bluuebunny/crossref_metadata_2025 huggingface dataset:
Cell Death and Inflammation: The Role of Mitochondria in Health and Disease
Authors: Picca Anna , Calvani Riccardo , Coelho-Junior Hélio José , Marzetti Emanuele
Published: March 2021

Mitochondria serve as a hub for a multitude of vital cellular processes. To ensure an efficient deployment of mitochondrial tasks, organelle homeostasis needs to be preserved. Mitochondrial quality control (MQC) mechanisms (i.e., mitochondrial dynamics, biogenesis, proteostasis, and autophagy) are in place to safeguard organelle integrity and functionality. Defective MQC has been reported in several conditions characterized by chronic low-grade inflammation. In this context, the displacement of mitochondrial components, including mitochondrial DNA (mtDNA), into the extracellular compartment is a possible factor eliciting an innate immune response. The presence of bacterial-like CpG islands in mtDNA makes this molecule recognized as a damaged-associated molecular pattern by the innate immune system. Following cell death-triggering stressors, mtDNA can be released from the cell and ignite inflammation via several pathways. Crosstalk between autophagy and apoptosis has emerged as a pivotal factor for the regulation of mtDNA release, cell’s fate, and inflammation. The repression of mtDNA-mediated interferon production, a powerful driver of immunological cell death, is also regulated by autophagy–apoptosis crosstalk. Interferon production during mtDNA-mediated inflammation may be exploited for the elimination of dying cells and their conversion into elements driving anti-tumor immunity.
A Case of Prenatally Diagnosed Uhl’s Anomaly with Absent Pulmonary Valve Leaflets and Dysplastic Tricuspid Valve
Authors: Kim Taehong , Ko Hoon , Byun Joung-Hee , Lee Hyoung Doo , Kim Hyungtae , Choi Kwangho , Na Joo-Young
Published: March 2021

Uhl’s anomaly is a very rare malformation of unknown cause, characterized by complete or partial absence of the right ventricular myocardium. The cardiac malformation causes progressive right heart failure, increased right-sided cardiac pressure, massive peripheral edema, and ascites. Patients usually present in infancy and rarely survive to adulthood. Previously, diagnosis was made at post-mortem evaluation, but advances in cardiac imaging now permit diagnosis during fetal life. We report a case of Uhl’s anomaly in a newborn baby imaged at 23 + 3 weeks of gestation by fetal echocardiography. There was an aneurysmally dilated thin-walled right ventricle with hypertrophy of the right ventricular apical muscles, the tricuspid valve was dysplastic, and the pulmonary valve leaflets were absent.
Effects of Exercise in Patients with Obstructive Sleep Apnoea
Authors: Torres-Castro Rodrigo , Vasconcello-Castillo Luis , Puppo Homero , Cabrera-Aguilera Ignacio , Otto-Yáñez Matías , Rosales-Fuentes Javiera , Vilaró Jordi
Published: March 2021

Obstructive sleep apnoea (OSA) constitutes a public health problem, with various systemic consequences that can increase cardiovascular morbidity and mortality as well as increase healthcare expenditure. This review discusses the rationale and effects of using general physical exercise, oropharyngeal exercises, and respiratory muscle training as an adjunctive treatment for patients with sleep apnoea. The recommended treatment for OSA is the use of continuous positive airway pressure, which is a therapy that prevents apnoea events by keeping the airways open. In the last decade, coadjuvant treatments that aim to support weight loss (including diet and physical exercise) and oropharyngeal exercises have been proposed to lower the apnoea/hypopnoea index among patients with OSA. Based on the available evidence, health professionals could decide to incorporate these therapeutic strategies to manage patients with sleep apnoea.
Significance of Parallel Computing on the Performance of Digital Image Correlation Algorithms in MATLAB
Authors: Thoma Andreas , Moni Abhijith , Ravi Sridhar
Published: March 2021

Digital Image Correlation (DIC) is a powerful tool used to evaluate displacements and deformations in a non-intrusive manner. By comparing two images, one from the undeformed reference states of the sample and the other from the deformed target state, the relative displacement between the two states is determined. DIC is well-known and often used for post-processing analysis of in-plane displacements and deformation of the specimen. Increasing the analysis speed to enable real-time DIC analysis will be beneficial and expand the scope of this method. Here we tested several combinations of the most common DIC methods in combination with different parallelization approaches in MATLAB and evaluated their performance to determine whether the real-time analysis is possible with these methods. The effects of computing with different hardware settings were also analyzed and discussed. We found that implementation problems can reduce the efficiency of a theoretically superior algorithm, such that it becomes practically slower than a sub-optimal algorithm. The Newton–Raphson algorithm in combination with a modified particle swarm algorithm in parallel image computation was found to be most effective. This is contrary to theory, suggesting that the inverse-compositional Gauss–Newton algorithm is superior. As expected, the brute force search algorithm is the least efficient method. We also found that the correct choice of parallelization tasks is critical in attaining improvements in computing speed. A poorly chosen parallelization approach with high parallel overhead leads to inferior performance. Finally, irrespective of the computing mode, the correct choice of combinations of integer-pixel and sub-pixel search algorithms is critical for efficient analysis. The real-time analysis using DIC will be difficult on computers with standard computing capabilities, even if parallelization is implemented, so the suggested solution would be to use graphics processing unit (GPU) acceleration.
Spatial and Temporal Virus Load Dynamics of SARS-CoV-2: A Single-Center Cohort Study
Authors: Alidjinou Enagnon , Poissy Julien , Ouafi Mahdi , Caplan Morgan , Benhalima Ilyes , Goutay Julien , Tinez Claire , Faure Karine , Chopin Marie-Charlotte , Yelnik Cécile , Lambert Marc , Hober Didier , Preau Sébastien ,   The Lille COVID Research Network (LICORNE), Nseir Saad , Engelmann Ilka
Published: March 2021

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused an ongoing pandemic. Reverse transcription polymerase chain reaction (RT-PCR) is the gold standard for the detection of SARS-CoV-2 and has been applied to different specimen types. Understanding the virus load and virus detection frequency in different specimen types is important to improve diagnosis and estimate the duration of potential infectivity. We conducted a retrospective single-center cohort study on hospitalized and outpatients with SARS-CoV-2 infection. We analyzed the frequency of virus detection, virus load, and duration of the virus excretion in upper and lower respiratory specimens as well as stool and plasma. We found that the frequency of SARS-CoV-2 detection, the virus load, and duration of virus excretion was higher in lower respiratory tract (LRT) than in upper respiratory tract (URT) specimens. The duration of virus excretion was longer in patients requiring intensive care unit (ICU) admission. In conclusion, LRT specimens are the most appropriate specimen type for the detection and follow-up of SARS-CoV-2 infection. Duration of virus excretion is longer in severe cases of SARS-CoV-2 infection.
Model Predictive Current Control of Multiphase Motor at Low Carrier Ratio
Authors: Huang Qilan , Kang Min
Published: March 2021

Multiphase motors have multiple control planes, and harmonics are decoupled in different planes. Multiphase motors can improve magnetic field distribution, power density and core utilization by injecting certain harmonic currents into the harmonic planes. In the harmonic plane control process, due to the switching frequency of the inverter being limited, the ratio of the switching frequency to the current frequency (the carrier ratio) of the harmonic plane is low, the digital control delay increases, and the inverter output current contains more harmonics, which makes it difficult for the proportional-integral (PI) current controller to effectively control the d-axis and q-axis currents of the harmonic plane and thus unable to track the given values stably. Moreover, the PI current controller is relatively dependent on the motor parameters. For these reasons, a model predictive current control method with predictive error compensation is proposed. Taking a nine-phase induction motor as an example, the control voltage is calculated by the cost function and corrected by the current predictive error, which realizes the current control method at a low carrier ratio. Additionally, the robustness of the control method is analyzed after the parameters of the multiphase motor have large errors. The experimental results show that the proposed method can control the current of the harmonic plane at low carrier ratio, accurately track the harmonic current commands and attain strong robustness for the motor parameters.
Place Attachment and Concern in Relation to Family Forest Landowner Behavior
Authors: Leahy Jessica , Lyons Patrick
Published: March 2021

Contemporary approaches to studying family forests have identified distinct subgroups of landowners through segmentation analysis. Our study expands on this approach, incorporating the concept of place to provide a novel perspective on how the cognition and emotions that create place attachment and landowner concerns influence certain landowner behaviors. We specifically modeled legacy planning and future landowner ownership behavioral intentions/behaviors. A mail survey was administered to a statewide sample of Maine family forest landowners that measured place attachment and landowner concerns regarding biophysical and social conditions on their woodland. Results based on the 878 respondents (54.9% response rate) indicated place attachment and landowner concern are related to legacy planning, land ownership, and development behavioral intentions, and when considered in conjunction with segmentation analysis, it was found the majority of family forest landowners in the sample experienced strong place attachment and moderate levels of concern. Our study suggests that forest outreach, forest policies and additional family forest research should further consider and incorporate the intangibles of the landowner experience.
Estimating PQoS of Video Conferencing on Wi-Fi Networks Using Machine Learning
Authors: Morshedi Maghsoud , Noll Josef
Published: March 2021

Video conferencing services based on web real-time communication (WebRTC) protocol are growing in popularity among Internet users as multi-platform solutions enabling interactive communication from anywhere, especially during this pandemic era. Meanwhile, Internet service providers (ISPs) have deployed fiber links and customer premises equipment that operate according to recent 802.11ac/ax standards and promise users the ability to establish uninterrupted video conferencing calls with ultra-high-definition video and audio quality. However, the best-effort nature of 802.11 networks and the high variability of wireless medium conditions hinder users experiencing uninterrupted high-quality video conferencing. This paper presents a novel approach to estimate the perceived quality of service (PQoS) of video conferencing using only 802.11-specific network performance parameters collected from Wi-Fi access points (APs) on customer premises. This study produced datasets comprising 802.11-specific network performance parameters collected from off-the-shelf Wi-Fi APs operating at 802.11g/n/ac/ax standards on both 2.4 and 5 GHz frequency bands to train machine learning algorithms. In this way, we achieved classification accuracies of 92–98% in estimating the level of PQoS of video conferencing services on various Wi-Fi networks. To efficiently troubleshoot wireless issues, we further analyzed the machine learning model to correlate features in the model with the root cause of quality degradation. Thus, ISPs can utilize the approach presented in this study to provide predictable and measurable wireless quality by implementing a non-intrusive quality monitoring approach in the form of edge computing that preserves customers’ privacy while reducing the operational costs of monitoring and data analytics.
Political Mobilization in the Laboratory: The Role of Norms and Communication
Authors: Robalo Pedro
Published: March 2021

Many field experiments have shown that political mobilization increases voter turnout, with personalized strategies considerably outperforming widely administered ones. Despite the abundant evidence, there is no systematic explanation of what drives citizens’ response to mobilization. In this paper, I propose and experimentally test in the laboratory a theoretical framework that investigates the psychological mechanisms underlying mobilization in both partisan and non-partisan settings. I conjecture that material mobilization efforts should increase participation because of reciprocity concerns. The transmission of normative appeals through interpersonal communication should have a similar effect by making a group norm salient. The results from two experiments show that the combination of a mobilization effort with a normative appeal leads to a significant and substantial increase in participation in both settings. Using content analysis, I show that this interaction effect is due to the way normative appeals are perceived when the sender is in charge of mobilization.
Microemulsions as Solubilizers and Penetration Enhancers for Minoxidil Release from Gels
Authors: Špaglová Miroslava , Čuchorová Mária , Čierna Martina , Poništ Silvester , Bauerová Katarína
Published: March 2021

Micro- and nanoemulsions are potential drug solubilizers and penetration enhancers through the high surfactant/co-surfactant content. This study aimed to evaluate the influence of minoxidil (MXD) solubilized in the microemulsions (MEs) on drug release by in vitro/ex vivo diffusion through the semi-permeable membrane Spectra/Por® (Spectrum Laboratory, Gardena, CA, USA) and porcine ear skin. Moreover, a residual amount of drug in the skin after ex vivo diffusion was evaluated. The reference MER, lecithin-containing MEL, and gelatin-containing MEG were characterized in terms of their size, polydispersity index, density, viscosity, electrical conductivity and surface tension. Based on the in vitro diffusion, it can be argued that MEL slowed down the drug release, while MER and MEG have no significant effect compared to the sample, in which propylene glycol (PG) was used as a solubilizer. Determination of the residual drug amount in the skin after 6 h of the ex vivo permeation was demonstrated as the most valuable method to evaluate the effectiveness of the ME’s application. The results indicate that the most optimal MXD permeation enhancers in alginate gel were the natural surfactants containing MEs. MXD solubilization in MEG and MEL had caused more than 5% of the drug remaining in the skin, which is almost a 1.5-fold higher amount compared to the reference gel.
Mapping Urban and Peri-Urban Land Cover in Zimbabwe: Challenges and Opportunities
Authors: Kamusoko Courage , Kamusoko Olivia Wadzanai , Chikati Enos , Gamba Jonah
Published: March 2021

Accurate and current land cover information is required to develop strategies for sustainable development and to improve the quality of life in urban areas. This study presents an approach that combines multi-seasonal Sentinel-1 (S1) and Sentinel-2 (S2) data, and a random forest (RF) classifier in order to map land cover in four major urban centers in Zimbabwe. The specific objective of this study was to assess the potential of multi-seasonal (rainy, post-rainy, and dry season) S1, rainy season S2, post-rainy season, dry season S2, multi-seasonal S2, and multi-seasonal composite S1 and S2 data for mapping land cover in urban areas. The study results show that the combination of multi-seasonal S1 and S2 data improve land cover mapping in urban and peri-urban areas relative to only multi-seasonal S1, mono-seasonal S2, and multi-seasonal S2 data. The overall accuracy scores for the multi-seasonal S1 and S2 land cover maps are above 85% for all urban centers. Our results indicate that rainy and post-rainy S2 spectral bands, as well as dry-season S1 VV and VH bands (ascending orbit) are the most important features for land cover mapping. In particular, S1 data proved useful in separating built-up areas from cropland, which is usually problematic when only optical imagery is used in the study area. While there are notable improvements in land cover mapping, some challenges related to the S1 data analysis still remain. Nonetheless, our land cover mapping approach shows a potential to map land cover in other urban areas in Zimbabwe or in Sub-Sahara Africa. This is important given the urgent need for reliable geospatial information, which is required to implement the United Nations Sustainable Development Goals (UN SDGs) and United Nations New Urban Agenda (NUA) programmes.
Prevalence of Low Back Pain among Primary School Students from the City of Valencia (Spain)
Authors: Miñana-Signes Vicente , Monfort-Pañego Manuel , Bosh-Bivià Antonio Hans , Noll Matias
Published: March 2021

It is well-known that low back pain (LBP) prevalence is high among school-age children. However, literature concerning the initial onset of back pain between the ages of three and eleven years is scarce. The present study aims to analyze the prevalence of LBP in kindergarten and primary school students. A total of 278 (9.9 ± 2.1 years old; 52.2% girls) students from two public kindergartens and primary schools in Valencia (Spain) participated in this cross-sectional study. The Nordic questionnaire on LBP was used to assess the onset and duration of LBP symptoms. The lifetime prevalence of LBP was 47.5% (n = 132), the last year’s prevalence was 44.2% (n = 123), and last week’s prevalence was 18.8% (n = 50). Boys and girls reported a lifetime prevalence of 52.3% (n = 64) and 47.7% (n = 63) (p = 0.186, Fisher’s exact test, 2-sided), respectively. By age group, lifetime episodes of LBP became more prevalent with increasing age (p < 0.001, Fisher’s exact test, 2-sided). In summary, our findings show that LBP increases with age and further strengthens the evidence that LBP onset could start as young as 10 years of age.
Linking Female Adolescents’ Knowledge, Attitudes and Use of Contraceptives to Adolescent Pregnancy in Ghana: A Baseline Data for Developing Sexuality Education Programmes
Authors: Ahinkorah Bright Opoku , Hagan John Elvis , Seidu Abdul-Aziz , Hormenu Thomas , Otoo John Ekow , Budu Eugene , Schack Thomas
Published: March 2021

(1) Background: Nearly one out of ten Ghanaian female adolescents aged 15–19 has experienced childbearing in urban settlements compared to twice this number in the rural populations due to unintended pregnancies. This study assessed the linkages between knowledge, attitudes, and use of contraceptives and adolescent pregnancy in one of the highly affected Municipalities (i.e., Komenda-Edina-Eguafo Abrem [KEEA]) in Ghana. (2) Methods: Employing a facility-based sampling method, 378 female adolescents aged 15–19 were selected. Unadjusted odds ratio (uOR) and adjusted odds ratio (aOR) at 95% confidence intervals (CI) and p-values were used for significant variables at p < 0.05. (3) Results: Pregnant adolescents were 2 times more likely to indicate that the procedure of procuring contraceptives is quite uncomfortable (aOR = 2.42, 95% CI = [1.29–4.55]; p = 0.006). Also, pregnant adolescents were 5 times more likely to have ever used traditional contraceptive methods than their non-pregnant counterparts (aOR = 5.02, 95% CI = [2.60–9.71]; p < 0.001). On the contrary, pregnant adolescents had lower odds of indicating that contraceptives are for only married people (aOR = 0.38, 95% CI = [0.20–0.70]; p = 0.002) and that it feels bad to receive contraceptive information from parents and relatives than non-pregnant adolescents (aOR = 0.42, 95% CI = [0.24–0.74]; p = 0.003). Pregnant adolescents were less likely to use modern contraceptives than their non-pregnant adolescents (aOR = 0.18, 95% CI = [0.11–0.31]; p < 0.001). (4) Conclusions: The findings indicate that female adolescents’ use of traditional contraceptives is associated with the risk of pregnancy in KEEA Municipality within the Central Region of Ghana. However, adolescents who had the perception that contraceptives are for married people and those who used modern contraceptives were less likely to get pregnant. Government and non-governmental organizations in Ghana should implement educational policies and programmes aimed at educating sexually-active female adolescents on modern contraceptives and the need to use them to prevent pregnancies. The basis for such policies and programmes should be based on evidence that compared to traditional contraceptives, modern contraceptives are more effective. In addition, there is the need to provide accurate information regarding the use of contraceptives to adolescents that will help change their attitudes towards the use of contraceptives.
Editorial for the Special Issue on “Experiencing the City: The Relation between Urban Design and People’s Well-Being”
Authors: Weijs-Perrée Minou , Dane Gamze , van den Berg Pauline
Published: March 2021

Urbanization brings major challenges with regard to livability and the health and quality of life of citizens [...]
Impact of Regional Green Development Strategy on Environmental Total Factor Productivity: Evidence from the Yangtze River Economic Belt, China
Authors: Guo Kailu , Li Shixiang , Wang Zhanqi , Shi Jianru , Bai Jun , Cheng Jinhua
Published: March 2021

Chinese government policy officially identify the Yangtze River Economic Belt (YREB) as one of regional green development strategies firstly in 2014. This strategy can be regarded as quasi-natural experiment, this paper aims to test its impact on regional environmental total factor productivity (TFP). First, slack-based measure model is used to calculate the environmental TFP from 2005 to 2017 at provincial level. Second, based on Chinese official statistics, differences-in-differences (DID) method is applied to construct an evaluation model of policy effect, combining with the kernel matching in propensity score matching (PSM) method. The results show that environmental TFP of YREB has significant spatial differences, with characteristic of high-east and low-west, its average level is 11.69 percentage points higher than the national average. YREB strategy promotes regional economic growth, but it does no effect on the regional environmental TFP yet. Modelling suggests that YREB strategy may play a role in the short term. From the significance of the control variables, infrastructure construction level is positively correlated with environmental TFP, while per capita GDP, financial development and energy consumption intensity have negative effect on environmental TFP. Based on this, policymakers should focus on green development, promoting industrial transformation, and enhancing environmental protection.
Outdoor Activity Participation Improves Adolescents’ Mental Health and Well-Being during the COVID-19 Pandemic
Authors: Jackson S. Brent , Stevenson Kathryn T. , Larson Lincoln R. , Peterson M. Nils , Seekamp Erin
Published: March 2021

COVID-19 is reshaping human interactions with the natural environment, potentially generating profound consequences for health and well-being. To assess the effects of COVID-19 on the outdoor recreation participation and subjective well-being of adolescents, as well as how participation in outdoor activities may mitigate declines in subjective well-being, we used a Qualtrics XM panel to conduct a nationally representative survey of youth ages 10–18 across the United States (n = 624) between 30 April and 15 June 2020. Survey questions focused on frequency of participation in outdoor activities before and during the pandemic, as well as changes in subjective well-being. Paired t-tests revealed decreases in both outdoor recreation participation (64% reported declines) and subjective well-being (52% reported declines). A regression model examining correlates of changes in subjective well-being (R2 = 0.42) revealed strong associations with changes in outdoor play (B = 0.44, p < 0.001) and nature-based (B = 0.21, p = 0.016) activities. Adolescents’ from all backgrounds who participated in these activities during the pandemic reported smaller declines in subjective well-being. Results highlight the critical role that time outdoors and time in nature play in bolstering adolescents’ resilience to stressors such as the COVID-19 pandemic and underscore the need to facilitate outdoor recreation opportunities for youth during times of crisis.
Increased Cardiopulmonary Fitness Is Associated with a Greater Reduction in Depression among People Who Underwent Bariatric Surgery
Authors: Vetrovsky Tomas , Fortova Tereza , Conesa-Ros Elena , Steffl Michal , Heczkova Jana , Belohlavek Jan , Courel-Ibáñez Javier
Published: March 2021

The aim of this study was to determine the effect of changes in cardiopulmonary fitness on the mental health of patients with severe obesity who underwent gastric bypass surgery (prior to and 1, 3, and 6 months after surgery). Study participants were recruited from among patients of a regional hospital in Czechia who underwent gastric bypass surgery between April 2018 and October 2019. They were eligible if they (a) were between 18 and 65 years old, (b) provided written informed consent, and (c) were able to walk independently. Twenty-six patients (age 45.4 ± 9.0 years, body mass index 45.1 ± 7.4 kg·m−2, body fat 43.8 ± 4.8%) were included in the analysis. The key finding revealed that the greater the increase in cardiopulmonary fitness (i.e., longer distance walked in the six-minute walk test, 6MWT), the better the improvement in depression score among patients who underwent bariatric surgery. In particular, increments of 10 m in the 6MWT lead to the improvement of 0.5 points on the depression subscale of the Hospital Anxiety and Depression Scale (HADS) questionnaire. As the main implication, these results suggest that patients should participate in exercise training programs to increase their fitness status for optimal physical and mental outcomes of bariatric surgery.
Sustainable Development of Transport as a Regional Policy Target for Sustainable Development—A Case Study of Poland
Authors: Ogryzek Marek , Wolny-Kucińska Ada
Published: March 2021

In central and eastern European countries that joined the European Union (EU) in 2004 and 2007, there are strong connections between transport development and sustainable regional development. The needs for transport development in post-socialist countries are so high that it is difficult to finance them, and most governments have to choose between immediate and less urgent needs. The aim of this study was to determine the role played by sustainable transport growth in the improvement of regional cohesion and sustainable regional development with a use of geographical information systems’ capabilities. The specific goals of the study were to: (i) determine the impact of EU subsidies on the regional transport development; (ii) identify threats to regional cohesion resulting from under-capitalised regions, (iii) examine geographical information systems’ capabilities in periodical regional transport development monitoring. The analyses include evaluation of the regions’ involvement in sustainable transport development as well as the presentation of direct and indirect results, such as road system improvement, with the use of GIS capabilities. It is particularly important to develop a system for monitoring the level of EU fund allocation with the use of GIS tools and the capabilities of geographic information systems. Such in-depth analysis would be useful for regional governments and decision-makers in creating and updating long term transport policies as well as monitoring long term regional development strategies. Both sustainable transport development and EU fund allocation can be monitored within the use of GIS tools, and such analyses should supplement the INSPIRE Geoportal scope.
PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway
Authors: Li Yanqing , Kang Jinsong , Fu Jiaying , Luo Haoge , Liu Yanan , Li Yang , Sun Liankun
Published: March 2021

Mitochondrial apoptosis is one of the main mechanisms for cancer cells to overcome chemoresistance. Hexokinase 2 (HK2) can resist cancer cell apoptosis by expressing on mitochondria and binding to voltage-dependent anion channel 1 (VDAC1). We previously reported that peroxisome proliferator-activated receptor coactivator 1 α (PGC1α) is highly expressed in ovarian cancer cisplatin-resistant cells. However, the underlying mechanism remains unclear. Therefore, we evaluated the interaction between PGC1α and HK2 in ovarian cancer cisplatin-resistant cells. We found that the knockdown of PGC1α promotes the apoptosis of ovarian cancer cisplatin-resistant cells and increases their sensitivity to cisplatin. In addition, we found that the knockdown of PGC1α affects the mitochondrial membrane potential and the binding of HK2 and VDAC1. As the heat shock protein 70 (HSP70) family can help protein transport, we detected it and found that PGC1α can promote HSP70 gene transcription. Furthermore, HSP70 can promote an increase of HK2 expression on mitochondria and an increase of binding to VDAC1. Based on these results, PGC1α may reduce apoptosis through the HSP70/HK2/VDAC1 signaling pathway, thus promoting cisplatin resistance of ovarian cancer. These findings provide strong theoretical support for PGC1α as a potential therapeutic target of cisplatin resistance in ovarian cancer.
Exploring Two Honey Bee Traits for Improving Resistance Against Varroa destructor: Development and Genetic Evaluation
Authors: Guichard Matthieu , Droz Benoît , Brascamp Evert W. , von Virag Adrien , Neuditschko Markus , Dainat Benjamin
Published: March 2021

For the development of novel selection traits in honey bees, applicability under field conditions is crucial. We thus evaluated two novel traits intended to provide resistance against the ectoparasitic mite Varroa destructor and to allow for their straightforward implementation in honey bee selection. These traits are new field estimates of already-described colony traits: brood recapping rate (‘Recapping’) and solidness (‘Solidness’). ‘Recapping’ refers to a specific worker characteristic wherein they reseal a capped and partly opened cell containing a pupa, whilst ‘Solidness’ assesses the percentage of capped brood in a predefined area. According to the literature and beekeepers’ experiences, a higher recapping rate and higher solidness could be related to resistance to V. destructor. During a four-year field trial in Switzerland, the two resistance traits were assessed in a total of 121 colonies of Apis mellifera mellifera. We estimated the repeatability and the heritability of the two traits and determined their phenotypic correlations with commonly applied selection traits, including other putative resistance traits. Both traits showed low repeatability between different measurements within each year. ‘Recapping’ had a low heritability (h2 = 0.04 to 0.05, depending on the selected model) and a negative phenotypic correlation to non-removal of pin-killed brood (r = −0.23). The heritability of ‘Solidness’ was moderate (h2 = 0.24 to 0.25) and did not significantly correlate with resistance traits. The two traits did not show an association with V. destructor infestation levels. Further research is needed to confirm the results, as only a small number of colonies was evaluated.
Hemodialysis as a Risk Factor for Lower Right Internal Jugular Stenosis in Cardiac Surgery Patients: A Retrospective Single-Center Study
Authors: Ju Jae-Woo , Oh Yoomin , Yang Hyo Jun , Lee Seohee , Bae Jinyoung , Nam Karam , Cho Youn Joung , Jeon Yunseok , Kim Tae Kyong
Published: March 2021

Lower right internal jugular vein (RIJ) stenosis has been reported as a common cause of RIJ catheterization failure. However, the risk factors for lower RIJ stenosis in patients undergoing cardiac surgery is unclear. We reviewed the electronic medical records of all adult patients who had undergone cardiac operations in a single tertiary university hospital from January 2014 to January 2016. Patients were excluded if they were lack of preoperative contrast-enhanced chest computed tomography (CT) studies. Lower RIJ stenosis was defined as a ratio of cross-sectional area at the smallest level to cross-sectional area at the largest level less than 25%. Multivariable logistic regression analyses were used to investigate the risk factors for lower RIJ stenosis. A sensitivity analysis was also conducted using a cross-sectional area ratio of under 20%. The analysis included 889 patients, and the incidence of lower RIJ stenosis was 3.9%. The multivariable logistic regression analyses revealed that hemodialysis was an independent risk factor for lower RIJ stenosis (OR, 3.54; 95% CI, 1.472–8.514). Sensitivity analysis provided that hemodialysis (OR, 10.842; 95% CI, 3.589–32.75) was a significant predictor of cross-sectional area ratio <20%. Preoperative hemodialysis are significantly associated with an increased risk of lower RIJ stenosis in patients undergoing cardiac surgery. Extra care is needed during central venous catheterization in hemodialysis patients undergoing cardiac surgery.
A Time-Based Meta-Analysis on the Incidence of New Onset Diabetes after Liver Transplantation
Authors: Chin Yip Han , Tan Hon Qin Marcus , Ng Cheng Han , Tan Darren Jun Hao , Lin Snow Yunni , Huang Daniel Q. , Khoo Chin Meng , Muthiah Mark Dhinesh
Published: March 2021

NODAT (new-onset diabetes after transplantation) is an important complication after liver transplant, however, there is variation in the reported incidence of NODAT. Therefore, a meta-analysis was performed to estimate the incidence of NODAT in liver transplant. Electronic databases were searched for articles regarding NODAT incidence after liver transplantation. Incidence of NODAT were analyzed at six different timepoints. Summary statistics were calculated using a generalized linear mixed model in random effects. 28 articles were included and out of a pooled population of 71,257 patients, overall incidence of NODAT was found to be 15.51%, 16.09%, 18.30%, 20.86%, 18.08%, 25.05% for three-months, six-months, one-year, three-year, five-year, and ten-year timepoints respectively. After a sensitivity analysis which only included articles with clear definitions of NODAT, the incidence of NODAT was found to be higher at three-year (21.79%), five-year (25.82%), and ten-year (44.95%) timepoints. Subgroup analysis according to ethnicity found no significant differences for all timepoints. However, studies with predominantly Asian participants generally had a higher incidence of NODAT. In conclusion, this meta-analysis provides a pooled estimate of the incidence of NODAT following liver transplantation. Further studies are required to provide a more comprehensive understanding on how ethnicity can affect the incidence of NODAT.
Covariate Model of Pixel Vector Intensities of Invasive H. sosnowskyi Plants
Authors: Daugela Ignas , Suziedelyte Visockiene Jurate , Tumeliene Egle , Skeivalas Jonas , Kalinka Maris
Published: March 2021

This article describes an agricultural application of remote sensing methods. The idea is to aid in eradicating an invasive plant called Sosnowskyi borscht (H. sosnowskyi). These plants contain strong allergens and can induce burning skin pain, and may displace native plant species by overshadowing them, meaning that even solitary individuals must be controlled or destroyed in order to prevent damage to unused rural land and other neighbouring land of various types (mostly violated forest or housing areas). We describe several methods for detecting H. sosnowskyi plants from Sentinel-2A images, and verify our results. The workflow is based on recently improved technologies, which are used to pinpoint exact locations (small areas) of plants, allowing them to be found more efficiently than by visual inspection on foot or by car. The results are in the form of images that can be classified by several methods, and estimates of the cross-covariance or single-vector auto-covariance functions of the contaminant parameters are calculated from random functions composed of plant pixel vector data arrays. The correlation of the pixel vectors for H. sosnowskyi images depends on the density of the chlorophyll content in the plants. Estimates of the covariance functions were computed by varying the quantisation interval on a certain time scale and using a computer programme based on MATLAB. The correlation between the pixels of the H. sosnowskyi plants and other plants was found, possibly because their structures have sufficiently unique spectral signatures (pixel values) in raster images. H. sosnowskyi can be identified and confirmed using a combination of two classification methods (using supervised and unsupervised approaches). The reliability of this combined method was verified by applying the theory of covariance function, and the results showed that H. sosnowskyi plants had a higher correlation coefficient. This can be used to improve the results in order to get rid of plants in particular areas. Further experiments will be carried out to confirm these results based on in situ fieldwork, and to calculate the efficiency of our method.
Impacts of Consolidation Time on the Critical Hydraulic Gradient of Newly Deposited Silty Seabed in the Yellow River Delta
Authors: Tang Meiyun , Jia Yonggang , Zhang Shaotong , Wang Chenxi , Liu Hanlu
Published: March 2021

The silty seabed in the Yellow River Delta (YRD) is exposed to deposition, liquefaction, and reconsolidation repeatedly, during which seepage flows are crucial to the seabed strength. In extreme cases, seepage flows could cause seepage failure (SF) in the seabed, endangering the offshore structures. A critical condition exists for the occurrence of SF, i.e., the critical hydraulic gradient (icr). Compared with cohesionless sands, the icr of cohesive sediments is more complex, and no universal evaluation theory is available yet. The present work first improved a self-designed annular flume to avoid SF along the sidewall, then simulated the SF process of the seabed with different consolidation times in order to explore the icr of newly deposited silty seabed in the YRD. It is found that the theoretical formula for icr of cohesionless soil grossly underestimated the icr of cohesive soil. The icr range of silty seabed in the YRD was 8–16, which was significantly affected by the cohesion and was inversely proportional to the seabed fluidization degree. SF could “pump” the sediments vertically from the interior of the seabed with a contribution to sediment resuspension of up to 93.2–96.8%. The higher the consolidation degree, the smaller the contribution will be.
Exploring a Flooding-Sensors-Agnostic Prediction of the Damage Consequences Based on Machine Learning
Authors: Braidotti Luca , Valčić Marko , Prpić-Oršić Jasna
Published: March 2021

Recently, progressive flooding simulations have been applied onboard to support decisions during emergencies based on the outcomes of flooding sensors. However, only a small part of the existing fleet of passenger ships is equipped with flooding sensors. In order to ease the installation of emergency decision support systems on older vessels, a flooding-sensor-agnostic solution is advisable to reduce retrofit cost. In this work, the machine learning algorithms trained with databases of progressive flooding simulations are employed to assess the main consequences of a damage scenario (final fate, flooded compartments, time-to-flood). Among the others, several classification techniques are here tested using as predictors only the time evolution of the ship floating position (heel, trim and sinkage). The proposed method has been applied to a box-shaped barge showing promising results. The promising results obtained applying the bagged decision trees and weighted k-nearest neighbours suggests that this new approach can be the base for a new generation of onboard decision support systems.
The Influence of Reef Topography on Storm-Driven Sand Flux
Authors: Bosserelle Cyprien , Gallop Shari L. , Haigh Ivan D. , Pattiaratchi Charitha B.
Published: March 2021

Natural formations of rock and coral can support geologically controlled beaches, where the beach dynamics are significantly influenced by these structures. However, little is known about how alongshore variations in geological controls influence beach morphodynamics. Therefore, in this study we focus on the storm response of a beach (Yanchep in south Western Australia) that has strong alongshore variation in the level of geological control because of the heterogeneous calcarenite limestone reef. We used a modified version of XBeach to simulate the beach morphodynamics during a significant winter storm event. We find that the longshore variation in topography of the reef resulted in: (1) strong spatial difference in current distribution, including areas with strong currents jets; and (2) significant alongshore differences in sand flux, with larger fluxes in areas strongly geologically controlled by reefs. In particular, this resulted in enhanced beach erosion at the boundary of the reef where strong currents jet-exited the nearshore.
Birds and Bioenergy within the Americas: A Cross-National, Social–Ecological Study of Ecosystem Service Tradeoffs
Authors: Knowlton Jessie , Halvorsen Kathleen , Flaspohler David , Webster Christopher , Abrams Jesse , Almeida Sara , Arriaga-Weiss Stefan , Barnett Brad , Cardoso Maíra , Cerqueira Pablo , Córdoba Diana , Dantas-Santos Marcos , Dunn Jennifer , Eastmond Amarella , Jarvi Gina , Licata Julian , Mata-Zayas Ena , Medeiros Rodrigo , Mesa-Jurado M. , Moo-Culebro Lízbeth , Moseley Cassandra , Nielsen Erik , Phifer Colin , Pischke Erin , Schelly Chelsea , Selfa Theresa , Silva Chelsea , Souza Tatiana , Sweitz Samuel , Vázquez-Navarrete César
Published: March 2021

Although renewable energy holds great promise in mitigating climate change, there are socioeconomic and ecological tradeoffs related to each form of renewable energy. Forest-related bioenergy is especially controversial, because tree plantations often replace land that could be used to grow food crops and can have negative impacts on biodiversity. In this study, we examined public perceptions and ecosystem service tradeoffs between the provisioning services associated with cover types associated with bioenergy crop (feedstock) production and forest habitat-related supporting services for birds, which themselves provide cultural and regulating services. We combined a social survey-based assessment of local values and perceptions with measures of bioenergy feedstock production impacts on bird habitat in four countries: Argentina, Brazil, Mexico, and the USA. Respondents in all countries rated birds as important or very important (83–99% of respondents) and showed lower enthusiasm for, but still supported, the expansion of bioenergy feedstocks (48–60% of respondents). Bioenergy feedstock cover types in Brazil and Argentina had the greatest negative impact on birds but had a positive impact on birds in the USA. In Brazil and Mexico, public perceptions aligned fairly well with the realities of the impacts of potential bioenergy feedstocks on bird communities. However, in Argentina and the USA, perceptions of bioenergy impacts on birds did not match well with the data. Understanding people’s values and perceptions can help inform better policy and management decisions regarding land use changes.
Leaving No Stone Unturned: Flexible Retrieval of Idiomatic Expressions from a Large Text Corpus
Authors: Hughes Callum , Filimonov Maxim , Wray Alison , Spasić Irena
Published: March 2021

Idioms are multi-word expressions whose meaning cannot always be deduced from the literal meaning of constituent words. A key feature of idioms that is central to this paper is their peculiar mixture of fixedness and variability, which poses challenges for their retrieval from large corpora using traditional search approaches. These challenges hinder insights into idiom usage, affecting users who are conducting linguistic research as well as those involved in language education. To facilitate access to idiom examples taken from real-world contexts, we introduce an information retrieval system designed specifically for idioms. Given a search query that represents an idiom, typically in its canonical form, the system expands it automatically to account for the most common types of idiom variation including inflection, open slots, adjectival or adverbial modification and passivisation. As a by-product of query expansion, other types of idiom variation captured include derivation, compounding, negation, distribution across multiple clauses as well as other unforeseen types of variation. The system was implemented on top of Elasticsearch, an open-source, distributed, scalable, real-time search engine. Flexible retrieval of idioms is supported by a combination of linguistic pre-processing of the search queries, their translation into a set of query clauses written in a query language called Query DSL, and analysis, an indexing process that involves tokenisation and normalisation. Our system outperformed the phrase search in terms of recall and outperformed the keyword search in terms of precision. Out of the three, our approach was found to provide the best balance between precision and recall. By providing a fast and easy way of finding idioms in large corpora, our approach can facilitate further developments in fields such as linguistics, language education and natural language processing.
Stretch Forming Behavior and Constitutive Equation of a Modified 5083 Alloy with High Mg Content at Elevated Temperatures
Authors: Yang Seung-Yoon , Lee Da-Bin , Choi Kweon-Hoon , Kim Nam-Seok , Ha Seong-Ho , Kim Bong-Hwan , Yoon Young-Ok , Lim Hyun-Kyu , Kim Shae K. , Kim Young-Jig
Published: March 2021

For the purpose of applying a modified 5083 alloy (New 5083M alloy) with high Mg content in various automotive sheet parts, the stretch forming behavior of the 5083M alloy was studied in tensile mode at a wide range of processing conditions. The tensile tests were conducted by using a tensile test machine under the temperature ranges of 100–400 °C and the strain rate ranges of 0.001–1 s−1. The test results showed that the 5083M alloy has superior mechanical properties to that of the commercial 5083 alloy at elevated temperatures. The microstructure before and after the stretch forming was analyzed using optical microscope (OM) equipped with a polarizing filter and electron backscattered diffraction (EBSD) unit. Deformed microstructure was observed under low temperature conditions and dynamic recrystallized microstructure under high temperature conditions. However, regardless of microstructure evolution, developed deformation textures were distributed in orientation distribution functions (ODF) images. In addition, at high temperature and low strain rate condition, complex shaped cavities which were detrimental to mechanical properties appeared at the grain boundary and grain triple junction. Based on the test results data, a constitutive equation predicting the deformation behavior of the 5083M alloy was derived. The calculated curves by the constitutive equation were compared with the measured curves by experiment and agreed well.