bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of artificial neural network based mathematical models for predicting small scale quarry powder factor for efficient fragmentation coupled with uniformity index model
Authors: Taiwo B. O. , Yewuhalashet F. , Ogunyemi O. B.
Published: December 2022

Blasting powder factor is an important consideration when planning a drilling and blasting operation because it affects both the total production cost and the efficiency of downstream operations. Ten production blasts and 38 blast record datasets from a small scale dolomite quarry in Akoko Edo, Nigeria were studied to determine the effect of powder factor on blast fragmentation size distribution and uniformity index. This research evaluated the relationship between powder factor and fragmentation size distribution, as well as apply artificial neural network to model small diameter drill hole blast powder factor based on predominant controllable blast design factors. According to the research, the small scale blasting powder factor ranges between 0.6 and 1.0 kg/m3. According to the WipFrag analysis, increasing the powder factor causes an increase in the fragmentation mean size and an upward shift in the particle size distribution curve. The mine blasting operation uniformity index was also found to be between 1.3 and 1.68. The powder factor range of 0.7-0.9kg/m3 was determined by the uniformity index. The performance of the proposed ANN model was evaluated using the correlation coefficient and found to have a high prediction accuracy (R2 = 0.997). As a result, the proposed ANN models can be used to improve the blast powder factor for real-world applications.
Corticotropin-releasing Factor- Dopamine Interactions in Male and Female Macaque: Beyond the Classic Vta
Authors: Kelly E. A. , Fudge Julie L.
Published: December 2022

Dopamine (DA) is involved in stress and stress-related illnesses, including many psychiatric disorders. Corticotropin-releasing factor (CRF) plays a role in stress responses and targets the ventral midbrain DA system. This system is comprised of DA and non-DA cells and is divided into specific subregions. Although CRF inputs to the midline A10 nuclei of the DA system are well studied in rodents, in monkeys, CRF-containing terminals are also highly enriched in the expanded A10 parabrachial pigmented nucleus (PBP) and in the A8 retrorubral field subregion. In primates, the central extended amygdala, a rich source of CRF afferents across species, preferentially targets the PBP and A8 fields. We thus sought to characterize CRF terminals on DA (tyrosine hydroxylase, TH+) and non-DA (TH-) cell types in the PBP and A8 regions at the ultrastructural level using immuno-reactive electron microscopy (EM) for TH and CRF in male and female macaques. CRF labeling was present mostly in axon terminals, which mainly contacted non-DA dendrites in both subregions. Most CRF-positive terminals had inhibitory (symmetric) profiles. In the A8, CRF symmetric (inhibitory) contacts onto non-DA neurons were significantly greater than asymmetric (excitatory) profiles; this pattern was also seen in the PBP, but did not reach statistical significance. No sex differences were found. Hormonal assays suggested that our animals were at similar developmental stages and experienced similar stress levels. Together our findings suggest that at baseline, CRF terminals in the primate PBP and A8 largely regulate DA indirectly through non-DA neurons.
Accuracy requirements for the road friction coefficient estimation of a friction-adaptive automatic emergency steerassist (ESA)
Authors: Ahrenhold Tim , Jannes Iatropoulos , Roman Henze
Published: December 2022

The number of traffic accidents resulting in personal injury and property damage is increasingly beingreduced by effective advanced driver assistance systems (ADAS). Nevertheless, many traffic accidentsstill cannot be prevented today because they are due to wet, snow- and ice-covered roads. For this reason, the Institute of Automotive Engineering (IAE) of the Technical University of Braunschweigis investigating the road friction coefficient sensitivity and adaptation of advanced driver assistance systems (ADAS) currently in series production from 2018 to 2021 as part of the ‘Road Condition Cloud’ research project funded by the German Research Foundation (DFG) in order to increase driving safety,particularly on wet, snow- and ice-covered roads. In this article, the road friction coefficient sensitivityand adaptation of an automatic emergency steer assist is simulatively investigated. This assist overridesthe driver to automatically execute an evasive maneuver. The driving maneuver used is a standardizedobstacle-avoidance maneuver that is simulatively repeated on a dry, wet, snow- and ice-covered road.The road friction coefficient sensitivity shows that this test is already failed on a wet road because thesimulated vehicle does not pass the second lane without errors. Subsequently, a road friction coefficientadaptation of the emergency steer assist is investigated. This adaptation varies the maximum lateralacceleration of the evasive trajectory depending on an estimated value of the road friction coefficientin order not to exceed the maximum adhesion coefficient of the wheels during the evasive maneuver.Ideally, the estimated value matches the true road friction coefficient so that the second lane is passedwithout errors even on a wet, snow- and ice-covered road. In contrast, an existing difference determineswhether the test is passed. Finally, the necessary accuracy requirements of the road friction coefficientestimation are determined in an novel estimation error diagram. A road friction coefficient adaptationincreases the driving safety of driver advanced assistance systems (ADAS) that are in series productiontoday and future highly automated driving functions (HAF) and is necessary for automated drivingbecause the driver is not present as a fallback level.
Personalized circulating tumor DNA detection for monitoring immunotherapy efficacy in locally advanced or metastatic non-small cell lung cancer
Authors: Cheng Lei , Gao Guanghui , Zhao Chao , Wang Haowei , Yao Chao , Yu Hanchuanzhi , Yao Jichen , Li Feng , Guo Lijie , Jian Qijie , Chen Xiaoxia , Li Xuefei , Zhou Caicun
Published: December 2022

Immune checkpoint inhibitors (ICIs) or combined with chemotherapy have shown outstanding efficacy in treatment of advanced non-small cell lung cancer (NSCLC). However, efficient biomarkers for monitoring response to first-line ICIs ± chemotherapy remain unclear. In our study, 16 tumor tissues and 46 matched peripheral blood samples at baseline and during treatment from 19 locally advanced or metastatic NSCLC patients were collected. Circulating tumor DNA (ctDNA) burden by tumor-informed assay was detected to monitor and predict therapeutic response and survival of NSCLC patients treated with first-line ICIs or plus chemotherapy. We first compared the susceptibility of tumor-informed assay and tumor-agnostic assay to detect ctDNA, and found that ctDNA was only positively detected in one patient by tumor-agnostic assay with mean variant allele fraction (VAF) of 6.40%, while positively detected in three patients by tumor-informed assay with mean VAF of 8.83%, 0.154% and 0.176%, respectively. Moreover, tumor-informed assays demonstrated sensitive ctDNA detection in 93.75% (15/16) of patients. The trend of ctDNA level from baseline to first evaluation was consistent with radiographic changes. The decrease in ctDNA after treatment compared with baseline was more in patients with partial response than in patients with stable disease/progressive disease. Patients with more than 50% reduction had a significant progression-free survival and overall survival benefit. Our findings suggested that tumor-informed assay turned to be a better option for ctDNA detection, and plasma early ctDNA dynamic changes could be a valuable biomarker for monitoring efficacy and outcome prediction in advanced NSCLC patients treated with first-line ICIs ± chemotherapy.
Coupling magnetic levitation of graphene oxide-protein complexes with blood levels of glucose for early detection of pancreatic adenocarcinoma
Authors: Quagliarini Erica , Caputo Damiano , Cammarata Roberto , Caracciolo Giulio , Pozzi Daniela
Published: December 2022

Introduction
Pancreatic adenocarcinoma (PDAC) has a poor prognosis since often diagnosed too late. Dyslipidemia and hyperglycemia are considered risk factors, but the presence of the tumor itself can determine the onset of these disorders. Therefore, it is not easy to predict which subjects with diabetes or dyslipidemia will develop or have already developed PDAC. Over the past decade, tests based on the use of nanotechnology, alone or coupled with common laboratory tests (e.g., hemoglobin levels), have proven useful in aiding the diagnosis of PDAC. Tests based on magnetic levitation (MagLev) have demonstrated high diagnostic accuracy in compliance with the REASSURED criteria. Here we aimed to assess the ability of the MagLev test in detecting PDAC when coupled with the blood levels of glycemia, cholesterol, and triglycerides.
Methods
Blood samples from 24 PDAC patients and 22 healthy controls were collected. Human plasma was let to interact with graphene oxide (GO) nanosheets and the emerging coronated systems were put in the MagLev device. Outcomes from Maglev experiments were coupled to glycemia, cholesterol, and triglycerides levels. Linear discriminant analysis (LDA) was carried out to evaluate the classification ability of the test in terms of specificity, sensitivity, and global accuracy. Statistical analysis was performed with Matlab (MathWorks, Natick, MA, USA, Version R2022a) software.
Results
The positions of the levitating bands were measured at the starting point (i.e., as soon as the cuvette containing the sample was subjected to the magnetic field). Significant variations in the starting position of levitating nanosystems in controls and PDACs were detected. The combination of the MagLev outcomes with the blood glycemic levels returned the best value of global accuracy (91%) if compared to the coupling with those of cholesterol and triglycerides (global accuracy of ~77% and 84%, respectively).
Conclusion
If confirmed by further studies on larger cohorts, a multiplexed Maglev-based nanotechnology-enabled blood test could be employed as a screening tool for PDAC in populations with hyperglycemia.
Magnetothermal Effects and Critical Behavior of Rare Earth Manganese Oxides La 0.65 Ca 0.35 Mn 1-x Ni x O 3 (x=0, 0.2)
Authors: Zhao Jing , Zhao Jianjun , Jin Xiang , Yun Huiqin , Li Cheng , Hao Zhijun , Xing Ting , Ma Huaijin , Xing Ru
Published: December 2022

This study used the conventional solid-phase reaction method to prepare polycrystalline samples: La0.65Ca0.35Mn1−xNixO3 (x = 0, x = 0.2). The effects of Ni doping on the preformed cluster phases, magnetothermal effects, and critical behavior were systematically investigated. The results showed that the prepared polycrystalline samples all had cubic chalcogenide structures. The substitution of Ni2+ ions for a certain number of Mn3+ ions reduced the changes in the lattice parameters, unit cell volume, Curie temperature (Tc), magnetic entropy, and magneto-entropy. The changes in these properties originated from the partial substitution of Ni2+ for Mn3+ ions, which changed the Mn3+/Mn4+ ratio and decreased the Mn-O-Mn bond angle, thus weakening the double exchange interaction. Both samples had a preformed cluster phase above the low-temperature magnetic-transition temperature. The critical behaviors of both samples fit the tricritical model well. A transition from primary to secondary phase transition existed for both the parent and doped samples, and the maximum magnetic entropy changes of the samples at an applied magnetic field of 7 T were 7.70 J·kg− 1·K− 1 and 2.08 J·kg− 1·K− 1, respectively.
The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions
Authors: Fan Zheng , Ardicoglu Raphaela , Batavia Aashil A. , Rust Ruslan , von Ziegler Lukas , Waag Rebecca , Zhang Jing , Desgeorges Thibaut , Sturman Oliver , Dang Hairuo , Weber Rebecca , Moor Andreas E. , Schwab Martin E. , Germain Pierre-Luc , Bohacek Johannes , De Bock Katrien
Published: December 2022

The molecular mechanisms of angiogenesis have been intensely studied, but many genes that control endothelial behavior and fate still need to be described. Here, we characterize the role of Apold1 (Apolipoprotein L domain containing 1) in angiogenesis in vivo and in vitro. Single-cell analyses reveal that - across tissues - the expression of Apold1 is restricted to the vasculature, and that Apold1 expression in endothelial cells (ECs) is highly sensitive to environmental factors. Using Apold1-/- mice, we find that Apold1 is dispensable for development and does not affect postnatal retinal angiogenesis nor alters the vascular network in adult brain and muscle. However, when exposed to ischemic conditions following photothrombotic stroke as well as femoral artery ligation, Apold1-/- mice display dramatic impairments in recovery and revascularization. We also find that human tumor endothelial cells express strikingly higher levels of Apold1, and that Apold1 deletion in mice stunts the growth of subcutaneous B16 melanoma tumors, which have smaller and poorly perfused vessels. Mechanistically, Apold1 is activated in ECs upon growth factor stimulation as well as in hypoxia, and Apold1 intrinsically controls EC proliferation but not migration. Our data demonstrate that Apold1 is a key regulator of angiogenesis in pathological settings, whereas it does not affect developmental angiogenesis, thus making it a promising candidate for clinical investigation.
Lysimeter Deep N Fertilizer Placement Reduced Leaching and Improved N Use Efficiency
Authors: Rychel Katrin , Meurer Katharina H.E. , Getahun Gizachew Tarekegn , Bergström Lars , Holger Kirchmann , Kätterer Thomas
Published: December 2022

Deep fertilization has been tested widely for nitrogen (N) use efficiency but there is little evidence of its impact on N leaching and the interplay between climate factors and crop N use. In this study, we tested the effect of three fertilizer N placements on greenhouse gas (GHG) emissions, leaching, and crop growth in a lysimeter experiment over a 33-month period comprised of three years with spring-sown cereals (S1, S2, and S3) with a preceding 11-month (F1) and a subsequent 15-month (F2) fallow period. In addition to a control with no N fertilizer (Control), 100 kg N ha− 1 year− 1 of ammonium nitrate was placed at 0.2 m (Deep), 0.07 m (Shallow), or halved between 0.07 m and 0.2 m (Mixed). Deep reduced leachate amount in each period except F1, with significant reductions (p < 0.05) in the drought year (S2) and cumulatively for S1-S3. Overall, Deep reduced water flow by 22, 25 and 34% compared to Shallow, Mixed and Control, respectively. Deep and Mixed reduced N leaching across S1-S3 compared with Shallow, but Deep further reduced N loads by 15% compared to Mixed and was significantly lowest (p < 0.05) among the fertilized treatments in S1 and S2. In S3, Deep increased grain yields by 28 and 22% compared to Shallow and Mixed, respectively, while maintaining a high grain N content and nearly doubling the agronomic efficiency of N (AEN) and the recovery efficiency of N (REN). Deep N placement is a promising mitigation practice that should be further investigated.
Sublingual Recurring Extra osseous Ewing Sarcoma: A Rare Case Report and Review of Literature
Authors: Alaroomy Leena ali , Amer Hatem , Ayad Haytham , El-din Yasmine Alaa , Alwadeai Mohamed
Published: December 2022

Background: Extera skeletal (Extraosseous) Ewing sarcoma is a rare primary tumor of the soft tissue, with an extremely high mortality rate and a bad prognosis which primarily affects young individuals. It occurs without particular clinical signs and can impact several different areas, which may delay diagnosis. Histopathological examination and immunohistochemistry are crucial for making a definite diagnosis. Besides this, early diagnosis is necessary for succeeding of the management.
Case report: The objective of the present case report was to document a rare case of EES which originated from the floor of the mouth. A 37-year-old male patient came to our clinic with sublingual rapidly growing swelling. He was suffering from difficulty in opening his mouth and a feeling of dysphagia. The patient revealed during a history-taking procedure that he had undergone one surgery to remove the mass that had previously developed in the same area, knowing that he had been diagnosed in the first as a non-specific inflammatory reaction. Clinical examinations revealed a dome shape soft tissue mass. The biopsy specimen underwent histopathological and immunohistochemical analysis, which demonstrated poorly differentiated small blue round cells with positive immuno-expression of CD-99, NKX2-2, FLI-1, and Vimentin. The final diagnosis was EES based on the clinical presentation, histopathological pattern, and findings of the immunohistochemistry investigations. Radiotherapy and chemotherapy were chosen as treatment modalities for the case. Unfortunately, the patient died after three months due to the occurrence of multiple distant metastasis areas.
Conclusion: Regardless of the relative rarity of Extraosseous Ewing sarcoma, it should be taken into account as a possible differential diagnosis for intraoral soft tissue masses, and accurate diagnosis with precise histopathological and immunohistochemical evaluations should be done as soon as possible. Moreover, improvement of management procedures of such cases generally provides the best chances for patient survival.
Developing a Parenting Model for the Decent Use of Digital Media among the Teenagers in Bangladesh: A Qualitative Exploration
Authors: BakiBillah Abul Hasan , Khan Ayub , Muhammad Faisal , Chowdhury ABM Alauddin , Shahinuzzaman Md. , Hossain Syed Billal , Akram Muhammad , Almasri Nihad A. , Wani Mohammad Amin , Chowdhury Moniruddin , Kabir Russell
Published: December 2022

Background: In Bangladesh, parents are crucial in ensuring that teens use digital gadgets responsibly. The purpose of this study was to create a parenting paradigm within the context of the government's purges.
Method: Nineteen key informants took part in this study as part of the qualitative inquiry.
Results: Participants come from a variety of backgrounds and play a variety of roles that all support the same goal. The parenting model was created using the information from the interviews. By placing secondary and upper secondary educational institutions at the core of government action, parents will be educated. This approach was first proposed to be used in the "Generation Breakthrough" program of the Ministry of Education. Parents should be invited to the institutions to learn about the actions that need to be performed and followed under the two main categories, preventative and curative. Technology, the spoken word, psychology, and relationships built on evidence and trust are all examples of preventive approaches. Corrective measures include counseling, assistance with cyber security, legal services, and law enforcement.
Conclusion: In order to ensure that teens are using digital gadgets responsibly, this study suggests educating and empowering parents through a realistic strategy.
The Zambian Energy Transition (ZET): A Case Study for OsemOSYS and FlexTool
Authors: Nyoni Kumbuso Joshua
Published: December 2022

This paper presents a Zambia study case for the application of Osemosys and Flextool. Three scenarios are explored assessing Zambian energy transition outlook (2022 – 2063) which include the business as usual (BAU), integrated resource plan (IRP), and Net Zero prospects to align with agenda 2063 for Africa. The output of Osemosys simulation modelling comprises detailed results providing capacity expansion planning of the generation assets to meet the anticipated demand for a specific range of future years (2022 – 2063). Based on the performance of the energy mix (i.e., hydro, thermal and renewable energy generation projects), the simulation assesses the adequacy of the available assets and identifies new capacity to be added at the least cost. Thereafter, the flexibility of the power system is assessed using FlexTool. To contextualise, FlexTool was used to assess the flexibility of the defined specific year of the capacity expansion plans produced in Osemosys. The writeup delved into analysis of three key assessment indicators for the various scenarios which include cost-effective generation, emissions reduction, and flexibility assessment outcome.
Genetic factors inherited from both diploid parents interact to affect genome stability and fertility in resynthesized allotetraploid Brassica napus
Authors: Katche Elizabeth Ihien , Schierholt Antje , Schiessl Sarah V. , He Fei , Lv Zhenling , Batley Jacqueline , Becker Heiko C. , Mason Annaliese S
Published: December 2022

Established allopolyploids are known to be genomically stable and fertile. However, by contrast, most newly resynthesized allopolyploids are infertile and meiotically unstable. Identifying the genetic factors responsible for genome stability in newly formed allopolyploid is key to understanding how two genomes come together to form a species. One hypothesis is that established allopolyploids may have inherited specific alleles from their diploid progenitors which conferred meiotic stability. Resynthesized B. napus lines are often unstable and infertile, unlike B. napus cultivars. We tested this hypothesis by characterizing 41 resynthesized B. napus lines produced by crosses between eight B. rapa and eight B. oleracea lines for copy number variation resulting from non-homologous recombination events, and fertility. We resequenced eight B. rapa and five B. oleracea parent accessions, and analyzed 19 resynthesized lines for allelic variation in a list of meiosis gene homologs. SNP genotyping was performed using the Illumina Infinium Brassica 60K array for three individuals per line. Self-pollinated seed-set and genome stability (number of copy number variants) were significantly affected by the interaction between both B. rapa and B. oleracea parental genotypes. We identified thirteen putative meiosis gene candidates which were significantly associated with frequency of copy number variants and which contained putatively harmful mutations in meiosis gene haplotypes for further investigation. Our results support the hypothesis that allelic variants inherited from parental genotypes affect genome stability and fertility in resynthesized rapeseed.
Konsep toleransi dalam Alquran (Studi atas ¬Q.S. Al-Kāfirūn dan implikasinya terhadap pembelajaran PAI di sekolah)
Authors: Surahman Cucu , Sunarya Bayu , Yuniartin Titin
Published: December 2022

Penelitian ini mengkaji tentang kekhasan konsep toleransi yang ada dalam al-Qur’an. Sudah cukup banyak penelitian terkait hal ini, akan tetapi masih sedikit yang melihat signifikasinya dalam konteks perumusan komponen pembelajaran Pendidikan Agama Islam (PAI) di sekolah. Penelitian ini mencoba mengisi ruang kosong (lacuna) itu. Di mana penelitian ini bertujuan untuk mendeskripsikan konsep toleransi dalam Q.S. al-Kāfirūn dan implikasinya terhadap pembelajaran PAI di sekolah. Objek kajian penelitian ini adalah kitab-kitab tafsir al-Qur’an. Dengan menggunakan pendekatan kualitatif dan metode library research, penelitian ini menemukan bahwa Q.S. al-Kāfirūn telah memberikan preskripsi terkait konsep toleransi dalam Islam. Dari penelitian ini juga diketahui bahwa konsep toleransi dalam Q.S. al-Kāfirūn ini memiliki implikasi teoritis terhadap komponen pembelajaran PAI di sekolah yaitu meliputi materi dan metode pembelajaran.This study examines the peculiarities of the concept of tolerance in the Qur'an. There has been quite a lot of research related to this, but few have seen its significance in the context of formulating Islamic Religious Education (IRE/PAI) learning components in schools. This research tries to fill this empty space (lacuna) where this study aims to describe the concept of tolerance in Q.S. al-Kāfirūn and its implications forIRE/PAI learning in schools. The object of this research is the books of interpretation (kutūb al-tafāsir) of the Qur'an. By using a qualitative approach and library research method, this study found that Q.S. al-Kāfirūn has given a prescription related to the concept of tolerance in Islam. From this research it is also known that the concept of tolerance in Q.S. al-Kāfirūn has theoretical implications for the components of IRE/PAI learning in schools, which include learning materials and methods.
Students e-learning readiness towards education 4.0: Instrument development and validation
Authors: Hariyanto Didik , Yatmono Sigit , Khairudin Moh , Köhler Thomas
Published: December 2022

One of the characteristics of Education 4.0, which is a response to the demands of Industry 4.0, is the use of adaptive and artificial intelligence technologies in online education. In relation to e-learning preparedness, many researchers have conducted studies. But in Education 4.0, the teaching and learning processes' peculiarities were not considered. Therefore, this study aims to develop and validate an instrument for assessing the e-learning readiness of students toward Education 4.0. There were 126 undergraduate students participated in this study. The respondents were asked to fill out the online-based questionnaire on a voluntary basis. The data obtained were then statistically analyzed using the Pearson product-moment correlation test to measure the instrument's validity. The validity test showed that all items on the questionnaire are considerably valid at a significance level of 0.01. Meanwhile, the instrument reliability was measured through Cronbach's alpha score. The reliability test confirmed that six aspects out of seven of the instrument are categorized as high reliability (flexibility, learning preferences, project-based learning, data interpretation, improving curriculum, and self-directedness). One aspect (field experience) showed a moderate level of reliability. The study's findings confirmed that the questionnaire developed is valid and reliable for collecting data concerning the students' e-learning readiness toward Education 4.0.
Effect of adding natural zeolite and vitamin E to diets of laying hens ( Lohman Brown) on some physiological traits and productive performance during hot weather.
Authors: Alsalmany Emad H. H. , Mohammed TH. T.
Published: December 2022

This study was conducted in a poultry farm of the Department of Animal Production / College of the Agriculture/University of Anbar, from 20/7/2021 to 12/10/2021, aiming to study the effect of adding zeolite to the diets on productive performance and some physiological qualities characteristics of laying hens. Seventy-two laying hens of Lohman Brown were used in this experiment at the age of 43 weeks and distributed randomly to six treatments with four replications (3 hens/ replicate). The birds were fed with the diet with the additives, and the treatments were as follows: T1 (Vit E 0.06), T2, T3, T4 and T5 with an addition of 0.25, 0.50, 0.75 and 1.0% relay, normal zeolite and T6 control treatment.

Results showed moral differences (P≤0.05) in the egg mass, the ratio of egg production and the number of cumulative eggs for T3, T4 and T5 treatments during the productive duration of the experiment.

Keywords: natural zeolites, productive performance, heat stress, laying hens.
Effect of adding and in ovo injecting hatching eggs produced with omega-3 on some hatching traits and body weight of Japanese quail
Authors: Abdul-Razzaq Al-Aboudi Anfal Saud , Jodi Shahid Muhammad , Al-Gharawi Jassim Kassim
Published: December 2022

This study was conducted at a private hatchery in Thi-Qar Governorate to determine the effect of adding omega-3 fatty acid to quail's diet with the outcome of ovo injecting the resulting hatching eggs with omega-3 on some hatching traits and body weight of Japanese quail. A total of 540 eggs were used. The experiment treatments were as follows: T1: Negative control (without adding oil); T2: Positive control (adding 0.01% sunflower oil); T3: Feed the parent with 0.01% omega-3 oil; T4: Feed the parent with 0.01% omega-3 oil, and the resulting eggs were in ovo injected with 0.01 ml omega-3; T5: Feed the parent by 0.01% omega-3 oil, and the resultant eggs were in ovo injected with 0.01 ml sunflower; T6: Feed the parent by 0.01% sunflower oil, and the resulting eggs were in ovo injected with 0.01 ml sunflower; T7: Feed the parent by 0.01% sunflower oil, and the resultant eggs were in ovo injected with 0.01 ml omega-3; T8: Feed the parent by free diet, and the resulting eggs were in ovo injected with 0.01 ml omega-3; T9: Feed the parent by free diet, and the resultant eggs were in ovo injected with 0.01 ml sunflower. The results showed a significant improvement in T4 (the treatment whose parents were fed omega-3 and in ovo injected with omega-3 oil) compared to the control treatment on hatching rate and fertility rate of whole eggs, with a significant decrease in the percentage of embryonic mortality and pipped eggs for the hatched chicks. Feeding Japanese quail mothers with omega-3 hatching egg injections led to a substantial increase in the average weekly body weight.

Keywords: in ovo injecting, hatching eggs, with omega-3, hatching traits, body weight, Japanese quail.
Effect of flaxseed oil dosing on fertility, growth characteristics and some physical, biochemical, and hormonal blood parameters during the early pregnancy of Awassi ewes.
Authors: I.Noaman Abdullah , M.Khalaf Rafea , GH.Al-Abbasy Emad , Mohammed Th. T.
Published: December 2022

This study aims to complete the direction of experimental research in determining the effect of flaxseed oil doses on the fertility of Awassi ewes, as well as some important blood parameters to clarify the animal's physiological state during the duration of the experiment. This study was conducted in the animal field (College of Agriculture - Tikrit University) for 76 days (16 days before and 60 days after fertilization). 2-3 years have an average live weight of 51.74 kg, and the ewes were randomly divided into three treatments (each treatment was nine ewes). The three treatments were given doses of flaxseed oil at the rate of 0, 6 and 8% / kg of feed, respectively. The results showed that there was no significant difference (P≤0.05) between the treatments in the ewes' weights and physical blood characteristics during the experiment period, while it was noted that the fertility rate of the second and third treatments amounted to 66.66% for each of them, over the first treatment (55.55%). In addition, the second treatment was significantly (P≤0.05) superior in blood globulin concentration over the rest. In contrast, the third treatment was significantly (P≤0.05) superior in triglyceride concentration (62.66) mg/dL, and the first treatment showed a significant (P≤0.05) superiority. In glucose concentration (70.33) mg/dL. The following characteristics were not significantly different in total protein, albumin, urea, creatinine, ALT and AST enzymes, as well as no significant difference between treatments in the concentration of estrogen and progesterone hormones.

Keywords: flaxseed oil, Awassi ewes, fertility
Chemotherapy's impact on a few blood parameters
Authors: Al-Shibli Qasim , Jawad Al-Haidarey Mohammed
Published: December 2022

Cyclophosphamide (CP), Ifosfamide (IFO), Paclitaxel (PTX) and Doxorubicin (DOX) are commonly used cytostatic drugs. The present study investigates the ecotoxicity and genotoxicity of CP, DOX, and PTX, their human metabolites/transformation products (TPs) cyclophosphamide (NCP) as individual compounds and as a mixture. The three-parent compounds ( Further ecotoxicity studies of metabolites. The measured toxicity of the cross was lower than the toxicity predicted by the concentration addition model indicating potentiating effects of the CPCOOH toxicity. Revealed genotoxic activity of CP and the mixture in the presence The degradation study with UV irradiation of samples containing (CP, cyclo, and DOX ) showed efficient degradation of compounds and remained toxic. They are suggesting that no stable with adverse effects was formed. This is the first study describing the ecotoxicity and genotoxicity of the commonly used cytostatics CP, cyclo, and DOX, their known metabolites, and their mixture. The results indicate the importance of toxicological evaluation and monitoring drug metabolites as they may be more hazardous to humans than parent compounds.

Keywords. Paclitaxel. Doxorubicin. Cyclophosphamide. toxicity
Disinformation of qualitative content analysis of user-generated online content about food and the COVID-19 discussed on Sina Weibo (Preprint)
Authors: Huang Chunmei , Yang Ling , Fang Bing , Ji Chen , Zhang Wenjing , Regmi Aksara , YAMAGUCHI YOSHIFUMI , Cai Yuyang
Published: December 2022

BACKGROUND

This study focused on the online disinformation about taking food or supplements to prevent and treat Coronavirus disease (COVID-19) on Sina Weibo（the Chinese largest new media microblog platform) during the first COVID-19 lockdown.

OBJECTIVE

In this study, we aim to investigate the disinformation of taking food or supplements to prevent and treat COVID-19 on Sina Weibo.

METHODS

We searched for relevant posts from February 20, 2020 to May 06, 2020through text mining techniques to identify those containing content of “ food or supplements could prevent the COVID-19”.In addition, the descriptive research was used to analyze disinformation datasets.

RESULTS

Of the 6601 original posts that were crawled from Weibo, we identified 2989 (45.28%) informative posts that spread false information about food or supplement by manual screening. The most frequent disinformation include Vitamin C(25.36%), garlic(22.38%), salt water gargle(14.32%), drinking more tea(12.98%), smoked vinegar(9.84%), onions(7.19%), drinking high alcohol(4.65%) could prevent or kill the COVID-19, the least frequent: sesame oil(1.81%), ginger(1.17%), brown sugar and boiled water with ginger, onion and garlic(0.3%) could prevent the COVID-19.

CONCLUSIONS

Spreading false information that food or supplements could prevent the COVID-19 seriously affected people's daily eating habits. The diet disinformation was wrapped in a pseudoscientific shell that make it difficult for the ordinary without professional knowledge to identify it.
Digital Phenotyping: Data-Driven Psychiatry to Redefine Mental Health (Preprint)
Authors: Oudin Antoine , Maatoug Redwan , Bourla Alexis , Ferreri Florian , Bonnot Olivier , Millet Bruno , Schoeller Félix , Mouchabac Stéphane , Adrien Vladimir
Published: December 2022

UNSTRUCTURED

The term “digital phenotype” refers to the digital footprint left by patient-environment interactions. It has potential for both research and clinical applications but challenges our conception of health care by opposing 2 distinct approaches to medicine: one centered on illness with the aim of classifying and curing disease, and the other centered on patients, their personal distress, and their lived experiences. In the context of mental health and psychiatry, the potential benefits of digital phenotyping include creating new avenues for treatment and enabling patients to take control of their own well-being. However, this comes at the cost of sacrificing the fundamental human element of psychotherapy, which is crucial to addressing patients’ distress. In this viewpoint paper, we discuss the advances rendered possible by digital phenotyping and highlight the risk that this technology may pose by partially excluding health care professionals from the diagnosis and therapeutic process, thereby foregoing an essential dimension of care. We conclude by setting out concrete recommendations on how to improve current digital phenotyping technology so that it can be harnessed to redefine mental health by empowering patients without alienating them.
The Effect of Diatomaceous Earth Addition on CBR Values of Glee Geunteng Soil in Aceh Besar, Aceh Province, Indonesia
Authors: Chairullah Banta , Sungkar Munira , Ritonga Muhammad Ghiffari
Published: December 2022

The soil which is the platform often used for construction activities needs the strength to resist loads. However, its physical and mechanical properties are sometimes naturally limited and this implies there is a need for improvement and stabilization. Therefore, this study uses diatomaceous earth, which is a natural pozzolanic material classified as a type of Supplementary Cementing Materials (SCM), as an additive. The chemical stabilization was conducted by mixing the soil with stabilizing materials such as cement, lime, fly ash or others that have the ability to change the chemical composition and combination of soil. It is important to note that diatomaceous earth has similar properties as other pozzolanic materials such as fly ash and metakaolin powder and this is the reason it is expected to function as a soil stabilizing agent needed to improve soil properties. This study was conducted using the soil from Glee Geunteng in Peukan Bada as well as the diatomaceous earth obtained from Lambeureunut Village, Aceh Besar Regency, Aceh Province, Indonesia. The main purpose was to determine the California Bearing Ratio (CBR) value of the Glee Geunteng soil mixed with diatomaceous earth at 5, 10, 15, and 20% dry weight of the soil. The CBR test consisted of unsoaked CBR, soaked CBR testing at 4 days, and swelling properties of CBR with a variety of diatomaceous earth mixtures. Glee Geunteng soil was classified as A-6 Group Index 3 based on the AASHTO soil classification and as the SC (silty clay) soil according to the USCS classification. The results showed that the unsoaked CBR value reduced from 35.96% for the natural Glee Geunteng soil to 31.65% for the soil mixed with 20% diatomaceous earth material. A similar trend was observed for the soaked CBR value with a reduction from 15.57% to 6.98%. The decrease in CBR value was perceived to be caused by the very small silica content (SiO2 ) in diatomaceous earth material with 42.09% compared to the 86% in the material obtained from another source in the previous research by Hidayati.
Effect of Use Sugarcane Bagasse Ash and Rubber Tyre as A Partial Replacement of Cement and Coarse Aggregate in Concrete
Authors: Aravind V , Raj R. Prithivi
Published: December 2022

Abstract: Recycling and usage of waste products can be a viable option in the waste management of many materials. The present study focuses on the utilization of Sugarcane Bagasse Ash(SCBA) as replacement material for cement and rubber tyre as replacement material for coarse aggregate in concrete production. Noting the increasing volumes and difficulty in the disposal of wastes from rubber tyres and SCBA, this paper discusses test results of use of SCBA and recycled tyres in concrete for possible application in the construction industry. Sugarcane Bagasse ash contains high amorphous silica content and aluminium ion. For experimental investigations, Sugarcane bagasse ash and its chemical properties are obtained from Sakthi sugars private ltd, Aapakoodal, Tamilnadu. Ordinary Portland cement was partly replaced by sugarcane bagasse ash in the ratio of 0%, 10%, 20% and 30% by weight. The results indicate that inclusion of Sugarcane Bagasse Ash in concrete up to 20% level significantly enhanced the strength of concrete. In 2008, around one billion end-of-life tyres (ELTs) were being produced globally each year. As a possible means of disposing the tyres, it is proposed to use rubber tyres as coarse aggregate in concrete. Tyres cut into pieces with maximum size of 20 mm to use as coarse aggregate.It were used in the replacement of 15% of the normal gravel. Grade of concrete used in this paper is M30.Compressive strength, splitting tensile, and flexural strength tests were conducted according to the various BS codes. This paper also demonstrated the variation in the compressive strength of the non-conventional concrete when the BS and ACI methods are used in the design of the mix.
How kidneys work? Developing of Android-based Adobe animate media for senior high school students
Authors: Prasetyo Indrawan , Rofieq Ainur , Sukarsono S. , Permana Tutut Indria
Published: December 2022

Media is one of the determining factors for learning success which can accommodate student critical thinking. Moreover, during the COVID-19 pandemic, learning media became crucial in online learning. This study aims to produce and test the feasibility of android-based media on kidney material developed through Adobe Animate CC software. In addition, it also to find the effectiveness of the media in improving the critical thinking skills of eleventh graders students when used in online learning. Borg & Gall's model was used in this research and development but was limited to the seventh stage. Data collection techniques used interviews, validation (media and material experts), and test. The instruments used are interview sheets, validation sheets, response questionnaires, and essays (five critical thinking questions). The test subjects were 15 senior high school students in Bantur, East Java, Indonesia. The validation results from media and material experts show that the media is "very feasible" to use. Teachers and students stated that the media was "very practical" in online learning. There is a significant difference between students' critical thinking skills before and after using the media, t(14) = 5.65, p < 0.001. The study finding becomes the basis for continuing the process of media dissemination.
Learning history through web scraping and Tableau public: Is it possible?
Authors: Nursiyono Joko Ade , Meivita Peni
Published: December 2022

Learning history has a central role in cultivating patriotism and nationalism value for students. Various countries have placed historical education as a crucial part of national education. It is due to the belief that historical education materials can develop the nature and character of the nation's young generation. Technological developments make it easier for us to create innovative media, such as web scraping. Learning history with proper media can foster students' motivation to understand the content, such as the names and roles of national heroes. Web scraping is used to collect data from sites related to 60 national heroes and their places of birth. The data is then processed and visualized in Tableau Public. The result shows that the learning media can be categorized as good (53%). The respondent stated that the history learning media is very useful (67%). Meanwhile, regarding the effectiveness of the linkage feature between the data in the visualization, all respondents stated is good.
Los contactos cuentan: experiencias y estrategias laborales de actores y actrices de la Ciudad de México
Authors: Jaramillo-Vázquez Alejandra
Published: December 2022

Este artículo examina el papel que el origen social y los contactos juegan para el acceso a oportunidades laborales de los actores y actrices de teatro de la Ciudad de México. El estudio adoptó una metodología cualitativa y se condujeron entrevistas semiestructuradas en línea a 21 actores y actrices de teatro cuyo rango de edad es de 25 a 38 años y son residentes de la Ciudad de México. Los hallazgos señalan que tener contactos y adscribirse a una figura reconocida es una de las estrategias para el acceso a oportunidades laborales y el crecimiento de una carrera profesional, aunque consideran que el origen social y lugar de formación profesional influyen en la desigualdad laboral. Se concluye que para generar condiciones laborales dignas y derechos laborales dependerá de la implementación de políticas públicas con un enfoque de igualdad.
Variational Quantum Simulation of Valence-Bond Solids
Authors: Huerga Daniel
Published: December 2022

We introduce a hybrid quantum-classical variational algorithm to simulate ground-state phase diagrams of frustrated quantum spin models in the thermodynamic limit. The method is based on a cluster-Gutzwiller ansatz where the wave function of the cluster is provided by a parameterized quantum circuit whose key ingredient is a two-qubit real XY gate allowing to efficiently generate valence-bonds on nearest-neighbor qubits. Additional tunable single-qubit Z- and two-qubit ZZ-rotation gates allow the description of magnetically ordered and paramagnetic phases while restricting the variational optimization to the U(1) subspace. We benchmark the method against the J1−J2 Heisenberg model on the square lattice and uncover its phase diagram, which hosts long-range ordered Neel and columnar anti-ferromagnetic phases, as well as an intermediate valence-bond solid phase characterized by a periodic pattern of 2×2 strongly-correlated plaquettes. Our results show that the convergence of the algorithm is guided by the onset of long-range order, opening a promising route to synthetically realize frustrated quantum magnets and their quantum phase transition to paramagnetic valence-bond solids with currently developed superconducting circuit devices.
Mensajería instantánea móvil (MIM) y el comportamiento del consumidor Post-Millennial: oportunidades para el marketing de empresas detallistas
Authors: Canossa-Montes de Oca Héctor
Published: December 2022

Este artículo tiene como objetivo examinar la influencia del uso de la mensajería instantánea móvil (MIM) en el comportamiento del consumidor posmilenial en las empresas detallistas. Se realiza un diseño de investigación cuantitativa no experimental con alcance correlacional-causal y para el análisis empírico se utilizan modelos de ecuaciones estructurales (PLS-SEM). Como resultado principal en el estudio se identificó que las comunicaciones de marketing mediante la MIM influyen en la satisfacción y que estas, junto con la influencia de otros consumidores y la satisfacción, afectan la lealtad del consumidor posmilenial; por lo tanto, con nuevas evidencias del uso de la MIM en marketing, las empresas detallistas pueden orientar sus acciones estratégicas.
Primeras páginas
Authors: Revista Nacional de Administración UNED
Published: December 2022

Revista Nacional de Administración
The Correlation between Task Commitment and Students’ EFL Learning Achievement
Authors: Nurrahman Jihat , Hodairiyah  , Budiyono Fajar
Published: December 2022

This research aims to prove whether there is a correlation between task commitment and students’ EFL Learning achievement on reading comprehension of the second-semester students of the Indonesian Language and Literature Education Study Program. This study used eleven questionnaire items of task commitment and learning achievement tests on giving and responding opinions. The sample of this research was 30 out of 165 students. Based on the calculation results using rser correlation, the correlation value of this study was 0.129. The correlation value was very low (almost uncorrelated) according to the interpretation table of the r value. A conclusion can be drawn that the task commitment, as one of the students’ internal factors, did not affect the students’ learning achievement.