bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Social Media in the Process of Informing the Public About Disaster Risks
Authors: Cvetković Vladimir M. , Nikolić Aleksandra
Published: January 2023

Social media informs the public about the most important events and conveys important information. Before, during and after disasters, social media are used to disseminate information about disasters and to collect data relevant to the implementation of preparedness, response and recovery activities and measures. Social networks are effective in disseminating information and warnings, as well as in educating the public. The subject of the research is examining the influence of demographic factors on the effectiveness of social media in informing the public about the risks of disasters. Using an online survey questionnaire, and according to the snowball principle, a survey of 247 respondents was conducted in 2022. The research results show no statistically significant relationship between the level of education of the respondents and the assessment of the effectiveness of social media reporting on disasters. The use of social media can improve communication between stakeholders in disaster management and facilitate coordination of efforts, fostering communication and allocation of resources. To effectively use social media in disaster management, decision-makers in the disaster management system must be aware of new technologies, their disadvantages and advantages, as well as ways in which data from social networks can be collected and analyzed.
Recent Advances of Modified Ni (Co, Fe)-based LDH 2D Materials for Water Splitting
Authors: Li Guang Chen , Bao Peng Yu , Liu Zhou En , Zhao Ran Bin , Sun Tao
Published: January 2023

Water splitting technology is an efficient approach to generate hydrogen (H2) energy, which can well address the problems of environmental deterioration and energy shortage, as well as establishment of a clean and sustainable hydrogen economy powered by renewable energy sources due to the green reaction of H2 with O2. While the efficiency of H2 production by water splitting technology is intimately related with the reactions on electrode. Nowadays, the efficient electrocatalysts in water splitting reactions are the precious metal-based materials, i.e., Pt/C, RuO2 and IrO2. Ni (Co, Fe)-based layered double hydroxides (LDH) 2D materials are the typical non-precious metal-based materials in water splitting with advantages of low cost, excellent electrocatalytic performance and simple preparation methods, which exhibits a great potential for the substitution for precious metal-based materials. This review summarizes the recent progress of Ni (Co, Fe)-based LDH 2D materials for water splitting, which mainly focuses on discussing and analyzing the different strategies to modify LDH materials towards high electrocatalytic performance. We also discuss the recent achievements including their electronic structure, electrocatalytic performance, catalytic center, preparation process and catalytic mechanism. Furthermore, the characterization progress in revealing electronic structure and catalytic mechanism of LDH is highlighted in this review. Finally, we put forward some future perspectives related to design and explore advanced LDH catalysts in water splitting.
Risk Factors for Mortality of Adult Patients With COVID-19: A Two-Year Cohort Study in a Private Tertiary Care Center in Mexico
Authors: López Pérez Carlos Axel , Santa Cruz Pavlovich Francisco Javier , Montiel Cortés Juan Eduardo , Nuñez Muratalla Adriana , Morán González Ruth Bibani , Villanueva Gaona Ricardo , Franco Mojica Xochitl , Moreno Sandoval Denisse Gabriela , González Bañuelos Joselyn Anacaren , López Pérez Alan Ulises , Flores González Marily , Grijalva Ruiz Cristina , Valdez Mendoza Edna Daniela , González Lucano Luis Renee , López Zendejas Martín
Published: January 2023

During the COVID-19 pandemic, the high prevalence of comorbidities in Mexico, as well as the disparities between public and private health subsystems, substantially contributed to the severe impact it had in the country. The objective of this study was to evaluate and compare risk factors present at admission for mortality of hospitalized patients with COVID-19. A 2-year retrospective cohort study of hospitalized adult patients with COVID-19 was conducted at a private tertiary care center. The study population consisted of 1,258 patients with a median age of 56 ± 16.5 years, of whom 1,093 recovered (86.8%) and 165 died (13.1%). In the univariate analysis, older age (p <0.001), comorbidities such as hypertension (p <0.001) and diabetes (p <0.001), signs and symptoms of respiratory distress, and markers of acute inflammatory response were significantly more frequent in non-survivors. The multivariate analysis showed that older age (p <0.001), the presence of cyanosis (p 0.005) and previous myocardial infarction (p 0.032) were independent predictors for mortality. In the studied cohort, risk factors present at admission associated with an increased risk of death were older age, cyanosis and a previous myocardial infarction, which can be used as valuable predictors for patients’ outcomes. To our knowledge, this is the first study analyzing predictors of mortality in COVID-19 patients attended on a private tertiary hospital in Mexico.
Responses in the Coupling of Carbon and Water Vapor Exchanges of Irrigated and Rainfed Andean Potato (Solanum Tuberosum Subsp. Andigenum) Agroecosystems
Authors: Martinez Maldonado Fabio Ernesto , Castaño Marín Angela Maria , Góez Vinasco Gerardo Antonio , Marin Fabio Ricardo
Published: January 2023

We studied the link between carbon and water fluxes to understand the response of net ecosystem carbon exchange (NEE) to water availability conditions of three different potato water regimes cropping systems [full irrigation (FI), deficit irrigation (DI) and rainfed (RF)]. Through the eddy covariance technique, we measured CO2 and water vapor exchanges and determined surface resistances, omega factor, and inherent water use efficiency (IWUE). Additionally, continuous plant growth determinations of leaf area index (LAI) and specific leaf area (SLA) were made over the three cropping systems. The RF potato was a net carbon source (NEE = 187.21 ± 3.84 g C m−2), while both, FI (NEE= −311.96 ± 12.82 g C m−2) and DI (−17.3 ± 4.6 g C m−2) were a net carbon sink. Greater sink activity is due to high fluxes of gross primary productivity (GPP) [where the GPP > ecosystem respiration (Reco)] and evapotranspiration (ET), and the high efficiency in the exchange of carbon and water. Without water limitations, the larger canopy, with greater photosynthetic activity (GPP/Reco > 2) as well as with low internal resistance offers a greater area for water and carbon exchange, and the highly coupled and synchronized ET – GPP fluxes are primarily controlled by the radiative environment. The lower sink capacity of the DI potato crop and the carbon source activity from the RF, are consequences of a smaller area for water and carbon exchange due to the smaller canopy, and a low IWUE from decoupled and desynchronized carbon and water exchange caused by unbalanced restrictions on ET and GPP fluxes. Specifically, at DI potato, ET remained at a high rate, while GPP was reduced by means of non-stomatal limitations. In the rainfed potato, vapor pressure deficit (VPD) played a significant role increasing midday canopy resistance (Rc) up to 13 times compared to irrigated sites, when VPD was around 0.8 kPa. In consequence, ET and GPP fluxes decreased together, but GPP decreased more than ET because of stomatal and non-stomatal limitations.
Safety Profile of Standard and Booster Covid-19 Vaccines in Physicians in Quito-Ecuador. A Cross-Sectional Study
Authors: Flores-Lastra Nancy Jeanneth , Rivadeneira-Dueñas Josue David , Fuenmayor-González Luis Ernesto , Guayasamín-TIpanta Glenda , Jácome-García Michelle , Otzen Tamara , Manterola Carlos
Published: January 2023

More than 600 Healthcare workers died due to COVID-19 infection until January 2022 in Ecuador. Even though the COVID-19 vaccines are safe, local, and systemic reactions were reported among physicians. This study aims to analyze the Adverse events (AEs) of COVID-19 vaccines with an emphasis on homologous and heterologous booster doses. An electronic survey was performed in Quito- Ecuador, directed to physicians who were vaccinated with the three doses of COVID-19 vaccines. 210 participants were analyzed after administering any doses of the vaccines. At least one AE was identified in 60.0% (126/210) of the sample after the first dose, 52.40% (110/210) after the second dose, and 75.2% (158/210) after the booster dose. The most frequent AEs were localized pain, myalgia, headache, and fever. At least one drug was used in 44.3% of the population after the first dose, 37.1% after the second dose, and 63.8% in the booster dose. Heterol-ogous booster produces more AEs compared with homologous booster (80.1% vs. 53.8%), and 77.3% of participants reported that interfered with daily activities. Similar studies agree that reactogenicity occurs mainly with heterologous vaccination compared to ho-mologous vaccination. This situation affected physicians’ performance in daily activities and led them to use medication for the symptoms
Методы повышения и оценки производительности алгоритмов моделирования газодинамических течений на неструктурированных сетках
Authors: Суков Сергей Александрович , Sukov Sergei Aleksandrovich
Published: January 2023

Обсуждается проблема повышения производительности неструктурированных алгоритмов моделирования газодинамических течений на многоядерных процессорах. Рассматриваются детали применения алгоритмов уменьшения ширины ленты
матрицы смежности и реализации схемы вычислений с асинхронным интегрированием по времени. Показана возможность использования симулятора множественно-ассоциативного кэш для сравнительной оценки методов упорядочивания данных.
Описана процедура тестирования быстродействия конечно-объемного алгоритма моделирования уравнений Навье-Стокса на примере расчета задачи сверхзвукового
обтекания сферы на трех смешанных сетках, содержащих от 270 тыс. до 17 млн ячеек.
Disaster Mitigation Program By Radio Nebula FM Palu Central Sulawesi
Authors: Sintya Nur Rahmah , Herman Achmad , Kudratullah Kudratullah
Published: January 2023

This study aims to determine the production process of disaster mitigation education programs by Radio Nebula FM and the continuity of disaster mitigation education programs by Radio Nebula FM. This research is descriptive qualitative with an action research approach. The data collection techniques are observation techniques, interviews, and documentation studies of four informants who have been selected through purposive sampling techniques. The informants who have been selected are employees of PT Radio Nebula Nada, actively involved in the preparation of the 101 mitigation program, and have hosted the 101 mitigation broadcast program.The results showed that the production process of the 101 Radio Nebula mitigation education program had three stages, namely the pre-production, production, and post-production stages. The stages in pre-production consist of discussing ideas and concepts, determining the format of the program, finding topics you want to review while on air and off-air, preparing scripts or scripts, choosing music, and preparing an operational budget. Then the production stage is to maximize the Term of Reference (TOR), take vocals for advertisements, on air for talk shows and news programs as well as outpouring programs (vent) for disaster survivors. Lastly in the post-production stage is the evaluation of the 101 mitigation program by the entire Nebula FM Radio production team. Regarding the continuity of the program, the 101 mitigation program was continued with reduced intensity and the name of the program was changed to Sulteng Round-Up.
Implementation of Guided Inquiry Model with Multimedia to Improve Student Learning Outcomes of Class V MI
Authors: Agustin Nurhaningtyas , Pradana Akhmad Aji
Published: January 2023

The problem of this research is based on such as students who are less active in questioning with the teacher, and students have not been facilitated to carry out various activities such as experimental tools or various experiments, and also the media still does not attract the attention and enthusiasm of students in learning in class. The aims of this study were (1) to describe the application of a guided inquiry model with multimedia to improve science learning outcomes for fifth-grade students at MI Kelopo Telu Tuban (2) to describe science learning outcomes for fifth-grade students at MI Kelopo Telu Tuban (3) to describe improving science learning outcomes in the application of guided inquiry model with multimedia in class V MI Kelopo Telu Tuban. The type of research used is collaborative classroom action research which is carried out in two cycles. Each cycle consists of four stages: planning, implementation, observation, and reflection. The research subjects in this study were students V MI Kelopo Telu Tuban, totaling 15 students. The data used are quantitative in the form of evaluation test results and qualitative data in the form of observations and interview sheets to students regarding the application of guided inquiry models with multimedia. Data collection techniques used are test and non-test techniques, namely observation, and interviews. Data analysis includes data reduction, data presentation, and drawing conclusions. From the results of research on student learning outcomes, each cycle experienced an increase in the application of guided inquiry learning science with this multimedia model. in the first cycle, the average is 77.33, and the completeness is 66.66%, while in the second cycle the average is 82.26 and the completeness is 93.33%. It can be said that classical completeness has been fulfilled because it has reached 75%. Thus, the conclusion of this study is that the application of the guided inquiry model with multimedia can improve learning outcomes in class V MI Kelopo Telu Tuban students.
Implementation of Humanistic Learning Theory in Limited Face-to-face Learning on the Primary Education
Authors: Agustin Nurhaningtyas , Aziz M.Fadloli , Eka Angraeni Ade
Published: January 2023

This study aims to dig deeper into the application of humanistic learning theory in limited face-to-face learning. The approach used in this research was qualitative method. The type of research used was case study. The location of this research was done at MI NU Hidayatun Najah which is located in the city of Tuban. The choice of research location was based on the fact that prior to the limited face-to-face and online learning, before this pandemic MI NU Hidayatun Najah was a full day school. Sources of data in this study were 3 informants which included class teachers and Koran teachers. The instruments in this study were documentation and interview sheets containing seven indicators regarding the implementation of humanistic learning theory in limited face-to-face learning. From the results of research that has been carried out by researchers, it is found that MI NU Hidayatun Najah Tuban has not been maximal in implementing humanistic learning theory in limited face-to-face learning. The results obtained in this study are still very limited and need to be developed in a wider scope. However, the findings in this study are expected to be used as evaluation material for a better implementation of humanistic theory at MI NU Hidayatun Najah Tuban.
Romance como método de conhecimento: leitura de "Sotileza" a partir da ética dos bens humanos básicos
Authors: Siqueira Gilmar , Pinheiro Victor Sales
Published: January 2023

Este artigo investigará as possibilidades do romance como método do conhecimento tal como apresentadas por Julián Marías (1950). Esse método do filósofo espanhol será descrito ainda na introdução. A primeira seção do artigo estará dedicada à análise de um personagem do romance Sotileza, de José María de Pereda (1954). O referencial teórico filosófico que guiará a interpretação do romance será a Teoria Neoclássica da Lei Natural, apresentada na segunda seção. Na terceira seção a estrutura narrativa da razão será comparada à estrutura narrativa da vida humana a fim de verificar se (e como) os bens humanos básicos descritos pela teoria Neoclássica da Lei Natural são percebidos e buscados no tempo – dramaticamente. A conclusão do artigo cuidará das reverberações desta pesquisa na compreensão ética dos direitos humanos.
Reservoir Permeability Prediction Based on Analogy and Machine Learning Methods: Field Cases in DLG Block of Jing’an Oilfield, China
Authors: Guo Qiao , Cheng Shiqing , Zeng Fenghuang , Wang Yang , Lu Chuan , Tan Chaodong , Li Guiliang
Published: January 2023

Reservoir permeability, generally determined by experimental or well testing methods, is an essential parameter in the oil and gas field development. In this paper, we present a novel analogy and machine learning method to predict reservoir permeability. Firstly, the core test and production data of other 24 blocks (analog blocks) are counted according to the DLG block (target block) of Jing’an Oilfield, and the permeability analogy parameters including porosity, shale content, reservoir thickness, oil saturation, liquid production, and production pressure difference are optimized by Pearson and principal component analysis. Then, the fuzzy matter element method is used to calculate the similarity between the target block and analog blocks. According to the similarity calculation results, reservoir permeability of DLG block is predicted by reservoir engineering method (the relationship between core permeability and porosity of QK-D7 in similar blocks) and machine learning method (random forest, gradient boosting decision tree, light gradient boosting machine, and categorical boosting). By comparing the prediction accuracy of the two methods through the evaluation index determination coefficient (R2) and root mean square error (RMSE), the CatBoost model has higher accuracy in predicting reservoir permeability, with R2 of 0.951 and RMSE of 0.139. Finally, the CatBoost model is selected to predict reservoir permeability of 121 oil wells in the DLG block. This work uses simple logging and production data to quickly and accurately predict reservoir permeability without coring and testing. At the same time, the prediction results are well applied to the formulation of DLG block development technology strategy, which provides a new idea for the application of machine learning to predict oilfield parameters.
Behavioural economic interventions to reduce health care appointment non-attendance: A systematic review
Authors: Werner Kalin , Alsuhaibani Sara Abdulrahman , Alsukait Reem Fahad M , Herbst Christopher H. , Lin Tracy Kuo
Published: January 2023

Background
Appointment non-attendance – often referred to as “missed appointments”, “patient no-show”, or “did not attend (DNA)” – causes volatility in health systems around the world. Of the different approaches that can be adopted to reduce patient non-attendance, behavioural economics-oriented mechanisms (i.e., psychological, cognitive, emotional, and social factors that may impact individual decisions) are reasoned to be better suited in such contexts – where the need is to persuade, nudge, and/ or incentivize patients to honour their scheduled appointment. The aim of this systematic literature review is to identify and summarize the published evidence on the use and effectiveness of behavioural economic interventions to reduce no-shows for health care appointments.
Methods
We systematically searched four databases (PubMed/Medline, Cochrane, Embase, Scopus, and Web of Science) for published and grey literature on behavioural economic strategies to reduce no-shows for health care appointments. Eligible studies met four criteria for inclusion; they were (1) available in English, Spanish, or French, (2) assessed behavioural economics interventions, (3) objectively measured a behavioural outcome (as opposed to attitudes or preferences), and (4) used a randomized and controlled or quasi-experimental study design.
Results
Our initial search of the five databases identified 1,225 articles. After screening studies for inclusion criteria and assessing risk of bias, 61 studies were included in our final analysis. Data was extracted using a predefined 19-item extraction matrix. All studies assessed ambulatory or outpatient care services, although a variety of hospital departments or appointment types. The most common behaviour change intervention assessed was the use of reminders (n = 56). Results were mixed regarding the most effective methods of delivering reminders. There is significant evidence supporting the effectiveness of reminders (either by SMS, telephone, or mail) across various settings. However, there is a lack of evidence regarding alternative interventions and efforts to address other heuristics, leaving a majority of behavioural economic approaches unused and unassessed.
Conclusion
The studies in our review reflect a lack of diversity in intervention approaches but point to the effectiveness of reminder systems in reducing no-show rates across a variety of medical departments. We recommend future studies to test additional behavioural economic interventions that have not been used, tested, and/or published before.
Intratubular crystal formation in the exposed dentin from nano-sized calcium silicate for dentin hypersensitivity treatment
Authors: Jeon Mi-Jeong , Park Jeong-Won , Seo Deog-Gyu
Published: January 2023

The aim of this study is to evaluate intratubular crystal formation from the experimental material consisting of dicalcium silicate (C2S) and tricalcium silicate (C3S) with nano-scaled particle size. A total of twenty-four specimens were made by isolating 8 mm of the cervical part centered at the cementoenamel junction of extracted premolars. Twelve specimens were not treated and considered as control. The experimental material was applied to the other twelve specimens by brushing for 10,000 strokes. Each group was randomly divided into four subgroups according to the period of immersion in phosphate buffer saline (PBS) for 1, 30, 60, and 90 days each. The specimens were sectioned longitudinally and examined with scanning electron microscopy and energy dispersion X-ray spectroscopy. The intratubular crystal were formed in PBS and densely filled the dentinal tubules over time. The crystal formation occurred at a depth of more than 50 μm from the dentin surface. The Ca/P ratio of formed intratubular crystals was 1.68 after three months. The experimental material consisting of C2S and C3S with a nanoscale particle size can form hydroxyapatite-like crystals in dentinal tubules in PBS, and there is a possibility of reducing dentin hypersensitivity by blocking the dentinal fluid flow.
Do different methods of specimen extraction in laparoscopic low rectal cancer surgery affect loop ileostomy closure?
Authors: Chen Haipeng , Huang Fei , Yang Ming , Zhao Zhixun , Guan Xu , Liu Zheng , Jiang Zheng , Liu Qian , Zheng Zhaoxu , Wang Xishan
Published: January 2023

Introduction:
The aim of this study was to compare whether laparoscopic low rectal cancer surgery with three different specimen extraction methods affects loop ileostomy closure.
Materials and methods
A consecutive series of patients with low rectal cancer who underwent laparoscopic low anterior resection plus protective loop ileostomy (LAR-PLI) were enrolled. Three main techniques, namely specimen extraction through auxiliary incision (EXAI), specimen extraction through stoma incision (EXSI), and specimen eversion and extra-abdominal resection (EVER), were employed. The postoperative outcomes of the three techniques and the impact on loop ileostomy closure were compared.
Results
In all, 254 patients were enrolled in this study: 104 (40.9%) in the EXAI group, 104 (40.9%) in the EXSI group, and 46 (18.1%) in the EVER group. For primary surgery, EXAI group had significantly longer operative time (P < 0.001), more intraoperative bleeding (P < 0.001), longer length of abdominal incision (P༜0.001), longer time to first flatus (P < 0.001), longer time to first defecation (P < 0.001), longer time to first eat (P < 0.001), and longer postoperative hospital stays (P = 0.005) than the EXSI and EVER groups. The primary postoperative complication rate in the EXAI and EVER group was significantly higher than in the EXSI group (P = 0.005). In loop ileostomy closure, EXAI group had significantly longer operative time (P = 0.001), more bleeding volume and longer postoperative hospital stays (P < 0.001) than the EXSI and EVER groups.
Conclusions
All three techniques of LAR-PLI for low rectal cancer were safe and feasible, but specimen extraction via EXAI had no advantages in terms of early postoperative recovery and loop ileostomy closure.
Renewable energy, forest cover, export diversification and ecological footprint: A machine learning application in moderating eco-innovations on agriculture in BRICS-T economies
Authors: PADHAN HEMACHANDRA , Ghosh Sudeshna , Hammoudeh Shawkat
Published: January 2023

According to UN Climate Change Conference (UNFCCC, 2022), COP26 summit the global leaders urged the nations to develop the production capability and enhance the domestic capacity through technological progression and structural transformation. The set of BRICS-T economies (Brazil, Russia, India, China, South Africa and Turkey) account for 43 per cent of the global population and occupy around 30 per cent of land area across the global landscape in 2017. Additionally, they account for about 40 per cent of global greenhouse gas emissions in 2017. Therefore, this study investigates the role of renewable energy, export diversification on ecological footprint for BRICS-T countries over a period of 1990–2019. This study also examines the moderating effect of ecological-innovation on agriculture in BRICS-T countries. We use the parametric and non-parametric econometrics techniques to empirically imply the relationship between these series. According to Augmented Mean Group and Kernel Regularized Least Square methods, the role of economic growth, agriculture, export diversification, ecological innovation and the moderating effect of ecological innovations on agriculture impact the ecological footprint in the long-run respectively. Indeed, non-parametric time-varying panel data models with fixed effects is used to check the robustness. The policy insights have been explained in the conclusion section.
JEL classification : Q57; Q2; Q55; C14; C01
Hexokinase-1 mitochondrial dissociation and protein O-GlcNAcylation drive heart failure with preserved ejection fraction
Authors: Tatekoshi Yuki , Shapiro Jason , Liu Mingyang , Bianco George , Tatekoshi Ayumi , De Jesus Adam , Koleini Navid , Wasserstrom J. Andrew , Dillmann Wolfgang , Weinberg Samuel , Ardehali Hossein
Published: January 2023

The authors have requested that this preprint be
removed from Research Square as it was inadvertently
submitted.
Chasing maximal pro-p Galois groups via 1-cyclotomicity
Authors: Quadrelli Claudio
Published: January 2023

Let p be a prime. We prove that certain amalgamated free pro-p products of Demushkin groups with pro-p cyclic amalgam cannot give rise to a 1-cyclotomic oriented pro-p group, and thus do not occur as maximal pro-p Galois groups of fields containing a root of 1 of order p. We show that other cohomological obstructions which are used to detect pro-p groups that are not maximal pro-p Galois groups - the quadraticity of Z/pZ-cohomology and the vanishing of Massey products - fail with the above pro-p groups. Finally, we prove that the Minac-Tan pro-p group cannot give rise to a 1-cyclotomic oriented pro-p group, and we conjecture that every 1-cyclotomic oriented pro-p group satisfy the strong n-Massey vanishing property for n = 3, 4.
Mendelian randomization study to investigate the causal relationship between plasma homocysteine and chronic obstructive pulmonary disease
Authors: Hu Yanlan , Wang Juntao , Zeng Jun , Li Quan , Zhang Caihong , Hao Wenjie , He Lanfen , song xingyue , yan shijiao , lv chuzhu
Published: January 2023

Background
Several studies have shown an association between plasma homocysteine levels and chronic obstructive pulmonary disease (COPD). It is not clear whether there is a causal association. A two-sample Mendelian randomization (MR) based method was used to further explore the causal association between plasma homocysteine and COPD.
Methods
Several studies have shown an association between plasma homocysteine levels and COPD. It is not clear whether there is a causal association.we performed a second data analysis using pooled data from published genome-wide association studies (GWASs) .we used genome-wide meta-analysis (n = 44147) to obtain genome-wide single nucleotide polypeptides (SNPs) associated with plasma homocysteine levels as instrumental variables. We used two-sample MR to study plasma homocysteine and COPD and COPD related diseases. MR analysis was performed by the random effects inverse variance weighting method and heterogeneity tests and pleiotropy tests were performed to evaluate the robustness of our findings.
Results
By two-sample MR analysis, We did not find causal associations between genetically predicted plasma homocysteine levels and COPD and COPD related diseases. In COPD hospital admissions,(OR = 1.06,95%CI 0.91–1.24,P = 0.42),asthma/COPD,(OR = 0.97,95%CI 0.89–1.06, P = 0.55),COPD related to chronic (opportunist) infection(OR = 1.50,95%CI 0.57–3.99,P = 0.41),COPD/asthma/ILD-related pneumonia or pneumonia-derived (OR = 0.93,95%CI 0.86–1.02,P = 0.13),COPD-related respiratory insufficiency(OR = 1.00,95%CI 0.7–1.44,P = 0.99), no heterogeneity and horizontal pleiotropy werefound.
Conclusions
Our study shows that genetically predicted plasma homocysteine levels are not causally associated with COPD, contrary to previous observational findings.As homocysteine is known to have deleterious effects on endothelial function and vascular homeostasis, further studies are needed to investigate whether additional factors mediate the association between homocysteine and COPD.
The role of the PLGF in the management of pregnancies complicated with fetal microsomia.
Authors: Souka Athena , Chatziioannou Maria Ioanna , Pegkou Afrodite , Antsaklis Panagiotis , Daskalakis George
Published: January 2023

Purpose
To explore the contribution of maternal and fetal parameters in predicting the time interval between diagnosis and development of adverse events leading to delivery in singleton pregnancies complicated with fetal microsomia.
Methods
Prospective study on singleton pregnancies referred to a tertiary centre because of suspicion of fetal smallness in the third trimester. The study cohort included cases with fetal abdominal circumference (AC) ≤ 10th centile or estimated fetal weight ≤ 10th centile or umbilical artery pulsatitlity index ≥ 90th centile. Development of pre-eclampsia, fetal demise and fetal deterioration diagnosed by fetal Doppler studies or fetal heart rate monitoring and leading to delivery were considered as adverse events. Maternal demographics, obctetric history, blood pressure, serum PLGF and fetal Doppler studies were explored as predictors of the time interval between the first visit to the clinic and the diagnosis of complications.
Results
In 59 women the median incubation period from presentation to the clinic to an adverse event was 6,2 weeks, whereas half of the pregnancies (52.5%) did not develop any adverse event. PLGF was the strongest predictor of adverse events. Both PLGF in raw values and PLGF MOM had equally good predictive ability (AUC 0.82 and 0.78 respectively). Optimal cut-off points were 177.7pg/ml for PLGF raw values (sensitivity 83% and specificity 66.7%) and 0.277 MoM (sensitivity 76% and specificity 86.7%). On multiple Cox regression analysis maternal systolic blood pressure and PLGF and fetal increased umbilical artery PI and reduced CP ratio were independently associated with adverse events. Half of the pregnancies with low PLGF and only one in ten with high PLGF were delivered within two weeks after the initial visit.
Conclusion
Half of the pregnancies carrying a small fetus in the third trimester will not develop maternal or fetal complications. PLGF is a strong predictor of adverse events that can be used to customize antenatal care.
Comparable Outcomes Using Oral Dydrogesterone versus Intramuscular Progesterone in Frozen Embryo Transfer: a Retrospective Cohort Study
Authors: Bachar Gal , Haskia Chen , Fainaru Ofer
Published: January 2023

Background
Optimal intensive luteal support in frozen embryo transfer (FET) cycles in which a corpus luteum is not present has not been determined and several treatment regimens are currently practiced. Previous reports suggest that vaginal progesterone alone is probably insufficient. The use of intramuscular progesterone is considered efficacious but much less tolerable. The objective of this study was to compare a more tolerable regimen using micronized vaginal progesterone (MVP) and oral dydrogesterone versus MVP and intramuscular progesterone (IM) for luteal support.
Methods
A retrospective study of patients undergoing single blastocyst FET in a tertiary center IVF unit. All patients (n = 100) received oral estradiol in the follicular phase and supplemented with MVP for luteal phase support. One group (n = 50) received additional dydrogesterone (10 mg TID) and the other (n = 50) intramuscular progesterone (100 mg every 3 days).
Results
The two groups were similar with regard to age; BMI; infertility etiology and duration; and basal hormonal levels. Biochemical pregnancy rates (34% vs 42%, p = 0.54) and clinical pregnancy rates (26% vs. 36%, p = 0.39) were lower in the MVP + oral dydrogesterone group as compared to the MVP + IM progesterone group. Nevertheless, this difference was not statistically significant. Abortion rates were similar (2%) and there were no ectopic pregnancies in both groups.
Conclusion
This retrospective cohort study demonstrates noninferiority of MVP and oral dydrogesterone as compared to MVP and intramuscular progesterone for luteal support in FET cycles. The better profile of adverse effects and tolerability makes it a suitable protocol for FET.
Prevalence of polycystic ovary syndrome and its clinical and hormonal profile in young females with type 1 diabetes mellitus: experience from a teaching Institution of India
Authors: Dominic Nibu , Sharma Lokesh , Dabadghao Preeti , Mohindra Namita
Published: January 2023

Objective
To investigate the prevalence of polycystic ovary syndrome and its clinical and hormonal profile in females with type 1 diabetes.
Materials and methods
65 T1DM females were evaluated for presence of PCOS and compared with age and BMI matched females with PCOS without diabetes.
Results
According to Rotterdam criteria 18/65 (27%) had PCOS. Prevalence of androgen excess, hirsutism, menstrual dysfunction and PCOM was 26%, 3%, 21% and 52% respectively. The females with T1DM who had PCOS did not differ from group without PCOS. Among those who had PCOS, the mean daily insulin dose (U/kg/day) was higher in girls who had post-pubertal onset of diabetes (median, IQR; 1.2, 0.95-1.56) vs pre-pubertal (0.81, 0.75-1.2) (p=0.055) which was close to statistical significance.
When the group of T1DM with PCOS was compared with PCOS females without diabetes, they had significantly lower hirsutism score (median, IQR; 1.5, 0-3 vs. 11.5, 0 – 16.5, p= 0.04), significantly higher waist hip ratio (0.91, 0.89-0.99 vs. 0.86, 0.80 – 0.89, p= 0.004) and SHBG (in nmol, 54.4, 38-86.2 vs. 28.3, 20.4-37.4, p= 0.004)
Conclusion
Females with T1DM have a high prevalence of menstrual abnormalities, hyperandrogenism and PCOS which is not related to metabolic control, age of onset of diabetes or insulin dose.
Influence of benign prostatic hyperplasia patterns detected with MRI on the clinical outcome after prostatic artery embolization
Authors: Boschheidgen Matthias , Al-Monajjed Rouvier , Minko Peter , Jannusch Kai , Ullrich Tim , Radke Karl-Ludger , Michalski Rene , Radtke Jan Phillip , Albers Peter , Antoch Gerald , Schimmöller Lars
Published: January 2023

Background
To investigate the influence of MRI hyperplasia patterns in benign prostate hyperplasia (BPH) and tissue composition on outcome parameters in a collective of patients undergoing prostate artery embolization (PAE).
Materials & Methods
This retrospective study included patients (median age 72y) with the diagnosis of BPH, who underwent magnetic resonance imaging (MRI) of the prostate followed by PAE at a single centre. MRI scans were evaluated and BPH patterns were determined according to Wasserman type and a modified BPH classification. Additionally, scans were evaluated regarding the presence of adenomatous-dominant benign prostatic hyperplasia (AdBPH). Lower urinary tract symptoms (LUTS) were assessed using the International Prostate Symptom Score (IPSS) and urinary flow rate (Qmax). Follow-up examination included MRI and clinical outcome.
Results
For clinical outcome at follow-up, IPSS showed median reduction of 54% (IQR 41 - 75%) and Qmax improved by 4.1 ml/s. We noted significant reduction in volume, intraprostatic protrusion and prostatic urethra angle in our collective (p<0.01). Median volume reduction was 25% (IQR 15% - 34%). Multiple linear regression model showed significant effect of high initial volume on reduction in IPSS scores after treatment (p<0.01). Presence of AdBPH was significantly associated with both volume loss and clinical improvement in terms of IPSS reduction (p<0.01). Neither BPH patterns based on the Wassermann type nor modified BPH classifications were significantly related with postinterventional IPSS and volume loss.
Conclusions
Men benefit from PAE regardless the macroscopic BPH MRI pattern. Preinterventional prostate volume, presence of AdBPH on MRI, and IPSS should be considered for outcome prognosis after prostatic artery embolization.
Genetic analysis and QTL mapping for silique density in rapeseed (Brassica napus L.)
Authors: Ma Xingrong , Wang Jinhua , Gu Yongfen , Fang Pengpeng , Nie Wenjing , Luo Ruirui , Liu Jin , Qian Wei , Mei Jiaqin
Published: January 2023

Silique density is one of the critical factors to determine seed yield and plant architecture in rapeseed (Brassica napus L.), however, the genetic control of this trait is largely unknown. In this study, the genetic model for silique density on main inflorescence (SDMI) of rapeseed was estimated according to the phenotypic data of P1 (an inbreed line with high SDMI), P2 (an inbreed line with low SDMI), F1, F2, BC1P1 and BC1P2 populations, revealing that SDMI is probably controlled by multi minor genes with or without major gene. The QTLs for SDMI and its component characters including silique number on main inflorescence (SNMI) and main inflorescence length (MIL) were consequently mapped from a DH population derived from P1 and P2 by using a genetic linkage map constructed by RAD-seq technology. A total of eight, 14 and three QTLs were identified for SDMI, SNMI and MIL under three environments, respectively, with an overlap among SDMI and SNMI in 55.7-75.4 cM on linkage group C06 which corresponding to 11.6-27.3 Mb on chromosome C06. Genomic resequencing was further conducted between a high- and a low-SDMI pool constructed from the DH population, and QTL-seq analysis identified a 0.15-Mb interval (25.98-26.13 Mb) from the C06-QTL region aforementioned. Transcriptome sequencing and qRT-PCR identified one possible candidate gene (BnARGOS) from the 0.15-Mb interval. This study will provide novel insights into the genetic basis of SD in rapeseed.
Tailoring the resonant modes in liquid crystal based all-dielectric metasurfaces
Authors: Sakhare Pratiksha A , Atmakuri Madhunika , DONTABHAKTUNI JAYASRI
Published: January 2023

High refractive index dielectic metasurfaces are being increasingly studied for their novel light-matter interactions such as Huygen's lens, absolute transmission and complete absorption. Liquid crystal is a versatile medium with high dielectric anisotropy and hence interaction of light with the dielectric metasurfaces immersed in liquid crystal medium show complex behaviour compared to isotropic media. Most of the investigations on liquid crystal based electromagnetic response of dielectric metasurfaces focus on tunability of resonant frequencies and switching between the resonant states as a function of external stimuli such as electric field, temperature, etc. In the current work we present a detailed investigation of scattering response, near-field and far-field radiation profiles of cubic Tellurium metasurfaces as a function of liquid crystal orientations in infrared frequencies.We show that the near-field and far-field radiation profiles of primary resonant modes - electric dipoles and magnetic dipoles reorient as a function of liquid crystal orientations. In particular, we study the effect of liquid crystal orientations on novel non-radiative states called anapoles. It is observed that liquid crystal orientations effect the excitation and orientation of anapole states within the Tellurium structures. This paves way for design of an electrically-driven switch between non-radiative and radiative states. Further, controlling the near-field and far-field radiation profiles opens up possibilities in designing liquid crystal based tunable multi-functional metasurfaces which can change the directionality of incident light.
Activator-blocker model of transcriptional regulation by pioneer-like factors
Authors: Onichtchouk Daria , Riesle Aileen , Gao Meijiang , Rosenblatt Marcus , Hermes Jacques , Hass Helge , Gebhard Anna , Veil Marina , Gruening Bjoern , Timmer Jens
Published: January 2023

Zygotic genome activation (ZGA) in the development of flies, fish, frogs and mammals depends on pioneer-like transcription factors (TFs). Those TFs create open chromatin regions, promote histone acetylation on enhancers, and activate transcription. Here, we use the panel of single, double and triple mutants for zebrafish genome activators Pou5f3, Sox19b and Nanog, multi-omics and mathematical modeling to investigate the combinatorial mechanisms of genome activation. We show that Pou5f3 and Nanog act differently on synergistic and antagonistic enhancer types. Pou5f3 and Nanog both bind as pioneers on synergistic enhancers, promote histone acetylation and activate transcription. Antagonistic enhancers are activated by pioneer binding of one of these factors. The other TF binds as non-pioneer, competes with the activator and blocks all its effects, partially or completely. This activator-blocker mechanism mutually restricts widespread transcriptional activation by Pou5f3 and Nanog and prevents premature expression of late developmental regulators in the early embryo
Incommensurate charge-stripe correlations in the kagome superconductor CsV3Sb5-xSnx
Authors: Wilson Stephen , Kautzsch Linus , Oey Yuzki , Li Hong , Ren Zheng , Ortiz Brenden , Pokharel Ganesh , Seshadri Ram , Ruff Jacob , Kongruengkit} Terawit , Harter John , Wang Ziqiang , Zeljkovic Ilija
Published: January 2023

The new class of AV3Sb5 (A=K, Rb, Cs) kagome metals host unconventional charge density wave states seemingly intertwined with their low temperature superconducting phases. The nature of the coupling between these two states and the potential presence of nearby, competing charge instabilities however remain open questions. This phenomenology is strikingly highlighted by the formation of two ''domes” in the superconducting transition temperature upon hole-doping CsV3Sb5. Here we track the evolution of charge correlations upon the suppression of long-range charge density wave order in the first dome and into the second of the hole-doped kagome superconductor CsV3Sb5-xSnx. Initially, hole-doping drives interlayer charge correlations to become short-ranged with their periodicity diminished along the interlayer direction. Beyond the peak of the first superconducting dome, the parent charge density wave state vanishes and incommensurate, quasi-1D charge correlations are stabilized in its place. These competing, unidirectional charge correlations demonstrate an inherent electronic rotational symmetry breaking in CsV3Sb5, and reveal a complex landscape of charge correlations within its electronic phase diagram. Our data suggest an inherent 2kf charge instability and competing charge orders in the AV3Sb5 class of kagome superconductors.
Assessment of factors influencing physicians’ intention to prescribe transfusion using the theory of planned behavior
Authors: Liao Yu-Han , Tang Kung-Pei , Chou Chih-Yu , Kuo Chien-Feng , Tsai Shin-Yi
Published: January 2023

Background:
Blood shortage is a persistent problem affecting Taiwan’s health-care system. The theory of planned behavior (TPB) has been commonly used in studies of health advocacy. The purpose of this study was to develop a questionnaire measuring clinicians’ intention to prescribe transfusion based on the TPB.
Method:
A questionnaire comprising 15 items for assessing clinicians’ intention to prescribe blood transfusion was developed, and it collected demographic characteristics tested patient blood management (PBM) and perceived knowledge of PBM. Furthermore, it contained four subscales related to the TPB. A total of 129 clinicians participated in this pilot study between July and December, 2020. Item analysis and exploratory factor analysis were conducted to examine the validity and reliability of this measurement instrument.
Results:
The results indicated no statistically significant correlations between the demographic characteristics and test scores. Regarding perceived knowledge, the results of a one-way analysis of variance revealed that the effect of age, hierarchy of doctors, and education level was significant. In terms of subjective norms, a significant effect for education level was noted [t (129) = 2.28, p < 0.05], with graduate school graduates receiving higher scores than college graduates. An analysis of variance demonstrated the effect of hierarchy, education level, and medical specialty on perceived behavioral control. The results of the regression analyses revealed that perceived knowledge (β = 0.32, p < 0.01) and subjective norms (β = 0.22, p < 0.05) were significantly related to clinicians’ behavioral intention.
Conclusions:
This study revealed that factors affecting clinicians’ blood transfusion management can be explained using the TPB-based questionnaire. This study demonstrated that physicians’ perception of whether most people approve of PBM and their self-assessment of their PBM knowledge affect their intention to proceed with PBM. According to this finding, a support system among physicians must be established and maintained to increase physician’s confidence in promoting PBM.
Genetic analysis of stripe rust resistance in CIMMYT common wheat line KFA/2*KACHU under Chinese rust environment
Authors: Lan Caixia , Yin Yuruo , Yuan Chan , Zhang Yichen , Li Shunda , Bai Bin , Wu Ling , Ravi Sing
Published: January 2023

Breeding resistant wheat variety is the most economic and efficient way to manage wheat stripe rust, while identification of new stripe rust resistance gene and development the molecular markers will be very useful for wheat breeder in the breeding program. In the present study, a recombinant inbred line (RIL) population derived from a cross of the resistant parent KFA/2*KACHU and susceptible parent Apav#1 was used to map stripe rust resistance loci. In combination of GBS genotyping platform and BSR-Seq method, we mapped a new race-specific stripe rust resistance gene on wheat chromosome 5BL at the seedling stage, temporarily named as YrK. TraesCS5B02G330700 encoded a receptor-like kinase was considered as the key candidate gene of YrK based on virus induced gene silencing (VIGS) method. Its expression showed a significant up-regulated at 24h after inoculation and the functional molecular markers were developed based on the polymorphic SNPs in the CDS region. In addition, a total of four adult plant resistance (APR) loci were identified on wheat chromosome 1BL, 2AS, 2BS and 4AL, respectively. Among these, QYr.hazu-1BL and QYr.hazu-2AS was verified as the known resistance genes Lr46/Yr29/Pm39 and Yr17, respectively. QYr.hazu-2BS was a new APR locus and the closely linked SNP markers were converted into breeder-friendly KASP markers.