bluuebunny/crossref_metadata_2025 huggingface dataset:
Interleukin-1ß / Interleukin (IL)-1-Receptor-Antagonist (IL1-RA) Axis in Invasive Bladder Cancer – An Exploratory Analysis of Clinical and Tumor Biological Significance
Authors: Vukevic Marko , Chamlati Jorge M , Hennenlotter Jörg , Todenhöfer Tilman , Lütfrenk Thomas , Jersinovic Sebastian , Tsaur Igor , Stenzl Arnulf , Rausch¹ Steffen
Published: January 2024

Background: Previous data indicate a role of IL-1 and IL-1RA imbalance in bladder carcinoma (BC) and inhibition of IL-1 signaling might be considered a treatment option. Objective: To assess expression patterns and the prognostic role of IL-1ß and IL-1RA in invasive BC and to evaluate their interaction with AKT signaling and proliferation. Design, Setting, and Participants: The study included two independent cohorts of n=92 and n=102 patients who underwent radical cystectomy for BC. Specimen from BC and benign urothelium (n=22 and n=39) were processed to a tissue microarray and immunohistochemically stained for IL-1ß, IL-1RA, AKT and Ki-67. Expression scores were correlated to clinical variables and Ki-67 and AKT expression. Outcome measurements and statistical analysis: Association with outcome was assessed using Wilcoxon Kruskal-Wallis tests, Chi-square tests or linear regression, dependent on the variable’s category. Kaplan–Meier and Cox proportional hazard analyses were used to estimate recurrence-free (RFS), cancer-specific (CSS) and overall survival (OS). Results: Both, IL-1ß and IL-1RA were significantly overexpressed in invasive BC compared to benign urothelium in both cohorts (p<0.005). IL-1ß was associated with vascular invasion (210 vs. 183, p<0.02), lymphatic invasion (210 vs. 180, <0.05) and G3 cancer (192 vs. 188, <0.04). Survival analysis revealed favorable RFS, CSS, and OS in case of high IL-1ß expression (p<0.02, <0.03 and <0.006, respectively). Multivariate analyses revealed an independent impact of (low) IL1ß expression on RFS, CSS and OS. IL-1ß and IL-1ß/IL-1RA ratio were positively correlated to AKT expression (p<0.05 and <0.01, respectively). Additionally, high expression of Ki-67 (>15%) correlated with higher levels of IL-1β (p=0.01). Conclusions: Overexpression of IL-1ß and IL-1RA is frequently found in BC, with a prognostic significance observed for IL-1ß protein expression. The observed link between the IL-1ß / IL-1RA axis and AKT signaling may indicate possible autophagy activation processes beside the known tumor-promoting effects of AKT.
Perspectives on Microbiome Therapeutics in Infectious Diseases: A Comprehensive Approach beyond Immunology and Microbiology
Authors: Seo Hoonhee , Song Ho-Yeon
Published: January 2024

Although global life expectancy has increased over the past 20 years due to improvements in managing infectious diseases, one in five people still succumbs to infections. Humanity is tirelessly working towards developing vaccines and antimicrobial agents in response to this ongoing threat. However, pathogens continue to acquire numerous resistance mechanisms and proliferate. Meanwhile, the COVID-19 pandemic has prompted us to recognize that focusing solely on the killing strategies of immunology and microbiology in complex and multisystemic infectious diseases is insufficient for understanding survival. In essence, there is a need for a treatment approach centered on disease tolerance, capable of alleviating pathology and/or promoting physiological functions in conjunction with the existing strategies of host immune response and pathogen destruction. Against this backdrop, this narrative review comprehends and introduces microbiome therapeutics, which recently garnered attention as next-generation treatments regarding two defense strategies against infectious diseases. First, we delineate the application of existing probiotics and then the microbiome in infectious diseases. Subsequently, we expand this concept to encompass host microbiome crosstalk and present related microbiome therapeutics' current status and direction. Ultimately, the review presents a fresh perspective on understanding microbiome therapeutics in infectious diseases based on a cooperative defense system.
Data Reuse in Agricultural Genomics Research: Present Challenges and Future Solutions
Authors: Hafner Alenka , DeLeo Victoria , Deng Cecilia , Elsik Christine G. , Fleming Damarius , Harrison Peter W. , Kalbfleisch Theodore S. , Petry Bruna , Pucker Boas , Quezada-Rodríguez Elsa H. , Tuggle Christopher K. , Koltes James
Published: January 2024

The scientific community has long benefited from the opportunities provided by data reuse. Recognizing the need to identify the challenges and bottlenecks to reuse in the agricultural research community and propose solutions for them, the data reuse working group was started within the AgBioData consortium (https://www.agbiodata.org/) framework. Here, we identify the limitations of data standards, metadata deficiencies, data interoperability, data ownership, data availability, user skill level, resource availability, and equity issues, with a specific focus on agricultural genomics research. We propose possible solutions stakeholders could implement to mitigate and overcome these challenges and provide an optimistic perspective on the future of genomics and transcriptomics data reuse.
Influence of Applied Loads on Free Vibrations of Functionally Graded Material Plate-Shell Panels
Authors: Moita José Simões , Franco Correia Victor , Mota Soares Cristóvão
Published: January 2024

The influence of applied loads on free vibrations analysis of plates and shells panels made of functionally graded materials is analyzed in the present work. Formulations for the static analysis considering geometrically nonlinear behavior, as well as linear buckling and free vibrations analyses are considered. The calculation of the through-thickness stress distribution is also performed. A finite element model based on a higher order shear deformation theory and using a non-conforming triangular flat plate/shell element with 3 nodes, and 8 degrees of freedom per node is used in the numerical implementation. The results obtained with this numerical model are presented, discussed, and compared with alternative solutions published by other authors in some benchmark applications.
Evaluation of Tomato Germplasm against Tomato Brown Rugose Fruit Virus and Identification of Resistance in Solanum pimpinellifolium
Authors: Jaiswal Namrata , Chanda Bidisha , Gilliard Andrea , Shi Ainong , Ling Kai-Shu
Published: January 2024

Tomato is one of the most important vegetable crops grown worldwide. Tomato brown rugose fruit virus (ToBRFV), a seed-borne tobamovirus, poses a serious threat to tomato productions due to its ability to break the resistant genes (Tm-1, Tm-2, Tm-22) in tomato. The objective of this work was to identify new resistance source(s) of tomato germplasm against ToBRFV. To achieve this aim, a total of 476 accessions from 12 Solanum species were tested with the ToBRFV US isolate for their resistance and susceptibility. As a result, a total of 44 asymptomatic accessions were identified as resistance/tolerance, including 31 accessions of S. pimpinellifolium, one accession of S. corneliomulleri, four accessions of S. habrochaites, three accessions of S. peruvianum and five accessions of S. subsection lycopersicon hybrid. Further analysis using serological tests identified four highly resistant S. pimpinellifolium lines, PI 390713, PI 390714, PI 390716 and PI 390717. The inheritance of resistance in the selected lines was verified in next generation and confirmed by RT-qPCR. To our knowledge, this is a first report of high resistance to ToBRFV in S. pimpinellifolium. These new genetic resources will expand the genetic pool available for breeders to develop new resistant cultivars of tomato against ToBRFV.
Understanding the Ge@GeO2-C Composite Anode via a Simple High-Energy Ball-Milling Process for Li-Ion Batteries
Authors: Han Jinhyup , Kim Hyun Woo
Published: January 2024

To address the limitations of the current anodes of Li+-ion batteries (LIBs), a Ge/GeO2/Carbon (Ge@GeO2-C) composite was designed by introducing a high-energy ball-milling process for advanced LIBs. Ge@GeO2-C is prepared and characterized by XPS, XRD, SEM, and TEM, which facilitate synthesis and provide controllability with respect to milling time. Interestingly, as the ball-milling time increased, the proportion of metallic Ge increased during the carbon thermal reduction reaction. The electrochemical characteristics of Ge@GeO2-C are assessed using differential capacity analysis (dQ/dV) and galvanostatic charge-discharge techniques to confirm its viability as an anode material in LIBs. The results demonstrated decent initial and secondary capacities of approximately 1800 mAh g-1 (for the first cycle) and 838 mAh g-1 (for the second cycle) at a rate of C/60 by the reaction between Ge and the Li-Ge complex. Furthermore, postmortem characterization was performed to gain an understanding of the material, suggesting future prospects for advanced LIBs.
New and Emerging Biological and Oral/Topical Small-Molecule Treatments for Psoriasis
Authors: Carmona-Rocha Elena , Rusiñol Lluís , Puig Lluís
Published: January 2024

The introduction of biologic therapies has led to dramatic improvements in the management of moderate-to-severe psoriasis. Even though the efficacy and safety of the newer biologic agents are difficult to match, oral administration is considered an important advantage by many patients. Current research is focused on development of oral therapies with improved efficacy and safety compared to available alternatives, as exemplified by deucravacitinib, the first oral allosteric Tyk2 inhibitor approved for the treatment of moderate-to-severe psoriasis in adults. Recent advances in our knowledge of psoriasis pathogenesis have also led to the development of targeted topical molecules, mostly focused on intracellular signaling pathways, such as AhR, PDE-4 and Jak-STAT. Topical tapinarof, an AhR modulator, and roflumilast, a PDE-4 inhibitor, have exhibited favorable efficacy and safety outcomes have been approved by the FDA for the topical treatment of plaque psoriasis. This revision focuses on the most recent oral and topical therapies available for psoriasis and specially on those that are currently under evaluation and development for the treatment of psoriasis.
Flavonoids As CYP3A4 Inhibitors In Vitro
Authors: Kondža Martin , Brizić Ivica , Jokić Stela
Published: January 2024

Flavonoids, a diverse group of polyphenolic compounds found abundantly in fruits, vegetables, and beverages like tea and wine, offer a plethora of health benefits. However, their potential interaction with drug metabolism, particularly through inhibition of the cytochrome P450 3A4 enzyme, the most versatile and abundant enzyme in the liver. CYP3A4 is responsible for metabolizing approximately 50% of clinically prescribed drugs across diverse therapeutic classes, so these interactions have raised concerns about potential adverse effects. This review delves into the scientific evidence surrounding flavonoid-mediated CYP3A4 inhibition, exploring the inhibitory potential of investigated flavonoids and future implications. Kusehnol I, chrysin, leachianone A and sophoraflavone G showed the largest inhibitory potentials and lowest IC50 values. While the clinical significance of flavonoid-mediated CYP3A4 inhibition in dietary contexts is generally considered low due to moderate intake and complex interactions, it poses a potential concern for individuals consuming high doses of flavonoid supplements or concurrently taking medications metabolized by CYP3A4. This can lead to increased drug exposure, potentially triggering adverse reactions or reduced efficacy.
Methyl-Jasmonate Functions as a Molecular Switch Promoting Cross-Talk between Pathways for the Biosynthesis of Isoprenoid Backbones Used to Modify Proteins in Plants
Authors: Chevalier Quentin , Huchelmann Alexandre , Debié Pauline , Mercier Pierre , Hartmann Michael , Vonthron-Sénécheau Catherine , Bach Thomas J. , Schaller Hubert , Hemmerlin Andréa
Published: January 2024

The modification of GFP-CaaL sensor proteins by geranylgeranyl groups in plants requires an active plastidial mevalonate (MVA)-independent pathway. As a consequence, fosmidomycin, a specific inhibitor of 1-deoxy-D-xylulose (DX)-5 phosphate reductoisomerase/DXR, the second enzyme in this so-called methylerythritol phosphate (MEP) pathway, impedes protein prenylation, which results in GFP-labeling of nuclei instead of the plasma membrane. In tobacco cells, a visual screen of conditions that allowed membrane localization of GFP-CaaL proteins in the presence of fosmidomycin, pinpointed jasmonic acid methyl esther (Me-JA) as a chemical able to overcome the inhibition in a gradual manner. Using Arabidopsis protein prenyltransferase loss-of-function mutant lines expressing GFP-CaaL proteins, we demonstrated that Me-JA induces a modification in protein substrate recognition by protein farnesyltransferase (PFT). Similar to Me-JA, farnesol and MVA also alter the protein substrate specificity of PFT, whereas DX and geranylgeraniol have limited or no effect. Our data indicate that stimulation of the MVA pathway adjusts the protein substrate specificity of PFT, which is corroborated with metabolic cross-talk of the origin of the prenyl group used to modify the protein. To illustrate how activation of the MVA pathway impacting PFT substrate specificity benefits a plant under stress conditions, a model is proposed.
Antecedent Factors Behavioral Intentions to Use Traffic Accident Claim System
Authors: Sutrisno Aristianto Budi , Aldhi Ian Firstian , Suhariadi Fendy , Wijoyo Suparto , Teofilus Teofilus , Cahyadi Eri , Ikhsan Ikhsan , Hardaningtyas Dwi , Abbas Ansar
Published: January 2024

This research article aims to examine the factors that influence behavioral intentions using the traffic accident claim system in Indonesia. This research uses the Theory of Planned Behavior, the Model of Technology Acceptance, and the Integrated Theory of Technology Acceptance and Use, as well as using the Structural Equation Modeling-Partial Least Squares. The questionnaire was distributed to 580 respondents from three institutions – police, hospitals, and state-owned insurance companies – using quota sampling techniques. The results showed that TPB, TAM, and UTAUT had a significant influence in encouraging behavioral intentions using the traffic accident claim system. Further, the study found that 21st-century digital skills have a moderate role in the impact of acceptance models, planned behavior, and technology use on behavioral intent. Although the study was conducted in Indonesia and is limited to three institutions, it provides strategic guidance for policymakers to improve the use of traffic accident claim systems and reduce Road Traffic Accidents. Further research is recommended to explore from different angles and focus on service providers/operators of traffic accident claim systems to refine the findings of this study. This study contributes to the literature by investigating the factors that influence behavioral intentions using traffic accident claim systems and has a high degree of accuracy of answers from the point of view of traffic safety officers.
Special Relativity in Terms of Hyperbolic Functions with Coupled Parameters in 3+1 Dimensions
Authors: Akintsov Nikolai S. , Nevecheria Artem P. , Kopytov Gennadii F. , Yang Yongjie
Published: January 2024

This paper presents a new method for parameterizing the Lorentz group based on coupled parameters. From the Euler–Hamilton equations, an additional angular rapidity and perpendicular rapidity are obtained, and the Hamiltonian and Lagrangian of a relativistic particle are expanded into rapidity spectra. A so-called passage to the limit is introduced that makes it possible to decompose physical quantities into spectra in terms of elementary functions when explicit decomposition is difficult. New rapidity-dependent Lorentz-invariant coordinates are obtained, and the descriptions of particle motion using the old and new Lorentz-invariant forms as applied to plane waves are compared. Based on a classical model of particle motion in the field of a plane monochromatic electromagnetic wave and in that of a plane laser pulse, the rapidity-dependent spectral decompositions into elementary functions are presented, and the Euler–Hamilton equations are derived as rapidity functions in 3+1 dimensions.
High Temperature Creep and Microstructure Evolution of Alloy 800H Weldments with Inconel 625 and Haynes 230 Filler Materials
Authors: Li Wenjing , Xiao Lin , Walters Lori , Dong Qingshan , Ienzi Maurizio , Sloan Robyn
Published: January 2024

Alloy 800H stands as one of the few code qualified materials for fabricating in core and out of core components operating in high temperature reactors (HTRs). Welding is a common practice for assembling these components, however, the election of a suitable filler material is essential to enhance the high-temperature creep resistance of Alloy 800H weldments in high temperature applications. In this study, Inconel 625 and Haynes 230 filler material were used to weld the Alloy 800H plates employing the Gas Tungsten Arc Welding (GTAW) technique. The high temperature tensile, creep rupture property, microstructural stability and evolution of the weldments after high temperature exposure were investigated and compared with Alloy 800H. The results showed that the both weldments exhibited enhanced tensile and creep behavior at 760 oC. The creep rupture time of the weldments with Inconel 625 filler and Haynes 230 filler materials was about two and three time longer than that of Alloy 800H base metal when tested at 80 MPa and 760 oC, respectively. Carbides (MC and M23C6) were commonly observed in the microstructure of both the weld and base metals in the two weldments after high temperature creep tests. However, the Inconel 625 filler weldment displayed detrimental δ and Laves phase in the fusion zone and these precipitates could be potential sites for initiating cracks following prolonged high temperature exposure. The study showed that the weldment with Haynes 230 exhibited better phase stability and creep rupture property than the one with Inconel 625 filler material, suggesting its potential as a candidate filler material for Alloy 800H for further investigation. The finding also emphasizes the critical consideration of microstructural evolutions and phase stability in evaluating high temperature materials and their weldments in high temperature reactor applications.
Effect of Pomegranate (Punica granatum) Peel Extract Powder on the Gross Consistency of Stool in Large Ruminates
Authors: Ansari Abdur Rahman , Shah Danish Mumtaz Hussain , Mohy-ud-din Imran , Saqlain Muhammad
Published: January 2024

Punica granatum (PG) or Pomegranate is a bush, having many trunks and often get taller 1.8 to 4.7m long and their leaves are shiny and fleshy, approximately 7 to 8cm in length. Traditionally, it is used in diarrhea and dysentery due to its strong constricting property. Punica Granatum covering used in dysentery, diarrhea, piles, bronchitis. It is also used to minimize the risk of heart disease. The peel extract of Punica Granatum contain methanol and their dried peels has antidiarrheal venture, also help in wound healing activity. Peels of the pomegranate also holds around 60% of the fruit and they contain different types of ingredients including ellagitannins and proanthocyanidin compounds and minerals such as calcium, phosphorus, magnesium, potassium, flavonoids and sodium. Some animals were found in different local areas with both acute and chronic diarrhea. The condition of these animals were quite miserable because of dehydration and loss of electrolytes in the body cells of the animals. They were unable to move due to seriousness of the disease. 8 grams of PG Peel Powder mixed with 1 liter of water, 2 g of PG Peel Powder mixed with 250 ml water and 8 g of PG Peel Powder mixed with 1 liter of water were administrated orally by using sterilized bottles to the selected three cases. 3 days after the administration of different doses, all cases of diarrheal animals show a significant recovery. The condition of the animals seem to be healthier. Before administration of the pomegranate peel powder extract, all three cases had weak body structure due to diarrhea. Watery stool that may be yellow in color and mucus was also evident in the stool, due to this reason the patient calf was weak and depressed. In sometimes they also show unconsciousness and blood glucose levels seem to be reduced from the normal level.
The Interactive Impacts of Corn Particle Size and Conditioning Temperature on Performance, Carcass Traits, and Intestinal Morphology of Broiler Chickens
Authors: Ghasemi-Aghgonbad Asadollah , Olyayee Majid , Janmohammadi Hossin , Abdollahi M. Reza , Kianfar Ruhollah
Published: January 2024

This study aimed to investigate the interactions between corn particle size (PS) and conditioning temperature (CT) on the performance, carcass traits, intestinal morphology, and immune responses in broilers fed a corn-soybean meal-based diet. A total of 360, one-day-old male broiler chicks (Ross 308) were randomly allocated into six dietary treatments in a 2×3 factorial arrangement, consisting of two corn PS (finely ground with geometric mean diameter (GMD) of 357 µm (PSF) vs. coarsely ground corn with GMD of 737 µm (PSC), and three CT [unconditioned (CTU), conditioned at 75◦C (CT75) and 90◦C (CT90)]. Birds accommodated in 30 pens with five replicates and 12 chicks per each. There was no interaction between corn PS and CT on growth performance and immune response of broilers at any growth phases. However, during the starter (0-10d) period, the average daily weight gain (ADWG) and feed conversion ratio (FCR) of PSF-fed birds were significantly improved compared to those fed PSC (P<0.05). During the starter (0-10d) and grower (11-24d) periods, increasing the conditioning temperature of corn increased the ADWG, while in the starter phase only the CT75 caused a lower FCR (P<0.05). Broilers fed PSF corn showed lowest FCR during the finisher (25-42d) period compared to those fed PSC (P<0.05). Conditioning corn at 75ºC reduced FCR during the finisher (25-42d) period compared to the birds fed CTU and CT90 corn (P<0.05). In whole experimental periods (1-42d), PSF and CT75 treatment increased the ADWG compared to the PSC and CTU (P<0.05). The CT75 treatment improved primary total anti-sheep red blood cell (SRBCs) titer (IgT) and IgM and secondary IgT and IgG responses compared to the other experimental groups (CTU and CT90) (P<0.05). No significant PS × CT interaction was found on Newcastle disease (ND) antibody titer of broiler chickens (P>0.05). Feeding CT75 corn reduced duodenum and jejunum relative length compared to the birds fed diets containing CTU corn. Significant PS×CT interactions (P<0.05) were observed for villus height, villus height to crypt depth, crypt depth, muscle thickness, and absorption surface area of jejunum. The highest carcass yield observed in PSF-CT75-group (P<0.05). In conclusion, the use of finely ground corn (PSF) conditioned at 75℃ (CT75) was beneficial to growth performance, development of the digestive tract, jejunum histomorphometry and the immune responses of broilers.
Molecular genomic analyses of Enterococcus cecorum from sepsis outbreaks in broilers
Authors: Rhoads Douglas D , Pummill Jeff , Alrubaye Adnan Ali Khalaf
Published: January 2024

Extensive genomic analyses of Enterococcus cecorum isolates from sepsis outbreaks in broilers suggests a polyphyletic origin likely arising from core genome mutations rather than gene acquisition. This species is normal intestinal flora in avian species with particular isolates associated with osteomyelitis. More recently, the species has been associated with sepsis outbreaks affecting broilers during the first 3 weeks post hatch. Understanding the genetic and management basis of this new phenotype is critical for developing strategies to mitigate this emerging problem. Phylogenomic analyses of 227 genomes suggest that sepsis isolates are polyphyletic and closely related to both commensal and osteomyelitis isolate genomes. Pangenome analyses detect no gene acquisitions that distinguish all sepsis isolates. Core genome SNP analyses identify a number of mutations, affecting protein coding sequence, that are enriched in sepsis isolates. Analysis of the protein substitutions supports mutational origins of sepsis isolates.
Nonlocal Boundary Problem for a Loaded Equation of Mixed Type in a Special Domain
Authors: Bozor Islomov , Oybek Yunusov , Akmaljon Abdullaev
Published: January 2024

The purpose of the research is to investigate the unique solvability of a nonlocal boundary value problem for a loaded equation of parabolic-hyperbolic type in a special domain. Methods: Using representations of a general regular solution, the existence and uniqueness of the problem posed is proved. Results: A new method for proving the unique solvability of nonlocal boundary value problems for one loaded equation of mixed type in a special domain has been formed and developed. Conclusions: The obtained results make it possible to solve some problems of genetics, immunology, transonic gas dynamics and thermal physics, which are associated with displacement.
Impact of Various Types of Heat Processing on the Selenium Content of Goose Breast Meat
Authors: Goluch Zuzanna , Bąkowska Małgorzata , Haraf Gabriela , Pilarczyk Bogumiła
Published: January 2024

The purpose of this study was to 1) examine the impact of various types of heat processing used by consumers (water bath cooking WBC, oven convection roasting OCR, grilling G, pan frying PF) on the selenium content and its retention in goose breast meat (with and without skin); 2) Estimation of coverage of this element's daily requirement in adults after consuming 100 g of goose breast meat. The material used in the study comprised 36 breast muscles cut from carcasses of 17-week-old White Koluda geese. The moisture, ash, and selenium were determined in both raw and thermally processed muscles. It has been concluded that various methods of heat processing significantly impact cooking loss, moisture, ash and selenium content of meat. The heat processing increased the selenium content of the muscle regardless of the presence of skin, which affects the possibility of covering adults' Nutrient Reference Values-Requirements (NRV-R) for this element in the range of 33.3-44.8%. Goose breast meat can be a valuable component of a diversified diet. It provides many nutrients. It is also a safe source of selenium. It is unlikely that adult consumers, even those who eat goose regularly, will exceed this element's upper tolerable intake level.
EMG-Based Biomechanical Cybernetic Control of an Avatar Robotic Fish
Authors: Montoya Manuel A. , Torres-Cordoba Rafael , Magid Evgeni , Martínez-García Edgar Alonso
Published: January 2024

This study introduces a cybernetic control and architectural framework for a robotic fish avatar operated by a human. The behavior of the robot fish is influenced by the electromyographic (EMG) signals of the human operator, triggered by stimuli from the surrounding objects and scenery. An deep artificial neural network (ANN) with perceptrons classifies EMG signals, discerning the type of muscular stimuli generated. The research unveils a fuzzy-based oscillation patterns generator (OPG) designed to emulate functions akin to a neural central pattern generator, producing coordinated fish undulations. The OPG generates swimming behavior as an oscillation function, decoupled into coordinated step signals, right and left, for a dual electromagnetic oscillator in the fish propulsion system. Furthermore, the research presents an underactuated biorobotic mechanism of the subcarangiform type, comprising a two-solenoid electromagnetic oscillator, an antagonistic musculoskeletal elastic system of tendons, and a multi-link caudal spine composed of helical springs. The biomechanics dynamic model and control for swimming, as well as the ballasting system for submersion and buoyancy, are deduced. Experimental results encompass EMG pattern recognition, OPG, and coordinated fish locomotion, with additional topics illustrated through numerical simulations.
Unleashing Elastic-Plastic Response by Study of Simulated Nanoindentation P-h Plots
Authors: Praveen Kumar Ramagiri , BHATTACHARYYA Arnab
Published: January 2024

Nanoindentation load-depth (P-h) plots is the basis for determination of mechanical properties of the samples and is especially vital for thin coatings deposited on substrates of various mechanical makeup from amorphous-brittle (borosilicate glass) to Silicon (having different crystallographic texture) to ductile substrates like stainless steel as well other aspects like indenter tip shape. The elastic-plastic response by simulated P-h plots as per modified empirical relations have been presented. The outcomes of this computational studies enlighten the database on the P-h plots for various coating/substrate systems and shall aid in the analysis of experimental P-h plots obtained,
The Power of Partnership: NYCEAL Collaborations With Health Agencies and Mobile Vaccination Vans
Authors: Larson Rita , Hussain Sarah , Chau Michelle M. , Jones Andrew , Vangeepuram Nita , Madden Devin , Berhane Timnit , Shuman Saskia , Islam Nadia , Trinh-Shevrin Chau
Published: January 2024

New York City experienced a high COVID-19 burden and striking disparities among racial and ethnic minoritized groups. The New York Community Engagement Alliance Against COVID-19 Disparities (NYCEAL) collaborated with health agencies and clinical providers to increase and facilitate COVID-19 vaccinations across New York City. NYCEAL partners and their network of hundreds of community health workers delivered vaccine education, fostered community trust, and supported vaccine uptake among low-income, limited‒English-proficient, and racial and ethnic minoritized communities. With funding from the National Institutes of Health (NIH), the objective of NYCEAL was to reduce COVID-19 disparities by increasing vaccine uptake and promoting trust in science. (Am J Public Health. 2024;114(S1):S92–S95. https://doi.org/10.2105/AJPH.2023.307455 )
Rapid Community Translation in the Colorado CEAL (CO-CEAL) Program: Transcreating Messaging to Promote COVID-19 Vaccination
Authors: Brewer Sarah E. , Fisher Mary , Zittleman Linda , Warman Meredith K. , Fort Meredith , Gilchrist Emma , Mallory Jameel , Mullen Rebecca , Barron Jose , Skenadore Amanda , Ahmed Farduus Y. , LoudHawk-Hedgepeth Crystal , Tamez Montelle , Kwan Bethany M. , Nease Donald E.
Published: January 2024

Providing communities with COVID-19 vaccination information is essential for optimizing equitable vaccine uptake. Using rapid community translation, adapted from Boot Camp Translation, five community teams transcreated COVID-19 vaccination campaigns. Transcreated messaging incorporated community attitudes, culture, and experiences. Using rapid community translation for the promotion of COVID-19 vaccination demonstrates a successful approach to engaging communities most affected by the pandemic to develop messages that reflect community values, assets, and needs, especially when time is of the essence. (Am J Public Health. 2024;114(S1):S50–S54. https://doi.org/10.2105/AJPH.2023.307456 )
Partnering With Community Health Workers to Address COVID-19 Health Inequities: Experiences of the California Alliance Against COVID-19
Authors: Rodriguez Espinosa Patricia , Vázquez Evelyn , AuYoung Mona , Zaldivar Frank , Cheney Ann Marie , Sorkin Dara , Zender Robynn , Corchado Claudia G. , Burke Nancy J.
Published: January 2024

With funding from the National Institutes of Health’s Community Engagement Alliance, starting in fall 2020, 11 academic medical centers and 75 community partners came together as the California Alliance Against COVID-19 to address COVID-19 inequities in California. Using data from focus groups, statewide meetings, and a statewide partner survey, we describe how promotoras and community health workers (P/CHWs; n = 540) helped to promote access to COVID-19 information, testing, and vaccination. We highlight opportunities to promote health equity among other public health collaborators with a P/CHW model. (Am J Public Health. 2024;114(S1):S45–S49. https://doi.org/10.2105/AJPH.2023.307471 )
Rare Median Nerve and Digital Nerve Tumor Resection and Distal Nerve Transfers
Authors: El-Haj Madi , Eliav Tal , Vorobeitchik Sofia A. , Yusef Azraq , Fellig Yakov , Safran Ori
Published: January 2024

Cases:

We present 2 cases of median nerve reconstruction using distal nerve transfers after resection of unusual benign median nerve tumors. Critical sensation was restored in case 1 by transferring the fourth common digital nerve to first web digital nerves. Thumb opposition was regained by transferring the abductor digiti minimi ulnar motor nerve branch to the recurrent median motor nerve branch. Critical sensation was restored in case 2 by transferring the long finger ulnar digital nerve to the index finger radial digital nerve.

Conclusion:

Distal nerve transfers, even with short grafts, are reliable median nerve deficit treatments, sparing the need for larger autologous nerve grafts and late tendon opponensplasties.
Distal Femoral Osteotomy for the Management of Coronal Deformity Following Total Knee Arthroplasty
Authors: Reif Taylor J. , Greenstein Michael D. , Greenberg Michael , Rozbruch S. Robert
Published: January 2024

Case:

We present 2 cases demonstrating the management of coronal malalignment with an existing total knee arthroplasty using opening wedge distal femur osteotomy. The mechanical axis was corrected, and the primary total knee implants were maintained. Patients resumed full activity 3 to 4 months after surgery.

Conclusion:

In certain cases, opening wedge distal femoral osteotomy is an option to correct coronal malalignment with an existing total knee arthroplasty without revising the implant.
En Bloc Excision and Bone Grafting for Monostotic Multiple Intraosseous Glomus Tumors of the Distal Phalanx
Authors: Joyson DR Kathir , Prabhu Anne Jennifer , Pallapati Samuel C. Raj
Published: January 2024

Case:

Glomus tumors of the hand are rare tumors that occur predominantly in the subungual region. Though multicentric glomus tumors have been reported in the subungual region involving the nailbed, monostotic multiple intraosseous glomus tumors have not been reported so far. We report a case of a 36 year-old woman who presented with a 5-year history of intermittent thumb pain, aggravated with exposure to cold or pressure. A glomus tumor of the thumb was excised, but symptoms returned 3 months later. She ultimately underwent curettage with bone grafting of a recurrent glomus tumor at the same site, and has been free of symptoms for 1.5 years.

Conclusion:

Intraosseous glomus tumors may present as multiple synchronous lesions. This, to the best of our knowledge, is the first case report of monostotic multiple intraosseous glomus tumors.
Fatty Degeneration of the Rotator Cuff Muscles Improves in Shoulders with Successful Arthroscopic Rotator Cuff Repair
Authors: Matsuki Keisuke , Sugaya Hiroyuki , Takahashi Norimasa , Tokai Morihito , Hoshika Shota , Ueda Yusuke
Published: January 2024

Background:

There remain arguments regarding whether fatty degeneration of the rotator cuff muscles improves following rotator cuff repair. The purpose of this study was to prospectively investigate changes in fatty degeneration of the rotator cuff muscles, quantitatively measured on magnetic resonance imaging (MRI) with use of transverse relaxation time (T2) mapping techniques, and to assess the relationship between these changes and clinical outcomes.

Methods:

Patients were included if they were scheduled for arthroscopic rotator cuff repair using the suture-bridge technique between June 2014 and December 2015, underwent preoperative MRI including the T2 mapping sequence, and consented to participate in the study. Exclusion criteria consisted of trauma within 2 months before preoperative MRI, isolated subscapularis tears, patch augmentation, neuromuscular disease, and a follow-up duration of <2 years. MRI scans were acquired preoperatively and at 2 years postoperatively, and T2 values of the supraspinatus and infraspinatus muscles were measured, with smaller T2 values indicating less fat content. Shoulders were evaluated on the basis of active range of motion (ROM), Constant and University of California Los Angeles Shoulder Rating Scale scores, shoulder external rotation strength with the arm at the side, and rotator cuff integrity on postoperative MRI.

Results:

A total of 103 patients (103 shoulders) with a mean age of 65 ± 9 years (range, 42 to 83 years) were included, of whom 52 were male and 51 were female. There were 13 partial, 18 small, 35 medium, 33 large, and 4 massive tears. Concomitant subscapularis tears were observed in 35 shoulders. Overall, ROM, clinical scores, and external rotation strength significantly improved postoperatively. Retears were found in 27 shoulders (26%). External rotation strength significantly improved postoperatively only in shoulders without a retear. Among shoulders without a retear, the postoperative T2 values of the supraspinatus and infraspinatus were significantly smaller than the preoperative values (p < 0.001 for both); however, no improvement was seen in shoulders with a retear.

Conclusions:

Shoulders with successful repair demonstrated significantly smaller T2 values postoperatively as well as significantly improved external rotation strength. Fatty degeneration of the cuff muscles can be reversed, at least in part, and muscle strength improves in shoulders with successful repair.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Functional and Radiographic Outcomes of Open Proximal Femoral Fractures Caused by Gunshot Wounds in Yemen
Authors: Hutaif Mohammad , Al-Moaish Abdullah , Al-fadliy Anwar
Published: January 2024

Background:

Open proximal femoral fractures caused by gunshot wounds are rare but devastating injuries that pose considerable challenges for prognosis and management. The aim of this study was to evaluate the functional and radiographic outcomes of patients with open proximal femoral fractures caused by gunshot wounds treated at 3 Level-I trauma centers in Yemen and to identify the factors that influence them.

Methods:

We prospectively enrolled 174 patients with open proximal femoral fractures caused by gunshot wounds. The fractures were classified according to the Gustilo-Anderson and OTA/AO systems. The primary outcome measures were fracture union, infection, and functional outcomes. The secondary outcome measures were the Harris hip score (HHS) and the Short Form-36 (SF-36) health survey score. We performed multivariable logistic regression modeling to identify the predictors of complications and poor functional outcomes.

Results:

The overall rate of fracture union was 87%. The complication rates were 18% for infection, 13% for nonunion, 23% for reoperation, 12% for delayed union, 4% for osteonecrosis, 6% for heterotopic ossification, and 2% for amputation. The mean HHS at the final follow-up was 78.4, and the mean SF-36 score was 67.3.

Conclusions:

Open proximal femoral fractures caused by gunshot wounds are associated with high rates of complications and poor functional outcomes in Yemen. Early debridement, appropriate fixation, infection control, and adequate soft-tissue coverage are essential for achieving satisfactory results. The type of wound, the type of fracture, and the type of definitive fixation are significant predictors of the outcomes. Future studies should compare different fixation methods and evaluate the long-term outcomes and complications of these injuries.

Level of Evidence:

Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.
Gali Potensi Bumdes
Authors: Faizah Ima
Published: January 2024

Puji syukur kami panjatkan kehadirat Allah SWT karena dengan rahmat, karunia, dan hidayah-Nya kami dapat menyelesaikan Buku Pengabdian Kepada Masyarakat Universitas Muhammadiyah Sidoarjo di Desa Keboguyang tahun 2019 dengan baik dan lancar. Lokasi kegiatan Pengabdian Kepada Masyarakat berada di Desa Keboguyang, Kecamatan Jabon, Kabupaten Sidoarjo. Pada kegiatan ini, program kerja unggulan kami adalah penguatan ekonomi desa melalui BUMDes yang terdiri dari dua program (1) Pembuatan Pupuk Kompos Dari Kotoran Kambing,(2) Pengelolahan Budidaya Ikan Lele, dimana kegiatan tersebut kami laksanakan mulai tanggal 01 Agustus 2019 sampai dengan tanggal 06 Oktober 2019
Flexing as a Marketing Strategy: A Perspective from Islamic Economic Law
Authors: Sa'diyah Siti , Rizka Rizka , Rosyadi Imron
Published: January 2024

This research aims to analyze flexing in marketing from the perspective of Shariah economic law. The phenomenon of flexing, as a common marketing strategy, has recently become prevalent, particularly on social media. However, the current development of flexing presents several issues as it tends to disregard Shariah concepts, thereby potentially harming consumers. This study is a literature review that utilizes primary sources, such as interpretations by Yusuf Qardhawi and economist Reynal Kasali through YouTube channels, as well as secondary sources, including the phenomenon of flexing on social media. The findings of this research indicate that flexing can support marketing activities but tends to have negative impacts on society. Therefore, Islamic business practitioners are advised against employing flexing as a marketing tool, as it violates Shariah principles, such as avoiding defamation, arrogance, ostentation, extravagance, and hypocrisy.
An examination of multihazard marine transportation system (MTS) response and recovery operations during the 2020 hurricane season
Authors: Chambers Katherine , Murphy Joshua , Straub Jessamin , Enriquez Alejandra ,   U.S. Committee on the Marine Transportation System Resilience Integrated Action Team
Published: January 2024

The Committee on the Marine Transportation System (CMTS), Resilience Integrated Action Team (RIAT), was established in 2014 to foster the coordination and coproduction of knowledge that incorporates the concepts of resilience into the marine transportation system (MTS). The RIAT defines resilience as a four-phase cycle that incorporates preparation, response, recovery, and adaptation activities to minimize disruption to the MTS. The RIAT utilizes this definition of resilience to convene first-responder CMTS agencies to examine challenges and successes and make recommendations about past hurricane seasons. The 2020 hurricane season saw a record-breaking number of storms form in the Atlantic basin during a global pandemic. As a result, federal agencies were challenged to operate in a multihazard posture, and many former lessons learned needed to be adjusted to this unprecedented situation.
Efficacy of Growth Hormone in Chronic Kidney Disease
Authors:   3rd year BS.c. Nursing Student, School of Nursing, Galgotias University, Greater Noida 201306, Uttar Pradesh, India., ... Vishakha , Sinha Pragya ,   3rd year BS.c. Nursing Student, School of Nursing, Galgotias University, Greater Noida 201306, Uttar Pradesh, India., Sharma Bandhu ,   Tutor, School of Nursing, Galgotias University, Greater Noida 201306, Uttar Pradesh, India., Subashini S P ,   Dean, School of Nursing, Galgotias University, Greater Noida 201306, Uttar Pradesh, India.
Published: January 2024

Children with chronic kidney disease (CKD) have difficulty achieving normal growth due to severe alterations in the growth hormone (GH) and insulin-like growth factor (IGF-1) axis. Recombinant human growth hormone (rhGH) therapy (GH). It encourages long-term growth and allows children with CKD to reach normal height.It has been demonstrated to be both safe and effective. After a kidney transplant, growth retardation may remain. Multiple variables, such as steroid use, impaired renal function, and an aberrant GH axis, have contributed to this condition.
Role of Revised Baux Score in Burns
Authors:   Visiting Resident, Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India., Codandabany Naresh kumar , Chittoria Ravi Kumar ,   Professor, Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India., Singh Barath Kumar ,   Senior Resident, Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry 605006, India.
Published: January 2024

Burns is one of the risk factors contributing to the mortality and morbidity burden of developing countries. Even though advancements in burn patient management have significantly decreased the mortality. Predicting the outcome of severe burns patient at presentation plays a paramount role in guiding clinical judgment. Multiple scoring systems are available to predict mortality in burns patients in developed countries. In this article, the Revised Baux score has been applied in predicting mortality in burns patients.
Healthcare Research Applications in Meta-Analysis: A Review
Authors:   Ph.D scholar, Department of Community Medicine, Krishna Institute of Medical Sciences, Krishna Institute of Medical Sciences (Deemed to be University), Karad 415539, Maharashtra, India., Mane Dhiraj Kumar , Kakade Satish V ,   Associate Professor, Department of Community Medicine, Krishna Institute of Medical Sciences, Krishna Institute of Medical Sciences (Deemed to be University), Karad 415539, Maharashtra, India., Pawar Jayant ,   Research Scientist, Directorate of Research,  Department of Community Medicine, Krishna Institute of Medical Sciences, Krishna Institute of Medical Sciences (Deemed to be University), Karad 415539, Maharashtra, India.
Published: January 2024

Every new day comes up with different challenges in the healthcare sector in developing countries like ours. So this review article tells us the role of meta-analysis in current healthcare share and current health problems dealing with ‘Evidence-Based Medicine Practices’. This article is a combination of healthcare practices and meta-analysis in the field of medicine. Consideration of current trends and scenarios demonstrates a consistent increase in the use of meta-analysis, especially in randomized controlled trials and interventional studies. Meta-analyses look for new information in existing data. Comparing the results of meta-analyses with subsequent findings from large-scale, well-conducted, randomized controlled trials (so-called RCTs) is one way to assess the validity of this new knowledge. Such comparisons have yielded mixed findings thus far, with good agreement in the majority of cases but notable inconsistencies in others. One such exercise, for example, resulted in the publication of a paper titled "Lessons from a "successful, safe, simple intervention" that wasn't" misleading meta-analysis (use of metformin after diabetes mellitus). The inadequacies in meta-analyses that have been later challenged by data from RCTs can often be discovered with the benefit of hindsight. So this article directly or indirectly helps researchers to adopt new knowledge in Meta-analysis, especially for current healthcare practice. We can’t separate them as healthcare and meta-analysis both are two sides of the same coin.