bluuebunny/crossref_metadata_2025 huggingface dataset:
Imaging Voltage in Genetically Defined Neuronal Subpopulations with a Cre Recombinase-Targeted Hybrid Voltage Sensor
Authors: Bayguinov Peter O. , Ma Yihe , Gao Yu , Zhao Xinyu , Jackson Meyer B.
Published: August 2017

Genetically encoded voltage indicators create an opportunity to monitor electrical activity in defined sets of neurons as they participate in the complex patterns of coordinated electrical activity that underlie nervous system function. Taking full advantage of genetically encoded voltage indicators requires a generalized strategy for targeting the probe to genetically defined populations of cells. To this end, we have generated a mouse line with an optimized hybrid voltage sensor (hVOS) probe within a locus designed for efficient Cre recombinase-dependent expression. Crossing this mouse with Cre drivers generated double transgenics expressing hVOS probe in GABAergic, parvalbumin, and calretinin interneurons, as well as hilar mossy cells, new adult-born neurons, and recently active neurons. In each case, imaging in brain slices from male or female animals revealed electrically evoked optical signals from multiple individual neurons in single trials. These imaging experiments revealed action potentials, dynamic aspects of dendritic integration, and trial-to-trial fluctuations in response latency. The rapid time response of hVOS imaging revealed action potentials with high temporal fidelity, and enabled accurate measurements of spike half-widths characteristic of each cell type. Simultaneous recording of rapid voltage changes in multiple neurons with a common genetic signature offers a powerful approach to the study of neural circuit function and the investigation of how neural networks encode, process, and store information.

SIGNIFICANCE STATEMENTGenetically encoded voltage indicators hold great promise in the study of neural circuitry, but realizing their full potential depends on targeting the sensor to distinct cell types. Here we present a new mouse line that expresses a hybrid optical voltage sensor under the control of Cre recombinase. Crossing this line with Cre drivers generated double-transgenic mice, which express this sensor in targeted cell types. In brain slices from these animals, single-trial hybrid optical voltage sensor recordings revealed voltage changes with submillisecond resolution in multiple neurons simultaneously. This imaging tool will allow for the study of the emergent properties of neural circuits and permit experimental tests of the roles of specific types of neurons in complex circuit activity.
Anti-Debussyism and the Formation of French Neoclassicism
Authors: Wheeldon Marianne
Published: August 2017

Much of the literature on neoclassicism in music focuses on Stravinsky or on the Stravinsky-Schoenberg polemic that emerged in the mid-1920s. Yet both approaches to neoclassicism bypass a crucial moment in its early formation: the former neglects Stravinsky's engagement with the musical priorities of postwar Paris, while the latter ignores the fact that many of the themes that would later crystallize under the banner of neoclassicism were first developed in opposition not to Schoenberg's music but to Debussy's. As described by Jacques Rivière in a letter to Stravinsky of 1919, the postwar musical climate was “anti-impressionist, anti-symbolist, and anti-Debussyist.” This article revisits the debates that appeared in the Parisian musical press between 1919 and 1923, a period in which the term “neoclassicism” had not yet been coined but in which a new, anti-Debussyist aesthetic was nevertheless emerging. Recognizing the role of anti-Debussyism in the formation of neoclassicism is necessary if we are to understand the motivation behind the movement, a motivation that was responsible for establishing its compositional priorities, instrumentation, and aesthetic. Regardless of what neoclassicism later came to represent—be it a return to counterpoint, to Bach, or to the eighteenth century—its initial impetus was much more straightforward. Rather than looking to pre-Romantic traditions, its beginnings were to be found closer to home, going no further back than the reaction against Debussy, Debussyism, and the prewar generation.
Perceived Value of eHealth among People Living with Multimorbidity: A Qualitative Study
Authors: Runz-Jørgensen Sidsel M. , Schiøtz Michaela L. , Christensen Ulla
Published: August 2017

Background

The prevalence of multimorbidity is increasing, creating challenges for patients, healthcare professionals, and healthcare systems. Given that chronic disease management increasingly involves eHealth, it is useful to assess its perceived value among people with multimorbidity.

Objective

To explore challenges related to multimorbidity and patients’ perspectives on eHealth.

Design

Ten semi-structured interviews with adults, living with multimorbidity in Copenhagen, Denmark. Interviews focused on patient-experienced challenges, from challenges related to self-management to challenges experienced in the healthcare sector, as well as perceptions of eHealth. During interviews, participants were presented with pictures of different eHealth technologies. Data analysis followed the systematic text condensation approach.

Results

Participants experienced challenges in their daily lives, e.g. when practicing self-management activities, when navigating the healthcare sector, and when interacting with healthcare professionals. Patient-perceived value of eHealth varied, depending on their burden of illness and treatment: those with a greater burden had more positive perceptions of eHealth, and expressed more intention to use it. Participants with less complex disease patterns and less burdensome treatment regimens were more likely to perceive eHealth as something worthless and undesirable. Participants stressed that eHealth should only be introduced as an optional supplement.

Conclusions

eHealth can potentially address some patient-experienced challenges related to multimorbidity by promoting self-management, patient-centeredness, and access. However, patients’ needs and preferences vary and eHealth cannot substitute the personal interaction between patient and healthcare professionals. Our findings point to the importance of patient assessment and stratification to ensure appropriate use of eHealth.
Etički pogled na demokraciju Karola Wojtyle
Authors: Tičac Iris
Published: August 2017

Nakana je ovog rada predstaviti etički pogled na demokraciju Karola Wojtyle - pape Ivana Pavla II. kao aktualan i značajan doprinos obrani demokracije na njenim izvorima. Budući da govor o demokraciji pretpostavlja govor o čovjeku ponajprije se osvjetljuje Wojtylin personalizam kao ishodište za promišljanje smisla demokracije. Wojtylin filozofijski prinos promišljanju smisla demokracije prepoznaje se već u odlučnoj kritici antipersonalistickih koncepcija koje leže u temelju individualizma i kolektivizma, u njegovoj razradi načela "sudjelovanja" kao autentičnog temelja ljudske zajednice, u personalističkoj i teleološkoj koncepciji "zajedničkog dobra", a posebice u isticanju temeljnih načela i fundamentalnih vrijednosti (istine o čovjeku, ispravno shvaćene slobode), bez kojih nije moguće izgraditi autentičnu demokraciju.
Genetic Screen for Postembryonic Development in the Zebrafish (Danio rerio): Dominant Mutations Affecting Adult Form
Authors: Henke Katrin , Daane Jacob M , Hawkins M Brent , Dooley Christopher M , Busch-Nentwich Elisabeth M , Stemple Derek L , Harris Matthew P
Published: August 2017

Large-scale forward genetic screens have been instrumental for identifying genes that regulate development, homeostasis, and regeneration, as well as the mechanisms of disease. The zebrafish, Danio rerio, is an established genetic and developmental model used in genetic screens to uncover genes necessary for early development. However, the regulation of postembryonic development has received less attention as these screens are more labor intensive and require extensive resources. The lack of systematic interrogation of late development leaves large aspects of the genetic regulation of adult form and physiology unresolved. To understand the genetic control of postembryonic development, we performed a dominant screen for phenotypes affecting the adult zebrafish. In our screen, we identified 72 adult viable mutants showing changes in the shape of the skeleton as well as defects in pigmentation. For efficient mapping of these mutants and mutation identification, we devised a new mapping strategy based on identification of mutant-specific haplotypes. Using this method in combination with a candidate gene approach, we were able to identify linked mutations for 22 out of 25 mutants analyzed. Broadly, our mutational analysis suggests that there are key genes and pathways associated with late development. Many of these pathways are shared with humans and are affected in various disease conditions, suggesting constraint in the genetic pathways that can lead to change in adult form. Taken together, these results show that dominant screens are a feasible and productive means to identify mutations that can further our understanding of gene function during postembryonic development and in disease.
La educación rural: un camino de lastre en un mundo de autopistas
Authors: Rugama López Bryan
Published: August 2017

Este ensayo tiene como objetivo poner en perspectiva algunas de las situaciones que enfrenta la educación en las zonas rurales en Costa Rica, en torno a las prácticas educativas que se desarrollan, ya que estas difieren en comparación con algunos centros de estudio del área metropolitana. Las zonas rurales claman por ver la luz en temas de educación, sociedad y políticas educativas.
Microstructural factors affecting the static and the cyclic resistance of a pyroclastic silty sand
Authors: Licata V. , D'Onofrio A. , Silvestri F.
Published: August 2017

In this note the undrained cyclic behaviour of a pyroclastic silty sand typical of the Neapolitan area, in southern Italy, is analysed through an extensive laboratory investigation. Monotonic and cyclic triaxial tests were carried out on undisturbed samples and on reconstituted soil mixtures. The latter were prepared keeping the grain size distribution of the natural soil as reference and replacing either non-plastic ash with a plastic fine (PCR) or the pyroclastic sandy fraction with a siliceous material (SAR). All the tests were carried out at the same consolidation relative density and confining stress with the purpose of studying the influence of peculiar constitutive factors, such as fabric, particle breakage and non-plastic fines content on the undrained cyclic behaviour. The results highlight that the structure significantly enhances the liquefaction resistance of the natural material with respect to that of reconstituted samples. Furthermore, the non-plastic fine ash was observed to increase the cyclic resistance of the pumice sand with respect to that of the same coarse matrix with added plastic fines. Finally, no appreciable evidence of grain crushing was detected in any of the tested soils containing pyroclastic sand.
LA TRAMITACIÓN SUBJETIVA DE LA INTOLERANCIA EN UNA EXPERIENCIA DE GRUPO DE ACONTECIMIENTO
Authors: Orozco Guzmán Mario , Gamboa Solís Flor de María , Pavón-Cuéllar David
Published: August 2017

Se propone una modalidad de intervención clínico-grupal denominada “Grupo de Acontecimiento” para el tratamiento de situaciones de intolerancia. El procesamiento de este tipo de experiencias implica un trabajo de reescritura para la integración simbólica de las mismas. La vivencia de intolerancia pasa por la palabra y significación comprometida de los otros. Los testimonios exponen la variación interpretativa de los discursos y la repercusión del acontecimiento como impresión decisiva y trascendental en la historia de un sujeto. La modificación testimonial responde a la escucha y lectura que los otros desplieguen de los sentidos que se anuden a la escritura del acontecimiento.
Catalog, nomenclatural acts and distribution of Scarabaeinae (Coleoptera, Scarabaeidae) from Ecuador v1
Authors: Chamorro William , Marin-Armijos Diego , Z. Vaz-De-Mello Fernando
Published: August 2017

The Ecuadorian territory is divided into four natural regions: the coastal lowlands, the Andean highlands, the Amazon basin and the Galapagos Islands. Each of these regions has its own ecosystems and specific vegetation. The purpose of this work is to compile an updated catalog of the Scarabaeinae (Coleoptera: Scarabaeidae) of Ecuador that includes distributional data and several nomenclatural acts. Data was compiled from 26 scientific collections, with the examination of 13550 scarabaeines; additionally 368 bibliographic references were reviewed for the taxonomic historic. The Scarabaeinae fauna from Ecuador contain 33 genera and 217 species, with 45 restricted (endemic) species and eight records erroneously attributed. The following taxonomic findings were reported, three new status: Canthon (Glaphyrocanthon) ohausi Balthasar, 1939 stat. n; Deltochilum (Calhyboma) arrowi Paulian, 1939 stat. n; and Dichotomius (Dichotomius) angustus (Luederwaldt, 1923) stat. n; four new synonyms: Deltochilum (Deltohyboma) aureopilosum Paulian, 1938 syn. n; Dichotomius (Dichotomius) provisorius Luederwaldt, 1925 syn. n; Dichotomius (Dichotomius) hempeli Pereira, 1942 syn. n; and Uroxys magnus Balthasar, 1940 syn. n; six revalidated taxa are established: Canthidium (Eucanthidium) orbiculatum (Lucas, 1859); Coprophanaeus (Coprophanaeus) edmondsi Arnaud, 1997; Coprophanaeus (Coprophanaeus) florenti Arnaud, 2002; Dichotomius (Luederwaldtinia) fortepunctatus (Luederwaldt, 1923); Phanaeus (Notiophanaeus) pyrois funereus Balthasar, 1939; Phanaeus (Notiophanaeus) viridicollis Arnaud, 2002; Canthon (Glaphyrocanthon) subhyalinoides Balthasar, 1939, as revised status; Uroxys ohausi (Balthasar, 1938), as comb. n, and 69 new lectotypes are designated. Photographs of some type specimens are included and maps of geographical distribution of each species are provided.
Experience medical rehabilitation of the patient after a comprehensive treatment of medulloblastoma of cerebellum with metastases in the shell and the substance of the spinal cord
Authors: Danilenko Larisa A , Belogurova Margarita B , Gayduk Alexander A
Published: August 2017

The article describes the experience of medical rehabilitation of patients after a complex treatment of cerebellar medulloblastoma with metastases in the spinal cord membranes and substance. Substantiates the role of medical rehabilitation funds in correcting the effects of the disease, and cancer treatment, the essence of which is determined by the damage to the structure and function of various organs and systems. The most common effects of the three-treating medulloblastoma are postoperative deficits: ataxia and paresis; radiation myelopathy, polyneuropathy chemotherapy-induced, deformations of the skeletal system, reduced functional performance and adaptation. Actualized value of interdisciplinary interaction: oncologists, pediatricians, neurologists, orthopedists, medical rehabilitation specialists; phasing and integrated use of all available methods of rehabilitation. Presented personalized rehabilitation program to study techniques of individual lessons therapeutic exercises, therapeutic swimming, gidrokinezioterapii, procedures, motor praxis, training paretic muscles of the selected feedback, massage. It is shown that multimodal rehabilitation treatment of patients at high risk of being in remission, is effective in its action in assessing both subjective: improvement of health, emotional tone, sleep, increased appetite, and objective data: normalization of body weight, improving coordination and increasing the range of motion, increase muscle strength, strength endurance muscle corset. Currently, medical rehabilitation is an essential component of cancer patients routing.
Features of morphological changes of the liver’s tissue in cases of sudden cardiac death because of alcoholic cardiomyopathy
Authors: Sokolova Olga V , Nasyrov Ruslan A
Published: August 2017

A retrospective analysis of acts of forensic autopsies from the archives of St Petersburg GBOOSE BSME and histological examination of liver tissue in an amount of 152 cases (78 women and 74 men) with a statistical processing of the results for studying and evaluating the morphological changes of liver’s tissue in cases of sudden cardiac death from alcohol cardiomyopathy. Identified in the course of the study morphological changes in the endothelial lining of the microvasculature showed that in addition to direct cytotoxic effects of ethanol and its metabolites in the basis of damage to the endothelial lining of the microvasculature are the cellular responses associated with exposure to mediators, the release of which is due to irritation of reactive cells, which entails a swelling deformation and increased activity endothelial cell membranes with the expansion of intercellular spaces. The development of increased permeability of the endothelial lining of transport contributes to a violation of electrolytes and nutrients to the changes of the liver’s tissue trophism, which is a substrate for the occurrence of degenerative processes and necrobiotic major structural components of the body. In turn, a direct toxic effect of ethanol and its metabolites on the wall microvascular contributes to ischemia and necrosis of the hepatocytes with the development of severe inflammatory reactions in the surrounding liver tissue, which in turn is the direct cause of the disturbances regeneration nature and excessive proliferation connective tissue with the subsequent restructuring of the vascular bed. Identified and described the morphological criteria of changes in liver’s tissue in cases of death from alcoholic cardiomyopathy should be considered in conjunction with other visceral manifestations, being a reflection of the alcohol intoxication in chronic alcoholism.
Possible ways of decline of infantile death rate are in the separate regions of Russian Federation
Authors: Telesh Olga V , Petrenko Yuriy V , Ivanov Dmitry O
Published: August 2017

This article considers the level of infant mortality - one of the most important criterion of “demographic prosperity “in the state. Here is brief historical characterization of demographic processes since the end of 20th century till the present in Russia. Nowadays, the level of infant mortality in Russia much higher than in most European countries. Information about the factors that affect the level of infant mortality and which ones can be controlled will help to understand why infant mortality levels are so different in Russia, European countries and USA for example. First factor is direct causes of infant mortality, the second one is medical care system responsible for pregnant women and children. Today causes of neonatal mortality and ways of eliminating these causes are analyzed. Countries with low level of infant mortality have a successful three-tier model of perinatal care. Russia is also undergoing modernization care system for children and pregnant women and the transition to a three-tier system of assistance. The main objective of the three-tier system is the direction of women in high-risk groups in the establishment of the level that has the capacity to provide them with necessary assistance. Three-tier system in different regions of Russia have different features so we have various coefficients of infant mortality. Some regions have high rates; some ones have similar level to the European countries. Such differences lead to the conclusion that we need to develop regional patterns of medical care which will take into account the specificities of each region.
Role of TaqI-Genetic Polymorphism of Vitamin D Receptor Gene in Bone Metabolism in Children with Inflammatory Bowel Disease
Authors: Gabrusskaia Tatiana V , Kostik Michail M , Nasyhova Yulia A , Revnova Maria O , Kuzmina Diana A
Published: August 2017

Evaluation of bone mineralization and bone metabolism in children with inflammatory bowel disease (IBD) in accordance with TaqI-polymorphic genotypes of vitamin D receptor (VDR) has been performed in this study. 83 children (38 girls and 54 boys) with IBD (60 with Crohn’s disease, 23 with ulcerative colitis) have been included in the study. Mean age was 13.0 years (11.0; 15.5). All patients have active phase of the disease. Bone mineral density (BMD) of lumbar spine (DEXA) have been assessed in all children. Level of serum osteocalcin (OC) as a marker of osteosynthesis, C-terminal telopeptides (CTT) as a marker of osteoresorbtion, parathyroid hormone (PTH), serum calcium, phosphorus, alkaline phosphatase and 25(OH) vitamin D was measured to evaluate bone metabolism. Molecular-genetic tests: analysis of TaqI (rs731236) polymorphism of vitamin D receptor gene (VDR) was perfomed by polymerase chain reaction with following restriction analysis. Association between molecular markers of VDR gene and bone metabolism and mineralization disturbances have been found. TT genotype of VDR gene was associated with tendency to decrease of linear growth velocity, low linear growth, decrease in osteosynthesis and increase of osteoresorbtion in this group of children. TT-genotype of TaqI-polymorphism of VDR gene can be assessed as a risk factor of bone metabolism disturbances in children with both Crohn’s disease and ulcerative colitis. C allele seems to have protective role in this group.
Risk factors, predictors and contemporary diagnostics of bronchopulmonary dysplasia
Authors: Prometnoy Dmitry V , Alexandrovich Yuri S , Voronenko Irina I
Published: August 2017

Improving of resuscitation and intensive care of premature babies allowed their survival. Bronchopulmonary dysplasia (BPD) is the significant complication of low-birth newborns. Identification of early predictors of disease can optimize of treatment and decrease of quantity of appearance and severity of BPD. Quantity of BPD is 5-97%. The significant predictors from hereditary and genetic factors are family bronchopulmonary pathology, dysplasia of connective tissue, gene polymorphism of VEGF, EPNX-113 Hiss, Nos3-786C, GCLC, 58 Т/С sod2, minore allele - 460 of T-gene (VEGF); from clinical and immunological factors - lung immaturity, alveolarization and vascularization disorders, hemodynamically significant ductus arteriosus; from biochemical factors - hyperoxy, lipid peroxidation and decreasing of antiperoxidation, disorder of angiotensin-1/endostatin; from therapeutic factors - overexertion of lungs during ventilation, avoiding of antiperoxid protection, insufficiency of nutrition. Contemporary methods of BPD diagnostic are clinical data (oxygen dependence at 28 days after birth), X-ray sings, identified by X-ray examination and tomography and bronchophonography. More of identified factors and predictors of BPD are difficult for examinations, haven’t 100% result or low predictive power, that is why further study is needed.
Intellectual characteristics of adolescents with chronic gastroduodenitis
Authors: Gurova Margarita M , Uspenskiy Yury P
Published: August 2017

Intellect is one of the indicators of children’s health, characterizing the optimality of the age development and the success of adaptation processes. In the case-control study, were included 60 adolescents with chronic gastroduodenitis (CGD) in the period of remission (main group), average age – 13 years old. The comparison group consisted of 22 children with the I group of health. A comparative evaluation of the features of the course of the antenatal period, childbirth, and features of early development of the child was carried out. Were estimated the indicators of stress level, social adaptation (M. Gavlinova’s questionnaire), intellectual functions (D. Veksler’s test). It was shown that the total index reflecting the level of stress in children of the main group was 173.03 ± 82.69 points compared to the index of children of the comparison group – 96.34 ± 38.5 points (p < 0.01). In the main group, compared with the control, children with low level of adaptability were more likely to meet, less often children with an average level of adaptation (34.8% / 21, CI 27.4-41.4% vs 55.3% / 12, CI 42, 32-63,28, р < 0,05) and there were no children with a high level of adaptation. In children with CGD, Veksler’s WISC method (for children 5-16 years of age) showed a slight decrease level of verbal, non-verbal and total IQ in comparison with healthy peers. Among the risk factors that affect intellectual status, the most important were the burdened perinatal history, the nature of feeding in the first year of life and the unbalanced diet in subsequent periods of life.
Operation on Billroth-I in gastric cancer surgery: the evolution of views
Authors: Morgoshiia Temuri Sh
Published: August 2017

In recent years almost all over the world, there is a decrease in the incidence of gastric cancer. Despite that carcinoma of the stomach annually affects on our planet about 1 million people. The prevalence of distal gastric cancer has a tendency to decrease, while the frequency of proximal cancer increases slightly. Early gastric cancer is only 10% of all new cases, and in 64,2% of patients are diagnosed at stages III-IV disease. Over the last 35 years, there has been substantial progress in the diagnosis and treatment of gastric cancer. Surgery that involves complete removal of the tumor remains the only method which gives hope for cure of the patient, despite the significant number of combined and complex treatment methods of this disease. However, many provisions of this concept have changed drastically. After surgery Billroth-I much less frequently and with less severity (than after resection Billroth-II) develops duodenogastric reflux in the absence of duodenostasis and adequate patency of the digestive tract. It is the reflux of bile and pancreatic juice plays an important role in the occurrence of cancer of the stomach stump. The basic cause of cancer is the development of atrophic gastritis as a consequence of denervation of the authority and the reflux of bile into the resected stomach. The choice of the method of restoring the integrity of digestive tract after distal gastrectomy is a topical problem, given the continuous increase in the number of patients undergoing this operation. In the review of literature shows that intervention in the modification of the Billroth-I does not increase the number of postoperative complications, no differences in long-term results of surgical treatment of gastric cancer for two methods of restoring the continuity of the digestive tract after distal resection.
Hemodynamic Patterns Determined By Non-Invasive Cw-Doppler Ultrasound Cardiac Monitoring (USCOM) in Preterm Neonates with Respiratory Distress Syndrome During Non-Invasive Respiratory Support
Authors: Sergeeva Vera A. , Alexandrovich Yuri S. , Strelkov Denis M. , Siniuk Kseniya A.
Published: August 2017

Aim: To determine the hemodynamic patterns in preterm neonates with respiratory distress syndrome (RDS) using the USCOM-1A technology.

Materials and Methods: The USCOM device is a bedside method of evaluating cardiac output (CO) based on continuous-wave Doppler ultrasound. Hemodynamic parameters were measured daily for 7 days in 32 preterm neonates 32 ± 1 weeks of gestation (1688 ± 111 g) with RDS requiring noninvasive respiratory support (NCPAP, NIPPV, HFNC) and no catecholamine support in comparison with 28 healthy term neonates (3100 ± 690 g).

Results: At day 1, preterm neonates had lower SVI (18 ± 5 vs 28 ± 8 ml m-2, p = 0.043) and higher SVRI (1585 ± 245 vs 1035 ± 358 dyn s cm-5 m2, p = 0.013) with a tendency for lower cardiac index (2.6 ± 0.8 vs 4.0 ± 1.3 l min-1 m-2, p = 0.089). Together with no difference in SMII, it indicates the presence of diastolic dysfunction with low preload. It is noted that all parameters had not changed by day 7 in preterm neonates, whereas term neonates demonstrated significantly increased SMII reflecting postnatal cardiovascular adaptation. Compared with preterm neonates with RDS requiring NCPAP/NIPPV, preterm neonates requiring HFNC had higher levels of FTc (330 ± 59 vs 388 ± 41 ms, р = 0.045), SVI (13 ± 3 vs 18 ± 4, ml/m2, р = 0.007), SMII (0.41 ± 0.09 vs 0.57 ± 0.21, р = 0.02), and CI (2.2 ± 0.6 vs 4.5 ± 0.9 l/min/m2, р = 0.006).

Conclusions:Noninvasive respiratory support in preterm neonates with RDS may lead to diastolic dysfunction that is less prominent in neonates with HFNC.
Lesion of the mucous membrane of the stomach, caused by chlamydia in children with chronic glomerulonephritis
Authors: Chikulaeva Elena V , Melnikova Valentina F , Nasyrov Ruslan A
Published: August 2017

We studied biopsies of gastric mucosa and the gastric antrum bodies obtained from 60 children with chronic gastritis and chronic gastritis in combination with chronic glomerulonephritis. Clinical data of patients (age, gender, duration of the underlying disease, conducted therapy, the results of laboratory and instrumental studies) were studied. It conducts research using histological and immunohistochemical methods. A morphological study of the sections found gastrobiopsies characteristic manifestations of chronic gastritis c signs of chlamydial lesions. The immunohistochemical method determined Chlamidia trachomatis antigens in the antrum and corpus. The positive expression in the epithelial cells of glands and endothelial microvascular gastric mucosa with concomitant lesions of the stomach and kidneys. The possibility of the development of chronic gastritis chlamydial infection in chronic glomerulonephritis. Based on the obtained results was made comprehensive assessment of the gastric mucosa based on morphological, immunohistochemical and clinical data. The features of stromal-vascular responses in the development of chronic gastritis occurring in isolation and combined with chronic glomerulonephritis. The effect of steroid therapy, as a cause of decrease in protective mechanisms of gastric mucosa in children. The data supporting the need for immunohistochemical studies for the etiologic diagnosis of chronic gastritis and the subsequent selection of appropriate therapy.
Anomalies of the Constitution and Tuberculosis Infection in Children
Authors: Yarovaya Iulia A , Lozovskaya Marina E , Vasilieva Elena B , Klochkova Ludmila V , Noskova Olga M , Bikova Irina A
Published: August 2017

Phenotypical implications of genetic features are anomalies of the constitution or diathesis. A research objective children had an identification with a tuberculosis infection of occurrence of diathesis. 222 children aged from 1 year up to 14 years are examined: 106 children with active forms of tuberculosis; 54 children with residual post-tubercular changes; 62 children infected with MBT. Limfatiko-hypoplastic, allergic, neuroarthritic, exudative and catarral diathesis was taped. Children with limfatiko-hypoplastic (17.0 ± 3.7%) and neuroarthritic diathesis most often occur among patients with active tuberculosis (17.0 ± 3.7%), children with allergic diathesis are more rare (10.4 ± 3.0% of cases. The least favorable current of active forms of tuberculosis became perceptible at children with limfatiko-hypoplastic diathesis: the complicated forms of tuberculosis became perceptible at them in 27.8 ± 10.6% of cases. At patients with neuroarthritic diathesis the complicated forms developed less often - in 11.1 ± 7.4% of cases. Children with allergic diathesis transferred only uncomplicated forms of primary period of tuberculosis. At children without anomalies of the constitution the complicated current was observed often - in 27.6 ± 5.9% of cases. Frequency of occurrence of children with allergic diathesis is higher at patients with residual post-tubercular changes (29.6 ± 6.2%) and the infected MBT (33.8 ± 6.1%), than at patients with active tuberculosis (10.4 ± 3.0%). Existence of a certain anomaly of the constitution in many respects predetermines the course of a tuberculosis infection.
The Medical Underwriting of Transgender Individuals
Authors: Meagher Timothy , Filzmaier Karsten
Published: August 2017

As more transgender individuals apply for life insurance, it is important to understand the many health issues that are particular to this population. This article reviews the pathophysiology, diagnosis and treatment of gender dysphoria- the dominant medical problem of transgender individuals. It also reviews the frequent co-morbidities in the transgender population and finishes with a review of the small number of studies that have examined long-term mortality.
Infarction or Pseudo-infarction?
Authors: MacKenzie Ross
Published: August 2017

An applicant with a history of paroxysmal atrial fibrillation is found to have QS waves in leads III and AVF suggestive of a prior inferior wall myocardial infarction. Using the relationship between Q wave and T wave vectors in the inferior leads, an alternative explanation is explored.
Kikuchi Disease
Authors: Williams David S.
Published: August 2017

Kikuchi disease is a rare, idiopathic, self-limited disorder affecting the cervical lymph nodes.
Suicídio e Tentativa de Suicídio: Contribuições da Enfermagem Brasileira
Authors: Soares Raquel Juliana De Oliveira , Nascimento Flaviana Pereira Bastos
Published: August 2017

Considerado um problema de saúde pública, o suicídio vem aumentando mundialmente. É um problema complexo para o qual não existe uma única causa ou razão, e para que a prevenção seja efetiva é preciso que os profissionais da saúde entendam do assunto e saibam reconhecer o comportamento suicida. Neste sentido, foi traçado como objetivo analisar a produção científica da enfermagem brasileira sobre suicídio e tentativa de suicídio no período de 2005 a 2015. Revisão integrativa com análise temática. Observou-se o aumento das publicações sobre suicídio, tentativa de suicídio e adolescente. Homens comentem mais suicídio e as mulheres são mais prevalentes nas tentativas. Enforcamento, intoxicação e arma de fogo são os meios mais utilizados no suicídio e nas tentativas de suicídio. Concluiu-se que existe uma urgência em se trabalhar a prevenção do suicídio baseado nas publicações, uma vez que as mesmas abordam desde o perfil dos suicidas até os métodos utilizados no suicídio e tentativas de suicídio. Palavras-chave: Saúde Pública. Pesquisa em Enfermagem. Revisão.AbstractConsidered a public health problem, suicide is increasing worldwide. It is a complex problem for which there is no single cause or reason, and so that prevention ise effective it is necessary that health professionals understand the issue and know how to recognize suicidal behavior. In this regard it was drawn to analyze the scientific production of Brazilian nursing on suicide and attempted suicide in the period from 2005 to 2015. Integrative review with thematic analysis. There was an increase in publications about suicide, suicide attempt and adolescents. Men commit more suicide and women are more prevalent in attempts. Hanging, poisoning and firearms are the most used means of suicide and the suicide attempts. It was concluded that there is an urgent need to work to prevent suicide based on publications, since the same address not only the suicide’s profile but alsothe methods used in suicide and suicide attempts.Keywords: Public Health. Nursing Research. Review.
Avaliação da Saúde Gengival de Pacientes em Uso de Anticoagulantes
Authors: Silva Leandro Veroneide Pio da , Semenoff Tereza Aparecida Delle Vedove , Granjeiro Claudia Da Fonseca , Borges Álvaro Henrique , Paulino Niraldo , Segundo Alex Semenoff
Published: August 2017

Na atualidade, as questões que envolvem o uso de anticoagulantes com o sangramento gengival aumentado ainda não são bem esclarecidas, havendo necessidade de avaliação se realmente estes medicamentos podem condicionar a mudança na inflamação gengival. Buscou-se neste estudo questionar e avaliar a saúde gengival de indivíduos cardiopatas, que utilizam anticoagulantes em período de internação. Foram aplicados questionários para coleta de dados socioeconômicos dos pacientes cardiopatas internados e realizou-se exame dos índices de placa visível (IPV) e sangramento gengival (ISG). Os pacientes participantes deste estudo eram > 18 anos, com 10 ou mais dentes em boca, cardiopatas internados e usuários de anticoagulantes. Participaram deste estudo 58 pacientes, a média de idade foi 55+12,92 anos; 69% eram homens; 62,1% leucodermas; 20,7% tabagistas e 46,6% diabéticos. O tempo da cardiopatia foi de 57,18+85,69 meses. O retorno ao Dentista ocorreu em média de 83,20 meses; 53,5%, 43,1% e 3,4% pertencem, respectivamente, as classes C, D e B. A maioria dos pacientes (87,9%) teve presença de IPV e 46,6% apresentou ISG. Na análise de risco houve uma relação entre o IPV e tabagismo -1,31 (1,12-1,53); >30 anos 1,085 (1,002-1,176), >40 anos; 1,244 (1,084 – 1,424). Cardiopatas que usam anticoagulantes apresentam necessidades de cuidados em relação à cavidade oral.Palavras-chave: Doença das Coronárias. Boca. Equipe Hospitalar de Odontologia. Gengivite.AbstractNowadays, the issues surrounding the use of anticoagulants such as increased bleeding gums are not well understood yet, there is need to assess whether these drugs actually may make the change in gingival inflammation. We sought to study this question and assess the gingival health of cardiac patients using anticoagulants in hospitalization. Questionnaires were used to collect socioeconomic data from hospitalizedpatients and examination of visible plaque index (VPI) and gingival bleeding (GBI) were carried out. The patients participating in the study were ≥18 years, with 10 or more teeth in their mouth, hospitalized cardiac patients and anticoagulants user. The study included 58 patients, mean age was 55+12,92; 69% were men; 62.1% Caucasian; 20.7% were smokers and 46.6% diabetics. The time of disease was 57,18+85,69 months. The return to the dentist was an average of 83.20 months; 53.5%, 43.1% and 3.4% are respectively the classes C, D and B. Most patients (87.9%) had the presence of IPV and 46.6% had ISG. The risk analysis there was a relationship between VPI and smoking -1.31 (1.12 to 1.53); > 30 years 1.085 (1.002 to 1.176), > 40; 1.244 (1.084 to 1.424).Keywords: Coronary Disease. Mouth. Dental Staff Hospital. Gingivitis.
Rotulagem de Alimentos Infantis à Base de Frutas, Hortaliças e/ou Cereais: uma Análise de Conformidade Frente à Legislação Brasileira
Authors: Silva Mira Balotin Leocadio da , Nomelini Quintiliano Siqueira Schroden , Pascoal Grazieli Benedetti
Published: August 2017

Os hábitos alimentares sofreram transformações ao longo da história da humanidade, tais mudanças trouxeram consequências diretas naalimentação infantil e com o intuito de regulamentar os produtos industrializados destinados a esse público, a ANVISA/MS normatizou arotulagem dos alimentos infantis por meio de diversas Resoluções e Portarias. Desta forma, o objetivo da pesquisa foi analisar a conformidadede rótulos de alimentos infantis à base de frutas, hortaliças e/ou cereais. Os rótulos foram analisados segundo a legislação brasileira: RDCnº 259/02, Lei n° 10.674/03, RDC n° 360/03, Informe Técnico nº 36/08, Portaria n° 34/98, Portaria n° 36/98, RDC n° 222/02 e Decretonº 8.552/2015. Para verificação de conformidade foram elaborados e utilizados checklists baseados nas legislações, acima mencionadas, ea estatistica dos dados consistiu em uma análise descritiva e estimação intervalar. Foram verificados 57 rótulos (20 papinhas, 8 purês, 12sopinhas, 13 cereais para alimentação infantil e 4 alimentos líquidos) e foi observado que 100% (n=57) dos produtos tiveram pelo menos umitem em inconformidade frente à legislação brasileira vigente, sendo que se destacam as seguintes inconformidades: apresentação não adequadada tabela da rotulagem nutricional e não apresentação ou apresentação errada da frase obrigatória. É necessário maior fiscalização por partedos órgãos governamentais quanto ao cumprimento da legislação brasileira vigente, visto que foram observadas diversas inconformidades nosalimentos à base de frutas, hortaliças e/ou cereais destinados ao público infantil.Palavras-chave: Nutrição da Criança. Lactente. Alimentos.
Perfil dos Trabalhadores Motoristas e Fatores para Doenças Cardiovasculares
Authors: Kolhs Marta , De Moraes Vanessa Correa , Figueiro Thamara Hubler , Busnello Grasiele Fatima
Published: August 2017

As doenças cardiovasculares representam um agravo impactante no perfil da população mundial, sendo o gênero masculino um grupo de maior vulnerabilidade. O estudo objetivou verificar o perfil dos trabalhadores motoristas para as doenças cardiovasculares em que estão expostos. Trata-se de uma pesquisa epidemiológica transversal realizada com 22 motoristas de uma empresa de transporte do município de Chapecó (SC). Realizou-se uma entrevista, a fim de obter informações sociodemográficas e fatores de risco, os quais foram tabulados por meio do programa SPSS. Identificou-se prevalência da faixa etária de 40 a 49 anos 59,1%, a grande maioria 59,1% trabalha 12 anos ou mais como motorista. Foi verificado que 40,9% dos motoristas apresentavam níveis pressóricos descontrolados; 54,6% dos motoristas apresentavam préobesidade e 9% destes apresentavam algum grau de obesidade. Considera-se que os motoristas apresentam riscos para o desenvolvimento de doenças cardiovasculares, em função daa profissão possuir particularidades, que dificultam a prática de hábitos saudáveis.Palavras-chave: Doenças Cardiovasculares. Saúde do Homem. Saúde do Trabalhador.AbstractCardiovascular diseases represent an impact on the profile of the world population, being the male a group of greater vulnerability. The objective of this study was to verify the the Driver’ Workers’ profile for the cardiovascular diseases in which they are exposed. This is a crosssectional epidemiological study carried out with 22 drivers from a transport company in the municipality of Chapecó (SC). An interview was carried out in order to obtain sociodemographic information and risk factors, which were tabulated using SPSS. It was identifieda prevalence of the age group 40-49 years (59.1%), the majority 59.1% work 12 years or more as drivers. It was found that 40.9% had uncontrolled blood pressure levels; 54.6% of drivers were overweight and 9% had some degree of obesity. It is considered that drivers are at risk for developing cardiovascular disease, because the profession has conditions which make it difficult to practice healthy habits.Keywords: Cardiovascular Disease. Men’s Health. Occupational Health.
Higienização das Mãos: Adesão dos Profissionais Antes e Após Programa de Capacitação
Authors: Scherer Juliane De Souza , Gleit Patrícia Machado , Negeliskii Christian , Bueno André  Luis Machado
Published: August 2017

Capacitação e educação são essenciais aos profissionais de saúde sobre a importância da higienização das mãos (HM) durante a assistência direta, no intuito de, constantemente, provocar reflexão e o aumento na adesão à HM. Este estudo comparou a taxa de adesão à HM, após uma campanha de capacitação em Centro de Terapia Intensiva Adulto (CTI). Foram comparadas as taxas de adesão de HM verificadas em março e junho de 2012, do CTI Adulto, respectivamente, antes e após a campanha de capacitação realizada pelo Serviço de Controle de Infecção Hospitalar nos meses de abril e maio do mesmo ano. Os resultados apontam uma maior adesão à HM pelos profissionais enfermeiros (67,57%) e fisioterapeutas (72,73%) antes da campanha. Após a campanha de educação, a resposta em relação à higiene correta pelos profissionais da enfermagem aumentou (79,31%), enquanto para os fisioterapeutas houve uma redução (56,25%) na taxa de adesão. Mesmo com todas as evidências convincentes publicadas sobre a importância da adesão à higienização de mãos no combate às infecções, ainda não se atingiu a adesão total à técnica. Portanto, a capacitação específica e periódica influência nos índices de adesão de HM e na melhoria da qualidade da assistência, resultando em maior segurança dos processos assistenciais.Palavras-chave: Desinfecção das Mãos. Controle de Infecções. Educação Continuada. Capacitação em Serviço.AbstractTraining and education are essential for health professionals on the importance of hand hygiene (HM) during direct care, in order to constantly instigate reflection and HM increase adherence. This study compared the HM adherence rate after a training campaign at the Center for Adult Intensive Care (ICU). The HM adherence rates verified in March and June 2012, respectively were compared, before and after the training campaign carried out by the Hospital Infection Control Service in April and May of the same year. The results indicate a higher nurses’ HM adherence (67.57%) and physiotherapists (72.73%) before the campaign. After the education campaign, the response to correct hygiene by nursing professionals increased (79.31%), while for physiotherapists there was a reduction (56.25%) in the adherence rate. Even with all the compelling evidence published on the importance of adherence to hand hygiene in combating infections, complete adherence to the technique has not been achieved yet. Therefore, specific and periodic training influences HM adherence rates and improves the care quality, resulting in greater security of care processes.Keywords: Hand Disinfection. Infection Control.Continuing Education. In-service Training.
Efeitos da Suplementação de Leucina Associada ao Treinamento Resistido Sobre a Força Muscular em Sujeitos Jovens
Authors: Grala Alan Pablo , Teixeira Marcos Antonio Rolim , Nishitani Tatiana Cipriano , Melozi André Fusco , Jacinto Jeferson Lucas , Aguiar Andreo Fernando
Published: August 2017

A proposta do presente estudo foi avaliar os efeitos da suplementação de leucina associada ao treinamento resistido (TR) de alta intensidade sobre a força muscular em sujeitos jovens não treinados. Para tanto, 24 indivíduos jovens não treinados, de ambos os sexos, foram divididos em dois grupos (N = 12/grupo): Leucina (4g de leucina + 8g dextrose) e Placebo (12g dextrose). Ambos os grupos foram submetidos a um programa de TR de alta intensidade (3 séries de 12 repetições máximas; 2x/semana) com duração de 6 semanas, e consumiram seus respectivos suplementos imediatamente após cada sessão de treino. As sessões de treino consistiram na realização dos exercícios de leg press e cadeira extensora, a fim de maximizar o recrutamento do músculo quadríceps. Ambos os grupos foram submetidos ao teste de uma repetição máxima (1RM) nos exercícios de leg press e cadeira extensora, nos momentos pré e pós-treinamento. Ao término do treinamento, houve um significante (P < 0,05) aumento do 1RM em ambos os exercícios, mas nenhuma diferença foi observada entre os grupos. Além disso, a progressão da carga de treino foi similar (P > 0,05) entre os grupos, após 4 e 6 semanas de treinamento. Estes resultados indicam que a suplementação de uma baixa dose semanal de leucina (4g/dia; 2x/semana) associada ao TR em curto prazo não promove efeitos adicionais sobre a força muscular em indivíduos jovens não treinados.Palavras-chave: Músculo Esquelético. Suplementação Alimentar. Leucina.AbstractThe purpose of the study herein was to examine the leucine supplementation effects associated with high-intensity resistance training (RT) on muscle strength in young untrained subjects. Twenty-four young untrained subjects fromboth sexes were divided into two groups (N = 12/ group): Leucine (4g leucine + 8g dextrose) and Placebo (12g dextrose). Both groups underwent a 6-wk high-intensity RT program (3 sets of 12 maximal repetitions; 2x/week), and consumed their respective supplements immediately after each training session. The training sessions consisted of performing leg press and knee extension exercises, in order to maximize the recruitment of the quadriceps muscle. Both groups performed the one-repetition maximum (1RM) test in the leg press and extensor chair exercises at pre- and post-training. After RT program, there was a significant (P < 0.05) increased 1RM in both exercises, but no difference was observed between the groups. In addition, the training load progression was similar (P > 0.05) between the groups after 4 and 6 weeks of training. These results indicate that low dose supplementation of leucine (4g/day; 2x/week) associated with a short-term RT program does not promote additional effects on muscle strength in untrained young subjects.Keywords: Skeletal Muscle. Supplementary Feeding. Leucine.