bluuebunny/crossref_metadata_2025 huggingface dataset:
Movement Trajectory Recognition of Sign Language Based on Optimized Dynamic Time Warping
Authors: Li Wenguo , Luo Zhizeng , Xi Xugang
Published: August 2020

Movement trajectory recognition is the key link of sign language (SL) translation research, which directly affects the accuracy of SL translation results. A new method is proposed for the accurate recognition of movement trajectory. First, the gesture motion information collected should be converted into a fixed coordinate system by the coordinate transformation. The SL movement trajectory is reconstructed using the adaptive Simpson algorithm to maintain the originality and integrity of the trajectory. The algorithm is then extended to multidimensional time series by using Mahalanobis distance (MD). The activation function of generalized linear regression (GLR) is modified to optimize the dynamic time warping (DTW) algorithm, which ensures that the local shape characteristics are considered for the global amplitude characteristics and avoids the problem of abnormal matching in the process of trajectory recognition. Finally, the similarity measure method is used to calculate the distance between two warped trajectories, to judge whether they are classified to the same category. Experimental results show that this method is effective for the recognition of SL movement trajectory, and the accuracy of trajectory recognition is 86.25%. The difference ratio between the inter-class features and intra-class features of the movement trajectory is 20, and the generalization ability of the algorithm can be effectively improved.
Control of Single-Phase Electrolytic Capacitor-Less Isolated Converter for DC Low Voltage Residential Networks
Authors: Santos Nelson , Silva J. Fernando , Soares Vasco
Published: August 2020

In recent years, there has been a desire to improve electricity generation and consumption, to reach sustainability. Technological solutions today allow a rational use of electricity with good overall performance. Traditionally, from production to distribution, electrical energy is AC-supported for compatibility reasons and easy voltage level transformation. However, nowadays most electric loads need DC power to work properly. A single high-efficiency central AC-DC power converter may be advantageous in eliminating several less efficient AC-DC embedded converters, distributed all over a residential area. This paper presents a new single-phase AC-DC converter using one active bridge (most isolated topologies are based on the dual active bridge concept) and a high-frequency isolation transformer with low-value non-electrolytic capacitors, together with its control system design. The converter can be introduced into future low-voltage DC microgrids for residential buildings, as an alternative to several embedded AC-DC converters. Non-linear control techniques (sliding mode control and the Lyapunov direct method) are employed to guarantee stability in the output DC low voltage with near unity power factor compensation in the AC grid. The designed converter and controllers were simulated using Matlab/Simulink and tested in a lab experimental prototype using digital signal processing (DSP) to evaluate system performance.
Robust Offset-Cancellation Sense Amplifier for an Offset-Canceling Dual-Stage Sensing Circuit in Resistive Nonvolatile Memories
Authors: Na Taehui
Published: August 2020

With technology scaling, achieving a target read yield of resistive nonvolatile memories becomes more difficult due to increased process variation and decreased supply voltage. Recently, an offset-canceling dual-stage sensing circuit (OCDS-SC) has been proposed to improve the read yield by canceling the offset voltage and utilizing a double-sensing-margin structure. In this paper, an offset-canceling zero-sensing-dead-zone sense amplifier (OCZS-SA) combined with the OCDS-SC is proposed to significantly improve the read yield. The OCZS-SA has two major advantages, namely, offset voltage cancellation and a zero sensing dead zone. The Monte Carlo HSPICE simulation results using a 65-nm predictive technology model show that the OCZS-SA achieves 2.1 times smaller offset voltage with a zero sensing dead zone than the conventional latch-type SAs at the cost of an increased area overhead of 1.0% for a subarray size of 128 × 16.
Demagnetization Fault Diagnosis of a PMSM Using Auto-Encoder and K-Means Clustering
Authors: Chang Lien-Kai , Wang Shun-Hong , Tsai Mi-Ching
Published: August 2020

In recent years, many motor fault diagnosis methods have been proposed by analyzing vibration, sound, electrical signals, etc. To detect motor fault without additional sensors, in this study, we developed a fault diagnosis methodology using the signals from a motor servo driver. Based on the servo driver signals, the demagnetization fault diagnosis of permanent magnet synchronous motors (PMSMs) was implemented using an autoencoder and K-means algorithm. In this study, the PMSM demagnetization fault diagnosis was performed in three states: normal, mild demagnetization fault, and severe demagnetization fault. The experimental results indicate that the proposed method can achieve 96% accuracy to reveal the demagnetization of PMSMs.
Continuous OTM 33A Analysis of Controlled Releases of Methane with Various Time Periods, Data Rates and Wind Filters
Authors: Heltzel Robert S. , Zaki Mohammed T. , Gebreslase Aron K. , Abdul-Aziz Omar I. , Johnson Derek R.
Published: August 2020

Other test method (OTM) 33A has been used to quantify emissions from natural gas sites since it was introduced by the Environmental Protection Agency (EPA). The method relies on point source Gaussian (PSG) assumptions to estimate emissions rates from a targeted site or source. However, the method often results in low accuracy (typically ±70%, even under conducive conditions). These accuracies were verified with controlled-release experiments. Typically, controlled releases were performed for short periods (15–20 min) under atmospheric conditions that were ideal for effective plume transport. We examined three methane release rates from three distances over various periods of time ranging from seven hours to seven days. Data were recorded continuously from a stationary tower. Atmospheric conditions were highly variable and not always conducive to conventional OTM 33A calculations. OTM 33A estimates were made for 20-min periods when the mean wind direction corresponded to ±90° of the direction from the controlled release to the tower. Further analyses were performed by varying the frequency of the data, the length of the individual OTM 33A periods and the size of the wind angle used to filter data. The results suggested that different (than conventionally used) period lengths, wind filters, data acquisition frequencies and data quality filters impacted the accuracy of OTM 33A when applied to long term measurements.
Foundry Sand Source Reduction Options: Life Cycle Assessment Evaluation
Authors: Ghormley Samuel , Williams Robert , Dvorak Bruce
Published: August 2020

Foundries represent a significant part of the world’s economy and are a large consumer of energy and producer of solid waste. Sand-handling processes can use 5–10% of a foundry’s total energy. The goal of this research was to explore source reduction and waste minimization at a foundry, using both economic and Life Cycle Assessment (LCA) techniques to compare three secondary sand-reclamation options. LCA software modeled all sand processes at a mid-sized ferrous foundry in the USA. The LCA showed all secondary reclamation technologies, while more energy intensive at the foundry, lowered life cycle environmental impacts, including GHG emissions, ecotoxicity, and human health indicators, due primarily to source reduction and corresponding reduction in transportation both from the virgin sand source and to the landfill. Varying transportation distance had a large impact on LCA results to the point where the life cycle benefit of secondary reclamation became a liability in a zero distance scenario. Varying electricity generation to favor greener sources was also examined, but proved to have minimal impact on the LCA results. This research suggests that the greatest reduction of life cycle impacts in the sand-handling processes for a foundry is to find a geographically closer source for virgin sand.
Genome-Wide DNA Methylation and LncRNA-Associated DNA Methylation in Metformin-Treated and -Untreated Diabetes
Authors: Solomon Wendy , Hector Stanton , Raghubeer Shanel , Erasmus Rajiv , Kengne Andre , Matsha Tandi
Published: September 2020

Metformin, which is used as a first line treatment for type 2 diabetes mellitus (T2DM), has been shown to affect epigenetic patterns. In this study, we investigated the DNA methylation and potential lncRNA modifications in metformin-treated and newly diagnosed adults with T2DM. Genome-wide DNA methylation and lncRNA analysis were performed from the peripheral blood of 12 screen-detected and 12 metformin-treated T2DM individuals followed by gene ontology (GO) and KEGG pathway analysis. Differentially methylated regions (DMRs) observed showed 22 hypermethylated and 11 hypomethylated DMRs between individuals on metformin compared to screen-detected subjects. Amongst the hypomethylated DMR regions were the SLC gene family, specifically, SLC25A35 and SLC28A1. Fifty-seven lncRNA-associated DNA methylation regions included the mitochondrial ATP synthase-coupling factor 6 (ATP5J). Functional gene mapping and pathway analysis identified regions in the axon initial segment (AIS), node of Ranvier, cell periphery, cleavage furrow, cell surface furrow, and stress fiber. In conclusion, our study has identified a number of DMRs and lncRNA-associated DNA methylation regions in metformin-treated T2DM that are potential targets for therapeutic monitoring in patients with diabetes.
Forest Compositional Changes after a Decade of Emerald Ash Borer
Authors: Marshall Jordan M.
Published: August 2020

Emerald ash borer is an invasive pest in North American forests. Ecological impacts of ash mortality from emerald ash borer are wide-ranging, including shifts in insect communities and wildlife behavior. Additionally, loss of ash from forests may have important implications regarding plant succession. Surveys of overstory, midstory, and understory trees within forests in northeastern Indiana, Lower Peninsula of Michigan, and northwestern Ohio were conducted to quantify the change in forest composition over a 10 year period. Interpolation of ash dominance illustrated inversion of live and dead ash values between 2007 and 2017. Even though more than 83% of overstory live ash basal area was lost across the study area, green ash was the most abundant midstory and understory species representing regeneration. Additionally, loss of ash from many of the sites resulted in compositional changes that were greater than merely the subtraction of ash. Due to the relatively large number of forest types with which ash species are associated, loss of ash will have broad ecological consequences, including on community composition.
Mapping QTL Associated with Resistance to Avian Oncogenic Marek’s Disease Virus (MDV) Reveals Major Candidate Genes and Variants
Authors: Smith Jacqueline , Lipkin Ehud , Soller Morris , Fulton Janet E. , Burt David W.
Published: August 2020

Marek’s disease (MD) represents a significant global economic and animal welfare issue. Marek’s disease virus (MDV) is a highly contagious oncogenic and highly immune-suppressive α-herpes virus, which infects chickens, causing neurological effects and tumour formation. Though partially controlled by vaccination, MD continues to have a profound impact on animal health and on the poultry industry. Genetic selection provides an alternative and complementary method to vaccination. However, even after years of study, the genetic mechanisms underlying resistance to MDV remain poorly understood. The Major Histocompatability Complex (MHC) is known to play a role in disease resistance, along with a handful of other non-MHC genes. In this study, one of the largest to date, we used a multi-facetted approach to identify quantitative trait locus regions (QTLR) influencing resistance to MDV, including an F6 population from a full-sib advanced intercross line (FSIL) between two elite commercial layer lines differing in resistance to MDV, RNA-seq information from virus challenged chicks, and genome wide association study (GWAS) from multiple commercial lines. Candidate genomic elements residing in the QTLR were further tested for association with offspring mortality in the face of MDV challenge in eight pure lines of elite egg-layer birds. Thirty-eight QTLR were found on 19 chicken chromosomes. Candidate genes, microRNAs, long non-coding RNAs and potentially functional mutations were identified in these regions. Association tests were carried out in 26 of the QTLR, using eight pure lines of elite egg-layer birds. Numerous candidate genomic elements were strongly associated with MD resistance. Genomic regions significantly associated with resistance to MDV were mapped and candidate genes identified. Various QTLR elements were shown to have a strong genetic association with resistance. These results provide a large number of significant targets for mitigating the effects of MDV infection on both poultry health and the economy, whether by means of selective breeding, improved vaccine design, or gene-editing technologies.
VEGF Expression in Colorectal Cancer Metastatic Lymph Nodes: Clinicopathological Correlation and Prognostic Significance
Authors: Mazeda Inês , Martins Sandra F. , Garcia Eduardo A. , Rodrigues Mesquita , Longatto Adhemar
Published: August 2020

Background: Angiogenesis plays an important role in colorectal cancer (CRC) tumorigenesis and metastatic progression. Methods: The present series consisted of CRC lymph node metastasis (LNM) tissue samples from 210 patients. Archival paraffin embedded LNM tissue were used to build up tissue microarray blocks and VEGF expression was immunohistochemically assessed. Results: VEGF-A and VEGF-C are overexpressed in LNM. VEGF-A was associated with patient age (p < 0.001), and VEGFR-2 and VEGFR-3 with CRC relapse (p = 0.032; p = 0.030, respectively). VEGF-C positivity was associated with VEGFR-3 positivity (p = 0.031), and VEGF-D with VEGFR-2 and VEGFR-3 (p ≤ 0.001). Matching the expression in LNM with CRC, in CRC VEGF-A positivity associates with VEGF-A, VEGF-C, VEGF-D, VEGF-R2, VEGF-R3 positivity in LNM; CRC VEGF-C with VEGF-D, VEGFR-2, VEGFR-3; CRC VEGFR-2 with VEGF-A, VEGF-C, VEGF-D, VEGFR-2, VEGFR-3; CRC VEGFR-3 with VEGF-A, VEGF-C, VEGF-D, VEGFR-2, VEGFR-3 in LNM. Conclusion: This study provides new information, revealing that VEGF family expression is increased in LNM. The association between the expression of VEGFR-2 and VEGFR-3 in LNM with CRC relapse reveals its impact on patient prognosis. Interesting data were found when the relationship between these proteins in primary tumor and their metastasis, were analyzed; VEGFA positivity in primary tumor is positively related to VEGF-A, VEGF-C, VEGF-D, VEGFR-2 and VEGFR-3 in their respective LNM suggesting mutual influence.
Creative Environments: The Geo-Poetics of Allen Ginsberg
Authors: Ferrere Alexandre
Published: September 2020

As was the case for other writers from the Beat Generation, geography is more than simply a setting for Allen Ginsberg’s work, as his poetry also bears the imprint of the influence of the landscapes through which he traveled in his mind and poetic practice. In the 1950s, the same decade which saw the composition of Ginsberg’s Howl, Guy Debord and his followers developed the concept of “psychogeography” and “dérive” to analyze the influence of landscapes on one’s mind. The Debordian concept of psychogeography implies then that an objective world can have unknown and subjective consequences. Inspired by Debord’s theories and through the analysis of key poems, this paper argues that a psychogeographical focus can shed new light on ecocritical studies of Ginsberg’s poetry. It can indeed unveil the complex construction of the poet’s own space-time poetics, from hauntological aspects to his specific composition process.
Medical Characteristics of Foreign Language Patients in Paramedic Care
Authors: Müller Frank , Hummers Eva , Noack Eva Maria
Published: August 2020

Background: In this study, medical and socio-demographic characteristics of foreign language patients in prehospital emergency medical care are analyzed and compared with non-foreign language patients. Methods: We performed retrospective chart review of rescue operations in four emergency medical service stations in Northern Germany over seven months as part of the DICTUM Rescue study (DRKS00016719). We performed descriptive analyses including test statistics and used partial correlation to adjust for patients’ sex and age. Results: Patients with limited German proficiency were served in 2.2% of all 7494 covered rescue operations. On average, these patients were two decades younger than their German speaking counterparts. There were significantly more patients with limited German proficiency with gynecological and obstetric problems, especially births, as well as psychiatric disorders, especially suicide attempts. Conclusions: Our findings suggest that the existing preventive programs for pregnant women and people at risk of suicide do not sufficiently reach patients with limited German proficiency. Additionally, giving birth and psychiatric breakdowns are exceptional and sensitive situations, both for patients and the paramedic staff, where the ability to communicate safely appears to be of enormous importance to enable safe treatment.
The Influence of Markets on the Nutrition Transition of Hunter-Gatherers: Lessons from the Western Amazon
Authors: Donders Isabella , Barriocanal Carles
Published: August 2020

For many centuries, hunter-gatherer societies relied on subsistence practices and traditional diets. However, forces of globalization have increased market involvement, thereby fueling the nutrition transition of hunter-gatherer societies. We review the academic literature on market involvement of hunter-gatherer societies in the Western Amazon and its consequences on diet, health and well-being. First, we elaborate on four main determinants of market involvement (accessibility, monetary income, wild meat trade and social capital), showing how each determinant draws individuals toward or away from markets. Thereafter, we discuss how these determinants alter diet, health and well-being. Our results add to the understanding of the complex relations between market involvement, dietary change, health and well-being of indigenous societies. Furthermore, they bring to light that additional research is needed on the topic to support decision-makers and help preserve indigenous values.
The Driving Factors of EMU Government Bond Yields: The Role of Debt, Liquidity and Fiscal Councils
Authors: Pappas Anastasios , Kostakis Ioannis
Published: September 2020

This study presents empirical evidence about the determinants of long-term government bond yields for 19 economies of the European Monetary Union (EMU) over the period 1995–2018 within a multivariate panel framework. The fixed effects estimators reveal that the relationship between public debt to the GDP ratio and yields is non-linear. We observe a threshold, which is determined to be at the area 90% of the ratio of public debt to GDP. Beyond that, area government borrowing costs increase as the public debt rises. Furthermore, we find evidence that a GDP decline and the downgrades of sovereign ratings increase the costs of government borrowing. In contrast, the operation of independent fiscal institutions helps to reduce government’s debt risk premium. Finally, liquidity in the Euro area plays a significant role on yields determination. The results remain robust when the dynamic instrumental variable fixed effect (FE-2SLS) and dynamic panel least square dummy variable corrected (LSDVC) estimators are employed. Empirical findings suggest important policy implications for the ongoing Covid-19 crisis for the EMU.
Insights on the Interplay between Cells Metabolism and Signaling: A Therapeutic Perspective in Pediatric Acute Leukemias
Authors: Anselmi Laura , Bertuccio Salvatore Nicola , Lonetti Annalisa , Prete Arcangelo , Masetti Riccardo , Pession Andrea
Published: August 2020

Nowadays, thanks to extensive studies and progress in precision medicine, pediatric leukemia has reached an extremely high overall survival rate. Nonetheless, a fraction of relapses and refractory cases is still present, which are frequently correlated with poor prognosis. Although several molecular features of these diseases are known, still the field of energy metabolism, which is widely studied in adult, has not been frequently explored in childhood leukemias. Metabolic reprogramming is a hallmark of cancer and is deeply connected with other genetic and signaling aberrations generally known to be key features of both acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). This review aims to clear the current knowledge on metabolic rewiring in pediatric ALL and AML, also highlighting the influence of the main signaling pathways and suggesting potential ideas to further exploit this field to discover new prognostic biomarkers and, above all, beneficial therapeutic options.
Endocannabinoid-Epigenetic Cross-Talk: A Bridge toward Stress Coping
Authors: Rusconi Francesco , Rubino Tiziana , Battaglioli Elena
Published: August 2020

There is no argument with regard to the physical and psychological stress-related nature of neuropsychiatric disorders. Yet, the mechanisms that facilitate disease onset starting from molecular stress responses are elusive. Environmental stress challenges individuals’ equilibrium, enhancing homeostatic request in the attempt to steer down arousal-instrumental molecular pathways that underlie hypervigilance and anxiety. A relevant homeostatic pathway is the endocannabinoid system (ECS). In this review, we summarize recent discoveries unambiguously listing ECS as a stress coping mechanism. As stress evokes huge excitatory responses in emotional-relevant limbic areas, the ECS limits glutamate release via 2-arachydonilglycerol (2-AG) stress-induced synthesis and retrograde cannabinoid 1 (CB1)-receptor activation at the synapse. However, ECS shows intrinsic vulnerability as 2-AG overstimulation by chronic stress rapidly leads to CB1-receptor desensitization. In this review, we emphasize the protective role of 2-AG in stress-response termination and stress resiliency. Interestingly, we discuss ECS regulation with a further nuclear homeostatic system whose nature is exquisitely epigenetic, orchestrated by Lysine Specific Demethylase 1. We here emphasize a remarkable example of stress-coping network where transcriptional homeostasis subserves synaptic and behavioral adaptation, aiming at reducing psychiatric effects of traumatic experiences.
Neutralization of Lipocalin-2 Diminishes Stroke-Reperfusion Injury
Authors: Wang Guona , Weng Yi-Chinn , Chiang I-Chen , Huang Yu-Ting , Liao Yi-Chu , Chen Yi-Chun , Kao Cheng-Yuan , Liu Yu-Li , Lee Tsong-Hai , Chou Wen-Hai
Published: August 2020

Oxidative stress is a key contributor to the pathogenesis of stroke-reperfusion injury. Neuroinflammatory peptides released after ischemic stroke mediate reperfusion injury. Previous studies, including ours, have shown that lipocalin-2 (LCN2) is secreted in response to cerebral ischemia to promote reperfusion injury. Genetic deletion of LCN2 significantly reduces brain injury after stroke, suggesting that LCN2 is a mediator of reperfusion injury and a potential therapeutic target. Immunotherapy has the potential to harness neuroinflammatory responses and provides neuroprotection against stroke. Here we report that LCN2 was induced on the inner surface of cerebral endothelial cells, neutrophils, and astrocytes that gatekeep the blood–brain barrier (BBB) after stroke. LCN2 monoclonal antibody (mAb) specifically targeted LCN2 in vitro and in vivo, attenuating the induction of LCN2 and pro-inflammatory mediators (iNOS, IL-6, CCL2, and CCL9) after stroke. Administration of LCN2 mAb at 4 h after stroke significantly reduced neurological deficits, cerebral infarction, edema, BBB leakage, and infiltration of neutrophils. The binding epitope of LCN2 mAb was mapped to the β3 and β4 strands, which are responsible for maintaining the integrity of LCN2 cup-shaped structure. These data indicate that LCN2 can be pharmacologically targeted using a specific mAb to reduce reperfusion injury after stroke.
Intratumoral Distribution of Lactate and the Monocarboxylate Transporters 1 and 4 in Human Glioblastoma Multiforme and Their Relationships to Tumor Progression-Associated Markers
Authors: Kubelt Carolin , Peters Sönke , Ahmeti Hajrullah , Huhndorf Monika , Huber Lukas , Cohrs Gesa , Hövener Jan-Bernd , Jansen Olav , Synowitz Michael , Held-Feindt Janka
Published: August 2020

(1) Background: Metabolic reprogramming has been postulated to be one of the hallmarks of cancer, thus representing a promising therapeutic target also in glioblastoma multiforme (GBM). Hypoxic tumor cells produce lactate, and monocarboxylate transporters (MCTs) play an important role in its distribution; (2) Methods: We examined the distribution of lactate by multi voxel magnetic resonance spectroscopic imaging and ELISA in glioblastoma multiforme (GBM) patients. In addition, we investigated the expression and cellular localization of MCT1, MCT4, and of several markers connected to tumor progression by quantitative PCR and immunofluorescence double-staining in human GBM ex vivo tissues; (3) Results: The highest lactate concentration was found at the center of the vital parts of the tumor. Three main GBM groups could be distinguished according to their regional gene expression differences of the investigated genes. MCT1 and MCT4 were found on cells undergoing epithelial to mesenchymal transition and on tumor stem-like cells. GBM cells revealing an expression of cellular dormancy markers, showed positive staining for MCT4; (4) Conclusion: Our findings indicate the existence of individual differences in the regional distribution of MCT1 and MCT4 and suggest that both transporters have distinct connections to GBM progression processes, which could contribute to the drug resistance of MCT-inhibitors.
Noninvasive Testing for Diagnosis of Stable Coronary Artery Disease in the Elderly
Authors: Kozlov Sergey G. , Chernova Olga V. , Gerasimova Elena V. , Ivanova Ekaterina A. , Orekhov Alexander N.
Published: August 2020

Efficient diagnostic approaches to detect coronary artery disease (CAD) in elderly patients are necessary to ensure optimal and timely treatment. The population of suspected CAD patients older than 70 years is especially vulnerable and constantly growing. Finding the optimal diagnostic approach is challenging due to certain features of this population, such as high prevalence of comorbidities, existing contraindications to exercise tests or cognitive decline, which hinders correct assessment of the patient’s situation. Moreover, some symptoms of CAD can have variable significance in the elderly compared to younger adult groups. In this review, we present current recommendations of the United States (US) and European cardiologists’ associations and discuss their applicability for diagnostics in the elderly population. Exercise electrocardiogram (ECG) and exercise stress echocardiography (SE) tests are not feasible for a substantial proportion of elderly patients. Coronary computed tomography angiography (CTA) appears to be an attractive alternative for such patients, but is not universally applicable; for instance, it is problematic in patients with significant calcification of the vessels. Moreover, more studies are needed to compare the results delivered by CTA to those of other diagnostic methods. Future efforts should be focused on comparative studies to better understand the limits and advantages of different diagnostic methods and their combinations. It is possible that some of the currently used diagnostic criteria could be improved to better accommodate the needs of the elderly population.
Cannabinoids and Prostate Cancer: A Systematic Review of Animal Studies
Authors: Singh Kanika , Jamshidi Negar , Zomer Roby , Piva Terrence J. , Mantri Nitin
Published: August 2020

Prostate cancer is a major cause of death among men worldwide. Recent preclinical evidence implicates cannabinoids as powerful regulators of cell growth and differentiation, as well as potential anti-cancer agents. The aim of this review was to evaluate the effect of cannabinoids on in vivo prostate cancer models. The databases searched included PubMed, Embase, Scopus, and Web of Science from inception to August 2020. Articles reporting on the effect of cannabinoids on prostate cancer were deemed eligible. We identified six studies that were all found to be based on in vivo/xenograft animal models. Results: In PC3 and DU145 xenografts, WIN55,212-2 reduced cell proliferation in a dose-dependent manner. Furthermore, in LNCaP xenografts, WIN55,212-2 reduced cell proliferation by 66–69%. PM49, which is a synthetic cannabinoid quinone, was also found to result in a significant inhibition of tumor growth of up to 90% in xenograft models of LNCaP and 40% in xenograft models of PC3 cells, respectively. All studies have reported that the treatment of prostate cancers in in vivo/xenograft models with various cannabinoids decreased the size of the tumor, the outcomes of which depended on the dose and length of treatment. Within the limitation of these identified studies, cannabinoids were shown to reduce the size of prostate cancer tumors in animal models. However, further well-designed and controlled animal studies are warranted to confirm these findings.
Gutenberg Goes Neural: Comparing Features of Dutch Human Translations with Raw Neural Machine Translation Outputs in a Corpus of English Literary Classics
Authors: Webster Rebecca , Fonteyne Margot , Tezcan Arda , Macken Lieve , Daems Joke
Published: August 2020

Due to the growing success of neural machine translation (NMT), many have started to question its applicability within the field of literary translation. In order to grasp the possibilities of NMT, we studied the output of the neural machine system of Google Translate (GNMT) and DeepL when applied to four classic novels translated from English into Dutch. The quality of the NMT systems is discussed by focusing on manual annotations, and we also employed various metrics in order to get an insight into lexical richness, local cohesion, syntactic, and stylistic difference. Firstly, we discovered that a large proportion of the translated sentences contained errors. We also observed a lower level of lexical richness and local cohesion in the NMTs compared to the human translations. In addition, NMTs are more likely to follow the syntactic structure of a source sentence, whereas human translations can differ. Lastly, the human translations deviate from the machine translations in style.
Updates in Stroke Treatment, Diagnostic Methods and Predictors of Outcome
Authors: Katsanos Aristeidis H.
Published: August 2020

In recent years, there have been outstanding achievements in stroke diagnosis and care [...]
Are Further Interventions Needed to Prevent and Manage Hospital-Acquired Hyponatraemia? A Nationwide Cross-Sectional Survey of IV Fluid Prescribing Practices
Authors: Sindahl Per , Overgaard-Steensen Christian , Wallach-Kildemoes Helle , De Bruin Marie Louise , Leufkens Hubert GM , Kemp Kaare , Gardarsdottir Helga
Published: August 2020

Background: Hyponatraemia is associated with increased morbidity, increased mortality and is frequently hospital-acquired due to inappropriate administration of hypotonic fluids. Despite several attempts to minimise the risk, knowledge is lacking as to whether inappropriate prescribing practice continues to be a concern. Methods: A cross-sectional survey was performed in Danish emergency department physicians in spring 2019. Prescribing practices were assessed by means of four clinical scenarios commonly encountered in the emergency department. Thirteen multiple-choice questions were used to measure knowledge. Results: 201 physicians responded corresponding to 55.4% of the total population of physicians working at emergency departments in Denmark. About a quarter reported that they would use hypotonic fluids in patients with increased intracranial pressure and 29.4% would use hypotonic maintenance fluids in children, both of which are against guideline recommendations. Also, 29.4% selected the correct fluid, a 3% hypertonic saline solution, for a patient with hyponatraemia and severe neurological symptoms, which is a medical emergency. Most physicians were unaware of the impact of hypotonic fluids on plasma sodium in acutely ill patients. Conclusion: Inappropriate prescribing practices and limited knowledge of a large number of physicians calls for further interventions to minimise the risk of hospital-acquired hyponatraemia.
Management of a Thin Endometrium by Hysteroscopic Instillation of Platelet-Rich Plasma Into The Endomyometrial Junction: A Pilot Study
Authors: Agarwal Meenu , Mettler Liselotte , Jain Smita , Meshram Sandhya , Günther Veronika , Alkatout Ibrahim
Published: August 2020

In patients whose embryo transfer has been previously canceled due to a thin endometrium, the injection of platelet-rich plasma (PRP) guided by hysteroscopy into the endomyometrial junction improves endometrial thickness and vascularity. This may well serve as a novel approach for the management of these patients. In this study, 32 patients aged between 27 and 39 years, suffering from primary or secondary infertility, were selected for hysteroscopic instillation of PRP. This cross-sectional study included a retrospective assessment of the improvement of endometrial thickness (>7 mm) on the commencement of progesterone treatment in 24 of 32 patients (75%) after hysteroscopy-guided injections of PRP into the subendometrial zone. After PRP instillation, the endometrium was 7 mm or thicker in 24 of 32 patients, and all 24 patients underwent frozen embryo transfer. Moreover, 12 of 24 patients who underwent embryo transfer conceived, whereas 10 had a clinical pregnancy with visualization of cardiac activity at 6 weeks and two had a biochemical pregnancy. Our approach of PRP injection into the subendometrial region is consistent with the histologically proven regeneration of the endometrium from the endomyometrial junction. We observed an improvement of endometrial thickness and higher pregnancy rates in cases of previously canceled embryo transfer due to a thin endometrium.
Influence of Conditioned Media on the Re-Differentiation Capacity of Human Chondrocytes in 3D Spheroid Cultures
Authors: Klinder Annett , Kussauer Sophie , Hiemer Bettina , Wree Andreas , Bader Rainer , Jonitz-Heincke Anika
Published: August 2020

A major challenge of cell-based therapy for cartilage lesions is the preservation of the chondrogenic phenotype during ex vivo cell cultivation. In this in vitro study, the chondro-inductive capacity of two different hyaline cartilage-conditioned cell culture media on human chondrocytes in 3D spheroids was determined. Media were conditioned by incubation of 200 mg/mL vital or devitalized cartilage matrix in growth media over 35 days. The media were analyzed for the content of soluble procollagen type (Col) II and glycosaminoglycans (GAGs) as well as released TGF-β1, IGF-1 and IGFBP3. Unconditioned medium served as a negative control while the positive medium control was supplemented with TGF-β1 and IGF-1. Spheroid cultures prepared from human chondrocytes were cultivated at 37 °C, 5% CO2 and 21% O2 in the respective media and controls. After 14 and 35 days, the deposition of ECM components was evaluated by histological analysis. Vital cartilage-conditioned medium contained significantly higher levels of Col II and active TGF-β1 compared to medium conditioned with the devitalized cartilage matrix. Despite these differences, the incubation with vital as well as devitalized cartilage conditioned medium led to similar results in terms of deposition of proteoglycans and collagen type II, which was used as an indicator of re-differentiation of human chondrocytes in spheroid cultures. However, high density 3D cell cultivation showed a positive influence on re-differentiation.
A Decision Aide for the Risk Stratification of GU Cancer Patients at Risk of SARS-CoV-2 Infection, COVID-19 Related Hospitalization, Intubation, and Mortality
Authors: Lundon Dara J. , Kelly Brian D. , Shukla Devki , Bolton Damien M. , Wiklund Peter , Tewari Ash
Published: August 2020

Treatment decisions for both early and advanced genitourinary (GU) malignancies take into account the risk of dying from the malignancy as well as the risk of death due to other causes such as other co-morbidities. COVID-19 is a new additional and immediate risk to a patient’s morbidity and mortality and there is a need for an accurate assessment as to the potential impact on of this syndrome on GU cancer patients. The aim of this work was to develop a risk tool to identify GU cancer patients at risk of diagnosis, hospitalization, intubation, and mortality from COVID-19. A retrospective case showed a series of GU cancer patients screened for COVID-19 across the Mount Sinai Health System (MSHS). Four hundred eighty-four had a GU malignancy and 149 tested positive for SARS-CoV-2. Demographic and clinical variables of >38,000 patients were available in the institutional database and were utilized to develop decision aides to predict a positive SARS-CoV-2 test, as well as COVID-19-related hospitalization, intubation, and death. A risk tool was developed using a combination of machine learning methods and utilized BMI, temperature, heart rate, respiratory rate, blood pressure, and oxygen saturation. The risk tool for predicting a diagnosis of SARS-CoV-2 had an AUC of 0.83, predicting hospitalization for management of COVID-19 had an AUC of 0.95, predicting patients requiring intubation had an AUC of 0.97, and for predicting COVID-19-related death, the risk tool had an AUC of 0.79. The models had an acceptable calibration and provided a superior net benefit over other common strategies across the entire range of threshold probabilities.
Strategies for Increasing the Productivity of Pulsed Laser Cladding of Hot-Crack Susceptible Nickel-Base Superalloy Inconel 738 LC
Authors: Kästner Christian , Neugebauer Matthias , Schricker Klaus , Bergmann Jean Pierre
Published: August 2020

A novel repair strategy based on decoupled heat source for increasing the productivity of wire-assisted pulsed laser cladding of the γ’-precipitation strengthening nickel-base superalloys Inconel 738 low carbon (IN 738 LC, base material) and Haynes 282 (HS 282, filler material) is presented. The laser beam welding process is supported by the hot-wire technology. The additional energy is utilized to increase the deposition rate of the filler material by increasing feeding rates and well-defining the thermal management in the welding zone. The simultaneous application of laser pulse modulation allows the precise control of the temperature gradients to minimize the hot-crack formation. Accompanying investigations such as high-speed recordings and numerical simulations allow a generalized statement on the influence of the adapted heat management on the resulting weld seam geometry (dilution, aspect ratio and wetting angle) as well as the formation of hot-cracks and lack of fusion between base and filler material. Statistical analysis of the data—the input parameters like laser pulse energy, pulse shape, hot-wire power and wire-feeding rate in conjunction with the objectives like dilution, aspect ratio, wetting angle and hot-cracking behavior—revealed regression functions to predict certain weld seam properties and hence the required input parameters.
Application of the Saffir-Simpson Hurricane Wind Scale to Assess Sand Dune Response to Tropical Storms
Authors: Ellis Jean T. , Harris Michelle E. , Román-Rivera Mayra A. , Ferguson J. Brianna , Tereszkiewicz Peter A. , McGill Sean P.
Published: September 2020

Over one-third of the Earth’s population resides or works within 200 km of the coast. The increasing threat of coastal hazards with predicted climate change will impact many global citizens. Coastal dune systems serve as a natural first line of defense against rising sea levels and coastal storms. This study investigated the volumetric changes of two dune systems on Isle of Palms, South Carolina, USA prior to and following Hurricanes Irma (2017) and Florence (2018), which impacted the island as tropical storms with different characteristics. Irma had relatively high significant wave heights and precipitation, resulting in an average 39% volumetric dune loss. During Florence, a storm where precipitation was low and winds were moderate, net volumetric dune loss averaged 3%. The primary driving force causing dune change during Irma was water (precipitation and storm surge), and during Florence, it was wind (aeolian transport). We suggest that the application of the Saffir-Simpson Hurricane Wind Scale classifications should be reconsidered because different geomorphic responses were measured, despite Irma and Florence both being designated as tropical storms. Site-specific pre- and post-storm studies of the dune morphology and site-specific meteorological measurements of the storm (wind characteristics, storm surge, precipitation) are critically needed.
Design and Application of Buoy Single Point Mooring System with Electro-Optical-Mechanical (EOM) Cable
Authors: Yu Junwei , Zhang Shaowei , Yang Wencai , Xin Yongzhi , Gao Huaining
Published: September 2020

This paper presents the design of a hybrid system named the Mooring Buoys Observation System for Benthic with Electro Optical Mechanical Cable (MBOSBC) for long-term mooring buoy observation in deep oceans. MBOSBC is comprised of three main modules: a surface buoy, a benthic node, and an Electro-Optical-Mechanical (EOM) cable. The Surface buoy provides energy for the entire system, the Benthic node is used to observe scientific phenomena on the seabed, and the Electro-Optical-Mechanical (EOM) cable connects the sea surface buoy and the benthic observation node, serving as the information and power transmission link. This paper provides design criteria for a single point mooring buoy using an EOM cable. The environmental load of the buoy under varying wind, wave, and current conditions is analyzed and the mooring hydrodynamic force of EOM is calculated. After calculating the load of the EOM cable under extreme marine conditions, the hydrodynamic force needed for the system is analyzed. After physically testing the strength of the designed EOM cable, a near-shore test of MBOSBC was carried out, in order to verify that the system has the expected function.
Tribochemistry as an Alternative Synthesis Pathway
Authors: Carlton Hayden , Huitink David , Liang Hong
Published: August 2020

While reactions driven by mechanical force or stress can be labeled mechanochemical, those specifically occurring at a sliding interface inherit the name tribochemical, which stems from the study of friction and wear: tribology. Increased perception of tribochemical reactions has been gained through technological advancement, and the development of new applications remains on-going. This surprising physico-kinetic process offers great potential in novel reaction pathways for synthesis techniques and nanoparticle interactions, and it could prove to be a powerful cross-disciplinary research area among chemists, engineers, and physicists. In this review article, a survey of the history and recent usage of tribochemical reaction pathways is presented, with a focus on forging new compounds and materials with this sustainable synthesis methodology. In addition, an overview of tribochemistry’s current utility as a synthesis pathway is given and compared to that of traditional mechanochemistry.
Enhanced Wound Healing Potential of Primary Human Oral Fibroblasts and Periodontal Ligament Cells Cultured on Four Different Porcine-Derived Collagen Matrices
Authors: Lin Zhikai , Nica Cristina , Sculean Anton , Asparuhova Maria B.
Published: August 2020

Xenogenic collagen-based matrices represent an alternative to subepithelial palatal connective tissue autografts in periodontal and peri-implant soft tissue reconstructions. In the present study, we aimed to investigate the migratory, adhesive, proliferative, and wound-healing potential of primary human oral fibroblasts (hOF) and periodontal ligament cells (hPDL) in response to four commercially available collagen matrices. Non-crosslinked collagen matrix (NCM), crosslinked collagen matrix (CCM), dried acellular dermal matrix (DADM), and hydrated acellular dermal matrix (HADM) were all able to significantly enhance the ability of hPDL and hOF cells to directionally migrate toward the matrices as well as to efficiently repopulate an artificially generated wound gap covered by the matrices. Compared to NCM and DADM, CCM and HADM triggered stronger migratory response. Cells grown on CCM and HADM demonstrated significantly higher proliferative rates compared to cells grown on cell culture plastic, NCM, or DADM. The pro-proliferative effect of the matrices was supported by expression analysis of proliferative markers regulating cell cycle progression. Upregulated expression of genes encoding the adhesive molecules fibronectin, vinculin, CD44 antigen, and the intracellular adhesive molecule-1 was detected in hPDL and hOF cells cultured on each of the four matrices. This may be considered as a prerequisite for good adhesive properties of the four scaffolds ensuring proper cell–matrix and cell–cell interactions. Upregulated expression of genes encoding TGF-β1 and EGF growth factors as well as MMPs in cells grown on each of the four matrices provided support for their pro-proliferative and pro-migratory abilities. The expression of genes encoding the angiogenic factors FGF-2 and VEGF-A was dramatically increased in cells grown on DADM and HADM only, suggesting a good basis for accelerated vascularization of the latter. Altogether, our results support favorable influence of the investigated collagen matrices on the recruitment, attachment, and growth of cell types implicated in oral soft tissue regeneration. Among the four matrices, HADM has consistently exhibited stronger positive effects on the oral cellular behavior. Our data provide solid basis for future investigations on the clinical application of the collagen-based matrices in surgical periodontal therapy.
Analytical Solutions Based on Fourier Cosine Series for the Free Vibrations of Functionally Graded Material Rectangular Mindlin Plates
Authors: Huang Chiung-Shiann , Huang S. H.
Published: August 2020

This study aimed to develop series analytical solutions based on the Mindlin plate theory for the free vibrations of functionally graded material (FGM) rectangular plates. The material properties of FGM rectangular plates are assumed to vary along their thickness, and the volume fractions of the plate constituents are defined by a simple power-law function. The series solutions consist of the Fourier cosine series and auxiliary functions of polynomials. The series solutions were established by satisfying governing equations and boundary conditions in the expanded space of the Fourier cosine series. The proposed solutions were validated through comprehensive convergence studies on the first six vibration frequencies of square plates under four combinations of boundary conditions and through comparison of the obtained convergent results with those in the literature. The convergence studies indicated that the solutions obtained for different modes could converge from the upper or lower bounds to the exact values or in an oscillatory manner. The present solutions were further employed to determine the first six vibration frequencies of FGM rectangular plates with various aspect ratios, thickness-to-width ratios, distributions of material properties and combinations of boundary conditions.