bluuebunny/crossref_metadata_2025 huggingface dataset:
STRUCTURE-BASED DRUG DESIGN: UNDERSTANDING DANCING BIO-MOLECULES
Authors: Sharma Priyankal , Mishra Rupal , Kose Aparna Patil , Kaur Dr. Gaganjyot , Purandare Dr. Krupa , Kaur Dr. Rupinder , Mangaonkar Dr. Kiran
Published: June 2024

Structure-based drug design (SBDD) is a powerful approach that leverages the 3D structures of target proteins to guide the rational design of potential drug candidates. By identifying and optimizing ligands that specifically interact with the active sites of target proteins, SBDD aims to develop drugs with enhanced potency, selectivity, and reduced off-target effects. This review provides an overview of the key principles and methodologies involved in SBDD, including target selection, protein structure determination, active site identification, ligand docking, and scoring algorithms. We discuss the advantages and challenges of SBDD, such as addressing target flexibility, modeling membrane proteins, and incorporating water molecules in ligand-protein interactions. Furthermore, we explore emerging trends in SBDD, including the integration of artificial intelligence and machine learning techniques, multi-target drug design, and personalized medicine applications. The potential impact of SBDD on drug discovery for rare diseases and drug resistance is also highlighted. Despite its successes, future issues for SBDD, such as data management, reproducibility, ethical considerations, and regulatory adaptation, need to be addressed to maximize its potential in accelerating drug development. In conclusion, SBDD continues to be a critical component of the drug discovery pipeline, and its continued advancement promises to drive the development of innovative and targeted therapeutics for a wide range of diseases.
EFFECTS OF DIFFERENT MEDICATIONS USED TO TREAT ALZHEIMER'S DISEASE ON CAENORHABDITIS ELEGANS
Authors: Desai Divyata , Mishra Dr. Kundan Kumar
Published: June 2024

The most prevalent kind of dementia is Alzheimer's disease, which develops when the brain no longer functions properly. The main causes of issues are with behaviour, thinking, and memory. A complex ailment called Alzheimer's is characterized by abnormal protein accumulation in the brain regions. Although the precise molecular causes of this disease are not yet known, it is well acknowledged that a protein homeostasis network exists. When they serve as an enzyme substrate or a signaling molecule to activate a biochemical pathway, metabolites have an impact on crucial steps in cellular pathways. It is relatively new to model Alzheimer's disease in a basic microscopic organism like C. elegans. Worms that have the human amyloid beta peptide genetically altered to be expressed in muscle cells build up immunoreactive deposits of amyloid beta 1-42 as well as insoluble beta amyloid, which is seen in senile plaques in AD brains. The impact of various medications can be studied in C. elegans
IMPACT ON LIVER CIRRHOSIS ON MANKIND AND THEIR DIAGNOSTIC TOOLS
Authors: Rahul Mr. , Kumar Akash
Published: June 2024

The liver is a vital organ in the body of a human and is in charge of a variety of processes that support immunity, digestion, detoxification, metabolism, and vitamin storage, among other things. About 2% of an adult's body weight is made up of it. Due to its dual blood supply from the hepatic artery (about 25%) and portal vein (around 75%), the liver is a special organ. One of the top 10 fatalities in the western world is cirrhosis. Alcoholism and viral hepatitis are the main global causes. Iron overload and biliary disorders are additional factors. In adult the liver weighs between 1400 and 1600 gm, and 2.5% of body weight. The liver is a vital organ in the body of a person and is in charge of a variety of processes that support immunity, digestion, detoxification, metabolism, and vitamin storage, among other things. Because of ongoing liver injury, cirrhosis is portrayed as the histological development of recovering knobs encompassed by stringy groups, which brings about entry hypertension and end-stage liver sickness. Recent developments in the knowledge of pathophysiology and natural history. Further developed administration, personal satisfaction, and future for cirrhotic patients because of worked on comprehension of cirrhosis and in the treatment of its complexities.
RECENT ADVANCES IN THE FIELD OF OPTOMETRY
Authors: Khan Hiba , Singh Dr. Anshu Kumar
Published: June 2024

Optometry is a specific medical service calling that includes inspecting the eyes and related structures for deformities or irregularities. Optometrists are medical services experts who normally give extensive essential eye care. The World Gathering of Optometry, World Wellbeing Association and around 75 optometry associations from more than 40 nations have taken on the accompanying definition, to be utilized to portray optometry and optometrist. Optometry is a healthcare profession that is autonomous, educated, and regulated (licensed/registered), and optometrists are the primary healthcare practitioners of the eye and visual system who provide comprehensive eye and vision care, which includes refraction and dispensing, detection/diagnosis and management of disease in the eye, and the rehabilitation of conditions of the visual system. Optics started with the improvement of focal points by the antiquated Egyptians and Mesopotamians, trailed by hypotheses on light and vision created by old Greek thinkers, and the advancement of mathematical optics in the Greco-Roman world. Optics was fundamentally transformed by the improvements in the archaic Islamic world, like the starting points of physical and physiological optics, and afterward altogether progressed in early present day Europe, where diffractive optics started. These previous investigations on optics are presently known as "old style optics". The expression "current optics" alludes to areas of optical examination that generally evolved in the twentieth 100 years, like wave optics and quantum optics. In addition to the more conventional approaches that are currently in use, new technologies for multifocal contact lenses and spectacles are being developed to address the worldwide rise in myopia. New effective drops both remedy and over the counter, add to the optometric restorative armoury. An as of late endorsed fundamental medication might change the board designs for thyroid eye sickness. We are seeing a dramatic flood in recent fads, innovations, and medicines in optometry and expect to rouse some further examination by giving you an undeniable level prologue to a portion of the promising newcomers in eye care.
NEXT GENERATION DIAGNOSIS OF MICROBIAL DISEASES: ADVANCEMENTS, TECHNIQUES, AND APPLICATIONS
Authors: Sobit Mr. , Naaz Zeba
Published: June 2024

A major hazard to global health that affects millions of people and puts a strain on healthcare systems everywhere is microbial illness. In order to successfully study and treat microbial disease, ongoing research is required due to the emergence of new infections, the development of strains that are drug-resistant, and changes in healthcare practises. The science of microbiology has recently developed new strategies and tools to meet this challenge. This abstract offers a summary of the most recent developments and emerging trends in the field of microbial diseases. In the first section, we go over cutting-edge approaches to identifying and detecting infections, such as metagenomics, quick diagnostics based on nucleic acid amplification, and rapid diagnostics based on nucleic acid amplification. These developments allow for quicker and more precise identification, surveillance, and early detection of infectious pathogens.Second, we examine the expanding use of artificial intelligence and machine learning in the study of microbial diseases. In predicting illness patterns, determining treatment resistance, and developing more effective vaccines, AI-driven techniques have shown to be invaluable. These methods present unheard-of possibilities for personalized medicine, where treatment plans can be customized for specific individuals in light of their individual microbial profiles. We then explore the area of antimicrobial resistance (AMP), which has grown to be a significant worldwide health issue. The development of alternate antimicrobial agents and treatment approaches, such as bacteriophage therapy, is required due to AMR, which we study. Innovative strategies to tackle AMR in farming and animal husbandry while understanding the value of a one health approach to tackling this challenge. We also discuss new developments in vaccine production and vaccine administration methods. The development of safer and more effective vaccines against a variety of microbial pathogens has been hastened by advancements in revers vaccinology, nonpartial based adjuvant, and mRNA vaccine technologies, enabling the ability to stop future outbreaks and eradicate specific diseases. In conclusion, interdisciplinary cooperation, cutting-edge technologies, and data-driven methodologies define the next generation of microbial illness research. These developments have the potential to enhance illness detection, diagnosis, treatment, and prevention, ultimately paving the way for a healthy local and global population. To effectively handle the changing difficulties faced by microbial disease in the future, it is necessary to continue investing in research, global corporations, and public health infrastructure.
SAFINAMIDE: AN ADDITIONAL APPROACH FOR PATIENTS WITH PARKINSON’S DISEASE
Authors: Gosain Srishti , Goyal Mohit , Garg Sakshi
Published: June 2024

Safinamide is a neuroprotective agent that acts as a selective monoamine oxidase B (MAO-B) inhibitor and also has weak sodium and calcium channel-blocking properties. It is used as an adjunctive treatment for Parkinson's disease-related motor alterations in patients who are already taking levodopa. Safinamide has been studied for its potential neuroprotective effects and its impact on various non-motor symptoms (NMS) in related to Ph.D Research has indicated that safinamide can improve depressive symptoms in Parkinson’s patients, reduce daytime sleepiness, and enhance overall sleep quality. Additionally, it has been discovered to have advantageous impacts on cognitive function in patient’s withPD-related mild cognitive impairment. Additionally, safinamide has been investigated for its role in managing pain in PDpatients with erratic motor function, leading to reduced pain intensity and improved quality of life. Furthermore, safinamide has shown promise in alleviating urinary symptoms in PD patients, such as urgency, frequency, and incontinence, suggesting it could be an effective treatment alternative for these NMS. Overall, safinamide appears to be apotential approach for treating several non-motor symptoms of PD, and its neuroprotective properties make it valuable in managing the illness's advancing nature. But further study is required to properly comprehend its mechanisms of action and validate its effectiveness in larger, longer-term clinical trials.
TELEPHARMACY AND REMOTE PATIENT MONITORING
Authors: Sagar Mr. Shachan
Published: June 2024

Telepharmacy and remote patient monitoring are emerging technologies in the field of healthcare that leverage telecommunication and information technology to enhance patient care and improve medication management. Telepharmacy involves the delivery of pharmaceutical care remotely, enabling pharmacists to provide medication-related services to patients who may be located in underserved areas or have limited access to healthcare facilities. Remote patient monitoring involves the use of devices to collect and transmit patient data to healthcare providers, allowing for real-time monitoring and timely intervention. This chapter provides an overview of telepharmacy and remote patient monitoring, highlighting their benefits, challenges, and potential applications in improving patient outcomes.
FUTURISTIC TRENDS OF CHRONOPHARMACOLOGY
Authors: Bala Raj , Kaur Prabhjot , Puri Gautam Raj
Published: June 2024

An obvious physiological characteristic of living organism is the variability of biological phenomenon over time. This variability undergoes rhythmicity at the cellular, organ and systemic level [1-4].
MANAGEMENT THOUGHTS
Authors: P. Subakaran Mr.
Published: June 2024

Management Thought is the theory that guides management of people in the organization. It is based on different assumptions about human beings and the organizations for which they work. Management theories provide recommendations for management strategies, frameworks and tools that organizations can implement to aid their workforce or culture. In this Paper, the Author has made attempts to highlight his personal Management Thoughts in the areas of Sales, Marketing, Human Resource, Strategy, Academics, Research, Industry, Philosophy and Future Trends.
ENTREPRENEURSHIP IN EMERGING MARKETS AND THE 4TH INDUSTRIAL REVOLUTION: OPPORTUNITIES AND CHALLENGES
Authors: Asare Charles , Sekyere Kwame Ntim , Boateng Bernard Ofosu , Walden Beulah Hilda , Tannor William Asamoah , Abasimi James Abadektemi
Published: June 2024

This chapter focuses on the ever-changing visage of entrepreneurship in emerging markets, specifically within the framework of the 4th Industrial Revolution. The chapter covers the unexplored market potential and specific demands within many sectors, including agriculture, healthcare, education, and the economy. Entrepreneurs operating inside emerging economies have a unique opportunity to effectively respond to pressing needs, thereby generating a favourable influence on both individuals' well-being and global progress. This chapter provides valuable insights into the evolving entrepreneurial landscape and outlines the necessary measures to promote sustainable growth and development.
ROLE OF CAREER PLANNING AND DEVELOPMENT AS A BOOSTER TO HUMAN RESOURCES DEVELOPMENT
Authors: M N Anusha , Nair Dr. Santhi G , Panicker Rogen K
Published: June 2024

Career management is successful when the firms utilize the abilities and knowledge of their workforce to the maximum and they feel motivated enough to achieve maximum results and are contended with their jobs. This helps the organization to reach its goals. The inability to motivate the workers by planning their careers may lead to impede the process of manning vacant posts, a cut of the employee involvement and a wasteful misuse of the funds allocated to training and development programs. The shortcomings of career planning may lead to frustration, ill feelings of not being appreciated by the firm. Non identification of the right position leads to job switch and / or the firm itself. Career planning involves both individual and firm responsibilities. In the modern business environment, career management responsibility vests more on the individuals themselves. Organisations need to have and keep a potent workforce, and are considered as the main resource for attaining competitive advantage. Most progressive firms envision and apply an integrated career management system.
"INDIA'S LEADERSHIP IN THE G20: PRIORITIES AND CHALLENGES OF 2023 PRESIDENCY"
Authors: Kazmi Zoya , Bhagwani Nishtha
Published: June 2024

The G20 presidency holds immense significance for India as it provides a unique opportunity to shape global economic and political agendas. The G20, a premier forum for international economic cooperation, represents a dominant force with its members collectively accounting for 85% of global GDP, 75% of international trade, and encompassing two-thirds of the world's population. With the support of the TROIKA, comprising Indonesia, India, and Brazil as the previous, current, and upcoming presidencies respectively, all of which are developing countries, India's G20 presidency presents a unique opportunity to emerge as a representative for the Global South. In 2023, India’s G20 presidency, marking a pivotal moment in its emergence as a global leader. An exceptional chance of India's leadership in this global institution opens doors for accelerating sustainable growth not only within India but also across the emerging world and beyond. The research aims to critically analyse India's G20 presidency in 2023, examining its priorities, initiatives, and challenges. The paper begins by providing an overview of the G20 and its role in international cooperation. It then delves into India's key objectives and themes during its presidency, such as inclusive growth, sustainable development, digitalization, and climate change. The India's domestic context, including its economic reforms, political dynamics, and regional influence plays an important role in shaping its G20 presidency. The opportunities presented by the G20 also bring forth a multitude of complex challenges that demand thoughtful and concerted efforts to overcome, including geopolitical tensions, differing national interests, and the complexities of multilateral negotiations. The paper assesses India's efforts in advancing these priorities through policy initiatives, negotiations, and diplomatic engagements. It concludes the implications of India's G20 presidency in 2023 for global governance, its impact on India's standing in the international community, and its potential long-term outcomes for global economic cooperation.
BARRIERS TO KNOWLEDGE MANAGEMENT PRACTICES IN IT SECTOR – A STUDY WITH SPECIAL REFERENCE TO SELECTED COMPANIES IN TECHNOPARK
Authors: S Dr. Sini Raj
Published: June 2024

Human Resources Management encompasses managing the knowledge of the employee. The current Human Resources Management (HRM) scenario is not only product centric but also knowledge centric. The organizations exactly need to create a good work environment that help to promote Knowledge Management (KM) eventually that results in enhanced knowledge acquisition and knowledge transfer. With effective and practical knowledge management, organizations can disseminate information and also acquire valuable information to improve the efficiency of their practices. Hence, it would be appropriate to study barriers to Knowledge Management Practices (KMP) in the context of IT Companies in Technopark.
WORK-LIFE BALANCE AND STRESS MANAGEMENT'S EFFECTS ON JOB SATISFACTION AMONG WORKING WOMEN
Authors: Pareek Ms. Sweta , Anamika Dr.
Published: June 2024

The modern workforce landscape has seen a significant influx of women who are striving to excel in both their careers and personal lives. This chapter explores the intricate interplay between work-life balance, stress management, and job satisfaction among working women. Work-life balance encompasses the equilibrium between professional commitments and personal responsibilities, presenting a unique challenge for women due to societal expectations and multi-faceted roles. Stress management, on the other hand, entails adopting strategies to cope with the stressors arising from the convergence of work and personal life. The relationship between these factors is complex and multi-dimensional. A balanced work-life equation is found to positively influence job satisfaction among working women. When they can allocate ample time and energy to their families, self-care, and personal pursuits, their overall job satisfaction tends to increase. In contrast, an imbalance between work and personal life leads to heightened stress levels, contributing to burnout and decreased job satisfaction. Stress, emerging from the struggle to meet both professional and personal obligations, acts as a barrier to optimal job satisfaction. To address these challenges, organizations can play a pivotal role by offering flexible work arrangements that allow for better integration of work and personal responsibilities. Supportive policies such as extended parental leave, on-site childcare facilities, and wellness programs contribute to mitigating stressors related to family obligations. By fostering an inclusive work culture that encourages open discussions about work-life balance, societal norms can be reshaped, empowering both women and men to prioritize holistic well-being. Stress management interventions, including mindfulness practices and time management strategies, can effectively alleviate stress and enhance job satisfaction. Through training and education initiatives, working women can acquire practical tools to manage stress, navigate challenges, and maintain a healthy balance between work and personal life. By recognizing the interconnected nature of work-life balance, stress management, and job satisfaction, individuals and organizations can collectively pave the way for a more content, engaged, and productive workforce of working women.
BLOCKCHAIN AND CRYPTOCURRENCY: A DOUBLE-EDGED SWORD FOR FINANCIAL INCLUSION AND REGULATION
Authors: Pawar Aarya
Published: June 2024

This chapter explores the transformative impact of cryptocurrencies and blockchain technology on finance. It delves into blockchain's decentralized ledger, disrupting industries and promoting financial inclusion. Examining cryptocurrencies like Bitcoin and Ethereum, it discusses their benefits, challenges, and the importance of comprehensive regulation. Real-world applications, regulatory challenges, and collaborative efforts are highlighted. Opportunities for regulatory organizations, including CBDCs, RegTech, and regulatory sandboxes, are discussed with examples. The chapter underscores the global significance of collaboration for establishing uniform regulatory frameworks for cryptocurrencies, providing a comprehensive overview of the evolving financial landscape.
THE FUTURE OF CHAT GPT IN INDIA AND ITS IMPACT ON THE INDIAN IT SECTOR
Authors: Chakraborty Devjeet
Published: June 2024

The rise of AI-powered conversational agents, such as GPT-3, has the potential to transform various industries, including the IT sector in India. This paper explores the development and future of Chat GPT technology and examines its implications for the Indian IT industry. The analysis considers potential applications, challenges, and opportunities arising from the integration of Chat GPT in Indian businesses, as well as its potential impact on the workforce and job market.
ARTIFICIAL INTELLIGENCE IN HUMAN RESOURCE MANAGEMENT
Authors: Devi Ms. Reena , Dahiya Dr. Jaspreet
Published: June 2024

kind of gap exists between the reality and promises of AI in the field of Human Resource Management and also it gives suggestions related to the progress which can be made for further improvements. Four challenges have been identified in HR practices while using the techniques of HR practices: • Restrictions which are been imposed by small type of data sets • Employee reaction to management via data based algorithms • Complexity of HR phenomena • Questions ethically related with the constraints of fairness and legal constraints We suggest practical solutions to these issues, focusing on the over lying three concepts – randomization, cognitive kind of reasoning and formalization of process which might prove efficient economically and appropriate socially for applying data analytics in the process of staff administration.
MEASURING SERVICE QUALITY ON EDUCATIONAL SERVICES: SERVQUAL MODEL FRAMEWORK
Authors: Sorathiya Dineshkumar Odhavajibhai , Patel Dr. Kinjal
Published: June 2024

By examining students' expectations and perceptions of the services offered, service quality measurement is one of the key measuring techniques or instruments used by educational institutions to comprehend students' needs and experiences. In order to identify the service variables in the educational sector, this study assesses the service quality of a university in Surat, Gujarat, India. At the educational institution, five specific dimensions—tangibles, reliability, responsiveness, assurance, and empathy—were looked at. A well-structured questionnaire was created, and SERVQUAL dimensions scales were modified for the purpose. The management and commerce students who made up the sampling units were asked about the expected and perceived quality of the services provided to them. Personal interviews were used to gather their thoughts. Students received a total of 120 questionnaires, 113 of which were deemed legitimate. The results of service gap analysis showed negative gaps for the assurance, reliability, and tangibles dimensions. To enhance service quality and raise student happiness, a few service solutions are suggested to the university.
ROLE OF DIGITAL TRANSFORMATION AND E-COMMERCE IN ENHANCING INTERNATIONAL BUSINESS
Authors: Jagirdar Dr. Abid Hussain
Published: June 2024

This research paper explores the significance of enhancing international business operations related to Digital Transformation and E-commerce. With globalization becoming an integral aspect of modern business, organizations are increasingly venturing into international markets to access new opportunities and expand their reach. Digital transformation and e-commerce have emerged as transformative forces in the realm of international business. The integration of digital technologies and the rise of online commerce have reshaped the way companies operate, connect with customers, and expand their global presence. This abstract explores the key aspects of digital transformation and e-commerce in the context of international business, highlighting their impact on communication, supply chain management, customer experience, and market reach. The growing significance of data-driven decision-making and the facilitation of cross-border transactions are discussed as critical drivers of success in the digital age. As companies continue to embrace these trends, their ability to navigate the ever-evolving global landscape is vital for achieving sustainable growth and competitive advantage. This abstract offers valuable insights into the dynamic relationship between digital transformation, e-commerce, and international business, underscoring the need for organizations to adapt to the opportunities and challenges presented by the digital revolution.
SERVANT LEADERSHIP: TRANSFORMATION IN LEADER’S APPROACH
Authors: Joshi Dr. Deepa
Published: June 2024

In India Servant Leadership was propounded several centuries back and the epic such as Ramayana and Mahabharata have given several instances which project ancient India has lived by example for the world regarding servant leadership. The study is descriptive in nature. Observations through the performance of leaders of various companies and countries are the basis of findings. Servant leadership leads employees to put an optimal effort in achieving the objectives of the organization as they feel included and valued. The study concludes that the transformation to servant leadership brings positive results for the employees in their individual capacity as well as in teams and ultimately for the organization.
RADIOPHARMACEUTICAL SCIENCE
Authors: Sharma Manvi , Agarwal Ena , Bansal Radhika , Tripathi Vishnu Kant
Published: June 2024

In today's advancing world, we as humans have undergone a varied change in our lifestyles. Due to that, we are more prone to certain ailments. To cope up with that, we invented medications and new technologies. One remarkable invention is the use of radioparticles. Using radioactive elements for diagnosis and treatment purposes paved the way for better healthcare system. The study of such combinations of physics, chemistry and biology in pharmaceuticals refers to Radiopharmaceutical Science. They are helpful in treating cancer, Thyroid etc. For better imaging and clear Identification of diseases they are also useful. One leading advantage of using radioparticles Is targeted therapy. Therefore, usage of Radioisotopes in pharmaceuticals is Proving to be beneficial to humans.
FUTURE TRENDS IN HERBAL COSMETICS CONTAINING SEVERAL INGREDIENTS
Authors: Sadasiv Sarukh Vikram , Vilas Supekar Amol , Sandip Khandagale , Saudar Saurabh , Sandip G. Badadhe Dr.
Published: June 2024

The concept of beauty products and cosmetics has origins dating back to ancient civilizations. Herbal ingredients are increasingly preferred over chemical compounds due to their accessibility and minimal side effects. The demand for herbal products and cosmetics is increasing due to concerns about health risks associated with synthetic components. Beyond their benefits of bioactive ingredients in cosmetics serve as antioxidants, anti-inflammatory agents, antiseptics, and antibacterials. Various herbal components are utilized in cosmetics to address skin and hair issues. Natural ingredients contribute to hair health by providing smoothness, shine, and treatments for conditions such as dandruff and alopecia. These active ingredients not only enhance skin appearance but also promote collagen growth and enrich the skin's texture by interacting with keratin structures and stimulating the generation of free radicals. Herbal elements offer essential minerals and nutrients, contributing to overall body enhancement. The herbal industry has experienced significant growth since ancient times. This chapter provides an overview of diverse herbal substances utilized in cosmetics.
CURRENT ANALYTICAL APPROACHES IN QUALITY EVALUATION OF MEDICINAL PLANTS
Authors: Salar Sapna , Ekbbal Rustam , Shamim Ms.
Published: June 2024

Medicinal plants have been used for centuries as a source of natural remedies for various ailments. However, ensuring the quality and efficacy of medicinal plants is crucial to guarantee their safety and therapeutic benefits. This review highlights the current analytical approaches employed in the quality evaluation of medicinal plants. The quality evaluation of medicinal plants involves the assessment of various parameters, including the identification of plant species, the determination of phytochemical constituents, and the quantification of bioactive compounds. Advanced analytical techniques such as chromatography (HPLC, TLC), spectroscopy (UV-Vis, FT-IR, NMR), and mass spectrometry (LC-MS, GC-MS) are extensively used for the qualitative and quantitative analysis of phytochemicals. Moreover, fingerprinting techniques, such as high-performance thin-layer chromatography (HPTLC) and high-performance liquid chromatography (HPLC), are employed to establish the chemical profiles of medicinal plants, ensuring their authenticity and consistency. Additionally, bioassays and pharmacological studies are conducted to assess the biological activities and therapeutic potential of medicinal plant extracts. The application of modern analytical techniques in quality evaluation allows for the detection of adulteration, contamination, and variability in medicinal plant samples. These techniques also facilitate the standardization of herbal medicines, ensuring batch-to-batch consistency and promoting their safe and effective use. In conclusion, current analytical approaches play a vital role in the quality evaluation of medicinal plants by providing accurate and reliable information regarding their chemical composition, authenticity, and therapeutic potential. These approaches contribute to the standardization and regulation of herbal medicines, thereby ensuring their quality, efficacy, and safety for consumers.
CANCER THERAPEUTIC TARGETS: AN OVERVIEW OF DIFFERENT TYPES OF PROTEASES
Authors: Archunan Govindaraju , Senthil Renganathan
Published: June 2024

In healthy cells, proteases play an important part in the execution of biological processes. Proteases and associated anti-proteases coexist in equilibrium in biological systems, and disruption of this balance results in a variety of illnesses, including cancer. Serine, cysteine, aspartate, threonine, and matrix metalloproteases are five different types of proteases that contribute to the progression of a tumor from its early stages through growth, metastasis, and eventually invasion into a new place. The term "cancer degradome" refers to a group of peptides' roles in the course of the disease. Multiple studies have demonstrated a correlation between the enzymatic activity of lysosomal cysteine proteases and tumorigenesis. Trypsin, a well-known digestive serine protease that promotes invasion, proliferation, and metastasis, has also been linked to a number of malignancies. The prognosis and length of disease-free life are poor for colorectal cancers that express trypsin. Protease inhibitors' usage in the treatment of cancer is suggested by the role of proteases in cancer. Protease inhibitor-based therapies and their impact in different carcinogenesis processes will be the emphasis of this chapter
MULTI-OMICS APPROACH FOR BIOMARKER DISCOVERY IN CANCER
Authors: Swain Amrita , Pradhan Anwesha , Jena Soumya Ranjan , Soren Dhananjay , Samanta Luna
Published: June 2024

Despite significant progress in the recent past, cancer remains as an enigma for both clinicians and scientists alike and the underlying mechanism(s) of onset and progression of the disease remain unresolved. Nevertheless, in recent years several efforts have been crafted for use of high through put omics technologies including genomics (detection of cancer- specific mutations across the genome), epigenomics (identification of modified epigenetic regulations within cancerous cells), transcriptomics (scrutinization of differential expression of mRNAs), proteomics (exploration of differentially expressed proteins) and metabolomics (comprehensive analysis of small metabolites) for unraveling reliable biomarkers for cancer. Isolated omics subset data may offer an incomplete, skewed and biased picture while integrating different omics techniques is likely to evaluate the cross-talk between various aspects of the complicated physiology of cancer initiation and development. Integration of multi-omics data from different molecular domains with clinical data and epidemiologic risk factors may provide a sensitive, accurate and reproducible technique for interpreting the intricacies of cancer. Hence, a detailed analysis of multiomics data in an integrated framework is hypothesized to accelerate identification of potential cancer biomarkers leading to timely diagnosis and prompt medical intervention in the field of precision medicine and is the major focus of this chapter.
INTRODUCTION TO MEDICAL HEALTH INFORMATICS: BRIDGING THE GAP BETWEEN MEDICINE AND TECHNOLOGY
Authors: Jonwal Harshita
Published: June 2024

Medical Health Informatics, the fusion of medicine and technology, has reshaped healthcare, improving how care is delivered and patients are treated. This exploration covers its various aspects: defining what it is, its history, why it matters, and what's coming in the future. Starting with a basic understanding, this abstract highlights how Medical Health Informatics fits into modern healthcare and introduces its main parts. It then dives deep into its history, showing how technology has changed how doctors work and how patients are looked after. Explaining why this matters, the abstract lists the benefits of Medical Health Informatics, like making patients safer and care better overall. It's about using technology to move healthcare forward.Inside hospitals and clinics, Electronic Health Records (EHRs) and systems that help manage patient information and images. It's about how tech can help healthcare be more organized. Bringing technology into the way doctors and nurses work is important, but it's not always easy. The chapter talks about the good parts and the challenges, and how it can also give patients a bigger role in their care. Keeping patient information safe is crucial, and also explains how technology and privacy rules work together. Ending with real examples, it shows how Medical Health Informatics has made a real difference in hospitals and clinics. It's a powerful way of using technology to make healthcare better. In short, this chapter covers everything about Medical Health Informatics – what it is, how it's changed healthcare, why it's important, and what's next. It's like a guide to understanding how technology and medicine come together to make healthcare better worldwide.
SYNTHETIC BIOLOGY
Authors: R Nandan , R Barade Srinivasan , C Dr. Soumya
Published: June 2024

Synthetic biology is often misunderstood to involve the creation of artificial life or new biological systems based on principles that differ from those of existing organisms in our environment. The main aim of synthetic biology is to speed up, reduce the cost, and make the engineering of biological systems more predictable, while adhering to secure and sound development guidelines. Synthetic biological circuits, which carry out the activities of sensing input, processing logic, and producing output functions, are central to designed organisms. By using the 'design, build, test, and learn' (DBTL) cycle from traditional engineering disciplines, these new systems are created. This DBTL cycle leads to the development of a product, or in the case of synthetic biology, an engineered biological system, at the highest level. This cycle includes defining the desired output, or what needs to be designed and created, predicting how to build the output using biological knowledge and principles, building computational models with applied machine learning, and biological design, testing the output of the design and build phases, and finally learning from observed results of the output and tweaking the process if necessary to run another cycle iteration.
BIODIESEL PRODUCTION FROM GROUNDNUT OIL, SESAME OIL AND COTTON OIL BY TRANSESTERIFICATION REACTION
Authors: Ghodadra Kajal , Vyas Suhas
Published: June 2024

The present study is to get high yield of fuel which are utilise as energy resources. Energy resources are renewable and non-renewable so as a solution of shortage of fossil fuel in future production of non-renewable energy source biodiesel, which is another helpful energy source like hydropower, wind and solar energy. And it works as fossil fuel without harm environment. Sources of biodiesel are petro crops, it’s seed oil have characteristics of fuel. Petro crops mostly included Jatropha Spp. and algal species can be convert into biofuel or synthetic Petroleum. This research shows different experiments of biodiesel production from groundnut oil sesame oil and cotton oil.in the modified transcrification method different amounts of methanol or NaOH used in the reaction, it affects directly to production rate it gives 2 to 3% less production compared to normal method. groundnut and cotton oil alternate its density after converting into biodiesel. sesame oil density is not change after converting into biodiesel,conclusion is groundnut biodiesel and cotton biodiesel's quantity is 6 to 7% better than its oil formHence, now these oil have more characteristics of the biodiesel as compared to sesame biodiesel. Sesame oil and biodiesel both are remain same. so it has less characteristics of biodiesel.
PREFABRICATED BUILDING CONSTRUCTION: A THEMATIC ANALYSIS APPROACH
Authors: Sharma Shashikant Nishant , Dehalwar Dr. Kavita , Lodhi Arjun Singh , Kumar Gopal
Published: June 2024

The study uses a comprehensive search strategy to identify relevant studies, including peer-reviewed articles, conference proceedings, and technical reports. A total of 42 studies were selected for inclusion in the review, and their findings are synthesized using a thematic analysis approach. Prefabrication building construction is an emerging trend in the Indian construction industry. This paper aims to provide an overview of prefabrication technology and its use in building construction in India. The benefits and challenges of prefabrication, as well as the factors that influence its adoption in India, are discussed. The paper also provides an overview of the current state of the prefabrication industry in India, and the key players in the market. Finally, the paper highlights successful prefabrication projects in India and concludes that prefabrication technology has the potential to revolutionize the construction industry in India and address some of its key challenges
CLIMATE RESPONSIVE DESIGN METHODS: CASE OF INDIAN INSTITUTE OF SCIENTIFIC RESEARCH AND EDUCATION, BHOPAL, MADHYA PRADESH, INDIA
Authors: Kaur Mr. Manmeet
Published: June 2024

Over the past few decades, Climate change have created adverse impacts on environment where construction industry is one of the major contributors. According to a report generated by World Economic Forum in February 2022, buildings are contributing 40% of emissions globally. Therefore, it is a high time to adopt climate responsive design methods. It is extremely important to analyze different scales of climate in a region in the early phase of architectural design process and design accordingly. The climate should always be studied at three levels which includes macro-climate, meso-climate and micro-climate for in-depth understanding of climatic phenomena. Hence, this paper identifies the climate responsive design approaches for design of building clustersin institutional campuses with the case example of Indian Institute of Scientific Education and Research, Bhopal at all the three levels of climate. Microclimate analysis of the campus have been discussed in detail with the help of wind flow regimes between buildings , shadow analysis and topographic analysis including relief , slope , aspect and landform maps. The paper concludes with comprehensive landscape development solutions after identifying the issues from the analysis and adequate positioning of buildings with respect to each other to design with climate.
MECHANISM AND ANN MODELING OF SULFATE-INDUCED HEAVE IN NON-SWELLING SOIL IN AN ACIDIC ENVIRONMENT
Authors: B Guru Prasad.
Published: June 2024

Red earth (aluminosilicate) is mainly comprised of kaolinite mineral, which is of non-swelling in nature. The iron oxides present in the soil impart red colour to the earth, hence it is named red earth. In the case of natural 1:1 minerals, no significant volume changes are observed due to strong hydrogen bonding between their interlayers. Sulfate in an acidic environment can cause abnormal volume changes in natural red earth, owing to mineralogical alterations. Sulfuric acid solutions of varying concentrations are used to induce sulfate content in an acidic environment, which is a very common cause of acid sulfate soil contamination. When sulfuric acid starts interaction with red earth, the hydrated hydrogen ion starts attacking (due to smaller in size and/or ionic potential) on the red earth leading to a reduction in H-bonding between successive basic units of kaolinite and releasing the iron from iron oxides, results in the formation of new mineral rozenite (iron sulfate hydrate) in combination with sulfates. During this process, the heave reported in the red earth at nominal surcharge continued for a long period indicating that the formation of minerals was a rather slow process. The observed heave after considerable time lag, unlike the swell that occurs due to the adsorption of water by clay particles. The formation of new minerals is responsible for the observed non-hyperbolic nature of time swell relationships and the mineralogical and morphological changes are confirmed by scanning electron microscopy and energy dispersive analysis of X-ray studies. Besides, the sulfate-induced time-dependent swell percent in red earth in an acidic environment is studied by employing the Artificial Neural Network model with Levenberg–Marquardt (LM) algorithm. The network was programmed using MATLAB® code to process the information and predict the percent swell at any time, knowing the variable involved. Eight basic soil and fluid parameters were used as input feed to predict the percent swell to the proposed network. The study demonstrates that it is possible to develop a general ANN model that can predict time-dependent swell in sulfate-induced red earth with relatively high accuracy with observed data (R2 = 0.9986). The investigation results demonstrate reference to the engineering behaviour of acid sulfate soils, distributed worldwide under acidic environments.
SMART MATERIALS IN CONSTRUCTION
Authors: J Anitha
Published: June 2024

Smart materials, which respond to external stimuli such as temperature, light, stress, or magnetic fields, have gained significant prominence in civil engineering. This paper examines the development of smart materials and their applications in construction, with a focus on Shape Memory Alloys (SMAs), Piezoelectric Materials, Self-Healing Concrete, Shape-Shifting Polymers, Smart Sensors, Magnetorheological Fluids, Photochromic and Thermochromic Materials, and Carbon Fiber Reinforced Polymers (CFRPs). The paper explains, • The temperature-dependent phases of SMAs and their stress-temperature relationship. • The types, advantages, and limitations of piezoelectric materials, emphasizing their diverse applications in construction. • Applications, advantages, and disadvantages of self-healing concrete in various construction scenarios. • Applications of Shape Memory Polymers (SMPs)in adaptive architecture for self-regulating systems, emphasizing their properties, applications, and limitations. • Applications of smart sensors in construction, highlighting their role in real-time monitoring, safety, and resource utilization. • Potential of Photochromic and Thermochromic Materials in architectural applications for dynamic light and temperature control. • Properties, applications, advantages, and limitations of CFRPs in enhancing structural robustness. This comprehensive overview aims to provide insights into the diverse applications of smart materials in civil engineering, paving the way for innovative and resilient construction practices
A COMPARATIVE STUDY OF STOCK PRICE PREDICTION USING ARIMA - LSTM TIME SERIES MODELS
Authors: Ashok Pappula , Reddy Dr D. Mallikarjuna
Published: June 2024

Time series prediction is incredibly important and difficult; external factors can also affect prediction results. Therefore, this study compares the following two models to see which makes better predictions. The traditional model is the "Autoregressive Integrated Moving Average" (ARIMA). Over time, new variables like SRIMA (seasonal ARIMA) have emerged. This model is better for short-term prediction than long-term prediction. Another model, CNN and RNN, is more dependent on artificial intelligence data analysis and closer to upcoming technologies. This research focuses on LSTM neural networks, which can learn from historical data and relate to present data. According to this paper's data, LSTM's data prediction is superior to the ARIMA model.
A PORTRAYAL OF INTEGER SOLUTIONS TO NON-HOMOGENEOUS TERNARY CUBIC DIOPHANTINE EQUATION
Authors: Shanthi J. , Gopalan M. A.
Published: June 2024

This paper is concerned with the problem of determining varieties of non-zero distinct integer solutions to the non-homogeneous ternary cubic diophantine equation; Different sets of integer solutions to the above equation are obtained by reducing it to the equation, which is solvable, through employing suitable transformations.
EFFECT OF ROTATION AND FLR CORRECTIONS ON LONGITUDINAL THERMAL INSTABILITY OF FINITELY CONDUCTING RADIATIVE POROUS PLASMA IN INTERSTELLAR MEDIUM (ISM)
Authors: Mishra Sarvesh , Kaothekar Sachin , Phadke Sushil
Published: June 2024

The impact of rotation, finite ion Larmor radius (FLR) corrections and porosity on the thermal instability of infinite homogeneous plasma has been discovered incorporating the outcomes of radiative heat-loss function and thermal conductivity. The dispersion relation is obtained by resources of the normal mode analysis method with the assist of suitable linearized perturbation equations of the difficulty. This dispersion relation is supplementary decreases for rotation axis parallel and perpendicular to the magnetic field. Thermal instability condition founded the stability of the system. Arithmetical calculations have been implemented to represent the effect of various constraints on the growth rate of the thermal instability. We find that rotation, FLR corrections and medium porosity stabilize the growth rate of the system in longitudinal mode of propagation. Our outcome demonstrates that the rotation, porosity and FLR corrections influence the dens molecular clouds configuration and star formation in interstellar medium.