bluuebunny/crossref_metadata_2025 huggingface dataset:
INHIBITORY EFFECT OF CURCUMIN INCORPORATED IN CHITOSAN NANOPARTICLE ON α-AMYLASE AND α-GLUCOSIDASE ACTIVITIES
Authors: WULANDARI WINDA T , TUSLINAH LILIS , APRILLIA ADE Y , ANGGRAENI RATNA , BUDIANI SHAFA A
Published: December 2022

Objective: This research was conducted to determine inhibition activity of curcumin nanoparticles against α-amylase and α-glucosidase enzymes.

Methods: Curcumin nanoparticle was made by ionic gelation method using chitosan as cation, sodium tripolyphosphate as polyanion, and tween 80 as surfactant. Curcumin nanoparticles were tested for inhibitory activity of α-amylase and α-glucosidase enzymes using UV-Vis spectrophotometry at λ= 595 nm and 305 nm, respectively.

Results: Curcumin nanoparticles produced have 198.1 nm of particle size with PdI value of 0.349 and zeta potential value of-8,33 mV. The IC50 value of curcumin nanoparticles against α-amylase was 56.140 ppm, while acarbose was 63.32 ppm. While the IC50 value against α-glucosidase was 3.95 ppm and 4.11 ppm for curcumin nanoparticles and acarbose, respectively.

Conclusion: It can be concluded that curcumin nanoparticles have great potential as antihyperglycemic by inhibiting α-amylase and α-glucosidase enzymes.
IN SILICO STUDY OF 12 PHYTOSTEROL COMPOUNDS IN MORINGA (MORINGA OLEIFERA LAMK.) SEED OIL ON 5Α-REDUCTASE ENZYME INHIBITION ACTIVITY AS ANTI-ALOPECIA
Authors: KORASSA YULIUS BAKI , SAPTARINI NYI MEKAR , MUSTARICHIE RESMI , HENDRIANI RINI , TJITDA PUTRA JIWAMURWA PAMA
Published: December 2022

Objective: This study aimed to determine the interaction of 12 phytosterol compounds in moringa seed oil to the 5α-reductase enzyme (PDB code: 7BW1) as anti-alopecia by in silico.

Methods: The research was conducted using a molecular docking approach using autodock Tools 1.5.6. Data analysis was carried out by looked at the binding affinity values ​​and inhibition constants (Ki) of 12 phytosterol compounds, as well as visualization of amino acid interactions using Biovia Discovery Studio 2021.

Results: 12 Phytosterol compounds had the potential to be a candidate for anti-alopecia medicines based on in silico test simulations using auto dock with high binding affinity values ​​in the range of-11.47 to-12.76 kcal/mol and stable inhibition constants in the range of 1.87. nM–4.30 nM involving hydrogen bonds with Arg179, Tyr178, Arg105, Arg114, Ser177, Tyr98, Glu57, and Tyr91 amino acids.

Conclusion: Ergostadienol compound in moringa seed oil was predicted to be a better anti-alopecia on the inhibition of 5α-reductase enzyme with binding energy value was-11.60 kcal/mol, inhibition constant was 3.17 nM and interaction of amino acid residues on the inhibition of 5α-reductase enzyme was similar with native finasteride ligands namely Glu57 and Tyr91.
ANTIOXIDANT ACTIVITY OF EFFERVESCENT GRANULES FROM KIRINYUH LEAVES (CHROMOLAENA ODORATA (L.) R. M. KING and H. ROB) AND LEAF OF MAREME (GLOCHIDION ARBORESCENS BLUME)
Authors: GUSTAMAN FIRMAN , AMIN SAEFUL , NURDIANTI LUSI , WULANDARI WINDA TRISNA , IDACAHYATI KENI , NURLATHIFAH LETI
Published: December 2022

Objective: The objective of the study was to prepare and evaluate the formulation of the granules effervescent from kirinyuh and mareme leaves as an antioxidant. Methods: The method of making granules with the wet granulation method. The granulation method was used for making granules, meanwhile, the evaluations of the granules was included organoleptic tests, water content, solubility time, pH of the preparation, compressibility, flow time angle of repose and antioxidant activity. Results: The results showed that combination of kirinyuh and mareme as effervescent showed fulfilled all the test criteria, however, demonstrated weak antioxidant activity. Conclusion: The three formulations of effervescent granule preparations from kirinyuh leaves and mareme leaves have very weak antioxidant activity
FORMULATION AND CHARACTERIZATION OF FACIAL SERUM FROM ASTAXANTHIN-BETA CAROTENE NANOEMULSION AS AN ANTIOXIDANT
Authors: NURDIANTI LUSI , WULANDARI WINDA TRISNA , CAHYATI KENI IDA , SETIAWAN FAJAR
Published: December 2022

Objective: The purpose of this study is to make facial serum from astaxanthin-beta carotene nanoemulsion as an antioxidant.

Methods: Nanoemulsions were prepared using Spontaneous Nanoemulsion (SNE) method with a ratio of 1:8:1 for (Sunflower oil): surfactant (Kolliphor® RH40): and co-surfactant (PEG 400). Physical nanoemulsion characterization includes globule size, polydispersity index, zeta potential, visual appearance, pH and entrapment efficiency test. The best results from nanoemulsion were then combined into serum preparations which were then tested for evaluation of the preparations, including organoleptic, homogeneity, viscosity, pH, adhesion and stability test (cycling test).

Results: The results showed that the nanoemulsion of astaxanthin and beta-carotene combination that had been developed had a globule size of<50 nm (with a normal globule size distribution curve), polydispersity index value was less than 0.5, zeta potential was greater than-20 mV and entrapment efficiency was ranging from 80-85%. The results of the preparation evaluation showed that serum astaxanthin-beta carotene nanoemulsion had good results in physical, chemical and stability test during storage. The best serum formula is formula 3 when viewed from the results of the evaluation of the dosage form with an IC50 value of 8.562 ppm with a very strong category as an antioxidant.

Conclusion: Facial serum from astaxanthin-beta carotene is the potential to be an antioxidant.
FORMULATION OF GARGLE FROM TRIGONA SP. PROPOLIS EXTRACT AND ITS ACTIVITY AGAINST STREPTOCOCCUS MUTANS
Authors: KURNIAWANSYAH INSAN SUNAN , CHAERUNISAA ANIS YOHANA , BUDIMAN ARIF
Published: December 2022

Objective: In this research, the formulations of a gargle with Trigona sp. propolis extracts as an alternative of dental caries therapy and test its activity against Streptococcus mutans was carried out.

Methods: The experimental laboratory have been carried out with the following stages of work, material collection and processing, extraction of Trigona sp. propolis by maceration with 95% ethanol, phytochemical screening, determination of minimum inhibitory concentration, formulation of the gargle, activity, contact time and stability test of the formulas.

Results: Phytochemical screening showed that Trigona sp. propolis extracts containing flavonoids, polyphenols, quinones, monoterpenoids and sesquiterpenoids. Minimum inhibitory concentration was 0.25% w/v. The formulation of gargle from Trigona sp. propolis extract were a yellow solution with mint odor and taste of mint and sweet. The antibacterial activity of gargle preparation and formulas from the market as a comparison, showed that the formula with a concentration of 1% w/v gave a significant difference to the market preparation. The formulation of gargle from Trigona sp. propolis extract has good inhibition against bacteria S. mutans with a contact time of 60 seconds and is physically stable during the 35 d of storage time.

Conclusion: The formulation of gargle from Trigona sp. propolis extract is an excellent preparation to be developed in the future in the treatment of dental caries.
FORMULATION AND CHARACTERIZATION OF ZEAXANTHIN NANOEMULSION RADIANCE SERUM AS ANTIOXIDANT
Authors: SETIAWAN FAJAR , RUSDIANA TAOFIK , GOZALI DOLIH , NURDIANTI LUSI , IDACAHYATI KENI , WULANDARI WINDA TRISNA
Published: December 2022

Objective: This study aimed to increase the effectiveness of using zeaxanthin by developed nanoemulsion containing zeaxanthin which was then formulated into radiance serum for topical use.

Methods: Nanoemulsions are made using spontaneous nano emulsification methods/techniques, which are relatively simple technologically because they rely on the right combination of selected surfactants and co-surfactants. The optimization of the formula was carried out starting from determining the oil: surfactant: co-surfactant phase ratio and concentration of zeaxanthin. Nanoemulsion characterization in the form of physical characterization includes organoleptic tests, globule size and polydispersity index, zeta potential, pH and entrapment efficiency tests. The best results from nanoemulsion were then combined into serum preparations which were then tested for evaluation of the preparations, including organoleptic, homogeneity, viscosity, pH, spreadability, and antioxidant test.

Results: The results showed that the developed zeaxanthin nanoemulsion had a globule size in the range of 20-24 nm (with a normal globule size distribution curve), polydispersity index value of less than 0.3, zeta potential greater than (-20) mV and entrapment efficiency ranging from 80-85%.

Conclusion: The results of the evaluation showed that the serum radiance of zeaxanthin nanoemulsion had good physical, chemical and stability properties during storage with an IC50 value of zeaxanthin less than 50 ppm.
NADES EXTRACT OF GEDONG MANGO LEAVES AND MULBERRY LEAVES IN SPRAY GEL AS A SUNSCREEN
Authors: RIZKIYAN YAYAN , SUHARYANI INE , FALYA YUNIARTI , AMELIA RENNY , NUH MUHAMMAD , SULASTRI LELA , INDAWATI IIN
Published: December 2022

Objective: This study's purpose was to formulate a spray gel containing the combination extract of gedong mango leaves and mulberry leaves as a sunscreen preparation.

Methods: Each leaf was extracted by Natural Deep Eutectic Solvent-Maceration Assisted Extraction (NADES-MAE) method. The extract (gedong mango and mulberry leaves) formulated in Carbopol Spray Gel/GM-CarSG) in a ratio of GL and ML were 3:0.5 (GM-CarSG 1); 3:3 (GM-CarSG 2); and 3:6 (GM-CarSG 3). Furthermore, the spray gel was evaluated, and the SPF value was determined.

Results: The physical appearance, spreadability, pH, and viscosity of GM-CarSG 1, GM-CarSG 2, and GM-CarSG 3 meet the requirements. In addition, the three preparation have a sunscreen activity, with the SPF value of GM-CarSG 1, GM-CarSG 2, and GM-CarSG 3 being 2.08+0.03; 2.78+0.05; and 3.53+0.04, respectively.

Conclusion: The results showed that the combination of GL and ML extract is potentially used as a sunscreen in spray gel preparation. The best formulation is GM-CarSG 3, which has the highest SPF value among them.
IN SILICO STUDY OF BIOACTIVE COMPOUNDS FROM SUNGKAI (PERONEMA CANESCENS) AS IMMUNOMODULATOR
Authors: RAHARDHIAN MUHAMMAD RYAN RADIX , SUSILAWATI YASMIWAR , MUSFIROH IDA , FEBRIYANTI RADEN MAYA , MUCHTARIDI  , SUMIWI SRI ADI
Published: December 2022

Objective: This study aims to predict a bioactive compound from Peronema canescens (PC) with mechanisms inhibitor interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α) potential as an immunomodulatory using in silico approach.

Methods: Autodock 4 was used to accomplish computer-assisted drug design with molecular docking simulation to discover binding energy, inhibition constant, and interactions with an amino acid in bioactive compounds from PC against IL-6 and TNF-α receptors. Lipinski predicts the drug-likeness of a bioactive compound for the oral route of administration. ADMET profiling of bioactive compounds to predict pharmacokinetic properties with pkCSM ADMET.

Results: The results showed that the best binding energy, inhibition constant, and interactions with an amino acid of peronemin C1 against IL-6 and TNF-α receptors were (-7.19 kcal/mol; 5.39 nM; Arg 179, Arg 182, Gln 175), and (-8.86 kcal/mol; 320.42 nM; Tyr 119, Tyr 59, and Gly 121), respectively. All bioactive compounds from PC met Lipinski's rule of five requirements for oral administration. ADMET prediction results all bioactive compounds from PC are non-mutagenic, except peronemin D1 is mutagenic.

Conclusion: The peronemin C1 bioactive compounds from PC have good immunomodulatory potential, effectively inhibiting human IL-6 and TNF-α receptors using in silico approach.
Perspective of Multimodal Discourse Analysis: A Case Study of The Big Bang Theory
Authors: Qingqing Wu
Published: December 2022

This paper, taking the subtitle translation of an American comedy The Big Bang Theory as the object of the study, selects the subtitle translations of some typical clips. Based on the integrated framework of multimodal discourse analysis proposed by Professor Zhang Delu, the subtitle translation is analyzed from four levels including culture, context, content, and expression. This paper concludes that multiple modalities interact each other in complementary ways. The interactions between multiple modalities help viewers better understand subtitle translation. Subtitle translation, together with other modalities, helps viewers grasp the plot of the TV series. The author hopes that this study can provide some reference for subtitle translators.
Critical Analysis of the Law Relating to Cyber Crime
Authors: Kumar Ayush
Published: December 2022

Abstract: The Cyber Crime is most popular Crime in the world the Cyber Criminals Crimes are the Committed day by day .This Crime commit the Computer and Internet in this Crime Criminals are hacking the Computer system, Mobile like that Hacking virus ,Worm attacks, DOS attack etc. The personal data are Theft Like that Bank account detail, e-mail, Mobile messages .The computer as a weapon using the computer system to commit real world Crimes like Cyber terrorism, IPR(Intellectual property infringing) contravention, credit card frauds, EFT (Electronic fund transfer) Frauds, Pornography etc. The Cyber Criminals activities to the internet are termed as Cyber Crimes with the increasing popularity of online activity like that online banking and online Sopping In this term hearing the news day by day. The Cyber Crime law of The Cyber Criminals can involves the Crimes activity like that Theft, fraud, forgery, scandal and mischief all of which are the object to the IPC. The Abuse of the computer has also given birth to a scale of new generation Crimes that are addressed by the information technology .The Cyber law is a term used to explain legal issues affined to use of communications technology, particularly cyberspace the Internet.
Towards a general framework of Randomized Benchmarking incorporating non-Markovian Noise
Authors: Figueroa-Romero Pedro , Modi Kavan , Hsieh Min-Hsiu
Published: December 2022

The rapid progress in the development of quantum devices is in large part due to the availability of a wide range of characterization techniques allowing to probe, test and adjust them. Nevertheless, these methods often make use of approximations that hold in rather simplistic circumstances. In particular, assuming that error mechanisms stay constant in time and have no dependence in the past, is something that will be impossible to do as quantum processors continue scaling up in depth and size. We establish a theoretical framework for the Randomized Benchmarking protocol encompassing temporally-correlated, so-called non-Markovian noise, at the gate level, for any gate set belonging to a wide class of finite groups. We obtain a general expression for the Average Sequence Fidelity (ASF) and propose a way to obtain average gate fidelities of full non-Markovian noise processes. Moreover, we obtain conditions that are fulfilled when an ASF displays authentic non-Markovian deviations. Finally, we show that even though gate-dependence does not translate into a perturbative term within the ASF, as in the Markovian case, the non-Markovian sequence fidelity nevertheless remains stable under small gate-dependent perturbations.
About the ethnonym “Crimean Tatars”: analysis of historical sources
Authors:   Marjani Institute of History of the Tatarstan Academy of Sciences, Kemal El’vira R.
Published: December 2022

The article is devoted to the issue of self-designation of the Crimean Tatars. Among the Crimean Tatar people discussions have been going on for a long time on the topic of the true ethnonym: Crimeans or Crimean Tatars. Defenders of the “Crimeans” version claim that this ethnonym is historical and more accurate. Is it so? We analyzed historical sources and described the results in the article.
Too much power or no power: when does intermediary’s power result into better wine and happier farmers?
Authors: Xhoxhi Orjon , Imami Drini , Hanf Jon , Gjokaj Ekrem
Published: December 2022

The study analyzes the trading relationship performance between farmers and intermediaries and the factors shaping it, with a focus on intermediary’s power, based on a structured survey of vineyard farmers in Kosovo. Confirmatory factor analysis is employed to develop measures for the study latent variables, and ordinary least squares regression is used to test the hypothesis. To further validate the results, machine learning (i.e. random forest) is used to model the factors affecting the relationship performance between farmer and intermediary. The results show that when the intermediary has considerable (excessive) power, it leads to low trading relationship performance with farmers. Also, when the intermediary has little power, the relationship performance with farmers behaves in a similar way. The main contribution of this paper is to further illuminate the debate on the role of power in business-to-business relationships, in that it points out an alternative explanation; stating that there is an optimal level zone that power needs to exist, in order to achieve above average trading relationship performance. Outside this zone, either low or excessive/high intermediary’s power results in poor relationship performance.
BNCC, voguing, gênero e sexualidade: reflexões a partir de uma experiência na formação docente em dança no estágio supervisionado
Authors: Gabardo Junior Jair Mario , Martins dos Reis Lui , De Paula Fedalto Antony Vinicius
Published: December 2022

Este artigo tem por objetivo discutir uma experiência com a docência em Dança no Estágio Supervisionado Obrigatório IV, destinado ao contexto da Educação formal para a etapa do Ensino Médio e vinculado a um curso de bacharelado e licenciatura em Dança. Para tanto, apresentamos algumas reflexões a partir da nossa experiência educativa como sujeitos professores em formação e docente orientador do processo, cuja vivência ocorreu de forma remota com uma turma de um colégio da rede pública de Curitiba/PR. O foco, contudo, está nos saberes selecionados a partir não apenas dos interesses inerentes aos autores, mas também dos desafios de problematizar questões de gênero, sexualidade e promoção da cidadania de sujeitos LGBTQIA+ nesta última etapa da Educação Básica. A ação artístico-pedagógica buscou aproximar os sujeitos estudantes da escola da cultura ballroom por intermédio da dança voguing, atravessada em especial pelas lentes dos Estudos Culturais. Como possíveis respostas, reconhecemos a potência do saber em Dança como disparador de novas corporeidades na sala de aula e a urgência em desvelar na atual BNCC meios para ampliar os debates sobre currículo, arte e diversidade no Ensino Médio.
“O menino que brincava de ser”: Drama virtual, infâncias dissidentes e formação de professores(as) de teatro
Authors: Fazzioni Mateus Junior , Pereira Diego de Medeiros
Published: December 2022

Este texto trata de uma reflexão acerca de um processo de Drama - abordagem para o ensino e experimentação do teatro - desenvolvido com estudantes de Licenciatura em Teatro, cuja narrativa buscava tensionar as construções sociais de gênero e sexualidade impostas às crianças. Mediante uma experimentação virtual, diferentes estratégias dessa abordagem foram experimentadas e discussões acerca do modo como se lida com crianças dissidentes no ambiente escolar foram possibilitadas. Defende-se a necessidade de que os(as) profissionais da educação estejam preparados(as) para lidarem com os corpos e subjetividades dessas crianças e se vê no Drama uma proposta de fazer teatral que considera as vozes dos(as) participantes no processo de criação.
Ownership structure and agency costs: Evidence of emerging economy
Authors: Turshan Mohammed Nader , Karim Naser Abdel
Published: December 2022

The core objective of this study is to investigate the effect of ownership structure components on agency costs for 26 firms listed on the Palestine Exchange (PEX) between 2010 and 2019. The fixed-effects model was used to analyze cross-sectional data over time (panel data), and the multiple linear regression analysis was used to test the study hypotheses. The study found a positive, statistically significant effect of both board ownership and ownership concentration on agency costs, this indicates that whenever the ownership of board members in the firms listed on the PEX increases, leads to an increase in agency costs in these firms, reducing the performance of the firm, motivating management to seek to secure its interest and not to maximize the value of the firm. Similarly, whenever ownership increases in the hands of a few investors in the firms listed on the PEX, this leads to an increase in agency costs in these firms, and this relationship may be due to the majority’s ability to exploit the company’s capabilities for their goals and interests. Another main result of the study was a negative, statistically significant effect of institutional ownership on agency costs in the firms listed on the PEX.
The effect of exchange rate volatility on economic growth
Authors: Yensu Joseph , Nkrumah Seth Kofi , Amankwah Samuel , Ledi Klenam Korbla
Published: December 2022

This study aimed to investigate the connection between exchange rate volatility and economic growth in Ghana. The study applied descriptive statistical analysis, regression analysis, and correlation analysis to analyze the data spanning from the year 2000 to 2020. The study discovered that the actual exchange rate exhibits clustering volatility, which means that a period of large (small) fluctuations in the exchange rate shock is followed by large (small) fluctuations over a longer time. Negative correlations were found between exchange rate volatility and trade openness, government expenditure, money supply, foreign direct investment (FDI), output, and domestic credit to the private sector, among others. It was determined that exogenous variables such as terms of trade, domestic money supply, government expenditure, and capital flows affected exchange rate volatility over the long term, which was consistent with the findings of other studies (Rasheed, Ishaq, & Malik, 2022; Barguellil, Ben-Salha, & Zmami, 2018). The study also indicated that exchange rate volatility had a negative effect on economic growth. In all, most of the effects are felt at the end rather than in the short run. The government should encourage the diversification of industries by encouraging industrialization to boost export as a way of offsetting our huge imports. There must be a tightening of the monetary policy through raising interest rates to keep inflation at bay.
BIOMOLECULAR SOLUTION X-RAY SCATTERING AT n2STAR BEAMLINE
Authors: GÖCENLER Oktay , YENİCİ Cansu Müşerref , KAHRAMAN Kerem , BÜYÜKDAĞ Cengizhan , DAĞ Çağdaş
Published: December 2022

Small angle X-ray Scattering (SAXS) is a method for determining basic structural characteristics such as the size, shape, and surface of particles. SAXS data can be used to generate low resolution models of biomolecules faster than any other conventional experimental structural biology tool. SAXS data is mostly collected in synchrotron facilities to obtain the best scattering data possible however home source SAXS devices can also generate valuable data when properly optimized. Here, we examined sample data collection and optimization at home source SAXS beamline in terms of the concentration, purity, and duration of data acquisition. We validated that high concentration, monodisperse and ultra pure protein samples obtained by size exclusion chromatography are necessary for generating viable SAXS data using a home source beamline. At least one hour is required to generate a feasible model from SAXS data, although longer data collection times do not always translate to higher resolutions. We show that with small optimizations during data collection and analysis SAXS can characterize properties such as oligomerization, molecular mass, and overall shape of particles in solution under physiological conditions.
The role of oceanic currents in the dispersal and connectivity of the mangrove Rhizophora mangle on the Southwest Atlantic region
Authors: Madeira André Guilherme , Tsuda Yoshiaki , Nagano Yukio , Iwasaki Takaya , Zucchi Maria , Kajita Tadashi , Mori Gustavo
Published: December 2022

Dispersal is a crucial mechanism to living beings, allowing them to
reach new resources such that populations and species can explore new
environments. However, directly observing the dispersal mechanisms of
widespread species can be costly or even impracticable, which is the
case for mangrove trees. The influence of ocean currents on the
mangroves’ propagules’ movement has been increasingly evident; however,
few studies mechanistically relate the patterns of population
distribution with the dispersal by oceanic currents under an integrated
framework. Here, we evaluate the role of oceanic currents on dispersal
and connectivity of Rhizophora mangle along the Southwest
Atlantic. We inferred population genetic structure and migration rates
based on single nucleotide polymorphisms, simulated the displacement of
propagules along the region and tested our hypotheses with Mantel tests
and redundancy analysis. We observed a two populations structure, north
and south, which is corroborated by other studies with Rhizophora
and other coastal plants. The inferred recent migration rates do not
indicate gene flow between the sampled sites. Conversely, long-term
migration rates were low across groups and contrasting dispersal
patterns within each one, which is consistent with long-distance
dispersal events. Our hypothesis tests suggests that both isolation by
distance and isolation by oceanography (derived from the oceanic
currents) can explain the neutral genetic variation of R. mangle
in the region. Our findings expand current knowledge of mangrove
connectivity and highlight how the association of molecular methods with
oceanographic simulations improve the interpretation power of the
dispersal process, which has ecological and evolutionary implications.
Chromosome-level genome assembly of Pterygoplichthys pardalis reveals genetic basis of extensive invasion
Authors: xia wangxiao , Li Haorong , Liu Yaowen , Jiang Hui , Wu Yonghong , Zhang Yuanwei , Xu Lixian , Gou Xingchun
Published: December 2022

The Amazon sailfin catfish (Pterygoplichthys pardalis), which
belongs to the Loricariidae family, is an invasive species that
has caused massive damage to the ecological environment. However, a
high-quality reference genome for this catfish species has not yet been
reported. Here, we successfully assembled the first chromosome-level
high-quality genome of P. pardalis using data produced from
multiple sequencing platforms. The assembled genome contains 26
chromosomes, with a scaffold N50 of 49.47 Mb. Different evaluation
methods indicated the high connectivity and accuracy genome we got. In
total, 23 859 protein-coding genes were predicted in the genome, 22 169
(92.92%) of which were functionally annotated in public databases.
Phylogenetic analysis showed that P. pardalis was clustered with
all other catfish studied and diverged from their common ancestor 132.5
million years ago. Whole-genome collinearity analysis indicated the
chromosome 6 of P. pardalis was aligned to two distinct
chromosomes in Ameiurus melas, Pangasianodon
hypophthalmus, and Ictalurus punctatus, suggesting the
occurrence of potential chromosomal fusion/fission events. Furthermore,
many immune system-related genes were expanded in the P. pardalis
genome, which may have contributed to their adaptive traits to highly
polluted environments and successful invasion. This study not only
provides insights into the genetic basis of the successful invasion of
P. pardalis, but also provides important data for comparative
genomic analysis of P. pardalis in Siluriformes in the future.
Decannulation in congenital central hypoventilation syndrome
Authors: Dudoignon Benjamin , Ghelab Zina , Bokov Plamen , Teissier Natacha , Micaelli Delphine , Patout Maxime , Hayotte Aurelie , Dauger Stéphane , Delclaux Christophe
Published: December 2022

Rationale: Patients with congenital central hypoventilation syndrome
(CCHS) require long-term ventilation to ensure gas exchange and to
prevent deleterious consequences for neurocognitive development. Two
ventilation modes may be used for these patients depending on their
tolerance, one invasive by tracheostomy and the other noninvasive (NIV).
For patients who have undergone a tracheostomy, transition to NIV is
possible when they meet predefined criteria. Identifying the conditions
favorable for weaning from a tracheostomy it critical for the success of
the process. Objective: The aim of the study was to share our experience
of decannulation in a reference center; we hereby describe the modality
of ventilation and its effect on nocturnal gas exchange before and after
tracheostomy removal. Methods: Retrospective observational study at
Robert Debré Hospital over the past 10 years. The modalities of
decannulation and transcutaneous carbon dioxide recordings or
polysomnographies before and after decannulation were collected.
Results: Sixteen patients underwent decannulation following a specific
procedure for transition from invasive to NIV. All decannulations were
successful. The median age at decannulation was 12.6 [9.7; 15.0]
years. Nocturnal gas exchange was not significantly different before and
after decannulation, while expiratory positive airway pressure and
inspiratory time increased significantly. An oronasal interface was
chosen in two out of three patients. The mean duration of hospital stay
for decannulation was 4.0 [3.0; 6.0] days. Conclusion: Our study
underlines that decannulation and transition to NIV are achievable in
CCHS children using a well-defined procedure. Patient preparation is
crucial to the success of the process.
Data-driven digital twin models for forecasting multi-step ahead profiles of mammalian cell culture performance
Authors: Lee Dong-Yup , Park Seo-Young , Kim Sun-Jong , Park Cheol-Hwan , Kim Jiyong
Published: December 2022

Recently, enormous culture profiles and datasets from biomanufacturing
processes to produce recombinant therapeutic proteins (RTP) such as
monoclonal antibodies (mAbs) could be generated by virtue of the
advancement in process analytical techniques and artificial intelligence
(AI). Thus, now it is highly necessary to develop AI-based data-driven
models (DDMs) and exploit them accordingly in order to further enhance
operational efficiency and accelerate reliable product supply. Since
bioprocess is a complex and dynamic system, DDMs are practical and
particularly useful to describe the intrinsic relationship among
biological and process parameters and cell culture conditions by
capturing inherent patterns and to produce high-quality RTP under
consistent operations as well as to decrease cost and time by predicting
incipient or abrupt faults during the cell cultures. In this work, we
provide the practical guideline for choosing the best DDM on given
mAb-producing Chinese hamster ovary (CHO) cell culture data sets,
enabling us to forecast culture performance such as VCD, and mAb titer
as well as glucose, lactate and ammonia concentrations in real time
manner. Via the case study with 32 fed-batch data sets of CHO cell
cultures, we suggested best combination of model elements including AI
algorithms and multi-step ahead forecasting strategies, for good
prediction in terms of the computational load as well as the model
accuracy and reliability, which is applicable to implementation of
interactive data-driven model within bioprocess digital twins. We
believe this systematic study can help bioprocess engineers to start
developing predictive DDMs with their own data and learn how their cell
cultures behave in near future, thereby making proactive decision
possible.
Environmental drivers of genetic adaptation in Florida corals
Authors: Black Kristina , Rippe John , Matz Mikhail
Published: December 2022

Thermally induced coral bleaching is a major cause of reef decline,
though it could be offset by coral adaptation. Here we used three
complementary approaches to identify which environmental gradients drive
local adaptation in two common Florida corals, Porites astreoides and
Agaricia agaricites. Depth is the most important factor for both
species: each contains three genetically distinct lineages segregated by
depth. Additionally, each lineage harbors genetic variation aligning
with other environmental gradients, though elevated temperature is
typically not one of them. In A. agaricites, nitrogen variation predicts
genetic divergence in the deep and mid-depth lineages, while cold
temperature is the most important driver within the shallow lineage.
Nitrogen and cold are also associated with genetic variation in P.
astreoides, and high temperature was highlighted only once in the deep
lineage of P. astreoides. In both species, lineages don’t share
environment-associated groups of SNPs, indicating that lineages adapt
independently. Overall, the locally available genetic variation in our
two corals species seems unlikely to provide thermally adaptive genetic
variants for future warming. Our results map the environmental gradients
that create the strongest genetic barriers for corals, which could serve
as a guide for reef restoration.
Full-length transcriptomes of brain and ganglia and sex-based differentially-expressed genes involved in growth dimorphism of giant river prawn Macrobrachium rosenbergii
Authors: Liu Dong , Hong Zhenzhen , Gui Lang , Zhao Li , Zhou Wenzong , Wang Yude , Sun Shengming , Li Mingyou
Published: December 2022

The giant river prawn Macrobrachium rosenbergii is an important
aquaculture prawn, showing sexual dimorphism in growth, with males
growing much faster than females. However, the mechanisms controlling
these complex traits are not yet well understood. The nervous system
plays an important role in regulating life functions. This study aimed
to obtain and characterize the full-length transcriptomes of brain and
ganglion in female and male prawns by PacBio RNA sequencing. Based on
the result of PacBio sequencing, transcript’s functional annotation,
transcript factors, and simple sequence repeat analysis, long non-coding
RNAs (LncRNAs) and transposable element predictions were accomplished.
Total 159.1-Gb subreads were obtained and average length was 2,175 bp,
with 93.2% completeness. After clustering and polishing, 84,627 high
quality unigene sequences were produced and annotated by functional
databases. 6,367 transcript factors and 6,287 LncRNAs were predicted.
Illumina sequencing of brains and ganglia extracted from female and male
prawns was carried out. A significant number of differentially expressed
genes (DEGs) were found and confirmed by qRT-PCR analysis. Of the
related 435 genes in protein processing pathways in the endoplasmic
reticula, compared to females, 42 DEGs were detected, and 21/26 DEGs
with up-regulated expression in male prawn brain/ganglion. DEGs in this
pathway are likely to be regulated by multiple LncRNAs in polypeptide
folding and misfolded protein degradation in the different organs and
sexes of the prawn. Our study lays a foundation for understanding the
growth dimorphism controlled by nervous system, and is a valuable
resource for sex-controlled breeding of prawns in the future.
On non-null relatively normal-slant helices in Minkowski 3-space
Authors: Nesovic Emilija , Öztürk Ufuk , Koç Öztürk
Published: December 2022

By using the Darboux frame |?, ?, ?| of a non-null curve lying on a
timelike surface in Minkowski 3-space, where ? is the unit tangent vector of
the curve, ? is the unit spacelike normal vector field restricted to the
curve and ? = ?? ? ?, we define relatively normal-slant helices as the
curves satisfying the condition that the scalar product of the fixed vector
spanning their axis and the non-constant vector field ? is constant. We give
the necessary and sufficient conditions for non-null curves lying on a
timelike surface to be relatively normal-slant helices. We consider the
special cases when non-null relatively-normal slant helices are geodesic
curves, asymptotic curves, or lines of the principal curvature. We show that
an asymptotic spacelike hyperbolic helix lying on the principal normal
surface over the helix and a geodesic spacelike general helix lying on the
timelike cylindrical ruled surface, are some examples of non-null relatively
normal-slant helices in E31.
Global regularity for the 3D micropolar fluid flows
Authors: Alghamdi Ahmad , Gala Sadek , Ragusa Maria
Published: December 2022

The aim of this note is to establish the global regularity of classical
solutions of the 3D micropolar fluid equations for a family of large initial
data with finite energy.
Lehi’s Dream of the Tree of Life: Springboard to Prophecy
Authors: Volluz Corbin T.
Published: December 2022

Lehi’s dream of the tree of life is well known in Latter-day Saint circles. Its relationship to the vision of Nephi (1 Nephi 11-14), however, may not be so well known. This paper examines the proposition that Nephi’s vision was an expansive, prophetic interpretation of Lehi’s dream of the tree of life. An alternate interpretation of Lehi’s dream as a guide to the afterlife is also discussed. Finally, links between Lehi’s dream, the Garden of Eden, and the temple will be considered.
Joseph Smith’s Receipt of the Plates and the Israelite Feast of Trumpets
Authors: Read Lenet Hadley
Published: December 2022

Joseph Smith received the golden plates on the Israelite Day of Remembrance (or Rosh ha-Shanah). Biblical references and interpretation by Jewish sages through the centuries set this day as the day God would remember his covenants with Israel to bring them back from exile. Also called the Feast of Trumpets, on this day ritual trumpet blasts signify the issuance of revelation and a call for Israel to gather for God’s word of redemption. Set at the time of Israel’s final agricultural harvest, the day also symbolizes the Lord’s final harvest of souls. Furthermore, it initiates the completion of the Lord’s time periods, the Days of Awe, and signifies the last time to prepare for final judgment and the Messianic Age. The coming forth of the Book of Mormon is literally fulfilling such prophecies of the day.
A Short Addition to Length: Some Relative Frequencies of Circumstantial Structures
Authors: Stubbs Brian D.
Published: December 2022

In previous articles I have discussed the nature and prominence of certain linguistic structures in the Book of Mormon that are typical of ḥāl-clauses translated from Hebrew or Egyptian. This article compares the frequencies of those structures in three works produced through the instrumentality of Joseph Smith: the Book of Mormon, the Doctrine and Covenants, and History of the Church of Jesus Christ of Latter-day Saints, only the first of which is a translation from an ancient Near Eastern language. The results of this preliminary investigation into styles and these linguistic structures as found in these three works are worth noting.
Å utvikle digital kompetanse gjennom refleksjon over kroppslige og emosjonelle erfaringer – en lærerutdanners erfaringer
Authors: Ørbæk Trine
Published: December 2022

I denne artikkelen stilles det spørsmål om hvordan refleksjoner over kroppslige og emosjonelle erfaringer kan ha betydning for utvikling av lærerutdanneres digitale kompetanse. Datamaterialet i denne autoetnografiske studien er refleksjonsnotater fra en lærerutdanners digitale undervisning våren 2021, som anvendes til å belyse forskningsspørsmålene: Hvilke kroppslige og emosjonelle erfaringer kommer til uttrykk når en lærerutdanner underviser digitalt? Hvilken betydning har disse kroppslige og emosjonelle erfaringene for hennes valg i undervisningsøyeblikket? Og hvilken betydning kan refleksjoner over kroppslige og emosjonelle erfaringer ha for utvikling av lærerutdanneres digitale kompetanse? Ved å anvende Deweys forståelse av erfaring og Fuchs’ begreper kroppslig resonans og mellomkroppslig samspill får analysen fram hvordan det å undervise digitalt skaper affekter og emotiver som får betydning for hvilke valg lærerutdanneren gjør i undervisingsøyeblikket, for relasjonen til studentene og for lærerutdannerens opplevelse av sin egen undervisning. Funnene viser også at refleksjoner over affektive og emotive erfaringer fra digital undervisning bidrar til å synliggjøre lærerutdannerens implisitte profesjonskunnskap, og med det gjøre erfaringene betydningsfulle i lærerutdannerens utvikling av egen undervisningspraksis både digitalt og på campus.
ENGLISH ABSTRACT
Developing digital competence through reflection on bodily and emotional experiences – a teacher educator’s experienceThis article asks how reflections on bodily and emotional experiences can have impact on the development of teacher educators’ digital competence. The data material in this autoethnographic study are reflection notes from a teacher educator’s digital teaching in the spring of 2021, which are used to illuminate the research questions: What bodily and emotional experiences are expressed when a teacher educator teaches digitally? What significance do these bodily and emotional experiences have for her choices at the moment of teaching? And what significance can reflections on bodily and emotional experiences have for the development of teacher educators’ professional digital competence? By applying Dewey’s understanding of experience and Fuchs’ concepts of bodily resonance and interbody interaction, the analysis reveals how digital teaching creates affective and emotive experiences that have an impact on the choices the teacher educator makes at the time of teaching, for the relationship with students and for the teacher educator’s experience of her own teaching. The findings also show that reflections on affective and emotive experiences from digital teaching help to highlight the teacher educator’s implicit professional knowledge and thereby make the experiences significant in the teacher educators’ development of their own teaching practice digitally and on campus.
Dampak Sistem Pembayaran Non-Tunai Terhadap Permintaan Uang Kartal di Indonesia
Authors: Herlina Deswita , Firdaus Safira
Published: December 2022

The stability of the demand for money is important to maintain the value of therupiah. This stability is seen in terms of the amount of currency and the ability ofmoney to fulfill all transactions in a short time. The use of non-cash money canhelp speed up the processing of financial transactions, but on the one hand it canhave an impact on changes in the demand for currency, which in turn affects thestability of the money supply. For this reason, it is necessary to conduct researchon the impact of using non-cash money on the demand for currency in Indonesia.This study analyzes the impact of non-cash payments using cards (APMK) on thedemand for currency in Indonesia for the 2014-2017 period. The analytical toolsused in this study are Vector Autoregression (VAR) to determine causality,Impulse Response Function (IRF) and Variance Decomposition (VD). The resultsshowed that the increase in the use of card-based non-cash money had an impacton reducing the demand for money in Indonesia in the 2014-2017 period. Thenon-cash money shock has an impact on the shock of changes in the demand forcurrency.
Analisis Modal Manusia, Investasi, dan Teknologi terhadap Pertumbuhan Ekonomi Sumatera Barat
Authors: Wulandari Azizah Putri , Ariusni Ariusni
Published: December 2022

This study aims to identify and analyze. (1) What is the impact of labor on theeconomic growth of West Sumatra? (2) What is the impact of human capital onthe economic growth of West Sumatra? (3) What is the impact of investment onthe economic growth of West Sumatra? (4) What is the impact of technology onthe economic growth of West Sumatra, and (5) What is the impact of labor,human capital, investment, and technology on the economic growth of WestSumatra? This study is descriptive and inductive using panel data regressionanalysis using a random-effects model (REM) method using time series 2017-2020 taken from 19 district/city across province from related agencies in WestSumatra.The results show that the effects of labor, human capital, investment, andtechnology at the same time had a significant positive impact on WestSumatra's economic growth. In addition, in part, (1) labor has negative andslightly impact on West Sumatra's economic growth, (2) human capital has apositive and significant impact on West Sumatra's economic growth, and (3)investment study on economic growth in West Sumatra that has a positive andslightly impact. West Sumatra. West Sumatra, (4) Technology has a negativeand significant impact on West Sumatra's economic growth. Therefore, labor,human capital, investment, and technology are the most important aspects ofWest Sumatra's economic growth.
Analisis Penyerapan Tenaga Kerja pada Industri Mikro Kecil (IMK) di Kabupaten Padang Pariaman
Authors: Syafrilia Elwita , Marta Joan , Artha Dwirani Puspa
Published: December 2022

This study aims to determine the effect of business capital, total productionvalue, type of place of business, type of indstry and utilization of internettechnology on the labor absorption of micro and small industries in PadangPariaman District. This type of research is descriptive and associative research,the data used is secondary data (cross section) in 2021 obtained from relatedinstitutions. The analytical method used is Poisson regression analysis modelassisted by STATA 16 software. The result show that; (1) business capital has asignificant and positive effect on the labor absorption of micro and smallindustries in Padang Pariaman District; (2) total production value has asignificant and positive effect on the labor absorption of micro and smallindustries in Padang Pariaman District; (3) type of place of business has asignificant and positive effect on the labor absorption of micro and smallindustries in Padang Pariaman District; (4) the type of non metallic mineralsindustry, food industry and other industries have a significant effect on thelabor absorption of micro and small industries in Padang Pariaman District,while the wood industry does not have a significant effect on the laborabsorption of micro and small industries in Padang Pariaman District; (5)utilization of internet technology has a significant and positive effect on thelabor absorption of micro and small industries in Padang Pariaman District.
Pengaruh Pelatihan Pengenalan Diri terhadap Self Esteem Remaja Tunanetra di Panti Sosial Bina Netra Tuah Sakato Padang
Authors: Putri Tasha Dwilamiisa , Rusli Devi
Published: December 2022

Penelitian ini dilakukan untuk mengetahui pengaruh pelatihan pengenalan diri terhadap self-esteem remaja tunanetra di panti sosial bina netra tuah sakato padang. Jenis penilitian ini ialah kuasi eksperimen dengan one group pretest posttest design. Dengan teknik purposive sampling didapatkan 15 subjek. Instrumen yang digunakan ialah Self-Liking dan Self Competence Questionnaires - Revised Version (SLCS-R) oleh Tafarodi & Swann (1995) dengan 16 item pernyataan yang telah diterjemahkan ke dalam bahasa Indonesia. Hasil uji wilcoxon signed berupa Zhitung sebesar - 3.417 dengan Asymp. Sig. (2-tailed) 0,001. Dengan nilai probabilitas sebesar α = 0,05, maka probabilitas Z hitung kurang dari probabilitas yang telah ditentukan (0,001 < 0,05). Sehingga hipotesis diterima atau dapat disimpulkan bahwa terdapat pengaruh pelatihan pengenalan diri terhadap self-esteem remaja tunanetra.