bluuebunny/crossref_metadata_2025 huggingface dataset:
LEADS+ Developmental Model: Proposing a new model based on an integrative conceptual review
Authors: Ramelli Sandra , Lal Sarrah , Sherbino Jonathan , Dickson Graham , Chan Teresa
Published: February 2023

Purpose: Leaders in academic health sciences centres (AHCs)
must navigate multiple roles as an inherent component of their
positions. Changing accountabilities, varying expectations, differing
leadership competencies required of multiple leadership roles can be
exacerbated by health system disruption, such as during the COVID-19
pandemic. We need improved models that support leaders in navigating, so
they can better handle the complexity of multiple leadership roles.

Method: This integrative conceptual review sought to examine
leadership and followership constructs and how they intersect with
current leadership practices in AHCs. The goal was to develop a refined
model of health care leadership development. The authors used iterative
cycles of divergent and convergent thinking to explore and synthesize
various literature and existing leadership frameworks. The authors used
simulated personas and stories to test the model and, finally, the
approach sought feedback from knowledge users (including health care
leaders, medical educators, and leadership developers) to offer
refinements.

Results: After five rounds of discussion and reformulation, the
authors arrived at a refined model: the LEADS+ Developmental
Model. The model describes four nested stages, organizing progressive
capabilities, as an individual toggles between followership and
leadership. During the consultation stage, feedback from 29 out of 65
recruited knowledge users (44.6% response rate) was acquired. More than
a quarter of respondents served as a senior leader in a health care
network or national society (27.5%, n=8).  Consulted knowledge users
were invited to indicate their endorsement for the refined model using a
10-point scale (10=highest level of endorsement). There was a high level
of endorsement: 7.93 (SD 1.7) out of 10.

Conclusion: The LEADS+ Developmental Model may help
foster development of academic health centre leaders. In addition to
clarifying the synergistic dynamic between leadership and followership,
this model describes the paradigms adopted by leaders within health
systems throughout their development journey.
Bubble interfacial area in a swirling contactor: Experiments and CFD simulations
Authors: Xu Xiao , Gong Chunkai , Wang Shuo , Yang Qiang
Published: February 2023

The bubble size, gas holdup, and interfacial area in a swirling
contactor were investigated through experiments and simulations. The
interfacial area was obtained for liquids and gases with Reynolds
numbers Re and
Re, respectively. The contactor was
divided into 12 subregions. When Re=23.8
and Re =20075.4, regions near the side
wall and center of the swirl contactor exhibited small bubbles with
diameters of 0.33–0.40 and 0.38–0.45 mm, respectively.
Re was negatively related to bubble size,
gas holdup, and interfacial area, whereas
Re was positively related. The maximum
bubble interfacial area among the 12 subregions was 530
m,and for the entire swirling contactor was 196.3
m with a gas–liquid ratio of 0.022. Euler-Euler
simulations using the population balance model accurately predicted this
area. Larger areas were obtained at lower
Re values. Increasing the liquid velocity
is not necessary to achieve larger areas, which indicates a contactor
with lower energy consumption.
Preoperative predictors of worsened respiratory status after patent ductus arteriosus ligation in preterm infants.
Authors: Yang Hyo Ju , Park Seul Gi , Lim Soo Yeon , Kim Seh Hyun , Shin Seung Han , Kim Ee-Kyung , Kim Han-Suk
Published: February 2023

Introduction: Surgical ligation for hemodynamically significant
patent ductus arteriosus (PDA) is sometimes required in preterm infants;
however, some patients experience worsened respiratory status after the
surgery. This study aimed to evaluate the risk factors that could
predict worsened respiratory outcomes after PDA ligation.
Methods: A retrospective cohort study was performed on 57
preterm infants born at less than 32 weeks of gestational age and in
whom the PDA was surgically ligated between January 2014 and December
2018 at Seoul National University Children’s Hospital. Participants were
divided into two groups: infants with worsened respiratory outcomes 14
days after ligation and control. Worsened respiratory outcome was
defined as increase in respiratory severity score (RSS) by 30% or more
at 14 days after ligation compared to RSS before ligation, or death at
14 days after ligation. Results: Among the 57 PDA-ligated
infants, 12 had worsened respiratory outcomes and 45 did not. The
worsened respiratory outcomes were associated with oligohydramnios
(adjusted OR 1.373, 95% CI 1.113-1.694.), histologic chorioamnionitis
(adjusted OR 1.240, 95% CI 1.016-1.512), and decreased weight on the
day of surgery (adjusted OR 0.999, 95% CI 0.999-0.999) compared to that
in the control. Conclusion: Worsened respiratory outcomes after
PDA ligation appeared to be associated with oligohydramnios, histologic
chorioamnionitis, and weight on the day of surgery.
Disparities in Lung Transplantation in Children
Authors: Brugha Rossa , Wu Diana , Spencer Helen , Marson Lorna
Published: February 2023

Lung transplantation is a recognised therapy for end stage respiratory
failure in children and young people. It is only available in selected
countries, and is limited by access to suitable organs. Data on
disparities in access and outcomes for children undergoing lung
transplantation are limited. It is clear that data from studies in
adults, and from studies in other solid organ transplants in children,
that systemic iniquities exist in this field. While data relating
specifically to paediatric lung transplantation are relatively sparse,
professionals should be aware of the risk that health care systems may
result in disparities in access and outcomes following lung
transplantation in children.
Spontaneous Globe Rupture in Infant with Retinoblastoma
Authors: Ng Hannah , Sloan Brian , SP Yvonne , Chong Chee Foong
Published: February 2023

This article describes spontaneous globe rupture as a rare but serious
complication of retinoblastoma. This warrants acknowledgement and
discussion, given the implications for metastatic spread should it not
be managed appropriately.
A case of fulminant myocarditis with full recovery after a 38-h sustained asystole
Authors: Akutsu Tomohiro , Endo Akira , Sonobe Hiroyuki , Suzuki Keisuke , Murata Kiyoshi , Otomo Yasuhiro
Published: February 2023

A 69-year-old man was diagnosed with fulminant myocarditis with
circulatory collapse. His cardiac rhythm deteriorated to asystole on the
second day; however circulatory status was maintained through
extracorporeal membrane oxygenation and intra-aortic balloon pumping.
After 38h-lasting asystole, heart resumed beating. He was discharged
without neurological deficits on day 25.
A NOVEL TECHNIQUE OF PLACING RIGHT VENTRICLE LEADS IN PATIENTS WITH PERSISTENT LEFT SUPERIOR VENA CAVA
Authors: García-Cano Laura , Brouzet Thomas , Criado Jose Luis Ibañez , García-Fernández Amaya , Monteagudo-Viana Marta , Martinez Juan Gabriel , Criado Alicia Ibañez
Published: February 2023

Background: Persistent left superior vena cava is the most common
thoracic venous anomaly. It is usually asymptomatic, but it can make it
difficult to implant intracardiac devices . Case presentation: We
present a novel technique to facilitate right ventricular lead
implantation in two patients with persistent left superior vena cava and
the absence of the right superior vena cava. We used a fixed-curve
Selectra 3D sheath (Biotronik), orienting the sheath towards the
tricuspid valve by rotating it in a counter-clockwise direction. During
follow-up, the electrodes remained stable. Discussion: Our
technique was safe, simple and feasible for patients with this complex
venous anatomy.
Designs and operations of heat integrated reactors for thermochemically producing hydrogen from methanol by steam reforming
Authors: Chen Junjie
Published: February 2023

Endothermic reactions performed in microreactors are driven using heat
from an external source. However, the temperature of the gas stream
providing the heat is limited by constraints imposed by the materials of
construction. The present study is focused primarily upon the designs
and operations of heat integrated reactors for thermochemically
producing hydrogen from methanol by steam reforming. A symmetry boundary
condition is used to model half of each system where symmetry exists.
Computations are performed using grids with varying nodal densities to
determine the optimum node spacing and density that would give the
desired accuracy and minimize computation time. The final grid density
is determined when the centerline profiles of temperature and species
concentration do not show obvious difference. The second-order upwind
scheme is used to discretize the mathematical model, and the
semi-implicit method for pressure-linked equations algorithm is employed
to solve for the pressure and velocity fields. The convergence is judged
upon the residuals of all governing equations. The present study aims to
provide a fundamental understanding of the designs and operations of
heat integrated reactors for thermochemically producing hydrogen from
methanol by steam reforming. Particular emphasis is placed upon the
effect of various factors on the thermochemical steam reforming
processes in heat integrated reactors. The results indicate that steam
reforming produces hydrogen and carbon monoxide when heat is added to a
catalytic reactor containing steam and hydrocarbons. Alternating channel
parallel plate designs can be applied to thermally coupling endothermic
steam reforming with combustion in neighboring channels. Balancing the
heat requirements of an endothermic reaction with heat generated by an
exothermic reaction flowing parallel to and on the opposite side of a
separating plate is extraordinarily difficult since the endothermic
reaction is likely to have a very different dependence upon
concentration and temperature than the endothermic reaction. A
convenient way to supply heat is to couple the endothermic reaction with
an exothermic combustion reaction in the heat exchange channels. The
process gas is raised in temperature and this energy can be utilized by
the reforming process. The catalyst coating thickness depends upon the
process proceeding within the catalyst matrix. The arrangement leads to
improved heat transfer and therefore chemical conversion. Heterogeneous
combustion aids in spreading the heat generation along the length of the
channel and helps prevent hotspot formation.

Keywords: Hydrogen production; Endothermic reactions; Discrete
channels; Flow arrangements; Chemical conversion; Heterogeneous
combustion
A late Pleistocene Wood Turtle (Glyptemys insculpta) from Iowa, USA: response of the taxon to glaciation and formation of the current range
Authors: Hill Matthew
Published: February 2023

The partial shell of a Wood Turtle (Glyptemys insculpta) was collected from the West Branch of the East Nishnabotna River in southwestern Iowa, near Malvern. By direct accelerator mass spectrometry, it radiocarbon dates to the late Pleistocene (10 220 ± 30 years before present [BP], 11 975–11 813 calibrated years [cal] BP). Other subfossil evidence indicates that Wood Turtles moved far south of their current range, into the southeastern United States, in response to late Pleistocene glaciation. The specimen suggests that the species also moved south and west, into a previously undocumented western range, where favourable habitat and, in particular, somewhat cooler summer temperatures prevailed until ~10 200 cal BP. My assessment of the Holocene subfossil record suggests that establishment of the western portion of the current range may have occurred within the past 1000 years. Phylogenetic analysis and direct radiometric dating of subfossil specimens are needed to determine additional details about the late Pleistocene dispersal of Wood Turtle and the postglacial formation of their current range.
Tabusintac Bay (New Brunswick, Canada): an important spring migratory stopover for Atlantic Brant (Branta bernicla hrota)
Authors: Leblanc Mélanie-Louise , Hanson Alan , LaRocque Armand , Leblon Brigitte , Humphries Murray
Published: February 2023

Atlantic Brant (Branta bernicla hrota) is an Arctic-breeding migratory waterfowl that relies heavily on Common Eelgrass (Zostera marina) for food during migration and overwintering. Although the abundance of Atlantic Brant along the coasts of the Maritime provinces has declined drastically over the past decades, some flocks continue to migrate through the area in spring. Here, we present field observations of Atlantic Brant spring staging in the Tabusintac Bay, New Brunswick, Canada. We surveyed the Tabusintac Bay seven times between 26 May and 6 June 2018. We observed a maximum daily count of 1259 individuals, which is comparable to high counts from the 1970s. These spring surveys indicate the continuing importance of Tabusintac Bay to Atlantic Brant for spring staging. There is a pressing need to increase monitoring and research in the region and to preserve or enhance the quality of the area for spring staging brant.
Salmon Shark (Lamna ditropis) scratching behaviour using floating anthropogenic debris
Authors: Du Preez Cherisse , Gartner Heidi , Watts Joshua , Clark Lindsay , Du Preez Shelton , Norgard Tammy
Published: February 2023

Observations of animal behaviour in the open ocean are relatively rare. However, while conducting surveys in the Northeast Pacific in the summers of 2019 and 2021, we encountered two Salmon Shark (Lamna ditropis) using floating anthropogenic debris to scratch their bodies. We captured the activity with aerial (drone) and underwater cameras. We document and describe this novel behaviour as high energy, high impact, repetitive, fast, and long lasting (e.g., every ~15 s for >20 minutes). We explore these observations in light of traditional ecological knowledge and scientific literature.
A framework for privacy-aware and secure decentralized data storage
Authors: Aslam Sidra , Mrissa Michael
Published: February 2023

Blockchain technology gained popularity thanks to its decentralized and transparent features. However, it suffers from a lack of privacy as it stores data publicly and has difficulty to handle data updates due to its main feature known as immutability. In this paper, we propose a decentralized data storage and access framework that combines blockchain technology with Distributed Hash Table (DHT), a role-based access control model, and multiple encryption mechanisms. Our framework stores metadata and DHT keys on the blockchain, while encrypted data is managed on the DHT, which enables data owners to control their data. It allows authorized actors to store and read their data in a decentralized storage system. We design REST APIs to ensure interoperability over the Web. Concerning data updates, we propose a pointer system that allows data owners to access their update history, which solves the issue of data updates while preserving the benefits of using the blockchain. We illustrate our solution with a wood supply chain use case and propose a traceability algorithm that allows the actors of the wood supply chain to trace the data and verify product origin. Our framework design allows authorized users to access the data and protects data against linking, eavesdropping, spoofing, and modification attacks. Moreover, we provide a proof-of-concept implementation, security and privacy analysis, and evaluation for time consumption and scalability. The experimental results demonstrate the feasibility, security, privacy, and scalability of the proposed solution.
Multi-perspective approach for curating and exploring the history of climate change in Latin America within digital newspapers
Authors: Vargas-Solar Genoveva , Zechinelli-Martini José-Luis , Espinosa-Oviedo Javier , Vilches-Blázquez Luis
Published: February 2023

This paper introduces a multi-perspective approach to deal with curation and exploration issues in historical newspapers. It has been implemented in the platform LACLICHEV (Latin American Climate Change Evolution platform). Exploring the history of climate change through digitalized newspapers published around two centuries ago introduces four challenges: (1) curating content for tracking entries describing meteorological events; (2) processing (digging into) colloquial language (and its geographic variations5) for extracting meteorological events; (3) analyzing newspapers to discover meteorological patterns possibly associated with climate change; (4) designing tools for exploring the extracted content. LACLICHEV provides tools for curating, exploring, and analyzing historical newspaper articles, their description and location, and the vocabularies used for referring to meteorological events. This platform makes it possible to understand and identify possible patterns and models that can build an empirical and social view of the history of climate change in the Latin American region.
Guest editorial - Parallel and distributed computing and applications
Authors: Shen Hong , Tian Hui , Sang Yingpeng
Published: February 2023

nema
Guest editorial - Engineering of computer based systems
Authors: Djukic Miodrag , Popovic Miroslav
Published: February 2023

nema
Age of diagnosis does not alter the presentation or progression of robustly defined adult-onset type 1 diabetes
Authors: Thomas Nicholas.J , Hill Anita.V , Dayan Colin.M , Oram Richard.A , McDonald Timothy.J , Shields Beverley.M , Jones Angus.G , group the StartRight Study
Published: February 2023

  

Aims

To determine whether presentation, progression and genetic susceptibility of robustly defined adult-onset type 1 diabetes (T1D) are altered by diagnosis age.

Methods 

We compared the relationship between diagnosis age and presentation, C-peptide loss (annual change in Urine C-peptide Creatinine Ratio (UCPCR)) and genetic susceptibility (T1D genetic risk Score (T1DGRS)) in adults with confirmed T1D in the prospective StartRight study, 1,798 adults with new-onset diabetes. T1D was defined in two ways: ≥2 positive islet-autoantibodies (of GADA, IA-2A, ZNT8A) irrespective of clinical diagnosis(n=385), or 1 positive islet-autoantibody and a clinical diagnosis of T1D(n=180). 

Results 

In continuous analysis age of diagnosis was not associated with C-peptide loss for either definition of T1D [p>0.1], with mean(95% CI) annual C-peptide loss in those diagnosed before and after age 35 (median age of T1D defined by ≥2 positive autoantibodies): 39(31-46)% vs 44(38-50)% with ≥2 positive islet-autoantibodies and 43(33-51)% vs 39(31-46)% with clinician diagnosis confirmed by 1 positive islet-autoantibody [p>0.1]. Baseline C-peptide and T1DGRS were unaffected by age of diagnosis or T1D definition [p>0.1]. In T1D defined by ≥2 autoantibodies, presentation severity was similar in those diagnosed before and after age 35: unintentional weight loss 80(95% CI 74-85)% vs 82(76-87)%, ketoacidosis 23(17-29)% vs 19(14-25)% and presentation glucose 21(19-22) mmol/l vs 21(20-22) mmol/l [all p≥0.1]. Despite similar presentation, older adults were less likely to be diagnosed with T1D, insulin treated, or admitted to hospital.  

Conclusions 

When adult-onset T1D is robustly defined the presentation characteristics, progression, and T1D genetic susceptibility are not altered by age of diagnosis. 
Performance of the Dexcom G6 Continuous Glucose Monitoring (CGM) system during cardiac surgery using hypothermic extracorporeal circulation
Authors: Herzig David , Vettoretti Martina , P. Guensch Dominik , Melmer Andreas , Schürch Daniel , Roos Jonathan , Goerg Arna M. C. , Krutkyte Gabija , Cecchini Luca , Facchinetti Andrea , Vogt Andreas P , Bally Lia
Published: February 2023

  

Background

Continuous glucose monitoring (CGM) may be challenged by extreme conditions during cardiac surgery using hypothermic extracorporeal circulation (ECC).

Research Design and Methods

We evaluated the Dexcom G6 sensor in 16 subjects undergoing cardiac surgery with hypothermic ECC, of whom 11 received deep hypothermic circulatory arrest (DHCA). Arterial blood glucose, quantified by the Accu-Chek Inform II meter, served as reference. 

Results 

Intra-surgery mean absolute relative difference (MARD) of 256 paired CGM/reference values was 23.8%. MARD was 29.1% during ECC (154 pairs) and 41.6% immediately after DHCA (10 pairs), with a negative bias (signed relative difference: -13.7%, -26.6% and -41.6%). During surgery, 86.3% pairs were in Clarke error grid Zones A or B and 41.0% of sensor readings fulfilled the ISO 15197:2013 norm. Post-surgery, MARD was 15.0%.

Conclusions

Cardiac surgery using hypothermic ECC challenges the accuracy of the Dexcom G6 CGM although recovery appears to occur thereafter. 
Cellular and molecular mechanisms of pulmonary malformations
Authors: Blinova S. A , Oripov F. S , Khamidova F. M
Published: February 2023

Until now, the cellular and molecular mechanisms of the development of lung defects remain a poorly studied area of pulmonology. In the occurrence of anomalies in the airways of the lungs, a change in the expression of proteins that control early lung morphogenesis in normal conditions (proteins FGF, TGF, SHH, WNT) was established. Along with this, bronchial markers and markers of type 2 alveolocytes play a certain role in the occurrence of lung defects. A number of congenital malformations are caused by improper formation of the airways, which may be associated with the influence of various soluble factors, receptors, transcription factors and microRNAs. The possible role of the pulmonary neuroendocrine system (apudocytes and neuroepithelial bodies) in the pathogenesis and pathobiology of childhood lung diseases, including congenital lung diseases, is discussed.
The hipotises of the immune system's role in carcinogenesis
Authors: Slepov Y. K , Laushkin M. A , Deev R. V
Published: February 2023

The presented controversial hypothesis is an attempt to reflect on the role of the adaptive immune response in carcinogenesis. It is a well-known fact that the most of the signaling pathways which are participating in embryogenesis and regeneration are also active in tumor growth. Considering their presence in different evolutionary groups, there's such a contradiction that with same mechanisms of proliferation, animals with high regenerative potential are less predisposed to malignancy than mammals. Comparing these two groups, it's being discovered that despite the importance of immune control as a factor impeding carcinogenesis, the animals' immune system with high regenerative potential is less developed. The above is a reading of the complete or partial absence of the adaptive link of immunity. These described distinctions have formed the basis of the hypothesis of the procarcino-genic role of the adaptive immune response.
The role of transposons in the structural evolution of eukaryotic genomes
Authors: Mustafin R. N
Published: February 2023

We presented evidence of the role of transposons in the occurrence of centromeric repeats in plants and animals. During evolution, transposable elements are retained as part of centromeres and participate in interaction with kinetochore. Moreover, the centromere protein CENP-B, telomerase and telomeres were derived from transposons. For the functioning of centromeres, the necessary role of RNA interference was proved. Non-coding RNAs that are processed from centromere transcripts are involved in this process. We assume that this property was acquired due to the protective mechanisms of the hosts against transposons, which have been successfully used for the regulation of genomes. As a result, the universal mechanism of chromosomes during mitosis was formed for all eukaryotes, since transposons play a global role in the structural and functional regulation of genomes. Evolutionary kinship of transposons with viruses, which are characterized by interactions with microtubule tubulin, is proved. Moreover, bacteriophages encode tubulin-like PhuZ protein. In evolution, spliceosomal introns, epigenetic and transcription factors and their binding sites, non-coding RNAs and many protein-coding genes have evolved from transposons. These facts indicate the evolutionary formation of a complex system of regulation of cell functions involving transposons and the role of transposons in the structural evolution of genomes.
Transposon hypothesis of carcinogenesis
Authors: Mustafin R. N
Published: February 2023

The hypothesis is presented according to which the key drivers of carcinogenesis are transposons causing genomic instability, activation of oncogenes and inactivation of oncosuppressor genes. Expression of retroelements is under the negative regulatory control of proteins p53, RB1, VHL, BRCA1, ATM. It is assumed that most oncosuppressors have this property, since their genes are characterized by the presence in their composition of mobile elements (causing recombinations upon their activation) and hot spots of insertional mutagenesis. Accordingly, suppression of the expression of transposons as an adaptive process is necessary to ensure the stability of these genes. Therefore, the development of neoplasms in hereditary tumor syndromes may be due to pathological activation of transposons, which cause mutation of the second allele and other oncosuppressor genes due to congenital deficiency of oncosuppressor. Identical mechanisms are likely for sporadic carcinogenesis, when an activated transposon moves to new loci, causes complex genomic rearrangements specific to neoplasms, and inactivates oncosuppressors. Since the sequences of the transposable elements serve as alternative promoters for many genes, their activation causes enhanced expression of oncogenes in carcinogenesis. The transposons located in introns facilitate the transcription of chimeric molecules that have a pronounced oncogenic activity. In addition, mobile elements are sources of oncogenic microRNAs and long noncoding RNAs. The same microRNAs affect both neoplasms and aging, which confirms the hypothesis put forward, since dysregulation of mobile elements occurs with age, and aging is associated with an increased risk of cancer developing.
Allele expression of Peroxisome-gamma2 proliferation activator receptor gene in overweight eldery patients with ischemic heart disease
Authors: Folomeeva L. I , Filippov E. V
Published: February 2023

It is known that about a third of the world's population suffers from obesity. Peroxisome activation receptors, namely, the γ2 promoter, is abundantly locatein adipose tissue, regulating adipogenesis, lipid accumulation, and glucose homeostasis. The aim of this investigations was to study the expression features of the PPARγ2 gene alleles in elderly patients with comorbid conditions such as obesity and ischemic heart disease. From 2017 to 2019 in "Clinical Hospital № 29 named. N.E. Bauman” (Moscow) 140 patients of both sexes (54.3% men and 45.7% women) aged 60-89 years were examined by us. The main group included 70 pts with ischemic heart disease, and the control group included 70 pts without it. Pro12 allele carriage in the main group had 85%, and the Ala12 allele - 15%. Pro12Ala and Ala12Ala genotypes, Ala12 allele were detected more often in patients with ischemic heart disease than in the control group (p=0.0008 and p=0.0003, respectively). Pro12Ala genotypes carriage (OR=2.02, CI = 1.28-3.19, p=0.003) and Ala12Ala (OR=2.002, CI = 1.32-3.04, p=0.0006) of the Ala12 gene PPARγ2 increases the risk of developing ischemic heart disease by 2 times. The revealed features of the expression of PPARγ2 gene alleles in elderly patients with obesity and ischemic heart disease e confirm the ability of nuclear PPARs to control development, differentiation, metabolic homeostasis and reproduction. To clarify the role of various genotypes of the PPARy2 gene in the regulation of lipid metabolism and angiogenesis in the discussed comorbid conditions in elderly patients may help to identify new methods of it treatment.
Distribution of cytokeratins and vimentin in rats liver at various stages of ontogenesis
Authors: Dvoryashina I. A , Velikorodnaya Yu. I , Terent'ev A. V , Zagrebin V. L
Published: February 2023

In recent years, there has been increasing understanding that the molecular mechanisms of liver morphogenesis are also involved in the mechanisms of regeneration and pathogenesis of some organ diseases. Epithelial-mesenchymal and mesenichymal-epithelial transitions play a significant role in embryogenesis, morphogenesis and regeneration. The aim of the study was to characterize the localization and ratio of epithelial and mesenchymal cells in the liver tissue during embryonic and postnatal development of rat liver as a possible criterion for mesenchymal-epithelial transition. We have analyzed immunohistochemically the production and distribution of vimen-tin (mesenchymal marker) and cytokeratin 18 (epithelial marker) in the liver tissue of rats from day 1 0 of embryonic development to adults. The relative area of hybrid cells has determined by double immunofluorescence followed by morphometry. The study showed that as the liver develops, the content of the epithelial marker (cy-tokeratin 18) increases, while the production of the mesenchymal marker (vimentin) decreases, with the exception of the period from 1 to 17 days after birth, when the amount of vimentin increases. In addition, hybrid cells were found in the liver of embryos on days 10 and 17 of gestation, which synthesized both intermediate microfilaments - vimentin and cytokeratin 1 8. Thus, based on the ratio of vimentin and cytokeratin 18 in the process of embryonic and postnatal liver morphogenesis and the presence of hybrid cells allow make an assumption about the origin of a part of hepatocytes by mesenchymal-epithelial transition.
Comparative characterization of cell products derived from adipose tissue using different systems for the isolation of cellular fractions
Authors: Gilmutdinova I. R , Kostromina E. Yu , Veremeev A. V , Putova M. V , Markov P. A , Kudryashova I. S , Eremin P. S
Published: February 2023

The use of autologous adipose tissue-derived cell products to restore the morphology and function of organs and tissues affected by the disease have become widespread in regenerative medicine. For the wide application of cell-based products in clinical practice, it is important to develop and implement new devices to automate and standardize the isolation of stromal vascular fraction cells. This work aimed to compare cell products obtained from human adipose tissue using two systems, both registered in the Russian Federation and based on enzymatic and mechanical methods of cell fractions isolation. As clinical material, we used samples of adipose tissue in the form of lipoaspirate obtained from healthy patients. The isolation of cell products was performed according to the instructions for the use of these systems. A comparative analysis of the effectiveness of these systems for the isolation of cell fractions was carried out by evaluating several parameters determined for obtained cell products. The cell product obtained by the enzymatic method is characterized by a high yield of nucleated cells, as well as a high proliferative potential of stem cells isolated from adipose tissue. The cellular product obtained from adipose tissue using the mechanical method is characterized by a low yield of nucleated cells, the presence of a large volume of residual oil, and destroyed connective tissue in the final product. The work shows that the method of adipose tissue processing (enzymatic or mechanical) has a significant effect on the characteristics of the products obtained.
Proliferative activity of cancer stem cells in the prognosis of hematogenous metastasis of colon adenocarcinoma
Authors: Erokhina A. A. , Chirsky V. S. , Maistrenko N. A. , Sazonov A. A. , Grigorev S. G.
Published: February 2023

The search for prognostic markers to determine the risk of dissemination and metastasis of colon adenocarcinoma is one of the most difficult and actual problems of modern oncomorphology.The aim of this work was to determine the possibility of using indicators of the proliferative activity of cancer stem cells in the prediction of hematogenous metastasis of colon adenocarcinoma. In this work the surgical material from 32 radically operated patients of different ages suffering from a localized colon adenocarcinoma was explored, and relapse-free survival was assessed. A comparative analysis of various components of the tumor differon, including proliferating stem cells and their relationship with the formation of relapse was carried out.An index of stem cell proliferation was proposed to assess the influence of stem cell activity on the biological behavior of tumor. The best rates of relapse-free survival were found in the group of patients with low value of the index of stem cell proliferation compared with patients which index took on high values, which is more typical for elderly and old patients. With a similar comparison of other indicators of tumor differon, including the percentage of ALDH1 and Ki-67-positive cells, as well as cells with the ALDH1+Ki-67+immenophenotype relative to the total tumor differon, no significant relationship with relapse-free survival was found. These results may indicate a high role of ALDH1+ cell proliferation in tumor dissemination, especially in elderly and senile patients, and a lesser influence of both the proliferative activity of Ki-67 and the general population of stem cells on the formation of distant metastases.
The role of polymorphic variants of the ERCC2 excision repair gene in the pathogenesis of ovarian cancer in women of different ethnic origins
Authors: Valova Y. V. , Mingazheva E. T. , Prokofieva D. S. , Andreeva E. A. , Nurgalieva A. Kh. , Ekomasova N. V. , Khusnutdinova E. K.
Published: February 2023

Malignant neoplasms of the ovaries are one of the most frequently diagnosed tumors of the female reproductive system and one of the leading causes of cancer death in women worldwide. Despite significant advances in the field of early diagnosis and treatment of the disease, the survival rate of patients with this form of oncopathology is still low, which dictates the need for further study of this problem. The aim of the work was to evaluate the role of polymorphic variants rs13181 and rs238406 of the ERCC2 gene in the development of hereditary and sporadic forms of ovarian cancer in women of different ethnicity from the Republic of Bashkortostan. The material for the study was DNA samples of women with sporadic forms of ovarian cancer (n=182), hereditary forms of ovarian cancer (n=65) and women without cancer at the time of blood sampling (n=292) of various ethnic origins. Genotyping was performed by polymerase chain reaction (PCR) followed by analysis of restriction fragment length polymorphism. As a result of the study, an association of the rs13181*C allele of the ERCC2 gene with the risk of developing hereditary and sporadic forms of ovarian cancer in women of Russian ethnicity was established. An association of the rs238406*GT genotype of the ERCC2 gene with the risk of developing sporadic forms of ovarian cancer was revealed. The data obtained indicate the involvement of the studied polymorphic variants in the pathogenesis of ovarian cancer in our region.
Meson spectroscopy at non-zero temperature using lattice QCD
Authors:   , García-Mascaraque Sergio Chaves
Published: February 2023

This thesis explores two main topics: the effects of the temperature on several Quantum Chromodynamics mesonic observables, with a concrete focus on the tem-perature dependence of the mesonic mass spectrum, and numerical spectral recon-struction of lattice correlation functions employing deep neural networks. In the first two chapters, a brief introduction to standard lattice Quantum Chromodynamics and non-zero temperature field theory is provided. Using the tools presented in the intro-ductory chapters, a complete spectroscopy analysis of the temperature dependence of several mesonic ground state masses is developed. From this study, novel results in the restoration of chiral symmetry as a function of the temperature are obtained by studying the degree of degeneracy between the ρ(770) and a1(1260) states. Ad-ditionally, a complete study of the thermal effects affecting the mesonic D(s)-sector below the pseudocritical temperature of the system is provided. A self-contained chapter discussing the pion velocity in the medium is also included in the document. The pion velocity is estimated as a function of the temperature using non-zero tem-perature lattice Quantum Chromodynamics. In addition, after providing a detailed introduction to the field of neural networks, their application to numerical spectral reconstruction is studied. A simple implementation in which deep neural networks are applied to numerical spectral reconstruction is tested in order to explore its limits and applicability.
Nilai-Nilai dan Kearifan Lokal Suku Makassar Sebagai Sumber Pendidikan Ekonomi Informal dalam Keluarga
Authors:   Universitas Negeri Makassar, M Yani , Hasan Muhammad , Supatminingsih Tuti
Published: February 2023

Local wisdom is an order of life values inherited from the previous generation to the next generation in the form of religion or religion, culture and customs in oral form in the social system of society. One of the local cultural wisdom of the Makassar tribe is the principle of life adopted by the people. The principle of life is the guide of people's lives in shaping their human character. This study aims to examine the principle of the life of the Makassar tribe, which is a source of informal economic education in the Family. The research method used is a descriptive qualitative research method in literature study with data sources coming from books or existing literature. The meaning of the Makassarese principle of life can be used as a source of informal economic education in the Family. The principle of the life of the Makassar tribe, which is the source of Informal Economic Education in the Family, includes: (1) the principle of not surrendering to circumstances; (2) solidarity and togetherness, and (3) self-esteem.
Sistem Informasi Reservasi dan Pembayaran Resto Berbasis QR Code
Authors: Rabbani Ariq
Published: February 2023

Kemajuan   teknologi   informasi   berkembang   dengan   sangat   pesat,   seiring meningkatnya  kebutuhan  manusia  akan  informasi  yang  dapat  di  terima  dengan  cepat, tepat,  dan  akurat.  Dimana  saat  ini  teknologi  telah menjamah  di  berbagai  bidang.  Salah satunya adalah website, dimana website telah ada sejak dulu dan hingga sekarang telah mengalami   perkembangan    yang   signifikan. Berdasarkan pengamatan, Kafe Dijou memiliki masalah yang berupa system reservasi masih berupa manual, di mana pengunjung harus membayar DP di tempat. Lalu system pendataan reservasi juga masih berupa manual sehingga data sering hilang karena kelalaian karyawan. Karena hal ini maka saya memutuskan untuk membuat website reservasi untuk mempermudah pengunjung dan karyawan Dijou dalam hal reservasi tempat. Hasilnya rancangan awal website sudah berhasil dibuat dan sudah teruji bisa digunakan untuk memesan meja dan menu.

Kata kunci Teknologi, website, reservasi.
Analysis of the Influence of Financial Literacy on Business Sustainability Through the Utilization of E-Commerce: A Study of MSMEs in the Food and Beverage Industry Sector in Balikpapan City
Authors: Piyani Henny Okta , Chandrarin Grahita , Sihwahjoeni
Published: February 2023

The purpose of this study is to obtain empirical evidence of the effect of financial literacy on business continuity, obtain empirical evidence of the effect of financial literacy on e-commerce utilization, obtain empirical evidence of the effect of e-commerce utilization on business continuity and obtain empirical evidence that e-commerce utilization mediates the effect of literacy. finance for the continuity of MSME businesses in the food and beverage industry sector in Balikpapan City. The sample in this study were 104 respondents. Data analysis technique using SEM PLS. The results of the analysis show that financial literacy has a positive effect on business continuity. Utilization of e-commerce has an effect on business continuity in a positive direction.
PENERAPAN PSAK 73 TERHADAP LAPORAN KEUANGAN DALAM MENINGKATKAN RELEVANSI LAPORAN KEUANGAN
Authors: Aprilia Visca Angga , Anggraini Ninik , Yani Ahmad
Published: February 2023

Perusahaan dituntut melaporkan laporan keuangannya secara relevan, adanya ketentuan PSAK 73 atas sewa. PSAK 73 atas sewa menentukan pengakuan, pengukuran, penyajian dan pengungkapan sewa bagi perusahan demi meningkatkan nilai relevansi. Tingkat relevansi yang tinggi membuat kebijakan diambil akan tepat oleh perusahaan. Penelitian ini adalah penelitian deskriptif dengan pendekatan kuantitatif. Jenis data penelitian adalah kuantitatif dan kualitatif. Teknik pengumpulan data penelitian adalah dokumentasi dan wawancara. Variabel penelitian adalah penerapan PSAK Nomor 73 tentang sewa, laporan keuangan dan relevansi laporan keuangan. Hasil penelitian ini adalah perusahaan melakukan pencatatan aset sewa hanya mencatat dengan model sewa operasi, hanya mencerminkan 1 tahun sewa. Penerapan PSAK No. 73 tentang sewa pada PT. Anugerah Beton Indonesia menjadikan laporan posisi keuangan bagian aset naik, sehingga dampak penerapan PSAK 73 menjadikan total aset, total liabilitas dan ekuitas perusahaan mengalami kenaikan. Peningkatan tersebut menunjukkan aset dan liabilitas yang dimiliki perusahaan pada tahun mendatang, sehingga penerapan PSAK No. 73 atas sewa mampu meningkatkan relevansi laporan posisi keuangan PT.Anugerah Beton Indonesia tahun 2021.
Pengembangan Media Pembelajaran Menggunakan Ispring Suite pada Mata Pelajaran IPA Kelas VIII SMP
Authors: Mardiansyah Mardiansyah , Zen Zelhendri , Bentri Alwen , Supendra Dedi
Published: February 2023

Penelitian ini memiliki tujuan untuk menghasilkan sebuah produk yakni learning environment untuk aplikasi iSpring Suite. Adapun jenis penelitian yang digunakan pada penelitian ini ialah pengembangan yang dikenal dengan penelitian dan pengembangan (R&D), model ADDIE digunakan sebagai model pengembangan. Proses pengembangan penelitian ini terdiri dari lima tahapan yakni analisis, desain, pengembangan, implementasi serta evaluasi. Kuesioner, dokumentasi dan formulir penilaian digunakan sebagai alat penelitian. Hasil validasi materi menghasilkan nilai 4,28 dengan kategori “Tepat”, sehingga materi dikatakan layak pakai, dari hasil validasi media saya mendapatkan nilai 4,85 “Sangat valid” dan validasi ahli media memberikan nilai II 4,69 “sangat sesuai”, artinya lingkungan tergolong lingkungan eksperimental. Selain itu, ujian praktik mahasiswa mendapat nilai 4,74 “sangat praktis”. Dari sini bisa diambil kesimpulan bahwa penggunaan Media Pembelajaran iSpring Suite dalam mata pelajaran IPA kelas VIII SMP dimungkinkan dan layak.
Persespsi Siswa Terhadap Kompetensi Pedagogik Guru Di SMP Negeri 3 Pariaman
Authors: Afifah Luthfiyyah , Zuwirna Zuwirna
Published: February 2023

Saat pembelajaran di dalam ataupun di luar kelas guru menjadi objek utama yang selalu dilihat siswa. Kunci yang paling penting agar siswa dapat belajar dengan baik adalah guru, karena guru merupakan fokus utama saat proses pembelajaran berlangsung. Siswa akan membentuk persepsi tentang gurunya, setiap siswa memiliki persepsi yang berbeda-beda. Siswa yang belajar dengan baik dapat memperoleh hasil yang baik dan merasa senang dalam belajar. Guru yang disenangi oleh siswa jauh lebih mudah dalam melakukan proses pembelajaran, karena siswa mempunyai persepsi yang baik pada gurunya, begitu juga sebaliknya. Oleh sebab itu, permasalahan yang akan dikaji dalam penelitian ini adalah “Bagaimana persepsi siswa terhadap komptensi pedagogik guru di SMP Negeri 3 Pariaman?” Penelitian ini bertujuan untuk mengetahui persepsi siswa terhadap kompetensi pedagogik guru ditinjau dari aspek menyelenggarakan pembelajaran yang mendidik, pemanfaatan teknologi pembelajaran, memfasilitasi pengembangan potensi peserta didik untuk mengaktualisasikan berbagai potensi yang dimiliki. berkomunikasi secara efektif, empatik, dan santun dengan peserta didik. Jenis penelitian ini merupakan penelitian deskriptif kuantitatif. Populasi pada penelitian ini adalah seluruh siswa kelas VIII SMP Negeri 3 Pariaman yang berjumlah 221 orang. Penarikkan sampel dilakukan dengan teknik simple random sampling menggunakan rumus Slovin dan memperoleh sampel sebanyak 69 orang. Alat pengumpulan data berupa angket dengan model Skala Likert. Hasil penelitian menunjukkan bahwa persepsi siswa terhadap kompetensi pedagogik guru, dilihat dari aspek: (1) menyelenggarakan pembelajaran yang mendidik berada pada kategori kuat dengan persentase 77,83%, (2) pemanfaatan teknologi pembelajaran berada pada kategori cukup dengan persentase 59,6%, (3) memfasilitasi pengembangan potensi peserta didik untuk mengaktualisasikan berbagai potensi yang dimiliki berada pada kategori kuat dengan persentase 74,80%, (4) berkomunikasi secara efektif, empatik, dan santun dengan peserta didik berada pada kategori kuat dengan skor rata-rata 77,65%. Secara keseluruhan disimpulkan persepsi siswa terhadap kompetensi pedagogik guru ada pada kategori kuat dengan persentase 74,75%
Pengembangan Media Pembelajaran Berbasis E-Flashcard pada Tema “Makanan Sehat” Kelas V Sekolah Dasar
Authors: Yunisa Putri Fenti , Yeni J Fetri , Syafril Syafril , Zuliarni Zuliarni
Published: February 2023

Penelitian ini bertujuan untuk menghasilkan media pembelajaran berbasis e-flashcard yang dapat membantu guru dalam proses pembelajaran dan meningkatkan motivasi belajar siswa. Media pembelajaran berbasis e-flashcard dikembangkan semenarik mungkin agar siswa lebih tertarik pada pembelajaran. Media dikembangkan dengan menggunakan software utama Adobe Flash CS6 dan software pendukung Adobe Photoshop.Penelitian ini menggunakan metodologi penelitian Research and Development (R&D), dengan menggunakan prosedur pengembangan model Borg and Gall. Kevalidan media diperoleh dari hasil validasi yang dilakukan oleh satu orang ahli materi dan dua orang ahli media. Hasil rata-rata yang diperoleh dari ahli materi yaitu 98,57% dengan kriteria “Sangat Layak” Hasil rata-rata yang diperoleh dari ahli media I yaitu 98,67% dan hasil rata-rata dari ahli media II yaitu 93,33%. Sehingga hasil keseluruhan diperoleh rata-rata sebesar 96% dengan kriteria “Sangat Layak”. Kepraktisan media diperoleh melalui angket praktikalitas siswa, uji praktikalitas dilakukan terhadap 20 orang siswa kelas V SDN 50/III Pematang Lingkung, yang memperoleh hasil 98,57% dengan kriteria “Sangat Praktis”. Hal ini menunjukkan bahwa media pembelajaran berbasis e-flashcard valid dan praktis digunakan pada tema makanan sehat kelas V sekolah dasar.
Perbandingan Hasil Belajar Metode Problem Based Learning dan Metode Problem Solving
Authors: Mahendra Goval , Usmeldi Usmeldi
Published: February 2023

This research was conducted with the aim of knowing the comparison of student learning outcomes using the Problem-Based Learning and Problem-Solving methods in the Basic Electrical and Electronics learning material for class X TITL SMK N 2 Kota Solok. The type of research used is Quasi-Experimental Design with the Pretest Posttest Nonequivalent Control Group Design method. Data analysis techniques use the normality test and homogeneity test, then use the t-test hypothesis test to make a decision. The results of hypothesis testing were carried out using the t-test and the results obtained were that the count value was smaller than the t-table at a significant level of 5%. Thus, it can be concluded that there is no significant difference in student learning outcomes in learning Basic Electricity and Electronics with the Problem-Based Learning and Problem-Solving methods at SMKN 2 Kota Solok.