bluuebunny/crossref_metadata_2025 huggingface dataset:
TÜKETİCİLERIN GELİŞİME AÇIKLIK KİŞİLİK ÖZELLİĞİ İLE ONLINE ALIŞVERIŞLERDEKİ KARAR VERME TARZLARI ARASINDAKİ İLİŞKİ
Authors: Bilginer Fatma gül , Saltan Onur Fatih
Published: January 2020

Gün geçtikçe türlü online işlerle vakit
geçiren bireylerin sayısı artmaktadır.Birçok ürün ve hizmete ilişkin internet
üzerinden satın alım kararının verilmesi günümüzün önemli tüketim tarzları
arasında yer almaktadır. Bundan dolayı, pazarlama biliminin  en önemli araştırma konuları arasında online
tüketici davranışı da yer almıştır.Ancak online ortamın kendine has bazı
özellikler taşıması, tüketicinin bu ortamda karar verme tarzına da yeni bakış
açıları kazandırmıştır. Bu araştırmanın amacı, tüketicilerin gelişime açıklık
kişilik özelliği göz önünde bulundurarak, online alışveriş ortamında karar
verme tarzları arasındaki ilişkiye yönelik uygulamalı bir araştırma
gerçekleştirilmiştir. Kilis ilinde yaşayan 330 kişi araştırmanın örneklemini
oluşturmuş olup veri toplama aracı olarak anketten faydalanılmıştır.Analiz
kapsamında değişkenler arasında belirli kolerasyon ve regresyon analizleri
yapılmış olup elde edilen sonuçlara göre
tüketicilerin online karar verme tarzlarının her boyutunda gelişime açıklık
ölçeğinin yeniliklere açıklık boyutuyla ilişki olduğu ve buradan yola çıkarak
yeniliğe açık kişilerin online karar verme tarzları arasında pozitif ve anlamlı
bir ilişki olduğu söylenebilir. Bunun yanında kültürel gelişime açık
tüketicilerin sadece web sitesi içeriği ve ara yüze duyarlılık boyutları
ile  arasında pozitif ve anlamlı ilişki
olduğu görülmüştür.
İÇGİRİŞİMCİ DAVRANIŞI: ÖLÇEK GELİŞTİRME, GÜVENİLİRLİK VE GEÇERLİLİK ÇALIŞMASI
Authors: SEZGİN Oytun
Published: January 2020

Bağlı bulundukları kurumlardaki bireylerin teşvikler ya da kendi
inisiyatifleri doğrultusunda, bulundukları kurumdan ayrılmadan
gerçekleştirdikleri girişimsel faaliyetler bütünü şeklinde tanımlanan
içgirişimci davranışı, işletmelerin rekabet avantajı elde etmesine katkıda
bulunmaktadır. İlgili yazında işletmeler açısından önem arz eden içgirişimci
davranışı olgusunun, bütüncül değerlendirilerek geliştirilen bir ölçek
eksikliği dikkat çekmektedir. Bu çalışmanın amacı, içgirişimci olgusunun bütün
boyutları ile değerlendirerek içgirişimci davranışı için bir ölçme aracı
geliştirmektir.  Bu bağlamda çalışma;
kapsam geçerliliği, yapı geçerliliği ve ölçek güvenilirliği aşamalarını
içermektedir.

Çalışmada oluşturulan 23 maddelik soru formu İzmir’deki özel sektörde
çalışan 207 kişi üzerinde test edilmiştir. Gerçekleştirilen açımlayıcı ve
doğrulayıcı faktör analizleri sonucunda içgirişimci davranışı ölçeği; yenilikçilik,
rekabetçilik, destekleyicilik, inisiyatif alma, bilgi edinimi ve proaktiflik
olmak üzere 6 boyuttan oluşmaktadır. Geliştirilen ölçeğin ilgili yazına ve
olgunun algılanmasına dönük yapılacak açıklayıcı çalışmalara katkı sağlayacağı
düşünülmektedir. Ayrıca, özgün bir ölçek ile gerçekleştirilen çalışmaların da
politika yapıcılara ve uygulamacılara destek olması beklenmektedir.
LOJİSTİK İŞLETMELERİNİN PAZARLAMA YETENEKLERİNİN REKABET AVANTAJI VE İŞLETME PERFORMANSINA ETKİSİ
Authors: KOBAN Engin , EKER İŞCİOĞLU Tutku
Published: January 2020

Artan Dünya ticaret hacmi ile birlikte rekabet
düzeyinin arttığı lojistik sektöründe faaliyet gösteren işletmelerin
sürdürülebilir rekabet avantajı elde edebilmek için yeteneklerini gözden
geçirmeleri zorunlu hale gelmiştir. Bu yeteneklerden en temel olanlardan birisi
de kuşkusuz pazarlama yetenekleridir. Araştırma, rekabet avantajı sağlamanın önemli
bir çıktısı olan işletme performansına pazarlama yeteneklerinin ve bu
yeteneklerin önemli girdilerinden örgütsel kaynaklar ve örgütsel yeteneklerin
etkisini araştırmayı amaçlamaktadır. Bu çerçevede oluşturulan kavramsal modelde
ilk aşamada pazarlama yeteneklerinin örgütsel kaynaklar ve örgütsel yetenekler arasındaki
ilişkisi değerlendirilmiş, ikinci aşamada ise pazarlama yetenekleri ve rekabet avantajı
arasındaki etkileşim ve her ikisinin de işletme performansı üzerinde yarattığı
etki test edilmiştir. 42 lojistik hizmet sağlayıcı işletmeden elde edilen
veriler ile Kısmi En Küçük Kareler Yöntemi - Yapısal Eşitlik Modellemesi ile
test edilen hipotezler, işletme performansı üzerinde sadece rekabet avantajının
doğrudan etki yarattığını göstermektedir. Örgütsel kaynaklar ve yetenekler ile
pazarlama yetenekleri, rekabet avantajının aracı değişken vazifesi görmesi ile işletme
performansını dolaylı olarak etkilemektedir.
MOBİL REKLAMLARA YÖNELİK TUTUM VE DAVRANIŞLAR: ÜNİVERSİTE ÖĞRENCİLERİ ÜZERİNE BİR ARAŞTIRMA
Authors: KAHRAMAN Aysun , GÜVEN Esra
Published: January 2020

Yüksek hızlı
internet teknolojilerinin ortaya çıkması ve akıllı telefon kullanımının artması
reklam endüstrisini etkilemiş, mobil reklamlar medya kanalları arasında yerini
almıştır.  Mobil reklam kampanyalarına
yönelik yatırımlar arttıkça bu alanda araştırma yapma ihtiyacı da artmaktadır.
Akıllı telefon ve mobil teknolojilere olan ilgilerinin yüksek olması nedeniyle özellikle
genç tüketicilerin aynı ilgiyi mobil reklamlara gösterip göstermediği merak
konusudur. Bu noktadan hareketle bu çalışmada üniversite öğrencilerinin mobil
reklamlara yönelik tutumları ve mobil reklamları benimseme davranışları
incelenmiştir. Mobil reklamları benimsemeyi etkileyeceği düşünülen
değişkenlerden yola çıkarak bir model oluşturulmuştur. 360 üniversite
öğrencisinden anket yöntemiyle toplanan veriler SPSS 23.0 ve LISREL 9.30
programlarında analiz edilmiştir. Analiz sonuçlarına göre akıllı telefonlar en
çok müzik dinlemek, sosyal ağları takip etmek ve video izlemek amacıyla
kullanılmaktadır. Mobil reklamlara yönelik tutum olumsuzdur. Mobil reklamların
benimsenmesinde reklamların eğlenceli bulunmasının ve reklamlardan hoşlanmanın
doğrudan etkisi vardır. Mobil reklamları eğlenceli bulmak, mobil reklamların
faydalı olduğunu düşünmek mobil reklamlardan hoşlanmayı olumlu yönde
etkilerken, mobil reklamlardan rahatsızlık duymak hoşlanmayı olumsuz yönde
etkilemektedir.
Preoperative serum thyroglobulin levels as a predictor of thyroid carcinoma
Authors: Hassan Mir Mohammed Noorul , Kattimani Prakash S. , Saniya Aeiman
Published: January 2020

Background: Incidence of thyroid nodules varies according to the methods of diagnosis, 4-7% by palpation and 17-67% by high resolution ultrasound. The gold standard of diagnosis for thyroid nodules is fine needle aspiration (FNA); however, fine needle aspiration cytology (FNAC) alone is insufficient to detect cancer because of inadequate cytology (5-15%) and in cases of follicular neoplasm (15-25%) where only surgery is diagnostically conclusive. Therefore, other factors in addition to FNA should be considered to predict malignancy. This study was done to evaluate the association between elevated pre-operative thyroglobulin levels and histopathologically proven thyroid carcinoma.Methods: This retrospective study was conducted in Bowring and Lady Curzon Hospital, from December 2017 to November 2018. All patients above 18 years, undergoing total thyroidectomy, with normal antithyroglobulin levels and with indeterminate thyroid nodules or disease on FNAC were included. Patients proven to have malignancy by FNAC, who underwent hemithyroidectomy and patients with thyroglossal cyst or ectopic thyroid swellings were excluded.Results: A total of 50 patients were included. The Fischer’s exact test shows significant value of 0.037 and also the two-tailed test showed a p value <0.05, hence it is significant to conclude that the mean value of thyroglobulin levels among histopathologically proven malignant thyroid cancers is significantly higher compared to the benign thyroid disease.Conclusions: In addition to thyroid-stimulating hormone, thyroid nodules with elevated thyroglobulin levels were independently associated with the presence of thyroid cancer; therefore, the evaluation of pre-operative thyroglobulin level in patients with indeterminate FNAC might give additional information to predict malignancy.
A prospective study to find the prevalence of domestic violence against married females of rural India
Authors: Pundkar Rutuja Dinkar
Published: January 2020

Background: Starting from Vedic age to twenty first century, women have never been given equal freedom as of males. It is always the women who have to be on the tight rope, subject to inequality and looked down as an inferior sex. The aim and objective of the study was to estimate the prevalence of domestic violence.Methods: 776 married females were selected by systematic random sampling from the field practice area under primary health care. Prior a pilot study was carried out among 25 married class IV female workers. A predesigned and pretested questionnaire was used and all the confidentiality was maintained. Statistical analysis was done using SPSS 21 software.Results: Average age of the respondents was 28.13 years with range 18 to 56 years. Overall 96% respondents were literate, whereas literacy rate in rural population in parent district was 67.8%. Majority number of respondents were housewives i.e. 58.37%.Conclusions: Various sociodemographic factors like age of the women, education of women and perpetrator, age at marriage of women, and the socio-economic status shows inverse relationship with occurrence of domestic violence. More economic empowerment, along with higher education, may provide women with the ground of awareness protesting platform eventually promoting protective factors against domestic violence.
Temel Duygusal Yüz İfadelerinin Zaman Algısı Üzerindeki Etkisi
Authors: ERDOĞAN Şengül , BARAN Zeynel
Published: January 2020

Amaç: Bu çalışmanın amacı, evrensel olarak kabul edilen 6
temel duyguya ait yüz ifadelerinin sunum süresi değişimlenmesinin zaman algısı
üzerindeki etkisini, zaman aralığı yeniden oluşturma ve süreyi sözel tahmin
etme yöntemleri aracılığıyla incelemektir.Yöntem: Araştırma, dört farklı sunum süresinde (500, 1000, 1500
ve 2000 ms) sunulan yüz ifadelerinin (kızgınlık, korku, üzüntü, tiksinme,
şaşkınlık, mutluluk ve nötr) sözel olarak tahmin edilmesi ve yeniden
üretilmesini içeren iki farklı yöntemle 75 gönüllü öğrenci (47 Kadın ve 28
Erkek) ile yürütülmüştür. 

Bulgular: Her bir sunum süresinde, tüm duygusal yüz ifadeleri
hedef süreye göre kısa algılanmakta ve sunum süresi artıkça zamansal bozulmalar
artmaktadır. Öte yandan, tüm duygusal yüz ifadeleri, üzüntü yüz ifadesi hariç,
nötr yüz ifadesinden daha uzun algılanmaktadır. Bununla birlikte, tüm uyarıcı
süreleri, zaman aralığı yeniden oluşturma görevinde, süreyi sözel tahmin etme
görevine göre daha uzun algılanmaktadır.Sonuç: İçsel saat modeli ile dikkat ve genel uyarılmışlık düzeyi bağlamında, yüz
ifadelerinin hedef süreye göre kısa algılanması dikkat kaynaklı modelle; nötre
göre daha uzun algılanması ise genel uyarılmışlık düzeyi kaynaklı modelle daha
uyumlu görünmektedir. Duygusal yüz ifadelerinin zaman algısı üzerindeki
etkisinde, genel uyarılmışlık düzeyi ve dikkat kaynaklı ortak etkilerin yanı
sıra, zamansal yöntem türlerindeki farklılıklardan kaynaklanan bellek ve karar
verme süreçleri de etkili olabilmektedir.
Open to Open? An Exploration of Textbook Preferences and Strategies to Offset Textbook Costs for Online Versus On-Campus Students
Authors: Anderson Talea , Cuttler Carrie
Published: January 2020

As open textbook initiatives are on the rise, a burgeoning literature has begun exploring student perceptions of openly licensed textbooks used in higher education. Most of this research has lacked consideration of potential differences in the perceptions of online and on-campus students and has failed to include a control group of students using traditional textbooks. Therefore, the authors employed a 2 x 2 design to directly compare perceptions of online students with on-campus students assigned either open or traditional textbooks. Students (N = 925) enrolled in multiple sections of psychology courses at a midsized R1 institution completed a survey on their perceptions of their particular book’s format and features, as well as strategies they typically employ to offset the cost of expensive course materials. The results revealed that online and on-campus students report disparate strategies for offsetting the high costs of textbooks, different preferences in textbook formats (print versus digital versus both) when cost is not a factor, and differences in their ratings of the importance of various textbook features. Moreover, the results indicate that the use of open textbooks may increase preference for free digital textbooks over paid printed textbooks. Based on these results, the authors suggest that campuses might consider providing customized support to different student populations as open textbook initiatives gain in popularity on university campuses. Additionally, they suggest that prior exposure to open textbooks may increase students’ willingness to use openly licensed materials in future courses. They recommend future research on this question, using a longitudinal within-subjects designs.
Getting Started With Open Badges and Open Microcredentials
Authors: Clements Kyle , West Richard Edward , Hunsaker Enoch
Published: January 2020

This article is intended as a practical resource to help interested organizations design and implement an open badging system. Open badges are a type of open credential designed to recognize a variety of skills, knowledge, and experiences, both inside and outside of traditional educational settings. While growing in popularity, common questions asked by those interested in using open badges include: How do I get started? What technologies exist to produce open badges? And what do I need to know? This article seeks to address questions such as these. First, we introduce the reader to key terms in the badging world and explore open badge design precedents, responding to who, what, how, where, and why open badges have been used in the past. Drawing on this research as well as our own personal experience, we then present a possible framework for getting started with open badges and a step-by-step guide for implementing that framework within your organization.
Sun protection education for adolescents: A feasibility study of a wait-list controlled trial of an intervention involving a presentation, action planning, and SMS messages and using objective measurement of sun exposure
Authors: Hubbard Gill , Cherrie John , Gray Jonathan , Kyle Richard G , Nioi Amanda , Wendelboe-Nelson Charlotte , Cowie Hilary , Dombrowski Stephan
Published: January 2020

Background
People increase their risk of melanoma unless they are protected from the harmful effects of sun exposure during childhood and adolescence. We aimed to assess the feasibility of a three-component sun protection intervention- presentation, action planning, and SMS messages - and trial parameters.
Methods
This feasibility wait-list trial was conducted in the United Kingdom in 2018. Students aged 13-15 years were eligible. Feasibility outcomes were collected for recruitment rates; data availability rates for objective measurements of melanin and erythema using a Mexameter and self-reported sunburn occurrences, severity and body location, tanning, sun protection behaviours and Skin Self-Examination (SSE) collected before (baseline) and after the school summer holidays (follow-up); intervention reach, adherence, perceived impact and acceptability. Quantitative data were analysed using descriptive statistics; qualitative data were analysed thematically.
Results
Five out of eight schools expressing an interest in participating with four allocated to act as intervention and one control. Four parents/carers opted their child out of the study. 487 out of 724 students on the school register consented to the study at baseline (67%). 385 were in intervention group schools. Objective skin measurements were available for 255 (66%) of the intervention group at baseline and 237 (61%) of the group at follow up. Melanin increased; erythema decreased. Complete self-report data were available for 247 (64%) students in the intervention group. The number of students on the school register who attended the presentation and given the booklet was 379 (98%) and gave their mobile phone number was 155 (40%). No intervention component was perceived as more impactful on sun protection behaviours. Adolescents did not see the relevance of sun protection in the UK or for their age group.
Conclusions
This is the first study to use a Mexameter to measure skin colour in adolescents. Erythema (visible redness) lasts no more than three days and its measurement before and after a six week summer holiday may not yield relevant or meaningful data. A major challenge is that adolescents do not see the relevance of sun protection and SSE.
Determinants of long acting contraceptive utilization among hiv positive reproductive age women attending care at art clinics of public health facilities in Arba Minch town, Southern Ethiopia, 2019. A case control study
Authors: Yirsaw Betselot , Meskel Feleke G , Michael G-kiros G , Shitemaw Tewoderos
Published: January 2020

Background: Long acting and permanent contraceptive methods by far are the most effective, very safe and convenient methods than short acting contraceptive methods. Dual protective which includes use of a reliable hormonal contraceptive method like LAPMs and a barrier method like using the male or female condom is encouraged to prevent further transmission of HIV. But in less developed countries, use of long acting reversible contraceptive or permanent methods (LARCs/PMs) is very low. Therefore the aim of this study was to identify determinants of long acting contraceptive method utilization among HIV positive reproductive age women. Methods: An institutional based case control study was conducted among random sample of 354 HIV positive reproductive age women (total of 97.8% response rate) at Anti-Retroviral Therapy clinics from February 20 to March 20, 2019. Case to control ratio was 1:2. A structured questionnaire and information recorded from ART card review were used to collect the data. Bivariate and Multivariable logistic regression analysis were performed in order to identify the factors significantly associated with long acting contraceptive method utilization at the level of significance of p value <0.25 with 95% CI of COR and <0.05 with 95% CI of AOR respectively.Results: A total of 354 (33.3% cases and 66.7% controls) HIV positive reproductive age women were interviewed with response rate of 97.8%. The study revealed being in age group of 39 and above [AOR=0.17, 95% CI (0.06, 0.48)], being divorced/separated and widowed [AOR=0.05, 95% CI (0.003, 0.61)], having supportive opinion and strongly supportive opinion regarding family planning service availability in ART clinic [AOR= 5.01, 95% CI (1.79, 14.07)], [AOR= 7.81, 95% CI (2.54, 24.01)] and having no future fertility intention [AOR= 7.03, 95% CI (2.73, 18.06)] were statistically significant determinants for long acting contraceptive method utilization.Conclusion: Woman in age group of 39 and above, having no future fertility intention and being divorced/separated and widowed was found to be determinants of long acting contraceptive method utilization among HIV positive reproductive age women. In addition our study support the WHO Strategic Considerations for Strengthening the Linkages between Family Planning and HIV/AIDS Policies, Programs, and Services. Key words: - long acting contraceptive methods, HIV positive reproductive age women, Ethiopia
CRRT in patients with HIV/AIDS
Authors: Guo Hebing , Liu Jingyuan , Pu Lin , Hao Jingjing , Yin Ningning , Liu Yufeng , Xiong Haofeng , li ang
Published: January 2020

Background: AKI is a common complication among human immunodeficiency virus (HIV)--infecting patients and resulting in increased morbidity and mortality. CRRT is a useful method and instrument in critically ill patients with fluid overload and metabolic disarray, especially in those who are unable to tolerate the intermittent hemodialysis. However, the epidemiology, influence factors of CRRT and mortality in patients with HIV/AIDS are still unclear in China. This study aims to study the HIV-infected patients admitted in ICU and explore the influence factors correlated with CRRT and prognosis.Methods: We performed a retrospective case-control study, in ICU of Beijing Ditan Hospital Capital Medical University, which is a top three hospital majoring in infectious diseases. From June 1,2005 to May 31,2017, 225 cases were enrolled in this research eventually.Results: 122(54.2%) patients were diagnosed with AKI during their stay in ICU, the number and percentage of AKI stage 1/2/3 were respectively 38(31.1%)/23(18.9%)/61(50%). 26.2% of AKI patients received CRRT during the stay of ICU. 56.25% CRRT patients died in ICU. The 28-day mortality was 62.5%, and the 90-day mortality was 75%. By multivariate logistics analysis, it showed that the use of vasoactive agents (OR=174.31,95% CI 1.743-65.271, p=0.018), diagnosis of PCP(OR=27.136,95% CI 1.855-397.066, p=0.016) and longer duration of CRRT (OR=1.034,95% CI 1.004-1.065, p=0.028) were independent risk factors for predicting patients’ death of CRRT in ICU. The Cox Analysis for the cumulative survival of AKI 3 patients between the CRRT and non-CRRT groups shows no significant differences (p =0.309).Conclusions: The incidence of AKI was 54.2% in HIV-infected patients admitted to the ICU, and about 26.2% AKI patients received CRRT during the stay of ICU.56.25%CRRT patients died in ICU. The 28-day mortality was 62.5%, and the 90-day mortality was 75%. The use of vasoactive agents, diagnosis of PCP were independent risk factors for predicting patients’ death of CRRT in ICU. The cumulative survival of AKI 3 patients between CRRT and non-CRRT groups shows no significant differences.
Better efficacy in differentiating WHO grade II from III oligodendrogliomas with machine-learning than radiologist’s reading from conventional T1 contrast-enhanced and fluid attenuated inversion recovery images
Authors: Zhao Sha-Sha , Feng Xiu-Long , Hu Yu-Chuan , Han Yu , Tian Qiang , Sun Ying-Zhi , Zhang Jie , Ge Xiang-Wei , Cheng Si-Chao , Li Xiu-Li , Mao Li , Shen Shu-Ning , Yan Lin-Feng , Cui Guang-Bin , Wang Wen
Published: January 2020

Abstract
Background: The medical imaging to differentiate World Health Organization (WHO) grade II (ODG2) from III (ODG3) oligodendrogliomas still remains a challenge. We investigated whether combination of machine leaning with radiomics from conventional T1 contrast-enhanced (T1CE) and fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI) offered superior efficacy.
Methods: Thirty-six patients with histologically confirmed ODGs underwent T1CE and 33 of them underwent FLAIR MR examination before any intervention from January 2015 to July 2017 were retrospectively recruited in the current study. The volume of interest (VOI) covering the whole tumor enhancement were manually drawn on the T1CE and FLAIR slice by slice using ITK-SNAP and a total of 1072 features were extracted from the VOI using 3-D slicer software. Random forest (RF) algorithm was applied to differentiate ODG2 from ODG3 and the efficacy was tested with 5-fold cross validation. The diagnostic efficacy of radiomics-based machine learning and radiologist’s assessment were also compared.
Results: Nineteen ODG2 and 17 ODG3 were included in this study and ODG3 tended to present with prominent necrosis and nodular/ring-like enhancement (P < 0.05). The AUC, ACC, sensitivity, and specificity of radiomics were 0.798, 0.735, 0.672, 0.789 for T1CE, 0.774, 0.689, 0.700, 0.683 for FLAIR, as well as 0.861, 0.781, 0.778, 0.783 for the combination, respectively. The AUCs of radiologists 1, 2 and 3 were 0.700, 0.687, and 0.714, respectively. The efficacy of machine learning based on radiomics was superior to the radiologists' assessment.
Conclusions: Machine-learning based on radiomics of T1CE and FLAIR offered superior efficacy to that of radiologists in differentiating ODG2 from ODG3.
Radix Stephaniae Tetrandrine: An Emerging Role for Management of Breast Cancer
Authors: Guo Yubo , Chen Beibei , Pei Xiaohua , Zhang Dongwei
Published: January 2020

Background:

Radix Stephaniae Tetrandrine (RST), known as FangJi (Pinyin name) in Chinese, is the
dried root of Stephania tetrandra S.Moore, and has been prescribed in combination with other herbs to treat cardiovascular
diseases and breast cancer in traditional Chinese medicine (TCM) clinical trials.

Objective:

The aim of the review is to provide a comprehensive evaluation about the application of RST in breast
cancer management in TCM clinical trials, its ingredients, and its action on preventing the development of breast
cancer in vitro and in vivo studies.

Methods:

Literature sources used were Pubmed, CNKI.net, Cqvip.com, and the Web of Science. For the inquiry,
keywords such as Fangji, breast cancer, clinical trials, Radix Stephaniae Tetrandrine, tetrandrine, and fangchinoline
were used in various combinations. About 150 research papers and reviews were consulted.

Results:

In TCM, RST exhibited the anti-tumor ability through its action on the bladder and lungs through dispersing
phlegm and blood stasis. 10 clinical trials were identified which used RST in combination with other
herbs to treat breast cancer. On average, the trials were characterized by high efficacy (>85%) and low toxicity.
However, most of the clinical trials are characterized as small patient samples, poor design, and different combinations
of herbs in prescriptions. To date, more and more compounds have been isolated from this plant. RST
exhibited anti-tumor activities by targeting reversing multidrug resistance, inhibiting cell proliferation, inducing
apoptosis, preventing tumor angiogenesis, anti-oxidation, anti-inflammation, and enhancing the sensitization and
attenuating the toxicity of radiotherapy.

Conclusion:

The successful applications of RST in TCM clinical trials and preclinical experiments to beating
breast cancer will provide potent lead compounds in the identification of novel anti-cancer drugs, which further
contributes to the scientific exploration of functions of RST in TCM.
Application of Chiral Isocyanides in Multicomponent Reactions
Authors: Vavsari Vaezeh Fathi , Shakeri Pegah , Balalaie Saeed
Published: January 2020

As one of the most important building blocks in organic synthesis, isocyanides come in for a wide range of transformations owing mostly to their unusual terminal carbon center adsorbed electrophiles, reacted with nucleophiles, get involved in radical reactions and coordinated with metal centers. The distinctive feature of isocyanide is its ready willingness to participate in multicomponent reactions (MCRs). MCRs represent a great tool in organic synthesis for the construction of new lead structures in a single procedure introducing both structural diversity and molecular complexity in only one step. Isocyanide-based multicomponent reactions (IMCRs) have become a powerful approach for the synthesis of complex molecules providing high degree of atom and bond economy under very mild reaction conditions. The use of enantiomerically pure isocyanides can, in principle, bring about two advantages: (i) the possibility to obtain a stereochemically diverse adduct, controlling the absolute configuration of the starting isocyanide; and (ii) the possibility to induce diastereoselection in the multicomponent reaction. The most commonly-used IMCRs are the Ugi and Passerini reactions. Many published reviews have focused on the Ugi and Passerini reactions from different viewpoints, but this review describes advances in the application of chiral isocyanides in MCRs. The rationale for applying such diversity generating chemistries is also discussed.
Clinical Relevance of Alternative Lengthening of Telomeres in Cancer
Authors: da Silva Guilherme G. , Morais Karollyne S. , Arcanjo Daniel S. , de Oliveira Diêgo M.
Published: January 2020

The alternative lengthening of telomere (ALT) is a pathway responsible for cell immortalization in some kinds of tumors. Since the first description of ALT is relatively recent in the oncology field, its mechanism remains elusive, but recent works address ALT-related proteins or cellular structures as potential druggable targets for more specific and efficient antitumor therapies. Moreover, some new generation compounds for antitelomerase therapy in cancer were able to provoke acquisition of ALT phenotype in treated tumors, enhancing the importance of studies on this alternative lengthening of the telomere. However, ALT has been implicated in different – sometimes opposite – outcomes, according to the tumor type studied. Then, in order to design and develop new drugs for ALT+ cancer in an effective way, it is crucial to understand its clinical implications. In this review, we gathered works published in the last two decades to highlight the clinical relevance of ALT on oncology.
A Review on the Synergetic Effect of Plant Extracts on Nanomaterials for the Removal of Metals in Industrial Effluents
Authors: Vishnu Dhanya , Dhandapani Balaji
Published: January 2020

Aim:

The review paper aims to explore the effect of plant extracts on nanomaterial adsorbent
for the removal of toxic metals present in industrial effluents.

Background:

Water plays a major role in the sustainability of human life and its existence. Rapid industrialization
and urbanization lead to an increase in the pollution and accumulation of hazardous
substances which causes the degradation of the aquatic ecosystem. Heavy metals are considered to be
a major threat to the environment. Among various metals, the International Union of Pure applied
chemistry (IUPAC) has characterized heavy metals based on their intensity of toxicity and hazardous
effects. Nanoparticles, due to their unique properties of particle size, exist in the range between 1-
100nm, which represents the possibility to introduce modified chemical groups on their surface functioning
as capping agents. Nanoparticles with the increased surface area have specified functional
groups which induce the capability of the catalytic reduction reaction and their optical characteristics
impact the industrial, agricultural and environmental sectors.

Objective:

Magnetic nanoparticles incorporated with the enzymes and metallic sites have been widely
used in both the synthesis of bio valuable products as well as in the degradation of many hazardous
substances like dyes, phenolic compounds, etc. Also, they are used in the removal of metal ions
present in wastewater.

Methods:

Superparamagnetic support nanomaterials (SPIONs) are prepared using the compounds of
Fe, Cu, Ni, Mn and Mg for the distinct and unique characteristics of reusability. These metallic nanomaterials
are coated with distinct materials like mesoporous and amorphous silica, polyvinyl alcohol
and pyrrolidine, polyethylene glycol, polystyrene, chitosan, dextran, starch, gelatin, polystyrene,
polyacrylic acid, and polymethyl methacrylate to enhance the stability of the nanomaterials.

Results:

In comparison to the different nanomaterials, metal oxide NPs possess increased stability,
magnetic inertness, optical and electrical properties. Nanomaterials that are used in the medical applications
are also used as the adsorbents to remove heavy metals from the industrial wastewater. The
presence of polyphenolic compounds and flavonoids makes the plant extracts effective antimicrobial
agents that impact pathogens. Moreover, these plant extracts, coupled with other nanomaterials, play
a significant role in the removal of toxic pollutants from the environment.

Conclusion:

Polyphenolic compounds present in plant extract function as natural reducing agents;
hence, integrating plant extract with metal/metal oxide nanoparticles proves to be efficient in comparison
with the catalysts synthesized by using other chemical methods. These surface modified
nanocatalysts tend to possess enhanced stability and specific reactivity in the system and are used in
the elimination of organic and inorganic pollutants in the industrial wastewater.
Chemo-enzymatic Synthesis of 3′-azido/-amino-C-4′-spirooxetano-xylo nucleosides
Authors: Kumar Manish , Kumar Rajesh , Rana Neha , Prasad Ashok K.
Published: January 2020

Conformationally locked 3'-azido-C-4'-spirooxetano-xylonucleosides T, U, C and A have been synthesized by following chemo-enzymatic convergent route. One of the 3'-azido-C-4'- spirooxetano-xylonucleosides, i.e. T was converted into 3'-amino-C-4'-spirooxetano-xylothymidine by reduction of azide to amine with H2/Pd-C in ethyl acetate in quantitative yield. The crucial step in the synthesis of spirooxetano-xylonucleosides is the Lipozyme® TL IM-mediated exclusive diastereoselective acetylation of 4-C-hydroxymethyl group in dihydroxysugar derivative, 3-azido-3-deoxy-4-Chydroxymethyl- 1,2-O-isopropylidene-α-D-xylofuranose in quantitative yield. The diastereoselective monoacetylation of 4-C-hydroxymethyl in dihydroxysugar derivative was unambiguously confirmed by X-ray crystal study on the tosylated compound obtained by the tosylation of Lipozyme® TL IM - mediated monoacetylated sugar derivative. The broader substrate specificity and exclusive selective nature of Lipozyme® TL IM can be utilised for the development of environmentally friendly methodologies for the synthesis of different sugar-modified nucleosides of importance.
The english material needs of economics and business students
Authors: Krismayani Ni Wayan , Suastra I Made , Suparwa I Nyoman , Sudipa I Nengah
Published: January 2020

This paper aims to describe the analysis of the English Course for Economics and Business students focus on target needs and learning needs. This study involved 260 students from 4 universities in Bali. Data were obtained from questionnaires and interviews. The data which had been collected were then tabulated and analyzed by using descriptive method. The findings of this study showed that conducting needs analysis to ESP course is important as the basis for designing syllabus and material because there was no material available on the market that could fully fit the students’ needs. The economics topic was needed by the students (47%) and (53 %) got difficulty in recognizing core words, and interpret patterns or sequences of words and their meanings systematically. There were 46% of students want to improve their macro skill especially in detecting discourse markers, guessing the meaning of words from context, and activating schemata to interpret the text. The input needed by students was a business text (42 %). Pair work as a procedure desired by the students (35 %). Moreover, having group work as a setting (41%) and (38 %) felt that the lecturer must give an example on the instruction and assignment.
Media anthropology: studying the life of media consumers through audience ethnography
Authors: Rofil Lily El Ferawati
Published: January 2020

Editorial
Efficacy of the Digital Therapeutic Mobile App BioBase to Reduce Stress and Improve Mental Well-Being Among University Students: Randomized Controlled Trial
Authors: Ponzo Sonia , Morelli Davide , Kawadler Jamie M , Hemmings Nicola Rose , Bird Geoffrey , Plans David
Published: January 2020

Background

University students in the United Kingdom are experiencing increasing levels of anxiety. A program designed to increase awareness of one’s present levels of well-being and suggest personalized health behaviors may reduce anxiety and improve mental well-being in students. The efficacy of a digital version of such a program, providing biofeedback and therapeutic content based on personalized well-being metrics, is reported here.

Objective

The aim of this study was to test the efficacy and sustained effects of using a mobile app (BioBase) and paired wearable device (BioBeam), compared with a waitlist control group, on anxiety and well-being in university students with elevated levels of anxiety and stress.

Methods

The study employed a randomized, waitlist-controlled trial with assessments at baseline, 2 weeks, postintervention (4 weeks), and follow-up (6 weeks). Participants were eligible if they were current full-time undergraduate students and (1) at least 18 years of age, (2) scored >14 points on the Depression, Anxiety, and Stress Scale-21 items (DASS-21) stress subscale or >7 points on the DASS-21 anxiety subscale, (3) owned an iOS mobile phone, (4) did not have any previous psychiatric or neurological conditions, (6) were not pregnant at the time of testing, and (7) were able to read and understand English. Participants were encouraged to use BioBase daily and complete at least one course of therapeutic content. A P value ≤.05 was considered statistically significant.

Results

We found that a 4-week intervention with the BioBase program significantly reduced anxiety and increased perceived well-being, with sustained effects at a 2-week follow-up. Furthermore, a significant reduction in depression levels was found following the 4-week usage of BioBase.

Conclusions

This study shows the efficacy of a biofeedback digital intervention in reducing self-reported anxiety and increasing perceived well-being in UK university students. Results suggest that digital mental health interventions could constitute a novel approach to treat stress and anxiety in students, which could be combined or integrated with existing therapeutic pathways.

Trial Registration

Open Science Framework (OSF.io) 2zd45; https://osf.io/2zd45/
Pembasmi Obligat Hama Tikus Dari Ampas Teh Terhadap Pertumbuhan Dan Tingkat Mortalitas Rattus norvegicus
Authors: Amila Hadita , Afifah Nurul , Ramaidhani Ramaidhani , Fitriani Fitriani
Published: January 2020

Rat as one of the important pests that attackcrops in Indonesia. This pest attacks food crops in all phases of growth so that it can cause a considerable decrease in crop yields. So it is necessary to eradicate rat pests by using politicians from tea pulp. The purpose of this study was to determine how the influence of political use on rat growth and mortality. The design used is RAL which consists of 5 treatments, namely 0 ml/L, 3 ml/L, 6 ml/L, 9 ml/L, and 12 ml/L. The parameters observed were: mortality, weight, and appetite for mice. Data analysis using ANOVA at 5% significance level and continued with DMRT. The results showed that there was an influence of obligat rat pest use on body weight, appetite, and mortality of mice, obligat rat pest who effectively increased mortality reduced rat body weight, rat appetite and rat mortality in the treatment of 12 ml/L.
Analytical Study of Circulation and Space Arrangement of Baiturrahman Grand Mosque Based on Gender According to Islamic Sharia Analysis
Authors: Fakriah Nurul
Published: January 2020

The mosque is a Muslim worship building that is commonly found in Muslim-populated areas. As the main building in Islam, with its significant role, it is relevant if the mosque building applies Islamic concepts in its spatial arrangement and circulation. One of them is the concept of gender-based spatial arrangement. However, in the mosque's spatial arrangement and circulation, it is often found that the arrangement is not in accordance with the Islamic principles. This causes discomfort for some building users. This study revealed an analysis of circulation and spatial arrangement in the Baiturrahman Grand Mosque building, the largest mosque in Banda Aceh, which became an icon of the city of Banda Aceh. This study is also carried out based on gender in accordance with Islamic sharia. Using the qualitative approach, observation being carried out as well as the study of Islamic source and Ching’s theory of circulation. The result shows that there is still a potential of ikhtilath (mingled each other between genders) happened in the recent space arrangement and circulation of the Baiturrahman Grand Mosque.
Edible Film dari Karaginan (Eucheuma cottonii) Asal Aceh, Indonesia : Karakterisasi dengan FTIR dan SEM
Authors: Nasution Reni Silvia , Harahap Muhammad Ridwan , Yahya Husnawati
Published: January 2020

Edible film karaginan merupakan salah satu alternatif pengganti kemasan plastik yang sulit terdegradasi di alam dan aman bagi bahan pangan. Karaginan merupakan hasil ekstraksi salah satu jenis rumput laut yaitu Eucheuma cottonii. Tujuan penelitian ini untuk mengetahui gugus fungsi dari edible film dengan variasi konsentrasi karaginan dan sifat permukaan dari edible film karaginan dengan SEM. Pemanfaatan karaginan hasil ekstraksi E.cottonii asal Aceh untuk pembuatan edible film diharapkan dapat meningkatkan potensi budidaya E.cottonii di Aceh. Tahapan penelitian dilakukan dengan dua tahap, tahap pertama proses ekstraksi karaginan dari E. cottonii dengan penggunaan KOH 14% dan tahap kedua pembuatan edible film dengan varisi konsentrasi karaginan 0,1%; 0,2%; 0,3% (b/v) dengan penambahan PEG sebagai plasticizer. Hasil FTIR menunjukkan gugus fungsi ester sulfat, ikatan glikosidik, 3,6 anhidro-d-galaktosa, gugus OH dan CH dengan bilangan gelombang berturut-turut pada rentang 1246,36-1246,9 cm-1 , 1072-1074 cm-1, 932-934 cm-1,  3370- 3382 cm-1, dan 2876-2880 cm-1. Perubahan bilangan gelombang edible film karaginan dibandingkan dengan FTIR karaginan hasil ekstraksi pada penelitian sebelumnya menunjukkan adanya interaksi antara karaginan dengan plasticizer PEG yang ditambahkan. Pengujian morfologi pada edible film pada konsentrasi karaginan 0,1% dan 0,2% dengan SEM menunjukkan permukaan yang homogen dan kontinyu, sedangkan pada konsentrasi 0,3% edible film tidak terbentuk.
Filósofos Perversos e Inúteis: o desafio de Adimanto e a comédia aristofânica
Authors: Buarque Luisa
Published: January 2020

No passo 487b do sexto livro da República, Adimanto interrompe a fala de Sócrates com uma espécie de desafio, exposto, grosso modo, da seguinte forma: os fatos mostram que os que se dedicaram à filosofia quando eram novos, e persistiram nesses estudos, tornaram-se, ou bem perversos, ou bem inúteis para a cidade; seria possível defender a filosofia de tal acusação? As duas acusações apontadas por Adimanto, inutilidade e perversidade, podem ser utilizadas, não por acaso, para resumir as características do Sócrates aristofânico de Nuvens. O presente artigo se propõe a desenvolver algumas possíveis relações entre a famosa comédia de Aristófanes e a defesa socrática que se segue ao desafio de Adimanto, que ocupa boa parte do Livro VI da República platônica.
Em defesa do cômico na contenda entre Platão e Aristófanes
Authors: Francalanci Carla
Published: January 2020

Esse artigo é uma réplica ao texto de Luisa Buarque intitulado "Filósofos Perversos e Inúteis: o desafio de Adimanto e a comédia aristofânica".
Pintar e pensar as forças: a criação em pintura e em filosofia segundo Deleuze
Authors: Barbosa Mariana de Toledo
Published: January 2020

Esse artigo é uma réplica ao texto de Cíntia Vieira intitulado "Diagrama e catástrofe: Deleuze e a produção de imagens pictóricas".
Sobre o interesse sentimental para o ingênuo em Schiller a partir de uma nota sobre Kant
Authors: Cecchinato Giorgia
Published: January 2020

O presente artigo tem como objetivo aprofundar a compreensão do conceito de “ingênuo” em Schiller. Mais precisamente pretende-se enfocar o significado e a importância da arte ingênua em relação ao papel formador da arte em geral. Para fazer isso confrontou-se o conceito de ingênuo com a complexa noção kantiana de interesse, retomada de modo indireto no escrito “Sobre a poesia ingênua e sentimental” e  apontou-se á importância da teoria dos impulsos de Fichte no desenvolvimento da estética de Schiller.
Dois cubos e um analista: figuras do objeto segundo Tania Rivera ou a questão do sujeito na arte contemporânea
Authors: Oliveira Cláudio
Published: January 2020

Esse artigo é uma réplica ao texto de Tania Rivera intitulado "O sujeito está na arte".
Religious Freedom for Indigenous Religion : A Case Study of Cemetery in Sapta Dharma
Authors: Qamariyah Farihatul
Published: January 2020

This study aims to analyze the encounter of cemetery cases related to Sapta Dharma indigenous religion and how it deals with the stateâ€™s regulation on the religious freedom in terms of expression and negotiation with the participants including the society as the victim, the local government, and the dynamic interaction among them. The framework of religious freedom by Elizabeth Shakman Hurd on Believing in Religious Freedom and the discourse of Human Rights and Religion within the debates by Rosalind. I. J. Hackett used to analyze the data. This study found that the case of cemetery in Sapta Dharma in some villages which are located in the region of Brebes Central Java underlines a significant notion on the expression of religious freedom for the Indigenous Religion. Religious freedom in the case of the needs of cemetary in Sapta Dharma also attaches the idea of majority and minority. Sapta Dharma as the minority and Islam as the majority of religion in Brebes create another standing point on the notion that minority is always in contact with such discrimination and oppression. Negotiation and mediation are two important things in putting off the caseKeywords :Religious Freedom, Sapta Dharma Cemetery, Negotiation
Manaqib In The Reception of The Banjar Community: Sanctification of Religious Text
Authors: Jannah Miftahul
Published: January 2020

Manaqib is a familiar term at moslem society in Indonesia, especially at Nahdiyyin circle, and also for Banjarese moslem society (an ethnic in South Kalimantan, Borneo). Moreover, this manaqib is already become a tradition since several decades ago, but its still flare up and lively until now. Consistency of this manaqib tradition is not release from the influence of the charismatic scholars which always spread the call to continue to traditionalize the reading of manaqib, one of which is through their works in the field of this manaqib. Among them is where the classical ulama like Siti Khadijah al-Kubra, Shaikh Samman al-Madani, Shaikh Abdul Qadir al-Jailani and the local ulama are like the Shaikh Arsyad al-Banjari, Tuan Guru Kasyful Anwar, Tuan Guru M. Zaini Gani, and many others. With qualitative-anthropological studies, this study concludes that the writing of the books by the Banjar clerics was influenced by the strength of the tarekat teachings, especially the Naqsabandiyah and Sammaniyah orders. The influence is the emergence of public trust in the sacredness of the reading of the manaqib text itself, which is believed to bring various blessings such as avoiding calamity, expanding fortune, and being aware of various other purposes. Keywords : text knowledge, manaqib, reception, Banjarese tradition
Diction And Contextualization of The Jews Verses In The Holy Qurâ€™an; Text, Translation And Commentary of Abdullah Yusuf Ali
Authors: Mardhatillah Masyithah
Published: January 2020

This paper explores how Abdullah Yusuf Ali interpreted the Jews in his tafseer book; The Holy Qurâ€™an: Text, Translation and Commentary. His interpretation becomes worth to discuss due to his profile as a Moslem officer of Great Britain which politically supported the contemporary Jews in Israel. Additionally, Yusuf Ali was the big fan of the concept of inter-faith dialogue. On the other hand, he was so proud of being a Moslem so that he wrote an English translation and commentary of the Koran in order international society can understand Islam well. This paper is going to show how Yusuf Ali put himself as a Moslem and at the same time, a Britain officer, (and also admirer) who also lived in non-Moslem milieus. The discussion will explore two parts. The first one is the diction(s) used by Yusuf Ali to interpret the Jews verses, while the second is the contemporary contextualization on his interpretation on Jews verses into nowadays life. Using library research method through primary and secondary references combined with a hermeneutical approach, this paper comes to the following conclusion. First, there found five dictions to mention the Jews at the Jews verses, which are Jews, those who followed the Jewish law, those that stand on Judaism, those who follow the spirit of Moses and those who follow the Jewish scripture. Â Second, by the diverse diction, Yusuf Ali implied that The Jews is all about the spirit and physical action of individual instead of religious institution or affiliation.