bluuebunny/crossref_metadata_2025 huggingface dataset:
Tinjauan Yuridis Persyaratan Permohonan Penerbitan Paspor Terhadap Anak Yang Lahir Dari Orangtua Stateless Di Indonesia
Authors: Kansil Oktinardo Mandira Dulage
Published: June 2023

Etnis Rohingya datang ke Indonesia sebagai pencari suaka dimana status mereka adalah stateless person. Apabila para pencari suaka memiliki anak yang lahir di Indonesia, berdasarkan pasal 4 huruf i dan k Undang-Undang Nomor 12 Tahun 2006, anaknya merupakan Warga Negara Indonesia, tetapi tidak ada bukti tertulis berupa dokumen kependudukan yang dapat diperoleh bagi anak dari orang tua berstatus stateless person. Dengan tidak adanya bukti tertulis, berakibat pada tidak dimungkinkannya menerbitkan paspor bagi anak, padahal kepemilikan paspor merupakan salah satu hak bagi seorang warga negara. Penelitian ini menggunakan metode normatif, yaitu mengkaji ketentuan-ketentuan hukum dan menarik asas-asas hukum yang ada dalam masyarakat serta apa dampak dan akibat yang timbul dari ketentuan hukum tersebut dalam kehidupan masyarakat. Dari undang-undang maupun peraturan-peraturan pendukung undang-undang dapat terlihat bahwa di Indonesia sudah diatur mengenai status kewarganegaraan anak dari orang tua berstatus stateless person tetapi tidak ada aturan dalam bentuk undang-undang ataupun peraturan lain yang mengatur mengenai bentuk dokumen tertulis kependudukan atau kewarganegaraan untuk kondisi seperti ini. Tidak adanya dokumen tersebut maka prosedur penerbitan paspor tidak dapat terpenuhi sehingga pemenuhan hak seseorang untuk memiliki paspor tidak dapat dilakukan.
Penerapan Kepatuhan Syariah Pada Jual-Beli Dropshipping Fashion Di Marketplace Frozenshop.Com
Authors: Aldabena Muhamad Reyhan
Published: June 2023

Sharia compliance broadly is the application of Islamic principles, sharia and its traditions in financial and banking transactions as well as other related businesses, sharia compliance applies in Indonesia in accordance with the Fatwa of the National Sharia Council (DSN) because the DSN fatwa is the embodiment of sharia principles and rules that must be adhered to. adhered to, including in business matters such as dropshipping. Dropshipping is a buying and selling system involving 3 parties, namely buyers, sellers and suppliers (providers of goods). The seller in this context is referred to as a dropshipper. Frozenshop.com is one of the men's fashion suppliers in Indonesia that they open opportunities for dropshippers to sell their goods back to consumers.

The purpose of this study is to find out how the implementation of sharia compliance in the sale and purchase of dropshipping fashion in the Frozenshop.com Marketplace and how the legal implications of the dropshipping fashion sale and purchase scheme in the Frozenshop.com Marketplace online which still contain elements of gharar. The results of this study are the application of sharia compliance in the sale and purchase of dropshipping fashion in the Frozenshop.com marketplace is not in accordance with sharia compliance, where the goods are not owned directly by the dropshipper when the dropshipper sells the goods. Meanwhile, the Legal Implication for the dropshipping fashion sale and purchase scheme in the online Frozenshop.com marketplace which still contains an element of gharar, is a dropshipping sale and purchase scheme with goods that have not obtained permission from Frozenshop.com which acts as a supplier. So the legal implications of buying and selling goods sold by the dropshipper are canceled or Faskah.
A Teacher's Code-Switching In English Classroom
Authors: Khairunnisa Sri Kinanti , Izzah Lidiyatul
Published: June 2023

This study aims to look into different the types of code-switching that the teacher employs when teaching English at Al-Hidayah Boarding School and the function of the teacher's code-switching on English learning at Al-Hidayah Boarding School. This writer has conducted this study through a qualitative method with a case study design. An English teacher is a subject in this study. The writer has collected the data using observation and interview instruments. The results of the data analysis showed that the use of code-switching by the teacher in English teaching at Al-Hidayah Boarding School occurred in a total of 199 cases; (1) intra-sentential code-switching occurred 88 times, (2) inter-sentential code-switching 76 times, and (3) tag code-switching occurred 35 times. The function of code-switching used by the teacher found three functions; Topic switch, affective function, and repetitive function. The teacher used code-switching mostly to assist him in conveying material with repetitive functions to avoid misunderstandings.
Rancangan Screening Anak Berkebutuhan Khusus Pada Insan Mandiri Homeschooling
Authors: Ni Wayan Ari Ayu Astiti Ni Wayan Ari Ayu Astiti , Wiriana Wiriana , Retnoningtias Diah Widiawati
Published: June 2023

The differences between Children with Special Needs (ABK) and children are generally seen from physical, intellectual, emotional, mental, and social differences. This study aims to design  a screening  tool for children with special needs as an effort to recognize whether a child has special needs or not, as a basis for placement and making individual learning programs at Insan Mandiri Homeschooling.  The type of research used is Research and Development (R&D) level 1. Data collection techniques use interviews, questionnaires, and documentation. This research only tests the internal validity of judgement  experts by experts and practitioners. The results of the interview showed that  the screening  design consisted of a cover page, foreword, table of contents, procedures for implementation and scoring, child identity, family structure, identification goals, medical history, parenting, social environment  of the child concerned, a checklist of child development from the age of 2-17 years including physical, cognitive and language development, and psychosocial. The five aspects of assessment are the content or material aspect, the linguistic aspect, the integration aspect, the presentation aspect, and the graphic aspect. As for the assessment results from experts and practitioners, it shows that all components of the value are more than 75, meaning that all aspects of the assessment are valid. There are three things that must be corrected, namely that each statement can be made more specific according to age level, language simplification in cognitive development systems, and typing errors. In conclusion, the  design of identification tools that are compiled based on the results of interviews in order are the cover page, foreword, table of contents, procedures for implementation and scoring, identity of the child, family structure, purpose of identification, medical history, parenting, social environment of the child concerned, checklist  The development of children from the age of 2-17 years includes physical, cognitive and language development, respectively, as well as psychosocial. The creation of each aitem considers developmental theories as well as pre-existing child development test kits.
Pengelolaan Ruang Bawah Tanah Dalam Reformasi Hukum Pertanahan Di Indonesia
Authors: Atlanta Nur Nafa Maulida , Anggono Bayu Dwi , Setyawan Fendi
Published: June 2023

The difficulty of obtaining or using the earth's surface in urban areas has resulted in people starting to look for a number of plots of land below the earth's surface. Thus, a development breakthrough innovation is needed that can address the development of community needs, namely the space below the earth's surface. The use of basements, namely UUPA, automatically refers to property rights in discussing the use of basements. The aim is to find a system for granting land rights or management rights to basements in Law Number 5 of 1960 concerning Basic Agrarian Regulations and Law Number 11 of 2022 concerning Job Creation for individuals. This research is a normative juridical research with collection techniques from the literature which consists of primary and secondary legal materials. The results of this study are the system of granting land rights or management rights to basements in the BAL by basing it on the provisions of Article 2 paragraph (2) of the BAL, the term "management" and "organizes". The Job Creation Law is for individuals or legal entities that are given HGB and HP for a period of time as contained in the concept of basement management in Article 146 paragraph (1) to (5) of the UUCK, namely paragraph (1) The land or space formed in the upper room or underground and used for certain activities can be given HGB, HP, or HPL. In conclusion, the State Authority relates to (a) the use and/or allotment, supply and maintenance of the earth, air, space and natural resources in the territory of the Republic of Indonesia; (b) payment or arrangement of types of land rights; (c) paying or arranging several legal relations between people and legal entities with land as objects.
Menumbuhkan Minat Literasi Generasi Menghadapi Tantangan Zaman Dalam Perspektif Al-Qur’an
Authors: Hizliah Siti
Published: June 2023

The millennial generation is a modern generation that has one of the characteristics of a consumptive lifestyle. Apart from the consumptive lifestyle of the millennial generation, it is also a technology-based life. The purpose of the research conducted is to foster a high interest in reading in facing the challenges of modern life. The research method used isthe analysis method. Research methods used in solving problems include analytical methods. The image caption is placed as part of the image title (figure caption) instead of being part of the image. The methods used in completing the study are written in this section.  The results and discussions of the millennial generation are a social construction in which there is a group of people who have the same age and experience the same history. Individuals who belong to a generation, are those who have the same year of birth in a span of 20 years and are in the same social dimension and historical dimension. Conclusion In the process of educating and fostering children is inseparable from various efforts and efforts, of course we as parents and educators will always provide the best education.
Pengaruh Temuan SPI, Temuan Kepatuhan, Tindak Lanjut Hasil Pemeriksaan dan Penyelesaian Kerugian Daerah Terhadap Opini Audit di Kabupaten/Kota Provinsi Sumatera Selatan
Authors: Valentina Jessica Valentina
Published: June 2023

This study aims to determine the effect of SPI findings, compliance findings, follow-up inspection results and settlement of regional losses on audit opinions in districts/cities of South Sumatra province. The type of research used in this research is quantitative research using secondary data obtained from the official website www.bpk.go.id and requests for data on inspection reports to the BPK RI head office. The population used in this study were all districts/cities in the province of South Sumatra, namely 17 districts/cities with a total of 85 samples. The sample selection used the saturated sample method, which is a sampling technique when all members of the population are used as samples. Testing this hypothesis using Logistic Regression analysis with T test, F test, and the coefficient of determination. The data were analyzed with the help of SPSS version 26 software. The results of this study indicate that partially the Compliance Findings have a negative and significant effect on Audit Opinion. Meanwhile the SPI Findings, Follow Up on Audit Results and Settlement of Regional Losses have no and no significant effect on the Audit Opinion. Simultaneously SPI Findings, Compliance Findings, Follow-up on Examination Results and Settlement of Regional Losses have a positive and significant impact on Audit Opinion in the Regency/City of South Sumatra Province.
Pengaruh Kinerja Keuangan Daerah Terhadap Belanja Modal pada Kabupaten/Kota di Provinsi Sumatera Selatan
Authors: Devi Annisa Sarina , Masnila Nelly Masnila , Nurhasanah Nurhasanah Nurhasanah
Published: June 2023

Belanja Modal merupakan pengeluaran pemerintah yang bisa dirasakan oleh masyarakat dan memiliki masa manfaat lebih dari satu periode. Penelitian ini bertujuan untuk mengetahui pengaruh Kinerja Keuangan terhadap Belanja Modal di Kabupaten/Kota Provinsi Sumatera Selatan Tahun 2016-2020. Penelitian ini menggunakan pendekatan kuantitatif dan sumber data sekunder dimana data tersebut diperoleh melalui Badan Pemeriksa Keuangan Provinsi Sumatera Selatan. Populasi dalam penelitian ini adalah 17 Kabupaten/Kota dengan sampel jenuh. Total data observasi yaitu 85 Laporan Realisasi APBD Kabupaten/Kota Provinsi Sumatera Selatan. Pengujian hipotesis ini menggunakan regresi linier berganda dengan uji t, uji F, dan koefisien determinasi. Data dianalisis dengan bantuan software SPSS versi 26. Hasil dari penelitian ini menunjukkan bahwa secara parsial Pertumbuhan Keuangan Daerah berpengaruh positif signifikan terhadap Belanja Modal, Derajat Desentralisasi berpengaruh negatif signifikan terhadap Belanja Modal. Efisiensi Keuangan Daerah berpengaruh positif signifikan terhadap Belanja Modal. Sementara Efektivitas PAD dan Ketergantungan Keuangan Daerah tidak berpengaruh signifikan terhadap Belanja Modal. Secara simultan Pertumbuhan Keuangan Daerah, Derajat Desentralisasi, Efisiensi Keuangan Daerah, Efektivitas PAD, Ketergantungan Keuangan Daerah berpengaruh signifikan terhadap Belanja Modal di Kabupaten/Kota Provinsi Sumatera Selatan.
Filsafat Ilmu dan Ilmu Pendidikan
Authors: Marlinton Melisa Marlinton , Herlina Herlina Herlina , Suraidah Suraidah Suraidah , Puspita Yenny Puspita , Efendi Darwin Efendi
Published: June 2023

Philosophy is the study of the nature of things, such as humans, nature, and God. Philosophy is seen as a humanizing process so that humans are able to develop and actualize themselves with all the original potential that exists within themselves. Education develops from curiosity, curiosity, and the desire to seek reality which is a characteristic of humans. Education is a special human effort to express reality, in order to enable humans to socialize with each other, build dialogue by acknowledging other people, and increase their human dignity. Philosophy is an inseparable part of educational practice, but the existence of this philosophy seems to have begun to be abandoned. Considering that philosophy is an inseparable part of education, this paper attempts to reaffirm the relationship between philosophy and education. The method used to determine the relationship between philosophy and the author's education is to study literature. Based on the results of the study of literature clearly shows the relationship between philosophy and educational practice as in curriculum formulation and educational theories.
Pengujian Perangkat Lunak Menggunakan Metode Regression Testing pada Aplikasi Pembelajaran Matematika untuk Siswa Tingkat Smp Berbasis Android
Authors: Luginawati Syita , Wahyu Ari Purno
Published: June 2023

Technological developments have caused several significant changes in the world of education. One of them is as a learning media. Currently, students at every level of education are familiar with the use of devices as learning media. Through technology, it is easier for them to access every material so that it is easier to learn it. As a result, learning media applications that can be used in students' mobile devices to facilitate their activities are increasingly being loved lately. However, applications with various features and advantages will certainly leave gaps in application vulnerabilities and other errors. Therefore, this study aims to determine the readiness of the application when used in bulk and minimize errors that occur to maintain the integrity of the application so that it can be used properly by users using the Regression Testing method. In this study the application used was the Mathematics Learning Application for Android-Based Middle School Level Students.
Penguatan Disain Organisasi dalam Sistem Inovasi Daerah (SIDA) Pasca Covid19 Kabupaten Bandung Barat Propinsi Jawa Barat
Authors: Bustomi Thomas
Published: June 2023

Development of leading sectors through innovation in increasing the competitiveness of leading business sectors. In this study, information was obtained that the West Bandung Regency government had difficulty determining priority leading sectors after the COVID-19 pandemic, where in determining sectoral leading sectors and the need to identify innovation needs in priority leading business sectors. The data collected includes secondary data and primary data through survey interviews and field observations to identify leading sectors through Location Quotient (LQ), Localization Index (LI) and Shiftshare analysis. Based on the analysis, it is obtained that the sectors that have fast growth with high competitiveness are the Education Services sector. Communication, Corporate Service Sector, Health Service Sector and Social Activities and Other Services. In these sectors that have fast growth but need improvement in order to have good competitiveness, it is necessary to have a pattern of relations between various sectors from an innovation system developed through organizational design to map out the process of developing policy relations in and the creation of institutional structures that complement each other in acceleration of West Bandung Regency RPJMD.
The Role Of NGO In Ecotourism Development In The Bukit Lawang Tourism Village Plantation, North Sumatra
Authors: Lubis Muhammad Rizki
Published: June 2023

This study examines and analyzes the participation of NGOs in tourism development in Bukit Lawang Tourism Village Plantation. This study used a descriptive-qualitative method with data collection tools in the form of observation and interview. The results of this study describe that the role of NGOs in developing ecotourism in Bukit Lawang has been carried out by Project Wings by carrying out activities that have succeeded in collecting 325 kg of waste. The Kelas Hijau Institute has also conducted weekly class activities which are held every week for around 60 to 100 local children or classes about the environment and English education for children aged 5 to 12 years. At the Environmental Center stage, they have a contribution in providing information and building cooperation with community protection in efforts to conserve and manage the environment wisely as well as advocating for environmental preservation. The success of the role of NGOs in tourism development is also influenced by the appropriate expertise in terms of quality, honesty and consistency of each party involved.
Identification Of The Hierarchy Of Ecotourism Criteria Using The AHP Method: Reference For Determining Priority Villages For Ecotourism Development
Authors: Prasandya Km. Deddy Endra , Satria Made Wina
Published: June 2023

The existence of government programs that change the direction of tourism development from mass tourism which is considered to cause degradation of environmental, socio-economic and cultural aspects, to quality tourism, is also a concern for Bali tourism leaders to participate in efforts to change the direction of Bali tourism development through the development of ecotourism. The proof is that many studies/research have been conducted to add new forms of more sustainable tourist destinations in Bali. The study concluded that many villages in Bali have the potential to be developed as ecotourism. The focus of this research is to formulate a hierarchy of criteria for ecotourism development using the AHP (Analytical Hierarchy Process) method. The hierarchy of ecotourism development criteria can be used as an indicator to assess the next ecotourism priority village. This research is a mixed method research, where identification and weighting will be carried out through the Decision Support System (SPPK) with the AHP method. Secondary data collection in the form of research that has been carried out previously and supporting literature related to ecotourism is used to formulate criteria and sub-criteria for ecotourism development. This formulation is used as initial information in the process of weighing ecotourism criteria and sub-criteria. The results showed that there are six ecotourism criteria that can be used in determining priority villages for future ecotourism development including environmental criteria (absolutely more important: 0.281), socio-cultural (0.210), level of community participation (0.168), education (0.166), economy (0.100), and institutional (0.075).
Karakteristik Daging Sapi Bali yang Diberi Asap Cair dengan Lama Perendaman dan Lama Penyimpanan yang Berbeda
Authors: Nursayang Siti , Hardianti Hardianti
Published: June 2023

Asap cair bisa menjadi pilihan sebagai bahan pengawet alami pengganti formalin dan borax yang dapat digunakan untuk pangan maupun non-pangan karena memiliki sifat antimikroba dan antioksidan. Daging asap diperoleh dari proses pengasapan yang dihasilkan dari pembakaran kayu tertentu dengan maksud untuk memberikan kesempatan kepada gas-gas hasil pengasapan bisa masuk ke dalam daging. Penelitian ini bertujuan untuk mengetahui kualitas (mikrobiologi, kimia, fisik, organoleptik) daging yang diberi asap cair dengan lama perendaman dan lama penyimpanan yang berbeda. Penelitian ini disusun berdasarkan rancangan acak lengkap (RAL) pola faktorial 4 x 4 yang diulang sebanyak 3 kali. Faktor A : lama perendaman (2, 3, 4, dan 5 jam) dan faktor B : lama penyimpanan (0, 7, 14, dan 21 hari). Peubah yang diamati : pH daging, daya ikat air (DIA), uji total bakteri (TPC), dan  uji organoleptik yang meliputi, kebasahan (juiciness), keberadaan sisa pengunyahan (residu), dan aroma. Lama perendaman menunjukkan pengaruh nyata (P<0.05) terhadap pH, DIA, persepsi kebasahan, persepsi keberadaan residu, persepsi aroma daging sedangkan lama penyimpanan menunjukkan berpengaruh nyata (P<0.05) terhadap pH, jumlah bakteri (nilai TPC), persepsi keberadaan residu, dan persepsi aroma daging.   Terdapat interaksi lama perendaman dan lama penyimpanan terhadap persepsi kebasahan (juiciness), persepsi keberadaan residu dan persepsi aroma daging.
Role of Urinary Screening Programmes in Children in the Prevention of Chronic Kidney Disease
Authors: Yap HK , Quek CM , Shen Q , Joshi V , Chia KS
Published: June 2023

Introduction: This article reviews published literature on the usefulness of population-based urinary screening in the Asian paediatric population. Methods: Articles were found in the Medline database using the key words “paediatrics”, “urine screening”, “proteinuria”, “haematuria” and “population”. The Asian countries which had carried out population-based urinary screening of the paediatric population included Taiwan, Japan and Korea. One study was found on urinary screening in a select population in Malaysia. Preliminary results of the urinary screening of school children in Singapore are presented and compared with the results found in the above-mentioned countries. Results: Overall, the proportion of children found to have urinary abnormalities ranged from less than 0.1% of the population screened to almost 50% of a select cohort referred from the screening programmes for the evaluation of urinary abnormalities. In the pilot Singapore school screening programme, the prevalence of clinically significant proteinuria was 1.25 per 1000 children screened. Multivariate analysis showed that low body weight was associated with a 1.8-fold greater risk for proteinuria. The major cause of haematuria and proteinuria in those studies where renal biopsies were performed was glomerulonephritis. The Taiwanese experience also showed a reduction in the incidence of end-stage renal failure diagnosed in children after the onset of urine screening. Conclusion: These studies showed that urinary screening programmes in school children allow the early detection of disease. The cost-benefit ratio for specific populations should be determined before the implementation of such programmes.
From the Pandemic to Restructuring to Disruptive Corporate Behavior: 2023 as the Inevitable Year of Efficiency
Authors:   Associate Professor of Management, Ohio Northern University James F. Dicke College of Business Administration, 218 Dicke Hall , Ada, Ohio 45810, Savino David M.
Published: June 2023

Joseph Schumpeter’s concept of creative destruction is being put to the test as each month of 2023 passes with the process of economic evolution and recreation being witnessed as a rapid pace of change is upon us. Mark Zuckerberg’s pronouncement of 2023 as the year of efficiency was not a prediction but rather a description of the events that have unfolded in the Tech industry that has also spilled over to other key economic sectors. Are we seeing a normal evolution of the development of the next phase of economic realities or a major upheaval of the system to correct decisions and actions of the past that were ill conceived and executed? This study is an attempt to accurate identify this unique economic phenomenon this has been occurring since Spring of 2022.
Military Geography in Determining the Socio-Economic Improvement in the Foremost Island for Developing the Integrated Military Bases
Authors:   Republic of Indonesia Defense University, Bogor-Indonesia, Asmoro Novky , Navalino Djoko Andreas ,   Republic of Indonesia Defense University, Bogor-Indonesia
Published: June 2023

The role of geography in the military strategy decision-making process has a significant position. This is inseparable from the development of technology that supports geography, such as the use of Unmanned Aerial Vehicles (UAVs) or drones, geospatial information-based weaponry and efforts to develop military bases based on the strategic location of a place. The purpose of this study is to analyze (1) The projection of the government's plan to develop Selaru Island as an integrated military base based on military geography (2) The social and economic impacts of the community that need to be anticipated when an integrated military facility is established related to economic growth, inflation and unemployment rates. The data in this study were analyzed using qualitative methods obtained as a result of in-depth interviews, observations, library research and focused group discussions. This study indicates that analysis of military geography and geospatial information is very much needed by the Indonesian Armed Forces (TNI) in developing its capabilities, especially in strengthening national defense system comprehensively. Therefore, the results of this study recommend the relocation and capacity building of several TNI bases around the island of Selaru so that national defense and economic growth can strengthen together in the foremost islands of the Republic of Indonesia.
An Empirical Study on the Premium of Low-Priced Stocks in China's A-Share Market
Authors: Liu Huizheng , Han Xinyao , Zhou Jiaqi , Ma Yidan , Yin Hang
Published: June 2023

Abstract

This paper selects the data of China's A-shares from 2001 to 2020 to study the premium effect of low-cost stocks in China's A-share market from different sectors using multiple regression analysis. The research results show that there is a premium effect of low-cost stocks in each sector of the A-share market. The increase in the shareholding ratio of institutional investors and the attention of analysts can reduce the premium effect of low-cost stocks.

JEL classification numbers: F832.5
Keywords: Low-priced stocks, Premium effect, Excess return, Financial anomalies.
The use of the combined vector vaccine GamCOVID-Vac (Sputnik V) in patients with immuno-inflammatory rheumatic diseases: safety issues-news
Authors: Kulikov A. N. , Muravyeva N. V. , Belov B. S. , Glukhova S. I.
Published: June 2023

The aim of the study was to assess the safety of the combined vector vaccine Gam-COVID-Vac (Sputnik V) and to determine the risk factors for the development of adverse events in patients with immuno-inflammatory rheumatic diseases (IIRD). Patients and methods. A single-stage study of patients with IIRD who were on inpatient treatment or who applied to the consultative and diagnostic center of the V.A. Nasonova Research Institute of Rheumatology was conducted, who received both components of the Sputnik V vaccine. The control group included immunized persons without IIRD. All participants were interviewed by a research doctor with filling out a unified questionnaire, additional information was obtained from medical documentation. Results. The study included 325 patients with IIRD and 138 healthy controls. After vaccination with the first component, the number of patients with IIRD, in whom the development of local and systemic adverse events (AEs) was noted, was significantly lower compared to the control (20.3% and 38.4% respectively; p<0.001). These differences also persisted after immunization with the second component (12.3% and 28.3% respectively, p<0.001). After complete vaccination, no AEs were documented in 40.3% of patients and 22.5% of the control group (p<0.001). Female sex and, possibly, methotrexate therapy increases the risk of developing local and systemic AEs on the first component of the vaccine, rituximab therapy - on the second. A lower incidence of AEs is typical for elderly patients, patients with a disease duration of more than 10 years and obesity. Exacerbation of IIRD was registered in 1 (0.3%) case, the occurrence of new autoimmune phenomena was not observed. Conclusions. According to the data obtained, the use of Gam-COVID-Vac (Sputnik V) in patients with IIRD is safe.
Cardiovascular manifestations of systemic lupus erythematosus: the significance of heart failure
Authors: Karateev R. A.
Published: June 2023

The involvement of the cardiovascular system is a typical manifestation of systemic lupus erythematosus (SLE), which determines the high level of mortality and disability of patients. A serious clinical problem is the development of heart failure (HF), which frequency in SLE is 3–4 times more than in the population. The development of this pathology is a complex process that occurs under the influence of systemic autoimmune inflammation and associated with heart damage (pericarditis, myocarditis, endocarditis, сcoronary artery disease, myocardial infarction), disorders of the cardiac conduction system (various arrhythmias), atherosclerosis, arterial hypertension, pulmonary hypertension, thrombosis against connected with bleeding disorders (especially associated with antiphospholipid syndrome), traditional risk factors, as well as the negative effect of anti-rheumatic therapy. Mostly HF in SLE occurs in a subclinical form with a preserved ejection fraction, and is detected using instrumental methods in more than 60% of patients. The management of patients with SLE and HF requires early diagnosis of this pathology, to do this, various diagnostic methods are used (particularly, echocardiography with speckle tracking imaging technique) and the identification of biomarkers such as NT-proBNP. HF therapy in SLE patients is based on the maximal reduction o f the activity of the disease due to rational pathogenetic therapy, also the control of traditional risk factors – antihypertensive therapy, the use of statins and the prevention of arterial and venous thrombosis.
Vaccination of pneumococcal infection in patients with systemic lupus erythe matosus and antiphospholipid syndrome: experience of 6 years of use
Authors: Tarasova G. M. , Belov B. S. , Reshetnyak T. M. , Cherkasova M. V.
Published: June 2023

Infections remain one of the main causes of morbidity and mortality in patients with immuno-inflammatory rheumatic diseases. Objective – to study the efficacy, immunogenicity and safety of the 23-valent polysaccharide pneumococcal vaccine (PPV-23) in patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (AРS). Materials and methods. 91 patients were included in the study: 78 with SLE, of which 18 (23 %) – with secondary AРS, 13 – with primary AРS. 85 patients received immunosuppressive therapy, including 30 – genetically engineered biological drugs (bDMARD); 23 – anticoagulants. PPV-23 was administered subcutaneously, patients were observed for a year after vaccination. Results. Local reactions were observed in 49% of patients with SLE and secondary AРS, in 23% of patients with primary AРS. General reactions were noted in isolated cases, were short-term and did not require additional prescriptions. During the follow-up period, no exacerbations of SLE, relapses of thrombosis and thromboembolism associated with vaccination were detected; no development of new autoimmune diseases was registered. 10 (13%) patients with SLE were immunized against the background of high activity of the disease, no adverse reactions were recorded. In some patients, a transient increase in a-DNA and ANF was observed during the year without signs of exacerbation of the disease. 56% of patients with SLE and secondary AРS, 15.4% with primary AРS were “responders” to the vaccine. There was no negative effect on the immune response of the dose of GC >10 mg/day, age, duration and activity of the disease. With the treatment of bDMARD, a full-fledged vaccine response was recorded much less frequently than with standard therapy (38% and 67.4%, respectively; p=0.01). After vaccination, there was a significant decrease in the number of lower respiratory tract infections (LRTI) (p=0.0001), including community-acquired pneumonia (PN) (p=0.03) and acute bronchitis (p=0.04), ENT infections (p=0.001). In the treatment of rituximab (RTM), compared with belimumab (BLM), a greater number of LRTI was observed, mainly due to PN. After vaccination on RTM therapy, the number of INDP in general (p=0.008) and PN in particular (p=0.03) decreased, isolated cases of LRTI and ENT organs were recorded on BLM therapy. Within 4–6 years after vaccination, 30 patients with SLE retained the clinical effect of vaccination, while immunogenicity decreased to 18%. Conclusion. Safety, sufficient immunogenicity, and clinical efficacy of PPV-23 in patients with SLE and AРS have been shown. The use of bDMARD reduces the vaccine response. Immunization performed prior to or during treatment with bDMARD lasting <1 year increases the number of vaccine responders.
Hyperleptinemia as a marker of various phenotypes of obesity and overweight in women with rheumatoid arthritis and systemic lupus erythematosus
Authors: Kondrateva L. V. , Gorbunova Yu. N. , Panafidina T. A. , Popkova T. V.
Published: June 2023

Objective – to identify different phenotypes of overweight in women with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) based on body mass index (BMI) and serum leptin levels, as well as to determine the frequencies of various metabolic disorders, hypertension and cardiovascular complications in individual phenotypes. Material and methods. The study included 50 women with RA and 46 with SLE aged 18 to 65 years without a history of diabetes and fasting hyperglycemia. The concentration of leptin (ELISA), insulin (electrochemiluminescence analysis) was determined in all patients, and the HOMA-IR index was calculated. Hyperleptinemia was diagnosed at leptin concentrations >11,1 ng/ml, insulin resistance (IR) – at HOMA-IR values ≥2,77. Three main phenotypes of overweight were distinguished: “classic” (BMI≥25 kg/m2  + hyperleptinemia), “healthy” (BMI≥25 kg/m2 , without hyperleptinemia), “hidden” or “latent” (BMI<25 kg/m2  + hyperleptinemia), as well as “normal weight” (BMI<25 kg/m2 , without hyperleptinemia). Results. Patients with RA and SLE were similar in age (p=0.4), disease duration (p=0.2) and BMI (p=0.5). Hyperleptinemia was found in 46% of women with RA and 74% – with SLE (p=0.005), IR – in 10% and 22% of patients, respectively (p=0.2). The “classic” phenotype of overweight was diagnosed in 30%, “healthy” – in 8%, “hidden” – in 16% of cases with RA and in 44%, 0% and 30% of cases with SLE, respectively. IR was found in 3%, hypertension – in 6% of patients with “normal weight”. With the “classical” phenotype, IR (29%) and hypertension (66%) were more common than with “normal weight” (p<0.01 in all cases), with the “hidden” phenotype, significant differences were obtained only in hypertension frequency (45%; p=0.0012), but not IR (18%). 3 out of 4 women with a history of cardiovascular complications suffered from “classic” overweight, one patient had a “normal weight”. Conclusion. In women with SLE up to 65 years of age, the frequency of hyperleptinemia, but not IR, is higher than in patients with RA. In both diseases, the “classic” overweight phenotype is most common. In RA, a “hidden” phenotype was detected less often than in SLE, at the same time, a “healthy” phenotype is not characteristic of SLE. The frequencies of metabolic disorders and hypertension is low with the “normal weight” and “healthy” phenotype, high – with the “classic”, intermediate – with the “hidden” phenotype.
Rheumatic diseases as a reason for emergency hospitalization
Authors: Povzun A. S. , Mazurov V. I. , Shchemeleva E. V. , Povzun K. A. , Kovalchuk E. Yu. , Kostenko V. A.
Published: June 2023

The study of pain in the projection of joints occurrence is an important medical and social task, the solution of which makes it possible to determine the amount of necessary forces and means for the organization of medical care for these patients. For the first time in Russian Federation on the basis of Saint-Petersburg Research Institute of Emergency Care named after I.I. Dzhanelidze the concept of providing medical care to patients with pain in the projection of joints was introduced into clinical practice. The study of the prevalence of pain in the projection of joints data, places and roles of rheumatological diseases (RD) allows to outline ways to optimize diagnostic and therapeutic algorithms, reducing the time of diseases diagnosis and optimizing the inpatient stage of treatment duration. An increase in the proportion of patients referred to the outpatient stage allows rational use of specialized beds in the hospital and gives a significant economic effect for the healthcare system. RD are the second most common cause of pain in the projection of joints. Its average percentage of patients referred for hospitalization was 2.69% of the total number of patients in the Saint-Petersburg Research Institute of Emergency Care named after I.I. Dzhanelidze. The structure of the incoming flow of patients with pain in the projection of joints was analyzed, the nosological structure of patients with RD was evaluated. Osteoarthritis, rheumatoid arthritis and gouty arthritis are the leading causes of pain in the projection of joints.
Categorizing Molecular Features of Venom Toxins Using Bioinformatics Tools
Authors:   Walchand Centre for Biotechnology, Solapur, Maharashtra, India, Sinoorkar Vinod P , Shinde Pratiksha D ,   Walchand Centre for Biotechnology, Solapur, Maharashtra, India
Published: June 2023

Poisonous organisms are represented in many taxa, including kingdom Animalia. During evolution, animals have developed special organs for production and injection of venoms. Animal venoms are complex mixtures, compositions of which depend on species producing venom. The most known and studied poisonous terrestrial animals are snakes, scorpions and snails. Venomous animals produce a myriad of important pharmacological components. The individual components, or venoms (toxins), are used in ion channel and receptor studies, drug discovery, and formulation of insecticides. Knowing the key clinical applications of venom, the present investigation was carried out to understand the molecular basis of venom toxins of animals like snake (L-amino acid oxidases), cone snail (Contulakin-G) and scorpion (Chlorotoxin) by retrieving the protein sequence information, deducing various physicochemical properties, predicting secondary structural elements, homology modelling and depicting the potent antigenic regions using various bioinformatics tools and soft-wares. Because of their remarkable molecular diversity, venoms are key, albeit challenging, resource for pharmacological discovery that contribute to the development of drugs that act as anti-tumor agents, heart stimulants and therapies for neurological diseases. Venom-informatics is a systematic bioinformatics approach in which classified, consolidated and cleaned venom data are stored into repositories and integrated with advanced bioinformatics tools for the analysis of structure and function of toxins. Venom-informatics complements experimental studies and helps reduce the number of essential experiments.
Fatores de risco para o diagnóstico de leucemia linfoide aguda na infância: revisão de escopo
Authors: Severino Gabriele de Souza , Nepomuceno Isadora Fernanda Campos , Xavier Rangel Vinicius , Moreira Anna Clara Araújo , Patrocínio Thamirys Cristina , De Oliveira Grasiele Damas , Andrade Silmara Nunes
Published: June 2023

Introdução: A infância é um período de mudanças na vida do indivíduo, podendo influenciar na vida adulta. A leucemia linfoide aguda (LLA) possui alta incidência no público infantojuvenil e, na maioria dos casos, tem sintomas inespecíficos. Objetivos: Analisar os fatores de risco que podem ser identificados frente ao diagnóstico de leucemia linfoide aguda na infância. Métodos: Trata-se de uma revisão de escopo realizada no período de janeiro a março de 2022, utilizando por base de dados Biblioteca Virtual em Saúde e utilizando descritores previamente validados no Descritores em Ciências da Saúde. Resultados: Após a busca, 9 artigos foram selecionados para o respectivo estudo. Características socioculturais e genéticas foram apontadas como fatores de risco para diagnóstico da leucemia linfoide aguda na infância. Conclusão: Uma equipe capacitada capaz de identificar os fatores de risco para leucemia linfoide aguda é de extrema importância para um atendimento adequado e de qualidade.
PENDAMPINGAN PEMBIAYAAN POLA SYARI’AH BUMG KEUTAPANG UNIT USAHA SIMPAN
PINJAM KELOMPOK PEREMPUAN (SPP)
Authors: Nelliyana Nelliyana , Yusnidar Cut , Abdullah Husaini
Published: June 2023

Pembiayaan syariah merupakan kegiatan penyediaan uang dan barang dari
pihak bank pada pihak nasabah atas dasar persetujuan dan kesepakatan antara
pihak bank dan juga pihak yang dibiayai agar dapat mengembalikan uang
tersebut sesuai jangka waktu yang telah ditetapkan dengan memberikan imbalan
berupa bagi hasil. Bagi masyarakat Indonesia yang mayoritas adalah muslim,
pembiayaan syariah memang sangat membantu. Pasalnya, pembiayaan semacam ini
dinilai sudah mengikuti syariat islam dalam praktiknya sehingga dapat
mengurangi resiko riba. (Badan Usaha Milik Gampong) BUMG adalah badan hukum
yang didirikan oleh gampong guna mengelola usaha, memanfaatkan asset,
mengembangkan investasi dan produktivitas, menyediakan jasa pelayanan dan 
atau  menyediakan  jenis  usaha  lainnya  untuk  menciptakan  kesejahteraan 
masyarakat gampong. Sedangkan unit usaha BUMG adalah badan usaha milik
gampong yang melaksanakan bidang  usaha  tertentu.  BUMG  terdiri  dari  dua
 jenis  yaitu BUMG  Gampong  dan  BUMG Bersama.Kata kunci: Pembiayaan Pola
Syari’ah, Akad, Badan Usaha Milik Gampong (BUMG), Kelompok Simpan Pinjam
Perempuan (SPP).
SIFAT FISIK ULTISOL SETELAH LIMA TAHUN DI LAHAN KERING GLE GAPUI KECAMATAN INDRAJAYA KABUPATEN PIDIE
Authors: Handayani Sri , Karnilawati Karnilawati , Meizalisna Meizalisna
Published: June 2023

Tujuan dari penelitian ini adalah untuk mengetahui perubahan karakterisstik sifat fisik pada pengembangan kawasan penelitian lahan kering Glee gapui dari tahun 2016 sampai dengan tahun 2021. Penelitian ini dilaksanakan di Kebun Percobaan Fakultas Pertanian Universitas Jabal Ghafur Siglimulai dari bulan September sampai November 2020. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kuantitatif dengan menganalisis beberapa sifat fisik tanah. Hasil penelitian menunjukkan bahwa telah terjadi perubahan sifat fisik (tekstur, struktur, warna, kadar air, porositas, dan berat volume) pada Satuan Peta Lahan (4).Kata kunci: sifat fisik, lahan kering, ultisol
Kontribusi dan Trend Produksi Padi di Kabupaten Banyumas
Authors: Saputro Wahyu Adhi , Prasetyo Kunandar
Published: June 2023

Beras masih menjadi primadona sebagai pangan pokok masyarakat di Indonesia dengan begitu produksi padi menjadi kunci dalam penyediaan pangan. Provinsi Jawa Tengah menjadi salah satu lokasi yang memiliki produksi padi cukup baik terutama di Kabupaten Banyumas. Kontribusi produksi diperlukan untuk melihat seberapa besar sumbangsih wilayah terutama dalam menghasilkan padi. Prediksi produksi juga menjadi penting untuk melihat peluang produksi padi di masa mendatang. Penelitian ini bertujuan untuk menganalisis kontribusi dan trend produksi padi di Kabupaten Banyumas. Metode analisis data yang digunakan adalah analisis kontribusi dan analisis forecasting trend. Berdasarkan hasil penelitian didapatkan kesimpulan bahwa kontribusi produksi padi Kabupaten Banyumas dari tahun 2010 hingga tahun 2021 memiliki nilai positif. Arti dari penilaian tersebut menandakan bahwa produksi padi di Kabupaten Banyumas memiliki sumbangsih terhadap Jawa Tengah. Catatan kontribusi tertinggi berada pada tahun 2020 mencapai 4,11%. Berdasarkan trend produksi memiliki nilai positif yang mengindikasikan bahwa dalam beberapa tahun mendatang produksi padi di Kabupaten Banyumas akan meningkat. Berdasarkan kedua hasil tersebut harus didukung oleh pemerintah daerah untuk menjaga stabilitas produksi dengan berbagai langkah strategis seperti penyediaan bantuan sarana alat produksi dan paket teknologi.
PEMANFAATAN MULTIMEDIA INTERAKTIF DALAM MENINGKATKAN MINAT BELAJAR SISWA KELAS VIII PADA PEMBELAJARAN PKn DI MTS SABILIT TAQWA
Authors: Anwar Khairul , Jusrianto Jusrianto , Nur Haspidawati , Parubang Daniel
Published: June 2023

Artikel ini membahas tentang Pemanfaatan Multimedia Interaktif dalam Meningkatkan Minat Belajar Siswa Kelas VIII pada Pembelajaran PKn di MTs Sabilit Taqwa. Penelitian ini memfokuskan pada proses pembelajaran PKn dengan menggunakan media pembelajaran Multimedia Interaktif. Penelitian ini menggunakan pendekatan penelitian kuantitatif. instrumen pengumpulan data melalui oservasi, angket (kuisioner) dan dokumentasi. Analisis data menggunakan deskriptif. Pemanfaatan Multimedia Interaktif dalam Meningkatkan Minat Belajar Siswa Kelas VIII pada Pembelajaran PKn di MTs Sabilit Taqwa. Berdasarkan hasil penelitian yang telah dilaksanakan dapat disimpulkan bahwa pembelajaran PKn dengan menggunakan Media Pembelajaran Multimedia Interaktif dapat meningkatkan minat belajar siswa kelas VIII MTs Sabilit Taqwa dengan populasi jumlah 25 orang siswa. Berdasarkan hasil penelitian ini, peneliti menyimpulkan bahwa pemanfatan multimedia interaktif sangatlah efektif dalam meningkatkan minat belajar siswa kelas VIII/PKn di MTs sabilit taqwa. Hal ini didukung dengan nilai rata-rata siswa. Nilai rata-rata siswa pada tes awal adalah 71,84 lebih rendah dari pada tes akhir, 89,12. Selain itu, α lebih tinggi dari p-value (0,05 0,00). Hal ini menunjukkan bahwa hipotesis nol ditolak dan H1 diterima. Hal ini menunjukkan bahwa pemanfatan multimedia interaktif sangatlah efektif dalam meningkatkan minat belajar siswa kelas VIII/PKn di MTs sabilit taqwa
Penerapan Model Problem Based Learning Dalam Pembelajaran Materi Perbandingan Trigonometri
Authors: Lisade Eunike Priskila , Mangobi James Uriel Livingstone , Tanujaya Benidiktus
Published: June 2023

Penelitian ini bertujuan untuk mengetahui perbedaan hasil belajar materi perbandingan trigonometri peserta didik yang di ajar menggunakan model Problem Based-Learning dan peserta didik yang di ajar menggunakan model Direct Instruction. Desain penelitian ini adalah Randomized Subjects Posttest Only Control Design. Penelitian ini dilaksanakan di SMA Negeri 1 Tamako pada semester genap tahun ajaran 2022/2023. Subjek dalam penelitian ini di ambil 2 kelas yaitu kelas X 2 sebagai kelas eksperimen dan kelas X 3 sebagai kelas kontrol. Pengumpulan data dilakukan dengan memberikan tes berupa soal pada kedua kelas setelah diberi perlakuan. Data hasil penelitian dianalisis menggunakan statistik uji-t dan hasil perhitungan menunjukkan bahwa nilai     . Karena nilai  maka tolak . Dengan demikian dapat disimpulkan bahwa hasil belajar materi perbandingan trigonometri peserta didik kelas eksperimen lebih tinggi dari hasil belajar peserta didik kelas kontrol. Kata kunci: perbandingan trigonometri, model Problem Based-Learning, model Direct Instruction.