bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Different Sedatives for Colonoscopy
Authors: Seleem Waseem M. , El Hossieny Khadeja M. , Abd-Elsalam Sherief
Published: August 2019

Background & Aims:

Sedation and analgesia are important elements of endoscopic
examinations; sedation for colonoscopy aims to relieve patient discomfort and anxiety, improve the
outcome of the examination, diminish the patient’s memory of the event and achieve comfortable
and technically successful endoscopic procedure.

Methods:

Our prospective study was carried out on 150 patients who were referred for colonoscopy;
they were divided into two groups based on the pre-endoscopic sedation given for them: propofol
fentanyl or propofol ketamine. Detailed histories, thorough physical examinations, and routine
laboratory investigations were performed for all patients, along with monitoring of their vital signs and
oxygen saturation levels (before, during and after colonoscopy), to assess safety, efficacy, recovery
times, complications of the sedative drugs, comfort of the patients and endoscopists.

Results:

There was no statistically significant difference between the two groups in terms of age,
sex and Body Mass Indexes (BMI). With respect to their Mean Arterial Blood Pressures (MAPs)
and heart rates, there was high hemodynamic stability in the propofol ketamine group, and both the
groups were efficacious, although the propofol fentanyl group had shorter recovery times than the
propofol ketamine group (3±1.7 minutes and 4±2.8 minutes, respectively). However, nausea, vomiting
and hypoxia were common in the propofol fentanyl group, while hallucinations were common
in the propofol ketamine group. In propofol fentanyl group; there was a significant decrease in the
heart rate more common in females (with age range 39-58 years) during and after colonoscopy
[p value 0.01].

Conclusion:

Sedation with propofol ketamine during colonoscopy was found to be safe and
efficacious to achieve hemodynamic stability with fewer complications than propofol fentanyl.
Safety Profiles and Pharmacovigilance Considerations for Recently Patented Anticancer Drugs: Lung Cancer
Authors: Bearz Alessandra , Cecco Sara , Francescon Sara , Re Francesco Lo , Corona Giuseppe , Baldo Paolo
Published: August 2019

Background:

Lung cancer is the most frequent cause of cancer-related death. In the last decades, the introduction of targeted therapies and more recently, of immunotherapy, has led to significant improvements in different outcomes of this malignant neoplasm.

Objective:

The present review provides a balanced overview of most recent targeted therapies and immunotherapies patented for the treatment of lung cancer.

Methods:

An extensive scientific literature and patent databases search were performed to identify peerreviewed studies containing information on recently patented drugs for the treatment of lung cancer, with a particular focus on their safety data and recently patented combinations.

Results:

The development of therapies directed to different pathways involved in the tumor angiogenesis, proliferation, and metastasis has transformed the clinical practice of lung malignancies. Several clinical trials have shown an improvement in terms of progression-free survival and overall survival in patients with advanced/metastatic lung cancer. Safety data, extracted from clinical trials and from the WHO global database of adverse drug reactions (VigiAccessTM database), show that recently patented drugs for the treatment of lung cancer are well-tolerated and most of the adverse events reported are mild to moderate.

Conclusion:

Currently, a consistent number of new drugs and combinations have been introduced for the treatment of patients with advanced-stage lung cancer. Safety data remain essential to better assess the long-term risk/benefit ratio of these valuable emerging therapies. The new patents’ development could provide further significant improvements for lung cancer treatment.
Spontaneous Recurrent Seizures Mediated Cardiac Dysfunction via mTOR Pathway Upregulation: A Putative Target for SUDEP Management
Authors: Sharma Supriya , Mazumder Arindam G. , Rana Anil K. , Patial Vikram , Singh Damanpreet
Published: August 2019

Background:

Alteration in electrophysiology, leading to cardiac dysfunction and subsequently a nontraumatic death is a complication of epilepsy known as “SUDEP” (Sudden Unexpected Death in Epilepsy).

Aims:

The present study was designed to understand the molecular changes and cardiac parameters during different phases of epileptogenesis in lithium-pilocarpine (Li-pilo) rat model of epilepsy.

Methods:

The animals were exposed to Li-pilo to induce Spontaneous Recurrent Seizures (SRS). Noninvasive blood pressure and electrocardiography was recorded at 7th, 28th and 75th day following pilocarpine administration, considered as latent, initial and late SRS phases, respectively. The serum biochemistry, cardiac histopathology, protein and mRNA expressions were studied, following electrocardiography on day 75.

Results:

The mean arterial pressure decreased during the latent phase, thereafter it progressively increased during the initial and the late SRS phases, as compared to the basal and the latent phase. Histopathological analysis of the heart sections indicated hypertrophy, degenerative changes and fibrous tissue deposition in epileptic animals, along with increased levels of lactate dehydrogenase and creatine kinase-MB in the serum. The expression of HIF-1α, phospho-S6, phospho-mTOR, TGF-β, collagen I and Na+/K+-ATPase α1 proteins, and mRNA levels of HIF-1α, mTOR, Rps6, Scn1b, Scn3b, Nav1.5 and TGF-β were increased in the cardiac tissue of epileptic animals, as compared to control.

Conclusion:

Our results conclusively showed that Li-pilo-induced SRS leads to cardiac dysfunction via mTOR pathway upregulation, thus suggested the regulatory control of mTOR pathway as a potential target for SUDEP management.
A Novel Approach of Drug Localization through Development of Polymeric Micellar System Containing Azelastine HCl for Ocular Delivery
Authors: Devi Sheetal , Saini Vipin , Kumar Manish , Bhatt Shailendra , Gupta Sumeet , Deep Aman
Published: August 2019

Background:

Development of polymeric micelles for the management of allergic
conjunctivitis to overcome the limitations of topical installation, such as poor patient
compliance, poor stromal permeability, and significant adverse effects, increase precorneal
residence time and efficacy, and also control the release of drug at the target site.

Objective:

The investigation was aimed at developing a polymeric micellar system of
Azelastine HCl for Ocular Delivery.

Methods:

Drug loaded micelles of tri-block copolymers Pf 127 were prepared by Thin
Film hydration method. The polymeric micelles formulations (F1 to F9) were assessed for
entrapment efficiency, micelle size, in vitro permeation, ex vivo transcorneal permeation,
in vivo Ocular Irritation, and Histology.

Results:

Optimized micelles formulation (F3), with the lowest micelle size of 92 nm, least
polydispersity value of 0.135, highest entrapment efficiency of 95.30 ± 0.17%, and a cumulative
drug permeation of 84.12 ± 1.26% in 8h, was selected to develop pH-sensitive
micelles loaded carbopol in situ gel. The optimized in situ gel (G4) proved to be superior
in its ex vivo transcorneal permeation when compared with Market Preparation and pure
drug suspension, exhibiting 43.35 ± 1.48% Permeation with zero-order kinetics (r2 =
0.9944) across goat cornea. Transmission Electron microscopy revealed spherical polymeric
micelles trapped in the gel matrix. A series of experiments showed hydration capability,
non-irritancy, and histologically safe gel formulation that had appropriate handling characteristics.

Conclusion:

A controlled release pH-sensitive ocular formulation capable of carrying the
drug to the anterior section of the eye via topical delivery was successfully developed for
the treatment of allergic conjunctivitis.
BlockChain Based Combinatorial Grouping Auction with Reserve Price Mechanism in Cloud Computing
Authors: Periyasami Karthikeyan , Venugopal Jeyakrishnan , Thirumoorthy Gopalakrishnan , Ramasamy RajaGopal , Balakrishnan Nagaraj
Published: August 2019

Background:

The block-chain is a growing decentralized scheme applied in many applications,
such as an auction, smart contract, Health, and banking sector. The cloud service providers
can sell the resource to cloud consumers using an auction. The main challenge in resource allocation
using auction is to provide reliability to the users.

Methods:

In this paper, a blockchain-based combinatorial grouping auction with a reserve price
mechanism (BCGAWRP) was proposed. The proposed scheme maximizes the total revenue and resource
utilization by assuring reliability. The proposed BCGAWRP performance was assessed by
simulating the cloud environment.

Results:

The experimental result shows that the proposed BCGAWRP algorithm increases revenue
more than the traditional combinatorial auction algorithm.

Conclusion:

Moreover, simulation studies show that reserve price is useful and provides a mechanism
to achieve the trade-off between the seller's and the buyer’s virtual machines.
Auditory Displays to Facilitate Object Targeting in 3D Space
Authors: May Keenan R. , Sobel Briana , Wilson Jeff , Walker Bruce N.
Published: August 2019

In both extreme and everyday situations, humans need to find nearby objects that cannot be located visually. In such situations, auditory display technology could be used to display information supporting object targeting. Unfortunately, spatial audio inadequately conveys sound source elevation, which is crucial for locating objects in 3D space. To address this, three auditory display concepts were developed and evaluated in the context of finding objects within a virtual room, in either low or no visibility conditions: (1) a one-time height-denoting “area cue,” (2) ongoing “proximity feedback,” or (3) both. All three led to improvements in performance and subjective workload compared to no sound. Displays (2) and (3) led to the largest improvements. This pattern was smaller, but still present, when visibility was low, compared to no visibility. These results indicate that persons who need to locate nearby objects in limited visibility conditions could benefit from the types of auditory displays considered here.
Breathing Space: Biofeedback Sonification for Meditation in Autonomous Vehicles
Authors: Morimoto Yota , van Geer Beer
Published: August 2019

The collective, calmspaces, sets out to create spaces for relaxation and contemplation through traditional architectural approach combined with modern digital technology. The ongoing project of the collective, breathing space (ademruimte in Dutch), uses unobtrusive sensing technology to monitor one’s breathing, and through designed light and sonic guides, the project tries to enhance the breathing exercise beneficial to regulating one’s emotion. The paper illustrates the project and its relevance to and potential for in-vehicle development. We then discuss the details of our implementations, along with video documentations of the early prototype, and a recently completed installation work.
Soccer Sonification: Enhancing Viewer Experience
Authors: Savery Richard , Ayyagari Madhukesh , May Keenan R. , Walker Bruce N.
Published: August 2019

We present multiple approaches to soccer soniﬁcation, focusing on enhancing the experience for a general audience. For this work, we developed our own soccer data set through computer vision analysis of footage from a tactical overhead camera. This data set included X, Y, coordinates for the ball and players throughout, as well as passes, steals and goals. After a divergent creation process, we developed four main methods of sports soniﬁcation for entertainment. For the Tempo Variation and Pitch Variation methods, tempo or pitch is operationalized to demonstrate ball and player movement data. The Key Moments method features only pass, steal and goal data, while the Musical Moments method takes ex-isting music and attempts to align the track with important data points. Evaluation was done using a combination of qualitative focus groups and quantitative surveys, with 36 participants completing hour long sessions. Results indicated an overall preference for the Pitch Variation and Musical Moments methods, and revealed a robust trade-off between usability and enjoyability.
Eight Components of a Design Theory of Sonification
Authors: Nees Michael A.
Published: August 2019

Despite over 25 years of intensive work in the field, sonification research and practice continue to be hindered by a lack of theory. In part, sonification theory has languished, because the requirements of a theory of sonification have not been clearly articulated. As a design science, sonification deals with artifacts—artificially created sounds and the tools for creating the sounds. Design fields require theoretical approaches that are different from theory-building in natural sciences. Gregor and Jones [1] described eight general components of design theories: (1) purposes and scope; (2) constructs; (3) principles of form and function; (4) artifact mutability; (5) testable propositions; (6) justificatory knowledge; (7) principles of implementation; and (8) expository instantiations. In this position paper, I examine these components as they relate to the field of sonification and use these components to clarify requirements for a theory of sonification. The current status of theory in sonification is assessed as it relates to each component, and, where possible, recommendations are offered for practices that can advance theory and theoretically-motivated research and practice in the field of sonification.
Exploring Sonic Parameter Mapping for Network Data Structures
Authors: Hansen Brian , Baltaxe-Admony Leya Breanna , Kurniawan Sri , Forbes Angus G.
Published: August 2019

In this paper, we explore how sonic features can be used to represent network data structures that deﬁne relationships between elements. Representations of networks are pervasive in contemporary life (social networks, route planning, etc), and network analysis is an increasingly important aspect of data science (data mining, biological modeling, deep learning, etc). We present our initial findings on the ability of users to understand, decipher, and recreate sound representations to support primary network tasks, such as counting the number of elements in a network, identifying connections between nodes, determining the relative weight of connections between nodes, and recognizing which category an element belongs to. The results of an initial exploratory study (n=6) indicate that users are able to conceptualize mappings between sounds and visual network features, but that when asked to produce a visual representation of sounds users tend to generate outputs that closely resemble familiar musical notation. A more in-depth pilot study (n=26) more speciﬁcally examined which sonic parameters (melody, harmony, timbre, rhythm, dynamics) map most effectively to network features (node count, node classiﬁcation, connectivity, edge weight). Our results indicate that users can conceptualize relationships between sound features and network features, and can create or use mappings between the aural and visual domains.
Is Sonification Doomed to Fail?
Authors: Neuhoff John G.
Published: August 2019

Despite persistent research and design efforts over the last twenty years, widespread adoption of sonification to display complex data has largely failed to materialize, and many of the challenges to successful sonification identified in the past persist. Major impediments to the widespread adoption sonification include fundamental perceptual differences between vision and audition, large individual differences in auditory perception, musical biases of sonification researchers, and the interdisciplinary nature of sonification research and design. The historical and often indiscriminate mingling of art and science in sonification design may be a root cause of some of these challenges. Future sonification design efforts that explicitly strive to meet either artistic or scientific goals may lead to greater clarity and success in the field and more widespread adoption of useful sonification techniques.
Designing Auditory Color Space for Color Sonification Systems
Authors: Osinski Dominik , Bizon Patrycja , Midtfjord Helene , Wierzchon Michał , Hjelme Dag Roar
Published: August 2019

Designing of color sonification systems provides a possibility of contribution to various fields ranging from rehabilitation of visually impaired through color perception, multisensory art experience to consciousness studies. The design process itself requires understanding and integrating knowledge from many difficult and inherently different branches of science and the resulting sonification method will be highly dependent on the purpose of the system. We present work in progress on designing and experimental verification of color sonification method that will be implemented in Colorophone – a wearable assistive device for the visually impaired, which enables perception of the information about color through sound. Although our system shows promising results in color and object recognition, we would like to enhance the existing color sonification method by designing a framework for experimental verification of our color sonification algorithm. The goal of this paper is therefore to briefly describe our way of thinking in order to provide the basis for the discussion.
FABRICATION OF NANOFIBRES BY ELECTROSPINNING USING KERATIN FROM WASTE CHICKEN FEATHERS, PVA AND AgNPs
Authors: MADAPALLY VARUN DINESH , M. PANDIMADEVI
Published: August 2019

Objective: To prepare and characterise keratin from chicken feathers (CF), collected from the slaughter house, and to blend with poly vinly alcohol (PVA) and biosynthesised silver nanoparticles (AgNPs) and to convert into nanofibers by an elctrospinning process.

Methods: The extraction of keratin from chicken feathers was done by sodium m-bisulphite. The solution was subjected to ammonium sulphate precipitation to separate keratin. The nanoparticles was synthesised using tridax procumbens. The isolated keratin and PVA was mixed in the ration 0f 50:50 with 1 ml of biosynthesised nanoparticles was blended and made into nanofibres by electrospinning technique.

Results: The precipitated protein was analysed using FT-IR analysis confirming the presence of β-keratin in the sample isolated from chicken feathers and the concentration of keratin was estimated to be 1.85 g/ml. PVA solution with 4% w/v had the best film forming ability. The solution containing keratin, PVA and silver nanoparticles was prepared in various proportions. These solutions when subjected to electrospinning, fibrous network was observed in 50:50 (PVA: Keratin) ratio with 1 ml of synthesised silver nanoparticle solution. Hydrogen bonding between keratin and PVA indicated in the XRD analysis showed successful film forming of the nanofiber, the DSC analysis also showed similar results as the obtained peak was at 214 °C which is in between the characteristic heat degradation temperature of both the keratin and PVA. The thermogravimetric analysis (TGA) showed high thermal stability as the complete degradation of the nanofiber was observed at 420 °C. Incorporation of metal nanoparticles by herbal approach using tridax procumbens in the nanofibers provided the antimicrobial properties. The nanofibres obtained by electrospinning process appeared stable and continous for solutions containing no more than 50% wt of CF. The average diameter of the nanofibres increased as the CF content increased.

Conclusion: Keratin isolated from the waste chicken feathers impregnated with biosyntheised silver nanoparticles using tridax procumbens and PVA can be converted into nanofibers by electrospinning process. Thus, the biocomposite nano fibers are shown as a novel eco-friendly material that must be adequately applied in the development of green composites for the biomedical applications such as wound dressings.
ISOLATION OF CYTOTOXIC CONSTITUENT FROM BIOACTIVITY GUIDED FRACTION OF ALYSICARPUS MONILIFER L. (DC.)
Authors: KAKRANI PURVI HARISHKUMAR , KAKRANI HARISH , RAVAL MANAN
Published: August 2019

Objective: Alysicarpus monilifer (Family Papilionaceae) has been used in the Indigenous system of medicine in tumor removal. The present study was designed to isolate and identify the constituent responsible for cytotoxic (anti-tumor) effects of the plant Alysicarpus monilifer.

Methods: The plant was powdered and extracted to give a methanolic extract. Initially, Hexane, chloroform, ethyl acetate and methanolic fractions of the methanolic extract of the plant were subjected to cytotoxic screening using cell line based assay (MTT assay and NRU assay). The chloroform fraction showed significant cytotoxicity, so it was further subjected to column chromatography, to separate the cytotoxic phytoconstituent. The cell lines selected were breast cancer cells (MCF-7 and MDA-MB-468) and Liver cancer cells (HepG2 and HLE cell). Results were calculated as percentage growth inhibition with respect to untreated (control) cells versus treated cells.

Result: A triterpene, Betulinic acid, was isolated from the aerial parts of Alysicarpus monilifer. The cytotoxic activity of the identified compound against MCF-7, MDA-MB-231, HLE and HepG2 cells was also found to be highly significant with 90% growth inhibition.

Conclusion: The triterpene was identified to be betulinic acid, to which the cytotoxic activity can be attributed. It is a first report of isolation of betulinic acid from the Alysicarpus species.
Facilitators and barriers to successful recruitment into a large comparative effectiveness trial: a qualitative study
Authors: Behringer-Massera Stephanie , Browne Terysia , George Geny , Duran Sally , Cherrington Andrea , McKee M Diane , Group GRADE Research
Published: August 2019

Background:
Recruitment of participants into research studies, especially individuals from minority groups, is challenging; lack of diversity may lead to biased findings.
Aim:
To explore beliefs about research participation among individuals who were approached and eligible for the GRADE study.
Methods:
In-depth qualitative telephone interviews with randomized participants (n = 25) and eligible individuals who declined to enroll (n = 26).
Results:
Refusers and consenters differed in trust and perceptions of risk, benefits and burden of participation. Few participants understood how comparative effectiveness research differed from other types of trials; however, some features of comparative effectiveness research were perceived as lower risk.
Conclusion:
We identified facilitators and addressable barriers to participation in research studies.
THE ANALYSIS OF PGSD STUDENTSâ€™ MISCONCEPTION OF DIAGNOSTIC TEST RESULT IN WORK AND ENERGY MATERIAL
Authors: Wiyoko Tri
Published: August 2019

The purpose of this study is to find out the misconception of undergraduates students majoring in Elementary Education Program (PGSD) towards the material of Work and Energy through diagnostic test. The study was carried out at STKIP Muhammadiyah Muara Bungo with the subject of research as many as 28 odd-semester PGSD students in the 2018/2019 academic year. Data collection techniques by random sampling and data analysis techniques used in this study are descriptive analysis. The research instrument consisted of 12 multiple choice questions accompanied by predetermined reasons. The results of the diagnostic tests of PGSD students in the basic science concept subjects of work material and energy found a misconception of 23.47% consisting of several concepts namely (a) work concept by force in the direction of displacement of 15%, (b) work by force which forms an angle of displacement of 42.5%, (c) Graph of force with displacement of 10.7%, (d) Energy imebcility law of 42.8%, (e) Mechanical energy of 6.2%.
UMA ANÁLISE DO ENDIVIDAMENTO MUNICIPAL NO BRASIL
Authors: Costa Rodolfo Ferreira Ribeiro , Lucena Raphael Douglas de Freitas
Published: August 2019

Este estudo apresenta uma abordagem raramente discutida no âmbito das finanças públicas, expondo a ideia de que o processo de endividamento é composto por um fator permanente e outro transitório. Com isso, o objetivo émensurar a parte permanente e a parte transitória do endividamento dos municípios brasileiros nos anos de 1989 a 2012. Para isso, é utilizado um método que pode ser aplicado em séries não estacionárias e não lineares, chamado de decomposição em modos empíricos. Os resultados indicam que a composição do processo de endividamento dos municípios é, em grande parte, formada pelo fator transitório da dívida, em outras palavras, os governos municipais vêm expandindo suas dívidas de modo geral em seus respectivos ciclos orçamentários.
CREDIT SUPPLY SHOCKS AND ECONOMIC ACTIVITY IN BRAZIL
Authors: Costa Filho Adonias Evaristo da
Published: August 2019

This paper studies the role of credit supply shocks in Brazil, throughBayesian Vector Autoregressions (BVARs) with sign restrictions. It isfound that credit supply shocks, either standalone or associated withthe bank lending channel of monetary policy, lead to relatively mildeects on output growth. Despite the credit deepening observed inthe last decade, credit shocks were not prominent drivers of businesscycles in Brazil.
Turistlerin Gıda Güvenliği Bilgisinin Şikâyet Etme Davranışına Etkisi
Authors: Ayaz Nurettin , Sünbül Kübra
Published: August 2019

Bu araştırmada
restoran işletmelerinden yiyecek ve içecek hizmeti talep eden turistlerin
şikâyet etme davranışına gıda güvenliği bilgisinin etkisi araştırılmaktadır. Bu
çerçevede İzmir ilini ziyaret eden ve restoran işletmelerinden hizmet talep
eden 532 yerli turistten anket tekniği kapsamında veri toplanmıştır. Anket
verilerinin analizi kapsamında yerli turistlerin gıda güvenliği bilgileri için
çapraz kirlenme, kişisel hijyen, temizlik ve doğru pişirme/saklama olmak üzere
dört boyut tespit edilmiştir. Yerli turistlerin şikâyet etme davranışları için
ise şikâyet etme bilinci, şikâyet etme eğilimi, duygusal tepki, firmanın cevap
verebilirliği, davranışsal tepki ve şikâyet yöntemi olmak üzere altı boyut
belirlenmiştir. Araştırma sonucunda görülmüştür ki gıda güvenliği bilgisi ile
şikâyet etme davranışı arasındaki ilişkiye yönelik basit doğrusal regresyon
analizi kapsamında, gıda güvenliği bilgisinin şikâyet etme davranışını
etkilediği belirlenmiştir.
Plano Municipal de Educação de Sorocaba/SP
Authors: Almenara Gilsemara Vasques Rodrigues , Lima Paulo Gomes
Published: August 2019

O objetivo geral desta pesquisa consiste em analisar a atuação do Conselho Municipal de Educação de Sorocaba/SP durante o período de elaboração do Plano Municipal de Educação sob a gestão do partido da Social Democracia Brasileira - PSDB. Utilizou-se como metodologia o emprego de entrevistas com os conselheiros, observações e análise documental, atas do C.M.E.SO. Por fim, concluímos  que o Conselho Municipal de Educação de Sorocaba/SP contribuiu para a democratização da gestão pública do município, mesmo diante de enfrentamentos políticos que tomaram lugar nas etapas preparatórias do Plano Municipal de Educação. Os resultados indicam que, apesar do aspecto positivo da busca por participação, ainda existe um longo caminho a ser percorrido que substitua a forma atual de funcionamento, mais burocrática.
Planos municipais de educação em movimento: desafios nos estados
Authors: Raimann Ari , Oliveira Camila Alberto Vicente de , Raimann Elizabeth Gottschalg
Published: August 2019

O Grupo de Estudos e Pesquisas sobre o Conselho Municipal de Educação no Brasil, GEP-CMEBr desenvolve pesquisas, reflexões e análises sobre os Conselhos Municipais de Educação (CME) a partir de uma investigação nacional (2014-2017) que reuniu instituições e pesquisadores de quatro estados da federação (MG, MT, MS, GO) com financiamento do CNPq. Atualmente, decorrente das experiências interinstitucionais vivenciadas no interior dos grupos de pesquisas envolvidos, ao mesmo tempo em que estes davam continuidade às investigações sobre os Conselhos, o Grupo tem-se ocupado de desenvolver nova pesquisa interinstitucional com a temática: acompanhamento e análise da implementação e do controle social dos Planos Municipais de Educação: a atuação dos Conselhos Municipais de Educação no Brasil (2018-2022). Objetiva-se avaliar os procedimentos adotados pelo CME para realizar o acompanhamento e controle social da implementação dos Planos Municipais de Educação nas regiões onde os pesquisadores se encontram.
ON THE ISSUE OF THE METHODOLOGY OF O. O. POTEBNIA’S RESEARCHES
Authors: Glushchenko Volodymyr
Published: August 2019

The main goal of the presented article is the analysis of M. M. Sokolov’s methodological conclusions about O. O. Potebnia’s scientific legacy from the point of view of their objectivity and faithfulness, particularly, to what extent the true achievements and drawbacks of O. O. Potebnia’s historic and phonetic works have been rendered. The tasks of the research included the following: to explain the meaning of M. M. Sokolov’s statements concerning the interpretation of O. O. Potebnia’s views on the genetic ties between languages, the phonetic laws and analogy. There has been also made an attempt to assess M. M. Sokolov’s definitions from the point of view of modern methodology, linguistic historiography and comparative linguistics. In our opinion, the suggested by M. M. Sokolov critical review of O. O. Potebnia’s views on the genetic ties between the languages, the phonetic laws and analogy is one-sided and simplified. The findings of the research have proved that the interconnection between the East-Slavic and Old Slavonic languages was described in O. O. Potebnia’s works from the point of view of the comparative historic method. O. O. Potebnia studied the interconnected phonetic laws which in his interpretation were postulated as exact, true not only for separate sounds but also their features (the conception of the “qualitative consonant shifts”). The critical review of M. M. Sokolov ’s judgments was predetermined by the fact that the scholar treated O. O. Potebnia’s historic and phonetic legacy not from the point of view of historical linguistics but according to “the assimilation of the past”. The theses postulated by M. M. Sokolov didn’t reflect the views of other representatives of Moscow linguistic school. The perspective of the further research is seen in the more detailed study of O. O. Potebnia’s scientific legacy as well as views of other representatives of Kharkiv linguistic school in the context of the linguistics of XIX cent. — early XXІ cent.
Improving Student Nurses’ Clinical-Reasoning Skills: Implementation of a Contextualised, Guided Learning Experience
Authors: Yauri Indriani , Nash Robyn , Ramsbotham Joanne
Published: August 2019

Well-developed clinical reasoning skills are central to the process of clinical judgement. However, the results of recent studies suggest that curricula and teaching approaches that support student nurses’ development of clinical reasoning skills have not yet been fully achieved. Cognitive apprenticeship offers a new approach to facilitate the development of complex thinking skills, for example, reasoning skills in making clinical decisions. This study examined the effect of an educational intervention utilizing principles of cognitive apprenticeship on students’ ability to apply clinical reasoning skills within the context of a purpose-built clinical vignette.A quasi-experimental, non-equivalent control-group design was used to evaluate the effect of the educational intervention on students’ accuracy, inaccuracy and self-confidence in clinical reasoning. Eighty-five undergraduate nursing students participated in the study. A purpose-built clinical vignette was utilised to collect data from study participants. Mixed-Design ANOVA with a significant level of p< 0.05 was employed. Both quantitative and qualitative data were collected. A statistically significant increase in students’ accuracy in clinical reasoning was found after the six-weeks educational intervention. Examination of the quantitative data at time 2 discovered a statistically significant higher accuracy in clinical reasoning score (p<0.00) of the intervention group as compared to the control group. Results from inaccuracy and self-confidence in clinical reasoning did not reach significance. Results from the qualitative data are reported separately. It is argued that interplay of small group discussion of domain specific case-scenarios and the provision of guided learning experience may play a role in achieving partially successful results.   This study makes an important contribution to nursing education by providing evidence to understand how best to facilitate nursing students’ development of clinical reasoning.
El Pastaza y el Upano, dos ríos tropicales que conectan los Andes a la Amazonía
Authors: Rostain Stéphen , De Saulieu Geoffroy
Published: August 2019

El Amazonas, llamado Marañón aguas arriba, nace en los Andes y se alimenta de los manantiales de la cordillera y los sedimentos arrancados a las laderas de la montaña. Los valles del Pastaza y del Upano son cabeceras de ríos que alimentan al Marañón. Solo 70 km de distancia los separan y drenan aguas no navegables al bajar de los Andes ecuatorianos. Pese a estas semejanzas, la comparación de los desarrollos sociales entre los dos valles muestra contrastes y puntos comunes que niegan los determinismos geográficos. Al mismo tiempo revelan el peso de las tendencias evolutivas regionales en el destino de las sociedades que los habitaban. Más allá de las notables diferencias geofísicas, los dos valles han tenido desarrollos precolombinos distintos aunque comparables. En efecto los períodos más antiguos, estuvieron claramente relacionados con los mundos amazónico y andino a la vez, mientras que los periodos más recientes, anteriores a la llegada de los europeos, marcan la formación de un universo cultural amazónico separado del mundo andino.
O rio Amazonas: fonte de diversidade
Authors: Goes Neves Eduardo
Published: August 2019

Este artigo traz uma breve apresentação da arqueologia da calha do rio Amazonas e de alguns de seus afluentes em sua porção brasileira. São apresentadas algumas das principais tradições tecnológicas características da região e é mostrado como a história antiga da Amazônia é caracterizada por uma grande diversidade cultural.
El valle del río Tocantins entre el fin del Pleistoceno y el Holoceno Medio: discutiendo hipótesis sobre poblamientos y fronteras
Authors: Bueno Lucas , Betarello Juliana , Lima Fernanda
Published: August 2019

Apresentamos neste texto uma síntese do contexto arqueológico para o vale do Rio Tocantins entre o fim do Pleistoceno e o Holoceno Médio. Através de um levantamento bibliográfico trabalhamos com uma mostra composta por 48 sítios arqueológicos para os quais dispomos de 137 datas no intervalo acima definido. A partir do cruzamento de dados sobre contexto ambiental (atual e pretérito), localização espacial, cronologia e composição artefatual desses sítios apresentamos hipóteses sobre a existência de processos diferenciados de povoamento entre médio e baixo vale, envolvendo transformação cultural e fronteiras culturais entre essas porções do vale do rio Tocantins.
Las poblaciones indígenas prehispánicas del río Paraná Inferior y Medio
Authors: Bonomo Mariano , Di Prado Violeta , Silva Carolina Belen , Scabuzzo Clara , Ramos van Raap Agustina , Castiñeira Carola , Colobig María de los Milagros , Politis Gustavo Gabriel
Published: August 2019

En este trabajo se sintetiza y discute el estado actual del conocimiento en la arqueología del río Paraná en Argentina, con especial énfasis en los estudios sistemáticos que nuestro equipo de investigación viene desarrollando desde hace más de 10 años en el Delta Superior, sudoeste de la provincia de Entre Ríos. Como resultado de las investigaciones se prospectó un amplio sector del área de estudio, se registraron más de 80 sitios arqueológicos, de los cuales se excavaron ocho. A través de la conformación de un grupo interdisciplinario, se aportó información relevante en temas tales como la cronología de las ocupaciones humanas, el uso de los recursos faunísticos y botánicos, las prácticas de producción y uso de la alfarería y la caracterización de las prácticas mortuorias. A partir de la información geoarqueológica y arqueobotánica se confirmó la génesis antrópica de las construcciones monticulares o cerritos y la presencia de horticultura de maíz, porotos y zapallo. También se evaluó la existencia de un bajo nivel de jerarquización social (ya mencionado en las primeras crónicas del siglo XVI) en las poblaciones asociadas con la entidad arqueológica Goya-Malabrigo, la que podría ser una derivación de la expansión meridional de los arawak. Finalmente, se abordó el estudio de la dispersión de los guaraníes y los modos de interacción con las poblaciones locales. En suma, los avances en las investigaciones de la última década muestran un panorama más complejo que integra la historia indígena local a procesos adaptativos generales ocurridos a lo largo de las Tierras Bajas sudamericanas.
Los ríos en la arqueología de Norpatagonia (Argentina)
Authors: Prates Luciano , Martínez Gustavo A. , Belardi Juan B.
Published: August 2019

El tema central de este trabajo es el uso humano de las tres principales cuencas fluviales en la Patagonia norte y centro-norte: el río Colorado, el río Negro y el río Chubut. Los objetivos del trabajo son sintetizar la información arqueológica disponible y evaluar la diversidad y los modos de explotación de los recursos, su rol en los sistemas de asentamiento y, complementariamente, en las prácticas inhumatorias y en los sistemas de comunicación. Una vez presentada la información arqueológica se definen las tendencias principales y se comparan con las observadas para sectores más meridionales de Patagonia. Se observa, por un lado, que en los sectores occidentales de las cuencas la cronología de los sitios es mayor, lo cual podría estar vinculado con las condiciones para la preservación y accesibilidad del registro arqueológico. Por otro lado, se destaca que la mayor densidad de sitios se encuentra en los sectores superiores e inferiores de las cuencas, lo cual podría vincularse con la productividad ambiental de las mesetas altas, en los sectores superiores, y de las planicies aluviales, en los sectores inferiores. Los tres casos muestran una alta densidad de inhumaciones, especialmente en los sectores inferiores.
Which quality of life scale should be used to evaluate acne vulgaris patients? CADI or DLQI? A prospective study
Authors: TATLIPARMAK Aslı , AKSOY Berna , KARADAĞ Ayşe Serap
Published: August 2019

Aim: Acne vulgaris is
one of the most common diseases that affects quality of life. While the Dermatology
Life Quality Index (DLQI) is the most frequently used life quality index for
dermatologic disorders, the Cardiff Acne Disability Index (CADI) is an
acne-spesific quality of life scale. The aim of this study was to determine
which scale should be more appropriate and practical to evaluate the quality of
life in acne patients and to compare the differences between two scales.Methods: Acne
scores of 273 patients who were admitted to the dermatology outpatient clinic
between December 2015 and November 2016 were determined by the Global Acne Grading
System (GAGS) (range 0 to 44). The DLQI (range 0 to 30) and CADI scores (range
0 to 20) were calculated to evaluate the effect of patients' quality of life.Results: The
mean GAGS score of the patients was 20.3, and the mean of CADI score was 6.1,
while the mean of DLQI was 6.0. There was a significant positive correlation
between total GAGS score and CADI and DLQI (r=0.639, p<0.001). When the
relationship between the distribution of acne lesions and quality of life
scales was evaluated; CADI score was significantly higher in the forehead
localization group than in the non-forehead localization group (p=0.012), and
the CADI and DLQI scores were higher in the upper back group than the group
without back localization (p=0.001and p= 0.017 respectively).

Conclusion: In our
study, it was observed that the DLQI and CADI scales were not superior to each
other in evaluating the quality of life in patients with acne. Besides, we
think that the effect of quality of life on facial acne cases can be determined
more clearly with CADI scale.
Analytic First-Order Derivatives of Partially Contracted N-Electron Valence State Second-Order Perturbation Theory (PC-NEVPT2)
Authors: Nishimoto Yoshio
Published: August 2019

A balanced treatment of dynamic and static electron correlation is important in computational chemistry, and multireference perturbation theory (MRPT) is able to do this at a reasonable computational cost. In this paper, analytic �first-order derivatives, speci�cally gradients and dipole moments, are developed for a particular MRPT method, state-specific partially contracted n-electron valence state second-order perturbation theory (PC-NEVPT2). Only one linear equation needs to be solved for the derivative calculation if the Z-vector method is employed, which facilitates the practical application of this approach. Comparison of the calculated results with experimental geometrical parameters of O3 indicates excellent agreement, although the calculated results for O3- are slightly outside the experimental error bars. The 0-0 transition energies of various methylpyrimidines and trans-polyacetylene are calculated by performing geometry optimizations and seminumerical second-order geometrical derivative calculations. In particular, the deviations of 0-0 transition energies of trans-polyacetylene from experimental values are consistently less than 0.1 eV with PC-NEVPT2, indicating the reliability of the method. These results demonstrate the importance of adding dynamic electron correlation on top of methods dominated by static electron correlation and of developing analytic derivatives for highly accurate methods.
Editorial
Authors: Guapindaia Mayra Calandrini
Published: August 2019

Editorial
A memória, o esquecimento e o compromisso do historiador
Authors: Barroncas Ramon
Published: August 2019

O artigo parte da discussão sobre o que é a memória, quais usos nós fazemos da memória e do passado e se tais usos podem se tornar abusivos. Qual o compromisso que o historiador deve adotar para utilizar a memória como fonte? Trabalhar com o passado demanda certa responsabilidade - ética e social - dos que se propõe a esse ofício. Entre a amnese e a anamnese, as identidades individuais e coletivas são formadas. Nesse sentido, as memórias definem padrões identitários de uma sociedade. Existe alguma diferença de conduta ética entre os que trabalham com memórias do tempo presente e os que trabalham com memória de um tempo remoto? O artigo discute essas questões levantando questionamentos que surgiram com acontecimentos como os regimes de exceção que ocorreram ao redor do mundo no séc. XX. No caso brasileiro, tais questões reaparecem no contexto de instauração da Comissão Nacional da Verdade, que se propõe a analisar os crimes perpetrados pelo Estado brasileiro durante o período que vai de 1946 até 1988.
A mídia ruandesa no genocídio de 1994
Authors: Da Fonseca Danilo Ferreira
Published: August 2019

O presente artigo busca entender como se deu a participação da mídia ruandesa no genocídio ruandês de 1994, refletindo o modo com que as diferenças tidas como étnica entre tutsis e hutus foram além de uma mera bipolarização étnica, incorporando no debate questões políticas, envolvendo principalmente a Frente Patriótica Ruandesa, e também questões históricas, como é o caso do papel dos Inkotanyis durante o período colonial.
Histórias de Mulheres Catadoras: rompendo silêncios, edificando resistências, construindo novas escritas históricas
Authors: Silva Luciana Codognoto , Menegat Alzira Salete
Published: August 2019

Nos últimos anos, importantes produções teóricas têm sido realizadas no campo das ciências humanas, de forma a voltar olhares às práticas corporais e às corporalidades, uma vez que ele, o corpo, tem assumido novos significados como forte agenciador dos processos de subjetivação feminina. Entretanto, é preciso advertir que nem sempre foi assim. Pouco enxergadas na História, as mulheres estiveram relegadas aos papéis binários de mãe, esposa e vida privada, sendo pouco percebidas em suas particularidades. Sendo assim, esta pesquisa objetiva demonstrar como a História tratou os corpos – biológico e social – e os gêneros, de maneira a enfatizar os traços que se sobressaíram em determinados períodos históricos, produzindo o refazer de metodologias de análises que abrem caminhos para estudar a história das mulheres, em especial daquelas pertencentes à Associação de Reciclagem de Presidente Epitácio – ARPE. Localizada no interior do Estado de São Paulo, a Associação conta com um número considerável de mulheres associadas e em cargos de liderança. Para tanto, será utilizada a metodologia em história oral em paralelo às contribuições teóricas elencadas pela história cultural e os estudos das relações de gêneros. Percebe-se que este espaço de atuação profissional tem possibilitado às mulheres catadoras novas formas de experiência histórica e social, a partir do momento em que elas buscam subverter a um dado padrão historicamente construído sobre a feminilidade. É, pois, no âmbito do trabalho com os recicláveis que as mulheres catadoras, apesar das adversidades vivenciadas cotidianamente, se percebem enquanto portadoras de histórias a serem publicizadas pelos registros historiográficos.
Ruth de Souza entre raça e gênero: reflexões sobre a trajetória de uma Dama negra, (1921-1954
Authors: Silva Julio Claudio da
Published: August 2019

Nos últimos anos o debate sobre a questão racial como variável significativa das relações sociais brasileira, ganhou expressivo espaço. Ao mesmo tempo em que a implementação da Lei 10.639/03, que estabelece o estudo da História e Cultura Afro Brasileira, demandou novos investimentos em pesquisas históricas, como estudos de cunho biográfico de personagens negros. Esse artigo toma como base a trajetória da atriz negra Ruth Pinto de Souza para refletir algumas questões relativas a presença da variável raça e gênero na sociedade brasileira.
A condição do pós-moderno frente à historiografia global
Authors: Alves Frederick Gomes
Published: August 2019

Trata-se de mapear o posicionamento do pensamento global relativamente ao pós-moderno. Argumenta-se que diante do processo de globalização a escrita da história necessita ser redimensionada a partir de uma reflexão sobre as condições atuais da experiência humana. Em primeiro lugar caracteriza-se a globalização como aquilo que confere a particularidade do presente histórico, sobretudo diante dos reordenamentos mundiais pós-1989, os pensadores globais argumentam que as transformações oriundas da globalização afetam as categorias do próprio pensamento, impossibilitando a manutenção de uma postura pós-moderna; em seguida, será esboçada a história do pensamento pós-moderno, que servirá para mostrar como o pensamento global desempenha o mesmo papel que aquele havia feito diante do pensamento moderno; por fim, expõe-se as críticas que o pensamento global coloca diante do pós-moderno, bem como as possibilidades de uma escrita da história no século XXI pautada pelo restabelecimento da história universal e de novas metanarrativas.
O espectro político liberal dos atores da Constituinte de 1823
Authors: Cordeiro Cecília Siqueira
Published: August 2019

O presente artigo procura balizar o comportamento político dos atores envolvidos na primeira experiência parlamentar brasileira, a Assembleia Constituinte de 1823. Para tanto, localizaram-se discursos parlamentares dentro do espectro político do liberalismo constitucionalista, ora identificados a uma vertente mais radical, ora mais conservadora, ou ainda a uma posição intermediária e conciliadora entre ambas. Dessa forma, percebe-se que os atores políticos do referido período histórico levaram a cabo um projeto nacional de modernização das instituições vigentes, sem, contudo, abandonar totalmente a tradição.Palavras-chave: Assembleia Constituinte de 1823; liberalismo; espectros políticos.