bluuebunny/crossref_metadata_2025 huggingface dataset:
Neutrophil activation at high-fat high-cholesterol and high-fructose diets induces low-grade inflammation in mice
Authors:   Department of Histology, Cytology and Embryology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine, Bila G. , Vishchur O. ,   Institute of Animal Biology NAAS, Lviv, Ukraine;, Vovk V. ,   Department of Pathological Anatomy and Forensic Medicine, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine;, Vari S. ,   International Research and Innovation in Medicine Program, Cedars-Sinai Medical Center, Los Angeles, California, USA;, Bilyy R. ,   Department of Histology, Cytology and Embryology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine;
Published: April 2024

Nonalcoholic fatty liver disease (NAFLD), which can progress to nonalcoholic steatohepatitis (NASH), is a significant health concern affecting a substantial portion of the population. This study investigates the role of neutrophil extracellular traps (NETs) in liver inflammation induced by high-fat high-cholesterol diet (HFHCD) and high-fructose diet (HFD). The chronic nature of NAFLD involves low-grade inflammation with cytokine elevation. The research aims to visualize neutrophil elastase (NE) activity during HFHCD and HFD representing conditions of low-grade activation and assess neutrophil functional status. The study employs a mouse model subjecting animals to HFHCD, HFD or a standard diet (SD) for six weeks. Various analyses were used including histological evaluations, in vivo imaging of NE activity using a fluorescent probe, fluorescent microscopy, flow cytometry and assessment of neutrophil function through reactive oxygen species (ROS) levels. Mice on HFHCD and HFD display liver damage consistent with NASH, which was validated pathohistologically. NE activity in blood significantly increases after six weeks indicating systemic NETs involvement. In vivo imaging confirms NE activity in multiple organs. Cellular localization reveals NETs persistence even after neutrophil destruction in splenocytes indicating systemic involvement. Neutrophils under HFHCD exhibit a functional phenotype associated with low-grade inflammation, higher basal ROS levels and reduced activation potential. This study establishes the systemic impact of NETs in HFHCD- and HFD-induced liver inflammation, providing insights into the functional state of neutrophils. The findings contribute to understanding the mechanisms underlying chronic liver conditions and may inform future therapeutic strategies. Keywords: high fat diet, in vivo imaging, low-grade inflammation, NASH, neutrophil elastase, neutrophil extracellular traps, neutrophils
Personnel selection system based on the selection algorithm
Authors: Quintanilla-Medina Maria del Carmen Veronica , Coral-Ignacio Marco Antonio
Published: April 2024

The evolution of personnel selection systems has been driven by technological advances and changes in the needs of organizations, referring to the set of processes and tools used by an organization to evaluate and select the most suitable applicants to fill a position within the company, in order to ensure that people with the skills, knowledge and competencies necessary to perform the responsibilities and functions associated with the position are hired. It is therefore proposed to implement a personnel selection system, which will help optimize the recruitment and selection process using the competency model and the selection algorithm to choose the best candidates according to the selection criteria established for each job position, resulting in the best candidates for the position with the qualities for which they were chosen.
Desempeño de una vía no pavimentada reforzada con geomalla: construcción de un modelo físico en laboratorio y validación numérica
Authors: Bastidas-Martínez Juan Gabriel , Herrera-Cano Camilo Ernesto , Bautista-Tapias Howen Jair
Published: April 2024

Este estudio evaluó el comportamiento mecánico de un modelo físico laboratorial de una vía no pavimentada reforzada con una geomalla biaxial GB. Para tal fin, se compactaron 0.15 m de material de mejoramiento y 0.20 m de subrasante en una caja cuadrada de 0.35 m. Se realizaron ensayos con y sin refuerzo, mediante la aplicación de 10000 ciclos de carga dinámica en una maquina universal. Se utilizo una frecuencia de 2.5 Hz y presión de 560 kPa mediante una placa circular de 0.10 m de diámetro, simulando la circulación de una llanta de un eje rueda simple. La validación numérica vía Métodos de los Elementos Finitos (MEF) definió parámetros usando el modelo Hardening Soil. Como gran conclusión, se pudo evidenciar que el refuerzo con una geomalla reduce aproximadamente 45% la magnitud del ahuellamiento, según el modelo, debido a que la geomalla reduce la concentración de esfuerzos cortantes (τ relativo) disminuyendo la deformación plástica.
Editorial N.º 91
Authors: Castañeda-Rodríguez Víctor Mauricio
Published: April 2024

Inicio este editorial, la última que escribo como editor saliente de la revista Innovar, agradeciendo a la administración de la Facultad de Ciencias Económicas de la Universidad Nacional de Colombia por la confianza que depositaron en mí para dirigirla en los últimos seis años. Además del honor que esto me significó, también constituyó un espacio de aprendizaje y una oportunidad para aportar mi grano de arena en la consolidación de la revista. Quisiera, asimismo, desearle éxitos al profesor Juan Javier Saavedra Mayorga en la gestión que inicia como editor en jefe de Innovar. Creo que las características de la comunidad académica conformada alrededor de esta publicación, además de las cualidades profesionales y personales de su equipo editorial, serán un apoyo invaluable para la gestión del profesor Javier.
John Naish’s contribution to the literature and history of the Queensland canefields
Authors: Taylor Cheryl , Vidonja Balanzategui Bianka
Published: April 2024

Welsh-born author and playwright John Naish worked and wrote on the North Queensland canefields between 1950 and 1963. Assisted by unpublished works, letters and diaries shared by the Naish family, this study outlines the full contents of Naish’s known oeuvre for the first time. It focuses on the depiction of canefield labour and society in two novels, an autobiographical piece and five plays – some newly discovered. Attitudes in his writings to sugar country class divisions, to workers and their rights, to canefield labour and labourers, to gender divisions and conflicts in the towns and fields, to race, Indigenous Australians and to British and Italian immigrants are exemplified and examined. Extensive evidence supports the conclusion that Naish was a liberal and compassionate thinker. Always competent and sometimes powerful as literature, together his works comprise an authentic socio-historical document.
Materiales arqueológicos de la colección Gutiérrez Achútegui en el discurso expositivo del Museo de la Romanización de La Rioja en Calahorra
Authors: Luezas-Pascual Rosa-Aurora
Published: April 2024

A principios del siglo pasado un erudito calagurritano Pedro Gutiérrez Achútegui comenzó a formar una colección de materiales arqueológicos a la que pertenecen las piezas objeto de este estudio, que se encuentran integradas actualmente en el Museo de la Romanización de La Rioja en Calahorra. En estas páginas hacemos un recorrido por las cinco salas que componen el Museo, indicando la distribución de las piezas dentro del discurso expositivo, cómo se integran en la temática de cada una de los espacios y su relevancia dentro de la romanización de La Rioja. El Museo de la Romanización se inaugura en 2009, con el fin de rememorar la importancia de una ciudad bimilenaria como Calagurris Ivlia Nassica dentro de la Hispania romana, que obtuvo el rango de municipium civium romanorum con Augusto. Dicho centro museístico está dedicado a la exposición, conservación, investigación y difusión de la huella del mundo romano en La Rioja y se une a la red de espacios expositivos distribuidos por la Comunidad Autónoma de La Rioja.
Town-forming role of industry in vladikavkaz during the years of soviet authority
Authors: Sugarov David A.
Published: April 2024

The role of industry in the urban development of cities is increasingly attracting close attention against the backdrop of the variability of the modern world. Tracing this thematic chronology using the example of Vladikavkaz is relevant and applicable for cities of post-industrial Russia. The dynamics of spatial development of industry in the urban structure is a necessary vector for identifying the prospects for city development. This study covers the entire 235-year historical period of urban planning and architectural development of Vladikavkaz: the first part examines the initial period of 1784–1917, the second – the period of Soviet rule 1917–1990, the third – the final period from 1990 until now. The article represents the second part of the topic explored by the author.
Robot-assisted surgery of renal cell carcinoma in comorbid and frail patients
Authors: Simonyan Artur M. , Mosoyan Mkrtich S. , Shanava Gocha Sh. , Gilev Evgeny S. , Vasilev Artem A. , Fedorov Dmitriy A.
Published: April 2024

BACKGROUND: Renal cell carcinoma is predominantly observed in elderly patients. Many of them have multiple comorbidities, which can limit the feasibility of surgical treatment. The search for an optimal approach of radical treatment for comorbid and frail patients remains a current challenge.
AIM: To evaluate the perioperative outcomes of robot-assisted partial nephrectomy and radical nephrectomy in comorbid and frail patients with renal cell carcinoma.
MATERIALS AND METHODS: At the Almazov National Medical Research Centre we retrospectively studied the results of 118 comorbid and frail patients who underwent robot-assisted surgeries for localized renal cell carcinoma from 2012 to 2022. Mean age of men was 65.7 ± 11.4 years, and women was 61.3 ± 13.1 years. Comorbidity was assessed using the Charlson Comorbidity Index (CCI). Frailty was determined using a modified Frailty index (mFI-11). Robot-assisted partial nephrectomy and radical nephrectomy were perfomed by single experienced robotic surgeon. Perioperative functional outcomes were assessed. Renal function was evaluated based on glomerular filtration rate (GFR) using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula before surgery and at 1.3, and 6 months after surgery.
RESULTS: Among 118 patients, 71 (60.2%) underwent robot-assisted partial nephrectomy, while 47 (39.8%) underwent radical nephrectomy. Postoperative complications occurred in 15 (12.7%) of patients for robot-assisted surgeries. There were no positive surgical margins. Mortality in the early postoperative period amounted to 1.7% and was associated with the development of acute cardiovascular failure.
CONCLUSIONS: Robot-assisted partial nephrectomy and radical nephrectomy for renal cell carcinoma in comorbid and “fragile” patients — the safest and optimal method of treatment, accompanied by minimal perioperative complications and mortality.
Features of detrusor function disorders in patients with dysuria in the long period after transurethral resection of the prostate
Authors: Simanov Ruslan N. , Amdiy Refat E. , Kuzmin Igor V.
Published: April 2024

BACKGROUND: Transurethral resection of the prostate (TURP) remains the “gold standard” for surgical treatment of patients with benign prostatic hyperplasia. At the same time, a significant number of patients continue to have urinary disorders after surgery. Dysuric disorders may be caused by detrusor dysfunction.
AIM: The aim of the study was to determine the frequency, nature and clinical manifestations of detrusor dysfunction in patients with benign prostatic hyperplasia after TURP in the long-term postoperative period.
MATERIALS AND METHODS: We examined 128 patients with benign prostatic hyperplasia aged from 56 to 87 years (mean 68.5 ± 7.1 years), who underwent TURP 12–36 months before inclusion in the study. All patients had urinary problems at the time of examination. All patients underwent a urological examination, which included a complex urodynamic study. The control group consisted of 48 patients with benign prostatic hyperplasia of comparable age, who did not have urinary disorders after TURP.
RESULTS: Urodynamic signs of detrusor dysfunction were identified in 97 (75.8%) of 128 patients examined. Most often, isolated detrusor overactivity was detected (52.6%), less often a combination of detrusor over- and hypoactivity (25.8%) and isolated detrusor hypoactivity (21.7%). In patients with identified detrusor dysfunction, even before TURP, more pronounced urinary disorders were noted, which were characteristic of a certain type of detrusor dysfunction and persisted after surgical treatment. In patients with detrusor dysfunction, compared with patients from the control group, at the preoperative stage, urgency urinary incontinence, frequent urgency to urinate, diabetes mellitus, and a small volume of the prostate gland with the absence of intravesical protrusion were significantly more often detected.
CONCLUSIONS: Detrusor dysfunction is an important cause of dysuria in patients with benign prostatic hyperplasia in the long-term period after TURP. It seems appropriate to conduct further research to clarify the indications for performing preoperative complex urodynamic study in patients with benign prostatic hyperplasia and lower urinary tract symptoms.
Integral role of metabolic profiling in patients with prostate cancer
Authors: Pavlov Valentin N. , Urmantsev Marat F. , Bakeev Marat R.
Published: April 2024

Prostate cancer is the most diagnosed malignant neoplasm among males worldwide. Over the past few years, there has been a need to find alternative methods for early diagnosis of prostate cancer. There is evidence that metabolic dysfunction is a characteristic feature of the carcinogenesis of prostate cancer, with various metabolites acting as biomarkers of tumor growth. Metabolomics is a young science that arose at the junction of molecular biology, biochemistry and genetics. The complete set of substrates and metabolic products is a metabolic profile, or metabolome. The metabolome of prostate cancer is formed by substances formed as a result of metabolic changes in response to the occurrence of a malignant process in the prostate. Unique data on metabolic changes have already been obtained, allowing us to rethink the carcinogenesis of prostate cancer. The study of the metabolome opens up new opportunities for early diagnosis, prognosis and treatment of prostate cancer.
Effect of cognitive stimulation therapy in combination with other intervention modalities on cognitive ability in elderly with cognitive impairment: a quasi-experimental study
Authors: Turana Yuda , Sani Tara Puspitarini , Prasetya Virginia Geraldine Hanny , Suswanti Ika , Konny Lisye , Halim Magdalena Surjaningsih , Handajani Yvonne Suzy
Published: April 2024

BackgroundCognitive stimulation therapy (CST) has been proven to be beneficial in improving cognition and quality of life in people with mild cognitive impairment (MCI) and mild dementia (MD). This study investigates the benefit of more frequent exclusively CST intervention compared to less-frequent CST-exercise combination on cognitive ability among elderly people with cognitive impairment.
MethodsA quasi-experimental controlled study involving 22 subjects aged = 60 years with cognitive impairment. They were divided into three groups: group A (6 months, weekly CST + exercise sessions, n=13), Group B (3 months, twice-weekly CST-only sessions, n=5), group C (3 months, no intervention, n=4) as control. The Modified Mini Mental State Examination Indonesian Version was used for evaluating the cognitive ability of the elderly subjects. Data were analyzed using one-way Anova and Kruskal-Wallis tests
ResultsAll participants completed the study, the majority being female with mean age of 70.43 ± 6.97 years and differences in education level distribution across the three groups. The scores before and after the intervention showed a significant difference in the registration and construction domains (p<0.005). However, there was a greater improvement of the mean difference in cognitive scores in groups A and B compared to the control group, although the difference was not statistically significant (p >0.05).
ConclusionA twice-weekly CST-only intervention and a once-a-week CST-exercise combination provide better cognitive improvement than no intervention (control). Therefore, elderly people with cognitive impairment should be encouraged to engage in physical activities, brain training, and group activities for promoting the brain’s ability.
Developing a conceptual framework for burnout intervention program in the workplace
Authors: Sundram Bala Murali , Kusumareswaran Suriya
Published: April 2024

This review proposes a comprehensive conceptual framework for developing and implementing burnout intervention programs in the workplace. In recent years, job burnout has become a new and vigorous research hotspot in the field of psychology and human resources management at home and abroad. Job burnout has a serious impact on personal health and performance but also harms the work efficiency, organizational effectiveness, and even social stability of employees. With the escalating concern over employee burnout and its consequent negative impacts on both individual health and organizational productivity, there is a pressing need for effective strategies to mitigate this issue. The framework draws on extensive literature review and theoretical model analysis, integrating key theories such as the Job Strain Model, Effort-Reward Imbalance Model, Conservation of Resources Theory, and the Job Demands-Resources Theory to explore the multifaceted nature of burnout. It identifies critical components of burnout, including symptoms such as emotional exhaustion, depersonalization, and reduced personal accomplishment, and contributing factors such as high job demands, inadequate job resources, and personal traits. Intervention strategies such as exercise have been identified as beneficial in addressing burnout. A systematic review of six studies highlights that aerobic exercise effectively lowers burnout and stress levels among employees. The framework also examines mediating factors such as personality traits and external factors, evaluating outcomes such as improved mental and physical health, enhanced job performance, and better workplace environment. Moreover, this review discusses the sustainability of interventions and emphasizes the importance of tailoring approaches to fit specific organizational contexts. The proposed framework provides a structured approach to understanding and addressing workplace burnout, highlighting the necessity for ongoing research and adaptation of intervention programs to meet evolving workplace dynamics.
Management of Separated Endodontic Instrument in Mandibular Second Molar with Bypass Technique
Authors: Aristiyanto Regia , Rovi Fineza
Published: April 2024

One of the most common mishaps in root canal treatment is a separated endodontic instrument. Bypass technique is an effective alternative besides file retrieval while clinical conditions have lack of access and visibility. Other than, this technique gives a more conservative outcome because it prevents more dentin removal. The aim of this case report was to describe management of separated endodontic instruments in the mandibular second molar with bypass technique during endodontic treatment. A 3,5 mm F1 ProTaper Hand Use file was separated in the mesiobuccal canal of the mandibular second molar. Radiograph examination was taken to make sure the level of fragment. Bypass was performed with #10 until #25 K-File to pass the separated instrument through the gap between it and the root canal wall. Obturation has been done with gutta percha and resin-based sealer using cold lateral condensation technique. Direct restoration was chosen as final restoration after 6 days follow up. Bypass technique can be performed as management of separated instrument considering the risks involved fragment extrusion to apical region, secondary separated instrument, and conservative aspect.
Management of Abnormal Frenulum and Gingival Enlargement in One Visit
Authors: Hartanti Hartanti , Kimera Assanian Dyah
Published: April 2024

Gingival enlargement or excessive gingival growth, is a common occurrence in  gingival disease, characterized by an increase in the size of the gingiva. Inflammatory gingival enlargement or inflammatory gingival enlargement is an inflammatory response to local irritation related to the gingiva. The most frequently performed treatment for gingival enlargement is gingivectomy. A high frenulum makes it easier for the gingival margin to be pulled so that plaque is easily trapped in the sulcus which results in periodontal disease and can be corrected with a frenectomy procedure. A 22-year-old female patient came to RSGM UMY complaining that her upper front gums had become enlarged so she was lacking self-confidence. Intraoral objective examination revealed enlarged gingiva on the interdental papillae of the maxillary anterior teeth (12, 13, and 21) which were rounded, light red in color with the surrounding gingiva, and had a smooth surface. There is a high frenulum with a height of 8 mm. A blanching test was carried out to examine the frenulum and the results were positive (+).Gingivectomy can be performed with a conventional scalpel, electrosurgery, chemosurgery, and laser. Conventional gingivectomy surgery performed with a small scalpel has been considered the most common method due to its ease of use, accuracy, and minimal tissue damage. Frenectomy can also be performed using various methods, such as using a scalpel, electrosurgery, or laser. Gingivectomy and frenectomy surgical procedures are effective in managing enlarged gingiva with a high frenulum
Comparison of The Effectiveness of Fones and Modified Bass Teeth Brushing Methods on Reducing Plaque Index in Autism Spectrum Disorders Children Aged 6-12 Years
Authors: Shafira Nabilah , Prasasti Annisa Widya , Octavia Alfini
Published: April 2024

Children with special needs, such as Autism Spectrum Disorders (ASD), are at a higher risk of developing caries. Brushing teeth is the most effective preventive measure to avoid the risk of developing dental and oral diseases. The Fones teeth brushing method has been proven to reduce dental plaque in ASD patients due to its simplicity. The modified Bass method is also reported to be effective in removing interdental plaque. This study is to investigate whether there is a difference in the effectiveness of teeth brushing techniques, specifically the Fones method and the modified Bass method, in reducing the plaque index in children with ASD.   A quasi-experimental study with a pre-test and post-test design was conducted, with 24 ASD participants aged between 6-12 years. The Loe and Silness Plaque Index was used to measure the plaque index. Data analysis was conducted by comparing the two methods using a Paired t-test and a one-way ANOVA test. Indicate that there is a significant difference between the two treatments with a significance value of 0.039 (P<0.05). The average plaque index from the Fones method was found to be 0.444 greater than the modified Bass method. In conclusion: There is a difference in effectiveness between the Fones teeth brushing method and the modified Bass teeth brushing method in reducing the plaque index in children with ASD aged 6-12 years.
Ramadan Fasting and Saliva Characteristics
Authors: Arinawati Dian Yosi
Published: April 2024

Ramadan fasting is the absence of swallowing or limiting food and drink for a certain period, usually having a duration of between 28 and 30 days with an average period of 12 hours. One of the first biological fluids to experience changes in eating habits and changes to the environment or physics in the oral cavity during fasting is saliva. Changes that can occur are a decrease in saliva production which will result in a decrease in the function and components of saliva in the oral cavity. The purpose of writing this review is to determine the effect of fasting on saliva characteristics. This Literature Review was prepared using various sources, most of which are within the last 5-10 years. The literature search used as a data source used Google Scholar and PubMed. The keywords used are "saliva", "fasting", "ramadan fasting", "salivary flow", "saliva composition", "biochemistry of saliva". Changes in saliva characteristics during fasting include a decrease in saliva flow rate, complaints of dry mouth or xerostomia as well as changes in saliva composition, namely a decrease in inorganic components of saliva such as phosphate and calcium. During Ramadan fasting there is a risk of decreasing flow rate which in turn can affect the condition of the oral cavity.
Periodontal Abscess Occurrence Post Wire Splint Therapy on Mobile Teeth
Authors: Andriani Ika , Gunawan Azka Rajarizqi , Desky Alifia Lubhi
Published: April 2024

Tooth mobility is one of the cases of periodontal disease caused by the destruction of the bone that supports the teeth. Stabilization of loose teeth using splinting wire can be one of the treatment options. The use of splinting wire may increase plaque accumulation and is sometimes difficult to clean. Plaque accumulation will cause bacterial invasion into the surrounding tissues of the periodontal pockets which will eventually develop into an inflammatory process. As time goes by, connective tissue destruction and pus formation will occur which eventually leads to a periodontal abscess. Periodontal abscess is a localized accumulation of pus in the gingival wall of a periodontal socket with periodontal tissue destruction. The purpose of this case report is to report the incidence of periodontal abscess after wire splinting application in a case of tooth unsteadiness. A 76-year-old female patient came to RSGM with complaints of feeling uncomfortable because some of her teeth were loose. The complaint has been felt approximately 1 year ago. The complaint was accompanied by pain when used to eat and toothbrushing. Objective examination showed reddish gingiva, rounded interdentals, soft consistency, and unstippling texture on the labial and lingual side of teeth 33, 32, 31, 41, 42 and 43 with BOP (+) at all points. The patient's Oral Hygiene Index (OHI) was 2.16 and PI was 18.67%. Probing depth average was 3 mm, recession was 3 mm, and tooth decay was grade 2. Supportive examination showed horizontal bone destruction in the anterior region of the mandible. The first visit was carried out wire splinting on the lingual part of the loose tooth, at the time of control there was a periodontal abscess on the labial side so the splinting was moved to the labial side. The increase in socket depth and the appearance of periodontal abscesses are caused by plaque accumulation which eventually makes bacteria invade the periodontal tissue. Periodontal therapy really needs to pay attention to the patient's OHI, therefore plaque control and removal of bacterial deposits must be carried out by scaling and root planning regularly and carrying out other periodontal therapies such as curettage if tissue destruction is severe enough
Treatment of Tooth Relapse Using Removable Orthodontics Appliances
Authors: Utari Tita Ratya , Avisa Desi Lia
Published: April 2024

At present, fixed orthodontic appliances treatment is extensively utilized with excellent outcome. Nevertheless, complications frequently arise following the conclusion of orthodontic treatment, predominanly relapse. Relapse refers to repositioning teeth to their pre-treatment state; its progression is stochastic, thereby rendering relapse possible for each individual. Patients who fail to wear retainers consistently will relapse of the affected teeth after orthodontic treatment. Therefore, this case report details the successful treatment of tooth relapse with a removable orthodontic appliance. A 22-year-old female patient complained of irregular alignment of her lower front teeth. The patient received two years of treatment with fixed orthodontics; however, she ceased using retainers regularly after treatment concluded. An objective examination indicated that the teeth in the upper jaw teeth remain in a well-aligned position; however, the lower jaw exhibited that tooth 32 was mesiolabiotorsiversion, tooth 33 was distolinguotorsiversion, tooth 41 was labioversion, tooth 42 was mesiolinguotorsiversion, with an overjet of 3 mm and an overbite of 2 mm. Afterward, the malposition of the lower jaw teeth was corrected with an expansion plate for a removable orthodontic appliance. Following 20 follow-up treatments over five months, the malposition of the lower jaw teeth has been corrected. As a result, it can be deduced that removable orthodontic appliances continue to be efficacious in rectifying mild malposition caused by dental relapse, thereby obviating patients' need to reapply costly fixed orthodontic appliances.
Pyogenic Granuloma of the Gingiva
Authors: Mahanani Erlina Sih , Rahmanida Alfaiatu Nurul
Published: April 2024

Pyogenic granuloma is a benign vascular lesion that usually occurs in response to various stimuli caused by chronic irritation, trauma and hormonal factors. These lesions generally occur on the gingiva but can also occur on the lips, tongue and buccal mucosa. A 22 year old female patient came with complaints of a lump on the gingiva between teeth 35 and 36 and felt uncomfortable. I have had complaints since 7 months ago after a filling was made on the left back molar tooth, then 1 day later a lump appeared. Complaints are not accompanied by pain. The treatment plan in this case is to carry out information education communication, scaling, gingivectomy and a histopathological examination to confirm the diagnosis and carry out control and evaluation. Pyogenic granuloma is a benign, non-neoplastic lesion. The clinical picture of this lesion is generally a mass with a soft consistency, painless, and dark red to reddish purple in colour which usually appears as a solitary lesion with a diameter of 5-10 mm and is very fragile, so it bleeds easily due to minor trauma. Management of this lesion can be done with a surgical procedure to completely remove the lesion and then carry out an anatomical histopathological examination to confirm the diagnosis of this lesion. This lesion has no signs of malignancy
Tele-assessment of Berg balance scale, timed-up, go and box and block test in patients with chronic stroke: establishing agreement with the face-to-face assessment
Authors: Panagiotopoulou Efthalia , Mavronasou Aspasia , Spanos Savvas , Kortianou Eleni A.
Published: April 2024

Background: The COVID-19 pandemic has triggered rapid adaptive actions in favor of remote interventions and clinical assessment methods. The reliability of functional tests used in remote assessment is limited in patients with chronic stroke. The aim of the study was to assess the inter-reliability of the Berg balance scale, the timed-up and go test, and the box and block test via remote assessment, in patients with chronic stroke.
Methods: Fifteen patients (8 men and 7 women) underwent a home-based teleassessment using a software platform and a center-based face-to-face assessment, on two consecutive days. The assessment order was randomized and conducted by an independent examiner. All participants were instructed regarding the use of the software platform, home equipment preparation, and safety issues
Results: Participants aged 50-70 years (mean 59.6±7.34) with an average of 4.8±2.5 years after stroke and a moderate degree of motor dependence (Barthel scale: mean 83±8.61 units) completed all tests in both assessment procedures without experiencing adverse events. The inter-reliability was moderate for the total BBS score: ICC=0.869 (95% CI: 0.616 to 0.955), excellent for the total time of the TUG: ICC=0.968 (95% CI: 0.907 to 0.989) as well as for the upper right and left arm scores of the BBT: ICC=0.974 (95% CI: 0.922 to 0.991) and ICC=0.966 (95% CI: 0.897 to 0.988), respectively.
Conclusions: Tele-assessment for BBS, TUG, and BBT appears moderate to excellent inter-reliability in functionally independent patients with chronic stroke.
Tracheobronchopathia osteochondroplastica: Case report of a rare cause for a common symptom
Authors: Adiody Supriya , Krishnakumar Krishnanand , Raghunath Sruthi , Raman Aravind Thayyil
Published: April 2024

Tracheobronchopathia osteochondroplastica is a rare disease which is characterised by the presence of osseous and/or cartilaginous submucosal nodules projecting into the anterior and lateral walls of the airways. We present the case of a 56-year-old male presenting with chronic cough, dyspnoea and haemoptysis. An initial diagnosis of tuberculosis was kept in mind considering the endemicity of the disease. A fibre optic bronchoscopy, however helped in clinching the diagnosis. As there are no guidelines for the treatment, conservative treatment with inhaled steroids,bronchodilators, antibiotics, and avoidance of the airwayirritants, is sufficient for the patient. On follow up after 2 months patient is doing fine with symptomatic improvement.
Health Innovation & Technology in Latin America & the Caribbean: Market Landscape and Compendium of Companies
Authors:   Holon IQ,   IDB Lab
Published: April 2024

Compendium of health innovation startups in the region, complementing the report of a comprehensive analysis of health startups in Latin America and the Caribbean (LAC), delving into the challenges, trends, and investments in the region.
Computed tomographic investigation of a hatchling skull reveals ontogenetic changes in the dentition and occlusal surface morphology of Hadrosauridae (Dinosauria: Ornithischia)
Authors: Warnock-Juteau Trystan , Ryan Michael , Patterson Tim , Mallon Jordan
Published: April 2024

CMN 8917 is a small, partial skull of a duck-billed dinosaur from the upper Campanian DinosaurPark Formation in what is now Dinosaur Provincial Park, Alberta. It represents one of the few nestling-sized juvenile hadrosaurines known to date. Support for this phylogenetic placement includes a narial vestibule not enclosed within the premaxillary dorsal and lateral processes, the presence of an anterodorsal maxillary process, and a maxillary dorsal process that is longer anteroposteriorly than dorsoventrally. The skull also possesses tooth traits traditionally associated with lambeosaurines, such as secondary ridges on some maxillary and dentary tooth crowns, and denticulation on some maxillary tooth crowns. The occurrence of these features in a juvenile hadrosaurine suggests that they were modified during ontogeny, calling into question their taxonomic utility for identifying juvenile specimens. The dentary teeth of CMN 8917 are similar to those of many adult hadrosaurids in that they possess a concave occlusal surface with steeper lingual and shallower buccal wear zones. This differs from the occlusal surface morphology present in some other juvenile hadrosaurids, which suggests interspecific differences in dental battery development—possibly reflective of dietary differences—occurred during early ontogeny in some taxa.
Analysis of Foreign Direct Investment in the Basque Economy and its Companies and Assessment of its Effect on Competitiveness
Authors: Kamp Bart ,   Universidad de Deusto, Carrillo Francisco ,   Universidad de Deusto, Pescarin Francesco ,   Universidad de Deusto
Published: April 2024

Foreign direct investment (FDI), both outbound and inbound, is relevant to an economy because it can contribute to its economic growth, job creation, technology transfer, and integration into cross-border value chains, as well as international economic spaces. Against this backdrop, the report "Analysis of foreign direct investment in the Basque Country and its companies" investigates the state of inbound and outbound FDI in the Basque Country. It does so through aggregated data for the period 2014-2021 and the analysis of a series of cases of Basque companies acquired by foreign entities. It concludes with a series of recommendations for policymakers on issues affecting inbound FDI.
Análisis de la inversión extranjera directa en la economía vasca y sus empresas y valoración de su efecto sobre la competitividad
Authors: Kamp Bart ,   Universidad de Deusto, Carrillo Francisco ,   Universidad de Deusto, Pescarin Francesco
Published: April 2024

La inversión extranjera directa (IED), tanto saliente como entrante, es relevante para una economía porque puede contribuir a su crecimiento económico, a la creación de empleo, a la transferencia de tecnología y a su integración en cadenas de valor transfronterizas, así como en espacios económicos internacionales. Ante este telón de fondo, el informe “Análisis de la inversión extranjera directa en la economía vasca y sus empresas” indaga sobre el estado de la IED entrante y saliente en el País Vasco. Lo hace a través de datos agregados respecto al periodo 2014-2021 y el análisis de una serie de casos de empresas vascas que fueron adquiridos por entidades extranjeras. Concluye con una serie de recomendaciones para policy makers acerca de asuntos que inciden en la IED entrante.
PRISÃO DO CASAMENTO: LEITURA COMPARADA ENTRE A CLITEMNESTRA, DE ÉSQUILO, E A EMMA BOVARY, DE FLAUBERT
Authors: Irigaray Tiago
Published: April 2024

Resumo: a despeito dos mais de 2000 anos transcorridos entre as duas narrativas, Clitemnestra e Emma Bovary experienciam muitas dores e agruras em comum, a maior parte delas por causa da instituição do casamento e sua configuração patriarcal. Os paralelos são marcantes e atravessam não apenas o tempo, mas  também a barreira dos gêneros literários (o gênero trágico da Grécia Antiga e o Realismo do século XIX), embora o Realismo, esse gênero sério burguês, carregue uma herança trágica que o faça apropriado para questionar instituições sociais, como a tragédia também questionava, embora de forma difusa, intuitiva e errática porque a tragédia grega aconteceu em moldes pré-Iluministas e possui uma estrutura conflituosa única na literatura antiga. O insólito paralelo entre Clitemnestra e Bovary revela muito sobre o que permaneceu arraigado na instituição do casamento e também na literatura.
Gender Differences in Knowledge, Experience, and Preference of Sustainable Investments
Authors: Grumann Laura , Madaleno Mara , Vieira Elisabete
Published: April 2024

Recent and ongoing regulatory efforts of the European Commission have made sustainable investments a relevant topic for the broader public. Likewise, the economy itself and the financial markets within the European Union are in transition to support the overall goal of climate neutrality by 2050. Scientific research mostly focused on professional or institutional investors, hardly on retail investors. This study aimed to investigate whether there are significant gender differences in prospective retail investors’ knowledge, experience, and preference for sustainable investment (SI). The research was based on data from a survey conducted by the Portuguese Securities Market Commission at the end of 2020, containing a general section on investments in securities as well as a section dedicated to sustainable investments. To test the hypothesis of equalness, chi-square tests were applied. In the second step, multinomial logit regression testing and marginal effects were computed to identify determinants of sustainable investment knowledge and experience. The results proved that there are gender differences in the knowledge of sustainable investing. Well-known gender differences in general investment knowledge and behavior were confirmed.
El canto del alma de la persona difunta: Creencias de los lacandones del sur acerca del cuerpo, del alma y de la muerte
Authors: Boremanse Didier
Published: April 2024

Después de un compendio histórico relativo a los lacandones actuales, se expone su concepción de los vestigios arqueológicos que abundan en su territorio. A continuación se presentan datos con respecto a los dioses de los lacandones del sur y de sus ideas acerca del alma y de la muerte, imprescindibles para entender los versos que canta el alma. El canto relata las diferentes fases por las que pasa el alma durante el proceso de fallecimiento en su transición entre el mundo humano y el mundo de los dioses. Siguen una descripción de las exequias lacandonas y una explicación del vocablo utilizado en el canto para designar el cuerpo de la persona. Al final se compara este canto con el “canto a un muerto” de los lacandones del norte.
KEY SUCCESS FACTORS OF SCHOOL LEADERSHIPS IN IMPLEMENTING PROFESSIONAL LEARNING COMMUNITY: A SYSTEMATIC LITERATURE REVIEW
Authors: Siwy Vanessa Elizabeth , Meilani Yohana Cahya Palupi
Published: April 2024

The study systematically reviews the literature to understand the key success factors for school leadership in fostering PLCs and the most effective leadership style for this endeavor. Through a detailed analysis, it identifies key success factors such as visionary leadership, shared values, effective communication, collaborative decision-making, and strategic problem-solving. The study also emphasized the transformative, facilitative, distributed, democratic, and situational leadership styles conducive to PLC success.. These elements are essential for creating a collaborative learning environment that promotes professional growth, innovation, and improved student outcomes. The study acknowledges limitations including the scope of literature and challenges in directly correlating leadership styles with PLC success. Future research directions include exploring the long-term impact of leadership on PLCs, cross-contextual comparisons, empirical validations of theoretical frameworks, and the role of digital technologies in PLC enhancement.

 
Disputable issues of challenging the debtor’s transactions under paragraph 2 of Article 61.2 of the Bankruptcy Law
Authors: Sasykin Konstantin Yu.
Published: April 2024

The issues related to the debtor’s transactions on the eve of bankruptcy and contestation such transactions on the basis of paragraph 2 of Article 61.2 of Federal Law No. 127-FZ dated October 26, 2002 “On Insolvency (Bankruptcy)” as committed with the purpose of causing harm are considered. Attention is paid to the analysis of individual judicial and arbitration practice and the courts’ assessment problems of individual circumstances. The purpose of the study is to analyze the grounds and problematic practice of contesting transactions under paragraph 2 of Article 61.2 of the Federal Law of October 26, 2002. No. 127-FZ, highlighting controversial issues – criteria that allow the courts to refuse to satisfy the requirements for declaring transactions invalid on this basis. Analytical, systematic, technical and legal methods are used in the research. Based on the results of the work carried out, attention is drawn to the erroneous practice of some courts in assessing the awareness of the debtor’s counterparty about the purpose of causing harm to the disputed transaction when they are committed in relation to real estate and other large transactions. The necessity of developing the integrity institute, avoiding the courts from applying formal criteria of persons’ interest is noted, the importance of assessing all the circumstances of the counter-agent’s behavior and the need to lower the standards of proving his dishonesty in certain cases is noted.
Actos de habla interrogativos en pima bajo
Authors: Estrada-Fernández Zarina
Published: April 2024

Este trabajo analiza los distintos tipos de actos de habla interrogativos que se han observado en pima bajo, lengua de la rama tepimana de la familia yuto-azteca hablada en la región noroeste de México. El análisis considera los distintos tipos de construcciones interrogativas, sus particularidades y diferencias tomando como referencia lo propuesto por autores que han analizado este dominio funcional desde una perspectiva tipológica. El estudio considera tres tipos de construcciones interrogativas: (i) las interrogativas de argumento o contenido, (ii) las interrogativas polares y (iii) las preguntas de coletilla. El artículo describe la lista completa de los pronombres interrogativos en pima bajo, sus cambios fonológicos, la ocurrencia de interrogativos complejos, algunas observaciones sobre la prosodia en algunas construcciones interrogativas y también proporciona una visión comparativa de los elementos interrogativos de esta lengua con los de otras lenguas yuto-aztecas para discutir el posible origen diacrónico de estos elementos.
Influence of sitting time on pulmonary function in computerusing office workers
Authors: Upmanyu Aditi , Kumar Amit , Kalia Varun
Published: April 2024

[Purpose] We aimed to identify the changes in pulmonary function after prolonged sitting. Pulmonary function tests (PFTs) allow physicians to assess the respiratory capability of patients under numerous clinical circumstances and when there are risk factors for lung sickness, occupational exposure, and pulmonary toxicity. PFTs are routinely performed in the standing or high sitting position because of the devices and patient comfort.[Methods] A total of 180 asymptomatic office workers were recruited as eligibility criteria and divided into three groups according to their daily sitting duration (group 1:2–4 h, group 2:4–6 h, and group 3: > 6 h). PFTs were performed twice consecutively to determine the mean of the readings. A Helios 401 spirometer was used to quantify lung function. The parameters were “forced expiratory volume in 1 s (FEV1)”, “forced vital capacity (FVC)”, “peak expiratory flow rate (PEFR)”, and the “ratio of FEV1 to FVC (FEV1/FVC)”.[Results] Our results suggest that noteworthy changes were present in the lung function of all the participants. For individuals with > 6 h of sitting; FVC, FEV1, and PEFR were higher compared to those of the participants with 2–4 h and 4–6 h of sitting. The FEV1/FVC ratio was also reduced in individuals with prolonged hours of sitting.[Conclusion] Body position impacts the result of PFTs; however, that as it may, the ideal position and extent of advantage changed between the review populaces. These results suggested that noteworthy changes occur in the lung function of healthy individuals exposed to sitting time.
Chemical composition and trajectories of atmospheric particles at the Machu Picchu Peruvian Antarctic scientific station (62.09º S, 58.47º W)
Authors: Álvarez-Tolentino Daniel , Suárez-Salas Luis , Pomalaya-Valdez José , Barja Boris
Published: April 2024

Antarctica is a remote and relatively pristine region, but the regional transport of aerosols may be a source of pollution, especially in the Antarctic Peninsula. Few studies have characterized atmospheric aerosols and evaluated the contribution of their emission sources. The Peruvian Antarctic research station Machu Pichu (ECAMP, by its Spanish acronym) is located on King George Island in the Antarctic Peninsula. During February 2020, atmospheric particulate mass (PM10 and PM2.5) was sampled and analyzed to characterize its elemental composition and was supplemented by measurements of equivalent black carbon and aerosol size distributions. Chemical elements were analyzed by inductively coupled plasma mass spectrometry (ICP-MS), multivariate techniques, and enrichment factors. The most abundant elements in PM10 and PM2.5 were Na, Fe, Mg, and Si, with the most important local sources being marine (Na, Mg, Mn, Ca) and crustal (Fe, Al, P). Sources of weathering (Ba and Si) from glacial thawing and sources of combustion linked to the use of oil (V) and emission of black carbon were recorded. Air mass back-trajectory analysis using the HYSPLIT model helped identify external sources of particulate matter in the air masses reaching the ECAMP site. Overall, this study supports the growing evidence of the anthropogenic impact of distant and local sources on the white continent.