bluuebunny/crossref_metadata_2025 huggingface dataset:
The problem of the accuracy of the tsunami activity parameters
Authors:   Institute of Marine Geology and Geophysics of the Far Eastern Branch of RAS, Kaistrenko V.M.
Published: June 2023

The subject of the article is the theoretical development of the probabilistic model for a Poisson-type tsunami sequence that is consistent with data on the manifestations of historical events, in order to obtain estimates of the accuracy of the tsunami activity parameters. An example of a tsunami recurrence function, which is the most important quantitative characteristic of tsunami activity for the Port of Malokurilskoye, one of the places in the South Kuril Islands region with the most reliable tsunami height dataset, was created on the basis of a theoretical essay. An explanation for the weak statistical stability of all large values of the tsunami heights, especially for the largest one in the series of observations, was given based on the probability density functions of the ranked tsunami heights. In particular, it means, for example, that the maximum tsunami height recorded at a certain location during a 30-year observation period should be correlated with a wide range of possible recurrence periods of about 10 to 100 years. Synthetic catalogs of the tsunami heights, built for the Port of Malokurilskoye, showed that the tsunami height datasets with a duration of at least 250 or 500 years without gaps are needed to obtain the tsunami activity parameters with an acceptable accuracy of 10 or 5 %. The most important results are the analytical equations for the variances of estimates of the tsunami activity parameters, which characterize the accuracy of these estimates, depending on a priori unknown values of the tsunami activity parameters and the amount of data used.
SPATIAL AND TEMPORAL FEATURES OF WATER CHEMISTRY CHANGES IN THE QUATERNARY UNCONFINED AQUIFERS OF THE DNIPRО RIVER BASIN
Authors: Lyuta N.G. , Sanina I.V.
Published: June 2023

The article deals with the chemical composition of uppermost aquifers water in the Dnipro River basin. Its study is necessary not only in connection with the implementation the requirements of the EU Water Framework Directive methodological documents in the groundwater monitoring, but primarily because of water supply from these aquifers to rural areas. Unconfined aquifers water is characterized by a complex and heterogeneous chemical composition due to natural and anthropogenic factors. Natural hydrochemical zoning is distinctly visible on the territory of the Dnipro basin. A number of chemical elements and compounds in the water are contained in concentrations exceeding the standards for drinking water established by the State sanitary norms and rules 2.2.4-171-10 “Hygienic requirements for drinking water intended for human consumption” in the natural state. In addition, unconfined aquifers are subject to significant anthropogenic impact, as they are unprotected from pollution. Comparison of the data on total dissolved solids (TDS) and anionic composition of groundwater obtained during hydrogeological surveys in the period 1965–1975 and 2009–2013 on three sheets of the hydrogeological map (scale 1:200,000) in different sub-basins of the Dnipro River showed the widespread deep changes in groundwater chemical composition. In addition to a significant anthropogenic pressure, groundwater is significantly affected by climatic factors. Over a forty-year period, TDS in the north of the Dnipro basin increased by 50 %, in the central and southern parts – twice, due to an increase in the content of sulfates and chlorides. Within the analyzed areas in the Middle and Lower Dnipro sub-basins, nitrate pollution of unconfined aquifers is almost widespread. Thus, in a large area, waters of these aquifers are unsuitable for drinking water supply due to the excessive content of chemical elements and compounds of natural and anthropogenic origin. Therefore, one of the priorities of the post-war reconstruction of Ukraine should be the transfer of the rural population to water supply from protected confined aquifers and the improvement of sanitary conditions in rural areas.
TYMKIVIA PRIMITIVA GEN. NOV. SP. NOV., A NEW TYPE OF FOSSILS FROM THE LATE EDIACARAN (VENDIAN) KANYLIVKA GROUP IN PODOLIA, UKRAINE
Authors: Martyshyn A.I.
Published: June 2023

A thick sequence of Ediacaran (Vendian) deposits is exposed in the southwestern part of Ukraine along the valley of the Dniester River and its left tributaries. The stratigraphy and lithology of these deposits have been studied in some detail, but information on the fossil record is still very scarce. The Kanilovka Group sedimentary sequence has the lowest level of exploration. Tymkivia primitiva gen. nov. sp. nov. is described from Late Ediacaran shallow-water marine rocks of the Podolia region. The fossils are casts of the inner surface and imprints on the surface of bacterial mats (“death masks”) of small, sedentary sac-like organisms. Numerous imprints on the surface of mudstone and siltstone slabs testify to the existence of mass settlements of these organisms in the Volyn-Podilsky sedimentary basin in the Late Ediacaran. Morphological details that could be interpreted as a mouth, anus, and internal organs are not found in the fossils. Tymkivia was found in association with bacterial mat remains and the carbonaceous compressions of Vendotaenia, Kanilovia, and the problematic rod-shaped Harlaniella. Tymkivia is interpreted as possible remains of benthic plants; it is morphologically similar to some modern green algae. The option of interpretation as a fossilized record of the polyp stage of Medusozoa (Cnidaria) cannot be ruled out either. The appearance and disappearance of these organisms are the benchmarks of the stage of sedimentation of the Kanylivka Group.
FINAL EDITION ON THE HISTORY OF MINERALOGY AND MINERALOGICAL KNOWLEDGE IN UKRAINE
Authors: Naumko I.M.
Published: June 2023

Information on the history of mineralogical research and knowledge in the independent Ukraine (since 1991) іs summarized in the book. The world-famous scientific schools formed in the second half of the 20th century (1940–1990): regional mineralogical, thermobarogeochemical, crystallochemical, mineral physics are characterized. The achievements of scientists in regional, systematic and genetic mineralogy, crystal chemistry and mineral physics, mineralogical crystallography, bio- and nano-mineralogy, experimental, space and applied mineralogy, museum work, etc. were analyzed. It is shown that after the crisis of the 1990s, traditional scientific directions are expanding and deepening, and new scientific directions are being initiated, in particular nanomineralogy and ecological mineralogy, the number of minerals discovered in the depths of Ukraine is growing rapidly, new periodical editions, textbooks and manuals are appearing, work is underway to create of the modern monographic summary – the Ukrainian mineralogical encyclopedia. The analysis of the obtained mineralogical and historical knowledge aims at new achievements in the field of mineralogy within the framework of the next major research path – «to develop all scientific directions of mineralogy, but with an emphasis on giving priority to regional mineralogical and applied works». The publication shows the ways of development and the fate of mineralogy in crisis conditions, especially at the modern stage in the complex geopolitical conditions of today, in particular during the war with an external aggressor, therefore, it is timely and necessary, both for specialists in the field of Earth sciences, first of all, for geologists and mineralogists – scientists, teachers, practitioners, and for those who are interested in the history of science.
Mixing Specific and More Universal Design Media to Deal with Multidisciplinarity
Authors: Vandenhende Karel
Published: June 2023

In this paper, we investigate which strategies designers use to be able to deal with multidisciplinarity in architecture, and by which media designers communicate in this changed conditions. From a literature review, we learn that designers have to use an unpredictable, often long and iterative process in which the cycle of concept, testing, evaluation and conclusion is repeated until a satisfactory solution has been formulated. This turns the design process in an almost endless sequence of models, drawings, texts, images, samples, mock-ups, renderings and other media. And at the same time, designers have to be able to check if all these different investigations match with each other. On the one hand, designers seem to use all kinds of different and distinct media and many different forms of representation to investigate the wide variety of constraints. And on the other, they synthesise all these investigations with diagrams and schemes that bring together all the separate design investigations, and make it possible to match the results from the distinct disciplines. In architecture today, designers seem to combine specific representations, or jargon, together with more universal standard media, at the same time integrating the peculiar and the general.
Assessing Governance Structures in State-owned Enterprises using Transaction Cost Economics’ Dimensionalisation
Authors: Adebayo Adeyemi
Published: June 2023

This paper illustrates how Transaction Cost Economics’ (TCE) dimensionalisation, a governance structure comparative analysis tool, may be used in assessing corporate governance structures. To illustrate, this paper assesses the governance structures of state-owned enterprises (SOEs) in South Africa and Singapore, two countries deploying different governance structures for organising SOEs. A proposition was developed in line with dimensionalisation to assess the organising models. The proposition is that SOEs organised using a bilateral governance structure are expected to perform better than those organised using a unified governance structure – since the attributes and characteristics of transactions/contracts are semi-strong in the bilateral structure, according to TCE. Findings appear to support the proposition, indicating that SOEs organised in a bilateral governance structure perform better relative to those that are organised under unified governance. Keywords: dimensionalisation, organising models, ownership models, state-owned enterprises, transaction cost economics (TCE)
The Role of Country-pair-related News Sentiment in Foreign Exchange
Authors: Unger Stephan
Published: June 2023

This article explores the relative, explanatory contribution of country-pair-related political and financial news to foreign exchange rates. Contributing political factors are measured through the sentiment scores of published news while contributing financial factors are measured through various economic indicators such as price and volume of USD and CNY oil futures, the Russian IMOEX Index, and corresponding interest differentials. The results show that news sentiment plays a minor role in exchange rate determination while other factors such as prices and traded volumes in oil future contracts and interest differentials are significant contributing factors to the exchange rate determination. Nevertheless, the quality and quantity of news coverage of geo-political or economic events seems to play an important role when it comes to the impact of news on exchange rates. Among the sentiment-analyzed currency pairs, EUR/USD exhibits by far the highest sensitivity to political and economic news, followed by EUR/RUB, RUB/CNY, EUR/CNY, USD/CNY, and USD/RUB. Keywords: foreign exchange, news sentiment analysis, text mining, geo-political sentiment JEL-Codes: F31, E71
Impacto potencial da COVID-19 no perfil de consumo de antibacterianos de reserva – AWaRe em unidade de terapia intensiva de um hospitalp úblico
Authors: SILVA Luana Kellen , MEDEIROS Amanda Fonseca , FIGUEIRÓ-SOUZA Ana Flávia , MARTINS Maria Auxiliadora , BERTOLLO Caryne Margotto
Published: June 2023

Objetivo: Avaliar a variação de consumo de antibacterianos (ATB), monitorados pela Agência Nacional de Vigilância Sanitária (Anvisa), componentes do grupo reserva de acordo com a classificação Acess, Watch, Reserve (AWaRe) da Organização Mundial da Saúde (OMS), em Unidade de Terapia Intensiva (UTI) de hospital público. Método: Estudo de utilização de medicamentos, do tipo quantitativo, com coleta retrospectiva dos dados, de novembro/2018 a outubro/2022. A Dose Diária Definida (DDD) por 1000 pacientes-dia foi utilizada na avaliação do consumo de daptomicina, linezolida parenteral, polimixinas B e E, tigeciclina e ceftazidima-avibactam. As DDDs foram calculadas utilizando-se a fórmula de DDD padrão da OMS. O período de análise foi dividido em três fases: pré-pandemia da COVID-19, fase aguda e pós-fase aguda da pandemia da COVID-19. Calculou-se a razão entre a soma das DDD mensais nos períodos avaliados. Resultados: Na UTI do hospital de estudo houve aumento de consumo de daptomicina e tigeciclina na fase aguda, e de todos os ATB no pós-fase-aguda em relação à fase pré-pandemia. No pós-fase aguda, o consumo de daptomicina, linezolida e polimixina B aumentou em relação à fase aguda. O consumo de polimixina B, polimixina E e tigeciclina nas fases pós-aguda e aguda foi influenciado, também, por instabilidade no mercado farmacêutico. A partir da fase aguda da pandemia, a lista institucional de ATB padronizados passou a incluir polimixina E e ceftazidima-avibactam. Conclusão: Identificou-se por meio desse estudo, variações no consumo de ATB do grupo reserve as quais podem ter sido influenciadas pela pandemia da COVID-19. Esses dados podem fundamentar aprimoramentos do PGA local, a fim de preservar a efetividade desses medicamentos, que devem ser utilizados como última alternativa terapêutica.
Potenciais interações medicamentosas em prescrição de pacientes internados com doenças respiratórias em hospital universitário durante inverno amazônico
Authors: PICANÇO Robert Candido , LIMA Vitor Souza , SANTOS Cintia Pessoa , SILVA Weilla Cordeiro , GOMES Bruno Quadro , MELO Ademar Soares , GRISÓLIA Alan Barroso
Published: June 2023

Objetivo: Identificar e descrever a prevalência potenciais interações medicamentosas (PIM) em pacientes internados com doenças respiratórias durante período de inverno amazônico, buscando também classificar PIM em função do risco e o manejo clínico. Métodos: Um estudo descritivo, tipo transversal, retrospectivo, com abordagem quantitativa de pacientes internado no hospital universitário durante inverno amazônico. Foram selecionados 40 pacientes e analisadas 120 prescrições, coletando dados como identificação do paciente, hipótese diagnóstico, medicamentos utilizados. A investigação de potenciais interações ocorreu no período de 24 horas, 7 dias e 14 dias. A identificação e as classificações quanto aos riscos das PIM formam realizadas pela plataforma de apoio LexicomP® via aplicativo UpToDate®. Foi feita estatística descritiva dos dados, os quais foram compilados em planilha do Microsoft Excel®. Resultados: Dos 40 pacientes, 55% eram homens, a média de idade foi de 46 ± 22 anos, o tempo  médio de internação foi de 41 ± 30 dias, a maioria dos pacientes apresentaram Tuberculose Pulmonar, Pneumonias não especificadas e Derrame Pleural. Nessa população, análise da classificação de risco das PIMs, mostrou um total de 989 interações medicamentosas, com aproximadamente 8 PIM/prescrição. Um predomínio de PIM com risco baixo (classe C e B). Entre os medicamentos envolvidos o omeprazol x dipirona, dipirona x captopril, sendo essas de risco B e C, respectivamente. Apesar da maioria das PIM serem baixo risco, também ocorreram interações de risco elevado risco, não recomendadas (Classe X), totalizando 51 interações, sendo a mais prevalente e omeprazol e rifampicina, a qual pode induzir desconfortos gastrointestinais, e seu manejo consiste na substituição do omeprazol pelo pantoprazol. Além desse, segunda interação de risco X com maior ocorrência foi escopolamina mais brometo de Ipratrópio, a qual poderia induzir efeitos anticolinérgicos nos pacientes. E também foi detectado a PIM entre Prometazina x Bromoprida com risco de síndrome neuroléptica maligna ou reações extrapiramidais, esses devem ser manejados de maneira individualizada. Conclusão: Identificou-se uma elevada ocorrência de PIM nas prescrições de pacientes com doenças respiratorias durante o período putativo inverno amazônico. Apesar de na sua maioria ser de baixo risco, as PIM classificadas como X se mostraram presentes e consequentemente demandando manejo clínico. Por outro lado, para avaliar suas repercussões clínicas, mais estudos metodologicamente diferentes são necessários. Ainda assim, o conhecimento das PIM podem ajudar a estabelecer estratégias terapêuticas adequadas nessa população.
A Brief Analysis on Adverse Side Effects of COVID-19 Vaccines
Authors: Johnson Danny , Smith Jane
Published: June 2023

A Brief Analysis on Adverse Side Effects of COVID-19 Vaccines
A Review of Recurrent Meningiomas with Prolonged Response to Cabozantinib, an Oral Multitarget Tyrosine Kinase Inhibitor
Authors: Moerane Teboho Alfred
Published: June 2023

Meningiomas are cerebral cancers that arise from abnormal cell development in the meninges and defensive layers covering the mind and spinal line. They can attack areas close to the cerebrum tissue and apply tension to neighboring designs, prompting different neurological side effects. Recent advances in atomic science and genomics have revealed insights into the fundamental subatomic adjustments and flagging pathways involved in the improvement of meningoma. Cabozantinib, a chemotherapeutic agent, has shown promising results in preclinical and clinical studies in various malignancies, including meningia. It inhibits angiogenesis, reduces cancer development, and prompts cell passage, providing areas of strength for clinical examination. Inhibition of VEGFR2 signaling has shown promise results in clinical trials in various cancer types, including a variety of cancers. This review summarizes the current knowledge on the pathophysiology and potential therapeutic effects of cabozanteb as a therapeutic agent for intracranial meninga.
CFD is differentially expressed in metastasis to the brain in breast cancer.
Authors: Mamoor Shahan
Published: June 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that complement factor D, encoded by CFD, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. CFD mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of CFD in primary tumors was correlated with patient recurrence-free survival. Modulation of CFD expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Metode Penyelesaian Hadis Mukhtalif
Authors: hudin Solah
Published: June 2023

Perbedaan dalam hadits mukhtalif sering kali menjadi masalah dalam pemahaman hadits, terutama bagi umat Muslim yang ingin mempelajari ajaran Islam secara lebih mendalam. Oleh karena itu, artikel ini bertujuan untuk membahas hadits mukhtalif. Dalam penelitian ini, penulis menggunakan metode kajian teoretis dengan menganalisis hadits dari segi sanad, matan, dan konteks sejarah. Sebagai sumber utama dalam mempelajari ajaran Islam, hadits seringkali menjadi subjek diskusi dan kajian. Namun, dalam pemahaman hadits, sering kali ditemukan perbedaan antara hadits mukhtalif yang menyebabkan kebingungan. Oleh karena itu, penelitian ini bertujuan untuk membahas tiga pasang hadits mukhtalif.
PENGARUH PENGGUNAAN BUKU ELEKTRONIK TERHADAP HASIL BELAJAR
Authors: Sanjaya Manal
Published: June 2023

Era digital, yang ditandai dengan munculnya internet dan teknologi informasi komputer, telah mengubah gaya hidup manusia secara signifikan. Salah satu perubahan yang cukup besar adalah transformasi buku cetak menjadi e-book melalui perpustakaan digital. E-book merupakan versi elektronik dari buku, yang memungkinkan informasi dalam bentuk digital seperti teks dan gambar.E-book memiliki sejumlah kelebihan, seperti kepraktisan dan portabilitas yang memungkinkan pembaca untuk membawa banyak e-book dalam perangkat elektronik mereka. Selain itu, e-book juga lebih ramah lingkungan karena tidak memerlukan penggunaan kertas dalam produksinya, serta memiliki daya tahan yang lebih lama dibandingkan buku cetak. Penggandaan e-book juga lebih mudah dan murah, serta distribusinya dapat dilakukan secara cepat melalui internet.Namun, e-book juga memiliki kekurangan, seperti ketergantungan pada daya baterai atau sumber listrik untuk membaca, serta rentan terhadap pembajakan yang dapat mengancam hak cipta. Selain itu, penggunaan layar perangkat elektronik dalam membaca e-book dapat menyebabkan gangguan pada penglihatan.Penggunaan e-book interaktif dalam pembelajaran memberikan kemudahan bagi siswa dalam belajar secara mandiri maupun di dalam kelas. Melalui komponen seperti gambar, audio, dan video pembelajaran, e-book interaktif mampu menarik perhatian siswa dan meningkatkan motivasi belajar serta prestasi akademik mereka.Dengan demikian, e-book interaktif memiliki potensi besar untuk meningkatkan keberhasilan belajar siswa dibandingkan dengan penggunaan buku teks konvensional. Dalam era yang semakin digital ini, pendidikan perlu terus beradaptasi dengan perkembangan teknologi untuk memberikan pengalaman belajar yang lebih efektif dan menarik.
A novel stochastic method to determine thermal diffusivity for a shallow vadose zone: the theoretical derivation and application adopting the spectral analysis of temperature
Authors: Shih David Ching-Fang
Published: June 2023

Spatial heterogeneity and temporal variability are typical features of the heat transfer properties, including thermal diffusivity, in the shallow vadose zone. Assessing the heat transfer property, particularly in the context of time-dependent observations, may pose challenges in achieving effective evaluation. This study aims to analyze the dominant frequency in the temporal evolution of temperature within a shallow unsaturated soil zone system. The thermal diffusivity of the zone profile can be determined by employing temperature auto and cross-spectral density in the frequency domain. The study presents a theoretical spectral representation of an analytical system that combines temperature and thermal diffusivity considering two boundary conditions: (1) temperature at the inlet and outlet and (2) temperature at the inlet while ensuring no heat flux at the outlet. Subsequently, an inverse method is employed to estimate the thermal diffusivity by utilizing observed in situ temperature spectra. By selecting the domain length, significant frequency component, and boundary types of the designed elements, the study assesses the uncertainty of the system by examining the cross-variation of thermal diffusivity at different target depths. The study also examines the validity of the derived thermal diffusivity values for the proposed soil layer. The innovative research demonstrates the feasibility and applicability of using stochastic time-frequency spectral analysis to accurately determine the thermal diffusivity in the soil-water layer of a shallow vadose zone.
Analyzing Potential Drug Interaction Profiling Approach: Covid-19 as Case Study
Authors: Jugoer Niloka , Shield Wofram
Published: June 2023

Analyzing Potential Drug Interaction Profiling Approach: Covid-19 as Case Study
Development of a method for the estimation of non-nutritive sweetener intake from beverages using daily dietary data (SWEET-EST)
Authors: Heggie Lisa , Conway Rana , Fildes Alison , Smith Andrea , Scott Corey , Boniface David , Llewellyn Clare
Published: June 2023

Background: The long-term health effects of non-nutritive sweetener (NNS) consumption remain uncertain, partially due to limited data on population-level intakes. Most food composition databases lack information on NNSs, and technical approaches to assess NNS content of products may be inaccessible for most researchers. Therefore, effective methods to quantify NNS content within products and estimate consumption are important for public health research. Objective: To develop a method for the estimation of NNS intake from beverages using daily dietary data. Design: SWEET-EST, a novel seven-step method for the estimation of NNS intake from beverages using daily dietary data was developed to be capable of estimating intake of different NNSs, in milligrams per day (mg/d). SWEET-EST aimed to provide flexibility to researchers, allowing adaption to different contexts and populations based on user needs, and data available to them. SWEET-EST was designed to use existing information from (i) food composition databases; (ii) contemporary ingredient lists of beverages; (iii) sweetness intensity ratings of comparable beverages; and (iv) concentration-response models relevant to specific NNSs. The method was applied to a UK paediatric dietary dataset collected via three-day diet diaries from children aged 21-months (n=2,592) with repeat measures at 7 years (n=592). Results: At 21-months, 37.0% of the sample were classified as consumers of any NNS; 46.1% were at 7 years of age. Beverages identified as sources of NNS were ‘fruit-flavoured concentrates’, ‘carbonated soft drinks’ and ‘fruit-juice based drinks’. Intake estimates (in mg/d) were obtained for aspartame, acesulfame-potassium (ace-K), saccharin and sucralose. Conclusions: SWEET-EST supports the estimation of NNS intake from beverages (in mg/d) in large population studies. This novel method opens new opportunities for the quantification of NNS intake from beverages in large population-based samples when research teams do not have access to quantitative information from ingredients lists or resources to perform additional analysis or assays.
Understanding the Chances of Opioid Leading to Death
Authors: Tahir Eman
Published: June 2023

Understanding the Chances of Opioid Leading to Death
Publishing Combined Web Tracking and Survey Data
Authors: Munzert Simon , Ramirez-Ruiz Sebastian , Watteler Oliver , Breuer Johannes , Batzdorfer Veronika , Eder Christina , Wiltshire Deborah A , Barberá Pablo , Guess Andrew Markus , Yang JungHwan
Published: June 2023

Combined survey and web tracking data have great potential for social-scientific research. They allow linking information on online behavior with data on reported offline behavior, opinions, and attitudes. At the same time, ethical, legal, and technical challenges make it difficult to disseminate linked web tracking data to the scientific community. This whitepaper aims to address these challenges by providing guidance for researchers and archivists, discussing legal, practical, and ethical aspects, disclosure risks, and establishing a framework for publishing web tracking data. Recommendations for best practices are also provided based on experiences from a research project funded by the German Consortium for the Social, Behavioural, Educational and Economic Sciences.
LMAN1L is differentially expressed in central nervous system metastasis.
Authors: Mamoor Shahan
Published: June 2023

Metastasis to the brain occurs in a significant fraction of patients with solid tumors including breast cancer and metastatic melanoma (1-3). We mined published RNA-sequencing and microarray data (4, 5), comparing primary and brain metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the CNS. We found that lectin, mannose binding 1-like, encoded by LMAN1L, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Study of microarray data (5) revealed conserved but modest differential expression of LMAN1L in CNS metastasis in patients with metastatic melanoma. LMAN1L mRNA was present at increased quantities in metastasis to the brain in humans with breast cancer. Expression of LMAN1L in primary tumors of the breast was correlated with patient distant metastasis-free survival. Modulation of LMAN1L expression may be relevant to the biology by which tumor cells metastasize to the brain in humans with solid tumors with propensity for the CNS including breast cancer and metastatic melanoma.
Dorsomedial prefrontal cortex (DMPFC) prioritizes social learning during rest
Authors: Jimenez Courtney A. , Meyer Meghan L
Published: June 2023

Sociality is a defining feature of the human experience: we rely on others to ensure survival and cooperate in complex social networks to thrive. Are there brain mechanisms that help ensure we quickly learn about our social world to optimally navigate it? We tested whether portions of the brain’s default network engage “by default” to quickly prioritize social learning during the memory consolidation process. To test this possibility, participants underwent functional magnetic resonance imaging (fMRI) while viewing scenes from the documentary film, Samsara. This film shows footage of real people and places from around the world. We normed the footage to select scenes that differed along the dimension of sociality, while matched on valence, arousal, interestingness, and familiarity. During fMRI, participants watched the “social” and “non-social” scenes, completed a rest scan, and a surprise recognition memory test. Participants showed superior social (vs. non-social) memory performance and the social memory advantage was associated with neural pattern reinstatement during rest in the dorsomedial prefrontal cortex (DMPFC), a key node of the default network. Moreover, it was during early rest that DMPFC social pattern reinstatement was greatest and predicted subsequent social memory performance most strongly, consistent with the “prioritization” account. Results simultaneously update 1) theories of memory consolidation, which have not addressed how social information may be prioritized in the learning process and 2) understanding of default network function, which remains to be fully characterized. More broadly, the results underscore the inherent human drive to understand our vastly social world.
Brain functional segregation, handedness and cognition in situs inversus totalis: a replication study
Authors: Gerrits Robin , Vingerhoets Guy
Published: June 2023

Situs inversus totalis (SIT) is a rare congenital anomaly in which the arrangement of the visceral organs is completely left-right mirrored. A previous study by our lab suggests that SIT (N = 15) pairs with more heterogeneous asymmetrical brain organization and increased left-handedness. In addition, visceral reversal paired with poorer cognitive performance, especially when hemisphere organization was atypical. The current study sought to replicate these findings in a larger sample. We scanned 23 volunteers with SIT as well as an equal number of controls with usual organ arrangement, and determined their hemisphere dominance for two left hemisphere functions (language and manual praxis) and two right hemisphere functions (spatial attention and face recognition). Effects of situs inversus etiology were explored by pooling data from the original cohort with the replication sample. Our results reveal the expected population dominance for each of the cognitive functions in SIT, albeit they were less pronounced – but not significantly so – compared to controls. Unusual patterns of hemispheric crowding and mirror-reversal of functional brain organization was observed more often in SIT (48%) than in the controls (30%), but this difference also did not reach statistical significance. However, left-handedness was found to be significantly more common in SIT (24%) than in the overall population (10.6%). Finally, cognitive ability was not associated with organ situs or hemisphere organization. Taken together, our data adds to the growing evidence that the determinants of visceral and neural asymmetries are largely independent from one another and that complete situs inversus does not co-occur with an obligatory transposition of the brain’s functional architecture. There nevertheless might be instances in which (genetic) factors simultaneously cause complete visceral reversal and atypical brain laterality, particularly in asyndromal cases of situs inversus.
A critical review of research on generational cohorts
Authors: Clements Andrew James
Published: June 2023

There are claims made by some researchers and consultancies – among others – that there are fundamental differences between generations (e.g. “Baby Boomers” and “Millennials”) in terms of, for example, personality and preferences, motivation, and work values. However, these claims are often presented with more confidence than is warranted, given that the evidence is mixed, and effect sizes often small. This chapter critically explores the evidence, but also questions the “reality” of generational categories often used (e.g. “Baby Boomers”). Key issues explored in this chapter include the implications of generational cut-off points, assumptions of experiences and characteristics that are both shared within and unique to particular generations, and the role played by, and impact of, stereotypes. It is argued that organisational policy should not be informed by claims made about generations, e.g. what members of a particular generation want. Practice should be informed by better quality bodies of evidence, e.g. relating to the design of work or the use of rewards. If generational research is to provide useful insights, different research approaches are necessary. This is a preprint of a book chapter in search of a permanent home. I welcome suggestions on potential homes for this chapter, as well as feedback on the chapter itself. Readers are welcome to cite this chapter in its present form.
Crises in times of crisis. Employment vulnerability and couple instability during the Covid-19 pandemic in five European countries
Authors: LUPPI FRANCESCA , Zanasi Francesca , Rosina Alessandro
Published: June 2023

Couple stability at younger ages is a precondition for family formation and childbearing. While there is evidence that the Covid-19 crisis, bringing about a major economic recession, has impacted on union formation in high income countries, micro-level studies on union dissolution are almost absent. Our explorative research provides descriptive evidence on how employment vulnerability (e.g., holding temporary occupations) is associated with different chances of (intending to) breaking up before the Covid-19 pandemic. The analyses have been conducted on survey data collected in April/May and October/November 2021, on quota samples of young individuals (aged 18 to 34) in Italy, France, Germany, Spain, and UK. We find that employment vulnerability spills over into separation plans in times of economic recession, and in European regions reporting poorly performing labour markets (e.g., in terms of women employment and youth unemployment). On the contrary, among men with less vulnerable employment conditions, couple stability is less negatively affected by the recession, while they report higher chances to revise their pre-pandemic intention to break-up because of non-economic reasons.
The Study on Genetic Variability and Heritability in F4 Population of Rain-fed Rice (Oryza sativa L.)
Authors: Ferdous Tasnia , Nur Iffat Jahan , Romel Monirul Haque , Bhuiyan Shahidur Rashid
Published: June 2023

Population establishment, selection, and evaluation are key components of plant breeding program. This study was designed to observe the genetic variability and the heritability of the selected yield component traits in F4 rice population. A field experiment was carried out with 16 F4 materials and 4 check varieties of Oryza sativa L. at Sher-e-Bangla Agricultural University, Dhaka to identify the suitable traits for the augmentation of rice yield. The F4 populations obtained from BR21×BR26, BR21× BRRI dhan28, BR 21× BRRI dhan29, BR24× BRRI dhan29, BR24× BRRI dhan36, BR26× BRRI dhan36 were utilized as breeding materials. Nine characters were considered i.e., days to 50% flowering, 80% maturity, plant height, tiller per panicle, panicle length(cm), filled grain per panicle, yield per plant(g), thousand-grain weight(g) and yield (t/ha). The selected genotypes were found significantly variable for all of the characters. The lowest days to maturity (92.00 days) were observed in G11 (BR21 × BRRI dhan29, F4, S7P2) following as G4 (BR21 × BRRI dhan29, F4, S1P2) (95.33 days) and G5 (BR21 ×BRRI dhan29, F4, S1P5) (96 days). The highest yield among F4 population was recorded in G6 (BR21 × BRRI dhan29, F4, S6P3) (6.08 t/ha) followed by G10 (BR21× BRRI dhan29, F4, S7P1) (5.30 t/ha) and G7 (BR21 × BRRI dhan29, F4, S6P8) (4.68ton/ha). All the traits showed remarkably higher phenotypic variances than the genotypic variances. Besides, all characters showed high heritability and higher PCV than the GCV. High heritability along with moderate to high genetic advance in percent mean is controlled by additive gene action which is better for selection. 
Int. J. Appl. Sci. Biotechnol. Vol 11(2): 99-105.
Screening of Anaerobic Germination Rice Genotypes in Nepal
Authors: Tripathi Santosh Raj , Dhakal Krishna Hari , Ghimire Surya Kanta , Dixit Salabh , Yadav Ram Baran , Subedi Sushil Raj
Published: June 2023

Poor germination has been the main obstacles to the widespread adoption of rainfed lowland rice production due to the saturated state of the soil, . In order to produce rice types appropriate for direct seeded culture, the current experiment was conducted to find rice with anaerobic germination tolerance. The screening techniques of the tray method were used to assess the anaerobic germination tolerance of 402 different rice genotypes. Under anaerobic conditions, the genotypes 10 genotypes namely, IR 129077:1-1-6-8-B, IR 129077:1-1-6-9-B, IR 129077:2-1-16-8-B, IR 129077:1-1-36-5-B, IR 129077:1-1-41-7-B, IR 129077:1-1-46-6-B, IR 129077:2-1-17-6-B, IR 129077:1-1-31-5-B, IR 129077:1-1-39-8-B, IR 129077:2-1-13-7-B, IR 129077:2-1-17-7-B and IR 129077:2-1-28-7-B recorded the highest germination percentages (> 80%). Under anaerobic germination, the recorded coleoptile length for all genotypes ranged from 0.50 to 10.6 cm. The best performing genotypes were chosen for genotyping using previously published SSR markers based on the screening results. On QTL analysis, anaerobic germination QTL (qAG) present on Chromosome number 11 and chromosome 12 for higher germination and QTL (qCL) on chromosome 12 for longer coleoptile. 
Int. J. Appl. Sci. Biotechnol. Vol 11(2): 78-84.
Comparison between Measurements of Clinical Attachment Level and Transgingival Probing with Alveolar Bone Crest Level in Chronic Periodontitis Patients
Authors: Sah Sunita , Shrestha Sajeev , Acharya Pujan , Adhikari Khushbu
Published: June 2023

Background: Periodontitis is an inflammatory disease of the supporting tissues of the teeth that leads to crucial changes in the bony architecture. Early detection is of great practical significance so that treatment may be administered before irreversible destruction could occur. Differences exist between different diagnostic methodology concerning the relationship between the measurements and the level of the lesion. The aim of this study was to assess relationship between clinical attachment level (CAL) and alveolar bone crest level (ABCL), reliability of transgingival bone probing level (TBL) for ABCL measurement, and clinical biologic width (CBW) measurement in chronic periodontitis patients.
Methods: An analytical cross-sectional study was conducted on 238 periodontal sites in 25 chronic periodontitis patients, aged 20–60 years who were planned for periodontal flap on residual pocket depth of 5-8mm after four weeks of non-surgical therapy. Stent was used for coronal fixed reference point. The relative attachment level (RAL), relative transgingival bone probing level (RTBL), relative alveolar bone crest level (RABCL), and CBW were measured at six sites per tooth excluding third molars. Descriptive and inferential statistical analysis was done. Probability of significance (p-value) was set at 5%.
Results: Overall RAL, RTBL and RABCL (mean ± SD) were 8.08 ± 1.23, 10.82 ± 1.1, and 11.15 ± 1.36 mm respectively. Overall CBW (mean ± SD) was 3.06 ± 0.634 mm.
Conclusions: There was a significant positive correlation of CAL and TBL with ABCL. Also, the CBW was greater than that of standard histologic BW.
Emergency Department Patient Satisfaction Survey in a Tertiary Care Hospital of Eastern Nepal
Authors: Poudel Masum , Bhandari Rabin , Uprety Samyog , Chaudhary Ritesh , Yadav Ashok
Published: June 2023

Background: Patient satisfaction is one of the most important indicators of the quality of emergency care. This hospital-based cross-sectional study was performed to assess patient satisfaction in the Emergency department of a tertiary care hospital and identify the factors associated.
Methods: The study was performed on 785 patients visiting Emergency department. Variables under study were satisfaction level, triage score, waiting times, and socio-demographic characteristics. Satisfaction level was measured using a 5-point Likert scale, Cronbach’s alpha (α= 0.86 overall, inter-item α = 0.842-0.859). A score of 47 and above was cut off to denote satisfaction with a sensitivity of 75% and specificity of 81%. Descriptive analysis and Chi-square test was performed to see the association of variables of interests with patient satisfaction. A p-value <0.05 was considered statistically significant.
Results: Median age of the patients was 47 years among which 51% were male. Medical emergencies were the most common problems reported (68.7%). The median (Q1, Q3, maximum) time to first contact with the doctor was 10 (5,15, 240) minutes. The patient satisfaction rate towards the Emergency services was 69%. Behavior of doctors (54%) and nurses’ care (44%) were rated as excellent services while poorer ratings were given for toilet condition (27%) and crowd control (14%). Weekends vs weekdays had a significant association with satisfaction (p = 0.04).
Conclusion: Overall acceptable patient satisfaction rate was found in the services provided by the Emergency department. Areas needing improvement were identified.
INNOVATIVE BUSINESS AS A DETERMINANT OF THE FORMATION OF AN INCLUSIVE ECONOMY
Authors: Honcharenko Oksana , Bahorka Danylo , Efremov Denys
Published: June 2023

The system-forming determinants of functioning of innovative business in the context of inclusive development of the national economy are substantiated.

It is determined that in modern innovative forms of business (outstaffing, outsourcing, consulting, etc.) are organizational innovations, their existence forms fundamentally new economic and legal relations between economic entities and contributes to the implementation of inclusive management strategies and technologies.

It is argued that inefficient basic institutions and existing institutions, non-transparent sales flows, scarcity of credit resources and investments cause low rates of spread of innovative forms of business in the economy. The combination and synergy of these factors limit the positive regulatory influence of economic institutions on innovative modernization and economic development.

It is substantiated that the greatest potential for growth in the national economy is characterized by information and communication technologies and services in this sphere. The growth of the volume of IT services in the national economy and achieving compliance with the innovative development trend will be facilitated by institutional support of outsourcing business technologies in high-tech industries and information and communication sphere.

The criteria for evaluating the effectiveness of outsourcing are defined. Such criteria determine the impact of outsourcing business technology on the result of the activities of producers ordering a service or performing it. The key characteristics for assessing the effectiveness of outsourcing services are: reducing the costs of the production process; optimization of business processes; improving the efficiency of the manufacturer; improving the quality of the production process.

The analysis of trends in the development of innovative forms of business in the national economy has revealed that their development is hampered by low scale and pace of digitalization in most industries, low innovation activity of commodity producers, institutional weakness of regulatory influences, shadowing of the economy and the predominance of quasi-innovations. Evolutionary limitations in the formation of innovative business correlate with technological lag in production, a significant shadow sphere of the economy, permanent political and economic crises.
LONG- AND SHORT-TERM EVOLUTION OF SALE PRICES OF AGRICULTURAL PRODUCTS IN UKRAINE IN 2010-2021
Authors: Dmytriieva Viktoriia
Published: June 2023

The price is an indicator that accumulates information about the cost of production, balance between supply and demand, its quality evaluation by consumers, the variety of offer by manufacturers and other characteristics. The price is formed not only as a mathematically calculated value depending on the cost price or accompanying costs, but it considers the market situation. Prices on agricultural products are influenced by such industry specific as production seasonality.

The source data base was analyzed to study prices evolution for some agricultural products in Ukraine. In particular, the features of changes in price indicators were revealed and described for fruit, berries, potatoes, grains, legumes, and oil crops.

Vegetable price data set was analyzed to reconstruct evolution of price fluctuations for the period of January 2010 - December 2021. Decomposing method was applied to extract trend, seasonal and random components from time series. It allowed to build short- and long-term tendencies on the base of its fluctuations. A multiplicative model was approximated to understand dynamics of price index and reveal its behavior in impact circumstances of nature and economic factors. Price fluctuations for agricultural products is presented monthly and in years. It helped to describe long-term trend of price evolution. Moreover, modelling let us to predict values for 2022 and 2023. Forecasted values were compared with factual data from official statistical sources.

According to results of analysis predicted dynamics almost completely repeated real tendency, in seasonality. Nevertheless, prices of 2022-2023 years were influenced by Russian invasion consequences. Prices soared over the predicted values. That happened because of destruction of the logistics for agricultural products supply, loss of farm assets, contamination of land with explosive substances, rise of inflation, increase of costs and demand on deficient goods, shortening of products and raw supply. At the same time, it is demonstrated that prices of products of so-called "borscht set" have been constantly increasing since 2013. That was caused by inflation and poor harvests. Mentioned factors led to that certain vegetables were imported from abroad.