bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on Sleep APP Design Based on Visual Communication Analysis
Authors: Lan Xinwei
Published: January 2023

This research focused on the current demand for sleep products, analyzed the demand for healthy sleep products in today's society and recognized the importance of further visual communication for users of sleep products. This research also analyzed the function and structure of sleep hardware and software products, quantitatively analyzing their TGI index and penetration rate. The relationship between them and the visual communication of information was explored. The current situation of the visual communication part of the sleep APP products was analyzed. The design strategy of highlighting the visual communication focus, fitting the usage scenario and enhancing the branding of the product was proposed. This research provided a future direction for the design of health software and hardware products.
Research on the Impact of Corporate Social Responsibility on Corporate Value in Different Industries — Based on the Analysis of the Mediation Effect, the Regulation Effect and the GMM Model of Dynamic Panel System
Authors: Jia Yiding , Tian Yinghua
Published: January 2023

This paper focuses on listed companies in three sub-sectors of real estate, health care and information technology services, on the basis of studying the direct relationship between corporate social responsibility and its value, introduces the tax burden as an intermediary variable, studies the difference between the relationship established by the intermediary role of the two through the intermediary role of the tax burden compared to the direct relationship, and explores the degree of equity concentration, institutional investor shareholding degree in the moderating role between corporate social responsibility and value, respectively. The dynamic panel system GMM model is used to explore the impact of the first phase of enterprise value lag on its same period. Empirical analysis shows that in the sample of listed companies selected from the three industries, corporate social responsibility has a positive impact on corporate value, and the tax burden plays a certain intermediary role in it, the equity concentration of enterprises in different industries and the shareholding of institutional investors play a slightly different role in regulating corporate social responsibility and corporate value, and only the enterprise value of the healthcare industry lagging by one period has a significant impact on the current period.
ДОБІР IN VITRO МІЖВИДОВИХ ГІБРИДІВ F1 ПОМІДОРА, ПРИДАТНИХ ДЛЯ ВИКОРИСТАННЯ В ЯКОСТІ ПІДЩЕП
Authors: Ivchenko T. V. , Miroshnichenko T. M. , Bashtan N. O. , Mozgovska А. V. , Krutko R. V. , Shabetya O. M.
Published: January 2023

Мета – дослідити вплив селективних середовищ в культурі in vitro на життєздатність і показники росту і розвитку рослин-регенератів міжвидових гібридів помідора F1 і виділити перспективні генотипи для використання у якості підщеп. Методи. Загальнонаукові, вимірювальні, лабораторні, статистичні. Результати. Визначено вплив додавання у поживні середовища у якості селективних факторів 50% ФКР Alternaria solani (некротрофний патоген), 10г/л NaCl (засолення) та 0,1 г/л гідроксипроліну (посуха), а також підвищеного у 1,5 раза вмісту основних поживних речовин за прописом MS (середовище ІІ) на життєздатність та розвиток вегетативної маси і кореневої системи пробіркових рослин 8 міжвидових гібридів помідора F1. ФКР A. solani, NaCl та гідроксипролін спричиняли істотне зниження життєздатності рослин-регенерантів досліджених зразків та пригнічення їх росту і розвитку. Найбільш виражену селективну дію чинив гідроксипролін. Середовище ІІ істотно не впливало на досліджувані параметри рослин, тому не може бути використане для оцінки і добору зразків в культурі in vitro. Висновки. Використаний підхід дозволяє оцінювати і добирати серед міжвидових гібридів F1 в культурі in vitro стійкі до комплексу біо- та абіотичних факторів, сильнорослі підщепи помідора з розвиненою кореневою системою. За комплексом ознак в умовах ізольованої культури виділено гібриди F1 БК-88 і БК-91 – Т-5 / S. habrochaites, БК-96 – К-7311 / S. habrochaites і БК-156 –S. pimpinellifolium / S. lycopersicum var. cerasiforme, які є перспективними для використання у якості підщеп помідора.
ВПЛИВ РІЗНИХ СИСТЕМ УДОБРЕННЯ НА НАСІННЄВУ ПРОДУКТИВНІСТЬ ПОМІДОРУ
Authors: Kuts O. V. , Mykhailyn V. I. , Paramonova T. V. , Rozhkov A. O. , Onyshchenko O. I. , Semenenko I. I. , Hapon T. M. , Zhernova O. S.
Published: January 2023

Мета досліджень – визначити вплив різних систем удобрення на ріст та розвиток, насіннєву продуктивність рослин помідору за його вирощування на чорноземних ґрунтах зрошуваної овочекормової сівозміни Лісостепу України. Методи: польовий, лабораторний, статистичний аналіз. Отримані результати: Використання мінеральних добрив (врозкид, локально, по післядії органічних добрив) забезпечує суттєве збільшення висоти рослини (на 10,1–19,0 %), кількості китиць (на 1,71–3,23 шт./ рослину), маси рослини (на 61,2–109,1 %), а також зростання вмісту в листках хлорофілів А та В (до рівня 12,89–14,55 мг/кг), знижує активність пероксидази (58,4–71,8 ммоль/г за сек) і зумовлює підвищення урожайності насіння на 86,8–123,6 кг/га. Сидеральні системи удобрення (як в комплексі з післядією органічних добрив, так і з використанням мікробних препаратів) мають набагато менший вплив на ростові процеси рослин помідору, при цьому урожайність насіння зростає на 55 кг/га або 63,0 %. Найбільш високий рівень насіннєвої продуктивності помідору зазначено за використання мінеральних систем удобрення (врозкид N120P120K90 або N260P180K130 + позакореневі підживлення «Нутрівант плюс універсальний»), які забезпечують приріст урожайності насіння 86,8–123,6 кг/га та за органо-мінеральної системи удобрення (післядія 86 т/га гною + локально N60P60K45) з приростом урожайності насіння 120,7 кг/га (100–142 % відносно до контролю. Незалежно від систем удобрення, якість насіння помідору, за показниками схожості і маси 1000 насінин, відповідає вимогам ДСТУ 7160:2020. Висновки: Оптимальною системою удобрення помідору в овоче-кормовій зрошуваній сівозміні за сукупністю позитивного впливу на урожайність насіння та економію добрив є використання органо-мінеральної системи удобрення: N60P60K45 локально навесні по післядії 14 т/га гною сівозмінної площі, що забезпечує зростання урожайності насіння помідору на 120 кг/га або на 139%.
ІННОВАЦІЙНІ ЗОНАЛЬНО АДАПТОВАНІ РІШЕННЯ В ОВОЧІВНИЦТВІ
Authors: Rud V. P. , Ilinova Ye. M. , Mohylna O. M. , Terokhina L. A. , Dukhin E. O.
Published: January 2023

Актуальність. Питання детального аналізу можливих проблем і перспектив адаптації новітніх зональних техніко технологічних рішень щодо виробництва овочевої продукції в сучасних умовах є достатньо актуальними для функціонування аграрної сфери. Мета – проаналізувати стан галузі, здійснити прогноз розвитку овочівництва на перспективу та навести аналіз результатів досліджень впровадження інноваційних рішень в овочівництві. Матеріали і методи. Методологічною базою дослідження стали наукові праці з проблем формування та функціонування овочевого ринку. Використовувалися методи: групування, монографічний, систематизування. Результати досліджень. У статті здійснено аналіз сучасного стану виробництва овочів в Україні, встановлено основні проблеми його розвитку в сучасних умовах. На підставі досліджень проаналізовано стан галузі, здійснено прогноз розвитку овочівництва України та наведено результати досліджень з розробки та удосконалення зонально адаптованих технологій вирощування овоче-баштанної продукції. Встановлено доцільність використання запропонованих інновацій, визначено їх привабливість та ефективність для конкретних умов виробництва з метою підвищення науково-технічного прогресу в АПК. Доведено необхідність пошуку базових господарств у різних ґрунтово-кліматичних зонах України для здійснення апробації, виробничої перевірки та трансферу інноваційних розробок, з комплексним науковим забезпеченням. Встановлено, що впровадження зонально адаптованих рішень в овочівництві дозволить вирішити питання економічної самостійності окремих регіонів, продовольчої безпеки громад, підвищити рівень координації системи дій органів управління, суб’єктів господарювання, науковців та інвесторів на з асадах сталого розвитку в умовах військової агресії, або післявоєнного відновлення країни. Висновки. Ефективний розвиток галузі овочівництва необхідно спрямувати по шляху: впровадження інтенсивних, ресурсозберігаючих технологій виробництва овочевої продукції; оптимізації структури посівних площ основних сільськогосподарських культур на основі науково-обґрунтованих рекомендацій з урахуванням природно-економічних зон; раціонального використання зрошуваних земель; впровадження сучасних сортів, гібридів овочевих культур; науково-методичного забезпечення сільськогосподарського виробництва, поширення інформаційно-комунікаційних технологій.
INCOLOY 800HT IRON-BASED SUPERALLOY – PRELIMINARY CHARACTERISATION
Authors: PURZYŃSKA Hanna , GOLAŃSKI Grzegorz
Published: January 2023

The article presents and characterises Incoloy 800HT iron-based superalloy in terms of: chemical composition, heat treatment, microstructure and properties, in its delivery condition. This material is commonly used in process lines in the petrochemical industry, e.g. into components called ‘pigtails’.
DECARBONISATION PATHWAYS OF THE STEEL INDUSTRY
Authors: RÓŻAŃSKI Piotr , BORECKI Mariusz , NIESLER Marian , STECKO Janusz , SZULC Wojciech , ZDONEK Bogdan
Published: January 2023

The article was prepared on the basis of reports from the Green Steel for Europe (GREENSTEEL) project funded by the European Union as part of the implementation of the climate and energy goals for 2030 and the long-term strategy for a climate neutral Europe by 2050. A consortium of implementers composed of ten partners from EU countries, including Łukasiewicz – Institute for Ferrous Metallurgy in Gliwice, has identified promising technologies for the decarbonisation of the steel industry, defined technological pathways constituting process chains composed of these technologies, as well as scenarios of the decarbonisation process until 2030 and until 2050. The end result of the project is a set of insights and recommendations for effective clean steel manufacturing solutions suitable for the EU to achieve the EU’s climate and energy goals.
O caminhar educacional: Reflexões sobre homeschooling, anticientificismo e a educação brasileira
Authors: Santos Fábio Júnio Barbosa
Published: January 2023

O modelo educacional estabelecido no Brasil, em linhas gerais, incentivou a escolarização e padronização do ensino em detrimento da formação individual e autodidata. A forma como o modelo educacional brasileiro se estruturou ao longo do tempo, inviabilizou que famílias brasileiras pudessem optar pelo ensino domiciliar, tal empecilho legal tem gerado cada vez mais, um maior desconforto por parte de famílias que impedidas de ensinar a sua maneira, tendem a recorrer à justiça como alternativa de viabilização desse desejo. Com o passar do tempo, o aumento de ocorrências e relevância da pauta, estudos, pesquisas e até projetos de lei têm surgido com o propósito de debater e propor soluções para essa demanda que é uma realidade viável em diversos outros países. O presente trabalho tem por objetivo contribuir para o debate e reflexão sobre a Educação Domiciliar no Brasil, com base em uma metodologia bibliográfica, pautada em diferentes estudos e pesquisas, o presente texto, tem por escopo problematizar a forma como essa pauta tem sido discutida e proposta no cenário nacional, evidenciando visões antagônicas nesse processo e aprofundando a medida em que traz considerações a aspectos como o anticientificismo, a polarização política e algumas problemáticas pedagógicas derivadas desse debate. Conclui-se que assim como outras discussões, a possibilidade de um ensino domiciliar legalmente amparado no Brasil tem tomado um tom ideológico e polarizado, são percebidas sob perspectiva pedagógica a socialização e a negligência intelectual como dois dos aspectos mais preocupantes, além disso, são propostas reflexões e apontamentos acerca de exemplos como o modelo português de ensino domiciliar e o pensamento de um homeschooling brasileiro voltado meramente as elites.
User Task Scenarios for Map-Based Decision Support in Community Health Planning
Authors: Kelsey Brian , Rinner Claus
Published: January 2023

Health outcomes are affected by the socio-demographic and physical-environmental characteristics of the places where people live. Therefore, epidemiologists have been interested in the use of maps to explore spatial patterns of disease for a long time. Geographic Information Systems (GIS) are not only useful when visualizing complex spatial datasets but also when mapping the results of analytical processes. One such process is multi-criteria evaluation (MCE), which can be used to generate composite measures of public health based on individual, medical and non-medical factors.

The objective of this study was to determine if geovisual MCE can be an effective tool in community health planning. We provided highly interactive thematic maps coupled with MCE tools to planners at a community health centre and evaluated their use for community health planning and decision-making. User task scenarios were designed in a way to compare the usefulness of different representation methods for a number of tasks.

The pilot user test with two expert participants included interviews, questionnaires, and user task scenarios with think-aloud audio and screen video recording. We assessed the easiness of completing the tasks using completion rates and times and could identify a number of specific usability issues with the tool at hand.
Intergenerational Transmission of Abilities and Self Selection of Mexican Immigrants
Authors: Caponi Vincenzo
Published: January 2023

Building on Borjas (1993) I develop an intergenerational model of self-selection of migration and education that allows for a more complex selection mechanism. In particular, it allows for the possibility that immigrants are selected differently depending on the schooling level they choose. As in Mayer (2005) I assume that agents are endowed with two abilities and use the intergenerational structure of the model to infer potential earnings of a person for different levels of education and in different countries. This makes it possible to quantify the ability or self selection bias of estimates of the return to education and migration. The model is estimated using data on Mexicans in the US from the CPS and on Mexicans residents in Mexico from the Mexican census. The findings are that there is a significant loss of human capital faced by immigrants that is not transmitted to their children. While immigrants are observed to earn less because they find it difficult to adapt their skills to the host country, their children earn more because they can inherit all the abilities of their parents, including that part that could not be used for producing earnings. Moreover, Mayer (2005) proves that the positive correlation between the two abilities creates a positive correlation between parentsÕ earnings and the probability that children attend college. In this paper, I find that this result is reinforced for migrants when they care about their children. In the case of immigrants, parents with larger amounts of intellectual ability tend to migrate more and tend to choose to remain high school educated. However, they migrate with the expectation of their children becoming college educated. Therefore, measures that rely on the earnings performance and educational attainment of immigrants underestimate the amount of human capital they bring into the host country.
Learning from Tradition for Future: Green Building in Kano State, Nigeria
Authors: Yahuza Mukhtar Sabiu , Gurdalli Huriye
Published: January 2023

Green building can be considered as a building design through a method that is environmentally friendly in both construction, usage and energy consumption. Culture is yet to be included into the sustainable development pillars making it the fourth pillar of sustainability after social, economic and environmental aspects. Traditional Architecture can be regarded as beliefs, customs, or ways of life (culture) in building construction that have existed for a long period and involve the art of designing, planning, and traditional building style. These traditional buildings were copied and used in contemporary buildings in Kano state, Nigeria. Therefore, most of the contemporary building design and structure has their roots in a traditional building. Nigeria’s traditional buildings across the country were affected by climate and landform all over the geographical zones, which were recognised to demonstrate a detailed solution to the building’s culture, socio-economic, local technology and climatic condition of the environment. This study compares the past and the current building style based on the façade or floor-plan pictures, and green or sustainable building using relevant kinds of literature of Hausa traditional building around Kano state. It is concluded that Hausa traditional architecture should not be forgotten, rather it should be encouraged and improved based on green sustainable features, traditions and enhance the durability of the building materials. It is recommended that culture should be include into the pillars of sustainability so as to make sustainability complete especially in the field of building construction. Lastly, further research is recommended in order to explore ways of improving the quality of the local building materials and the methods used during the construction process.
Security and confidentiality of information under the application of cloud accounting compared to traditional accounting
Authors: Wali Kaka , Karim Darwish Bnar , Jabbar Abdulfattah Shadan
Published: January 2023

Due to the continuous development and transition from manual to electronic accounting methods, users are now finding that accounting is simpler and more convenient. The recent shift in accounting to a faster technology has greatly improved its ability to serve users.

The research aims at a number of objectives, including getting to know cloud accounting and software-based accounting, comparing the services of the top ten cloud accounting service providers around the world in terms of security and confidentiality to understand how they differ from traditional accounting, and understanding the current impact of cloud accounting using insights from accounting experts. Primary data were collected from accounting experts from various academics and professionals. A questionnaire form has been prepared for this purpose.

Secondary data were collected from annual reports, books, international journals, the Internet, and other sources. The information collected was helpful in understanding the concepts and their effectiveness.

According to the results, cloud accounting is a much-preferred option over traditional accounting for any organization looking to compete due to its many benefits, including accessibility, affordability, high security, and ease of use.

Further study is needed, recent advances in accounting not only help small and medium-sized businesses (SMEs) improve their efficiency but also provide significant cost savings. In such circumstances, it is necessary to ascertain whether companies and financial institutions such as banks that promote these trends in their operations bring clear benefits, as well as how this may affect the business future of newly established companies and institutions. This paper provides insight into cloud accounting in small and medium-sized businesses from a managerial accounting perspective.

 

Paper type: Research paper
Formaldehyde Adsorption and Sensing: A Density Functional Theory Study on Pd4 Nanocluster Decorated CNT Structure
Authors: Yuksel Numan , Kose Ahmet , Ferdi Fellah Mehmet
Published: January 2023

The sensing of formaldehyde, one of the volatile organic compounds used in chemical processes, is very important. In this study, the adsorption and sensing of formaldehyde molecule on Pd4 nanocluster decorated carbon nanotube (Pd4-CNT) was investigated by using DFT method. The WB97XD hybrid method was used in DFT calculations. The adsorption energy value was calculated as −8.1 kJ/mol. This low adsorption energy confirms the very short recovery time and the predominance of weak interactions. There was a decrease of approximately 20% in the HOMO-LUMO gap after the interaction. This result shows that the Pd4-CNT can be used as a sensor at room temperature.
Numerical and Experimental Study of the Use of Mineral Pumice in the Core of the Sandwich Panel to Absorb the Shock Wave
Authors: Kaffash Mirzarahimi Mahmoud , Khodarahmi Hossein , Ziashamami Mojtaba , Hosseini Rouhollah
Published: January 2023

Reducing the effects of unwanted shocks and waves is a very common problem in engineering. Some materials, due to their inherent properties, can be used as energy absorbers, such as foams, porous materials, and granular materials. porous granular materials that were considered in this study due to their low density and energy absorption capacity. But to use the granular material as the core of the sandwich panel, you have to think of a way to hold the granules together. In this article, using molding with resin, aluminum and polyurethane foam, an attempt has been made to make cores for sandwich panels from mineral pumice. the use of foam showed better performance than the other two materials. These adsorbents have the property of substrate flexibility and impact absorption and low density of porous materials at the same time. The properties of the core were obtained using a pressure test and used in software. Explosion experiments are free and Abaqus software is used in the simulation. The results show that the panel with a thicker back cover has a better performance in absorbing explosion energy. Increasing the thickness of the core has also increased energy absorption.
Örnekleme dağılımlarının tarihsel gelişimi: Ki-kare, t ve F dağılımları
Authors: SERİN Hakan , TAŞDELEN Seyit Mehmet , SEYHAN Davut , ÇAĞLAYAN Tamer , TEKİN Mehmet Emin
Published: January 2023

Örnekleme dağılımlarının temelini oluşturan Ki-kare, t ve F dağılımlarını sırasıyla Karl Pearson, William Sealy Gosset ve Ronald Aylmer Fisher istatistik bilimine kazandırmıştır. Karl Pearson, normal dağılım göstermeyen veriler için o dönemde yaptığı çalışmalar sonucu Ki-kare dağılımını elde etmiştir. Sonraki yıllarda Fisher, Ki-kare dağılımı üzerine yaptığı çalışmalar ile serbestlik derecesinde bir düzeltme yapmıştır. Bu durum Karl Pearson tarafından hoş karşılanmamış ancak çevresindeki bilim insanlarının etkisiyle bu modifikasyonu kabul etmek zorunda kalmıştır. Ayrıca, Fisher z dağılımının normalliği ile ilgili çalışmalar yapmış, bu konuda makale yazmış ve “Biometrika” dergisine göndermiştir. Ancak dönemin ünlü istatistik dergisi olan “Biometrika”ya başkanlık yapan Karl Pearson Fisher ile arasındaki rekabetten dolayı makalesini geri çevirmiştir. William Sealy Gosset o dönemde ünlü bir bira fabrikasında istatistikçi olarak çalışırken en iyi kalite ve verime sahip arpaları tespit etmek için yaptığı çalışmalar sonucu t dağılımını keşfetmiştir. Gosset’e mektup yazan Fisher, t dağılımında standart sapma hesaplamasında bir düzeltme tavsiye etmiştir. Bununla birlikte, Fisher makalelerinde t dağılımına değinerek t dağılımının bilim dünyasına tanıtımına katkıda bulunmuştur. Ronald Aylmer Fisher Rothamsted’ta mahsul çalışmaları yaparken mevcut yöntemlerin yetersizliği ile karşılaşmış ve t dağılımından yola çıkarak yaptığı çalışmalar sonucu F dağılımını keşfetmiştir. F dağılımının keşfi ile birlikte ileri düzey veri analizinde yeni bir dönem başlamıştır.
Penyusunan Peta Wilayah Berdasarkan Citra Sentinel-2B Dan Pemodelan Luas DAS Pada Jaringan Sungai Desa Antutan Kabupaten Bulungan Provinsi Kalimantan Utara
Authors: Utomo Edy , Bakri Muhammad Djaya , Widiyanti Aneza Ferdani
Published: January 2023

Desa Antutan merupakan bagian wilayah Kecamatan Tanjung Palas, Kabupaten Tana Tidung, Provinsi Kalimantan Utara. Des aini memiliki luas 10.060,62 Hektar. Berdasarkan koordinasi yang dilakukan dengan Kepala Desa Antutan, ditemukan bahwa perangkat desa belum memiliki peta wilayah desa yang bersifat autentik dan informatif untuk menunjang proses pengembangan desa selanjutnya. Oleh sebab itu, Laboratorium Pemetaan dan Geografis Teknik Sipil Universitas Borneo Tarakan melakukan kegiatan pengabdian masyarakat di desa tersebut. Selain melakukan penyusunan peta wilayah desa, tim juga menganlisis luas DAS dari beberapa sungai di wilayah desa tersebut, berdasarkan pemodelan Sistem Informasi Geografis memanfaatkan citra satelit Sentinel-2B dan data DEM Nasional. Berdasarkan kegiatan yang telah dilakukan, didapatkan hasil peta wilayah Desa Antutan yang autentik, representatif, dan informatif. Selain itu, pemodelan luas DAS menemukan hasil bahwa luas DAS dari sungai yang tersebar di wilayah Desa Antutan adalah sebesar 13.814,64 Hektar atau sekitar 86,02% dari luas wilayah Desa Antutan.
Optimalisasi Pemanfaatan Media Online Phet Simulation Untuk Upaya Peningkatkan Pemahaman Konsep Fisika di SMA N 2 Harau
Authors: Fardela Ramacos , Mardiansyah Dedi , Yusfi Meqorry , Namigo Elistia Liza , Afdal  , Vonnisa Mutya , Muldarisnur  , Harmadi  , Thaufiq Imam , Pohan Ahmad Fauzi , Astuti  , Muttaqin Afdhal , Fitriyani Dian , Pujiastuti Dwi , Handani Sri , Puryanti Dwi , Sutantyo Trengginas Eka Putra , Zulfi  , Irka Feriska Handayani , Mahyudin Alimin , Firmawati Nini , Milvita Dian , Oktamuliani Sri , Usna Sri Rahayu Alfitri , Adrial Rico
Published: January 2023

Fisika menganut metodologi ilmiah (sains) yang memuat tiga kegiatan terpadu dan membentuk daur (cycles) empirico-logico-verification yang pertama kali dirintis oleh I. Newton  yaitu (1) pengamatan gejala-gejala alam (kegiatan empiris melalui fisika eksperimen), (2) Penalaran untuk menjelaskan hasil pengamatan tersebut dan ekstensinya sehingga mampu menghasilkan ramalan mengenai gejala baru (kegiatan berlogika melalui fisika teori) dan (3) pengujian mengenai kesesuaian ramalan tersebut dengan realitas alam (kegiatan verifikasi melalui fisika eksperimen). Keberadaan laboratorium di sekolah-sekolah menjadi kunci keberhasilan dalam memperkenalkan tiga kegiatan terpadu tersebut. Sekolah Menengah Atas Negeri (SMAN) 2 Harau, Kabupaten Lima Puluh Kota merupakan sekolah di bawah naungan Provinsi Sumatera Barat dengan jarak sekitar 138 km dari Jurusan Fisika FMIPA Universitas Andalas tepatnya berada di Kecamatan Harau. Dari informasi yang diperoleh masih terbatasnya sarana dan prasarana seperti jumlah peralatan praktikum. Berdasarkan hal tersebut, tim pengabdian Jurusan Fisika FMIPA Universitas Andalas akan melaksanakan rangkaian kegiatan pengabdian masyarakat di SMA N 2 Harau dengan pemanfaatan media online salah satunya Phet- Simulation. Hasil pengabdian menunjukkan 90 % siswa mengatakan setuju dan sangat setuju bahwa kegiatan seperti ini memberikan manfaat bagi pemahaman materi di bidang Fisika. Kegiatan seperti ini perlu dilakukan lebih banyak oleh Tim Pengabdian sehingga masyarakat merasakan keberadaan perguuruan tinggi yang ada didaerahnya.

Kata kunci: PhET Colarado; Simulasi Fisika; dan Pengabdian Masyarakat
Analisa Sifat Mekanik pada Bahan Anti Peluru dari Adisi Berpenguat Serat Panjang Tandan Kosong Kelapa Sawit (TKKS)
Authors: Riza Okta , Nikmatin Siti , Hardhienata Hendradi , Syamani Firda Aulya
Published: January 2023

Kelapa sawit merupakan salah satu hasil perkebunan di Indonesia yang perkembangannya meningkat setiap tahun. TKKS merupakan limbah dari pabrik sawit yang pemanfaatannya belum optimal sehingga akan menjadi limbah padat. Penggunaan serat TKKS pada biokomposit adalah upaya reduksi dan pemanfaatan limbah TKKS yang melimpah. Tujuan dari penelitian ini adalah untuk mendapatkan biokomposit dengan adisi serat panjang TKKS ter-modifikasi untuk aplikasi bahan anti peluru dan mengetahui sifat mekanisnya. Sifat mekanik pada biokomposit yang diperoleh pada penelitian ini memiliki sifat mekanik yang baik untuk aplikasi bahan anti peluru, dimana biokomposit tersebut lentur dan mampu meredam gaya dan energi yang diberikan oleh peluru. Sampel terbaik berada pada biokomposit yang mengandung konsentrasi serat sebesar 18% dengan polimer epoxy
ANALISIS VERTICAL WIND SHEAR PADA PERTUMBUHAN AWAN CUMULONIMBUS DI WILAYAH KABUPATEN TANGERANG
Authors: Kholiviana Prisma Ayu , Ruhiat Yayat , Saefullah Asep
Published: January 2023

Awan cumulonimbus merupakan jenis awan berbahaya yang dapat menimbulkan cuaca ekstrim seperti hujan deras, kilat dan guruh. Jenis angin yang dapat mempengaruhi adanya awan cumulonimbus adalah Vertical wind shear, dengan adanya angin ini dapat menentukan jenis badai yang terjadi. Apakah termasuk kedalam badai dengan intensitas yang hebat atau tidak. Karena semakin besar Vertical wind shear akan semakin besar juga intensitas badai yang terjadi akibat adanya awan cumulonimbus. Untuk mengetahui keterkaitan Vertical wind shear pada pertumbuhan awan cumulonimbus maka diadakannya penelitian ini  menggunakan metode data cuaca permukaan dan menggunakan metode data cuaca permukaan ini kemudian diolah menggunakan Minitab dan Wind Rose. Setelah di analisis dan diolah menggunakan beberapa software dan perhitungan menggunakan dry adiabatic lapse rate dapat ditemukan terjadinya Awan cumulonimbus yang disertai intensitas curah hujan klasifikasi sedang terdapat pada tanggal 24 Februari 2020 dengan arah angin terbanyak dari sebelah barat yang secara topografi wilayah Kabupaten Tangerang berbatasan langsung dengan Kabupaten Serang dan Lebak, Banten. Hasil pengujian menggunakan software minitab dan juga windrose yang memanfaatkan data cuaca permukaan di Stasiun Meteorologi Budiarto Curug, terbentuknya awan cumulonimbus hingga terjadi hujan memiliki variasi arah angin yang berubah-ubah dari sudut 45? sampai dengan 124? menandakan adanya arah angin yang berubah-ubah dan menimbulkan terjadinya awan cumulonimbus. Suhu yang terukur pada bola kering atau disebut dengan suhu saat ini menunjukkan nilai 21,9? C sampai dengan 30,8? C mengalami penurunan suhu akibat terjadi hujan. Hujan yang terjadi akibat adanya awan cumulonimbus berlangsung selama 2 jam, dengan intensitas curah hujan sebesar 118,6 mm dan dikategorikan sebagai hujan sedang.
Evaluation of Embroidery Defects and Solution Proposals in Clothing Sector
Authors: KUCUK Mehmet , Birol Şafak
Published: January 2023

Nowadays, it has become more important to follow the latest developments concerning the clothing sector as staying up to date is likely to help us eliminate unnecessary expenditures and increase productivity. In order for companies to continue and expand their activities in ever-changing market conditions compared to their competitors, they need to make their own enterprises compatible with this emerging technology as much as possible by following the developing technology. In this study, the embroidery department of an exporting company was examined. More specifically, the embroidered products were carefully checked and faulty pieces were separated and classified according to the types of defects. The most critical defects were determined by means of Pareto analysis according to defect types and frequencies and an auxiliary apparatus was placed on the embroidery machine to prevent the defect in question. After the placement of the apparatus, the products were checked again. As a result of the calculations, the percentage of the defects in question decreased from 42.41% to 4.6%, and an improvement of 37.81% was achieved with the apparatus developed within the scope of this study.
Research pre-empting parasite adaptation is key to sustainable disease management in aquaculture
Authors: Coates A
Published: January 2023

As the aquaculture sector continues to expand, there is likely to be a growing need to combat infectious diseases. The desire for rapid and effective results means that any concerns about longer-term effects of disease controls are often sidelined. In particular, the well-documented capacity for parasites and pathogens to evolve treatment resistance must not be ignored in aquaculture. Outbreaks of resistant parasites pose significant threats to the environment, as well as to farm production. If an industry wishes to avoid treatment resistance, there must first be committed research into the evolutionary biology of the parasite species. Such research should be incorporated into the early phases of developing and implementing a treatment strategy—the sooner the risk of resistance is identified, the sooner its impacts on aquaculture can be mitigated. Here I discuss a research framework that can help guide this process. A combination of theoretical (reviewing the literature), empirical (testing for heritable resistance) and modelling (simulating evolutionary dynamics) studies is recommended. Armed with the knowledge from these studies, parasite management strategies can then be optimised at a regional scale (e.g. with refugia or treatment combinations) in ways that minimise the potential for adaptation. The interaction between salmonid aquaculture and parasitic sea lice is an ideal case study for this topic, and the insights gained from this system should be considered across aquaculture industries. Nevertheless, there is no one-size-fits-all solution to treatment resistance. For each system, dedicated research into parasite evolutionary biology—with a research framework as a guide—is required for aquaculture to home in on the most sustainable disease management strategies for the future.
THE RELATIONSHIP BETWEEN THE SIZE AND LOCALIZATION OF THE URETERAL STONE AND THE DEGREE OF HYDRONEPHROSIS
Authors: AKÇİÇEK Mehmet , BUĞDAY Muhammet Serdar
Published: January 2023

The aim of our research is to evaluate whether there is a relationship between the degree of hydronephrosis and, the size and location of the stones in the ureter in patients with ureteral stones, with computed tomography (CT). 105 patients who applied to Malatya Training and Research Hospital with the complaint of renal colic and underwent CT scan were included in the study. Hydronephrosis was evaluated by using the system developed by the Society of Fetal Urology. Stone sizes were grouped as <5 mm, 5 – 10 mm, and ≥ 10 mm. The location of the stones were indicated as proximal - middle - distal according to the anatomical parts of the ureters. 61 (58.1%) patients had stones in the distal ureter, 20 (19%) had stones in the middle ureter, and 24 (22.9%) had stones in the proximal ureter. It was determined that the stone size showed significant difference according to the degree of hydronephrosis (p<0.05). There was no significant relationship between the stone location being in the proximal, middle or distal parts of the ureter and the degree of hydronephrosis (p=0.241). While, as the size of ureteral stones increases the degree of hydronephrosis increases, there is no relation with the location of the stone and hydronephrosis.
Diosgenin enhances liposome-enabled nucleic acid delivery and CRISPR/Cas9-mediated gene editing by modulating endocytic pathways
Authors: Lohchania Brijesh , Christopher Abisha Crystal , Arjunan Porkizhi , Mahalingam Gokulnath , Kathirvelu Durga , Prasannan Aishwarya , Venkatesan Vigneshwaran , Taneja Pankaj , KM Mohan Kumar , Thangavel Saravanabhavan , Marepally Srujan
Published: January 2023

The CRISPR/Cas9 system holds great promise in treating genetic diseases, owing to its safe and precise genome editing. However, the major challenges to implementing the technology in clinics lie in transiently limiting the expression of genome editing factors and achieving therapeutically relevant frequencies with fidelity. Recent findings revealed that non-viral vectors could be a potential alternative delivery system to overcome these limitations. In our previous research, we demonstrated that liposomal formulations with amide linker-based cationic lipids and cholesterol were found to be effective in delivering a variety of nucleic acids. In the current study, we screened steroidal sapogenins as an alternative co-lipid to cholesterol in cationic liposomal formulations and found that liposomes with diosgenin (AD, Amide lipid: Diosgenin) further improved nucleic acid delivery efficacy, in particular, delivering Cas9 pDNA and mRNA for efficient genome editing at multiple loci, including AAVS1 and HBB, when compared to amide cholesterol. Mechanistic insights into the endocytosis of lipoplexes revealed that diosgenin facilitated the lipoplexes’ cholesterol-independent and clathrin-mediated endocytosis, which in turn leads to increased intracellular delivery. Our study identifies diosgenin-doped liposomes as an efficient tool to deliver CRISPR/Cas9 system.
Reconstruction with 3D-printed prostheses after type I + II + III internal hemipelvectomy: Finite element analysis and preliminary outcomes
Authors: Guo Zehao , Peng Yongjun , Shen Qiling , Li Jian , He Peng , Yuan Peng , Liu Yulei , Que Yukang , Guo Wei , Hu Yong , Xu Shenglin
Published: January 2023

Background: Prosthetic reconstruction after type I + II+ III internal hemipelvectomy remains challenging due to the lack of osseointegration and presence of giant shear force at the sacroiliac joint. The purpose of this study was to evaluate the biomechanical properties of the novel 3D-printed, custom-made prosthesis with pedicle screw–rod system and sacral tray using finite element analysis.

Methods: Four models that included one intact pelvis were established for validation. Forces of 500 N and 2,000 N were applied, respectively, to simulate static bipedal standing and the most loaded condition during a gait cycle. Biomechanical analysis was performed, and the results were compared; the preliminary outcomes of four patients were recorded.

Results: For the reconstructed hemipelvis, stress was mainly concentrated on the sacral screws, bone–prosthesis interface, and upper endplate of the L5 vertebra. The optimization of the design with the sacral tray structure could decrease the peak stress of the sacral screws by 18.6%, while the maximal stress of the prosthesis increased by 60.7%. The addition of the lumbosacral pedicle–rod system further alleviated stress of the sacral screws and prosthesis by 30.2% and 19.4%, respectively. The site of peak stress was contemporaneously transferred to the connecting rods within an elastic range. In the retrospective clinical study, four patients who had undergone prosthetic reconstruction were included. During a follow-up of 16.6 ± 7.5 months, the walking ability was found preserved in all patients who are still alive and no prosthesis-related complications had occurred except for one hip dislocation. The Musculoskeletal Tumor Society (MSTS) score was found to be 19.5 ± 2.9.

Conclusion: The novel reconstructive system yielded favorable biomechanical characteristics and demonstrated promising preliminary outcomes. The method can be used as a reference for reconstruction after type I + II + III hemipelvectomy.
Novel method for the genomic analysis of PKD1 mutation in autosomal dominant polycystic kidney disease
Authors: Shang Shunlai , Wang Chao , Chen Lang , Shen Wanjun , Xie Yuansheng , Li Wenge , Li Qinggang
Published: January 2023

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease. Although next-generation sequencing (NGS) technology can be used to sequence tens of thousands of DNA molecules simultaneously. It has poor capture efficiency for the six PKD1 pseudogenes and GC-rich regions. Multiplex ligation-dependent probe amplification (MLPA) technology can detect consecutive deletions of exons, but it is less sensitive for single-base mutations. However, pathogenic genes might not be detected in some patients, even when using the above methods. Improving the detection rate of pathogenic genes is an important technical problem hindering clinical diagnosis of ADPKD. Four pedigrees of ADPKD patients with mutation sites not identified by NGS were examined by other methods. First, MLPA was performed. Then, pedigrees in which MLPA did not identify pathogenic genes were subjected to multiplex polymerase chain reaction (MPCR) and targeted region sequencing. Finally, the detected mutation sites were verified by Sanger sequencing. The results showed that MLPA detected the following PKD1 exonic deletion mutations in three pedigrees: PKD1-18 nt–290 nt, PKD1-up-257 nt, PKD1-up-444 nt and PKD1-3 nt–141 nt. A new mutation site was identified through targeted region sequencing in one pedigree: PKD1 NM_001009944: c.151T > C at the protein level, described as p. Cys51Arg. In summary, we established a system of genetic detection and analytical methods, from NGS to MLPA to targeted region sequencing and finally to Sanger sequencing. We combined MPCR and targeted region sequencing for the first time in ADPKD diagnosis, which further improved diagnosis accuracy. Moreover, we identified one new missense mutation and four new deletion mutations.
Hydroxyl transfer versus cyclization reaction in the gas phase: Sequential loss of NH3 and CH2CO from protonated phenylalanine derivatives
Authors: Zheng Mingyu , Zhang Xiaoping , Cheng Yihao , Sun Lili , Zhang Xinglei
Published: January 2023

Collisional activation of protonated phenylalanine derivatives deamination products leads to hydroxyl skeletal rearrangement versus cyclization reaction, and to form hydroxylbenzyl cation via elimination of CH2CO. To better clarify this unusual fragmentation reaction, accurate mass measurements experiments, native isotope experiments, multiple-stage mass spectrometry experiments, different substituents experiments, and density functional theory (DFT) calculations were carried out to investigate the dissociation mechanistic pathways of protonated phenylalanine derivatives deamination products. In route 1, a three-membered ring-opening reaction and a 1,3-hydroxyl transfer (from the carbonyl carbon atom to the interposition carbon atom of carbonyl) occurs to form 3-hydroxy-1-oxo-3-phenylpropan-1-ylium, followed by dissociation to lose CH2CO to give hydroxy (phenyl)methylium. In route 2, a successive cyclization rearrangement reaction and proton transfer occur to form a 2-hydroxylphenylpropionyl cation or protonated 2-hydroxy-4H-benzopyran, followed by dissociation to lose CH2CO or CH≡COH to give 2-hydroxylbenzyl cation. In route 3, a successive hydroxyl transfer (from the carbonyl carbon atom to the ortho carbon atom on benzene) and two stepwise proton transfer (1,2-proton transfer to the ipso-carbon atom of the phenyl ring followed by 1,3-proton transfer to the ortho carbon atom of carbonyl) occurs to form a 2-hydroxylphenylpropionyl cation, which subsequently dissociates to form 2-hydroxylbenzyl cation by elimination of CH2CO. DFT calculations suggested that route 1 was more favorable than route 2 and route 3 from a thermodynamic point of view.
Quantification of phospholipids and glycerides in human milk using ultra-performance liquid chromatography with quadrupole-time-of-flight mass spectrometry
Authors: Liu Yan , Qiao Weicang , Liu Yanpin , Zhao Junying , Liu Qian , Yang Kai , Zhang Minghui , Wang Yaling , Liu Yan , Chen Lijun
Published: January 2023

Human milk lipids, which are an important source of energy and affect growth and development of infants, require a comprehensive method for its qualitative and quantitative analysis. This work describes a method for the analysis of phospholipids, glycerides, free fatty acids and gangliosides in human milk by ultra-performance liquid chromatography using a C18 column with quadrupole-time-of-flight mass spectrometry (Q-TOF-MS). The lipids were extracted by liquid-liquid extraction and phospholipids were separated by solid phase extraction (SPE). The chromatographic columns with two different specifications (4.6 mm × 150 mm, and 3 mm × 50 mm) were used to detect phospholipids and glycerides in human milk, respectively. The sphingolipids and glycerides were analyzed in positive ion mode, and the glycerophospholipids and free fatty acids were analyzed in negative ion mode. Both internal and external standards were used for absolute quantification in this experiment. 483 species of lipids, including phospholipids, glycerides, free fatty acids and gangliosides, in human milk were analyzed using UPLC-Q-TOF-MS with high sensitivity and good linearity, with coefficient of correlation above 0.99, the relative standard deviation of accuracy and precision less than 10%. The results in a large number of human milk samples showed that this method was suitable for qualitative and quantitative analysis of lipids in human milk, even for other mammalian milk and infant formulae.
Efficacy and safety outcomes of long-term anti-thrombotic treatment of chronic coronary artery disease: A systematic review and network meta-analysis
Authors: Adawi Nayrouz , Rotshild Victoria , Yanko Stav , Mowaswes Mohammad , Amir Offer , Haitner Gal , Matok Ilan , Raccah Bruria Hirsh
Published: January 2023

Background

Clopidogrel, prasugrel, ticagrelor, and low-dose rivaroxaban are all optional strategies in conjunction with aspirin for long-term treatment of chronic coronary artery disease. The aim of this research was to assess the efficacy and safety of long-term anti-thrombotic treatment of chronic coronary heart disease.

Methods

PubMed (MEDLINE), Embase, Clinical Trials Registry ClinicalTrials.gov, and The Cochrane Library were searched through November 2021, to identify randomized controlled trials that compared long term anti-thrombotic therapy for coronary heart disease. Data were extracted to assess eligibility by two independent reviewers. Random-effects meta-analysis was used to pool results.

Results

Eleven randomized controlled trials were included (88,462 patients). In a network meta-analysis, the rivaroxaban compared to the clopidogrel regimen showed lower relative risks (RRs) for death of any cause (0.71; 95% confidence interval [CI], 0.52–0.96), major adverse cardiac events (MACE) (0.73; 95% CI, 0.57–0.93), and cerebrovascular events (0.48; 95% CI, 0.30–0.78). The RR of cerebrovascular events was also lower for the rivaroxaban compared to the ticagrelor 60 mg regimen (0.72; 95% CI, 0.52–0.99). For the prasugrel regimen, the RRs were lower of myocardial infarction incidence versus all extended strategies: clopidogrel plus aspirin (0.76; 95% CI, 0.58–0.99), rivaroxaban (0.60; 95% CI, 0.38–0.93), ticagrelor 60 mg (0.61; 95% CI, 0.42–0.89), and ticagrelor 90 mg (0.63; 95% CI, 0.41–0.97). None of the dual strategies were associated with differences in major bleeding compared to the prasugrel regimen.

Conclusions and relevance

The rivaroxaban regimen appeared to be the preferred long-term anti-thrombotic regimen in preventing all-cause mortality. Our available results tend to support the efficacy of extended anti-thrombotic therapy consisting of prasugrel in lowering MI incidence compared to the other strategies, without increased risk of bleeding. However, additional large-scale direct clinical trials are needed to further determine the adequate long-term anti-thrombotic regimens for treating chronic coronary syndrome.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020186583, identifier CRD42020186583.
Mechanosignals in abdominal aortic aneurysms
Authors: Lowis Christiana , Ramara Winaya Aurellia , Kumari Puja , Rivera Cristobal F. , Vlahos John , Hermantara Rio , Pratama Muhammad Yogi , Ramkhelawon Bhama
Published: January 2023

Cumulative evidence has shown that mechanical and frictional forces exert distinct effects in the multi-cellular aortic layers and play a significant role in the development of abdominal aortic aneurysms (AAA). These mechanical cues collectively trigger signaling cascades relying on mechanosensory cellular hubs that regulate vascular remodeling programs leading to the exaggerated degradation of the extracellular matrix (ECM), culminating in lethal aortic rupture. In this review, we provide an update and summarize the current understanding of the mechanotransduction networks in different cell types during AAA development. We focus on different mechanosensors and stressors that accumulate in the AAA sac and the mechanotransduction cascades that contribute to inflammation, oxidative stress, remodeling, and ECM degradation. We provide perspectives on manipulating this mechano-machinery as a new direction for future research in AAA.