bluuebunny/crossref_metadata_2025 huggingface dataset:
Generic Entanglement Entropy for Quantum States with Symmetry
Authors: Nakata Yoshifumi , Murao Mio
Published: June 2020

When a quantum pure state is drawn uniformly at random from a Hilbert space, the state is typically highly entangled. This property of a random state is known as generic entanglement of quantum states and has been long investigated from many perspectives, ranging from the black hole science to quantum information science. In this paper, we address the question of how symmetry of quantum states changes the properties of generic entanglement. More specifically, we study bipartite entanglement entropy of a quantum state that is drawn uniformly at random from an invariant subspace of a given symmetry. We first extend the well-known concentration formula to the one applicable to any subspace and then show that 1. quantum states in the subspaces associated with an axial symmetry are still highly entangled, though it is less than that of the quantum states without symmetry, 2. quantum states associated with the permutation symmetry are significantly less entangled, and 3. quantum states with translation symmetry are as entangled as the generic one. We also numerically investigate the phase-transition behavior of the distribution of generic entanglement, which indicates that the phase transition seems to still exist even when random states have symmetry.
Groupwise Non-Rigid Registration with Deep Learning: An Affordable Solution Applied to 2D Cardiac Cine MRI Reconstruction
Authors: Martín-González Elena , Sevilla Teresa , Revilla-Orodea Ana , Casaseca-de-la-Higuera Pablo , Alberola-López Carlos
Published: June 2020

Groupwise image (GW) registration is customarily used for subsequent processing in medical imaging. However, it is computationally expensive due to repeated calculation of transformations and gradients. In this paper, we propose a deep learning (DL) architecture that achieves GW elastic registration of a 2D dynamic sequence on an affordable average GPU. Our solution, referred to as dGW, is a simplified version of the well-known U-net. In our GW solution, the image that the other images are registered to, referred to in the paper as template image, is iteratively obtained together with the registered images. Design and evaluation have been carried out using 2D cine cardiac MR slices from 2 databases respectively consisting of 89 and 41 subjects. The first database was used for training and validation with 66.6–33.3% split. The second one was used for validation (50%) and testing (50%). Additional network hyperparameters, which are—in essence—those that control the transformation smoothness degree, are obtained by means of a forward selection procedure. Our results show a 9-fold runtime reduction with respect to an optimization-based implementation; in addition, making use of the well-known structural similarity (SSIM) index we have obtained significative differences with dGW with respect to an alternative DL solution based on Voxelmorph.
Ultra-Low-Voltage Inverter-Based Amplifier with Novel Common-Mode Stabilization Loop
Authors: Manfredini Giuseppe , Catania Alessandro , Benvenuti Lorenzo , Cicalini Mattia , Piotto Massimo , Bruschi Paolo
Published: June 2020

This work presents a single-stage, inverter-based, pseudo-differential amplifier that can work with ultra-low supply voltages. A novel common-mode stabilization loop allows proper differential operations, without impacting over the output differential performance. Electrical simulations show the effectiveness of this amplifier for supply voltages in the range of 0.3–0.5 V. In particular, a dc voltage gain of 25.16 dB, a gain-bandwidth product of 131.9 kHz with a capacitive load of 10 pF, and a static current consumption of only 557 nA are estimated at VDD = 0.5 V. Moreover, the circuit behavior with respect to process and temperature variations was verified. Finally, the proposed amplifier is employed in a switched-capacitor integrator and in a sample-and-hold circuit to prove its functionality in case-study applications.
Test Solution for Heatsinks in Power Electronics Applications
Authors: Piumatti Davide , Borlo Stefano , Quitadamo Matteo , Sonza Reorda Matteo , Giacomo Armando Eric , Fiori Franco
Published: June 2020

Power electronics technology is widely used in several areas, such as in the railways, automotive, electric vehicles, and renewable energy sectors. Some of these applications are safety critical, e.g., in the automotive domain. The heat produced by power devices must be efficiently dissipated to allow them to work within their operational thermal limits. Moreover, numerous ageing effects are due to thermal stress, which causes mechanical issues. Therefore, the reliability of a circuit depends on its dissipation system, even if it consists of a simple passive heatsink mounted on the power device. During the Printed Circuit Board (PCB) production, an incorrect assembly of the heatsink can cause a worse heat dissipation with a significant increase of the junction temperatures (Tj). In this paper, three possible test strategies are compared for testing the correct assembling of heatsinks. The considered strategies are used at the PCB end-manufacturing. The effectiveness of the different test methods considered is assessed on a case study corresponding to a Power Supply Unit (PSU).
Triple Solutions of Carreau Thin Film Flow with Thermocapillarity and Injection on an Unsteady Stretching Sheet
Authors: Naganthran Kohilavani , Hashim Ishak , Nazar Roslinda
Published: June 2020

Thin films and coatings which have a high demand in a variety of industries—such as manufacturing, optics, and photonics—need regular improvement to sustain industrial productivity. Thus, the present work examined the problem of the Carreau thin film flow and heat transfer with the influence of thermocapillarity over an unsteady stretching sheet, numerically. The sheet is permeable, and there is an injection effect at the surface of the stretching sheet. The similarity transformation reduced the partial differential equations into a system of ordinary differential equations which is then solved numerically by the MATLAB boundary value problem solver bvp4c. The more substantial effect of injection was found to be the reduction of the film thickness at the free surface and development of a better rate of convective heat transfer. However, the increment in the thermocapillarity number thickens the film, reduces the drag force, and weakens the rate of heat transfer past the stretching sheet. The triple solutions are identified when the governing parameters vary, but two of the solutions gave negative film thickness. Detecting solutions with the most negative film thickness is essential because it implies the interruption in the laminar flow over the stretching sheet, which then affects the thin film growing process.
Cooling Performance Optimization of Direct Dry Cooling System Based on Partition Adjustment of Axial Flow Fans
Authors: Huang Wenhui , Chen Lei , Wang Weijia , Yang Lijun , Du Xiaoze
Published: June 2020

Axial flow fans play key roles in the thermo-flow performance of direct dry cooling system under windy conditions, so the energy efficiency of a power generating unit can be improved by optimizing the operation strategies of the axial flow fans. In this work, various measures based on the partition adjustment of axial flow fans with constant power consumption of a 2 × 660 MW power plant are studied by computational fluid dynamics (CFD) methods. The results show that increasing the rotational speed of the windward fans is beneficial to reduce the inlet air temperature and increase the mass flow rates of the fans, which enhance the heat rejections of the air-cooled condensers, especially at high wind speeds. Moreover, the turbine back pressures for the optimal and original cases are achieved by iterative methods, with the largest drop of 2.77 kPa at the wind speed of 12 m/s for 110-case 3 in the wind direction of −90°. It is recommended to adopt 110-case 1 and 110-case 3 at low and high wind speeds, respectively, in the wind directions of 90° and −90°, while 110-case 2 is always the best choice in the 0° wind direction.
Calculating the Energy Yield of Si-Based Solar Cells for Belgium and Vietnam Regions at Arbitrary Tilt and Orientation under Actual Weather Conditions
Authors: Nguyen D. P. N. , Lauwaert Johan
Published: June 2020

Predicting actual energy harvesting of a photovoltaic (PV) installation as per site-specific conditions is essential, from the customer’s point of view, to choose suitable PV technologies as well as orientations, since most PVs usually have been designed and evaluated under standard illumination. Hence, the tendency lives in the PV community to evaluate the performance on the energy yield and not purely on the efficiency. The major drawback is that weather conditions play an important role, and recording solar spectra in different orientations is an expensive and time-consuming business. We, therefore, present a model to calculate the daily, monthly and annual energy yield of Si-based PV installations included in commercial panels as well as tandem solar cells. This methodology will be used to evaluate the benefit of potential new technologies for domestic and building integrated applications. The first advantage of such a numerical model is that the orientation of solar panels and their properties can be easily varied without extra experiments. The second advantage is that this method can be transferred to other locations since it is based on a minimum of input parameters. In this paper, the energy yield of PV installations for different regions in Belgium and Vietnam will be calculated.
Optimum Electrical and Dielectric Performance of Multi-Walled Carbon Nanotubes Doped Disposed Transformer Oil
Authors: Suhaimi Nur Sabrina , Md Din Muhamad Faiz , Abdul Rahman Abdul Rashid , Abdul Hamid Mardhiah Hayati , Mohamad Amin Nur Aqilah , Wan Zamri Wan Fathul Hakim , Wang Jianli
Published: June 2020

This paper intends to prepare a nanofluid sample by suspending Multi-walled Carbon Nanotubes (MWCNTs) at 0.005g/L concentration and analyze the behavior of electrical and dielectric properties based on the International Electrotechnical Commision test method. In order to validate the effectiveness of MWCNT nanofluid, alternating current breakdown voltage (BDV), negative polarity lightning impulse (LI), dielectric permittivity, dissipation factor (DF), DC resistivity and Raman structural measurement are executed accordingly. In the following, an analysis of the statistical distribution using the two-parameter Weibull distribution law of BDV and LI are evaluated at four experimental conditions to predict the probability of breakdown occurring at different percentages. Based on the observation, the MWCNT filler has a substantial effect in improving the BDV and LI characteristics of disposed mineral oil. The permittivity, DF and resistivity performance of MWCNT nanofluid from 25 °C to 90 °C also produces comparable and reliable performance as a fresh transformer oil. As for Raman structure, the revolution of transformer oil by doping MWCNT does not disrupt the original chemical structure of mineral oil. Hence, this study proves the improvement of the electrical and the behavior of dielectric properties and chemical structure of nanofluid, providing a huge contribution towards the development of insulating materials for transformer application.
Impact of Intersection Control on Battery Electric Vehicle Energy Consumption
Authors: Ahn Kyoungho , Park Sangjun , Rakha Hesham A.
Published: June 2020

Battery electric vehicle (BEV) sales have significantly increased in recent years. They have different energy consumption patterns compared to the fuel consumption patterns of internal combustion engine vehicles (ICEVs). This study quantified the impact of intersection control approaches—roundabout, traffic signal, and two-way stop controls—on BEVs’ energy consumption. The paper systematically investigates BEVs’ energy consumption patterns compared to the fuel consumption of ICEVs. The results indicate that BEVs’ energy consumption patterns are significantly different than ICEVs’ patterns. For example, for BEVs approaching a high-speed intersection, the roundabout was found to be the most energy-efficient intersection control, while the two-way stop sign was the least efficient. In contrast, for ICEVs, the two-way stop sign was the most fuel-efficient control, while the roundabout was the least efficient. Findings also indicate that the energy saving of traffic signal coordination was less significant for BEVs compared to the fuel consumption of ICEVs since more regenerative energy is produced when partial or poorly coordinated signal plans are implemented. The study confirms that BEV regenerative energy is a major factor in energy efficiency, and that BEVs recover different amounts of energy in different urban driving environments. The study suggests that new transportation facilities and control strategies should be designed to enhance BEVs’ energy efficiency, particularly in zero emission zones.
Selection of a Suitable Rheological Model for Drilling Fluid Using Applied Numerical Methods
Authors: Wiśniowski Rafał , Skrzypaszek Krzysztof , Małachowski Tomasz
Published: June 2020

The accuracy of fitting the rheological model to the properties of actual drilling fluid minimises the errors of the calculated technological parameters applied while drilling oil wells. This article presents the methodology of selecting the optimum drilling fluid rheological model. Apart from classical rheological models, i.e., the Newtonian, Bingham Plastic, Casson, Ostwald de Waele and Herschel–Bulkley models, it has been proposed to consider the Vom Berg and Hahn-Eyring models, which have not been applied to describe drilling fluids so far. In the process of determining rheological parameters for the Bingham Plastic, Casson, Ostwald de Waele and Newtonian models, it is proposed to use a linear regression method. In the case of the Herschel–Bulkley, Vom Berg and Hahn-Eyring models, it is suggested to use a non-linear regression method. Based on theoretical considerations and mathematical relations developed in the Department of Drilling and Geoengineering, Drilling, Oil and Gas Faculty, at AGH University of Science and Technology, an original computer program called Rheosolution was developed, which enables automation of the process of determining the optimum drilling fluid rheological model. Some examples show the practical application of the method of selecting the optimum drilling fluid rheological model. Taking into account data from actual measurements of drilling fluid properties, it has been proven that the Vom Berg and Hahn-Eyring rheological models are best fitted to the description of drilling fluid rheological parameters.
Development of Small-Sized Lead Inserted Laminated Rubber Bearing for Nuclear Component Seismic Isolation
Authors: Koo Gyeong-Hoi , Jung Jin-Young , Lee Jin-Hyeong , Shin Tae-Myung , Park Jin-Young
Published: June 2020

This paper presents a design specification of the small-sized lead inserted laminated rubber bearing (LRB) for application to nuclear component seismic isolation and describes the results of test verification on design performance parameters such as effective horizontal stiffness, equivalent viscous damping ratio, design seismic isolation frequency, and ultimate shear deformation. To do this, two types of LRB, having the same vertical design load of 10 kN but with different shape factors, are designed, fabricated, and tested by the quasi-static procedures. To determine the effective horizontal stiffness and the equivalent damping value from the test results, the new method is proposed and compared with the methods of the ASCE and ISO standards in case that the tangential stiffness curve is not linear in tests. From the comparison between tests and design specifications in the performance parameters, it was found that the design specifications developed in this paper are in a good agreement with the test results. Furthermore, the target design shear deformation limits are confirmed to have sufficient design margins in ultimate shear deformation tests.
Trade-Offs in Net Life Cycle Energy Balance and Water Consumption in California Almond Orchards
Authors: Marvinney Elias , Ro Jin Wook , Kendall Alissa
Published: June 2020

Perennial cropping systems, such as almond orchards and vineyards, increasingly dominate California’s agricultural landscape. In California’s leading agricultural region, the Central Valley, woody perennials comprise about half of total farmland. Woody perennial orchards produce high value food crops such as almonds, but also generate significant woody biomass which, where feasible, is used to generate biomass-derived electricity. Because of its semi-arid climate, California agriculture is heavily dependent on irrigation, which in some regions, requires energy-intensive pumping processes for both surface and groundwater. This research study explores the tradeoffs in economic, energy and water efficiency, considering the response of almond orchards to water application rates, using a life cycle basis for calculations and considering water scarcity, to reveal one part of the food-energy-water nexus. Findings indicate economic efficiency, represented by business-as-usual practices by growers, and which prioritizes almond yield, does not correspond to the lowest net-energy consumption (i.e. energy consumption minus bioenergy production). Bioenergy production follows a parabolic relationship with applied water, due to almond yield and growth response to water availability. Thus, the net energy footprint of almond production is minimized at about −45% of business-as-usual applied water, at odds with the economic demands of the almond industry that prioritize high value food production.
Effects of Non-Industrial Wood Ash (NIWA) Applications on Soil Chemistry and Sugar Maple (Acer saccharum, Marsh.) Seedling Growth in an Acidic Sugar Bush in Central Ontario
Authors: Deighton Holly D. , Watmough Shaun A.
Published: June 2020

Research Highlights: In central Ontario, large quantities of non-industrial wood ash (NIWA) are generated and could be used as a forest soil amendment to counteract soil acidification and base cation depletion caused by decades of acid deposition. Background and Objectives: The properties and biogeochemical responses of NIWA have not been thoroughly explored, and field experiments must be conducted before NIWA can be regulated as a forest soil amendment in Ontario. Materials and Methods: In this study, soil chemistry and sugar maple (Acer saccharum, Marsh.) seedling growth and chemistry were measured in an acidic sugar bush over twelve months following a NIWA field experiment. Plots (2 m by 2 m) were established with sugar maple, white pine (Pinus strobus L.), and yellow birch (Betula alleghaniensis Britt.) NIWA treatments applied at rates of 6 Mg ha−1 along with untreated control plots. Results: Ash chemistry varied significantly among species and yellow birch ash generally had much higher metal concentrations compared with other species. Following ash application, significant increases in soil pH and calcium and magnesium concentrations were observed, however the level of response varied by treatment. Foliar concentrations of base cations in sugar maple seedlings significantly increased in ash treatments and there was no significant treatment effect on foliar metal concentrations or seedling growth. In roots and shoots, concentrations of several metals (manganese, aluminum, iron, boron, arsenic, cadmium, zinc, copper, lead, chromium, and nickel) increased after ash application, however response was most pronounced in yellow birch ash. Conclusions: These results suggest that application of NIWA can counteract the lasting effects of acid rain by increasing soil pH and base cation concentrations, as well as increasing sugar maple seedling foliar nutrient concentrations, but ashes from species with high metal contents may also increase metal availability to vegetation, at least in the short-term.
Changes in Physical Meat Traits, Protein Solubility, and the Microstructure of Different Beef Muscles during Post-Mortem Aging
Authors: Feng Yong-Hong , Zhang Song-Shan , Sun Bao-Zhong , Xie Peng , Wen Kai-Xin , Xu Chen-Chen
Published: June 2020

This study was performed to compare the differences in pH, myofibril fragmentation index (MFI), total protein solubility (TPS), sarcoplasmic protein solubility (SPS), myofibrillar protein solubility (MPS), and the microstructure of seven beef muscles during aging. From the six beef carcasses of Xinjiang brown cattle, a total of 252 samples from semitendinosus (ST), longissimus thoracis (LT), rhomboideus (RH), gastrocnemius (GN), infraspinatus (IN), psoas major (PM), and biceps femoris (BF) muscles were collected, portioned, and assigned to six aging periods (1, 3, 7, 9, 11, and 14 day/s) and 42 samples were used per storage period. IN muscle showed the highest pH (p < 0.05) from 1 to 14 days and the lowest TPS (p < 0.01) from 9 to 14 days with respect to the other muscles. Moreover, the changes in IN were further supported by transmission electron microscopy due to the destruction of the myofibril structure. The highest value of MFI was tested in ST muscle from 7 to 14 days. The total protein solubility in PM, RH, and GN muscles were not affected (p > 0.05) as the aging period increased. The lowest TPS was found in the RH muscle on day 1, 3, and 7 and in the IN muscle on day 9, 11, and 14. The pH showed negative correlations with the MFI, TPS, and MPS (p < 0.01). The results suggest that changes in protein solubility and muscle fiber structure are related to muscle location in the carcass during aging. These results provide new insights to optimize the processing and storage of different beef muscles and enhance our understanding of the biological characteristics of Xinjiang brown cattle muscles.
Effect of Substitution of Rice Flour with Quinoa Flour on the Chemical-Physical, Nutritional, Volatile and Sensory Parameters of Gluten-Free Ladyfinger Biscuits
Authors: Cannas Michela , Pulina Simone , Conte Paola , Del Caro Alessandra , Urgeghe Pietro Paolo , Piga Antonio , Fadda Costantino
Published: June 2020

The present study investigates the effect of partial or total substitution of rice flour (RF) with quinoa flour (QF) (at 25%, 50%, 75% and 100%) on the chemical-physical, nutritional, and sensory characteristics, as well as the volatile compounds, of ladyfinger biscuits. All quinoa-based formulations positively affected the crust colour, endowing it with lower ‘lightness’ and higher ‘redness’ values, giving the biscuits a more appealing crust colour. Biscuits with higher percentages of QF also had better structure, as they were softer. The substitution of RF with QF significantly improved the nutritional profile of the biscuits, as a result of the increase in protein, lipid, ash, total soluble (SP) and insoluble polyphenol (IP), flavonoid, and antioxidant activity levels, which increased linearly with the substitution rate. Quinoa supplementation led to an increase in volatile compounds that were nearly always characterised by positive olfactory attributes. Sensory analysis revealed that the maximal substitution rate of QF able to maintain an adequate consumer acceptability rating is probably 50%, as higher percentages impaired acceptability due to the presence of herbaceous and bitter tastes, even if the consumers also rated these samples as healthier and softer to touch.
Numerical Solution of Fractional Order Burgers’ Equation with Dirichlet and Neumann Boundary Conditions by Reproducing Kernel Method
Authors: Saldır Onur , Sakar Mehmet Giyas , Erdogan Fevzi
Published: June 2020

In this research, obtaining of approximate solution for fractional-order Burgers’ equation will be presented in reproducing kernel Hilbert space (RKHS). Some special reproducing kernel spaces are identified according to inner products and norms. Then an iterative approach is constructed by using kernel functions. The convergence of this approach and its error estimates are given. The numerical algorithm of the method is presented. Furthermore, numerical outcomes are shown with tables and graphics for some examples. These outcomes demonstrate that the proposed method is convenient and effective.
Application of Genetically Engineered Pigs in Biomedical Research
Authors: Hryhorowicz Magdalena , Lipiński Daniel , Hryhorowicz Szymon , Nowak-Terpiłowska Agnieszka , Ryczek Natalia , Zeyland Joanna
Published: June 2020

Progress in genetic engineering over the past few decades has made it possible to develop methods that have led to the production of transgenic animals. The development of transgenesis has created new directions in research and possibilities for its practical application. Generating transgenic animal species is not only aimed towards accelerating traditional breeding programs and improving animal health and the quality of animal products for consumption but can also be used in biomedicine. Animal studies are conducted to develop models used in gene function and regulation research and the genetic determinants of certain human diseases. Another direction of research, described in this review, focuses on the use of transgenic animals as a source of high-quality biopharmaceuticals, such as recombinant proteins. The further aspect discussed is the use of genetically modified animals as a source of cells, tissues, and organs for transplantation into human recipients, i.e., xenotransplantation. Numerous studies have shown that the pig (Sus scrofa domestica) is the most suitable species both as a research model for human diseases and as an optimal organ donor for xenotransplantation. Short pregnancy, short generation interval, and high litter size make the production of transgenic pigs less time-consuming in comparison with other livestock species This review describes genetically modified pigs used for biomedical research and the future challenges and perspectives for the use of the swine animal models.
Novel Insight into How Nurses Working at PH Specialist Clinics in Sweden Perceive Their Work
Authors: Ivarsson Bodil , Kjellström Barbro
Published: June 2020

Outpatient pulmonary hypertension (PH) specialist centers have an important role in the optimal management of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). The aim of the present study was to gain an understanding of the work facing nurses at the outpatient PH specialist centers in Sweden. All nurses (n = 14) working at the outpatient PH specialist centers in Sweden were included. Qualitative content analysis was employed to analyze the interviews, wherein an overarching theme emerged: “Build and maintain a relationship with the patient”. Three categories described the nurses’ experiences: “Ambiguous satisfaction regarding information and communication”, “Acting as a coordinator” and “Professional and personal development”. To provide good patient care, the nurses described the key components as the ability to give information on all aspects of the disease and their availability by phone for patients, their relatives, and other healthcare resources. This requires evidence-based, specialist knowledge about the disease, its care, and treatments as well as experience. In conclusion, working as a nurse at the outpatient PH specialist centers highlight the advantages, expectations, and difficulties in working with patients with a rare and life-threatening illness. The overall knowledge and skills were high, but the nurses expressed a need for in-depth and continued training.
Factors Impacting Family Planning Use in Mali and Senegal
Authors: Sidibe Aissata Mahamadou , Kadetz Paul I , Hesketh Therese
Published: June 2020

The total fertility rate in Mali (6.2) is the third highest in the world. Despite sociocultural similarities, the total fertility rate in neighboring Senegal is 4.2. The aim of this study is to identify factors which may help to explain the differences between the two countries and which may thereby inform family planning policy in Mali. A cross-sectional study was conducted with a convenience sample of 602 married women aged 16–50 from urban and rural sites in southern Mali and Senegal. A total of 298 respondents from Mali and 304 from Senegal completed a structured questionnaire between July and October 2018. In total, 11.1% of the Malian respondents and 30.9% of the Senegalese respondents were currently using family planning, and 34.6% and 40.5%, respectively, had ever used a modern family planning method. Pressure from husbands was cited as a primary influence for having more children (in 50.3% of Malians and 45.4% of Senegalese, p = 0.000). Women’s age, education level, and knowledge of different contraceptive methods were associated with ever use of contraceptives. After adjustment for confounders, discussing family planning with one’s husband was the strongest predictor of contraceptive use among both Senegalese (OR = 3.4, 95% CI (1.9–6.3), p = 0.000) and Malian respondents (OR = 7.3, (4.1–13.3), p = 0.000).
Modulation of Endothelial Glycocalyx and Microcirculation in Healthy Young Men during High-Intensity Sprint Interval Cycling-Exercise by Supplementation with Pomegranate Extract. A Randomized Controlled Trial
Authors: Pranskuniene Zivile , Belousoviene Egle , Baranauskiene Neringa , Eimantas Nerijus , Vaitkaitiene Egle , Bernatoniene Jurga , Brazaitis Marius , Pranskunas Andrius
Published: June 2020

The natural components of the pomegranate fruit may provide additional benefits for endothelial function and microcirculation. It was hypothesized that supplementation with pomegranate extract might improve glycocalyx properties and microcirculation during acute high-intensity sprint interval cycling exercise. Eighteen healthy and recreationally active male volunteers 22–28 years of age were recruited randomly to the experimental and control groups. The experimental group was supplemented with pomegranate extract 20 mL (720 mg phenolic compounds) for two weeks. At the beginning and end of the study, the participants completed a high-intensity sprint interval cycling-exercise protocol. The microcirculation flow and density parameters, glycocalyx markers, systemic hemodynamics, lactate, and glucose concentration were evaluated before and after the initial and repeated (after 2 weeks supplementation) exercise bouts. There were no significant differences in the microcirculation or glycocalyx over the course of the study (p < 0.05). The lactate concentration was significantly higher in both groups after the initial and repeated exercise bouts, and were significantly higher in the experimental group compared to the control group after the repeated bout: 13.2 (11.9–14.8) vs. 10.3 (9.3–12.7) mmol/L, p = 0.017. Two weeks of supplementation with pomegranate extract does not influence changes in the microcirculation and glycocalyx during acute high-intensity sprint interval cycling-exercise. Although an unexplained rise in blood lactate concentration was observed.
Development of Novel Method for Immobilizing TMAH-Degrading Microbe into Pellet and Characterization Tool, for Verifying Its Robustness in Electronics Wastewater Treatment
Authors: Chung Seungjoon , Choi Jeongyun , Chung Jinwook
Published: June 2020

This study describes an immobilization method of enriched microorganism, for robustly degrading organic compounds, including tetramethyl ammonium hydroxide (TMAH) in electronics wastewater without an increase of total organic carbon (TOC) in effluent. The enriched TMAH degrading bacteria was entrapped inside the pellets through polymerization. Polymerization conditions were optimized in terms of long-term TOC leak tests of pellet. Among several methods, a differential scanning calorimetry (DSC) analysis was found to be effective for the hands-on evaluation of stability in pellet. Stable pellets showed less than 10 J/g of curing heat by DSC analysis. This method is suitable for the optimization of polymerization conditions and controlling the quality of pellets. The removal efficiency of TMAH was over 95% and effluent concentration of TOC was below 100 ppb. The viability test results revealed that entrapped microorganisms were actively survived after five months of operations. This immobilization method is strongly suggested as a new strategy for the wastewater reuse process in low-strength electronics wastewater.
Governing Noncommunicable Diseases Through Political Rationality and Technologies of Government: A Discourse Analysis
Authors: Yang Joshua S. , Mamudu Hadii M. , Mackey Timothy K.
Published: June 2020

In the last two decades, global action to address noncommunicable diseases (NCDs) has accelerated, but policy adoption and implementation at the national level has been inadequate. This analysis examines the role of rationalities of governing, or governmentality, in national-level adoption of global recommendations. Critical discourse analysis was conducted using 49 formal institutional and organizational documents obtained through snowball sampling methodology. Text were coded using a framework of five forms of governmentality and analyzed to describe the order of discourse which has emerged within the global NCD policy domain. The dominant political rationality used to frame NCDs is rooted in risk governmentality. Recommendations for tobacco control and prevention of harmful alcohol use rely on a governmentality of police mixed with discipline. The promotion of physical activity relies heavily on disciplinary governmentality, and the prevention of unhealthy diet mixed disciplinary measures, discipline, and neoliberal governmentalities. To translate global NCD prevention and control strategies to national action, acceptability for the political rationalities embodied in policy options must be nurtured as new norms, procedures, and institutions appropriate to the political rationalities of specific interventions are developed.
Randomised Controlled Feasibility Study of the MyHealthAvatar-Diabetes Smartphone App for Reducing Prolonged Sitting Time in Type 2 Diabetes Mellitus
Authors: Bailey Daniel P. , Mugridge Lucie H. , Dong Feng , Zhang Xu , Chater Angel M.
Published: June 2020

This study evaluated the feasibility and acceptability of a self-regulation smartphone app for reducing prolonged sitting in people with Type 2 diabetes mellitus (T2DM). This was a two-arm, randomised, controlled feasibility trial. The intervention group used the MyHealthAvatar-Diabetes smartphone app for 8 weeks. The app uses a number of behaviour change techniques aimed at reducing and breaking up sitting time. Eligibility, recruitment, retention, and completion rates for the outcomes (sitting, standing, stepping, and health-related measures) assessed trial feasibility. Interviews with participants explored intervention acceptability. Participants with T2DM were randomised to the control (n = 10) and intervention groups (n = 10). Recruitment and retention rates were 71% and 90%, respectively. The remaining participants provided 100% of data for the study measures. The MyHealthAvatar-Diabetes app was viewed as acceptable for reducing and breaking up sitting time. There were preliminary improvements in the number of breaks in sitting per day, body fat %, glucose tolerance, attitude, intention, planning, wellbeing, and positive and negative affect in favour of the intervention group. In conclusion, the findings indicate that it would be feasible to deliver and evaluate the efficacy of the MyHealthAvatar-Diabetes app for breaking up sitting time and improving health outcomes in a full trial.
The Relationship between Physical Activity Levels and Mental Health in Individuals with Spinal Cord Injury in South Korea
Authors: Kim Dong-il , Lee Jeongmin , Park Hyuna , Jeon Justin Y.
Published: June 2020

Background: The aim of this study was to assess the relationship between physical activity (PA) levels and mental health in individuals with spinal cord injury (SCI). Methods: Three hospitals in the Seoul metropolitan area were invited to recruit patients with SCI (n = 103). PA levels were measured by the Leisure Score Index of the Godin Leisure-Time Exercise Questionnaire (GLTEQ). The Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder-7 (GAD-7) questionnaire, and Multidimensional Scale of Perceived Social Support (MSPSS) were used to assess mental health. Results: Compared to the least physically active participants (1st tertile, 44.09 ± 52.74 min/week), the most physically active participants (3rd tertile, 670.86 ± 354.97 min/week) scored significantly lower on PHQ-9 (17.03 ± 5.70 vs. 12.49 ± 4.01, p < 0.001), GAD-7 (13.24 ± 4.78 vs. 9.86 ± 3.15, p < 0.001), while significantly higher MSPSS (51.24 ± 10.17 vs. 61.37 ± 11.90, p < 0.001) after the results were adjusted for age, gender, American Spinal Cord Injury Association impairment scale, and impaired spinal cord levels. Multivariate linear regression analysis showed that the PA was a significant predictor of depression (β = −1.50, p = 0.01), anxiety (β = −1.12, p = 0.02), and social support (β = 4.04, p = 0.01). Conclusion: Higher PA participation was associated with lower depression, anxiety, and higher social support scores.
Risk and Protective Factors for Bullying at 11 Years of Age in a Spanish Birth Cohort Study
Authors: Babarro Izaro , Andiarena Ainara , Fano Eduardo , Lertxundi Nerea , Vrijheid Martine , Julvez Jordi , Barreto Florencia B. , Fossati Serena , Ibarluzea Jesus
Published: June 2020

(1) Background: Bullying affects a large number of children worldwide. This study has two objectives, to provide data on the prevalence of bullying in Spain, and to identify risk and protective factors associated with bullying. (2) Methods: Participants were 858 eleven-year-old children. Bullying was assessed using a short version of the Olweus Bully Victim Questionnaire, and the following data were gathered to explore potential predictors: individual (inattention, behavior problems, attention deficit hyperactivity disorder symptomatology, traumatic life events), family-related (sociodemographic characteristics, family context, child-parent relations), school-related (school characteristics, peer and social support, school environment) and community-related data. (3) Results: 9.3% of the children were victims, 1.4% bullies and 1.6% bully-victims. Results showed that a higher level of attention deficit hyperactivity disorder symptomatology increased the risk of victimization, whereas having better relationships with parents and stronger social support were associated with a lower risk of victimization. Children having strong peer relationships and social support was also associated with less risk of perpetrating bullying. Finally, having behavior problems at 8 years of age was associated with being a bully-victim. (4) Conclusions: The findings emphasize the importance of studying all bullying predictors together, regarding three of the roles children may take in bullying situations.
Exploring Urban Spatial Features of COVID-19 Transmission in Wuhan Based on Social Media Data
Authors: Peng Zhenghong , Wang Ru , Liu Lingbo , Wu Hao
Published: June 2020

During the early stage of the COVID-19 outbreak in Wuhan, there was a short run of medical resources, and Sina Weibo, a social media platform in China, built a channel for novel coronavirus pneumonia patients to seek help. Based on the geo-tagging Sina Weibo data from February 3rd to 12th, 2020, this paper analyzes the spatiotemporal distribution of COVID-19 cases in the main urban area of Wuhan and explores the urban spatial features of COVID-19 transmission in Wuhan. The results show that the elderly population accounts for more than half of the total number of Weibo help seekers, and a close correlation between them has also been found in terms of spatial distribution features, which confirms that the elderly population is the group of high-risk and high-prevalence in the COVID-19 outbreak, needing more attention of public health and epidemic prevention policies. On the other hand, the early transmission of COVID-19 in Wuhan could be divide into three phrases: Scattered infection, community spread, and full-scale outbreak. This paper can help to understand the spatial transmission of COVID-19 in Wuhan, so as to propose an effective public health preventive strategy for urban space optimization.
Circulating Levels of Brain-Enriched MicroRNAs Correlate with Neuron Specific Enolase after Cardiac Arrest—A Substudy of the Target Temperature Management Trial
Authors: Stefanizzi Francesca Maria , Nielsen Niklas , Zhang Lu , Dankiewicz Josef , Stammet Pascal , Gilje Patrik , Erlinge David , Hassager Christian , Wise Matthew P. , Kuiper Michael , Friberg Hans , Devaux Yvan , Salgado-Somoza Antonio
Published: June 2020

Outcome prognostication after cardiac arrest (CA) is challenging. Current multimodal prediction approaches would benefit from new biomarkers. MicroRNAs constitute a novel class of disease markers and circulating levels of brain-enriched ones have been associated with outcome after CA. To determine whether these levels reflect the extent of brain damage in CA patients, we assessed their correlation with neuron-specific enolase (NSE), a marker of brain damage. Blood samples taken 48 h after return of spontaneous circulation from two groups of patients from the Targeted Temperature Management trial were used. Patients were grouped depending on their neurological outcome at six months. Circulating levels of microRNAs were assessed by sequencing. NSE was measured at the same time-point. Among the 673 microRNAs detected, brain-enriched miR9-3p, miR124-3p and miR129-5p positively correlated with NSE levels (all p < 0.001). Interestingly, these correlations were absent when only the good outcome group was analyzed (p > 0.5). Moreover, these correlations were unaffected by demographic and clinical characteristics. All three microRNAs predicted neurological outcome at 6 months. Circulating levels of brain-enriched microRNAs are correlated with NSE levels and hence can reflect the extent of brain injury in patients after CA. This observation strengthens the potential of brain-enriched microRNAs to aid in outcome prognostication after CA.
Modeling Cardiac Disease Mechanisms Using Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Progress, Promises and Challenges
Authors: Parrotta Elvira Immacolata , Lucchino Valeria , Scaramuzzino Luana , Scalise Stefania , Cuda Giovanni
Published: June 2020

Cardiovascular diseases (CVDs) are a class of disorders affecting the heart or blood vessels. Despite progress in clinical research and therapy, CVDs still represent the leading cause of mortality and morbidity worldwide. The hallmarks of cardiac diseases include heart dysfunction and cardiomyocyte death, inflammation, fibrosis, scar tissue, hyperplasia, hypertrophy, and abnormal ventricular remodeling. The loss of cardiomyocytes is an irreversible process that leads to fibrosis and scar formation, which, in turn, induce heart failure with progressive and dramatic consequences. Both genetic and environmental factors pathologically contribute to the development of CVDs, but the precise causes that trigger cardiac diseases and their progression are still largely unknown. The lack of reliable human model systems for such diseases has hampered the unraveling of the underlying molecular mechanisms and cellular processes involved in heart diseases at their initial stage and during their progression. Over the past decade, significant scientific advances in the field of stem cell biology have literally revolutionized the study of human disease in vitro. Remarkably, the possibility to generate disease-relevant cell types from induced pluripotent stem cells (iPSCs) has developed into an unprecedented and powerful opportunity to achieve the long-standing ambition to investigate human diseases at a cellular level, uncovering their molecular mechanisms, and finally to translate bench discoveries into potential new therapeutic strategies. This review provides an update on previous and current research in the field of iPSC-driven cardiovascular disease modeling, with the aim of underlining the potential of stem-cell biology-based approaches in the elucidation of the pathophysiology of these life-threatening diseases.
Modeling the Effect of Composition on Formation of Aerosolized Nanoemulsion System Encapsulating Docetaxel and Curcumin Using D-Optimal Mixture Experimental Design
Authors: Asmawi Azren Aida , Salim Norazlinaliza , Abdulmalek Emilia , Abdul Rahman Mohd Basyaruddin
Published: June 2020

The synergistic anticancer effect of docetaxel (DTX) and curcumin (CCM) has emerged as an attractive therapeutic candidate for lung cancer treatment. However, the lack of optimal bioavailability because of high toxicity, low stability, and poor solubility has limited their clinical success. Given this, an aerosolized nanoemulsion system for pulmonary delivery is recommended to mitigate these drawbacks. In this study, DTX- and CCM-loaded nanoemulsions were optimized using the D-optimal mixture experimental design (MED). The effect of nanoemulsion compositions towards two response variables, namely, particle size and aerosol size, was studied. The optimized formulations for both DTX- and CCM-loaded nanoemulsions were determined, and their physicochemical and aerodynamic properties were evaluated as well. The MED models achieved the optimum formulation for DTX- and CCM-loaded nanoemulsions containing a 6.0 wt% mixture of palm kernel oil ester (PKOE) and safflower seed oils (1:1), 2.5 wt% of lecithin, 2.0 wt% mixture of Tween 85 and Span 85 (9:1), and 2.5 wt% of glycerol in the aqueous phase. The actual values of the optimized formulations were in line with the predicted values obtained from the MED, and they exhibited desirable attributes of physicochemical and aerodynamic properties for inhalation therapy. Thus, the optimized formulations have potential use as a drug delivery system for a pulmonary application.
BRG1 Is Dispensable for Sertoli Cell Development and Functions in Mice
Authors: Wang Shuai , Wang Pengxiang , Liang Dongli , Wang Yuan
Published: June 2020

Sertoli cells are somatic supporting cells in spermatogenic niche and play critical roles in germ cell development, but it is yet to be understood how epigenetic modifiers regulate Sertoli cell development and contribution to spermatogenesis. BRG1 (Brahma related gene 1) is a catalytic subunit of the mammalian SWI/SNF chromatin remodeling complex and participates in transcriptional regulation. The present study aimed to define the functions of BRG1 in mouse Sertoli cells during mouse spermatogenesis. We found that BRG1 protein was localized in the nuclei of both Sertoli cells and germ cells in seminiferous tubules. We further examined the requirement of BRG1 in Sertoli cell development using a Brg1 conditional knockout mouse model and two Amh-Cre mouse strains to specifically delete Brg1 gene from Sertoli cells. We found that the Amh-Cre mice from Jackson Laboratory had inefficient recombinase activities in Sertoli cells, while the other Amh-Cre strain from the European Mouse Mutant Archive achieved complete Brg1 deletion in Sertoli cells. Nevertheless, the conditional knockout of Brg1 from Sertoli cells by neither of Amh-Cre strains led to any detectable abnormalities in the development of either Sertoli cells or germ cells, suggesting that BRG1-SWI/SNF complex is dispensable to the functions of Sertoli cells in spermatogenesis.