bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Peran Pengusaha dalam Mengurangi Pengangguran Terbuka Perspektif Ekonomi Islam di Kota Bima (Studi Kasus HIPMI dan TDA Kota Bima)
Authors: Ismail Ismail , Wa’adarrahmah Wa’adarrahmah
Published: February 2022

Penelitian ini bermaksud menganalisis peran pengusaha dalam mengurangi pengangguran terbuka perspektif Ekonomi Islam serta kendalanya. di Kota Bima yang bertujuan untuk mengetahui sejauh mana peran serta. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif. Sedangkan teknik pengumpulan data yaitu observasi, wawancara dan dokumentasi. Jenis data penelitian yaitu data primer dan data sekunder. Kemudian data-data yang terkumpul dianalisis dan selanjutnya dilakukan uji keabsahan data dengan cara tringulasi data. Hasil penelitian ini menunjukkan bahwa peran pengusaha dalam mengurangi pengangguran terbuka di Kota Bima memiliki kontribusi real, dan perannya telah mengadopsi semangat Ekonomi Islam. Hal ini dapat dilihat dari pengusaha yang tergabung dalam HIPMI dan TDA memiliki bisnis yang berisiko dan cukup sukses dan mampu merekrut karyawan yang banyak seperti Yuank Cafe, Hotel La Ila, dan Fix La Luna, sehingga itu sedikit tidaknya mampu mengurangi angka pengangguran di Kota Bima. Sedangkan untuk kendalanya yaitu kurangnya penyuluhan tentang kedua organisasi tersebut, masyarakat berorintasi PNS, dan kurangnya jiwa wirausaha dalam diri masyarakat.
Analisis Strategi Relationship Marketing pada BMT NU Pragaan Kabupaten Sumenep
Authors: Tarmidzi Anas Achmad , Ismail Ismail
Published: February 2022

Penelitian ini bertujuan untuk (1) menganalisis strategi relationship marketing pada BMT NU Pragaan Kabupaten Sumenep, (2) menganalisis implikasi relationship marketing pada BMT NU Pragaan Sumenep. Penelitian dilakukan menggunakan pendekatan kualitatif, dengan jenis peneltian studi kasus. Teknik pengumpulan data yang dilakukan dengan menggunakan metode observasi, wawancara dan dokumentasi. Sedangkan pengecekan keabsahan data menggunakan trianggulasi teknik. Hasil penelitian menunjukkan bahwa strategi yang dibangun adalah: Pertama, menyediakan berbagai jenis produk secara kompleks. Kedua, menjalin silaturahmi dengan mengadakan pertemuan rutin di daerah-daerah prioraitas yang memiliki prospek besar dalam menjalankan pemasaran. Ketiga, mempererat hubungan serta menjalin kerjasama dengan beberapa instansi atau lembaga tertentu pada beberapa kegiatan tertentu untuk tetap menjaga hubungan dengan nasabah. Keempat, memberikan pelayanan jemput bola untuk memudahkan nasabah dalam melakukan transaksi. Kelima, menghadiri beberapa kegiatan lembaga pendidikan untuk menjaga hubungan kekeluargaan serta menjaga ikatan emosional dengan nasabah. Adapun implikasinya, mampu menarik minat nasabah untuk melakukan transaksi serta meningkatkan loyalitas nasabah lama terhadap BMT NU karena terbentuknya kepercayaan serta rasa nyaman dengan hubungan yang dibangun. Sehingga strategi relationship yang dibangun oleh BMT NU mampu meningkatkan citra positif terhadap masayarakat.
Discusiones sobre igualdad y equidad en educación : un análisis del sistema educativo de Bogotá
Authors: Andrés Hortúa Clavijo,
Published: February 2022

La presente tesis doctoral, se enmarca en la discusión acerca de la igualdad y la equidad y sus posibilidades de llevarse a cabo a través de la educación. En un principio, se presentan los referentes teóricos que en conjunto se agrupan bajo la dimensión genérica de justicia social la cual en particular discurre por igualdad, equidad, desarrollo, distribución, reconocimiento, participación, diferencia y diversidad entre otros. En un segundo momento, se toma un estudio de caso, con el fin de analizar los alcances de la política social y educativa en una ciudad particular como Bogotá, la cual ha realizado esfuerzos ingentes en las últimas tres décadas para el mejoramiento de la educación. Hablar de igualdad y equidad en el caso de las poblaciones que conforman un territorio (Estado, Nación, República) se convierte en un asunto difícil en cuanto la frontera entre una y otra es ambigua, no siempre se puede demarcar cuando es necesaria la una o la otra y cuando un sujeto o grupo social requiere de la una, de la otra o de ambas; sin embargo, es fundamental dejar claro, que las anteriores problematizaciones solo son posibles porque se ha entrado de lleno en la discusión y en la actualidad se pueden hacer distinciones producto tanto de la experiencia lograda, los desarrollos sociales y los avances teóricos.
对经济合作组织的实际有效汇率、国际收支 与经济增长的区域经济一体化验证
Authors: 江 雅轩 , 周 祎宁
Published: February 2022

在经济全球化的背景下，世界各国的经济往来与联系变的日益密切，全球经济与世界市场日益一体化，国际经济一体化可以分为多边一体化和区域一体化。一国的国际收支会对其利率、汇率、贸易、财政、外汇管理和对外投资等方面产生重要的影响，国际收支平衡也成为分析区域经济情况的重要指标，从而更好地制定相应的经济政策。本文在多元回归模型基础上，对四个不同地区的经济同盟进行模型分析，同时采用平稳性检验、格兰杰因果关系检验和协整检验，通过脉冲响应分析研究变量间的相互作用。实证分析表明，对亚太经济合作组织来说，投资、物价、所得和进口对国际收支平衡调节的影响较大，在国际收支平衡的调节中可以发挥一定的作用；对南亚区域合作联盟来说，投资和汇率的影响较大，在国际收支平衡的调节中可以发挥一定的作用；对于中西亚经济合作组织和海湾合作委员会而言，则无法确定哪一个效应对国际收支平衡调节的影响最大。组织成员国数量多，国家之间差异性大很难统一，造成因素间影响复杂化；为了达到共同发展，合作共赢，各组织内部应该加强合作，组织间应该互相学习，找到最适合的发展方法和模式。
MAIN RESULTS OF COMPLEX RESEARC INTO THE TSKALTUBO CAVE SYSTEM
Authors: Jishkariani Jumber , Tatashidze Zurab , Tsikarishvili Kukuri , Lanchava Omar
Published: February 2022

The paper presents the results of complex research carried out for years into the Tskaltubo cave system. Main features of aeroionization, morphological, climatic, hydrological, and radiological characteristics of the cave system have been analyzed. Complex research results served as a basis for equipping the cave for speleotourism purposes. © 2010 Bull Georg. Natl. Acad. Sci.
TOWARDS DETERMINING THE DIMENSIONLESS TEMPERATURE OF THE WALLS OF UNDERGROUND WORKING
Authors: Lanchava Omar
Published: February 2022

Mathematical modelling of heat exchange was carried out in the system: thermal waters-rocks-mine air with a view to determining the dimensionless temperature of the walls of underground working with thermal waters. The following formula is proposed as a result. where are empirical coefficients the values of which are given in the paper; F0 is the Fourier number; Bi the criteria of the Biot boundary conditions.
SEPARATION AND EVALUATION OF SIMULTANEOUS HEAT-MASS EXCHANGE IN BINARY SYSTEMS
Authors: Lanchava Omar
Published: February 2022

A new criterion for separation and evaluation of simultaneous heat and mass exchange process obtained on the basis of tertiary boundary condition analysis is introduced using я-theory and L’Hospital’s rule. The numerical value of the criterion shows whether consideration of additional heat flow during simultaneous heat-mass exchange is necessary or not. © 2005 Bull. Georg. Acad. Sci.
Efek Asam Askorbat Menurunkan Indeks Aterogenik dan Kadar Gula Darah Tikus (Rattus norvegicus L.) Diabetes Mellitus Induksi Aloksan
Authors: Sunarti Sunarti , Wahyudin Elly , Kasim Hasyim
Published: February 2022

Senyawa antioksidan diketahui dapat meningkatkan indeks aterosklerosis dan sekresi insulin. Penelitian ini bertujuan untuk mengetahui peran asam askorbat sebagai pengatur aterosklerosis dan kadar gula darah pada kondisi diabetes  (DM). Rancangan penelitian yang digunakan adalah penelitian  eksperimental dengan menggunakan 20 ekor tikus putih jantan (Rattus norvegicus L.) dengan berat badan 180-300 g, umur 23 bulan, sebagai hewan percobaan. Setelah aklimatisasi selama satu minggu, tikus tidak diberi makan semalaman dan keesokan harinya diinduksi aloksan dengan dosis 145 mg/kg berat badan (BB). Tiga hari kemudian, darah diambil melalui vena ekor tikus untuk menguji gula darah. Indeks arteriosklerosis (AI) ditentukan dengan rumus (kolesterol HDL total)/HDL. Sebagai hewan percobaan, tikus dengan kadar glukosa darah 200 mg/dl atau lebih dipilih dan dibagi menjadi 4 kelompok yang masing-masing terdiri dari 5 ekor tikus. kelompok I pakan standar; Kelompok II mendapat diet standar majemuk dan metformin; Kelompok III diberi diet standar dan asam askorbat dan kelompok IV diberi diet standar dan kombinasi metformin dan asam askorbat. Pada awal diabetes, berat  tikus dikurangi dari 240 g menjadi 220 g. Namun, setelah 2 minggu terapi asam askorbat, berat badan stabil, gula darah turun 65,57 dan 324,94 mg/dl menjadi 111,88 mg/dl, dan indeks arteriosklerosis menurun dari 0,324 menjadi 0,320.
Kajian Etnofarmakologi Tumbuhan Obat Untuk Penyakit Hipertensi Di Kelurahan Bontonompo Kecamatan Bontonompo Kabupaten Gowa
Authors: Base Nurul Hidayah , Yusriyani Yusriyani , Hardianti Siti
Published: February 2022

Tumbuhan obat merupakan seluruh spesies tumbuhan yang diketahui atau dipercaya mempunyai khasiat sebagai obat. Tumbuhan obat tersebut dikelompokkan menjadi tiga yaitu tumbuhan obat tradisional, tumbuhan obat modern, dan tumbuhan obat potensial. Kajian etnofarmakologi tumbuhan obat dalam pengobatan penyakit hipertensi dilakukan untuk mengkaji informasi tentang pemanfaatan tumbuhan obat meliputi nama tumbuhan, bagian Tumbuhan yang digunakan, cara pengolahan dan penggunaannya berdasarkan kebiasaan masyarakat di kelurahan Bontonompo Kecamatan Bontonompo Kabupaten Gowa. Penelitian dilakukan dengan metode Snowball sampling dengan menggunakan teknik observasi, wawancara, dan dokumentasi.  Informasi yang diperoleh selanjutnya dikaji dengan metode literasi untuk mendapatkan informasi ilmiah dari hasil penelitian maupun dari rujukan buku dan peraturan yang ditetapkan oleh pemerintah. Hasil penelitian menunjukkan bahwa terdapat 13 jenis tumbuhan obat yang digunakan dalam pengobatan penyakit hipertensi yang terdiri dari 46,15% daun, 38,64% buah, 7,69% akar, dan 7,69% umbi.  Rata-rata tumbuhan obat diolah dengan cara direbus menggunakan air mendidih kemudian dikonsumsi dengan cara diminum dan 84,6% merasakan gejala penyakit berkurang setelah penggunaan tumbuhan obat secara rutin.
Pemberian Injeksi Antibiotik Pada Pasien di Ruang Perawatan Penyakit Dalam di Rumah Sakit Palembang
Authors: Siregar Estelita O.N. , Simamora Sarmalina , Mangunsong Sonlimar
Published: February 2022

Penggunaan antibiotic (AB) haruslah sesuai dengan kebutuhan klinis. Penggunaan tidak tepat memberikan berbagai dampak negatif antara lain timbulnya efek samping, mempercepat terjadinya resistensi, terjadi resiko kegagalan terapi, bertambah beban penyakit pasien, lamanya pasien menderita, serta meningkatkan biaya pengobatan. Tujuan penelitian ini adalah menganalisa ketepatan pemberian antibiotik injeksi di ruang rawat inap. Jenis Penelitian adalah observasional dengan pendekatan deskriptif. Populasi dari penelitian ini adalah semua pasien dirawat inap Rumah Sakit yang diberikan antibiotik pada bulan Januari-April 2019 yang berjumlah 176 dilihat pada kartu rekam medik. Tepatnya waktu penyuntikan injeksi antibiotik dilihat dari kesesuaian catatan rekam medik dengan paraf petugas perawat SD(±30 menit) dari setiap pemberian pertama. Frekuensi umur 46-65 yang paling banyak diberikan antibiotic. Frekuensi berat badan yang < 70 kg paling banyak menggunakan antibiotik injeksi sesuai dosis. Pemberian dosis AB dengan Berat badan >70 kg belum tampak penyesuaian dosis. Pada riwayat alergi hanya 1 pasien ditemukan alergi terhadap antibiotik dari total sampel. Kesimpulan ketepatan waktu pemberian antibiotik injeksi dinyatakan 80% tepat waktu penyuntikan antibiotik injeksi sedangkan 20% tidak tepat. Sebanyak 20% belum patuh dalam penulisan rekam medik.
Hubungan Pola Makan dengan Kejadian Gastritis pada Santri
Authors: Premesti Widowati Galuh , Riyadi Muskhab Eko
Published: February 2022

Ada beberapa faktor penyebab terjadinya gastritis di Indonesia salah satunya adalah pola makan. Pola makan yang salah dapat menyebabkan infeksi pada lambung. Santry memiliki pola makan yang tidak teratur dan sering mengonsumsi makanan yang menyebabkan sakit perut. Tujuan penelitian ini adalah untuk mengetahui hubungan antara pola makan dengan kejadian gastritis pada santri  Pondok Pesantren Al Itishom Gunungkidul, DI. Yogyakarta. Penelitian ini merupakan penelitian non-eksperimental dengan desain penelitian potong lintang yang melibatkan 159 santri  Pondok Pesantren Al-Itishom Gunungkidul DI. Yogyakarta dengan besar sampel 61 responden. Pengambilan sampel berurutan digunakan untuk metode pengambilan sampel, dan uji chi-kuadrat digunakan untuk pengujian statistik. Hasil penelitian ini menunjukkan bahwa  pola makan santri yang paling banyak adalah Pondok Pesantren Al Itishom Gunungkidul DI. Hasil uji statistik diperoleh nilai probabilitas (p) sebesar 0,000 (p<0,05) dan nilai koefisien korelasi (r) sama ~0,502, dimana Diet dan tekanan sedang menunjukkan adanya hubungan antara  kejadian gastritis
Seroprevalence of Dengue by Detection of NS1, IgM in Tertiary Care Hospital, RIMS, Ranchi
Authors: Topno Vidushi , Kumar Manoj , Sharma Ashok Kumar
Published: February 2022

Introduction: Dengue virus being most significant among vector borne diseases is leading to increased morbidity and mortality in India. Global prevalence of dengue has been increasing over the last decade. So, it is important to screen all dengue fever like cases.
Objective: The study was conducted to know seroprevalence of Dengue virus by detecting NS1, IgM in clinically suspected dengue fever cases.
Material and Method: Test was done in 315 blood samples of clinically suspected dengue fever cases, in various departments of RIMS, Ranchi. The study was done from November 2016 to August 2017. NS1 antigen and IgM antibody detection both were done by ELISA (NS1 by Qualisa Microwell Enzyme Immunoassay and IgM by NIV Dengue IgM Captured ELISA KIT).
Result and Discussion: Out of 315 blood samples, 84 samples (26.7%) were serologically positive for dengue infection. Among the positive cases 72.6% were males and 27.4% were females. Males are more affected than females, because males are more exposed during their outdoor visit for livelihood. Age group between 21-30 years were most affected. Most of the cases were reported in monsoon and post- monsoon season.
Conclusion: This study highlights the need of continuous surveillance by both NS1 antigen and IgM antibody by ELISA method for early detection of impending outbreak to initiate timely prevention and control measures.

Keywords: Dengue, NS1, IgM.
The Effect of Omnichannel Strategy on Customer Loyalty through Customer Experience in KCA (Kredit Cepat Aman) Product at PT. Pegadaian (Persero) Labuhan Deli Sub-Branch
Authors: br Sinurat Mariana Angelia , Rini Endang Sulistya , Wibowo Rulianda Purnomo
Published: February 2022

The Industry 4.0 era is an era of innovation and prioritizing technology and digitization in carrying out daily activities. This study aims to determine how much influence the omnichannel strategy has on customer loyalty through customer experience in the KCA (KREDIT CEPAT AMAN); Fast Secured Credit product of PT Pegadaian (Persero) Labuhan Deli Sub-Branch. This research is descriptive type research with a quantitative approach. The research sample consisted of 215 KCA customers of PT Pegadaian (Persero) Labuhan Deli Sub-Branch who had made KCA pawns using at least 2 channels. Based on the formulated hypothesis, the entire data analysis was processed using SEM - PLS analysis techniques using SmartPLS 3.0 software. Based on the results of the test, it was found that the exogenous variable (omnichannel strategy) had a positive and significant effect on the endogenous variable (customer loyalty) and the mediating variable (customer experience), the mediating variable (customer experience) had a positive and significant effect on the endogenous variable (customer loyalty). Based on the r-squared value, the exogenous variable (omnichannel strategy) was able to influence the mediating variable (customer experience) by 85.8% and the exogenous variable (omnichannel strategy) was able to influence the endogenous variable (customer loyalty) by 47.7%.

Keywords: Omnichannel strategy, Customer Loyalty, Customer Experience.
Singing Activity for Mentally Disabled Children of St. Lusia Extraordinary School C in Deli Serdang Regency
Authors: Panggabean Ance Juliet , Galingging Kamaluddin
Published: February 2022

Mentally retarded children generally have problems in communication, interaction, and empathy. Children with mental retardation also look different physically, mentally and socially emotionally. Children with developmental delays physically, mentally, cognitively, the handling of these mentally retarded children requires a very special approach. The obstacles experienced by mentally retarded children make it difficult for them to do both homework, especially jobs that require expertise. But despite having obstacles they still have the ability to do simple jobs. To develop the abilities possessed by mentally retarded children, training and assistance are needed. With this training and assistance, it is hoped that mentally retarded children will have the ability to work. The training and mentoring are given specifically, step by step until the child is really able to master one job. Every child has different abilities, so a very adequate and varied training advice is needed. Research with the process of singing activities was carried out with several methods applied in data collection, namely: (1) observation method, (2) library method, (3) qualitative descriptive method. The singing activity was considered quite successful. Success indicators can be seen and evaluated through children's daily activity units which are recorded as a reference to determine the development and progress of children in each activity carried out.

Keywords: Singing activity, mentally disabled children, extra-ordinary school.
Optimization of Cr Seed Layer Effect for Surface Roughness of As-Deposited Silver Film using Electron Beam Deposition Method
Authors: Naseem Abbas Naseem Abbas , Muzamil Hussain Muzamil Hussain , Nida Zahra Nida Zahra , Hassaan Ahmad Hassaan Ahmad , Syed Muhammad Zain Mehdi Syed Muhammad Zain Mehdi , Uzair Sajjad and Mohammed Amer Uzair Sajjad and Mohammed Amer
Published: February 2022

The surface roughness is an important parameter in determining the physical properties and quality of thin films deposited by physical vapor deposition (PVD) method. The presence of an intermediate layer between metallic nanoparticles and substrate significantly promotes the adhesion and reduces the surface roughness. In this article, we have investigated the effect of Chromium (Cr) seed layer to optimize the surface roughness on the growth of as-deposited silver (Ag) film using borosilicate glass and silicon wafer substrates. For this purpose, Ag thin films were deposited with a Cr seed layer of different thickness on borosilicate glass and silicon wafer substrates using an electron beam (E-Beam) deposition method. The Cr thin film of different thickness ranging from 1 nm to 6 nm was thermally evaporated and pure Ag with the same thickness was evaporated at the same rate on previously coated substrates. The deposition of the nanostructured thin film was confirmed by UV-Vis and XRD characterizations. The difference in transmittance for uncoated and coated substrates ensured the deposition. The presence of pure Ag crystalline phase was confirmed by XRD pattern. Surface roughness was measured using Atomic Force Microscopy (AFM) and the conductance was measured using 4-probe conductivity method. The density of nanoparticles and smoothness were visualized from two dimensional (2D) and three dimensional (3D) surface height histograms of representative AFM images. The quantitative roughness was measured in terms of root mean square (RMS) roughness and mean roughness. The high dense and smoother thin films were found for ~2-4 nm Cr layer thickness in case of the glass substrate. The slight increase in roughness was observed for ~1-6 nm Cr layer thickness in case of the silicon substrate. The dependence of the conductivity of thin films on surface roughness is investigated to verify the effect of surface roughness on different applications of Ag thin film. The conductance results have been analyzed as; for a glass substrate, conductivity was maximum for thin films containing ~2 nm Cr seed layer thickness, while for silicon substrate the maximum conductivity was found for the thin film containing ~1 nm Cr seed layer.
Investigation of Creep Behavior of CNT Reinforced Ti6Al4V Under Dynamic Loads
Authors: Ismail Topcu Ismail Topcu , Burcu Nilg n etiner Burcu Nilg n etiner , Arif N G ll o lu and zkan G lsoy Arif N G ll o lu and zkan G lsoy
Published: February 2022

This study investigates the effects of addition of Carbon nanotube (CNT) at different volume ratios (0.5- 5%) into Ti6Al4V matrix by mechanical alloying in terms of the density, microstructure, hardness and creep under dynamic load. As a result of the good bonding of carbon nanotubes powders with the main matrix, Ti-6Al-4V/CNT composites have experienced change both in microstructure and mechanical properties (such as hardness, density) and, correspondingly, qualitatively creep behaviour of Ti-6Al - 4V matrix alloy has been improved compared to the lean one. The density of CNT reinforced Ti6Al4V composites sintered at 1300and#176;C for 3h decreases with increasing CNT content. The hardness tests indicated that the hardness of composites increased with CNT addition. In addition, although creep strain is decreased continually with CNT content until 5%, creep life increased with increasing CNT content until 4% of CNT but decreased above 4%. After sintering at 1300 and#176;C under vacuum for 3 hours the density of the composite material reached to a level of 98.5 %, the microhardness to 538 HV and the creep behaviour was improved. The characterization of Ti6Al4V / CNT composites after mechanical alloying was carried out using scanning electron microscopy (SEM), energy dispersive x-rays spectroscopy (EDS) analysis and X-ray diffraction (XRD) methods.

Although Ti–6Al–4V alloys are used as biomaterial, this study aimed at using MWCNTs containing Ti-6Al-4V composites at high temperature applications. Because MWCNTs reinforced Ti-6Al-4V composites are cheaper and have lower weight than the other materials used in this kind of applications.
Analysis of Functional Components of Burdock (Arctium lappa root) Standard Water Extract and its Aphrodisiac Effect in Experimental Rats
Authors: Guo qing Ren Guo qing Ren , Xiao ning Luan and De qiang Dou Xiao ning Luan and De qiang Dou
Published: February 2022

High performance liquid chromatography (HPLC) analysis showed that the content of chlorogenic acid in burdock standard water extract (BSWE) was about 1.22and#177;0.07 mg/g and no araciin and arctigenin was detected. The inulin was determined to be 174.33and#177;3.68 mg/g in BSWE by colorimetry method. The amino acids were analyzed by the amino acid analyzer and showed that asparagine and arginine are higher and determined to be 3021.00and#177;13.53mg/100g, 2042.33and#177;8.62mg/100g in BSWE, respectively. The results of aphrodisiac pharmacological experiments showed that the number of riding, insertions and the latency of rats in BSWE groups showed significant differences as compared with control, at the 7th day and 15th day after drug administration. Further study indicated that the aphrodisiac effect of BSWE is mostly associated with its regulation on NO, sialic acid and antioxidative ways and arginine should be one of the active components in BSWE.
Efficient Construction of 4-hydroxy-4-arylbutan-2-ones through an Enantioselective Aldol Reaction Mediated by a Recoverable Proline-Based Chiral Ionic Liquid
Authors: Dao Cai Wang Dao Cai Wang , Cong Wu Cong Wu , Chi Zhang Chi Zhang , Fang Zhen Zhou Fang Zhen Zhou , Hang Song and Xiao Peng Liu Hang Song and Xiao Peng Liu
Published: February 2022

Chiral ionic liquid derived from L-proline worked as an excellent organocatalyst for the enantioselective aldol reaction of aromatic aldehydes and acetone. The reaction was conducted in the presence of [BMIM][BF4] as reaction medium. The substrate scope of aldol reaction was successfully explored for various aromatic aldehydes under the mild conditions. The generated aldol products were separated by column chromatography with moderate to good yields as well as enantioselectivities. The main advantage of this catalytic method was that the catalyst and solvent could be recovered at the same time and reused for at least five times with satisfactory performance.
Rapid and Sensitive Bioanalytical Method Development and Validation for Quantification of Metoprolol Using LC-MS/MS in Human Plasma
Authors: Beludari Mohammed Ishaq Beludari Mohammed Ishaq , Lingareddygari Siva Sanker Reddy Lingareddygari Siva Sanker Reddy , Gajula Mahaboob Basha Gajula Mahaboob Basha , Munna Sreenivasulu Munna Sreenivasulu , Challa Madhusudhana Chetty and Hindustan Abdul Ahad Challa Madhusudhana Chetty and Hindustan Abdul Ahad
Published: February 2022

A novel, accurate, simple and selective LC-MS/MS method was developed and validated for the determination of metoprolol in human plasma. Due to structural resemblance Propranolol was selected as internal standard. Anti coagulant used was K2 EDTA. Metoprolol, used in the therapy and management of hypertension, myocardial infraction and other cardio vascular diseases. Liquid – liquid extraction technique with tert-butyl methyl ether was applied for the extraction of analyte from human plasma. Kromasil C18 column (5and#181;, 100 and#215; 4.6 mm) with an isocratic mobile phase of 5mM Ammonium Formate pH 3.5 and Acetonitrile (15:85 % V/V) was used for the resolution. Sample ionization was done with Electrospray ionization technique in positive ion mode. Selectivity was enhanced by tandem mass spectrometric analysis via two multiple reaction monitoring (MRM) transitions, m/z 268.15→115.90 for metoprolol and 260.17→115.90 for Propranolol respectively. The linearity of the method was established over a concentration range of 1.505 – 538.254 ng/mL, in human plasma, with the precision and accuracy ranging from 4.67 to 7.41% and 90.66 to 98.15% respectively. The stability of the analyte was evaluated in plasma under different storage conditions.
Design and Synthesis of 7-Azaindole Derivatives and Their Antitumor and Analgesic Activities
Authors: Xue Kun Liu Xue Kun Liu , Yan Qiu Wang Yan Qiu Wang , Tong Jian Zhao Tong Jian Zhao , Yuan Hua Lu Yuan Hua Lu , Jia Nan Zhao Jia Nan Zhao , Xiao Yu Geng Xiao Yu Geng , Jie Ma Jie Ma
Published: February 2022

To develop effective anti-tumor and analgesic drugs, a series of novel 7-azaindole derivatives were designed and synthesized through a four-step reaction. 18 target compounds were obtained and characterized through Nuclear Magnetic Resonance and High Resolution Mass Spectrometry. Their anti-proliferative activities and analgesic effect were evaluated. When the 1-position was a methylsulfonyl group and the 5-position was a nitro group, compound 4f demonstrated the best activity. Furthermore, there was a dramatic difference between the IC50 values of compound 4f in tumor and in healthy cell line. The IC50 values of compound 4f in MCF7 breast cancer cell line was 5.781 μmol/L and 8.077 μmol/L in HepG2 hepatoma carcinoma cell line, but more than 100 μmol/L in HL7702 liver cell line. Preliminary results showed that compounds 3a, 3g and 4i had significant analgesic effects in mice, which were stronger than aspirin. These compounds have good prospects for new drug development.
Transformation of Bromhexine, a Mucolytic Drug into Potential Pharmacologically Important Urea Derivatives
Authors: Muhammad Sharif Muhammad Sharif
Published: February 2022

A general synthesis for 1,3-diphenylurea and 1,3-diphenylthiourea derivatives of mucolytic agent bromhexine is described by reactions of different commercially available phenyl isocyanates and phenyl-isothiocyanates at room temperature without any additional catalyst and additive. Using commercially available electron donating and electron withdrawing phenyl isocyanates in the transformation of bromhexine into urea derivatives proceeded from moderate to high product yield (42-90%). Bromhexine resulting compounds add a general interest in the fields of Pharmaceuticals, diagnostics and materials.
Impact of Anionic Dopant Precursor on Nanostructured ZnO thin Films Surface Morphologies
Authors: Arshid Mahmood Ali Arshid Mahmood Ali , Aishah Mahpudz Aishah Mahpudz , Usman Saeed Usman Saeed , Sami U Rather Sami U Rather , Ayyaz M Nawaz Javaid A and Hui Zhang Ayyaz M Nawaz Javaid A and Hui Zhang
Published: February 2022

The aim of this study is to investigate the impact of an anionic precursor [N2 gas and triethyleneamine (TEA) as nitrogen dopant source] to prepare anionic doped ZnO thin films surface morphologies, via a novel route - hydrothermal solution deposition at low temperature. The effect of dopant concentration under both with and without pH control was studied. The less populated doped ZnO crystal nearly had the same band gap as compared to undoped ZnO thin films. The photocatalytic activity of selected doped ZnO thin films were studied for the degrdation of 10 mg L-1 Methylene Blue under UV irradiation of 254nm. Based on the 1st order reaction rate constant results the morphology N2:S2-MS has shown highest degradation followed by N:S1-MS. Overall, the photocatalytic activity order is N2:S2-MS andgt; N:S1-MS andgt; N:S2-CG andgt; N:S1-CG. In general, a significant variation in surface morphologies, crystal size and population, porosity and orientation were observed. This tailored-made variation enabled the doped ZnO thin films to successfully degrade the waste methylene blue effluents.
Removal of Acid Textile Dye from the Aqueous Solution by a New Adsorbent Obtained from Waste Cotton from the Garment Plant
Authors: Aleksandra Micic Aleksandra Micic , Dragan Djordjevic Dragan Djordjevic , Ivona Jankovic Castvan Ivona Jankovic Castvan , Nenad Cirkovic Nenad Cirkovic , Bratislav Todorovic Bratislav Todorovic
Published: February 2022

The paper investigates the possibility of removing acid dye from the aqueous solution by an adsorption process on new adsorbent prepared from waste cotton textile from the ready-made garment industry. It is a waste generated during the cutting of the layers of cotton knitwear, which is practically the product from the textile cutting process. The obtained adsorbent is a bulk material with heterogeneous porous particles, of ragged shapes. In particle interiors, there are pronounced cracks, cavities and channels that form the basis of microporous material. The qualitative and quantitative characterization of the obtained adsorbent shows that this is a relatively porous material where the carbon is dominant in the chemical composition. The results of textural properties of new adsorbent from cotton knitwear waste show different parameters which with their numerous values characterize the specific surface area, pore volume or pore diameter. It can be said that the obtained new adsorbent has micropores and small mesopores, which produce a high specific surface area. During adsorption, the longer contact time causes a greater amount of dye on the adsorbent, i.e. with the duration of the adsorption process the dye concentration in the solution decreases. A number of isotherms of two- (Langmuir, Freundlich and Jovanovic), three- (Toth, Sips and Radke-Prausnitz), and four-parameter models (Fritz-Schlunder and Marczewski-Jaroniec) were used to describe the adsorption process. The four-parameter isotherms are best covered by experimental points and most accurately describe the events of adsorption of acid dye on the surface and in the interior of the new adsorbent particles obtained from ready–made garment cotton waste. The results of this research suggest the possibility of practical application in the decolorization of the colored waste waters of the textile industry providing a contribution to protecting the environment from both an economic and a practical point of view.
Ultra-short cementless anatomical stem for intracapsular femoral neck fractures in patients younger than 60 years
Authors: Melisik Marian , Hrubina Maros , Daniel Matej , Cibula Zoltan , Rovnak Marek , Necas Libor
Published: February 2022

The aim of this study was to present the midterm results of total hip arthroplasty with ultra-short anatomical cementless stem in the primary treatment of displaced intracapsular femoral neck fractures in patients younger 60 years. From 2006 to 2015, 17 hip arthroplasties (with the Proxima stem) were performed in group of 17 patients for the treatment of acute femoral neck fractures Garden type III and IV. The mean follow-up period was 112.7 (range: 64-148) months. Patients were evaluated retrospectively - clinically and radiographically, using the Harris hip scoring system during the year 2020. Seven males and ten females (mean age: 45.0 years) were included in the study. Each of them had one or more risk factors (time delay, comminution of the femoral neck, corticosteroids usage, the presence of coxarthrosis, rheumatoid arthritis, alcohol abuse, etc…), because of which the osteosynthesis was not performed. Harris hip scores were 6.3 preoperatively and 82.9 at the final follow-up. Three patients (17.6%) had complications: luxation, aseptic stem loosening (migration with subsidence - “varisation” and thigh pain) and deep infection. One patient (5.9%) with infection was revised. In carefully selected younger patients with displaced intracapsular femoral neck fracture, where the osteosynthesis as first treatment option should be associated with high risk of complication (avascular femoral head necrosis, non-union) due to the presence of risk factors, the primary total hip arthroplasty could be performed. The ultra-short cementless stem offers promising results in these rare cases in the midterm.
Extra-articular tibial deformity management in total knee replacement
Authors: Agarwal Sanjeev , Choi Sarah , Kumar Rakesh , Morgan-Jonnes Rhidian
Published: February 2022

Background : Presence of an extra-articular deformity in the femur or tibia poses a challenge to the surgeon undertaking knee replacement procedure. The conundrum is whether to correct the deformity beforehand, or accept the deformity and compensate for this through placement of the implant.

Material and Methods : This is a retro-spective study comprising six patients who had a knee replacement in the presence of an extra-articular deformity of the tibia treated at our centre. All six had the knee replacement without correction of deformity. The data evaluated included clinical outcome, mechanical axis correction, type of implant, and the use of any software / computer guidance.

The deformity was managed through planning of tibial resection without the need for pre-operative deformity correction.

Results : Mean age was 66.5 years. Mean coronal plane deformity in the tibia was 8.6 degrees. The hip- knee-ankle improved from a mean 12.6 degrees to 4 degrees. Mean Oxford knee score improved from a mean of 19 to 33.6.

Conclusion : Planning the tibial resection on the basis of mechanical axis of tibia allows correction of alignment without the need for preoperative correction.

Correction of the deformity may not be needed if the maximum tibial resection is less than 15 mm.
Metal wear debris generation in primary total knee arthroplasty: is it an issue?
Authors: Kellens Jonas , Berger Pieter , Vandenneucker Hilde
Published: February 2022

More durable total knee arthroplasties (TKAs) are needed, due to the rising life expectancy, the higher activity levels of patients and the growing concerns about aseptic loosening being caused by metal hypersensitivity. In response, different hypoallergenic metal coatings have been developed for TKAs. How- ever, possible adverse effects of these different metals (cobalt-chromium-molybdenum, zirconium, titanium and tantalum) have been neglected. The aim was to summarize the local and systemic adverse effects (including metal hypersensitivity), survival ratios, patient-reported outcome measures (PROMs) and the plasma metal ion concentrations of the different TKA coatings. A literature search on PubMed and EMBASE was performed. In total, 15 studies were found eligible. Common adverse effects of TKA were infection, loosening, pain, instability and hyper- coagulation disorders. Serious adverse effects related to TKA implants were not reported. The survival ratios and patient-reported outcome measures seem to confirm these good results. In contrast with chromium and cobalt, no significant differences were reported in the nickel, molybdenum and titanium concentrations. No significant differences between the hypoallergenic and standard TKA implants were found in terms of adverse effects, survival ratios and PROMs. A causal relationship between the common adverse effects and the different metals is unlikely. Due to the heterogeneity of the TKA implants used, no firm conclusions could be made. Further research with longer follow-up studies are needed to find possible adverse effects and differences. Thus far, the hypoallergenic implants seem to perform equal to the standard implants.
Treatment of open and comminuted mid-distal tibial fractures by bilateral external fixation combined with limited-internal fixation
Authors: Liang Hongsuo , Li Lin , Yang Jingye , Du Yongjun , Peng Wuxun
Published: February 2022

Open and comminuted mid-distal fractures often result from high-energy trauma, and a concomitant poor blood supply often leads to skin necrosis, infection, and bone union. To circumvent such complications, we used limited-reduction and bilateral-external fixators to treat open and comminuted mid-distal tibial fractures with compromised soft tissue. A retrospective series of 34 patients who had open and comminuted mid-distal tibial fractures and treated by bilateral-external fixators with limited-internal fixation were analyzed. Patients were followed for 10-25 months (mean: 12 months) post-treatment and osseous union was achieved in each case. The average union time was 16.3 weeks. Based on the Johner- Wruhs criteria, the retrospective series consisted of 21 ‘excellent’ cases, 8 ‘good’ cases, 4 ‘fair’ cases, and a ‘poor’ case. The total percentage of ‘excellent’ and ‘good’ cases of fracture recovery was 85.29%. Bilateral-external and limited-internal fixators pro- vided high bone union rate and excellent ankle-joint motion. Hence, it is an appropriate surgical approach for treating open and comminuted mid-distal tibial fractures with compromised soft tissue.
ANALISIS EFISIENSI PELAYANAN RAWAT INAP DI TINJAU DARI INDIKATOR PELAYANAN RAWAT INAP PADA BLUD RSUD dr. H. SOEMARNO SOSROATMODJO KAPUAS TAHUN 2017
Authors: Persadha Galih , Anhar Aus Al , Anshari Fakhrurrasyid
Published: February 2022

Activity that is routinely carried out al BLUD RSUD dr. H. Soemarno Sosroatmodjo Kapuas which calculate the efficiency of bed occupancy. Inpatient service indicators for the last 3 years have fluctuated but have not met the standards. The purpose of this research was to determine the efficiency of inpatient service based on indicators of inpatient service at BLUD RSUD dr. H. Soemarno Sosroatmodjo Kapuas in 2017. This type of research use descriptive quantitative cross sectional approach with observation method, namely observing and calculating directly in the field. Daily inpatient census from 00.00 to 24.00 at 08.00 is handed over to the medical record. In 2017 the BOR result 52,51%, AvLOS 2,30 days, TOI 2,99 days, and BTO 58 times. Based on the measurement of Barber Johnson Chart the BOR value in the efficient area is the Cempaka room, while VIP, Isolation, ICU, VK, Teratai, Mawar, Perinatology, Kenanga, Dahlia, and Anggrek are outside the area efficiently. BOR values under the Health Department standards and Barber Johnson need to be made efforts to improve the quality of services including by completing facilities and infrastructure and improving service quality and human resource skills to restore public confidence in the hospital.
GAMBARAN KEPATUHAN MINUM OBAT PADA PENDERITA TUBERKULOSIS DI PUSKESMAS PEKAUMAN KOTA BANJARMASIN
Authors: Isnani Nazhipah , Soediono Jhudi Bonosari , Muliyani Muliyani , Audina Rini
Published: February 2022

Tuberkulosis adalah penyakit infeksi yang disebabkan oleh bakteri tahan asam atau Mycobacterium Tuberkulosis. Di Puskesmas Pekauman Kota Banjarmasin, tercatat 101 pasien pada tahun 2017. Dan terdapat 27 kasus TB baru sejak bulan Januari 2018 sampai Juni 2018. Dua puluh diantaranya yang dapat dijadikan sampel pada penelitian ini. Penelitian ini bertujuan untuk Mengetahui gambaran kepatuhan minum obat pada penderita Tuberkulosis Pasien di Puskesmas Pekauman Kota Banjarmasin. Penelitian ini menggunakan metode deskriptif observasional nonanalitik, dengan desain penelitian observational studi. Jenis data primer dikumpulkan menggunakan metode wawancara dengan kuesioner terstruktur dan data sekunder dari puskesmas berupa data rekam medis pasien dengan menggunakan pendekatan cross sectional dengan pengambilan data secara kualitatif atau data yang bukan berbentuk angka. Berdasarkan hasil penelitian yang dilakukan didapatkan hasil gambaran kepatuhan pasien dalam minum obat pada fase intensif, fase lanjutan serta pemeriksaan dahak sebesar 100% dinyatakan patuh.
CORE STABILITY EXERCISE WITH BALL MENINGKATKAN KESEIMBANGAN PADA PASIEN STROKE DI KLINIK KARMEL
Authors: Hamzah Arfian , Fauziah Enny , Maulina2 Luluk
Published: February 2022

Stroke merupakan manifestasi klinis dari disfungsi otak, baik lokal maupun global, yang berlangsung dengan cepat bahkan lebih dari 24 jam. Stroke adalah penyakit cerebrovascular yang mengacu pada gangguan neurologis mendadak yang terjadi karena aliran darah yang terbatas atau terhenti melalui suplai arteri otak yang dikenal dengan Cerebro Vascular Accident (VSA). Penderita stroke akan mengalami gangguan keseimbangan, gangguan keseimbangan pada penderita stroke berkaitan dengan ketidakmampuan untuk mengatur perpindahan berat badan dan penurunan mobilitas otot. Penderita stroke berulang memiliki masalah dengan kontrol postur tubuh, sehingga menghambar pergerakan. Keseimbangan juga menjadi parameter bagi penderita stroke atas keberhasilan terapi. Penelitian ini untuk membuktikan bahwa core stability exercise with ball dapat meningkatkan keseimbanagn pada pasien stroke. Penelitian ini merupakan penelitian eksperimental dengan pre-test dan post-test grup. Sampel terdiri dari 22 orang, latihan diberikan 3 kali seminggu selama 6 minggu. Keseimbangan diukur dengan Berg Balance Scale Questionnaire (BBS questionnaire). Hasil penelitian ini menunjukkan bahwa core stability exercise with ball meningkatkan keseimbangan pasien stroke secara signifikan (p=0.001). Sehingga disarankan fisioterapis untuk mengaplikasikannya pada pasien stroke untuk meningkatkan keseimbangan.
ПОНЯТТЯ АНДРОГІННОСТІ ЖІНОЧИХ ПЕРСОНАЖІВ У РОМАНАХ «ГОРА» ТА «ВІДСВІТИ ПОЛУМ’Я» ВАСИЛЯ КЛИМА
Authors: НІМІЖАН-БОДНАРЮК О. І.
Published: February 2022

У статті основна увага зосереджена на провідних жіночих персонажах у романах українського письменника із Румунії Василя Костянтиновича Клима «Гора» та «Відсвіти полум’я». Зокрема, вказано на застосований автором прийом розкриття їх психоформальних виявів через андрогінну форму мислення. У зв’язку із цим образи героїнь митець специфікує через деталізацію їхньої потенційної діяльнісності, інтелектуального осягнення світу, звільнення від консервативних суспільних рамок, що формує типаж жінок нового типу. Вони поєднують у собі риси двох статей, що дозволяє їм виражати високу адаптивність до різних життєвих проблем і неординарно підходити до їх правильного вирішення. Жіночі персонажі досить сильно впливають на чоловічі, які є яскраво вираженими репрезентантами маскулінного світобачення, і розкривають ці властивості найчастіше під час контактування із неприкритою діяльнісністю жінок андрогінного типу. Оскільки протагоністки одночасно поєднують дихотомічні поняття гострого розуму та глибокої емоційності, Василь Клим «офілософлює» їхні образи як такі, що живуть у патріархальному суспільстві й володіють не менш міцними характерами. Однозначно, вони не завжди вміли справлятися зі своєю андрогінністю і без суттєвих психологічних потрясінь направляти власну діяльнісність у правильне русло. Вони характеризуються високою адаптивністю до різних ситуацій, що забезпечується поглибленим аналітичним мисленням відносно стереотипних соціально-поведінкових виявів. Хоч на перший погляд вони виглядають дуже різними, проте основоположні риси їхнього опису дозволяє класифікувати за трьома групами: жінка-жертва, жінка-правдошукачка та жінка гармонійна. До першої групи належать образи, які обрали для себе роль жертви, відмовляються розуміти патріархальний світ, інтелектуально вміють випереджати події в чоловічому світі, не протидіють стереотипному устрою. Друга група характеризується жінками, які не розділяють гендерні позиції, випереджають ментально свій час, виражають свою максимальну діяльнісність та професіоналізм. До останнього типу належать персонажі, які гармонійно поєднують високу андрогінність та інтелектуальність із сімейним добробутом у так званому камерному світі для двох.
КОГНІТИВНИЙ КОНСОНАНС ЯК ФАКТОР КОГНІТИВНОЇ ЕКВІВАЛЕНТНОСТІ РЕТРАНСЛЯЦІЙ ЧАСОВО ВІДДАЛЕНОГО ПЕРШОТВОРУ
Authors: БОЙКО Я. В.
Published: February 2022

У запропонованій розвідці обґрунтовано поняття когнітивного консонансу з позицій теорії і практики перекладу як фактору когнітивної еквівалентності ретрансляцій (діахронної множинності перекладів) часово віддаленого першотвору. Матеріалом дослідження слугували часово віддалений першотвір – трагедія У. Шекспіра “King Lear” (1605) – та її діахронні ретрансляції, авторами яких є П. Куліш (1880), М. Рильський (1941) і В. Барка (1969). У статті охарактеризовано феномен діахронної множинності перекладів часово віддаленого першотвору як проблему перекладознавства, а також описано різні соціально-історичні контексти і літературні стилі, у яких були виконані аналізовані діахронні ретрансляції. У дослідженні визначається співвідношення консонансу та дисонансу як категорій гармонії теорії музики, а також специфіка когнітивного консонансу саме з позицій теорії і практики перекладу. Крім того, пояснюються чинники, від яких залежить ступінь наближення діахронних ретрансляцій до оригіналу. Когнітивна еквівалентність розуміється як результат гармонійної тотожності мисленнєвого процесу автора і перекладача, що є підґрунтям функційно-комунікативної рівноцінності та прагматичної рівнозначності оригіналу та його діахронних ретрансляцій. Встановлено параметри, за якими виявляється когнітивна еквівалентність одиниць оригіналу і одиниць перекладу в умовах когнітивного консонансу. Обґрунтовано два таких різновиди когнітивної еквівалентності оригіналу і перекладу: повну когнітивну еквівалентність (повну рівноцінність і тотожність форми та змісту) і часткову когнітивну еквівалентність (порушується тотожність одиниць оригіналу й одиниць перекладу у плані форми, але зберігається тотожність у плані змісту).
КОНЦЕПЦІЯ ЛІНГВІСТИЧНОЇ БАЗИ ДАНИХ «ФУНДАМЕНТАЛЬНІ ЕМОЦІЇ ЛЮДИНИ В АНГЛІЙСЬКІЙ ФРАЗЕОЛОГІЇ»
Authors: КОЛЬЦОВА О. С.
Published: February 2022

У статті опрацьовано концепцію лінгвістичної бази даних «Фундаментальні емоції людини в англійській фразеології» з опертям на вивчення емоційної картини світу. Успішна реалізація мети потребує виконання таких завдань: 1) схарактеризувати кваліфікаційні ознаки бази даних та окреслити її переваги порівняно з іншими файловими системами; 2) ознайомитись із досвідом створення фактографічних лінгвістичних баз даних у вітчизняній і закордонній фразеології; 3) визначити теоретико-прикладні засади укладання ЛБД «Фундаментальні емоції людини в англійській фразеології». Об’єктом дослідження постає база даних як упорядкована сукупність даних, призначених для зберігання, накопичення та обробки інформації за допомогою комп’ютерних технологій. Предметом розвідки є лінгвістична база даних «Фундаментальні емоції людини в англійській фразеології». При розробці лінгвістичної бази даних використано метод концептуального проєктування, метод суцільної вибірки, метод семантичних полів, методологічний прийом співвіднесення компонентів фразеологічної одиниці (ФО) зі знаками різних семіотичних галузей культури. Схарактеризовано кваліфікаційні ознаки бази даних та окреслено її переваги порівняно з іншими файловими системами. Окреслено досвід створення фактографічних лінгвістичних баз даних у вітчизняній і закордонній фразеології. Визначено теоретико-прикладні засади укладання зазначеної лінгвістичної бази даних. Стратегія створення лінгвістичної бази даних спрямована на багаторазове різноаспектне використання. Формат представлення фразеографічних даних у вигляді лінгвістичної бази даних дозволяє реалізувати новий підхід до вивчення емоційної картини світу.