bluuebunny/crossref_metadata_2025 huggingface dataset:
Human bone marrow-derived mesenchymal stromal cells cultured in serum-free media demonstrate enhanced antifibrotic abilities via prolonged survival and robust regulatory T cell induction in murine bleomycin-induced pulmonary fibrosis
Authors: Takao Shun , Nakashima Taku , Masuda Takeshi , Namba Masashi , Sakamoto Shinjiro , Yamaguchi Kakuhiro , Horimasu Yasushi , Miyamoto Shintaro , Iwamoto Hiroshi , Fujitaka Kazunori , Hamada Hironobu , Takahashi Shinya , Nakashima Ayumu , Hattori Noboru
Published: September 2021

Background

Mesenchymal stromal cells (MSCs) are a potential therapeutic tool for pulmonary fibrosis. However, ex vivo MSC expansion using serum poses risks of harmful immune responses or unknown pathogen infections in the recipients. Therefore, MSCs cultured in serum-free media (SF-MSCs) are ideal for clinical settings; however, their efficacy in pulmonary fibrosis is unknown. Here, we investigated the effects of SF-MSCs on bleomycin-induced pulmonary inflammation and fibrosis compared to those of MSCs cultured in serum-containing media (S-MSCs).

Methods

SF-MSCs and S-MSCs were characterized in vitro using RNA sequence analysis. The in vivo kinetics and efficacy of SF-MSC therapy were investigated using a murine model of bleomycin-induced pulmonary fibrosis. For normally distributed data, Student’s t test and one-way repeated measures analysis of variance followed by post hoc Tukey’s test were used for comparison between two groups and multiple groups, respectively. For non-normally distributed data, Kruskal–Wallis and Mann–Whitney U tests were used for comparison between groups, using e Bonferroni’s correction for multiple comparisons. All tests were two-sided, and P < 0.05 was considered statistically significant.

Results

Serum-free media promoted human bone marrow-derived MSC expansion and improved lung engraftment of intravenously administered MSCs in recipient mice. SF-MSCs inhibited the reduction in serum transforming growth factor-β1 and the increase of interleukin-6 in both the serum and the bronchoalveolar lavage fluid during bleomycin-induced pulmonary fibrosis. SF-MSC administration increased the numbers of regulatory T cells (Tregs) in the blood and lungs more strongly than in S-MSC administration. Furthermore, SF-MSCs demonstrated enhanced antifibrotic effects on bleomycin-induced pulmonary fibrosis, which were diminished by antibody-mediated Treg depletion.

Conclusions

SF-MSCs significantly suppressed BLM-induced pulmonary inflammation and fibrosis through enhanced induction of Tregs into the lungs and corrected the dysregulated cytokine balance. Therefore, SF-MSCs could be a useful tool for preventing pulmonary fibrosis progression without the demerits of serum use.
The hepatic senescence-associated secretory phenotype promotes hepatocarcinogenesis through Bcl3-dependent activation of macrophages
Authors: Huang Yihua , Yang Xue , Meng Yan , Shao Changchun , Liao Jianping , Li Fengwei , Li Rong , Jing Yingying , Huang Aimin
Published: September 2021

Background

Liver cancer is one of the most common malignancies in the world with a poor prognosis. Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 80–90% of cases. The initiation and progression of HCC are closely associated with chronic liver inflammation. In addition, HCC is often accompanied by cell senescence. Senescent hepatocytes can secrete various inflammatory factors, collectively called the senescence-associated secretory phenotype (SASP). The SASP has been confirmed to promote the occurrence of liver cancer by affecting the inflammatory microenvironment. However, its role and the underlying mechanism of hepatic SASP in hepatocarcinogenesis are not clearly understood. Therefore, a better understanding of the pathogenic mechanisms of the effect of the hepatic SASP on the occurrence of HCC is still needed.

Methods

The study aims to explore the role of SASP factors and the underlying mechanism in tumorigenesis and the progression of HCC in vivo. We used diethylnitrosamine (DEN) combined with carbon tetrachloride (CCl4) (DEN-CCl4) to establish liver cancer model in wild-type (WT) mice and Bcl3 knockout (Bcl3−/−) mice. β-galactosidase (β-gal) staining was performed to evaluate the degree of cellular senescence. Immunohistochemistry (IHC) were used to detect the degree of cellular senescence and the activation of macrophage. PCR chip and clinical tissue chip assays were used to estimate the RNA levels of SASP factors and NF-κB related genes, and their protein levels were examined by Western blot assays.

Results

DEN-CCl4 induced cellular senescence in mouse hepatocytes. In addition, senescent hepatocytes might release a variety of inflammatory factors that further activate macrophages, thereby changing the microenvironmental state and promoting the occurrence of HCC. Mechanistically, the NF-κB pathway is important because it regulates the SASP. Therefore, we used a PCR chip to detect the expression of NF-κB-related genes in senescent liver tissue. Our results showed that the expression of Bcl3 was increased in senescent hepatocytes, and knocking out Bcl3 significantly inhibited the secretion of hepatocyte SASP factors and the activation of macrophages, thereby inhibiting hepatocarcinogenesis. Finally, in clinical tissues adjacent to HCC tissues in patients, the expression of Bcl3 and IL-8 correlated with poor prognosis in HCC patients.

Conclusion

The hepatic SASP can further induce the activation of macrophages during hepatocarcinogenesis, thereby promoting the occurrence of HCC, and that this process is closely related to the expression of Bcl3 in hepatocytes.
Measuring COVID-19 vaccination coverage: an enhanced age-adjusted two-step floating catchment area model
Authors: Mohammadi Alireza , Mollalo Abolfazl , Bergquist Robert , Kiani Behzad
Published: September 2021

Background

There are only limited studies on access to COVID-19 vaccines and identifying the most appropriate health centres for performing vaccination in metropolitan areas. This study aimed to measure potential spatial access to COVID-19 vaccination centres in Mashhad, the second-most populous city in Iran.

Methods

The 2021 age structure of the urban census tracts was integrated into the enhanced two-step floating catchment area model to improve accuracy. The model was developed based on three different access scenarios: only public hospitals, only public healthcare centres and both (either hospitals or healthcare centres) as potential vaccination facilities. The weighted decision-matrix and analytic hierarchy process, based on four criteria (i.e. service area, accessibility index, capacity of vaccination centres and distance to main roads), were used to choose potential vaccination centres looking for the highest suitability for residents. Global Moran’s index (GMI) was used to measure the spatial autocorrelation of the accessibility index in different scenarios and the proposed model.

Results

There were 26 public hospitals and 271 public healthcare centres in the study area. Although the exclusive use of public healthcare centres for vaccination can provide the highest accessibility in the eastern and north-eastern parts of the study area, our findings indicate that including both public hospitals and public healthcare centres provide high accessibility to vaccination in central urban part. Therefore, a combination of public hospitals and public healthcare centres is recommended for efficient vaccination coverage. The value of GMI for the proposed model (accessibility to selected vaccination centres) was calculated as 0.53 (Z = 162.42, P < 0.01). Both GMI and Z-score values decreased in the proposed model, suggesting an enhancement in accessibility to COVID-19 vaccination services.

Conclusions

The periphery and poor areas of the city had the least access to COVID-19 vaccination centres. Measuring spatial access to COVID-19 vaccination centres can provide valuable insights for urban public health decision-makers. Our model, coupled with geographical information systems, provides more efficient vaccination coverage by identifying the most suitable healthcare centres, which is of special importance when only few centres are available.

Graphic abstract
Pica behaviors in schizophrenia: a call for further research
Authors: Khosravi Mohsen
Published: September 2021

Pica as a scavenging behavior represents a serious health hazard to the care of patients with schizophrenia. Despite the rare comorbidity of pica eating disorder and schizophrenia, pica behaviors are relatively common in this group of patients (1.5% vs. 14.3%). The risk of multiple clinical problems such as electrolyte disturbances, intestinal obstruction, and heavy metal poisoning has made pica behaviors an important research topic in patients with schizophrenia. However, few studies have examined the etiology, mechanisms, and treatment of pica behaviors in schizophrenia. This letter is a call for further research into discovering the biopsychopathology of these major clinical manifestations among patients with schizophrenia.
Successful revision surgery for very late-onset stomal obstruction following Gomez gastroplasty: a case report
Authors: Hojo Yudai , Kurahashi Yasunori , Tomita Toshihiko , Kumamoto Tsutomu , Nakamura Tatsuro , Ishida Yoshinori , Shinohara Hisashi
Published: September 2021

Background

Gomez gastroplasty, which was developed in the 1970s as one of the gastric restrictive surgeries for severe obesity, partitions the stomach using a stapler from the lesser towards the greater curvature at the upper gastric body, leaving a small channel. This procedure is no longer performed due to poor outcomes, but surgeons can encounter late-onset complications even decades after the surgery. Here, we report a case of very late-onset stomal obstruction following Gomez gastroplasty which was successfully treated by revision surgery.

Case presentation

A 58-year-old man was referred to our institution with sudden-onset nausea and vomiting. He underwent weight loss surgery in the USA in 1979, but the details of the surgery were unclear. Esophagogastroduodenoscopy demonstrated a stoma at the greater curvature of the upper gastric body, and fluoroscopy showed retention of contrast medium in the fundus and poor outflow through the stoma. Abdominal computed tomography revealed a staple line partitioning the stomach. Considering these preoperative investigation findings and the period during which the surgery was performed, the patient was diagnosed with very late-onset stomal obstruction following Gomez gastroplasty. Supporting the preoperative diagnosis, the surgical findings revealed a staple line extending from the lesser towards the greater curvature of the upper gastric body and a channel reinforced by a running seromuscular suture on the greater curvature. Moreover, gastric torsion caused by the enlarged proximal gastric pouch was found. Re-gastroplasty involving wedge resection of the original channel was performed followed by construction of a new channel. Postoperative course was uneventful, and the patient no longer had symptoms of stomal obstruction after revision surgery.

Conclusions

Re-gastroplasty was safe and feasible for very late-onset stomal obstruction following Gomez gastroplasty. Accurate preoperative diagnosis based on the patient’s interview and the investigation findings was important for surgical planning. A careful follow-up is required to prevent excessive weight regain after revision surgery.
Video Analysis and Verification of Direct Head Impacts Recorded by Wearable Sensors in Junior Rugby League Players
Authors: Carey Lauchlan , Terry Douglas P. , McIntosh Andrew S. , Stanwell Peter , Iverson Grant L. , Gardner Andrew J.
Published: September 2021

Background

Rugby league is a high-intensity collision sport that carries a risk of concussion. Youth athletes are considered to be more vulnerable and take longer to recover from concussion than adult athletes.

Purpose

To review head impact events in elite-level junior representative rugby league and to verify and describe characteristics of X-patchTM-recorded impacts via video analysis.

Study Design

Observational case series.

Methods

The X-patchTM was used on twenty-one adolescent players (thirteen forwards and eight backs) during a 2017 junior representative rugby league competition. Game-day footage, recorded by a trained videographer from a single camera, was synchronised with X-patchTM-recorded timestamped events. Impacts were double verified by video review. Impact rates, playing characteristics, and gameplay situations were described.

Results

The X-patchTM-recorded 624 impacts ≥ 20g between game start and finish, of which 564 (90.4%) were verified on video. Upon video review, 413 (73.2%) of all verified impacts ≥ 20g where determined to be direct head impacts. Direct head impacts ≥ 20g occurred at a rate of 5.2 impacts per game hour; 7.6 for forwards and 3.0 for backs (range = 0–18.2). A defender’s arm directly impacting the head of the ball carrier was the most common event, accounting for 21.3% (n = 120) of all impacts, and 46.7% of all “hit-up” impacts. There were no medically diagnosed concussions during the competition.

Conclusion

The majority (90.4%) of head impacts ≥ 20g recorded by the X-patchTM sensor were verified by video. Double verification of direct head impacts in addition to cross-verification of sensor-recorded impacts using a secondary source such as synchronised video review can be used to ensure accuracy and validation of data.
Position paper: GPT conjecture: understanding the trade-offs between granularity, performance and timeliness in control-flow integrity
Authors: Wang Zhilong , Liu Peng
Published: September 2021

Performance/security trade-off is widely noticed in CFI research, however, we observe that not every CFI scheme is subject to the trade-off. Motivated by the key observation, we ask three questions: ➊ does trade-off really exist in different CFI schemes? ➋ if trade-off do exist, how do previous works comply with it? ➌ how can it inspire future research? Although the three questions probably cannot be directly answered, they are inspiring. We find that a deeper understanding of the nature of the trade-off will help answer the three questions. Accordingly, we proposed theGPTconjecture to pinpoint the trade-off in designing CFI schemes, which says that at most two out of three properties (fine granularity, acceptable performance, and preventive protection) could be achieved.
Facilitators and barriers to clinical practice guideline-consistent supportive care at pediatric oncology institutions: a Children’s Oncology Group study
Authors: Sugalski Aaron J. , Lo Tammy , Beauchemin Melissa , Grimes Allison C. , Robinson Paula D. , Walsh Alexandra M. , Santesso Nancy , Dang Ha , Fisher Brian T. , Wrightson Andrea Rothfus , Yu Lolie C. , Sung Lillian , Dupuis L. Lee
Published: September 2021

Background

Clinical practice guideline (CPG)-consistent care improves patient outcomes, but CPG implementation is poor. Little is known about CPG implementation in pediatric oncology. This study aimed to understand supportive care CPG implementation facilitators and barriers at pediatric oncology National Cancer Institute (NCI) Community Oncology Research Program (NCORP) institutions.

Methods

Healthcare professionals at 26 pediatric, Children's Oncology Group-member, NCORP institutions were invited to participate in face-to-face focus groups. Serial focus groups were held until saturation of ideas was reached. Supportive care CPG implementation facilitators and barriers were solicited using nominal group technique (NGT), and implementation of specific supportive care CPG recommendations was discussed. Notes from each focus group were analyzed using a directed content analysis. The top five themes arising from an analysis of NGT items were identified, first from each focus group and then across all focus groups.

Results

Saturation of ideas was reached after seven focus groups involving 35 participants from 18 institutions. The top five facilitators of CPG implementation identified across all focus groups were organizational factors including charging teams with CPG implementation, individual factors including willingness to standardize care, user needs and values including mentorship, system factors including implementation structure, and implementation strategies including a basis in science. The top five barriers of CPG implementation identified were organizational factors including tolerance for inconsistencies, individual factors including lack of trust, system factors including administrative hurdles, user needs and values including lack of inclusivity, and professional including knowledge gaps.

Conclusions

Healthcare professionals at pediatric NCORP institutions believe that organizational factors are the most important determinants of supportive care CPG implementation. They believe that CPG-consistent supportive care is most likely to be delivered in organizations that prioritize evidence-based care, provide structure and resources to implement CPGs, and eliminate implementation barriers.

Trial registration

ClinicalTrials.gov Identifier: NCT02847130. Date of registration: July 28, 2016.
Can nasal nitric oxide be a biomarker to differentiate allergic and non-allergic rhinitis?
Authors: Kalpaklioglu A. F. , Baccioglu A. , Yalim S. A.
Published: September 2021

Background

Nasal nitric oxide (nNO), a noninvasive indicator for eosinophilic airway inflammation, has not been adequately studied in different types of rhinitis. The aim of this study was to compare nNO levels between allergic (AR) and non-allergic rhinitis (NAR). Patients were included based on their chronic nasal symptoms. Total nasal symptoms score (TNSS) were evaluated. nNO was measured transnasally with a flow of 5 ml/s from the nostril with an NO analyzer (NIOX MINO; Aerocrine, Sweden). Results were evaluated as parts per billion (ppb).

Results

Four hundred forty-three patients (277 F/166 M)—337 with AR (76%) and 106 with NAR (24%)—were assessed. Patients with AR had significantly higher TNSS, more severe disease, and longer duration of disease compared to NAR group. Allergic rhinitis had significantly higher nNO levels than NAR (370 ppb vs 290 ppb) (p = 0.001). Likewise, significant differences were observed in female gender, in patients with BMI ≥ 25 kg/m2 and those without sinusitis between the two groups. When nNO were further evaluated in comorbid asthma, patients with AR w/o asthma had the highest TNSS and had significantly higher nNO level (p < 0.001). NAR+A group, with the longest duration of rhinitis, was significantly older and had the lowest nNO level (p < 0.001).

Conclusions

This study showed that nNO levels were significantly higher in AR patients than NAR. Although there is no recommended standard threshold for nNO, this study confirmed the utility of nNO in differentiating AR and NAR in addition to its known fast and non-invasive advantages.
Disproportionate Negative Impact of the Radiation Oncology Alternative Payment Model on Rural Providers: A Cost Identification Analysis of Medicare Claims
Authors: Mantz Constantine A. , Thaker Nikhil G. , Pendyala Praveen , Hubbard Anne , Eichler Thomas J. , Shah Chirag , Orio Peter F. , Petereit Daniel G.
Published: September 2021

PURPOSE:

The Radiation Oncology Alternative Payment Model (APM) is a Medicare demonstration project that will test whether prospective bundled payments to a randomly selected group of physician practices, hospital outpatient departments, and freestanding radiation therapy centers reduce overall expenditures while preserving or enhancing the quality of care for beneficiaries. The Model follows a complicated pricing methodology that blends historical reimbursements for a defined set of services made to professional and technical providers to create a weighted payment average for each of 16 cancer types. These averages are then adjusted by various factors to determine APM payments specific to each participating provider.

METHODS:

This impact study segregates APM participants into rural and urban groups and analyzes the effect of the Radiation Oncology Alternative Payment Model on their fee-for-service reimbursements.

RESULTS:

The main findings of this study are (1) the greater net-negative revenue impact on rural facilities versus urban facilities that would have participated in the Model this year and (2) the relative lack of high-value treatment services (ie, stereotactic radiotherapy and brachytherapy) delivered by rural facilities that exacerbates their negative impact.

CONCLUSION:

As such, rural providers participating in the Model in its current form may face greater risk to their economic viability and greater difficulty in funding technology improvements necessary for the achievement of high-quality care compared with their urban counterparts.
The effects of temperature and exogenous auxin on cutting propagation of some junipers
Authors: Güney Deniz , Chavoshi Seyyed Hossein , Bayraktar Ali , Atar Fahrettin
Published: September 2021

From past to the present, cultural, medicinal, landscape and culinary use of junipers has contrib­uted to it being one of the most widely distributed woody plants in the world. Therefore, it is so important that finding appropriate production methods to obtain quality seedlings in line with the usage area. In the present study, it was tried to determine the best conditions and applications on propagation by cuttings of three juniper taxa including Juniperus communis L. ‘Hibernica’, Juniperus chinensis L. ‘Stricta’, and Juniperus chinensis L. ‘Stricta Variegata’. For this purpose, two different greenhouse treatments (Greenhouse-1 with the air temperature at 20±2°C, rooting table temperature at 25±2°C and humidity level at 70±2%; Green­house-2 with the air temperature at 20±2°C, rooting table temperature at 20±2°C and humidity level at 70±2%) and different auxin applications (Indole-3-Butyric Acid, Indole-3-Acetic Acid and α-Naphthalene Acetic Acid at concentrations of 3000 and 5000 ppm) were designed. The highest rooting percentages were generally achieved in Greenhouse-1. IAA 5000 ppm treatment for J. communis ‘Hibernica’ (93.33%) and J. chinensis ‘Stricta’ (66.67%, also in Greenhouse-2) and IBA 3000 ppm treatment for J. chinensis ‘Stricta Var­iegata’ (60.00%) showed the best rooting results. This study, in which the best production conditions are investigated in some juniper taxa, is a guiding feature for the producers to ensure the sustainable utilization of junipers.
Articulação administrativa: por uma reforma cultural da administração pública
Authors: Francis dos Santos Maciel Caroline Stéphanie
Published: September 2021

Há algumas décadas, discute-se a necessidade de uma profunda reforma administrativa no Brasil, defendendo-se a adoção de um modelo de administração pública gerencial. No entanto, em alguns níveis, nem sequer houve a transição da administração pública patrimonialista para a burocrática. A tomada de decisões públicas tem sido casuística; voltada a interesses pessoais dos detentores de poder; centralizada, especialmente na União; obscura e sem coordenação entre entidades, órgãos e agentespúblicos. Nesse contexto, este artigo pretende abordar a necessidade de articulação e coordenação administrativas como um passo para se alcançar a efetividade de uma administração pública gerencial, cujas ações e políticas gerem resultados. Serão abordadas, principalmente, as normas do Decreto-Lei nº 200/1967 vigentes sobre o assunto e a proposta do Anteprojeto de normas gerais para a administração pública.
Administração que cala consente? Dever de decidir, silêncio administrativo e aprovação tácita
Authors: Marrara Thiago
Published: September 2021

O artigo aborda os passos do ordenamento brasileiro no combate à omissão de decidir da administração pública. Em seguida, examina a aprovação tácita nos termos previstos pela Lei de Liberdade Econômica e seu Decreto Regulamentar. Abordam-se seus requisitos explícitos e implícitos, as hipóteses de vedação, os efeitos posteriores ao ato fictício e a questão da aplicabilidade do instituto a estados e municípios.
Interações socioestatais no caso da política de valorização do salário mínimo (2003-2011): a crise do mensalão como oportunidade política
Authors: Dos Santos Mahatma Ramos
Published: September 2021

Este artigo investigará como a categoria crise operou - seu status e qualificação -na interação socioestatal entre centrais sindicais e Estado ao longo da negociaçãoda Política de Valorização do Salário Mínimo no Brasil (2003-2011). O estudobaseou-se na articulação das categorias analíticas de interação socioestatal deAbers et al (2014) e de crise de Roitman (2016), assim como na análise documentale realização de dez entrevistas. O artigo conclui que dois eventos - o “mensalão” eo antagonismo no interior do poder executivo federal - operaram, simultaneamente,como crises políticas e espaço para crítica e transformação dos repertórios deinteração socioestatal em si e do repertório de ação política das centrais sindicaisquanto ao salário mínimo nos anos 2000.
Releitura da Política Externa do governo Geisel: o anticomunismo como variável em 1974
Authors: Oliveira Moreira Danilo Sorato
Published: September 2021

O artigo visa apresentar uma releitura sobre a Política Externa do governo Geisel pelavariável do Anticomunismo em 1974. A metodologia utilizará análise qualitativahistórica através de bibliografia especializada e de fontes diplomáticas, dentre elas; odiscurso do presidente da república e a fonte diplomática do “Foreign Office”americano dos anos de 1974. A hipótese argumenta que, embora exista a leiturarealista do ambiente externo pelo “Pragmatismo Ecumênico Responsável”, em âmbitointerno essa leitura foi restringida pela política anticomunista de perseguição aosopositores políticos em 1974. Considera-se que essas escolhas controversas foramconsequências dos limites, que a PEB esteve submetida pelas condicionantesexternas, internas, ideológicas e históricas.
Algumas ideias sobre socialismo e democracia no pensamento de João Mangabeira (1944-1946)
Authors: Anjos Herbert Gler Mendes
Published: September 2021

Esse artigo tem como objetivo evidenciar e analisar algumas ideias e proposiçõespolíticas defendidas por João Mangabeira (1880-1964) durante o período daredemocratização de 1945 e o início da República Liberal Democrática (1945-1964).Analisaremos algumas formulações de Mangabeira relativas às suas ideias de“liberdade”, de “socialismo” e de “democracia”. Nosso objetivo é compreender asideias de Mangabeira em seu contexto histórico-político e tentar entender a influênciase as combinações entre certas ideias no liberalismo clássico e do socialismo em seupensamento.
Os ex-votos de Catarina Paraguaçu: a mulher tupinambá através da arte, do museu e do catolicismo
Authors: Brasil Pedro Henrique
Published: September 2021

O presente artigo aborda a pintura “Visão de Paraguaçu” produzida em meados doséculo XIX pelo pintor Ângelo da Silva Romão, que traz a figura da indígenatupinambá, Catarina Paraguaçu, na Bahia do século XVI. Atualmente é exposta noMuseu Histórico Nacional na cidade do Rio de Janeiro. Duas hipóteses principaisconfiguram a pesquisa: a primeira é sobre a noção de longa duração utilizada para seentender as práticas de produção e circulação de pinturas votivas, os ex-votos, emtorno da representação de Catarina; a segunda se refere ao potencial da peça paraconstituir o acervo, entendendo o Museu como um espaço de memória voltado paraa pluralidade cultural, propondo-se o reconhecimento da importância da personagempara a arte e a história do catolicismo no Brasil.
Imagem e memória em um olhar estratégico sobre o legado de Jean-Michel Basquiat
Authors: Rainho Hélio Ricardo
Published: September 2021

O artigo propõe uma reflexão sobre alguns aspectos possíveis do agenciamento do pintor Jean-Michel Basquiat sobre sua própria imagem em consonância com a narrativa de suas obras, dialogando com os escritos de Georges Didi-Huberman  sobre a sobrevivência da imagem no tempo e de Michael Pollak sobre a questão da memória como uma forma de narrativa estabelecida a partir de um campo de disputa, construção e poder.
O Hip Hop em São Gonçalo (1998-2015): da ASAC à Batalha do Tanque
Authors: Quevedo Gonzaga Klauder Vicente
Published: September 2021

O presente artigo e pesquisa buscam identificar alguns aspectos sobre a prática do fenômeno do Hip Hop na cidade de São Gonçalo, segunda cidade mais populosa do Rio de Janeiro, seus principais articuladores, sua relação com o poder público e com o mercado, emperspectiva local, nacional e transnacional, além de pensar as transformações do movimentoneste território entre os anos 1998 e 2015.
“Eu mesma. Ainda posso falar”: Vozes femininas e cultura política na literatura de Maria Firmina dos Reis
Authors: Bezerril Benigna Ingred Aurelia
Published: September 2021

O presente artigo propõe discutir a produção literária de Maria Firmina dos Reis enquanto espaço de cultura política feminina. Para isso, serão analisados o romance Úrsula (1859) e o conto A Escrava (1887), especificamente os discursos de três personagens femininas: a senhora abolicionista e a escravizada Joana de A Escrava; e a preta Susana, personagem de Úrsula. A partir da análise de tais personagens e de suas narrativas, é possível perceber um protagonismo de vozes subalternas nas obras de Firmina dos Reis, considerando o contexto no qual ela escreveu: o século XIX. Abolicionismo, denúncias ao sistema escravista e o lugar da mulher são temas que entram em pauta no discurso das personagens femininas da escritora.
Raça e trabalho no século XX: a origem das desigualdades raciais no mercado de trabalho brasileiro (1920-1960)
Authors: De Almeida Jesus Anna Cristina
Published: September 2021

O presente estudo objetiva analisar as disparidades raciais que pautaram a formação do mercado de trabalho brasileiro, durante o processo de industrialização do país noséculo XX. Para isso, nos debruçaremos sobre duas obras: “O negro no Rio de Janeiro: Relações de raça numa sociedade em mudança”, publicado por Luiz de Aguiar Costa Pinto e “Negros e brancos em São Paulo” de George Reid Andrews.Ambos os estudos de caso vão demonstrar que, reproduzindo as hierarquias deixadas pela escravidão, a construção do mercado de trabalho livre no Brasil foi pautada pelo racismo estrutural.
Gilberto Velho em perspectiva: a atuação do antropólogo à luz do projeto "Memória das Ciências Sociais no Brasil"
Authors: Oliveira Menezes Costa Anna Beatriz
Published: September 2021

O presente trabalho tem como enfoque a trajetória e o impacto de Gilberto Velho nasCiências Sociais brasileiras, tendo como escopo as entrevistas do projeto “Memóriadas Ciências Sociais no Brasil”. Utilizando a análise de dezesseis depoimentos dessainiciativa como metodologia, procuro demonstrar de que maneira a atuação de Velhoperpassa por diferentes percursos pessoais e acadêmicos e repercute naconsolidação das Ciências Sociais, sobretudo da Antropologia, como uma área dedestaque no Brasil. O pioneirismo da Antropologia Urbana, as relações de orientação,os papéis institucionais e a influência na formação de gerações de pesquisadores sãoos elementos principais da minha linha de argumentação.
A construção de um exilado político: autobiografia e biografia do ex-presidente João Café Filho
Authors: Pereira Fonseca da Cunha Paulo Rikardo
Published: September 2021

Este artigo pretende fazer uma reflexão sobre as tensões teórico metodológicas existentes entre os conceitos de biografia e autobiografia por meio da análise do livro de memórias do ex-presidente Café Filho, procurando entender que tipo de personagem construiu em seus escritos. Pretendemos compreender como uma vida pode se transformar numa autobiografia e quais foram os motivos que levaram esse indivíduo a escrevê-la. Ele descreveu sua trajetória agenciando lembranças e esquecimentos para monumentalizar uma memória de si como político perseguido e exilado. Narrou sua vida de um momento privilegiado, o fim de sua carreira, criando uma história coerente com começo, meio e fim, dando uma linearidade que não existe na trajetória das pessoas.
Clinical Re-evaluation on Bioequivalence and Relative Bioavailability of Micronized Progesterone Hard Capsule (Yimaxin) and Micronized Progesterone Soft Capsule (Utrogestan) under Vaginal and Oral Administration Routes
Authors: Wang Hanbi , Liu Meizhi , Chen Rui , Deng Chenyan
Published: September 2021

Background and Objective: To clinically re-evaluate relative bioavailability and bioequivalence of micronized progesterone (hard capsule) Yimaxin and micronized progesterone (soft capsule) Utrogestan under vaginal and oral administration routes.

Methods: From December 2017 to June 2018, a total of 16 postmenopausal healthy women were recruited and received a total of four rounds of drug treatment with cross-over design, respectively Yimaxin and Utrogestan under vaginal and oral administration routes. Changes in the subjects’ hormone levels after medication were monitored and an endometrial biopsy after a course of treatment was performed in our hospital.

Result: The Geomeans of AUC0-t of Yimaxin and Utrogestan under vaginal administration route were 252.15 and 115.46, respectively, with a ratio of 2.19, and under oral administration route were 244.64 and 413.68, respectively, with a ratio of 0.59. The Geomeans of Cmax of Yimaxin and Utrogestan under vaginal administration route were 28.11 and 12.21, respectively, with a ratio of 2.30, and under oral administration route were 53.12 and 129.85, respectively, with a ratio of 0.41.

Conclusion: Yimaxin was not bioequivalent to Utrogestan. Yimaxin had higher exposure to the drug in vivo at the same dose when administered vaginally, and Utrogestan had higher exposure to the drug in vivo at the same dose when administered orally.

doi: https://doi.org/10.12669/pjms.37.7.3949

How to cite this:Wang H, Liu M, Chen R, Deng C. Clinical Re-evaluation on Bioequivalence and Relative Bioavailability of Micronized Progesterone Hard Capsule (Yimaxin) and Micronized Progesterone Soft Capsule (Utrogestan) under Vaginal and Oral Administration Routes. Pak J Med Sci. 2021;37(7):---------. doi: https://doi.org/10.12669/pjms.37.7.3949

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Εργασιακή ικανοποίηση και δέσμευση
Authors: Γκλιάτη Αλεξάνδρα
Published: September 2021

Είναι εξαιρετικά σημαντικό οι εργαζόμενοι να είναι ικανοποιημένοι από την εργασία τους καθώς αυτό συνεισφέρει σημαντικά στη βελτίωση της παραγωγικότητας και της επίδοσης τους στα πλαίσια του οργανισμού. Η παρούσα έρευνα, εστιάζει στον τομέα της υγείας και συγκεκριμένα στους γιατρούς που εργάζονται στα δημόσια νοσοκομεία της χώρας. Σκοπός της παρούσας έρευνας είναι να διερευνηθούν και να αναλυθούν οι απόψεις του ιατρικού δυναμικού, σε σχέση με την εργασιακή ικανοποίηση και τους παράγοντες που την καθορίζουν, την εργασιακή δέσμευση, την οργανωσιακή υποστήριξη και συναδελφικότητα καθώς και το εάν η οικονομική κρίση έχει επηρεάσει τα επίπεδα εργασιακής ικανοποίησης και δέσμευσης στον ιατρικό κλάδο. Προκειμένου να επιτευχθεί ο σκοπός της μελέτης, πραγματοποιήθηκε εμπειρική έρευνα μέσω της διανομής ανώνυμου ερωτηματολογίου σε ιατρικό δυναμικό που εργάζεται σε δημόσια νοσοκομεία της χώρας και προέρχεται από τις επτά υγειονομικές περιφέρεις. Το ερευνητικό εργαλείο αποτελούταν από: δημογραφικά χαρακτηριστικά, το Minnesota Satisfaction Questionnaire, το Utrecht Work Engagement Scale, ερωτηματολόγια που αναφερόταν στην υποστήριξη από τον προϊστάμενο, τους συναδέλφους, τον οργανισμό, καθώς και ερωτηματολόγιο που αξιολογούσε την επιρροή της οικονομικής κρίσης. Για την ανάλυση των αποτελεσμάτων πραγματοποιήθηκε παραγοντική ανάλυση, υπολογισμός μέσων όρων, έλεγχος συναφειών και οικονομετρικά μοντέλα γραμμικής παλινδρόμησης.Τα αποτελέσματα της έρευνας έδειξαν ότι οι γιατροί είναι σχετικά ικανοποιημένοι από τις περισσότερες πτυχές στην εργασία τους, με σημαντικότερο παράγοντα για την εργασιακή ικανοποίηση να αποτελεί η ίδια η φύση της εργασίας τους και τα υψηλά επίπεδα αυτονομίας που διατηρούν. Επιπροσθέτως, στην έρευνα αυτή φάνηκε ότι οι γιατροί παραμένουν δεσμευμένοι στην εργασία τους και η οικονομική κρίση, παρόλο που έγινε αντιληπτή στην καθημερινότητα τους, δεν επηρέασε τα επίπεδα ικανοποίησης και δέσμευσής τους σημαντικά. Η υποστήριξη από τον προϊστάμενο φάνηκε να είναι πολύ σημαντική για την ανάπτυξη και την πρόβλεψη της εργασιακής ικανοποίησης και της εργασιακής δέσμευσης. Η προερχόμενη από τους συναδέλφους υποστήριξη αποτελεί σημαντικό παράγοντα για την εργασιακή ικανοποίηση ενώ η υποστήριξη από το νοσοκομείο, όπως αυτή γίνεται αντιληπτή από του γιατρούς, μπορεί να επηρεάσει τόσο τα επίπεδα της εργασιακής ικανοποίησης όσο και της εργασιακής δέσμευσης.Συμπερασματικά, παρά την οικονομική κρίση στην Ελλάδα, οι γιατροί μπορούν να παραμείνουν ικανοποιημένοι από την εργασία τους και να είναι δεσμευμένοι σε αυτήν, ενώ οι προϊστάμενοι και τα ίδια τα νοσοκομεία μπορούν μέσω της παροχής υποστήριξης στους γιατρούς να συντελέσουν στην ανάπτυξη της εργασιακής ικανοποίησης και δέσμευσης, δημιουργώντας έτσι τις βάσεις για πολλά θετικά αποτελέσματα για τα νοσοκομεία και τους εργαζόμενους.
Στοιχεία ψυχοπαθολογίας και χαρακτηριστικά προσωπικότητας που σχετίζονται με την έκβαση της νόσου και την ποιότητα ζωής των ασθενών με καρκίνο άγνωστης πρωτοπαθούς εστίας
Authors: Παπαδημητρίου Ηλίας
Published: September 2021

Η μελέτη μας ήταν συγχρονική και συμμετείχαν 50 ασθενείς με καρκίνο άγνωστης πρωτοπαθούς εστίας, 162 ασθενείς με καρκίνο παχέος εντέρου (139 χωρίς μεταστάσεις) και 154 γυναίκες με διεγνωσμένο καρκίνο του μαστού (125 χωρίς μεταστάσεις) που παρόμοια χρονική περίοδο νοσηλεύτηκαν στην Ογκολογική Κλινική. Οι στόχοι της συγχρονικής μας μελέτης ήταν να εκτιμηθεί αρχικά η επίπτωση και η σοβαρότητα συμπτωμάτων ψυχολογικής καταπόνησης σε ασθενείς με ΚΑΠΕ και να ελεγχθεί το κατά πόσο η συχνότητα τους και η ένταση τους διαφέρουν ανάμεσα σε ασθενείς με ΚΑΠΕ και ασθενείς με καρκίνο γνωστής πρωτοπαθούς εστίας, με ή χωρίς μεταστάσεις. Επίσης, στους στόχους της έρευνας, ήταν να εκτιμηθούν οι αναπαραστάσεις για την νόσο των ασθενών, οι μηχανισμοί άμυνας που χρησιμοποιούν, η αίσθηση συνεκτικότητας τους και η συσχέτιση των παραπάνω παραγόντων με την επιβίωση και την σχετιζόμενη με την υγεία ποιότητα ζωής. Η συλλογή των δεδομένων έγινε με τη συμπλήρωση ερωτηματολογίων. Οι ασθενείς με καρκίνο άγνωστης πρωτοπαθούς εστίας εμφάνιζαν υψηλά επίπεδα καταθλιπτικής συμπτωματολογίας και αυξημένη ψυχική επιβάρυνση συγκριτικά με τους ασθενείς με γνωστή πρωτοπαθή καρκίνο, με ή χωρίς μεταστάσεις. Σημαντικό εύρημα ήταν, επίσης, ότι η παρουσία συγκεκριμένων χαρακτηριστικών προσωπικότητας όπως η χαμηλή αίσθηση συνεκτικότητας και η υψηλή διαπροσωπική ευαισθησία, σχετίζονται θετικά με το μειωμένο προσδόκιμο επιβίωσης, ενώ η ποιότητα ζωής των ασθενών επηρεάζεται σε σημαντικό βαθμό από την ύπαρξη καταθλιπτικής συμπτωματολογίας. Τέλος, μελετήσαμε τις αντιλήψεις των ασθενών για την νόσο και δείξαμε ότι παίζουν σημαντικό ρόλο, που αξίζει να διερευνηθεί περαιτέρω, αφού εξασθενούν την επίπτωση των καταθλιπτικών συμπτωμάτων στην ποιότητα ζωής.
Οργανωμένο έγκλημα και διαφθορά
Authors: Καλλίρης Κωνσταντίνος
Published: September 2021

Η σχέση ανάμεσα στο οργανωμένο έγκλημα και τη διαφθορά είναι ευρύτατα καταγεγραμμένη. Συχνά, η διαφθορά συμπεριλαμβάνεται στον ορισμό του οργανωμένου εγκλήματος ως μία από τις συνηθέστατες δραστηριότητες των εγκληματικών οργανώσεων. Αυτή η διατριβή προσφέρει μία ερμηνεία της στρατηγικής επιλογής των εγκληματικών οργανώσεων να καταφεύγουν στη διαφθορά κρατικών αξιωματούχων και δημοσίων λειτουργών. Η παιγνιοθεωρητική προσέγγιση που προκρίνεται αντιμετωπίζει τη διαφθορά ως μία ορθολογική επιλογή από τους δύο εμπλεκόμενους «παίκτες»: τις εγκληματικές οργανώσεις και τα κράτη. Η διαφθορά αναδεικνύεται ως η λιγότερο επιζήμια επιλογή όταν η σχέση ισχύος ανάμεσά τους είναι σχετικά ισορροπημένη. Στο πλαίσιο της ανάπτυξης αυτής της θεωρίας επιχειρείται η περιγραφή των δύο κρίσιμων εννοιών, ήτοι του οργανωμένου εγκλήματος και της διαφθοράς. Οι εγκληματικές οργανώσεις περιγράφονται ως ένας φαινότυπος παραβατικής δράσης που διακρίνεται από παρεμφερείς ομαδικές δραστηριότητες με βασικό κριτήριο το μονοπωλιακό χαρακτήρα της. Η κατανόηση αυτού του χαρακτήρα είναι κρίσιμη για την περιγραφή της θέσης ισχύος από την οποία το οργανωμένο έγκλημα «διαπραγματεύεται» με το κράτος. Η διαφθορά αναλύεται ως ένα φαινόμενο συνεργασίας «με διάθεση αλληλοεξυπηρέτησης», το οποίο εκτείνεται πέραν των οικονομικών συναλλαγών και της σχέσης ανάμεσα στον πολίτη και το δημόσιο. Όταν τόσο οι κρίσιμες έννοιες όσο και η θεωρία συνεργασίας που υποστηρίζεται στη διατριβή έχουν αναλυθεί επαρκώς, επιχειρείται η εμπειρική επιβεβαίωση της τελευταίας με τη βοήθεια μίας υβριδικής συγκριτικής-ιστορικής ερμηνείας, η οποία συνδυάζει την μέθοδο της συμφωνίας και την μέθοδο της διαφοράς. Ως περιπτώσεις που πληρούν τις προϋποθέσεις της πρώτης μεθόδου εξετάζονται η Σικελική Μαφία, η Ιαπωνική Γιάκουζα και το Outfit του Σικάγο. Ως «περίπτωση ελέγχου» εξετάζονται οι συμμορίες («gangs»), οι οποίες μοιράζονται πολλά κοινά χαρακτηριστικά με τις εγκληματικές οργανώσεις αλλά δεν έχουν μονοπωλιακή δράση. Μετά από την επιβεβαίωση των θεωρητικών πορισμάτων της διατριβής, ακολουθεί μία κριτική επισκόπηση της σχετικής νομοθεσίας και προτάσεις αντεγκληματικής πολιτικής.
Η σημασία της ισχαιμίας της ωχράς στις φλεβικές αποφράξεις αμφιβληστροειδούς
Authors: Γιαννούλη Κωνσταντίνα
Published: September 2021

Να μελετηθεί η στιβάδα των φωτοϋποδοχέων, σε οφθαλμούς με κλαδική απόφραξη φλέβας αμφιβληστροειδούς και ισχαιμία ωχράς, χρησιμοποιώντας μία μέθοδο en face optical coherence tomography (OCT) απεικόνισης της ελλειψοειδούς ζώνης.Μέθοδος: Προσαρμοσμένα OCT scans ωχράς, από 9 ασθενείς (10 οφθαλμοί) με κλαδική απόφραξη φλέβας αμφιβληστροειδούς και ισχαιμία ωχράς , εξήχθησαν και επεξεργάστηκαν (αφαίρεση σκιών προερχόμενων από αγγεία και κυστικούς χώρους, διαχωρισμός στιβάδων και ευθειασμός στο επίπεδο του μελάγχρου επιθηλίου). Η ελλειψοειδής ζώνη διαχωρίστηκε, ευθειάστηκε και χρησιμοποιήθηκε για τη δημιουργία της en face OCT εικόνας. Έγινε σύγκριση μεταξύ των υποανακλαστικών περιοχών απώλειας φωτοϋποδοχέων και των ισχαιμικών περιοχών, όπως οι τελευταίες καταγράφηκαν στις πρώιμες φάσεις της φλουοροαγγειογραφίας.Αποτελέσματα: Οι περιοχές απώλειας του τριχοειδικού δικτύου (στη φλουοραγγειογραφία), παρουσίασαν σαφή συσχέτιση με τις περιοχές διαταραχής της ελλειψοειδούς ζώνης (στην en face OCT απεικόνιση). Οι περιοχές διαταραχής της ελλειψοειδούς ζώνης είχαν ανομοιόμορφη εικόνα, και σαφή ή ασαφή όρια, ανάλογα με τη βαρύτητα της βλάβης.Συμπέρασμα: Η en face OCT απεικόνιση της ελλειψοειδούς ζώνης ανέδειξε μία σαφή συσχέτιση μεταξύ της απώλειας του τριχοειδικού δικτύου και των διαταραχών της ελλειψοειδούς ζώνης σε οφθαλμούς με κλαδική απόφραξη φλέβας αμφιβληστροειδούς. Το εν τω βάθει τριχοειδικό δίκτυο προφανώς συμβάλλει σημαντικά στις μεταβολικές ανάγκες του έξω αμφιβληστροειδούς και, κατά συνέπεια, ισχαιμία στο επίπεδο του εν τω βάθει τριχοειδικού δικτύου έχει σοβαρό αντίκτυπο στην ακεραιότητα των φωτοϋποδοχέων.
Μελέτη της δυναμικής συμπεριφοράς των μιτοχονδρίων και των ρυθμιστών τους στην ψωρίαση
Authors: Θεριανού Αναστασία
Published: September 2021

ΠΕΡΙΛΗΨΗΗ ψωρίαση είναι μια φλεγμονώδης νόσος που χαρακτηρίζεται από πολλαπλασιασμό κερατινοκυττάρων και χρόνια φλεγμονή, αλλά η παθογένεση δεν έχει ακόμα αποσαφηνιστεί. Τα μιτοχόνδρια θα μπορούσαν να οδηγήσουν σε μειωμένη απόπτωση και εξωκυτταρική έκκριση του μιτοχονδριακού DNA (mt DNA), το οποίο λειτουργώντας ως "έμφυτο παθογόνο" επάγει την φλεγμονή. Ορός συλλέχθηκε από υγιείς εθελοντές και ασθενείς με ψωρίαση. Το μιτοχονδριακό DNA εκχυλίστηκε από τον ορό και ενισχύθηκε με ποσοτική PCR (qPCR). Βιοψίες δέρματος ελήφθησαν από ψωριασικές πλάκες, μη παθολογικό ψωριασικό δέρμα (10 cm μεταξύ τους) και από δέρμα υγιών εθελοντών, τοποθετήθηκαν σε υγρό RNA later και αποθηκεύθηκαν στους -80 °C μέχρις ότου το RNA εκχυλίστηκε και συντέθηκε cDNA. Η γονιδιακή έκφραση της πρωτεΐνης αποσύνδεσης 2 (UCP2), η σχετιζόμενη με τη δυναμική πρωτεΐνη 1 (Drp1) και η καλσινευρίνη, που εμπλέκονται στη ρύθμιση της λειτουργίας των μιτοχονδρίων, ανιχνεύθηκαν με qPCR. Το μιτοχονδριακό DNA βρέθηκε στατιστικώς σημαντικά αυξημένο (mitochondrial 7s, p = 0,0496 και Cytochrome B, CytB, p = 0,0403) στον ορό των ψωριασικών ασθενών (n = 63) σε σύγκριση με τους μάρτυρες (n = 27). Η γονιδιακή έκφραση για το UCP2 (p = 0.0218), το Drp1 (p = 0.0001) και την καλσινευρίνη (p = 0.0001) βρέθηκε στατιστικώς σημαντικά μειωμένη στις ψωριασικές πλάκες, σε σύγκριση με το μη παθολογικό δέρμα και το δέρμα υγιών μαρτύρων. Το αυξημένο εξωκυτταρικό mtDNA ορού σε ασθενείς με ψωρίαση και η μειωμένη έκφραση των μιτοχονδριακών ρυθμιστικών πρωτεϊνών στο ψωριασικό δέρμα, υποδηλώνουν αυξημένη φλεγμονή και μειωμένη απόπτωση κερατινοκυττάρων, αντίστοιχα. Αναστολείς έκκρισης mtDNA ή/και αγωνιστές της UCP2 μπορεί να είναι πιθανές επιλογές θεραπείας για την ψωρίαση στο μέλλον.
Design and development of a real time bio-sensing system assessing student mental workload and engagement
Authors: Ψάλτης Αντώνιος
Published: September 2021

Ο εντοπισμός του επακριβούς επιπέδου προσήλωσης και εμπλοκής των μαθητών με το περιεχόμενο διδασκαλίας στην τάξη είναι ένας από τους πιο μεγαλεπήβολους στόχους των ερευνητών της εκπαιδευτικής και επιστημονικής κοινότητας. (Lang, 1995, Grossberg, 1987). Σχετικές διεπιστημονικές ερευνητικές προσπάθειες προσαύξησης ενδιαφέροντος και εντοπισμού της αποτελεσματικότητας των διδακτικών πρακτικών βασίζονται σε μελέτες βελτιστοποίησης από τους χώρους της ψυχολογίας, της παιδαγωγικής, της παιδοψυχολογίας και της ψυχοφυσιολογίας. Πρόσφατες προσεγγίσεις, εισάγουν νέες τεχνολογίες χρησιμοποιώντας διαγνωστικές συσκευές δανεισμένες από τον χώρο της ιατρικής με σκοπό να εκμεταλλευτούν τις δυνατότητες μετρήσεων βιολογικών σημάτων. Βιολογικές μετρήσεις όπως αυτές των ρυθμών αναπνοής, καρδιάς και αποκρίσεις του παρασυμπαθητικού νευρικού συστήματος αποτελούν επιβεβαιωμένες εκφράσεις ψυχοφυσιολογικών καταστάσεων οι οποίες εκδηλώνουν καταστάσεις διέγερσης και διάθεσης, (Venables, Christie et al., 1980; Damasio 1994/2006). Οι ιατρικές συσκευές απαιτούν εργαστηριακό περιβάλλον λόγω των αναγκών χρήσης ηλεκτροδίων, κινητικών περιορισμών, συγχρονισμού και ομοιομορφίας των στοιχείων που προκύπτουν και γι’ αυτό τον λόγο δεν μπόρεσαν ποτέ να αποδώσουν μια προσιτή λύση εφαρμόσιμη ευρύτερα σε εκπαιδευτικό περιβάλλον. Στην παρούσα μελέτη, αναλύονται οι επιδόσεις μιας ειδικά κατασκευασμένης ηλεκτρονικής συσκευής, σχεδιασμένης ώστε να εξεταστούν οι δυνατότητες να εξαχθούν δείκτες ψυχοσωματικών εκφράσεων του χρήστη, με την δυνατότητα να χρησιμοποιείται εύχρηστα στην τάξη χωρίς ηλεκτρόδια και επηρεασμούς από προσαρτήσεις. Το ολοκληρωμένο σύστημα μέτρησης και αποτύπωσης συμπερασμάτων είναι βασισμένο σε μοντελοποίηση συμπεριφορών αλλαγής του καρδιακού παλμού και της ειδικής διηλεκτρικής αγωγιμότητας του δέρματος σε πραγματικό χρόνο. Η συσκευή χρησιμοποιεί οπτικούς και διηλεκτρικούς αισθητήρες επαφής και έχει μελετηθεί σε αντιπαραβολή με διαβαθμισμένα περιβάλλοντα προκλητών καταστάσεων νοητικής φόρτισης. Σειρές πειραματικών διαδικασιών εφαρμοσμένες σε διαβαθμισμένα σενάρια πρόκλησης ψυχοσωματικών διεγέρσεων έχουν ολοκληρωθεί για επικύρωση, μελέτη επιδόσεων και λειτουργία του συστήματος ακόμη και σε σύγκριση με εμπορικό προϊόν. Πειραματικά αποτελέσματα δείχνουν αξιόλογους συσχετισμούς του μοντέλου και των επιδόσεων του συστήματος με τις αναμενόμενες αποκρίσεις με ενθαρρυντικά ποσοστά ακρίβειας.