bluuebunny/crossref_metadata_2025 huggingface dataset:
Nutritional Indices, Phytochemistry, and the In Vitro Antioxidant Activity of Carrot Fortified Tomato Concentrate
Authors: Ademosun Olabisi Theresa , Adebayo Abiodun Humphrey , Ajanaku Kolawole Oluseyi
Published: June 2024

Researchers are constantly looking at the development of functional foods from local materials that offer both nutritional and therapeutic potentials. The study investigated the proximate composition, antioxidant capacity, and phytochemical profile of different compositions of formulations produced from tomato and carrot. The plant materials were sourced locally, dried to a uniform weight, and milled using a mechanical blender. Nutritional indices, viz., proximate analysis, were analyzed using a standard protocol. The phytocompounds present in the formulations and their in vitro antioxidant activities were analyzed using spectrophotometric methods. The results for proximate composition showed low moisture content in formulations (0.44 ± 0.015–0.54 ± 0.021%). The protein content of the formulations (16.51 ± 0.217–17.94 ± 0.134%) was significantly higher than that of carrot alone (8.41 ± 0.154%). Similarly, the crude fat was elevated in the formulations (0.31 ± 0.008–1.63 ± 0.017%) compared to tomato alone (0.10 ± 0.399). However, these values were lower than the values obtained for carrot alone (8.72 ± 0.009%). The energy value for the formulations ranged from 87.01 to 93.30 kcal, which was low compared to carrot alone (136.89 kcal). Phytochemical screening showed the presence of terpenoids, cardiac glycosides, saponins, phenols, flavonoids, and alkaloids in the studied formulations. Furthermore, the incorporation of carrot led to an increase in TPC, TFC, and alkaloid concentration. The pH values observed were around the neutral range, while lactic acid concentrations reduced following the incorporation of carrot. Trace element analysis showed improved iron and manganese concentrations in the formulation. Similarly, increased antioxidant ability was observed in the formulation. For sensory evaluation, reporters indicated good sensory parameters. Concluding, this study has shown that formulating concentrate from tomato and carrot showed improved nutritional potential and enormous antioxidant capacity that can be attributed to the presence of elevated total phenolics and flavonoid concentrations. Therefore, this formulation is warranted for improving the health of mankind.
Abstract A014: Inhibiting eIF4E phosphorylation sensitizes triple-negative breast cancer to CDK4/6 inhibition
Authors: Deng Qiyun , Amiri Mehdi , Piric Anastasija Ana , Bagherian Yasaman , Li Zilan , Huang Sidong , Pollak Michael , Sonenberg Nahum
Published: June 2024

This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR011) of the Conference Program/Proceedings.

Citation Format: Qiyun Deng, Mehdi Amiri, Anastasija Ana Piric, Yasaman Bagherian, Zilan Li, Sidong Huang, Michael Pollak, Nahum Sonenberg. Inhibiting eIF4E phosphorylation sensitizes triple-negative breast cancer to CDK4/6 inhibition [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Expanding and Translating Cancer Synthetic Vulnerabilities; 2024 Jun 10-13; Montreal, Quebec, Canada. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(6 Suppl):Abstract nr A014.
Abstract B015: Combinatorial genetic screens to map synthetic lethal interactions and identify new cancer drug targets in KRAS mutant cancers
Authors: Arafeh Rand , Chang Laura , Sawyer Lydia , Wang Helen , McFarland James , Dempster Joshua , DeWeirdt Peter , Doench John , Hahn William C
Published: June 2024

This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR014) of the Conference Program/Proceedings.

Citation Format: Rand Arafeh, Laura Chang, Lydia Sawyer, Helen Wang, James McFarland, Joshua Dempster, Peter DeWeirdt, John Doench, William C Hahn. Combinatorial genetic screens to map synthetic lethal interactions and identify new cancer drug targets in KRAS mutant cancers [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Expanding and Translating Cancer Synthetic Vulnerabilities; 2024 Jun 10-13; Montreal, Quebec, Canada. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(6 Suppl):Abstract nr B015.
Abstract B020: Novel WRN helicase inhibitors selectively target microsatellite unstable cancer cells
Authors: Picco Gabriele , Rao Yanhua , Al Saedi Angham , Lee Yang , Bhosle Shriram , Herranz-Ors Carmen , Walker Samantha , May Kieron , Coelho Matthew , Houseley Jon , Schwartz Benjamin , Garnett Mathew J.
Published: June 2024

Microsatellite-unstable (MSI) cancers require WRN helicase to resolve replication stress due to expanded DNA (TA)n-dinucleotide repeats. WRN is a promising synthetic lethal target for MSI tumours, and WRN inhibitors are in development. Here, we used CRISPR-Cas9 base editing to map WRN residues critical for MSI cells, validating the helicase domain as the primary drug target. Fragment-based screening led to the development of potent and highly selective WRN helicase covalent inhibitors. These compounds selectively suppressed MSI model growth In vitro and In vivo by mimicking WRN loss, inducing DNA double-strand breaks at expanded TA-repeats and DNA damage. Assessment of biomarkers in preclinical models linked TA-repeat expansions and mismatch repair (MMR) alterations to compound activity. Efficacy was confirmed in immunotherapy-resistant organoids and patient-derived xenograft (PDX) models. The discovery of potent, selective covalent WRN inhibitors provides proof of concept for synthetic-lethal targeting of WRN in MSI cancer and tools to dissect WRN biology.

Citation Format: Gabriele Picco, Yanhua Rao, Angham Al Saedi, Yang Lee, Shriram Bhosle, Carmen Herranz-Ors, Samantha Walker, Kieron May, Matthew Coelho, Jon Houseley, Benjamin Schwartz, Mathew J. Garnett. Novel WRN helicase inhibitors selectively target microsatellite unstable cancer cells [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Expanding and Translating Cancer Synthetic Vulnerabilities; 2024 Jun 10-13; Montreal, Quebec, Canada. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(6 Suppl):Abstract nr B020.
Abstract IA002: Overcoming the K-Ras inhibitor resistant cell state in PDAC with molecular glues.
Authors: Ferguson Fleur M.
Published: June 2024

K-Ras inhibitor resistance in PDAC is associated with metabolic reprogramming towards a high OXPHOS state. Existing inhibitors of components of the electron transport chain have on-target toxicities that limit their use in the clinic, highlighting an opportunity to develop mechanistically orthogonal approaches. In this talk, I discuss our development of molecular glue degraders that target metabolic vulnerabilities in K-Ras inhibitor resistant PDAC.

Citation Format: Fleur M. Ferguson. Overcoming the K-Ras inhibitor resistant cell state in PDAC with molecular glues [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Expanding and Translating Cancer Synthetic Vulnerabilities; 2024 Jun 10-13; Montreal, Quebec, Canada. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(6 Suppl):Abstract nr IA002.
Abstract PR014: Combinatorial genetic screens to map synthetic lethal interactions and identify new cancer drug targets in KRAS mutant cancers
Authors: Arafeh Rand , Chang Laura , Sawyer Lydia , Wang Helen , McFarland James , Dempster Joshua , DeWeirdt Peter , Doench John , Hahn William C.
Published: June 2024

The success of precision oncology depends on our ability to translate accumulating genomic data into actionable treatment options in a personalized manner. The first step requires the identification of a specific genomic signature, then matching this signature with the most effective therapy. Unfortunately, more often than not, we do not have a specific cancer drug that is effective for the mutation found in a specific tumor. We desperately need to identify new targets so that we can develop new drugs to deliver on the promise of precision cancer medicine. In addition, we need to develop a rational way to combine drugs that does not depend on trial and error. Combinatorial genetic screening CRISPR-Cas9 now allows us to identify synthetic lethal interactions in which simultaneous perturbation of two genes leads to cell death. However, multiplex gene editing to reveal these synergies between genes is a major challenge. For model systems like yeast, high-throughput methods and technologies have made it possible to create genetic networks with around 23 million double mutants (6000 genes x 6000 genes) and has resulted in the most detailed genetic interaction network to date consisting of ∼900,000 genetic interactions. This landscape of genetic interaction network of yeast has taken the scientific research community 15 years. In human cells, there are ∼20,000 genes and 400 million combinations, making this very complex network impossible to screen and test all these 400M combinations. To systematically interrogate such genetic interactions, we designed a dual CRISPR-Cas9 perturbation library targeting the top 1000 genes upregulated in KRAS mutant cancers (lung, pancreas and colon cancers). We performed these combinatorial double knockout screens on 100K (100x1000) unique gene pairs and identified 27 pairs whose co-disruption results in a loss of cellular fitness. We next validated those top synthetic lethal pairs of genes by performing secondary screens using CRISPR-Cas12a on more KRAS mutant and KRAS WT cell lines. Overall, our findings will provide insight into potential combinational targets in KRAS mutant tumors and will highlight the synthetic lethality effects that occurs among the novel targets, and other proliferation, metastasis, immune and metabolism modules.

Citation Format: Rand Arafeh, Laura Chang, Lydia Sawyer, Helen Wang, James McFarland, Joshua Dempster, Peter DeWeirdt, John Doench, William C. Hahn. Combinatorial genetic screens to map synthetic lethal interactions and identify new cancer drug targets in KRAS mutant cancers [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Expanding and Translating Cancer Synthetic Vulnerabilities; 2024 Jun 10-13; Montreal, Quebec, Canada. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(6 Suppl):Abstract nr PR014.
Table S3 from Epigenetic Priming by Hypomethylation Enhances the Immunogenic Potential of Tolinapant in T-cell Lymphoma
Authors: Ward George A. , Zhang Zhiqiang , Jueliger Simone , Potapov Ilya S. , Davis Matthew P. , Boxall Adam R. , Taylor Jason , Keer Harold , Biondo Andrea , Lyons John F. , Sims Martin , Smyth Tomoko
Published: June 2024

Table S3. Generation of CRISPR Knockout (KO) and CRISPR Activation (CRISPRa) Cell Line Clones
Table S1 from Epigenetic Priming by Hypomethylation Enhances the Immunogenic Potential of Tolinapant in T-cell Lymphoma
Authors: Ward George A. , Zhang Zhiqiang , Jueliger Simone , Potapov Ilya S. , Davis Matthew P. , Boxall Adam R. , Taylor Jason , Keer Harold , Biondo Andrea , Lyons John F. , Sims Martin , Smyth Tomoko
Published: June 2024

Table S1. Details of primary antibodies used in Western blots in this study (Figures 1,2,4,6 & S1).
Figure S9 from Epigenetic Priming by Hypomethylation Enhances the Immunogenic Potential of Tolinapant in T-cell Lymphoma
Authors: Ward George A. , Zhang Zhiqiang , Jueliger Simone , Potapov Ilya S. , Davis Matthew P. , Boxall Adam R. , Taylor Jason , Keer Harold , Biondo Andrea , Lyons John F. , Sims Martin , Smyth Tomoko
Published: June 2024

Figure S9. Analysis of tumor and plasma samples from EL4-Parental and EL4-C8KO syngeneic model PD studies (Refers to Figure 6)
Figure S4 from Epigenetic Priming by Hypomethylation Enhances the Immunogenic Potential of Tolinapant in T-cell Lymphoma
Authors: Ward George A. , Zhang Zhiqiang , Jueliger Simone , Potapov Ilya S. , Davis Matthew P. , Boxall Adam R. , Taylor Jason , Keer Harold , Biondo Andrea , Lyons John F. , Sims Martin , Smyth Tomoko
Published: June 2024

Figure S4. Changes in DNA methylation levels after decitabine (DAC) treatment of human TCL cell lines. (Refers to Figure 2)
Figure S10 from Epigenetic Priming by Hypomethylation Enhances the Immunogenic Potential of Tolinapant in T-cell Lymphoma
Authors: Ward George A. , Zhang Zhiqiang , Jueliger Simone , Potapov Ilya S. , Davis Matthew P. , Boxall Adam R. , Taylor Jason , Keer Harold , Biondo Andrea , Lyons John F. , Sims Martin , Smyth Tomoko
Published: June 2024

Figure S10. Impact of tolinapant and decitabine on induction of immunogenic cell death in TCL. (Refers to Discussion)
Figure S1 from Epigenetic Priming by Hypomethylation Enhances the Immunogenic Potential of Tolinapant in T-cell Lymphoma
Authors: Ward George A. , Zhang Zhiqiang , Jueliger Simone , Potapov Ilya S. , Davis Matthew P. , Boxall Adam R. , Taylor Jason , Keer Harold , Biondo Andrea , Lyons John F. , Sims Martin , Smyth Tomoko
Published: June 2024

Figure S1. Additional Western blots showing different CRISPR clones generated from each construct. (Refers to Figure 1)
FIGURE 5 from Epigenetic Priming by Hypomethylation Enhances the Immunogenic Potential of Tolinapant in T-cell Lymphoma
Authors: Ward George A. , Zhang Zhiqiang , Jueliger Simone , Potapov Ilya S. , Davis Matthew P. , Boxall Adam R. , Taylor Jason , Keer Harold , Biondo Andrea , Lyons John F. , Sims Martin , Smyth Tomoko
Published: June 2024

Pharmacodynamic changes in ICD biomarkers, chemokines/cytokines, and gene expression in models of TCL in vivo and in patients. A, Western blots of tumor lysates from a BW5147 tumors grown in wild-type mice. Tumor-bearing animals were treated with five daily doses of each compound alone or in combination then culled 2 hours after the final dose. B, Changes (log2 fold change relative to vehicle control) in a panel of 43 chemokine/cytokines measured by Luminex assay in plasma of the treated animals. C, Protein analysis by Western blots and of lysates from Karpas-299 tumors in CB17 SCID mice. Tumors were taken after three daily doses of each compound alone or in combination. D, Relative expression by qPCR analysis from RNA extracted from tumors taken after three daily doses of compounds as described in C. Signal for each gene was normalized to the level of 18S housekeeping as control. * Indicates an estimation of relative expression because this gene was not detected in vehicle control (vehicle control CT set to 40). E, Histogram showing relative change in IP-10 levels. The data are represented as log2 fold change in PTCL patient (n = 63 patients) between early times in C1 and late times in cycle C1. “Early” refers to pretreatment and 2 hours posttreatment samples; “late” refers to mostly day 2 (after the first dose), day 7, and day 8 at the end of 7 daily doses in C1. F, Longitudinal data showing relative plasma IP-10 levels in patients during the first two cycles. C1 (as described above) pattern was repeated during cycle 2 (C2). Cycle 2 was initiated 7 days after the last tolinapant administration. P values from binomial one-tailed test.
FIGURE 4 from Epigenetic Priming by Hypomethylation Enhances the Immunogenic Potential of Tolinapant in T-cell Lymphoma
Authors: Ward George A. , Zhang Zhiqiang , Jueliger Simone , Potapov Ilya S. , Davis Matthew P. , Boxall Adam R. , Taylor Jason , Keer Harold , Biondo Andrea , Lyons John F. , Sims Martin , Smyth Tomoko
Published: June 2024

Increased levels of IFN signaling components and changes in ICD biomarkers or chemokines/cytokines on treatment of TCL cell lines with decitabine and tolinapant. A, Western blots of mouse BW5147 cell lysates prepared after 48 hours treatment with different concentrations of decitabine without and with 1 µmol/L tolinapant. B, IFNγ MSD assay of H9 cell supernatants collected after 48 hours treatment with different concentrations of decitabine. C, log2 fold increase (relative to DMSO control) in 41 chemokines/cytokines from BW5147 cell supernatants taken 48 hours after treatment with 1 µmol/L DAC, 1 µmol/L tolinapant, or a combination of both measured by Luminex assay. D, Data from C showing raw data for IP-10 (CXCL10) levels. E, HMGB1 ELISA assay of BW5147 cell supernatants collected after 24 hours treatment with different concentrations of decitabine with 0, 0.1, or 1 µmol/L tolinapant.
FIGURE 1 from Epigenetic Priming by Hypomethylation Enhances the Immunogenic Potential of Tolinapant in T-cell Lymphoma
Authors: Ward George A. , Zhang Zhiqiang , Jueliger Simone , Potapov Ilya S. , Davis Matthew P. , Boxall Adam R. , Taylor Jason , Keer Harold , Biondo Andrea , Lyons John F. , Sims Martin , Smyth Tomoko
Published: June 2024

Effect of necrosome protein expression in TCL cell lines on tolinapant-induced cell death. A, Western blots of parental BW5147, RIPK3−/− BW5147 and MLKL−/− BW5147 cell lysates (untreated). B, Cytotox-NIR signal captured by real-time microscopy (IncuCyte), detecting membrane permeabilization during lytic cell death after treatment of parental BW5147, RIPK3−/− BW5147 and MLKL−/− BW5147 cells with tolinapant in the absence or presence of zVAD. C, Western blots of Karpas-299 cells transduced with control gRNA (KARPAS-299-CTR gRNA) or with RIPK3 gRNA (KARPAS-299-RIPK3 gRNA) constructs treated with tolinapant ± zVAD for 0, 2, or 6 hours. D, Real-time microscopy (IncuCyte) measurement of membrane permeabilization by measuring Cytotox-NIR signal after treatment of KARPAS-299-CTR gRNA or KARPAS-299-RIPK3 gRNA cells with tolinapant. E, Western blots of EL4-PAR and CASP8 KO EL4 (EL4-C8KO) cell lysates after 24-hour treatment with tolinapant. F, Real-time microscopy (IncuCyte) measurement of membrane permeabilization by measuring Cytotox-NIR signal after treatment of EL4-PAR or EL4-C8KO cells with tolinapant.
Keuangan Personal: Perencanaan Investasi dan Pajak
Authors: Indrawati Nur Khusniyah , Juwita Himmiyatul Amanah Jiwa , Djazuli Atim
Published: June 2024

Pengeloaan keuangan seseorang ditunjukkan dengan perilaku dalam membelanjakan uangnya. Banyak pengeluaran yang dilakukan tidak secara bijaksana, yaitu tidak pada need melainkan lebih banyak didasarkan pada want sehingga pendapatan yang diterima seseorang lebih banyak dialokasikan untuk komsumsi dan kurang memperhatikan tabungan, investasi, dan asuransi untuk persiapan kehidupan di masa mendatang. Selain itu, perilaku hedonisme juga berdampak pada munculnya masalah keuangan dalam kehidupan seseorang sehingga financial trade-offnya condong kepada pengeluaran lebih banyak untuk konsumsi yang memberi kebahagiaan sesat dibandingkan dengan kesejahteraan di kemudian hari. Strategi mengelola uang juga penting untuk dilakukan seseorang dan menjadi bagian yang dibahas dalam buku ini. Target dari materi ini adalah diketahuinya kekayaan bersih seseorang dan hasilnya dapat menjadi bahan evaluasi dalam pengeluaran uang. Untuk itu, dalam buku ini dibahas tentang penyusunan laporan keuangan personal dan arus kas, seperti Neraca Personal, Laporan Arus Kas Personal, dan Anggaran Kas Personal. Buku ini menjadi dasar dalam menyusun perencanaan keuangan personal terutama dalam pemilihan instrumen investasi atau tabungan. Instrumen investasi ini dapat berupa aset fisik seperti, tanah, rumah, real estate lainnya, logam mulia, permata, dan barang-barang koleksi yang mempunyai nilai tinggi; dan aset nonfisik/keuangan seperti saham, obligasi, reksa dana. Pemilihan instrumen investasi ini dipengaruhi oleh profil risiko seseorang. Profil risiko (sangat konservatif, konservatif, moderat, dan agresif) yang dimiliki seseorang ini kemudian mengarahkan seseorang untuk memilih portofolio investasinya. Terbitnya buku Keuangan Personal: Perencanaan Investasi dan Pajak ini sangat dibutuhkan oleh mahasiswa Fakultas Ekonomi dan Bisnis serta masyarakat yang berminat untuk berinvestasi di instrumen keuangan dan mengisi kekosongan literatur terutama dalam edisi Bahasa Indonesia yang sangat dibutuhkan. Guna melengkapi pemahaman dalam berinvestasi, buku ini juga dilengkapi dengan pembahasan pajak sesuai dengan jenis istrumen keuangan yang dipilih. Buku Keuangan Personal: Perencanaan Investasi dan Pajak ini disusun dan ditulis dengan bahasa yang mudah dipahami, lengkap, disajikan secara jelas, dan mudah dipahami karena disertai contoh-contoh yang sangat jelas dan latihan-latihan yang diberikan baik kualitatif maupun kuantitatif. Terbitnya buku ini akan menambah khazanah ilmu pengetahuan dan menjadi referensi yang sangat berguna di bidang keuangan khususnya keuangan personal.
Ekonomi Pembangunan Perdesaan dan Pertanian
Authors: Nugroho Tri Wahyu , Toiba Hery , Rahman Moh. Shadiqur , Putritamara Jaisy Aghniarahim , Andriatmoko Novil Dedy , Priyanto Moh. Wahyudi , Wijayanti Dian Eswin
Published: June 2024

Buku “Ekonomi Pembangunan Pertanian dan Perdesaan” membawa pembaca dalam sebuah perjalanan mendalam ke dunia ekonomi pertanian dan pembangunan perdesaan. Dalam buku ini, pembaca diajak memahami konsep dasar ekonomi pembangunan perdesaan, dimulai dari definisi yang mendasari pembangunan ekonomi di wilayah pedesaan. Penulis mengurai teori-teori pembangunan ekonomi, mulai dari aliran klasik hingga pendekatan post-keynesian, memberikan landasan teoretis yang kuat bagi pembaca. Bab-bab selanjutnya menggali potensi livelihood capital dalam konteks perdesaan, merinci permasalahan yang dihadapi pembangunan perdesaan, termasuk kemiskinan, kerawanan pangan, ketimpangan, dan populasi perdesaan. Penekanan diberikan pada sektor pertanian sebagai tulang punggung pembangunan ekonomi perdesaan. Karakteristik pertanian Indonesia dan kondisi pertanian perdesaan saat ini dipaparkan secara mendalam, memberi pembaca wawasan yang komprehensif. Buku ini juga membahas kontribusi sektor pertanian dalam pembangunan ekonomi perdesaan, mencakup aspek penyerapan tenaga kerja, ketersediaan pangan nasional, dan pengembang devisa. Pembaca diajak memahami tahapan pembangunan pertanian, syarat-syaratnya, dan strategi modernisasi pertanian. Inovasi teknologi dan pengembangan infrastruktur di perdesaan juga menjadi fokus utama, dengan analisis mendalam tentang infrastruktur perdesaan, pertanian, dan nonpertanian. Penulis membahas pentingnya kelembagaan dalam pembangunan perdesaan, memberikan gambaran tentang peran kelembagaan perdesaan serta kebijakan pemerintah dalam mendukung pembangunan tersebut. Pengembangan kawasan pertanian dan konsep pertanian berkelanjutan juga turut menjadi sorotan dalam buku ini. Pembaca dipandu melalui tahapan kerja kawasan pengembangan pertanian, menyaksikan bagaimana konsep ini diimplementasikan di lapangan. Buku ini juga menyajikan analisis mendalam mengenai kebijakan pemerintah dalam pembangunan pertanian, membahas kebijakan pembangunan perdesaan, kebijakan saat ini dalam pembangunan perdesaan, serta dampak kebijakan terhadap pertumbuhan ekonomi perdesaan dan sektor pertanian. Buku ini diakhiri dengan kesimpulan yang menggali inti dari seluruh pembahasan, memberikan gambaran menyeluruh tentang dinamika ekonomi pembangunan pertanian dan perdesaan di Indonesia. Dengan konten yang mendalam dan analisis yang tajam, buku ini merupakan sumber rujukan yang berharga bagi para pembaca yang tertarik dalam studi ekonomi pertanian dan pembangunan perdesaan, serta para praktisi dan pengambil kebijakan yang bergerak dalam bidang ini.
Mikro Intermediet dan Penerapannya
Authors: Asmara Rosihan , Hanani Nuhfil , Fahriyah Fahriyah , Nugroho Condro Puspo , U`la Mahfudlotul
Published: June 2024

Buku “Mikro Intermediet dan Penerapannya” ini membawa pembaca ke tingkat pengetahuan yang lebih mendalam dalam ilmu mikroekonomi. Dengan pendekatan yang jelas dan terstruktur, buku ini membahas konsep-konsep dalam mikroekonomi yang membantu pembaca memahami perilaku ekonomi individu, perusahaan dan pasar. Mulai dari persamaan slutsky, intemporal choice, surplus konsumen, permintaan pasar, ekuilibrium, maksimisasi keuntungan, minimisasi biaya, kurva biaya, pasokan perusahaan dan industri, pasar monopoli, oligopoli, game theory, ekternalitas, hingga asimetri informasi, buku ini merinci berbagai aspek mikroekonomi dengan contoh-contoh praktis. Penekanan diberikan pada aplikasi konsep-konsep ini dalam pengambilan keputusan ekonomi sehari-hari. Buku ini cocok untuk mahasiswa dasar hingga menengah maupun praktisi dalam bidang pendidikan yang ingin memperdalam pemahaman mereka tentang mikroekonomi. Dengan bahasa yang mudah dipahami dan contoh yang relevan, “Mikro Intermediet dan Penerapannya” menjadi panduan yang berharga dalam memahami dinamika ekonomi mikro.
Mapeamento colaborativo em caso de desastres: análise da qualidade de dados do OpenStreetMap e o ciclone Idai em Moçambique
Authors: Joaquim Idalécio Pascoal , Machado Adriana Alexandria , Camboim Silvana Philippi
Published: June 2024

Em 2019, a Cidade da Beira em Moçambique foi assolada pela passagem do ciclone tropical Idai, deixando 90% da cidade destruída com mais de 600 vítimas fatais e milhares de pessoas necessitando de serviços essenciais de saúde. O mapeamento sistemático do país está desatualizado e com cobertura desigual, o que torna difícil a tomada de decisão face à vulnerabilidade constante do país a eventos como este. O mapeamento colaborativo do OpenStreetMap (OSM) tem sido considerado como alternativa em caso de ausência de mapas oficiais. Em caso de desastres, os contribuidores da organização Humanitarian OpenStreetMap Team (HOT) se unem para gerar dados geoespaciais de modo imediato para apoiar o resgate e assistência às populações desalojadas. Moçambique foi beneficiado com 64 campanhas de mapeamento humanitário, que produziram dados vitais para a preparação para os próximos desastres. Este artigo apresenta um método para avaliar os parâmetros intrínsecos de qualidade dos dados OSM produzidos entre 2015 e 2019 para a Cidade da Beira e analisar a influência das campanhas da HOT nas atividades relacionadas ao ciclone Idai. A análise dos resultados mostra que, apesar do grande volume de dados obtido, a maior parte deles foi gerada por usuários de outros países, carecendo de toponímia e da inclusão das comunidades locais. Esta experiência mostra a importância do estabelecimento de comunidades locais de mapeadores como a rede YouthMappers, para que seja fomentada a criação e uso de dados espaciais colaborativos para a preparação e resposta a desastres em contraponto ao colonialismo de dados.
Um caso de oligotimia na clínica psicopedagógica
Authors: Munimos Silvia Szterling
Published: June 2024

Sob o império das neurociências, das terapias comportamentais e da medicalização na infância, a clínica dos distúrbios de aprendizagem inaugurada por Sara Pain está em desuso. A compreensão da função da ignorância na articulação do triângulo pai-mãe-filho e os significantes que a representam não encontram mais eco nos cursos de formação em psicopedagogia. O estudo de caso que aqui se apresenta, de um adolescente com problemas de aprendizagem e graves impasses na sua constituição subjetiva, pretende revisitar esse saber fazer psicopedagógico que media entre o conhecimento e o saber. Indiretamente, denuncia a falácia do discurso da inclusão escolar, que ao desconhecer a dimensão do inconsciente, dificulta ao educando assumir outra posição subjetiva que não a de “deficiente”.
Formação de professores sob o paradigma tecnocrático: implicações sobre a palavra professoral
Authors: Mourão Elaine Cristina
Published: June 2024

A formação de professores é tomada como variável chave no enfrentamento das mazelas de nossa educação. Essa forma de tomar a questão é simplista por desconsiderar diversas variáveis que interferem na problemática, culpabiliza os professores ao mesmo tempo em que dá destaque para premissas técnico-didáticas. Por esta razão, tomamos as implicações do imperialismo racionalista e utilitarista na interpelação da palavra professoral que ressalta que há lógicas mais didáticas do que outras. Para tanto, elegemos como material de pesquisa as obras São deuses os professores? O segredo dos professores de sucesso de Patrícia Patrício (2005), Aula nota 10: 49 técnicas para ser um professor campeão de audiência de Doug Lemov (2011), Professores e professauros: reflexões sobre a aula e práticas pedagógicas diversas de Celso Antunes (2013), os documentários Être et avoir (Ser e ter) de 2002, dirigido por Nicolas Philibert e Mon maître d’école de 2016, dirigido por Émilie Thérond e o filme Les grands esprits (O melhor professor da minha vida) de 2017, dirigido por Olivier Ayache-Vidal. A partir de reflexões psicanalíticas na educação, apontamos o intuito do discurso pedagógico hegemônico de tornar o professar psiquicamente “de graça” e que as condições de possibilidade da mestria passam pela implicação e engajamento no professar, já que o endereçamento da palavra educativa requer tomar distanciamento de modelos idealizados e universalizantes sobre a docência.
“Elegia de verão” de Manuel Bandeira: Entre a metalinguagem e a intertextualidade
Authors: Gomes Julia Pinheiro
Published: June 2024

A partir do poema “Elegia de verão” de Manuel Bandeira que parece estar em diálogo com o soneto “O sol é grande, caem co’a calma as aves” do poeta do renascimento português Sá de Miranda, este artigo pretende apresentar dois conceitos essenciais, que podem ser observados na poesia daquele autor brasileiro: a metalinguagem e a intertextualidade.
As muitas versões de um mesmo relato: o jogo narrativo de O Manual dos Inquisidores, de António Lobo Antunes.
Authors: Bezerra Ana Cristina Pinto
Published: June 2024

A análise pretendida deseja compreender como se realiza o “jogo narrativo” presente no romance O manual dos inquisidores (1996), de Lobo Antunes, percebendo de que forma a realização estético-formal e sua multiplicidade de vozes, observada na prosa, dialogam com o universo histórico e social com o qual o Manual se relaciona. Assim deseja-se perceber como as vozes significam o contexto social vivenciado e para além dele, como vozes aglutinadas em um mesmo “relato”.
A condição humana e o espaço: aspetos da composição das personagens centrais dos romances Fogo morto (1943) e Ilhéu de contenda (1978)
Authors: Pinto Bruna Carolina de Almeida
Published: June 2024

Este trabalho pretende refletir sobre as personagens centrais dos romances Fogo morto (1943), do escritor brasileiro José Lins do Rego, e Ilhéu de contenda (1978), do cabo-verdiano Henrique Teixeira de Sousa, a partir de suas relativas perspectivas sobre os espaços narrados e o modo pelo qual estes se projetam em suas consciências desencadeando um desajuste existencial.
Inteligência artificial em saúde
Authors: Amaro Junior Edson , Nakaya Helder , Rizzo Luiz Vicente
Published: June 2024

AI in healthcare is a reality. Its possible applications in areas such as diagnosis, research and interface between providers and patients are already in use, even without the certainty that, in their current configuration, they present advantages for patients, providers or society. The possibilities, especially for generative AI, are immense. However, rigorous studies must be conducted to validate its use, no different from those that apply to any advancement in healthcare. The near future will bring advances in the use and frontiers of this technology. In this text we describe some of the uses and possibilities of AI in healthcare, whether in its results, in research or in management.
Over the Prison Wall
Authors: Denner Michael
Published: June 2024

When writing his short-story “The Lion and the Dog”, Lev Tolstoy begins his creative process by establishing a tense intertextuality with the fable’s conventions by challenging the traditional approach to this genre. The present article seeks to understand the object by considering Tolstoy’s narrative technique in the light of Nietzsche’s critique of language and Shklovsky’s concept of defamiliarizing. As a result, the paper brings out the peculiarities of Tolstoy’s work, such as his subversion of moralizing tropes and a sketch of the philosophical implications of his work.
Tolstói contra a idolatria shakespeariana
Authors: Vaz Valteir
Published: June 2024

This review presents the main ideas of Leo Tolstoy’s assay On Shakespeare and on Drama.
Leituras cruzadas. Espinosa e Marx
Authors: Gainza Mariana de
Published: June 2024

Neste artigo procuramos tensionar o campo de leituras contemporâneas de Espinosa segundo dois eixos: um que considera a forma mais ou menos explícita em que o intérprete invoca o nome do filósofo; outro que, partindo dos encontros entre espinosismo e marxismo, assinala diversos posicionamentos na polêmica em torno da contradição. Aproveitando esses cruzamentos, seria possível conceber outra ideia da contradição que, tendo em conta as críticas que apontaram seus efeitos mistificadores, possa servir para pensar a complexidade dos processos políticos contemporâneos?
Por que a dialética se aventura? a história, a política, a liberdade e seus caminhos tortuosos
Authors: Siviero José Marcelo
Published: June 2024

Ao propor uma dialética aberta a aventuras (ou seja, a contingências e acasos), trataremos nesse artigo de desvendar o porquê dessa noção de aventuras que Merleau-Ponty atribui ao termo dialética, tão caro em várias tradições e correntes filosóficas. Ao retomar a noção chave de preconceitos clássicos, Merleau-Ponty descobre duas formas análogas de política assentadas sobre o pensamento objetivo, as políticas de razão e as de entendimento, nas quais o papel do acaso e das contingências políticas é claramente excluído. Ora, é ao analisar Max Weber (no primeiro ensaio da obra supracitada), em suas considerações acerca da relação entre religião e economia (protestantismo e capitalismo) que Merleau-Ponty aponta os caminhos e as fissuras pelas quais a contingência se infiltra na dialética histórica e constrói, com o auxílio dos acasos e dos imprevistos, uma percepção da política e da liberdade.
Natureza e história: notas sobre a crítica à noção abstrata de natureza humana em Marx e Vico
Authors: Pereira Filho Antonio José
Published: June 2024

O artigo analisa a ruptura na obra de Marx e de Vico em relação à concepção abstrata de natureza humana. Apesar dos objetos e objetivos serem distintos em ambos os filósofos, eles coincidem na crítica a esta noção, uma vez que esta recusa é inseparável da concepção que os dois filósofos têm do homem como ser histórico e social.
Leo Strauss e o pretenso “Materialismo Ateu”
Authors: Rocha André Menezes
Published: June 2024

Analisaremos uma leitura antimarxista da obra de Espinosa. Com uma escrita sedutora, Strauss pretende mostrar que a subversão de Espinosa consistia em propagar, sob a forma do ensinamento oculto, o “materialismo ateu”. Ora, esta imagem, como se sabe, nos tempos da guerra-fria era forjada pela propaganda anticomunista. O método de Leo Strauss é guiado pelo conceito do político de Carl Schmitt que foi elaborado em polêmica mortal contra o liberalismo político e o socialismo para dar fundamentos “ontológicos” à teoria das elites. Sob a aparência de desvendar o ensinamento subversivo oculto da filosofia de Espinosa, Leo Strauss sobrepõe-lhe um sentido que lhe é estranho, impõe-lhe uma marca que não é sua e inaugura, quiçá de maneira oculta, uma nova matriz para leituras antimarxistas da obra. Neste artigo analisamos o método e alguns resultados da leitura que Leo Strauss propõe para o Tratado Teológico-Político de Espinosa.
Impaired Cardiac AMPK (5′‐Adenosine Monophosphate‐Activated Protein Kinase) and Ca
2+
‐Handling, and Action Potential Duration Heterogeneity in Ibrutinib‐Induced Ventricular Arrhythmia Vulnerability
Authors: Zhao Yanan , Du Beibei , Chakraborty Praloy , Denham Nathan , Massé Stéphane , Lai Patrick F.H. , Azam Mohammed Ali , Billia Filio , Thavendiranathan Paaladinesh , Abdel‐Qadir Husam , Lopaschuk Gary D. , Nanthakumar Kumaraswamy
Published: June 2024

Background

We recently demonstrated that acute administration of ibrutinib, a Bruton's tyrosine kinase inhibitor used in chemotherapy for blood malignancies, increases ventricular arrhythmia (VA) vulnerability. A pathway of ibrutinib‐induced vulnerability to VA that can be modulated for cardioprotection remains unclear.

Methods and Results

The effects of ibrutinib on cardiac electrical activity and Ca
2+
dynamics were investigated in Langendorff‐perfused hearts using optical mapping. We also conducted Western blotting analysis to evaluate the impact of ibrutinib on various regulatory and Ca
2+
‐handling proteins in rat cardiac tissues. Treatment with ibrutinib (10 mg/kg per day) for 4 weeks was associated with an increased VA inducibility (72.2%±6.3% versus 38.9±7.0% in controls,
P
<0.002) and shorter action potential durations during pacing at various frequencies (
P
<0.05). Ibrutinib also decreased heart rate thresholds for beat–to–beat duration alternans of the cardiac action potential (
P
<0.05). Significant changes in myocardial Ca
2+
transients included lower amplitude alternans ratios (
P
<0.05), longer times‐to‐peak (
P
<0.05), and greater spontaneous intracellular Ca
2+
elevations (
P
<0.01). We also found lower abundance and phosphorylation of myocardial AMPK (5′‐adenosine monophosphate‐activated protein kinase), indicating reduced AMPK activity in hearts after ibrutinib treatment. An acute treatment with the AMPK activator 5‐aminoimidazole‐4‐carboxamide‐1‐β‐D‐ribofuranoside ameliorated abnormalities in action potential and Ca
2+
dynamics, and significantly reduced VA inducibility (37.1%±13.4% versus 72.2%±6.3% in the absence of 5‐aminoimidazole‐4‐carboxamide‐1‐β‐D‐ribofuranoside,
P
<0.05) in hearts from ibrutinib‐treated rats.

Conclusions

VA vulnerability inflicted by ibrutinib may be mediated in part by an impairment of myocardial AMPK activity. Pharmacological activation of AMPK may be a protective strategy against ibrutinib‐induced cardiotoxicity.
Two new species and new distribution records of robber flies (Diptera: Asilidae) from the Altai Republic (Russia)
Authors: SAKHVON VITAL
Published: June 2024

The data on the robber flies of the Altai Republic (Russia) is provided based on the results of expeditions in 2016 and 2022 and the study of museum material. Two new species, Neomochtherus proshchalykini sp. nov. and Leptogaster nikiforovi sp. nov. are described and illustrated. Currently the fauna of robber flies of the Altai Republic includes 35 species and four subspecies, with Antiphrisson mongolicus Lehr, Antiphrisson niger Lehr, Ktyr callarus callarus Lehr, Ktyr protensis Lehr and Leptogaster bivittata Lehr recorded from Russia for the first time. A key to males of Leptogaster Meigen, 1803 species from Siberia is provided.
Description of two new species of Haliplectus Cobb, 1913 (Nematoda, Plectida, Haliplectidae) from mangrove areas of Sandspit backwater, Karachi, Pakistan
Authors: WAHEED SAMINA , DECRAEMER WILFRIDA , KAZI NASIRA , TARIQ RAJPUT MUHAMMED , IQBAL ERUM
Published: June 2024

Haliplectus shahinae n. sp. and H. sandspitensis n. sp. two free-living marine nematodes of the family Haliplectidae Chitwood, 1951 collected from mangrove areas of Sandspit backwater, Karachi, Pakistan, are being described and illustrated. Both new species belong to a group of species characterized by the presence of a bipartite basal esophageal bulb with striated or unstriated valve plates. H. shahinae n. sp. is characterized by its comparatively shorter body length (0.4–0.44 mm); annulated cuticle; amphidial fovea at 6–9 µm from the anterior end; bipartite basal bulb with unstriated valve plates; reproductive system mono-prodelphic with reflexed ovary, presence of post uterine sac and vulva at 52–57% of body length and tail short conoid, straight, 1.5–1.8 times anal body width long. H. sandspitensis n. sp. is characterized by more than 1 mm body length (1.0–1.2 mm); annulated cuticle; amphidial fovea at 8–12 µm from the anterior end; bipartite basal bulb with striated valve plates; didelphic reproductive system, with the vulva at 40–47% of body length and tail elongated, conoid, 1.4–2.2 times anal body width long. A dichotomous identification key is provided for the valid species of Haliplectus Cobb, 1913.
The genus Adelius Haliday, 1833 in the fauna of Korean Peninsula (Hymenoptera: Braconidae: Cheloninae: Adeliini)
Authors: BELOKOBYLSKIJ SERGEY A. , LEE HYE-RIN , KU DEOKSEO
Published: June 2024

The species of the genus Adelius Haliday, 1833 found in the Korean Peninsula are reviewed. A new species Adelius myriolus sp. nov. is described and illustrated. The illustrated redescription of Adelius amplus Belokobylskij, 1998 and a key to four known Korean Adelius species are provided.
Effect of Spacing of Elephant Grass Intercropping with Alfalfa on Biomass Yield and Nutritive Value of Elephant Grass in Fedis District, Eastern Ethiopia
Authors: Bekuma Worku , Zewdu Tessema , Girma Meseret
Published: June 2024

The study was conducted by Fedis Agricultural Research Center (FARC) at Boko station in Fedis district. The experiment consisted of three different spacing arrangements: S1 (100 cm x 50 cm), S2 (75 cm x 50cm) and S3 (50 cm x 50 cm), and two cropping systems (intercrop and sole planting). These treatments were combined in a 3 x 2 factorial arrangement using a randomized complete block design with four replications. Forage samples were collected at ninety (90) days for elephant grass and 10% flowering for Alfalfa. The results showed that spacing and the interaction between spacing and intercropping had a significant (p<0.05) effect on herbage dry matter yield (DMY) and crude protein yield (CPY) of elephant grass. However, intercropping had no significant (p>0.05) effect on herbage DMY and CPY. Intercropping can increase the yield of herbage dry matter and total herbage dry matter when compared to pure stand elephant grass. The yield advantage can be up to 3.18% and 19.65%, respectively. Spacing does not significantly affect the dry matter yield of Alfalfa, but the cropping system does. Intercropping and narrow spacing resulted in higher total dry matter yield, due to the additive effect of intercropped Alfalfa dry matter yield. Among the three different spacing, the narrowest spacing S3 recorded the highest dry matter yield (25.62 t/ha), followed by S2 (22.28 t/ha) and S1 (18.33 t/ha). Spacing and intercropping have no significant effect on the chemical composition of elephant grass, but intercropping can increase the dry matter and decrease the ash content of elephant grass. Farmers in the study area and other regions with similar agro-ecology are advised to consider intercropping Alfalfa two weeks after establishing elephant grass. This should be done at an inter and intra-row spacing of 50 cm to achieve a higher herbage dry matter yield for both, elephant grass and total forage.
Women and Agricultural Entrepreneurship in Rural Areas in West Africa: Case of Benin
Authors: Kegnide Eyitayo , Vodouhe Fifanou , Egbendewe Aklesso , Yabi Jacob
Published: June 2024

This research identified factors that can influence the forms of women's entrepreneurship in rural areas in Benin. The Harmonized Survey on Living Conditions of Households database carried out in 2018 was used for the study. Data in several countries (Benin, Burkina Faso, Côte d'Ivoire, Guinea Bissau, Mali, Niger, Senegal, Togo) and financed by the World Bank. The annual survey to monitor the living conditions of households is part of the perspective of a better knowledge of poverty in WAEMU member countries, in order to understand its manifestations. This Data were submitted to a multinomial logistic regression model and, rural women in agricultural entrepreneurship were categorized into three groups based on sources of funding: entrepreneurship with access to credit (1.70%), entrepreneurship in association (17.88%), and entrepreneurship with equity (80.42%). The regression model identified factors such as socio-cultural affiliation, religion, geographical location, age, marital status, and the mother's branch of activity as social factors that determine the choice of forms of entrepreneurship. In addition to these factors, the study identified some constraints on women's agricultural entrepreneurship such as lack of employment, lack of access to land, level of education, access to water and grazing sites, floods/droughts, poor management, and poor sales of agricultural products as exogenous factors. Improvement of these factors could promote women's agricultural entrepreneurship in rural areas.
No Optimal Weight to Survive the Winter in a Northern Island Population of Water Voles Arvicola amphibius
Authors: Frafjord Karl
Published: June 2024

Growth and body size of mammals are commonly correlated with many life history strategies, including those related to survival and reproduction. However, in certain circumstances suboptimal growth rates and smaller size may be advantageous and adaptive. The water vole Arvicola amphibius is a large vole, about three times the size of a field vole Microtus agrestis, but with similar ecological and reproductive characteristics. Island populations were studied on the coast of northern Norway, just below the Arctic Circle, during 2003-2018, by capture-mark-recapture. The main aims were to study growth rates, asymptotic weight and survival, expecting that the “optimal” weight for surviving the winter would be 140-160 g. The smallest juveniles caught weighed only 21 g and were assumed, based on data from the literature, to be around 14 days old. This age was used as starting point for the growth curve. This, however, may have been about one week too early, as juveniles are more likely not fully weaned and leave their nest of birth until 30-40 g. Initial growth rates in juveniles was relatively high but declined from around 100-120 g or 40-50 days old. The asymptotic weight was not clearly defined, but its maximum was around 150-160 g. Most juveniles that survived the winter weighed between 100 and 160 g in their first summer. Large individual variations in growth rates were found. Overwintered subadults in spring weighed about the same as juveniles did in the autumn but grew quickly in April and May to reach adult size. A specific “optimal” weight for juveniles that survived the winter was not found. The range could be given as 100-160 g, too broad to define an “optimal” weight range. However, those that survived tended to be slightly heavier than those that died. Reproducing adults generally weighed 180-220 g and did not reduce their weight toward the autumn, i.e., to increase winter survival, but very few adults survived even the summer and almost none survived their second winter. Juveniles postponed reproduction until next spring, most likely to take advantage of fresh vegetation growth and less competition.
Empirical Assessment of African Oil Bean Husk as a Fluid-Loss Control Agent in Oil-Based Drilling Mud
Authors: Ikpeseni Sunday , Ogbue Michael , Okoh Ifeanyi , Ekpu Mathias , Edomwonyi-Otu Lawrence
Published: June 2024

Efficiency of drilling mud is partly determined by filtrate loss. In this article, research on suitability of African oil bean husk (AOBH), as a fluid loss control additive for oil-based drilling mud (OBM) is presented. Dry AOBH of particle sizes 63µm, 125µm and 250µm were used. Fourier Transform Infrared Spectrophotometer (FTIR) and Phenom Prox model of the Scanning Electron Microscope energy dispersive X-ray spectroscopy (SEM-EDS) were used to determine morphology and chemical properties of AOBH. OBM samples were prepared using the various sizes of AOBH as fluid-loss control additives and Grel Alphatex as industrial grade additives. Power Law Model and Herschel-Bulkley Models were used to model rheology of samples. Results show that AOBH contains mainly asphaltic compounds, is eco-friendly and biodegradable. Results from mud tests show close values in performances of AOBH and industrial grade. Filter cake thickness was 2.1mm – 2.8mm for AOBH-additives mud, but 2.3mm for industrial-additives mud. Filtrate loss was 2.0ml – 3.4ml for AOBH-additives mud, but 2.3ml for industrial-additives mud. Apparent viscosity for AOBH-additives mud was 77.5 -92.0cp, but 99.0cp for industrial–additives mud. Plastic viscosity for AOBH-additives mud was 73.0 - 81.0cp, but 87.0cp for industrial-additives mud. Yield point for AOBH-additives mud was 9.0 – 22.0, but 24.0 for industrial-additives mud. Both models show that efficiency of the mud containing AOBH in cleaning hole increased as grain size of AOBH reduced.