bluuebunny/crossref_metadata_2025 huggingface dataset:
In silico prediction of flavan-3-ol as a bioactive compound of Calophyllum macrophyllum as a potential drug against angiostrongylus eosinophilic meningitis
Authors: Hambal Muhammad , Frengki Frengki , Sari Wahyu Eka , Vanda Henni
Published: May 2022

Background and Aim: Angiostrongylus eosinophilic meningitis is caused by larvae of the rat lungworm Angiostrongylus cantonensis. It manifests as meningitis, radiculitis, cranial nerve abnormalities, and encephalitis, which can be fatal. A flavan-3-ol compound isolated from the bark of Calophyllum macrophyllum Scheff. has several medicinal properties, including antioxidant, anti-inflammatory, antidiabetic, and antibacterial activities. This compound is stronger than other types of flavan-3-ols such as catechin. This study aimed to identify the hydroxylation pattern of this flavan-3-ol compound and evaluated its potential as an anti-meningitis drug, using an in silico approach through pharmacophore and molecular docking methods.

Materials and Methods: Pharmacokinetic and toxicological data were analyzed and supported by the server http://www. swissadme.ch/index.php and https://tox-new.charite.de/protox_II/index.php. The hydroxylation pattern of the flavan-3-ol compound was identified using shear reagents (MeOH, NaOH, NaOAc, HCl, and AlCl3). The CviR receptor (pdb id.3QP5) was used in the in silico approach, and seven ligands were downloaded from PubChem in "SMILES" format.

Results: The spectroscopic analysis conducted using the shear reagents confirmed that the flavan-3-ol compound has a "p-diOH" pattern on the cinnamoyl ring. Pharmacophore analysis revealed this compound "hit" with pharmacophore features, and molecular docking analysis showed that this compound has a strong affinity with both receptors.

Conclusion: The flavan-3-ol compound is a potential drug candidate for meningitis caused by pathogenic bacteria and the worm A. cantonensis. This result was supported by the pharmacokinetic profile, which had a very low toxicity level to the host. However, further investigation is required to confirm the data in vitro and in vivo.
Effects of environmental condition, size, coat type, and body condition score on rectal temperature prediction in dogs using infrared auricular and surface temperature
Authors: Lukkanawaraporn Yanisa , Tiangtas Nutnicha , Chaikornkij Vorapan , Nawapakpilai Patthamon , Areerat Sathita , Chundang Pipatpong , Lekcharoensuk Chalermpol , Kovitvadhi Attawit
Published: May 2022

Background and Aim: Generally, rectal body temperature (BTrectum) is used to prefer as core body temperature in dogs. However, this procedure is time- and labor-consuming with stress induction. Therefore, infrared auricular temperature (BTear) and surface temperature (ST) could be applied to estimate BTrectum. This study aimed to estimate BTrectum from BTear or ST in various areas and determined the factors that influenced the accuracy of prediction equations.

Materials and Methods: Under controlled temperature (n=197) and ambient temperature (n=183), the parameters BTrectum, BTear, and ST at internal pinna, auricular canal, lateral aspect of shoulder, hip, axillary area, inguinal area, footpad, and anal area (STrectum) were measured. In addition, temperature and humidity levels of the surrounding environment were recorded. The correlation between each measurement technique was calculated. The BTrectum prediction equation was created using all measured data and several influencing factors (environmental condition, size, coat type, and body condition score [BCS]).

Results: The highest correlation with BTrectum was observed for BTear (r=0.61, p<0.01), which was similar to STrectum (r=0.61, p<0.01). Based on multiple linear regression model results using BTrectum as the dependent variable, BTear or STrectum were first selected as independent variables in all estimation equations. Ambient temperatures (R2=0.397), small breed (R2=0.582), long hair (R2=0.418), and/or a BCS of 2 (R2=0.557) provided the highest coefficients of determination of the prediction equation.

Conclusion: The most appropriate predictors for estimating BTrectum were STrectum and BTear, which were impacted by the dog's signalments and the environment. To obtain satisfactory outcomes, the equation must be selected depending on the dog's signalments and the environmental conditions. However, based on the findings of this investigation, the accuracy remains low in several equations, and further studies are needed to improve the accuracy of the equation, mainly by increasing the sample size and developing a specific equation for each dog's signaling and environmental condition.
APONTAMENTOS TEÓRICOS DA FENOMENOLOGIA COMO (POSSÍVEL) CAMINHO METODOLÓGICO PARA PESQUISAS EM EDUCAÇÃO NÃO ESCOLAR
Authors: Vianna Ferreira Arthur
Published: May 2022

O presente artigo tem como objetivo discutir como a ﬁ losoﬁ a fenomenológica de Edmund Husserl (1958; 1975) pode servir de inspiração à construção de um caminho epistemológico para pesquisas sobre práticas educativas em espaços não escolares. Para isso, traz a reﬂ exão de alguns autores a respeito dessa ﬁ losoﬁ a, como Salansky (2006), Depraz (2011) e Ferreira (2015) e, particularmente, o desenvolvimento de três conceitos considerados relevantes para a análise da realidade educacional como um fenômeno social: o noema, a noese e a variação eidética como doação de sentido da realidade pelos sujeitos dos processos de ensino-aprendizagem. Ao ﬁ nal, o artigo mostra o emprego desses aspectos da Fenomenologia e seus resultados em algumas pesquisas sobre educação e pobreza que  utilizaram esse percurso metodológico.
(A)NORMALIDADES CORPORAIS E AS (IN)VISIBILIDADES ESPORTIVAS
Authors: Camargo Wagner Xavier
Published: May 2022

O esporte moderno já tem um percurso estabelecido que permite compreender seu modus operandi, particularmente no tocante à visibilidade da normalidade, à sincronia proposital entre corpos, gêneros e sexualidades e ao estabelecimento do rendimento esportivo, por meio do emprego de técnicas 'precisas' e ‘corretas’. A proposta deste texto é trazer casos de atletas que apareceram na história do esporte durante o século XX, a fim de edificar três problematizações trazidas por tais corpos, sendo elas: a) dissonâncias de gênero não visibilizadas tendem a apagar existências de registros oficiais; b) é nas modalidades esportivas mais conhecidas e valorizadas pela cultura ocidental que mais se identifica tal invisibilidade em comparação com esportes desconhecidos; e c) o nível de performance esportiva contribui para manter os ‘casos de exceção’ escondidos: quanto melhor a performance, mais um corpo tende a ser normalizado. A partir de uma analítica das variáveis ‘gênero’, ‘visibilidade’ e ‘nível de performance’ conclui-se que o próprio sistema se encarrega de estabelecer as (a)normalidades corporais e manter as invisibilidades esportivas para a manutenção do status quo.
MAQUINARIA CORPORAL: EFICIENCIA Y ESTÉTICA EN EL DEPORTE PARALÍMPICO
Authors: Torri Danielle , Piriz Rodrigo , Vaz Alexandre
Published: May 2022

El artículo aborda la constitución de los cuerpos deportivos en una doble clave: la pareja eficiencia-discapacidad y la posibilidad de expresión estética. Para ello, tiene en cuenta los resultados de una encuesta sobre la práctica del básquetbol en silla de ruedas. Por tanto, considera el papel de la tecnología como determinante de las prácticas, componiendo el sujeto y tornando lo que sería su naturaleza (que nunca se podrá determinar) un complemento de la máquina. Si el deporte presupone el dominio del cuerpo -o su producción como dominio propio del sujeto-, la maquinaria que se incorpora puede producir una expresión estética que trascienda el dominio que el sentido común atribuye a menudo al paralimpismo: grotesco. El dominio técnico y táctico, aliado a la habilidad de manejar la silla, puede generar nuevas experiencias estéticas, insospechadas porque a partir de la deficiencia es que se quiere la eficiencia. Esa estética, tan necesaria, tiene por tanto su costo, que es la reducción del cuerpo a instrumento. La paradoja no es exclusiva del deporte paralímpico, sino que es lo que lleva, a sus últimas consecuencias, las formas y usos del cuerpo deportivo.
LA REPRESENTACIÓN DEL CUERPO MASCULINO COMO DISPOSITIVO DE PROPAGACIÓN DE UN IDEAL
Authors: Collelldemont Pujadas Eulàlia , Cercós Raichs Raquel
Published: May 2022

El artículo aborda la representación de la formación del género masculino como estereotipo a través del análisis de los documentales y noticiarios oficiales del régimen franquista (1939-1975) contrastado con las imágenes y discursos difundidos en revistas y manuales. Con una aproximación de análisis de contenidos visuales, se presentan tres de los ejes que condicionaron la normalidad del aprender a ser hombre: la vigorosa obediencia, la hipermasculinidad como utopía física a alcanzar y el control de si mismo y cuidado vigilante del compañero como único comportamiento aceptado. Visualizando cómo se mostraron estos ejes se perfila un proyecto formativo vital que quedó como fundamento estructural del tópico español.
EDUCAÇÃO DO CORPO, DOPING E ESPORTE NO FILME “O PROGRAMA: A VERDADEIRA HISTÓRIA DE ARMSTRONG”
Authors: Zoboli Fabio , Correia Elder Silva , Dantas Junior Hamilcar Silveira
Published: May 2022

O presente escrito tem como objetivo interpelar a educação do corpo, na obra cinematográfica “O programa: a verdadeira história de Lance Armstrong” (2015), a fim de reflexionar os usos do corpo no esporte moderno, sob a política do doping. A crítica que se quer sustentar, com esta análise, é que a técnica é o meio pelo qual o humano reingressa no devir da própria natureza, de tal modo que o humano é uma expressão de tal atividade. Isso implica considerar que os limites do doping não podem ficar presos a uma ontologia, na qual o corpo é dado como algo puro e que sua natureza é oposta ao que se entende por artificial. No entanto, isso não significa dizer, necessariamente, que se é favorável ao doping no esporte. Conclui-se que o esporte está tão imerso a códigos morais, a juízos preexistentes, que é pouco sensível e capaz de perceber que, na prática, as performances dos corpos dos atletas na sua estreita relação com tecnologias, expressam a natureza e sua lógica da mútua inclusão.
Biophysical investigations of single cells with optically actuated microtools
Authors: Fekete Tamás
Published: May 2022

Dolgozatomban azt mutatom be, hogy optikai csipeszen alapuló technikák hogyan használhatóak élő sejtek fizikai, illetve biokémiai tulajdonságaik vizsgálatára. Az általunk használt módszer segítségével élő endothél sejtek Young modulusa és sejtekhez felületéhez történő adhézió erőssége is meghatározható. Ezekhez a kísérletekhez precízen mozgatott kétfotonos polimerizációval készült feladatorientáltan tervezett SU-8 mikromanipulátorokat használtam. Munkám során megmértem glutationnal kezelt felületek adhéziós erejét agyi endothél sejteken, az általunk bemutatott optikai csipeszen alapuló mérési technikánkat adaptálva a tapadási erő mérésére. A kísérletek során használt SU-8 mikromanipulátorok, képesek minimalizálni a csapdázó lézer sejtet károsító hatásait, továbbá a lézeres mikrofabrikáció lehetővé teszi, hogy a kísérleti elrendezéshez a legmegfelelőbb geometriájú szondát készítsünk. Mindkét kísérlet sorozatban olyan elrendezést használtunk, melyben a sejtek egy maszk-litográfiával készült falakra voltak növesztve, mely lehetővé tette, hogy az optikai tengelyre merőlegesen tudjuk mérni az elaszticitásukat vagy az adhéziós erőt, a csapdázott mikromanipulátorokat laterálisan mozgatva. Az általunk bemutatott módszer kiterjeszthető lesz, hogy megkülönböztethetőek legyenek egyes és dupla tapadási események, mellyel információt kaphatunk a vér-agy gátat targetáló ligandumok adhéziós erejéről élő sejteken. Valamint a funkcionalizációs protokollban szereplő PEG-linker módosításával könnyűszerrel több tucatnyi célmolekula immobilizálható a mikrostruktúra felületére.
Plant's defense systems and biocontrol methods in aspect of plant-pathogen interactions
Authors: Sen Susmita
Published: May 2022

Plants suffer from attack of various pathogen like fungi, bacteria which causes wilting of leaves, destruction of plant parts especially the shoot system and many more. However, just like humans exhibit immune responses against any pathogenic attack in the body, plants too exhibit such features. Plants secrete certain secretome proteins in their apoplastic regions which is one of the defence system played by plants to stop the invasion of pathogen inside the plant body. The microbial elicitors also known as Pattern-associated molecular patterns (PAMPS) are recognised by membrane-localised pattern recognition receptors (PRR) of plants.
PsychoEducation Tensor Interventional Poster
Authors: Sheppard Joseph Z.
Published: May 2022

The PsychoEducation Tensor Interventional Poster was designed to illustrate relationships between sixteen elementary mental processes. Moreover, the PsychoEducation Tensor (PET) is described as one of seven primary tensors describing all scientifically measurable phenomena. PET is adapted from EM-Theory as a minimalist model of global cognition.
Análise dos fatores de Atração e retenção de profissionais médicos da estratégia da saúde da família na região oeste de Minas Gerais
Authors: Soares Cíntia
Published: May 2022

O objetivo deste artigo foi identificar fatores que facilitam a atração e a retenção dos profissionais médicos na Estratégia de Saúde da Família (ESF) em municípios da região oeste de Minas Gerais.Através de metodologia descritiva qualitativa, os resultados encontrados  apontam como fatores de atração para o trabalho na ESF: identificação com o tipo de trabalho, porta de entrada no mercado de trabalho enquanto se aguarda a residência, admiração pelo tipo de trabalho e incentivo para esta área desde a graduação.  Os fatores de retenção identificados foram a percepção da remuneração, compatibilidade com outra atividade remunerada; satisfação profissional; vínculo na contratação; curso de formação e aperfeiçoamento; estado civil; forma de ingresso; faixa etária; tempo de formado; quantidade de filhos. Os fatores de não retenção foram: oferta de emprego com melhor remuneração, entrada na residência e falta de valorização da ESF. Os resultados apontam a necessidade de se refletir sobre as diferentes ações públicas visando tanto fortalecimento da estratégia de saúde quanto de medidas voltadas à gestão de profissionais de saúde que favoreçam sua atração e retenção neste modelo.
Enfermagem na APS: contribuições, desafios e recomendações para o fortalecimento da Estratégia Saúde da Família
Authors: Nunciaroni Andressa Teoli , Cunha Carlos Leonardo Figueiredo , Borges Flávio Adriano , Souza Inês Leoneza de , Koster Isabella , Souza Isadora Siqueira de , Silva Lucélia dos Santos , Ferreira Sandra Rejane Soares
Published: May 2022

Esta Nota Técnica foi produzida no âmbito da Rede de Pesquisa em Atenção Primária à Saúde da Associação Brasileira de Saúde Coletiva (Abrasco) com o propósito de colaborar para o desenvolvimento da agenda estratégica da Rede. Participaram de sua elaboração representantes da Associação Brasileira de Enfermagem de Família e Comunidade (Abefaco) e Associação Brasileira de Enfermagem (ABEn).

O documento com a temática Enfermagem na Atenção Primária à Saúde (APS) faz parte de um conjunto de outras notas da Rede e tem por objetivos: apresentar um retrato sobre a atuação da Enfermagem e suas contribuições para o fortalecimento da Estratégia Saúde da Família (ESF) no Brasil; e tecer recomendações que permitam o seu desenvolvimento, a partir dos elementos críticos do contexto atual do país que interferem nas atividades profissionais.

Ao longo do tempo, a Enfermagem apresenta uma participação sociopolítica importante na construção da APS, em conjunto com as demais profissões da área da saúde. Sua atuação exibe elementos significativos que colaboram com o desenvolvimento dos atributos da APS, sobretudo se tomar a ESF como modelo prioritário para o Sistema Único de Saúde (SUS). Contudo, destaca-se que a profissão, apesar de seus esforços, devido à estrutura sociopolítica e econômica, ainda não obteve o reconhecimento e a visibilidade merecidos.

A partir dessa produção, alguns pontos-chave podem ser destacados:

A centralidade da ESF como modelo prioritário para uma Política Nacional de Atenção Básica (PNAB) que fortaleça a APS e a universalidade do SUS.

A Enfermagem na contribuição e consolidação da ESF pela amplitude de áreas de atuação e escopo de práticas.

A estrutura social, política e econômica, que traz implicações diretas à Enfermagem, com prejuízo para o seu desenvolvimento, relacionado à gestão do trabalho, formação, atuação e reconhecimento social.

A PNAB de 2017, que trouxe repercussões críticas para o processo de trabalho das equipes de saúde da família (eSFs), assim como para a Enfermagem.

A compreensão de que o campo da gestão do trabalho e educação na saúde, a participação sociopolítica da Enfermagem e o fortalecimento de sua especialidade na APS podem impulsionar a agenda estratégica da Rede de Pesquisa em APS da Abrasco, assim como outras iniciativas.

A relevância em alcançar os Objetivos de Desenvolvimento Sustentável (ODS) na atuação profissional pelas eSFs.
Sozialraumorientierung in der Altenhilfe: Auf der Suche nach Antworten auf die Pflegekrise
Authors: Metzger Jonas
Published: May 2022

Jonas Metzger widmet sich in diesem Beitrag der Bedeutung des Sozialraums für das Alter(n). In Anbetracht einer sich anbahnenden Pflegekatastrophe und der Behäbigkeit der Pflegereformen ist inzwischen klar, dass der entstehende Unterstützungsbedarf für Menschen mit Demenz von den aktuellen Unterstützungsstrukturen (sowohl den professionellen, als auch den informellen) kaum bewältigt werden kann. In diesem Aufsatz wird die Bedeutung des Sozialraums für eine alternde Gesellschaft sowie die Möglichkeit mit Hilfe der Sozialraumorientierung neue und vielfältige Perspektiven auf das Alter(n) im Quartier zu kultivieren diskutiert und reflektiert.
Ehrenamt und Demenz im städtischen Raum: Das Praxisbeispiel Martinsviertel in Darmstadt
Authors: Träger Jutta , Groß Christopher
Published: May 2022

Jutta Träger und Christopher Groß zeigen mit der Sozialraumanalyse auf, wie ehrenamtliche Strukturen und nachbarschaftliche Hilfen in Darmstadt gestärkt werden können, um die Lebenslage älterer Menschen mit Demenz zu verbessern. Mithilfe sozialraumanalytischer Methoden werden die Bedarfe von Menschen mit Demenz in einem städtischen Quartier erfasst und auf Basis der Ergebnisse Handlungsempfehlungen für Politik und Gesellschaft entwickelt, die Betroffenen einen möglichst langen Verbleib in ihrem Wohnquartier ermöglichen sollen.
(Post) Colonial Streaming: The Social Reproduction of Listening and Deafness in the Anthropocene
Authors: Souza Lima Henrique
Published: May 2022

In this article, Henrique Souza Lima is dedicated to unfold the concept of 'regime of listening' through the analysis of a particular aspect of the listening culture driven by Big Data and AI. The discussion gravitates around the thesis that the current majoritary regime of listening implies a particular type of deafness, insofar as there is much to hear, but the presence of the Anthropocene remains barely heard.
Passageways of Knowing. Music, Movement, Reconnection
Authors: Abels Birgit
Published: May 2022

In this contribution, Birgit Abels explores music-making as a knowledge practice that can teach us a lot about a postcolonial world where hegemonic and disenfranchised epistemologies compete. Music ›is‹ not; music is only ever becoming, and that becoming interlaces with our own becoming. In music's evanescence lies its efficacy. Process-philosophically, the efficacy of music can never be categorical: a signified, a given or purely subjective (however defined). Instead, music affects, and interacts with, the felt body as a continuous, amorphous stream of layered complexity. This complexity straddles the territorial boundaries of the material and the immaterial, of the referential and the essential; and, it is deeply relational in nature. Outlining music-making's relational capacities through the terms ›sound knowledge‹ and ›sound work‹, in this contribution, Abels will quickly arrive at the atmospheric workings of sonic practices. We know through music not least atmospherically, and we act on that knowledge in ways that cannot possibly be pinned down to either the signified or the sonically essential. Exploring music-making in terms of sound knowledge, she argues, has the potential to open up post- colonial studies' much lamented, but nonetheless persistent heavy textual bias in favour of a more encompassing consideration of cultural practices.
The Vibration of a Simply Supported Visco-Thermoelastic Nano-beam of Silicon Nitride Induced by Thermal Shock
Authors: Alghamdi Najat A. , Alosaim Aeshah A.
Published: May 2022

In this article, the vibration of visco-thermoelastic isotropic homogeneous nano-beam has been studied. A general model of visco-thermoelasticity theory under simply supported conditions of one relaxation time has been used. The Laplace transformation has been applied for the governing equations. The inverse Laplace transformation has been considered by using Tzou procedure. When subjected to thermal shock loading and simply supported conditions, the numerical results have been validated for a visco-thermoelastic rectangular nano-beam of silicon nitride. Figures of this paper represent numerical results to describe the effects of the visco-thermoelastic parameters and the thickness of the nano-beam. The beam’s thickness and the visco-thermoelastic parameters have been significant effects on all the studied state-functions.
Discontinuous Petrov–Galerkin Approximation of Eigenvalue Problems
Authors: Bertrand Fleurianne , Boffi Daniele , Schneider Henrik
Published: May 2022

In this paper, the discontinuous Petrov–Galerkin approximation of the Laplace eigenvalue problem is discussed.
We consider in particular the primal and ultraweak formulations of the problem and prove the convergence together with a priori error estimates.
Moreover, we propose two possible error estimators and perform the corresponding a posteriori error analysis.
The theoretical results are confirmed numerically, and it is shown that the error estimators can be used to design an optimally convergent adaptive scheme.
Comprehensive narrative review of real-world COVID-19 vaccines: viewpoints and opportunities
Authors: Liu Shelan , Kang Min , Zhao Na , Zhuang Yali , Li Shijian , Song Tie
Published: May 2022

Currently, people all over the world have been affected by coronavirus disease 2019 (COVID-19). Fighting against COVID-19 is the top priority for all the countries and nations. The development of a safe and effective COVID-19 vaccine is considered the optimal way of ending the pandemic. Three hundred and 44 vaccines were in development, with 149 undergoing clinical research and 35 authorized for emergency use as to March 15 of 2022. Many studies have shown the effective role of COVID-19 vaccines in preventing SARS-CoV-2 infections as well as serious and fatal COVID-19 cases. However, tough challenges have arisen regarding COVID-19 vaccines, including long-term immunity, emerging COVID-19 variants, and vaccine inequalities. A systematic review was performed of recent COVID-19 vaccine studies, with a focus on vaccine type, efficacy and effectiveness, and protection against SARS-CoV-2 variants, breakthrough infections, safety, deployment and vaccine strategies used in the real-world. Ultimately, there is a need to establish a unified evaluation standard of vaccine effectiveness, monitor vaccine safety and effectiveness, along with the virological characteristics of SARS-CoV-2 variants; and determine the most useful booster schedule. These aspects must be coordinated to ensure timely responses to beneficial or detrimental situations. In the future, global efforts should be directed toward effective and immediate vaccine allocations, improving vaccine coverage, SARS-CoV-2 new variants tracking, and vaccine booster development.
Programmable chalcogenide-based all-optical deep neural networks
Authors: Teo Ting Yu , Ma Xiaoxuan , Pastor Ernest , Wang Hao , George Jonathan K. , Yang Joel K. W. , Wall Simon , Miscuglio Mario , Simpson Robert E. , Sorger Volker J.
Published: May 2022

We demonstrate a passive all-chalcogenide all-optical perceptron scheme. The network’s nonlinear activation function (NLAF) relies on the nonlinear response of Ge2Sb2Te5 to femtosecond laser pulses. We measured the sub-picosecond time-resolved optical constants of Ge2Sb2Te5 at a wavelength of 1500 nm and used them to design a high-speed Ge2Sb2Te5-tuned microring resonator all-optical NLAF. The NLAF had a sigmoidal response when subjected to different laser fluence excitation and had a dynamic range of −9.7 dB. The perceptron’s waveguide material was AlN because it allowed efficient heat dissipation during laser switching. A two-temperature analysis revealed that the operating speed of the NLAF is

≤
1

$\le 1$

ns. The percepton’s nonvolatile weights were set using low-loss Sb2S3-tuned Mach Zehnder interferometers (MZIs). A three-layer deep neural network model was used to test the feasibility of the network scheme and a maximum training accuracy of 94.5% was obtained. We conclude that combining Sb2S3-programmed MZI weights with the nonlinear response of Ge2Sb2Te5 to femtosecond pulses is sufficient to perform energy-efficient all-optical neural classifications at rates greater than 1 GHz.
The crystal structure of 1,2-bis(pyridinium-4-yl)ethane diperchlorate, C12H14N2·2ClO4 – a second polymorph
Authors: Qiu Qi-Ming , Song Jian-Biao , Yan Li , Dong Ai-Guo , Li Chuan-Tao , Zheng Zhi-Yuan
Published: May 2022

C12H14N2·2ClO4, monoclinic, P21/c (no. 14), a = 5.3170(4) Å, b = 12.8711(8) Å, c = 11.6788(7) Å, β = 100.888(2)°, V = 784.86(9) Å3, Z = 2, R

gt
(F) = 0.0434, wR

ref
(F
2) = 0.1211, T = 298 K.
Software acad mico de control de pozos petroleros MAROGA
Authors: Jimenez Moreno Marcos Andres , Hernández Barajas José Roberto , Jiménez Hernández José del Carmen , Plazas Quiroga Juan Gabriel
Published: May 2022

El intento fallido en el control de un brote o el descontrol de un pozo petrolero trae consigo pérdidas económicas muy graves, por ejemplo, la pérdida total del mismo. Sin embargo, la posibilidad de analizar, seleccionar y aplicar las acciones y actividades correctas brinda la oportunidad de controlar su manifestación, cuyo resultado es la reducción y eliminación de la gravedad del descontrol. En el presente artículo se describe el desarrollo de una herramienta didáctica computacional, gráfica y numérica, diseñada para el adiestramiento y capacitación de las metodologías en el control de pozos petroleros de Petróleos Mexicanos-Asociación Internacional de Contratistas de Perforación (Pemex-IADC). Dicha aplicación se desarrolló con Macros de Visual Basic en el entorno de Microsoft y ha sido validada mediante una investigación exhaustiva para el diseño de su configuración y probada mediante la ejecución de ejercicios numéricos y la comparación con ejemplos de los manuales de WellCap de Pemex y de diversas compañías afiliadas.
El operón thnRDE de B. thuringiensis le brinda inmunidad a Lactococcus lactis contra thurincina H
Authors: Núñez Valle Mario Alberto , Velázquez Juárez Gilberto , Barboza Corona José Eleazar , Casados Vázquez Luz Edith
Published: May 2022

Lactococcus lactis es una bacteria ácido-láctica de gran importancia para la industria de los alimentos. Es una cepa segura, y por tanto se han diseñado sistemas para la expresión de proteínas recombinantes de interés biotecnológico. Dentro de las proteínas con importancia biotecnológica se encuentra la bacteriocina thurincina H, esta tiene muchas características favorables para ser empleada como bioconservador en alimentos. Se ha reportado que necesita al menos nueve genes para su biosíntesis, dentro de estos están los genes thnRDE que brindan inmunidad a la cepa productora nativa. El objetivo de este trabajo fue integrar estos tres genes a la cepa L. lactis para hacerla resistente a thurincina H y poder producirla en un futuro. Para lograrlo, se clonaron los marcos abiertos de lectura (ORF, por sus siglas en inglés) de los genes thnRDE en un vector para L. lactis, y se transformaron en la cepa sensible. Se logró obtener una cepa de L. lactis resistente a thurincina H que podrá ser empleada para su producción heteróloga segura.
Point Prevalence of the Biomechanical Dimension of Dysfunctional Breathing Patterns Among Competitive Athletes
Authors: Shimozawa Yuka , Kurihara Toshiyuki , Kusagawa Yuki , Hori Miyuki , Numasawa Shun , Sugiyama Takashi , Tanaka Takahiro , Suga Tadashi , Terada Ryoko S. , Isaka Tadao , Terada Masafumi
Published: May 2022

Shimozawa, Y, Kurihara, T, Kusagawa, Y, Hori, M, Numasawa, S, Sugiyama, T, Tanaka, T, Suga, T, Terada, RS, Isaka, T, and Terada, M. Point prevalence of the biomechanical dimension of dysfunctional breathing patterns among competitive athletes. J Strength Cond Res 37(2): 270–276, 2023—There is growing evidence of associations between altered biomechanical breathing patterns and numerous musculoskeletal and psychological conditions. The prevalence of dysfunctional and diaphragmatic breathing patterns is unknown among athletic populations. The purpose of this study was to examine the prevalence of dysfunctional and diaphragmatic breathing patterns among athletic populations with a clinical measure to assess the biomechanical dimension of breathing patterns. Using a cross-sectional design, 1,933 athletes across multiple sports and ages were screened from 2017 to 2020. Breathing patterns were assessed using the Hi-Lo test in the standing position. Scores of the Hi-Lo test were determined based on the presence or absence of abdominal excursion, anterior–posterior chest expansion, superior rib cage migration, and shoulder elevation. The Hi-Lo test scores were used to categorize observational breathing mechanics as dysfunctional and diaphragmatic breathing patterns. The prevalence of athletes with dysfunctional breathing patterns was 90.6% (1,751 of 1,933). Athletes with diaphragmatic breathing patterns accounted for 9.4% of all athletes in our sample (182 of 1,933). There were no differences in the proportion of breathing patterns between male and female athletes (p = 0.424). Breathing patterns observations were associated with sport-setting categories (p = 0.002). The highest percentages of dysfunctional breathers were in middle school student athletes (93.7%), followed by elementary school student athletes (91.2%), high school student athletes (90.6%), professional/semiprofessional athletes (87.5%), and collegiate athletes (84.8%). The current study observed that dysfunctional breathing patterns (90.6%) in the biomechanical dimension were more prevalent than diaphragmatic breathing pattern (9.4%) among competitive athletes. These results suggest that clinicians may need to consider screening breathing patterns and implementing intervention programs aimed to improve the efficiency of biomechanical dimensions of breathing patterns in athletic populations. This study may help raise awareness of impacts of dysfunctional breathing patterns on athletes' health and performance.
Sport Differences in Fat-Free Mass Index Among a Diverse Sample of NCAA Division III Collegiate Athletes
Authors: Brandner Caleb F. , Harty Patrick S. , Luedke Joel A. , Erickson Jacob L. , Jagim Andrew R.
Published: May 2022

Brandner, CF, Harty, PS, Luedke, JA, Erickson, JL, and Jagim, AR. Sport differences in fat-free mass index among a diverse sample of NCAA Division III collegiate athletes. J Strength Cond Res 36(8): 2212–2217, 2022—Fat-free mass index (FFMI) is becoming a popular metric to determine an athlete's potential for future fat-free mass accrual or to identify athletes who may be at risk for low fat-free mass (FFM). The aim of the current study was to examine sport-specific differences in FFMI among a cohort of collegiate athletes. NCAA Division III male (n = 98; age: 20.1 ± 1.6 years, height: 1.82 ± 0.06 m, body mass: 92.7 ± 17.5 kg, %BF: 15.6 ± 8.8%) and female (n = 92; age: 19.45 ± 1.1 years, height: 1.68 ± 0.06 m, body mass: 65.16 ± 11.04 kg, %BF: 22.71 ± 5.9%) athletes completed a body composition assessment using air displacement plethysmography. Fat-free mass index was calculated by dividing FFM by height squared. The mean ± SD FFMI was significantly higher (p < 0.05) for males (23.37 ± 2.41 kg·m−2) compared with females (17.54 ± 1.8 kg·m−2). There was a significant main effect for sport category. Post hoc analysis indicated that throwers had a higher (p < 0.001) FFMI (mean difference, 95% confidence interval) compared with sprinters and soccer athletes (4.17, 2.03–6.32 kg·m−2), endurance and weight-sensitive athletes (4.91, 2.67–7.14 kg·m−2), and court sport athletes (4.39, 1.97–6.81 kg·m−2), respectively, among female athletes. Post hoc analysis indicated that football players had a higher (p < 0.01) FFMI than distance runners (3.89, 2.15, 5.62) and wrestlers (2.23, 0.78, 3.68), among male athletes. These findings indicate that sex differences in FFMI exist, with differences identified between sports. These findings can guide strength and nutritional programming decisions by providing sport-specific normative data profiles.
New lathyrane diterpenoid hybrids have anti-inflammatory activity through the NF-κB signaling pathway and autophagy
Authors: Wang Wang , Xiong Liangliang , Wu Yanli , Zhou Yirong , Li Yutong , Zheng Mengzhu , Song Zhuorui , Sun Dejuan , Chen Lixia
Published: May 2022

In our ongoing work on the identification of potent anti-inflammatory agents, we designed and synthesized three series of lathyrane diterpenoid hybrids in which the lathyrane diterpenoid skeleton was hybridized with other anti-inflammatory pharmacophores. Unexpectedly, lathyrane diterpenoid/3-hydroxyflavone hybrids showed more potent anti-inflammatory activity in RAW264.7 cells than did the corresponding parent compounds. Compound 8d1 exhibited potent anti-inflammatory activity with low cytotoxicity (IC50 = 1.55 ± 0.68 μM), and downregulated LPS-induced expression of iNOS and COX-2, as well as IκBα phosphorylation. This compound also inhibited the expression and nuclear translocation of NF-κB, and stimulated autophagy induction. Thus, 8d1’s anti-inflammatory mechanism is associated with inhibition of the NF-κB signaling pathway and increasing autophagy. This compound may serve as a promising anti-inflammatory agent.
Usefulness of thyroid function assessment in infants born to mothers with thyroid dysfunction during pregnancy
Authors: Ben-Zeev Zohar Steinberg , Peniakov Marina , Felszer Clari , Weiner Scott A , Lahad Avishay , Almashanu Shlomo , Tenenbaum Rakover Yardena
Published: May 2022

Introduction

Maternal thyroid disease is considered as a risk factor for abnormal thyroid function at birth, as well as for long-term morbidity in offspring. The potential harmful effects on the neonate had led to the clinical practice of thyroid function assessment in infants born to mothers with thyroid disease during pregnancy. In this study, we evaluated the usefulness of routine thyroid function tests for every newborn of a mother with thyroid dysfunction.

Methods

Data were collected retrospectively from the medical files of mothers diagnosed with thyroid disease and their infants (496 mother–neonate pairs). All mothers with diagnosed thyroid disease who gave birth in the years 2016–2019 at our medical center were included.

Results

Hypothyroidism was the most common maternal diagnosis (91.4%), among which 48.7% had Hashimoto’s thyroiditis. Hyperthyroidism was diagnosed in 8.6% of the cohort – 71.6% of them with Graves’ disease. None of the newborns was diagnosed with congenital hypothyroidism in the screening program. Thyroid-stimulating hormone was >10 mIU/L in 14.6% and >20 mUI/L in 2.2%; all had free thyroxine within normal range. Serum thyroid function test identified four infants with thyroid disease; two had congenital hypothyroidism not related to maternal thyroid disease, one had transient familial congenital hypothyroidism and one had neonatal Graves’ disease.

Conclusions

Thyroid function testing for all newborns of mothers with thyroid dysfunction seems redundant. However, in cases of congenital hypothyroidism in siblings, thyroid function test, in addition to newborn thyroid screening, is recommended, and more careful follow-up is indicated. In maternal Graves’ disease, thyroid function test on days 2–3 of life is recommended.
Frecuencia de periodontitis apical en dientes con tratamiento endodóntico mediante tomografía computarizada volumétrica en una subpoblación de Colombia
Authors: Mesa Herrera Uriel , Blanco Fuentes Bibiana Yorley , Moreno Monsalve Jaime Omar
Published: May 2022

Introducción: La interpretación radiográfica es un componente altamente subjetivo pero esencial para el diagnóstico de la periodontitis apical, las radiografías periapicales podrían subestimar su identificación cuando las lesiones son pequeñas, lo que podría generar falsos negativos. Por otra parte, la tomografía computarizada volumétrica tiene mayor sensibilidad para identificar y medir lesiones periapicales sutiles.

Objetivo: Determinar la frecuencia de periodontitis apical utilizando imágenes de tomografía computarizada de haz cónico en una subpoblación colombiana.

Métodos: Un total de 318 dientes y raíces  con tratamientos endodónticos adecuados fueron incluidos en este estudio y evaluados mediante tomografía computarizada de haz cónico con voxel de 0,2 mm. La zona más amplia de radiolucidez apical en cada raíz dental fue medida y se le asigno un puntaje con base en el índice de radiolucidez endodóntica; la evaluación fue realizada por dos endodoncistas y un radiólogo. Frecuencias y porcentajes fueron utilizados para el análisis estadístico.

Resultados: El 60,37% de los dientes y  raíces se calificaron sanas, mientras que el 39,63% de las raíces restantes presentaron periodontitis apical.

Conclusión: La frecuencia de PA en los dientes y raíces estudiadas y que mostraron tratamiento endodontico adecuado fue del 39,63% y el tamaño de las lesiones periapicales varío entre >0,5 y 2,5 mm.
Attention Mechanisms Evaluated on Stenosis Detection using X-ray Angiography Images
Authors: Ovalle-Magallanes Emmanuel , Alvarado-Carrillo Dora E. , Avina-Cervantes Juan Gabriel , Cruz-Aceves Ivan , Ruiz-Pinales Jose , Contreras-Hernandez Jose Luis
Published: May 2022

Coronary stenosis results from unnatural narrowing of the heart arteries due to the accumulation of adipose depots, leading to different heart diseases and yielding top mortality worldwide. Thus far, deep learning-based methods for automatic stenosis over X-ray Coronary Angiography (XCA) have employed state-of-the-art architectures to solve the ImageNet challenge. With the advance of deep learning, contemporary architectures incorporated a variety of attention mechanisms to improve performance. Therefore, this paper presents a study of three attention mechanisms for stenosis detection in XCA images. Extensive experiments and comparisons over different Residual backbone networks are presented to verify the effectiveness of including such attention modules. An improvement of 4%, 10%, and 10% on the accuracy, recall, and F1-score was achieved using the approach, reaching mean values of 0.8787, 0.8610, and 0.8732, respectively.
Kurčiųjų ir neprigirdinčių studentų įsitraukimo į universitetines studijas galimybės: Jungtinės Karalystės patirtis
Authors: Ungeitytė Indrė , Ališauskienė Stefanija
Published: May 2022

Šis tyrimas atliktas Jungtinės Karalystės universitetuose. Apklausta 10 respondentų iš 3 skirtingų universitetų, veikiančių Londone. Tyrimo tikslas – atskleisti kurčiųjų ir neprigirdinčiųjų studentų įsitraukimo į universitetines studijas galimybes. Pagrindiniai tyrimo uždaviniai: išanalizuoti universitetinio mokslo prieinamumą kurtiesiems ir neprigirdintiems studentams; išsiaiškinti, ar yra prieinamos būtinos priemonės ir įranga, reikalinga pilnaverčiam studentų įtraukimui ir įsitraukimui, bei, kaip tenkinami studijų poreikiai, atsiradę dėl klausos praradimo; atskleisti, kaip studijų programa yra pritaikoma tenkinti papildomus tokių studentų mokymosi poreikius. Dalyvių imtį sudarė universiteto papildomos mokymosi pagalbos personalas ir dėstytojai. 

Tyrimas atliktas, taikant kokybinio tyrimo prieigą. Duomenys rinkti pasitelkus internetinį klausimyną, kuriame pateikti atsakymų pasirinkimai bei galimybė pateikti savo komentarus. Duomenys analizuoti, taikant teminę analizę.

Pagrindinė tyrimo išvada: kurtieji ir neprigirdintieji studentai studijuodami dažnai susiduria su sunkumais, kadangi universitetai nėra visiškai prieinami šiems besimokantiesiems dėl išteklių ir kitų reikalingų mokymosi priemonių bei įrangos trūkumo. Dėstytojams reikia daugiau mokymų ir paramos, kad jie galėtų suteikti reikiamą papildomą pagalbą pažeidžiamiems studentams. Studijų programa išlieka ta pati visiems studentams, tačiau kartais daromos išimtys studentams, turintiems papildomų poreikių. Paprastai kurtiesiems ir neprigirdintiems studentams gali būti skiriama daugiau laiko atlikti užduotis.
Про оцінювання масштабів і наслідків вимушених зовнішніх міграцій населення України
Authors: Лібанова Елла Марленівна
Published: May 2022

У доповіді наведено оцінку масштабів та наслідків вимушених зовнішніх міграцій населення України внаслідок воєнної агресії з боку Російської Федерації. Зазначено, що питання повоєнного повернення наших співгромадян з-за кордону стає чи не найважливішим у контексті збереження української нації. Окреслено першочергові завдання, які стоять перед академічною наукою, щодо вирішення проблеми безпрецедентної зовнішньої міграції і запобігання її масовому перетворенню на незворотну.
Особливості роботи Об’єднаної енергетичної системи України в синхронному режимі з європейською континентальною енергетичною системою
Authors: Кириленко Олександр Васильович
Published: May 2022

У доповіді зазначено. що в процесі підготовки Об’єднаної енергетичної системи України до переходу на синхронну роботу з об’єднанням енергосистем європейських країн постала ціла низка науково-технічних завдань, у вирішенні яких активну участь брали профільні установи НАН України. Ці роботи виконувалися в рамках серії цільових програм наукових досліджень НАН України «Об’єднання». Отримані результати дали змогу в складних умовах успішно реалізувати перехід ОЕС України на режим повної синхронізації з європейською енергетичною мережею ENTSO-E і відокремлення від енергетичних систем Росії та Білорусі.
An Anthropology of Exploitation Techniques in the London Real Estate and Labor Market
Authors: Szőke Noémi
Published: May 2022

This study explores the life-mode of Hungarian migrants in their destination country, England, particularly London in the last decade, focusing on their housing conditions and working experiences. Relying on her participant observations and interviews, the author formulates a picture through the eyes of Hungarian migrant laborers regarding how both the real estate and labor market exploits them (micro level). She explains the motives of the main economic actors (entrepreneurs, real estate and employment agencies, employers) leading to exploitations (meso level) in addition to discussing how all of these fit into the wider socio-economic context (macro level).
Rethinking Chronology and Narrative Modes: The Case of Sancī Stūpa 2
Authors: Zaghet Flavia
Published: May 2022

Different modes of visual narration were employed in early Buddhist art. As a result, visualizations of the same narrative are often both profoundly different and difficult to interpret (or even identify) in the absence of inscriptions or securely identified comparisons. The aim of this chapter is to illustrate the benefits of a reconsideration on the one hand of established chronologies (which have considerably influenced the history of iconographic studies) and on the other of visual narration modes in order to deepen our knowledge of the visual expressions of narrative in early Buddhist art. The case of Sanchi Stūpa 2 provides a prime example, where a chronological reassessment and the identification of a variant of the monoscenic mode of visual narration (the spotlight mode) lead to the identification of a narrative vein including (as yet) unknown narratives. The same kind of approach could be fruitfully applied to well-studied reliefs as well as more obscure ones, hopefully paving the way for the development of studies in the future.
Empreendedorismo acadêmico e a nova morfologia social do trabalho: estudo de caso das empresas juniores da Universidade Estadual Paulista (UNESP)
Authors: Ribeiro Bruno Chapadeiro
Published: May 2022

Sabe-se que o século XX moldou-se pela estruturação da chamada sociedade do trabalho, em que desde muito cedo fomos educados para o princípio fundante do trabalho. Nos EUA, o Babson College torna-se um pólo de propagação do conceito de empreendedorismo com enfoque no ensino desta na graduação e pós-graduação, com base na valorização da “oportunidade” e da “superação de obstáculos”, introduzindo a educação para o trabalho empresarial através do currículo e das atividades extracurriculares. Em 1967, em Paris, estudantes da ESSEC Business School, com necessidades de experiências práticas que complementassem a formação acadêmica obtida na graduação, fundam uma associação sem fins lucrativos denominada Junior-Enterprise, com o objetivo de complementar a formação teórica adquirida na universidade através da aplicação prática encontrada na dita realidade empresarial. Em 1988, por iniciativa da Câmara de Comércio Brasil-França o conceito de empresa júnior chega ao Brasil. O Projeto Empresas Juniores surge na Universidade Estadual Paulista (UNESP) em 1992 e hoje contam com recursos para desenvolver seus projetos advindos de investimentos públicos e privados reproduzindo uma educação voltada para a lógica capitalista-mercantil, que impulsiona seus estudantes para o chamado mundo dos pequenos negócios.
National Ambulatory Medical Care Survey–Community Health Centers: 2020 National Summary Tables
Authors: Santo Loredana , Okeyode, Titilayo , Schappert Susan
Published: May 2022

The Ambulatory and Hospital Care Statistics Branch is pleased to release nationally representative estimates of ambulatory care visits made to both physicians and nonphysician clinicians (physician assistants [PAs], nurse practitioners [NPs], and nurse midwives) at community health centers (CHCs) in the United States. These web tables provide national estimates of visits to CHC providers and their characteristics.
Editorial
Authors:   Polish Political Science Association (Poland), Żukowski Arkadiusz
Published: May 2022

Dear Readers, I am very pleased to present you the 45th volume of the Polish Political Science Yearbook (2016). From the beginning, the journal was connected with the Polish Association of Political Science (established in 1957) and in fact, played a role in its organ. At first, the periodical was published under the title Polish Round Table, and then the name was changed into the current one. The fundamental aims of the Polish Political Science Yearbook for the last 45 years and even earlier have not changed. The authors have made an effort to maintain and even increase the quality of publishing papers. These aims were and are the priority tasks. In the near future the deepened emphasis will be directed towards theoretical and methodological background of every paper. The PPSY will be more open for scientific discourse on various vital challenges and threats of contemporary political science in Poland and in the World.
Servant Leadership and Life Satisfaction at Public School in Indonesia: Career Satisfaction as Mediator
Authors: Dami Zummy Anselmus , Imron Ali , Burhanuddin Burhanuddin , Supriyanto Achmad , Mustiningsih Mustiningsih
Published: May 2022

The research aimed to test servant leadership role in improving life satisfaction through career satisfaction. The method used was quantitative with structural equation modeling. The results showed that servant leadership has a positive and significant effect on career and life satisfaction, career satisfaction has a positive and significant influence on life satisfaction, and career satisfaction was a complementary mediator between servant leadership and teacher life satisfaction.