bluuebunny/crossref_metadata_2025 huggingface dataset:
Autumn de-worming in adult horses
Authors: Rendle David
Published: November 2017

Autumn is traditionally a time when all horses are de-wormed with a product that is effective against tapeworms and both adult and larval roundworms. However, if management is good and appropriate testing has been performed for the presence of round and tapeworms, there may be no need to use anthelmintics. For tapeworms, a single test for antibodies to Anoplocephala spp.provides reassurance that treatment is not necessary. For roundworms the situation is more complicated as there is no test for larval stages currently. There is therefore a reliance on repeated worm egg counts through the grazing season. The risk of exposure, albeit low, to large strongyles also needs to be considered.
Ehrlichia canis (Rickettsiales: Anaplasmataceae) en garrapatas Rhipicephalus sanguineus sensu lato del linaje templado (Acari. Ixodidae), provincia de Buenos Aires, Argentina
Authors: CICUTTIN Gabriel , DE SALVO María N. , SILVA Darío , BRITO Mariana , NAVA Santiago
Published: November 2017

El objetivo del presente estudio es notificar el hallazgo de Ehrlichia canis en garrapatas Rhipicephalus sanguineus sensu lato (s. l.) del linaje templado (LTe) colectadas sobre un canino con ehrlichiosis monocítica canina de José C. Paz (zona noroeste del Área Metropolitana de Buenos Aires –AMBA-). Se colectaron 32 garrapatas, siendo determinadas taxonómicamente como R. sanguineus s. l. (30 larvas y 2 ninfas). Mediante una PCR inicial para la familia Anaplasmataceae para un fragmento del gen ARNr 16S, resultaron positivas un grupo de 10 larvas y una ninfa. Dichas muestras positivas también fueron amplificadas mediante una PCR para un fragmento del gen dsb del género Ehrlichia, y posteriormente secuenciadas, resultando en un 100% de identidad con E. canis. Los especímenes de R. sanguineus s.l. positivos para E. canis fueron estudiados mediante una PCR para del gen mitocondrial 16S de garrapatas del grupo Metastriata, demostrándose su pertenencia al linaje templado de R. sanguineus s. l. Los estudios experimentales y los antecedentes epidemiológicos relacionan E. canis con R. sanguineus s. l. del linaje tropical, pero considerando que el único linaje de R. sanguineus detectado en AMBA ha sido el LTe, es necesario continuar investigando para dilucidar el mecanismo de transmisión y la dinámica vectorial en esta área.
Arte, conflicto, solución
Authors: Muñoz Gómez Jesús Holmes
Published: November 2017

Solución: es un concepto que surge de un conflicto , en la interrelación entre conflicto y solución ha tenido lugar el despliegue del saber humano. La solución fluye desde la ejecución y puesta en marcha de un procedimiento con miras hacia una verdad . Ahora bien, al comprender el conflicto como un estado en el que oscilan dos posibilidades adversas que alteran la proyección u horizonte de algún objetivo, tiene cabida el arte como una importante posibilidad que abre el camino a un sinnúmero de formas procedimentales, transversales y sensibles del ser humano sobre el mundo. Así, desde la perspectiva de Joseph Beuys, por ejemplo, adviene la figura del chaman y su espiritualidad curativa, su intervención ritual por y sobre los conflictos; el curar se define como sinónimo de purificación, de selección y de evidencia de algo para su respectiva solución; en los saberes otros, enunciados desde la visión de algunos médicos tradicionales, sanar es cerrar heridas, borrar huellas por medio del saber, del sentir y del hacer; se trata de desvanecer ciertos conflictos que desarmonizan el el andar humano por el mundo.
Score Distributions of the Balance Outcome Measure for Elder Rehabilitation (BOOMER) in Community-Dwelling Older Adults With Vertebral Fracture
Authors: Brown Zachary M. , Gibbs Jenna C. , Adachi Jonathan D. , Ashe Maureen C. , Hill Keith D. , Kendler David L. , Khan Aliya , Papaioannou Alexandra , Prasad Sadhana , Wark John D. , Giangregorio Lora M.
Published: November 2017

Background and Purpose:

We sought to evaluate the Balance Outcome Measure for Elder Rehabilitation (BOOMER) in community-dwelling women 65 years and older with vertebral fracture and to describe score distributions and potential ceiling and floor effects.

Methods:

This was a secondary data analysis of baseline data from the Build Better Bones with Exercise randomized controlled trial using the BOOMER. A total of 141 women with osteoporosis and radiographically confirmed vertebral fracture were included. Concurrent validity and internal consistency were assessed in comparison to the Short Physical Performance Battery (SPPB). Normality and ceiling/floor effects of total BOOMER scores and component test items were also assessed. Exploratory analyses of assistive aid use and falls history were performed.

Results and Discussion:

Tests for concurrent validity demonstrated moderate correlation between total BOOMER and SPPB scores. The BOOMER component tests showed modest internal consistency. Substantial ceiling effect and nonnormal score distributions were present among overall sample and those not using assistive aids for total BOOMER scores, although scores were normally distributed for those using assistive aids. The static standing with eyes closed test demonstrated the greatest ceiling effects of the component tests, with 92% of participants achieving a maximal score.

Conclusions:

While the BOOMER compares well with the SPPB in community-dwelling women with vertebral fractures, researchers or clinicians considering using the BOOMER in similar or higher-functioning populations should be aware of the potential for ceiling effects.
Urinary Tract Infection Antibiotic Trial Study Design: A Systematic Review
Authors: Basmaci Romain , Vazouras Konstantinos , Bielicki Julia , Folgori Laura , Hsia Yingfen , Zaoutis Theoklis , Sharland Mike
Published: November 2017

CONTEXT:

Urinary tract infections (UTIs) represent common bacterial infections in children. No guidance on the conduct of pediatric febrile UTI clinical trials (CTs) exist.

OBJECTIVE:

To assess the criteria used for patient selection and the efficacy end points in febrile pediatric UTI CTs.

DATA SOURCES:

Medline, Embase, Cochrane central databases, and clinicaltrials.gov were searched between January 1, 1990, and November 24, 2016.

STUDY SELECTION:

We combined Medical Subject Headings terms and free-text terms for “urinary tract infections” and “therapeutics” and “clinical trials” in children (0–18 years), identifying 3086 articles.

DATA EXTRACTION:

Two independent reviewers assessed study quality and performed data extraction.

RESULTS:

We included 40 CTs in which a total of 4381 cases of pediatric UTIs were investigated. Positive urine culture results and fever were the most common inclusion criteria (93% and 78%, respectively). Urine sampling method, pyuria, and colony thresholds were highly variable. Clinical and microbiological end points were assessed in 88% and 93% of the studies, respectively. Timing for end point assessment was highly variable, and only 3 studies (17%) out of the 18 performed after the Food and Drug Administration 1998 guidance publication assessed primary and secondary end points consistently with this guidance.

LIMITATIONS:

Our limitations included a mixed population of healthy children and children with an underlying condition. In 6 trials, researchers studied a subgroup of patients with afebrile UTI.

CONCLUSIONS:

We observed a wide variability in the microbiological inclusion criteria and the timing for end point assessment. The available guidance for adults appear not to be used by pediatricians and do not seem applicable to the childhood UTI. A harmonized design for pediatric UTIs CT is necessary.
Az arteria thoracodorsalis perforátor fasciocutan lebeny a krónikus axillaris hidradenitis suppurativa kezelésében
Authors: Mohos Balázs , Sándor Gábor , Bognár Gábor , Csucska Máté , Lóderer Zoltán
Published: November 2017

Absztrakt:

Bevezetés: A krónikus hidradenitis suppurativa (HS) egyetlen
definitív, relapsusokat kiküszöbölő gyógymódja az érintett mirigyállomány teljes
eltávolítása. Az így keletkezett hiányt pótolni kell. A rekonstrukciót
leggyakrabban részvastag bőrrel (SSG) végzik, azonban az arteria thoracodorsalis
perforátor (TDAP) fasciocutan lebeny alkalmazásával kedvezőbb funkcionális és
esztétikai eredmény érhető el. Módszer: 2014. május és 2016.
július között 14 betegnél történt HS miatti excisio utáni helyreállítás, két
páciens esetében kétoldali. A rekonstrukció 15 alkalommal TDAP és egy esetben
arteria thoracodorsalis kapilláris perforátor (TAPcp) lebennyel történt.
Eredmények: A 16 lebeny közül kettő kivételével mindet egy
domináns perforátor látta el. Egy esetben két domináns perforátor, egy további
esetben kapilláris perforánsok látták el a lebenyt. A lebenyek mérete 6 × 8 és
10 × 15 cm között volt. 15 helyreállítás volt sikeres. Egy lebeny nekrotizált,
valószínűleg a beteg együttműködésének hiánya miatt.
Összefoglalás: Krónikus HS miatt végzett
mirigyállomány-excisiót követően hiány keletkezik. Ennek rekonstrukciójában a
TDAP-lebeny kiváló alternatívája az SSG által végzett helyreállításnak.
Minor psychiatric disorders and their associations in family caregivers of people with mental disorders
Authors: Treichel Carlos Alberto dos Santos , Jardim Vanda Maria da Rosa , Kantorski Luciane Prado , Neutzling Aline dos Santos , Oliveira Michele Mandagará de , Coimbra Valéria Cristina Christello
Published: November 2017

Abstract This study aims to analyze the occurrence of minor psychiatric disorder and their associations in relatives of people with mental disorders. This is a cross-sectional study of 1164 relatives. For the tracking of minor psychiatric disorders the Self-Reporting Questionnaire Scale (SRQ20) was used, adopting 6/8 as cut-off point. Bivariate analyzes were conducted using Chi-squared test. Trends among strata of independent variables were investigated in relation to the outcome using nonparametric linear trend test. Statistic significance was defined as p-value < 0.05. Crude and adjusted binary logistic regressions were conducted using as a basis the hierarchical model developed through a systematic literature review. It was observed in the population a prevalence of 46.9% for minor psychiatric disorders. Higher prevalence of minor psychiatric disorders were strongly associated with the female gender, older age, first degree family ties, not having a paid work, lower education level, lower income, health problems, lower quality of life and feeling of burden. Many factors are related to the emotional and mental illness of family caregivers, demanding health services to be prepared to recognize and intervene in these situations.
Benefício de Prestação Continuada (BPC) para pessoas com deficiência: barreiras de acesso e lacunas intersetoriais
Authors: Vaitsman Jeni , Lobato Lenaura de Vasconcelos Costa
Published: November 2017

Resumo A Constituição Federal de 1988 aprovou o Benefício de Prestação (BPC) para idosos e pessoas com deficiência com renda familiar até 1/4 do salário mínimo, que alcançou em 2015 cerca de 4 milhões de pessoas. Para pessoas com deficiência, a implementação do BPC envolve organizações da previdência social, assistência social e saúde. O trabalho discute como algumas lacunas nos mecanismos de coordenação intersetorial entre essas áreas produzem barreiras de acesso aos potenciais beneficiários. Os resultados são de pesquisa qualitativa realizada com médicos, técnicos administrativos e assistentes sociais do Instituto Nacional do Seguro Social (INSS) e dos Centro de Referência da Assistência Social (CRAS) em três municípios de diferentes regiões do país. A coordenação e a cooperação intersetoriais mais estruturadas ocorrem no nível federal. No nível local, dependem de iniciativas informais e horizontais, o que produz soluções imediatas, mas descontínuas. O papel dos CRAS permanece contingente na implementação. Ficou patente a necessidade de estabelecimento de mecanismos institucionalizados de coordenação e cooperação entre os setores da assistência social, saúde e previdência para melhorar a implementação e diminuir as barreiras de acesso ao BPC.
O BPC: dos avanços na seguridade aos riscos da reforma da previdência
Authors: Jaccoud Luciana de Barros , Mesquita Ana Cleusa Serra , Paiva Andrea Barreto de
Published: November 2017

Resumo Este artigo analisa as propostas de alteração no Benefício de Prestação Continuada (BPC) discutidas no âmbito da reforma previdenciária, tanto na original do governo de 2016 quanto no substitutivo apresentado pelo relator do projeto no Congresso em 2017. As mudanças aventadas incidem sobre dois aspectos: aumento na idade mínima de acesso e desvinculação do valor do benefício do salário mínimo. São discutidas no texto, as justificativas para a reforma do BPC, referentes tanto aos desestímulos à contribuição previdenciária como às mudanças demográficas, assim como são estimados possíveis impactos das alterações propostas. O estudo conclui que as medidas, se aprovadas, tendem a reduzir a cobertura e a ampliar a vulnerabilidade de renda de idosos e de pessoas com deficiência no país.
Influence of phenomenology and existentialism on Gestalt therapy
Authors: BORIS Georges Daniel Janja Bloc , MELO Anna Karynne , MOREIRA Virginia
Published: November 2017

Abstract The literature on the influence of phenomenology and existentialism on Gestalt therapy is controversial because its founders did not clarify its philosophical and epistemological foundations. However, we understand that various influences exerted on Perls and his collaborators during the development of the Gestalt therapy led to a phenomenological-existential approach. The possible influences of phenomenology and existentialism on Gestalt therapy are discussed based on literature review focusing on the influence of Gestalt psychology, through Goldstein, Laura Perls, and Goodman, and the approaches to the phenomenological ideas of Brentano, Husserl and Merleau-Ponty. Similarly, with regard to existentialism, we address the combination of Gestalt concepts with the philosophies of Kierkegaard, Nietzsche, Buber, and Sartre. It was concluded that the influence of phenomenology and existentialism on Gestalt therapy resulted in the conception of man as a being-in-the-world and an emphasis on past experiences.
Validity evidence of the Zulliger-CS in older adults with Parkinson’s disease
Authors: RIEN Margarete , SCORTEGAGNA Silvana Alba , GRAZZIOTIN Jucelaine Bier Di Domenico , BERTOLIN Telma Elita
Published: November 2017

Abstract The ethical principles of psychological assessment include the need to use reliable tests to meet the demands of the emerging population. Therefore, the present study sought to provide evidence of validity of the Zulliger Comprehensive System (Zulliger Test in the Comprehensive System) considering the constructs: self-perception and interpersonal relationships. A total of 61 older adults of both sexes participated in the study; 30 had Parkinson’s disease (clinical group) and 31 were healthy (non-clinical group). The clinical group showed an increase in the following variables: Human detail (p = 0.02, d = 0.50); Morbid responses (p = 0.025, d = 0.62); Vista responses (p = 0.016, d = 0.72), Food Responses (p = 0.021, d = 0.61) and Decrease in human detail fictional (p = 0.012, d = -0.65) and in Personalized Responses (p = 0.003, d = -0.48). There was a positive relationship between the Zulliger Test in the Comprehensive System variables and age, income, and disease severity and a negative relationship between the Zulliger Test in the Comprehensive System variables and time since diagnosis. The results obtained confirm the validity of the Zulliger Test in the Comprehensive System and encourage further studies.
Programa Universidade para Todos (PROUNI): efeitos financeiros em uma instituição de educação superior privada
Authors: Haas Celia Maria , Pardo Rosangela da Silva
Published: November 2017

O artigo apresenta os resultados de pesquisa finalizada em 2013, cujo propósito foi o de verificar se a isenção fiscal alcançada por uma Instituição de Educação Superior Privada com fins lucrativos, após adesão ao Programa Universidade para Todos (PROUNI), superou os investimentos em bolsas de estudos ofertadas pelo programa e, com isso, assegurou a continuidade ou, até mesmo, a expansão desta instituição no mercado educacional. A investigação, desenvolvida em duas etapas, teve, na primeira, um estudo dos documentos contábeis institucionais relativos ao Prouni. A entrevista com o mantenedor da instituição, na segunda etapa, foi realizada para qualificar as informações obtidas na análise dos documentos. Para compreensão dos dados, contou-se com as reflexões de autores que tratam do tema em estudo. Os resultados demonstraram que o ganho fiscal alcançado pela instituição, após sua adesão ao programa, foi superior aos investimentos destinados em bolsas de estudos e contribuiu financeiramente para a estabilização, manutenção e o potencial crescimento institucional nos últimos anos. Como apontam alguns autores, pôde-se apreender, com a pesquisa, que a redução fiscal foi o principal resultado positivo da adesão da IES ao programa.
Journal Leadership and Editorial Board
Authors: Bass Jordan
Published: November 2017

Journal Leadership and Editorial Board for Volume Three, Issue Three: Special Issue on Family Issues in Amateur Athletics
Cum se traduce ‘rușinea’. Abordare traductologică (II)
Authors: Jeanrenaud Magda
Published: November 2017

Pornind de la sfera semantică și lexicală a conceptelor honte (limba franceză) și, respectiv, rușine (limba română), îmi propun să examinez modul cum se traduce acesta în limba română pornind de la un studiu de caz. În acest scop, voi încerca să elaborez un studiu traductologic comparativ al lucrării lui Boris Cyrulnik, intitulată Mourir de dire. La honte (Éditions Odile Jacob, Paris, 2010) și a traducerii sale în limba română, intitulată Mai bine mor decît să spun. Rușinea (traducere din limba franceză de Valentin Protopopescu, Editura Trei, col. „Psihologia pentru toți”, București, 2012). Textul lui Cyrulnik are o particularitate: oscilează între factura literară și cea a unui text specializat. Din acest punct de vedere, transpunerea lui pune la încercare teoriile funcționaliste ale traducerii și, mai ales, teoria skopos-ului elaborată de Katharina Reiss și Hans Vermeer: este interesant de analizat cum „decodează” traducătorul „intenționalitatea” acestui tip de text, totuși specializat, cum decide el să transpună sfera sa semantică și lexicală în limba română.
Prima hartă a zăcămintelor de sare din România (1780). Toponimele corespondente actuale
Authors: Moscal Dinu
Published: November 2017

Istoricul exploatării sării în zona arcului carpatic reprezintă încă un deziderat pentru anumite perioade ale provinciilor istorice ale României, deși s-au scris relativ multe lucrări pe această temă.

Harta de la 1780 a zăcămintelor de sare din arcul carpatic reprezintă una dintre realizările importante în acest domeniu. Unul dintre lucrurile necesare acestui istoric este identificarea locurilor de unde se extrage sau s-a extras sare. După un scurt istoric al atestărilor primare legate de exploatarea sării pe teritoriul României, lucrarea de față prezintă contribuția lui Fichtel (1780) în identificarea zăcămintelor de sare din acest spațiu. Actualizarea toponimelor din hartă nu prezintă dificultăți pentru provinciile istorice Moldova și Valahia, însă nu la fel este și în cazul toponimelor din Transilvania, nomenclatura din perioada dominației maghiare (pînă în 1918) fiind în mare parte schimbată începînd cu anul 1919. Pentru toate acestea s-au dat corespondentele din nomenclatura actuală. Lucrarea oferă o actualizare a localizării izvoarelor, fîntînilor și sedimentelor de sare identificate de Fichtel, prin identificarea toponimelor corespondente actuale pentru cele indicate în hartă.
Pneumopericardium in the Neonate
Authors: Walker Tiffany L. , Shannon Dorothy A.
Published: November 2017

Abstract

Pneumopericardium occurs when air accumulates in the pericardial sac surrounding the heart and is one of the rarest forms of air leaks in neonates. Because of various advances in neonatal care, including gentler modes of ventilation, surfactant replacement, and antenatal steroids, the incidence of pneumopericardium has decreased. Despite the decrease in incidence of pneumopericardium, most cases arise in premature infants with a history of respiratory distress and mechanical ventilation. Evidence has shown that the incidence is inversely related to birth weight and that pneumopericardium has high mortality and morbidity rates.
Personal Marketing Framework based on QR Code
Authors: Pal Sanjay Kumar , Jha Khushbu Kumari
Published: November 2017

This paper will focus on the technique to build a responsive personal marketing framework for professional job seekers using Quick Response Code (QR Code). In today’s demanding job market, every career-minded individual has to first promote their value and benefits to a prospective employer through tools like resume, portfolios etc. The cut-throat competition among job applicants to get a particular job has increased the thought of creating more formal, precise yet informative and interactive tools to attain the opportunity in the first place itself. A unique QR image will be generated each time consisting of URL, Contact information, details about research paper or projects, link to the LinkedIn profile, etc. which can be easily scanned using a QR Code reader with an embedded camera. Thus presenting the candidate to be more tech proficient in front of an employer and showcasing that extra information without being lengthy and informal. The objective of this paper will always aim for the study of the application of QR Code in personal marketing methods and to analyse its benefits. The paper also proposes a methodology for the development of a unique system which will help a job seeker to make a compelling digital presence.
Coal Tailings as a Pozzolanic Material in Cements: A Preliminary Study for Their Use in Sleepers and Slab Track Railway System. Part I. Materials Selection
Authors: Yagüe Santiago , Sánchez Isabel , Vigil De La Villa Raquel , García-Giménez Rosario , Zapardiel Antonio , Frías Rojas Moisés
Published: November 2017

One source of kaolinite-rich wastes is from mine tailings and the generation of enormous volumes of mine tailings waste is standard practice in this industry. These volumes of waste are, at present, dumped, provoking significant environmental impact and transforming the environment. The impact of storing coal waste requires the study of eco-innovative solutions for the assessment of waste types. The present investigation has the objective of expanding the knowledge on the behavior of new siliceous-aluminum minerals with pozzolanic activity, of added value in the manufacture of similar cements. Four samples were characterized to determine their chemical, morphological and mineralogical composition. The samples were subjected to different thermal activation conditions for the transformation of an inert waste into a material with cementitious properties. XRD analysis have confirmed the total transformation of kaolinite into metakaolinite. The results have shown that after the activation process, the coal refuse presented good pozzolanic activity, meaning that it may be used as a pozzolanic addition in industrial cements, thereby removing high levels of contaminated waste from the environment. In subsequent investigations, research work will continue with the replication of cements with this pozzolanic addition for use in the manufacture of sleepers and slab track railway system.
Hydrazone Derivatives Enhance Antileishmanial Activity of Thiochroman-4-ones
Authors: Vargas Esteban , Echeverri Fernando , Upegui Yulieth A. , Robledo Sara M. , Quiñones Wiston
Published: November 2017

Cutaneous Leishmaniasis (CL) is a neglected tropical disease, which causes severe skin lesions. Due to the lack of effective vaccines, treatment can be complex and prolonged, high toxicity, side effects and high cost, there is an urgent need to develop alternatives for the treatment for CL that may have different mechanisms of action. In our effort to search for new promising hits against Leishmania parasites we prepared 18 acyl hydrazone derivatives of thiochroman-4-ones. Compounds were evaluated for their in vitro antileishmanial activity against intracellular amastigotes form of Leishmania panamensis and cytotoxic activity against human monocytes (U-937 ATCC CRL-1593.2); our results show that derivatization with acyl hydrazones significantly enhance the antileishmanial activity, among the compounds tested semicarbazone (19) and thiosemicarbazone (20) derivatives of thioflavanone display the highest antileishmanial activities with EC50 values of 5.4 and 5.1 µM both with low cytotoxicities, 100.2 a 50.1 µM resulting in high selectivity index (SI).
Has 20 Years of Japanese Earthquake Research Enhanced Seismic Disaster Resilience in Kumamoto?
Authors: Hirata Naoshi ,   Earthquake Research Institute, the University of Tokyo 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan
Published: November 2017

It has been about 20 years since the Headquarters for Earthquake Research Promotion (HERP) was established following the Great Hanshin-Awaji Earthquake Disaster. Now the time has come to examine its contributions to disaster resilience. On April 14 and 17, 2016, a series of large earthquakes, including M6.5 and M7.3 events, occurred in Kumamoto Prefecture in Kyushu, Japan. More than 200 fatalities and 8,600 totally collapsed houses were reported. The earthquakes occurred on known active faults, which were assessed by the Earthquake Research Committee (ERC) before the events. The regional disaster management plan by Kumamoto Prefecture had predicted the events reported by the ERC and estimated damages at about the same level as what was actually seen. However, even though the estimate was accurate, the countermeasures were insufficient: the local people still did not seriously expect a large earthquake to strike in their local area, and their efforts to enhance the disaster resilience of the Kumamoto area were insufficient. This suggests that the efforts by the HERP were not sufficient to make the local community resilient enough to withstand a large earthquake.
The Importance of Seismic Death Risk Assessment of Households in the Kumamoto Earthquake of 2016
Authors: Nakashima Tadayoshi ,   Hokkaido University Kita 13 Nishi 8, Kita-ku, Sapporo, Hokkaido 060-8628, Japan, Okada Shigeyuki , Shinoda Akane
Published: November 2017

This paper discusses the reduction effect of a foreshock on casualties during the mainshock of people who evacuated to shelters and their private cars during the 2016 Kumamoto earthquake. In the first part of this paper, we discuss the number of human casualties caused by the collapse of wooden buildings. The characteristics of casualties in the Kumamoto earthquake are classified as household attributes and building damage caused by the foreshock and mainshock. In the second part, we apply equations (Nakashima and Okada 2008 and Okada and Nakashima 2015) to the Masiki area to determine the total number of casualties with a focus on deaths. The number of deaths due to total building damage from the foreshock and the mainshock in the case of 0 evacuees was estimated as 147. We then estimated the reduction effect on the number of casualties caused by the foreshock by using the survey data of the mainshock and foreshock. We found that evacuation during the mainshock decreased the death toll by 128 people. Moreover, the number of injured people decreased by 657. Generally, most people who evacuate tend to return home over time. As a result, many people die at the time of a subsequent mainshock. It is important to provide death risk information to each household to support their decision-making regarding appropriate evacuation.
FINITE ELEMENT ANALYSIS USING SHELL ELEMENTS ON RETICULATED STRUCTURES
Authors: Selhorst Alexandre Huberto Balbino , Meyer Rafael Elias , Costa Tatielen Pereira , Isoldi Liércio André
Published: November 2017

This paper studies the possibility of using SHELL elements on structures that are usually designed using BEAM or BAR elements. Using SHELL elements in such structures, named reticulated structures, opens the possibility to remove material from the structures’ members by adding holes. Once the members get holes, the final weight of the structure and material consumption will drop. In order to develop the study, a total of three different structures were analyzed using the software ANSYS®. This software uses the Finite Element Method to solve the equations originated from the designed structure upon it is meshed and the boundary conditions are set. Several results between SHELL and SOLID elements for each one of the structures were compared. The comparison of SHELL model with a SOLID model is used as a verification process, for SOLID elements are known to return accurate values. All of the meshes were tested by the independence mesh study to check its convergence. It is shown that the results are in a very good acceptable range with differences no bigger than 0.1 mm for displacements, and the map of von Mises stresses are pretty similar. Von Mises stresses for Finite Element Analysis for the C-Shaped Truss are shown in a figure comparing the results between the two finite elements used. This figure shows that there are no major differences between the SHELL and SOLID analyses. The Finite Element Analyses results were compared to analytical solutions, also. In this case, a noticeable difference in one structure for von Mises Stress was found. This difference, however, is understandable and reasonable, given the works presented on this paper.
Changes in the two-dimensional and perimeter-based fractal dimensions of kaolinite flocs during flocculation: a simple experimental study
Authors: Zhu Zhongfan , Peng Dingzhi , Dou Jie
Published: November 2017

In this study, Couette flow experiments were performed to estimate the temporal evolution of the 2D and perimeter-based fractal dimension values of kaolinite flocs during flocculation. The fractal dimensions were calculated based on the projected surface area, perimeter length and length of the longest axis of the flocs as determined by sampling observation and an image-processing system. The 2D fractal dimension, which relates the longest axis length and projected surface area of flocs, was found to decrease with the flocculation time, corresponding to the production of some porous flocs from the flow shear. This fractal dimension finally reached a steady state, which resulted from a dynamic equilibrium among the floc growth, floc breakage and floc restructuring. The perimeter-based fractal dimension, which characterizes the relationship between the projected surface area and the perimeter of flocs, increases with flocculation time because the flow shear increases the collisions among the primary particles, and some irregular flocs are formed. The perimeter-based fractal dimension reaches a steady level because of the balance among floc aggregation, breakage and restructuring. In addition, a stronger turbulent flow shear makes the steady state of fractal dimensions occur early during flocculation.
CHANGES AND THREATS IN THE PRESERVATION OF THE TRADITIONAL MALAY LANDSCAPE
Authors: Harun Nor Zalina , Mohd Ariffin Noor Aziah , Abdullah Fadziah
Published: November 2017

The cultural landscape is regarded as being of the most complex designs which involves interactions between man, nature, cultural values and the associated built environment. Issues relating to the degradation of the cultural landscape are often caused by rapid urbanisation and industrialisation. The traditional Malay Landscape exists through harmoniously balanced interactions between man, nature and culture together with the traditional house, and contains unique and interesting features that have to be preserved as one of the most important cultural heritage sites. However, the preservation of heritage in Malaysia tends to focus more on architectural buildings rather than adopting a holistic approach that includes the surrounding environment of where the building is located. The absence of such approach has contributed towards the loss of the traditional Malay Landscape. This study highlights the changes and threats in the preservation of the traditional Malay Landscape by focusing on the preservation of a traditional house compound. The research employs a qualitative approach which involves site visits, interviews, and document analysis concerning the research topic. The old Malay villages located in Tumpat, Kelantan and Alor Gajah, Melaka have been selected as case studies. The findings reveal that the changes and threats include four underlying aspects; Unsuitable and inappropriate uses, Ownership Problems, Inadequate fund and consultation and Current development trends. The study concludes that the traditional Malay Landscape is facing numerous changes and threats in terms of its physical characteristics, environmental aspects and cultural values. In addition, the study reveals that traditional Malay landscape is not seen here as an integrating, holistic concept.
UNDERSTANDING LOCAL AUTHORITY PERFORMANCE THROUGH ROLE THEORY
Authors: Lim Sengboon , Abdul Malek Jalaluddin , Tahir Zurinah
Published: November 2017

Local government performance is frequently interpreted through stakeholders’ satisfaction measured by statistical analyses. Apart from testing the relationship, the perception of satisfaction on services provided is further influenced by the degree of expectation being met, and understanding the customer behaviour. Thus, this study attempts to explore an alternative explanation on the character of the local authority (LA) and put in perspective through the comprehension of the role theory. This was an exploratory case study on Kulim Hi-tech Local Authority, Malaysia. The mixed method approaches were firstly carried out by questionnaire surveys, followed by interviewing stakeholders and ended with site observations. Descriptive analyses were applied to the random samples. Findings showed that the LA has executed its roles of control and collect very well. However, it did not fare well in the role of publish.
Patients’ Experiences of Accessing Their Electronic Health Records: National Patient Survey in Sweden (Preprint)
Authors: Moll Jonas , Rexhepi Hanife , Cajander Åsa , Grünloh Christiane , Huvila Isto , Hägglund Maria , Myreteg Gunilla , Scandurra Isabella , Åhlfeldt Rose-Mharie
Published: November 2017

BACKGROUND

Internationally, there is a movement toward providing patients a Web-based access to their electronic health records (EHRs). In Sweden, Region Uppsala was the first to introduce patient-accessible EHRs (PAEHRs) in 2012. By the summer of 2016, 17 of 21 county councils had given citizens Web-based access to their medical information. Studies on the effect of PAEHRs on the work environment of health care professionals have been conducted, but up until now, few extensive studies have been conducted regarding patients’ experiences of using PAEHRs in Sweden or Europe, more generally.

OBJECTIVE

The objective of our study was to investigate patients’ experiences of accessing their EHRs through the Swedish national patient portal. In this study, we have focused on describing user characteristics, usage, and attitudes toward the system.

METHODS

A national patient survey was designed, based on previous interview and survey studies with patients and health care professionals. Data were collected during a 5-month period in 2016. The survey was made available through the PAEHR system, called Journalen, in Sweden. The total number of patients that logged in and could access the survey during the study period was 423,141. In addition to descriptive statistics reporting response frequencies on Likert scale questions, Mann-Whitney tests, Kruskal-Wallis tests, and chi-square tests were used to compare answers between different county councils as well as between respondents working in health care and all other respondents.

RESULTS

Overall, 2587 users completed the survey with a response rate of 0.61% (2587/423,141). Two participants were excluded from the analysis because they had only received care in a county council that did not yet show any information in Journalen. The results showed that 62.97% (1629/2587) of respondents were women and 39.81% (1030/2587) were working or had been working in health care. In addition, 72.08% (1794/2489) of respondents used Journalen about once a month, and the main reason for use was to gain an overview of one’s health status. Furthermore, respondents reported that lab results were the most important information for them to access; 68.41% (1737/2539) of respondents wanted access to new information within a day, and 96.58% (2454/2541) of users reported that they are positive toward Journalen.

CONCLUSIONS

In this study, respondents provided several important reasons for why they use Journalen and why it is important for them to be able to access information in this way—several related to patient empowerment, involvement, and security. Considering the overall positive attitude, PAEHRs seem to fill important needs for patients.
Pharmaceutical Fraud: Off-Label Marketing of Drugs in the United States, 2009-2016
Authors: Greenman Zac , CFE Dr. Cindy Greenman,
Published: November 2017

The Federal False Claims Act (FCA) is a law that enforces liability on companies (or persons) who defraud government programs. Its original purpose was to combat fraud against the United States Army during the Civil War. Under the original FCA private citizens could file a lawsuit on behalf of the government and receive a percentage of the recovery.

The False Claims Act has been somewhat effective in combating fraudulent claims by pharmaceutical manufacturers. According to the Department of Justice (DOJ) website over $19 billion has been collected from the pharmaceutical companies for various violations of the FCA including billing, marketing and pricing schemes.

Our research focused on all cases involving pharmaceutical manufacturers through False Claims Act (FCA) violations, specifically the Off-Label Marketing of Drugs. There were 22 cases in the eight years that our research covered. The total amount collected in the eight years was over $14.1 billion (Table). This was only those cases related to Off-Label Marketing. One company, Pfizer Corp., was involved in 4 of the 22 cases totaling $3,448 million over a five-year period. Johnson & Johnson Corp. settled 3 cases for a total of $2,299 million.
Development of hematopoietic stem cell transplantation at the Clinic of hematology, Clinical Center of Vojvodina in Novi Sad
Authors: Pejin Dusan
Published: November 2017

Hematology underwent substantial development in the second half of the 20th
century. Research into the possibility of treating affected experimental
animals with bone marrow transplantation was initiated at that time.
Successful treatment of leukemia in animals by giving them chemo- and
radiation therapy and subsequent administering of the bone marrow of a
healthy animal showed to the clinicians the way to apply transplantation in
humane medicine. The first allogeneic bone marrow transplantation in a
patient suffering from acute leukemia was done in the United States by Prof.
E. D. Thomas in 1957 after radiation of the entire body and chemotherapy with
cytostatic agents. The patient?s destroyed bone marrow was successfully
recovered by a voluntary HLA identical donor. This first experience
encouraged numerous hematologists so they prepared themselves for a new era
of treating malignant and benign hematological diseases. The Clinic for
Hematology in Novi Sad gained its first experiences in 1977 when a patient
with severe aplastic anemia successfully received, for the first time in our
country, the bone marrow transplant from his twin brother. After extensive
preparations at the Clinic for Hematology, in 1990, bone marrow and
hematopoietic stem cell transplantation from blood became a standard method
of treating malignant and benign hematological diseases. By 1999, the
transplant team successfully performed 20 transplantations, 4 in patients
with severe aplastic anemia, and 16 in patients with malignant hematological
diseases which were unresponsive to standard therapy such as leukemia,
myelodysplastic syndrome, multiple myeloma. Donors were HLA identical
relatives, twins in two patients. The best results were achieved in all
patients with aplastic anemia and in four patients with malignant
hematological diseases, while in others the transplantation had a monthslong
transient effect. Our experiences, as well as experiences across the world
and Europe, were invaluable. New recommendations were given, narrowing down
indications for allogeneic transplantation and the treatment has been focused
on autologous transplantation and new anti-tumor drugs.
Autologous stem cell transplantation for the treatment of hematological malignancies in the Clinical Center of Vojvodina
Authors: Urosevic Ivana , Savic Ivanka , El Farra , Sekulic Borivoj , Savic Aleksandar , Balint Bela
Published: November 2017

Introduction. Autologous stem cell transplantation combined with high dose
chemotherapy is an effective and safe approach in the treatment of different
hematological malignancies. Nowadays, autologous stem cell transplantation
represents a standard therapeutic option in the treatment of multiple
myeloma, lymphomas and other hematological malignancies. Aim is to analyze
the available medical data of patients with multiple myeloma, Hodgkin?s
lymphoma, non-Hodgkin?s lymphoma acute myeloid and lymphoblastic leukemia,
who underwent autologous stem cell transplantation, and to compare the
results with published data from other similar studies. Material and Methods.
A retrospective study included 90 patients with multiple myeloma, acute
myeloid and lymphoblastic leukemia, non-Hodgkin?s and Hodgkin?s lymphoma who
underwent autologous stem cell transplantation in the period from 2004 to
August 2017. Results. In relation to the underlying disease, the distribution
of the respondents was as follows: 39 patients had multiple myeloma, 25
non-Hodgkin?s lymphoma, 20 Hodgkin?s lymphoma and 6 had acute leukemia. 75
patients (89.3%) had the large volume apheresis procedure, while 9 patients
(10.7%) had the conventional two-day apheresis procedure. The average number
of the mononuclear cells in the apheresis product was 7,8x108/kg, and the
number of the CD34 + cells was about 12,11x106 kg. After applying the
conditioning regimen, depending on the underlying disease, neutrophils
engraftment mainly occurred on the 11th while the platelet engraftment
occurred on the 14th post-transplant day. Transplant-related mortality was
low, and the mortality rate was 3.57%. Conclusion. Autologous stem cell
transplantation is an efficient method of treatment for patients with
he?matological malignancies. It is associated with a low rate of
complications as well as low rate of transplant-related mortality.
Optimization of timing for hematopoietic stem cell transplantations in patients with myeloid leukemia
Authors: Popovic Stevan
Published: November 2017

Hematopoietic stem cells transplantations, allogeneic and autologous are
forms of treating acute myeloid leukemia, chronic myeloid leukemia and other
forms of malignant hematological diseases. Autologous stem cells
transplantations is the most intense form of chemotherapy with myeloablative
doses of cytostatic agents and with the aim of destroying ?each and every?
leukemic cell in the patient?s body. In order for patients to survive
myeloablation, infusion of their own stem cells which renew their own
hematopoiesis is carried out. Thanks to myeloablative and submyeloablative
conditioning regimen and the biological graft-versus-leukemia effect,
allogeneic has the best antileukemic effect and is considered the only form
of therapy which can lead to curing patients with malignant hemopathies.
However, the same or similar mechanisms, which are basically
graft-versus-leukemia effect, are responsible for the similar reaction of the
graft versus host and cause serious deadly illnesses, which is why
allohematopoietic stem cells transplantations is a risky form of treatment in
terms of ethics. Lower mortality of patients makes auto-SCT safer
ethical-wise, but its anti-leukemic effect is weaker.
Strumenti innovativi per la riqualificazione dei quartieri residenziali in Italia: tre casi esemplari
Authors: Morandi Corinna , Pessina Gloria , Scavuzzo Lina
Published: November 2017

Dagli anni ‘90 la realizzazione dei quartieri residenziali pubblici, avvenuta tra gli anni '50 e '70, ha ceduto il passo in buona parte delle città italiane ad interventi di riqualificazione, non solo fisica ma anche sociale, dei grandi complessi realizzati nei decenni precedenti, spesso percorsi da processi di degrado che ne hanno stigmatizzato negativamente l’immagine. I tre casi presentati nell’articolo descrivono diverse ed esemplari modalità di intervento pubblico o in partnership pubblico-privato, per la riqualificazione integrata di quartieri periferici: mentre due di essi (PRU via Artom e CdQ Sant'Eusebio) utilizzano in modo nuovo alcuni strumenti attuativi innovativi nelle modalità di finanziamento pubblico e nell’iter procedurale introdotti negli anni '90 –i cosiddetti “programmi complessi”-, il terzo caso (Villaggio Barona) propone, attraverso un intervento di dimensioni quantitativamente limitate e di iniziativa sostanzialmente privata, la riqualificazione di un ampio settore urbano in crisi di cui il “quartiere” diviene il nuovo centro spaziale e sociale. Dei casi si ricostruisce, oltre la contestualizzazione negli ambiti urbani di riferimento, l’insieme delle azioni di accompagnamento o di partecipazione che hanno teso a superare le situazioni di conflittualità che spesso compromettono l’efficacia di questi programmi.
El paisaje Urbano Histórico: modas, paradigmas y olvidos
Authors: Lalana Soto José Luis
Published: November 2017

Desde el Memorando de Viena, y tras seis años de debates y reuniones de expertos, está previsto que la 36ª Conferencia General de UNESCO adopte, en otoño de 2011, una Recomendación que propone una nueva aproximación a la conservación de los conjuntos urbanos históricos, cuyo elemento central es el concepto de paisaje urbano histórico. El paisaje urbano histórico supone la adaptación de la conservación del patrimonio urbano a los requerimientos de la sostenibilidad, y un avance hacia la consideración integrada de los diversos tipos de patrimonio y sus relaciones, pero plantea al mismo tiempo graves problemas de interpretación y de aplicación. El término paisaje está de moda y permite integrar muchos aspectos diversos en una sola palabra, tantos que es impreciso, difícil de aplicar y fácil de tergiversar. Por otra parte, este concepto se propone como una respuesta a los ‘nuevos’ problemas que afronta la conservación de los conjuntos históricos, pero en su formulación está ausente la reflexión crítica acerca de la cuestión social (cómo revitalizar sin gentrificar los conjuntos urbanos históricos) que, planteada desde hace décadas, sigue lejos de estar resuelta.