bluuebunny/crossref_metadata_2025 huggingface dataset:
Study Protocol: Assessment of Racial/Ethnic Disparities in the Timeliness and Comprehensiveness of Surgery for Colorectal Cancer v1
Authors: not provided rhow , Gunaseelan Vidhya , not provided mbicket
Published: November 2021

This retrospective cohort study will investigate the timeliness of surgery based on the racial/ethnic group of patients who under colorectal surgery for cancer. Patients are included if they underwent surgical procedures for colon cancer between January 1, 2015 and April 30, 2020. The primary exposure of interest is the racial/ethnic group of the patient. The primary outcome is the the timeliness of surgery, defined as having urgent/emergent surgery (less timely) vs. elective surgery (more timely). Secondary outcomes relate to comprehensiveness of surgery, and include performance of preoperative staging tests, preoperative lab testing, and preoperative teaching of patients, as well as length of stay and additional clinical outcomes. Multivariable logistic regression models will be used to adjust for other demographic and clinical differences between study groups.
Impact of Coastal Flood on Building, Infrastructure, and Community Adaptation in Bukit Bestari Tanjungpinang
Authors: Hanif Muhammad , Putra Beben Graha , Hidayat Rizki Atthori , Ramadhan Ravidho , Ahyuni Ahyuni , Afriyadi Afriyadi , Wan Moh Jaafar Wan Shafrina , Hermon Dedi , Mokhtar Ernieza Suhana
Published: November 2021

Coastal flood in Indonesia, namely as banjir rob, is a phenomenon that increases seawater to inundate around the tidal area. In Tanjungpinang, cases of coastal floods become a serious problem for people living in this area. This research aims to model the coastal flood inundation by modeling water inundation with a maximum level increase scenario. Its model was used to estimate coastal floods' impact on houses, buildings, and infrastructures with scenario 2 meters of sea-level rise.  On the other hand, the budget loss for restoration was estimated to study the effort of community adaptations with the ECLAC RAB method and observation to understand community adaptation. It was found that the spatial model succeeded in zoning inundation areas, which had a significant impact on houses, buildings, worship places, schools, and industrial at many 4112 units. From this case, the budget loss for the restoration of the physical environment was estimated at around 61994014.75 USD. In addition, the survey revealed the existing condition before and after the coastal flood. Several community efforts for adaptation were developing houses on stilt and hoarding the lowest land on-site location for build houses.
The Role of Geographic Information Science in Achieving Sustainable Development Goals (SDGs) During The Covid-19 Pandemic
Authors: Astari Annisa Joviani , Mohamed Assem Abdelmonem Ahmed , Ridwana Riki
Published: November 2021

Sustainable development and the goals that have been set by the UN are the results of mutual agreement on various pressing issues that must be addressed by our society. Along with the pandemic conditions that hit various parts of the world, the challenges for the realization of sustainable development are getting higher. Geospatial technology offers reliable tools to support the various processes and stages of planning, analysis, problem-solving, decision making, and process management necessary to pursue this common goal. GIScience has a very important role in investigating opportunities to help solve sustainable development problems. This study presents the state of the art of how GIScience plays a role to achieve sustainable development goals particularly during pandemic covid situations which resulting in a backward for some actors in several countries to achieve these goals. This study uses the content analysis method to analyze various issues related to sustainable development, SDGs, pandemic covid-19, and GIScience. Not only providing state of the art of research, but this paper also presents how actually GIScience can help to accelerate the problems thus the ultimate goal of sustainability can be achieved.
Study of Flood-Prone Areas in Bekasi Regency
Authors: Agustina Ina Helena
Published: November 2021

Bekasi Regency is a potential area economically because there is the largest industrial area in Southeast Asia. However, Bekasi experiences the threat of flooding every year. The growth of the Bekasi Regency area has been affected by the growth of the Jakarta area, even becoming part of the JABODETABEK Metropolitan area (Jakarta-Bogor-Depok-Tangerang-Bekasi. This shows a potential location for economic growth in Bekasi Regency. Bekasi Regency is a West Java Province Region and is hydrologically included in the Regional Unit River (SWS) from the Citarum River Basin. The purpose of this study is to describe flood-prone areas in Bekasi Regency. The research method uses data collection methods by means of surveys and field observations. The data obtained are primary and secondary data, analyzed using ARCH GIS assistance to map flood-prone areas and their inundation and drainage channel conditions. The study findings will provide lessons on flood cases in Bekasi Regency. Flood cases that can provide knowledge related to cases of coastal areas and cases of areas that have high economic potential.
Upaya Meningkatkan Kompetensi Akademik Guru Kelas Melalui Pendekatan Komunikasi dan Supervisi Klinis Pengawas (Bina Gugus VII Kecamatan Cipatat Kabupaten Bandung Barat Tahun Ajaran 2017-2018)
Authors: Saepudin Usep
Published: November 2021

ABSTRAK Penelitian ini bertujuan untuk meningkatkan kompetensi Tenaga Pendidik. Penelitian dilakukan di Gugus 7 Gunungmasigit Cipatat Bandung Barat pada tanggal 02 Oktober 2017 sampai dengan tanggal 31 Desember 2017. Menggunakan Instrumen proses pembelajaran dalam supervisi akademik. Diharapkan dengan menggunakan model pendekatan tersebut dan pengarahan dari peneliti hasil supervisi akademis akan meningkat dan mampu mengaplikasikan dan memperkaya serta meningkatkan kompetensi akademik dengan baik dan benar. Dalam pelaksanaan upaya perbaikan tersebut, proses supervisi, direncanakan, diamati, dan dievaluasi hasilnya dalam dua siklus penelitian tindakan kepengawasan masing-masing 3 kali pertemuan. Dari hasil pelaksanaan Penelitian Tindakan Kepengawasan yang dilakukan dalam dua siklus dapat disimpulkan bahwa Implementasi Indikator Supervisi Akademis dapat meningkatkan kompetensi akademis guru, yang dapat diterapkan dalam peningkatan karieer dan kompetensi dasar. Hal ini dapat dilihat dari hasil evaluasi siklus I-II-III, adalah 54.00. menjadi 76.00 kemudian meningkat menjadi 84.00.dalam prosentase ketuntasan dari ketuntasan standar minimal akademis meningkat dari 54 % meningkat menjadi 76 % pada siklus I, juga pada siklus II meningkat menjadi 84 %. Para pendidik merasa puas dan termotivasi untuk mengaplikasikannya sesuai dengan waktu yang disediakan serta harmonisasi baik. Kata Kunci : Kompetensi Akademik , Proses Pembelajaran, Supervisi Akademik,. ABSTRACT This study aims to improve the competence of Educators. The research was conducted in Cluster 7 Gunungmasigit Cipatat, West Bandung on October 2, 2017 until December 31, 2017. Using the learning process in academic supervision. It is expected that using the expected model and direction from the researchers of academic supervision will increase and be able to apply and threaten to improve academic competence properly and correctly. In carrying out these improvements, the results of supervision, approval, discussion and evaluation of results in two research cycles were 3 meetings each. From the results of the implementation of the Surveillance Action Research conducted in two cycles it can be concluded that the Implementation of Academic Supervision Indicators can improve teacher academic competencies, which can be applied in improving career and basic competencies. This can be seen from the results of the evaluation cycle I-II-III, is 54.00. to 76.00 then increased to 84.00. in the percentage of completeness from completeness of academic minimum standards increased from 54% increased to 76% in the first cycle, also in the second cycle increased to 84%. The educators are satisfied and motivated to apply it according to the time provided and good harmonization. Keywords: Academic Competence;Learning Process; Academic Supervision.
THE ACTION OF FOOTBALL SUPPORTERS IN SUSTAINING SPORTS STADIUM
Authors: Anshari Faridhian
Published: November 2021

ABSTRACT The sports stadium is an important element in organizing a football match. From a number of negative cases related to the behavior of football supporters in Indonesia, the story of the destruction of stadium facilities by the supporter is quite often become the headline in various media. One of the major  events that occurred was the destruction of the Gelora Bung Karno National Stadium (GBK) facilities in the 2018 Presidential Cup final by some individuals who were thought to be supporters of the Persija Jakarta club. The biggest problem is, the stadium facilities are still in trial after renovation and  will be prepared for the 2018 ASIAN Games. Encouraged by the guilty pleasure, Jakmania as Persija  Jakarta's Supporters took an independent initiative by raising the #JagaGBK movement without any interference with the club's managerial. The purpose of this campaign is to maintain the surrounding  environment and sports facilities inside the GBK stadium. This grassroots movement involves all  Jakmania who are estimated around 45,000 people from 66 Regional Coordinators. The purpose of  this study is to understand the use of campaign techniques carried out by Jakmania in performing the  #JagaGBK campaign. This study used a qualitative approach with data collection techniques through  in-depth interviews with three resource persons: the main chairperson of Jakmania, the Jakmania  board of trustees, and the Head of branch Jakmania East Jakarta. This research resulted in findings  related to strategies in assembling member participation, similarity goal associations, efforts to unite  (integrative), giving rewards, delivering messages, gaining empathy, and giving coercion to members  who are not involved in running #JagaGBK campaigns. This research is expected to find a  formulation that can be an inspiration for other campaigns which held by the football supporters, specially regarding environmental preservation and the sports facilities.Keywords: Supporters, Football, Campaign #JagaGBK, Jakmania, and Persija Jakarta.
PEMBUATAN ABSENSI BERBASIS ANDROID MENGGUNAKAN METODE WATERFALL UNTUK PROGRAM STUDI PENDIDIKAN TEKNOLOGI INFORMASI IPI GARUT
Authors: Gunawan Rega Hadi
Published: November 2021

Abstrak Penelitian ini bertujuan untuk membangun sistem absensi dengan QR code,dan mengintegrasikan dengan Smartphone Aplikasi tersebut dapat di buat dengan menggunakan teknologi QR Code berbasis Android. Aplikasi yang dibuat diberi nama Absensi PTI. Proses pembuatan aplikasi Absensi PTI menggunakan metode Waterfall atau sering disebut juga model sekuensial linier atau alur hidup klasik. Model air terjun ini menyediakan pendekatan alur hidup perangkat lunak secara sekuensial atau terurut dimulai dari analisis, desain, pengkodean, dan pengujian. Untuk menguji kelayakan aplikasi akan digunakan standar ISO 25010 adalah 4 karakter Functional suitability, Performance efficiency, Portability, dan Usability. Pengujian dilakukan di Institut Pendidikan Indonesia Garut di jurusan Pendidikan Teknologi dan Informasi dengan jumlah mahasiswa 20 orang serta pengujian oleh dosen dan software untuk testing. Hasil dari pengujian aplikasi pada karakteristik Functional Suitability, Performance Efficiency, dan Portability dengan persentasi 100% sehingga dikatakan aplikasi sudah baik. Sedangkan untuk Usability dapat dikatakan bahwa aplikasi sudah layak untuk digunakan dengan persentase lebih dari 70 %. Kata kunci : Absensi; Android; QR code Abstract This study goals for build an attendance QR code system and integrate Smartphones. The application can be made using Android through QR Code technology. The application was created with named PTI Higher educations. The process of making the PTI Higher educations application using the “Waterfall” method or often also called a linear sequential model or classic life flow. This waterfall model provides a sequential software life cycle as a approach starting from analysis, design, coding, and testing. To test the appropriateness of the application will be used for 4 characters Functional suitability on the ISO 25010 standard, through tree indicators : Performance efficiency, Portability, and Usability. The test was conducted at the Garut Indonesia Institute of Education in the Department of Information and Technology Education with a total of 20 students as experiment sample testing. The results of application testing on the characteristics of Functional Suitability, Performance Efficiency, and Portability with a percentage of 100% so that it says the application is good. As for Usability, it can be said that the application is eligible to be used with a percentage of more than 70%. Keywords : Attendance; Android; QR code
Pengaruh Faktor Komunikasi, Sumber Daya, Disposisi dan Struktur Birokrasi dalam Implementasi Kebijakan Pelayanan Kesehatan Tradisional Integrasi Terhadap Penyelenggaraan Pelayanan Kesehatan Tradisional di Puskesmas
Authors: Riswandi Agus
Published: November 2021

AbstractRencana Strategis Kementerian Kesehatan Republik Indonesia Tahun 2015 - 2019 telah menetapkan indikator pencapaian target penyelenggaraan pelayanan kesehatan tradisional, yaitu jumlah puskesmas yang menyelenggarakan pelayanan kesehatan tradisional dan rumah sakit pemerintah yang menyelenggarakan pelayanan kesehatan tradisional. Dengan demikian kebutuhan layanan kesehatan secara terintegrasi sangat dibutuhkan di berbagai wilayah secara terintegrasi di masing-masing puskesmas, termasuk di Cimahi. Dalam penelitian ini dirumuskan untuk menjawab rumusan masalah yang mencakup: (1) Seberapa besar pengaruh faktor komunikasi dalam Implementasi Kebijakan Pelayanan Kesehatan Tradisional Integrasi terhadap Penyelenggaraan Pelayanan Kesehatan Tradisional di Puskesmas di Kota Cimahi?; (2) Seberapa besar pengaruh faktor sumberdaya dalam Implementasi Kebijakan Pelayanan Kesehatan Tradisional Integrasi terhadap Penyelenggaraan Pelayanan Kesehatan Tradisional di Puskesmas di Kota Cimahi?; (3) Seberapa besar pengaruh faktor disposisi dalam Implementasi Kebijakan Pelayanan Kesehatan Tradisional Integrasi terhadap Penyelenggaraan Pelayanan Kesehatan Tradisional di Puskesmas di Kota Cimahi?; (4) Seberapa besar pengaruh faktor struktur birokrasi dalam Implementasi Kebijakan Pelayanan Kesehatan Tradisional Integrasi terhadap Penyelenggaraan Pelayanan Kesehatan Tradisional di Puskesmas di Kota Cimahi?. Penelitian dilakukan di wilayah Kota Cimahi dengan metodologi yang digunakan dalam riset ini menggunakan pendekatan kuantitatif dengan analisis data Path Diagram untuk menguji hipotesis.  Riset ini menghasilkan temuan bahwa Faktor komunikasi telah memberikan pengaruh yang tinggi dalam Implementasi Kebijakan Pelayanan Kesehatan Tradisional Integrasi terhadap Penyelenggaraan Pelayanan Kesehatan Tradisional di Puskesmas di Kota Cimahi. Adapun faktor sumberdaya, faktor disposisi, faktor struktur birokrasi memberikan pengaruh yang sedang terhadap Implementasi Kebijakan Pelayanan Kesehatan Tradisional Integrasi terhadap Penyelenggaraan Pelayanan Kesehatan Tradisional di Puskesmas di Kota Cimahi.Kata Kunci: komunikasi; sumber daya; disposisi; struktur birokrasi; kesehatan tradisional
Implementasi Model Pembelajaran Mobile Learning Berbasis Android dalam Meningkatkan Prestasi Belajar Siswa Pada Pembelajaran Bahasa Inggris: Degrees of Comparison
Authors: Setiawati Linda , Purosad Apip , Darmawan Deni
Published: November 2021

AbstrakPenelitian ini telah dilaksanakan selama dua bulan, yakni bulan April dan Mei 2019. Selama dua bulan itu yang dilakukan oleh peneliti adalah menyerahkan surat izin penelitian ke sekolah yang dituju, menentukan observer penelitian, menentukan sampel dan populasi, menyiapkan silabus, RPP, media model pembelajaran mobile learning yang berbasis android, instrumen soal, dan instrumen lembar jawaban. Kemudian dilakukan pretest untuk mengukur kemampuan siswa sebelum mengikuti proses pembelaaran baik aspek pengetahuan maupun aspek keterampilan, setelah itu dilaksanakan proses pembelajaran di mana kelas eksperimen diterapkan model pembelajaran mobile learning yang berbasis android sedang di kelas kontrol diterapkan model pembelajaran konvensional, dan pada pertemuan berikutnya dilaksanakan posttest di kelas eksperimen dan kelas kontrol dengan dengan menggunakan instrument soal aspek pengetahuan dan keterampilan yang sama. Dan dari hasil pretest dan posttest didapatkan hasil prestasi yang sangat berbeda antara kelas eksperimen dan kelas kontrol, di mana kelas eksperimen yang menggunakan model pembelajaran mobile learning yang berbasis android mendapatkan nilai yang lebih tinggi dibandingkan dengan kelas kontrol yang menggunakan model konvensional. Menelaah dari hasil tersebut peneliti dapat menyimpulkan bahwa model pembelajaran mobile learning yang berbasis android dapat meningkatkan prestasi belajar siswa pada pelajaran Bahasa Inggris dan model pebelajaran mobile learning direkomendasikan oleh peneliti sebagai model pembelajaran yang cocok digunakan dalam proses pembelajaran baik Bahasa Inggris maupun pelajaran lainnya.
Analysis of Results of Test Resistance Isolation Power Transformator Based on Polarization Index Test and Delta Tanngen
Authors: Mulyana Elih , Hasbullah Hasbullah , Sayefullah Dzikri
Published: November 2021

The transformer is the leading equipment in the electric power system that is directly related to the electrical transmission and distribution system. An essential part of a power transformer is its insulation system. Along with age and its operation, the condition of insulation can be damaged, which can lead to failure of the surgery. The purpose of this study was to determine the quality conditions of the power transformer insulation. The method in this research is observation and study of literature, while the research location is PT PLN (Persero) TJBT APP Cirebon. Data were taken in the form of polarization index and delta tangent test results. After the data is collected, the polarization index and delta tangent are calculated and analyzed. Analysis of the polarization index testing using the primary-ground, secondary-ground, tertiary-ground, primary-secondary, secondary-tertiary, and primary-tertiary methods. Whereas tangent delta testing is the relationship between CH, CHL, CL, CT, CHT, and CLT.The results of tests with delta polarization and tangent indexes that the transformer isolation resistance is still good and the transformer is feasible to operate.
Pengaruh Terpaan Iklan Promo Gratis Ongkos Kirim Shopee Terhadap Perilaku Konsumtif Remaja
Authors: Syahida Lutfiana
Published: November 2021

Penelitian ini bertujuan untuk menganalisis apakah terdapat pengaruh signifikan antara terpaan iklan promo gratis ongkos kirim Shopee, yang dilihat dari ketiga sub variabel frekuensi, durasi, dan atensi terhadap perilaku konsumtif remaja. Jenis penelitian ini adalah penelitian deskriptif korelasional dengan menggunakan pendekatan kuantitatif. Alat pengumpulan data yang digunakan yaitu menggunakan kuesioner yang dibagikan pada 100 responden followers Twitter @ShopeeID. Hasil dari penelitian ini menunjukkan bahwa terpaan iklan promo gratis ongkos kirim Shopee berpengaruh pada perilaku konsumtif remaja. Namun hanya dua subvariabel yang berpengaruh secara signifikan terhadap perilaku konsumtif, yaitu frekuensi dan atensi. Dari ketiga sub variabel (X) yang memiliki pengaruh paling besar yaitu dimensi atensi, mengenai seberapa jauh khalayak memahami atau fokus terhadap isi pesan iklan. Sedangkan sub variabel yang memiliki pengaruh paling rendah yaitu durasi. Maka dari itu, dapat disimpulkan bahwa terpaan iklan promo gratis ongkos kirim Shopee berpengaruh secara positif pada perilaku konsumtif remaja, meskipun tidak terlalu berpengaruh besar.
STROKE REHABILITATION EXERCISE KINECT GAME AS A MODALITY FOR HOME-BASED THERAPY
Authors: Shapii Azrulhizam
Published: November 2021

Traditional rehabilitation is a tedious process which is reducing the patients' motivation to perform rehabilitation exercises. Therefore, patients need a program that can entice them to do rehabilitation exercises at home. This research aims to identify the game's needs based on the traditional rehabilitation, design a prototype of a recovery game based on traditional rehabilitation, and test the effectiveness of the rehabilitation game. There are two different game types in this rehabilitation game, with three different movement types used to interact. The prototype developed based on four elements, which are the elements of rehabilitation game, type of movement rehabilitation exercises, technology constraints faced by post-stroke patients, and the basic principle of interface design. Because of patients face physical constraints, Kinect was used in this game to interact with. Using Kinect, the patient is not bound to any device to interact with the game. The game also introduces a social background that encourages patients to have a friend to play either through competition or cooperation.By evaluating by observation and interviews, the game was accepted by post-stroke patients and their family members. They also provide a suggestion for improvement in the future. The contribution of this research is to measure whether the Kinect game console and this game can help patients do additional recovery exercises at home without the supervision of the therapist
Survival of patients with metastatic bladder cancer in the Russian Federation: results of a multicenter registry study URRU
Authors: Tsimafeyeu I. V. , Alekseeva G. N. , Petkau V. V. , Zukov R. A. , Mazhbich M. S. , Semenov A. V. , Statsenko G. B. , Novikova O. Yu. , Zaytsev I. V. , Popova I. L. , Gurina L. I. , Mukhina M. A. , Vladimirova L. Yu.
Published: November 2021

Background. Data on the overall survival (OS) of patients with metastatic bladder cancer (BCa) is rarely published.

The objective of the URRU register study is to assess OS and collect information on the administration of different treatments in patients with metastatic BCa in routine clinical practice in Russia.

Materials and methods. Patients were retrospectively identified in 9 oncology centers in different regions of Russia and included in the study if they were diagnosed with metastatic BCa between January 2017 and January 2018. We collected anonymized data online, including demographic characteristics of patients, details of their therapy, and outcomes.

Results. This study included 246 patients. Their mean age upon the diagnosis of metastatic BCa was 72 years with 60.6 % of patients over 70 years of age. The proportion of males was 74.8 %. The histological subtype of BCa (urothelial carcinoma, etc.) was identified in 70.3 % of cases. Ninety-two patients (37.4 %) received pharmacotherapy. The most common treatment option was chemotherapy (76 %); the most common drug combination was gemcitabine and cisplatin (41.3 %). Immunotherapy was used in 19.6 % of patients; 13.6 % of participants received more than two lines of therapy. Three-year OS rate was 10.6 %; median OS was 7 months (95 % confidence interval (CI) 5.4-8.6). Patients receiving systemic therapy demonstrated significantly longer survival than those receiving no therapy (21 months; 95 % CI 17.38-24.62 vs 3 months; 95 % CI 1.79-4.22; p <0.0001). Patients receiving immunotherapy had better survival than individuals receiving chemotherapy (median OS 34.5 months vs 18 months; p = 0.003).

Conclusion. The survival rates in the URRU study were relatively low, which can be attributed to the fact that only one-third of patients received pharmacotherapy and very few patients received immunotherapy. Second and subsequent lines of therapy were rarely used in patients with progressive disease. The implementation of novel treatments, including immune checkpoint inhibitors, will increase the survival of BCa patients.
Surgical treatment of giant renal tumor: a case report
Authors: Latypov V. R. , Popov O. S. , Novikov S. I. , Latypova V. N. , Ahmedov D. B.
Published: November 2021

Renal tumors account for 2 to 3 % of all malignant tumors in adults. Of all patients with renal cell carcinoma, 30 to 40 % have advanced forms of the disease. In the literature, the term "giant renal tumor" is used for tumors larger than 20 cm. In this article, we report a case of surgical treatment for a giant malignant kidney tumor.

Patient N., female, 54 years old, referred to an outpatient clinic with complaints of a change in the shape of the abdomen on the left with a palpable large tumor, abdominal pain, shortness of breath, weakness, constipation, episodes of blood in the urine and increased blood pressure. Body mass index 30.2 kg/m2. Ultrasound examination revealed a large tumor in the left retroperitoneal space. Laboratory testing of blood, urine was performed, findings were unremarkable. According to the data of magnetic resonance imaging, the left kidney was transformed into a large cystic solid formation, measuring 30.5 х 17.5 х 17.0 cm, heterogeneously accumulating a contrast agent with a solid component. Patient was admitted to the urology department for surgical treatment. We performed radical nephrectomy on the left with thoracolumbar laparotomy access on the left with resection of the 10th rib, resecting the renal tumor with the adrenal gland, total weight of the complex was 10.7 kg. The histological structure was determined as poorly differentiated renal carcinoma with invasion of the perinephric tissue. In the adrenal gland, fields of fresh erythrocytes with an admixture of tumor tissue were noted. Examined lymph node tissue was completely replaced by tumor cells. Postoperative period was characterized by episodes of dynamic intestinal obstruction. The patient was discharged from the department in a satisfactory condition on the 13th day after the operation, but died 1.5 months after discharge, the cause of death has not been established, as no autopsy was performed. Thus, the size of the tumor is not a contraindication to surgical treatment, which improves the survival rate of patients with malignant renal tumors.
Central renal cell carcinoma: a diagnostic dilemma
Authors: Mugialan P. , Christopher L.K.S. , Khairul Asri M. G. , Jagwani A.
Published: November 2021

Centrally Located renal tumor poses a diagnostic challenge to differentiate between renal cell carcinoma and transitional cell carcinoma. Imaging alone is not sufficient to make the diagnosis, some invasive diagnostic investigations are required to ascertain the diagnosis. We present a 60 years old gentleman, who presented dyspepsia and further investigation by contrasted CT kidney revealed a centrally located right renal tumor. Before making a management decision, we performed the right renal biopsy of the tumor which turns out to be a renal cell carcinoma. Henceforth, we performed a robotic-assisted laparoscopic right nephrectomy. A renal biopsy, in this case, assisted to decide only radical nephrectomy instead of radical nephroureterectomy which has higher associated morbidity. Thus, it is important to make confirm by tissue biopsy before deciding on surgery in case of the central renal tumor as this prevents subjecting a patient to under-or overtreatment.
Review of the article "Central renal cell carcinoma: a diagnostic dilemma"
Authors: Perlin D. V.
Published: November 2021

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Irene Joliot-Curie, Frederic Joliot-Curie
Authors: Karyakin O. B.
Published: November 2021

Irene Joliot-Curie is the daughter of Marie Curie, a double Nobel Prize-winner. In 1925, Irene Curie became Doctor of Science.

In 1926, Irene married her colleague Frederic Joliot, an assistant at the Radium Institute. With him, she continued experiments with various chemical elements. In some of these experiments, Irene and Frederic performed bombardment of boron, and aluminium with alpha particles, thereby producing new chemical elements. These new elements were radioactive: aluminum became radioactive phosphorus, while boron became a radioactive isotope of nitrogen. Within a short time, Joliot-Curie created many new radioactive elements. In 1935, Irene and Frederic Joliot-Curie were jointly awarded the Nobel Prize for Chemistry for their artificial creation of new radioactive elements Working with uranium in the late 1930s, Irene Joliot-Curie made several important discoveries and came close to the discovery of uranium decay, when bombarded with neutrons.

Jean Frederic Joliot was born in Paris, in the family of a prosperous merchant Henri Joliot and Emilia (Roederer) Joliot, who came from a wealthy Protestant family from Alsace.

Frederic obtained his Doctor of Science degree in 1930 for a thesis on the electrochemistry of radioactive polonium. Having received the Nobel Prize in 1935 together with his wife, 35-year-old Frederick still remains the youngest Nobel Laureate in Chemistry.

The discoveries and achievements of the Joliot-Curie family laid the foundation for further research in nuclear physics, chemistry, and nuclear medicine. Without their discoveries, it is impossible to imagine modern science and everyday life.
Experience of using 1st line combination immunotherapy in patients with metastatic renal cell carcinoma
Authors: Kalpinskiy A. S. , Myslevtsev I. V. , Andrianov A. N. , Nyushko K. M. , Golovashchenko M. P. , Vorobiev N. V. , Chertkova Ya. L. , Shirukova I. Kh. , Usanova E. Yu. , Alekseev B. Ya.
Published: November 2021

The study objective is to evaluate effectiveness and tolerability of 1st line combination immuno-oncological therapy with nivolumab and ipilimumab in patients with metastatic renal cell carcinoma (mRCC) in clinical practice.

Materials and methods. The study included 38 patients with mRCC who received combination immunotherapy between July of 2019 and September of 2021. Median follow-up duration was 8 (2-25) months. Mean age of the patients was 58.3 (20-85) years. Previously 22 (57.9 %) patients underwent surgical treatment. Unfavorable physical status 2-3 per the ECOG scale was observed in 10 (26.3 %) patients. Clear-cell type of renal cell carcinoma was diagnosed in 34 (89.6 %) patients, non-clear-cell types in 4 (10.4 %). Sarcomatoid component in the tumor was detected in 8 (21.0 %) patients. G3-4 mRCC variant was verified in 16 (42.1 %) patients. Poor prognosis per the IMDC (International Metastatic Renal Cell Carcinoma Database Consortium) scale was identified in 16 (42.1 %) patients, intermediate -in 20 (52.6 %) patients. All 4 administrations of combination immunotherapy were received by 29 (76.3 %) patients.

Results. For median follow-up duration of 8 (2-25) months, 23 (60.5 %) patients continue treatment, 15 (39.5 %) completed therapy with nivolumab and ipilimumab due to various reasons including progression in 11 (28.9 %), death in 2 (5.3 %), intolerable toxicity in 2 (5.3 %) cases. Median duration of combination immunotherapy was 9 (2-24) months. Subsequent antitumor therapy was administered to 3 (7.9 %) patients. During induction course immune-mediated adverse event (grade III-IV hepatitis) developed in 3 (7.9 %) patients. Adverse events were observed in 81.6 % of patients, including grade III-IV in 23.7 % of patients. Objective response was observed in 44.8 % of cases, complete response in 5.3 % of cases, partial response in 39.5 % of cases; controlled disease was achieved in 84.3 % of patients. Median progression-free survival and overall survival were 8 months.

Conclusion. In our study despite large number of patients with poor prognosis and poorly differentiated tumors, 64.0 % of patients are alive and 60.5 % of patients continue treatment without disease progression after 18 months of combination immunotherapy. Progression-free survival was significantly affected by sarcomatoid component in the tumor, number of unfavorable factors per the IMDC scale, best response per RECIST 1.1; overall survival was significantly affected by sarcomatoid component in the tumor, sum of measurable lesions, number of unfavorable factors per the IMDC scale, best response per RECIST 1.1, and presence of symptomatic metastases in the brain.
The clinical aspects of peritonitis developing after cystectomy
Authors: Krasny S. A. , Shishlo I. F.
Published: November 2021

Background. Surgical morbidities of radical cystectomy, which are, as a rule, complicated intraabdominal infections, appear to be the main causes of repeated surgeries and fatal outcomes. The elimination of the infection Indus and an-timicrobic therapy are the currently accepted standard of treatment for postoperative peritonitis in cancer urology, as well as in general surgery hospital.

Objective: defining the most reasonable option of surgical aid for peritonitis developing after cystectomy.

Materials and methods. In the time period from 2000 through 2014, 58 cancer patients with postoperative peritonitis developing after cystectomy received indoor treatment at N.N. Alexandrov Republican Research and Practical Center for Oncology and Medical Radiology. Their mean age was 64.9 years, the range 44-90 years, 53 (91.4 %) of them being male. Primary urinary bladder cancer was present in 51 (87.9 %) patients. Peritoneal infection was microbiologically verified in 57 (98.3 %) patients. Each case of fatal outcome was associated with ineffective treatment of peritonitis. Depending on the intraoperative findings (presence or absence of a hollow organ defect) and the surgical approach undertaken (obstructive resection or operation maintaining the continuity of the intestinal and/or urinary tract), the patients were stratified into three groups: group 1 (n = 28), group 2 (n = 20) and group 3 (n = 10). There were no significant differences in the basic parameters specifying peritoneal infection severity between the patients of groups 1 and 2 vs group 3 (p >0.05).

Results. Overall mortality amounted to 25.9 %, 15 patients died. Among the 28 (48.3 %) patients (group 1) who underwent obstructive elimination of the peritonitis focus by means of urointestinal reservoir ablation, resection of small or large intestine with ileo- or colostomy, 6 patients died, mortality 21.4 %. In the 10 (17.2 %) patients (group 3) who succeeded in preserving the urinary conduit or continuity of the bowels by anastomosis defect closure, resection of enteroentero-anastomosis or urointestinal reservoir with repeated anastomosing or defect closure, mortality was higher (60 %) (p = 0.045); 6 patients died.

Conclusion. The most effective option of surgical treatment of postoperative peritonitis developing after cystectomy is obstructive reoperation on the bowels and urinary tracts: compared with the intervention consisting in preserving the urinary conduit and/or continuity of the intestinal tract, this type of surgery caused a 2.8-fold lower mortality.
Novel treatment possibilities of invasive aspergillosis
Authors: Klyasova G. A.
Published: November 2021

Invasive aspergillosis is the leading fungal infection in patients with hematological malignancies. The review represents the incidence of invasive aspergillosis in different groups of patients, risk factors for its development, treatment options, including the new drug isavuconazole.
Prevention and treatment of thrombosis in cancer and oncohematological patients
Authors: Somonova O. V. , Elizarova A. L. , Davydova T. V.
Published: November 2021

The purpose of the review is to highlight the current possibilities for the prevention and treatment of venous thrombotic complications in patients with cancer.

The data of 52 scientific sources published in the Russian and foreign press in 1997–2020 are considered.

Cancer patients are at high risk of thrombotic complications, which worsen the outcome of anticancer treatment and are one of the leading causes of death. Thrombosis in an oncological patient increases the risk of death by 30 times, which is associated with fatal thromboembolism and a more aggressive course of the disease. The leading role in the pathogenesis of thrombotic complications is played by disorders in the hemostasis system caused both by the tumor itself and by therapy. Low molecular weight heparins are considered the basis for specific prophylaxis of thromboembolic complications in cancer patients. The use of low molecular weight heparins after surgery and during chemotherapy effectively reduces the incidence of venous thrombosis. Direct oral anticoagulants are promising drugs for oral administration and are indicated as one of the treatment options for patients with tumor-associated thrombosis with a low risk of bleeding and no drug interactions with ongoing systemic chemotherapy.
Polymorphism of ABO*O alleles and its clinical significance
Authors: Golovkina L. L. , Kalandarov R. S. , Pshenichnikova O. S. , Surin V. L. , Stremoukhova A. G. , Pushkina T. D. , Atroshchenko G. V. , Kalmykova O. S. , Khasigova B. B.
Published: November 2021

Background. 62 ABO*O alleles of the ABO system are known. Some ABO*O alleles may be accompanied by the presence of residual A-glycosyltransferase activity in people of group O, which may lead to errors in determining the blood group. This confirms the important clinical significance of the ABO*O allele polymorphism. Knowledge of ABO*O gene polymorphisms and their prevalence contributes to the prevention of errors in determining the blood group of the ABO system.

Objective: to study allele variants of the ABO*O gene in Russians.

Materials and methods. The blood samples of 14,000 people were examined. The blood group was determined using anti-A, anti-Aweak, anti-B, lectin (anti-A1) and gel cards, as well as by cross-sectional method using standard red blood cells of O, A, and B groups. In one patient, the method of adsorption-elution with cold elution was used to identify a weak variant of antigen A, and the method of thermal elution was used to eliminate antigen- blocking plasma factors. Molecular determination of ABO*O alleles was performed in 130 individuals by polymerase chain reaction with sequence- specific primers and Sanger direct sequencing.

Results. 13 allelic variants of the ABO*O gene were identified (10 with a typical deletion of c.261delG / N and 3 nondeletional alleles with polymorphism c.802G>A). Deletion alleles of ABO*O.01 were found in 92.85 % of the examined patients, nondeletion alleles of АВО*О.02 group – in 7.15 % of cases. The ABO*O.01.01 allele was detected with a frequency of 67.14 %, other deletion alleles – much less frequently: ABO*O.01.02 and ABO*O.01.11 – 5.71 %, ABO*O.01.26 – 5.00 %, ABO*O.01.12 – 4.30 %, ABO*O.01.13 and ABO*O.01.44 – 1.43 %, ABO*O.01.05, ABO*O.01.46, ABO*O.01.68 – 0.71 % each. Non-deletional alleles were found with the following frequencies: ABO*O.02.01 – 4.3 %, ABO*O.02.03 allele – 2.14 %, ABO*O.02.02 – 0.71 %. All individuals with the O group with the nondeletional allele had the Oαβ group, except for one patient (with the ABO*O.01.02 O.02.02 genotype), who had the Oβ group.

Conclusion. For the first time, the immunogenetic characteristics of Russians are given according to ABO*O genes. Erythrocyte genomics helps to resolve the ambiguity of serological methods results and allows understanding mechanisms of different phenotypes formation. For the correct definition of natural isohemagglutinins and weak antigens variants should be used at least two different serological methods.
Key issues of patient safety during anticancer drug treatment in a day hospital and outpatient setting
Authors: Fedenko A. A. , Kolomeytseva A. A. , Artemova V. O.
Published: November 2021

Background. In the context of the ongoing COVID-19 pandemic, the vector of healthcare development is aimed at minimizing contacts among citizens, which is especially important for cancer patients, given the immunosuppression caused by cytostatics.

The objective of the review is to present the development prospects of hospital-substituting technologies for drug antitumor treatment. Two main components are considered that allow effective and safe infusion of anticancer drugs in a day hospital: central venous access devices and infusion pumps, various types of these devices, their safety and experience of use today are described.

Materials and methods. We searched for available literature published in PubMed, Medline, eLIBRARY, Cochrane Library, CyberLeninka, Global.health, etc. 42 sources were found and analyzed, published from 2002 to 2021.

Results. Outpatient anticancer drug treatment is a real alternative to hospital stay, based on many years of world experience. The qualifications level of medical personnel involved in the treatment process should allow early monitoring of various adverse events development. With the ongoing COVID-19 pandemic, it is important to ensure the continuity of the treatment process while minimizing risks to the patient.

Conclusion. With a careful approach and adequate infrastructure availability, drug treatment in a day hospital can reduce the burden on round-the-clock stay hospital and positively affect the patients’ quality of life and their compliance with treatment.
COVID-19 and thrombotic microangiopathy
Authors: Sluhanchuk E. V. , Bitsadze V. O. , Khizroeva J. Kh. , Tretyakova M. V. , Shkoda A. S. , Artyukov O. P. , Tsibizova V. I. , Mishchenko A. L. , Grigorieva K. N. , Gris J.-С. , Elalamy E. , Makatsariya A. D.
Published: November 2021

As shown by numerous studies conducted during the pandemic, the severe course of COVID-19 is accompanied by multiple organ failure. Cytokine storm, hypercoagulation, complement hyperactivation and other arms comprise the overall picture of the pathogenesis of the severe disease course. The frequent diagnosis of multiple microvascular thrombosis in lung, heart, and kidneys, as well as the presence of platelet-fibrin thrombi there and signs of terminal organ damage, suggest a possible involvement of thrombotic microangiopathy (TMA) in the development of multiple organ failure. In this regard, it is especially important to timely diagnose TMA and start pathogenetic therapy. These measures can significantly reduce mortality due to the novel disease. Heparins and direct oral anticoagulants are the mainstay for prevention and treatment of venous thromboembolism in patients with COVID-19, but their effectiveness in the presence of TMA is questionable. It has been proven that anticoagulants use in critically ill patients with COVID-19 for prevention of large vessel thrombosis is effective, but their role in the prevention of microthrombosis is not clear. Here we review the currently available information on thrombotic microangiopathy, as well as a review of literature data describing TMA-like conditions in COVID-19, discuss potential pathophysiology of the condition development and proposed therapeutic approaches.
A Model for Developing a Value Attitude Toward Motherhood among Students
Authors: Tkachenko I.V. , Evdokimova E.V. , Komarova K.Y. , Lisitskaya L.G.
Published: November 2021

The work is aimed at studying the psychological conditions of formation at the subjective level in adolescence of an emotionally positive accepting attitude toward the role of mother. The authors conducted a theoretical and empirical study aimed at exploring the relationship between the perceptions of the phenomenon of motherhood, adolescents’ relationships with their parents, and their attitudes toward their personality. Respondents aged 13-16 years of boarding school №1 “Cossack” of Armavir took part in the study. For the empirical study methods were used: “Perceptions of the ideal parent” (R.V. Ovcharova); PARI technique — “Parent-Child Relations” (E.S. Schaefer, R.K. Bell); Test-questionnaire of self-relation (V.V. Stolin, S.R. Panteleev). The results of the study allow us to state that there is a significant inverse relationship between the excessive emotional distance between parents and their child and the cognitive indicator of ideas about motherhood in boarding school students (-0.248). A similar relationship exists between parents’ excessive emotional distance from their child and their self-acceptance (-0.306), that is, the higher the distance, the lower the adolescent’s self-acceptance. It was proved that the child’s self-acceptance and his or her ideas about an ideal mother are interdependent factors (0, 281). Theoretical analysis of psychological research confirmed that the acceptance of motherhood as a special value is in close connection with the awareness of the meaning of one’s life and varies in its defined value depending on the internal position, experience of intrafamily relationships, internalized benchmarks and ideals. The results of the study formed the basis of the model of formation of the value attitude towards motherhood among students.
PENGEMBANGAN MODEL PEMBELAJARAN GERAK DASAR BOLA VOLI UNTUK SISWA SDN 16 SUNGAI RAYA KABUPATEN KUBU RAYA
Authors: Supriatna Eka
Published: November 2021

Tujuan dari peneltian ini untuk menemukan model-model pembelajaran bolavoli dalam bentuk modul yang sesuai dengan karakteristik siswa sekolah tingkat dasar (SD). Bentuk Desain Penelitian yang digunakan adalah pendekatan pengembangan Research And  Development (R&D) yang dikemukakan oleh Borg dan Gall. Instrumen yang digunakan dalam penelitian ini adalah kuesioner observasi penilaian dari ahli materi bolavoli, kuesioner observasi penilaian ahli media dan kuesioner keefektifkan siswa. Hasil penelitian pengembangan ini adalah sebuah modul pembelajaran gerak dasar bolavoli untuk siswa SDN 16 Sungai Raya Kabupaten KubuRaya. Berdasarkan hasil penilaian ahli materi bolavoli sebesar 84,37% dan ahli media sebesar 88,33% serta nilai uji keefektifan pada kelompok sebesar 87,34 %. Kesimpulan produk sangat baik, sehingga layak digunakan untuk pembelajaran pendidikan jasmani pada siswa  sekolah tingkat dasar di SDN 16 Sungai Raya Kabupaten Kubu Raya.
ONLINE ASSESSMENT OF COGNITIVE ASPECTS IN HIGHER EDUCATION
Authors: Fitriady Gema , Sugiyanto Sugiyanto , Sugiarto Tatok
Published: November 2021

The use of online  assessment s has been widely used in various fields including universities. Research to find the validity of online  assessment s has been conducted and the results are high but the opinions of people who are assessed on the application of online  assessment s have not been carried out. The purpose of this study was to determine the opinion of the person being assessed after conducting an online  assessment . 150 students were selected to be respondents consisting of 126 male and 24 female who were taken by the sampling technique, namely the total sampling. The application of online  assessment s in universities is very suitable. There are several advantages to implementing online  assessment s, including 1) it is preferred by students so that students will be motivated to conduct assessment s; 2) high accessibility and flexibility; 3) rapid feedback. Therefore, the use of online  assessment s in higher education can be done without reducing the quality of the assessment .
PENGARUH LATIHAN CALF RAISE DAN ROPE JUMP TERHADAP PENINGKATAN DAYA LEDAK OTOT TUNGKAI PADA ATLET UKM BOLA VOLLY UMM PROYEKSI POMNAS
Authors: Muzakki Abdurrohman
Published: November 2021

Dalam”permainan”bolaboly”power otot”tungkai sangat”penting bagi”setiap pemain”yang biasanya”digunakan untuk”vertical jump. Tujuan dari”penelitian ini”adalah untuk mengetahui”pengaruh latihan”plyometric calf raise”dan”rope jump. ”Desain penelitian yang”digunakan adalah ”two groupspre-test-post-test design”. Objek penelitian ini adalah Seluruh atlet dari UKM Bola Volly UMM yang diproyeksikan”akan bias untuk mencapai sampai lolos seleksi”POMNAS”sebanyak”30”mahasiswa. Instrument penelitian dalam penelitian ini adalah dengan menggunakan instrumen penelitian”yaitu test Vertical”Jump. ”Pengujian hipotesis menggunakan”uji-t dengan menggunakan”bantuan program”SPSS 16, yaitu dengan”membandingkan mean”antara”pretest dan”post test. Hasil”hipotesis yang”dilakukan”Ha dapat diterima, terjadi”peningkatan secara nyata”dari kedua kelompok eksperimen”yang telah dilatih dirumah”masing-masing terhadap daya”ledak otot tungkai pada”atlet voli UKM UMM, ”terjadi peningkatan secara”nyata pada peningkatan”daya ledak otot tungkai”thitung =”2,74 > 1,551. ”Sehingga dapat disimpulkan”bahwa latihan”calf raise dan latihan rope jump”dari masing-masing kelompok”memberikan sebuah pengaruh yang”signifikan terhadap”peningkatan daya ledak otot”tungkai.