bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Chlorogenic Acid on Methotrexate-Induced Oxidative Stress and Inflammation in Lung Tissue of Rats
Authors: Mentese Ahmet , Demir Selim , Türkmen Alemdar Nihal , Ayazoglu Demir Elif , Aliyazıcıoğlu Yüksel
Published: September 2024

Although methotrexate (MTX) is a widely used chemotherapeutic agent, lung toxicity remains a significant problem, limiting its use. The molecular mechanism of MTX-related lung toxicity is not fully understood. However, increased reactive oxygen species-induced oxidative stress (OS) and inflammation play an important role in lung injury. Chlorogenic acid (CHA) is a natural phenolic compound that has been shown in recent years to have beneficial effects in many pathologies associated with OS and inflammation. This study focused on investigating for the first time, the potential therapeutic effects of CHA in the lung tissue of rats exposed to MTX. After lung toxicity was induced in rats by MTX (20 mg/kg) injection on the first day, two different doses of CHA (1.5 and 3 mg/kg) were used for treatment for 3 days. The results showed that CHA treatment reduced the level of pulmonary lipid peroxidation, inflammation and apoptosis and promoted the pulmonary antioxidant system in rats subjected to MTX. Taken together, the antioxidant and anti-inflammatory properties of CHA may play a central role in attenuating MTX-induced lung injury, but the exact mechanism needs to be investigated in more extensive preclinical studies.
The Role of Precision Agriculture, Climate-Smart Farming, and Sustainable Supply Chain Management in Boosting Agricultural Productivity in 2024
Authors: Ansar Muh. , Maemunah Maemunah , Said Sadly Ashari , Rahmadani Elfi , Dahliana A.Besse
Published: September 2024

This study explores the role of precision agriculture, climate-smart farming, and sustainable supply chain management in boosting agricultural productivity in 2024. The primary objective is to qualitatively analyze the literature to understand how these innovative practices contribute to enhancing agricultural productivity and sustainability. The research employs a qualitative literature review methodology, synthesizing findings from academic articles, industry reports, case studies, and empirical studies to provide a comprehensive overview of the current state of knowledge in this field.
The literature review methodology involves systematically collecting and analyzing scholarly sources that discuss various aspects of precision agriculture, climate-smart farming, and sustainable supply chain management. The study categorizes the literature into key themes, such as the technological advancements in precision agriculture, the principles and practices of climate-smart farming, and the impact of sustainable supply chain management on agricultural productivity and sustainability. Thematic analysis is used to identify patterns and trends in how these practices interact to influence agricultural outcomes.
The findings indicate that precision agriculture, through the use of advanced technologies like GPS, IoT, and AI, enables farmers to optimize field-level management regarding crop farming. This leads to increased yield, reduced waste, and better resource utilization. Climate-smart farming practices, including crop diversification, improved irrigation techniques, and soil health management, are essential for adapting to climate change and mitigating its impacts on agriculture. Sustainable supply chain management ensures that agricultural products are produced, processed, and distributed in ways that minimize environmental impact and enhance economic viability.
Assessing The Agonistic Continuum Scale as a measure of sexual sadism in a sample of community members and BDSM practitioners
Authors: Davidson Myles , Healey Jay
Published: September 2024

Sexual sadism refers to a sexual preference for fantasies and behaviours involving the infliction of humiliation, degradation, and suffering onto others. The conceptualization of sexual sadism remains a contentious issue in the literature, with some believing sexual sadism is qualitatively distinct from other deviant sexual preferences, while others suggest it lies on a continuum of sexually aggressive behaviours. This second approach, known as the Agonistic Continuum, is a relatively novel conceptualization of sexual sadism. Its companion scale, The Agonistic Continuum Scale (TACS), was created to measure sexual sadism as a dimensional construct in both forensic and community samples. Despite several validation studies being conducted, the factor structure of the TACS has yet to be independently assessed. As such, the current study sought to assess the factorial validity and measurement invariance of the TACS in a community sample made up of primarily BDSM practitioners using a series of confirmatory factor analyses and latent profile analyses. 248 Canadian adults (65.3% females, 75.6% BDSM practitioners) completed a survey containing a demographic questionnaire and several measures of paraphilic interest including the TACS. Results of the factor analyses suggested a four-factor model provided the best fit to the data. However, incorporating sex as a multigroup analysis factor rendered this model a significantly worse fit. Further, latent profile analysis results supported the ability of the TACS to identify groups differing in sexual sadism severity but returned significantly different fit statistics across sex groups. Taken together, while the results of past studies were partially replicated, our findings call into question the appropriateness of the TACS in mixed-sex and non-community samples.
Innovación y Competitividad: Perspectivas en la Manufactura Mexicana
Authors: Guadarrama Alba Yolanda , Contreras Rodríguez Eduardo , Padilla Guadarrama Anai Dafne , Contreras Rodríguez Leonardo
Published: September 2024

La innovación tecnológica, juega un papel fundamental en la conexión con la manufactura de la producción. Durante las últimas décadas, México ha desarrollado la industria manufacturera, que contribuye de forma significativa y directa a la economía del país, como lo es, la generación de nuevos empleos con ingresos de competencia nacional e internacional. La innovación funge como motor clave para el crecimiento económico, que genera una serie de beneficios en términos de producción, utilidad y renta. Además, permite a las empresas mexicanas participar y competir en la nueva apertura comercial internacional. El Tratado de Libre Comercio de América del Norte (TLCAN), 2018, atrajo inversión y tecnología. México desarrolla parques y clusters industriales, invierte en educación y formación continua. El objetivo del estudio es analizar las tendencias y desafíos del sector de producción manufacturero y su crecimiento, además, detallar el impacto económico de la innovación tecnológica, adopta tecnologías avanzadas que fortalecen la posición de México en la industria manufacturera internacional. Este trabajo aplica el método deductivo-cualitativo, con exploración institucional. Como resultado, detecto grandes debilidades en los procesos de manufactura de la producción, por lo que propone que las instituciones públicas y privadas apoyen la inversión, a fin de obtener rentabilidad.
Comunicación pública para Chihuahua en el nuevo entorno digital
Authors: Acuña Herrera Jesús Leoncio , Arana Nava Manuel Armando
Published: September 2024

El objetivo de este trabajo es fundamentar la necesidad de un Sistema de Medios Públicos para Chihuahua, pues siendo la entidad más extensa del país, carece de una televisora o una radio estatal de cobertura total. Hay un vacío informativo que no cubren ni los medios privados ni las redes sociodigitales. Se proponen dos alternativas, una que sea un sistema a cargo del gobierno estatal y otra, una red universitaria, desde la Universidad Autónoma de Chihuahua. En todo caso lo más factible es que opere desde una plataforma digital, habida cuenta el nuevo entorno de las redes, así como las tendencias de las audiencias. La metodología tiene un enfoque cualitativo, de tipo explicativa, su método se basa en la teoría fundamentada y sus instrumentos son entrevistas vía zoom y consulta de bibliografía especializada sobre los medios públicos en México. Se concluye que es necesario un Sistema que garantice el Derecho a la Información y la Libertad de Expresión de las diversas audiencias en Chihuahua, para fortalecer la pluralidad, la democracia y el tejido social.
Actividades lúdicas como estrategia para promover el lenguaje español en niños de la escuela Sunset Middle School
Authors: Hernández Guitiérrez Perla Zukey , Quiñones Dominguez Osiris , Moguel Torres Karina Dennise , García Barrera Cynthia Orlanda , Cossio Ponce de León Mariana
Published: September 2024

Introducción: Por diversos intereses, en muchas ocasiones los seres humanos deben emigrar de su nacionalidad para ser parte de otra nueva cultura, permitiéndoles tener una base cultural más amplia, conociendo dos culturas a profundidad, creando otros niveles de conocimiento tanto intelectual, cultural y social. Objetivo: El propósito del presente estudio fue comparar los cambios que generan las actividades lúdicas en el idioma español en 16 estudiantes, de 12 a 13 años del sexto grado de origen hispano, de la escuela Sunset Middle School, en la ciudad de Longmont, Colorado. Metodología: Es una investigación cuantitativa de tipo longitudinal con un pre y post test con grupo control. Resultados: El análisis revela que el P-Valor o significancia obtenida fue de 0.000, lo que es definitivamente menor que el nivel alfa de 0.05, por lo que se rechaza la hipótesis nula y se acepta la hipótesis alternativa, que si hay diferencias significativas en las calificaciones en el examen en idioma español de antes y después de realizar actividades lúdicas. Conclusión: las actividades lúdicas influyen de manera positiva en los procesos del habla del idioma materno.
Creative Music Olah Ulah | Tabuh Kreasi Olah Ulahh”
Authors: Edy Upadana I Ngurah
Published: September 2024

Tabuh Kreasi "Olah Ulah" is a musical composition inspired by the concept of tri guna, three basic human natures: animals, rajas, and tamas that are different from each other. Satwam is calm, honest, kind and wise. Rajas' nature is arrogant and haughty, while Tamas's nature is lazy and greedy. The three basic properties are interrelated and cannot be separated from each other. The concept is poured through the media revealed Gamelan Semara Dhana, a new Gamelan barungan in the karawitan of Bali. The method of creation used refers to the book "Panca Sthiti Ngawi Sani" by I Wayan Dibia. In this book, five stages are mentioned, namely the Inspiration Stage (Ngawirasa), the Exploration Stage (Ngewacak), the Conception Stage (Ngerencana), the Execution Stage (Ngewangun), and Ngebah. The form and structure of the work "Olah Ulah" is based on the concept of triangga that is pengawit, pengawak, pengecet. Pengawit describes the nature of sattwam: wise, honest, and calm. Pengawak describes the nature of rajas and tamas: arrogant, haughty and lazy. Pengecet describe the neutralization of these three properties so that balance is a sattwam trait.
Munyin Tanah Experimental Music | Musik Eksperimental Munyin Tanah
Authors: Candana I Kadek Hari , Muryana I Ketut
Published: September 2024

Munyin Tanah is an experimental music created to materialize the composer's ideas. This work's creation hopefully provides benefits in the form of new references for musicians and audiences. The method of creation in this work is found in a book by Brewster Ghiselin entitled The Creative Process. Roger Sessions (1952) explains that creating a musical work includes inspiration, conception, and execution. Based on this method, the composer produces experimental musical works by processing musical elements using media that combines non-musical and musical instruments. The musical idea represents sounds that arise from the ground, such as rumbling booming, and sounds produced from the contact of materials made out of soil, such as the sound of rain and earth shifting crust. This is processed through rhythmic integration that explores Balinese gamelan and drumming techniques in Western music, such as single, double, and paradiddle.
Music Composition Kulawarga Pencon | Komposisi Musik Kulawarga Pencon
Authors: Andika I Putu Restu , Saptono Saptono
Published: September 2024

Kulawarga Pencon is a musical work that summarizes the fusion of two cultural families in instruments based on Balinese and Javanese gamelan. The method for creating Kulawarga Pencon's work adopts the principles stated in the Method for Composing Musical Works (An Alternative) by inserting the process for creating works by I Wayan Beratha. This creation inspired musical processing based on an appreciation of the technique of playing gamelan instruments with pencon and processing rhythms based on various tempos. This approach creates a harmonious intertwining of tones in the formulation of the work. The musical structure of Kulawarga Pencon follows the Tri Angga concept, which consists of kawitan (precursor), pengawak (content), and pengecet (cover). Kawitan is formulated as an introduction that highlights the elements of rhythm, dynamics, and tempo as the basis for the development of the initial part. The crew expanded its scope by developing ancient techniques adapted to the stylist's perspective. The printer is interpreted as the culmination or red thread that transforms the formulation of the work toward the end. The musical work Kulawarga Pencon is composed and structured into three parts with various patterned characters but sourced from existing gamelan with knob techniques adapted to the stylist's interpretation of the interpretive power. This work's result is music processing through a unique mindset and creative process. An experimental result represents the interaction between two cultures, namely Balinese and Javanese Gamelan, in the form of a distinctive instrument, which is then used as a medium for working on the formulation of the work. For 14 minutes, this work was played by 17 musicians, including arrangers, with support from students from the Gamelan Arts Study and Performing Arts Education program at the Indonesian Institute of Arts Denpasar.
Penerapan Media Truth Or Dare untuk Meningkatkan Pemahaman Materi pada Pembelajaran PPKn Siswa Kelas V SD Inpres Jongaya Kecamatan Tamalate Kota Makassar
Authors: Safar Muhaymin  , Muhajir Muhajir  , Musdalifah Syahrir
Published: September 2024

The main problem in this research is how to apply Truth or Dare card media to improve understanding of the material in PPKn learning for fifth grade students at SD Inpres Jongaya District. Tamalate City. Makassar. This research aims to determine the application of Truth or Dare card media to increase understanding in PPKn learning for fifth grade students at SD Inpres Jongaya District. Tamalate City. Makassar. This type of research is class action research (Class Action Research) which consists of two cycles where each cycle is carried out in two meetings. Research procedures include planning, implementing actions, observing, reflecting. The subjects in this research were fifth grade students at SD Inpres Jongaya District. Tamalate City. Makassar as many as 32 people. The results of the research show that in the first cycle there were 16 students who got a score ≥70 with a learning completion percentage of 50%. Meanwhile, in cycle II, there were 30 students who got a score of ≥70 with a learning completion percentage of 94%. Based on the research results above, it can be concluded that the application of Truth Or Dare media to fifth grade students at SD Inpres Jongaya, Tamalate District, Makassar City can improve understanding of the material in Civics learning.
Pengembangan Media Flat Math Bebasis Etnomatematika pada Materi Bangun Datar di Sekolah Dasar
Authors: Imroatum Mardhiyyah  , Via Yustitia  , Dian Kusmaharti
Published: September 2024

This research is based on the development of 21st century learning, where PowerPoint is one of the applications that support learning with attractive designs. This research is a type of R&D development research with the ADDIE model as the development model. The research population was class II students, with a sample of 10 students from SDN Gempolkerep. The data analysis technique used is the Likert Scale. Flat shape material is introduced at the low grade level, and in this product, the material is associated with local culture, especially the culture in Mojokerto, East Java, which is adjacent to this research area. The results showed that the interactive Flat Math media had been tested for its feasibility and declared fit for use. The validation results of media experts get a percentage of 75% which indicates eligibility, while the results of the validation of material experts get a percentage of 86% which indicates very feasible qualifications. Linguist validation also shows decent results with a percentage of 76%. The average questionnaire results from student respondents show a percentage of 80.4% which indicates that this media is very feasible to use. In addition, the teacher's assessment also gave a percentage of 82%. Based on the data analysis, it can be concluded that Flat Math interactive media is appropriate for use in supporting learning in flat shape material.
Penerapan Terapi Bermain Meniup Baling-Baling Pada Anak Sekolah Dengan DBD Terhadap Penurunan Intensitas Nyeri Setelah Pemasangan Infus
Authors: Ari Andrean  , Ketut Suryani  , Maria Tarisia Rini
Published: September 2024

The process of installing an IV will cause pain which can disturb the child. Pain is an unpleasant event in individuals that can cause sufferers to feel sick. Apart from that, there will be changes in vital signs such as increased pulse rate, blood pressure and breathing, so it will be an unpleasant experience for the child. Pain from installing IV fluids in children can be minimized with non-pharmacological measures which aim to manage pain, namely with relaxation therapy, playing blowing propellers. To determine the effectiveness of blowing propeller play therapy on reducing pain in children when installing an IV. This research uses a descriptive case study with a nursing process approach with a case study design of 3 respondents, with a paper propeller game and the Wong Baker pain scale. The data collection process was carried out on respondents by blowing a propeller for 5 minutes on each respondent. The research results showed that play therapy blowing propellers was effective in reducing the intensity of pain in children after installing an IV as proven in An. B from scale 7 to scale 4, An. Z from scale 8 to scale 6, and An. R from scale 7 to scale 5. The results of the research are that it is hoped that propeller blowing therapy can reduce the intensity of pain in children after infusion.
Analisis Faktor Resiko yang Berhubungan dengan Kejadian Hipertensi pada Kepala Keluarga di Desa Waesala Kabupaten Seram Bagian Barat Provinsi Maluku Tahun 2024
Authors: Iksan Soumena  , Asriwati Asriwati  , Darwin Syamsul
Published: September 2024

Hypertension is a non-communicable disease (ncd) which is a major problem in the health sector and continues to increase every year even though many preventive and promotive measures have been developed following advances in science and technology. to find out analysis of risk factors related to the incident of hypertension in heads of families in tatinang and tita mandiri village waesala regency seram bagin barat tahun 2024. This type of research uses quantitative methods with a cross sectional approach. sampling method used a total sample population of 133 people. data analysis was carried out using univariate, bivariate analysis with chi square and multivariate analysis with logistic regression. Based on the results of the stress logistic regression test, p = 0.042; smoking p = 0.998; alcohol p = 0.996, and diet p = 0.000. diet is the dominant factor with a logistic regression value of p = 0.000 with an or or exp (b) = 12,722. There is a relationship between stress levels, smoking, alcohol and diet. these are the most dominant factors related to the incidence of hypertension in the tatitang and tita mandiri hamlets, while the age factor is not related to the incidence of hypertension.
Penerapan Kompres Jahe Merah untuk Mengurangi Nyeri Osteoarthritis pada Lansia di Wilayah Kerja Puskesmas Pucangsawit
Authors: Attyya Putri Azizah  , Norman Wijaya Gati
Published: September 2024

Background: Osteoarthritis often occurs in the elderly aged more than 60 years which is characterized by pain in the joints when moved. In Indonesia, 65% of elderly people aged 60 years and over experience osteoarthritis. Red ginger compress is an alternative nonpharmacological treatment to reduce joint pain in the elderly with osteoarthritis. Objectives: Knowing changes in pain scale in the elderly before and after doing red ginger compresses. Method: This application uses descriptive methods on 2 respondents, with pretest and posttest in the observation sheet of pain scale measuring instruments in the form of NRS (Numeric Rating Scale). Red ginger compress is given 2x a day in the morning and evening for 14 consecutive days within 20 minutes Result: There was a change in the intensity of the pain scale in both respondents. Mrs. P from moderate scale to mild scale and Mrs. E from moderate scale to painless scale. Conclusion: The application shows that there are changes in the pain scale before and after the red ginger compress, both in the first respondent and the second respondent. Red ginger compress can reduce osteoarthritis joint pain in the elderly.
Hubungan Pendidikan dan Level Pk Dengan Ketepatan Perawat dalam Melakukan Tindakan Resusitasi Jantung Paru (RJP) di Ruangan ICU dan IGD RS Prikasih Tahun 2024
Authors: Ratu Memei Dwi Prianti  , Weslei Daeli  , Arif Hidayatullah
Published: September 2024

Cardiopulmonary Resuscitation (CPR) or CPR is help for patients experiencing a heart attack where basic living rock is needed by applying pressure to the chest. Nurses have an important role in implementing cardiopulmonary resuscitation (CPR), especially in the emergency room. Skills in carrying out actions can have a direct impact on patient safety. Steps can be taken to improve the overall quality of medical treatment by increasing the education, knowledge and skills of attached nurses. The aim of this research is to find out the relationship between education and PK level with the accuracy of nurses in carrying out cardiopulmonary resuscitation measures in the ICU and emergency rooms at Prikasih Hospital in 2024. The research method that will be used is an analytical research design with a correlational design with a cross-sectional approach, a population of 40 technical respondents total sample and sample size of 40 respondents. Using the non-parametric Rank Spearman Rho test. The results show a relationship between education and the accuracy of nurses in carrying out cardiopulmonary resuscitation (CPR) in the ICU and ER with a P-Value of 0.026 < 0.05. And there is a relationship between the PK level and the accuracy of nurses in carrying out cardiopulmonary resuscitation (CPR) in the ICU and ER with a P-Value of 0.002 < 0.05. The conclusion is that education and level PK are very important in carrying out actions, because a person's knowledge can be seen from the abilities or skills they have, therefore education and level PK greatly influence the accuracy of cardiac resuscitation actions.
Unusual Multiple and Bilateral Combinations of Arterial and Neural Variations in the Axillae of Single Cadaver
Authors:   Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, USA, Tessema Chernet Bahru ,
Published: September 2024

Nerve During the dissection of the axillae and upper limbs of an 80-year-old male donor, multiple vascular and neural variations were encountered. On the right side, the thoracoacromial artery and the lateral thoracic artery were absent. On the left side the subscapular artery was absent, and the posterior cord of the brachial plexus gave branch to two upper subscapular nerves and then divided into radial nerve and a common stem that branched into thoracodorsal nerve, lower subscapular nerve, nerves to teres major and minor muscles and the axillary nerve. Additionally, in the left arm there was a variant communication between the musculocutaneous nerve and the median nerve. Although the existence of these variations is well documented in the literature as individual entities or few combinations, the occurrence of such multiple variations in a single cadaver in a limited area of the body involving vessel and nerves is not common. A multitude of variations in a small area of the body such as this can be a source of diagnostic and imaging interpretation errors. Unpredictable iatrogenic injuries can also occur during various procedures in the area such as during preparation of muscle flap, mastectomy with axillary lymph node dissection, reconstructive and aesthetic plastic surgery of the breast and other clinical procedures including shoulder arthroplasty.
Arte digital como estrategia de aprendizaje en el fortalecimiento de la lectoescritura
Authors: Salazar Herreño Alexander
Published: September 2024

El arte digital, como estrategia de aprendizaje, permite fortalecer habilidades comunicativas porque crea espacios donde los estudiantes pueden explorar y construir conocimientos íntegros. Por ello, se desarrolló un estudio a partir de un muestreo por conveniencia, que incluye a 57 estudiantes y 4 docentes de los grados 3, 4 y 5 de primaria de la Institución Educativa el Tejar en las sedes de Mantagua, Sicande y el Tejar, Colombia; con el objetivo de analizar si existe relación entre Arte digital como estrategia de aprendizaje y fortalecimiento de la lectoescritura. Por medio de una investigación cuantitativa, correlacional y transversal; aplicando dos instrumentos, de tipo Cuestionario para identificar el nivel de lectoescritura, cuya confiabilidad se sustentó con el juicio valorado de 3 expertos. Los hallazgos se analizaron mediante un proceso estadístico descriptivo e inferencial, a través de medidas de tendencia central y una prueba estadística Rho Spearman. Como resultado, se determina que existe una relación baja entre las dos variables, el p (valor) logrado 0,034 menor de 0,05 y una correlación 0,119, por lo cual se infiere que se acepta la hipótesis alterna “el arte digital como estrategia de aprendizaje fortalece la lectoescritura”. Asimismo, el estudio aporta patrones o elementos de una estrategia basada en “arte digital” que favorecerá el desarrollo de la competencia lectoescritura.
Pendampingan Digitalisasi Ingatan Tentang Sejarah, Kesenian Dan Tradisi Warga Sungai Bahar
Authors: Pradita Dennys , Mustafa Hanif Risa , Pratama Amor Gilang Seta , Lestari Inda , Mahanani Nugrahadi
Published: September 2024

Community memory is a legacy that has a very high value for a community or region. Community memories can be dangerous because they fade and even disappear. This paper will describe a program to document the memories of transmigrant communities in Sungai Bahar. This service program uses data collection modalities by collecting memories through interviews and then documenting them. The community that inhabits the Sungai Bahar area has been around since the 1980s. With the development of time, these speakers are getting older and decreasing in number. The existence of this documentation is a step to document memories so that future generations can know the origin and development of the region which can be accessed through gadgets so that the history and culture of the region does not fade with time.
Detección de fake news mediante el estilo lingüístico
Authors: Cortés de Narváez Laura Geraldine , Pinzón Serrano Manuela María del Rocío , Carvajal-Builes Juan Camilo
Published: September 2024

Las noticias falsas o fake news son noticias que se difunden rápidamente y traen consigo consecuencias negativas en el nivel social e individual, ya que generan creencias e ideas erróneas, ocasionan confusión e incluso ponen en riesgo el bienestar de los lectores. Aunque existen diferentes investigaciones, estos estudios no permiten analizar y entender los procesos psicológicos involucrados en las fakes news, así como identificar el estilo lingüístico diferencial que facilite su detección. Las fake news están relacionadas con diferentes temáticas entre las cuales se encuentran algunos temas de salud, como lo es el virus SARS-CoV-2, causante de la enfermedad COVID-19 por la que se declaró una pandemia que ha ocasionado 6.2 millones de muertes a nivel mundial, esto sugiere que la información relacionada con este virus sea una información basada en evidencia, ya que de ser falsa puede poner en riesgo la vida de personas. Por tal razón, se propuso como objetivo realizar un análisis comparativo de fake news y noticias verdaderas relacionadas con la pandemia del COVID-19 en países de habla hispana principalmente iberoamericanos mediante el análisis del estilo lingüístico. La metodología consta de un diseño comparativo de grupos con análisis multivariado, con una muestra constituida por 40 noticias verdaderas y 45 noticias falsas, relacionadas con la COVID-19. Como resultado, se encontró que existe un estilo lingüístico diferencial entre estos tipos de noticias que permitió la construcción de un modelo con capacidad predictiva del 84.7%, lo cual demuestra que el estilo lingüístico es una metodología que aporta la comprensión de fenómenos psicológicos, así como la discriminación de fake news.
Network Security Defense Strategy of Deep Reinforcement Learning Oriented to Game Battle
Authors: Liu Jianshu
Published: September 2024

With the popularity of online games and the increasing frequency of game battles, game platforms are facing more and more network security threats and attacks. In order to effectively deal with these threats, this study proposes a network security defense strategy of Deep Reinforcement Learning (DRL) for game warfare. Through the modeling of game battle environment and the application of DRL algorithm, this strategy can monitor and identify all kinds of network attacks in game battle in real time, and take corresponding measures to defend and deal with them. In this study, the corresponding experimental environment is designed, and the network security defense strategy based on DRL is evaluated and analyzed. The experimental results show that the strategy has obvious advantages in network attack detection rate and false alarm rate, and has good stability and reliability. In addition, the strategy also shows strong generalization ability and adaptability, and can effectively deal with different types of network attack threats. The results of this study are of great significance for strengthening the network security defense of the game platform and improving the user experience and the stability of the game environment.
Joint Optimization of Resource Allocation and Trajectory in UAV-assisted Wireless Semantic communication System
Authors: Sun Hanxiao , Xie Ping
Published: September 2024

In this paper, we investigate the resource allocation design of an unmanned aerial vehicle (UAV)-enabled semantic communication system, in which UAVs are assigned to transmit semantic information to multiple user nodes. Our goal is to maximize the semantic information sum rate of the communication system by jointly optimizing the subcarrier allocation strategy and the trajectory of the UAVs, taking into account the minimum required semantic data rate for each user node, the minimum semantic similarity that can be received, the maximum cruise speed of the UAVs, and the initial/final position of the UAVs. The design is formulated as a generally tricky mixed-integer nonconvex optimization problem. Subsequently, a computationally efficient iterative algorithm is proposed to obtain a locally optimal solution, and further proofs demonstrate that the proposed algorithm is guaranteed to converge to a solution that satisfies at least the KKT condition of the original optimization problem.
A Non-Standard Finite Difference Schemes for the Solution of Stiff Initial Value Problems
Authors: Obayomi Adesoji , Salaudeen Lukman
Published: September 2024

In this study, we introduce a novel non-standard finite difference (NSFD) scheme designed to address the challenges posed by stiff initial value problems. Stiffness in differential equations often leads to numerical instability and requires specialized methods for stable and accurate solutions. A novel set of numerical schemes for solving stiff ordinary differential equations caused by the decay of radioactive substances developed. This paper demonstrates the power of normalization in the discretization function. We employed non-local approximation and renormalization of the denominator function to create qualitatively stable schemes for a stiff ordinary differential equation. The schemes' stability properties were verified using numerical experiments. The schemes' performance is evaluated in comparison to other typical finite difference schemes
Cavernous Sinus Involvement in Multiple Myeloma
Authors: Kane Joseph
Published: September 2024

Though rare, multiple myeloma can potentially invade the cavernous sinus and result in cranial nerve dysfunction resulting in serious complications...
Lowering Anxiety of Students Towards Science Using a Culturally Responsive Pedagogy: A Test of the Efficacy of Culturo-Techno-Contextual Approach
Authors: Adam Umar , Akintoye Hakeem , Oludipe Olajumoke S. , Lameed Soladoye , Bankole Isaac , Abdulkareem Kaothar , Assaf Mohammed
Published: September 2024

Culturo-Techno-Contextual Approach (CTCA) is a culturally responsive teaching strategy that empowers African students to learn science meaningfully in the digital age. CTCA integrates culture, technology, and locational context to enhance students' comprehension of scientific concepts. This study examined the effectiveness of CTCA in reducing students learning anxiety towards science concept. A pretest-posttest, non-equivalent group design was adopted. The sample comprised 121 senior secondary II students (equivalent to grade 11) from two purposively selected schools in Lagos State. The Nutrition Anxiety Scale, which had a reliability coefficient of 0.70, was used data collection. The treatment period lasted four weeks following the pretest. The experimental group was taught using the CTCA, while the control group received conventional lecture-based instruction. The results revealed that those students who were taught using the culturo-techno-contextual approach had a significantly lower level of anxiety than the comparison group [F (1, 198) = 16.54; p < 0.05]. A statistically significant difference was not found based on gender [F(1,49)=.49; P >0.05]. Therefore, within the limitations of this study, it was concluded that CTCA is an effective teaching approach for lowering anxiety towards science. It is recommended that CTCA be adopted in teaching scientific concepts.
Tradiciones sobre el Arca en los Libros de Samuel (1 Sam 4-6; 2 Sam 6)
Authors: Álvarez Barredo Miguel
Published: September 2024

Las tradiciones sobre el arca en los libros de Samuel se concentran en 1 Sam 4-6, y 2 Sam 6. El narrador las ofrece ya sistematizadas y colocadas en el ámbito de las tribus del norte, y en la entronización del rey David en Jerusalén respectivamente. Pero en una observación más atenta se descubre que el arca, símbolo de la presencia divina en medio de su pueblo en la franja pre-monárquica hasta su asentamiento definitivo en la ciudad santa, ha sufrido una serie de contratiempos e imprevistos, que confieren a este itinerario un aire de enfrentamientos entre los hebreos y filisteos que retratan las vivencias religiosas ante Dios en esta franja. Simultáneamente el narrador ha sabido entrelazar las tradiciones locales con las líneas maestras de la redacción los libros de Samuel, logrando que relatos autónomos formen una secuencia literaria y teológica. Esta proporciona una óptica enriquecedora, donde se aprecia la variedad de facetas teológicas que han sido superpuestas por el redactor final, sin oscurecer sus informaciones originarias.
BIOMARCADORES DE METILAÇÃO DE DNA EM BIÓPSIAS LÍQUIDAS NO CÂNCER DE MAMA: REVISÃO INTEGRATIVA
Authors: Siqueira Gisele Aparecida , Tenani Graciele Domitila
Published: September 2024

Introdução: O diagnóstico precoce é fundamental para o prognóstico de tumores, especialmente nas neoplasias mamárias, uma das principais causas de mortalidade feminina. A metilação do DNA é uma alteração epigenética comum na carcinogênese. As biópsias líquidas visam detectar o ctDNA antes da progressão clínica. Objetivo: Demonstrar a viabilidade da aplicação clínica de biópsias líquidas utilizando biomarcadores de metilação de DNA livre de células circulantes (ccfDNA) no câncer de mama de localização primária. Métodos: Estudo de revisão integrativa. As bases de dados Pubmed/Medline e Scielo foram selecionadas, e a busca foi realizada utilizando os seguintes descritores e operadores booleanos “Breast cancer”, “DNA and “Methylation”, “Biomarkers” and “Methylation”, “Liquid biopsy” e “Epigenetics”. Foram incluídos artigos completos e originais publicados nos últimos cinco anos, englobando as informações necessárias sobre biomarcadores de metilação do DNA em biópsias líquidas no câncer de mama. Artigos com câncer de mama masculino, câncer de mama não humano e biópsias líquidas com fluidos não sanguíneos. Resultados: No total, 19 estudos foram identificados nas bases de dados eletrônicas, 14 foram excluídos e ao final do processo de seleção 5 estudos foram incluídos na síntese qualitativa. Os estudos revisados identificaram biomarcadores preditivos para diagnóstico precoce de neoplasias mamárias. Destacaram a importância de superar a limitação dos métodos convencionais, especialmente em mulheres jovens, devido ao tecido glandular denso. Análises baseadas no TCGA apresentaram resultados promissores, com sensibilidade e especificidade elevadas. Técnicas como PCR digital foram recomendadas por sua alta precisão diagnóstica. Conclusão: A identificação de biomarcadores e o uso de técnicas sensíveis, como a PCR digital, foram consideradas essenciais para o diagnóstico precoce de neoplasias mamárias, especialmente em mulheres jovens, onde os métodos convencionais apresentam limitações.
REPROCESSAMENTO DE APARELHOS E ACESSÓRIOS ENDOSCÓPICOS: REVISÃO INTEGRATIVA
Authors: Rodrigues Elisa Carla , Tenani Graciele Domitila
Published: September 2024

Introdução: O uso da endoscopia revolucionou o campo da gastroenterologia, auxiliando principalmente no diagnóstico, monitoramento e gerenciamento de distúrbios gastrointestinais. O procedimento realizado tem como principal vantagem não necessitar de intervenção cirúrgica exploratória invasiva para auxiliar no diagnóstico, expondo o paciente ao risco menor de complicações, como má cicatrização e infecções bacterianas no período pós-intervenção. Para diminuir ou anular o risco de contaminação de um paciente para o outro, devem ser seguidos protocolos rígidos de desinfecção. Objetivo: O estudo abordou os principais riscos de infecções, oriundos do reprocessamento inadequado do endoscópio para o operador e o paciente. Assim, foi realizada uma revisão integrativa, afim de apontar para os fatores de riscos que contribuem com a infecção durante e após o reprocessamento endoscópico, analisar quais foram os avanços nas técnicas de desinfecção utilizadas e, por fim, recomendar medidas que possam aumentar as medidas de biossegurança. Métodos: Para a execução do trabalho, foram consultados artigos e protocolos oriundos das bases de busca como: Google acadêmico, Lilacs e Pubmed, publicados no período de 2013 a 2023. Resultados: A busca inicial identificou 78 artigos (N = 78); quando aplicados os critérios de exclusão, foram excluídos 69 artigos (N=69) e, foram utilizados para esta revisão 9 artigos (N=9). Conclusão: Foi possível contribuir, com esta proposta de pesquisa, para a difusão de um conhecimento técnico-científico que ajude os profissionais da saúde a tomarem providências e reflexões pertinentes acerca do reprocessamento do aparelho endoscópico e seus acessórios.
COMUNICAÇÃO DE MÁS NOTÍCIAS EM CUIDADOS PALIATIVOS PEDIÁTRICOS: REVISÃO INTEGRATIVA
Authors: Alves Thamiris Monteiro de Lima , Tenani Graciele Domitila
Published: September 2024

Introdução: A ação de comunicar notícias desagradáveis é um ato que requer um olhar e uma postura diferenciada. Objetivo: O presente trabalho faz uma revisão da literatura referente as formas e estratégias existentes e a serem implantadas acerca da comunicação das más notícias no setor pediátrico. O mesmo também aborda os desafios encontrados pelos profissionais de Enfermagem e como eles vivenciam essa situação, referente aos métodos e protocolos que os foram ensinados na jornada universitária e profissional. Métodos: O artigo trata de uma revisão narrativa da literatura, tendo por finalidade analisar e agrupar estudos referentes a comunicação de más notícias em cuidados paliativos pediátricos. Os dados foram coletados com auxílio dos seguintes descritores: “Obstáculos à comunicação”, “Crianças”, “Pediatria”, “Comunicação em Saúde”, “Cuidados Paliativos”, identificados pelos Descritores em Ciências da Saúde (DeCS). Os índices utilizados foram: Scielo, PubMed e Google Acadêmico. Foram utilizados os descritores booleanos AND e OR. Resultados: Após utilizar os descritores e palavras-chave, inicialmente foram selecionados um (N=30) artigos; estabelecidos os critérios de exclusão considerando os artigos repetidos, incompletos ou não relacionados ao assunto, foram excluídos um N= 20 artigos, totalizando N= = 10 artigos. Após realizar uma releitura, considerando referências dos artigos pré-selecionados, um N = 6 artigos foram adicionados, totalizando assim N = 16 artigos utilizados no estudo. Discussão: Com essa análise é possível perceber as falhas existentes nesse tipo de comunicação e os pontos que devem receber uma maior atenção durante o tempo de profissionalização dessas equipes de Enfermagem e multidisciplinar como um todo, visando serviços e cuidados mais humanizados e de maior qualidade para os pacientes, familiares e profissionais. Conclusão: Conclui-se que a transmissão de más notícias deve ser feita de forma clara, segura e respeitosa, porém, a falta de domínio e abordagem dessa temática durante a graduação e a formação dos profissionais de saúde, geram condutas despreparadas e amadoras, que impactam direta e negativamente na vida do cliente, familiar e da própria equipe
DIABETES MELLITUS TIPO 2: O PAPEL DA GENÉTICA E DA NUTRIÇÃO NA PREVENÇÃO E CONTROLE DA DOENÇA: UMA REVISÃO INTEGRATIVA
Authors: Lopes Karina Fernanda Caetano , Tenani Graciele Domitila
Published: September 2024

Introdução: O diabetes mellitus tipo 2 (DM2) é uma doença de incidência global. No ano de 2021, cerca de 537 milhões de adultos no mundo, com idade entre 20 e 79 anos, viviam com DM2. Foram identificados cerca de 28 genes associados ao DM2. Variantes genéticas foram identificadas, sendo o gene receptor ativado por proliferadores de peroxissomo gama (PPARG) e o polimorfismo Pro12Ala (a substituição de uma alanina por prolina na posição 12 no éxon B da região NH2 terminal) uma das primeiras a serem associadas ao DM2. Objetivo: Este trabalho foi realizado com o objetivo de mostrar a importância de se ter uma dieta equilibrada no DM2 associada a fatores genéticos, para os pacientes conseguirem ter uma vida saudável. Métodos: A pesquisa foi realizada por meio de estudos publicados na íntegra na literatura em português ou inglês, entre os anos de 1995 e 2023, em bases de dados como a Biblioteca Virtual em Saúde (BVS), Google Acadêmico, PubMed e Scielo. Resultados: Foi possível compreender que para controlar a doença e levar uma vida saudável, é necessário reduzir o consumo de açúcar, e não o excluir totalmente da dieta. Além disso, é importante fazer refeições nos horários adequados e praticar atividades físicas, as quais podem modular a expressão de genes associados ao mau prognóstico da doença. Conclusão: A informação, educação e conscientização das pessoas são essenciais para combater o DM2 e melhorar a qualidade de vida dos indivíduos afetados.
Uji Aktivitas Antimicrobial dan Kandungan Senyawa Kimia Bunga Cempaka Putih (Michelia Alba DC)
Authors: Safrina Safrina
Published: September 2024

Artikel ini mendeskripsikan tentang uji aktivitas antimicrobial dan kandungan senyawa kimia bunga cempaka putih (Michelia Alba DC). Proses pengujian dilakukan menggunakan Kromatografi Gas-Spektroskopi massa terhadap Escherichia coli dan Staphilacocus aureus. Hasil Pengujian menunjukkan bahwa karakterisasi dari ekstrak n-heksana  menghasilkan 46 komponen kimia dengan 5 komponen utama. Ekstrak ini memperlihatkan adanya aktivitas antimicrobial/anti infeksi. Pada konsentrasi 50%, zona hambat untuk masing-masing mikroba uji Escherichia coli dan Staphilacocus aureus adalah 13 dan 30 mm, pada konsentrasi 20% adalah 12 dan 21 mm, pada konsentrasi10% adalah 9 dan 10 mm dan 5% adalah 8 dan 10 mm. Kajian ini menyimpulkan bahwa cempaka putih terbukti dapat menghambat aktivitas dan bakteri penyebab infeksi, sehingga cocok untuk digunakan sebagai obat antiinfeksi.
Abstract
This article describes the antimicrobial activity test and the content of chemical compounds in White Cempaka Flowers (Michelia Alba DC). The testing process was carried out using Gas Chromatography-Mass Spectroscopy on Escherichia coli and Staphylococcus aureus. The test results showed that the characterization of the n-hexane extract resulted in 46 chemical components with five main parts. This extract showed antimicrobial/anti-infective activity, with each test concentration being: 1) at a concentration of 50%, the inhibition zone for each test microbe Escherichia Coli and Staphylococcus Aureus was 13 and 30 mm, 20% was 12 and 21 mm, 10% is 9 and 10 mm and 5% is 8 and 10 mm. This study concluded that the Michelia Alba DC was proven to inhibit the activity of bacteria in causing infection.