bluuebunny/crossref_metadata_2025 huggingface dataset:
Networked Time-series Prediction with Incomplete Data via Generative Adversarial Network
Authors: Zhu Yichen , Jiang Bo , Jin Haiming , Zhang Mengtian , Gao Feng , Huang Jianqiang , Lin Tao , Wang Xinbing
Published: February 2024

A
networked time series (NETS)
is a family of time series on a given graph, one for each node. It has a wide range of applications from intelligent transportation to environment monitoring to smart grid management. An important task in such applications is to predict the future values of a NETS based on its historical values and the underlying graph. Most existing methods require complete data for training. However, in real-world scenarios, it is not uncommon to have missing data due to sensor malfunction, incomplete sensing coverage, and so on. In this article, we study the problem of
NETS prediction with incomplete data
. We propose networked time series Imputation Generative Adversarial Network (NETS-ImpGAN), a novel deep learning framework that can be trained on incomplete data with missing values in both history and future. Furthermore, we propose
Graph Temporal Attention Networks
, which incorporate the attention mechanism to capture both inter-time series and temporal correlations. We conduct extensive experiments on four real-world datasets under different missing patterns and missing rates. The experimental results show that NETS-ImpGAN outperforms existing methods, reducing the Mean Absolute Error by up to 25%.
Contextualization, Authenticity, and the Problem Description Effect
Authors: Lovellette Ellie , Bouvier Dennis J , Matta John
Published: February 2024

In recent years, computing education researchers have investigated the impact of problem context on students’ learning and programming performance. This work continues the investigation motivated, in part, by cognitive load theory and educational research in computer science and other disciplines. The results of this study could help inform computing assessment design. If the context and authenticity of a programming problem aid student performance then, instructors’ time in creating appropriately contextualized programming problem descriptions is time well-spent. On the other hand, if the context of a programming problem hinders performance, then instructors should leave it out of programming problems.

Recent studies investigating the impact of programming problem context on student success have arrived at different conclusions.

Presented here is a series of experiments, conducted over 3 years, investigating the impact of context on novice programmers’ success in algorithmic programming assignments using three contextualized tasks and their generic counterparts. This experiment series also looked into the possibility of “authenticity” as a factor affecting performance. Common sense would suggest that a student would perform better on a problem if they understood or cared about it. Contextualization could provide authenticity and authenticity could provide interest. Research suggests that perceiving a problem as authentic has a positive effect on engagement and learning. Alternatively, if a problem is “just an abstract set of numbers”, it may be harder to make sense of the details and the lack of context could consequently contribute additional cognitive load to an already challenging assignment.

The results of this study show that assignment context and problem context authenticity have no effect on the performance of novice programmers. We think, however, that contextualization could be worth investing in to support students’ interest in computing. Additional implications of the results suggest that instructors can assign equivalent versions of the same problem in varied contexts to suit their students’ interests without worrying if the context will hinder performance.
Are Victims Virtuous or Vilified? The Stories We Tell Ourselves (and Each Other)
Authors: Rawlings Craig M. , Cook Edgar V. , Hasenour Kiersten , Maloney E.K. , Smith-Lovin Lynn
Published: February 2024

Derogation of the victim refers to the tendency of an observer to negatively evaluate someone hurt by the action of another. Victim derogation has been a core feature of social psychology for decades, but evidence suggests this phenomenon is weakening. It may even be reversing into a valorization of victims. Is this empirical pattern due to methodological changes and shifts in theoretical framing of victim studies, or have there been large-scale cultural changes in how we view victims? This review outlines the theoretical and methodological origins of the derogation effect. It then discusses contemporary research streams that show the malleability of victim perception in research that considers the entire harmful social interaction. These studies suggest that shifts in broader social, political, and cultural environments may have impacted the social psychological foundations of derogation.
Modeling and Simulation Characteristics of a Highly-Sensitive Stack-Engineered Junctionless Accumulation Nanowire FET for PH3 Gas Detector
Authors: Neeraj  , Sharma Shobha , Goel Anubha , Sonam Rewari , Deswal S. S. , Gupta R. S.
Published: February 2024

In this manuscript, a Stack Engineered Junctionless Accumulation Nanowire FET (SE-JAM-NW FET) has been proposed for low - power and high sensitivity phosphine (PH3) gas detection applications. In comparison to a standard nanowire FET, the SE-JAM-NW FET is used at nanoscale dimensions because of its inherent benefits, including low cost, improved portability, low Off- state current and increased On-state current with low - power consumption. To implement the SE-JAM-NW FET as a phosphine gas sensor, four catalytic metals, Platinum (Pt), Rhodium (Rh), Iridium (Ir) & Palladium (Pd) have been employed as gate electrodes. For designing gas sensor, various electric parameters like potential, electron concentration, recombination rate and electron velocity are evaluated for PH3 gas detection. To forecast the sensor’s response, analog characteristics like changes in drain current, transconductance & output conductance are being simulated for different catalytic metal work functions (200 meV, 150 meV, 100 meV and 50 meV) at the gate electrode. The variation in On-state current-to-Off-state current ratio (IOn/IOff), On-state current (IOn) & subthreshold leakage current (IOff) for sensing the gas molecules has been used to quantify the sensitivity. The effects of silicon pillar-based radius variation and channel length variation on the sensitivity-based parameters are also investigated. Each catalytic metal exhibits improved sensitivity with increased channel length and decreased radius. The outcomes of the ATLAS 3-D device simulator’s numerical simulation closely match with those of the derived analytical model.
Bacteremia and Mortality among Patients with Nontunneled and Tunneled Catheters for Hemodialysis
Authors: Lima Carla Santos De , Vaz Flora Braga , Campos Rodrigo Peixoto
Published: February 2024

Introduction. Central venous catheters for hemodialysis (HD) can be nontunneled catheters (NTC) or tunneled catheters (TC). Bacteremia and dysfunction are complications that can impact morbidity and mortality. We decided to compare the rates of bacteremia and dysfunction between NTC and TC and patient survival 90 days after catheter insertion. Methods. Retrospective cohort to evaluate catheters inserted between January 2011 and December 2020 in a tertiary hospital. Catheters in patients with end-stage chronic kidney disease were included. Patients with acute kidney injury, catheters that lasted less than three HD sessions, and patients who died within one week after insertion were excluded. Bacteremia and dysfunction rates, bacteremia-free survival, and dysfunction-free survival were investigated. Multivariable analysis was performed using a Cox proportional hazards regression model for patient survival at 90 days. Results. 670 catheters were analyzed in 287 patients, 422 NTC (63%), and 248 TC (37%). The rates of confirmed bacteremia per 1,000 catheter-days were 1.19 for NTC and 0.20 for TC (p<0.0001). The confirmed or possible bacteremia rates were 2.27 and 0.37 per 1,000 catheter-days for NTC and TC, respectively (p<0.0001). The dysfunction rates were 3.96 and 0.86 for NTC and TC, respectively (p<0.0001). Patient survival at 90 days was higher in the TC group than the NTC group (96.8% vs. 89.1%; p<0.0001). Conclusion. We found lower rates of bacteremia and dysfunction for TC and demonstrated that using NTC affects patient mortality.
Current Strategies for Tracheal Decellularization: A Systematic Review
Authors: Jiwangga Dhihintia , Mahyudin Ferdiansyah , Mastutik Gondo , Juliana  , Meitavany Estya Nadya
Published: February 2024

The process of decellularization is crucial for producing a substitute for the absent tracheal segment, and the choice of agents and methods significantly influences the outcomes. This paper aims to systematically review the efficacy of diverse tracheal decellularization agents and methods using the PRISMA flowchart. Inclusion criteria encompassed experimental studies published between 2018 and 2023, written in English, and detailing outcomes related to histopathological anatomy, DNA quantification, ECM evaluation, and biomechanical characteristics. Exclusion criteria involved studies related to 3D printing, biomaterials, and partial decellularization. A comprehensive search on PubMed, NCBI, and ScienceDirect yielded 17 relevant literatures. The integration of various agents and methods has proven effective in the process of tracheal decellularization, highlighting the distinct advantages and drawbacks associated with each agent and method.
Application of Common Components Analysis to Mid-Infrared Spectra for the Authentication of Lebanese Honey
Authors: El Hajj Rita , Skaff Wadih , Estephan Nathalie
Published: February 2024

Honey is considered as a premium food produced by honeybees. It is highly appreciated by consumers around the world and raises a major concern nowadays which is ensuring its authenticity in respect to its production and its botanical origin. In Lebanon, honey is mainly multifloral which makes its authentication rather difficult. While mid-infrared (MIR) spectroscopy combined with multivariate analysis has proven to be successful in authenticating unifloral honey, the challenge with Lebanese honey lies in assessing its performance with multifloral honey. Therefore, this work aims to test the performance of common components analysis (CCA) applied on mid-infrared spectra in the authentication of multifloral Lebanese honey. For this purpose, 96 multifloral Lebanese honey samples of different floral sources were collected from different regions of the Lebanese territory and analyzed using MIR spectroscopy. CCA applied to the spectral data, allowed a separation between honeydew honey samples and floral honey samples. In addition, honey samples collected from the Bekaa plain region were differentiated from the other honey samples collected from all the other Lebanese geographical regions. This discrimination between the groups of honey samples is based essentially on their sugar composition.
The Peak Stability Analysis through Hysteresis Phenomenon on Heterogeneous Networks
Authors: Yao Shunyu , Lu Weike , Liu Lan , Hu Guojing
Published: February 2024

The macroscopic fundamental diagram (MFD) is a nonuniversal changing process over network traffic status which indicates different shapes in different networks. Hysteresis is observed in the MFD of some urban networks. It is a unique phenomenon when the network remains at low stability level and usually appears around the congestion period. This paper analyzed network peak stability through focusing on hysteresis. The formation mechanism of hysteresis is deduced from the mathematical method based on previous research studies. The precondition of hysteresis and the changing process of network state can be figured by mathematical deduction. It indicates that hysteresis only occurs conditionally in the period of macroscopic congestion and is not a universal phenomenon. Heterogeneity is an important factor leading to network instability. The hysteresis patterns of different peaks in MFD are different due to the variation of network flow. Real data are collected from Atlanta’s urban network to verify the analysis of hysteresis. To discuss the changing process of hysteresis in different peaks, a three‐stage division is proposed and time series is presented as a third dimension in MFD. It is worth noticing that the existence and form of hysteresis in morning and evening peaks are different. Although there is a higher peak flow in the morning peak, the stability of the evening peak performs better when hysteresis occurs in the network. The different fluctuations in the morning and evening peaks are exhibited through the 3D version of MFD. The otherness of hysteresis in different peaks is explained through a 3D coordinate system with cross‐compared corresponding indexes.
Cutaneous Neuroendocrine Metastases of Visceral Origin Responsive to Surgical Resection and Targeted Radionuclide Therapy
Authors: Tung-Hahn Eleanor , El-Haddad Ghassan , Strosberg Jonathan
Published: February 2024

Neuroendocrine neoplasms (NENs) encompass a diverse range of biologically and behaviorally distinct epithelial malignancies that derive from neuroendocrine cells. These neoplasms are able to secrete a variety of bioactive amines or peptide hormones. The majority of NENs are well-differentiated and are defined as neuroendocrine tumors (NETs). While NETs are known to frequently metastasize to lymph nodes, liver, and lungs, spread to the skin is extremely rare and is often a late finding. Because cutaneous metastasis from a visceral site represents distant tumor dissemination, prompt histologic diagnosis is critical in terms of selecting further treatment options and ultimately impacts subsequent prognosis. This report presents a man with painful cutaneous NET metastases initially on the face then scalp. He had a prior history of longstanding and progressive stage IV visceral disease. Multimodal therapy with initial surgical resection of the larger facial lesion and radionuclide infusion therapy was undertaken. Excision fully removed the temple lesion and resolved pain. Peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE, a radiolabeled somatostatin analog that targets somatostatin receptors on NETs, was given along with maintenance lanreotide therapy, which resolved the scalp lesion, prevented recurrence of prior lesions and development of new cutaneous metastases, and controlled his visceral disease. PRRT has not been previously described in the management of cutaneous NET metastases. Due to the rare nature of cutaneous NET metastases, there is no consensus regarding optimal management. As such, we propose novel multimodal therapy involving excision and targeted radionuclide therapy as a possible effective option.
Modeling the Peak‐Period Bus Commuting Behavior with Staggered Work Hours Using a Regret‐Minimizing Learning Method
Authors: Qiang Shengjie , Huang Qingxia
Published: February 2024

The staggered work hours (SWH) policy is a practical strategy for managing travel demand, aiming to spread out the temporal distribution of travel volume by adjusting the schedules of travelers’ activities. The influence of the SWH policy on the commuting patterns of passengers using bus transit is not yet clear. We addressed this issue in a many‐to‐one bus line, treating commuters as Q‐learning agents learning to minimize regrets by selecting appropriate bus runs. The learning outcomes reveal a SWH‐induced equilibrium, where commuters departing from the same station with the same work start time experience identical minimal commuting costs, regardless of the chosen bus. Subsequently, we investigate the effectiveness of SWH policy by manipulating two key control variables: the division of travel demand between two categories of travelers and the staggered time interval. The results confirm that congestion during peak hours can potentially be mitigated by carefully selecting the above two key parameters. Correspondingly, we provide optimal control boundaries for these two parameters to design an effective SWH policy. Furthermore, we explore the combined impact of physical distancing and SWH policy on traffic flow patterns during an epidemic outbreak. Concurrently, we assess the infection risk through a surrogate index, revealing that the SWH policy has a positive effect in mitigating the risk of contact exposure.
Supplementary Table S2 from Unsatisfactory Fecal Immunochemical Tests for Colorectal Cancer Screening: Prevalence, Reasons, and Subsequent Testing
Authors: Liu Po-Hong , Nair Rasmi G. , Skinner Celette Sugg , Murphy Caitlin C. , Kim Eric J. , Ortiz Cynthia , Wang Lei , Hu Ellen , Lykken Jacquelyn M. , Levin Theodore R. , Green Beverly B. , Hahn Erin E. , Santini Noel , Halm Ethan A.
Published: February 2024

This table presents predictors of unsatisfactory FIT, stratified by type of test
Supplementary Figure S1 from Genetic and Environmental Causes of Variation in an Automated Breast Cancer Risk Factor Based on Mammographic Textures
Authors: Ye Zhoufeng , Dite Gillian S. , Nguyen Tuong L. , MacInnis Robert J. , Schmidt Daniel F. , Makalic Enes , Al-Qershi Osamah M. , Nguyen-Dumont Tu , Goudey Benjamin , Stone Jennifer , Dowty James G. , Giles Graham G. , Southey Melissa C. , Hopper John L. , Li Shuai
Published: February 2024

Supplementary Figure S1 shows that the best-fit piecewise linear model was found when the turning point was selected at the age of 46; the AIC was 2.00-8.81 units smaller than the AICs of the models when the turning point was selected at other ages. It also shows that the best-fit piecewise linear model was found when the turning point was selected at the age of 65; the AIC was 1.55-5.58 units smaller than the AICs of the models when the turning point was selected at other ages.
Table S2 from Metabolic Syndrome and the Risk of Ductal Carcinoma In Situ of the Breast in the UK Biobank
Authors: Peila Rita , Rohan Thomas E.
Published: February 2024

Table S2 shows the association of metabolic syndrome with risk of DCIS of the breast in the UK Biobank including only women with ≥2 years of follow-up
Table S1 from Metabolic Syndrome and the Risk of Ductal Carcinoma In Situ of the Breast in the UK Biobank
Authors: Peila Rita , Rohan Thomas E.
Published: February 2024

Table S1 shows the characteristics of the study population by menopausal and metabolic syndrome status.
Supplementary Table 1 from Patterns of Anticoagulation Use and All-Cause of Mortality in Cancer Patients with Atrial Fibrillation
Authors: Han Xu , Yang Xiaolei , Hidru Tesfaldet H. , Wang Chengfang , Xia Yunlong
Published: February 2024

Supplementary Table 1 describes the cross-sectional patterns of anticoagulation use among different cancer patients with AF.
Supplementary Figure S4 from Genetic Factors and Long-term Treatment-Related Neurocognitive Deficits, Anxiety, and Depression in Childhood Leukemia Survivors: An Exome-Wide Association Study
Authors: Petrykey Kateryna , Lippé Sarah , Sultan Serge , Robaey Philippe , Drouin Simon , Affret-Bertout Laurence , Beaulieu Patrick , St-Onge Pascal , Baedke Jessica L. , Yasui Yutaka , Hudson Melissa M. , Laverdière Caroline , Sinnett Daniel , Krajinovic Maja
Published: February 2024

Combined effect model of the APOL2 and C6orf165 genes
Supplementary Figure S1 from Genetic Factors and Long-term Treatment-Related Neurocognitive Deficits, Anxiety, and Depression in Childhood Leukemia Survivors: An Exome-Wide Association Study
Authors: Petrykey Kateryna , Lippé Sarah , Sultan Serge , Robaey Philippe , Drouin Simon , Affret-Bertout Laurence , Beaulieu Patrick , St-Onge Pascal , Baedke Jessica L. , Yasui Yutaka , Hudson Melissa M. , Laverdière Caroline , Sinnett Daniel , Krajinovic Maja
Published: February 2024

Manhattan plot for the Trail making test
Supplementary Figure S3 from Community-Level Factors Associated with Hepatocellular Carcinoma Incidence and Mortality: An Observational Registry Study
Authors: Mezzacappa Catherine , Rossi Raiza , Jaffe Ariel , Taddei Tamar H. , Strazzabosco Mario
Published: February 2024

Supplementary Figure S3: Correlation between average annual cases of HCC (y-axis) and proportion Hispanic ethnicity (x-axis).
Supplementary Figure S13 from Community-Level Factors Associated with Hepatocellular Carcinoma Incidence and Mortality: An Observational Registry Study
Authors: Mezzacappa Catherine , Rossi Raiza , Jaffe Ariel , Taddei Tamar H. , Strazzabosco Mario
Published: February 2024

Supplementary Figure S13: Correlation between average annual cases of HCC (y-axis) and proportion of adults with diabetes (x-axis).
Supplementary Table S1 from Decline in the Incidence of Distant Recurrence of Breast Cancer: A Population-Based Health Record Linkage Study, Australia 2001–2016
Authors: Lord Sarah J. , Daniels Benjamin , O'Connell Dianne L. , Kiely Belinda E. , Beith Jane , Smith Andrea L. , Pearson Sallie-Anne , Chiew Kim-Lin , Bulsara Max K. , Houssami Nehmat
Published: February 2024

Supplementary Table S1: Data sources and criteria for classifying distant recurrence from administrative health records.
Supplementary Table S1 from The Influence of Smoking and Occupational Risk Factors on DNA Methylation in the AHRR and F2RL3 Genes
Authors: Pelland-St-Pierre Laura , Pham Michael C. , Nguyen Alice Quynh Huong , Pasquet Romain , Taylor Sherryl A. , Bosson-Rieutort Delphine , Koushik Anita , Ho Vikki
Published: February 2024

Supplementary Table S1 shows regression coefficients that denote the difference in average DNA methylation level, as derived from the mean methylation ratios across all estimated CpG sites in the AHRR gene, and their associated 95%CI relative to the reference group. Multivariable models included adjustment for age, sex (not for stratified models), phase of blood sampling, education level, ethnicity, and smoking (CSI - cumulative smoking index). A probability of exposure of 0% was categorized as unexposed; “Possibly exposed” if the probability of exposure was >0% and <25% and “Exposed” to a given agent if the probability of exposure was ≥25%.
Supplementary Figure S2 from The Influence of Smoking and Occupational Risk Factors on DNA Methylation in the AHRR and F2RL3 Genes
Authors: Pelland-St-Pierre Laura , Pham Michael C. , Nguyen Alice Quynh Huong , Pasquet Romain , Taylor Sherryl A. , Bosson-Rieutort Delphine , Koushik Anita , Ho Vikki
Published: February 2024

Supplementary Figure S2 shows, for each graph, the effect estimate and the 95% CI plotted across all 7 CpG sites in the F2RL3 gene. The dotted black line
represents the null. For CSI, the interpretation of the effect estimate is the change in DNA methylation levels per standard
deviation increase in CSI For smoking status (i.e., former and current smokers). Multivariable models included adjustment for
age, sex, phase of blood sampling, education level, and ethnicity. The interpretation of the effect estimate is the difference in
mean methylation level relative to never smokers (reference group). * denotes a p-value < 0.05.
Table S4 from FPFT-2216, a Novel Anti-lymphoma Compound, Induces Simultaneous Degradation of IKZF1/3 and CK1α to Activate p53 and Inhibit NFκB Signaling
Authors: Kanaoka Daiki , Yamada Mitsuo , Yokoyama Hironori , Nishino Satoko , Kunimura Naoshi , Satoyoshi Hiroshi , Wakabayashi Shota , Urabe Kazunori , Ishii Takafumi , Nakanishi Masato
Published: February 2024

Table S4 shows the anti-proliferative effect of MALT1 inhibitor safimaltib in lymphoid tumor cell lines.
Figure S4 from FPFT-2216, a Novel Anti-lymphoma Compound, Induces Simultaneous Degradation of IKZF1/3 and CK1α to Activate p53 and Inhibit NFκB Signaling
Authors: Kanaoka Daiki , Yamada Mitsuo , Yokoyama Hironori , Nishino Satoko , Kunimura Naoshi , Satoyoshi Hiroshi , Wakabayashi Shota , Urabe Kazunori , Ishii Takafumi , Nakanishi Masato
Published: February 2024

Figure S4 shows the genetic characterization of PDX models used in this study.
FIGURE 5 from FPFT-2216, a Novel Anti-lymphoma Compound, Induces Simultaneous Degradation of IKZF1/3 and CK1α to Activate p53 and Inhibit NFκB Signaling
Authors: Kanaoka Daiki , Yamada Mitsuo , Yokoyama Hironori , Nishino Satoko , Kunimura Naoshi , Satoyoshi Hiroshi , Wakabayashi Shota , Urabe Kazunori , Ishii Takafumi , Nakanishi Masato
Published: February 2024

Antitumor activity of FPFT-2216 in CDX and PDX models. FPFT-2216 (10 mg/kg) and siremadlin (100 mg/kg) were administered alone or in combination to mice subcutaneously transplanted with Z-138 cells for three weeks. Tumor volume (A) during the subsequent 3-week washout period and body weight (B) during the treatment period are shown (mean ± SEM, n = 7). **, P < 0.01; ***, P < 0.001 versus vehicle-treated group (Tukey test). C, Tumor volume when FPFT-2216 (1 mg/kg) and rituximab (30 µg/mouse) were administered alone or in combination to mice subcutaneously transplanted with Z-138 cells (mean ± SEM, n = 10). **, P < 0.01 versus vehicle-treated group (Tukey test). D, Tumor volume when FPFT-2216 (0.1 mg/kg) and rituximab (30 µg/mouse) were administered alone or in combination to mice subcutaneously transplanted with DOHH-2 cells (mean ± SEM, n = 5–6). ***, P < 0.001 versus vehicle-treated group, #P < 0.05 versus rituximab-treated group (Dunnett test). E, Cell viability (%) in non-GCB DLBCL patient-derived tumor cells treated with various concentrations of FPFT-2216 for 3 days. Results are presented as mean values (duplicate). F, Tumor volume after administering FPFT-2216 (0.1, 1 mg/kg) or cyclophosphamide (75 mg/kg) to mice subcutaneously transplanted with LYXFDLBC 2835 tumor cells derived from a patient with non-GCB DLBCL (mean ± SEM, n = 6). **, P < 0.01 versus vehicle-treated group (Dunnett test). Each figure (A, C, D, F) shows the time-dependent change in tumor volume of each group until the first individual animal was euthanized. 2216, FPFT-2216; Sire, siremadlin; RTX, rituximab; CPA, cyclophosphamide.
FIGURE 4 from FPFT-2216, a Novel Anti-lymphoma Compound, Induces Simultaneous Degradation of IKZF1/3 and CK1α to Activate p53 and Inhibit NFκB Signaling
Authors: Kanaoka Daiki , Yamada Mitsuo , Yokoyama Hironori , Nishino Satoko , Kunimura Naoshi , Satoyoshi Hiroshi , Wakabayashi Shota , Urabe Kazunori , Ishii Takafumi , Nakanishi Masato
Published: February 2024

Suppression of CBM complex activity/NFκB pathway via CK1α degradation by FPFT-2216. Western blot analysis of DLBCL cell lines (A) and RI-1 cells expressing CK1α G40N mutant (B) cultured for 24 hours in the presence of compounds at different concentrations. Open triangle: Uncleaved BCL10, closed triangle: Cleaved BCL10. C, MG-132 was added after OCI-Ly3 cells were cultured for 23 hours in the presence of compounds at the concentrations shown in the figure. After 1 hour, proteins were extracted from the cells, and Western blot analysis was performed. D, Jurkat cells were cultured for approximately 24 hours in the presence of compounds at the concentrations shown in the figure, and the cells were cultured for 15 minutes after adding PMA/ionomycin. Proteins were extracted from the cells, and Western blot analysis was performed. Representative results from two (B–D) or three (A) independent experiments are shown. GAPDH or α-tubulin was used as a loading control. 2216, FPFT-2216; Lena, lenalidomide; Iber, iberdomide; MALT1i, Z-VRPR-FMK; BAY, BAY 11-7082; Poma, pomalidomide.
FIGURE 1 from FPFT-2216, a Novel Anti-lymphoma Compound, Induces Simultaneous Degradation of IKZF1/3 and CK1α to Activate p53 and Inhibit NFκB Signaling
Authors: Kanaoka Daiki , Yamada Mitsuo , Yokoyama Hironori , Nishino Satoko , Kunimura Naoshi , Satoyoshi Hiroshi , Wakabayashi Shota , Urabe Kazunori , Ishii Takafumi , Nakanishi Masato
Published: February 2024

Antiproliferative activity of FPFT-2216 in lymphoid tumor cell lines. A–D, Cell viability (%) of DLBCL, MCL, FL, BL, and ALL cell lines cultured for three days in FPFT-2216. Results are presented as the mean ± SD (n = 3). E, Western blot analysis of Z-138 cells cultured for 6 hours in the presence of different compounds at the concentrations shown in the figure. Representative results from two independent experiments are shown. GAPDH was used as a loading control. 2216, FPFT-2216; Lena, lenalidomide; Poma, pomalidomide; Avad, avadomide; Iber, iberdomide.
Anti-Vα24Jα18 TCR Antibody Tunes iNKT Cell Responses to Target and Kill CD1d-negative Tumors in an FcγRII (CD32)-dependent Manner
Authors: Takami Mariko , Aoki Takahiro , Nishimura Katsuhiro , Tanaka Hidekazu , Onodera Atsushi , Motohashi Shinichiro
Published: February 2024

Invariant natural killer T (iNKT) cells play an essential role in antitumor immunity by exerting cytotoxicity and producing massive amounts of cytokines. iNKT cells express invariant T-cell receptors (TCR) to recognize their cognate glycolipid antigens such as α-galactosylceramide (α-GalCer) presented on CD1d. We recently reported that iNKT cells recognize CD1d-negative leukemia cell line K562 in a TCR-dependent manner. However, it remains controversial how iNKT cells use TCRs to recognize and exhibit cytotoxic activity toward CD1d-negative tumors cells without CD1d restriction. Here, we report that iNKT cells exerted cytotoxicity toward K562 cells via a carried over anti-Vα24 TCR mAb from positive selection by magnetic bead sorting. We found that addition of the anti-Vα24Jα18 TCR mAb (6B11 mAb) rendered iNKT cells cytotoxic to K562 cells in an FcγRII (CD32)-dependent manner. Moreover, iNKT cells treated with 6B11 mAb became cytotoxic to other CD32+ cell lines (U937 and Daudi). In addition, iNKT cells treated with 6B11 mAb suppressed K562 cell growth in a murine xenograft model in vivo. These data suggest that anti-iNKT TCR mAb treatment of iNKT cells can be applied as a therapeutic strategy to treat CD32+ cancers such as leukemia, lymphoma, and lung cancer.

Significance:

Our findings unveiled that iNKT cells recognize and kill CD1d-negative target tumors via the anti-iNKT TCR mAb bound to CD32 at the tumor site, thereby bridging iNKT cells and CD1d-negative tumors. These findings shed light on the therapeutic potential of anti-iNKT TCR mAbs in NKT cell–based immunotherapy to treat CD1d-negative CD32+ cancers.
Systemic Glucose Regulation by a Hindbrain Inhibitory Circuit in a Mouse Model of Type 1 Diabetes
Authors: Juras J. Anna , Pitra Soledad , Smith Bret N.
Published: February 2024

Introduction: Previous work showed that increasing the electrical activity of inhibitory neurons in the dorsal vagal complex (DVC) is sufficient to increase whole-body glucose concentration in normoglycemic mice. Here we tested the hypothesis that deactivating GABAergic neurons in the dorsal hindbrain of hyperglycemic mice decreases synaptic inhibition of parasympathetic motor neurons in the dorsal motor nucleus of the vagus (DMV) and reduces systemic glucose levels. Methods: Chemogenetic activation or inactivation of GABAergic neurons in the nucleus tractus solitarius (NTS) was used to assess effects of modulating parasympathetic output on blood glucose concentration in normoglycemic and hyperglycemic mice. Patch-clamp electrophysiology in vitro was used to assess cellular effects of chemogenetic manipulation of NTS GABA neurons. Results: Chemogenetic activation of GABAergic NTS neurons in normoglycemic mice increased their action potential firing, resulting in increased inhibitory synaptic input to DMV motor neurons and elevated blood glucose concentration. Deactivation of GABAergic DVC neurons in normoglycemic mice altered their electrical activity but did not alter systemic glucose levels. Conversely, stimulation of GABAergic DVC neurons in mice that were hyperglycemic subsequent to treatment with streptozotocin changed their electrical activity but did not alter whole-body glucose concentration, while deactivation of this inhibitory circuit significantly decreased circulating glucose concentration. Peripheral administration of a brain impermeant muscarinic acetylcholine receptor antagonist abolished these effects. Conclusion: Disinhibiting vagal motor neurons decreases hyperglycemia in a mouse model of type 1 diabetes. This inhibitory brainstem circuit emerges as a key parasympathetic regulator of whole-body glucose homeostasis that undergoes functional plasticity in hyperglycemic conditions.
Síndrome metabólica e a gravidade da COVID-19: uma revisão integrativa
Authors: Kuczera Ana Clara Veiga , Meneghetti Bruna Dupont , Daga Danielle , Fraccanabbia Daniele , Horst Herbert Nagel , Daghetti Kelly Cristina , Walczewski Luis Gustavo Barzotto , Grillo Luciane Peter , Brueckheimer Mônica Ester Krehnke , Cunha Mylena Phillipps , Basso Simone
Published: February 2024

A doença COVID-19 provocada pelo coronavírus SARS-CoV-2 (síndrome respiratória aguda grave Coronavírus-2) representa um desafio à saúde pública global. Evidências mostram que indivíduos que apresentam os componentes da síndrome metabólica tendem a ter um pior prognóstico. A síndrome metabólica é definida como conjunto de distúrbios metabólicos que incluem resistência à insulina, dislipidemia, obesidade central e hipertensão, os quais são fatores de risco para o desenvolvimento de várias doenças crônicas, entre elas o diabetes tipo 2 e doenças cardiovasculares. O objetivo do presente estudo foi revisar integrativamente a literatura sobre o impacto da síndrome metabólica e seus componentes no desfecho dos indivíduos portadores de COVID-19. O presente estudo trata-se de uma revisão integrativa de literatura. Foram selecionados artigos de 2020 e 2021 no Pubmed e Biblioteca Virtual em Saúde usando os descritores: “COVID-19”, “síndrome metabólica” e “adultos”. Os critérios de inclusão adotados foram: artigos primários realizados com adultos; disponíveis na íntegra; nos idiomas português, inglês e espanhol. Inicialmente foram selecionados 372 estudos, em seguida 101 artigos pela leitura dos títulos e após obteve-se 28 pelos resumos, dos quais, após a leitura na íntegra elegeram-se nove para compor a amostra. Por fim, realizou-se a interpretação dos resultados e redação do artigo. Os achados deste estudo concluíram que a associação da síndrome metabólica à COVID-19 acarretam em um pior desfecho clínico. A presença de fatores que compõem a síndrome metabólica esteve relacionada à maior probabilidade de ventilação mecânica, tratamento na unidade de terapia intensiva, falha respiratória, úlceras de pressão e maior risco de mortalidade. Por outro lado, apresentou-se que o HDL pode ser utilizado como marcador de risco para desfechos COVID-19 grave e a relação triglicerídeos/HDL-c como marcador de prognóstico de gravidade. Ademais, a possível multimorbidade presente em pacientes com síndrome metabólica descrita neste estudo corrobora a importância do controle de seus componentes através de ações educativas, metas e controles terapêuticos, por meio da equipe multidisciplinar, para proporcionar uma melhor qualidade de vida.
Mieloma múltiplo com manifestação otológica: relato de caso
Authors: Klostermann Flávia Caroline , Couto Eduardo Vieira , Freitas Lucas Zanon de
Published: February 2024

Introdução: Mieloma múltiplo é uma neoplasia que cursa com a multiplicação desordenada de plasmócitos, produção de imunoglobulina monoclonal e normalmente se apresenta como lesões osteolíticas. As alterações otológicas associadas ao mieloma múltiplo são raras e podem ser confundidas com diversas manifestações crônicas do ouvido. Objetivo: Descrever o caso de um paciente com envolvimento do osso temporal pelo mieloma múltiplo apresentando manifestações otológicas. Método: Relato de caso coletado através de entrevista clínica e com consentimento do paciente por meio da assinatura do termo. Resultado: Paciente do sexo masculino, 74 anos, com sinais de hipoacusia, exame físico sem alterações significativas e audiometria assimétrica, com perda auditiva mista no ouvido esquerdo e neurossensorial no direito. O diagnóstico foi suspeitado por tomografia computadorizada, que mostrou conteúdo hipoatenuante preenchendo as células da mastoide esquerda, com esclerose da cortical óssea interna, sugerindo neoplasia maligna ou distúrbio de absorção do cálcio. Foi encaminhado ao hematologista, que confirmou mieloma múltipo e iniciou tratamento. Considerações para prática do médico generalista: A conscientização de que certas manifestações otológicas podem ser indicativas de condições sistêmicas, como o mieloma múltiplo, ressalta a relevância do médico generalista na detecção precoce e encaminhamento adequado para uma abordagem multidisciplinar.
Le Corbusier 1929: raça no Rio de Janeiro e na América Latina
Authors: Bragaia Flavio Antonio Dugo
Published: February 2024

A partir de uma perspectiva que leva em consideração mecanismos de validação estrangeira sobre a cultura brasileira, este texto dialoga com Eugenics in the Garden [Eugenia no jardim], de Fabíola López-Durán, ao elaborar uma análise sobre a aparente mudança de postura de Lucio Costa diante da participação da população preta na sociedade brasileira. A primeira visita de Le Corbusier ao Rio de Janeiro, em 1929, parece crucial para que Lúcio Costa tenha podido transitar em direção a posições mais afastadas de postulados eugenistas, reproduzindo, a partir da década de 1930, um discurso marcadamente menos racista e machista em relação às décadas anteriores.
A pintura como resistência: Gilles Deleuze intérprete do pintor irlandês Francis Bacon
Authors: Fernandes Carlos Henrique dos Santos
Published: February 2024

O presente ensaio procura mostrar, em caráter introdutório, como a recusa à figuração, na pintura de Francis Bacon, cuja principal consequência pode ser vista na deformação de suas Figuras, pode vincular-se à noção de criação deleuziana como um ato de resistência. Para tanto, num primeiro momento, apresentam-se algumas interpretações fenomenológicas elaboradas por Gilles Deleuze e aplicadas às pinturas do pintor irlandês. Num segundo momento, ao apontar o limite destas interpretações frente aos retratos histéricos pintados por Bacon, busca-se aprofundar a ideia de uma interpretação alternativa que o próprio filósofo francês propõe por meio do conceito de corpo sem órgãos (CsO). Por fim, num terceiro momento, aproximando-se das técnicas pictóricas de Bacon, tenta-se trazer à luz o problema da deformação como um ato de resistência.
As representações do “otário” na lógica da malandragem: uma abordagem comparativa entre cinema e literatura
Authors: Souza Kayah Nicholas de , Novaes Welington Vieira de
Published: February 2024

O presente ensaio propõe-se a uma reflexão sobre as categorias “malandro” e “otário” a partir de uma abordagem comparativa entre o romance “Cidade de Deus” (1997) e o filme “A Vizinhança do Tigre” (2014). Retomando a linha de pensamento sobre o tema, aberta por Antônio Candido, aqui é explorada a tese de que a representação do “otário” nas obras em questão materializa um expoente para violência gerada pela inadequação do malandro na estrutura social. Conclui-se, portanto, que a representação do “ser otário” constitui um território de paz inalcançável, posto que a malandragem propõe a subversão dos ideais desenvolvimentistas por meio da exacerbação da violência.
A Ciscolonialidade e o Transfeminismo
Authors: Silva Gabrielle
Published: February 2024

A cisheteronormatividade é o resultado do processo colonial euro-americano ao redor do globo. Esse processo impôs às sociedades, que anteriormente se organizavam de suas próprias formas, o modelo cisnormativo e binário eurocêntrico, o que acarretou hierarquizações e subjugações de gênero no mundo todo. Entretanto, na atualidade, em algumas culturas a denúncia sobre a não universalidade do modelo europeu está sendo feita e formas de organização anteriores à colonização estão sendo retomadas, com vistas a libertar as sociedades desse sistema de sexo/gênero tão oneroso a todos. Com isso, a partir de revisão bibliográfica discutiremos a tentativa de (re)construção de sociedades em que todos sejam livres para experimentarem e vivenciarem suas identidades, sexualidades e corpas de forma plural. Para tanto, téoricas têm demonstrado que o transfeminismo é ferramenta teórica e prática fundamental no combate ao ciscolonialismo.
Variation in Vessel Size and Angiographic Outcomes Following Stent‐Retriever Thrombectomy in Acute Ischemic Stroke: STRATIS Registry
Authors: Saber Hamidreza , Froehler Michael T. , Zaidat Osama O. , Sultan Ali Aziz , Klucznik Richard P. , Saver Jeffrey L. , Sanossian Nerses , Hellinger Frank R. , Yavagal Dileep R. , Yao Tom L. , Jahan Reza , Haussen Diogo C. , Nogueira Raul G. , Hall Alicia M. , Kronast Nils H. Mueller , Liebeskind David S. ,   for the STRATIS Investigators
Published: February 2024

Background

Mechanical thrombectomy is established for large‐vessel occlusions in acute ischemic stroke, but the potential role in distal vessel occlusions of medium arteries is less well established. Such medium or distal arterial segments have not been assessed with respect to thrombectomy devices used during endovascular therapy. We conducted an analysis of arterial size, segmental anatomy, and stent‐retriever device performance with respect to vessel size during thrombectomy.

Methods

The STRATIS registry angiography core laboratory adjudicated the exact location of the occlusion, proximal, and distal device deployment, relationship to arterial bifurcations, and anatomic nomenclature. Arterial diameters were measured at all these sites. Statistical analyses examined the relationship between vessel and stent size, and arterial recanalization using expanded Thrombolysis in Cerebral Infarction reperfusion score.

Results

Overall, 665 patients with stroke were included following thrombectomy using various Solitaire device sizes, including Solitaire 4×40, Solitaire 6×30, Solitaire 4×20, Solitaire 6×20, and Solitaire 4×15. Arterial diameter at the occlusion site was a median of 2.17 mm (interquartile range [IQR], 1.88–2.60 mm) in the distal M1, 1.67 mm (IQR, 1.47–2.06 mm) in the proximal M2 middle cerebral artery, 1.50 mm (IQR, 1.15–1.61 mm) in the distal M2 middle cerebral artery, 1.24 mm (IQR, 1.11–1.24 mm) in the M3 middle cerebral artery, and 1.88 mm (IQR, 1.49–1.94 mm) in the P1 posterior cerebral artery. Expanded Thrombolysis in Cerebral Infarction 2b to 3 reperfusion was achieved in all M3 or P1 segment occlusions. The rate of first‐pass recanalization was significantly higher in patients with medium (0.75–2 mm) versus large (>2 mm) vessel occlusion (69.5% versus 57.1%;
P
 = 0.003).

Conclusion

Considerable overlap was noted between arterial sizes at occlusion sites carrying different segmental arterial nomenclature or vessel names. Substantial reperfusion may be achieved with currently available mechanical thrombectomy devices in medium arteries.
Secular Spaces in Israel and Turkey
Authors: Uzer Umut
Published: February 2024

This article offers a comparative analysis of Tel Aviv and Izmir based on their urban identities grounded on a secular modernist ideological outlook and a Mediterranean way of life based on egalitarian and democratic norms. These criteria will be operationalized by analyzing the ideological preferences as well possibilities for alternative lifestyles for the residents of both cities. Due to the policies of right-wing governments in both countries, there has been an increasingly overbearing impact of religion in the daily lives of the people and have been undergoing a redefinition of their national identities at the expense of the secular aspects of their national attributes. While a significant number of citizens in both countries have been leaning towards an ethnoreligious worldview, Tel Aviv in Israel and Izmir in Turkey resist such attempts and remain bastions of secularism with their Mediterranean way of life. This study purports to present the similarities and differences between the two cities within their larger conservative setting.
Bark anatomy of Pteroceltis tatarinowii, Cannabaceae
Authors: Chen Bingwei , Kan Yu’na , Zhai Shengcheng , Eder Michaela , Mei Changtong
Published: February 2024

Pteroceltis tatarinowii, a tertiary relic plant, has a long and fascinating history in China due to its irreplaceable role in traditional papermaking. In this study, the anatomical differences between young and old bark were analysed by light microscopy (LM), fluorescence microscopy (FM), and polarized light microscopy (PLM). Both the young and old bark contain periderm, cortex, and phloem. In the non-conducting phloem, the curved radial phloem rays were perpendicular to bands of sieve-tube elements and axial parenchyma cells, forming a net-like pattern. Primary phloem fibres only occurred in young bark, and both primary and secondary phloem fibres contained a gelatinous layer (G-layer). Transmission electron microscopy (TEM) showed that the thickness of the G-layer in the primary phloem fibres was about 1.5–4 times higher than that of the secondary phloem fibres. The thick G-layer might be an important potential reason for the absorption of ink by paper made from P. tatarinowii phloem fibres, due to the good water absorption of the gelatinous layer.
Taxonomic notes on some little known Brazilian Plagiochila (Plagiochilaceae, Marchantiophyta)
Authors: DE SOUZA ALINE MATOS , PERALTA DENILSON FERNANDES , DE BRITO VALENTE EMILIA
Published: February 2024

Here we present several taxonomic notes resulting from taxonomic studies on the Brazilian species of Plagiochila. We are proposing 4 lectotypes and 11 new synonyms, providing taxonomic notes and illustrations of some little-known taxa.
Puparium of Merosargus cingulatus Schiner, 1868 and Ptecticus lanei James, 1941 (Diptera: Stratiomyidae: Sarginae), with new geographical records for the species and a list of all known immatures of the subfamily
Authors: FACHIN DIEGO AGUILAR , AMARAL EDNA MARIA , FALASCHI RAFAELA LOPES
Published: February 2024

The puparia of Merosargus cingulatus Schiner, 1868 and Ptecticus lanei James, 1941, two Neotropical species of Sarginae (Stratiomyidae), are described and illustrated based on 19 and 17 immatures of each species, respectively. The specimens were collected in rotting vegetal material in Carambeí, state of Paraná, Brazil. Images of reared adults of both species are provided, allowing future identifications of specimens. New distributional records include the first occurrences of M. cingulatus in the Brazilian states of Ceará, Maranhão, Mato Grosso do Sul, and Rio de Janeiro. With these two new descriptions, immature stages (6th instar and/or puparium) of 29 species of Sarginae are now known, with only eight species known from the Neotropical Region.
Myanmar endemic Burmorthacris subaptera Kevan, Singh et Akbar, 1964 (Pyrgomorphidae: Orthacridini) rediscovered after 85 years
Authors: SIRICHANTAKUL KAVEE , HMONE ZUNE WIT , KYAW MAR LAR , THANDAR CHO
Published: February 2024

A curious micropteous gaudy grasshopper (family Pyrgomorphidae), Burmorthacris subaptera was described by Kevan, Singh and Akbar in 1964 as a sole member of its genus based on a female and a male collected in Yenangyaung (upper Myanmar) on 27th and 28th August 1937 and which were deposited at the Academy of Natural Sciences of Philadelphia. The species has never been reported since then. The genus Burmorthacris is the northernmost of the Orthacris genus group genera, which includes mostly genera from Sri Lanka and Malaysia. Recently we rediscovered this B. subaptera in its type locality (Yenangyaung township in the Magway Region) in Myanmar, 85 years after the holotype and the paratype were collected in the same place, and furthermore herewith we present one more locality in another region where the species has been found (Nyaung-U township in the Mandalay Region). Due to the lack of basically any information on this species distribution and habitat, including also photographs of its natural coloration in this habitat, the present study provides the first-time photographs of B. subaptera in its natural habitat from both localities, as well as some insights into its morphology, especially coloration, habitat, and behavior.