bluuebunny/crossref_metadata_2025 huggingface dataset:
Self-Awareness of Sleep Apnea Symptoms Among Middle-Aged and Elderly People in Taiwan
Authors: Hsueh Meng-Lun , Jong Din
Published: July 2022

In recent years, the proportion of middle-aged and elderly people in Taiwan has gradually increased and has already surpassed that of advanced countries such as Europe, the United States and Japan, therefore, the health of middle-aged and elderly people is a topic that needs attention. This is because physical deterioration or illness can lead to a decline in quality of life and create a medical burden on the individual and society. This study investigated the common symptoms of sleep apnea in middle-aged and elderly people (over 40 years old), and developed a self-test subjective perception model, using “daytime sleepiness” and “sleep quality” as influencing factors, and “attention” as mediating variables to verify the effect with sleep apnea symptoms. An online electronic questionnaire was conducted and distributed through social media and groups of friends in Taiwan. A total of 541 valid questionnaires were collected and analyzed in three stages: Descriptive Analysis, Measurement Model Validation, and Structural Equation Model. The research processes of the study showed that the sample fitted the normal distribution and the measurement model conformed with convergent reliability and discriminant validity. The research results were found that “sleep quality” had a significant negative effect on sleep apnea symptoms. “Daytime sleepiness” had a positive effect on sleep apnea symptoms. “Daytime sleepiness” had a negative effect on sleep apnea symptoms through the “attention” mediator. Finally, through the questionnaire, we hope to make the middle-aged people aware of themselves, so that they can seek early medical treatment if there are signs and symptoms of sleep apnea symptoms.
Socioeconomic disparities between oral cavity cancer patients in Germany
Authors: Muallah David , Matschke Jan , Muallah Sophie , Klimova Anna , Kroschwald Lysann Michaela , Schröder Tom Alexander , Lauer Günter , Haim Dominik
Published: July 2022

Objective

In many countries the access to high quality medical service depends on socioeconomic factors. Therefore, these factors are associated with the treatment and prognosis of many diseases. In Germany health care is claimed to be independent from such factors due to obligatory health insurance and a well-developed medical infrastructure. Thus, socioeconomically caused health disparities should be absent. The aim of this study was to analyze the association between socioeconomic factors and the survival of oral cavity cancer in Germany.

Patients and methods

In this descriptive cohort study socioeconomic status related factors as well as demographic, tumor-specific, and comorbidity factors of 500 patients treated for oral cavity cancer were obtained in the university hospital of Dresden. Pearson correlation was used to describe associations between continuous variables. Associations between categorical variables were assessed using the chi-square test. Overall and recurrence-free survival were studied using the Kaplan-Meier method. Log-rank test was carried out to test between-group differences. Cox proportional hazard models were used to estimate the risk of death and the risk of recurrence.

Results

Significant differences in overall survival were found between the different educational levels and sex. Seventy-nine percent of the patients did not have a university degree or master craftsman/craftswoman. Less discrepancy was observed according to the marital status (49.4% married/engaged vs. 47.8% single, divorced, or widowed). In the multivariable analysis only sex, age at diagnosis, the Charlson score, the number of positive lymph nodes, and the nodal status were identified as independent predictors for overall survival whereas sex and the age at diagnosis were identified as independent predictors for recurrence-free survival.

Conclusion

Despite the equitable health system in Germany, significant associations between overall survival of oral cavity cancer and different socioeconomic factors could be found. For elimination of these disparities, health education programs should be established in socially deprived areas. Furthermore, clinicians should keep these factors in mind when determining recall periods for dental check-ups.
The Negative Impact of COVID-19 in HCV, HIV, and HPV Surveillance Programs During the Different Pandemic Waves
Authors: Romero-Hernández Beatriz , Martínez-García Laura , Rodríguez-Dominguez Mario , Martínez-Sanz Javier , Vélez-Díaz-Pallarés Manuel , Pérez Mies Belen , Muriel A. , Gea Francisco , Pérez-Elías María Jesús , Galán Juan Carlos
Published: July 2022

Background

The coronavirus disease 2019 (COVID-19) pandemic has been a worldwide stress test for health systems. 2 years have elapsed since the description of the first cases of pneumonia of unknown origin. This study quantifies the impact of COVID-19 in the screening program of chronic viral infections such as human papillomavirus (HPV), human immunodeficiency virus (HIV), and hepatitis C virus (HCV) along the six different pandemic waves in our population. Each wave had particular epidemiological, biological, or clinical patterns.

Methods

We analyzed the number of samples for screening of these viruses from March 2020 to February 2022, the new infections detected in the pandemic period compared to the previous year, the time elapsed between diagnosis and linking to treatment and follow-up of patients, and the percentage of late HIV diagnosis. Moreover, we used the origin of the samples as a marker for quantifying the restoration of activity in primary care.

Results

During the first pandemic year, the number of samples received was reduced by 26.7, 22.6, and 22.5% for molecular detection of HPV or serological HCV and HIV status respectively. The highest decrease was observed during the first wave with 70, 40, and 26.7% for HPV, HCV, and HIV. As expected, new diagnoses also decreased by 35.4, 58.2, and 40.5% for HPV, HCV, and HIV respectively during the first year of the pandemic. In the second year of the pandemic, the number of samples remained below pre-pandemic period levels for HCV (−3.6%) and HIV (−9.3%) but was slightly higher for HPV (8.0%). The new diagnoses in the second year of the pandemic were −16.1, −46.8, and −18.6% for HPV, HCV, and HIV respectively.

Conclusions

Undoubtedly, an important number of new HPV, HCV, and HIV infections were lost during the COVID-19 pandemic, and surveillance programs were disrupted as a consequence of collapse of the health system. It is a priority to reinforce these surveillance programs as soon as possible in order to detect undiagnosed cases before the associated morbidity-mortality increases. New pandemic waves could increase the risk of reversing the achievements made over the last few decades.
“It's my frenemy”: A qualitative exploration of knowledge and perceptions of fentanyl use during the COVID-19 pandemic in people who use drugs at a syringe services program in Philadelphia, PA
Authors: Bass Sarah Bauerle , Kelly Patrick J. A. , Pandit-Kerr Sphoorti , Pilla Jenine , Morris Katherine , Larsen Erin , Wisdom Jennifer P. , Torralva Phillip R.
Published: July 2022

Background

Exacerbated by the COVID-19 pandemic and the proliferation of fentanyl and fentanyl analogs, overdose deaths have surged in the United States, making it important to understand how individuals who use drugs experience and perceive the risks of fentanyl use and how it has changed during the COVID-19 pandemic.

Methods

Twenty clients from a Philadelphia syringe services program completed a questionnaire and in-depth interview about their fentanyl experiences from January to March 2021. These interviews were transcribed and analyzed using thematic analysis methods.

Results

Sixty percent of participants were female and racial/ethnic minority. Participants indicated they believed fentanyl use accounted for most Philadelphia opioid-related overdoses and understood that fentanyl was different from other opioids. Fentanyl use was characterized as “all-consuming” by taking over lives and inescapable. While most perceived their risk of fentanyl overdose as high, there was low interest in and reported use of harm reduction strategies such as fentanyl test strips. The COVID-19 pandemic was noted to have negative effects on fentanyl availability, use and overdose risk, as well as mental health effects that increase drug use.

Conclusions

The divide between perceived risk and uptake of protective strategies could be driven by diminished self-efficacy as it relates to acting on and engaging with resources available at the syringe services program and represents a potential intervention target for harm reduction intervention uptake. But the COVID-19 pandemic has exacerbated risks due to fentanyl use, making an effective, accessible, and well-timed intervention important to address the disconnect between perceived overdose risk and use of preventive behaviors.
Shear wave elastography as a quantitative biomarker of diabetic peripheral neuropathy: A systematic review and meta-analysis
Authors: Dong Bingtian , Lyu Guorong , Yang Xiaocen , Wang Huaming , Chen Yongjian
Published: July 2022

Background

Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes and the strongest initiating risk factor for diabetic foot ulceration. Early diagnosis of DPN through screening measures is, therefore, of great importance for diabetic patients. Recently, shear wave elastography (SWE) has been used as a method that is complementary to neuroelectrophysiological examination in the diagnosis of DPN. We aimed to conduct a meta-analysis based on currently available data to evaluate the performance of tibial nerve stiffness on SWE for diagnosing DPN.

Methods

Both PubMed, EMBASE, the Cochrane Library, and Web of Science were searched for studies that investigated the diagnostic performance of SWE for DPN up to March 1th, 2022. Three measures of diagnostic test performance, including the summary area under receiver operating characteristics curve (AUROC), the summary sensitivity and specificity, and the summary diagnostic odds ratios were used to assess the diagnostic accuracy of SWE. All included studies were published between 2017 and 2021.

Results

Six eligible studies (with 170 DPN patients, 28 clinically defined DPN patients, 168 non-DPN patients, and 154 control participants) that evaluated tibial nerve stiffness were included for meta-analysis. The summary sensitivity and specificity of SWE for tibial nerve stiffness were 75% (95% confidence interval [CI]: 68–80%) and 86% (95% CI: 80–90%), respectively, and the summary AUROC was 0.84 (95% CI: 0.81–0.87), for diagnosing DPN. A subgroup analysis of five two-dimensional SWE studies revealed similar diagnostic performance, showing the summary sensitivity and specificity of 77% (95% CI: 69–83%) and 86% (95% CI: 79–91%), respectively, and a summary AUROC value of 0.86 (95% CI: 0.83–0.89).

Conclusions

SWE is found to have good diagnostic accuracy for detecting DPN and has considerable potential as an important and noninvasive adjunctive tool in the management of patients with DPN.
Prediction of COVID-19 Data Using Hybrid Modeling Approaches
Authors: Zhao Weiping , Sun Yunpeng , Li Ying , Guan Weimin
Published: July 2022

A major emphasis is the dissemination of COVID-19 across the country's many regions and provinces. Using the present COVID-19 pandemic as a guide, the researchers suggest a hybrid model architecture for analyzing and optimizing COVID-19 data during the complete country. The analysis of COVID-19's exploration and death rate uses an ARIMA model with susceptible-infectious-removed and susceptible-exposed-infectious-removed (SEIR) models. The logistic model's failure to forecast the number of confirmed diagnoses and the snags of the SEIR model's too many tuning parameters are both addressed by a hybrid model method. Logistic regression (LR), Autoregressive Integrated Moving Average Model (ARIMA), support vector regression (SVR), multilayer perceptron (MLP), Recurrent Neural Networks (RNN), Gate Recurrent Unit (GRU), and long short-term memory (LSTM) are utilized for the same purpose. Root mean square error, mean absolute error, and mean absolute percentage error are used to show these models. New COVID-19 cases, the number of quarantines, mortality rates, and the deployment of public self-protection measures to reduce the epidemic are all outlined in the study's findings. Government officials can use the findings to guide future illness prevention and control choices.
Epidemic characteristics and transmission risk prediction of brucellosis in Xi'an city, Northwest China
Authors: Zhao Chenxi , Liu Kun , Jiang Chenghao , Wei Xiao , Song Shuxuan , Wu Xubin , Wen Xiaohui , Fu Ting , Shen Li , Shao Zhongjun , Li Qian
Published: July 2022

Human brucellosis (HB) has re-emerged in China since the mid-1990s, and exhibited an apparent geographic expansion shifted from the traditional livestock regions to the inland areas of China. It is often neglected in non-traditional epidemic areas, posing a serious threat to public health in big cities. We carried out a retrospective epidemiological study in Xi'an, the largest city in northwestern China. It utilizes long-term surveillance data on HB during 2008–2021 and investigation data during 2014–2021. A total of 1989 HB cases were reported in Xi'an, consisting of 505 local cases, i.e., those located in Xi'an and 1,484 non-local cases, i.e., those located in other cities. Significantly epidemiological heterogeneity was observed between them, mainly owing to differences in the gender, occupation, diagnostic delays, and reporting institutions. Serological investigations suggested that 59 people and 1,822 animals (sheep, cattle, and cows) tested positive for brucellosis from 2014 to 2021, with the annual average seroprevalence rates were 1.38 and 1.54%, respectively. The annual animal seroprevalence rate was positively correlated with the annual incidence of non-local HB cases. Multivariate boosted regression tree models revealed that gross domestic product, population density, length of township roads, number of farms, and nighttime lights substantially contributed to the spatial distribution of local HB. Approximately 7.84 million people inhabited the potential infection risk zones in Xi'an. Our study highlights the reemergence of HB in non-epidemic areas and provides a baseline for large and medium-sized cities to identify regions, where prevention and control efforts should be prioritized in the future.
Pulmonary Cryptococcosis Diagnosed by Metagenomic Next-Generation Sequencing in a Young Patient With Normal Immune Function: A Case Report
Authors: Zhang Yingyu , Wang Weiliang , Zhang Yingxuan , Zhai Sina , Xia Han , Zhang Xilin
Published: July 2022

Background

Pulmonary cryptococcosis (PC) is a serious opportunistic fungal infection that usually occurs in immunocompromised patients. This disease is often difficult to diagnose in time due to its clinical manifestations and radiological feature similar to other pulmonary infections, as well as the low sensitivity of conventional diagnostic methods. Cryptococcosis in immune-competent patients is rare.

Case Presentation

Here we report a case of PC in an immune-competent patient. Tuberculosis was suspected according to radiological features due to the positive T-lymphocyte spot test and pure protein derivative skin test. To further detect the pathogen, bronchoalveolar lavage fluid (BALF) was collected for metagenomic next-generation sequencing (mNGS). Cryptococcus neoformans (one specific read) was identified by mNGS, indicating the PC of this patient. The following BALF culture and cryptococcal antigen lateral flow assay (CrAg-LFA) test also showed Cryptococcus infection, confirming the mNGS detection. Voriconazole (0.4 g daily) was given orally according to the subsequent susceptibility results. After seven months of treatment, the patient's condition improved.

Conclusion

Metagenomic next-generation sequencing (mNGS) is a better diagnostic tool to help clinicians distinguish pulmonary cryptococcosis from other atypical pulmonary infections.
Pursuing Quality Education in Physical and Rehabilitation Medicine in Japan
Authors: Asami Toyoko
Published: July 2022

In Japan, medical education and training are the combined responsibility of two ministries namely Ministry of Education, Culture, Sports, Science and Technology, and the Ministry of Health, Labor and Welfare. The medical education system underwent a major transformation in August 2021 making it a seamless clinical education blending pre-graduation and post-graduation training. Not all universities offer rehabilitation medicine curriculum. Furthermore, where rehabilitation medicine is taught, the curriculum content is not standardized. All medical students sit for a common national medical practitioner qualifying examination. However, only a few questions on Rehabilitation Medicine are included. The personal experience of the author's teachings in rehabilitation medicine at Saga University medical school is described. Emphasis is placed on experiential learning on subjects that are current and state-of-the-art in Japan including robotics. It is aimed at promoting inspired motivation for the students to pursue specialized training in rehabilitation medicine. Japan can take lessons from the European Union's white book on Physical Medicine and Rehabilitation as well as the International Society of Physical and Rehabilitation Medicine core curriculum. In addition, the Rehabilitation Medicine education system can be further improved through a well-coordinated preclinical and clinical medical education. There is also a need to expand the rehabilitation medicine field and address the gaps with other specialties.
Changes in social participation between 1 and 2 years following moderate-severe traumatic brain injury
Authors: Hart Tessa , Rabinowitz Amanda
Published: July 2022

Objective

To examine patterns of change in social participation in persons with moderate-severe traumatic brain injury (msTBI) between 1 and 2 years postinjury, and predictors of observed change.

Participants

375 participants with msTBI enrolled in a single TBI Model System site.

Measures and Methods

The dependent variable in a linear regression was a reliable change score for the Social Relations subscale of the Participation Assessment with Recombined Tools-Objective, administered at 1- and 2-year follow-ups. Predictors of change included demographics, injury severity, social and functional status at Year 1, and changes in function and life circumstances between years 1 and 2.

Results

Social participation status did not change substantially for 34 of the sample, while approximately equal proportions of the remainder improved or declined. The regression model was significant (p < 0.001). Improvement was predicted by private vs. public insurance and decline was predicted by a reduction in the FIM functional outcome measure from year 1 to year 2. Marginal predictors included education (higher levels predicting improvement) and year 1 marital status (single status predicting decline).

Conclusions

Longitudinal change in social participation in the chronic phase of msTBI deserves further study, with attention to resource limitations and the impact of changes in functional status.
Expanding the reach of evidence-based mental health interventions to private practice: Qualitative assessment using a policy ecology framework
Authors: Frank Hannah E. , Milgram Lauren , Freeman Jennifer B. , Benito Kristen G.
Published: July 2022

Background

Evidence-based interventions (EBIs) for mental health disorders are underutilized in routine clinical practice. Exposure therapy for anxiety disorders is one particularly difficult-to-implement EBI that has robust empirical support. Previous research has examined EBI implementation determinants in publicly funded mental health settings, but few studies have examined EBI implementation determinants in private practice settings. Private practice clinicians likely face unique barriers to implementation, including setting-specific contextual barriers to EBI use. The policy ecology framework considers broad systemic determinants, including organizational, regulatory, social, and political contexts, which are likely relevant to EBI implementation in private practice settings but have not been examined in prior research.

Methods

Qualitative interviews were conducted to assess private practice clinicians' perceptions of EBI implementation determinants using the policy ecology framework. Clinicians were asked about implementing mental health EBIs broadly and exposure therapy specifically. Mixed methods analyses compared responses from clinicians working in solo vs. group private practice and clinicians who reported high vs. low organizational support for exposure therapy.

Results

Responses highlight several barriers and facilitators to EBI implementation in private practice. Examples include determinants related to organizational support (e.g., colleagues using EBIs), payer restrictions (e.g., lack of reimbursement for longer sessions), fiscal incentives (e.g., payment for attending training), and consumer demand for EBIs. There were notable differences in barriers faced by clinicians who work in group private practices compared to those working in solo practices. Solo private practice clinicians described ways in which their practice setting limits their degree of colleague support (e.g., for consultation or exposure therapy planning), while also allowing for flexibility (e.g., in their schedules and practice location) that may not be available to clinicians in group practice.

Conclusions

Using the policy ecology framework provides a broad understanding of contextual factors that impact private practice clinicians' use of EBIs, including exposure therapy. Findings point to potential implementation strategies that may address barriers that are unique to clinicians working in private practice.
Control of a Wheelchair-Mounted 6DOF Assistive Robot With Chin and Finger Joysticks
Authors: Rulik Ivan , Sunny Md Samiul Haque , Sanjuan De Caro Javier Dario , Zarif Md Ishrak Islam , Brahmi Brahim , Ahamed Sheikh Iqbal , Schultz Katie , Wang Inga , Leheng Tony , Longxiang Jason Peng , Rahman Mohammad H.
Published: July 2022

Throughout the last decade, many assistive robots for people with disabilities have been developed; however, researchers have not fully utilized these robotic technologies to entirely create independent living conditions for people with disabilities, particularly in relation to activities of daily living (ADLs). An assistive system can help satisfy the demands of regular ADLs for people with disabilities. With an increasing shortage of caregivers and a growing number of individuals with impairments and the elderly, assistive robots can help meet future healthcare demands. One of the critical aspects of designing these assistive devices is to improve functional independence while providing an excellent human–machine interface. People with limited upper limb function due to stroke, spinal cord injury, cerebral palsy, amyotrophic lateral sclerosis, and other conditions find the controls of assistive devices such as power wheelchairs difficult to use. Thus, the objective of this research was to design a multimodal control method for robotic self-assistance that could assist individuals with disabilities in performing self-care tasks on a daily basis. In this research, a control framework for two interchangeable operating modes with a finger joystick and a chin joystick is developed where joysticks seamlessly control a wheelchair and a wheelchair-mounted robotic arm. Custom circuitry was developed to complete the control architecture. A user study was conducted to test the robotic system. Ten healthy individuals agreed to perform three tasks using both (chin and finger) joysticks for a total of six tasks with 10 repetitions each. The control method has been tested rigorously, maneuvering the robot at different velocities and under varying payload (1–3.5 lb) conditions. The absolute position accuracy was experimentally found to be approximately 5 mm. The round-trip delay we observed between the commands while controlling the xArm was 4 ms. Tests performed showed that the proposed control system allowed individuals to perform some ADLs such as picking up and placing items with a completion time of less than 1 min for each task and 100% success.
Outer membrane vesicles of the oral pathogen Porphyromonas gingivalis promote aggregation and phagocytosis of Staphylococcus aureus
Authors: du Teil Espina Marines , Haider Rubio Anna , Fu Yanyan , López-Álvarez Marina , Gabarrini Giorgio , van Dijl Jan Maarten
Published: July 2022

Staphylococcus aureus is an opportunistic Gram-positive bacterial pathogen that causes a wide variety of infectious diseases, including S. aureus bacteremia (SAB). Recent studies showed that rheumatoid arthritis (RA) is a risk factor for SAB, as RA patients appear to be more susceptible to SAB and display higher degrees of disease severity or complications, such as osteoarticular infections. On the other hand, Porphyromonas gingivalis is a Gram-negative bacterial oral pathogen, which is notable for its implication in the etiopathogenesis of RA due to its unique citrullinating enzyme PPAD and its highly effective proteases, known as gingipains. Both PPAD and gingipains are abundant in P. gingivalis outer membrane vesicles (OMVs), which are secreted nanostructures that originate from the outer membrane. Here we show that P. gingivalis OMVs cause the aggregation of S. aureus bacteria in a gingipain- and PPAD-dependent fashion, and that this aggregation phenotype is reversible. Importantly, we also show that the exposure of S. aureus to OMVs of P. gingivalis promotes the staphylococcal internalization by human neutrophils with no detectable neutrophil killing. Altogether, our observations suggest that P. gingivalis can eliminate its potential competitor S. aureus by promoting staphylococcal aggregation and the subsequent internalization by neutrophils. We hypothesize that this phenomenon may have repercussions for the host, since immune cells with internalized bacteria may facilitate bacterial translocation to the blood stream, which could potentially contribute to the association between RA and SAB.
The impact of a group based, remotely delivered weight loss intervention in women with polycystic ovary syndrome on ovulation, quality of life and body composition
Authors: Gorczyca Anna M. , Steger Felicia L. , Ptomey Lauren T. , Montgomery Robert N. , Mickelsen Riley , Smith Patricia , Donnelly Joseph E. , Marsh Courtney A.
Published: July 2022

Background

Obesity and visceral adiposity are associated with anovulation. The most common cause of anovulatory infertility in women of reproductive age is polycystic ovary syndrome (PCOS). We conducted this formative study to examine the effects of a remotely delivered, group-based lifestyle program for women with overweight/obesity and PCOS on ovulation, PCOS related quality of life (PCOSQ) and body composition.

Methods

Women with anovulatory infertility caused by PCOS (N = 12) were enrolled in a 6-month high-intensity weight management intervention. Participants were asked to attend 45 min., group behavioral lifestyle sessions, delivered remotely by a registered dietitian weekly across the 6-mo. study and comply with a reduced energy diet, increased physical activity (225 min/wk.), and self-monitoring of weight, physical activity and diet. Diets consisted of five portion-controlled meals (three shakes + two entrees), at least five servings of fruits/vegetables, and ad libitum non-caloric beverages daily. Wilcoxon signed-rank tests were used to assess changes in outcomes across the intervention.

Results

Twelve women received the weight loss intervention (mean age = 32.7 ± 4.2 yrs., BMI = 36.8 ± 4.5 kg/m2, 92% college educated), and 8 completed the intervention. Eight (67%) women reported ovulating during the intervention with an average time to ovulation of 57 ± 45 days. Women lost an average of 3.85 ± 5.94 kg (p = 0.02), decreased their BMI (−1.61 ± 1.09 kg/m2; p = 0.04), and waist circumference (−4.54 ± 3.03 cm; p = 0.04) over the 6-mo. intervention. Additionally, self-reported menstrual problems measured by PCOSQ significantly improved over the study (p = 0.03).

Conclusion

A multicomponent group-based, remotely delivered, lifestyle intervention delivered remotely is a feasible and potentially scalable option to achieve clinically relevant (>3%) weight loss in women with PCOS.

Clinical trial registration

www.clinicaltrials.gov, identifier: NCT03677362.
Local Action Groups and Sustainable Development Agenda: Case Study of Regional Perspectives From Czechia
Authors: Vávra Jan , Dlouhá Jana , Pospíšilová Marie , Pělucha Martin , Šindelářová Iveta , Dvořáková Líšková Zuzana , Hartych Marek , Dlouhý Jiří , Cudlínová Eva
Published: July 2022

The United Nations' 2030 Agenda for Sustainable Development is generally accepted as an overarching framework to cope with various global challenges. Many of them are manifested locally and need to be solved at the regional or local level. National strategies of regional development and top-down funding are important drivers of the activities of various regional actors. However, the integration of the regional development strategies and the sustainable development agenda is not straightforward and may fail to acknowledge the local context and potential for bottom-up activities. In the European Union's (EU) context, the local action groups (LAGs) are an important driving force of regional development, but little is known about their perception of the sustainable development agenda. The article presents a research case study of Czech LAGs realized in 2021. LAGs were approached with questionnaires focusing on their understanding of the sustainable development agenda and their own role in the process of its implementation. In this paper, we show that the LAGs' representatives are aware of the sustainable development concept and work with relevant governmental strategies, but they feel that they cannot contribute to the fulfillment of many particular sustainable development goals (SDGs), especially those related to the environment. This contrasts with their reflection of the goals with an economic and social focus in which they feel relatively more empowered, especially in education. Our findings reveal that there is a high risk of mismatch between the bottom-up potential of LAGs for regional sustainable development and top-down conditions of national strategies. The results of the research contribute to the contemporary discussions about the SDGs and regional development and thus could be used by both academics and practitioners. Notably, national policymakers and regional authorities could benefit from our insights into LAGs' perspective of SDGs' implementation.
Migrant families' access to ECEC and family policies: The Australian and Italian case compared
Authors: Naldini Manuela , Adamson Elizabeth , Hamilton Myra
Published: July 2022

This paper analyses in a comparative perspective the degree of convergence in migrant families' access to early childhood education and care (ECEC) and work/family policies in two different welfare state regimes: Italy and in Australia. Using a framework based on the concept of conditionality—or the notion that access to support is conditional and based on an individual's personal and familial characteristics, circumstances or behaviors—-the analysis examines the extent to which policies designed to support families with young children are accessible to migrant families. It argues that access to ECEC and family policies is restricted in both Italy and Australia according to a series of conditions, but that these conditions apply differently to people of different migrant statuses. In doing so the paper aims to improve our understanding of how welfare states respond to needs associated with migration for children and families and the extent to which they tend to converge.
Validity and Reliability of a Commercial Force Sensor for the Measurement of Upper Body Strength in Sport Climbing
Authors: Labott Berit K. , Held Steffen , Wiedenmann Tim , Rappelt Ludwig , Wicker Pamela , Donath Lars
Published: July 2022

Recreational and professional climbing is gaining popularity. Thus, valid and reliable infield strength monitoring and testing devices are required. This study aims at assessing the validity as well as within- and between-day reliability of two climbing-specific hanging positions for assessing the maximum force with a new force measurement device. Therefore, 25 experienced male (n = 16) and female (n = 9) climbers (age: 25.5 ± 4.2 years, height: 176.0 ± 9.9 cm, weight: 69.7 ± 14.5 kg, body composition: 11.8 ± 5.7% body fat, climbing level: 17.5 ± 3.9 International Rock Climbing Research Association scale) were randomly tested with climbing-specific hang board strength tests (one-handed rung pulling and one-handed bent arm lock-off at 90°). The Tindeq, a load cell-based sensor for assessing different force-related variables, was employed together with a force plate (Kistler Quattro Jump) during both conditions. Data analysis revealed excellent validity for assessment with Tindeq: The intra-class correlation coefficient (ICC) was 0.99 (both positions), while the standard error of the measurement (SEM), coefficient of variation (CV), and limits of agreement (LoA) showed low values. Within day reliability for the assessment with Tindeq was excellent: rung pulling showed an ICC of 0.90 and arm lock-off an ICC of 0.98; between-day reliability was excellent as well: rung pulling indicated an ICC of 0.95 and arm lock-off an ICC of 0.98. Other reliability indicators such as SEM, CV, and LoA were low. The Tindeq progressor can be applied for the cross-sectional and longitudinal climbing strength assessment as this device can detect training-induced changes reliably.
What are the kinematic characteristics of the world champion couple in competitive ballroom dance during the waltz's spin movement?
Authors: Yoshida Yasuyuki , Bizokas Arunas , Demidova Katusha , Nakai Shinichi , Nakai Rie , Nishimura Takuichi
Published: July 2022

To evaluate competitive ballroom dancing, one of the official events of the World Games, spin movements used by advanced dancers who ranked high in actual competition may be employed. The purpose of this study was to investigate the kinematic characteristics of spin movements in competitive ballroom dancing performed by world champion couples, especially holding posture and lower limb movements. A champion couple and 13 national-level competitive ballroom dancers as the control group participated in this study. An inertial measurement unit (IMU) system (MVN Link; Xsens, Netherlands) consisting of 17 IMUs, attached to feet, shanks, thighs, pelvis, sternum, head, upper arms, forearms, and hands of the dancers, was used to obtain three-dimensional kinematic data at 240 Hz. The overall trend was that the actual and normalized stride lengths of the champion male and female dancers tended to be longer than those of the male and female dancers in the control group. Further, large differences were observed in the pelvic and rib cage segments movements, and the relative angle of the rib cage segment to the pelvic segment. The champion male dancer started to move from the pelvic segment, whereas the champion female dancer and the national-level top male and female dancers started to move from the rib cage segment. During the spin movement, the champion male dancer was in a position where the rib cage segment was rotated to the left with respect to the pelvic segment, whereas the other dancers were in a position where the rib cage segment was rotated to the right. Although limited to technical aspects, these dance kinematic characteristics of the world champion couples and their differences from those of the control group dancers, will be helpful to competitive ballroom dancers and coaches in their daily practice.
Rice Management Decisions Using Process-Based Models With Climate-Smart Indicators
Authors: Arenas-Calle Laura N. , Heinemann Alexandre B. , Soler da Silva Mellissa A. , dos Santos Alberto Baeta , Ramirez-Villegas Julian , Whitfield Stephen , Challinor Andrew J.
Published: July 2022

Irrigation strategies are keys to fostering sustainable and climate-resilient rice production by increasing efficiency, building resilience and reducing Greenhouse Gas (GHG) emissions. These strategies are aligned with the Climate-Smart Agriculture (CSA) principles, which aim to maximize productivity whilst adapting to and mitigating climate change. Achieve such mitigation, adaptation, and productivity goals- to the extent possible- is described as climate smartness. Measuring climate smartness is challenging, with recent progress focusing on the use of agronomic indicators in a limited range of contexts. One way to broaden the ability to measure climate-smartness is to use modeling tools, expanding the scope of climate smartness assessments. Accordingly, and as a proof-of-concept, this study uses modeling tools with CSA indicators (i.e., Greenhouse Intensity and Water Productivity) to quantify the climate-smartness of irrigation management in rice and to assess sensitivity to climate. We focus on a field experiment that assessed four irrigation strategies in tropical conditions, Continuous Flooding (CF), Intermittent Irrigation (II), Intermittent Irrigation until Flowering (IIF), and Continuous soil saturation (CSS). The DNDC model was used to simulate rice yields, GHG emissions and water inputs. We used model outputs to calculate a previously developed Climate-Smartness Index (CSI) based on water productivity and greenhouse gas intensity, which score on a scale between−1 (lack of climate-smartness) to 1 (high climate smartness) the climate-smartness of irrigation strategies. The CSS exhibited the highest simulation-based CSI, and CF showed the lowest. A sensitivity analysis served to explore the impacts of climate on CSI. While higher temperatures reduced CSI, rainfall mostly showed no signal. The climate smartness decreasing in warmer temperatures was associated with increased GHG emissions and, to some extent, a reduction in Water Productivity (WP). Overall, CSI varied with the climate-management interaction, demonstrating that climate variability can influence the performance of CSA practices. We conclude that combining models with climate-smart indicators can broaden the CSA-based evidence and provide reproducible research findings. The methodological approach used in this study can be useful to fill gaps in observational evidence of climate-smartness and project the impact of future climates in regions where calibrated crop models perform well.
Assessment of a novel smartglass-based point-of-care fusion approach for mixed reality-assisted targeted prostate biopsy: A pilot proof-of-concept study
Authors: Sparwasser P. , Haack M. , Frey L. , Boehm K. , Boedecker C. , Huber T. , Stroh K. , Brandt M. P. , Mager R. , Höfner T. , Tsaur I. , Haferkamp A. , Borgmann H.
Published: July 2022

Purpose

While several biopsy techniques and platforms for magnetic resonance imaging (MRI)-guided targeted biopsy of the prostate have been established, none of them has proven definite superiority. Augmented and virtual reality (mixed reality) smartglasses have emerged as an innovative technology to support image-guidance and optimize accuracy during medical interventions. We aimed to investigate the benefits of smartglasses for MRI-guided mixed reality-assisted cognitive targeted biopsy of the prostate.

Methods

For prospectively collected patients with suspect prostate PIRADS lesions, multiparametric MRI was uploaded to a smartglass (Microsoft® Hololens I), and smartglass-assisted targeted biopsy (SMART TB) of the prostate was executed by generation of a cognitive fusion technology at the point-of-care. Detection rates of prostate cancer (PCA) were compared between SMART TB and 12-core systematic biopsy. Assessment of SMART-TB was executed by the two performing surgeons based on 10 domains on a 10-point scale ranging from bad (1) to excellent (10).

Results

SMART TB and systematic biopsy of the prostate were performed for 10 patients with a total of 17 suspect PIRADS lesions (PIRADS 3, n = 6; PIRADS 4, n = 6; PIRADS 5, n = 5). PCA detection rate per core was significant (p < 0.05) higher for SMART TB (47%) than for systematic biopsy (19%). Likelihood for PCA according to each core of a PIRADS lesion (17%, PIRADS 3; 58%, PIRADS 4; 67%, PIRADS 5) demonstrated convenient accuracy. Feasibility scores for SMART TB were high for practicality (10), multitasking (10), execution speed (9), comfort (8), improvement of surgery (8) and image quality (8), medium for physical stress (6) and device handling (6) and low for device weight (5) and battery autonomy (4).

Conclusion

SMART TB has the potential to increase accuracy for PCA detection and might enhance cognitive MRI-guided targeted prostate biopsy in the future.
A complete guide to human microbiomes: Body niches, transmission, development, dysbiosis, and restoration
Authors: Reynoso-García Jelissa , Miranda-Santiago Angel E. , Meléndez-Vázquez Natalie M. , Acosta-Pagán Kimil , Sánchez-Rosado Mitchell , Díaz-Rivera Jennifer , Rosado-Quiñones Angélica M. , Acevedo-Márquez Luis , Cruz-Roldán Lorna , Tosado-Rodríguez Eduardo L. , Figueroa-Gispert María Del Mar , Godoy-Vitorino Filipa
Published: July 2022

Humans are supra-organisms co-evolved with microbial communities (Prokaryotic and Eukaryotic), named the microbiome. These microbiomes supply essential ecosystem services that play critical roles in human health. A loss of indigenous microbes through modern lifestyles leads to microbial extinctions, associated with many diseases and epidemics. This narrative review conforms a complete guide to the human holobiont—comprising the host and all its symbiont populations- summarizes the latest and most significant research findings in human microbiome. It pretends to be a comprehensive resource in the field, describing all human body niches and their dominant microbial taxa while discussing common perturbations on microbial homeostasis, impacts of urbanization and restoration and humanitarian efforts to preserve good microbes from extinction.
Infection Dynamics of Clostridium perfringens Fingerprinting in Buffalo and Cattle of Punjab Province, Pakistan
Authors: Zafar Khan Muhammad Umar , Khalid Shumaila , Humza Muhammad , Yang Shunli , Alvi Mughees Aizaz , Munir Tahir , Ahmad Waqar , Iqbal Muhammad Zahid , Tahir Muhammad Farooq , Liu Yongsheng , Zhang Jie
Published: July 2022

Clostridium perfringensproduces core virulence factors that are responsible for causing hemorrhagic abomasitis and enterotoxemia making food, animals, and humans susceptible to its infection. In this study,C. perfringenswas isolated from necropsied intestinal content of buffalo and cattle belonging to four major bovine-producing regions in the Punjab Province of Pakistan for the purpose offind out the genetic variation. Out of total 160 bovine samples (n: 160), thirty-three (n: 33) isolates ofC. perfringenswere obtained from buffalo (Bubales bubalis) and cattle (Bos indicus) that were further subjected to biochemical tests; 16S rRNA based identification and toxinotyping was done using PCR (Polymerase Chain Reaction) and PFGE (Pulse Field Gel Electrophoresis) pulsotypesfor genetic diversity. Occurrence ofC. perfringenswas found to be maximum in zone-IV (Bhakkar and Dera Ghazi Khan) according to the heatmap. Correlation was found to be significant and positive among the toxinotypes (α-toxin, and ε-toxin). Response surface methodology (RSM)viacentral composite design (CCD) and Box-Behnken design (BBD) demonstrated substantial frequency ofC. perfringensbased toxinotypes in all sampling zones. PFGE distinguished all isolates into 26 different pulsotypes usingSmaIsubtyping. Co-clustering analysis based on PFGE further decoded a diversegenetic relationship among the collected isolates. This study could help us to advance toward disease array ofC. perfringensand its probable transmission and control. This study demonstrates PFGE patterns from Pakistan, and typing ofC. perfringensby PFGE helps illustrate and mitigate the incidence of running pulsotypes.
Antitumor Effects of Cannabinoids in Human Pancreatic Ductal Adenocarcinoma Cell Line (Capan-2)-Derived Xenograft Mouse Model
Authors: Sakarin Siriwan , Meesiripan Nuntana , Sangrajrang Suleeporn , Suwanpidokkul Nuntakan , Prayakprom Piyaporn , Bodhibukkana Chatchada , Khaowroongrueng Vipada , Suriyachan Kankanit , Thanasittichai Somchai , Srisubat Attasit , Surawongsin Pattamaporn , Rattanapinyopituk Kasem
Published: July 2022

Background

Pancreatic cancer is considered a rare type of cancer, but the mortality rate is high. Cannabinoids extracted from the cannabis plant have been interested as an alternative treatment in cancer patients. Only a few studies are available on the antitumor effects of cannabinoids in pancreatic cancer. Therefore, this study aims to evaluate the antitumor effects of cannabinoids in pancreatic cancer xenografted mouse model.

Materials and Methods

Twenty-five nude mice were subcutaneously transplanted with a human pancreatic ductal adenocarcinoma cell line (Capan-2). All mice were randomly assigned into 5 groups including negative control (gavage with sesame oil), positive control (5 mg/kg 5-fluorouracil intraperitoneal administration), and cannabinoids groups that daily received THC:CBD, 1:6 at 1, 5, or 10 mg/kg body weight for 30 days, respectively. Xenograft tumors and internal organs were collected for histopathological examination and immunohistochemistry.

Results

The average tumor volume was increased in all groups with no significant difference. The average apoptotic cells and caspase-3 positive cells were significantly increased in cannabinoid groups compared with the negative control group. The expression score of proliferating cell nuclear antigen in positive control and cannabinoids groups was decreased compared with the negative control group.

Conclusions

Cannabinoids have an antitumor effect on the Capan-2-derived xenograft mouse model though induce apoptosis and inhibit proliferation of tumor cells in a dose-dependent manner.
Speech GAU: A Single Head Attention for Mandarin Speech Recognition for Air Traffic Control
Authors: Zhang Shiyu , Kong Jianguo , Chen Chao , Li Yabin , Liang Haijun
Published: July 2022

The rise of end-to-end (E2E) speech recognition technology in recent years has overturned the design pattern of cascading multiple subtasks in classical speech recognition and achieved direct mapping of speech input signals to text labels. In this study, a new E2E framework, ResNet–GAU–CTC, is proposed to implement Mandarin speech recognition for air traffic control (ATC). A deep residual network (ResNet) utilizes the translation invariance and local correlation of a convolutional neural network (CNN) to extract the time-frequency domain information of speech signals. A gated attention unit (GAU) utilizes a gated single-head attention mechanism to better capture the long-range dependencies of sequences, thus attaining a larger receptive field and contextual information, as well as a faster training convergence rate. The connectionist temporal classification (CTC) criterion eliminates the need for forced frame-level alignments. To address the problems of scarce data resources and unique pronunciation norms and contexts in the ATC field, transfer learning and data augmentation techniques were applied to enhance the robustness of the network and improve the generalization ability of the model. The character error rate (CER) of our model was 11.1% on the expanded Aishell corpus, and it decreased to 8.0% on the ATC corpus.