bluuebunny/crossref_metadata_2025 huggingface dataset:
Riqueza avifaunística e distância do centro nas floradas de Handroanthus impetiginosus, malha urbana de Iporá, Goiás
Authors: Souza Vitoria Cristine de Oliveira Silva , Coelho Moara Lemes , Blamires Daniel
Published: February 2025

Árvores proporcionam alimentos, e também criam, modificam ou mantém um habitat físico para si mesmas e outras espécies. Contudo, poucos trabalhos sobre plantas e aves em áreas urbanas foram elaborados no Brasil. Assim, este estudo avaliou o efeito da distância do centro na riqueza avifaunística, em floradas de Ipê-Roxo Handroanthus impetiginosus (Mart ex DC.) Mattos, malha urbana de Iporá, estado de Goiás. As ruas foram percorridas entre maio a setembro 2022 e junho-julho 2023, à procura de florações, sendo o monitoramento avifaunístico entre 6h30 e 9h30 da manhã. A copa de cada árvore, com fenologia floral entre 25-100%, foi inspecionada durante 30min. Um total de 72 árvores foram monitoradas (36h-atividade). Houve uma relação negativa e significativa entre as variáveis riqueza avifaunística e distância do centro (r= -0,244; p<0,05), devido provavelmente a uma arborização mais antiga na região central da malha urbana. A maior proximidade de H. impetiginosus a outras árvores no centro, provavelmente resultou em ambientes mais heterogêneos e complexos estruturalmente, favorecendo uma maior riqueza de aves. Mais estudos futuros, tanto em Iporá quanto nas demais cidades do estado de Goiás, poderão esclarecer novos aspectos sobre riqueza avifaunística em florações.
Desafios no diagnóstico de linfoma intestinal em cadela: relato de caso
Authors: Assis Andrelle Martins , Ferreira Jordanna Afonso Mendes , Ferraz Henrique Trevizoli , Romani Alana Flávia , Silva Luciano Schneider da , Ávila Ana Beatriz Gonzaga de , Quintino Kálita Dias , Tomasini Isadora Correia Gomes
Published: February 2025

O linfoma intestinal é uma neoplasia linfoide localizada em região de trato gastrointestinal e/ou linfonodos mesentéricos que acomete, na maioria das vezes, animais idosos ou adultos, sendo a maior casuística em cães de grande porte. Os sinais clínicos são inespecíficos e, por vezes, confundem-se com diagnósticos diferenciais de doenças não neoplásicas. Sabe-se que cães não tratados apresentam sobrevida média de quatro a seis semanas após o início dos sinais clínicos ou diagnóstico e, por isso, o prognóstico é reservado. O objetivo com este trabalho foi relatar e discutir o caso de uma cadela de dois anos de idade, da raça Shih tzu, atendida em um Hospital Veterinário na cidade de Goiânia-GO, com linfoma em cólon descendente, e o percurso desafiador no diagnóstico deste. A paciente apresentava histórico de hematoquezia crônica, fezes amolecidas e perda de peso. No período que antecedeu o diagnóstico da neoplasia, a paciente foi identificada com giardíase, toxocaríase, hipersensibilidade alimentar e erliquiose. Foi possível chegar ao diagnóstico tumoral com auxílio de exames laboratoriais e, principalmente, de imagem como ultrassonografia abdominal, radiografia contrastada, colonoscopia e tomografia computadorizada, para além do diagnóstico definitivo com exame histopatológico de amostras da região acometida.
Genomic characterization of porcine RVH detected in Brazil
Authors: Costa Fábio Burack , Flores Patrícia Soares , Mendes Gabriella da Silva , Santos Norma
Published: February 2025

Background: Rotavirus aspergastroenteritidis (also called Rotavirus H; RVH) has been detected in humans, pigs, and bats, and is considered an emerging pathogen; consequently, information regarding its genome, epidemiology and evolution is needed. Methods: RVH strains described in this study were detected in stool samples from post-weaning asymptomatic piglets in the state of Rio de Janeiro, Brazil. RVH genomic segments were amplified by RT-PCR using specific primers and the amplicons were sequenced. Results: Phylogenetic analysis classified both (BP92 and BP260) strains as I3 genotype. The BP92 strain was further identified as genotypes G4-I3-A6-N1-E4-H3. However, some gene sequences showed either percentages of identity below the suggested cut-off value for the identified genotype or showed similarity above the cut-off values established for different genotypes. Conclusion: The Brazilian BP92 strain may have a genomic constellation distinct from those of previously described porcine RVH strains.
Análise de parasitos com potencial zoonótico em fezes de cães domiciliados em comunidade de Manacapuru-AM e promoção de educação em saúde
Authors: Rebello Jordana Elias , Neves Kilma Cristiane Silva , Espírito Santo Edson Francisco do
Published: February 2025

Os cães são considerados um dos principais reservatórios de helmintos e protozoários, e em função disso, é fundamental o conhecimento da prevalência destes parasitos, uma vez que são zoonóticos e há um intenso convívio entre seres humanos e animais. Esta pesquisa objetivou determinar a prevalência de enteroparasitos presentes em fezes de cães domiciliados na comunidade “Sê tu uma benção” localizada no município de Manacapuru-AM, e promover Educação em Saúde sobre parasitoses zoonóticas. Os materiais biológicos foram coletados entre agosto de 2023 e janeiro de 2024, sendo analisados utilizando-se a técnica de Willis-Molay. Os dados referentes aos animais, manejo e ambiente foram coletados via aplicação de questionário aos tutores, e para as ações de educação em saúde foram utilizados fôlderes explicativos. Os resultados foram correlacionados com as variantes raça, idade e peso dos animais parasitados. No total, 30 amostras fecais foram analisadas, sendo 18 resultados positivos, com prevalência em cães sem raça definida (83,33%), com idade > 1 ano (77,77%), pesando em média 13 kg, e não houve predileção sexual. Com relação aos tutores, 76,47% afirmaram ter conhecimento sobre as zoonoses parasitárias. De acordo com os resultados, constatou-se uma grande prevalência de parasitoses zoonóticas na comunidade, mesmo com a conscientização da população. Espera-se que essa pesquisa contribua para os dados epidemiológicos de endoparasitos em cães no estado do Amazonas, uma vez que tais pesquisas ainda se encontram escassas, bem como no aperfeiçoamento das medidas profiláticas visando minimizar a disseminação de parasitos entre cães domiciliados e tutores.
Impacto ambiental y toxicológico por plomo en granos de soja (Glycine max L.) comercializados en el cantón Quinsaloma, Ecuador
Authors: Monrroy Roberto Johan Barragan , Mendoza Juliana Eugenia Soto , Cedeño Carla Maria Sabando , Sabando Juan Alberto López , Mendoza Ana Madelaine Macías , Ponce Mariela Alexi Diaz , Monrroy Doris Ivonne Vergara
Published: February 2025

La contaminación del suelo por metales tóxicos, representa una seria amenaza para la salud humana y el ambiente. Este estudio se justifica en evaluar los niveles de plomo en granos de soja (Glycine max L.) en el cantón Quinsaloma, Ecuador, debido a su relevancia para la seguridad alimentaria y su alineación con los Objetivos de Desarrollo Sostenible, particularmente en salud y bienestar. El objetivo principal fue determinar las concentraciones de plomo en los granos de soja y evaluar los riesgos associados, además, se utilizó una metodología basada en la espectrometría de absorción atómica y análisis estadísticos como ANOVA y pruebas de Shapiro-Wilks para evaluar el impacto ambiental. Adicionalmente, los resultados mostraron que las concentraciones promedio de plomo en los granos de soja fueron de 1,28±0,12 mg/kg, se observó un impacto ambiental notable, con niveles de plomo que exceden los límites permitidos por normativas nacionales e internacionales como la NTE INEN 452:2013, Codex Alimentarius y Unión Europea. Las concentraciones específicas de plomo variaron entre 0,90 mg/kg y 1,42 mg/kg en diferentes muestras comerciales y alcanzaron hasta 1,47 mg/kg en la muestra testigo, estos análisis toxicológicos revelaron que el consumo de los granos podría representar un riesgo considerable para la salud, especialmente en niños y mujeres embarazadas. Se concluye que la investigación demostró altos niveles de plomo detectados en los granos de soja y su impacto adverso indican la necesidad urgente de implementar estrategias de mitigación y vigilancia ambiental en el cantón Quinsaloma.
Evidence for visual evasion of arctiid moth predators: the influence of conspicuous coloration patterns on predation in Utetheisa ornatrix caterpillar models
Authors: Leão-Pires Thiago A. , Pereja Martins F.
Published: February 2025

In nature, organisms have developed various defense mechanisms against predation. Aposematism, in which animals display conspicuous coloration combined with a defense mechanism to deter predation, is one of the primary defensive strategies studied. Conspicuous color patterns have been the focus of intense and justified attention by biologists since the time of Charles Darwin. Many unpalatable species, especially among insects, exhibit conspicuous coloration. However, by evolving conspicuous coloration similar to that of an unpalatable species, palatable animals can also gain an evasive advantage through mimicry, without the need to develop a real defense. In Utetheisa ornatrix, coloration manifests in different patterns, including black, yellow, and white, and is considered conspicuous and aposematic for some species. This study evaluated the influence of conspicuous coloration on predation in U. ornatrix larval models, testing two hypotheses: first, that models with conspicuous coloration are less predated than cryptic or non-conspicuous models; second, that models with a fully developed conspicuous pattern are less predated than those with intermediate patterns or purely black coloration. The results indicate that among the tested conspicuous coloration models, predators avoided the pattern most similar to U. ornatrix and the cryptic pattern, showing a preference for the non-conspicuous pattern. Additionally, among the conspicuous patterns, the black-and-white and fully developed patterns were less predated than the black-yellow and purely black patterns, with the latter being the most predated.
Implementation of Smart Contracts in TikTok Influencer Marketing
Authors: Sudadi Pranata  , Fajrinoor Fanani  , Dini Hidayati  , Rosa Lesmana  , Zinhle Ndlovu
Published: February 2025

The rapid growth of TikTok as a social media platform has transformed influencer marketing, offering brands unparalleled opportunities to engage with their target audiences. However, issues such as lack of transparency, trust, and inefficiencies in payment processes remain significant challenges in influencer marketing, highlighting a critical GAP in both literature and practice. This study addresses these challenges by exploring the implementation of smart contracts, powered by blockchain technology, as a novel solution. Smart contracts provide an automated, secure, and transparent framework for managing influencer marketing campaigns. The research employs a quantitative approach with Structural Equation Modeling (SEM) as the primary methode, utilizing the SmartPLS tool. Data were collected from 200 respondents who are active TikTok users and have engaged with influencer marketing campaigns. The findings reveal that credibility, informativeness, and entertainment positively affect advertising value, while irritation negatively impacts it. Furthermore, advertising value significantly influences advertising attitude, which, in turn, impacts purchase intention. Additionally, advertising attitude moderates the relationship between advertising value and purchase intention, strengthening its effect. These results and conclusions emphasize the transformative potential of smart contracts in enhancing transparency, trust, and efficiency within influencer marketing. By introducing blockchain-based solutions, this study makes a significant novelty contribution to the literature, offering practical insights for brands and marketers. Specifically, smart contracts enable brands to ensure fair compensation, accurate performance measurement, and improved campaign outcomes. This study underscores the importance of leveraging cutting edge technologies to address existing gaps in influencer marketing, ultimately paving the way for more effective and transaction.
A Comprehensive Framework for Enhancing Blockchain Security and Privacy
Authors: Faisal Yusuf  , Riya Widayanti  , Sausan Raihana Putri  , Aulia Wellington
Published: February 2025

Blockchain technology has gained widespread adoption across various industries due to its decentralized and transparent nature. However, its inherent characteristics, such as immutability and openness, expose the system to critical security threats and privacy concerns. This study aims to develop a comprehensive framework to enhance blockchain security and privacy, addressing prevalent challenges such as data breaches, transaction anonymity, and resistance to cyberattacks. The proposed framework integrates advanced cryptographic techniques, including Zero Knowledge Proofs (ZKP), Secure Multi Party Computation (SMPC), and enhanced encryption protocols, alongside innovative consensus mechanisms to improve system robustness. A simulation-based evaluation and a real-world case study were conducted to validate the framework. The results demonstrate significant improvements in mitigating security vulnerabilities, such as 51% attacks and double spending, while ensuring enhanced privacy through anonymized data handling and confidentiality-preserving transactions. Furthermore, the case study confirmed the framework's practicality and adaptability across diverse applications. These findings highlight the proposed framework's potential to establish a secure and privacy-preserving blockchain ecosystem, offering a solid foundation for future research and implementation in both public and private blockchain networks.
Optimizing Blockchain Digital Signature Security in Driving Innovation and Sustainable Infrastructure
Authors: Agung Rizky  , Nugroho Rayhan Wahyu , Wahyu Sejati  , Mumpuni  , Omar Sy
Published: February 2025

Indonesia experienced a significant spike in cyberattacks, averaging 158 attacks per second, indicating a high risk for digital systems, especially in the government and business sectors. The large number of attacks has caused financial losses and damaged public trust, indicating that data protection is not optimal. Traditional authentication systems based on centralized servers increase the risk of document leaks and forgery. To address this, this study proposes a Blockchain-based digital signature solution called AlphaSign. This technology strengthens data resilience and document verification reliability with an Agile Scrum approach, enabling iterations that are responsive to user needs. Alpha Sign aims to create a secure Blockchain-based digital signature system, prevent document forgery, and accelerate verification through QR code automation. This system supports the development of sustainable digital infrastructure, in line with the SDGs, especially Goal 9 (Infrastructure Innovation) and Goal 16 (Resilient Institutions). With Blockchain technology, Alpha Sign records each signature in a decentralized manner, reduces the risk of hacking, and enables real-time document verification through QR codes, providing security and transparency for large agencies and the public sector.
Voltage sagging mitigation with liquid starter for motor starter in PT Solusi Bangun Indonesia TQ 1 system
Authors: Wijanarko Rahmat Febrianto
Published: February 2025

Voltage stability is one of the main concerns in the electric power system. One of them is related to the voltage sagging problem. The cause of voltage stability problems in the electric power system is the motor starting event. The current motor starting method that is often used is to use a VFD soft starter. There is another method to mitigate voltage sagging problems during motor starting events using the liquid starter technique which is still rarely used. The simulation results obtained show that by using a liquid starter there is a slight decrease in the voltage profile, low starting current, smooth start, little impact on the grid. This was proven in the application of a liquid starter using etap software and Matlab plotting. The smallest value of the voltage profile was 90.35% and the starting current was 6 times lower than the direct online method. From this application, the liquid starter method has proven to be much more effective in overcoming high voltage and current sags during motor starting events.
Analysis of Leakage Current Calculation Through Thermal Failure Voltage on 150/20 kV Transformers in GIS Simpang, Surabaya
Authors: Widagdo Reza Sarwo , Andriawan Aris Heri , Suri Tauladan Imam , Ivan Maulana Ade
Published: February 2025

In the current test, leaks really need to be carried out at GIS Simpang. This test was carried out by strengthening the 20 kV incoming cable in the GIS Simpang 150/20 kV transformer bay. The impact of measuring this leakage current is to reduce the occurrence of leakage currents so that they are not too severe because this can determine how much the leakage current increases in the incoming cable. The trend test results were measured to determine the comparison between the leakage current in January and the leakage current measurement process at GIS Simpang. Based on the results of leakage current testing on transformer 1 and transformer 2 incoming 20 kV cables from several phases, it shows that the results of the leakage current trend in the cables have not increased significantly. However, from the calculation results listed, it can be seen from the comparison table that the results have increased during the calculation and have slight differences compared to the leakage current measurement results themselves. This is because from the calculation results, the cable temperature detection experienced a slight increase in the cable temperature as measured by thermovision to determine the thermal failure voltage. However, the cable is still suitable for operation because the temperature of the cable itself has a standard that does not exceed 150C for several measured cable phases.
In Process and Quality Control Tests for Tablets: A Review
Authors: Nikam Nilam A. , R.Shinde (Kadam) Sandhya , kumar K. Redasani Dr. Vivek
Published: February 2025

All pharmaceutical enterprises aim to create highquality products, which is accomplished by
permitting quality control methods for both inprocess and finished products. Assuring that the
intermediates, packaging materials, and final
pharmaceutical tablets adhere to approved
specifications or standards for efficacy, safety, and
elegance that reassure the consumer that the
products perform consistently and in a manner
satisfactory for the purpose for which they are
recommended is known as in-process quality
control. This concept encompasses all steps that are
carried out before, after, and during production,
including the establishment of specifications,
sampling, pertinent testing, and analytical
clearance. Quality control emphasizes product
testing for flaws, which makes it easier for the
manufacturer to deny product releases or conduct
any necessary research to improve pharmaceutical
tablets before releasing into the market. Since
several pharmacopoeias have established varying
stated limitations, the value must fall within these
limits to be considered compliant with the
standards. In order to verify the quality of
pharmaceutical dosage forms, pharmacopoeias are
compared in an attempt to communicate the
harmonized limitations, which ensure that the
goods fulfill the specifications. This study aims to
analyze different pharmaceutical tablet quality
control evaluations based on distinct
pharmacopoeia standards.
The Knowledge and Awareness of General Dental Practitioners and Medical Specialist Regarding the Management of Snoring and Sleep Apnea Using Oral Appliances in Tamilnadu Population- A Questionnaire Study
Authors: Mersonm Mersonm , Sagadevan MDS DrSenbagavalli , Abraham MDS Dr.Sonia , Dr Prabhu K MDS Dr Prabhu K MDS
Published: February 2025

Background: Obstructive Sleep Apnea (OSA) is a
prevalent but underdiagnosed condition that can
lead to severe health complications if left untreated.
Oral appliances (OAs) have emerged as an
alternative to Continuous Positive Airway Pressure
(CPAP) therapy, particularly for mild to moderate
OSA. However, awareness and knowledge about
OA therapy among healthcare professionals,
especially dentists and general practitioners, remain
limited.
Objective: This study aims to assess the awareness
and knowledge of sleep apnea management among
dentists and general practitioners in Tamil Nadu,
focusing on the role of oral appliance therapy in
OSA treatment.
Methods: A descriptive cross-sectional study was
conducted among healthcare professionals,
including general dentists, general medical
practitioners, pulmonologists, and ENT specialists
in Tamil Nadu. Data were collected through an
online questionnaire (Google Forms), comprising
multiple-choice, Likert-scale, and Yes/No
questions. A total of 305 responses were analyzed
using SPSS software.
Results: Among the respondents, 65.4% were
general dentists, 31.4% were general medical
practitioners, and the remaining were specialists.
Only 28.3% demonstrated complete awareness of
oral appliances, while 51.9% had partial knowledge
but expressed interest in learning more. A majority
(72.5%) identified common side effects of oral
appliances, such as jaw pain and tooth movement.
Additionally, 72.1% correctly identified
polysomnography as the diagnostic test for OSA
before prescribing oral appliances. A significant
association was found between profession and
knowledge about oral appliance suitability and
management responsibility (p=0.037). Despite this,
only 10% had attended training or workshops on
OSA management with oral appliances.
Conclusion: The study highlights a substantial
knowledge gap regarding OSA management and
oral appliance therapy among healthcare
professionals in Tamil Nadu. Although many
practitioners recognize the role of oral appliances,
formal training remains inadequate. Strengthening
education and interdisciplinary collaboration
between dentists and general medical practitioners
is essential for improving OSA diagnosis and
treatment outcomes.
Role of oral food intake amount in intestinal absorption of morphine in rats
Authors: Sugino Masahiro , Nakadate Shou , Watanabe Tetsuya
Published: February 2025

Defects in oral intake cause morphological
changes,such as atrophy in the intestine; however, the
resulting changes in pharmacokineticsof administered
drugs have not been elucidated. The present study
focused on the effect of fasting and feed restriction on
morphine pharmacokinetics.Morphine was orally
administered to fasted and feed restriction rat
groups.Plasma morphine concentration and the area
under the curve (AUC) were measured and compared
among groups.The AUC in fasted and feed restriction
groups markedly increased compared with that
reported for the control group.This increment was
dependent on the feed restriction ratio, and not on the
fasting period.The findings of this study will help
predict the safety of morphine after oral
administration.
Formulation and Evaluation of Herbal Facewash Tablet
Authors: Ramya Patnala , Diya Abhaya , Reslin Aysha , Siraj I.V Muhammed , Shahala K P Shahala K P , Nihla Fathima Nihla Fathima , Uthara Raj Uthara Raj
Published: February 2025

The formulation of a herbal
facewash tablet incorporating liquorice
(Glycyrrhizaglabra) and neem (Azadirachta indica)
aims to provide a natural, effective, and convenient
skin care solution. Both liquorice and neem are
renowned for their therapeutic properties, with
antinflammatory and antioxidant benefits, while
neem is known for its antimicrobial, antiinflammatory, and purifying effects. In this study,
herbal extracts of liquorice and neem we combined
to create a tablet-based facewash, which promises
gentle yet effective cleansing, while nourishing and
protecting the skin. The tablets were developed
using herbal extracts, binders and excipients,
ensuring ease of use and minimal environmental
impact. Key quality parameters, including tablet
hardness, pH,and cleansing efficiency, were
evaluated. The product’s dermatological safety and
effectiveness in cleansing and removing impurities
were also tested. The results suggest that the
liquorice and neem-based herbal facewash tablet is
a promising, eco-friendly alternative to liquid
facewash products, offering a natural approach to
skincare with potential benefits for acne-prone and
sensitive skin types.
Formulation and Development of Herbal In-Situ Sustained Release Gel for Otitis Media
Authors: Dev Soni Dev Soni , Dr. Mehul Patel Dr. Mehul Patel , Dholakia Dr. Mansi , Shah Bhakti
Published: February 2025

The purpose of this study was to highlight the
potential of methanolic extract of Eclipta Alba to
develop in-situ sustained release otic gel for the
treatment of Otitis media. Otitis Media is a medical
condition that affects middle ear majorly in young
children. Primarily it is categorized into Acute
Otitis Media and Chronic Otitis Media. Eclipta
Alba. commonly known as Bringraj has been used
traditionally for hair related purposes. However it
has proven antimicrobial activity against Otitis
media causing bacteria. In following experiment, a
herbal in-situ thermosensitive gel was prepared by
utilizing poloxamer 407 and poloxamer 188. The
optimized batch C2 which had 20%W/V poloxmer
407 and 15% w/v poloxamer 188 were found to be
having the satisfactory release profile of almost
70% in 5.5 hours. Other evaluation parameters like
viscosity, gel strength and pH were found
satisfactory in formulation
“Merkel Cell Carcinoma: Pathogenesis, Clinical Features, Mechanotransduction, and Emerging Therapeutic Perspectives”
Authors: Komal Ms.Dapase , Kedar Ms.Asmita , Chikhale Ms Snehal , Kotkar Ms. Priya , Khemnar Ms . Pradnya , More Mr.Vaibhav
Published: February 2025

Merkel cell carcinoma (MCC) is a rare and
aggressive neuroendocrine skin cancer with a high
propensity for local recurrence and distant
metastases. It arises from mechanoreceptor Merkel
cells in the skin. MCC typically presents as a
painless, rapidly growing, erythematous to
violaceous nodule on sun-exposed areas of older
adults or immunosuppressed individuals.
The pathogenesis involves a complex interplay
between ultraviolet (UV) radiation exposure and
the Merkel cell polyomavirus (MCPyV), which is
detected in a significant proportion of cases. The
prognosis of MCC is influenced by tumor size,
lymph node involvement, and the presence of
metastases.
Management strategies for MCC require a
multidisciplinary approach, including surgical
excision, sentinel lymph node biopsy, radiation
therapy, and systemic immunotherapy with
immune checkpoint inhibitors targeting the PD1/PD-L1 pathway. The lesion is found in sunexposed areas and presents as a small, violet, raised
nodule. Immunohistochemical features are
typically sufficient for diagnosis.
MCC is most common in the white population, and
risk factors include advanced age, UV exposure,
male sex, immunosuppression (such as AIDS/HIV
infection, hematological malignancies, or solid
organ transplantation), and Merkel cell
polyomavirus infection.
Merkel cell carcinoma originates from Merkel cells
in the epidermis, which are specialized epithelial
cells involved in sensory perception. Symptoms
often include a rapidly growing, painless nodule or
ulcer on sun-exposed areas, particularly the head
and neck.
Development and Evaluation of Dosage Form for Dental Drug Delivery System
Authors: Bhandari Mayuri , Chaudhari Yogesh
Published: February 2025

Controlled drug delivery system has
more important in dental drug delivery system so as
to overcome the problems related to certain
periodontal diseases condition like Gingivitis and
Periodontitis. This research paper will overcome
the problems related to the pain and loosening of
the teeth by loading the transferosomes into the
film by using the drug levofloxacin hemihydrate.
Instead conventional dosage forms like tablet and
capsules the transferosomes loaded drug film will
be more patient compliance and will be sustained
release of the drug by not getting the drug waste.
Formulation and Evaluation of Mimosa Pudica Incorporated Toothpaste
Authors: Alfiya T A Alfiya T A , Ameera M Ameera M , Beema Abbas Beema Abbas , Devika M S Devika M S , Asweel K Moosa Asweel K Moosa , Jilby Saju Jilby Saju
Published: February 2025

Mimosa pudica known for its
medical qualities, it has potential for use in
toothpaste and other dental care products.
Alkaloids, flavonoids, and tannins represent a few
of its bioactive substances that have antibacterial,
anti-inflammatory, and antioxidant properties that
may help to improve dental health. According to
studies, it may lessen plaque, dangerous germs, and
gum inflammation, hence preventing gum disease
and cavities. This study looks at the advantages of
Mimosa pudica toothpaste, including its function in
boosting gum health and fresh breath, as well as its
safety and effectiveness when compared to
conventional alternatives. Although further
research is required to validate its broad usage, it
provides a natural substitute for traditional
toothpaste with fewer adverse effects.
Dhava (Anogeissus Latifolia Wall.) Botanical, Chemical And Pharmacological Review Of An Ayurvedic Medicinal Plant
Authors: ShubhangiD Dr.Chavan , Prachi Dr. Nandwate , Dr.More D.B Dr.More D.B , Mansi Dr. Londhe
Published: February 2025

Anogeissus latifolia wall has best
antidiabetic activitynowadays there is increase in
number of diabetic patients so this drug works
magicallyas it contains lots of
antimicrobial,antioxidant properties it has natural,
ecofriendly source, and no side effects & greater
bio availability . Availabilty of Anogeissus latifolia
through all over India, Myanmar, Nepal and Sri
Lanka, and found throughout tropicalAsia. A tree of
tropical and subtropical climates, it is found in
deciduous or semi-evergreen forests. It is a
common element in teak forests but also occurs in
the understorey of dipterocarp forests, in bamboo
forests. It is also present in vegetation under semiarid conditions such as savanna woodland and dry
rocky hills. It is usually associated with Albizia
lebbeck, Dalbergia spp., Grewia tiliaefolia, Albizia
amara, Gyrocarpus jacquini and Mesua ferrea.Cost
effectiveness of Dhava bark ash can be used to
filter heavy metals and fluoride from water,it can
be a low-cost,low maintenance,and
environmentally friendly technology. In Digestive
system it is Absorbent in nature indicated in
Dysentery, Diarrhea, bleeding piles etc.In
Circulatory System it is indicated in bleeding
disorders. In Excretory system it reduces urine
output. decoction of stem used in diabetic
condition.
Botanical Insights into Peptic Ulcer Disease: Therapeutic Potential of Medicinal Plants
Authors: Sharma Utkarsh
Published: February 2025

This article investigates the
relationship between medicinal plants and their
therapeutic effects, specifically targeting peptic
ulcers in the stomach. While traditional uses of
medicinal plant extracts often focus on skin
conditions, superficial ailments like ulcers can also
affect the gastrointestinal tract. To evaluate the
impact of specific medicinal plants on peptic ulcer
disease, we will extract their chemical compounds
using methods such as Soxhlet extraction, TLC,
and HPLC. A disease model will then be
established using laboratory animals, including
rats, mice, and guinea pigs, with ulcers induced
through various chemical and physical techniques.
After administering specific doses of the selected
medicinal plants, we will assess the animals'
responses to the induced ulcers and the treatments.
The research will highlight several plants,
including Urtica simensis, Cucumis melo,
Zanthoxylum armatum (tambulin), Abrus
precatorius and Jasminum sambac, ultimately
providing a comprehensive analysis of their
efficacy in treating induced ulcers in a laboratory
context.
The Comparison of Analgesic Effects of Ketorolac with Tramadol–Ketorolac Combinationin Patients with PostOrthopedic Surgical Painat Trauma Centerof Dr. M. Djamil Padang Central General Hospital
Authors: Ramadhani Putri , Rahma Fazira , Fauziah Fitra , Neldi Vina , Sofitriana Lisa , Kardela Widya , Agustina Endang
Published: February 2025

Post-operative pain is the most
common problem felt by patients. As many as 80%
of patients experience acute pain after a surgical
procedure. Pain management is critical and is a
matter of concern in post-surgical patients. This
study aims to compare the analgesic effect of
Ketorolac with the combination of TramadolKetorolac in patients with post-orthopedic surgical
pain at Trauma Center of Dr. M. Djamil Hospital
Padang (From January until March, 2023). This
study is retrospective with an analytical
observational study design using a cross-sectional
design and a time-limited sampling method. Pain
scale assessment was carried out using visual analog
scale (VAS) scores. The results showed that the
population of 97 patients, samples that met the
inclusion criteriawere 52 patients. The group of
Ketorolac was 18 patients, while the TramadolKetorolak combination group was 34 patients. The
analysis was conductedbyMann-Whitney Test. The
statistical results of the pain level and length of stay
(LOS) in the administration of the ketorolac with the
tramadol-ketorolac combination showed there was
no significant difference with sig. > 0.05. This study
concludes that there is no significant difference in
the analgesic effect of the Ketorolac with TramadolKetorolac Combination based on the pain scale and
LOS in patients with post-orthopedic surgical pain
at Trauma Center of Dr. M. Djamil Padang Hospital.
Historical significance, ingredients and clinical efficacy of parijatak cold cream
Authors: Prabhakar garud Prerana
Published: February 2025

The study aimed to create and assess a herbal
cosmetic cream for skin improvement and
hydration,taking inspiration from traditional Indian
medicine,the cream include night jasmine, nutmeg
and vit E for nourishing dry skin as well as red
sandalwood for anti aging benefits and scar
removal,Stability tests showed the cream is safe for
use as a skin barrier
Breaking the Monolith: Lessons from the Edge Computing Frontier
Authors: Kadali Ravi Sastry
Published: February 2025

This article examines the journey of
transforming a monolithic application into a
distributed edge computing architecture,
highlighting the challenges, solutions, and lessons
learned during the process. The article presents an
overview of the initial implementation challenges,
including the distributed monolith trap, and
describes the subsequent paradigm shift that led to
successful adoption of edge computing principles.
Through detailed examination of architectural
principles, implementation strategies, and security
considerations, the article demonstrates how
organizations can effectively transition from
traditional monolithic structures to resilient,
scalable edge computing systems. The article
emphasizes the importance of proper service
boundaries, data gravity considerations, and
location-aware microservices in achieving optimal
system performance and reliability.
Security in Storage Area Networks: A Technical Overview
Authors: Talluri Durvasulu Mohan Babu
Published: February 2025

Storage Area Network (SAN) security has emerged
as a critical component of modern enterprise
infrastructure, addressing the challenges posed by
exponential data growth and evolving cyber threats.
This technical article examines the fundamental
components and implementation strategies for
securing SAN environments, encompassing access
control management, data protection mechanisms,
network security infrastructure, physical security
controls, compliance frameworks, and best
practices. The comprehensive article covers
advanced technologies including artificial
intelligence-driven monitoring systems, quantumresistant encryption protocols, and automated
incident response capabilities, while highlighting
the importance of maintaining a balance between
security measures and operational efficiency.
Through the integration of multiple security layers
and automated controls, organizations can establish
robust defense mechanisms against emerging
threats while ensuring optimal performance of their
storage infrastructure.
Controversies in Paternity: An Insight into the Nigerian Culture
Authors: Idoghor Dr Uduak
Published: February 2025

The Blacks Law Dictionary defines a child as „a
progeny of parentage‟.
Nigeria is a patriarchal society and the pride of the
family is in being able to procreate and even more,
in having male children. Where a family is not able
to have children spews all kinds of scandals, insults
and uncanny speculations. Worse than not bringing
forth children is a paternity dispute. This is a
doctrinal research focused on unveiling issues
emanating from paternity disputes by way of giving
an insight into the Nigerian culture. The research
has explored the opinions and rulings of legal
authorities using cases and also delved into norms
governing some societies as regards paternity. It
was discovered that there are more paternity than
maternity disputes. This research will be relevant to
legal practitioners, families, community leaders and
the general public as a whole. It is recommended
that families should resort to DNA tests early
enough to avoid the emotional trauma that
accompanies paternity disputes
Stability Analysis of a Structural Element (Plate), Subjected to External Load.
Authors: Uzoukwu S. C Uzoukwu S. C , Ibearugbulem M. O Ibearugbulem M. O , Njoku F. C Anyaogu L , Ikpa P. N Ikpa P. N , Nwokorobia G.C. Nwokorobia G.C.
Published: February 2025

A plate of Clamped Clamped
Fixed Fixed orientationt, whose vertical axis rest
on clamped and fixed supported edges while the
horizontal axis rests on also clamped and fixed
boundaries, forming a plate of CCFF shape
orientation, remains the plate of focus in the work.
Third order energy Functional was adopted in the
research work. The clamped clamped fixed fixed
plate was considered as the direct independent
plate, meaning that the material properties are
uniform round about the shape of the element.
These includes the flexural rigidity, poison ratio
and young elastic modulus of elasticity.
Considering the plate arrangement, the shape
functions were first formulated, after which the
various integral values of the differentiated shape
functions, of the various boundary conditions were
all generated. Next to this was the formulation of
the stiffness coefficients for the various boundary
cases. Further minimization yielded the controlling
functional known as the overall potential energy
functional. The differential value of the Third
Order Overall Potential Energy Functional, with
respect to the amplitude was further integrated. The
integration gave rise to the result known as the
Lead equation. From the lead equation comes the
derivation of the non-dimensional buckling load
parameters. The rest of the analysis which is
detailed below was conducted using the buckling
equation
KESESUAIAN EKOWISATA MANGROVE DI WILAYAH PESISIR DESA SONSILO KECAMATAN LIKUPANG BARAT KABUPATEN MINAHASA UTARA
Authors: Marpaung Renaldy Alexander , Mantiri Desy M. H. , Rumengan Antonius P. , Kumampung Deislie R. H. , Djamaluddin Rignolda , Darwisito Suria
Published: February 2025

Mangrove adalah pepohonan atau komunitas tumbuhan tingkat tinggi yang tumbuh di garis pantai yang mempengaruhi pasang surut air laut. Kawasan mangrove menjadi sumber daya alam dan dapat dikembangkan dengan kegiatan ekowisata yang bertanggung jawab terhadap kelestarian alam dan memberikan manfaat ekonomi serta kebutuhan budaya bagi masyarakat dalam menjaga kelestarian mangrove. Tujuan Penelitian ini mengetahui nilai indeks kesesuaian parameter di Desa Sonsilo. Penelitian ini dilakukan melalui pengumpulan data primer dan sekunder. Data primer dan sekunder diperoleh di lapangan, meliputi kerapatan mangrove, ketebalan mangrove, jenis mangrove, objek biota, dan data sekunder pengambilan data pasang surut. Teknik pengumpulan kerapatan mangrove menggunakan line transect pada setiap transek yang diamati tarik terlebih dahulu garis transek dengan panjang 100 m dan setiap transek akan diberikan jarak 50 m, pada setiap garis diberikan sebanyak 5 plot, kemudian dalam setiap plot diberikan ukuran 10x10 m. Hasil nilai rata-rata paramaeter kesesuaian ekowisata pada ketebalan mangrove rata-rata di Desa Sonsilo 535,25 m. jumlah pada individu mangrove yaitu 8 spesies Avicennia marina, Bruguiera gymnorrhiza, Ceriops tagal, Nypa fruticans, Rhizopora apiculata, Rhizopora sp., Sonneratia alba, Xylocarpus sp. pada objek biota asosiasi terdapat ikan, udang, kepiting, moluska dan burung, dan nilai rata-rata pasang surut 0 - 1 m.
Kata Kunci: Desa Sonsilo, Ekowisata, Mangrove, Kepadatan, Ketebalan
Analytical evaluation of output gain in photovoltaic-thermoelectric tandems
Authors: Sakuma Jun , Kamide Kenji , AKIYAMA Hidefumi
Published: February 2025

We analytically derived general requirements for photovoltaic (PV)–thermoelectric (TE) tandems gaining efficiencies beyond those of the original PV cells, and evaluated their output gain. We compared the derived gain-requirements equations with data of reported PV cells and TE devices, and showed that gain is practically possible with GaAs and thin c-Si PV cells in PV-TE generator (TEG) tandems but not in PV-TE cooler (TEC) tandems. We showed that combinations with BiTe TEGs can improve the efficiency of practical GaAs PV cells from 24% to 28.4% and that of ideal GaAs PV cells from 33% to 34.6%.
Brand Positioning Strategy and Consumer Knowledge: Its Impact on Brand Attitude and Purchase Decision
Authors: Ruchiat Nugraha Aat , Fatma Sjoraida Diah
Published: February 2025

This study analyses the impact of brand positioning strategy and consumer knowledge on brand attitude and purchase decisions. In today’s highly competitive business environment, companies must develop effective marketing strategies to influence consumer attitudes towards brands, ultimately affecting their purchase decisions. Two key factors in this process are precise brand positioning and consumer knowledge of the brands and products they choose. This research employs a quantitative approach with path analysis to identify direct and indirect effects among these variables. Primary data were collected through an online survey distributed to 250 respondents who had purchased electronic products in Indonesia within the past six months. The results of multiple regression analysis indicate that brand positioning (β = 0.52) and consumer knowledge (β = 0.41) significantly influence brand attitude. Additionally, brand attitude significantly affected purchase decisions (β = 0.65). Mediation tests further reveal that brand attitude mediates between brand positioning, consumer knowledge, and purchase decisions. These findings provide valuable insights for companies to design more effective marketing strategies by strengthening brand positioning and enhancing consumer knowledge, ultimately positively impacting purchase decisions. Firms must ensure that these three elements—precise brand positioning, in-depth consumer knowledge, and a positive brand attitude—are well-integrated into their marketing strategies to achieve optimal outcomes.
Impact of Serum 25-Hydroxyvitamin D Deficiency on Arterial Stiffness in Non-Dialysis CKD Patients
Authors: Faruq Dr. Md Omar , Juthy Dr Shanjida Sultana , Akbar Dr. Romana , Hossain Dr. Md Saeed , Hore Dr. Borsha Tithi , Hasan Dr. Md Farucul
Published: February 2025

Introduction: Chronic Kidney Disease (CKD) is a major global health issue, with an increasing prevalence in Bangladesh. It is associated with numerous complications, especially cardiovascular diseases, which are the leading cause of morbidity and mortality among CKD patients. Arterial stiffness, a key cardiovascular risk factor, has been shown to correlate with CKD progression. Recent studies suggest that serum 25-hydroxyvitamin D (25(OH)D) deficiency plays a significant role in the development of arterial stiffness and cardiovascular complications in CKD patients. Objective: This study aims to investigate the impact of serum 25-hydroxyvitamin D deficiency on arterial stiffness in non-dialysis CKD patients in Bangladesh. Methods: A cross-sectional observational study was conducted at the Department of Nephrology, Dhaka Medical College, between September 2021 and March 2023. A total of 100 non-dialysis CKD patients (Stages 3-5) were enrolled, with 50 patients each in the vitamin D deficient and non-deficient groups. Arterial stiffness was measured using established methods, and serum 25(OH)D levels were assessed. Statistical analysis was performed using SPSS version 26.0, with significance set at p<0.05. Results: The study found that 78% of patients in the vitamin D deficient group were in Stage 5 CKD, compared to 12% in the non-deficient group. A significant negative correlation was observed between serum 25(OH)D levels and arterial stiffness (r = -0.386, p = 0.001). Laboratory variables such as eGFR and hemoglobin levels were significantly lower in the vitamin D deficient group (p<0.05). Conclusion: The study concludes that vitamin D deficiency plays a critical role in the pathogenesis of arterial stiffness in CKD patients. Addressing vitamin D deficiency may offer potential benefits in mitigating cardiovascular complications and improving the prognosis of CKD patients in Bangladesh.
Comorbidities And Risk Factors For COVID-19 In A Group Of Iraqi Patients Confirmed By Real-Time PCR Test
Authors: Mahmood M. K. , Saleh E. S. , Mahmood Ghassan M.
Published: February 2025

Coronary artery disease (CAD) is a major global contributor to mortality and morbidity. Genetic susceptibility plays a significant role in its etiology, particularly when CAD occurs prematurely. However, the relationship between premature CAD (PCAD) and specific genetic polymorphisms in the Iraqi population is still unclear. This aim of this study to assess the relationship between the KALRN gene single nucleotide polymorphism (SNP) (rs9289231T>G) and the development of PCAD in Iraqi patients. It also assesses the potential of serum Kalirin protein levels as a biomarker for PCAD. The study included 92 participants divided into two groups. Polymerase chain reaction (PCR) was performed to detect the KALRN SNP (rs9289231T>G), and the PCR products were analyzed via Sanger sequencing. Kalirin protein serum levels were measured using the ELISA technique. An association with statistical significance was found between the frequencies of genotypes and alleles of the KALRN SNP (rs9289231T>G) among the study groups, following a dominant genetic model. There was also a relationship between the genotypes of the KALRN SNP and CAD severity. Kalirin serum levels were significantly elevated in participants with CAD and were associated with the KALRN SNP genotypes. The KALRN SNP (rs9289231T>G) is associated with premature CAD in the Iraqi population, and follows a dominant genetic model. Elevated Kalirin serum levels, linked to the presence of the mutant allele, may serve as a biomarker for early diagnosis of the disease.