bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of 3-l- and 3-d-[18F]Fluorophenylalanines as PET Tracers for Tumor Imaging
Authors: Krämer Felicia , Gröner Benedikt , Hoffmann Chris , Craig Austin , Brugger Melanie , Drzezga Alexander , Timmer Marco , Neumaier Felix , Zlatopolskiy Boris D. , Endepols Heike , Neumaier Bernd
Published: December 2021

Purpose: The preclinical evaluation of 3-l- and 3-d-[18F]FPhe in comparison to [18F]FET, an established tracer for tumor imaging. Methods: In vitro studies were conducted with MCF-7, PC-3, and U87 MG human tumor cell lines. In vivo µPET studies were conducted in healthy rats with/without the inhibition of peripheral aromatic l-amino acid decarboxylase by benserazide pretreatment (n = 3 each), in mice bearing subcutaneous MCF-7 or PC-3 tumor xenografts (n = 10), and in rats bearing orthotopic U87 MG tumor xenografts (n = 14). Tracer accumulation was quantified by SUVmax, SUVmean and tumor-to-brain ratios (TBrR). Results: The uptake of 3-l-[18F]FPhe in MCF-7 and PC-3 cells was significantly higher relative to [18F]FET. The uptake of all three tracers was significantly reduced by the suppression of amino acid transport systems L or ASC. 3-l-[18F]FPhe but not 3-d-[18F]FPhe exhibited protein incorporation. In benserazide-treated healthy rats, brain uptake after 42–120 min was significantly higher for 3-d-[18F]FPhe vs. 3-l-[18F]FPhe. [18F]FET showed significantly higher uptake into subcutaneous MCF-7 tumors (52–60 min p.i.), while early uptake into orthotopic U87 MG tumors was significantly higher for 3-l-[18F]FPhe (SUVmax: 3-l-[18F]FPhe, 107.6 ± 11.3; 3-d-[18F]FPhe, 86.0 ± 4.3; [18F]FET, 90.2 ± 7.7). Increased tumoral expression of LAT1 and ASCT2 was confirmed immunohistologically. Conclusion: Both novel tracers enable accurate tumor delineation with an imaging quality comparable to [18F]FET.
Advances in the Knowledge of the Molecular Pathogenesis of High-Prevalence Tumors and Its Relevance for Their Future Clinical Management
Authors: Rodríguez Marta , Cristóbal Ion
Published: December 2021

This Special Issue aims to include relevant works that increase our knowledge about the molecular pathways that govern the development and progression of high-prevalence human cancers, which are responsible for most cancer-related deaths worldwide [...]
Molecular Alterations Associated with Acquired Drug Resistance during Combined Treatment with Encorafenib and Binimetinib in Melanoma Cell Lines
Authors: Patel Vikas , Szász István , Koroknai Viktória , Kiss Tímea , Balázs Margit
Published: December 2021

Combination treatment using BRAF/MEK inhibitors is a promising therapy for patients with advanced BRAFV600E/K mutant melanoma. However, acquired resistance largely limits the clinical efficacy of this drug combination. Identifying resistance mechanisms is essential to reach long-term, durable responses. During this study, we developed six melanoma cell lines with acquired resistance for BRAFi/MEKi treatment and defined the molecular alterations associated with drug resistance. We observed that the invasion of three resistant cell lines increased significantly compared to the sensitive cells. RNA-sequencing analysis revealed differentially expressed genes that were functionally linked to a variety of biological functions including epithelial-mesenchymal transition, the ROS pathway, and KRAS-signalling. Using proteome profiler array, several differentially expressed proteins were detected, which clustered into a unique pattern. Galectin showed increased expression in four resistant cell lines, being the highest in the WM1617E+BRes cells. We also observed that the resistant cells behaved differently after the withdrawal of the inhibitors, five were not drug addicted at all and did not exhibit significantly increased lethality; however, the viability of one resistant cell line (WM1617E+BRes) decreased significantly. We have selected three resistant cell lines to investigate the protein expression changes after drug withdrawal. The expression patterns of CapG, Enolase 2, and osteopontin were similar in the resistant cells after ten days of “drug holiday”, but the Snail protein was only expressed in the WM1617E+BRes cells, which showed a drug-dependent phenotype, and this might be associated with drug addiction. Our results highlight that melanoma cells use several types of resistance mechanisms involving the altered expression of different proteins to bypass drug treatment.
The Influence of Precursor on the Preparation of CeO2 Catalysts for the Total Oxidation of the Volatile Organic Compound Propane
Authors: Aggett Kieran , Davies Thomas E. , Morgan David J. , Hewes Dan , Taylor Stuart H.
Published: December 2021

CeO2 catalysts were prepared by a precipitation method using either (NH4)2Ce(NO3)6 or Ce(NO3)3, as CeIV or CeIII precursors respectively. The influence of the different precursors on catalytic activity was evaluated for the total oxidation of propane with water present in the feed. The catalyst prepared using the CeIV precursor was more active for propane total oxidation. The choice of precursor influenced catalyst properties such as surface area, reducibility, morphology, and active oxygen species. The predominant factor associated with the catalytic activity was related to the formation of either CeO2.nH2O or Ce2(OH)2(CO3)2.H2O precipitate species, formed prior to calcination. The formation of CeO2.nH2O resulted in enhanced surface area which was an important factor for controlling catalyst activity.
A Conceptual Framework for Biointelligent Production—Calling for Systemic Life Cycle Thinking in Cellular Units
Authors: Miehe Robert , Buckreus Lorena , Kiemel Steffen , Sauer Alexander , Bauernhansl Thomas
Published: December 2021

A sustainable design of production systems is essential for the future viability of the economy. In this context, biointelligent production systems (BIS) are currently considered one of the most innovative paths for a comprehensive reorientation of existing industrial patterns. BIS are intended to enable a highly localized on-demand production of personalized goods via stand-alone non-expert systems. Recent studies in this field have primarily adopted a technical perspective; this paper addresses the larger picture by discussing the essential issues of integrated production system design. Following a normative logic, we introduce the basic principle of systemic life cycle thinking in cellular units as the foundation of a management framework for BIS. Thereupon, we develop a coherent theoretical model of a future decentralized production system and derive perspectives for future research and development in key areas of management.
Knowledge, Attitude and Perception towards COVID-19 Pandemic among Veterinary Professionals and Impacts: A Cross-Sectional Nationwide-Based Survey
Authors: Adenubi Olubukola , Adebowale Oluwawemimo , Adesokan Hezekiah , Oloye Abimbola , Bankole Noah , Fadipe Oladotun , Ayo-Ajayi Patience , Akinloye Adebayo
Published: December 2021

This study evaluated the knowledge, attitude and perception (KAP) towards COVID-19 pandemic control among veterinarians in Nigeria. A nation-wide web-based cross-sectional survey was conducted. Information on KAP towards the COVID-19 pandemic was gathered (April 23 and May 31, 2020) and multivariate logistic regression was performed to identify associated factors. A total of 368 veterinarians participated in the study. The majority of respondents were males (72.8%), between the ages of 30–39 years (39.7%). Generally, respondents displayed a good level of knowledge about COVID-19 (72.4% ± 9.9%, range 44.1–91.2%), while the general attitude level was poor (65.4% ± 10.8, range 35.3–94.1%). Various determinants for good attitude among respondents were: if they were above 60 years old (aOR = 4.49, 95% CI: 1.379–14.594, p = 0.013), possessed postgraduate qualification (aOR = 1.63, 95 CI: 1.045–2.553, p = 0.031), worked over 30 years post DVM (aOR = 5.63, 95% CI: 1.966–16.100, p = 0.001), had household members between five and 10 (aOR = 1.73, 95% CI: 1.130–2.641, p = 0.012), and if respondents’ residence was on total lockdown (aOR = 1.66, 95% CI: 1.070–2.590, p = 0.024). The pandemic had moderate impacts on social, financial and physical status of the participants. Stricter policy measures and educational programs should be implemented to keep veterinarians and the populace informed about the best practices recommended for COVID-19 management.
Molecular Dynamics and Kinetics of Isothermal Cold Crystallization in the Chiral Smectogenic 3F7FPhH6 Glassformer
Authors: Deptuch Aleksandra , Jasiurkowska-Delaporte Małgorzata , Juszyńska-Gałązka Ewa , Drzewicz Anna , Zając Wojciech , Urbańska Magdalena
Published: December 2021

An investigation of the glass transition of the antiferroelectric smectic CA* phase and cold crystallization of (S)-4′-(1-methylheptylcarbonyl)biphenyl-4-yl 4-[7-(2,2,3,3,4,4,4-heptafluoro- butoxy)heptyl-1-oxy]benzoate (denoted as 3F7FPhH6) by differential scanning calorimetry, polarizing optical microscopy and broadband dielectric spectroscopy is presented. The fragility index mf = 72, classifying 3F7FPhH6 as a glassformer with intermediate fragility, was obtained from the temperature dependence of the α-process relaxation time, measured upon cooling. Duplication of the α-process was observed exclusively upon heating, before the onset of cold crystallization, and is connected with the pre-transitional effect. The presence of two crystal phases likely influences the kinetics of cold crystallization; the idea stems from a comparison with previous results for the 3F7HPhF6 and 3F7HPhH7 compounds. Additionally, the presence of the smectic Cα* sub-phase in a narrow temperature range was proved based on the differential scanning calorimetry and broadband dielectric spectroscopy results, as well as the fractal dimension analysis of the textures obtained by polarizing optical microscopy.
Bacterial Communities Associated with the Cycling of Non-Starch Polysaccharides and Phytate in Aquaponics Systems
Authors: Menezes-Blackburn Daniel , Al-Mahrouqi Nahad , Al-Siyabi Buthaina , Al-Kalbani Adhari , Greiner Ralf , Dobretsov Sergey
Published: December 2021

Aquaponics are efficient systems that associate aquatic organisms’ production and plants by recirculating water and nutrients between aquaculture and hydroponic tanks. In this study, we characterised the bacterial communities in the freshwater aquaponics system that can mineralise polysaccharides and phytate by producing carbohydrate-degrading enzymes and phytases, by 16S rRNA gene sequencing and in vitro culture techniques. Around 20% of the operational taxonomic units (zOTUs) identified were previously reported to carry fibre-degrading enzyme putative genes, namely β-glucanase (1%), xylanase (5%), or cellulases (17%). Ten % of the zOTUs were previously reported to carry putative genes of phytases with different catalytic mechanisms, namely β-propeller (6%), histidine acid phytases (3%), and protein tyrosine phytase (<1%). Thirty-eight morphologically different bacteria were isolated from biofilms accumulated in fish and plant compartments, and identified to belong to the Bacilli class. Among these, 7 could produce xylanase, 8 produced β-glucanase, 14 produced cellulase, and 11 isolates could secrete amylases. In addition, Staphylococcus sp. and Rossellomorea sp. could produce consistent extracellular phytate-degrading activity. The PCR amplification of β-propeller genes both in environmental samples and in the isolates obtained showed that this is the most ecologically relevant phytase type in the aquaponics systems used. In summary, the aquaponics system is abundant with bacteria carrying enzymes responsible for plant-nutrient mineralisation.
Investigating the Early Events after Skin-Barrier Disruption Using Microdialysis—A Human Ex Vivo Skin Model
Authors: Baumann Katrine , Knudsen Niels Peter Hell , Gadsbøll Anne-Sofie Østergaard , Woetmann Anders , Skov Per Stahl
Published: December 2021

Skin-barrier restoration following abrasive trauma is facilitated by mediator release from skin-resident cells, a process that has been investigated primarily in mice or simplified human systems with previous studies focusing on a limited number of biomarkers. Here, we demonstrate how early events caused by skin-barrier disruption can be studied in a human ex vivo skin model. Ten relevant biomarkers were recovered from the interstitial fluid by skin microdialysis with subsequent sample analysis using a multiplex platform. As a control, the biomarker profiles obtained from microdialysis sampling were compared to profiles of skin biopsy homogenates. We found that nine (GM-CSF, CXCL1/GROα, CXCL8/IL-8 CXCL10/IP-10, IL-1α, IL-6, MIF, TNF-α, and VEGF) of the 10 biomarkers were significantly upregulated in response to abrasive trauma. Only dialysate levels of CCL27/CTACK were unaffected by skin abrasion. Biomarker levels in the homogenates corresponded to dialysate levels for CCL27/CTACK, CXCL1/GROα, CXCL8/IL-8, and IL-6. However, IL-1α showed an inverse trend in response to trauma, and biopsy levels of MIF were unchanged. GM-CSF, CXCL10/IP-10, TNF-α, and VEGF were not detected in the biopsy homogenates. Our results suggest that the human ex vivo skin model is a reliable approach to study early events after disruption of the skin barrier.
Is the FINDRISC Tool Useful in Screening Type 2 Diabetes and Metabolic Syndrome in an African Setting? Experience among Young Adults in Urban Tanzania
Authors: Malindisa Evangelista Kenan , Balandya Emmanuel , Mashili Fredirick , Njelekela Marina
Published: December 2021

Background: Simple and less costly screening tools are needed to combat the rising non-communicable diseases epidemic. This study aimed to evaluate the utility of The Finnish Diabetes Risk Score (FINDRISC) as a screening tool for prediabetes, T2D, and metabolic syndrome (MetS) in a population of young adults in urban Mwanza, Tanzania. Methods: A cross-sectional community-based study was conducted among participants aged 18–35 years. The FINDRISC questionnaire was used to collect data and compute the FINDRISC scores for each participant. Socio-demographic, anthropometric, blood glucose, and lipid profiles data were collected accordingly. Results: A total of 259 participants were recruited into the study. The median age was 21 years (IQR 19–27), and more than half 60.2% (156) were females. In total, 32.8% (85) of the participants had at least a slightly elevated risk of developing T2D in 10 years’ time. Compared to the Oral Glucose Tolerance Test (OGTT), FINDRISC had a sensitivity and specificity of 39.1% and 69.2%, respectively (aROC = 0.5). The FINDRISC score significantly correlated with MetS (p = 0.001). Conclusion: In this study, FINDRISC has shown low sensitivity and specificity in the screening of pre-diabetes/T2D. However, it has potential utility in the screening of MetS in a young-adult population.
Fixed-Time Synchronization Control of Delayed Dynamical Complex Networks
Authors: Liu Mei , Lu Binglong , Li Zhanfeng , Jiang Haijun , Hu Cheng
Published: December 2021

Fixed-time synchronization problem for delayed dynamical complex networks is explored in this paper. Compared with some correspondingly existed results, a few new results are obtained to guarantee fixed-time synchronization of delayed dynamical networks model. Moreover, by designing adaptive controller and discontinuous feedback controller, fixed-time synchronization can be realized through regulating the main control parameter. Additionally, a new theorem for fixed-time synchronization is used to reduce the conservatism of the existing work in terms of conditions and the estimate of synchronization time. In particular, we obtain some fixed-time synchronization criteria for a type of coupled delayed neural networks. Finally, the analysis and comparison of the proposed controllers are given to demonstrate the validness of the derived results from one numerical example.
Towards a Measure for Characterizing the Informational Content of Audio Signals and the Relation between Complexity and Auditory Encoding
Authors: Guerrero Daniel , Rivera Pedro , Febres Gerardo , Gershenson Carlos
Published: December 2021

The accurate description of a complex process should take into account not only the interacting elements involved but also the scale of the description. Therefore, there can not be a single measure for describing the associated complexity of a process nor a single metric applicable in all scenarios. This article introduces a framework based on multiscale entropy to characterize the complexity associated with the most identifiable characteristic of songs: the melody. We are particularly interested in measuring the complexity of popular songs and identifying levels of complexity that statistically explain the listeners’ preferences. We analyze the relationship between complexity and popularity using a database of popular songs and their relative position in a preferences ranking. There is a tendency toward a positive association between complexity and acceptance (success) of a song that is, however, not significant after adjusting for multiple testing.
Affect-Logic, Embodiment, Synergetics, and the Free Energy Principle: New Approaches to the Understanding and Treatment of Schizophrenia
Authors: Ciompi Luc , Tschacher Wolfgang
Published: December 2021

This theoretical paper explores the affect-logic approach to schizophrenia in light of the general complexity theories of cognition: embodied cognition, Haken’s synergetics, and Friston’s free energy principle. According to affect-logic, the mental apparatus is an embodied system open to its environment, driven by bioenergetic inputs of emotions. Emotions are rooted in goal-directed embodied states selected by evolutionary pressure for coping with specific situations such as fight, flight, attachment, and others. According to synergetics, nonlinear bifurcations and the emergence of new global patterns occur in open systems when control parameters reach a critical level. Applied to the emergence of psychotic states, synergetics and the proposed energetic understanding of emotions lead to the hypothesis that critical levels of emotional tension may be responsible for the transition from normal to psychotic modes of functioning in vulnerable individuals. In addition, the free energy principle through learning suggests that psychotic symptoms correspond to alternative modes of minimizing free energy, which then entails distorted perceptions of the body, self, and reality. This synthetic formulation has implications for novel therapeutic and preventive strategies in the treatment of psychoses, among these are milieu-therapeutic approaches of the Soteria type that focus on a sustained reduction of emotional tension and phenomenologically oriented methods for improving the perception of body, self, and reality.
Transformation of Water Wave Spectra into Time Series of Surface Elevation
Authors: Oleinik Phelype Haron , Tavares Gabriel Pereira , Machado Bianca Neves , Isoldi Liércio André
Published: December 2021

Spectral wave modelling is widely used to simulate large-scale wind–wave processes due to its low computation cost and relatively simpler formulation, in comparison to phase-resolving or hydrodynamic models. However, some applications require a time-domain representation of sea waves. This article proposes a methodology to transform the wave spectrum into a time series of water surface elevation for applications that require a time-domain representation of ocean waves. The proposed method uses a generated phase spectrum and the inverse Fourier transform to turn the wave spectrum into a time series of water surface elevation. The consistency of the methodology is then verified. The results show that it is capable of correctly transforming the wave spectrum, and the significant wave height of the resulting time series is within 5% of that of the input spectrum.
Earthquake Reconnaissance Data Sources, a Literature Review
Authors: Contreras Diana , Wilkinson Sean , James Philip
Published: December 2021

Earthquakes are one of the most catastrophic natural phenomena. After an earthquake, earthquake reconnaissance enables effective recovery by collecting data on building damage and other impacts. This paper aims to identify state-of-the-art data sources for building damage assessment and provide guidance for more efficient data collection. We have reviewed 39 articles that indicate the sources used by different authors to collect data related to damage and post-disaster recovery progress after earthquakes between 2014 and 2021. The current data collection methods have been grouped into seven categories: fieldwork or ground surveys, omnidirectional imagery (OD), terrestrial laser scanning (TLS), remote sensing (RS), crowdsourcing platforms, social media (SM) and closed-circuit television videos (CCTV). The selection of a particular data source or collection technique for earthquake reconnaissance includes different criteria depending on what questions are to be answered by these data. We conclude that modern reconnaissance missions cannot rely on a single data source. Different data sources should complement each other, validate collected data or systematically quantify the damage. The recent increase in the number of crowdsourcing and SM platforms used to source earthquake reconnaissance data demonstrates that this is likely to become an increasingly important data source.
Sparse Signal Reconstruction on Fixed and Adaptive Supervised Dictionary Learning for Transient Stability Assessment
Authors: Dabou Raoult Teukam , Kamwa Innocent , Tagoudjeu Jacques , Mugombozi Francis Chuma
Published: December 2021

Fixed and adaptive supervised dictionary learning (SDL) is proposed in this paper for wide-area stability assessment. Single and hybrid fixed structures are developed based on impulse dictionary (ID), discrete Haar transform (DHT), discrete cosine transform (DCT), discrete sine transform (DST), and discrete wavelet transform (DWT) for sparse features extraction and online transient stability prediction. The fixed structures performance is compared with that obtained from transient K-singular value decomposition (TK-SVD) implemented while adding a stability status term to the optimization problem. Stable and unstable dictionary learning are designed based on datasets recorded by simulating thousands of contingencies with varying faults, load, and generator switching on the IEEE 68-bus test system. This separate supervised learning of stable and unstable scenarios allows determining root mean square error (RMSE), useful for online stability status assessment of new scenarios. With respect to the RMSE performance metric in signal reconstruction-based stability prediction, the present analysis demonstrates that [DWT], [DHT|DWT] and [DST|DHT|DCT] are better stability descriptors compared to K-SVD, [DHT], [DCT], [DCT|DWT], [DHT|DCT], [ID|DCT|DST], and [DWT|DHT|DCT] on test datasets. However, the K-SVD approach is faster to execute in both off-line training and real-time playback while yielding satisfactory accuracy in transient stability prediction (i.e., 7.5-cycles decision window after fault-clearing).
Application of Thermal and Cavitation Effects for Heat and Mass Transfer Process Intensification in Multicomponent Liquid Media
Authors: Pavlenko Anatoliy M. , Koshlak Hanna
Published: December 2021

In this paper, the authors consider the processes of dynamic interaction between the boiling particles of the dispersed phase of the emulsion leading to the large droplet breakup. Differences in the consideration of forces that determine the breaking of non-boiling and boiling droplets have been indicated in the study. They have been determined by the possibility of using the model to define the processes of displacement, deformation, or fragmentation of the inclusion of the dispersed phase under the influence of a set of neighboring particles. The dynamics of bubbles in a compressible liquid with consideration for interfacial heat and mass transfer has also been analyzed in the paper. The effect of standard and system parameters on the intensity of cavitation processes is considered. Physical transformations during the cavitation treatment of liquid are caused not only by shock waves and radiated pressure pulses but also by extreme thermal effects. At the stage of ultimate bubble compression, vapor inside the bubble and the liquid in its vicinity transform into the supercritical fluid state. The model analyzes microflow features in the inter-bubble space and quantitatively calculates local values of the velocity and pressure fields, as well as dynamic effects.
Key Factors Influencing the Achievement of Climate Neutrality Targets in the Manufacturing Industry: LMDI Decomposition Analysis
Authors: Dolge Kristiāna , Blumberga Dagnija
Published: December 2021

The manufacturing industry is often caught in the sustainability dilemma between economic growth targets and climate action plans. In this study, a Log-Mean Divisia Index (LMDI) decomposition analysis is applied to investigate how the amount of industrial energy-related CO2 emissions in Latvia has changed in the period from 1995 to 2019. The change in aggregate energy-related CO2 emissions in manufacturing industries is measured by five different factors: the industrial activity effect, structural change effect, energy intensity effect, fuel mix effect, and emission intensity effect. The decomposition analysis results showed that while there has been significant improvement in energy efficiency and decarbonization measures in industry, in recent years, the impact of the improvements has been largely offset by increased industrial activity in energy-intensive sectors such as wood processing and non-metallic mineral production. The results show that energy efficiency measures in industry contribute most to reducing carbon emissions. In the future, additional policies are needed to accelerate the deployment of clean energy and energy efficiency technologies.
The Problem of Smog-Particle Removal in Large Cities—Experimental Analysis of Some Filtration Materials
Authors: Ruciński Adam , Grzebielec Andrzej , Jaworski Maciej , Laskowski Rafał , Niewiński Grzegorz , Baryłka Adam , Rusowicz Artur
Published: December 2021

Air pollution is a significant problem in city centers. According to public health care in Poland, there is a need for local authorities to propose good purification solutions in both outdoor and indoor conditions. The main objective of this study is the development of an appropriate filtration system for public transport, especially for buses and bus stops. Firstly, the authors justify the need for air filtration in the capital of Poland, Warsaw. The average concentration level of PM10 and PM2.5 dust particles in large Polish cities is presented. In addition, it is underlined that PM2.5 dust particles are carriers for coronavirus COVID-19 and easily inhaled by humans. In the next step, the authors introduce an experimental stand used in the examination of different filtration baffles. The filtration efficiency is defined and calculated according to experimental examinations. In these experiments, an antismog cover for air-conditioning split systems, an H13 HEPA filter and a three-stage filtration baffle (active carbon + F5 filter + EPA11 filter) were taken into consideration, and the efficiency of filtration under pressure-drop conditions and the influence of moisture were ascertained. The best filter setup was thereby determined to be the three-stage filtration baffle, being the most efficient in cleaning air on account of having the smallest mass concentration of PM2.5. This indicates that three-stage filtration is the most suitable air-filtration method for public transportation in cities where air pollution is a serious concern.
Optimization of Window Design for Daylight and Thermal Comfort in Cold Climate Conditions
Authors: Arntsen Tony-Andreas , Hrynyszyn Bozena Dorota
Published: December 2021

Window design affects the overall performance of a building. It is important to include window design during the initial stages of a project since it influences the performance of daylight and thermal comfort as well as the energy demand for heating and cooling. The Norwegian building code facilitates two alternative methods for achieving a sufficient daylight, and only guidelines for adequate indoor thermal comfort. In this study, a typical Norwegian residential building was modeled to investigate whether the criteria and methods facilitate consistent and good performance through different scenario changes and furthermore, how the national regulations compare to European standards. A better insulated and more air-tight building has usually a lower annual heating demand, with only a marginal decrease in the daylight performance when the window design is unchanged. A more air-tight construction increases the risk of overheating, even in cold climates. This study confirms that a revision of the window design improves the overall performance of a building, which highlights the importance of proper window design. The pursuit of lower energy demand should not be at the expense of indoor thermal comfort considering the anticipated future weather conditions. This study indicates that criteria for thermal comfort and daylight, if clearly defined, can affect the energy demand for heating and cooling, as well as the indoor climate positively, and should be taken into account at the national level. A comparison between the national regulations and the European standards was made, and this study found that the results are not consistent.
A Hybrid Optimization Algorithm for Solving of the Unit Commitment Problem Considering Uncertainty of the Load Demand
Authors: Sayed Aml , Ebeed Mohamed , Ali Ziad M. , Abdel-Rahman Adel Bedair , Ahmed Mahrous , Abdel Aleem Shady H. E. , El-Shahat Adel , Rihan Mahmoud
Published: December 2021

Unit commitment problem (UCP) is classified as a mixed-integer, large combinatorial, high-dimensional and nonlinear optimization problem. This paper suggests solving the UCP under deterministic and stochastic load demand using a hybrid technique that includes the modified particle swarm optimization (MPSO) along with equilibrium optimizer (EO), termed as MPSO-EO. The proposed approach is tested firstly on 15 benchmark test functions, and then it is implemented to solve the UCP under two test systems. The results are basically compared to that of standard EO and previously applied optimization techniques in solving the UCP. In test system 1, the load demand is deterministic. The proposed technique is in the best three solutions for the 10-unit system with cost savings of 309.95 USD over standard EO and for the 20-unit system it shows the best results over all algorithms in comparison with cost savings of 1951.5 USD over standard EO. In test system 2, the load demand is considered stochastic, and only the 10-unit system is studied. The proposed technique outperforms the standard EO with cost savings of 40.93 USD. The simulation results demonstrate that MPSO-EO has fairly good performance for solving the UCP with significant total operating cost savings compared to standard EO compared with other reported techniques.
Stability Analysis of Grid-Forming MMC-HVDC Transmission Connected to Legacy Power Systems
Authors: Lourenço Luís F. N. , Perez Filipe , Iovine Alessio , Damm Gilney , Monaro Renato M. , Salles Maurício B. C.
Published: December 2021

The power system is going through a change in its very foundations. More and more power converters are being integrated into the electric grid to interface renewable energy resources and in high-voltage direct-current (HVDC) transmission systems. This article presents a discussion on the stability of power systems when HVDC transmission systems based on modular multilevel converters (MMC) are connected in grid-forming (GFM) mode to the legacy power system using concepts of energy functions and Lyapunov stability theory and considering aspects of the interoperability between GFM converter technologies. As a base for the stability analysis, we review the main GFM converter technologies (droop and virtual synchronous machine), highlighting their differences. Then, we present a model using the center-of-inertia formulation for a multi-machine/multi-GFM converter power system representing a close future scenario of power systems where GFM converters might adopt different technologies. To illustrate the theoretical Lyapunov-based stability analysis, simulations performed in Matlab/Simulink showed the behavior of a 12-bus test system during a frequency disturbance that originated from the sudden connection of a load. To reflect the interoperability of different GFM technologies and the power system, scenarios with one single GFM technology and a scenario with mixed technologies were investigated. For the test system considered, the frequency response with fewer oscillations and a higher frequency nadir was obtained when all GFM converters were operated as VSMs that have a higher inertial response contribution.
Deactivation Model Study of High Temperature H2S Wet-Desulfurization by Using ZnO
Authors: Hatunoglu Arda , Dell’Era Alessandro , Del Zotto Luca , Di Carlo Andrea , Ciro Erwin , Bocci Enrico
Published: December 2021

High-temperature desulfurization techniques are fundamental for the development of reliable and efficient conversion systems of low-cost fuels and biomass that answer to the nowadays environmental and energy security issues. This is particularly true for biomass gasification coupled to SOFC systems where the sulfur content has to be minimized before being fed to the SOFC. Thus, commercially available zinc oxide has been studied and characterized as a desulfurizing agent in a fixed-bed reactor at high temperatures from 400 °C to 600 °C. The sorbent material was characterized by XRD, BET, SEM, and EDS analyses before and after adsorption. The sorbent’s sorption capacity has been evaluated at different temperatures, as well as the breakthrough curves. Moreover, the kinetic parameters as the initial sorption rate constant k0, the deactivation rate constant kd, and the activation energy have been calculated using the linearized deactivation model. The best performances have been obtained at 550 °C, obtaining a sorption capacity of 5.4 g per 100 g of sorbent and a breakthrough time of 2.7 h. These results can be used to extend ZnO desulfurization techniques to a higher temperature than the ones used today (i.e., 550 °C with respect to 400 °C).
Leveraging LiDAR Intensity to Evaluate Roadway Pavement Markings
Authors: Mahlberg Justin , Cheng Yi-Ting , Bullock Darcy , Habib Ayman
Published: December 2021

The United States has over 8.8 million lane miles nationwide, which require regular maintenance and evaluations of sign retroreflectivity, pavement markings, and other pavement information. Pavement markings convey crucial information to drivers as well as connected and autonomous vehicles for lane delineations. Current means of evaluation are by human inspection or semi-automated dedicated vehicles, which often capture one to two pavement lines at a time. Mobile LiDAR is also frequently used by agencies to map signs and infrastructure as well as assess pavement conditions and drainage profiles. This paper presents a case study where over 70 miles of US-52 and US-41 in Indiana were assessed, utilizing both a mobile retroreflectometer and a LiDAR mobile mapping system. Comparing the intensity data from LiDAR data and the retroreflective readings, there was a linear correlation for right edge pavement markings with an R2 of 0.87 and for the center skip line a linear correlation with an R2 of 0.63. The p-values were 0.000 and 0.000, respectively. Although there are no published standards for using LiDAR to evaluate pavement marking retroreflectivity, these results suggest that mobile LiDAR is a viable tool for network level monitoring of retroreflectivity.
Retrieving Intangibility, Stemming Biodiversity Loss: The Case of Sacred Places in Venda, Northern South Africa
Authors: Pikirayi Innocent , Magoma Munyadziwa
Published: December 2021

Sacred sites and landscapes mirror indigenous peoples’ identity, well-being and sense of place. In Venda, northern South Africa, such places are preserved through myths and legends. Following a scoping study, which also involved engagement with indigenous communities, we reveal how human-driven destruction of biodiversity contributes towards significant losses of such heritage. Large-scale agriculture, mining and commercial plantations around Thathe forest, Lake Fundudzi and Phiphidi waterfalls are not only destroying these places, but also impoverishing indigenous peoples. This is not sustainable from the perspective of heritage conservation, survival and well-being of indigenous communities. Recognising intangible values expressed through myths and legends is necessary in heritage conservation and in addressing some of the Sustainable Development Goals (SDGs).
Facing COVID-19: Quantifying the Use of Reusable vs. Disposable Facemasks
Authors: Spennemann Dirk H. R.
Published: December 2021

Following the outbreak of the COVID-19 pandemic in March 2020, many governments have recommended or mandated the wearing of fitted face masks to limit the transmission of the virus via aerosols. The public had, in essence, two choices: single-use, disposable surgical masks and multi-use, washable cloth masks. While the use of cloth masks has been discussed, there are, at present no baseline data that establish the actual proportions of mask types worn in the public. This paper, which presents the findings of rapid walk-through surveys of shopping venues in Albury (Southern New South Wales, Australia), demonstrates that, overall, 33.6% of masks worn by the public were cloth masks.
The Nutritional Condition of the Spanish Soldier: “Spain. Nutrition Survey of the Armed Forces, a Report by the Interdepartmental Committee on Nutrition for National Defence 1958”
Authors: Fatjó Gómez Pedro , Pradas Francisco Muñoz , Nicolau Nos Roser
Published: December 2021

The study of the nutritional transition in Spain must combine sources concerning the health conditions and the nutritional profile of the population. Such an approximation to the issue is, as a rule, not possible until the two final decades of the 20th century. However, the report on the nutritional status of the Spanish army, undertaken by the American Interdepartmental Committee on Nutrition for National Defence (ICNND) in 1958, combines both approaches. The report is based on the medical examination of 10727 army drafts. First, the article contextualised the report’s sample geographically and demographically; second, it validated the variables used statistically; and third, it explored the relationship between the diseases diagnosed, the biomarkers yielded by blood and urine tests, and the diet. The main results were as follows: (a) the report confirmed that the military population under examination did not suffer from severe dietary shortcomings; (b) the sample presents a double bias, geographical (overrepresentation of southern provinces) and institutional (underrepresentation of the land forces).
Methodology of Studying Effects of Mobile Phone Radiation on Organisms: Technical Aspects
Authors: Bartosova Katerina , Neruda Marek , Vojtech Lukas
Published: December 2021

The negative influence of non-ionizing electromagnetic radiation on organisms, including humans, has been discussed widely in recent years. This paper deals with the methodology of examining possible harmful effects of mobile phone radiation, focusing on in vivo and in vitro laboratory methods of investigation and evaluation and their main problems and difficulties. Basic experimental parameters are summarized and discussed, and recent large studies are also mentioned. For the laboratory experiments, accurate setting and description of dosimetry are essential; therefore, we give recommendations for the technical parameters of the experiments, especially for a well-defined source of radiation by Software Defined Radio.
Environmental Efficiency Evaluation of China’s Power Industry Based on the Two-Stage Network Slack-Based Measure Model
Authors: Wei Wei , Ding Shuangying , Zheng Silin , Ma Jingjing , Niu Tong , Li Jinkai
Published: December 2021

How to achieve the continuous improvement of the environmental performance level of the power industry within the requirements of clean and low-carbon energy development is the fundamental requirement and inevitable choice for the construction of ecological civilization and sustainable development. From the perspective of environmental protection, based on the Data Envelopment Analysis (DEA) method and the internal mechanism of power system production and supply, the power industry environmental efficiency evaluation index system was constructed, and the two-stage Network Slack-based Measure (NSBM) model considering undesired output was used to calculate China’s 30 provinces and municipalities from 1998 to 2019. The environmental efficiency is divided into two links: power generation efficiency and transmission and distribution efficiency. The study found that, within the research interval, the overall environmental efficiency of China’s 30 provinces is low, and the differences between provinces and cities are large, but they have gradually developed in a better direction after 2015. The power generation efficiency of the first link in most provinces and municipalities is higher than the transmission and distribution efficiency of the second link, and the low transmission and distribution efficiency is an important reason for the low comprehensive level of environmental efficiency. The overall evolution trend of environmental efficiency in the six regions of China is roughly the same, but the regional differences are obvious, showing a trend of “high in the southeast and low in the northwest”. The economic and natural resource differences in different provinces and cities in each region have led to varying degrees of redundancy in five aspects, including investment in power assets, installed power generation capacity, and length of transmission lines, which seriously affect the environmental efficiency of the power industry. This research attempts to open the “black box” of the environmental efficiency conversion process of the power industry, which can provide directions and strategic suggestions for the improvement of the efficiency of the power industry in China.
Insulin Resistance Is Associated with Multiple Chemical Sensitivity in a Danish Population-Based Study—DanFunD
Authors: Bjerregaard Anne A. , Petersen Marie W. , Gormsen Lise Kirstine , Skovbjerg Sine , Jørgensen Niklas R. , Linneberg Allan , Cedeño-Laurent José G. , Jørgensen Torben , Dantoft Thomas M.
Published: December 2021

Multiple chemical sensitivity (MCS) is a multisystem syndrome, and limited knowledge of its pathophysiology exists. Based on the population-based Danish cohort DanFunD, this study investigated metabolic health in people with MCS compared to individuals who did not have MCS. From 9656 cohort participants aged 18–76 years old, 1.95% were categorized as MCS individuals with comorbid functional somatic disorders (MCS +FSD, n = 188), and 1.13% were categorized as MCS without functional somatic disorders (MCS ÷FSD, n = 109). MCS was characterized based on three criteria: the experience of symptoms upon exposure to common odors and airborne chemicals, symptoms related the central nervous systems and others organ symptoms, and significant impact on every day, social, and occupational life. The remaining study population without MCS or any other functional somatic disorders were regarded as controls. We used adjusted multiple linear regression with link-function to evaluate the associations between lipid and glucose metabolism markers and MCS. We also tested the odds ratio of metabolic syndrome in MCS. Results did not point to statistically significant associations between lipid biomarkers or metabolic syndrome and both MCS groups compared to the controls. We found that MCS individuals may be more insulin resistant and that MCS ÷ FSD may have an impaired glucose metabolism when compared to controls.
Oral, Vaginal and Anal Sexual Practices among Heterosexual Males and Females Attending a Sexual Health Clinic: A Cross-Sectional Survey in Melbourne, Australia
Authors: Phillips Tiffany R. , Constantinou Heidi , Fairley Christopher K. , Bradshaw Catriona S. , Maddaford Kate , Chen Marcus Y. , Hocking Jane S. , Chow Eric P. F.
Published: December 2021

Sex practices among heterosexuals are not well studied. We aimed to explore sexual practices among heterosexuals attending a sexual health clinic. This cross-sectional survey was conducted at Melbourne Sexual Health Centre between March and April 2019. Data were collected on kissing, oral sex (fellatio or cunnilingus), vaginal sex, anal sex and rimming in the previous 3 months. Univariable and multivariable logistic regression analyses were performed to examine the associations between engaging in anal sex and other sex practices. There were 709 participants (333 men; 376 women) who were eligible and completed the survey (response rate was 24.6%). In the past 3 months, most participants had had vaginal sex (n = 677; 95.5%), with a mean of 3.0 (standard deviation (SD): 3.9) vaginal sex partners, and half reported engaging in condomless vaginal sex in the past 3 months (n = 358; 50.1%). A total of 135 (19.0%) participants had had anal sex, with a mean of 1.3 (SD: 1.0) anal sex partners, with 63.5% (n = 94) engaging in any condomless anal sex in the past 3 months. Most participants (n = 637, 89.8%) had received oral sex in the past 3 months; this proportion did not differ by age group or gender. Women (n = 351, 93.4%) were more likely to perform oral sex than men (n = 275; 82.6% men) (p < 0.001) and to have received rimming (26.6% women vs. 12.6% men; p < 0.001). Men were more likely to have performed rimming (25.5% men vs. 9.3% women; p < 0.001). After adjusting for age, number of partners and sexual practice, anal sex was associated with being ≥35 years (adjusted odds ratio (aOR): 2.3; 95% CI: 1.2–4.2), receiving rimming (aOR: 3.8; 95% CI: 2.4–6.0) and performing rimming (aOR: 2.8; 95% CI: 1.8–4.6). Rimming and anal sex are practiced by one-fifth or more of heterosexuals. Older heterosexuals were more likely to engage in anal sex and to perform rimming. Future research should consider the benefits of testing extragenital sites where appropriate.
Assessment of Knowledge on the Prevention of Central-Line-Associated Bloodstream Infections among Intensive Care Nurses in Poland—A Prospective Multicentre Study
Authors: Dyk Danuta , Matusiak Agata , Cudak Edyta , Gutysz-Wojnicka Aleksandra , Mędrzycka-Dąbrowska Wioletta
Published: December 2021

The presence of a central venous catheter (CVC) leads to a high risk of blood infections, which are considered major causes of morbidity, mortality and high medical costs. The aim of this study was to assess the knowledge of nursing staff working in intensive care units (ICUs) regarding the prevention of central-line-associated bloodstream infections (CLABSIs). A nationwide survey was conducted among ICU nurses from August 2016 to April 2017. A modified Polish version of the questionnaire developed by Labeau et al. was used to assess the nurses’ knowledge. Of the 750 questionnaires distributed, 468 were returned. Women accounted for 95.73% of all respondents, and over 80% were university educated. Most of the nurses surveyed (85.9%) had previously received training in CVC guidelines, and thus over 82% rated their knowledge as good or very good. The guidelines introduced in hospitals were the main declared sources of information. In addition, more than half (68%) of respondents also knew the international guidelines. The knowledge of nursing staff in the study area is not sufficient. Studies show that the guidelines for the prevention of CLABSIs in ICUs should be standardized, and continuous training of personnel in this field should be provided.