bluuebunny/crossref_metadata_2025 huggingface dataset:
Survey of the Influence of Routing Protocols to Network Performance Enhancement
Authors:   1Department of Mathematics 2Department of Computer Science Faculty of Science,  Niger Delta University Wilberforce Island, Nigeria., Consul Juliana  .I. , Bunakiye Japheth .R.
Published: November 2023

Routing protocols play a crucial role in the operation of computer networks by determining the optimal paths for data transmission. The selection of an appropriate routing protocol can significantly impact network performance, including factors such as latency, throughput, reliability, and scalability. This survey aims to provide a comprehensive analysis of the influence of various routing protocols on network performance enhancement. The survey begins by presenting an overview of common routing protocols with their key characteristics. Subsequently, it explores the impact of these protocols on network performance metrics, focusing on their ability to adapt to changing network conditions, mitigate congestion, and ensure efficient resource utilization. Through a systematic review of literature, empirical studies, and real-world implementations, this survey aims to provide network administrators, researchers, and practitioners with valuable insights into selecting and optimizing routing protocols for specific network environments. Additionally, it identifies areas for further research and development to continue advancing the field of routing protocols and network performance enhancement. Keywords: Optimizing Routing Protocols, Performance Metrics, Reliability and Scalability, Resource Utilization, Wireless Local Area Networks, Accurate Routing Tables Juliana I. Consul & Bunakiye R. Japheth (2023): Survey of the Influence of Routing Protocols to Network Performance Enhancement. Journal of Advances in Mathematical & Computational Science. Vol. 11, No. 4. Pp 13-28 Available online at www.isteams.net/mathematics-computationaljournal. dx.doi.org/10.22624/AIMS/MATHS/V11N4P2
“On the streets of diversity”. Urban space as a birthplace of free expression and artistic creation: the case of Nikolas Asimos in the Exarchia area of Athens
Authors: Kyriazakos Emmanuel , Katsadoros George
Published: November 2023

Artistic creation depends to a great extent on man-made environment and
relationships that connect the artist with it, as well as on his/her
experiences and perceptions. The singer and actor Nikolas Asimos still
remains, 35 years after his death, an emblematic figure of Exarchia, a
central area of Athens, frequently associated with intense
anti-authoritarian activity. In this research, we focus on the
social-cultural conditions that prevailed in the area, between 1976-1988, a
period when Nikolas Asimos lived there and created the majority of his work.
Through content analysis of the opinions of people who knew him or dealt
with him on a professional basis, we argue that the urban space of Exarchia
greatly contributed to the creative mood of the specific artist, providing
him with the appropriate conditions for free expression of his work and
ideas.
Giant left lobe hemangioma of the liver misdiagnosed for splenomegaly
Authors: Toskovic Borislav , Milosavljevic Vladimir , Buzejic Matija , Stanisavljevic Natasa , Zdravkovic Darko
Published: November 2023

Introduction. Most patients with liver hemangiomas are unrecognized, when symptoms occur it is usually due to the size of the hemangioma. Hemangioma of the liver are benign tumors which affects women more often. Surgical indications for liver resection remain unclear. Case outline. We present a patient with a giant hemangioma of the left liver lobe that was misdiagnosed in a primary care unit. The patient underwent resection of the left liver lobe and fully recovered after several days. Conclusion. Symptoms, size, and risk of rupture should be considered when decision for surgery is made. Linear stapler can be useful especially when left and middle hepatic vein have common trunk.
Land health monitoring framework: Towards a tool for assessing functional and habitat diversity in agroecosystems
Authors: Dussán López P.
Published: November 2023

Biodiversity is context-specific, and there are no one-size-fits-all indicators or monitoring methodologies. Nevertheless, the lack of common metrics to measure and monitor biodiversity at different levels in agriculture poses a barrier to mobilizing actors, setting ambitious targets and assessing policy impact. This publication seeks to overcome that barrier through a flexible framework that uses existing tools to assess functional and habitat diversity by measuring diversity at various scales, including belowground, aboveground, habitat-level and national impact (impact on land-use change or downstream pollution).
Quantifying and Characterizing the Presence of Insulin Overbasalization in a Family Medicine Practice
Authors: Stewart-Lynch Autumn , Meyers Rebekah , Sidig Dina , McConville Sea-oh , Heiple Lindsay
Published: November 2023

The American Diabetes Association advises clinicians of the potential for insulin overbasalization in the management of type 2 diabetes. Described as the titration of basal insulin beyond an appropriate dose, overbasalization increases risks for adverse effects such as hypoglycemia and weight gain without achieving the glycemic targets needed to optimally manage the disease. There is a need to determine the prevalence of and clinical factors that can lead to overbasalization. This study aimed to assess the prevalence of and characterize the patient variables associated with overbasalization in a family medicine practice.
Critique and Improvement of the Regulatory Framework on the Calculation of Structures for Seismic Impacts
Authors:   Research Institute of Building Constructions (TSNIISK) named after V.A. Koucherenko, JSC Research Center of Construction, Vedyakov I.I. , Vostrov V.K. ,   Research Institute of Building Constructions (TSNIISK) named after V.A. Koucherenko, JSC Research Center of Construction
Published: November 2023

In the work of Kurbatsky E.N., Mondrus V.L. «Dynamic Coefficients or Response Spectra of Structures to Earthquake?» with the reference to the norms of the technically developed countries, as well as to the monographs of the famous foreign scientists, an erroneous statement was put forward that during earthquakes the ground parts of structures are not subject to the influence of any external forces, and that the internal stresses and deformations in the elements of structures are created exclusively due to dynamic reactions to movement of their bases. It does not state that the cancellation of the action of gravity is associated with the inadequacy (incompleteness) of the mathematical models of the interaction of foundations and structures, but argues that if the force of gravity is clearly absent in the vibration equations, then it does not act on the structure. This incompleteness of ideas is present in the equation of horizontal vibrations in translated and domestic works, but in them, unlike the reviewed works, it is not stated that during earthquakes the ground parts of structures are not subject to the influence of any external forces. The main reasons for the incompleteness (inadequacy) of the mathematical models of foundations and structures and their interaction was identified, which are that the center of gravity of the structure is located at the level of the base, and also that when deriving the equations for horizontal and vertical vibrations of the structure, the incomplete (selective) deformability of the base is used. But the selective deformability of the base when deriving the classical equations of horizontal and vertical vibrations does not allow rocking vibrations of the structure to occur under only horizontal or only vertical seismic influences, and this is a significant drawback of the mathematical modeling of the vibration processes of structures on a completely deformable base. To eliminate this shortcoming, the work presents differential equations for translational and rocking plane-parallel vibrations of a rigid structure on a completely yielding foundation, including the effects of gravity. From them, in particular, it follows that as the height of the center of gravity tends to zero, these equations turn into classical linear equations of oscillations in the horizontal and vertical directions.
Analytical Methodology for Substantiating the Optimal Frequency of Scheduled Inspections of the Fire-fighting Condition of Industrial and Warehouse Buildings
Authors:   FGBU VNIIPO EMERCOM of Russia, Matyushin A.V. , Kondashov A.A. ,   FGBU VNIIPO EMERCOM of Russia, Matyushin Yu.A. ,   FGBU VNIIPO EMERCOM of Russia, Sibirko V.I. ,   FGBU VNIIPO EMERCOM of Russia
Published: November 2023

The purpose of the work is to analyze the statistical information about fires to establish the dependence of the number of fires in the industrial and warehouse buildings on the frequency of scheduled inspections and, on this basis, to develop a methodology for justifying the optimal frequency of scheduled inspections of their fire safety status by the federal state fire supervision authorities of the Ministry of Emergency Situations of Russia. For the first time, the mathematical models were obtained to determine the number of fires at industrial and warehouse protection facilities depending on the time elapsed since the last inspection, as well as to determine the number of fires at these protection facilities depending on the frequency of their scheduled inspections. The scientific novelty of the work lies in the fact that for the first time, on a scientific basis, an original method for substantiating the optimal frequency of scheduled fire safety inspections of industrial and warehouse protection facilities was developed and tested. The data obtained allows to substantiate on a scientific basis: the optimal frequency of scheduled inspections of the fire safety condition of industrial and warehouse buildings; the belonging of these objects of protection to the appropriate risk category, depending on the required frequency of their scheduled inspection; the required number of personnel of the federal state fire supervision bodies of the Ministry of Emergency Situations of Russia for timely and high-quality inspection of the supervised protection objects. The results of the work also make it possible to justify the need to amend the Regulations on the Federal State Fire Supervision, approved by Decree of the Government of the Russian Federation dated April 12, 2012, № 290, in terms of establishing an alternative method to the Federal Law dated July 31, 2020, № 248-FZ for justifying the frequency of scheduled control (supervision) activities in relation to the objects of control and their assignment to the appropriate risk category.
Photoelastic Stress Induced by Maxillary Denture on the Mandibular Denture and Overdentures Lined with Silicone-based Material
Authors: Campana Júlia Trevizam , De Arruda Nóbilo Mauro Antônio , Consani Rafael Leonardo Xediek
Published: November 2023

Objectives: This study evaluated the stress induced by maxillary denture over mandibular denture and overdentures lined with silicone-based material.
Materials and Methods: Three maxillary dentures, a mandibular denture, an overdenture supported by a single implant, and other supported by two implants were made for the following groups: MCD—Mandibular complete denture lined with silicone-based material, OSI—Overdenture lined with silicone-based material supported by single implant, and OTI— Overdenture lined with silicone-based material supported by two implants. The mandibular photoelastic model was axially loaded by the maxillary denture with intensities of 10, 20, or 30 kgf. Photoelastic analysis took place with the maxillary denture in maximum intercuspation with the mandibular prostheses.
Results: Photoelastic analysis showed that the 10 kgf load promoted in the mandibular denture greater stress along the photoelastic model mainly in the anterior region. Stress occurred around the single implant with higher intensity at the apex. Stress occurred between the two implants and no stress was shown along the implants and apices. For 20 kgf, stress occurred in the anterior region of the mandible denture; Higher stress is shown around the single implant and apex and smaller at the mandible left side. Stress occurred between the two implants, and few stress at the apex of the left implant. For 30 kgf, stress occurred in the anterior region of the mandible with more intensity on the left side. Stress is shown around and at the implant apex and both mandible frontal sides. Stress is shown between the two implants and little stress at the apex of the left implant.
Conclusions: The lined overdentures supported by single or two implants exhibited stress concentration in the implant region compared to lined mandibular denture showing stress along the mandible body. The stress in the overdentures occurred mainly around the single implant or between the two implants. The increase in load intensity had little influence on the increase in stress for the prostheses with lined bases.
Clinical Relevance: Intercuspation in the overdenture must have the same importance given to the vertical relationship to relieve the chewing effort in overdenture lined with silicone-based material.
Hormonal profile features in patients with infertility against the background of uterine leiomyoma and chronic endometritis
Authors: Khmil S.V. , Petryshyn N.Ya.
Published: November 2023

The аim of research is to study the hormonal profile peculiarities of women with infertility against the background of uterine leiomyoma and chronic endometritis with unsuccessful IVF attempts in the anamnesis.Material and Methods. A retrospective analysis of the outpatient medical cards of 130 patients with infertility was carried out. Patients were divided into three clinical groups. The first group of the study consisted of 47 women with unsuccessful IVF attempts and uterine leiomyoma, the second one included 53 women with infertility against the background of uterine leiomyoma and chronic endometritis (patients in this group also had failed IVF attempts in the anamnesis). The third (control) group consisted of 30 female infertility patients due to the male factor. The concentration levels of the main gonadotropic and sex hormones in blood serum were studied and compared on different days of the menstrual cycle.Results. Certain changes in the hormonal profile, including the basal concentration of hormones of the reproductive system and their levels on different days of the menstrual cycle, were revealed among the women of the studied groups compared to the control group.Conclusions. The hormonal profile features in patients with infertility against the background of uterine leiomyoma and chronic endometritis are primarily related to the presence of one or another concomitant gynecological pathology, or their combined course. This definitely probably has an impact on the further results of infertility treatment with ART.
Wound healing and soft tissue regeneration. Literature review
Authors: Volovar O.S. , Astapenko O.O. , Lytovchenko N.M. , Palyvoda R.S.
Published: November 2023

The publication provides data from literary sources on the course of reparative processes in soft tissues and healing of skin wounds. The largest organ of the human body is the skin. It performs many extremely important functions. After traumatic damage to the skin, a complex cascade of cellular reactions occurs, which is unique in its nature. Since healing and regeneration processes occur in all parts of the human body, this review focuses on the processes of reparative changes in the skin. The first stage of acute wound healing is devoted to hemostasis and the formation of the previous wound matrix, which occurs immediately after the injury and ends in a few hours. In addition, this phase triggers the processes of an inflammatory reaction, the expressiveness of which depends on individual reactivity, the degree of microbial contamination of the wound, the type and nature of the lesion. Then, the proliferation phase begins, at this stage there is restoration of the wound surface, formation of granulation tissue and restoration of the vasculature. The third and final stage of wound healing is the remodeling phase, which usually begins 2-3 weeks after tissue damage. During this phase, the vessels of the granulation tissue are emptied, the number of fibroblasts sharply decreases, but instead, the number of elastic and, especially, collagen fibers increases. The continuous synthesis and destruction of collagen has the effect of remodeling the mature wound matrix for approximately 6 months after injury. At this stage, the formation and degradation of collagen balance each other, and there are no significant changes in its amount. The remodeling phase is most responsible for the volume of scar tissue formed. The aim of the work is to systematize the current literature data on the healing of soft tissue wounds. Conclusion. The analysis of the given data from the scientific literature shows that the regeneration of soft tissues is a complex process of body reactions that leads to the formation of scar tissue. Many pathophysiological processes underlying reparative reactions are still unknown.
History of the development of the science of the immune system
Authors: Melnyk V.V. , Kryvetskyi V.V. , Proniaiev D.V. , Yemelianenko N.R. , Voloshyn V.L. , Kuchuk O.P.
Published: November 2023

The immune system is a large network of organs, white blood cells, proteins (antibodies), and chemicals. This system works in concert to protect the body from foreign pathogens (bacteria, viruses, parasites, and fungi) that cause infection, disease, and illness. The human immune system works hard to stay healthy. Its task is to prevent the invasion of pathogens, destroy them or limit the extent of their damage if they enter. When the immune system is working properly, it can distinguish which cells are "own" and which substances are foreign to the body. It activates, mobilizes, attacks and kills foreign organisms that can harm human health. It is believed that the term "immunity" was used for the first time by Thucydides -  a prominent ancient Greek philosopher, historian, political scientist and military leader. For the first time, he discovered the resistance of a recovered person to a recurrence of the disease. Since that time, hundreds of outstanding scientists have devoted their lives to the study of extremely complex processes that occur in the human immune system during invasion. The invention of the vaccine became a significant impetus in the development of immunology as a science. In 1885, Pasteur administered the first vaccine to a human, a young boy who had been repeatedly bitten by a rabid dog. Immunology made significant progress in the late 19th century due to rapid developments in the study of humoral immunity and cellular immunity. In 1903, a humoral component known as an opsonin was discovered that makes target bacteria suitable for phagocytosis. Particularly important was the work of Paul Ehrlich, who proposed the side chain theory to explain the specificity of the antigen-antibody reaction. His contribution to the understanding of humoral immunity was recognized by awarding a joint Nobel Prize in 1908 together with the founder of cellular immunology, the Russian zoologist Ilya Mechnikov, who first formulated the phagocytic theory in 1880. Modern immunologists, using the tools of molecular and cellular biology, genomics, and proteomics, will take a step towards preventing fatal diseases. The world is expected to witness a further explosion of knowledge in the field of immunology in the coming decades. Collaborative efforts across subjects such as tumor immunology, autoimmunity, and vaccinology are needed to develop strategies to protect against multiple diseases.
Immunohistochemical features of ovarian cancer
Authors: Nikitina I.M. , Kopytsia T.V. , Sukhostavets N.P. , Kalashnуk N.V. , Babar T.V. , Herasуmenko S.F.
Published: November 2023

Ovarian cancer is the leading cause of death among women with gynecological oncological diseases. Diagnosis at the early stages of the disease allows for better chances of treatment and prognosis of ovarian cancer. It is reflected in the reduction of morbidity and mortality rates. An immunohistochemical study is used for differential diagnosis and accurate establishment of the histotype of ovarian cancer. Objective: to systematize literature data about the immunohistochemical features of ovarian cancer. In 90% of cases, ovarian cancer is epithelial-stromal, among which the main histological types are distinguished: serous (low- and high-grade), endometrioid, mucinous, and clear cell. In serous and other ovarian tumors, cytokeratins (CK) are widely used. CK 7 is present in all tumors, including mucinous tumors, expressing CK 20. Mucinous tumors also express villin and are negative for CDX-2. Endometrioid tumors react positively to vimentin, which is not observed in serous and mucinous tumors. Clear cell carcinoma expresses CK 8, 18, and EMA (epithelial membrane antigen).Conclusion. Therefore, immunohistochemical features of ovarian cancer ensure accuracy in the differential diagnosis of one or another histological type.
ОЦІНЮВАННЯ КОНКУРЕНТНИХ ПЕРЕВАГ ЕКОНОМІКИ РЕГІОНІВ УКРАЇНИ: ГАЛУЗЕВО-СЕКТОРАЛЬНИЙ АСПЕКТ
Authors: Лупак Р.Л.
Published: November 2023

У статті виділено важливість оцінювання конкурентних переваг економіки регіону, у результаті чоговдається сформувати повноцінну інформаційну базу в ході визначення та підбору інструментаріювирішення стратегічних завдань регіону. Аналіз низки наукових досліджень виявив, що серед науковцівнемає єдиної думки стосовно дотримання спільного методичного підходу до оцінювання конкурентнихпереваг економіки регіону. Оцінювання конкурентних переваг економіки регіонів України проведено ізвикористанням низки індикаторів з орієнтацією на галузево-секторальні тенденції. Притримуючисьіндексного методу здійснено розподіл регіонів України у відповідності до їх конкурентних переваг угалузево-секторальному вимірі. Зроблено висновки, що стратегічні цілі регіональної економіки Україниповинні бути пов’язані із вибудовуванням конкурентоспроможних комплексів динамічного розвитку звисоким рівнем інноваційності та технологічності.
Ключові слова: конкурентні переваги економіки регіону, конкуренція, конкурентоспроможність регіону,конкурентна позиція, галузь, сектор
ІННОВАЦІЙНО-ІНТЕГРОВАНИЙ ПІДХІД ДО УПРАВЛІННЯ ПІДПРИЄМНИЦЬКИМ ПОТЕНЦІАЛОМ РЕГІОНАЛЬНОГО РОЗВИТКУ
Authors: Погріщук Б.В. , Щербич В.В.
Published: November 2023

У статті досліджено питання управління підприємницьким потенціалом регіональногорозвитку на засадах інноваційно-інтегрованого підходу. Визначено, що інноваційні підходи вуправлінській діяльності відіграють важливу роль у процесі формування підприємницькогопотенціалу та забезпечують позитивні зрушення у напрямі підвищення регіональноїконкурентоспроможності. Інтегрованість розглядається через поєднання секторальної,територіальної та управлінської складових у процесі розробки заходів щодо управлінняпідприємницьким потенціалом регіонального розвитку. Доведено, що ефективне управлінняпідприємницьким потенціалом регіонального розвитку здійснюється шляхом його впливу нафінансову, інфраструктурну, кадрову, інноваційну та інші складові.

Ключові слова: управління, підприємницький потенціал, регіональний розвиток, інноваційно-інтегрований підхід, структуризація, децентралізація
METHODICAL WORK OF THE TEACHER AS A COMPONENT OF THE EDUCATIONAL AND PROFESSIONAL PROGRAM «SECONDARY EDUCATION (COMPUTER SCIENCE)»
Authors: Pavlova Nataliia
Published: November 2023

The purpose of the article is to determine the content and functions of the methodical work of an informatics teacher, justifying the need to reflect it in the cycle of professional training courses of the Secondary Education (Informatics) educational and professional program. Research methods: bibliosemantic (analysis, generalization of scientific and theoretical information for the purpose of studying the problem); system-analytical (analysis through synthesis, reasoning by analogy to present the main material); sociological (questionnaires of fourth-year students, observation of their studies, study of results); statistical methods (analysis and systematization of experimental data, their visual representation). The article considers the methodical work of a computer science teacher as a component of professional activity, defining it as a system of interrelated and interdependent actions aimed at competent goal setting, planning and organization of the educational process in computer science, as well as at increasing personal creativity and professional skills. The article presents the results of a survey of bachelors at the stage of graduation from a higher education institution regarding their ability and willingness to perform the methodological work of a teacher during: analysis of the pedagogical situation; designing teacher actions and students' learning and cognitive activities; using teaching tools, forms and methods; creating information projects. 72% of students surveyed believe that they are well prepared for the methodological work of a teacher, but could be better; 15% believe they are well prepared, while 6% and 7% believe they are «poorly prepared» and «not prepared». The methodological work of the teacher should be reflected as widely as possible in the educational and professional program «Secondary Education (Informatics)», in particular in the results of student learning, in the selection of disciplines, and in the creation of a professionally oriented learning environment. It is necessary to focus students on knowledge of the subject area, making informed decisions about the organization of computer science lessons, the use of innovative teaching methods and technologies, etc. The functions and principles of methodical work are outlined, based on the school course of computer science, computer science methods, didactics, pedagogy. Its purpose is formed from the goals of education and study of computer science, means – from the principles and content of pedagogical activity, and results – from the purpose and tasks of designing, organizing and implementing the process of studying a certain content area of computer science. Methodological work should be pedagogically appropriate in execution, creative in content, and balanced in the choice of teaching methods and tools.
CRITERIA AND INDICATORS OF THE LEVEL OF PROFESSIONAL COMPETENCE OF INFORMATION TECHNOLOGY SPECIALISTS
Authors: Sikora Yaroslava
Published: November 2023

The training of specialists under the conditions of the modern information society requires them to have a certain level of professional competence. The problem of formation and development of professional competence of future information technology specialists remains relevant. It is proposed to implement the process of developing this quality within the framework of the professional competence formation model, one of the stages of which is the diagnosis of the initial state of professional competence. The article specifies the concepts of "criterion", "indicator", "level"; general requirements for the criteria are defined. Based on the analysis of scientific and pedagogical research, regulatory documents, professional training experience, the criteria for the formation of the professional competence of future IT specialists have been identified, which reflect its structural components: motivational (level of formation of motives, needs, values regarding the performance of professional activities), content (availability of a knowledge system from the field of information technologies), technological (the degree of practical application of knowledge and skills when solving professionally oriented tasks) and subjective (professionally important qualities of a future specialist in information technologies and the ability to reflect on educational and professional activities). Formulated criteria made it possible to determine the relevant indicators. Four levels of formation of professional competence of future IT specialists are distinguished and substantiated: reproductive (initial), conscious (average), productive (sufficient) and creative (high). The further direction of research on this problem is the expansion of the diagnostic apparatus for assessing the level of formation of professional competence of future IT specialists.
MARKING OF THE STAGES OF DEVELOPMENT OF PROFESSIONAL TRAINING OF FUTURE TEACHERS OF THE UKRAINIAN LANGUAGE AND LITERATURE
Authors: Libak Natalka
Published: November 2023

The development of a periodization, which predicts the separation of the stages of development of the professional training of future teachers of the Ukrainian language and literature, is of great importance for retrospection analysis. The purpose of the study is to perform a theoretical analysis of the features of distinguishing the stages of periodization and markers that testify to the beginning of the stages of development of the professional training of future teachers of the Ukrainian language and literature, to clarify their specifics. To study the raised problem, methods of analysis, synthesis and generalization were applied, which enabled a comparative analysis of approaches to distinguishing the stages and main markers of the stages of development of professional training of future teachers of the Ukrainian language and literature. The analysis of the marking of the stages of the development of professional training of future teachers of the Ukrainian language and literature proves that only in isolated cases researchers clearly describe the markers for fixing the stages (T.Atroshchenko, T.Bondar, I.Haidai, L.Pasichnyk, O.Shkyr). In most of the reflected works, there is no marking of differentiated stages. The markers highlighted by the authors serve to indicate the stage within the developed periodization. The criterion for distinguishing a marker is the significance of its influence on the development of the next stage. Markers testify to the beginning of a new stage of development and make it possible to compare historical changes in the development of education. The results of the study show that the normative and legal framework is an objective marker, since the adoption of laws contributes to the development of a new stage and predicts changes in the functioning of domestic education.
El sujeto implicado en la novela española actual de memoria
Authors: Lauge Hansen Hans
Published: November 2023

A través de un análisis de la representación del sujeto implicado (Rothberg, 2019) en cuatro novelas españolas sobre la guerra civil, este artículo intenta discutir la tendencia de cierta crítica literaria española de categorizar la típica novela de memoria de la guerra civil como una novela despolitizante (novela de la no-ideología), frente a otro tipo de novela que se considera política o contra-hegemónica. La forma de representar el sujeto implicado se considera un índice del modo ético-político (Cento Bull y Hansen, 2016) con que la novela representa el pasado violento, y la distinción entre los tres modos fundamentales, el antagonista, el cosmopolita y el agonista, se presenta como un marco teórico para la categorización de la novela de memoria.
Minimal adverse events occur when inducing emesis with apomorphine in brachycephalic, mesocephalic, and dolichocephalic dogs
Authors: Harkins Ashlee E. , Iswara Arun Tharma , Jackson Kayla A. , Low Jolyn W. L. , Napier Elizabeth C. , Hickey Mara C.
Published: November 2023

OBJECTIVE

To determine risks of complications with emesis induction and whether facial conformation is associated with the frequency of complications.

ANIMALS

1,788 client-owned dogs that presented immediately or by referral from a primary care veterinarian following ingestion of toxic or foreign materials.

METHODS

Patients with emesis induced with apomorphine for removal of toxic or foreign materials were retrospectively identified. Collected data included patient factors, routes of apomorphine administration, other therapies, adverse events, and patient outcomes.

RESULTS

2 types of complications were identified in a very small number of patients (11 [0.6%]), with 3 (0.17%) having regurgitation postemesis and 8 (0.44%) having prolonged vomiting. No significant difference was found in the rates of repeated vomiting or regurgitation between brachycephalic dogs and nonbrachycephalic dogs (P = .375 and P = 1.00, respectively). Brachycephalic dogs had 1.6 times greater odds of having emesis induction due to toxin ingestion compared to foreign material ingestion. The presence of clinical signs of toxicity at the time of emesis induction was associated with regurgitation (P < .001), and the development of regurgitation was associated with admission to hospital (P = .001).

CLINICAL RELEVANCE

This study found no increased risk of complications when emesis was induced using apomorphine in brachycephalic breeds compared to nonbrachycephalic breeds, regardless of indication for emesis induction. Facial conformation is not a reason to withhold emesis induction.
Corrosion Resistance of NiS, ZnS and NiS/ZnS Thin Films Deposited by Spray Pyrolysis Technique on Low Carbon Steel in 3.5% Nacl Solution
Authors: Djail Kamel , Benramache Said
Published: November 2023

In this work, the main object of this research is to investigate a new material based on ZnS and NiS nanostructures. NiS and ZnS solutions were sprayed on the heated Low Carbon Steel by a spray pneumatic deposition method. Electrochemical analyses of the prepared samples were investigated. The high corrosion resistance of coated by ZnS sample have a low value of surface roughness. However, the coated sample by ZnS also has good stabilization after corrosion and high compact of the film.
Selected psychological aspects of qualifying candidates for divers and scuba divers
Authors: Wolański Władysław , Pełka Stanisław , Ramisch Józef
Published: November 2023

The article presents the results of a pilot programme to include psychological tests in the qualification rules for candidates for military divers and scuba divers. 207 candidates for training at the Polish Army Divers and Scuba Divers Training Centre were tested. They were subjected to mental fitness tests, personality tests, psychomotor fitness tests and general fitness tests. Numerous psychological contraindications to undertaking training and diving service were identified; the most common issue identified being a lack of robustness of the diver’s mental state for dealing with the situations likely to be encountered in the water. The conclusions suggest that, as in other countries, psychological examinations should be included in the qualification of candidates for diving. The results of the tests, despite their non-mandatory nature, were partly taken into account in the opinion of the Military Maritime and Medical Commission.
The Passive across Two Registers of Present-Day British English: A Corpus-Based Lexico-Grammatical Perspective
Authors: Malá Markéta , Ježková Zuzana
Published: November 2023

This paper explores the use of the passive in present-day British English, focusing on its register-specific lexico-grammatical patterns. The interaction of the grammatical structure, lexis, phraseology and register is examined on the basis of two sub-corpora of the British National Corpus 2014 – academic prose and informal conversation. The results have corroborated the findings of previous studies in that the pattern ‘BE / GET V-ed’ is populated by verbal participial forms which create a cline with departicipial adjectives. The communicative needs of registers have been shown to have a decisive impact on the frequency of passive patterns and the specific lexical choices associated with the patterns. In both registers, the ‘BE / GET V-ed’ patterns appear to constitute the core of larger fixed phraseological units, e.g., can’t be bothered to/with, or it should be noted that.
Technical and Economic Feasibility of Controlled Release Fertilizer in Production Coffee Crop
Authors: Fernandes André Luís Teixeira , Tavares Tiago de Oliveira , Mosca Eduardo , Ferreira Rodrigo Ticle , Simão Luvas Alves
Published: November 2023

Objective: To evaluate the performance of a controlled release fertilizer on the vegetative and productive development of coffee trees in production.
 
Theoretical framework: The use of slow, controlled release fertilizers or smart fertilizers can allow the reduction of fertilization operations, in addition to being characterized by the availability of nutrients to plants at the correct time, with the consequent reduction in maintenance expenses, labor of work and fuel.
 
Method: A trial was conducted in Alto Paranaíba, Minas Gerais, during 4 harvests, to evaluate the performance of a slow-release fertilizer on the vegetative and productive development of coffee trees in production, as well as the impacts of this technology on the scaling of mechanized operations in property.
 
Results and conclusion: With the use of slow-release fertilizers, it was concluded that: slow-release potassium nutrition reduces the competitive effect of potassium with Calcium and Magnesium; productivity gains are obtained when compared to the use of conventional fertilizers; there is an increase in coffee yield; at a rate of 80% of the dose, there are advantages in the nutrition of the coffee plant, especially in old crops; There is a reduction in the number of machine hours worked in the agricultural year with a consequent reduction in production costs, making it possible to redistribute mechanized operations, reducing labor and the volume of operations in the months that demand the most services.
 
Implications of the research: With the results of the research, over two biennia, it was possible to identify the positive factors of using slow-release fertilizers for coffee trees, both in biometric and productive aspects and in the optimization of mechanized operations in a coffee farm cultivated in the cerrado miner.
 
Originality/value: a better understanding of the effects of using slow-release fertilizer technology to increase productivity and better economic and environmental performance in coffee agribusiness.
The study of the influence of pharmacotechnological and economic factors on the pharmaceutical development of capsules with trimetazidine for the treatment of cardiovascular diseases
Authors: Zlahoda V. S. , Bobrytska L. O.
Published: November 2023

Cardiovascular diseases are the main cause of reduced life expectancy and quality in the modern world.
Aim. To study the influence of pharmacotechnological and economic factors on the pharmaceutical development of capsules with trimetazidine for the treatment of cardiovascular diseases.
Materials and methods. The research material was the medicinal substance trimetazidine (SharonBio-Medicine Ltd., India), excipients used in the technology of solid dosage forms.
The study of pharmacotechnological characteristics was carried out on devices of the company “Pharma Test” (Germany). The fluidity and the angle of repose were measured on a VP-12A device. The fluidity was estimated by the Carr Index of powder compressibility and the Hausner Index coefficient. A comparative analysis of the cost calculation of the production of drugs with trimetazidine in tablet and capsulated forms was carried out using the “costs plus” method.
Results and discussion. As a result of the studies conducted on the selection of excipients for capsules with trimetazidine, the following excipients were reasonably used: lactose monohydrate 200/25 diluent, mannitol PARTECK M 200 filler and CompactCel®MAB mixture of a disintegrant, a moisture regulator and a lubricant.
A comparative analysis of the cost calculation of the production of drugs with trimetazidine in tablets and capsules was carried out.
Conclusions. The advantages of direct encapsulation technology by economic and technological indicators prove the economic efficiency and contribute to new developments of high-quality medicinal products in capsules with high efficiency, availability and ease of use.
The main aspects of effective internal audits of the energy management system in health care institutions
Authors: Nosachenko M. P. , Kovalenko S. M.
Published: November 2023

Aim. To analyze the main components of conducting and forming recommendations for the effective implementation of internal audits of the energy management system in healthcare institutions.
Materials and methods. To achieve the goal, we applied such methods as informative, retrospective, analytical ones based on the study of scientific literature, materials of Internet-resources and our own conclusions regarding the results of the work carried out.
Results and discussion. The article analyzes the main aspects of effective implementation of internal audits of the energy management system in healthcare institutions. It has been shown that internal audits are not conducted effectively and do not add the expected value. The causes for low performance have been analyzed and systematized. It has been proven that the problem of improving the effectiveness of internal audits of the energy management system should be solved systematically, using the methods and approaches developed by the authors and proposed in the article.
Conclusions. Internal audits of the energy management system should be given closer attention in each healthcare institution since a properly organized audit process is an effective tool for analyzing the energy management system and provides important and relevant information for timely corrective and preventive actions.
Marketing analysis and positioning of diuretic medicines at the pharmaceutical market of Ukraine
Authors: Malyi V. V. , Malinina N. G. , Rohulia O. Yu. , Babicheva G. S. , Bondarieva I. V. , Chehrynets A. А.
Published: November 2023

Aim. To perform the marketing analysis of the domestic pharmaceutical market in the segment of diuretic medicines and study the directions of their positioning.
Materials and methods. The research materials are data from the State Register of Medicines of Ukraine and the Electronic Medicines Compendium. To achieve the goal, the methods of logical and meaningful problem formation, desk market research, comparative analysis, content analysis of scientific and practically oriented medical and pharmaceutical publications were used.
Results and discussion. The article presents the results of the marketing analysis of the domestic pharmaceutical market of diuretic medicines of group C03 “Diuretics” registered at the pharmaceutical market of Ukraine as of July 1, 2023. It has been determined that the range of diuretic medicines includes 124 trade names analyzed by INN, the number of trade names, by production, dosage form, price range, availability in the assortment of pharmacies. The analysis of the market of the group of medicines studied by producing countries, form of release and conditions of dispensing from pharmacies has been performed, as well as positioning has been carried by the peculiarities of the use of diuretics by such consumer segments as children, women during pregnancy and lactation. The INNs of medicines, which content are not offered by domestic manufacturers, have been identified, and therefore they can be considered promising for updating the product range.
Conclusions. The results of the marketing analysis of the diuretic market and development of positioning directions are the basis for the search and development of new effective domestic medicines for the treatment and prevention of renal failure, neurological and cardiac diseases and other diseases in the pharmacotherapy of which diuretics are used.
The connection of the generations of Dmytro Pavlovych Salo technological school
Authors: Vishnevska L. I. , Semchenko K. V. , Ruban О. А. , Polovko N. P. , Kukhtenko O. S.
Published: November 2023

Aim. To study the development of the technological scientific school from the time of D. P. Salo to the present.
Materials and methods. Analytical, comparative and logical methods of research, as well as data from scientific literature, were used in the work.
Results and discussion. The development of the technological school through the prism of generations from D. P. Salo to the modern technological school of the National University of Pharmacy was studied.
Conclusions. The Department of Pharmaceutical Technology of Drugs of the National University of Pharmacy continues the good traditions of the technological school founded in the time of D. P. Salo, and actively introduces new modern trends in education and research.
The study of the pharmacological activity of a cream with a white willow bark extract on the model of contact non-allergic dermatitis
Authors: Pidgaina V. V.
Published: November 2023

Despite the achievements of medicine, dermatological skin diseases are an urgent problem today as the incidence rate increases annually. A promising direction of modern pharmacotherapy of dermatoses is the creation of innovative etiotropic topical agents on a plant basis.
Aim. To study the pharmacological activity of a combined cream with a white willow (Salix alba L.) bark extract and zinc perithionate under the conditional name “Pyrisalix” against the background of the experimental non-allergic dermatitis induced by turpentine oil.
Materials and methods. As the study object, a cream made with the active substances of a thick extract of white willow bark and zinc perithionate on a cream base was used; it corresponded to the pharmacotechnological indicators by colloidal, thermal stability and the description of oil/water (20 % of the oil phase). The model of alternative chronic inflammation, non-allergic contact dermatitis, was induced in white non-linear rats by daily application of turpentine oil to the depilated area. The effectiveness of the “Pyrisalix” cream was evaluated based on the total leukocyte count, the peripheral blood leukocyte composition, erythrocyte sedimentation rate (ESR), including the leukocyte-ESR ratio index (LI-ESR), the skinfold thickness, and the skin cover condition. In our experiment, the phagocytic activity of granulocytic neutrophils in a leukocyte suspension obtained from heparinized blood was determined to assess the activity of nonspecific immune factors.
Results. The emulsion base of the cream has been determined, according to which the product developed has thermal and colloidal stability. In the course of studying the pharmacological activity of the “Pyrisalix” cream on themodel of non-allergic skin inflammation based on the dynamics of local manifestations of contact dermatitis, hematological, and immunological parameters, it has been found that the “Pyrisalix” cream has a pronounced preventive and therapeutic effect due to its anti-inflammatory and immunological properties. In the experimental conditions, the anti-alterative action of the cream on the emulsion oil/water base studied was equal to or even significantly exceeded the activity of the reference drugs – “Fladex” ointment and “Psorikap” cream by the intensity of inhibition of inflammatory processes in the skin, reduction in total leukocyte count, and normalization of the functional activity of granulocytic neutrophils.
Conclusions. The combined cream “Pyrisalix” on the emulsion oil/water base demonstrates a significant antiinflammatory activity on the model of non-allergic contact dermatitis. The combined cream “Pyrisalix” is a promising agent for further study in the treatment of dermatoses.
Pulmonary Embolism with Negative D-Dimer
Authors: Saleh Syed
Published: November 2023

Venous thromboembolism is condition characterized by the presence of blood clot that resides in the venous system. It encompasses deep vein thrombosis which is represented by development of de novo blood clot in the deep venous system of the limbs (commonly lower limbs) and pulmonary embolism, which emerges as the preformed blood clots mobilize and occlude the pulmonary circulation. Here, we present a case of a 44 year old lady who was diagnosed with pulmonary embolism proven by CT pulmonary angiogram despite having a negative d-dimer assay.