bluuebunny/crossref_metadata_2025 huggingface dataset:
Outcomes of Adrenal Venous Sampling in Patients with Bilateral Adrenal Masses and ACTH‐Independent Cushing’s Syndrome
Authors: Acharya Runa , Dhir Mashaal , Bandi Rupal , Yip Linwah , Challinor Sue
Published: September 2018

Background

Management of patients with bilateral adrenal masses and ACTH‐independent Cushing’s syndrome (AICS) is challenging, as bilateral adrenalectomy can lead to steroid dependence and lifelong risk of adrenal crisis. Adrenal venous sampling (AVS) has been previously reported to facilitate lateralization for guiding adrenalectomy. The aim of the current study was to investigate the utility of AVS using protocol from study by Young et al. in the management of patients with bilateral adrenal masses and AICS.

Methods and design

A retrospective review of all patients with bilateral adrenal masses and AICS who underwent AVS from 2008 to 2016 was performed. AVS for cortisol and epinephrine was performed with dexamethasone suppression. The adrenal vein to peripheral vein cortisol ratios and side‐to‐side cortisol lateralization ratios were calculated.

Results

AVS was successful in 8 of 9 patients. All 8 patients had AVS results indicating bilateral cortisol hypersecretion. Six patients underwent adrenalectomy: 3 had unilateral adrenalectomy of the larger size mass, 2 had bilateral adrenalectomy (both sides >4 cm.) and 1 had stepwise bilateral adrenalectomy. Final pathology revealed macronodular adrenal hyperplasia in all 6 patients that underwent surgery.

Conclusion

AVS was useful in excluding a unilateral adenoma as the source of AICS in this study of patients with bilateral adrenal masses and AICS. However, adrenal mass size influenced surgical decision making more than AVS results. More data are needed before AVS can be advocated as essential for management of patients with bilateral adrenal masses and AICS.
Antimicrobial stewardship for acute-care hospitals: An Asian perspective
Authors: Apisarnthanarak Anucha , Kwa Andrea Lay-Hoon , Chiu Cheng-Hsun , Kumar Suresh , Thu Le Thi Anh , Tan Ban Hock , Zong Zhiyong , Chuang Yin Ching , Karuniawati Anis , Tayzon Maria Fe , So Thomas Man-Kit , Peterson Lance R.
Published: September 2018

Inappropriate use of antibiotics is contributing to a serious antimicrobial resistance problem in Asian hospitals. Despite resource constraints in the region, all Asian hospitals should implement antimicrobial stewardship (AMS) programs to optimize antibiotic treatment, improve patient outcomes, and minimize antimicrobial resistance. This document describes a consensus statement from a panel of regional experts to help multidisciplinary AMS teams design programs that suit the needs and resources of their hospitals. In general, AMS teams must decide on appropriate interventions (eg, prospective audit and/or formulary restriction) for their hospital, focusing on the most misused antibiotics and problematic multidrug-resistant organisms. This focus is likely to include carbapenem use with the goal to reduce carbapenem-resistant gram-negative bacteria. Rather than initially trying to introduce a comprehensive, hospital-wide AMS program, it would be practical to begin by pilot testing a simple program based on 1 achievable core intervention for the hospital. AMS team members must work together to determine the most suitable AMS interventions to implement in their hospitals and how best to put them into practice. Continuous monitoring and feedback of outcomes to the AMS teams, hospital administration, and prescribers will enhance sustainability of the AMS programs.
The apparatus of the Carboniferous conodont Vogelgnathus simplicatus and the early evolution of the genus
Authors: Sanz-López Javier , Blanco-Ferrera Silvia , Miller C. Giles
Published: September 2018

The apparatus of Vogelgnathus simplicatus (Rhodes, Austin, and Druce, 1969) is reconstructed from discrete elements from a sample of limited diversity from the Limerick Province (Ireland). The apparatus is typical of the order Ozarkodinida and the P1 element was previously placed within Gnathodus. Here we assign it to Vogelgnathus by applying a multielemental concept rather than using P1 element morphology. The holotype and paratypes are re-illustrated and the species distribution revised based on published data. Vogelgnathus simplicatus ranges from the late Tournaisian to the early Viséan (Mississippian, Carboniferous), with common occurrences relating to the growth of Waulsortian bank complexes in a high-stand sea-level along the southern and western margins of the Laurussian landmass (Belgium, the British Isles, the Republic of Ireland, and USA). Vogelgnathus simplicatus appears to represent the rootstock from which deep-water and shallow-water Viséan species of Vogelgnathus evolved in the Mississippian.
Protean Masculinity, Hegemonic Masculinity: Soldiers in the Third Reich
Authors: Kühne Thomas
Published: September 2018

Hegemonic masculinity in Nazi Germany, as well as in many militarized societies around the globe, meant physical, emotional, and moral “hardness.” The ideal man, embodied by the soldier, was tough and aggressive, in control of his body, mind, and psyche. He did not hesitate to sacrifice life and limb on behalf of the Fatherland, or to subordinate his individuality under the command of a conformist group of comrades. Whereas many scholars have already stressed these features of hegemonic masculinity, this article argues that the act of soldiering provided men with a male identity that was ultimately not defined by the repudiation, but ratherintegration, of what was (and is) often coded as feminine. In the social practice of male interaction, diversity and flexibility were needed, thus allowing for the display of femininely coded behavior like affection, tenderness, empathy, caring, and tolerance toward emotional breakdowns and moments of weakness in their midst. Thanks to its inclusive nature, such “protean” masculinity enabled different types of soldier-men to establish male identities; it also allowed them to switch among different emotional and moral states without losing their manliness. Yet, this was true only if the predominance of hardness was respected. Eventually, protean masculinity integrated diverse men and diverse emotional and moral conditions into a fighting unit, and, in the case of the Third Reich, into a genocidal society.
“Muscle”Yekkes? Multiple German-Jewish Masculinities in Palestine and Israel after 1933
Authors: Farges Patrick
Published: September 2018

In the 1930s and 1940s, nearly ninety thousand German-speaking Jews found refuge in the British Mandate of Palestine. While scholars have stressed the so-calledYekkes’intellectual and cultural contribution to the making of the Jewish nation, their social and gendered lifeworlds still need to be explored. This article, which is centered on the generation of those born between 1910 and 1925, explores an ongoing interest in German-Jewish multiple masculinities. It is based on personal narratives, including some 150 oral history interviews conducted in the early 1990s with German-speaking men and women in Israel. By focusing on gender and masculinities, it sheds new light on social, generational, and racial issues in Mandatory Palestine and Israel. The article presents an investigation of the lives, experiences, and gendered identities of young emigrants from Nazi Europe who had partly been socialized in Europe, and were then forced to adjust to a different sociey and culture after migration. This involved adopting new forms of sociability, learning new body postures and gestures, as well as incorporating new habits—which, together, formed a cultural repertoire for how to behave as a “New Hebrew.”
Commentary: Masculinity and the Racial State
Authors: Dillon Christopher
Published: September 2018

In their 1991 monograph on Nazi Germany,The Racial State, Michael Burleigh and Wolfgang Wippermann asked why it was “acceptable to use anthropological categories in the case of youth or women, and apparently unacceptable to employ them in the case of men?” The expansive historiography of Nazism, they complained, offered nothing “beyond an isolated venture into the realm of male fantasies, or a few studies of homosexuals.” The answer, in fact, had a lot more to do with scholarly motivation than acceptability. Put starkly, there was no intellectualfrissonin recovering the history of “men” as a social category in Nazi Germany. Influential asThe Racial Stateproved to be in driving the research agenda for historians of National Socialism, the authors’ ensuing chapter, “Men in the Third Reich,” merely confirmed as much. It presented a dry, empirical overview of Nazi racial and economic policies, excised of those specifically directed at women and children. The termsgender,masculine, ormasculinitydo not appear once in thirty-six dense pages of text. To be sure, this reflected the wider state of knowledge in the academy. Now, almost three decades later, historians can draw on a sociology of gender relations that was still in its infancy when Burleigh and Wippermann were writing. They study “men” to decode historical configurations of power. They no longer conceive of women, children, and men as discrete actor groups, but as protagonists in systems of gender relations. A sophisticated interdisciplinary literature has rendered men legible as gendered subjects, rather than as an unmarked norm. This scholarship stresses the plurality of masculine identities. It advises that a racial state, like all known states, will be a patriarchal institution, and that the gendering of oppressed ethnic minorities plays a key role in the construction of majority femininities and masculinities. By pondering the relationship between racial and social identities in Nazi Germany, Burleigh and Wippermann nevertheless raised questions with which historians continue to grapple. Each of the contributors to this special issue ofCentral European Historyfocuses productively on the intersection of gender, ethnicity, and power in the “racial state.”
Drinking Rituals, Masculinity, and Mass Murder in Nazi Germany
Authors: Westermann Edward B.
Published: September 2018

During the Third Reich, alcohol served as both a literal and metaphorical lubricant for acts of violence and atrocity by the men of theSturmabteilung(SA), theSchutzstaffel(SS), and the police. Scholars have extensively documented its use and abuse on the part of the perpetrators. For the SA, the SS, and the police, the consumption of alcohol was part of a ritual that not only bound the perpetrators together, but also became a facilitator of acts of “performative masculinity”—a type of masculinity expressly linked to physical or sexual violence. In many respects, the relationship among alcohol, masculinity, sex, and violence permeated all aspects of the Nazi killing process in the camps, the ghettos, and the killing fields. After the outbreak of war in September 1939, such practices were increasingly radicalized, with drinking and celebratory rituals becoming key elements for these closed male communities of perpetrators, who used them to prepare for acts of mass killing and, ultimately, genocide.
Whining and Winning: Male Narratives of Love, Marriage, and Divorce in the Shadow of the Third Reich
Authors: Mailänder Elissa
Published: September 2018

This article analyzes the social realities that Austrian and German heterosexual men, all in their reproductive age, confronted in the aftermath of World War II; the kind of sexual and gendered configurations produced under Nazism and during the postwar period; and the ways in which these social and emotional realities were publically and privately dealt with after the war. It draws on reports in, and letters-to-the-editor of, the journalLiebe und Ehefrom 1949 to 1951, as well as on a sample of fourteen private letters written by an Austrian policeman in 1951 about his love relationship with a nurse. Such early postwar narratives not only point at issues and conflicts between the sexes, but also suggest the rehabilitation of traditional gender roles in West Germany and Austria. Men struggled to conform to new guidelines of heterosexual domesticity, a development that hints not only at traumatic war experiences, but also at the ideological residuals of Nazism.
Upstart Industrialization and Exports: Evidence from Japan, 1880–1910
Authors: Meissner Christopher M. , Tang John P.
Published: September 2018

Between 1880 and 1910, Japanese exports increased in volume, changed composition, and shifted from leading industrialized countries toward poorer Asian neighbors. Using a new dataset disaggregated by product and trade partner for the universe of Japanese exports, we findextensive marginsaccounted for 30 percent of export growth, with trade costs and market size associated with successful market entry. There was also considerable persistence in maintaining market presence and exit was rare. These stylized facts provide insight into both the country’s economic development, as reflected in its exported products, as well as the demand conditions of its trade partners.
Relationship Bank Behavior during Borrower Distress
Authors: Li Yan , Lu Ruichang , Srinivasan Anand
Published: September 2018

This article provides a comprehensive examination of the time-series behavior of relationship banks around and during borrower distress. Relationship and outside loans have similar interest rates during distress and even 2 years prior to distress. Relative to outside loans in distress, relationship loans in distress have lower maturity. The fraction of bank lending given by relationship banks reduces during borrower distress. Overall, borrowers in distress do not derive benefits from relationship banks. These findings are inconsistent with models that suggest banks have an implicit commitment to help their borrowers in distress due to reputation concerns.
Regional Economic Activity and Stock Returns
Authors: Smajlbegovic Esad
Published: September 2018

This paper studies the diffusion of regional macroeconomic information into stock prices. I identify all U.S. states that are economically relevant for a company through textual analysis of annual reports and find that economic activity forecasts of company-relevant regions positively predict cross-sectional stock returns. Information arising from all relevant states is more important than that relating to the headquarter state alone. These forecasts also predict firms’ performance and earnings surprises, suggesting that the return predictability stems from future cash flows that are gradually reflected in prices. Finally, regional information takes longer to be incorporated into prices among difficult-to-arbitrage stocks.
CEOs and the Product Market: When Are Powerful CEOs Beneficial?
Authors: Li Minwen , Lu Yao , Phillips Gordon M.
Published: September 2018

We examine whether industry product market conditions are important in assessing the benefits and costs of chief executive officer (CEO) power. We find that firms are more likely to have powerful CEOs in high demand product markets where firms are facing entry threats. In these markets, investors react favorably to announcements granting more power to CEOs, and CEO power is associated with higher market value, sales growth, investment, advertising, and the introduction of more new products. Our results remain significant when addressing the endogeneity of CEO power by instrumenting CEO power with past non-CEO executive and director sudden deaths.
The Effect of Financial Flexibility on Payout Policy
Authors: Kumar Anil , Vergara-Alert Carles
Published: September 2018

We use variation in real estate prices as exogenous shocks to firms’ debt capacity to study the causal effect of financial flexibility on payout policy. We show that an increase in financial flexibility results in higher dividends, share repurchases, and payout flexibility. We find that a 1-standard-deviation increase in a firms’ collateral value results in 0.26- and 0.55-percentage-point increases in nondiscretionary and discretionary payouts, respectively. This effect is stronger for firms with few investment opportunities. Moreover, highly leveraged firms are more likely to cut dividends in response to a sharp decrease in their financial flexibility.
Trauma-associated anterior cingulate connectivity during reward learning predicts affective and anxiety states in young adults
Authors: Eckstrand Kristen L. , Hanford Lindsay C. , Bertocci Michele A. , Chase Henry W. , Greenberg Tsafrir , Lockovich Jeanette , Stiffler Ricki , Aslam Haris A. , Graur Simona , Bebko Genna , Forbes Erika E. , Phillips Mary L.
Published: September 2018

Background

Trauma exposure is associated with development of depression and anxiety; yet, some individuals are resilient to these trauma-associated effects. Differentiating mechanisms underlying development of negative affect and resilience following trauma is critical for developing effective interventions. One pathway through which trauma could exert its effects on negative affect is reward-learning networks. In this study, we examined relationships among lifetime trauma, reward-learning network function, and emotional states in young adults.

Methods

One hundred eleven young adults self-reported trauma and emotional states and underwent functional magnetic resonance imaging during a monetary reward task. Trauma-associated neural activation and functional connectivity were analyzed during reward prediction error (RPE). Relationships between trauma-associated neural functioning and affective and anxiety symptoms were examined.

Results

Number of traumatic events was associated with greater ventral anterior cingulate cortex (vACC) activation, and lower vACC connectivity with the right insula, frontopolar, inferior parietal, and temporoparietal regions, during RPE. Lower trauma-associated vACC connectivity with frontoparietal regions implicated in regulatory and decision-making processes was associated with heightened affective and anxiety symptoms; lower vACC connectivity with insular regions implicated in interoception was associated with lower affective and anxiety symptoms.

Conclusions

In a young adult sample, two pathways linked the impact of trauma on reward-learning networks with higherv.lower negative affective and anxiety symptoms. The disconnection between vACC and regions implicated in decision-making and self-referential processes may reflect aberrant regulatory but appropriate self-focused mechanisms, respectively, conferring risk forv.resilience against negative affective and anxiety symptoms.
Aberrant myelination of the cingulum and Schneiderian delusions in schizophrenia: a 7T magnetization transfer study
Authors: Palaniyappan Lena , Al-Radaideh Ali , Mougin Olivier , Das Tushar , Gowland Penny , Liddle Peter F.
Published: September 2018

Background

The structural integrity of the anterior cingulum has been repeatedly observed to be abnormal in patients with schizophrenia. More recently, aberrant myelination of frontal fasciculi, especially, cingulum has been proposed to underlie delayed corollary discharges that can affect sense of agency and contribute to delusions of control (Schneiderian delusions). Using the magnetization transfer phenomenon at an ultra-high field 7T MRI, we investigated the putative myelin content of cingulum bundle in patients with schizophrenia.

Methods

Seventeen clinically stable patients with schizophrenia and 20 controls were recruited for this 7T MRI study. We used a region-of-interest method and extracted magnetization transfer ratio (MTR) from left and right dorsal cingulum bundles and estimated patients v. controls differences. We also related the cingulum MTR values to the severity of Schneiderian delusions.

Results

Patients had a significant reduction in the MTR, indicating reduced myelin content, in the cingulum bundle (right cingulum Hedges’ g = 0.91; left cingulum g = 0.03). The reduced MTR of left cingulum was associated with higher severity of Schneiderian delusions (τ = −0.45, p = 0.026) but no such relationship was seen for the right cingulum MTR (τ = −0.136, p = 0.50) among patients. The association between the left cingulum MTR and Schneiderian delusions was not explained by the presence of other delusions, hallucinations, disorganization or negative symptoms.

Conclusions

Dysmyelination of the cingulum bundle is seen in a subgroup of patients with schizophrenia and may be involved in the mechanism of Schneiderian delusions.
Reconciliation through Estrangement
Authors: Thaler Mathias
Published: September 2018

While it is often assumed that reconciliation culminates in the comprehensive resolution of conflict between deeply alienated parties, the article argues that reconciliation can only be achieved through complex mechanisms of estrangement that reveal alternative vistas or collective renewal. Art performs an important role in this process. The article theorizes estrangement as both an artistic and a political technique that can have world-disclosing, rather than alienating, effects on its audience: what Svetlana Boym calls estrangement for, rather than from, the world. I tease out the implications of this insight by examining the South African theater pieceUbu and the Truth Commission, which employs a number of estrangements devices in order to problematize the ambiguities and uncertainties of the post-Apartheid transition period. By subverting audience identification, yet triggering emotional contagion, the play imaginatively opens up the possibility of a common world in which agonistic relations are productively negotiated, rather than fully suppressed.
Genre and linguistic expectation shift: Evidence from pop song lyrics
Authors: Squires Lauren
Published: September 2018

Popular song lyrics constitute an exception to dominant, standard language ideologies of English: nonstandard grammatical forms are common, relatively unstigmatized, and even enregistered in the genre. This project uses song lyrics to test whether genre cues can shift linguistic expectations, influencing how speakers process morphosyntactic variants. In three self-paced reading experiments, participants read sentences from pop songs. Test sentences contained either ‘standard’ NPSG+doesn'tor ‘nonstandard’ NPSG+don't. In Experiment 1, some participants were told that the sentences came from lyrics, while others received no context information. Experiment 2 eliminated other nonstandardisms in the stimuli, and Experiment 3 tested for the effect of stronger context information. Genre information caused participants to orient to the sentences differently, which partially—but not straightforwardly—mitigated surprisal at nonstandarddon't. I discuss future directions for understanding the effects of context on sociolinguistic processing, which I argue can inform concepts like genre and enregisterment, and the processes underlying language attitudes. (Morphosyntactic variation, genre, invariantdon't, language ideology, pop songs, experimental sociolinguistics, sentence processing)*
When the State Sovereign Immunity Rule Meets Sovereign Wealth Funds in the Post Financial Crisis Era: Is There Still a Black Hole in International Law?
Authors: SHANG SHU , SHEN WEI
Published: September 2018

This article examines the state sovereign immunity rule in the context of a rising number of sovereign wealth funds and their ever-increasing value of cross-border commercial activities in the aftermath of the latest global financial crisis. The concept of sovereignty and the rule of sovereignty remain in a state of flux while new actors such as sovereign wealth funds are participating in global commercial activities in a nontransparent and politically motivated manner. Accordingly, states may pursue strategic foreign policy objectives through these newer investment arms in an unconventional way, thereby being deeply involved in the political-economic arena and distorting the existing concepts of international law. This article posits that there is an international law black hole in which sovereign wealth funds have come to engage in commercial activities as well as exercise the public functions traditionally associated with states (actsjure imperii). The doctrine of restrictive immunity has come into question and the bulk of local court decisions have offered little clear guidance. Against this backdrop three interconnected perspectives are then discussed with reference to emerging economies like China: the immunity rule, the principle of sovereignty, and the balance of power in globalization.
Challenging the Paris Peace Treaties, State Sovereignty, and Western-Dominated International Law –The Multifaceted Genesis of the Jus Cogens Doctrine
Authors: LANGE FELIX
Published: September 2018

The genesis of thejus cogensdoctrine in international law has long been associated with a turn to a more value-laden international law after the Second World War promoted by British rapporteurs in the International Law Commission. This article builds on this narrative but adds two seemingly contradictory story lines. In the 1920s and 1930s German-speaking international legal scholars like Alfred Verdross developed the concept as a tool to renounce the disliked Paris Peace Treaties in the context of increasingly aggressive German revision policies. Furthermore, after 1945 Soviet thinkers of the Khrushchev era usedjus cogensto criticize Western economic and military integration, while newly independent states regarded the concept as a promising vehicle for distancing themselves from the traditional Western international legal notions in the era of decolonization. Hence, instead of embracing a progress narrative, a dark side account, or a contributionist reading of the history of international law, this article highlights the multifaceted origins of thejus cogensdoctrine.
The Prosecutor’s Request Concerning the Rohingya Deportation to Bangladesh: Certain Procedural Questions
Authors: VAGIAS MICHAIL
Published: September 2018

On 9 April 2018, the Prosecutor of the International Criminal Court filed a request seeking the composition of a Pre-Trial Chamber, in order to decide whether the Court has territorial jurisdiction over the Rohingya deportation from Myanmar to Bangladesh as a crime against humanity. This filing is a first for the Court on at least two fronts; it is the first time the Prosecutor has asked the Court to interpret Article 12(2)(a) and apply qualified territoriality; it is also the first time the Prosecutor has asked for a ruling on jurisdiction under Article 19(3).

This study explores certain procedural questions emerging from this request, such as the Court’s authority to decide while its jurisdiction is ‘dormant’; the function of Article 19(3) within the Rome Statute’s overall system concerning jurisdictional determinations; issuing a decision on jurisdiction, while avoiding prejudice to subsequent proceedings and without rendering meaningless the right to challenge jurisdiction under Article 19(2) of the Statute. The article accepts that the request is a step in the right direction, as it signals the Prosecutor’s determination to investigate the Rohingya crisis. However, the manner and timing of its presentation give rise to plausible claims of incompatibility with the Court’s procedural framework. Arguably, the Court may well instruct the Prosecutor to assume the risk of wasting precious resources and proceed with further investigations, pending the final determination of the jurisdictional question at a later stage.
-DISPLAYS AND RAPOPORT–ZINK SPACES
Authors: Bültel O. , Pappas G.
Published: September 2018

Let $(G,\unicode[STIX]{x1D707})$ be a pair of a reductive group $G$ over the $p$-adic integers and a minuscule cocharacter $\unicode[STIX]{x1D707}$ of $G$ defined over an unramified extension. We introduce and study ‘$(G,\unicode[STIX]{x1D707})$-displays’ which generalize Zink’s Witt vector displays. We use these to define certain Rapoport–Zink formal schemes purely group theoretically, i.e. without $p$-divisible groups.
Endovascular management of penetrating and non-penetrating aortic injury
Authors: Chou Elizabeth L. , Twerdahl Eric H. , Eagleton Matthew J.
Published: September 2018

Abstract. Aortic trauma is a devastating injury often associated with significant polytrauma. Penetrating injury of the aorta is highly lethal and therefore rarely encountered in the hospital setting. The management of blunt trauma of the aorta has changed significantly over the past decade, principally due to improved imaging technology and the development of endovascular therapy. The most common site of injury is the proximal descending thoracic aorta. The degree of aortic wall injury guides the indication for therapy, while a combination of the degree of injury and the extent of co-morbid injuries drives the timing of repair. Lower grade injuries frequently do not require any surgical intervention. Thoracic aortic endograft repair can be performed in a safe, expeditious fashion. Short-term and mid-term outcomes appear excellent, with patient survival based mainly on concomitant traumatic injuries. Long-term outcomes are less well known. Future endeavors will be guided toward gaining a better understanding of the indications for repair and the long-term outcomes for endograft devices designed for this purpose.
Development and Validation of the Multicontextual Interpersonal	Relations Scale (MIRS)
Authors: Simone Melissa , Geiser Christian , Lockhart Ginger
Published: September 2018

Abstract. Interpersonal relationships provide insight into a wide range of adult psychological health behaviors and well-being. Modern advancements in relational contexts (e.g., social media and phone use) have caused debate about the implications of technology use on overall interpersonal relationships and psychological health. Thus, the Multicontextual Interpersonal Relations Scale (MIRS) was developed to measure three unique processes of interpersonal relations and four unique contexts in which these activities take place. In total, N = 962 adult participants (aged 18–78 years) were recruited from the United States through Amazon Mechanical Turk, an online recruitment tool. Confirmatory factor analyses (CFAs) were conducted to examine the hypothesized factor structure, and bivariate correlations were computed to assess concurrent validity. CFA results supported a model with three process and three context (specific) factors, where face-to-face relations served as the reference context factor. Bivariate correlations revealed that the interpersonal relations factors correlated with the related constructs in the hypothesized ways. Overall, strong standardized factor loadings, item-level reliability, concurrent validity, and internal consistency support the structure and use of the MIRS. Findings suggest that participation in interpersonal relations is a multicontextual construct, requiring measurement of all unique processes and relational contexts.
Reconstruction and Future Prediction of the Distribution of Wetlands in China
Authors: Xue Zhenshan , Zou Yuanchun , Zhang Zhongsheng , Lyu Xianguo , Jiang Ming , Wu Haitao , Liu Xiaohui , Tong Shouzheng
Published: September 2018

Due to lack of historical and accurate data, less well known is how the wetlands of China were changed and affected by human disturbance and climate change during past millennia and also, whether climate warming could impact the surviving wetlands in China. Using niche‐based distribution models and downscaled climate data of the past and future, we projected the potential distribution of wetlands in China. Our results show that more than half of the wetlands in China have been destroyed over the past few millennia. Also, future warming will have a negative effect on remaining wetlands. Freshwater swamp and seasonal salt marsh are predicted to dramatically reduce under future scenarios. Wetlands in high mountain regions and inland arid regions are under threat of degeneration and water salinization. This research could provide valuable information for the future conservation and management of wetlands in China.
Patterns of polymorphism and selection in the subgenomes of the allopolyploid Arabidopsis kamchatica
Authors: Paape Timothy , Briskine Roman V. , Halstead-Nussloch Gwyneth , Lischer Heidi E. L. , Shimizu-Inatsugi Rie , Hatakeyama Masaomi , Tanaka Kenta , Nishiyama Tomoaki , Sabirov Renat , Sese Jun , Shimizu Kentaro K.
Published: September 2018

Genome duplication is widespread in wild and crop plants. However, little is known about genome-wide selection in polyploids due to the complexity of duplicated genomes. In polyploids, the patterns of purifying selection and adaptive substitutions may be affected by masking owing to duplicated genes or homeologs as well as effective population size. Here, we resequence 25 accessions of the allotetraploidArabidopsis kamchatica, which is derived from the diploid speciesA. halleriandA. lyrata. We observe a reduction in purifying selection compared with the parental species. Interestingly, proportions of adaptive non-synonymous substitutions are significantly positive in contrast to most plant species. A recurrent pattern observed in both frequency and divergence–diversity neutrality tests is that the genome-wide distributions of both subgenomes are similar, but the correlation between homeologous pairs is low. This may increase the opportunity of different evolutionary trajectories such as in theHMA4gene involved in heavy metal hyperaccumulation.
Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity
Authors: Heindl Andreas , Khan Adnan Mujahid , Rodrigues Daniel Nava , Eason Katherine , Sadanandam Anguraj , Orbegoso Cecilia , Punta Marco , Sottoriva Andrea , Lise Stefano , Banerjee Susana , Yuan Yinyin
Published: September 2018

How tumor microenvironmental forces shape plasticity of cancer cell morphology is poorly understood. Here, we conduct automated histology image and spatial statistical analyses in 514 high grade serous ovarian samples to define cancer morphological diversification within the spatial context of the microenvironment. Tumor spatial zones, where cancer cell nuclei diversify in shape, are mapped in each tumor. Integration of this spatially explicit analysis with omics and clinical data reveals a relationship between morphological diversification and the dysregulation of DNA repair, loss of nuclear integrity, and increased disease mortality. Within the Immunoreactive subtype, spatial analysis further reveals significantly lower lymphocytic infiltration within diversified zones compared with other tumor zones, suggesting that even immune-hot tumors contain cells capable of immune escape. Our findings support a model whereby a subpopulation of morphologically plastic cancer cells with dysregulated DNA repair promotes ovarian cancer progression through positive selection by immune evasion.
Quantifying climate sensitivity and climate-driven change in North American amphibian communities
Authors: Miller David A. W. , Grant Evan H. Campbell , Muths Erin , Amburgey Staci M. , Adams Michael J. , Joseph Maxwell B. , Waddle J. Hardin , Johnson Pieter T. J. , Ryan Maureen E. , Schmidt Benedikt R. , Calhoun Daniel L. , Davis Courtney L. , Fisher Robert N. , Green David M. , Hossack Blake R. , Rittenhouse Tracy A. G. , Walls Susan C. , Bailey Larissa L. , Cruickshank Sam S. , Fellers Gary M. , Gorman Thomas A. , Haas Carola A. , Hughson Ward , Pilliod David S. , Price Steven J. , Ray Andrew M. , Sadinski Walt , Saenz Daniel , Barichivich William J. , Brand Adrianne , Brehme Cheryl S. , Dagit Rosi , Delaney Katy S. , Glorioso Brad M. , Kats Lee B. , Kleeman Patrick M. , Pearl Christopher A. , Rochester Carlton J. , Riley Seth P. D. , Roth Mark , Sigafus Brent H.
Published: September 2018

Changing climate will impact species’ ranges only when environmental variability directly impacts the demography of local populations. However, measurement of demographic responses to climate change has largely been limited to single species and locations. Here we show that amphibian communities are responsive to climatic variability, using >500,000 time-series observations for 81 species across 86 North American study areas. The effect of climate on local colonization and persistence probabilities varies among eco-regions and depends on local climate, species life-histories, and taxonomic classification. We found that local species richness is most sensitive to changes in water availability during breeding and changes in winter conditions. Based on the relationships we measure, recent changes in climate cannot explain why local species richness of North American amphibians has rapidly declined. However, changing climate does explain why some populations are declining faster than others. Our results provide important insights into how amphibians respond to climate and a general framework for measuring climate impacts on species richness.
Estimating sources and sinks of malaria parasites in Madagascar
Authors: Ihantamalala Felana Angella , Herbreteau Vincent , Rakotoarimanana Feno M. J. , Rakotondramanga Jean Marius , Cauchemez Simon , Rahoilijaona Bienvenue , Pennober Gwenaëlle , Buckee Caroline O. , Rogier Christophe , Metcalf C. J. E. , Wesolowski Amy
Published: September 2018

In areas where malaria epidemiology is spatially and temporally heterogeneous, human-mediated parasite importation can result in non-locally acquired clinical cases and outbreaks in low-transmission areas. Using mobility estimates derived from the mobile phone data and spatial malaria prevalence data, we identify travel routes relevant to malaria transmission in Madagascar. We find that the primary hubs of parasite importation are in a spatially connected area of the central highlands. Surprisingly, sources of these imported infections are not spatially clustered. We then related these source locations directly to clinical cases in the low-transmission area of the capital. We find that in the capital, a major sink, the primary sources of infection are along the more populated coastal areas, although these sources are seasonally variable. Our results have implications for targeting interventions at source locations to achieve local or national malaria control goals.
Persistent repair intermediates induce senescence
Authors: Feringa F. M. , Raaijmakers J. A. , Hadders M. A. , Vaarting C. , Macurek L. , Heitink L. , Krenning L. , Medema R. H.
Published: September 2018

Double-stranded DNA breaks activate a DNA damage checkpoint in G2 phase to trigger a cell cycle arrest, which can be reversed to allow for recovery. However, damaged G2 cells can also permanently exit the cell cycle, going into senescence or apoptosis, raising the question how an individual cell decides whether to recover or withdraw from the cell cycle. Here we find that the decision to withdraw from the cell cycle in G2 is critically dependent on the progression of DNA repair. We show that delayed processing of double strand breaks through HR-mediated repair results in high levels of resected DNA and enhanced ATR-dependent signalling, allowing p21 to rise to levels at which it drives cell cycle exit. These data imply that cells have the capacity to discriminate breaks that can be repaired from breaks that are difficult to repair at a time when repair is still ongoing.
RARα supports the development of Langerhans cells and langerin-expressing conventional dendritic cells
Authors: Hashimoto-Hill Seika , Friesen Leon , Park Sungtae , Im Suji , Kaplan Mark H. , Kim Chang H.
Published: September 2018

Langerhans cells (LC) are the prototype langerin-expressing dendritic cells (DC) that reside specifically in the epidermis, but langerin-expressing conventional DCs also reside in the dermis and other tissues, yet the factors that regulate their development are unclear. Because retinoic acid receptor alpha (RARα) is highly expressed by LCs, we investigate the functions of RARα and retinoic acid (RA) in regulating the langerin-expressing DCs. Here we show that the development of LCs from embryonic and bone marrow-derived progenitors and langerin+ conventional DCs is profoundly regulated by the RARα-RA axis. During LC differentiation, RARα is required for the expression of a LC-promoting transcription factor Runx3, but suppresses that of LC-inhibiting C/EBPβ. RARα promotes the development of LCs and langerin+conventional DCs only in hypo-RA conditions, a function effectively suppressed at systemic RA levels. Our findings identify positive and negative regulatory mechanisms to tightly regulate the development of the specialized DC populations.
Simulation of slip transients and earthquakes in finite thickness shear zones with a plastic formulation
Authors: Tong Xinyue , Lavier Luc L.
Published: September 2018

We perform numerical experiments of damped quasi-dynamic fault slip that include a rate-and-state behavior at steady state to simulate earthquakes and a plastic rheology to model permanent strain. The model shear zone has a finite width which represents a natural fault zone. Here we reproduce fast and slow events that follow theoretical and observational scaling relationships for earthquakes and slow slip events (SSEs). We show that the transition between fast and slow slip occurs when the friction drop in the shear zone is equal to a critical value, Δμc. With lower friction drops, SSEs use nearly all of mechanical work to accumulate inelastic strain, while with higher friction drops fast slips use some of the mechanical work to slip frictionally. Our new formulation replaces the state evolution of rate and state by the stress evolution concurrent with accumulation of permanent damage in and around a fault zone.
Author Correction: Molecular architecture of the multifunctional collagen lysyl hydroxylase and glycosyltransferase LH3
Authors: Scietti Luigi , Chiapparino Antonella , De Giorgi Francesca , Fumagalli Marco , Khoriauli Lela , Nergadze Solomon , Basu Shibom , Olieric Vincent , Cucca Lucia , Banushi Blerida , Profumo Antonella , Giulotto Elena , Gissen Paul , Forneris Federico
Published: September 2018

The previously published version of this Article contained an error in Figure 3. In panel a, the residues His667 and Asp669 were incorrectly labelled as His627 and Asp629. The error has been corrected in both the PDF and HTML versions of the Article.
Publisher Correction: Ancient DNA from Chalcolithic Israel reveals the role of population mixture in cultural transformation
Authors: Harney Éadaoin , May Hila , Shalem Dina , Rohland Nadin , Mallick Swapan , Lazaridis Iosif , Sarig Rachel , Stewardson Kristin , Nordenfelt Susanne , Patterson Nick , Hershkovitz Israel , Reich David
Published: September 2018

In the original version of this Article, references in the format ‘First author et al.’ were inappropriately deleted. These errors have been corrected in the PDF and HTML versions of the Article.
Cluster-based network proximities for arbitrary nodal subsets
Authors: Berenhaut Kenneth S. , Barr Peter S. , Kogel Alyssa M. , Melvin Ryan L.
Published: September 2018

The concept of a cluster or community in a network context has been of considerable interest in a variety of settings in recent years. In this paper, employing random walks and geodesic distance, we introduce a unified measure of cluster-based proximity between nodes, relative to a given subset of interest. The inherent simplicity and informativeness of the approach could make it of value to researchers in a variety of scientific fields. Applicability is demonstrated via application to clustering for a number of existent data sets (including multipartite networks). We view community detection (i.e. when the full set of network nodes is considered) as simply the limiting instance of clustering (for arbitrary subsets). This perspective should add to the dialogue on what constitutes a cluster or community within a network. In regards to health-relevant attributes in social networks, identification of clusters of individuals with similar attributes can support targeting of collective interventions. The method performs well in comparisons with other approaches, based on comparative measures such as NMI and ARI.
Experimental Adaptation of the Yellow Fever Virus to the Mosquito Aedes albopictus and Potential risk of urban epidemics in Brazil, South America
Authors: Amraoui Fadila , Pain Adrien , Piorkowski Géraldine , Vazeille Marie , Couto-Lima Dinair , de Lamballerie Xavier , Lourenço-de-Oliveira Ricardo , Failloux Anna-Bella
Published: September 2018

Despite the availability of an efficient vaccine, Yellow fever (YF), a viral disease transmitted by mosquitoes, is still a threat. In Brazil, the yellow fever virus (YFV) has been restricted to a jungle cycle for more than 70 years. However, YFV has recently invaded populated cities in the Southeast such as Rio de Janeiro where the opportunistic mosquito Aedes albopictus is well established. Using in vivo passages of YFV in Ae. albopictus, we have selected viral strains presenting substitutions in NS1 gene. We did 10 passages of YFV-74018 on two distinct Ae. albopictus populations: (i) Manaus collected from a YFV-endemic area in Amazonia and (ii) PNMNI from a YFV-free area in the state of Rio de Janeiro. Full viral genomes were deep sequenced at each passage. We obtained two YFV strains presenting a non-synonymous substitution in the NS1 gene. Interestingly, they intervened at two different positions in NS1 gene according to the mosquito population: I2772T in Ae. albopictus Manaus and S3303N in Ae. albopictus PNMNI. Both substitutions reached fixation at the passage 10. Our data suggest that YFV has the potential for adaption to Ae. albopictus thereby posing a threat to most cities in South America where this mosquito is present.
Author Correction: A new artificial diet for western corn rootworm larvae is compatible with and detects resistance to all current Bt toxins
Authors: Ludwick Dalton C. , Meihls Lisa N. , Huynh Man P. , Pereira Adriano E. , French B. Wade , Coudron Thomas A. , Hibbard Bruce E.
Published: September 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Author Correction: Comparison of Image-Guided Intensity-Modulated Radiotherapy and Low-dose Rate Brachytherapy with or without External Beam Radiotherapy in Patients with Localized Prostate Cancer
Authors: Tsubokura Takuji , Yamazaki Hideya , Masui Koji , Sasaki Naomi , Shimizu Daisuke , Suzuki Gen , Nakamura Satoaki , Yamada Kei , Okihara Koji , Shiraishi Takumi , Yoshida Ken , Nishikawa Tatsuyuki , Okabe Haruumi
Published: September 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
The effects of fruit bagging on residue behavior and dietary risk for four pesticides in apple
Authors: Xu Guofeng , Nie Jiyun , Wu Yonglong , Yan Zhen , Ye Mengliang
Published: September 2018

In this study, the effects of fruit bagging on residue behavior and dietary risk for four pesticides (abamectin, imidacloprid, carbendazim and difenoconazole) in apple were investigated. The dissipation behavior of four pesticides were assessed after spraying on three occasions with the first spray at 2 months before harvest and the subsequent sprays at 10-day intervals at recommended doses of 5.4, 45, 135 and 975 g. a.i.ha−1, respectively. The dissipation experiment results demonstrated that apple fruit bagging reduced the initial deposits of four pesticides from 72.2% to 95.3%, prolonged the half-lives from 50.4% to 81.1%. The ultimate residues of abamectin, imidacloprid, carbendazim, and difenoconazole in bagged apple were far below the residues of unbagged apple. The dietary risks of four pesticides were assessed according to the ultimate residues and acceptable daily intakes (ADIs). The hazard quotient (HQ) were 0.013% to 43.415% for different pesticides. Fruit bagging reduced the HQ of four pesticides from 29.7% to 94.8%. Fruit bagging reduced the dietary risk of four pesticides in apple.