bluuebunny/crossref_metadata_2025 huggingface dataset:
Nuove miniature del Maestro del Libro d’Ore di Modena e altri frammenti tardogotici lombardi a Torino
Authors: Marzo Alessia
Published: October 2023

Seven unpublished illuminated fragments from the Museo Civico d’Arte Antica in Turin are examined and placed in the context of Lombard Late Gothic book illumination. An antiphonary with Proper and Commons of Saints decorated by the Master of the Modena Book of Hours is partially reconstructed. A miniature depicting the Imago Pietatis is traced back to one of that master’s masterpieces, the Parma Book of Hours. The well-known miniature with Saint John the Baptist is all that survives of a lost Book of Hours closely related to Michelino da Besozzo’s models, while an initial with Saint Augustine is traced back to a lost antiphonary made in Pavia, perhaps to be ascribed to the Master of Laura Bossi around 1485.
Treatment of disgust in specific emotional disorders
Authors: Rast Catherine , Woronko Sarah , Jessup Sarah C. , Olatunji Bunmi O.
Published: October 2023

Although conditioning approaches have highlighted potential characteristics of disgust in anxiety disorders, obsessive-compulsive disorder (OCD), and posttraumatic stress disorder (PTSD), these findings have yet to be translated into evidence-based treatments. Examination of the literature suggests various indicators of disgust that predict treatment outcome in these disorders. However, mechanisms remain unclear because studies examining disgust during the course of treatment are limited. Increasingly, the field has moved toward experimental investigation of strategies that reduce disgust. While cognitive reappraisal and imagery techniques appear promising, such techniques have yet to be examined as anxiety disorder treatments in large-scale randomized clinical trials. The literature also points to novel approaches to treating disgust, ranging from an inhibitory-informed approach to exposure therapy to transcranial direct current stimulation. However, the development of novel treatment approaches will require more rigorous experimental psychopathology approaches that can further elucidate processes that contribute to the etiology and/or maintenance of disorders of disgust.
Role and mechanism of PVN–sympathetic–adipose circuit in depression and insulin resistance induced by chronic stress
Authors: Wang Jing , Sun Linshan , You Jingjing , Peng Honghai , Yan Haijing , Wang Jiangong , Sun Fengjiao , Cui Minghu , Wang Sanwang , Zhang Zheng , Fan Xueli , Liu Dunjiang , Liu Cuilan , Qiu Changyun , Chen Chao , Xu Zhicheng , Chen Jinbo , Li Wei , Liu Bin
Published: October 2023

Chronic stress induces depression and insulin resistance, between which there is a bidirectional relationship. However, the mechanisms underlying this comorbidity remain unclear. White adipose tissue (WAT), innervated by sympathetic nerves, serves as a central node in the interorgan crosstalk through adipokines. Abnormal secretion of adipokines is involved in mood disorders and metabolic morbidities. We describe here a brain–sympathetic nerve–adipose circuit originating in the hypothalamic paraventricular nucleus (PVN) with a role in depression and insulin resistance induced by chronic stress. PVN neurons are labelled after inoculation of pseudorabies virus (PRV) into WAT and are activated under restraint stress. Chemogenetic manipulations suggest a role for the PVN in depression and insulin resistance. Chronic stress increases the sympathetic innervation of WAT and downregulates several antidepressant and insulin‐sensitizing adipokines, including leptin, adiponectin, Angptl4 and Sfrp5. Chronic activation of the PVN has similar effects. β‐adrenergic receptors translate sympathetic tone into an adipose response, inducing downregulation of those adipokines and depressive‐like behaviours and insulin resistance. We finally show that AP‐1 has a role in the regulation of adipokine expression under chronic stress.
RESEARCH OF DIGITAL PROTECTION TERMINALS
Authors:   Odessa National Polytechnic University, Plis Valeriy
Published: October 2023

Abstract. Due to the development of technologies, the widely used electromechanical relays in the electric power industry have been replaced by multifunctional digital relay protection terminals. For the training of students and electrical personnel of enterprises, new approaches to the creation of experimental stands are needed, which will allow us to study the features of the use of digital protection and fully reveal their capabilities. The purpose of the work is to improve the quality of the knowledge and practical skills received by students in working with digital protection blocks. To achieve the goal, a specialized laboratory stand for testing digital security terminals has been developed. The stand consists of a mathematical model of the protected object and hardware, due to which the model mode parameters are converted into physical signals and fed in real time to a real digital device. The study of the protected element is provided in the characteristic modes of its operation close to real ones by providing a connection between the relay protection terminal and the information model. The equipment used at the stand does not require significant capital investments, and therefore this approach is available to most design and training organizations. Keywords: digital protection terminal, experimental stand, analog-to-digital converter; digital-to-analog converter, mathematical model, induction motor.
Pseudo-labeling of transfer learning convolutional neural network data for human facial emotion recognition
Authors: Arsirii Olena О. , Petrosiuk Denys V.
Published: October 2023

The relevance of solving the problem of facial emotion recognition on human images in the creation of modern intelligent systems of computer vision and human-machine interaction, online learning and emotional marketing, health care and forensics, machine graphics and game intelligence is shown. Successful examples of technological solutions to the problem of facial emotion recognition using transfer learning of deep convolutional neural networks are shown. But the use of such popular datasets as DISFA, CelebA, AffectNet, for deep learning of convolutional neuralnetworks does not give good results in terms of the accuracy of emotion recognition, because almost all training sets have fundamental flaws related to errors in their creation, such as the lack of data of a certain class, imbalance of classes, subjectivity and ambiguity of labeling, insufficient amount of data for deep learning, etc. It is proposed to overcome the noted shortcomings of popular datasets for emotion recognition by adding to the training sample additional pseudo-labeled images with human emotions, on which recognition occurs with high accuracy. The aim of the research is to increase the accuracy of facial emotion recognitionon the image of a human by developing a pseudo-labeling method for transfer learning of a deep neural network. To achieve the aim, the following tasks were solved: a convolutional neural network model, previously trained on the ImageNet set using the transfer learning method, was adjusted on the RAF-DB data set to solve emotion recognition tasks; a pseudo-labeling method of the RAF−DB set data was developed for semi-supervised learning of a convolutional neural network model for the task of facial emotion recognition; the accuracy of facial emotion recognition was analyzed based on the developed convolutional neural network model and the method of pseudo-labeling of RAF-DB set data for its correction. It is shown that the use of the developed method of pseudo-labeling data and transfer learning of the MobileNet V1 convolutional neural network model allowed to increase the accuracy of facial emotion recognitionon the images of the RAF-DB dataset by 2 percent (from 76 to 78%) according to the F1 estimate. Atthe same time, taking into account the significant imbalance of the classes, for the 7 main emotions in the trainingset, we have a significant increase in the accuracy of recognizing a few representatives of such emotions as surprise (from 71 to 77%), fearful(from 64 to 69%), sad (from 72 to 76%), angrywith (from 64 to 74%), neutral(from 66 to 71%). The accuracy of recognizing the emotion of happy, which is the most common, decreased (from 91 to 86 %) Thus, it can be concluded that the use of the developed pseudo-labeling method gives good results in overcoming such shortcomings of datasets for deep learning of convolutional neural networks such as lack of data of a certain type, imbalance of classes, insufficient amount of data for deep learning, etc.
Modelingand method for assessing the efficiency of the power system
Authors: Kryvda Viktoriia I. , Suvorov Vladyslav O. , Zubak Viktor V.
Published: October 2023

The work is dedicated to addressing the issues related to assessing the efficiency of modern electrical power systems, especially as an increasing number of consumers desire to actively influence the electricity supply schedule, providing conditions to electricity producers. The research can be divided into two main segments: the development of a model for assessing the efficiency of electrical power system operation and the development of a method for analyzing the performance of the energy system, which is based on a model of changes in the quality indicators of the energy system. The proposed model takes into account properties of the energy system such as the probability of uninterrupted network operation, normalized frequency of electrical power, the volume of consumed electrical energy, and the electrical energy supplied by the transmission organization. It is expected that this model will help provide a more accurate assessment of the efficiency of energy system operation under normal operating conditions. Furthermore, a method for analyzing the efficiency of energy system operation has been developed, which is based on a model of changes in the quality indicators of the energy system. A unique featureof this method is the introduction of a new comprehensive indicator of energy system efficiency, which is determined using a convolution method of partial indicators, namely: the volume of electrical energy supply, the quality of electrical energy supply,and the efficiency of electrical energy supply. The reliability of the model was confirmed through the calculation of the daily electric supply and load schedule.
Resources for Upbringing Implementation as a State Priority
Authors:   Institute of Education Development Strategy, Selivanova Natalia Leonidovna
Published: October 2023

Introduction to the problem. Education is a state priority that requires certain resources for its realization. The aim of the article. Theoretical analysis of modern problems of upbringing, with substantiation of resources of various subjects of upbringing for full realization of upbringing as a state priority. Results of the study. Among the resources that should contribute to the implementation of education as a state priority can be attributed: the system of professional development of teachers as educators, including the principles of its organization; mentoring in the education system; the implementation of a multisubject strategy of education, the activities of the scientific school in the field of education. Conclusion. The allocation of education as a state priority is important because it creates conditions for focusing attention on the most important phenomena in this sphere, to consider them from different positions, to identify their new characteristics and educational potential.
Practice-oriented Tasks as a Means of Forming Professional Competencies of a Future Teacher at a Pedagogical University
Authors:   M. E. Evseviev Mordovian State Pedagogical University, Semenova Natalia Gennadievna , Jakunchev Mihail Aleksandrovich ,   M. E. Evseviev Mordovian State Pedagogical University, Markinov Ivan Fedorovich ,   M. E. Evseviev Mordovian State Pedagogical University
Published: October 2023

The article actualizes the formation of professional competencies of a future teacher at a pedagogical university through practice-oriented tasks. The process of practice-oriented training of a future biology teacher at a pedagogical university can be carried out with the use of various means. One of these tools is practice-oriented tasks. Under them, the authors consider a special type of teaching assignment of a teacher to students, which contains a set of requirements to perform intellectual and (or) applied educational and cognitive actions for optimal mastering of professionally-oriented content. The article presents competencies and provides examples of tasks for each of them. The purpose of the article. Presentation of practice-oriented tasks as one of the means of forming professional competencies of a future teacher at a pedagogical university. Research methodology. The priority methodological basis is a competence–based approach that determines the use of practice-oriented tasks in the aspects of “know”, “be able”, “own” in the process of preparing a future teacher. Research methods. Methods of the theoretical level – analysis of published sources on the stated topic, systematization and generalization of research material. Methods of the empirical level – pedagogical experiment, diagnostics of the state of the ability of students – future teachers to perform practice-oriented tasks, elementary mathematical calculations of the data obtained and their interpretation. Conclusion. The original tasks proposed by the authors, developed on the basis of a competence–based approach, are acceptable for professionally oriented training of students – future teachers at a pedagogical university.
Сytotoxic T lymphocyte-associated protein 4 (CTLA4) is overexpressed in a subset of prolactin- and growth hormone-secreting pituitary adenomas
Authors: Sabini Elena , Khan Amna , Caturegli Patrizio
Published: October 2023

Cytotoxic T lymphocyte-associated protein 4 (CTLA4), a negative regulator typically expressed on the surface of T lymphocytes, is targeted by immunotherapy in patients with an ever-expanding spectrum of cancers. Characterizing the expression of CTLA4 in the pituitary gland could provide additional rationale for using immune checkpoint inhibitors in pituitary adenoma patients who do not respond to conventional treatments. We assessed the expression of CTLA4 mRNA and protein in a panel of 157 human pituitary glands, 45 collected at autopsy and 112 at surgery. These specimens included 50 normal glands and 107 adenomas: 41 nonsecreting, 25 PRL-, 24 ACTH-, 11 GH-, 2 TSH-, 1 FSH-secreting, and 3 atypical. Specimens were stained for CTLA4 and adenohypophyseal hormones using RNAscope in situ hybridization, immunohistochemistry, and RNAscope Multiplex Fluorescent Assay. CTLA4 mRNA was detectable in most normal pituitary glands (48 of 50, 96%) but varied in expression, with a histological score (H-score) ranging from 0.6 to 20. The variation did not depend upon the patient’s gender and age and was not significantly affected by the archival storage time. CTLA4 expression was higher (P = 0.022) in pituitary adenomas than normal glands, with the greatest levels seen in PRL- and GH-secreting adenomas (P = 0.009 and 0.023 versus normal, respectively). Eight of 25 (32%) prolactinomas and 3 of 11 (27%) GH-adenomas had an H-score greater than 20, while no differences were seen for the other types. These novel data highlight the expression of an immune checkpoint such as CTLA4 on pituitary endocrine cells, a finding that could be exploited for therapeutical applications.
Analysis of the Content of Selected Evangelical Textbooks for Teaching Religion in Poland from the Perspective of Critical Pedagogy of Religion
Authors: Humeniuk Monika
Published: October 2023

Studies of Polish pedagogy of religion are most often situated in the area of the Roman Catholic tradition of Christianity, in its catechetical or kerygmatic current. This current aims at “education to faith” and “in faith”. The center of such a formula is the proclamation of the kerygma of salvation and the formation of the faithful who identify with their own ecclesial tradition. Adopting the formula in question, both Roman Catholic and evangelical religious education treats pedagogy as its auxiliary science providing a conceptual and methodological apparatus for the realization of goals primarily related to the local version of the theology, doctrine and teachings of a particular church. However, pedagogy of religion practiced in the kerygmatic stream is not the only stream of this sub-discipline. In addition to it, hermeneutic and critical pedagogy of religion or religious-information pedagogy, among others, are indicated. For critical pedagogy of religion, it is important to take care of the relationship between religious education and social reality. Its goals involve education for critical self-awareness and emancipatory competence, including the ability to unmask the forms of symbolic violence present in interpretations of religious texts and the social practices derived from them, as well as education for social commitment to equality and justice, opposing marginalization, exclusion, discrimination and symbolic violence in the broadest sense. The article presents content analyses of selected textbooks for teaching evangelical religion and attempts to situate the model of religious education emerging from them on the map of the indicated trends.
Cosmopolitismo realista y deuda común: Pogge, Habermas y Lafont frente a la cuestión de los impuestos europeos
Authors: Duque Silva Guillermo Andrés , Del Prado Higuera Cristina
Published: October 2023

El objetivo de este artículo es vincularel debate filosófico sobre el cosmopolitismodesarrollado hace aproximadamente unadécada entre Jürgen Habermas, Thomas Poggey Cristina Lafont con el actual procesode transformación de la Unión Europea quese genera a partir del Plan de RecuperaciónNext Generation EU. Los autores ponen endebate la legitimidad moral de los nuevosimpuestos europeos propuestos como unaforma de financiación del Fondo de Recuperacióneuropeo y cuestionan las tensionesque estas tasas generan entre soberanía estataly supraestatal. El artículo presenta un análisissobre las fuentes de obligación de dichos gravámenesen un contexto sui géneris en el quese consolida una unión fiscal, sin que existauna unidad política o una soberanía europea.Se concluye que la existencia de estos impuestossupranacionales en la UE son una pruebade la posible conciliación de perspectivas deldebate entre Pogge, Habermas y Lafont respectoa sus definiciones de un institucionalismomoral cosmopolita con justicia socialy sin un gobierno mundial. Para los autores,la clave de dicha concordancia de enfoques seencontraría en la delimitación continental dela aspiración cosmopolita que ofrece la realidadeuropea.
Posverdad y Malestar
Authors: Fortanet Fernández Joaquín
Published: October 2023

La posverdad ha pasado a formarparte de nuestro horizonte epistémico,sustituyendo los modos habituales devincularnos con la verdad y proponiendoun particular modo de relación con losindividuos que, en lugar de apelar a loshechos o a los argumentos, privilegia elvínculo sentimental. Este vínculo sentimentalcon la posverdad se asienta enun tipo de relación del individuo con lasociedad atravesado por el malestar. Es aeste malestar al que se debe apelar parareconducir los efectos negativos de laposverdad.
“La realidad tan solo se forma en la memoria”: lectura de En busca del tiempo perdido de Marcel Proust
Authors: Lozano Díaz Vicente , Romero Sánchez-Palencia Carmen
Published: October 2023

Para el escritor francés Marcel Proust,el arte en general, y más específicamentela literatura, tiene la función principal deayudarnos a incorporar el pasado a nuestrasvivencias presentes, permitiéndonosasociar lo vivido anteriormente a nuestrassensaciones y experiencias actuales,y facilitando con ello que alcancemos larealidad esencial, la realidad que va másallá de los simples hechos inmediatos yde la insoportable banalidad en la que lasexigencias y las urgencias de lo cotidianotienden a sumergirnos.
La infancia de la memoria de San Agustín o el entierro en el olvido
Authors: Vázquez-Romero José Manuel
Published: October 2023

Análisis de la representación de la infanciaen la literatura agustiniana, tranceimposible de simbolizar y para el que loimaginario sólo oferta la escena del pecadooriginal y sus secuelas: desobedienciade la desobediencia o libido y mutismoselectivo de la confesión o amnesia.
Travelling philosophers: Dewey and Russell in China
Authors: Del Castillo Ramón
Published: October 2023

The aim of this paper is a reconsiderationof John Dewey’s stay in China,an experience abroad that influencedenormously in his intellectual and humandevelopment. Our approach willbe comparative, assessing his model ofcultural dialogue through a contrast betweenhis attitudes and actions in Chinaand Bertrand Russell’s ones. We thinkthat, thanks to this thorough comparativeresearch, we make much clearer theirrespective conceptions of the role that intellectualscould play in international politicalsceneries. One hundred year afterthey arrived to and thought about China,we think that this often-unknownchapter of the history of intellectuals canbe particularly relevant for ensuing surveysof cultural studies and sociology ofknowledge.
The task of digital transformation of the scientific information environment
Authors:   Borys Grinchenko Kyiv University, Kopanieva V.O. , Kostenko L.I. ,   Vernadsky National Library of Ukraine, Novytskyi О.V. ,   Institute of Software Systems NAS of Ukraine, Reznichenko V.A. ,   Institute of Software Systems NAS of Ukraine
Published: October 2023

The article discusses the issues of building interoperable scientific and informational structures based on the use of modern information technologies. Tasks related to the creation of theoretical and methodological foundations for the development of the Ukrainian fragment of the global digital interoperable environment of scientific knowledge are defined. The importance of permanent and unambiguous identification of digital resources to ensure their availability and reusability is noted. A synergistic approach to building an integrated digital environment of publishing houses and libraries is proposed. Attention is paid to the need to create a cooperative cataloging center in Ukraine to ensure one-time entry of scientific data and their subsequent multiple and multifaceted use by all interested institutions. The need for a fundamental solution to the problem of functional interaction of the conglomerate of scientific and information structures is emphasized, which will require the development of a new generation of information systems in which the problem of interoperability will be considered one of the main ones. Ukraine’s successes in creating electronic repositories are noted.
Simulations of human hemodynamic responses to blood temperature and volume changes
Authors:   Institute of Software Systems NAS of Ukraine, Grygoryan R.D. , Degoda A.G. ,   Institute of Software Systems NAS of Ukraine, Lyudovyk T.V. ,   Institute of Software Systems NAS of Ukraine, Yurchak O.I. ,   Institute of Software Systems NAS of Ukraine
Published: October 2023

An advanced version (AV) of special software based on modified quantitative models of mechanisms that provide the overall control of human circulation is proposed. AV essentially expands the range of tasks concerning the modeling of cardiovascular physiology, in particular, the range of mechanisms controlling cardiac function, vascular hemodynamics, and total blood volume under unstable internal/ external physiochemical environments. The models are verified on data representing hemodynamic responses to certain physical tests. In the publication, two test scenarios, namely blood temperature and volume dynamic alterations, have been simulated and analyzed in detail. The user-friendly interface provides all stages of preparation and analysis of computer simulation. The PC-based simulator can also be used for educational purposes.
On the formalization of emergency action plans
Authors:   Institute of Problems of Mathematical Machines and Systems NAS of Ukraine, Yalovets A.L.
Published: October 2023

The problem of formalization of action plans to counter emergency situations is being studied. It is noted that traditional action plans are text documents that are not suitable for solving the tasks of automating the management of emergency situations. A formal description of the state space is given and the expediency of using the state space graph to represent electronic action plans is substantiated. Based on the analysis of the internal structure of the process of countering an abstract emergency, a set of functional groups and their constituent operations are identified, using which an arbitrary action plan can be built. The identification of a set of types of parameters is carried out, through which the formalization of operations is provided. The advantages of using the proposed formalization of action plans for automating the processes of emergency response management are given.
Penggunaan Media Interaktif sebagai Bahan Literasi Digital Era 21 untuk Pembelajaran di Sekolah Dasar
Authors: Listyawan Ersha Amalia , Karlina Iin , Ayushandra Vania
Published: October 2023

With technology from age to age increasingly sophisticated in the needs of all of us. Technological progress is accelerating, and with digital literacy through interpainful media it is easier for students to achieve excellence and educational goals. Education in the 21st era, students are more likely to close or adapt to learning through the media because it portrays material through digital literacy with interactive media to achieve the purpose of learning. The methods used in this study use the analysis of content from various journals by describing them. With this study, researchers have excavated digital literations regarding interactive media for elementary school children. The study also brought positive values with informative, inspiring and useful value. As a result of this study, it presents interactive media as text, animation, or comics, existing media from youtube, powerpoint given by teachers or getting information from the Internet, kahoot, edmodo, Google classroom, Google meet, quiziz, e-book or something else and can be used as a digital literacy for students or readers to understand.
Entre altos e baixos
Authors: Scorsolini-Comin Fabio , Grizólio Talita Cristina , Santos Manoel Antônio dos
Published: October 2023

Na convivência de longa duração, os momentos considerados signifi cativos pelos casais são importantes referências para se entender a satisfação com os modos de se relacionar a dois. O objetivo deste estudo foi compreender como casais engajados em relacionamentos de longa duração percebem os “melhores” e “piores” momentos vivenciados na conjugalidade. Entrevistas semiestruturadas foram conduzidas com 25 casais heterossexuais, que estavam juntos, em média, há 39,5 anos. As entrevistas transcritas foram submetidas à análise temático-refl exiva. A experiência da parentalidade e a convivência familiar foram identificadas como os melhores momentos e, como piores experiências, o enfrentamento do adoecimento ou morte de um membro familiar e dificuldades financeiras. Conclui-se que, para os casais entrevistados, convivência familiar e cuidados parentais são percebidos como determinantes da satisfação conjugal. As relações conjugais são classifi cadas de forma dicotômica, como boas ou ruins, a partir de fatos pontuais que eliciam satisfação ou insatisfação com o relacionamento, sem considerar que o vínculo amoroso é dinâmico e, portanto, sensível a melhores e piores momentos.
Desafios familiares durante a pandemia e o fortalecimento de vínculos na infância
Authors: Corrêa Medina Alice Maria , Ribeiro Marina , Kyrillos Isabela
Published: October 2023

Durante o período de pandemia da COVID-19, um dos maiores desafios, da sociedade, está relacionado aos impactos relacionais domiciliares e, neste sentido, a proposição de atividades lúdicas, pode ser uma estratégia promissora para a criação de vínculos domiciliares. O objetivo do estudo, entre outros, foi de estimular a produção infantil junto aos familiares. Participaram da pesquisa 14 crianças, de duas turmas de Educação Infantil, de uma escola pública de Brasília – DF. Conclui-se, que o engajamento, das famílias, durante as atividades infantis lúdicas são fundamentais para a criação e efetivação de relações familiares mais afetivas, podendo ser considerada como uma atividade atemporal para a criação e fortalecimento de vínculos familiares.
Study of the image characteristics of school uniforms in the educational environment
Authors: Ruban Anna , Falko Ludmila , Klochko Inna
Published: October 2023

The article is devoted to the study of the school uniform image characteristics. The relevance of the work is related to the discussion that has resumed in Russian society in connection with the possibility of introducing a standard for school uniforms by 2024. This study analyzes the attitude towards the problem of students, parents and employees of educational institutions. The sociological method (survey in the form of a questionnaire) was used in the work. The respondents were residents of the Primorsky Territory, 452 people took part in the survey.
It has been established that students deny the need for uniform, while parents and teachers support the idea of a school uniform in education institutions.
Positive and negative image characteristics of a school suit are revealed. Respondents consider the absence of a problem in the everyday choice of clothes and the maintenance of school discipline as positive characteristics of wearing a uniform. The negative characteristics of the school suit, according to students, are the lack of opportunities for self-expression and individuality, while most parents and teachers believe that there are no negative image characteristics of the school uniform.
In terms of visual image characteristics, students would prefer to wear a preppy school uniform, parents and teachers would like to see a business style school uniform (classic with casual elements).
When choosing a color solution for school uniforms, students would like to wear black clothes, arguing that black is a versatile and elegant color. Parents and teachers would prefer to see school uniforms predominantly blue.
COLORECTAL CANCER: HISTOPATHOLOGICAL PROFILE AND PREVALENCE OF DNA REPAIR SYSTEM DEFICIENCY IN PATIENTS SUBMITTED TO SURGICAL TREATMENT IN A UNIVERSITY HOSPITAL
Authors: Oliveira Julia Werner de , Moraes Raquel Aguirra de , Mehanna Samya Hamad , Linhares Julia Costa
Published: October 2023

ABSTRACT BACKGROUND: Part of colorectal cancer cases occurs due to modifications in the DNA mismatch repair system, which are responsible for microsatellite instability. This alteration results in an unconventional phenotypic pattern of colorectal cancer. AIMS: To describe the epidemiological, histopathological and molecular profiles of patients with colorectal cancer who underwent surgical treatment in a reference hospital. METHODS: This is a cross-sectional, retrospective study with a quantitative approach, that included a review of patients’ medical records who underwent oncological surgery for colorectal cancer. RESULTS: A total of 122 colorectal cancer cases were identified, with microsatellite instability detected in 8.2% of the sample. The gender distribution was similar, with 52.46% males, and the weighted average age was 63 years (standard deviation±11.65). However, in the microsatellite instability group, the predominant age was below 60 years. Regarding the histological type, adenocarcinoma not otherwise specified accounted for 80.33% of the cases, being the most prevalent in both groups, with the mucinous type being more frequent among the instability cases. The pT3 pathological staging (46.72%) was the most predominant. The topography was more prevalent on the left (60.66%), but there was a significant difference when compared to the group with microsatellite instability, in which 80% of the neoplasms were located on the right (p=0.006). CONCLUSIONS: Differences in age and neoplastic topography found in microsatellite instability samples highlight the distinctive presentation pattern of the disease. Recognizing these characteristics is essential for developing prevention strategies, in addition to early and accurate diagnosis of colorectal cancer.
In vitro inhibitory activity of spice-derived essential oils for multi-drug resistant Aspergillus fumigatus recovered from poultry feed
Authors: Naeem Alishba , Ashraf Muhammad Adnan , Anjum Aftab Ahmad , Sheikh Ali Ahmad , Ali Tehreem , Manzoor Rabia
Published: October 2023

ABSTRACT Aspergillus fumigatus is a respiratory pathogen, which has the potential to cause brooder pneumonia in poultry chicks and aspergillosis in birds and farmers. Frequent and irrational use of antifungals has led to the development of resistance in the fungal species. The present study aimed to evaluate the antifungal activity of essential oils (EOs) from four different spices against multi-drug resistant (MDR) A. fumigatus isolated from 40 poultry feed samples. Twenty fungal isolates were identified to be A. fumigatus based on the macroscopic and microscopic characteristics, which were confirmed by targeting and amplifying the species-specific rodA gene (313 bp). Five (5/20) isolates were found to be MDR by the disk diffusion method. EOs were tested as an alternative strategy for 5 MDR isolates of A. fumigatus. Clove EO provided better activity by 6 log10 reduction for 30-90 min exposure as compared to other EOs, therefore, shortlisted for well-diffusion and minimum inhibitory concentration (MIC) method. Clove EO provided promising results as compared to fluconazole, amphotericin B, ketoconazole, nystatin and voriconazole as its mean ZOI (39.6 ± 6.34) were better than all other commercial antifungals (p< 0.001). Mean MIC was reported to be 0.195 ± 0.11 µl/ml. Safety testing of the EO produced 74-82% cell viability for the range of 0.390 - 0.097 µl/ml as compared to DMSO. Findings of the present study highlight that clove EO can be source of a good therapeutic agent for infections of MDR isolates of A. fumigatus.
Autocompaixão em Estudantes Universitários: Revisão Integrativa da Literatura
Authors: Pereira Mara Dantas , Silva Joilson Pereira da
Published: October 2023

Resumo O objetivo deste estudo foi revisar a produção científica, em busca de reunir evidências empíricas sobre autocompaixão em estudantes universitários. A revisão integrativa abrangeu artigos publicados no período de 2009 a 2021, indexados nas bases PsycINFO, PubMed, Scopus e Web of Science, nos idiomas português, inglês ou espanhol. Um total de 183 estudos foram encontrados e, após as etapas de triagem, elegibilidade e seleção, foram incluídos 9 artigos, seguindo as diretrizes propostas pelo PRISMA. A análise dos resultados foi categorizada a partir de dois tópicos: (i) intervenções baseadas em autocompaixão para acadêmicos e (ii) a autocompaixão como fator psicológico protetivo à saúde mental de estudantes do ensino superior. Os resultados mostraram que a autocompaixão é considerada um importante fator protetivo para o funcionamento psicológico positivo e ao desenvolvimento de características que reflitam dimensões positivas da saúde mental e do desempenho acadêmico em estudantes universitários.
Resisting Racism: Life and Career Narratives of Black Undergraduate Students
Authors: Ancillotti Caio Gracco Lima , Silva Priscilla de Oliveira Martins da
Published: October 2023

Abstract The present study aimed to identify how racism appears in the lives and careers of Black undergraduate students in a Brazilian Public Higher Education Institution. For this purpose, this study conducted 27 narrative interviews with self-declared black undergraduates, which were analyzed using the technique of thematic Biography and Narrative Analysis. The results indicated that despite the existence of distinctions between the undergraduates’ trajectories, usually caused by socioeconomic differences, racism similarly impacts their lives and careers, presenting itself in three frequent themes, named by the researchers as: “Experiences with Racism”, “Awareness of Racism”, and “Management of Racism”. It was found that, although there are distinctions between experiences, motivated especially by socioeconomic origin and available opportunities, all participants manage the effects of racism, individually and collectively, leading them to changes in career prospects, to enable the construction of viable professional trajectories to achieve their ambitions.
Impacto Psicossocial da Pandemia de COVID-19 na Saúde Mental de Pessoas Transexuais e Travestis: Revisão Integrativa
Authors: Santos Manoel Antônio dos , Alexandre Vinicius , Risk Eduardo Name , Oliveira Wanderlei Abadio de , Peres Rodrigo Sanches , Oliveira-Cardoso Érika Arantes de
Published: October 2023

Resumo Este estudo objetivou identificar, analisar e integrar resultados de estudos que examinaram o impacto da pandemia de COVID-19 na saúde mental de pessoas transexuais e travestis. Foi realizada uma revisão integrativa da literatura, em conformidade com as diretrizes PRISMA. Conduziu-se uma busca sistemática dos estudos primários publicados em três bases de dados: PubMed/MEDLINE, LILACS e PsycINFO. Foram incluídos oito estudos que atenderam aos critérios de inclusão. A análise temática do material gerou seis categorias temáticas. Os estudos analisados apontaram que a situação de vulnerabilidade social ao qual as pessoas trans encontram-se submetidas no cotidiano foi ampliada durante a pandemia. A necessidade do distanciamento físico resultou no aumento de sintomas de ansiedade e depressão, agravamento das condições econômicas, dificuldades para acessar procedimentos e medicamentos que compõem o processo de afirmação de gênero, além de exacerbar conflitos familiares e manifestações de transfobia. Há necessidade de implementar políticas públicas e uma rede de proteção social para diminuir a vulnerabilidade e sofrimento psicossocial de pessoas trans.
Psicologia Positiva e Transtornos Relacionados a Substâncias Psicoativas: Uma Revisão Integrativa
Authors: Santos Kayê Reichow dos , Reppold Caroline Tozzi , Neves Luísa Müller , Terra Mauro Barbosa
Published: October 2023

Resumo Este estudo busca identificar e analisar os estudos que associam a Psicologia Positiva e seus construtos com os transtornos relacionados ao uso de substâncias psicoativas. Foi feita uma revisão integrativa sobre o tema. De 64 resultados encontrados, 13 artigos foram selecionados para descrição e análise. Identificou-se baixa produção científica sobre o tema, ainda que esteja em expansão. Apenas sete estudos tinham como objetivo principal a relação entre a Psicologia Positiva e o uso de substâncias psicoativas, sendo apenas dois experimentais. Evidenciou-se também a concentração de publicações nos EUA e a falta de estudos brasileiros. Os construtos da Psicologia Positiva mais abordados são a felicidade e a espiritualidade, estando associados a um menor uso de substâncias psicoativas. Fica demonstrado o potencial desse campo de estudo para a prevenção e tratamento desses transtornos, sugerindo-se o aumento da produção cientifica.
Análise da evolução espacial e fatores associados à morbimortalidade por Covid-19 nas regiões geográficas do Brasil: um estudo ecológico
Authors: Maciel Jacques Antonio Cavalcante , Pará Jefferson Wyllian de Sousa , Monteiro Ana Kamila Araújo , Araújo Francisca Elane dos Santos , Siqueira Jordânia Chaves de , Sousa Joelton Rosendo , Castro-Silva Igor Iuco
Published: October 2023

Resumo Objetivo Este estudo analisou a evolução do padrão de distribuição espacial dos coeficientes de morbimortalidade por Covid-19 e fatores associados nas Regiões Intermediárias de Articulação Urbana do Brasil. Métodos Estudo ecológico com variáveis de bancos secundários, com dados de incidência e mortalidade por Covid-19 acumulados no intervalo de três meses, o que corresponde ao aumento das medidas de flexibilização do isolamento social. As variáveis independentes representaram fatores socioeconômicos. Foram realizadas análise de dependência espacial, regressão clássica e espacial. Resultados Houve um aumento da morbimortalidade por Covid-19 entre os dois períodos analisados. Foi encontrada uma autocorrelação positiva com formação de cluster em áreas de maior incidência de Covid-19 e com maior significância em Regiões Intermediárias de Articulação Urbana na região Norte do Brasil, com agrupamentos maiores em relação à mortalidade após a flexibilização das medidas de isolamento. A ocorrência da morbimortalidade apresentou associação significativa com variáveis étnicas com maiores coeficientes de determinação na região Norte. Conclusão Determinantes sociais demonstraram um comportamento preditivo no aumento da autocorrelação positiva para a mortalidade por Covid-19 durante os períodos observados, com aumento da morbimortalidade na região Norte após a flexibilização do isolamento social.
"Sob o governo de gorilas": a perseguição aos funcionários homossexuais do Ministério das Relações Exteriores em tempos de AI-5
Authors: Motta Murilo
Published: October 2023

Resumo Durante a ditadura hetero-militar brasileira, discursos que relacionavam as homossexualidades à subversão justificaram a remoção de pessoas LGBTQIA+ dos espaços públicos. Este artigo trata da repressão de funcionários homossexuais do Ministério das Relações Exteriores (MRE) após a implementação do Ato Institucional n. 5 (AI-5). São analisados documentos referentes aos casos da Comissão de Investigações Sumárias de 1969 (CIS 69) e da Comissão de Anistia vinculada ao MRE de 1986. Os resultados relativizam o corporativismo do MRE, ressaltando a matriz heterossexual da instituição.
Desejo e acusação: a "novinha" e a sexualidade feminina como fonte de tensão
Authors: Fernandes Camila
Published: October 2023

Resumo O artigo analisa a figura da "novinha" enquanto categoria articuladora de idade e comportamento, na interface com outros marcadores sociais da diferença, tais como gênero, território, raça e sexualidade. A partir de etnografia realizada em duas favelas do Rio de Janeiro, discuto as tensões que pesam sobre as "novinhas": o uso das roupas curtas, a "afronta", o "medo de engravidar", as acusações sobre usurpação de relações afetivas e a provocação de homens mais velhos. Ao final, apresento de que maneira a relação entre performance e enquadramento evidencia um campo de tensões mais amplo relativo à sexualidade feminina que atualiza um imaginário racializado e colonial acerca de meninas negras e moradoras de favela.
Bisexuality and ambiguity: metaphoric relations and metonymic processes in discursive productions on bisexuality
Authors: Calmon Diego
Published: October 2023

Abstract The absence of research on bisexuality in the twentieth century and concerns regarding the AIDS epidemic enabled the construction of speculative narratives on the bisexual population, which is commonly described as an ambiguous category. Analyzing bisexuality through an anthropological lens, this article examines the symbolic complexes that produce bisexuality as an ambiguous category, relating it to the discursive production of fictions of contagion, which are essentially metonymic.
Ações corretivas do Estado sobre os defeitos estruturais de controle do capital: uma análise na perspectiva de István Mészáros
Authors: Santos Milena da Silva
Published: October 2023

Resumo Este texto tem como objetivo evidenciar as ações corretivas do Estado sobre os defeitos estruturais de controle do capital, com base nas formulações teóricas de István Mészáros. É fruto de uma investigação realizada a partir de um enfoque materialista-histórico e procedimento metodológico de pesquisa bibliográfica. Analisamos que os defeitos estruturais de controle do capital estão relacionados às ausências de unidade na base material da reprodução social entre produção, controle, consumo e circulação. Porém, para a manutenção da reprodução do capital, o sistema demanda um comando político que se apresenta através do Estado. Verificamos que este exerce a função de remediar os defeitos estruturais de controle do sistema, através de ações corretivas. Ressaltamos que a constituição da relação capital impede a resolução dos defeitos e que estes só podem ser eliminados com a superação do capital.
Núcleo de apoio pedagógico especializado: espaço de atuação do Serviço Social
Authors: Araújo Luciene
Published: October 2023

Resumo Objetivamos conhecer a atuação de assistentes sociais na educação especial, tendo como espaço socio-ocupacional o Núcleo de Apoio Pedagógico Especializado professora Maria Marcelina da Silva localizado na cidade de Russas, no estado do Ceará. O núcleo é uma instituição composta por equipe multiprofissional voltada para atender estudantes com dificuldade de aprendizagem. Dito isso, partimos da nossa experiência enquanto assistente social desta instituição desde setembro de 2021 até os dias atuais. Ademais, utilizamos o arcabouço teórico referente à educação especial no Brasil e no Ceará, bem como as contribuições teóricas, metodológicas, éticas e políticas referentes à atuação de assistentes sociais na educação. Finalizamos, afirmando que o Serviço Social atua em defesa da garantia do direito à educação gratuita, pública, de qualidade e inclusiva realizando acolhimento social, orientação para as famílias e articulação da rede intersetorial.
Acumulação como violência, violência como acumulação: o Estado e o capitalismo dependente
Authors: Campos Gustavo de Aguiar , Oliveira Isabel Fernandes de
Published: October 2023

Resumo Este ensaio teórico tem como objetivo discutir o recurso à violência estatal no capitalismo dependente. Discute-se como a violência é necessária para a autorreprodução do capital e para a manutenção da contradição capital-trabalho. Tal necessidade se coloca em decorrência das debilidades estruturais impostas pela relação imperialismo e dependência, como a transferência de valor, a superexploração da força de trabalho, o agravamento das expressões da “questão social”, o racismo e a subsoberania. Para tanto, o artigo tem dois pontos centrais: a relação imperialismo e dependência e a amálgama entre Estado dependente e violência. Com a discussão, apreende-se que a manutenção do Estado dependente faz uso da violência para: a) superexploração da força de trabalho; b) realizar e/ou apoiar as expropriações; c) garantir as condições políticas de reprodução do capital; d) controlar as possibilidades de revolta e revolução, realizando a mediação da luta de classes através da violência.
Racismo e proibicionismo: Um retorno ao pensamento social do negro no Brasil
Authors: Araújo Evelly
Published: October 2023

Resumo Objetiva-se apreender os principais elementos da formação socio-histórica brasileira que sustentam e reforçam o racismo como estrutura indispensável para a consolidação do proibicionismo às drogas e sua matriz contemporânea estadunidense, com base em teóricos que contribuíram para o pensamento social do negro no Brasil. Há uma problemática fundamental na relação entre proibição e racismo: a eminência do trabalho livre, pós-abolição e a forma de integração do negro na constituição econômico-social do capitalismo dependente, desde o período de transição. Ou seja, há um atravessamento histórico entre a divisão racial do trabalho, a exclusão delegada à população negra na ordem social do capitalismo brasileiro, e a sustentação do racismo científico, da medicina social eugenista junto ao higienismo mental da psiquiatria e do Direito Penal, como marco embrionário da proibição. O resultado disso é a criminalização da pobreza moldada pelo racismo, e a reatualização da imagem do usuário de drogas como degenerado moral e criminoso.