bluuebunny/crossref_metadata_2025 huggingface dataset:
Platelet-specific antibodies are unrelated to the bleeding severities in children with newly diagnosed ITP and a severe decline of platelets
Authors: Dong Shuyue , Fu Lingling , Gu Hao , Xie Xingjuan , Ma Jingyao , Ma Jie , Chen Zhenping , Wu Runhui
Published: June 2022

Background and objective: Immune thrombocytopenia (ITP) is an
autoimmune-mediated hemorrhagic disease, which is characterized by
thrombocytopenia and bleeding manifestation. The treatment options of
ITP in children are selected based on bleeding severities and the
treatment selection is critical in children with a serious decline in
platelet count (platelet count of <10×10
/L). Although it is well known that platelet-specific
antibodies play a key role in ITP, the relationship between different
platelet-specific antibodies and bleeding severities is unclear. This
study aimed to analyze the relationship between platelet-specific
antibodies (anti-GPIIb/IIIa and anti-GPIb/IX antibodies) and bleeding
severities in children with newly diagnosed ITP and a serious decline in
platelet count. Method: This study was a single-center
prospective observational study that analyzed children with newly
diagnosed ITP and platelet count of less than 10×10
/L from June 2018 to September 2021 in our Hospital.
They were classified into mild-moderate and severe groups based on the
treatments. Platelet-specific antibodies and titers were detected using
a kit, PAKAUTO. We analyzed the relationship of bleeding severities with
platelet-specific antibodies/titers .Results: A total
of 86 cases were enrolled including 57 males and 29 females with a
median age of 35 months (range 1 month to 198 months). And 11 cases were
categorized as the mild-moderate group and 75 cases were categorized as
the severe group based on bleeding severity score. The positive rates
were 68.6% for anti-GPIIb/IIIa and 65.1% for anti-GPIb/IX. There was
no significant difference in anti-GPIIb/IIIa and anti-GPIb/IX antibodies
between the two bleeding severity groups (
χ=0.530, P=0.467;
χ<0.001, P=1.000), and also
no difference was found between the two groups when two antibodies were
analyzed together ( χ=2.071, P=0.558).
The antibody titers in plasma and eluent were also detected, but no
significant difference was found in the antibody titer ratios between
the two bleeding severity groups ( P<0.05 in four
plasma and eluent groups). Conclusion: Platelet-specific
antibodies (anti-GPIIb/IIIa and anti-GPIb/IX antibodies) were not
related to the bleeding severities in children with newly diagnosed ITP
and serious decline of platelet count.
Uji Aktivitas Antikolesterol Kombinasi Ekstrak Teh Oolong, Buncis Dan Kayu Manis
Authors: Fauzi Ahmad , Sujono Tanti Azizah , Saifudin Azis , Sri Wahyuni Arifah
Published: June 2022

Hyperlipidemia has an important role in the occurrence of cardiovascular, cerebrovascular, and peripheral vascular diseases. High cholesterol and LDL levels in the blood are at risk of causing various diseases such as atherosclerosis, pancreatic dysfunction and kidney disorders. Meanwhile, high triglyceride levels can cause impaired liver, pancreas and kidney function. Green bean, oolong tea and cinnamon are plants that can lower cholesterol levels. Oolong tea contains catechins, Green Bean contain phytosterols and cinnamon contains cinnamaldehyde. Determination of secondary metabolite levels of extracts was carried out using the Liquid Chromatography – Mass Spectroscopy (LC-MS) method. The activity test was carried out with 30 Wistar white rats which were divided into 6 test groups. The normal control group was treated with CMC-Na without feeding hypercholesterolemia, the positive control group was treated with simvastatin 0.4 mg/KgBW, the negative control group was treated with CMC-Na, the test groups 1, 2 and 3 were treated with cinnamon extract, oolong tea and green bean, respectively (150:50:50 mg/KgBW), (50:150:50 mg/KgBW) and (50:50:150 mg/KgBW). The detected metabolite content was cinnamaldehyde in cinnamon up to 10%, catechins in oolong tea up to 12% and stigmasterol in beans as much as 3.4%.The results obtained by test group 1 and test group 2 can reduce cholesterol and triglyceride levels (p0.05). All test groups had no significant effect on HDL and LDL levels.
Does contract farming really matter in cassava farms productivity in Iseyin Local Government Area, Oyo State, Nigeria?
Authors: Obi-Egbedi Ogheneruemu , Osanyinlusi Oladele Ige , Adekunle Olatunde Bilikisu
Published: June 2022

Improving the productivity of smallholder farmers particularly in developing countries has taken different approaches. Contract farming is one of the approaches employed to increase farmers’ productivity. However, agricultural outcomes have not been consistent with contract farming in developing countries. Hence, we examined the effect of contract farming on productivity of cassava farmers in Iseyin Local Government Area of Oyo State, Nigeria. Primary data were collected using a multi-stage procedure to select the farmers. Descriptive and econometric methods were employed for data analysis. The findings revealed that farm size and years of education of the participants in contract farming in the area were significantly different from non-participants by 0.45 ha and 1.76 years, respectively. Years of education, farm size, planting improved cassava variety, price of cassava output and being a female cassava farmer were significant drivers of participation. The mean productivity of the cassava farmers was about 0.89. Non-participants showed a higher productivity than their counterparts in contract farming. Although farm size increased productivity of cassava farmers, household size and contract farming significantly reduced it in the area. Hence, it was concluded that contract farming does not always significantly improve agricultural outcomes. Planting high-yielding varieties coupled with best agronomic practices will better address the issue of declining productivity of the cassava farms in the area, alongside reduction in family size. Further, giving considerable attention to favourable technical supports and contract terms will improve contract farming effect on agricultural outcomes.
Convex linear combination of the controllability pairs for linear systems
Authors: Kaczorek Tadeusz , Klamka Jerzy
Published: June 2022

The convex linear combination of the controllability pairs of linear continuous-time linear systems is defined and its properties are discussed. The main result is obtained using pure algebraic methods. In the illustrative examples different cases of linear convex combinations are analyzed.
Introducing and solving the hesitant fuzzy system AX = B
Authors: Babakordi Fatemeh , Allahviranloo Tofigh
Published: June 2022

In this paper the solution for hesitant fuzzy system as AX = B is introduced where A is an n × n known hesitant fuzzy matrix, B is an n × 1 known hesitant fuzzy vector and X is an n × 1 unknown hesitant fuzzy vector.

First, L
∞-norm and L
1-norm of a hesitant fuzzy vector are introduced. Then, the concepts of hesitant fuzzy zero, ’almost equal’ and ’less than’ and ’equal’ are defined for two hesitant fuzzy numbers. Finally, using a minimization problem; the hesitant fuzzy system is solved. At the end, some numerical examples are presented to show the effectiveness of the proposed method.
Pathogen Detection and Phylogenetic Analysis of Aethina tumida Murray in South Korea
Authors: Yoo Mi-Sun , Truong A-Tai , Choi Yong-Soo , Hong Ki-Jeong , Hwang Tae Jun , Seo Soo Kyoung , Seo Hyun-Ji , Jung Sukchan , Yoon Soon-Seek , Cho Yun Sang
Published: June 2022

The small hive beetle (SHB), Aethina tumida Murray, is a parasite of honey bee colonies and causes the fermentation of honey as well as colony collapse. Outbreaks have been confirmed in Africa, America, Europe as well as Asia, where an outbreak was reported in the Philippines and South Korea in 2014 and 2017, respectively. In South Korea, in September 2016, this honey bee parasite was first identified in apiaries in Miryang, Gyeongnam Province. However, the invasion pathway of SHB has not been identified, and honey bee pathogens harbored by SHB have not been well characterized. Therefore, phylogenetic analysis of SHB with the use of COI gene and detection of fourteen common honey bee pathogens were conducted in this study. The confirmation of the fourteen honey bee pathogens in SHB showed that this beetle carries black queen cell virus and deformed wing virus. Therefore, SHB could have a role in the spread of these viruses. The way of entry of the SHB to South Korea remains undetermined, but the phylogenetic analysis of the COI gene revealed that it was most similar to species found in the USA. There is an urgent need for national-level monitoring and quarantine measures for preventing the spread of SHB infestation in South Korea.
Use of Osmia bicornis L. for Pollination of Cyclamen persicum Mill. Cultivated in Greenhouse Environment During Winter Period
Authors: Fliszkiewicz Monika , Wasielewski Oskar , Giejdasz Karol
Published: June 2022

In this study, the pollinating potential of the red mason bee (Osmia bicornis syn. O. rufa) in seed production of a major ornamental plant - Persian cyclamen (Cyclamen persicum), was evaluated under horticultural farm conditions. The study was conducted under a greenhouse environment for five months, from October to the end of February. The juvenile hormone analogue methoprene supported the termination of bee diapause. Experimental results from Osmia pollination plots were compared with control plots that applied the hand-pollination method. Plants with flowers pollinated by the solitary bee had significantly more fruits than those pollinated by the hand method in November, December and February. In addition, significantly more seeds per capsule were produced by plants pollinated by O. bicornis from December to February. Finally, plants pollinated by Osmia bees produced more seeds than those hand-pollinated at all experimental months. These results showed that if the diapause of O. bicornis is successfully broken, this bee can be a very efficient pollinator in greenhouse environments, even during winter.
Bakteri patogen pada telepon genggam mahasiswa fakultas kedokteran Universitas Airlangga angkatan 2014
Authors: Mboe Ribka Brillyand Angeli , Purwanta Marijam , Djuari Lilik
Published: June 2022

Recently people use mobile phone in the places that have a high density of microorganisms such as in the hospital, in the kitchen, and in the toilet. Some studied stated that mobile phones played a role in transmission of pathogenic bacteria. Brady et al., reported that 9% to 25% of mobile phones were contaminated with pathogenic bacteria. This research was based on experimental laboratory. The samples were mobile phone, swabbed by wet sterile cotton bud and placed on MacConkey Agar plate and Blood Agar plate. The isolated bacteria were checked by Gram stained. Catalase test for Gram-positive cocci bacteria and specific biochemical test for Gram-negative bacilli bacteria were used to determine the genus of the bacteria. The samples were mobile phone belong to 2014-entering-year students of Medical Faculty of Airlangga University. The sampling method was simple random sampling. This experiment found that 100% of the samples were Staphylococcus spp. positive, 3,3% were Shigella spp. positive and 3,3% were Proteus spp. positive. From this experiment could be concluded that mobile phone  belong to 2014-entering-year students of Medical Faculty of Airlangga University were contaminated by pathogenic bacteria. The result of this experiment found that Shigella spp. and Proteus spp. were pathogenic bacteria on mobile phone belong to 2014-entering-year students of Medical Faculty of Airlangga University.
Hubungan penggunaan smartphone dengan sindroma mata kering pada mahasiswa fakultas keperawatan Universitas Syiah Kuala
Authors: Meutia Firdalena , Razali Rezania , Basri Saiful , Saminan Saminan , Nurafika Fanny Adlin
Published: June 2022

Sindroma mata kering merupakan suatu keadaan terjadinya defisiensi maupun penguapan berlebihan dari air mata. Sindroma mata kering biasanya sering terjadi pada usia 40 tahun, namun akhir-akhir ini sindroma mata kering juga ditemukan pada usia 40 tahun, hal ini diduga karena meningkatnya penggunaan perangkat elektronik seperti smartphone pada usia tersebut. Penelitian ini bertujuan untuk mengetahui korelasi penggunaan smartphone dalam hal ini yaitu durasi dengan sindroma mata kering pada mahasiswa Fakultas Keperawatan Universitas Syiah Kuala (Unsyiah). Penelitian ini merupakan penelitian analitik observasional dengan desain cross sectional. Terdapat 222 responden yang menjadi sampel penelitian diantaranya terdiri dari mahasiswa angkatan 2017-2019. Sampel diperoleh dengan teknik simple random sampling. Pengambilan data yaitu pada tanggal   9 hingga 16 Oktober 2020 dengan membagikan kuesioner penelitian melalui google form. Uji statistik menggunakan uji Spearman. Hasil yang didapatkan yaitu p value adalah 0,001 dan koefisien korelasi adalah 0,230, dari hal tersebut dapat disimpulkan terdapat hubungan dengan korelasi lemah antara penggunaan smartphone dengan sindroma mata kering pada mahasiswa Fakultas Keperawatan Unsyiah.Kata Kunci: Penggunaan smartphone, sindroma mata kering, mahasiswa.
ADENOKARSINOMA KOLON PADA BAYI BERUSIA 14 HARI
Authors: Ismida Fitri Dewi , Mariedina Causa Trisna , Safarianti Safarianti
Published: June 2022

Adenokarsinoma kolon merupakan salah satu jenis kanker yang paling banyak dijumpai, sekitar 15% dari seluruh kanker yang mematikan. Umumnya kanker ini terjadi pada usia dewasa dan jarang dijumpai pada anak-anak. Dilaporkan sebuah kasus adenokarsinoma kolon pada seorang bayi laki-laki berusia 14 hari yang disangkakan sebagai Hirschprung’s disease. Dilakukan pemeriksaan secara histopatologi terhadap massa tumor dari kolon. Setelah jaringan difiksasi dengan formalin 10%, dilakukan  pemrosesan standar menggunakan blok parafin dengan pewarnaan Hematoxylin Eosin. Jaringan kemudian dievaluasi di bawah mikroskop cahaya binokuler. Gambaran histopatologi jaringan dari kolon, tampak lapisan mukosa hingga serosa. Lapisan mukosa terdiri dari struktur kelenjar yang mengalami disorganisasi. Kelenjar dengan pelapis epitel yang proliferatif, inti bulat oval membesar, kromatin kasar, sitoplasma eosinofilik. Stroma terdiri dari jaringan fibrous yang diinfiltrasi oleh sel-sel tumor dan sebukan sel-sel radang polimorfonuklear yang masif. Sel-sel tumor tampak telah menyusup di antara lapisan muskularis. Pembuluh darah proliferatif, sebagian dilatasi dan kongesti. Hasil pemeriksaan histopatologi menunjukkan gambaran yang sesuai dengan karakteristik adenokarsinoma kolon Kata kunci. Adenokarsinoma kolon, adenokarsinoma, kolon
Gambaran dislipidemia pada pasien stroke akut di RSUD Arifin Achmad Provinsi Riau Periode Januari-Desember 2019
Authors: Nugraha Dimas Pramita , Bebasari Eka , Sahputra Sahwal
Published: June 2022

Stroke is a disease of the brain functional disorders that arises suddenly and lasts more than 24 hours or ends in death situation without a known cause other than vascular disorders. Strokes are generally classified into ischemic stroke (non-hemorrhagic) and hemorrhagic stroke, One of the risk factors of stroke is dyslipidemia. The aim of this study was to describe dyslipidemia in acute stroke patients at Arifin Achmad Regioal General Hospital of Riau Province in January to December 2019. This was a descriptive study design with cross sectional study method by using secondary data of the acute stroke patient's medical record at Arifin Achmad Regional General Hospital of Riau Province in January to December 2019 with a total sample of 103 cases. The results show that stroke is more common in male that is 63 (61.2%) cases, and the majority happened within the 51-65 years age groups with 54 (52.4%) cases. Most of the stroke’s type in patients were hemorrhagic stroke in 59 (57.3%) cases. Highest total of cholesterol level remains normal in 46 (44.7%) cases. The majority of patients still presented with normal level of High Density Lipoprotein (HDL) in 49 (47.6%) cases. In contrary, most patients presented with high level of Low Density Lipoprotein (LDL) in 26 (25.2%) cases and also with normal level but considered as high-risk group in  26 (25.2%) cases. Most patients still presented with normal level of triglyceride in 65 (63.1%) cases. There were 17 (16.5%) cases of patient with dyslipidemia, 9 of them were considered as ischemic stroke (52.9%). The conclusion of this study is that dyslipidemia commonly occurs in ischemic stroke types compared to a hemorrhagic stroke. Keywords: dyslipidemia, stroke, non hemorrhagic stroke
Hubungan antara pengetahuan tentang gizi dengan kebiasaan sarapan pada mahasiswa
Authors: Aulia Dara Tsuraiya , Yusni Yusni , Husnah Husnah , Nauval Iflan , Suryawati Suryawati
Published: June 2022

Mahasiswa tergolong usia dewasa yang diharuskan dapat menerapkan pengetahuan yang dimilikinya dalam kehidupan sehari-hari. Prevalensi kebiasaan jarang sarapan pada mahasiswa lebih banyak daripada yang memiliki kebiasaan sarapan yang baik. Jenis penelitian adalah analitik observasional dengan desain cross sectional. Sampel diambil secara total sampling dengan jumlah responden sebanyak 133 mahasiswa Fakultas Keperawataan Universitas Syiah Kuala tahun angkatan 2017, namun hanya 80 responden yang masuk kriteria inklusi. Pengetahuan gizi dinilai menggunakan kuesioner dan kebiasaan sarapan dinilai menggunakan Food Frequency Questionnaire (FFQ). Hasil penelitian menunjukkan dari 58 mahasiswa yang memiliki pengetahuan gizi baik, sebanyak 47 mahasiswa (81%) memiliki kebiasaan sarapan yang baik. Sedangkan dari 22 mahasiswa yang memiliki pengetahuan gizi kurang, sebanyak 12 mahasiswa (54,5%) memiliki kebiasaan sarapan yang kurang. Hasil analisis uji chi-square­, nilai P value 0,002 (P value 0,05), PR 1,783 (PR  1) artinya semakin baik pengetahuan gizi mahasiswa semakin baik kebiasaan sarapan sehingga terdapat hubungan antara pengetahuan gizi dengan kebiasaan sarapan pada mahasiswa Fakultas Keperawatan Universitas Syiah Kuala tahun angkatan 2017.
Very Severe Hypertriglyceridemia in Children with Diabetic Ketoacidosis
Authors: Sari Tiara Ella , Rini Eka Agustia , Khairunnisa Khairunnisa
Published: June 2022

Background: Hypertriglyceridemia can be observed in up to 50% of patients with diabetic ketoacidosis (DKA), but a condition for DKA with very severe hypertriglyceridemia is uncommon. The objective of this case report is to present and describe the clinical features, laboratory investigations, case management, and natural course of hypertriglyceridemia in DKACase summary: A 9-year-old girl referred by district hospital with DKA and hypertriglyceridemia. Chief complaint was a decreased in consciousness for 16 hours before the admission. Patient has been known to suffer from  diabetes mellitus within  these 9 months. At ER patient looked severely ill, GCS 7, Kussmaul breathing. Random blood glucose was 255 mg/dL. Glycosuria and ketone urine tests were positive. Triglyceride level was 16.200 mg/dL. She had diagnosed with diabetic encephalopathy, DKA and very severe hypertriglyceridemia due to DKA. We treat DKA with standard guidelines, and on the 15th day we gave additional therapy fibrates and omega oil to treat the very severe hypertriglyceridemia. The level of triglyceride decreased gradually with hydration and insulin in standard guideline for DKA but didn’t achieve the normal level. With additional treatment, normal level of triglyceride achieved without any clinical side effects.Conclusion: Triglyceride level should be monitored in DKA patients. The hypertriglyceridemia can be treated by hydration, insulin, fibrates, and omega oil. The use of these treatment need to be evaluated for side effects.
Pasien Spinocerebellar Ataxia 3 (SCA3) dengan neuropati perifer di Indonesia : laporan kasus
Authors: Pusparini Iin
Published: June 2022

Abstract Rationale: Spinocerebellar ataxia (SCA) 3, also known as Machado-Joseph Disease (MJD), is a neurodegenerative disease which involves cerebellum and its afferent and efferent pathways. Generally, the initial symptoms were gait disturbance, double vision, dysarthria, and vertigo.Patient concerns: a 43-year-old male, with known SCA3, presented hereditary ataxia had mild numbness in his both palms since two years ago. Sensory examination found no abnormality. Nerve Conduction Studies (NCS) showed severe axonal demyelinating sensorimotor peripheral neuropathy. In magnetic resonance imaging atrophy cerebellum with cerebral multiple lacunar infarction were seen. Diagnoses: SCA3 was diagnosed on the basis of clinical features, family pedigree, physical examination, electrophysiology study, neuroimaging, nerve biopsy, and genetic testing results. The electrophysiological manifestations revealed profound axonal demyelinating lesion in peripheral nerves. Genetic analysis was not done yet due to lack of availability of genetic testing in our country at this moment although it is the gold standard for diagnosis.Lessons: SCA3 with peripheral neuropathy represents a specific clinical entity that so far has never been described previously in Indonesia.Abbreviations: SCA3 = Spinocerebellar ataxia, MJD = Machado-Joseph Disease, NCS = Nerve Conduction Studies
Gambaran tingkat kepatuhan penggunaan obat antihipertensi pada penderita hipertensi di puskesmas pante raya kabupaten Bener Meriah periode bulan Agustus 2020
Authors: Otawa Chesy Oety , Hasballah Kartini , Kamarlis Reno Keumalazia
Published: June 2022

Hipertensi merupakan keadaan meningkatnya tekanan kapiler darah akibat terjadi konstriksi pada pembuluh darah. Pada penanganan hipertensi perlu menggunakan obat antihipertensi yang akan efektif jika dengan meminumnya sesuai anjuran tenaga kesehatan, Berdasarkan alasan tersebut, peneliti bermaksud untuk mengetahui tingkat kepatuhan penggunaan obat antihipertensi pada penderita hipertensi di Puskesmas Pante Raya periode Bulan Agustus 2020. Penelitian ini menggunakan survei deskriptif observational dengan pendekatan cross sectional. Sampel yang digunakan pada penelitian ini adalah seluruh pasien yang telah didiagnosis hipertensi di Puskesmas Pante Raya Kabupaten Bener Meriah yang memenuhi kriteria pada periode Agustus 2020 dan diambil dengan teknik consecutive sampling. Responden berjumlah 49 orang dengan jumlah populasi 62 orang. Instrumen yang digunakan adalah kuesioner Morisky Medication Adherence Scale (MMAS-8). Hasil yang didapatkan pada penelitian ini adalah tingkat kepatuhan penderita hipertensi di Puskesmas Pante Raya periode Agustus rendah, dengan mencapai persentase 100%. Penderita hipertensi banyak diderita oleh usia 56-65 tahun sebanyak (46,9%) dengan jumlah wanita (79,6%) lebih banyak dibandingkan laki-laki (20,4%). pendidikan terakhir responden terbanyak adalah tingkat SMA/sederajat (42,9%) sedangkan responden yang bekerja (65,3%)  lebih banyak daripada yang tidak bekerja (65,3%). Maka dapat disimpulkan bahwa tingkat kepatuhan penggunaan obat antihipertensi pada Puskesmas Pante Raya periode bulan Agustus 2020 adalah rendah.
HUBUNGAN TINGKAT STRES TERHADAP SMARTPHONE ADDICTION PADA MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS PEMBANGUNAN NASIONAL VETERAN JAKARTA TAHUN 2020
Authors: Alfitachiyyah Alfitachiyyah
Published: June 2022

Pada tahun 2020, World Health Organization (WHO) menetapkan Corona Virus Disease 19 atau Covid-19 sebagai pandemi global dan menghimbau untuk melakukan metode Pembelajaran Jarak Jauh (PJJ). Perubahan yang terjadi pada mahasiswa akibat Covid-19 tentunya berdampak pada psikologis mahasiswa, salah satunya adalah stres. Seseorang yang sedang mengalami situasi atau keadaan yang menimbulkan stres, akan berusaha secara alamiah untuk mengatasinya dengan menggunakan sejumlah perilaku tertentu, salah satunya adalah dengan menggunakan smartphone. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara tingkat stres terhadap smartphone addiction pada mahasiswa. Nilai tingkat stress didapatkan dengan Perceived Stress Scale – 10 dan nilai smartphone addiction didapatkan dengan SAS-Short Version yang sudah dimodifikasi. Desain penelitian yang digunakan adalah potong lintang. Jumlah sampel pada penelitian ini sebanyak 185 orang yang memenuhi kriteria inklusi. Hasil penelitian ini tidak terdapat hubungan (p = 0,364) antara tingkat stres dengan smartphone addiction. Hal ini disebabkan mahasiswa menggunakan smartphone dalam melakukan pembelajaran jarak jauh, perubahan proses pembelajaran tersebut menyebabkan tingginya penggunaan smartphone yang dialami oleh mahasiswa
Hubungan kemampuan visuospasial dengan kemampuan anatomi
Authors: Nurizzan M. Ghilman
Published: June 2022

Along with the development of medical learning methods, anatomy remains one of the most difficult subjects to understand among other basic medical education sciences. The study of the structure of the human body, its parts and the relationships between these parts involves the processing of visuospatial information, namely the understanding of the form, location, and position of an object against other objects in 3-dimensional space. The purpose of this research is to find out how the relationship between visuospatial abilities and anatomical abilities of the students of the Faculty of Medicine, Sebelas Maret University
Profil Ketuban Pecah Dini pada Ibu Bersalin di RSUD Dr. Zainoel Abidin Banda Aceh
Authors: Novirianthy Rima , Safarianti Safarianti , Syukri Maimun , Yeni Cut Meurah , Arzda Muhammad Ikhsan
Published: June 2022

Abstrak. Angka Kematian Ibu (AKI) merupakan salah satu indikator keberhasilan suatu negara dalam bidang kesehatan. Salah satu penyebab kematian pada ibu adalah infeksi. Ketuban Pecah Dini (KPD) merupakan salah satu penyebab tersering infeksi. Tujuan dari penelitian ini yaitu untuk mengetahui profil KPD pada ibu bersalin di RSUDZA Banda Aceh tahun 2019-2020. Metode penelitian ini berupa penelitian deskriptif dengan menggunakan data retrospektif. Jumlah sampel yang digunakan dalam penelitian ini sebanyak 579 rekam medis pasien yang diambil dengan metode total sampling. Analisis data yang digunakan ialah analisis univariat untuk melihat profil pasien KPD. Hasil penelitian menunjukkan bahwa dari 579 sampel pasien KPD sebagian besar sampel berusia 20-35 tahun (79,3%), status pekerjaan sebagai IRT (81,3%), usia kehamilan aterm (77,2%), status nullipara (36,8%), mengalami leukosituria (52,9%), anemia (54,9%), kehamilan tunggal (98,4%), janin presentasi kepala (89,8%), lama KPD ≥ 12 jam (53,9%), dan metode persalinan sectio caesarea (66%). Kesimpulan penelitian ini menunjukkan bahwa KPD banyak terjadi pada ibu nullipara yang berusia 20-35 tahun dengan usia kehamilan aterm serta mengalami leukosituria dan anemia, oleh karena itu tenaga medis perlu memberikan edukasi terkait faktor risiko dan upaya pencegahan KPD. Kata Kunci : Ketuban Pecah Dini (KPD), Profil, RSUDZA Banda  AcehAbstract. Maternal Mortality Rate (MMR) is acknowledge as one of the country’s health sector development. Infection is one of the cause of maternal mortality. Premature Rupture of Membranes (PROM) is the most cause of infection. The objective of this research is to identify the profile of premature rupture of membranes on mother who gave birth in RSUDZA Banda Aceh year of 2019-2020. The method of this research is descriptive using retrospective data. The number of samples used in research is 579 medical records taken using total sampling method. Data analysis used is univariate analysis to find the profile of premature rupture of membrane patient. The result showed that out of 579 samples of patient with premature rupture of membrane are mostly aged between 20-35 years old (79,3%), occuption status as housewife (81,3%), gestation age of aterm (77,2%), nulliparous status (36,8%), leukocyturia (52,9%), anemia (54,9%), single preganancy (98,4%), fetal head presentation (89,9%), PROM duration ≥ 12 hours (53,9%), and the method delivery by sectio caesarea (66%). The conclusion of thin study showed that PROM occurs mostly in nulliparous who are 20-35 years old with aterm gestational age and have leukocyturia and anemia; therefore, medical personnel need provide education related risk factor and efforts to prevent PROM.Keywords : Premature Rupture of Membranes (PROM), Profile, RSUDZA Banda Aceh
KETERLAMBATAN DETEKSI DINI PADA CONJOINED TWIN
Authors: Sarjani Sarjani , Dewi Teungku Puspa
Published: June 2022

ABSTRAKPendahuluan: Kembar siam mengacu pada kembar yang secara fisik menyatu dalam rahim dan akibatnya saat lahir. Penyebutan pertama kembar siam secara historis berasal dari periode neolitik. Jenis kehamilan ini adalah fenomena rumit yang memerlukan pendekatan interprofesional untuk mengelolanya secara efektif. Objek:Laporan kasus ini bertujuan untuk menjelaskan mengenai pentingnya deteksi dini konjoin twin. Metode : Studi ini merupakan studi prospektif menggunakan metode pendekatan sehingga dapat mencapai diagnosis terbaik. Evaluasi obstetri dengan berbagai pemeriksaan diagnostik dilakukan untuk mengetahui kondisi kedua janin.
Karakteritik Pasien Ginekologi di RSU Cut Meutia Aceh Utara Selama Pandemi Covid-19 Tahun 2020
Authors: Iskandar Iskandar -
Published: June 2022

Gynaecology literally means "the science of women" or science of woman, which is a branch of medical science that specifically studies and treats diseases of the female reproductive system. The scope of gynecology includes, among others, menstrual disorders and AUB, infectious diseases, tumors, post-treatment and so on. Uterine fibroids are the most common benign tumor found with a worldwide incidence of 20–35%.  This research is a descriptive study with the research design used is across-sectional studyconducted in the Gynecology Inpatient Room at the Cut Meutia Hospital, North Aceh. The study was conducted in June 2021 with a population and sample of all patients in the Gynecological Inpatient Room at the Cut Meutia Hospital North Aceh in 2020. The variables of this study were types of gynecological diseases which were divided into menstrual disorders, infections, benign tumors, malignant tumors and so on. Univariate analysis was used to describe the characteristics of the types of gynecological diseases that existed in the Gynecological Inpatient Room at the Cut Meutia Hospital North Aceh in 2020. The patients who were treated in the Gynecological Inpatient Room at the Cut Meutia North Aceh Hospital in 2020 were 70 patients who were divided into groups of menstruation disorders and AUB, infectious diseases, tumors and so on. The percentage of benign and post-operative tumors is the largest group of diseases, while infections and malignant tumors are the least. Uterine fibroids are the most common disease, followed by menstrual disorders (AUB), uterine prolapse, ovarian cysts and endometrial hyperplasia.
PUASA RAMADHAN DAN PENGARUHNYA TERHADAP PROGRESIFITAS PENYAKIT GINJAL KRONIK
Authors: Abdullah Abdullah , Salwani Desi , Muhsin Muhsin , Khairi Andri Baftahul , Syukri Maimun
Published: June 2022

Bulan Ramadhan merupakan bulan suci umat Islam dimana pada bulan ini seluruh umat Islam diwajibkan untuk berpuasa selama satu bulan penuh, mulai dari terbit fajar hingga tenggelam matahari. Pengaruh puasa Ramadhan terhadap fisiologis dan biokimia tubuh telah banyak dipelajari dengan hasil yang berbeda-beda. Banyak penelitian menunjukkan puasa Ramadhan dapat ditoleransi dengan aman pada orang sehat dan memberikan efek yang menguntungkan dalam hal regulasi tekanan darah, kadar lipid darah, stres oksidatif, sensitivitas insulin, dan penyakit jantung kronis jika dilakukan dengan benar. Ada banyak kontroversi mengenai puasa Ramadhan untuk penderita Penyakit Ginjal Kronik (PGK) terutama apakah puasa tersebut memperbaiki indikator fungsi ginjal atau malah sebaliknya. Terdapat juga banyak kekhawatiran tentang dampak dehidrasi dan efek hipoperfusi ginjal selama puasa Ramadhan terhadap penderita PGK. Tinjauan kepustakaan ini memberikan bukti-bukti terbaru tentang pengaruh puasa Ramadhan terhadap progresifitas PGK, baik pada penderita predialisis, yang sedang menjalani dialisis, maupun yang telah menjalani transplantasi ginjal.
Hubungan tingkat pengetahuan dengan sikap terhadap imunisasi vaksin Human Papilloma Virus sebagai pencegahan primer kanker serviks pada mahasiswi fakultas keperawatan Unsyiah
Authors: Mulia Vera Dewi , Latifa Nurrahmah , Amirsyah Mirfandi , Novia Hijra Suardi
Published: June 2022

Abstrak. Kanker serviks merupakan silent killer disease dengan penderita risiko tinggi pada perempuan mulai umur 20 tahun. Human Papilloma Virus (HPV) adalah penyebab terjadinya kanker serviks. Kanker serviks dapat dicegah secara efektif dengan vaksinasi HPV. Penelitian ini bertujuan untuk mengetahui hubungan antara tingkat pengetahuan dengan sikap terhadap imunisasi vaksin HPV sebagai pencegahan primer kanker serviks pada Mahasiswi Fakultas Keperawatan Unsyiah. Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional. Sampel penelitian adalah 82 Mahasiswi Fakultas Keperawatan Unsyiah. Pemilihan sampel menggunakan teknik proportional random sampling. Pengambilan data dilakukan dengan mengisi kuisioner online (google form). Uji hipotesis yang digunakan adalah fisher exact test. Hasil penelitian menunjukkan bahwa sebanyak 41 Mahasiswi (50.0%) memiliki tingkat pengetahuan baik dan sikap positif terhadap imunisasi vaksin HPV sebanyak 78 Mahasiswi (95.1%). Hasil uji statistik fisher exact test diperoleh p-value sebesar 0.000 (p 0.05), sehingga H0 ditolak. Kesimpulan yang diperoleh adalah terdapat hubungan tingkat pengetahuan dengan sikap terhadap imunisasi vaksin HPV sebagai pencegahan primer kanker serviks pada Mahasiswi Fakultas Keperawatan Unsyiah. Kata kunci: Pengetahuan, sikap, imunisasi vaksin HPV, mahasiswi Abstract. Cervical cancer is the silent killer disease with high risk patients in women starting at 20 years old. Human Papilloma Virus (HPV) is known as precursor of cervical cancer. Cervical cancer can be prevented effectively by practicing HPV vaccine. The purpose of this study was to determine the relationship between knowledge and attitude toward HPV vaccination as primary prevention of cervical cancer for student in Nursing Faculty of Syiah Kuala University. This research is an observational analytic study with cross sectional design. The sample of this research are students in Nursing Faculty of Syiah Kuala University with the quantity of 82 students taken by using proportional random smapling technique. The data was collected by filling out an online questionnaire (google form). The hypothesis in this study was analyzed by fisher exact test. The results showed that there was 41 college student (50.0%) had a good of knowledge and positive attitude about HPV vaccination there was 78 college students (95.1%). Fisher exact test statistic test result obtained p-value was 0.000 (p 0.05), so H0 was rejected. The conclusion is there was a relationship between knowledge and attitude toward HPV vaccination as primary prevention of cervical cancer for students in Nursing Faculty of Syiah Kuala University. Keywords: Knowledge, attitude, HPV vaccination immunization, college student
Gambaran Tingkat Pengetahuan, Sikap dan Tindakan terhadap COVID-19 pada Mahasiswa Sarjana Kedokteran dan Profesi Dokter Angkatan 2018-2019 Fakultas Kedokteran Universitas Udayana
Authors: Rompis Andreliano Yosua , Sandra Sandra , Wulandari Putri Ayu , Dewi Ni Nyoman Ayu
Published: June 2022

Mahasiswa kedokteran merupakan garda terdepan dalam menghadapi masalah kesehatan, khususnya pencegahan COVID-19. Tingkat pengetahuan, sikap, dan tindakan yang baik pada mahasiswa kedokteran dapat turut serta mencegah penularan COVID-19 di masyarakat. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan, sikap, dan tindakan mahasiswa sarjana kedokteran dan profesi dokter Universitas Udayana terhadap COVID-19. Desain penelitian yang digunakan adalah potong lintang dengan non-probability sampling consecutive sampling. Pengambilan data menggunakan kuesioner secara daring dalam bentuk google form. Penelitian dilakukan pada bulan Agustus – September 2020 dengan jumlah responden sebanyak 224 responden. Hasil penelitian menunjukkan tingkat pengetahuan responden seluruhnya baik (100%). Sikap dan tindakan responden menunjukkan hasil yang positif dengan selalu mengikuti perkembangan informasi COVID-19 (100%) dan mengikuti protokol kesehatan (97,8%). Hasil penelitian menunjukkan tidak terdapat perbedaan rerata skor pengetahuan, sikap dan tindakan terhadap masing-masing kategori karakteristik responden, namun terdapat perbedaan rerata skor sikap antara responden yangt tinggal di kota dan desa. Sebagai simpulan, mayoritas responden menunjukkan tingkat pengetahuan, sikap, dan tindakan yang baik. Walaupun begitu, mahasiswa kedokteran tetap disarankan untuk terus meningkatkan pengetahuan, sikap, dan tindakan terhadap COVID-19 khususnya pada isu-isu kontroversial COVID-19.
Escasez de agua, disponibilidad y agricultura
Authors:   Instituto Mexicano de Tecnología del Agua - IMTA, Pedrozo Acuña Adrián
Published: June 2022

La escasez del agua es reconocida como una de las amenazas más críticas para el correcto funcionamiento de la sociedad y la supervivencia de los ecosistemas acuáticos.
Effectiveness of mesoporous bioglass in drug delivery
Authors:   Department of Biomedical, Industrial and Human Factors Engineering, Wright State University, Dayton, OH 45435, USA, Galbreath Sheila , Krueger Bailey ,   Department of Biomedical, Industrial and Human Factors Engineering, Wright State University, Dayton, OH 45435, USA, Frazier Taylor ,   Department of Biomedical, Industrial and Human Factors Engineering, Wright State University, Dayton, OH 45435, USA, Goswami Tarun ,   Department of Biomedical, Industrial and Human Factors Engineering, Wright State University, Dayton, OH 45435, USA
Published: June 2022

Since the invention of bioactive glass 50 years ago, it has become a versatile material used in healthcare in a variety of applications and compositions. Bioactive glass has shown superior capabilities of drug delivery compared to traditional carriers. For example, time-released medications are less likely to reach toxic levels, while delivering a specific, therapeutic dose to a localized area. The objective of this paper is to investigate the properties and effectiveness of mesoporous bioglass (MBG) as a drug delivery carrier. A literature review of various polymer coated 45S5 Bioglass® loaded with vancomycin was analyzed to determine their drug release response. Since MBG continues to be a preferred carrier with numerous combinations; size, coating, doped with ions, medications, and other physical conditions, there is a need to understand more fully their effectiveness. For a given loading efficiency of 5-15% the burst release % for day 1 remained 15-30% for given surface area, pore volume and pore size of 3.5 to 5 nm. The mechanical properties summarized in this paper are compared with the drug release kinetics. In general, for a given fracture toughness and compressive strength, the ratio of Young’s modulus to bending strength around 250 determined poor apatite mineralization resulting in slow release. As this ratio increased the apatite mineralization and dissolution rate increased. Doping MBG with ions enhanced the drug efficacy to treat a particular condition, for example, silver. Polymer coated MBG exhibited slower dissolution rate than uncoated MBG. Dissolution time increased with the drug loading rate, drying time of the coating, multi-layer coats of drug and polymer for the drug studied in this paper to more than 50%.
Electrochemical Studies on Manganese (III) Complex with meso-5, 10, 15, 20-Tetrakis (o-nitrophenyl) porphyrin by Cyclic Voltammetry and UV-Visible Spectrophotometry
Authors: Thandiayyakone V. , Murugan A. , Ravikumar C.R. , Rajkumar T. , Yadav H.S.
Published: June 2022

Meso-5,10,15,20-Tetrakis(o-nitrophenyl)porphyrin, [T (o-NO2)PP] and manganese (III) meso-5,10,15,20- Tetrakis(2,5-dimethoxyphenyl)porphyrin, Mn[T(o- NO2)PP] have been prepared. The Mn[T(o-NO2)PP] complex is characterized by UV-Vis spectrophotometric and cyclic voltametric (CV) studies. The preparation of Mn(III) porphyrin complex may be attributed due to a significant metal-porphyrin π interaction. In Mn(III) porphyrin, Mn is in a high spin d4 configuration with octahedral geometry. Mn(III) porphyrin geometry has been altered to square pyramidal Mn(II) porphyrin after addition of ethylamine. In square pyramidal Mn(II) porphyrin, Mn atom is in a high-spin d5 configuration with the occupied d(x 2 - y 2 ) orbital whose orbital energy is low. This shows that Mn(III) will be out of the plane of porphyrin. Successive addition of diethylamine, Mn(III) porphyrin geometry has been changed to tetragonal complex due to a weak π back bonding. It appears that π -bonding is lowered when the tetragonal complexes are formed. This might arise due to the expansion of the in-plane metal to porphyrin in a direction to occupy two axial ligands of ethylamine. The geometry changes indicate that the two ethyl amines groups occupy 5th and 6th places as axial coordination site due to the availability of two ethylamine from ethyl, diethyl and triethyl amines. Cyclic voltammogram confirmed the oxidation state and reduction behavior of Mn porphyrin complex.
Divalent benzimidazolium-based axles for self-reporting pseudorotaxanes
Authors: Taimoory S. Maryamdokht , Yu Xiao , Beyeh N. Kodiah , Trant John F.
Published: June 2022

Mono and (bis)benzimidazoliums were evaluated both experimentally and computationally for their potential as pseudopolyrotaxane axle building blocks. Their aggregation and photophysical behavior, along with their potential to form a [2]pseudorotaxane with dibenzyl-24-crown-8, was studied through the synergistic application of 1D/2D and diffusion ordered NMR spectroscopy, mass spectrometry, ultraviolet-visible & fluorescence spectroscopy, and time-dependent density functional theory. Their photophysical behaviour was measured and modeled as a function of protonation state, solvent, and concentration. The axles show strong solvochromaticism and a very pronounced concentration-dependent optical profile, including self-quenching when a pseudorotaxane is formed. This axle with multiple recognition sites, has the potential to form pseudorotaxanes with tunable optical behavior.
Effect of uncertainty in sorbent characteristic on techno-economic feasibility of carbonate looping for decarbonisation of coal-fired power plant
Authors: Hanak Dawid
Published: June 2022

Carbon capture, utilisation and storage technologies are forecasted to significantly contribute to the decarbonisation of the power sector. Chemical solvent scrubbing is now considered the most mature carbon capture, utilisation and storage technology. Yet, its integration with fossil fuel power plants is forecasted to reduce the net efficiency of the entire process by at least 7% points, resulting in the avoided CO2 cost of 35–75 €/tCO2. Carbonate looping has been demonstrated to be an emerging technology for decarbonisation of the power sector with lower efficiency (>5% points) and economic penalties (10–30 €/tCO2). The key challenge that may influence the viability of carbonate looping is the decay in the sorbent CO2 uptake. Such a deterioration in sorbent performance is usually accounted for in the techno-economic assessments via semi-empirical correlations. Yet, such correlations include fitting parameters based on experimental data that is, in turn, associated with ±20% measurement error. This study employed a stochastic approach to quantify the impact of such uncertainty in the sorbent characteristics on the techno-economic performance of a 580 MWel coal-fired power plant with carbonate looping retrofit. The stochastic assessment showed that the most likely figures for the efficiency penalty would fall between 7.7% points and 8.7% points, with a median of 8.08% points. Such a figure was higher than the one determined using the deterministic approach (7.85% points). Moreover, the estimated CO2 avoided cost was between 29.74 €/tCO2 and 46.50 €/tCO2, with a median of 35.94 €/tCO2. Such a figure was higher than that obtained in the deterministic assessment (32.40 €/tCO2). It implied that the economic assessment using the deterministic approach could underestimate the costs associated with the carbonate looping retrofits. This study, therefore, revealed that the uncertainty in the sorbent characteristics would influence the techno-economic viability of the carbonate looping retrofits.
Conical intersections in solution with polarizable embedding: Integral-exact direct reaction field
Authors: Liu Xiao , Humeniuk Alexander , Glover William
Published: June 2022

A common strategy to exploring the properties and reactivity of complex systems is to use quantum mechanics/molecular mechanics (QM/MM) embedding, wherein a QM region is defined and treated with electronic structure theory and the remainder of the system is treated with a forcefield. Of equal importance to the level of quantum chemical theory used for the QM region and the quality of the forcefield is the treatment of the coupling between the QM and MM subsystems. The state-of-the-art is to use a polarizable forcefield for the MM region and mutually couple the QM wavefunction and MM induced dipoles, in addition to the usual electrostatic embedding, yielding a polarizable embedding (QM/MM-Pol) approach. However, extensions to electronic excited states are less well developed, and we showed previously that current popular QM/MM-Pol approaches exhibit issues of root flipping and/or incorrect descriptions of electronic crossings in multistate calculations.[J. Chem. Theory Comput. 14, 2137 (2018)] Here we demonstrate a solution to these problems with an integral-exact reformulation of the Direct Reaction Field approach of Thole and Van Duijnen (QM/MM-IEDRF). The resulting embedding potential includes one- and two-electron operators, and many-body dipole-induced dipole interactions, and thus includes a natural description of the screening of electron-electron interactions by the MM induced dipoles. Pauli repulsion from the environment is mimicked by effective core potentials on the MM atoms. Inherent to the DRF approach is the assumption that MM dipoles respond instantaneously to the positions of the QM electrons, therefore dispersion interactions are captured approximately. All electronic states are eigenfunctions of the same Hamiltonian while the polarization induced in the environment and the associated energetic stabilization are unique to each state. This allows for a consistent definition of transition properties and state crossings. We demonstrate QM/MM-IEDRF by exploring the influence of a (polarizable) inert xenon matrix environment on the conical intersection underlying cis-trans isomerization of ethylene.
Reply to Comment on “Molecules, the Ultimate Nanomotor: Linking Chemical Reaction Intermediates to their Molecular Diffusivity”
Authors: Huang Tian , Li Bo , Wang Huan , Granick Steve
Published: June 2022

Several studies by our group suggest enhanced mobility of certain molecules during some (not all) chemical reactions. This is likely the result of multiple factors including possibly that chemical reaction dynamically changes the hydration or solvation layer. Beves, Fischer and coworkers challenge this view with arguments that the diffusion NMR methods we used to detect molecular diffusion are faulty. Here, using the shuffled magnetic field gradient sequence method of diffusion NMR recommended by Beves, Fischer and coworkers, and considering the CuAAC click reaction that they criticize specifically, we provide new data and analysis that validates our earlier conclusions. Analysis of NMR spectra and of survey of the literature validates that our study detected chemical reaction intermediates (not the H-D exchange proposed by Beves, Fischer and coworkers). We endeavor to reconcile opposing arguments of this debate.