bluuebunny/crossref_metadata_2025 huggingface dataset:
Podle starého vzoru: rekonstrukce malt, sgrafit a štuků
Authors: Válek Jan , Skružná Olga , Waisserová Jana , Wichterlová Zuzana , Maříková-Kubková Jana , Kozlovcev Petr
Published: April 2022

Publikace dokládá, jakým způsobem může poznání původních materiálů a technik přispět k restaurování a zachování historických stavebních a uměleckých památek. Původní technika je součástí uměleckého díla a může doplnit podstatné informace k historii a vývoji zkoumaného díla. Způsob práce určité dílny se může následně stát důležitým vodítkem při datování či připsání děl uměleckému či řemeslnému okruhu. Poznání původní techniky může změnit uměleckohistorický pohled na umělecká díla minulosti, jako v případě nově popsané techniky stínování sgrafit. Znovuobjevení zapomenutých technik je tak podstatnou součástí kvalitní a smysluplné péče o památky.
Clinical and functional control of mucolytic therapy in children with cystic fibrosis
Authors: Simonova O. I. , Bystrova S. G. , Gorinova Yu. V.
Published: April 2022

The article describes the features of mucolytic therapy in patients with cystic fibrosis, as the leading pathogenetic mechanism of the disease lies in the compromised mucociliary transport due to the presence of viscous secretions. Particular attention is paid to the key mucolytic drug (endonuclear mucolytic) dornase alfa, which has three clinical effects: powerful mucolytic, anti-inflammatory and antibacterial. The extracellular DNA cleavage in secretions results in a decrease of bronchial mucus viscosity, and a decrease in elastase and IL-8 concentrations in sputum results in the reduction of lung tissue destruction in chronic bacterial inflammation. The authors pay attention to the adherence to the drug policy, possible dosing regimens and drug use variants to achieve a clinical effect. Also, the article extensively covers the results of international clinical studies on the use of dornase alfa in cystic fibrosis. The authors presented their own clinical observation – the experience of clinical and functional control over the efficacy of the drug when comparing two groups of children with cystic fibrosis: those who received (2018–2021) and those who did not receive dornase alfa (1995–1998 – before it was introduced into clinical practice). The remarkable thing is that the results of FEV1, MEF 50, MEF 75, PEF were significantly higher in the group of modern children with cystic fibrosis, who receive dornase alfa continuously as part of the backbone therapy, than in children of the same age 25 years ago. It has been substantiated that dornase alfa is one of the main components of the backbone therapy for patients with cystic fibrosis, which should be prescribed on an ongoing basis after the diagnosis has been established, under the functional control of its efficacy
Non-drug treatments for bronchiectasis
Authors: Meshcheryakova N. N.
Published: April 2022

In recent decades, attention to lung diseases associated with bronchiectasis has increased significantly. Despite the availability of modern effective therapy methods, primarily inhalation therapy, the problems of improving mucociliary clearance, reducing hypersecretion in pathologically deformed bronchi do not lose relevance. In patients with bronchiectasis, cystic fibrosis, COPD with bronchiectasis, methods of kinesitherapy to improve lung drainage function come to the fore. One of modern effective methods of kinesitherapy is the use of simulators with positive expiratory pressure. This includes the PARI O-PEP and the PARI PEP S system. These simulators are effective and easy to use. The PARI PEP S system is attached to a nebulizer and the patient can perform basic mucolytic therapy with exhaled resistance, which is more effective in influencing lung drainage function. The use of expiratory simulators is even more effective if included in a pulmonary rehabilitation course, conducted in conjunction with the improvement of breathing pattern (breathing pattern) through the use of aspiratory simulators, with training of the upper and lower muscle groups that are affected by chronic infectious process. The use of hardware methods to improve lung drainage function, such as vibration and compression therapy, is important to manage exacerbations of bronchiectasis. Due to the pandemic of new coronavirus infection (COVID-19), it is necessary to prevent worsening of the course or exacerbation of lung diseases associated with bronchiectasis, so the daily use of physical training, aspiration training and expiratory exercise machines is essential.
The use of targeted therapy lumacaftor/ivacaftor in patients with cystic fibrosis
Authors: Chermensky A. G. , Gembitskaya T. E. , Orlov A. V. , Makhmutova V. R.
Published: April 2022

Accepted, basic therapy of cystic fibrosis (CF), until recently, was symptomatic and aimed at slowing down pathological processes, mainly from the respiratory system and gastrointestinal tract, caused by a defect in the CFTR gene. New strategic opportunities have emerged since 2012 and are aimed at correcting a defect in a gene or its product. A mutation in the cystic fibrosis gene disrupts the function of the cystic fibrosis transmembrane conductance regulator protein (CFTR or CFTR in English transcription), which is located on the surface of the apical membrane of epithelial cells and functions as a chloride channel. The basic achievement for the new CF therapy was the discovery of small molecules that restore the processes of synthesis, transport to the membrane, or the  functioning of  the defective CFTR protein. The effectiveness of  drugs that restore CFTR function is related to the ability of the molecules to deliver an adequate amount of the CFTR protein to the surface of the epithelial cell and/or improve its functional activity. Among them, correctors and potentiators for pharmacological modulation of ion transport are distinguished in clinical practice. Correctors are medicinal substances that allow the mutant CFTR protein to pass through the system of intracellular quality control and take the correct location on the apical membrane (with class II mutations). The action of potentiators is aimed at restoring (activating) the function of the ion channel formed by the mutant CFTR protein (class III–IV mutations). The purpose of this article is to analyze the literature sources, the results of clinical trials on the use of CFTR modulators, including combinations of a potentiator and a corrector. Their effectiveness and safety were evaluated. Literature sources (20) are used and own clinical observation is given. A positive assessment of the action of the modulator, the combination of a potentiator and a corrector, its safety and good tolerability is given. In conclusion, the place and indications for prescribing drugs of this class, the number of patients in the Russian Federation in need of such treatment are determined.
A SEXUALIDADE EM TEMPOS DE COVID-19: O USO DE MÍDIAS SOCIAIS POR HOMOSSEXUAIS NA PANDEMIA
Authors: Bortolozzi Ana Cláudia , Mendes Cordeiro Caique , Spadotto de Carvalho Leilane Raquel
Published: April 2022

Diante da pandemia do COVID-19, muitos problemas na saúde mental e nos relacionamentos afetivos e sexuais surgiram em decorrência das ações para a prevenção e o controle da doença. A chamada “quarentena” impôs às pessoas uma vida de isolamento social com restrições de contatos com amigos, parentes e vínculos amorosos estáveis ou não. O público homossexual ainda costuma esconder a expressão de seus desejos e vínculos eróticos em uma sociedade preconceituosa, utilizando-se de mídias sociais como alternativas para a busca de parceiros e encontros. Este estudo teve por objetivo investigar a opinião de 72 pessoas homossexuais ou bissexuais sobre o uso de mídias digitais para relacionamentos afetivos e sexuais antes e durante o período de isolamento, devido a prevenção ao contágio do COVID-19, que responderam a um questionário on line, para análise quantitativa. Os resultados mostram que a maioria dos/as entrevistados/as afirmou que os relacionamentos antes da pandemia mantiveram-se e houve um aumento da utilização das mídias sociais com seus parceiros/as com fins sexuais. Antes da pandemia o motivo principal do uso de aplicativos de relacionamentos era o de “marcar encontros”, mudando em tal período para a função de “ter com quem falar” ou deixaram de ser usados. Conclui-se que o público LGBTQ+ vivencia maior vulnerabilidade sexual e afetiva no período de isolamento social e profissionais da área da saúde mental devem oferecer mais atenção para essa população.
PAULO FREIRE E O DIÁLOGO: INTERFACES ENTRE A SAÚDE PÚBLICA E A EDUCAÇÃO ESCOLAR
Authors: Luft Hedi Maria , Da Silva Mota Daniela , Silva Camila Sousa da
Published: April 2022

Este estudo trata de compreender as relações humanas nos processos de acolhimento e atendimento na educação escolar e na saúde pública para analisar as várias interfaces da pessoa humana, considerando-a um ser multidimensional. As relações são estabelecidas por e para humanos, e este aspecto precisa ser levado em conta de modo contextualizado, favorecendo perspectivas de impulso e orientação para a construção de práticas humanizadoras. A abordagem metodológica consiste em um estudo qualitativo e utiliza-se da análise de conteúdo sobre duas obras de Paulo Freire (Pedagogia do oprimido e Educação e mudança), constituindo um corpus de análise organizado segundo as categorias a priori: a educação escolar e a saúde pública. O estudo enfoca os ganhos alcançados por um grupo de balsenses que, por meio de um projeto realizado em uma escola municipal da zona rural, com vistas à preservação do meio ambiente em parceria com profissionais da saúde, trouxe orientações pedagógicas aliadas às atividades de conscientização junto ao atendimento de saúde sobre as dificuldades de lidar com os resíduos produzidos, destacando o diálogo como método e estratégia de melhor convivência e de vida mais saudável. Delineia-se resultados de uma reflexão que, baseada na pedagogia humanizadora, confere dignidade aos sujeitos e favorece a construção de princípios e o cultivo de valores que desencadeiam outras compreensões promotoras de movimentos de superação de modelos desumanizadores.
Effective dilution rate to suppress the risk of Microcystis blooms in Lake Tega, Japan, based on a competitive growth simulation model
Authors: Li Jingnan , Chujo Masato , Amano Yoshimasa , Machida Motoi
Published: April 2022

Although water transfer as an efficient method to improve water quality and control Microcystis blooms in lakes has been executed for several decades, few studies have examined effective dilution rates depending on various water qualities. Therefore, to clarify the effective dilution rate to suppress Microcystis blooms, a competitive growth simulation model developed for eutrophic conditions was utilized. A competition experiment between Microcystis sp. and Cyclotella meneghiniana under limited phosphorus and sufficient nitrogen concentration was conducted to investigate the mechanism of dilution effect and verify the broad applicability of the simulation model. Experimental results revealed that there was no remarkable discrepancy in Microcystis sp. cell density among different dilution groups (p>0.05), while C. meneghiniana cell density was significantly different between groups (p<0.05). The accuracy of the simulation model under limited phosphorus as well as sufficient nitrogen concentration was verified by comparing the simulated value with experimental results. Based on the simulated results, it was suggested that a dilution rate of over 13.3% can suppress Microcystis blooms effectively in Lake Tega, Japan, as a case study. The predicted data was also compared with the field data collected over years in Lake Tega, and its effectiveness has been confirmed.
Transitividade e variação construcional
Authors: Silva José Romerito , Furtado da Cunha Maria Angélica
Published: April 2022

Neste artigo, tratamos da variação em construções transitivas. Nele, discutimos questões relativas ao uso de padrões distintos de codificação da construção transitiva com praticamente o mesmo significado. Nosso objetivo é identificar motivações funcionais favorecedoras da utilização de um ou de outro padrão disponível considerando a frequência token dos types construcionais. Como orientação teórico-metodológica, adotamos a Linguística Funcional Centrada no Uso de viés construcionista. O estudo é predominantemente qualitativo, apoiando-se em suporte quantitativo como instrumento de balização da análise. Para tanto, utilizamos dados de fala e escrita em variados gêneros de fontes diversas. Os resultados apontam a influência de fatores como analogização, por similaridade em grupos de construções com variantes formal e semanticamente aproximadas, e modalidade de língua, considerando o grau de (in)formalidade do contexto discursivo.
Morfologia Relacional: o que é e como se faz
Authors: Gonçalves Carlos Alexandre
Published: April 2022

O objetivo central do artigo é fornecer ao leitor um panorama geral acerca de um novo modelo que se inscreve no conjunto das abordagens construcionistas da gramática: a Morfologia Relacional (JACKENDOFF; AUDRING, 2016, 2018, 2010). Nessa empreitada, destacamos os pontos de convergência e de divergência entre a Morfologia Relacional e outras abordagens congêneres, como a Morfologia Construcional (BOOIJ, 2005; BOOIJ, 2010), mostrando seu formalismo e aplicação a fenômenos morfofonológicos do português, como, por exemplo, os plurais em -ãos. Como é uma abordagem extremamente recente, ainda pouco conhecido no Brasil, pretendemos apresentar o modelo, além de argumentar em prol do seu poder descritivo com dados do português.
Linguística Funcional Centrada no Uso: teoria, método e aplicação
Authors: Bispo Edvaldo Balduino , Guimarães Lopes Monclar
Published: April 2022

Neste texto, apresentamos o número especial 2022 da Revista Odisseia, organizado para abrigar trabalhos voltados para as mais recentes tendências de pesquisa na área da Linguística Funcional Centrada no Uso. De início, partimos da contextualização dessa perspectiva linguística no cenário acadêmico brasileiro, explicitando sucintamente seus pressupostos teóricos e categorias analíticas. Contemplamos aspectos de ordem conceitual e metodológica com que pesquisadores funcionalistas passaram a lidar devido à incorporação de postulados e conceitos operacionais da Gramática de Construções. Por fim, descrevemos os trabalhos que compõem este dossiê, os quais se voltam tanto para a reflexão e/ou a discussão de questões teóricas e metodológicas quanto para a aplicação desse viés funcionalista à descrição e à análise do português.
Role of Serum Cystatin C as a Diagnostic Tool for Renal Function in Cirrhotic Patients
Authors: Asal Fathia Elsayed , Yousef Mohamed , Abdraboh Hend Atteya Abdelkhalek , Abd-Elsalam Sherief , Abdelaziz Shama Ahmed Abdelaziz , Elbahnasawy Mohamed , Elnaggar Mohammed H , Alsrogy Hesham Ahmed , Elashry Heba
Published: April 2022

Background:

Assessment of cystatin C levels could be valuable in the early detection of renal dysfunction because they increase faster than the creatinine levels as the GFR decreases. The aim of this work was to evaluate serum cystatin C as a diagnostic tool for renal dysfunction in cirrhotic patients with and without hepatorenal syndrome (HRS).

Methods:

This case-control study was conducted on 60 patients from the Tropical Medicine Department of Tanta University Hospitals and 10 people served as healthy control volunteers. Serum cystatin C was measured in the three groups.

Results:

A significant difference was observed among the three groups as cystatin C was higher in patients with HRS compared to the cirrhotic group and healthy controls.

Conclusion:

Serum cystatin C is a good predictor for hepatorenal syndrome with a good correlation with serum creatinine, blood urea, GFR, and creatinine clearance.
The Creative Writer's Mind
Authors: Krauth Nigel
Published: April 2022

The Creative Writer’s Mind is a book for creative writers: it sets out to cross the gap between creative writing and science, between the creative arts and cognitive research. It examines what cognitive psychology, neuroscience and literary studies can tell creative writers about the processes of their writing mind.
APORTE AL CONOCIMIENTO DEL ÁMBITO GEOGRÁFICO DE LA SALAMANDRA Chiropterotriton ceronorum
Authors: Aguilar-López Jose Luis , Pineda Eduardo Octavio , García-Bañuelos Paulina
Published: April 2022

Se reporta la presencia de Chiropterotriton ceronorum en una nueva localidad, la cual amplía la distribución geográfica de esta especie 14.3 km al norte de la localidad histórica más cercana. Adicionalmente se aporta información sobre la ecología de la especie.
FIRST RECORD OF A VERTEBRATE IN THE DIET OF THE GENUS Geophis
Authors: Arteaga-García Stephania , Valdenegro-Brito Antonio Esau , Garcia Vazquez Uri Omar
Published: April 2022

The Coral Earth Snake (Geophis semidoliatus) feeds mainly on invertebrates. In this note we present the first record of a vertebrate (Scincella cherriei) in the diet of the snake Geophis semidoliatus.
Comparative Clinical Study of Hijama bil shart (Wet Cupping) and Hijama bil nar (Fire Cupping) in Irq al- nasa’ (Sciatica)
Authors: Aziz Abdul , Rather Shameem Ahmad , Bhat Shabir Ahmad
Published: April 2022

Background: ‘Irq al nasa’ an Arabic term to which we call ‘Sciatica’ is clinically defined as the pain along with Sciatic nerve and its component nerve roots. Pain may vary from mild ache to severe burning or shooting, or tingling in nature. According to Unani literature, sciatica (Irq al-nasa') may be caused by accumulation of morbid matter or phlegm (Khilt balgham galeez) in the affected area. “Hijama” means “to suck” is a Unani regimental method of treatment, which helps to evacuate the morbid materials from the body and reassure the blood flow to the site of Hijama.

Objective: This study aims to compare the efficacy and safety of hijama bil-shart (wet cupping) and hijama bil-nar (fire cupping) in the management of sciatica.

Methods: In an open, randomized, controlled study out of 70 sciatica patients, 60 were randomly allocated in test and control group, 30 in each. The test group received wet cupping and control group were applied with fire cupping at 0th, 15th, 30th and 45th day.

Results: While observation of visual analogue scale for pain, limb movement, straight leg raising test, deep tendon reflexes at ankle and knee joint, and stiffness along with Bragard’s sign, the intergroup comparison of pre and  post treatment results showed wet cupping is more effective than fire cupping (p<0.001).

Conclusion: Hijama bil-shart (wet cupping) is more effective than hijama bil-nar (fire cupping) in managing sciatica. Both the therapies were generally well tolerated.

Keywords: Cupping, Hijama, Sciatica, Unani.
Relationship of Knowledge in Women Age 25-50 Years in RW 05 Cibubur, East Jakarta on BSE Knowledge as Early Detection of Breast Cancer
Authors: Suryanegara Wiradi , Gultom Fajar Lamhot
Published: April 2022

In Indonesia, based on Indonesia’s Health Profile 2008, the top 10 major malignant neoplasm disease or cancer inpatients at the hospital since 2004-2008 has not changed much. The first rating is breast malignant neoplasm or breast cancer. Society rarely knows that it is important to perform BSE (breast self-examination) early, which can help reduce the incidence of morbidity or mortality of breast cancer patients. The purpose of this study was to determine the relationship between knowledge in women aged 25-50 years at RW 05 Cibubur, East Jakarta, on BSE as early detection of breast cancer. This research employed an analytic survey with the cross-sectional approach. The employed technique in sampling was simple random sampling. It was done with the lottery technique to population members. The results of the 207 respondents showed that respondents with bad BSE knowledge were 100 people (48.3%) and respondents with good knowledge were 107 (51.7%). The respondents who practiced the BSE were 95 (45.9%), and the respondents who did not were 112 people (54.1%). The statistical test results had a very strong correlation with the value of 0.832 and correlated with the statistical value of 0.000.

Keywords: Breast Cancer, Knowledge, BSE (Breast Self-Examination), Women Aged 25-50 Years at RW 05 Cibubur East Jakarta.
Assessment of Prescribing Patterns of Antihypertensive Drugs and Risk Factors Associated with Hypertension in Tertiary Care Hospital
Authors: Tom Cyril , John Ajo , SA Babu Arya , Sahil Mohammed , Narayanan Navya
Published: April 2022

Aim/Background: To assess the prescribing pattern of anti-hypertensive and to assess the risk factors associated with hypertension.

Materials and methods: The prospective observational study was carried out for 6 months among 31 in-patients in the various departments of Yenepoya Medical College Hospital, Mangalore.  Patients of both sex aged 18 years and above, those who can understand oral and written information and those diagnosed with hypertension were added in the study. Out-patients, patients with mental or psychiatric diseases, cognitive dysfunction, patients on cancer chemotherapy, pregnant and lactating females were excluded. A suitably designed data collection form was prepared to collect the data.

Results: Out of 31 patients, hypertension was mainly affected in males above the age of 60years. In the study, majority (41.9%) of the participants had Stage II Hypertension according to JNC 7 classification. The major risk factors associated with Hypertension was advanced age (41.9%) followed by alcoholism (12.9%) on basis of environmental risk factor and diabetes (64.5%) on disease basis.  Study reveals that Type II DM was comorbidity in most of the patient’s i.e., 19(61.3%), followed by 15(48.4%) patients with CKD. 25.8% patients recieved monotherapy while majority of the patients i.e., 74.2% received triple therapy. The most commonly prescribed drug was Furosemide (Diuretics) 18(58.1%), followed by Clonidine (Alpha agonist) 13(41.9%). The result also shows that, after health education for patients with hypertension, BP is substantially lowered.

Conclusion: Study reveals that advancing age was the most predominating risk factor among hypertensive patients. Diuretics (Furosemide), Alpha agonist (Clonidine) and Calcium channel blocker (Amlodipine) were the drug of choice for hypertensive patients in the hospital. Drug therapy along with patient counseling helped to lower BP to an extent.

Keywords: Antihypertensive drug, prescribing pattern, risk factors, hypertension, co-morbidities with hypertension
Antibiotic prescription practice at veterinary pharmaceutical shops and its potential impact on the development of antimicrobial resistance in Moshi, Northern Tanzania
Authors: MKALA REUBEN SUNZU
Published: April 2022

Aim: We aimed to investigate antibiotic prescription practice in veterinary shops and its potential impact on the development of antimicrobial resistance.

Methods: A correlation cross-sectional study was carried out in Moshi, Tanzania. A convenient sampling method was used to enroll 80 study participants and 80 Veterinary pharmaceutical shops selling antibiotics for cattle. The study questionnaire was administered to both pharmaceutical sellers and cattle keepers Results: A total of 80 veterinary pharmaceutical shops visited to deliver information about antibiotics sold with or without prescription from veterinary professionals and eighty (80) human participants. Most of the study participant 66/80 (82.5%) responded to started treatment before laboratory diagnosis and diagnosis was mainly based on symptoms and signs 58/80 (72.5%); owners description 17/80 (21.3%) and less frequently on none specific reason 15/80 (6.5%) (Χ2=77.89, P= 0.000, OR=0.875, 95% CI= 0.803-0.947). Tetracycline 30 (100%), Trimethoprim/sulfamethoxazole 10 (100%), and amoxicillin/clavulanic acid 7 (100%) were highly sold unprescribed drugs and no quantity of these drugs was prescribed before selling at Veterinary pharmaceutical shops.

Conclusion: The regulation of Veterinary antibiotic prescription at veterinary pharmaceutical shops has to be a point of discussion and paid greater attention to ensure a sustainable control and reduction of transmission and spread of drug-resistant bacteria in humans and cattle.

Keywords: antibiotic prescription practice, antimicrobial resistance, Veterinary pharmaceutical shops
The role of the general practitioner in promoting organ donation
Authors: Jandou Issam , Rania Alafifi , Kbirou Adil , Mahmoud Alafifi , Moataz Amine , Dakir Mohammed , Debbagh Adil , Aboutaieb Rachid , Hassoune Samira
Published: April 2022

Introduction: The effectiveness of a health system is based on primary care, the conductor of which is the general practitioner, who is also an integral part of the organ donation promotion chain. At present, as the indications for transplantation are more and more widespread, an immense shortage of organs is declared. This pushes more than ever to multiply creative tactics to reduce the gap between the number of high demand and stingy supply.

The main objective of this work is to particularize the involvement of the general practitioner in this process of encouraging donation, as well as to highlight his attitudes and his motivation during the consultation, and to identify the possible obstacles to the donation. Information and patient education on organ and tissue donation.

Material and method: A quantitative descriptive cross-sectional study, based on a questionnaire with 20 closed questions, self-administered, sent by email address, completed anonymously and voluntarily intended for the general practitioner of the region of Casablanca. Questionnaire data were collected, coded, and analyzed using SPSS-PC (Version 21.0).

Results: In total, 200 general practitioners were targeted by our study. 165 responded to the questionnaire, which gives an overall response rate of 82.5%. 35.5% of the participants were women, the duration of exercise varies between 1 and 40 years, 65% of the doctors practiced in the urban environment and approximately 59.5% worked in the liberal sector. 87% of the doctors questioned were in favor of organ donation. only 38% of doctors have already discussed this subject with their patients, of whom more than 64% were following the sole initiative of the patient himself and in none of the cases was awareness-raising through posters in the waiting room.

Conclusion: The general practitioner is a cornerstone of the success of public health programs. Continuous training of this category of doctors ensures better promotion of organ and tissue donation in Morocco.

Keywords: tissue donation, blood donation, donors and non-donors of the without, federating donors, Morocco
Comparative antimicrobial efficacy of ayurvedic formulations; Satva and Ghana of Tinospora cordifolia (Willd.) Miers (Giloy) against commensals and opportunistic pathogens
Authors: Javed Danish , Anwar Sana , Pathan Saman
Published: April 2022

In our classical Ayurvedic texts, it has been described as beneficial in treating various types of diseases. Tinospora cordifolia satva (TCS) and Tinospora cordifolia ghana (TCG) is one of the unique Ayuvedic classical preparations, prepared from aqueous of extract of Giloy (Tinospora cordifolia Miers.) stem. These are frequently used medicines for the treatment of Madhumeha, Pandu, Kamala, Amlapitta, Grahani, Kustha, Jirna Jwara and Viswamjwara, Trishna, Shool, Yakritavikara, etc. Therefore, an attempt was made in this study to evaluate antimicrobial efficacy of these two dosage forms i.e. TCS and TCG. Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae and Propionibacterium acnes were used for antimicrobial evaluation and the classical method was used for the testing. The results shows that TCS can be considered as comparatively more potent antimicrobial than that of TCG at lower concentration on studied strains of E. coli, P. acnes.

Keywords: Guduchi satva, Guduchi ghana, Giloy, Tinospora cordifolia, anti-microbial activity, commensal pathogens
A Review on Pharmacological and Therapeutical Insight of Satranidazole for Colon Targeting in the treatment of Colonic Diseases
Authors: Ghosh Soumyadip , Ganguly Debgopal , Majumder Subhabrota , Chowdhury Ananta
Published: April 2022

Drugs targeting the colonic environment to treat various colonic diseases are the major challenges recently. Various drugs are available in the markets to targeting to the colonic region to treat diseases but due to premature drug releases, target specificity, the low concentration at the target site with high adverse effects which increase patients’ compliance day by day. Satranidazole is a promising drug that is particularly targeting the colonic environment and can break down microorganism DNA to involve the treatment of several diseases such as inflammatory bowel diseases subdivided Ulcerative colitis, Crohn’s disease, amoebiasis, chronic diarrhea, and reduction of pain due to inflammation. Conventional drug delivery of Satranidazole has some disadvantages such as target specificity, high dosing frequency, low therapeutic efficacy, and high adverse effects that can be overcome through targeted drug delivery systems. Satranidazole is successfully showing the efficacy against aerobic, microaerophilic as well as anaerobic bacterial and reduction of inflammation of inflammatory bowel diseases subdivided as Ulcerative colitis and Crohn’s disease. It is a much more potent drug than metronidazole and has fewer adverse effects. Satranidazole is more convenient for oral administration compared to other routes of administration to show activity. Researchers are giving much more attention to targeted drug delivery systems of Satranidazole to show high therapeutic activity with fewer side effects. The current review focus on the pharmacological and therapeutical insight of Satranidazole in the treatment of colonic diseases and recent advancement and the future aspects of Satranidazole targeting various diseases. 

Keywords: Satranidazole, Inflammatory bowel diseases, Ulcerative colitis, Crohn’s disease, Amoebiasis, Targeted drug delivery system, Future advancement, Colonic drug delivery systems.
The Use of Incision Wound Model to Improve the Clinical Skills of Nursing Students
Authors: Iriana Pramita
Published: April 2022

Nursing education curriculum plays a significant role in preparing nursing graduates to begin clinical practice in the field. It is important to develop several learning methods, like skill-lab practice media, in order to enable students to practice more often before engaging in actual clinical practice and obtain a simulated picture that is close to reality. The objective of this research is to determine the effectiveness of a portable postoperative incision wound model on the clinical skills of nursing students. The quasi-experimental research method used pre and posttest evaluation in control and intervention groups. The intervention group used a portable incision wound care model during practice. Stratified random sampling was performed as a sampling method with 45 students in each group. The data were analyzed using dependent and independent t-tests, with a significance value of 0.05. All students scored above the passing grade limit (2.76). The mean difference among students using the portable wound care model increased by 0.31 and was higher than that in the control group, with an increase in the difference value by 0.26. The p value in both groups is 0.001

Keywords: Clinical skills, Portable wound model, Clinical skill-lab, Instructional media
Catherine Harbor in the history of the Red Banner Order of Ushakov of the Northern Fleet (to the 125th anniversary of the Main Hospital of the Northern Fleet)
Authors: Simonenko V. B. , Abashin V. G. , Ivashova  I. A.
Published: April 2022

The article presents the results of a study of the history of the Catherine Harbor, the city of Alexandrovsk-on-Murmansk (Polyarny), and the creation of the Main Hospital of the Northern Fleet. The biographical data of the first county and marine doctors of the Kola Bay are given.
Sequência didática: alimentação balanceada, nutrientes e ligações químicas! Como estão ligados?
Authors: Ogasawara William Hitoshy , Assai Natany Dayani de Souza , Delamuta Beatriz Haas
Published: April 2022

O estudo das ligações químicas é um conteúdo central da Química, uma vez que estabelece relação direta para o entendimento de outros conceitos. Além disso, esse conteúdo possui uma variedade de dificuldades associadas à sua aprendizagem como apontado pela literatura. Assim, o objetivo deste artigo é propor e avaliar uma sequência didática pautada na abordagem temática dos Três Momentos Pedagógicos, para trabalhar o conteúdo de Ligações Químicas, mediante discussões a respeito da alimentação balanceada. Os dados que compõem essa investigação contemplam a aplicação da sequência didática para uma turma da 2ª série de um curso de formação docente: magistério de um colégio público, situado na zona rural de uma cidade localizada no norte do Paraná. A análise dos dados ocorreu a partir dos três distintos momentos da SD, à luz da Análise de conteúdo. A sequência didática elaborada permitiu abordar, definir e diferenciar as ligações iônicas de ligações covalentes, por meio da pirâmide alimentar, proporcionando aos alunos um espaço para compartilharem suas ideias do que seria uma boa alimentação, e repensarem sua própria alimentação, com os conhecimentos das propriedades e composição dos nutrientes a partir do estudo das ligações iônica e covalente.
A inserção do ensino de fitoterapia como práticas integrativas e complementares na formação de enfermeiros: uma revisão integrativa sobre a atuação do docente
Authors: Rodrigues Daniela Cristina Podadera , Pezuk Julia Alejandra
Published: April 2022

Este estudo corresponde a uma revisão integrativa sobre a atuação do docente e as limitações que os mesmos enfrentam para a capacitação em fitoterapia na formação de enfermeiros prescritores. O principal objetivo desta pesquisa foi discutir as informações publicadas em artigos científicos acessíveis na literatura que tratem dos empecilhos encontrados pelos professores dos cursos de enfermagem no preparo para a prescrição de fitoterapia.
Contribuições de mães, escolas e especialistas no processo de desenvolvimento de três crianças autistas em região do semiárido baiano
Authors: Shaw Gisele Soares Lemos
Published: April 2022

Considerando a capacidade de plasticidade cerebral de indivíduos na infância e a importância de intervenção precoce em casos de Transtorno do Espectro do Autismo (TEA) investigou-se, qualitativamente, contribuições dos grupos – família, escola e especialistas, para o processo de desenvolvimento de três crianças autistas do município de Senhor do Bonfim, Bahia, Brasil. Os dados foram coletados por meio de entrevistas semiestruturadas realizadas com mães, professoras e especialistas dessas crianças. Depois, foi realizada análise de conteúdo, que indicou que as três crianças tiveram avanços quanto à redução de sintomas do TEA e que houveram colaborações efetivas de pais e terapeutas e uma menor participação de algumas escolas nos progressos dessas crianças.
Factors related to gender cyber-victimization in social networks among Spanish youth
Authors: Donoso Vázquez Trinidad , Rubio Hurtado Maria Jose , Vilà Baños Ruth
Published: April 2022

This work sought to identify factors associated with gender cyber-victimization in social networks related to technological (participants’ use of virtual environments and digital competences), cognitive (participants’ concept of gender cyber-violence and perception of risk in online activities), and behavioral factors (participants’ responses to cyber-violence). This is an innovative approach to measuring the phenomenon (identifying predictive factors) since previous studies have measured generalized cyber-violence through types of conduct found on the internet, sex-related differences, or studies focused on the sphere of partner relationships. The research was carried out with a sample of 4,536 adolescents aged 12 to 14, all of them in compulsory secondary education in six different regions of Spain. An instrument consisting of different scales was applied, and the data were analyzed using descriptive, predictive and classifying techniques. The variables identified as predictors during the regression analysis and as characterizers of cyber-victims in the clusters are: wider and more intensive use of social networks; more proactive responses to cyber-violence; lower competences in digital self-protection; a more limited concept of gender cyber-violence; and less awareness of risk in some online behaviors. These results suggest a need to intervene in education in order to minimize the risks exposed.
Early initiation of short-term emollient use for the prevention of atopic dermatitis in high risk infants -- the STOP AD randomised controlled trial
Authors: Hourihane Jonathan , Chaoimh Carol Ní , Lad Dhanis , Nico Claudio , Puppels Gerwin J. , Wong X.F.Colin C. , Common John E. , Murray Deirdre , Irvine Alan
Published: April 2022

Background Protecting the skin barrier in early infancy may
prevent atopic dermatitis (AD). We investigated if daily emollient use
from birth to 2 months reduced AD incidence in high risk infants at 12
months. Methods This was a single-center, two-armed,
investigator-blinded, randomized controlled clinical trial
(NCT03871998). Term infants identified as high risk for AD (parental
history of AD, asthma or allergic rhinitis) were recruited within 4 days
of birth and randomised 1:1 to either twice-daily emollient application
for the first 8 weeks of life (intervention group), using an emollient
specifically formulated for very dry, AD-prone skin, or to standard
routine skin care (control group). The primary outcome was cumulative AD
incidence at 12 months. AD <6 months was diagnosed based on
clinical presence of AD. The UK Working Party Diagnostic Criteria were
applied when diagnosing AD between 6 and 12 months. Results 321
infants were randomised (161 intervention and 160 control), with 61
withdrawals (41 intervention, 20 control). The cumulative incidence of
AD at 12 months was 32.8% in the intervention group vs. 46.4% in the
control group, p = 0.036 [Relative risk (95%CI): 0.707 (0.516,
0.965)]. One infant in the intervention group was withdrawn from the
study following development of a rash that had a potential relationship
with the emollient. There was no significant difference in the incidence
of skin infections between the intervention and control groups during
the intervention period (5.0% vs. 5.7%, P>0.05).
Conclusions This study has demonstrated that early initiation
of daily specialized emollient use until 2 months reduces the incidence
of AD in the first year of life in high-risk infants.
A Case of Knuckle Pad Syndrome in a Middle-Aged Man
Authors: Chandler Zachary , Seamon Kimberly , Ramsubeik Karishma , Kaeley Gurjit
Published: April 2022

Knuckle pads are benign papules, nodules, or plaques overlying joints
and typically manifest at the proximal interphalangeal joints. They may
be confused with other dermatologic or rheumatologic diseases. Treatment
options for primary knuckle pads are limited and acquired knuckle pads
typically improve with withdrawal of the offending insult.
Importance of early recognition and treatment of tuberculous aortitis
Authors: Nakamura Yoshihiro , Asada Kazuhiro , Toyama Masashi , Fujita Yoshiro
Published: April 2022

Tuberculous aortitis is difficult to diagnose, but early treatment may
limit the progression of tuberculosis aortitis, which may cause aortic
stenosis or pseudoaneurysm formation if untreated. We provided
antituberculous therapy on suspicion of tuberculous aortitis, despite
the lack of definitive diagnosis, and obtained a favorable outcome.
Long-term care issues in a municipality affected by the Great East Japan Earthquake: A case of Katsurao Village, Fukushima Prefecture
Authors: Zhao Tianchen , Moriyama Nobuaki , Ito Naomi , Abe Toshiki , Morita Tomohiro , Nishikawa Yoshitaka , Tsubokura Masaharu
Published: April 2022

Katsurao Village, one of the affected municipalities after the Fukushima
nuclear accident, faced problems associated with care for older people,
necessitating the need to examine the measures to deal with these issues
in the affected areas.
Recurrent Alterations in the MAPK pathway in Sporadic Pyogenic Granuloma of Childhood
Authors: Strobel Katharina , Maurus Katja , Hamm Henning , Roth Sabine , Goebeler Matthias , Rosenwald Andreas , Wobser Marion
Published: April 2022

Pyogenic granuloma is one of the most common vascular tumours. The cause of pyogenic granuloma was previously thought to be an inflammatory reaction with consecutive stimulation of endothelial cell proliferation. However, recent studies suggest that pyogenic granuloma may be driven by constitutive activation of the mitogen-activated protein kinase pathway. The aim of this study was to investigate the molecular profile of sporadic pyogenic granuloma of childhood, using a systematic approach scrutinizing potential aberrations within different oncogenic pathways. Within a retrospective setting pyogenic granuloma of 15 patients was analysed by targeted next generation sequencing using the Oncomine Focus Assay, which includes genes of key tumorigenic signalling pathways. Activating mutations were found in 4 out of 15 cases (27%). Two HRAS hotspot mutations (p.Gly13Arg, p.Ala59Thr), 1 BRAF (p.Val600Glu) mutation and a novel, previously not reported, MAP2K1 hotspot mutation (p.Glu203Lys) were identified. It is notable that all of these genes are involved in constitutive mitogen- activated protein kinase signalling. This study increases the range of underlying genetic alterations in pyogenic granuloma by identifying novel oncogenic mutations in crucial mitogen-activated protein kinase pathway genes. The results provide supporting evidence that activated mitogen-activated protein kinase signalling is a key driver in the pathogenesis of pyogenic granuloma, which might be exploited by targeted treatment approaches for selected cases.
Profesjonelt kunstnerisk agentskap. Strategier for prosjektmakeri og jobbskaping
Authors: Vinge John , Stavrum Heidi
Published: April 2022

In this chapter, we pay special attention to the musicians who establish their own projects, who manage their own businesses, raise funds and also generate income for others. Through four narratives we describe and discuss the choices the musicians make and the strategies they use to seize opportunities in the field to create a foundation for their own professional development. Rather than understanding the musicians’ actions and choices based on the forces acting on them, we draw attention to the musicians’ actions as a result of professional artistic agency, with the aim of identifying characteristics that constitute such agency.
Musikerne – hvor mange er de egentlig? Avgrensninger i politikk og forskning
Authors: Heian Mari Torvik
Published: April 2022

There are more professional musicians in Norway than any other type of artist, and their numbers seem to be constantly increasing. Nationwide surveys conducted in 1993, 2006 and 2013 have documented that the number of musicians exploded over this period. This strong increase is partly due to genuine growth, but first and foremost because the criteria for inclusion in the artist population were expanded in the survey from 2006. In 2021, a new artist survey was conducted, and the musicians were among the artists counted. The purpose of this chapter is 1) to discuss different delimitations and data sources for estimates of the number of musicians and 2) to reflect on the implications of different definitions of the research object ‘professional musician’.
Profesjonalitetens pris – om ambivalens og profesjonalisering blant konsertarrangører
Authors: Kleppe Bård , Berge Ola K.
Published: April 2022

In the fields of art and music, professionalization is an important prerequisite for success in an increasingly globalized and competitive market. In Norway, professionalization is a recurrent topic in policy papers, and several cultural policy schemes aim at increased professionalization. Professionalism is also a key concept when referring to musicians and artistic activity. Who are professionals and who are amateurs decides who are inside and who are outside when recognition and grants are to be awarded. At the same time, professionalization also comes with a considerable downside, which is largely undescribed and unrecognized. In this paper, we discuss the term professionalization both as a theoretical as well as a rhetorical concept. Based on two different studies of concert promoters, we describe and analyse the downsides, both in terms of increased expenses and reduced enthusiasm among volunteers.
The Use of Infographics, Tables and Graphs in the Hospitals and Health Services Quality Account in Australia
Authors: Halabi Abdel K , Brown Lee
Published: April 2022

Objective: This study will investigate whether removing the Quality Accounts purpose and aim led to differences in the number of Infographics, Tables and Graphs used over four years.
Design: A content analysis was performed on the Quality Accounts of six Hospitals and Health Services from 2016 to 2019. Statistical analysis was then performed to examine differences in the use of Infographics, Tables and Graphs in the Quality Account
Setting: The six Hospitals and Health Services were operating in a rural geographical area in the state of Victoria, Australia.
Results: Even though some significant differences were found , this was largely due to yearly variability in the use of Infographics, Tables and Graphs. The six Hospitals were quite different in their Quality Account presentations because these reports are structured to a particular community.
Conclusions: The removal of the purpose and aim has not affected the number of Infographics, Tables and Graphs. While limitations are noted, a number of future research opportunities stem from this study to enhance the Quality Account and overall understandability of Hospital reports.
Evaluation of Service-Oriented Nursing Supervisor Strategy Based on Data Envelopment Analysis (DEA)
Authors: Hamzehzadeh Farhad , Mirzaee Fateme , Jalali Alireza , Ahmadinejad Bahareh , Shahmoradi Hoshang , Navand Anis
Published: April 2022

Background: This study introduced a service-oriented nursing supervisor strategy to increase the performance efficiency of different hospital wards. The efficiency of this strategy in 12 wards under the supervision of 12 supervisors was evaluated using Data Envelopment Analysis (DEA).
Materials and Methods: The efficiency of the service-oriented nursing supervisor strategy was evaluated using DEA. This study aims to evaluate the relative efficiency of hospital wards before and after implementing the service-oriented nursing supervisor strategy at Milad hospital. Data were evaluated using two basic models of data envelopment analysis technique, i.e., CCR and BCC output-oriented methods. Then, the relative performance efficiencies of 12 wards in 2 periods, including the first half of 2020 (before service-oriented nursing supervisor strategy) and the second half of 2020 (after service-oriented nursing supervisor strategy) were analyzed. Finally, efficient wards were ranked using the Anderson-Peterson method based on the results.
Results: According to the CCR output-oriented method, after implementing service-oriented nursing supervisor strategy, Urology, Gastroenterology, and Neurosurgery wards, as well as ENT, had the highest and lowest efficiency rates, respectively. Based on the BCC output-oriented method, Urology, Renal Transplant, Neurosurgery, and Gynecology wards had the highest efficiency in performance, while ENT had the lowest efficiency.
Conclusion: In conclusion, the findings of this study offer a service-oriented nursing supervisor strategy that improves the efficiency of different wards of the hospital.