bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary table 1 from Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis
Authors: Housseau Franck , Wu Shaoguang , Wick Elizabeth C. , Fan Hongni , Wu Xinqun , Llosa Nicolas J. , Smith Kellie N. , Tam Ada , Ganguly Sudipto , Wanyiri Jane W. , Iyadorai Thevambiga , Malik Ausama A. , Roslani April C. , Vadivelu Jamunarani S. , Van Meerbeke Sara , Huso David L. , Pardoll Drew M. , Sears Cynthia L.
Published: March 2023

Supplementary Table S1. List of antibody clones used for flow cytometry analysis.
Supplementary figures from Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis
Authors: Housseau Franck , Wu Shaoguang , Wick Elizabeth C. , Fan Hongni , Wu Xinqun , Llosa Nicolas J. , Smith Kellie N. , Tam Ada , Ganguly Sudipto , Wanyiri Jane W. , Iyadorai Thevambiga , Malik Ausama A. , Roslani April C. , Vadivelu Jamunarani S. , Van Meerbeke Sara , Huso David L. , Pardoll Drew M. , Sears Cynthia L.
Published: March 2023

Supplementary Figure S1. IL-17-producing cells in C57BL/6 WT mice 7 days after ETBF colonization. Supplementary Figure S2. CD3+ cell recovery from distal colon of WT (CD4Stat3+/+), and CD4Stat3-/- C57BL/6 mice one week after ETBF colonization. Supplementary Figure S3. pStat3 scores in immune cells (IC) and colon epithelial cells do not differ between C57BL/6-CD4Stat3-/- and C57BL/6-CD4Stat3+/+ 3 and 7 days after ETBF colonization . Supplementary Figure S4. Gene expression analysis in distal colon tissue collected from WT (CD4Stat3+/+) (, CD4Stat3-/- and γδ-- - CD4Stat3-/- C57BL/6 mice 7 days after ETBF colonization. Supplementary Figure S5. Difference in IL-17 expression by CD4+ T cells (Th17), γδ+ T cells (γδ T17) and non Th17, non γδT17 cells in the distal colon of WT (CD4Stat3+/+) C57BL/6 mice 7 days after ETBF colonization. Supplementary Figure S6. Macroscopic tumor size distribution in 3 month-ETBF colonized parental Min (Min-CD4Stat3+/+) versus Min-CD4Stat3-/- mice. Supplementary Figure S7. Parental (CD4Stat3+/+) and CD4Stat3-/- Min mice were treated with anti-IL17 mAb between week 6 and 12 following ETBF colonization. Supplementary Figure S8. Myeloid cells accumulation (CD11b+) in colon tumors compared to whole distal colons (tumor and normal tissues) of 3 month ETBF-colonized Min mice. Supplementary Figure S9. Innate lymphoid cells (ILC) reconstitute the lamina propria of BM chimera mice.
Figure S6 from Heme Oxygenase-1 Controls an HDAC4-miR-206 Pathway of Oxidative Stress in Rhabdomyosarcoma
Authors: Ciesla Maciej , Marona Paulina , Kozakowska Magdalena , Jez Mateusz , Seczynska Marta , Loboda Agnieszka , Bukowska-Strakova Karolina , Szade Agata , Walawender Magdalena , Kusior Magdalena , Stepniewski Jacek , Szade Krzysztof , Krist Bart , Yagensky Oleksandr , Urbanik Aleksandra , Kazanowska Bernarda , Dulak Jozef , Jozkowicz Alicja
Published: March 2023

Comparison of eRMS (RD) and aRMS (RH5, RH18, RH28) cell lines cultured under standard conditions.
Figure S5 from Heme Oxygenase-1 Controls an HDAC4-miR-206 Pathway of Oxidative Stress in Rhabdomyosarcoma
Authors: Ciesla Maciej , Marona Paulina , Kozakowska Magdalena , Jez Mateusz , Seczynska Marta , Loboda Agnieszka , Bukowska-Strakova Karolina , Szade Agata , Walawender Magdalena , Kusior Magdalena , Stepniewski Jacek , Szade Krzysztof , Krist Bart , Yagensky Oleksandr , Urbanik Aleksandra , Kazanowska Bernarda , Dulak Jozef , Jozkowicz Alicja
Published: March 2023

Effect of miR-206 on expression of differentiation markers in SMS-CTR eRMS (SMS) and CW9019 aRMS (CW) cell lines.
Supplementary table 1 from Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer
Authors: Regan Anderson Tarah M. , Ma Shi Hong , Raj Ganesh V. , Cidlowski John A. , Helle Taylor M. , Knutson Todd P. , Krutilina Raisa I. , Seagroves Tiffany N. , Lange Carol A.
Published: March 2023

Clinicopathological characteristics of TNBC explant tumors.
Figure S3 from Heme Oxygenase-1 Controls an HDAC4-miR-206 Pathway of Oxidative Stress in Rhabdomyosarcoma
Authors: Ciesla Maciej , Marona Paulina , Kozakowska Magdalena , Jez Mateusz , Seczynska Marta , Loboda Agnieszka , Bukowska-Strakova Karolina , Szade Agata , Walawender Magdalena , Kusior Magdalena , Stepniewski Jacek , Szade Krzysztof , Krist Bart , Yagensky Oleksandr , Urbanik Aleksandra , Kazanowska Bernarda , Dulak Jozef , Jozkowicz Alicja
Published: March 2023

Effect of SnPP (10 μM, 24 h) on RMS cell lines. A - Expression of cMET, HGF, CXCR4 and SDF1 mRNAs in CW9019 aRMS cell line.
Figure S2 from Heme Oxygenase-1 Controls an HDAC4-miR-206 Pathway of Oxidative Stress in Rhabdomyosarcoma
Authors: Ciesla Maciej , Marona Paulina , Kozakowska Magdalena , Jez Mateusz , Seczynska Marta , Loboda Agnieszka , Bukowska-Strakova Karolina , Szade Agata , Walawender Magdalena , Kusior Magdalena , Stepniewski Jacek , Szade Krzysztof , Krist Bart , Yagensky Oleksandr , Urbanik Aleksandra , Kazanowska Bernarda , Dulak Jozef , Jozkowicz Alicja
Published: March 2023

Expression of miR-328, miR-338-3p and miR-485-5p in SMS-CTR eRMS (SMS) and CW9019 aRMS (CW).
Supplementary Figure 1 from Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer
Authors: Regan Anderson Tarah M. , Ma Shi Hong , Raj Ganesh V. , Cidlowski John A. , Helle Taylor M. , Knutson Todd P. , Krutilina Raisa I. , Seagroves Tiffany N. , Lange Carol A.
Published: March 2023

Dex regulation of Brk mRNA and protein in TNBC cell lines and explants.
Supplemental text - unmarked from Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells
Authors: Cheng Gang , Zielonka Jacek , Ouari Olivier , Lopez Marcos , McAllister Donna , Boyle Kathleen , Barrios Christy S. , Weber James J. , Johnson Bryon D. , Hardy Micael , Dwinell Michael B. , Kalyanaraman Balaraman
Published: March 2023

Supplemental text - unmarked
Supplemental figures from Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells
Authors: Cheng Gang , Zielonka Jacek , Ouari Olivier , Lopez Marcos , McAllister Donna , Boyle Kathleen , Barrios Christy S. , Weber James J. , Johnson Bryon D. , Hardy Micael , Dwinell Michael B. , Kalyanaraman Balaraman
Published: March 2023

Supplemental Figure 1: Chemical structures of mitochondria-targeted metformin analogs and the synthetic pathway. Supplemental Figure 2: Effects of Met and Mito-Met10 on proliferation of mouse pancreatic cancer cells. Supplemental Figure 3: The effects of Mito-Met10, Met and other mitochondria-targeted agents (MTAs) on intracellular ATP level and cell death in MiaPaCa-2 cells. Supplemental Figure 4: Mito-Met10, but not control long chain compound (Dec-TPP+), exhibits selectivity in inhibition of cancer cell viability. Supplemental Figure 5: Effects of Mito-Met2 and Mito-Met6 on PDAC proliferation. Supplemental Figure 6: Intracellular concentrations of Mito-Met10 in cancer and normal cells. Supplemental Figure 7: Intracellular redox signaling in Mito-Met10-treated PDAC cells. Supplemental Figure 8: Measurement of respiratory activity in permeabilized cells using extracellular flux analysis and effects of Mito-Met10 and Met on mitochondrial complex I activity. Supplemental Figure 9: Mito-Met10 and metformin directly inhibit pyruvate-driven, but not succinate-driven, respiration in permeabilized cells. Supplemental Figure 10: High concentrations of Mito-Met10 induce cellular oxidants in HPNE cells. Supplemental Figure 11: Tissue accumulation of Mito-Met10 in in vivo FC-1242-luc orthotopic mouse model.
Supplementary Mov. 2 from Tumor Cell Invasion Can Be Blocked by Modulators of Collagen Fibril Alignment That Control Assembly of the Extracellular Matrix
Authors: Grossman Moran , Ben-Chetrit Nir , Zhuravlev Alina , Afik Ran , Bassat Elad , Solomonov Inna , Yarden Yosef , Sagi Irit
Published: March 2023

Supplementary Mov. 2 from Tumor Cell Invasion Can Be Blocked by Modulators of Collagen Fibril Alignment That Control Assembly of the Extracellular Matrix
Supplemental dataset 1 from Cancer Differentiating Agent Hexamethylene Bisacetamide Inhibits BET Bromodomain Proteins
Authors: Nilsson Lisa M. , Green Lydia C. , Muralidharan Somsundar Veppil , Demir Dağsu , Welin Martin , Bhadury Joydeep , Logan Derek T. , Walse Björn , Nilsson Jonas A.
Published: March 2023

Microarray data
Supplementary Materials and Methods, Supplementary Figures 1 through 9, and Supplementary Tables 1 through 4 from Early Epigenetic Downregulation of microRNA-192 Expression Promotes Pancreatic Cancer Progression
Authors: Botla Sandeep K. , Savant Soniya , Jandaghi Pouria , Bauer Andrea S. , Mücke Oliver , Moskalev Evgeny A. , Neoptolemos John P. , Costello Eithne , Greenhalf William , Scarpa Aldo , Gaida Matthias M. , Büchler Markus W. , Strobel Oliver , Hackert Thilo , Giese Nathalia A. , Augustin Hellmut G. , Hoheisel Jörg D.
Published: March 2023

Supplementary Materials and Methods, Supplementary Figure 1. Representation of the DNA sequence upstream of the miR-192 gene and location of differentially methylated CpG dimers. Supplementary Figure 2. Assessment of in vitro DNA methylation of the CpG island sequence upstream the miR-192 transcription start site (TSS) by agarose gel electrophoresis after digesting with restriction endonuclease AciI. Supplementary Figure 3. Heatmap showing differentially expressed microRNAs in PDAC compared to normal pancreas tissue. Supplementary Figure 4. Heatmap displaying differentially expressed microRNAs in CP compared to normal pancreas tissue. Supplementary Figure 5. Heatmap showing a three-way comparison of microRNA expression in PDAC, CP and healthy pancreas tissues. Supplementary Figure 6. Result of bisulfite sequencing of the CpGI located 2.3 kb upstream of miR-181c. Supplementary Figure 7. Analysis of the effect of 5-azacytidine treatment on miR-192 expression in cell lines BXPC-3 and PANC-1. Supplementary Figure 8. Receiver Operating Characteristic (ROC) curve displaying the ability of miR-192 expression to discriminate between CP and PDAC samples. Supplementary Figure 9. Correlation of miR-192 expression and tumor stage. Supplementary Table 1. List of analyzed patient samples with information about relevant clinical annotations and the types of analysis that were performed with each sample. Supplementary Table 2. List of all DNA primer sequences used in this study. Supplementary Table 3. Summary of the methylation status of the analyzed CpG islands found upstream of the TSSs of the set of 13 miRNAs that exhibited differential expression of a similar nature in both CP and PDAC and had CpGIs within 10 kb upstream their TSSs. Supplementary Table 4. List of predicted miR-192 targets.
Supplemental Figures from CRM1 Inhibition Promotes Cytotoxicity in Ewing Sarcoma Cells by Repressing EWS-FLI1–Dependent IGF-1 Signaling
Authors: Sun Haibo , Lin De-Chen , Cao Qi , Guo Xiao , Marijon Helene , Zhao Zhiqiang , Gery Sigal , Xu Liang , Yang Henry , Pang Brendan , Lee Victor Kwan Min , Lim Huey Jin , Doan Ngan , Said Jonathan W. , Chu Peiguo , Mayakonda Anand , Thomas Tom , Forscher Charles , Baloglu Erkan , Shacham Sharon , Rajalingam Raja , Koeffler H. Phillip
Published: March 2023

Fig. S1. Expression of CRM1 in EWS cell lines. Fig. S2. Treatment of KPT-330 caused tolerable cytotoxic effect in normal CD34+ cells. Fig. S3.p53 is regulated to drive KPT-330 dependent anti-proliferation effect in wildtype EWS cell lines. Fig. S4. KPT-330 has modest effect on regulation of other fusion proteins. Fig. S5. Combination of KPT-330 and Crizotinib synergistically inhibited cell proliferation in EWS cell lines. Fig. S6. Venn diagram of genes co-downregulated by KPT-330 compared with genes downregulated by EWS-FLI1.
Figure S12 from miR-214 and miR-148b Targeting Inhibits Dissemination of Melanoma and Breast Cancer
Authors: Orso Francesca , Quirico Lorena , Virga Federico , Penna Elisa , Dettori Daniela , Cimino Daniela , Coppo Roberto , Grassi Elena , Elia Angela Rita , Brusa Davide , Deaglio Silvia , Brizzi Maria Felice , Stadler Michael B. , Provero Paolo , Caselle Michele , Taverna Daniela
Published: March 2023

ITGA5 and ALCAM control transendothelial migration in vitro and extravasation in mice
Supplementary Table 4 from Gender-Specific Molecular and Clinical Features Underlie Malignant Pleural Mesothelioma
Authors: De Rienzo Assunta , Archer Michael A. , Yeap Beow Y. , Dao Nhien , Sciaranghella Daniele , Sideris Antonios C. , Zheng Yifan , Holman Alexander G. , Wang Yaoyu E. , Dal Cin Paola S. , Fletcher Jonathan A. , Rubio Renee , Croft Larry , Quackenbush John , Sugarbaker Peter E. , Munir Kiara J. , Battilana Jesse R. , Gustafson Corinne E. , Chirieac Lucian R. , Ching Soo Meng , Wong James , Tay Liang Chung , Rudd Stephen , Hercus Robert , Sugarbaker David J. , Richards William G. , Bueno Raphael
Published: March 2023

List of the 51 canonical pathways significantly enriched (p<0.05) for the mutated genes identify by Ingenuity Pathway Analysis
Figure S1 from miR-214 and miR-148b Targeting Inhibits Dissemination of Melanoma and Breast Cancer
Authors: Orso Francesca , Quirico Lorena , Virga Federico , Penna Elisa , Dettori Daniela , Cimino Daniela , Coppo Roberto , Grassi Elena , Elia Angela Rita , Brusa Davide , Deaglio Silvia , Brizzi Maria Felice , Stadler Michael B. , Provero Paolo , Caselle Michele , Taverna Daniela
Published: March 2023

Analysis of miR-214 and miR-148b sponge efficacy
Supplementary Figure S3 from Oxygen-Enhanced MRI Accurately Identifies, Quantifies, and Maps Tumor Hypoxia in Preclinical Cancer Models
Authors: O'Connor James P.B. , Boult Jessica K.R. , Jamin Yann , Babur Muhammad , Finegan Katherine G. , Williams Kaye J. , Little Ross A. , Jackson Alan , Parker Geoff J.M. , Reynolds Andrew R. , Waterton John C. , Robinson Simon P.
Published: March 2023

R1 changes in Oxy-E and Oxy-R sub-regions
Supplemental Table 3 from Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease
Authors: Murphy Stephen J. , Hart Steven N. , Halling Geoffrey C. , Johnson Sarah H. , Smadbeck James B. , Drucker Travis , Lima Joema Felipe , Rohakhtar Fariborz Rakhshan , Harris Faye R. , Kosari Farhad , Subramanian Subbaya , Petersen Gloria M. , Wiltshire Timothy D. , Kipp Benjamin R. , Truty Mark J. , McWilliams Robert R. , Couch Fergus J. , Vasmatzis George
Published: March 2023

Comparison of current data with published data sets of PDAC.
Supplementary Figure S1 from Oxygen-Enhanced MRI Accurately Identifies, Quantifies, and Maps Tumor Hypoxia in Preclinical Cancer Models
Authors: O'Connor James P.B. , Boult Jessica K.R. , Jamin Yann , Babur Muhammad , Finegan Katherine G. , Williams Kaye J. , Little Ross A. , Jackson Alan , Parker Geoff J.M. , Reynolds Andrew R. , Waterton John C. , Robinson Simon P.
Published: March 2023

Schematic representation of MRI protocols
Supplemental Figure Legeneds from Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease
Authors: Murphy Stephen J. , Hart Steven N. , Halling Geoffrey C. , Johnson Sarah H. , Smadbeck James B. , Drucker Travis , Lima Joema Felipe , Rohakhtar Fariborz Rakhshan , Harris Faye R. , Kosari Farhad , Subramanian Subbaya , Petersen Gloria M. , Wiltshire Timothy D. , Kipp Benjamin R. , Truty Mark J. , McWilliams Robert R. , Couch Fergus J. , Vasmatzis George
Published: March 2023

Supplemental figure legends to accompany supplemental data file
Supplementary Tables 1 through 3 from Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas
Authors: Bouillez Audrey , Rajabi Hasan , Pitroda Sean , Jin Caining , Alam Maroof , Kharbanda Akriti , Tagde Ashujit , Wong Kwok-Kin , Kufe Donald
Published: March 2023

qPCR Primers (S1); Promoter ChIP qPCR Primers (S2); Combination Indices (S3).
Supplementary Figures: Lack of p53 Augments Anti-Tumor Functions in Cytolytic T Cells from Lack of p53 Augments Antitumor Functions in Cytolytic T Cells
Authors: Banerjee Anirban , Thyagarajan Krishnamurthy , Chatterjee Shilpak , Chakraborty Paramita , Kesarwani Pravin , Soloshchenko Myroslawa , Al-Hommrani Mazen , Andrijauskaite Kristina , Moxley Kelly , Janakiraman Harinarayanan , Scheffel Matthew J. , Helke Kristi , Armenson Kent , Palanisamy Viswanathan , Rubinstein Mark P. , Mayer Elizabeth-Garrett , Cole David J. , Paulos Chrystal M. , Voelkel-Johnson Christina , Nishimura Michael I. , Mehrotra Shikhar
Published: March 2023

Details for comparative characterization of phenotype and anti-tumor function between the p53-KO vs. WT T cells are included.
Supplementary Figure 3 from Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas
Authors: Bouillez Audrey , Rajabi Hasan , Pitroda Sean , Jin Caining , Alam Maroof , Kharbanda Akriti , Tagde Ashujit , Wong Kwok-Kin , Kufe Donald
Published: March 2023

Rescue of A549/CRISPR cells with enforced MUC1-C expression.
Supplementary Figure 2 from Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas
Authors: Bouillez Audrey , Rajabi Hasan , Pitroda Sean , Jin Caining , Alam Maroof , Kharbanda Akriti , Tagde Ashujit , Wong Kwok-Kin , Kufe Donald
Published: March 2023

Effects of targeting MUC1-C in non-KRAS mutant NSCLC cells.
Supplementary Figure 1 from Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas
Authors: Bouillez Audrey , Rajabi Hasan , Pitroda Sean , Jin Caining , Alam Maroof , Kharbanda Akriti , Tagde Ashujit , Wong Kwok-Kin , Kufe Donald
Published: March 2023

Silencing MUC1-C suppresses MYC levels.
Supplementary Figure S4 from miR-1298 Inhibits Mutant KRAS-Driven Tumor Growth by Repressing FAK and LAMB3
Authors: Zhou Ying , Dang Jason , Chang Kung-Yen , Yau Edwin , Aza-Blanc Pedro , Moscat Jorge , Rana Tariq M.
Published: March 2023

miR-1298 promotes apotosis in KRASmut NSCLC cell line.
Supplementary Figure S4 from PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling
Authors: Hein Ashley L. , Seshacharyulu Parthasarathy , Rachagani Satyanarayana , Sheinin Yuri M. , Ouellette Michel M. , Ponnusamy Moorthy P. , Mumby Marc C. , Batra Surinder K. , Yan Ying
Published: March 2023

Decrease of PR55Î± expression in pancreatic cancer cells inhibits tumor growth.
Supplementary Figure S2 from PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling
Authors: Hein Ashley L. , Seshacharyulu Parthasarathy , Rachagani Satyanarayana , Sheinin Yuri M. , Ouellette Michel M. , Ponnusamy Moorthy P. , Mumby Marc C. , Batra Surinder K. , Yan Ying
Published: March 2023

Effect of PR55Î± expression on clonogenicity of pancreatic cancer cells
Supplementary Figure S4 from Loss of TGFβ Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance
Authors: Busch Susann , Sims Andrew H. , Stål Olle , Fernö Mårten , Landberg Göran
Published: March 2023

Pharmacological inhibition of TGFβ signaling.
Supplementary Materials and Methods and Supplementary Figures 1 through 5 from Acidosis Acts through HSP90 in a PHD/VHL-Independent Manner to Promote HIF Function and Stem Cell Maintenance in Glioma
Authors: Filatova Alina , Seidel Sascha , Böğürcü Nuray , Gräf Sabine , Garvalov Boyan K. , Acker Till
Published: March 2023

Supplementary Information including: Supplementary Materials and Methods Supplementary References Supplementary Figure S1: Expression of HIF and HIF target genes in cells exposed to varying O2, CO2 and glucose levels. Supplementary Figure S2: Acidosis enhances the CSC phenotype. Supplementary Figure S3: Silencing of HIF1/2 by siRNA. Supplementary Figure S4: HSP90 inactivation by a dominant negative form of HSP90 reduces HIF levels and inhibits tumor growth. Supplementary Figure S5: Loss of HSP90 increases survival and reduces intratumoral HIF levels.
Supplementary Materials and Methods from Hemolytic E. coli Promotes Colonic Tumorigenesis in Females
Authors: Jin Ye , Tang Senwei , Li Weilin , Ng Siew Chien , Chan Michael W.Y. , Sung Joseph J.Y. , Yu Jun
Published: March 2023

Supplementary Materials and Methods
Supplementary Figure S4 from Hemolytic E. coli Promotes Colonic Tumorigenesis in Females
Authors: Jin Ye , Tang Senwei , Li Weilin , Ng Siew Chien , Chan Michael W.Y. , Sung Joseph J.Y. , Yu Jun
Published: March 2023

Mild inflammation and polyp-like outgrowths in the colon of AOM-pretreated mice which were fed with J47, J47Î"hly or PBS. (A) Colon length of wild-type BALB/c mice fed with E. coli or PBS. (B) Scores of colonic inflammation of the mice. (C) Representative images of H&E-stained colonic sections illustrating inflammatory cell infiltrates in the mucosa and loss of goblet cells or crypts (indicated by black arrows). (D) Microscopic examination of the H&E-stained colon tissues revealed that macroscopically observed polyps were colorectal lymphoid aggregates. ns, not statistically significant.
Supplementary Figure S3 from Hemolytic E. coli Promotes Colonic Tumorigenesis in Females
Authors: Jin Ye , Tang Senwei , Li Weilin , Ng Siew Chien , Chan Michael W.Y. , Sung Joseph J.Y. , Yu Jun
Published: March 2023

Requirement of FimH for colonization of hly+ type 1-E. coli in the colon of mice. (A) Colonization and persistence of J47, J47Î"hly and J47Î"fimH in the colon of wild-type BALB/c mice, as revealed by the number of the fed bacteria in stools. The bacteria number was determined by counting colony forming units (CFU). (B) Colonization of J47 and J47Î"hly in colonic mucosa of mice as revealed by percentage of the fed bacteria in total mucosa E. coli. ns, not significantly different; *P < 0.05; **P < 0.01.
Supplementary Methods from AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models
Authors: Weir Hazel M. , Bradbury Robert H. , Lawson Mandy , Rabow Alfred A. , Buttar David , Callis Rowena J. , Curwen Jon O. , de Almeida Camila , Ballard Peter , Hulse Michael , Donald Craig S. , Feron Lyman J.L. , Karoutchi Galith , MacFaul Philip , Moss Thomas , Norman Richard A. , Pearson Stuart E. , Tonge Michael , Davies Gareth , Walker Graeme E. , Wilson Zena , Rowlinson Rachel , Powell Steve , Sadler Claire , Richmond Graham , Ladd Brendon , Pazolli Ermira , Mazzola Anne Marie , D'Cruz Celina , De Savi Chris
Published: March 2023

Methods are given for: the use of SILAC assays to measure the rate of estrogen receptor α peptide degradation over time, the measurement of compound binding affinity of estrogen receptor α ligand binding domain using BIAcore, immunoblotting of estrogen and progesterone receptor proteins, RNA extraction and transcript analysis of estrogen receptor regulated genes, rat uterine model and human breast xenograft model studies, analysis of proteins from tumour fragments and measurement of compound concentration in animal models.
CAN-15-1348R-Supplementary materials and methods from Injury-Driven Stiffening of the Dermis Expedites Skin Carcinoma Progression
Authors: Mittapalli Venugopal R. , Madl Josef , Löffek Stefanie , Kiritsi Dimitra , Kern Johannes S. , Römer Winfried , Nyström Alexander , Bruckner-Tuderman Leena
Published: March 2023

Supplementary Materials and Methods
CAN-15-1348R-Supplementary Figure-S1 from Injury-Driven Stiffening of the Dermis Expedites Skin Carcinoma Progression
Authors: Mittapalli Venugopal R. , Madl Josef , Löffek Stefanie , Kiritsi Dimitra , Kern Johannes S. , Römer Winfried , Nyström Alexander , Bruckner-Tuderman Leena
Published: March 2023

Bar graph showing qPCR quantification
Supplementary Figure S9 from Comprehensive Ex Vivo Transposon Mutagenesis Identifies Genes That Promote Growth Factor Independence and Leukemogenesis
Authors: Guo Yabin , Updegraff Barrett L. , Park Sunho , Durakoglugil Deniz , Cruz Victoria H. , Maddux Sarah , Hwang Tae Hyun , O'Donnell Kathryn A.
Published: March 2023

SB copy number analysis and validation using lentivirus/retrovirus.
Supplementary Figure S1 from Comprehensive Ex Vivo Transposon Mutagenesis Identifies Genes That Promote Growth Factor Independence and Leukemogenesis
Authors: Guo Yabin , Updegraff Barrett L. , Park Sunho , Durakoglugil Deniz , Cruz Victoria H. , Maddux Sarah , Hwang Tae Hyun , O'Donnell Kathryn A.
Published: March 2023

SB mutagenesis drives growth factor-independence and tumorigenesis and analysis of SB insertions in a high-throughput mutagenesis screen.
Supplementary Dataset S1 from Comprehensive Ex Vivo Transposon Mutagenesis Identifies Genes That Promote Growth Factor Independence and Leukemogenesis
Authors: Guo Yabin , Updegraff Barrett L. , Park Sunho , Durakoglugil Deniz , Cruz Victoria H. , Maddux Sarah , Hwang Tae Hyun , O'Donnell Kathryn A.
Published: March 2023

All CIS genes identified in the comprehensive Ba/F3 mutagenesis screen.
Supplementary Figure 7 from Antagonizing Integrin β3 Increases Immunosuppression in Cancer
Authors: Su Xinming , Esser Alison K. , Amend Sarah R. , Xiang Jingyu , Xu Yalin , Ross Michael H. , Fox Gregory C. , Kobayashi Takayuki , Steri Veronica , Roomp Kirsten , Fontana Francesca , Hurchla Michelle A. , Knolhoff Brett L. , Meyer Melissa A. , Morgan Elizabeth A. , Tomasson Julia C. , Novack Joshua S. , Zou Wei , Faccio Roberta , Novack Deborah V. , Robinson Stephen D. , Teitelbaum Steven L. , DeNardo David G. , Schneider Jochen G. , Weilbaecher Katherine N.
Published: March 2023

Integrin beta3 regulates STAT6 signaling
Supplementary Table S1 from MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development
Authors: Eso Yuji , Takai Atsushi , Matsumoto Tomonori , Inuzuka Tadashi , Horie Takahiro , Ono Koh , Uemoto Shinji , Lee Kyeryoung , Edelmann Winfried , Chiba Tsutomu , Marusawa Hiroyuki
Published: March 2023

Primers for quantitative real-time RT-PCR analysis
Supplementary Figure 4 from Antagonizing Integrin β3 Increases Immunosuppression in Cancer
Authors: Su Xinming , Esser Alison K. , Amend Sarah R. , Xiang Jingyu , Xu Yalin , Ross Michael H. , Fox Gregory C. , Kobayashi Takayuki , Steri Veronica , Roomp Kirsten , Fontana Francesca , Hurchla Michelle A. , Knolhoff Brett L. , Meyer Melissa A. , Morgan Elizabeth A. , Tomasson Julia C. , Novack Joshua S. , Zou Wei , Faccio Roberta , Novack Deborah V. , Robinson Stephen D. , Teitelbaum Steven L. , DeNardo David G. , Schneider Jochen G. , Weilbaecher Katherine N.
Published: March 2023

STAT1 and STAT6 downstream gene expression
Supplementary Figure Legends from MSH2 Dysregulation Is Triggered by Proinflammatory Cytokine Stimulation and Is Associated with Liver Cancer Development
Authors: Eso Yuji , Takai Atsushi , Matsumoto Tomonori , Inuzuka Tadashi , Horie Takahiro , Ono Koh , Uemoto Shinji , Lee Kyeryoung , Edelmann Winfried , Chiba Tsutomu , Marusawa Hiroyuki
Published: March 2023

Supplementary Figure Legends
Supplementary Figure 3 from Antagonizing Integrin β3 Increases Immunosuppression in Cancer
Authors: Su Xinming , Esser Alison K. , Amend Sarah R. , Xiang Jingyu , Xu Yalin , Ross Michael H. , Fox Gregory C. , Kobayashi Takayuki , Steri Veronica , Roomp Kirsten , Fontana Francesca , Hurchla Michelle A. , Knolhoff Brett L. , Meyer Melissa A. , Morgan Elizabeth A. , Tomasson Julia C. , Novack Joshua S. , Zou Wei , Faccio Roberta , Novack Deborah V. , Robinson Stephen D. , Teitelbaum Steven L. , DeNardo David G. , Schneider Jochen G. , Weilbaecher Katherine N.
Published: March 2023

Integrin beta3 antagonist treatment on early stage breast tumor growth
Supplementary Figure 5 from Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling
Authors: Peng Dongjun , Tanikawa Takashi , Li Wei , Zhao Lili , Vatan Linda , Szeliga Wojciech , Wan Shanshan , Wei Shuang , Wang Yin , Liu Yan , Staroslawska Elzbieta , Szubstarski Franciszek , Rolinski Jacek , Grywalska Ewelina , Stanisławek Andrzej , Polkowski Wojciech , Kurylcio Andrzej , Kleer Celina , Chang Alfred E. , Wicha Max , Sabel Michael , Zou Weiping , Kryczek Ilona
Published: March 2023

Correlations between CD33, ALDH1A1 and IL6 transcripts in patients with breast cancer
Supplementary Figure 3 from Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling
Authors: Peng Dongjun , Tanikawa Takashi , Li Wei , Zhao Lili , Vatan Linda , Szeliga Wojciech , Wan Shanshan , Wei Shuang , Wang Yin , Liu Yan , Staroslawska Elzbieta , Szubstarski Franciszek , Rolinski Jacek , Grywalska Ewelina , Stanisławek Andrzej , Polkowski Wojciech , Kurylcio Andrzej , Kleer Celina , Chang Alfred E. , Wicha Max , Sabel Michael , Zou Weiping , Kryczek Ilona
Published: March 2023

Relationship between MDSCs and breast cancer stemness
Supplementary Figure Legends from Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis
Authors: Xing Cheng , Lu Xing-Xing , Guo Peng-Da , Shen Tong , Zhang Shen , He Xiao-Shun , Gan Wen-Juan , Li Xiu-Ming , Wang Jing-Ru , Zhao Yuan-Yuan , Wu Hua , Li Jian-Ming
Published: March 2023

Legends for Supplementary Figures S1-S8.
Supplementary Figure 2 from Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling
Authors: Peng Dongjun , Tanikawa Takashi , Li Wei , Zhao Lili , Vatan Linda , Szeliga Wojciech , Wan Shanshan , Wei Shuang , Wang Yin , Liu Yan , Staroslawska Elzbieta , Szubstarski Franciszek , Rolinski Jacek , Grywalska Ewelina , Stanisławek Andrzej , Polkowski Wojciech , Kurylcio Andrzej , Kleer Celina , Chang Alfred E. , Wicha Max , Sabel Michael , Zou Weiping , Kryczek Ilona
Published: March 2023

MDSCs in breast cancer tissues
Supplementary Table 2 from An Anti-EGFR IgA That Displays Improved Pharmacokinetics and Myeloid Effector Cell Engagement In Vivo
Authors: Lohse Stefan , Meyer Saskia , Meulenbroek Laura A.P.M. , Jansen J.H. Marco , Nederend Maaike , Kretschmer Anna , Klausz Katja , Möginger Uwe , Derer Stefanie , Rösner Thies , Kellner Christian , Schewe Denis , Sondermann Peter , Tiwari Sanjay , Kolarich Daniel , Peipp Matthias , Leusen Jeanette H.W. , Valerius Thomas
Published: March 2023

N-glycan structures of 225-IgA2-wt and 225-IgA2.0 identified by PGC-LC ESI MS/MS.
Supplemental Figure 6 from In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments
Authors: Morris Zachary S. , Guy Emily I. , Francis David M. , Gressett Monica M. , Werner Lauryn R. , Carmichael Lakeesha L. , Yang Richard K. , Armstrong Eric A. , Huang Shyhmin , Navid Fariba , Gillies Stephen D. , Korman Alan , Hank Jacquelyn A. , Rakhmilevich Alexander L. , Harari Paul M. , Sondel Paul M.
Published: March 2023

The time-sensitivity of combined radiation and hu14.18-IL2 is not observed with radiation and hu14.18K322A and radiation induces a dose-dependent increase in Fas/CD95 expression.
Supplemental Figure 3 from In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments
Authors: Morris Zachary S. , Guy Emily I. , Francis David M. , Gressett Monica M. , Werner Lauryn R. , Carmichael Lakeesha L. , Yang Richard K. , Armstrong Eric A. , Huang Shyhmin , Navid Fariba , Gillies Stephen D. , Korman Alan , Hank Jacquelyn A. , Rakhmilevich Alexander L. , Harari Paul M. , Sondel Paul M.
Published: March 2023

SCC1-C cells are not sensitized to radiation by cetuximab in vitro and remain susceptible to cetuximab-mediated ADCC.
Supplementary Figure S9 from Chemotherapy-Induced miRNA-29c/Catenin-δ Signaling Suppresses Metastasis in Gastric Cancer
Authors: Wang Yuxuan , Liu Changzheng , Luo Min , Zhang Zhengyi , Gong Jianan , Li Jingjing , You Lei , Dong Lei , Su Rui , Lin Haishuang , Ma Yanni , Wang Fang , Wang Yi , Chen Jie , Zhang Junwu , Jia Hongyan , Kong Yan , Yu Jia
Published: March 2023

Supplementary Figure S9. E-cadherin expression is determined in GC cells with drugs treatment.
Supplementary Figure S2 from Chemotherapy-Induced miRNA-29c/Catenin-δ Signaling Suppresses Metastasis in Gastric Cancer
Authors: Wang Yuxuan , Liu Changzheng , Luo Min , Zhang Zhengyi , Gong Jianan , Li Jingjing , You Lei , Dong Lei , Su Rui , Lin Haishuang , Ma Yanni , Wang Fang , Wang Yi , Chen Jie , Zhang Junwu , Jia Hongyan , Kong Yan , Yu Jia
Published: March 2023

Supplementary Figure S2. Correlations between miR-29s levels and histological grade of GCs.
Supplemental Materials and Methods from p28-Mediated Activation of p53 in G2–M Phase of the Cell Cycle Enhances the Efficacy of DNA Damaging and Antimitotic Chemotherapy
Authors: Yamada Tohru , Das Gupta Tapas K. , Beattie Craig W.
Published: March 2023

Western Analysis and Pull-down assay data.
Supplementary Table S4 from Transcriptome Analysis of Recurrently Deregulated Genes across Multiple Cancers Identifies New Pan-Cancer Biomarkers
Authors: Kaczkowski Bogumil , Tanaka Yuji , Kawaji Hideya , Sandelin Albin , Andersson Robin , Itoh Masayoshi , Lassmann Timo , Hayashizaki Yoshihide , Carninci Piero , Forrest Alistair R.R.
Published: March 2023

The list of genes differentially expressed in TCGAs primary tumors vs. normal tissues.
Supplementary Materials and Methods and Supplementary Figure Legends from miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer
Authors: Adams Brian D. , Wali Vikram B. , Cheng Christopher J. , Inukai Sachi , Booth Carmen J. , Agarwal Seema , Rimm David L. , Győrffy Balázs , Santarpia Libero , Pusztai Lajos , Saltzman W. Mark , Slack Frank J.
Published: March 2023

Supplementary Materials and Methods and Supplementary Figure Legends
Fig.S7 from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer
Authors: Quemener Cathy , Baud Jessica , Boyé Kevin , Dubrac Alexandre , Billottet Clotilde , Soulet Fabienne , Darlot Florence , Dumartin Laurent , Sire Marie , Grepin Renaud , Daubon Thomas , Rayne Fabienne , Wodrich Harald , Couvelard Anne , Pineau Raphael , Schilling Martin , Castronovo Vincent , Sue Shih-Che , Clarke Kim , Lomri Abderrahim , Khatib Abdel-Majid , Hagedorn Martin , Prats Hervé , Bikfalvi Andreas
Published: March 2023

Characterization of PECAM-1 expression in pancreatic tumours
Supplementary Table S3 from Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer
Authors: Ando Mizuo , Kawazu Masahito , Ueno Toshihide , Koinuma Daizo , Ando Koji , Koya Junji , Kataoka Keisuke , Yasuda Takahiko , Yamaguchi Hiroyuki , Fukumura Kazutaka , Yamato Azusa , Soda Manabu , Sai Eirin , Yamashita Yoshihiro , Asakage Takahiro , Miyazaki Yasushi , Kurokawa Mineo , Miyazono Kohei , Nimer Stephen D. , Yamasoba Tatsuya , Mano Hiroyuki
Published: March 2023

Genes specifically induced by wild-type ELF4 in T3M-1 Cl-10 cells
Fig.S1 from Dual Roles for CXCL4 Chemokines and CXCR3 in Angiogenesis and Invasion of Pancreatic Cancer
Authors: Quemener Cathy , Baud Jessica , Boyé Kevin , Dubrac Alexandre , Billottet Clotilde , Soulet Fabienne , Darlot Florence , Dumartin Laurent , Sire Marie , Grepin Renaud , Daubon Thomas , Rayne Fabienne , Wodrich Harald , Couvelard Anne , Pineau Raphael , Schilling Martin , Castronovo Vincent , Sue Shih-Che , Clarke Kim , Lomri Abderrahim , Khatib Abdel-Majid , Hagedorn Martin , Prats Hervé , Bikfalvi Andreas
Published: March 2023

Expression Analysis of CXCL4L1 in human pancreatic tissue
Supplementary Table S1 from Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer
Authors: Ando Mizuo , Kawazu Masahito , Ueno Toshihide , Koinuma Daizo , Ando Koji , Koya Junji , Kataoka Keisuke , Yasuda Takahiko , Yamaguchi Hiroyuki , Fukumura Kazutaka , Yamato Azusa , Soda Manabu , Sai Eirin , Yamashita Yoshihiro , Asakage Takahiro , Miyazaki Yasushi , Kurokawa Mineo , Miyazono Kohei , Nimer Stephen D. , Yamasoba Tatsuya , Mano Hiroyuki
Published: March 2023

Caspase activities in T3M-1 Cl-10 cells infected with recombinant retroviruses for the indicated proteins.
Supplementary Movie 4 from Metabolic Stress-Induced Phosphorylation of KAP1 Ser473 Blocks Mitochondrial Fusion in Breast Cancer Cells
Authors: Cheng Chun-Ting , Kuo Ching-Ying , Ouyang Ching , Li Chien-Feng , Chung Yiyin , Chan David C. , Kung Hsing-Jien , Ann David K.
Published: March 2023

Movie 4. Time-lapse imaging of MDA-MB-231/shKAP1/S473D-KAP1 cells in glucose-depleted medium.
Supplementary Figure S7 from Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer
Authors: Ando Mizuo , Kawazu Masahito , Ueno Toshihide , Koinuma Daizo , Ando Koji , Koya Junji , Kataoka Keisuke , Yasuda Takahiko , Yamaguchi Hiroyuki , Fukumura Kazutaka , Yamato Azusa , Soda Manabu , Sai Eirin , Yamashita Yoshihiro , Asakage Takahiro , Miyazaki Yasushi , Kurokawa Mineo , Miyazono Kohei , Nimer Stephen D. , Yamasoba Tatsuya , Mano Hiroyuki
Published: March 2023

Cell cycle analysis of T3M-1 Cl-10 cells expressing various proteins
Supplementary Tables S1-S3 from STAT3/IRF1 Pathway Activation Sensitizes Cervical Cancer Cells to Chemotherapeutic Drugs
Authors: Walch-Rückheim Barbara , Pahne-Zeppenfeld Jennifer , Fischbach Jil , Wickenhauser Claudia , Horn Lars Christian , Tharun Lars , Büttner Reinhard , Mallmann Peter , Stern Peter , Kim Yoo-Jin , Bohle Rainer Maria , Rübe Christian , Ströder Russalina , Juhasz-Böss Ingolf , Solomayer Erich-Franz , Smola Sigrun
Published: March 2023

Pre- and Post-therapeutically staged tumors according to the International Federation of Gynecology and Obstetrics or TNM categories (S1); List of used antibodies (S2); Primers for amplification of cDNAs of IRF1 and IRF2 (S3).
Supplementary Figure S14 from Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer
Authors: Ando Mizuo , Kawazu Masahito , Ueno Toshihide , Koinuma Daizo , Ando Koji , Koya Junji , Kataoka Keisuke , Yasuda Takahiko , Yamaguchi Hiroyuki , Fukumura Kazutaka , Yamato Azusa , Soda Manabu , Sai Eirin , Yamashita Yoshihiro , Asakage Takahiro , Miyazaki Yasushi , Kurokawa Mineo , Miyazono Kohei , Nimer Stephen D. , Yamasoba Tatsuya , Mano Hiroyuki
Published: March 2023

ELF4-mediated induction of DLX3 and HRK mRNA in various cancer cell lines
Supplementary Figure S8 from STAT3/IRF1 Pathway Activation Sensitizes Cervical Cancer Cells to Chemotherapeutic Drugs
Authors: Walch-Rückheim Barbara , Pahne-Zeppenfeld Jennifer , Fischbach Jil , Wickenhauser Claudia , Horn Lars Christian , Tharun Lars , Büttner Reinhard , Mallmann Peter , Stern Peter , Kim Yoo-Jin , Bohle Rainer Maria , Rübe Christian , Ströder Russalina , Juhasz-Böss Ingolf , Solomayer Erich-Franz , Smola Sigrun
Published: March 2023

HeLa cells were transfected with 10 pmol/1.5 x 105 cells of human IRF1-specific siRNA (#8) or mock siRNA.
Supplementary Figure S12 from Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer
Authors: Ando Mizuo , Kawazu Masahito , Ueno Toshihide , Koinuma Daizo , Ando Koji , Koya Junji , Kataoka Keisuke , Yasuda Takahiko , Yamaguchi Hiroyuki , Fukumura Kazutaka , Yamato Azusa , Soda Manabu , Sai Eirin , Yamashita Yoshihiro , Asakage Takahiro , Miyazaki Yasushi , Kurokawa Mineo , Miyazono Kohei , Nimer Stephen D. , Yamasoba Tatsuya , Mano Hiroyuki
Published: March 2023

ChIP-seq analysis on DLX3 and HRK loci
Supplementary Figure S6 from STAT3/IRF1 Pathway Activation Sensitizes Cervical Cancer Cells to Chemotherapeutic Drugs
Authors: Walch-Rückheim Barbara , Pahne-Zeppenfeld Jennifer , Fischbach Jil , Wickenhauser Claudia , Horn Lars Christian , Tharun Lars , Büttner Reinhard , Mallmann Peter , Stern Peter , Kim Yoo-Jin , Bohle Rainer Maria , Rübe Christian , Ströder Russalina , Juhasz-Böss Ingolf , Solomayer Erich-Franz , Smola Sigrun
Published: March 2023

IRF1 is not induced by OSM or IL-6/sgp80 stimulation in NECK.
Supplementary Figure S11 from Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer
Authors: Ando Mizuo , Kawazu Masahito , Ueno Toshihide , Koinuma Daizo , Ando Koji , Koya Junji , Kataoka Keisuke , Yasuda Takahiko , Yamaguchi Hiroyuki , Fukumura Kazutaka , Yamato Azusa , Soda Manabu , Sai Eirin , Yamashita Yoshihiro , Asakage Takahiro , Miyazaki Yasushi , Kurokawa Mineo , Miyazono Kohei , Nimer Stephen D. , Yamasoba Tatsuya , Mano Hiroyuki
Published: March 2023

Validation of shRNAs targeted to DLX3 or HRK
Supplementary Figure S10 from Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer
Authors: Ando Mizuo , Kawazu Masahito , Ueno Toshihide , Koinuma Daizo , Ando Koji , Koya Junji , Kataoka Keisuke , Yasuda Takahiko , Yamaguchi Hiroyuki , Fukumura Kazutaka , Yamato Azusa , Soda Manabu , Sai Eirin , Yamashita Yoshihiro , Asakage Takahiro , Miyazaki Yasushi , Kurokawa Mineo , Miyazono Kohei , Nimer Stephen D. , Yamasoba Tatsuya , Mano Hiroyuki
Published: March 2023

Confirmation of ChIP-seq data for ELF4 binding sites by PCR analysis.
Supplementary Figure S2 from STAT3/IRF1 Pathway Activation Sensitizes Cervical Cancer Cells to Chemotherapeutic Drugs
Authors: Walch-Rückheim Barbara , Pahne-Zeppenfeld Jennifer , Fischbach Jil , Wickenhauser Claudia , Horn Lars Christian , Tharun Lars , Büttner Reinhard , Mallmann Peter , Stern Peter , Kim Yoo-Jin , Bohle Rainer Maria , Rübe Christian , Ströder Russalina , Juhasz-Böss Ingolf , Solomayer Erich-Franz , Smola Sigrun
Published: March 2023

Low constitutive STAT3 activation in cervical cancer cell lines but not in primary cervical carcinoma cells or exocervical keratinocytes after prolonged exposure of Western blot analysis.
Supplementary Figure S1 from STAT3/IRF1 Pathway Activation Sensitizes Cervical Cancer Cells to Chemotherapeutic Drugs
Authors: Walch-Rückheim Barbara , Pahne-Zeppenfeld Jennifer , Fischbach Jil , Wickenhauser Claudia , Horn Lars Christian , Tharun Lars , Büttner Reinhard , Mallmann Peter , Stern Peter , Kim Yoo-Jin , Bohle Rainer Maria , Rübe Christian , Ströder Russalina , Juhasz-Böss Ingolf , Solomayer Erich-Franz , Smola Sigrun
Published: March 2023

79 human FFPE SCC were stained with anti-pTyr705-STAT3 Ab.
Supplementary Table S4 from HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc
Authors: Li Yinghui , Wang Zhen , Shi Hui , Li Hang , Li Leilei , Fang Runping , Cai Xiaoli , Liu Bowen , Zhang Xiaodong , Ye Lihong
Published: March 2023

The common target genes of HBXIP and c-Myc.
Supplementary Materials and Methods, Supplementary Figures 1 through 8, and Supplementary Tables 1 through 6 from Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis
Authors: Marusiak Anna A. , Stephenson Natalie L. , Baik Hayeon , Trotter Eleanor W. , Li Yaoyong , Blyth Karen , Mason Susan , Chapman Phil , Puto Lorena A. , Read Jon A. , Brassington Claire , Pollard Hannah K. , Phillips Chris , Green Isabelle , Overman Ross , Collier Matthew , Testoni Ewelina , Miller Crispin J. , Hunter Tony , Sansom Owen J. , Brognard John
Published: March 2023

Supplementary methods. Figure S1. (related to Fig. 1A-F) Analysis of mutations of MLK4 and MLK1 present in CRC cells. Figure S2 (related to Fig. 2 and 3) Structural analysis of MLK4 mutants. Figure S3 (related to Fig. 2 and 3) Structural analysis of the effects of movements in the glycine rich motif. Figure S4 (related to Fig. 2 and 3) Structural changes within the C-spine and R-spine of MLK4 following loss-of-function mutations. Figure S5 (related to Fig. 4) Reintroduction of MLK4-WT decreases cell viability in LoVo cell line. Figure S6 (related to Fig. 4 and 6) Expression of MLK4 LOF mutants in CRC cells shows no phenotypic effects. Figure S7 (related to Fig. 4 and 6) Expression of MLK4-WT mutants in HCT116 cells shows no phenotypic effects. Figure S8 (related to Fig. 6) Associations between colon cancer patients with MLK4 mutations and expression levels of Cdk inhibitors. Table S1 (related to Fig. 1E) Characteristics of HCT15 and HT115 cell lines. Table S2 (related to Fig. 6A) Differential expression of genes in HCT15 reconstituted with MLK4-WT. Table S3 (related to Fig. 6A) Differential expression of genes in HT115 reconstituted with MLK4-WT. Table S4 (related to Fig. S7F) Differential expression of genes in HCT15 reconstituted with MLK4-Y330H. Table S5 (related to Fig. S7G) Differential expression of genes in HT115 reconstituted with MLK4-E314K. Table S6 (related to Fig. 1F) Crystal and refinement data.
Supplementary method figure from STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment
Authors: Koyama Shohei , Akbay Esra A. , Li Yvonne Y. , Aref Amir R. , Skoulidis Ferdinandos , Herter-Sprie Grit S. , Buczkowski Kevin A. , Liu Yan , Awad Mark M. , Denning Warren L. , Diao Lixia , Wang Jing , Parra-Cuentas Edwin R. , Wistuba Ignacio I. , Soucheray Margaret , Thai Tran , Asahina Hajime , Kitajima Shunsuke , Altabef Abigail , Cavanaugh Jillian D. , Rhee Kevin , Gao Peng , Zhang Haikuo , Fecci Peter E. , Shimamura Takeshi , Hellmann Matthew D. , Heymach John V. , Hodi F. Stephen , Freeman Gordon J. , Barbie David A. , Dranoff Glenn , Hammerman Peter S. , Wong Kwok-Kin
Published: March 2023

This file contains flow cytometry gating strategy used for the analysis of mouse tumors and surface markers for the immune cells described in the manuscript.
Supplementary Figure S2 from HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc
Authors: Li Yinghui , Wang Zhen , Shi Hui , Li Hang , Li Leilei , Fang Runping , Cai Xiaoli , Liu Bowen , Zhang Xiaodong , Ye Lihong
Published: March 2023

HBXIP is required for the up-regulation of Cyclin A, eIF4E and LDHA.
Supplementary figure legends from STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment
Authors: Koyama Shohei , Akbay Esra A. , Li Yvonne Y. , Aref Amir R. , Skoulidis Ferdinandos , Herter-Sprie Grit S. , Buczkowski Kevin A. , Liu Yan , Awad Mark M. , Denning Warren L. , Diao Lixia , Wang Jing , Parra-Cuentas Edwin R. , Wistuba Ignacio I. , Soucheray Margaret , Thai Tran , Asahina Hajime , Kitajima Shunsuke , Altabef Abigail , Cavanaugh Jillian D. , Rhee Kevin , Gao Peng , Zhang Haikuo , Fecci Peter E. , Shimamura Takeshi , Hellmann Matthew D. , Heymach John V. , Hodi F. Stephen , Freeman Gordon J. , Barbie David A. , Dranoff Glenn , Hammerman Peter S. , Wong Kwok-Kin
Published: March 2023

This file contains information regarding the figure legends and detailed description for the supplementary figures.
Supplementary Figure Legends from HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc
Authors: Li Yinghui , Wang Zhen , Shi Hui , Li Hang , Li Leilei , Fang Runping , Cai Xiaoli , Liu Bowen , Zhang Xiaodong , Ye Lihong
Published: March 2023

Legends for Supplementary Figures S1-S6.
Supplementary Figure S6 from Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-κB Signaling Pathway
Authors: Ohtsu Naoki , Nakatani Yuka , Yamashita Daisuke , Ohue Shiro , Ohnishi Takanori , Kondo Toru
Published: March 2023

Eva1 expression level affects the NF-κB activity that is indispensable for the proliferation of NSCL61.
Supplementary Figure S5 from Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-κB Signaling Pathway
Authors: Ohtsu Naoki , Nakatani Yuka , Yamashita Daisuke , Ohue Shiro , Ohnishi Takanori , Kondo Toru
Published: March 2023

Microarray analysis of gene expression in NSCL61 and eva1sh-expressing NSCL61 cells.
Supplementary Figure S4 from Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-κB Signaling Pathway
Authors: Ohtsu Naoki , Nakatani Yuka , Yamashita Daisuke , Ohue Shiro , Ohnishi Takanori , Kondo Toru
Published: March 2023

Self-renewal activity of eva1- and eva1sh-expressing hGICs.