bluuebunny/crossref_metadata_2025 huggingface dataset:
VERDE URBANO Y RESILIENCIA: UNA EXPLORACIÓN EN CÓRDOBA, FORTÍN Y AMATLÁN, VERACRUZ, MÉXICO
Authors: Muñoz-Márquez T Rafael A. , Hidalgo-Contreras Juan V.
Published: November 2022

El presente artículo muestra la cantidad y ubicación de Verde Urbano (VU) en Amatlán, Córdoba y Fortín, Veracruz, México, en el contexto de la resiliencia urbana hacia el calentamiento global. Los objetivos de este trabajo son: 1) conocer la situación de este recurso en términos de su disponibilidad (dotación) por área presente; 2) medir las distancias que separan al verde de la población; y 3) determinar la población servida a través del Verde Urbano Público (VUP) y Verde Urbano en general (VU-NDVI), así como contrastar con las recomendaciones de dotación y distancia de la Secretaría de Desarrollo Agrario, Territorial y Urbano (SEDATU). Las hipótesis de trabajo son: a) Fortín, Córdoba y Amatlán presentan una dotación de VUP por debajo de la recomendada por la OMS, pero tiene posibilidad de dotaciones superiores, considerando el VU-NDVI; y b) Fortín, Córdoba y Amatlán poseen un sistema de VUP a una distancia máxima de 400 metros de cada manzana, y contiene áreas VU-NDVI a menores distancias. Con datos censales, cartográficos, procesamiento de imágenes de satélite, utilización de Sistemas de Información Geográficos, verificación en campo de los datos, y análisis estadísticos, se determinó la cantidad de VUP y VU-NDVI, las dotaciones de área verde por habitante, y las distancias que separan los dos tipos de verde de la población. Los resultados mostraron, por una parte, que la dotación de VUP por habitante está por debajo de las recomendaciones de la OMS, pero no el VU-NDVI y, por otra, que el VUP supera la distancia máxima recomendada por la SEDATU, pero no así el VU-NDVI. Finalmente, se señala que, aunque la mayoría de la población se encuentra servida con VUP de acuerdo con la SEDATU (aunque con superficies muy variadas), el VU-NDVI sirve al 100% de ella. Los resultados muestran el potencial de este último para aumentar la cuota de verde en ciudades como las analizadas.
El origen de los humedales peruanos y su relación con los procesos geológico-ambientales de Sudamérica: Una revisión
Authors:   , Cerna Arrué Ariana Paola
Published: November 2022

El Perú cuenta con diversos humedales altamente productivos, distribuidos en sus tres regiones geográficas (costa, sierra y selva). Estos ecosistemas han estado sometidos a diversos eventos hidrometereológicos, climáticos y antrópicos. El análisis de su origen puede servir para identificar cambios en el entorno geomórfico e hidrológico, así como procesos evolutivos biológicos. El presente trabajo tuvo como objetivo sintetizar la información existente sobre los procesos geológico-ambientales que definen el origen de los humedales actuales peruanos, así como los factores y eventos implicados en el desarrollo del paisaje actual de esta región de América Latina. Para ello, se realizó una compilación sistemática de la literatura relacionada a la historia de estos ecosistema usando las plataformas Science Direct, Scopus y Scielo; el análisis fue dividido en humedales costeros, andinos y amazónicos. Se encontraron 144 artículos sobre la historia de los humedales; de estos, 72 (50%) corresponden a estudios en la región andina, 59 (41.67%) a la región amazónica y 12 (8.33%) a la región costera. El número de artículos publicados por año tuvo una tendencia creciente y los humedales más estudiados fueron los de la Cuenca del Amazonas, el Lago Titicaca y los lagos de la Cordillera Blanca. El origen de los humedales del Perú se relaciona a procesos tectónicos, de desglaciación, afloramiento de aguas subterráneas, precipitaciones e intrusiones marinas, pero también a procesos como el ENSO, tsunamis y a actividades antrópicas como la agricultura, ganadería y procesos de urbanización. Este estudió permitió identificar los vacíos de información en cuanto al área de estudio, permitiendo promover la investigación en la temática abordada.
Plan de negocio para la elaboración y comercialización de comida BARF para perros en Lima Moderna
Authors:   , Campusano Cebrecos Rita Esperanza , Carhuatocto Bustamante Melissa Jezabel , Inoñan Quiñones Julio Rolando , Marroquin Romero Katherine Deyanire , Neciosup Quesñay Darwin
Published: November 2022

La presente investigación tiene la finalidad de la creación de una empresa dedicada a la elaboración y comercialización de comida Barf para perros, elaborados a base de pollo, pavo, carne de res y otros ingredientes como frutas y verduras que pueden ser consumidos por nuestras mascotas. Nuestra empresa "Barf Burguer” producirá y comercializará nuestro producto en tres distintos sabores, en presentaciones de 1 kg que contarán con su debido valor nutricional e información relevante para el consumo de los perros de mascota como la ración que a cada uno corresponde, según su peso, edad y otras variables de salud que considerar de acuerdo a las indicaciones del veterinario de cabecera. Hemos considerado como mercado objetivo a tres distritos de Lima: Miraflores, Surco y Barranco, que podrán conocer y solicitar nuestro producto a través de las plataformas digitales, para posteriormente recibirlo a través de nuestro Delivery personalizado que se encarga de velar por la calidad e integridad de nuestro producto. Cabe precisar, que cada uno de los aspectos de diversos rubros que podrán visualizar en este proyecto han sido previamente investigados y analizados por los integrantes del equipo de investigación que se considera pet lover.
Síndrome metabólico asociado a mayor daño en pacientes con Lupus Erimatoso Sistémico del Hospital Guillermo Almenara Irigoyen entre enero 2012 enero 2020
Authors:   , Saldaña Alvarado Fiorella Vanessa , Diaz Ramirez Fernando Piero
Published: November 2022

Objetivos: Determinar la asociación entre síndrome metabólico (SM) y mayor daño orgánico en pacientes con lupus (LES). Materiales y métodos: evaluamos a 314 pacientes, miembros de la Cohorte de Lupus del Almenara, durante enero 2012 a enero 2020. Aplicamos los criterios de: International Diabetes Fedetation/American Health Association/National Heart, Lung and Blood Institute para determinar SM; el índice de daño de Systemic Lupus International Collaborating Clinics/American College of Rheumatology para determinar daño; y Systemic Lupus Erythematosus Disease Activity Index para evaluar la actividad. Realizamos un análisis univariado y multivariado usando ecuaciones de estimación generalizada, ajustado para potenciales confusores (factores demográficos, factores relacionados a la enfermedad y tratamiento). El análisis estadístico se realizó en el programa SPSS v.28.0. Resultados: Se incluyeron 314 pacientes y 1695 visitas, el 26.2% de pacientes tuvo SM. Entre los componentes de SM, destacaron la obesidad central (76.1%), seguido de hipertensión (40.5%), HDL disminuidos (39.2%), triglicéridos elevados (31.4%) y diabetes (11.1%). En el análisis multivariado, no hubo asociación de SM con mayor daño en LES (OR: 1.143; 0.818-1.597, P=0.432). la hipertensión se asoció a mayor daño (OR: 1.645; 1.187-2.280, P=0.003). Obesidad central se asoció con menos daño (OR: 0.637; 0.441-0.920, P=0.016). Los otros componentes no se asociaron con daño: HDL disminuidos (OR: 0.812; 0.595-1.109, P=0.191), triglicéridos elevados (OR: 1.087; 0.781-1.511, P=0.621) y diabetes (OR: 0.984; 0.649-1.492, P=0.939). Conclusión: el SM no se asoció a mayor daño en LES. La hipertensión se asocia al incremento el daño. Debida a la alta prevalencia del SM, debería incluirse en la evaluación rutinaria de pacientes lúpicos.
Nivel de conocimiento y actitudes hacia lactancia materna exclusiva en los alumnos del internado del año 2020 de la carrera de Medicina Humana y Nutrición y Dietética de la Universidad Científica del Sur
Authors:   , Caceres Chuquizuta Gianfranco Enrique , Estrada Villa Claudia
Published: November 2022

Objetivos: Determinar el nivel de conocimientos y actitudes hacia lactancia materna exclusiva en los alumnos del internado del año 2020 de las carreras de Medicina humana y Nutrición de la Universidad Científica del Sur y hallar la asociación entre variables intervinientes. Metodología: Estudio observacional, analítico y corte transversal. Población conformada por internos de dos carreras de salud en una universidad de Lima, Perú. Se usaron dos cuestionarios adaptados, validados por un comité de expertos, para evaluar el nivel de conocimientos y actitudes. Categorizados en tres grupos propuestos por antecedentes. Se compararon proporciones entre variables con la prueba de Fischer y con regresiones logísticas se evaluó la asociación entre carrera y las variables desenlace. Resultados: El 79.11% de internos posee un nivel de conocimiento alto; el 20.59%, nivel medio, y ninguno posee nivel bajo según los puntos de corte establecidos. Sobre actitudes, el 17.65% muestra actitudes de acuerdo a favorecer esta práctica, mientras el 72.06% no se encuentra en acuerdo, ni desacuerdo y el 10.29% posee actitudes en desacuerdo. Con regresiones logísticas se encontró asociación entre la carrera de Nutrición y poseer un nivel Medio de conocimientos. Conclusiones: La mayoría de internos muestra un nivel de conocimientos alto y actitudes ni acuerdo ni desacuerdo, por lo que se recomienda intervenciones en la formación profesional y así consolidar una orientación completa. La presencia de hijos y/o hermanos al menos 10 años menores se asocia a un nivel de conocimiento alto.
Evaluación de la eficiencia del tratamiento de aguas residuales provenientes de un matadero avícola con la tecnología de los vermifiltros
Authors:   , Moscoso Palomares Wilfredo Enrique
Published: November 2022

En los últimos años, los vermifiltros presentan una alternativa muy atractiva para el tratamiento de aguas residuales debido a su bajo costo y elevados porcentajes de remoción. Por ello, la presente investigación tuvo como fin evaluar la eficiencia del vermifiltro (VF) con respecto al filtro control en la reducción de los parámetros físico-químicos de las aguas residuales provenientes de un matadero avícola. La metodología incluyó un vermifiltro con cuatro capas (grava grande con arena, grava pequeña, arena y tierra con lombrices Eisenia fetida) y un filtro control sin lombrices de tierra, en los que se buscó demostrar la eficiencia del vermifiltro a largo plazo, a través de la reducción de los parámetros físico-químicos (demanda química de oxígeno o DQO, aceites y grasas o AyG, sólidos suspendidos totales o SST, demanda bioquímica de oxígeno o DBO y pH) de los efluentes. El diseño experimental constó de tres repeticiones, utilizándose la prueba de Kruskal-Wallis debido que no se cumplió con la normalidad y homogeneidad de varianzas. La eficiencia en el VF aumentó a través de los ensayos, llegando a tener una remoción del 96.15% ± 0.48% de DQO, 98.75% ± 0.15% de AyG, 99.58% ± 0.04 de SST, 99.83% ± 0.01 de DBO y pH de 7.03 ± 0.06; por otro lado, el FC fue decreciendo en su eficiencia de remoción de 91.81% ± 0.17% de DQO, 92.16% ± 0.41% de A y G, 99.24% ± 0.08% de SST, 99.76% ± 0.02% de DBO y pH 7.50 ± 0.10. Se confirmó que ambos tratamientos cumplen con los parámetros establecidos en el D.S 010-2019-VIVIENDA (VMA); asimismo, se atribuye que la eficiencia del VF se debe directamente a la lombriz Eisenia fetida.
Study of urban sprawl using the built-up area extraction map and supervised classification Case Study Wilaya of Tizi-Ouzou, Algeria *
Authors: arab nabil amine
Published: November 2022

The objective of our study is to evaluate the phenomenon of urbanization in the wilaya of Tizi-Ouzou through two distinct methods, the first method is to generate a map of extraction of built-up areas (BAEMOLI) from the calculation of the index of normalized difference of the built-up NDBI OLI, the index of vegetation NDVI OLI and the modified index of normalized difference of the water MNDWI OLI, and the second method is to use the supervised classification has different period 1987, 2000, 2009, 2019 and 2021, we start with the first method in order to have a visual overview of the urban growth in the different regions of the wilaya of Tizi-Ouzou, and in knowledge of the limitations of the first method which certainly allows to have an approximate and global overview of the phenomenon to study something which is primordial to have a methodical approach of the phenomenon which rages in the wilaya and these regions, but which unfortunately does not make it possible to make the distinction between the bare grounds and the urban zones, thing which pushed us has used a second complementary method, that of the supervised classification in order to add a more detailed study by quantifying this urbanization, with figures and statistics which make it possible to analyze the phenomenon of urbanization with much more precision, and end up with explanations and interpretations drawn from past studies made on the six regions of the wilaya of Tizi-Ouzou
BMI across adulthood, COVID-19 and long COVID in two British birth cohorts
Authors: Staatz Charis Bridger , Bann David , Ploubidis George , Goodman Alissa , Silverwood Richard
Published: November 2022

Longer exposure to obesity, and thus a longer period in an inflamed state, may increase susceptibility to infectious diseases and worsen severity. Previous cross-sectional work finds higher BMI is related to worse COVID-19 outcomes, but less is known about associations with BMI across adulthood. To examine this, we used body mass index (BMI) collected through adulthood in the 1958 National Child Development Study (NCDS) and the 1970 British Cohort Study (BCS70). Participants were grouped by the age they were first overweight (> 25kg/m2) and obese (> 30kg/m2). Logistic regression was used to assess associations with COVID-19 (self-reported and serology-confirmed), severity (hospital admission and contact with health services) and long-COVID reported at ages 62 (NCDS) and 50 (BCS70). Longer exposure to obesity was associated with increased odds of adverse COVID-19 outcomes, but results were mixed and often underpowered. Those with early exposure to obesity were over twice as likely in NCDS (odds ratio (OR) 2.15, 95% confidence interval (CI): 1.17 to 4.00) and three times as likely in BCS70 (OR 3.01, 95% CI: 1.74 to 5.22) to have long COVID. In NCDS they were also over four times as likely to be admitted to hospital (OR 4.69, 95% CI: 1.64 to 13.39). Most associations were somewhat explained by contemporaneous BMI or reported health, diabetes or hypertension; however, the association with hospital admission in NCDS remained. An earlier age of obesity onset is related to COVID-19 outcomes in later life, providing evidence on the long-term impact of raised BMI on infectious disease outcomes in midlife.
Zyxin promotes hepatocellular carcinoma progression via activation the AKT/mTOR signaling pathway
Authors: Cai Tianying , Bai Junjie , Tan Peng , Huang Zhiwei , Liu Chen , Wu Ziming , Cheng Yonglang , Li Tongxi , Chen Yifan , Ruan Jian , Gao Lin , Du Yichao , Fu Wenguang
Published: November 2022

To investigate the regulatory effect and specific mechanism of the actin-interacting protein zyxin (ZYX) in hepatocellular carcinoma (HCC). HCC is one of the most common malignant tumors in the world which occurrence and development areregulated by multiple genes. We found that the expression of ZYX in HCC tissues was significantly higher than that in normal liver tissues. The results of cell proliferation assay, scratch test and transwell assay showed that high expression of ZYX promoted the proliferation, migration and invasion of hepatoma cell lines (PLC/PRF/5, HCCLM3), inhibiting the expression of ZYX reduced the proliferation, migration, and invasion of hepatoma cells(SK HEP-1, Huh-7). Further analysis found that the expression of cell cycle-related proteins, cell migration and invasion-related proteins were changed when the expression of ZYX changed. Xenograft models showed similar results. The AKT/mTOR signaling pathway is a classic pathway ofcancer development. We found that the phosphorylation level of AKT/mTOR protein was up-regulated with increasing ZYX expression and down-regulated with decreasing ZYX expression. While the addition of the AKT inhibitor MK2206 counteracted the proliferation, migration and invasion of HCC cells with increasing ZYX expression, the AKT activator SC79 also restored the proliferation, migration and invasion of HCC cells with decreasing ZYX expression. Therefore, we speculate that the expression of ZYX may promoting the progression of HCC by activating AKT/mTOR signaling pathway, thereby. This is also the first time to find the mechanism of ZYX in HCC, indicating that ZYX is a possible new target for HCC treatment.
A Case Report: Pulmonary Embolism (PE) in Hemodialysis Patients with Autogenous Arteriovenous Fistula (AVF) Occlusion during Ultrasonography
Authors: Zhu Xiaohua , Zhu Hong , Ding Zhihui , Yao Chunlei , Qian Houlong
Published: November 2022

Backgrounds: Symptomatic pulmonary embolism is rare and fatal. We report a case of a patient with fatal pulmonary embolism during ultrasonography examination of autogenous arteriovenous fistula.
Case presentation: We present the case of a 53-year-old woman with end-stage renal disease (ESRD). The left forearm arteriovenous fistula is the vascular access. After had maintenance hemodialysis for about 9 years, the patient developed an aneurysm behind the anastomosis. She visited the doctor after finding that the arteriovenous fistula tremor disappeared. During the ultrasound examination, the patient lost consciousness. Pulmonary embolism was confirmed by enhanced CT. The patient was improved after tracheal intubation and active anticoagulation therapy. The follow-up angiography showed arteriovenous fistula anastomotic stenosis, autologous arteriovenous reconstruction surgery was performed.
Conclusions: Symptomatic and fatal pulmonary embolism was rarely during ultrasonography examination of autogenous arteriovenous fistula. Therefore, clinicians should pay attention to this possibility to provide timely and appropriate treatment.
Identification of Myelodysplastic Syndrome Risk-related Genes and their Association with Immune Infiltration
Authors: Wang Wenqian , Fu Rong , Cui Daizheng , Yao Deyang , Wu Zhihua , Xie Wei , Li Chengyu , She Xinyi , Xin Hanchang , Song Xiaohang , Zeng Tiansheng , Ye Xu
Published: November 2022

Objective
Myelodysplastic syndrome (MDS) is a hematological malignancy. Recently, immune cells participate in the occurrence and progression of various tumors has revealed by many researches. In this study, we investigated the correlation between the expression levels of MDS risk-related genes and the ratio of tumor-infiltrating immune cells in CD34+ cells. Our research may provide some help for the basis of the pathogenesis of MDS and the prognosis analysis of patients.
Methods
This research was based on two microarray datasets GSE19429 and GSE58831. The differential expressed genes (DEGs) of low risk vs. high risk MDS were analyzed by GEO2R. The GO and KEGG pathways of DEGs were identified by enrichment analysis. Three risk-related genes were screened and identified by LASSO analysis and MCC algorithm. Then, the tumor immune cell infiltration of CD34+ cells in MDS patients were analyzed by CIBERSORT to define the differences in tumor immune cell infiltration between low-risk and high-risk MDS.
Results
We collected 179 transcriptomes and 159 transcriptomes from dataset GSE58831and GSE19429. We found that low-risk and high-risk MDS patients had significant differences in prognosis. Besides, 105 common DEGs was identified in both datasets, which were mainly enriched in malaria, African trypanosomiasis, transcriptional dysregulation in cancer, phagosome, and primary immunodeficiency in the KEGG pathway. Three risk-related genes were screened by LASSO analysis and MCC algorithm: CDC6, RRM2, HMMR. There was a significant difference in the prognosis between the high-risk group and the low-risk group differentiated by these 3 gene markers. In addition, Treg, mast cells, CD8+ T cells, Macrophage M2, Eosinophils and Neutrophils were also found significantly difference between low-risk and high-risk MDS in tumor immune cell infiltration (P < 0.05). Also, three risk-related genes and tumor immune cells were significantly correlated.
Conclusion
We screened out three risk-related genes in MDS. CDC6, HMMR and RRM2 are highly expressed in the low-risk group of MDS and low in the high-risk group, and the expression levels of the three genes are closely related to the infiltration of various immune cells. This conclusion has potential clinical prognostic value for MDS patients.
Transcription analysis of the THBS2 gene through regulation by potential non-coding diagnostic biomarkers and oncogenes of gastric cancer in the ECM receptor interaction signaling pathway: integrated systems biology and experimental investigation
Authors: Barani Ali , Beikverdi Kamyar , Mashhadi Benyamin , Parsapour Naeimeh , Rezaei Mohammad , Javid Pegah , Azadeh Mansoureh
Published: November 2022

Background
Gastric cancer (GC) is the second most frequent cause of cancer-related death worldwide and the fourth most common malignancy. Despite significant improvements in patient survival over the past few decades, the prognosis for patients with GC remains dismal because of the high recurrence rate. In this comprehensive systems biology and experimental investigation, we aimed to find new novel diagnostic biomarkers of GC through a regulatory RNA interaction network.
Methods
Gene expression, co-expression, and survival analyses were performed using microarray and RNAseq datasets (analyzed by R Studio, GEPIA2, and ENCORI). RNA interaction analysis was performed using miRWalk and ENCORI online databases. Gene set enrichment analysis (GSEA) was performed to find related signaling pathways of up and down-regulated genes in the microarray dataset. Gene ontology and pathway enrichment analysis were performed by the enrichr database. Protein interaction analysis was performed by STRING online database. Validation of expression and co-expression analyses was performed using a qRT-PCR experiment.
Results
Based on bioinformatics analyses, THBS2 (FC: 7.14, FDR < 0.0001) has a significantly high expression in GC samples. lncRNAs BAIAP2-AS1, TSIX, and LINC01215 have RNA interaction with THBS2. BAIAP2-AS1 (FC: 1.44, FDR: 0.018), TSIX (FC: 1.34, FDR: 0.038), and LINC01215 (FC: 1.19, FDR: 0.046) have significant up-regulation in GC samples. THBS2 has a significant role in the regulation of the ECM-receptor signaling pathway. miR-4677-5p has a significant RNA interaction with THBS2. The expression level of THBS2, BAIAP2-AS1, TSIX, and LINC01215 has a non-significant negative correlation with the survival rate of GC patients (HR: 0.28, logrank p: 0.28). qRT-PCR experiment validates mentioned bioinformatics expression analyses. BAIAP2-AS1 (AUC: 0.7136, p-value: 0.0096), TSIX (AUC: 0.7456, p-value: 0.0029), and LINC01215 (AUC: 0.7872, p-value: 0.0005) could be acceptable diagnostic biomarkers of GC.
Conclusion
BAIAP2-AS1, lncRNA LINC01215, lncRNA TSIX and miR-4677-5p might modulate the ECM-receptor signaling pathway via regulation of THBS2 expression level, as the high-expressed non-coding RNAs in GC. Furthermore, mentioned lncRNAs could be considered potential diagnostic biomarkers of GC.
Quantitative profiling of DNA 6mA at single-base resolution using NAME-seq
Authors: Li Xuwen , Zhang Zijian , Yin Jiekai , Luo Xinlong , Wang Yinsheng , Wu Tao
Published: November 2022

DNA N6-methyladenine (6mA) is prokaryotes' most prevalent type of DNA methylation. Recently, 6mA has been identified in eukaryotic genomes, but the prevalence of 6mA in eukaryotes has been debated due to the limitations of current 6mA genomic profiling and quantification methods. To solve the challenges, we develop a chemical-based sequencing method, Nitrite-assisted Amino MEthylation sequencing (NAME-seq), for genomic profiling and single-base quantification of DNA N6-adenine methylation rate. NAME-seq combines nitrite conversion of 6mA to nitrosylated-6mA (6mA-NO) with Klenow fragment (3'→5' exo−) mediated DNA synthesis to induce the 6mA-to-T transversion specifically. We apply NAME-seq to bacterial and eukaryotic genomes; NAME-seq can accurately map 6mA and quantify the ratio at single-base resolution. Moreover, we show that NAME-seq can be applied with 6mA-MeDIP-seq to map 6mA in the human genome and improve accuracy. In summary, NAME-seq is an efficient method for quantitative 6mA mapping at single-base resolution.
Analysis of the causes of pedestrian-vehicle traffic accidents based on Bayesian networks
Authors: Yang Jianjun , Lai Yu , Shi Hongbo , Chen Yimeng
Published: November 2022

With the continuous improvement of people's living standards, the number of cars has also increased dramatically. While cars are convenient for people to travel, they also lead to increasingly serious traffic safety problems. For this reason, this paper uses the fault tree and Bayesian network methods to conduct an in-depth study on the causes of pedestrian-vehicle traffic accidents from three aspects: people, vehicle, road and the environment. In this paper, the occurrence of pedestrian-vehicle traffic accidents is divided into 29 basic events. The basic events of each of the 381 pedestrian-vehicle traffic accidents were Classified by 0–1. A fault tree model leading to pedestrian-vehicle traffic accidents is established, which is then transformed into a Bayesian network model, and Bayesian network inference, sensitivity analysis is performed with the help of Netica software. Our results suggest that illegal crossing of traffic lanes, speeding, rainy day, slippery road, braking is not timely, visual impairment are the main causes of pedestrian-vehicle traffic accidents. These results can not only provide a reference for transportation technology, but also provide a basis for government legislation.
Effects of simulated gut pH environment on gut bacterial pheromone production of Dendroctonus valens (LeConte)
Authors: Zhao Yu , Koski Tuuli-Marjaana , Li Huiping , Sun Jianghua , Cao Qingjie
Published: November 2022

Bark beetles are economically and ecologically important insect group, which aggregation behavior and thus host colonization success depended on pheromone-mediated communication. For some species, such as for the major invasive forest pest in China, red turpentine beetle (Dendroctonus valens), gut microbiota participates in pheromone production by converting tree monoterpenes into pheromone products. However, how variation in gut microenvironment, such as pH, affects the gut microbial composition, and consequently pheromone production, is unknown. In this study, we fed wild caught D. valens with three different pH mediums (main host diet with natural pH of 4.7; a mildly acidic diet with pH 6 mimicking the beetle’s gut pH; and highly acidic diet with pH 4), and measured their effects on the gut pH, gut bacterial community and production of the main aggregation and anti-aggregation pheromone (verbenone). We further tested the verbenone production capacity of two gut bacterial isolates in different pH environments (pH 6 and 4). Compared to natural state or main host diet, feeding on less acidic diet (pH 6) diluted the gut’s acidity, whereas feeding on highly acidic diet (pH 4) enhanced it. Both changes in gut pH reduced the abundance of dominant bacterial genera, resulting in degrease in verbenone production. Similarly, the highest pheromone conversion rate of the bacterial isolates was observed in pH mimicking the acidity in beetle gut. Taken together, these results indicate that changes in gut pH can affect gut microbiota composition and pheromone production, and may therefore have the potential to affect host colonization behavior.
Atomic-Scale Observation of Stacking Domain Structures in a Semiconducting Van Der Waals Ferrovalley Material VAgP2Se6
Authors: Miao Leixin , Lee Seng Huat , He Jingyang , Gopalan Venkatraman , Mao Zhiqiang , Alem Nasim
Published: November 2022

The van der Waals (vdW) ferrovalley materials show spontaneous valley polarization without external tuning by simultaneously possessing the valley degree of freedom and the broken time-reversal symmetry but are extremely rare. The ferrovalley crystals with spin-orbital coupling are predicted to generate novel quantum phenomena in two-dimensional thin layers, such as the anomalous valley Hall effect. However, due to the reduced symmetry, a potential issue in vdW ferrovalley materials is their complex domain structures. Here, we report domain structure studies in a semiconducting vdW ferrovalley material VAgP2Se6. Our studies reveal clear evidence of second harmonic generation (SHG) response and magnetic hysteresis loop in the bulk VAgP2Se6 crystals suggesting spontaneously broken inversion and time-reversal symmetry. We image its domain structures directly at atomic resolution using aberration-corrected scanning transmission electron microscopy (AC-STEM). Six variants of domains stacking along the c-axis are observed and can be well understood via group theory analysis. The domain structures of vdW materials can create naturally occurring heterostructures that could alter the electronic structures and may lead to topological interfacial states but have not been explored extensively. Our findings open the possibilities for observing and understanding exotic quantum phenomena in vdW ferrovalley materials by engineering the domain structures.
Comprehensive Analysis Uncovers Prognostic and Immunogenic Characteristics of Cellular Senescence for Gliomas
Authors: Sun Zhaohui , Wang Zerong , Zheng Xiaonan
Published: November 2022

Background
Cellular senescence is considered to be an important correlate of tumorigenesis and progression, but the correlation between cellular senescence and immune infiltration of tumors remains unclear in glioma. The prognostic value of cellular senescence in gliomas with immune infiltration needs further investigation.
Methods
We obtained data from TCGA for GBM patients and LGG patients, followed by screening these genes by LASSO-COX based on genes associated with cellular senescence obtained from CellAge thereby obtaining survival-related signature genes, followed by KM analysis, ROC analysis, PCA analysis and immunostaining profiles to verify the risk score as a prognostic indicator of independence and plotting bar lines, and exploring the biological pathways associated with the high-risk group by GSEA analysis. The signature was also validated by combining the genetic information obtained from the China Glioma Genome Atlas (CGGA) database for GBM patients and LGG patients.
Results
We constructed a prognostic signature for five cellular senescence-related genes. They were CENPA, IGFBP-5, TNFSF13, PATZ1 & CDK6. The independence of the risk score as a prognostic indicator was validated by KM analysis, ROC analysis, PCA analysis, and immunohistochemical results. The prognosis of glioma patients was established from a plotted nomogram. We then found that the high-risk group was significantly enriched for pathways in the cell cycle, nuclear division regulation, CD40 signalling pathway and p53 signalling pathway by GSEA analysis. ssGSEA results indicated that the high-risk group was associated with tumor-infiltrating immune cells, including MDSCs, macrophages and Tregs.
Conclusions
We analyzed the clinical significance of different risk groups on glioma prognosis and the role in the immune landscape by constructing an independent prognostic signature based on cellular senescence correlation, which may help to develop personalized immunotherapy strategies for oncologists.
Development and validation of a clinical model to estimate the probability of frailty in older emergency patients
Authors: Li Junyu , Wang Guodong , Liu Huizhen , Shang Na , Wang Na , Guo Shu-Bin
Published: November 2022

Objectives
Most instruments to measure frailty are impractical to operationalize in emergency department (ED), due to the busy work of the staff and the acute presentations of the patients. The current work aimed to develop and validate a clinical model by combining clinical data and biomarkers available in the ED to evaluate the probability of frailty among older emergency patients.
Design:
A cross-sectional research.
Setting and participants:
A total of 273 adults aged 65 years and older who visited the ED of a university-affiliated hospital in Beijing, China during the period from January 2021 to September 2021 were included.
Measurements:
Fried's frailty phenotype was employed for assessing frailty. Clinical data and blood biomarkers were collected within 24 hours of admission. Clinical data included demographic characteristics, chronic diseases, main causes of admission and nutrition risk screening (NRS) 2002 score. Blood biomarkers included hallmarks of inflammation, nutrition and metabolism, coagulation and other biomarkers such as alanine transaminase (ALT), aspartate transaminase (AST), N-terminal pro-brain natriuretic peptide (NT-pro-BNP), and creatinine.
Results
Totally 151 patients were frail. Eight variables were included in the diagnosis model: nutritional risk, prior ischemic heart disease (IHD), age > 77 years, ALT ≤ 9.2 U/L, albumin ≤ 31.9 g/L, homocysteine > 18 umol/L, 25-OH vitamin D ≤ 10.89 ng/mL, and NT-pro-BNP > 2070 ng/L. Through the area under receiver operating characteristics curve (AUC) (0.855), leave-one-out cross-validation (AUC = 0.828), as well as Hosmer-Lemeshow test (P = 0.615), the validity of the diagnosis model was verified. The clinical diagnosis model was converted into a scale score with a total score of 10. The AUC of the diagnostic score for predicting frailty was 0.851 (95% confidence interval: 0.806–0.895, P< 0.001) and the cutoff value was 4.5 points with the Youden index of 0.579. Following adjustment for gender and main causes of admission, the diagnostic score was an independent predictor for 28-day mortality, with a hazard ratio of 1.486 and a 95% confidence interval of 1.224–1.804 (P < 0.001).
Conclusion
In the current work, a clinical diagnosis model to estimate the probability of frailty in older emergency patients was developed using clinical data and biomarkers generally readily available in the ED. This diagnosis model may facilitate targeted intervention and risk stratification in the EDs.
The Role and Place of Nitroxidergic Regulation of The Endothelial System in the Pathogenesis of Acute Lung Abscess
Authors: Okhunov A.O. , Bobokulova Sh.A.
Published: November 2022

Background. Purulent-destructive lung diseases remain a priority among the causes of generalized infection and death. The key to the progression of infection in acute lung abscesses may be associated with impaired barrier-filtration function of this organ, which is based on endothelial dysfunction.
Methods. The experiments were carried out on 32 Chinchilla rabbits, in which the model of acute lung abscess was reproduced. Investigated in blood samples at the entrance and exit from the lungs, such indicators as nitrates, nitrites, peroxynitrite, NO-synthase and von Willebrand factor.
Conclusion. Nitric oxide produced because of iNOS activation is intended for non-specific protection of the body against a wide range of pathogenic agents, inhibits platelet aggregation and improves local blood circulation. However, these changes do not occur. The main role in this direction is assigned to peroxynitrite, which, due to its pathogenicity, worsens the already process associated with endothelial dysfunction. The nature of the changes in the parameters of the nitroxidergic regulation of the endothelial system in the lungs has a staging: compensated and decompensated. All this is of a natural nature, based on certain relationships between the indicators of the nitroxidergic regulation system.
Reinforcing Indigenous Peoples’ Right to Health in the Wake of the COVID-19 Pandemic: A Panacea for Sustainable Human Rights Protection
Authors: Nnawulezi U. , Nwaechefu H.
Published: November 2022

The rights of indigenous peoples have become an important issue of international law and policy over the past three decades as a result of movements led by indigenous peoples, civil society, international mechanisms and states at the domestic, regional and international levels. Indigenous peoples are widely recognized as being among the world’s most vulnerable, disadvantaged and marginalized peoples. In order to identify, recognize and protect the rights of indigenous peoples, it is necessary to have a clear understanding of who the indigenous people are. Moreover, the definition that is derived cannot be static, but must change with the times and from place to place as well as adapt to the changing circumstances and environments. This paper analyses the statutory definitions of indigenous peoples and their rights as provided under the United Nations legal framework and other regional frameworks. Furthermore, it examines the unique perspectives on health held by indigenous peoples as well as their vulnerability to the COVID-19 pandemic. The question that was posed in this paper, however, was whether the right to health extends to indigenous peoples, thereby making it binding on a far greater number of actors. And what are the issues that pertain to the human rights of indigenous peoples. Nevertheless, this paper noted that the United Nations Human Rights System, as well as its mechanisms, laws and policies have been at the heart of these developments. This paper takes an analytical and qualitative approach to its research and builds its argument on existing literature, which is achieved through a synthesis of ideas. The paper concludes that the rights of indigenous peoples are increasingly being formally incorporated into the domestic legal systems of various countries.
Transformation of the Concept of Administrative Liability in the Protection of the Rights, Legitimate Interests and Security of Citizens
Authors: Panteleev V.
Published: November 2022

This article discusses key areas of harmonization of administrative legislation and administrative responsibility between the Russian Federation and the Eurasian Economic Union (EAEU) countries. The most important issue in modern law is understanding that the uniform practical application of consistent administrative liability will enable the creation of a customs, tax, technological, and environmental space in the EAEU and BRICS. The author, on the basis of the findings of other researchers, gives an original definition of legal and administrative liability, which can be used in the harmonization of Russian legislation with the legislation of other BRICS and EAEU countries. The author also determines the regulation of the administrative process and the difference between administrative liability and other types of legal liability in accordance with modern Russian legislation.
Contribuições da pedagogia waratiana para a predominância das metodologias ativas de ensino jurídico
Authors: Viana Andrade Caio , Nogueira Rebouças Marcus Vincius , Pereira Junior Antonio Jorge
Published: November 2022

O objetivo do presente artigo é responder ao seguinte questionamento: em que medida a pedagogia emancipatória do Direito, desenvolvida por Luis Alberto Warat, poderá contribuir para a preeminência das metodologias ativas de ensino jurídico existentes? Parte-se do pressuposto de que o ensino jurídico brasileiro ainda se encontra distante das dimensões fáticas e axiológicas do Direito, uma vez que a metodologia predominante prioriza a sua dimensão normativa. Inúmeras são as soluções oferecidas para contornar o referido problema, todavia, dificilmente encontram-se propostas pedagógicas capazes de enfrentá-lo em raiz. Para isso, pretende-se analisar uma proposta alternativa e complementar: a pedagogia emancipatória do Direito, cujo o escopo é ressignificar epistemologicamente e sociologicamente o ensino jurídico. A metodologia utilizada foi a investigação do tipo bibliográfica e documental, com pesquisa expositiva de abordagem qualitativa e explicativa, tendo como método o hipotético-dedutivo. Concluiu-se que o ensino jurídico carnavalizado e surrealista – modelos de ensino originados da pedagogia emancipatória do Direito –, quando aliados às metodologias ativas, possibilitam, em alguma medida, a superação de três fortes obstáculos à adoção: a) rigidez do ambiente acadêmico; b) visão dedutiva do Direito; e c) prevalência de métodos passivos de ensino.
Resenha do livro de Fábio Portela Lopes. Constitution: The Darwinian Evolution of a Societal Structure
Authors: Elmauer Douglas
Published: November 2022

Resenha: Almeida, Fábio Portela Lopes de (2020). Constitution: The Darwinian Evolution of a Societal Structure. 1. ed. Baden-Baden: Nomos, 2020.
Apresentação
Authors: Stamford da Silva Artur , Moita Edvaldo
Published: November 2022

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Teorias raciais como jurisprudência narrativa
Authors: Costa Frederico Magalhães
Published: November 2022

O presente artigo se vale do modelo teórico-literário da jurisprudence as narrative esboçado por Robin West (1985) para observar o Direito como um objeto estético, no sentido de explorar novas perspectivas de análise narrativa a partir de teorias da raça. Trata-se de uma pesquisa teórica e exploratória em que a revisão bibliográfica foi utilizada para analisar autores e teorias literárias, da raça e do Direito. A partir da investigação realizada foi possível observar o caráter multifacetado das teorias raciais e verificar que elas dialogam diretamente com teorias do direito e teorias literárias.
Assessing School Community Involvement in Implementing School Summary Report Cards A Case study of Mpanda District in Katavi Region, Tanzania
Authors: Adam Mwajabu , Osaki Kalafunja
Published: November 2022

We describe here a study that assessed school community involvement in implementing a School Summary Report Card (SSRC) in public secondary schools: in Mpanda District in Katavi Region, Tanzania. The study had three specific objectives, which were to evaluate the awareness of the school community in the implementation of SSRC in school progress, examine the level of community participation in the implementation of SSRC, and explore the challenges of implementing SSRC. The study was guided by an open systems theory which originated from the General System Theory and approach by Ludwing Von Bertalanffy, in 1950s after World War II (Scott & Davis, 2016). Data were collected through questionnaires to 45 teachers; interviews with 5 heads of schools, 3 Ward Educational Officers, and 1 District School Quality Assurance Officer. Focused Group Discussions were conducted with 50 students and 35 community members. We also performed school observation and documents review. Descriptive statistics and thematic analysis were used to analyze the data. The findings indicate that the majority of the teachers and community members were not made aware of the use of SSRC. Low involvement of the school community members in the implementation of SSRC and also there varying interpretations of common symbols in the SSRC and mismatch between ratings of the SSRC indicators and the final valuation of the SSRC. The study recommends the conduction of a broader sensitization of the school community on what constitutes SSRC, and how to implement it to bring about an impact on the school and community
Monitoring Employers of the Degree in Human and Rehabilitation Acupuncture in the Labor Market
Authors: Anaisbeth Osorio Medrano Iris , Angélica Castañeda Duarte , Emma López Espinosa , Yolanda García Piceno , Ledesma Eduardo Salazar
Published: November 2022

Acupuncture is a therapeutic clinical medical model, a branch of Traditional Chinese Medicine, in which filiform metal needles are used on the surface of the body to balance, prevent, recover and rehabilitate the individual according to NOM - 017 - SSA3 - 2012. In In recent years, in addition to unemployment, a series of distortions have appeared in the labor market for professionals. This work seeks to contribute to the analysis of said market using data from a survey of graduates and employers of said graduates, from a state public university in Mexico. From them, an indicator of relevance in the labor market is designed. The results show that a significant proportion of professionals work in inadequate conditions and that there is great heterogeneity in terms of the situation of said market . OBJECTIVE: To advance in the study of this dimension of relevance by analyzing the labor market for professionals through the integration of a series of characteristics, which in the previously reviewed studies were reflected separately, so that a more complete knowledge of how professionals are inserted into said market and the opinion of their employers, using data from a survey of graduates and employers. METHODOLOGY. Job placement surveys: carried out within the second and fifth year after graduation, designed to characterize the process of job placement, completion of studies and institutional satisfaction. RESULTS A survey was conducted of 15 employers of graduates of the Human and Rehabilitative Acupuncture degree, from the centers that have been hiring LAHR graduates for 10 years, while the response recently refers to a hiring period of less than one year. Our surveyed employers take 95% of academic preparation as a fundamental part of hiring a LAHR graduate. Employers need graduates to have theoretical and practical knowledge of traditional Chinese medicine, followed by knowledge of physical means focused on rehabilitation. Conclusions: According to the respondents, we observed the great need to have an agenda for the graduate clinics, to have a greater number of samples and standardize the suggestion
Aplicación de experiencias adquiridas en el Sistema Universidad Abierta
Authors: Arvizu Tovar Laura Olivia
Published: November 2022

Tengo 30 años de egresada y he laborado en gobiernos estatales y federales relacionados con la salud pública, la sanidad y producción animal. He impartido cursos de capacitación a servidores públicos y desde el año 2004 empecé a dar clases como profesora de asignatura; a partir de agosto de 2014 me incorporé de tiempo completo como profesora de licenciatura y posgrado en la Facultad de Medicina Veterinaria y Zootecnia de la Universidad Nacional Autónoma de México (unam). La asignatura que imparto en licenciatura es Marco Legal de la Medicina Veterinaria y Zootecnia, el principal reto como docente con el alumnado es romper el paradigma ya que piensan que requieren aprender de animales, enfermedades, pero no de legislación; sin embargo, aplicó lo que aprendí de mis maestros del Sistema de Universidad Abierta (sua) quienes hábilmente combinaban la teoría con la práctica al presentarnos ejemplos de la vida real y así identifiquen la utilidad que tiene. En este podcast comparto las experiencias adquiridas.
Experiencia de un Sistema de Universidad Abierta y a Distancia en Medicina Veterinaria
Authors: Tellez Reyes Retana Eduardo Ramon
Published: November 2022

El objetivo de este podcast es compartir la experiencia y la responsabilidad que tuve para el diseño del Sistema de Universidad Abierta y Educación a Distancia (suayed), tanto en la Facultad de Medicina Veterinaria y Zootecnia (fvmz) como a nivel Universidad; y por qué además creo firmemente que el sistema efectivamente funciona para la capacitación y educación de profesionales que necesita el país.
Síndrome de apnea-hipopnea obstructiva del sueño en pacientes postoperados de cateterismo cardiaco
Authors: Méndez Saucedo Luis Miguel , Serrano Salinas Laura , Mancilla Mejía Francisco Javier , Hernández Mundo Abraham , Díaz González Daniel Alejandro
Published: November 2022

The prevalence of obstructive sleep apnea-hypopnea syndrome (OSA) is up to 10%, and it can present systemic complications, such as cardiovascular ones. In the adult population, ischemic heart disease remains one of the leading causes of mortality. There are reports in the world medical literature in which there is a high correlation of OSA in patients who have presented acute coronary syndrome (ACS), these studies have been done in populations with physical and sociodemographic characteristics different from those of our population. There is a high correlation (prevalence 100%) between OSA and ACS, where the most prevalent is the degree of severe intensity. The risk factors that demonstrate a high prevalence in the population studied, atherosclerosis, dyslipidemia and systemic arterial hypertension, sedentary lifestyle, smoking, type 2 diabetes mellitus and alcoholism. Keywords: OSA; obstructive sleep apnea; acute coronary syndrome; polysomnography