bluuebunny/crossref_metadata_2025 huggingface dataset:
La industria en los municipios de Guadalajara, Zapopan, Tlaquepaque y Tonalá
Authors:   Universidad de Guadalajara, Reyes Nodhal Rosa Elena , Alvarado Castellanos Teresita de Jesús ,   Universidad de Guadalajara, Guevara Ernesto Marcelo ,   Universidad de Guadalajara
Published: June 2023

En de la Zona Metropolitana de Guadalajara (zmg), como en la mayor parte de las grandes ciudades del país, la problemática industrial se encuentra estrechamente relacionada con su esquema de desarrollo histórico. En los años ochenta la superficie ocupada por industrias en la zmg casi se duplicó: pasó de 400 a casi 750 ha. En esta zona se asentaron establecimientos manufactureros grandes, pequeños y medianos. Los primeros, se instalaron en suelo clasificado como área industrial. Las pequeña y mediana empresas, por su parte, se establecieron en forma dispersa y anárquica, incluso en áreas habitacionales. Para el año 2012 se calcularon 42 023 establecimientos según estimaciones elaboradas con base en la tasa de crecimiento anual de 0.375.
Aspectos multidisciplinarios en torno al aprovechamiento de las aguas de la Cuenca Hidrográfica Rio Verde
Authors:   Universidad de Guadalajara, Aguirre Jiménez Alma Alicia , Morán Martínez Francisco ,   Universidad de Guadalajara
Published: June 2023

El presente trabajo analiza las situaciones derivadas de las acciones legales para establecer lineamientos de ordenación de los aprovechamientos y de la protección de las aguas nacionales destinadas como reservas para uso doméstico y público urbano. Dedica especial atención a los aspectos normativos emitidos en torno a la gestión de la transferencia de los recursos hídricos de la cuenca rio Verde a la cuenca Santiago específicamente a la Zona Conurbada de Guadalajara (ZCG) y a la ciudad de León, Guanajuato (CLG); se hace énfasis en la participación de los gobiernos de los estados de Jalisco y Guanajuato, así como en la intervención del gobierno federal a través de la Comisión Nacional del Agua (CONAGUA) en dichos procesos.
Climate Change and Poverty
Authors: Schlegel Vera
Published: June 2023

Climate change and therewith climate variability as well as the frequency of extreme events could slow or possibly even reverse progress that has been made regarding poverty reduction. Developing countries and especially the (rural) poor living there are suspected to suffer most from the impacts of climate change. Reasons for that are geographic and climatic conditions, dependency from natural resources, environmental systems and climate sensitive sectors as well as limited human, institutional and financial conditions. The paper examines poverty and welfare impacts of climate change on an aggregated level as well as on the microeconomic level. Impacts of climate change on the sectors economic goods and services, water, health and agricultural production are analyzed. After a case study on Mexico adaption strategies in general and in Mexico are examined and policy implications are given.
Observatorios para la Transparencia y Rendición de Cuentas en la Aplicación de los Presupuestos y Programas de la Administración Pública Federal en materia de transversalidad de la perspectiva de género Jalisco 2011. Fondo de Apoyo para la Micro y Pequeña Empresa (Fondo PyME)
Authors: Delgado Lecourtois Carmen Yolanda , Dolores Navarro Elena , Pimienta Monje María de la Luz , Arce González Jorge López
Published: June 2023

El objetivo del presente trabajo es la observación de transparencia del Presupuesto Etiquetado para Equidad de Género en el programa de Micro y Pequeñas Empresas (FONDO Pymes) Jalisco 2011, dependiente de la Secretaría de Economía. Observatorio que se realiza por encargo de la Secretaría de la Función Pública, con su debida autorización para publicarlo. Para ello, se analiza la normatividad del programa del programa de Transversalidad de Género desde los Organismos Internacionales e implicaciones sociales. La trascendencia estriba en que de 2.9 millones de establecimientos, 99% de ellos corresponden a micro, pequeñas y medianas empresas; constituye así, un sector estratégico en el desarrollo económico y social del país. Inicia por contrastar la normatividad con base en la matriz de beneficiarios sugerida por la Secretaría de la Función Pública (SFP) y por los Organismos Intermedios (OI), el caso de SEPROE y MICROJAL. Comprende un análisis porcentual de indicadores, de información de campo con directivos institucionales y la metodología FODA para la aplicación del presupuesto.
Importancia social del cultivo de frijol periodo 1990-2008
Authors:   Instituto Nacional de Investigación Forestales, Agrícolas y Precuaría-Campo Experimental Valle de México, Sangerman-Jarquín Dora María , Acosta Gallegos Jorge Alberto , Schwentesius de Rinderman Rita ,   Universidad Autónoma de Chapingo, Navarro Bravo Agustín ,   Instituto Nacional de Investigación Forestales, Agrícolas y Precuaría-Campo Experimental Valle de México, Larqué Saavedra Bertha Sofía
Published: June 2023

En México, el grano de frijol por su alto contenido de proteína es básico para la alimentación de su población; ocupa el segundo lugar en importancia nacional después del maíz. La producción de las leguminosas, principalmente la del frijol, ha disminuido a una tasa de 3.2% con un crecimiento de población mucho más rápido que el de la producción. El frijol es una leguminosa que constituye una fuente de proteínas e hidratos de carbono natural; además es abundante en vitamina B como: niacina, ácido fólico y tianina; también proporciona hierro, cobre, zinc, fósforo, potasio, magnesio y calcio, contiene un alto contenido de fibra. Existen múltiples variedades de frijol que se caracterizan por su tamaño, color, forma y tipo de crecimiento. Se considera que en total existen 70 especies; en México estás ascienden a 50, destacan cinco especies que se han domesticado Phaseolus vulgaris L. (frijol común), Phaseolus coccineus L. (frijol ayocote), Phaseolus lunatus L. (frijol comba), Phaseolus dumosus (frijol gordo) y Phaseolus acutifolius Gray (frijol tepari). En México se cultivan cerca de 70 variedades, que de acuerdo a la norma son: negros, pintos, bayos, amarillos y rosados. El cultivo del frijol presenta características propias y definidas en el marco de la soberanía alimentaria, en virtud de que representa un alimento principal para la población rural y urbana. El programa de mejoramiento genético de frijol del Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias (INIFAP) del Campo Experimental Valle de México (CEVAMEX), ha contribuido en gran medida en generar la tecnología necesaria para que el país alcance la autosuficiencia alimentaria sostenida en este cultivo. Esta tecnología incluye la liberación de variedades con mayor capacidad de rendimiento y mejor calidad alimentaria y culinaria.
Aproximación teórica a los sistemas energéticos: bases y elementos para su modelación
Authors: Arroyo González Luis Alberto , Peniche Camps Salvador ,   Universidad de Guadalajara
Published: June 2023

Los modelos energéticos son la forma como están estructurados y funcionando los sistemas energéticos en todos sus procesos, esto nos permite el análisis, la simulación y la predicción de la generación y consumo de la energía. Pero también representa un esquema teórico por medio del cual visualizamos y entendemos de una forma más sencilla el comportamiento de los mismos modelos de energía en todos y cada uno de sus procesos. Los modelos energéticos permiten la representación gráfica, escrita o explicada del funcionamiento de los sistemas energéticos.
Effects of ESG Management on Corporate Value：Focusing on the Mediating Effect of Foreign Ownership
Authors:   Korean Association Of Computers And Accounting, Baik Sang-Mi
Published: June 2023

In order to analyze the effect of ESG management on companies, this study aims to analyze the effect of ESG management on corporate value. Specifically, by analyzing the mediating effect of foreign equity shares on ESG management and corporate value, it is intended to find out the role of foreign investors, who are representative stakeholders, in domestic companies.
The results show that ESG variables reported a significant positive coefficient for the corporate value variable, Tobin’s Q. These results mean that the increase in ESG management has a significant positive effect on corporate value. In addition, both ESG variables and the interaction variable with the foreign equity ratio were found to significantly increase the corporate value. It indicates that the foreign equity ratio has an additional positive influence on corporate value.
This study provides the following contributions. First, by confirming the role of foreign investors in the relationship between ESG management and corporate value, it provided an opportunity to increase the understanding of the stakeholders of companies that perform ESG management. Second, the scope of existing research was expanded by analyzing the role of foreign investors in relation to ESG management. Third, companies can achieve higher corporate value by actively notifying foreign investors of information on ESG management. Finally, it was suggested that overall ESG management efforts can help attract corporate value and investment.
Research on ESG Performance and Tax Avoidance
Authors:   Korean Association Of Computers And Accounting, Kim Jeong-Ho , Oh Sang-Hui
Published: June 2023

The purpose of this study is to examine the relationship between the impact of a company's ESG scores on tax avoidance and to test whether these relationships are the same in recent and past years. The results of the study were as follows： First, as a result of the test of hypothesis 1, the relationship between ESG variables and BTD_R was shown in the direction of a significant amount (＋) at the level of 1%. The same results were also found in the relationship between ESG variables and BTD. This is inconsistent with the predicted hypothesis.
Second, when the dependent variable is BTD_R, ESG scores and tax avoidance are significantly positively (＋) at the 5% level for the 2020-2021 sample. On the other hand, in samples of the past two years and the interim two-year sample, ESG scores and tax avoidance did not show a significant association. In addition, when the dependent variable was BTD, there was no significant association between ESG scores and tax avoidance in the sample from 2020 to 2021. On the other hand, the relationship between ESG scores and tax avoidance was significantly negative in the 2012-2013 sample, and the same results were seen when the study sample was from 2015 to 2016.
This study studied the effect of ESG integrated scores on tax avoidance, and is significant in that the conclusions were drawn by dividing the study sample by dividing the period (recent and past). However, in the case of this study, the criteria for dividing the study period into the last two years or the last three years are vague, and in subsequent studies, it is necessary to study environmental, social, and governance from their respective perspectives.
Financial distress, audit committee, profit and loss, audit delay: An empirical study
Authors: Nurmala Putri , Wahyudi Rizki
Published: June 2023

The purpose of this study is to determine whether or not audit delay is caused by financial stress, the audit committee, or the profit and loss of the company. This study also considered a number of independent criteria, such as the severity of the financial situation, participation in the audit committee, and profit and loss. In addition to this, it incorporates the dependent variable known as audit delay. In this work, quantitative descriptive research is used. Secondary data are collected for the purpose of this investigation, and the documentation process serves as the approach for gathering data. This research focused on forty different property and real estate firms that were traded on the Indonesia Stock Exchange between the years 2016 and 2020. According to the conclusions of the research, businesses that experience a rise in profits will have a shorter audit delay, whereas businesses that experience a rise in losses will have a longer audit delay. In the meantime, financial trouble and having an audit committee don't have much to do with audit delay. 
РОЗРОБКА ТА ОБГРУНТУВАННЯ ПСИХОФІЗІОЛОГІЧНИХ ПОКАЗНИКІВ ДІАГНОСТИКИ СТРЕСОСТІЙКОСТІ МОРЯКІВ
Authors: Coрoкa О.
Published: June 2023

Стаття присвячена обґрунтуванню психофізіологічних показників діагностики стресостійкості фахівців екстремальних професій. Зокрема зазначається, що представлені методики оцінки компонентів стресостійкості за фізіологічними показниками вимагають узагальнення інформації з врахуванням їхньої вибірковості в оцінці якостей, що характеризують виокремлені компоненти стресостійкості. Згідно із представленими даними, на початку експерименту кількість обстежуваних зі стресонестійким і стресогальмівним типами особистості виявилася у контрольній та експериментальних групах приблизно однаковою. На заключному етапі експерименту відзначалися суттєві відмінності, що виразилися у кількісних змінах обстежуваних із несприятливим соціонічним типом особистості групи 2 порівняно з групою 1.
ФОРМУВАННЯ РОСІЙСЬКОЮ ФЕДЕРАЦІЄЮ НЕГАТИВНИХ СТЕРЕОТИПІВ З УКРАЇНИ ТА УКРАЇНЦІВ ТА ЇХ ВПЛИВ НА КОЛЕКТИВНИЙ ІНТЕЛЕКТ РОСІЙСЬКОГО НАСЕЛЕННЯ
Authors: Холох О. , Євсєєв І. , Халіманенко К.
Published: June 2023

У статті розглядається процес деструктивного впливу на колективний інтелект громадян російської федерації актуалізованих наявних (етнічних, історичних, соціальних) та нових стереотипів щодо України та українців від проголошення незалежності України до початку Революції Гідності. Ці стереотипи росія на системній основі використовувала для формування в росіян негативного ставлення до України та українців, що стало основою для подальшого формування “образу ворогаˮ з України та його насичення виключно негативними характеристиками.

Автори дійшли висновку, що деструктивні стереотипи щодо України та українців не відображають реальність, але систематизують та спрощують її сприйняття. Утім така економія інтелектуальних ресурсів негативно позначається на колективному інтелекті та призводить його до деградації. До того ж систематичне стереотипне мислення призводить до негативних наслідків у фізичному вимірі, а саме: до зневажливого ставлення, дискримінації, жорстокого поводження і навіть до відкритої військової агресії, спрямованої на знищення народу щодо якого були сформовані деструктивні стереотипи.
РЕЗИЛЬЄНТНІСТЬ СОЦІАЛЬНИХ СИСТЕМ В КРИЗОВИХ СТАНАХ
Authors: Волошина О.
Published: June 2023

Стаття присвячена дослідженню методології формування колективної резильєнтності як ресурсу відновлення та зростання соціальних систем в кризових станах. Мета статті полягає у обґрунтуванні взаємозалежності інтерактивних процесів формування резильєнтності на рівні індивідів, сімей і громад; аналізі методів її формування на макрорівні в кризових станах. Зроблено висновок, що процеси формування і управління резильєнтністю соціальних систем налаштовані на виконання двох завдань: По-перше, сприяти формуванню резильєнтності на мікро- та мезорівнях; по-друге, сприяти адаптації, відновленню та розвитку самої соціальної системи.
ГЕНДЕРНИЙ ПАРИТЕТ НА УКРАЇНСЬКИХ ЗЕМЛЯХ У ХIV-ХVII ст.: ПРАВА ЖІНКИ У ШЛЮБІ
Authors: Демиденко Н.
Published: June 2023

У статті досліджується українська модель гендерного паритету за часів Великого князівства Литовського та Гетьманщини. Особливий акцент зроблено на права української жінки у шлюбі за звичаєвим правом, наведено становлення рівності між чоловіками та жінками у сфері сімейних стосунків. Вказано на провідну роль християнської ідеології в формуванні ставлення щодо прав жінки, акцентовано увагу на різні погляди церкви і громади щодо вінчання та розлучення. У публікації доведено, що звичаєве право, передаючи моральний досвід поколінь, мало вирішальний вплив на гендерний паритет на українських землях включно до кінця ХVII ст.
You are what your ancestors ate: retained bufadienolide resistance in the piscivorous water cobra Naja annulata (Serpentes: Elapidae)
Authors: Fletcher Jessica , Malhotra Anita , Wüster Wolfgang
Published: June 2023

Predators exploiting chemically defended prey are generally resistant to prey toxins. However, toxin resistance usually incurs a fitness cost and is therefore often lost when no longer needed. Bufonid toads are a frequently abundant food resource, but chemically defended by a group of cardiotonic steroids, bufadienolides. Bufophagous predators have evolved a specific and near-universal mechanism of resistance to these toxins, consisting of two amino acid substitutions in the Na+/K+-ATPase H1–H2 extracellular domain. The dynamics of loss or retention of this adaptation in secondarily non-bufophagous lineages remain inadequately understood. Here we explore this topic by showing that the piscivorous banded water cobra Naja annulata retains the bufadienolide-resistant genotype of the otherwise toad-eating cobra clade. This confirms a trend for secondarily non-toad-eating snakes to retain bufadienolide resistance. Keywords: Antipredator adaptation, cardiotonic steroid, cardiac glycoside, evolution, piscivory
Optimization of technological parameters of airlift operation when drilling water wells
Authors: Borash B. R , Biletskiy M. T , Khomenko V. L , Koroviaka Ye. A , Ratov B. T
Published: June 2023

Purpose. Development of a methodology for optimizing the technological parameters of the airlift operation, based on the analysis of the pressure balance in the annulus and in the drill string that occurs during drilling. Methodology. The tasks were solved by a complex research method, which includes a review and generalization of literary and patent sources, analytical studies on existing methods for optimizing the technological parameters of drilling with reverse circulation using an airlift. Findings. It has been established that in the study on the airlift circulation method during rotary drilling with reverse circulation, an important role is played by the analysis of the pressure balance arising in the course of drilling in the annulus and in the drill string. It takes into account both hydrostatic pressures and pressure losses for pumping water and water-air mixture. A technique has been developed for assessing the effect of rate of penetration on circulation parameters. Originality. For the first time, it has been shown that the analysis of the pressure balance makes it possible to establish, with a given accuracy, the average effective values of the output parameters: the density of the water-air mixture, its upward flow rate, and the air flow rate at a given velocity of the upward flow of water as it approaches the mixer. Practical value. The proposed technique makes it possible to establish the dependence of the values of the output parameters on the depth of the well, as well as the required compressor performance to provide a given drilling fluid flow rate.
Optimization of track distribution of industrial railway stations between car designations
Authors: Nurzhaubayev Meiram , Grevtsov Serhii , Korobiova Ruslana , Manafov Elshan , Abdukarimov Sadratdin , Arpabekov Muratbek
Published: June 2023

Purpose. To improve the method for distributing the tracks of industrial railway stations for the accumulation of car groups between separate assignments. The optimization problem is to find such a distribution of classification work between the industrial marshalling yard and freight stations, as well as such a distribution of marshalling yard tracks between individual destinations, which ensures the minimum time expenditures on shunting work. Methodology. The studies were carried out using the methods of the theory of railway operation, simulation modeling and dynamic programming. Findings. The optimization problem of distribution of sorting work between the marshalling yard and freight stations of an industrial enterprise, as well as searching for such a distribution of marshalling yard tracks between individual destinations, which ensures the minimum time expenditures for shunting work, has been solved. Originality. The paper proposes a method for formalizing and solving the problem of distributing the tracks of industrial railway stations for the accumulation of car groups between individual destinations as a dynamic programming problem. Unlike the existing methods, where the number of tracks is considered as a constraint, in the proposed method, the number of tracks is an objective function argument of minimizing the duration of shunting operations, which improves the quality of the solutions obtained. Practical value. The method proposed in the paper, due to the rational distribution of the existing track arrangement of railway stations, makes it possible to reduce the time expenditures on the making- and breaking-up the trains and shunting transfers and, due to this, increase the carrying capacity of the stations, as well as reduce the cost of production of enterprises.
Activity of sotorasib against brain metastases from NSCLC harboring KRAS p.G12C mutation: a case report
Authors: Inno Alessandro , Fabiana Marchetti  , Matteo Valerio  , Niccolò Giaj Levra  , Filippo Alongi  , Giovanni Foti  , Stefania Gori
Published: June 2023

In the CodeBreaK 100 phase 2 study, sotorasib was active for patients with metastatic non-small cell lung cancer (NSCLC) harboring Kirsten rat sarcoma viral oncogene homologue (KRAS) p.G12C mutation. However, patients with untreated and/or active brain metastases were excluded from the trial, and the activity of sotorasib in the setting of brain metastases should be further investigated. Here we report the case of a KRAS p.G12C mutant NSCLC patient with three brain metastases, of whom one was untreated and the other two had progressed after radiotherapy with symptoms requiring steroids, that responded to sotorasib. Our report suggests that sotorasib may be active against untreated or progressive brain metastases, supporting further evaluation of sotorasib in this setting.
Análise estatística da mortalidade por câncer colorretal no Estado do Rio de Janeiro entre 2015 e 2019
Authors: Morais Valdimeri Queiroz da Silva , Novaes Cristiane de Oliveira
Published: June 2023

O objetivo geral do estudo foi analisar os indicadores sociais e demográficos associados à mortalidade por Câncer Colorretal no Estado do Rio de Janeiro entre 2015 e 2019. Metodologia: Trata-se de um estudo ecológico, tendo como unidades de observação 92 munícipios que compõem o Estado do Rio de Janeiro. Utilizou-se indicadores sociais e demográficos no período de 2015 a 2019 a respeito do óbito por Câncer Colorretal, tendo como variáveis: idade, sexo, raça, escolaridade e causa básica. Os dados foram apresentados através de mapa, tabelas e gráficos e analisados através do teste Shapiro-Wilk, dos testes de hipótese Qui-quadrado e de Wilcoxon no programa estatístico R. Resultados: a maior taxa de mortalidade calculada no período foi 22,10 por 100.000 habitantes, registrada no município de Mendes-RJ; as idades variaram no intervalo de 15 a 106 anos com média de 68,66; o número de óbitos de homens e de mulheres independem da raça, contudo, ao correlacionar com as causas, a raça branca é a mais acometida; tanto homens quanto mulheres tem relação de dependência com o nível de escolaridade, sendo mais frequente em pessoas com menor escolaridade; e a variável idade tem relação de dependência com a variável sexo. Conclusão: O estudo aponta que pessoas com baixa escolaridade e brancas são mais acometidos pelo Câncer Colorretal independente do sexo e idade. Espera-se que as análises deste estudo contribuam com novos estudos que visem a detecção precoce das pessoas suscetíveis no Estado do Rio de Janeiro.
Pencegahan Pernikahan Anak/Dini melalui Peningkatan Pemahaman Kesehatan Reproduksi dan Penguatan PIK-R dan RPTRA Kelurahan Cipinang Besar Utara
Authors: Trisiswati Maya , Aryenti Aryenti , Maulana Aya Yahya , Pradina Tiara Aulia
Published: June 2023

Undang-Undang No. 16 Tahun 2019 menyatakan batas minimal usia perkawinan perempuan dan laki-laki 19 tahun. Kenyataannya, perkawinan anak perempuan  15,66%  belum mencapai 16 tahun (Utari & Amalia, 2021). Perkawinan anak merupakan salah satu dari bentuk kekerasan kepada anak, terlebih bila anak dinikahkan karena mengalami kekerasan seksual atau alami kehamilan diluar pernikahan. Perlu diberikan edukasi kesehatan reproduksi kepada remaja dan orang tua untuk mencegah permasalahan kespro dan menikah usia dini. Pemberian layanan informasi , konseling kesehatan remaja dan keluarga  merupakan program strategis dalam upaya menyiapkan SDM berkualitas dengan meningkatkan pengetahuan, sikap dan keterampilan remaja dan keluarga remaja. Peningkatkan pengetahuan dan pemahaman kespro remaja, dan orang tua yang memiliki anak / remaja terutama pendewasaan usia perkawinan, penguatan PIKR  - RPTRA dan  jangka panjang menurunkan angka pernikahan pada anak usia dini. Nilai pre tes peserta orang tua  rata-rata  66,4  dan postes  85,8. Peserta remaja nilai pre tes 68,4 dan  86,8 post tes. Kegiatan pengmas efektif karena terjadi peningatkan pengetahuan peserta baik pada remaja maupun pada orang tua remaja dengan indicator hasil pre tes dan pos tes.
Association between Subjective Oral Health, Beliefs and Use of Oral Care Products in Some Adults
Authors:   The Korean Society of Oral Health Science, Kim Bo-Ram , Kim Seul-Gi , Kim Yeo-Eun , Kim Hyo-Jin , Lee Min-Kyung , Cheon Sae-Hee
Published: June 2023

Objectives: The purpose is to comprehensively investigate and analyze an association between subjective oral health, beliefs and use of oral care products in some adults to increase interest in oral health care in the future, helping oral health professionals develop educational programs and recommend the use of oral care products. Methods: From July 11th to August 19th, 2022, some adults were self-entered using an online survey. Results: There is a significant an association between subjective oral health, beliefs and use of oral care products in some adults Conclusions: In order to have oral health behavior, we propose to provide a program that can create the right oral health belief in various aspects.
The effect of Dental Hygienists' Coaching Skills on the Practice of Dental Hygiene for the Elderly, Focusing on Their Empathy for the Elderly
Authors:   The Korean Society of Oral Health Science, Jang Kyeung-Ae
Published: June 2023

Objectives: The purpose of this study was to investigate the effect of coaching skills on the practice of dental hygiene for the elderly focusing on the mediation of empathy for the elderly and targeting dental hygienists in certain regions. Methods: This study was conducted with dental hygienists in certain areas of Gyeongnam, Gyeongbuk, and Busan. Results: As a result of the mediating effect of empathy for the elderly, the coaching skills of dental hygienists and the practice of dental hygiene for the elderly were found to be meaningful. Conclusions: The importance of dental hygienists' coaching skills, empathy for the elderly and the need for education were confirmed. When developing and applying a training manual for a dental hygienist system focusing on the elderly, a program with competency in each identified area is required.
Методические документы по оценке технического состояния многоквартирных жилых домов
Authors: ЕРЕМИН Константин Иванович , ДЕНИСОВ Александр Сергеевич
Published: June 2023

Выполнен обзор содержания методических документов, разработанных в развитие свода правил СП 454.1325800.2019 "Здания жилые многоквартирные. Правила оценки аварийного и ограниченно-работоспособного технического состояния", позволяющего однозначно, на основе ограниченного числа количественных и качественных параметров определять техническое состояние жилых домов, а именно: "Методических рекомендаций по оценке технического состояния несущих строительных конструкций жилых многоквартирных зданий для признания их аварийными или ограниченно-работоспособными"; "Справочника базовых цен на обследования жилых многоквартирных зданий для признания их аварийными", которые детализируют положения свода правил в части формирования единых инструментальных методов освидетельствования технического состояния и определения цены работ по установлению аварийности жилых многоквартирных зданий; "Методических рекомендаций о составлении курса повышения квалификации специалистов по организации и выполнению работ по новым правилам оценки аварийных и ограниченно-работоспособных технических состояний жилых многоквартирных зданий".
High Vowel Syncope Failure in Urban Jordanian Arabic: A Positional
Faithfulness Treatment
Authors: Jaber Aziz
Published: June 2023

Although several studies have provided insightful accounts and analyses of
places and environments where high vowel syncope is at play in different Arabic dialects
(e.g., Abu-Salim 1987; Abu-Mansour 1995; Kiparsky 2003; McCarthy 2007), they have not
identified or accounted for circumstances in which high vowel syncope fails to apply. This
paper, thus, fills in this gap in the literature. Adopting positional faithfulness theory, the
study explains the uncharacteristic resisting behavior of certain prominent positions. It is
shown that the high vowel syncope process causes any weak high vowel to be deleted except
when occurring in one of the prominent positions of the 1) stressed syllable, 2) final syllable,
or 3) proper name subcategory. However, weak positions like unstressed syllable and non-final syllable submit to high vowel neutralizing syncope in Urban Jordanian Arabic. This
shows that syncope targets only weak structures in weak positions. .
Scavengers use natural and anthropogenic resources connecting protected areas with surrounding lands
Authors: Ho Cameron , Marzluff John M. , Stahler Daniel R. , Smith Douglas W. , Mueller Thomas , Wikelski Martin , Safi Kamran , Loretto Matthias-Claudio
Published: June 2023

Anthropogenic food subsidies can alter ecosystem processes, such as competition, predation, or nutrient transfer, and may strongly affect protected areas. Increasing recreation and ecotourism often create food subsidies, especially in the surrounding lands through fast-growing gateway communities. How the effects of these subsidies extend into protected areas when animals move across boundaries remains largely unexplored. We addressed this question by studying the movement and foraging of common ravens (Corvus corax), opportunistic scavengers that are well known to feed on predator kills and on anthropogenic food subsidies. We analyzed spatiotemporal data from 57 global positioning system (GPS)-tagged ravens, trapped within or close to Yellowstone National Park, to study their seasonal use of natural and anthropogenic food sources. Although Yellowstone National Park contains a full suite of native predators and ravens can be observed at virtually every kill site, we show that anthropogenic subsidies were utilized to a much greater extent than other natural resources, especially during winter. Important subsidies included gut piles of harvested game animals left by hunters, fat present on wastewater settling ponds, roadkill, and waste from agricultural and urban activities. These subsidies were distributed over vast areas beyond Yellowstone National Park. During fall/winter, ravens traveled longer distances (21.9 vs. 13 km) and spent more time outside Yellowstone National Park (73% of GPS points outside), mostly feeding on anthropogenic subsidies, than in spring/summer (42% of GPS points outside). This difference between seasons was more pronounced for individuals holding territories within the protected area than for those without territories. The large area over which ravens used anthropogenic food subsidies (within more than 100 km of Yellowstone National Park) affects the park’s raven population and the scavenging services they provide. We suggest that the scale of resource use must be considered by managers seeking to control expanding raven populations elsewhere.
Multiple Ehrlichia chaffeensis genes critical for persistent infection in a vertebrate host are identified as nonessential for its growth in the tick vector; Amblyomma americanum
Authors: Jaworski Deborah C. , Wang Ying , Nair Arathy , Liu Huitao , Ganta Roman R.
Published: June 2023

Ehrlichia chaffeensisis a tick-transmitted monocytic ehrlichiosis agent primarily causing the disease in people and dogs. We recently described the development and characterization of 55 random mutations inE. chaffeensis, which aided in defining the critical nature of many bacterial genes for its growth in a physiologically relevant canine infection model. In the current study, we tested 45 of the mutants for their infectivity ability to the pathogen’s tick vector;Amblyomma americanum. Four mutations resulted in the pathogen’s replication deficiency in the tick, similar to the vertebrate host. Mutations causing growth defects in both vertebrate and tick hosts included in genes coding for a predicted alpha/beta hydrolase, a putative dicarboxylate amino acid:cation symporter, a T4SS protein, and predicted membrane-bound proteins. Three mutations caused the bacterial defective growth only in the tick vector, which represented putative membrane proteins. Ten mutations causing no growth defect in the canine host similarly grew well in the tick vector. Mutations in 28 genes/genomic locations causingE. chaffeensisgrowth attenuation in the canine host were recognized as non-essential for its growth in the tick vector. The tick non-essential genes included genes coding for many metabolic pathway- and outer membrane-associated proteins. This study documents novel vector- and host-specific differences inE. chaffeensisfor its functional gene requirements.
The atherogenic index of plasma (AIP) is a predictor for the severity of coronary artery disease
Authors: Li Ya , Feng Yujia , Li Shu , Ma Yulin , Lin Jiesheng , Wan Jing , Zhao Min
Published: June 2023

Objective

Dyslipidemia is a key risk factor for coronary artery disease (CAD). This study aimed to investigate the correlation between the atherogenic index of plasma (AIP) and the severity of CAD.

Methods

2,491 patients were enrolled in this study and analyzed retrospectively, including 665 non-CAD patients as the control group and 1,826 CAD patients. The CAD patients were classified into three subgroups according to tertiles of SYNTAX score (SS). Non-high-density lipoprotein cholesterol (Non-HDL-C) was defined as serum total cholesterol (TC) minus serum high-density lipoprotein cholesterol (Non-HDL-C), atherogenic index (AI) was defined as the ratio of non-HDL-C to HDL-C; AIP was defined as the logarithm of the ratio of the concentration of triglyceride (TG) to HDL-C; lipoprotein combine index (LCI) was defined as the ratio of TC∗TG∗ low-density lipoprotein cholesterol (LDL)to HDL-C; Castelli Risk Index I (CRI I) was defined as the ratio of TC to HDL-C; Castelli Risk Index II (CRI II) was defined as the ratio of LDL-C to HDL-C.

Results

The levels of AIP (P < 0.001), AI (P < 0.001), and LCI (P = 0.013) were higher in the CAD group compared with the non-CAD group. The Spearman correlation analysis showed that AIP (r = 0.075, P < 0.001), AI (r = 0.132, P < 0.001), and LCI (r = 0.072, P = 0.001) were positively correlated with SS. The multivariate logistic regression model showed CRI I (OR: 1.11, 95% CI: 1.03–1.19, P = 0.005), CRI II (OR: 1.26, 95% CI: 1.15–1.39, P < 0.001), AI (OR: 1.28, 95% CI: 1.17–1.40, P < 0.001), AIP (OR: 2.06, 95% CI: 1.38–3.07, P < 0.001), and LCI (OR: 1.01, 95% CI: 1.01–1.02, P < 0.001) were independent predictors of severity of CAD After adjusting various confounders.

Conclusion

CRI I, CRI II, AIP, AI, and LCI were independent predictors of the severity of CAD, which could be used as a biomarker for the evaluation of the severity of CAD.
The pattern of late gadolinium enhancement by cardiac MRI in fulminant myocarditis and its prognostic implication: a two-year follow-up study
Authors: Jiang Luying , Zuo Houjuan , Liu Jingbo , Wang Jianyu , Zhang Kaiyue , Zhang Chunran , Peng Xiangyang , Liu Yujian , Wang Daowen , Li Haojie , Wang Hong
Published: June 2023

Background

Myocardial fibrosis, as quantified by late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR), provides valuable prognostic information for patients with myocarditis. However, due to the low incidence rate of fulminant myocarditis (FM) and accordingly small sample size, the knowledge about the role of LGE to patients with FM is limited.

Methods and results

A total of 44 adults with viral-FM receiving the Chinese treating regimen were included in this retrospective study. They were divided into the low LGE group and the high LGE group according to the ratio of LGE to left ventricular mass (LGE mass%). CMR exams and LGE were performed after hemodynamic assistance at discharge in all patients with FM. Routine echocardiography parameters and global longitudinal strain (GLS) at discharge and at 2-year follow-up were obtained and then compared. Both left ventricular ejection fraction (LVEF) and GLS showed no significant difference in both groups at discharge, whereas significant differences were observed at 2-year follow-up between two groups. Moreover, there were significant improvements of LVEF and GLS in the low LGE group, but not in the high LGE group during the 2-year period. Furthermore, LGE mass% was negatively correlated with GLS and LVEF.

Conclusions

There were two distinct forms of LGE presentation in patients with FM. Moreover, the cardiac function of patients with low LGE was significantly better than those with high LGE at 2-year follow-up. LGE mass% at discharge provided significant prognosis information about cardiac function of patients with FM.
IFABP levels predict visceral malperfusion in the first hours after open thoracoabdominal aortic repair
Authors: Doukas Panagiotis , Bassett Cathryn , Krabbe Hanif , Frankort Jelle , Jacobs Michael J. , Elfeky Moustafa , Gombert Alexander
Published: June 2023

Introduction

Intestinal ischemia after open thoracoabdominal aortic repairs, is a rare but devastating complication, associated with high mortality. Notoriously challenging to diagnose, visceral malperfusion necessitates immediate surgical attention. Intestinal fatty acid-binding protein (IFABP) has been proposed as a biomarker for the diagnosis of intestinal wall damage. In this prospectively conducted, observational study we evaluated the diagnostic capacity of IFABP levels in patients' serum and their correlation with visceral malperfusion.

Methods

23 patients undergoing open thoracoabdominal aortic repairs were included in this study and 8 of them were diagnosed postoperatively with visceral malperfusion—defined as a partial or complete thrombotic occlusion of the superior mesenteric artery and/or the coeliac trunk. IFABP levels and laboratory parameters often associated with intestinal ischemia (leucocytes, CRP, PCT and lactate) were measured at baseline, directly postoperatively, and at 12, 24 and 48 h after surgery. Postoperative visceral malperfusion—as revealed in CT angiography—was assessed and the predictive ability of IFABP levels to detect visceral malperfusion was evaluated with receiver-operator curve analysis.

Results

Patients with visceral malperfusion had a relevant risk for a fatal outcome (p = .001). IFABP levels were significantly elevated directly postoperatively and at 12 h after surgery in cases of visceral malperfusion. High IFABP concentrations in serum detected visceral malperfusion accurately during the first 12 h after surgery, with the maximum diagnostic ability achieved immediately after surgery (AUC 1, Sensitivity 100%, Specificity 100%, p < .001).

Conclusion

We conclude, that IFABP measurements during the first postoperative hours after open thoracoabdominal aortic surgery can be a valuable tool for reliable and timely detection of visceral malperfusion.
Chaihu-Longgu-Muli decoction improves sleep disorders by restoring orexin-A function in CKD mice
Authors: Cao Xin-li , Peng Xue-mei , Li Gong-bo , Ding Wei-sen , Wang Kai-zhen , Wang Xiao-lei , Xiong Yan-ying , Xiong Wei-jian , Li Fan , Song Min
Published: June 2023

Introduction

Chaihu-Longgu-Muli decoction (CLMD) is a well-used ancient formula originally recorded in the “Treatise on Febrile Diseases” written by the founding theorist of Traditional Chinese Medicine, Doctor Zhang Zhongjing. While it has been used extensively as a therapeutic treatment for neuropsychiatric disorders, such as insomnia, anxiety and dementia, its mechanisms remain unclear.

Methods

In order to analyze the therapeutic mechanism of CLMD in chronic renal failure and insomnia, An adenine diet-induced chronic kidney disease (CKD) model was established in mice, Furthermore, we analyzed the impact of CLMD on sleep behavior and cognitive function in CKD mice, as well as the production of insomnia related regulatory proteins and inflammatory factors.

Results

CLMD significantly improved circadian rhythm and sleep disturbance in CKD mice. The insomnia related regulatory proteins, Orexin, Orexin R1, and Orexin R2 in the hypothalamus of CKD mice decreased significantly, while Orexin and its receptors increased remarkably after CLMD intervention. Following administration of CLMD, reduced neuron loss and improved learning as well as memory ability were observed in CKD mice. And CLMD intervention effectively improved the chronic inflflammatory state of CKD mice.

Discussion

Our results showed that CLMD could improve sleep and cognitive levels in CKD mice. The mechanism may be related to the up-regulation of Orexin-A and increased phosphorylation level of CaMKK2/AMPK, which further inhibits NF-κB downstream signaling pathways, thereby improving the disordered inflammatory state in the central and peripheral system. However, More research is required to confirm the clinical significance of the study.
It starts from home? Explaining environmentally responsible resource and waste management
Authors: Brož David , Čábelková Inna , Hlaváček Martin , Smutka Luboš , Procházka Petr
Published: June 2023

Resource and waste management are indispensable to environmentally conscious action and a large part of EU Green politics. Little is known about factors affecting individual propensity for resource and waste management. The article examines the effects of environmental concerns, perceptions of climate change, preferences for EU integration, and media exposure (traditional and new) on the propensity to save resources and waste management employing a representative sample of 904 respondents in the Czech Republic. Methodologically we rely on principal component analysis, correlations, and a set of ordinal regression analyses. The results suggest that environmental and climate concerns increase the propensity to save resources and separate waste. The preferences for EU integration and media exposure were unrelated to saving resources and waste management, except exposure to online news, which negatively affected the environmentally motivated reduction of unnecessary car trips. The results imply immense consequences on the conceptual and policy-making levels. On the conceptual level the results suggest, that the mass media stopped to fulfill its developmental and persuasive functions, as generally people do not relate their pro-environmental behavior to the mass media exposure. From the policy-making perspective the mass media proves to be a poor resource for the pro-environmental actions as in case of social networks the role of mass media on waste management proved negative. We also suggest that saving resources and waste management stopped to be a topic of political and media influence but transferred to the domain of personal values and economic decisions.
Agricultural socialized services to stimulate the green production behavior of smallholder farmers: the case of fertilization of rice production in south China
Authors: Shi Fang , Cai Baozhong , Meseretchanie Abate , Geremew Betelhemabraham , Huang Yuangji
Published: June 2023

Introduction: This study investigates the impact of Agricultural Socialized Services (ASSs) on the green production behavior (GPB) of smallholder farmers in the main rice production region of southern China. The research aims to address the gap in understanding the relationship between ASSs and the adoption of sustainable agricultural practices by smallholder farmers.

Methodology: Data was collected from 741 smallholder farmers in Hunan, Jiangxi, and Zhejiang provinces using a structured questionnaire. A probit model was employed to examine the relationship between ASSs and smallholder farmers’ GPB.

Results and Discussion: The study revealed that ASSs have a significant and positive impact on smallholder farmers’ GPB. Farmers who received ASSs tended to adopt more sustainable agricultural practices such as using organic fertilizer and soil-tested formula fertilizer. The findings of this study have important implications for policymakers. The results suggest that policymakers should prioritize the development of services to agricultural producers and strengthen Agricultural Service Systems. This can be achieved through optimizing the public administration service system, establishing joint service organizations, and creating a good financial and legal service environment. By doing so, policymakers can promote the adoption of sustainable agricultural practices and the overall development of the agricultural sector.
Bispecific antibodies targeting CTLA-4: game-changer troopers in cancer immunotherapy
Authors: Farhangnia Pooya , Ghomi Shamim Mollazadeh , Akbarpour Mahzad , Delbandi Ali-Akbar
Published: June 2023

Antibody-based cancer immunotherapy has become a powerful asset in the arsenal against malignancies. In this regard, bispecific antibodies (BsAbs) are a ground-breaking novel approach in the therapy of cancers. Recently, BsAbs have represented a significant advancement in improving clinical outcomes. BsAbs are designed to target two different antigens specifically. Over a hundred various BsAb forms currently exist, and more are constantly being manufactured. An antagonistic regulator of T cell activation is cytotoxic T lymphocyte-associated protein 4 (CTLA-4) or CD152, a second counter-receptor for the B7 family of co-stimulatory molecules was introduced in 1996 by Professor James P. Allison and colleagues. Contrary to the explosive success of dual immune checkpoint blockade for treating cancers, a major hurdle still yet persist is that immune-related adverse events (irAEs) observed by combining immune checkpoint inhibitors (ICIs) or monoclonal antibodies such as ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1). A promising strategy to overcome this hurdle is using BsAbs. This article will summarize BsAbs targeting CTLA-4, their applications in cancer immunotherapy, and relevant clinical trial advances. We will also discuss the pre-clinical rationale for using these BsAbs, and provide the current landscape of the field.