bluuebunny/crossref_metadata_2025 huggingface dataset:
A Hybrid Remaining Useful Life Prediction Method for Cutting Tool Considering the Wear State
Authors: Li Yifan , Xiang Yongyong , Pan Baisong , Shi Luojie
Published: January 2022

Accurate cutting tool remaining useful life (RUL) prediction is of significance to guarantee the cutting quality and minimize the production cost. Recently, physics-based and data-driven methods have been widely used in the tool RUL prediction. The physics-based approaches may not accurately describe the time-varying wear process due to a lack of knowledge for underlying physics and simplifications involved in physical models, while the data-driven methods may be easily affected by the quantity and quality of data. To overcome the drawbacks of these two approaches, a hybrid prognostics framework considering tool wear state is developed to achieve an accurate prediction. Firstly, the mapping relationship between the sensor signal and tool wear is established by support vector regression (SVR). Then, the tool wear statuses are recognized by support vector machine (SVM) and the results are put into a Bayesian framework as prior information. Thirdly, based on the constructed Bayesian framework, parameters of the tool wear model are updated iteratively by the sliding time window and particle filter algorithm. Finally, the tool wear state space and RUL can be predicted accordingly using the updating tool wear model. The validity of the proposed method is demonstrated by a high-speed machine tool experiment. The results show that the presented approach can effectively reduce the uncertainty of tool wear state estimation and improve the accuracy of RUL prediction.
Anomalous Thermo-osmotic Conversion Performance of Ionic Covalent-Organic-Framework Membranes in Response to Charge Variations
Authors: Sun Qi , Xian Weipeng , Zuo Xiuhui , Zhu Changjia , Guo Qing , Qing Qing-Wei , Zhu Xincheng , Wang Sai , Ma Shengqian
Published: January 2022

The development of efficient thermo-osmotic energy conversion devices has fascinated scientists and engineers for several decades in terms of satisfying the growing energy demand. The fabrication of ionic membranes with a high charge population is known to be a critical factor in the design of high-performance power generators for achieving high permselectivity and, consequently, high power extraction efficiency. Herein, we experimentally demonstrated that the thermo-osmotic energy conversion efficiency was improved by increasing the membrane charge density; however, this enhancement occurred only within a narrow window and subsequently exhibited a plateau over a threshold density. The complex interplay between pore−pore interactions and fluid structuration for ion transport across the upscaled nanoporous membranes helped explain the obtained results with the aid of numerical simulations. Consequently, the power generation efficiency of the multipore membrane deteriorated, deviating considerably from the case of simple linear extrapolation of the behavior of the single-pore counterparts. A plateau in the output electric power was observed at a moderate charge density, affording a value of 210 W m−2 at a 50-fold salinity difference with a temperature gradient of 40 K. This study has far-reaching implications for discerning an optimal range of membrane charge populations for augmenting the energy extraction, rather than intuitively focusing on achieving high densities.
Impact of COVID19 Forced Confinement for CO2 Emission, NO2 Concentration, and Traffic Congestion Throughout EU Nations and United Kingdom (UK)
Authors: Sahraei Mohammad Ali , Ziaei Babak
Published: January 2022

The coronavirus outbreak has led several cities to come to the standstill and country lockdown within several locations to reduce coronavirus spread. Here we investigate CO2 emission, NO2 concentration, and mobility throughout EU nations and the United Kingdom (UK) from January 2019 until the end of August 2021. In accordance with the previous research obtained by Liu et al. and Le Quéré et al., as mentioned in the literature, our results show a reduction of CO2 emission for an extended period of 2020 and 2021 compared to the annual emission in 2019. This work obtained abrupt reductions of 10.66% and 4.36% in 2020 and 2021, respectively. Although the ratios and relationship between CO2 and NO2 were considered, we found that monthly NO2 concentration was reduced by 2–39% for ±1σ in 2020 and 13–34% for ±1σ in 2021 (until August) relative to 2019. Additionally, during confinements, the average annual mobility was substantially reduced by 36% for 2020 and 24% for 2021 (until August) relative to 2019. By discussing the role of distinct countries, the current study can contribute to comprehending the role of coronavirus as a huge disruptive factor in socio-economic activities, air quality, and city mobility.
Ex-Press® Surgery Versus Trabeculectomy for Primary Open Angle Glaucoma with Low Preoperative Intraocular Pressure
Authors: Otsuka Mitsuya , Hayashi Atsushi , Tojo Naoki
Published: January 2022

Purpose: To compare surgical outcomes between Ex-PRESS® surgery (EXP) and trabeculectomy (Trab) for primary open angle glaucoma (POAG) with low preoperative intraocular pressure (IOP).Patients and Methods: This was a retrospective non-randomized study. We included POAG patients with preoperative IOP ≤16 mmHg who were taking tolerance glaucoma medications. We compared the surgical outcomes, postoperative IOP, number of glaucoma medications, reduction rate of corneal endothelial cell density (ECD), visual acuity, and postoperative complications between POAG patients who underwent EXP (34 eyes) or Trab (38 eyes) and could be followed for >2 years.Results: Both surgeries significantly decreased the IOP (p<0.001): at 2 years, EXP provided decreases from 13.4 ± 2.3 to 10.2 ± 3.1 mmHg, Trab provided decreases from 13.5 ± 2.0 to 8.9 ± 3.2 mmHg. No significant differences were observed in the postoperative IOP (p=0.076), number of postoperative medications (p=0.263), success rate (p=0.900), reduction rate of ECD (p=0.410), or difference in visual acuity (p=0.174). The reduction rate of IOP was significantly high in the Trab group (p=0.047).Conclusions: Both surgeries significantly decreased IOP and were useful surgical methods for low-IOP glaucoma. Our results suggest that trabeculectomy can decrease IOP more than Ex-PRESS surgery but might have more complications.
Microbial Mediation of Carbon, Nitrogen and Sulfur Cycles During Solid Waste Decomposition
Authors: Song Liyan , Wang Yangqing , Zhang Rui , Yang Shu
Published: January 2022

Landfills is a unique “terrestrial ecosystem” and serves as a significant carbon sink. Microorganism convert biodegradable substances in municipal solid waste (MSW) to CH4, CO2 and microbial biomass, consisting of the carbon cycling in landfills. Meanwhile, microbial mediated N and S cycles affect carbon cycling. How microbial community structure and function respond to C, N, and S cycling during solid waste decomposition, however are not well characterized. Here we show the response of bacterial and archaeal community structure and functions to C, N, and S cycling during solid waste decomposition in a long-term (265 days) operation laboratory-scale bioreactor through 16S rRNA based pyrosequencing and metagenomics analysis. Bacterial and archaeal community composition varied during solid waste decomposition. Aerobic respiration was the main pathway for CO2 emission, while anaerobic C fixation was the main pathway in carbon fixation. Methanogenesis and denitrification increased during solid waste decomposition, suggesting increasing CH4 and N2O emission. In contract, fermentation decreased along solid waste decomposition. Interestingly, Clostridiales were abundant and showed potential for several pathways in C, N, and S cycling. Archaea were involved in many pathways of C and N cycles. There is a shift between bacteria and archaea involvement in N2 fixation along solid waste decomposition that bacteria Clostridiales and Bacteroidales were initial dominant and then Methanosarcinales increased and became dominant in methanogenic phase. These results provide extensive microbial mediation of C, N, and S cycling profiles during solid waste decomposition.
Impact of Ag2O on the mechanical and shielding features of ZnO- Er2O3-TeO2 glasses
Authors: Alzahrani Jamila S. , NIDZAM NAZIRUL NAZRIN SHAHROL , Halimah M. K. , Mahmoud K. , Sayyed M. I. , Hanfi M.Y. , Izzaty M. K. , Alrowaili Z.A. , Al-Buriahi M. S. , Boukhris Imed , Kebaili Imen
Published: January 2022

The investigation involves a comprehensive study on the mechanical and shielding features of the zinc erbium tellurite glasses as a function of doped Ag2O content. The mechanical features are estimated for the examined glasses by utilizing the Makishima-Makinzie model. The results showed the mechanical moduli of Young (E), bulk (B), Shear (K), and longitudinal (L) increased with the increment of the Ag2O substitution ratio. Besides, the radiation shielding properties were also studied and discussed. Among the shielding parameters, the linear attenuation coefficient (LAC), half-value layer (HVL), the lead equivalent and transmission rate (TR) were estimated. The linear attenuation coefficient results illustrated that the TZEAg glasses are better compared to the commercial marketing glasses, especially TZEAg5 glasses. Doping of Ag2O content in zinc erbium tellurite glass improves its ability to attenuate the gamma photons. Also, this study revealed the effectiveness of the examined glasses on the fast neutron, where the fast neutron mass removal cross-section ∑R (cm2/g) computed theoretically. The results offered the maximum value of ∑R = 0.019 cm2/g attained for TZEAg1 while the minimum value ∑R = 0.01884 cm2/g for TZEAg5 glass.
A Head-to-head Comparison of the EQ-5D-3L Index Scores Derived from the Two EQ-5D-3L Value Sets for China
Authors: Zhang Ruo-Yu , Wang Wei , Zhou Hui-Jun , Xuan Jianwei , Luo Nan , Wang Pei
Published: January 2022

Background: Two EQ-5D-3L (3L) value sets (developed in 2014 and 2018) co-exist in China. The study examined the level of agreement between index scores for all the 243 health states derived from them at both absolute and relative levels and compared the responsiveness of the two indices. Methods: Intraclass correlations coefficient (ICC) and Bland-Altman plot were adopted to assess the degree of agreement between the two indices at the absolute level. Health gains for 29,403 possible transitions between pairs of 3L health states were calculated to assess the agreement at the relative level. Their responsiveness for the transitions was assessed using Cohen effect size.Results：The mean (standard deviation, SD) value was 0.427 (0.206) and 0.649 (0.189) for the 3L2014 and 3L2018 index scores, respectively. Although the ICC value showed good agreement (i.e., 0.896), 88.9% (216/243) of the points were beyond the minimum important difference limit according to the Bland-Altman plot. The mean health gains for the 29,403 health transitions was 0.234 (3L2014 index score) and 0.216 (3L2018 index score). The two indices predicted consistent transitions in 23,720 (80.7%) of 29,403 pairs. For the consistent pairs, Cohen effective size value was 1.05 (3L2014 index score) or 1.06 (3L2018 index score); and the 3L2014 index score only yielded 0.007 more utility gains. However, the results based on the two measures varied substantially according to the direction and magnitude of health change. Conclusion：The 3L2014 and 3L2018 index scores are not interchangeable. The choice between them is likely to influence QALYs estimations.
High-dose Methotrexate and Rituximab Induction Regimen In Immunocompetent Patients With Primary CNS Lymphoma: A Retrospective Single-Center Study of Survival Predictors
Authors: DeAtkine Andrew Burton , Abdelrashid Moaaz , Tucker Zach , Markert James M. , Kim Jinsuh , Fiveash John B. , Oster Robert A. , Lobbous Mina , Nabors L. Burt
Published: January 2022

Purpose:Primary Central Nervous System Lymphoma (PCNSL) is an aggressive tumor that is confined to the CNS. Although the provision of high-dose methotrexate (HD-MTX) has remarkably improved outcomes in PCNSL patients, the optimal treatment regimens and standard MTX dose have been largely controversial. Herein, we sought to explore the impact of adjuvant Rituximab and different dosages of HD-MTX on survival outcomes of immunocompetent patients with PCNSL.Methods:In this study, we examined patients with PCNSL treated at a single NCI-designated comprehensive cancer center to evaluate their survival outcomes. We conducted a retrospective analysis of 51 immunocompetent patients with PCNSL who received their induction chemotherapy at the University of Alabama at Birmingham (UAB) between 2001 and 2019. Only adult patients with a confirmed diagnosis of PCNSL who had either HD-MTX alone or in combination with Rituximab were included. Patients’ demographics, clinical characteristics, and survival data were collected and analyzed.Results:There is no significant difference in survival among patients who received MTX alone versus MTX plus Rituximab. Furthermore, lower doses of MTX were associated with worse survival outcomes; however, this difference in survival was not significant when adjusted to age.Conclusion:Our experience challenges the role of Rituximab in PCNSL during induction therapy. Our study also highlights the shorter survival in elderly patients with PCNSL which can be related, to some extent, to the relatively lower doses of HD-MTX. There is an unmet need to establish a consensus on the most effective upfront regimen in PCNSL through prospective studies.
Peatland Degradation Reduces Microbial Richness and Alters Microbial Functions in an Australian Peatland
Authors: Birnbaum C , Wood Jennifer , Lilleskov Erik , Lamit Louis James , Shannon James , Brewer Matthew , Grover Samantha
Published: January 2022

Peatland ecosystems cover only 3 % of the world’s land area, however they store one-third of the global soil carbon (C). Peatlands play a central role in global C cycling as they contain more organic C than any other terrestrial ecosystem. Microbial communities are the main drivers of C decomposition in peatlands, yet we have limited knowledge of their structure and function. We investigated the vertical stratification of prokaryote and fungal communities from Wellington Plains peatland in the Australian Alps. Within the peatland complex, bog peat was sampled from the intact peatland and dried peat from the degraded peatland along a vertical soil depth gradient (i.e., acrotelm, mesotelm and catotelm). We analysed the prokaryote and fungal community structure, predicted functional profiles of prokaryotes using PICRUSt and assigned soil fungal guilds using FUNGuild. We found that the structure and the function of prokaryotes was vertically stratified in the intact bog. Carbon, manganese, nitrogen, lead and sodium best explained the prokaryote composition. Prokaryote richness was significantly higher in the intact bog acrotelm compared to degraded bog acrotelm. Fungal composition remained similar across the soil depth gradient, however there was a considerable increase in saprotroph abundance and decrease in endophyte abundance along the vertical soil depth gradient. The abundance of saprotrophs and plant pathogens was two-fold higher in the degraded bog acrotelm. Manganese, nitrogen, electrical conductivity and water table level (cm) best explained the fungal composition. Our results demonstrate that both fungal and prokaryote communities are shaped by soil abiotic factors and peatland degradation reduces microbial richness and alters microbial functions. Thus, current and future changes to the environmental conditions in these peatlands may lead to altered microbial community structure and associated functions which may have implications for broader ecosystem function changes in peatlands.
The emergency visits for back and neck pain during lockdowns
Authors: Ohana Nissim , Engel Itzhak , Baruch Yuval , Daniel Benharroch , Dimitri Sheinis
Published: January 2022

Purpose

To assess the rate of visits to the emergency department of our medical center concerning low back or neck pain as a factor of COVID-19 confinement.
Methods

The study period was a 30-week interval during the COVID-19 pandemic contrasted by a similar stretch in the year preceding the epidemic. Visits to the emergency department prompted by low back or neck pain were recorded prior to and during lockdowns of the pandemic. The significance of the confinements for the development of pain syndromes was evaluated.
Results

A total of 1530 patients with newly diagnosed back or neck pain were enrolled. Most patients visited our emergency department for low back pain, commonly those older than 60 years. No significant gender variance was disclosed, although most visits of females were for low back pain. Low back pain presentations were curbed following confinement, but the rate of stays for neck pain swelled by more than 10%. Despite back pain predominance, visits for neck pain persisted. Before COVID-19, the average weekly number of emergency department visits was 38.5. This was followed by sharp drops during the COVID-19 lockdown (mean difference=-22.2, 95% CI=-28.7, -15.7, p<0.001) (not significant).
Conclusions

COVID-19 lockdowns have a significant impact on emergency department presentations due to back and neck pain. A higher rate of presentation for back pain compared to neck pain is probably related to COVID-19, without being affected directly by SARS-CoV-2: confinement-induced immobility might instigate musculoskeletal sequelae, which may be attributed to stress or other psychosocial afflictions.
Functional Stratification of Cancer Drugs through Integrated Network Similarity
Authors: Tuncbag Nurcan , Beyge Seyma Unsal
Published: January 2022

Heterogeneity across tumors is the main obstacle in developing treatment strategies. Drug molecules not only perturb their immediate protein targets but also modulate multiple signaling pathways. In this study, we explored the networks modulated by several drug molecules across multiple cancer cell lines by integrating the drug targets with transcriptomic and phosphoproteomic data. As a result, we obtained 236 reconstructed networks covering five cell lines and 70 drugs. A rigorous topological and pathway analysis showed that chemically and functionally different drugs may modulate overlapping networks. Additionally, we revealed a set of tumor-specific hidden pathways with the help of drug network models that are not detectable from the initial data. The difference in the target selectivity of the drugs leads to disjoint networks despite sharing the exact mechanism of action, e.g., HDAC inhibitors. We also used the reconstructed network models to study potential drug combinations based on the topological separation, found literature evidence for a set of drug pairs. Overall, the network-level exploration of the drug perturbations may potentially help optimize treatment strategies and suggest new drug combinations.
An Accurate Leakage Localization Method for Water Supply Network Based on Deep Learning Network
Authors: Li Juan , Zheng Wenjun , Lu Changgang
Published: January 2022

In the water supply network, leakage of pipes will cause water loss and increase the risk of environmental pollution. For water supply systems, identifying the leak point can improve the efficiency of pipeline leak repair. Most existing leak location methods can only locate the leak point approximately to the node or pipe section of the pipe network, but cannot locate the specific location of the pipe section. This paper presents a framework for accurate location of water supply network leakage based on ResNet. The framework is to pinpoint leaks to specific locations along the pipeline. The leakage of two kinds of pipe networks is simulated. For a pipe network containing 40 pipes, the positioning accuracy of the pipe section is 0.94, and the MSE of the specific location of the leakage point is 0.000435. For the pipe network containing 117 pipes, the positioning accuracy of the pipe section is 0.91, and the MSE of the specific location of the leakage point is 0.0009177, and the leak location ability under different sensor arrangements is analyzed. Experiments verify the robustness and applicability of the framework.
Outstanding Discoveries of Mongolian Historians and Archaeologists: Excavations of the Sar’dag Monastery
Authors:   Institute for Mongolian, Buddhist and Tibetan Studies, Siberian Branch, Russian Academy of Sciences, Tsymzhit P. Vanchikova
Published: January 2022

Mongolia is rich in a unique cultural heritage presented by a variety of discovered artifacts that continue to amaze now. Among them, it is quite deservedly possible to include the findings discovered by a complex group of researchers on the ruins of the Sar’dag monastery, which was one of the earliest and largest Mongolian monastic complexes, the de factor center of the religious and political life of the Mongols. The review provides an overview of the works included in the collective monograph “The Sar’dag monastery of Undur-gegen Zanabazar: the Centre of artistic creativity”, published under the editorship of Sampildondovyn Chuluun, the Academician of the Mongolian Academy of Sciences. This work is the result of six years of archaeological excavations conducted by a large scientific team in 2013–2018. The results obtained made it possible to restore the structure of the monastery complex, opened new, previously unknown pages of the activity of Undur-gegen Zanabazar. The artifacts found indicate the existence of wide external relations of the Mongols of that period with foreign countries. Articles on the preservation, restoration and digital documentation of found artifacts are of great scientific interest and relevance. In general, the results of the conducted works provide a new rich source material for a more in-depth study of the history of Mongolia of the period under consideration.
On the Issue of Creating a Russian Agent Network in Shanghai at the Beginning of the 20th Century
Authors:   Transbaikal State University, Evgeny V. Drobotushenko
Published: January 2022

The history of the creation of the agent network of the Russian Empire has not found comprehensive coverage in scientific publications so far. The existing research referred to specific names or mention private facts. This predetermined the relevance of the work. The object of the study is the Russian agents in China in general and in Chinese Shanghai, in particular. The subject is the study of peculiarities of the first attempts in creating Russian agent network in the city. The aim of the work is to analyze the attempt to create a network of Russian illegal agents in Shanghai in 1906–1908. The lack of materials on the problem in scientific and popular scientific publications predetermined the use of previously unknown or little-known archival sources. This is the correspondence of the Minister of Foreign Affairs, the Russian Imperial envoy in Beijing and the Russian Consul in Shanghai stored in the funds of the State Archive of the Russian Federation (SARF). The main conclusion of the study was the remark about the lack of scientific elaboration, at the moment, the history of official, legal and illegal agents of the Russian Empire in Shanghai, China. Private findings suggest that, judging by the available data, creation of a serious network of agents in the city during the Russian Empire failed. The reasons for this, presumably, were several: the lack of qualified agents with knowledge of Chinese or, at least, English, who could work effectively; the lack of funds for the maintenance of agents, a small number of Russian citizens, the remoteness of Shanghai from the Russian-Chinese border, etc. A network of agents will be created in the city by the Soviet authorities by the middle of the third decade of the 20th century, and Soviet illegal agents began to work in the early 1920s. The History of Soviet agents in China and Shanghai, in particular, is studied quite well which cannot be said about the previous period. It is obvious that further serious work with archival sources is required to recreate as complete as possible the history of Russian legal and illegal agents in Shanghai in pre-Soviet times
Singer of the Trans-Baikal Cossacks: F. F. Tyutchev in the Russian-Japanese War
Authors:   Book and Magazine Publishing House “Granitsa”, Alexander L. Kalinichenko
Published: January 2022

Russian Army and Border guard Colonel Fyodor Fyodorovich Tyutchev (1860–1916), a well – known chronicler of the Russian army and the border guard, served in the Russo-Japanese War of 1904–1905.The purpose of the publication is a comprehensive description of the stay in the Russo-Japanese War of 1904– 1905. The work used sources that had not been previously introduced into scientific circulation, which allowed analyzing the formation of F. F. Tyutchev as a military professional, as well as concretizing the literary and aesthetic concept of the writer. Russian-Japanese War correspondent F. F. Tyutchev, being a correspondent of the newspaper Novoe Vremya, promptly transmitted “hot” information about the affairs of the Russian army to the editorial office. The writer collecting material for future literary works talked with the participants of the Japanese campaign, valuing the opportunity to have conversations not only with the lower ranks who were on the front line but also with the generals whose decisions the outcome of hostilities sometimes depended on. According to the works by Fyodor Fedorovich, we can judge not only the events that took place in the Far East but also analyze the writer’s civil and author’s position, investigate his philosophical beliefs on what is happening, clarify his thoughts, compare the assessments given to him from what he saw and experienced in the war. The presented article develops scientific ideas and traditions in the field of national historiography, generalizing and analyzing individual, previously unknown materials about the Russian-Japanese war and its participants. F. F. Tyutchev, being on the staff of the 1st Argun regiment not only participated in the fighting but also proved himself as a talented artist of the word, conveying the truth of the Japanese campaign in his writings, creating a portrait gallery of the personnel of the regiments of the Trans-Baikal Cossack army.
Weapon Sets of the Kushulevsky III Burial Ground of the Pyanobor Archaeological Culture
Authors:   Ufa Federal Center, Russian Academy of Sciences, Vsevolod I. Lyasovich
Published: January 2022

One of the important directions in the study of military affairs of the Pyanobor culture is the study of weapon sets. A set of weapons means armaments in a specific closed complex. Their study allows us to understand the degree of the population’s armament, its diversity, the demand for certain types of weapons. The problem of the research lies in the fact that such conclusions were made on the basis of an analysis of complexes with weapons from only one burial ground. It was for this reason that the decision was made to analyze the larger-scale necropolis of the Pyanobor culture, in which the number of those buried with items of weapons significantly exceeds those previously studied. This was the Kushulevsky III burial ground. The purpose of this article is to identify and analyze sets of weapons for male burials at the Kushulevsky III burial ground. It is also necessary to compare the data obtained on the weapon sets of the Kushulevsky III burial ground with the necropolises already studied in a similar way: the Okhlebininsky Kara-Abyz culture and the Yuldashevsky Pyanobor culture. It will be fundamentally important to identify the types of arrowheads from the burials of the Kushulevsky III burial ground.An explanatory model for reducing the number of horse bridle sets in military burials of the Pyanobor culture is also presented. In the specialized literature, these theoretical conclusions are described for the first time, which determines the novelty of this work. This work was made possible by the use of statistical calculations, the comparative historical method, as well as the methods of chronology and typology. The use of these techniques made it possible to establish the number of weapons items, their types, types of weapon sets, chronology, etc. The result of the work performed was a demonstration of the proximity of the weapon sets of the Pyanobor and Kara-Abyz cultures. In some cases, certain categories of weapons predominate, for example, bone arrowheads. In bladed weapons, the single-edged combat knife is the most used. In the same category of weapons, there is an electiveness and singularity of swords hitting the drunken population. The combination of a combat knife with a bow or spear forms a standardized complex of weapons of the Pyanobor culture.
Organization of Management of the Gold Mining Industry in Siberia in the Early 1920s
Authors:   Novosibirsk State Pedagogical University, Vitaliy G. Zelyak
Published: January 2022

The main purpose of the article is to analyze the evolution of organizational forms of management of the Siberian gold industry in 1920–1922. The relevance of the research is determined by the fact that significant gaps in historiography of the industrial development of Siberia are filled, the experience of managerial decisions on the organization of the work of the Siberian gold mining in the emergency conditions of the early 1920s is studied. The author used primarily historical-genetic, historical-comparative, concrete-historical methods. The methodological basis of the research is a region-oriented approach developed within the framework of the modernization theory. The study found that during the revolutionary events in Siberia, the gold mining industry in this region declined, so the central and Siberian authorities had to do a lot of work to restore this industry. In 1920, the Siberian Mining Department with a specialized sub-department Sibzoloto was organized to manage the mining industry and the gold mining industry as an integral part of it. Numerous problems made it difficult to manage the gold mining complex, but the activities of the Siberian Mining Department should be recognized as very useful. Regional departments of the gold mining and platinum industry were formed to organize gold mining operations on the ground. The work of all district departments was coordinated by the Siberian Mining Department, through which their interaction with the center was carried out. However, such large units as Lenzoloto often directly interacted with Moscow. At the end of 1921, the Siberian Mining Department was reduced and the management of the gold mining industry was seriously disrupted. At the same time, during this period, there was a significantly greater interest in the development of gold mining on the part of the central authorities than on the part of Sibrevkom and Sibpromburo, which in turn hindered the development of the industry. In general, a number of poorly thought-out management decisions, and above all, the liquidation of the unified management body of the Siberian mining industry, aggravated the unstable work of the industry
Formation and Development of Female Gymnasium Education in the City of Chita (1893–1921)
Authors:   State Archives of the TransBaikal Territory, Victoria A. Kondratenko
Published: January 2022

The article analyzes the role of women’s gymnasiums in the city of Chita in public education system of the Trans-Baikal Region of the late 19th – early 20th centuries, based on documents from the State Archives of the Trans-Baikal Territory and the Irkutsk Region. The author considers the main aspects of the activities of educational institutions: the problems of the creation and existence of female gymnasiums, the organization and content of the educational process, the material base, and also pays attention to the issue of training teachers for secondary educational institutions. The analysis of the level of knowledge of the topic, the content of archival funds is carried out. The research methodology is based on the application of the method of functional analysis, historical-genetic and historical-comparative methods. The source base of the study is presented by the reporting documentation of the gymnasiums, including design and estimate, for different years of their existence, correspondence of superiors with higher officials on the organization of the educational process and others. The article is illustrated with a large volume of photographic materials – photographs of the commanding persons, students and educational buildings of the indicated educational institutions. However, in spite of a sufficient number of archival documents, the researchers did not submit extensive work on the activities of women’s gymnasiums in the Trans-Baikal region. At the end of the article, the author provides an assessment of the activities of the Chita women’s gymnasiums. The study is timed to celebrate two anniversaries: the 115th anniversary of the opening of the Second Women’s Gymnasium (1906) and the 110th anniversary of the Private Women’s Gymnasium of O. M. Tsinbal-Miklashevskaya (1911).
DEMOKRASİYE GEÇİŞ SÜRECİNDE İSPANYA SOLU
Authors: SERÇE Uğur
Published: January 2022

Bu çalışmada, Francisco Franco’nun 1975 yılında ölümünün ardından demokrasiye geçiş sürecinde İspanya solunun takip ettiği politikalar incelenmektedir. İnceleme, ülkede solu temsil eden iki büyük parti olan İspanyol Sosyalist İşçi Partisi (PSOE) ve İspanya Komünist Partisi (PCE) tarafından izlenen politikalardan yola çıkılarak gerçekleştirilmektedir. İspanya’da, 1975 ile 1982 yılları arasında demokratik bir yönetim kurulurken, PSOE ve PCE’nin kritik konularda ne tarz bir tutum içerisinde oldukları ve demokratikleşme sürecine ne şekilde katkı sundukları, çalışmanın odak noktalarını teşkil etmektedir. Benimsemiş oldukları tutumların sözü edilen partiler üzerinde yaratmış olduğu etki de bu kapsamda değerlendirmeye tabi tutulmaktadır. Yapılan değerlendirmelerde, Nicos Poulantzas’ın, diktatörlük rejimlerinin yıkılmasına ilişkin olarak yapmış olduğu analizlerden yararlanılmaktadır. Belirtilenlere ilaveten ele alınan dönemde ülkenin içerisinde bulunduğu siyasi ve ekonomik koşullar da çalışma içerisinde önemli yer tutmaktadır.
ARTE E REALIDADE: A PANDEMIA EM VERSOS E IMAGENS
Authors: Battezzati Ligia Cristina
Published: January 2022

Este trabalho apresenta um contexto da pandemia de Covid-19 que se estabeleceu em todo o mundo a partir da disseminação do novo coronavírus, em 2020. Diante desta realidade, defendemos a Arte e a Cultura como possíveis estratégias de enfrentamento das consequências trazidas pela pandemia à saúde mental. Mais do que entretenimento, a Arte é uma maneira de entender e ressignificar o mundo. Com a imposição dos protocolos de segurança sanitária, do isolamento social e da suspensão de atividades presenciais, muitas ações artísticas e culturais ao redor do mundo precisaram se reinventar. O Caleidoscópio – as diversas expressões da Arte, projeto de extensão desenvolvido no Instituto Federal de Educação, Ciência e Tecnologia do Paraná (IFPR) Campus Curitiba, também se deparou com a necessidade de adaptar as suas atividades para o espaço virtual. Foi criado um perfil do projeto em uma rede social, o Instagram @caleidoscopio_ifpr. Uma das ações promovidas por um grupo de pessoas envolvidas no projeto, em parceria com a Biblioteca do IFPR Campus Curitiba, foi um concurso de poesias e de ilustrações de poesias, que tinha como tema: “Reflexões em tempos de isolamento ou o que se passa nos dias de pandemia”. O evento contou com uma expressiva participação popular por meio de likes nas publicações do Instagram, e envolveu as comunidades externa e interna do IFPR. A tradução da realidade em versos e imagens proporcionou aos envolvidos uma sensível reflexão acerca do momento que estamos vivendo.
Antibacterial Profile in vitro and in vivo of New 1,4-Naphthoquinones Tethered to 1,2,3-1H-Triazoles against the Planktonic Growth of Streptococcus mutans
Authors: Gomes Mônica , Correia Eduardo , Gomes Max , dos Santos Claudio , Barros Caroline , de Abreu Fernanda , Antunes Leonardo , Ferreira Vitor , Gonçalves Mariana , de Resende Gabriel , Gonzaga Daniel , Pinto Carla , Paixão Izabel , da Silva Fernando
Published: January 2022

The cariogenic processes are mainly caused by the bacterium Streptococcus mutans (S. mutans) and consist of the demineralization of the tooth that occurs when the acid production overcomes the natural repair or if a problem occurs in the last one. In this work, we performed the synthesis of twenty-one 1,4-naphthoquinones tethered to 1,2,3-1H-triazoles (8a-8k and 9a-9j), antibacterial evaluation against the S. mutans in vitro and the acute toxicity of the better ones in vivo. We observed strong inhibition results in the disc diffusion test ranging, the halos of inhibitions, from 18.66 (± 0.57) to 29 (± 2.64) mm, and good values in the minimum inhibitory concentration (5 to 50 μg), for the compounds 9e, 9h, 9i and 9j. Furthermore, they do not have a cytotoxic effect at the concentrations tested. Besides that, in the in vivo test, they show some slight alteration in the histopathological analyses and the biochemistry. Thus, we found four potential candidates to become instruments for the treatment of cavities.
Análise retrospectiva das causas de condenações de carcaças e vísceras de bovinos abatidos em abatedouros frigoríficos na Região Norte da Amazônia Oriental
Authors: Neto Manoel Soares Damasceno , Nunes Emília do Socorro Conceição de Lima , Silva Welligton Conceição da
Published: January 2022

Este trabalho buscou determinar as principais causas de condenação de carcaças e de órgãos diagnosticadas pelo serviço de inspeção oficial, nos frigoríficos sob inspeção federal que atendem o estado do Pará. A quantidade total de lesões encontradas em carcaças bovinas foi de 60.511, o que representou 0,78% do total de bovinos abatidos (7.706,638) durante o período estudado. A contusão foi a maior causa encontrada em carcaças bovinas com 21.270 achados (35,1%), seguida da contaminação com 17.865 ocorrências (29,5%). Os pulmões, os rins e o fígado foram as vísceras condenadas em maior quantidade abrangendo um quantitativo de 1.038.623, 468.540 e 231.318, respectivamente, sendo o enfisema pulmonar, o cisto urinário e a teleangiectasia hepática as principais causas de condenação. Nos demais órgãos inspecionados, a contaminação foi a primeira causa de descarte de cabeça, intestinos, coração, língua e cauda, culminando com elevados percentuais de 83,9%, 63,3%, 49,8%, 80,2% e 73,2%, respectivamente, evidenciando a necessidade de acentuar os treinamentos dos funcionários da indústria envolvidos no processo de abate e tecnologia da carne e a importância da realização das inspeções sanitárias pelo Médico Veterinário oficial nos matadouros frigoríficos para a preservação da saúde da população.
Fuel and energy enterprises as objects of risk-oriented sanitary-epidemiologic surveillance
Authors:   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya Str., Perm, 614045, Russian Federation, Andrishunas А.М. , Kleyn S.V. ,   Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, 82 Monastyrskaya Str., Perm, 614045, Russian Federation
Published: January 2022

The present research aims to provide analytical support for the risk-oriented model of sanitary-epidemiologic control over fuel and energy enterprises. The research task were to reveal the most common violations of sanitary-epidemiologic requirements by fuel and energy enterprises; to determine priority environmental indicators that should be included into a program of laboratory support for control and surveillance activities; to estimate actual impacts exerted by fuel and energy enterprises. We established that in 2020 there were totally more than 6 thousand economic entities that performed their activity in the sphere of “Electric energy, gas and steam supply; air conditioning”. Since fuel and energy enterprises tend to be located close to residential areas, violations in the sphere of ambient air protection (Clause 20) involve negative influence on a considerable number of people. In 2020 the greatest number of revealed violation regarding requirements to ambient air quality was registered for heat and power engineering enterprises in the Far East Federal District (FEFD), Siberian FD (SFD), Central FD (CFD), and Ural FD (UFD) and varied from 10.6 to 42.9 %. Average potential health risk (Rlav) per one economic entity amounted to 5.44∙10-4 for heat and power engineering. A share of economic entities dealing with this economic activity and assigned into extremely high and high (the 1st and 2nd accordingly) risk categories as per potential health risk amounts to 21.7 %. A scale of exposure (Mli) for economic entities operating in heat and power engineering can reach 930 thousand people. The greatest share of economic entities belonging to the 1st and 2nd risk categories as per potential health risk is registered in the SFD, Volga FD, CFD, UFD, and FEFD and amounts to 78.5 %. The greatest average potential health risk per one economic entity (Rlav) in the sphere of “Electric energy, gas and steam supply; air conditioning” was registered in the Siberian Federal District and amounted to 9.88∙10-4. The greatest numbers of economic entities operating in the sphere of “Electric energy, gas and steam supply; air conditioning” that belonged to the 1st and 2nd risk categories as per potential health risk are located in the Krasnoyarsk region (37.9 %), Kemerovo region (32.6 %), Tomsk and Omsk regions (29.7 % each).
Molecular Docking of Phytochemical Compounds of Momordica charantia
as Potential Inhibitors against SARS-CoV-2
Authors: Evary Yayu Mulsiani , Masyita Ayu , Kurnianto Arie Ariezandi , Asri Rangga Meidianto , Rifai Yusnita
Published: January 2022

Background:

Coronavirus disease 2019 (COVID-19) has been recently declared as a global
public health emergency, where the infection is caused by SARS-CoV-2. Nowadays, there is no specific
treatment to cure this infection. The main protease (Mpro) of SARS-CoV-2 and SARS spike glycoprotein-
human ACE2 complex have been recognized as suitable targets for treatment, including
COVID-19 vaccines.

Objective::

In our current study, we identified the potential of Momordica charantia as a prospective
alternative and a choice in dietary food during a pandemic.

Materials and Methods:

A total of 16 bioactive compounds of Momordica charantia were screened
for activity against 6LU7 and 6CS2 with AutoDockVina.

Results:

We found that momordicoside B showed the lowest binding energy compared to other compounds.
In addition, kuguaglycoside A and cucurbitadienol showed better profiles for drug-like properties
based on Lipinski's rule of five.

Conclusion:

Our result indicates that these molecules can be further explored as promising candidates
against SARS-CoV-2 or Momordica charantia can be used as one of the best food alternatives to be
consumed during the pandemic.
effect of HIV/AIDS education prevention using web-based she smart on knowledge, attitudes, and practice in adolescent girls
Authors: Muslimin Komala Dewi , Baso Yusring Sanusi , Hidayanty Healthy , Syarif Syafruddin , Aminuddin Aminuddin , Bahar Burhanuddin
Published: January 2022

From year to year the number of cases of people with HIV/AIDS has increased. This increase is also experienced in Indonesia, where adolescents infected with HIV/AIDS show a number that tends to rise. It is characterized by a teenager's ignorance about reproductive health and knowledge of his sexual state. So many teenagers are at risk for early marriage problems, pregnancy, sexually transmitted infections, and also HIV/AIDS. To look at the influence of HIV/AIDS education on the knowledge, attitudes, and Practice of Adolescent girls. Use Pre-Experiment with one group pre-test and post-test design. Sampling technique using purposive sampling and obtained the number of 47 students. The research was conducted in Senior High School 12 Makassar in September-October 2021. Data analysis using the McNemar Test. And statistical test results showed there was an influence on the use of HIV/AIDS education using web-based She Smart on knowledge where p-value = 0,000, attitude with a value of p-value = 0.000, and no significant difference in action with p-value = 0.500.  There is an influence on the use of web-based HIV/AIDS education using She Smart on knowledge and attitudes but no significant influence on actions before and after an intervention.
Soumission, le roman de la conversion Houellebecq, le réel et la fiction
Authors: Padovani Laurent
Published: January 2022

Houellebecq’s fiction isdiscussed, contested and critiqued, not only as a series of aesthetic objects but alsoin political, ideological or moral terms. This contribution is an invitation to thinkabout the centre of gravity inthe triangle of realism-fiction-authority in Submission, Michel Houellebecq’smost controversial novel. We advancethe hypothesis that Islam in Submissionhasa fictional function analogous to that of post-humanism in Atomised.That would be essentially a matter of surface, provocation to draw attention to an older deeper crisis. This crisis would be that of Western civilization, onethatFrance willnot escapefrom, characterizedby a process of generalized«untying», or even«disintegration» of « values»and the world that they formed.
Surveilans Retrospektif Penggunaan Antibiotik Pada Pasien Anak Dengan Luka Bakar
Authors:   Program Studi Farmasi, Fakultas Kedokteran Universitas Hang Tuah. Jalan Arief Rahman Hakim 150, Surabaya, Oki Nugraha Putra Okix , D. Saputro Iswinarno ,   Fakultas Kedokteran Universitas Airlangga – Departemen Bedah Plastik dan Rekonstruksi Estetika RSUD Dr. Soetomo, Jalan Prof Dr. Moestopo No.47,  Surabaya, D. Nurhalisa Hardiana ,   Program Studi Farmasi, Fakultas Kedokteran Universitas Hang Tuah. Jalan Arief Rahman Hakim 150, Surabaya, Yuliana Erma ,   Program Studi Farmasi, Fakultas Kedokteran Universitas Hang Tuah. Jalan Arief Rahman Hakim 150, Surabaya
Published: January 2022

Luka bakar merupakan salah satu bentuk trauma dengan tingkat risiko infeksi yang tinggi. Modalitas utama pada infeksi akibat luka bakar ialah pemberian antibiotik. Tujuan penelitian ini ialah untuk mengevaluasi penggunaan antibiotik pada pasien luka bakar anak secara kualitatif menggunakan metode Gyssens dan secara kuantitatif menggunakan metode ATC/defined daily dose (DDD). Pengambilan data dilakukan secara retrospektif melalui data rekam medik pasien luka bakar anak yang memenuhi kriteria inklusi yang dirawat di RSUD Dr. Soetomo pada tahun 2017-2019. Data diambil pada bulan November 2019 hingga Maret 2020. Didapatkan 18 pasien luka bakar anak yang memenuhi kategori inklusi. Antibiotik terbanyak yang digunakan pada penelitian ini yaitu ceftazidime sebesar 64,28%. Berdasarkan metode Gyssens didapatkan 27,77% antibiotik berada dalam kategori sudah sesuai dan sisanya termasuk dalam kategori kurang tepat dengan 84,6% termasuk kategori IIa (tidak tepat dosis) dan 15,4% termasuk kategori IVa (antibiotik lain yang lebih efektif). Berdasarkan metode ATC DDD, didapatkan nilai total DDD /100 patients-days sebesar 88,92 DDD/100patient-days dengan ceftazidime merupakan antibiotik dengan nilai terbesar yaitu 23,03 DDD/100 patient-days. Jenis antibiotik yang termasuk dalam DU 90% adalah ceftazidime (23,03), ampicillin-sulbactam (15,45), ceftriaxon (13,65), amikacin (11,91), gentamicin (9,67) dan meropenem (8,51). Kesimpulannya ialah secara kualitatif penggunaan antibiotik pada pasien luka bakar anak masih kurang sesuai dan secara kuantitatif penggunaan antibiotik melebihi standar WHO. Diperlukan perbaikan dalam rangka meningkatkan rasionalitas penggunaan antibiotik pada pasien luka bakar anak. Kata Kunci: Antibiotik, Luka Bakar, Anak, Gyssens, Defined Daily Dose