bluuebunny/crossref_metadata_2025 huggingface dataset:
Self-Assessment of the Body and Social Competences in the Group of Mothers and Their Adult Daughters
Authors: Izydorczyk Bernadetta , Sitnik-Warchulska Katarzyna , Ostrowska Kinga , Starosta Jolanta
Published: August 2019

The main research objective of this study was seeking the predictive role of general self-esteem and the body image in social competences among women and their biological daughters. As it stands, there is a lack of research showing the mothers and their adult daughters at the same time in the context of measuring the same psychological variables, i.e., general self-esteem, self-assessment of the body and specific social competences in the scope of behaviour in intimate situations, situations requiring social exposure and assertiveness. The study group comprised 102 individuals; 51 pairs of mothers (40–64 years old, M = 51.33) and their biological daughters (19–25 years old, M = 22.49). The following instruments were used: The Rosenberg Self-esteem Scale, the Contour Drawing Rating Scale, the Body Esteem Scale, the Social Competence Scale, categorized interview (to measure BMI and collect data describing the criteria for selection to the research group). The significance of the differences and the stepwise regression analysis were performed. The results of the study demonstrated the following to be significant predictors of social competences in subjects: General self-esteem B = 0.615, discrepancy real-obligatory body image B = 0.275 among daughters, and physical condition B = 0.362 in mothers. The general self-esteem of daughters positively influences all verified types of their social competences (competences in intimate situations, in case of social exposure and ability to be assertive). However, it is the significant predictor only for mothers’ competences in dealing with situations of social exposure. Discrepancy real-obligatory body image: Seems to be the predictor of daughters’ social competences conditioning effectiveness in situations requiring assertiveness. The physical condition among mothers seems to be especially important for their assertiveness and effectiveness in intimate situations. The conflict between the real and the ideal body image is also an important aspect in predicting the assertiveness in the group of mothers. The study results can prove to be helpful in creating preventive and educational programs focused on self-esteem and social competencies in women, including the context of the relation between mothers and their daughters.
Association of lncRNA CCAT2 and CASC8 Gene Polymorphisms with Hepatocellular Carcinoma
Authors: Wu Edie-Rosmin , Hsieh Ming-Ju , Chiang Whei-Ling , Hsueh Kuan-Chun , Yang Shun-Fa , Su Shih-Chi
Published: August 2019

The worldwide incidence of hepatocellular carcinoma (HCC), the major histological type of primary liver cancer, is heterogeneous due to the variable prevalence of etiological factors, indicating a correlation of HCC risk with genetic variations among individuals. Among long non-coding RNAs (lncRNAs) located in the chromosome 8q24 loci and involved in the carcinogenesis are colon cancer associated transcript 2 (CCAT2) and cancer susceptibility candidate 8 (CASC8). In this study, the association of CCAT2 and CASC8 gene polymorphisms with the occurrence of HCC was explored between 397 HCC patients and 1195 controls. We found that carriers of rs6983267 GG in CCAT2 were more susceptible to HCC, with the odds ratio (OR) and adjusted odds ratio (AOR) being 1.532 (95% CI, 1.103–2.129; p = 0.011) and 1.627 (95% CI, 1.120–2.265; p = 0.033), respectively. Moreover, for patients stratified by age (under 65), gender (male only), or status of drinking (habitual drinkers), a protective effect of CASC8 rs3843549 on presenting high Child–Pugh scores, metastatic vascular invasion, or large-size tumors was observed in a dominant model. Collectively, our data reveal association of CCAT2 and CASC8 gene polymorphisms with the occurrence and progression of HCC.
Bone Health and Its Relationship with Impact Loading and the Continuity of Physical Activity throughout School Periods
Authors: Hervás Gotzone , Ruiz-Litago Fatima , Irazusta Jon , Irazusta Amaia , Sanz Begoña , Gil-Goikouria Javier , Fraile-Bermudez Ana Belen , Pérez-Rodrigo Carmen , Zarrazquin Idoia
Published: August 2019

Bone is influenced by physical activity (PA) throughout life, but childhood and adolescence provide a key opportunity to maximize peak bone mass. Thus, it is important to identify the relationship between PA practiced in childhood and young adulthood to design a promotion plan for bone health. The purpose of this study was to analyze the relationship between different impact-loading PAs (and their continuity throughout school periods from childhood to young adulthood) and bone stiffness index (SI). In this cross-sectional study, which was conducted on 145 university students aged 18–21 years, bone measurements were measured by quantitative ultrasonometry (QUS), and PA information was recalled using a self-administered questionnaire. Associations between the SI and the impact of PA performed during secondary school (p = 0.027), high school (p = 0.002), and university (p = 0.016) periods were observed. The continuity of PA over a longer period of time was related to a higher SI (p = 0.007). Those who practiced PA throughout all school periods had a higher SI than those who practiced during primary school only (p = 0.038) or through primary and secondary schools (p = 0.009). These results suggest that impact-loading PA practiced during different school periods is related to higher values of the SI. Therefore, continuous PA from an early age may be an important contributing factor to achieving and maintaining adequate bone health.
Relative Age Effect in the Sport Environment. Role of Physical Fitness and Cognitive Function in Youth Soccer Players
Authors: Huertas Florentino , Ballester Rafael , Gines Honorato José , Hamidi Abdel Karim , Moratal Consuelo , Lupiáñez Juan
Published: August 2019

The need to achieve short-term competitive outcomes in sports may influence the emergence of talent selection strategies, which could bias individuals’ opportunities. The present study aimed to further explore the relative age effect (RAE), a phenomenon that strongly influences youth sport development. The RAE refers to a disproportionately high percentage in sport teams of athletes born early in the selection year. Our primary focus was to explore whether the RAE is supported by behavioral evidence in favor of better fitness—and especially cognitive-attentional functioning—of early as compared to late-born players. A cross-sectional study was conducted on 105 young athletes (u10, n = 52; 9.8 ± 0.3 years old, and u12, n = 53; 11.8 ± 0.2 years old) attending two youth elite soccer academies. Attentional functioning, anthropometrics, physical fitness, and game intelligence were compared across two Age Groups (u10 vs. u12) and four Birth Quarters (BQ1–BQ4). The RAE was statistically significant (p < 0.001), showing that about 50% of participants were born in the first quarter and 75% were born in the first half of the year. More importantly, U12 players outperformed u10 players in measures that were related to sustained attention (with faster and less variable responses; p < 0.001 and p < 0.05, respectively), and in all anthropometric measures (p < 0.001), physical-fitness capacities (p < 0.05). Crucially, neither the attentional measures, game intelligence, anthropometrics, nor physical fitness were affected by BQ (all ps > 0.1 and BF10 between 0.08 and 0.6, showing strong evidence for the null hypothesis). The present findings suggest that the early selection process that occurs during scouting in youth soccer academies offsets the age-related differences that could be anticipated in cognitive skills, anthropometrics, and physical abilities, due to growth and maturation. These birth asymmetries could lead teams to disregard later maturation athletes and athletes born later in the year inducing a larger dropout of those players with the consequent reduction in the talent pool.
Body Fat Mass and Risk of Cerebrovascular Lesions: The PRESENT (Prevention of Stroke and Dementia) Project
Authors: Koh Im-Seok , Minn Yang-Ki , Suk Seung-Han
Published: August 2019

Obesity is known to increase the risk of stroke. It is unclear whether high absolute fat mass (FM) increases the risk of stroke independently. We studied the correlation between FM and silent brain infarction/white matter change (SI/WMC) using brain computed tomography. We selected subjects from the local government health promotion project. We randomly selected a target population that had never been diagnosed with stroke or dementia. FM was measured by bioelectrical impedance analysis (BIA). We divided the subjects into three groups according to the FM (gender-specific tertiles [GTx]). Seven hundred and twenty-two subjects (321 men) between 50 and 75 years of age were recruited. The overall odds ratio (OR) of SI/WMC was 2.23 (95% confidence interval (CI), 1.34–3.71; p = 0.002) times higher in the 37th to 100th percentiles (GT3) than in the first to 32nd percentiles (GT1). When men and women were separated, the OR of GT3 was 1.35 (CI, 0.62–2.94; p = 0.45) in men and 3.2 (CI, 1.60–6.40; p = 0.001) in women. The findings were not found to be statistically significant after adjusting for the well-known stroke risk factors. When the subjects were divided into a high FM (HFMG, GT3) and low FM group (LFMG, GT1 + GT2), the HFMG showed an increased OR of SI/WMC in women. Similar results were seen after adjusted (overall: OR, 1.38; CI, 0.85–2.25, p = 0.198; men: OR, 0.93; CI, 0.422–2.051; p = 0.86; women: OR, 2.02; CI, 1.06–3.86; p = 0.03). The findings suggest that high FM may be an independent risk factor for ischemic stroke among adults free from stroke and dementia, especially in women.
Prospective Application of Activity-Based Proteomic Profiling in Vision Research-Potential Unique Insights into Ocular Protease Biology and Pathology
Authors: Peng Hui , Hulleman John D.
Published: August 2019

Activity-based proteomic profiling (ABPP) is a powerful tool to specifically target and measure the activity of a family of enzymes with the same function and reactivity, which provides a significant advantage over conventional proteomic strategies that simply provide abundance information. A number of inherited and age-related eye diseases are caused by polymorphisms/mutations or abnormal expression of proteases including serine proteases, cysteine proteases, and matrix metalloproteinases, amongst others. However, neither conventional genomic, transcriptomic, nor traditional proteomic profiling directly interrogate protease activities. Thus, leveraging ABPP to probe the activity of these enzyme classes as they relate to normal function and pathophysiology of the eye represents a unique potential opportunity for disease interrogation and possibly intervention.
Regulation of Wound Healing by the NRF2 Transcription Factor—More Than Cytoprotection
Authors: Hiebert Paul , Werner Sabine
Published: August 2019

The nuclear factor-erythroid 2-related factor 2 (NRF2) transcription factor plays a central role in mediating the cellular stress response. Due to their antioxidant properties, compounds activating NRF2 have received much attention as potential medications for disease prevention, or even for therapy. Accumulating evidence suggests that activation of the NRF2 pathway also has a major impact on wound healing and may be beneficial in the treatment of chronic wounds, which remain a considerable health and economic burden. While NRF2 activation indeed shows promise, important considerations need to be made in light of corresponding evidence that also points towards pro-tumorigenic effects of NRF2. In this review, we discuss the evidence to date, highlighting recent advances using gain- and loss-of-function animal models and how these data fit with observations in humans.
Regulation of Brain Cholesterol: What Role Do Liver X Receptors Play in Neurodegenerative Diseases?
Authors: Mouzat Kevin , Chudinova Aleksandra , Polge Anne , Kantar Jovana , Camu William , Raoul Cédric , Lumbroso Serge
Published: August 2019

Liver X Receptors (LXR) alpha and beta are two members of nuclear receptor superfamily documented as endogenous cholesterol sensors. Following conversion of cholesterol in oxysterol, both LXR isoforms detect intracellular concentrations and act as transcription factors to promote expression of target genes. Among their numerous physiological roles, they act as central cholesterol-lowering factors. In the central nervous system (CNS), cholesterol has been shown to be an essential determinant of brain function, particularly as a major constituent of myelin and membranes. In the brain, LXRs act as cholesterol central regulators, and, beyond this metabolic function, LXRs have additional roles such as providing neuroprotective effects and lowering neuroinflammation. In many neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), and multiple sclerosis (MS), dysregulations of cholesterol and oxysterol have been reported. In this paper, we propose to focus on recent advances in the knowledge of the LXRs roles on brain cholesterol and oxysterol homeostasis, neuroinflammation, neuroprotection, and their putative involvement in neurodegenerative disorders. We will discuss their potential use as candidates for both molecular diagnosis and as promising pharmacological targets in the treatment of ALS, AD, or MS patients.
Chlorin, Phthalocyanine, and Porphyrin Types Derivatives in Phototreatment of Cutaneous Manifestations: A Review
Authors: De Annunzio Sarah Raquel , Costa Natalia Caroline Silva , Mezzina Rafaela Dalbello , Graminha Márcia A. S. , Fontana Carla Raquel
Published: August 2019

Recent scientific research has shown the use of chlorin, phthalocyanines, and porphyrins derivatives as photosensitizers in photodynamic therapy in the treatment of various pathologies, including some of the major skin diseases. Thus, the main goal of this critical review is to catalog the papers that used these photosensitizers in the treatment of acne vulgaris, psoriasis, papillomavirus infections, cutaneous leishmaniasis, and skin rejuvenation, and to explore the photodynamic therapy mechanisms against these conditions alongside their clinical benefits.
Modeling Neurological Disorders with Human Pluripotent Stem Cell-Derived Astrocytes
Authors: Suga Mika , Kondo Takayuki , Inoue Haruhisa
Published: August 2019

Astrocytes play vital roles in neurological disorders. The use of human induced pluripotent stem cell (iPSC)-derived astrocytes provides a chance to explore the contributions of astrocytes in human diseases. Here we review human iPSC-based models for neurological disorders associated with human astrocytes and discuss the points of each model.
Structural and Functional Properties of the Capsid Protein of Dengue and Related Flavivirus
Authors: Faustino André F. , Martins Ana S. , Karguth Nina , Artilheiro Vanessa , Enguita Francisco J. , Ricardo Joana C. , Santos Nuno C. , Martins Ivo C.
Published: August 2019

Dengue, West Nile and Zika, closely related viruses of the Flaviviridae family, are an increasing global threat, due to the expansion of their mosquito vectors. They present a very similar viral particle with an outer lipid bilayer containing two viral proteins and, within it, the nucleocapsid core. This core is composed by the viral RNA complexed with multiple copies of the capsid protein, a crucial structural protein that mediates not only viral assembly, but also encapsidation, by interacting with host lipid systems. The capsid is a homodimeric protein that contains a disordered N-terminal region, an intermediate flexible fold section and a very stable conserved fold region. Since a better understanding of its structure can give light into its biological activity, here, first, we compared and analyzed relevant mosquito-borne Flavivirus capsid protein sequences and their predicted structures. Then, we studied the alternative conformations enabled by the N-terminal region. Finally, using dengue virus capsid protein as main model, we correlated the protein size, thermal stability and function with its structure/dynamics features. The findings suggest that the capsid protein interaction with host lipid systems leads to minor allosteric changes that may modulate the specific binding of the protein to the viral RNA. Such mechanism can be targeted in future drug development strategies, namely by using improved versions of pep14-23, a dengue virus capsid protein peptide inhibitor, previously developed by us. Such knowledge can yield promising advances against Zika, dengue and closely related Flavivirus.
Untargeted Metabolomics Reveals Molecular Effects of Ketogenic Diet on Healthy and Tumor Xenograft Mouse Models
Authors: Licha David , Vidali Silvia , Aminzadeh-Gohari Sepideh , Alka Oliver , Breitkreuz Leander , Kohlbacher Oliver , Reischl Roland J. , Feichtinger René G. , Kofler Barbara , Huber Christian G.
Published: August 2019

The application of ketogenic diet (KD) (high fat/low carbohydrate/adequate protein) as an auxiliary cancer therapy is a field of growing attention. KD provides sufficient energy supply for healthy cells, while possibly impairing energy production in highly glycolytic tumor cells. Moreover, KD regulates insulin and tumor related growth factors (like insulin growth factor-1, IGF-1). In order to provide molecular evidence for the proposed additional inhibition of tumor growth when combining chemotherapy with KD, we applied untargeted quantitative metabolome analysis on a spontaneous breast cancer xenograft mouse model, using MDA-MB-468 cells. Healthy mice and mice bearing breast cancer xenografts and receiving cyclophosphamide chemotherapy were compared after treatment with control diet and KD. Metabolomic profiling was performed on plasma samples, applying high-performance liquid chromatography coupled to tandem mass spectrometry. Statistical analysis revealed metabolic fingerprints comprising numerous significantly regulated features in the group of mice bearing breast cancer. This fingerprint disappeared after treatment with KD, resulting in recovery to the metabolic status observed in healthy mice receiving control diet. Moreover, amino acid metabolism as well as fatty acid transport were found to be affected by both the tumor and the applied KD. Our results provide clear evidence of a significant molecular effect of adjuvant KD in the context of tumor growth inhibition and suggest additional mechanisms of tumor suppression beyond the proposed constrain in energy supply of tumor cells.
Cardiovascular Pleiotropic Effects of Natriuretic Peptides
Authors: Forte Maurizio , Madonna Michele , Schiavon Sonia , Valenti Valentina , Versaci Francesco , Biondi Zoccai Giuseppe , Frati Giacomo , Sciarretta Sebastiano
Published: August 2019

Atrial natriuretic peptide (ANP) is a cardiac hormone belonging to the family of natriuretic peptides (NPs). ANP exerts diuretic, natriuretic, and vasodilatory effects that contribute to maintain water–salt balance and regulate blood pressure. Besides these systemic properties, ANP displays important pleiotropic effects in the heart and in the vascular system that are independent of blood pressure regulation. These functions occur through autocrine and paracrine mechanisms. Previous works examining the cardiac phenotype of loss-of-function mouse models of ANP signaling showed that both mice with gene deletion of ANP or its receptor natriuretic peptide receptor A (NPR-A) developed cardiac hypertrophy and dysfunction in response to pressure overload and chronic ischemic remodeling. Conversely, ANP administration has been shown to improve cardiac function in response to remodeling and reduces ischemia-reperfusion (I/R) injury. ANP also acts as a pro-angiogenetic, anti-inflammatory, and anti-atherosclerotic factor in the vascular system. Pleiotropic effects regarding brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) were also reported. In this review, we discuss the current evidence underlying the pleiotropic effects of NPs, underlying their importance in cardiovascular homeostasis.
A Strategy Based on GC-MS/MS, UPLC-MS/MS and Virtual Molecular Docking for Analysis and Prediction of Bioactive Compounds in Eucalyptus Globulus Leaves
Authors: Pan Meng , Lei Qicheng , Zang Ning , Zhang Hong
Published: August 2019

The discovery of medicinal plants is crucial for drug development. Eucalyptus globulus leaves are used as a traditional medicine in many areas of world due to herbicidal and insecticidal activity. While natural products are difficult to be separated and activity assayed, a new approach is needed to predict the active ingredients therein. In this study, a new method for screening active compounds extracted from E. globulus leaves was developed by GC-MS/MS and UPLC-MS/MS combined with molecular docking technology. Predicted compounds with high activity were proposed. Firstly, 35 volatile compounds and 34 aqueous extracted compounds were extracted from E. globulus leaves, and identified by GC-MS/MS and UPLC-MS/MS. The herbicidal receptor (1BX9) was then docked with the identified compounds by docking software, evaluated by docking models and seven scoring functions. The results showed that gallic acid had a strong inhibitory activity of 1BX9, which was speculated to be the main reason for the inhibitory effect of E. globulus leaves. Finally, allelopathic tests of gallic acid, citric acid, and isopulegol were carried out on grass seeds to verify its inhibitory activity against herbicide receptor 1BX9. The results show that the method can screen compounds with specific activity from a complex system of medicinal plants, which is very important for the screening of new active ingredients, confirmation of new medicinal ingredients, and the in-depth development of animal and plant medicines.
Peroxisomes in Immune Response and Inflammation
Authors: Di Cara Francesca , Andreoletti Pierre , Trompier Doriane , Vejux Anne , Bülow Margret H. , Sellin Julia , Lizard Gérard , Cherkaoui-Malki Mustapha , Savary Stéphane
Published: August 2019

The immune response is essential to protect organisms from infection and an altered self. An organism’s overall metabolic status is now recognized as an important and long-overlooked mediator of immunity and has spurred new explorations of immune-related metabolic abnormalities. Peroxisomes are essential metabolic organelles with a central role in the synthesis and turnover of complex lipids and reactive species. Peroxisomes have recently been identified as pivotal regulators of immune functions and inflammation in the development and during infection, defining a new branch of immunometabolism. This review summarizes the current evidence that has helped to identify peroxisomes as central regulators of immunity and highlights the peroxisomal proteins and metabolites that have acquired relevance in human pathologies for their link to the development of inflammation, neuropathies, aging and cancer. This review then describes how peroxisomes govern immune signaling strategies such as phagocytosis and cytokine production and their relevance in fighting bacterial and viral infections. The mechanisms by which peroxisomes either control the activation of the immune response or trigger cellular metabolic changes that activate and resolve immune responses are also described.
Collaborative Mapping and Digital Participation: A Tool for Local Empowerment in Developing Countries
Authors: Panek Jiri , Netek Rostislav
Published: August 2019

There has been an enormous technological boom that impacted all areas of geoscience in the past few decades. Part of the change was also the process of democratization of cartography as well as geographic information systems (GIS), together with new approaches that have emerged, bringing social dimension into cartography and GIS. These new approaches were variously labelled as critical cartography, collaborative mapping, digital citizenship, Bottom-up GIS and Participatory GIS. The paper describes the role of collaborative mapping and digital participation in the process of community building and community assets mapping. Secondly, we will use the examples of Kenya and Peru to support our findings of community development. Thirdly, we will discuss a possible further development within the use of OpenStreetMap (OSM) for remote communities. The analysis compares approaches and experiences in different countries on different continents.
The Unique Immunoregulatory Function of Staphylococcus Aureus Lipoteichoic Acid in Dendritic Cells
Authors: Saito Suguru , Lin Su-Hui , Wu Hui-Ya
Published: August 2019

Background and objectives: Lipoteichoic acid (LTA) is a structural component of Staphylococcus aureus (S. aureus) that induces severe infection disease and skin inflammation such as atopic dermatitis (AD); the biological function of LTA is still unclear. Dendritic cells (DC) are important regulators in the immune system, and the cells ectopically recognize agents that have an influence on the host immune response. We aimed to reveal the DC-based immune response against LTA to understand the novel mechanism in S. aureus related acute skin inflammation. Materials and Methods: Different doses of LTA were applied on the epidermal barrier dysfunction mice in order to evaluate the epidermal thickness, DC activation, and subsequent immunological response such as effector T-cell (Teff) activation. In addition, bone marrow-derived dendritic cells (BMDCs) were also treated with LTA, and the immunoregulatory mechanism was investigated. Results: A low dose of LTA did not induce skin inflammation at all; however, a high dose of LTA induced severe skin inflammation on epidermalba rrier dysfunction mice. Those symptoms were correlated with the DC and Teff activation status. The low-dose treatment of LTA showed a suppressive effect in pro-inflammatory cytokine production via a Toll-like receptor 2 (TLR2)-dominant manner, and the effect was significant regarding the co-treatment with another stimulatory signal such as TLR4 by lipopolysaccharide (LPS). Meanwhile, a high-dose treatment of LTA completely abolished the suppressive effect of a low-dose treatment. This phenomenon was based on C-type lectin receptors (CLRs), because the high dose of LTA greatly enhanced the expression of CLRs in the activated DCs. Conclusions: DCs sensed the dose difference of LTA, and the mechanism contributed to regulating immune responses such as effector T-cell activation, which was directly correlated with inflammatory response. This finding might provide an understanding for the novel immunological effect of LTA and S. aureus pathogenesis under inflammation, as well as the mechanism of symbiosis.
Application of Laser Scanning Confocal Microscopy for the Visualization of M. tuberculosis in Lung Tissue Samples with Weak Ziehl–Neelsen Staining
Authors: Erokhina Maria V. , Lepekha Larisa N. , Voronezhskaya Elena E. , Nezlin Leonid P. , Avdienko Vadim G. , Ergeshov Atadzhan E.
Published: August 2019

One of the key requirements for the diagnosis of pulmonary tuberculosis is the identification of M. tuberculosis in tissue. In this paper, we present the advantages of specific fluorescent antibody labelling, combined with laser scanning confocal microscopy (LSCM), for the detection of M. tuberculosis in histological specimens of lung tissues. We demonstrate that the application of LSCM allows: (i) The automatic acquisition of images of the whole slice and, hence, the determination of regions for subsequent analysis; (ii) the acquisition of images of thick (20–40 μm) slices at high resolution; (iii) single bacteria identification; and (iv) 3D reconstruction, in order to obtain additional information about the distribution, size, and morphology of solitary M. tuberculosis; as well as their aggregates and colonies, in various regions of tuberculosis inflammation. LSCM allows for the discrimination of the non-specific fluorescence of bacteria-like particles and their aggregates presented in histological lung samples, from the specific fluorescence of labelled M. tuberculosis, using spectrum emission analysis. The applied method was effective in the identification of M. tuberculosis in lung histological samples with weak Ziehl–Neelsen staining. Altogether, combining immunofluorescent labelling with the application of LSCM visualization significantly increases the effectiveness of M. tuberculosis detection.
Motor and Postural Patterns Concomitant with General Movements Are Associated with Cerebral Palsy at Term and Fidgety Age in Preterm Infants
Authors: Ferrari Fabrizio , Plessi Carlotta , Lucaccioni Laura , Bertoncelli Natascia , Bedetti Luca , Ori Luca , Berardi Alberto , Della Casa Elisa , Iughetti Lorenzo , D’Amico Roberto
Published: August 2019

General movements (GMs) in combination with neurological examination and magnetic resonance imaging at term age can accurately determine the risk of cerebral palsy. The present study aimed to assess whether 11 motor and postural patterns concomitant with GMs were associated with cerebral palsy. Video recordings performed after birth in 79 preterm infants were reviewed retrospectively. Thirty-seven infants developed cerebral palsy at 2 years corrected age and the remaining 42 showed typical development. GMs were assessed from preterm to fidgety age and GM trajectories were defined. The 11 motor and postural patterns were evaluated at each age and longitudinally, alone and in combination with GM trajectories. A logistic regression model was used to assess the association between GMs, concomitant motor and postural patterns, and cerebral palsy. We confirmed that high-risk GM trajectories were associated with cerebral palsy (odds ratio = 44.40, 95% confidence interval = 11.74–167.85). An association between concomitant motor and postural patterns and cerebral palsy was found for some of the patterns at term age and for all of them at fidgety age. Therefore, at term age, concomitant motor and postural patterns can support GMs for the early diagnosis of cerebral palsy.
Patients with Inflammatory Bowel Disease Are at an Increased Risk of Parkinson’s Disease: A South Korean Nationwide Population-Based Study
Authors: Park Seona , Kim Jihye , Chun Jaeyoung , Han Kyungdo , Soh Hosim , Kang Eun Ae , Lee Hyun Jung , Im Jong Pil , Kim Joo Sung
Published: August 2019

Background and Aims: It is not known whether inflammatory bowel disease (IBD) enhances the risk of Parkinson’s disease (PD) or whether PD diagnosis is the result of increased health care use. We determined the risk of developing PD among patients with IBD in terms of health care and medication use. Methods: A nationwide population-based study was conducted using claims data from the Korean National Health care Insurance service. From 2010 to 2013, patients with Crohn’s disease (CD) and ulcerative colitis (UC) were identified through both International Classification of Disease, Tenth Revision (ICD-10) and national rare intractable disease (RID) registration program codes. We compared 38,861 IBD patients with age and sex-matched non-IBD individuals at a ratio of 1:3. Patients with newly diagnosed PD were identified through both ICD-10 and RID codes. Results: The incidence of PD among patients with IBD was 49 per 100,000 person-years. The risk of developing PD in patients with IBD was significantly higher than controls even after adjustment for health care use (adjusted hazard ratio (aHR), 1.87; P < 0.001). Compared to controls, the risk of PD was significantly higher in patients with CD (aHR, 2.23; P = 0.023) and UC (aHR, 1.85; P < 0.001). Corticosteroid use showed a preventive effect on developing PD in patients with CD (aHR 0.08; P < 0.001), but not UC (aHR, 0.75; P = 0.213). Among 2110 patients receiving anti-tumor necrosis factor (anti-TNF), none of the treated patients experienced PD during 9950 person-years. Conclusion: Patients with IBD are at an increased risk of PD, regardless of health care use. Corticosteroid and anti-TNF use may prevent PD in patients with IBD.
Temperature-Dependent Rheological and Viscoelastic Investigation of a Poly(2-methyl-2-oxazoline)-b-poly(2-iso-butyl-2-oxazoline)-b-poly(2-methyl-2-oxazoline)-Based Thermogelling Hydrogel
Authors: Lübtow Michael M. , Mrlik Miroslav , Hahn Lukas , Altmann Alexander , Beudert Matthias , Lühmann Tessa , Luxenhofer Robert
Published: August 2019

The synthesis and characterization of an ABA triblock copolymer based on hydrophilic poly(2-methyl-2-oxazoline) (pMeOx) blocks A and a modestly hydrophobic poly(2-iso-butyl-2-oxazoline) (piBuOx) block B is described. Aqueous polymer solutions were prepared at different concentrations (1–20 wt %) and their thermogelling capability using visual observation was investigated at different temperatures ranging from 5 to 80 °C. As only a 20 wt % solution was found to undergo thermogelation, this concentration was investigated in more detail regarding its temperature-dependent viscoelastic profile utilizing various modes (strain or temperature sweep). The prepared hydrogels from this particular ABA triblock copolymer have interesting rheological and viscoelastic properties, such as reversible thermogelling and shear thinning, and may be used as bioink, which was supported by its very low cytotoxicity and initial printing experiments using the hydrogels. However, the soft character and low yield stress of the gels do not allow real 3D printing at this point.
Evaluation of Fracture Resistance and Microleakage of Endocrowns with Different Intracoronal Depths and Restorative Materials Luted with Various Resin Cements
Authors: Ghajghouj Ouqba , Taşar-Faruk Simge
Published: August 2019

The aim of this study was to determine the effect of restoration design on the fracture resistance of different computer-aided design/computer-aided manufacturing (CAD/CAM) ceramics and investigate the marginal leakage of endocrowns according to different types of cement. In total, 96 extracted mandibular first premolars were used for fabrication of endocrowns; 48 of the endocrowns were divided into 6 groups (n = 8) according to intracoronal cavity depth (2 and 3 mm) and CAD/CAM ceramics (lithium disilicate IPS e.max-CAD, zirconia-reinforced glass-ceramic Vita Suprinity, and poly-ether-ether-ketone (PEEK)). Teeth were subjected to a fracture resistance test with a universal test machine following thermo-cycling. Failure modes were determined by stereomicroscope after the load test. The rest of the endocrowns (n = 48) were produced by Vita Suprinity ceramic and divided into 6 groups (n = 8) according to the cement used (Panavia V5, Relyx Ultimate, and GC cement) with intracoronal cavity depths of 2 and 3 mm. Microleakage tests were performed using methylene blue with stereomicroscope after thermo-cycling. Numerical data for both fracture resistance and microleakage tests were obtained and evaluated by three-way ANOVA. PEEK endocrowns had higher fracture resistance compared to lithium disilicate and Vita Suprinity. Panavia V5 cement had the lowest degree of microleakage, while GC cement had the highest. Different intracoronal cavity depths had no correlation with fracture resistance and microleakage.
On Pata–Suzuki-Type Contractions
Authors: Alqahtani Obaid , Himabindu Venigalla Madhulatha , Karapınar Erdal
Published: August 2019

In this paper, we aim to obtain fixed-point results by merging the interesting fixed-point theorem of Pata and Suzuki in the framework of complete metric space and to extend these results by involving admissible mapping. After introducing two new contractions, we investigate the existence of a (common) fixed point in these new settings. In addition, we shall consider an integral equation as an application of obtained results.
On New Solutions of Time-Fractional Wave Equations Arising in Shallow Water Wave Propagation
Authors: Jena Rajarama Mohan , Chakraverty Snehashish , Baleanu Dumitru
Published: August 2019

The primary objective of this manuscript is to obtain the approximate analytical solution of Camassa–Holm (CH), modified Camassa–Holm (mCH), and Degasperis–Procesi (DP) equations with time-fractional derivatives labeled in the Caputo sense with the help of an iterative approach called fractional reduced differential transform method (FRDTM). The main benefits of using this technique are that linearization is not required for this method and therefore it reduces complex numerical computations significantly compared to the other existing methods such as the perturbation technique, differential transform method (DTM), and Adomian decomposition method (ADM). Small size computations over other techniques are the main advantages of the proposed method. Obtained results are compared with the solutions carried out by other technique which demonstrates that the proposed method is easy to implement and takes small size computation compared to other numerical techniques while dealing with complex physical problems of fractional order arising in science and engineering.
Purification, Characterization and Evaluation of Inhibitory Mechanism of ACE Inhibitory Peptides from Pearl Oyster (Pinctada fucata martensii) Meat Protein Hydrolysate
Authors: Liu Pengru , Lan Xiongdiao , Yaseen Muhammad , Wu Shanguang , Feng Xuezhen , Zhou Liqin , Sun Jianhua , Liao Anping , Liao Dankui , Sun Lixia
Published: August 2019

Angiotensin-I-converting enzyme (ACE) inhibitory peptides derived from natural products have shown a blood pressure lowering effect with no side effects. In this study, two novel ACE inhibitory peptides (His-Leu-His-Thr, HLHT and Gly-Trp-Ala, GWA) were purified from pearl oyster (Pinctada fucata martensii) meat protein hydrolysate with alkaline protease by ultrafiltration, polyethylene glycol methyl ether modified immobilized metal ion affinity medium, and reverse-phase high performance liquid chromatography. Both peptides exhibited high ACE inhibitory activity with IC50 values of 458.06 ± 3.24 μM and 109.25 ± 1.45 μM, respectively. Based on the results of a Lineweaver-Burk plot, HLHT and GWA were found to be non-competitive inhibitor and competitive inhibitor respectively, which were confirmed by molecular docking. Furthermore, the pearl oyster meat protein hydrolysate exhibited an effective antihypertensive effect on SD rats. These results conclude that pearl oyster meat protein is a potential resource of ACE inhibitory peptides and the purified peptides, HLHT and GWA, can be exploited as functional food ingredients against hypertension.
Temporary Fixation of Reduction with Fabric Adhesive Bandage in the Surgical Treatment of Pediatric Supracondylar Humerus Fractures
Authors: Turhal Ozan , Kınaş Mustafa , Karaduman Zekeriya Okan , Turhan Yalçın , Kaya Onur , Güler Cemal
Published: August 2019

Background and objectives: Supracondylar humerus fractures are common in children and can be surgically treated. However, the general surgical procedures involving reduction and fixation might lead to reduction loss, failure to direct the Kirschner (K)-wire toward the desired position, prolonged surgery, or chondral damage. This study aimed to show that temporary fixation of closed reduction with a fabric adhesive bandage in pediatric supracondylar humerus fractures could maintain reduction so that surgical treatment can be easily performed by a single physician. Materials and Methods: Forty-six patients with Gartland type 3 supracondylar humerus fractures who underwent surgical treatment between May 2017 and June 2018 were retrospectively evaluated. Fluoroscopy-guided reduction and fixation were performed from the distal third of the forearm to the proximal third of the humerus using a fabric adhesive bandage. Two crossed pins were applied on the fracture line by first inserting a lateral-entry K-wire and then inserting another K-wire close to the anterior aspect of the medial epicondyle and diverging from the ulnar nerve tunnel. A tourniquet was not applied in any patient and no patients required open reduction. Results: The study included 32 boys (69.6%) and 14 girls (30.4%) (mean age, 7.1; range, 2–16 years). The mean hospital stay and follow-up duration were 4.3 ± 3.9 days and 48.1 ± 14.3 weeks, respectively. Heterotopic ossification was detected in one patient, and ulnar nerve neuropraxia was detected in another patient. Functional (according to Flynn criteria) and cosmetic outcomes were excellent in 95.6%, moderate in 2.2%, and poor in 2.2% of patients. The mean duration of fixation of the closed reduction with a fabric adhesive bandage was 8.1 ± 3.9 min, and the mean duration of pinning was 7.9 ± 1.4 min. Conclusions: Temporary preoperative fixation of supracondylar humerus fractures that require surgical treatment with a fabric adhesive bandage may be significantly convenient in practice.
The Effects of Electrochemical Hydrogen Charging on Room-Temperature Tensile Properties of T92/TP316H Dissimilar Weldments in Quenched-and-Tempered and Thermally-Aged Conditions
Authors: Ševc Peter , Falat Ladislav , Čiripová Lucia , Džupon Miroslav , Vojtko Marek
Published: August 2019

The influence of isothermal aging at 620 °C in combination with subsequent electrochemical hydrogen charging at room-temperature was studied on quenched-and-tempered T92/TP316H martensitic/austenitic weldments in terms of their room-temperature tensile properties and fracture behavior. Hydrogen charging of the weldments did not significantly affect their strength properties; however, it resulted in considerable deterioration of their plastic properties along with significant impact on their fracture characteristics and failure localization. The hydrogen embrittlement plays a dominant role in degradation of the plastic properties of the weldments already in their initial material state, i.e., before thermal aging. After thermal aging and subsequent hydrogen charging, mutual superposition of thermal and hydrogen embrittlement phenomena had led to clearly observable effects on the welds deformation and fracture processes. The measure of hydrogen embrittlement was clearly lowered for thermally aged material state, since the contribution of thermal embrittlement to overall degradation of the weldments has dominated. The majority of failures of the weldments after hydrogen charging occurred in the vicinity of T92 BM/Ni weld metal (WM) fusion zone; mostly along the Type-II boundary in Ni-based weld metal. Thus, regardless of aging exposure, the most critical failure regions of the investigated weldments after hydrogen charging and tensile straining at room temperature are the T92 BM/Ni WM fusion boundary and Type-II boundary acting like preferential microstructural sites for hydrogen embrittling effects accumulation.
Roles of MgO and Al2O3 on the Viscous and Structural Behavior of Blast Furnace Primary Slag, Part 1: C/S = 1.3 Containing TiO2
Authors: Li Tingle , Sun Changyu , Song Sunny , Wang Qi
Published: August 2019

This research provides fundamental insight into the roles of MgO and Al2O3 on the viscous and structural behaviors of CaO−SiO2−MgO−Al2O3−10 mass% TiO2−5 mass% FeO (CaO/SiO2 = 1.3) system primary blast furnace slag. The slag viscosity is measured by the rotating cylinder method, which is essential to the efficient and stable operation of a blast furnace. The network structure characterization of the quenched vitreous samples was conducted using Fourier Transformation Infrared (FTIR) and Raman spectroscopy. Usual viscous behaviors (that the slag viscosity and the activation energy decrease or increase with increasing MgO or Al2O3 content) were observed, corresponding to changes in the network structure certified by FTIR and Raman analyses. It seems that the addition of MgO and Al2O3 prefers to modify the Si−O and Ti−O network in the present slag. When the slag composition reaches 10% MgO and 12% Al2O3, unexpected viscous behaviors (that MgO increases viscosity and Al2O3 decreases viscosity) are discovered. The roles of MgO and Al2O3 could be interpreted by changes in the arrangement structure of ions in liquid, corresponding to changes in the primary equilibrium phase region determined in phase diagrams and variation in the difference between the experimental and liquidus temperature, respectively.
Phase Coherence Imaging for Near-Surface Defects in Rails Using Cross-Correlation of Ultrasonic Diffuse Fields
Authors: Zhang Haiyan , Shao Mintao , Fan Guopeng , Zhang Hui , Zhu Wenfa , Zhu Qi
Published: August 2019

In this paper, phase coherence imaging is proposed to improve spatial resolution and signal-to-noise ratio (SNR) of near-surface defects in rails using cross-correlation of ultrasonic diffuse fields. The direct signals acquired by the phased array are often obscured by nonlinear effects. Thus, the output image processed by conventional post-processing algorithms, like total focus method (TFM), has a blind zone close to the array. To overcome this problem, the diffuse fields, which contain spatial phase correlations, are applied to recover Green’s function. In addition, with the purpose of improving image quality, the Green’s function is further weighted by a special coherent factor, sign coherence factor (SCF), for grating and side lobes suppression. Experiments are conducted on two rails and data acquisition is completed by a commercial 32-element phased array. The quantitative performance comparison of TFM and SCF images is implemented in terms of the array performance indicator (API) and SNR. The results show that the API of SCF is significantly lower than that of TFM. As for SNR, SCF achieved a better SNR than that of TFM. The study in this paper provides an experimental reference for detecting near-surface defects in the rails.
Analysis of the Fatigue Crack Evolution of Corrugated Web Girders
Authors: Wei Guoqian , Ye Fan , Li Shanshan , Chen Siwen
Published: August 2019

Based on linear elastic fracture mechanics (LEFM), the fatigue crack evolution process and behavior of corrugated web girders were studied. The global finite element analysis (FEA) model of corrugated web girders was first developed and the equivalent structural stress method was used to reveal the dangerous locations along the weld under the bending load. The weld toe between the tension flange and the web weld, which is near the intersection of the inclined fold and the parallel fold, was determined as the fatigue crack easy-initiating location. Then a small region containing the crack-prone site was extracted as the sub-model for a crack propagating simulation. A semi-circle initial crack with 0.1 mm radius was inserted at the crack easy-initiating location. The stress intensity factors (SIFs; KI, KII, and KIII) of some discrete points along the crack front were calculated by the M-integral method. Based on Nasgro law, the geometry of the new crack front with a given extension length was obtained. Finally, the complete evolution process of the crack propagation was simulated. Results showed that the dominant crack propagating mode is open type (Mode I) and KI is the most important propagating driving force. According to the crack front shape evolution, the whole propagating process was divided into 6 stages. An obvious kink of the crack was found in stage 1, which covered only a very short time. The stages 3, 4 and 5 accounted for the majority of life, among which the stage 3 accounted for as high as 81% of the total life. Therefore, the cycles of the weld toe crack propagating from 0.1 mm to the thickness of the flange can be defined as the prediction life of this kind of structures.