bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a MRI radiomic-based ML model to predict aggressiveness of prostate cancer
Authors: Dominguez Ignacio , Caprile Paola , Rios Odette , San-Francisco Ignacio , Besa Cecilia
Published: August 2023

We developed a non-invasive tool to predict the GS classification of PCa based on mpMRI information using ML. This retrospective study included 86 male patients with positive PCa fusion (mpMRI-ultrasound) biopsy. A radiomic analysis was performed considering first order, textural, shape, and clinical information. The best model found included image (T2w - ADC) and clinical information. The mean AUC was 0.91 [0.75−0.99] (p <0.05), with a validation AUC of 0.91 for a classification of high-lower aggressiveness (GS≥7 vs GS=6). Combining MRI-based radiomic and clinical information can significantly improve the model performance to classify PCa aggressiveness.
Integrated DWI for Pre-treatment Prediction of Response to Neoadjuvant Chemotherapy in Breast Cancer
Authors: Karaman Muge , Che Shunan , Dan Guangyu , Zhong Zheng , Ouyang Han , Zhou Xiaohong , Zhao Xinming
Published: August 2023

Neoadjuvant chemotherapy (NAC) has been shown to improve the outcome in patients with locally advanced inoperable or operable breast cancer. An early imaging assessment of response to NAC is critical for managing breast cancer to minimize the toxic side effects of ineffective chemotherapy. In this study, we have used an integrated diffusion-weighted imaging approach for simultaneous assessment of tissue cellularity, vascularity, and heterogeneity – DISMANTLE – from a full b-value spectrum to predict breast cancer’s response to NAC. Histogram features of pre-treatment DISMANTLE parameters were evaluated for predicting tumor response to NAC in terms of pathological complete response.
Assessment of SAR variability across early gestational age subjects at 3T fetal MRI
Authors: Turk Esra Abaci , Yetisir Filiz , Zhou Cindy , Stout Jeffrey , Estroff Judy , Barnewolt Carol , Adalsteinsson Elfar , Grant P. Ellen , Wald Lawrence
Published: August 2023

Despite the clinical and research potential of fetal MRI, there is no consensus on MRI safety in the 1st and early 2nd trimesters. Prior simulation studies at early gestational ages (GA) used only a single or unrealistic pregnant body models. To address this gap, we built 2 realistic uterine models for the early 2nd trimester and placed them into 3 existing pregnant body models at a later GA to investigate differences in RF exposure. Lower pSAR10g in both the fetus and amniotic fluid was observed in the early 2nd trimester models compared to later GA models.
Quantifying Infant Lean Body Mass using Free-Breathing 3D Stack-of-Radial MRI
Authors: Parish Hannah , Shih Shu-Fu , Ghahremani Shahnaz , Kafali Sevgi , Calkins Kara , Wu Holden
Published: August 2023

Lean body mass (LBM) is an important measure of metabolic ability. Decreased LBM during infancy may be associated with impaired growth and increased risk for future metabolic disease. This study measured skeletal muscle area as a surrogate for LBM in infants using free-breathing MRI. Psoas and paraspinal muscle areas were measured in 14 infants at the L4-L5 intervertebral disc level. Cross-sectional area of the thigh muscles was measured at the right midthigh in 8 infants. Infants with higher birth weights and those born large for gestational age had larger muscle areas than infants born lighter and/or small for gestational age.
Combined structural and functional connectivity changes in Fabry disease
Authors: Gabusi Ilaria , Pontillo Giuseppe , Schiavi Simona , Bosticardo Sara , Petracca Maria , Battocchio Matteo , Pisani Antonio , Brunetti Arturo , Daducci Alessandro , Cocozza Sirio
Published: August 2023

Central nervous system involvement in Fabry disease (FD) patients is known, but the effects on brain connectivity have never been explored at macro-scale level. Here, we investigate both structural (SC) and functional connectivity (FC) by analyzing diffusion and resting-state functional MRI. We applied a graph theory approach to compare connectomes of patients and controls and we explored how altered global network metrics are related to patients’ outcome in neuropsychological tests. Our results show that FD patients present a loss of axonal integrity which leads to a widespread reorganization of brain structural and functional architecture, related to their clinical performances.
Mapping Brain Development in Infants and Young Children Using MPnRAGE T1 Relaxometry
Authors: Dean Douglas , Shah Leela , DiPiero Marissa , Pletcher Colleen , Heinrich Lauren , Planalp Elizabeth , Alexander Andrew , Kecskemeti Steven
Published: August 2023

Quantitative magnetic resonance imaging during the first years of life can provide novel insights into brain maturation, yet acquisition of these data are limited by challenges in imaging pediatric populations. Here, we assessed the self-navigated, motion robust MPnRAGE technique to acquire high-resolution T1-weighted structural brain images and quantitative T1 relaxometry maps in infants and young children. Our results demonstrate the ability to utilize MPnRAGE as a robust quantitative technique to assess early brain development.
Regional Brain Volumes, Cortical Thickness, Folding and Sulcal Depth in Perinatally HIV-Infected Youths
Authors: Joy Ajin , Sarma Manoj , Paul Jhelum , Saucedo Andres , Macey Paul , Meyerhoff Dieter , Haroon Ebrahim , Keller Margaret , Thomas M
Published: August 2023

The human immunodeficiency virus (HIV) can affect the morphometry of the developing brain of perinatally HIV (PHIV)-infected youths. Surface-based morphometric analysis can reveal if local effects on gray and white matter volumes is significant in the regions with alterations in cortical thickness (CT), gyrification index (GI), or sulcal depth (SD). So, we compared these morphometric parameters of 19 PHIV-youths on combination antiretroviral therapy with those in 26 uninfected healthy controls. PHIV-youths had altered gray and white matter regional volume, CT, GI, and SD, partly in overlapping regions. The findings survived multiple comparisons using both false discovery rate and Holm-Bonferroni corrections.
Non-Gaussian Brain Diffusion Cross-sectional and Longitudinal Changes in Type 2 Diabetes Mellitus Adults
Authors: Roy Bhaswati , Mercado Daisy , Freeby Matthew , Choi Sarah , Kumar Rajesh
Published: August 2023

Patients with Type 2 diabetes mellitus (T2DM) show brain changes in mood and cognitive control sites, functions that are deficient in the condition, examined by Gaussian diffusion-based diffusion tensor imaging (DTI). However, the majority of brain areas with complex fibers, follow non-Gaussian diffusion, and DTI-based measures may not show adequate diffusion changes. We examined brain changes at baseline and 6 months in T2DM patients using the diffusion kurtosis imaging-based mean kurtosis procedures and showed wide-spread acute and chronic tissue changes in the condition, with continued progression after 6 months in areas involved in mood and cognitive regulatory functions.
MR Elastography: Clinical Protocol Optimization for Liver Stiffness Estimation
Authors: Nanjappa Manjunathan , Raterman Brian , Bolster Bradley D. , Stephan Kannengiesser , Jin Ning , Kolipaka Arunark
Published: August 2023

Magnetic resonance elastography (MRE) has become a standard clinical tool to stage liver fibrosis and it is important to optimize the imaging protocols to achieve robust stiffness measurement. Imaging was performed using a 3T MRI scanner on 20 healthy adult volunteers with varied driver powers and acquisition parameters. The stiffness value at 60Hz across the settings was found to be stable for all the subjects. 40-50% driver power with 20-35mT motion encoding gradient amplitude would deliver adequate shear waves to achieve diagnostic quality of liver stiffness maps.
Practical Approaches to the Evaluation of Signal-to-Noise Ratio Performance with Deep Learning Denoising Image Reconstruction
Authors: Wang Zihan , Weaver Jayse , Tamada Daiki , Hernando Diego , Reeder Scott
Published: August 2023

In this work, three methods for measuring signal-to-noise ratio (SNR) performance of deep learning (DL) denoising image reconstruction were evaluated. Images reconstructed using a vendor prototype DL reconstruction algorithm were compared to conventional Fourier reconstruction. Phantom experiments were performed using a single-channel head coil and a 32-channel head coil to assess the effects of parallel imaging acceleration in combination with DL reconstruction on SNR performance. We found excellent agreement between the three SNR measurement methods for both Fourier and DL reconstruction, and found that DL reconstructed images have similar g-factor performance patterns as Fourier reconstructed images.
Deep Learning for under-sampled non-cartesian ASL MRI reconstruction
Authors: Guo Yanchen , Chen Shichun , Zhao Li , Taso Manuel , Alsop David , Dai Weiying
Published: August 2023

Compressed sensing allowed speeding up MRI image acquisition by several folds but with increased reconstruction time. Deep-learning was introduced for fast reconstruction with comparable or improved reconstruction quality. However, its applications on non-cartesian grids are scarce, mostly based on simulated resampling from original Cartesian grids. Here, we evaluated the performance of two deep-learning networks for reconstructing images acquired with k-space spiral trajectories in real MRI scanning. We demonstrated that deep learning networks can successfully reconstruct high-resolution images from under-sampled spiral trajectories with half of data in k-space and their performance is robust to spiral trajectories different from training.
Accelerated Radial Echo Planar Spectroscopic Imaging in Healthy Prostate with a Reduced Field-of-View
Authors: Saucedo Andres , Thomas M. Albert
Published: August 2023

Radial echo planar spectroscopic imaging (REPSI) is applied in healthy prostate and compared to Cartesian EPSI acquisitions. Due to the small spatial extent of the anatomy-of-interest, REPSI is well-suited for acceleration in a reduced-field-of-view context. In this proof-of-concept study, we acquired both prospectively and retrospectively undersampled REPSI and Cartesian EPSI datasets in prostate phantom and in vivo, at multiple acceleration factors, and we compared both quantitative and qualitative results.
Selective Refocusing Pulse Design via Time-varying Nonlinear Shim Array Fields and RF Pulse with Decomposition Property
Authors: Zhang Molin , Arango Nicolas , Stockmann Jason , White Jacob , Adalsteinsson Elfar
Published: August 2023

Shim arrays provide nonlinear, time-varying fields that can extend the possibility of linear gradient field for RF excitations. In this work, we explore the possibility of designing a selective refocusing 180° pulse for a restricted slice pattern of 1.2cm thickness, aimed at application for the fetal brain. We use an auto-differentiable Bloch simulator framework for the design, but without the presentence of crusher gradients. Decomposition property is employed to overcome the undetermined initial magnetization. The selective refocusing profile achieves selective refocusing for 85% of voxels in the ROI (My< -0.9).
Improved Phase-cycling Preparations in Quantitative T1rho Mapping
Authors: Peng Gregory , Wu Can , Peng Qi
Published: August 2023

Phase-cycling (PC) has been proposed as an effective method to minimize the impact of B0 and B1 field inhomogeneities in quantitative T1rho mapping, which needs both positive and negative longitudinal magnetization T1rho preparations. We propose here a simple magnetization inversion with an adiabatic inversion RF pulse before an established T1ρ preparation module to achieve an opposite PC. This approach has been shown to be much less sensitive to B0/B1 field imperfections compared with a traditional approach of reversing the phase of the last 90° RF pulse.
Initial Evaluation of a Transverse Isotropic Finite Difference Model for Training Learned Inversion
Authors: Trevathan Jonathan , Scott Jonathan , Trzasko Joshua , Manduca Armando , Huston John , Ehman Richard , Murphy Matthew
Published: August 2023

While most existing inversion algorithms used in MR elastography assume that the mechanical properties of tissue are isotropic, many tissues exhibit spatial anisotropy in structure that is not accommodated by these algorithms.1,2 In this work we present a framework for developing a learned inversion to address transverse isotropy, the simplest anisotropic case. A transversely isotropic stiffness matrix was used in a feed forward finite difference model to generate simulated displacements. The squared wave speeds anisotropic inclusions were calculated using direct inversion to validate the model against the theoretical wave speeds.3
Simultaneous Time-of-Flight (TOF) MR Angiography, SWI and QSM without compromising TOF features
Authors: De Ashmita , Grenier Justin , Wilman Alan
Published: August 2023

Multiple-echo gradient echo sequences developed to simultaneously compute TOF-MRA, SWI and QSM in previous studies have either compromised TOF-MRA features or have not computed QSM. In this abstract, images were acquired in healthy volunteers at 3T with different parameter variations of the proposed 3D triple-echo gradient echo sequence with all TOF-MRA features. The effect of TOF-MRA features on phase and QSM were explored and corrected to obtain artifact-free QSM. The parameters of the sequence have been optimized to obtain TOF-MRA, SWI, QSM and R2* maps simultaneously.
Oxygen Extraction Fraction using Quantitative BOLD and Cerebral Blood Flow during Vasodilation
Authors: Le Linh , Wheeler Gregory , Momjian Alique , Donnay Corinne , Blockley Nicholas , Fan Audrey
Published: August 2023

We quantified brain oxygen extraction fraction (OEF) using quantitative Blood-Oxygenation Level-Dependent (qBOLD) modeling of asymmetric spin echo (ASE) scans acquired at baseline and after pharmacological vasodilation with acetazolamide. In 9 healthy subjects, 60.51±42.00% CBF elevation and -8.45±9.71% OEF decrease in response to vasodilation was observed in multiple gray matter regions in the cortex. The correlation between cerebral blood flow (CBF) and OEF was inversely proportional (p=0.02), indicating complementary vascular responses to the acetazolamide stimulus.
Infarct size and strain by cardiac magnetic resonance predict adverse remodeling after ST-segment elevation myocardial infarction
Authors: Cui Jianing , Li Tao , Zhao Yanan , Yue Xiuzheng
Published: August 2023

Over the past few decades, all-cause mortality and cardiovascular events have remained high in ST-segment elevation myocardial infarction (STEMI) patients. One of the reasons for this is that adverse LV remodeling of the heart that occurs in many patients after myocardial infarction. Cardiac magnetic resonance (CMR) imaging has become a beneficial imaging modality to assess myocardial morphology, LV function and infarct characteristics simultaneously. This study analyzed the value of LV volumes, LV function and infarct characteristics by CMR predicting adverse LV remodeling after STEMI. Our data showed that total enhanced volume was the most accurate prediction parameter.
Relationship between Infarct size, strain and infarct site in patients with ST-segment elevation myocardial infarction
Authors: Cui Jianing , Li Tao , Zhao Yanan , Wang Wei , Liu Wenjia , Chen Yundai , Qian Geng , Yue Xiuzheng , Wang Yishi
Published: August 2023

Effective risk assessment and stratification are essential for the clinical management of ST-segment elevation myocardial infarction (STEMI) patients. CMR imaging has become a beneficial imaging modality to assess myocardial morphology, function and infarct characteristics simultaneously. This study quantitatively evaluated the relationship between infarct size, regional myocardial function by cardiac magnetic resonance feature tracking strain analysis and infarct location in patients with STEMI treated by primary percutaneous coronary intervention. Our data showed that myocardial damage was more extensive and regional myocardial function in infarct zone was lower in the anterior wall myocardial infarction group compared to non-anterior wall myocardial infarction group.
T1ρ dispersion imaging on 3T MRI detects diffuse fibrosis in subtypes of hypertrophic cardiomyopathy
Authors: Wang Keyan , Zhang Wenbo , Li Shuman , Jin Hongrui , Jin Yanan , Jin Yanan , Wang Li , Li Ran , Yang Yang , Cheng Jingliang , Zheng Jie , An Jing
Published: August 2023

This study evaluated a cardiac T1ρdispersion mapping technique, termed as myocardial fibrosis index (mFI), to distinguish various levels of fibrosis in different subtypes of hypertrophic cardiomyopathy (HCM). These subtypes included patients with or without obstructive HCM, and with or without hypertrophic myocardial segments. Our data demonstrated that the mFI is equal to or significantly better than other cardiac fibrosis index, contrast-derived extracellular volumes, and native T1 values.
Co-registration of cardiac PET and late gadolinium enhancement MRI for integrated PET/MR
Authors: zhang zheng , Chen Xing , You Zhiwen , Yuan Jianmin , hu Lingzhi , Zhao Jun , Hu Chenxi
Published: August 2023

A two-stage cardiac PET/late gadolinium enhancement (LGE) co-registration method proposed here significantly improved the co-registration between PET and LGE in integrated PET/MR imaging. The two-stage method led to increased registration score (4.93±0.89) versus no-registration (3.49±0.84, p<0.001) and a single-stage method (4.23±0.81, p<0.001), an increased SUV value in the normal myocardium (3.87±2.56) compared with the no-registration (3.14±1.92, p<0.001) and the single-stage method (3.32±2.16, p<0.001). The technique may improve diagnostic accuracy of non-ischemic cardiomyopathies via better image co-registration.
The Reliability of CMR Fast Late Gadolinium Enhancement Sequence in The Evaluation of Patients with Acute Myocardial Infarction
Authors: jinshui li , yi he
Published: August 2023

By comparing the three kinds of LGE images of 110 patients with AMI, and taking the current standard turbo FLASH imaging sequence as reference, this study verified the accuracy of using moco bSSFP and TrueFISP to evaluate the lesions in patients with AMI. The research covers image quality evaluation and qualitative diagnosis accuracy evaluation. The results show that moco bSSFP sequence and TrueFISP sequence have equivalent effect as turbo FLASH sequence in the qualitative diagnosis, but their image quality is better than that of turbo FLASH sequence.
FLEXA 3DTOF: Fast 3D TOF MR Angiography using Thin-slab Two-Point Dixon Acquisition
Authors: Takei Naoyuki , Amemiya Shiori , Ueyama Tsuyoshi , Fujii Keita , Abe Osamu , Wakayama Tetsuya
Published: August 2023

Conventional 3DTOF MOTSA MRA technique without contrast agent is an established technique for carotid artery examination. The scan time is relatively long to have opportunity to improve. We have explored 3DTOF with two-point Dixon acquisition to achieve faster scan time by optimizing scan parameters and dealing with Water-Fat swap issue where B0 inhomogeneity and strong susceptibility exist at off-center scan in multi-slab acquisitions. The proposed Dixon MRA offers an alternative approach to conventional 3DTOF with about 4.2 times faster acquisition and better image contrast between artery and muscle for carotid MRA.
Evaluation of Coronary Artery Damage in Kawasaki Disease with Non-Contrast Whole-Heart Coronary Magnetic Resonance Angiography
Authors: Ma Yurong , Liang Juan , Han Na , Ai Kai , Zhang Jing
Published: August 2023

In this study, the non-contrast whole-heart coronary magnetic resonance angiography (NCE-CMRA) is used to evaluate the coronary artery damage in Kawasaki Disease (KD). The NCE-CMRA and ultrasound images of children with Kawasaki disease (KD) are retrospectively analyzed. Compared with echocardiography, the NCE-CMRA has its unique advantages in displaying coronary artery, such as high image resolution, good soft tissue contrast and strong signal to noise ratio. Furthermore, NCE-CMRA can clearly and directly show the damaged coronary artery. Therefore, it is a potential alternative to ultrasound for imaging of the coronary artery in children with KD.
PANDA: Simultaneous Phase-Contrast Bright and Dark-blood Angiography for Improvement of Carotid Plaque Assessment
Authors: Murayama Daichi , Sakai Takayuki , Yoneyama Masami , Kwon Jihun , Ochi Shigehiro
Published: August 2023

TOF-MRA sometimes cannot delineate the vessel clearly depending on the vessel orientation. Additionally, insufficient fat suppression can occur in FS-T1-VISTA, it may obscure the plaque depiction. we have developed a new sequence, termed Phase-contrast ANgiography with Dark-blood Application (PANDA), which can simultaneously acquire bright-blood image (MRA) and vessel-wall images (VWI) using the phase contrast method. There was no difference in the visualization ability of carotid plaque between PANDA-VWI and FS T1 VISTA. PANDA-MRA better visualized around the aorta compared to TOF-MRA. PANDA is useful method for simultaneous acquisition of MRA and VWI images.
Comparative analysis of the imaging quality in magnetic resonance coronary angiography with 3D mDIXON and B-TFE sequence on 3T
Authors: Zhang Gang , Xing Wei , Li Tingting , Zheng Yan , Huang Ying , He Junjing , Yue Xiuzheng
Published: August 2023

Due to the narrow diameter, tortuous route of coronary arteries, and the interference of respiration and heartbeats during scanning, MR coronary angiography (MRCA) remains challenge. In 3.0T MR systems, an improved 3D Balanced Turbo Field Echo (B-TFE) sequence is often used for MRCA[1,2], however, 3D mDIXON sequences have been applied for clinical application recently.[3,4] In this study, the subjective imaging quality, objective imaging quality and image authenticity indexes of MRCA with two imaging sequences were compared to analysis. Results showed that B-TFE had better subjective evaluation than mDixon, but mDIXON had better objective quality evaluation for SNR and CNR.
iZoom with 2nd order flow compensated diffusion for Improving cardiac diffusion imaging: a preliminary study
Authors: Wu Zhigang , Zhang Yajing , Hu Xiuquan , Zhang Jing , Zeng Fei , Xu Xiaofang , Jiang Guangyu , Zhao Yan , Gilbert Guillaume , Wang Jiazheng
Published: August 2023

Diffusion MRI could provide unique information non-invasively. However, it is still a technical challenge due to the intrinsic non-rigid motion during the cardiac cycle, displacement of the myocardium due to respiratory motion, field inhomogeneity, and short T1 and T2 values. Parallel imaging and Zoom imaging based on 2D RF (iZoom) could both reduce the distortion dramatically, second order flow compensated diffusion could be used to decrease the impact of motion. We propose a solution that combines iZoom, SENSE and the 2nd flow compensated diffusion to generate a robust cardiac diffusion MRI, its robustness was validated by a preliminary study.
Comparison of the Accuracy between High-resolution B-TFE and 3D T1-FFE MR Sequences on Human Spinal Artery Lesions
Authors: Liao Yunjie , Zhao Chen
Published: August 2023

Spinal artery imaging has long been difficult in clinical detection and assessment of spinal vascular lesions, due to its anatomical complexity and very small diameter. Compared with DSA and CT, CE-MRA technology has the advantages of safety, noninvasive and radiation free. Traditional MR sequences, such as TOF and PC, perform poorly with lower SNR. Here, accuracy of B-TFE and 3D T1-FFE sequences were compared to provide radiologists a better choice in the spinal artery scenario. The results indicated that 3D T1-FFE would be preferred than B-TFE. And B-TFE should be used merely when patients are sensitive to contrast media
Can HR-VW-MRI effectively evaluate the treatment effect on patients with MCA atherosclerotic stenosis after recanalization?
Authors: Chen Kunjian , Dou Weiqiang , Wang Xinyi , Mao Huimin , Guo Yu
Published: August 2023

This study mainly explored the feasibility of high-resolution vascular wall magnetic resonance imaging（HR-VW-MRI）in evaluating the treatment effect for patient with middle cerebral artery (MCA) recanalization. We included 21 patients with MCA stenosis diagnosed by DSA. All patients were treated with SeQuent Please drug-coated balloon recanalization and performed with HR-VW-MRI examination. Decreased responsible plaque area, length, enhancement index and lumen stenosis degree were found in MCA postoperatively. Additionally, the lumen stenosis degree evaluated by HR-VW-MRI was highly correlated with DSA. Therefore, HR-VW-MRI could be used as a valuable method to diagnose the effect of vascular recanalization.
Application of Electric Properties Tomography to Ischemic Stroke: Comparison of Conductivity between Infarct and Contralateral Brain
Authors: Rasanjala Onila , Nguyen Nguyen , Kim Joohyun , Kim Eunju , Katscher Ulrich , Baek Byung Hyun , Park Ilwoo
Published: August 2023

We demonstrate the feasibility of obtaining conductivity using EPT from patients with stroke. The ischemic lesion exhibited significantly higher conductivity values than the contralateral brain tissue in the cerebral brain, while the pons and cerebellum showed similar levels of conductivity values between the ischemic lesion and the contralateral brain tissue. The levels of conductivity value appeared to be specific to regions. The infratentorial normal brain exhibited a significantly higher level of conductivity than the supratentorial brain. In addition, the levels of conductivity were significantly different between the ischemic lesions of basal ganglia & thalamus and cerebral hemisphere.
T1 rho mapping and native T1 mapping for endogenous assessment of myocardial fibrosis in hypertrophic cardiomyopathy
Authors: Yin Gang , Dong Zhixiang , Zhao Shihua , Chen Xiuyu , Yang Kai , Jiang Ke , Wu Zhigang
Published: August 2023

This study is to examine the feasibility of T1 rho and native T1 mapping for endogenous detection of diffuse and focal myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM). Results showed that absolute T1 rho increased progressively and significantly from healthy controls to HCM without LGE and then to HCM with LGE, whereas T1 native increased significantly only from healthy controls to HCM with LGE. Besides, both T1 rho and native T1 had moderate correlation with LGE ratio in severe segments.
Predictive value of cardiac magnetic resonance for reverse left ventricular remodeling after acute ST-segment elevation myocardial infarction
Authors: Cui Jianing , Li Tao , Zhao Yanan , Yue Xiuzheng
Published: August 2023

Many ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI) are still exposed to a consequence known as left ventricular (LV) remodeling. Most studies have reported that reverse LV remodeling is associated with improved patient outcomes. Cardiac magnetic resonance (CMR) imaging has become a beneficial imaging modality to assess myocardial morphology, LV function and infarct characteristics simultaneously. This study assesses the predictive role of LV volume, LV function and infarct characteristics by CMR on reverse LV remodeling after STEMI. Our data showed that peak CK-MB, extent of MVO volume of LV were independent predictors of reverse LV remodeling.
Time estimation from stroke onset with diffusion-relaxation matrix-based T2 and ADC simultaneous mapping
Authors: Yokota Hajime , Sakai Takayuki , Yoneyama Masami , Uno Takashi
Published: August 2023

Diffusion-relaxation matrix (DRM) sequence consists of dual-echo single-shot DW-EPI. DRM was able to detect acute cerebral infarction as well as conventional DWI, and can simultaneously acquire ADC and T2 values. T2 values in the infarcted area correlated significantly with time since stroke onset, whereas ADC did not. In addition, T2 values could predict whether the infarct was within 4.5, 6, or 16 hours, which are the thresholds for thrombolysis and endovascular treatment.
Motion-resolved and Free-breathing Liver MRF
Authors: Peng Cao , Wang Zuojun , Liu Chenyang , Li Tian , Hui Edward , Cai Jing
Published: August 2023

We developed a motion-resolved and free-breathing liver magnetic resonance fingerprinting (MRF) protocol. The deformation maps were obtained from the first singular image of MRF data. The reconstruction method enforced the consistency of the MRF data with the deformation maps by adding the deformation maps to the encoding matrix. MRF was tested on four healthy volunteers. We demonstrated a motion-resolved MRF with a nominal frame rate of 2.5 Hz for free-breathing liver imaging.
A comparative study of multi-parameters from Gd-EOB-DTPA-enhanced MRI in the assessment of liver function in patients with cirrhosis.
Authors: He Yexin , Shao Jia , Guo Jinxia , Gao Qiang , Xu Cheng
Published: August 2023

Gd-EOB-DTPA-enhanced MRI was used to quantitatively assess liver function benefiting the follow-up of patients with chronic liver disease and the appropriate plan for liver cancer treatment. A systematic multi-parametric analysis with non-enhanced and Gd-EOB-DTPA-enhanced T1 weighted and T1 mapping MRI were conducted to assess the liver function in patients with cirrhosis. Independent factor for differentiation of A+N(normal and Child-Pugh A) and B+C (Child-Pugh B and C) were found to be RE_Liver, T1_Native, T1_Post and ΔT1_Liver, while for differentiation of Child-Pugh B and C were found to be ΔT1_Liver and SIR_Bdult/Muscle. Both combined model with these factors obtained better diagnostic performance.
Jointly grading and microvascular invasion predicting of hepatocellular carcinoma based on multi-task deep learning
Authors: Xie Yanyan , Zhang Lijuan , Wang Guangyi , Zhou Wu
Published: August 2023

The pathological grade and microvascular invasion (MVI) of hepatocellular carcinoma (HCC) are two key factors related to the patient's prognosis. Previous studies usually predict these two factors separately based on medical images. In this study, we propose an end-to-end multi-task deep learning network to simultaneously predict the MVI and grading information. Specifically, we are the first to demonstrate that these two tasks are related and can promote each other in the framework of multi-task deep learning. Experimental results of HCC in Contrast-enhanced MR demonstrate the effectiveness of the proposed method, outperforming the single task learning.
Application of native T1 mapping for distinguishing histopathologic subtypes, grades, and stages of rectal adenocarcinoma
Authors: Li Juan , Nickel Marcel , jingliang cheng , Jinxia Zhu
Published: August 2023

This study evaluated the clinical significance of using native T1 mapping for distinguishing histopathologic subtypes, grades, and stage of rectal adenocarcinoma by measuring parameters such as T1 relaxation time and apparent diffusion coefficient (ADC). The results showed that T1 and ADC values were significantly higher in rectal mucinous adenocarcinoma (MC) compared to non-mucinous rectal adenocarcinoma (AC). In the AC group, T1 values were significantly lower in the low-grade AC than in the high-grade AC. Our findings suggest that native T1 mapping can distinguish histopathologic subtypes of renal adenocarcinoma. Moreover, T1 values distinguish different grades of AC more accurately than ADC values.
Diagnostic Performance of Gd-EOB-DTPA for Hepatocellular Carcinoma Based on LI-RADS v2018, Compared With v2017
Authors: Xing Fei , Zhao Xiance
Published: August 2023

The purpose of this study was to compare the diagnostic performance of the LI-RADS v2017 and v2018 for HCC in patients with cirrhosis using Gd-EOB-DTPA. We retrospectively analyzed Clinical data of 213 patients（246 observations）with cirrhosis who underwent Gd-EOB-DTPA from October 2015 to July 2020 were retrospectively collected. MRI major features were reviewed by two radiologists. The LI-RADS categories were assigned according to v2017 and v2018. Our study showed that Updated LR-5 criteria on Gd-EOB-DTPA, the diagnostic performance of LI-RADS v2018 for diagnosing HCC is superior to v2017, particularly in small HCC (10–19 mm), with a greater sensitivity and similar specificity.
Quantification of multi-organ iron overload using R2* mapping in patients with transfusion-dependent diseases
Authors: Wang Xiaonan , Sun Tongtong , Zhu Jinxia , Kannengiesser Stephan , Ni Hongyan
Published: August 2023

We used R2* mapping to assess iron overload in multiple organs of patients with transfusion-dependent diseases and related the R2* values to transfusion volumes and serum ferritin (SF) levels. The organs assessed included the liver, spleen, pancreas, vertebral bone marrow, and myocardium. The results showed a correlation between the R2* values of multiple organs and between the R2* values of some organs and transfusion volumes. This study revealed differences in the distribution of iron overload in various organs and suggested that transfusion volumes could be used to predict the degree of liver iron overload in patients with transfusion-dependent diseases.
Evaluation of amide proton transfer-weighted imaging and stretch index diffusion imaging for lung cancer staging and its correlation with Ki67
Authors: Feng Pengyang , Meng Nan , Huang Zhun , Fang Ting , Li Ziqiang , Fu Fangfang , Wei Wei , Bai Yan , Yang Yang , Yuan Jianmin , Wang* Meiyun
Published: August 2023

Amide proton transfer-weighted imaging (APTWI) primarily reflects the protein content and acidity information of tissue structures. Stretch index diffusion imaging includes α, DDC values, these parameters reflect the heterogeneous characteristics of tumors. Ki67 is a good indicator to evaluate the proliferative activity of tumor cells. The results showed that APTWI and stretch index diffusion imaging had similar diagnostic performance in the diagnosis of lung cancer staging，and there was a certain correlation between the parameters and Ki67.
Can Gd-EOB-DTPA enhanced MRI effectively in differentiate benign biliary obstruction from malignant obstruction?
Authors: Hu Jinghui , Wang Xiaoxiao , Dou Weiqiang , Ye Jing , Luo Xianfu
Published: August 2023

This study aimed to investigate the feasibility of Gd-EOB-DTPA enhanced MRI in differentiating benign from malignant biliary obstruction at hepatobiliary phase (HBP) images. The liver enhancement ratio (LER) and the functional liver imaging (FLIS) score of benign and malignant biliary obstruction were significantly different. With these findings, Gd-EOB-DTPA enhanced MRI at HBP may be considered with an added clinical value in differentiating benign from malignant biliary obstruction.
Preoperative prediction of microvascular invasion in hepatocellular cancer using computation modeling of interstitial fluid pressure
Authors: Zheng Liyun , Wu Lifang , Yang Chun , Sheng Ruofan , Dai Yongming , Zeng Mengsu
Published: August 2023

Microvascular invasion (MVI) is a well-known major prognostic factor of hepatocellular carcinoma (HCC). Unlike macrovascular invasion, which can be easily identified via imaging before treatment, microvascular invasion (MVI) is visible only at microscopy. This study developed a new method for the noninvasive interstitial fluid pressure (IFP) measurement in HCC patients. Our results revealed that MVI status can be predicted by this IFP model preoperatively,
Bile flow dynamics in patients with cholelithiasis: Evaluation with cine-dynamic MRCP using spatially selective inversion-recovery pulse
Authors: Higashi Mayumi , Tanabe Masahiro , Ito Katsuyoshi
Published: August 2023

We evaluated the changes in the bile flow dynamics in patients with cholelithiasis using cine-dynamic MRCP with a spatially selective IR pulse. The frequency and mean secretion grade of the antegrade bile flow were significantly increased in the gallstone group than in the non-gallstone group, while no significant differences in the frequency and mean secretion grade of the reverse bile flow were found between the two groups. Cine-dynamic MRCP with a spatially selective IR pulse can visualize the changes in the bile flow dynamics in patients with gallstones noninvasively.
Correlation between liver function indexes and T1/T2 relaxation time in patients with liver cirrhosis
Authors: Nan Wang , Song Qingwei , Wang Jiazheng , Sun Peng , Chen Lihua , Liu Ailian
Published: August 2023

Evaluation of liver reserve function is crucial for patients with cirrhosis and is helpful for the determination of the surgical plan formulation, the evaluation of treatment process and prognosis, and the operation of cirrhosis. However, there is still lacking a clinically useable non-invasive technique to measure the abnormality of liver function. The purpose of this study is to investigate the potential correlation between T1/T2 relaxation time and liver function indexes in patients with cirrhosis using MR T1/T2 mapping. We found that there was a moderate correlation between T1/T2 relaxation time and liver function assay indexes in liver cirrhosis.
Quantitative Evaluation of Crohn's Disease Using Native T1 Mapping: A Feasibility Study
Authors: Morimoto-Ishikawa Daisuke , Hyodo Tomoko , Komeda Yoriaka , Fukushima Hiroyuki , Ueda Yu , Miyagoshi Keizou , Saito Shigeyoshi , Ishii Kazunari
Published: August 2023

We investigated the usefulness of native T1 mapping using a modified look-locker inversion recovery (MOLLI) sequence, which can be used to evaluate Crohn's disease (CD). The nativeT1 value was measured by setting an ROI on the intestinal wall of the nativeT1 map containing the short-axis image of the intestine. Simple endoscopic activity score in CD (SES-CD) was used as the reference standard for evaluating CD activity. A strong correlation was found between native T1 value and the SES-CD (r = 0.83; p = 0.001).
Low Variance ADC Technique Reduces Bias of Kidney ADC Values
Authors: Li Qiao , Zhao Xiance , Wu Peng
Published: August 2023

Low variance (LOVA) ADC technique could compensate for gradient linearity errors, delivering consistent ADC values with high accuracy in large FOV. This work aims to investigate if gradient nonlinearity bias can be corrected in evaluating the ADC values of kidney using LOVA ADC technique. Our results verified that the corrective effect exists in both health volunteers and patients with common kidney diseases. With the corrected ADC, we could better estimate the unbiased difference between marginal lesions and central lesions, to better predict biological behavior of tissues and provide useful information for diagnosis and treatment.
Alterations of renal function in patients with diabetic kidney disease: A BOLD and DTI study
Authors: Wei Xiaobao , Hu Runyue , Zhou Xiaoli , Zha Dongqing , Xu Haibo , Wu Xiaoyan , Liu Weiyin
Published: August 2023

Renal damage varies in patients with diabetic kidney disease (DKD). Our study aims to determine the patterns of renal oxygenation changes and microstructural changes by blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) and diffusion tensor imaging magnetic resonance imaging (DTI-MRI) with the deteriorating kidney function.
Non-rigid registration of DIXON images is an accurate method for calculating physiological strain in adipose tissue
Authors: Hatt Alice , Lloyd Robert , Bolsterlee Bart , Bilston Lynne
Published: August 2023

To accurately map the large deformation properties of soft tissues, accurate, in-vivo measurements of internal strain are essential. In this study, the Right Cauchy Green strain of adipose tissue was calculated from displacements generated through the non-rigid registration of mDIXON images under increasing compression. The method was validated by synthetically deforming an uncompressed image with compression. Five real-world datasets were acquired of adipose tissue under increasing compression, which resulted in significant increases in the maximum principal strain (one-way ANOVA, p<0.001). The described method provides an accurate quantification of physiological strains in adipose tissue that is essential for mapping strain-varying viscoelasticity.
T1 mapping with extracellular volume fraction measurement to evaluate histological features of cervical squamous cell carcinoma
Authors: Li Shujian , Liu Jie , Nickel Marcel , Cheng Jingliang , Zhu Jinxia
Published: August 2023

This study investigated the feasibility of extracellular volume fraction (ECV) measurement using T1 mapping to evaluate histological grade, lymphovascular space invasion (LVSI) status, perineural invasion (PNI) status, and Ki-67 proliferation index (PI) of cervical squamous cell carcinoma (CSCC), and to compare T1 mapping with diffusion-weighted imaging (DWI). Results showed that T1 mapping-derived parameters (ΔT1, ECV) can effectively grade and predict CSCC LVSI status, PNI status, and Ki-67 PI, and ADC values can stratify CSCC grading. ECV may represent an effective quantitative imaging biomarker indicating the poor-prognosis histological features of CSCC and may provide incremental diagnostic value beyond qualitative MRI features.
Radiomics based on biparametric MRI for the detection of significant residual prostate cancer after androgen deprivation therapy
Authors: Liu Xiaohang , Chen Zhangzhe , Gu Weijie , Zhou Bingni , Liu Wei , Gan Hualei , Zhang Yong , Zhou Liangping
Published: August 2023

The purpose of this study was to use the radiomics method to differentiate prostate cancer and benign peripheral zone (PZ) tissues and investigate its ability to detect significant residual prostate cancer based on whole-mount pathology. The mean ADC of significant residual lesions was significantly lower than that of CR/MRD, which was significantly lower than that of benign tissues. The efficiency of the radiomics models was similar to that of ADC in distinguishing CR/MRD from benign tissue and distinguishing residual from benign tissue. The radiomics models showed superior efficiency in differentiating significant residual from CR/MRD as compared to ADC.
Application of Multi-Echo DIXON and HISTO quantitative techniques for staging of liver fibrosis in patients with chronic hepatitis B
Authors: Ma Laiyang , Jiang Yanli , Zou Jie , Fan Fengxian , Zhang Jing , Wang Shaoyu
Published: August 2023

The purpose of this study was to evaluate the value of Multi-echo DIXON(6 echo) and HISTO techniques for staging of liver fibrosis in patients with chronic hepatitis B. We found that PDFF% value and R2* value had a certain correlation with liver fibrosis, Multi-echo DIXON and HISTO quantitative techniques may be helpful for staging liver fibrosis.
The ultrashort echo time (UTE) sequence quantifies high liver iron more accurately than the multiecho gradient-recalled echo (GRE).
Authors: Bulanov Petr , Manzhurtseva Evelina , Menshchikov Petr , Tolkalov Artem , Kupriyanov Dmitriy , Tereshchenko Galina , Novichkova Galina
Published: August 2023

The most common MRI sequence for iron overload assessment is Cartesian multiecho gradient-recalled echo (GRE) sequence typically measured in a single breath-hold. However, Breath-holding, is not possible for people who are sedated and is difficult for those who have difficulties with holding their breath for a long period. Ultrashort TE (UTE) imaging is one of the solutions for this challenge. In this method radial data acquisition utilized for free breath scanning. Thus, the main goal of this study is to compare the GRE and UTE sequences on a sample of patients with varying degrees of liver iron overload.
Can combined DWI, IVIM and DKI better differentiate malignant from benign breast lesions with TIC type II?
Authors: Hongjie Wang , Weiwei Wang , Weiqiang Dou , Siqiang Lv , Laimin Zhu , Yueqin Chen , Zhanguo Sun
Published: August 2023

Accurate preoperative prediction of benign and malignant breast lesions is essential in clinical practice. Currently, the diagnostic specificity of DCE-MRI is relatively low for breast lesions with time-intensity-curve (TIC) type-II. Different diffusion-weighted models, including mono-exponential diffusion-weighted imaging (DWI), intravoxel-incoherent-motion diffusion-weighted imaging (IVIM) and diffusion kurtosis imaging (DKI), have been previously reported effective in the differential diagnosis of overall breast lesions. In this study, we found that, compared with DWI alone, combined DWI, IVIM and DKI can better differentiate malignant from benign breast TIC type-II lesions, with IVIM parameter of D and DKI parameter of MK as demonstrated independent influencing factors.
Mean Apparent Propagator-MRI: A Novel Diffusion-Based Approach for Quantitative Assessment of Tumor-Stromal Ratio in Breast Carcinoma
Authors: Zhang Xiang , Jiang Wei , Wang Mengzhu , Yang Zehong , Yan Xu , Yang Guang , Mao Chunping , Shen Jun
Published: August 2023

Mean apparent propagator (MAP)-MRI establishes a robust analytical framework based on the random motion distribution of natural water molecules. This study investigated the application of quantitative parameters derived from MAP-MRI in patients with breast cancer and determined whether MAP-MRI can be adopted as a better method than apparent diffusion coefficient (ADC) from conventional DWI to preoperative diagnosis tumor-stromal ratio. The results suggested that quantitative assessment with MAP-MRI showed superior predictive performance than conventional DWI for preoperative diagnosis of tumor-stromal ratio in patients with breast cancer.
Time-dependent IVIM and non-Gaussian parameters in breast cancer and melanoma xenograft models; correlation with histological markers
Authors: Someya Yuko , Iima Mami , Imai Hirohiko , Nobashi Tomomi , Yoshizawa Akihiko , Kataoka Masako , Isoda Hiroyoshi , Le Bihan Denis , Nakamoto Yuji
Published: August 2023

Time-dependent IVIM and non-Gaussian diffusion parameters might provide additional information over conventional DWI to evaluate features linked to tissue microstructure. Time-dependent IVIM and non-Gaussian diffusion parameters were evaluated both in-vivo and post-mortem in MDA-MB-231 (breast cancer) and B16 (melanoma) models. As expected, fIVIM values significantly dropped from in-vivo to post-mortem conditions with both models at two different diffusion times, confirming the association between fIVIM and tumor perfusion, but did not reach 0, suggesting limitations in the IVIM/non-Gaussian Kurtosis model. ADCo values significantly decreased at long diffusion times and upon sacrification while Kurtosis moderately increased.
Application of ultra-high b value diffusion weighted aquaporin imaging for discrimination of prostate cancer from benign prostatic hyperplasia
Authors: Liu Yunsong , Chen Lihua , Wang Jiazheng , Lin Liangjie , Wu Zhigang , Liu Ailian
Published: August 2023

In this study, the ADC value (AQP-ADC) fitted by ultra-high b value diffusion weighted images (UHB-DWI) was used for discrimination between prostate cancer (PCa) from benign prostatic hyperplasia (BPH). The AQP-ADC value was observed to significantly higher in PCa than in BPH. And AQP-ADC may serve as a potential biomarker for differentiation between benign and malignant prostate lesions.
Changes in Apparent Diffusion Coefficient (ADC) in Serial Weekly MRI During Radiotherapy in Patients with Head and Neck Cancer (PREDICT-HN study)
Authors: Ng Sweet Ping , Cardenas Carlos , Bahig Houda , Wang JiHong , Johnson Jason , Yuan Ying , Moreno Amy , Fuller Clifton
Published: August 2023

We evaluated the weekly ADC kinetics of tumour during radiotherapy for head and neck cancer in the PREDICT-HN study. of 41 patients, 36 had intact primary tumours, and 31 patients had nodal disease with 46 nodes assessed. For primary tumours, a steep increase in ADC values from pre-treatment to week 2, and from weeks 5 to post-treatment was observed. For nodes, ADC values increased from pre-treatment to week 4, and then decreased thereafter. A discrepancy in the trajectory of ADC changes between primary and nodal sites suggesting that they exhibit different treatment responses.