bluuebunny/crossref_metadata_2025 huggingface dataset:
Konsep Tabayyun menurut Buya HAMKA dan Implementasinya pada Praktikum Kimia di Rumah (Studi Kasus Berita Hoaks COVID-19)
Authors: Prastyo Budiman , Ashari Muhammad Akmal , Marhan Marhan
Published: October 2020

Berita hoaks di Indonesia jumlahnya relatif banyak. Sejumlah 850 hoaks oleh Kementerian Komunikasi dan Informatika dari Januari-Juni 2020. Di samping itu, riset mengenai COVID-19 di dunia ini relatif banyak. Hal ini dinilai telah terjadi kesenjangan informasi mengenai riset COVID-19, sehingga munculnya berita hoaks. Penelitian bertujuan untuk mengetahui makna tabayyun menurut Buya Hamka menurut QS. Al-Hujurat [49]: 6, kemudian diimplementasikan melalui praktikum kimia guna mengklarifikasi adanya berita hoaks. Metode dalam penelitian ini adalah studi pustaka. Sumber primer yang digunakan yaitu tafsir Al-Azhar, sedangkan sumber sekunder didapatkan dari buku, majalah dan artikel jurnal yang menunjang penelitian. Dari hasil penelusuran terhadap penafsiran Hamka dan responnya sebagai sikap tabayyun, didapatkan langkah implementasi praktikum kimia, yaitu: (1) Tahapan penerimaan berita; (2) Tahapan pelaksanaan praktikum dan (3) Tahapan tanggapan dan evaluasi.
Storm Water Sustainable Solutions in New Cairo Using Landscape Elements
Authors: El-Gohary Germin , Alshnawi Omar , Mohamed Sherouk
Published: October 2020

Sustainability is one of the most important requirements and standards that is taken into consideration when establishing or developing a project. It is necessary to pay sufficient attention to urban planning and study. This involves a structured form of the city and the establishment of its own cities, connecting them with different communities, providing all social and economic services for the population as well as improving the performance of the city in accordance with international standards of urban planning.Storm water is the water that remains after rain, melted snow or floods. The effects of storm water is devastating on the environment, the economy and the social environment, especially in cities. In New Cairo, this problem is still ongoing with no implemented solution and receiving insufficient attention. New Cairo has faced the risk of flooding and major traffic disruptions in most of its main roads in 2018.In this research, an attempt is made to arrive at a merger between the elements of the Landscape and the infrastructure to find sustainable solutions. This solution can limit or prevent the existence of storm water problems and discusses the possibility of developing existing cities that have problems.This will be done through analysis, study of the problem, analysis of the case study and the soil, study the elements of the Landscape. Take in consideration that the data is up to date and the solution is possible to implement to solve the problem.
Mineral nutrition of buckwheat in fluoride polluted soil: case study in pot experiment
Authors: Pavlova Olga , Litvinovich Andrey , Lavrishchev Anton , Bure Vladimir , Saljnikov Elmira
Published: October 2020

The research aimed to establish an optimal and safe level of mineral nutrition for buckwheat grown in the fluoride contaminated soil by defining yield and chemical composition of buckwheat grown on acidic soddy-podzolic soil under different levels of fertilization, and assessing the possibility of reducing fluoride phytotoxicity. The mechanisms of plant uptake of fluoride may be influenced by interaction in nutrient uptake by plant. Sodium fluoride solution was applied at the rate of 100 mg per 1 kg of soil mass. Two different experiments were studied under controlled conditions: the first experiment with increasing doses of ammonium nitrate, and the second experiment with increasing doses of orthophosphoric acid. Increase of N fertilization resulted in an increase in the concentration of fluoride in the tissues of buckwheat and lowers yields of plants, while application of P reduced uptake of fluoride and increased productivity of buckwheat. In fluoride contaminated soil the chemical composition of buckwheat was affected by synergism and antagonism of individual elements during absorption by plants. A protective mechanism of buckwheat against negative effect of fluoride was due to its ability to activate metabolism regulating the flow of individual elements in tissue that reduces the adverse impact of pollutant.
Brown bullhead Ameiurus nebulosus — new fish species for Russia
Authors: Popov Igor , Kotova Anna
Published: October 2020

The native habitat of the brown bullhead Ameiurus nebulosus is located in the eastern part of North America. This species was introduced in Europe, Southwestern Asia and New Zealand. It was supposed that it entered Russia from the southwest and now inhabits some water bodies at the border with Ukraine and Belarus. Information about bullheads in Russia was searched for in scientific editions and angler’s blogs. Anglers’ reports have been verified by survey and fishing. It turned out that brown bullheads did in fact appear in Russia, but not where they were expected: they were found by the city of Saint Petersburg on the Karelian Isthmus, i.e., on the territory between Lake Ladoga and the Gulf of Finland of the Baltic Sea. They inhabit at least three lakes. This invasion resulted from release by unauthorized individuals. The revealed habitats are linked by brooks with the river systems of the Baltic Sea Basin. The following spread of the brown bullhead is possible due to intentional releases and natural processes.
Features of hemodynamics of pulmonary circulation during the diving reflex
Authors: Podyacheva Ekaterina , Zemlyanukhina Tatyana , Shadrin Lavrentij , Baranova Tatyana
Published: October 2020

The adaptive cardiovascular reactions of the human diving reflex were studied. The diving reflex was activated by submerging a face in cold water under laboratory conditions. Forty volunteers (aged 18–24) were examined. ECG, arterial blood pressure (ABP) and central blood flow were recorded by the impedance rheography method in resting state, during diving simulation (DS) and after apnea. During DS there is a statistically significant decrease in the dicrotic index (DCI), which reflects a decrease in the resistive vessel tone and as well as diastolic index (DSI), characterizing lung perfusion. A comparison of the latent periods (LP) of an increase in ABP and a drop in DCI showed that a decrease in pulmonary vascular tone develops faster than ABP begins to increase. The LP for lowering DCI is from 0.6 to 10 s; for an increase in ABP — from 6 to 30 s. A short LP for DCI and the absence of a correlation between a decrease in ABP and DCI suggests that a decrease in pulmonary vascular tone during DS occurs reflexively and independently of a change in ABP.
A hierarchy of compass systems in migratory birds
Authors: Pakhomov Alexander , Chernetsov Nikita
Published: October 2020

Migratory birds use several different sources of orientation information. They have at least three compass systems based on different cues: the sun and polarized light, the stars and their constellations, and the geomagnetic field. The concurrent information obtained from these three compasses is redundant, therefore the compasses need to have a hierarchy and must be calibrated relative to each other. One of the compasses should dominate the others, or some orientation cue should be used to calibrate the remaining compass systems. Results of experiments on a variety of songbird species demonstrate that while astronomical cues calibrate the magnetic compass during the pre-migratory period, strategies used during the migratory period are more diverse. In the present review, we analyze the results of all crucial cue-conflict studies, mostly performed in nocturnal songbird migrants; we also try to understand why some migratory species calibrate their magnetic compass on sunset cues while others use the geomagnetic field or stars as a primary cue source, and we examine why the previous hypothesis could not explain the findings of all cue-conflict experiments.
Accessibility of Rural Tourism Services for the Disabled in Lithuania
Authors: Juodisius Mantas , Uspuriene Aiste Barbora
Published: October 2020

Rural tourism has great potential for attracting people with different interests, but it requires close cooperation in the planning and implementation of strategic development directions and measures related to tourism. At present time, the social model of integration of the disabled is becoming more and more established. A person with a disability needs adapted infrastructure to travel. Actions should be implemented in accordance with the principle that people with disabilities, like all people, need access and integration. Therefore, it is important to study the accessibility of rural tourism services for the disabled in Lithuania.
An Overview of the One-pot Synthesis of Imidazolines
Authors: Aneeja Thaipparambil , Radhika Sankaran , Neetha Mohan , Anilkumar Gopinathan
Published: October 2020

One-pot syntheses are a simple, efficient and easy methodology, which are widely
used for the synthesis of organic compounds. Imidazoline is a valuable heterocyclic moiety
used as a synthetic intermediate, chiral auxiliary, chiral catalyst and a ligand for asymmetric
catalysis. Imidazole is a fundamental unit of biomolecules that can be easily prepared from
imidazolines. The one-pot method is an impressive approach to synthesize organic compounds
as it minimizes the reaction time, separation procedures, and ecological impact. Many significant
one-pot methods such as N-bromosuccinimide mediated reaction, ring-opening of tetrahydrofuran,
triflic anhydrate mediated reaction, etc. were reported for imidazoline synthesis.
This review describes an overview of the one-pot synthesis of imidazolines and covers literature
up to 2020.
Cyclotriphosphazene-based Derivatives for Antibacterial Applications: An Update on Recent Advances
Authors: Su Xiqi , Wang Le , Xie JingHua , Liu XiaoHui , Tomás Helena
Published: October 2020

As a phosphorus scaffold, hexachlorocyclotriphosphazene (HCCP) is widely used
for the synthesis of varieties of derivatives, including metal-binding complexes and several
unique organometallic compounds, which exhibit potential catalytic, flame retardant and biological
activities. Some metal-binding HCCP derivatives have shown antibacterial activities as
free ligands and metal complexes. These derivatives can also serve as building blocks for the
formation of antibacterial metal-containing polymers. This mini-review is focused on the design
and development of HCCP derivatives as potential antibacterial agents with representative
examples as well as antibacterial mechanisms from recent years.
Analysis of Chinese Herbal Formulae Recommended for COVID-19 in Different Schemes in China: A Data Mining Approach
Authors: Yin LiWei , Gao YaCen , Li ZiPing , Wang MengYu , Chen KaiXin
Published: October 2020

Background:

Novel coronavirus pneumonia (NCP), or coronavirus disease 2019
(COVID-19), is a worldwide health threat that has affected millions of people globally. Traditional
Chinese medicine (TCM) has been introduced for the treatment of COVID-19. However, efficacy
differs among herbal medicines, and the ideal prescription pattern for TCM herbal formulae for
COVID-19 treatment needs to be explored. Therefore, the data mining method has been used in
this study to analyze the TCM prescription pattern for COVID-19.

Objective:

The aim of this study was to analyze the TCM prescription pattern in Regional Schemes
in China for COVID-19 in order to provide a new reference for the use of TCM in COVID-19 treatment.

Methods:

By searching the TCM treatment protocols of COVID-19 in 23 Regional Schemes, TCM
syndromes and herbal medicines were analyzed by data mining. The Ancient and Modern Medical
Case Cloud Platform (V2.1 personal Edition) was used to perform frequency statistics, correlation
analysis, and cluster analysis. A total of 82 TCM syndromes and 171 Chinese herbal medicines
were found. The course of the disease can be divided into the early stage, middle stage, severe
stage, and recovery stage.

Results:

In the early stage, the focus is primarily on resolving dampness, dispelling cold, and diffusing
the lungs. In the middle stage, the treatment priority is clearing heat and resolving toxins,
promoting lung function, and relieving asthma. In the severe stage, the focus is on tonifying Qi, restoring
Yang, and relieving the depletion of Yin and Yang. In the recovery stage, the main treatment
is to invigorate the spleen and regulate Qi, tonify Qi, nourish Yin, and clear residual disease. There
are certain differences between the Regional Schemes and the Nation Schemes, but the core prescription
pattern of the former is consistent with the latter. The effectiveness of these 171 Chinese
herbs include but are not limited to inhibiting COVID-19, strengthening immune system function,
preventing heart failure, acting as antioxidants, oxidative stress inhibitory effects, maintaining organ
function, and improving leukocyte survival.

Conclusion:

This study may help to improve understanding of TCM herbal prescription pattern,
practices, reveal the efficacy of combinations of Chinese herbs, and provide new ideas for TCM
treatment for COVID-19.
An Agathokakological Tale of Δ9-THC: Exploration of Possible Biological Targets
Authors: Mathew Bijo , Harilal Seetha , Musa Arafa , Kumar Rajesh , Parambi Della Grace Thomas , Jose Jobin , Uddin Md. Sahab , Shah Muhammad Ajmal , Behl Tapan , Unnikrishnan Mazhuvancherry Kesavan
Published: October 2020

Δ9-Tetrahydrocannabinol (Δ9-THC), the active phytocannabinoid in cannabis, is virtually
an adjunct to the endogenous endocannabinoid signaling system. By interacting with G-proteincoupled
receptors CB1 and CB2, Δ9-THC affects peripheral and central circulation by lowering
sympathetic activity, altering gene expression, cell proliferation, and differentiation, decreasing
leukocyte migration, modulating neurotransmitter release, thereby modulating cardiovascular functioning,
tumorigenesis, immune responses, behavioral and locomotory activities. Δ9-THC effectively
suppresses chemotherapy-induced vomiting, retards malignant tumor growth, inhibits metastasis,
and promotes apoptosis. Other mechanisms involved are targeting cell cycle at the G2-M phase
in human breast cancer, downregulation of E2F transcription factor 1 (E2F1) in human glioblastoma
multiforme, and stimulation of ER stress-induced autophagy. Δ9-THC also plays a role in ameliorating
neuroinflammation, excitotoxicity, neuroplasticity, trauma, and stroke and is associated
with reliving childhood epilepsy, brain trauma, and neurodegenerative diseases. Δ9-THC via CB1
receptors affects nociception, emotion, memory, and reduces neuronal excitability and excitotoxicity
in epilepsy. It also increases renal blood flow, reduces intraocular pressure via a sympathetic
pathway, and modulates hormonal release, thereby decreasing the reproductive function and increasing
glucose metabolism. Versatile medical marijuana has stimulated abundant research demonstrating
substantial therapeutic promise, suggesting the possibilities of first-in-class drugs in diverse
therapeutic segments. This review represents the current pharmacological status of the phytocannabinoid,
Δ9-THC, and synthetic analogs in cancer, cardiovascular, and neurodegenerative disorders.
Tumor Penetrating Peptide-Functionalized Tenascin-C Antibody for Glioblastoma Targeting
Authors: Lingasamy Prakash , Laarmann Anett-Hildegard , Teesalu Tambet
Published: October 2020

Background:

Conjugation to clinical-grade tumor penetrating iRGD peptide is a widely
used strategy to improve tumor homing, extravasation, and penetration of cancer drugs and tumor
imaging agents. The C domain of the extracellular matrix molecule Tenascin-C (TNC-C) is upregulated
in solid tumors and represents an attractive target for clinical-grade single-chain antibody-
based vehicles for tumor delivery drugs and imaging agents.

Objective:

To study the effect of C-terminal genetic fusion of the iRGD peptide to recombinant anti-
TNC-C single-chain antibody clone G11 on systemic tumor homing and extravasation.

Methods:

Enzyme-linked immunosorbent assay was used to study the interaction of parental and
iRGD-fused anti-TNC-C single-chain antibodies with C domain of tenascin-C and αVβ3 integrins.
For systemic homing studies, fluorescein-labeled ScFV G11-iRGD and ScFV G11 antibodies were
administered in U87-MG glioblastoma xenograft mice, and their biodistribution was studied by
confocal imaging of tissue sections stained with markers of blood vessels and Tenascin C immunoreactivity.

Results:

In a cell-free system, iRGD fusion to ScFV G11 conferred the antibody has a robust ability
to bind αVβ3 integrins. The fluorescein labeling of ScFV G11-iRGD did not affect its target
binding activity. In U87-MG mice, iRGD fusion to ScFV G11 antibodies improved their homing to
tumor blood vessels, extravasation, and penetration of tumor parenchyma.

Conclusion:

The genetic fusion of iRGD tumor penetrating peptide to non-internalizing affinity targeting
ligands may improve their tumor tropism and parenchymal penetration for more efficient delivery
of imaging and therapeutic agents into solid tumor lesions.
Expanding Opportunities in Treatment of Leukemia by Solid Lipid Nanoparticles
Authors: Yadav Prarthna , Mishra Harshita , Nagpal Manju , Aggarwal Geeta
Published: October 2020

Background:

Leukemia is a severe type of blood cancer that involves an abnormal proliferation of blood-forming cells. Its conventional treatment faces many challenges, including resistance, lack of specificity and high unwanted toxicity of drugs. Nano drug delivery systems help in overcoming these challenges by delivering the drug to the target site actively or passively. Solid lipid nanoparticles are gaining popularity because they reduce unwanted toxicity, are biocompatible, increase bioavailability and are versatile in terms of incorporated agents (hydrophilic as well as lipophilic drugs, genes, enzymes, etc.).

Purpose:

The aim of this review is to discuss recent advancements in anti-leukemic therapy utilizing solid lipid nanoparticles (SLNs) as successful carriers in enhancing the efficiency of the treatment and bioavailability of the incorporated drug along with overcoming multidrug resistance.

Methods:

This review represents the existing literature on the applications of SLNs in anti-leukemic therapy. A qualitative literature review has been performed for this purpose. We performed keyword research in popular databases such as Google Scholar, Wiley, Elsevier, Scopus, Google patent and PubMed. Only articles published in English and from reputed journals from specific fields were considered. Benchmark studies having major importance from 2000 to 2020 were selected to follow the progress in the field across the globe.

Results:

This article improves the understanding of the role of SLNs in the treatment of leukemia. Traditional anti-leukemic therapy involves many challenges, including resistance, lack of specificity and high unwanted toxicity of drugs. SLNs are emerging as a better alternative to conventional delivery systems as they can reduce unwanted toxicity, are biocompatible, and can provide active as well as passive molecular targeting.

Conclusion:

SLNs provide several advantages in drug delivery for leukemia, including enhancement of efficiency and bioavailability and reduction of toxicity by virtue of their small size, lipid core, non-dependency on organic solvents and versatility in terms of incorporated drugs.
COVID-19: Update on Pathogenesis and Treatment Strategies
Authors: Chauhan Rakesh K. , Sharma Pramod K. , Srivastava Shikha
Published: October 2020

COVID-19 (Coronavirus disease) is the most contagious virus, which has been characterized
as a global pandemic by WHO. The pathological cycle of COVID-19 virus can be specified as
RNAaemia, severe pneumonia, along with the Ground-glass opacity (GGO), and acute cardiac injury.
The S protein of Coronavirus has been reported to be involved in the entry of the virus into
the host cell, which can be accomplished by direct membrane fusion between the virus and plasma
membrane. In the endoplasmic reticulum or Golgi membrane, the newly formed enveloped glycoproteins
are introduced. The spread of disease occurs due to contact and droplets unleashed by the
vesicles holding the virus particles combined with the plasma membrane to the virus released by
the host. The present manuscript describes the pathogenesis of COVID-19 and various treatment
strategies that include drugs such as chloroquine and hydroxychloroquine, an anti-malarial drug,
antibodies: SARS-CoV-specific human monoclonal antibody CR3022 and plasma treatment facilitate
the therapeutic effect.
Application of Microbial Transglutaminase in Wheat Bread Industry: A Review
Authors: Meybodi Neda M. , Mirmoghtadaie Leila , Sheidaei Zhaleh , Arab Masoumeh , Nasab Sarah S. , Taslikh Musarreza , Mortazavian Amir M.
Published: October 2020

Bread as the main food all over the world is generally based on wheat flour due to its
unique properties to form a three-dimensional gluten network. In fact, the quality of bread is influenced
by wheat gluten quality and quantity. The quality of gluten protein is mainly defined based
on its amino acids composition and bonding (covalent and non-covalent). Gluten protein quality is
considered weak based on its essential amino acid content: lysine and threonine. Covalent crosslinks
as the main factor in determining the integrity of the gluten network are also interrupted by
the activity of proteolytic enzymes and reducing agents. Different treatments (physical, chemical
and enzymatic) are used to alleviate these detrimental effects and improve the bread making quality
of wheat flour. Given that, food industry is looking for using enzymes (respecting their specificity,
ease of use and low risk of toxic products formation) microbial transglutaminase is an efficient
option, considering its ability to introduce new crosslinks. This new crosslink formation can either
improve gluten protein quality in damaged wheat flour or imitate the function of gluten protein in
gluten free bread. The aim of this article is to review the application of microbial transglutaminase
enzyme as an improving agent in wheat bread industry.
Prevalence of Breast Complaints in Women with Mastopathy in Khorramabad
Authors: Ahmadinejad Mojtaba , Zarei Farshad
Published: October 2020

Background:

Evaluation and screening of breast cancer demand significant primary care practice. Breast pain
and nipple discharge are the frequent complaints owing to the benign conditions. Objective: In this study, we have
investigated the prevalence of breast complaints among women referred to our clinic in Khorramabad, Iran.

Methods:

This is a cross-sectional study about the prevalence of breast-related complaints in women with breast problems
referred to surgery clinic over a period 6 months.

Results:

Among 151 patients, following outcomes were seen; breast pain (60.3%), lump (27.8%), nipple discharge (4%),
lump with pain (4.6%) and other (0.7%). 11 patients were presented lump malignancy (23.9%) including; fibrocystic
change (56.5%) and fibro-adenoma (19.6%).

Conclusion:

This study showed that breast pain was the most common of all complaints and fibrocystic change was the
most detected lump-type. Lumps were frequent in single women whereas, mastalgia in common in married women.
Effect of Kegel Exercises on Pelvic Floor Muscle Disorders in Prenatal and Postnatal Women - A Literature Review
Authors: Torgbenu Eric Lawer , Aimakhu Christopher O. , Morhe Emmanuel Komla Senanu
Published: October 2020

Background:

Pelvic floor disorders affect many women globally.

Objective:

To provide a critical appraisal of the literature on the effects of pelvic floor disorders on
the quality of life and functioning of pregnant and postnatal women.

Methods:

Available literature was reviewed and summarized to discuss the definitions, pelvic floor
anatomy, dysfunctions, and the mechanism of the condition, and more specifically, on the strengthening
exercises for the pelvic floor muscles.

Results:

Pelvic floor disorder is an important public health concern because of the high prevalence,
deleterious effects on pregnancy, and its outcomes as well as impacts on the health care system.
They include genuine urinary incontinence, bladder and bowel incontinence, pelvic pain, weakness
of the pelvic muscles, weakness of the muscles of the core stability, and the prolapse of pelvic organs.
Pregnancy and subsequent vaginal delivery are causes associated with pelvic floor muscle
disorders. Approximately 60% and 50% of community settlers and residents of nursing homes respectively
are affected by urinary incontinence and the numbers increase with hysterectomy. Multiple
birth, obesity, chronic coughs, overweight babies, and heavy lifting are associated with risk
factors. Treatment of pelvic floor muscle disorders should involve an increased physical activity
prescription among women diagnosed with weaker pelvic floor muscles, engaging the multidisciplinary
team, increasing the quality of life and functioning of women during and after pregnancy.
Training aimed at strengthening the pelvic floor muscles is beneficial and prevents dysfunctions.

Conclusion:

Structured and well organised pelvic floor muscle training regimen, also known as
Kegel exercises, is important in preventing disorders of the pelvic floor during pregnancy and after
delivery.
Extracellular Vesicles Isolated from Mesenchymal Stromal Cells Primed with Hypoxia: Novel Strategy in Regenerative Medicine
Authors: Pendse Shalmali , Kale Vaijayanti , Vaidya Anuradha
Published: October 2020

Mesenchymal stromal cells (MSCs) regulate other cell types through a strong paracrine
component called the secretome, comprising several bioactive entities. The composition of the
MSCs’ secretome is dependent upon the microenvironment in which they thrive, and hence, it
could be altered by pre-conditioning the MSCs during in vitro culture. The primary aim of this review
is to discuss various strategies that are being used for the pre-conditioning of MSCs, also
known as “priming of MSCs”, in the context of improving their therapeutic potential. Several
studies have underscored the importance of extracellular vesicles (EVs) derived from primed
MSCs in improving their efficacy for the treatment of various diseases. We have previously shown
that co-culturing hematopoietic stem cells (HSCs) with hypoxia-primed MSCs improves their engraftment
potential. Now the question we pose is, would priming of MSCs with hypoxia favorably
alter their secretome? and would this altered secretome work as effectively as the cell to cell contact
did? Here we review the current strategies of using the secretome, specifically the EVs (microvesicles
and exosomes), collected from the primed MSCs with the intention of expanding HSCs
ex vivo. We speculate that effective priming of MSCs in vitro could modulate the molecular profile
of their secretome, which could eventually be used as a cell-free biologic in clinical settings.
Atrial Fibrillation and Ventricular Tachyarrhythmias: Advancements for Better Outcomes
Authors: Gheini Alireza , Pourya Afsoun , Pooria Ali
Published: October 2020

Cardiac arrhythmias are associated with several cardiac diseases and are prevalent in
people with or without structural and valvular abnormalities. Ventricular arrhythmias (VA) can be
life threating and their onset require immediate medical attention. Similarly, atrial fibrillation and
flutter lead to stroke, heart failure and even death. Optimal treatment of VA is variable and
depends on the medical condition associated with the rhythm disorder (which includes reversible
causes such as myocardial ischemia or pro-arrhythmic drugs). While an implanted cardioverter
defibrillator is often indicated in secondary prevention of VA. This review highlights the newest
advancements in these techniques and management of ventricular and atrial tachyarrhythmias,
along with pharmacological therapy.
Updated Understanding of Platelets in Thrombosis and Hemostasis: The Roles of Integrin PSI Domains and their Potential as Therapeutic Targets
Authors: MacKeigan Daniel T. , Ni Tiffany , Shen Chuanbin , Stratton Tyler W. , Ma Wenjing , Zhu Guangheng , Bhoria Preeti , Ni Heyu
Published: October 2020

Platelets are small blood cells known primarily for their ability to adhere and aggregate at injured vessels to arrest bleeding. However, when triggered under pathological conditions, the same adaptive mechanism of platelet adhesion and aggregation may cause thrombosis, a primary cause of heart attack and stroke. Over recent decades, research has made considerable progress in uncovering the intricate and dynamic interactions that regulate these processes. Integrins are heterodimeric cell surface receptors expressed on all metazoan cells that facilitate cell adhesion, movement, and signaling, to drive biological and pathological processes such as thrombosis and hemostasis. Recently, our group discovered that the plexin-semaphorin-integrin (PSI) domains of the integrin β subunits exert endogenous thiol isomerase activity derived from their two highly conserved CXXC active site motifs. Given the importance of redox reactions in integrin activation and its location in the knee region, this PSI domain activity may be critically involved in facilitating the interconversions between integrin conformations. Our monoclonal antibodies against the β3 PSI domain inhibited its thiol isomerase activity and proportionally attenuated fibrinogen binding and platelet aggregation. Notably, these antibodies inhibited thrombosis without significantly impairing hemostasis or causing platelet clearance. In this review, we will update mechanisms of thrombosis and hemostasis, including platelet versatilities and immune-mediated thrombocytopenia, discuss critical contributions of the newly discovered PSI domain thiol isomerase activity, and its potential as a novel target for anti-thrombotic therapies and beyond.
Role of Sm3+ Doping on Structural, Optical and Photoluminescence Properties of ZnO Nanoparticles Synthesized by Sol-gel Auto- combustion Method
Authors: Naik Eshwara I. , Naik Halehatty S.B. , Viswanath Ranganaik
Published: October 2020

Background:

Various interesting consequences are reported on structural,
optical, and photoluminescence properties of Zn1-xSmxO (x=0, 0.01, 0.03
and 0.05) nanoparticles synthesized by sol-gel auto-combustion route.

Objective:

This study aimed to examine the effects of Sm3+-doping on structural
and photoluminescence properties of ZnO nanoparticles.

Methods:

Zn1-xSmxO (x=0, 0.01, 0.03 and 0.05) nanoparticles were synthesized
by sol-gel auto combustion method.

Results:

XRD patterns confirmed the Sm3+ ion substitution through the undisturbed
wurtzite structure of ZnO. The crystallite size was decreased from 24.33
to 18.46 nm with Sm3+ doping. The hexagonal and spherical morphology of nanoparticles
was confirmed by TEM analysis. UV-visible studies showed that Sm3+
ion doping improved the visible light absorption capacity of Sm3+ iondoped ZnO
nanoparticles. PL spectra of Sm3+ ion-doped ZnO nanoparticles showed an
orange-red emission peak corresponding to 4G5/2→6HJ (J=7/2, 9/2 and 11/2) transition
of Sm3+ ion. Sm3+ ion-induced PL was proposed with a substantial increase
in PL intensity with a blue shift in peak upon Sm3+ content increase.

Conclusion:

Absorption peaks associated with doped ZnO nanoparticles were
moved to a longer wavelength side compared to ZnO, with bandgap declines
when Sm3+ ions concentration was increased. PL studies concluded that ZnO
emission properties could be tuned in the red region along with the existence of
blue peaks upon Sm3+ ion doping, which also results in enhancing the PL intensity.
These latest properties related to Sm3+ ion-doped nanoparticles prepared by a
cost-efficient process appear to be interesting in the field of optoelectronic applications,
which makes them a prominent candidate in the form of red light-emitting
diodes.
The Orwellian Reality of Counter-Terrorism Measures Under The ECHR
Authors: Thyroff-Kohl Sam
Published: October 2020

This paper seeks to analyze the impact of terrorism on the enjoyment of civil liberties guaranteed under the European Convention on Human Rights (ECHR). The paper profoundly assesses case law from the European Court of Human Rights (ECtHR) in order to assess how the Court manages to guarantee that rights are still respected and upheld, even when weighed against the most severe circumstances, namely terrorism. In doing so, the counter-terrorism legal system of one of the most controversial parties to the ECHR, the United Kingdom, is assessed to identify issues which arise when combating terrorism. Surveillance and stop-and-search are archetypical anti-terrorism measures that are limited through the ECtHR in order to not excessively infringe upon human rights, in accordance with Lloyd’s notion of imposing sufficient safeguards if new measures are enacted. Although the ECtHR can be considered an essential guarantor for human rights through its judicial dialogues and influences on domestic courts and governments, the issue of refoulment in torture cases must be readdressed in upcoming case-law. Moreover, grave privacy infringements are permitted to a terrifying extent, and the longer the ECtHR takes to take a solid stance against States abusing the aim of national security, the more severe it will naturally become, due to society’s incremental progression towards a digital life. Ultimately, terrorism tests democratic governments in a unique way, as imposing draconian measures would be an easy way to ensure safety. Nonetheless, fighting with one hand behind one’s back is necessary to uphold the status of a rights-respecting democracy. Only time will tell whether the ECtHR will evolve to give proactive verdicts to ensure human rights prior to their breach.
Pengaruh Jenis Oli Bekas Sebagai Bahan Bakar Kompor Pengecoran Logam Terhadap Waktu Konsumsi dan Suhu Maksimal pada Pembakaran
Authors: Hidayat Alif Rivan , Basyirun Basyirun
Published: October 2020

This study aims to determine the influence of distance traveled of used oil on fuel consumption rate and its maximum combustion temperature. In terms of consumption rate, used oil combustion tends to be slow because it must reach a certain point in order to burn. The maximum combustion temperature of used oil is comparable to other ordinary fuels, and it is suitable for use in metal casting. The study concluded that the longer the distance traveled, the faster the fuel consumption rate required. Used oil of 2200 km distance traveled is the fastest to burn, 0.8 liters in 745 seconds. The slowest to burn is the one with a distance traveled of 1800 km, which burns in 1031 seconds. The farther the distance traveled yields in a lower combustion temperature reached. At a distance traveled of 1800 km, the maximum temperature is 963.3 °C, while at 2200 km, the maximum temperature is 797.5 °C.Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh jenis oli bekas terhadap waktu konsumsi bahan bakar dan suhu maksimal pada pembakaran oli bekas. Ditinjau dari segi kecepatan konsumsi bahan bakar, pembakaran oli bekas konsumsinya cenderung lambat karena oli bekas harus mencapai titik tertentu agar dapat terbakar. Ditinjau dari suhu maksimal yang dihasilkan mampu bersaing dengan kompor – kompor dengan bahan lainya dan juga untuk ukuran kompor pengecoran logam sudah memadahi. Pada penelitian tersebut, dapat disimpulkan bahwa semakin jauh jarak tempuh maka semakin cepat/ rendah waktu konsumsi bahan bakar yang diperlukan. Jarak 2200 km merupakan waktu tercepat untuk menghabiskan 0,8 liter oli bekas dengan waktu 745 detik. Sementara waktu terlama yaitu 1031 detik pada jarak 1800 km. semakin jauh jarak tempuh maka suhu maksimal yang dihasilkan semakin rendah. Pada jarak 1800 km menghasilkan suhu maksimal mencapai 963,3 OC, sementara jarak 2200 km hanya mampu menhasilkan suhu maksimal sebesar 797,5  OC.
Pengaruh Tekanan Udara Terhadap Temperatur Pembakaran Oli Bekas pada Kompor
Authors: Ramadhan Gilang Wahyu , Basyirun Basyirun
Published: October 2020

Used oil is a waste, and optimization is needed to use it as a fuel properly.  In the combustion of used oil, air pressure is very influential in achieving optimal temperature. The air pressure affects the pressure of the incoming air. Other than temperature, air pressure affects and determines the inflow air density. The research uses an experimental method. This study concludes that air pressure affects the temperature of used oil combustion. The higher the air pressure, the more optimum the combustion temperature. A pressure of 2.5 bar yields in maximum temperature of 994.5 ℃ and a combustion time of 151 seconds. Conversely, air pressure of 0.5 bar yields in maximum temperature of 662.0 ℃ and longer combustion time, which is 843 seconds.Oli bekas merupakan limbah, dimana belum terlalu optimal untuk di jadikan bahan bakar. Pada pembakaran oli bekas tekanan udara sangat berpengaruh untuk mencapai temperatur yang optimal. Hal ini berpengaruh pada tekanan udara yang masuk.. Di mana tekanan udara merupakan salah satu faktor yang mempengaruhi dan menentukan kerapatan udara selain daripada suhu. Metode Penelitian yang berkaitan dengan pengaruh tekanan udara terhadap temperatur pembakaran oli bekas pada kompor gas ini menggunakan metode eksperimen. Penelitian ini dapat di simpulkan bahwa tekanan udara berpengaruh pada temperatur pembakaran oli bekas.  Pengaruh tekanan udara terhadap temperatur pembakaran yaitu apabila tekanan udara semakin tinggi maka temperatur pembakaran yang di hasilkan lebih maksimal dengan tekanan 2,5 bar mendapatkan 994,5 dan pembakaran semakin cepat yaitu mencatatkan waktu 151 detik, sebaliknya tekanan semakin rendah maka temperatur pembakaran minimal dengan 0,5 bar mendapatkan temperatur 662,0 dan memperoleh waktu pembakaran yang lebih lama yaitu sebesar 843 detik.
Democracia agonística: em busca de espaços participativos para o dissenso
Authors: Oliveira Wagner Vinicius de
Published: October 2020

esse artigo movimenta a questão da agonística no pensamento filosófico ocidental. Esse percurso investigativo tem como suporte as reflexões sobre o agon, no pensamento clássico ateniense, a praxis de guerra, na filosofia nietzschiana e, a proposta de democracia agonística, na filosofia política de Mouffe (2006). Distante da pretensão de realizar um inventário exaustivo sobre o tema, propõe-se analisar suas repercussões para compreender o espaço do dissenso nas chamadas democracias modernas ocidentais. Para tanto, defende-se o ponto de vista da inaptidão do modelo liberal para determinar o sentido e o alcance do substantivo abstrato democracia. Diante da opção de privilegiar o enfoque teórico, o instrumental metodológico será composto pela análise bibliográfica em livros especializados, artigos científicos, dissertação e tese referentes ao tema. Os resultados obtidos pela contraposição do procedimentalismo habermasiano com a democracia agonística, apontam para um fenômeno identificado por Rancière (2005) como “individualismo democrático”. Por fim, confirma-se a hipótese inicialmente apresentada estabelecendo duas conclusões: a necessidade do dissenso e a insuficiência das respostas liberais para servirem de único modelo para a democracia.
Application of Eugene Nida’s theory of translation to the English translation of surah Ash-Shams
Authors: JABAK OMAR Osman
Published: October 2020

The present study aimed to test the applicability of Nida’s theory of translation to an English translation of surah Ash-Shams of the Holy Qur’an. Towards that general aim, the study provided an overview of Nida’s theory of translation and the aspects whose applicability to the English translation of surah Ash-Shams would be tested. In addition, the study examined the Editor’s Preface to the English translation of the Holy Qur’an from which surah Ash-Shams was selected. A contrastive analysis was also devised and provided to help match the source text with the target text and measure the applicability of Nida’s theory of translation to both texts. The study revealed that, in general, Nida’s theory was applicable with the exception of one aspect related to word order. It is, therefore, recommended that large-scale research be conducted on the applicability of Nida’s theory to an English translation of the whole Holy Qur’an to either confirm the findings of this study or challenge them.
Translation, Rewriting and Creation: Interview of Professor Noël Dutrait, Translator of Gao Xingjian’s Lingshan (La Montagne de l’âme)
Authors: Wang Mingxing
Published: October 2020

This article is an interview with the leading French translator, Prof. Noel Dutrait, about his translation of translation of modern Chinese literature in France
Translation as Creation: Interview with Gao Xingjian
Authors: Wang Mingxing
Published: October 2020

This article is an interview with Gao Xingjian, the Nobel Prize laureate of 2000.
JE SUIS EN TRANSIT (Adventures in Google Translate)
Authors: Siemens Elena
Published: October 2020

An Experiment with Google Translate
PENGARUH KEPEMIMPINAN, KOMUNIKASI, DAN SISTEM RELIGI TERHADAP KETERLIBATAN MASYARAKAT DI DESA WISATA PANGLIPURAN
Authors: Trisna Semara I Made , Saputra I Putu David Adi
Published: October 2020

Pembangunan pariwisata berkelanjutan merupakan komitmen internasional untuk menjamin keberlanjutan pariwisata.  Bali, sebagai destinasi pariwisata utama di Indonesia, mengalami pertumbuhan pembangunan yang signifikan dalam 20 tahun terakhir. Pertumbuhan pembangunan tersebut secara langsung menyebabkan berkembangnya Desa Wisata di Bali. Hal tidak lepas dikarenakan adanya keterlibatan masyarakat. Salah satu Desa Wisata yang mengalami pertumbuhan dan perkembangan yang sangat signifikan adalah Desa Wisata Panglipuran. Riset ini disusun dengan tujuan untuk mengidentifikasi dan menganalisis pengaruh Kepemimpinan, Komunikasi, dan Religi terhadap Keterlibatan Masyarakat dalam pengembangan Desa Wisata Panglipuran. Teknik pengumpulan data menggunakan kuesioner tertutup dengan skala pengukuran menggunakan skala likert. Responden yang digunakan adalah masyarakat Desa Panglipuran sebanyak 100 orang. Teknik analisis data menggunakan software SmartPLS. Hasil penelitian yang diperoleh dari tabel Path Coefficients menunjukan nilai-nilai X1 à Y sebesar 2.858, X2 à Y sebesar 7.357, dan X3 à Y sebesar 1.883, yang berarti Kepemimpinan, Komunikasi dan Religi secara parsial berpengaruh positif dan signifikan terhadap keterlibatan masyarakat dam pengembangan Desa Wisata Panglipuran.
METODOLOGIA TITULOMÉTRICA PARA DETERMINAÇÃO DO TEOR DE BIODIESEL EM SOLUÇÕES COM DIESEL DE PETRÓLEO
Authors: Cancela Bruno R. , Cescon Leonardo S.
Published: October 2020

O Biodiesel é um dos principais combustíveis alternativos, produzido a partir de óleos vegetais e animais. A lei 13.033 de 2014 dispõe sobre a adição obrigatória do biodiesel no óleo diesel comercial, fixando um valor mínimo de 12 % em 2020. A maior causa de não conformidade no óleo diesel é o teor de biodiesel, sendo necessária uma fiscalização intensiva a fim de evitar tal problema. Para isso, existem convênios entre instituições de pesquisa e a ANP (órgão regulamentador), aumentando o número de fiscalizações e coibindo as fraudes. Para a determinação do teor de biodiesel a ANP utiliza a técnica de análise em infravermelho médio (FTIR) que exige muitas amostras e uma calibração complexa, difícil de ser executada por todas as instituições de pesquisas. A metodologia titulométrica apresentada neste trabalho é de fácil execução, pois faz uso apenas de métodos clássicos, não necessita de amostras de referência assim como grandes quantidades de amostras. Foi sintetizado biodiesel a partir de óleo de soja, milho e sebo bovino, misturando-os com óleo diesel puro em concentrações conhecidas, analisando o índice de saponificação de cada um deles em comparação com o teor de biodiesel. Tal metodologia apresentou bons resultados na determinação do teor de biodiesel. Foi realizada uma comparação entre ambas as metodologias, onde além de ser de execução mais simples, a metodologia titulométrica mostrou ser factível a criação de um modelo teórico de comparação entre o índice de saponificação da amostra e seu teor de biodiesel, o que pode contribuir para que mais laboratórios estejam aptos a executar o procedimento de análise e assim aumentando a eficiência da fiscalização.
Realidade Virtual em 360º e Inovação: Potencialidades e ausências nos portais Correio 24 horas e NE10
Authors: Melo Rostand de Albuquerque , Menezes Antônio Simões
Published: October 2020

O artigo investiga o uso de narrativas de realidade virtual em 360º para conteúdos jornalísticos com foco no contexto nordestino. O objetivo é identificar se há ou não experiências relevantes de jornalismo imersivo na mídia regional. Para tanto, discutimos conceitualmente a ideia de inovação no jornalismo e as características da realidade virtual e da estética das imagens em 360º. A coleta de dados foi realizada entre 2019 e 2020 com a aplicação de questionários on-line e mapeamento nos portais da região. Apresentamos os dados referentes aos casos específicos dos portais Correio 24 horas e NE10. O levantamento identificou a resistência do Correio 24h em experimentar a linguagem, enquanto no NE10 a tentativa de aplicação de vídeos em 360° foi interrompida antes que fosse possível constituir um formato para a cobertura factual.
A encenação midiática da política no filme "O Processo"
Authors: Zanetti Negrini Márcio , Freitas Gutfreind Cristiane , Antonine Stigger Helena Maria
Published: October 2020

Analisamos como o filme O processo (2018), dirigido por Maria Augusta Ramos, cria um ponto de vista sobre o impeachment de Dilma Rousseff. Para isso, realizamos a desconstrução da montagem, pontuando três particularidades: a deflagração do impeachment; a defesa político-jurídica; a disputa entre grupos conservadores e progressistas. Tais aspectos são atravessados por um traço em comum: as correlações entre as imagens de diferentes mídias e as imagens do filme, produzindo no documentário a visualidade da imagem dentro da imagem. Assim, enquanto documento de uma época, o longa-metragem revela o transcurso do golpe parlamentar como a encenação midiática da política.
Narrativa e animação: representações da maternidade na websérie “Conception”
Authors: Musse Christina Ferraz , Gonçalves Isabella de Sousa
Published: October 2020

Depois do New Journalism, houve uma nova aproximação entre jornalismo e narrativa, a partir de profissionais, que procuraram se utilizar de técnicas literárias para a produção de suas reportagens. A influência de tal movimento pode ser vista até hoje, em produtos que procuram se afastar do formato tradicional. Este é o caso da websérie “Conception”, produzida pelo New York Times, que traz a história sobre a maternidade de seis mulheres, por meio de animações curtas. Este artigo procura entender como a maternidade é representada na primeira temporada da websérie, a partir da análise de conteúdo, de Bardin (2011). Evidenciou-se que são abordadas temáticas diversificadas, a partir dos testemunhos, com a perspectiva das próprias personagens, amplificadas pelo uso de recursos multimídia, uma narrativa híbrida, ou jornalismo de animação.