bluuebunny/crossref_metadata_2025 huggingface dataset:
Next Generation EHRs – What Problems Are These Systems Aiming to Solve?
Authors: Schmidt Thomas  , Nøhr Christian  , Vingtoft Søren  , Turner Paul
Published: February 2025

EHRs elicit an array of different aspirations all underpinned by the widely held conviction that they can deliver benefits for patients, clinicians, researchers, IT vendors, policy-makers and society as a whole. While techno-centric visions abound, reflection on their history, the challenges evident in their design, implementation and evaluation and the limited evidence of their beneficial impacts over time is instructive. From a socio-technical perspective EHRs appear to be a set of ‘wicked problems’ unlikely to be resolved in favor of one position or another, but rather requiring judgement, nuance and negotiation around the kinds of problems we want these systems to solve. This paper presents some perspectives on important potential features for next generation EHRs and on the types of problems that these systems could aspire to solve. The focus is not on prediction but rather on actively shaping the kind of future that we desire and how EHRs will support its achievement.
From Siloed Applications to National Digital Health Ecosystems: A Strategic Perspective for African Countries
Authors: Stroetmann Karl A.
Published: February 2025

Substantial investment in digital solutions for improved health services has occurred in recent years in Africa. Digital Health provides for proven, beneficial applications in many different areas of health systems. It supports the transformation of healthcare delivery, and its potential is seemingly boundless. However, the deployed systems are in silos, and interoperability and integration are largely missing. There is no timely information for easy and quick decision making; there is no ability to track service levels across the whole health sector. What is missing is an integrated information system across all healthcare facilities nationwide. Such a Digital Health Ecosystem, the holistic application of information and communications technologies, services and applications, will support health systems and improve healthcare delivery, coordination and integration across providers. Based on global experience in resource-constraint contexts, core steps necessary to develop and implement such an ecosystem are explored, and four fundamental building blocks and their elements are developed. The results presented are succinctly integrated into six statements on lessons learned and recommendations.
Design for a Canadian Digital Health Policy & Practices Observatory
Authors: Walimohamed Fahreen  , Aggarwal Monica  , Dong Linying  , Lattimer Rory  , Hakim Zaki  , Goranson David  , Ubhi Kiran  , Ali Minhas  , Shachak Aviv  , Guergachi Aziz  , Keshavjee Karim
Published: February 2025

Canada has struggled to make digital health a reality. We identified 6 key issues that appear to impede progress: 1) an inability to coordinate the actions of a rapidly evolving set of stakeholders, 2) patients who lack the ability and resources to play a meaningful role in health system decision-making, 3) world-class innovation that doesn't reach the market, 4) an inability to kick-start interoperability projects that can catalyze system transformation, 5) an inability to procure early-stage innovative technologies at scale, and 6) an inability to share data seamlessly across organizational silos for patient coordination and care, health system management and research. We propose a set of policies and practices that can help Canada assess, monitor and provide feedback to stakeholders and citizens on how well they are progressing toward seamless digital health.
Rule-Based Data Quality Assessment and Monitoring System in Healthcare Facilities
Authors: Wang Zhan  , Dagtas Serhan  , Talburt John  , Baghal Ahmad  , Zozus Meredith
Published: February 2025

Measuring and managing data quality in healthcare has remained largely uncharted territory with few notable exceptions. A rules-based approach to data error identification was explored through compilation of over 6,000 data quality rules used with healthcare data. The rules were categorized based on topic and logic yielding twenty-two rule templates and associated knowledge tables used by the rule templates. This work provides a scalable framework with which data quality rules can be organized, shared among facilities and reused. The ten most frequent data quality problems based on the initial rules results are identified. While there is significant additional work to be done in this area, the exploration of the rule template and associated knowledge tables approach here shows rules-based data quality assessment and monitoring to be possible and scalable.
EHR Usage Problems: A Preliminary Study
Authors: Wawrzyniak Clément  , Marcilly Romaric  , Baclet Nicolas  , Hansske Arnaud  , Pelayo Sylvia
Published: February 2025

Electronic health record (EHR) systems were initially developed to improve health care delivery by facilitating the healthcare professionals' access to electronically-stored patient information, but problems are regularly reported in the literature. We present here a preliminary study conducted at a 950-bed university hospital. They have implemented an EHR in 2012 to remove their paper-based system. After few years, physicians complain that the EHR is “too complex”, “too slow”, “unsatisfying”, and “which interacts with too many health software”. This preliminary study was based on individual interviews inspired from critical incident technique with 9 hospital professionals (physicians and pharmacist) to establish a global diagnostic of the EHR's usability failures/difficulties and their potential impacts. Results show that professionals faced to many constraints impacting their work but more importantly the patient care, with recent outstanding examples. This work is a first step of a larger study to help the hospital to map usability failures, their context of use and associated risks/impacts, and to provide solutions to fix it.
International Standard Accident Number: A Master Case Index Linking Accident & Emergency with Medical Data
Authors: Le Hoang Phi  , Hackel Siegfried  , Guenther Andreas  , Goldschmidt Raimar  , Daoud Melhem  , Deserno Thomas M.
Published: February 2025

Unconnected data silos make it difficult to view a patient's accident and emergency case in a comprehensive way, i.e. across all sectors. This includes the emergency medical services (EMS), medical data in a hospital's electronic health record (EHR) as well as event data recorders (EDRs) collecting information about the circumstances of the accident and emergency event. In this paper, we propose a conceptual architecture which introduces a novel case-based record linkage approach and the international standard accident number (ISAN) as a master case index for linking data from EDR, EMS, and EHR.
A Report on Archetype Modelling in a Nationwide Data Infrastructure Project
Authors: Wulff Antje  , Sommer Kim Katrin  , Ballout Sarah  , HiGHmed Consortium  , Haarbrandt Birger  , Gietzelt Matthias
Published: February 2025

Background: The nationwide data infrastructure project HiGHmed strives for achieving semantic interoperability through the use of openEHR archetypes. Therefore, a knowledge governance framework defining collaborative modelling processes has been established. For long-sustained success and the creation of high-quality archetypes, continuous monitoring is vital.
From ObsCare Software to an OpenEHR Platform: Modelling Obstetric Archetypes
Authors: Maranhão Priscila A.  , Pereira Ana Margarida  , Bacelar-Silva Gustavo  , Gonçalves-Ferreira Duarte  , Vieira-Marques Pedro  , Silva-Costa Tiago  , Cruz-Correia Ricardo J.
Published: February 2025

Introduction and aims. Electronic health records (EHRs) are important tools to facilitate communication between care providers and to improve clinical research. In obstetrics they became essential. The ObsCare software was created to answer to the need for an EHR with specific obstetric features. The present study aimed to develop openEHR-archetypes capable of representing an ObsCare® EHR form and to create an openEHR-template using the developed archetypes.
Uncertainty-Adjusted Translation for Preference-Sensitive Decision Support
Authors: Dowie Jack  , Kaltoft Mette Kjer
Published: February 2025

In Multi-Criteria Decision Analysis-based decision support for person-centred care, the person's quantitative preferences (as criterion weightings) are combined with quantified evidence and expert assessments (as option performance ratings on all criteria) to produce a personalised quantified opinion (as a set of expected value option scores). In our current decision support tools, we use the best available (central point) estimates for option performance ratings. The uncertainty surrounding the performance rating estimates, routinely reported by researchers as intervals around the means, are ignored. While defensible, this paper responds to questioning of this disregard. Apart from the inappropriate ‘inverse variance’ method, we find no attempt to integrate parameter uncertainty into decision analyses, simply an emphasis on reporting it fully, leaving decision makers unsupported in the burden of dealing with the separated outputs – e.g. Means and Credible Intervals. The paper suggests that uncertainty can be brought within Multi-Criteria Decision Analysis-based decision support by treating the means and uncertainties of all outcomes and process considerations as separate criteria, having them traded-off in an individually preference-sensitive manner at the point of decision. An empirical proof of method via an online example on bone health medications is provided, involving six options, two considerations and four criteria.
Discovering Monogenic Causes of Multi-Diseases by Mining Electronic Medical Records and Genetics Repositories
Authors: Kulenovic Adnan  , Lagumdzija-Kulenovic Azra
Published: February 2025

We present a method called SMDG (Single Multi-Disease Genes) for systematic discovery of monogenic causes of multi-diseases. Multi-disease conditions, quite common in older populations, are difficult to treat due to missing their precise medical guidelines and need for attention of multiple health care providers. Finding monogenic causes of these diseases would enable introducing new therapeutic approaches, focused on the remediation of mutations of single genes. SMDG is based on the hierarchical divisive clustering of electronic medical records (EMR) that include genetic data, and on the analysis of the public gene-to-disease and gene-to-gene repositories. The method was tested on the database of the Harvard Personal Genome Project (PGP), the gene-to-disease repository DisGeNET and the gene-to-gene interactions repository BioGRID. It identified possible new monogenic causes of selected multi-diseases, which were confirmed as valid hypotheses by examining related research papers.
Pay for Performance in Electronic Data Capture for Clinical Trials and Medical Registries
Authors: Rahimbayli Sattar  , Lehmann Jens  , Deserno Thomas M.
Published: February 2025

Following the new medical device regulations, vendors need to track their products. Unlike to clinical research, data entry in such registries is done by staff that basically needs to ensure resident's treatment. Enforcing data completeness while entering is not an option anymore. In this work, we suggest an independent pay for performance system, that connects via REST to the registries. It allows to define rules that check data consistency and completeness, and rewards for records that fulfill the requirement. Rewards can be calculated manually or automatically by triggering evens, and they sum up for data entry persons or recruiting centers.
Reviving 30 Year Old Technology: Lessons Learned from Transferring Patient Data Using Data Matrix Codes
Authors: Brix Tobias Johannes  , Neuhaus Philipp  , Storck Michael  , Soto-Rey Iñaki  , Dugas Martin
Published: February 2025

In patient care and medical research patient data often has to be transferred between different electronic systems. These systems can be very heterogeneous, sometimes even legacy systems, and thus, often do not support standardized interfaces for data transfer. Since nowadays barcode scanners are commonly used in clinical routine and smartphones are accessible to most patients, we implemented different interfaces based on Data Matrix codes to transfer patient data between several medical applications. Objective of this work is to show different use cases in which Data Matrix codes have been successfully applied and discuss the lessons we have learned during the process of implementation and practical usage.
Exploratory Analysis of Motion Tracking Data in the Rehabilitation Process of Geriatric Trauma Patients
Authors: Altenbuchner Amelie  , Haug Sonja  , Weber Karsten
Published: February 2025

Background: This article is based on an ongoing long-term study, in which customary motion trackers measure steps during rehabilitation of geriatric trauma patients (Med=86 years).
Health Care Atlases: Informing the General Public About the Situation of the Austrian Health Care System
Authors: Rippinger Claire  , Weibrecht Nadine  , Zechmeister Melanie  , Scheffel Sonja  , Urach Christoph  , Endel Florian
Published: February 2025

There is a great number of complex data concerning the Austrian Health Care System. The goal was to process this data and present it to the general public on an easily accessible information platform. The platform focuses on data about the burden of disease of the Austrian Population, the available medical care and the services provided by the physicians. Due to the vast differences in the underlying source data, the methods used for the data acquisition range from statistical linkage over web scraping to aggregating data on the reimbursed services. The results are published on a website and are mainly displayed with interactive graphics. Overall, these dynamic and interactive websites provide a good overview of the situation of the Austrian Health Care System and presents the information in an intuitive and comprehensible manner. Furthermore, the information given in the atlases can contribute to the health care planning in order to identify distinctive service provision in Austria.
Optimization of Clinical Decision Support Based on Pearson Correlation of Attributes
Authors: Dudchenko Aleksei  , Ganzinger Matthias  , Kopanitsa Georgy
Published: February 2025

Clinical decision support is very important especially in such a wide-spread disease as a coronary artery disease. A large variety of prediction methods can potentially solve the classification problem to support clinical decisions. However, not all of them provide similar efficiency for the classification of patients with coronary artery disease. We have analyzed prediction the efficiency of classifiers (Ridge Classifier, XGB Classifier and Logistic Regression) depending on the number and combination of features. We have tested 24 sets of features on 4 classifiers to proof the hypothesis that using optimized features sets with a higher Pearson ratio results in more efficient classifiers than using all available data.
A SOA Based Solution for MDRO Surveillance and Improved Antibiotic Prescription in the Abruzzo Region
Authors: Gazzarata Roberta  , Monteverde Maria Eugenia  , Bonetto Monica  , Savini Vincenzo  , Polilli Ennio  , Corridoni Serena  , Costantini Alberto  , Santoleri Fiorenzo  , Rapacchiale Giorgia  , Palmieri Dalia  , Melena Stefania  , Di Girolamo Arturo  , Sciacca Antonina  , De Benedictis Marco  , D'Alberto Heber  , Galleani Giacomo  , Giacomini Mauro  , Parruti Giustino
Published: February 2025

Prevention and control of hospital and community acquired infections caused by multi drug resistant organisms (MDROs) are one major priority nowadays for health care systems worldwide. To improve actions and plans to tackle this problem, the creation of automated regional, national and international MDRO surveillance networks is a mandatory path for international health Institutions and Ministries. In this paper, the authors report on the surveillance system designed for the Abruzzo Region (Central Italy) to monitor the prevalence of MDROs in both infected and colonized patients, to verify appropriateness of antibiotic prescription in hospitalized patients and to interact with other national and sovra-national networks. Service Oriented Architecture (SOA) approach, different Healthcare Service Specification Project (HSSP) standards, local, national and international terminology and Clinical Document Architecture Release 2 (CDA R2) were adopted to design the overall architecture of this regional surveillance system. The Authors discuss the state of implementation of the project, itemizing specific design and implementation choices adopted so far and sketching next steps and reasons of some design and implementation choices, and indicate the next steps.
Characterising Physical Rehabilitation Exergames for Player Experience Evaluation Purposes
Authors: Gamboa Edwin  , Trujillo Maria
Published: February 2025

The constraints that physical rehabilitation exergames (PREGs) may impose on Player Experience (PX) evaluation should be identified from a physiotherapists' perspective. In this paper, we present the results of a qualitative study to identify the characteristics and constraints that are relevant to evaluate PX in PREGs. The study included semi-structured interviews conducted during two sessions with three physiotherapists from a local hospital. The collected data was analysed using the thematic content analysis method. The findings indicate that the PX evaluation constraints are related to (a) the rehabilitation context in which PREGs are employed; (b) the pursued rehabilitation goal (i.e., the capability of a PREG to assist the achievement of a rehabilitation goal); and (c) the characteristics of target patients, which may affect their experience and willingness to play. The findings of the study contribute to a comprehensive understanding of PX in PREGs. We concluded that the three groups of constraints may impact the three constructs of PX; i.e., context (rehabilitation context), player (patient) and game system (PREG system). Confirming the need to propose or extend PX models of entertaining games for the case of PREGs.
Development and Usability Evaluation of Web-Based Telerehabilitation Platform for Patients After Myocardial Infarction
Authors: Jameie Saba  , Haybar Habib  , Aslani Azam  , Saadat Maryam
Published: February 2025

Introduction: Cardiac rehabilitation (CR) is a multidisciplinary intervention that improves quality of life and reduces the risk of recurrent heart attack. Unlike all known benefits for CR, the patient participation in CR is low. Telerehabilitation has the potential to improve lifestyle and helps patients having long-term compliance with clinician advice. The objective of this study was the development of a web-based cardiac telerehabilitation platform to engage the post-myocardial infarction (MI) patients in self-management of disease.
Pola Komunikasi Guru dan Siswa Dalam Mengaplikasikan Program Pemahaman Adat dan Alam di Sekolah Alam Kebon Bagea Ciwidey Jawa Barat
Authors: Amalliah  , Wisnu Satria  , Flora Meliana Sihaan
Published: February 2025

Penelitian ini menginvestigasi pola komunikasi antara guru dan siswa dalam implementasi program pemahaman adat dan alam di Sekolah Alam Kampung Bagea Ciwidey, di tengah tantangan budaya asing yang semakin meluas di Indonesia. Fokus utama adalah memahami bagaimana interaksi komunikatif ini memengaruhi efektivitas program dalam menjaga dan mengembangkan kearifan lokal. Metode penelitian yang digunakan adalah kualitatif deskriptif, melibatkan observasi langsung, wawancara mendalam, dan dokumentasi. Hasil penelitian menunjukkan bahwa pola komunikasi yang terbuka dan berorientasi pada kolaborasi antara guru dan siswa memiliki peran krusial dalam kesuksesan implementasi program, mempromosikan pemahaman mendalam tentang adat dan alam, serta memperkuat identitas lokal dalam menghadapi arus globalisasi budaya dan tentunya dengan pendekatan komunikasi interpersonal antara guru dan murid juga salah satu peranan penting dalam kesuksesan program pemahaman adat dan alam. Implikasi temuan ini menggarisbawahi pentingnya komunikasi efektif dalam konteks pendidikan berkelanjutan yang berpusaat pada nilai-nilai keberlanjutan dan kearifan lokal.
Peran dan Tugas Staf Admin Dalam Mengelola Absensi Pegawai Menggunakan Aplikasi Bravo PUPR pada Balai Pengembangan Kompetensi PUPR Wilayah III Jakarta
Authors: Unik Desthiani  , Ratna Suminar  , Nuryanah
Published: February 2025

Penulisan ini tentang peran dan tugas staf administrasi dalam mengelola absensi pegawai menggunakan aplikasi Bravo PUPR di Balai Pengembangan Kompetensi PUPR Wilayah III Jakarta. Tujuan dari laporan Tugas Akhir ini adalah untuk mengetahui peran dan tugas staf administrasi di Balai Pengembangan Kompetensi PUPR Wilayah III Jakarta dan untuk mengetahui hambatan staf admin dalam mengelola absensi pegawai. Metode penulisan tugas akhir ini adalah melalui observasi atau pengamatan yang dilakukan penulis mengenai peran dan tugas staf administrasi dalam mengelola absensi pegawai menggunakan aplikasi Bravo PUPR di Balai Pengembangan Kompetensi PUPR Wilayah III Jakarta. Berdasarkan data, ada tiga kendala yang dihadapi staf administrasi yaitu  masih adanya staf admin yang belum memahami penggunaan aplikasi Bravo PUPR, seringnya terjadi gangguan koneksi internet dan kurangnya ketelitian staf admin dalam melaksanakan proses rekap absensi. Penulis menyarankan Balai Pengembangam Kompetensi PUPR Wilayah III Jakarta perlu menyelenggarakan pelatihan seperti bimbingan teknis, sosialisasi/internalisasi dan pelatihan pengembangan kompetensi lainnya terkait penggunaan aplikasi Bravo PUPR bagi para pegawai serta staf admin agar seluruh pegawai memahami aplikasi tersebut dengan baik, Balai Pengembangan Kompetensi PUPR Wilayah III Jakarta menyiapkan jaringan internet backup dengan vendor penyedia layanan internet yang berbeda dari penyedia utama, Balai Pengembangan Kompetensi PUPR Wilayah III Jakarta perlu mengusulkan adanya pengawas atau verifikator staf admin agar staf admin lebih teliti pada saat melakukan pengelolaan rekap absensi.
Pengaruh Gaya Kepemimpinan dan Komunikasi Organisasi Terhadap Kinerja Karyawan pada PT Limaurent Jakarta Selatan
Authors: Fauziah Gina , Ghibran Dwi Pangga Muhammad
Published: February 2025

Dalam penelitian ini bertujuan untuk mengetahui pengaruh antara gaya kepemimpinan  dan komunikasi kerja terhadap kinerja karyawan pada PT Limau Rental Jakarta Selatan. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif. Jumlah populasi pada penelitian ini berjumlah 35 responden. Teknik pengambilan sampel menggunakan sampling jenuh dan diperoleh sampel sebanyak 35 responden. Analisis data menggunakan uji validitas, uji reliabilitas, uji asumsi klasik, analisis regresi linear sederhana dan berganda, koefisien korelasi, koefisien determinasi, dan uji hipotesis. Hasil penelitian ini adalah variabel gaya kepemimpinan secara parsial berpengaruh positif dan signifikan terhadap kinerja karyawan dengan nilai t hitung (7,394 > 2,037) dan nilai sig 0,001 < 0,05. Hal ini menunjukkan bahwa H0 ditolak dan H1 diterima. Variabel komunikasi organisasi secara parsial berpengaruh positif dan signifikan terhadap kinerja karyawan dengan nilai thitung  (16,372 > 2,037) nilai sig 0,001 < 0,05. Hal ini menunjukkan bahwa H0 ditolak dan H2 diterima. Berdasarkan uji hipotesis F (Simultan) dapat diketahui bahwa nilai Fhitung (131,239 > 3,295) dan nilai signifikan 0,001 < 0,05. Maka dapat dapat disimpulkan bahwa H0 ditolak dan H3 diterima. Hal ini berarti Gaya Kepemimpinan dan komunikasi organisasi secara simultan berpengaruh positif dan signifikan terhadap kinerja karyawan pada PT Limaurent Jakarta Selatan. Besarnya R-Square Pada variabel gaya kepemimpinan sebesar 62,4% sedangkan sisanya 37,6% dan koefisien determinasi (R-squaare) pada variabel komunikasi organisasi sebesar 89,0% dan sisanya sebesar 11,0 % selanjutnya untuk koefisien derteminasi (R2) adalah sebesar 0,891 atau 89,1% dan sisanya 10,9 % dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini.
Dampak Jual Beli Online Terhadap Pedagang Kaki Lima di Pasar Tradisional Ciputat Tangerang Selatan
Authors: Zainal Arifin Zaki , Turkamun  , Hasanah Thorik Sylvia
Published: February 2025

Perkembangan teknologi informasi telah membawa perubahan besar baik dari segi produksi maupun dari segi pemasaran dan dari segi pasar konsumenpun juga berubah. Produsen selalu dituntut untuk berinovasi mengikuti tends pasar yang menjadi kesukaan konsumen. Dari segi pemasaran produk yang tadinya dilakukan dengan cara beriklan di televisi atau media cetak dengan biaya mahal sekarang pemasaran produk cukup melalui media internet atau menggunakan media sosial dengan biaya murah dan cepat. Dari segi pasar konsumenpun berubah yang tadinya belanja kita harus datang ke pasar atau toko-toko swalayan sekarang konsumen cukup dengan gedgetnya pilih situs-situs Online, pesan barang yang kita inginkan akan cepat kita dapatkan. Bisnis Online berkembang sangat pesat tanpa mengenal batas waktu dan tempat, jual beli melalui internet sebagai media penghubung dan website sebagai katalog pemasaran lebih praktis dan efisien karena tidak mengharuskan pertemuan langsung antara penjual dengan pembeli, bahkan bisnis Online jangkauannya lebih luas bisa mencapai seluruh dunia, itulah yang membuat bisnis Online sangat diminati banyak orang, dilihat dari segi pelayanan, efektifitas, keamanan dan popularitas. Dengan adanya internet sebuah paradigma baru lahir dunia disibukkan oleh pengguna internet terutama oleh pelaku bisnis hal ini akan berdampak keuntungan bagi pelaku e-commerce dan e-bussines. Pengetahuan teknologi internet sangat berpengaruh terhadap asing yang diharapkan pengguna dalam bertransaksi melalui website, hasil yang diharapkan outcom expectation dapat memperkirakan sebuah tingkah laku yang akan menghasilkan sesuatu.
Explainable AI for Large-Scale Predictive Systems: Techniques, Applications, and Future Directions
Authors: Priyadharshini Krishnamurthy
Published: February 2025

This article provides a comprehensive examination of Explainable Artificial Intelligence (XAI) techniques and their applications in large-scale predictive systems. The article explores both model-agnostic and model-specific approaches, examining their effectiveness in various domains including healthcare, finance, and transportation. The article explores fundamental XAI concepts, historical development, and current taxonomies while addressing crucial regulatory and ethical considerations. The article examines feature importance methods, partial dependence plots, SHAP values, LIME, and counterfactual explanations as key model-agnostic techniques. It further delves into model-specific approaches including decision tree interpretability, neural network visualization, attention mechanisms, rule extraction methods, and architecture-specific approaches. The article extensively covers domain applications, highlighting how XAI enhances transparency and trust in critical sectors. The article also addresses significant challenges including scalability issues, interpretation complexity, computational overhead, accuracy-explainability trade-offs, and human factors in XAI implementation. This article contributes to the understanding of XAI's current state and future directions in large-scale predictive systems.
Automated Design of Piecewise Linear Approximations based QFT Controllers for Time Delay Systems
Authors: Makwana Dipesh , Gotmare Akash
Published: February 2025

Time-delay systems are prevalent in various industrial and engineering applications, introducing significant challenges in control design due to their inherent instability and performance degradation. This paper presents a robust control design methodology based on Piecewise Linear Approximation and Linear Programming (PLA-LP) within the Quantitative Feedback Theory (QFT) framework for handling uncertain time-delay systems. In this work, time delay is approximated using a first-order Pade approximation. The proposed methodology ensures robust stability and performance by shaping the loop transfer function to satisfy given stability and tracking constraints. The design problem validates the effectiveness of the approach, demonstrating its capability to design controllers that achieve the desired closed-loop behavior under uncertainty. The results confirm that the PLA-LP-based QFT design method provides a computationally efficient and systematic approach to synthesizing controllers for uncertain time-delay systems while maintaining robustness against plant uncertainties.
РОЛЬ ІНФОРМАЦІЙНИХ ТЕХНОЛОГІЙ В СУЧАСНІЙ УКРАЇНСЬКІЙ ВІЙСЬКОВІЙ СПРАВІ
Authors: ЛУК’ЯНЕНКО Сергій , ВДОВІН Павло , ГРОМИКО Валентин , ТИМОШЕНКО Роман
Published: February 2025

У статті досліджено питання щодо ролі інформаційних технологій в сучасній українській військовій справі. Мета роботи полягає в аналізі того, як інформаційні технології впливають на ефективність протистояння України агресору та сприяють відновленню країни після війни, зокрема через інституційні реформи та інтеграцію до європейських стандартів. Методологія дослідження включає аналіз використання цифрових систем управління, розвідки, кібербезпеки та їх вплив на ведення бойових дій, а також на процеси відновлення країни після конфлікту. Наголошено на тому, що наразі основний фокус України спрямований на протистояння агресору, звільнення своїх територій та пошук шляхів відновлення економіки як під час війни, так і після перемоги, з акцентом на швидку реконструкцію країни. Завдання полягає не тільки в мінімізації збитків і подоланні наслідків руйнувань, але й у закладенні основ для майбутнього економічного зростання. Фундамент цього розвитку включає інституційні реформи відповідно до європейських стандартів, інтеграцію транспортної, енергетичної та соціальної інфраструктури до європейського ринку, створення сприятливого інвестиційного середовища для інвесторів та постачальників технологій, а також відновлення міст з використанням сучасних технологій дизайну та міського планування. Також важливим є розвиток транспортних систем і відновлення соціального капіталу, що сприятиме здатності громадян до спільних дій задля досягнення спільних цілей. Наукова новизна роботи полягає в оцінці важливості ІТ у військовій справі як елементу стратегічної оборони та розвитку інфраструктури України в умовах війни. Як висновок, сказано про те, що інформаційні технології стали ключовим фактором у сучасній військовій справі, зокрема у протистоянні України російській агресії. Впровадження цифрових систем управління, засобів розвідки та кібербезпеки дозволяє значно підвищити ефективність ведення бойових дій. Хоча Україна зіткнулася з великими викликами на цьому шляху, активний розвиток інформаційних технологій дає змогу досягти значних успіхів як на полі бою, так і в захисті національних інтересів у кіберпросторі. Роль ІТ у сучасній українській військовій справі буде тільки зростати, і для подальшого підвищення обороноздатності країни необхідно розвивати технологічні спроможності та залучати інноваційні підходи. Успішне використання інформаційних технологій може стати тим вирішальним фактором, який забезпечить перемогу України в цьому конфлікті. Висновки свідчать, що впровадження інформаційних технологій значно підвищує ефективність ведення бойових дій і сприяє розвитку інфраструктури та соціального капіталу, що є важливими для майбутнього економічного зростання країни. Для подальшого зміцнення обороноздатності України необхідно активно розвивати технологічні спроможності та залучати інноваційні підходи. Впровадження ІТ в військову справу є вирішальним фактором для здобуття перемоги в конфлікті.
ПРОБЛЕМИ КОНФІДЕНЦІЙНОСТІ ТА ЕТИКИ У ВИКОРИСТАННІ ВІДКРИТИХ ДАНИХ ДЛЯ РОЗРОБКИ ДОДАТКІВ
Authors: ГОРДІЄНКО Олександр , КОВАЛЬ Аліна
Published: February 2025

У сучасну епоху цифрових технологій відкриті дані стали потужним ресурсом для розробки інноваційних додатків. Вони забезпечують розробників доступом до цінної інформації, яка сприяє створенню рішень для різноманітних сфер – від медицини до транспорту, від освіти до урбаністики. Проте використання відкритих даних викликає низку питань, пов'язаних із конфіденційністю та етикою. Як балансувати між необхідністю вільного доступу до інформації та захистом приватності? Як забезпечити етичне використання даних у додатках, що впливають на життя мільйонів людей? У цій статті ми розглянемо ключові проблеми конфіденційності та етики у контексті використання відкритих даних для розробки додатків. Мета статті. Проаналізувати етичні та конфіденційні аспекти використання відкритих даних у процесі розробки програмних додатків, визначити ключові проблеми, пов'язані з захистом приватності користувачів, та запропонувати рекомендації для дотримання етичних принципів при роботі з відкритими даними. Методологія. Проведено аналіз нормативно-правових актів, які регулюють використання відкритих даних. Використано кейс-аналіз реальних прикладів, коли використання відкритих даних викликало етичні або конфіденційні суперечності. Проведено опитування та інтерв’ю з розробниками додатків і експертами в галузі даних, щоб виявити їхні підходи та труднощі у роботі з відкритими даними. Систематизовано ризики через порівняння теоретичних концепцій конфіденційності з практичними викликами. Наукова новизна. Представлено новий підхід до класифікації етичних викликів при використанні відкритих даних у розробці додатків, враховуючи їхній вплив на різні стейкхолдери. Описано механізми виявлення прихованих ризиків для конфіденційності користувачів при інтеграції відкритих даних у програмні продукти. Розроблено рекомендації щодо впровадження етичних стандартів у життєвий цикл розробки додатків, включаючи етапи збору, аналізу та інтеграції відкритих даних. Висновок. Використання відкритих даних у розробці додатків створює значні етичні та конфіденційні ризики, які можуть порушувати права користувачів та знижувати довіру до програмних продуктів. Для мінімізації цих ризиків необхідно впроваджувати етичні стандарти на всіх етапах розробки, розробляти механізми захисту даних, дотримуватись правових норм і створювати прозорі політики щодо використання інформації. Ефективне управління конфіденційністю сприятиме гармонізації інтересів розробників, користувачів і суспільства.
Microbiome composition of pneumonia in domestic pigs in Ukraine
Authors: Kokariev A. V. , Masiuk D. M. , Nedzvetsky V. S. , Harashchuk M. I.
Published: February 2025

Respiratory pathology in pigs is a widespread issue in global pig farming. The etiology of pneumonia varies and can significantly differ between regions. Periodically, new pathogens inducing respiratory diseases in pigs, including respiratory organs, are discovered worldwide. Therefore, the aim of our work was to determine the microbiome structure of pneumonia in domestic pigs in Ukraine. Fragments of lung tissue were collected for research from deceased pigs with signs of respiratory pathology. A total of 87 cases of pig pneumonia from 62 pig farms located in 20 different regions of Ukraine were investigated. Using the qPCR method, genes of 13 microorganisms were identified: PCV 2, PCV 3, SIV type A, SIV type D, PRRSV EU, A. pleuropneumoniae, A. suis, M. hyopneumoniae, M. hyorhinis, S. suis, P. multocida, B. bronchiseptica, and G. parasuis. It has been determined that the pneumonia microbiome in growing pigs is represented by a co-infection of 3-6 microorganisms, while in fattening pigs, it consists of 4-7 microorganisms. The maximum number of microorganisms in the pneumonia focus in both groups comprises 9 taxa. Some cases have been identified where none of the microorganisms were detected. The most prevalent microorganisms causing pig pneumonia are PCV2, G. parasuis, S. suis, M. hyorhinis, and P. multocida, whereas the least common are PCV3, PRRSV EU, and SIV type A. There is no evidence of SIV type D circulation among domestic pigs in Ukraine. There was found out the association for verified pneumonia events of growing pigs with dominant viruses PCV2 and PRRSV UA while an average concentration ranging from 108 to 109 genome equivalents per gram of lung tissue. In fattening pigs, PCV2 and A. pleuropneumoniae are most prevalent, with their average quantity varying from 107 to 109 genome equivalents per gram of lung tissue. PCV2 in most pneumonia cases appeared as a monoviral infection. Viral co-infections were identified involving PCV2, PRRSV UA, and PCV3. The least common respiratory virus is SIV type A, detected in only 2% of affected lungs. Bacterial pneumonia without viral involvement in growing pigs is significantly less common than in fattening pigs, but the bacterial spectrum is common for both groups, represented by M. hyorhinis, S. suis, and G. parasuis.
The content of some sexual hormones in the blood of female dogs with different temperament traits
Authors: Forkun V. I. , Bobrytska O. M. , Ugai K. D. , Vodopianova L. A. , Zhukova I. O. , Denisova O. M. , Levchenko A. G.
Published: February 2025

The article provides a theoretical generalization and a new solution to a scientific problem, which is revealed in new scientific data on the dynamics of the content of sexual hormones in the blood plasma of bull terrier female during the sexual cycle. For the first time, the degree and nature of the influence of the individual characteristics of the body of female dogs (characteristics of temperament) on the dynamics of the level of sexual hormones in the blood were established. It was determined that a high degree of manifestation of fear and anxiety in female dogs reliably affects the content of follicle-stimulating hormone (FSH), estradiol (E2) and luteinizing hormone (LH) in the blood plasma of female dogs three days before the LH surge (P≤0.05) and in the phase of anestrus on LH content (P≤0.05). Thus, the level of FSH in the blood plasma of female dogs with a moderate and high degree of fear and anxiety three days before the LH surge and on the 23rd–30th day after the surge is lower by 24.8–30.5% (P≤0.05) compared to the female dogs of the control group. On 120–150 days after the LH surge in female dogs with excessive and moderate fear and anxiety, the LH level is 30.5–39.4% (P≤0.05) lower than that in control animals. The level of excitability of female dogs had a significant effect on the content of FSH and LH levels on the day of the LH surge (P≤0.05). Thus, the level of FSH in female dogs with a high and medium degree of excitability was lower by 29.4–44.5% (P≤0.05), and the content of LH was higher by 53.0% (P≤0.01) than the indicators of female dogs in the control group. The degree of aggression has a significant effect on LH content two days after the LH surge (P≤0.05). In animals with a high degree of manifestation of aggression, the level of E2 in blood plasma at the stage of anestrus is 11.6% higher (P≤0.05), in accordance with the indicators of female dogs of the control group. Trainability and obedience limit the content of FSH in the blood plasma the day before the surge, and on the 4th, 9th and 35–40th days after the LH surge (ħ²ᵪ=0.30–0.52; P≤0, 05). Thus, on the day before the LH surge, the level of FSH in the blood of female dogs with high trainability is 22.7–31.6% (P≤0.05) lower than that of female dogs with medium and low trainability. The LH content in blood plasma, trainability and obedience are affected only on the 9th day after the LH surge (P≤0.01). Consequently, on the 9th days after the LH surge, the level of this hormone in the blood of female dogs with low learning ability is 54.9% (P≤0.01) higher than this parameter in female dogs of the control group.
Humic substance application improves haematological indices of dog’s patients with myxomatous mitral valve disease
Authors: Rimskyi V. V. , Nedzvetsky V. S.
Published: February 2025

Endocardiosis of the mitral valve is one of the most common heart diseases in small breed dogs. The first clinical symptoms, namely cough and inability to bear exercise, appear 3-4 years after the first damage to the valvular apparatus. Symptoms of a stagnant heart failure are due to the presence of regurgitation, which over time leads to an increase in the volume of the left atrium and, as a result, an increase in blood pressure in the pulmonary veins. Due to hypoxia and damage to the myocardium, a significant amount of reactive oxygen species and inflammatory markers are released into the blood, which negatively affect the processes of lipid peroxidation, which leads to a deterioration of the body's antioxidant protection. The results of present study have shown the changes in clinical blood analysis indices for mitral valve endocarditis when adding humic substances to the main protocol of therapy. For research, we selected 12 dogs with mitral valve endocardiosis in stage C according to the classification of the American College of Veterinary Internal Medicine (ACVIM). Confirmation of the pathology was carried out with the use of echocardiography together with complex diagnostics. The animals were conditionally divided into 2 experimental (ST and ST+H) and 1 control group. In addition to the standard therapy of this disease, the drug "Humilid 1%" was added to the diet of the ST+H group during 21 day at the proportion of 10 mg/kg of the active substance once a day. Blood was collected from animals of all groups at the beginning and on the 21st day of the study. The results of clinical blood analysis showed that the addition of substances based on humic compounds to standard therapy increases the total number of erythrocytes in the circulating peripheral blood by 8% and increases the level of haemoglobin and haematocrit by 10.8% and 1.8% (р > 0.05) respectively. The total level of platelets in the ST group significantly increased by 23% (p < 0.04), although in the ST+H group, on the contrary, it decreased by 7% (p > 0.05), but it did not exceed the reference norms in neither group. During the 21 days of the study, the total level of leukocytes did not change in all groups. In the ST+H group, it was found that the absolute number of monocytes was higher than the reference values of 0.9 ± 0.3 109/L on the first day of the study and significantly decreased to 0.4 ± 0.2 109/L (р > 0.05) on the 21st day of administering of “Humilid 1%". Positive changes in leukocyte indices were also detected, which indicates the positive effect of humic compounds on reducing the aseptic inflammatory process, as a complication of mitral valve endocardiosis. In the future, it is planned to study the effect of humic substances on the antioxidant/prooxidant balance of the dog, as well as to study their expected protective potential on the functioning of internal organs affected with myxomatous degeneration of the mitral valve.
Argumentation of the complex scheme for diagnosis and treatment of mastopathy in dogs
Authors: Khomutenko V. L. , Bilyi D. D.
Published: February 2025

Over the past 3 years, a 1.7-fold increase in the incidence of cystic fibrosis in bitches has been recorded. Currently, the problems of early diagnosis of mastopathy and effective treatment of mastopathy, which is one of the ways to reduce the incidence of mammary gland tumors in bitches, have become particularly relevant. The purpose of the research was the development and clinical approval of schemes for complex diagnosis and treatment of bitches with mastopathy. The clinical significance and relationship of the diagnostic criteria for mastopathy in bitches was determined, which became the basis for the substantiation of the diagnostic protocol of fibrocystic disease, which includes a step-by-step analysis of anamnestic data, the results of clinical, ultrasonographic, radiological, histological / cytological research, as well as an assessment of hormonal status and level expression of tumor markers. At the same time, the level of mammary gland tumor markers (carcinoembryonic - CEA and cancer antigen - CA 15-3) makes it possible to exclude the presence of benign and/or malignant neoplasia in other mammary glands. In the absolute majority of cases, nonproliferative histological type (80%) and diffuse form (88.3%) of mastopathy are diagnosed. Among the accompanying diseases, 60.3% have pathologies of the reproductive tract, 18.8% - kidneys and urinary tracts, 12.5% - digestive organs. The clinical feasibility of including Metformin in the therapeutic protocol (Tamoxifen, Dostinex, Indole 3-carbinol OS, Vobenzym, Hepavi-kel) is confirmed by a 9% increase in the effectiveness of treatment against the background of speeding up the recovery period, reducing the risk of further progression and lengthening the period before its onset. The proposed scheme ensured the restoration of follicle-stimulating hormone, progesterone, extradiol and prolactin levels after 4 weeks, while in animals of the control group - only after 8 weeks. The prospect of further research is a more detailed study of the possibilities of using the proposed protocol in oncology practice.
The content modulation of total protein and its fractions in sows with different autonomic nervous system tones
Authors: Danchuk V. O. , Karpovskyi V. I. , Levchenko A. Н. , Karpovskyi P. V. , Chuhno V. S. , Danchuk O. V.
Published: February 2025

The autonomic nervous system plays a key role in the processes of adaptation to changes in the environment. Besides, the sympathetic nervous system is potent to mobilize the resources of organism against to stress factors, while the parasympathetic part carries out the current regulation of physiological functions. The experiment was conducted with use the sows of a large white breed with different tone of the autonomic nervous system. Blood samples were tested for measuring the content of total protein, albumins, globulins and their fractions. The reciprocal interaction of the autonomic nervous system tone with the content of total protein, the indicator of the protein coefficient and the share of albumins and globulins in the blood of sows was established (F= 12.3–14.5 > FU=3.26; P < 0.001). The predominance of the sympathetic tone of the autonomic nervous system in sows has a significant effect on the content of total protein in the blood plasma one day and five days after farrowing (ħ²ᵪ=0.47–0.71; P < 0.05–0.001), while the predominance of the parasympathetic nervous system affects the content of total protein in the blood only five days after farrowing (ħ²ᵪ=0.59; P < 0.01). A reliable influence of the tone of the autonomic nervous system on the share of albumins, globulins and their ratio ten and one days before farrowing in vagotonic sows was established (ħ²ᵪ=0.49–0.59; P < 0.05). The influence of the tone of the autonomic nervous system in vagotonic sows on the share of α-globulins ten days before and one day before farrowing (г²ᵪ=0.58–0.73; Р < 0.01), β-globulins – one day before farrowing (г²ᵪ =0.42; Р < 0.05) and γ-globulins - ten days after farrowing (г²ᵪ=0.40; Р < 0.05). In sympathicotonic sows, the influence of the tone of the autonomic nervous system on the fractions of α-β- and γ-globulins was revealed one day before farrowing (ħ²ᵪ=0.45–0.47; P < 0.05). Ten days before farrowing, the proportion of albumins in vagotonic sows is higher (P < 0.05), and globulins, in particular α-globulins, are lower (P < 0.05-0.001) than in normotonic sows. The content of total protein in the blood of vagotonic and sympathicotonic sows five days after farrowing by 7.9–9.3% (Р < 0.05–0.01), and the content of γ-globulins in the blood of vagotonic sows by 19 .8% (Р < 0.05) less than that in normotonic pigs. The degree and nature of the influence of the tone of the autonomic nervous system of sows on the content of total protein and its fractions in their blood was established.