bluuebunny/crossref_metadata_2025 huggingface dataset:
Mapping Evidence on Community-Based Clinical Education Models for Undergraduate Physiotherapy Students: Protocol for a Scoping Review (Preprint)
Authors: Chemane Nomzamo Charity Thobekile , Chetty Verusia , Cobbing Saul
Published: April 2020

BACKGROUND

Community-based clinical training has been advocated as an excellent approach to transformation in clinical education. Clinical education for undergraduate physiotherapy students is a hands-on practical experience that aims to provide a student with the skills necessary to enable them to be fit to practice independently. However, in many countries, including South Africa, this training has been conducted only in large urban academic hospitals. Such hospitals are not a true reflection of the environment that these students will most likely be facing as practicing health care professionals.

OBJECTIVE

The objective of this scoping review is to map out existing evidence on community-based clinical education models for undergraduate physiotherapy students globally.

METHODS

A systematic scoping review will be based on the 2005 Arksey and O’Malley framework. Studies involving students and stakeholders in clinical education will be included. This review will not be limited by time of publication. An electronic search of relevant literature, including peer-reviewed primary studies and grey literature, will be conducted from the PubMed, Google Scholar, Medline, CINAHL, and Cochrane Library databases. The search strategy will include keywords such as “education,” “physiotherapy,” “undergraduate,” “community-based,” “training,” “decentralized,” and “distributed.” Boolean logic will be used for each search string. Two independent reviewers will conduct screening of titles, abstracts, and full text before extracting articles. A predesigned data-charting table will supplement the extraction of data. Version 12 NVIVO software will aide in the thematic analysis of data.

RESULTS

Data collection will commence after publication of this protocol, and the results are expected to be obtained in the following 5 months.

CONCLUSIONS

The evidence obtained from the extracted data is expected to assist in the development of a model of community-based clinical education for undergraduate physiotherapy students in South Africa, and serve as a basis for future research. The discussion of this evidence will be guided by the research question utilizing a critical narrative approach to explore emerging themes. The enablers and barriers identified from the reviewed studies can guide the development of a community-based clinical education model.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/19039
Health Communication Through News Media During the Early Stage of the COVID-19 Outbreak in China: Digital Topic Modeling Approach (Preprint)
Authors: Liu Qian , Zheng Zequan , Zheng Jiabin , Chen Qiuyi , Liu Guan , Chen Sihan , Chu Bojia , Zhu Hongyu , Akinwunmi Babatunde , Huang Jian , Zhang Casper J P , Ming Wai-Kit
Published: April 2020

BACKGROUND

In December 2019, a few coronavirus disease (COVID-19) cases were first reported in Wuhan, Hubei, China. Soon after, increasing numbers of cases were detected in other parts of China, eventually leading to a disease outbreak in China. As this dreadful disease spreads rapidly, the mass media has been active in community education on COVID-19 by delivering health information about this novel coronavirus, such as its pathogenesis, spread, prevention, and containment.

OBJECTIVE

The aim of this study was to collect media reports on COVID-19 and investigate the patterns of media-directed health communications as well as the role of the media in this ongoing COVID-19 crisis in China.

METHODS

We adopted the WiseSearch database to extract related news articles about the coronavirus from major press media between January 1, 2020, and February 20, 2020. We then sorted and analyzed the data using Python software and Python package Jieba. We sought a suitable topic number with evidence of the coherence number. We operated latent Dirichlet allocation topic modeling with a suitable topic number and generated corresponding keywords and topic names. We then divided these topics into different themes by plotting them into a 2D plane via multidimensional scaling.

RESULTS

After removing duplications and irrelevant reports, our search identified 7791 relevant news reports. We listed the number of articles published per day. According to the coherence value, we chose 20 as the number of topics and generated the topics’ themes and keywords. These topics were categorized into nine main primary themes based on the topic visualization figure. The top three most popular themes were prevention and control procedures, medical treatment and research, and global or local social and economic influences, accounting for 32.57% (n=2538), 16.08% (n=1258), and 11.79% (n=919) of the collected reports, respectively.

CONCLUSIONS

Topic modeling of news articles can produce useful information about the significance of mass media for early health communication. Comparing the number of articles for each day and the outbreak development, we noted that mass media news reports in China lagged behind the development of COVID-19. The major themes accounted for around half the content and tended to focus on the larger society rather than on individuals. The COVID-19 crisis has become a worldwide issue, and society has become concerned about donations and support as well as mental health among others. We recommend that future work addresses the mass media’s actual impact on readers during the COVID-19 crisis through sentiment analysis of news data.
Knowledge and Perceptions of COVID-19 Among Health Care Workers: Cross-Sectional Study (Preprint)
Authors: Bhagavathula Akshaya Srikanth , Aldhaleei Wafa Ali , Rahmani Jamal , Mahabadi Mohammadjavad Ashrafi , Bandari Deepak Kumar
Published: April 2020

BACKGROUND

During the first week of March, the coronavirus disease 2019 (COVID-19) outbreak reached more than 100 countries with over 100,000 cases. Health care authorities have already initiated awareness and preparedness activities worldwide. A poor understanding of the disease among health care workers (HCWs) may result in delayed treatment and result in the rapid spread of the infection.

OBJECTIVE

This study aimed to investigate the knowledge and perceptions of HCWs about COVID-19.

METHODS

A cross-sectional, web-based study was conducted among HCWs about COVID-19 during the first week of March 2020. A 23-item survey instrument was developed and distributed randomly to HCWs using social media; it required 5 minutes to complete. A chi-square test was used to investigate the level of association among variables, with significance set to P<.05.

RESULTS

Of 529 participants, a total of 453 HCWs completed the survey (response rate: 85.6%); 51.6% (n=234) were male, 32.1% (n=147) were aged 25-34 years, and most were doctors (n=137, 30.2%) and medical students (n=134, 29.6%). Most participants (n=276, 61.0%) used social media to obtain information on COVID-19. A significant proportion of HCWs had poor knowledge of its transmission (n=276, 61.0%) and symptom onset (n=288, 63.6%) and showed positive perceptions of COVID-19. Factors such as age and profession were associated with inadequate knowledge and a poor perception of COVID-19.

CONCLUSIONS

As the global threat of COVID-19 continues to emerge, it is critical to improve the knowledge and perceptions of HCWs. Educational interventions are urgently needed to reach HCWs worldwide, and further studies are warranted.
Political Ecology Protection Spring Water in Batu
Authors: Romadhan Ach Apriyanto , Hardyanti Winda , Taqwa Iradhad , Nurkhanifah Laeli
Published: April 2020

Water resources management is a socio-political issue where various interests influence the policy on the protection and utilization of water resources. This research wants to know the government's policies and efforts in protecting water resources amid the rapid industrialization of tourism, along with conflicts due to the use of water resources from a political ecology perspective. This study uses descriptive qualitative research, data collection methods through depth interviews, observation, and documentation. This study shows that the efforts of the Batu City Government in realizing the protection of water resources are not proportional to the acceleration of the conversion of forest and agricultural land functions to support the sustainability of water resources due to the rapid growth of the tourism industry. It can be seen from the inconsistency of policy products, the imbalance in the amount of the budget between the commercialization of land (tourism), and the lack of efforts to conserve springs. As a result, there was resistance from the community in the struggle for access to water resources. Therefore, it is necessary to affirm the boundaries of the utilization of water resources supporting areas, transparency of the sustainability of water resources, and disclosure of information to the public regarding the process of tourism development plans undertaken by investors to facilitate supervision by the public.
Music, Fans and Fandom
Authors: O’Reilly Dr Daragh , Larsen Dr Gretchen , Kubacki Dr Krzysztof
Published: April 2020

Fans and fandom have been studied in a variety of different contexts, from soap operas to novels. Although there is a lot one can learn from studies about the characteristics of fandom and the behaviour of fans in general, research into music fans and fandom remains relatively scarce, with only a handful of works in the fields of popular music, marketing and consumer behaviour. Yet understanding music fans is crucial if one is to comprehend the production and consumption of music. For so many avid music consumers, the pleasures derived from music allows them to make sense of their everyday lives and experiences (Willis, 1990), ‘letting other people know who we are, or would like to be, what group we belong to, or would like to belong to’ (Shankar, 2000: 28). Music consumption is a very rich source of symbolic resources that can be drawn on by music fans to construct their individual and social identities. The purpose of this chapter is to explore fans and fandom in the context of music consumption and production. It builds on the earlier discussion in Chapter 7 on music consumption, where the frame of the music ‘fan’ was introduced. The chapter begins, therefore, with an attempt to provide a historical context for fans and fandom, and then outlines our understanding of fans and their behaviours and motivations. This is followed by an overview of fandom, its intensity and social organization. The chapter concludes with some observations on the material productivity of fans.
PENSAMENTO COMPUTACIONAL NA EDUCAÇÃO BÁSICA: ANÁLISE COM DISCENTES DO CURSO DE LICENCIATURA EM MATEMÁTICA
Authors: Reichert Janice Teresinha , Barone Dante Augusto Couto , Kist Milton
Published: April 2020

O artigo evidencia e discute aspectos sobre as percepções de um grupo de licenciandos em Matemática sobre o tema Pensamento Computacional, bem como, apresenta uma análise das possíveis contribuições de um curso de formação sobre o assunto.  O estudo centrou-se na aplicação de questionários com questões abertas e fechadas, antes e após a realização das atividades entre os meses de abril a julho de 2019. As respostas foram analisadas na perspectiva qualitativa sendo que os resultados obtidos apontam para um desconhecimento inicial dos participantes sobre o assunto, principalmente nas suas relações com a área da Matemática. O oferecimento do curso permitiu um ganho significativo sobre o assunto e a elaboração de conjecturas sobre a sua inclusão na Educação Básica.
DESENVOLVIMENTO DA ARITMÉTICA ESCOLAR: UM LEVANTAMENTO DE PESQUISAS HISTORIOGRÁFICAS NO BRASIL
Authors: Carneiro Rogerio dos Santos , Wielewski Gladys Denise , Pinto Neuza Bertoni
Published: April 2020

Neste artigo trazemos para debate uma análise realizada em dissertações e teses produzidas entre os anos de 2007 e 2017, as quais trouxeram colaborações importantes para a compreensão do desenvolvimento da Aritmética Escolar no Brasil, em especial na região amazônica. Pesquisas que foram desenvolvidas no âmbito da História da Educação Matemática, e tiveram um aporte teórico-metodológico da História Cultural, para analisar diferentes fontes documentais, tais como: periódicos, relatórios, atas de reuniões, manuais, livros escolares, dentre tantas outras. Os trabalhos analisados foram selecionados do repositório de conteúdo digital das pesquisas de história da educação matemática, do GHEMAT, e do banco de teses e dissertações da CAPES. Das sete pesquisas analisadas apenas uma investigou o desenvolvimento da Educação Matemática no Estado do Amazonas e, consequentemente, trouxe à luz os materiais didáticos que circularam no período de 1840 a 1946, as demais abordam desenvolvimento da Aritmética Escolar no Brasil, de forma geral, e alguns até superficialmente, por não ser o tema das referidas pesquisas.
Walking toward ipsas adoption: a discussion about brazilian public sector changes under the perspective of institutional theory
Authors: Araújo João Gabriel Nascimento de , Souza Fernando Gentil de
Published: April 2020

Este estudo tem como objetivo examinar as influências de forças institucionais no processo de convergência em contabilidade governamental no Brasil. Além da introdução, a segunda seção descreve a adoção das IPSAS no Brasil. Na terceira parte, abordamos, do ponto de vista da teoria institucional do NIS, específico das pressões miméticas, normativas e coercitivas, esse processo de mudança na contabilidade do governo brasileiro; e, finalmente, fizemos algumas considerações finais sobre o assunto. Discutimos alguns casos reais do contexto brasileiro sobre a adoção das IPSAS, com base em observação direta, várias entrevistas informais com diferentes agentes do setor público brasileiro em diferentes níveis e várias instituições e revisão de literatura. É importante ressaltar que os exemplos mostrados aqui não são e não pretendem estar esgotados, mas apenas ilustrativos. Nossa intenção é fomentar o debate e esclarecer algumas pressões institucionais que existem nesse processo. Sugerimos como próximos passos o exame de fatores qualitativos, tais como: a qualidade das demonstrações contábeis; impacto em práticas de gerenciamento mais amplas (são orçamentos baseados em acréscimos, uso do balanço patrimonial para informar a tomada de decisão, etc.); e se as partes interessadas externas (cidadãos, membros eleitos, grupos sociais etc.) consideram que a introdução das IPSAS melhorou a prestação de contas
Modelos de gestão: uma revisão da literatura brasileira
Authors: Lugoboni Leonardo Fabris , Santos Bruno De Souza , Machado Eduardo Carcelen , Gomes Jésus De Lisboa
Published: April 2020

Esta pesquisa buscou compreender como os modelos de gestão estão sendo abordados pela literatura, qual o conteúdo e estrutura dessas pesquisas e possíveis tendências decorrentes ao modelo de gestão aplicado. Para isso, foram consultadas nas bases Spell e Scielo trabalhos que abordavam modelos de gestão, tanto centralizados como descentralizados. Ao todo foram identificados 152 trabalhos à base Spell e 269 trabalhos à Scielo, num total de 421 trabalhos. Destes 50 trabalhos foram usados a condução desta pesquisa.  Foi possível observar um crescimento nos trabalhos que abordam modelos de gestão. Variáveis como Gestão / Gestão de Pessoas, Organização, Estrutura, Poder e Responsabilidade e Coordenação têm-se mostrado como as variáveis mais presentes. Foi possível observar também uma provável uma tendência de crescimento relacionada ao estudo de modelos descentralizados. Espera-se com essa pesquisa contribuir para uma maior visualização das pesquisas relacionadas à modelos de gestão assim como as perspectivas futuras de pesquisa que pode ser adotadas ou evitadas pelos próximos pesquisadores.
Evaluación del tiempo en la recuperación de larvas de nematodos a partir de un coprocultivo
Authors: Leandro-Picado Andrea María , Calderón-Sancho Alexander , Alfaro-Mora Ramsés
Published: April 2020

Las infecciones producidas por nematodos gastrointestinales representan un problema de gran importancia para la salud en bovinos, además de afectar la economía de los ganaderos e industrias productoras. Se simuló las condiciones necesarias para el desarrollo de los huevos de los nematodos contenidos en las heces del bovino a través de un coprocultivo en aserrín de laurel (Laurus nobilis). En esta investigación se pretendió evaluar diferencias en el tiempo de recuperación de larvas de nematodos a partir del coprocultivo. En la metodología se realizó la técnica de flotación para la identificación de huevos de nematodos y el McMaster para contabilizar la cantidad de huevos por gramo de heces y la cantidad de larvas recuperadas del coprocultivo a los diferentes tiempos. El análisis de los resultados se realizó con el software Minitab versión 19, y se aplicó un ANOVA con un análisis post hoc de Tukey. Como resultado, se estableció que existe una diferencia significativa, de importancia, en el conteo de nematodos cuando estos se recolectan a las 3 horas.
¿Masculinidades en el sector mercantil? Trabajo y género en una empresa multinacional de supermercados en la ciudad de Rosario, Argentina
Authors: Guiamet Jaime
Published: April 2020

El presente artículo analiza las formas en que se construye la masculinidad en una empresa multinacional de supermercados en la ciudad de Rosario, Argentina. Este trabajo forma parte de una investigación más amplia plasmada en nuestra tesis doctoral acerca de las experiencias laborales de jóvenes trabajadores de supermercados. La metodología aplicada consistió en un enfoque antropológico, cuyas herramientas principales fueron entrevistas en profundidad y observación participante. Analizaremos las experiencias de los trabajadores en torno a tres aspectos en particular: los sentidos sobre el esfuerzo físico en la reposición de productos; la importancia de los sectores de reposición y de producción de alimentos perecederos como sectores “masculinos” y “adultos” y los procesos de estigmatización de lo femenino manifiesto en concepciones sobre el trabajo de las cajeras.
Enhancing Learning for Early Years Foundation Degree Students: Empowerment through Heutagogy and Reflecting on the Notion of Knowledgeable Others
Authors: Teszenyi Eleonora , Devecchi Cristina , Richardson Tanya
Published: April 2020

This paper reports on a small-scale practitioner enquiry undertaken with 17 work-based learners studying on a two-year Early Years Foundation Degree programme in a higher education institution in England. The first aim of the enquiry was to identify the perspectives of a cohort of work-based Early Years Foundation Degree students on teaching strategies they experienced at a higher education institution in the English midlands. The second aim was to identify how the findings could be applied to curricular and andragogic enhancements for future students. Beliefs and attitudes questionnaires were administered to the students half way through their programme. Findings indicate that students valued strategies that included the direct input of the lecturers they regarded as ‘more knowledgeable others’ (Vygotsky, 1978), yet they rated peer support as less effective for their learning. Findings indicate that early years students’ applications of learned theory to work-based practice may need to go beyond a singular notion of ‘communities of practice’ (Lave & Wenger, 1991). Although these students are positioned and position themselves as more knowledgeable others in their own workplace communities, they regard themselves as lacking knowledge in their higher education community. As members of these various communities, they straddle heutagogic and andragogic approaches in their respective communities of practice. In recognition of this, the paper argues that not only should higher education lecturers working with work-based students adopt andragogic strategies but they should also promote heutagogic approaches that increase student autonomy. They should also communicate explicitly to their students the value of such strategies for learning in the field, both in theory and practice.
The Fe Analysis and Variation of Composite Top Hat Shaped Beam
Authors: David Petr , Padovec Zdeněk , Zámečníková Tereza , Sedláček Radek
Published: April 2020

The main goal of this work is to provide a composite alternative to an already existing beam which has top hat cross section. The main part of this work is focused on using the finite element method to solve the problem. Firstly, a duralumin version will be used to calibrate the computation, then the problem will be solved for different options of slightly adjusted geometry. The computation itself will include general static analysis as well as analysis of buckling.
Sensitive Analysis on Selection of Piston Material Using MADM Techniques
Authors: Chaitanya K Lakshmi , Srinivas Kolla
Published: April 2020

Decision making in material selection plays important role in selecting appropriate material based on design and manufacturing attributes. Proposing a new material is always a challenging task so the researchers used Decision making assistance tools. In the Present paper the application of Multi-Attribute Decision Making (MADM) methods are applied to the piston material selection for optimal design process. Comparative study of subjective and objective criteria weights on selected MADM methods are done. Sensitivity analysis is conducted to prove the consistency in performance score ranking order as the criteria weights for each alternative varies.
Dynamic Image Analysis to Determine Granule Size and Shape, for Selected High Shear Granulation Process Parameters
Authors: Oliver Macho , Matúš Čierny , Ľudmila Gabrišová , Martin Juriga , Radovan Ružinský , Peter Peciar
Published: April 2020

The aim of this study was to investigate the usage of Dynamic Image Analysis for determination of size, shape and distribution of granules of microcrystalline cellulose, created by high shear granulation. A series of experiments was carried out to analyse the effect of process parameters on a created granule morphology. The amount of the granulation liquid and speed of the impeller have a significant effect on the median size granule value, the sphericity, the granule distribution width, but also on the granulation process yield.
Grey-WPCA Based Parametric-Optimization and Modelling of Chromium Powder Mixed Surface-Electro Discharge Diamond Grinding of Inconel 600 Using RSM
Authors: Modi Manoj , Agarwal Gopal , Chaugaonkar Swati D
Published: April 2020

The PMS-EDDG is an effective hybrid process to beat the problems identified in machining of Inconel 600 through the conventional machining process. This hybrid-machining-process is a combination of SDG and Powder Mixed-EDM process. Modeling, comparative investigation, determination of optimal setting of process factors, and various surface developments in S-EDDG of Inconel 600 with chromium and absence of chromium-powder blended dielectric fluid (DF) have been narrated in this research work. One set of 31 experiments with chromium-powder and another set of 31 experiments without chromium-powder mixed DF was conducted on this set-up in accordance with the C-C-R-D plan of experimentation. The developed models through RSM support to investigate the behavior of input process-factors over the responses. The input factors in this research work are ampere-current (I), pulse-on-time (Ton), wheel speed (WS), and duty cycle (DC). The MRR and Ra are the output-responses in this machining process. The optimum setting of process-parameters is computed through the integrated Grey-Taguchi based WPCA-approach. The confirmation experiment is conducted on this set-up at the optimum-condition and its results display the agreeable matching among the actual and predicted values. The WMPI is improved by 0.414. The SEM investigation has been conducted at the optimum-condition on the produced machined-surfaces and on the produced white recast-layer thickness.
Digital financial assets as an object of accounting: Debating points
Authors: Suprunova E.A.
Published: April 2020

Subject. This article discusses the issues related to the valuation of digital financial assets, their reflection on accounts and the relevant balance sheet item classification.
Objectives. The article aims to identify the main areas of digital financial asset accounting development in the context of ongoing changes in Russian law, and assess if there is any possibility to use foreign practices in digital financial assets accounting.
Methods. For the study, I used the methods of classification, analogy, comparison, logical research, and relevant scientific literature generalization.
Results. The article provides a comparative characterization of possible options for categorizing digital financial assets as certain items of asset, as well as arguments in favor of or against the choice of an asset. It offers standard accounting transactions to reflect digital financial assets in accounts based on their channels of origin. The article also assesses the possibility of applying international practices of digital financial assets accounting.
Conclusions and Relevance. Practical application of the results of the study is possible if the appropriate legislative framework is formed, which could determine the structure of regulation of different types of digital financial assets. The findings and conclusions presented in the article can be used by the scientific and business communities for further polemic. The results of the study are of a scientific nature and can be used in teaching the Accounting course.
Management of small business development in the region
Authors: Pronyaeva L.I. , Fedotenkova O.A.
Published: April 2020

Subject. This article discusses the economic relations and institutional and managerial processes in the sphere of State regulation of small business development at the regional level.
Objectives. The article aims to develop recommendations on improvement of the management system and strengthening of State influence in the sphere of small business development in the region.
Methods. For the study, we used the economic and statistical methods, graphic and expert estimate techniques, and the literature review approach.
Results. The article summarizes the experience of small business operations in foreign countries and assesses the developments of Russian economists dealing with small businesses and regional development. It defines the factors constraining the development of small business in the region and shows the main areas of its support by the State. To conduct a comprehensive assessment of small business development in the region, the article offers an original scorecard.
Conclusions. Implementing the proposed recommendations will help assess the condition of small business and apply appropriate tools in the system of State management of small business development in regions.
Retrospective analysis of energy sanctions against Russia and their impact on operations of pipe-rolling plants
Authors: Malyutina T.D.
Published: April 2020

Subject. The article focuses on sanctions against Russia’s energy sector.
Objectives. The article represents my own comprehensive study into sanctions against Russia’s energy sector and their impact on operations of pipe-rolling plants. The study spotlights the most significant milestones of the oil and gas industry, analyzes the sectoral impact on the development of pipe-rolling plants and pressure of the war against pipelines on the Russian manufacturers.
Methods. The study employs methods of comparison, research, monographs and logic.
Results. What distinguishes the Russian pipe-rolling plants is their importance for operations of oil and gas producing sectors. Based on the retrospective analysis of energy sanctions against Russia, I conclude that tensions in economic relations of European countries, and the USA and Russia last too long. Energy sanctions definitely influence operations of pipe-rolling plants. Export barriers obstructed the influx of investment into the respective sector and affected the financial performance of enterprises. However, a drop in exports of pipe-rolling plants’ products fuels their domestic distribution plans, thus contributing to the positive economic situation nationwide.
Conclusions and Relevance. Economic sanctions will influence the development of the Russian oil and gas companies in the distant future, since the Russian enterprises manufacture high-tech products insufficiently, while supplies from China are not yet reliable. Sanctions against Russia trigger the development of the Russian enterprises manufacturing high-tech products and large diameter pipes for the oil and gas industry.
Effects of dexmedetomidine and esmolol on otoacoustic emissions during controlled hypotensive anesthesia: randomized clinical trial
Authors: Gökahmetoğlu Günhan , Pehlivan Sibel , Aksu Recep , Biçer Cihangir
Published: April 2020

Purpose: The aim of this study was to investigate the ability of esmolol and dexmedetomidine to achieve controlled hypotension on cochlea by measuring otoacoustic emission and stapedius reflex.

Methods: In this prospective, double-blind pilot study, patients scheduled for elective tympanoplasty, rhinoplasty and endoscopic sinus surgery operation were randomly assigned to two groups, and received either dexmedetomidine (n=23) or esmolol (n=24) during surgery to maintain a mean arterial blood pressure between 55 and 65 mmHg. Distortion product otoacoustic emission tests (DPOAE) were performed 24 hours before and after the operation and during surgery (in the 20th and 40th minutes of the operation).

Results: In the intra-group comparison, a statistically significant decrease was present at t20 (2,000 and 4,000 Hz frequency band) and t40 (1,000 and 1,500 Hz) according to the baseline value in the dexmedetomidine group (n=23); in the esmolol group (n=24), a statistically significant decrease (relative to the baseline value) was also detected at t20 and t40 for the 1,000 Hz frequency band. No damage was found on stapes reflexes with the infusion of these drugs.

Conclusions: Infusion of dexmedetomidine and esmolol decreased DPOAE levels during the operations, but DPOAE levels returned to normal in the postoperative period, and had no effect on stapes reflexes. Studies with larger groups of patients are needed to confirm these results in tympanoplasty and other surgeries.
Newsletter Spring 2020: Clinician Investigator Trainee Association of Canada (CITAC)
Authors: Marvasti Tina B. , Pietrobon Adam
Published: April 2020

Message from Tina Marvasti, President of the Clinician Investigator Trainee Association of Canada: National and international collaborations and evidence based advocacy for the Canadian MD/PhD and MD+ trainees

The overarching goals of the Clinician Investigator Trainee Association of Canada (CITAC) for 2020 are to expand its reach to increase membership and to continue to build strong relationships with our national and international partners. These goals will be achieved by applying the following three strategies:

Continue to develop and strengthen our relationships with national and international key partners and with stake holders

Better understand the needs of clinician-scientist trainees for evidence-based advocacy

Increase membership, improve communication with all members and highlight the

accomplishments of trainees
Teaching practice in teachers’ initial training in Cape Verde: supervisors’ perspectives
Authors: Lima Isabel Salomé de Miranda Santos de , Andrade Ana Isabel , Costa Nilza Maria Vilhena Nunes da
Published: April 2020

This article aims to characterize the supervisors’ discourse about their TP in the context of initial teacher education of future Secondary School teachers in Cape Verde, trying to understand some of their limitations and/or failures while performing their academical duties and, consequently, their training needs. The methodology involves construction, validation, and application of questionnaires with 10 institutional supervisors, 19 cooperative supervisors and 66 future teachers, and in order to better understand the results interviews with 3 Higher Education supervisors and 3 school supervisors were carried out. The results show that it is urgent to develop supervisors’ competences, in order to promote reflexive and critical teachers, based on thinking and acting, as well as to increase collaboration with their peers, in a reflective scenario of teacher education. This will certainly enhance the quality of their supervisor role, and make them more active in their professional development, profile of trainees and, consequently, education in the archipelago, at large
Petty crime: quo vadis?
Authors: Suponina Elena Aleksandrovna , Dolgikh Igor' Petrovich
Published: April 2020

The subject of this research is the normative gaps that have been an intrinsic part of petty crime for many years. Among most discussible within the academic community problems related to such legal violation, the author selected the following: absence of legal definition of the concept of obscenities in the national legislation; complexity of delimitation of petty crime from the adjacent administrative and criminal offences; disaccord in interpretation of the concept of “public place”. Particular attention is paid to the prospects of optimization of administrative-legal norms established in the Article 20.1 of the Code of Administrative Offences of the Russian Federation. The main conclusion of the conducted research lies in the statement that from the perspective of legal technique, the article 20.1 of the Code of Administrative Offences of the Russian Federation is in a permanent motion. However, this motion is chaotic and inconsequential. The introduced amendments to the text of codified law did not enhanced the protection of public order, as well as created the additional difficulties for the law enforcer. This article makes an attempt of systemic analysis of provisions of the Federal Law No.28-FZ of 03.18.2019 that complemented the article 20.1 of the Code of Administrative Offences of the Russian Federation with the Sections 3-5.
The influence of water in the synthesis of Zr-based metal-organic framework UiO-66: isolation and reactivity of the new species [ZrCl(OH)2(DMF)2]Cl
Authors: Taddei Marco , A. van Bokhoven Jeroen , Ranocchiari Marco
Published: April 2020

We recently discovered that aging a solution of zirconium(IV) tetrachloride (ZrCl4) in N,N-dimethylformamide (DMF) in the presence of water, followed by addition of terephthalic acid linker, reduces the crystallite size of the metal-organic framework UiO-66 [Chem. Commun. 2016, 52, 6411-6414]. In an effort to shed light into the nature of the aging effect and on its relationship with the crystallite size of UiO-66, we report here the isolation and structural characterization of a microcrystalline zirconium-based compound of formula [ZrCl(OH)2(DMF)2]Cl, which is formed during the aging process. The Zr(IV) ions are coordinated by hydroxide, DMF and chloride to produce a one-dimensional polymer. Thanks to the presence of two –OH groups per zirconium atom, [ZrCl(OH)2(DMF)2]Cl is a suitable precursor for the synthesis of UiO-66 in dry DMF, affording a product having smaller crystallite size than that obtained from a reaction mixture having the same chemical composition, but using ZrCl4 as the Zr(IV) source. By starting from ZrCl4 and generating [ZrCl(OH)2(DMF)2]Cl in situ in solution through aging, we obtained smaller crystallites as the aging time increased, proving that [ZrCl(OH)2(DMF)2]Cl plays a role in the aging process. The possible role of [ZrCl(OH)2(DMF)2]Cl in the crystallization mechanism of UiO-66 is also discussed, with emphasis on its relationship with the amount of water in the reaction mixture.
Expedient Method for Direct Mono-amidation of Phosphonic and Phosphoric Acids
Authors: Yan Victoria , Pham Cong-Dat , Muller Florian
Published: April 2020

Mono-amidated P(V) pro-drugs predominately contribute to the vastly improved delivery of phosphate and phosphonate-containing anti-viral/cancer nucleotide analogues. However, synthetic approaches towards their formation are often harsh and unreliable, which may hamper the identification of novel, more effective amine pro-drugs. Here, we show that direct mono-amidation of structurally complex phosphonic and phosphoric acids may be accomplished in as quickly as seconds by re-purposing the PPh3/DIAD redox pair. Where the triphenylphosphine oxide byproduct is often cited as a vulnerability, we use its formation as an asset. Juxtaposing the anionic nature of the generated mono-amidated product, the desired product may be isolated with a single water extraction. Compared to state-of-the-art strategies towards phosphoramidates, our approach is mild, reliable, and enables access to a variety of aliphatic and benzylic amines for pro-drug attachment.
General Cluster Sorption Isotherm
Authors: Buttersack Christoph
Published: April 2020

Adsorption isotherms are an essential tool in chemical physics of surfaces. However, several approaches based on a different theoretical basis exist and for isotherms including capillary condensation existing approaches can fail. Here, a general isotherm equation is derived and applied to literature data both concerning type IV isotherms of argon and nitrogen in ordered mesoporous silica, and type II isotherms of disordered macroporous silica. The new isotherm covers the full range of partial pressure (10-6 - 0.7). It relies firstly on the classical thermodynamics of cluster formation, secondly on a relationship defining the free energy during the increase of the cluster size. That equation replaces the Lennard-Jones potentials used in the classical density functional theory. The determination of surface areas is not possible by this isotherm because the cross-sectional area of a cluster is unknown. Based on the full description of type IV isotherms, most known isotherms are accessible by respective simplifications.
Dinuclear Complexes of Flexidentate Pyridine-Substituted Formazanate Ligands
Authors: Mu Ge , Teets Thomas
Published: April 2020

In this work we show the utility of flexidentate pyridyl‐substituted formazanate ligands in assembling dinuclear coordinationcomplexes with iridium(III) and/or platinum(II) building blocks. The versatile binding modes of these ligands allow the preparation of several different dinuclear structures, highlighting the potential of these formazanates to serve as redoxactive supporting ligands for multimetallic complexes. The dinuclear complexes are typically prepared in a stepwise strategy, adding one metal unit at a time, with the coordination mode of the formazanate with the first metal dictating the binding mode in the final dinuclear structure. Eight of the new complexes, including both mononuclear precursors and dinuclear products, are structurally characterized by single‐crystal X‐ray diffraction, which along with NMR spectroscopy unambiguously establish ligand binding modes and symmetries of the compounds. All complexes are characterized by UVVis absorption spectroscopy and cyclic voltammetry. The frontier orbitals are localized on the formazanate ligand, and a characteristic, intense formazanate‐centered π→π* absorption band is observed in the absorption spectrum. Structureproperty relationships are established, relating the ligand binding mode to the redox properties and spectroscopic features. .
On the Basis Set Selection for Calculations of Core-Level States: Different Strategies to Balance Cost and Accuracy
Authors: Sarangi Ronit , Vidal Marta L. , Coriani Sonia , Krylov Anna
Published: April 2020

We present a study on basis set effect in correlated calculations of core-level states. While it is well recognized that the core-level states require using more extensive basis sets than their valence counterparts, the standard strategy has been to use large contracted basis sets, such as the cc-pVXZ or cc-pCXZ series. Building upon the ideas of Besley, Gilbert, and Gill [J. Chem. Phys. 130, 124308 (2009)], we show that much more effective strategy is to use uncontracted bases, such as core or fully uncontracted Pople's basis. The physical grounds behind this approach are explained and illustrated by numerical results. We also discuss other cost-saving strategies, such as virtual space truncation and using mixed precision execution.
Controlling Intramolecular Interactions in the Design of Selective, High-Affinity, Ligands for the CREBBP Bromodomain
Authors: Brand Michael , Clayton James , Moroglu Mustafa , Schiedel Matthias , Picaud Sarah , Bluck Joseph , Skwarska Anna , Chan Anthony , Laurin Corentine , Scorah Amy , See Larissa , Rooney Timothy , Fedorov Oleg , Perell Gabriella , Kalra Prakriti , Cortopassi Wilian , Christensen Kirsten , Cooper Richard , Paton Robert , Pomerantz William , Biggin Philip , Hammond Ester M. , Filippakopoulos Panagis , Conway Stuart
Published: April 2020

CREBBP (CBP or KAT3A) and its paralogue P300 (also KAT3B) are lysine acetyltransferases (KATs) that are essential for human development. They each comprise ten domains through which they interact with over 400 proteins, making them important transcriptional co-activators, and key nodes in the human protein-protein interactome. The bromodomain of CREBBP and P300 enables binding of acetylated lysine residues from histones, and a number of other important proteins, including p53, p73, E2F and GATA1. Here we report work to develop a high affinity, small molecule, ligand for the CREBBP and P300 bromodomains [(−)-OXFBD05] that shows >100-fold selectivity over the BET bromodomains. Key to the development of (−)-OXFBD05 were fundamental studies on molecular conformation in solution and when bound to the CREBBP bromodomain. In particular, the effect of an intramolecular hydrogen bond on solution state conformation, and use of an amide bioisostere, enabled the development of (−)-OXFBD05. Initial cellular studies using this ligand demonstrate that inhibition of the CREBBP/P300 bromodomain in HCT116 colon cancer cells results in lowered levels of c-Myc, and a modest but repeatable reduction in H3K18 acetylation. In hypoxia (<0.1% O2), inhibition of the CREBBP/P300 bromodomain results in enhanced stabilization of HIF-1α. This presents an opportunity for modulating proteins that are affected by HIF-1α levels, including ACE2, which mediates SARS-CoV-2 infection of human cells.
Discovery of New Hydroxyethylamine Analogs Against 3CLpro Protein Target of SARS-CoV-2: Molecular Docking, Molecular Dynamics Simulation and Structure-Activity Relationship Studies
Authors: Kumar Sumit , Sharma Prem Prakash , Shankar Uma , Kumar Dhruv , Joshi Sanjeev K , Pena Lindomar , Durvasula Ravi , Kumar Amit , Kempaiah Prakasha , . Poonam , Rathi Brijesh
Published: April 2020

A novel coronavirus, SARS-CoV-2 has caused a recent pandemic called COVID-19 and a severe health threat around the world. In the current situation, the virus is rapidly spreading worldwide, and the discovery of vaccine and potential therapeutics are critically essential. The crystal structure for main protease (Mpro) of SARS-CoV-2, 3-chymotrypsin-like cysteine protease (3CLpro) was recently made available and is considerably similar to previously reported SARS-CoV. Due to its essentiality in viral replication, it represents a potential drug target. Herein, computer-aided drug design (CADD) approach was implemented for the initial screening of 13 approved antiviral drugs. Molecular docking of 13 antivirals against 3-chymotrypsin-like cysteine protease (3CLpro) enzyme was accomplished and indinavir was described as a lead drug with a docking score of -8.824 and a XP Gscore of -9.466 kcal/mol. Indinavir possesses an important pharmacophore, hydroxyethylamine (HEA), and thus a new library of HEA compounds (>2500) was subjected to virtual screening that led to 25 hits with a docking score more than indinavir. Exclusively, compound 16 with docking score of -8.955 adhered to drug like parameters, and the Structure-Activity Relationship (SAR) analysis was demonstrated to highlight the importance of chemical scaffolds therein. Molecular Dynamics (MD) simulation studies carried out at 100ns supported the stability of 16 within the binding pocket. Largly, our results supported that this novel compound 16 binds to the domain I & II, and domain II-III linker of 3CLpro protein, suggesting its suitablity as strong candidate for therapeutic discovery against COVID-19. Lead compound 16 could pave incredible directions for the design of novel 3CLpro inhibitors and ultimately therapeutics against COVID-19 disease.
Compilation of Potential Protein Targets for SARS-CoV-2: Preparation of Homology Model and Active Site Determination for Future Rational Antiviral Design
Authors: Pal Sourav , Talukdar Dr. Arindam
Published: April 2020

The recent pandemic due to the novel coronavirus SARS-CoV-2 (COVID-19) is causing significant mortality worldwide. However, there is a lack of specific drugs which can either prevent or treat the patient suffering from COVID-19. To understand the SARS-CoV-2 receptor recognition causing infectivity and pathogenesis, we have compiled a list of 20 probable drug targets on host and virus based on viral life cycle along with their PDB IDs for the rational development of future antivirals. We have prepared nine homology model for vital proteins for which no crystal structure is reported, which includes protein from host, viral membrane proteins and essential non-structural proteins (NSPs) of virus. The generated models were validated followed by Ramachandran plot along with their sequence and structural alignment. The active site residues of all the protein models are calculated by utilizing COACH meta-server and also cross verified with the CASTp webservers. All the active sites of the homology build proteins were evaluated after superimposition of the closely related X-ray crystallized structure bound with the co-crystal ligands. These information present in the manuscript can be used for the discovery effort towards new antivirals as well as repurposing FDA approved drugs against SARS-CoV-2.
Combination of fast hybrid classification and k value optimization in k-nn for video face recognition
Authors: Septiana Nuning , Suciati Nanik
Published: April 2020

Nowadays, the need for face recognition is no longer include images only but also videos. However, there are some challenges associated with the addition of this new technique such as how to determine the right pre-processing, feature extraction, and classification methods to obtain excellent performance. Although nowadays the k-Nearest Neighbor (k-NN) is widely used, high computational costs due to numerous features of the dataset and large amount of training data makes adequate processing difficult. Several studies have been conducted to improve the performance of k-NN using the FHC (Fast Hybrid Classification) method by optimizing the local k values. One of the disadvantages of the FHC Method is that the k value used is still in the default form. Therefore, this research proposes the use of k-NN value optimization methods in FHC, thereby, increasing its accuracy. The Fast Hybrid Classification which combines the k-means clustering with k-NN, groups the training data into several prototypes called TLDS (Two Level Data Structure). Furthermore, two classification levels are applied to label test data, with the first used to determine the n number of prototypes with the same class in the test data. The second classification using the optimized k value in the k-NN method, is employed to sharpen the accuracy, when the same number of prototypes does not reach n. The evaluation results show that this method provides 86% accuracy and time performance of 3.3 seconds.