bluuebunny/crossref_metadata_2025 huggingface dataset:
Band gaps engineering of the lead-free perovskites FABI3 (B= Sn, Ge or Pb) materials for all Pb-free Tandem Solar Cells: first principle investigation of structural and electronic properties
Authors: Arfaoui Youssef El , Khenfouch Mohammed , Habiballah Nabil
Published: October 2023

Pb-free perovskites are novel compounds that are currently most studied for their photovoltaic application in solar cells due to their less toxicity. In this paper, we are studying the Hybrid-Organic-Inorganic perovskite (HOIP) for photovoltaic application. In fact, we study and discuss the structural and electronic properties of the perovskite FABI3 (B= Sn, Ge or Pb) applying the DFT method executed in the Quantum Espresso framework. The band structure these perovskites has been presented; it is showed that these perovskits has a semi-conductor nature, with a band gap value 1.36eV for FASnI3, 1.72eV for FAGeI3 and 1.61eV for FAPbI3. Also, the DOS and PDOS have been presented and discussed of each one of these materials. Indeed, we investigate the structural properties of these perovskites and demonstrated that the optimized value of lattice parameter is 6.35Å for the FASnI3, While, for the FAGeI3, this value is 6.3Å. And 6.5Å for FAPbI3. Moreover, the impact of the lattice parameter on the band gap value of FABI3 (B =Sn, Ge or Pb) has been investigated, it is demonstrated that the lattice parameter increases, the band gap increases. The results of this work can be utilized as a guideline for the development of new efficient, lead-free perovskite devices including tandem solar cells.
Effects of Romosozumab on Bone Mineral Density and Fractures; a Univariate Meta Analysis
Authors: Dilshani S. D. M. , Jayasekara L. A. L. W. , Liyanage G. , Lekamwasam S.
Published: October 2023

Purpose
Romosozumab, a monoclonal antibody has been approved for the treatment of postmenopausal women with osteoporosis and high fracture risk. This meta-analysis evaluated the effect of romosozumab on Bone Mineral Density (BMD) and fracture occurrence in postmenopausal women with osteoporosis.
Methods
A systematic search was done adhered to the PRISMA guidelines in PubMed, Ovid and Clinicaltrials.gov and eligible studies were selected. In addition to details related to study participants, changes in BMD at the lumber spine (LS), total hip (TH) and femoral neck (FN) and the occurrence of fractures during the study period were extracted. The mean differences of BMDs between the two study groups and odds ratios (OR) of fractures were considered as the outcome of studies.
Results
Of the 11 potentially eligible articles, four were included in the meta-analysis. Romosozumab therapy for 12 months increased mean BMD at the LS by 12.7% (95% CI, 9.7, 15.6), TH by 4.8% (95% CI, 3.3,6.3) and FN by 4.3% (95% CI, 3.1, 5.5). Treatment with romosozumab was associated with 54% and 25% reduction of new vertebral (OR = 0.46, CI, 0.23,0.91) and non-vertebral fractures (OR = 0.75, CI, 0.53,1.06) respectively at the end of 12months.
Conclusion
In conclusion, romosozumab significantly increases BMD at LS, TH and FN and reduces the risk of new vertebral and non-vertebral fractures in postmenopausal women with osteoporosis.
Double-walled carbon nanotubes synthesis by pulsed electric arc discharge with spinning anode
Authors: Saucedo-Jimenez David , Medina-Sánchez Isaac , Padilla-Pérez Diego A. , Couder-Castañeda Carlos , Sanchez Jose Luis Luna
Published: October 2023

This research demonstrates that double-walled carbon nanotubes can be synthesized using the pulsed electric arc discharge with the spinning anode method (PEADSA). This method can be arranged in various experimental configurations to synthesize carbon nanostructures. With this method, the frequency of the pulsed discharge can be controlled, as well as the discharge onset, which directly affects the nucleation and growth of carbon nanotubes. Scanning (SEM) and transmission (TEM) electron microscopy and Raman spectroscopy were used. The desired double-walled carbon nanotubes were obtained with an internal diameter of 0.82 – 1.52 nm and an external diameter of 1.52 – 2.33 nm.
WITHDRAWN: An efficient dual layer data aggregation scheme in clustered wireless sensor networks
Authors: Yang Fenting , Xu Zhen , Yang Lei
Published: October 2023

In wireless sensor network monitoring system, redundant data from sluggish environmental changes and overlapping sensing ranges can increase the volume of data sent by nodes, degrade the efficiency of information collection, and lead to the death of sensor nodes. In order to reduce energy consumption of sensor nodes and prolong the life of wireless sensor networks, this paper proposed a dual layer intra-cluster data fusion scheme based on ring buffer (DLIDF). To reduce redundant data and temporary anomalous data while guaranteeing the temporal coherence of data, the source nodes employ a binarized similarity function and sliding quartile detection based on ring buffer. Based on the improved support degree function of weighted Pearson distance, the cluster head node performs a weighted fusion on the data received from the source nodes. Experiment results reveal that the scheme proposed in this paper has clear advantages in three aspects: the number of remaining nodes, the residual energy, and the number of packets transmitted.
Investigating flow induced mechanics of strain-engineered microcantilevers integrated in a flow-through system
Authors: Islam Mohammad S. , Challa Sushmita , Wei Danming , Beharic Jasmin , Popa Dan O. , Harnett Cindy K.
Published: October 2023

In this work we report the fabrication of stress-driven curled-up microcantilevers based on a metal-oxide bilayer design and their mechanical characterization in a flow-through system. Microcantilever arrays are realized by using conventional micromachining techniques involving optical lithography and etching processes. Due to the geometry of the out-of-plane curled cantilever, the load applied by the fluid flow is distributed along its body. These cantilevers showed mechanical robustness at flow velocity and drag force ranges of 0.48–5.7 mm/s and 0.35–4.23 µN, respectively for operation with glycerol. This fluid-driven approach enables us to measure multiple structures at once and get statistics on their mechanical performance, durability, and applicability in different devices.
Oral expression following COVID-19: A systematic review
Authors: Gibeili Chloé , Marchesseau Louis , Boisramé Sylvie
Published: October 2023

Objective: The aim of this study was to systematically review the literature to gather the oral manifestations of coronavirus disease-2019 (Covid-19), evaluate a direct accountability for severe acute respiratory syndrome-coronavirus 2 (SARS-Cov2), and determine a correlation between ACE2 receptor oral tissue density and Covid-19 lesions. Materials and Methods: PubMed and Web of Science were searched from January 2020 to April 2022; the principal outcome was oral manifestations in PCR-tested patients positive for Covid-19. PRISMA protocol was used to evaluate the results. Results: Among the 535 articles reviewed, 80 were included and analyzed. Oral ulcerations were found most frequently as dermatologic lesions, followed by erythema and macules (as a harbinger or not of ulcerations). Direct accountability was difficult to establish because of the systemic proinflammatory stimulation following Covid-19. Lesion topography was essentially lingual and palatal according to an ACE2 high-density tissue level and recent histologic evidence of SARS-Cov2 presence in the lesions. A direct inflammation of the salivary glands was also reported. Conclusion: Evidence to distinguish direct and indirect etiologies of the SARS-Cov2 virus following Covid-19 infection was poor. It could be deepened by investigating the presence of the SARS-Cov2 virus in tissue lesions and tissue disorders activated by ACE2 pathways.
Unravelling Role of the Microwave Sintering Effects on Microstructure, Density, and Corrosion Behavior of porous Ti-13.3at.% Nb Shape Memory Alloys
Authors: Ibrahim Mustafa K. , Al-Humairi Safaa N. Saud
Published: October 2023

This study investigates the impact of microwave sintering on the microstructure, density, and corrosion behaviour of porous Ti-13.3at.% Nb shape memory alloys (SMAs). The alloys were subjected to microwave sintering at 800°C and 1100°C for 20 and 40 minutes, focusing on understanding the structural changes and corrosion resistance. Microstructural characterization, including scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), and electron backscatter diffraction (EBSD), were performed. The results revealed the formation of two distinct needle-like morphologies: straight and cross-linked needles (βSC) and irregular lines or spaghetti-like needles (βS). The area fraction of these needle structures increased with prolonged sintering duration and elevated sintering temperature, indicating enhanced diffusion between Ti and Nb elements. Density measurements showed a range of 73-75.5%, with the highest density (75.5%) achieved for samples sintered at 800°C for 40 minutes. However, a lower density (73%) was observed for samples sintered at 1100°C for 20 minutes, attributed to the rapid heating rate of microwave sintering. Corrosion characteristics were evaluated using potentiodynamic polarization (PDP) and electrochemical impedance spectra (EIS) in simulated body fluid (SBF). The corrosion behaviour was significantly influenced by sintering temperature rather than sintering duration. Samples sintered at 1100°C exhibited larger capacitive loops on their Nyquist plots compared to those sintered at 800°C, indicating improved corrosion resistance. With the 800°C sintering temperature, the sintering duration had a less pronounced impact on corrosion behaviour. The EBSD analysis revealed that Ti-Nb diffusion predominantly occurred at grain boundaries, with reduced diffusion in areas further from the grain boundaries. In conclusion, this study elucidates the profound influence of microwave sintering parameters on the microstructure and corrosion behaviour of porous Ti-13.3at.% Nb SMAs. The findings provide valuable insights into optimizing the sintering process for enhanced material properties, offering potential applications in biocompatible and corrosion-resistant engineering components.
Nuclear factor E2-related factor 2 knockdown alters adipose-phenotype and increases expression of genes involved in longevity in 3T3-L1 cells
Authors: Yuan Xiao-yang , Wang Hua-long , Xie Bingchuan , Ding Yan
Published: October 2023

This study aimed to assess in vitro the impacts of Nuclear factor E2-related factor 2 (Nrf2) knockdown on the transformation of adipose phenotype and the possible mechanisms of resistance to aging in 3T3-L1 cells. In the current study, the Nrf2-knockdown (NK) via siRNA transfection increased the expression of brown adipose tissue (BAT) marker genes including PGC-1α, Dio2 and PRDM16 and lowered the gene and protein expression of white adipose tissue (WAT) marker genes for instance BMP4, Resistin and Rb1 in adipocytes; NK also altered the protein expression of longevity-related genes, such as Sirt1 and AMPKα and increased UCP1 and Cycs, which are involved in mitochondrial generation. These results support the potential of Nrf2 as a possible therapeutic target for delaying aging through the transformation of adipose-phenotype and the effect of longevity factors.
Cost-effectiveness comparison of dalpiciclib and abemaciclib Combined with an aromatase inhibitor as first-line treatment for HR+/ HER2− advanced breast cancer
Authors: Hong Juan , Chen Tujia , Meng Jun , Xia Zhengzheng
Published: October 2023

Background
Dalpiciclib and abemaciclib, both CDK4/6 inhibitors, have been approved by the China National Medical Products Administration for the first-line treatment of postmenopausal women with hormone receptor-positive (HR+) and human epidermal growth factor receptor-2 negative (HER2−) advanced breast cancer (ABC). As the first domestically developed CDK4/6 inhibitor in China, there has been no previous economic evaluation of dalpiciclib. This study aimed to assess the cost-effectiveness of dalpiciclib compared to abemaciclib when used in combination with letrozole for the first-line treatment of HR+/HER2 − ABC from the perspective of healthcare payers in China.
Methods
A Markov model with three health states was constructed to evaluate the health and economic outcomes of first-line treatment with dalpiciclib plus letrozole and abemaciclib plus letrozole for HR+/HER2 − ABC. The efficacy data was obtained from the MONARCH3 and DAWNA-2 trials, while utility data was derived from published reports. Quality-adjusted life-years (QALYs) and incremental cost-effectiveness ratios (ICERs) were calculated. Sensitivity analyses were performed to explore variations in the model results.
Results
Compared to abemaciclib plus letrozole, dalpiciclib plus letrozole resulted in 5.13 additional QALYs, with an ICER of $27,305/QALY. At a willingness-to-pay (WTP) threshold of the gross domestic product (GDP) per capita in China for 2022 ($38,223/QALY), the probability of dalpiciclib plus letrozole being cost-effective was 75%. Sensitivity analysis results were consistent with those of the base-case analysis.
Conclusions
From the perspective of Chinese healthcare payers, the combination of dalpiciclib and letrozole appears to be a more cost-effective strategy when compared to abemaciclib plus letrozole for the first-line treatment of patients with HR+/HER2 − ABC in China.
Internally cross-linked wrinkled fibrous silica nanocomposite by bipyridinum dichloride bridge: an efficient catalyst in the synthesis of α,β-unsaturated diketones
Authors: Nasseri Seham , Kiasat Ali Reza
Published: October 2023

In this research, we designed a novel internally cross-linked wrinkled fibrous organo-silica nanocomposite containing bivalent organic cationic bridges in the framework. For this gold, bivalent organosilane bridging agent, Si(OEt)3-BiPy+22Cl--Si(OEt)3 was easily prepared through nucleophilic substitution reaction of (3-chloropropyl) triethoxysilane and bipyridine. In the next step, silanated bivalent cationic bipyridinium dichloride bridge was introduced into the pore walls of dendritic fibrous nanostructured silica through a sol−gel process under open-vessel reflux conditions. The obtained heterogeneous hybrid nanocomposite, KCC-1-Bipy+22Cl-, was characterized by FT-IR, EDX, TGA, and FE-SEM. The rationale was that such wrinkled fibrous, due to its abundant pores and slits, would acts as nanoreactor and would be an excellent catalyst in organic transformation due to the presence of quaternary ammonium units into the pore walls. Owing to the fact that the α-β-unsaturated carbonyl compounds can further be used in the synthesis of valuable intermediates, the catalytic ability of the nanocomposite was tested in the C=C bond formation reaction via Knoevenagel condensation of aldehyde and active methylene compounds under solvent free conditions. In addition to convenience, utilization of the catalyst with high catalytic activity and good reusability, makes this method as an interesting option for facile and efficient synthesis of α,β-unsaturated diketones derivatives.
Identification and Validation of a Prognostic Signature of m 5 C-Related Genes for Esophageal Cancer
Authors: Huang Zhengrong , Wang Liyan , Lin Qing , Shen Wenbin , Zhang Yiping , Lin Zhizhong , Chen Yuanmei , Shen Yongshi , Chen Juhui , Chen Junqiang , Dong Jingjing , Xu Yuanji
Published: October 2023

Background
Esophageal cancer (ESCA) is a prevalent form of cancer with a grim prognosis. It has been reported that 5-methylcytosine (m5C) regulators are closely linked to carcinogenesis and distant metastasis. However, the role of m5C regulator in ESCA is still elusive. The aim of this study was to investigate the connections between m5C regulators and the initiation and progression of ESCA, with a particular focus on prognosis.
Methods
Gene expression profile data from TCGA database, including 11 normal and 142 tumor tissues, were obtained and divided into two ESCA subtypes according to the m5C regulators expression. Differentially expressed genes (DEGs) of two ESCA subtypes, normal and tumor tissues from TCGA, and normal and tumor tissues from validation datasets were analyzed. Inter-DEGs were filtered from the overlap of three sets of DEGs which named inter-DEGs. Functional analysis, immune infiltration analysis, drug sensitivity analysis, prognosis model was carried out to investigate the biological function and potential role of m5C regulators in ESCA. The expression of PLA2G2F, HHIP, TNXB, and STK31 in ESCA and adjacent esophageal tissues was detected by RT-qPCR.
Results
The expression of m5C regulators, namely TRDMT1, NSUN2, NSUN4, NSUN6, DNMT1, ALYREF, and YBX1, were upregulated in ESCA subtype 2 group. Correlation analysis demonstrated that m5C regulators positively correlated with E2F targets, G2M checkpoint, MYC targets V1, while negatively correlated with TNF-α signaling via NF-kB, and Notch signaling pathway. Additionally, the immune infiltration analysis indicated that m5C regulators was positively correlated with Macrophages M0, and negatively correlated with T cells CD8 infiltration. 4 independent prognostic genes, including PLA2G2F, HHIP, TNXB, and STK31, were selected to construct prognostic model and exhibited good function in predicting the prognosis of ESCA patients. RT-qPCR was used to validate the gene expression that the PLA2G2 had higher expression in ESCA tissues compared to adjacent tissues, while the expression of STK31, HHIP, and TNXB showed down regulation in ESCA tissues.
Conclusions
This study explored the comprehensive feature of 2 subtypes of m5C regulators in ESCA patients, which may improve understanding of m5C regulation in the tumor biology of ESCA.
Optimisation-based Design of Market-based Policy Instruments for Accelerating the Uptake of CCUS for Global Refinery Decarbonisation
Authors: Ofori-Atta Christabel , Oluleye Gbemi
Published: October 2023

CCUS is broadly heralded as a substantive opportunity to deeply offset emissions from the oil refining industry. However, high cost of capture remains a major barrier to adoption. Although developments of new technologies and infrastructure are still ongoing and poised to appreciably improve the economics for CCUS in the future, widescale deployment is still critically dependent on policy interventions. This work develops a novel optimisation-based multi-market potential assessment model to quantify the impact of combined policies in increasing market uptake and reducing mitigation cost of new CCUS technologies by 2030 among refineries considered to be operating under CCUS clusters with a shared transport and storage network business model. The methodology is applied to 512 refineries in 86 countries grouped under 8 different regions worldwide. Results show that sufficient demand among refineries can be generated from policies combined globally to trigger further cost reductions to a target cost of capture of ≤ US$40 /tCO2. Overall, 33% maximum cost savings is possible at a worldwide cost of US$ 46.3 billion shared between governments and the industry largely in the form of unified carbon taxes and grant support. Moreover, refineries in Asia, North America and Europe are more likely to lead CCUS cost savings as high as 22% due to their huge market potential and policy mix support from capital funding, tax credits for EOR and storage, and emissions allowances, as opposed to potential in Africa and Oceania. Ultimately, there is need for coordinated global efforts for policy measures for CCUS uptake.
Utilization of SGLT-2 Inhibitors in Congestive Heart Failure Management
Authors: Daniels Anna , Bank Deborah
Published: October 2023

Congestive heart failure (CHF) is a progressive condition where the heart cannot pump blood well enough to keep up with volume demand, which results in decreased oxygen perfusion throughout the periphery and vital body organs. This condition affects over six million Americans and is projected to increase by over 46% by the year 2030. By incorporating evidence from research conducted over the past ten years, several studies demonstrate the benefits of sodium-glucose co-transporter (SGLT-2) inhibitors in managing CHF patients. The glucose-lowering medication works to relieve fluid overload by excreting excess glucose and sodium while also increasing vasodilation and reducing cardiac preload. SGLT-2 inhibitors also have an anti-inflammatory effect that decreases epicardial adipose deposition, which relieves oxidative stress on the heart. In addition to the mainstay of medical management for CHF patients, SGLT-2 inhibitors have reduced exacerbations that are often life-threatening and improved overall quality of life by reducing morbidity and mortality.
EMERGENCY MEDICINE IN KINGDOM OF SAUDI ARABIA: AN ERA OF DEVELOPMENT AND A BRIGHT THERAPY FOR THE FUTURE. AN APPRAISAL
Authors:   Ministry Of Health, Bader AljunobGeneral Hospital, Najran, Kingdom Of Saudi Arabia., Saleh Al Saad Abdulkhaliq , Ali Alwalah Saleh ,   Ministry Of Health, Bader AljunobGeneral Hospital, Najran, Kingdom Of Saudi Arabia., Thawran Al Saad Thaib ,   Ministry Of Health, Bader AljunobGeneral Hospital, Najran, Najran, Kingdom Of Saudi Arabia., Ali Alqanass Yahya ,   Ministry Of Health, Bader AljunobGeneral Hospital, Najran, Najran, Kingdom Of Saudi Arabia., Mohammed Ali Alqahtani Ali ,   Ministry Of Health, Bader AljunobGeneral Hospital, Najran, Najran, Kingdom Of Saudi Arabia., Mohammed Al Saad Hamad ,   Ministry Of Health, Bader AljunobGeneral Hospital, Najran, Najran, Kingdom Of Saudi Arabia.
Published: October 2023

Objectives: To identify the intergender variation of on-scenetime (OST) for highly urgent emergency cases conveyed by emergency medical services (EMS) in Saudi Arabia and to assess other predictors of OST and hypothesis for possible factors delaying OST. Design: A retrospective population-based registry study. Setting: Riyadh Province is the largest provincein terms of population and the second in terms ofgeographical area. Participants: All highly urgent transported patients from the scene to emergency departments, be they medical emergencies or trauma emergencies during 2018. Outcome Measure:OST difference between men and women transported by EMS. Although emergency medical services (EMS) and pre-hospital care have existed in the Kingdom of Saudi Arabia (KSA) since 1934, emergency medicine (EM) is a relatively new medical field in the country that was not formally recognized as a medical specialty until 2001. In 2005, the Saudi Board of Emergency Medicine formed to develop, implement, and evaluate a standardized curriculum for EM residents. Since then, EM and the pre-hospital system in the KSA has evolved and grown. This article provides an overview of emergency medicine in Saudi Arabia and the progress it has made in the pre-hospital system, healthcare delivery system, and emergency medicine training. Finally, we will discuss the challenges and opportunities faced as this specialty continues to develop.
Ethical Leadership and Employee’s Performance in Lagos State Government-Office of the Auditor General
Authors: Elegunde Ayobami , Omolara Olufunke Tayo , Abimbola Motunrayo
Published: October 2023

Ethical leadership is leadership that is directed by respect for ethical beliefs and values and for the dignity and rights of others. This study examined the effects of ethical leadership on employee performance in Lagos State Government-Office of Auditor General. The objectives of the study were to: examine the effect of ethical leadership on employee effectiveness in Lagos State Government-Office of the Auditor General; investigate the effect of ethical leadership on employee job satisfaction in Lagos State Government-Office of the Auditor General and evaluate the influence of ethical leadership on employee productivity in Lagos State Government-Office of the Auditor General. The study adopted a descriptive survey research design on a population of 381 of Lagos State Government-Office of Auditor General. Purposive sampling technique was employed in administering the research instrument. The research instrument employed was a questionnaire. Data were gathered from primary source. The research instrument employed was a self-constructed 5-point Likert scale questionnaire. The research instrument was validated through content validity and a Cronbach alpha reliability test of 0.875, 0.895 and 0.823 indexes were conducted. The results of the study revealed that ethical leadership has a significant influence on employee effectiveness, job satisfaction and productivity. Thus, the study recommended that the leadership of the commission should adopt equal treatment of its staff to help improve the quality and increase employees’ sense of commitment towards their job.
Deep Transfer Learning for Sign Language Image Classification: A Bisindo Dataset Study
Authors: Rachmawati Ika Dyah Agustia , Yunanda Rezki , Hidayat Muhammad Fadlan , Wicaksono Pandu
Published: October 2023

This study aims to identify and categorize the BISINDO sign language dataset, primarily consisting of image data. Deep learning techniques are used, with three pre-trained models: ResNet50 for training, MobileNetV4 for validation, and InceptionV3 for testing. The primary objective is to evaluate and compare the performance of each model based on the loss function derived during training. The training success rate provides a rough idea of the ResNet50 model's understanding of the BISINDO dataset, while MobileNetV4 measures validation loss to understand the model's generalization abilities. The InceptionV3-evaluated test loss serves as the ultimate litmus test for the model's performance, evaluating its ability to classify unobserved sign language images. The results of these exhaustive experiments will determine the most effective model and achieve the highest performance in sign language recognition using the BISINDO dataset.
Structural Time Series Model using Hamiltonian Monte Carlo for Rice Price
Authors: Ni'mah Rifdatun
Published: October 2023

Although forecasts of future events are simply uncertain, predicting is one of the most important aspects of future planning. Accurate rice price predictions tend to be helpful for wholesalers, producers, and farmers to develop plans and strategies to reduce the risks that can be faced. Structural time series models are the most plausible alternative for long-term forecasting. This paper proposes an alternate method for modeling average rice prices using structural time series along with Bayesian parameter inference via Hamiltonian Monte Carlo (HMC). The model has been built using the monthly average wholesale rice price from January 2010 to December 2019. For working out both structural time series and HMC, the TensorFlow Probability Library was used. Linear trend, seasonal, and autoregressive components were combined as an additive model to the structural time model. The proposed Hamiltonian parameter produces an optimal acceptance rate. Their trace plot was used to diagnose the convergence of their chain. One of the predictive accuracy of models was assessed using the mean absolute percent error (MAPE). Through both single and multiple chain iterations, the prediction accuracy of a year-ahead is highly accurate, with MAPE less than 2%. Long-term iteration draws during Hamiltonian Monte Carlo should be considered when attempting to achieve more convergence.
Government Recommendations for the Effective Implementation of QuickCommerce Policy to Transform the E-Commerce Sector
Authors: Younus Muhammad , Sulaksono Tunjung , Suranto Suranto
Published: October 2023

This paper aims to determine the guideline regarding the Initiative of the Government to transform the E-commerce industry of the country and take it to a new level of QuickCommerce. The Researchers who are working on the research in this field of work are using ‘Qualitative Research.’ This research material was taken from social media, Online Media, Websites, and Articles, and then it is displayed in descriptive format. This paper indicates that making this guideline will ensure the improvement needed in the E-commerce Market and make it ready for the successful implementation of QuickCommerce in the country. Several steps need to be followed to create and successfully implement QuickCommerce—first, the analysis and determining the significant challenges are present currently, which is pushing back the smooth implementation. Second, the selection of the way forward for the implementation of it and deciding the critical indicators required for it. Finally, then proposing the solution based on the analysis. This study is limited to the extent to which the problem is clearly defined, then suggests the solution with its working flow, and lastly, what advantage it will provide to solve the problem that the current E-commerce market is facing.
Metabolic syndrome: prospects for the use of angiopoetin-like proteins type 3 and 4 for the diagnosis of metabolic disorders
Authors: Aleksandrov V. A.
Published: October 2023

Metabolic syndrome (MetS) is a major global public health problem. Abdominal obesity, arterial hypertension, disorders of carbohydrate metabolism and dyslipidemia are widely recognized and the most important components of MetS. The angiopoietin-like system, which includes eight types of angiopoietin-like proteins (ANGPTLs), is recognized as an important regulator of adipose tissue function. Angiopoietin-like proteins types 3 and 4 (ANGPTL3/4) are the most studied in terms of their influence on cardiovascular risks and are of interest in terms of their function in conditions associated with MetS. This review focuses on considering the role of ANGPTL3/4 in the development of each condition from the constellation of abnormalities that characterize MetS. The key role of ANGPTL3/4 as modulators of the interaction between the liver and adipose tissue is demonstrated based on the analysis performed on the current data in the PubMed information. Their involvement in lipid homeostasis, glucose, type 2 diabetes, hypertension, non-alcoholic fatty liver disease and sleep apnea, i.e. in the maximum spectrum of conditions determining MetS, has been considered in detail. It’s been proven that ANGPTL3/4 can act as indepen dent predictors of MetS, demonstrating a potential role as prognostic biomarkers of metabolic disorders. Understanding the peculiarities of ANGPTLs functioning can offer both new diagnostic and therapeutic approaches to diseases with MetS. Close targeting of ANGPTL3/4 and the development of innovative therapies involving blockers of their action have the potential to have a significant impact on the effectiveness of treatment of metabolic disorders in humans in future.
Features of treatment of transthyretin amyloid cardiomyopathy: clinical case
Authors: Nasonova S. N. , Chaikovskaia O. Ya. , Shoshina A. A. , Osmolovskaya Yu. F. , Zhirov I. V. , Tereshchenko S. N.
Published: October 2023

For several years, there has been a significant increase in the number of patients diagnosed with cardiac amyloidosis or amyloid cardiomyopathy (AC). The reason is the growing concern of specialists about amyloidosis and the increased accuracy of the instrumental methods of examination of patients of cardiological profile. Nowadays, more than 30 types of amyloidosis are known, however, the two main types are most commonly associated with cardiac involvement: amyloidosis of light chains (AL) and transthyretin amyloidosis (ATTR). Regardless of the underlying pathogenesis of amyloid production, cardiac involvement is the main cause of mortality in systemic amyloidosis. In addition to difficulties in early diagnosis, there are difficulties with further management of the disease. With the appearance of specific treatment, different depending on the type of amyloidosis, the problem of symptomatic therapy in these patients has become acute. Heart failure (HF) signs are usually prevalent in cardiac signs. Besides, patients with AC often have various arrhythmias and heart conduction disorders. However, the selection of heart failure therapy in patients with AC is complicated by the development of restrictive hemodynamic phenotype and concomitant autonomic dysfunction, making it impossible to manage standard heart failure therapy. The article presents a clinical case of a patient with a hereditary type of transthyretin amyloidosis with the cardiac involvement, whose main clinical manifestations were heart failure, cardiac rhythm and conductions disorders. This case demonstrates the importance of comprehensive and personalized approach in the management of ATTR-AC, the features of pathophysiology which require special approaches even to management of symptomatic therapy.
Efficacy of sacubitril / valsartan in the treatment of chronic heart failure: an updated review
Authors: Leonova M. V.
Published: October 2023

Chronic heart failure (CHF) is currently a common disease and the search for new approaches to the treatment of various forms of CHF remains relevant. Sacubitril/valsartan is a member of a new class of angiotensin-neprilysin receptor inhibitors (ARNIs) that act on key neurohormonal mechanisms, including the RAAS and natriuretic peptides. Simultaneous inhibition of RAAS and neprilysin provides more effective neurohormonal modulation, preventing clinical deterioration in patients with CHF. New mechanisms of action of sacubitril/valsartan associated with the inhibition of several targets involved in cardiac hypertrophy, fibrosis, cardiac remodeling and apoptosis have been disclosed. Sacubitril/valsartan is recommended for CHF with low ejection fraction (EF) in addition to traditional therapy with ACE inhibitors, mineralocorticoid receptor antagonists, beta-blockers, and also has an independent effect. A number of studies have shown the effect of sacubitril/valsartan on heart remodeling, a decrease in the level of the NT-proBNP biomarker and an improvement in EF, and according to the PARADIGM-HF study, the drug significantly reduced the risk of cardiovascular mortality by 20% and hospitalizations for CHF by 21%, which found confirmation in three meta-analyses. The use of sacubitril/valsartan in CHF with preserved and intermediate EF showed a beneficial therapeutic effect and a decrease in the level of biomarkers, as well as a significant decrease in the frequency of hospitalizations due to CHF by 15–22%, but without a significant advantage in terms of the effect on mortality, which supported by several meta-analyses of studies. A number of large meta-analyses of studies of sacubitril/valsartan in CHF have shown reverse cardiac remodeling and a reduced risk of atrial fibrillation. Thus, the accumulated data substantiate and expand the possibilities of using sacu-bitril/valsartan in CHF.
Study of the role of various diagnostic methods in patients with benign and neoplastic cervical diseases
Authors: Karakhalis L. Yu. , Petrenko V. S. , Petrenko S. I.
Published: October 2023

Introduction. Cervical intraepithelial neoplasias that have been recognized as a precursor of squamous cell carcinoma are subject to active detection for the purpose of eradication. Human papillomavirus (HPV) exposure of women is the major risk factor for carcinogenesis, which is a necessary part for the formation of a pre-tumour and malignant phenotype. Cervical intraepithelial neoplasias that precede the development of squamous cell carcinoma should be actively detected and treated early. The identification of patients with HPV is an important part of subsequent therapies. Inosine pranobex is used as one of the components of the treatment of HPV-associated diseases.

Aim. To study the role of various diagnostic methods in patients with benign and neoplastic cervical processes.

Materials and methods. The study included 311 women who were 21–64 years old. Colposcopy, cytological examination, HPV testing, preliminary biopsy, cervical excise with histological evaluation of tissue sampling were carried out.

Results. HPV 16 was more often detected in a malignant tumour and CIN 3; HPV type 31 and 33 were more often detected in CIN 2 and CIN 3; HPV type 18 was detected in almost all patient with CIN, and malignant and benign neoplastic disorders in preliminary biopsy, that was not typical of results of the excision. In excision CIN 1 were confirmed in 17.07%, CIN 2 in 31.88%, CIN 3 in 66.67%. Preliminary results of benign process in 6.67% turned out to be CIN 1, and in 6.67% – CIN 2, that confirms the need for a comprehensive evaluation. Studies of prevalence of various types of HPV showed that the established sequence of recommended tests, which consists of extended colposcopy, cytology and identification of HPV types, if necessary, does not always correspond to the biopsy results and histological findings on cervical excision specimens. According to our sources, the final result can be determined after excision procedure of cervical tissue and histological examination of the tissue obtained.

Conclusion. No strong correlations between examination methods and cervical pathology have been revealed. The final diagnosis is made after cervical biopsy. High prevalence of different types of HPV raises the question of need for complex therapy with inclusion the inosine pranobex.
Dienogest therapy: a window of opportunity for endometriosis
Authors: Yakushevskaya O. V. , Iurova M. V. , Mezhevitinova E. A.
Published: October 2023

Endometriosis is a disease characterized by a benign growth of tissue identical to the endometrium outside the uterine cavity with an accompanying inflammatory process. The exact prevalence of external genital endometriosis (EGE) is unknown. According to some data, the prevalence varies from 2% to 10% among the general female population and up to 50% among women with established infertility. Currently, there is no single theory that could fully explain the causes and mechanisms of the development of the disease. The etiopathogenesis of endometriosis is widely discussed and remains uncertain. The main clinical markers of the disease are chronic pelvic pain, dysmenorrhea, dyspareunia, and infertility. The progressive and recurrent course of EGE with a significant deterioration in the quality of life of women is the main motivation for the scientific community in the search for radical therapeutic methods. The main goal of therapy is to reduce pain, correct reproductive dysfunction, prevent / slow down the occurrence of such long-term consequences associated with endometriosis, such as fibrosis, adhesions and malignant transformation. Available advanced technologies aimed at establishing and studying the pathophysiology of endometriosis have made it possible to optimize therapeutic strategies. However, many controversial issues still arise in routine clinical practice. This article will provide an overview of the general basic concept of disease pathogenesis and highlight the role of hormonal treatment (dienogest) in women with endometriosis.
Menopausal transition. Is it possible to delay the prescription of menopausal hormone therapy?
Authors: Khashukoeva A. Z. , Markova E. A. , Burdenko M. V. , Nosova L. A. , Solovyova A. M. , Lukyanova E. A.
Published: October 2023

After the end of the reproductive period, women spend a third of their lives in menopause. During this period, they experience a range of predictable symptoms and conditions associated with changing levels of sex hormones and aging of the body. The menopausal transition precedes menopause by several years and is usually characterized by irregular menstrual cycles, hot flashes and night sweats. After menopause, genitourinary symptoms predominate, including vulvovaginal atrophy and dryness and complaints associated with urinary disturbances: increased urinary frequency, urgency, and nocturia. Menopausal hormone therapy is effective for vasomotor and genitourinary symptoms, but it is associated with the development of cardiovascular risks, cognitive impairment, depression, and a number of side effects. An alternative in the therapy of menopausal symptoms can be the prescription of biologically active supplement Happyclim®. The complex composition of the drug effectively fills the lack of its own estrogen in the female body. The preparation Happyclim® contains phytoestrogens (soy isoflavones, flavonoids) and auxiliary components (magnesium and B vitamins, vitamin C, extract of medicinal melissa), which with high efficiency affect the woman’s body during menopausal transition, alleviating the symptoms of menopause and improving the quality of life. This article presents a cross-section of the literature on the use of phytoestrogens and the dietary supplement Happyclim® during the perimenopausal transition to delay the administration of menopausal hormone therapy.
Hemopericardium after coronary artery stenting: clinical observations and literature review
Authors: Semigolovskii N. Yu. , Simutis I. S. , Mazurenko S. O. , Nikolskaya E. M. , Mazurenko M. O.
Published: October 2023

Currently, at least 5,000,000 patients with coronary artery disease undergo percutaneous coronary interventions with stent implantation every year in the world, and more than 200,000 in Russia. Dissection and perforation of the coronary artery are quite rare, but they are very dangerous complications leading to the development of hemopericardium with cardiac tamponade, cardiogenic shock, myocardial infarction, various arrhythmias and death. The frequency of cardiac tamponade in interventional cardiology, according to various authors, ranges from 0.1 to 3.0% of all interventions. The frequency of deaths cited in the literature also varies greatly (0–20–40%). At the same time, there are no special registers that accumulate data on coronary artery perforations in concrete countries and in the world as a whole. Unfortunately, today, there is still no clear algorithm for identifying high-risk patients, the necessary timing of their intensive follow-up is not clear, and the criteria for choosing between conservative, angiosurgical and operative treatment tactics are not defined. In addition to a literary review of recent sources on this topic, the article presents 3 clinical cases of hemopericardium development in elderly patients at different times after percutaneous interventions, with different symptoms and with different outcomes. The observations illustrate the variability of symptoms, the complexity of diagnosis and treatment, and also touch upon the issues of a multidisciplinary approach with the participation of specialists of different profiles (X-ray angiosurgeons, cardiac surgeons, intensive care specialists, cardiologists and doctors of functional diagnostics).
UNVEILING THE NUTRITIONAL POTENTIAL OF STAR FRUIT (Averrhoa carambola): IN VITRO BIOACCESSIBILITY STUDY
Authors: Kamioka Tatiana , Xavier Alexsandra , Coelho Alana , Nogueira Angerson
Published: October 2023

A method was developed for quantifying the concentrations of Ca, Fe, Mg, and Zn in star fruit. An in vitro assay was used to evaluate the bioaccessibility of these elements after a simulated gastrointestinal digestion. The results showed that the total elemental concentration in star fruit were 78-186.2 mg kg-1 for Ca, 92.1-148.1 mg kg-1 for Mg, below the limit of detection for Fe and Zn. The bioaccessibility of Ca and Mg was 40 and 58%, respectively. These bioaccessibility percentages were attributed to the presence of an antinutrient in star fruit that promotes precipitation of insoluble compounds during the in vitro assay. Based on the data from gastrointestinal digestion assay, it is possible to conclude that star fruit intake can supply 1.6-2.04% and 11.2-19.6% of the recommended dietary allowance (RDA) of Ca and Mg, respectively.
FACILE FABRICATION OF ANILINE SENSOR BY USING COMMERCIAL CALCIUM SILICATE HYDRATE NANOSHEETS AS SENSING MATERIAL
Authors: Wang Luyu , Song Jia , Yu Chunyang
Published: October 2023

Various aniline sensing materials have excellent properties based on quartz crystal microbalance (QCM) transducer, but their synthesis processes are complex. Herein, commercial calcium silicate hydrate nanosheets (CSH-S) was utilized for facile fabrication of aniline sensor based on QCM platform. This sensor was capable of detecting 0.1 ppm aniline, and the response time (14 s) and recovery time (16 s) were short. Besides, the devices could restore sensitivity after 30 days, demonstrating excellent stability. In addition, variable temperature experiment combined with simulation calculation methods were carried out to study the adsorption of aniline on CSH-S surfaces, then the sensing mechanism was revealed. This work opens up a rapid and convenient method for detecting gaseous aniline.
Voltaic Cell Learning Design Using the RADEC (Read, Answer, Discuss, Explain, and Create) Model Oriented toward the Pancasila Student Profile
Authors: Sutantri Nursida , Sopandi Wahyu , Wahyu Wawan , Latip Abdul
Published: October 2023

This study aimed to describe the Voltaic Cell learning design using the RADEC (Read, Answer, Discuss, Explain, and Create) learning model based on the Pancasila Student Profile. The approach employed in this research was descriptive qualitative. The research instrument was a validation sheet in the form of a questionnaire administered to five validators, consisting of two Expert Lecturers in Chemistry Education at Universitas Pendidikan Indonesia and three Chemistry teachers who taught at Sekolah Penggerak in Bandung City, employing the Merdeka Curriculum. The data processing results demonstrated an average percentage of 96.7% for the alignment of the lesson plan across four aspects: Formulation of Competency Achievement Indicators and Learning Objectives, Presented Content, Language Usage, and Time Allocation. The findings also indicated a connection between the voltaic cell learning activities using the RADEC learning model and the manifestation of the Pancasila Student Profiles, including Faith in God Almighty, Noble Characters, Global Diversity, Mutual Cooperation, Independence, Critical Reasoning, and Creativity, producing an average percentage of 95.4% classified into the excellent category. Hence, this study signified that the voltaic cell learning design using the RADEC model could cultivate the Pancasila Student Profile.
A Study on The Reality of e-Learning for Chemistry Students During The COVID-19 Pandemic
Authors: Al-Dahhan Wedad H , Zainulabdeen Khalid , Yousif Emad , Al-Amiery Ahmed Abdulameir , Bufaroosha Muna
Published: October 2023

In a survey conducted by the Department of Chemistry on the reality of e-learning, which became widespread in most international universities during the COVID-19 pandemic in 2020, up to 50 students participated to express their thoughts and confirm observations. This survey was crucial in determining the importance of e-learning for the continuity of education and its potential drawbacks. The students’ opinions were collected using specific questions designed for a questionnaire. The survey's key findings can be summarized as follows: Both students and teaching staff played pivotal roles in the success of e-learning. Additionally, the availability of logistical tools and infrastructure that facilitated communication between students and lecturers proved vital to the effectiveness of online learning.