bluuebunny/crossref_metadata_2025 huggingface dataset:
Andrey Murav’yov’s travel in Abkhazia
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Shcherbakova Marina I.
Published: October 2021

The article is devoted to the little-known travel notes about Abkhazia by Andrey N. Murav’yov, an outstanding Russian spiritual writer, the pioneer of the genre of literary pilgrimage travels, the discoverer of Christian and Orthodox shrines in Russia and abroad for his compatriots and contemporaries. Travel essay “Abkhazia. Pitsunda”, included as a separate chapter in the book “Georgia and Armenia”, was created under the impression of the author’s trip in the spring of 1847 to the Black Sea coast of the Caucasus. It presents genre sketches of the city life of Sukhumi, descriptions of the luxurious southern nature, it gives excursions into the history of the region, and it characterises the features of the economic state. The main part of Andrey Murav’yov’s Black Sea memories concerns Pitsunda. As a deep connoisseur of the history of Christianity, Andrey Murav’yov traced its ancient roots in the land of Abkhazia, where the apostles Simon the Canaanean, Andrew the First- Called, St. John Chrysostom. In detailed descriptions of the ancient churches, the writer recorded their condition; despite the artistic form of the story, they have the value of a reliable historical document that helps to reconstruct many of the losses that occurred under the influence of time.
«Just as if you pay a visit to paradise and forget about everything…» Essay by E. Dyakonova about Abkhazia
Authors:   The Russian State Library, Krutova Marina S.
Published: October 2021

The Department of Manuscripts of the RSL contains a little-known essay “On Black Sea Coast” by Yelizaveta D’yakonova, included in the “Diary of a Russian Woman”. The young female writer presents the information she knows about the history of Abkhazia and the New Athos Monastery named after Simon the Canaanean, she shares her impressions of her stay in these places. The facts from the history of Abkhazia cited in the essay may have been gleaned by her from various publications with which she could get acquainted while living in Abkhazia or already upon her arrival in St. Petersburg. This work is only a part of her notes, written in Abkhazia, as there are still more extensive rough notes, which she probably also wanted to include in her “Diary...”.
As startups no ordenamento jurídico: uma leitura comparada dos ecossistemas de startups na Argentina, no Chile e no Brasil
Authors: Iana Matos Anunciação Ingrid , Andrade Fernandes Gabriela
Published: October 2021

Este artigo tem como objetivo buscar possíveis soluções para os obstáculos legislativos e culturais que as startups enfrentam no Brasil, por meio de uma na        álise teórica e comparada dos institutos jurídicos e costumes empresariais dos ecossistemas jurídicos em que as empresas de caráter inovador argentinas e chilenas estão inseridas. Pretende, também, evidenciar a necessidade de modernização das legislações que influenciam na dinâmica das startups, bem como de estimular o fomento e o auxílio governamental às atividades empresariais inovadoras de pequeno e médio porte no Brasil, além de apresentar os principais conceitos caracterizadores dessas empresas, sua dinâmica e importância no cenário empresarial globalizado.
Cuidar e educar na creche: o planejamento pedagógico e a atuação das auxiliares de classe
Authors: Jesus Livia Karen Figueredo de , Cordeiro Karina de Oliveira Santos
Published: October 2021

O presente artigo tem como objetivo apresentar os resultados de uma pesquisa acadêmica sobre as relações entre professoras e auxiliares de classe da Educação Infantil durante o planejamento pedagógico. O objetivo geral do estudo foi compreender como as auxiliares se veem profissionalmente e que lugar elas ocupam no Centro de Educação Infantil. Para a escrita desse artigo, traremos as discussões de uma das categorias que emergiu no percurso da pesquisa, qual seja: “As auxiliares de classe e o planejamento pedagógico”. O lócus da pesquisa foi um Centro de Educação Infantil público do município de Amargosa – Bahia. Trata-se de uma pesquisa qualitativa, utilizamos como instrumentos metodológicos a entrevista semiestruturada e a observação. Nesse sentido, realizamos o debate acerca da integração do cuidar e do educar, tendo em vista as relações que se estabelecem entre professoras e auxiliares de classe na elaboração do planejamento pedagógico. Identificamos que, em algumas situações durante as entrevistas, as trabalhadoras apontaram a importância da integração, e até conseguiram indicar as possibilidades de ações para a efetivação da indissociabilidade do cuidar e do educar, contudo, em outros momentos da observação, foi possível identificar que de fato havia uma separação. É preciso dizer que a superação não se configura como algo fácil. Mas ela é possível, por meio da reestruturação no que diz respeito à divisão entre as trabalhadoras, reconhecendo que cuidar e educar são atribuições docentes.
Aproximações entre curadoria digital e CAQDAS: uma revisão sistemática de literatura
Authors: Silva Katia Alexandra de Godoi e , Costa António Pedro
Published: October 2021

Este artigo propõe contribuir para a reflexão sobre o processo de curadoria digital, no intuito de discorrer sobre algumas das principais concepções sobre curadoria digital em diferentes contextos, tanto por autores brasileiros quanto estrangeiros, de modo a elucidar e aproximar o tema na organização e gestão de dados em Computer Assisted Qualitative Data Analysis Software (CAQDAS). Para alcançar tal objetivo, esta pesquisa se utilizou de metodologia qualitativa de cunho descritivo, possibilitada por uma revisão sistemática da literatura de trabalhos científicos sobre o tema da curadoria digital, a partir de buscas em uma base de dados acadêmicas (Scopus) e em uma base da literatura cinzenta (Banco de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES). Como resultados, constatou-se que as concepções sobre curadoria digital convergem para diferentes práticas de curadoria de conteúdo, curadoria digital de dados de pesquisa ou eScience e curadoria digital. Também constatou-se que a curadoria digital pode ser aplicada em diferentes contextos, como bases de dados colaborativas, redes sociais, repositórios, gerenciadores de dados qualitativos, preservação do acervo de objetos culturais digitais, além da organização de dados qualitativos em CAQDAS e também como proposta metodológica no processo de ensino.
Pesquisa pós-qualitativa e responsabilidade ética: notas de uma etnografia fantasmática
Authors: Macedo Elizabeth Fernandes de , Silva Paulo de Tássio Borges da
Published: October 2021

Este texto apresenta reflexões metodológicas do grupo de pesquisa “Currículo, cultura e diferença”, cujo foco é a investigação de políticas curriculares e seus efeitos sobre os processos de circulação da diferença. Para tanto, partimos do diálogo com a pesquisa “Paisagens e Fluxos Curriculares Pataxó: processos de hibridização e biopolítica”, que buscou repensar as possibilidades da etnografia na pesquisa pós-estrutural em educação. Rasurando e ressemantizando o itinerário de construção científica da Antropologia com foco na pesquisa cultural, buscamos discutir a potencialidade de etnografias fantasmáticas para a pesquisa pós-qualitativa em educação. Numa abordagem flexionada por perspectivas pós-estrutural e pós-colonial, refletimos sobre a potência da etnografia fantasmática na contrução de um texto autobiofictício que busca responder de forma ética à interpelação da alteridade enquanto somos afetados por fantasmas espectrais. Nesse sentido, buscamos exemplificar como vimos buscando embaralhar as normas de composição de “verdades” e realidades, tratando-as as como fluxos de ficções complexos.
Pressupostos para a elaboração de relato de experiência como conhecimento científico
Authors: Mussi Ricardo Fraklin de Freitas , Flores Fabio Fernandes , Almeida Cláudio Bispo de
Published: October 2021

O presente trabalho aborda os pressupostos para o conhecimento científico, cuja modalidade a ser tematizada é o relato de experiência (RE). Este tipo de texto trata de uma vivência que tem relevância para o meio acadêmico ao compreender fenômenos de possibilidades interventivas da área e auxiliar na formação acadêmica, e também na profissional. O objetivo deste artigo é discutir os pressupostos teóricos e estruturantes para elaboração de manuscritos da modalidade RE como construção de conhecimento. Trata-se de estudo no formato de ensaio acadêmico-científico. O roteiro tem como propósito auxiliar na edificação e organização de estudos desta modalidade, que destaca o uso do embasamento científico e reflexão crítica. O mesmo é composto por quatro tipos de descrição: informativa, referenciada, dialogada e crítica; cada qual com seus elementos e respectiva pergunta facilitadora para a descrição da informação. A proposta apresentada tem a possibilidade de ampliar a compreensão do RE, uma vez que há poucas referências que abordam sobre os elementos para a sua construção; bem como melhorar a produção científica, que por sua vez contribui para o progresso do conhecimento. Enfim, a sistematização dos estudos de RE pode implicar na melhoria das ações profissionais e campo das ciências.
Apresentação do dossiê temático Pesquisa em educação: abordagens em Portugal e Brasil
Authors: Crusoé Nilma Margarida de Castro , Sá Patricia
Published: October 2021

Apresentação do dossiê.
FUTEBOL E RACISMO: ALGUMAS REFLEXÕES NO ÂMBITO DA EDUCAÇÃO FÍSICA ESCOLAR
Authors: Figueredo Marinete da Frota , Cruz Marlon Messias Santana
Published: October 2021

Este escrito desdobrou-se de uma experiência referente à tematização do futebol, realizada com uma turma de oitavo ano do ensino fundamental de uma escola pública da cidade de Guanambi/Bahia. Tem como intento compartilhar algumas reflexões referentes ao racismo e aos enfrentamentos dos (as) negros (as) ao longo da história desse esporte, alavancando, por conseguinte, o debate acerca da necessidade de se combater manifestações racistas e de reconhecer a pluralidade cultural brasileira. As aulas tiveram como base orientadora a Perspectiva Cultural da Educação Física, proposta por Neira e Nunes (2008), e foram desenvolvidas por meio da prática do mapeamento, da ressignificação, do aprofundamento e ampliação, bem como, da avalição de todo o processo de tematização. Ao longo dessas ações, com o intuito de fomentar à turma uma leitura crítica sobre o futebol, foi problematizada a história dessa prática corporal, enfatizando as desigualdades raciais e condutas racistas presentes nas suas tessituras. Os (as) alunos (as) pouco conheciam as desigualdades raciais que atravessam a história do esporte e avaliaram positivamente a tematização. Analisa-se como emergente a inserção das questões étnico-raciais no currículo da Educação Física, pois o trabalho pedagógico deste componente pode contribuir de forma significativa para o combate das disparidades da sociedade.
ESCOLA PÚBLICA, FORMAÇÃO DOCENTE E AS TECNOLOGIAS DIGITAIS NO CONTEXTO DA PANDEMIA
Authors: Félix Carlos Marcelo Cavalheiro
Published: October 2021

Este artigo configura-se um breve estudo de cunho qualitativo, com caráter analítico, tendo aporte na leitura de bibliografias e na análise sociológica inspirada nas percepções de Bauman (2001, 2008a e 2008b). Os teóricos Bazzo & Andreatta-da-Costa (2019), Canário (2005), Kenski (2012), Sancho (2006) e Libâneo (2020) contribuem para o ambiente da discussão tencionando o olhar para a formação docente, tanto inicial quanto continuada, em perspectiva humanizada face as suas ações na e no pós-pandemia. Sua finalidade está em refletir o tema da formação docente confrontada com o uso das ferramentas tecnológicas digitais, mediante o contexto atual da pandemia.  No entanto, entende-se que: a) do ponto de vista do homem líquido-moderno, a educação brasileira se configura na condição de produto para o mercado capitalista, objetificando as suas práticas no tempo-espaço agorista, fluido e liquidado; b) há necessidade de rever as ações pedagógicas, no contexto da pandemia; c) a escola pública brasileira, recebe como desafio formar o corpo docente buscando sensibilizá-lo para o uso das ferramentas tecnológicas digitais; d) considerando que as ações humanizadoras são indispensáveis nas práticas cotidianas da escola pública torna-se pertinente os espaços reflexivos e dialógicos ensejando a continuidade das aprendizagens escolares.
EDUCAÇÃO CRÍTICA E IDEOLOGIZAÇÃO DA EDUCAÇÃO: COLOCANDO OS PINGOS NOS ‘IS’
Authors: Henriques Eduardo
Published: October 2021

Esse artigo discute o lugar do ideário ideológico nas salas de aula brasileiras. Para tanto, principiar-se-á a argumentação no posicionamento adversativo de duas frentes nocionais concernentes à questão: a primeira será a Educação Crítica, entendedora do fazer humano como ideológico, enquanto a segunda é a Ideologização da Educação, defensora da práxis educadora como neutra e neutralizadora. De antemão, clarifica-se essa discussão como fiduciária da Teoria Dialógica do Discurso, defensora das ações humanas como signos e desses como materialidade ideológica. Logo, assumindo essa corrente teórica, recorre-se, ainda, à Freire (2011) para abalizar o lugar da ideologia na experiência escolar, arguindo não só sua presença, mas seus efeitos, pois, o cerne da questão deve ser se a ideologia orientada às escolas promove inclusão e cidadania ou marginalização e violência. Portanto, consoante às epistemologias de Bakhtin (1990) e Volochinov (1988), sobre ideologia, e de Bourdieu (1989) e Saint Martin (2003), acerca da escola, pretende-se desvelar a falácia do Paradigma da Neutralidade e seus nefastos efeitos à formação escolar. Em contrapartida, advogar-se-á uma práxis formativo-crítica e vocacionada à construção coletiva de um estatuto societário cidadão, em oposição às vivências escolares impositivas de modelos normativos obedientes a status quo ratificador de perversas assimetrias sociais.
TRANSTORNO DE PERSONALIDADE BORDERLINE: NARRATIVA DE UMA VIVÊNCIA ACADÊMICA NO ENSINO SUPERIOR
Authors: Nascimento Anália Carina Pereira Lopez , Ferraz Rita de Cássia Souza Nascimento
Published: October 2021

Esta investigação propôs analisar as implicações do Transtorno de Personalidade Borderline no percurso acadêmico de discentes do Ensino Superior, bem como situações de enfrentamento na trajetória formativa. A abordagem qualitativa adotada foi descritiva, na forma de estudo de caso, tendo como foco a vivência acadêmica no Ensino Superior. A participante foi selecionada a partir de um levantamento realizado pelo Núcleo de Acessibilidade e Inclusão de Pessoas com Deficiência (NAIPD/Universidade Estadual do Sudoeste da Bahia) dos discentes que apresentaram laudo comprovando o transtorno e atendidos pelos serviços de assistência estudantil da instituição. Através da entrevista narrativa, a participante, narrou situações significativas da sua trajetória, bem como a sua compreensão como um sujeito Border. A análise dessa narrativa permitiu identificar que as características comportamentais apresentadas corresponderam as de um indivíduo Borderline: estado dissociativo ou de despersonalização, solidão, sinais de ansiedade e transtorno obsessivo compulsivo. Foram identificados, também, como pontos significativos na trajetória acadêmica da discente, a importância do papel do professor no auxílio e no acolhimento a esses alunos. Por fim, o adoecimento psíquico tem seus desafios, mas também suas vitórias: a superação e o desejo de se encontrar e ser alguém que pode contribuir com responsabilidade dentro e fora da universidade.
Consumo de antimicrobianos em unidades de terapia intensiva neonatais: resistência bacteriana x ações de racionalização
Authors: Oliveira Cinara Rejane
Published: October 2021

Os antimicrobianos estão entre os medicamentos mais prescritos nas Unidades de Terapia Intensiva Neonatais (UTIN). Assim, é necessário um maior controle em sua utilização devido principalmente ao favorecimento do aumento da resistência bacterina.  O “Antimicrobial Stewardship Program (ASP)” é um programa de gerenciamento de antimicrobianos que consiste em um conjunto de intervenções coordenadas, com o objetivo de melhorar e medir o uso adequado dos antimicrobianos. No Brasil, a Gerência de Vigilância e Monitoramento em Serviços de Saúde (GVIMS), em conjunto com a Gerência Geral de Tecnologia em Serviços de Saúde (GGTES), e a Agência Nacional de Vigilância Sanitária (ANVISA), adaptando o citado programa à realidade do Brasil, elaborou a Diretriz Nacional para Elaboração de Programa de Gerenciamento do Uso de Antimicrobianos em Serviços de Saúde. Nessa diretriz estão abordadas ações que devem ser implantadas nas unidades de saúde que visam ao uso racional de antimicrobianos. Considerando a necessidade de atenção nesse contexto, esse trabalho irá abordar ações que visem à redução do uso incorreto de antimicrobianos descritas na literatura e que podem ser implantadas no contexto das Unidades de Terapia Intensiva Neonatais.
PatientMatcher: a customizable Python-based open-source tool for matching undiagnosed rare disease patients via the MatchMaker Exchange network
Authors: Rasi Chiara , Nilsson Daniel , Magnusson Måns , Lesko Nicole , Lagerstedt-Robinson Kristina , Wedell Anna , Lindstrand Anna , Wirta Valtteri , Stranneheim Henrik
Published: October 2021

The amount of data available from genomic medicine has revolutionized
the approach to identify the determinants underlying many rare diseases.
The task of confirming a genotype-phenotype causality for a patient
affected with a rare genetic disease is often challenging. In this
context, the establishment of the MatchMaker Exchange (MME) network has
assumed a pivotal role in bridging heterogeneous patient information
stored on different medical and research servers. MME has made it
possible to solve rare disease cases by “matching” the genotypic and
phenotypic characteristics of a patient of interest with patient data
available at other clinical facilities participating in the network.
Here, we present PatientMatcher
(https://github.com/Clinical-Genomics/patientMatcher), an open-source
Python and MongoDB-based software solution developed by Clinical
Genomics facility at the Science for Life Laboratory in Stockholm.
PatientMatcher is designed as a standalone MME server, but can easily
communicate via REST API with external applications managing genetic
analyses and patient data. The MME node is being implemented in clinical
production in collaboration with the Genomic Medicine Center Karolinska
at the Karolinska University Hospital. PatientMatcher is written to
implement the MME API and provides several customizable settings,
including a custom-fit similarity score algorithm and adjustable
matching results notifications.
Application of different combinations of lactic acid, phototrophic bacteria and yeast mixtures in control of seed and seedlings pathogens of tomato and pepper
Authors: Ristic Danijela , Vucurovic Ivan , Aleksic Goran , Nikolic Bogdan , Djurovic Sanja , Starovic Mira
Published: October 2021

Application of three combinations of lactic acid bacteria (Lactobacillus
plantarum, Lactobacillus rhamnosus), phototrophic bacteria (Rhodopseudomonas
palustris) and yeast (Saccharomyces cerevisiae) with sugar cane molasses,
marked as: EM1, EM5 and EM AGRO, against the phytopathogenic fungi of tomato
and pepper: Fusarium oxysporum, Alternaria alternata, Botrytis cinerea,
Colletotrichum sp., Verticilium dahliae and Pythium aphanidermatum was
evaluated in vitro and in vivo. A combination of bacteria and yeast named
EM5 showed the highest mycelium growth inhibition against B. cinerea (38.4%)
in a double agar diffusion test. In a microdilution test, the combination
EM1 showed the highest inhibitory effect on B. cinerea (MIC 1x10-3 ?l/ml),
while EM5 showed a similar inhibitory effect towards F. oxysporum, A.
alternata and Colletotrichum sp. (MIC 10 ?l/ml). The use of EM1 (in
concentrations 10 and 100 ?l/ml) and EM AGRO (10 ?l/ml) is recommended for
tomato seedling protection. ??1 (100 ?l/ml), ??5 and ?? AGRO (10 ?l/ml) are
recommended for pepper seedling protection.
Characteristics of the Gut Microbiota and Metabolism in Patients With Latent Autoimmune Diabetes in Adults: A Case-Control Study
Authors: Fang Yuanyuan , Zhang Chenhong , Shi Hongcai , Wei Wei , Shang Jing , Zheng Ruizhi , Yu Lu , Wang Pingping , Yang Junpeng , Deng Xinru , Zhang Yun , Tang Shasha , Shi Xiaoyang , Liu Yalei , Yang Huihui , Yuan Qian , Zhai Rui , Yuan Huijuan
Published: October 2021

OBJECTIVE

Type
1 and type 2 diabetes are associated with gut dysbiosis. However, the
relationship between the gut microbiota and latent autoimmune diabetes in
adults (LADA), sharing clinical and metabolic features
with classic type 1 and type 2 diabetes, remains unclear. Here, we identified the
characteristics of the gut microbiota and metabolic profiles in patients with LADA
using a multi-omics approach.

RESEARCH
DESIGN AND METHODS

This
age- and sex-matched case-control study included 30 patients with LADA, 31
patients with classic type 1 diabetes, 30 patients with type 2 diabetes, and 29
healthy individuals. The gut microbiota profiles were identified via the 16S
rRNA gene, and fecal and serum metabolites were measured via untargeted liquid chromatography-mass
spectrometry.

RESULTS

LADA
patients had a significantly different structure and composition of the gut
microbiota and their metabolites as well as a severe deficiency of short-chain
fatty acid-producing bacteria. The gut microbiota structure of the LADA patients
was more similar to that of patients with type 1 diabetes who were positive for
GAD antibody. We identified seven serum metabolite modules and eight fecal
metabolite modules that differed between the LADA group and the other groups.

CONCLUSIONS

The characteristic gut microbiota and related metabolites
of patients with LADA are associated with autoantibodies, glucose metabolism,
islet function, and inflammatory factors, which may contribute to the pathogenesis
of LADA. Future longitudinal studies should
explore whether modulating the gut microbiota and related metabolites can alter
the natural course of autoimmune diabetes, in the quest for new therapeutic.
Androgens and Development of Posttransplantation Diabetes Mellitus in Male Kidney Transplant Recipients: A Post Hoc Analysis of a Prospective Study
Authors: Stam Suzanne P. , Sokooti Sara , Eisenga Michele F. , Veen Anna van der , Gomes-Neto Antonio W. , Dijk Peter R. van , Zanden Jelmer J. van , Vos Michel J. , Kema Ido P. , Beek André P. van , Bakker Stephan J. , Investigators TransplantLines
Published: October 2021

Objective. Post-transplantation
Diabetes Mellitus (PTDM) effects up to 30% of all kidney transplant recipients
(KTR). Recent studies in mice found that sufficient androgen levels are
necessary for β-cell health and adequate insulin secretion. This raises the
question whether a similar relationship might be present in KTR. Hence, we hypothesized
that dihydrotestosterone and testosterone are associated with the development
of PTDM in male KTR.

Research
design and Methods. We
conducted a post-hoc analyses of a prospective single-center cohort study
including adult male KTR with a functioning graft ≥1 year post-transplantation.
Androgen levels were assessed by liquid chromatography tandem mass
spectrometry. Development of PTDM was defined according to the American Diabetes
Association’s criteria.

Results. We included 243
male KTR (age 51 ± 14 years), with a median dihydrotestosterone 0.9 [0.7–1.3]
nmol/L and testosterone of 12.1 [9.4–15.8] nmol/L. During 5.3 [3.7–5.8] years
of follow-up, 28 KTR (11.5%) developed PTDM. A clear association was observed
as 15 (19%), 10 (12%), and 3 (4%) male
KTR developed PTDM in the respective tertiles of dihydrotestosterone (P=0.008).
In
Cox regression analyses, both dihydrotestosterone and testosterone as
continuous variables, were inversely associated with the risk to development
PTDM, independent of glucose and HbA1c (HR 0.31; 95%CI[0.16–0.59], P<0.001
and HR 0.32; 95%CI[0.15–0.68], P=0.003 respectively).

Conclusions.
Our results suggest that low androgen levels are a novel potential modifiable risk
factor for the development of PTDM in male KTR.
Prior Glucose-Lowering Medication Use and 30-Day Outcomes Among 64,892 Veterans With Diabetes and COVID-19
Authors: Wander Pandora L. , Lowy Elliott , Beste Lauren A. , Tulloch-Palomino Luis , Korpak Anna , Peterson Alexander C. , Kahn Steven E. , Boyko Edward J.
Published: October 2021

Objective: To identify pre-infection risk
factors for adverse outcomes among Veterans with diabetes mellitus and COVID-19
infection.

Research design and
methods: We identified all Veterans Health Administration
patients with diabetes and ≥1 positive nasal swab for SARS-CoV-2 (March 1, 2020–March
10, 2021) (n=64,892). We examined associations of HbA1c and glucose-lowering medication
use with hospitalization, ICU admission, and mortality at 30 days using
logistic regression models and over 4.4 months of follow-up (range <1–13.1
months) using proportional hazards models.

Results: Compared
to HbA1c <7.0%, HbA1c ≥9.0% was associated with higher odds of
hospitalization, ICU admission and death at 30 days as well as higher risk of
death over 4.4 months (OR 1.27[95%CI 1.19–1.35], 1.28[95%CI 1.15–1.42], 1.30[95%CI
1.17–1.44]; HR 1.22[95%CI 1.12–1.32). Insulin use was associated with higher odds of
hospitalization, ICU admission and death (OR 1.12[95%CI 1.07–1.18], 1.12[95%CI
1.04–1.22], and 1.18[95%CI 1.09–1.27]) and higher risk of death (HR 1.12[95%CI
1.07–1.18]). Sodium-glucose cotransporter 2 inhibitor (SGLT2i), glucagon-like
peptide-1 receptor agonist (GLP1-RA), or angiotensin receptor blocker (ARB) use
were associated with lower odds of hospitalization (OR 0.92[95%CI 0.85–0.99], OR
0.88[95%CI 0.81–0.96], and 0.94[95%CI 0.89–0.99]). Metformin and SGLT2i use
were associated with lower odds and risk of death (OR 0.84[95%CI 0.78–0.91], 0.82[95%CI
0.72–0.94]; HR 0.84[95%CI 0.79–0.89], 0.82[95%CI 0.74–0.92).

Conclusions: Among
Veterans with diabetes and COVID-19, higher HbA1c and insulin use were directly
associated with adverse outcomes, while use of a GLP1-RA, metformin, and SGLT2i
were inversely associated.
Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism
Authors: Li-Gao Ruifang , Hughes David A. , Klinken Jan B. van , Mutsert Renée de , Rosendaal Frits R. , Mook-Kanamori Dennis O. , Timpson Nicholas J , Dijk Ko Willems van
Published: October 2021

Humans
spend the greater part of the day in a postprandial state. However, the genetic
basis of postprandial blood measures is relatively uncharted territory. We set
out to examine the genetics of variation in concentrations of postprandial metabolites
(t=150 min) in response to a liquid mixed meal through genome-wide association
studies (GWAS) performed in the Netherlands Epidemiology of Obesity study
(N=5,705). The metabolite response GWAS identified an association between
glucose change and rs10830963:G in the melatonin receptor 1B (beta (SE): -0.23
(0.03), P-value: 2.15×10-19). In addition, ANKRD55 locus led by rs458741:C showed strong associations to
extremely large VLDL particle (XXLVLDL) response (with XXLVLDLC: beta (SE):
0.17 (0.03) P-value: 5.76×10-10 and with XXLVLDLCE: beta (SE): 0.17
(0.03), P-value: 9.74×10-10), which also revealed strong
associations to body composition and diabetes in the UK Biobank (p-values<5×10-8).
Furthermore, the associations between XXLVLDL response and insulinogenic index,
HOMA-β, ISI matsuda index and HbA1c in the NEO study further implied the role
of chylomicron synthesis in diabetes (with FDR corrected q-value<0.05). To
conclude, genetic studies of
metabolomics change after a liquid meal illuminate novel pathways for glucose
and lipid metabolism. Further studies are warranted to corroborate biological
pathways of ANKRD55 locus underlying
diabetes.
Empagliflozin Treatment is Associated With Improvements in Cardiac Energetics and Function and Reductions in Myocardial Cellular Volume in Patients With Type 2 Diabetes
Authors: Thirunavukarasu Sharmaine , Jex Nicholas , Chowdhary Amrit , Hassan Imtiaz Ul , Straw Sam , Craven T.P. , Gorecka M , Broadbent David , Swoboda Peter , Witte Klaus K , Cubbon Richard M , Xue Hui , Kellman Peter , Greenwood John P. , Plein Sven , Levelt Eylem
Published: October 2021

Sodium–glucose-cotransporter-2
(SGLT2) inhibitors reduce the risk of major
adverse CV events and hospitalization for heart failure in type 2 diabetes
(T2D) patients. Utilising cardiovascular
magnetic resonance imaging (CMR) and 31phosphorus magnetic resonance
spectroscopy(31P-MRS) in a longitudinal cohort study, we aimed to
investigate the effects of the selective SGLT2i empagliflozin on myocardial
energetics, cellular volume, function and perfusion. Eighteen T2D
patients underwent CMR and 31P-MRS scans before and after
twelve-week empagliflozin treatment. Plasma N-terminal pro hormone B-type natriuretic peptide (NT-proBNP) levels were measured. Ten
volunteers with normal glycaemic control underwent an identical scan protocol on a single visit. Empagliflozin treatment was associated with significant
improvements in PCr/ATP ratio (1.52 to 1.76, p=0.009). This was accompanied by
a 7% absolute increase in the mean LVEF (p=0.001), 3% absolute increase in the mean global longitudinal strain (p=0.01),
8 ml/m2 absolute reduction in the mean myocardial cell volume (p=0.04) and
61% relative reduction in the mean NT-proBNP (p=0.05)
from baseline measurements. No significant change in myocardial blood flow or
diastolic strain was detected. Empagliflozin thus ameliorates the ‘cardiac energy-deficient’
state, regresses adverse myocardial cellular remodelling, and improves cardiac function, offering therapeutic opportunities to prevent or modulate heart failure
in T2D.
Odonate ethodiversity as a bioindicator of anthropogenic impact
Authors: Guillermo-Ferreira Rhainer , Juen Leandro
Published: October 2021

The increasing use of dragonflies and damselflies as models in studies on biodiversity in the last decades has unraveled several features of natural processes and mechanisms for species conservation. Nevertheless, biodiversity is a polysemic concept that resolves multiple dimensions that, together, enroll what we observe as species and lineages diversity. One of these dimensions is Ethodiversity, which may represent the individual diversity of behavioral traits and higher organization levels. Hence, measures of Ethodiversity may be used as indicator tools to measure such dimensions of biodiversity. However, we still lack methods and protocols to measure this diversity. Therefore, here we addressed whether damselfly behaviors may act as indicators of environmental impacts. We collected behavioral data of 120 males in two sites, one in an ecological reserve and another in an impacted habitat. Our results show differences in behavioral syndromes and behavioral integrity when comparing populations in impacted and conserved environments. In conclusion, we hope that these results stimulate future endeavors to create a methodological framework to assess behavioral diversity.
Multigenerational Health Research using Population-Based Linked Databases: An International Review
Authors: Hamm Naomi C. , Hamad Amani F , Wall-Wieler Elizabeth , Roos Leslie L , Plana-Ripoll Oleguer , Lix Lisa M
Published: October 2021

Family health history is a well-established risk factor for many health conditions but the systematic collection of health histories, particularly for multiple generations and multiple family members, can be challenging. Routinely-collected electronic databases in a select number of sites worldwide offer a powerful tool to conduct multigenerational health research for entire populations. At these sites, administrative and healthcare records are used to construct familial relationships and objectively-measured health histories. We review and synthesize published literature to compare the attributes of routinely-collected, linked databases for three European sites (Denmark, Norway, Sweden) and three non-European sites (Canadian province of Manitoba, Taiwan, Australian state of Western Australia) with the capability to conduct population-based multigenerational health research. Our review found that European sites primarily identified family structures using population registries, whereas non-European sites used health insurance registries (Manitoba and Taiwan) or linked data from multiple sources (Western Australia). Information on familial status was reported to be available as early as 1947 (Sweden); Taiwan had the fewest years of data available (1995 onwards). All centres reported near complete coverage of familial relationships for their population catchment regions. Challenges in working with these data include differentiating biological and legal relationships, establishing accurate familial linkages over time, and accurately identifying health conditions. This review provides important insights about the benefits and challenges of using routinely-collected, population-based linked databases for conducting population-based multigenerational health research, and identifies opportunities for future research within and across the data-intensive environments at these six sites.
Significant Role of Procalcitonin and Proinflammatory Markers in Diabetic Foot Ulcer Infections
Authors: Gahlot Dr. Ghanshyam , Ram Dr. Poonma , Parmar Dr. Dinesh , Garg Dr. Manoj , Hundekar Dr. Prakash , Aseri Dr. R. K. , Mansuriya Dr. B. L. , Kumar Dr. Surendra
Published: October 2021

Background: Procalcitonin (PCT), an amino acid protein precursor of calcitonin hormone released by thyroid C cells or other body cells, can be used as a marker for diagnosing infection. PCT has a suggestive role in diagnosing diabetic foot infection alone or in combination with other markers of infection. Aim: We aimed to evaluate the roles of interleukin-6 (IL-6), CRP, and PCT levels in the differential diagnosis of the patients with infected diabetic foot ulcer (IDFU) and non-infected diabetic foot ulcer (NIDFU) and to compare those with C-reactive protein (CRP), white blood cell (WBC), and erythrocyte sedimentation rate (ESR). Methods: A total of 95 subjects with DFU and NIDFU were enrolled. WBC count, ESR, CRP, and PCT were done for all subjects at admission after obtaining informed consent. Patients over 18 years with a diagnosis of type 2 diabetes mellitus and DFU who were followed up in our hospital were included in the study. In addition to this patient group, patients with diabetes but without DFU were determined as the control group. Results: Twenty nine patients with IDFU, 29 patients with NIDFU, and 43 patients as the control group were included in the study. Fifty-six point three percent of the patients who participated in the study were males, and the mean age was 62.87 ± 10.99 years. WBC, ESR, CRP, and IL-6 levels of the cases with IDFU were determined to be significantly higher compared to the cases in NIDFU (p <0.001). The area under the ROC curve (AUROC) value was highest for CRP (p <0.001), and the best cut-oﬀ value for CRP was 36 m/L. The best cut-oﬀ values for IL-6, ESR, and WBC were 109.4 pg/mL, 53 mm/h, and 13.7 (103 μ/L), respectively. Conclusion: Serum PCT levels were not found to be eﬀective in the discrimination of IDFU and NIDFU. Serum IL-6 level seems to be one promising inﬂammatory markers in the discrimination of IDFU. Based on our results, we conclude that PCT has a valuable role in diagnosing infection in DFUs.
Analiz prichin rannej neonatal'noj smertnosti v Rossijskoj Federacii v 2020 g. (god pandemii COVID-19)
Authors: Туманова У. Н. , Щеголев А. И. , Чаусов А. А. , Шувалова М. П.
Published: October 2021

V marte 2020 g. Vsemirnaya organizaciya zdravoohraneniya ob"yavila o pandemii COVID-19. Cel'yu raboty bylo provesti sravnitel'nyj analiz prichin i pokazatelej rannej neonatal'noj smertnosti v Rossijskoj Federacii (RF) v 2020 i 2019 g. s pomoshch'yu statisticheskih form A-05 Rosstata za 2019 i 2020 g., sostavlennyh na osnovanii zapisej v medicinskih svidetel'stvah o perinatal'noj smerti i otnosyashchihsya k sluchayam rannej neonatal'noj smerti. V 2020 g. v RF zaregistrirovano umen'shenie absolyutnogo chisla zhivyh novorozhdennyh na 7,6% po sravneniyu s dannymi 2019 g. Pokazatel' rannej neonatal'noj smertnosti v 2020 g. (1,59‰) snizilsya na 4,4% po sravneniyu s pokazatelem 2019 g. (1,67‰). Odnako v YUzhnom i Dal'nevostochnom federal'nyh okrugah pokazateli rannej neonatal'noj smertnosti povysilis' na 20,5 i 6,1% sootvetstvenno. V celom po RF naibolee chastoj prichinoj rannej neonatal'noj smertnosti byli zabolevaniya, vhodyashchie v gruppu respiratornyh narushenij, sostavivshie 37,3 i 40,2% ot obshchego chisla umershih novorozhdennyh v 2019 i 2020 g. sootvetstvenno. Dolya vrozhdennogo sepsisa kak pervonachal'noj prichiny smerti sostavila 43,6 i 46,6% v gruppe infekcionnyh zabolevanij i 7,3 i 7,9% ot vsekh umershih novorozhdennyh v 2019 i 2020 g. sootvetstvenno. Ustanovleno uvelichenie doli zabolevanij, vhodyashchih v gruppu respiratornyh narushenij, vklyuchaya vrozhdennuyu pnevmoniyu i tak nazyvaemye drugie respiratornye sostoyaniya, a takzhe infekcij, v tom chisle vrozhdennogo sepsisa, chto otrazhaet negativnoe pryamoe i oposredovannoe vliyanie SARS-CoV-2-inficirovaniya u beremennyh i u novorozhdennyh.
emystifying Violence in Stanley Kubrick’s Movie, A Clockwork Orange: A Zizekian Perspective
Authors: Babujee Bibin John
Published: October 2021

The Merriam-Webster dictionary defines violence as the “use of physical force so as to injure, abuse, damage, or destroy”. In this regard, violence is a dominating theme in the movie, A Clockwork Orange. Removing it from the equation, the movie loses its soul. The movie is too violent in its treatment and for the very reason, invited a lot of criticism and animosity from various quarters. It was highly controversial at the time of its release for its unusually explicit demonstrations of sex and violence. What exactly could be the purpose of this “ultra-violence”? Does it necessarily have a purpose and motive? A brief overview of the movie must be helpful in better understanding the various dimensions of violence in it.
Divorce in post-epidemic society: reasons and consequences
Authors: Besschetnova Oksana V. , Fomina Svetlana N. , Shimanovskaya Yanina V. , Sizikova Valeriya V. , Karpunina Anastasia V. , Konstantinova Natalia P.
Published: October 2021

The article is devoted to the study of the main trends in divorce rates in three subjects of the Russian Federation (Moscow, Saratov and Chelyabinsk regions) over the last decade, considering a number of socio-demographic indicators: gender, age, marriage’s duration, number of children and place of residence. The main tools for collecting data are the method of statistical analysis of marital and family indicators in studied regions for the period from 2011 to 2019; secondary analysis of the research results of domestic and foreign scientists and a survey which was attended by persons aged 18-69 (n = 928). The sample is stratified by sex, age, place of residence. The study found that the initiator of divorce in most cases is a woman. The main reasons for divorce in all studied subjects of Russia are the violation of interpersonal relations, economic and social. The pandemic of COVID-19 has had a negative impact on marriage and family relations, aggravating socio-demographic problems, both in Russia and in most countries of the world.
Plasticizing Properties Improvement of Poly (4-Vinylpyridine)/Clay Composites: Effect of Composition and Clay Nature
Authors: Dergal Fayçal , Lerari Djahida , Bachari Khaldoun
Published: October 2021

A significant number of investigations have been reported on the elaboration and characterization of Polymer/Clays composites, via different methods. In our work, new composites materials were successfully prepared by in-situ polymerization of 4-vinylpyridine (4VP), in presence of two different types of Algerian modified clays (Maghnia and Mostaganem), noted (BC) and (MC), respectively. Different percentage clays (1 wt%, 3 wt% and 5 wt%) have been used. The differential scanning calorimetry analysis reveals the variation of glass transition temperature (Tg) of the copolymer in the composite materials. We show a decrease glass transition temperature (Tg) from 147°C to 131°C for P4VP-BC and from 147°C to 124°C for P4VP-MC according to the increase percentage of clays. Thermogravimetric analysis (TGA) shows good stability of composite materials at high temperature. Fourier Transformed Infrared (FTIR), Scanning Electron Microscopy coupled with Energy dispersive X-Ray Spectroscopy (SEM-EDX) and 1H NMR spectroscopy are used to show the presence of the clays in the materials.
Current and novel pharmacological therapeutic approaches in Post-Traumatic Stress Disorder. A brief review
Authors: Rusz Carmen-Maria , Jîtcă George , Miklos Amalia , Bătrînu Mădălina-Georgiana , Ősz Bianca Eugenia , Imre Silvia
Published: October 2021

Objective: Although not highly prevalent among the general population, post-traumatic stress disorder is a serious psychiatric condition, associated with co-morbidities, mortality and high suicide rates. Currently, there are few approved pharmacological therapies, which count as second-line, augmented to psychotherapy. Studies from the literature emphasize the need for novel treatment options, due to high relapse rates and patients that do not achieve remission. This study provides an overview over the pharmacological treatment of post-traumatic stress disorder, from a neurobiological perspective.

Methods: A systematic research has been conducted through PubMed, PLOS one, Cochrane library and Google Scholar databases.

Results: The neurobiological mechanisms which underlies the symptomatology are not fully elucidated. In the present, some theories involved in the onset/ manifestation are formulated (serotonergic, noradrenergic, glutamatergic, GABA-ergic, endocannabinoid) and the current therapy aims to modulate these neurotransmissions. In light of the studies along the years, a line should be drawn between the drugs acting on reducing the anxiety only and those that exhibit dual effect i.e. reducing the anxiety and affecting the memory reconsolidation processes. Although labelled as recreational drugs rather than compounds with intended therapeutic effects, cannabidiol and 3,4-methylenedioximethamphetamine appear to be the most promising from the perspective of efficacy and benefit-risk ratio.

Conclusion: Preclinical studies come with acceptable results, yet clinical trials are controversial and heterogeneous, given the small population size. Given the seriousness of post-traumatic stress disorder, the attempts to find effective and safe treatment in a context that lacks appropriate therapeutic approaches should be encouraged.
Evaluation of antibacterial and antifungal properties of selected mouthwashes: in vitro studies
Authors: Olejnik Ewa , Biernasiuk Anna , Malm Anna , Szymanska Jolanta
Published: October 2021

Introduction. Mouthwashes should include antimicrobial compounds to inhibit microorganism multiplication, thus the formation and development of dental plaque.

Aim. The aim of the study was to evaluate the antibacterial and antifungal effectiveness of mouthwashes depending on their active ingredients.

Material and methods. In the study, the effect of antibacterial and antifungal properties of mouthwashes on reference bacterial and yeast-like fungi strains was examined. The first type of the assessed mouthwashes contained only sodium fluoride or sodium fluoride and amine fluoride as active ingredients, while the second type contained sodium fluoride and cetylpyridinium chloride.

In the study, a well diffusion method was used to test microorganisms constituting natural or pathogenic microflora of oral mucosa. The used reference microorganisms came from the ATCC: L. acidophilus ATCC 4356, Lactobacillus rhamnosus ATCC 53103, S. mutans ATCC 25175, and Candida yeasts: C. albicans ATCC 2091, C. albicans ATCC 10231, Candida parapsilosis ATCC 22019, Candida glabrata ATCC 90030, Candida krusei ATCC 14243.

Results. The mouthwashes containing sodium fluoride and cetylpyridinium chloride showed an inhibitory effect against a greater number of reference strains used in the study than did mouthwashes that contained only sodium fluoride (or sodium fluoride and amine fluoride) as active ingredients. Against the four reference strains of Candida genus, the mouthwashes with an inorganic and organic fluoride compound showed no or minimum inhibitory effect or were much less effective than the mouthwashes that also contained cetylpyridinium chloride.

Conclusion. Mouthwashes containing multiple ingredients with different antimicrobial mechanisms show synergistic action against the bacterial and fungal microflora responsible for the accumulation of dental plague.
G-tridiagonal majorization on M
n,m
Authors: Mohammadhasani Ahmad , Sayyari Yamin , Sabzvari Mahdi
Published: October 2021

For X, Y ∈ M
n,m
, it is said that X is g-tridiagonal majorized by Y (and it is denoted by X ≺gt Y) if there exists a tridiagonal g-doubly stochastic matrix A such that X = AY. In this paper, the linear preservers and strong linear preservers of ≺gt
are characterized on M
n,m
.
A non-linear discrete-time dynamical system related to epidemic SISI model
Authors: Shoyimardonov Sobirjon K.
Published: October 2021

We consider SISI epidemic model with discrete-time. The crucial point of this model is that an individual can be infected twice. This non-linear evolution operator depends on seven parameters and we assume that the population size under consideration is constant, so death rate is the same with birth rate per unit time. Reducing to quadratic stochastic operator (QSO) we study the dynamical system of the SISI model.
Lime kilns as an element of the post-industrial cultural landscape of the Silesian Upland, Poland
Authors: Hibszer Adam
Published: October 2021

In the Silesian Upland in southern Poland there are many objects related to previous economic activities, mainly from the mining of minerals occurring in a geological basis. In Mikołów Mokre there is the largest group of closed lime kilns in Poland. They constitute a material trace of the quicklime production industry for the construction industry, which operated in this area for almost 200 years. These closed and decaying post-industrial objects are closely related to the presence of limestone and dolomite in the substrate rocks that were obtained from nearby quarries. The aim of the article was to present the current state of these lime kilns and to assess the possibility of using them for tourism purposes. Currently, only two lime kilns are components of the educational trail of the Silesian Botanical Garden established in 2003. Using the example of the Mikołów lime kilns, the opportunities and possibilities for changing the industrial function of these objects to a tourist function are outlined.
Corrosion behaviour of the NiTiX (X = Si, Mg, Al) alloy prepared by self-propagating high-temperature synthesis
Authors: Alferi D. , Hybášek V. , Novák P. , Fojt J.
Published: October 2021

The NiTi alloys are used in the biomaterial field, because of their shape memory, superelasticity, and good corrosion resistance. The influence of alloying elements on the corrosion behaviour of NiTi was studied in this research. Samples were made by the self-propagating high-temperature synthesis method, milled, and then sintered by the spark plasma sintering method. Si, Mg, and Al were used as alloying elements always in 5 wt.%. Studied materials were compared with reference cast NiTi. Polarization resistance was measured after 1 and 12 hours of stabilization in phosphate-buffered saline. It was found out that alloying elements do not have a clear effect on polarization resistance. Si increased Rp and on the other hand, Al decreased it. Measurement of cyclic potentiodynamic polarization in PBS was conducted, too. All studied samples showed signs of localized corrosion. Corrosion was probably initiated in pores, which are presented on the surface due to used manufacturing technology.