bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated machine learning and multimodal data fusion for patho-phenotypic feature recognition in iPSC models of dilated cardiomyopathy
Authors: Wali Ruheen , Xu Hang , Cheruiyot Cleophas , Saleem Hafiza Nosheen , Janshoff Andreas , Habeck Michael , Ebert Antje
Published: April 2024

Integration of multiple data sources presents a challenge for accurate prediction of molecular patho-phenotypic features in automated analysis of data from human model systems. Here, we applied a machine learning-based data integration to distinguish patho-phenotypic features at the subcellular level for dilated cardiomyopathy (DCM). We employed a human induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) model of a DCM mutation in the sarcomere protein troponin T (TnT), TnT-R141W, compared to isogenic healthy (WT) control iPSC-CMs. We established a multimodal data fusion (MDF)-based analysis to integrate source datasets for Ca2+ transients, force measurements, and contractility recordings. Data were acquired for three additional layer types, single cells, cell monolayers, and 3D spheroid iPSC-CM models. For data analysis, numerical conversion as well as fusion of data from Ca2+ transients, force measurements, and contractility recordings, a non-negative blind deconvolution (NNBD)-based method was applied. Using an XGBoost algorithm, we found a high prediction accuracy for fused single cell, monolayer, and 3D spheroid iPSC-CM models (≥92 ± 0.08 %), as well as for fused Ca2+ transient, beating force, and contractility models (>96 ± 0.04 %). Integrating MDF and XGBoost provides a highly effective analysis tool for prediction of patho-phenotypic features in complex human disease models such as DCM iPSC-CMs.
Infinitely many solutions for a p(x)-triharmonic equation with Navier boundary conditions
Authors: Belakhdar Adnane , Belaouidel Hassan , Filali Mohammed , Tsouli Najib
Published: April 2024

In this work, we will study the existence of an infinity of solutions of a Navier problem governed by the

p
⁢

(
x
)

{p(x)}

-triharmonic operator using the theory of Ljusternick–Shrilemann and the theory of the variable exponent Sobolev spaces.
Effect of pH in the bismuth vanadate nanorods for their supercapacitor applications
Authors: Suganya Palani , Shankar Veerasamy Uma , Mona Yuttana , Chaichana Chatchawan , Vignesh Shanmugam , Sundramurthy Venkatesa Prabhu , Untisso Tarikayehu Amanuel , Oh Tae Hwan
Published: April 2024

The different pH-varied bismuth vanadate nanorods have been synthesized through a solvothermal method and utilized for XRD, HRTEM, SEM and electrochemical studies. The XRD spectra of BV-5 and BV-7 samples show the monoclinic structure. Both electrodes show rod-like morphology. Also, when the pH 7 the bismuth oxide shows large size nanorods compared with pH 5. The interspacing distance of the samples were reduced while the pH was increased. The electrochemical performance of the prepared BV-5 and BV-7 shows higher capacitance values of 235 and 167 F/g for BV-5 and BV-7 electrodes, also these electrodes show a maximum energy density value of 13.4 and 18.8 Wh/kg and related power density values are 720 and 867 W/kg, respectively. The power density value of the BV-7 electrode was increased without affecting the energy density value. Moreover, the cyclic retention of BV-7 shows 93 % at the 1000th cycle. Also, the capacitance and Rct values of BV-7 electrode are comparatively higher than pure BV-5 electrode.
Stereotypical Hippocampal Clustering Predicts Navigational Success in Virtualized Real-World Environments
Authors: Ozubko Jason D. , Campbell Madelyn , Verhayden Abigail , Demetri Brooke , Brady Molly , Thorp John , Brunec Iva
Published: April 2024

Structural differences along the hippocampal long axis are believed to underlie meaningful functional differences. Yet, recent data-driven parcellations of the hippocampus subdivide the hippocampus into a 10-cluster map with anterior-medial, anterior-lateral, and posteroanterior-lateral, middle, and posterior components. We tested whether task and experience could modulate this clustering using a spatial learning experiment where male and female participants were trained to virtually navigate a novel neighborhood in a Google Street View-like environment. Participants were scanned while navigating routes early in training and after a 2 week training period. Using the 10-cluster map as the ideal template, we found that participants who eventually learn the neighborhood well have hippocampal cluster maps consistent with the idealeven on their second day of learningand their cluster mappings do not deviate over the 2 week training period. However, participants who eventually learn the neighborhood poorly begin with hippocampal cluster maps inconsistent with the ideal template, though their cluster mappings may become more stereotypical after the 2 week training. Interestingly this improvement seems to be route specific: after some early improvement, when a new route is navigated, participants' hippocampal maps revert back to less stereotypical organization. We conclude that hippocampal clustering is not dependent solely on anatomical structure and instead is driven by a combination of anatomy, task, and, importantly, experience. Nonetheless, while hippocampal clustering can change with experience, efficient navigation depends on functional hippocampal activity clustering in a stereotypical manner, highlighting optimal divisions of processing along the hippocampal anterior-posterior and medial-lateral axes.
Neural Correlates of Online Action Preparation
Authors: Shahbazi Mahdiyar , Ariani Giacomo , Kashefi Mehrdad , Pruszynski J. Andrew , Diedrichsen Jörn
Published: April 2024

When performing movements in rapid succession, the brain needs to coordinate ongoing execution with the preparation of an upcoming action. Here we identify the processes and brain areas involved in this ability of online preparation. Human participants (both male and female) performed pairs of single-finger presses or three-finger chords in rapid succession, while 7T fMRI was recorded. In the overlap condition, they could prepare the second movement during the first response and in the nonoverlap condition only after the first response was completed. Despite matched perceptual and movement requirements, fMRI revealed increased brain activity in the overlap condition in regions along the intraparietal sulcus and ventral visual stream. Multivariate analyses suggested that these areas are involved in stimulus identification and action selection. In contrast, the dorsal premotor cortex, known to be involved in planning upcoming movements, showed no discernible signs of heightened activity. This observation suggests that the bottleneck during simultaneous action execution and preparation arises at the level of stimulus identification and action selection, whereas movement planning in the premotor cortex can unfold concurrently with the execution of a current action without requiring additional neural activity.
SOCIAL-POLITICAL ACTIVITY AND NATIONAL SOFIA OF VASYL STEFANYK AS THE BASIS OF STATE IDEOLOGY
Authors: Bagriy Maria
Published: April 2024

The article is dedicated to Vasyl Stefanyk, who not only wrote a bright page in the history of national literature, representing the literary process of its western region, but also significantly contributed to the formation of Ukrainian national education.The writer actively raised issues of education, social struggle, and political confrontations in his work and voiced them in the pages of contemporary periodicals, expanded his creative contacts with Ukrainian periodicals, intensified his activities as a publicist, which actually contributed to the rapid development of Ukrainian journalism. imprint of pedagogization: reflected the problems of development of the Ukrainian school, raised topical issues of national education, included works of modern authors and writers of the past, covering the heroic and patriotic theme, ie Ukrainian periodicals fulfilled its social function - to awaken the people of the region. consciousness of children, youth and adults, «enlightened» them, and so on. These works of Stefanyk were closely connected and caused by their active civil position.The article presents the term «national philosophy», which was introduced into the scientific lexicon in the 1930s by the Ukrainian sociologist, political scientist and ethnologist of Polish-Lithuanian origin O.-I. Bochkovsky. Having singled out nationalism as «pure science», O. Bochkovsky also included the philosophy of the nation, which he called «national philosophy», in the competence of the latter. It must become a «method of sociological typology and characterology» of nations. According to the scientist, the competence of national philosophy «includes the clarification of the problems of the nation from the ideological and philosophical point of view, therefore, the scientific coverage of issues such as nation and humanity, cosmopolitanism, internationalism and nationalism. Vasyl Stefanyk's socio-political achievements became more accessible to people through Ukrainian periodicals, served as a means of educating national consciousness, patriotism, love for the native land, opened a treasury of oral folk art, formed a sense of pride in belonging to the great "Russian people". This journalism even served as a didactic material for educational initiatives of Ukrainian public societies in the field of adult education.
SOCIAL AND ECONOMIC ASPECTS IN THE CREATIVE WORK OF VASYL STEFANYK
Authors: Savkiv Uliana , Sydor Halyna
Published: April 2024

The analysis of Vasyl Stefanyk's novelistic creative work from the standpoint of social and economic aspect has been presented. The influence of social and economic factors on the psychological state of peasants in the second half of the 19th – early 20th century has been revealed, the comparative analysis of social and economic situation of Ukrainians atthe present stage and during creative work of the writer has been conducted.Today, as in Vasyl Stefanyk's short stories, we are experiencing the social and economic consequences of the war, forced emigration, rapid impoverishment of the population and we do not always conduct successful attempts for overcoming social injustice.In Ukraine, there are no clear concepts and strategies for overcoming the negative trends in the national economy that exist in European countries.The solution of social and economic problems lies in the plane of reforms not only in the economy, but also in education, culture and national consciousness. Studying the works of Vasyl Stefanyk is an efficient way to comprehend the historical past and change the present.The introduction of decentralization of governance and rendering possibilities for regions to solve social and economic development problems on their own is an important step towards solving social and economic problems of the regions. At the same time, an important factor that will ensure successful decentralization at the state level is the provision of not only corresponding powers to the regions, but also financial resources.The solution of social and economic problems lies in the plane of reforms not only in the economy, but also in education, culture and national consciousness. Studying the works of Vasyl Stefanyk is an efficient way to comprehend the historical past and change the present.
FORMATION OF ORAL SPEECH SKILLS IN FUTURE PRIMARY LANGUAGE TEACHERS OF PRIMARY SCHOOL IN ENGLISH LANGUAGE CLASSES
Authors: Martyn Natalia
Published: April 2024

Today, the content of teaching foreign languages in secondary schools of Ukraine is being significantly updated, which is primarily due to the implementation of the Concept of the New Ukrainian School. Among the 10 key competences, the strategic educational document distinguishes communication in foreign languages. Thus, the formation of communicativeskills of the future primary school teacher in the system of higher education is one of the priority tasks.The aim of the article is to substantiate the communicative aspect of the formation of oral skills, training of future primary school teacher of English as a component of his language competence.The content of English language teaching of students is based on the following main characteristics: it corresponds to the actual communicative and cognitive interests of future teachers of English, reflects the real needs of the use of language as a means of communication, is as close as possible to the conditions and goals of real intercultural communication; stimulates the development of interests and positive attitude to the English language, influences their motivational sphere; based on the experience of mastering the native language; takes into account the general educational experience of students which has been acquired during the mastering of the school foreign language course, as well as other subjects(interdisciplinary links); stimulates students’ independent activity, encourages reflection on the quality of their own academic achievements and thedesire to improve them.In order to develop the skills of oral speech(speaking) in future teachers of English, the teacher, first of all needs to create preconditions for the organization of an active educational process, to prepare the appropriate educational and didactic base, to choose the optimal educational and methodological materials etc. It will be appropriate to use innovative educational technologies, for example, the use of video materials, which will significantly intensify the learning process, to increase the level of language competence of future teachers of English, to expand the range of use of methodological tools in teaching.
Determination of Multiple-target Equivalent Static Wind Load of Large-span Roof Structures based on Clustering Analysis Techniques
Authors: Huang Ming-Hui , Fu Chung-Lin , Hsu Yu-Wen , Lo Yuan-Lung
Published: April 2024

Spatial structures in modern society exhibit a city’s distinguishing features and show its strength in building technology. Large-span roof structures are mostly seen among spatial structures for various activities. Large-span roof structures are usually sensitive to wind loads due to their lightness in materials and curved geometric appearance. However, spatial structures are generally designed with many structural members, making it challenging to determine adequate load distributions for structural safety analysis. This paper intends to introduce the concept of the multiple-target equivalent static wind loads and to demonstrate how to reduce the heavy computational burden when the structural designer needs to consider multiple loading effects of the target structure. The wind tunnel test of an elliptical-shaped stadium structure with a flat roof is first conducted to show the fundamental aerodynamic characteristics. The methodologies of the background-component wind force based on the load-response-correlation (LRC) method and the resonant-component wind force based on the inertial force method are then introduced for the specification of single-target equivalent static wind loads. Finally, the clustering analysis technique is adopted to explain the concept of the multiple-target equal static wind loads. A decay index is proposed to indicate how the clustering technique improves the specification of equivalent static wind loads.
Financial Behavior of Households in the Context of Their Resilient Development
Authors: ZAIATS VIACHESLAV
Published: April 2024

The relevance of the article is related to the need to study the financial behavior of households as one of the factors of ensuring their resilient development in conditions of instability and uncertainty. In the conditions of war, the country’s financial market and the behavior of the subjects of financial relations are the epicenter of the country’s macroeconomic stability, which depends on the resilience of households to risky situations and the quality of life. The specified interrelationship will strengthen under the condition of active prejudice against poverty and state support of the population, which found itself in difficult life circumstances as a result of the war. The purpose of the article is to study the influence of financial behavior and financial instruments on the resilience of the country’s households in conditions of socio-economic instability and uncertain development prospects. The novelty of the work consists in identifying the peculiarities of the financial behavior of households, caused by the growth of wartime risks against the background of real opportunities and trends of their resilient development. The research is based on the use of various data sources and the application of a number of scientific methods (analysis, synthesis, comparison, generalization, selective observations). Modern financial behavior of households combines elements of various models — consumer, savings, investment, credit, insurance, charity, the relationships between which are transformed depending on the action of external and internal factors. In the conditions of war, the motives for forming one or another model of financial behavior of households change, in the choice of which they can be guided by the interests of preserving the status quo or increasing financial assets. The advantages of the saving behavior model of households as the most acceptable for resistance to wartime risks and threats and the transformation of labor income of the population into development investment resources are determined. Unlike most European countries, Ukraine is dominated by channels of unorganized savings of the population due to a low level of trust in banking structures, uncertainty in the future, and efforts to prevent the emergence of new financial risks. The transition to organized forms of savings of the population will ensure the resilience of economic development against the background of the stability of the financial and credit system of the state, trust in it by consumers of financial services. In this context, a sufficient level of profitability of financial instruments and financial literacy of the population are necessary. For its spread, it is necessary to achieve a sufficiently high level of income, rational consumption and possession of effective financial instruments against the background of trust in financial institutions.
Influence of blood electrolyte levels on the risk of atrial fibrillation after cardiac surgery
Authors: Tatarintseva Z. G. , Kosmacheva E. D. , Babicheva O. V.
Published: April 2024

Aim. To analyze the relationship of low blood potassium concentration before surgery with the risk of postoperative atrial fibrillation (POAF).

Material and methods. Data were collected and analyzed from patients admitted to the intensive care unit after cardiac surgery between January 2023 and June 2023. During the study period, 691 patients were operated on. Of these, 96 (13,9%) patients developed POAF, which made up group A (mean age 68,3±10,0). Control group B of patients with sinus rhythm was formed using a random generator and consisted of 96 patients with a mean age of 63,5±8,3.

Results. The median time to onset of arrhythmia was 39,0 (29,2-51,0) hours. The blood potassium concentration one hour before surgery was significantly reduced in patients who developed arrhythmia compared with the control group (p<0,001) and averaged 3,4±0,4 mmol/L. To determine the sensitivity and specificity of the association of hypokalemia with POAF, we used a confirmatory statistical method, namely constructing ROC curves (AUC 0,640 (95% confidence interval: 0,562-0,718; p<0,001)).

Conclusion. This study demonstrated the association of low preoperative blood potassium concentrations with the risk of POAF. Electrolyte concentrations alone cannot fully explain the risk of arrhythmia. However, optimizing electrolyte balance and, in particular, maintaining potassium concentrations >4,5 mmol/L may prevent the atrial fibrillation in some patients.
Lipid profile changes after the acute COVID-19 period. Sub-analysis of the International Registry "Dynamics Analysis of Comorbidities in SARS-CoV-2 Survivors" (AKTIV SARS-CoV-2)" (12-month follow-up)
Authors: Arutyunov G. P. , Tarlovskaya E. I. , Arutyunov A. G. , Polyakov D. S. , Grigorieva N. Yu. , Gubareva I. V. , Kamilova U. K. , Kim Z. F. , Kuznetsova A. S. , Kuznetsova T. Yu. , Ruzanov D. Yu. , Svarovskaya A. V. , Smirnova E. А. , Sugraliev A. B. , Frolova I. A. , Aimakhanova G. T. , Batluk T. I. , Bashkinov R. A. , Bikushova I. V. , Gordeychuk E. D. , Gubareva E. Yu. , Evdokimov D. S. , Zakirova G. A. , Loginova A. O. , Melnikov E. S. , Moiseenko N. B. , Trubnikova M. A. , Shcherbakov S. Yu.
Published: April 2024

Aim. To analyze the lipid profile changes during the acute phase of coronavirus disease 2019 (COVID-19) and within 12 months after discharge from the hospital (post-Covid period) in comparison with the lipid profile of patients before COVID-19.

Material and methods. The subanalysis of the registry was carried out as follows: clinical investigators in each of the centers included patients in the AKTIV registry selected from the database patients who met three following criteria: (1) availability of lipid profile test no more than 60 days before COVID-19; (2) availability of lipid profile test during the acute period; (3) availability of lipid profile test within 6-12 months after discharge from the hospital.

Results. In patients after COVID-19, a decrease in the levels of all lipid profile parameters in the acute COVID-19 phase and their subsequent increase were found.

In the post-COVID-19 period, 25,7% of patients experienced an increase in lipid profile parameters (increased levels of total cholesterol (TC) and/or cholesterol, low-density lipoproteins and/or triglycerides and/or cholesterol excluding high-density lipoproteins by ≥0,5 mmol/l) despite the fact that lipid-lowering therapy in these patients was at least no worse than in patients without lipid profile changes.

Multivariate analysis found that such variables as age (direct relationship), body mass index (direct relationship), estimated glomerular filtration rate in the acute phase (inverse relationship) and cholesterol level excluding high-density lipoproteins in the acute period (inverse relationship), as well as heart failure, obesity and cytokine storm in the acute COVID-19 phase are independent predictors of an increase in one or more lipid parameters by ≥0,5 mmol/l over 6-12 months of post-COVID-19 period.

Conclusion. COVID-19 likely contributes to the onset and/or progression of lipid metabolism disorders in COVID-19 survivors (Eurasian population).
Constrangimentos e incentivos financeiros para a prevenção e o controle da obesidade no estado do Rio de Janeiro, Brasil
Authors: Freitas Matheus Pereira , Burlandy Luciene , Castro Luciana Maria Cerqueira , Santos Cláudia Roberta Bocca , Teléfora Katiana dos Santos , Cruz Myrian Coelho Cunha da , Teixeira Márcia Regina Mazalotti
Published: April 2024

Resumo O estudo analisou como as inflexões político-econômicas de financiamento e de estruturação do Sistema Único de Saúde podem ter afetado as condições de implementação de ações de prevenção e controle da obesidade (PCO) na atenção primária à saúde (APS) no estado do Rio de Janeiro (ERJ) entre 2014 e 2021. Fundamentou-se em referenciais de análise de políticas, considerando contexto de implementação, antecedentes históricos, mecanismos de indução e incentivos governamentais para o desenvolvimento das ações de PCO. Baseou-se em dois projetos realizados nos 92 municípios do ERJ entre 2014 e 2018 (PPSUS-ERJ) e 2019-2021 (PEO-ERJ), pautados em análise documental, entrevistas e grupos focais com profissionais e gestores da APS. Até 2016, percebe-se os impactos positivos da estruturação da APS e dos mecanismos de indução federais. No entanto, as inflexões na expansão e no financiamento da APS contribuíram para o enfraquecimento de unidades, equipes e estratégias, além de uma retração de recursos para as ações estaduais e municipais. Entre 2016-2018, a crise política e financeira do ERJ foi potencializada pelas crises nacionais, e os contrapontos positivos desde então foram os mecanismos de indução e recursos federais que permaneceram, além das áreas técnicas da SES-ERJ e do cofinanciamento estadual.
Fatores associados ao aleitamento materno ao nascer em maternidades vinculadas à Rede Cegonha, Brasil, 2016-2017
Authors: Cunha Joice Ferreira , Gama Silvana Granado Nogueira da , Thomaz Erika Barbara Abreu Fonseca , Gomes Maria Auxiliadora de Souza Mendes , Ayres Bárbara Vasques da Silva , Silva Cosme Marcelo Furtado Passos da , Leal Maria do Carmo , Bittencourt Sonia Duarte de Azevedo
Published: April 2024

Resumo O aleitamento materno (AM) é um direito humano e deve ser iniciado desde o nascimento. A adequação das estratégias da Rede Cegonha (RC) pode contribuir na promoção do AM. O objetivo foi identificar os fatores associados ao AM na primeira e nas 24 horas de nascidos vivos a termo em maternidades vinculadas à RC. Estudo transversal com dados do segundo ciclo avaliativo 2016-2017 da RC, que abrangeu todo o Brasil. Foram obtidas razões de chance por meio de regressão logística binária segundo modelo hierarquizado, com intervalos de confiança a 95% e p-valor < 0,01. A prevalência de AM na primeira hora foi de 31%, e nas 24 horas, de 96,6%. Aumentaram as chances de AM na primeira hora: presença de acompanhante na internação, contato pele a pele, parto vaginal, assistência ao parto por enfermeira e acreditação da unidade na Iniciativa Hospital Amigo da Criança. Resultados semelhantes nas 24 horas, e associação com idade materna inferior a 20 anos. O AM na primeira hora foi menos satisfatório do que nas 24h, provavelmente pela elevada prevalência de cesariana, fator associado à menor chance de AM precoce. A capacitação dos profissionais sobre AM de forma contínua e a presença de enfermeiro obstetra no parto são recomendadas para ampliar o AM na primeira hora.
Association between sedentary behavior, diet and nutritional status in adolescents: baseline results from the LONCAAFS Study
Authors: Neta Adélia da Costa Pereira de Arruda , Farias Júnior José Cazuza de , Ferreira Flávia Emília Leite de Lima , Aznar Luis Alberto Moreno , Marchioni Dirce Maria Lobo
Published: April 2024

Abstract The aim of the present study was to analyze the relationship between time spent engaged in sedentary behaviors, type of diet, and overweight in adolescents. A cross-sectional study using data from the Longitudinal Study on Sedentary Behavior, Physical Activity, Eating Habits, and Health of Adolescents - LONCAAFS Study. A total of 1,438 adolescents (10 to 14 years old) from public schools in the city of João Pessoa, Brazil, participated in the study. To evaluate the combined effects of excessive time in sedentary behavior and consumption from two food groups: Convenience and Prudent on overweight, we performed multiple logistic regression analyses, adjusted for energy, level of physical activity, sex, and age. Excessive time in sedentary behavior increased the chance of adolescents being overweight by 37% (OR = 1.37; 95%CI: 1.04-1.80). This chance increased to 43% when the adolescents were simultaneously engaged in excessive sedentary behavior and had high consumption of the Convenience food group (OR = 1.43; 95%CI: 1.05-1.94) and increased to 39% on those who engaged in excessive sedentary behavior and had low consumption of foods from the Prudent (OR = 1.39; 95%CI: 1.04-1.84). Excessive sedentary behavior is associated with being overweight and the chance increases with the consumption of convenient foods.
Having children in cross-border contexts: late-family formation among homoparental families in Spain
Authors: Sánchez-Molina Raúl , Konvalinka Nancy Anne
Published: April 2024

Abstract Considered until recently unfit to rear children, non-heterosexual people have been excluded from forming families in most countries. Many, worldwide, demand access to family formation, claiming the same aptitudes as heterosexual people for raising children. However, when non-heterosexual singles and couples want to become parents in Spain, they must consider transnational contexts, resorting to inter-country adoption or surrogacy abroad, processes that contribute to delay their family formation. They must consider not only Spanish sociocultural conditions, but other countries’ legal restrictions regarding parents’ gender, social status, and sexual identity. These families experience great difficulty in gaining access to reproductive health services. Based on multi-site ethnographic fieldwork, this text addresses how, despite legislative changes allowing homoparental family formation in Spain, these parents must overcome complex bureaucratic processes when they decide to have children, while facing homophobic attitudes and policies in their quests to become parents.
Between choices and decisions. Genetics in homoparental families through surrogacy in Argentina
Authors: Ayala Estefania Victoria , Roca Alejandra Rosario
Published: April 2024

Abstract Comprehensive access to medically assisted reproduction procedures and techniques in Argentina has been assured by National Law No. 26,862 since 2013. This Law does not include surrogacy procedures, and the lack of specific regulation shifts practices to a paralegal setting. In this context, planned parenthood by male couples through surrogacy is performed through actions that convey demands for access rights and active State policies. For these couples, the argument is that surrogacy is the only option to have a child with a genetic bond with at least one of the two parents and recognize both filiatory bonds. This work results from field work in progress with parents from the Province of Buenos Aires running this practice in Argentina. Based on in-depth interviews, we attempted to rebuild personal experiences and analyze the meanings that the narratives construct regarding their parenting, the biological connections in establishing or defining family relationships, and the importance of genetics in constructing and maintaining affiliations.
A superação à família monogâmica é pela coletividade! Parentalidades não-monogâmicas de pessoas sexo-gênero-diversas
Authors: Santana Alef Diogo da Silva , Galdino Adriane Soares , Araújo Ednaldo Cavalcante de
Published: April 2024

Resumo Pessoas sexo-gênero-diversas e que são não-monogâmicas tensionam a cisnormatividade e a mononormatividade. Em termos científicos, há uma nebulosidade quanto aos arranjos parenterais dessas pessoas. Assim, esta etnografia objetiva compreender a percepção de pessoas sexo-gênero-diversas não-monogâmicas sobre parentalidades. O referencial teórico utilizado partiu dos estudos não-monogâmicos, amor e sexualidade das Ciências Sociais e Humanas em Saúde da Saúde Coletiva, e o metodológico da etnografia digital. O trabalho de campo ocorreu entre 2021 e 2022, em um grupo on-line do WhatsApp. A observação participante foi empregada no grupo e foram realizadas entrevistas on-line semiestruturadas. Emergiram duas categorias: a) Os nós das parentalidades não-monogâmicas e b) As parentalidades coletivas. Na primeira, se explora a importância do vínculo nas redes afetivas e expõe as barreiras desses arranjos familiares. Já na segunda, se descreve a importância do viver em comunidade, bem como o resgate à ancestralidade indígena e negra. O resgate à ancestralidade e às formas de se viver em comunidade ganham relevo à medida que se compreende a importância que estes possuem na vivência das parentalidades de pessoas sexo-gênero-diversas e que são não-monogâmicas.
When disability and homoparenting meet: the adoption of children with disability by same sex couples
Authors: Dias Francine de Souza , Moreira Martha Cristina Nunes , Santos Raul de Paiva
Published: April 2024

Abstract The present theoretical essay is based on six reports concerning same-sex couples and gay and lesbian people in order to interconnect homoparenting and the adoption of children with disabilities, through the lenses of human and social sciences in public health. The reports were interpreted in light of studies on same-sex adoption and the adoption of children with disabilities. Feminist approaches related to care and disability were also included in the interpretative perspective, operating as expressive webs of grammars of ableism. It was found that media approaches endorse the right to family formation and the adoption of children with disabilities by homoparental families, but with little critical depth on the category of disability and without highlighting support for the adoption of all adoptee profiles. Moreover, the intersections between homophobia and ableism increase discriminatory and oppressive logics, with the union of social groups considered to be “undesirable” representing a strategy of governmentality that reveals the complexity of grammars of ableism, applied to the sexual and reproductive rights of LGBTQIA+ adopters and to the fundamental rights of children and adolescents with disabilities who are available for adoption.
Violência obstétrica e LGBTQIA+fobia: o entrelaçamento de opressões e violações
Authors: Cardoso Priscila Fernanda Gonçalves , Shimizu Mariana Arissa
Published: April 2024

Resumo O sistema capitalista e cisheteropatriarcal se desenvolveu através da opressão e exploração de classe, raça e sexo no estabelecimento de relações desiguais e hierarquizadas de poder, e uma dessas opressões é o uso da violência contra os corpos considerados errantes e transgressores dentro dessa estrutura. Dentre os diversos tipos de violência, o foco deste estudo está na violência obstétrica, compreendida como uma violência patriarcal de gênero que visa a retirada de direitos, autonomia e protagonismo de mulheres e homens trans durante o período gestacional, do parto e puerpério ou em processos de abortamento. Esse artigo tem como objetivo refletir sobre a violência obstétrica e seu impacto nas homoparentalidades de mulheres lésbicas e de homens trans, pois compreende-se que a população LGBTQIA+ é uma das mais vulnerabilizadas e que está mais distante dos serviços de saúde, justamente pela violência institucional que acomete esses corpos. Dessa forma, pretende-se compreender, através de uma análise social e histórica, como os atravessamentos dessas violações sexistas e heteropatriarcais se entrelaçam e refletem na assistência à saúde dessas pessoas, gerando ainda mais formas de opressão contra essa população.
Domestic violence patterns in postpartum women who delivered during the COVID-19 pandemic
Authors: Correia Luciano Lima , Machado Márcia Maria Tavares , Vieira-Meyer Anya Pimentel Gomes Fernandes , Araújo David Augusto Batista Sá , Gomes Emanuel de Assis Bertulino Martins , Saldanha Anyelle Barroso , Rodrigues Rita de Cássia Rebouças , Gomes Yuri Valentim Carneiro , Castro Márcia Caldas
Published: April 2024

ABSTRACT Objective: To longitudinally assess domestic violence (DV) during the postpartum period, identifying types, patterns and determinants of DV, according to mothers’ reports in Fortaleza, Brazil. Methods: Data from the Iracema-COVID cohort study interviewed at home mothers who gave birth in the first wave of COVID-19, at 18 and 24 months after birth. Patterns of reported DV were classified as follows: no DV, interrupted DV, started DV and persistent DV. Adjusted multinomial logistic regressions were used to assess factors associated with persistent DV. Results: DV was reported by 19 and 24% of the mothers at 18 and 24 months postpartum, respectively, a 5 percentage points increase. Persistent DV was present in 11% of the households in the period. The most frequent forms of DV were verbal aggression, reported by 17–20% of the mothers at 18 and 24 months, respectively; drunkenness or use of drugs at home, present in 3–5% of the households; physical aggression, reported by 1.2–1.6% of the mothers. Households with two or more forms of DV increased from 2 to 12% in the period. Adjusted factors associated with persistent DV were maternal common mental disorder, family headed by the mother and head of family’s poor schooling. Food insecurity was associated with starting DV. Conclusion: Prevalence of DV was considerably high in the postpartum period. DV prevention policies should rely on improving care to women’s mental health; preventing food insecurity; and fostering the educational level of young people of both sexes.
Photovoice, pedagogia psicodramática e multiletramentos para a formação crítica de adolescentes no contexto pandêmico
Authors: Bomfim Luciene , Biondo Fabiana , Maia Iasmin
Published: April 2024

Resumo Neste trabalho, analisamos uma vivência educacional que combinou a técnica Photovoice e a Pedagogia Psicodramática, aliadas ao trabalho com linguagens na perspectiva dos multiletramentos, para a formação crítica de adolescentes. A partir de um projeto interdisciplinar, desenvolvido por meio de TDICs, buscou-se ampliar e integrar a visão dos estudantes acerca do cuidado tridimensional: eu-outro-meio ambiente. O projeto foi desenvolvido com alunos de 1º e 2º anos da educação profissional técnica de nível médio, no interior do Mato Grosso do Sul, Brasil, em 2021, durante a pandemia da Covid-19, momento em que se evidenciou ainda mais a necessidade de olhar para o “eu”, para as relações “eu-outro” e para as relações “nós-meio ambiente”. A partir dos registros fotográficos com o Photovoice , os participantes produziram textos multissemióticos utilizando a mixagem de linguagens e mídias digitais. Para este trabalho, selecionamos as etapas do projeto de ensino, o qual foi organizado em quatro fases: aquecimento inespecífico, aquecimento específico, dramatização e compartilhamento. Para efeito de análise, utilizamos a proposta dos multiletramentos e os quatro processos do conhecimento: experienciar o novo; conceitualizar com teoria; aplicar criativamente; e analisar criticamente. As análises permitiram observar o desenvolvimento de habilidades críticas acerca de questões socioambientais que impactam o cotidiano dos participantes.
EGRESSOS DO PPGE/UFAM: AUTOAVALIAÇÃO, PRODUÇÃO E DESTINOS PROFISSIONAIS (2012–2020)
Authors: Silva Camila Ferreira da , Fernandes Maria Nilvane , Garcia Fabiane Maia , Magalhães Luciano Santos
Published: April 2024

RESUMO Este artigo toma à análise a inserção profissional de egressos do Programa de Pós-Graduação em Educação (PPGE) da Universidade Federal do Amazonas (Ufam), no período 2012–2020, no bojo de um processo de autoavaliação. Por meio da revisão de literatura e do mapeamento dos destinos profissionais (trabalho com Currículo Lattes e survey), o texto retraça os processos de desenvolvimento da pós-graduação na Região Norte, sua relação com a avaliação promovida pela Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, bem como a inserção laboral dos egressos do PPGE/Ufam. Destacam-se os impactos da pós-graduação para a formação de professores e pesquisadores para a educação básica e superior e ainda os desafios enfrentados para formar e inserir mestres e doutores nessa latitude, entre os quais a manutenção do elo com os egressos e as publicações dos resultados de suas investigações. A autoavaliação, particularmente com foco no acompanhamento de egressos, portanto, permite refletir sobre os efeitos dos processos formativos desenvolvidos pelo programa com base nos resultados alcançados pelos seus ex-alunos.
O EXERCÍCIO DA SOCIOANÁLISE NA DOCÊNCIA: UMA ARTICULAÇÃO ENTRE A SOCIOLOGIA E A PESQUISA-FORMAÇÃO
Authors: Coutinho Priscila de Oliveira , Cunha Maria Amália de Almeida
Published: April 2024

RESUMO O artigo defende que a socioanálise, tida como operacionalização de recursos sociológicos para investigar a trajetória de si, quando mobilizada como ferramenta pedagógica, resulta na confluência de duas tradições das ciências sociais e da educação, a sociologia compreensiva em seus variados matizes e a pesquisa-formação. Em seguida, argumenta que a socioanálise pode colaborar para o entendimento da teia de relações sociais e elementos estruturais que beneficiam ou dificultam a permanência na universidade. Para isso, apresenta excertos de diários de afiliação de dois estudantes da disciplina Sociologia da Educação, voltada para as licenciaturas de uma universidade pública federal. Conclui que o dispositivo, inspirado na etnometodologia de Alain Coulon, oferece a possibilidade de conciliar o saber sociológico com a escuta sensível e inspirar os estudantes a mobilizarem recursos como esse em suas práticas docentes futuras.
Comparison of pre- and postoperative functional dependence in older adults submitted to hip arthroplasty
Authors: Silva Jefferson Carlos Araujo , Sousa Gabriela Martins , Cota Natália Barrel , Silva Thalita Cristinny Araujo , Oliveira Murilo Rezende , Cavalcante Tamires Barradas
Published: April 2024

Abstract Introduction Femur fractures and hip osteoarthritis affect the functional independence of older adults. Hip arthroplasty (HA) is a surgery to treat these conditions and physiotherapy can reduce functional dependence levels. Objective Compare pre- and postoperative functional dependence in older adults submitted to HA, assess the association between functional dependence and independence, and whether age is associated with greater functional dependence in these patients. Methods A quantitative cross-sectional descriptive comparative study with older adult volunteers submitted to HA evaluated before and after surgery using the Katz index and Functional Independence Measure (FIM). Comparative analysis was performed via Wilcoxon’s matched pairs test and Spearman’s correlation. Linear regression was applied to assess the influence of functional dependence on postoperative independence (p < 0.05). Results Forty-eight patients were evaluated in the pre- and postoperative stages using the Katz index, which demonstrated reduced functional dependence after HA. The FIM assessment indicated greater post-operative functional dependence, demonstrating the surgical procedure combined with early physiotherapy while patients were hospitalized promoted functional independence in older adults. Additionally, there was a directly proportional relationship between dependence level and age. Conclusion Functional dependence declined after HA, which improved independence in older adults. Functional dependence affected postoperative independence and age influenced functional dependence.
Effect of Hafnium on the Microstructure and Mechanical Property of Pt-15Ir-xHf-0.5Y Alloy
Authors: Gan Xu , Fu Li , Wang Chen , Ge Hualong , Zhang Boning , He Junjie , Mao Yong
Published: April 2024

The influence of hafnium content on the recrystallisation and aging behaviour of hot-rolled Pt-15Ir-xHf-0.5Y alloy was investigated by scanning electron microscope (SEM), electron backscatter diffraction (EBSD) and hardness tests. The results show that the alloy texture evolves from a multi-peak one biased towards rolling direction-transverse direction (RD-TD) in the hot rolling state to a multi-peak one symmetrical along the normal direction (ND) after recrystallisation annealing. The fibrous grains become equiaxial after recrystallisation annealing, increase of hafnium content refines the grains. Pt-15Ir-xHf-0.5Y alloy exhibits age-hardening behavior at the temperature range of 600~900°C, which is due to the precipitation of (Pt,Ir)5Y phase. Increasing hafnium addition effectively improves the hardness through promoting the precipitated amount of (Pt,Ir)5Y phase. However, the internal oxidation within grain boundaries is deteriorated with the high-content hafnium addition. The results of this study provide an insight into tailoring the microstructures and mechanical properties of the platinum-iridium high-temperature alloys.
Association of Integrated Proteomic and Metabolomic Modules with Risk of Kidney Disease Progression
Authors: Schlosser Pascal , Surapaneni Aditya L. , Borisov Oleg , Schmidt Insa M. , Zhou Linda , Anderson Amanda , Deo Rajat , Dubin Ruth , Ganz Peter , He Jiang , Kimmel Paul L. , Li Hongzhe , Nelson Robert G. , Porter Anna C. , Rahman Mahboob , Rincon-Choles Hernan , Shah Vallabh , Unruh Mark L. , Vasan Ramachandran S. , Zheng Zihe , Feldman Harold I. , Waikar Sushrut S. , Köttgen Anna , Rhee Eugene P. , Coresh Josef , Grams Morgan E. ,   on behalf of the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators and the CKD Biomarkers Consortium
Published: April 2024

Key Points

Integrated analysis of proteome and metabolome identifies modules associated with CKD progression and kidney failure.

Ephrin transmembrane proteins and podocyte-expressed CRIM1 and NPNT emerged as central components and warrant experimental and clinical investigation.

Background

Proteins and metabolites play crucial roles in various biological functions and are frequently interconnected through enzymatic or transport processes.

Methods

We present an integrated analysis of 4091 proteins and 630 metabolites in the Chronic Renal Insufficiency Cohort study (N=1708; average follow-up for kidney failure, 9.5 years, with 537 events). Proteins and metabolites were integrated using an unsupervised clustering method, and we assessed associations between clusters and CKD progression and kidney failure using Cox proportional hazards models. Analyses were adjusted for demographics and risk factors, including the eGFR and urine protein–creatinine ratio. Associations were identified in a discovery sample (random two thirds, n=1139) and then evaluated in a replication sample (one third, n=569).

Results

We identified 139 modules of correlated proteins and metabolites, which were represented by their principal components. Modules and principal component loadings were projected onto the replication sample, which demonstrated a consistent network structure. Two modules, representing a total of 236 proteins and 82 metabolites, were robustly associated with both CKD progression and kidney failure in both discovery and validation samples. Using gene set enrichment, several transmembrane-related terms were identified as overrepresented in these modules. Transmembrane–ephrin receptor activity displayed the largest odds (odds ratio=13.2, P value = 5.5×10−5). A module containing CRIM1 and NPNT expressed in podocytes demonstrated particularly strong associations with kidney failure (P value = 2.6×10−5).

Conclusions

This study demonstrates that integration of the proteome and metabolome can identify functions of pathophysiologic importance in kidney disease.
Spatiotemporal Landscape of Kidney Tubular Responses to Glomerular Proteinuria
Authors: Faivre Anna , Bugarski Milica , Rinaldi Anna , Sakhi Imene B. , Verissimo Thomas , Legouis David , Correia Sara , Kaminska Monika , Dalga Delal , Malpetti Daniele , Cippa Pietro E. , de Seigneux Sophie , Hall Andrew M.
Published: April 2024

Key Points

Glomerular proteinuria induces large-scale changes in gene expression along the nephron.

Increased protein uptake in the proximal tubule results in axial remodeling and injury.

Increased protein delivery to the distal tubule causes dedifferentiation of the epithelium.

Background

Large increases in glomerular protein filtration induce major changes in body homeostasis and are associated with a higher risk of kidney functional decline and cardiovascular disease. We investigated how elevated protein exposure modifies the landscape of tubular function along the entire nephron, to understand the cellular changes that mediate these important clinical phenomena.

Methods

We conducted single-nucleus RNA sequencing, functional intravital imaging, and antibody staining to spatially map transport processes along the mouse kidney tubule. We then delineated how these were altered in a transgenic mouse model of inducible glomerular proteinuria (POD-ATTAC) at 7 and 28 days.

Results

Glomerular proteinuria activated large-scale and pleiotropic changes in gene expression in all major nephron sections. Extension of protein uptake from early (S1) to later (S2) parts of the proximal tubule initially triggered dramatic expansion of a hybrid S1/2 population, followed by injury and failed repair, with the cumulative effect of loss of canonical S2 functions. Proteinuria also induced acute injury in S3. Meanwhile, overflow of luminal proteins to the distal tubule caused transcriptional convergence between specialized regions and generalized dedifferentiation.

Conclusions

Proteinuria modulated cell signaling in tubular epithelia and caused distinct patterns of remodeling and injury in a segment-specific manner.