bluuebunny/crossref_metadata_2025 huggingface dataset:
Human Mesenchymal Stromal Cells: Identifying Assays to Predict Potency for Therapeutic Selection
Authors: Deskins Desirae L. , Bastakoty Dikshya , Saraswati Sarika , Shinar Andrew , Holt Ginger E. , Young Pampee P.
Published: January 2013

Multipotent mesenchymal stromal cells (MSCs) have the potential to repair and regenerate damaged tissues, making them attractive candidates for cell-based therapies. To maximize efficacy of MSCs, prediction of their therapeutic abilities must be made so that only the best cells will be used. Our goal was to identify feasible and reproducible in vitro assays to predict MSC potency. We generated cell lines from 10 normal human bone marrow samples and used the International Society for Cellular Therapy's minimal criteria to define them as MSCs: plastic adherence, appropriate surface marker expression, and trilineage differentiation. Each MSC line was further characterized by its growth, proliferation, and viability as determined by cell count, bromodeoxyuridine incorporation, and cellular ATP levels, respectively. To determine whether these tests reliably predict the therapeutic aptitude of the MSCs, several lines were implanted in vivo to examine their capacity to engraft and form granulation tissue in a well-established murine wound model using polyvinyl alcohol sponges. Long-term engraftment of MSCs in the sponges was quantified through the presence of the human-specific Alu gene in sponge sections. Sections were also stained for proliferating cells, vascularity, and granulation tissue formation to determine successful engraftment and repair. We found that high performance in a combination of the in vitro tests accurately predicted which lines functioned well in vivo. These findings suggest that reliable and reproducible in vitro assays may be used to measure the functional potential of MSCs for therapeutic use.
Prostate Cancer Treatment on the Basis of an Individual Risk Profile; Can we Reduce Overtreatment?
Authors: Eelco R.P. Collette  , Monique J. Roobol
Published: January 2013

Prostate cancer (PCa) is the most prevalent cancer in male population with an incidence rate of 93 per 100.000 men in Europe and is the sixth leading cause of cancer related deaths in men. In the last two decades the incidence of PCa has increased, which is related to widespread prostate-specific antigen (PSA) based screening and increased life expectancy. Mortality rates of prostate cancer have been reduced due to improvement in treatment and/or the widespread screening activities. Major down sides of screening are the potential risks of overdiagnosis and subsequent overtreatment. Approximately 50% of PCa cases detected through screening are potentially overdiagnosed and hence do not require active treatment. However, in clinical practice men with a potentially non-life-threatening cancer (indolent cancer) are often treated actively resulting in unnecessary suffering from serious side effects coinciding with active treatment. The way out of this dilemma is two-fold. First, the actual diagnosis could be delayed or even avoided and second, radical treatment could be delayed or avoided for patients with low-risk PCa. To better predict the presence of a (potentially indolent) prostate cancer nomograms have been developed. These multivariate prediction tools can be of aid in avoiding unnecessary biopsies reducing overdiagnosis, or identifying potentially indolent prostate cancer after diagnosis and hence adapt the treatment strategy. In this expert opinion we discuss the available tools and their performance in reducing the unwanted side effects of prostate cancer screening. In addition, we provide an overview of strategies concerning optimisation and individualisation of treatment, to reduce overtreatment of prostate cancer.
Correlations between the Mammographic Features of Triple-Negative and Triple-Positive Breast Cancer
Authors: Cui Chunxiao  , Lin Qing  , Liu Xiaoqing  , Zhao Jiping
Published: January 2013

Purpose:To comparative analyze the mammographic findings and clinical characteristics of triple negative breast cancer (estrogen receptor [ER] negative, progesterone receptor [PR] negative, and human epidermal growth factor receptor2 [HER2] negative) and triple positive breast cancer (ER positive, PR positive, and HER2 positive).
Materials and Methods: The immunohistochemistry results of 174 cases of TNBC and 97 cases of TPBC were reviewed. All of the patients had undergone mammography. Retrospectively evaluate the visibility, morphology, distribution and size of the lesions (masses and calcifications) and breast density on mammography of TNBC, and to compare with those of TPBC. The age onset and pathologic type were also reviewed.
Results: TNBC more frequently presented as merely a mass (95/150[63.3%]) than TPBC (34/88 [38.6%]) (P<0.01). TNBC were less frequently associated with microcalcifications (33/150[22%]) than were TPBC (39/88 [44.3%]) (P<0.01). Mammographic density and lesion visibility were similar between the two immunophenotypes. The mean age of TNBC (52[32~87]) was older than that of TPBC (48[26~68]) (P=0.002). Infiltrating ductal carcinoma was the main pathologic type of both groups. Basal-like breast cancer accounted for 47.7% (83/174) of TNBC but didnt express in TPBC (0/97).
Conclusion: The mammographic features of TNBC that lesions showed merely a mass with obscured margins, and less associated with microcalcifications might be useful to diagnose triple negative breast cancer.
Overwhelming Paroxysmal Nocturnal Haemoglobinuria in a Patient with Low-Risk Myelodysplastic Syndrome and Long-Term Anticoagulation for Sick Sinus Syndrome
Authors: Vincent Éthier  , Marie-Claude Foley  , Sarah Higgins  , Régen Drouin  , Julie Abel  , Rabia Temmar  , Rami Kotb  , Hans Knecht
Published: January 2013

Paroxysmal nocturnal haemoglobinuria (PNH) is a rare form of acquired Coombs negative haemolytic anaemia manifested by the clinical triad of intravascular haemolysis, venous thrombosis and cytopenia. At the molecular level PNH is defined by a clonal expansion of hematopoietic stem cells having undergone somatic mutation of the X-chromosome gene PIG-A. Here we report the case of an 80-year old female patient known for sick sinus syndrome for more than 30 years and low-risk myelodysplastic syndrome (MDS) with uneventful course over the past two years. In good health she underwent her fifth lead replacement under short-term reversal of anticoagulation. Two weeks later she presented at the emergency room for epigastric pain, vomiting and fever. Work up revealed extensive right jugular vein thrombosis, Coombs-negative haemolytic anaemia and acute renal failure. Paroxysmal nocturnal haemoglobinuria was suspected and confirmed by flow cytometric FLAER-assay, which detects clonal deficiency of glycosyl-phosphatidyl-inositol linked surface proteins on monocytes and granulocytes. Thus, search of a PNH clone with FLAER was reliable in the presence of RBC-transfusions and ongoing intravascular haemolysis. Though stabilization of haemolysis was achieved, renal failure progressed and the patient deceased suddenly at the 11th day of hospitalization. Short-term reversal of anticoagulation and functionless retained pacing leads may have catalyzed thrombosis in our MDS patient with a large glycosyl-phosphatidyl-inositol (GPI) deficient clone. In MDS patients under long-term anticoagulation any short-term reversal of anticoagulation for surgical procedures should be preceded by FLAER analysis to uncover an emerging GPI-deficient clone since recent developments in the treatment of this condition allow prevention of intravascular haemolysis and thrombosis by halting the complement cascade at the C5 level with targeted immunotherapy.
The Efficacy of Using the Tissue Fragments Present in Cervical Scrapes for the Histologic Diagnosis of Cervical Neoplasia
Authors: Mathilde E. Boon  , Pio Zeppa
Published: January 2013

Cervical scrapes to diagnose cervical neoplasia, collected by the clinician with brushes, are sent to the Leiden Cytology and Pathology Laboratory (LCPL) in vials containing BoonFix, a noncross-linking coagulant fixative. Because the residual material left in the vials contains tissue fragments with important diagnostic information, we stored the residual material in our archives. The tissue fragments can be mummified and archived in commercially available histology cassettes. We can produce paraffin sections thereof. Immunostaining is beautiful on serial paraffin sections cut from these blocks. We experienced that it is important to leave the brush in the vial such that all tissue fragments can be used for histologic diagnosis. In order to optimize the system, tissue fragments left in the endocervical part of the brush are removed in a paint shaker. We illustrate this principle of recovering mummified tissue fragments in a false negative case with cytology containing many undiagnosable collapsed tissue fragments. This case shows clearly the efficacy of using the tissue fragments present in cervical scrapes for the histologic diagnosis of cervical neoplasia.
Soi disant sujet, ou « La fiction suit son cours »
Authors: Michaud Ginette
Published: January 2013

Dans Double Oubli de l’Orang-Outang (Galilée, 2010), Hélène Cixous raconte ses « retrouvailles » avec le manuscrit de son premier livre, Prénom de Dieu, paru en 1967. Dans une sorte de Bildungsroman en abyme où l’archive de l’oeuvre se trouve en quelque sorte réincorporée dans la fiction littéraire, la narratrice de ce récit réfléchit sur la figure de l’auteur qu’elle « fut » : « Quand ai-je commencé à être moi-même mon auteur ? Ai-je écrit les nouvelles du Prénom de Dieu en tant que pleinement responsable de mes actes ? Étais-je plongée dans un état d’hypnose ? […] Suis-je une fiction ? », se demande-t-elle en se confrontant non sans inquiétude à cette question qui lui « cause des dommages irréparables ». Reprenant la question de Foucault au sujet de la fonction auteur, ce texte interroge à son tour ce qu’il en est de la question du « soi disant sujet » lorsque, en déconstruction et en psychanalyse, celui-ci, oscillant entre qui et quoi, est non seulement dédoublé mais irréductiblement divisé entre ses semblants, vrais et faux, pseudonymes et autres spectres, dissociation qui ébranle toutes les assises (forme, substance, ipséité, causalité, chronologie) donnant consistance à l’identité. Plusieurs aspects – notamment ceux de la mémoire, du nom, du faux, de la « réalité », fictive et pourtant vraie – sont également au foyer des questions pensées par ce récit d’Hélène Cixous.
Le roman en perspective curieuse
Authors: Randall Marilyn
Published: January 2013

« Trou de mémoire sera, lui aussi, une anamorphose, une série d’effets de perspective et de trompe-l’oeil. » Ce jugement sur le roman, émis par René Dionne en 1968, est suivi de près par un autre : « Trou de mémoire ne réussit qu’à dissimuler bien imparfaitement, malgré le fin drapé de sa prose et de sa composition en trompe-l’oeil, l’individu Hubert Aquin **. » Ces deux constats — que l’anamorphose gouverne la forme du roman et que la figure de l’auteur y est cachée — n’ont cessé de dominer la critique de Trou de mémoire depuis sa publication. Si l’anamorphose semble tournée résolument vers l’activité lectorale, posant un dilemme qui exige une multiplicité de perspectives, voire une schizophrénie perceptuelle, elle révèle en même temps la présence d’une intention auctoriale à l’origine du sens. L’anamorphose pose une énigme herméneutique située aux antipodes de la logique de « l’oeuvre ouverte » : qui ne déchiffre pas la « figure cachée » a raté sa lecture ; qui la déchiffre a perdu sa liberté interprétative ; l’auteur lui impose le sens final qu’il est seul à déterminer. L’anamorphose figure l’inscription à même l’oeuvre de la présence de l’auteur et de son intention. Que l’anamorphose comme clé de lecture de Trou de mémoire n’ait pas abouti à ouvrir tous les mystères de l’oeuvre ne fait que renforcer sa signification fondamentale, celle de révéler derrière les perspectives multiples du texte la présence singulière de son auteur.
Politiques de Saturne
Authors: Hamel Jean-François
Published: January 2013

Cet article propose une lecture de la figure d’Hamlet chez Jacques Ferron et Hubert Aquin, depuis leurs contributions à la revue Parti pris, au mitan des années 1960, jusqu’aux textes crépusculaires que sont Du fond de mon arrière-cuisine et Neige noire. En s’appropriant le personnage mythique de la tragédie de Shakespeare, Ferron et Aquin placent leur engagement sous le signe de Saturne, divinité traditionnellement associée à la mélancolie. Chez l’un et l’autre, les apparitions du prince illustrent en effet une politique de la littérature fortement ambivalente, qui entrelace le mort et le vif, la folie et la raison, la puissance et l’impuissance, comme si l’autorité de l’écrivain provenait de sa capacité à s’excepter de toute souveraineté afin de porter au langage l’expérience blessée de son absence.
Acute Radiation Esophagitis Caused by High-Dose Involved Field Radiotherapy with Concurrent Cisplatin and Vinorelbine for Stage III Non-small Cell Lung Cancer
Authors: Kuroda Yuuki , Sekine Ikuo , Sumi Minako , Sekii Shuhei , Takahashi Kana , Inaba Koji , Horinouchi Hidehito , Nokihara Hiroshi , Yamamoto Noboru , Kubota Kaoru , Murakami Naoya , Morota Madoka , Mayahara Hiroshi , Ito Yoshinori , Tamura Tomohide , Nemoto Kenji , Itami Jun
Published: January 2013

Purpose of this study is to obtain dose-volume histogram (DVH) predictors and threshold values for radiation esophagitis caused by high-dose involved field radiotherapy (IFRT) with concurrent chemotherapy in patients with stage III non-small cell lung cancer (NSCLC). Thirty-two patients treated by 66 Gy/33 Fr, 72 Gy/36 Fr, and 78 Gy/39 Fr thoracic radiotherapy without elective nodal irradiation plus concurrent cisplatin and vinorelvine were reviewed. Acute radiation esophagitis was evaluated according to common terminology criteria for adverse events version 4.0, and correlations between grade 2 or worse radiation esophagitis and DVH parameters were investigated. Grade 0–1, 2, 3, and 4–5 of radiation esophagitis were seen in 11 (34.4%), 20 (62.5%), 1 (3.1%), and 0 (0%) of the patients, respectively. Multivariate analysis revealed that whole esophagus V35 is a predictor of radiation esophagitis (OR = 0.74 [95%CI; 0.60–0.91], p = 0.006). There is a significant difference (38.4% vs. 89.4%, p = 0.027) in the cumulative rates of acute esophagitis according to V35 values of more than 20% versus less. As compared with other factors concerning patient and tumor and treatment factors, V35 < 20% of the esophagus was an independent predictor (HR = 0.29 [95%CI; 0.09–0.85], p = 0.025). In conclusion, whole esophagus V35 < 20% is proposed in high-dose IFRT with concurrent chemotherapy for stage III NSCLC patients.
Stereotactic Body Radiation Therapy for Curative Treatment of Adrenal Metastases
Authors: Rudra Sonali , Malik Renuka , Ranck Mark C. , Farrey Karl , Golden Daniel W. , Hasselle Michael D. , Weichselbaum Ralph R. , Salama Joseph K.
Published: January 2013

The detection of oligometastatic adrenal metastases is increasing and there are limited data supporting the use of curative intent stereotactic body radiation therapy (SBRT) to treat patients with limited metastatic disease with adrenal involvement. Therefore, we utilized a prospectively maintained database of consecutive patients treated with SBRT for limited metastatic disease (<5 sites) to identify patients with adrenal metastases. Patients were either treated on a three-fraction dose escalation protocol or a ten fraction off-protocol regimen. Outcomes including treated-metastasis control (TMC), distant control (DC), and overall survival (OS) were calculated by the Kaplan-Meier method. Ten patients with 13 adrenal metastases were identified for this case series. The median follow-up was 14.9 months. No patient experienced grade 3 toxicity. The most common grade 1–2 acute toxicities were fatigue (80%) and GI toxicity (40%). One patient experienced late grade 2 adrenal insufficiency. Overall, the 1-year TMC rate was 73%, DC was 30%, and OS was 90%. Three treated adrenal metastases progressed, all receiving the lowest BED10 (43.2 Gy), corresponding to 24 Gy in 3 fractions. After treatment of adrenal metastases with SBRT, the median time to salvage chemotherapy was 5.3 months (range 1.0–38.8 months) and 1-year freedom from salvage chemotherapy was 44%. These results suggest that SBRT to adrenal metastases was tolerated with low toxicity in limited metastatic patients and control rates are promising. This study supports the growing body of literature treating patients with adrenal metastases with SBRT.
Induction Spot Welding of Metal/CFRPC Hybrid Joints
Authors: Mitschang Peter , Velthuis Rudi , Didi Mirja
Published: January 2013

Today's areas of application for lightweight materials range from consumer goods and sports to high technology applications in transportation like aerospace or automotive. Thermoplastic composites manufactured by compression molding, thermoforming, tape laying, or injection molding will play a major role due to their weldability, their suitability for automated production (robot), and their recyclability. To reach a further step of weight reduction, the use of carbon fiber reinforced polymer composites (CFRPC) is unavoidable. A full substitution of metal is unlikely and new developments will consist of a combination of metal and CFRPC. This paper shows new developments in joining hybrids of metal (steel DC01 and aluminum AlMg3) and CFRPC (organic sheets CF‐PA66 and CF‐PEEK). Induction heating is chosen as appropriate joining technology for the bonding of metal/CFRPC as it is characterized by a rapid heating. An explanation of the process, the equipment, the influence of surface treatments, the characterization of the bonding mechanisms, as well as a first step to automation are presented. Basic experiments on the influence of pretreatments and process parameters show great influence of corundum blasting, acidic pickling and temperature control on the shear tensile strength. Joints shear tensile strength of 14.5 MPa for AlMg3/CF‐PA66 and of 20 MPa for DC01/CF‐PEEK, respectively is measured. The documentation of the process parameters shows a high reproducibility and reliability of the developed equipment and demonstrator parts are successfully manufactured.
Platinum(IV)‐Catalyzed Regioselective Synthesis of Highly Substituted 4H‐Cyclopenta[b]furans via Cascade Hetero‐ cyclization of 2‐(1‐Alkynyl)‐3‐aryl‐2‐propenals with Arylethenes
Authors: He Ting , Gao Pin , Zhao Shu‐Chun , Shi You‐Di , Liu Xue‐Yuan , Liang Yong‐Min
Published: January 2013

A platinum‐catalyzed cascade heterocyclization and formal [3+2] cycloaddition reaction of 2‐(1‐alkynyl)‐3‐aryl‐2‐propenals and arylethenes has been developed. This cyclization reaction shows excellent regioselectivity to obtain highly substituted 4H‐cyclopenta[b]furans in moderate to excellent yields.
Lower limb activity in the Cis‐Baikal: Entheseal changes among middle holocene siberian foragers
Authors: Lieverse Angela R. , Bazaliiskii Vladimir Ivanovich , Goriunova Olga Ivanovna , Weber Andrzej W.
Published: January 2013

Lower limb entheseal changes are evaluated in order to reconstruct activity levels and more fully understand cultural and behavioral variation among the middle Holocene (ca. 9,000–3,000 years BP) foragers of Siberia's Cis‐Baikal region. The four cemetery samples examined span a period of diachronic change characterized by an 800‐ to 1,000‐year discontinuity in the use of formal cemeteries in the region. Two of the cemetery samples represent the early Neolithic Kitoi culture, dating from 8,000 to 7,000/6800 cal. BP; the other two represent the late Neolithic‐early Bronze Age Isakovo‐Serovo‐Glazkovo (ISG) cultural complex, dating from 6,000/5,800 to 4,000 cal. BP. Findings suggest a dynamic pattern of cultural variability in the Cis‐Baikal, with spatial distribution (i.e., site location within particular microregions) appearing to be just as important a factor as cultural/temporal affiliation in explaining intersample differences in entheseal morphology. In addition, intrasample comparisons reveal increasing sexual disparity with advancing age at death, emphasizing the influence of sex‐related activities on lower limb entheseal changes. Finally, results from the separate fibrous and fibrocartilaginous datasets appear to be largely congruous, implying that activity patterns in the Cis‐Baikal may have similar effects on the morphology of both types of entheses. Am J Phys Anthropol, 2013. © 2013 Wiley Periodicals, Inc.
Hyperacute direct thrombus imaging using computed tomography and gold nanoparticles
Authors: Kim Dong‐Eog , Kim Jeong‐Yeon , Sun In‐Cheol , Schellingerhout Dawid , Lee Su‐Kyoung , Ahn Cheol‐Hee , Kwon Ick Chan , Kim Kwangmeyung
Published: January 2013

Objective

Advancing the understanding and management of thromboembolic stroke requires simple and robust new methods that would be useful for the in vivo assessment of thrombus burden/distribution and for characterizing its evolution in a prompt and quantitative manner.

Methods

Animals (n=127) with experimental models of thrombosis were imaged with microcomputed tomography 5 minutes (and/or ∼3 weeks) after intravenous injection of glycol chitosan (GC) gold nanoparticles (AuNPs).

Results

Nanoparticles accumulated in the thrombus, allowing computed tomography visualization of both the presence and extent of primary and recurrent thrombi in mouse carotid arteries without a single failure of detection. Nanoparticle thrombus imaging was also effective in monitoring the therapeutic efficacy of thrombolysis (n=118 tissue plasminogen activator [tPA] therapies). Thrombus evolution (either spontaneous or post‐tPA) could be mapped at high resolution in both space and time. Due to a long circulating half‐life, GC‐AuNPs remain available for entrapment into fibrin matrix for an extended period of time (up to 3 weeks), allowing repetition or ongoing monitoring of thrombogenesis and thrombolysis.

Interpretation

This is the first report on a hyperacute direct thrombus imaging technique using thrombus‐seeking AuNPs and computed tomography. When translated into stroke practice, the thrombus imaging may allow us to advance to personalized thrombolytic therapy by demonstrating thrombus burden, distribution, and character in a prompt and quantitative manner. Further study into this area is indicated. ANN NEUROL 2013;73:617–625
Use of Birth Certificates to Examine Maternal Occupational Exposures and Autism Spectrum Disorders in Offspring
Authors: Windham Gayle C. , Sumner Austin , Li Sherian X. , Anderson Meredith , Katz Elizabeth , Croen Lisa A. , Grether Judith K.
Published: January 2013

The continuing rise in the prevalence of autism spectrum disorders has led to heightened interest in the role of nongenetic factors, including exogenous exposures, but little research has been conducted. To explore a possible role in autism etiology, we used data available from our prior studies to examine potential occupational exposures, as these may occur at higher levels than environmental exposures. Parental occupation was obtained from birth certificates for 284 children with autism and 659 controls, born in 1994 in the San Francisco Bay Area. Self‐reported occupation and industry were coded into eight exposure/chemical groups based on potential neurotoxicity or reprotoxicity by a board‐certified physician in occupational medicine and an industrial hygienist blinded to case‐control status. Mothers of autistic children were twice as likely to work in occupations considered exposed (14.4%) as mothers of controls (7.2%) (adjusted odds ratio [AOR] 2.3 [95% confidence interval {CI} 1.3–4.2]). The exposure categories of the greatest frequency among case mothers were exhaust and combustion products (AOR = 12.0 [95% CI 1.4–104.6]) and disinfectants (AOR = 4.0 [95% CI 1.4–12.0]). Paternal occupational exposure was not associated with autism, potentially consistent with a direct in‐utero exposure effect. There are several limitations of this hypothesis‐generating study, including lack of detail on workplace and job duties, leading to possible misclassification and low proportion exposed. However, this misclassification would not be biased by case‐control status and is unlikely to explain the associations we did find, suggesting that further research on exogenous exposures may yield useful etiologic clues. Autism Res 2013, ●●: ●●–●●. © 2013 International Society for Autism Research, Wiley Periodicals, Inc.
Long‐term Effects of Prenatal Stress and Glucocorticoid Exposure
Authors: Painter Rebecca C. , Roseboom Tessa J. , de Rooij Susanne R.
Published: January 2013

There is a growing body of evidence suggesting that events during prenatal life can have long‐lasting effects on development and adult health. Stress during pregnancy is common and has been linked to increased incidence of a range of affective and behavioral outcomes in the offspring in later life and also some somatic outcomes. Glucocorticoids, and their actions on the fetus, which are regulated by placental 11β‐hydroxysteroid dehydrogenase type 2 (11β‐HSD2), are hypothesized to mediate these effects. Animal studies have demonstrated long‐term effects of stress and glucocorticoid administration on behavioral outcomes, as well as increased blood pressure, altered hypothalamic pituitary adrenal axis (HPA) function, and decreased glucose tolerance and brain size. In humans, licorice, which inhibits placental 11β‐HSD2 when consumed during pregnancy, has been shown to increase the risk of behavioral problems linked to altered HPA activity. Synthetic glucocorticoids administered during pregnancy to improve fetal lung maturity in threatened preterm birth have been shown to reduce birth weight and head circumference, but have not been linked to grosschanges in long‐term health todate. It is important to consider thelong‐term consequences of stress, and medication that mimics stress, during pregnancy. Birth Defects Research (PartC) 96:315–324, 2012. © 2013 Wiley Periodicals, Inc.
Preimplantation Stress and Development
Authors: Feuer Sky , Rinaudo Paolo
Published: January 2013

The developmental origins of health and disease hypothesis holds that inappropriate environmental cues in utero, a period marked by tremendous developmental sensitivity, facilitate cellular reprogramming to ultimately predispose disease in adulthood. In this review, we analyze if stress during early stages of development can affect future health. This has wide clinical importance, given that 5 million children have been conceived with assisted reproductive technologies (ART). Because the primary outcome of assisted reproduction procedures is delivery at term of a live, healthy baby, the postnatal effects occurring outside ofthe neonatal period are often overlooked. To this end, the long‐term outcome of ART is appropriately the most relevant concern of the field today. Evidence of adverse consequences is controversial. The majority of studies have concluded no obvious problems in IVF‐conceived children, although a number of isolated cases of imprinted diseases, cancers, or malformations have been reported. Given that animal studies suggest alteration of metabolic pathways following preimplantation stress, it will be of great importance to follow‐up ART individuals as they enter later stages of adult life. Birth Defects Research (Part C) 96:299–314, 2012. © 2013 Wiley Periodicals, Inc.
Using Natural Disasters to Study the Effects of Prenatal Maternal Stress on Child Health and Development
Authors: King Suzanne , Dancause Kelsey , Turcotte‐Tremblay Anne‐Marie , Veru Franz , Laplante David P.
Published: January 2013

Research on the developmental origins of health and disease highlights the plasticity of the human fetus to a host of potential teratogens. Experimental research on laboratory animals has demonstrated a variety of physical and behavioral effects among offspring exposed to prenatal maternal stress (PNMS). However, these studies cannot elucidate the relative effects of the objective stress exposure and the subjective distress in a way that would parallel the stress experience in humans. PNMS research with humans is also limited because there are ethical challenges to designing studies that involve the random assignment of pregnant women to varying levels of independent stressors. Natural disasters present opportunities for natural experiments of the effects of pregnant women's exposure to stress on child development. In this review, we present an overview of the human and animal research on PNMS, and highlight the results of Project Ice Storm which has been following the cognitive, behavioral, motor and physical development of children exposed in utero to the January 1998 Quebec Ice Storm. We have found that both objective degree of exposure to the storm and the mothers' subjective distress have strong and persistent effects on child development, and that these effects are often moderated by the timing of the ice storm in pregnancy and by the child's sex. Birth Defects Research (Part C) 96:273–288, 2012. © 2013 Wiley Periodicals, Inc.
The medtronic melody® transcatheter pulmonary valve implanted at 24‐mm diameter—it works
Authors: Cheatham Sharon L. , Holzer Ralf J. , Chisolm Joanne L. , Cheatham John P.
Published: January 2013

Objectives

We report the Melody valve implanted and/or expanded to 24‐mm diameter.

Background

The Medtronic Melody valve has been implanted up to 22 mm in the pulmonary position for over a decade.

Methods

A retrospective chart review was performed on 82 patients who underwent Melody valve implant. Technical implant method, pre‐ and postimplant echocardiographic findings, and initial follow‐up were reviewed.

Results

Between 04/2008 and 12/2011, 13 Melody valves were successfully implanted in 11 patients, median age 35 years (range 16–61 years), in the pulmonary (bioprosthetic valve, right ventricle to pulmonary artery conduit, native valve) position (n = 9), tricuspid position (bioprosthetic valve n = 3), and aortic position (bioprosthetic valve n = 1). Ten valves were delivered on a 24‐mm balloon in balloon catheter and three were implanted using a 22‐mm Ensemble balloon delivery system, followed by postdilation using a 24‐mm × 2‐cm Atlas balloon catheter. Postimplant, the median peak systolic gradient across the pulmonary valve was 7 mm Hg and median gradient across the tricuspid valve was 3 mm Hg. There was no change in gradient across the Melody valve in the aortic position where valve prosthesis–patient mismatch was present. Postimplant intracardiac echocardiography demonstrated none or mild valve regurgitation. No more than mild regurgitation was noted at a median follow‐up of 9.5 months.

Conclusions

The Melody valve can be implanted at 24 mm in the stenotic/regurgitant bioprosthetic pulmonary, tricuspid, and aortic valve, dysfunctional right ventricle to pulmonary artery conduit, and the native right ventricular outflow tract, whereas the valve remains competent with only mild regurgitation. © 2013 Wiley Periodicals, Inc.
Successful transcatheter closure of coronary artery fistula in a child with single coronary artery: A heavy load and a long road
Authors: Phasalkar Manjunath , Thakkar Bhavesh , Poptani Vishal
Published: January 2013

Single coronary artery is an uncommon variation of the coronary circulation. After transposition of great arteries, coronary artery fistulas are the most common associated cardiac anomalies in these patients. Transcatheter closure of coronary artery fistula (CAF) involving single coronary artery is a challenging intervention. In the absence of contralateral coronary artery, a complex anatomy of the CAF and a large myocardial perfusion territory of the dominant circulation pose an additional risk during interventional procedure. We report our experience of a successful transcatheter closure of a coronary artery fistula in a patient with single coronary artery. © 2013 Wiley Periodicals, Inc.
2‐(2′‐Pyridyl)‐4,6‐diphenylphosphinine versus 2‐(2′‐Pyridyl)‐4,6‐diphenylpyridine: Synthesis, Characterization, and Reactivity of Cationic RhIII and IrIII Complexes Based on Aromatic Phosphorus Heterocycles
Authors: de Krom Iris , Broeckx Leen E. E. , Lutz Martin , Müller Christian
Published: January 2013

The bidentate P,N hybrid ligand 1 allows access for the first time to novel cationic phosphinine‐based RhIII and IrIII complexes, broadening significantly the scope of low‐coordinate aromatic phosphorus heterocycles for potential applications. The coordination chemistry of 1 towards RhIII and IrIII was investigated and compared with the analogous 2,2′‐bipyridine derivative, 2‐(2′‐pyridyl)‐4,6‐diphenylpyridine (2), which showed significant differences. The molecular structures of [RhCl(Cp*)(1)]Cl and [IrCl(Cp*)(1)]Cl (Cp*=pentamethylcyclopentadienyl) were determined by means of X‐ray diffraction and confirm the mononuclear nature of the λ3‐phosphinine–RhIII and IrIII complexes. In contrast, a different reactivity and coordination behavior was found for the nitrogen analogue 2, especially towards RhIII as a bimetallic ion pair [RhCl(Cp*)(2)]+[RhCl3(Cp*)]− is formed rather than a mononuclear coordination compound. [RhCl(Cp*)(1)]Cl and [IrCl(Cp*)(1)]Cl react with water regio‐ and diastereoselectively at the external PC double bond, leading exclusively to the anti‐addition products [MCl(Cp*)(1H⋅OH)]Cl as confirmed by X‐ray crystal‐structure determination.
Three Polymorphic CdII Coordination Polymers Obtained from the Solution and Mechanochemical Reactions of 3‐Cyanopentane‐2,4‐dione with CdII Acetate
Authors: Yoshida Jun , Nishikiori Shin‐ichi , Kuroda Reiko , Yuge Hidetaka
Published: January 2013

We previously reported that monomeric and polymeric metal complexes are obtained from solution and mechanochemical reactions of 3‐cyano‐pentane‐2,4‐dione (CNacacH) with 3d metal acetates (M=MnII, FeII, CoII, NiII, CuII, and ZnII). A common feature found in all complexes was that their structural base is trans‐[M(CNacac)2]. Here, we report that the reactions of CNacacH with CdII acetate in the solution and solid states afford different coordination polymers composed of trans‐[Cd(CNacac)2] and cis‐[Cd(CNacac)2] units, respectively. From a methanol solution containing CNacacH (L) and Cd(OAc)2⋅2 H2O (M), a coordination polymer (Cd‐1) in which trans‐[Cd(CNacac)2] units are three‐dimensionally linked was obtained. In contrast, two different coordination polymers, Cd‐2 and Cd‐3, were obtained from mechanochemical reactions of CNacacH with Cd(OAc)2⋅2 H2O at M/L ratios of 1:1 and 1:2, respectively. In Cd‐2, cis‐[Cd(CNacac)2] units are two‐dimensionally linked, whereas the units are linked three‐dimensionally in Cd‐3. Furthermore, Cd‐1 and Cd‐2 converted to Cd‐3 by applying an annealing treatment and grinding with a small amount of liquid, respectively, in spite of the polymeric structures. These phenomena, 1) different structures are formed from solution and mechanochemical reactions, 2) two polymorphs are formed depending on the M/L ratio, and 3) structural transformation of resulting polymeric structures, indicate the usability of mechanochemical method in the syntheses of coordination polymers as well as the peculiar structural flexibility of cadmium‐CNacac polymers.
Encapsulation‐Induced Remarkable Stability of a Hydrogen‐Bonded Heterocapsule
Authors: Ichihara Keisuke , Kawai Hidetoshi , Togari Yuka , Kikuta Emi , Kitagawa Hitomi , Tsuzuki Seiji , Yoza Kenji , Yamanaka Masamichi , Kobayashi Kenji
Published: January 2013

Remarkably enhanced stability of the self‐assembled hydrogen‐bonded heterocapsule 1⋅2 by the encapsulation of 1,4‐bis(1‐propynyl)benzene 3 a was found with Ka=1.14×109 M−1 in CDCl3 and Ka2=1.59×108 M−2 in CD3OD/CDCl3 (10 % v/v) at 298 K. The formation of 3 a@(1⋅2) was enthalpically driven (ΔH°<0 and ΔS°<0) and there was a unique inflection point in the correlation between ΔH° versus ΔS° as a function of polar solvent content. The ab initio calculations revealed that favorable guest–capsule dispersion and electrostatic interactions between the acetylenic parts (triple bonds) of 3 a and the aromatic inner space of 1⋅2, as well as less structural deformation of 1⋅2 upon encapsulation of 3 a, play important roles in the remarkable stability of 3 a@(1⋅2).
Modeling of the Spray Zone for Particle Wetting in a Fluidized Bed
Authors: Heine Manuel , Antonyuk Sergiy , Fries Lennart , Niederreiter Gerhard , Heinrich Stefan , Palzer Stefan
Published: January 2013

In a spray agglomeration process the particle wetting influences the agglomerate growth and particle dynamics in the granulator. The mass of binder liquid that is deposited on single particles affects the amount of energy dissipation during particle contacts. For the agglomeration of colliding particles the whole impact energy has to be dissipated due to viscous and capillary adhesion forces in the liquid film and plastic deformation of the material. Therefore, a detailed knowledge of the particle wetting is necessary to model the agglomeration process. This contribution uses a coupled DEM‐CFD approach to describe the spray zone of a two‐fluid nozzle in a fluidized bed agglomerator. Droplets modeled as discrete elements showed the formation of a spray zone with a conical shape. Simulations of the spray zone and the wetting of single particles are in good agreement with experimental results.
Application of Adsorptive Reactors for the Reverse Water Gas Shift Reaction
Authors: Jung Sebastian , Reining Sven , Schindler Sarah , Agar David W.
Published: January 2013

Kohlendioxid kann als C1‐Baustein für chemische Reaktionen eingesetzt werden. Um die Reaktivität des Kohlendioxids zu erhöhen, wird dieses zuerst durch die reverse Wassergas‐Shift‐Reaktion (rWGS) mit Wasserstoff in einem adsorptiven Reaktor zu Kohlenmonoxid reduziert. Es wurden simulative und experimentelle Studien durchgeführt, um die Leistung eines adsorptiven rWGS‐Reaktors zu bewerten. Es zeigt sich, dass mithilfe des adsorptiven Reaktorkonzepts der Gleichgewichtsumsatz bei 225 – 250 °C deutlich erhöht werden kann.
Statistical inference for multivariate partially linear regression models
Authors: You Jinhong , Zhou Yong , Chen Gemai
Published: January 2013

In this paper we study a class of multivariate partially linear regression models. Various estimators for the parametric component and the nonparametric component are constructed and their asymptotic normality established. In particular, we propose an estimator of the contemporaneous correlation among the multiple responses and develop a test for detecting the existence of such contemporaneous correlation without using any nonparametric estimation. The performance of the proposed estimators and test is evaluated through some simulation studies and an analysis of a real data set is used to illustrate the developed methodology.The Canadian Journal of Statistics41: 1–22; 2013 © 2013 Statistical Society of Canada
Magnesium Ammonium Phosphate Production from Wastewater through Box–Behnken Design and Its Effect on Nutrient Element Uptake in Plants
Authors: Uysal Ayla , Kuru Begüm
Published: January 2013

This study examined ${\rm NH}_{{\rm 4}}^{{\rm + }} $, ${\rm PO}_{{\rm 4}}^{{\rm 3}- } $ recovery and the concentration of residual ions from anaerobic effluent of the potato processing industry through magnesium ammonium phosphate (MAP) precipitation using a Box–Behnken design. The regression model was statistically significant in terms of ${\rm NH}_{{\rm 4}}^{{\rm + }} $ and ${\rm PO}_{{\rm 4}}^{{\rm 3}- } $ removal efficiency and residual ion concentrations. Optimum ${\rm NH}_{{\rm 4}}^{{\rm + }} $ and ${\rm PO}_{{\rm 4}}^{{\rm 3}- } $ removal was obtained at pH 9.50 and at Mg2+/${\rm NH}_{{\rm 4}}^{{\rm + }} $/${\rm PO}_{{\rm 4}}^{{\rm 3}- } $ molar ratio of 1.8:1:1.8. Under these conditions, Mg, Ca, K, Fe, and Cl concentrations required for plant growth significantly decreased with MAP precipitation, which was supported by EDX analysis of dry MAP precipitate. The fertilizer effect of MAP on the growth of corn and tomato plants was compared with chemical fertilizers through pot trials. Nutrient element uptake levels of plants were examined in different fertilizer sources. While Mg, Fe, Cu, Mn, and Zn nutrient element uptake levels were sufficient in MAP pots, Ca uptake exceeded sufficient level. Average levels of N, P, K, Mg, Cu, and Mn of corn plant were higher in MAP than other pots. The average N, P, and Mg levels of tomato plant in MAP pots were higher than other pots. N/K ratio, which is important in tomato plants, was better optimized in MAP pots. Only Ni, Cr, and Pb heavy metals were found in plants.
A validation study of the FocalPoint GS imaging system for gynecologic cytology screening
Authors: Colgan Terence J. , Bon Nereo , Clipsham Susan , Gardiner Geoffrey , Sumner Jeff , Walley Virginia , McLachlin C. Meg
Published: January 2013

BACKGROUND:

Studies of the performance of the automated FocalPoint Guided Screening (FPGS) imaging system in gynecologic cytology screening relative to manual screening have yielded conflicting results. In view of this uncertainty, a validation study of the FPGS was conducted before its potential adoption in 2 large laboratories in Ontario.

METHODS:

After an intense period of laboratory training, a cohort of 10,233 current and seeded abnormal slides were classified initially by FPGS. Manual screening and reclassification blinded to the FPGS results were then performed. Any adequacy and/or cytodiagnostic discrepancy between the 2 screening methods subsequently was resolved through a consensus process (truth). The performance of each method's adequacy and cytodiagnosis vis‐a‐vis the truth was established. The sensitivity and specificity of each method at 4 cytodiagnostic thresholds (atypical squamous cells of undetermined significance or worse [ASC‐US+], low‐grade squamous intraepithelial lesion or worse [LSIL+], high‐grade squamous intraepithelial lesion or worse [HSIL+], and carcinoma) were compared. The false‐negative rate for each cytodiagnosis was determined.

RESULTS:

The performance of FPGS in detecting carcinoma, HSIL+, and LSIL+ was no different from the performance of manual screening, but the false‐negative rates for LSIL and ASC‐US were higher with FPGS than with manual screening.

CONCLUSIONS:

The results from this validation study in the authors' laboratory environment provided no evidence that FPGS has diagnostic performance that differs from manual screening in detecting LSIL+, HSIL+, or carcinoma. Cancer (Cancer Cytopathol) 2013;121:189–196. © 2013 American Cancer Society.
Resource provisioning based on preempting virtual machines in distributed systems
Authors: Salehi Mohsen Amini , Javadi Bahman , Buyya Rajkumar
Published: January 2013

Resource provisioning is one of the main challenges in large‐scale distributed systems such as federated Grids. Recently, many resource management systems in these environments have started to use the lease abstraction and virtual machines (VMs) for resource provisioning. In the large‐scale distributed systems, resource providers serve requests from external users along with their own local users. The problem arises when there is not sufficient resources for local users, who have higher priority than external ones, and need resources urgently. This problem could be solved by preempting VM‐based leases from external users and allocating them to the local ones. However, preempting VM‐based leases entails side effects in terms of overhead time as well as increasing makespan of external requests. In this paper, we model the overhead of preempting VMs. Then, to reduce the impact of these side effects, we propose and compare several policies that determine the proper set of lease(s) for preemption. We evaluate the proposed policies through simulation as well as real experimentation in the context of InterGrid under different working conditions. Evaluation results demonstrate that the proposed preemption policies serve up to 72% more local requests without increasing the rejection ratio of external requests. Copyright © 2013 John Wiley & Sons, Ltd.
A multi‐cell adaptive resource allocation scheme based on potential game for ICIC in LTE‐A
Authors: Ling Dabing , Lu Zhaoming , Ju Ying , Wen Xiangming , Zheng Wei
Published: January 2013

Intercell interference coordination in Third Generation Partnership Project long‐term evolution‐advanced system has received much attention both from the academia and the standardization communities. Moreover, the network architecture of long‐term evolution‐advanced system is modified to take into account coordinated transmission. In this article, we study the dynamic resource allocation problem and potential game theory and propose a multicell adaptive distributed resource allocation algorithm based on potential game. The allocation process is divided into two steps; subchannel is allocated first, and then, transmitted power is optimized dynamically according to a novel pricing factor. Besides, existence and uniqueness of Nash equilibrium of the proposed game model are assured. As a result, intercell interference is well coordinated. Simulation results show that transmitted power is saved efficiently and system fairness is improved to a large extent, accompanied with good performance gain of total and cell‐edge throughputs. Copyright © 2013 John Wiley & Sons, Ltd.
The 1,3‐Diamino‐1,2,3‐triazolium Cation: A Highly Energetic Moiety
Authors: Klapötke Thomas M. , Piercey Davin G. , Stierstorfer Jörg
Published: January 2013

The 1,3‐diamino‐1,2,3‐triazolium cation has been prepared by the amination of 1‐amino‐1,2,3‐triazole with O‐tosylhydroxylamine. The cation shows a very positive enthalpy of formation and is therefore highly suitable as the fuel component in new energetic materials. The cation was then paired with the energetic anions nitrate, nitrotetrazolate‐2‐oxide, 5,5′‐bis(1‐oxidotetrazolate), 5,5′‐azobis(1‐oxidotetrazolate), and nitriminotetrazolate and characterized. All the prepared compounds are high‐performance energetic materials, and when performances were compared with the corresponding triaminoguanidinium salt, those of 1,3‐diamino‐1,2,3‐triazolium were generally superior, as calculated by the EXPLO5 computer code. The heats of formation were calculated at the CBS‐4M level of theory. The impact, friction, and electrical spark sensitivities of the 1,3‐diamino‐1,2,3‐triazolium salts were measured and found to be easily initiated energetic materials.
Early‐Lanthanide Complexes with All‐Inorganic Macrocyclic Polyoxovanadate Ligands
Authors: Nishio Masaki , Inami Shinnosuke , Hayashi Yoshihito
Published: January 2013

Three discrete early‐lanthanide complexes with cyclic polyoxovanadate ligands, [LaV10O30]7– (1), [CeV9O27]6– (2), and [PrV9O27]6– (3), were synthesized by reaction of [VO3]– with early‐lanthanide(III) salts. Complexes 1–3 were composed of a LnIII center in square‐antiprism coordination mode with coordinated all‐inorganic ligands [VnO3n]n– (n = 9 or 10), which were constructed from a cyclic linkage of nine or ten VO4 tetrahedra through vertex sharing. Structural investigation of lanthanum complex 1 revealed a ten‐membered ring of VO4 units in which eight VO4 units were coordinated to the lanthanum atom through their oxido groups and two VO4 units at opposite sides of the ring were not coordinated. Cerium complex 2 and praseodymium complex 3 both contained a nine‐membered cyclic ligand with eight VO4 coordinated units and one uncoordinated unit among nine tetrahedral VO4 units. 51V NMR spectra of 1–3 in acetonitrile showed reversible temperature dependences at –40–70 °C, thus indicating fluxional behavior of the macrocyclic polyoxovanadate ligands in solution. Exchange of the coordinated and uncoordinated VO4 sites in the ring was responsible for these reversible processes.