bluuebunny/crossref_metadata_2025 huggingface dataset:
MBLDP-R: A Multiple Biomolecules Based Rapid Life Detection Protocol Embedded in a Rover Scientific Subsystem for Soil Sample Analysis
Authors: Zaman Akib , Ashraf Fardeen , Khan Haseena , Noshin Faria , Samir Oiliullah , Rayhan Asif Mahmud , Nazifa Sadia Nur , Chowdhury Hafsah Mahzabin , Rahman Mahbubur
Published: January 2022

A rapid multiple biomolecules based life detection protocol (MBLDP-R) from soil samples is proposed to embed in a scientific rover subsystem targeted for planetary analysis missions complying the guidelines of Science Mission of University Rover Challenge 2021 (URC 2021). The proposed protocol selects suitable biomolecules from a preliminary list through a requirement analysis driven filtration process emphasizing two factors: a) rules of URC 2021 and b) compatibility of the biomolecule test equipment to be embedded in a rover subsystem. To sort out the best test methods for finally selected biomolecules, a weighted qualitative test scoring methodology is applied. A rover subsystem that implements the protocol was built to perform onboard sample analysis. Evaluation results show that: 1) ) the proposed MBLDP-R protocol could effectively predict the classes with an average f1-score of 98.65% (macro) and 90.00% (micro) and the area under the Receiver Operating Characteristics (AUC-ROC) curve shows the sample categories to be correctly predicted 92% of the time (97% Extant, 88% Extinct and 92 % in case of NPL) and 2) the protocol is time-efficient with an average completion time of 17.60 minutes that demonstrates the rapid nature of the protocol to detect bio signatures in soil samples.
Machine Learning-Based Classifiers To Predict Metastasis in Colorectal Cancer Patients
Authors: Borumandnia Nasrin , Akbari Abolfazl , Gramifar Mohammad , Talebi Atefeh , Pourhoseingholi Mohamad Amin , Azizpour Mazaher , Tabaeian Seidamir Pasha , Sedaghat Meghdad
Published: January 2022

Background: The increasing prevalence of colorectal cancer (CRC) in the past three decades in Iran has made it as a key public health burden. The goal of the study was to predict the metastasis in CRC patients using machine learning approach. Methods: This study is focused on 1127 CRC patients, who underwent proper treatments in tertiary Taleghani Hospital. The machine learning approach including Naive Bayes (NB), Random Forest (RF), Support Vector Machine (SVM), Neural Network (NN), Regression Tree (RT) and Logistic Regression (LR) were used for the prediction of metastasis in CRC. Receiver operating characteristic (ROC) curve, sensitivity, specificity and AUC were carried out to evaluate the performance of the approaches Results: Out of 1127 patients, 183(16%) experienced metastasis. In prediction of metastasis, the NN and RF had the most sensitivity. Also the specificity of NN and DT were greater in comparison to other methods. The NN had the highest AUC (0.99%), topmost sensitivity (98.5%) and accuracy (99.6%).Conclusion: Both tumor stage and size of tumor were regarded as indispensable variables in RF model, whereas the NN generally outperformed other ML-based approaches.
Novel Mechanism of Lowering Blood Pressure by Electroacupuncture:MicroRNA9/P2RX7
Authors: Yue Bing-Nan , Sun Jiao , Zhou Zi-Xian , Li Xiao-Lu , Liu Xin , Liu Qing-Guo
Published: January 2022

Backgroud Our previous studies have reported electroacupuncture(EA) can regulate the relevant indicators of essential hypertension(EH) such as angiotensinII(ANGII),ANG(1-7) and inflammatory cytokines.But the mechanism of EA remains unclear. The goal of this study was to verify P2RX7 as one direct target of miRNA-9,which triggers the release of ANGII and PICs(TNF-α, IL-6)in the PVN.The system of miRNA-9/P2RX7 might be a novel mechanism of lowering blood pressure.Method Spontaneously Hypertensive Rats(SHRs) were selected as an animal model of hypertension while WKY rats were considered as a blank group.Bipolar cannula implantation were used to inject inhibitors in the paraventricular nucleus(PVN).We measured the systolic blood pressure(SBP) of animals on different days of acupuncture therapy(0,3,7,10,14).We examined the level of microRNA-9 by RealTime-PCR.RT-PCR and western blot was utilized to detect the mRNA and protein levels of P2RX7 in each group.The activation of microglias was detected by immunohistochemistry staining with antibody Iba1.ANGII,IL-6 and TNF-α were detected by ELISA in the PVN and plasma.Results Our results showed that EA reduces systolic blood pressure of SHRs.EA increased the level of miR-9 notably comparing to sham groups.In addition,SHRs in the EA group had significantly lower P2RX7 protein and mRNA levels than those in the sham group,while miR9-inhibitor downregulated the expression of P2RX7 in the PVN comparing to EA groups. Immunohistochemistry staining showed that EA treatment and P2RX7 inhibitor significantly inhibited the activation of microglia.We also found that the combination of P2RX7-inhibitor and EA had a better anti-inflammatory effect and better inhibition of ANGII,while using miR9-inhibitor prevented the effect.Conclusion Taken together, our data demonstrates that P2RX7 is a direct downstream receptor of miRNA-9.Regulating system, miRNA-9/P2XR7, decreases the release of ANGII and alleviates inflammation in the PVN and plasma of SHRs,which indicates a novel microRNA-mediated mechanism of EA.Furthermore, the present investigation provides the combination treatment of P2RX7-inhibitor and EA as a better intervention in the area of anti-inflammatory.
In Vitro Anticancer and Antibacterial Activity of Green Synthesized ZnO NPs Using Clitorea Ternatea Flower Extract: Inhibits MCF-7 Cell Proliferation Via Intrinsic Apoptotic Pathway
Authors: Alahmdi Mohammed Issa , Syed Khasim , Vanaraj Sekar , Panneerselvam Chellasamy , Mahmoud Mahmoud A Abdelaziz , Mukhtar Sayeed , Alsharif Meshari A , Zidan Nahla S , Abo-Dya Nader Elmaghwry , Aldosari Obaid F
Published: January 2022

Herein, we report a strategy to synthesize zinc oxide nanoparticles (ZnO NPs) from Clitorea ternatea flower extract through green synthesis platform. The bioactive components in the C. ternatea flower extract acts as a stabilizing and capping agent, which enables the synthesis of ZnO NPs without the use of chemical reagents. Synthesis of of ZnO NPs through green platform was confirmed by analytical characterization techniques such as UV-Vis spectrophotometry, XRD, FTIR, DLS, Zeta potential, TEM, and EDX methods. The surface morphology and average size of ZnO NPs investigated through TEM and DLS results indicates rod shaped structure with average particle size of 84 nm. Green synthesized ZnO NPs shows excellent antibacterial, antibiofilm, and antioxidant activity which is dose-dependent. These ZnO NPs have cytotoxicity against breast cancer cells (MCF-7). The MTT test revealed a concentration-dependent inhibitory effect on MCF-7 cells, with IC50 being 12.1 g/ml, and their anticancer potential was detected utilizing live and dead cell assays LDH release, Ao/EtBr), DAPI, ROS, and caspase-3 activation assays. Finally, the findings of these results shows that ZnO NPs derived from Clitorea ternatea flower extract are highly potential candidates to treat bacterial infection and human breast cancer.
Spin-1/2 one- and two- particle systems in physical space without eigen-algebra or tensor product
Authors: Andoni Sokol
Published: January 2022

A novel representation of spin 1/2 combines in a single geometric object the standard Pauli spin operator and spin state. Under the spin-position decoupling approximation it consists of the sum of three orthogonal vectors comprising a gauge phase. In the one-spin case the representation: (1) is Hermitian; (2) endowed with handedness; (3) yields all standard results, including the total spin angular momentum; (4) relates basis spins by proper rotations, thus preserving handedness; (5) allows formalizing irreversibility in spin measurement. In the bipartite case: (1) entangled spins have precisely related gauge phases and opposite handedness; (2) maximally entangled spins relate by one of the four improper rotations in 3D: plane-reflections (triplets) and inversion (singlet); (3) the full spin expressions yield the standard total two-spin angular momentum; (4) all standard expected values for bipartite observations follow. Depending on whether spin operations act one – or two – sided, the formalism appears in two complementary forms, the ‘spinor’ or the ‘vector’ form, respectively. The proposed scheme provides a clear geometric picture of spin transformations and correlations in the 3D physical orientation space.
The Possible Protective Effect of Hepatitis B Vaccine against Lymphomas: A Systematic Review
Authors: La Torre Giuseppe , Lia Lorenza , Grima Daniela , Amici Francesca , Manzi Linda , Monaci Alessandro
Published: January 2022

Background:

In the last few years, the possible etiological role of the Hepatitis B virus
(HBV) in the outbreak of extrahepatic pathologies has been studied, including lymphomas. The
World Health Organization (WHO) estimates that around 257 million people live with chronic
HBV infection, and to date, the vaccine is the most effective means of prevention.

Objective:

The aim of this review was to evaluate whether the vaccination against Hepatitis B can
lead to a reduction in lymphoma cases and has a protective role.

Methods:

A literature search was conducted in April 2020 using the databases Scopus, PubMed,
and ISI Web of Science. Search terms included: “Hepatitis B vaccination AND lymphoma.” All
articles evaluating the association between Hepatitis B vaccination and the prevention of lymphoma
were selected. No limits were applied.

Results:

Eight studies were eligible to be included in the review. Data showed that association
between lymphoma and HBV infection is not the same for all types of lymphomas, but it appears
to be more significant for Non-Hodgkin Lymphoma (NHL). The results from all the considered
articles were not unitary. This is because studies were conducted in different countries with different
endemicity of Hepatitis B, different vaccination coverage, treatment of chronic Hepatitis, and
prevention of its complications, as well as the availability of data for researchers. No statistically
significant association was found between HBV vaccination and the development of lymphomas.

Conclusion:

Although the literature is still largely lacking regarding the protective effect of anti-
HBV vaccination on lymphoma subtypes, the association between HBV infection and lymphoma
has been confirmed in several studies. Vaccination programs eliminate the risk of HBV infection
and prevent liver disease but can also indirectly reduce the risk of lymphomas.
Targeting Options of Tumor-Associated Macrophages (TAM) Activity in
Gliomas
Authors: Anagnostakis Filippos , Piperi Christina
Published: January 2022

Tumor-associated macrophages (TAMs), the most plastic cells of the hematopoietic system,
exhibit increased tumor-infiltrating properties and functional heterogeneity depending on tumor
type and associated microenvironment. TAMs constitute a major cell type of cancer-related inflammation,
commonly enhancing tumor growth. They are profoundly involved in glioma pathogenesis,
contributing to many cancer hallmarks such as angiogenesis, survival, metastasis, and immunosuppression.
Efficient targeting of TAMs presents a promising approach to tackle glioma progression.
Several targeting options involve chemokine signaling axes inhibitors and antibodies, antiangiogenic
factors, immunomodulatory molecules, surface immunoglobulins blockers, receptor and
transcription factor inhibitors, as well as microRNAs (miRNAs), administered either as standalone
or in combination with other conventional therapies. Herein, we provide a critical overview of current
therapeutic approaches targeting TAMs in gliomas with the promising outcome.
Magnesium Sulphate-Catalyzed Green and Efficient Synthesis of Some
New Derivatives of 1-Amido Alkyl Naphthols under Solvent-Free Conditions
Authors: Chavhan Namdeo M. , Bhakare Sagar D. , Muthe Rohit C. , Hande Sayaji Y. , Gandule Amol S. , Gaikwad Dhananjay N. , Suryawanshi Dayanand M.
Published: January 2022

The present work describes an efficient, green, and direct approach for the synthesis of amido
alkyl naphthols via one-pot multicomponent solvent-free reaction (MCR) of substituted aromatic
aldehydes, β-naphthols, and urea by the use of easily available, non-toxic, and cost-effective Lewis
acid catalyst magnesium sulphate (MgSO4.7H2O). The important characteristics of this reaction include
the following: eco-friendly and mild reaction conditions, excellent yields of the products, shorter
reaction time, economically cheaper and environmentally friendly catalyst MgSO4.7H2O. Also, clean
reaction, non-column purification, and operational simplicity are some of the additional significant
features of this approach.
Breast Cancer Risk and Human Papillomavirus Infection: A Bradford Hill Criteria Based Evaluation
Authors: Usman Muhammad , Hameed Yasir , Ahmad Mukhtiar , Jalil Ur Rehman  , Ahmed Hamad , Hussain Muhammad Safdar , Asif Rizwan , Murtaza Muhammad Ghulam , Jawad Muhammad Tayyab , Iqbal Muhammad Junaid
Published: January 2022

Background:

The association between human papillomavirus (HPV) and human breast cancer (BC) has already been thoroughly studied worldwide with contradictory findings. Although the researchers have tried to minimize the conflict using statistical meta-analysis because of its shortcomings, there is still a need to evaluate the correlation between HPV and BC using any additional method.

Objectives:

This study was launched to investigate the correlation between HPV and BC through the application of Bradford Hill criteria postulates.

Methods:

Population-wide studies associating HPV with BC were searched using the PubMed database. Then, the information of HPV burden in BC, normal/benign samples was analyzed, and ultimately Bradford Hill criteria postulates were applied on the collected evidence to explore the relationship between HPV and BC. In addition, to make the outcomes more authentic, we also reviewed the methodologies of previous studies to address the propensity of false results.

Results:

After a careful evaluation of the obtained data against major Bradford Hill criteria postulates, it was noted that all these postulates, including strength, consistency, biological gradient, temporality, plausibility, experiment, specificity, and analogy were not fulfilled.

Conclusion:

The results of the present study have failed to establish a causal association between HPV and BC, but they did suggest HPV as a cause-effective agent or at least a co-participant in the pathogenesis of BC. Because of the weakness of association, particularly the lack of consistency between studies and the lack of effect specificity, more research into Bradford Hill criteria postulates is required.
Contribution of Oncology Pharmacists in Cancer Care: A Need for Quality
Care
Authors: Rawal Kala Bahadur , Mateti Uday Venkat , Shetty Vijith , Shastry Shashidhara Chakrachodi , Joel Juno Jerold , Shetty Shraddha
Published: January 2022

Cancer is known as a disease with a high morbidity and mortality rate. There are several
short-term and long-term complications of cancer, leading to poor quality of life. Cancer in advanced
stage and malignant tumors requiring a multisystem involvement makes the treatment challenging.
The diverse health impact of cancer requires a multidisciplinary approach for treatment.
The oncology pharmacy has facilitated a revolutionary approach for preparing and training specialised
pharmacists to deal with a variety of health challenges faced by cancer patients. Oncology
pharmacists or oncopharmacists are the experts in designing drug therapy and individualizing it in
accordance with the requirements. The conventional and novel role of pharmacists in clinical pharmacy
practice is documented to positively impact the health of cancer patients, including cancer
survivors. Hence, this review tries to summarize the potential role of oncopharmacists.
A Bibliometric Analysis of the Reliability Assessment Technology Based on
Accelerated Degradation
Authors: Li Shiyun , Tang Shujue , Pei Zhi , Lv Ruifeng
Published: January 2022

Background:

In the face of the development trend of high-end manufacturing servitization,
the reliability standard of manufacturing products gradually increases.

Objective:

In order to accurately predict the product life cycle, the accelerated degradation evaluation
technology could be applied to significantly shorten the experiment duration. As the technologies of intelligent
manufacturing and industrial big data develop, the theory of accelerated degradation evolves as
well.

Methods:

Based on the scientific knowledge mapping, co-author network and co-existence network,
22283 pertinent articles since the year 2010 have been collected to conduct a bibliometric study.

Results:

The results show that the accelerated degradation reliability assessment spans over many research
fields, and achieves great development in the mathematical modeling and experiment verification.

Conclusion:

To further the study, more efforts are expected in the areas such as building effective evaluation
systems and enhancing the credibility of the assessment outcomes, as more advanced sensory data
and wireless communication technologies become available.
Prevention and prophylaxis of physiotherapy in sports trauma in volleyball athletes
Authors: Vidal Viviana Romero , Guerrero Ernesto Ross , Muentes Segundo Alcides García , Ávila Adriana Gabriela García , Ávila María Gabriela García
Published: January 2022

Sports injuries in volleyball athletes are a frequent cause of medical consultation at the Provincial Center of Sports Medicine. An intervention study was carried out in the youth category of this sport, with the aim of to evaluate the effectiveness of the application of preventive measures and prophylactic physiotherapy treatment. In the interpretation of results, low back pain was obtained as the most significant with 50%, followed by strains and ligament ruptures with 25%; In the variable traumas and relationship with the variability of the affected regions, the highest percentage was observed in the trunk with lumbar injuries with 33.3%. Most of the population of athletes responded positively with 81.7% after the application of preventive measures and prophylactic physiotherapy treatment, thus demonstrating its effectiveness.
Die Wortbildung des Fering-Öömrang
Authors: Hoekstra J. , Reinders A.-K. , Meissner S. , Weber S.
Published: January 2022

A comprehensive overview of the word formation of the North Frisian dialects is a desideratum of Frisian linguistics. In this article we provide a brief survey of the most important compositional and derivational patterns in Fering-Öömrang, the North Frisian dialect of Feer/Föhr and Oomram/Amrum.
In minimalisearder yn 'e Burmania-sprekwurden
Authors: Slofstra B.
Published: January 2022

In Early Modern Frisian, the word combination næt ien (literally: ‘not one’, ‘not a’) had a rather specific meaning. When someone said (s)he “understood næt ien bijt (‘not a bit’) of yesterday’s sermon”, (s)he meant to convey in a rhetorical way that the whole sermon was incomprehensible to him (or her). Expressions like (not) a bit are known as minimisers in the linguistic literature. In present-day Westerlauwers Frisian, the identical word combination net in (‘not a’) normally has a different meaning. As a result, today’s readers are prone to misinterpret these Early Modern mini¬miser expressions. Likewise, the same readers would easily overlook the very similar word combination næt en (‘not a’) in Early Modern Frisian, where the determiner ien is spelled as en. This looks like a completely innocuous spelling variant in Early Modern Frisian, since orthography was anything but standardised in that period. But in reality, this apparently meaningless spelling variant had a pragmatic function. The spelling en was exclusively used in rhetorical contexts, primarily in combination with mini¬misers, but also in as-similes (‘as tall as a (en) giant’) and with such in predicates like: (he is) such a (en) (fool). In this article, a rhetorical expression listed in the 1641 Burmania Proverbs is used as a case in point. (The Burmania Proverbs constitute an anonymous collection of Frisian proverbs and expressions, in the vein of Erasmus’ Adagia.) The linguistic discoveries discussed in this article lead the way to an improved inter¬pretation, which is absent in a recent authoritative, scholarly commentary on these Proverbs.
Температурная эволюция взаимодействия релаксационных процессов с локальной динамикой на терагерцевых частотах в полимерах с водородными связями
Authors: Рыжов В.А.
Published: January 2022

At terahertz frequencies, the torsional-vibrational motion is associated with dielectric relaxation in disordered solids with hydrogen bonds. The interaction between these processes is still poorly understood, especially at temperatures below the glass transition temperature, which is especially important for molecular mobility in polymers. We have studied polymers with hydrogen bonds (polyamide-6 and polyvinyl chloride) at temperatures from 90 to 400 K in the range 0.25 - 4 THz using far-infrared spectroscopy. Three general features were observed in the spectrum of dielectric losses, ”(a) at temperatures well below the glass transition (Tg), these losses are represented by the low-frequency wing of the absorption peak due to the libration of polymer monomer units. (b) At 0.7Tg <T <Tg, additional temperature-dependent losses are observed, which can be associated with the manifestation of secondary relaxation processes. (c) At temperatures above Tg, primary α-relaxation processes become the dominant contribution to terahertz losses. The results obtained show that the evolution of terahertz losses with temperature is caused by a change in the structure of hydrogen bonds, which, apparently, is universal for systems with similar intermolecular interactions.
Use-wear and residue analysis of knapped stone artefacts from Lepenski Vir and Padina (Serbia)
Authors: Petrović Anđa , Lemorini Cristina , Nunziante-Cesaro Stella , Mihailović Dušan
Published: January 2022

Following a series of published analyses ranging from architecture to prehistoric diet of the Iron Gates’ inhabitants, our research aims to present new results regarding use-wear analysis of knapped stone artefacts from Lepenski Vir and Padina with a particular focus on the transition from Mesolithic to Neolithic in this region. Use-wear and residue analysis are applied using the low and high-power approach by Optical Light Microscope (OLM) observations combined with FTIR analysis.

Based on the results, some of the main activities that took place in Iron Gates are processing of hide, bone, antler, plants, and soft stone. It is very important to highlight the complexity of various processes, which make this already specific area more peculiar. A variety of both simple, but overall, more complex and composite activities are recorded with the elaborate preparation of the used materials, for example, hide. Particular processes, such as butchering, were noted both inside the houses, and also concentrated in precise, specific areas of the settlements, where only tools involved in the processing of hide and meat were found. The data obtained highlight the activities of these advanced hunter-gatherer-fishermen and first farmers communities. Together with spatial analysis, the dynamics and processes in the Late Mesolithic and Early Neolithic are revealed, but also many questions regarding the specialization of the prehistoric settlements on the Danube are posed.
DESIGN OF AN AUTOMATED SYSTEM FOR MEASURING CAR BODIES
Authors: Kuryło Piotr , Frankovský Peter , Papacz Władysław , Delyová Ingrid , Schurger Barbara
Published: January 2022

The work presents and describes selected measurement methods of bodywork geometry. The principle of operation of 3D scanners has been described together with their application in the implementation of vision measurement systems in the automotive industry. The paper also presents methods used to automate measurements in diagnostics and vehicle repair processes. In addition, the work presents the concept of a measurement system which combines the ideas of vision measurements and mechanical repair devices.
Antecedentes de los Estilos de Aprendizaje para Entornos Virtuales
Authors: Álvarez-Torres Jair Hernando , Cuatindioy-Imbachi Jenny , González-Palacio Liliana , Luna-del Risco Mario Alberto , González-Palacio Mauricio , Aguirre-Morales Johnny
Published: January 2022

Introducción: en el contexto de la educación virtual hacen falta investigaciones sobre los estilos de aprendizaje de cada estudiante, que les ofrezca opciones personalizadas para su proceso de aprendizaje. En este proyecto se busca integrar los estilos de aprendizaje a la educación virtual. Para ello se propone incorporar un componente adaptativo a la herramienta de gestión de aprendizaje para facilitar la personalización de contenidos en función de variables como el ritmo, el estilo y las necesidades del estudiante. Objetivo: desarrollar nuevas funcionalidades para una herramienta de gestión de Aprendizaje Basado en Problemas incorporando un componente adaptativo que potencie la colaboración en cursos virtuales a nivel universitario. Materiales y métodos: el método fue abductivo, dividido en tres fases: apropiación teórica, estructuración de la propuesta, y validación. Además, se tiene una fase transversal denominada Transferencia de conocimiento y gestión del proyecto. A la fecha, el proyecto se encuentra en la fase de validación. Resultados:se presentarán los antecedentes teóricos más importantes en relación con los estilos de aprendizaje vistos desde la historia de la pedagogía, pero reconociendo que para el presente la pregunta por el aprendizaje ya no es un objeto de estudio exclusivo de la pedagogía, pues dicho objeto también hace parte de las teorías sicológicas que se ocupan de procesos cognitivos, tal como ocurre con la teoría de David Kolb. Conclusiones: en este momento serían muy apresuradas, puesto que no se ha terminado de ejecutar la tercera fase del proyecto. Este escrito se ubica en la fase uno: apropiación teórica.
Anti-CD19 CAR T as a feasible and safe therapy for refractory/relapsed mixed phenotype acute leukemia (MPAL) patients
Authors: Li Xiangqun , Chen Kylann , Zhang Hailong , Zhang Xian , Yang Junfang , Liu Jing , Zheng Jianwei , Dong Fei , Zhu Yongbo , Yu Jiao , Zhang Hailong , Lu Peihua , Chen Bo
Published: January 2022

Mixed phenotype acute leukemia (MPAL) is a relatively rare and
heterogeneous group of diseases, which account for 2-5% of leukemia. So
far, no optimal treatment regimens have been established for MPAL
patients. CD19 chimeric antigen receptor T (CAR T) therapy have shown
remarkable efficacy in B-ALL patients. In this study, 5 MPAL patients
received CD19 CAR T cell infusion and 3 out of 5 patients (60%)
achieved complete response (CR). 2 of 5 patients had only mild cytokine
release syndrome (CRS). Neurotoxicity was not observed. Our data
indicate that CD19 CAR T therapy is safe and effective for majority
refractory/relapsed (r/r) MPAL patients.
FILAGGRIN AND CYTOKINES IN RESPIRATORY SAMPLES OF PRETERM INFANTS AT VIRAL RESPIRATORY INFECTION RISK
Authors: Rodrigo-Muñoz Jose Manuel , Sastre Beatriz , Sánchez-García Laura , Garcia-Garcia Maria Luz , Pellicer Adelina , González-Carrasco Ersilia , Fabra Celia , Gil-Martinez Marta , Lorente-Sorolla Clara , Garcia-Latorre Raquel , Alcolea Sonia , Casas Inmaculada , Calvo Cristina , Pozo Victoria
Published: January 2022

Background: Respiratory viral infections (RVIs) are frequent in preterm
infants and may have long-term impact on respiratory morbidity,
especially those with bronchopulmonary dysplasia (BDP). The immune
response and respiratory are key defence elements, so the purpose of
this study is to evaluate the immune response regulation and the
respiratory epithelial barrier integrity in the preterm infants
suffering RVIs during Neonatal Intensive Care Unit (NICU) admission.
Materials and methods: Nasopharyngeal aspirate (NPA) was obtained,
separating cells from supernatants. Viral detection was performed by
RT-nested PCR, and gene expression by qPCR. Proteins were detected by
western blot and ELISA or Luminex. Small airway epithelial cells (SAEC)
were stimulated with Poly:IC and/or wounds. Results: Pre-infection
samples from 26 preterm infants that later developed RVIs had less
frequency of filaggrin gene expression and fewer protein levels compared
to 23 noninfected controls. Conversely, filaggrin, IL-1β, MIP-1β, VEGF
and HIF-1α levels were higher in pre-infection supernatant samples,
being infection-risk biomarkers. IL-17A, RANTES, VEGF, and HIF-1α levels
were higher during and post infection, while MCP-1 and amphiregulin were
reduced after infection. Small airway epithelial cells (SAEC) stimulated
by poly:IC reduced filaggrin gene expression and increased its levels at
supernatant. Finally, poly:IC stimulation over SAEC increased TLR3 and
TSLP expression, while reduced AREG. Conclusion: Filaggrin gene
expression and protein quantity was reduced at cellular level of the
NPA, while its secreted levels were increased in basal samples from
infected newborns and in SAEC stimulated with poly:IC. Our findings
highlight the importance of filaggrin as a factor facilitating RVIs.
On strictly enforced mass conservation constraints for modeling the rainfall-runoff process
Authors: Frame Jonathan , Kratzert Frederik , Ullrich Paul , Gupta Hoshin , Nearing Grey
Published: January 2022

It has been proposed that conservation laws might not be beneficial for
accurate hydrological modeling due to errors in input (precipitation)
and target (streamflow) data, and this might explain why deep learning
models (which are not based on enforcing closure) can out-perform
catchment-scale conceptual and process-based models at predicting
streamflow. We test this hypothesis using physics-informed machine
learning and find that: (1) enforcing closure in the rainfall-runoff
mass balance does appear to harm the overall skill of hydrological
models, (2) deep learning models learn to account for spatiotemporally
variable biases in data, however (3) this “closure” effect accounts
for only a small fraction of the difference in predictive skill between
deep learning and conceptual models.
Acute infective endocarditis during COVID-19 pandemic time: the dark side of the moon
Authors: Lorusso Roberto , Calafiore Antonio , Mauro Michele Di
Published: January 2022

The COVID-19 pandemic has remarkably impacted the hospital management
and the profile of patients suffering from acute cardiovascular
syndromes. Among them, acute infective endocarditis (AIE) represented a
rather frequent part of these urgent/emergent procedures. The paper by
Li and colleagues has clearly shown the higher risk features which
patients with diagnosis of AIE presented at hospital admission during
the first part (first and second waves) of the outbreak, often requiring
challenging operations, but fortunately not associated with worse
outcome if compared to results obtained prior to the SARS-2 pandemic.
The report discussed herein presents several other aspects worth of
discussion and comments, particularly in relation to hospital management
and post-discharge outcome which certainly deserve to be highlighted,
but also further investigations.
Influência dos agentes clareadores com alta concentração de peróxidos sobre a rugosidade superficial de diferentes tipos de compósitos
Authors: Vieira Alex Correia , Oliveira Mario Cezar , Andrade Adriana Castro Vieira , Leite Mariana Ferreira , Pimenta Polyana Pedreira , Carneiro Alisson Reinan De Oliveira
Published: January 2022

This study aimed to evaluate the surface roughness of different types of composites after the application of two bleaching agents with high concentrations of peroxides. This study is an in vitro research that evaluated the microparticulate composite resin (Durafill, Heraeus-Kulzer), the microhybrid (Z250, 3M-ESPE), and nanohybrid composites (IPS Em press Direct, Ivoclar Vivadent), that were submitted to the action of 40% hydrogen peroxide (Opalescence Boost PF, Ultradent) and 37% carbamide peroxide (Power Bleaching Office 37%, BM4), simulating in-office dental bleaching. For this, 90 samples were made, 30 for each composite, divided into 9 groups (n = 10): G1, G4, and G7 did not receive any bleaching treatment (control groups); G2, G5, and G8 treated with 40% hydrogen peroxide; and G3, G6, and G9 treated with 37% carbamide peroxide. Each sample was submitted to avaliation of the superficial roughness with a rugosimeter. The data were submitted to statistical analysis using ANOVA and Tukey Test at a level of significance of 1%. There were statistically significant differences (p<0.01) between the control groups and the experimental groups submitted to the use of both bleaching agents, for all composites. The microparticulate composite was the most affected material by the use of these peroxides. Thus, bleaching agents in high concentration were able to negatively affect, increasing the surface roughness value of the three types of composites tested, and care should be taken with their application on restorations made with these restorative materials.
Traumatismo dentário em crianças com transtorno do espectro autista: um olhar no período de pandemia
Authors: Lima Suellen Pestana Moreira Ribeiro de , Cabral Gloria Maria Pimenta , Lima Edmilson Cavalcanti de
Published: January 2022

Autism Spectrum Disorder (ASD) is a change in neurodevelopment, which mainly compromises social interaction and language. The neuropsychological and sensory specificities found in children with ASD explain the great behavioral disorganization in the pandemic period. The main objective of the present study is to describe the prevalence of the exacerbated increase in dental trauma in children with Autism Spectrum Disorder (ASD) in pandemic period by Covid-19, due to behavioral changes triggered by an unexpected break in their routines. They are patients who may have impairment in executive functions, related to the individual’s ability to engage in voluntary actions, with little flexibility and who needs a planned and life-oriented routine. It is clear that the need for predictability and routine is something remarkable for patients with ASD.
Endodontia por trauma dentário associada à reconstrução estética com pino de fibra de vidro e resina composta – relato de caso
Authors: Lemes Letícia Tainá de Oliveira , Gaviolli Emanuela , Santos Tiago Lange dos
Published: January 2022

Dental trauma in young patients is very common in clinical daily life and directly influences the patient’s esthetics and function. The objective of this work is to present a clinical case of a young patient who suffered dental trauma and rehabilitation with Endodontics, cementation of a fiberglass post and restoration of the dental crown with composite resin. Patient AM, 12 years old, attending the Endodontics Specialization at FASURGS, changing a dental trauma with a coronopulpal fracture of the dental element 11, an initial periapical radiograph was performed and it was found the pulp involvement. Exposing the treatment options, the patient and guardian agreed to perform Endodontics and rehabilitate tooth 11 with a fiberglass post and composite resin. Following the treatment plan, the patient was anesthetized and the dental pulp was removed, the root canal system was prepared using 2.5% NaOCl and k # 10 manual and rotary files of the Logic # 25:01, # 25:05, and insertion of MIC (Ultracal). In the second session, the medication was removed and the PQM was completed, filled, a fiberglass post was cemented and the dental element was restored using a silicone guide, which had been previously made. Appropriate planning brings great results with a conservative approach, making it possible to maintain a dental structure that offers comfort, restores aesthetics, and improves the patient’s quality of life.
Qualitative renewal of the type and performance of the employee in the context of digitalization and socialization of the region's economy
Authors: SADYKOV Ramil’ M.
Published: January 2022

Subject. This article deals with the issues related to the digitalization and socialization of the economy of Russia and its regions.
Objectives. The article aims to analyze the labor characteristics of the employee in the context of digitalization and socialization of the economy and identify the main indicators of the qualitative renewal of human capital.
Methods. For the study, I used general scientific research approaches.
Results. The article identifies the elements that form the basis of human capital, and it proposes a model of a socially conscious worker, whose behavior is determined by various factors.
Conclusions. A qualitative renewal of the type and labor characteristics of an employee will lead to the emergence of new forms of labor organization and relations in the production process between personnel and the employer, and cause an increase in knowledge, skills and competencies. Social qualities that form the basis of professional activity, help the individual adapt to new conditions and unleash the individual’s creativity.
SISTEM PENUNJANG KEPUTUSAN DIAGNOSA PENYAKIT ISPA DENGAN METODE NAIVE BAYES
Authors: Halim Emilia
Published: January 2022

The purpose of this research is to facilitate the user to diagnose diseases of acute respiratory infections (ARI). Decision support systems have many methods that can be used by decision makers. One method is naive Bayes methods will help decision makers to make the diagnosis by filling the existing criteria. This final project will implement decision support systems with multiple criteria decision-making methods Naive Bayes for diagnosis of acute respiratory infections (ARI).
PEMBUATAN WEBSITE AKADEMIK PADA SMA YADIKA 2
Authors: Yunika Emmi
Published: January 2022

Academic information system at High School Yadika 2 still done manually. In the data processing is still in the conventional academic with the current data collection system is felt still many shortcomings that happened, because the existing systems still use paper and archival sheet so as to cause the existing data is easily lost or damaged. Development of systems in the form of making a web-based information systems academic at Public High Schools 1 Ngadirojo an information system that provides reports online activity of students in the form of reports student grades and attendance report is concerned with web-based, so it helps the speed and quality in the delivery of information. In addition to the web-based data information can be accessed at a time and place not specified. In this system, the menu can only be accessed by certain users, namely students, teachers and administrators. Information system academic was built using the PHP programming language with database MySql. Expected this System can assist to facilitate the performance of all officer in High School Yadika 2.
KAJIAN TENTANG APLIKASI SISTEM INFORMASI DAN PENGOLAHAN NILAI BERBASIS WEB DAN ANDROID PADA SD BUNDA MULIA
Authors: Natashia Jennifer
Published: January 2022

Development of information technology affects human life, one of which is education. Every half term and increase in class, students will receive report cards so that teachers have to calculate the average value of each student subjects. Therefore, this application is made to petrify calculate the average value and help parents find out information about the activities of students in the school. The final value is obtained by first calculating the average task and quiz, then summing this average with UTS and UAS. After getting the results of that amount then the result is divided by 4.
PEMBUATAN APLIKASI DAN DATABASE KERUSAKAN PADA MOTOR UNTUK SISTEM PAKAR
Authors: Fernando Nikolas Patrick , Lubis Chairisni , Dharmawan Agus Budi
Published: January 2022

Sistem pakar adalah sistem yang mengambil pengetahuan manusia dan memasukanya ke komputer sehingga komputer dapat menyelesaikan masalah seperti yang biasa dilakukan oleh para ahli Aplikasi komputer ditujukan untuk membantu mengambil keputusan persoalan dalam bidang tertentu. Pengambilan keputusan tersebut dengan cara menggabungkan kesimpulan dengan basis pengetahuan yang diberikan oleh satu atau lebih pakar dalam bidang tertentu.
Lógicas temporales del poder. Una aproximación a las relaciones entre poder y tiempo social
Authors: Cristiano Javier
Published: January 2022

El artículo se plantea como contribución a una teorización sistemática de las relaciones entre poder y tiempo social. Se parte de considerar al tiempo desde una perspectiva sociológica, como un conjunto de prácticas, representaciones y sentidos que se construyen socialmente. Dentro del amplio espectro de cuestiones que pueden plantearse entre el tiempo así definido y el poder, se selecciona en particular la que corresponde al ejercicio del poder y al modo en que hace uso estratégico de variables temporales. Se identifican y describen en concreto diez lógicas temporales del poder: expropiar, priorizar, hacer esperar, sorprender, apurar, dilatar/precipitar, prometer, amenazar, indeterminar y olvidar/recordar. Se postula que cada una constituye una forma cuyo contenido empírico es cambiante y puede situarse tanto a niveles micro como meso y macro del análisis social.

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The article is proposed as a contribution to a systematic theorization of the relations between power and social time. It starts from considering time from a sociological perspective, as a set of practices, representations and meanings that are socially constructed. Within the broad spectrum of questions that can arise between the time thus defined and power, the one that corresponds to the exercise of power and the way in which it makes strategic use of temporal variables is selected in particular. Ten temporal logics of power are specifically identified and described: expropriate, prioritize, make wait, surprise, rush, delay / rush, promise, threaten, indeterminate and forget / remember. It is postulated that each one constitutes a form whose empirical content is changing and can be situated at both the micro, meso and macro levels of social analysis.
Las formas de vida y su aceleración: Un diálogo entre las perspectivas de Rahel Jaeggi y Hartmut Rosa
Authors: Gros Alexis
Published: January 2022

En este artículo me propongo reflexionar acerca de las consecuencias de la aceleración tardomoderna en las formas de vida, esto es, en los órdenes culturales colectivos que encauzan y organizan la coexistencia cotidiana. La estrategia que utilizaré para ello consiste en establecer un diálogo entre la teoría de la aceleración social de Hartmut Rosa y la concepción de las formas de vida de Rahel Jaeggi. El texto está estructurado en tres secciones. En la primera de ellas (1) reconstruyo los lineamientos fundamentales de la posición de Jaeggi. En la segunda (2), presento muy brevemente la concepción rosiana de la aceleración. La tercera y última sección (3) está dedicada a poner en vinculación ambas perspectivas.

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In this article, I intend to reflect on the effects of late modern acceleration on forms of life, that is, on the collective cultural orders that organize everyday coexistence. The strategy I will use is to establish a dialogue between Hartmut Rosa's theory of social acceleration and Rahel Jaeggi's account of life forms. The text is structured in three sections. In the first one (1), I reconstruct the main outlines of Jaeggi's position. In the second (2), I present very briefly Rosa’s account of social acceleration. The third and last section (3) will be dedicated to establishing a dialogue between both perspectives.
Relación entre el proceso de aculturación y las actitudes hacia comportamientos sexuales en personas de origen marroquí
Authors: Blanc Molina Andrea
Published: January 2022

Introducción: El fenómeno de las migraciones internacionales y la influencia de la cultura en la sexualidad han conducido al desarrollo de estudios que relacionan la aculturación con las actitudes sexuales. Sin embargo, hasta la fecha, ningún estudio ha relacionado el proceso de aculturación con las actitudes sexuales en España. Por ello, el objetivo del estudio fue relacionar el proceso de aculturación con las actitudes hacia comportamientos sexuales en personas de origen marroquí en este país.Método: Participaron un total de 110 personas de origen marroquí (51.8% mujeres) entre 18 y 30 años. Se administró de forma online una escala de actitudes hacia comportamientos sexuales, dos escalas sobre preferencias de aculturación en los ámbitos más privados propuestos por el modelo ampliado de aculturación relativa (MAAR) e indicadores sobre preferencias y estrategias en el ámbito sexual.Resultados: Los resultados muestran que en las mujeres existe relación negativa entre el mantenimiento de la cultura de origen en los ámbitos del MAAR y las actitudes hacia comportamientos sexuales y en los hombres existe relación positiva entre la adopción de la cultura de acogida y dichas actitudes. Los resultados también muestran que las preferencias de adopción y la adopción de las costumbres sexuales de la cultura española se relacionan positivamente con dichas actitudes.Discusión: Estos resultados confirman la importancia del proceso de aculturación en las actitudes hacia comportamientos sexuales en las personas de origen marroquí en España.
Multiple lessons learned from a single case: Complications from pineal germinoma management
Authors: Al-Saiari Sultan , Asiri Faisal A. , Farag Ahmed A. , Alghamdi Faisal , Rezk Essam , Al Orabi Khalid , Abdoh Mohammad Ghazi , Rasheedi Jameel Khalid , Moshref Rana
Published: January 2022

Background:

Pineal tumors are uncommon tumors that affect <1% of adults, with 50% of them being germinomas. A combination of endoscopic third ventriculostomy (ETV) and tumor biopsy is usually used. Cerebral vasospasm in association with aneurysmal subarachnoid hemorrhage (aSAH) has been extensively studied. However, at least according to the research, this is not the case in intraventricular hemorrhage (IVH) cases. We present a case with two distinct findings: (1) an unexpected large IVH following the removal of an external ventricular drain (EVD) in a patient who had undergone ETV and tumor biopsy, resulting in severe clinical vasospasm and (2) incidental pineal region germinoma regression on follow-up magnetic resonance imaging (MRI) without any prior adjuvant chemoradiation to explain such regression.

Case Description:

The authors describe an 18-year-old male patient who had a routine, uneventful combined ETV and tumor biopsy, as well as the placement of an EVD. Histopathological examination revealed germinoma. His postoperative course was complicated by IVH after EVD removal, which resulted in clinical vasospasm. Without any prior adjuvant chemoradiation, follow-up MRI of the b rain revealed a significant reduction in the size of the germinoma as well as reconstitution of the patency of the previously obstructed aqueduct of Sylvius.

Conclusion:

The take-home message from this case is that in the case of postoperative clinical deterioration in a patient with concurrent IVH and ETV, a high index of suspicion for vasospasm is required, as this may allow a significant amount of blood to pass down to the basal cisterns. Early detection and management of clinical vasospasm are critical for a better neurological outcome. Furthermore, unexpected tumor size changes can occur due to a variety of factors, so recent preoperative MRI of the brain should be obtained in the lead-up to surgery, and postoperative computed tomography should be used sparingly to avoid radiation-related tumor changes.