bluuebunny/crossref_metadata_2025 huggingface dataset:
Tanda-Tanda Besar Kiamat: Analisis Metode Dan Kronologi
Authors: Mohd Rapingi Abdul Muhaimin , Ismail Mohd Yusuf
Published: June 2022

The emergence of various interpretations relating the current situation to the content of hadith al-fitan wa al-malahim has become a phenomenon among the public and experts in the field. Discussion among the public regarding this matter has gone viral whenever new issues ranging from politics, social, economic as well as cosmology, and medical issues appear to have a connection with certain hadith of the Prophet. However, discussion without a proper understanding of the methodology in dealing with hadith of al-fitan wa al-malahim could lead to a serious misunderstanding of the hadith. Besides, some people tend to create predictions of the time of al-Qiyamahbasede on their understanding of current issues and the hadith. This paper attempt to briefly describe the basic methodology in dealing with the hadith of al-fitan wa al-malahim, and further elaborate the chronology of major sign of the al-Qiyamah where correct understanding of the major events of al-Qiyamah could help in avoiding false prediction of the time of al-Qiyamah.
Wybrane problemy związane z przeprowadzeniem wyborów samorządowych w toku kadencji w czasie pandemii wirusa SARS-CoV-2 w Polsce
Authors: Pyrzyńska Agata
Published: June 2022

Celem opracowania jest analiza problematyki wyborów uzupełniających i przedterminowych przypadających w czasie trwania pandemii COVID-19 w Polsce. Rozważaniom poddano w szczególności charakter takich wyborów. Liczne ograniczenia, w tym chociażby w zakresie przemieszczania się czy gromadzenia, nie pozostawały bez wpływu na przebieg i realizację zasadniczych funkcji wyborów. Celem analizy jest także określenie, czy w świetle obowiązujących przepisów dopuszczalna jest zmiana terminu głosowania w zarządzonych wyborach samorządowych przypadających w trakcie trwania pandemii COVID-19. Odnotować bowiem należy, że w okresie od marca do kwietnia 2020 r., a następnie od listopada 2020 r. do czerwca 2021 r. praktyka ta stała się niemal powszechna. Rozstrzygnięcie tego problemu ma istotne znaczenie, gdyż każdy akt zarządzający wybory ze swej istoty powinien stanowić gwarancję przeprowadzenia wyborów w ściśle określonych ramach czasowych, przy zachowaniu terminów wynikających z kalendarza wyborczego, a nadto - każde działanie organu powinno znajdować oparcie w przepisach prawa. Występująca w czasie pandemii praktyka prolongowania terminu głosowania w wyborach lokalnych osłabiła tak rozumiany - gwarancyjny - charakter czynności zarządzenia wyborów, inspirując jednocześnie do dyskusji nad prawną dopuszczalnością takich działań. W artykule wykorzystano metodę formalnoprawną oraz dokonano analizy dorobku doktryny i judykatury.
СУБ’ЄКТИ ТА ПРИНЦИПИ МІЖНАРОДНОГО МОРСЬКОГО ПРАВА
Authors: Тимощук О.М. , Майданевич С.Б.
Published: June 2022

Сучасні реалії розвитку людства з новою силою актуалізують необхідність збереження природних ресурсів, зокрема, Світового океану. Морська діяльність завжди виступала одним з найважливіших чинників економічного зростання та забезпечення національної безпеки будь-якої країни. Для запобігання загострення міжнародної конфронтації та регулювання відносин між суб’єктами права щодо використання окремих морських територій в комерційних та некомерційних цілях були затверджені правові норми, які формувалися впродовж багатьох століть. Вироблена система правил Міжнародного морського права спрямована на охорону та збереження морського простору та його ресурсів, забезпечення рівного та вільного доступу до багатств Світового океану всім суб’єктам правовідносин незалежно від рівня їх соціально-економічного розвитку. Становлення України як міцної морської держави зумовлює необхідність у вихованні висококваліфікованих спеціалістів в галузі морської справи, які компетентні в питаннях Міжнародного морського права, основних правах і обов’язках його суб’єктів, а також принципах міжнародного законодавства в галуззі мореплавства. Все вищевказане зумовлює актуальність окресленої теми дослідження. В статті визначено сутність поняття «Міжнародне морське право», вказані його види, суб’єкти, правова доктрина формування та принципи. Встановлено, що відносини між основними учасниками (суб’єктами) морської справи регулюються як загальноприйнятими принципами Міжнародного права, так і спеціальними (галузевими), які виникли внаслідок практичної діяльності суб’єктів права на просторах Світового океану. Відображена концепція контролю та координації міжнародних відносин в морській справі, яка базується на системі принципів, закріплених міжнародними договорами. Вказано, що головними суб’єктами правовідносин в морській галуззі виступають держави та міжнародні організації. Зазначено, що визначені міжнародним законодавством принципи спрямованні на збереження суверенітету, територіальної цілісності кожної держави, мирне вирішення конфліктів між учасниками міжнародних відносин, їх співробітництво та виконання зобов’язань перед світовою громадськістю, дотримання прав і свобод людини, повагу до культурної самобутності кожного народу, раціональне використання, захист та охорону морського середовища тощо. Ключові слова: Міжнародне морське право, морський простір, суб’єкт права, принцип.
RESPUESTAS EDUCATIVAS PARA ALTAS CAPACIDADES, SEGÚN EL MODELO DE ENRIQUECIMIENTO ESCOLAR TIPO III DE RENZULLI: ESTUDIO DE CASO EN EDUCACIÓN INICIAL
Authors: Seade-Mejía Carolina , Arízaga-Larrea Ma. Paz , Placencio-Ruiz Paulina , Vélez-Calvo Ximena
Published: June 2022

Algunas investigaciones previas han mostrado efectividad en la aplicación de respuestas educativas a niños con altas capacidades. El objetivo de esta investigación fue diseñar, aplicar y evaluar, por medio de la educación en línea, un programa para un niño de cinco años con altas capacidades, utilizando el Modelo de Enriquecimiento Escolar tipo III según Renzulli, además de medir la efectividad de la intervención. Por medio de la plataforma zoom, se entrevistó a padres y docentes y se aplicó un Proyecto de Enriquecimiento tipo III, según el modelo de Renzulli. Finalmente se evaluaron los resultados del trabajo. El niño demostró, durante y después de la implementacióndel programa, una valiosa motivación por aprender y se pudo observar que se potenciaron los intereses detectados por este modelo y las destrezas. Esta intervención fue exitosa a pesar de que se llevó a cabo durante la etapa de confnamiento de la pandemiapor COVID-19.

Palabras claveModelo de enriquecimiento, aprendizaje basado en proyectos, altas capacidades, estudio de caso, educación inicial.

AbstractPrevious research has shown efectiveness in the application of educational responses to gifted children. The objective of this research was to design, apply and evaluate, through online education, a program for a fve-year-old gifted child by using the Type III School Enrichment Model according to Renzull in addition to measuring the efectiveness of the intervention.Through the zoom platform, parents and teachers were interviewed and a type III Enrichment Project was applied according to the Renzulli model. Finally, the results of the work were evaluated. The child demonstrated during and after the implementation of the program a valuable motivation to learn and it was observed that the interests detected by this model and the skills were enhanced. This intervention was successful despite the fact that it was carried out during the confnement stage of the COVID-19 pandemic.

KeywordsEnrichment model, project based learning, high capacities, case study, initial education.
PERBANDINGAN BIAYA DAN WAKTU PEMAKAIAN ALAT BERAT BULLDOZER DAN EXCAVATOR DIBANDINGKAN DENGAN BACKHOE LOADER PADA PEMBANGUNAN PETERNAKAN AYAM DAYEUH MANGGUNG
Authors: Sopa Robby Maulana , Permana Sulwan , Farida Ida
Published: June 2022

Pembangunan Peternakan Ayam Dayeuh Manggung terletak di Kampung Warukai DesaDayeuh Manggung Kecamatan Cilawu Kabupaten Garut. Luas lahan yang akan dibangun Â± 200 Ha,Penggunaan alat berat pada Pembangunan Peternakan Ayam Dayeuh Manggung ini yaitu alat beratyang sering dipakai dalam pelaksanaan gali timbun antara lain: bulldozer, excavator, backhoe loaderdan truk. Penelitian ini berupa analisis perbandingan pemakaian kombinasi alat berat bulldozer danexcavator dibandingkan dengan pemakaian backhoe loader untuk Â pekerjaan galian dan timbunan/pemindahan material, permodelan Â penggunaan alat berat dilakukan dalam tinjauan biayadan waktu pekerjaan kemudian membandingkan hasil analisis perhitungan tersebut. Dari hasilanalisis perhitungan, maka waktu yang diperlukan oleh kombinasi excavator dengan bulldozerÂ sebesar 2089,86 jam, sedangkan Â waktu Â untuk backhoe loader sebesar 2835,48 jam. Maka waktutercepat dengan menggunakan kombinasi antara excavator dengan bulldozer dengan selisih waktu745,62 jam. Berdasarkan perbandingan biaya pelaksanaan pekerjaan, waktu yang diperlukan olehkombinasi excavator dengan bulldozer sebesar Rp.981.294.412,00- sedangkan biaya untuk backhoeloader sebesar Rp. 897.394.401,00- Â Maka Â biaya termurah Â dengan Â menggunakan backhoe loaderdengan selisih biaya Rp. 83.900.012,00-. Untuk pekerjaan perataan tanah sebaiknya menggunakankombinasi excavator dengan bulldozer karena lebih efisien dari segi waktu, Namun Â bila Â meninjauÂ dari Â segi biaya Â atau Â penghematan Â maka Â disarankan menggunakan backhoe loader.
Pengaruh Curah Hujan Harian terhadap Ketersediaan Air pada Perencanaan Pembangunan Pembangkit Listrik Tenaga Minihidro (PLTM) Sungai Cisanggiri Kecamatan Cihurip Kabupaten Garut
Authors: Mulyana Widya Prima , Permana Sulwan , Farida Ida
Published: June 2022

Hidrologi didefinisikan sebagai ilmu yang mempelajari sistem kejadian air di atas, pada permukaan dan di dalam tanah untuk mendapat nilai aliran di sungai. Data-data yang diperlukan dalam perencanaan hidrologi adalah: curah hujan harian, luas daerah aliran sungai, serta perbedaan ketinggian antara wilayah satu dengan wilayah lainnya. Dari data-data tersebut akan diperoleh curah hujan harian rata-rata, curah hujan minimum, curah hujan maksimun, standar deviasi, koefisien variasi, koefisien kemencengan, koefisien kurtosius, sebaran normal, sebaran gumbel, debit yang menggunakan rumus rasional, intensitas hujan, serta debit andalan. Selanjutnya dengan debit andalan tersebut kita dapat menghitung seberapa besar enegri listrik yang berasal dari tenaga air. Energi listrik itu diperoleh dari perhitungan debit dikali dengan beda ketinggian yang akan dijadikan sebagai terjunan air dan dikalikan dengan gravitasi bumi. Hasil analisis itu adalah energi listrik kotor karena belum memasukan efisiensi hidrolik yang berasal dari turbin, generator, serta transmisi mekanik. Dalam penelitian ini penulis tidak menghitung energi bersih yang dihasilkan oleh pembangkit karena hal itu diluar dari ruang lingkup teknik sipil yaitu hidrologi.
ANALISA SAMBUNGAN BATANG TARIK STRUKTUR BAJA DENGAN METODE ASD DAN METODE LRFD
Authors: Azhari Ghinan
Published: June 2022

Analisa ini memberikan penjelasan mengenai sambungan batang tarik dengan berdasarkan metode tegangan kerja (Allowable Stress Design, ASD) dan berdasarkan metode beban terfaktor (Load and Resistance Factor Design, LRFD). Metode ASD dalam perencanaan struktur baja telah cukup lama digunakan, namun beberapa tahun terakhir metode desain dalam struktur baja mulai beralih ke metode lain yang lebih rasional, yakni metode LRFD. Metode ini didasarkan pada ilmu probabilitas, sehingga dapat mengantisipasi segala ketidakpastian dari material maupun beban. Oleh karena itu metode LRFD ini dianggap cukup andal. Metode LRFD untuk perencanaan struktur baja yang diatur dalam SNI 03-1729-2002, berdasarkan pada metode FOSM. Batang tarik umumnya terdapat pada struktur rangka batang, batang tarik ini sangat efektif dalam memikul beban. Batang ini dapat terdiri dari profil tunggal ataupun profil-profil tersusun. Dalam menentukan kekuatan nominal penampang suatu batang tarik, harus ditinjau terhadap tiga macam kondisi keruntuhan yang menentukan, yaitu kondisi leleh dari luas penampang kotor/bruto, di daerah yang jauh dari sambungan, kondisi fraktur/putus dari luas penampang efektif pada daerah sambungan, serta kondisi geser blok pada sambungan. Faktor tahanan komponen struktur yang memikul gaya tarik aksial harus kuat terhadap tarik leleh dan terhadap kuat tarik fraktur. Luas penampang netto batang tarik yang disambung dengan paku keling (rivet) atau baut (bolt) harus dilubangi. Ini mengakibatkan berkurangnya luas penampang yang dibutuhkan untuk memikul gaya tarik, sehingga kekuatan tarik batang akan berkurang, SNI 03-1729-2002 menyebutkan dalam suatu potongan jumlah luas lubang tidak boleh melebihi 15% luas penampang utuh. Dalam metode LRFD untuk menentukan kekuatan nominal penampang suatu batang tarik, harus ditinjau terhadap tiga macam kondisi keruntuhan yang menentukan dari kondisi leleh geser dari luas penampang kotor/bruto, kondisi fraktur/putus dari luas penampang efektif pada daerah sambungan, kondisi geser blok pada sambungan dan dari ketiga kondisi keruntuhan tersebut diambil nilai terkecil yaitu 114 kN. Untuk metode ASD kekuatan batang tarik pada beban maksimum yang dapat dipikul kurang dari 6,3 ton, dan untuk pembebanan sementara kurang dari 8,2 ton.
Pelatihan Koperasi Go-Digital
Authors: Juliharta I Gede Putu Krisna , Astawa Ni Luh Putu Ning Septyarini Putri
Published: June 2022

Pada abad ke-21 ini, perkembangan ilmu pengetahuan teknologi dan komunikasi sangat pesat, termasuk di antaranya adalah koperasi. Koperasi adalah sebuah organisasi ekonomi yang dimiliki dan dioperasikan oleh orang-seorang demi kepentingan bersama dengan tujuan mewujudkan dan mengembangkan perekonomian nasional yang merupakan usaha berdasarkan asas kekeluargaan dan demokrasi ekonomi. Pada masa pandemi covid-19 seperti sekarang ini banyak kegiatan dan interaksi masyarakat yang dibatasi demi untuk mengurangi penyebaran virus, sehingga mau tidak mau segala jenis aspek dalam berkehidupan dipaksa untuk online atau Go Digital. Bagaimana sebuah koperasi bisa melihat keuntungan dari digitalisasi usaha koperasi itu sendiri? Maka dari permasalahan tersebut, penulis mengadakan kegiatan Pelatihan Koperasi Go Digital ini. Kegiatan pelatihan untuk pengurus koperasi se-kota Denpasar tersebut berlangsung pada bulan November  2020.  Sekitar 100% dari jumlah peserta 35 orang hadir mengikuti kegiatan. Dapat disimpulkan dari hasil observasi yang dilakukan, tingkat keaktifan peserta tinggi sehingga dapat disimpulkan kegiatan berlangsung dengan baik.
PENGARUH KOMPRES HANGAT TERHADAP PENURUNAN NYERI HAID (DISMENORE) PADA MAHASISWI PROGRAM STUDI D III KEPERAWATAN FMIPA UNIVERSITAS BENGKULU
Authors: Delfina Rina , Saleha Nurmukaromatis , Sardaniah Sardaniah
Published: June 2022

Metode mengurangi rasa nyeri pada saat haid yang sering digunakan saat ini adalah penggunaan obat-obatan (farmakologis), metode ini memang dengan cepat mengurangi rasa nyeri, tapi dampak jangka panjang penggunaan obat dapat menimbulkan permasalahan pada beberapa organ tubuh. Penelitian ini menawarkan metode alternatif dalam mengurangi rasa nyeri pada saat haid dengan cara non-farmakologis yaitu dengan cara kompres hangat. Tujuan dari penelitian ini adalah untuk melihat adanya pengaruh kompres air hangat terhadap penurunan rasa nyeri haid. Jenis penelitian adalah pra Eksperimental dengan desain one group pretest-postest. Sampel diambil secara total sampling sebanyak 30 sample. Analisis data dilakukan secara Univariat dan Bivariat dengan uji Paired t-test pada  ?5%. Hasil penelitian menunjukkan ada penurunan rata-rata nyeri haid sesudah dibandingkan dengan sebelum dilakukan tindakan kompres hangat sebesar 2,533. Dapat disimpulkan ada pengaruh pemberian kompres hangat terhadap penurunan nyeri haid. Saran kompres hangat dapat dijadikan alternatif untuk mengurangi nyeri pada saat haid, sebagai salah satu metode non-farmakologis dalam mengatasi rasa nyeri.
Development of Machine Learning Models for Predicting Daylight Glare Probability
Authors: Yao Jian
Published: June 2022

This paper aims to develop DGP predictive methods. Linear regression and machine learning based approaches were used to compare the performance of newly developed models and these models were compared with existing equations. The results show that developed models are more correct in predicting DGP than the existing equation. In addition, the second new finding by this research is that the combination of the azimuth (Az) and altitude (Aa) angle of the sun and time of day (T) along with vertical eye illuminance (Ev) supply a little better performance than Ev alone due to the consideration of the interaction effect between these factors. Therefore, the developed models can be used if linear model is preferred for simplification of computation. For a higher predictive performance, random forest models based on Ev, Az, Aa, and T is recommended due to its capability of dealing with nonlinear effects. The last contribution of this paper is that a classification model was developed for predicting DGP>0.4 by random forest algorithm considering Ev, Az, Aa, and T with adequate accuracy (90 %), which extends the ability of existing methods to the condition when the sun is in the field of view.
Avaliação do impacto ambiental de um curtume
Authors: Monteiro Antônio Oliveira , Figueiredo Caio Franklin Vieira de , Sousa Glaucio de Meneses , Formiga Aliane Cristiane de Sousa , Oliveira Francisco Fabrício Damião de , Oliveira Pierre Alexandre Travasso de , Nascimento Raiff Ramos Almeida , Leite Ana Carolina Nóbrega , Leite José Cleidimário Araújo
Published: June 2022

O objetivo com essa pesquisa é classificar os potenciais impactos ambientais resultantes de empreendimentos de curtumes e sugerir medidas de controle ambiental para tais impactos. A metodologia utilizada consistiu em levantamentos e estudos bibliográficos, através de leituras de artigos científicos, livros, manuais (Manual de Impactos Ambientais do Banco do Nordeste), Relatórios e Estudos de Impacto Ambiental, tendo a finalidade de coletar informações necessárias para a identificação e classificação dos impactos ambientais resultantes da implantação de curtumes. Torna-se evidente que os impactos ambientais significativos, sejam eles positivos ou negativos, resultantes de todas as atividades realizadas em todas as etapas de um projeto de um determinado empreendimento, devem ser estudados, com a finalidade de se avaliar a viabilidade ambiental para a implantação do projeto. A fase de planejamento não apresenta impactos ambientais significativos e que os impactos ambientais significativos são mais observados na fase de implantação do empreendimento. Os fatores ambientais: solo e recursos hídricos, bem como os fatores bióticos fauna e flora apresentaram uma grande quantidade de impactos significativos negativos. Dos 38 impactos identificados, 32 foram considerados significativos, destes 29 foram considerados negativos, 3 foram considerados positivos e 6 foram considerados não significativos.
Fratura por avulsão associada a desmite do ligamento sesamoideano reto em uma égua: diagnóstico, tratamento e prognóstico
Authors: Silveira Bruno Belmonte , De Bastiani Grasiela , Icarte Renato Duarte , Azevedo Marcos da Silva , Jacobsen Tainã Kuwer
Published: June 2022

Lesões nos ligamentos sesamoideanos podem ocorrer em equinos praticantes de várias modalidades, sendo os cavalos de corrida os mais propensos a alterações nestas estruturas. Além do exame clínico, as imagens ultrassonográficas e radiográficas podem ser utilizadas para o diagnóstico de possíveis alterações nos ligamentos sesamoideanos e estruturas ósseas. O propósito deste estudo foi relatar os achados clínicos, radiográficos e ultrassonográficos, bem como a terapia e desfecho de um caso de desmite do ligamento sesamoideano reto associado à fratura por avulsão em um equino. Uma égua, Quarto de Milha, 5 anos, 450 kg, apresentou subitamente um quadro de claudicação severa do membro torácico direito. O animal apresentava claudicação grau 4/5 (AAEP), aumento de temperatura e dor a palpação no aspecto palmar da quartela. Ao exame radiográfico, identificou-se leve irregularidade no aspecto palmaroproximal da falange intermédia e uma área de reabsorção óssea associado a irregularidade na tuberosidade flexora da falange intermédia. Na avaliação ultrassonográfica da região palmar da quartela, observou-se a presença de áreas de irregularidade na inserção do scutum médio associado a presença de fragmentos ósseos na tuberosidade flexora da falange intermédia, bem como aumento de tamanho do ligamento reto e áreas de ruptura de fibras. Indicou-se a utilização de de fenilbutazona e repouso por quatro meses. Quando reavaliada, após dois meses, a égua apresentou claudicação grau 2/5 (AAEP), sem resposta positiva a palpação da quartela e a flexão forçada do dígito. No caso relatado, o exame clínico associado as imagens radiográficas e ultrassonográficas foram suficientes para determinação do diagnóstico final e posterior prescrição do tratamento adequado. A terapia instituída a base de anti-inflamatório não esteroidal e repouso mostrou-se eficaz na redução dos sinais clínicos.
Study of drying kinetics in ceramic plates with the addition of diatomite tailings
Authors: Costa Raniere Fernandes , Ferreira Alysson Dantas , Nascimento José Jefferson da Silva , Rezende Maria Luiza de Souza , Silva Junior José Jorge da , Vieira Antônio Nunes de Oliveira
Published: June 2022

The drying process of ceramic bricks plays a key role in the amount of water available both inside the material and on its surface. This work aimed to analyze drying kinetics on ceramic tiles with different percentages of diatomite tailings, which was experimentally carried out in an oven with forced air circulation. To this end, laboratory tests were performed using different samples in which the drying kinetics was evaluated considering different environmental conditions (temperature and relative humidity), based on a 2k factorial experimental design with three factors: the drying temperatures (333 and 383 K), the homogeneity of the mixture (30 and 60 min) and the percentage of the tailings (10 and 30%). From the results matrix, some models of drying kinetics were adjusted to the experimental data, having the Page model presented the best result. Still in possession of the results matrix, a regression model was applied to obtain equations that describe Page's fit parameters. The drying curves developed from the estimated parameters, presented a significant agreement with the experimental data, being validated within a 99% confidence interval.
Electrical parameters of transcranial direct current stimulation that effectively alter cerebral blood flow in experimental animals: a systematic review
Authors: Almeida Camila Carolinne Silva de , Valença Marcelo Moraes , Rosas Emanuela Paz , Montenegro Eduardo José Nepomuceno , Alves Laura Izabel do Nascimento , Wanderley Débora , Tenório Angélica da Silva , Oliveira Daniella Araújo de
Published: June 2022

Objective: To identify the electrical parameters of transcranial direct current stimulation (tDCS) that effectively alter cerebral blood flow in rats. Methodology: Six eletronic databases were searched with no time or language restrictions to identify experimental studies with rats using tDCS with anodal and/or cathodal stimulation with or without a comparison group. Internal validity was assessed via the following criteria: housing, lighting, temperature, water/food, groups randomization and ethical aspects. The ‘Laboratory Systematic Review Center for Laboratory animal Experimentation’ (SYRCLE) tool was used to assess risk of bias. The tDCS electrical parameters and cerebral blood flow were considered as primary outcomes and cerebral histological alterations as the secondary outcome. Results: Four articles were included. All four studies were considered to present a high level of scientific bias. The electrical tDCS parameters implemented were heterogeneous but overall, tDCS with anodal stimulation promoted an increase in cerebral blood flow while the cathodal stimulation decreased it. Cerebral histological alterations were assessed in two studies and tissue necrosis was reported in only one animal per study. Conclusion: The identification of tDCS electrical parameters that effectively alter cerebral blood flow in rats was not possible due to the heterogeneity of tDCS protocols being implemented in the literature. Considering the high risk of scientific bias in the included studies, the current available evidence regarding tDCS efficacy is insufficient and inconclusive.
Experimental cauda equina compression induces HSP70 synthesis in dog.
Authors: Čížková D , Lukáčová N , Maršala M , Kafka J , Lukáč I , Jergová S , Čížek M , Maršala J
Published: June 2022

The heat shock protein 70 (HSP70) is a key component of the stress response induced by various noxious conditions such as heat, oxygen stress, trauma and infection. In present study we have assessed the consequences of the compression of lower lumbar and sacral nerve roots caused by a multiple cauda equina constrictions (MCEC) on HSP70 immunoreactivity (HSP70-IR) in the dog. Our data indicate that constriction of central processes evokes HSP70 up-regulation in the spinal cord (L7, S1-Co3) as well as in the corresponding dorsal root ganglion cells (DRGs) (L7-S1) two days following injury. A limited number of bipolar or triangular HSP-IR neurons were found in the lateral collateral pathway (LCP) as well as in the pericentral region (lamina X) of the spinal cord. In contrast, a high number of HSP70 exhibiting motoneurons with fine processes appeared in the ventral horn (laminae VIII-IX) of lumbosacral segments. Concomitantly, close to them a few lightly HSP70-positive neuronal somata or cell bodies lacking the HSP70-IR occurred. In the DRGs, HSP70 expression was mildly up-regulated in small and medium-sized neurons and in satellite cells. On the contrary, DRGs from intact or sham-operated dogs did not reveal HSP70 specific neuronal staining. In conclusion, we have demonstrated that the MCEC in dogs mimicking the cauda equina syndrome in clinical settings evokes expression of HSP70 synthesis in specific neurons of the lumbo-sacro-coccygeal spinal cord segments and in small and medium sized neurons of corresponding DRGs. This suggests that HSP70 may play an active role in neuroprotective processes partly by maintaining intracellular protein integrity and preventing the neuronal degeneration in this experimental paradigm.
DEVELOPMENT OF MATHEMATICS LEARNING DEVISES ON DISCOVERY LEARNING MODEL ON SQUARE AND TRIANGLE MATERIAL FOR THE SEVENTH GRADE STUDENT OF JUNIOR HIGH SCHOOL
Authors: Faniyanti Meiana , Syofni  , Sakur
Published: June 2022

This research is motivated by the limited mathematics learning tools that are in accordance with the 2013 curriculum. The aim of this research is to produce learning tools in the form of a syllabus, lesson plans (RPP), and student activity sheets (LAS) using discovery learning models in the material of class VII quarters and triangles. SMP / MTs. The development model used in this study is the 4-D model which consists of four stages of development, namely defining, designing, developing, and distributing. Data collection using practical instruments. The learning tools that have been developed are validated by three expert validators. The findings of the study revealed that the results of the syllabus validation analysis were 3.79 or very valid categories, RPP were 3,87 or very valid categories and LAS were 3.82 or very valid categories. The results of this validation analysis indicate that the syllabus, lesson plans, and LAS are considered valid. Furthermore, the results of the practicality trial in the small group for LAS were 3.50 or very practical category. The conclusion of this study is that the mathematics learning tools developed using the discovery learning model in the material of Quadrilateral and Triangles of class VII SMP / MTs which include syllabus, lesson plans and LAS are valid and feasible to use.
THE EFFECT OF APPLICATION OF SEARCH, SOLVE, CREATE, AND SHARE (SSCS) LEARNING MODEL ON STUDENTS' MATHEMATICS COMMUNICATION ABILITY BASED ON PREVIOUS KNOWLEDGE IN MATHEMATICS IN JUNIOR HIGH SCHOOL
Authors: Sahrul Hidayat  , Nufus Hayatun , Muhandaz Ramon
Published: June 2022

This study aims to determine whether there are differences in mathematical communication skills between students who are taught by the Search, Solve, Create, and Share (SSCS) learning model and students who are taught using conventional learning; find out whether or not there is a difference in the mathematical communication skills of students who have high, medium, and low prior knowledge of mathematics; and see whether or not there is an interaction between students' prior knowledge in mathematics and the SSCS learning model on students' mathematical communication skills. This research is a quasi-experimental study with a posttest-only control group design. The population in this study were all seventh grade students of SMP Negeri 3 Tambang for the 2019/2020 academic year. The sample in this study was class VII.1 as the experimental class and class VII.3 as the control class which was selected by simple random sampling. The data was collected by using a test technique in the form of a mathematical communication ability test instrument and PAM test questions. Analysis of the data used for hypotheses 1, 2 and 3 using a two-way ANOVA test. The results of data analysis show that there are differences in mathematical communication skills between students who follow the SSCS learning model and students who follow conventional learning. there are differences in mathematical communication skills between students who have high, medium and low PAM, and there is no interaction of PAM factors on mathematical communication skills. students at SMP Negeri 3 Tambang.
Cover dan Daftar Isi Vol 4 No 1 (2021)
Authors: Jurnal Prinsip Pendidikan Matematika
Published: June 2022

Cover dan Daftar Isi Vol 4 No 1 (2021)
ANALYSIS OF STUDENTS’ DIFFICULTIES IN SOLVING STORY PROBLEMS ON LINEAR PROGRAMMING MATERIAL AT SMAN 3 SIDRAP
Authors: Tiara  , Usman  , Ahsan Muhammad
Published: June 2022

This study aims to describe students' difficulties in solving story problems on linear programming material, the factors that cause students' difficulties in solving story problems, and how to overcome students' difficulties in solving story problems on linear programming material at SMAN 3 SIDRAP. This type of research is descriptive qualitative, with the research subject being class XI IPS 2 SMAN 3 SIDRAP, totalling ten students. Based on the results of the research, the difficulties experienced by students in solving story problems on linear programming material are conceptual difficulties, principle difficulties, information difficulties and arithmetic difficulties. Factors causing difficulties are divided into external factors, including the family and school environment and internal factors, including the lack of student interest in learning mathematics, especially in linear programming material, study routines, and lack of motivation to learn. Efforts were made to overcome these difficulties, namely providing a good understanding to students, making students active in asking questions and using learning media.
DEVELOPING LEARNING INSTRUMENTS BASED ON EXPERIENTIAL LEARNING MODEL ON SUBJECT OF CIRCLE FOR 8th GRADE STUDENTS OF JUNIOR HIGH SCHOOL
Authors: Mihardi Anggi , Solfitri Titi
Published: June 2022

The purpose of this research is to develop the mathematics learning instrument: syllabus, lesson plans (RPP), and student worksheets (LKPD) using the experiential learning model on circle subject for 8th grade students of junior high school (SMP) that is categorized as valid and categorized as practical. This research used Research and Development (R&D) model with ADDIE procedure; analyze, design, development, implementation, and evaluation. The research instruments used in this research were learning instrument validation sheets and student response questionnaires. The syllabus, RPP, and LKPD were validated by three validators and revised according to suggestions from the validator. The valid LKPD was then tested in two stages: the small and large groups. According to the validation data analysis of learning instruments, those were categorized as very valid, with the average score for syllabus being 4.24, for RPP was 4.18, and LKPD was 3,85. According to the result of student response questionnaires toward the LKPD practicality already the requirements of practicality with the percentage of students' response reaches 84% in large group trials. According to the result of data analysis and the discussion, it can be concluded that the learning instruments using the experiential learning model on circle subject were very valid, and the LKPD was very practical to be used by 8th grade students of junior high school.
DEVELOPMENT OF MATHEMATICS LEARNING DEVICES WITH PROBLEM BASED LEARNING (PBL) MODEL ON STATISTICS MATERIALS FOR SMP/MTs CLASS VIII
Authors: Sobriani Desti , Solfitri Titi
Published: June 2022

This study aims to produce mathematics learning tools in the form of a syllabus, lesson plans (RPP), and student worksheets (LKPD) based on a problem-based learning model on statistical material for class VIII junior high school students. This study uses a 4-D development model, which includes four stages, namely: (1) define; (2) design; (3) develop; and (4) dIsseminate. The research instrument used is the instrument of validity and practicality. The validity instrument is in the form of a validation sheet to assess the feasibility of the syllabus, lesson plans, and LKPD. The practical instrument is in the form of a student response questionnaire to the use of LKPD. The learning tools that have been compiled are then validated by three validators and revised according to suggestions from the validators. The valid learning tools were then tested in small groups with the subject of 6 students of class VIII SMP. Based on the results of data analysis and discussion, mathematics learning tools in the form of syllabus, lesson plans and LKPD with a problem-based learning model on statistical material are considered very valid and very practical to be used by junior high school students of class VIII.
Development of a Water Quality Index for Lake Aygır in Bitlis, Turkey
Authors: ÇAVUŞ Asude , ŞEN Fazıl
Published: June 2022

Water quality indices help to develop correct policies using water quality data. In this study, a useful and reliable method was determined for water quality management of Lake Aygır. For this, monthly water quality measurements were made from Lake Aygır between May 2015 and May 2016. Expert opinions and literature were used in the selection of parameters. Temperature, dissolved oxygen, electrical conductivity, pH, ammonia, alkalinity, hardness, fluorine, and arsenic parameters were selected for the calculation of the water quality index of Lake Aygır for drinking (AG-WQIdrinking), as it is more effective on human health. Temperature, dissolved oxygen, electrical conductivity, pH, ammonia, alkalinity, hardness, and turbidity were selected for the calculation of the water quality index of Lake Aygır for fisheries (AG-WQIfisheries) as they are the parameters to which fish is most affected. Water quality indices of Lake Aygır were found AG-WQIdrinking as 149.41 and AG-WQIfisheries as 76.11. The most effective parameters were hardness and alkalinity in the AG-WQIdrinking calculations; and ammonia and dissolved oxygen in the AG-WQIfisheries calculations. Hence, it expresses numerically the suitability of Lake Aygır in terms of drinking and fishing.
Spatio-Temporal Distribution of Aquatic Biodiversity in Gorai Creek, Sub-Urban Mumbai, India
Authors: CHANDRAN Sudhan , SINGH Sanjenbam Bidyasagar , SREEKANTH Giri Bhavan , DESHMUKHE Geetanjali , NAYAK Binay Bhusan , JAISWAR Ashok Kumar
Published: June 2022

This study was conducted to assess the faunal diversity in Gorai Creek of Mumbai, India from August 2019 to July 2020. The data collected month wise were pooled together and transformed into three seasons [Monsoon (June to September), Winter (October to February), and Summer (March to May)] and this seasonal data were used for the study of biodiversity pattern. Using the average seasonal species occurrence data as input the following biodiversity indices, S, N, d, J', H'(loge), 1-Lambda, Delta, Delta*, Delta+, sDelta+, Lambda+, Phi+ & sPhi+ were calculated by using PRIMER (v7.0). It revealed that 90 species of fauna under 70 genera, 50 families, 29 orders, 6 classes and 3 phyla were found to occur in the creek. The order-wise representation of identified fauna was found to be 7 ichthyofaunas, 4 pelecypods, 6 gastropods, 2 cephalopods, 1 shrimp and 1 stomatopod along with 8 avifauna. The present study results indicated that the Gorai Creek ecosystem is endowed with moderate biodiversity that needs to be conserved.
Transformations in the Translation of Hard and Soft News
Reports into Arabic
Authors: Sharkas Hala
Published: June 2022

This study examines local transformations as a translation strategy of the news
report genre from English into Arabic. It analyzes the frequency of deletion, substitution,
addition, and reorganization to identify any relation between applying these transformations
and news topics. This is achieved via a textual analysis of a parallel corpus of 60 texts of
hard and soft news reports in English and Arabic derived from two sources: the Reuters
(news agency) and BBC (news broadcaster) websites. Results show that deletion is by far
the most frequently used transformation in both soft and hard news. Transformation
frequencies are discussed in relation to the structural elements of news reports.
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Ling Ma’s Severance: A Dystopian Pre/Post-Apocalyptic Novel in the
Time of Covid-19
Authors: A. Helmy Soha
Published: June 2022

In her attempt to write an apocalyptic fictional story, Ling Ma succeeds in
creating an extraordinarily believable and engrossing anti-utopian image of the world. Her
debut, Severance (2018), transcends the dystopian apocalyptic genre and becomes an
impressive prophecy that partially comes true during the current Coronavirus crisis. It
announces her as a talented author with its mix of humor, anger, terror and satire. Ma
intends her book to be a critique of Capitalism. That is why she magnifies its harmful side
effects through the lens of a destructive illness that starts with flu-like symptoms and
develops into a pandemic. However, her book rings shocking and frighteningly true these
days with the widespread of Covid-19. This research examines Ma’s Severance from a
dystopian pre/post-apocalyptic perspective and highlights the similarities between its
events and what happens during the current Covid-19 pandemic. The analogy between both
pandemics proves that dystopian apocalyptic works are not always science fictional. First,
the research briefly traces the origin of dystopian apocalyptic literature. Then, it discusses
the use of common characteristics of this genre in the novel. Among them are the loss of
individualism, the spread of plagues and pandemics, totalitarianism, the regimented lives
of citizens, using the ‘defamiliarization’ technique, and emphasis on the theme of
survivorship..
The Potential of Brewer’s Spent Grain in the Circular Bioeconomy: State of the Art and Future Perspectives
Authors: Zeko-Pivač Anđela , Tišma Marina , Žnidaršič-Plazl Polona , Kulisic Biljana , Sakellaris George , Hao Jian , Planinić Mirela
Published: June 2022

Brewer’s spent grain (BSG) accounts for approximately 85% of the total mass of solid by-products in the brewing industry and represents an important secondary raw material of future biorefineries. Currently, the main application of BSG is limited to the feed and food industry. There is a strong need to develop sustainable pretreatment and fractionation processes to obtain BSG hydrolysates that enable efficient biotransformation into biofuels, biomaterials, or biochemicals. This paper aims to provide a comprehensive insight into the availability of BSG, chemical properties, and current and potential applications juxtaposed with the existing and emerging markets of the pyramid of bio-based products in the context of sustainable and circular bioeconomy. An economic evaluation of BSG for the production of highly valuable products is presented in the context of sustainable and circular bioeconomy targeting the market of Central and Eastern European countries (BIOEAST region).
Application of Metal-Based Nanozymes in Inflammatory Disease: A Review
Authors: Li Ruifeng , Hou Xinyue , Li Lingrui , Guo Jiancheng , Jiang Wei , Shang Wenjun
Published: June 2022

Reactive oxygen species (ROS) are metabolites of normal cells in organisms, and normal levels of ROS in cells are essential for maintaining cell signaling and other intracellular functions. However, excessive inflammation and ischemia-reperfusion can cause an imbalance of tissue redox balance, and oxidative stress occurs in a tissue, resulting in a large amount of ROS, causing direct tissue damage. The production of many diseases is associated with excess ROS, such as stroke, sepsis, Alzheimer’s disease, and Parkinson’s disease. With the rapid development of nanomedicine, nanomaterials have been widely used to effectively treat various inflammatory diseases due to their superior physical and chemical properties. In this review, we summarize the application of some representative metal-based nanozymes in inflammatory diseases. In addition, we discuss the application of various novel nanomaterials for different therapies and the prospects of using nanoparticles (NPs) as biomedical materials.
Maternal and Offspring Sugar Consumption Increases Perigonadal Adipose Tissue Hypertrophy and Negatively Affects the Testis Histological Organization in Adult Rats
Authors: Córdoba-Sosa Gabriela , Nicolás-Toledo Leticia , Cervantes-Rodríguez Margarita , Xelhuantzi-Arreguin Nicté , Arteaga-Castañeda María de Lourdes , Zambrano Elena , Cuevas-Romero Estela , Rodríguez-Antolín Jorge
Published: June 2022

Sugar intake has been associated with the development of male reproductive pathologies because of the increase and dysfunction in different adipose tissue depots. The establishment of these dysfunctions in the early stages of development is unknown. We evaluated the effect of maternal (pregnancy and lactation) and male offspring (from weaning to adulthood) consumption of 5% sucrose on perigonadal adipose tissue (PAT) and testis in adulthood. Moreover, two rat groups were compared, both including pregnant and lactating females: Control (C—drinking tap water) and sugar (S—consuming 5% sucrose solution). From weaning to adulthood with male offspring, four subgroups were formed: Control Mother → Control and Sugar offspring (CC, CS) and Sugar Mother → Control and Sugar offspring (SC, SS). At 120 postnatal days, the testes and PAT were collected and morphologically described. Furthermore, we quantified the number and cross-sectional area of perigonadal adipocytes and their distribution. We found that the males from SC and SS groups showed high PAT weight (p < 0.005), a high number (p < 0.05), and a relative frequency of large adipocytes (p < 0.05), establishing these results during gestational and lactation stages, and enhancing in adulthood since postnatal diet and its interaction. More macrophages, mast cells, and Leydig cells were observed in the interstitial space of the testis for the CS, SC, and SS groups, concluding that consumption of a high-carbohydrate maternal diet, program hypertrophy processes in adult PAT, developing and enhancing with sugar consumption during postnatal life. Furthermore, they are associated with inflammatory processes within the interstitial space of the testis.
MIR205HG/LEADR Long Noncoding RNA Binds to Primed Proximal Regulatory Regions in Prostate Basal Cells Through a Triplex- and Alu-Mediated Mechanism
Authors: Bezzecchi Eugenia , Pagani Giulia , Forte Barbara , Percio Stefano , Zaffaroni Nadia , Dolfini Diletta , Gandellini Paolo
Published: June 2022

Aside serving as host gene for miR-205, MIR205HG transcribes for a chromatin-associated long noncoding RNA (lncRNA) able to restrain the differentiation of prostate basal cells, thus being reannotated as LEADR (Long Epithelial Alu-interacting Differentiation-related RNA). We previously showed the presence of Alu sequences in the promoters of genes modulated upon MIR205HG/LEADR manipulation. Notably, an Alu element also spans the first and second exons of MIR205HG/LEADR, suggesting its possible involvement in target selection/binding. Here, we performed ChIRP-seq to map MIR205HG/LEADR chromatin occupancy at genome-wide level in prostate basal cells. Our results confirmed preferential binding to regions proximal to gene transcription start site (TSS). Moreover, enrichment of triplex-forming sequences was found upstream of MIR205HG/LEADR-bound genes, peaking at −1,500/−500 bp from TSS. Triplexes formed with one or two putative DNA binding sites within MIR205HG/LEADR sequence, located just upstream of the Alu element. Notably, triplex-forming regions of bound genes were themselves enriched in Alu elements. These data suggest, from one side, that triplex formation may be the prevalent mechanism by which MIR205HG/LEADR selects and physically interacts with target DNA, from the other that direct or protein-mediated Alu (RNA)/Alu (DNA) interaction may represent a further functional requirement. We also found that triplex-forming regions were enriched in specific histone modifications, including H3K4me1 in the absence of H3K27ac, H3K4me3 and H3K27me3, indicating that in prostate basal cells MIR205HG/LEADR may preferentially bind to primed proximal regulatory elements. This may underscore the need for basal cells to keep MIR205HG/LEADR target genes repressed but, at the same time, responsive to differentiation cues.
The Role of Lamins in the Nucleoplasmic Reticulum, a Pleiomorphic Organelle That Enhances Nucleo-Cytoplasmic Interplay
Authors: Stiekema Merel , Houben Frederik , Verheyen Fons , Borgers Marcel , Menzel Julia , Meschkat Martin , van Zandvoort Marc A. M. J. , Ramaekers Frans C. S. , Broers Jos L. V.
Published: June 2022

Invaginations of the nuclear membrane occur in different shapes, sizes, and compositions. Part of these pleiomorphic invaginations make up the nucleoplasmic reticulum (NR), while others are merely nuclear folds. We define the NR as tubular invaginations consisting of either both the inner and outer nuclear membrane, or only the inner nuclear membrane. Specifically, invaginations of both the inner and outer nuclear membrane are also called type II NR, while those of only the inner nuclear membrane are defined as type I NR. The formation and structure of the NR is determined by proteins associated to the nuclear membrane, which induce a high membrane curvature leading to tubular invaginations. Here we review and discuss the current knowledge of nuclear invaginations and the NR in particular. An increase in tubular invaginations of the nuclear envelope is associated with several pathologies, such as laminopathies, cancer, (reversible) heart failure, and Alzheimer’s disease. Furthermore, viruses can induce both type I and II NR. In laminopathies, the amount of A-type lamins throughout the nucleus is generally decreased or the organization of lamins or lamin-associated proteins is disturbed. Also, lamin overexpression or modulation of lamin farnesylation status impacts NR formation, confirming the importance of lamin processing in NR formation. Virus infections reorganize the nuclear laminavia(de)phosphorylation of lamins, leading to an uneven thickness of the nuclear lamina and in turn lobulation of the nuclear membrane and the formation of invaginations of the inner nuclear membrane. Since most studies on the NR have been performed with cell cultures, we present additional proof for the existence of these structuresin vivo, focusing on a variety of differentiated cardiovascular and hematopoietic cells. Furthermore, we substantiate the knowledge of the lamin composition of the NR by super-resolution images of the lamin A/C and B1 organization. Finally, we further highlight the essential role of lamins in NR formation by demonstrating that (over)expression of lamins can induce aberrant NR structures.