bluuebunny/crossref_metadata_2025 huggingface dataset:
Modulation of Renal Insulin Signaling Pathway and Antioxidant Enzymes with Streptozotocin-Induced Diabetes: Effects of Resveratrol
Authors: Sadi Gökhan , Şahin Gamze , Bostanci Aykut
Published: December 2018

Background and objectives: Diabetes mellitus is a disease of insulin deficiency or its inability of usage by the target tissues leading to impairment of carbohydrate, lipid, and protein metabolisms. Resveratrol, having robust anti-inflammatory and anti-oxidant properties, has a high potential to treat or prevent the pathogenesis of diseases. This study was conducted to reveal the relationship between diabetes-induced oxidative stress and tissue inflammation with changes in main enzymatic antioxidants (cat, sod, gpx, and gst) and the components of the insulin signaling pathway (insulin Rβ, irs-1, pi3k, akt, mtor) in kidney tissues. Additionally, the effects of resveratrol on these parameters were evaluated. Materials and Methods: Male Wistar rats were randomly divided into four groups; (1) control/vehicle; (2) control/20 mg/kg resveratrol; (3) diabetic/vehicle; (4) diabetic/20 mg/kg resveratrol. Gene and protein expressions of antioxidant enzymes and insulin signaling elements were evaluated in renal tissues. Results: Downregulation of antioxidant enzymes’ gene expression in the kidney tissues of diabetic rats was demonstrated and this situation was devoted partially to the reduced gene expression of nfκb. Moreover, the components of renal insulin signaling elements were upregulated at both gene and protein expression levels in diabetic rats, and resveratrol treatment decreased this sensitization towards the control state. Conclusion: Resveratrol partially improved diabetes-induced renal oxidative stress and inflammation due to healing action on renal antioxidant enzymes and insulin signaling pathway components.
Hardness Prediction in Hot Stamping Process by Local Blank Heating Based on Quench Factor Analysis
Authors: Kim Jae-Hong , Ko Dae-Cheol , Lee Seon-Bong , Kim Byung-Min
Published: December 2018

Recently, the hot stamping process using local blank heating has been widely used to manufacture lightweight and crashworthy automotive parts. However, the hardness prediction of hot stamped parts produced using local blank heating is difficult because it involves many process variables, such as the heating temperature, heating time, and cooling rate. The purpose of this study was to predict the hardness of hot stamped parts fabricated using local blank heating based on quench factor analysis (QFA). The volume fraction of austenite was measured to consider the phase transformation in the heating stage, and it was expressed by the Johnson–Mehl–Avrami–Kolmogorov (JMAK) equation. Additionally, a dilatometry test was performed to measure the hardness according to the cooling rates, which was used to determine the material constants for QFA. Finite-element simulation was performed to predict the temperature histories during the hot stamping process and the results were used to predict the hardness according to QFA with the JMAK equation. A hot stamping experiment with local blank heating equipment was performed, and the predicted and experimental results were compared for verification of the proposed hardness prediction method.
Random Forest Analysis of Untargeted Metabolomics Data Suggests Increased Use of Omega Fatty Acid Oxidation Pathway in Drosophila Melanogaster Larvae Fed a Medium Chain Fatty Acid Rich High-Fat Diet
Authors: Oza Vishal , Aicher Joseph , Reed Laura
Published: December 2018

Obesity is a complex disease, shaped by both genetic and environmental factors such as diet. In this study, we use untargeted metabolomics and Drosophila melanogaster to model how diet and genotype shape the metabolome of obese phenotypes. We used 16 distinct outbred genotypes of Drosophila larvae raised on normal (ND) and high-fat (HFD) diets, to produce three distinct phenotypic classes; genotypes that stored more triglycerides on a ND relative to the HFD, genotypes that stored more triglycerides on a HFD relative to ND, and genotypes that showed no change in triglyceride storage on either of the two diets. Using untargeted metabolomics we characterized 350 metabolites: 270 with definitive chemical IDs and 80 that were chemically unidentified. Using random forests, we determined metabolites that were important in discriminating between the HFD and ND larvae as well as between the triglyceride phenotypic classes. We found that flies fed on a HFD showed evidence of an increased use of omega fatty acid oxidation pathway, an alternative to the more commonly used beta fatty acid oxidation pathway. Additionally, we observed no correlation between the triglyceride storage phenotype and free fatty acid levels (laurate, caprate, caprylate, caproate), indicating that the distinct metabolic profile of fatty acids in high-fat diet fed Drosophila larvae does not propagate into triglyceride storage differences. However, dipeptides did show moderate differences between the phenotypic classes. We fit Gaussian graphical models (GGMs) of the metabolic profiles for HFD and ND flies to characterize changes in metabolic network structure between the two diets, finding the HFD to have a greater number of edges indicating that metabolome varies more across samples on a HFD. Taken together, these results show that, in the context of obesity, metabolomic profiles under distinct dietary conditions may not be reliable predictors of phenotypic outcomes in a genetically diverse population.
A Study on Parametric Amplification in a Piezoelectric MEMS Device
Authors: Gonzalez Miguel , Lee Yoonseok
Published: December 2018

In various applications, damping from the surrounding fluid severely degrades the performance of micro-electro-mechanical systems (MEMS). In this paper, mechanical amplification through parametric resonance was investigated in a piezoelectrically actuated MEMS to overcome the effects of damping. The device was fabricated using the PiezoMUMPS process, which is based on a Silicon-on-Insulator (SOI) process with an additional aluminum nitride (AlN) layer. Here, a double-clamped cantilever beam with a concentrated mass at the center was excited at its first resonance mode (out-of-plane motion) in air and at atmospheric conditions. A parametric signal modulating the stiffness of the beam was added at twice the frequency of the excitation signal, which was swept through the resonance frequency of the mode. The displacement at the center of the device was detected optically. A four-fold increase in the quality-factor, Q, of the resonator was obtained at the highest values in amplitude used for the parametric excitation. The spring modulation constant was obtained from the effective quality-factor, Q e f f , versus parametric excitation voltage curve. This study demonstrates that through these methods, significant improvements in performance of MEMS in fluids can be obtained, even for devices fabricated using standard commercial processes.
The Surface Integrity of Titanium Alloy When Using Micro-Textured Ball-End Milling Cutters
Authors: Yang Shucai , Yu Song , He Chunsheng
Published: December 2018

Processing certain kinds of micro-textures onto the surface of tools can improve their wear resistance, reduce the friction between them and machined surfaces, prolong their service life and improve their processing efficiency. When milling titanium alloy with ball-end milling cutters, the cutting force and the cutting heat causes plastic deformation and a concentration of stress on workpiece surfaces, damaging their surface integrity. In this paper, we report on a test involving the milling of titanium alloy, where a micro-texture was placed onto the front of a ball-end cutter and the surface roughness and work hardening of the machined surface were studied. The orthogonal experiment was designed around changes in the diameter of the micro-texture, its depth, the spacing between individual micro-pits, and its distance from the cutting edge. Data from the experiment was then used to assess the influence changes in the micro-texture parameters had upon the roughness and hardening of the surface. The data was processed and analyzed by using regression analysis and a prediction model for surface roughness and work hardening was established. The reliability of the model was then verified. The contents of this paper provide a theoretical basis for improving the cutting performance and the surface machining quality of cemented carbide tools.
Silver Nanowires Inks for Flexible Circuit on Photographic Paper Substrate
Authors: Yang Xing , Du Dexi , Wang Yuehui , Zhao Yuzhen
Published: December 2018

Silver nanowires (AgNWs) have inspired many research interests due to their better properties in optical, electric, and flexible applications. One such exploitable use is as the electrical conductive fillers for print electronics. In this paper, AgNWs with mean a diameter of 80 nm and mean length of 13.49 μm were synthesized using the polyol solvothermal method. A sonication-induced scission process was used to obtain AgNWs with a length range of 7.64–11.21 μm. Further AgNWs inks were prepared with the as-synthesized AgNWs as conductive fillers in anhydrous ethanol. The conductive inks were coated on resin coated photographic paper substrate using the knife coating process and dried at room temperature. The effects of the number of layers of AgNWs coating, the concentration of AgNWs, and the length of AgNWs on the microstructure and electrical properties of samples were investigated by scanning electron microscopy and using the four-point probe method. The results show that the conductivity of the AgNWs coating increases with the increase in the number of layers in the AgNWs coating, concentration and length of the AgNWs.
Research on In-Flight Alignment for Micro Inertial Navigation System Based on Changing Acceleration using Exponential Function
Authors: Xu Yun , Zhou Tong
Published: December 2018

In order to guarantee the stable flight of a guided projectile, it is difficult to realize in-flight alignment for the micro inertial navigation system (MINS) during its short flight time. In this paper, a method based on changing acceleration using exponential function is proposed. First, double-vector observations were derived. Then the initial attitude for the guided projectiles was estimated by the regressive quaternion estimation (QUEST) algorithm. Further, the estimated errors were analyzed, and the reason for using the changing acceleration for the in-flight alignment was explained. A simulation and semi-physical experiment was performed to show the effectiveness of the proposed method. The results showed that the initial attitude error for the rolling angle was about 0.35°, the pitch angle was about 0.1° and the heading angle was about 0.6°, in which the initial shooting angle was between 15° and 55°. In future studies, the field experiments will be carried out to test the stability of the proposed in-flight alignment for guided projectiles.
The Study on Numerical Simulation and Experiments of Four Product Hydrocyclone with Double Vortex Finders
Authors: Zhang Yuekan , Liu Peikun , Jiang Lanyue , Yang Xinghua
Published: December 2018

A hydrocyclone is an instrument that can effectively separate multi-phase mixtures of particles with different densities or sizes based on centrifugal sedimentation principles. However, conventional hydrocyclones lead to two products only, resulting in an over-wide particle size range that does not meet the requirements of subsequent operations. In this article, a two-stage series, a four product hydrocyclone is proposed. The first stage hydrocyclone is designed to be a coaxial double overflow pipe: under the effect of separation, fine particles are discharged from the internal overflow pipe, while medium-size particles are discharged from external overflow pipe before entering the second stage hydrocyclone for fine sedimentation. In other words, one-stage grading leads to four products, including the first stage underflow, the first stage overflow, the second stage underflow, and the second stage overflow. The effects of structural parameters and operational parameters on flow field distribution in hydrocyclone were investigated via a study of flow field distribution in multi-product hydrocyclones using numerical simulations. The application of four product hydrocyclone in iron recovery shows that the grade and recovery of iron concentrate exceed 65.08% and 86.14%, respectively. This study provides references for understanding the flow field distribution in hydrocyclones and development of multi-product grading instrument in terms of both theory and industrial applications.
Phytosterol Composition of Arachis hypogaea Seeds from Different Maturity Classes
Authors: Zhou Wenxu , Branch William D. , Gilliam Lissa , Marshall Julie A.
Published: December 2018

The seeds of cultivated peanut, Arachis hypogaea, are an agronomically important crop produced for human nutrition, oilseed and feed stock. Peanut seed is the single most expensive variable input cost and thus producers require seed with excellent performance in terms of germination efficiency. During the maturation process, triglycerides are stored in oil bodies as an energy resource during germination and seedling development. The stability of oil body membranes is essential for nutrient mobilization during germination. This study focused on evaluating the phytosterol composition in seed components including the kernel, embryo (heart), and seed coat or skin. Samples of different maturity classes were analyzed for macronutrient and phytosterol content. The three biosynthetic end products in the phytosterol pathway, β-sitosterol, campesterol and stigmasterol, comprised 82.29%, 86.39% and 94.25% of seed hearts, kernels and seed coats, respectively. Stigmasterol concentration was highest in the seed kernel, providing an excellent source of this sterol known to have beneficial effects on human health. Peanut hearts contained the highest concentration of sterols by mass, potentially providing protection and resources for the developing seedling. The amount of α-tocopherol increases in peanut hearts during the maturation process, providing protection from temperature stress, as well as stability required for seedling vigor. These results suggest that phytosterols may play a significant role in the performance of seeds, and provide a possible explanation for the poor germination efficiency of immature seeds.
IL-6 in Osteoarthritis: Effects of Pine Stilbenoids
Authors: Laavola Mirka , Leppänen Tiina , Hämäläinen Mari , Vuolteenaho Katriina , Moilanen Teemu , Nieminen Riina , Moilanen Eeva
Published: December 2018

Interleukin-6 (IL-6) is involved in the pathogenesis of various inflammatory diseases, like rheumatoid arthritis (RA). In the present study, we investigated the role of IL-6 in osteoarthritis (OA) patients and the effects of the stilbenoids monomethyl pinosylvin and pinosylvin on the expression of the cartilage matrix components aggrecan and collagen II and the inflammatory cytokine IL-6 in human OA chondrocytes. Synovial fluid and plasma samples were obtained from 100 patients with severe OA [BMI 29.7 (8.3) kg/m2, age 72 (14) years, median (IQR); 62/38 females/males] undergoing total knee replacement surgery. IL-6 and matrix metalloproteinase (MMP) concentrations in synovial fluid and plasma were measured by immunoassay. The effects of pinosylvin on the expression of IL-6, aggrecan, and collagen II were studied in primary cultures of human OA chondrocytes. IL-6 levels in synovial fluid from OA patients [119.8 (193.5) pg/mL, median (IQR)] were significantly increased as compared to the plasma levels [3.1 (2.7) pg/mL, median (IQR)] and IL-6 levels in synovial fluid were associated with MMPs and radiographic disease severity. Natural stilbenoids monomethyl pinosylvin and pinosylvin increased aggrecan expression and suppressed IL-6 production in OA chondrocytes. The results propose that IL-6 is produced within OA joints and has an important role in the pathogenesis of OA. Stilbenoid compounds monomethyl pinosylvin and pinosylvin appeared to have disease-modifying potential in OA chondrocytes.
Characterization of Purified Red Cabbage Anthocyanins: Improvement in HPLC Separation and Protective Effect against H2O2-Induced Oxidative Stress in HepG2 Cells
Authors: Fang Sheng , Lin Fubin , Qu Daofeng , Liang Xianrui , Wang Liping
Published: December 2018

In this study, the chemical profiles and antioxidant activities of red cabbage anthocyanin (RCA)-enriched extract are evaluated. The effects of column temperature on the HPLC resolution of the RCAs are studied. The HPLC resolutions became better as the column temperature increased from 20 °C–45 °C. An optimized HPLC condition was achieved at 45 °C and used for the quantification and qualification of the RCAs. The anthocyanins in the enriched powder are all derivatives of cyanidin (268 ± 2 μg/mg), mainly with 19% nonacylated, 51% monoacylated, and 31% diacylated structures with ferulic, sinapic, p-coumaric, and caffeic acids characterized by HPLC-MS. The RCA extracts markedly reduced intracellular oxidative stress production by H2O2 on HepG2 cells and consequently ameliorated cell apoptosis and improved viability. The analytical method and cellular antioxidant activity demonstration of the RCAs will greatly facilitate their functional applications.
Edible Chitosan Films and Their Nanosized Counterparts Exhibit Antimicrobial Activity and Enhanced Mechanical and Barrier Properties
Authors: Gomes Laidson P. , Souza Hiléia K. S. , Campiña José M. , Andrade Cristina T. , Silva António F. , Gonçalves Maria P. , Paschoalin Vania M. Flosi
Published: December 2018

Chitosan and chitosan-nanoparticles were combined to prepare biobased and unplasticized film blends displaying antimicrobial activity. Nanosized chitosans obtained by sonication for 5, 15, or 30 min were combined with chitosan at 3:7, 1:1, and 7:3 ratios, in order to adjust blend film mechanical properties and permeability. The incorporation of nanosized chitosans led to improvements in the interfacial interaction with chitosan microfibers, positively affecting film mechanical strength and stiffness, evidenced by scanning electron microscopy. Nanosized or blend chitosan film sensitivity to moisture was significantly decreased with the drop in biocomposite molecular masses, evidenced by increased water solubility and decreased water vapor permeability. Nanosized and chitosan interactions gave rise to light biobased films presenting discrete opacity and color changes, since red-green and yellow-blue colorations were affected. All chitosan blend films exhibited antimicrobial activity against both Gram-positive and Gram-negative bacteria. The performance of green unplasticized chitosan blend films displaying diverse morphologies has, thus, been proven as a potential step towards the design of nontoxic food packaging biobased films, protecting against spoilage microorganisms, while also minimizing environmental impacts.
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–4
Authors: Mangoni Arduino , Guillou Catherine , Vanden Eynde Jean , Hulme Christopher , Jampilek Josef , Li Wei , Prokai-Tatrai Katalin , Rautio Jarkko , Collina Simona , Tuccinardi Tiziano , Sousa Maria , Sabatier Jean-Marc , Galdiero Stefania , Karaman Rafik , Kokotos George , Torri Giangiacomo , Luque F. , Vasconcelos M. , Hadjipavlou-Litina Dimitra , Siciliano Carlo , Gütschow Michael , Ragno Rino , Gomes Paula , Agrofoglio Luigi , Muñoz-Torrero Diego
Published: December 2018

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials, which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules. [...]
Efficient Synthesis of PVDF/PI Side-by-Side Bicomponent Nanofiber Membrane with Enhanced Mechanical Strength and Good Thermal Stability
Authors: Cai Ming , He Hongwei , Zhang Xiao , Yan Xu , Li Jianxin , Chen Fuxing , Yuan Ding , Ning Xin
Published: December 2018

Bicomponent composite fibers, due to their unique versatility, have attracted great attention in many fields, such as filtration, energy, and bioengineering. Herein, we efficiently fabricated polyvinylidene fluoride/polyimide (PVDF/PI) side-by-side bicomponent nanofibers based on electrospinning, which resulted in the synergism between PVDF and PI, and eventually obtained the effect of 1 + 1 > 2. Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) were used to characterize the morphology and chemical structure of nanofibers, indicating that a large number of side-by-side nanofibers were successfully prepared. Further, the thermal stability, mechanical strength, and filtration properties of PVDF/PI were carefully investigated. The results revealed that the bicomponent nanofibers possessed both good mechanical strength and remarkable thermal stability. Moreover, the mechanical properties of PVDF/ PI were strengthened by more than twice after the heat treatment (7.28 MPa at 25 °C, 15.49 MPa at 230 °C). Simultaneously, after the heat treatment at 230 °C for 30 min, the filtration efficiency of PVDF/PI membrane was maintained at about 95.45 ± 1.09%, and the pressure drop was relatively low. Therefore, the prepared PVDF/PI side-by-side bicomponent nanofibers have a favorable prospect of application in the field of medium- and high-temperature filtration, which further expands the application range of electrospun fiber membranes.
Preparation and Properties of SiBCO Aerogel and Its Composites
Authors: Li Xiafei , Feng Junzong , Yin Jie , Jiang Yonggang , Feng Jian
Published: December 2018

To obtain new high-temperature resistant composites that can meet the requirements of aircraft development for thermal insulation and mechanical properties, SiBCO aerogel composites were prepared by sol-gel, supercritical drying and high-temperature pyrolysis with trimethyl borate (TMB) or phenylboronic acid (PBA) as the boron source and mullite fiber as reinforcement. The structure and composition of the SiBCO aerogel and its composites were characterized with SEM, FT-IR, ICP and nitrogen adsorption tests. The specific surface area of the SiBCO aerogel is 293.22 m2/g, and the pore size is concentrated in the range of 10–150 nm. The mechanical properties, the thermal insulation properties and the temperature resistance were also studied. Due to the introduction of boron, the temperature resistance of SiBCO aerogel composites is improved greatly, and the service temperature of composites reached 1773 K. When n (TMB)/n (TEOS) = 1/1, the temperature resistance of the composites is the best. After heating in air at 1773 K for 30 min, the shrinkage of SiBCO aerogel composites is only 2.45%, and the thermal conductivity of the composites is 0.138 W/(m·K) at 1773 K. In addition, the type and amount of catalyst also have certain effects on the mechanical properties and temperature resistance of the composites.
Solid Lipid Nanoparticles Loading Idebenone Ester with Pyroglutamic Acid: In Vitro Antioxidant Activity and In Vivo Topical Efficacy
Authors: Montenegro Lucia , Panico Anna Maria , Santagati Ludovica Maria , Siciliano Edy Angela , Intagliata Sebastiano , Modica Maria N.
Published: December 2018

Idebenone (IDE), a strong antioxidant widely investigated for the treatment of neurodegenerative diseases and skin disorders, shows low oral and topical bioavailability due to its unfavorable physico-chemical properties. In this work, to improve IDE topical effectiveness, we explored a two-steps approach: (1) we synthesized an IDE ester (IDEPCA) with pyroglutamic acid, a molecule whose hydrating effects are well known; (2) we loaded IDEPCA into solid lipid nanocarriers (SLN). We evaluated in vitro antioxidant and anti-glycation activity and in vivo hydrating effects after topical application in human volunteers from gel vehicles of IDEPCA SLN in comparison to IDE SLN. All SLN showed good technological properties (mean particle size < 25 nm, polydispersity index < 0.300, good stability). The oxygen radical absorbance capacity assay showed that IDEPCA SLN and IDE SLN had similar antioxidant activity while IDEPCA SLN were more effective in the in vitro NO scavenging assay. Both IDEPCA and IDE SLN showed the same effectiveness in inhibiting the formation of advanced glycation end products. In vivo experiments pointed out a better hydrating effect of IDEPCA SLN in comparison to IDE SLN. These results suggest that the investigated approach could be a promising strategy to obtain topical formulations with increased hydrating effects.
Domino Reaction for the Sustainable Functionalization of Few-Layer Graphene
Authors: Barbera Vincenzina , Brambilla Luigi , Milani Alberto , Palazzolo Alberto , Castiglioni Chiara , Vitale Alessandra , Bongiovanni Roberta , Galimberti Maurizio
Published: December 2018

The mechanism for the functionalization of graphene layers with pyrrole compounds was investigated. Liquid 1,2,5-trimethylpyrrole (TMP) was heated in air in the presence of a high surface area nanosized graphite (HSAG), at temperatures between 80 °C and 180 °C. After the thermal treatments solid and liquid samples, separated by centrifugation, were analysed by means of Raman, Fourier Transform Infrared (FT-IR) spectroscopy, X-Rays Photoelectron Spectroscopy (XPS) and 1H-Nuclear Magnetic Resonance (1H NMR) spectroscopy and High Resolution Transmission Electron Microscopy (HRTEM). FT-IR spectra were interpreted with the support of Density Functional Theory (DFT) quantum chemical modelling. Raman findings suggested that the bulk structure of HSAG remained substantially unaltered, without intercalation products. FT-IR and XPS spectra showed the presence of oxidized TMP derivatives on the solid adducts, in a much larger amount than in the liquid. For thermal treatments at T ≥ 150 °C, IR spectral features revealed not only the presence of oxidized products but also the reaction of intra-annular double bond of TMP with HSAG. XPS spectroscopy showed the increase of the ratio between C(sp2)N bonds involved in the aromatic system and C(sp3)N bonds, resulting from reaction of the pyrrole moiety, observed while increasing the temperature from 130 °C to 180 °C. All these findings, supported by modeling, led to hypothesize a cascade reaction involving a carbocatalyzed oxidation of the pyrrole compound followed by Diels-Alder cycloaddition. Graphene layers play a twofold role: at the early stages of the reaction, they behave as a catalyst for the oxidation of TMP and then they become the substrate for the cycloaddition reaction. Such sustainable functionalization, which does not produce by-products, allows us to use the pyrrole compounds for decorating sp2 carbon allotropes without altering their bulk structure and smooths the path for their wider application.
A Green Approach for Preparing High-Loaded Sepiolite/Polymer Biocomposites
Authors: Di Credico Barbara , Tagliaro Irene , Cobani Elkid , Conzatti Lucia , D’Arienzo Massimiliano , Giannini Luca , Mascotto Simone , Scotti Roberto , Stagnaro Paola , Tadiello Luciano
Published: December 2018

Global industry is showing a great interest in the field of sustainability owing to the increased attention for ecological safety and utilization of renewable materials. For the scientific community, the challenge lies in the identification of greener synthetic approaches for reducing the environmental impact. In this context, we propose the preparation of novel biocomposites consisting of natural rubber latex (NRL) and sepiolite (Sep) fibers through the latex compounding technique (LCT), an ecofriendly approach where the filler is directly mixed with a stable elastomer colloid. This strategy favors a homogeneous dispersion of hydrophilic Sep fibers in the rubber matrix, allowing the production of high-loaded sepiolite/natural rubber (Sep/NR) without the use of surfactants. The main physicochemical parameters which control Sep aggregation processes in the aqueous medium were comprehensively investigated and a flocculation mechanism was proposed. The uniform Sep distribution in the rubber matrix, characteristic of the proposed LCT, and the percolative filler network improved the mechanical performances of Sep/NR biocomposites in comparison to those of analogous materials prepared by conventional melt-mixing. These outcomes indicate the suitability of the adopted sustainable procedure for the production of high-loaded clay–rubber nanocomposites with remarkable mechanical features.
LINC00261 and the Adjacent Gene FOXA2 Are Epithelial Markers and Are Suppressed during Lung Cancer Tumorigenesis and Progression
Authors: Dhamija Sonam , Becker Andrea C. , Sharma Yogita , Myacheva Ksenia , Seiler Jeanette , Diederichs Sven
Published: December 2018

Lung cancer continues to be the leading cause of cancer-related deaths worldwide, with little improvement in patient survival rates in the past decade. Long non-coding RNAs (lncRNAs) are gaining importance as possible biomarkers with prognostic potential. By large-scale data mining, we identified LINC00261 as a lncRNA which was significantly downregulated in lung cancer. Low expression of LINC00261 was associated with recurrence and poor patient survival in lung adenocarcinoma. Moreover, the gene pair of LINC00261 and its neighbor FOXA2 were significantly co-regulated. LINC00261 as well as FOXA2 negatively correlated with markers for epithelial-to-mesenchymal transition (EMT) and were suppressed by the EMT inducer TGFβ. Hierarchical clustering of gene expression data from lung cancer cell lines could further verify the association of high LINC00261/FOXA2 expression to an epithelial gene signature. Furthermore, higher expression of the LINC00261/FOXA2 locus was associated with lung cancer cell lines with lower migratory capacity. All these data establish LINC00261 and FOXA2 as an epithelial-specific marker pair, downregulated during EMT and lung cancer progression, and associated with lower cell migration potential in lung cancer cells.
Dietary Patterns and Their Sociodemographic and Lifestyle Determinants in Switzerland: Results from the National Nutrition Survey menuCH
Authors: Krieger Jean-Philippe , Pestoni Giulia , Cabaset Sophie , Brombach Christine , Sych Janice , Schader Christian , Faeh David , Rohrmann Sabine
Published: December 2018

From a public health perspective, determinants of diets are crucial to identify, but they remain unclear in Switzerland. Hence, we sought to define current dietary patterns and their sociodemographic and lifestyle determinants using the national nutrition survey menuCH (2014–2015, n = 2057). First, we applied multiple factorial analysis and hierarchical clustering on the energy-standardised daily consumption of 17 food categories. Four dietary patterns were identified (“Swiss traditional”: high intakes of dairy products and chocolate, n = 744; “Western 1”: soft drinks and meat, n = 383; “Western 2”: alcohol, meat and starchy, n = 444; and “Prudent”: n = 486). Second, we used multinomial logistic regression to examine the determinants of the four dietary patterns: ten sociodemographic or lifestyle factors (sex, age, body mass index, language region, nationality, marital status, income, physical activity, smoking status, and being on a weight-loss diet) were significantly associated with the dietary patterns. Notably, belonging to the French- and Italian-speaking regions of Switzerland increased the odds of following a “Prudent” diet (Odds ratio [95% confidence interval]: 1.92 [1.45–2.53] and 1.68 [0.98–2.90], respectively) compared to the German-speaking regions. Our findings highlight the influence of sociodemographic and lifestyle parameters on diet and the particularities of the language regions of Switzerland. These results provide the basis for public health interventions targeted for population subgroups.
The Relationship of Eating Rate and Degree of Chewing to Body Weight Status among Preschool Children in Japan: A Nationwide Cross-Sectional Study
Authors: Okubo Hitomi , Murakami Kentaro , Masayasu Shizuko , Sasaki Satoshi
Published: December 2018

There is growing recognition that eating slowly is associated with a lower risk of obesity, and chewing well might be an effective way to reduce the eating rate. However, little is known about these relationships among children. We therefore investigated the associations of eating rate and chewing degree with weight status among 4451 Japanese children aged 5–6 years. Information on eating rate (slow, medium, or fast), degree of chewing (not well, medium, or well), and nutrient intake of children were collected from guardians using a diet history questionnaire. Weight status was defined using the International Obesity Task Force cut-offs based on BMI calculated from guardian-reported height and weight. The prevalence of overweight and thinness was 10.4% and 14.3%, respectively. A higher eating rate and a lower degree of chewing were associated with being overweight (both p < 0.001). Eating slowly was associated with being thin (p < 0.001), but no association was observed between chewing degree and thinness. These associations were still evident after controlling for potential confounders including parental educational attainment, weight status, and the child’s nutrient intake. In conclusion, this cross-sectional study suggested that chewing well, rather than eating slowly, might be a more effective way for healthy weight management among Japanese preschool children.
A High Adherence to Six Food Targets of the Mediterranean Diet in the Late First Trimester is Associated with a Reduction in the Risk of Materno-Foetal Outcomes: The St. Carlos Gestational Diabetes Mellitus Prevention Study
Authors: Assaf-Balut Carla , García de la Torre Nuria , Fuentes Manuel , Durán Alejandra , Bordiú Elena , Del Valle Laura , Valerio Johanna , Jiménez Inés , Herraiz Miguel Angel , Izquierdo Nuria , Torrejón María José , De Miguel María Paz , Barabash Ana , Cuesta Martín , Rubio Miguel Angel , Calle-Pascual Alfonso Luis
Published: December 2018

A prenatal diet affects materno-foetal outcomes. This is a post hoc analysis of the St. Carlos gestational diabetes mellitus (GDM) Prevention Study. It aims to evaluate the effect of a late first-trimester (>12 gestational weeks) degree of adherence to a MedDiet pattern—based on six food targets—on a composite of materno-foetal outcomes (CMFCs). The CMFCs were defined as having emergency C-section, perineal trauma, pregnancy-induced hypertension and preeclampsia, prematurity, large-for-gestational-age, and/or small-for-gestational-age. A total of 874 women were stratified into three groups according to late first-trimester compliance with six food targets: >12 servings/week of vegetables, >12 servings/week of fruits, <2 servings/week of juice, >3 servings/week of nuts, >6 days/week consumption of extra virgin olive oil (EVOO), and ≥40 mL/day of EVOO. High adherence was defined as complying with 5–6 targets; moderate adherence 2–4 targets; low adherence 0–1 targets. There was a linear association between high, moderate, and low adherence, and a lower risk of GDM, CMFCs, urinary tract infections (UTI), prematurity, and small-for-gestational-age (SGA) newborns (all p < 0.05). The odds ratios (95% CI) for GDM and CMFCs in women with a high adherence were 0.35((0.18–0.67), p = 0.002) and 0.23((0.11–0.48), p < 0.001), respectively. Late first-trimester high adherence to the predefined six food targets is associated with a reduction in the risk of GDM, CMFCs, UTI, prematurity, and SGA new-borns.
Intranasal Delivery of Genistein-Loaded Nanoparticles as a Potential Preventive System against Neurodegenerative Disorders
Authors: Rassu Giovanna , Porcu Elena Piera , Fancello Silvia , Obinu Antonella , Senes Nina , Galleri Grazia , Migheli Rossana , Gavini Elisabetta , Giunchedi Paolo
Published: December 2018

Genistein has been reported to have antioxidant and neuroprotective activity. Despite encouraging in vitro and in vivo results, several disadvantages such as poor water solubility, rapid metabolism, and low oral bioavailability limit the clinical application of genistein. The aim of this study was to design and characterize genistein-loaded chitosan nanoparticles for intranasal drug delivery, prepared by the ionic gelation technique by using sodium hexametaphosphate. Nanoparticles were characterized in vitro and their cytotoxicity was tested on PC12 cells. Genistein-loaded nanoparticles were prepared, and sodium hexametaphosphate was used as a valid alternative to well-known cross-linkers. Nanoparticle characteristics as well as their physical stability were affected by formulation composition and manufacturing. Small (mean diameters of 200–300 nm) and homogeneous nanoparticles were obtained and were able to improve genistein penetration through the nasal mucosa as compared to pure genistein. Nanoparticle dispersions showed a pH consistent with the nasal fluid and preserved PC12 cell vitality.
Soil Physics Involvement in the Germination Ecology of Buried Weed Seeds
Authors: Benvenuti Stefano , Mazzoncini Marco
Published: December 2018

Trials were performed to test the germination ecology of buried weed seeds as a function of physical soil conditions such as of burial depth, texture, and compaction. Indeed, these ecological conditions, due to the adopted agronomic practices, play a crucial role in modulating the seed bank germination dynamics. Experiments were carried out in open fields in confined soils (polypropylene pipes), and in the laboratory in Petri dishes. Sowing depth strongly inhibited the seed germination of the three weed species selected. This inhibition was found to be inversely proportional to the size of the soil particles. Compaction strongly increased the depth-mediated inhibition, especially in soils that were rich in clay particles, and was inversely proportional to the seed size. The physiological nature of the dormancy imposed by burial was investigated. In addition, ungerminated seeds, re-exhumed after deep-sowing for six months, were found to be in deep dormancy, especially after burial in compacted clay soil. This dormancy induction was more pronounced in weed species characterized by small seeds. Critical issues are discussed regarding weed seed bank ecophysiology and their management in sustainable agricultural cropping systems.
Synthesis and Evaluation of Thermoresponsive Boron-Containing Poly(N-isopropylacrylamide) Diblock Copolymers for Self-Assembling Nanomicellar Boron Carriers
Authors: Yoneoka Shuichiro , Park Ki Chul , Nakagawa Yasuhiro , Ebara Mitsuhiro , Tsukahara Takehiko
Published: December 2018

Development of new boron nanocarriers has been a crucial issue to be solved for advancing boron neutron capture therapy (BNCT) as an effective radiation treatment for cancers. The present study aimed to create a novel double-thermoresponsive boron-containing diblock copolymer based on poly(N-isopropylacrylamide) [poly(NIPAAm)], which exhibits two-step phase transitions (morphological transitions) at the temperature region below human body temperature. The boronated diblock copolymer considerably concentrates boron atoms into the water-dispersible (i.e., intravenous-administration possible) nanomicelles self-assembled by the first phase transition, and furthermore the properly controlled size and hydrophobicity of the second phase-transitioned nanoparticles are expected to make a significant contribution to the selective delivery and long-term retention of boron atoms into tumor tissues. Here we present the detailed synthesis of the strategic NIPAAm-based diblock copolymer with 3-acrylamidophenylboronic acid (PBA), i.e., poly(NIPAAm-block-NIPAAm-co-PBA), through a reversible addition-fragmentation chain transfer polymerization. Furthermore, the stepwise phase transition behavior of the obtained boronic-acid diblock copolymers was characterized in detail by temperature-variable 1H and 11B-nuclear magnetic resonance spectroscopy. The phase-transition-induced molecular structural changes, including the structural compositions and sizes of nanomicelles and nanoparticles, are also discussed here.
Effects of Tung Oil-Based Polyols on the Thermal Stability, Flame Retardancy, and Mechanical Properties of Rigid Polyurethane Foam
Authors: Zhou Wei , Bo Caiying , Jia Puyou , Zhou Yonghong , Zhang Meng
Published: December 2018

A phosphorus-containing tung oil-based polyol (PTOP) and a silicon-containing tung oil-based polyol (PTOSi) were each efficiently prepared by attaching 9,10-dihydro-9-oxa-10-phosphaphenanthrene (DOPO) and dihydroxydiphenylsilane (DPSD) directly, respectively, to the epoxidized monoglyceride of tung oil (EGTO) through a ring-opening reaction. The two new polyols were used in the formation of rigid polyurethane foam (RPUF), which displayed great thermal stability and excellent flame retardancy performance. The limiting oxygen index (LOI) value of RPUF containing 80 wt % PTOP and 80 wt % PTOSi was 24.0% and 23.4%, respectively. Fourier transfer infrared (FTIR), Nuclear Magnetic Resonance (NMR) and thermogravimetric (TG) analysis revealed that DOPO and DPSD are linked to EGTO by a covalent bond. Interestingly, PTOP and PTOSi had opposite effects on Tg and the compressive strength of RPUF, where, with the appropriate loading, the compressive strengths were 0.82 MPa and 0.25 MPa, respectively. At a higher loading of PTOP and PTOSi, the thermal conductivity of RPUF increased while the RPUF density decreased. The scanning electron microscope (SEM) micrographs showed that the size and closed areas of the RPUF cells were regular. SEM micrographs of the char after combustion showed that the char layer was compact and dense. The enhanced flame retardancy of RPUF resulted from the barrier effect of the char layer, which was covered with incombustible substance.
Highly Permeable Matrimid®/PIM-EA(H2)-TB Blend Membrane for Gas Separation
Authors: Esposito Elisa , Mazzei Irene , Monteleone Marcello , Fuoco Alessio , Carta Mariolino , McKeown Neil , Malpass-Evans Richard , Jansen Johannes
Published: December 2018

The effect on the gas transport properties of Matrimid®5218 of blending with the polymer of intrinsic microporosity PIM-EA(H2)-TB was studied by pure and mixed gas permeation measurements. Membranes of the two neat polymers and their 50/50 wt % blend were prepared by solution casting from a dilute solution in dichloromethane. The pure gas permeability and diffusion coefficients of H2, He, O2, N2, CO2 and CH4 were determined by the time lag method in a traditional fixed volume gas permeation setup. Mixed gas permeability measurements with a 35/65 vol % CO2/CH4 mixture and a 15/85 vol % CO2/N2 mixture were performed on a novel variable volume setup with on-line mass spectrometric analysis of the permeate composition, with the unique feature that it is also able to determine the mixed gas diffusion coefficients. It was found that the permeability of Matrimid increased approximately 20-fold with the addition of 50 wt % PIM-EA(H2)-TB. Mixed gas permeation measurements showed a slightly stronger pressure dependence for selectivity of separation of the CO2/CH4 mixture as compared to the CO2/N2 mixture, particularly for both the blended membrane and the pure PIM. The mixed gas selectivity was slightly higher than for pure gases, and although N2 and CH4 diffusion coefficients strongly increase in the presence of CO2, their solubility is dramatically reduced as a result of competitive sorption. A full analysis is provided of the difference between the pure and mixed gas transport parameters of PIM-EA(H2)-TB, Matrimid®5218 and their 50:50 wt % blend, including unique mixed gas diffusion coefficients.
Developing a Polypropylene Fabric, Silica Fume, and Redispersible Emulsion Powder Cementitious Composite for Dynamic Water Environment
Authors: Liu Jinquan , Li Xiaofei , Saffari Pooya , Liang Qichao , Li Ling , Chen Weizhong
Published: December 2018

In the dynamic water environment, grouting requires a material with higher strength and anti-washout performance to prevent groundwater inrush. This study aims to develop a dynamic water slurry by mixing polypropylene fiber (PP fiber), silica fume (SF) and the polymer material of redispersible emulsion powder (REP) to the Portland cement. Towards this aim, a series of tests, including strength, gel time, bleeding rate, fluidity, and anti-washout, were conducted to evaluate the effects of SF, PP fiber, and REP on the slurry properties. The test results show that: (1) SF displays significant effects on strength, gel time, fluidity, and bleeding rate of cement slurry. Differently, PP fiber mainly affects the stress–strain behavior of the slurry and can improve the ductility significantly. (2) By mixing SF and fiber simultaneously, the slurry strength can increase by about 30%, and its strain can extend by more than 70%. Meanwhile, the composite slurry possesses great anti-washout properties at a low flow velocity (v ≤ 0.4 m/s), and the grouting retention rate (GRR) can reach up to 98.7%. However, the GRR decreases to a maximum value of 31.3% when v = 0.6 m/s. (3) By mixing the REP into the fiber-SF composite slurry, the GRR can further increase, reaching more than 60% even when v = 0.6 m/s. As a result, the developed fiber-SF cementitious composite slurry, which when mixed with REP, presents a favorable performance in the dynamic water environment.
Dynamic Performance Assessment of Primary Frequency Modulation for a Power Control System Based on MATLAB
Authors: Li Shizhe , Wang Yinsong
Published: December 2018

The primary frequency modulation (PFM) performance of a power control system (PCS) is an important factor affecting the security and stability of a power grid. The traditional control method is proportional integral (PI) control. In order to improve its dynamic control performance, a control method based on the combination of internal model control (IMC) and PI is proposed. Using the method of theoretical assessment and system identification, a simple simulated model of the typical PCS is established. According to the principle of system identification and the least square estimation (LSE) algorithm, the mathematical models of a generator and a built-in model are established. According to the four dynamic performance indexes, the main and auxiliary assessment index of the PCS are defined, and the benchmark and the result of the performance assessment are given. According to three different structures, the PFM dynamic performance of the PCS is analyzed separately. According to the dynamic performance assessment index of PFM, the structure of the control system and the influence of different parameters on the performance of the PCS are analyzed under ideal conditions. The appropriate control structure and controller parameters are determined. Secondly, under the non-ideal condition, the influence of the actual valve flow coefficient on the performance of the control system is studied under two different valve control modes. The simulation results show that the internal model combined with PI has better dynamic control performance and stronger robustness than the traditional PI control, and it also has better application prospects for thermal power plants.
Pluralism and the Roots of Social Conflict: Rethinking Rawls
Authors: Friedline Mary Leah
Published: December 2018

Attempts to refine or update definitions of pluralism in political theology and philosophy often, implicitly or explicitly, entail an account of the roots of social conflict, which pluralism is meant to address. Using the influential work of John Rawls as a starting point I further investigate the idea that the root of social conflict stems from competing beliefs systems. I conclude that Rawls’s account of social conflict is insufficiently complex, intersectional, or historicist, and his theory of pluralism and his treatment of religion suffer because of this.
The Hyphen in the Theological-Political: Spinoza to Mendelssohn, Heine, and Derrida
Authors: Goetschel Willi
Published: December 2018

Spinoza’s Theological-Political Treatise introduced the unique catchphrase of the theological-political. While commanding popular currency, the full implications of the phrase is rarely considered in terms of modern Jewish thought. This paper examines how paying close attention to the hyphen helps us better understand the critical role of the hyphen in Spinoza and its significance for Mendelssohn, Heine, and Derrida’s critical agenda of rethinking the theological-political.