bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Sektor Ekonomi Unggulan di Kabupaten Batanghari
Authors: Yurliana Yurliana , R M.Rachmad , Rachmadi Selamet
Published: May 2022

Abstract. This study aimed to analyze the leading sectors in the district of Batanghari. The analysis tool used is location quotient, dynamic location quotient, shift-share and specialisation index. Based on the analysis found that the sectors of the economy in the district of Batanghari can be grouped into four criteria: 1) The leading sector is the services sector; 2) The main supporting sectors are the electricity sector and the transportation sector; 3) The prospective sectors are agriculture, industry, building and construction and trade sectors; 4) The less promising sector are the mining sector and the financial sector. Keywords: Leading sector, Main supporting sector, prospectif sector Abstrak Penelitian ini bertujuan untuk menganalisis sektor ekonomi unggulan di Kabupaten Batanghari. Alat analisis yang digunakan adalah location quotient, dinamic location quotient, shift-share dan indeks spesialisasi. Berdasarkan hasil analisis ditemukan bahwa sektor perekonomian di Kabupaten Batanghari dapat dikelompokkan atas empat kriteria yaitu: 1) sektor unggulan adalah sektor jasa-jasa; 2) sektor andalan adalah sektor listrik dan sektor pengangkutan; 3) sektor prospektif adalah sektor pertanian, industri, bangunan dan konstruksi serta sektor perdagangan; 4) sektor kurang prospektif adalah sektor pertambangan dan sektor keuangan. Kata kunci: Sektor unggulan, sektor andalan, sektor prospektif
Pengaruh Kompetensi Sumberdaya Manusia, Perangkat Pendukung dan Peran Auditor Internal terhadap Kualitas Laporan Keuangan Pemerintah Daerah Kabupaten Kerinci
Authors: Lasmara Freddie , Rahayu Sri
Published: May 2022

Abstract. This study aimed to analyze the effect of the competence of human resources, support tools and the role of the internal auditor of the quality of local government financial statements Kerinci. The method used is quantitative, criteria respondents in this study those concerned and involved technically in financial management, evaluating financial, and preparation of financial reporting in local government agencies Kerinci of 27 SKPD each SKPD researchers took four respondents consist of Subsection Head of Finance, Kasubbag Program, Evaluation and Reporting, Spending Treasurer and Treasurer Storage of Goods. Data processed by using multiple regression analysis. The results of this study demonstrate that the competence of human resources, support tools and the role of internal auditors jointly positive effect on the quality of financial reports of local government Kerinci district, the dominant factor is the competence of human resources this caused that for the preparation of financial statements required human resources who understand the financial management procedures. Keywords: Human Resources, Financial Management, Role of Internal Auditor   Abstrak. Penelitian ini bertujuan untuk menganalisis pengaruh kompetensi sumber daya manusia, perangkat pendukung dan peran auditor internal terhadap kualitas laporan keuangan pemerintah daerah Kabupaten Kerinci. Metode penelitian yang digunakan adalah penelitian kuantitatif, Kriteria responden dalam penelitian ini mereka yang berkaitan dan terlibat langsung secara teknis dengan pengelolaan keuangan, pengevaluasian keuangan, dan penyusunan pelaporan keuangan di instansi pemerintah daerah Kabupaten Kerinci dari 27 SKPD masing-masing SKPD peneliti mengambil 4 orang responden terdiri dari Kasubbag Keuangan, Kasubbag Program, Evaluasi dan Pelaporan, Bendahara Pengeluaran, dan Bendahara Penyimpan Barang. Data diolah dengan menggunakan analisis regresi berganda. Hasil penelitian ini membuktikan bahwa kompetensi sumber daya manusia, perangkat pendukung dan peran auditor internal secara bersama-sama berpengaruh positif terhadap terhadap kualitas laporan keuangan pemerintah daerah Kabupaten Kerinci, faktor yang paling dominan yaitu kompetensi sumber daya manusia hal ini di sebabkan bahwa untuk penyusunan laporan keuangan dibutuhkan sumber daya manusia yang mengerti tata cara pengelolaan keuangan. Kata Kunci : Sumberdaya Manusia, Manajemen Keuangan, Peran Auditor Internal
Analisis Kinerja Keuangan Pemerintah Provinsi Jambi dan Pengaruhnya terhadap Pertumbuhan Ekonomi
Authors: Mondes Mohar
Published: May 2022

The purpose of this research is to analise government’s financial performance of Jambi Province. This research is using multiple linear regression to calculate and to see the effect of direct and indirect expenditure variable to the economic growth. This research is using secondary data that includes of local revenues, equalization funds, financial reception area, direct and indirect expenditure and also total expenditure of Jambi Province. This research is using verifikatif and kuantitatif analysis which is suite for analise fiscal autonomy degree, fiscal dependency of Jambi Province toward central government and also to find out whether the direct and indirect expenditure has effect to economic growth. Research results showed that Jambi Province’s DOF based on local revenue is 39,57%, placed in average condition, however if local revenue is add on DBH, it showed that the criteria is very good with 58,92%. The level of fiscal dependency 34,80% in average for years during observasion periode. By using multiple linear regression, the result showed that direct and indirect expenditure were positively and significantly effected to the economic growth of Jambi Province
Determinan Belanja Pegawai Pada Pemerintah Kabupaten/Kota di Provinsi Jambi
Authors: Mutmaina Yowana Rachma
Published: May 2022

This study aimed to analyze: 1) The allocation of personnel expenditures in the district/city in Jambi Province. 2) Factors affecting personnel expenditure in the Regency / City in Jambi Province. The data used is secondary data based on panel data. The analysis tool used is panel data regression analysis. The results of the study found that: 1) During the period 2010-2014, the development of personnel spending in districts / city in Jambi Province showed an increasing trend; 2) The number of employees has a significant negative and significant impact on the expenditure of district / municipality employees in Jambi Province, while the number of Local Government’s Agencies (SKPD) has a positive and significant impact. Key Word : Personnel Expenditure, employees dan Local Governments’ Agencies Abstrak.Penelitian ini bertujuan untuk menganalisis: 1) Alokasi belanja pegawai kabupaten/kota di Provinsi Jambi. 2) Faktor-faktor yang mempengaruhi belanja pegawai pada Kabupaten/Kota di Provinsi Jambi. Data yang digunakan adalah data sekunder berdasarkan data panel. Alat analisis yang digunakan adalah analisis regresi data panel. Hasil penelitian menemukan bahwa: 1) Selama periode 2010-2014, perkembangan belanja pegawai pada kabupaten/kota di Provinsi Jambi menunjukkan kecenderungan yang terus meningkat; 2) Jumlah pegawai berpengaruh negatif dan signifikan terhadap belanja pegawai Kabupaten/Kota di Provinsi Jambi, sedangkan jumlah SKPD berpengaruh positif dan signifikan. Kata Kunci : Belanja Pegawai, Pegawai, Satuan Kerja Perangkat Daerah
Respuestas bioquímicas y fisiológicas del árbol Pterogine nitens (Fabaceae) a la deriva simulada de glifosato
Authors: Meloni Diego Ariel , Nieva María José , Aspiazú Ignacio
Published: May 2022

Introducción: En las últimas décadas, el área de  dispersión natural de P. nitens, estuvo sometida a un cambio en el uso de la tierra. Se expandió la frontera agropecuaria, a expensas del bosque nativo, con la incorporación de sistemas productivos que utilizan altas dosis del herbicida glifosato. Se desconoce el el grado de tolerancia de la especie al herbicida, y su respuestas fisiológicas. Objetivo: Evaluar las respuestas bioquímicas y fisiológicas de Pterogine nitens a la deriva simulada de glifosato. Métodos: Hicimos ensayos en invernáculo, con plantas de un año de edad, en macetas. Simulamos la deriva de glifosato, en dosis de 0,65 y 130g e.a. ha-1. Veinte días después de la aplicación, medimos las concentraciones de shikimato, pigmentos fotosíntéticos, y la composición mineral. Resultados: El glifosato incrementó las concentraciones de shikimato, y disminuyó las concentración de pigmentos fotosintéticos. También redujo las cocentraciones de potasio, magnesio, calcio, zinc, manganeso y hierro. Conclusiones: El glifosato altera la etapa fotoquímica de la fotosíntesis, al diminuir la concentración de pigmentos fotosintéticos. También interfiere con la homeostasis de macro y micronutrientes.
Decision information for auditors to assess litigation risk: Application of machine learning techniques
Authors: Lu Yu-Hsin , Lin Yu-Cheng , Gu Fang-Ci
Published: May 2022

Fraud cases have become more common in recent years, highlighting the role of auditors’ legal liability. The competent authorities have called for stricter control and disciplinary measures for auditors, increasing auditors’ legal liability and litigation risk. This study used machine learning (ML) techniques to construct a litigation warning model for auditors to assess audit risk when they evaluate whether accept or terminate an engagement, thus improving audit quality and preventing losses due to litigation. Otherwise, a sample matching method comprised of 64 litigated companies and 128 non-litigated companies was used in this study. First, feature selection technology was used to extract six important influencing factors among the many variables affecting auditors’ litigation risk. Then a decision tree was used to establish a litigation warning model and a decision table for auditors’ reference. The results indicated that the eight outcomes provided by the decision table could effectively distinguish the level of a litigation risk with an accuracy rate of 92.708%. These results can provide useful information to aid auditors in assessing engagement decisions.
Léxico juvenil en la Educación Media: Implicaciones filosóficas, usos y concepciones
Authors: Giraldo Henao Leandro Arbey
Published: May 2022

Léxico Juvenil en la Educación Media: Implicaciones Filosóficas, usos y concepciones, título que sirve a la presente obra, no constituye una sintaxis simple de unidades léxicas conjuntadas por consonancia semántica o capricho disciplinar. Este tema, en profundidad, obedece al deseo de comprensión sobre tres mundos hacia los que viajar ha precisado una tarea mayúscula de intertextualidad, conexiones y reivindicación. Sobre todo, para entender cómo la historia de la paideia griega ha cruzado siglos de asentada influencia en Occidente. De ahí que se aborden visiones teóricas fundamentales sobre el léxico juvenil, la pedagogía alternativa y las implicaciones filosóficas, cuyos cruces demandan esfuerzos comprometidos con el estudio de la pragmática lingüística, la pedagogía crítico-radical y la historia de la filosofía. Los textos que aquí se discuten, entonces, tienen la soltura tanto del propio desarrollo disciplinar, como de la trayectoria histórica que les cobija. De suerte que los esfuerzos presentados en el análisis y la comprensión del uso léxico-mediático y las concepciones de mundo del estudiante de educación Media contemporáneo, develan las conexiones con las que se contempla el fenómeno; al tiempo, que la fusión de los ojos del hombre moderno con la mirada del hombre griego y su paideia.
Asymptotical outer synchronization control for the complex dynamical networks with unknown bounded interaction via links dynamics
Authors: Chen Qingfeng , Wang Yinhe , Tang Xiao , Li Shengping
Published: May 2022

The nodes and their connection relationships (CRs) are the two main
parts for a complex dynamical network (CDN). In existing theoretical
studies about the outer synchronization, the nodes are considered as the
main part of synchronization phenomena mainly associated by coupling
effect of CRs between nodes. However, if the CRs between nodes are
time-varying, they can also be regarded as one dynamic system coupled
with the nodes, and thus their state may evolve with time and maybe
assist the nodes to achieve the outer synchronization. From the angle of
large-scale systems, a CDN can be regarded as two interconnected
subsystems, one of which is the node subsystem (NS) and the other is the
link subsystem (LS). Hence, how the whole dynamic of LS contributes to
the outer synchronization of NS is one of worthy research problem. In
this paper, the two CDNs are considered with the unknown interaction. In
each CDN, the dynamics of NS is modelled as the vector differential
equation, the LS is modelled as the Riccati matrix differential
equation, and the two kinds of differential equations are coupled with
each other. By employing the above dynamic models of CDNs and the
synthesized coupling terms in the two LSs, the adaptive controller of NS
is synthesized for the response CDN. The results show that the outer
synchronization happens when the two LSs tracking the synthesized
auxiliary dynamic tracking targets. Finally, the numerical simulation is
given to show the effectiveness of the theoretical results in this
paper.
An operative approach to solve Homogeneous differential--anti-differential equations
Authors: Hussain Sultan , Awan Abdul
Published: May 2022

In this work, we extend the theory of differential equations through a
new way. To do this, we give an idea of differential–anti-differential
equations and dene ordinary as well as partial
derivative{anti-derivative operator with a base function to solve
several types of such equations. The operator is applied to construct
several Auxiliary equations for a Homogeneous
differential–anti-differential equations. The roots, of the Auxiliary
equations, are then inserted in the base function to get exact solutions
of the corresponding equations. The process can be used to solve both
Homogeneous linear and non-linear ordinary as well as partial
differential–anti- differential equations. The technique has special
property that it can solve several different types of differential
equations including continuity, Heat, Wave, Laplace, Schrodinger, Euler,
Blasius differential equations.
Linking evapotranspiration seasonal cycles to the water balance of headwater catchments with contrasting land uses
Authors: Neto Alberto M. L. Peixoto , Cartwright Ian , Silva Marcela R. F. , McHugh Ian , Dresel P. Evan , Teodosio Bertrand , Jovanovic Dusan , McCaskill Malcom R. , Webb John , Daly Edoardo
Published: May 2022

Land use affects evapotranspiration rates and is a primary driver of the
catchment water balance. The water balance of two catchments in
southeastern Australia dominated by either grazed pasture or blue gum (
Eucalyptus globulus) plantation was studied, focusing on the
patterns of evapotranspiration (ET) throughout the year. Rainfall,
streamflow, and groundwater levels measured between 2015-2019 were
combined to estimate annual ET using a water balance equation. In the
pasture, eddy covariance was used to measure ET from the catchment. Sap
flow measurements were used to estimate tree transpiration in May 2017
– May 2018 and Feb 2019 – Feb 2021 in two different plots within the
plantation. The tree transpiration rates were added to direct
evaporation, estimated as a percentage of annual rainfall, to calculate
ET from the plantation catchment. ET in the pasture showed strong
seasonal cycles with very low ET rates in summer and ET rates in spring
that were larger than the transpiration rates in the plantation, where
trees transpired consistently throughout the year. The estimated annual
ET from the water balance equation were comparable to ET estimated from
other measurements. In the pasture, ET on average accounted for 88% of
annual rainfall, while ET in the plantation was on average 93% of
rainfall, exceeding it in the years with annual rainfall lower than 500
mm. The difference between the ET rates in the plantation and the
pasture were approximately 30 to 50 mm y­ . The
larger ET rates in the plantation are reflected in a gradual decrease in
the groundwater storage. The differences in ET rates were thus enough to
cause a decrease in groundwater storage in the plantation, while the
groundwater levels in the pasture remained stable.
Allee Effects and Coexistence
Authors: Walker Emma , Gilbert Benjamin
Published: May 2022

Allee effects are common to diverse taxa but their consequences for
coexistence are poorly understood. Recent studies suggest they cause
priority effects through ‘inverse’, or positive, density dependence when
a population is at low density, but mathematical theory suggests more
outcomes are possible. We develop a simple and generalizable competition
model that incorporates an Allee effect, with the Allee effect
characterized by its low-density strength and dissipation rate. By
incorporating Allee effects into modern coexistence theory, we show how
Allee effects alter both fitness differences and stabilizing
differences. We then determine when Allee effects promote or limit
diversity, and when modern coexistence theory fails to predict
coexistence outcomes. Our model offers an intuitive extension of modern
coexistence theory while identifying one of its limits for predicting
diversity, and promises to guide empirical research on how Allee effects
structure ecological diversity.
Metastatic squamous carcinoma of cervix with tricuspid valve involvement
Authors: Lei Yong
Published: May 2022

Background: Cervical squamous cell carcinoma is one of the most
common malignant tumors in the clinic. It can metastasize to the lung,
bone, and other organs. However, postoperative recurrence and metastasis
to the tricuspid valve are infrequent.  Case
presentation: A 57-year-old female patient, which had an operation
history of squamous carcinoma of the cervix(SCC) one year ago, was
admitted to the hospital due to the cervical squamous cell carcinoma
recurred and metastasized to the tricuspid anterior and septum’
ventricular surface and the chordae tendineae. The patient underwent
surgery in our hospital.Then the positron emission tomography-computed
tomography of postoperation revealed cervical squamous cell carcinoma
metastasis. Histopathology revealed the squamous carcinoma of the
cervix.Moreover, the cardiac tumor reappeared after four postoperation
months. The postoperative patients did not receive regular chemotherapy.
The short-term effect on the patients was not ideal. 
Conclusion: To achieve better treatment results, the multi-mode
treatment strategy of surgery, medical treatment, and advanced diagnosis
has a significant impact on the survival of these patients.
Predictive Metabolomic Markers in Early to Mid-Pregnancy for Gestational Diabetes: A Prospective Test and Validation Study
Authors: Zhu Yeyi , Barupal Dinesh K , Ngo Amanda L , Quesenberry Charles P , Feng Juanran , Fiehn Oliver , Ferrara Assiamira
Published: May 2022

 Gestational diabetes (GDM) predisposes pregnant individuals to perinatal complications and long-term diabetes and cardiovascular diseases. We developed and validated metabolomic markers for GDM in a prospective test-validation study. In a case-control sample within the PETALS cohort (91 GDM, 180 non-GDM; discovery set), a random PETALS subsample (42 GDM, 372 non-GDM; validation set 1), and a case-control sample within the GLOW trial (35 GDM, 70 non-GDM; validation set 2), fasting serum untargeted metabolomics were measured by gas chromatography/time-of-flight mass spectrometry. Multivariate enrichment analysis examined metabolites-GDM associations. Ten-fold cross-validated LASSO regression identified predictive metabolomic markers at gestational weeks (GW) 10-13 and 16-19 for GDM. The purinone metabolites at GW 10-13 and 16-19, and the amino acids, amino alcohols, hexoses, indoles, and pyrimidines metabolites at GW 16-19 were positively associated with GDM risk (FDR <0.05). A 17-metabolite panel at GW 10-13 outperformed the model using conventional risk factors including fasting glycemia (discovery AUC: 0.871 vs. 0.742; validation 1: 0.869 vs. 0.731; validation 2: 0.972 vs. 0.742; P <0.01). Similar results were observed for a 13-metabolite panel at GW 17-19. Dysmetabolism is present early in pregnancy among individuals progressing to GDM. Multi-metabolite panels in early pregnancy can predict GDM risk beyond conventional risk factors.  
Mucocutaneous Adverse Reactions to COVID-19 Vaccines: Do Excipients Play a Role?
Authors: Bianchi Leonardo , Biondi Filippo , Hansel Katharina , Murgia Nicola , D'Arpino Alessandro , Tramontana Marta , Stingeni Luca
Published: May 2022

Abstract is missing (Short communication)
Symmetrical White Transparent Papules: A Quiz
Authors: Lin Zhen-Ting , Jiang-Wei Cheng  , Hao Guo  , Jiu-Hong Li
Published: May 2022

Abstract is missng (Quiz)
Improvement of Vitamin D 3 Metabolites Level after Oral Administration of the Biofield Energy Treated Proprietary Test Formulation in Vitamin D 3 Deficiency Diet (VDD) Induced Rat Model
Authors: S Jana
Published: May 2022

The present experiment was evaluated to study of the effect of Consciousness Energy Healing Treatment (the Trivedi Effect ® ) on novel proprietary test formulation in male Sprague Dawley (SD) rats, fed with vitamin D3 deficiency diet (VDD) for the estimation of vitamin D3 metabolites in kidney tissue. A novel proprietary test formulation was formulated with a few minerals (magnesium, zinc, copper, calcium, selenium, and iron), vitamins (ascorbic acid, pyridoxine HCl, alpha tocopherol, cyanocobalamin, and cholecalciferol), Panax ginseng extract, β-carotene, and cannabidiol isolate. The novel test formulation was divided into two parts; one part was defined as the untreated test formulation, while the other part of the test formulation and the animals received Biofield Energy Healing Treatment by a renowned Biofield Energy Healer, Mr. Mahendra Kumar Trivedi. 25-OH vitamin D 3 level was significantly increased in the Biofield Energy Treated test formulation group (G5), Biofield Energy Treatment per se (G6), and 15-days pre-treatment of the Biofield Energy Treated test formulation (G7) groups by 21%, 22.9%, and 11.5%, respectively as compared with the disease control group (G2). Additionally, the level of 1,25-(OH) 2 D 3 was increased by 55% in the G6 group as compared with the G2. Further, the expression of CYP24A in kidney was increased by 13.9% in the G6 group, while CYP27B expression in kidney was significantly increased by 17.6%, 18.6%, 10.1%, and 15.6% in the G5, G6, G7 (Biofield Energy Treated test formulation from day -15), and G8 (Biofield Energy Treatment per se plus Biofield Energy Treated test formulation from day -15) groups, respectively as compared with the G4 group. Vitamin D receptor (VDR) expression was significantly increased by 69.5% and 31% in the G6 and G7 groups, respectively as compared with the G2 group. Overall, the results showed significant improvement of the availability of vitamin D 3 metabolites, that could be helpful for the vitamin D 3 deficiency persons to maintain good bone health and immunity. Therefore, the results suggest that there was significant slowdown in the disease progression and disease related all other complications/symptoms in the Biofield Energy Treatment group per se and/or Biofield Energy Treated Test formulation groups ( viz . G6, G7, G8, and G9) comparatively with the disease group.
Assessment of Oral Bioavailability of Vitamin D 3 and Its Metabolite, 25-hydroxy (OH) Vitamin D 3 in Male Sprague Dawley Rats Following a Single Oral Dose of Biofield Energy Treated Vitamin D 3
Authors: S Jana
Published: May 2022

The present study was performed to determine the effects of The Trivedi Effect ® -Energy of Consciousness Healing Treatment on vitamin D 3 and rats through the pharmacokinetic parameters measurement of both plasma level of vitamin D 3 and 25-hydroxy (OH)-vitamin D 3 after the oral administration of vitamin D 3 in rats. The test item, vitamin D 3 was divided into two parts. One part was denoted as the control (without Biofield Energy Healing Treatment), while the other part was defined as the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment by renowned Biofield Energy Healer, Mahendra Kumar Trivedi. Additionally, one group of animals also received Consciousness Energy Healing Treatment per se by the Healer under similar conditions. Vitamin D 3 oral formulations were administrated by oral gavage at a dose of 500 μg per kg in groups viz. G1 (untreated Vitamin D 3 ), G2 (Biofield Energy Treated Vitamin D 3 ) and G3 (Biofield Energy Treated animals received untreated Vitamin D 3 ) group. The results showed that the relative oral exposure (AUC 0 –t) of vitamin D 3 was significantly increased by 155.62% and 111.73% in G2 and G3 groups, respectively as compared to the control group. Biofield Energy Treatment also significantly improved the plasma peak concentration (C max ) of vitamin D 3 by 223.84% and 187.5% in G2 and G3 groups, respectively as compared to the control group. This study results also showed that the relative oral exposure (AUC 0 –t) of 25-hydroxy (OH)-vitamin D 3 (metabolite) was significantly increased by 161.28% and 113.96% in G2 and G3 groups, respectively as compared to the control group (G1). Biofield Energy Treatment also significantly improved the plasma peak concentration (C max ) of 25-hydroxy (OH)-vitamin D 3 by 174.25% and 111.77% in G2 and G3 groups, respectively as compared to the control group. After oral administration, plasma concentrations of active metabolite, 25-hydroxy (OH)-vitamin D 3 in all three groups were declined slowly. The mean residence time (MRT last ) and elimination rate constant (K el ) for this metabolite were unaltered in all three groups. These data suggest that Biofield Energy Treated vitamin D 3 might be influenced in vivo biological activity of vitamin D 3 due to increased plasma exposure (AUC) of both vitamin D 3 and metabolite level, 25-hydroxy (OH)-vitamin D 3 in rats. There was significant improvement (>100%) of relative oral bioavailability of both vitamin D 3 and 25-hydroxy (OH)-vitamin D 3 that might be due to the alteration of physicochemical properties and thermal properties of vitamin D 3 by the Biofield Energy Treatment. Biofield Energy Healing Treatment could be an innovative strategy that opens new avenues to overcome poorly absorbed pharmaceuticals/nutraceuticals/herbal extracts and can also improve the therapeutic performance of orally active molecules.
Bioequivalence and Pharmacokinetics of Carvedilol (6.25 and 12.5 Mg Tablets) in Healthy Thai Volunteers
Authors: V Khaowroongrueng
Published: May 2022

The Government Pharmaceutical Organization (GPO) had developed the generic products of carvedilol 12.5 and 6.25 mg tablets as low-cost alternatives for patients and physicians to enhance patient adherence and accessibility to long-term use medications. Two bioequivalence studies were conducted to evaluate the bioequivalence between the test and reference products of carvedilol 12.5 mg and 6.25 tablets. The design for both studies was comparative randomized, open-label, single- dose, two-way crossover. Carvedilol and 4′-hydroxyphenyl carvedilol (active metabolite) concentrations in plasma were simultaneously determined by a validated liquid chromatography tandem mass spectrometry method. The pharmacokinetic analysis was carried out for carvedilol and 4′-hydroxyphenyl carvedilol. The pharmacokinetic parameters describing the rate and extent of absorption of carvedilol (AUC 0-tlast , AUC 0-∞ and C max ) were used to conclude the bioequivalence between the test and reference products whereas the pharmacokinetic parameters of 4′-hydroxyphenyl carvedilol were presented as supportive information. The statistical analysis was calculated using an analysis of variance and did not show any significant difference between the two formulations. The 90% confidence intervals of the geometric least squares mean ratios (test/ reference) of ln-transformed AUC 0-tlast , AUC 0-∞ and C max were 98.54-106.94%, 98.54-106.56% and 90.70-104.84%, respectively for carvedilol 12.5 mg tablets, and 95.56-105.99%, 94.80-104.98% and 92.00-107.33%, respectively for carvedilol 6.25 mg tablets. The results were well within 80.00-125.00% corresponding to the bioequivalence criteria. Therefore, the generic carvedilol products (Carvolol) at both strengths are bioequivalent with the innovator products (Dilatrend) in terms of rate and extent of absorption. Similar findings were observed for 4′-hydroxyphenyl carvedilol, thus therapeutic equivalence between the test and reference formulations could also be anticipated. The products were well tolerated by the study subjects and no serious adverse events were reported in both studies.
Bioequivalence of a Preparation of Tulathromycin in Cattle
Authors: LH Sumano
Published: May 2022

Testing the quality of antibacterial pharmaceutical preparations that can be regarded as generic is of utmost importance to ensure sustainable medical practices. Hence, comparative pharmacokinetics studies become necessary. In this trial, a new pharmaceutical preparation of tulathromycin (TTM) was submitted to a bioequivalence test, taking the reference preparation of this macrolide derivative as control i.e., the commercial preparation of TTM containing 100 mg of the drug Pisadrax ® , manufactured by PiSA Agropacuaria S.A. de C.V. and the reference brand of TTM Draxxin ® (Zoetis, Mexico). Twenty-four young steers Charolais/Brahman randomly divided into two groups of twelve animals each, received a single injection of 2.5 mg/kg subcutaneously of either preparation. A validated HPLC-masses analytical technique of plasma concentrations of tulathromycin was used to determine TTM plasma concentrations at fixed intervals for 240 h. The key pharmacokinetic parameters were obtained by compartmental and non-compartmental analysis. Results show that the experimental preparation of tulathromycin (Pisadrax ® ) can be regarded as bioequivalent to the reference one (Draxxin ® ) in steers, given that AUC0-240, MRT, and K½el values from both preparations resulted statistically indistinguishable and with confidence interval > 95%.
Research, Mapping and Subsequent Control of Waste in Water Bodies
Authors: TD Nikolay
Published: May 2022

In recent decades, there has been a sharp increase in waste that pollutes the environment. The largest share in them is nondegradable plastic waste. Most of them are located in the water bodies of the continents or in the ocean. Mankind faces the challenge of saving the world or destroying it. Only this year in Bulgaria along the rivers Iskar, Mesta, Danube, Yantra and others was observed accumulation of huge amounts of household and plastic waste. It was even necessary to organize the raking and transportation of these floating masses to the legal landfills. These events prompted the representatives of the Curious Club to propose the creation of a prototype, which on its own floating on water bodies to capture the state of the environment, the presence of unregulated landfills and waste, as well as the discharge of wastewater from illegal sewers. This device will collect and transmit information that club members will map and systematize. We are also proposing the introduction of a method imposed last year in Australia for the use of wastewater netting. We will also use our knowledge after the equipment of the astronomical club both for monitoring space debris and for the growing areas of floating islands of plastic waste in the world's oceans. Technologies that are innovative and have a future to solve these global problems are used. These things can be solved with our enthusiasm and financial support of economic entities interested in the cleanliness of the environment.
Analysis of Selected Physico-Chemical Parameters, Nutrients, and Heavy Metals in Drinking Water Samples in Halaba Town, SNNPR, Ethiopia
Authors: ZH Melaku
Published: May 2022

Residents in the Halaba town, SNNPR, Ethiopia have used tap water as the main source of water for their drinking and domestic purposes. However, the Physico-chemical parameters of tap water in Halaba town have not been studied and this study was aimed to investigate some Physico-chemical parameters and selected heavy metals in tap water samples collected from two sampling sites in Halaba town. All the samples were analyzed for selected heavy metals such as Zn, Cu, Pb Ni, Cr, Fe, Mn, and some Physico-chemical parameters such as EC, pH, TDS, TH, turbidity, K, Ca, Mg, nitrate, and sulfate using Flame Atomic Absorption Spectrometer (FAAS) and Paline test methods, respectively. The mean results of the physicochemical parameters investigated in tap water samples collected from two sampling sites were found to be in the range: EC (193.3–323.3) 𝜇S/cm, pH (7.88–7.9), TDS (96.7–175) mg/L, TH (24-30) mg/L, turbidity (3.93–4.53) NTUs, NO3-1(1.64–1.75) mg/L, SO4-2(1.3–3.3) mg/L. The mean concentrations of heavy metals were found to be in the range: Zn (0.05–0.30) mg/L, Fe (0.25–0.50) mg/L, Cu (0.01–0.04) mg/L, Pb (0.01–0.02) mg/L, Ni (1.86–2.4) mg/L, Cr (0.08–0.14) mg/L, Mn (0.001) mg/L, K (44.3–88.7) mg/L, Ca (180–204) mg/L, Mg (6.3–13) mg/L. The study showed that the concentrations of Pb, Ni, and Cr were slightly higher than the maximum permissible limits recommended by WHO, USEPA, and EU standards whereas concentrations of K and Ca were found to be higher than the maximum permissible limits recommended by WHO. All the other selected physicochemical parameters considered were below the maximum permissible limits recommended by WHO. Furthermore, the concentration of Zn, Cu, Fe, and Mn were found to be below the maximum permissible limits recommended by WHO, USEPA, EU, Australian, Iranian, Indian, Malaysian, Newzlandian, and Ethiopian standards. Therefore, citizens in the Halaba town that uses tap water for their day-to-day domestic activities and drinking purpose could potentially expose to health risks due to high levels of Pb, Ni, Cr, K and Ca. So, it is recommended that the tap water in the study area should be treated before being used for drinking and domestic purposes.
Pendampingan Good Manufacturing Practice Pada IKM Kerupuk Kemplang Ummy Nissa, Gedung Tataan–Kabupaten Pesawaran
Authors: Yuliana Neti , Sartika Dewi , Setiawan Teguh
Published: May 2022

Ummy Nissa, merupakan salah satu IKM yang memproduksi kerupuk kemplang yang terletak di Gedung Tataan, Kabupaten Pesawaran. Pelaku usaha Ummy Nissa belum mengenal dan memahami bagaimana cara berproduksi pangan yang baik, sehingga memerlukan pendampingan dalam penerapan Good Manufacturing Practice (GMP). Kegiatan pendampingan dilakukan dengan tahapan: (1) evaluasi pelaksanaan GMP pada IKM Ummy Nissa, (2) pelatihan GMP melalui ceramah dan diskusi, dan (3) praktik berproduksi sesuai dengan GMP. Prinsip prinsip GMP mengacu pada surat keputusan menteri RI No: 23/Men.Kes/SK/I/1978 tentang pedoman cara berproduksi makanan yang baik. Pendampingan meningkatkan skor penilaian dari kriteria kurang menjadi cukup, dan kriteria cukup menjadi baik pada butir-butir terpilih dari 13 aspek penilaian penerapan GMP.
Pelatihan Pembuatan Hand Sanitizer Sebagai Edukasi Pencegahan Dini Covid-19 Di SD Swasta Bani Adam AS
Authors: Dalimunthe Makharany , Amdayani Susilawati , Sihombing Junifa Layla , Sugiharti Gulmah , Herlinawati Herlinawati , Kambaren Agus , Simatupang Lisnawati
Published: May 2022

Kegiatan PKM dilatarbelakangi dengan adanya keputusan pemerintah terkait pelaksanaan pembelajaran di zona kuning dan hijau, untuk dapat melaksanakan pembelajaran tatap muka dengan penerapan protokol kesehatan yang sangat ketat. SD Swasta Bani Adam AS adalah salah satu sekolah yang ikut melaksanakan pembelajaran tatap muka. Salah satu persyaratan yang harus dipenuhi supaya sekolah dapat melakukan pembelajaran tatap muka adalah ketersediaan sarana sanitasi dan kebersihan, seperti toilet bersih dan layak, adanya sarana cuci tangan pakai sabun atau hand sanitizer dan desinfektan. Oleh karena itu, kebutuhan hand sanitizer diperlukan sebagai alternatif untuk mencuci tangan di lingkungan sekolah. Metode pelaksanaan PKM ini adalah menjalin kerjasama Tim Pelaksana dan LPPM UNIMED, penyuluhan dan pelatihan kepada kelompok mitra. Dalam kegiatan ini Tim pelaksana telah mensosialisasikan tentang program Pengabdian, tujuan kegiatan, target dan luaran yang akan dicapai, dan untuk meningkatkan pengetahuan masyarakat mitra telah dijelaskan tentang pemanfaatan lidah buaya sebagai bahan alami dalam pembuatan hand sanitizer.
Analisi Strategic Location dan Marketing Communication Terhadap Minat Beli di Perumahan Azalea Garden Tanggerang
Authors: Abdullah Muhamad Al Faruq , Fathihani Fathihani
Published: May 2022

This study aims to determine the effect of strategic location and marketing communication on the purchasing decisions of respondents who are housing owners in Azalea Garden. This research is descriptive. Primary data and secondary data were obtained. Secondary data was obtained from various sources such as journals, books and other related primary publication data obtained by distributing questionnaires to target respondents. By using convenience sampling technique, the target sample is at least 100 respondents. The analytical method used in this research is Variance Based Structural Equation Modeling - Partial Least Square and data processing using SmartPLS version 3.0 program. This study shows the results that strategic location and marketing communication have a positive relationship and have a significant effect on purchase intention. The variability of strategic location and marketing communication constructs is 70.1% on purchase intention.
Analisis Kebijakan Pemerintah Provinsi DKI Jakarta dalam Mengatasi Permasalahan Transportasi di Perkotaan
Authors: Mu’allimah Mu’allimah , Mashpufah Raina Nurvita
Published: May 2022

Transportation problems often arise in the midst of the rapid development of a region. The problem of transportation in urban areas that often occurs is traffic density caused by the volume of vehicles that are not balanced with road capacity. This imbalance can later lead to congestion points in urban areas. Various efforts have been made by the DKI Jakarta government in overcoming traffic jams. This study intends to analyze the effectiveness of policies that have been set by the government in overcoming transportation problems. The research method used is descriptive qualitative. This research comes from data sources in the form of scientific journals, book literature, official websites which are described through descriptive analysis, namely describing the implementation of odd-even policies, MRT project development policies, and development of Transjakarta
The Influence of Psychological Capital and Person Organization Fit on Teacher Performance with Organizational Commitment as Mediation
Authors: Santosa Agus Budi , Nusantara Agung , Nawatmi Sri , Sebastian Febri
Published: May 2022

The teacher is a key element in the education system, especially in schools because of the teacher's role in transforming knowledge in education. Therefore, schools can improve teacher performance in order to achieve predetermined educational goals. This article will analyze the influence of psychological capital and person organization fit on teacher performance by mediating organizational commitment. This research uses quantitative analysis. The population in this study were 108 teachers of Junior High School in Bantarbolang District. Analysis of data techniques used regression analysis. The results of the research on model 1 show that psychological capital and person organization fit have a positive effect on organizational. In model 2, psychological capital and organizational commitment have a positive effect on teacher performance while organizational people do not. The results of the mediation test show that organizational influence does not mediate the effect of psychological capital on teacher performance, but organizational commitment mediates.
Pengembangan supervisi Elektronik untuk Meningkatkan Kinerja Guru di SD Negeri 02 Percontohan Bukittinggi Sumatera Barat
Authors: Bukhari Masri
Published: May 2022

This research aims to develop electronic supervision which consists of elecctronic supervision hardware, step by step electronic supervision, working procedure electronic supervision, feed back and follow up electronic supervision, and to describe teacher performance after developing electronic supervision. This research uses qualitative descriptive approach. The design is action research. The informan are the teachers and school principal of SD Negeri 02 Percontohan Bukittinggi West Sumatera. The method of data collection: interviews, observations, and documentation. The technique to determine data validation: credibility, transferability, dependabilitu, and confirmability. The data analize: data redection, data display and data conclusion. The result proved that before development: electronic supervision hardware only can be used in principal room with one computer, supervisor don’t understand about step by step electronic supervision, supervisor have no working procedure of electronic supervision, feed back and follow up the electronic supervision haven’t done rapidly. Teacher performance is no so good in class room management, learning and teaching activity, and communicating with the student. After development: electronic supervision hardware developed rapidly, supervisor can supervisi the teacher in all over the school with some computer, laptop, and handphone also. Supervisor understood electronic supervision procedure, feed back and follow up of electronic supervision done by making agreement with the teacher. And teacher performance is good enough especially in class room management, learning and teaching activity and communicating with the student.
STUDENTS’ PERCEPTION ON THE FACILITATION STRATEGIES PROVIDED BY TEACHERS IN ASYNCHRONOUS ONLINE DISCUSSION
Authors: Dewi Gusti Putu Rustika , Santosa Made Hery
Published: May 2022

Facilitation strategies provided in asynchronous online discussion environment becomes essential aspects in learning. This present study was a case study aimed at exploring EFL students’ perception on facilitation strategies provided in asynchronous online discussion in terms of monitoring, feedback and scoring rubric implemented in the online discussion. Questionnaire was administered to one hundred students and interview was conducted to six voluntary students who were enrolled in courses with asynchronous online discussion. The result indicated that students’ perception on the facilitation strategies provided in asynchronous online discussion was neutral which indicated that facilitation provided by teachers did not become the main preference for the students in asynchronous online discussion. Students perceived teachers’ monitoring positively since the students need more guidances to understand the concept as well as to indicate that their participation is apprecited by the teachers. Meanwhile, students had neutral perception toward feedback and scoring rubric provided in asynchronous online discussion. They perceived that feedback and scoring rubric are not essential elements that influence their participation in asynchronous online discussion. Furthermore, it implied that the facilitation strategies provided in asynchronous online discussion has to enable teacher to check students progress and to motivate students to engage in asynchronous online discussion.
Türkiye’de okul öncesi eğitim ve kanıt temelli sınıf yönetimi stratejileri
Authors: Meran Sevil , Sucuoğlu Nimet Bülbin
Published: May 2022

Tüm öğrenciler için başarılı bir öğrenme çevresinin oluşturulması ve sürdürülmesi amacıyla öğretmenler tarafından planlanan ve uygulanan etkinlikler bütünü olan sınıf yönetimi (SY) her öğrencinin akademik ve sosyal yaşamdaki başarısına etki eden faktörlerin başında gelmektedir. 1990’lı yıllardan sonra kanıt temelli uygulamalar kavramının eğitim alanına girmesi ve hızla yaygınlaşması sonucunda SY konusundaki çalışmalarda gittikçe daha fazla ölçüde çocukların akademik becerileri ve davranışları üzerinde etkili olduğu deneysel araştırmalarla kanıtlanmış SY stratejilerinin önemi vurgulanmaya başlanmıştır. Bu çalışmada, okul öncesi (OÖ) öğretmenlerinin hangi SY stratejilerini kullandıklarının belirlenmesi amacıyla, 2005-2020 yılları arasında ülkemizde yayınlanan SY çalışmaları taranmış; kullanılan stratejiler kanıt temelli sınıf yönetimi (KTSY) çerçevesinde gözden geçirilmiştir. Ayrıca doğrudan kanıt temelli stratejiler arasında yer almayan fakat SY ile ilişkili olduğu kabul edilen bütünleştirme ve aile katılımı konuları da çalışma kapsamında ele alınmıştır. Çalışma sonunda, KTSY stratejilerinin OÖ eğitimde kullanılmasının önemi vurgulanarak, OÖ öğretmenleri için geliştirilen hizmet öncesi ve hizmet içi programlarda KTSY stratejilerine yer verilmesi önerilmiştir.
Okul Öncesi Matematik Öğretim Bilgisi Testi: Uyarlama ve uygulama çalışması
Authors: Akdeniz Koray , Şimşek Nurullah
Published: May 2022

Türkiye’de bugüne kadar farklı öğretmen yetiştirme politikaları uygulanmıştır. Bu bağlamda eğitim fakülteleri dışında farklı fakülte mezunlarına da öğretmen olma fırsatı verilmektedir. Bu çalışmanın amacı, sağlık bilimleri fakültesi, çocuk gelişimi bölümünde öğrenimine devam ederken veya mezun olarak eğitim fakültesinde pedagojik formasyon eğitimi sertifika programına kayıtlı okul öncesi öğretmen adayları ile eğitim fakültesi okul öncesi öğretmenliği programına kayıtlı öğretmen adaylarının matematik öğretim bilgilerini değerlendirmektir. Bu amaç doğrultusunda, Smith (1998) tarafından geliştirilen okul öncesi matematik öğretim bilgisi testinin Türkçeye uyarlama çalışmaları yapılmıştır. Bu doğrultuda, dilsel eşdeğerlik çalışması iki aşamada toplamda 64 katılımcı ile gerçekleştirilmiştir. Geçerlik ve güvenirlik çalışmalarına ise altı farklı üniversiteden 480 öğretmen adayı katılmıştır. Elde edilen veriler ışığında öğretmen adaylarının matematik öğretim bilgilerinin öğrenim gördükleri programa göre anlamlı bir şekilde değişmediği görülmüştür.
El tercer gran salto: los coronavirus animales en América Latina
Authors: Colina Santiago Emanuel , Aspitia Carolina Gabriela , Nogueiras Juan Pablo , Serena María Soledad , Echeverría María Gabriela , Metz Germán Ernesto
Published: May 2022

Una partícula viral de aproximadamente 120 nm ha modificado totalmente lo que sucede en nuestro mundo de 12.000 km de diámetro. La primera epidemia del coronavirus del síndrome respiratorio agudo grave (SARS), y luego la del síndrome respiratorio de Oriente Medio (MERS), alertaron del potencial de transmisión entre especies de esta familia viral. Sin embargo, no fue hasta su tercer gran salto con la pandemia del SARS-CoV-2 que el foco de toda la comunidad científica se centró en ellos. Existen diversos saltos interespecies reportados en medicina veterinaria que no son más que intentos de los coronavirus de perfeccionar su potencial de transmisión para llegar a más de 7 mil millones de huéspedes en quienes replicar. Este artículo describe las características morfológicas y genéticas de los coronavirus, su particular mecanismo de replicación y cómo este influye en su diseminación. Del mismo modo, se describen signos clínicos, lesiones, variantes antigénicas y control mediante vacunación de los principales coronavirus asociados a diferentes especies animales, con un especial énfasis en los antecedentes reportados sobre coronavirus en América Latina.
amor qu’es fino amor en la lírica medieval
Authors: Castro Rodríguez María Luisa
Published: May 2022

El artículo problematiza el uso del concepto ‘amor cortés’ para el análisis literario de la literatura medieval y propone revisar algunos de los rasgos que lo conforman —la feudalización del amor, la caracterización de la amada y el secreto— a través de un análisis diacrónico de la poesía cortesana de la Edad Media —la lírica occitana o provenzal, la lírica gallego-portuguesa y la lírica castellana. Se propone una evolución de estos rasgos que permite observar las constantes y variaciones del ‘amor cortés’ en las producciones poéticas cortesanas medievales.