bluuebunny/crossref_metadata_2025 huggingface dataset:
Interactive Clustered Heat Map Builder: An easy web-based tool for creating sophisticated clustered heat maps
Authors: Ryan Michael C. , Stucky Mark , Wakefield Chris , Melott James M. , Akbani Rehan , Weinstein John N. , Broom Bradley M.
Published: October 2019

Clustered heat maps are the most frequently used graphics for visualization and interpretation of genome-scale molecular profiling data in biology.  Construction of a heat map generally requires the assistance of a biostatistician or bioinformatics analyst capable of working in R or a similar programming language to transform the study data, perform hierarchical clustering, and generate the heat map.  Our web-based Interactive Heat Map Builder can be used by investigators with no bioinformatics experience to generate high-caliber, publication quality maps.  Preparation of the data and construction of a heat map is rarely a simple linear process.  Our tool allows a user to move back and forth iteratively through the various stages of map generation to try different options and approaches.  Finally, the heat map the builder creates is available in several forms, including an interactive Next-Generation Clustered Heat Map that can be explored dynamically to investigate the results more fully.
Continuous Storage Root Formation and Bulking in Sweetpotato
Authors: Bararyenya Astere , Tukamuhabwa Phinehas , Gibson Paul , Grüneberg Wolfgang , Ssali Reuben , Low Jan , Odong Thomas , Ochwo-Ssemakula Mildred , Talwana Herbert , Mwila Natasha , Mwanga Robert
Published: October 2019

This study investigated the phenotypic variation of continuous storage root formation and bulking (CSRFAB) growth patterns underlying the development of sweetpotato genotypes for identification of potential varieties adapted to piecemeal harvesting for small scale farmers. The research was conducted between September 2016 and August 2017 in Uganda. Genotypes from two distinct sweetpotato genepool populations (Population Uganda A and Population Uganda B) comprising 130 genotypes, previously separated using 31 simple sequence repeat (SSR) markers were used. Measurements (4 harvest times with 4 plants each) were repeated on genotypes in a randomized complete block design with 2 replications in 2 locations for 2 seasons. We developed a scoring scale of 1 to 9 and used it to compare growth changes between consecutive harvests. Data analysis was done using residual or restricted maximum likelihood (REML) in GenStat 18th Edition. There were strong linear and quadratic trends over time (P<0.001) indicating a non-linear growth pattern within and between locations, seasons, and genotypes for most traits. Some genotypes displayed early initiation and a determinate linear increase of bulking, while others showed late initiation following a quadratic growth pattern. Broad sense heritability of CSRFAB would be low due to large GxE interactions, however, it was relatively high (50.5%) compared to other yield related traits indicating high genetic influence and accuracy of the developed method to quantify yield overtime. A high level of reproducibility (89%) was observed comparing 2017A and 2017B seasons (A and B are first and second season, respectively) at the National Crops Resources Research Institute (NaCRRI), Namulonge, Uganda. Choosing CSRFAB genotypes can more than double the sweetpotato production (average maximum yield of 13.1 t/ha for discontinuous storage root formation and bulking (DSRFAB) versus 28.6 t/ha for CSRFAB demonstrating the importance of this underresearched component of storage root yield.
The use of indirect resin composite restorations in the management of localized anterior tooth wear: a clinical update part 2
Authors: Hansrani Virat Kumar , Laverty Dominic , Brunton Paul
Published: October 2019

This article will focus on the active management of localized anterior tooth wear using indirect resin composite restorations. Emphasis will be placed on minimally invasive methods of tooth preparation in order to preserve biological tooth tissue in an already compromised tooth structure. Active management commits the patient to considerable long-term maintenance and it is important, as with any treatment, that the advantages and disadvantages are fully explained to the patient.

CPD/Clinical Relevance: Numerous epidemiological studies have reported tooth wear to be increasing in incidence amongst the general population. This article aims to provide a methodical conservative approach in the management of the worn dentition.
Negligence and prescribing
Authors: Armstrong Amanda
Published: October 2019

This article will examine the concept of negligence; its elements, the civil laws surrounding it, and how to ensure defences against negligence claims. It will discuss the various legal cases that are used in establishing negligence, the role of the non-medical prescriber, and the possible pitfalls when prescribing. It will highlight the need to be aware of professional competencies that are necessary, especially when a role was previously undertaken by a doctor, as is the case with prescribing.
Learning from the Primary Care Home model
Authors: Hancock Dave
Published: October 2019

What messages for Primary Care Networks are there in a report by The King's Fund into Primary Care Homes? Dave Hancock finds out
One security solution does not fit all
Authors: Wray Andy
Published: October 2019

If you are looking for a new security system for your practice, or want to upgrade or extend your existing, it's difficult to know where to start. So what does this security company look like?
Can your practice staff also be your patients?
Authors: Pickering Sarah
Published: October 2019

Situations where a doctor is both an employer and the treating clinician of a patient are problematic and should be avoided. Sarah Pickering at Medical Protection looks at a recent query from the advice line
Dead wood profile of a semi-natural boreal forest - implications for sampling
Authors: Halme Panu , Purhonen Jenna , Marjakangas Emma-Liina , Komonen Atte , Juutilainen Katja , Abrego Nerea
Published: October 2019

Dead wood profile of a forest is a useful tool for describing forest characteristics and assessing forest disturbance history. Nevertheless, dead wood profiles, including both coarse and fine dead wood, are rare as well as studies on the effect of sampling intensity on the dead wood estimates. In a semi-natural boreal forest, we measured every dead wood item over 2 cm in diameter from 80 study plots. From eight plots, we further recorded dead wood items below 2 cm in diameter. Based on these data we constructed the full dead wood profile, i.e. the overall number of dead wood items and their distribution among different tree species, volumes of different size and decay stage categories. We discovered that while the number of small dead wood items was immense, their number dropped drastically from the diameter below 1 cm to diameters 2-3 cm. Different tree species had notably different abundance-diameter distribution patterns: spruce dead wood comprised mainly of the smallest diameter fractions, whereas aspen dead wood had larger share of large-diameter items. Considering volume, most dead wood was large (>10 cm in diameter), out of which 62% was birch. We also observed that the variation in the dead wood estimates was small for the numerically dominant tree species and smallest diameter categories, but high for the sub-dominant tree species and larger size categories. In conclusion, the more the focus of the dead wood inventory is on rare tree species and large dead wood items, the more comprehensive should the sampling be.
Рыбы озера Ара-Нур (Забайкальский край)
Authors: Gorlacheva E.P.
Published: October 2019

На основе ихтиологических исследований, проведенных на оз. Ара-Нур в 1998-1999 гг., приводится видовой список рыб. Ихтиофауна озера представлена 11 видами, относящимися к 7 семействам. Озеро, как и бассейн р. Хилок, характеризуется невысоким видовым разнообразием. В составе ихтиофауны преобладают рыбы бореально-равнинного комплекса. Наряду с озерными видами, в оз. Ара-Нур встречаются и речные виды, которые заходят сюда из р. Северная Горека. Большинство рыб являются бентофагами, хотя встречаются и ихтиофаги. По образу жизни большинство видов являются лимнофилами. Считаем, что озеро Ара-Нур имеет большое значение для нереста и зимовки рыб.
The effect of non-financial performance on financial performance moderated by information disclosure
Authors: Refmasari Veranda Aga , Supriyono R A
Published: October 2019

This research aimed to test the effect of non-financial performance on financial performance moderated by information disclosure. Balance scorecard was used to measure performance values in a comprehensive, coherent, measurable, and balanced. The research result showed that non-financial performance measures consisting of consumer, learning and growth perspectives affected financial performance, but internal business process did not affect financial performance. With cause-effect, learning and growth affect internal bussines process, and the internal business process affects customers Information openess does not has efffect of non-financial performance relationship towards financial performance. This research suggests that companies need to increase customer satisfaction and employee-based and strategic alignment growth to improve the company's financial performance.
Weighted Inequalities for Integral Operators with Almost Homogeneous Kernels
Authors: Urciuolo Marta
Published: October 2019

Let 𝑚 ∈ 𝑛 and 𝑎1, . . . , 𝑎𝑚 be real numbers such that for each 𝑖, 𝑎𝑖 ≠ 0 and 𝑎𝑖 ≠ 𝑎𝑗 if 𝑖 ≠ 𝑗. In this paper we study integral operators of the form

𝑇𝑓 (𝑥) = ∫ 𝑘1 (𝑥 – 𝑎1𝑦) . . . 𝑘𝑚 (𝑥 – 𝑎𝑚𝑦) 𝑓 (𝑦) 𝑑𝑦,

with .

If φ
𝑖,𝑗 satisfy certain uniform regularity conditions out of the origin, we obtain the boundedness of 𝑇 : 𝐿𝑝(𝑤) → 𝐿𝑝(𝑤) for all power weights 𝑤 in adequate Muckenhoupt classes.
On the Fourier Expansions of Eisenstein Series of Some Types
Authors: Kachakhidze Nikoloz
Published: October 2019

Bases of the spaces of Eisenstein series 𝐸𝑘(Γ0(4𝑁), χ) (𝑘 ∈ ℕ, 𝑘 ≥ 3, 𝑁 is an odd natural and square-free) and , ℕ is an odd natural and square-free) are constructed for any Dirichlet character mod 4𝑁 and Fourier expansions of these series are obtained.
Kenneth Waltz talks through Mark Rothko: Visual metaphors in the discipline of International Relations Theory
Authors: Güner Serdar Ş.
Published: October 2019

Semiotics constitutes an untapped and interdisciplinary source of enrichment for the discipline of International Relations (IR) theory. We propose two visual metaphors to that effect to interpret the figure depicting the central claim of structural realism (SR) offered by late Kenneth Waltz who is one of the most disputed, read, and inspiring IR theorists. The figure is the tenor of both metaphors. The vehicles are two paintings by Mark Rothko, namely, “Green and Tangerine on Red” and the “Number 14.” The metaphors generate innumerable meanings for the tenor and eliminate the criticism that SR is a static and an ahistorical theory. Thus, they benefit the Discipline characterised by academic cleavages on the meaning of theory, science, and production of knowledge.
Opening the Policy Window to Mobilize Action Against Corruption in the Health Sector Comment on "We Need to Talk About Corruption in Health Systems"
Authors: Mackey Tim K.
Published: October 2019

Corruption in the health sector has been a "dirty secret" in the health policy and international development community, but recent global activities point to a day when it will no longer be neglected as a key determinant of health. To further explore next steps forward, this commentary applies the Kingdon’s multiple-streams framework (MSF) to assess what opportunities are available to mobilize the global agenda to combat health corruption. Based on this analysis, it appears that Kingdon’s problem, policy, and political streams are coalescing to create a policy window opportunity that can be leveraged based on recent developments in the global health and international development community around corruption. This includes the recent formation of the Global Network on Anti-Corruption, Transparency and Accountability (GNACTA) led by the World Health Organization (WHO), the Global Fund, and the United Nations Development Programme in 2019. It also includes bridging shared goals of addressing corruption in order to make progress towards health-specific goals in the United Nations (UN) Sustainable Development Goals (SDGs) and for achieving universal health coverage.
Social Contact and Taiwanese Political Identity Change in Taiwanese Student Delegations Visiting Mainland China
Authors: Wang Chia-Chou
Published: October 2019

This study investigates whether visiting the authoritarian nation of China reduces Taiwanese youths’ identification with the democratic Taiwan. There is a significant reduction in the students’ Taiwanese political identity following their visit, namely a reduction of 0.06 on a scale from 1 to 4.
Presencia y duración de sonidos cardíacos en caballos sanos en gran altura
Authors: Arévalo Ana María , Martínez Anamaría , Ortíz Laura Sofía , Vargas-Pinto Pedro
Published: October 2019

Se da a conocer la presencia y duración de sonidos cardíacos en 24 equinos sanos habitantes de una zona ubicada a 2600 msnm. La toma de los datos se realizó mediante fonocardiografía directamente sobre la zona precordial. En todos los equinos se identificaron los sonidos 1 y 2. El sonido 4 estaba presente en el 87.5% de los equinos y el sonido 3 fue detectado solo en el 29.2% de los individuos. El estudio muestra la presencia común del sonido 4 en contraste con la baja presentación del sonido 3 en caballos sanos.
Genetic characterization of the Mirgorod pig breed, obtained by analysis of single nucleotide polymorphisms of genes
Authors: Vashchenko P. , Balatsky V. , Pocherniaev K. , Voloshchuk V. , Tsybenko V. , Saenko A. , Oliynychenko Ye. , Buslyk T. , Rudoman H.
Published: October 2019

Aim. To determine genetic characteristics of the Mirgorod pig breed by analysis of 25 SNPs of 22 genes and to conduct the associative analysis of genes MC4R (SNP c.1426 G > A), LEP (SNP g.2845 А ˃ Т), GH (BsuRI- polymorphism), CTSF (SNP g. 22 G > C) with productive traits of animals. Methods. Blood samples of pedigree Mirgorod pigs, bred at SI «Experimental farm named after Decemberists», Poltava region, were used for the studies. DNA genotyping was performed by PCR-RFLP and TaqMan. Results. Specifi c features of the breed were determined in terms of gene allele frequencies, high level of genetic variability (He – 0.326) and allelic diversity (mean number of alleles per locus – 1.96). The KPL2/m allele that causes genetic anomaly of ISTS is absent among investigated Mirgorod pigs, and the recessive RYR1 g.1843T allele, responsible for stress sensitivity of pigs, occurs at a low frequency (0.04). Unlike other breeds, a relatively high frequency of the minor allele g.15A (0.16) of CTSK and polymorphism of the LEP gene (SNP g.3996 T > C) (He – 0.455) was observed. Statistically signifi cant associations of polymorphisms have been established: MC4R (SNP c.1426 G > A) with age of gaining 100 kg, the thickness of backfat and the Eye Muscle Area, GH/BsuRI with the age of gaining 100 kg, and CTSF (SNP g. 22G > C) with Eye Muscle Area. There was a trend of statistically signifi cant differences between groups of pigs with different genotypes of LEP (SNP g.2845 А ˃ Т) and the thickness of the backfat (p = 0.09). Conclusions. It is reasonable to carry out the restoration of the gene pool of the Mirgorod pig breed, taking into account the SNPs of the studied genes and their associations with the productive traits. It is expedient to give preference to pigs with SNP genotypes с.1426 MC4R GA, MC4R AA, g. 22 CTSF CC, g.2845 LEP TT for breed reproduction.
AN UPDATE ON THE IXODES RICINUS MICROBIOME
Authors: Kmeť Vladimir , Čaplová Zuzana
Published: October 2019

Ixodes ricinus is vector in the transmission of many important infectious diseases in human and animals. There is still minimal information available on the bacterial agents associated with ticks found in Slovakia. We performed a survey of the bacterial communities associated with Ixodes ricinus collected from forest area near a great city aglomeration. Bacterial 16S rRNA hypervariable region amplicon libraries prepared from the Ixodes ricinus females were sequenced on Illumina MiSeq platform. We detected a total of 107 bacterial genera and order Clostridiales and class Bacilli (with more than 100 reads). Dominant taxa included the tick endosymbionts e.g. spotted fever group (Rickettsia 21998 reads) and Coxiella (10715 reads). Second dominant species was mycoplasma Spiroplasma ixodetis (9554 reads).
Dominant enviromental soil bacteria were Pseudomonas (6741 reads), Nocardiodes (4753 reads), Brevundimonas (2797 reads), Devosia (2797 reads) Aureimonas (1398 reads), Actinomycetospora (964 reads), Terrimonas (962 reads), Pedobacter (1139 reads), Methylobacterium (956 reads), Rhodococcus (945 reads), Williamsia (832 reads), Rhizobium (787 reads), Mesorhizobium (631 reads), Rhizobium (602 reads) and Spirosoma (486 reads) .
Firmicutes were only 280 reads with 151 reads of Clostridia and 128 reads of Bacilli (include Staphylococcus and Bacillus ). The cultivation and Maldi Tof analysis revealed seven species of coagulase negative staphylococci (CoNS) i.e., Staphylococcus epidermidis, S. capitis, S.haemolyticus, S.hominis, S. pasteuri, S.chromogenes, S.warneri and Micrococcus luteus. Antibiotic resistant CoNS with msrA and blaZ genes were detected. Five species of bacilli i.e. Bacillus cereus, B. licheniformis , B. thuringiensis and B. mycoides and two species of Brevibacillus i.e. B. parabrevis and B. agri were detected by Maldi Tof, also. The results of the next generation sequencing revealed a new look at the complexity of the Ixodes ricinus microbiome.
Trends of Suicidal Behaviors Among High School Students in the United States: 1991–2017
Authors: Lindsey Michael A. , Sheftall Arielle H. , Xiao Yunyu , Joe Sean
Published: October 2019

OBJECTIVES:

To determine if racial and ethnic subgroups of adolescents are at high risk for engagement in suicidal behaviors.

METHODS:

Using the nationally representative school-based Youth Risk Behavior Survey from the years 1991 to 2017, we conducted logistic regression analyses to examine trends by different racial and ethnic groups, with each suicide indicator serving as a dichotomous outcome. Participants included 198 540 high school students.

RESULTS:

Across all sex and race and ethnic groups, there were significant linear decreases in self-reported suicidal ideation and suicide plans from 1991 to 2017. Female adolescents (odds ratio [OR], 0.98; P < .001) had significant decreases in attempts over time. Black adolescents had positive linear trends for suicide attempts among both boys (OR, 1.04; P < .001) and girls (OR, 1.02; P = .003). Black adolescent boys (OR, 1.04; P = .048) had a significant linear increase in injury by attempt.

CONCLUSIONS:

The results suggest that, over time, black youth have experienced an increase in suicide attempts, which is troubling because attempts are the most prominent risk factor associated with suicide death. For black boys, a significant increase in injury by attempt occurred, which suggests that black boys may be engaging in increasingly lethal means when attempting suicide. Examining trends of suicidal thoughts and behaviors over time by sex and race and ethnicity allow us to determine where to focus prevention and intervention efforts. Future research should examine the underlying reasons for these changes observed in US high school students.
Organizational and economic mechanism of quality management of staffing of agro-industrial complex of the region
Authors: Anisimova Natalia
Published: October 2019

In article theoretical justification of essence and contents of the term «staffing» is given, features of process and resource approaches to its formulation are considered. On the basis of monographic and comparative methods of a research differences in the concepts «staffing» and «personnel security» are revealed, the directions of application of these terms in scientific literature are shown.
The purpose of writing of article was development and theoretical and methodical justification of the organizational and economic mechanism of quality management of staffing of agro-industrial complex at the regional level. The regional level of the conducted research was caused by the specifics of agricultural production allowing to differentiate the agrarian focused regions in the context of their staffing.
In article it is defined that intrinsic characteristic of staffing includes three obligatory components: educational, branch and regional. At the same time education as the separate system and branch of economy has to participate in process of staffing not only at a stage of obtaining basic professional knowledge, but also increase the personnel potential of the worker throughout all his work. In turn, the organizational and economic mechanism of quality management of staffing of agrarian and industrial complex of the region will be based on objective assessment of a system of agrarian formation of various levels, definition of instruments of their interaction and synergetic influence at each other.
In conclusions of the conducted research it is formulated that effective functioning of the organizational and economic mechanism of quality management of staffing of agrarian and industrial complex has to be based on the concept of interindustry balance of agrarian labor market and the system of agrarian formation of the region that will promote performance of strategic purposes of development of regional agro-industrial complex.
Book review
Authors: Lewis Roger
Published: October 2019

The men who drowned Dolgarrog
Innovative Intestification of Testing of Strength Endurance in Physical Education of Students With Chronic Diseases
Authors: Koryahin V. M. , Blavt O. S. , Ponomaryov S. V.
Published: October 2019

The study objective is to substantiate and implement modern information-communication technologies (ICT) means for improving the testing of strength endurance of hands and upper body of students with chronic diseases in physical education. 

Materials and methods. To solve the research tasks used the methods of comparing and contrasting are used and analysis, synthesis, abstraction, formalization and technical modelling. 

Results. The result of a scientific search aimed at integrating ICT into test control of strength endurance of students with chronic diseases is a device of capacitive sensor testing. The designed capacitive touch tester is based on a combination of modern nanotechnology and microprocessor systems, including smart phone’s, tablets, etc. It is a constructive solution for electronic measuring systems of spatial position of objects based on capacitive sensor devices. 

Conclusions. The effectiveness of using the designed device in testing students’ of strength endurance of hands and upper body is achieved through the ease of use and compactness of the device, student-friendly testing procedure and the efficiency and reliability of control.
Z dziecięcych refleksji nad językiem
Authors: Manasterska-Wiącek Edyta
Published: October 2019

Celem niniejszego artykułu jest lingwistyczna analiza wypowiedzi dziecięcych pod kątem ich refleksji (językowej i metajęzykowej) nad przyswajanym językiem. Badanie będzie próbą odpowiedzi na pytanie, na jakich poziomach, w jakim wymiarze badane dzieci obserwują mowę oraz jak mówią o języku za pomocą samego języka. O ile na gruncie psychologii odnotowuje się prace poświęcone metajęzykowi, o tyle w lingwistyce trudno dotrzeć do badań skoncentrowanych na metajęzyku tak specyficznego użytkownika języka, jakim jest dziecko. Niejednorodność poglądów psychologów odnośnie do rozumienia pojęcia świadomości (meta)językowej pozwala mimo wszystko oprzeć analizę na podstawowym założeniu, że o zachowaniach językowych – by mogły zostać uznane za metajęzykowe – można mówić wtedy, kiedy człowiek wykonuje je świadomie, kiedy posiada zdolność refleksji nad językiem oraz wykazuje intencję kontrolowania własnej aktywności.

Część empiryczna artykułu, obfitująca w liczne wypowiedzi dzieci świadczące o ich refleksji nad językiem, pozwoliła na wyciągnięcie konkretnych wniosków: dzieci myślą o tym, co i jak mówią, analizują wypowiedzi swoje oraz innych; refleksji dziecięcej podlegają różne poziomy języka: fonologiczny, leksykalny, składniowy, analizują i różnicują skład morfemowy leksemów, zwracają uwagę na stałe połączenia wyrazów, identyfikują określony rejestr językowy oraz kwestie stylistyczne dotyczące użycia wyrazów, nie operując sprawnie aparatem pojęciowym są w stanie same wymyślić własny, umieją bawić się słowami oraz ich znaczeniami.
The Relationship between Mutation in HOXB1 Gene and Acute Myeloid Leukemia
Authors: Vahidi Mehrjardi Mohammad Yahya , Aghaei Zarch Seyed Mohsen , Dehghani Mohammadreza
Published: October 2019

Background: HOX genes are an exceedingly preserved family of homeodomain-involving transcription factors. They are related to a number of malignancies, comprising acute myeloid leukemia (AML). This study aimed to evaluate the effect of HOXB1 7bp deletion mutation on HOXB1gene expression in 36 individuals.
Materials and Methods: The present cross-sectional study was done on a large Iranian family. In this experimental study, 5 homozygous 7bp deletion individuals along with their unaffected siblings and their parents were investigated. The candidate gene, HOXB1 was screened and analyzed in blood samples of these participants. After RNA extraction, cDNA was synthesized according to manufacturer’s protocol. HOXB1 expression level was analyzed by 2ΔΔCT method. All laboratory procedures used in this experimental study were carried out in genetic laboratory of Shahid Sadoughi University of Medical Sciences.
Results: Sequence analysis of HOXB1 gene by ABI Prism 3130 Genetic Analyzer (Applied Biosystems, Foster City, CA, USA) revealed a family with 5 homozygous (22±17 years) and 22 healthy heterozygous carriers (42±19 years) for 7bp deletion in HOXB1 gene along with 9  healthy wild type (55±41 years). Gene expression analysis by RT-qPCR demonstrated that expression level of HOXB1 gene in wild type and heterozygous carriers specimens had similar levels (p=0.05).
Conclusion: Although HOXB1 mutations has been reported in AML, but association between HOXB1 mutation and AML was not found in our study. Additionally, HOXB1 expression levels showed no significant difference between wild type and heterozygous carriers. So, HOXB1 gene expression cannot provide a powerful tool to differentiate wild type from heterozygous carries.
Assessment of Pancreatic Iron Overload in Transfusion Dependent Thalassemic Patients
Authors: Hashemieh Mozhgan
Published: October 2019

Advances in the management of transfusion dependent thalassemic patients have improved the survival of these patients. The most important consequence of repeated and frequent transfusions is iron accumulation in vital organs. The magnetic resonance imaging (MRI) is a non-invasive and valid technique for the estimation of iron stores. Despite multiple studies about cardiac and liver MRI T2*, there is limited experience about pancreatic MRI. Although there is a weak correlation between hepatic and pancreatic siderosis, MRI assessment of iron deposition in the pancreas can reduce cardiac morbidity. Pancreatic siderosis may be a predictor for the development of glucose dysregulation. Pancreatic R2* > 100 Hz is a risk factor for glucose intolerance or even overt diabetes. Splenectomy can accentuate the pancreatic iron overload. Early intensive chelation therapy in thalassemia patients can reverse glucose metabolism impairment. In this review, the MRI assessment of pancreatic iron overload in transfusion dependent thalassemia, the correlation between pancreas with liver and myocardial hemosiderosis and the importance of pancreatic iron overload in pathogenesis of diabetes mellitus in these patients were discussed.
Prevalence of Chronic Diseases in Elderly Living in Yazd Nursing Homes, and Its Relations with Oral Soft Tissue Lesions (OSTL)
Authors: Owlia Fatemeh , Bahadori Lida , Ahadian Hakimeh , Hakimian Roquayeh , Kazemeini Seyed Kazem
Published: October 2019

Introduction: oral as the mirror of body could have a vital role in general health. According to aging of Iranian population, having knowledge about prevalence of systemic disease of geriatric population could be helpful in selection of correct approach in community health. The purpose of this study was to determine Prevalence of medical condition and relation to oral soft tissue lesions of geriatric in Yazd.
Methods: In this cross-sectional descriptive study, all of the nursing homes in Yazd, were Studied. Of 327 residents, 267 person older than 65 years old who could and want to cooperate with examiner, entranced to the study. Demographic data, systemic disease, drugs, oral habits like smoking and alcohol use and denture use extracted. Qualified elderly were examined for oral soft tissue lesions. Data were analyzed by SPSS 17 and chi square test.
Results: The most prevalence of systemic disease of the geriatric population were gastrointestinal disease (67%), Psychiatric disorders (54.3%), cardiovascular diseases (41.9%) and metabolic disease (15.7%) respectively. There was a significant relation between psychiatric disease and oral soft tissue lesions.(p=0.007).
Conclusion: According to attained results, Prevalence of oral soft tissue lesions were higher in the elderly with Psychiatric disorders.
Emociones en la educación en Colombia, algunas reflexiones
Authors: Herrera Lucia , Buitrago Rafael Enrique
Published: October 2019

En esta dirección es importante recordar que las emociones han sido abordadas a lo largo de la historia por distintas disciplinas como la biología, la filosofía —desde los griegos—, el psicoanálisis —en especial freudiano—, la psicología —conductista, cognitiva y positiva—, la sociología, el análisis facial de las emociones, la neurociencia afectiva y la educación. Aun así, por mucho tiempo las emociones fueron consideradas como irrelevantes y accesorias, motivo por el cual había que ignorarlas, e incluso reprimirlas. Desde el contexto escolar la tendencia fue la misma, es decir, se creía que había que excluirlas porque la escuela estaba encargada del pensamiento y el aprendizaje. Se pensaba que las emociones no tenían nada que ver con los procesos cognitivos (Buitrago & Herrera, 2013), motivo por el cual era impertinente permitir su presencia en las aulas. Desde luego, y por fortuna, esta perspectiva se ha modificado con los años, en primer lugar, por el creciente incremento de resultados de investigación, los cuales aumentaron desde que en 1990 se publicó un artículo académico de Peter Salovey y John Mayer, en el que se desarrolló el concepto de inteligencia emocional [IE], lo cual sirvió de base para el fortalecimiento del constructo (Buitrago, 2012); pero también, desde la perspectiva del público en general, cuando en 1995 Daniel Goleman publica su best seller, Inteligencia Emocional.
An Overview of Systematic Reviews and Meta Analyses on Acupuncture for Post-Acute Stroke Dysphagia
Authors: Tian Zi-Yu , Liao Xing , Gao Ying , Liang Shi-Bing , Zhang Chong-Yang , Xu De-Hao , Liu Jian-Ping , Robinson Nicola
Published: October 2019

Background: Many randomized controlled trials (RCTs) and systematic reviews (SRs) on acupuncture treatment for post-acute stroke dysphagia have been published. Due to conflicting results an overview of SRs to summarize and assess the quality of this evidence to determine whether acupuncture is effective for this disease was conducted. Methods: Seven databases were searched for SRs and/or Meta-analysis of RCTs and quasi-RCTs on acupuncture for post-acute stroke dysphagia. Two authors independently identified SRs and meta-analyses, collected data to assess the quality of included SRs and meta analyses according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and the revised Assessment of Multiple Systematic Reviews (AMSTAR 2). Results: 31 SRs were identified. Quality of 22 SRs was critically low, 5 SRs were low, and 4 Cochrane SRs were moderate when evaluated by AMSTAR2. 17 SRs reported 85.2-96.3% items of PRISMA. Five SRs included explanatory RCTs, 16 SRs included pragmatic RCTs, and 10 SRs included both. Conclusion: Currently evidence on the effectiveness of acupuncture on post-acute stroke dysphagia is low quality. Type of study appeared to have no direct influence on the result, but the primary outcome measures showed a relationship with the quality of SRs. High quality trials with large sample sizes should be the focus of future research. PROSPERO REGISTRATION NUMBER: CRD42019134163
Usage Surface Deflection Data for Performance Prediction in Flexible Pavement
Authors: Karballaeezadeh Nader , Zaremotekhases Farah , Nabipour Narjes , Shamshirband Shahaboddin , Mosavi Amir
Published: October 2019

The conventional method used for calculating pavement condition index (PCI) has two major drawbacks: safety problems during pavement inspection, and human error. This paper proposes a method for removing these problems. The proposed method uses surface deflection data in falling weight Deflectometer test to estimate PCI. The data used in this study were derived from 236 pavement segments taken from Tehran-Qom freeway in Iran. The data set was analyzed using multi layers perceptron (MLP) and radial basis function (RBF) neural networks. These neural networks were optimized by levenberg-marquardt (MLP-LM), scaled conjugate gradient (MLP-SCG), imperialist competitive (RBF-ICA), and genetic (RBF-GA) algorithms. After initial modeling with four neural networks mentioned, the committee machine intelligent systems (CMIS) method was adopted to combine the results and improve the accuracy of the modeling. The results of analysis have been verified by the four criteria of average percent relative error (APRE), average absolute percent relative error (AAPRE), root mean square error (RMSE) and standard error (SD). The best reported results belonged to CMIS, including APRE=2.3303, AAPRE=11.6768, RMSE=12.0056, and SD=0.0210.
CSI NGS Portal: An Online Platform for Automated NGS Data Analysis and Sharing
Authors: An Ömer , Tan Kar-Tong , Li Ying , Li Jia , Wu Chan-Shuo , Zhang Bin , Chen Leilei , Yang Henry
Published: October 2019

Next-generation sequencing (NGS) has been a widely-used technology in biomedical research for understanding the role of molecular genetics of cells in health and disease. A variety of computational tools have been developed to analyse the vastly growing NGS data, however, they often require bioinformatics skills and tedious work to handle with. Moreover, processing raw data such as genome alignment and expression quantification consume a significant amount of time before having the data ready for downstream analyses. To facilitate data processing steps minding the gap between biologists and bioinformaticians, we developed CSI NGS Portal, an online platform which gathers established bioinformatics pipelines to provide fully automated NGS data analysis and sharing in a user-friendly website, developed in PHP and JavaScript with an integrated MariaDB database running on a dedicated Linux server. The portal currently provides 14 standard pipelines for analysing NGS data from DNA, RNA, smallRNA, ChIP, RIP, 4C, SHAPE, circRNA, eCLIP and Bisulfite sequencing, and is flexible to expand with new and customised pipelines. The users can upload raw data in fastq format and submit jobs for the desired analyses in a few clicks, and the results will be self-accessible via the portal to view/download/share in real-time. The output can be readily used as the final report or as an input for other tools depending on the pipeline. Overall, CSI NGS Portal helps researchers rapidly analyse their NGS data, share with colleagues and keep it organised without the aid of a bioinformatician. The website is freely available at: https://csibioinfo.nus.edu.sg/csingsportal
Fault Detection and Classification of Shunt Compensated Transmission Line Using Discrete Wavelet Transform and Naive Bayes Classifier
Authors: Aker Elhadi , Otman Mohammad Lutfi , Veerasamy Veerapandiyan , Aris Ishak , Wahab Noor Abdul , Hizam Hashim
Published: October 2019

This paper presents the methodology to detect and identify the type of fault that occurs in shunt connected static synchronous compensator (STATCOM) transmission line using a combination of Discrete Wavelet Transform (DWT) and Naive Bayes classifier. To study this, the network model is designed using Mat-lab/Simulink. The different faults such as Line to Ground (LG), Line to Line (LL), Double Line to Ground (LLG) and three-phase (LLLG) fault are applied at different zones of system with and without STATCOM considering the effect of varying fault resistance. The three-phase fault current waveforms obtained are decomposed into several levels using daubechies mother wavelet of db4 to extract the features such as standard deviation and Energy values. The extracted features are used to train the classifiers such as Multi-Layer Perceptron Neural Network (MLP), Bayes and Naive Bayes (NB) classifier to classify the type of fault that occurs in the system. The results reveal that the proposed NB classifier outperforms in terms of accuracy rate, misclassification rate, kappa statistics, mean absolute error (MAE), root mean square error (RMSE), relative absolute error (RAE) and root-relative square error (RRSE) than MLP and Bayes classifier.
Staged Treatment of Chronic Locked Fracture-Dislocation of the Calcaneus
Authors: Liu Jane , Slotkin Steven , Zeni Ferras
Published: October 2019

Case:

A 49-year-old woman presented 5 months after a missed locked fracture-dislocation of the calcaneus. This was treated with a Taylor spatial frame for deformity correction before definitive open reduction internal fixation with subtalar fusion. She is now 4 and a half years postoperative with an active lifestyle and no pain.

Conclusions:

Staged treatment using a Taylor spatial frame is a useful tool to address chronic locked chronic fracture-dislocations of the calcaneus.
Pseudoaneurysm of the Popliteal Artery Leading to Foot Drop After Arthroscopic Anterior Cruciate Ligament Reconstruction: A Rare Complication
Authors: Joshi Amit , Singh Nagmani , Pradhan Ishor , Basukala Bibek
Published: October 2019

Case:

A 32-year-old man underwent arthroscopic anterior cruciate ligament reconstruction (ACLR) using hamstring autograft. He complained of persistent posterior knee pain in the postoperative period and at 4 weeks postsurgery developed foot drop and intense posterior knee pain. On clinicoradiological evaluation, a popliteal pseudoaneurysm (PSA) was diagnosed. The patient underwent surgical exploration, excision of the PSA, and primary repair of the popliteal artery. The foot drop recovered at 3 months post–second surgery follow-up.

Conclusions:

Persistent posterior knee pain and popliteal fossa swelling in a patient after ACLR should raise a suspicion of popliteal PSA. Identifying these lesions early can prevent further complications such as common peroneal nerve palsy.
A case of tularemia in Chuvash Republic
Authors: Anisimova T. A. , Andreeva L. V. , Trofimova E. A. , Stekolschikova I. A. , Krasnov M. V.
Published: October 2019

The purpose of this article was to study the epidemiological situation of tularemia – zoonotic natural focal disease in the Russian Federation (RF) in General and in the Chuvash Republic (CR) in particular. The paper presents a clinical case of tularemia after prolonged epidemiological well-being in the CR. The material on the incidence of tularemia in the CR from 2007 to 2017 was studied. In total for the analyzed period in the Republic 2 serologically confirmed cases of tularemia among the adult population infected at rafting on the Ural river in Bashkortostan were registered. It was found that despite the epidemic well-being, in the territory of the Russian Federation there is a possibility of infection with tularemia microbe in the places of circulation of the pathogen and for timely diagnosis of infection, the doctor must remember the most manifest symptoms of the disease, which are fever, skin rashes and lymphadenitis. The sporadic nature of the disease, the variety of clinical manifestations of tularemia, the absence of specific symptoms in the early days of the disease are the causes of diagnostic errors.
Analysis of the incidence of newborn's healthcare associated infections and intrauterine infections in several maternity hospitals in Moscow
Authors: Ivanova M. V.
Published: October 2019

Purpose of the study. To estimate the incidence of newborn's healthcare associated infections (HAI) and intrauterine infections in the Russian Federation, Moscow and three maternity hospitals in Moscow. Materials and methods. The retrospective epidemiological analysis of neonates HAIs and intrauterine infections during 2008–2017 was performed in the Russian Federation and Moscow and during 2009–2017 in three maternity hospitals (MH) in Moscow. In this study the maternity hospitals would be known as MH № X01, № X02 and № X03. Also, in this study, the calculation and analysis of the proportion of cases of newborn's HAIs and intrauterine infections with laboratory confirmation were performed in Moscow's maternity hospitals. The data was selected from Form № 2 for the Russian Federation and Moscow. Also, the data of the maternity hospitals was drawn from the base of the Hygiene and Epidemiology Center in Moscow. The morbidity rate of HAIs and intrauterine infections of newborns was counted on 1,000 newborns. Microsoft Office Excel 2010 software packages were used for this purpose. The calculation of the increase / decrease rate was made by the method of least squares. Results. The incidence of intrauterine infections and HAIs of newborns in the Russian Federation, Moscow, and maternity hospitals is characterized by the next mutual trends – a significant dominance cases of intrauterine infections' over the cases of HAI, extremely irregular registration and distribution of the nosologies' proportion. Concerning to the dynamics of morbidity during 2009–2017 in maternity hospitals in Moscow, the HAIs newborn's incidence has tendency of decline, and intrauterine infections has considerable increase of the incidence. This consistent pattern is observed in all described maternity hospitals. The structure of the incidence in maternity hospitals is similar to each other. The leading diagnoses among intrauterine infections are intrauterine infection without a lesion and intrauterine pneumonia. The interest of other infections is about 1%. The proportion of cases with laboratory confirmation of the newborn's HAIs and intrauterine infections is extremely small. Besides that, there were identified some indirect signs of poor-quality registration of nosocomial infections. Conclusion. Significant difference in the number of cases of newborn's HAIs and intrauterine infections and their multidirectional incidence trends, once again point to the concealment of a part of nosocomial infections, under such diagnoses, as intrauterine infection without a lesion and intrauterine pneumonia. Laboratory confirmation of cases of HAIs and intrauterine infections in the maternity hospitals is carried out only by a small proportion of patients. Thereby, the incidence rates of HAIs of newborns and intrauterine infections in maternity hospitals in Moscow raise doubts about their reliability.
The practice of microbiological monitoring of the dynamics antibiotics resistance for Infection prevention and control program
Authors: Tonko O. V. , Kolomiets N. D. , Hanenko O. N. , Levshina N. N. , Goylova A. V.
Published: October 2019

In the last decade, there has been a sharp increase in the prevalence of various types of antimicrobial resistant bacteria, including enterobacteria, resistant to carbapenems and multiresistant strains of Acinetobacter baumanii and Pseudomonas aeruginosa, S. аureus resistant to betalactam antibiotics and glycopeptides. The aim of the study was to assess the prevalence of multidrug-resistant microorganisms in healthcare organizations in Minsk. To compare the structure and resistance of microorganisms, the data obtained in the study of isolates isolated from the blood of patients from anesthesiology and resuscitation departments of children's hospitals of health organizations for the adult population of Minsk in 2015–2017 were analyzed. It has been established that the structure of the main clinically significant microorganisms isolated from the blood samples of adult patients has differences from the microorganisms isolated from the blood of children's hospitals patients. Significant differences in the level of antibiotic resistance of isolates isolated from patients in pediatric hospitals and hospitals for adults have been established. Thus, the level of antibiotic resistance of Acinetobacter baumannii isolates to ampicillin / sulbactam, ceftazidime, cefepime, ciprofloxacin is higher in adult healthcare organizations than in healthcare organizations for children, while the level of resistant isolates to gentamicin is higher (p < 0,05). Resistance was high for all tested antimicrobials. It has been shown that the level of antibiotic resistance of isolates from samples from adult patients is higher compared to that in the children's hospitals. A significant difference was found in the level of resistance of Klebsiella pneumoniae ss. pneumoniae to ampicillin, ceftazidime, gentamicin (p < 0,05). The level of resistant isolates of Staphylococcus aureus ss. aureus, from blood samples from patients in adult hospitals, to oxacillin, gentamicin, levofloxacin, erythromycin is higher compared to that in the pediatric patients.
Successful science without miracles
Authors: Ниинилуото И.
Published: October 2019

Science is highly successful in making empirical predictions and guiding our practical actions. This paper defends the so-called ‘ultimate argument for scientific realism’ by claim- ing that this empirical and pragmatic success of scientific theories would be a miracle unless they are true or truthlike. This argument is abductive in Charles Peirce’s sense, as it appeals to inference to the best explanation.
Preface
Authors: Карпенко А.С.
Published: October 2019

The history of Finnish-Soviet Logic Colloquium
Об одном обобщении теоремы Гливенко
Authors: Попов В. М.
Published: October 2019

В [4] В.И. Гливенко получил результат, который в настоящее время принято называть теоремой Гливенко и который устанавливает эквивалентность между утверждением о принадлежности формулы классической пропозициональной логике и утверждением о принадлежности двойного отрицания этой формулы интуиционистской пропозициональной логике. Теорема Гливенко является важным достижением в области исследований связей между логиками, проводимых с применением погружающих операций. Здесь предлагается обобщение теоремы Гливенко и описывается основанный на этом обобщении способ построения аналогов утверждения, являющегося некоторой специальной формой теоремы Гливенко. В статье использованы построенные автором подлогики классической пропозициональной логики, из которых главную роль играет логика $Int_{<\omega,\omega>}$ (она является также подлогикой интуиционистской пропозициональной логики). Обращение к логике $Int_{<\omega,\omega>}$ поз- волило провести такое обобщение теоремы Гливенко, которое распространяется на некоторый обширный (континуальной мощности) класс подлогик интуиционистской пропозициональной логики.
On the Definitional Embeddability of Some Elementary Algebraic Theories into the First-Order Predicate Calculus
Authors: Шалак В. И.
Published: October 2019

In this article we prove a theorem on the definitional embeddability into first-order predicate logic without equality of such well-known mathematical theories as group theory and the theory of Abelian groups. This result may seem surprising, since it is generally believed that these theories have a non-logical content. It turns out that the central theory of general algebra are purely logical. Could this be the reason that we find them in many branches of mathematics? This result will be of interest not only for logicians and mathematicians but also for philosophers who study foundations of logic and its relation to mathematics.