bluuebunny/crossref_metadata_2025 huggingface dataset:
THE RELATIONSHIP BETWEEN FAMILY COMMUNICATION PATTERN AND YOUTH SELFCONCEPT IN RURAL MALAYSIA
Authors: Mohd Nasir Mohd Azrin , Tahrir Adli Ansarul Haq
Published: September 2023

This study aimed to investigate the relationship between family communication patterns and self-concept among youth in rural areas. The sample consisted of 315 participants (150 boys and 165 girls), selected using a simple random sampling technique. The Revised Family Communication Pattern (RFCP) Survey, which has two dimensions - conversational orientation and conformity orientation, was used to measure the relationship between the variables. The Tennessee Self-Concept Scale, which has six dimensions - social, moral, family, ethical, physical, and personal - was also used. Demographic factors such as gender, race, education, and religious affiliation were measured. The results showed significant relationships between family communication patterns for conversational orientation and physical, ethical, personal, family, and social self-concept, with the exception of moral self-concept, which showed medium levels. Additionally, there were significant relationships between conformity orientation and moral and ethical self-concept, and weak relationships with physical, family, and social self-concept. These findings reaffirm the importance of family communication patterns in shaping the selfconcept of youth in rural areas.
PENDERAAN EKONOMI MANGSA KEGANASAN RUMAH TANGGA: PERSPEKTIF PENGAMAL
Authors: Abd Manaf Abdul Razak , Othman Siti Zubaidah , Mat Saad Zarina , Mohd Noor Annuar Aswan , Awang Faridah
Published: September 2023

Keganasan rumah tangga merupakan satu fenomena global dalam masyarakat sejak sekian lama yang begitu kompleks dan perlu ditangani dengan sebaiknya. Artikel ini cuba membincangkan salah satu hasil dapatan daripada keseluruhan kajian yang dilaksanakan bagi meneliti isu penderaan ekonomi dan kesejahteraan kewangan mangsa keganasan rumah tangga. Ia cuba meneroka isu ekonomi yang dihadapi oleh wanita yang menjadi mangsa keganasan rumah tangga daripada perspektif pengamal yang mengendalikan keskes sebegini. Data kajian kualitatif ini diperoleh semasa temubual dan perbincangan kumpulan berfokus (FGD) dilaksanakan dengan menggunakan analisis tematik. Seramai lima belas orang kakitangan atau pengamal di Jabatan Kebajikan Masyarakat telah diminta untuk berkongsi pengalaman mereka berkenaan isu pengendalian kes mangsa keganasan rumah tangga serta konflik kewangan dan kesejahteraan ekonomi wanita yang menjadi mangsa penderaan. Hasil kajian mendapati bahawa isu-isu penderaan ekonomi dan kewangan tertumpu kepada isu pekerjaan dan sumber pendapatan serta kebergantungan si pelaku dan mangsa, isu gaya hidup negatif pelaku dan kawalan pelaku kepada sumber kewangan yang dijana oleh mangsa.    ABSTRACT Domestic violence has been a global phenomenon in society for ages. It is so complex and needs to be dealt with accordingly. This paper tries to discuss one of the findings from the overall, bigger study that was carried out to examine the issue of economic abuse and the financial well-being of victims of domestic violence. It attempts to explore the issues faced by victims of domestic violence from the perspective of practitioners who handle such cases. The data of this qualitative study was obtained during interviews and focus group discussions (FGD) conducted using thematic analysis. A total of fifteen staff members or practitioners in the Department of Social Welfare were asked to share their experiences in handling cases of domestic violence victims as well as financial conflicts and the economic well-being of abuse victims. The results of the study found that the issues of economic and financial abuse are focused on the issue of employment and source of income as well as the dependency of the perpetrator and the victim, the issue of the perpetrator’s negative lifestyle and the perpetrator’s control over the financial resources generated by the victim.
Synthesis of Self-Efficacy of Academic Resilience Capacity (SEARC) as the Implication of Self-Efficacy Contribution to Student Academic
Authors: Fatia Azhariah , Alfaiz Alfaiz , Yuzarion Yuzarion , Julius Andre , Hidayat Rafiola Ryan , Singgih Sendayu Fendahapsari , Valdez Anabelie V. , Juliawati Dosi
Published: September 2023

Many students in the educational process need more resilience. This research aims to determine the academic resilience of students' self-efficacy aspects, such as mastery experience, vicarious experience, social persuasion, and emotional state. It also aims to synthesize a framework for modifying students’ academic behavior, namely Self-Efficacy of Academic Resilience Capacity (SEARC). A quantitative approach with regression and literature analyses was used to develop a synthesis framework based on the field findings. The random sampling method was used to collect data on students' self-efficacy. The instrument used in this research was the Academic Self-Efficacy Scale (ASES) developed by Alfaiz with a 0.898 reliability. The collected data were analyzed descriptively and regression analysis was used to test the hypothesis. The results showed that mastery experience, vicarious experience, and emotional state significantly increase students’ resilience but social persuasion is insignificant when viewed partially. It implies that self-efficacy ability contributes to academic resilience.
Development of Website-Based Worksheets on Flat 3D Shapes Topic
Authors: Erita Selvia , Nelda Hikma , Ningsih Febria
Published: September 2023

The development of website-based worksheets represents an innovation to enhance the quality of education during the Covid-19 pandemic. The aim of this study is to outline the process of creating and assessing the feasibility of website-based worksheets on the topic of flat 3D shapes. The ADDIE model, consisting of five phases: analysis, design, development, implementation, and evaluation, was used in this research. The instruments utilized included media and content validation questionnaires, teacher and student response questionnaires, and tests. The findings indicate that the website-based worksheets on flat 3D shapes fulfilled the criteria for validity, practicality, and effectiveness. The average validity index of the website-based worksheets was in the valid category, while the average of teacher and student responses to the worksheets was in the practical category. Furthermore, based on the average student learning outcomes, the website-based worksheets were found to be effective. As such, these worksheets can be adapted for use with other materials by adjusting the design and content to suit the needs and characteristics of students, leading to more effective and efficient learning.
Implementation of the Consciousness-Raising (C-R) Method in Improving EFL Students’ Writing Skills
Authors: Suhaimi Suhaimi , Musdizal Musdizal
Published: September 2023

The purpose of this study was to determine the extent to which the Consciousness-Raising (C-R) method improves students' writing skills and to identify the factors that influence the improvement process. The study was conducted with third-semester students in the English Department, consisting of 16 students. The research design was Classroom Action Research (CAR) and was carried out in three cycles over a period of 12 weeks, with four meetings including one test in each cycle. The cycles comprised of planning, action, observation, and reflection. Qualitative data was obtained through observation, field notes, and interviews, while quantitative data was obtained from students' writing tests. The results of this study showed improvement in the students' writing skills, as demonstrated by the teaching and learning activities throughout each cycle and the increasing scores of the students' writing tests, which went from 65.45 in cycle 1 to 77.63 in cycle 2 and 88.22 in cycle 3. The decrease in errors in each test cycle also supported this improvement. The observation and field notes indicated that the C-R method increased students' attention and awareness, resulting in more focus and engagement in the learning process. The factors that influenced the improvement of students' writing skills were motivation, the role of the instructor, classroom environment, materials, and media. The C-R method was found to be effective in improving students' writing skills and resolving writing problems. The researcher therefore recommends the use of this method, taking into consideration the supporting factors.
Mechanism and Role of Tumor Microenvironment in the Initiation and Progression of Bladder Cancer
Authors: Cui Na , Shi Yajun , Ding Yi , Wang Yanhua
Published: September 2023

Tumor microenvironment (TME) is a huge network, composed by tumor cells, tumor associated stromal cells, immune cells, cytokines and chemokines secreted by these cells, in which various cells communicate with each other. Bladder cancer is characterized of tendency of relapse, progression, metastasis because of the role of TME. With the application and development of new technologies recently, such as tumor bulk RNA-sequencing and single-cell transcriptome sequencing, the composition of TME for bladder cancer is increasingly clear and the complex cell-to-cell communication network is fully duged, which provides a new vision for the therapy of bladder cancer. This paper reviewed and further analysed the research hotspots of cellular components and extracellular matrix components of bladder cancer on the basis of the latest research progress.
Right Hemifacial Paralysis in a 6-Year-Old Boy: An Overlooked Case Report of Bell’s Palsy in Children
Authors: Sofian Jessica , Usman Johnwan , HSA Rachmanto , Athira Ghaisania , Thedra Nathania
Published: September 2023

This study focuses on a case of Bell's Palsy in a 6-year-old boy. Bell's Palsy is the most common type of facial nerve paralysis in children. The causes can be either congenital factors (traumatic malformations, symptomatic, non-syndromic, or hereditary conditions) or acquired factors (infections, inflammations, neoplastic, or traumatic factors). Bell's Palsy is commonly caused by viral infections, especially the herpes simplex virus. In this case, a child experienced rapid-onset right hemifacial paralysis, and he had no history of trauma or other systemic symptoms. A diagnosis of Bell's Palsy was made, and the child received treatment with corticosteroids and a rehabilitation program. The results of this study indicate that treatment with methylprednisolone for 3 days and a rehabilitation program involving relaxation exercises and massages to reduce muscle stiffness yielded a good response. Proper clinical observation and evaluation are crucial in diagnosing Bell's Palsy in children. A multidisciplinary approach through collaboration between pediatricians and physiotherapists plays a significant role in managing such cases. Good follow-up is necessary to reduce the risk of prolonged facial nerve paralysis in the future.
Основні підходи щодо вибору логічної структури бази даних для автоматизованої інформаційної системи органу військового управління
Authors: Крайнов Валерій , Лаврінчук Олександр , Грозовський Роман
Published: September 2023

Існуючі на даний момент вимоги до якості прийняття рішень у різних сферах військового управління призвели до необхідності розробки та використання спеціалізованого програмного забезпечення, яке дозволило б здійсню-вати накопичення, зберігання та аналіз доступних об’ємів інформації, які забезпечують вирішення завдань, що стоять перед органом військового управління. Однак існуючі автоматизовані інформаційні системи органу військового управління, що орієнтовані на конкретні програми, не відповідають вимогам офіцерів-користувачів, оскільки процес обробки масивів даних ними є недосконалий. Ці обставини обумовили необхідність розробки ї бази даних, застосування якої сприяло б їх інтенсивному використанню. Створення баз даних та управління ними здійснюються на основі обраної логічної моделі даних, яка виступає як невід’ємний елемент створення та реалізації сучасних баз даних та систем управління ними. Під логічною моделлю даних розуміється модель, що відображає логічні взаємо-зв'язки між різними елементами даних без їх фізичної організації та змісту. У цьому логічна модель розробляється під конкретну реалізацію системи управління базами даних, і навіть враховуючи специфіку конкретної предметної області з урахуванням її концептуальної моделі. Можливості системи управління базами даних значною мірою обумовлені вибором моделі представлення даних, формування яких одна із найважливіших напрямів досліджень у галузі проектування баз даних. Можна стверджувати, що поява баз даних стала одним із найважливіших досягнень у галузі програмного забезпечення.
У статті розглянуто основні підходи що до вибору логічної структури баз даних для автоматизованої інформаційної системи органу військового управління, особливість яких базується на розробки єдиного інтегрованого підходу до проектування, який на етапі логічного проектування не буде залежати від специфіки конкретної системи управління базою даних і в той же час буде формально охоплювати весь цикл проектування.
Initial growth and chlorophyll indices of maize plants originating from seeds of different shapes and sizes
Authors: Santos Lucian Alex , Barbosa Benhur Schwartz , Pinto Carolina Cipriano , Szareski Vinícius Jardel , Carvalho Ivan Ricardo , Pimentel João Roberto , Troyjack Cristian , Rosa Tiago Corazza , Koch Felipe , Dubal Ítala Thaísa Padilha , Santos Ana Karina Carmo Ferreira , Schuch Luis Osmar Braga , Martinazzo Emanuela Garbin , Pedó Tiago , Aumonde Tiago Zanatta
Published: September 2023

The objective of this work was to evaluate the initial growth and chlorophyll content of maize plants originated from seeds with different sizes and shapes, as well as to establish the relationship between growth traits, chlorophyll index and seed formats. The experimental design was a randomized complete blocks, and the treatments were composed by seeds of four sizes and shapes for each of the two genotype used, and four collection periods (21, 24, 27 and 30 DAE) and four replications. The root and shoot length, stem diameter, leaf area, dry mass of leaf, stem, roots and total, leaf mass ratio, leaf area ratio, specific leaf area and chlorophyll a, b and total chlorophyll were determined. It was verified that seedlings of genotype "A" originated from large round seeds, presented the highest stem diameter, leaf dry mass, stem dry mass, root dry mass and total dry mass. There is a distinct response in the growth of maize plants as a function of the genotype. Regardless of the genotype, the size and shape of seeds do not influence the indexes of chlorophyll a, b and total. There is a positive and strong correlation between seeds of different sizes and shapes with leaf area, leaf dry mass and specific leaf area.
Calculation Array Solar Panel Capacity of 50 kWP Pamulang University South Tangerang
Authors: Triyanto Aripin , Rozak Ojak Abdul , Aditya Aditya
Published: September 2023

Pamulang University is located in the South Tangerang area consisting of three buildings and 6 faculties and 5 of them are engineering faculties. Currently implementing Solar Panels is being carried out by the Faculty of Electrical Engineering, namely the application of new renewable energy sources. Installation of a solar power plant with a capacity of 50 KWP On-Grid is used as a provider of electricity for building lighting. The purpose of calculating the number of arrays is to determine the area and output power of the arranged solar panels. The problems faced before installation are the number of solar panels that will be arranged in the rooftop area, the amount of solar radiation and the output power. The use of research methods through the stages of calculation, monitoring, and standardization references was carried out for two weeks. The measuring instrument used in the research is the Seaward Solar Survey 200R, while the Global Solar Atlas (GSA) is used as a reference for insolation values in December 2022. The calculation results for the area of the array are 325.62 m², the PLTS electrical energy (EL) calculation is 393, 12 kWh, GSA of 6.14 kWh /m²/day, temperature correction factor (TCF) of 0.96, number of PLTS 102 solar panels with 6 PV strings, highest inverter output of 272.8 kWh and lowest value of 133.2 kWh
Worst of Friends, Best of Rivals: Agency vs Structure in Turkey-Russia Relations
Authors: BECHEV Dimitar
Published: September 2023

The article studies the dynamics behind the unprecedented rapprochement between Turkey and Russia since the 2000s. It explains the growing degree of co-operation between Ankara and Moscow through the role of political leadership as well as to Turkey’s adjustment to the changing balance of power at the regional and global level. At the same time, the article highlights the competitive aspects of the relationship. It does so with reference to a series of case studies: the war in Syria, Turkey’s intervention in Libya since 2019, the purchase of S-400 surface to air missiles, energy security in the Black Sea the Southern Caucasus, and Turkey’s response to Russia’s full scale invasion of Ukraine in February 2022.
USE OF HISTORICAL PAINTINGS IN ADVERTISEMENTS THROUGH YEARS AND ITS IMPACT ON CONSUMERS: A CASE STUDY
Authors:   Maharashtra, Paul Mekhla , Paul Megha ,   Maharashtra
Published: September 2023

This case study explores the evolution, idea, impact, and reasons for using historical paintings in advertisements over the years. This paper will also analyze various advertisement campaigns and their popularity and effectiveness on the consumers and enhancement of brand messaging. This study will also try to elucidate the strategies used by advertisers to clout the power of historical artworks to grab the attention of consumers and possible customers. This paper will also try to investigate the ethical considerations surrounding the usage of historical paintings in advertisements and their significance for both the art world and the advertising industry.
AGGREGATION AND HYBRID APPROACHES USING BPSO AND BGWO FOR FEATURE SELECTION FOR INDIAN STOCK INDEX PRICE PREDICTION USING GRU
Authors: Gupta Priyank , Gupta Sanjay Kumar ,   Jiwaji University, Singh Jadon Rakesh ,   MITS
Published: September 2023

The stock exchange is a significant component of the economy, and forecasting its development is essential. Several deep-learning time series models based on RNN and its variants are used to forecast the stock market, but their accuracy still needs to be improved. Optimization strategies, such as GA, PSO, GWO, and others, have been used to enhance the reliability of these models. In this proposed paper, we have used the Binary GWO and Binary PSO algorithms to optimize the input characteristics of a two-layer GRU model for forecasting Indian stock index price. To increase the accuracy of these models, we have suggested two distinct approaches: Aggregation Method and the Hybrid method. In the 10- year time frame, the data indicated that the aggregation approach produced superior accuracy than standard Binary GWO and Binary PSO independently. Although the suggested hybrid method did not out perform individual Binary PSO methods in terms of accuracy, it performed better than the Binary GWO model in a 10- year time frame. Moreover, it showed promise for future improvement. The proposed approaches have the potential to make essential contributions to the index of stock price forecasting, particularly in the Indian market.
INTERCROPPING: PROSPECTS AND CHALLENGES IN BANGLADESH FOR SUSTAINABLE AGRICULTURE
Authors: Akter Asia , Abul Ulie Kazim Khan , Ali Samiha Suhrah ,   University of Idaho
Published: September 2023

— Intercropping, as an innovative and sustainable agricultural practice, offers a wide range of benefits that make it a valuable approach to modern farming systems. By simultaneously cultivating two or more different crop species within the same field or growing area, intercropping harnesses the power of biodiversity and ecological interactions to optimize resource utilization, enhance productivity, promote environmental sustainability, and contribute to the economic resilience of farming communities. Agriculture is the backbone of the Bangladeshi economy and plays a crucial role in GDP (12.5%, Fiscal year; 2021-2022). Intercropping has the potential to deliver several positive economic impacts on the Bangladesh's economy. Despite its numerous benefits, the adoption of intercropping in Bangladesh faces some challenges, including limited access to technical knowledge, availability of suitable crop combinations, and market demand for intercropped products. To promote intercropping effectively, there is a need for targeted extension services, farmer training, and policy support that incentivizes sustainable agricultural practices and financial support to adopt and implement intercropping practices effectively. By enhancing agricultural productivity, reducing input costs, and promoting sustainable practices, intercropping can contribute to poverty reduction, rural development, and improved livelihoods for smallholder farmers across the country.
Analyzing Passing Metrics in Ice Hockey using Puck and Player Tracking Data
Authors: Radke David , Lu Jaxin , Woloschuk Jackson , Le Tin , Radke Daniel , Liu Charlie , Brecht Tim
Published: September 2023

Traditional ice hockey statistics are inherently biased towards offensive events like goals, assists, and shots. However, successful teams in ice hockey require players with skills that may not be captured using traditional measures of performance. The adoption of puck and player tracking systems in the National Hockey League (NHL) has significantly increased the scope of possible metrics that can be obtained. In this paper, we compute recently proposed passing metrics from 1221 NHL games from the 2021-2022 season. We analyze the distributions of values obtained for each player for each metric to understand the variance between, and within, different positions. We find that forwards tend to complete fewer passes with smaller passing lanes, while defensemen pass to forwards significantly more than their defensive partners . Additionally, because these new metrics do not correlate well with traditional metrics (e.g., assists), we believe that they capture aspects of players’ abilities that may not appear on the game sheet.
Система ценностных ориентиров калининградской молодежи: устойчивые приоритеты и их осмысление The Value Orientations of Kaliningrad Youth: Consistent Priorities and Their Understanding
Authors: Zimovina E. P. , Krishtal M. I.
Published: September 2023

Статья посвящена изучению системы ценностных ориентиров калининградской молодежи. Исследование было проведено поэтапно, с использованием количественных и качественных методов в период с апреля по июнь 2022 г. На первом этапе был разработан топик‑гайд и проведены пять фокус‑групп с представителями молодежи в возрасте 18–35 лет, проживающими в Калининграде. На втором этапе был проведен социологический опрос калининградской молодежи (n=899). Выявлено, что доминирующее место в системе ценностей рассматриваемой возрастной группы населения Калининграда занимают семья, любовь и дружба. Наряду с этим обнаружен высокий запрос на такие ценности социального характера, как справедливость и равенство. Причем данные понятия являются смежными для молодежи, большинство которой рассматривает справедливость, в первую очередь, как равенство возможностей. В сознании молодых людей зафиксирован симбиоз коллективных и индивидуалистских ценностей: заявляя о приоритетности личных интересов, респонденты нередко отмечали готовность пожертвовать ими ради интересов общества. Обнаружены некоторые гендерные и возрастные отличия в восприятии ряда ценностей, в частности любви и свободы. The paper aims to study the system of the value orientations of Kaliningrad youth. The study was conducted in stages, using quantitative and qualitative methods in the period from April to June 2022. At the first stage a topic guide was developed, and five focus groups were held with representatives of young people aged 18–35 years living in Kaliningrad. At the second stage, a sociological survey of Kaliningrad youth was conducted (n=899). It was revealed that family, love and friendship dominate in the value system of the studied age group of the Kaliningrad population. At the same time, there is a high demand for such social values as justice and equality. These concepts are related for young people, most of whom consider justice, first of all, as equality of opportunity. Collective and individualistic values were shown to coexist in the minds of young people: stating the priority of personal interests, respondents often mentioned their willingness to sacrifice them for the sake of the interests of society. Some gender and age differences were found in the perception of several values, in particular love and freedom.
PERANCANGAN GAME EDUKASI PEMBELAJARAN BAHASA PEMROGRAMAN JAVA BERBASIS ANDROID
Authors: Windy Windy , Fajrin Alfannisa Annurrullah
Published: September 2023

Digital education is currently very developed in the field of technology which has learning facilities with educational games so that lessons will be easier to understand and more interesting. while studying the Java programming language is known as learning that teaches the basics of programming languages based on android. while learning at BATAM ADVENT VOCATIONAL SCHOOL uses guidebooks that can be obtained by teachers from the internet using traditional methods making it difficult for students to learn Java, because the teacher only delivers lessons in front of the class and students only listen to the lessons delivered by the teacher. The method used to design educational games for learning the Java programming language based on Android is the Game Development Life Cycle (GDLC) and Unified Modeling Language (UML) methods, making games using Unity. The research is educational games for learning the Java programming language based on Android which can be used as learning media at ADVENT BATAM Vocational Schools, to add insight and knowledge to students about Java programming.
ANALISIS KUALITAS PELAYANAN PERPUSTAKAAN TERHADAP KEPUASAN PENGUNJUNG PADA PERPUSTAKAAN SEKOLAH KRISTEN BASIC
Authors: Dachi Markus Gunawan , Sugianto Welly
Published: September 2023

Competition in the field of educational services, one of which relies on the ability of school libraries to provide satisfactory service quality to library visitors as service users. To measure the tangible or intangible quality of service, the level of visitor satisfaction can be measured. Libraries should regularly measure visitor satisfaction as an evaluation material to improve the quality of their services. This study was conducted to determine the influence of tangible, reliability, responsiveness, assurance, and empathy dimensions of service quality provided by the Basic Christian School library on visitor satisfaction. This study is a quantitative research model using the Service Quality method and linear regression. Service Quality is one of the methods used to measure visitor satisfaction with the quality of school library services. The measurement in the Service Quality method is divided into 5 dimensions: tangible, reliability, responsiveness, assurance, and empathy. In addition, regression analysis is conducted to determine the level of relationship between independent and dependent variables in this study. The research instrument used consists of 30 items of service quality and visitor satisfaction questionnaires adapted from Basuki (2019). The respondents in this study were 154 students from Basic Christian Junior High School and High School. The results of the study showed that variables with positive coefficients had an impact on increasing visitor satisfaction.
APLIKASI PENGENALAN OBJEK WISATA KEPULAUAN RIAU MENGGUNAKAN METODE SOFTWARE DEVELOPMENT LIFE CYCLE
Authors: Rosmawati Rosmawati , Hutabri Ellbert
Published: September 2023

The Riau Archipelago is a place that has many tourist objects, one of which is in Batam City. Batam City is one of the largest cities in the Riau Archipelago Province, strategically located very close to international waterways, direct widening with the Singapore Strait and the Malaysia Strait. Tourism object is everything that exists in a tourist destination area which is an attraction so that people want to come to visit that place, all places or natural conditions that have tourist resources that are built and developed so that they have an attraction and are cultivated as a place to visit. traveler. However, currently there is no application that helps the public to introduce tourist objects and forms of marketing or marketing tourism objects in Batam City for foreign tourists is very difficult. So with this Android-based application for recognizing tourist objects in the Riau Islands to make it easier or to get to know tourist objects in the Riau Islands, and to make it easier to find locations for tourist objects in the Riau Islands. Its creation in mobile form aims to make it easy to carry anywhere. with this an application will be created using Adobe Animate. This research method uses the SDLC (Software Development Life Cycle) method with the aim of introducing natural tourism objects in the Riau Archipelago and the design uses UML (Unified Modeling Language).
RANCANG BANGUN SISTEM INFORMASI KEPEGAWAIAN BERBASIS WEB PADA PT SRI INDAH MANDIRI
Authors: Carlos Carlos daniel , Ridho Muhammat Rasid
Published: September 2023

Today's technology has developed rapidly. This can be seen from the many uses of technology in everyday human life. PT Sri Indah Mandiri is a company that has been established since 1997 which is engaged in manufacturing to provide building materials. So far, the administrative recording process for the presence of PT Sri Indah Mandiri still relies on the application of Ms. Excel and printed documents resulting in an increasing number of accumulations of attendance data and searching for data takes quite a long time. In addition, the calculation of overtime is still done manually, so it often causes errors in the process of calculating employee overtime. This study aims to design a staffing information system at PT Sri Indah Mandiri to improve and facilitate the process of recording attendance at PT Sri Indah Mandiri. The system development method used is the Agile Scrum SDLC method. The results of the system design show that the system improves and facilitates the process of recording attendance so that it can make PT Sri Indah Mandiri operate more effectively and efficiently in its business activities.
IMPLEMENTASI DATA MINING MINAT CUSTOMER TOKO DURIAN KIMHUI DENGAN ALGORITMA APRIORI
Authors: Bryan Vincentsius Oliver Bryan , Handoko Koko Handoko
Published: September 2023

Tanaman durian adalah tanaman perkebunan yang berasal dari negara yang beriklim tropis. Tanaman durian ini sangat berpotensi untuk dikembangkan yang didukung oleh beberapa faktor seperti minat yang tinggi terhadap buah durian, Tanjung Batu merupakan produksi dari tanaman durian yang di ambil bibitnya dari negara Malaysia langsung dan ditanam di pulau Tanjung Batu, orang Batam sangat mengenal durian yang berasal dari Tanjung Batu dikarenakan rasa dan buahnya hampir sama persis seperti buah yang ditanam di negara Malaysia jenis - jenisnya sama seperti yang ada di negara Malaysia itu sendiri hanya berbeda tempat ditanamnya saja banyak orang batam yang membeli bibit durian dari Malaysia untuk ditanam dikarenakan ada yang hobby ada juga yang ingin memulai bisnis buah durian, dengan objek penelitian durian peneliti melakukan observasi terhadap penjualan durian dengan menggunakan metode algoritma apriori dibantu dengan software Rapidminer dan peneliti akan mendapatkan hasil dari perhitungan penjualan yang paling banyak diminati dan dicari oleh konsumen yaitu didapati jenis durian Musangking yang paling banyak diminati oleh konsumen karena durian Musangking memiliki rasa yang berbeda diantara durian lainnya dan juga musangking memiliki warna daging yang cantik oleh karena itu durian musangking memiliki banyak peminat, dan juga durian musangking mendapatkan nilai yang paling tinggi dalam perhitungan di aplikasi tersebut yaitu mendapatkan 100% nilai support tertinggi.
Identification of differences in gene expression implicated in the Adherent-Invasive Escherichia coli phenotype during in vitro infection of intestinal epithelial cells
Authors: Bonet-Rossinyol Queralt , Camprubí-Font Carla , López-Siles Mireia , Martinez-Medina Margarita
Published: September 2023

Introduction

Adherent-invasive Escherichia coli (AIEC) is strongly associated with the pathogenesis of Crohn’s disease (CD). However, no molecular markers currently exist for AIEC identification. This study aimed to identify differentially expressed genes (DEGs) between AIEC and non-AIEC strains that may contribute to AIEC pathogenicity and to evaluate their utility as molecular markers.

Methods

Comparative transcriptomics was performed on two closely related AIEC/non-AIEC strain pairs during Intestine-407 cell infection. DEGs were quantified by RT-qPCR in the same RNA extracts, as well as in 14 AIEC and 23 non-AIEC strains to validate the results across a diverse strain collection. Binary logistical regression was performed to identify DEGs whose quantification could be used as AIEC biomarkers.

Results

Comparative transcriptomics revealed 67 differences in expression between the two phenotypes in the strain pairs, 50 of which (81.97%) were corroborated by RT-qPCR. When explored in the whole strain collection, 29 DEGs were differentially expressed between AIEC and non-AIEC phenotypes (p-value < 0.042), and 42 genes between the supernatant fraction of infected cell cultures and the cellular fraction containing adhered and intracellular bacteria (p-value < 0.049). Notably, six DEGs detected in the strain collection were implicated in arginine biosynthesis and five in colanic acid synthesis. Furthermore, two biomarkers based on wzb and cueR gene expression were proposed with an accuracy of ≥ 85% in our strain collection.

Discussion

This is the first transcriptomic study conducted using AIEC-infected cell cultures. We have identified several genes that may be involved in AIEC pathogenicity, two of which are putative biomarkers for identification.
Risk assessment of debris flow disaster in mountainous area of northern Yunnan province based on FLO-2D under the influence of extreme rainfall
Authors: Ding Xing-Yu , Hu Wen-Jun , Liu Fang , Yang Xian
Published: September 2023

The stratum in Yunlong mountain area is unstable, and it is more likely to have extreme damage to the mountain in extreme rainfall weather, and even cause the occurrence of mountain disasters such as debris flow. This paper conducted field geological surveys and used the FLO-2D professional simulation system to scientifically evaluate the risk probability of three debris flow in Yunlong County. The risk prediction before and after engineering control was compared for the county’s urban areas.This paper uses construction drawings and remote sensing images to assist in positioning methods for debris flow simulation. After dividing the debris flow simulation grid, the control project is added to the simulation project in the form of a plug-in, and specific engineering parameters are imported into the simulation project file by modifying its properties. The setting of the control project in numerical simulation is completed, solving the problem of setting engineering measures. By this method, the probability analysis of debris flow under three different rainfall frequencies of 1%, 2% and 5%, namely once in 20 years, once in 50 years and once in 100 years, is simulated, and the flow and sedimentation characteristics of debris flow before and after engineering control are compared. The results show that under 5% rainfall frequency, the simulated results before engineering control were compared with the actual deposition range, and the evaluation accuracy is within a reasonable error range. After debris flow engineering control, the proportion of high risk areas of debris flow in urban areas decreased significantly, especially when the frequency of rainfall was once in 100 years, and the area of non-danger areas increased by 5.92% compared with that before control. In the end, this paper combines the depth of mud, the velocity of mud and the outbreak frequency to get the debris flow risk assessment map before and after engineering treatment, and puts forward suggestions for further prevention and control measures of debris flow disaster. The research results of this paper will provide good guidance for the occurrence and control of debris flow hazards under the influence of extreme rainfall in the mountainous area of northern Yunnan.
An emerging research: the role of hepatocellular carcinoma-derived exosomal circRNAs in the immune microenvironment
Authors: Xu Huang-Zhen , Lin Xin-Yi , Xu Yun-Xian , Xue Hui-Bin , Lin Shu , Xu Tian-Wen
Published: September 2023

Hepatocellular carcinoma (HCC), the most common primary malignancy of the liver, is one of the leading causes of cancer-related death and is associated with a poor prognosis. The tumor microenvironment (TME) of HCC comprises immune, immunosuppressive, and interstitial cells with hypoxic, angiogenic, metabolic reprogramming, inflammatory, and immunosuppressive features. Exosomes are nanoscale extracellular vesicles that secrete biologically active signaling molecules such as deoxyribonucleic acid (DNA), messenger ribonucleic acid (mRNA), microribonucleic acid (miRNA), proteins, and lipids. These signaling molecules act as messengers in the tumor microenvironment, especially the tumor immunosuppressive microenvironment. Exosomal circRNAs reshape the tumor microenvironment by prompting hypoxic stress response, stimulating angiogenesis, contributing to metabolic reprogramming, facilitating inflammatory changes in the HCC cells and inducing tumor immunosuppression. The exosomes secreted by HCC cells carry circRNA into immune cells, which intervene in the activation of immune cells and promote the overexpression of immune checkpoints to regulate immune response, leading tumor cells to acquire immunosuppressive properties. Furthermore, immunosuppression is the final result of a combination of TME-related factors, including hypoxia, angiogenesis, metabolic reprogramming, and inflammation changes. In conclusion, exosomal circRNA accelerates the tumor progression by adjusting the phenotype of the tumor microenvironment and ultimately forming an immunosuppressive microenvironment. HCC-derived exosomal circRNA can affect HCC cell proliferation, invasion, metastasis, and induction of chemoresistance. Therefore, this review aimed to summarize the composition and function of these exosomes, the role that HCC-derived exosomal circRNAs play in microenvironment formation, and the interactions between exosomes and immune cells. This review outlines the role of exosomal circRNAs in the malignant phenotype of HCC and provides a preliminary exploration of the clinical utility of exosomal circRNAs.
Pemphigus vulgaris as an immune-related adverse event in recurrent metastatic esophageal squamous cell carcinoma treated with ipilimumab plus nivolumab: a case report and literature review
Authors: Nakamura Hajime , Shionoya Aika , Arihara Yohei , Hayasaka Naotaka , Kubo Tomohiro , Usami Makoto , Sugita Shintaro , Uhara Hisashi , Takada Kohichi
Published: September 2023

Ipilimumab plus nivolumab therapy is approved for patients with unresectable advanced esophageal squamous cell carcinoma (ESCC). Although a combination of immune checkpoint inhibitors (ICIs), compared to conventional chemotherapy, can improve overall survival in patients with advanced ESCC, this increases the incidence of immune-related adverse events (irAEs). Here, we describe an ESCC case that developed pemphigus vulgaris (PV), an extremely rare cutaneous irAE, during ipilimumab plus nivolumab treatment. The patient achieved a partial response to treatment. The PV was successfully managed after the cessation of ipilimumab and the use of a topical steroid. We should thus re-treat ESCC with nivolumab monotherapy. In the era of ICIs as standard cancer therapeutics, diagnostic criteria for blistering diseases need to be established to properly manage patients with cutaneous irAEs.
Overcoming the therapeutic limitations of EZH2 inhibitors in Burkitt’s lymphoma: a comprehensive study on the combined effects of MS1943 and Ibrutinib
Authors: Jeong Yurim , Kim Se Been , Yang Chae-Eun , Yu Min Seo , Choi Wan-Su , Jeon Youngwoo , Lim Jung-Yeon
Published: September 2023

Enhancer of zeste homolog 2 (EZH2) and Bruton’s tyrosine kinase (BTK) are both key factors involved in the development and progression of hematological malignancies. Clinical studies have demonstrated the potential of various EZH2 inhibitors, which target the methyltransferase activity of EZH2, for the treatment of lymphomas. However, despite their ability to effectively reduce the H3K27me3 levels, these inhibitors have shown limited efficacy in blocking the proliferation of lymphoma cells. To overcome this challenge, we employed a hydrophobic tagging approach utilizing MS1943, a selective EZH2 degrader. In this study, we investigated the inhibitory effects of two drugs, the FDA-approved EZH2 inhibitor Tazemetostat, currently undergoing clinical trials, and the novel drug MS1943, on Burkitt’s lymphoma. Furthermore, we assessed the potential synergistic effect of combining these drugs with the BTK inhibitor Ibrutinib. In this study, we evaluated the effects of combination therapy with MS1943 and Ibrutinib on the proliferation of three Burkitt’s lymphoma cell lines, namely RPMI1788, Ramos, and Daudi cells. Our results demonstrated that the combination of MS1943 and Ibrutinib significantly suppressed cell proliferation to a greater extent compared to the combination of Tazemetostat and Ibrutinib. Additionally, we investigated the underlying mechanisms of action and found that the combination therapy of MS1943 and Ibrutinib led to the upregulation of miR29B-mediated p53-upregulated modulator of apoptosis PUMA, BAX, cleaved PARP, and cleaved caspase-3 in Burkitt’s lymphoma cells. These findings highlight the potential of this innovative therapeutic strategy as an alternative to traditional EZH2 inhibitors, offering promising prospects for improving treatment outcomes in Burkitt’s lymphoma.
A multimodal dialog approach to mental state characterization in clinically depressed, anxious, and suicidal populations
Authors: Cohen Joshua , Richter Vanessa , Neumann Michael , Black David , Haq Allie , Wright-Berryman Jennifer , Ramanarayanan Vikram
Published: September 2023

Background

The rise of depression, anxiety, and suicide rates has led to increased demand for telemedicine-based mental health screening and remote patient monitoring (RPM) solutions to alleviate the burden on, and enhance the efficiency of, mental health practitioners. Multimodal dialog systems (MDS) that conduct on-demand, structured interviews offer a scalable and cost-effective solution to address this need.

Objective

This study evaluates the feasibility of a cloud based MDS agent, Tina, for mental state characterization in participants with depression, anxiety, and suicide risk.

Method

Sixty-eight participants were recruited through an online health registry and completed 73 sessions, with 15 (20.6%), 21 (28.8%), and 26 (35.6%) sessions screening positive for depression, anxiety, and suicide risk, respectively using conventional screening instruments. Participants then interacted with Tina as they completed a structured interview designed to elicit calibrated, open-ended responses regarding the participants' feelings and emotional state. Simultaneously, the platform streamed their speech and video recordings in real-time to a HIPAA-compliant cloud server, to compute speech, language, and facial movement-based biomarkers. After their sessions, participants completed user experience surveys. Machine learning models were developed using extracted features and evaluated with the area under the receiver operating characteristic curve (AUC).

Results

For both depression and suicide risk, affected individuals tended to have a higher percent pause time, while those positive for anxiety showed reduced lip movement relative to healthy controls. In terms of single-modality classification models, speech features performed best for depression (AUC = 0.64; 95% CI = 0.51–0.78), facial features for anxiety (AUC = 0.57; 95% CI = 0.43–0.71), and text features for suicide risk (AUC = 0.65; 95% CI = 0.52–0.78). Best overall performance was achieved by decision fusion of all models in identifying suicide risk (AUC = 0.76; 95% CI = 0.65–0.87). Participants reported the experience comfortable and shared their feelings.

Conclusion

MDS is a feasible, useful, effective, and interpretable solution for RPM in real-world clinical depression, anxiety, and suicidal populations. Facial information is more informative for anxiety classification, while speech and language are more discriminative of depression and suicidality markers. In general, combining speech, language, and facial information improved model performance on all classification tasks.
Translating evidence-based knowledge objects into practice
Authors: Scheuer John Damm
Published: September 2023

This paper aims to show how organizational translation theories and models may supplement implementation science with a new process perspective on how knowledge objects such as Cochrane reviews, clinical guidelines and reference programs are implemented in practice in healthcare organizations. They build on Bruno Latour's idea about translation that states that the spread in time and space of anything—including knowledge objects—is in the hands of people and that each of these people may act in many different ways, letting the token drop, modifying it, deflecting it, betraying it, adding to it, or appropriating it. Implementation science theories, models and frameworks often try to identify general aspects of processes and variables that influence implementation processes. In contrast, translation theories and models build on a process view that uses the sequence of events, activities and choices by translators situated in time as well as in space to explain how outcomes of translation/implementation processes came about. The paper develops some implementation relevant propositions about translation of knowledge objects in healthcare organizations that may inform further research. Moreover, it discusses how organizational translation studies and implementation science may supplement each other.
Computing the Matrix Logarithm with the Romberg Integration Method
Authors: Ibáñez Javier , Alonso José M. , Defez Emilio , Alonso-Jordá Pedro , Sastre Jorge
Published: September 2023

The matrix logarithm function has applicability in many engineering and science fields. Improvements in its calculation, from the point of view of both accuracy and/or execution time, have a direct impact on these disciplines. This paper describes a new numerical algorithm devoted to matrix logarithm computation and using the Romberg integration method, together with the inverse scaling and squaring technique. This novel method was implemented and compared with three different state-of-the-art codes, all based on Padé approximation. The experimental results, under a heterogeneous matrix test battery, showed that the new method was numerically stable, with an elapsed time midway among the other codes, and it generally offered a higher accuracy.