bluuebunny/crossref_metadata_2025 huggingface dataset:
From Premalignant Biology to Precision Interception: Connecting the Dots with a Curated Collection of Invited Articles
Authors: Colbert Maresso Karen , Maitra Anirban , Hawk Ernest T. , Vilar Eduardo
Published: July 2023

Nearly all cancers have identifiable histologically defined precursors known as precancers. These precancers offer a window of opportunity to intercept the neoplastic process to prevent its development into invasive cancer. However, lack of knowledge regarding the evolution of precancers and the microenvironmental pressures shaping them precludes efforts to intercept them. Technological developments over the past decade have facilitated the study of precancers at a previously unattainable resolution. Calls for a national PreCancer Atlas effort incorporating these technologies were heeded in 2018, with the launch of the Human Tumor Atlas Network (HTAN) as part of the Beau Biden National Cancer Moonshot. Since then, five funded HTAN groups have focused their efforts on profiling precancers from breast, colon, skin, and lung. In this time, what progress has been made? What is next for HTAN and the field of premalignant biology? And are there lessons that individual investigators and the larger prevention field can learn from this initial effort to accelerate the development of novel early detection methods, risk prediction biomarkers, and interception agents? A special collection of invited reviews by experts in cancer evolution, systems biology, immunology, cancer genetics, preventive agent development, among other areas, attempts to answer these questions.
Supplemental Figure 8 from Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer
Authors: Tsimberidou Apostolia M. , Guenther Kerstin , Andersson Borje S. , Mendrzyk Regina , Alpert Amir , Wagner Claudia , Nowak Anna , Aslan Katrin , Satelli Arun , Richter Fabian , Kuttruff-Coqui Sabrina , Schoor Oliver , Fritsche Jens , Coughlin Zoe , Mohamed Ali S. , Sieger Kerry , Norris Becky , Ort Rita , Beck Jennifer , Vo Henry Hiep , Hoffgaard Franziska , Ruh Manuel , Backert Linus , Wistuba Ignacio I. , Fuhrmann David , Ibrahim Nuhad K. , Morris Van Karlyle , Kee Bryan K. , Halperin Daniel M. , Nogueras-Gonzalez Graciela M. , Kebriaei Partow , Shpall Elizabeth J. , Vining David , Hwu Patrick , Singh Harpreet , Reinhardt Carsten , Britten Cedrik M. , Hilf Norbert , Weinschenk Toni , Maurer Dominik , Walter Steffen
Published: July 2023

Supplemental Figure 8
Supplemental Figure 3 from Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer
Authors: Tsimberidou Apostolia M. , Guenther Kerstin , Andersson Borje S. , Mendrzyk Regina , Alpert Amir , Wagner Claudia , Nowak Anna , Aslan Katrin , Satelli Arun , Richter Fabian , Kuttruff-Coqui Sabrina , Schoor Oliver , Fritsche Jens , Coughlin Zoe , Mohamed Ali S. , Sieger Kerry , Norris Becky , Ort Rita , Beck Jennifer , Vo Henry Hiep , Hoffgaard Franziska , Ruh Manuel , Backert Linus , Wistuba Ignacio I. , Fuhrmann David , Ibrahim Nuhad K. , Morris Van Karlyle , Kee Bryan K. , Halperin Daniel M. , Nogueras-Gonzalez Graciela M. , Kebriaei Partow , Shpall Elizabeth J. , Vining David , Hwu Patrick , Singh Harpreet , Reinhardt Carsten , Britten Cedrik M. , Hilf Norbert , Weinschenk Toni , Maurer Dominik , Walter Steffen
Published: July 2023

Supplemental Figure 3
Supplemental Figure 2 from Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer
Authors: Tsimberidou Apostolia M. , Guenther Kerstin , Andersson Borje S. , Mendrzyk Regina , Alpert Amir , Wagner Claudia , Nowak Anna , Aslan Katrin , Satelli Arun , Richter Fabian , Kuttruff-Coqui Sabrina , Schoor Oliver , Fritsche Jens , Coughlin Zoe , Mohamed Ali S. , Sieger Kerry , Norris Becky , Ort Rita , Beck Jennifer , Vo Henry Hiep , Hoffgaard Franziska , Ruh Manuel , Backert Linus , Wistuba Ignacio I. , Fuhrmann David , Ibrahim Nuhad K. , Morris Van Karlyle , Kee Bryan K. , Halperin Daniel M. , Nogueras-Gonzalez Graciela M. , Kebriaei Partow , Shpall Elizabeth J. , Vining David , Hwu Patrick , Singh Harpreet , Reinhardt Carsten , Britten Cedrik M. , Hilf Norbert , Weinschenk Toni , Maurer Dominik , Walter Steffen
Published: July 2023

Supplemental Figure 2
Supplemental Figure 1 from Feasibility and Safety of Personalized, Multi-Target, Adoptive Cell Therapy (IMA101): First-in-Human Clinical Trial in Patients with Advanced Metastatic Cancer
Authors: Tsimberidou Apostolia M. , Guenther Kerstin , Andersson Borje S. , Mendrzyk Regina , Alpert Amir , Wagner Claudia , Nowak Anna , Aslan Katrin , Satelli Arun , Richter Fabian , Kuttruff-Coqui Sabrina , Schoor Oliver , Fritsche Jens , Coughlin Zoe , Mohamed Ali S. , Sieger Kerry , Norris Becky , Ort Rita , Beck Jennifer , Vo Henry Hiep , Hoffgaard Franziska , Ruh Manuel , Backert Linus , Wistuba Ignacio I. , Fuhrmann David , Ibrahim Nuhad K. , Morris Van Karlyle , Kee Bryan K. , Halperin Daniel M. , Nogueras-Gonzalez Graciela M. , Kebriaei Partow , Shpall Elizabeth J. , Vining David , Hwu Patrick , Singh Harpreet , Reinhardt Carsten , Britten Cedrik M. , Hilf Norbert , Weinschenk Toni , Maurer Dominik , Walter Steffen
Published: July 2023

Supplemental Figure 1
Supplementary Tables from High Expression of MHC Class I Overcomes Cancer Immunotherapy Resistance Due to IFNγ Signaling Pathway Defects
Authors: Kawase Katsushige , Kawashima Shusuke , Nagasaki Joji , Inozume Takashi , Tanji Etsuko , Kawazu Masahito , Hanazawa Toyoyuki , Togashi Yosuke
Published: July 2023

Supplementary Table S1-S9
Table S5 from MYC Induces Immunotherapy and IFNγ Resistance Through Downregulation of JAK2
Authors: Markovits Ettai , Harush Ortal , Baruch Erez N. , Shulman Eldad D. , Debby Assaf , Itzhaki Orit , Anafi Liat , Danilevsky Artem , Shomron Noam , Ben-Betzalel Guy , Asher Nethanel , Shapira-Frommer Ronnie , Schachter Jacob , Barshack Iris , Geiger Tamar , Elkon Ran , Besser Michal J. , Markel Gal
Published: July 2023

Differential gene expression analysis between responders and non-responders to immunotherapy. Related to Figure 1.
Table S4 from MYC Induces Immunotherapy and IFNγ Resistance Through Downregulation of JAK2
Authors: Markovits Ettai , Harush Ortal , Baruch Erez N. , Shulman Eldad D. , Debby Assaf , Itzhaki Orit , Anafi Liat , Danilevsky Artem , Shomron Noam , Ben-Betzalel Guy , Asher Nethanel , Shapira-Frommer Ronnie , Schachter Jacob , Barshack Iris , Geiger Tamar , Elkon Ran , Besser Michal J. , Markel Gal
Published: July 2023

Similarity between TIL ACT and PD-1 blockade response mechanism. Related to Figure S1.
Table S3 from MYC Induces Immunotherapy and IFNγ Resistance Through Downregulation of JAK2
Authors: Markovits Ettai , Harush Ortal , Baruch Erez N. , Shulman Eldad D. , Debby Assaf , Itzhaki Orit , Anafi Liat , Danilevsky Artem , Shomron Noam , Ben-Betzalel Guy , Asher Nethanel , Shapira-Frommer Ronnie , Schachter Jacob , Barshack Iris , Geiger Tamar , Elkon Ran , Besser Michal J. , Markel Gal
Published: July 2023

Comparison between proteome and transcriptome profiling. Related to Figure 1.
Table S2 from MYC Induces Immunotherapy and IFNγ Resistance Through Downregulation of JAK2
Authors: Markovits Ettai , Harush Ortal , Baruch Erez N. , Shulman Eldad D. , Debby Assaf , Itzhaki Orit , Anafi Liat , Danilevsky Artem , Shomron Noam , Ben-Betzalel Guy , Asher Nethanel , Shapira-Frommer Ronnie , Schachter Jacob , Barshack Iris , Geiger Tamar , Elkon Ran , Besser Michal J. , Markel Gal
Published: July 2023

Patients’ clinical data.
Supplementary Figure Legends from MYC Induces Immunotherapy and IFNγ Resistance Through Downregulation of JAK2
Authors: Markovits Ettai , Harush Ortal , Baruch Erez N. , Shulman Eldad D. , Debby Assaf , Itzhaki Orit , Anafi Liat , Danilevsky Artem , Shomron Noam , Ben-Betzalel Guy , Asher Nethanel , Shapira-Frommer Ronnie , Schachter Jacob , Barshack Iris , Geiger Tamar , Elkon Ran , Besser Michal J. , Markel Gal
Published: July 2023

Supplementary Figure Legends
Supplementary Figure 5 from MYC Induces Immunotherapy and IFNγ Resistance Through Downregulation of JAK2
Authors: Markovits Ettai , Harush Ortal , Baruch Erez N. , Shulman Eldad D. , Debby Assaf , Itzhaki Orit , Anafi Liat , Danilevsky Artem , Shomron Noam , Ben-Betzalel Guy , Asher Nethanel , Shapira-Frommer Ronnie , Schachter Jacob , Barshack Iris , Geiger Tamar , Elkon Ran , Besser Michal J. , Markel Gal
Published: July 2023

Supplementary Figure 5
Supplementary Figure 1 from MYC Induces Immunotherapy and IFNγ Resistance Through Downregulation of JAK2
Authors: Markovits Ettai , Harush Ortal , Baruch Erez N. , Shulman Eldad D. , Debby Assaf , Itzhaki Orit , Anafi Liat , Danilevsky Artem , Shomron Noam , Ben-Betzalel Guy , Asher Nethanel , Shapira-Frommer Ronnie , Schachter Jacob , Barshack Iris , Geiger Tamar , Elkon Ran , Besser Michal J. , Markel Gal
Published: July 2023

Supplementary Figure 1
Supplemental Table 2 from mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity
Authors: Nirschl Christopher J. , Brodkin Heather R. , Domonkos Celesztina , Dwyer Connor J. , Hicklin Daniel J. , Ismail Nesreen , Seidel-Dugan Cynthia , Steiner Philipp , Steuert Zoe , Sullivan Jenna M. , Winston William M. , Salmeron Andres
Published: July 2023

Differential Gene Expression Analysis of Bulk RNA from MC38 Tumors After mWTX-330 Treatment
Supplemental Table 1 from mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity
Authors: Nirschl Christopher J. , Brodkin Heather R. , Domonkos Celesztina , Dwyer Connor J. , Hicklin Daniel J. , Ismail Nesreen , Seidel-Dugan Cynthia , Steiner Philipp , Steuert Zoe , Sullivan Jenna M. , Winston William M. , Salmeron Andres
Published: July 2023

Gene Ontology Analysis of RNA from MC38 Tumors Following mWTX-330 Treatment
Supplementary Data from Preclinical Evidence of an Allogeneic Dual CD20xCD22 CAR to Target a Broad Spectrum of Patients with B-cell Malignancies
Authors: Aranda-Orgilles Beatriz , Chion-Sotinel Isabelle , Skinner Jordan , Grudman Steven , Mumford Ben , Dixon Chantel , Postigo Fernandez Jorge , Erler Piril , Duchateau Phillipe , Gouble Agnes , Galetto Roman , Poirot Laurent
Published: July 2023

Supplementary Tables 1-4, supplementary Figures 1-10 and legends
Supplementary Fig. 9 from KRT17 Promotes T-lymphocyte Infiltration Through the YTHDF2–CXCL10 Axis in Colorectal Cancer
Authors: Liang Wenfeng , Liu Huashan , Zeng Ziwei , Liang Zhenxing , Xie Hao , Li Wenxin , Xiong Li , Liu Zhihang , Chen Mian , Jie Haiqing , Zheng Xiaobin , Huang Liang , Kang Liang
Published: July 2023

CXCL10 is indispensable for KRT7-mediated improved responsiveness to ICIs.
Supplementary Fig. 8 from KRT17 Promotes T-lymphocyte Infiltration Through the YTHDF2–CXCL10 Axis in Colorectal Cancer
Authors: Liang Wenfeng , Liu Huashan , Zeng Ziwei , Liang Zhenxing , Xie Hao , Li Wenxin , Xiong Li , Liu Zhihang , Chen Mian , Jie Haiqing , Zheng Xiaobin , Huang Liang , Kang Liang
Published: July 2023

KRT17 exerts an immunomodulatory effect through YTHDF2-CXCL10 axis.
Supplementary Fig. 3-4 from KRT17 Promotes T-lymphocyte Infiltration Through the YTHDF2–CXCL10 Axis in Colorectal Cancer
Authors: Liang Wenfeng , Liu Huashan , Zeng Ziwei , Liang Zhenxing , Xie Hao , Li Wenxin , Xiong Li , Liu Zhihang , Chen Mian , Jie Haiqing , Zheng Xiaobin , Huang Liang , Kang Liang
Published: July 2023

KRT17 expression is positively correlated with CD3+ and CD8+ densities in tumor parenchyma and invasive margin in CRC.
Data from Preclinical Evidence of an Allogeneic Dual CD20xCD22 CAR to Target a Broad Spectrum of Patients with B-cell Malignancies
Authors: Aranda-Orgilles Beatriz , Chion-Sotinel Isabelle , Skinner Jordan , Grudman Steven , Mumford Ben , Dixon Chantel , Postigo Fernandez Jorge , Erler Piril , Duchateau Phillipe , Gouble Agnes , Galetto Roman , Poirot Laurent
Published: July 2023

Abstract
Despite the remarkable success of autologous chimeric antigen receptor (CAR) T cells, some patients relapse due to tumor antigen escape and low or uneven antigen expression, among other mechanisms. Therapeutic options after relapse are limited, emphasizing the need to optimize current approaches. In addition, there is a need to develop allogeneic “off-the-shelf” therapies from healthy donors that are readily available at the time of treatment decision and can overcome limitations of current autologous approaches. To address both challenges simultaneously, we generated a CD20xCD22 dual allogeneic CAR T cell. Herein, we demonstrate that allogeneic CD20x22 CAR T cells display robust, sustained and dose-dependent activity in vitro and in vivo, while efficiently targeting primary B-cell non–Hodgkin lymphoma (B-NHL) samples with heterogeneous levels of CD22 and CD20. Altogether, we provide preclinical proof-of-concept data for an allogeneic dual CAR T cell to overcome current mechanisms of resistance to CAR T-cell therapies in B-NHL, while providing a potential alternative to CD19 targeting.
Supplementary Tables S1, S2, S5-S13 from The Polyamine–Hypusine Circuit Controls an Oncogenic Translational Program Essential for Malignant Conversion in MYC-Driven Lymphoma
Authors: Nakanishi Shima , Li Jiannong , Berglund Anders E. , Kim Youngchul , Zhang Yonghong , Zhang Ling , Yang Chunying , Song Jinming , Mirmira Raghavendra G. , Cleveland John L.
Published: July 2023

Supplementary Tables S1, S2, S5-S13 includes Supplementary Tables S1, S2, S5-S13.
Supplementary Table S1 provides a summary of BL and DHL patient demographics for the immunohistochemistry study presented in Fig. 1, E and F.
Supplementary Table S2 lists the MYC-dysregulated genes whose expression is significantly altered following depletion of eIF5A or DHPS, related to Fig. 4F.
Supplementary Table S5 shows DHPS GISTIC count and survival of select TCGA PanCancer datasets, related to Fig. 7J.
Supplementary Table S6 shows the genetic mouse models used in this study, related to Methods.
Supplementary Table S7 shows the mouse and human cell lines used in this study, related to Methods.
Supplementary Table S8 lists the antibodies used in this study, related to Methods.
Supplementary Table S9 lists reagents used in this study, related to Methods.
Supplementary Table S10 summarizes the plasmids used in this study, related to Methods.
Supplementary Table S11 lists the sequences of the oligonucleotides used in this study, related to Methods.
Supplementary Table S12 lists accession numbers and publicly deposited data from this study, related to Methods.
Supplementary Table S13 lists software and algorithms used in this study, related to Methods.
Comparison of Efficacy of Baricitinib and Dupilumab in the Treatment of Chinese Moderate-To-Severe Atopic Dermatitis: A Retrospective Study
Authors: Liu Bo , Song Xiaoting , Liao Shuanglu , Luan Tingting , Zhao Zuotao
Published: July 2023

Introduction: The treatment of atopic dermatitis (AD) patients with insufficient response or intolerance to topical medication remains clinical challenges, and there is a paucity of head-to-head trials comparing the efficacy of novel biological agents such as JAK inhibitor and antibody. Methods: To compare the efficacy of selective JAK1/JAK2 inhibitor baricitinib and interleukin-4 monoclonal antibody dupilumab in the treatment of patients with moderate-to-severe AD, a retrospective cohort study method was adopted. Clinical data from June 2020 to April 2022 were systematically reviewed. Eligible patients who received baricitinib or dupilumab were screened according to the following inclusion criteria: (1) age ≥ 18 years; (2) moderate-to-severe AD: baseline investigator global assessment (IGA) score ≥ 3, baseline eczema area and severity index (EASI) score ≥ 16; (3) poor response or intolerance to at least one topical drug in the past 6 months; (4) no topical glucocorticoids were used in the past 2 weeks and no systematic treatment was given in the past 4 weeks. Patients of the baricitinib group were treated with oral baricitinib in doses of 2 mg per day for 16 weeks, and patients of the dupilumab group were treated with standardized use of dupilumab for 16 weeks, with the initial 600 mg subcutaneous injection and the following 300 mg subcutaneous injection every 2 weeks. The clinical efficacy score indexes including the IGA score, EASI score, and Itch Numeric Rating Scale (NRS) score. These scores at 0, 2, 4, 8, 12, and 16 weeks after the start of treatment were collected. Results: A total of 54/45 patients treated with baricitinib/dupilumab were included. There was no significant difference in the decrease of all scores between the two groups at the 4th week (p > 0.05). There was no difference in the EASI score and Itch NRS score (p > 0.05), but the IGA score of the baricitinib group was lower at the 16th week (Z = 4.284, p < 0.001). Within the first 4 weeks, the Itch NRS score of the baricitinib group decreased rapidly, but with the prolongation of treatment time, there was no significant difference between the two groups at the 16th week (Z = 1.721, p = 0.085). Conclusions: The efficacy of baricitinib at a dose of 2 mg daily was similar to dupilumab, and the improvement in pruritus was significantly faster in the early stage of treatment (the first 4 weeks) than that of dupilumab.
Cognition and Financial Decision-Making in Older Adult Spouses
Authors: Coundouris Sarah P. , Hohn Sylvain , Basu Anup , Dulleck Uwe , Henry Julie D. , Cherbuin Nicolas
Published: July 2023

Introduction: Age-related decline in executive functioning has been found to negatively impact one’s capacity to make prudent financial decisions. The broader literature also speaks to the importance of considering interrelatedness in older spouses’ functioning, as these individuals typically represent one’s longest and closest relationship that involves an extended history of shared experiences. Accordingly, the aim of the present study was to provide the first examination of whether older adults’ financial decision-making capacity is impacted not only by their own but also by their partner’s, level of cognitive functioning. Method: Sixty-three heterosexual spousal dyads comprising older adults aged 60–88 participated. The contribution of executive functioning and perceptions of partner’s cognitive decline on financial decision-making behavior and financial competency was assessed through two actor-partner interdependence models. Results: As predicted, for both genders, one’s own executive functioning was predictive of one’s own financial decision-making capacity. However, of particular interest was the finding that for females (but not males) perceiving greater cognitive decline in their spouse predicted their own (greater) financial competency. Conclusion: Examining whether partner interdependence extends to the realm of financial decision-making is not only a theoretically but also practically important question. These data provide initial insights that such a relationship does exist and highlight further important avenues for future research.
An Analysis of the Growth and Photosynthetic Responses of Potted Veronica pusanensis Y.N.Lee according to the Shading Levels
Authors: Park Se Hoon , Lee Jae Hwan , Nam Sang Yong
Published: July 2023

Background and objective: Veronica pusanensis, an endemic species of South Korea belonging to the Plantaginaceae family, is found in Busan, South Korea. Due to its high ornamental value, it is expected to be utilized as a flower crop. However, currently it is an endangered species with its habitats being destroyed and reduced.Methods: Therefore, in this study, we analyzed the growth and photosynthetic responses of potted plants of V. pusanensis under different shading levels to enable mass production. Polyethylene (PE) shading films were selected as the shading material, and shading levels were designed at 0, 35, 45, 60, 75, and 99%, respectively.Results: Results showed that shoot height, shoot width, ground cover, leaf length, leaf width, shoot fresh and dry weight, chlorophyll content (SPAD units), and chlorophyll fluorescence parameters Fv/Fm and PIABS were highest under the 35% shading level. This indicates that it is relatively more desirable to grow V. pusanensis in shade culture compared to under direct sunlight. Meanwhile, root fresh weight and dry weight were highest under the 0% shading level.Conclusion: Therefore, it is recommended to grow V. pusanensis under direct sunlight to significantly increase root biomass when the purpose is to facilitate rootage when transplanting plants for habitat restoration. On the other hand, for the cultivation of V. pusanensis as an ornamental flower crop, it is recommended to grow the plants under the 35% shading level to significantly increase plant sizes and maintain ensure the proper functioning of photosynthetic responses in photosystem II (PSII).
Phylogenetic relationships of the West African mud turtle (Pelusios castaneus) on the islands of São Tomé and Príncipe, West Central Africa
Authors: Guedes Patrícia , dos Santos Yodiney , Matilde Estrela , Alves João , Rato Catarina , Rocha Ricardo
Published: July 2023

On the island nation of São Tomé and Príncipe, West Africa, only one species of terrapin has been recorded: the West African mud turtle, Pelusios castaneus. Here, we use a mtDNA phylogenetic approach to shed light on the geographical origin of Pelusios castaneus on both islands. Our results indicate several independent colonisations from different African mainland regions (Nigeria, Ivory Coast, Sierra Leone and Congo). However, it is still unclear if the species arrived on the islands by natural dispersal (e.g., through vegetation rafts) or by human agency (e.g., as a food source). Our work provides important insights into the origins of P. castaneus in São Tomé and Príncipe, but a more in-depth study is needed to fully understand the origins and evolutionary histories of these populations.
Local German Salafists and Saudi Arabia
Authors: Jaraba Mahmoud
Published: July 2023

Salafism in Germany is often viewed as a product of Saudi Arabia’s efforts to spread its conservative brand of Islam around the world. In recent years, the Kingdom has attempted to change its image both domestically and internationally by distinguishing itself from Salafism. The goal of this article is to look at how local Salafists, who have been supported by Saudi Arabia and religiously and ideologically shaped by Saudi Salafi scholars, are attempting to construct a localised and radicalised version of Salafism that is grounded in the German context, while also being critical of Saudi Arabia’s social liberalisation.
Checklist of the shallow-water marine Brachyura (Crustacea: Decapoda) of Barbados, West Indies
Authors: PARASRAM NADESHINIE , SANTANA WILLIAM , VALLÈS HENRI
Published: July 2023

Here we provide an illustrated and annotated checklist of brachyuran crabs associated with shallow water marine habitats (nearshore rubble and subtidal) in Barbados, West Indies (13.1939°N, 59.5432°W). Twenty-one (21) survey sites in nearshore rubble and shallow subtidal habitats were surveyed between October 2018 to September 2021. Nearshore rubble habitats were surveyed at low tide during the day and night periods. Shallow nearshore subtidal habitats were surveyed every 9–12 days from February to October 2019 using crab traps placed ~ 4 m deep on sandy and rocky bottoms. A total of 1,640 specimens were recorded, belonging to nine (9) superfamilies, 14 families, 34 genera, and 44 species. The genera Charybdis De Haan, 1833, Pitho Bell, 1835, Thoe Bell, 1835, and Uhlias Stimpson, 1871 are here reported for the first time for Barbados. Thirteen (13) species are first records for Barbados, thus extending their geographic range. The most abundant and widespread species collected was Mithraculus coryphe Herbst, 1801, which accounted for 35% (N = 570) of the specimens, occurring in both nearshore rubble and subtidal habitats.
On Certain Classes of Rectangular Designs
Authors: Singh Mithilesh Kumar , Saurabh Shyam
Published: July 2023

Rectangular designs are classified as regular, Latin regular, semi-regular, Latin semi-regular and singular designs. Some series of self-dual as well as α–resolvable designs which belong to the above classes are obtained. The building blocks of the designs are square (0, 1)-matrices. It is more general to view a class of designs based on an array than to view them based on disjoint groups of treatments of equal size. This generality enabled us to identify three subclasses of rectangular designs: Latin regular RDs, Latin semi-regular RDs and semi-regular L2-type designs which deserve further study. In every construction we obtain a matrix N with square (0, 1)-submatrices such that N becomes the incidence matrix of a rectangular design. The method is the reverse of the well-known tactical decomposition of the incidence matrix of a known design. The authors have already obtained some series of Group Divisible and L2-type designs using this method. Tactical decomposable designs are of great interest because of their connections with automorphisms of designs, see Bekar et al.[ 1 ] The rectangular designs constructed here are of statistical as well as combinatorial interest.

AMS Subject Classification: 62K10, 05B05
Predictors of long-stay in a tertiary care psychiatry hospital in India
Authors: Vranda Mysore Narasimha , Ranjith Prabhu James , Aadi Shivaleela , Gunasekaran Durai Murukan , Thirthalli Jagadisha , Naveen Kumar Channaveerachari , Thirumoorthy Ammapattian , Vasanthra Cicil Radhakrishnan , Amaresha Anekal Chandrareddy
Published: July 2023

Background:

Many psychiatric patients continue to stay for longer duration in psychiatric institutions. Community reintegration and rehabilitation of such patients needs to be explored to ensure appropriate bed occupancy rates and access to in-patient care for newer patients in need of the same.

Objectives:

The aim is to identify the risk and protective factors leading to long-term admission of mentally ill patients in tertiary care hospital.

Methodology:

A cross-sectional study was conducted with all patients in the long-stay ward between May 2018 and February 2023. A retrospective chart review followed by cross sectional assessment of risks and disability was carried out with all the patients living in a long-stay psychiatric ward ( N = 101) at a tertiary hospital in Bangalore, India, between May 2018 and February 2023.

Results:

The hospital’s average length of stay (LOS) was 5.70 ± 8.30 years. The risk and protective factors for LOS in psychiatric hospitals were analyzed using the Poisson Regression model. The results revealed that the male gender, diagnosis of schizophrenia or psychosis, clinicians’ knowledge of family information, good clinical improvement, and higher participation in ward activities are the protective factors for a shorter hospital stay. While higher age, family history of mental illness, being married and employed, absence of children, and/or having family members rarely visiting the patient at the hospital were some factors that increased the risk of LOS.

Conclusion:

This study highlighted the importance of possible LOS predictors in the tertiary care psychiatric hospital. The multi-disciplinary team may utilize risk and protective factors for delayed LOS to introduce comprehensive psychosocial interventions and policies that reduce the risk of delays or length of stay in mental health hospitals.
The Syntactic Pasts of Nouns Shape Their Prosodic Future: Lexico-Syntactic Effects on Position and Duration
Authors: Lester Nicholas A. , Katsika Argyro
Published: July 2023

Phrasal prosody is often viewed as a level of linguistic representation at which the phonetic profile of an utterance varies independently of the lexical items it contains. For example, the same word, when produced at the edges of prosodic phrases, will take longer to produce than when it is produced within the edges of a phrase. Lengthening effects have also been found for words when placed in different syntactic or lexical contexts. Recent evidence suggests that lexico-syntactic information—for example, the global syntactic distributions of words—affects phonetic duration in production, irrespective of other factors. The present study asks whether these lexico-syntactic effects on duration interact with prosodic position within the phrase. Specifically, we ask whether (a) the lexico-syntactic information of a word determines its prosodic position, and (b) whether, beyond any categorical effects on positioning, lexico-syntactic factors affect duration within prosodic positions. We address these questions using the Santa Barbara Corpus of Spoken American English. We operationalize syntactic information as the diversity and the typicality of the syntactic distributions of nouns based on a dependency parse of the British National Corpus. We find that earlier positions in the prosodic phrase generally prefer words with higher syntactic diversity. In addition, diversity and typicality modulate duration more reliably in nonfinal positions. Together, our results point to an early influence of lexico-syntactic considerations on prosodic planning.
The effect of nutrition on sleeve gastrectomy patients’ weight loss, biochemical measurements, and comorbids: A clinical study
Authors: Dallı Şen Seher , Erdem Nihal Zekiye
Published: July 2023

Background

This study investigates the effect of a nutrition program applied to patients as per bariatric surgery protocol at the sixth month postoperative. The study also compares and contrasts the postoperative findings with preoperative data.

Methods

Twenty severely obese sleeve gastrectomy patients between the ages of 18–65 participated in the study. Energy requirements were calculated as 22 kcal/ideal body weight (kg/day) and protein requirements as 1.5 g/ideal body weight (kg/day). The study evaluates patients’ anthropometric and biochemical measurements, body mass index, waist circumference, fat mass (%), weight loss (%), excess weight loss (%), comorbids, and dietary habits at the third and sixth months preoperative and postoperative. Patients’ daily macro-micronutrient intake was also calculated. The Friedman Test and Cochran's Q test were performed to determine statistically significant data ( p < 0.05).

Results

During the first 6 months postoperative, patients lost 34 kg of weight and 16.7% of fat mass, and their percent excess weight loss was measured at 60.2% (<0.0001). Biochemical measurements of the patients revealed that fasting blood glucose, low-density lipoprotein cholesterol, total cholesterol, triglyceride, and calcium levels, which were above the reference range in the preoperative period, were within this range in the postoperative period (<0.0001). Thirteen out of 21 comorbidities, including type 2 diabetes, hypertension, hyperlipidemia, pulmonary problems, and sleep apnea, improved at different rates in the sixth month postoperative.

Conclusions

Thanks to the nutrition program applied as per bariatric surgery protocol, patients lost weight, and their biochemical measurements and comorbids have improved following sleeve gastrectomy.
When couples fight about money, what do they fight about?
Authors: Peetz Johanna , Meloff Zoe , Royle Courtney
Published: July 2023

Conflicts about money and finances can be destructive for both the quality and longevity of relationships. This paper reports on a descriptive analysis of the contents of financial conflicts in two samples. Study 1 examined severe financial conflicts in social media posts ( N = 1014) from reddit ( r/relationships). Eight themes were identified via thematic analysis: “unfair relative contributions” “who pays for joint expenses”, “job and income”, “exceptional expenses”, “terms of financial arrangements”, “discrepant financial values”, “one-sided financial decisions”, and “perceived irresponsibility”. Study 2 examined reports of more mundane financial disagreements recalled by married individuals ( N = 481). Seven themes were identified via thematic analysis: “relative contributions”, “job and income”, “different values”, “exceptional expenses”, “mundane expenses”, “money management”, and “perceived irresponsibility”. In both samples, themes could be ordered along the dimensions of “concerns about fairness” and “concerns about responsibility”. The association of relationship outcomes (perceived partner responsiveness, couple satisfaction) with each theme and demographic predictors (income, relationship length, shared finances) were explored. Independent t-tests suggested that participants who recalled disagreements fitting the themes at the extreme ends of the two dimensions (“unfair relative contributions” and “perceived irresponsibility”) reported worse relationship outcomes. In contrast, participants recalling disagreements fitting the theme of “mundane expenses” reported better relationship outcomes.
Un-Disciplining the International
Authors: Bleiker Roland
Published: July 2023

Writing in the context of the call for greater diversity, this short commentary makes a dual argument about the need to ‘un-discipline’ the discipline of International Relations. First: I return to an argument I made many years ago: the need to ‘Forget IR Theory’ and to explore the key issues in global politics without being constraint by the boundaries of existing debates. Key political problems, from climate change and pandemics, are far too complex to be understood as uniquely international phenomena and through the lenses of disciplinary debates. Second: to un-discipline is not to abandon the study of international relations. Quite the contrary, forgetting the constraining boundaries of academic disciplines can involve engaging back with the discipline of International Relations but, crucially, not on its own terms and not through the debates that have pre-set the boundaries of what is and is not thinkable. Un-disciplining is a process that entails convincing disciplinary scholars of the need to see key dilemmas in global politics in new and creative ways.
Developing a Data-Driven Network Screening Procedure for Systemic Safety Approach
Authors: Shaon Mohammad Razaur Rahman , Zhao Shanshan , Wang Kai , Jackson Eric
Published: July 2023

Systemic analysis is considered an important safety analysis approach that is complementary to the Highway Safety Manual hotspot analysis. The network screening step in systemic analysis is to identify sites with characteristics that are associated with specific types of severe crashes. Traditionally, determining the risk scores involves subjective criteria. This research aims to develop a data-driven approach to replace the subjective methods used in the past. To achieve the research objective, this study collected roadway and crash data from the Connecticut Department of Transportation. A data-driven crash risk factor categorization methodology is proposed to estimate accurately the performance measures indicating crash risks. Moreover, this study proposes and compares four different risk scoring matrices to identify an optimal risk scoring method that is attuned with the principles of the systemic approach to safety as well as providing additional insights on justifying the systemic safety analysis results. The proposed methodology is implemented to conduct network screening for severe roadway departure crashes and later validated using severe aggressive-driving related crashes. Risk-based network screening results indicate that risk scores derived from normalized crash over-representation provide additional emphasis on sites with low traffic volume that are associated with high severe crash counts. The highest modified crash rate was obtained using normalized crash over-representation based risk scores indicating that the proposed network screening methodology can not only identify roadway attributes that are correlated with severe crashes but also account for low-volume roadway sites with severe crashes. The validation analysis indicated proposed method is transferrable to different emphasis area related crashes.
Impact of Size and Ownership on the Financial Performance of European Commercial Airports
Authors: Giovanelli Lucia , Rotondo Federico , Raghavan Sunder
Published: July 2023

Little research has been conducted on the financial performance of airports, especially in Europe. This paper employs benchmarking analysis to examine and compare the impact of different airport sizes and ownership structures on the financial performance of European airport companies. The sample consists of 188 European airport companies managing a total of 393 commercial airports. Financial performance is measured from four different perspectives: liquidity, activity, leverage and profitability, using 11 well-established financial metrics during the period 2007–2019. The findings confirm that size and ownership matter for airport financial performance. However, although an initial inspection reveals that medium-sized airports and private airport companies have the best overall performance, there are major differences in relation to different performance areas. For instance, small airport companies show higher liquidity performance and lower profitability, while large airport companies are the most indebted. Furthermore, public airport companies show superior liquidity performance and lower levels of indebtedness and profitability. This analysis provides policy guidance as to which airport companies are better equipped to manage unexpected challenges, such as that posed by the recent COVID-19 crisis, as well as future challenges such as sustainability issues, quality improvements, capacity constraints and attracting private investments.
Challenging Organizational Factors Associated With Admission Delay to Intensive Care Unit—A Novel Quality Indicator
Authors: Jakobson Daniel J. , Bashkin Osnat , Kalatskaya Viktoria , Veinberg Halel , Chernoguz Evgeny , Nesi Vicky , Levy Chezy , Sherer Yaniv
Published: July 2023

Background

Delays in admitting patients to the intensive care unit (ICU) can defer the timely initiation of life-sustaining therapies and invasive monitoring, jeopardizing the success of the treatment. Nevertheless, the availability of research on interventions that reduce or minimize admission delays is limited.

Objectives

The current study aimed to assess the factors related to delays in admission times of critically ill patients transferred to the ICU.

Methods

A software was designed to follow-up, compare and measure the defined intervals of the time to admission, implemented at the ICU for 6 months. Measurements included 5 time intervals, referral department, and work shift at admission. Data from 1004 patients admitted to the ICU between July 2017 and January 2020 were analyzed in a retrospective observational study.

Results

Precisely, 53.9% of total patients were referred from the hospital emergency department, and 44% were admitted during the evening shift. Significant differences were found in time intervals between shifts, showing the morning round had the longer total admission time (median: 67.8 min). Analysis showed that admission time was longer at times of full capacity compared to times of available bed (mean: 56.4 and 40.2 min, respectively; U = 68,722, p < .05). Findings demonstrated a significant shortening of time to admission after implementing a new time monitoring software by the Institutional Quality Control Commission ( U  =  5072, p < .001).

Conclusions

Our study opens doors for potential studies on applying effective initiatives in critical care settings to improve patient care and outcomes. Additionally, it generates new insights regarding how clinicians and nursing teams can jointly develop and promote multidisciplinary interventions in intensive care work environments.
Towards AI-driven transformation and smart data management: Emerging technological change in the public sector value chain
Authors: Valle-Cruz David , García-Contreras Rigoberto
Published: July 2023

Governments worldwide are beginning to implement AI-based services to exploit data and seek solutions that provide value to citizens and assist in decision-making. AI-driven transformation and smart data management can replace the workforce or enhance it. This paper focuses on exploring AI-driven transformation and smart data management in the public sector value chain. Guided by two research questions, a systematic literature review was conducted using the PRISMA approach, complemented with empirical evidence on the emerging technological change applied to management levels and decision-makers in the public sector. The needs related to AI-driven transformation and smart data management for the public sector are characterized by an operational transformation, which includes human resources and know-how as the spearhead. Challenges have to do with the generation of efficient and transparent services that provide public value and promote the benefit of society. Some implications are related to governments deciding to plan digitalization that allows them to take advantage of the emerging technological change to improve activities along the value chain.
Do Behavioural Biases Drive Adoption of Digital Banking Services? The Moderating Role of User Type
Authors: Jain Niyati , Raman T. V. , Bhardwaj Gurendra Nath
Published: July 2023

Digital banking services have gained increasing acceptance among individuals, but some people still resist using these services. Hence, it is empirical to understand the behaviour of individuals to examine the reasons behind acceptance or rejection of technology. The present study intends to analyse the role of behavioural biases in adopting digital banking services. The study included three behavioural biases: herd behaviour, risk aversion and overconfidence bias. Further, the study examined user type—early and late adopters as a moderating variable for a better understanding of the consumer’s perception. The data for the research has been collected from 411 respondents through a structured questionnaire. The proposed model has been analysed with the help of the Partial Least Squares Structural Equation Modelling approach through SmartPLS software. The findings suggest that behavioural biases, namely overconfidence bias, herd behaviour and risk aversion bias, impacted adopting digital banking services. User type—early adopters and late adopters have also proven significant in the study as the moderating variable. The study will benefit the policymakers, bankers and researchers to contemplate behavioural biases and their influence on digital banking services keeping in mind the role of user types.
Examining Evaluation Mechanism and its Impact on Brand Perception Under Colour Transformation of a Logo
Authors: Singla Vikas , Sharma Nidhi
Published: July 2023

The effectiveness of a logo in creating favourable brand perception depends on how its aesthetic and semiotic attributes are evaluated. This study examines the relationship, sequential or simultaneous, between these two evaluation parameters when a logo transforms from a single colour to multiple and vice versa. It is important to further understand how this inference influences the formation of brand perception. The objectives have been achieved by conducting two experiments. Experiment 1 involved stimuli of variation in logo redesign from six single colours to a multiple coloured logo, whereas in experiment 2, it was variation from multiple to a single-coloured logo. Results of both experiments provided opposing results with aesthetic evaluation superseding semiotic in case of single to multiple colour redesign, and vice versa for multiple to single colour transition. Further, these logo evaluation parameters showed significant mediating effect in the formation process of brand perception. This study is the first of its kind which provides a method to understand the effectiveness of logo redesign by highlighting the formation sequence of aesthetic and semiotic parameters. Comparing such sequence, especially the transformation of single to multiple colour and vice versa, would contribute significantly to the branding literature.
Communication Fiasco: Setting It Right
Authors: Pratap Vidya , Mayur Shruthi J.
Published: July 2023

After completing their daughter’s wedding ceremonies, Mala and Ravi decide to take their guests out to dinner. Mala pre-booked this get-together at Hotel Manor Residency. Mala made this booking via phone in a conversation with Kuldeep. On reaching the venue, they were informed that there is no such booking for dinner. Brushing the oversight aside, Mala and her guests settled for dinner as it had been pre-ordered. However, to the hosts’ dismay, the steward seemed to have no clue about the order. Ravi got furious at the oversight and decided to leave with his guests without having dinner. So, he wrote to the General Manager Anitha expressing his utter disappointment at how the situation had unfolded. Upon receiving the email from Dr Ravi, Anita is in a dilemma on how to tackle the situation and respond to the complaint.
Conducting Social Science Research During Epidemics and Pandemics: Lessons Learnt
Authors: Van Nuil Jennifer I. , Schmidt-Sane Megan , Bowmer Alex , Brindle Hannah , Chambers Mary , Dien Ragil , Fricke Christine , Hong Yen Nguyen T. , Kaawa-Mafigiri David , Lewycka Sonia , Rijal Samita , Lees Shelley
Published: July 2023

The COVID-19 pandemic has had a significant impact on how field-based research is being conducted globally. Given the challenges of undertaking fieldwork during epidemics and the need for mixed methods research to address the social, political, and economic issues related to epidemics, there is a small but growing body of evidence in this area. To contribute to the logistical and ethical considerations for conducting research during a pandemic, we draw on the challenges and lessons learnt from adapting methods for two research studies conducted in 2021 during the COVID-19 pandemic in low- and middle-income country (LMIC) settings: (1) in-person research in Uganda and (2) combined remote and in-person research in South and Southeast Asia. Our case studies focus on data collection and demonstrate the feasibility of conducting mixed methods research, even with many logistical and operational constraints. Social science research is often used to identify the context of specific issues, to provide a needs assessment, or inform longer-term planning; however, these case studies have shown the need to integrate social science research from the start of a health emergency and in a systematic way. Social science research during future health emergencies can also inform public health responses during the emergency. It is also crucial to collect social science data after health emergencies to inform future pandemic preparedness. Finally, researchers need to continue research on other public health issues that are ongoing even during a public health emergency.