bluuebunny/crossref_metadata_2025 huggingface dataset:
Estabilización de suelos arcillosos aplicando ceniza de cáscara de arroz para el mejoramiento de subrasante, en la localidad de Moyobamba – departamento de San Martín
Authors:   , López Barbarán Junior
Published: July 2021

La utilización de ceniza de cáscara de arroz (CCA) puede reducir el gran problema ambiental asociado a su inadecuada disposición. Una forma, es su adición en suelos arcillosos, lo que puede brindar soluciones a los problemas de estabilización, aumentando así su capacidad de soporte del suelo. El presente proyecto de investigación tiene como finalidad la estabilización de suelos arcillosos aplicando ceniza de cáscara de arroz para el mejoramiento de subrasante en la localidad de Moyobamba- departamento de San Martín; donde se obtuvo un suelo de arcilla inorgánica de alta plasticidad siendo su clasificación SUCS “CH” y AASHTO “A-7-6 (20)”. Se realizó ensayos estandarizados de mecánica de suelos, tales como Análisis Granulométrico, Límites de Atterberg, Proctor Modificado y California Bearing Ratio (CBR) con combinaciones de ceniza de cáscara de arroz (CCA) de 5%, 10% y 15%. En el ensayo de CBR la resistencia obtenida al 95% de la Máxima Densidad Seca del suelo natural es de 3,96%, añadiendo el 5% de CCA la resistencia es de 6,90%, con 10% de CCA es de 9,60% y para el 15% de CCA es de 10,5 %, por lo que la investigación concluye que el uso de ceniza de cáscara de arroz (CCA) como material estabilizante de suelos arcillosos brinda buenos resultados.
Evidencias Psicométricas de la Escala de Autoestima Corporal en adolescentes
Authors:   , Adrianzén Rey Katherin Junayda , Palmer Apaza Lourdes Antonia
Published: July 2021

La presente investigación tuvo como objetivo validar la Escala de Autoestima Corporal (EAC) de Peris, Maganto y Garaigordobil (2016) en estudiantes de tercero a quinto grado de secundaria de Lima Metropolitana. Este estudio se realizó con un enfoque cuantitativo de tipo instrumental con una muestra de 692 estudiantes (45.66% mujeres y 54.34% varones) de 13 a 17 años de edad pertenecientes a instituciones educativas particulares y públicas. La validez convergente se comprobó con la Escala de Autoestima de Rosenberg (EAR), en la versión peruana de Ventura-León, Caycho-Rodríguez y Barboza-Palomino (2018). Los resultados del análisis factorial exploratorio validaron la existencia de 5 subescalas que se relacionan entre sí, estás son: satisfacción corporal (ω=.90), atractivo corporal (ω =.88), cara (ω =.63), torso inferior (ω =.86) y torso superior (ω=.76). En relación a los resultados del análisis factorial confirmatorio, el modelo 3 revela mejores índices de ajuste en comparación con los otros modelos. Los resultados del M3 fueron: chi cuadrado (x2 = 698.76), grados de libertad (gl= 214), índices comparativos (CFI= .97), el índice Tucker-Lewis (TLI= .97), la raíz residual estandarizada cuadrática media (SRMR= .04) y el error cuadrático medio de aproximación (RMSEA = .08). En conclusión, la EAC cuenta con evidencia empírica basada en el contenido, en la estructura interna, en relación con otra variable y fiabilidad, la cual puede ser aplicada a adolescentes como una prueba de screening para detectar el riesgo de problemas de autoestima corporal, tanto en el aspecto cognitivo como en el aspecto emocional.
Desarrollo de la identidad homosexual en universitarios de Lima Metropolitana
Authors:   , Oviedo Bedoya María José
Published: July 2021

Objetivo: Busca comprender el desarrollo de la identidad sexual homosexual en universitarios de Lima Metropolitana a partir de sus historias de vida. Método: Participaron 8 homosexuales entre 21 y 29 años seleccionados por bola de nieve, los cuales fueron 4 hombres y 4 mujeres. Asimismo, es un estudio cualitativo con diseño hermenéutico en el que se realizaron conversaciones sobre sus experiencias relacionadas a su sexualidad. El análisis de dichas conversaciones, se realizó mediante la propuesta metodológica de Gonzalez (2008) y se establecieron 4 ejes basados en la teoría de Troiden (1989) para explicar el desarrollo de la identidad homosexual. Resultados: Sensibilización: Los participantes, durante su infancia, se reconocieron como distintos a los demás; sin embargo, solo se dieron cuenta en la adolescencia al mirar al pasado. Confusión de identidad: Surgieron sentimientos negativos basados en la mirada de la sociedad a los homosexuales. Asunción de identidad: Es esta etapa comenzó la aceptación a raíz de la cercanía a personas LGBT. Compromiso: En todos los casos se logró la aceptación por parte de la familia. Conclusiones: El desarrollo de la identidad homosexual se ve influenciado por el entorno familiar y social. Asimismo, la revelación favorece sentimientos de bienestar y libertad.
AKULTURASI BUDAYA JAWA DAN MELAYU PADA UPACARA PERNIKAHAN DI DESA SRI MENANTI KECAMATAN TANJUNG LAGO KABUPATEN BANYUASIN
Authors: Aswar Budi , Rochmiatun Endang , Suriana Sri
Published: July 2021

This research departs on the phenomenon of acculturation of Indonesian culture. Indonesia is famous for its cultural diversity. The cycle of life starting from birth, marriage and death are all regulated in culture. Marriage is an anthropological study that sees marriage as a culture. This study uses an anthropological approach and uses the redfied theory, namely acculturation. Furthermore, this study uses a qualitative descriptive method. The results of this discussion can be in several points. 1). Marriage is a sacred ritual in life, 2). The influence of social contact makes the acculturation process run well with some of the same values ​​of harmony, 3). Javanese and Malay weddings have differences in rituals although there are similarities and slightly different pronunciations. 4). Acculturation includes pre-wedding, wedding day and post-wedding.
Optimalisasi penggunaan Learning Management System (LMS) dalam pembelajaran virtual untuk guru di lingkungan Lembaga Pendidikan Ma’arif NU Jember
Authors: Mahbub Moh. Arif
Published: July 2021

[Bahasa]: Pemberlakuan pembelajaran jarak jauh (PJJ) daring (dalam jaringan) akibat krisis pandemi global Covid-19 di Indonesia memberikan tantangan tersendiri khususnya bagi para pendidik. Kesiapan kompetensi guru dalam mengelola kelas daring dan kemampuan beradaptasi dengan moda pembelajaran virtual menjadi faktor kunci keberhasilan PJJ daring tersebut. Namun, data empiris menunjukkan ketidaksiapan para guru dalam mengimplemen-tasikan PJJ daring ini. Program pengabdian kepada masyarakat ini bertujuan untuk mengoptimalkan penggunaan Edmodo dalam PJJ daring. Kegiatan ini diikuti oleh 32 peserta yang merupakan para guru yang mengajar dilingkungan LP Ma’arif NU cabang Jember. Prosedur pelaksanaan program pengabdian ini terdiri dari tiga tahap yaitu eksplorasi, elaborasi, dan konfirmasi. Hasil pengabdian menunjukkan adanya respon yang sangat positif dari para peserta pelatihan terkait integrasi Edmodo dalam PJJ daring. Selanjutnya, simpulan, keterbatasan, dan rekomendasi hasil program pengabdian didiskusikan dalam artikel ini.

Kata Kunci: Edmodo, learning management system (LMS), pembelajaran jarak jauh, pembelajaran virtual

[English]: Online learning during Covid-19 outbreak in Indonesia has seriously challenged the teachers. The teachers’ competencies in managing their online courses and the level of adaptability to virtual learning environments are both crucial factors to a successful online learning. However, empirical data demonstrate the low levels of readiness regarding the implementation of this online learning. As an attempt to resolve this problem, this community service program aims to optimize the use of Edmodo in online learning. Thirty-two teachers from Ma’arif Nahdlatul Ulama Educational Institution (LP Ma’arif NU) in Jember voluntarily participated in this program. The program was held in three phases; exploration, elaboration, and confirmation. It is found that the participants mostly have positive feelings about the integration of Edmodo into online learning. Furthermore, the conclusions, limitations, and recommendations of the program results are discussed in this article.

Keywords: Edmodo, learning management system (LMS), virtual learning, distance learning
PENERAPAN MODEL PEMBELAJARAN EDUTAINMENT BERDASARKAN QUANTUM TEACHING UNTUK MENINGKATKAN MOTIVASI DAN HASIL BELAJAR IPA SISWA KELAS IXB PADA MATERI PEWARISAN SIFAT
Authors: Rahayu Dwi Nastiti
Published: July 2021

Penelitian ini bertujuan untuk meningkatkan motivasi dan hasil belajar IPA melalui penerapan pembelajaran edutainment berdasarkan Quantum Teaching dengan kerangka rancangan TANDUR pada Materi  Pewarisan Sifat Kelas IXB di SMP Negei 10 Banjarmasin, dilaksanakan dalam dua siklus, siklus I terdiri atas dua kali pertemuan dan siklus II terdiri atas dua kali pertemuan, penelitian ini dilaksanakan dari bulan Juli  sampai dengan Oktober pada semester Ganjil tahun ajaran 2014-2015. Subjek penelitian adalah siswa Kelas IXB SMP Negei 10 Banjarmasin yang berjumlah 34 siswa, terdiri dari 15 siswa perempuan dan 19 siswa laki-laki. Datal penelitian diperoleh dengan menggunakan  instrumen tes akhir siklus, lembar observasi penilaian afektif dan psikomotor, lembar observasi keberhasilan tindakan, angket motivasi belajar siswa, dan catatan lapangan. Berdasarkan hasil penelitian diketahui bahwa penerapan pembelajaran edutainment berdasarkan Quantum Teaching dengan kerangka rancangan TANDUR dapat meningkatkan motivasi dan hasil belajar siswa. Peningkatan motivasi belajar siswa ditunjukkan dengan peningkatan skor rata-rata yang didapat, di mana pada siklus I menunjukkan hasil sebesar 3,46 dengan kategori cukup  dan meningkat pada siklus II sebesar 3,7 dengan kategori baik. Peningkatan skor rata-rata motivasi belajar diikuti juga dengan meningkatnya ketuntasan klasikal, di mana pada siklus I sebesar 35,9% dan meningkat pada siklus II sebesar 82,1%. Peningkatan hasil belajar dapat diketahui dari ranah kognitif dengan ketuntasan belajar siswa sebesar 85% menjadi 92%. Peningkatan pada ranah afektif dapat dilihat dari persentase keberhasilannya, di mana pada siklus I sebesar 82,29% dan meningkat pada siklus II sebesar 83,33%. Peningkatan pada ranah psikomotor dapat dilihat dari persentase keberhasilannya, di mana pada siklus I sebesar 65,63% dan meningkat pada siklus II sebesar 78,12%.Kata kunci: kerangka rancangan TANDUR, motivasi belajar, hasil belajar.
KERAGAMAN JENIS VEGETASI DI KAWASAN RAWA TANPA POHON DESA BATI-BATI KABUPATEN TANAH LAUT SEBAGAI MATERI PENGAYAAN MATERI MATA KULIAH EKOLOGI LAHAN BASAH
Authors: Hardiansyah Hardiansyah , Noorhidayati Noorhidayati , Mahrudin Mahrudin
Published: July 2021

Rawa merupakan istilah umum yang digunakan untuk semua daerah yang tergenang air baik secara musiman maupun permanen dan memiliki keragaman flora dan fauna yang khas. Rawa di Kalimantan  terdapat kurang lebih sebesar 10,56 juta ha, dan di Kalimantan Selatan terdapat kurang lebih 235,677 ha. Salah satu rawa tersebut adalah rawa tanpa pohon, yang juga terdapat di Desa Bati-Batiyang didominasi oleh rumput-rumputan dan herba aquatik lainnya.Rawa tanpa pohon salah satunya di Desa Bati-Bati Kecamatan Bati-Bati Kabupaten Tanah Laut, yang data keragaman jenis vegetasi di kawasan tersebut berpotensi digunakan sebagai sumber belajar Ekologi.Tujuan penelitian ini adalah mengetahui keragaman jenis vegetasi rawa tanpa pohon di Desa Bati-Bati Kabupaten Tanah Laut, dan membuat handout pengayaan Materi Matakuliah Ekologi Lahan Basah yang valid.Metode yang digunakan adalah metode deskriptif, berupa penelitian lapangan untuk mengetahui keragaman vegetasi rawa tanpa pohon dan penelitian pengembangan untuk membuat bahan ajar berupa handout.Hasil penelitian didapatkan 12 jenis yaitu Vetiveria zizanoides (bundung), Leersia hexandra (banta), Panicum virgatum (kumpai batu), Eleocharis palustris (purun), Eleocharis acicularis (rumput purun), Eleocharis dulcis (purun tikus), Ludwegia hyssopifolia (pipisangan), Leptochlea caerulencens (parupuk),  Nyampheae pubescens (batang tanding), Ipomea aquatic (kangkung), Cynodon dactylon (rumput jarum) dan Mikania scandens (kangkung pagar).dan Indeks Diversitas (H’) sebesar 1,5544 dikategorikan keanekaragaman sedang. Validitas bahan ajar handout tentang keanekaragaman vegetasi di kawasan rawa tanpa pohon Desa Bati-bati kabupaten Tanah Laut sebagai pengayaan materi mata kuliah Ekologi Lahan Basah adalah sangat valid.Kata Kunci: Keanekaragaman, Vegetasi, Rawa tanpa Pohon, Handout
ТЕХНІЧНЕ ЗАБЕЗПЕЧЕННЯ ПЕРИОПЕРАЦІЙНОЇ КЕРАТОМЕТРІЇ ПРИ ІМПЛАНТАЦІЇ ІНТРАОКУЛЯРНИХ ЛІНЗ
Authors: Поліщук Олександр Сергійович , Козяр Василь Васильович
Published: July 2021

Дана робота присв’ячена проектуванню та послідуючій технічні реалізації прилада, що придатний до використання в сфері офтальмології. Розроблений кератометр на який отримано патент UA 120893 та акт впровадження. Для реалізації прилада було залучено різні допоміжні засоби, такі як: середовища SolidWorks, LabView, 3Ds max та 3D принтер Anet A8. Перед вибором форми кілець для проекції, було проаналізовано три типи їх розміщення, а саме, площинне, від’ємне конусне та від’ємне параболоїдне розміщення. Програма 3Ds max застосована для просліддковування ходу променів світла після проходження концентричних кілець. В приладі міститься плата Arduino Micro на базі процесора ATmega32u4. Дана плата дає можливість приводити прилад в поступальний рух за допомогою джойстика. Рух по горизонталі передбачений для можливості фокусування камери, що міститься в приладі та для більш точного проведення діагностичної процедури. Кератометр дає змогу провести вимірювання передньої поверхні рогівки ока людини в різних меридіанах. Значення, які отримуються при цьому, оцінються в міліметрах та виводяться в спеціальне вікно програми. Інформацію зручно зберігати на будь якому інформаційному накопичувачу. Маючи дані про нормальну рогівку за допомогою розробленої програми в середовищі LabVIEW та маркерів, що проставляються на отриманому зображенні, можливо діагностувати стан передньої поверхні ока, а саме рогівки. Згідно дослідження, що було проведене на чотирьох добровольцях, отримано інформацію, що три з них мають певне відхилення від норми, а саме, астигматизм та кератоконус. Даний висновок був зроблений на основі експертного рішення та інформації отриманої від інших авторів в цій області. Прилад може бути використаним для проведення до та після операційної діагностики, а також, як засіб отримання даних, необхідних для підбору інтраокулярної лінзи. Слідуючими удосконаленнями, які плануються, має бути додання можливості діагностики інших структур ока людини. Такими структурами є задня стінка рогівки ока, райдужна оболонка та кришталик із задньою та передньою стінками капсули.
Ключові слова: ІОЛ; інтраокулярна лінза; кератометр; астигматизм; катаракта; LabView; SolidWorks; 3D друкg.
РОЗРОБКА ОФТАЛЬМОЛОГІЧНОГО ЛАЗЕРНОГО ПРИСТРОЮ
Authors: Богомолов М. , Данилець М.
Published: July 2021

Сучасна діагностика захворювань очного дна потребує застосування найбільш довершеного обладнання. Коло застосування лазерів в офтальмології дуже широке, а типи лазерних джерел – різноманітні. При цьому і частка лазерних установок для офтальмології серед загального промислового випуску лазерів досить велика. Ведеться активна робота по залученню джерел когерентного випромінювання з якісно новими характеристиками. Використання мультихвильового лазерного джерела розширює коло можливих застосувань в лікуванні захворювань ока. Маючи можливість вибирати з декількох довжин лазерного випромінювання, що відрізняються за своїми характеристиками проникнення в тканини ока, мультихвильовий пристрій дозволяє фахівцям оптимізувати довжину хвилі, яка максимально поглинається цільовим хромофором і мінімально поглинається іншими хромофорами. В результаті забезпечується індивідуальне лазерне лікування з оптимальним клінічним результатом і мінімальними побічними ефектами. Тому актуальною є розробка багатофункціонального діагностичного та терапевтичного пристрою для лікування очних захворювань. У даній роботі представлено розроблені принципові схеми блоку накачки лазера та блоку живлення офтальмологічного пристрою.
Ключові слова: мультихвильове випромінювання, лазер, лазерна терапія, лазерна діагностика, офтальмологія, хоріоідея.
КЛІТИННІ ТЕХНОЛОГІЇ ОТРИМАННЯ ТЕРАПЕВТИЧНИХ МОНОКЛОНАЛЬНИХ АНТИТІЛ
Authors: Чорний С. , Луценко Т.
Published: July 2021

Розвиток розробки та виробництва терапевтичних моноклональних антитіл набирає значних обертів завдяки високим показникам безпечності та ефективності. В даній сфері відбувається стрімкий ріст на світовому ринку на рівні 150 млрд доларів у 2019 році, і десятки нових препаратів вже пройшли етап розробки та активно проходять клінічні дослідження. У статті проведено аналітичний огляд базових технологій отримання терапевтичних моноклональних антитіл з оцінкою переваг та недоліків. Розглядаються технології починаючи з “традиційної” гібридомної технології з високою імуногенністю отримуваних препаратів, до повністю людських моноклональних антитіл. Також у статті проаналізовано критичні етапи виробництва, що включають отримання клону-продуцента, культивування, виділення та очистку антитіл.

Ключові слова: терапевтичні моноклональні антитіла, гуманізовані та химерні антитіла, рекомбінантні білки, гібридомна технологія, фаговий дисплей, виробництво
PLANNING CITY TOURISM DEVELOPMENT: PRINCIPLES AND ISSUES
Authors: Smolčić Jurdana Dora , Sušilović Zrinka
Published: July 2021

Contemporary trends on the world tourism market show that the number of tourists attracted by the cities in growing. Urban tourism is a growing tourism market and especially are attractive the cities in Europe. The cities as an important tourist destinations came of age during 1980s. The local governments came to recognize that tourism could have a role in urban economic development. The invisibility of tourism in cities partly arises from the fact that many facilities are used both by residents and visitors. Improving these facilities therefore provides benefits for local residents as well as assisting the promotion of tourism. City tourism development plan should be prepared as an integral part of global economic and social development plan of the city, with the main aim to integrate the tourism in existing urban economic development, and at the same time to prevent conflict situations. Tourism development in the city needs a network and cooperative relationships between local government, tourist organization, tourist agencies and different organizations/institutions in the city; public-private partnership is a must. In the paper are analyzed the main attributes, principles and goals of the tourism in the cities.
THE IMPACT OF NATIONAL CULTURE ON THE CORPORATE CULTURE IN GLOBAL HOTEL COMPANIES
Authors: Cerović Zdenko , Tomašević Amelia
Published: July 2021

The national culture is a system of assumptions, values, norms and traditions shared by one national group; the corporate culture is a system of rituals, behavior patters, norms and values shared by majority of employees in a company. Both cultures influence the style of management and communication with employees. The national culture influences the corporate culture, but in a long term, a corporate culture can also influence the national culture. Strong corporate cultures can suppress the national culture through the system of standardization of business operations, which in international companies is an element of brand identification and a competitive advantage. Global hotel companies which manage the hotels all over the world, face problems which derive from differences between their own corporate culture and national cultures of local staff. The efficiency of operations will depend on the way and skills in handling those problems. The influence of national and sometimes local cultures might have positive impact on creation of very successful hotel system of hotel service which often is well accepted on tourist market, but might also result with potential misunderstandings and even opposite effects. The paper surveys the elements of national cultures which might have impact on corporate cultures. The paper assumes that global hotel companies often face big cultural and social differences in certain destinations of their business interest. The model of survey are hotel corporate cultures in Croatian, European and world hotels and their corporations.
How Turkey’s creative professionals see their TV drama industry
Authors: Gül Ayşen
Published: July 2021

Turkey’s TV drama industry has made a quantum leap in the past decade and exported many of its dramas (dizis) to more than a hundred countries. Turkey has become the world’s second-biggest TV drama exporter after the USA in 2016. The dizi industry’s transnationalization is attributable to the tireless efforts and unique features of its associated creative industry. However, the industry has some deep problems. This paper seeks to shed light on the challenges that the Turkish TV drama industry faces. The author has conducted in-depth interviews with Producers, Directors, Scenarists, Actors and Distributors. Their replies reveal the basic characteristics and difficulties of the dizi industry and provide clues as to what needs to be done to sustain and build upon the Turkish TV drama industry’s export success.
Sequestering Biomass for Natural, Efficient, and Low-Cost Direct Air Capture of Carbon Dioxide
Authors: Amelse Jeffrey , Behrens Paul K.
Published: July 2021

Many corporations and governments aspire to become Net Zero Carbon Dioxide by 2030-2050. Achieving this goal requires understanding where energy is produced and consumed, the magnitude of CO2 generation, and the Carbon Cycle. Many prior proposed solutions focus on reducing future CO2 emissions from continued use of fossil fuels. Examination of these technologies exposes their limitations and shows that none offer a complete solution. Direct Capture technologies are needed to reduce CO2 already in the air. The best way to permanently remove CO2 already in the atmosphere is to break the Carbon Cycle by growing biomass from atmospheric CO2 and permanently sequestering that biomass carbon in landfills modified to discourage decomposition to CO2 and methane. Tree leaves and switchgrass are proposed as good biomass sources for this purpose. Left unsequestered, leaves decompose with a short Carbon Cycle time constant releasing CO2 back to the atmosphere. Leaves can represent a substantial fraction of the total biomass generated by a tree when integrated over a tree’s lifetime. The cost for Carbon Capture and Storage (CCS) for growing and sequestering high yield switchgrass is estimated to be lower than CCS for steam reforming of methane hydrogen plants (SRM) and supercritical or combined cycle coal power plants. Thus, sequestration of biomass is a natural, carbon efficient, and low-cost method of Direct Capture. Biomass sequestration can provide CO2 removal on giga tonnes per year scale and can be implemented in the needed timeframe (2030-2050).
Positive Impact of Fibronectin in Stimulation Human Adipose-derived Mesenchymal Stem Cells Attachment Seeded Into Polytetrafluoroethylene Patch for Future Surgical Closure of Atrial and Ventricular Septal Defect
Authors: Suryawan I Gde Rurus , Ratri Anudya Kartika , Andrianto Andrianto , Ardiana Meity , Nugraha Ricardo Adrian
Published: July 2021

Background. Polytetrafluoroethylene (PTFE) patch is commonly used during surgical closure for atrial septal defect (ASD) and/or ventricular septal defect (VSD). It has several limitations such as inability to grow, repair, and remodel. Aneurysm formation, thrombosis, and the inability of patches to grow or remodel are usual, especially in children and young adults. To tackle these limitations, we try to use fibronectin and human adipose-derived mesenchymal stem cells (hAMSCs) in PTFE patch. Objective. To understanding positive impact of fibronectin to enhance hAMSCs cell-to-cell adherence and cell-to-patch surface attachment into PTFE patch for future ASD or VSD closure. Methods. Cultured of hAMSCs cells were fixated with 15 mL methanol and CD90+, CD105+, CD45- antibodies were labeled FITC, rinsed with PBS and analyzed under fluorescence microscope for 15 minutes. Fibronectin solution 0.1% were used to soak patch scaffolds for approximately 2 hours duration, and then dried for 20 minutes for treatment group. As for control group, Fibronectin solution was not added on the culture. The samples were examined with scanning electron microscope (SEM). Results. SEM examination showed incomplete attachment of the cells even after 10 days on control group at 1.14 ±1.13 (Figure 2). In contrast, treatment group showed more cells attached to the patch surface at 31.25 ±13.28 (p 0.000) (Figure 3). Observation at 5 days was 17.67 ± 20.21, at 7 days was 12.11 ± 10.94, at 10 days was 18.83 ± 23.25. No significant statistical difference of mean cell per view among each treatment group (p 0.802). Conclusion. Fibronectin has a positive impact on hAMSCs attachment seeded onto PTFE patch. These properties, in combination with their developmental plasticity, have generated tremendous interest because of the potential use of hAMSCs in regenerative medicine to replace damaged tissues.
In-situ MIMO-WPT Recharging of UAVs Using Intelligent Flying Energy Sources
Authors: Hoseini Sayed Amir , Hassan Jahan , Bokani Ayub , Kanhere Salil S.
Published: July 2021

The Unmanned Aerial Vehicles (UAVs), used in civilian applications such as emergency medical deliveries, precision agriculture, wireless communication provisioning, etc., face the challenge of limited flight time due to their reliance on the on-board battery. Therefore, developing efficient mechanisms for in-situ power transfer to recharge UAV batteries hold potential in extending their mission time. In this paper, we study the use of far-field wireless power transfer (WPT) technique from specialized, transmitter UAVs (tUAVs) carrying Multiple Input Multiple Output (MIMO) antennas for transferring wireless power to receiver UAVs (rUAVs) in a mission. The tUAVs can fly and adjust their distance to the rUAVs to maximize energy transfer. The use of MIMO antennas further boost the energy reception by narrowing the energy beam toward the rUAVs. The complexity of their dynamic operating environment increases with the growing number of tUAVs, and rUAVs with varying levels of energy consumption and residual power. We propose an intelligent trajectory selection algorithm for the tUAVs based on a deep reinforcement learning model called Proximal Policy Optimization (PPO) to optimize the energy transfer gain. Simulation results demonstrate that with the use of PPO, the system achieves a tenfold flight time extension compared to no wireless recharging. Further, PPO outperforms the benchmark movement strategies of ’Traveling Salesman Problem’ and ’Low Battery First’ when used by the tUAVs.
The impact of visualization tools in distance english language learning: the experience of the russian university teachers
Authors: Golubeva Tatyana Ilinichna , Skudnyakova Elena Vladimirovna , Kasatkina Natalia Nikolaevna , Dandanova Svetlana Vladimirovna , Dagbaeva Oxana Innokentyevna
Published: July 2021

The article is aimed at a detailed examination of the prerequisites for the introduction of visual content into the educational process in the foreign language course during distance learning and at defining a list of prerequisites for its successful processing by students. The article proves that the search for new trends and approaches to education leads to new goals and new types of knowledge. All innovations in higher education contribute to the formation of a new image of future professionals. The relevance of the problems of higher education technologization is associated with the countless number of innovations, among which the authors single out the visualization of educational information in distance learning. The article shows the importance of visualization in distance education. The given technology includes both visual presentations of information and the development of visual thinking during the educational process. Educational material and an effective visual teaching method allow making the educational process interesting and non-standard and increasing students’ motivation to learn English. Thus, the visualization of educational information is a tool for distance learning technology. The article identifies the preferable visualization tools based on the survey of students based on the results of the use of visualization in distance English language learning. According to the summary of the results of distance English language learning, it is proposed to divide the visualization process into several stages.
INSTITUTIONAL ENVIRONMENT FOR REPRODUCTION AND DEVELOPMENT
OF HUMAN CAPITAL OF BELARUS
Authors: BOBROVA A. , SHCHERBINA N. , PETRAKOVA Yu.
Published: July 2021

The article describes institutional aspects of the human capital development, identifies
key social institutions that form the institutional environment for human capital reproduction and development.
CONSTRUCTION AS ECONOMIC ACTIVITY
Authors: HOLUBAVA V.
Published: July 2021

In the context of science and technology development, the market saturation and increase of customer requirements for construction projects, construction is considered as economic activity. It allows: 1) to show that the main goal of the development of the construction complex is a creation of modern energy-efficient and resource-saving, ecologocally safe, accessible and comfortable buildings and structures; 2) to justify the need taking into account in the definition of the construction an increase in the habitat’s qualitative characteristics; 3) clarify the notion of "construction as economic activity" and introduce into the turnover "qualitative characteristics of the habitat".
COMPARATIVE ANALYSIS OF THE RESULTS OF MODERNIZATION
OF THE LARGEST ECONOMIES OF ASIAN COUNTRIES
Authors: BIN' CH.
Published: July 2021

The article introduces the comparative analysis of modern industrial compounds
in China, Singapore, South Korea and Japan in the past decades. In this particular focus on the effects of efficiency on the general trend of industrial structure upgrading in the country, install them. Dynamics research based on the growth rate of labor productivity and labor remuneration policy conclusion powerful vitality in China and application of the industrialization of the modern state mechanisms, improve its efficiency.
Construction and directional evolution of anti-enrofloxacin ScFv antibody for the immunoassay of fluoroquinolones
Authors: Wang Fangyu , Li Ning , Zhang Yunshang , Sun Xuxefeng , Zhao Yali , Hu Man , Fan Jianming
Published: July 2021

A recombinant anti-enrofloxacin single-chain antibody (scFv) was produced for the detection of enrofloxacin. An immunized mouse phage display scFv library with a capacity of 2.35×109 CFU/mL was constructed and used for anti-enrofloxacin scFv screening. After four rounds of bio-panning, 10 positives were isolated and identified successfully. The highest positive scFv was expressed in E. coli BL21. Then, its recognition mechanisms were studied using the molecular docking method. The result showed the amino acid residues Leu121 were the key residues for the binding of ScFv to ENR. Based on the results of virtual mutation, the ScFv antibody was evolved by directional mutagenesis of contact amino acid residue Leu121 to Asn. After the expression and purification, an indirect competitive enzyme-linked immunosorbent assay (IC-ELISA) based on the parental and mutant ScFv were established for enrofloxacin respectively. The IC50 value of the assay established with the ScFv mutant was 1.63 ng/mL, while the parental ScFv was 21.08 ng/mL, this result showed highly increased affinity with up to 12.9-folds improved sensitivity. The mean recovery for ENR ranged from 71.80% to 117.35% with 10.46% relative standard deviation between the intra-assay and the inter-assay. The results indicate that we have obtained a highly sensitive anti-ENR scFv by the phage library construction and directional evolution, and the scFv-based IC-ELISA is suitable for the detection of ENR residue in animal derived edible tissues and milk.
Dynamic 18F-FDopa PET Imaging for Newly-diagnosed Gliomas: Is a Semi-quantitative Model Sufficient?
Authors: ZARAGORI Timothée , Doyen Matthieu , Rech Fabien , Blonski Marie , Taillandier Luc , Imbert Laetitia , Verger Antoine
Published: July 2021

Purpose: Even though the semi quantitative dynamic analysis of 18F-FDOPA PET effectively and non-invasively predicts isocitrate dehydrogenase (IDH) mutations in newly-diagnosed gliomas, the underlying kinetic model of 18F-FDOPA is complex. Our current study addresses whether a semi quantitative analysis indeed captures all the clinically relevant predictive features of the more sophisticated graphical and compartmental models.Methods: Thirty-seven tumour time-activity curves from 18F-FDOPA PET dynamic acquisitions of newly-diagnosed gliomas were analysed using a semi quantitative model with (Ref SQ) or without reference region (SQ), a graphical Logan model with input function (Logan) or reference region (Ref Logan), and a two-tissue compartmental model validated for 18F-FDOPA PET imaging in gliomas (2TCM). The overall predictive performance of each model for predicting IDH mutations was assessed, by an area under the curve (AUC) comparison of multivariate analyses of all parameters included in the model.Results: SQ model with an AUC of 0.733 showed comparable performances to other models with AUCs of 0.814, 0.693, 0.786, 0.863, respectively corresponding to Ref SQ, Logan, Ref Logan and 2 TCM (p≥0.11 for the pairwise comparisons with other models). SQ time-to-peak parameter had the best diagnostic performance relative to all individual parameters with an accuracy of 75.7%.Conclusions: The SQ model circumvents the complexities of the 18F-FDOPA kinetic model and yields similar performances compared to other models most notably the compartmental model for predicting IDH mutations. This validates the application of the SQ model for the dynamic analysis of 18F-FDOPA PET images in routine clinical practice for newly-diagnosed gliomas.
Uric Acid Promotes Diabetic Retinopathy Progression through Transforming Growth Factor β2(TGF-β2) Signaling and Beneficial Effects of Fenofibrate
Authors: Zhu Dandan , Mei Zhu , fang chi
Published: July 2021

Purpose: To elucidate the role of TGF-β2 and Fenofibrate in DR concomitant with HUA.Methods: In vitro, human retinal endothelial cells (HRECs) were incubated with high glucose(HG), HUA and HG mixed HUA respectively. The apoptosis rate was evaluated by TUNEL assay and Capase-3 activity. TGF-β2 and VEGF was detected by Western blot and real-time PCR. The therapeutic effect of Fenofibrate was revealed by detecting the level of peroxisome proliferator activated receptor a(PPARa) through Western blot and real-time PCR.Results: The level of cellular apoptosis, TGF-β and VEGF was conducted to increase most significantly in presence of HG mixed HUA stimulated HRECs. HG mixed HUA led to PPARa suppression which resulted in activated TGF-β2 expression, and this effect could be inhibited by Fenofibrate.Conclusion: TGF-β2 might be a pivotal mediator for the progression of DR with uric acid stress and Fenofibrate could be an important pathway to ameliorate diabetic complication.
Anterior lag screw position and suboptimal reduction in lateral plain as predictors of failure in cephalomedullary nailing of intertrochanteric fractures
Authors: Garabano German , Pereira Sebastian , Rodriguez Joaquin , Pesciallo Cesar Angel , Bidolegui Fernando
Published: July 2021

Background
Failed osteosynthesis of the proximal femur has a great impact on morbimortality, especially in elderly patients after hip fracture. The purpose of this study was to identify the variables associated with failure in intertrochanteric fractures treated with cephalomedullary nails.
Methods
We retrospectively analyzed 251 consecutive patients who underwent surgery between January 2016 and July 2019. Age, gender, fracture stability (AO/OTA), femoral neck angle (FNA), FNA difference with contralateral hip, lag screw position and tip-apex distance (TAD), union and failure rates were analyzed. Uni and multivariate logistic regression analyses were used to identify whether these variables were related to a risk of failure (cut-out, cut-through, and/or non-union).
Results
The failure rate was 9.56%: 7 non-union (2.78%), 10 cut-out (3.98%), and 7 cut-through cases (2.78%). Female sex (p = 0.018), FNA < 125° (p = 0.0036), FNA difference 7.5° with contralateral side in lateral view (p = < 0.0001), superior (p = 0.01413) - anterior (p = < 0.0001) lag screw position and TAD > 25mm (p = 0.0167) were identified as risk factors for these complications in univariate logistic regression. Female gender (OR 12.92–95CI 1.39–1736; p 0.0196), FNA difference in lateral view (OR 1.36–95CI 1.21–1.55; p < 0.001) and anterior screw position (OR 14.01 95CI 3.15–90.99; p < 0.001 ) were confirmed as independent predictors of failure in multivariate analysis.
Conclusion
This study confirmed female sex, malreduction in the lateral plane, and anterior screw position as independent predictors of failure. Every effort should be made to achieve an accurate reduction and proper implant positioning to improve failure rates.
Observed Evidences of Frequency-Dependent Site Spectral Amplification due to Strong Structural Control of Active Reverse Faults at Different Three Localities in Japan
Authors: Thabet Mostafa
Published: July 2021

In the present study, observed active fault zone related site amplification is calculated based on Fourier acceleration spectrum (FAS) at three different localities in Japan. For this purpose, the FASs are calculated using 26432 earthquakes recorded at 126 K-NET and KiK-net seismic stations, which are distributed on the fault zones and upthrown and downthrown sides. This observed amplification is strongly frequency-dependent because of the presence of the near-surface low-velocity flower fault structure and the deeper fault zone. Moreover, the amplification patterns at each study area are tectonic-specific patterns. Sources inside the active fault zones could produce amplification at high frequencies at stations on both fault zone and far away from the fault zone. This is because of the impact of the near-surface fault zone. Sources outside the active fault zones could not produce significant amplification at high frequencies, whereas remarkable high amplification at low frequencies exhibits a gradual increase through stations on hanging walls, fault zones, and footwalls. Remarkably, low-frequency amplification due to sources outside the active fault zones at stations on footwalls is much higher than those observed on hanging walls. Interestingly, the peaks of the low-frequency amplification are corresponding to wavelengths that approximately equalize the width of the fault zone. Diffuse field theory inversion using earthquake horizontal-to-vertical spectral ratio (EHVSR) could successfully detect the presence of fault zone low-velocity layers. However, analyzing the fault zone related site effects using HVSR is not effective because of the strong amplification related structural control of the active fault zones on the ground motions.
Re-Emergence of Syphilis in Women of Reproductive Age and its Association with the Increase in Congenital Syphilis, The Case of Mexico During the Years 2010-2019
Authors: García-Cisneros Santa , Herrera-Ortiz Antonia , Olamendi-Portugal Maria , Sanchez-Aleman Miguel A.
Published: July 2021

Background: Syphilis is a sexually transmitted infection that is re-emerging in different parts of the world. This infection can be transmitted during pregnancy causing neonatal syphilis. The objective of the study was to determine the trend of syphilis, congenital syphilis, and mortality from congenital syphilis among the Mexican population between the years 2010-2019. Methods. We formed databases about the incidence of syphilis, the incidence of congenital syphilis, cases of congenital syphilis, and deaths of congenital syphilis using information from the Morbidity and Mortality Yearbooks and the Bulletin of the Mexican Ministry of Health, considering age, sex, the states of Mexico, and year. The trend was analyzed using linear regression, the increase was estimated with 95% confidence intervals, and p<0.05 was considered statistically significant. Results. The incidence of syphilis increases on average 0.336 cases/100,000, being higher among women aged 15-19 years (0.693 cases). Congenital syphilis has grown, from 62 cases in the year 2010 to 372 cases in the year 2019; the cases of congenital syphilis have relation to the increase of syphilis among women aged 20-24 years. Fifty percent of the states of Mexico without cases of congenital syphilis in 2010, but only 10% in 2018. Between the years 2010 to 2017, 62 deaths from congenital syphilis were reported. Conclusion. Congenital syphilis is increasing in Mexico, as a consequence of the reemergence of syphilis among the population of reproductive age, it is necessary to attend to syphilis in various population groups.
Comprehensive Analysis of Clinical Prognosis and Molecular Characteristics of LTB4R2 in Clear Cell Renal Cell Carcinoma
Authors: Yuan Xia , Luo Chenhui , He Yi , Wang Wei
Published: July 2021

BackgroundClear cell renal cell carcinoma (ccRCC) is the most common renal cancer. LTB4 receptor 2 (LTB4R2, also called BLT2), as a chemokine receptor, has been reported to be upregulated in different tumors and associated with tumor cell proliferation and invasion. However, the correlation between BLT2 expression and its prognostic value in ccRCC remain to be explored.MethodsWe used the TCGA and GEO databases to evaluate the association between BLT2 expression and clinical outcome of ccRCC. The top 300 genes that most positively correlated with BLT2 were selected for functional enrichment analysis. Correlations between BLT2 expression and tumor immune characteristics in ccRCC were evaluated based on TIMER2.0.ResultsBLT2 expression was higher in ccRCC than normal tissues. Kaplan-Meier survival analysis indicated that high BLT2 expression was significantly correlated with poor overall survival (HR = 1.75, p＜0.001) and disease-speciﬁc survival (HR = 1.60, p＝0.014) for patients with ccRCC. In addition, the findings revealed that M1 marker genes had no significant correlations with BLT2 expression in ccRCC, while moderate correlations were observed between BLT2 expression and M2 marker genes. The marker genes of Tregs and T cell exhaustion positively correlated with BLT2 expression in ccRCC (p＜0.001). ConclusionBLT2 may serve as a novel prognostic biomarker and correlate with tumor immune microenvironment shaping in ccRCC. BLT2 expression potentially contributes to the regulation of TAMs, T cell exhaustion, and Tregs activation in ccRCC, providing new approaches to drive the development of new immunotherapeutic strategies for ccRCC.
Adalimumab in Vogt-Koyanagi-Harada Disease Refractory To Conventional Therapy
Authors: Yang Shizhao , Huang Zhaohao , Liu Xiuxing , Li He , Xie Lihui , Su Wenru
Published: July 2021

Purpose
To evaluate the short-term effectiveness and safety of adalimumab (ADA) in patients with sight-threatening Vogt-Koyanagi-Harada (VKH) disease refractory to conventional therapy.
Methods
Medical records of VKH patients who had been treated with systemic glucocorticoids and immunosuppressants but whose condition was poorly controlled were collected and analyzed. Primary outcomes comprised of best-corrected visual acuity (BCVA), intraocular inflammation, relapses, and glucocorticoid-sparing effects. Other outcomes included central macular thickness (CMT), intraocular manifestations and adverse events (AEs).
Results
Nine refractory VKH patients with a median age of 30 (16, 43) years old were enrolled in this study and received treatment for a median of 10 (7, 11) months. Mean BCVA improved from 0.36 ± 0.26 at baseline to 0.41 ± 0.28 at final visit (P = 0.266). The anterior chamber cell grade decreased from 2 (1.75, 3) + at baseline to 0.5 (0, 1.25) + cell at final visit (P < 0.001). The vitritis grade decreased from 1 (1, 1) + cell at baseline to 0 (0, 1) + cell at final visit (P < 0.001). Patients suffered a median of 1 (0, 2) relapse during treatment. CMT remained stable from 238.50 ± 144.94 µm at baseline to 219.28 ± 77.20 µm at final visit (P = 0.553). The mean prednisone dosage decreased from 21.91 ± 18.39 mg/d to 2.73 ± 4.10 mg/d (P = 0.005). No severe AEs were found during treatment.
Conclusions
The outcomes indicated that ADA was an effective and safe option for VKH patients refractory to conventional therapy by controlling inflammation, preserving visual function and reducing the daily glucocorticoid dose.
Design, Synthesis and Biological Evaluation of HDAC and VEGFR Dual Inhibitors as a Multi-targeted Anticancer Agents
Authors: Xue Xia , Zhang Yingjie , Liao Yongxiang , Sun Deqing , Li Lina , Liu Ying , Wang Yongjie , Jiang Wen , Zhang Jian , Luan Yun , Zhao Xiaogang
Published: July 2021

Herein a novel series of HDAC and VEGFR dual inhibitors were designed, synthesized and biologically evaluated based on the previously reported pazopanib-based HDAC and VEGFR dual inhibitors. Most target compounds showed significant HDAC1, HDAC6 and VEGFR2 inhibition, which contributed their potent antiproliferative activities against multiple cancer cells lines and significant antiangiogenic potencies in both HUVECs tube formation assay and rat thoracic aorta rings assay. Further HDAC selectivity evaluation indicated that hydroxamic acids 5 and 9e possessed similar HDAC isoform selectivity profiles to the approved HDAC inhibitor SAHA, while hydrazide 12 presented similar HDAC isoform selectivity profiles to the clinical HDAC inhibitor MS275. The VEGFR inhibition profiles of 5, 9e and 12 were similar to that of the approved VEGFR inhibitor pazopanib. The intracellular target engagements of compounds 5 and 12 were confirmed by western blot analysis. Though the mouse liver microsome metabolic stabilities of 5, 9e and 12 were inferior to than of pazopanib, these HDAC and VEGFR dual inhibitors provided lead compounds for further structural optimization to get polypharmacological anticancer agents.
In vivo Assessment of APPJ Discharge on the Earthworm: Coelomic TAC and MDA Levels, Cell Death and Tissue Regeneration
Authors: Gholami Neda , Colagar Abasalt Hosseinzadeh , Sinkakarimi Mohammad Hossein , Sohbatzadeh Farshad
Published: July 2021

The cold atmospheric pressure plasma jet (APPJ) is one of the effective tools with medical applications that its positive effects have been reported by various researchers, including sterilization of liquid and solid surfaces, treatment of chronic wounds, treatment of cancer tumors, and blood clots. This study investigated the effects of APPJ discharge on the two species of Earthworms (Aporrectodea trapezoides and Eisenia fetida). The APPJ discharge for different time durations, zero as a blank, 5, 10, 20, and 30 seconds, on these two species. Then some of these effects on the worms, including regeneration ability to miss segments, Malondialdehyde (MDA), catalase activity (CAT), total antioxidant capacity (TAC), cell death, total proteins, and protein profile in the coelomic fluid were investigated. Results showed levels of TAC and CAT increased after plasma treatment. In addition, a significant change was not observed in MDA levels and cell death. In summary, it can be concluded that APPJ exposure up to 40 seconds didn’t inhibit effects on the TAC levels of the earthworms and the defense system was able to fight oxidative stress and by increasing the expression of some proteins APPJ lead to better regeneration.