bluuebunny/crossref_metadata_2025 huggingface dataset:
Knowledge About COVID-19, perceived behavior control, subjective norm, and health consciousness on vitamin purchase intention during COVID-19
Authors: Handayani Dwi , Denis Fidita Karya  , Isyrofi Atik Qurrota A’Yunin Al
Published: March 2024

Introduction: The COVID-19 is an infectious disease that has threatened all countries in the world because its transmission is very easy and fast. This is what causes COVID-19 to become a global pandemic. As a result of the global pandemic, people become anxious, afraid and try to protect themselves and their families by taking vitamins. This research focuses on education about covid-19, perceived behavior control, subjective norm, health consciousness on vitamin purchase intention during the pandemic.
Methods: This study was a quantitative research with a cross sectional design. Collecting data using a questionnaire distributed to all provinces in Indonesia and collected as many as 284 respondents. The research data were analyzed using SmartPLS for confirmatory factor analysis.
Results: The results of this study explain that there is a significant relationship between education about covid-19 and perceived behavior control, subjective norms, health consciousness. Subjective norm and health consciousness also have a significant influence on vitamin purchase intention. Meanwhile, perceived behavior control has no significant effect on vitamin purchase intention during the pandemic.
Conclusion: It is important to raise health consciousness with a good knowledge about health. So that the application of healthy living behavior can become a trend and have a positive impact on realizing health independence.
Analysis of influence factors gentle birth labor preparedness self-efficacy in the third-trimester pregnant women
Authors: Fritria Dwi Anggraini  , Yunik Windarti  , Handayani Nanik
Published: March 2024

Background: Gentle birth is one way to prepare mothers to give birth naturally by utilizing all the natural elements (body, mind, and soul), which is expected to minimize both physical and psychological trauma and provide a positive experience from the labor process, a mother must have self-efficacy or belief in herself that the mother can do it. The purpose of this research is to analyze the factors that influence self-efficacy in readiness for Gentle birth.
Method: This research is an explanatory analytical study that analyzes the factors that affect the self-efficacy of Gentle Birth labor. The sample size is 64 pregnant women in the third trimester. Sampling using a simple random sampling technique. The dependent variable is the mother's self-efficacy, and the independent variables are physical condition, experience, social modeling, verbal persuasion, family support and health workers. The instrument used a questionnaire about self-efficacy factors and General Self Efficacy (GSE). Analysis with multivariate logistic regression test with a significance value <0.05.
Result: Based on the statistical test, the results obtained that verbal persuasion affects self-efficacy with p = 0.005, social modeling affects Self Efficacy with p = 0.012, experience affects self-efficacy with p = 0.02, and physical and emotional conditions affect Self Efficacy with p = 0.036 while the characteristics mother has an effect on self-efficacy with p = 0.042.
Conclusion: Verbal persuasion is the most influential role in the mother's self-efficacy in preparing for a gentle birth. Therefore it is important to give verbal persuasion, positive affirmations and suggestions to the mother to increase self-efficacy.
The effect of empowerment of the "Mahatta" Cadre on the health status of the first thousand days of birth
Authors: Kamariyah Nurul , Aditya Putri Rahmadaniar , Nurjannah Siti , Umamah Faridah , Indrika Elke Amanda
Published: March 2024

Introduction: For the past ten years, child malnutrition has been a major national concern in Indonesia.  Although the incidence of stunted toddlers has reduced, more than a fifth of toddlers in Indonesia still have stunted growth, making the issue of stunted toddlers a public health concern. This condition got worst due to the COVID-19 pandemic. In Indonesia, the COVID-19 pandemic has hampered access for mothers and children to optimal health services. Thus, This study aims to assess the effect of empowerment of the "Mahatta" cadre on the health degrees ahead of the first thousand days of birth.
Method: The research design was quasi-experimental, with consecutive sampling techniques to determine. The study was conducted in Sampang City. In this study, we divided into two groups. Each group consists of 58 respondents. The intervention group was a group that got empowerment from Mahatta cadres, and the control group was not.  The instrument used in this study was a questionnaire sheet. The statistical analysis for the analytic study was man Whitney and Wilcoxon and chi-square. The significant p-value was less than 0.05.
Results: The average age in the intervention group (43.59 ± 7.910 years old) was higher than the control group (42.53 ± 8.236 years old). Our findings show an enhancement of the test result in the control group of  Mahatta's health workforce empowerment aspect. The empowerment of Mahatta cadres significantly increases the health status score (p=0.000) in the intervention group. The mean value in the intervention group was even higher than in the control group. This showed the potential for Mahatta cadres to improve the health status of pregnant women and children under two years of age.
Conclusion:  The empowerment of Mahatta cadres significantly increases the health status score in the intervention group.
The correlations between insulin administration on hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor- (VEGF-) in experimental rat myocardium experienced hyperglycemia with hypoxia
Authors: Prasetia Toni , Lipoeto Nur Indrawati , Yanwirasti Yanwirasti , Masrul Masrul , Rusmini Hetti
Published: March 2024

Introduction: Hyperglycemia will lead to the synthesis of endothelium-1, which triggers vasoconstriction, resulting in decreased perfusion and ischemia. This will turn causing hypoxia which can induce hypoxia-inducible factor-1 (HIF-1) to release vascular endothelial growth factor (VEGF). This study aimed to analyze the relationship of HIF-1 expression to VEGF-β in the myocardium of experimental rats experiencing hyperglycemia with hypoxia.
Methods: This research method is purely experimental, all variables are controlled by a post-test only control group design. 30 male Wistar rats aged 3 months with 200–250 g were used. They were divided into two groups using simple random sampling techniques. Before given treatment, blood glucose checks were carried out in both groups. Furthermore, both groups were conditioned to be hyperglycemic and hypoxic for some time. Then, the first group was given insulin while the second group was not given insulin. The expression of HIF-1, VEGF-β was examined using immunohistochemistry. Data analyzed with Spearman test.
 Results: The mean blood glucose in the first group was 174 ± 8.80 mg/dl while the second group was 173.67 ± 10.10 mg/dl. The mean value of HIF-1 in the first group was 63.33 ± 24.97% while the second group was 77.33 ± 12.79%. The mean value of VEGF-β in the first group was 37.33 ± 15.80% and in the second group was 13.67 ± 8.76%.
Conclusion: Changes in HIF-1 expression did not have a significant relationship with the expression of VEGF-β, both in control and treatment.
The effect of the type of thyroidectomy on the incidence of hypothyroidism
Authors: Sagiran  , Jaffariz M. Afif , Ardi Pramono
Published: March 2024

Link of Video Abstract: https://youtu.be/cKF7Miu4D9I
 
Background: Thyroidectomy is the surgical removal of part or all of the thyroid glands. Thyroidectomy is performed to treat thyroid disease which can be in the form of enlargement of the thyroid glands and thyroid cancer. Thyroidectomy is performed to help cure the patient's disease, but after thyroidectomy, there is still the possibility of post-operative complications. One of the common complications that can occur is hypothyroidism. The type of thyroidectomy surgery that generally results in hypothyroidism is near-total or total thyroidectomy.
Methods: An analytic observational study with a cross-sectional design was carried out at PKU Muhammadiyah Gamping Hospital. A total of 50 people who had thyroid problems or diseases and had undergone thyroidectomy surgery were included in the samples. The inclusion criteria for this study were patients aged 20–80 years, with hyperthyroidism or euthyroidism, both outpatients or inpatients. Patients with hypothyroidism and those with thyroid disease are excluded from this study. The research data were analyzed with the Fisher exact test.
Results: Majority of the sex of subjects in this study were female. Most of the subject age groups in this study were in the 20-50 year age group. Hypothyroid complications occur in 8% of subjects. The results of bivariate analysis obtained a significant value
Pilot study of massive open online course (MOOC) implementation in electrocardiography (ECG) learning: perspectives from general practitioners
Authors: Gharini Putrika Prastuti Ratna , Gumilang Rizki Amalia , Hasana Shofuro , Fatimah Vita Arfiana Nurul , Kokasih Orisativa , Supriami Kelvin , Solikhah Hana Maryam
Published: March 2024

Link of Video Abstract: https://youtu.be/N3kTT9WiLNw
 
Background: Cardiovascular disease (CVD) is Indonesia's primary cause of morbidity and mortality. Rapid detection and appropriate treatment of CVD cases are needed to reduce mortality. Electrocardiography (ECG) is a simple examination modality that can detect many cardiac abnormalities. General practitioners are expected to master the interpretation of basic ECG. Massive open online course (MOOC) is a breakthrough that can facilitate profound learning without temporal and physical barriers and support continuing medical education. This pilot study aimed to evaluate the implementation of MOOC in ECG learning among a limited number of general practitioners.
Methods: Consecutive sampling was used to recruit the subjects. Subjects were given ten weeks to finish all modules and quizzes. Pre-test and post-test were taken. User satisfaction was evaluated using a questionnaire. A focused group discussion (FGD) was conducted to explore subjects' learning experiences and perspectives toward the learning system using MOOC.
Results: 17 general practitioners participated in the study, but only seven could finish all the modules and quizzes. All subjects were aged under 30 years old. Those who could complete the course took 10-39 days. Post-test scores were significantly higher than pre-test scores (p=0.038). Although subjects agreed that MOOC was convenient, attractive, and suitable for general practitioners in clinical practice, they demanded an explanation of the quiz answers. They suggested that some modules should be optional.
Conclusion: MOOC learning was suitable for general practitioners to improve their ECG interpretation skills. Some features should be added to increase user satisfaction. A study with extensive subjects is needed to analyze the effectiveness of this ECG course.
The correlation between Anogenital Distance (AGD) and Endometriosis
Authors: Nalley Ricky Ricardo , Abdullah Nusratuddin , Madya Fatmawati , Asni St. Nur , Sriwijaya  , Susiawaty
Published: March 2024

Link of Video Abstract: https://youtu.be/XmIf_eavZto
 
Background: Endometriosis is a disease that causes recurrent chronic pain related to menstruation in around 10% of women of reproductive age. However, current non-invasive diagnostic tools are not sufficiently good at detecting endometriosis. Anogenital Distance (AGD) is a new measurement parameter that is non-invasive and proven to be used to help detect endometriosis. This study aims to assess the ability of AGD in detecting endometriosis.
Methods: This study is a diagnostic test study involving 35 endometriosis patients and 35 controls by comparing the clinical characteristics of the patients and the length of AGD-AF and AGD-AC for both groups. Data were analyzed using SPSS version 22.0 for Windows.
Results: The median AGD-AF length in endometriosis patients and controls were 22.65 + 6.54 and 29.53 + 3.52 (p<0.001) respectively, with AGD-AC lengths being 68.04 + 5.8 and 66.81 + 5.49 (p=0.369). In the multivariate logistic regression test, AGD-AF length was a single significant predictor (p <0.001). Based on the ROC curve, the length of AGD-AF with a cut-off of 23.35 mm has a sensitivity and specificity value of 97.1% and 65.7%.
Conclusion: This study states that there is a correlation between AGD and endometriosis, especially AGD-AF, so it can be used as one of the predictors to help detect endometriosis.
Genomic characterization of reinfection cases in the first wave of the COVID-19 pandemic in Indonesia
Authors: Suwarsono Erike Anggraini , Hendarmin Laifa Annisa , Adhiyanto Chris
Published: March 2024

Link of Video Abstract: https://youtu.be/TRnFAXBESHc
 
Background: Coronavirus disease 2019 (COVID-19) has become a significant disease causing a pandemic worldwide. Many variants were detected within the globe and may have an important role in transmission capability or reinfection conditions. The ‘unknown’ level of immunity’s protection from previous infection and the more virulent virus could lead to reinfection. Using the whole genome sequence, we can analyze the genomic insight within the first and second infections to help understand the reinfection pattern of COVID-19.
Methods: In this study, we investigated three COVID-19 cases with reinfection for primary and secondary infection each. The SARS-CoV-2 confirmation was conducted using qPCR with multiplex gene targets Orf1ab and E. Confirmation of reinfection was done by genomic analysis. Library preparation and sequencing were done using ARTIC protocol using nanopore technology.
Results: There was a wide variety of mutations between two episodes of infection and different clinical manifestations in each episode.
Conclusions: The result concluded that reinfection happened in worsened clinical symptoms and distinct genomic variation in each episode of infection
The association between postpartum perineal laceration with anatomy and pelvic floor muscle strength
Authors: Gosal Gledies Theresye , Irianta Trika , Lotisna David , Sunarno Isharyah , Farid Imam Ahmadi , Pelupessy Nugraha Utama
Published: March 2024

Link of Video Abstract: https://youtu.be/lrnQiVZyH8Q
 
Background: Perineal lacerations damage the tissues around the vagina and rectum and can cause disruption of the anatomy and function of the pelvic floor. The incidence of perineal lacerations after vaginal delivery ranges from 53-89%. This anatomical damage and muscle dysfunction can cause urinary incontinence, anal incontinence, and uterovaginal prolapse. This study aims to evaluate the effects of postpartum perineal lacerations on the anatomy and strength of the pelvic floor muscles.
Methods: The sample of this study is primiparous women who experienced perineal lacerations. Sampling was carried out prospectively using the consecutive sampling method. Pelvic floor anatomy and strength were measured using a POP-Q system and a perineometer. The 1st and 2nd degree laceration group measurements will be compared using the chi-square, and Mann-Whitney tests will be carried out.
Results: Of the 123 research samples that met the criteria, a significant difference was found in the strength of the pelvic floor muscles in the first-degree perineal laceration and second-degree perineal laceration groups at 1st day and 12 weeks postpartum (p = 0.000 and p = 0.042). The only significant difference found for pelvic floor muscle anatomy is in perineal body length at 12 weeks postpartum.
Conclusion: The degree of perineal laceration is related to the strength of the pelvic floor muscles after delivery and the length of the perineal body 12 weeks postpartum.
Correlation between phenotype and cortisol with anxiety status related to Polycystic Ovary Syndrome (PCOS)
Authors: Shulaeha Ummi , Tahir Andi Mardiah , Abdullah Nusratuddin , Sunarno Isharyah
Published: March 2024

Link of Video Abstract: https://youtu.be/VpTspeX7fe0
 
Background: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Symptoms include irregular menstrual cycles, hirsutism, obesity, acne vulgaris, and infertility. PCOS is a stigmatized condition that affects women's identity and mental health, especially anxiety. In addition, increased cortisol is associated with increased anxiety. This study aims to determine the effect of phenotype and cortisol on anxiety status in polycystic ovary syndrome (PCOS) patients.
Methods: 40 patients diagnosed with polycystic ovary syndrome (PCOS) aged 18-40 years in Makassar. The Indonesian version of the Hamilton Anxiety Rating Scale (HAM-A) assesses anxiety. A blood sample is taken to check for cortisol (drip blood test). Cortisol levels were measured using the CMIA (Chemiluminescent microparticle Immunoassay) method. Data were analyzed using SPSS version 25.0 for Windows.
Results: The prevalence of phenotypes A, B, C, and D were 27.5%, 0%, 45%, and 45%, respectively. Phenotype C had a higher body mass index than the other phenotypes but was not significantly different. (p > 0.05). About 26.1% of patients with phenotype A were found to suffer from mild anxiety and 29.5% experienced moderate anxiety. Compared to phenotype C, 52.2% experienced mild anxiety and 35.5% experienced moderate anxiety; however, these results were not statistically significant. Higher cortisol levels were found in phenotype A compared to other phenotypes (phenotype C; 7.01±3.12 and phenotype D; 6.37±3.02) but not significantly different (p>0.05).
Conclusion: The PCOS phenotype has no relationship with the anxiety status of PCOS patients and there is no relationship between the phenotype and serum cortisol levels in PCOS patients.
Coil migration during coronary artery fistula transcatheter embolization
Authors: Homenta Rampengan Starry , Kwandou Willis , Pangemanan Janry A. , Jim Edmond L.
Published: March 2024

Link of Video Abstract: https://youtu.be/qD-dDYr0m2U
 
Introduction: Coronary artery fistula (CAF) transcatheter coil embolization is very effective in treating symptomatic coronary fistula and has many advantages compared to the surgical approach. Although this procedure is considerably safe, some life-threatening complications, including vessel rupture, coil migration and death, could still happen. We reported an example case of coil migration into the left anterior descending (LAD) artery during transcatheter CAF embolization.
Case Description: A 61-year-old man reported recurrent episodes of typical chest pain and a history of inconclusive exercise tests. Computed tomography (CT) angiography revealed a considerable medium size complex coronary fistula from proximal LAD to main pulmonary artery (MPA), which could cause coronary steal syndrome. The patient then underwent CAF transcatheter coil embolization with 3 pushable coils. Upon delivery of the last coil, the coil suddenly migrated into proximal LAD and made the patient feel chest pain with slight ST depression on electrocardiogram (ECG) monitor lead. This coil migration was treated with a coronary stent to pin the coil into the ostial CAF and coronary vessel wall. After the procedure, the chest pain disappeared, and the ST segment on ECG resolved back to baseline.
Conclusion: Coil migration is one of the potentially life-threatening complications during transcatheter CAF coil embolization. Careful preparation in choosing the closure technique, selecting coil size, determining the landing zone and using a detachable coil in high-risk CAF anatomy is mandatory to prevent this event.
Elevated preoperative hemoglobin A1c is associated with higher stage and grade of endometrial carcinoma
Authors: Iskandar Teuku Mirza
Published: March 2024

Introduction: The incidence of endometrial cancer (EC) and diabetes mellitus has been linked in many studies. EC patients had more severely impaired glucose tolerance than individuals with other malignancies. An indicator that determines glycemic index control is hemoglobin A1c (HbA1c). This study aimed to assess whether the preoperative level of HbA1c in diabetes mellitus patients is related to the stage and grade of endometrial carcinoma.
Methods: This cross-sectional study uses a retrospective observational analytic design. Diabetes mellitus patients diagnosed with EC and measured for HbA1c levels in Dr. Kariadi General Hospital Semarang from January 2018 to December 2021 were involved as the subjects of this study. The data was analyzed using correlation analysis and linear regression analysis. A value of p<0.05 was used to determine the statistical significance.
Results: This study involved 27 EC patients who had preoperative HbA1c data. The overall average HbA1c was 7.88±1.35 in the early-stage group and 10.85±1.15 in the advanced-stage group, significantly different between groups (p<0.001). There was also a significant difference between HbA1c in low-grade and high-grade tumors (p<0.001). With an increase of HbA1c in one unit value, the endometrial carcinoma stage also increases by 0.323 units or 32.3%, while the grade of endometrial carcinoma also increases by 0.275 units or 27.5%.
Conclusion: HbA1c level significantly correlates with both the stage and grade of EC. This study also found a linear relationship between increased HbA1c levels and higher stage and grade of EC, indicating that HbA1c levels influence the stage and grade of endometrial carcinoma.
Hematological parameters in streptozotocin-induced diabetic rats and the effect of Rosa damascena Mills. extract
Authors: Jauhar Tamam , Dewi Lestari , Wibowo Prajogo
Published: March 2024

Introduction: Chronic inflammation is the primary factor contributing to the development of diabetes mellitus and its associated problems in affected patients. White blood cells are of significant importance in the degenerative mechanism of blood vessel walls in individuals with diabetes, ultimately leading to the development of atherosclerosis and initiating the rupture of unstable plaques, which subsequently causes thrombosis. Red roses contain anthocyanins, with cyanidin being the specific compound that demonstrates the greatest antioxidant action. The main aim of this study was to investigate the impact of various doses of ethanol extract derived from Rosa Damascena on hematological markers in rats with diabetes.
Methods: This study used an experimental design with a randomized post-test-only control group. A total of twenty male Wistar rats were allocated into five distinct groups for the purpose of this study. The groups were categorized as follows: Healthy Control Group (HCG), Diabetes Group (DG), and Extract Group, which was further separated into three subgroups denoted as P1 (250 mg/kgBW), P2 (500 mg/kgBW), and P3 (1,000 mg/kgBW). The experimental groups received a single injection of streptozotocin at a dosage of 50 mg/kgBW to induce diabetes. Additionally, they were administered oral treatment of Rosa Damascena ethanolic extract for a duration of 2 weeks.
Results: The group denoted as P2 has the lowest NLR, as seen by a mean value of 0.06. In contrast, the group administered with Metformin exhibited the lowest leukocyte value, with a mean of 7.98±6.0. Nevertheless, there are no substantial disparities in the remaining variables.
Conclusion: The results of this study indicate that the ethanol extract obtained from Rosa Damascena did not have a statistically significant effect on the hematological parameters of rats with streptozotocin-induced diabetes.
Hemoptysis in COVID-19 pulmonary embolism patient: a case report
Authors: Bur Rika , Gebrina Meutia , Wildani Muhammad Maulana , Rumondor Bayu Bijaksana , Muchtar Yarmaniani Miliati , Talib Suprohaita Rusdi , Dewi Febby Elvanesa Sandra , Maria Gita
Published: March 2024

Link of video abstract: https://youtu.be/LsOAYx2sZmw
 
Background: Coronavirus disease 2019 (COVID-19) is related to hypercoagulability and venous thromboembolism (VTE). The overlapping symptoms of COVID-19 linked to acute respiratory distress syndrome (ARDS) and COVID-19 with concomitant pulmonary embolism (PE) provide a diagnostic difficulty for emergency physicians. This case study aims to evaluate the hemoptysis in COVID-19 pulmonary embolism patient.
Case presentation: A 46-year-old woman with COVID-19 complained of a bloody cough (estimated 10 ml). She had COVID-19 five days before presenting. Vital signs were normal, but the respiratory rate went 30 times per minute. A lab test revealed 838.64 ng/ml of D-dimer. A chest x-ray showed bilateral lower lobes opacity. The first HRCT showed consolidation with fibrosis and minimal traction bronchiectasis in the 7th and 8th segment of the right lower lobe, an atypical sign of a COVID-19 lesions. The patient was later hospitalized in a negative pressure chamber, given heparin for 72 hours, and discharged on an oral anticoagulant.
Conclusions: This is one of the first reports of segmental PE in a COVID-19 patient with no VTE risk factor. Emergency care doctors must be aware of the possible link between COVID-19 and PE. Hemoptysis is uncommon in PE patients and is seldom documented in COVID-19 infections. All suspected or confirmed COVID-19 patients should begin thromboprophylaxis to avoid morbidity and death.
Herpes zoster and postherpetic neuralgia progression rate: an epidemiological study at Tertiary Hospital in Bali, Indonesia
Authors: Putra Anak Agung Gede Kresna Naria , Karmila I Gusti Agung Dwi , Ketut Kwartantaya Winaya
Published: March 2024

Link of Video Abstract: https://youtu.be/bmHkb4pnp9I
 
Background: Herpes zoster is an infectious disease caused by the reactivation of the latent varicella zoster virus. One of the complications that has the potential to cause long-term problems is post-herpetic neuralgia. This study aims to evaluate the Herpes zoster and postherpetic neuralgia progression rate: an epidemiological study at Tertiary Hospital in Bali, Indonesia
Methods: This is a retrospective descriptive cross-sectional study. The data was obtained from the patient's medical records in Dermatovenereology Clinic at Sanglah General Hospital Denpasar from January 2020 to December 2021. The samples were all new patients diagnosed with herpes zoster and post-herpetic neuralgia. The variable is sex, age, occupation, comorbid, and location. Data were analyzed using SPSS version 25.0 for Windows.
Results: A total of 23 new patients were diagnosed with herpes zoster and the total visit was 132. Most patients were male 12 (52.3% vs 47.7%). The highest age group was more than 65 years old with 12 (51.5%) patients, followed by 45-64 years with 8 (35.6%) patients. The lesion location in most patients was thoracic in 9 patients (38.1%), followed by cervical in 7 patients (29.5%), lumbar in 6 patients (25.8%), and ophthalmic in 1 patient (6.6%). Six patients (26.0%) had comorbid diseases. Ten patients experienced PHN.
Conclusion: Most herpes zoster patients in Dermatovenereology Clinic, Sanglah Hospital from January 2020 to December 2021 were more than 65 years old, predominantly male sex, with the most common location of herpes zoster in the thoracic region 9 patients (38.1%), and 10 patients (43.5%) had PHN.
Correlation of serum ferritin with parathyroid hormone level in patients with transfusion-dependent thalassemia
Authors: Sari Atika Purnama , Bintoro S. Ugroseno Yudho , Ashariati Ami , Novida Hermina , Diansyah M. Noor , Amrita Putu Niken Ayu , Savitri Merlyna , Romadhon Pradana Zaky
Published: March 2024

Introduction: Thalassemia is a rare hereditary condition that causes hemoglobin synthesis deficiency. Recurrent blood transfusion in transfusion-dependent thalassemia (TDT) individuals results in iron overload and deposition in body tissues, leading to endocrine malfunctions, including parathyroid. This study aimed to determine the correlation between the level of serum ferritin and parathyroid hormone level in TDT patients.
Methods: A cross-sectional study was conducted among adult TDT patients receiving blood transfusions at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia from January to June 2023. Serum ferritin was measured using an enzyme-linked fluorescence assay (ELFA), while parathyroid hormone was quantified using an enzyme-linked immunosorbent assay (ELISA). The Spearman correlation analysis was used to identify the correlation between the level of serum ferritin with parathyroid hormone.
Results: A total of 46 TDT patients were enrolled in the study, with a median age of 25 years old and represented predominantly by males (56.5%). The median levels of serum ferritin and parathyroid hormone were 5,672.90 ng/mL (min-max: 596.80–24,014.58 ng/mL) and 29.80 pg/mL (min-max: 10.61–97.01 pg/mL), respectively. The Spearman correlation analysis suggested a statistically insignificant negative correlation between serum ferritin and parathyroid hormone in TDT patients (r = -0.166; p=0.270).
Conclusion: Serum ferritin was inversely, but not significantly, correlated with parathyroid hormone in TDT patients, suggesting that impaired parathyroid function might be associated with the increment of plasma iron.
Comparison of cerebrospinal fluid results analysis against meningitis pathogens in meningitis patients
Authors: Mukti Magendi Indra , Aryati  , Sugianto Paulus
Published: March 2024

Introduction: Meningitis is a major contributor to global mortality and morbidity rates. The rapid diagnosis of its etiology is crucial. Cerebrospinal fluid (CSF) analysis plays a key role in this process. This study aims to compare CSF analysis results with the Biofire Filmarray ME panel to expedite and simplify the diagnosis of meningitis etiology.
Method: Using an observational analytical cross-sectional design, the study was conducted over 4 months. CSF samples were collected from multiple hospitals. The CSF analysis involved flow cytometry using Sysmex XN 1000 and Dimension EXL platforms. The Biofire Filmarray ME panel employed multiplex PCR technology.
Result: Of the 30 samples, 83.3% exhibited clear appearance, 93.3% lacked clots, and 83.3% were clear in color. Increased cell counts were noted in 56.7% of samples, elevated protein levels in 43.3%, and normal glucose levels in 56.7%. CSF analysis interpretations indicated 70% normal, 3.3% viral infection, and 26.7% bacterial infection. The Biofire Filmarray ME panel results showed 96.7% negatives and 3.3% positive for Cytomegalovirus. Comparing CSF analysis with Biofire Filmarray ME panel results using McNemar's test indicated significant differences. The study highlighted the quality assurance of CSF analysis, challenges of antibiotic use, low prevalence of pathogens detected by the Biofire Filmarray, and the potential for false negatives due to untargeted pathogens.
Conclusion: In conclusion, this study provides insights into CSF analysis and its comparison with the Biofire Filmarray ME panel. However, limitations include the Biofire Filmarray's inability to detect all pathogens and absence of certain data during CSF sampling. Further improvements are needed to enhance accuracy in meningitis diagnosis..
Rheumatoid Vasculitis and Blepharitis Caused By Rheumatoid Arthritis In 6 Years Old Boy: A Case Report
Authors: Lawang Sitti Aizah , Hakka Hasriani Muhammad , Nurdin Mulawardi Muhammad , Maulani Destya
Published: March 2024

Link of Video Abstract: https://youtu.be/4Guk_6foSxw
 
Introduction: Rheumatoid Vasculitis (RV) is a rare complication affecting approximately 1% of patients with severe rheumatoid arthritis. This condition is an extra-articular manifestation of rheumatoid arthritis that affects the small and medium arteries in the body. Vasculitis is an inflammatory necrotizing vascular wall disease that can occur in autoimmune disease. This inflammation leads to damage in blood vessels due to stenosis or occlusion and thrombosis, resulting in pain, necrosis, and aneurysm. Inflammation can be primary or secondary. Skin, fingers, peripheral nerves, eyes and the heart are the most commonly affected areas.
Case description: We report a case of a 6-year-old boy who presented RV and blepharitis. The patient subsequently experienced nail fold infarcts and gangrene of his left finger. He was found to fulfill Jones Criteria, and treatment with aspirin and corticosteroids significantly improved his symptoms. This rare case describes the early onset of rheumatoid vasculitis in a patient with rheumatoid arthritis. Rheumatoid vasculitis is a systemic disease that develops from rheumatoid arthritis with rheumatoid autoantibodies and extra-articular manifestations characterized by tissue damage or ischemia involving the skin and peripheral nerves. The incidence of rheumatoid vasculitis in children is less than 1%, with  12 to  53 cases per 100,000 children under 17 years old.
Conclusion: Rheumatoid vasculitis is a rare complication of rheumatoid. This condition occurs in patients who have rheumatoid arthritis for a long period. The patient will prevent further complications with early diagnostic and proper treatment.
Scoring system for predicting the Post-Operative Atrial Fibrillation (POAF) in post-cardiac surgery: a literature review
Authors: Puspitasari Rahajeng Arianggarini , Sembiring Yan Efrata , Sembiring Joan Angelina
Published: March 2024

Link of Video Abstract: https://youtu.be/tl9Q8g6DUdcBackground: Coronary artery bypass grafting (CABG) is still one of the optimal treatment options for revascularization in coronary heart disease. Despite Atrial Fibrillation being the most common arrhythmia after CABG, there’s still no agreement on which risk assessment to predict the incidence of Post Operative Atrial Fibrillation (POAF).  Some studies have shown that the findings of Atrial fibrillation after CABG are associated with increased hemodynamic disturbances, thromboembolic manifestations, readmission to the Intensive Care Unit (ICU), increased length of stay, organ failure, and death. This study aims to analyze the scoring system used for predicting the incidence of POAF in cardiac surgery.
Methods:  This study used “POAF” AND “Scoring system," AND "CABG” AND “Atrial Fibrillation” as keywords to explore the literature from PubMed, Google Scholar, ProQuest, and Clinical Key. Search engines were searched for relevant papers from the last 15 years.
Result: CHA2DS2-VASc score has a sensitivity of 74.2%, a specificity of 44.7% and can identify patients who are predicted to have a high risk of experiencing POAF by 49.4%. The CHA2DS2-VASc score can be used as an independent predictor for predicting POAF. HATCH score cut-off point exceeding 1 was linked to AF prediction, yielding a sensitivity of 42% and specificity of 70%. POAF Score, the scoring system anticipates an increased likelihood of POAF development (58.5%). A score of 1 corresponds to a 30.1% probability of POAF occurrence and is a practical point for commencing preventive therapy.
Conclusion: Despite the various scoring systems used to predict postoperative atrial fibrillation, including the CHA2DS2-VASc score, HATCH score and Mariscalco. POAF Score demonstrated a validated ability to predict POAF.
Supplementation of vitamin D reduces energy intake and prevents body fatness accumulation in obese woman
Authors: Sinto Linda , I Wayan Weta  , Komang Bagus Satriasa  , Nyoman Mantik Astawa
Published: March 2024

Link of Video Abstract: https://youtu.be/bqtP9eagX1E
 
Introduction: Obese people are at higher risk of comorbidities, including metabolic syndrome, autoimmune, tumor progression and other inflammation diseases because of low-grade chronic inflammation. Vitamin D is closely related to transcriptional activity in adipose tissue, which regulates adipogenesis, inflammatory pathways, and adipose cell metabolism. This research aims to know the effect of Vitamin D supplementation on energy intake and body fat accumulation.
Methods: 40 obese women between the ages of 26 and 45 were randomly assigned to the Intervention and Control groups, which received daily supplements of 5000 IU of vitamin D and a placebo, respectively. Data were gathered before the intervention and after 12 weeks of it. We measured the energy intake, BMI, waist circumference (WC), and conicity index. The participants were told to keep their daily calorie consumption at or below 1500 kcal.
Results: After 12 weeks of supplementation, 25(OH) Vitamin D levels increased significantly (p=0.001), and energy intake decreased (p=0.014) significantly in the intervention group, but no change in the control group (p>0,05). Body fatness indices (BMI and WC) increased (p=0.005 and p=0.003) significantly in the control group; however, these parameters did not change in the intervention group (p>0.05).
Conclusion: Daily Vitamin D 5000 IU for 12 weeks decreases energy intake and prevents body fat accumulation in obese women.
A systematic review of natural resistance-associated macrophage protein 1 (NRAMP1) gene and susceptibility to tuberculosis: What is the link for ocular tuberculosis?
Authors: Amalius Ahmad Ashraf , Budu  , Massi Muh. Nasrum , Umar Batari Todja , Minhajat Rahmawati , Muis Mirna , Handayani Irda , Hidayah Najdah
Published: March 2024

Link of Video Abstract: https://youtu.be/hxFKCtWwc3c
 
Introduction: The host genetic factors play a crucial role in determining susceptibility to tuberculosis (TB), and one such candidate gene is Natural Resistance-Associated Macrophage Protein 1 (NRAMP1). NRAMP1 is involved in the regulation of intracellular iron homeostasis, an essential nutrient for MTb survival within macrophages. Several polymorphisms of the NRAMP1 gene have been extensively studied for their association with TB susceptibility. However, the specific role of these NRAMP1 gene polymorphisms in the development of ocular tuberculosis, a rare but potentially severe form of TB, remains poorly understood.
Methods: This study was a systematic review conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA). A comprehensive search was performed in the PubMed, Cochrane, and Science Direct databases for original, full-text studies of NRAMP1 gene related to tuberculosis infection. Ethnic, polymorphisms of NRAMP1 evaluated, and its association to TB susceptibility were recorded and summarized qualitatively.
Results: There were 41 studies included in our systematic review. No study of NRAMP1 gene polymorphism in regards to ocular tuberculosis was found. Polymorphisms of the NRAMP1 gene, such as 3'UTR TGTG ins/del, D543N, INT4, and (GT)n, have been investigated for their potential role in determining the susceptibility or immunity to Mycobacterium tuberculosis infection. However, the findings regarding the relationship between NRAMP1 gene polymorphism and tuberculosis are still inconsistent, with controversies and discrepancies among different studies.
Conclusion: NRAMP1 gene polymorphisms showed important involvement to tuberculosis infection susceptibility, therefore its relation to ocular tuberculosis is suggested.
Three years’ experience of tuberculosis versus non-tuberculosis cases of bronchopleural fistula repair at Dr. Soetomo General Academic Hospital Surabaya
Authors: Giriastawa I Gusti Bagus Chandogya , Winarno Dhihintia Jiwangga Suta , Rizki Mohamad
Published: March 2024

Link of Video Abstract: https://youtu.be/DVqGIPOyWR0
 
Background: Tuberculosis (TB) continues to be a significant health issue and causes various complications, especially in developing countries. Bronchopleural fistula (BPF) is a rare and potentially life-threatening complication of pulmonary tuberculosis that needs to be treated by surgical procedure. This research aimed to compare the outcome of post-operative BPF repair caused by Tuberculosis and non-Tuberculosis cases.
Methods: In this retrospective review, we include patients from post-operative repair of BPF with Tuberculosis and non-Tuberculosis cases from January 2020 to December 2022 who were admitted to our primary center. Preoperative, operative and postoperative data were collected from medical records. We identified 36 patients and analyzed the differences between TB and non-TB groups.
Results: There were 36 patients with BPF who underwent surgery. The mean age of the subjects was 47.940±15.288 years. Out of these, 25 subjects (69.4%) had TB, while 11 (30.6%) subjects did not. Among the subjects, 14 TB patients (38.9%) and 2 non-TB patients (56%) experienced recurrent pneumothorax before surgery. Statistical analysis showed a significant association between comorbid TB and the occurrence of secondary attack BPF before surgery (p = 0.035). Regarding the duration of post-operative drain placement, 22 TB patients (61.1%) had the drain placed for less than 7 days, while 3 subjects (8.3%) had it for more than 7 days. Among the non-TB patients, 10 subjects (27.8%) had the drain placed for less than 7 days, and only 1 subject (2.8%) had it for more than 7 days. The statistical analysis showed no association between the TB group and the duration of post-operative drain placement (p=0.798).
Conclusion: There are numerous post-operative complications and morbidities following BPF repair surgery. Patients with TB who undergo BPF repair surgery are significantly associated with secondary attack BPF before surgery.
Profile of ameloblastoma patients at Dr. Soetomo general hospital, Surabaya: A descriptive study
Authors: Hidayat Muhammad Furqan , Marjono Dwi Wibowo
Published: March 2024

Link of Video Abstract: https://youtu.be/_nqEUazGnE0
 
Background: Ameloblastoma is a rare odontogenic epithelial tumor affecting the jawbone (maxilla or mandible). According to the WHO in 2005, there are four different classifications of ameloblastoma: solid or multicystic, unicystic, peripheral, and desmoplastic. Despite being benign, ameloblastoma can seriously damage bones, resulting in deformity and even death. This research aims to know the profile of ameloblastoma due to limited data in Indonesia.
Methods: This study is an observational descriptive study. Cross-sectional data collection was used. Information was gathered from the medical records of patients with ameloblastoma treated at Dr. Soetomo general hospital, Surabaya between January 2018 and December 2022. A descriptive analysis was conducted to determine the frequency and proportion of each research variable.
Results: Forty-two ameloblastoma patients participated in the study. Patients with ameloblastoma ranged in age from 14 to 75, with a mean age of 39.6 (15.7) years. The majority of patients (57.1%) were female. The majority of the cases were mandibular ameloblastoma. Only 4.8% of ameloblastoma cases occurred in the maxilla, while 76.2% of ameloblastoma locations were found in the left mandible. Up to 97.61% of the surgeries conducted include extensive resection. Most patients (95.2%) with ameloblastoma had successful outcomes.
Conclusion: Although rare, the profile of ameloblastoma patients reveals that there are still incidences of fatality, necessitating further discussion of patient mortality risk factors.
Epidemiological description of the risk factors for obstetric emergencies in cross-referral cases at Dr. Soetomo Regional Public Hospital during the COVID-19 pandemic from 2020 to 2021
Authors: Heky Albar , Prasetyo Budi , Damayanti Hanifa Erlin , Djuari Lilik
Published: March 2024

Link Of Video Abstract: https://youtu.be/zIVTZc6xl_8
 
Introduction: Emergency obstetric referrals are crucial for preventing pregnancy complications that may escalate into severe, life-threatening conditions, ultimately resulting in fatalities. The pandemic influenced the obstetric referral system of healthcare services. Specifically, Dr. Soetomo Regional Public Hospital recorded 107 cross-referral cases in 2020 and 58 in 2021 with obstetric risk factors. In this study, we analyze these obstetric emergency cross-referral cases during the pandemic at the hospital. This study aims to provide an epidemiological description of cross-referral cases with risk factors for obstetric emergencies at Dr. Soetomo Regional Public Hospital during the COVID-19 pandemic from 2020 to 2021.
Methods: An analytical descriptive research design, employing a case study approach, was used to analyze cross-referral cases with risk factors for obstetric emergencies over the pandemic period. The research subjects encompassed all obstetric emergency cross-referral cases at Dr. Soetomo Regional Public Hospital during the pandemic, with a total sampling technique applied to select cases that met specific inclusion and exclusion criteria.
Results: The analysis of emergency obstetric referrals revealed a significant relationship between the patient’s age and their risk factor categories for obstetric emergencies (p < 0.001). Furthermore, a significant correlation was found between the delayed referral phases and the risk factors for obstetric emergencies (p < 0.001). A significant correlation was observed concerning the need for Intensive Care Unit (ICU) care. The analysis also demonstrated a significant relationship between obstetric emergencies and birth weight as well as APGAR score (p < 0.05).
Conclusion: This study reveals a compelling relationship between the risk factors for obstetric emergencies and the variables such as age, methods of vaginal delivery, delayed referral phases, birth weights, and APGAR scores during the COVID-19 pandemic.
Ascorbic acid and calcitriol reduce TNF-α to improve the viability of modified McFarlane random skin flaps in Wistar rats
Authors: Santoso Rosalyn Devina , Hamid Agus Roy Rusly Hariantana , Mahadewa Tjokorda Gde Bagus , Sanjaya I Gusti Putu Hendra , Budayanti Ni Nyoman Sri , Herawati Sianny
Published: March 2024

Link of Video Abstract: https://youtu.be/8UIEdUv8za8
 
Introduction: Distal flap necrosis is one of the most common complications in flap procedure. Ascorbic acid (vitamin C) is one of the most widespread antioxidants available, while calcitriol, a metabolite of vitamin D, has anti-inflammatory and antioxidant properties. The purpose of this study was to determine the effect of ascorbic acid and calcitriol on the viability of Modified McFarlane random skin flaps in Wistar rats and its mechanism through suppression of proinflammatory cytokine Tumor Necrosis Factor-α (TNF-α).
Methods: An experimental study used 28 Wistar rats, by creating a caudally based 3 cm x 9 cm Modified McFarlane random skin flap and divided into four groups. The first group was injected with 200 mg/kg/day ascorbic acid, the second group with 2μg/kg/day calcitriol, and the third group with 200 mg/kg/day ascorbic acid combined with 2μg/kg/day calcitriol was injected two hours after flap elevation for seven days, respectively. The control group was not given any intraperitoneal injection. After seven days, the percentage of flap viability rate was measured and tissue sampling was performed to measure the amount of capillary density and TNF-α in all groups.
Results: The higher percentage of viable flap area was found in all treatment groups, the highest in the ascorbic acid group 80.63% (p<0.001). The highest capillary density was found in ascorbic acid combined with the calcitriol group (27/visual field, p<0.001) compared to all groups. It was also found that the amount of TNF-α in the tissue was lowest in the group administered by ascorbic acid combined with calcitriol compared to all groups 57.38 ng/L and 0.62 nmol/mL respectively compared to all groups (p<0.001). The higher percentage of viable flap area was correlated with a lower amount of TNF-α (p<0.001), but not correlated with the amount of capillary density (p>0.05).
Conclusion: Ascorbic acid in combination with calcitriol improves the viability of Modified McFarlane random skin flaps by lowering TNF-α levels.