bluuebunny/crossref_metadata_2025 huggingface dataset:
Prévalence de la co-infection tuberculose pulmonaire/VIH entre 2018-2020 dans le Centre de Diagnostic et de Traitement de la tuberculose de Damakania, République de Guinée
Authors: Kolamou Roger , Bah Boubacar Sidy Sily , Kalivogui Siba , Diallo Boubacar Moumini , Barry Alpha Arsida
Published: June 2023

Le VIH prépare très souvent le lit de la tuberculose. Ces deux maladies tuberculose-Virus Immunodéficience Humaine (TB /VIH) forment une association. L’objectif de cette étude a été d’effectuer une étude rétrospective pour la période 2018-2020 dans le but de déterminer la prévalence de la coinfection tuberculose et VIH dans la préfecture de Kindia. Au total 2701 cas de tuberculose pulmonaire ont été recensés dont 69 cas de co-infection et 244 personnes vivant avec le VIH (PVVIH) respectivement 2,55% ; 9,03%. Dans les 2701 cas présumés 714 avaient une tuberculose pulmonaire à microscopie positive (TPM+) soit 26,43%. Tous étaient diagnostiqués simultanément par bacilloscopie (tuberculose) et par immunochromatograhie (VIH). L’âge des patients variaient entre 15 et 85 ans. Mais la tranche d’âgeoù on rencontre plus de coinfectéeet ceux vivant seulement avec le VIH était celle de 25-34 ans avec respectivement 1,07% et 3,18%. La couche féminine est approximativement plus co-infectée avec 1,37% contre 1,18% pour le sexe masculin, tandis que les PVVIH, nous avons observé 4,92% pour le sexe féminin contre 4,10% pour le sexe masculin.

HIV very often prepares the bed for tuberculosis. These two tuberculosis-Human Immunodeficiency Virus (TB/HIV) diseases form an association. The objective of this study was to carry out a retrospective study for the period 2018-2020 in order to determine the prevalence of tuberculosis and HIV coinfection in the prefecture of Kindia. A total of 2701 cases of pulmonary tuberculosis were identified, including 69 cases of co-infection and 244 people living with HIV (PLHIV) respectively 2.55%; 9.03%. Of the 2701 presumed cases, 714 had microscopy-positive pulmonary tuberculosis (TPM+), i.e. 26.43%. All were diagnosed simultaneously by bacilloscopy (tuberculosis) and immunochromatography (HIV). The age of the patients varied between 15 and 85 years old. But the age group where we meet more co-infected and those living only with HIV was that of 25-34 years with respectively 1.07% and 3.18%. The female layer is approximately more co-infected with 1.37% against 1.18% for the male sex, while the PLHIV, we observed 4.92% for the female sex against 4.10% for the male sex.
Comparative analysis of the mechanical behavior of three volute forms of centrifugal pump
Authors: Belbachir Sadia , Allali Ahmed , Lousdad Abdelkader , Boucham Belhadj , Alami Ahmed
Published: June 2023

This paper presents a comparative based analysis on the mechanical behavior of three different forms of volute of volute of a centrifugal pump with a spline, a radial and a tangential type using ABAQUS Software calculation code. The result of the analysis shows that the stress concentration is localized at the volute nozzle for all the three types of forms. This founding is an interesting element as regards to the possibilities of adaptation of a pump to a particular operation. Also it is found that the tangential volute is the least stressed compared to the other two forms. The displacements are more pronounced in the case of a radial volute. These data can be exploited in order to predict the possibility of accidental rupture of this element. From another point of view this can have an indirect influence on the appearance of vibration, noise and fluctuations of pressures and speeds due to the interaction between the fixed part (volute) and the mobile part (impeller).
Global Climate Change Scale ( GCCS): Development and validation
Authors: Yilmazilmaz Veysel
Published: June 2023

Global Climate Change (GCC) is the increase in global temperature and the change in average climate values. The climate change becoming an 'emergency' that cannot be ignored anymore is called the climate crisis. There is also a need for reliable and validated scales to measure attitudes towards GCC. This study focused on university students' global climate change scale (GCCS) development and validation. In the study, a four factor scale, called Knowledge, Awareness, Perceived R isk and Responsibility, with a n explained variance of 74.51%, was developed. In addition, the general index showing the positive attitude level of high index values towards GCC was 78%, and the index values of Knowledge, Awareness, Perceived Risk and Responsibility dimensions were cal culated as 0.76, 0.83, 0.83 and 0.69, respectively.
Biochar-mediated remediation impacts on nitrogen cycling bacteria and ammonia monooxygenase activity in crude oil polluted soil
Authors: Osadebe Anwuli U. , Davis Ibiso W. , Ogugbue Chimezie J. , Okpokwasili Gideon C.
Published: June 2023

This study adopted an ecosystem services approach to pollution management by investigating the impact of biochar-mediated remediation on soil nitrogen, abundance of nitrogen cycling bacteria and the activity of ammonia monooxygenase (AMO) enzyme in petroleum-polluted soil using two biochar types applied at two treatment levels with monitoring over 15 weeks. The corn cob-derived biochar (CDB), generally, had a stronger restorative effect on soil ammonium nitrogen, nitrate and total organic nitrogen concentrations than the bone-derived biochar (BDB). Both biochar types had a more robust impact on restoration of Nitrosomonas, Nitrobacter and Azotobacter abundance (with the re-establishment of pre-pollution levels) than on Rhizobium and Pseudomonas aeruginosa. Biochar amendment restored the activity of AMO enzyme in the soil by week 15. The CDB (72.4% – 73.7%) showed more effective total petroleum hydrocarbon (TPH) elimination capacity than the BDB (51.1% – 57.7%). Biochar amendments exhibited great potential for restoration of nitrogen cycling while facilitating remediation of petroleum-polluted soils.
N,N-Dimethylaniline as corrosion inhibitor for zinc in sulphuric acid medium
Authors: Vashi R. T. , Zele S. A. , Patel B. B. , Prajapati Neha I
Published: June 2023

The inhibitive effect of N, N-Dimethylaniline (DMA) as corrosion inhibitor for zinc in 0.1, 0.3 and 0.5 M H2SO4 solutions has been investigated by using weight loss, potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) techniques. The results obtained reveal that inhibition efficiency (I.E.) increases with increase in concentration of inhibitors but decreases with increase in temperature. As inhibitor concentration increases corrosion rate decreases. The rate constant ‘k’ decreases while half-life ‘t½’ increases with the increase in concentration of inhibitor. DMA showed maximum I. E. of 93.51 % at 60 mM in 0.5 M H2SO4 acid at 301 K. The inhibition effect is discussed in view of DMA molecules adsorbed on the metal surface and it obeys Langmuir adsorption isotherm. Polarization curve indicates that inhibitor act as mixed type for zinc corrosion in sulphuric acid solutions.
Experimental study of the flow of viscous Newtonian fluids in a centrifugal pump
Authors: Youcefi Sarra , Youcefi Abdelkader
Published: June 2023

This paper analyzes the influence of viscosity and impeller rotation speed in the calculation of the flow and in the theoretical prediction of the performance of a centrifugal pump impeller. The evaluation of the viscous effects allows the prediction of the frictional losses of the impeller and a more correct evaluation of the operating characteristics than can be obtained with a perfect fluid. The viscosity modifies the values of the velocity distribution in the channels of the impeller and the deviation of the flow at the exit of the blade. The experiments were carried out with mineral oils of different viscosities varying between 96.10-3 Pa.s and 520.10-3 Pa.s and which are represented by a perfectly newtonian behavior.
The geography of Covid-19 in Algeria: In search of demographical parameters of vulnerability
Authors: Mazri-Benarioua M. , Chettah S.
Published: June 2023

The pandemic spread of Covid-19 is worth examining by the geographic eye in order to highlight the spatial dimension of this propagation. The geographical approach is mainly convened to observe some of the territorializing aspects of coronavirus, through which it becomes possible to define the territorial specificities that intervene as vectors of vulnerability to the pandemic.

Claiming to be one of the first geographical researches on Covid-19 in Algeria, this article proposes to question the correlated relationship between its propagation dynamics and the spatial and demographic characteristics of pandemic territories. The objective is to understand the behaviors of vulnerability or resistance of these territories, via geographical parameters. Such an understanding is principally useful in health prevention and action strategies.
3-d modelling of electrical parameters’ effects on the heating of the base of an intense light illuminated polycrystalline silicon PV cell
Authors: Soro B. , Savadogo M. , Zouma B. , Tchedre K. E. , Sourabie I. , Zerbo I. , Zoungrana M. , Bathiebo D. J.
Published: June 2023

Performances of a solar cell are significantly influenced by the heating of the base. Two phenomena contribute to the heating of the base of a PV cell: the heat due to the transfer by conduction of the solar energy radiation received by the surface of the PV cell and the heat generated inside the solar cell by various phenomena related to the movement of photogenerated electrons and holes.

Thus, even if the increase of the quantity of carriers leads to improve the PV cell electrical parameters, this phenomenon also leads to the increase of some internal phenomena like thermalization, carriers braking and the carriers collisions which are sources of heating of the base of the solar cell

Indeed, electrical parameters (photocurrent, photovoltage, electric power) are physical quantities related to the movement of charge carriers and also to the illumination mode, this means that changing of electrical parameters during the operation of the PV cell leads to a variation of the temperature inside the base of the PV cell.

This work presents the effects of the increase of some electrical parameters (photocurrent, photovoltage, electric power) on the behaviour of the temperature of the base of a silicon PV cell under intense light illumination.
Thermo-mechanical properties of bio-insulation from embedding bird eggshell into ceramics for bioengineering applications
Authors: Selarak P. , Shamunee P. , Tangboriboon N.
Published: June 2023

Incorporating bird eggshell in porcelain can improve its physical, thermal, and mechanical properties, resulting in dense porcelain products. Calcium carbonate (CaCO3) from eggshells can react with silica (SiO2) and alumina (Al2O3) in porcelain clay to form calcium feldspar or anorthite (CaAl2Si2O8), which lowers the sintering temperature to <1000 °C. In this study, 0, 5, 10, 15, and 20 vol.% bird eggshell powder was added to porcelain slips and fired at 600, 700, 800, and 900 °C for 1, 3, and 5 h. The best formula of porcelain product having good mechanical and thermal properties was obtained at 10 vol.% quail eggshell-added porcelain fired for 5 h at 900 °C. The obtained sample demonstrated a relatively low thermal expansion coefficient (1.0515x10-6 °C-1), high compressive strength (6200 N mm-2), and high hardness (12.2 ± 0.30 HV).
Composition and structure of water birds in some areas of northwestern Algeria
Authors: Adamou-Djerbaoui M. , Latab H. , Dahmani W. , Omar S. , Bouacha M.I.
Published: June 2023

Wetlands have an inestimable importance in different regions of the world. Algeria is rich in wetlands which are among the most precious resources in  terms of biological diversity. Water birds are particularly attractive and important because of their long-distance migrations and their potential as  indicators of the status and value of wetlands. This is how; works on the avifauna are still more and rarer, in Algeria and particularly in the area of Tiaret. It’s, with this in mind, that our study, which relates to the assessment of the biodiversity of birds in the wetlands of Tiaret area and Tissemsilt area, over a  period of two years, from 2016 to 2018, and this in order to inventory and determine the distribution of all species of birds, photographed or captured  and recognize species of ecological, trophic and phenological interest, located in these regions which remains still virgin.
Characteristics of hydraulic jump on rough minor bed in a rectangular compound channel
Authors: Djamaa W. , Lacheheb S. , Ghomri A.
Published: June 2023

A hydraulic jump is a characteristic phenomenon in open channel flow, downstream of block ramps or rock chutes a hydraulic jump can occur over a  rough bed with great energy dissipation. This paper analyses the hydraulic jump that occurs in homogeneous rough minor beds in rectangular  compound channels. the parameters that influence the length of the jump were systematically investigated [24]. the analyses of the phenomenon were  conducted using the general jump equation. the experimental data were elaborated in order to supply a new formulation of the general jump equation  that accounts for the minor bed roughness. New formulas that satisfactorily agree with the experimental data are proposed. The results showed that  rough beds can be used to dissipate the excess hydraulic jump energy instilling basins.
Apigenin-7-glucoside induces apoptosis and ROS accumulation in lung cancer cells, and inhibits PI3K/Akt/mTOR pathway
Authors: Chen Chen , Zhong Sheng , Wu Hua , Ge Jintong , Wang Qi
Published: June 2023

Purpose: To investigate how apigenin-7-glucoside (AGL) affects the proliferation, migration, invasion, and reactive oxygen species (ROS) accumulation in  lung cancer cells, and to evaluate the potential of AGL as a therapeutic target.

Methods: Human bronchial epithelial cells (BEAS-2B), human lung carcinoma (A549), and non-small cell lung cancer cells (H1975), were treated with 25,  50, 100, and 200 μM AGL. Cell viability curves and EdU assays were used to evaluate their proliferation, while apoptosis was assessed by flow cytometry. Cell migration and invasion were evaluated by Transwell assays, and western blot was performed to determine the expression level of cytochrome C and  phosphorylation of PI3K, AKT, and mTOR. Furthermore, ELISA was used to quantify the level of malondialdehyde (MDA) and glutathione (GSH). Indirect  immunofluorescent assay (IFA) was performed by staining with DCFH-DA to evaluate ROS level.

Results: Proliferation of A549 and H1975 cells was suppressed by AGL in a dose-dependent manner. AGL significantly reduced proliferation, promoted cell  apoptosis, and attenuated the migration and invasion of A549 or H1975 cells. It also elevated the levels of cytochrome C and MDA but reduced the production of GSH in A549 and H1975 cells. AGL enhanced the accumulation of ROS and weakened phosphorylation of AKT, PI3K, and mTOR in A549 and  H1975 cells.

Conclusion: AGL represses proliferation, promotes apoptosis, suppresses migration and invasion, and induces ROS accumulation in lung  cancer cells by repressing PI3K/Akt/mTOR pathway, thus indicating the potential of AGL as a target in lung cancer treatment.
Effect of simvastatin on brain-derived neurotrophic factor (BDNF)/TrkB pathway in hippocampus of autism rat model
Authors: Chen Yingrui , Cai Linqian , Xu Yuxian
Published: June 2023

Purpose: To study the effect of simvastatin on behavioral performance in a rat model of autism, and its effect on hippocampal brain-derived BDNF-TrkB pathway.

Methods: Twelve rats with valproic acid (VPA)-induced autism were randomly divided into model group and simvastatin group, while six healthy rats  served as normal control group. Rats in the simvastatin group received the drug (5 mg/kg) via i.p. route, while rats in model group and normal control  group were injected with equivalent volume of normal saline in place of simvastatin. Capacity for interaction and repetitive stereotyped behavior, as well  as results of Morris water maze test were determined for each group. The expressions of BDNF-TrkB proteins were assayed with immunoblotting.

Results: The frequencies of sniffing normal saline, alcohol and rat urine were significantly higher in model and simvastatin rats than in normal rats, but  they were significantly lower in simvastatin-treated rats than in model rats (p < 0.05). There was higher duration of turning, jumping and grooming in the model group and simvastatin group than in the normal rats, but the duration was significantly reduced in simvastatin rats, relative to model rats. Escape  latency times was significantly longer in model and simvastatin rats than in controls, but number of target quadrant crossings was significantly reduced. However, escape latency time was lower in simvastatin rats than in model rats, but number of target quadrant crossings was significantly higher. The  model and simvastatin rats had down-regulated levels of BDNF and TrkB protein, relative to control rats, but there were markedly higher levels of these proteins in simvastatin-treated rats than in model rats.

Conclusion: Simvastatin improves the behavioral performance of autistic rats by regulating BDNF/TrkB signal axis. This finding may be useful in the  development of new drugs for treating autism.
Antimalarial activity of Mangifera indica aqueous extract in Plasmodium berghei’s apicoplast
Authors: Asanga Edet E. , Okoroiwu Henshaw , Edet Uwem O. , Amaechi Dennis , Nelson Promise E. , Uchenwa Mercy , Eseyin Olorunfemi A. , Samuel Goodnews , Ettah Lordswill A. , Obongha Osuake A.
Published: June 2023

Purpose: To investigate the in vivo antiplasmodial effect of Mangifera indica aqueous extract in Plasmodium berghei-infected mice, and to characterize  its phytochemical constituents and their mechanism of action.

Methods: The plant leaves (250.71 g) and stem bark (509.34 g) were weighed, macerated in 5 L of boiled, distilled water for 72 h, and filtered. In vivo  antiplasmodial evaluation of the extract was carried out using Plasmodium berghei-infected mice. The leaf and stem bark extracts were subjected to gas chromatography-mass spectroscopy (GC-MS) analysis for characterization of their chemical constituents.

Results: The leaf/stem bark (1:2) extract (88.27 %) exhibited chemosuppressive activities that was better than artesunate (88.04 %) and artemisinin-based  combination therapy (ACT, 84.60 %). Its schizonticidal activities (98.63 %) revealed a better therapeutic response when compared with artesunate (92.34  %). Spectroscopic analysis showed linoleic acid esters and other compounds.

Conclusion: Therapeutic response of leaf/stem bark (1:2) extract exhibit  superior schizonticidal activity to ACT and artesunate. Furthermore, the linoleic acid esters in Mangifera indica aqueous extract may contribute to strong  antimalarial activity by inhibiting fatty acid biosynthesis.
Chaihu-Longgu-Muli Decoction promotes sleep in mice with insomnia
Authors: Wang Pei , Xin Siyuan , Wang Zheng , Yu Man , Wang Jiao , Li Jinfeng , Li Min
Published: June 2023

Purpose: To determine the hypnotic and sedative effects, and the mechanism of action of ChaihuLonggu-Muli Decoction (CLMD) in mice with insomnia.

Methods: A mice model induced with insomnia using p-chlorophenylalanine (PCPA), was established. The sedative and hypnotic effects of CLMD on mice  were evaluated by animal behavioral tests. The animals were separated into four experimental groups: (1) control group, (2) PCPA group, (3) PCPA + 5 mg/kg CLMD group, and (4) CPA + 10 mg/kg CLMD group. The 5-HTR1A expression was determined by western blot. The expression levels of the  neurotransmitters were assessed using commercial ELISA kits, while the histological changes in hypothalamic tissues were examined microscopically  after staining with hematoxylin and eosin (H & E).

Results: CLMD exerted a sedative effect on and ameliorated anxiety-like and stressful behaviors in mice with insomnia. Moreover, CLMD induced sleep  and enhanced 5-HTR1A to modulate neurotransmitter secretion. The data also indicate that CLMD exerted a protective role by alleviating hypothalamic  damage and regulating the activation of NLRP3 inflammasome associated with insomnia.

Conclusion: These findings indicate that CLMD has sedative  and hypnotic effects, and offers a new therapeutic modality for insomnia treatment.
Effectiveness of nab-paclitaxel versus traditional paclitaxels in the treatment of ovarian cancer
Authors: Ding Jing , Xu Wei , Cheng Xiao-yan , Chen Xi-hai , Zhou Wen-jun , Ma Rong , Meng Fan-ling
Published: June 2023

Purpose: To evaluate the effect of four taxane drugs, namely, paclitaxel, docetaxel, paclitaxel liposomes (Lipusu), and nab-paclitaxel (Keaili) on ovarian  cancer cells both in vivo and in vitro.

Methods: BALB/c-nu/nu female mice were used to develop mouse xenograft models. The mice were randomized to 5 groups (4 in each group), namely,  control (PBS) group, paclitaxel group, docetaxel group, liposomal paclitaxel group and nab-paclitaxel group. The effect of four taxane drugs were determined via cell proliferation and toxicity tests. Mouse xenograft models were employed to assess the efficacy of four taxane drugs in inhibiting tumor  growth.

Results: Nab-paclitaxel has a significant ovarian growth-reducing effect in vitro. In vivo, no significant differences were observed in tumor volume among  the four groups (p < 0.05). Nab-paclitaxel produced the lowest animal toxicity when compared with other three drugs as the mice in nab- paclitaxel treatment group showed no significant alterations in body weight (p < 0.05). Hematoxylin and eosin (H & E) staining revealed the lowest degree  of liver tissue damage in mice treated with nab-paclitaxel compared to mice administered the other three paclitaxels.

Conclusion: Nab-paclitaxel is more effective in mice with ovarian cancer than traditional paclitaxels. Thus, it promises to offer a viable alternative as first- line chemotherapy for epithelial ovarian cancer in humans, as it has low systemic toxicity and fewer hypersensitivity reactions. However, further investigations, including clinical trials in humans, are required.
Efficacy of combined PD-1 immune therapy and chemotherapy in the treatment of locally advanced nonsmall cell lung cancer
Authors: Li Yongjie , Fu Dunzhi , Li Biao , Zhou Yuan , Li Fan , Wang Qiongyu , Huang Jialei
Published: June 2023

Purpose: To investigate the clinical efficacy of anti-programmed cell death-1 (PD-1) immunotherapy in combination with chemotherapy in patients  suffering from locally advanced non-small cell lung cancer (NSCLC).

Methods: A total of 110 NSCLC patients admitted in The Second Affiliated Hospital of Hainan Medical University, Haikou, China were randomly divided  into two groups using envelope method. The control group was administered pemetrexed and cisplatin, and the study group was further treated with nivolumab. Each treatment cycle lasted for 21 days, and a total of 6 cycles were administered for the duration of therapy. The short-term objective  response rate, adverse reactions, programmed cell death5 (PDCD-5), tumor necrosis factor-α (TNF-α), tumor necrosis factor-β1 (TGF-β1), and immune  status indices were determined.

Results: The objective remission rate in study group was 79.25 % (42/53), which was higher than that in control group (61.40 %, 35/57; p < 0.05). After  treatment, both groups showed higher levels of PDCD5 and TNF-α compared to their pre-treatment values, while demonstrating lower levels of TGF-β1. Furthermore, PDCD-5 and TNF-α in study group were higher than those in control group, while TGF-β1 was lower than that in control group (p < 0.05). In  control group, the values of clusters of differentiation 3+(CD3+), 4+(CD4+), and 8+(CD8+) decreased after treatment, while the values of CD8+ increased after treatment. The CD3+, CD4+, and CD4+/CD8+ in study group were higher than those in control group, while CD8+ was lower than those in control  group (p < 0.05).

Conclusion: Anti-PD-1 immunotherapy combination with chemotherapy in the treatment of local NSCLC stabilizes the immune system  and improves the short-term efficacy of patients with advanced NSCLC. Further clinical trials are, however, required prior to application of this  combination clinical practice.
Synaptopodin 2 represses cervical cancer cell growth and enhances the sensitivity of cervical cancer cells to cisplatin via Hippo pathway
Authors: Chen Yuanhang , He Lang , Xu Yi , Feng Qianqian
Published: June 2023

Purpose: To explore the functions and regulatory mechanisms of synaptopodin-2 (SYNPO2) in cervical cancer progression.

Methods: Normal cervical cell lines (Ect1/E6E7) and cervical cancer cell lines (HeLa, SiHa, C-33A, and CaSki) were cultured. The pcDNA3.1 vector  overexpressing SYNPO2, a negative control (vector), and blank control (control) were transfected into HeLa and SiHa cells. Protein expression from  normal and cervical cancer cell lines was examined by western blot. Cell viability and proliferation were evaluated in HeLa and SiHa cells using Cell  Counting Kit-8 and colony formation assays, while cell migration and invasion were assessed by wound healing and Transwell assays, respectively. Cell  apoptosis was determined by flow cytometry.

Results: SYNPO2 expression was decreased in cervical cancer based on the Gene Expression Profiling Interactive Analysis website (p < 0.05). Additionally,  Kaplan–Meier Plotter website showed that cervical cancer patients with low SYNPO2 expression showed worse prognoses than patients with high SYNPO2 expression (p < 0.05). Subsequent investigations revealed that SYNPO2 overexpression repressed cell proliferation, migration, and invasion in  cervical cancer (p < 0.01). Furthermore, SYNPO2 overexpression enhanced cervical cancer cell apoptosis (p < 0.001) and increased the sensitivity of cervical cancer cells to cisplatin (p < 0.01). The regulatory function of SYNPO2 on Hippo pathway in cervical cancer indicate that SYNPO2 inactivated Hippo  pathway (p < 0.05).

Conclusion: Synaptopodin 2 represses cervical cancer cell growth and enhances the sensitivity of cervical cancer cells to  cisplatin via Hippo pathway, thus indicating its potentials for development for the treatment of cervical cancer.
Effectiveness of combined use of sodium bicarbonate sitz bath prescription and vaginal nystatin suppository in the treatment of patients with fungal vaginitis
Authors: Tao Zehong , Ye Aihua
Published: June 2023

Purpose: To investigate the clinical effect of a combination of sodium bicarbonate sitz bath prescription and vaginal nystatin suppository in the treatment of patients with fungal vaginitis.

Methods: Ninety patients with mycotic vaginitis admitted to Tianchang Hospital of Traditional Chinese Medicine from April 2018 to April 2019 were selected and divided into control group (vaginal sitz bath with 5 % sodium bicarbonate solution, n = 45) and study group (vaginal nystatin suppository in addition to vaginal sitz bath with 5 % sodium bicarbonate solution, n = 45) based on the order of admission. The therapeutic effectiveness of the two treatments was compared with respect to time of relief of various clinical indicators, incidence of adverse reactions, rate of recurrence after 3 and 6 months of drug withdrawal, and vaginal pH.

Results: The time taken to relieve itching was longer in the control group (5.21 ± 2.12 days) than in the study group (3.74 ± 2.03 days; p <0 .05). There was a higher recurrence rate of itching in the control group after drug withdrawal for 3 and 6 months than in the study group (p < 0.05). Total treatment effectiveness was significantly higher in the study group than in the control group (p <0 .05). However, the incidence of adverse reactions was comparable in the two groups (p > 0.05). Vaginal pH significantly improved (less acidic) in the study group, when compared to the control group (p < 0.05).

Conclusion: Application of a combination of vaginal sitz bath using 5 % sodium bicarbonate solution and vaginal nystatin suppository is effective in the treatment of fungal vaginitis. The combination produces a favorable vaginal pH environment and low recurrence of infection. However, the combined treatment should be subjected to further clinical trials prior to application in clinical practice.
Satisfaction and quality of life of patients treated with tobramycin-dexamethasone suspension in daytime surgery managed by integrated nursing model
Authors: Yu Bo , Qiao Lingfei , Meng Yang , Li Ying , Shi Chunsheng
Published: June 2023

Purpose: To investigate the effect of an integrated nursing model in day surgeries, treated with tobramycin-dexamethasone suspension, and its influence on patient satisfaction, quality of life, and indicators of immunity recovery.

Methods: Ninety-eight patients with ophthalmic diseases admitted to Anhui No. 2 Provincial People’s Hospital, Anhui, China from January 2021 to June  2022 were scheduled for surgery and treated with tobramycin-dexamethasone. They were randomly divided into two groups (control and study groups, with 49 cases in each group). All patients received routine nursing intervention, and an integrated nursing model was applied to the study group on this  basis. Improvement in ocular symptoms, SF-36, changes in immune-related lymphocyte subsets in peripheral blood, and nursing satisfaction were compared.

Results: Ocular symptom score at 24 h after operation in the study group was lower than in control group (p < 0.05). The SF-36 scores (physical status,  cognitive ability, social function, emotional and mental status), immune-related lymphocyte subsets, and overall satisfaction rate after intervention in the study group were higher than those in the control group (p < 0.05).

Conclusion: Integrated nursing model achieves ideal nursing effect in day surgery  managed with tobramycin-dexamethasone> It also facilitates the recovery of patient’s eyes and plays a significant role in improving the quality of life,  restoration of immunity, and nursing satisfaction of patients. A multicenter investigation will, however, be required prior to its full-scale clinical  application.
The role of metformin in the management of endometriosis: A systematic review and meta-analysis
Authors: Zhang Heling , Liu Fang , Huang Yanzhen , Liu Wei
Published: June 2023

Purpose: To analyze the activity of metformin in endometriosis, with a view to alleviating disease progression.

Methods: A search was conducted using electronic databases such as CNKI, VIP, CBM, WANFANG, Embase, PubMed, Cochrane, and Web of Science from  January 1980 to January 2022 for randomized trials involving any intrapartum fetal surveillance method. A network meta-analysis was performed within  a frequentist framework, and it was assessed for quality and network inconsistency of the trials. A ninety-five percent confidence interval (CI) was used to  report the relationship between metformin levels and patients with endometriosis.

Results: Eight eligible studies which included 688 patients were evaluated in this meta-analysis. The primary indicators were treatment efficiency and  CA-125 level. Metformin significantly increased treatment efficiency (SMD = 3.29, 95 % CI 2.01, 5.40, p < 0.00001). As expected, metformin also reduced  the CA-125 level in endometriosis patients as a result (Odds Ratio, OR = -1.20, 95 % CI: -1.40 - 1.00, p < 0.00001).

Conclusion: Metformin alleviates pains caused by endometriosis. However, some studies had scanty information about alleviating clinical symptoms  other than basic medical research. More randomized controlled trials are needed to confirm treatment efficacy.
CircRTN4 inhibits the progression of gastric cancer by sponging miR-424-5p and regulating LATS2 expression
Authors: Li Xiaoli , Wang Tianming , Chen Qian , Fu Qi , Cui Yan , Pan Haibang
Published: June 2023

Purpose: To determine the expression of circRTN4 in gastric cancer (GC) and its role in tumor progression.

Methods: GEO dataset GSE93541 was analyzed using GEO2R. Starbase website was used to predict the combination of miRNA and circRTN4. The relationship between circRTN4 and prognosis was analyzed using Kaplan-Meier Plotter database, while expression levels of circRTN4, miR-424-5p, and LATS2 were assessed by quantitative real time-polymerase chain reaction (qRT-PCR). CCK8, EDU, Transwell, and Western blot were used to assess GC  proliferation, migration, invasion, and stemness. Lastly, co-transfection of miR-424-5p or si-LAST2 was reversely used to demonstrate the regulatory effect  of circRTN4 on the progression of gastric cancer cells. Significantly downregulated circRTN4 in GC was screened, and the combined miR-424-5p  and downstream gene LATS2 were predicted by Starbase.

Results: The average relative expression of circRTN4 mRNA in GC tissues was significantly lower than in adjacent tissues. MiR-424-5p was highly  expressed in tumor tissues, while LATS2 decreased (p < 0.05). Low expression of circRTN4 was associated with a low survival rate in patients. pLCDH- circRTN4 significantly inhibited the proliferation of gastric cancer cells (p < 0.05). Overexpression of circRTN4 inhibited the migration and invasion of  tumor cells, while pLCDH-circRTN4 reduced the ability of GC stem cells and expressions of MMP2 and OCT4.

Conclusion: Expression of circRTN4 decreases in GC, and contributes to the development and progression of this disease by increasing the levels of  LATS2 and binding with miR-424-5p. This suggests that circRTN4 may serve as a promising prognostic marker as well as a potential therapeutic target for  gastric cancer
Utility of EPA CompTox Chemical Dashboard for Next Generation Risk Assessment and Toxicity Prediction of Chemicals
Authors: Kim Donghyeon , Choi Jinhee
Published: June 2023

In recent years, the paradigm of toxicity science is moving toward predictive science. New approach methodologies (NAMs), including in chemico, in silico, and in vitro approach, provides a new feasibility to minimize the whole animal toxicity testing. To support these efforts, the U.S. Environmental Protection Agency (EPA)’s web-based CompTox Chemical Dashboard was developed and providing relevant data through a curation of diverse substances and predictive tools. In this review, we presented a comprehensive analysis of EPA CompTox Chemical dashboard’s available data, predictive tools and recent case studies using them. We also suggested a perspective of utility of EPA CompTox Chemical Dashboard for implementation of next generation risk assessment and toxicity prediction of environmental chemicals.
Sineantropos: Marjinal Antropoloji Yazıları
Authors: TÜNCER Emrah
Published: June 2023

Ahmet Güngören tarafından kaleme alınan Sineantropos: Marjinal Antropoloji Yazıları isimli kitap, sinemanın antropolojik boyutunu incelerken sinemanın insanlık tarihindeki önemini ve kültürel etkisini ele alıyor. Aynı zamanda sinemanın antropolojik bir araç olarak kullanımını, sinemadaki marjinallik ve farklılık temalarını tartışıyor. Yazar, sinemanın insanlar ve kültürler arasındaki etkileşimi nasıl yansıttığını ve şekillendirdiğini 14 bölümde açıklıyor. Kitaptaki yazılar, sinemanın hem bir sanat formu hem de bir iletişim ortamı olarak nasıl anlaşılacağını ortaya koyuyor. Bu yazıda da kitabın kapsamı, yaklaşımı ve katkısı detaylı bir şekilde analiz edilmeye çalışılmıştır.
GAMBARAN NILAI TROMBOSIT PADA PASIEN TUBERCULOSIS PARU YANG MENDAPAT PAKET OBAT ANTI TUBERKULOSIS (OAT) DI RUMAH SAKIT UMUM DAERAH KOTA KENDARI
Authors: Yusuf Muhammad Ilyas , Firdayanti Firdayanti , Salmawati Salmawati
Published: June 2023

ABSTRACT

Tuberculosis (TB) is an infectious disease that attacks the lungs caused by the bacteria Mycobacterium tuberculosis is transmitted through the air. One of the drugs used for TB disease rifampisin known as a cause of thrombocytopenia. This study aims to describe the number of platelets in patients receiving antituberculosis treatment medication package (OAT) in the General Hospital of City of Kendari. This type of research is descriptive , Automatic method. Based on the results of 18 samples of normal platelet values ​​obtained on the duration of treatment 2-6 months as many as 15 people (83.3%), while acquired decreased platelet count (thrombocytopenia) in the old first month of treatment as many as three people (16.7%).

Keywords :Tuberculosis lung, Anti tuberculosis drug, Platelet, RSUD Kendari city

 

ABSTRAK

 

Tuberkulosis (TB) adalah penyakit infeksi yang menyerang paru-paru yang disebabkan oleh kuman Mycobacterium tuberculosis yang penularannya melalui udara. Salah satu obat yang digunakan untuk penyakit TB yaitu rifampisin yang diketahui sebagai penyebab trombositopenia.Penelitian ini bertujuan untuk mengetahui gambaran nilai trombosit pada pasien tuberculosis paru yang mendapat perawatan paket obat anti tuberkulosis (OAT) di Rumah sakit Umum Daerah Kota Kendari. Jenis penelitian ini adalah deskriptif, pemeriksaan jumlah trombosit dilakukan menggunakan metode automatik.Berdasarkan hasil penelitian dari 18 sampel diperoleh nilai trombosit normal pada pasien dengan lama pengobatan 2-6 bulan sebanyak 15 orang (83,3%), sedangkan nilai trombosit tidak normal (trombositopenia) pada pasien  dengan pengobatan 1 bulan sebanyak 3 orang (16,7%) .

Kata kunci : Tuberkulosis paru, obat anti tuberkulosis, trombosit, RSUD Kota Kendari
UJI DAYA HAMBAT EKSTRAK DAUN KEDONDONG (Spondias dulcis L.) TERHADAP PERTUMBUHAN Escherichia coli ATCC 35218
Authors: Fusvita Angriani , Aulya Muhammad Sultan
Published: June 2023

ABSTRAK Kedondong merupakan tumbuhan tropis yang merupakan famili dari Anacardiaceae. Tanaman Kedondong digunakan sebagai obat tradisional untuk pengobatan diare, disentri, infeksi mulut, dan tenggorokan. Tanaman kedondong mengandung senyawa flavonoid, saponin, dan tannin yang merupakan senyawa aktif yang bersifatantibakteri. Tujuan penelitian untuk mengetahui daya hambat ekstrak daun kedondong (Spondias dulcis L.) terhadap Escerichia coli. Jenis penelitian yang dilakukan adalah eksperimen dengan ekstrak daun kedondong diberi perlakuan sebagai uji daya hambat terhadap pertumbuhan Escherichia coli. Ekstrak daun kedondong diperoleh dengan metode maserasi selama 5 hari dengan pelarut etanol. Pada penelitian ini menggunakan metode Kirby bauer disk diffusion (paper disk). Hasil penelitian menunjukkan bahwa terdapat zona bening disekitar paper disk yang menandakan ekstrak daun kedondong dapat menghambat pertumbuhan Escherichia coli. Ekstrak daun kedondong konsentrasi 5% memiliki zona hambat rata-rata 9,45 mm, konsentrasi 10% memiliki zona hambat rata-rata 11,65 mm, konsentrasi 15% memiliki zona hambat rata-rata 15,36 mm.Kata kunci: Zona Hambat, Daun Kedondong, Escherichia coli

ABSTRACT Kedondong is a tropical plant which is a family of Anacardiaceae. Kedondong plants are used as traditional medicine for the treatment of diarrhea, dysentery, mouth and throat infections. Kedondong plants contain flavonoid, saponin, and tannin compounds which are active antibacterial compounds. The aim of the study was to determine the inhibitory power of kedondong (Spondias dulcis L.) leaf extract against Escherichia coli. The type of research carried out was an experiment with kedondong leaf extract treated as an inhibitory test for the growth of Escherichia coli. Kedondong leaf extract was obtained by maceration method for 5 days with ethanol solvent. In this study using the Kirby bauer disk diffusion (paper disk) method. The results showed that there was a clear zone around the paper disk indicating that the extract of kedondong leaves could inhibit the growth of Escherichia coli. Kedondong leaf extract concentration of 5% has an average inhibition zone of 9.45 mm, a concentration of 10% has an average inhibition zone of 11.65 mm, a concentration of 15% has an average inhibition zone of 15.36 mm.

Keywords: Inhibitory Zone, Kedondong Leaves, Escherichia coli.
GAMBARAN GLUKOSA URINE DAN KETON URINE PASIEN HIPERTENSI DI RUMAH SAKIT UMUM DAERAH KOTA KENDARI
Authors: Susanti Susanti , Umar Ani , Trianti Ephi
Published: June 2023

Hypertension is an increase in systolic blood pressure of at least 140 mmHg and a diastolic pressure of at least 90 mmHg. Urine is product of is end of system of metabolik released by kidney as remains or discard. Urine glucose is a simple sugar group that still in the urine after passing through various processes in the kidneys. Ketones is a metabolic product of fatty acids and proteins consisting of three compounds namely acetoacic acid, acetone, and beta hydroxybutyrate acid. Urine test can provide information about organabnormalities, but it can also be used to establish the result of treatment especially to monitor the development of disease such as high blood pressure (hypertension). Study aims to determine the description of glucose urine and ketone urine with patient hypertension. This type of research is descriptive by using device "study sectional cross" with sampling technique purposive sampling where the number of samples of 30 people. Based on the results of a study of 30 glucose urine and keton urine in patients hypertension at city general hospital kendari obtained normal urine glucose as many 5 patients (16,7%) and abnormal urine glucose 25 patients (83,3). While, ketone normal as many 30 patients (100%).

Keywords : Hypertension, Glucose Urine, Keton Urine
FORMULASI LOTION EKSTRAK DAUN Meistera chinensis SEBAGAI TABIR SURYA Meistera chinensis LEAF EXTRACT LOTION FORMULATION AS SUNSCREEN
Authors: Rusli Nirwati , Fauziah Yulianti , Yusdin Elviyanti
Published: June 2023

Excessive sunlight can have a negative impact on skin health, but the bad effects of sunlight can be overcome by using sunscreen preparations. One of the natural ingredients that can be used in the manufacture of lotion sunscreenisleaf Meistera chinensis. Meistera chinensis is a plant that belongs to the Zingiberaceae family. Previous research has stated that Zingiberaceae species such as Etlingera elatior (torch ginger) have one of the functions as antioxidants. This study aims to formulateleaves Meistera chinensis as sunscreen and determine the SPF value obtained. Leaf extract was Meistera chinensis extracted using maceration method using methanol as solvent. Physical evaluation tests, stability tests, and sunscreen activity were carried out at three concentrations, namely 1% (F1), 3% (F2) and 5% (F3) concentrations. The three formulations are pale green, green, and dark green in color, have a melon flavor and have a liquid and semi-solid texture, are homogeneous with an oil-in-water (W/A) emulsion type and meet the pH requirements of 6 and 7. The stability test results show that the three formulas do not stable because it is not homogeneous and there is a change in aroma after the cycling test. The SPF value increased along with the increase in extract concentration, namely 7.46 (extra protection), 14.12 (maximum protection), and 19.06 (ultra protection).

Keywords:  Extract, Leaf Meistera chinensis, Lotion, Sunscreen, SPF
Lazer e esporte: a gestão de Vilas Olímpicas na cidade do Rio de Janeiro
Authors: Machado Tibério Costa José , Macêdo Mauro Moraes
Published: June 2023

O lazer e o esporte são dois elementos intrínsecos da vida humana, sendo elevados ao status de direito do cidadão brasileiro através da Constituição de 1988. Entretanto, em que pese a cidade do Rio de Janeiro, o Poder Público encontrou uma maneira particular de realizar o fomento de ambos os fenômenos, empregando as Organizações Sociais na gestão das Vilas Olímpicas. Sendo assim o estudo objetivou apresentar todo o processo necessário para habilitação e qualificação de uma Organização Social, juntamente com o processo que envolve a escolha delas para realização da gestão. O estudo empregou dois recursos metodológicos distintos, a pesquisa documental e a pesquisa observacional não participante, com a finalidade de responder todas as questões norteadoras existentes. Os resultados permitiram inferir que as Organizações Sociais passam por um processo rigoroso de avaliação e de análise, restando ao Poder Público fiscalizar a prestação do serviço e o emprego dos recursos públicos, com a finalidade de verificar a eficiência e a qualidade do atendimento prestado a população.
Dezvoltarea abilităților de comunicare la preadolescenți
Authors: RACU Iulia , RACU Igor
Published: June 2023

The article presents experimental research on communication skills and communication styles in preadolescents. The research sample included 100 preadolescents. The results of the study revealed that 24% of preadolescents have a low level of initiating social contacts, a large number of pre-adolescents are characterized by a low and medium level of developing of communication skills, as well as by deficient communication styles such as: dependent, aggressive, non-assertive and manipulative styles. The article describes the content and scientific basis of the psychological intervention program for the development of communication skills in preadolescents.
Reprezentarea socială a familiei contemporane în Republica Moldova
Authors: CAZACU Daniela
Published: June 2023

The study was aimed at developing the theoretical foundations regarding the family and social representation, determining the content of the social representation of the family in the Republic of Moldova, determining the possibilities for the development of social representation by modeling some episodes of change in social practice applying a psychological intervention program. The study involved 663 randomly selected individuals aged 17 to 50. The psychological intervention program developed by us can serve as a basis for the development of other psychosocial intervention programs. In the same way, we believe that the results of the experimental investigation, the psychological intervention program will be useful for school psychologists, teaching staff and counseling psychologists, and the program can be proposed to teachers who teach civic education in middle and high school.
L ∞−ASYMPTOTIC BEHAVIOR OF A FINITE ELEMENT METHOD FOR A SYSTEM OF PARABOLIC QUASI-VARIATIONAL INEQUALITIES WITH NONLINEAR SOURCE TERMS
Authors:   Higher School of Management Sciences-Annaba, Algeria, BENCHETTAH DJABER CHEMSEDDINE
Published: June 2023

This paper is an extension and a generalization of the previous results, cf. [3, 6, 8, 11]. It is devoted to studying the finite element approximation of the non coercive system of parabolic quasi-variational inequalities related to the management of energy production problem. Specifically, we prove optimal L∞-asymptotic behavior of the system of evolutionary quasi-variational inequalities with nonlinear source terms using the finite element spatial approximation and the subsolutions method