bluuebunny/crossref_metadata_2025 huggingface dataset:
Discurso fisioterapéutico, esguince a la subjetividad
Authors: Suárez-Reyes Carmen Elena , Robayo-Torres Aydeé Luisa
Published: February 2017

Introducción. Para el fisioterapeuta, incorporar la necesidad de identificar su discurso como un detonante para la trasformación de sujetos se hace esencial a partir de su función comunicativa, significativa y estética.Objetivo. Develar la subjetividad del fisioterapeuta colombiano que existe en su propio discurso en el ámbito clínico.Materiales y métodos. La búsqueda de un enfoque cualitativo hermenéutico se realizó en más de cincuenta textos, incluyendo libros, revistas, consultas en red y módulos de maestría con fuentes desde 1996. También se obtuvo información a partir de entrevistas con fisioterapeutas clínicos con más de diez años de experiencia en el campo clínico. El ejercicio de interpretación de dichos textos, en relación con los sujetos, se realizó en tres etapas: una descriptiva, otra hermenéutica y una de construcción teórica. Lo anterior permitió establecer tres métodos para la adquisición de la información: entrevistas, grabación de doble ciego y grupos de discusión. En este sentido, se analizaron los contenidos de los discursos del fisioterapeuta clínico, desde la oralidad y lo cinético, hallando regularidades en su contenido y proporcionando categorías características del ejercicio profesional.Conclusión. Se creó un espacio documental y reflexivo en el que se consignó el estado del arte del concepto de discurso en fisioterapia y su descripción e interpretación (lo decible y lo no decible) del fisioterapéutico clínico. Por lo tanto, los dos discursos se entendieron como fruto de verse, narrarse y juzgarse, teniendo en cuenta la incidencia que tienen en la constitución de la subjetividad del fisioterapeuta puesta en práctica en su desempeño profesional.
Diseño y validación de un instrumento de evaluación de condiciones de salud y trabajo de los fisioterapeutas en Colombia
Authors: Molina-Achury Nancy , Forero-Nieto Sandra , Ramos-Caballero Diana Marcela , Benavides-Piracón John , Quintana-Cortés Mónica Alejandra
Published: February 2017

Introducción. El estudio nacional de las condiciones de salud y trabajo de los fisioterapeutas no contaba con instrumentos diseñados y validados, coherentes con el marco analítico amplio de la relación entre salud y trabajo. Objetivo. Presentar los procesos de construcción y validación del instrumento denominado evaluación de condiciones de salud y trabajo de los fisioterapeutas en Colombia. Materiales y métodos. Se utilizó el coeficiente alfa de Cronbach para medir la relación entre las respuestas a cada variable con la magnitud de cada categoría, estableciendo mediciones fijas y consistentes con un elevado nivel de correlación. El proceso de validación se realizó en 1 711 fisioterapeutas de Colombia egresados desde el año 1980 hasta 2012. Resultados. La valoración de coherencia interna a través del alfa de Cronbach encontró cinco categorías del instrumento altamente coherentes, tres con valores mayores de 0.8: condiciones peligrosas del trabajo, organización de las tareas, satisfacción con el empleo, y dos con valoraciones superiores a 0.9: eventos en salud-enfermedad e identidad y autonomía. Discusión. El diseño y construcción del instrumento de valoración de las condiciones de salud y trabajo de los fisioterapeutas nacen de la necesidad del colectivo de fisioterapeutas para establecer líneas de base amplias sobre la relación entre el trabajo y la salud, y entender las condiciones de trabajo como elemento estructurante de la salud y enfermedad.
Adherencia a procesos de neurorrehabilitación funcional y su relación con la discapacidad y la calidad de vida en adultos colombianos con lesión medular
Authors: Henao-Lema Claudia Patricia , Pérez-Parra Julio Ernesto
Published: February 2017

Introducción. El conocimiento de la adherencia terapéutica en condiciones crónicas de salud como la lesión medular y su relación con la discapacidad y la calidad de vida puede reflejar mejores resultados en procesos de rehabilitación. Objetivo. Establecer el nivel de adherencia a procesos de neurorrehabilitación funcional y su relación con la discapacidad y la calidad de vida relacionada con la salud (CVRS) en adultos colombianos con lesión medular. Materiales y métodos. Estudio descriptivo correlacional con 330 participantes en el que se aplicaron diferentes instrumentos de medición: SMAN para adherencia a procesos de neurorrehabilitación funcional, SCI-DAS para discapacidad en lesiones medulares y WHOQOL-BREF para CVRS. Resultados. En el 80% la discapacidad global fue leve y moderada. 66% de los participantes reportaron niveles medio y alto de adherencia. El promedio de calidad de vida general fue de 68/100. Se encontró correlación significativa, por un lado, entre el componente ambiental de la discapacidad con la adherencia global y sus factores socio-económico, equipo de asistencia sanitaria, tratamiento y paciente y, por el otro, entre el dominio ambiental de la CVRS con la adherencia global y todos sus factores (p<0.001). Conclusión. Los principales determinantes de la adherencia a procesos de neurorrehabilitación funcional son los componentes ambientales de la discapacidad y la CVRS.
Epidemiology and antibiotic sensitivity of Staphylococcus aureus nasal carriage in children in Hungary
Authors: Laub Krisztina , Tóthpál Adrienn , Kardos Szilvia , Dobay Orsolya
Published: February 2017

The aim of this study was to assess the Staphylococcus aureus nasal carriage rate in healthy children all over Hungary and to specify some risk factors, the antibiotic resistance patterns of the bacteria, and their genetic relatedness. In total, 878 children (aged 3–6 years) were screened at 21 day-care centers in 16 different cities in Hungary, between February 2009 and December 2011. Samples taken from both nostrils were cultured on blood agar, and suspected S. aureus isolates were identified by β-hemolysis, catalase positivity, clump test, and nucA PCR. Methicillin-resistant strains were screened by mecA and mecC PCR. Antibiotic susceptibility was determined by agar dilution or gradient test strips. Pulsed-field gel electrophoresis was used for genotyping. S. aureus carriage rate was found to be 21.3%, which correlates well with international data. We found no statistically significant correlation between the gender or the sibling status and S. aureus carriage. All isolates were sensitive to oxacillin, trimethoprim–sulfamethoxazole, and mupirocin. The resistance rates for erythromycin, ciprofloxacin, clindamycin, gentamicin, and tetracycline were 7.5%, 0.5%, 1.1%, 3.7%, and 4.3%, respectively. The isolates showed very high genetic diversity. In summary, carried S. aureus isolates are more sensitive to antibiotics compared with clinical isolates in Hungary, and methicillin-resistant S. aureus carriage rate is very low yet.
Micro- and Nano-Fabrication of Polymer Based Microfluidic Platforms for BioMEMS Applications
Authors: Lai Siyi , Lee L. James , Yu Liyong , Koelling Kurt W. , Madou Marc J.
Published: February 2017

In this paper, we review the approaches developed in our laboratory for polymer-based micro/nanofabrication. For fabrication of microscale features, UV-LIGA (UV-lithography, electroplating, and molding) technology was applied for low-cost mass production. For fabrication of sub-micron or nanoscale features, a novel nano-manufacturing protocol is being developed. The protocol applies a novel nano-lithography imprinting process on an ultra-precision motion-control station. It is capable of economically producing well-defined pores or channels at the nanometer scale on thin polymer layers. The formed thin layers can be used as nano-filters for chemical or bio-separation. They can also be integrated into miniaturized devices for cell immunoprotection or tissue growth. For bonding of polymer-based microfluidic platforms, a novel resin-gas injection-assisted technique has been developed that achieves both bonding and surface modification. This new approach can easily seal microfluidic devices with micron and sub-micron sized channels without blocking the flow path. It can also be used to modify the channel shape, size, and surface characteristics (e.g., hydrophilicity, degree of protein adsorption). By applying the masking technique, local modification of the channel surface can be achieved through cascade resin-gas injection.
Fabrication of a Conductometric Sensor for Crevice Corrosion Studies
Authors: Wang Xiaoyan , Kelly Robert G. , Lee Jason S. , Reed Michael L.
Published: February 2017

Microfabricated crevice corrosion samples have been employed in experiments that provided important information necessary for developing an accurate, comprehensive, and reliable crevice corrosion model. Acquiring real-time spatial information of crevice corrosion is also essential in analyzing corrosion processes. Integration of arrays of solid-state microsensors, such as conductometric sensors, pH and other ion concentration potentiometric sensors, into the crevice corrosion samples will allow for in-situ real-time data acquisition. In the present work, crevice corrosion samples with conductometric sensor arrays are made using the techniques developed for thin film semiconductor processing and microelectromechanical systems (MEMS) fabrication. The crevice corrosion testing sample is constructed by coupling a crevice former to a crevice substrate and has a uniform crevice gap. A conductometric sensor array built on a silicon wafer is incorporated into the crevice former. Each of these sensors is composed of a pair of thin film gold electrodes, which enables in-situ spatial conductivity analysis of crevice corrosion. Information about metal ion concentration and active chemistry inside the crevice can also be obtained.
Electrical Properties and Noise of Poly SiGe Deposited at Temperatures Compatible With MEMS Integration on Top of Standard CMOS
Authors: Sedky Sherif
Published: February 2017

The rapid development of MicroElectroMechanical Systems (MEMS) implied monolithic integration of these devices with the driving, controlling and signal processing electronics on the same CMOS substrate as this can improve performance, yield and reliability as well as lower the manufacturing, packaging and instrumentation costs. The post-processing route (fabricating MEMS on top of CMOS) is preferred as it avoids introducing any changes in standard foundry CMOS processes. Depending on the specific metallization type and the design requirements, post-processing limits the maximum fabrication temperature of MEMS to 450°C or 520°C [1], as this avoids introducing any damage or degradation to interconnects. This temperature constraint is quite strict for post processing surface micromachined MEMS, as it might affect relevant physical properties of the active element of MEMS such as crystallization, growth rate, mechanical properties, dopant activation, electrical resistivity, etc.. Polycrystalline silicon germanium (poly SiGe) is an attractive material for such applications due to its low amorphous to polycrystalline transition temperature, which can be as low as 400°C (with the appropriate germanium content). Furthermore, the mechanical properties of poly SiGe proved to be suitable for surface micromachining application [2]. In addition it is compatible with standard IC fabrication process, and hence it enables monolithic integration of MEMS with the driving electronics.
Sputtered Tantalum as a Structural Material for Surface Micromachined RF Switches
Authors: Sedky Sherif , Fiorini Paolo , Witvrouw Ann , Baert Kris
Published: February 2017

Micro-electro-mechanical systems (MEMS) are batch fabricated miniature systems with both electrical and non-electrical (e.g. mechanical) functionalities. Examples of such MEMS are miniature mechanical switches, acceleration sensors, gyroscopes etc… RF-MEMS devices are an emerging class of MEMS devices used for RF signal processing in telecommunication applications. For example, metal surface micro-machined switches are a promising alternative for current solid state switches or mechanical reed relays due to their potential for miniaturization, integration and improved performance. RF-MEMS switches normally consist of a metal bridge or cantilever electrode, which can be pulled in towards a bottom electrode by electrostatic forces [1]. The bridge material is often chosen to be Al or an Al-alloy because of its low resistivity [2]. During each switch cycle the metal top electrode goes through a mechanical stress cycle. These successive stress cycles might lead to reliability problems such as fatigue and/or creep. This is certainly the case for Al, which is known to have a low creep resistance [3]. Several alternatives have been investigated as alloying Al with other materials [4], or replacing Al with metals having better mechanical properties, specifically low creep, such as Tungsten (W) or Tantalum (Ta). Especially high melting point materials are interesting alternatives as the creep resistance is expected to increase with the melting point [5]. If we consider surface micromachined RF switches, the pull in voltage and sheet resistance are two important parameters that should be taken into consideration while selecting the switch material. In general, the pull in voltage depends on mean stress, lateral dimensions, layer thickness and Young's modulus. In case of stress free films, a material having a low Young's modulus is preferred for low pull-in voltage. As W is known to have high intrinsic stress [6], and a higher Young's modulus compared to Ta [7], it is instructive to consider Ta as a structural material for surface micromachining applications.
Microfabricated Device for Impedance-Based Detection of Bacterial Metabolism
Authors: Gómez Rafael , Ladisch Michael R. , Bhunia Arun K. , Bashir Rashid
Published: February 2017

We present the use of a microfabricated device for impedance-based detection of a few live bacterial cells. Impedance-based detection relies on measuring changes in the AC impedance of two electrodes immersed in a liquid were the bacteria are cultured, caused by the release of ionic species by metabolizing bacterial cells. Rapid detection of a few cells (1 to 10) is possible if the cells are confined into a volume on the order of nanoliters. A microfluidic biochip prototype has been fabricated to test this miniaturized assay. The conductance of the bacterial suspensions is extracted from measuring their complex impedance in a 5.27 nl chamber in the biochip, at several frequencies between 100 Hz and 1 MHz. Measurements on suspensions of the bacteria Listeria innocua, Listeria monocytogenes, and Escherichia coli in a low conductivity buffer demonstrate that, under the current experimental conditions, the minimum detection level is between 50 and 200 live cells, after two hours of off-chip incubation. Work is in progress to develop techniques for selective capture of bacteria inside the chip, and to minimize background changes in impedance during on-chip incubation.
Modeling and Simulation of a High Frequency MEMS-Fabricated Ultrasonic Nozzle
Authors: Tsai S. C. , Tseng T.K. , Song Y. L. , Chou Y. F. , Tsai C. S. , Chang P.Z.
Published: February 2017

This paper reports on the design and simulation of micro-fabricated 0.5 MHz Si-based ultrasonic nozzles that consist of multiple sections of Fourier horns of half wavelength design. Such high frequency ultrasonic nozzles should produce 10-15μm-diameter uniform precursor drops for nanoparticle synthesis by means of spray pyrolysis at ambient pressure. Results of 3-D simulation using a commercial FEM program, ANSYS, show existence of one resonant frequency of pure longitudinal vibration, which is very close to the design value. The results also show that at this resonant frequency increase in vibration amplitude at the nozzle tip is very close to the theoretical values of 2n, where n is the number of horn section. Therefore, the required electric drive power should be drastically reduced and the transducer failure in ultrasonic atomization can be more readily avoided.
Wafer Level Micropackaging of MEMS Devices Using Thin Film Anodic Bonding
Authors: Rohwer Lauren E. S. , Oliver Andrew D. , Collins Melissa V.
Published: February 2017

A wafer level packaging technique that involves anodic bonding of Pyrex wafers to released surface micromachined wafers is demonstrated. Besides providing a hermetic seal, this technique allows full wafer release, provides protection during die separation, and offers the possibility of integration with optoelectronic devices. Anodic bonding was performed under applied voltages up to 1000 V, and temperatures ranging from 280 to 400°C under vacuum (10-4Torr). The quality of the bonded interfaces was evaluated using shear strength testing and leak testing. The shear strength of Pyrex-to-polysilicon and aluminum bonds was ∼10-15 MPa. The functionality of surface micromachined polysilicon devices was tested before and after anodic bonding. 100% of thermal actuators, 94% of torsional ratcheting actuators, and 70% of microengines functioned after bonding. The 70% yield was calculated from a test sample of 25 devices.
Solvothermal Pathways to Transition Metal Oxides
Authors: Michailovski Alexej , Patzke Greta R.
Published: February 2017

A straightforward solvothermal pathway towards anisotropic nanoscale molybdenum, vanadium and tungsten oxides has been established. They are formed quantitatively from one-step procedures within a few days or hours of autoclave treatment in the temperature range between 100 and 220 °C. The addition of straightforward ionic additives (e.g. alkali halides) leads to a versatile interplay between the formation of novel polymolybdates(VI) and the production of oxidic nanoparticles. Key solvothermal features (role of the precursor, solvothermal parameter window, influence of ionic additives) of the individual transition metal oxides are investigated with respect to the development of general synthetic guidelines and predictive concepts.
Structure, Morphology and Photocatalytic Activity of Novel Hydrothermal ZnBiVO4
Authors: Kale B. B. , Baeg Jin-Ook , Lee Sang Mi , Moon Sang-Jin , Chang Hyunju , Lee Chul Wee
Published: February 2017

We offer a synthesis of novel nanocrystalline ZnBiVO4 using hydrothermal method. The same novel catalyst was synthesized using solid-state route for the first time. We have exemplified the hydrothermal synthesis of this new compound using zinc nitrate, bismuth nitrate and ammonium metavanadate. The ZnBiVO4 was synthesized using zinc oxide, bismuth oxide and vanadium oxide by solid-state route. X-ray difractometry for its structural study and Scanning Electron Microscopy for the particle morphology characterized the resultant product. The prima facie observations revealed the formation of tetragonal crystallites of hydrothermal ZnBiVO4 ranging from 40-50nm. The BET surface area of hydrothermal ZnBiVO4 was increased 9 times as compared to solid state ZnBiVO4. The steepness of the UV-visible DRS Diffuse Reflectance Spectra) absorption edge, suggests the good crystalline nature of the material. From the photodecomposition of H2S, it is noteworthy that the hydrogen evolution was enhanced by 70% in hydrothermal ZnBiVO4.
Nanoscale Structural Features of Ultra-fine Zirconia Powders Obtained Via Precipitation-hydrothermal Treatment Route
Authors: Sadykov Vladislav A. , Zaikovskii Vladimir I. , Zyuzin Dmitrii A. , Moroz Ella M. , Burgina Elena B. , Ishchenko Arcady V. , Kostrovskii Vitaly G. , Matyshak Valerii A.
Published: February 2017

Genesis of the structure of zirconia fine particles prepared by precipitation of amorphous hydrated zirconia by ammonia from the ZrO(NO3)2 solution followed by a mild hydrothermal treatment (HTT) of precipitate, washing and calcination under air up to 1000 °C has been studied by HRTEM, X-ray diffraction, Raman and FTIRS. HTT rearranges the structure of amorphous zirconia, which helps to obtain nearly single-phase monoclinic nanozirconia (particle size 5-15 nm) after a mild calcination at 500 °C. Dehydroxilation and sintering of these nanoparticles at higher (600-650 °C) temperatures generate polysynthetic (001) twins. Modeling revealed that reappearance of the (111) “cubic” reflex in XRD patterns of samples calcined at 600-650 °C can be due to these extended defects. In their vicinity, the seven-fold Zr-O coordination sphere is retained, while packing of ZrO7 polyhedra is varied towards more symmetric structures, thus causing disappearance of the Raman spectra.
Hawk on a power Line
Authors: Wallace Robert
Published: February 2017

Robert Wallace:El halcón en el cable de energía eléctrica.Traducción: Miguel Zapata Ferreira.
Executive functions in partner violence: A Neurocriminological perspective/Funciones ejecutivas en la violencia de pareja: una perspectiva Neurocriminológica
Authors: Salas picon Wilson Miguel , Cáceres Duran Ibeth Rocío
Published: February 2017

Las neurociencias han permitido el establecimiento de nuevos caminos para la comprensión de las conductas que poseen un alcance jurídico, especialmente la violencia. Por lo anterior, el estudio evaluó el desempeño de las funciones ejecutivas en un grupo de hombres que poseen antecedentes por violencia de pareja. Para la recolección de datos, se utilizaron las siguientes pruebas: Rey- Copia, STROOP, Wisconsin, TMT y Laberintos de Porteus. Los resultados indicaron que el grupo de hombres maltratadores presentan un mejor desempeño; aspectos que facilitan la interacción de éstas personas con el medio social en que se desenvuelve y favorecen una interpretación adecuada a la realidad, permitiendo que generen respuestas adaptativas ante las situaciones que les generen malestar. Estos resultados contribuyen a nivel empírico al marco conceptual que desde la psicología jurídica se ha venido construyendo para su comprensión. Asimismo, reafirma la necesidad de realizar la intervención desde las necesidades del individuo.
Use of an Online Educational Module to Improve Physician Skills to Diagnose Vaginitis
Authors: Tong Iris , Epstein Rachel , Hardy Erica
Published: February 2017

This article was migrated. The article was not marked as recommended. Background: The availability of rapid laboratory diagnostic tests, coupled with physicians' lack of confidence in their microscopy skills, may cause physician educators to teach microscopy less in residency training when diagnosing vaginitis and cervicitis. Objective: We sought to evaluate the level of comfort of diagnosing vaginitis and cervicitis with microscopy and to determine whether an online educational module could improve diagnostic skills among our primary care residency clinic preceptors. Methods: We created an online education module, aimed at assessing diagnostic microscopy skills and at improving knowledge about vaginitis and cervicitis. Preceptors were invited to complete the education module and a pre- and post-module survey to assess their knowledge and practice patterns. Results: Of 33 eligible preceptors, 21 (63%) completed both pre- and post-surveys. Twenty preceptors (95%) found the teaching module helpful, and 76.2% reported desiring better training in microscopy. Preceptors' knowledge scores improved significantly post-intervention (p = 0.0045). Preceptors who were female, who trained in Medicine-Pediatrics, and whose patient panels were predominantly female had higher scores. Discussion: Our teaching module was well-received by preceptors, and preceptors' testing scores improved significantly post-intervention. Online education modules may be an effective method to improve physicians' office-based microscopy skills to diagnose vaginitis and cervicitis.
Personal Financial Literacy Among U.S. Medical Students
Authors: Jayakumar Kishore L. , Larkin D. Justin , Ginzberg Sara , Patel Mitesh
Published: February 2017

This article was migrated. The article was not marked as recommended. Background: Personal financial literacy is associated with successfully managing debt, investing for retirement, and coping with financial strain. Though medical students occupy a financially unique niche due to high debt, little is known about their financial literacy. In this study, the authors' objective was to assess financial literacy among medical students and to evaluate demographic, educational, and financial factors associated with financial literacy. Methods: In March to April 2015, the authors administered a cross-sectional survey to all first- (M1) and fourth-year (M4) medical students at seven geographically distributed U.S. medical schools. The survey measured performance on a financial literacy assessment, educational debt burden, and past retirement contributions. Results: The survey response rate was 37.5% (1052/2806). Students answered 47.4% of the financial literacy questions correctly. Factors associated with higher (above-the-median) financial literacy performance included male gender (Odds ratio [OR] = 2.19; 95% confidence interval [CI]: 1.70-2.83; P <0.01), joint MD/MBA degree (OR = 2.47, 95% CI: 1.24-4.90; P = 0.02), finance-related undergraduate major (OR = 5.79, 95% CI: 1.02-32.92; P = 0.05), self-assessed financial knowledge (OR = 1.79, 95% CI: 1.45-2.20; P <0.01), and confidence in personal financial management (OR = 1.19, 95% CI: 1.01-1.42; P = 0.05). Financial literacy among M4s who had received school-provided personal financial counseling or information was not significantly higher than those who had not received it (50.7% vs. 50.0%, P = 0.79). A 1 percentage point increase in financial literacy performance was associated with a 3% increase in the odds of contributing to a tax-advantaged retirement account (OR = 1.03, 95% CI: 1.02-1.05; P <0.01) and over a $600 decrease in debt (β = -$642, 95% CI: -$1123-$161; P <0.01). Discussion: Financial literacy among both first-year and fourth-year U.S. medical students was low. School-provided personal financial counseling or information for fourth-year students was not associated with improved financial literacy. Students with higher financial literacy incurred less debt and were more likely to invest for retirement.
Dental anomalies in an orthodontic patient population with maxillary lateral incisor agenesis
Authors: Citak Mehmet , Cakici Elif Bahar , Benkli Yasin Atakan , Cakici Fatih , Bektas Bircan , Buyuk Suleyman Kutalmış
Published: February 2017

ABSTRACT Introduction: The purpose of this study was to evaluate the prevalence of dental anomalies in a subpopulation of orthodontic patients with agenesis of maxillary lateral incisors (MLI). Methods: The material of the present study included the records of the 1964 orthodontic patients. Panoramic radiographs and dental casts were used to analyze other associated eight dental anomalies, including agenesis of other teeth, dens invaginatus, dens evaginatus, peg shaped MLI, taurodontism, pulp stone, root dilaceration and maxillary canine impaction. Results: Out of the 1964 patients examined, 90 were found to have agenesis of MLI, representing a prevalence of 4.6%. The most commonly found associated-anomalies were agenesis of other teeth (23.3%), peg-shaped MLIs (15.6%), taurodontism (42.2%), and dilacerated teeth (18.9%). Conclusion: Permanent tooth agenesis, taurodontism, peg-shaped maxillary lateral incisor, and root dilacerations are frequently associated with maxillary lateral incisor agenesis.
The Antiproliferative Role of Lanreotide in Controlling Growth of Neuroendocrine Tumors: A Systematic Review
Authors: Michael Michael , Garcia-Carbonero Rocio , Weber Matthias M. , Lombard-Bohas Catherine , Toumpanakis Christos , Hicks Rodney J.
Published: February 2017

Background

Neuroendocrine tumors (NETs) are a heterogeneous group of tumors, with >50% of cases involving the gastrointestinal system or pancreas. Somatostatin analogs (SSAs) are used for treating NET-related secretory syndromes and, more recently, for their antiproliferative effects. We conducted a systematic review of published literature on the antiproliferative efficacy and safety of the SSA lanreotide Autogel in the management of NETs to gain a fuller understanding of the evidence and identify future areas of research.

Methods

Searches were conducted in PubMed up to March 16, 2016, and in the proceedings of four congresses from 2013 to 2016.

Results

Screening of 1,132 publications identified in the searches found 40 relevant publications, including 27 full-length publications and 13 congress abstracts. Twenty-four of these publications reported antiproliferative efficacy data for lanreotide Autogel. The CLARINET study showed that 120 mg lanreotide Autogel every 4 weeks improves progression-free survival (PFS) in patients with gastroenteropancreatic (GEP)-NETs, with grade 1 or grade 2 (Ki-67 <10%) disease, providing class I evidence of its antiproliferative effects. The CLARINET open-label extension study reported a median PFS of 32.8 months with lanreotide Autogel. Other smaller studies generally support CLARINET.

Conclusion

Current clinical evidence shows that lanreotide Autogel has good antiproliferative activity with favorable safety and tolerability in patients with GEP-NETs, suggesting it should be considered as an early first-line treatment in this population. Further studies are needed to assess the potential benefits of higher doses and the use of lanreotide Autogel in combination therapy and as maintenance therapy in the absence of disease progression following other therapies.
Centrifuge modelling of the influence of slope height on the seismic performance of rooted slopes
Authors: Liang T. , Knappett J. A.
Published: February 2017

This paper presents an investigation into the influence of slope height on the role of vegetation to improve seismic slope stability. Dynamic centrifuge modelling was used to test six slope models with identical soil properties and model slope geometry within different centrifugal acceleration fields (10g and 30g, respectively) representing 1:10 and 1:30 scale slopes, that is, slopes of different height at prototype scale. A three-dimensional (3D) root cluster analogue representing a tap-root system, with root area ratio, root distribution and root length representative of a 1:10 and 1:30 scale tree root cluster (of rooting depth 1·5 m at prototype scale) was modelled using 3D printing techniques. A sequence of earthquake ground motions was applied to each model. The influences of filtering out low-frequency components of the earthquake motion, such as was necessitated at the lowest scaling factor owing to the practical limitations of the earthquake simulator, on dynamic amplification of motions within the slopes and the seismically induced slip, were first revealed. Subsequently, the effects of slope height on acceleration and deformation response of vegetated slopes were illustrated. It was found that the beneficial effects of roots on improving the seismic performance varied with the height of the slope. As an individual engineering technique for slope stabilisation, root reinforcement will not be such an effective solution for taller slopes, and complementary hard engineering methods (e.g. piles, retaining walls) will be necessary. For slopes of smaller heights (e.g. low-height embankments along transport infrastructure), however, vegetation appears to represent a highly effective method of reducing seismic slip.
Creep improvement factors for vibro-replacement design
Authors: Sexton Brian G. , Sivakumar Vinayagamoothy , McCabe Bryan A.
Published: February 2017

Although the vibro-replacement stone column technique is being deployed increasingly in soft cohesive soil deposits in which creep settlements may be significant/dominant, the majority of existing stone column settlement design methods are either non-specific or pertain to primary settlement only. Consequently, in the absence of further guidance, designers sometimes apply the same settlement improvement factor to creep settlements that they have estimated for primary settlements. In this paper, Plaxis 2D finite-element analyses carried out in conjunction with the elasto-viscoplastic soft soil creep model have indicated that settlement improvement factors are lower when creep is considered and therefore the design of stone columns ignoring creep is unconservative. These analyses were used to establish the impact of a range of relevant variables on ‘primary’, ‘total’ and ‘creep’ settlement improvement factors, leading to the development of a simplified empirical approach for predicting creep settlement improvement factors for use in conjunction with an existing primary settlement design method.
Pharmacologic Blockade of αvβ1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo
Authors: Chang Yongen , Lau Wei Ling , Jo Hyunil , Tsujino Kazuyuki , Gewin Leslie , Reed Nilgun Isik , Atakilit Amha , Nunes Ane Claudia Fernandes , DeGrado William F. , Sheppard Dean
Published: February 2017

Activated fibroblasts are deemed the main executors of organ fibrosis. However, regulation of the pathologic functions of these cells in vivo is poorly understood. PDGF receptor β (PDGFRβ) is highly expressed in activated pericytes, a main source of fibroblasts. Studies using a PDGFRβ promoter–driven Cre system to delete αv integrins in activated fibroblasts identified these integrins as core regulators of fibroblast activity across solid organs, including the kidneys. Here, we used the same PDGFRβ-Cre line to isolate and study renal fibroblasts ex vivo. We found that renal fibroblasts express three αv integrins, namely αvβ1, αvβ3, and αvβ5. Blockade of αvβ1 prevented direct binding of fibroblasts to the latency-associated peptide of TGF-β1 and prevented activation of the latent TGF-β complex. Continuous administration of a recently described potent small molecule inhibitor of αvβ1, compound 8, starting the day of unilateral ureteral obstruction operation, inhibited collagen deposition in the kidneys of mice 14 days later. Compound 8 also effectively attenuated renal failure, as measured by BUN levels in mice fed an adenine diet known to cause renal injury followed by fibrosis. Inhibition of αvβ1 integrin could thus hold promise as a therapeutic intervention in CKD characterized by renal fibrosis.
Trends in Discharge Claims for Acute Myocardial Infarction among Patients on Dialysis
Authors: Shroff Gautam R. , Li Shuling , Herzog Charles A.
Published: February 2017

Analysis of a contemporary cohort of patients on dialysis revealed that mortality from acute myocardial infarction (AMI) has decreased, whereas the prevalence of AMI has increased markedly, particularly among patients with non-ST elevation myocardial infarction (NSTEMI). Using inpatient discharge diagnosis codes (1993–2008), we determined that proportions of AMI claims decreased in the primary position (from 65% to 52%) but increased in the secondary position (from 35% to 48%). Proportions of NSTEMI codes increased remarkably in both the primary and secondary positions. The progressive increase in diagnostic claims for secondary AMI identifies a unique high-risk population and has important clinical, economic, and epidemiologic implications among patients on dialysis.
SÍNDROME DE BURNOUT EM FISIOTERAPEUTAS: UMA REVISÃO SISTEMÁTICA
Authors: Santos Cleide Lucilla Carneiro , Nascimento Sobrinho Carlito Lopes , Barbosa Gabriela Bene
Published: February 2017

Introdução: O estudo das relações entre o trabalho do fisioterapeuta e a síndrome de burnout constitui-se um desafio para se entender o processo saúde doença desse profissional, por ser pouco conhecido na literatura nacional e internacional. Objetivo: Descrever a produção científica existente na literatura sobre a prevalência da síndrome de burnout e os fatores associados em fisioterapeutas. Metodologia: Foi utilizado o portal de periódicos da BVS, no qual estão incluídas as bases de dados: MEDLINE (PubMed), IBECS e LILACS, considerando-se o período de janeiro de 1980 a março de 2016. Os critérios de inclusão foram: estudos com fisioterapeutas, originais, com delineamento transversal, populacionais e/ou amostrais, que utilizaram o Maslach Burnout Inventory (MBI) para a identificação da síndrome. Resultados: Dos 35 estudos encontrados que abordavam a síndrome de burnout na categoria fisioterapeuta, 13 estudos foram elegíveis para revisão, por atenderem os critérios de inclusão. Considerações Finais: Foi observado, na produção científica existente, uma heterogeneidade de achados de prevalência e de fatores associados ao burnout em fisioterapeutas. Sendo que não há consenso na literatura para a interpretação do questionário de Maslach. Observou-se ainda a adoção de variados pontos de corte para a definição das três dimensões do burnout. Sugere-se a adoção de uma interpretação consensual dos resultados do questionário de Maslach e a utilização de pontos de corte padronizados para a definição das dimensões da síndrome.
RISCO DE QUEDAS EM PACIENTES HOSPITALIZADOS
Authors: Marinho Giselle Soares , De Azevedo Alves Giovani Assunção , De Oliveira Daniela Fagundes , Fagundes Góes Ângela Cristina , Martinez Bruno Prata
Published: February 2017

Introdução: As quedas em pacientes hospitalizados tem associação  com consequências negativas, sendo um importante problema relacionado à segurança do paciente. Investigar o risco de queda em pacientes hospitalizados tem relevância, já que fornecerá subsídios para formulação de planos terapêuticos para sua prevenção. Objetivo: Mensurar o risco de quedas em uma amostra de pacientes hospitalizados. Métodos: Estudo transversal realizado com 100 pacientes em um hospital público de referência na cidade de Salvador-Bahia. O instrumento utilizado para mensuração desse risco foi a Morse Fall Scale (MFS), traduzida e adaptada para língua portuguesa. Resultados: A média de idade dos pacientes avaliados foi 59 anos, com predomínio do gênero feminino. Em relação aos motivos de internação, a principal causa foram os problemas neurológicas, seguidos de condições de pós-operatórios. A média do escore total da escala MFS foi 46,3; a qual indica um risco elevado de quedas. Não foi observado diferença estatística significante nos valores do escore total de Morse entre as variáveis gênero(feminino: 47,0±14,5; masculino: 45,2±18,5; valor de p:0,355), idade (idade<60 anos: 46,5±16,4; idade≥60 anos: 46,1±16,2; valor de p: 0,949) e motivo de admissão(Causas neurológicas: 44,7±17,1; causas não-neurológicas: 48,0±15,2; valor de p: 0,387). Conclusão: O risco de queda na amostra de indivíduos avaliados no ambiente hospitalar foi moderado a alto, o que demonstra a necessidade de intervenções preventivas por parte da equipe multiprofissional para não ocorrência de queda e suas complicações associadas.
CRIOLIPÓLISE: APLICABILIDADE CLÍNICA E PERSPECTIVAS DA TERAPÊUTICA NA ADIPOSIDADE LOCALIZADA - UMA REVISÃO SISTEMÁTICA
Authors: De Souza Santos Ferreira Rebeca Caroline , Medrado Alena Peixoto
Published: February 2017

Introdução: A criolipólise, apesar de ser um tratamento estético recentemente descrito na literatura, é uma opção terapêutica queapresenta fundamentos teóricos e práticos cujos resultados na redução da gordura localizada indicam serem positivos. Objetivo: Realizar uma revisão sistemática para relatar a aplicabilidade clínica da criolipólise e documentar a sua eficácia em pacientes com adiposidade localizada, no âmbito da Fisioterapia Dermatofuncional. Metodologia: Foram selecionados artigos científicos classificados como ensaios clínicos randomizados ou não nas bases de dados PubMed e Bireme entre os períodos de 2010 a 2016. A pesquisa foi conduzida conforme a metodologia PRISMA. Os manuscritos incluídos foram analisados qualitativamente segundo a escala JADAD e revisados por dois avaliadores independentes. Resultados: Dos 210 artigos identificados nas bases de dados, 9 manuscritos foram incluídos para análise, com amostra total de 234 indivíduos com adiposidade localizada. O nível dequalidade dos estudos foi 2,1. Diferentes áreas anatômicas foram avaliadas nos estudos compilados com ênfase para coxas, flancos, braços e abdômen. Observou-se também, um grau de satisfação alto por parte dos participantes.Conclusão: Concluiu-se que, o nível de qualidade dos ensaios clínicos existentes na literatura foi considerado baixo, a despeito do fato de serem publicados em periódicos de alto impacto. A randomização da amostra representou o ponto crítico para a maioria dos manuscritos. Sugere-se a realização de mais ensaios clínicos randomizados para o embasamento teórico e prático da técnica de criolipólise.
PHYSIOTHERAPY IN THE PATIENT WITH DISORDER OF SEXUAL DEVELOPMENT: FUNCTIONALITY AND AESTHETICS
Authors: Brasil Cristina Aires
Published: February 2017

A desordem da diferenciação sexual (DDS) é definida como uma condição congênita em que o desenvolvimento dos cromossomos, gônadas e a anatomia sexual são atípicas. Os pacientes com DDS apresentam repercussões ao longo da vida que perpassam por queixas que englobam componentes da funcionalidade do assoalho pélvico como: incontinência urinária, estreitamento vaginal, disfunções sexuais,  além da insatisfação com a aparência genital. Existem diferentes recursos que podem ser utilizados para reduzir estas repercussões no qual fazem parte do arsenal de recursos fisioterapêuticos, como os dilatadores vaginais e o uso da radiofrequência.  Contudo, a fisioterapia ainda não faz parte da equipe multidisciplinar exigida pelos guidelines de manejo ao paciente com DDS, devido a escassez de estudos que comprovem a evidência da fisioterapia nesses pacientes, porem baseados nos estudos desenvolvidos para o tratamento da aparência genital e funcionalidade do assoalho pélvico, torna-se possível a atuação deste profissional nesta população.
O USO DE APLICATIVOS MÓVEIS NAS DISFUNÇÕES PÉLVICAS
Authors: Moretti Eduarda Correia
Published: February 2017

A fisioterapia desempenha um papel fundamental dentro das opções de tratamento conservador para as disfunções do assoalho pélvico. Nesse contexto, a telerreabilitação associada ao conceito de mHealth surge como uma importante estratégia por envolver a possibilidade de conduzir uma terapia, avaliação ou treino à distância através de dispositivos móveis. É possível, então, observar dois segmentos de aplicativos móveis estabelecidos: o que disponibiliza uma releitura do tradicional diário miccional e o que direciona exercícios para a musculatura do assoalho pélvico. Buscas (outubro/2016) nas principais lojas de aplicativos móveis mostram diversos aplicativos que permitem que o usuário preencha informações diárias a respeito da ingesta de líquido, micções, perdas de urina e utilização de proteção higiênica. São muitos também os que buscam auxiliar a realização de exercícios para o assoalho pélvico. Contudo, esses aplicativos são de caráter informativo, mostrando apenas séries de exercícios a serem executadas. Alguns produtos foram lançados no mercado oferecendo sistemas integrados a aplicativos móveis que permitem uma interação em tempo real entre os exercícios do assoalho pélvico realizados pelos usuários e o aplicativo. Apesar de vários aplicativos disponíveis, buscas (outubro/2016) nas principais bases de dados da literatura científica em saúde mostraram a existência de apenas dois registros de estudos referentes ao aplicativo móvel denominado “Tät”, cujo objetivo é favorecer o tratamento da incontinência urinária de esforço. A partir de uma análise crítica dos estudos, é possível concluir que existem poucas evidências científicas que suportam a utilização de aplicativos móveis no tratamento de disfunções pélvicas.
Urban Forms and Future Cities: A Commentary
Authors: Angel Shlomo
Published: February 2017

The commentary reflects on the critical ways in which the proliferation of private property rights and local planning powers constrain and delimit the changes in the forms of cities that will be required in the coming years to ensure that they remain productive, inclusive, and sustainable. It argues that the effective management of the coming disruptions now require a shift of power from the private and the local to the metropolitan and the regional.
Formação técnica de professores do Ensino Médio para uso do Tablet Educacional: uma pesquisa-ação / Technical development of high school teachers for the use of the educational tablet: an action-research
Authors: Gonçalves Elivelton Henrique , Costa Fernanda de Oliveira , Araújo Adelma L.O.S
Published: February 2017

RESUMO:Este estudo tem como objetivo compreender a importância da formação contínua dos professores do Ensino Médio do CESEC (Centro Estadual de Educação Continuada) Augusta Raquel da Silveira, em Lagamar-MG, como uma forma de possibilitar a adoção de novas tecnologias, especificamente o Tablet Educacional, em suas propostas pedagógicas. Como método de trabalho, escolheu-se a pesquisa-ação. Assim, por meio da implantação de três ações – formação técnica, formação pedagógica e elaboração e desenvolvimento de um plano de aula utilizando o aparelho – foi possível apresentar aos professores da instituição conhecimentos técnicos e pedagógicos referentes ao manuseio do tablet, além de proporcionar a aplicação prática do aparelho, com as devidas orientações e suporte, na rotina educacional de cada profissional. A partir do desenvolvimento das ações, foi construído e sistematizado um conjunto de saberes inerentes ao Tablet Educacional, que contribuíram para que os professores conhecessem a relevância da sua utilização, de modo a usufruírem suas possibilidades e recursos que subsidiam, de forma significativa, o trabalho docente e o processo de ensino-aprendizagem.PALAVRAS-CHAVE: tecnologias na educação; formação de professores; formação contínua de professores. ABSTRACT:The present study aimed at understanding the importance of continuing development of CESEC’s (State Center of Continuing Education) Augusta Raquel da Silveira High School teachers in Lagamar, in the state of Minas Gerais, as a form of enabling the adoption of new technologies, especially the Educational Tablet, to their pedagogical purposes. The action-research was chosen as the method of work. Thus, through the implementation of three actions – technical training, pedagogical training, and elaboration and development of a lesson plan using the Educational Tablet –, it was possible to present to the school teachers technical and pedagogical knowledge about the tablet, promoting its practical use with the necessary guidance and support for their educational routine. From the development of the actions, a body of knowledge concerning the Educational Tablet was constructed and systematized, which contributed for the teachers to get to know it and understand how relevant it is to employ it so as to explore its possibilities and resources that significantly subsidize the teaching work and the teaching-learning process. KEYWORDS: technology in education; teacher development; continuing teacher development.