bluuebunny/crossref_metadata_2025 huggingface dataset:
Shared Decision Making with Acutely Hospitalized, Older Poly-Medicated Patients: A Mixed-Methods Study in an Emergency Department
Authors: Fabricius Pia Keinicke , Aharaz Anissa , Stefánsdóttir Nina Thórný , Houlind Morten Baltzer , Steffensen Karina Dahl , Andersen Ove , Kirk Jeanette Wassar
Published: May 2022

Shared decision making (SDM) about medicine with older poly-medicated patients is vital to improving adherence and preventing medication-related hospital admissions, but it is difficult to achieve in practice. This study’s primary aim was to provide insight into the extent of SDM in medication decisions in the Emergency Department (ED) and to compare how it aligns with older poly-medicated patients’ preferences and needs. We applied a mixed-methods design to investigate SDM in medication decisions from two perspectives: (1) observational measurements with the observing patient involvement (OPTION 5) instrument of healthcare professionals’ SDM behavior in medication decisions and (2) semi-structured interviews with older poly-medicated patients. A convergent parallel analysis was performed. Sixty-five observations and fourteen interviews revealed four overall themes: (1) a low degree of SDM about medication, (2) a variation in the pro-active and non-active patients approach to conversations about medicine, (3) no information on side effects, and (4) a preference for medication reduction. The lack of SDM with older patients in the ED may increase inequality in health. Patients with low health literacy are at risk of safety threats, nonadherence, and preventable re-admissions. Therefore, healthcare professionals should systematically investigate older poly-medicated patients’ preferences and discuss the side effects and the possibility of reducing harmful medicine.
Visualizing the Knowledge Domain in Health Education: A Scientometric Analysis Based on CiteSpace
Authors: Chen Boyuan , Shin Sohee , Wu Ming , Liu Zhihui
Published: May 2022

Objectives: This study aimed to visualize the evidence in the global research on health education to better improve the nation’s health literacy and to guide future research. Method: We searched the Web of Science (Core Collection) electronic databases. The search strategies: topic: (“Health Education” OR “Education, Health” OR “Community Health Education” OR “Education, Community Health” OR “Health Education, Community”) AND document: (Article) AND language:(English). Articles of evidence from January 2011 to December 2021 with those words in the title or abstract or keywords will be included in this review. We used the Citespace 5.6.R5 (64-bit) to investigate and determine the thematic patterns, and emerging trends of the knowledge domain, and presented a narrative account of the findings. Result: We analyzed 10,273 eligible articles. It showed that BMC Public Health displays the most prolific journals. Author MARCO PAHOR is highlighted in health education. The University of Sydney has published the most studies about health education. The USA plays an important role in these studies. Specifically, the visualization shows several hotspots: disease prevalence surveys and a specific population of knowledge, attitude and practice surveys, health intervention, chronic and non-communicable management, youth-health action, sexual and reproductive health, and physical activity promotion. Furthermore, document co-citation analysis indicated that there are 10 main clusters, which means the research front in health education. Meanwhile, by the citation detected, COVID-19, has achieved universal health coverage in related studies, however, public health education and the health workforce might be more popular in the coming years. Conclusion: Health education is an effective measure to shift the concept of public health and improve healthy living standards. The present study facilitates an extensive understanding of the basic knowledge and research frontiers that are pivotal for the developmental process of health education and allows scholars to visualize the identification modes and tendencies.
Tooth Loss Related with Prevalence of Metabolic Syndrome in a General Urban Japanese Population: The Suita Study
Authors: Ono Takahiro , Kato Satoshi , Kokubo Yoshihiro , Hasegawa Yoko , Kosaka Takayuki , Maeda Yoshinobu , Okamura Tomonori , Miyamoto Yoshihiro , Ikebe Kazunori
Published: May 2022

We examined whether the number of teeth could be a surrogate marker for metabolic syndrome (MetS) risk in cross-section. A total of 3771 individuals from the general urban Japanese population (1690 men, 2081 women; mean age 67.1 ± 11.0 years) participated in this study. Participants were diagnosed with MetS with three or more components hypertension, hyperglycemia, lipid metabolism abnormality, and abnormal abdominal girth. Questionnaires were administered to determine the number of teeth, smoking status, drinking status, and past illnesses. To clarify the relationships between the number of teeth and the presence of MetS components, we divided subjects into two groups: those with less than 20 residual teeth and those with 20 or more, then statistical analyses (Mantel-Haenszel tests and logistic regression analysis) were performed. MetS were higher for those with ≤19 teeth than those with ≥20 teeth when examining all participants and women-only groups. Hyperglycemia, low HDL cholesterol, high triglycerides, and diagnosis with MetS were all significantly higher in the ≤19 teeth group for both sexes combined and for women. These results suggest that less than 20 teeth may be a surrogate marker for MetS risk, but further studies on gender differences and pathological background are needed.
Field Evaluation of an Automated Pollen Sensor
Authors: Jiang Chenyang , Wang Wenhao , Du Linlin , Huang Guanyu , McConaghy Caitlin , Fineman Stanley , Liu Yang
Published: May 2022

Background: Seasonal pollen is a common cause of allergic respiratory disease. In the United States, pollen monitoring occurs via manual counting, a method which is both labor-intensive and has a considerable time delay. In this paper, we report the field-testing results of a new, automated, real-time pollen imaging sensor in Atlanta, GA. Methods: We first compared the pollen concentrations measured by an automated real-time pollen sensor (APS-300, Pollen Sense LLC) collocated with a Rotorod M40 sampler in 2020 at an allergy clinic in northwest Atlanta. An internal consistency assessment was then conducted with two collocated APS-300 sensors in downtown Atlanta during the 2021 pollen season. We also investigated the spatial heterogeneity of pollen concentrations using the APS-300 measurements. Results: Overall, the daily pollen concentrations reported by the APS-300 and the Rotorod M40 sampler with manual counting were strongly correlated (r = 0.85) during the peak pollen season. The APS-300 reported fewer tree pollen taxa, resulting in a slight underestimation of total pollen counts. Both the APS-300 and Rotorod M40 reported Quercus (Oak) and Pinus (Pine) as dominant pollen taxa during the peak tree pollen season. Pollen concentrations reported by APS-300 in the summer and fall were less accurate. The daily total and speciated pollen concentrations reported by two collocated APS-300 sensors were highly correlated (r = 0.93–0.99). Pollen concentrations showed substantial spatial and temporal heterogeneity in terms of peak levels at three locations in Atlanta. Conclusions: The APS-300 sensor was able to provide internally consistent, real-time pollen concentrations that are strongly correlated with the current gold-standard measurements during the peak pollen season. When compared with manual counting approaches, the fully automated sensor has the significant advantage of being mobile with the ability to provide real-time pollen data. However, the sensor’s weed and grass pollen identification algorithms require further improvement.
The Link between Subjective Religiosity, Social Support, and Mental Health among Young Students in Eastern Europe during the COVID-19 Pandemic: A Cross-Sectional Study of Poland and Ukraine
Authors: Długosz Piotr , Liszka Damian , Yuzva Luydmila
Published: May 2022

Religiousness has a positive effect on the mental health of an individual and social groups in many difficult situations. In the conducted research, we wanted to check, inter alia, whether religiosity and social support are positively related to the mental health of students during the COVID-19 pandemic in Poland and Ukraine. The research was conducted at a time (August 2021) when the very contagious Delta variant was spreading over Europe, and numerous pandemic-related personal restrictions and obligations (such as using facemasks in selected places, social distancing, and obligatory self-isolation of the ill or those who had contact with the pathogen) were in force in both countries. For this purpose, a representative survey was carried out using the CAPI technique on a sample of 1000 students in Poland (50% boys and 50% girls in the age range 10–19) and 1022 in Ukraine (51% boys and 49% girls in the age range 10–18). The results of the research shows that depression measured by the PHQ-9 scale was experienced by 20% of students in Poland, and 13% in Ukrainian. Anxiety, measured with the GAD-7 scale, was experienced by 9% of the Polish and 6% of the Ukrainian students. The performed regression analysis showed that religiosity had no effect on the mental health of students. The main risk factor for mental disorders was the lack of social support.
Effect of Rural Human Settlement Environment around Nature Reserves on Farmers’ Well-Being: A Field Survey Based on 1002 Farmer Households around Six Nature Reserves in China
Authors: Zhang Tingting , He Dan , Kuang Tian , Chen Ke
Published: May 2022

Numerous countries actively consider the human settlement environment and have implemented rural governance strategies to ameliorate the living conditions of rural dwellers. The construction of a rural human settlement environment is an important goal of China’s rural revitalization strategy and improving farmers’ well-being is a key element of China’s policies on agriculture, farmers, and villages. However, whether a rural human settlement environment enhances farmers’ well-being remains untested. By adopting the method of random stratified sampling, this study investigated 1002 farmers inside and outside six nature reserves in Liaoning, China. OLS and ordered probit regression models were used to assess the impact on the well-being and the satisfaction of farmers with their settlement environment around nature reserves from three aspects: the natural ecological environment, the hardware facility environment, and the daily governance environment. The results of this study proved that the construction of a human settlement environment can significantly boost the well-being of farmers. Moreover, the satisfaction towards the natural ecological environment, hardware facility environment, and daily governance environment exerts a substantial impact on the well-being at the significance level of 1%, with a positive sign, showing a stable enhancement role. Among them, the satisfaction with the hardware facility environment was the most essential for improving happiness, with a coefficient of 0.126. A heterogeneity analysis suggests that the positive effect of satisfaction with the human settlement environment on farmers’ well-being within nature reserves was more significant in the natural ecological environment, with a coefficient of 0.244; the hardware facility environment had the greatest positive effect on the well-being of farmers outside nature reserves, with a coefficient of 0.224; and the daily governance environment had a greater enhancing effect on the well-being of farmers both inside and outside nature reserves. Based on these results, it is recommended that governments encourage farmers around nature reserves to participate in wildlife accident insurance, strengthen ecological environmental protection, and enhance the hardware facility environment. Furthermore, local governments should disseminate knowledge of human settlement management to farmers and improve the efficiency of human settlement environment management at the grassroots level. Finally, governments should prioritize human settlement environment development and identify the farmers’ needs of human settlement environment to enhance their well-being.
Quality of Life of Gynaeoncology Patients and Family Caregivers
Authors: Hasan Raimi Zamriah , Ng Beng Kwang , Phon Su Ee , Abdul Karim Abdul Kadir , Lim Pei Shan , Nur Azurah Abdul Ghani
Published: May 2022

The quality of life of both gynaeoncology patients and their family caregivers is affected by disease. This was a cross-sectional study of gynaeoncology patients and their caregivers in a gynaeoncology clinic and ward in a tertiary centre from 1 November 2017 until 30 April 2018. EQ-5D-5L and SF-36 questionnaires were used for the assessment of quality of life. Sociodemographic characteristics and the quality of life of both patients and caregivers were studied. There were 176 patients approached and 7 patients declined to participate in the study, giving the response rate of 95.9%. A total of 169 patients were recruited and consented to this study. Whereas, for SF-36, five domains that were physical functioning, role limitation due to physical health, energy, pain, and general health were statistically significant between both groups (p < 0.05). Factors that favoured a high quality of life in patients were an early stage of cancer and the absence of comorbidities. While for caregivers, being single or educated was associated with a better quality of life. In our study, we found that the quality of life of gynaeoncology patients was lower than their caregivers based on EQ-5D-5L and SF-36 questionnaires.
Construction of Low-Carbon Ferry—A Case of Jingning, China
Authors: Yao Shiru , Cao Gengyong , Zhan Zi , Cao Qinqin , Fu Hailu , Dong Wenjie
Published: May 2022

As the Chinese government has pledged to reach its carbon peak by 2030 and carbon neutrality by 2060, it is necessary to investigate how regional sustainable development can be achieved. This paper used a ‘bottom-up’ model to calculate the ferry carbon emissions in Jingning, China, and proposed four measures to reduce carbon emissions, including renewing ferryboats, planting water-level-fluctuating zones, greening the ferries, and installing solar energy. Quantitative analyses were conducted to calculate the possible emissions reduction from 2021 to 2025, with the results indicating that the total emissions could be reduced by 392.67 t. Finally, a new low-carbon ferry concept is proposed, based on simultaneous carbon emission reduction and carbon sink enhancement. This study provided a theoretical and decision-making reference for the operation of green, beautiful, and low-carbon ferries.
Canada’s Colonial Genocide of Indigenous Peoples: A Review of the Psychosocial and Neurobiological Processes Linking Trauma and Intergenerational Outcomes
Authors: Matheson Kimberly , Seymour Ann , Landry Jyllenna , Ventura Katelyn , Arsenault Emily , Anisman Hymie
Published: May 2022

The policies and actions that were enacted to colonize Indigenous Peoples in Canada have been described as constituting cultural genocide. When one considers the long-term consequences from the perspective of the social and environmental determinants of health framework, the impacts of such policies on the physical and mental health of Indigenous Peoples go well beyond cultural loss. This paper addresses the impacts of key historical and current Canadian federal policies in relation to the health and well-being of Indigenous Peoples. Far from constituting a mere lesson in history, the connections between colonialist policies and actions on present-day outcomes are evaluated in terms of transgenerational and intergenerational transmission processes, including psychosocial, developmental, environmental, and neurobiological mechanisms and trauma responses. In addition, while colonialist policies have created adverse living conditions for Indigenous Peoples, resilience and the perseverance of many aspects of culture may be maintained through intergenerational processes.
Diagnostic Process in Rare Diseases: Determinants Associated with Diagnostic Delay
Authors: Benito-Lozano Juan , Arias-Merino Greta , Gómez-Martínez Mario , Ancochea-Díaz Alba , Aparicio-García Aitor , Posada de la Paz Manuel , Alonso-Ferreira Verónica
Published: May 2022

Many people living with rare disease (RD) report a difficult diagnostic process from the symptom onset until they obtain the definitive diagnosis. The aim of this study was thus to ascertain the diagnostic process in RDs, and explore the determinants related with having to wait for more than one year in this process (defined as “diagnostic delay”). We conducted a case–control study, using a purpose-designed form from the Spanish Rare Diseases Patient Registry for data-collection purposes. A descriptive analysis was performed and multivariate backward logistic regression models fitted. Based on data on 1216 patients living with RDs, we identified a series of determinants associated with experiencing diagnostic delay. These included: having to travel to see a specialist other than that usually consulted in the patient’s home province (OR 2.1; 95%CI 1.6–2.9); visiting more than 10 specialists (OR 2.6; 95%CI 1.7–4.0); being diagnosed in a region other than that of the patient’s residence at the date of symptom onset (OR 2.3; 95%CI 1.5–3.6); suffering from a RD of the nervous system (OR 1.4; 95%CI 1.0–1.8). In terms of time taken to see a specialist, waiting more than 6 months to be referred from the first medical visit was the period of time which most contributed to diagnostic delay (PAR 30.2%). In conclusion, this is the first paper to use a collaborative study based on a nationwide registry to address the diagnostic process of patients living with RDs. While the evidence shows that the diagnostic process experienced by these persons is complex, more studies are needed to determine the implications that this has for their lives and those of their families at a social, educational, occupational, psychological, and financial level.
Impact of Unsustainable Environmental Conditions Due to Vehicular Emissions on Associated Lifetime Cancer Risk in India: A Novel Approach
Authors: Thind Parteek Singh , Kumar Deepak , Singh Sandeep , Chohan Jasgurpreet Singh , Kumar Raman , Sharma Shubham , Li Changhe , Di Bona Gianpaolo , Forcina Antonio , Silvestri Luca
Published: May 2022

The Indian Western Himalayas (IWHs) are a world famous tourist spot, and every year millions of tourists visit this area in fossil fuel-driven vehicles. Emissions from these vehicles persistently deteriorate the pristine environment of the IWHs. Therefore, in the current study, efforts were made to assess the compromised environmental conditions of Manali, Himachal Pradesh, India that resulted from the inflow of tourists and the activities undertaken by them. This study revealed that Manali could sustainably accommodate only 0.305 M tourists/month, and this threshold was reported to be crossed in the months of April, May and June. Furthermore, to augment these findings, water and ambient air samples were collected and analyzed for the presence of elemental carbon (EC) from one of the medium tourism potential regions of Manali, i.e., the Hamta glacier. The tributary receiving water from the Hamta glacier and the ambient air of the area was observed to be contaminated with 42 ± 12 ppb and 880 ± 43 µg m−3 of EC, respectively. It was observed that the inhalation and ingestion of EC-contaminated air and water could jeopardize human health due to a high lifetime cancer risk. However, without the intervention of eco-tourism in the study area, higher environmental health effects were also speculated. The observations made in this study are expected to trigger the interests of the researchers, international scientific community and regional authorities working towards the unsustainable development of the IWHs and deteriorating environmental conditions.
The Influence of Faith and Religion on Family Interactions and Interest in Health Issues during the COVID-19 Pandemic—A Study among Polish Adolescents
Authors: Kasielska-Trojan Anna , Dzierżak Julian , Antoszewski Bogusław
Published: May 2022

Background: COVID-19 has dominated health, economic, and geopolitical issues for many months, but it also has great influence on individuals and families. The aim of this study was to verify whether the pandemic of COVID-19 changed religious practices and how religiosity moderated the influence of the pandemic on family interactions and attitudes towards health issues in adolescents. Methods: The study groups included 561 adolescent high school students (314 females and 247 males) from two kinds of high schools: public and Catholic. Results: Most Catholic school students have not changed their religious practices during the pandemic or just changed the form of attendance to TV or internet (59.7%). Moreover, 8.6% of them stopped the practices, in comparison with 12.9% of public school students, most of whom had not attended a mass before and during the pandemic. The results showed that in adolescents’ opinions the pandemic caused family relations to be stronger, however this effect was modified by religiosity. Conclusion: Attending Catholic school and being a practicing believer influenced some aspects of faith and family relations during the pandemic, but in most aspects, they did not influence attitudes toward health issues. The results of the study highlight the need to secure, especially for non-believing adolescents, family support during the pandemic, while in believers faith may provide such support.
Cultural Adaptation and Validity Testing of the Portuguese Version of the Health Literacy Questionnaire (HLQ)
Authors: Do Ó Dulce Nascimento , Goes Ana Rita , Elsworth Gerald , Raposo João F. , Loureiro Isabel , Osborne Richard H.
Published: May 2022

Background: Health literacy is considered a determinant of self-management behaviors and health outcomes among people with diabetes. The assessment of health literacy is central to understanding the health needs of a population. This study aimed to adapt the Health Literacy Questionnaire (HLQ) to the Portuguese context and to examine the psychometric properties of a population of people with diabetes. Methods: Data were collected using a self-administrated questionnaire from 453 people with diabetes in a specialized diabetes care unit. Analysis included item difficulty level, composite scale reliability, and confirmatory factor analysis (CFA). Results: The HLQ showed that the items were easily understood by participants. Composite reliability ranged from 0.74 to 0.83. A nine-factor CFA model was fitted to the 44 items. Given the very restricted model, the fit was quite satisfactory [χ2wlsmv = 2147.3 (df = 866), p = 0.001; CFI = 0.931, TLI = 0.925, RMSEA = 0.057 (90% C.I. 0.054–0.060), and WRMR = 1.528]. Conclusion: The Portuguese version of the HLQ has shown satisfactory psychometric properties across its nine separate scales in people with diabetes. Given the strong observed properties of the HLQ across cultures, languages, and diseases, the HLQ is likely to be a useful tool in a range of Portuguese settings.
Awe and Prosocial Behavior: The Mediating Role of Presence of Meaning in Life and the Moderating Role of Perceived Social Support
Authors: Fu Ya-Nan , Feng Ruodan , Liu Qun , He Yumei , Turel Ofir , Zhang Shuyue , He Qinghua
Published: May 2022

Although awe has been shown to increase prosocial behavior, there is limited knowledge about the mechanisms underlying this relationship, and about this relationship during unique periods. To bridge these gaps, this study examined the influence of awe on prosocial behaviors, the mediating role of the presence of meaning in life, and the moderating role of perceived social support. Based on longitudinal surveys from 676 Chinese college students we showed that: (1) awe was positively associated with prosocial behavior; (2) the presence of meaning in life mediated this association, and; (3) these associations were moderated by perceived social support. Specifically, the positive relationship between awe and the presence of meaning in life was only significant for college students with low perceived social support; and the positive relationship between the presence of meaning in life and prosocial behavior was stronger for college students with high perceived social support.
Developing Students’ Emotional Competencies in English Language Classes: Reciprocal Benefits and Practical Implications
Authors: Gay Philippe , Pogranova Slavka , Mauroux Laetitia , Trisconi Estelle , Rankin Emily , Shankland Rebecca
Published: May 2022

Learning a foreign language involves a wide range of cognitive, social and affective skills. The present article gives ideas to develop socio-emotional competencies in English courses: the capacity to identify the emotion, to understand the causes and consequences, to express their emotions and to do so in a socially acceptable manner, to manage stress and to use their emotions to increase the effectiveness of thinking, decision making and actions. Content and language integrated learning (CLIL) is a dual approach aiming to develop both language and academic subject knowledge. It may be gradually introduced, embedding it at three levels: into the classroom (routines, organization, pupils’ behavior), the school and the curriculum. Successful learning in CLIL remains based on (1) communication, (2) ways of engaging in the learning process and (3) the use of meaning-making strategies. We propose a pedagogical sequence (several courses) to learn a second language based on the social and emotional learning approach, and the English coursebook MORE! 7e for primary school pupils (aged 10–11). We combine the specific language learning of the unit—talking about ourselves, people and their feelings—with the development of pupils’ basic emotional competencies, and discuss advantages and disadvantages to consider in order to successfully implement such lessons.
Optimizing Strategies for Improving Mental Health in Victoria, Australia during the COVID-19 Era: A System Dynamics Modelling Study
Authors: Vacher Catherine , Ho Nicholas , Skinner Adam , Robinson Jo , Freebairn Louise , Lee Grace Yeeun , Iorfino Frank , Prodan Ante , Song Yun Ju C. , Occhipinti Jo-An , Hickie Ian B.
Published: May 2022

The ongoing COVID-19 pandemic has impacted the mental health of populations and highlighted the limitations of mental health care systems. As the trajectory of the pandemic and the economic recovery are still uncertain, decision tools are needed to help evaluate the best interventions to improve mental health outcomes. We developed a system dynamics model that captures causal relationships among population, demographics, post-secondary education, health services, COVID-19 impact, and mental health outcomes. The study was conducted in the Australian state of Victoria. The model was calibrated using historical data and was stratified by age group and by geographic remoteness. Findings demonstrate that the most effective intervention combination includes economic, social, and health sector initiatives. Assertive post-suicide attempt care is the most impactful health sector intervention, but delaying implementation reduces the potency of its impact. Some evidence-based interventions, such as population-wide community awareness campaigns, are projected to worsen mental health outcomes when implemented on their own. Systems modelling offers a powerful decision-support tool to test alternative strategies for improving mental health outcomes in the Victorian context.
A Public Health Perspective of Post-Traumatic Stress Disorder
Authors: Al Jowf Ghazi I. , Ahmed Ziyad T. , An Ning , Reijnders Rick A. , Ambrosino Elena , Rutten Bart P. F. , de Nijs Laurence , Eijssen Lars M. T.
Published: May 2022

Trauma exposure is one of the most important and prevalent risk factors for mental and physical ill-health. Prolonged or excessive stress exposure increases the risk of a wide variety of mental and physical symptoms, resulting in a condition known as post-traumatic stress disorder (PTSD). The diagnosis might be challenging due to the complex pathophysiology and co-existence with other mental disorders. The prime factor for PTSD development is exposure to a stressor, which variably, along with peritraumatic conditions, affects disease progression and severity. Additionally, many factors are thought to influence the response to the stressor, and hence reshape the natural history and course of the disease. With sufficient knowledge about the disease, preventive and intervenient methods can be implemented to improve the quality of life of the patients and to limit both the medical and economic burden of the disease. This literature review provides a highlight of up-to-date literature on traumatic stress, with a focus on causes or triggers of stress, factors that influence response to stress, disease burden, and the application of the social-ecological public health model of disease prevention. In addition, it addresses therapeutic aspects, ethnic differences in traumatic stress, and future perspectives, including potential biomarkers.
Spatial Disparity of Visitors Changes during Particulate Matter Warning Using Big Data Focused on Seoul, Korea
Authors: Lee Sang-Hyeok , Kang Jung Eun
Published: May 2022

This study examined the changes in the number of visitors to regions during periods of high particulate matter (PM) concentrations in Seoul and analyzed the regional differences of these changes. Further, it examined the spatial characteristics that affect these regional differences. This study mapped the regional differences by conducting a spatial cluster analysis using GIS and examined factors affecting the regional differences using logistic regression analysis. The visiting population data used in this study were obtained from the Big Data on the de facto population measured every hour at mobile base stations, and all analyses were conducted in terms of weekdays and weekends. The results indicated that the visiting population decreases significantly on weekdays when there are high PM concentrations; however, visits increase on weekends, even during periods of high PM concentrations. Moreover, there was a huge regional gap in visiting population changes. Regions with more commercial use, higher bus accessibility, and better pedestrian environment (pedestrian paths, Walk Score) were more likely to be hotspots, whereas regions with high residential and industrial use were more likely to be cold spots. These results can be used as the basic data for PM policies based on regional characteristics.
Empirical Research on Male Preference in China: A Result of Gender Imbalance in the Seventh Population Census
Authors: Zhang Yanzhe , Zou Bowen , Zhang Huai , Zhang Jian
Published: May 2022

The Seventh National Population Census, recently conducted in 2020, reported the most up-to-date information on the size, structure, and distribution of China’s population. The results showed that the gender imbalance in China is still severe compared with the international standard. With the aim of understanding what has contributed to China’s gender imbalance, this study examined a range of potential influencing factors and measured the extent to which they have affected China’s sex structure. We gathered data from 3100 citizens (100 surveys from each provincial-level administrative region in mainland China); the useful response rate was 87.5% (2713/3100). We relied on statistical analysis to investigate the phenomenon of male preference in China and used a logit regression to analyze the factors associated with this result. We inspected the factors associated with the perception according to gender, age, annual income, living location, educational level, nationality, family contribution, the ideology of being supported by sons, social status, ability to generate money, and carrying on the family name. The results showed that, among these factors, the relationship of family contribution, the ideology of being supported by sons, and carrying on the family name with male preference was significant. This study is among the first to explore the factors affecting male preference that could have resulted in China’s gender imbalance. The findings of this research are also important as references for the development of the population strategy and policy instruments used to manage the demographic problems in China.
Narrative-Based Environmental Education Improves Environmental Awareness and Environmental Attitudes in Children Aged 6–8
Authors: Yang Ben , Wu Ningning , Tong Zepeng , Sun Yan
Published: May 2022

Environmental education can effectively raise people’s awareness of environmental protection and encourage appropriate behaviors. This study explored the effect of narrative-based environmental education on children’s environmental awareness. To this end, we recruited first- and second-grade students from two elementary schools to participate in an experiment in which differences between the group receiving narrative-based environmental video education and the control group were compared. It was found that narrative-based environmental education can effectively promote children’s environmental awareness, which was mainly reflected in their environmental knowledge and environmental attitudes, however, not significant in their pro-environmental behavior intention. These findings support the implementation of environmental education for students in lower grades in the future.
Effects of Face Masks on Physiological Parameters and Voice Production during Cycling Activity
Authors: Astolfi Arianna , Puglisi Giuseppina Emma , Shtrepi Louena , Tronville Paolo , Marval Diaz Jesús Alejandro , Carullo Alessio , Vallan Alberto , Atzori Alessio , Ferri Ada , Dotti Francesca
Published: May 2022

This study investigates the effects of face masks on physiological and voice parameters, focusing on cyclists that perform incremental sports activity. Three healthy male subjects were monitored in a climatic chamber wearing three types of masks with different acoustic properties, breathing resistance, and air filtration performance. Masks A and B were surgical masks made of hydrophobic fabric and three layers of non-woven fabric of 100% polypropylene, respectively. Mask S was a multilayer cloth mask designed for sports activity. Mask B and Mask S behave similarly and show lower sound attenuation and sound transmission loss and lower breathing resistance than Mask A, although Mask A exhibits slightly higher filtration efficiency. Similar cheek temperatures were observed for Masks A and B, while a significantly higher temperature was measured with Mask S at incremental physical activity. No differences were found between the masks and the no-mask condition for voice monitoring. Overall, Mask B and Mask S are suitable for sports activities without adverse effects on voice production while ensuring good breathing resistance and filtration efficiency. These outcomes support choosing appropriate masks for sports activities, showing the best trade-off between breathing resistance and filtration efficiency, sound attenuation, and sound transmission loss.
The Effect of Built Environment on Physical Health and Mental Health of Adults: A Nationwide Cross-Sectional Study in China
Authors: Tang Jie , Chen Nanqian , Liang Hailun , Gao Xu
Published: May 2022

At present, there is a lack of research examining the relationships between the built environment and health status from a social epidemiological perspective. With this in mind, the present study aimed to explore the construct validity of housing/neighborhood conditions and evaluate the associations between the built environment and self-rated health among Chinese residents. To conduct the analysis, data from 4906 participants were derived from the 2016 China Labor-force Dynamics Survey (CLDS). Specifically, we used exploratory factor analysis to identify construct of housing/neighborhood factors and performed principal component regression (PCR) to assess the relationship between the built environment and both self-rated physical health and mental health. This process identified five common factors that corresponded to the built environment, including housing affordability, housing quality, neighborhood services, neighborhood physical environment, and perceived environment. The regression results suggested that housing affordability was negatively related to health status. Meanwhile, the services, physical environment, and perceived environment of neighborhoods were related to positive health outcomes. The influence of housing on health exhibits group heterogeneity: respondents in the 41 to 65 age group were most vulnerable to poor built environments. Whilst the results indicated that housing factors and neighborhood conditions were related to health outcomes, their influence varied across different age groups. Future interventions should be intentionally designed to target housing affordability and neighborhood factors, which may include the provision of housing assistance programs and planning layouts.
Effect of Separate and Combined Toxicity of Bisphenol A and Zinc on the Soil Microbiome
Authors: Zaborowska Magdalena , Wyszkowska Jadwiga , Borowik Agata , Kucharski Jan
Published: May 2022

The research objective was established by taking into account common sources of soil contamination with bisphenol A (B) and zinc (Zn2+), as well as the scarcity of data on the effect of metabolic pathways involved in the degradation of organic compounds on the complexation of zinc in soil. Therefore, the aim of this study was to determine the spectrum of soil homeostasis disorders arising under the pressure of both the separate and combined toxicity of bisphenol A and Zn2+. With a broad pool of indicators, such as indices of the effect of xenobiotics (IFX), humic acid (IFH), plants (IFP), colony development (CD), ecophysiological diversity (EP), the Shannon–Weaver and the Simpson indices, as well as the index of soil biological fertility (BA21), the extent of disturbances was verified on the basis of enzymatic activity, microbiological activity, and structural diversity of the soil microbiome. A holistic character of the study was achieved, having determined the indicators of tolerance (IT) of Sorghum Moench (S) and Panicum virgatum (P), the ratio of the mass of their aerial parts to roots (PR), and the SPAD leaf greenness index. Bisphenol A not only failed to perform a complexing role towards Zn2+, but in combination with this heavy metal, had a particularly negative effect on the soil microbiome and enzymatic activity. The NGS analysis distinguished certain unique genera of bacteria in all objects, representing the phyla Actinobacteriota and Proteobacteria, as well as fungi classified as members of the phyla Ascomycota and Basidiomycota. Sorghum Moench (S) proved to be more sensitive to the xenobiotics than Panicum virgatum (P).
An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases
Authors: Teleanu Daniel Mihai , Niculescu Adelina-Gabriela , Lungu Iulia Ioana , Radu Crina Ioana , Vladâcenco Oana , Roza Eugenia , Costăchescu Bogdan , Grumezescu Alexandru Mihai , Teleanu Raluca Ioana
Published: May 2022

Oxidative stress has been linked with a variety of diseases, being involved in the debut and/or progress of several neurodegenerative disorders. This review intends to summarize some of the findings that correlate the overproduction of reactive oxygen species with the pathophysiology of Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. Oxidative stress was also noted to modify the inflammatory response. Even though oxidative stress and neuroinflammation are two totally different pathological events, they are linked and affect one another. Nonetheless, there are still several mechanisms that need to be understood regarding the onset and the progress of neurodegenerative diseases in order to develop efficient therapies. As antioxidants are a means to alter oxidative stress and slow down the symptoms of these neurodegenerative diseases, the most common antioxidants, enzymatic as well as non-enzymatic, have been mentioned in this paper as therapeutic options for the discussed disorders.
Epoxyeicosatrienoic Acid and Prostanoid Crosstalk at the Receptor and Intracellular Signaling Levels to Maintain Vascular Tone
Authors: Malacarne Pedro Felipe , Bezzenberger Justus , Lopez Melina , Warwick Timothy , Müller Niklas , Brandes Ralf P. , Rezende Flávia
Published: May 2022

Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by the cytochrome P450-(CYP450)-mediated epoxygenation of arachidonic acid. EETs have numerous biological effects on the vascular system, but aspects including their species specificity make their effects on vascular tone controversial. CYP450 enzymes require the 450-reductase (POR) for their activity. We set out to determine the contribution of endothelial CYP450 to murine vascular function using isolated aortic ring preparations from tamoxifen-inducible endothelial cell-specific POR knockout mice (ecPOR−/−). Constrictor responses to phenylephrine were similar between control (CTR) and ecPOR−/− mice. Contrastingly, sensitivity to the thromboxane receptor agonist U46619 and prostaglandin E2 (PGE2) was increased following the deletion of POR. Ex vivo incubation with a non-hydrolyzable EET (14,15-EE-8(Z)-E, EEZE) reversed the increased sensitivity to U46619 to the levels of CTR. EETs had no effect on vascular tone in phenylephrine-preconstricted vessels, but dilated vessels contracted with U46619 or PGE2. As U46619 acts through RhoA-dependent kinase, this system was analyzed. The deletion of POR affected the expression of genes in this pathway and the inhibition of Rho-GTPase with SAR407899 decreased sensitivity to U46619. These data suggest that EET and prostanoid crosstalk at the receptor level and that lack of EET production sensitizes vessels to vasoconstriction via the induction of the Rho kinase system.
The Transcription Factor EB (TFEB) Sensitizes the Heart to Chronic Pressure Overload
Authors: Wundersitz Sebastian , Pablo Tortola Cristina , Schmidt Sibylle , Oliveira Vidal Ramon , Kny Melanie , Hahn Alexander , Zanders Lukas , Katus Hugo A. , Sauer Sascha , Butter Christian , Luft Friedrich C. , Müller Oliver J. , Fielitz Jens
Published: May 2022

The transcription factor EB (TFEB) promotes protein degradation by the autophagy and lysosomal pathway (ALP) and overexpression of TFEB was suggested for the treatment of ALP-related diseases that often affect the heart. However, TFEB-mediated ALP induction may perturb cardiac stress response. We used adeno-associated viral vectors type 9 (AAV9) to overexpress TFEB (AAV9-Tfeb) or Luciferase-control (AAV9-Luc) in cardiomyocytes of 12-week-old male mice. Mice were subjected to transverse aortic constriction (TAC, 27G; AAV9-Luc: n = 9; AAV9-Tfeb: n = 14) or sham (AAV9-Luc: n = 9; AAV9-Tfeb: n = 9) surgery for 28 days. Heart morphology, echocardiography, gene expression, and protein levels were monitored. AAV9-Tfeb had no effect on cardiac structure and function in sham animals. TAC resulted in compensated left ventricular hypertrophy in AAV9-Luc mice. AAV9-Tfeb TAC mice showed a reduced LV ejection fraction and increased left ventricular diameters. Morphological, histological, and real-time PCR analyses showed increased heart weights, exaggerated fibrosis, and higher expression of stress markers and remodeling genes in AAV9-Tfeb TAC compared to AAV9-Luc TAC. RNA-sequencing, real-time PCR and Western Blot revealed a stronger ALP activation in the hearts of AAV9-Tfeb TAC mice. Cardiomyocyte-specific TFEB-overexpression promoted ALP gene expression during TAC, which was associated with heart failure. Treatment of ALP-related diseases by overexpression of TFEB warrants careful consideration.
Cytokinin Confers Brown Planthopper Resistance by Elevating Jasmonic Acid Pathway in Rice
Authors: Zhang Xiao , Liu Daoming , Gao Dong , Zhao Weining , Du Huaying , Qiu Zeyu , Huang Jie , Wen Peizheng , Wang Yongsheng , Li Qi , Wang Wenhui , Xu Haosen , He Jun , Liu Yuqiang , Wan Jianmin
Published: May 2022

Plants have evolved a sophisticated defense system that employs various hormone pathways to defend against attacks by insect pests. Cytokinin (CK) plays an important role in plant growth and stress tolerance, but the role of CKs in plant–insect interaction remains largely unclear. Here, we report that CKs act as a positive regulator in rice resistance against brown planthopper (BPH), a devastating insect pest of rice. We found that BPH feeding promotes CK biosynthesis and signaling in rice. Exogenous application of CKs significantly increased the rice resistance to BPH. Increasing endogenous CKs by knocking out cytokinin oxidase/dehydrogenase (OsCKXs) led to enhanced resistance to BPH. Moreover, the levels of the plant hormone jasmonic acid (JA) and the expression of JA-responsive genes were elevated by CK treatment and in OsCKXs knockout plants. Furthermore, JA-deficient mutant og1 was more susceptible to BPH, and CK-induced BPH resistance was suppressed in og1. These results indicate that CK-mediated BPH resistance is JA-dependent. Our findings provide the direct evidence for the novel role of CK in promoting insect resistance, and demonstrate that CK-induced insect resistance is JA-dependent. These results provide important guidance for effective pest management strategies in the future.
Correction of Beta-Thalassemia IVS-II-654 Mutation in a Mouse Model Using Prime Editing
Authors: Zhang Haokun , Sun Ruilin , Fei Jian , Chen Hongyan , Lu Daru
Published: May 2022

Prime editing was used to insert and correct various pathogenic mutations except for beta-thalassemia variants, which disrupt functional beta-globin and prevent hemoglobin assembly in erythrocytes. This study investigated the effect of gene correction using prime editor version 3 (PE3) in a mouse model with the human beta-thalassemia IVS-II-654 mutation (C > T). The T conversion generates a 5′ donor site at intron 2 of the beta-globin gene resulting in aberrant splicing of pre-mRNA, which affects beta-globin expression. We microinjected PE3 components (pegRNA, nick sgRNA, and PE2 mRNA) into the zygotes from IVS-II-654 mice to generate mutation-edited mice. Genome sequencing of the IVS-II-654 site showed that PE3 installed the correction (T > C), with an editing efficiency of 14.29%. Reverse transcription-PCR analysis showed that the PE3-induced conversion restored normal splicing of beta-globin mRNA. Subsequent comprehensive phenotypic analysis of thalassemia symptoms, including anemic hematological parameters, anisocytosis, splenomegaly, cardiac hypertrophy, extramedullary hematopoiesis, and iron overload, showed that the corrected IVS-II-654 mice had a normal phenotype identical to the wild type mice. Off-target analysis of pegRNA and nick sgRNA additionally showed the genomic safety of PE3. These results suggest that correction of beta-thalassemia mutation by PE3 may be a straightforward therapeutic strategy for this disease.