bluuebunny/crossref_metadata_2025 huggingface dataset:
A semi-automated virtual workflow solution for the design and production of intraoral molding plates using additive manufacturing: the first clinical results of a pilot-study
Authors: Grill Florian D. , Ritschl Lucas M. , Bauer Franz X. , Rau Andrea , Gau Dominik , Roth Maximilian , Eblenkamp Markus , Wolff Klaus-Dietrich , Loeffelbein Denys J.
Published: August 2018

Computer-aided design and computer-aided manufacturing (CAD/CAM) technology has been implemented in the treatment of cleft lip and palates (CLP) by several research groups. This pilot study presents a technique that combines intraoral molding with a semi-automated plate generation and 3D-printing. The clinical results of two intraoral molding approaches are compared. This is the first clinical investigation of semi-automated intraoral molding. Our study included newborns with unilateral CLP. Plaster models were digitalized and measured by two independent observers. Two methods of CAD/CAM-assisted intraoral molding were compared: (i) stepwise manual design of molding plates (conventional CAD/CAM-intraoral molding) and (ii) a semi-automated approach with an automated detection of alveolar ridges (called RapidNAM) assisted by a graphical user interface (GUI). Both approaches significantly narrowed the clefts and resulted in a harmonic alveolar crest alignment. The GUI was easy to use and generated intraoral molding devices within minutes. The presented design solution is an efficient technical refinement with good clinical results. The semi-automated plate generation with a feasible GUI is fast but allows individual adaptations. This promising technique might facilitate and foster the more widespread use of CAD/CAM-technology in intraoral molding therapy.
Active Transport of Peptides Across the Intact Human Tympanic Membrane
Authors: Kurabi Arwa , Schaerer Daniel , Noack Volker , Bernhardt Marlen , Pak Kwang , Alexander Thomas , Husseman Jacob , Nguyen Quyen , Harris Jeffrey P. , Ryan Allen F.
Published: August 2018

We previously identified peptides that are actively transported across the intact tympanic membrane (TM) of rats with infected middle ears. To assess the possibility that this transport would also occur across the human TM, we first developed and validated an assay to evaluate transport in vitro using fragments of the TM. Using this assay, we demonstrated the ability of phage bearing a TM-transiting peptide to cross freshly dissected TM fragments from infected rats or from uninfected rats, guinea pigs and rabbits. We then evaluated transport across fragments of the human TM that were discarded during otologic surgery. Human trans-TM transport was similar to that seen in the animal species. Finally, we found that free peptide, unconnected to phage, was transported across the TM at a rate comparable to that seen for peptide-bearing phage. These studies provide evidence supporting the concept of peptide-mediated drug delivery across the intact TM and into the middle ears of patients.
Citrobacter freundii fitness during bloodstream infection
Authors: Anderson Mark T. , Mitchell Lindsay A. , Zhao Lili , Mobley Harry L. T.
Published: August 2018

Sepsis resulting from microbial colonization of the bloodstream is a serious health concern associated with high mortality rates. The objective of this study was to define the physiologic requirements of Citrobacter freundii in the bloodstream as a model for bacteremia caused by opportunistic Gram-negative pathogens. A genetic screen in a murine host identified 177 genes that contributed significantly to fitness, the majority of which were broadly classified as having metabolic or cellular maintenance functions. Among the pathways examined, the Tat protein secretion system conferred the single largest fitness contribution during competition infections and a putative Tat-secreted protein, SufI, was also identified as a fitness factor. Additional work was focused on identifying relevant metabolic pathways for bacteria in the bloodstream environment. Mutations that eliminated the use of glucose or mannitol as carbon sources in vitro resulted in loss of fitness in the murine model and similar results were obtained upon disruption of the cysteine biosynthetic pathway. Finally, the conservation of identified fitness factors was compared within a cohort of Citrobacter bloodstream isolates and between Citrobacter and Serratia marcescens, the results of which suggest the presence of conserved strategies for bacterial survival and replication in the bloodstream environment.
Zn1−xTex Ovonic Threshold Switching Device Performance and its Correlation to Material Parameters
Authors: Koo Yunmo , Hwang Hyunsang
Published: August 2018

We have experimentally demonstrated a strong correlation between the electrical properties of Zn1−xTex Ovonic threshold switching (OTS) selector device and the material properties analysed by X-ray diffraction (XRD), spectroscopic ellipsometry, and X-ray photoelectron spectroscopy (XPS). The correlation and the key material parameters determining the device performances were investigated. By comparing the experimental data with the calculation results from various analytical models previously developed for OTS materials, the electrical properties of the device were shown to be dependent on the key material parameters; the concentration of sub-gap trap states and the bandgap energy of the OTS material. This study also experimentally demonstrated that those key parameters have determined the device performance as expected from the analytical model. The origin of the OTS phenomenon and conduction mechanism were explained both experimentally and theoretically. This leads to better understanding of the conduction mechanism of OTS devices, and an insight for process improvement to optimize device performance for selector application.
A simple all-fiber comb filter based on the combined effect of multimode interference and Mach-Zehnder interferometer
Authors: Zhou Guorui , Kumar Rahul , Wu Qiang , Ng Wai Pang , Binns Richard , Lalam Nageswara , Miao Xinxiang , Niu Longfei , Yuan Xiaodong , Semenova Yuliya , Farrell Gerald , Yuan Jinhui , Yu Chongxiu , Sang Xinzhu , Xin Xiangjun , Liu Bo , Lv Haibing , Fu Yong Qing
Published: August 2018

A polarization-dependent all-fiber comb filter based on a combination effect of multimode interference and Mach-Zehnder interferometer was proposed and demonstrated. The comb filter was composed with a short section of multimode fiber (MMF) fusion spliced with a conventional single mode fiber on the one side and a short section of a different type of optical fiber on the other side. The second type of optical fiber is spliced to the MMF with a properly designed misalignment. Different types and lengths of fibers were used to investigate the influence of fiber types and lengths on the performance of the comb filter. Experimentally, several comb filters with free spectral range (FSR) values ranging from 0.236 to 1.524 nm were achieved. The extinction ratio of the comb filter can be adjusted from 6 to 11.1 dB by varying polarization states of the input light, while maintaining the FSR unchanged. The proposed comb filter has the potential to be used in optical dense wavelength division multiplexing communication systems.
Formulation, characterization and evaluation of mRNA-loaded dissolvable polymeric microneedles (RNApatch)
Authors: Koh Kai Jun , Liu Yi , Lim Seng Han , Loh Xian Jun , Kang Lifeng , Lim Chee Yen , Phua Kyle K. L.
Published: August 2018

In this paper, we report a proof of concept study on the fabrication, characterization and therapeutic evaluation of in vitro transcribed messenger RNA (mRNA) loaded in a dissolving microneedle patch (RNApatch). We show that low molecular weight polyvinylpyrrolidone (PVP) can directly be used without further purification for RNApatch fabrication with no detectable mRNA degradation. Physical and functional integrity of mRNA stored within the RNApatch are completely preserved for at least 2 weeks under ambient conditions. While the loading of mRNA into RNApatch is limited by the solubility of mRNA in concentrated PVP solution, mechanical strength of RNApatch is not compromised by the presence of mRNA. RNApatch can mediate in vivo transgene expression of mRNA encoding luciferase for up to 72 hours and transfection efficiency and kinetics mediated by RNApatch compares favorably to subcutaneous injection. Interestingly, mRNA transfection efficiency does not correlate with contact surface area but instead increases with deeper delivery depths. In an E.G7-OVA immunotherapy model, RNApatch induces slightly higher cellular and humoral immune responses compared to subcutaneous injection. In conclusion, RNApatch is a viable delivery platform for mRNA and represents an attractive option with significant translation potential for the delivery of mRNA therapeutics.
Instability-Induced Pattern Transformation in Soft Metamaterial with Hexagonal Networks for Tunable Wave Propagation
Authors: Gao Chao , Slesarenko Viacheslav , Boyce Mary C. , Rudykh Stephan , Li Yaning
Published: August 2018

Instability-induced pattern transformations of the architectured multi-phase soft metamaterial under bi-axial compression were explored. The soft metamaterial is composed of two phases: a soft matrix and a reinforcing hexagonal network embedded in the matrix. Equi-biaxial loading is found to induce both micro- and macro- instabilities in the networked architecture. Two types of instability patterns were observed, dependent upon the architecture geometry and the material combination. The critical strain for triggering instability and the two resulting types of patterns was derived, and a theoretical criterion for the transition between the two patterns was determined. Type I patterns retain the original periodicity of the architecture but wrinkles the network walls whereas Type II patterns transform the overall periodicity of the architecture while bending the network walls. Elastic wave propagation analysis was performed for the two distinct patterns under both stressed and stress-free conditions: a change in band gaps is found for both instability-induced pattern transformations, but differs for each type due to their dramatic difference in structure transformation (i.e. Type I wall wrinkling vs. Type II periodicity switching). The distinguished mechanical behavior and the rich properties of this category of multi-phase soft metamaterial can be used to design new smart materials with switchable functionalities controllable by deformation.
The role of lipids in the inception, maintenance and complications of dengue virus infection
Authors: Melo Carlos Fernando Odir Rodrigues , Delafiori Jeany , Dabaja Mohamad Ziad , de Oliveira Diogo Noin , Guerreiro Tatiane Melina , Colombo Tatiana Elias , Nogueira Maurício Lacerda , Proenca-Modena Jose Luiz , Catharino Rodrigo Ramos
Published: August 2018

Dengue fever is a viral condition that has become a recurrent issue for public health in tropical countries, common endemic areas. Although viral structure and composition have been widely studied, the infection phenotype in terms of small molecules remains poorly established. This contribution providing a comprehensive overview of the metabolic implications of the virus-host interaction using a lipidomic-based approach through direct-infusion high-resolution mass spectrometry. Our results provide further evidence that lipids are part of both the immune response upon Dengue virus infection and viral infection maintenance mechanism in the organism. Furthermore, the species described herein provide evidence that such lipids may be part of the mechanism that leads to blood-related complications such as hemorrhagic fever, the severe form of the disease.
A universal bioluminescence resonance energy transfer sensor design enables high-sensitivity screening of GPCR activation dynamics
Authors: Schihada Hannes , Vandenabeele Sylvie , Zabel Ulrike , Frank Monika , Lohse Martin J. , Maiellaro Isabella
Published: August 2018

G-protein-coupled receptors (GPCRs) represent one of the most important classes of drug targets. The discovery of new GCPR therapeutics would greatly benefit from the development of a generalizable high-throughput assay to directly monitor their activation or de-activation. Here we screened a variety of labels inserted into the third intracellular loop and the C-terminus of the α2A-adrenergic receptor and used fluorescence (FRET) and bioluminescence resonance energy transfer (BRET) to monitor ligand-binding and activation dynamics. We then developed a universal intramolecular BRET receptor sensor design to quantify efficacy and potency of GPCR ligands in intact cells and real time. We demonstrate the transferability of the sensor design by cloning β2-adrenergic and PTH1-receptor BRET sensors and monitored their efficacy and potency. For all biosensors, the Z factors were well above 0.5 showing the suitability of such design for microtiter plate assays. This technology will aid the identification of novel types of GPCR ligands.
Na1.5La1.5TeO6: Na+ conduction in a novel Na-rich double perovskite
Authors: Amores Marco , Baker Peter J. , Cussen Edmund J. , Corr Serena A.
Published: August 2018

A novel Na-rich double perovskite, Na1.5La1.5TeO6, is reported. The transport properties, explored at the macroscopic and local level, reveal a low activation energy barrier for Na+ diffusion and great promise for use as an electrolyte for all solid-state Na-batteries.
Immunoglobulin light chain amyloid aggregation
Authors: Blancas-Mejia Luis M. , Misra Pinaki , Dick Christopher J. , Cooper Shawna A. , Redhage Keely R. , Bergman Michael R. , Jordan Torri L. , Maar Khansaa , Ramirez-Alvarado Marina
Published: August 2018

Light chain (AL) amyloidosis is a devastating, complex, and incurable protein misfolding disease.
Branch-PCR constructed TP53 gene nanovector for potential cancer therapy
Authors: Cheng Longhuai , Deng Huiting , Ma Dejun , Zhai Beibei , Zhang Qiangzhe , Li Luyuan , Xi Zhen
Published: August 2018

A novel and efficient branch PCR strategy can be used to construct a TP53 gene nanovector for effective cancer therapy.
A cytotoxic tantalum(v) half-sandwich complex: a new challenge for metal-based anticancer agents
Authors: Štarha Pavel , Trávníček Zdeněk , Dvořák Zdeněk
Published: August 2018

The new and pharmacologically promising electroneutral half-sandwich Ta(v)-dichlorido Schiff-base complex was described.
Superior high rate capability of MgMn2O4/rGO nanocomposites as cathode materials for aqueous rechargeable magnesium ion batteries
Authors: Liu Guang , Chi Qingguo , Zhang Yongquan , Chen Qingguo , Zhang Changhai , Zhu Kai , Cao Dianxue
Published: August 2018

Incorporation of reduced graphene oxide (rGO) optimizes the interfacial properties of MgMn2O4 and improves the Mg2+ diffusion in the electrode.
Induced circular dichroism of monoatomic anions: silica-assisted the transfer of chiral environment from molecular assembled nanohelices to halide ions
Authors: Okazaki Yutaka , Ryu Naoya , Buffeteau Thierry , Pathan Shaheen , Nagaoka Shoji , Pouget Emilie , Nlate Sylvain , Ihara Hirotaka , Oda Reiko
Published: August 2018

Induced CD of monoatomic anions was detected using silica-coated molecular assembled nanohelices and multi-step chirality induction was achieved through an in situ chemical reaction via chiralized monoatomic anions.
Arsagermene, a compound with an –AsGe double bond
Authors: Lee Vladimir Ya. , Kawai Manami , Gapurenko Olga A. , Minkin Vladimir I. , Gornitzka Heinz , Sekiguchi Akira
Published: August 2018

Arsagermene, a stable compound featuring an AsGe double bond, was synthesized, isolated, and structurally characterized for the first time.
Correction: PEG-nanotube liquid crystals as templates for construction of surfactant-free gold nanorods
Authors: Kameta Naohiro , Shiroishi Hidenobu
Published: August 2018

Correction for ‘PEG-nanotube liquid crystals as templates for construction of surfactant-free gold nanorods’ by Naohiro Kameta et al., Chem. Commun., 2018, 54, 4665–4668.
A 2D ferromagnetic semiconductor in monolayer Cr-trihalide and its Janus structures
Authors: Moaied Mohammed , Lee Jiyoul , Hong Jisang
Published: August 2018

Using first principles calculations, we explored the physical properties of two-dimensional (2D) Cr-trihalide X3–Cr2–X3 or CrX3 (X = Cl, Br, I) and its Janus monolayers X3–Cr2–Y3 (X and Y = Cl, Br, I) where X ≠ Y.
15-Copper(ii)-containing 36-tungsto-4-silicates(iv) [Cu15O2(OH)10X(A-α-SiW9O34)4]25−(X = Cl, Br): synthesis, structure, magnetic properties, and electrocatalytic CO2reduction
Authors: Bassil Bassem S. , Haider Ali , Ibrahim Masooma , Mougharbel Ali S. , Bhattacharya Saurav , Christian Jonathan H. , Bindra Jasleen K. , Dalal Naresh S. , Wang Meng , Zhang Guangjin , Keita Bineta , Rutkowska Iwona A. , Kulesza Pawel J. , Kortz Ulrich
Published: August 2018

Two novel Cu15-containing polyoxometalates are active and selective catalysts for electrochemical CO2reduction.
A ZnO/ZnFe2O4 uniform core–shell heterojunction with a tubular structure modified by NiOOH for efficient photoelectrochemical water splitting
Authors: Lan Yayao , Liu Zhifeng , Guo Zhengang , Li Xifei , Zhao Lei , Zhan Li , Zhang Min
Published: August 2018

It is known that heterojunction photoelectrodes can improve light absorption and accelerate the separation of photogenerated carriers in the field of photoelectrochemical (PEC) water splitting.
Correction: Development of P3-K0.69CrO2 as an ultra-high-performance cathode material for K-ion batteries
Authors: Hwang Jang-Yeon , Kim Jongsoon , Yu Tae-Yeon , Myung Seung-Taek , Sun Yang-Kook
Published: August 2018

Correction for ‘Development of P3-K0.69CrO2 as an ultra-high-performance cathode material for K-ion batteries’ by Jang-Yeon Hwang et al., Energy Environ. Sci., 2018, DOI: 10.1039/c8ee01365a.
Surface adsorption of Nordic aquatic fulvic acid on amine-functionalized and non-functionalized mesoporous silica nanoparticles
Authors: Jayalath Sanjaya , Larsen Sarah C. , Grassian Vicki H.
Published: August 2018

Mesoporous silica nanoparticles (MSNs) have the potential to be released into the environment and to then adsorb natural organic matter.
Anaerobic membrane gas extraction facilitates thermophilic hydrogen production fromClostridium thermocellum
Authors: Singer Scott , Magnusson Lauren , Hou Dianxun , Lo Jonathan , Maness Pin-Ching , Ren Zhiyong Jason
Published: August 2018

Clostridium thermocellumis among the most efficient bacteria to convert cellulosic biomass into H2during dark fermentation.
Renewable energy storage via efficient reversible hydrogenation of piperidine captured CO2
Authors: Lu Mi , Zhang Jianghao , Yao Yao , Sun Junming , Wang Yong , Lin Hongfei
Published: August 2018

A highly efficient formate-piperidine-adduct based hydrogen storage system was developed. High-purity hydrogen can be produced with superior reaction kinetics under mild conditions. By integrating this system with renewable hydrogen and fuel cells, in-demand rechargeable hydrogen batteries could be realized for storing renewable energy.
Bio-electrorecycling of carbon dioxide into bioplastics
Authors: Pepè Sciarria T. , Batlle-Vilanova P. , Colombo B. , Scaglia B. , Balaguer M. D. , Colprim J. , Puig S. , Adani F.
Published: August 2018

The rise of carbon dioxide (CO2) emissions and the accumulation of non-biodegradable plastics in the environment is leading to an environmental crisis.
Emergence of bismuth substituted cobalt ferrite nanostructures as versatile candidates for the enhanced oxidative degradation of hazardous organic dyes
Authors: Kapoor Surbhi , Goyal Ankita , Bansal Sandeep , Singhal Sonal
Published: August 2018

The dramatic enhancement in the catalytic performance with the incorporation of 1% bismuth into the cobalt ferrite lattice has been scrutinized for the oxidative degradation of hazardous dyes.
Structural and computational insights into the enhanced solubility of dipfluzine by complexation: salt and salt-cocrystal
Authors: Guo Wei , Du Shuang , Lin Yulong , Lu Bo , Yang Caiqin , Wang Jing , Zeng Yanli
Published: August 2018

The solubilization of two salts and one salt-cocrystal of dipfluzine was revealed by supramolecular structures combined with lattice energies.
Visible light induced degradation of pollutant dyes using a self-assembled graphene oxide–molybdenum oxo-bis(dithiolene) composite
Authors: Mitra Joyee , Saxena Manav , Paul Navendu , Saha Ekata , Sarkar Rudra , Sarkar Sabyasachi
Published: August 2018

An easily separable graphene oxide–molybdenum oxo-bis(dithiolene) ([Ph4P]2[MoO(S2C2(CN)2)2]) composite degraded Rhodamine B and Rose Bengal dye upon visible light exposure.
Influence of particle size and shape on their margination and wall-adhesion: implications in drug delivery vehicle design across nano-to-micro scale
Authors: Cooley Michaela , Sarode Apoorva , Hoore Masoud , Fedosov Dmitry A. , Mitragotri Samir , Sen Gupta Anirban
Published: August 2018

Intravascular drug delivery technologies majorly utilize spherical nanoparticles as carrier vehicles.
Combined reversible switching of ECD and quenching of CPL with chiral fluorescent macrocycles
Authors: Homberg Alexandre , Brun Elodie , Zinna Francesco , Pascal Simon , Górecki Marcin , Monnier Luc , Besnard Céline , Pescitelli Gennaro , Di Bari Lorenzo , Lacour Jérôme
Published: August 2018

A series of chiral fluorescent macrocycles display a remarkable combination of both +/– ECD and strong on/off CPL reversible switching upon cation binding and displacement.
The role of electrostatic repulsion in the gelation of poly(vinyl alcohol)/borax aqueous solutions
Authors: Li Jingjing , Zhang Zhijie , Cao Xiao , Liu Yonggang , Chen Quan
Published: August 2018

This study examined linear viscoelasticity of semidilute non-entangled poly(vinyl alcohol) (PVA) and borax aqueous solutions: one borax molecule dissociates into two B(OH)3molecules and two B(OH)4−ions, and the latter can crosslink the PVA chains.
Facile synthesis of N,O-codoped hard carbon on the kilogram scale for fast capacitive sodium storage
Authors: Huang Man , Xi Baojuan , Feng Zhenyu , Liu Jing , Feng Jinkui , Qian Yitai , Xiong Shenglin
Published: August 2018

The kilogram-scale preparation of N,O-codoped hierarchical porous hard carbon cuttlefish-like nanowire bundles (NOHPHC) through pyrolysis of Al-based MOFs indicates the excellent sodium-storage performance due to the unique structural advantages. The present work provides inspiration for development of advanced anode materials for practical sodium-ion battery application.
Correction: Pulsatile release from a flat self-oscillating chitosan macrogel
Authors: Anna Isakova , Katarina Novakovic
Published: August 2018

Correction for ‘Pulsatile release from a flat self-oscillating chitosan macrogel’ by Isakova Anna et al., J. Mater. Chem. B, 2018, DOI: 10.1039/c8tb00781k.
Identification of a novel c-Myc inhibitor with antitumor effects on multiple myeloma cells
Authors: Yao Ruosi , Sun Xiaoyang , Xie Yu , Sun Xiaoshen , Yao Yao , Li Hujun , Li Zhenyu , Gao Jian , Xu Kailin
Published: August 2018

Increasing evidence shows that c-Myc oncoprotein is tightly associated with multiple myeloma (MM) progression. Herein, we identified compound 7594-0035, which is a novel inhibitor that specifically targets c-Myc. It was identified from the ChemDiv compound database by molecular docking-based, high-throughput virtual screening. Compound 7594-0035 inhibited MM cell proliferation in vitro, induced cell cycle G2-phase arrest, and triggered MM cell death by disturbing the stability of c-Myc protein. Additionally, we also found that compound 7594-0035 overcame bortezomib (BTZ) drug resistance and increased the killing effect on MM cells in combination with BTZ. The severe combined immune deficiency (SCID) mouse xenograft model revealed that compound 7594-0035 partially decreased the primary tumor growth of Roswell Park Memorial Institute (RPMI)-8226 cells in vivo. The novel small molecular compound 7594-0035 described in the present study that targets c-Myc protein is likely to be a promising therapeutic agent for relapsed/refractory MM.
Structural basis of inactivation of human counterpart of mouse motor neuron degeneration 2 mutant in serine protease HtrA2
Authors: Wagh Ajay R. , Bose Kakoli
Published: August 2018

Serine protease high temperature requirement protease A2 (HtrA2) is involved in apoptosis and protein quality control. However, one of its murine inactive mutants (S276C aka mnd2) is associated with motor neuron degeneration 2. Similarly, this conserved mutation in human HtrA2 (hHtrA2) also renders the protease inactive, implicating pathogenicity. However, the structural determinants for its inactivation have not yet been elucidated. Here, using multidisciplinary approach, we studied the structural basis of inactivity associated with this mutation in hHtrA2. Characterization of secondary and tertiary structural properties, protein stability, oligomeric properties, and enzyme activity for both wild-type and mutant has been performed using biophysical and functional enzymology studies. The structural comparison at atomic resolution has been carried out using X-ray crystallography. While enzyme kinetics showed inactivity, spectroscopic probes did not identify any significant secondary structural changes in the mutant. X-ray crystallographic analysis of the mutant protein at 2 Å resolution highlighted the significance of a water molecule that plays important role in mediating intermolecular interactions for maintaining the functional ensemble of the protease. Overall, the crystallographic data along with biophysical and enzymology studies helped decipher the structural basis of inactivity of hHtrA2S276C, which might pave way toward further investigating its correlation with aberration of normal cellular functions, hence pathogenicity.
Effects of Specific Language Impairment on a Contrastive Dialect Structure: The Case of Infinitival TO Across Various Nonmainstream Dialects of English
Authors: Rivière Andrew M. , Oetting Janna B. , Roy Joseph
Published: August 2018

Purpose

Using data from children who spoke various nonmainstream dialects of English and who were classified as either children with specific language impairment (SLI) or typically developing (TD) children, we examined children's marking of infinitival TO by their dialect and clinical status.

Method

The data came from 180 kindergartners (91 speakers of African American English, 60 speakers of Southern White English, 29 speakers of +Cajun); 53 were children with SLI, and 127 were TD children. Data included 4,537 infinitival TO contexts extracted from language samples; each was coded as zero or overtly marked and by preceding verb context (i.e., verbs of motion vs. other).

Results

Across dialects, overall rates of zero marking differed by the children's clinical status (SLI > TD), and other verb contexts accounted for this result. Across the TD and SLI groups, dialect variation was evident for verbs of motion contexts, and the effect was stronger for the TD than for the SLI groups, particularly if the TD children's dialects were classified as +Cajun.

Conclusion

Children's marking of infinitival TO can be affected by both their dialect and clinical status. Results support language assessments that include context-specific rate-based measures of infinitival TO and other contrastive structures when they prove useful for understanding the linguistic profile of SLI within a dialect.
Executive Function in Deaf Children: Auditory Access and Language Access
Authors: Hall Matthew L. , Eigsti Inge-Marie , Bortfeld Heather , Lillo-Martin Diane
Published: August 2018

Purpose

Deaf children are frequently reported to be at risk for difficulties in executive function (EF); however, the literature is divided over whether these difficulties are the result of deafness itself or of delays/deficits in language that often co-occur with deafness. The purpose of this study is to discriminate these hypotheses by assessing EF in populations where the 2 accounts make contrasting predictions.

Method

We use a between-groups design involving 116 children, ages 5–12 years, across 3 groups: (a) participants with normal hearing (
n
= 45), (b) deaf native signers who had access to American Sign Language from birth (
n
= 45), and (c) oral cochlear implant users who did not have full access to language prior to cochlear implantation (
n
= 26). Measures include both parent report and performance-based assessments of EF.

Results

Parent report results suggest that early access to language has a stronger impact on EF than early access to sound. Performance-based results trended in a similar direction, but no between-group differences were significant.

Conclusions

These results indicate that healthy EF skills do not require audition and therefore that difficulties in this domain do not result primarily from a lack of auditory experience. Instead, results are consistent with the hypothesis that language proficiency, whether in sign or speech, is crucial for the development of healthy EF. Further research is needed to test whether sign language proficiency also confers benefits to deaf children from hearing families.
Room temperature continuous wave operation of InAs/AlSb‐based quantum cascade laser at λ ∼11 µm
Authors: Loghmari Z. , Bahriz M. , Thomas D. Díaz , Meguekam A. , Van H. Nguyen , Teissier R. , Baranov A.N.
Published: August 2018

The InAs/AlSb quantum cascade lasers (QCLs) operating ∼11 µm in the continuous wave (cw) regime at room temperature are reported. The lasers with cleaved Fabry–Perot resonators demonstrated pulsed threshold current densities below 1 kA/cm2 at 300 K and operated in a cw up to 320 K that is the maximum temperature of such regime of operation for InAs‐based QCLs. Distributed feedback lasers fabricated from the same wafer exhibited single frequency emission near 11 µm and operated in the cw regime up to 295 K.
Incoherent waveform design for compressed sensing radar based on pulse‐train scenario
Authors: Entezari Rahim , Rashidi Alijabbar
Published: August 2018

Waveform design plays an important role in compressed sensing radar (CSR). The performance of the target scene recovery in CSR scenarios depends on the mutual coherence of the sensing matrix, which is determined by the radar transmission waveform. In this study, the authors propose a waveform optimisation method for pulse‐train scenario through solving the matrix nearness problem between the Gram matrix and the identity matrix. This method has a simple closed‐form solution and simulation results show that the proposed method is more efficient than the current waveforms such as linear frequency modulation (LFM), Gaussian and Alltop sequences in terms of mutual coherence, recovery errors and recovery percentages.
Robust tracking of multiple objects in video by adaptive fusion of subband particle filters
Authors: Mahmoud Ahmed , Sherif Sherif S.
Published: August 2018

Tracking of moving objects in video sequences is an important research problem because of its many industrial, biomedical, and security applications. Significant progress has been made on this topic in the last few decades. However, the ability to track objects accurately in video sequences that have challenging conditions and unexpected events, e.g. background motion and shadows; objects with different sizes and contrasts; a sudden change in illumination; partial object camouflage; and low signal‐to‐noise ratio, remains an important research problem. To address such difficulties, the authors developed a robust multiscale visual tracker that represents a captured video frame as different subbands in the wavelet domain. It then applies N independent particle filters to a small subset of these subbands, where the choice of this subset of wavelet subbands changes with each captured frame. Finally, it fuses the outputs of these N independent particle filters to obtain final position tracks of multiple moving objects in the video sequence. To demonstrate the robustness of their multiscale visual tracker, they applied it to four example videos that exhibit different challenges. Compared to a standard full‐resolution particle filter‐based tracker and a single wavelet subband (LL)2‐based tracker, their multiscale tracker demonstrates significantly better tracking performance.
INTRALOG – intelligent autonomous truck applications in logistics; single and double articulated autonomous rearward docking on DCs
Authors: Kusumakar Rakshith , Buning Lejo , Rieck Frank , Schuur Peter , Tillema Frans
Published: August 2018

Vehicle automation opens opportunities toward the improvement of people, planet, profit value in applications on distribution centres (DCs). Despite vision and drive for innovation in logistics, the lack of knowledge prevents the application of autonomous applications. Intelligent Truck Applications in Logistics (INTRALOG) contributes to this deficit and generates valuable insights for a future application in public environments. Current operational automated guided truck applications are bound to fixed infrastructure and do neither operate in the public domain nor offer opportunities to do so. Nowadays, in‐vehicle intelligent systems are focused on driver support, opening opportunities such as truck platooning. INTRALOG cross‐borders on DCs in relatively low‐complex traffic environment, bridging the gap between autonomous driving in the public domain. The multi‐agent system developed within INTRALOG aligns logistical movements on DCs, controlling single or double articulated container trailers (longer and heavier vehicle) between the public parking area and cross‐docks. This study elaborates on the experiments on automated manoeuvring on a DC with single (SAVs) and double articulated vehicles (DAVs). The experiments comply with business requirements, e.g. manoeuvrability, time to dock and positioning accuracy. The research focuses on the effects of these aspects and control strategies of SAVs and DAVs.
Lifetime maximisation of disjoint wireless sensor networks using multiobjective genetic algorithm
Authors: El‐Sherif Mohamed , Fahmy Yasmine , Kamal Hanan
Published: August 2018

One of the lifetime maximisation methods for wireless sensor network (WSN) depends on organising the dense sensors into groups which can work in a cooperative sequential manner. Each group contains a subset of sensors that cover all the monitored area and is called a complete cover or simply a cover. Increasing the number of organised covers and maximising the covers lifetime enable longer network lifetime. Here, the authors investigate the WSN lifetime problem as a two‐objective optimisation problem. The first objective is to find the maximum number of covers. The second objective considers the problem of wasted energy. Minimising the wasted energy in the critical sensors is achieved by defining a difference factor (DF). The DF is an indication of the difference between the critical sensor lifetime and the cover lifetime. This second objective is compared with other choices in the literature such as minimising the overlapping and minimising the variance. This optimisation problem is addressed using non‐dominated sorting genetic algorithm‐II (NSGA‐II). Simulation results are conducted for the network lifetime when using one‐objective and different two‐objective optimisation problem. The choice of DF as the second objective is proved to overcome drawbacks of other second objectives choices.
Solution to overcome the sparsity issue of annotated data in medical domain
Authors: Pujitha Appan K. , Sivaswamy Jayanthi
Published: August 2018

Annotations are critical for machine learning and developing computer aided diagnosis (CAD) algorithms. Good performance of CAD is critical to their adoption, which generally rely on training with a wide variety of annotated data. However, a vast amount of medical data is either unlabeled or annotated only at the image‐level. This poses a problem for exploring data driven approaches like deep learning for CAD. In this paper, we propose a novel crowdsourcing and synthetic image generation for training deep neural net‐based lesion detection. The noisy nature of crowdsourced annotations is overcome by assigning a reliability factor for crowd subjects based on their performance and requiring region of interest markings from the crowd. A generative adversarial network‐based solution is proposed to generate synthetic images with lesions to control the overall severity level of the disease. We demonstrate the reliability of the crowdsourced annotations and synthetic images by presenting a solution for training the deep neural network (DNN) with data drawn from a heterogeneous mixture of annotations. Experimental results obtained for hard exudate detection from retinal images show that training with refined crowdsourced data/synthetic images is effective as detection performance in terms of sensitivity improves by 25%/27% over training with just expert‐markings.
The impact crater at the origin of the Julia family detected with VLT/SPHERE?
Authors: Vernazza P. , Brož M. , Drouard A. , Hanuš J. , Viikinkoski M. , Marsset M. , Jorda L. , Fetick R. , Carry B. , Marchis F. , Birlan M. , Fusco T. , Santana-Ros T. , Podlewska-Gaca E. , Jehin E. , Ferrais M. , Bartczak P. , Dudziński G. , Berthier J. , Castillo-Rogez J. , Cipriani F. , Colas F. , Dumas C. , Ďurech J. , Kaasalainen M. , Kryszczynska A. , Lamy P. , Le Coroller H. , Marciniak A. , Michalowski T. , Michel P. , Pajuelo M. , Tanga P. , Vachier F. , Vigan A. , Warner B. , Witasse O. , Yang B. , Asphaug E. , Richardson D. C. , Ševeček P. , Gillon M. , Benkhaldoun Z.
Published: August 2018

Context.The vast majority of the geophysical and geological constraints (e.g., internal structure, cratering history) for main-belt asteroids have so far been obtained via dedicated interplanetary missions (e.g., ESA Rosetta, NASA Dawn). The high angular resolution of SPHERE/ZIMPOL, the new-generation visible adaptive-optics camera at ESO VLT, implies that these science objectives can now be investigated from the ground for a large fraction ofD≥ 100 km main-belt asteroids. The sharp images acquired by this instrument can be used to accurately constrain the shape and thus volume of these bodies (hence density when combined with mass estimates) and to characterize the distribution and topography ofD≥ 30 km craters across their surfaces.

Aims.Here, via several complementary approaches, we evaluated the recently proposed hypothesis that the S-type asteroid (89) Julia is the parent body of a small compact asteroid family that formed via a cratering collisional event.

Methods.We observed (89) Julia with VLT/SPHERE/ZIMPOL throughout its rotation, derived its 3D shape, and performed a reconnaissance and characterization of the largest craters. We also performed numerical simulations to first confirm the existence of the Julia family and to determine its age and the size of the impact crater at its origin. Finally, we utilized the images/3D shape in an attempt to identify the origin location of the small collisional family.

Results.On the one hand, our VLT/SPHERE observations reveal the presence of a large crater (D~ 75 km) in Julia’s southern hemisphere. On the other hand, our numerical simulations suggest that (89) Julia was impacted 30–120 Myrs ago by aD~ 8 km asteroid, thereby creating aD≥ 60 km impact crater at the surface of Julia. Given the small size of the impactor, the obliquity of Julia and the particular orientation of the family in the (a,i) space, the imaged impact crater is likely to be the origin of the family.

Conclusions.New doors into ground-based asteroid exploration, namely, geophysics and geology, are being opened thanks to the unique capabilities of VLT/SPHERE. Also, the present work may represent the beginning of a new era of asteroid-family studies. In the fields of geophysics, geology, and asteroid family studies, the future will only get brighter with the forthcoming arrival of 30–40 m class telescopes like ELT, TMT, and GMT.
Potency of Different Seaweeds as Diets for Developing Abalone (H. squamata) Culture in Nusa Penida Island, Bali
Authors: Heru Prihadi Tri , Rasidi  , Ardi Idil , Widiyati Ani , Budi Wiyanto Dwi
Published: August 2018

Nusa Penida island is one of center for seaweed culture in Bali province. Seaweed that cultured is Euchema spinosum and Euchema cottoni spread around coastal. There also found wild seaweed, such as Ulva sp and Gracillaria sp. Abalone (H. squamata) is one of kind Mollusca which high economic value, but abalone cultured is not yet develop in Nusa Penida island, although this island have high potency for developing abalone culture. Abalone culture needs seaweeds as a diet. The abundance of seaweeds as abalon diet is important for developing abalon culture in Nusa Penida Island in the future. The aim of this research was to asses the potency of seaweeds as diet for developing abalone culture in Nusa Penida island. Research was done in Batununggul village, Nusa Penida Island. Experimental design was used Completely Randomized Design (CRD) with 3 treatments and 3 replications. The treatments were used different seaweeds as diet for abalone culture: (DG=Diet Gracillaria sp, DS=Diet Spinosum sp. and DU=Diet Ulva sp.). Abalon were cultured for 4 months by feeding the diet at satiation. Data analysis was used analysis varian (Anova) with SPSS. 16. The result showed abalon fed with Gracillaria sp (DG) at 4.73 g was the highest growth by 4.73 g, followed DU by 3.93 g and DS by 3.43 g. Meanwhile the abalon shell length fed with Gracillaria sp (DG) was the highest growth by 6.55 mm, followed DU by 5.97 mm and DS by 5.60 mm. Based on variant analysis showed growth performance (length shell and weight) abalon, all treatments were not significantly different (P>0.05). The conclusion this research, the three species of seaweed can be used as diet for abalone culture. These seaweeds have same potency as diet for developing abalone culture in Nusa Penida Island
Biodiversity of algae potentially HABS (Harmfull Algae Blooms) in reservoir Mrica, Banjarnegara
Authors: Andriyani Nuraina , Mahdiana Arif , Dewi Rose , Subagyo Yusuf , sahri siregar Asrul , Junaidi Teuku , harisam Taufan
Published: August 2018

It has been reported that the waters of the reservoir Mrica-Banjarnegara were mesotropik-hypereutrophic conditions, potential algal bloom is of Division: Cyanophyta is Microcystis; Chlorophyta is pediastrum; Chrysophyceae is Pyrophyta nitzchia and is Ceratium. Research the types of algae that Potentially HABS (harmfull Algae Blooms) has been Carried out as a continuation of the kinds of research that have the potential of algae blooming. Survey methods was used. Sampling was done by purposive sampling, through 5 (five) sampling sites. Data were Analyzed descriptively. The results Showed that the algae are Potentially HABS of the division Cyanophyta are Microcystis, Anabaena, Oscillatoria and phormidium.
Spatio-Temporal Distribution of Chlorophyll-a Using Multitemporal Landsat Image and Ground Check in Segara Anakan Lagoon
Authors: Dewi Rose , Zainuri Muhammad , Anggoro Sutrisno , Winanto Tjahjo , Endrawati Hadi
Published: August 2018

Segara Anakan lagoon (SAL) is a dynamic estuary, downstream of several rivers in Citanduy watershed, humid tropical climate and influenced monsoon, conditions that cause waters to fluctuate. There are influence of natural and anthropogenic factors that impact on the increase of aquatic organic matter, as phytoplankton indicator biota able to show its tolerance characterized by fluctuation of chlorophyll content a. The purpose of this research is to know the spatio-temporal distribution of chlorophyll- a SAL region. The chlorophyll- a measurement method uses multitemporal landsat images and field measurements. The temporal approach (time series) during 2016 refers to the monsoon wind pattern and spatially on seven different stations of ecological characteristics. Data processing using ER Mapper 7.0 software and the preparation of thematic data with Arc GIS software. Testing data accuracy using regression analysis. The results of chlorophyll-a recording of landsat images ranged from 3,213 - 3,703 (mg / m3) and field measurements from 0.01 to 5.06 (mg / m3). Temporally transitional seasons and on spatial approaches, stations with anthropogenic characteristics have the highest chlorophyll content. The condition is supported by the accumulation of aquatic organic materials, high rainfall and upwelling phenomenon. Test of accuracy pertained high, shown with value of r = 0,94 at equation y = -30.07x2+ 217.0x - 387.0, R2= 0.894 with regression characteristic is polynomial. The high accuracy value in the equation, shows that the SAL area algorithm can be applied to obtain chlorophyll content data in the field in the previous year with the support of satellite image data in that year.
Classification of shallow water seabed profile based on Landsat 8 imagery and in-situ data. Case study in Gili Matra Island Lombok, Indonesia
Authors: Ayustina Ratih , Aulia Zahra , Mustakin Haji , Alam Fiyesti , Amron Amron , Yuwono Doddy , Ahmad Triguardi , Prayogo Aldo , Sari Fitra
Published: August 2018

Shallow water seabed profile has considerable potential resources so the availability of information which very important for coastal resources. The use of remote sensing techniques is considered to provide coastal information effective and efficient. This research aimed to determine the shallow water seabed profile based on Landsat 8 Imagery and its accuracy related to the in situ data. Methods of this research are satellite mage pre-processing, image classification, field survey, image classification, and accuracy assesment . Therefore, 6 classification of shallow water seabed profile, there are rubble (R), seagrass mixed sand (MIX -SG/SD), coral reefs mixed rubble (MIX-C/RB), rubble mixed dead coral (MIX-RB/DC), sand mixed rubble (MIX-SD/RB), and sand mixed seagrass (MIX-SD/SG), respectevely. The result of this classification has an accuracy value 80%.
Associated Of Coral Reef With Reef Fish In Northern And Southern Gili Air Island And Gili Trawangan Island Lombok
Authors: Wahyu A P Trisna , Mubarak Helmi , Lazuardy Rolian Damar , Geraldi Pardede Hanson , Prabowo  , Rizka Safitri Dhananta , Zunika Putri Kharisma , Iqbal Kenedi Muhammad , Gita Tiara Shanti Ainia , Nur Afrizal Satria , Larasayu Santoso Niken , Maharani Karina , Widyaningrum Ria , Helmi Muflih Azzam , Nur Faizan Rifki , Safitri Adini , Winanto Tjahjo
Published: August 2018

Damage to coral reef ecosystems is a major problem on the islands of Gili Air and Gili Trawangan. This will have an impact on the presence of reef fish in the area. This study aims to look how much relation caused by associated between live coral cover and reef fish in Gili Air and Gili Trawangan island.. This research method using Line Intersept Transect (LIT), Underwater Visual Census and simple linear regression analysis to know the relation. The percentage of coral cover on Gili Air Island and Gili Trawangan Island on reef flats (1-5 m) is 11.75% and 11.67% respectively, on the reef slopes (6-10 m) the percentage is 50.4% and 48.9%. In addition we observed the existence of 11 families reef fish. The abundance of reef fish on Gili Air and Gili Trawangan islands on reefs flat with an average of 0,406 ind / m2 and 0,137 ind / m2, on the reef slope on average - respectively 0,434 ind / m2 and 0,274 ind / m2. The determinant value in Southern part of both island indicates a value close to +1 and in Northern part of both island indicates a value close to -1.