bluuebunny/crossref_metadata_2025 huggingface dataset:
TSA-1-C4 plus Tc24-C4 recombinant protein stimulation induce immunomodulatory activity by activation of macrophages
Authors: Dzul-Huchim Victor , Alfaro-Chacón Andrea , Novelo-Sarabia Patricia , Rosado-Vallado Miguel , Cruz-Chan Julio , Euan-Canto Antonio , Torres-Romero Julio , Gusovsky Fabian , Ortega-Lopez Jaime , Hotez Peter , Bottazzi Maria Elena , Villanueva-Lizama Liliana , Arana-Argáez Vctor
Published: March 2023

Chagas disease is a chronic infection caused by Trypanosoma
cruzi. The first-line drugs approved for treatment have several
limitations and are associated with toxicity. The recombinant TSA-1-C4
and Tc24-C4 proteins have been profiled as promising candidates for the
formulation of therapeutic vaccines, leading us to propose them in
combination as a bivalent recombinant protein strategy. In this study,
we evaluated the immunomodulatory effect of TSA-1-C4 plus Tc24-C4
recombinant protein combination by in-vitro assays. Macrophages
from naïve BALB/c mice were isolated and stimulated with
TSA-1-C4+Tc24-C4 proteins, supernatants were recovered to measure NO, H
O , and, TNF-α, IL-1β, IL-6 and IL-10
cytokines. Stimulated macrophages were co-cultured with CD8
T cells from naïve mice, and inflammatory
cytokine-profile was measured from supernatants. Additionally, by
experimental T. cruzi acute infection model, cytotoxicity was
evaluated in mice after the treatment with TSA-1-C4+Tc24-C4 proteins in
presence of a TLR-4 agonist adjuvant, E6020-SE. We observed that the
bivalent recombinant protein strategy activates macrophages by NO and H
O production, also induced a
significant Th1 immune-response compared to either TSA-1-C4 or Tc24-C4
stimulated macrophages. Moreover, naïve CD8 T cells
in presence of TSA-1-C4+Tc24-C4 stimulated-macrophages similarly boosted
Th1 profile by significant production of IFN-γ and TNF-α cytokines.
These results support the synergistic effect of the bivalent recombinant
protein strategy, which leads activation of peritoneal macrophages and
CD8 T cells eliciting the Th1 immune response.
Although the administration of TSA-1-C4+Tc24-C4+E6020-SE showed
cytotoxic activity in T. cruzi-infected mice, there was not a
benefit compared to stimulate with TSA-1-C4 or Tc24-C4 antigens
formulated with E6020-SE adjuvant.
The structural characteristics and driving mechanism of collaborative innovation network for saline-alkali land development in China
Authors: Yanmei Wang , Yusheng Chen , Zhaofa Sun , wenjie Sun
Published: March 2023

It is challenging for a single development subject to complete complex
scientific research tasks due to the peculiarities of saline-alkali
land. Collaborative innovation and cooperation between development
subjects are increasingly vital. This paper first constructs an
undirected weighted collaborative innovation network from the upstream,
midstream, and downstream levels of technological innovation for
saline-alkali land development, analyzing the network’s structural
characteristics and spatial distribution features. Then uses ERGM to
explore the internal and external driving mechanism for network
formation from network self-organization, subject characteristics, and
exogenous environmental factors. The results demonstrate that the
distribution of collaborative innovation networks for saline-alkali land
development is relatively uniform. However, there are also clusters, and
the clusters are mostly centered on universities and scientific research
institutions. Both the development subjects and clusters present
regional features. Centrality and transitivity are crucial in the
internal driving mechanism. In the external driving mechanism, the
Matthew effect is modest, and the Homozygous effect is considerable;
Organizational and technical proximity play a positive role;
Geographical and institutional proximity play a blocking role. This
study also provides practical enlightenment for encouraging horizontal
and vertical collaborative innovation of sustainable development of
saline-alkali land.
Cumulative Risks and Non-Suicidal Self-Injury in Adolescents: Protective Effect of Personality Strengths
Authors: Zhao HaiYan , Zhou AiBao , Chi HaiXia , Zhao JinGuo , Xia RuiXue , Pan Chaochao
Published: March 2023

Non-suicidal self-injury is an important public health problem, which is
closely related to suicidal behavior and has attracted wide attention
from researchers. This study recruited 1207 adolescents to
systematically explore the relationship between cumulative risks and
non-suicidal self-injuries using scales and questionnaires. It also
compared the influences of various risk factors on self-injurious
behaviour and researched the protective effect of personality strengths
(mindfulness, hope, openness, grit, and meaning in life) as resilience
factors. The results showed that the significant predictive effects of
cumulative risks on adolescents’ non-suicidal self-injury and adverse
childhood experiences are greater predictors of adolescents’
non-suicidal self-injury than negative life events. Mindfulness and
meaning in life are two protectors co-moderating the effects of
cumulative risk on adolescents’ non-suicidal self-injury. This study has
important implications for a better understanding of resilience. And
more intervention and prevention strategies based on personality
strengths for individuals experiencing adversity and stress could be
effective in improving their psychosocial functioning.
Formal initiatives to improve teaching led to more significant informal conversations and increased sharing practice
Authors: Eidesen Pernille , Førland O. T. K. , Håkansson L. M. , Christiansen H. H. , Dahl T. , Strømseng E.
Published: March 2023

University teachers grow professionally from conversations about
learning and teaching with colleagues. Significant informal
conversations can be facilitated through formal activities initiated
from the institutional side. This case-study shows how a formal
institutional initiative to enhance educational quality has facilitated
more significant informal conversations. Such conversations power
constructive feedback to the organisation, improve the formal quality
development work at the institutional level, and increase the use of
collegial experiences across the institution. We identify the formal
initiative “Collegial sharing sessions” as particularly efficient for
fuelling significant informal conversations within and across
departments
DNA methylation regulates Vip3Aa resistance in fall armyworm (Spodoptera frugiperda)
Authors: Zou Luming , Liu Zhenxing , Jin Minghui , Wang Peng , Shan Yinxue , Xiao Yutao
Published: March 2023

Vegetative insecticidal proteins (Vips) are widely used in pest
management, but Vip resistance is a big threat. DNA methylation plays
important roles in regulating the response of biological organisms to
environmental stress. In this study, DNA methylation map was developed
for fall armyworm (FAW, Spodoptera frugiperda), and its function in
regulating FAW Vip3Aa resistance was explored. FAW was screened by
Vip3Aa for 10 generations, and bioassays indicated that Vip3Aa
resistance increased trans-generationally. Based on the comparison of
DNA methylation maps between Vip3Aa-resistant and -susceptible strains
showed that gene body methylation was positively correlated with its
expression. Moreover, the study demonstrated that a reduction in the
methylation density within the gene body of a 3’5’-cyclic nucleotide
phosphodiesterase gene resulted in decreased expression and increased
resistance of FAW to Vip3Aa, which was validated through RNAi
experiments. The mechanism of Vip3Aa resistance will improve the
understanding of DNA methylation and its function in lepidoptera and
provide a new perspective for making strategies to pest management.
Nonlinear sequential fractional boundary value problems involving generalized ψ-Caputo fractional derivatives
Authors: Dien Nguyen
Published: March 2023

This paper is devoted to study the nonlinear sequential fractional boundary
value problems involving generalized ?-Caputo fractional derivatives with
nonlocal boundary conditions. We investigate the Green function and some of
its properties, from which we obtain a new Lyapunov-type inequality for our
problem. A lower bound for the possible eigenvalues of our problem is
derived. Furthermore, we apply some properties of the Green function to
obtain some existence results for our problem. It is worth mentioning that
our results still work with some source functions including singularities.
On matrix polynomials L(m,δ,λ)n (x)
Authors: Jatav Vinod , Shukla A.K.
Published: March 2023

The aim of this paper is to introduce matrix polynomials L(M,?,?) n (x) and establish some properties viz, hypergeometric representation, generating matrix relations, integral representations, recurrence relations, summation formulas, series relation, fractional integral and derivative operators.
Reverse order law for the core inverse of a product of two complex matrices
Authors: Li Tingting
Published: March 2023

In this paper, the necessary and sufficient conditions for the reverse order
law (AB) #O = B#OA#O are established. In addition, the hybrid reverse order
laws (AB)? = B#OA#O and (AB)# = B#OA#O are also considered. Text of the
abstract.
EP elements, partial isometries and solutions of some equations
Authors: Gadelseed Bakri , Wei Junchao
Published: March 2023

In this paper, we firstly present new charactrizations of EP elements,
partial isometries. Next, we investigate the general solutions of some
equations. Finally, we discuss the relation between the consistency of
certain equations and SEP elements.
Baire bijections of extreme points generated by small-bound isomorphisms of simplex spaces
Authors: Rondos Jakub , Spurný Jiří
Published: March 2023

We show that small-bound isomorphisms of spaces of affine continuous
functions on Choquet simplices with Lindel?f boundaries induce Baire
measurable bijections of their sets of extreme points.
Some observations on the mildly Menger property and topological games
Authors: Bhardwaj Manoj , Osipov Alexander
Published: March 2023

In this paper, we defined two new games - the mildly Menger game and the
compact-clopen game. In a zero-dimensional space, the Menger game is
equivalent to the mildly Menger game and the compact-open game is equivalent
to the compact-clopen game. An example is given for a space on which the
mildly Menger game is undetermined. Also we introduced a new game namely
K-quasi-component-clopen game and proved that this game is equivalent to the
compact-clopen game. Then we proved that if a topological space is a union
of countably many quasi-components of compact sets, then TWO has a winning
strategy in the mildly Menger game.
Two-step laser cladding of Inconel 625 on copper
Authors: Leunda Josu , Sanz Carmen , Cejuela Marcos
Published: March 2023

Copper is widely used in many industrial applications although its poor mechanical properties limit its use. Nevertheless, nickel-based alloys offer high wear resistance that applied on copper as surface coating could overcome this lack. The direct application of coatings with laser technologies on a copper substrate presents difficulties due to the poor absorption of this metal in the usual wavelengths of lasers, and this study is focused precisely on solving them. The results of the two-step laser cladding of Inconel 625 on the copper substrate are analyzed in terms of microstructure, chemical analysis, and hardness. Moreover, the metallurgical bonding of (Cu and Ni) solid solution between the direct laser cladding coating of the Ni alloy and copper is studied as well as the absence of interfacial cracks and pores under specific process parameters. This bond is assured by the high dilution and the presence of 27 wt. % of copper. The second functional Inconel 625 layer shows a dendritic microstructure with a γ-Ni matrix and Mo- and Nb-rich precipitates in the interdendritic regions with no trace of copper.
Pragmatic Awareness of Speech Acts, Politeness, and Grice Maxims of Iraqi EFL Postgraduate Students
Authors: Yousif Abdulateef Rana , Najim Abd Ali Hanan
Published: March 2023

This study examines postgraduate students’ awareness of pragmatic aspects, including Grice Maxims, Politeness, and Direct and Indirect forms of speech. According to Paul Grice’s theory of implicature, which is considered one of the most important contributions to pragmatics, this paper discusses how postgraduate students can meet the cooperative principle when communicating effectively. It also outlines how does politeness principles influence obeying or violating the maxims and how is the use of direct or indirect forms of utterances prompted by politeness. Sixteen master’s students of Linguistics and Literature were asked to take a multiple-choice test. The test will be represented along with the interpretation of each option given in each item. The initial point that the study investigates if belonging to two different groups (Linguistics and Literature) will result in various performances; this will be supplied with a clear-cut answer in the practical part. The theoretical part summarizes a literature review of the discoursal aspects understudy. In addition to clarifying maxims of quality, quantity, relation, and manner, the theoretical part discusses direct and indirect speech and how indirect speech is used to communicate perlocutionary effects. The conclusion will summarize the whole study by drawing upon the theoretical and practical parts simultaneously and providing further reasons for the variability and choice of one option over another.
Crisis, Ψ-trauma, refugees
Authors: Christinaki Artemis
Published: March 2023

Since 2014 the situation in the Mediterranean Sea has been named and tackled as a ‘refugee crisis’, and in the name of this ‘crisis’ migrants have been accommodated in ‘hotspots’ and camps. Within these spaces, their experiences have often been articulated by the humanitarian sector and the discipline of psychology as traumatic, with refugees being described as traumatised. In this article, I critically discuss the politics of psychology and trauma within the European territory of aid, with a specific focus on Greece, amid the current, so-called ‘refugee crisis’. I start by situating crisis and trauma as concepts and their role within humanitarian and state governance. I continue by discussing how the terms ‘hotspot’ and ‘camp’ emerged in state and humanitarian discourse and practice, to explore then the politics of psychology and trauma there. Both space and time are important elements for understanding the role of psychology, as they comprise the material landscape of migration amid ‘refugee crisis’. At the same time, the discourses of psychology and trauma are implicated in the very production of these spaces. Approaching critically their interconnection through the lens of critical psychology and the work of Frantz Fanon, the article concludes that the gaze of humanitarian aid and psychology, besides medicalising refugees, psychologises the inherently political issues of migration and life lived in hotspots and camps. In so doing, it substitutes the latter with a managerial discourse.
Politics of the body in the 'woman, life, freedom' movement in Iran
Authors: Kohan Mehr-Afarin
Published: March 2023

On 16 September 2022, nationwide protests broke out in Iran in reaction to the death of a 22-year-old girl, Mahsa Amini, who was killed by the morality police for not wearing a ‘proper hijab’ and led to the first women-led movement in Iran. This commentary explores the importance of this movement and historical moment as it relates to the form of resistance that is being exercised in fighting against the oppression of women under the current gender apartheid of the Islamic Republic. I examine the main slogans, symbols, and icons of this movement in the context of the politics of the body and a reclaiming of women’s bodies in a fight against a patriarchal dictatorship.
Freud on war and violence
Authors: Pavón Cuéllar David
Published: March 2023

This article analyses Sigmund Freud’s reflections on war and violence, especially in his two main works on this issue: Thoughts for the Time of War and Death (1915) and Why War? (1932). After presenting these two essays and placing them in their historical contexts, I briefly review what authors have written about them in recent years. I then attempt to contribute something new to the discussion by examining four of Freud’s propositions: his justification for disillusionment caused by war; his suspicion about peoples and states; his denunciation of the primitivism and hypocrisy of human beings; and his determination to maintain hope in culture and history. I consider these key points of Freud’s essays separately, showing their importance for Freud’s social theory and for his critique of modernity and civilisation in general.
Mütareke Dönemi’nde İstanbul’da Arnavud Teâvün Cemiyetinin Kuruluşu ve Faaliyetleri
Authors: YAVAŞ Mesut
Published: March 2023

Osmanlı Devleti’nin Mondros Mütarekesi ile savaştan çekilmesinden kısa bir süre sonra İstanbul’daki Arnavut aydınlar, Arnavutlar arasında birlik ve beraberliği tesis etmek, yardımlaşma ve dayanışmayı sağlamak için teşkilatlanmaya gitmişler ve “Arnavud Teâvün Cemiyetini” kurmuşlardır. İstanbul merkezli Cemiyet, kuruluş amacını Arnavutluk’un hukukunu savunmak, Arnavutluk sınırları dışında kalan ülkenin diğer kısımlarının anavatana katılmasına çalışmak ve ihtiyaç sahiplerine yardım etmek olarak belirlemiştir. Bu çerçevede siyasi, kültürel, eğitim, vb. alanlarda faaliyetlerde bulunmuştur. Bu çalışmada Mütareke Dönemi’nde İstanbul’da kurulan Arnavud Teâvün Cemiyeti ele alınmıştır. Bu kapsamda Cemiyetin kuruluş aşaması, şube ağını genişletme çalışmaları; siyasi, kültürel ve eğitim alanındaki faaliyetleri incelenmiştir. Sadece Osmanlı Hükümetinin değil, aynı zamanda Millî Mücadele’nin merkezi Ankara’nın da Cemiyetin faaliyetlerine yönelik hassasiyeti tespit edilmeye çalışılmıştır. Çalışmada ayrıca Arnavutların bu dönemde İstanbul’da kurdukları diğer cemiyet ve derneklere de değinilmiştir. Tüm bunlar başta arşiv belgeleri olmak üzere dönemin basını ve ikinci el kaynaklar üzerinden ortaya konulmaya çalışılmıştır.
The Relationship between Family and Community Resilience during the Developmental Transition of Emerging Adulthood
Authors: Garcia Elisabeth Ponce , McNeill Charleen , LCSW Grace Whaley , Rohli Robert V , Garrison M. E. Betsy
Published: March 2023

Resilience – the ability of a dynamic system to withstand, or adapt to, threats or risk to its stability, viability, or development – is an important component of environmental, economic, and social systems. While resilience has been studied extensively from individual-, family-, and community-level perspectives, substantially less work has been devoted to understanding resilience through a lens that crosscuts system levels so that an integrated model of resilience can be developed. This research aims to address this gap by identifying a link between family and community resilience as reported by 593 emerging adults. Results support the hypothesis that family resilience predicts community resilience during the transition to adulthood. The results support the proposed framework presented by Houston (2018) in which community resilience is positioned well for both top-down and bottom-up comparisons. The results are also consistent with the dynamic systems perspective which posits that resilience occurs as a result of interactions between and within the levels of complex systems to include the individual, family, and community. These results assist in understanding mechanisms by which resilience emerges from internal and external interactions between and within levels of each system and across developmental transitions.
incidência de prematuros em mulheres portadoras de diabetes mellitus gestacional em uma Maternidade do Norte Catarinense
Authors: Marini Iasmin , Alcântara Sarah Bernadette de Carvalho , Balem Luana
Published: March 2023

Diabetes Mellitus Gestacional (DMG) é uma patologia com início na gestação que traz alterações no organismo e no metabolismo materno e fetal, sendo uma delas a indução prematura do parto, gerando consequências para a mãe e para o Recém-Nascido (RN). O objetivo desta pesquisa foi analisar a incidência da prematuridade em bebês de gestantes portadoras de DMG em uma maternidade do norte catarinense entre 2020 e 2021, além de caracterizar os recém-nascidos quanto à Idade Gestacional (IG), internamentos em Unidade de Terapia Intensiva (UTI) e seus diagnósticos. Foi realizada uma pesquisa retrospectiva, por amostragem simples, através da coleta de dados em prontuários e tendo como critérios de inclusão gestantes portadoras de DMG que tiveram RN prematuros, assim como os prematuros filhos de mães com DMG. Constatou-se que 2,5% das gestantes atendidas apresentaram DMG, e a incidência de parto prematuro foi de 31,5%. A IG variou de 33 semanas até 36 semanas + 5 dias e 60% dos recém-nascidos foram classificados com peso adequado para a IG. Metade dos bebês prematuros foi para UTI, tendo como diagnósticos icterícia neonatal, desconforto respiratório, hipoglicemia. Portanto, o presente estudo revela que há relação entre DMG e prematuridade, indo ao encontro das evidências científicas disponíveis. Quanto aos internamentos em UTI, foi possível perceber que os diagnósticos mais encontrados foram relacionados à imaturidade dos sistemas do RN. Além destes fatores, não foi constatado óbito relacionado à DMG. Deste modo, reitera-se a necessidade do diagnóstico e rastreio precoces da DMG para prevenir possíveis consequências negativas ao neonato.
El Internet de las Cosas Médicas (IoMT): Una Revolución Tecnológica aplicable a la Gestión de la Diabetes Mellitus Tipo 1
Authors: Rodríguez Rodríguez Ignacio , Rodríguez José-Victor , Campo Valera María
Published: March 2023

La diabetes mellitus de tipo 1 (DMT1) es una afección metabólica caracterizada por una hiperglucemia persistente como consecuencia de una síntesis pancreática insuficiente de insulina. Esto obliga a los pacientes a ser conscientes de sus oscilaciones diarias del nivel de glucosa en sangre para deducir un patrón y anticipar la glucemia futura y, por tanto, decidir la cantidad de insulina que debe inyectarse exógenamente para mantener la glucemia dentro del intervalo objetivo. Este enfoque suele adolecer de una imprecisión relativamente alta, que puede resultar peligrosa. Sin embargo, los recientes avances en las tecnologías de la información y la comunicación (TIC) y los innovadores biosensores que podrían permitir una evaluación completa y en tiempo real de la salud del paciente ofrecen un nuevo punto de vista sobre el tratamiento de la DMT1. En este sentido, las tecnologías disruptivas emergentes como Big Data, Internet de las Cosas Médicas (IoMT), Cloud Computing y Machine Learning (ML) pueden desempeñar un papel importante en la gestión de la DMT1. En este trabajo, se realiza una explicación de los enfoques basados en IoMT publicados anteriormente para la gestión de la diabetes, evaluando también los obstáculos que los futuros sistemas inteligentes de gestión IoMT deben superar. Por último, proporcionamos una visión general de una propuesta integral basada en IoMT para la gestión de la DM1 que pretende abordar los límites de los estudios anteriores y, al mismo tiempo, utilizar las tecnologías disruptivas destacadas anteriormente.
AF641, AI954 and AW954 antibodies label the endoplasmic reticulum by immunofluorescence
Authors: Herren Margaux , Leyss Simon , Liborova Karolina , Maître Marie , Manghetti Livia , Mencier Lucie , Moudarres Lana , Najand Gaelle , Roch Laura , Ruetsche Audrey , Schwitzguebel Valerie , Seddiki Wissem , Soulie Paola , Anagbogu Nneka , Bennani Kenza , Brun Elise , Butterworth Hannah , Carry Jennifer , Dawit Soyan , Diep Meg-Mai-Ly , Ferrillo Odyssee , Guertler Maxime , Gureu Catalina , Prodon François , Durual Stéphane , Jauslin Tania , Guilhen Cyril
Published: March 2023

The AF641, AI954 and AW954 recombinant antibodies detect different markers of the endoplasmic reticulum by immunofluorescence in HEK293 cells.
МІЛІТАРНИЙ ГЕРОЙ У РЕЦЕПЦІЇ ПОЕТІВ «ПРАЗЬКОЇ ШКОЛИ»
Authors: МАЛІЦЬКА Анна
Published: March 2023

У статті досліджено образ мілітарного героя в поетичній творчості митців «Празької школи» на матеріалі творів з антології «Стилет і стилос. Українська мілітарна поезія». Мета роботи – характеристика причин з’яви образу мілітарного героя й класифікація його основних рис. Відповідно до поставленої мети у статті розглянуто дискусійні погляди вітчизняних літературознавців (Д. Донцов, М. Ільницький, В. Просалова та ін.) на феномен цілісності «пражан» як групи. Доведено, що, попри радикальне заперечення цього феномену деякими науковцями, можна кваліфікувати звернення до образу мілітарного героя як точку перетину для представників угруповання. У наведених поезіях висвітлено й проаналізовано коло основних проблем, унаочнених через художнє посередництво цього образу. Уперше здійснено типологію рис образу мілітарного героя в поетичному доробку «Празької школи» на основі концепції Ю. Шевельова про новий тип людини у повоєнній літературі. Вияв образу простежено крізь призму концепції «пасивного страждання» В. Б. Єйтса, що характеризує літературну критику поезії міжвоєнного періоду. Доведено, що найчастотнішою рисою образу мілітарного героя є риса войовника, через яку трансльовано проблематику героїзації бою й апологетизації війни. Вона може бути поєднана з рисами аристократа й державника, де аристократизм тяжіє до ознак лицарства і є дотичним до проблем національної пам’яті та історичного досвіду. Аналіз творів засвідчує, що мілітарний герой органічно виростає на тлі особистого досвіду «пражан». Через нього постульовано життєствердний пафос війни, а також прийняття страждань і смерті. Отже, таке втілення докорінно суперечить єйтівській концепції «пасивного страждання», на якій постає антивоєнна за своєю суттю європейська лірика міжвоєнного періоду.
Influencia de las redes sociales en la vida académica de estudiantes de mercadotecnia en una universidad mexicana
Authors: López Bojórquez Brenda Josseline , Juárez Solis Sandra , Zetina Pérez Carlos David
Published: March 2023

El objetivo es analizar la influencia de las redes sociales en los estudiantes de la licenciatura de mercadotecnia en una Universidad Pública del Estado de Tabasco, logrando identificar los factores que influyen en su vida académica. La investigación es de enfoque cuantitativo, con un alcance descriptivo, y un diseño no experimental; la unidad de análisis fue de 2018 alumnos activos, mediante una encuesta en la plataforma de Google Forms, con el fin de saber la frecuencia que le dan ellos al uso de las redes sociales y si es utilizada durante sus horarios de clases. Los resultados mencionan que las redes sociales si tienen impacto en su vida escolar y que las horas que pasan navegando en las redes sociales influyen en su vida académica. Se concluye que las redes sociales tienen un impacto negativo en los alumnos, mostrando una dependencia con las mismas que afecta a su rendimiento escolar.
Tendencias, amenazas, discursos y prácticas
Authors: Uribe Cáceres Sergio
Published: March 2023

En el desarrollo de la siguiente ponencia, presentada durante el V Seminario Internacional Virtual “La Seguridad Marítima de los Espacios Oceánicos, frente a la Amenaza del Crimen Organizado Transnacional”, se examinaron los efectos de la globalización que imponen una serie de retos y desafíos a la comunidad internacional, en el propósito de ilustrar sobre la forma de contrarrestar las principales amenazas que se presentan en el contexto marítimo.En una convergencia de intereses criminales, organizaciones de todo tipo y calaña colaboran entre sí para multiplicar su capacidad delincuencial. Grupos terroristas cooperan con carteles de la droga y organizaciones de tráfico ilícito se confabulan con narcoguerrillas. La interdependencia y capacidad de adaptación de las organizaciones de crimen transnacional afectan a todos y cada uno de los países en un mundo marítimo globalizado, obligando a que la respuesta deba ser más articulada y enfocada en la búsqueda de propósitos e intereses comunes.
El plástico como una amenaza al presente y futuro de la vida en la tierra
Authors: Gómez Astaiza Érika Andrea , González Calderon Nicolás Mateo , Simmonds Manrique María Paula
Published: March 2023

En el presente ensayo, se tomará como tema principal la amenaza que ha representado la sobreproducción de plástico para la existencia de los seres vivos en la Tierra y, sobre todo, cómo este material está atentando contra la vida en los océanos. Desde hace más de 60 años, hubo un “boom” en la elaboración del plástico, lo cual dejo como consecuencia miles de toneladas de desechos que fueron arrojados al océano y que han contaminado gravemente el ecosistema marino, acabando con la vida de millones de animales que, en varias ocasiones, han confundido bolsas plásticas con alimentos o, incluso, se han visto atrapados por residuos plásticos que se han convertido en trampas mortales para los animales. Muchas empresas productoras de plástico se han convertido en los principales contaminantes y, a pesar de esto, no han establecido propuestas lo suficientemente sólidas para contrarrestar el impacto que han tenido sus productos en el medio ambiente.
Viviendas palafíticas en el borde costero del Pacífico colombiano: análisis alrededor de los intereses marítimos nacionales
Authors: Buitrago Puerta Sergio Antonio , Burgos López Laura , González Marín Lucía
Published: March 2023

Los palafitos, como alternativa para contrarrestar los efectos del cambio mareal en el litoral PACIFICO colombiano, se han convertido en una situación de gran recurrencia en el país que involucra la injerencia directa de muchos aspectos de la administración estatal. Dada la magnitud de este fenómeno y con miras a realizar un análisis de las diferentes perspectivas con respecto a los Intereses Marítimos Nacionales, que obedecen a la hoja de ruta del Estado colombiano frente al desarrollo de las zonas marinas y costeras del territorio, se realiza la descripción de la situación palafítica en la franja costera del Pacífico colombiano en torno a los aspectos normativos, de gestión del riesgo, ambientales, económicos y socioculturales. El artículo concluye que podría existir una lucha por la definición de sentido entre las visiones de desarrollo marítimo que están enmarcadas en los IMN promovidos por el Estado colombiano y aquellas visiones sobre lo que las poblaciones locales consideran deseable, más allá de que sea considerado o no desarrollo.
La acción integral del Estado para el fortalecimiento del poder marítimo colombiano
Authors: Rios Moncaya Christian Alfonso , Uribe Cáceres Sergio
Published: March 2023

De los grandes retos en el mundo contemporáneo para afrontar las nuevas modalidades de conflictos que se presentan en cualquier región del mundo. es poder establecer una acción integral que proyecte el poder militar respaldado y soportado por la voluntad política, el sector privado -en lo económico- y la población civil. Con estos componentes se propone una acción conjunta, cooperativa y contundente para afrontar los grandes desafíos del siglo XXI con respecto a la seguridad y defensa de las naciones. Las talasocracias ponen de manifiesto entonces la necesidad de fortalecer y proyectar el poder marítimo tanto geopolítica como oceanopoliticamente, referido a la conformación de un liderazgo estatal fuerte para sobrevivir dentro de un sistema internacional de naturaleza anárquica; esta razón conlleva a orientar los intereses nacionales a la supervivencia misma del Estado. En Colombia, por su parte, para fortificar su poder marítimo, el liderazgo regional y la supervivencia misma de la nación, se hace necesario que incorpore la acción integral dentro de sus procesos multidimensionales de la estrategia e involucrarlos a sus propios intereses nacionales como eje central en los niveles tácticos y operacionales, para la conformación de una acción conjunta con los demás sectores de la sociedad diferentes a lo castrense.
Marco normativo de la implementación del Convenio de Lima en Colombia
Authors: Cury Alarcón Ivana Paola , Mancera Cortés Juliana , Gónzalez Arévalo Sonia Carolina
Published: March 2023

Los océanos se encuentran en una situación crítica, dónde más del 40% de su extensión se encuentra afectada y se estima que el 66% sufre efectos acumulados, causados por variantes como la contaminación. Es así que Colombia trabaja alrededor de estos asuntos, teniendo en cuenta lo acordado en instrumentos de orden internacional, como es el caso del Convenio para la Protección del Medio Marino y la Zona del Pacífico Sudeste (Convenio de Lima), el cual corresponde a un marco de cooperación para el control y vigilancia sobre la contaminación marina, es decir los tipos y fuentes de contaminación, por medio de la reducción de aspectos como la descarga de sustancias tóxicas, perjudiciales y nocivas. Igualmente, en el marco nacional, Colombia cuenta con diferentes herramientas las cuales han permitido contextualizar y llevar a cabo los compromisos internacionales del país y en concordancia con nuestras políticas públicas. De esta manera, el presente escrito tiene como propósito describir el marco de acción que Colombia ha acogido para la región Pacífico en contaminación marina, después de la ratificación del Convenio de Lima, por medio de la Ley 45 de 1985, la cual entró en vigor en mayo del año 1986.
Desarrollo de la industria naval en Colombia: una mirada desde la complementariedad entre sectores
Authors: Coronado Rincón Oscar Mauricio
Published: March 2023

El desarrollo de la industria naval es uno de los intereses marítimos de Colombia debido a su importancia en términos de la defensa del territorio y el desarrollo económico. Esta industria tiene un efecto que apalanca la economía. capaz de ser un motor generador de empleo en diferentes ramas de actividad económica. En este artículo se revisan los vínculos de la industria naval con otros sectores y se proponen recomendaciones para su desarrollo en el país contribuyendo a la visión de Colombia como Potencia Media Oceánica.
Cambios y desafíos navales en un ambiente y escenario de seguridad marítima global
Authors: Camacho Torres Jenny Alexandra , Urrego Niño Diana Consuelo , Parada Pérez Christian Enrique
Published: March 2023

En el presente documento se da a conocer cómo afectan los nuevos retos y amenazas, propias del mundo actual que afectan la seguridad en el escenario marítimo a nivel global. Se señala que al analizar escenarios en el entorno global, es posible entender los múltiples riesgos y amenazas trasnacionales que emergen, en especial aquellas que utilizan el medio marino para desarrollarse. Se destacan algunos organismos internacionales que mantienen una permanente búsqueda de medidas para contrarrestarlas. De igual forma a nivel nacional se consideran documentos rectores que determinan el derrotero para la proyección de la “Estrategia Marítima para una Colombia Azul” y cómo la Armada Nacional dirige sus esfuerzos en la protección de los intereses marítimos de la Nación.
El poder naval y los intereses marítimos: binomio para el desarrollo y la seguridad
Authors: Díaz Delgado José , Valdivia Correa Renzo
Published: March 2023

En este artículo veremos cómo en el Perú desde varias décadas atrás, dentro su visión de país marítimo, se viene fortaleciendo la doctrina, conocimiento e interés sobre el dominio marítimo a fin de impulsar el desarrollo de sus Intereses Marítimos y su Poder Naval, generado por un conocimiento en las diferentes dimensiones del mismo. En este sentido iremos esbozando diferentes puntos de vista respecto a la conceptualización de los Intereses Marítimos, el Poder Naval y la importancia de la conciencia marítima en el impulso hacia el logro de los mismos, que coadyuvan al desarrollo y seguridad de los objetivos nacionales.
La proyección geopolítica bioceánica del Perú y sus intereses marítimos
Authors: Valdivia Correa Renzo Antonio
Published: March 2023

La condición marítima del Perú, propia de la posición estratégica en la región, le brinda un gran potencial por el acceso a dos grandes cuencas y proyección al Océano Atlántico, pero también supone desafíos para el Estado, debido a las dimensiones geográfcas del país lo cual es común para todas las naciones de la región, por lo que resulta necesario el establecimiento de herramientas que promuevan la interconexión entre ellas, aprovechando las redes ﬂuviales y viales, pero también requiere una reorganización interna mediante ejes de desarrollo geoeconómicos que sean congruentes con los ejes de integración regionales, considerando que las redes ﬂuviales navegables sean parte integrante de los océanos y/o prolongación de los mismos. Los intereses marítimos nacionales estarán orientados al desarrollo económico e industrial y al bienestar de la nación, y de esta forma contribuir al fomento de la identidad nacional y optimizar de manera sostenible el uso de espacios marítimos, para lo cual se reuqiere de un adecuado sistema de seguridad y defensa nacional.
Seguridad integral marítima como base para el desarrollo económico
Authors: Hurtado Valdivieso Rafael
Published: March 2023

Colombia depende del transporte marítimo para incrementar su participación en los mercados internacionales y consolidar su desarrollo económico; la seguridad en las áreas marítimas jurisdiccionales ha sido defnida a nivel país, bajo el concepto de Seguridad Marítima Integral establecido por la Dirección General Marítima, sin embargo, dado el carácter estratégico del transporte marítimo y lo dispuesto en las leyes colombianas, este propósito está ligado al trabajo de la Armada Nacional de Colombia y en especial a su Cuerpo de Guardacostas. Por lo anterior, mantener unas líneas de comunicación marítimas seguras y efcientes debe ser considerado un objetivo de importancia nacional que impactará el desarrollo económico del país.
More on the Origin of Refuge
Authors: Hanson Kristin
Published: March 2023

editorial
Basic survival manual for descriptive statistical analysis [Manual de supervivencia básico para los análisis estadísticos descriptivos]

Authors: Ibáñez-López Francisco  Javier , Ponce Gea Ana Isabel , Pedreño-Plana Marina , Sánchez-Martín Micaela
Published: March 2023

El análisis estadístico descriptivo es el primer paso que cualquier persona que pretenda realizar una investigación cuantitativa debe dar cuando se dispone a realizar el análisis de los datos recogidos durante el trabajo de campo de su investigación. Es fundamental conocer de una forma descriptiva las características de la población participante en el estudio y los resultados iniciales obtenidos, como paso previo a la realización de análisis inferenciales o al ajuste de modelos estadísticos que expliquen de forma más profunda los datos obtenidos. Este trabajo presenta una introducción a las diferentes variables que nos podemos encontrar y a la implementación de su análisis descriptivo mediante el software estadístico libre jamovi. Se muestra, por tanto, una herramienta sin coste alguno que ofrece resultados potentes sin necesidad de conocer un lenguaje de programación estadístico.
Stereoselective Two-Carbon Ring Expansion of Allylic Amines via Electronic Control of Palladium-Promoted Equilibria
Authors: Knowles Jonathan , Mikan Charles , Matthews Aidan , Harris Daniel , McIvor Charlotte , Waddell Paul
Published: March 2023

Despite their potential value within drug discovery, general methodologies enabling the two-carbon homologation of pyrrolidine and piperidine systems have yet to be developed. Herein we report that palladium-catalysed allylic amine rearrangements enable efficient two-carbon ring expansion of 2-vinyl pyrrolidine and piperidines to their azepane and azocane counterparts. Conditions are mild, tolerant of a range of functional groups and the process can occur with a high degree of enantio-retention. The products formed undergo a range of orthogonal transformations, making them ideal scaffolds for the creation of compound libraries.
Multi-stimuli-Responsive and Cell Membrane Camouflaged AIE Nanogels for Precise Chemo-Photothermal Synergistic Therapy of Tumors
Authors: Zhang Liping , Tang Ben Zhong , Zhao Zheng , Xiong Yu , Wang Zaiyu , Zhang Rongyuan , Yang Han , Wang Wenjin , Zhao Yun , He Wei , Qiu Zijie , Wang Dong
Published: March 2023

Targeted and controllable drug release at lesion sites with the aid of visual navigation in real-time is of great significance for precise theranostics of cancers. Benefiting from the marvellous features (e.g. bright emission and phototheranostic effect in aggregates) of aggregation-induced emission (AIE) materials, constructing AIE-based multifunctional nanocarriers that act as all-rounders to integrate multimodalities for precise theranostics is highly desirable. Here, an intelligent nanoplatform (P-TN-Dox@CM) with homologous targeting, controllable drug release, and in vivo dual-modal imaging for precise chemo-photothermal synergistic therapy is proposed. AIE photothermic agent (TN) and anticancer drug (Dox) are encapsulated in thermo-/pH-responsive nanogels (PNA), and the tumor cell membranes are camouflaged onto the surface of nanogels. Active targeting can be realized through homologous effects derived from source tumor cell membranes, which significantly elevates the specific drug delivery to tumor sites. After being engulfed into tumor cells, the nanogels exhibit a burst drug release at low pH. The near-infrared (NIR)-photoinduced local hyperthermia can activate severe cytotoxicity and further accelerate drug release, thus generating enhanced synergistic chemo-photothermal therapy to thoroughly eradicate tumors. Moreover, P-TN-Dox@CM nanogels could achieve NIR-fluorescence/photothermal dual-modal imaging to monitor dynamic distribution of therapeutics in real-time. This work highlights the great potential of smart P-TN-Dox@CM nanogels as a versatile nanoplatform to integrate multimodalities for precise chemo-photothermal synergistic therapy in combating cancers.
International Conference on Pure and Applied Physics
Authors: Nancy Dr. A. Christina
Published: March 2023

This conference aims to bring together experts in academia and industry from India and abroad to share their ideas and research findings in thrust areas of Pure & Applied Physics. Young scientists, students and faculty will have the opportunity to interact with their peers, assimilate knowledge on current developments in physics-related fields, and present their recent innovative research through oral and poster presentations.
Evaluation of Surface Water Quality Indices in Mthatha River Using Multivariate Statistical Techniques
Authors: Nombuyiselo Makupula , Taiwo Amoo Oseni , Abdultaofeek Abayomi , Ikudayisi Akinola
Published: March 2023

Mthatha town of Eastern Cape Province, South Africa has been challenged to address the pollutant issues that are coming from rampant densification and effluent concentration discharge from the Mthatha Correctional Services Centre and the Efata School for the Blind and Deaf which have caused ineffable impaired damage to the Mthatha River Catchment (MRC). This paper is aimed at identifying drivers of poor water quality in the catchment and classified the River’s water quality into different cluster groups for proper pollutant source control measures. Water quality parameters data comprising of pH; conductivity; Phosphorus; Ammonia (NH4-N); Feacals; and E-coli covering 95 percent and 105 percent of the upstream and downstream sections of the River were available at ten monitored sites of the river catchment. These datasets covering eight years 2012-2020 were analysed in this study. Factor analysis as a choice of principal component analysis (PCA) and Agglomerative Hierarchical Clustering (AHC) was used to deduce inferences for the pollutants’ subsequent classification. The results classified the catchment into three different clusters of lower pollutant (LP), medium pollutant (MP), and high pollutant (HP) areas, with PC1 accounting for 84.54% of the total variance from the three components classification. Adaptive catchment managers would find usefulness in the employed statistical tools in ensuring real-time measures for river non-point pollutants sources control that could offer additional benefits in maintaining a safe life above and below water in the preservation of their public values benefit. The study recommends the issuance of compliance notices and non-point pollutant source control measures to improve the water quality (WQ) parameters.
Tofu Wastewater (TWW) Treatment and Hydrogen (H2) Production by Using A Microbial Electrolysis Cell (MEC) System
Authors: Satar Ibdal , Sirajuddin Muhammad Mar’ie , Permadi Adi , Latifatunnajib Sukma
Published: March 2023

High organic pollutant in tofu wastewater (TWW) raises a negative impact on environmental sustainability and health. Therefore, the TWW must be treated before it is discharged into the environment. Microbial electrolysis cell (MEC) is one of the green technologies that can be used to treat wastewater and generate hydrogen as well. This work tries to investigate the performance of MEC based on the decrement of organic pollutants in TWW. Some important parameters of organic pollutants in TWW such as chemical oxygen demand (COD), biological oxygen demand (BOD), total suspended solids (TSS), total dissolved solids (TDS), total solid (TS), and pH were evaluated before and after MEC operation. The results showed that the COD and BOD levels decreased around 56% and 35% while pH increased from 7.90 to 7.16. Additionally, the TSS, TDS, and TS decreased by around 35.0%, 45.5%, and 33.2%. In addition, the optimum hydrogen yield (YH2) and hydrogen production rate (QH2) were obtained at 114 ± 0.1 mL H2/g COD 360 ± 20 mL H2/L/d. Overall, the MEC system could be used to reduce the level of organic pollutants in TWW and generated H2 at the same time.
Tecnoestrés y trabajo remoto: aportes multidisciplinarios
Authors: Vivas-Manrique Samuel David , Alarcón Carolina Duarte , Ochoa Muñoz Andrés Felipe , Ordóñez-Hernández Cecilia Andrea , Leal-Márquez Diana , Villota Castillo Adriana Marcela , Rojas Peña Oscar Mauricio , Martínez Álvarez Luz América , López Laverde Jessica
Published: March 2023

La pandemia generada por el Sars-Cov II, Covid-19, ha impulsado el uso de las tecnologías de la información y la comunicación en los contextos laborales. Permitió la continuidad del servicio a muchas empresas y trabajadores en medio de las restricciones y confinamientos que los países adoptaron como medida sanitaria. De este modo, se fortaleció la modalidad de trabajo remoto que ha llegado para quedarse. No obstante, pese a las grandes oportunidades y virtudes de estas tecnologías, también existen riesgos para la salud de los trabajadores. Uno de ellos es el tecnoestrés, que cada vez más se convierte en una amenaza para la salud pública. Una mirada interdisciplinaria a los riesgos ocupacionales del trabajo remoto permite que los empleadores, trabajadores, profesionales inmersos en la seguridad y salud ocupacional puedan establecer medidas de prevención y protección en aras de salvaguardar el bien más preciado de todo ser humano, su salud. Al respecto, una investigación presenta un modelo biopsicosocial del tecnoestrés y su incidencia en el profesorado universitario. Población sobre la cual una segunda investigación indaga respecto de las condiciones laborales que la pandemia les ha impuesto y que una tercera investigación, fortalece con los aportes de la ergonomía en el trabajo remoto. Tecnoestrés y trabajo remoto, una mirada interdisciplinaria, es un tema urgente, emergente e ineludible ante los nuevos desafíos y retos que se presentan con la inmersión de las tecnologías de la información y la comunicación en el mundo del trabajo.Libro completo