bluuebunny/crossref_metadata_2025 huggingface dataset:
Revolutionizing cancer treatment by boosting dendritic cell vaccine efficacy with graphene oxide
Authors: Mohamed Rafeezul , Ramli Muhammad Mahyiddin , Reshak Ali H , Osman Nurul Huda , Aziz Mohd Yusmaidie , Mansor Mohd Syahir
Published: July 2023

Dendritic cells (DCs) are potent antigen presenting cells that play a crucial role in stimulating T cell responses against cancer. DC vaccines have been utilized as an immunotherapy approach for cancer treatment, but their effectiveness is hampered by challenges in the tumor microenvironment. Graphene oxide (GO), a cutting-edge carbon-based nanomaterial, has shown promise in modulating DC activation and function. This review highlights the recent advancements in DC vaccines and explores how GO can enhance their efficacy for cancer treatment. By leveraging the unique properties of GO, such as its biocompatibility and immunomodulatory effects, DC vaccines can potentially be optimized to overcome the limitations of the tumor microenvironment and achieve improved outcomes in cancer immunotherapy.
Modelling of the Viscosity Effect of Heave Plates for Floating Wind Turbines by Hydrodynamic Coefficients
Authors: Ciba Ewelina , Dymarski Paweł
Published: July 2023

One of the methods of modelling the movement of floating wind turbines is the use of the diffraction method. However, this method does not take into account the influence of viscosity; therefore, in many cases, it needs to be extended with a matrix of appropriate coefficients. The effect of viscosity causes both the added mass coefficient and the damping coefficient to increase. The determined coefficients were entered into the ANSYS AQWA program, and the calculation results of the transfer function determined with the use of linear and quadratic damping were presented. The results were compared with the results of the experiment, indicating greater convergence for the quadratic model.
Material Characteristic of an Innovative Stent for the Treatment of Urethral Stenosis
Authors: Kurowiak Jagoda , Mackiewicz Agnieszka , Klekiel Tomasz , Będziński Romuald
Published: July 2023

The appropriate development and customisation of the stent to the urethral tissues requires the determination of many factors such as strength and degradation. Given the distinctive conditions of urethral tissues, it is important that the design of the stent be properly developed. The selection of a stent material requires knowing its material characteristics and verifying that they are suitable for the future implantation site. In the present study, the development of a polydioxanone (PDO)-based stent was undertaken. The PDO material was fabricated using an additive technique – 3D printing. Then, in vitro tests were performed to determine the degradation time of the material under conditions simulating an aggressive urinary environment. The changes in the parameters of mechanical properties before and after the degradation period were determined, and the changes in the structure of the material before and after degradation were observed. Numerical analysis was performed for the proposed stent design. The results showed that PDO has good mechanical properties, but its degradation time is too short to be used in a urethral stent. Among the innovations of the studies conducted are bending strength tests, which is not a frequently considered aspect so far.
Nancy Art Nouveau Architecture
Authors: Krastiņš Jānis
Published: July 2023

The north-eastern French city of Nancy is one of the centres of Art Nouveau. It has been analysed in detail in many classical reviews Art Nouveau, but mainly in relation to decorative applied art works produced at the Nancy School of Art. The study pays attention also to the Nancy architecture. The architectural and artistic qualities of the iconic Art Nouveau architectural monument Villa L. Majorelle are analysed in detail, and the basic data about works of É. André, H. Gutton, J. Hornecker, L. Weissenburger, and other Nancy architects are systematized, indicating their place both in the cityscape of Nancy and in the historical context of Art Nouveau architecture in general.
Electrode surfaces based on multiwall carbon nanotubes-chitosan composites validated in the detection of homocysteine biomarkers for cardiovascular disease risk monitoring
Authors: Oonchit Suparerk , Cherdhirunkorn Benya , Tharabenjasin Phuntila , Pabalan Noel , Chintanavilas Kumpol , Marks Robert , Parcharoen Yardnapar , Pechyen Chiravoot
Published: July 2023

This study aimed to modify screen-printed carbon micro-electrode surfaces by coating them with multiwall carbon-based nanotubes conjugated with chitosan and then validated the formed multiwall carbon-based nanotubes-chitosan coated screen printed carbon micro-electrode for the detection of homocysteine, a biomarker analyte known as a risk indicator in cardiovascular disease. The microstructure surface and crystallographic structure stability of the formed multiwall carbon-based nanotubes-chitosan obtained at formed multiwall carbon-based nanotubes per chitosan ratios of 1:1, 2:1, 3:1, and 4:1 were examined via field emission scanning electron microscopy, X-ray radiation, Raman spectroscopy, surface area and pore size, and thermogravimetric analyses. Homocysteine solutions at 30–100 µM were measured by cyclic voltammetry using the different formed multiwall carbon-based nanotubes-chitosan compositions as sensor electrodes. That with an optimal formed multiwall carbon-based nanotubes per chitosan ratio of 4:1 showed the highest crystallinity and electrical conductivity and gave a high coefficient of determination (R2 = 0.9036) between the homocysteine concentration and the oxidation current detection over an operating range of 30–100 µM. This new composite microelectrode for detecting homocysteine concentration makes it a promising candidate for clinical applications.
A Cell-Based Double Reporter Gene Splicing Assay for Therapeutic Screening in Myotonic Dystrophy
Authors: Udosen Inyang U. , Granados Javier T. , Brook John David
Published: July 2023

The study has developed a model splicing construct assay system based on splicing misregulation, one of the major molecular features associated with myotonic dystrophy. The splicing construct assay has double reporters for intron 2 splicing in chloride channel (CLCN1). The CLCN1 transgene splicing construct assay was used to transfect wild type and DM fibroblast cell lines and the clones generated showed that it enabled quantification of splicing efficiency in transgene construct. Validation of the DM fibroblasts containing transgene splicing construct was performed by differentiating the DM fibroblasts into myoblasts which exhibited a switch in CLCN1 splicing construct which was consistent with that associated with myotonic dystrophy (DM) condition. The myoblast derived from fibroblasts cell-based gene-splicing assay was subsequently applied in therapeutic screening in small throughput screens of 113 compounds which identified Protein Kinase C inhibitors- hypericin and Ro-31-8220 as potential therapeutic agents. The CLCN1 gene-splicing assay is a good model system for application in therapeutic screening in myotonic dystrophy because its double reporters facilitated quantification of effect putative drug on correction of misregulated splicing.
Free-Space Optical Communication with an Optimized Lipschitz Exponent for Biosignal Telemetry
Authors: Chokkalingam Mathuvanesan , Murugaiyan Chinnadurai
Published: July 2023

Healthcare monitoring is a rapidly developing network in the field of advanced medical treatment. The network combines the ideology of wireless communication, signal processing, medical information and real-time processing units to support the medical monitoring system. The proposed work focuses on the development of a Free-Space Optical (FSO) system to transmit the biosignals from a remote distance to the physician. Generally, the data transmitted over the FSO system is affected by various atmospheric conditions such as air medium, O2, and H2O molecules. To tackle these problems, the Biosignals Electrocardiogram (ECG) and Electroencephalogram (EEG) are processed in the Optimized Lipschitz Exponent (OLE) function before transmission over the FSO medium. In this novel technique, the OLE function measures the informative data from the biosignals by calculating the local regularities and singularity. This collects the most informative signals and transmits them in the signal over the FSO medium. This particular hybridization helps to transmit the required data without distortion. The Bit Error Rate (BER) of 10−9 is obtained, which satisfies the healthcare monitoring condition. The result section shows that the proposed model has minimum losses compared to the original signal.
Civil Society Organizations, the Good Friday Agreement, and the Northern Ireland Peace Process
Authors: Byrne Seán , Mallon Brett , Yavuz Mehmet
Published: July 2023

A qualitative methodology was used to interview 120 participants from 2010 and 29 participants from 2020 who shared their experiences and perceptions about the Good Friday Agreement (GFA) and their peacebuilding work. Longitudinal findings reveal that the participants were critical of the Agreement and the disconnect between politicians and the grassroots as well as recognizing that the Agreement has brought about relative peace in Northern Ireland. While the participants attest to the relative success of the GFA, they also note several criticisms including sectarian politics, new paramilitaries, Brexit, legacy of the past, continuing divisions in Northern Ireland, and the disconnect between politicians and local community peacebuilders. The participants’ criticisms are significant as they attest that while the social peace at the grassroots level is moving forward the political peace is not as evidenced by the recent Unionist backlash against Brexit.
First Record of Acanthocephalus lucii (Müller, 1776) Lühe, 1911 (Paleacanthocephala, echinorhynchidae) in Minnow (Phoxinus lumaireul Linnaeus, 1758) from Belčišta Wetland (North Macedonia)
Authors: Blazhekovikj-Dimovska Dijana , Stojanovski Stojmir , Velkova-Jordanoska Lidija
Published: July 2023

In our study, a total of 33 specimens of three cyprinid fish (Squalius squalus, Phoxinus lumaireul, and Pelasgus minutus) from Belčišta wetland (south-west Macedonia) were subjected to a parasitological investigation, by season. One specimen of Acanthocephalus lucii was found in autumn, in intestines of minnow (Phoxinus lumaireul Linnaeus, 1758). The record of Acanthocephalus lucii in minnow is considered as the first in N. Macedonia. At the same time, minnow represent a new host for this parasite worldwide.
Proximate Composition of Sarotherodon melanotheron and Socio-Economic Analyses of Cast Net Among Artisanal Fishers in Lagos Lagoon (Nigeria)
Authors: Ogunbambo Mogbonjubola Mutiat , Benson Annie Eunice
Published: July 2023

Proximate composition of the wild-caught Sarotherodon melanotheron and the socioeconomic analyses of cast net among artisanal fishers in Lagos Lagoon (Nigeria), were examined in the dry season of 2021 and 2022. No significant (P < 0.05) variation was found in the proximate content of the fish. The protein content ranged from 61.74 ± 3.20 g/100 g to 63.13 ± 0.64 g/100 g in 2021 and from 53.13 ± 3.27 g/100 g to 58.38 ± 0.47 g/100 g in 2022, with highest value in November 2021 and decreased thereafter till late dry season (April). Lipid content showed the opposite trend (except in February), increasing from early to late dry season. The return on investment averaged at 10.72, with lowest being ‒0.60 and highest found to be 24.00. The use of cast nets fishing gear is profitable.
Analisis Penggunaan Aplikasi iPusnas Di Kecamatan Cileungsi Dalam Memenuhi Kebutuhan Informasi
Authors: Hidayat Rizki Ismail
Published: July 2023

Penelitian ini membahas tentang analisis penggunaan aplikasi iPusnas di kecamatan Cileungsi dalam memenuhi kebutuhan informasi. Metode penelitian yang digunakan dalam penelitian ini adalah metode kualitatif. Fokus penelitian pada persepsi warga kecamatan Cileungsi sebagai pengguna aplikasi iPusnas dalam memenuhi kebutuhan informasi. Pengambilan data dengan metode survei. Peneliti memberikan formulir kepada warga kecamatan Cileungsi berisi pertanyaan mengenai penggunaan aplikasi iPusnas untuk memenuhi kebutuhan informasi. Hasil penelitian menunjukkan penggunaan aplikasi iPusnas di kecamatan Cileungsi telah memberikan kemudahan dan manfaat bagi warga masyarakat dalam memenuhi kebutuhan informasi. Konten-konten aplikasi perpustakaan digital iPusnas dapat dipahami dengan mudah dan digunakan masyarakat khususnya warga kecamatan Cileungsi. Analysis of the Use of iPusnas Application in Cileungsi District In Meeting Information Needs. This study discusses the analysis of the use of the iPusnas application in the Cileungsi sub-district in meeting information needs. The research method used in this study is the qualitative method. The research focuses on the perception of residents of the Cileungsi sub-district as users of the iPusnas application in meeting information needs. Data collection by survey method. Researchers provided a form to residents of the Cileungsi sub-district containing questions regarding using the iPusnas application to meet information needs. The results showed that using the iPusnas application in the Cileungsi sub-district has provided convenience and benefits for community members in meeting information needs. The contents of the iPusnas digital library application can be easily understood and used by the community, especially residents of the Cileungsi sub-district.
Andri Magnason’s The Story of the Blue Planet
Authors: Nathanael Tanja
Published: July 2023

The reflection describes my experience of using Andri Magnason’s The Story of the Blue Planet as a hopeful guide toward classroom discussions about sustainable futures. Magnason’s novel helps students appreciate the environmental choices we are currently facing and provides an outline for what needs to be done. Just like the children of the Blue Planet, we face similar challenges to overcome resistance to climate literacy and action. Magnason’s message is hopeful and gestures at an ecotopian future. The book suggests that the choice to live sustainably is not as hard as it may seem.
Critical Dialogue
Authors: Werthwine Kate , Panos Alex
Published: July 2023

This is a conversation between Kate Werthwine, a high school English teacher in Pasco County, Florida, and Alexandra Panos, a former middle grades ELA teacher and current Assistant Professor of Literacy Studies at the University of South Florida and Associate Editor of Climate Literacy in Education. Kate and Alex have known each other for almost four years and have spent much of their time together thinking and talking about climate and ecojustice and its intersection with literacy, with diverse kinds of text, and with where their bodies are on this living earth. This conversation is focused on Kate’s artwork—published in this volume—and discusses how the current laws and policy practices in Florida have impacted the stories that get shared in classrooms, including those that support learners in their own journeys to understand who they are and where they are from.
Finding a Way Through: Teaching with Naomi Klein’s How to Change Everything
Authors: Hunt Kirsten
Published: July 2023

In this reflection I share insights from reading Naomi Klein’s How to Change Everything with undergraduate elementary education majors. I discuss how Klein’s book offered pre-service teachers clear pathways for alleviating their own eco-anxiety and how it equipped them to help their future students navigate climate emotions.
Humanity’s Reliance on the More-Than-Human in Shaun Tan’s Tales from the Inner City
Authors: Coltman Julia
Published: July 2023

Various aspects of human life—including art, media, and culture—are becoming increasingly informed by the climate and environmental crises. Shaun Tan’s Tales from the Inner City illustrate and respond to this emergency, rising questions about the consequences of humanity's disconnect from the nonhuman world. Tan’s message is wistful but not hopeless: although reestablishing balance with nature will not be easy, it is the only goal that matters.
Soil applied cobalt alters the growth parameters and dry matters production of Bhendi (Abelmoschus esculentus L.)
Authors: Jayakumar Kaliyamoorthy , Aksah P.
Published: July 2023

In this study, an economically important crop plant Bhendi (Abelmoschus esculentus L.) were treated with various concentrations of cobalt to test its effect on the growth of the plants. For the growth of many plants, cobalt is necessary. Conversely, higher amounts of cobalt are poisonous to plants. Seeds were cultivated in pots with soil that had not been treated (the control) and soil that had cobalt added to it in doses of 50, 100, 150, 200, and 250 mg kg-1. For each sample, the several morphological characteristics including root length, shoot length, number of nodules, total leaf area, dry weight of root and shoot per plant, and leaf area were measured. Soil cobalt level of 50 mg kg-1 was found beneficial to the plants.
Saline water irrigation in agriculture: A case study of mangrove's salinity tolerance level
Authors: Rajalakshmi A.K. , Elavazhahan P. , Manivannan P.
Published: July 2023

Standardizing the saline water irrigation is an important step towards saline water irrigation in agriculture. An experiment was conducted to study the salinity tolerance level of mangrove plant, Lumnitzera racemosa Willd. Under pot culture system. different levels of salinity (0, 100, 200, 300, 400, 500, 600, 700, 800, 900 and 1000 mM NaCl) were imposed on the plants and the variations in mineral content levels was analyzed. Samplings were done on 60, 120 and 180th days after NaCl treatment. From the results it is clear that Mineral constituents such as nitrogen, phosphorus, potassium, calcium and magnesium were increased upto the optimum concentration and there by the tolerance level of this mangrove towards salinity was calculated.
TEKANAN DARAH SISTOLIK LEBIH TINGGI PADA SORE DARIPADA PAGI HARI PADA USIA 45-65 TAHUN
Authors: Wulandari Anindra Novita , Samara Diana
Published: July 2023

Blood pressure is the pressure of the blood pumped by the heart against the walls of the arteries and is divided into systolic and diastolic. Blood pressure decreases 10% in the evening at normal circadian rhythms and rises again in the morning. Insomnia is one of the factors that can affect blood pressure. This study aims to look at differences in morning and evening blood pressure at the age of 45–65 years. The research method uses observational analytic with a cross sectional approach. Collecting samples using consecutive non-probability sampling. Subjects aged 45–65 were 301 people. Blood pressure was measured in the morning and evening. Insomnia data obtained based on a questionnaire. The statistical test used paired t test with a significance of p <0.05. The results showed a significant difference between morning and evening systolic blood pressure (P = 0,023), but there was no difference between morning and evening diastolic blood pressure (P = 0,224). There is a relationship between insomnia and morning blood pressure (p=0,001). The conclusion from the research results is that systolic blood pressure in the afternoon is higher than in the morning. Morning blood pressure is associated with difficulty sleeping at night.
The Emergence of Multicultural Characteristics in Virtual Team
Authors: Karim Daniel , Gustomo Aurik , Wisesa Anggara
Published: July 2023

The advancement of information and communication technology grant access for businesses to reach global workforce. In a condition where companies hire their employee from cross-border market, the exposure of multicultural differences will be more in contact. Some of the problem faced by virtual multicultural team are cultural discrepancy, communication problem, long distance conflict, and lack of synergy. The objective of this study is to explore the multicultural characteristics emerged from virtual team activity to minimize the problem. This research adopts a case study to examine the comprehensive understanding of virtual multicultural team activity and get new insight from dwelling activity into the context directly. This study has two results: a virtual team and multicultural team characteristics in digital company and Hybrid company. This study can help practitioners identify what multicultural level of focus is well-suited to their current business model and give researcher an overview of future research on the alternatives in managing virtual multicultural team by building virtual multicultural team framework.
Keywords — Multicultural; Virtual Team, Hybrid Company, Digital Company
Does Employee Empowerment as a Mediating Variable the Linking of Transformational Leadership on Employee Performance?
Authors: Siswanto Siswanto , Febriansyah Fatchan Maulana , Ridwan A Muhtadi
Published: July 2023

This study aims to investigate whether employee empowerment (EE) as a mediator variable of the mechanistic pathway of transformational leadership (TL) influences employee performance (EP). A quantitative method was employed. The samples were 109 employees of regional companies in Magetan City, East Java and were collected from questionnaires. SEM-PLS was employed for data analysed. The results showed that transformational leadership directly affects employee performance. Work motivation has a role as a mediator variable from transformational leadership mechanisms to employee performance. Meanwhile, employee empowerment does not have a role as a mediator variable in the path of transformational leadership mechanisms on employee performance. The mediating role of employee empowerment in the mechanistic pathway is still contradictory. Therefore, the investigation of employee empowerment as a mediator variable in the mechanism is still recommended for future research.
Keywords— Employee Empowerment; Employee Performance; Transformational Leadership; Work Motivation
YouTube Influencer: How Source Credibility and Information Quality Influence Destination Image and Visit Intention of Young Travelers?
Authors: Laurance Angelina Alice , Wijaya Serli , Thio Sienny
Published: July 2023

This study aims to analyze the effects of YouTube influencers’ source credibility and the information quality of the platform on destination image and young travellers’ intention to visit a destination. Stimulus-organism-response (SOR) theory was adopted to develop the tested research model. This study applied a quantitative approach where primary data was collected through online surveys to 198 YouTube subscribers who had watched the examined YouTube channels’ content. The PLS-SEM technique was utilized to assess the structural model in the study. The results of this study show that source credibility had a significant positive effect on information quality, destination image, and visit intention. The information quality positively affected destination image but did not directly impact the visit intention. Furthermore, the destination image significantly mediates the effect of source credibility and information quality on visit intention. This study enriches the literature on the relationships among source credibility, information quality, and how these credibility and information quality could influence the destination image and young  travellers’ intention to visit a destination in an emerging country like Indonesia.
Keywords— Destination Image; Information Quality; Source Credibility; Visit Intention: YouTube Influencer; Young Travelers.
Research Trends and Mapping of Price Limits and Stock Prices in ASEAN 5: A Bibliometric Analysis
Authors: Alexandri Mohammad Benny , Narimawati Umi , Supriyanto Supriyanto
Published: July 2023

The purpose of this study is to examine and analyze research trends and mapping of price limits and stock prices in ASEAN 5. This type of research is qualitative research. The research variables are Price Limit and Stock Price. The data collection technique used was bibliometric analysis from the Scopus database from 1996 to 2022. The number of research samples was 52 samples. The data analysis technique uses bibliometrics with the VOS viewer software program. The findings of this study indicate that 52 articles have been selected, with the number of publications increasing every year. Indonesia, Malaysia, the Philippines, Thailand and Singapore have an important role to play in the article price limits and share prices on Scopus as well as price limits reducing the volatility of stock returns, overcoming overreactions and not disrupting trading activities.
Keywords: Price limits, Bibliometrics, Scopus, VOSviewer, ASEAN 5.
Penyematan Fonem Vokal pada Gairaigo di Album Traveler Karya Official髭男dism (Higedan)
Authors: Paradida Yulia Putri , Luhulima Fiona Djunita Natalia , Tarigan Marsten Lihardo
Published: July 2023

Tujuan penelitian ini mengidentifikasi penyematan fonem vokal pada gairaigo dalam lirik lagu Jepang karya Higedan dan mendeskripsikan perubahan mora beserta silabelnya. Manfaat penelitian ini, pembelajar bahasa Jepang dapat memahami proses terjadinya penyematan vokal pada gairaigo secara detail dalam lirik lagu bahasa Jepang. Teori yang digunakan adalah teori Hirayama tentang fonem vokal dalam bahasa Jepang, teori Kawarazaki dan Kubozono tentang penyematan fonem vokal pada silabel tertutup, dan perubahan silabelnya dalam gairaigo, teori Sutedi tentang mora dan silabel. Metode penelitian ini metode kualitatif dengan pendekatan deskriptif. Sumber data dari album lagu Traveler grup band Jepang Official Hige Dandism (Higedan) dengan data berupa gairaigo yang mengalami proses penyematan vokal. Peneliti menggunakan teknik studi pustaka untuk mengumpulkan data, kemudian menganalisis dengan teknik deskriptif. Hasil temuannya yakni, gairaigo yang mengalami proses penyematan vokal sebanyak 15 kata yang dibagi menjadi 3. Pertama, penyematan fonem vokal di awal kata sebanyak 5 kata, yakni furiidamu (フリーダム), adobanteeji (アドバンテージ), sutookaa (ストーカー), kurosuwaado (クロスワード) dan sutoorii (ストーリー ). Kedua, penyematan fonem vokal di tengah kata sebanyak 2 kata yakni, iesutadai (イエスタデイ) dan kontorooru (コントロール). Ketiga, penyematan fonem vokal di akhir kata sebanyak 8 kata yakni, poketto (ポケット), patto (パット), binteeji (ビンテージ), endo (エンド),  fitto (フィット), taaminaru (ターミナル), rokku (ロック),  dan souru (ソウル). Proses penyematan fonem vokal ini juga memengaruhi terjadinya perubahan mora dan silabel.
Kata kunci: fonem vokal; gairago; lirik lagu Higedan; penyematan vokal.
Disjunctive Questions in Biblical Hebrew: A Syntactic, Semantic, and Pragmatic Analysis
Authors: Scheumann Jesse
Published: July 2023

A disjunctive question presents an alternative to a previously-expressed state of affairs. Biblical Hebrew has four constructions for forming disjunctive questions. After an initial hă-question, the second can be introduced with hă, ʾim, wəʾim, or ʾô. While Hebrew reference grammars simply acknowledge the variation, this paper systematically addresses these constructions and distinguishes them on syntactic, semantic, and pragmatic grounds. The key results are a finer distinction between conjunction and disjunction and a recognition of how ellipsis discriminates between polar and alternative questions.
The Peshitta to Ezekiel, the Context of its Translation, and the Identity of its Translators
Authors: Mushayabasa Godwin
Published: July 2023

The Peshitta to Ezekiel has recently been described as a translation that closely represents the frames in the Hebrew text with corresponding frames in the natural Syriac language of the time of its translation. Such an approach to translation entailed a novel translation technique, as far as the translations of the Scriptures in the period up to the first three centuries CE were concerned. Such a characteristic feature of the translation, together with other socio-political conditions leads us to reflect on the ongoing question about the identity of the translators as well as the motivations behind their translation. A close literary and historical analysis of these factors showed that the Peshitta to Ezekiel would have been produced for a Christian community, rather than for Jews.
An Overview of Multiple Hydrogel Formulations for Wound Healing
Authors: . Aishwaray , Das Saumya , Pandey Ananya , . Gajender
Published: July 2023

Wound healing is a complicated and active process involving four perfectly synchronized processes that compose the typical biological mechanism of wound healing in the body: hemostasis, inflammation, proliferation, and remodeling. In order to successfully healing of wounds, these four steps need to take place in the right order and timeframe. There are distinct types of wound healing, like acute and chronic wound healing, based on various conditions and causes. One or more steps of this operation may be impacted by a variety of variables, which may hinder or result in improper wound healing. The ideal wound dressing is crucial to heal the wound and keep it from getting infected again. Hydrogel is ideal because of its anti-inflammatory, microbiological, and readily available qualities. Numerous variables may interfere with or result in improper wound healing at one or more stages of this procedure. The appropriate wound dressing is crucial to heal the wound and prevent secondary infections. This page lists some of the numerous formulations where hydrogel is most suitable and frequently used now a day. This is because of its anti-inflammatory, microbiological, and easily accessible qualities.
Validated HPTLC Analysis for Estimation of Quercetin in Seeds of Anethum graveolens
Authors: Lote Sukeshini , Agrawal Surendra , Ghune Shirin , Gurjar Pravina
Published: July 2023

A high-performance thin layer chromatography (HPTLC) method for the quantification of quercetin was developed on methanolic extract of dill (Anethum graveolens) seeds and subsequently validated. A suitable mobile phase was used to establish the HPTLC method, ethyl acetate, toluene, methanol, chloroform, and formic acid (2:3:3:2). A densitometric analysis was done at 366 nm of wavelength. Quercetin has an Rf value of 0.55. In the dilution range of 100 to 800 ng per band, quercetin revealed a linear connection with r2= 0.9938 in the calibration’s linear regression analysis. By conducting replication analysis on 2 separate days and one day, accuracy was verified. The standard addition method was used to conduct recovery studies to validate accuracy. The quercetin recovery rate was 98.60% on average. Five replicates of each of the three standards were used to detect the system suitability parameter. With regard to both the peak area and the Rf value, the %RSD was observed to be under 2%. The mobile phase concentration was altered from Toluene: Ethyl acetate: Chloroform: Methanol (2:3:3:2) to (3:2:2:3) with few drops of formic acid. It was found to have a %RSD of peak area below 10%, the robustness of the method was assessed. The developed HPTLC method was discovered to be easy to use, precise, accurate, suitable, and robust for estimating quercetin from dill seed extract.
Methacrylic Acid-Acrylamide based ZnO Hydrogel Nanocomposite Assisted Photocatalytic Decolorization of Methylene Blue Dye
Authors: Alkaim Ayad F , Abdulrazzak Firas H , Essa Shaimaa M , Altimari Usama S , Ramadan Montather F , Aljeboree Aseel M
Published: July 2023

In this research, preparation of methacrylic acid-acrylamide based ZnO hydrogel nanocomposite (MAA-AM)/ZnO hydrogel nanocomposite by way of co-polymerization via used acrylate acid (AA) (or acrylate salt) (AA) or methacrylic acid (MAA)) and acrylamide (AM). Nanocomposites based on acrylate are characterized via being hydrophilic and able to retain water. Nanocomposite properties were studied using different techniques (FE-SEM, TEM, and EDX). The photocatalytic degradation of methylene blue MB dye under different conditions was studied using nanocomposite like time of irradiation, mass of catalyst (MAA- AM)/ZnO hydrogel nanocomposite, initial MB dye concentration onto photocatalytic degradation and reactivation were studied. The result increases the photocatalytic degradation with the rise weight of catalyst (MAA- AM)/ZnO hydrogel nanocomposite range (0.1–0.25 g). Too, a decrease in photocatalytic degradation was observed with an increase in MB. Observed that after reuse, ((MAA- AM)/ZnO) nanocomposite hydrogel appear photocatalytic efficiency from of the use 1 to 6 cycle 87.88 to 58.87%, showing that ((MAA- AM)/ZnO hydrogel nanocomposite surface appear good stability.
Isolation and Identification of Phenolic Profiles in Selected Himalayan Wild Berries and Determination of their Antimicrobial Activity
Authors: Bhadauria Preeti , Rathore Kamal S.
Published: July 2023

A fundamental source of food and medicine for nearby Himalayan populations is the diversity of plants. The percentage yield of extract, phytochemicals, and minimum inhibitory concentration (MIC) for the extracts Euterpe oleraceae, Vaccinium myrtillu, Phyllanthus embilica, Rubus ellipticus, and Rubus niveus were determined. The clinical and laboratory standards Institute’s micro broth dilution method was used to assess these extracts’ antimicrobial effects on Klebsiella pneumoniae and Pseudomonas aeruginosa, while the purification of the positive extract was done by high-pressure liquid chromatography. Phytochemical analysis was done to determine the secondary plant metabolites, including alkaloids, polyphenols, glycosides, tannins, flavonoids, carbohydrates, steroids, and saponins. All five of the studied plants’ extracts showed antibacterial activity against one or more tested microorganisms. Several phenolic acids (chlorogenic acid, salicylic acid, ellagic acid, ferulic acid, gallic acid, and caffeic acid were detected in all extracts. The R. ellipticus extracts with petroleum ether, chloroform, methanol, and water show a maximum yield between (64–56%) except R. ellipticus extract with hexane (25.82%) showed a low yield. All the extracts have major quantities of carbohydrates, flavonoids, and phenols. These results suggested that produced antimicrobial activity was due to the presence of phytoconstituents in all extracts.
Development and Validation of HPLC And HPTLC for Simultaneous Analysis of E and Z Guggulsterone, A-11–KBA And 11–KBA from Herbal Formulation
Authors: Ahmad Sufiyan , Dashpute Aakanksha , Patil Mukesh , Bhise Manish , Barde Lokesh , Musmade Kranti , Tare Harshal
Published: July 2023

RP-HPLC and HPTLC are two easy, sensitive, efficient, and accurate procedures that allow for simultaneous estimates of Z and E guggulsterone, A-11-KBA, and 11-KBA. For the HPLC method, we recommend the use of a symmetry C18 column. Using a solvent gradient based on solvent A (orthophosphoric acid) and solvent B (methanol), the effluent was monitored at 250 nm with a 1.0 mL/min flow rate. The peaks of 11-KBA and A-11-KBA were eluted at 5.8 and 6.3 minutes, while those of Z and E-guggulsterone were at 4.8 and 5.3 minutes. For the HPTLC method of separation, a silica gel layer was applied on an aluminum plate prewashed in methanol using a Camag Linomat V applicator fitted with a 100 μL syringe. The linear expansion was carried out using a solvent mixture of n-hexane, chloroform, ethyl acetate, and methanol (v/v/v: 10:3:3:1, respectively). Camag T.L.C. scanner III (V 1.4.3.6336), operating in reflectance-absorbance mode at 254 nm and controlled by win CATS software, was used to carry out the densitometric scanning. The R.F. resolutions for 11-KBA, A-11-KBA, E-guggulsterone, and Z-guggulsterone in the selected mobile phase were 0.68, 0.61, 0.39, and 0.28, respectively. The linearity, accuracy, and precision of the techniques were all confirmed. The proposed methods were successful in estimating E- and Z-guggulsterone as well as 11-KBA and A-11-KBA.
SIZING PHOTOVOLTAIC SYSTEM IN DUHOK PROVINCE, KURDISTAN REGION OF IRAQ
Authors: KABAO FARHAN K. , Omar Omar S.
Published: July 2023

Using clean energy sources instead of traditional methods of energy production is important to tackle global warming and climate change. As in the rest cities of the Kurdistan Region and Iraq, the national electricity outage crisis continues in Duhok Governorate and the production of energy via different sources is still needed.
This paper studies the simulation of two different types of solar energy systems on school roofs using the Homer Pro software. The first is a grid-connected system and the second, is an off-grid system for six different regions of Duhok Governorate, using the solar radiation data for each site.
Our findings confirm the preference for on-grid PV over an off-grid PV system at all sites. As the cost of energy in USD per kWh in both grid-tied and stand-alone models varies from one region to another, which is as follows: Amedi (0.089, 0.339), Kani Masi (0.091, 0.0338), Bamarni (0.093, 0.338), Mangesh (0.095, 0.349), Semel (0.107, 0.341), and Akre (0.127, 0.347).
The net present cost NPC in both grid-connected and grid-independent for 160 kW PV systems is as follows: Kani Masi ($217303, $260504), Amedi ($217621, $260710), Bamarni ($219007, $260587), Mangesh ($220167, $261239), Semel ($227566, $261222), and finally Akre ($238671, $262203).
Faiz oranı, döviz kuru ve ekonomik büyümenin otomobil satışları üzerindeki etkisinin incelenmesi: Türkiye örneği
Authors: BATIRLIK Sema Nur , ZEREN Feyyaz , GENÇER Yasin Galip
Published: July 2023

Otomotiv sektörü; ekonomiye olan katkıları sebebiyle, gelişmiş ve gelişmekte olan ülkeler açısından büyük önem taşımaktadır. Mevcut çalışmada otomobil satışları ile; döviz kuru, taşıt kredisi faiz oranları ve ekonomik büyüme arasındaki ilişkinin açıklanması amaçlanmıştır. Bu doğrultuda 2011:1 – 2022:6 dönemi verileri zaman serisi yöntemleri kullanılarak analiz edilmiştir. Mevcut araştırmada birim kök sınaması ve nedenselliği test etmek adına Fourier ADF ve Fourier nedensellik yöntemlerinden faydalanılmıştır. Fourier ADF testi sonucunda; döviz kuru ve faiz oranı değerlerinin seviye düzeyinde birim kök içermediği ve anlamlı sonuçlar çıktığı sonucuna varılmıştır. Otomobil satışları ve ekonomik büyüme verilerinin ise birinci fark alındıktan sonra durağan hale geldikleri görülmüştür. Fourier Granger nedensellik testi sonuçları ele alındığında otomobil satışları ile ekonomik büyüme ve otomobil satışları ile faiz oranı arasında tek yönlü bir nedensellik ilişkisi olduğu sonucuna ulaşılmıştır. Bu bağlamda otomobil satışlarında ekonomik büyüme ve taşıt kredisi faiz oranına doğru bir nedensellik ilişkisinin söz konusu olduğunu söylemek mümkündür. Test sonuçları dikkate alındığında otomobil satışları ile faiz oranı arasında herhangi bir ilişkinin var olduğu görülmemişti. Elde edilen veriler ışığında otomobil satışlarının ekonomik büyüme ve taşıt kredisi faiz oranları üzerinde etkili olduğu fakat döviz kuru üzerinde herhangi bir etkisinin olmadığı söylenebilir.
Jacques Handschin and the First Post-War Meetings of the International Musicological Society (Based on the Scholar’s Correspondence)
Authors: Князева Ж.В.
Published: July 2023

Статья посвящена эпизоду из истории Международного музыковедческого общества (IMS). Она продолжает исследование эпистолярного наследия российско-швейцарского музыковеда и органиста Жака Гандшина (1886, Москва — 1955, Базель). С 1936 года ученый входил в директорию IMS. В 1948 и 1949 годах в Базеле прошли первые после войны международные собрания музыковедов: конференция директории и IV конгресс IMS. Обстановка в международных музыковедческих кругах была напряженная. Попытка повлиять на нежелательный с его точки зрения ход событий привела Гандшина к конфликту и выходу из директории. Данная статья представляет ряд неизвестных ранее эпистолярных источников. Эти документы позволяют изучить события по впечатлениям их непосредственных участников, различить драматизм происходившего, скрытый от официальных отчетов. Они также показывают, какие возможности восстановления международной научной работы в сложный период истории находили наши коллеги-предшественники, и с какими трудностями они сталкивались.

This article says about an episode in the history of the International Musicological Society (IMS). It continues my study of the corpus of letters of the Russian-Swiss musicologist and organist Jacques Handschin (1886, Moscow — 1955, Basel). From 1936, he was a member of the IMS Directory. In 1948 and 1949, Basel hosted the first international meetings of musicologists after the war: the Directory Conference and the 4th Congress of the IMS. The atmosphere in international musicological circles was tense. An attempt to influence the undesirable course of events led Handschin to conflict and resignation from the Directory. This article presents some previously unknown epistolary sources. These documents allow to study the events from the immediate experience of their participants. They also show what opportunities our predecessor colleagues found to re-establish international scientific work in a difficult period of history, and what difficulties they faced.
Nature of the amorphous-amorphous interfaces in solid-state batteries revealed using machine-learned interatomic potentials
Authors: Wang Chuhong , Aykol Muratahan , Mueller Tim
Published: July 2023

Non-crystalline solid materials have attracted growing attention in energy storage for their desirable properties such as ionic conductivity, stability and processability. However, compared to bulk crystalline materials, fundamental understanding of these highly complex metastable systems is hindered by the scale limitations of density functional theory (DFT) calculations and resolution limitations of experimental methods. To fill the knowledge gap and guide the rational design of amorphous battery materials and interfaces, we present a molecular dynamics (MD) framework based on machine-learned interatomic potentials trained on the fly to study the amorphous solid electrolyte Li3PS4 and its protective coating, amorphous Li3B11O18. The use of machine-learned potentials allows us to simulate the materials at time and length scales that are not accessible to DFT while maintaining a near-DFT level of accuracy. This approach allows us to calculate amorphization energies, amorphous-amorphous interface energies, and the impact of the interface on lithium ion conductivity. This study demonstrates the promising role of actively-learned interatomic potentials in extending the application of ab-initio modeling to more complex and realistic systems such as amorphous materials and interfaces.
What Does the Accuracy of the Equilibrium Dissociation Constant of Affinity Complexes Depend on Fundamentally?
Authors: Wang Tong , Ji Hongchen , Everton Daniel , Le An , Krylova Svetlana , Fournier René , Krylov Sergey
Published: July 2023

The equilibrium dissociation constant (Kd) characterizes stability of binding complexes. The classic way of Kd determination involves finding the dependence of a fraction of unbound ligand on the total concentration of target (T0) when the total concentration of ligand (L0) remains constant. It is known that Kd determination for highly stable complexes is notoriously inaccurate; however, what the accuracy of Kd depends on fundamentally, i.e., method-independently, is largely unknown. Here we present an error-propagation analysis that answers this question in detail. This analysis explains the critical importance of the L0/Kd value for the accuracy of Kd and allows one to define the range of L0/Kd values required for accurate Kd determination. Our analysis creates a theoretical foundation for improving the accuracy of Kd determination.
Rheumatoid factor: study history and concept evolution
Authors: Guliaev Sergei V. , Strizhakov Leonid A. , Moiseev Sergey V.
Published: July 2023

Rheumatoid factor became the first laboratory marker of rheumatoid arthritis and one of the first serological markers used to recognize the major autoimmune diseases. Details of the discovery with special regard to contribution of E. Waaler and H. Rose are presented in this historical review. Same assays used to exam the rheumatoid factor, its frequency and modern view on diagnostic significance in different diseases are described in this article.
Comparative assessment of sensitivity and specificity of three variants of classification criteria for systemic lupus erythematosus in a cohort of Russian patients
Authors: Reshetnyak Tatiana M. , Lisitsyna Tatiana A. , Cheldieva Fariza A. , Shumilova Anastasiia A. , Glukhova Svetlana I. , Starovoytova Mayya N. , Seredavkina Nataliya V. , Desinova Oxana V. , Verizhnikova Zhanna G. , Nasonov Evgeny L.
Published: July 2023

Background. The clinical and serologic heterogeneity of systemic lupus erythematosus (SLE) presents challenges for diagnosis, particularly in the earliest stages of the disease when there are insufficient signs to make a reliable diagnosis.
Aim. To make a comparative assessment of sensitivity and specificity of various classification criteria of SLE on a cohort of patients of Nasonova Research Institute of Rheumatology.
Materials and methods. A total of 252 patients were included in the study; 152 (60%) of 252 patients had reliable SLE (mean age 36 [29.546] years, duration of disease 9 [3.419] years). Of 252 patients, 26 (11%) had PAPS (mean age 36.5 [3142] years, duration of disease 4.6 [110.4] years). Systemic sclerosis was diagnosed in 74/252 (29%) patients, (mean age 51.5 [4259] years, duration of disease 9 [516] years). The quality of the classification function of the criteria was assessed by ROC analysis.
Results. SLE was diagnosed in 131 (86%) of 152 patients using the American College of Rheumatology ACR)-1997 criteria, in 145 (95%) using the The Systemic Lupus International Collaborating Clinics (SLICC) 2012 criteria, and in 144 (94.7%) using the European League Against Rheumatism (EULAR)/ACR 2019 criteria. ANF positivity was the least statistically significant of all signs in relation to the diagnosis of SLE. The area under the curve (AUC) for ANF1/160 titers was AUC 0.654 for the ACR-97 criteria, AUC 0.616 for the SLICC-12 SLE criteria, and AUC 0.609 for the 2019 EULAR/ACR criteria. ROC analysis of the relationship between the number of criteria/points and a reliable diagnosis of SLE revealed a high diagnostic accuracy the AUC for all SLE criteria was greater than 0.940. In the ROC analysis of patients with SLE and PAFS, indicating the number of diagnostic criteria, sensitivity was 86% for ACR-1997, 95% for SLICC-2012, 95% for EULAR/ACR 2019, and specificity was 100, 62 and 62%, respectively.
Conclusion. The classification criteria SLICC-2012 and EULAR/ACR 2019 are more sensitive for the diagnosis of SLE in the Russian population, and the criteria ACR-1997 are more specific. All three variants of the SLE classification criteria have sufficient sensitivity and specificity for their use in real clinical practice.