bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of CYP2C9 Polymorphisms on Plasma Concentration of Warfarin and
7-Hydroxy Warfarin in South Indian Patients
Authors: Kumar Dhakchinamoorthi Krishna , Uppugunduri Chakradhara Rao Satyanarayana , Shewade Deepak Gopal , Chandran B.V. Sai , Adithan Chandrasekaran
Published: November 2021

Background:

Warfarin is primarily metabolized by cytochrome P450 2C9 (CYP2C9) enzyme,
which is encoded by the CYP2C9 gene. CYP2C9*2 and CYP2C9*3 variants significantly influence warfarin
metabolism and subsequently the required dose of warfarin.

Objective:

The current retrospective study was aimed to determine the influence of CYP2C9 variants on
warfarin metabolic ratio (MR, warfarin/7-hydroxy warfarin) and warfarin maintenance therapy in 210 patients
(mean age 44.6±11.6 (SD) years; male to female ratio 81:129).

Method:

High-performance liquid chromatography (HPLC) with UV detector was used to measure plasma
concentrations of warfarin and 7-hydroxy warfarin. Plasma samples were collected 12 h after the previous dose
of warfarin was administered. CYP2C9 variants (rs1799853 and rs1057910) were identified using real-time
polymerase chain reaction allele-discrimination method.

Results:

The mean daily maintenance dose of warfarin was 4.6±1.8 (SD) mg. The mean plasma warfarin and
7-hydroxy warfarin concentrations were 3.7±1.6 (SD) μg/mL and 1.1±0.54 (SD) μg/mL, respectively. Patients
carrying other CYP2C9 variants required 39% lower warfarin maintenance dose (3.3±1.2 mg) than
CYP2C9*1*1 carrier (4.9±1.8 mg), (p<0.0001). MRs differed significantly between CYP2C9 variant carriers
(8.1±5.1) and normal genotype carriers (4.8±3.9) (p<0.0001). Probit analysis identified an MR value of 7.6 as
the anti-mode (sensitivity of 84% and specificity of 55%) to differentiate poor and intermediate metabolizers
(carriers of any *CYP2C9*2 or CYP2C9*3 variants) from normal metabolizers (CYP2C9*1*1 genotype).

Conclusion :

The present study results provide, insights on the effect of CYP2C9 genetic polymorphisms on
inter-individual variability in warfarin metabolism and emphasizes utility of phenotyping in a setting of
genotype-guided dosing of warfarin in South Indian population.
Electron Microscopic and Pathological Changes in Lung Cancer after
Intratumoral Injection of Sodium Bicarbonate
Authors: Rahman Manar A.A. , Arram Eman O. , Elhadidy Tamer , Hassan Mahmoud A.E. , Habashy Hany O. , El Badrawy Mohammad K.
Published: November 2021

Background:

Lung cancer can be treated with surgery, chemotherapy, radiation therapy,
targeted therapy, and palliative care. Palliative therapy is applied for inoperable lung cancer as it induces
tumour necrosis. PH of tumour tissue is acidic; application of sodium bicarbonate (SB) into
lung cancer locally via bronchoscopy can change its core pH, which may lead to tumour destruction.
We aimed to study the ultrastructural characteristics of lung cancer and assess the destructive
effects of sodium bicarbonate 8.4 % local injection on tumour tissue integrity by light and electron
microscopies.

Methods:

This study was conducted on 21 patients with central bronchial carcinoma diagnosed according
to WHO classification 2015. Three bronchoscopic biopsies were taken; two biopsies before
and one after injection of sodium bicarbonate 8.4 % solution of 20 ml via transbronchial needle.
All biopsies were examined by both light and electron microscopes. The first biopsy was examined
to diagnose the tumour morphologically with and without immunostaining. Second and
third biopsies were taken before and after SB 8.4 % injection to compare pathological changes in
tumour tissue integrity as well as cellular ultra-structures. Different lung cancer pathological types
were included in the study.

Results:

Tumour tissue integrity and pathological changes were examined in biopsies before and after
injection of sodium bicarbonate 8.4 %. Extensive necrosis in all cell types of lung cancer was
seen after injection of SB; this important finding was delineated by both light and electron microscopies.

Conclusion:

Preliminary ultrastructural study of small biopsy of lung tumors has a complementary
role in both morphological and immunohistochemical studies. Local injection of sodium bicarbonate
into lung cancer induces extensive necrosis that may reflect its important therapeutic role in
lung cancer.
Predicting Sepsis in the Intensive Care Unit (ICU) through Vital Signs using Support Vector Machine (SVM)
Authors: Rayan Zeina , Alfonse Marco , Salem Abdel-Badeeh M.
Published: November 2021

Background:

As sepsis is one of the life-threatening diseases, predicting sepsis with high accuracy could help save lives.

Methods:

Efficiency and accuracy of predicting sepsis can be enhanced through optimal feature selection. In this work, a support vector machine model is proposed to automatically predict a patient’s risk of sepsis based on physiological data collected from the ICU.

Results:

The support vector machine algorithm that uses the extracted features has a great impact on sepsis prediction, which yields the accuracy of 0.73.

Conclusion:

Predicting sepsis can be accurately performed using the main vital signs and support vector machine.
Natural Products for Targeting Acanthamoeba spp.
Authors: Wehelie Yassmin Isse , Nasih Aishath Leesha , Anwar Ayaz , Siddiqui Ruqaiyyah , Maciver Sutherland , Khan Naveed Ahmed
Published: November 2021

:

Pathogenic Acanthamoeba is responsible for causing serious eye and fatal brain infections.
A successful prognosis remains elusive despite advances in chemotherapeutics and supportive
care. Natural products of medicinal value remain a promising source for drug development due
to their broad-spectrum antimicrobial activities. Herein, we discuss anti-Acanthamoebic properties
of natural products originating from plants, marine, and microbial sources that could be exploited
as a potential avenue for drug discovery against infections caused by Acanthamoeba.
Cerebellum, GABA and Ataxia
Authors: Lalonde Robert , Strazielle Catherine
Published: November 2021

:

Various clinical results are obtained regarding the effects of cerebellar GABA transmission
on spinocerebellar ataxias. Based on animal studies, it is proposed that balanced GABAergic
transmission between GABA and other neurotransmitters such as glutamate may lead to more
promising results in treating such conditions.
Politeness	and Speech Acts	of Malay Kupang
Authors: Menno Vera Riyanti
Published: November 2021

The study was aimed at examining the use of polite language (language use) in Kupang Malay speech community. There are two basic theories of this research; speech act and linguistic politeness theory. The politeness theory was combined with speech act theory, because the speech act theory investigates what to choose, while the theory of politeness investigate whether the utterances are polite or not. In speech, the BMK speaker also uses the six the principles of politeness toward the listeners. These principles are tact maxim, generosity maxim, approbation maxim, modesty maxim, agreement maxim, and sympathy maxim
Educational Value in Erpangir Ku Lau Ritual with Gendang Lima Sendalanen
Authors: Hasintongan Ananta Prima
Published: November 2021

This study was aimed at determining the Ritual Process in terms of the meaning and value contained in the Erpangir Ku Lau Ritual Ceremony and the presentation of the ethnic context of Gendang Lima Sendalanen, Batak Karo Ethnic. This type of research was descriptive qualitative with an ethnographic approach. This study was carried out in Semangat Gunung Village, Karo, North Sumatra. The informants of this study were Artists and Lecturers of Karo Batak traditional music at Medan State University, while the object of the research was Erpangir Ku Lau Ritual ceremony along with the accompaniment of the music of Gendang Lima Sendalanen. The data sources in this study were obtained through observation and documentation. The analysis technique consisted of data reduction and conclusions. The results showed that this Ceremony contained the meaning and value of Social and Cultural Education and Multicultural which were reflected in the lyrics of Oral Literature from the spells in ritual ceremonies hummed in a ritual song namely Mangmang which has the meaning of respecting the ancestors and purification of things things that are not good while the value of education in rituals is reflected in the effort to maintain the cultural heritage of the Erpangir Ku Lau ritual ceremony.Keywords: educational value, Ritual Erpangir Ku Lau, Gendang Lima Sendalanen
ANALISIS SEMIOTIK DALAM CERPEN “TAK ADA YANG GILA DI KOTA INI”
Authors: Latifah Hani
Published: November 2021

Karya-karya sastra umumnya memiliki tanda atau simbol yang merepresentasikan makna tertentu yang perlu dipecahkan. Artikel ini bertujuan untuk memaparkan telaah kode-kode yang terdapat dalam cerpen “Tak Ada yang Gila di Kota Ini” karya Eka Kurniawan dengan menggunakan analisis semiotik yang dikemukakan oleh Roland Barthes yang mencakup beberapa sistem kode yaitu kode aksi, kode teka-teki, kode budaya, kode konotatif, dan kode simbolik. Metode yang digunakan dalam penelitian ini adalah metode penelitian deskriptif kualitatif. Data diperoleh dengan mengaplikasikan teknik baca dan catat. Data berupa, kata, frasa, klausa, dan atau kalimat. Hasil analisis menunjukkan bahwa kelima kode digunakan dalam cerpen diatas. Ada delapan bagian yang merepresentasikan kode aksi. Sementara itu, kode teka-teki digunakan untuk menggambarkan salah satu tokoh. Kode budaya digunakan untuk menggambarkan nilai-nilai yang dianut dan dipercayai para tokoh dalam cerpen. Dan dua kode terakhir yaitu kode konotatif dan simbolik, merupakan dua kode yang saling melengkapi satu sama lain, dimana kode konotatif menyiratkan suatu makna tertentu yang kemudian di di dalam novel tersebut direpresentasikan dalam bentuk symbol-simbol. A SEMIOTIC ANALYSIS OF THE SHORT STORY ENTITLED “NOTHING IS CRAZY IN THIS CITY”Literary works generally decode signs or symbols that represent certain meanings which need to be interpretated. This study reported the analysis of codes contained in the short story entitled “Nothing is Crazy in This City” written by Eka Kurniawan using a semiotic analysis proposed by Roland Barthes which comprised several code systems, namely code of action, code of puzzle, code of culture, connotative code, and symbolic code. The method used in this research was descriptive qualitative research method. The data were obtained by applying reading and note-taking techniques. Data were in the form of words, phrases, clauses, and or sentences. The analysis results showed that the five codes were all used in the short story. Within the story code of actions could be found in eight sections. Meanwhile, a puzzle code was used to describe one of the characters. Cultural codes were used to describe the values upheld and believed by the characters. Lastly, the connotative and symbolic codes were the two codes that complemented each other. The connotative codes implied certain meanings which were then represented in the form of symbols within the short story.
Persepsi dan pengembangan peta kognitif mahasiswa dalam blended learning
Authors: Mumpuniarti Mumpuniarti
Published: November 2021

Tujuan dari artikel ini adalah untuk merefleksikan manfaat perkuliahaan perkembangan anak berkebutuhan khusus melalui perkuliahaan blended learning dari aspek persepsi secara kuantitatif dan peningkatan peta kognitif secara kualitatif. Metode penelitian dengan angket dari respon mahasiswa secara kuantitatif, sedangkan peta kognitif diambil secara kualitatif terhadap fakta refleksi mahasiswa dalam mendalami materi kuliah. Respon angket meliputi sangat sesuai, sesuai, dan tidak sesuai terhadap komponen-komponen substansi perkuliahaan. Analisis data menggunakan persentase bagi data kuantitatif dan kategorial peta kognitif pada data kualitatif. Hasil diperoleh bahwa pada waktu kuantitatif persepsi mahasiswa dalam kondisi stabil, namun fakta peta kognitif secara kualitatif terjadi perubahan meningkat secara bervariasi. Dari sebelas mahasiswa peserta kuliah perkembangan anak berkebutuhan khusus ketika respon terhadap kesesuaian materi kuliah dengan capaian pembelajaran sebelum dam sesudah blended learning ternyata stabil. Peningkatan peta kognitif pada refleksi materi perkuliahaan sebelum dan sesudah blended learning bervariasi tergantung minat dan ketertarikan mahasiswa pada masing-masing komponen dari substansi perkuliahaan. Jadi, mata kuliah perkembangan anak berkebutuhan khusus bermanfaat bagi pencapaian profil lulusan.Perception and development of cognitive map's student through blended learningAbstractThe purpose of the article reflects the benefits of lecturing on the development of children with special needs through blended learning from quantitative aspects of perception and improving cognitive maps qualitatively. The research method with a questionnaire from the students' responses quantitatively, while the cognitive map is taken qualitatively to the fact of student reflection in studying lecture material. The questionnaire response includes very suitable, appropriate, and incompatible with the components of the lecture substance. Next, they were asked to reflect descriptively about the contents of the material in each lecture component. Data analysis uses percentages for quantitative and categorical cognitive map data on qualitative data. The results obtained that in quantitative time the perceptions of students are in a stable condition, but the facts of cognitive maps qualitatively change changes vary. Of the 11 (eleven) students participating in the development of children with special needs when the response to the suitability of the course material with learning outcomes before the dam after blended learning turned out to be stable. Increasing cognitive maps on reflection of lecture material before and after blended learning varies depending on student interest and interest in each component of the lecture substance. So, the developmental course of children with special needs is useful for achieving graduate profiles.
PEMBELAJARAN TEKNOLOGI INFORMASI DAN KOMUNIKASI DITINJAU DARI MINAT BELAJAR
Authors: Fauziyah Syifa , Triyono Mochamad Bruri
Published: November 2021

Penelitian ini bertujuan untuk mengetahui minat belajar pada saat pembelajaran teknologi informasi dan komunikasi khususnya siswa kelas X SMK ditinjau dari minat internal,minat eksternal, dan pendekatan belajar. Subjek pada penelitian ini adalah semua siswa kelas X Program Keahlian Teknik Komputer dan Jaringan di SMK Negeri 3 Yogyakarta yang berjumlah 30 siswa. Data penelitian dianalisis dengan statistik deskriptif, sedangkan metode yang digunakan untuk mengumpulkan data dalam penelitian ini menggunakan angket modifikasi skala likert. Dari hasil penelitian menunjukkan bahawa pertama, pembelajaran teknologi informasi dan komunikasi sudah dilaksanakan tetapi terdapat kendala yaitu guru mengajar hanya sebatas teori. Kedua, sebagian besar siswa memiliki minat belajar dengan kategori sedang dalam pembelajaran teknologi informasi dan komunikasi. Dengan demikian, minat belajar pada pembelajaran teknologi informasi dan komunikasi perlu ditingkatkan lagi. Ketiga peningkatan minat belajar pada pembelajaran teknologi informasi dan komunikasi dapat dilakukan dengan memadukan model pembelajaran yang sesuai sehingga siswa dapat menguasai materi baik teori ataupun praktik.INFORMATION AND COMMUNICATION TECHNOLOGY LEARNING REVIEWED FROM INTEREST TO LEARNThis study was aimed at determining the interest in learning information and communication technology of grade X vocational students in terms of internal interests, external interests, and learning approaches. The subjects in this study were 30 students of class X Computer and Network Engineering Skills Program at Vocational High School 3 of Yogyakarta. The research data were analyzed using descriptive statistics, while the method used to collect the data in this study was using a Likert scale modified questionnaire. The findings show that first, learning information and communication technology has been implemented but the teacher teaches only focus on the theory. Second, most students have an interest in learning with the moderate category in learning information and communication technology. Thus, interest in learning in learning information and communication technology needs to be increased. Third, increasing interest in learning in learning information and communication technology can be done by combining appropriate learning models so that students are able to master learning material both theory and practice.
NILAI NILAI KEARIFAN LOKAL SEBAGAI PEMBENTUK KARAKTER MASYARAKAT
Authors: Mazid Sukron , Prasetyo Danang , Farikah Farikah
Published: November 2021

Penelitian ini bertujuan untuk mengetahui kandungan nilai-nilai kearifan lokal yang hidup di masyarakat sehingga mampu menjadi pedoman hidup dalam membentuk karakter masyarakat setempat. Tulisan in merupakan penelitian deskriptif  kualitatif. Penelitian dilaksanakan di Magelang Raya yang terdiri dari Kota Magelang dan Kabupaten Magelang dari Bulan Mei sampai dengan Bulan Agustus 2020. Subjek penelitian ditentukan dengan cara  purposive, yakni tokoh-tokoh yang peham tentang kondisi masyarakat dan lingkungan Magelang. Hasil penelitian ini menemukan adanya nilai-nilai kearifan lokal yang mampu membentuk karakter masyarakat Magelang Raya. Kearifan lokal tersebut terdiri dari: (1) unsur sosial masyarakat dengan adanya pondok atau masyarakat pesantren sehingga memberikan corak masyarakat yang religius dan patuh terhadap pemimpinnya, akademi militer yang mampu memberikan teladan karakter yang tanggung jawab, disiplin, patriotik, semangat kebangsaan; (2) unsur keberadaan situs sejarah Candi Borobudur yang membentuk masyarakat memiliki karakter toleransi untuk tetap menjaga keharmonisan dalam keberagaman; (3) unsur budaya atau kesenian musik Gejog Lesung yang sarat akan pesan moral untuk bersama dalam keberagaman dan berbeda dalam kebersamaan; (4) unsur alam dengan adanya Gunung Tidar yang memiliki banyak prasasti dengan tulisan Aksara Jawa yang mengandung falsafah hidup sarat akan pesan moral untuk membentuk karakter jujur, bertanggung jawab, rendah hati, saling tolong menolong, dan menghindari kekerasan dalam setiap penyelesaian masalah dalam kehidupan.
Design of trainer kit as a fault-finding based on electricity and electronics learning media
Authors: Anwar Muhammad , Triyono Mochamad Bruri , Ta'ali Ta'ali , Hidayat Hendra , Syahputeri Veva Nellone
Published: November 2021

According to the field of expertise, efforts to strengthen the competence of graduates continue to be pursued, especially through optimizing the learning process. Among these efforts is to use learning media that strengthen the competence of the field of study and about thinking skills. This study aims to produce a trainer kit as a medium for learning basic electricity and electronics based on fault-finding in Basic Electrical and Electronics subjects. The method used is the Richey and Klein Design and Development (DD) method which consists of three stages, including planning (design), production, and evaluation. Experts carried out the assessment of the feasibility of the trainer kit with an instrument in the form of a questionnaire. The results of this study indicate that the trainer kit has a good performance.According to the field of expertise, efforts to strengthen the competence of graduates continue to be pursued, especially through optimizing the learning process. Among these efforts is to use learning media that strengthen the competence of the field of study and about thinking skills. This study aims to produce a trainer kit as a medium for learning basic electricity and electronics based on fault-finding in Basic Electrical and Electronics subjects. The method used is the Richey and Klein Design and Development (DD) method which consists of three stages, including planning (design), production, and evaluation. Experts carried out the assessment of the feasibility of the trainer kit with an instrument in the form of a questionnaire. The results of this study indicate that the trainer kit has a good performance.
Рост концентрации носителей заряда в тонких пленках висмута
Authors: Демидов Е.В. , Грабов В.М. , Комаров В.А. , Суслов А.В. , Герега В.А. , Крушельницкий А.Н.
Published: November 2021

The reasons for increasing the charge carriers concentration in thin bismuth films are discussed. The concentration was calculated on the basis of the measured electrical and galvanomagnetic coefficients at the temperature 77K under the two-band approximation and the assumption that the charge carriers free path in the film is isotropic.
Efficient Debye Function Interpolation Formulae: Sample Applications to Diamond
Authors:   Technische Universität Chemnitz, Institut für Physik, D-09107 Chemnitz, Germany, Pässler Roland
Published: November 2021

The well-known classical heat capacity model developed by Debye proposed an approximate description of the temperature-dependence of heat capacities of solids in terms of a characteristic integral, the T-dependent values of which are parameterized by the Debye temperature, Θ D . However, numerous tests of this simple model have shown that within Debye’s original supposition of approximately constant, material-specific Debye temperature, it has little chance to be applicable to a larger variety of non-metals, except for a few wide-band-gap materials such as diamond or cubic boron nitride, which are characterized by an unusually low degree of phonon dispersion. In this study, we present a variety of structurally simple, unprecedented algebraic expressions for the high-temperature behavior of Debye’s conventional heat-capacity integral, which provide fine numerical descriptions of the isochoric (harmonic) heat capacity dependences parameterized by a fixed Debye temperature. The present sample application of an appropriate high-to-low temperature interpolation formula to the isobaric heat capacity data for diamond measured by Desnoyers and Morrison [17], Victor [24], and Dinsdale [25] provided a fine numerical simulation of data within a range of 200 to 600 K, involving a fixed Debye temperature of about 1855 K. Representing the monotonically increasing difference of the isobaric versus isochoric heat capacities by two associated anharmonicity coefficients, we were able to extend the accurate fit of the given heat capacity ( C p ( T ) ) data up to 5000 K. Furthermore, we have performed a high-accuracy fit of the whole C p ( T ) dataset, from approximately 20 K to 5000 K, on the basis of a previously developed hybrid model, which is based on two continuous low-T curve sections in combination with three discrete (Einstein) phonon energy peaks. The two theoretical alternative curves for the C p ( T ) dependence of diamond were found to be almost indistinguishable throughout the interval from 200 K to 5000 K.
mHealth Intervention to Improve Treatment Outcomes Among People With HIV Who Use Cocaine: Protocol for a Pilot Randomized Controlled Trial
Authors: Ranjit Yerina S , Krishnan Archana , Ghosh Debarchana , Cravero Claire , Zhou Xin , Altice Frederick L
Published: November 2021

Background

Antiretroviral therapy is effective in reducing HIV-related morbidity, mortality, and transmission among people with HIV. However, adherence and persistence to antiretroviral therapy are crucial for successful HIV treatment outcomes. People with HIV who use cocaine have poor access to HIV services and lower retention in care.

Objective

The primary goal of this paper is to provide a detailed description of a mobile health intervention. This study is designed to improve medication adherence among people with HIV who use cocaine. A secondary goal is to list the important challenges and adaptations incorporated in the study design.

Methods

This study, titled Project SMART, used a wireless technology–based intervention, including cellular-enabled electronic pillboxes called TowerView Health and smartphones, to provide reminders and feedback on adherence behavior. The intervention design was based on the theoretical frameworks provided by the self-determination theory and the Motivation Technology Model. The 12-week pilot randomized controlled trial with four arms provided three types of feedback: automated feedback, automated+clinician feedback, and automated feedback+social network feedback.

Results

The study was funded by the National Institute of Drug Abuse (R21DA039842) on August 1, 2016. The institutional review board for the study was approved by Yale University on March 21, 2017. Data collection lasted from June 2017 to January 2020. The final enrollment was 71 participants, of whom 57 (80%) completed the study. The data are currently undergoing analysis, and the manuscript is being developed for publication in early 2022.

Conclusions

Implementing complex mobile health interventions for high-risk and marginalized populations with multicomponent interventions poses certain challenges, such as finding companies with adequate technology for clients and financial stability and minimizing the research-related burden for the study population. Conducting feasibility studies is important to recognize these challenges and the opportunity to address these challenges with solutions while keeping the design of a randomized controlled trial as true as possible.

Trial Registration

Clinicaltrials.gov NCT04418076; https://clinicaltrials.gov/ct2/show/NCT04418076

International Registered Report Identifier (IRRID)

DERR1-10.2196/28332
Human-Centered Design of Mobile Health Apps for Older Adults: Systematic Review and Narrative Synthesis
Authors: Nimmanterdwong Zethapong , Boonviriya Suchaya , Tangkijvanich Pisit
Published: November 2021

Background

The world is aging. The number of older patients is on the rise, and along with it comes the burden of noncommunicable diseases, both clinical and economic. Attempts with mobile health (mHealth) have been made to remedy the situation with promising outcomes. Researchers have adopted human-centered design (HCD) in mHealth creation to ensure those promises become a reality.

Objective

This systematic review aims to explore existing literature on relevant primary research and case studies to (1) illustrate how HCD can be used to create mHealth solutions for older adults and (2) summarize the overall process with recommendations specific to the older population.

Methods

We conducted a systematic review to address the study objectives. IEEE Xplore, Medline via Ovid, PubMed, and Scopus were searched for HCD research of mHealth solutions for older adults. Two independent reviewers then included the papers if they (1) were written in English, (2) included participants equal to or older than 60 years old, (3) were primary research, and (4) reported about mHealth apps and their HCD developments from start to finish. The 2 reviewers continued to assess the included studies’ qualities using the Mixed Methods Appraisal Tool (MMAT). A narrative synthesis was then carried out and completed.

Results

Eight studies passed the eligibility criteria: 5 were mixed methods studies and 3 were case studies. Some studies were about the same mHealth projects with a total of 5 mHealth apps. The included studies differed in HCD goals, target groups, and details of their HCD methodologies. The HCD process was explored through narrative synthesis in 4 steps according to the International Standardization Organization (ISO) standard 9241-210: (1) understand and specify the context of use, (2) specify the user requirements, (3) produce design solutions to meet these requirements, and (4) evaluate the designs against requirements. The overall process and recommendations unique to older adults are summarized logically with structural order and time order based on the Minto pyramid principle and ISO 9241-210.

Conclusions

Findings show that HCD can be used to create mHealth solutions for older adults with positive outcomes. This review has also summarized practical HCD steps and additional suggestions based on existing literature in the subfield. However, evidence-based results are still limited because most included studies lacked details about their sampling methods and did not set objective and quantifiable goals, leading to failure to draw significant conclusions. More studies of HCD application on mHealth for older adults with measurable design goals and rigorous research strategy are warranted.
A Telemedicine-Guided Self-Collection Approach for PCR-Based SARS-CoV-2 Testing: Comparative Study
Authors: Würstle Silvia , Erber Johanna , Hanselmann Michael , Hoffmann Dieter , Werfel Stanislas , Hering Svenja , Weidlich Simon , Schneider Jochen , Franke Ralf , Maier Michael , Henkel Andreas G , Schmid Roland M , Protzer Ulrike , Laxy Michael , Spinner Christoph D
Published: November 2021

Background

Large-scale, polymerase chain reaction (PCR)-based SARS-CoV-2 testing is expensive, resource intensive, and time consuming. A self-collection approach is a probable alternative; however, its feasibility, cost, and ability to prevent infections need to be evaluated.

Objective

This study aims to compare an innovative self-collection approach with a regular SARS-CoV-2 testing strategy in a large European industrial manufacturing site.

Methods

The feasibility of a telemedicine-guided PCR-based self-collection approach was assessed for 150 employees (intervention group) and compared with a regular SARS-CoV-2 testing approach used for 143 employees (control group). Acceptance, ergonomics, and efficacy were evaluated using a software application. A simulation model was implemented to evaluate the effectiveness. An interactive R shiny app was created to enable customized simulations.

Results

The test results were successfully communicated to and interpreted without uncertainty by 76% (114/150) and 76.9% (110/143) of the participants in the intervention and control groups, respectively (P=.96). The ratings for acceptability, ergonomics, and efficacy among intervention group participants were noninferior when compared to those among control group participants (acceptability: 71.6% vs 37.6%; ergonomics: 88.1% vs 74.5%; efficacy: 86.4% vs 77.5%). The self-collection approach was found to be less time consuming (23 min vs 38 min; P<.001). The simulation model indicated that both testing approaches reduce the risk of infection, and the self-collection approach tends to be slightly less effective owing to its lower sensitivity.

Conclusions

The self-collection approach for SARS-CoV-2 diagnosis was found to be technically feasible and well rated in terms of acceptance, ergonomics, and efficacy. The simulation model facilitates the evaluation of test effectiveness; nonetheless, considering context specificity, appropriate adaptation by companies is required.
Неврологічні порушення в пацієнтів, які перенесли COVID-19: як лікувати в умовах пандемії
Authors: Mishchenko T.S. , Mishchenko V.M. , Sokolik V.V. , Fisenko A.V. , Zdesenko I.V.
Published: November 2021

У статті подано огляд даних світової літератури стосовно уражень нервової системи в пацієнтів, які перенесли COVID-19. Також наведені результати власного відкритого порівняльного дослідження ефективності комплексного застосування Ксаврону, Тіворелю й Ксилату в пацієнтів з неврологічними порушеннями в постковідному періоді. Був продемонстрований позитивний вплив вищезазначеного комплексу препаратів на когнітивні функції, що виражалось в збільшенні темпу психічної діяльності, покращанні короткочасної і оперативної пам’яті, підвищенні стійкості психічних процесів і зниженні рівнів реактивної та особистісної тривожності.
РАСЧЕТ ЧУВСТВИТЕЛЬНОСТИ ТОНКОПЛЕНОЧНЫХ МАГНИТОРЕЗИСТИВНЫХ СЕНСОРОВ УГЛА ПОВОРОТА ДЛЯ РОБОТИЗИРОВАННОЙ УМНОЙ ПЕРЧАТКИ
Authors: Глаголев П.Ю. , Демин Г.Д. , Чиненков М.Ю. , Дюжев Н.А.
Published: November 2021

С применением микромагнитного моделирования проведены численные расчеты чувствительности анизотропных магниторезистивных сенсоров для различных типов топологий двухмостовой схемы чувствительного элемента. Также проведен анализ распределения магнитного поля вблизи месторасположения сенсоров на перчатке. Рассчитан линейный отклик выходного сигнала к углу поворота магнитного поля и предложены возможные способы улучшения параметров магниторезистивных структур применительно к детектированию диапазона углов до 0,5°.
ВЫДЕЛЕНИЕ НЕМАРКОВСКОЙ КОМПОНЕНТЫ КВАНТОВОЙ ДИНАМИКИ В ПСЕВДОСТОХАСТИЧЕСКОМ ПРЕДСТАВЛЕНИИ
Authors: Киктенко Е.О. , Яшин В.И. , Мастюкова А.С. , Мастюкова А.К.
Published: November 2021

Рассматривается вопрос о количественном описании немарковости квантового процесса по его псевдостохастической матрице в вероятностном представлении квантовых состояний на основе информационно-полных измерений. Предлагается подход к оценке немарковской компоненты в исследуемой динамике.
ИССЛЕДОВАНИЕ ПОТЕРЬ СВЧ-СИГНАЛА В ЛИНИЯХ ПЕРЕДАЧ НА ОСНОВЕ ГЕТЕРОСТРУКТУРЫ ALGAN/ GAN НА КРЕМНИИ
Authors: Ромодин М.С. , Баранов Г.В. , Дорофеев А.А. , Панасенко П.В. , Царев А.В.
Published: November 2021

В работе предложена методика оценки потерь СВЧ-сигнала в линиях передач на структурах, предназначенных для создания GaN/Si СВЧ МИС. Экспериментальными методами проведена верификация результатов трехмерного электромагнитного моделирования потерь СВЧ-сигнала.
ГИБКАЯ БУСТЕРНАЯ RFID-МЕТКА СВЧ-ДИАПАЗОНА С ИНДУКТИВНОЙ СВЯЗЬЮ
Authors: Помелов Н.В. , Резник А.Ю.
Published: November 2021

В работе представлены конструкции бустерных антенн с индуктивной связью, описан принцип работы, приведены результаты измерений дальности считывания опытных образцов меток описанной конструкции.
ИНТЕЛЛЕКТУАЛЬНАЯ СИСТЕМА АНАЛИЗА И ОЦЕНКИ МЕДИЦИНСКИХ ИЗОБРАЖЕНИЙ ДЛЯ ПОДДЕРЖКИ ПРИНЯТИЯ ВРАЧЕБНЫХ РЕШЕНИЙ
Authors: Бурдин Д.В. , Руденко М.А.
Published: November 2021

В статье представлена разработка системы анализа и оценки медицинских изображений с использованием искусственных нейронных сетей. Созданная система позволяет проводить классификацию изображений для диагностики диабетической микроангиопатии.
РАЗРАБОТКА УСТАНОВКИ ДЛЯ ИЗМЕРЕНИЯ ПРОФИЛЕЙ ПРИМЕСЕЙ В ПОЛУПРОВОДНИКАХ МЕТОДОМ ДВУХЗОНДОВОГО ИЗМЕРЕНИЯ СОПРОТИВЛЕНИЯ РАСТЕКАНИЯ
Authors: Краснов А.В. , Ефанов М.В. , Оленников Ф.Е.
Published: November 2021

В работе описан экспериментальный образец установки для измерения профилей примесей в полупроводниках, приведен метод измерения сопротивления растекания с использованием двух зондов.
ИССЛЕДОВАНИЕ БАРЬЕРНЫХ СЛОЕВ ДЛЯ ФОРМИРОВАНИЯ МЕДНЫХ КОНТАКТОВ К ТРАНЗИСТОРНОЙ СТРУКТУРЕ
Authors: Горохов С.А. , Патюков С.И. , Плаксин В.Г.
Published: November 2021

В работе исследуются возможные барьерные слои (Ti / TiN / Ti, Ti / TiN / Ta, TaN/Ta) для формирования контактных окон к транзисторным структурам из меди.
ИЗУЧЕНИЕ ВЛИЯНИЯ ДИСПЕРСИОННОЙ СРЕДЫ НА ПРОЦЕСС ЖИДКОФАЗНОЙ ЭКСФОЛИАЦИИ ДВУМЕРНЫХ НАНОКРИСТАЛЛОВ BI2TE3 ДЛЯ ИСПОЛЬЗОВАНИЯ В ДАТЧИКАХ ИК-ДИАПАЗОНА СПЕКТРА
Authors: Лаврентьев Н.А. , Мирофянченко А.Е. , Мирофянченко Е.В. , Попов В.С.
Published: November 2021

В работе исследовался процесс получения двумерных нанокристаллов теллурида висмута (Bi2Te3) для использования в датчиках короткого и среднего ИК-диапазона. Были получены образцы в различных дисперсионных средах и при разных режимах жидкостной эксфолиации. Нанокристаллы оценивались разными методами. Получены зависимости спектров поглощения материала, показывающие возможность направленного изменения спектральных характеристик.
ФУНДАМЕНТАЛЬНЫЕ ФИЗИЧЕСКИЕ ОГРАНИЧЕНИЯ И ПЕРСПЕКТИВЫ РАЗВИТИЯ НАНОЭЛЕКТРОНИКИ
Authors: Арутюнов К.Ю.
Published: November 2021

Представлен обзор основных причин, ограничивающих миниатюризацию наноэлектронных систем. В элементах сверхмалых размеров, построенных с использованием стандартной металлической и полупроводниковой технологии, различные эффекты фундаментального характера приводят к нарушению штатного режима работы. Приводятся примеры сверхпроводящих наноэлектронных устройств.
OWNERSHIP STRUCTURE AND FINANCIAL PERFORMANCE OF MANUFACTURING FIRMS IN SUB-SAHARAN AFRICA
Authors: Ajao Mayowa Gabriel , Ejokehuma Jude Osazuwa
Published: November 2021

This study investigates the effect of ownership structure on the financial performance of listed manufacturing firms in three Sub-Saharan Africa countries (Nigeria, Kenya and South–Africa) based on the critical mass indices of their respective bourse. Relevant data from the financial reports of sampled firms were analyzed using the co-integration test and the system-GMM for a period 2010-2019 using Return on Asset, and Tobin-Q as dependent variables while government ownership, block ownership and institutional ownership concentrations were explanatory variables. The empirical results revealed that all the explanatory variables have significant effect on the performance indicators (ROA, TOBIN Q). The result of robustness checks also revealed that both government and institutional ownership concentrations have predominately negative effect on financial performance for the respective countries while block ownership concentration is largely positive for most of the manufacturing firms. The study recommends that policy makers should create favorable policies to encourage balanced investment from all categories of investors and ensure only few owners who have the wherewithal to diversify and attract skills and competencies to improve firm performance. Government should also retain some ownership in foreign and local firms to enhance shareholders’ confidence
PARALLELISM OF DISTRIBUTIONS AND GEODESICS ON F(±a2; ±b2)-STRUCTURE LAGRANGIAN MANIFOLD
Authors: Khan Mohammad Nazrul Islam , Das Lovejoy S.
Published: November 2021

This paper deals with the Lagrange vertical structure on the vertical space TV (E) endowed with a non null (1,1) tensor field FV satisfying (Fv2-a2)(Fv2+a2)(Fv2 - b2)(Fv2 + b2) = 0. In this paper, the authors have proved that if an almost product structure P on the tangent space of a 2n-dimensional Lagrange manifold E is defined and the F(±a2; ±b2)-structure on the vertical tangent space TV (E) is given, then it is possible to define the similar structure on the horizontal subspace TH(E) and also on T(E). In the next section, we have proved some theorems and have obtained conditions under which the distribution L and M are r-parallel, r¯ anti half parallel when r = r¯ . The last section is devoted to proving theorems on geodesics on the Lagrange manifold
THE STATISTICAL MULTIPLICATIVE ORDER CONVERGENCE IN RIESZ ALGEBRAS
Authors: Aydın Abdullah
Published: November 2021

The statistically multiplicative convergence in Riesz algebras was studied and investigated with respect to the solid topology. In the present paper, the statistical convergence with the multiplication in Riesz algebras is introduced by developing topology-free techniques using the order convergence in vector lattices. Moreover, we give some relations with the other kinds of convergences such as the order statistical convergence, the $mo$-convergence, and the order convergence.
$D_a$-HOMOTHETIC DEFORMATION AND RICCI SOLITIONS IN THREE DIMENSIONAL QUASI-SASAKIAN MANIFOLDS
Authors: Mandal Tarak
Published: November 2021

In the present paper, we have studied curvature tensors of a quasi-Sasakian manifold with respect to the $D_a$-homothetic deformation. We have deduced the Ricci solition in quasi-Sasakian manifold with respect to the $D_a$-homothetic deformation. We have also proved that the quasi-Sasakian manifold is not $\bar{\xi}$-projectively flat under $D_a$-homothetic deformation. Also we give an example to prove the existance of quasi-Sasakian manifold.
Three Cases of Insomnia in Herniated Intervertebral Disk Patients Treated with Uhwangchungsim-won
Authors: Bae Ji-eun , Choi Gyu-cheol , Park Jae-won , Kim Dong-jin , Hong Jeong-su , Kim Su-jin , Kyung Da-hyun , Huh Hyo-seung , Kim Min-kyung
Published: November 2021

Objective: This study examined a case in which insomnia and pain due to herniated intervertebral disks were improved by treatment with an oriental herbal and the administration of Uhwangchungsim-won.Case Summary: Three patients with insomnia diagnosed with herniated intervertebral disks were treated with a series of Korean medical therapies, including the herbal medication Uhwangchungsim-won, acupuncture, herbal acupuncture, and physical therapy. We used the Numerical Rating Scale (NRS) to measure subjective sleep states and the European Quality of Life Five Dimensions (EQ-5d) Scale to evaluate the therapeutic effect. Following treatment, subjective sleep states and the overall scores for pain had improved.Conclusion: The results indicate that Korean medical therapies with Uhwangchungsim-won have beneficial effects on insomnia for patients with herniated intervertebral disks.
Anti-inflammatory drugs with therapeutic effects and drug regulators
Authors: Paul Prateek , . Manvi
Published: November 2021

For prostaglandin production, the enzyme cyclooxygenase (COX) is required. The two COX isoforms are constitutive COX-1 (which is responsible for physiological functions) and inducible COX-2 (involved in inflammation). COX inhibition explains both the medicinal (inhibition of COX-2) and negative effects (inhibition of COX-1) effects of non-steroidal anti-inflammatory medicines (NSAIDs). Nonsteroidal anti-inflammatory medicines (NSAIDs) act by blocking the enzyme cyclooxygenase (COX), which produces prostaglandins (PGs). To a greater or lesser extent, they share similar side effects, such as stomach and renal toxicity. According to a recent study, there are at least two COX isoenzymes. COX-1 is a naturally occurring enzyme that creates prostaglandins (PGs), which protect the stomach and kidneys. Aspirin's well-known anti-cancer impact could also be related to its influence on COX-2, which is expressed in this condition. As a result, selective COX-2 inhibitors may have new therapeutic potential as anticancer drugs, as well as in preventing premature labor and maybe reducing the progression of Alzheimer's disease.
A Novel Drug Delivery of Microspheres
Authors: Walia Smily , Dua J.S. , Prasad D.N.
Published: November 2021

Microspheres are multiparticulate drug delivery systems that distribute medications at a predetermined rate to a specific region. Microspheres are free-flowing powders manufactured from biodegradable proteins or synthetic polymers, with particle sizes ranging from 1 to 1000 micrometers. Benefits of using microspheres in medication delivery, bone tissue manufacture, and pollutant absorption and desorption by regeneration .The study demonstrates how microsphere parameters are planned and measured. Bioadhesive microspheres, polymeric microspheres, magnetic microspheres, floating microspheres, and radioactive microspheres are only a few examples of complicated microspheres. Cosmetics, oral medication administration, target drug delivery, ocular drug delivery, gene delivery, and other industries covered in the paper could all benefit from microspheres. To ensure best therapeutic effectiveness, the agent must be delivered to target tissue at an optimal amount during the appropriate timeframe, with low toxicity and adverse effects. There are several methods for delivering the therapeutic substance to the target site in a controlled manner. The use of microspheres as medication carriers is one such technique. The value of microspheres as a novel drug delivery carrier to accomplish site-specific drug delivery was discussed in this article.

Keywords: Microspheres, method of preparations, polymer bioadhesion, types of microspheres.
Will Mesenchymal Stem Cell Therapy Be Effective In COVID-19?
Authors: Kalai Srinivas , Senthil M , Sambath Kumar R , Kameshwaran R
Published: November 2021

Background: The World Health Organization (WHO) reports that the outbreak of the deadly virus had been noted almost in all the countries worldwide. Newly no standard therapies are available to combat the situation and this remains the major challenge for healthcare professionals to provide effective treatment against the life-threatening condition. A potential regenerative medicine method using the infusion of stem cells for the treatment of lung disorders has been reported. This review attempted to explore the immunomodulatory characteristics of Mesenchymal Stem Cells (MSCs) and how these properties make them beneficial for the treatment of Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) patients.

Objectives: To study the effect of Mesenchymal Stem Cell therapy in treating COVID-19.

Methodology: A literature search was conducted to identify recent research relating to the review's goal of analyzing the relevance of stem cells in battling SARS-CoV-2.

Results: The MSCs settle in the lungs intravenously to enhance the pulmonary microenvironment, minimize immune system over-activation, and encourage regeneration of damaged lung tissues. Its therapeutic properties like immune response inhibition play a major role in combating viruses. The avoidance of cytokine storm is the most important stage in COVID-19 therapy. Their potent immunomodulatory properties have positive effects in avoiding or attenuating the cytokine storm and assisting in the regeneration of injured lung tissues/other organs.

Conclusion: Intravenous human Umbilical Cord-Mesenchymal Stem Cell therapy (hUC-MSC) transplantation is a safe and effective technique that may be used as a restoration and prioritized therapeutic option for treating severe COVID-19.

Keywords: Covid-19, human Umbilical Cord-Mesenchymal Stem Cell therapy (huc-msc), Immune system.
Taking the Notion of Family in Different Cultures Seriously: How Does the Cultural Context Affect Family Business Succession?
Authors: Yau Hoi-yan
Published: November 2021

Taking the Notion of Family in Different Cultures Seriously: How Does the Cultural Context Affect Family Business Succession?
Progression of Pseudolymphoma to true Cutaneous lymphoma, possible role of Platelet-rich plasma (PRP), a case report.
Authors: Balighi Kamran , kasir martin , vahedi maryam , Ghanadan Alireza , Tootoonchi Nasim
Published: November 2021

here we report a case of cutaneous Pseudolymphoma progression to frank
cutaneous lymphoma and resistant to conventional therapy after receiving
Platelet-rich plasma and hair transplantation .these modalities and
their proliferative formulation may be the leading cause or aggravating
factor for such transformation’s specially for patients with positive
family history,
Phytochemicals from bryophytes: Structures and biological activity
Authors: Novakovic Miroslav , Ludwiczuk Agnieszka , Bukvicki Danka , Asakawa Yoshinori
Published: November 2021

Little attention has been paid to the bryophytes as sources for human diet despite the presence of 23,000 species in the world. Some mosses contain Vitamin B1, tocopherols, prostaglandin-like highly unsaturated fatty acids and phenolic compounds. On the other hand, liverworts contain enantiomeric mono-, sesqui- and diterpenoids similar to those found in vascular plants. Additionally, they possess bibenzyls, bis-bibenzyls and polyketides, many of them showing various bioactivity, such as antimicrobial, antiviral, anti-inflammatory, cytotoxicity against cancer cell lines, muscle relaxing, antioxidant and others. In this paper, the structures of phytochemicals from bryophytes and their biological activities are discussed.