bluuebunny/crossref_metadata_2025 huggingface dataset:
Screening of potential phytocompounds against Atherosclerosis by directing Liver X Receptor alpha (LXRα): A computational manoeuvre
Authors: Lokhande Kiran Bharat , Pawar Sarika Vishnu , Nawani Neelu , Wani Minal , Swamy K. Venkateswara , Ghosh Payel , Kale Arti Abhijit
Published: July 2023

Liver X receptor alpha (LXRα) is a nuclear receptor family member that is expressed in the liver, and has gained pharmacological interest for its role in the reduction of atherosclerosis, a long-term inflammatory disorder that affects the artery wall and is characterized by alterations in lipid metabolism. LXRα activators appear to be promising targets for preventing and/or treating these pathological conditions. The current work intends to perform a computational analysis of the IMPPAT database with LXRα. This comprehensive study will serve as a foundation for the investigation of novel plant-derived LXRα agonists against atherosclerosis. LXRα (PDB ID: 3IPU) was used as a target molecule for docking analysis. The docking scores of top five phytocompounds from the IMPAAT database, namely Betaxanthin, Adlumidiceine, Miraxanthin III S, Lupinisoflavone E, and p-Coumaroyl triacetic acid, ranged from - 35.88 kcal/mol to - 32.46 kcal/mol. The docking analysis was validated further by a 100 ns molecular dynamics study, which revealed fewer fluctuations in RMSD along with stable intermolecular interactions of lead phytocompounds with the targeted LXRα protein. The enrichment calculation metrics also validated the efficiency of the docking procedure. As evidenced by the MM-GBSA study, the binding free energies (ΔGbind) score up to -71.219 kcal/mol, with no violations in terms of drug likeliness and ADMET predictions, indicated the promising nature of these phytocompounds as drug candidates against atherosclerosis. These in silico studies, in particular, aid in analyzing phytocompounds roles as potential lead drugs, paving the way for in vitro and in vivo assessments for the development of novel anti-atherosclerosis drugs.
Growth of diamond in liquid metal at 1 atmosphere pressure
Authors: Gong Yan , Luo Da , Choe Myeonggi , Seong Won Kyung , Bakharev Pavel , Wang Meihui , Lee Seulyi , Shin Tae Joo , Lee Zonghoon , Ruoff Rodney S.
Published: July 2023

Natural diamonds were (and are) formed (some, billions of years ago) in the Earth’s upper mantle in metallic melts in a temperature range of 900–1400°C and at pressures of 5–6 GPa1,2; indeed, diamond is thermodynamically stable under high pressure and high temperature (HPHT) conditions as per the phase diagram of carbon3. Scientists at General Electric invented and used a HPHT apparatus in 1955 to synthesize diamonds from melted iron sulfide at about 7 GPa and 1600°C4–6. There is an existing paradigm that diamond can be grown using liquid metals only at both high pressure (typically 5–6 GPa) and high temperature (typically 1300–1600°C) where it is the stable form of carbon7. Here, we describe the growth of diamond crystals and polycrystalline diamond films with no seed particles using liquid metal but at 1 atmosphere pressure, and at 1025°C, breaking this paradigm. Diamond grew at the interface of liquid metal composed of gallium, iron, nickel, and silicon and a graphite crucible, by catalytic activation of methane and diffusion of carbon atoms in the subsurface region of the liquid metal. Raman spectroscopy with 13C-labeling proves that methane introduced into the growth chamber is the carbon source for many of the regions of newly grown diamond. The new growth diamonds were studied by Raman spectroscopy, scanning and transmission electron microscopy, X-ray diffraction, and photoluminescence. Growth of (metastable) diamond in liquid metal at moderate temperature and 1 atm pressure opens many possibilities for further basic science studies and for the scaling of this type of growth.
Inherent Characterstics of Recycled Concrete Aggregate by Limited Substitution of Cement With Ashes Like GGBS and Fly Ash Powder
Authors: vvs sarma , shaik subhan alisha , Pala Gireesh kumar , Sampangi Arun Chaitanya , thumati venkateswararao
Published: July 2023

The current study aims to estimate the strength performance of recycled aggregate concrete (RAC) applied in structural concrete by partially substituting cement with fly ash and ground granulated blast furnace slag (GGBS). The purpose of this project is to get a deeper understanding of the characteristics of RAC using GGBS and fly ash as additional cement materials. Concrete specimens containing various ratios of recycled coarse aggregate, fly ash, and GGBS are casted as part of our experiment. Analysis and comparison of the outcomes with the reference concrete mixture are performed. The results of this study will help advance sustainable concrete technology and serve as a foundation for designing RAC for structural applications that incorporates recycled coarse aggregate, fly ash, and GGBS. In our study we conducted tests like Compressive strength of concrete, split tensile strength of the concrete, Flexural strength of the concrete, recycled aggregate used partially in our study is 20%, 40%,60% and GGBS powder used partially in cement with percentages of 10,15,20 and parlay with fly ash content partially used in cement with percentages of 10,15,20. Our observation from this project is we good acceptable values combinedly at the percentages of 40% Recycled aggregate and 15 percentages of both GGBS and FA .We can have further research work by implementing the same research with wide verity range of cement materials.
Analysis of the curative effect and risk factors for recurrence of modified Sistrunk procedure on thyroglossal duct cyst in children
Authors: Zhang Ge , Li Xiaodan , Hao Jinsheng , Zhang Jie , Li Yanzhen , Zhang Xuexi , Liu Qiao , Sun Nian , Liu Zhiyong , Chen Ziwei , Liu Yuwei , Ji Tingting , Pang Wei , Wang Shengcai , Ni Xin
Published: July 2023

Objectives
The present study aimed to retrospectively summarize the optimization experience of the modified Sistrunk (mSis) procedure, analyze the curative efficacy of this procedure in the treatment of children with thyroglossal duct cyst (TGDC), and investigate the related risk factors for recurrence.
Methods
A retrospective analysis was conducted on children undergoing mSis procedure from March 2012–December 2021. Based on our practical experience, the mSis procedure has been optimized in the following details: the resection at the cartilaginous joint of hyoid bone, core out to the foramen cecum, and the resection and ligation techniques of the fistula near the foramen cecum. Medical history, physical examination characteristics, ultrasound characteristics, and prognosis were evaluated by regression analysis.
Results
Of the 391 children with TGDC, the recurrence rate was 2.30% and the recurrence time ranged from 0.5–34 (average, 7.2) months after the procedure. During the follow-up, 10 children had local wound infection but no recurrence and none had other complications. In the Poisson regression model, the p-values of the three factors of clearness of lesion boundary, surgical history, and lesion diameter were < 0.05 and the relative risk (RR) values corresponding to the above three risk factors, such as Exp (B), were 27.918, 10.054, and 6.606, respectively.
Conclusion
The present study made optimizations based on the previous mSis procedure and integrated the complete resection and less injury. Thus, the procedure was safe and effective with fewer complications and a low recurrence rate. In addition, the indistinct lesion boundary, surgical history, and large lesion diameter were independent risk factors for disease recurrence.
Level of Evidence: IV
Likely Hydrolysis of Phoenix dactylifera Cell Wall Pectin by Fusarium oxysporum Pectin Methylesterase and Endo-polygalacturonase Activity Revealed in Vitro
Authors: Cherif Brahim , Karkachi Noureddine , Yezli Wassim , Henni Jamal Eddine , Kihal Mebrouk
Published: July 2023

Fusarium oxysporum forma specialis albedinis is the causal agent of Phoenix dactylifera vascular fusariosis. It hydrolyzes the pectocellulosic wall of Phoenix dactylifera vascular tissue. Pectinases hydrolyze cell wall pectin, but they are not active in all strains, so it is not clear whether such hydrolysis is a mechanism of pathogenesis. This research tries to answer this question by testing the significance of pectin methylesterase and endo-polygalacturonase activity in hydrolyzing P. dactylifera cell wall pectin and suggests their mechanism of pathogenesis. Six F. oxysporum strains isolated from P. dactylifera of Beni Abbes and Ghardaia provinces were grown in glucose and in pectin, and the enzyme activity was measured with titrimetric methods. The activity in all strains was quantified and then compared with growth carbohydrates and provinces with statistical tests. We found that pectin methylesterase from both growth conditions hydrolyzed pectin, but endo-polygalacturonase was not active in glucose. Surprisingly, statistical tests showed that this inhibition was not caused by carbon catabolite repression. Pectin methylesterase was more active than endo-polygalacturonase in pectin and in strains isolated from P. dactylifera of Beni Abbes. We suggest that F. oxysporum inhibits endo-polygalacturonase, using an unknown mechanism. We conclude that the product of hydrolysis gradually blocks sap circulation and causes maceration of the rachis. We revealed that F. oxysporumhas a significant pectin methylesterase and endo-polygalacturonase activity, which can hydrolyze the cell wall pectin of P. dactylifera. Themaceration of date palms may be caused by these enzymes, and endo-polygalacturonase inhibition is not directly caused by glucose.
Intravascular large B-cell lymphoma (IVLBCL): Subtle Presentation and Challenging Diagnosis
Authors: Bendari Ahmed
Published: July 2023

Intravascular large B-cell lymphoma (IVLBCL) is a rare, clinically aggressive lymphoma defined by the proliferation of atypical lymphoma cells in the lumen of all sized blood vessels, particularly capillaries. The reasons for this unusual neoplastic cell proliferation are still only partially understood. IVLBCL is considered stage IV lymphoma and manifests with a variety of nonspecific signs and symptoms. Patients with IVBCL usually do not present with lymphadenopathy. The tumor cells invade the blood vessels of multiple organs such as the central nervous system, skin, lungs, kidneys, and bone marrow. Common presenting symptoms are based on the organ affected and include mental status changes and fever of unknown origin. Although immunochemotherapy has significantly improved the often-poor prognosis of this kind of lymphoma, a large percentage of patient’s relapse.
We present a 63-year-old man who had been diagnosed with high grade B cell lymphoma in the bone marrow in March 2021 and was in remission state after completing six cycles of chemotherapy. There was no abnormal FDG uptake on a post-chemotherapy PET/CT scan. Patient presented to the ER 1 year later with fever and dyspnea. The entire workup was completed and showed pancytopenia and elevated ESR. PET/CT scans revealed a widespread increase in FDG uptake in both the lungs and spleen. Lung biopsy revealed large, atypical cells only within alveolar septae and vessels that were positive for CD20 and PAX-5 and had high proliferation rate based on Ki67. The diagnosis of IVLBCL was made.
IVLBCL has a low incidence rate with non-specific clinical presentation. The diagnosis can be easily missed in both clinical, radiological and the corresponding histopathological findings. Radiological finding and CT scan are not sensitive enough and may miss the lesion. Even though the PET/CT scan is more sensitive, the definitive diagnosis of IVLBCL relies mainly on histopathology and immunohistochemistry, at which point awareness and high suspicious of this entity by the pathologist is most necessary.
Clinical Features and Radiographic Aspects of Squamous Cell Carcinoma in the Gnathic Bones
Authors: Moura Ludimila Lemes , Simpione Guilherme , Peralta-Mamani Mariela , Santos Paulo Sérgio da Silva , Rubira Cassia Maria Fischer , Rubira-Bullen Izabel Regina Fischer
Published: July 2023

This integrative review aimed to discuss the clinical features and imaging aspects of squamous cell carcinoma in the gnathic bones on panoramic radiographs and cone-beam computed tomography. The electronic search was conducted in PubMed, Embase, and Scopus using the keywords cone-beam computed tomography, panoramic radiography, dentomaxillofacial complex, and oral squamous cell carcinoma. Studies between 2012 and 2022, report imaging aspects of the oral squamous cell carcinoma in panoramic radiography and cone-beam computed tomography were selected. The initial search found 375 articles, leaving 171 after excluding duplicates. Eighteen studies met the inclusion criteria, bringing together a total of twenty cases. Swelling and pain are common clinical features. In most cases, the squamous cell carcinoma was in the mandible; the borders were poorly defined with invasive aspects; the internal structure was radiolucent/hypodense and some cases, had radiopaque flecks. The lesion causes structures destroyed like the adjacent bone, the alveolar process, border of the mandibular canal, ramus of the mandible. The image aspects raised in this review: as large areas of osteolysis interspersed with an irregular pattern of radiopaque/hyperdense flakes, with imprecise limits and invasive borders, causing significant destruction of adjacent structures, squamous cell carcinoma can be a diagnostic hypothesis. In these cases, we recommend urgency in completing the diagnosis. The panoramic radiography can provide information that leads to the suspicion of a malignant lesion, but cone-beam computed tomography provides the real dimension and repercussion of the lesion.
Perfil de Resistência de Bactérias Isoladas em Pacientes Hospitalizados Portadores de Neoplasia
Authors: Sousa Ingrid Flávia Cavalcante de , Da Silva Letícia Rayane Bezerra , Silva Iran Alves da , Oliveira Sibele Ribeiro de
Published: July 2023

Introdução: O tratamento para o câncer é geralmente agressivo para o organismo do paciente, podendo levar a uma possível internação hospitalar, e é neste ambiente, que o mesmo se torna suscetível a desenvolver processos infecciosos, principalmente por bactérias multirresistentes. Objetivo: Verificar o perfil de resistência de bactérias isoladas em pacientes hospitalizados portadores de neoplasias. Material e métodos: Estudo observacional, descritivo e transversal realizado por meio da análise de laudos de urocultura de pacientes oncológicos obtidos mediante um laboratório de análises clínicas de um hospital público no interior de Pernambuco, no período de fevereiro a junho de 2021. Resultados: O total de 34 (36,95%) das uroculturas apresentaram crescimento bacteriano, sendo mais prevalente a Escherichia coli (44,11%), seguida de Citrobacter ssp. (26,47%), Enterobacter ssp. (5,88%), Enteroco­ccus ssp. (5,88%), Staphylococcus aureus (5,88%), Staphylococcus coagulase negativa (5,88%) e Proteus vulgaris (5,88%). O perfil de resistência correspondeu ao ácido nalidíxico (70,58%), ciprofloxacina (52,94%), cefalotina (52,94%) e sulfametaxozol e trimetropina (50%), enquanto o perfil de sensibilidade foi maior para os seguintes antimicrobianos: ertapenem, imipenem, piperaciclina e tazobactam, correspondendo cada um a 97,06% de sensibilidade. Conclusões: Foi verificada uma maior presença de bactérias Gram-negativas, com destaque para Escherichia coli, além disso, a prevalência de resistência bacteriana igual ou superior a 50% dos antimicrobianos das classes da quinolonas (ácido nalidíxico e ciprofloxacina), cefalosporinas (cefalotina) e sulfonamidas (sulfametaxozol e trimetropina) foi também evidenciado.
Recent progresses on BSM and dark matter searches with CUORE
Authors: Branca Antonio
Published: July 2023

The Cryogenic Underground Observatory for Rare Events (CUORE) is the first bolometric 0\nu\beta\beta0νββ experiment to reach the one-tonne mass scale. The detector, located underground at the Laboratori Nazionali del Gran Sasso in Italy, consists of 988 TeO_22 crystals arranged in a compact cylindrical structure of 19 towers, operating at a base temperature of about 10 mK. After beginning its first physics data run in 2017, CUORE has since collected the largest amount of data ever acquired with a solid state detector and provided the most sensitive measurement of 0\nu\beta\beta0νββ decay in ^{130}130Te ever conducted. The large exposure, sharp energy resolution, segmented structure and radio-pure environment make CUORE an ideal instrument for a wide array of searches for rare events and symmetry violations. New searches for low mass dark matter, solar axions, CPT and Lorenz violations, and refined measurements of the 2\nu\beta\beta2νββ spectrum in CUORE have the potential to provide new insight and constraints on extensions to the standard model complementary to other particle physics searches. In this contribution, the recent progress on BSM and dark matter searches in CUORE are discussed.
EFFECTIVENESS OF STRUCTURED TEACHING PROGRAMME ON KNOWLEDGE REGARDING ACID PEPTIC DISEASE AND ITS PREVENTION AMONG THE INDUSTRIAL WORKERS
Authors:   Assistant Professor, School of Nursing, KIIT University, Bhubaneswar, Odisha, India, 751024., Mahapatro Subhashree , Paramita Bhoi Pragnya ,   Lecturer, School of Nursing, KIIT University, Bhubaneswar, Odisha, India, 751024., Tripathy Karisma ,   Assistant Professor, School of Nursing, KIIT University, Bhubaneswar, Odisha, India, 751024., V. Sivasankari ,   Associate Professor, School of Nursing, KIIT University, Bhubaneswar, Odisha, India, 751024.
Published: July 2023

Aim- To assess the impact of STP on knowledge regarding Acid Peptic Disease and its prevention among inductrial workers. Subject &Method: An quasi-experimental study was conducted on 66 industrial workers by using convienient sampling. A self structured questionnaire was used for data collection over a period of 4 weeks that included questions related to demographic informations and knowledge related to Acid Peptic Disease. Results: The studys findings indicate that the majority of workers (98%) had poor knowledge about acid peptic disease prevention. But after the teaching programmes on Acid Peptic Disease, most of them (88%) had good knowledge. The mean knowledge difference between pretest -post test intervention is 0.18Â±0.694 (P < 0.05). The Z test value indicated a significant change between the pretest and posttest knowledge levels (p = 0.021).This indicated that the STP was effective in raising industrial workers awareness of the prevention of acid peptic illness. Conclusion : Structured teaching programme on knowledge regarding Acid Peptic Disease and its prevention has resulted in an increment of knowledgeamong industrial workers. Nursing personnel can help the community people to prevent themselves from Acid peptic disease by creating awareness among the community people.
CSR REPORTING BY MOROCCANBANKS :AN EXPLORATORYSTUDYBASED ON THE GLOBAL REPORTING INITIATIVE
Authors:   Universite Mohammed V, Faculte des Sciences de leducation, Rabat, Maroc., Hicham Elhafdi M.
Published: July 2023

This research analyzes the extra-financial reporting of Moroccan banks, in order to explore whether they integrate CSR issues as defined by the GRI guidelines, as well as the issues specific to the financial sector listed by its sector supplement. Mobilizing content analysis techniques, we have built an analysis scenario under Tropes grouping the indicators of the above-mentioned standards. Overall, the results reveal that the quality of extra-financial disclosure is dependent on the reporting framework. They also recognize the predominance of social disclosures, and the weakness of those of an environmental nature. Finally, they suggest that improving the maturity of reporting requires greater involvement of stakeholders, and work on the reliability of non-financial information by having recourse to its external verification.
A COMPARATIVE STUDY OFLIGATION OF INTERSPHINCTERIC FISTULA TRACT AND FISTULECTOMY IN THE MANAGEMENT OF TRANS SPHINCTERIC FISTULA IN ANO
Authors:   Senior Resident Department of General Surgery, ESIC-MC & PGIMSR, Rajajinagar, Bangalore- 560010., H.T Satish , M. Shridhar ,   Director Professor & HOD Department of General Surgery, ESIC-MC & PGIMSR, Rajajinagar, Bangalore560010., B.V Nutan ,   Senior Resident Department of General Surgery, ESIC-MC & PGIMSR, Rajajinagar, Bangalore- 560010., M. Shivakumar ,   Senior Resident Department of General Surgery, ESIC-MC & PGIMSR, Rajajinagar, Bangalore- 560010.
Published: July 2023

Background: A fistulectomy involves complete excision of the fistulous tract, thereby eliminating the risk of missing secondary tracts and providing complete tissue for histopathological examination. By studying with comparing the LIFT with fistulectomy withits outcome being advantages and disadvantages in terms of hospital stay, postoperativebleeding, postoperative pain, recurrences, incontinence patient can be benefitted with early outcome with less complications associated, so this study being done to evaluate the standard procedure in terms of with less complication associated. Objectives of the study: To compare the LIFT with fistulectomy in term of operative time, postoperative, bleeding, hospital stay, wound healing, postoperative pain, recurrence, incontinence Methods: Patients satisfying inclusion criteria are enrolled within 24 hours of admission after informed consent. All the patients with Trans sphincteric fistula in ano will be evaluated with thorough clinical examination, radiological and laboratory investigations. Those who require surgery will be admitted and appropriate surgery will be performed .and analyzed for in term of operative time, postoperative bleeding, hospital stay, postoperative pain, recurrence, incontinence. Results: Majority of patients belonged to the age group of 30 -40 years. M:F is 4:1, Duration of hospital stay is significantly low in LIFT group with P<0.417, Post-operative pain is less in LIFT group with P<0.002, Post-operative woundHealing time are less with LIFT group . Incontinence is less with LIFT group when compared to Fistulectomy with P<0.0452, recurrence is noted in either group but more in LIFT group. Success rate in our study is 90% in LIFT group. Interpretation and conclusion: LIFT is associated with less postoperative pain, shorter duration of hospital stay and a quicker recovery, shorter duration of surgery, earlier return to work as compared with fistulectomy. LIFT procedure is not associated with major post-operative complications. There is no incontinence in the follow up period of six months.
COMPARATIVE STUDY OF MACHINE TRANSLATION TECHNIQUES
Authors:   Dept. of Computer Science and Engineering, Dr. Ambedkar Institute of TechnologyBangalore, Karnataka, India., B.N Brunda , Potdar Veena ,   Dept. of Computer Science and Engineering, Dr. Ambedkar Institute of TechnologyBangalore, Karnataka, India., Santhosh Lavanya ,   Dept. of Computer Science and Engineering, Dr. Ambedkar Institute of TechnologyBangalore, Karnataka, India., N. Indu ,   Dept. of Computer Science and Engineering, Dr. Ambedkar Institute of TechnologyBangalore, Karnataka, India., N.C Brunda ,   Dept. of Computer Science and Engineering, Dr. Ambedkar Institute of TechnologyBangalore, Karnataka, India.
Published: July 2023

Machine translation (MT) is an approach to give knowledge and train computer to translate the sentence from one language to another language with the same fluent and meaning. MT is evaluated by the techniques that are giving the best translating accuracy. The four major techniques are Statistical Machine Translation, Rule-based Machine Translation, Example-based Machine Translation and Neural Machine Translation. We will see comparison and evaluation between these techniques in this particular paper with the examples and BLEU scores.
BULBO-MEDULLARY EPENDYMOMA IN AN ADULT: CASE REPORT
Authors:   RadiationOncology.Department,MohamedVICenterforCancerTreatment,UHCIbnRochd,FacultyofMedicineandPharmacy,HassanIIUniversity,Casablanca, Morocco., Chekrine Tarik , Ait Alla Meriem ,   RadiationOncology.Department,MohamedVICenterforCancerTreatment,UHCIbnRochd,FacultyofMedicineandPharmacy,HassanIIUniversity,Casablanca, Morocco., Bourhafour Mouna ,   RadiationOncology.Department,MohamedVICenterforCancerTreatment,UHCIbnRochd,FacultyofMedicineandPharmacy,HassanIIUniversity,Casablanca, Morocco., Bouchbika Zineb ,   RadiationOncology.Department,MohamedVICenterforCancerTreatment,UHCIbnRochd,FacultyofMedicineandPharmacy,HassanIIUniversity,Casablanca, Morocco., Benchakroun Nadia ,   RadiationOncology.Department,MohamedVICenterforCancerTreatment,UHCIbnRochd,FacultyofMedicineandPharmacy,HassanIIUniversity,Casablanca, Morocco., Jouhadi Hassan ,   RadiationOncology.Department,MohamedVICenterforCancerTreatment,UHCIbnRochd,FacultyofMedicineandPharmacy,HassanIIUniversity,Casablanca, Morocco., Tawfiq Nezha ,   RadiationOncology.Department,MohamedVICenterforCancerTreatment,UHCIbnRochd,FacultyofMedicineandPharmacy,HassanIIUniversity,Casablanca, Morocco., Karkouri Mehdi ,   LaboratoryofAnatomopathology,UHCIbnRochd,FacultyofMedicineandPharmacy,HassanIIUniversity,Casablanca, Morocco., Lakhdar Abdelhakim ,   NeurosurgeryDepartment,UHC IbnRochd,FacultyofMedicineandPharmacy,Casablanca,Morocco., Sahraoui Souha ,   RadiationOncology.Department,MohamedVICenterforCancerTreatment,UHCIbnRochd,FacultyofMedicineandPharmacy,HassanIIUniversity,Casablanca, Morocco.
Published: July 2023

Spinal ependymoma, the most common intramedullary tumour in adults, is generally located intradurally and intramedullarily. The presence of this tumor in the bulbo-medullary region is rarely documented in the medical literature.We present the case of a 33-year-old man with persistent torticollis and severe neck pain. Spinal cord magnetic resonance imaging revealed a lesion in the bulbo-medullary region. Subtotal resection of this lesion was performed, and anatomopathological and immunohistochemical analysis confirmed the diagnosis of ependymoma. Following surgery, the patient underwent post-operative radiotherapy.The standard therapeutic management of ependymoma is total tumor resection. However, the role of post-operative radiotherapy remains to be determined, although it is recommended in cases of subtotal resection.
Videolecciones: el toque humano en una virtualidad instalada
Authors: Martinez Canto Eugenio , Baccelli Sandra , Distéfano María Laura
Published: July 2023

Este artículo explora el impacto del uso de materiales audiovisuales en los procesos de enseñanza y aprendizaje, particularmente en la asignatura Análisis Matemático A de las carreras de Ingeniería, en la Universidad Nacional de Mar del Plata (Argentina). Se presentan las distintas etapas en el diseño, elaboración e implementación de diversos recursos. Los contenidos abordados a través de estos materiales corresponden a Curvas Planas.  Como parte del proceso de uso de estos materiales se implementó la modalidad conocida como Aula Invertida, donde la actividad del estudiante tiene lugar antes y durante la clase presencial. El marco teórico utilizado para analizar los aspectos didácticos es el Enfoque Ontosemiótico. La evaluación de estos materiales y de su impacto se efectuó a través de encuestas a docentes y estudiantes. Estos últimos valoraron positivamente estos recursos y mostraron preferencia por aquellos videos con la presencia visible de un profesor explicando en lugar de presentaciones de PowerPoint con voz en off. Se extendió la implementación de este tipo de materiales hacia otros contenidos de la asignatura. De esta manera, se favorece tanto la participación activa del estudiante en su proceso de aprendizaje como un acercamiento a las preferencias de una generación nativa digital.
Departmental Resettlements of Special Settlers during the Great Patriotic War: Mechanism of Realization and Significance (Based on the Materials of North-Western Siberia)
Authors:   University of Tyumen, Ivanov A. S. , Mikhalev N. A. ,   University of Tyumen
Published: July 2023

During the Great Patriotic War, the Soviet system of labor force mobilization functioned in extreme tension. At the same time, the existence of an extensive and multi-faceted system of forced labor in the country inevitably made the GULAG an obligatory element in the mobilization process and dramatically increased the role of various categories of special contingent in the general balance of labor resources. One of the users of forced labor during the war was the fishing industry, the development of which was included in the list of state priorities by a decree of the Council of People’s Commissars of the USSR and the Central Committee of the All-Union Communist Party of Bolsheviks of January 6, 1942. The article examines the mechanisms for the implementation of forced migration for the needs of a particular department (People’s Commissariat of the Fishing Industry) and determines their significance for recipient regions as exemplified by North-Western Siberia consisting of the Khanty-Mansi and Yamal-Nenets national districts of the Omsk (since August 1944 — Tyumen) region. The article demonstrates that the implementation of government decisions led to an increase in the significance of the department and to strengthening of the role of the People’s Commissariat of the Fishing Industry in the socio- economic development of North-Western Siberia. As a result of special resettlements, North-Western Siberia acquired the characteristics of a mono-specialized territory, which was “under the care” of one department. Nevertheless, the emergence of such a mono-region did not reduce the potential for interdepartmental conflicts and did not bring about the planned indicators, thus the goal of state policy, in this part, was not achieved.
‘“Sovexportfilm” as an Actor of Ideological Influence during the Cold War
Authors:   V. I. Vernadsky Crimean Federal University, Prosolova E. V.
Published: July 2023

During the Cold War exporting films was not only a means of obtaining commercial benefits from distribution in foreign countries, but also an important instrument of ideological influence. In the USSR, the All- Union Association “Sovexportfilm” served these functions selling Soviet film products as well as purchasing foreign films. The purpose of the article is to study the methods and principles of propaganda of “Sovexportfilm” in its work with foreign states within the framework of the foreign policy pursued by the USSR. The article examines the main aspects of the organizational activities of “Sovexportfilm”, the history of the creation and reorganization of the association, the mechanisms and efficiency of its work. The specifics of the export of products to the countries of Western Europe, the USA, Latin America, the countries of Asia and Africa are determined. The article pays particular attention to a comparative analysis of the principles of conducting propaganda aimed at foreign countries employed by the USSR and the United States as far as a number of aspects are concerned, including organizational activity, production capacity, and repertoire policy. The analysis of the sources enables to trace the main stages of the development of “Sovexportfilm” as an agent of foreign policy influence, to identify the shortcomings in the system of export of film, and also to highlight the reasons for the failure of the association’s activities in the last stages of the Cold War. Based on the results of the study, the author comes to the conclusion that “Sovexportfilm”, initially possessing a powerful starting potential for promoting Soviet films abroad, due to a number of objective factors and mistakes in organization of its work by the 1980s, ceased to perform the function of spreading ideological influence through the Soviet cinema.
Delineation of groundwater potential zones and identification of artificial recharge sites in the Kinnerasani Watershed, India, using remote sensing-GIS, AHP, and Fuzzy-AHP techniques
Authors: Shekar Padala Raja , Mathew Aneesh
Published: July 2023

The sustainable management of groundwater resources is crucial for ecological diversity, human health, and economic growth. This study employs scientific concepts and advanced techniques, including the analytic hierarchy process (AHP) and Fuzzy-AHP, to identify groundwater potential zones (GWPZs). Thematic maps representing drainage density, elevation, soil, geomorphology, slope, land use and land cover, and rainfall are used to delineate the GWPZs. Both techniques are employed to assign weights to these thematic maps based on their characteristics and water potential. The study revealed that in the investigated area, 17.76 and 18.27% of the final GWPZs (AHP and Fuzzy-AHP) can be classified as having poor potential, while 72.79 and 71.07% are categorized as having moderate potential. Moreover, 9.45 and 10.69% of the final GWPZs are identified as having high potential using the AHP and Fuzzy-AHP models, respectively. Receiver operating characteristics (ROCs) analysis is employed to validate these findings, demonstrating that the Fuzzy-AHP technique achieves an accuracy of 74% in identifying GWPZs in the region. This study utilizes the best method derived from both models to identify 26 suitable locations for artificial recharge sites. The reliable findings of this research offer valuable insights into decision-makers and water users in the Kinnerasani Watershed.
Simultaneous immobilization of heavy metals and nutrient elements in contaminated sediment using a novel composite agent product
Authors: Fu Xiaori , Huo Peishu , Wang Wenji , Li Dexiao , Liu Xiaojing , Zeng Guilu , Lyu Shuguang
Published: July 2023

In this research, an innovative type of sediment resource treatment agent (SRA) was synthesized successfully, which could immobilize ammonia nitrogen (NH3-N), total phosphorus (TP), potassium (K), and simultaneously stabilize cadmium (Cd), lead (Pb), chromium (Cr), copper (Cu), nickel (Ni), and zinc (Zn) in dredged sediment. The effects of SRA dosage on stabilizing the nutrient elements and heavy metals were investigated. The results demonstrated that the increase of SRA dosage significantly enhanced the stabilization of nutrients and heavy metals. The 14-day rainwater infiltration and rainwater scouring experiments were carried out. With the simulation test of rainwater infiltration, the stabilization ratios of Cr, Cu, Ni, Pb, Zn, Cd, NH3-N, TP, and K with 2% SRA addition reached 80.8%, 76.8%, 80.3%, 77.5%, 78.0%, 72.7%, 64.3%, 73.9%, and 73.9%, respectively. Under the action of rainwater scouring, the stabilization ratios of Cr, Cu, Ni, Pb, Zn, Cd, NH3-N, TP, and K with 6.4% SRA addition reached 84.6%, 84.0%, 77.6%, 87.3%, 80.0%, 61.5%, 76.2%, 77.8%, and 91.7%, respectively. Therefore, the results demonstrate that SRA is an excellent composite material in stabilizing heavy metals while reserving the nutrients in dredged sediment, thus showing great potential in the application for dredged sediment resource treatment.
Level of disclosure in sustainability reports in accordance with the Global Reporting Initiative (GRI)
Authors: Três Pamela , Domenico Daniela Di , Três Naline
Published: July 2023

Objective: Analyze the level of disclosure in sustainability reports in accordance with the Global Reporting Initiative (GRI), through a descriptive study, with document analysis and a quantitative procedure.

 Methodology: The research population comprised all companies listed on B3 that published sustainability reports through their respective websites, in the years 2015 to 2020, the sample being composed of 103 companies.

Results: The study points out that the group of organizational profile indicators presented the highest average of disclosure with 96.34%. From another perspective, the groups of items related to market presence, safety practices, indigenous peoples' rights and marketing and labeling had the lowest disclosure rate, 26.10%. It is conclude that as there is greater complexity in the items related to indicators of sustainability reports in accordance with the GRI model, the level of disclosure by companies is reduced. Thus, the complexity of the information of certain items is related to the probability of non-disclosure.

Contributions of the study: Therefore, in this study, all indicators of greater and lesser complexity were analyzed, highlighting that as there is greater complexity and effort on the part of companies in the items related to indicators of sustainability reports in accordance with the GRI model, the a lower level of disclosure by companies. In this way, the complexity of the information of certain items is related to the probability of non-disclosure.
Influence of using the budget and heuristic biases on the professional competencies of bean counters and business partners
Authors: Wohlemberg Tiago Ramos , Villalba Veronica Ahimaras , Dal Vesco Delci Grapegia , Toigo Leandro Augusto
Published: July 2023

Objective: The objective of this research is to verify if the use of diagnostic or interactive budgets, moderated by heuristic behaviors, influences the controllers' professional competencies.

Methodology: This is a descriptive research study carried out by means of a survey with 109 individuals who work as controllers. In order to meet the research objective, in addition to diagnosing the data by counting the answers, a logistic regression model was used, chosen by means of the Wald Backward Stepwise method.

Results: The results found in the research indicate that there is predominance of competencies linked to the bean counter profile in the controllers' work functions. Regarding use of the budget, it was found that using the interactive budget to communicate goals to their work teams is characteristic of controllers whose professional competencies belong to the business partner profile and present behaviors influenced by heuristics and who, regardless of such influence, use the interactive budget for discussion of actions; whereas use of the diagnostic budget for managerial planning is characteristic of bean counters. It was also found that heuristic components are present in the controllers' behaviors, especially those of Anchoring and Availability, although it was not possible to directly link them to these individuals' professional competencies.

Contributions of the study: The theoretical contributions of the study clarify the relationship between the specific uses of diagnostic or interactive budgets influenced by heuristic behaviors and the controllers' professional competencies. The research expands the debate on the controller's role that prevails in Brazil.
Natural Plant Materials as a Source of Neuroprotective Peptides
Authors: Skibska Agnieszka , Perlikowska Renata
Published: July 2023

:

In many circumstances, some crucial elements of the neuronal defense system
fail, slowly leading to neurodegenerative diseases. Activating this natural process by administering
exogenous agents to counteract unfavourable changes seems promising.
Therefore, looking for neuroprotective therapeutics, we have to focus on compounds that
inhibit the primary mechanisms leading to neuronal injuries, e.g., apoptosis, excitotoxicity,
oxidative stress, and inflammation. Among many compounds considered neuroprotective
agents, protein hydrolysates and peptides derived from natural materials or their synthetic
analogues are good candidates. They have several advantages, such as high selectivity
and biological activity, a broad range of targets, and high safety profile. This review
aims to provide biological activities, the mechanism of action and the functional
properties of plant-derived protein hydrolysates and peptides. We focused on their significant
role in human health by affecting the nervous system and having neuroprotective
and brain-boosting properties, leading to memory and cognitive improving activities. We
hope our observation may guide the evaluation of novel peptides with potential neuroprotective
effects. Research into neuroprotective peptides may find application in different
sectors as ingredients in functional foods or pharmaceuticals to improve human health
and prevent diseases.
Novel Approaches to the Management of Diabetes Mellitus in Patients with
Coronary Artery Disease
Authors: Oikonomou Evangelos , Xenou Maria , Zakynthinos George E. , Tsaplaris Paraskevas , Lampsas Stamatios , Bletsa Evanthia , Gialamas Ioannis , Kalogeras Konstantinos , Goliopoulou Athina , Gounaridi Maria I. , Pesiridis Theodoros , Tsatsaragkou Aikaterini , Vavouranakis Manolis , Siasos Gerasimos , Tousoulis Dimitris
Published: July 2023

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in individuals with diabetes
mellitus (DM). Although benefit has been attributed to the strict control of hyperglycemia with traditional
antidiabetic treatments, novel antidiabetic medications have demonstrated cardiovascular (CV) safety and benefits
by reducing major adverse cardiac events, improving heart failure (HF), and decreasing CVD-related mortality.
Emerging data underline the interrelation between diabetes, as a metabolic disorder, and inflammation,
endothelial dysfunction, and oxidative stress in the pathogenesis of microvascular and macrovascular complications.
Conventional glucose-lowering medications demonstrate controversial CV effects. Dipeptidyl peptidase-
4 inhibitors have not only failed to prove to be beneficial in patients with coronary artery disease, but also
their safety is questionable for the treatment of patients with CVD. However, metformin, as the first-line option
for type 2 DM (T2DM), shows CVD protective properties for DM-induced atherosclerotic and macrovascular
complications. Thiazolidinedione and sulfonylureas have questionable effects, as evidence from large studies
shows a reduction in the risk of CV events and deaths, but with an increased rate of hospitalization for HF.
Moreover, several studies have revealed that insulin monotherapy for T2DM treatment increases the risk of major
CV events and deaths from HF, when compared to metformin, although it may reduce the risk of myocardial
infarction. Finally, this review aimed to summarize the mechanisms of action of novel antidiabetic drugs
acting as glucagon-like peptide-1 receptor agonists and sodium-glucose co-transporter-2 inhibitors that show favorable
effects on blood pressure, lipid levels, and inflammation, leading to reduced CVD risk in T2DM patients.
Understanding the Artemia Salina (Brine Shrimp) Test: Pharmacological
Significance and Global Impact
Authors: Olmedo Dionisio A. , Vasquez Yelkaira , Morán Juan Antonio , De León Estela Guerrero , Caballero-George Catherina , Solís Pablo N.
Published: July 2023

Background:

The microplate benchtop brine shrimp test (BST) has been widely used
for screening and bio-guided isolation of many active compounds, including natural products. Although
the interpretation given to the results appears dissimilar, our findings suggest a correlation
between positive results with a specific mechanism of action.

Objective:

This study aimed to evaluate drugs belonging to fifteen pharmacological categories having
diverse mechanisms of action and carry out a bibliometric analysis of over 700 citations related
to microwell BST.

Methods:

Test compounds were evaluated in a serial dilution on the microwell BST using healthy
nauplii of Artemia salina and after 24 hrs of exposition, the number of alive and dead nauplii was
determined, and the LC50 was estimated. A metric study regarding the citations of the BST miniaturized
method, sorted by type of documents cited, contributing country, and interpretation of results
was conducted on 706 selected citations found in Google Scholar.

Results:

Out of 206 drugs tested belonging to fifteen pharmacological categories, twenty-six
showed LC50 values <100 μM, most of them belonging to the category of antineoplastic drugs;
compounds with different therapeutical uses were found to be cytotoxic as well. A bibliometric
analysis showed 706 documents citing the miniaturized BST; 78% of them belonged to academic
laboratories from developing countries located on all continents, 63% interpreted their results as
cytotoxic activity and 35% indicated general toxicity assessment.

Conclusion:

BST is a simple, affordable, benchtop assay, capable of detecting cytotoxic drugs
with specific mechanisms of action, such as protein synthesis inhibition, antimitotic, DNA binding,
topoisomerase I inhibitors, and caspases cascade interfering drugs. The microwell BST is a technique
that is used worldwide for the bio-guided isolation of cytotoxic compounds from different
sources.
Calixarenes and their Relevance in Anticancer Drug Development
Authors: Paul Soumyajeet , Jeyaprakash Ramaiah Selladurai , Pai Aravinda , Venkatachalam Hillemane , Jayashree Bellur Srinivas
Published: July 2023

Calixarenes have always captured the attention of several researchers. They have the
ability to entrap multiple molecules and form inclusion complexes with drugs due to their unique
structure. Due to this property, they are being widely used in the development of several classes of
drugs, most notably anticancer drugs. This review attempted to summarize the potential applications
of calixarenes and its derivatives in the development of anticancer drugs, with a focus on the delivery
of drug classes such as DNA intercalators, taxanes, DNA alkylators, and topoisomerase inhibitors.
Calixarene-based macromolecular chemistry could therefore have a high potential for overcoming
the toxicity of cancer chemotherapy and achieving targeted drug delivery.
Computational Studies and Antimicrobial Activity of 1-(benzo[d]oxazol-2-
yl)-3,5-diphenylformazan Derivatives
Authors: Almehmadi Mazen , Alsaiari Ahad Amer , Allahyani Mamdouh , Alsharif Abdulaziz , Aljuaid Abdulelah , Saha Supriyo , Asif Mohammad
Published: July 2023

Background:

Due to the biological importance of the benzoxazole derivatives, some 1-
(benzo[d]oxazol-2-yl)-3,5-diphenyl-formazans 4a-f were synthesized and screened for in-silico
studies and in-vitro antibacterial activity.

Methods:

The benzo[d]oxazole-2-thiol (1) was prepared by reacting with 2-aminophenol
and carbon disulfide in the presence of alcoholic potassium hydroxide. Then 2-hydrazinylbenzo[d]
oxazole (2) was synthesized from the reaction of compound 1 with hydrazine hydrate in the presence
of alcohol. Compound 2 was reacted with aromatic aldehydes to give Schiff base, 2-(2-
benzylidene-hydrazinyl)benzo[d]oxazole derivatives 3a-f. The title compounds, formazan derivatives
4a-f, were prepared by a reaction of benzene diazonium chloride. All compounds were confirmed
by their physical data, FTIR, 1H-NMR, and 13CNMR spectral data. All the prepared title
compounds were screened for in-silico studies and in-vitro antibacterial activity on various microbial
strains.

Results:

Molecular docking against the 4URO receptor demonstrated that molecule 4c showed a
maximum dock score of (-) 8.0 kcal/mol. MD simulation data reflected the stable ligand-receptor
interaction. As per MM/PBSA analysis, the maximum free binding energy of (-) 58.831 kJ/mol
was exhibited by 4c. DFT calculation data confirmed that most of the molecules were soft molecules
with electrophilic nature.

Conclusion:

The synthesized molecules were validated using molecular docking, MD simulation,
MMPBSA analysis, and DFT calculation. Among all the molecules, 4c showed maximum activity.
The activity profile of the synthesized molecules against tested micro-organisms was found to
be 4c>4b>4a>4e>4f>4d.