bluuebunny/crossref_metadata_2025 huggingface dataset:
LN: A Flexible Algorithmic Framework for Layered Queueing Network Analysis
Authors: Casale Giuliano , Gao Yicheng , Niu Zifeng , Zhu Lulai
Published: November 2023

Layered queueing networks (LQNs) are an extension of ordinary queueing networks useful to model simultaneous resource possession and stochastic call graphs in distributed systems. Existing computational algorithms for LQNs have primarily focused on mean-value analysis. However, other solution paradigms, such as normalizing constant analysis and mean-field approximation, can improve the computation of LQN mean and transient performance metrics, state probabilities, and response time distributions. Motivated by this observation, we propose the first LQN meta-solver, called LN, that allows for the dynamic selection of the performance analysis paradigm to be iteratively applied to the submodels arising from layer decomposition. We report experiments where this added flexibility helps us to reduce the LQN solution errors. We also demonstrate that the meta-solver approach eases the integration of LQNs with other formalisms, such as caching models, enabling the analysis of more general classes of layered stochastic networks. Additionally, to support the accurate evaluation of the LQN submodels, we develop novel algorithms for homogeneous queueing networks consisting of an infinite server node and a set of identical queueing stations. In particular, we propose an exact method of moment algorithms, integration techniques for normalizing constants, and a fast non-iterative mean-value analysis technique.
Characterization of neuromuscular transmission and projections of muscle motor neurons in the rat stomach
Authors: Di Natale Madeleine R. , Hunne Billie , Stebbing Martin J. , Wang Xiaokai , Liu Zhongming , Furness John B.
Published: November 2023

This study provides a detailed mapping of nerve transmission to the circular muscle of the different anatomical regions of rat stomach. It shows that excitatory and inhibitory influences extend around the gastric circumference and that there is a summation of neural influence that allows for finely graded control of muscle tension and length. Nerve-mediated electrical events are qualitatively and quantitatively different between regions, for example, excitatory neurons have direct effects on fundus but not antral muscle.
Bariatric surgery decreases the capacity of plasma from obese asthmatic subjects to augment airway epithelial cell proinflammatory cytokine production
Authors: Peña-García Paola E. , Fastiggi V. Amanda , Mank Madeleine M. , Ather Jennifer L. , Garrow Olivia J. , Anathy Vikas , Dixon Anne E. , Poynter Matthew E.
Published: November 2023

This longitudinal study following subjects with asthma and obesity reveals that weight loss following bariatric surgery decreases the capacity for plasma to augment proinflammatory cytokine secretion by human bronchial epithelial cells, implicating that circulating but not adipocyte-derived factors are important modulators in obese asthma.
The Impact and Correlation of Anxiety and Depression on Pressure Pain Threshold of Acupoints in Patients with Chronic Pelvic Inflammatory Disease
Authors: Liao Chenxi , Tan Yu , Wang Kai , Wen Xin , Hu Xiang , Huang Yefang , Li Ying
Published: November 2023

Background. Chronic pelvic inflammatory disease (CPID) is a clinically common gynecological disease. Patients experience chronic pelvic pain and often accompany with emotional dysfunction. However, the impact and correlation of anxiety and depression on pain sensitization is not completely known. Objective. To explore the differences and correlations among anxiety, depression, and pressure pain threshold (PPT) of acupoints in patients with CPID. Methods. One hundred and forty-seven patients with CPID were recruited. The Visual Analog Scale (VAS) and short-form McGill Pain Questionnaire (SF-MPQ) were used to assess pain. Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were used to evaluate the emotional state of patients. The PPT of acupoints was collected using an electronic Von Frey by two licensed acupuncturists. Results. The CPID patients were divided into anxiety-depression group (group A) or nonanxiety-depression group (group B), according to the SAS and SDS scores. Finally, there were 73 patients in group A and 74 patients in group B. Group A had significantly higher SAS, SDS, VAS, and SF-MPQ scores than group B (

P
<
0.05

). In addition, significant differences were observed in the PPTs of ST28 (R), ST29 (R), SP10 (R), SP9 (R), SP9 (L), ST36 (R), and LR3 (L) between the two groups (

P
<
0.05

). No considerable differences in PPTs at the other acupoints were observed between the two groups. SAS scores showed a positive correlation with PPTs of ST29 (R), SP10 (R), SP9 (L), ST36 (R), and LR3 (L). No remarkable correlation was observed between the SDS scores and PPTs. Conclusion. Anxiety and depression can affect the PPT of some acupoints in CPID patients, which may provide a reference for acupoint selection for acupuncture treatment of CPID with emotional disorders. This trial is registered with ChiCTR2100052632.
Prediction Models for Return of Spontaneous Circulation in Patients with Cardiac Arrest: A Systematic Review and Critical Appraisal
Authors: Cheng Pengfei , Yang Pengyu , Zhang Hua , Wang Haizhen
Published: November 2023

Objectives. Prediction models for the return of spontaneous circulation (ROSC) in patients with cardiac arrest play an important role in helping physicians evaluate the survival probability and providing medical decision-making reference. Although relevant models have been developed, their methodological rigor and model applicability are still unclear. Therefore, this study aims to summarize the evidence for ROSC prediction models and provide a reference for the development, validation, and application of ROSC prediction models. Methods. PubMed, Cochrane Library, Embase, Elsevier, Web of Science, SpringerLink, Ovid, CNKI, Wanfang, and SinoMed were systematically searched for studies on ROSC prediction models. The search time limit was from the establishment of the database to August 30, 2022. Two reviewers independently screened the literature and extracted the data. The PROBAST was used to evaluate the quality of the included literature. Results. A total of 8 relevant prediction models were included, and 6 models reported the AUC of 0.662–0.830 in the modeling population, which showed good overall applicability but high risk of bias. The main reasons were improper handling of missing values and variable screening, lack of external validation of the model, and insufficient information of overfitting. Age, gender, etiology, initial heart rhythm, EMS arrival time/BLS intervention time, location, bystander CPR, witnessed during sudden arrest, and ACLS duration/compression duration were the most commonly included predictors. Obvious chest injury, body temperature below 33°C, and possible etiologies were predictive factors for ROSC failure in patients with TOHCA. Age, gender, initial heart rhythm, reason for the hospital visit, length of hospital stay, and the location of occurrence in hospital were the predictors of ROSC in IHCA patients. Conclusion. The performance of current ROSC prediction models varies greatly and has a high risk of bias, which should be selected with caution. Future studies can further optimize and externally validate the existing models.
A Metabolic Axis of Immune Intractability
Authors: Hinshaw Dominique C. , Patel Meet , Shevde Lalita A.
Published: November 2023

Immune cells in the tumor niche robustly influence disease progression. Remarkably, in cancer, developmental pathways are reenacted. Many parallels between immune regulation of embryonic development and immune regulation of tumor progression can be drawn, with evidence clearly supporting an immune-suppressive microenvironment in both situations. In these ecosystems, metabolic and bioenergetic circuits guide and regulate immune cell differentiation, plasticity, and functional properties of suppressive and inflammatory immune subsets. As such, there is an emerging pattern of intersection across the dynamic process of ontogeny and the ever-evolving tumor neighborhood. In this article, we focus on the convergence of immune programming during ontogeny and in the tumor microenvironment. Exemplifying dysregulation of Hedgehog (Hh) activity, a key player during ontogeny, we highlight a critical convergence of these fields and the metabolic axis of the nutrient sensing hexosamine biosynthetic pathway (HBP) that integrates glucose, glutamine, amino acids, acetyl CoA, and uridine-5′-triphosphate (UTP), culminating in the synthesis of UDP-GlcNAc, a metabolite that functions as a metabolic and bioenergetic sensor. We discuss an emerging pattern of immune regulation, orchestrated by O-GlcNAcylation of key transcriptional regulators, spurring suppressive activity of dysfunctional immune cells in the tumor microenvironment.
Supplemental Figure S3 from Exogenous Sequences in Tumors and Immune Cells (Exotic): A Tool for Estimating the Microbe Abundances in Tumor RNA-seq Data
Authors: Hoyd Rebecca , Wheeler Caroline E. , Liu YunZhou , Jagjit Singh Malvenderjit S. , Muniak Mitchell , Jin Ning , Denko Nicholas C. , Carbone David P. , Mo Xiaokui , Spakowicz Daniel J.
Published: November 2023

The number of edges per node for the nodes of a random network.
Metastatic Ductal Eccrine Adenocarcinoma with Excellent Response to Immunotherapy
Authors: Fadhil Matthew , Lochhead Alistair , Trinh Hon , Brungs Daniel
Published: November 2023

Eccrine carcinoma, a subtype of which is ductal eccrine adenocarcinoma (DEA), is a rare cutaneous malignancy. For metastatic eccrine carcinoma, there are very limited data to guide treatment. Conventional chemotherapy is of limited benefit and there is only a small body of evidence for the use of immunotherapy in non-DEA eccrine carcinomas. We report the first case of metastatic DEA treated with a multimodality approach including surgery, radiotherapy, and immunotherapy, with an excellent prolonged response to pembrolizumab, and provide a review of the literature on pathological and management aspects for this rare tumour subtype. A 60-year-old male with a history of pT1N0M0 left scalp DEA, managed 2 years prior with excision and adjuvant radiotherapy, represented with a symptomatic right pontine metastasis. Imaging demonstrated intracranial, pulmonary, and hilar disease; biopsy of the cranial and lung lesions showed metastatic adenocarcinoma, morphologically similar to the previously resected scalp DEA. The patient was treated with stereotactic resections of his pontine metastases and adjuvant cranial radiotherapy, then commenced on immunotherapy with pembrolizumab. The patient has completed 21 months of pembrolizumab with a significant radiological response of the pulmonary and hilar disease and nil evidence of intracranial recurrence or further metastases. In this case report, we provide the first evidence of efficacy of immunotherapy in metastatic DEA, demonstrating an excellent and prolonged response of metastatic DEA to pembrolizumab. Further research is required to better establish the role of immunotherapy within the management protocol for this uncommon but aggressive tumour subtype.
Gout Affecting the Nail Unit: Report of Two Cases and Literature Review
Authors: Hu Jeffery Z. , Jellinek Nathaniel J. , Hinshaw Molly A.
Published: November 2023

Background: Gout is a depositional, inflammatory disorder that is rarely reported to affect the nail unit. Cases of gout involving the nail unit are likely under-recognized and therefore underreported. We present two cases of tophaceous gout affecting the nail unit and a literature review of the various presentations. Summary: Five cases of gout were identified to affect the nail unit. In all cases, these presented as white hyperkeratotic papulonodules with associated nail dystrophy. Chalky discharge was seen in three of the five cases. Nine cases were identified to have demonstrated pseudocarcinomatous changes that histopathologically mimic squamous cell carcinoma (SCC). Literature review highlights a range of findings including subclinical deposits of uric acid in the nail, onychoschizia, onychorrhexis, and Beau’s line. Key Messages: Physicians should be aware of the subtle and nonspecific clinical findings of gout, which may be easily misconstrued for other pathological entities.
The Value of Prostate-Specific Antigen Density in Combination with Lesion Diameter for the Accuracy of Prostate Cancer Prediction in Prostate Imaging-Reporting and Data System 3 Prostate Lesions
Authors: Senel Samet , Koudonas Antonios , Uzun Emre , Ceviz Kazim , Tastemur Sedat , Ozden Cuneyt , Karakan Tolga , Kiran Merve Meryem , Sarialtin Firathan , Olcucuoglu Erkan
Published: November 2023

Introduction: The aim of the study was to investigate the value of prostate-specific antigen density (PSAD) and lesion diameter (LD) combination in prostate cancer (PCa) detection. Methods: 181 patients who were detected to have prostate imaging-reporting and data system (PI-RADS) 3 lesions in mpMRI and underwent prostate biopsies were included in the study. Demographic, clinical, and pathological data of all patients were evaluated. The patients were divided into four groups according to PSAD and LD status (PSAD <0.15 ng/mL/cc + LD <1 cm, PSAD <0.15 ng/mL/cc + LD ≥1 cm, PSAD ≥0.15 ng/mL/cc + LD <1 cm, and PSAD ≥0.15 ng/mL/cc + LD ≥1 cm). Diagnostic ability for PCa and clinical significant PCa (csPCa) was evaluated by PSAD and LD. Results: PSAD ≥0.15 ng/mL/cc (OR = 6; 95% Cl = 2.847–12.647; p < 0.001), LD ≥1 cm (OR = 7.341; 95% confidence interval [CI] = 2.91–18.52; p < 0.001), and combination of PSAD ≥0.15 ng/mL/cc and LD ≥1 cm (OR = 10.023; 95% CI = 4.32–23.252; p < 0.001) were associated with PCa detection rates. The most sensitivity, specificity, negative, and positive predictive values were found in PSAD ≥0.15 ng/mL/cc + LD ≥1 cm group for both PCa and csPCa detection (48.8%, 92%, 85.2%, and 65.6% for any PCa detection; 66.7%, 85.2%, 97.3%, and 24.2% for csPCa detection, respectively). Conclusion: The presence of PSAD ≥0.15 ng/mL/cc or LD ≥1 cm in mpMRI of patients with PI-RADS 3 lesions is associated significantly with the finding of PCa and particularly with the detection of csPCa.
Patterns and Implications of Intracranial Atherosclerosis in Anterior and Posterior Circulation Identified by High-Resolution Vessel Wall Imaging
Authors: Zheng Lu , Li Jia , Yang Wenjie , Lam Ho-Ching Chloe , Wong K.S. Lawrence , Chu Winnie , Leung Thomas Wai Hong , Chen Xiangyan
Published: November 2023

Introduction: Anterior and posterior circulation atheroscleroses differ in vascular risk factors and stroke patterns. Posterior circulation stroke has worse clinical outcomes. However, few studies described the differentiation of plaque features between anterior and posterior circulation atheroscleroses via high-resolution vessel wall imaging (HR-VWI). We aimed to compare the plaque imaging features between anterior and posterior circulations to highlight the relevance of plaque imaging features to clinical events of ischemic stroke. Methods: Prospective data from a HR-VWI cohort of adult patients with acute ischemic stroke or transient ischemic attack were retrospectively analyzed. Quantitative and qualitative measurements of atherosclerotic plaques along the middle cerebral arteries (MCAs), the basilar artery (BA), and the vertebral arteries (VAs) were conducted on HR-VWI. Vessels with stenotic degrees over 30% were identified on the matched time-of-flight magnetic resonance angiography (TOF-MRA) and visually classified into normal, irregular, stenotic, and occluded. The sensitivity, specificity, positive and negative predictive values for TOF-MRA in detecting abnormal vessels were calculated by using quantification on the basis of HR-VWI findings as the reference standard. Results: One hundred and one patients (median age, 64 years old; 62.4% males) were included in this study. A total of 292 plaques were identified, with 152 in the MCAs, 35 in the BA, and 105 in the VAs. The VAs possessed significantly higher enhancement index (EI) (median 38.37 vs. 18.40, p <0.001), more plaques with positive remodeling (76.2% vs. 57.2%, p = 0.002) and intraplaque hypo-intensity (43.8% vs. 12.5%, p <0.001) than the MCAs. The MCAs presented with more intraplaque hemorrhage (IPH) (20.4% vs. 8.6%, p = 0.014) than the VAs. The sensitivity and specificity of TOF-MRA for evaluating luminal stenosis were 89.0 (82.5–93.4) and 66.7 (24.1–94.0) in anterior circulation, respectively, and were 75.2 (66.7–82.2) and 27.3 (7.3–60.7) in posterior circulation, respectively. Conclusion: Our findings might elucidate the clinical events and outcomes in anterior and posterior circulation stroke. Posterior circulation atherosclerosis had higher EI and more plaques with hypo-intensity, suggesting a heavier atherosclerosis burden. Positive remodeling pattern in posterior circulation atherosclerosis might create an impression of “wider” vascular lumen, leading to possible underestimation of atherosclerosis burden of posterior circulation on TOF-MRA as compared to HR-VWI. Besides, anterior circulation atherosclerosis with IPH might be associated with plaque rupture and artery-to-artery embolism. Future studies are needed to verify these findings.
Controlando todas as etapas de produção: crowdfunding e o quadrinista/empresário
Authors: Carvalho André Pereira de
Published: November 2023

No processo de produção de quadrinhos via crowdfunding (financiamento coletivo), os quadrinistas são obrigados a exercer todas as funções do processo de produção de seus quadrinhos: desde os aspectos artísticos (como roteiro e desenho) quanto técnicos (diagramação, impressão e logística). Esta incorporação de todas as funções pelo artista reflete de maneira clara e direta um perfil “desejado” aos quadrinistas no Brasil: empresários de si, e não apenas artistas desvinculados dos processos burocráticos envolvendo seus quadrinhos. Esta profissionalização reflete tanto o exigente e competitivo mercado de quadrinhos brasileiro, quanto a lógica que impera no meio dos quadrinhos, determinando que o sucesso ou não do artista seja fruto única e exclusivamente de sua habilidade artística e empresarial – a lógica da meritocracia.
Cracking the Neural Code of How the Brain Represents Time May Make the Dualistic Stance Obsolete
Authors: van Wassenhove Virginie
Published: November 2023

This is an invited commentary on the position paper of Gruber, Block and Montemayor (2022). First, I oppose the premise in Gruber et al.’s proposal according to which there exists a ‘real’ and an ‘illusory’ time. Second, our knowledge about the universe is hypothesized, tested, and verified by the most complex physical systems known to date (brains) hence postulating the coexistence of an ‘absolute’ and a ‘real’, or an ‘illusory’ and a ‘nonillusory’ time might be unnecessary. Instead, and parsimoniously, (organic or atomic) measuring devices for duration, simultaneity, order, and so forth, have variable precision. The most exquisite clock is atomic, a good enough one for survival on Earth is at the scale of neural networks. A difference between measuring devices and brains is that the latter compute on stored temporal information. Last, I suggest additional gadgets for the Information Gathering and Utilizing Systems (IGUs) proposal. In sum, I oppose some of the theoretical premises while lending support to the idea that representing temporal statistics is a useful heuristics for some aspects of temporal cognition. From the cognitive neuroscience standpoint, IGUs are compatible with information-theoretic approaches, and with current Bayesian and predictive models implemented in neural systems, in which brains code information and compute on symbolic representations.
Assessing RRFS versus HRRR in Predicting Widespread Convective Systems over the Eastern CONUS
Authors: Grim Joseph A. , Pinto James O. , Dowell David C.
Published: November 2023

This study provides a comparison of the operational HRRR version 4 and its eventual successor, the experimental Rapid Refresh Forecast System (RRFS) model (summer 2022 version), at predicting the evolution of convective storm characteristics during widespread convective events that occurred primarily over the eastern United States during summer 2022. In total 32 widespread convective events were selected using observations from the MRMS composite reflectivity, which includes an equal number of MCSs, quasi-linear convective systems (QLCSs), clusters, and cellular convection. Each storm system was assessed on four primary characteristics: total storm area, total storm count, storm area ratio (an indicator of mean storm size), and storm size distributions. It was found that the HRRR predictions of total storm area were comparable to MRMS, while the RRFS overpredicted total storm area by 40%–60% depending on forecast lead time. Both models tended to underpredict storm counts particularly during the storm initiation and growth period. This bias in storm counts originates early in the model runs (forecast hour 1) and propagates through the simulation in both models indicating that both miss storm initiation events and/or merge individual storm objects too quickly. Thus, both models end up with mean storm sizes that are much larger than observed (RRFS more so than HRRR). Additional analyses revealed that the storm area and individual storm biases were largest for the clusters and cellular convective modes. These results can serve as a benchmark for assessing future versions of RRFS and will aid model users in interpreting forecast guidance.
An Experimental Investigation of Hazard Statement Compliance in Procedures Using Eye Tracking Technology: Should Task be Included in the C-HIP Model?
Authors: Hendricks Joseph W. , Peres S. Camille
Published: November 2023

Objective

Using eye tracking technology, this study sought to determine if differences in hazard statement (HS) compliance based on design elements are attributable to attention maintenance (AM).

Background

Recent empirical work has demonstrated counter-intuitive findings for HS designs embedded in procedures. Specifically, prevalent HS designs in procedures were associated with lower compliance.

Method

The current study utilized eye tracking technology to determine whether participants are attending to HSs differently based on the inclusion or absence of visually distinct HS design elements typically used for consumer products. We used two different designs that previously yielded the largest gap in HS compliance. In a fully-crossed design, 33 participants completed four rounds of tasks using four procedures with embedded HSs. To assess AM, eye tracking was used to measure gaze and fixation duration.

Results

The results indicated there are differences in AM between the two designs. The HSs that included elements traditionally considered effective in the consumer products literature elicited lower fixation duration times, and were associated with lower compliance. However, AM did not mediate the design effect on compliance.

Conclusions

The study results suggest the design of HSs are impacting individuals as early as the AM stage of the C-HIP model. The absence of HS design-AM-compliance mediation suggests other C-HIP elements more directly explain the HS design-compliance effects.

Application

These results provide more evidence that the communication of Health, Environment, and Safety information in procedures may need to be different from those on consumer products, suggesting design efficacy may be task dependent.
Manufacturing woven carbon fabrics with electrode function via high-pressure spray of active lithium-ion particles
Authors: Han Zhibin , Feng Yuncong , Zhang Wanrui , Xiong Yifeng , Zhang Weizhao
Published: November 2023

In this paper, an innovative approach was presented to manufacture woven carbon fabric cathodes via high-pressure spray to coat LiFePO4 (LFP), acetylene black (AB) and polyvinylidene fluoride (PVDF) onto carbon fibers. The fabrics were desized to improve conductivity prior to coating. Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) were adopted to ensure that the selected process parameters could achieve complete removal of the polymer sizing and dispersion of the LFP particles on both the spray surface and inner architecture of the fabrics. The subsequent electrochemical characterization showed that the fabric cathodes could, on average, produce excellent specific capacities of over 110 mAh/g and areal capacities of over 3.0 mAh/cm2 with good rate performance. With 98% efficiency and 0.97 retention after 100 cycles, the cathodes also depicted superb long-cycle performance, meaning that the coating with electrochemical activity could adhere firmly to the fiber surface.
Football Spectatorship: Are the Home Office Statistics a Reliable Indicator for Measuring Football-Related Violence & Disorder?
Authors: Lowerson Ashley Jane
Published: November 2023

Despite the best efforts of successive governments and the police, football-related violence and disorder still exist. The extent of the problem is not clear due to the unreliability of the data used to monitor this behaviour. The behaviour of football spectators has received significant attention in areas of psychology, criminology, and law, yet there is no single documented piece of research that measures the reliability of the evidence used to monitor spectator behaviour. This means that data of uncertain provenance is being used to evaluate methods of controlling football spectators and to inform government policy and policing strategies. This article will highlight issues with the reliability of the dataset and caution that such information should not be used without better contextualisation as the basis for policing, prosecution, and legislative strategies. The context of this article does not easily ﬁt into the existing classiﬁcation of primary or secondary and qualitative or quantitative research. As such, this article provides a novel approach to understanding the Home Office statistics by obtaining the data used to monitor football-related arrests through the use of Freedom of Information requests. In doing so, the article is the first to assess the methodology underpinning the government's data, making a significant and original contribution to the existing literature and policing practices in this area. As a result of this analysis, the article recommends that a standardised system for logging the data is needed to provide more reliable evidence of the scale of football violence and disorder in England and Wales. More comprehensive and reliable data can then counter prevailing media narratives regarding the behaviour of football supporters and provide a solid evidence base for police and governmental action.
Involuntary Voluntary Action
Authors: Elkington Amy
Published: November 2023

Voluntariness is an essential factor in determining if someone should be held legally responsible for his actions. Equally, voluntary actions of the victim in certain situations can break the chain of causation, thus removing criminal liability from the defendant. To create the desired certainty in the law a clear definition of voluntary action is essential, however, this article highlights how such a definition remains elusive. The binding ratio in Kennedy, that a victim's free, informed and deliberate actions can break the chain of causation, has been applied in an inconsistent way in R v Wallace. As a consequence, the law relies on a moralistic judgment in determining whether a defendant should be criminally liable for his actions. Thus, causing complexity and confusion in determining when actions can be deemed voluntary. R v Field has caused further uncertainty by holding that voluntarily choosing to drink whisky can be said to be an involuntary action. It is concluded that R v Field could have instead been viewed more clearly through the lens of omissions. This would have enabled established legal principles to be applied without the resulting challenges that R v Field has caused in determining what is voluntary action.
Dehumanization Through Degendering the Death Row Inmate: A Systematic Review of the Research
Authors: Schulze Corina
Published: November 2023

Purpose: To provide an overview of how gender identity is treated in death row research. Methods: By use of a systematic review of 56 peer-reviewed journal articles that were identified as empirical, employing either qualitative or quantitative data, concepts measuring the use of gender and race identity were developed. Results: Findings were presented by the methodology employed, area of research, sample composition, and key concepts which included the use of gendered terminology in titles, abstracts, and manuscripts, as well as by the author(s)’s gender identities. Conclusion: In general, regardless of methodology or area of research, death row research does not account for the effects of gender or intersectional identities unless the sample participants or subject matter pertains to women.
“I Have Accepted My Father’s Death; I was not Sad but Relieved.” Adaptive Grief Responses for Bereaved Dementia Family Caregivers: A Scoping Review
Authors: O’Donnell Mary Gemma , Baker Zachary G.
Published: November 2023

This scoping review explores findings from the psychological and medical literature on the adaptive grieving experiences of bereaved dementia family caregivers and integrates what healthcare professionals can do to support bereaved dementia family caregivers transition into a post-death role. Bereaved dementia family caregivers are particularly susceptible to prolonged grief disorder post-death due to the protracted caregiving demands and progressive course of the illness. The mention of caregiver grief while the person with dementia is living is quite common in the literature; however, limited research focuses on the bereaved dementia family caregiver and the methods they use to grieve adaptively. Three overarching adaptive grieving themes emerged from the review: 1) social health, 2) emotional and spiritual fitness, and 3) reclaiming activities. Given the growing prevalence of bereaved family dementia caregivers, understanding how they might most adaptively grieve and experience the greatest possible well-being should be a top focus for research.
Emergent volunteerism in missing person cases — A Dutch case study
Authors: Lam Jerôme , Kop Nicolien
Published: November 2023

In missing person cases, police often face spontaneous searches by citizens. This study examined the involvement of police and citizens in a well-known Dutch case. It shows that the relationship between police and volunteers is not static, but changes over time. Initially, citizens are more quickly organized and take charge. As the investigation progresses, different types of volunteers are incorporated into the police structure. Citizens pose dilemmas regarding direction and information sharing, but provide valuable search capacity and expertise. The results show the importance of not opposing citizen initiatives, but rather making contact, establishing structure and coordinating efforts early on.
Development and Verification of the Wellness Tourism Experience Scale
Authors: Li Yaoqi , Deng Qiaoqiao , Peng Fei , He Mang
Published: November 2023

Wellness tourism is a significant way to improve physical, psychological, and spiritual aspects. However, an appropriate scale for measuring the wellness tourism experience in academic research remains lacking. Most existing research had measured wellness tourism experience using full or part of the well-established tourism experience scales, ignoring the unique context of wellness tourism. Considering these issues, this paper first clarifies the essential connotations of the wellness tourism experience. Then, following the scale development process (literature review, content analysis, expert scoring, and two rounds of large-scale questionnaire surveys), this paper proposes the wellness tourism experience as a multidimensional construct comprising three dimensions, including “regain health,” “escape from stress” and “discover oneself.” This study provides a scientific and reliable measurement tool for further exploration of the antecedents and consequences of the wellness tourism experience.
Characteristics of Missing Data in Single-Case Experimental Designs: An Investigation of Published Data
Authors: Aydin Orhan
Published: November 2023

Single-case experimental designs (SCEDs) have grown in popularity in the fields such as education, psychology, medicine, and rehabilitation. Although SCEDs are valid experimental designs for determining evidence-based practices, they encounter some challenges in analyses of data. One of these challenges, missing data, is likely to be occurred frequently in SCEDs research due to repeated measurements over time. Since missing data is a critical factor that can weaken the validity and generalizability of a study, it is important to determine the characteristics of missing data in SCEDs, which are especially conducted with a small number of participants. In this regard, this study aimed to describe missing data features in SCEDs studies in detail. To accomplish this goal, 465 published SCEDs studies within the recent 5 years in six journals were included in the investigation. The overall results showed that the prevalence of missing data among SCEDs articles in at least one phase, as at least one data point, was approximately 30%. In addition, the results indicated that the missing data rates were above 10% within most studies where missing data occurred. Although missing data is so common in SCEDs research, only a handful of studies (5%) have handled missing data; however, their methods are traditional. In analyzing SCEDs data, several methods are proposed considering missing data ratios in the literature. Therefore, missing data rates determined in this study results can shed light on the analyses of SCEDs data with proper methods by improving the validity and generalizability of study results.
Effects of Assistive Technology Instruction on Pre-Service Teachers: A Systematic Review
Authors: Park Jiyeon , Gremp Michelle , Ok Min Wook
Published: November 2023

Assistive technology (AT) is critical for students with disabilities to access and engage in the general education curriculum, but research has consistently reported a lack of AT knowledge among general and special education teachers. This synthesis reviewed the literature on AT instruction in teacher preparation programs. A total of 14 studies were selected using specific selection criteria. Findings indicated that after receiving AT instruction, pre-service teachers showed positive gains in self-reported AT skills/knowledge, assessed AT skills/knowledge, and attitudes/perspectives toward AT, regardless of modality, incorporated instructional methods, or measurement. Despite the promising effects of AT instruction, this synthesis highlights the scarcity of research in the realm of such instruction within teacher preparation programs and emphasizes the need for more robust research methodologies in this area.
Performative censorship: Why some free speech conflicts should be taken seriously but not literally
Authors: George Cherian
Published: November 2023

In some speech-related disputes, censors do not gauge their success by whether the challenged cultural product or practice has been suppressed in accordance with their explicit demands. This article proposes a theory of performative censorship that can help explain this paradox. Building on the concepts of expressive laws and symbolic crusades from legal studies and social movement studies respectively, performative censorship disputes are defined as contentious episodes in which demands for or against speech regulation are expressed partly for the broader objective of gaining recognition for a group’s way of life, dignity or status. Case studies of two highly contentious conflicts are offered: over Confederate statues in the United States and cartoons of Islam’s Prophet Mohammed. The case studies show that movements’ goals and tactics are neither uniform nor static, making them more complex but also presenting opportunities for de-escalation.
Cultural industry in the age of post-truth democracy
Authors: Brunkhorst Hauke
Published: November 2023

The truth potential of art is realized not only by great art (of educated elites) but also by the cultural industry that has become the art of the masses. Great art and cultural industry do not only contradict one another but often interpenetrate and overlap subversively. Especially in critical periods of crisis (and revolution) great art and cultural industry go together with political action. However, in more counterrevolutionary periods as nowadays post-truth democracy, Adorno's gloomiest interpretation of the cultural industry becomes topical again.
Focus on creating value: The 2023 business information review survey
Authors: Phillips Stephen
Published: November 2023

In its 32nd year, the Business Information Review Survey captures insights from conversations with leading information managers in the UK. The participants include information industry leaders from a range of sectors, including financial services, law, professional services, manufacturing, health and biomedical. The conversations took place in the first six months of 2023. They covered corporate structure, the operating environment, staffing trends, the impact of technology, content delivery, vendor and client engagement. Respondents were also invited to share their strategic priorities for the remainder of 2023 and 2024.
Localised intravascular coagulation complicating venous malformations: Clinical characterisation
Authors: Blaise Sophie , Soya Esaie , Nou Monira , Malloizel-Delaunay Julie , Thiel Hélène , Bisdorff-Bresson Annouk , Seinturier Christophe
Published: November 2023

Objective

The International Union of Phlebology recommends measuring at least D-dimer and fibrinogen levels in the diagnosis of extensive extra-truncular venous malformations, with a surface area of 10 cm2 or those which are deep, as well as prior to any interventional procedure. The aim of the study was to characterise venous malformations associated with a possible vascular complication.

Method

This study was an observational and multicentre study. The objective was to explore the presence of a possible coagulation disorder among patients with venous malformation. The primary endpoint was to characterise venous malformations with increased D-dimer levels.

Results

The majority of the 72 venous malformations were located in the trunk region, mostly in intramuscular or subcutaneous locations. There were 72 venous malformations with increased D-dimer levels including 3 with biological disseminated intravascular coagulation (elevated D-dimer and fibrinogen <1 g/L). The anticoagulant treatments administered were very heterogeneous in class and dosage, and at the end of the treatment, 17 elevated D-dimers were persistent, 9 venous malformations remained painful and 27 showed thrombotic regression.

Conclusion

Venous vascular malformations are probably underestimated and should probably be explored more systematically in terms of coagulation disorder regardless of size or symptomatology. The therapeutic recommendations to treat localised intravascular coagulation with low-molecular weight are not widely applied. Studies are needed, in particular to assess the role of oral anticoagulants in the management of coagulation disorder among patients with venous malformation.
FKBP5 associated CD8 T cell infiltration is a novel prognostic biomarker in luminal B breast cancer
Authors: Tong Fei , Lu Genlin , Zang Jie , Hao Dingji , Xu Wangjue , Chen Jida , Ding Qiong , Xiong Hanchu
Published: November 2023

Objective

To investigate the relationship between FKBP prolyl isomerase 5 ( FKBP5) gene expression and CD8 T cells in tumour progression and immunology of the luminal B subtype of breast cancer (LBBC) using bioinformatics analyses.

Methods

The Gene Expression Profiling Interactive Analysis 2, Human Protein Atlas and breast cancer gene-expression miner v4.5 databases were used for data mining and analysing FKBP5, its co-expressed genes and CD8 T cell-related markers. The Tumor IMmune Estimation Resource 2.0 database was used for analysing the correlation and prognosis of FKBP5 and CD8 T cell infiltration level in LBBC.

Results

Upregulated FKBP5 expression was correlated with improved survival in LBBC. Upregulated FKBP5-related CD8 T cell markers were also demonstrated to be significantly correlated with better survival in LBBC and might play a role in the biological activity of FKBP5.

Conclusion

These findings suggest that FKBP5 and its associated CD8 T cell infiltration are potential benign prognostic indicators for LBBC.
Cardiac angiosarcoma: a case report
Authors: Farzin Alireza Omidi , Nejad Shahrzad Shahrokhi
Published: November 2023

Angiosarcoma is the most invasive and malignant cardiac tumor and most commonly originates from the right atrium. Early diagnosis is essential, and echocardiography has an important role in diagnosis. This tumor grows aggressively, and metastases to other sites makes it difficult to control. Surgical treatment remains the best option for patients who do not respond to chemoradiotherapy. We herein report a case of a 17-year-old patient with cardiac angiosarcoma who presented with dyspnea, chest pain, dry cough, and fever. Although we considered the most probable diagnosis to be constrictive pericarditis, pathologic examination revealed a primary angiosarcoma originating from the pericardium. The patient underwent total pericardiectomy. However, despite receiving chemotherapy for 2 weeks postoperatively, she developed complications including leukopenia and eventually died of respiratory failure. Late diagnosis of angiosarcoma often occurs, resulting in progression to end-stage disease and a very poor prognosis. Therefore, a thorough understanding of this entity, knowledge of its pitfalls in management, and establishment of an accurate treatment guideline would help to develop a reliable and life-saving treatment approach for these patients.
Safety and efficacy of continuous intravenous labetalol for blood pressure control in neurosurgical patients
Authors: Noiphithak Raywat , Duangprasert Gahn , Sukhor Sasikan , Durongkaweroj Pichayaphong , Yindeedej Vich
Published: November 2023

Objectives

Current evidence supporting the use of continuous intravenous labetalol for blood pressure (BP) control in neurosurgical patients is limited. This study aims to assess the efficacy and safety of labetalol in neurosurgical patients and identify potential contributing factors to these outcomes.

Methods

We retrospectively reviewed the medical records of neurosurgical patients who received continuous labetalol infusion for BP control. Efficacy was assessed based on the time needed to achieve the target BP (systolic BP ≤ 140 mmHg or diastolic BP ≤ 90 mmHg). Safety was assessed according to adverse events that occurred during labetalol administration. Factors associated with efficacy and safety were analyzed using a logistic regression model.

Results

Among 79 patients enrolled in this study, 47 (59.49%) achieved the target BP within 1 hour (early response). No factors were significantly associated with an early response. Hypotension was observed in 11 patients (13.9%), and bradycardia was observed in 8 patients (10.1%). Hypotension was significantly associated with patient age and motor impairment, while bradycardia was significantly associated with diabetes mellitus.

Conclusion

The efficacy and safety profiles of labetalol infusion suggest this treatment as a promising option for BP control in neurosurgical patients.
Advance Care Planning: A Story of Trust Within the Family
Authors: Iunius Lory A. , Vilpert Sarah , Meier Clément , Jox Ralf J. , Borasio Gian Domenico , Maurer Jürgen
Published: November 2023

As the family usually plays a central role at the end of life, the quality of family relationships may influence how individuals approach advance care planning (ACP). Our study investigates the associations of trust in relatives with regard to end-of-life (EOL) issues—used as a proxy measure of family relationship quality—with individuals’ engagement in EOL discussions, advance directive (AD) awareness, approval and completion, and designation of a healthcare proxy. Using nationally representative data of adults aged 55 years and over from wave 6 (2015) of the Survey of Health, Ageing, and Retirement in Europe (SHARE) in Switzerland ( n = 1911), we show that complete trust in relatives is related to higher engagement in ACP. Subject to patient consent, the family should, therefore, be included in the ACP process, as such practice could enhance patient-centered EOL care and quality of life at the end of life.
Temporal Patterns of Behavioral and Psychological Symptoms of Dementia and Caregiver Distress: Associated Daily and Individual Factors
Authors: Connelly Caitlin , Kim Kyungmin , Liu Yin , Zarit Steven H.
Published: November 2023

This study examined daily occurrences of behavioral and psychological symptoms of dementia (BPSD) and whether caregivers’ perceived distress towards BPSD varies throughout four phases of the day (i.e., morning, daytime, evening, and night). Family caregivers residing with relatives who were using adult day services (ADS) participated in an 8-day daily diary study (caregiver N = 173; caregiver-day N = 1,359). BPSD occurred most frequently in the evenings. ADS use, sleep disturbances, and dementia severity were significantly associated with BPSD occurrence for some phases of the day. Caregivers’ distress towards BPSD occurrences increased throughout the day (i.e., most stressful at night). However, caregivers showed lower reactivity to BPSD at night on days when their relatives used ADS. Evidence of temporal patterns of BPSD in community-dwelling older adults and caregiver distress demonstrated the importance of ADS use for BPSD reactivity and identified potential target windows and associated contextual factors for individualized interventions.
A preliminary study on the fire suppression efficacy of a prototype system on hydrocarbon-based diffusion flames
Authors: Joseph Paul , Arun Malavika , Moinuddin Khalid
Published: November 2023

We have investigated the use of a novel dual-stage firefighting strategy, where an inert gas is deployed as a carrier agent to discharge foamed water, obtained by mixing environmentally friendly surface-active agents. Here we also report specifically on some in-house built practical strategies. With a view to gauging the relative fire suppression efficacies of the selected agents, each one was discharged as a fine spray onto fires involving hexane, and also optionally where a typical Li-ion battery electrolyte acted as the fuel. In summary, it can be inferred that the air- or nitrogen-detergent formulations showed enhanced fire suppression attributes, in small-scale experiments, as compared with the aqueous medium alone. Furthermore, in almost all cases, the fire extinction property can be attributed mainly to the physical phenomena, produced by the flow of the inert gas, or air and enhanced wettability of the medium. Given that the fire tests were done at a relatively small scale, no definite conclusions can be drawn than those provided above; however, this study warrants further investigation, especially, at a larger scale.