V. Zhmud
Published: May 2024

One of the criteria for assessing the quality of medical care is the complete maintenance of medical records. Defects in the preparation of medical documents lead to serious errors, such as incorrect diagnosis, unreasonable choice of diagnostic methods and treatment. To clarify the causes of their occurrence and adverse consequences, the study and analysis of medical records in dental organizations is of no small importance. Properly completed medical documentation serves as the basis for conducting forensic investigations within the framework of a criminal case in case of defects in the provision of medical dental care. The outpatient card of a dental patient is the object of quality control of medical care in dental organizations in the event of conflict situations. Purpose of the study: To analyze the quality control and safety of medical activities and the examination of the quality of medical dental care carried out in the dental clinic of the Military Medical Academy named after. CM. Kirov. Material and methods. During the study, analytical and statistical methods were used. The collection of primary information was carried out on the basis of data from primary medical documentation - 1067 outpatient records of dental patients. Results and condemnation. A statistically significant influence of a doctor’s work experience on the completeness of providing information about patients’ complaints was revealed. Doctors with less experience provide more complete descriptions of patient complaints. Among all complaints, aesthetic ones were most often described; complaints of a morphological and functional nature were noted quite rarely. In the cards of form No. 043/u, in 46.67% there was no information about the bite, the hygiene index was not determined, treatment plans and visit diaries were not filled out correctly. Conclusions. Internal quality assessment helps to detect defects in filling out dental patient outpatient records. The importance of adequate medical record keeping is beyond doubt; the form of the medical record must meet the needs of dentists and contain information that complies with the legal and regulatory framework.
ETHICS OF PROFESSIONAL COMMUNICATION IN A DENTIST'S PRACTICE AND FORMATION OF COMMUNICATIVE COMPETENCIES
Authors: Yu.G. Fatayeva , T.K. Fomina , T.F. Danilina , E.G. Dorozhkina , Yu.M. Fedotova , R.K. Agarval
Published: May 2024

The article discusses the formation of professional communication skills among dentists. Providing medical, especially dental, care is associated with a high level of emotional stress for patients. Fears and anxiety about medical interventions often hinder patients from seeking care, thereby reducing the overall dental health of the population. Psychological and emotional comfort during patient visits often plays a crucial role in choosing a healthcare provider and facility. Furthermore, strong communication skills significantly increase patient compliance and improve the quality of medical care provided. Based on literary data, the article examines the problematic aspects of communication between healthcare providers and patients and analyzes the structure of effective professional communication aimed at ensuring comfortable dental treatment.
THE RESULTS OF DETERMINING THE PH OF GINGIVAL FLUID IN PATIENTS WITH NON-REMOVABLE DENTURES MADE BY TRADITIONAL AND DIGITAL METHODS
Authors: E.N. ZHulev , YU.A. Vokulova , N.A. YAnova , M.L. Zhdanova , S.E. Zhdanov , I.V. Velmakina , P.V. Goldobina , S.O. Isanina
Published: May 2024

Relevance. Non-removable dentures have an effect on the marginal periodontal of the supporting teeth. An objective criterion for evaluating the periodontal reaction is the hydrogen index of the secreted gingival fluid as the physiological environment of the body, the transudate of blood serum filling the gingival sulcus. The aim of the study was to determine the effect of non–removable prostheses made by traditional and digital methods on the condition of periodontal tissues by measuring the pH of gingival fluid. Materials and methods. To determine the pH of the gingival fluid, special strips of universal indicator paper were used, which allow measuring the pH of the biological fluid in the range from 3.0 to 7.5 units with a minimum step of 0,3. Results. Digital and traditional methods of manufacturing non-removable prostheses are statistically significantly distinguishable with a significance level of p < 0,025 by the pH value of the secreted gingival fluid. Thus, the hydrogen index of gingival fluid in patients with prosthetics using traditional technologies was shifted to a more acidic environment (the median samples differ by 15,4%). Our study made it possible to establish that the hydrogen index of gingival fluid in supporting teeth covered with non-removable dentures made by the digital method is closer to the boundary values of the norm, which indicates their weakly pronounced effect on the condition of the marginal periodontium, due primarily to the smaller thickness of the edge of the artificial crown, which does not have a repelling effect on the gingival margin, unlike from traditional designs with a thicker edge, secondly, the anatomical shape of the prosthesis, which differs little from a natural tooth, and thirdly, significantly less influence of the microbial landscape with a more precise fit of the edge of the artificial crowns to the posterior ledge.
SATISFACTION OF PARENTS OF CHILDREN WITH AUTISM SPECTRUM DISORDERS WITH DENTAL CARE ASSOCIATED WITH A MOBILE APP FOR SENSORY DEPRIVATION IN NEURODIVERSE PATIENTS
Authors: A.S. Dontsova , O.V. Gulenko
Published: May 2024

Patients with autism spectrum disorders pose a challenge to the dentist in terms of implement-ing preventive and treatment measures. This is due to the hypersensitivity of these patients to unavoidable dental stimuli and communication disorders. Previously, we developed a new method of mitigating dental stimuli for neurodiverse patients, realized in a mobile application. The aim of the study was to evaluate parental satisfaction with dental care against the back-ground of using a mobile application for sensory deprivation of children with autism. The study included 168 families with neurodiverse children who worked with the mobile application for 1 year. As a subjective criterion for evaluating the effectiveness of the mobile application, the opinion of the direct user (families - study participants) was analyzed, represented by a wide range of parametrics in terms of the multidimensional concept of "satisfaction" of expectations from the use of technology. The Customer Satisfaction Index was used to measure satisfaction with the interaction with the application during one year. The dynamics of the final satisfaction index after 1 and 12 months of the study (70.75% and 84.9%, respectively) indicates a positive subjective evaluation of both the process and the result of dental treatment of neurodiverse children using the mobile application.
STUDYING THE INFLUENCE OF ORTHOPEDIC PRODUCTS ON THE TURNOVER OF PHARMACY ORGANIZATIONS
Authors: E.E. Beykhchan , E.B. Nikiforova , R.A. Kukudzhanova , E.S. Krylova
Published: May 2024

Proper pharmaceutical care to the population is the most important task of our state. At the same time, the main role in resolving this issue belongs to retail pharmacy organizations, ensuring the availability of medicines and other pharmaceutical products for consumers. However, along with the need to provide timely and high-quality pharmaceutical services, retail pharmacy organizations are currently faced with a number of serious economic problems, among which the most pressing is the search for ways to increase competitiveness. As practice shows, one of the ways to solve this problem is to expand the functionality and range of pharmacy organizations, which, in particular, implies the creation of new and/or development of departments within them. One of the promising departments of a modern pharmacy organization is the orthopedic department. The market for orthopedic products has a noticeable and steady upward trend; the number of actual and potential consumers of these products, as well as the volume of their sales, increases every year. Orthopedic products for people with diseases of the musculoskeletal system are in particular demand, and demand is also growing among the group of consumers purchasing these products for sports and for the purpose of disease prevention. At the same time, an important issue is the organization of rational placement and comprehensive information to potential consumers about the properties, advantages and necessity of such goods. Integrated sales of medicines, other pharmaceutical products and orthopedic products can create an additional competitive advantage for a pharmacy organization in comparison with others and improve the economic and financial performance of the retail chain. The purpose of this study was to study the influence of orthopedic products on the turnover indicators of a pharmacy organization and to study the approaches used in practice for their placement in the sales area of a pharmacy.
As a result of the research, comparative data on the influence of orthopedic products on the turnover indicators of a pharmacy organization were obtained and the approaches used in practice to their placement in the sales area of pharmacy organizations were studied. It has been established that orthopedic products occupy a significant portion of sales in the total turnover of pharmacy organizations. At the same time, the best economic indicators in this regard were demonstrated by a pharmacy that has a separate orthopedic department, which allows us to consider it expedient to create specialized units in this area in a pharmacy organization.
INTRAABDOMINAL ANEURYSM OF THE UMBILICAL VEIN OF THE FETUS. (A RARE CLINICAL CASE)
Authors: P.H. Gadzhieva , L.V. Dikareva , K.P. Vorontseva
Published: May 2024

The umbilical cord is an extension of the fetal cardiovascular system. According to all available scientific data, umbilical cord abnormalities play an important and often decisive role in the development of complications during pregnancy and childbirth, including perinatal mortality. Thus, umbilical cord abnormalities include skinny umbilical cord, umbilical cord presentation, absolutely short umbilical cord, sheath attachment of the umbilical cord, presentation of umbilical cord vessels, hypoisvite and hyperisvite umbilical cord, single umbilical artery, persistence of the right umbilical vein, vein aneurysm and umbilical cord hematoma. There are several variants of localization of this vascular anomaly: in the area of attachment to the placenta, in the free part, in the area of the umbilical ring and in the intraabdominal (intrahepatic) part. There are no clinical recommendations for the management of pregnancy with an umbilical vein aneurysm. When detecting umbilical cord abnormalities, it is necessary to monitor the dynamics of changes in the size of the aneurysm with an assessment of the fetal condition. The article describes a clinical case of intraabdominal fetal umbilical vein aneurysm, which is extremely rare and accounts for less than 1% of all umbilical cord abnormalities. The patient's reproductive and genetic history is not burdened. The somatic history was aggravated by neurodegenerative diseases of the spine. The pregnancy proceeded against the background of repeated threats of termination of pregnancy and anemia.
INFLUENCE OF HYPOTENSIVE DRUGS IN THE POSTOPERATIVE PERIOD IN PATIENTS WITH PSEUDOEXFOLIATIVE SYNDROME DUE TO COMPLICATED CATARACTS
Authors: M.A. Frolov , B.B. Bekmirova
Published: May 2024

In modern surgery of complicated cataracts, an important factor is the preservation of visual functions with minimal costs. The surgeon’s experience and modern technology, which makes it possible to identify hidden symptoms of certain pathologies at the diagnostic stage, allows for a favorable completion of surgery with minimal intraoperative complications. This article shows the approach and observations of patients at risk of increasing eye pressure in the postoperative period due to the anatomical structures of the eye (in these cases, patients with open-angle glaucoma) to antihypertensive drugs. 131 patients (134 eyes) with various signs of pseudoexfoliation syndrome participated in the observation. Before planned surgery for complicated cataracts, all patients underwent ophthalmological diagnostics, medical history, and laboratory tests according to generally accepted methods. All operations were performed by the same surgeon. Cataract surgery was performed according to the standard technique (Phaco + intraocular lens) through a 2.2 mm incision, two 1.2 mm paracentesis, but for some patients other components of surgical interventions were added. In the observation groups, for better fixation and a lower percentage of complications in long-term follow-up periods, RPR, T-19, Myol were implanted in 27.7%. A large percentage of 34% were implanted with the HO Acrylic IOL model lens, which requires a 2.2 mm corneal incision. In observation groups 2 and 3, 32.5 and 31.8% preferred lenses to the Acrysoft IQ model. And in 32.5% and 13.6%, respectively, the AFY model. The choice of the method of surgical intervention, as well as the model of intraocular lenses, made it possible to predict the long-term postoperative period with less toxicity for the patient’s condition. No intraoperative complications were observed; the administration of antihypertensive drops, both in combination and in monotherapy in the early stages of the postoperative period, allowed maintaining eye pressure within normal limits in all observation groups.
COMPARATIVE ANALYSIS OF TREATMENT RESULTS OF OSTEOCHONDRAL DEFECTS OF THE ARTICULAR SURFACE OF THE KNEE JOINT ASSOCIATED WITH DAMAGE TO THE ANTERIOR CRUCIATE LIGAMENT
Authors: G.P. Kotelnikov , Y.V. Lartcev , D.S. Kudashev , D.A. Dolgushkin , S.D. Zuev-Ratnikov , N.D. Shcherbatov , V.G. Asatryan , A.A. Knyazev
Published: May 2024

Purpose of work: to perform a comparative analysis of the results of treatment of patients with osteochondral defects of the articular surface associated with damage of the anterior cruciate ligament of the knee joint. Materials and Methods. Between 2015 and 2023 inclusive, 72 patients with anterior cruciate ligament injury accompanied by osteochondral defects of femoral condyles were treated. All patients were randomly divided into three groups: the first group - simultaneous ACL reconstruction and abrasive chondroplasty (ACh-ACL group) (n=24); the second group - ACL reconstruction and microfracturing (MF-ACL group) (n=24); the third group - ACL reconstruction and mosaic autochondroplasty (OAT-ACL group) (n=24). For the purpose of independent evaluation, a control group - anterior cruciate ligament reconstruction with intact articular cartilage (IAC-ACL group) (n=24) was introduced for comparison. Results and Discussion. Having analyzed the results of IKDC-2000 and Lysholm + Tegner questionnaires at 3, 6 and 12 months after the operation we noted the greatest positive dynamics in the early postoperative period (3 months) in all groups. From 6 to 12 months the dynamics changed its tendency and more pronouncedly passed into a "plateau" in groups 1 and 2, which was clinically determined by the restoration of passive movements with insufficient volume of active flexion-extension movements in the knee joint, as well as by the persistence of pain syndrome during loading. Conclusions. Simultaneous reconstruction of osteochondral lesions of the articular surface of the knee joint and reconstruction of the anterior cruciate ligament is the basis for full restoration of the function and bearing capacity of the knee joint. In this case, the use of organ-reconstructive methods of surgical intervention (bone-cartilage autochondroplasty and anterior cruciate ligament reconstruction (OAT-ACL)) allows achieving better clinical results compared to "mesenchymal stimulation" of the defect area, showing full functional recovery of the knee joint.
Using Digital Technologies in Teaching and Learning of Literature in ESL Classrooms: A Systematic Literature Review
Authors: Shamshul Irdina Shamimi Mohamad , Ismail Hanita Hanim , Nordin Norazah Mohd
Published: May 2024

The uses of digital technology in the teaching and learning of literature in ESL classrooms has been accredited as following the global breakthrough of digitalisation. However, the limitations of digital tools, readiness, and the potential misuse of the technology, in incorporating digital technology in the literature of ESL classrooms, might become challenging. This systematic review analyses the possibilities, challenges and suggestions linked to the incorporation of digital technologies in the teaching of literature as part of ESL classrooms. To facilitate the shift to online learning while preserving consistency in the literature instruction, the review examines past discussions on the role of technological resources during the pandemic and how literary instructions in ESL classrooms are impacted by the digital age. This review offers a thorough overview of the state of digital technology in literary instruction in ESL classrooms by combining the findings and perspectives of the previous research. Using the PRISMA methodology, this review examines the use of digital technology in the teaching of literature in ESL classrooms. A total of 10 papers were chosen from 100 as part of the initial consideration; the studies were conducted between 2016 and 2023, considering both the inclusion and exclusion criteria. Several databases, such as ScienceDirect, Google Scholar and Web of Science, were used. The common attributes of the study findings highlight the significance of adopting a flexible strategy for integrating technology, recognising the challenges and seizing the opportunities presented for the advantage of teachers. Thus, it is empirical and necessary to assist teachers and relevant stakeholders in navigating the constantly changing landscape of literature instruction.
An Investigation into whether Applying Augmented Reality (AR) in Teaching Chemistry Enhances Chemical Cognitive Ability
Authors: Hoai Vu Thi Thu , Son Pham Ngoc , An Dang Thi Thuan , Anh Nguyen Viet
Published: May 2024

Chemical cognitive ability is a fundamental aspect of effective chemistry education, facilitating students’ understanding of essential concepts such as substance structure, chemical transformations, and atomic bonding processes. Augmented reality (AR) technology has emerged as a promising tool in science education, offering immersive learning experiences that enhance students’ comprehension of chemical phenomena. This study explored the utilization of AR applications, specifically QuimiAR, in the designing of six simulation videos focusing on chemical bonding processes. These videos were integrated into a teaching method centered around the topic “Chemical Bonding” and implemented in a secondary school classroom in Hanoi, Vietnam, comprising 32 students. Following the AR-enhanced teaching session, students’ chemistry cognitive ability was evaluated using three methods: standardized tests assessing five criteria of chemistry cognitive ability according to the Vietnamese educational curriculum; surveys gauging students’ interest and knowledge acquisition using AR; and in?depth interviews. The results indicate that AR usage significantly increased students’ engagement in learning, enhanced their understanding of substance composition and chemical bonding processes, and improved their ability to apply knowledge to solve learning challenges. This research provides practical guidance for educators in leveraging the advantages of QuimiAR software to design simulations focusing on chemical bonding, thereby fostering students’ cognitive ability in chemistry. By expanding the use of AR technology to create various chemical simulations, teachers can cultivate students’ cognitive abilities in chemistry, promoting active learning and facilitating academic success.
A VR-based Industrial Robot Platform for Interactive Teaching Specialized Courses of Mechatronic Engineering
Authors: Le Huy Tung , Dang Thai-Viet , Nguyen Thi-Thanh
Published: May 2024

The primary objective of Industry 4.0 is to establish seamless connections between the physical and digital domains. Virtual Reality technology is widely acknowledged as a revolutionary advancement that offers significant technical assistance to many different fields including industry, agriculture and individuals. Since its inception, VR-based education has not gone out of that trend. The paper outlines a methodology for developing virtual interactive applications for the purpose of teaching Mechatronics. Unity software is utilized for creating a three-dimensional virtual robot and its corresponding environment. Subsequently, a user-friendly interface for controlling a robot is constructed. Finally, a lesson plan was developed for the virtual interactive teaching approach in the industrial robot course for the undergraduate Mechatronics Engineering program. The integration of a quantitative evaluation approach, along with the subsequent self-assessment conducted by students upon completion of the module, has unequivocally shown enhancements and efficacy across several competencies with increases ranging from 85 to 92%. The utilization of virtual reality and interactive learning within virtual environments, together with the guidance of instructors, has significantly improved the learning experience and problem-solving abilities of engineering and technology students, enabling them to fulfill the required performance criteria.
Mathematical Proficiency, Scientific Reasoning, Metacognitive Skills, and Performance of Learners in Physics: A Mathematical Model
Authors: Pasigon Christzon Pagdawan
Published: May 2024

This study aims to explore the mathematical proficiency, scientific reasoning, and metacognitive skills that contribute to the student’s academic performance in Physics. Data were gathered quantitatively by administering the Basic Skills Diagnostic Test, Lawson's Classroom Test of Scientific Reasoning, and Metacognitive Awareness Inventory to Grade 10 students in the selected high schools of District II of Ifugao Province from January to June 2023. Using the Raosoft calculator, 369 out of 405 students were randomly selected as participants. Relationships of the variables were analysed using Structural Equation Modelling (SEM) where the direct and indirect effect was shown. Based on the model, mathematics proficiency, scientific reasoning (Formal Operational, Late and Early Transitional reasoners), and metacognitive skills (declarative, debugging, and evaluation) had a direct effect on academic performance in Physics. The scientific reasoning skills – late transitional directly affect the metacognitive skills – procedural, conditional, planning, and information. Further, an indirect effect of mathematics proficiency on scientific reasoning and metacognitive skills, scientific reasoning to mathematics proficiency and metacognitive skills, and metacognitive skills on scientific reasoning and mathematics proficiency, toward academic performance was observed. Conclusively, a strong foundation in mathematical proficiency with the effective use of scientific reasoning and metacognitive skills were found to be key determinants of success in Physics. This suggests that educational institutions craft Physics curricula considering the development of students in mathematical proficiency, scientific reasoning skills, and metacognitive skills, while teachers develop activities that refine the direct and indirect effects of these variables to target a better academic performance in Physics.
Beyond the Dictionary: Redefining Translation Education with Artificial Intelligence-Assisted App Design and Training
Authors: Bakhov Ivan , Bilous Nataliya , Saiko Mykhailo , Isaienko Svitlana , Hurinchuk Svitlana , Nozhovnik Oleh
Published: May 2024

This study addresses researchers’ concerns about the effectiveness of integrating AI-assisted app design and training into university-level translation courses. It aims to explore how this integration influences students’ motivation, reflective practices, academic performance, and the quality of language translation. Employing a mixed-methods research approach with a two-group post-test-only design, the study uncovers the transformative influence of integrating an AI-based translation assistant. Purposive sampling techniques were utilised to conduct interventions and focus groups with students majoring in Philology enrolled in the 3 ECTS course in Industry-Specific Translation at Taras Shevchenko National University of Kyiv. The findings from the Independent Samples t-test revealed significant improvements in motivation, reflective practices, academic performance, and translation quality among students in the experimental group (EG) compared to the control group (CG). Thematic analysis using the Speak web-based tool indicated an overall positive sentiment (0.224), highlighting Positive and Very Positive sentiments. The Neutral category suggested a balanced perspective, while the combined Slightly Negative and Negative categories represented less favourable sentiment. This research contributes valuable insights to the discourse on AI in language education by addressing gaps in related literature. We suggest avenues for future research into linguistic nuances and contextual challenges, advocating ongoing exploration to maximise the benefits of these technological interventions. Ultimately, this study provides a comprehensive understanding of the impact of AI integration in language education and underscores the need for continued exploration and adaptation in this area.
Paraneoplastic opsoclonus-myoclonus syndrome as a rare presentation of parotid adenocarcinoma
Authors: Yılmaz Buket Özkara
Published: May 2024

Paraneoplastic Opsoclonus-Myoclonus Ataxia Syndrome (POMA) is a rare neurological condition that affects approximately 1 in 10,000,000 people annually. This syndrome is poorly understood and can lead to long-term cognitive, behavioral, and motor complications. Opsoclonus is characterized by involuntary, rapid, repetitive, multi-vectorial oscillations of the eyes occurring in all directions of gaze. It is accompanied by diffuse or focal body myoclonus and may or may not include ataxia and other cerebellar signs. POMA is typically a paraneoplastic syndrome associated with neuroblastoma in childhood and breast carcinoma or small-cell lung carcinoma in adults. Additionally, viral or toxic agents are known to play a role in its etiology, and the immune system is involved in the pathogenesis. We report a case of a 41-year-old man with anti-Ri antibody opsoclonus-myoclonus syndrome and parotid adenocarcinoma involvement. After diagnosing opsoclonus-myoclonus syndrome, the patient underwent multimodal immunotherapy treatment, resulting in partial remission of the neurological symptoms.
The characteristics of the hemostatic system in patients with external genital endometriosis
Authors: Baigalmaa B. , Bitsadze V. , Solopova A. , Blinov D. , Bykovshchenko G.
Published: May 2024

External genital endometriosis (EGE) is a common disease that substantially lowers quality of life in women. EGE is accompanied by chronic pelvic pain in 50% of cases. The role of the hemostatic system, proinflammatory factors, the complement system, and other biomarkers in the pathogenesis of EGE seems interesting. The literature describes an endometriosis-characteristic (local and systemic) condition of local and systemic hypercoagulation, activation of proinflammatory molecules, chemokines, and complement components. It is remarkable that after surgical removal of endometrioid foci, the biochemical and coagulation parameters return to normal. The objective of this review is to summarize the data on the diagnostic and prognostic significance of hemostatic factors, proinflammatory cytokines, cancer markers, the immunological and genetic panels within the framework of EGE
TREATMENT OF ARTERIAL HYPOTENSION
Authors: Amlaev K. , Znamenskaya I.
Published: May 2024

Treatment of arterial hypotension is a complex problem that requires correction of the hemodynamic parameters of the patient and, if possible, an impact on the cause of a decrease in blood pressure. It is necessary to pay attention to the correction of factors aggravating the course of hypotension. It is also important to use non-drug methods of correction of low blood pressure, such as wearing compression underwear, increasing fluid and salt intake, the use of physical maneuvers and exercises. Pharmacological therapy of hypotension includes the use of a number of drugs with different mechanisms of action, such as midodrine, fludcortisone, droxidopa, norepinephrine membrane transporter inhibitors. Special attention is paid to the treatment of orthostatic hypotension, postprandial hypotension.
Biphasic non-invasive lung ventilation in the neonatal intensive care unit: the choice of tactics for starting respiratory support in preterm infants
Authors: Zavyalov O. , Pasechnik I. , Ignatko I. , Babaev B. , Rybintseva K.
Published: May 2024

The article deals with modern clinical and pathogenetic features of the variants of the respiratory pattern of non-invasive lung ventilation with two phases of airway pressure in the neonatal intensive care unit. The epidemiology, pathogenesis and assessment of the severity of the clinical picture of the neonatal respiratory distress syndrome are presented. The anatomical and physiological features of cardiorespiratory adaptation and targeted indicators of complex monitoring of the vital functions of the body of premature babies during the initiation of the starting two-phase non-invasive ventilation of the lungs are discussed. Early predictors of failure and criteria for optimizing the clinical efficacy of initial biphasic non-invasive ventilation in children with extremely low birth weight are considered. The clinical and prognostic role and features of perinatal screening were assessed when choosing the tactics of starting respiratory support in premature infants in the neonatal intensive care unit.
AVASCULAR NECROSIS AS A MANIFESTATION OF POST-COVID SYNDROME IN ROUTINE PRACTICE OF RHEUMATOLOGIST
Authors: Bazina I. , Krechikova D. , Kozyrev O. , Pavlova M. , Loginova I. , Kononova V. , Yakub L.
Published: May 2024

Avascular necrosis as a part of post-COVID syndrome requires increased attention of physicians due to significant misfunction of musculoskeletal system, increased disability, and frequently requires surgical intervention. It is known that hypercoagulation, thrombosis as well as systemic corticosteroid therapy during severe coronavirus infection play an important role in the development of avascular necrosis. A case report of progressive avascular necrosis in multiple loci accompanied by polyarthritis in a young man developed after severe COVID-19 is reported below
PRIMARY CEPHALGIA IN ADOLESCENTS WITH DISADAPTIVE ONLINE BEHAVIOR. APPROACHES TO THE TREATMENT OF TENSION HEADACHE
Authors: Kostyuchenko Yu. , Potupchik T. , Evert L. , Shubina M. , Hertek B.
Published: May 2024

A review of data on the main types of primary headaches in adolescents – tension-type headache (THT) and migraine (Mi) – was carried out. Definitions and characteristics of these types of cephalgia are given. The results of our own study are included, which showed differences in the frequency of occurrence and clinical features of these types of pathology in adolescents of different age and sex groups, their association with the type of online behavior and their closer relationship with non-adaptive and pathological (Internet-dependent) behavior of adolescents. Of the 5,195 adolescents surveyed, 51.9% were characterized by adaptive online use (AIU), 40.6% non-adaptive (NIU) and 7.5% pathological (РIU). The authors come to the conclusion that it is necessary to analyze the characteristics of adolescents using the Internet for early diagnosis and prevention of primary cephalalgia associated with maladaptive types of online behavior (NIU and РIU).
A change in the gut microbiota composition in patients with chronic heart failure and small bacterial overgrowth syndrome
Authors: Fadeeva M. , Zolnikova O. , Skhirtladze M. , Ivashkin V.
Published: May 2024

A change in the gut microbiota composition is a risk factor for the development and progression of a number of socially significant diseases. Thus, the prevalence of small bacterial overgrowth syndrome (SBOS) in patients with chronic heart failure CHF) is 38.2–42.0%, as shown by different data, which greatly exceeds that among the persons without CHF. SBOS in CHF is associated with the higher risk of long-term complications (hospitalization and death).
Objective. To study the qualitative changes in the large bowel gut microbiota in patients with CHF and SBOS.
Subjects and methods. The investigation enrolled 60 patients with CHF and a left ventricular ejection fraction of <50%, as evidenced by echocardiography (after Simpton), who had undergone lactulose hydrogen breath test for the diagnosis of SBOS. According to the test results, the patients were divided into 2 groups; 1) 25 patients with SBOSs; 2) 25 patients without SBOS. In both groups, sequencing of 165 ribosomal RNA was used to study gut microbiota in the fecal samples.
Results. Group 1 displayed a decrease in the Shannon index when calculated by bacterial types as compared with that in Group 2 (0.61 [0.49; 0.72] and 0.75 [0.58; 0.86], respectively; p=0.03). Group 1 also exhibited lower levels of the representatives of the Verrucomicrobia type as compared with Group 2 (0.21 [0.00; 4.03] and 2.61 [0.95; 8.02]%, respectively; p=0.05), in particular the Verrucomicrobiaceae family (0.21 [0.00; 4.03] and 2.61 [0.50; 8.42]%, respectively; p=0.05). The decreased level of the representatives of the Verrucomicrobiaceae family in patients with SBOS (Group 1) was due to the lower levels of the representatives of the Akkermansia genus (p=0.05), the only identified representative of which in this study was Akkermansia muciniphila; there were also decreased levels of the representatives of the Desulfovibrio genus (p=0.01), an increase in the representatives of the Dorea genus (p=0.005), as well as those presented in a small number of patients of Papillibacter (p = 0.02), Coprobacillus (p=0.02), Oribacterium (p=0,02), Clostridium cluster XVIII (p=0.05), Slackia genera (p=0.01). In addition, there were lower levels of the representatives of the the Dorea genus (p=0.005), as well as those presented in a small number of patients of Papillibacter (p = .0.02), Coprobacillus (p=0.02), Oribacterium (p=0,02), Clostridium cluster XVIII (p=0.05), Slackia genera (p=0.01).
A clinical case of late manifestation of celiac disease concurrent with another autoimmune disease
Authors: Grinevich V. , Kravchuk Yu. , Ivanyuk E. , Seliverstov P. , Yarovenko I. , Karagodin I. , Borisova A.
Published: May 2024

Celiac disease is a genetically determined disease with its onset in childhood. In November 2021, a 51-year-old female patient was admitted to the Gastroenterology Department with complaints with diarrhea 5 times daily and severe protein-energy malnutrition by the type of senile kwashiorkor. Analysis of her history indicated that in March 2021, the patient took amoxicilline 500 mg twice daily, as prescribed by the local therapist, for 2 weeks, whereupon she noted the appearance of diarrhea that lasted for a month. Moreover, antibiotic-associated diarrhea was ruled out. A celiac-disease-specific histological pattern of the small bowel mucosa was revealed (the ratio of villus height to crypt depth was 1:1), as well as the titer of antibodies to recombinant tissue transglutaminase-2 IgA class >210 U/ml. This could establish a diagnosis of symptomatic celiac disease. During the gluten-free diet, the stool returned to normal; the body weight gradually began to increase. The persistent severe condition in the patient, hypokalemia, skin bronze hue, low aldosterone levels could diagnose primary hypoaldosteronism. Liver biopsy could diagnose small duct primary sclerosing cholangitis. Thus, it is important to note that the onset of celiac disease may occur may occur in people over 50 years of age; whereas primary hypoaldosteronism and primary sclerosing cholangitis may be associated with celiac disease and have a common autoimmune origin.
A case of surgical treatment for gastrointestinal tract disease in myelomic disease
Authors: Sadkeev A.
Published: May 2024

Multiple myeloma can be accompanied by characteristic changes in the gastrointestinal tract (GIT). It is important to examine all GIT sections. Surgical treatment should be strictly prescribed as clinically indicated and be taken into account the patients’ immunodeficiency status.