bluuebunny/crossref_metadata_2025 huggingface dataset:
Steel Structure Analysis of Workshop Facility in PT Pamapersada Nusantara
Authors: Abdul Halim Mirza , Rutama Dedy , Nawang Sari Ribut
Published: September 2022

Structural planning in building construction aims to measure a building ability in bearing occurred loads.

The structural elements must be designed and calculated based on the appropriate combination of standard loads. Workshop facility project at PT. Pamapersada Nusantara uses a steel structure with steel profiles for columns and beams. The function of the steel profile as a cross section of the structure is very important, for that it is necessary to analyze and design the right steel profile for the structural elements of steel columns and beams at the Workshop Facility Project of PT. Pamapersada Nusantara. The method used in this research is based on a case study on the object of research in the project. This building structure planning was analyzed using a computer-based structural calculation program, namely the SAP2000 v.14, referring to SNI 1729-2020 concerning Procedures for Planning Steel Structures for Buildings and SNI 1726:2019 Procedures for Planning Earthquake Resistance for Building Structures and Non-Building and SNI 1727:2020 Minimum Load for Design of Buildings and Other Structures and Indonesian Loading Regulations for Buildings (PPIUG 2019).

The

result of structure analysis using SAP2000 V.22, there were no failed frames in workshop facility structure making. For the Rafter deflection of 29.35 mm

£

31 mm (permitted deflection) and the column slenderness of 7 m (L)

³

(Lr) 5.74 m.
Survey and Review of Parallel Glossary of Indian Languages
Authors: Kumari Pratiksha , Ragit Chandrakant
Published: September 2022

The research paper highlights the survey review of the parallel vocabulary of Indian languages, which are useful for today's education world. The purpose of this research paper is to broaden the natural language resource by storing words of different languages ??and strengthen the three-lingual formula in the education world, preserve extinct languages ??and facilitate machine translation, etc.
Generic Framework Related to Database Forensics and Security Countermeasures
Authors: Muhammad Umar Munir  , Ghulam Abbas Khan  , Arslan Ammin
Published: September 2022

Governments and private organizations are rapidly moving on cloud and storing their private and business information on cloud databases. And currently cloud system is not much secure and different types of attacks are happening on databases. Databases store an expansive scope of private and open data, making them a practical objective for abuse by foes who are hoping to bargain the secrecy of information just as harm the respectability of the information or make it inaccessible to its client. It builds the establishment for the advancement and foundation of key standards in investigation of database forensics and case for forensic management. This research study strives to highlight the different vulnerabilities which are exploited by hackers and afterwards if there is intrusions how one can assess the amount of damage that has been done to the system by forensic analysis. This study also focuses on different solutions which can be used to secure the system so that the integrity of data is made possible. To further explore the forensic auditing process, the research shows the plan of assessing and developing a procedure to start with forensic analysis process. This is made sure following standard operating procedures which are used in forensic analysis and afterwards an investigation is conducted which results in determining the flaws in security and solutions to make them more protected. To sum up, this research study explores and follows a framework that can be used for analysis in a standard procedure which can be used to prove a case through legal channels. This further enables the authorities to proceed and set up a criminal case against the intruders using forensic audit.
Integration of Healthcare Services of Specialized Healthcare & Medical Education Department, Government of Punjab in Cloud-based System
Authors: Qaisar Abbas  , Muhammad Imran  , Muhammad Sajid
Published: September 2022

To know about the emergent technology in the world is cloud computing, which may utilize in the health sector to improve the mechanism for the delivery of healthcare services of Specialized Healthcare & Medical Education Department, Govt. of the Punjab, Lahore, human resources management system, budget and expenditure, pharmaceutical services, waste management, and patient treatment plan, in a cloud-based integrated system with the motive to change the storage mode of data from manually into digitally computing mod with accessing it efficiently through the cloud. Today, the major issue is to integrate the real-time patient data into cloud-based system information through the architectural design of data canal and formal models/ methods. Data privacy & data integrity are the major concerns from the security point of view. Data may protect from loss and theft to mitigate the number of attacks whichever hits from the end-user/ client, network, and cloud service providers.
Automated Diagnosing of Eye Disease in Real Time
Authors: Muhammad Rehan Faheem  , Arslan Iftikhar  , Nisar Hussain
Published: September 2022

The automated diagnosing of hypertensive retinopathy and also other diseases are rapidly increasing today. The objective of this product anticipated in the paper is to help ophthalmologists in conclusion and malady avoidance, making a difference to decide cardiovascular danger or different sicknesses where the vessels can be modified, and in addition to screening the pathology movement what's more, reaction to various medicines. With the help of Real Time devices, Eye disease is diagnosed at the early stages. Real time devices used the IOT and Cloud. By using IOT devices are able to collect and exchange data directly with other devices through the cloud computing. In this paper we, present the solution to solve the problems of patients which occurs the eye disease at real time, which is discussed in solution section.
Perancangan Sistem Informasi Persediaan Bahan Baku Produksi Berbasis Desktop
Authors: Gamaliel Fritz , Safitri Novira
Published: September 2022

Pengelolaan material sangat penting khususnya pada bagian produksi. Sehubungan dengan hal tersebut, staff material melakukan pencatatan data barang masuk dan barang keluar dalam pengelolaan bahan baku produksi. Selain itu, permintaan material yang berjalan di perusahaan masih dibuat secara manual di mana permintaan material dituliskan pada kertas yang rentan hilang atau rusak. Metode penelitian yang digunakan pada penelitian ini adalah observasi, wawancara, dokumentasi dan studi literatur dari berbagai sumber mengenai kaitannya dengan persediaan bahan baku produksi. Metode perancangan sistem informasi yang digunakan pada penelitian ini menggunakan Use Case Diagram. Metode pengembangan sistem informasi yang digunakan pada penelitian ini menggunakan metode waterfall, bahasa pemograman visual basic dengan editor  Visual Studio 2012, dan database MySQL. Hasil dari penelitian ini adalah terbentuknya suatu sistem informasi persediaan bahan baku produksi yang memudahkan department produksi khususnya bagian material dalam mengolah data material secara lebih efisien. Dengan adanya sistem informasi persediaan bahan baku produksi ini diharapkan dapat meminimalkan kesalahan dalam pengolahan data.
Kata Kunci: Produksi, Material, Desktop, Visual Studio, MySQL
Perancangan Metode Decision Tree Terhadap Sistem Perpustakaan STMIK Kuwera
Authors: Partogi Yosua , Pasaribu Alfredo
Published: September 2022

Sistem perpustakaan menjadi fasilitas penting yang mendukung sebuah institusi pendidikan khususnya universitas dalam memberikan pelayanan literatur bagi mahasiswa yang ingin menyelesaikan tugas akhir perkuliahan atau skripsi. Jumlah literatur yang saat ini ada di dalam sistem perpustakaan STMIK Kuwera membuka peluang untuk dilakukan penambahan fitur. Sistem perpustakaan yang akan dibuat penulis adalah dalam bentuk web dimana user menginput kata kunci dan sistem akan melakukan klasifikasi menggunakan metode decision tree. Penambahan fitur klasifikasi judul literatur berdasarkan kategori yang saat ini belum ada diharapkan mempermudah mahasiswa menentukan literatur yang akan dipakai. Oleh karena itu, sistem yang akan dibuat penulis adalah sistem perpustakaan yang akan membantu para calon mahasiswa yang akan menyusun skripsi untuk menghemat waktu dalam mencari kategori literatur dan daftar literatur yang sebelumnya sudah pernah digunakan hanya dengan memasukkan kata kunci judul tugas akhir.
Kata kunci : Sistem perpustakaan, kategori, decision tree
Perancangan Sistem Informasi E-Rapor Berbasis Web Pada SD Wahana Harapan Kedaung
Authors: Daniel Sirait Yohan , Pasaribu Alfredo
Published: September 2022

Penggunaan teknologi dalam dunia pendidikan sangat dibutuhkan baik untuk pengajar maupun pelajar. Internet menjadi suatu kebutuhan yang mendasar di masyarakat. Setiap sekolahpun dituntut untuk menerapkan teknologi komputer demi meningkatkan mutu sekolah. Terlebih lagi sedang diterapkannya sistem pembelajaran online di hampir seluruh sekolah khususnya di Indonesia. Saat ini, pengelolaan nilai pada SD Wahana Harapan Kedaung masih manual dengan buku penilaian yang akhrinya direkap secara manual pula pada setiap semester untuk hasil nilai akhir (rapor) siswa yang cenderung akan membutuhkan waktu yang cukup lama dalam prosesnya. Untuk rapor yang berupa cetakan dalam bentuk buku yang harus segera dikembalikan ke pihak sekolah setelah di tanda tangani oleh wali siswa, sehingga siswa/wali siswa hanya dapat melihat nilai dalam waktu singkat. Berdasarkan permasalahan ini, dihasilkan hipotesis bahwa dibutuhkan sistem pengelolaan nilai (E-Rapor) berbasis web yang memungkinkan pengelolaan nilai lebih cepat dan efisien serta dapat diakses oleh siswa/wali siswa. Dalam membangun sistem tersebut akan menggunakan metode pengembangan Waterfall, UML, basis data MySQL dan bahasa pemrograman PHP.
Kata kunci : Waterfall, E-Rapor, Basis Data, WEB
Kyphoplasty: why, when and how?
Authors: Longo Umile Giuseppe , Papalia Rocco , De Salvatore Sergio , Piccioni Valentina , Denaro Vincenzo
Published: September 2022

Introduction: Percutaneous kyphoplasty (PKP) aims to restore vertebral shape and kyphotic spine angulation, reduce pain, and allow the patient early mobilization. Compared with percutaneous vertebroplasty (PV), PKP has been reported to reduce cement leakage, increase short-term pain relief, and improve kyphotic angle restoration. In addition, PKP has been shown to be a safe and effective method for treating non-responsive pain in osteoporotic vertebral compression fractures, and to allow shorter hospitalizations. This paper aims to review the current state of PKP, looking at the procedure itself, its use and complications, and how it compares with PV. Surgical procedure: Precise placement of the inflatable balloons is required, and multiple processes must be completed before injecting the cement. A working cannula is inserted through the posterior wall of the vertebral body using a trans or parapedicular approach. Then, the balloons are inserted and inflated. Finally, the balloons are gradually removed, and polymethylmethacrylate is delivered through a blunt cannula. PKP has the same surgical indications and complications as PV. The main contraindications to PKP are unmanageable bleeding disorders, asymptomatic vertebral body fracture, allergy to bone cement, tumor mass with involvement of the spinal canal, unstable fractures or complete vertebral collapse, and neurological symptoms. Conclusion: PKP and PV are both effective treatments for individuals with painful, acute compression fractures that have failed to respond to conventional treatment.
Direct Effect of the “Proportionality Requirement of [Criminal] Sanctions”: Considerations on the European Court of Justice Overruling in the Case “NE II” (C-205/20)
Authors: Tsolka Olga
Published: September 2022

On the 8th of March 2022, the Grand Chamber of ECJ, in the case NE II, accepted the direct effect of the “proportionality requirement” of criminal nature’s sanctions provided in Art.20 of Directive 2014/67/EU, even connecting it with the prohibition of disproportionate criminal offences enshrined in Art.49 (3) of CFREU. By this crucial ruling, the Court explicitly overruled its previous case law and further determined what the obligation of the national courts is, to ensure the “full effectiveness” of the above requirement in the internal legal order. The jurisprudential change and its fundamental consequences mark a new qualitative step in the course of the “symbiotic relationship” between the EU and national (criminal) law, due to the “horizontal repercussions” of the judgment, i.e., not only in the EU legal acts similar to the above Directive, but also in those that establish minimum rules for the definition of criminal offences and penalties according to Art. 83 TFEU. In this study, an attempt is made to highlight the main issues of this overruling regarding, among others, the normative meaning of the “requirement of proportionality”, the specific implications of its direct effect on the national judge and the complex assessments which he is called upon to make – beyond the normal limits of his functional jurisdiction.
Providing a Population Based Registry Model of Drug Poisoning in Iran
Authors: Sabahi Azam , Asadi Farkhondeh , Rabiei Reza , Paydar Somayeh
Published: September 2022

Background: The prevalence of drug poisoning is on the rise in Iran due to the increased public access to drugs. A national drug poisoning registry system is a suitable tool for better management, control, and prevention of drug poisoning. Objectives: This study aimed to propose a national drug poisoning registry model for Iran. Methods: This was an applied research conducted in two major phases. In the first phase, all sources pertaining to drug poisoning registries were reviewed, and a national drug poisoning registry model was proposed. In the second phase, this model was validated and finalized using a researcher-made questionnaire and through a two-stage Delphi technique. Results: The focus of national drug poisoning activities and registry management reached the 100% consensus of experts at the Drug and Poison Information Center of the Food and Drug Organization (Ministry of Health and Medical Education). Goals, data sources, registry system structure, data set, standards, data exchange, registry features, and processes of the proposed model also achieved unanimous expert consensus. Conclusions: Given the importance of a national drug poisoning registry in gathering, storing, analyzing, and reporting the data of patients, it is essential to provide a framework for evaluating and controlling drug poisoning and for generating valuable data for decision-making. The model proposed herein can offer the information infrastructure for designing and implementing such a system.
Applications of Dexmedetomidine in Palliative and Hospice Care
Authors: Lemus Rafael , Jacobowski Natalie L. , Humphrey Lisa , Tobias Joseph D.
Published: September 2022

Although the use of dexmedetomidine is currently approved by the US Food and Drug Administration in the adult population for monitored anesthesia care and sedation during mechanical ventilation, clinical experience suggests the potential application of dexmedetomidine in the palliative care arena. The medication can provide sedation with lower risk of delirium, control or minimize the adverse effects of other medications, and augment analgesia from opioids. We conducted a computerized bibliographic search of the literature regarding dexmedetomidine use for the treatment of pain and provision of sedation during palliative and hospice care in adult and pediatric patients. The objective was to provide a general descriptive account of the physiologic effects of dexmedetomidine and review its potential applications in the field of palliative and hospice care in adult and pediatric patients. The sedative and analgesic effects of dexmedetomidine have been well studied in animal and human models. Published experience from both single case reports and small case series has demonstrated the potential therapeutic applications of dexmedetomidine in palliative and hospice care. In addition to intravenous administration, case reports have demonstrated its successful use by both the intranasal and subcutaneous routes. Although these experiences have suggested its safety and efficacy, larger series and additional clinical experience with prospective comparison to other agents are needed to further define its efficacy and role in palliative and hospice care.
Management of Idiopathic Viral Pericarditis in the Pediatric Population
Authors: Schwier Nicholas C. , Stephens Katy , Johnson Peter N.
Published: September 2022

Idiopathic (viral) pericarditis (IP) is one of the most common etiologies of acute and recurrent pericarditis in children. IP is associated with significant morbidity, and recurrence rates of IP are high and require treatment to decrease risk of recurrence and pericarditis-related chest pain. Despite significant morbidity, sparse guidance exists to comprehensively address management of IP in children. The purpose of this review is to provide an overview of the pharmacotherapy of IP in children, including clinical pearls for managing pediatric patients. Clinicians should consider using the combination of colchicine and nonsteroidal anti-inflammatory drugs (NSAIDs) as first-line therapy, in order to reduce the risk of recurrence and foster symptom improvement in IP. Colchicine dosing may vary depending on patient age, weight, concomitant pharmacotherapies, and disease states. Choice of NSAID should be based on cost, tolerability, and adverse drug events (ADEs). Children should receive higher NSAID attack dosing for >1 week to ensure a reduction in high sensitivity C-reactive protein concentrations and symptom relief. Corticosteroids should be considered last-line for treatment of IP in children, because they increase the risk of recurrence. Immunotherapies may be considered for children with multiple recurrences related to IP despite the use of NSAIDs, colchicine, and/or corticosteroids. Similar to adults, diligent monitoring should be implemented, to prevent drug-drug interactions, drug-disease interactions, and/or ADEs in children.
Evaluation of a Pharmacist-Driven Pediatric Dose Rounding Protocol
Authors: Brown Shannon V. , Patterson Richard , Davidson Tamara , Rozette Nicole A.
Published: September 2022

OBJECTIVE

Medication errors are 3 times more likely to occur in pediatric populations due to calculation and rounding errors. The objective of this study was to determine the effect of a pharmacist-driven pediatric dose rounding protocol on the dose rounding of medications, measurable volumes of inpatient and discharge prescriptions, and potential cost savings.

METHODS

This single center, quasi-experimental study evaluated patients younger than or equal to 18 years of age prescribed intravenous or enteral liquid medications during an inpatient, observation, or emergency department encounter. The primary outcome of rate of measurable dose volumes was evaluated pre- and post-implementation of the protocol. Secondary outcomes, including the number of discharge prescriptions affected by pharmacist dose rounding, an evaluation of protocol effect, and prescriptions dose rounded to limit the number of packages per dose, were evaluated using a cross-sectional analysis of the post-group.

RESULTS

Four hundred seventy-seven patients and 1060 medications were evaluated in a 1-month period. The rate of measurable volumes increased from 72% to 93% in the post-group (p = 0.0001). In the post-group, 197 patients had 313 medications dose rounded by pharmacists per protocol. Of the 55 discharge medications in the post-group, 21 prescriptions (38%) matched inpatient orders that had been dose rounded by pharmacists. Twenty-four medications were rounded down to a whole package size resulting in an estimated cost savings of $117 (approximately $1400 per year).

CONCLUSIONS

Implementation of a pharmacist-driven dose rounding protocol significantly increased the rate of measurable volumes administered to pediatric patients at our institution.
Evaluation and Implementation of KIDs List Recommendations in a University Health System
Authors: Anderson Victoria H. , Anderson Jordan , Durham Sarah , Collard Erin
Published: September 2022

OBJECTIVE

The study aims to identify the rate of inappropriate prescribing per the Key Potentially Inappropriate Drugs in Pediatrics (KIDs) List versus total prescribing in patients at University of Missouri Health Care hospitals.

METHODS

This retrospective study evaluated orders for patients treated at University of Missouri Health Care inpatient units or emergency departments with a KIDs List medication between September 1, 2019, and September 1, 2020, or a reported adverse event to one of these medications between September 1, 2015, and September 1, 2020. Patients were excluded if the patient safety report was related to a medication error rather than an adverse event. Safety measures assessed included age and weight filtering, dose-range checking, clinical decision support, and override availability.

RESULTS

There were 39 inappropriate orders and 4 possible adverse events identified. A total of 8 of 33 medications (24%) had age and weight filtering in place for at least 1 order sentence, 1 of 38 (2.6%) had dose-range checking, no medications had an active clinical decision support alert, and 33 of 38 (87%) had availability on automated dispensing cabinet override.

CONCLUSIONS

Use of KIDs List medications is appropriately low, but low levels of safety measure implementation leave pediatric patients vulnerable.
Simulation of calcium-ion Coulomb crystal structure and motion trajectory in linear ion traps
Authors: Hongshuo Zhang  , Yongzhuang Zhou  , Yong Shen  , Hongxin Zou  ,   National Defense University, Faculty of Science, Institute of Quantum Information
Published: September 2022

Coulomb crystal yields a wide range of applications including quantum computing and simulation, phase transitions, quantum logic spectroscopy, nonlinear dynamics and chaos, chemical reaction process, etc. The structure of the Coulomb crystal and the trajectory of each trapped ion are typically determined by the parameters of the trap and the ion species. However, dark ions are often inevitable in experiments, which introduces uncertainty to the desired crystal structures and ion trajectories. Few research has been conducted to investigate the configuration change of the crystal in the presence of dark ions and the influence of a dark ion on its surrounding ion trajectories in a multi-ion system. In this paper, we utilize the molecular dynamics simulation software LAMMPS and the (py)Lion package (modified to adapt the semi-classical theory of laser cooling) for the simulation of the 3D ion trajectories of Coulomb crystals. The formation process of 40Ca+ Coulomb crystals in a linear trap is simulated. With the micromotion and secular motion trajectories of each ion, we calculate the temperature of Coulomb crystal and the average velocity of specific ions. It’s observed that the crystal structure exhibits obvious layering phenomenon when the trapped ions yield a large difference in their charge-to-mass ratio (CMR), however, layering is not obvious with a small difference in the CMR. In addition, we simulate and compare the Coulomb crystal structure formed by pure 40Ca+ ions and that formed by 40Ca+ ions mixed with a small number of dark ions including isotopic ions (44Ca+) and impurity ions (CaH+). Three different cases are investigated, namely the 1D ion string, 2D plane structure and 3D helical structure. Results show that ions in the neighborhood of a dark ion exhibit around micron-order position changes compared to their positions before the dark ion is formed. Such a change can be measured in experiment through microscopic imaging, providing a way to identify dark ions in Column crystals with a large number of ions.
Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor
Authors: Gogolou Antigoni , Souilhol Celine , Granata Ilaria , Wymeersch Filip J , Manipur Ichcha , Wind Matthew , Frith Thomas JR , Guarini Maria , Bertero Alessandro , Bock Christoph , Halbritter Florian , Takasato Minoru , Guarracino Mario R , Tsakiridis Anestis
Published: September 2022

The neural crest (NC) is an important multipotent embryonic cell population and its impaired specification leads to various developmental defects, often in an anteroposterior (A-P) axial level-specific manner. The mechanisms underlying the correct A-P regionalisation of human NC cells remain elusive. Recent studies have indicated that trunk NC cells, the presumed precursors of childhood tumour neuroblastoma, are derived from neuromesodermal-potent progenitors of the postcranial body. Here we employ human embryonic stem cell differentiation to define how neuromesodermal progenitor (NMP)-derived NC cells acquire a posterior axial identity. We show that TBXT, a pro-mesodermal transcription factor, mediates early posterior NC/spinal cord regionalisation together with WNT signalling effectors. This occurs by TBXT-driven chromatin remodelling via its binding in key enhancers within HOX gene clusters and other posterior regulator-associated loci. This initial posteriorisation event is succeeded by a second phase of trunk HOX gene control that marks the differentiation of NMPs toward their TBXT-negative NC/spinal cord derivatives and relies predominantly on FGF signalling. Our work reveals a previously unknown role of TBXT in influencing posterior NC fate and points to the existence of temporally discrete, cell type-dependent modes of posterior axial identity control.
Comparative mitogenomic analyses and gene rearrangements reject the alleged polyphyly of a bivalve genus
Authors: Cunha Regina L. , Nicastro Katy R. , Zardi Gerardo I. , Madeira Celine , McQuaid Christopher D. , Cox Cymon J. , Castilho Rita
Published: September 2022

Background

The order and orientation of genes encoded by animal mitogenomes are typically conserved, although there is increasing evidence of multiple rearrangements among mollusks. The mitogenome from a Brazilian brown mussel (hereafter named B1) classified as Perna perna Linnaeus, 1758 and assembled from Illumina short-length reads revealed an unusual gene order very different from other congeneric species. Previous mitogenomic analyses based on the Brazilian specimen and other Mytilidae suggested the polyphyly of the genus Perna.

Methods

To confirm the proposed gene rearrangements, we sequenced a second Brazilian P. perna specimen using the “primer-walking” method and performed the assembly using as reference Perna canaliculus. This time-consuming sequencing method is highly effective when assessing gene order because it relies on sequentially-determined, overlapping fragments. We also sequenced the mitogenomes of eastern and southwestern South African P. perna lineages to analyze the existence of putative intraspecific gene order changes as the two lineages show overlapping distributions but do not exhibit a sister relationship.

Results

The three P. perna mitogenomes sequenced in this study exhibit the same gene order as the reference. CREx, a software that heuristically determines rearrangement scenarios, identified numerous gene order changes between B1 and our P. perna mitogenomes, rejecting the previously proposed gene order for the species. Our results validate the monophyly of the genus Perna and indicate a misidentification of B1.
Comparative Glycemic Control in Adult Patients with Type 2 Diabetes on Herbal and Conventional Glucose-Lowering Agents in Nairobi County, Kenya
Authors: Karara Monicah W. , Okalebo Faith Apolot , Ndirangu Peter K. , Opanga Sylvia A.
Published: September 2022

Background: Some diabetic patients seek care exclusively from traditional herbal practitioners. It is not known if the care provided by herbalists is effective in maintaining optimal glycemic control.

Aim: To compare glycemic control in adult patients with type 2 diabetes on treatment with conventional medicines against those on herbal glucose-lowering therapies.

Study Design: Descriptive cross-sectional study.

Place and Duration of Study: Patients on conventional treatment were recruited from the Endocrinology and Diabetes Outpatient Centre at Kenyatta National Hospital. The comparative group was enrolled from the New Life Herbal Clinic. The study was carried out between March 2019 and December 2021.

Methodology: We recruited 80 patients on treatment with conventional antidiabetic therapies at Kenyatta National Hospital (KNH) and 37 patients on herbal therapies at New Life Herbal Clinic (NLHC). A structured questionnaire was used to collect sociodemographic and clinical data.  Consecutive sampling was used to recruit the study participants. Glycated hemoglobin (HbA1C) levels were measured at the time of the patient visit.

Patients with HbA1c levels <7% were considered to have achieved adequate glycemic control.  Descriptive and inferential data analysis was performed on all the variables and compared across the two study arms. Regression analysis was performed to identify variables associated with glycemic control for each treatment group. Data were entered into and analyzed using SPSS software version 26 (SPSS Inc, Chicago, USA).  P-values <0.05 were considered to be statistically significant.

Results: Patients on conventional antidiabetic medications had significantly lower mean HbA1c levels (7.40+1.92) % compared to (8.34+1.97) % in the herbal treatment arm (P=0.016).  Significant differences in mean HbA1c % were reported in patients on a combination of 5-6 herbs (7.06 +1.54) % compared to those on 3-4 herbs (8.63+1.91) % (P= 0.045). Significant predictors of adequate glycemic control (HbA1c< 7%) were having a past  HbA1c check ( (aOR= 3.098 (95% C.I=1.258-7.631) P=.014), adherence to medications ( (aOR= 6.055  (95% C.I=1.623-22.593) P= .007), treatment with  Launaea cornuta ( (aOR= 7.143 (95% C.I=1.462-34.893) P= 0.015) and being  married (aOR=2.870 (95% C.I=1.054-7.818) P=0.039).

Conclusion: Patients on treatment with conventional agents reported better glycemic control compared to those on herbal therapies. Regular monitoring of HbA1c, adherence to medications, having a spouse and treatment with Launaea cornuta may enhance blood glucose control in patients with type 2 diabetes.
Translation Strategies in Indonesian Subtitle and Dubbing of The Greatest Showman
Authors: Jane Yovita , Rini Julia Eka
Published: September 2022

Several studies have compared translation strategies to analyze subtitles and dubbing in movies, but few have compared the differences between the two mediums. This study compared the translation strategies used in movie subtitles and dubbing. Baker's (2018) translation strategies are used to analyze the Disney+ subtitle and dubbing of The Greatest Showman. Baker (2018) identifies 12 translation strategies used in the subtitle and dubbing: general word, more neutral/less expressive word, cultural substitution, loan word and explanation, paraphrase using related words, paraphrase using unrelated words, omission, idiom of similar meaning and form, idiom of similar meaning but dissimilar form, paraphrase, omission of a play on idiom, omission of entire idiom. One strategy, borrowing the source language idiom, employed by the dubbing is not found in the subtitle and one strategy, illustration, is not used in both. The fact that using the same strategy does not produce the same translation result shows that there are infinite interpretations. Keywords: translation strategies, subtitle, dubbing
Simultatem Chronicles: The Fear of Imagination and Discrimination and Their Impacts on Preteenagers
Authors: Nurtanto Levana Vivian , Limanta Liem Satya
Published: September 2022

This short story series is a coming-of-age and dystopian series that focuses on the impacts of the fear of imagination and discrimination on preteens and how they cope with it. This fear is shown through a virus named imaginatio virus, a special virus that attacks the main characters to induce imagination. The government made imagination-prevention and discrimination rules to get rid of the virus completely. We explore how the fear of imagination and discrimination affect the four main characters in each story. We apply the theory of social influence, discrimination, and coping mechanisms to show how Dylan, Elias, Bryna, and Corina deal with the effects of discrimination. In our creative work, we show that the four main characters succeed in being confident by focusing on the strength in themselves, finding help in trusted people, and not dwelling in the problem. Keywords: imagination, short stories, discrimination, dystopian, coming-of-age
Types Of Conversation In The Movie The Intern
Authors: Marianto Rian
Published: September 2022

I am interested in this study “Types of Conversation in the Movie The Intern” because I want to learn about how people interact and communicate in the workplace. The way people use language as their media and from that I am interested to know about how an employee communicate with other employees and how they communicate with their boss. Of course, on the contrary, I also interested to learn how a boss communicate to their employees. In this study I took theory of social situation of language use as my theory and I focus on interactional and transactional conversation analysis. The social situation of language use based on the participants, locale or setting, topics and function. I choose those theories because it is related to my study and it help me to understand about the social situation of language use. Hopefully, this study will help me and other people to understand about how to interact and communicate with fellow partners and the boss in the workplace.Keywords: Analysis, conversation, interactional conversation, transactional conversation, and situation
Withering Lily: Human Struggle to Face the Negative Effects of Social Media
Authors: Margaretha Chrissya
Published: September 2022

This creative thesis focuses on understanding the relation between using social media and social anxiety. The goal of this work is to understand what causes the disorder to appear after exposures to social media and the effect it has on someone. To reach that goal, this creative thesis uses the Presentation of Self Theory and Social Anxiety theory to understand how social media could cause social anxiety and how it affects their life externally . It shows that the problem comes from the desire to become “perfect” in society and after that it would lead to the heightened fear of judgement that is the trigger of social anxiety. Further, social anxiety would prevent someone from living a good social life. Therefore, by understanding people’s desire to be “perfect” and the effects of social anxiety, we can see that being overly afraid of being judged on social media could ruin someone’s life.Keywords: Social Media, Social Anxiety, Presentation of Self, Screenplay, Cyberpunk
Treatment‐planning approaches to intensity modulated proton therapy and the impact on dose‐weighted linear energy transfer
Authors: Faught Austin M. , Wilson Lydia J. , Gargone Melissa , Pirlepesov Fakhriddin , Moskvin Vadim P. , Hua Chia‐Ho
Published: September 2022

Purpose

We quantified the effect of various forward‐based treatment‐planning strategies in proton therapy on dose‐weighted linear energy transfer (LETd). By maintaining the dosimetric quality at a clinically acceptable level, we aimed to evaluate the differences in LETd among various treatment‐planning approaches and their practicality in minimizing biologic uncertainties associated with LETd.

Method

Eight treatment‐planning strategies that are achievable in commercial treatment‐planning systems were applied on a cylindrical water phantom and four pediatric brain tumor cases. Each planning strategy was compared to either an opposed lateral plan (phantom study) or original clinical plan (patient study). Deviations in mean and maximum LETd from clinically acceptable dose distributions were compared.

Results

In the phantom study, using a range shifter and altering the robust scenarios during optimization had the largest effect on the mean clinical target volume LETd, which was reduced from 4.5 to 3.9 keV/μm in both cases. Variations in the intersection angle between beams had the largest effect on LETd in a ring defined 3 to 5 mm outside the target. When beam intersection angles were reduced from opposed laterals (180°) to 120°, 90°, and 60°, corresponding maximum LETd increased from 7.9 to 8.9, 10.9, and 12.2 keV/μm, respectively. A clear trend in mean and maximum LETd variations in the clinical cases could not be established, though spatial distribution of LETd suggested a strong dependence on patient anatomy and treatment geometry.

Conclusion

Changes in LETd from treatment‐plan setup follow intuitive trends in a controlled phantom experiment. Anatomical and other patient‐specific considerations, however, can preclude generalizable strategies in clinical cases. For pediatric cranial radiation therapy, we recommend using opposed lateral treatment fields to treat midline targets.
Low‐Temperature Melt Processing Monolithic Integration of Organic Manganese (II) Bromide Wafers with Pixelated Substrate for High Sensitivity X‐Ray Imaging
Authors: Li Hengxin , Lei Yutian , Peng Guoqiang , Wang Qian , Li ZhenHua , Wang Haoxu , Wang Gang , Jin Zhiwen
Published: September 2022

Environmentally‐friendly metal halides have become emerging candidates for X‐ray imaging applications. However, it remains challenging to obtain noise and ion migration suppressed crystal structures. More seriously, integration with mature circuits in an easy‐to‐implement manner is a huge obstacle to commercialization. Here, a 0D structure‐based benzyltrimethylammonium manganese bromide (BTA2MnBr4, BTA: C10H16N) is reported. Further studies point out that such structure exhibits obvious quantum confinement effects, providing large bandgap (3.20 eV) and exciton activation energy (≈115 meV) with decreasing thermal noise, and large activation energy for ionic transport (≈0.37 eV) with limited ion migration. Then, the BTA2MnBr4 wafer is fabricated via solvent‐free, scalable, and low‐temperature (175 °C) melt processing technology. The obtained wafer shows highly crystalline and good densification that can effectively collect the generated charges, which avoids the compound losses and further limits the ion migration. As a result, the related X‐ray detector demonstrates high sensitivity of 5.56 × 103 µC Gyair−1 cm−2, a low detection limit of 8.7 nGyair s−1, fast response (≈10 ms), high‐spatial resolution (≈4.1 lp mm−1), good stability, and imaging capability. Moreover, the integration of the wafer with pixelated electrode substrate is also successfully achieved, applied, and validated with strong mechanical connection and reliable contact.
Solvated Sodium Storage via a Coadsorptive Mechanism in Microcrystalline Graphite Fiber
Authors: Liu Xiaoxu , Wang Tian , Zhang Tengsheng , Sun Zhihao , Ji Tianyi , Tian Jing , Wang Hui , Hao Xiaodong , Liu Hui , Chao Dongliang
Published: September 2022

Graphite has been widely accepted for its reversible solvated sodium cointercalation mechanism into the graphite layers in ether‐based electrolytes. However, the cointercalation suffers from insufficient Coulombic efficiency with high redox potentials, which significantly limits its energy output. Herein, instead of the conventional solvated Na+ cointercalation into the graphite, a new coadsorptive mechanism is proposed through the microcrystalline graphite fiber (MCGF), which can reversibly store the solvated Na+ at the ribboned grain boundaries and in the mesopores of the MCGF. The mechanism is manifested by various advanced spectroscopy techniques, including in situ synchrotron small‐angle X‐ray scattering to track the long‐periodic structure evolution and ex situ synchrotron X‐ray absorption fine structure to verify the interaction of solvated Na and graphite layers. The origin of the boosted rate‐capability and reversibility is further revealed by density functional theory simulations and aberration‐corrected transmission electron microscopy. As a proof‐of‐concept, the MCGF electrode exhibits high initial coulombic efficiency (92.5%), fast‐charging (within 4 min), and enhanced cycling stability (≈98% retention after 800 cycles). The results provide a new understanding of the sodium storage mechanism in graphite‐based materials, which may inspire further exploration of carbon electrodes for Na‐ion batteries.
Bifunctional Platinum‐Incorporated Polyoxoniobate Derived Catalyst for N‐formylation of Piperidine Using CO2
Authors: Chudatemiya Vorakit , Kikkawa Soichi , Hirayama Jun , Takahata Ryo , Teranishi Toshiharu , Tamura Masazumi , Yamazoe Seiji
Published: September 2022

Alkaline salt of platinum‐incorporated heteropolyoxoniobate [Pt(Nb6O19)2]12− (Pt(Nb6)2) was fabricated and applied for N‐formylation of various amines including piperidine under CO2 and H2 atmosphere. Pt(Nb6)2 achieved the selective formation of 1‐formylpiperidine, whereas the absence of Pt species, H2, and CO2 resulted in a trace amount of the product. The structural characterization revealed that the sandwich‐type structure of Pt(Nb6)2 was transformed into Pt nanoparticles incorporated with polyoxoniobates ([Nb6O19]8−) on the NbOx bulk matrix (NbPOM‐PtNPs/NbOx) under reaction conditions. The N‐formylation of amines in the presence of CO2 and H2 proceeded by the bifunctional NbPOM‐PtNPs/NbOx where the basic sites of [Nb6O19]8− and the redox property of Pt promoted the generation of formamides.
Stimuli Responsive Silylene: Electromerism Induced Reversible Switching Between Mono‐ and Bis‐Silylene
Authors: Yadav Ravi , Sun Xiaofei , Köppe Ralf , Gamer Michael T. , Weigend Florian , Roesky Peter W.
Published: September 2022

Electromerism is a very well‐known phenomenon in transition metal chemistry. In main group chemistry, this concept has only started getting attention recently. We report stimuli responsive low‐valent silicon compounds exhibiting electromerism. A mixed‐valent silaiminyl‐silylene1, [LSi−Si(NDipp)L] (L=PhC(NtBu)2), was synthesized in a single step from amidinate‐chlorosilylene. Compound1has two interconnected Si atoms in formally +I and +III oxidation states. Upon treatment with Lewis acidic CuIX (X=mesityl, Cl, Br, I), electron redistribution occurs resulting in the formation of [{LSi(NDipp)Si(L)}−CuX], in which both silicon atoms are in the +II formal oxidation state. Removal of the copper center from [{LSi(NDipp)Si(L)}−CuX] by using a Lewis basic carbene led to reformation of the precursor [LSi−Si(NDipp)L]. Thus, the process is fully reversible. This showcases the first example of Lewis acid/base‐induced reversible electromerism in silicon chemistry.
Erklärbare domänenspezifische Künstliche Intelligenz im Massiv‐ und Brückenbau
Authors: Kraus Michael A.
Published: September 2022

Der Einsatz von Künstlicher Intelligenz (KI) wird derzeit flächendeckend in Forschung und Praxis aller Branchen diskutiert und evaluiert. Dieser Beitrag vermittelt zunächst das notwendige Hintergrundwissen zur allgemeinen KI und erarbeitet dann die Notwendigkeit der Entwicklung von domänenspezifischer KI sowie erklärbarer KI (XAI) für die Berechnungs‐ und Bemessungspraxis im Bauwesen. Dabei wird die Rolle der Domäne „Bauingenieurwesen“ an der Schnittstelle zur KI im Hinblick auf Daten sowie Modellierungs‐ und Bemessungsphilosophie diskutiert. Die drei Beispiele (i) Berechnung von Kirchhoff‐Platten mit physikinformierten Neuronalen Netzen, (ii) Kalibrierung von Prior‐Modellen für den parametrischen Brückenentwurf aus Datenbanken und (iii) der KI‐unterstützte konzeptionelle Entwurf von Brücken veranschaulichen die Anwendung von domänenspezifischem Maschinellem und Tiefem Lernen sowie XAI mit besonderem Blick auf den Massiv‐ und Brückenbau. Insbesondere die physikinformierte KI (piKI) stellt eine Alternative zu etablierten numerischen Verfahren unter besonderer Berücksichtigung vorhandener Simulations‐ und Versuchsdaten dar und wird über den Einsatz von XAI erklärbar und nachvollziehbar. Dies ebnet den Weg zur Nutzung der Modelle der piKI im Bauwesen als Digitale Zwillinge eines Tragwerks über deren Lebenszyklen.
A nonparametric method for classification trees using grouped covariates
Authors: Lin Feng‐Chang , Shih Yu‐Shan , Yu Yuan‐Bin
Published: September 2022

A group of variables are commonly seen in diagnostic medicine when multiple prognostic factors are aggregated into a composite score to represent the risk profile. A model selection method considers these covariates as all‐in or all‐out types. Model selection procedures for grouped covariates and their applications have thrived in recent years, in part because of the development of genetic research in which gene–gene or gene–environment interactions and regulatory network pathways are considered groups of individual variables. However, little has been discussed on how to utilize grouped covariates to grow a classification tree. In this paper, we propose a nonparametric method to address the selection of split variables for grouped covariates and their following selection of split points. Comprehensive simulations were implemented to show the superiority of our procedures compared to a commonly used recursive partition algorithm. The practical use of our method is demonstrated through a real data analysis that uses a group of prognostic factors to classify the successful mobilization of peripheral blood stem cells.
A Simple Colorimetric Assay of Bleomycin‐Mediated DNA Cleavage Utilizing Double‐Stranded DNA‐Modified Gold Nanoparticles
Authors: Akiyama Yoshitsugu , Kimura Kazunori , Komatsu Syuuhei , Takarada Tohru , Maeda Mizuo , Kikuchi Akihiko
Published: September 2022

A colorimetric assay of DNA cleavage by bleomycin (BLM) derivatives was developed utilizing high colloidal stability on double‐stranded (ds) DNA‐modified gold nanoparticles (dsDNA‐AuNPs) possessing a cleavage site. The assay was performed using dsDNA‐AuNPs treated with inactive BLM or activated BLM (Fe(II)⋅BLM). A 10‐min exposure in dsDNA‐AuNPs with inactive BLM treatment resulted in a rapid color change from red to purple because of salt‐induced non‐crosslinking aggregation of dsDNA‐AuNPs. In contrast, the addition of active Fe(II)⋅BLM retained the red color, probably because of the formation of protruding structures at the outermost phase of dsDNA‐AuNPs caused by BLM‐mediated DNA cleavage. Furthermore, the results of our model experiments indicate that oxidative base release and DNA‐cleavage pathways could be visually distinguished with color change. The present methodology was also applicable to model screening assays using several drugs with different mechanisms related to antitumor activity. These results strongly suggest that this assay with a rapid color change could lead to simple and efficient screening of potent antitumor agents.
Effects of Fluid Properties on Rod Seal Stick‐Slip Mechanical and Sound Vibrations
Authors: Ogunsola Oluwaseyi , Shahid Jazil Bin , Michael Paul
Published: September 2022

The effect of fluid properties on hydraulic cylinder rod seal stick‐slip friction was studied. Breakaway and stick‐slip forces were measured for three ISO VG 32 fluids with slipper, U‐cup, and Vee‐pack seals. Breakaway forces increased exponentially with dwell time. Stick‐slip friction produced audible low‐frequency noise. Differences in the stick‐slip behavior of the fluids were observed. Fast Fourier transform analysis of sound, force, and mechanical vibrations was conducted. Stick‐slip friction increased the amplitude of low‐frequency vibrations in all three domains. Micro stick‐slip movement was elucidated via motion amplification technology. These findings provide a basis for the development of fluids that improve the control and safety of hydraulic equipment.