bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi-decadal surface ozone trends at globally distributed remote locations
Authors: Cooper Owen R. , Schultz Martin G. , Schröder Sabine , Chang Kai-Lan , Gaudel Audrey , Benítez Gerardo Carbajal , Cuevas Emilio , Fröhlich Marina , Galbally Ian E. , Molloy Suzie , Kubistin Dagmar , Lu Xiao , McClure-Begley Audra , Nédélec Philippe , O’Brien Jason , Oltmans Samuel J. , Petropavlovskikh Irina , Ries Ludwig , Senik Irina , Sjöberg Karin , Solberg Sverre , Spain Gerard T. , Spangl Wolfgang , Steinbacher Martin , Tarasick David , Thouret Valerie , Xu Xiaobin
Published: June 2020

Extracting globally representative trend information from lower tropospheric ozone observations is extremely difficult due to the highly variable distribution and interannual variability of ozone, and the ongoing shift of ozone precursor emissions from high latitudes to low latitudes. Here we report surface ozone trends at 27 globally distributed remote locations (20 in the Northern Hemisphere, 7 in the Southern Hemisphere), focusing on continuous time series that extend from the present back to at least 1995. While these sites are only representative of less than 25% of the global surface area, this analysis provides a range of regional long-term ozone trends for the evaluation of global chemistry-climate models. Trends are based on monthly mean ozone anomalies, and all sites have at least 20 years of data, which improves the likelihood that a robust trend value is due to changes in ozone precursor emissions and/or forced climate change rather than naturally occurring climate variability. Since 1995, the Northern Hemisphere sites are nearly evenly split between positive and negative ozone trends, while 5 of 7 Southern Hemisphere sites have positive trends. Positive trends are in the range of 0.5–2 ppbv decade–1, with ozone increasing at Mauna Loa by roughly 50% since the late 1950s. Two high elevation Alpine sites, discussed by previous assessments, exhibit decreasing ozone trends in contrast to the positive trend observed by IAGOS commercial aircraft in the European lower free-troposphere. The Alpine sites frequently sample polluted European boundary layer air, especially in summer, and can only be representative of lower free tropospheric ozone if the data are carefully filtered to avoid boundary layer air. The highly variable ozone trends at these 27 surface sites are not necessarily indicative of free tropospheric trends, which have been overwhelmingly positive since the mid-1990s, as shown by recent studies of ozonesonde and aircraft observations.
Rat postnatal prostate development is impaired by in vitro high-glucose environment
Authors: Cassimiro Isabella Silva , Cruz Amanda Rodrigues , Bosque Beatriz Pelegrini , de Melo Gomes Laura Calazans , Zanon Renata Graciele , da Costa Silva Jéssica Regina , Fujimura Patrícia Tieme , Ueira-Vieira Carlos , Ribeiro Daniele Lisboa
Published: June 2020

The prostate development has an important postnatal period where cell proliferation begins at the first days after birth and is related to gland growth and ramification. Any metabolic and/or hormonal changes occurring during the postnatal period can interfere with prostate branching. Hyperglycemia is a common condition in low-weight preterm babies at neonatal period and also a disorder found in the offspring of obese mothers. Thus, this study aimed to investigate the in vitro effects of a glucose-rich environment during prostate postnatal development. Wistar rats prostate were removed at birth and cultured for 1, 2 and 3 days in DMEM under normal (5.5 mM) or elevated (7 and 25 mM) glucose concentrations. Samples were processed for morphological analysis, PCNA and smooth muscle α-actin immunohistochemistry, evaluation of active caspase-3, ERK1/2 and Wnt5a gene expression. High glucose concentrations reduced the number of prostatic buds and proliferating cells. The natural increase in smooth muscle cells and collagen deposition observed in control prostates during the first 3 days of development was reduced by elevated glucose concentrations. The amount of active caspase-3 was higher in prostates incubated at 7 mM and TGF-β levels also increased sharply after both glucose concentrations. Additionally, high glucose environment decreased ERK 1/2 activation and increased Wnt5a expression. These data show that high levels of glucose during the first postnatal days affected prostate development by inhibiting cell proliferation which impairs bud branching and this was associated with anti-proliferative signals such as decreased ERK1/2 activation and increased Wnt5a expression.
Cyclophilin A plays an important role in embryo implantation through activating Stat3
Authors: Yu Tao , Lin Shuai , Xu Rui , Du Tian-Xi , Li Yang , Gao Hui , Diao Hong-Lu , Zhang Xiu-Hong
Published: June 2020

Embryo implantation is a crucial step for the successful establishment of mammalian pregnancy. Cyclophilin A (CYPA) is a ubiquitously expressed intracellular protein and is secreted in response to inflammatory stimuli to regulate diverse cellular functions. However, there are currently no reports about the role of CYPA in embryo implantation. Here, we examine the expression pattern of CYPA during mouse early pregnancy and explore the potential role of CYPA during implantation. CYPA is expressed in the subluminal stroma surrounding the implanting blastocyst on day 5 of pregnancy, but not at inter-implantation sites. In ovariectomized mice, estrogen and progesterone significantly stimulate CYPA expression. When pregnant mice are injected intraperitoneally with CYPA inhibitor, the numbers of implantation sites are significantly reduced. Using an in vitro stromal cell culture system, Ppia siRNA knockdown of CYPA and CYPA-specific inhibitor treatment partially inhibits levels of CD147, MMP3 and MMP9. Decreased CYPA expression also significantly inhibits Stat3 activity and expands estrogen responsiveness. Taken together, CYPA may play an important role during mouse embryo implantation.
НЕОЛІБЕРАЛЬНА МОДЕЛЬ РИНКУ ТА ЇЇ ВПЛИВ НА РОЗВИТОК УКРАЇНИ
Authors: ЄЩЕНКО Петро
Published: June 2020

Розкрито, що ліберальний мейнстрим, який репрезентує визначальний напрям у фундаментальній економічній теорії, в нинішніх умовах переходу від індустріально-ринкової до інформаційно-мережевої економіки та розвитку цифрових технологій не хоче залишати своє панівне місце. На основі фактичних даних показано негативний вплив цієї теорії, яка через здійснювану владними структурами України економічну політику, як буревій, руйнує не тільки економіку, а й культурні та соціальні цінності нашого народу. Нинішній соціально-економічний формат України не дозволяє їй боротися за «місце під сонцем» у розвитку цифрових технологій та перерозподілі технологічної ренти. Доведено, що використання неоліберальної економічної теорії сприяло тому, що світова економіка стала мати яскраво виражений рентний характер. Доказом цьому є те, що країни з низькоефективною економікою внаслідок відкриття національних економік мають світову ренту, що зменшується. Щодо країн з високорозвинутою економікою, то вони отримують світову ренту, що зростає.Обґрунтовується необхідність нової парадигми розвитку України. Радикальні зміни в нашій країні можуть відбутися за відмови від неоліберальної теорії та запровадження нової економічної політики, що базуватиметься на вимогах інформаційно-технологічної революції та адекватної їй економічній політиці, метою якої є розвиток та реалізація здібностей людини, а не гроші й прибуток. Дані питання мають велике теоретичне і практичне значення. Від них залежить майбутнє нашої країни, що вимагає пильної уваги вчених, зокрема представників суспільних наук.
ЗМІНА МОНЕТАРНИХ ПОЛІТИК ЦЕНТРОБАНКІВ ПРОВІДНИХ КРАЇН ТА ЇХ НАСЛІДКИ ДЛЯ КРАЇН З РИНКАМИ, ЩО РОЗВИВАЮТЬСЯ
Authors: БУБЛИК Євген
Published: June 2020

Досліджено особливості трансмісії чинників фінансової нестабільності для економік, що розвиваються, під впливом проявів згортання нетрадиційної монетарної політики в країнах економічного ядра. Відзначено, що такий вплив проявляється на ринках, що формуються, навіть на етапі очікувань через офіційні повідомлення. Основними факторами трансмісії негативного впливу є підвищення волатильності ПІІ та падіння цін на сировинних ринках.На етапі розгортання кількісного пом’якшення малі відкриті економіки накопичили значні обсяги ліквідності у вигляді портфельних і прямих іноземних інвестицій. Під впливом очікуваного підвищення процентних ставок у країнах економічного ядра зростають загрози відпливу капіталу з ринків економік, що розвиваються. На цьому етапі рух потоків капіталу прогнозувати набагато складніше, оскільки великою мірою його визначають короткострокові інструменти, поведінкові фактори та ринкові очікування. У цих умовах особливої актуальності набуває питання зміцнення інституційної спроможності монетарних регуляторів малих відкритих економік адекватно реагувати на швидкі зміни процесів.Не допускаючи надмірного обмеження фінансової і торговельної відкритості, регулятори повинні зосередити увагу на розвитку політик макропруденційного та валютного регулювання, а також комунікаційної політики. Сучасний інструментарій макропруденційного регулювання відкриває перспективи зміцнення пруденційної функції регуляторів з фокусуванням на ідентифікації чинників системного ризику та узгодженні політик щодо запобігання їм. На особливу увагу заслуговує розвиток валютного регулювання як необхідного механізму обмеження проциклічного руху міжнародного капіталу. Для України питання необхідності модернізації підходів до фінансової відкритості так само зумовлене високими ризиками проциклічного впливу міжнародних потоків капіталу з огляду на невизначеність перспектив процентних ставок. За таких умов політика фінансової лібералізації суперечить сучасним тенденціям монетарного регулювання і сприяє трансмісії волатильних МПК і монетарних шоків.
Mental Health Problems and Risk of Suicidal Ideation and Attempts in Adolescents
Authors: Orri Massimiliano , Scardera Sara , Perret Léa C. , Bolanis Despina , Temcheff Caroline , Séguin Jean R. , Boivin Michel , Turecki Gustavo , Tremblay Richard E. , Côté Sylvana M. , Geoffroy Marie-Claude
Published: June 2020

BACKGROUND:

Obtaining recent estimates of the prevalence of suicide-related outcomes across adolescence and its associated mental health problems (MHPs) is important for clinical practice. We estimated the prevalence of suicide-related outcomes at ages 13, 15, 17, and 20 years (2011–2018) in a contemporary population-based cohort and documented associations with MHPs throughout adolescence.

METHODS:

Data came from 1618 participants in the Québec Longitudinal Study of Child Development. Internalizing (depression and anxiety) and externalizing (oppositional/defiance, conduct issues, and attention deficit and/or hyperactivity) MHPs were assessed with validated questionnaires. Outcomes were self-reported past-year passive and serious suicidal ideation and suicide attempt.

RESULTS:

Lifetime prevalence of passive suicidal ideation (13–17 years old), serious suicidal ideation, and suicide attempt (13–20 years old) were 22.2%, 9.8%, and 6.7%, respectively. Prevalence was twice as high for females as for males. Overall, rates of passive (15–17 years old; 11.8%–18.4%) and serious ideation (13–20 years old; 3.3%–9.5%) increased over time but were stable for attempt (13–20 years old; 3.5%–3.8%). In univariable analyses, all MHPs were associated with suicide-related outcomes at all ages (risk rate ratio range: 2.57–3.10 [passive ideation] and 2.10–4.36 [suicide attempt]), and associations were similar for male and female participants (sex interaction P > .05). Magnitude of associations were generally stronger for more severe suicide-related outcomes (passive ideation < serious ideation < attempt). In multivariable analyses, internalizing problems were associated with suicidal ideation, whereas both depressive and conduct symptoms were associated with attempt.

CONCLUSIONS:

Suicidal ideation and attempt were common, especially for females and youth presenting with depressive and conduct problem symptoms. Clinicians should systematically assess suicidal risk in teenagers, especially in those presenting with MHPs.
Step-by-step Guide to Create Competency-Based Assignments as an Alternative for Traditional Summative Assessment
Authors: Amin Hebat Allah , Shehata Mohamed H. K. , Ahmed Samar A.
Published: June 2020

This article was migrated. The article was marked as recommended. The sudden, prolonged COVID-19 lockdown has offered a great challenge to the medical school. This was not only at the level of learning and curricular design but also the level of assessment. The traditional summative assessment tools have collapsed during this Pandemic.Herein, we provide a five-step guide for designing competency-based E-assignments for summative assessment. Innovative assignments designs are crucially required for fair summative assessment of the medical students, mainly in the pre-clerkship phase. These need to be innovative, engaging, competency-based, well-designed, with defined rubrics, integrated, and interdisciplinary whenever possible.These should also enforce the concepts of self-assessment and student peer assessment. Including the students in the formulation and design enhances their self-motivation where there is no face-to-face education. Designing an assignment with a quality product as an outcome increases the students' enthusiasm and self-confidence. A brief case-study is included as an example.Teaching after the pandemic era will greatly change with inevitable changes in the dogmatic concepts. Formative and summative assessments are probably changing seats which might be sustained for some time post-COVID-19.
A Fuzzy Logic Architecture for Rehabilitation Robotic Systems
Authors: Bouteraa Yassine , Ben Abdallah Ismail , ElMogy Ahmed , Ibrahim Atef , Tariq Usman , Ahmad Tariq
Published: June 2020

Robots are highly incorporated in rehabilitation in the last decade to compensate lost functions in disabled individuals. By controlling the rehabilitation robots from far, many benefits are achieved. These benefits include but not restricted to minimum hospital stays, decreasing cost, and increasing the level of care. The main goal of this work is to have an effective solution to take care of patients from far. Tackling the problem of the remote control of rehabilitation robots is undergoing and highly challenging. In this paper, a remote wrist rehabilitation system is presented. The developed system is a sophisticated robot ensuring the two wrist movements (Flexion /extension and abduction/adduction). Additionally, the proposed system provides a software interface enabling the physiotherapists to control the rehabilitation process remotely. The patient’s safety during the therapy is achieved through the integration of a fuzzy controller in the system control architecture. The fuzzy controller is employed to control the robot action according to the pain felt by the patient. By using fuzzy logic approach, the system can adapt effectively according to the patients’ conditions. The Queue Telemetry Transport Protocol (MQTT) is considered to overcome the latency during the human robot interaction. Based on a Kinect camera, the control technique is made gestural. The physiotherapist gestures are detected and transmitted to the software interface to be processed and be sent to the robot. The acquired measurements are recorded in a database that can be used later to monitor patient progress during the treatment protocol. The obtained experimental results show the effectiveness of the developed remote rehabilitation system.
Hesitant Fuzzy DeGroot Opinion Dynamics Model and Its Application in Multi-attribute Decision Making
Authors: Su Zhan , Xu Zeshui , Zhao Hua , Liu Shousheng
Published: June 2020

The research on the evolution law of the opinions can help the decision makers (DMs) improve the decision-making efficiency, predict the trend of events and make the right decision. These opinions are always described by one number, which is inaccurate and incomplete. To solve such a problem, in this paper, the hesitant fuzzy DeGroot (HF-DeGroot) opinion dynamics model is proposed. In order to simulate the transformation of hesitant fuzzy opinions, we introduced the multiplications for real matrix and hesitant fuzzy matrix. Then three kinds of transformation matrices with the consideration of the similarity degree, self-confidence degree and authority degree are constructed based on the hesitant fuzzy data and the consensus condition for the model is discussed as well. Furthermore, the HF-DeGroot opinion dynamics decision-making method is proposed from a prediction perspective and is applied to the emergency decision for the public health events. Finally, the effectiveness, feasibility and practicability of this method are shown by the comparison and simulation results.
LOS MONTÍCULOS COMO INDICADORES ARQUEOLÓGICOS DE LA SACRALIDAD DE LOS SEÑORÍOS CAÑARIS
Authors: Veriñez Mary Beatriz Jadán
Published: June 2020

Aunque la etnohistoria presenta abundante información respecto a los pueblos locales, la arqueología no ha logrado definir suficientemente en su materialidad a la sociedad cañari. Al abordar esta investigación se proyecta contribuir al estudio de los montículos de tierra o plataformas ubicadas en las cumbres de las montañas y los cerros coronados con piedras emplazados en la región centro sur y sur andina del Ecuador. Mediante el rastreo bibliográfico y utilizando los métodos analítico, sintético y empírico, se ubican estos contextos arqueológicos y se les compara con la información etnohistórica de los pueblos locales. Se analizan, además, los contextos arqueológicos encontrados en los sitios Cerro Puñay y Guiñayzhu. Como resultado, se detecta una recurrencia de estos vestigios en la región adscrita a los cañaris prehispánicos y se considera que todas estas evidencias están relacionadas con los rituales de los cerros, por lo que resulta importante su conocimiento para el fortalecimiento de la cultura e identidad andina.
La historieta como recurso didáctico para promover el cuidado de la cavidad bucal en niños
Authors: Alzamora De La Rosa Leslie Esther , Orozco Páez Jennifer , Plazas Román Jaime Enrique
Published: June 2020

Introducción: la educación para la salud abarca una serie de herramientas de aprendizaje que ayudan a modificar las conductas relacionadas con el bienestar de las personas. La historieta es un medio de comunicación aceptado por diferentes grupos etarios, en especial por los niños y adolescentes, lo que sugiere que puede ser probada como una herramienta de enseñanza. Evaluar el uso de la historieta para promover el cuidado de la cavidad oral en pacientes pediátricos de 6 a 10 años que asisten a la escuela deportiva de la Fundación Granitos de Paz de Cartagena.

Materiales y métodos: se realizó un estudio cuasi experimental en el que se conformaron dos grupos de estudio a los que previamente se les aplicó un test sobre autocuidado de la cavidad bucal para posteriormente realizar enseñanza en salud oral, con el grupo control se utilizaron técnicas educativas basadas en charlas y demostraciones, mientras que el grupo de estudio recibió educación en salud a través de una historieta, los conocimientos adquiridos se evaluaron aplicando un test.

Resultados y conclusiones: los resultados del pretest no fueron satisfactorios para ninguno de los dos grupos de estudio. Una vez aplicadas las técnicas de educación en salud oral los resultados del postest mostraron que el 76 % de los niños que fueron educados con historieta presentaron una calificación excelente, mientras que solo el 28 % de los niños educados con estrategias convencionales recibieron esta valoración. Los resultados positivos ponen de manifiesto que la historieta tuvo buena aceptación y promovió la asimilación de conocimientos acerca del cuidado de la salud bucal en los niños.
Ebeveynlerin Alerjik Astım Nedenleri Hakkındaki Bilgi Düzeylerinin ve Uygulanan Tedaviye Yaklaşımlarının Değerlendirilmesi
Authors: ATLA Pınar , ERGENEKON Pınar , ERDEDE Özlem , SARI Erdal , SARİCOBAN Hulya
Published: June 2020

GİRİŞ-AMAÇ: Astım, çeşitli uyaranlara karşı gelişen hava yolu aşırı duyarlılığı ile ilişkili kronik hava yolu inflamasyonu ile karakterize bir hastalıktır. Kötü kontrollü astımın önemli belirleyicilerinden bazıları evdeki evcil hayvanlar, hava kirliliği, polen maruziyeti gibi çevresel faktörlerdir. Çalışmamızda ebeveynlerin astımı ortaya çıkaran etkenler, ataklardan korunmak için alınabilecek önlemler ve astım için ilaç kullanımı hakkındaki bilgi düzeylerini ölçmeyi amaçladık. MATERYAL-METOD: Ocak 2015 -Haziran 2016 tarihleri arasında Zeynep Kamil Hastanesi hasta çocuk polikliniğine herhangi bir nedenle başvuran hasta yakınlarına astım bilgi düzeyini ölçmeyi hedeflediğimiz anket formu uygulandı. Ankette hasta ve hasta yakınlarının demografik özelliklerinin yanısıra alerjik hastalık/astım varlığı, varsa astım için kullanılan ilaçlar , alerjik astımı ortaya çıkaran etkenler ve astımdan korunmak için alınabilecek önlemler sorgulandı. Hasta yakınları etkenler ve önlemler için birden fazla cevaplama yapabildiler. BULGULAR: Çalışmaya yaşları 20-49 arasında, 781 kadın ve 219 erkek olmak üzere toplam 1000 hasta yakını dahil edildi. Hastaların ortalama yaşları 4,5 ± 2,2 yıl idi. Çalışmaya dahil edilen ebeveynlerin 169’unda alerjik hastalık mevcutken, 61 ebeveyn astım nedeniyle inhaler tedavi kullanmaktaydı. Çocuğunda alerjik hastalık olanların sayısı 149 idi. Astım/alerjik bronşit olan 114 hastanın 74’ü erkek olup ortalama yaşı 4,4 ± 3,06 yıl idi. Astımı ortaya çıkardığı düşünülen etkenler sorusuna en sık (%50,1) bilmiyorum cevabı verilirken; çocuğu astımdan korumak için alabilecekleri önlemler sorusuna da en sık (%52) bilmiyorum cevabı verildi. Çocuğunda alerjik hastalığı olanlarda çocuğunda alerjik hastalığı olmayanlara göre astım ataklarının ev tozu, polen, rutubet, evcil hayvan, kirli hava, sigara, küf ve gıdadan kaynaklı olduğunu düşünenlerin oranları istatistiksel olarak anlamlı derecede daha yüksek ve bu soruya bilmiyorum cevabı verenlerin oranı istatistiksel olarak anlamlı derecede daha düşüktü (p˂0,001). SONUÇ: Çocuğunda alerjik hastalık mevcut olan hasta yakınlarının alerjik astımı ortaya çıkaran etkenler ve astımdan koruyucu önlemler konusunda bilgi düzeyleri diğer hasta yakınlarına kıyasla daha yüksektir. Ancak tüm çalışmadaki ebeveynler değerlendirildiğinde astım etkenleri ve koruyucu önlemler sorularına verilen “bilmiyorum” cevabının fazlalığı bilgi düzeyinin yeterli olmadığını göstermektedir. Ebeveynler havayolu hassasiyeti olan çocukları için çoğunlukla alerjik bronşit tanımını kullanmayı seçmişlerdi. Astım tanısı aileler için belki de ürkütücü, tedavisi zor , kronik bir hastalık olarak düşünüldüğünden bu tanımlamayı daha az tercih etmişlerdi. Astım tedavisi ve kontrolü için ebeveynlerin bilgi düzeyinin artırılması gerekmektedir.
Old, disabled, successful?
Authors: Rickli Francesca
Published: June 2020

Aging – both the definition and the actual process of aging – has undergone fundamental local and global changes in the past decades. Various advances in technology and medicine increasingly allow senior citizens in Switzerland to ‘age successfully’ and have shifted societal expectations about what aging should include. This article looks at a group of senior citizens who encounter an increasing discrepancy between the demands fostered by the dominant discourse of ‘successful aging’ and the infrastructure made available to them. At the same time, seniors with disabilities are transfigured and come to stand for dependence, frailty, and decline because of this reconceptualization of aging. This article analyzes the cases of three senior citizens with disabilities which show the consequences of changed normative imaginaries, practices, and infrastructures on how senior citizens with disabilities experience their socialities
Rethinking sociality and health through transfiguration
Authors: Hadolt Bernhard , Obrist Brigit , Mattes Dominik
Published: June 2020

In this introductory article to the Special Section, we intend to literally bring sociality to (bodily) life and ask what medical anthropology might gain by using the lens of sociality for a better understanding of the phenomena it is concerned with. Conversely, we probe how the field of health and illness – including themes concerning embodiment, vulnerability, suffering, and death – might help to further spell out the notion of sociality both conceptually and methodologically. Drawing on the contributors’ ethnographic enquiries into contemporary health phenomena in East Africa, South America, and Western Europe, we do so by bringing sociality into conversation with transfiguration. By this we refer to: (1) the constantly unfolding processes of particular extended figurations encountering, affecting, and becoming enmeshed in each other; as well as (2) the (temporarily) stabilized figurational arrangements emerging from these enmeshments. It is our hope that this notion of transfiguration will help render visible the modalities through which human engagements with each other and the world form diverse arrangements. Moreover, we aim to better understand the processes by which these arrangements – which we term ‘extended figurations’ – interact with each other, change over time, and possibly vanish and make way for others. A detailed appreciation of the workings of these extended figurations, we believe, can significantly enhance our comprehension of the particular processes of change that stand at the center of our ethnographic interest. In this sense, the concept of transfiguration constitutes one possible way of structuring the messiness and complexity of sociality for analytical purposes.
My test protocol v1
Authors: Hrynaszkiewicz Iain
Published: June 2020

This is a test protocol for DOI versioning test
METODE PENGEMBANGAN KETERAMPILAN BERCERITA YANG BERKARAKTER UNTUK PENDIDIKAN ANAK USIA DINI
Authors: Rohayati Etty
Published: June 2020

Sebagaimana diketahui bahwa setiap kegiatan pembelajaran yang akan dilaksanakan tidak terlepas dari metode dan strategi pembelajaran. Metode itu suatu prosedur pelaksanaan kegiatan dalam pengembangan atau pembelajaran. Dalam kaitannya dengan pendidikan anak usia dini, salah satu metode yang dapat digunakan adalah metode bercerita. Bercerita adalah suatu kegiatan yang dilakukan seseorang secara lisan kepada orang lain dengan alat atau tanpa alat, umumnyayang disampaikan penutur dalam bentuk pesan, informasi. Begitu juga cerita anak-anak disampaikan pada sebuah dongeng untuk didengarkan dengan rasa menyenangkan. Dalam menyampaikan cerita dongeng seorang guru harus mampu menyajikannya secara menarik dan ekspresi yang meyakinkan. Sejalan dengan hal tersebut, guru PAUD harus mampu menguasai metode bercerita secara mendalam agar mampu melaksanakan pembelajaran dengan menggunakan metode mendongeng secara tepat guna, tetap sasaran, dan tepat tujuan.
LEARNING ENGLISH THROUGH STORY, SONG AND PLAYING
Authors: Ananthi Winti
Published: June 2020

Banyak lembaga PAUD, baik formal, nonformal, dan informal, yang telah memperkenalkan bahasa Inggris di lembaganya. Namun sayangnya, banyak lembaga tersebut yang mengenalkan bahasa Inggris hanya dengan memberikan kosakata bahasa Inggris dan padanannya dalam bahasa Indonesia sehingga pengenalan bahasa Inggris di PAUD menjadi kurang bermakna. Agar lebih bermakna, sebaiknya pengenalan bahasa Inggris memperhatikan prinsip-prinsip PAUD yang telah dikemukakan sebelumnya. Belajar bahasa Inggris melalui Story, Songdan Playing diharapkan dapat memenuhi prinsip-rinsip PAUD yang telah diinstruksikan oleh pemerintah. Pengenalan bahasa Inggris melalui Story, Songdan Playingdiharapkan dapat meningkat kemampuan bahasa Inggrisnya dan sekaligus diharapkan anak usia dini dapat mengembangkan sikap toleransi dan cinta damai, hormat terhadap orang lain yang mempunyai latar belakang budaya yang berbeda, dan juga dapat menumbuhkan rasa cinta terhadap tanah air.
PAMUK TELEFİNDEN VİSKOZ RAYON ÜRETİMİ
Authors: TÜRKOĞLU Sami , TUTUŞ Ahmet , ÇİÇEKLER Mustafa
Published: June 2020

Viskoz rayon lifleri saflaştırılmış selülozdan elde edilen ve ülkemizde yılda yaklaşık 250 bin ton civarında tüketilen, 1.5 milyar dolarlık ithalatı yapılan önemli bir üründür. Viskoz rayon lifleri doğal ve yenilenebilir kaynaklardan elde edilmekte olup üretiminde her geçen gün tükenmekte olan petrol kaynakları yerine doğal materyallerin kullanılması hem çevresel hem de ekonomik anlamda önemli avantajlar sunmaktadır. Pamuk liflerinin %96’lık kısmı saf selülozdan oluşmaktadır. Bu çalışmada, pamuk teleflerinden standartlara bağlı kalınarak α-selüloz(alfa selüloz-saf selüloz) polimerleri elde edilmiş olup daha sonra yaş lif çekim yöntemiyle α-selülozdan %93 verimde rejenere viskoz rayon lifleri üretilmiştir. Elde edilen viskoz rayon liflerinin yurt dışından ithal edilen viskoz rayon liflerinin özelliklerine benzer değerler taşıdığı tespit edilmiştir. Genel olarak atılmakta olan bu hammadde kaynağı ile yüksek verimli ve yüksek katma değerli yeni ürün elde edilmiştir.
Magazin Haberlerinin Okurların Tüketim Alışkanlığı Üzerindeki Etkileri
Authors: BEGTİMUR Mehmet Emin , MAZICI Nurşen
Published: June 2020

İletişim alanında, kitle iletişim araçlarının etkilerini ölçmeye yönelik araştırmalar neredeyse yüzyıl önce başlamıştır. Bu süreçte, farklı araştırmacı ve kurumlar tarafından farklı metotlarla etki araştırmaları yapılmış ve araştırma sonuçları da farklı amaçlar için kullanılmıştır. İlk başlarda gerçekleştirilen etki araştırmalarında siyasi haberlerin etkilerine odaklanılmışken, zamanla şiddet ve ekonomi haberlerinin okur üzerindeki etkileri de araştırma konusu olmuştur. Kitle iletişim araçlarında politika, ekonomi ve şiddet haberlerinden sonra büyük bir öneme sahip olan magazin haberleri, gerek gazetecilerin gerekse medya kuruluşlarının vazgeçilmezidir. Siyasi baskı, kârı arttırma ve kolay olanı yakalama gibi nedenlerden dolayı magazin içerikli haber ve programlar yaygınlık kazanmaktadır. Bu çalışmada, kitle iletişim araçlarında büyük bir yer tutan magazin haberlerinin, özellikle de internet gazetelerindeki magazin haberlerinin okurların tüketim alışkanlığıyla ilgili tutum ve davranışları üzerindeki etkilerine odaklanılmıştır. Anket araştırması yöntemiyle gerçekleştirilen bu çalışma, magazin haberlerinin okurların tüketim alışkanlığı üzerinde orta düzeye bir etkiye sahip olduğu sonucunu ortaya koymuştur.
Kültürel Diplomasi ve Kore Dalgası “Hallyu” Güney Kore’de Sinema Endüstrisi, K-Dramalar ve K-Pop
Authors: BOZ Nevfel
Published: June 2020

Mutlu Binark’ın kaleme aldığı “Kültürel Diplomasi ve Kore Dalgası “Hallyu” Güney Kore’de Sinema Endüstrisi, K-Dramalar ve K-Pop” isimli eser, kültürel içeriklerin bir kültürel diplomasi unsuru olarak kullanılmasının yanı sıra son dönemde iletişim araştırmalarının ilgi odağı olmaya başlayan Kore Dalgası konusunda kuramsal bilgi ve içerik üretim alanlarından örnekler sunması dolayısıyla öne çıkmaktadır., Çalışmayı önemli kılan bir diğer husus da yazarının, Türkiye’de iletişim alanında önemli bir konuma sahip olmasıdır. İletişim kuramları, iletişim sosyolojisi, eleştirel medya okuryazarlığı ve yeni medya çalışma alanlarında bir dizi kıymetli çalışmaya imza atan Binark, bu çalışmasında ise Kore Dalgası (Hallyu) olarak adlandırılan kültürel içeriklerin bir kültürel diplomasi aracı olarak Kore devleti tarafından ve bir devlet politikası olarak üretiminin yapılması ve yayılımının sağlanması konusunda nasıl desteklendiğine odaklanmaktadır
Wychowawcze implikacje czarownicy - niezwykłej kobiety - w świetle założeń pedagogiki emancypacyjnej
Authors: Symonowicz-Jabłońska Izabela
Published: June 2020

Rozważania nad czarownicą-kobietą, wpisujące się w myśl założeń pedagogiki emancypacyjnej, mają ukazać modyfikację jej dotychczasowego wizerunku, otworzyć nową możliwość badawczą, która pozwoli na szersze spojrzenie na czarownicę – jako tłumaczkę kultury, niewpisującą się w główny, centralistyczny nurt myślenia o świecie. Zatem czy postać czarownicy-kobiety, widziana w podstawowych, stereotypowych konstrukcjach myślowych człowieka, jako postać destrukcyjna i złośliwa, która zawsze reprezentuje przeciwieństwo wszystkich pozytywnych wartości, może być postacią pozytywną? Czy „działa dwojako, będąc mitem, jest zarazem prawdą i złudzeniem” (Rella 2003, s. 295)? Czy obraz czarownicy zmienia się wraz z wiekiem dorastającego człowieka? Wartością dodaną artykułu są wyniki badań przeprowadzonych wśród młodzieży liceum ogólnokształcącego w Toruniu. Dzięki zastosowaniu badania wyjaśniającego powstał inwentarz cech definiujących czarownicę. Badaniem objęto 26 osób (13 z klasy o profilu humanistycznym i 13 z klasy o profilu matematyczno-informatycznym), aby określić różnice w zakresie werbalizowanych wartości między dwiema grupami profilowymi.
Anos cincuenta no Val do Salnés
Authors: Baliñas Fernández Carlos
Published: June 2020

Anos cincuenta no Val do Salnés: crónica dun tempo, de amizade e da traxectoria profesional de Herminio Barreiro e  o profesor Carlos Baliñas Fernández.
Herminio en Compostela. Pedagoxía e cordialidade
Authors: Santos Rego Miguel Anxo
Published: June 2020

Testemuño persoal de agradecemento que pon en valor a cordialidade e xenerosidade intelectual do profesor Herminio Barreiro dentro e fóra das aulas.
Brais Pinto como autoaprendizaxe
Authors: Barreiro Rodríguez Herminio
Published: June 2020

Texto de Herminio Barreiro sobre o grupo Brais Pinto, publicado en 2011.
Refundar a educación para refundar a esquerda
Authors: Barreiro Rodríguez Herminio
Published: June 2020

Texto de Herminio Barreiro sobre la refundación de la educación y de la izquierda, publicado en 2010.
Herminio Barreiro: la educación como diálogo
Authors: Borrajo Borrajo Gena
Published: June 2020

Entrevista realizada por Gena Borrajo al profesor Herminio Barreiro en el año 2005, y que se publicó en el número 347 de la revista Cuadernos de Pedagogía.
The Marshall-Olkin Extended Power Lomax Distribution with Applications
Authors: GILLARIOSE JIJU , Tomy Lishamol
Published: June 2020

In this article, we dened a new four-parameter model called Marshall-Olkin extended power Lomax distribution and studied its properties. Limiting distributions of sample maxima and sample minima are derived. The reliability of a system when both stress and strength follows the new distribution is discussed and associated characteristics are computed for simulated data. Finally, utilizing maximum likelihood estimation, the goodness of the distribution is tested for real data.
Effects on lubricating oil and piston rings of the different operating parameters in a DI diesel engine
Authors: TEMİZER İlker , CİHAN Ömer
Published: June 2020

Biodiesel is an alternative fuel that can be produced from renewable sources such as vegetable and animal fats. It is available as fuel in diesel engines. Also, biodiesel fuel is a type of environmentally friendly fuel that is non-toxic, not perishable in nature. A single cylinder, four-stroke, air-cooled, direct-injection diesel engine was used in the study. In the engine is used as fuel of diesel fuel and 10%, COME (Canola Oil Methyl Ester) was added to diesel fuel.The piston rings between the engine parts are critical in term of leakage and lubrication. The fuel used affects engine performance and emissions as well as the surface structure of the piston rings. In this study, Antor 3LD510 diesel engine was run with 10% canola oil methyl ester blended fuel and the engine carried out subjected to long term 150 hours’ endurance test. The engine was operated at 1500 rpm and under part load. SEM (Scanning Electron Microscope) and EDX (Energy Dispersive Spectrometry) analysis of the first, second and third piston rings were performed. As a result, after the operation of the engine with both fuels, the Cr element was largely determined on the surface of the first piston ring and the structure was not disturbed. When the second piston ring surface distribution of COME10 fuel compared to diesel fuel is examined, it is seen that besides the wear elements, combustion and fuel chemistry in the engine are more effective on the surface. The surface of the third piston ring was found to be close to each other after the operating of engine.
DEPÓSITOS DE QUARTZO AMETISTA EM MINAS GERAIS
Authors: Dias Coralie H. , Chaves Mario L. S. C. , Figueiredo e Silva Rosaline C.
Published: June 2020

Em Minas Gerais, o quartzo ametista ocorre em diferentes ambientes geológicos de formação. O presente trabalho apresenta uma revisão do conhecimento acerca destas ocorrências e depósitos. Ametistas em cavidades de basaltos se restringem no Estado à região do Triângulo Mineiro. As cavidades preenchidas são presentes na porção superior do nível central de derrames, contendo, além de quartzo, minerais tipicamente formados em baixas temperaturas como argilominerais e calcita. Os depósitos em veios hidrotermais relacionam-se principalmente ao contexto geológico da Serra do Espinhaço e adjacências a leste e possuem provável idade Brasiliana, representando os maiores volumes em termos de produção e pesquisas relacionadas. Nestes, a ametista associa-se principalmente a quartzo hialino ou leitoso e óxidos de ferro. Em pegmatitos, a ametista não é muito comum, embora existam informações de ocorrências próximas a Teóﬁlo Otoni, além da ocorrência estudada em Pancas (ES). Estas situam-se no contexto da Província Pegmatítica Oriental do Brasil, relacionadas a pegmatitos não zonados e pouco diferenciados, contendo quartzo, feldspato e muscovita, além de apatita, crisoberilo e água-marinha.

Palavras-Chave: Ametista, Depósitos Minerais, Minas Gerais.
RELAÇÃO HIDRÁULICA ENTRE O COMPLEXO BELO HORIZONTE E O GRUPO BAMBUÍ NA PORÇÃO SUL DA APA CARSTE DE LAGOA SANTA, MG
Authors: Andrade Isabella B. , Barbosa Jéssica A. , Ribeiro Carolina G. , Paula Rodrigo S. , Velasquez Leila N. M.
Published: June 2020

A área desse estudo situa-se ao norte da cidade de Belo Horizonte, Minas Gerais, possui 432 km² e intersecciona parcialmente a porção sul da Área de Proteção Ambiental Federal (APA) Carste de Lagoa Santa. A porção basal é geologicamente caracterizada por granodioritos, granitos e gnaisses que deﬁnem as rochas do Complexo Belo Horizonte. Sobreposto a essa unidade por contato tectônico, estão as coberturas neoproterozoicas do Grupo Bambuí, que dá base para o topo constituam-se, pela Fm. Sete Lagoas, composta por metacalcários, e Fm. Serra de Santa Helena, constituída por metapelitos foliados. Lineamentos fotointerpretados associados com estruturas mensuradas em campo e dados hidráulicos de poços tubulares foram utilizados para a determinação do ﬂuxo subterrâneo entre as rochas do Complexo Belo Horizonte e a Formação Sete Lagoas. A partir dos dados de capacidade especíﬁca obteve-se que a direção NE é tita como preferencial para transferência de ﬂuxo d'água das fraturas do embasamento cristalino para as rochas supracrustais do Grupo Bambuí, de onde o ﬂuxo segue preferencialmente na direção EW. Entretanto, os dados hidráulicos de produtividade levantados mostram que as faixas produtivas nas rochas carbonáticas se orientam preferencialmente nas direções N60-90E e N60-90W.

Palavras-Chave: Apa carste de lagoa santa; hidrogeologia; produtividade poços tubulares
Coincidence of 3-methylglutaconic aciduria and duplication 5q – a case report and literature review
Authors: Zapolnik Paweł , Sykut-Cegielska Jolanta , Pyrkosz Antoni
Published: June 2020

3-methylglutaconic aciduria includes a heterogeneous group of inborn errors of metabolism. The disease may have various clinical presentations, as can duplication 5q. We present the case of a 13-year-old boy with 3-methylglutaconic aciduria and duplication 5q. The main symptoms included myopathy, weakness, spastic paresis intensified mostly in the lower limbs, and intellectual disability. Additional studies showed elevated levels of 3-methylglutaconic acid in urine and ammonia in plasma. A duplication in region 5q23.3q31.1 was found in array-based comparative genomic hybridization. Next-generation sequencing did not reveal any pathological mutation. On the basis of the clinical picture and the results of biochemical and genetic tests 3-methylglutaconic aciduria type IV with duplication 5q was diagnosed.
Medical Tourism in Iran, Reevaluation on the New Trends: A Narrative Review
Authors: ROKNI Ladan , PARK Sam-Hun
Published: June 2020

Background: This narrative review aimed to reevaluate the medical tourism sector in Iran to reveal the new trends and activities in order to know the current actual share of Iran in the competitive market of global medical tourism.
Methods: A holistic approach was adopted to analyze the information collected through a system of investigation that comprised the available secondary data, besides the information and statistical data about the associated organizations to this sector in Iran.
Results: Iran’s medical tourism sector is consistent with the new trends in global market, which is mainly bordered countries-based, cultural-oriented, and diasporic type of travelling.
Conclusion: It would be more realistic in the contemporary situation to focus the promotions on the border countries, and design the policy, and implementation in accordance with their cultural and social preferences. Activities in both levels of governmental and micro-level planning are demanded, under the cover of a comprehensive monitoring system. This review will benefit researchers exploring the updated evaluation of Iran’s medical tourism; also, it provides helpful insights to authorities in both governmental and private sector.
Association of MMP-2 -753C>T and MMP-9 -1562C>T Polymorphisms with Chronic/Aggressive Periodontitis Risk: A Systematic Review and Meta-Analysis
Authors: MASHHADIABBAS Fatemeh , NEAMATZADEH Hossein , FOROUGHI Elnaz , DASTGHEIB Seyed Alireza , FARAHNAK Soudabeh , NASIRI Rezvan , AHMADI Shima
Published: June 2020

Background: Two functional polymorphisms in the matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9) genes may contribute to periodontitis pathogenesis. However, the results were inconsistent and inconclusive. Therefore, to clarify precise associations of MMP-2 -753 C>T and MMP-9 -1562C>T polymorphisms with chronic (CP) and aggressive (AgP) periodontitis, we performed a systematic review and meta-analysis.
Methods: A literature search was conducted using PubMed, Google Scholar, Embase, and Web of Science databases until 5 July 2017. The data were analyzed with CMA software, and risk estimates are expressed as odds ratios (ORs) and 95% confidence intervals (95% CIs).
Results: Nineteen case-control studies in ten publications with 2089 periodontitis cases and 2345 controls met the criteria. The pooled ORs indicated that MMP-2 -753C>T and MMP-9 -1562C>T polymorphisms were not significantly associated with risk of periodontitis in overall analysis. Stratified analyses by ethnicity and periodontitis type indicated that the MMP-9 -1562C>T polymorphism showed a significant association with the risk of periodontitis among Caucasians and CP/AgP subgroup, whereas MMP-2 -753C>T polymorphism was significantly associated with periodontitis risk only among Asians.
Conclusion: MMP-2 -753C>T and MMP-9 -1562C>T polymorphisms may not be associated with risk of periodontitis in overall population. However, MMP-2 -753C>T and MMP-9 -1562C>T polymorphisms might have influence on the susceptibility of periodontitis by ethnicity.
Mechanism of Probiotic VSL#3 Inhibiting NF-κB and TNF-α on Colitis through TLR4-NF-κB Signal Pathway
Authors: WANG Hui , LI Shuhua , LI Houzhong , DU Fengxia , GUAN Jie , WU Yanmin
Published: June 2020

Background: We aimed to investigate the effect of probiotic VSL#3 on NF-κB and TNF-α in rats with colitis and the correlation with TLR4-NF-κB signal pathway.
Methods: Sixty Sprague Dawley (SD) rats were divided into the control, model and therapy groups (n=20) according to the random number table. Rats in the model and therapy groups were modeled for colitis, and rats in the therapy group were intragastrically administered with probiotic VSL#3. The expression of TLR4 and NF-κB protein, and the levels of NF-κB, TLR4, and TNF-α mRNA in the colon tissue were detected. The concentration of TNF-α in the serum after modeling but before intragastric administration (T0), 3d (T1) and 7d after intragastric administration (T2) was detected.
Results: The expression of TLR4 and NF-κB p65 protein, and the levels of TLR4, NF-κB, and TNF-α mRAN in the therapy group decreased (P < 0.001). At T0, T1, and T2, the concentration of TNF-α in the model and control groups increased (P < 0.001). TLR4 and NF-κB in the therapy group were positively correlated with TNF-α mRAN (P < 0.050).Conclusion: In conclusion, probiotic VSL#3 inhibits the expression of NF-κB and TNF-α in rats with colitis through TLR4-NF-κB signal pathway, so it is expected to be a first choice drug for the treatment of colitis.
Conclusion: In conclusion, probiotic VSL#3 inhibits the expression of NF-κB and TNF-α in rats with colitis through TLR4-NF-κB signal pathway, so it is expected to be a first choice drug for the treatment of colitis.
Augmented cAMP Signaling by Co-Administration of Resvera-trol and Curcumin: A Cellular Biosensor Kinetic Assessment
Authors: SAFAVIFAR Farnaz , SAADAT Farshid , JALALI Seyedeh Zohreh , KHORAMIZADEH Mohammad Reza
Published: June 2020

Background: Curcumin and resveratrol are two polyphenolic compounds extensively investigated for their medicinal effects on inflammatory signaling. However, there is a paucity of information on the Adenosine-3’, 5’-cyclic monophosphate (cAMP) kinetics following administration of curcumin and resveratrol in biological systems. In this study, kinetic modulation of cAMP as a target detection messenger in pro-inflammatory pathways was assessed by co-administration of curcumin and resveratrol using a cellular sensor model.
Methods: To evaluate their putative activity, curcumin and resveratrol compounds were administered alone or in combination on the media culture of cAMP EPAC (exchange protein directly activated by cAMP) bioluminescence resonance energy transfer (BRET) biosensor. The study was performed at the following two centers at Tehran University of Medical Sciences (TUMS):  1- Biotechnology Research Center, and, 2- Endocrinology and Metabolism Research Institute (EMRI) in 2017. Time course kinetic of cAMP response signals were plotted. Forskolin and IBMX were used to stabilize the cAMP signals.
Results: When we treated HEK-293T biosensor cells at 10uM concentration, curcumin and resveratrol upregulated cAMP signaling. Co-administration of resveratrol and curcumin revealed an augmented cAMP level, as compared to treatments with the compounds alone.
Conclusion: Co-administration of curcumin and resveratrol leverage cAMP kinetic response in a time-course manner. The presented methodology can be readily adopted for drug development and novel biopharmaceutical functional analyses.