bluuebunny/crossref_metadata_2025 huggingface dataset:
Solvent-Free Microwave Extraction of Thymus mastichina Essential Oil: Influence on Their Chemical Composition and on the Antioxidant and Antimicrobial Activities
Authors: Araujo André R. T. S. , Périno Sandrine , Fernandez Xavier , Cunha Cassandra , Rodrigues Márcio , Ribeiro Maximiano P. , Jordao Luisa , Silva Lúcia A. , Rodilla Jesus , Coutinho Paula , Chemat Farid
Published: July 2021

Solvent-free microwave extraction (SFME) is a combination of microwave heating and dry distillation performed at atmospheric pressure without the addition of water or organic solvents that has been proposed as a green method for the extraction of essential oils from aromatic and medicinal herbs. In this work, SFME and the conventional techniques of steam distillation (SD) and hydrodistillation (HD) were compared with respect to the extraction and antioxidant and antimicrobial activities of Thymus mastichina essential oil. The main constituent of essential oils obtained using different methods was 1,8-cineole (eucalyptol). The results showed that the essential oils extracted by means of SFME in 30 min were quantitatively (yield) and qualitatively (aromatic profile) similar to those obtained using conventional HD over 120 min. In addition, SFME generates less waste and less solvent, consumes less energy, and provides a higher yield for a shorter extraction time, which is advantageous for the extraction of the T. mastichina essential oil compared to SD. The antioxidant and antimicrobial activities of the T. mastichina essential oil obtained from either SFME or conventional extraction methods (SD or HD) showed a similar pattern. Large-scale experiments using this SFME procedure showed a potential industrial application.
Chitosan as Valuable Excipient for Oral and Topical Carvedilol Delivery Systems
Authors: Sip Szymon , Paczkowska-Walendowska Magdalena , Rosiak Natalia , Miklaszewski Andrzej , Grabańska-Martyńska Katarzyna , Samarzewska Karolina , Cielecka-Piontek Judyta
Published: July 2021

Chitosan is a valued excipient due to its biocompatibility properties and increasing solubility of poorly water-soluble drugs. The research presented in this paper concerns the preparation of binary combinations of chitosan (deacetylated chitin) with carvedilol (beta-blocker) to develop a formulation with a modified carvedilol release profile. As part of the research, six physical mixtures of chitosan with carvedilol were obtained and identified by spectral (PXRD, FT-IR, and Raman), thermal (DSC), and microscopic (SEM) methods. The next stage of the research estimated the profile changes and the dissolution rate for carvedilol in the obtained drug delivery systems; the reference sample was pure carvedilol. The studies were conducted at pH = 1.2 and 6.8, simulating the gastrointestinal tract conditions. Quantitative changes of carvedilol were determined using the developed isocratic UHPLC-DAD method. Established apparent permeability coefficients proved the changes in carvedilol’s permeability after introducing a drug delivery system through membranes simulating the gastrointestinal tract and skin walls. A bioadhesive potential of carvedilol–chitosan systems was confirmed using the in vitro model. The conducted research and the obtained results indicate a significant potential of using chitosan as an excipient in modern oral or epidermal drug delivery systems of carvedilol.
Selective Moonlighting Cell-Penetrating Peptides
Authors: Morán-Torres Rafael , Castillo González David A. , Durán-Pastén Maria Luisa , Aguilar-Maldonado Beatriz , Castro-Obregón Susana , Del Rio Gabriel
Published: July 2021

Cell penetrating peptides (CPPs) are molecules capable of passing through biological membranes. This capacity has been used to deliver impermeable molecules into cells, such as drugs and DNA probes, among others. However, the internalization of these peptides lacks specificity: CPPs internalize indistinctly on different cell types. Two major approaches have been described to address this problem: (i) targeting, in which a receptor-recognizing sequence is added to a CPP, and (ii) activation, where a non-active form of the CPP is activated once it interacts with cell target components. These strategies result in multifunctional peptides (i.e., penetrate and target recognition) that increase the CPP’s length, the cost of synthesis and the likelihood to be degraded or become antigenic. In this work we describe the use of machine-learning methods to design short selective CPP; the reduction in size is accomplished by embedding two or more activities within a single CPP domain, hence we referred to these as moonlighting CPPs. We provide experimental evidence that these designed moonlighting peptides penetrate selectively in targeted cells and discuss areas of opportunity to improve in the design of these peptides.
Salinomycin-Based Drug Delivery Systems: Overcoming the Hurdles in Cancer Therapy
Authors: Tefas Lucia Ruxandra , Barbălată Cristina , Tefas Cristian , Tomuță Ioan
Published: July 2021

Cancer stem cells (CSCs) are reportedly responsible for the initiation and propagation of cancer. Since CSCs are highly resistant to conventional chemo- and radiotherapy, they are considered the main cause of cancer relapse and metastasis. Salinomycin (Sali), an anticoccidial polyether antibiotic, has emerged as a promising new candidate for cancer therapy, with selective cytotoxicity against CSCs in various malignancies. Nanotechnology provides an efficient means of delivering Sali to tumors in view of reducing collateral damage to healthy tissues and enhancing the therapeutic outcome. This review offers an insight into the most recent advances in cancer therapy using Sali-based nanocarriers.
The Impact of the Preparation Method on the Properties of Orodispersible Films with Aripiprazole: Electrospinning vs. Casting and 3D Printing Methods
Authors: Łyszczarz Ewelina , Brniak Witold , Szafraniec-Szczęsny Joanna , Majka Tomasz M. , Majda Dorota , Zych Marta , Pielichowski Krzysztof , Jachowicz Renata
Published: July 2021

Orodispersible films (ODFs) address the needs of pediatric and geriatric patients and people with swallowing difficulties due to fast disintegration in the mouth. Typically, they are obtained using the solvent casting method, but other techniques such as 3D printing and electrospinning have already been investigated. The decision on the manufacturing method is of crucial importance because it affects film properties. This study aimed to compare electrospun ODFs containing aripiprazole and polyvinyl alcohol with films prepared using casting and 3D printing methods. Characterization of films included DSC and XRD analysis, microscopic analysis, the assessment of mechanical parameters, disintegration, and dissolution tests. Simplified stability studies were performed after one month of storage. All prepared films met acceptance criteria for mechanical properties. Electrospun ODFs disintegrated in 1.0 s, which was much less than in the case of other films. Stability studies have shown the sensitivity of electrospun films to the storage condition resulting in partial recrystallization of ARP. These changes negatively affected the dissolution rate, but mechanical properties and disintegration time remained at a desirable level. The results demonstrated that electrospun fibers are promising solutions that can be used in the future for the treatment of patients with swallowing problems.
Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical Applications
Authors: Nicu Raluca , Ciolacu Florin , Ciolacu Diana E.
Published: July 2021

Nanocelluloses (NCs), with their remarkable characteristics, have proven to be one of the most promising “green” materials of our times and have received special attention from researchers in nanomaterials. A diversity of new functional materials with a wide range of biomedical applications has been designed based on the most desirable properties of NCs, such as biocompatibility, biodegradability, and their special physicochemical properties. In this context and under the pressure of rapid development of this field, it is imperative to synthesize the successes and the new requirements in a comprehensive review. The first part of this work provides a brief review of the characteristics of the NCs (cellulose nanocrystals—CNC, cellulose nanofibrils—CNF, and bacterial nanocellulose—BNC), as well as of the main functional materials based on NCs (hydrogels, nanogels, and nanocomposites). The second part presents an extensive review of research over the past five years on promising pharmaceutical and medical applications of nanocellulose-based materials, which have been discussed in three important areas: drug-delivery systems, materials for wound-healing applications, as well as tissue engineering. Finally, an in-depth assessment of the in vitro and in vivo cytotoxicity of NCs-based materials, as well as the challenges related to their biodegradability, is performed.
Spectroscopic Measurement of Methylene Blue Distribution in Organs and Tissues of Hamadryas Baboons during Oral Administration
Authors: Kozlikina Elizaveta I. , Pominova Daria V. , Ryabova Anastasia V. , Efendiev Kanamat T. , Skobeltsin Aleksei S. , Rudenko Natalia S. , Kulik Olga G. , Muhametzyanova Evgeniya I. , Karal-ogly Dzina D. , Zhemerikin Gleb A. , Bulgin Dmitry V. , Shiryaev Artem A. , Reshetov Igor V. , Loschenov Victor B.
Published: July 2021

New research on Methylene Blue (MB), carried out in 2020, shows that it can be an effective antiviral drug as part of COVID-19 treatment. According to the research findings, MB has potential as a direct antiviral drug for the prevention and treatment of COVID-19 in the first stages of the disease. However, the MB accumulation by various types of tissues, as well as by immune cells, has not been previously studied. Therefore, the objective of this study was to obtain spectral data on the interstitial distribution of the administered drug in endothelial tissues in primates. The data on interstitial MB distribution obtained by spectroscopic measurement at both macro- and microlevels during oral administration to Hamadryas baboon individuals demonstrate that MB accumulates in mucous membranes of gastrointestinal tract and the tissues of the respiratory, cardiovascular, immune, and nervous systems. Additionally, it was found that MB was present in lung and brain myeloid cells in significant concentrations, which makes it potentially useful for protection from autoimmune response (cytokine storm) and as a tool for the correction of immunocompetent cells’ functional state during laser irradiation. Since the cytokine storm starts from monocytic cells during SARS-CoV-2 cellular damage and since tumor-associated macrophages can significantly alter tumor metabolism, accumulation of MB in these cells provides a reason to conclude that the immune response correction in COVID-19 patients and change in macrophages phenotype can be achieved by deactivation of inflammatory macrophages in tissues with MB using laser radiation of red spectral range.
Mercury-Induced Phytotoxicity and Responses in Upland Cotton (Gossypium hirsutum L.) Seedlings
Authors: Mei Lei , Zhu Yueyi , Zhang Xianwen , Zhou Xiujuan , Zhong Zhentao , Li Huazu , Li Yingjun , Li Xiaohu , Daud Muhammad Khan , Chen Jinhong , Zhu Shuijin
Published: July 2021

Cotton is a potential and excellent candidate to balance both agricultural production and remediation of mercury-contained soil, as its main production fiber hardly involves into food chains. However, in cotton, there is known rarely about the tolerance and response to mercury (Hg) environments. In this study, the biochemical and physiological damages, in response to Hg concentrations (0, 1, 10, 50 and 100 µM), were investigated in upland cotton seedlings. The results on germination of cottonseeds indicated the germination rates were suppressed by high Hg levels, as the decrease of percentage was more than 10% at 1000 µM Hg. Shoots and roots’ growth were significantly inhibited over 10 µM Hg. The inhibitor rates (IR) in fresh weight were close in values between shoots and roots, whereas those in dry weight the root growth were more obviously influenced by Hg. In comparison of organs, the growth inhibition ranked as root > leaf > stem. The declining of translocation factor (TF) opposed the Hg level as even low to 0.05 at 50 µM Hg. The assimilation in terms of photosynthesis, of cotton plants, was affected negatively by Hg, as evidenced from the performances on pigments (chlorophyll a and b) and gas exchange (Intercellular CO2 concentration (Ci), CO2 assimilation rate (Pn) and stomatal conductance (Gs)). Sick phenotypes on leaf surface included small white zone, shrinking and necrosis. Membrane lipid peroxidation and leakage were Hg dose-dependent as indicated by malondialdehyde (MDA) content and relative conductivity (RC) values in leaves and roots. More than 10 µM Hg damaged antioxidant enzyme system in both leaves and roots (p < 0.05). Concludingly, 10 µM Hg post negative consequences to upland cotton plants in growth, physiology and biochemistry, whereas high phytotoxicity and damage appeared at more than 50 µM Hg concentration.
Trait-Environment Relationships Reveal the Success of Alien Plants Invasiveness in an Urbanized Landscape
Authors: El-Barougy Reham F. , Dakhil Mohammed A. , Abdelaal Mohamed , El-Keblawy Ali , Bersier Louis-Félix
Published: July 2021

Urban areas are being affected by rapidly increasing human-made pressures that can strongly homogenize biodiversity, reduce habitat heterogeneity, and facilitate the invasion of alien species. One of the key concerns in invaded urban areas is comparing the trait–environment relationships between alien and native species, to determine the underlying causes of invasiveness. In the current study, we used a trait–environment dataset of 130 native plants and 33 alien plants, recorded in 100 plots covering 50 urban areas and 50 non-urban ones in an urbanization gradient in the arid mountainous Saint-Katherine protected area in Egypt. We measured eleven morphological plant traits for each plant species and ten environmental variables in each plot, including soil resources and human-made pressures, to construct trait–environment associations using a fourth-corner analysis. In addition, we measured the mean functional and phylogenetic distances between the two species groups along an urbanization gradient. Our results revealed strongly significant relationships of alien species traits with human-made pressures and soil resources in urban areas. However, in non-urban areas, alien species traits showed weak and non-significant associations with the environment. Simultaneously, native plants showed consistency in their trait–environment relationships in urban and non-urban areas. In line with these results, the functional and phylogenetic distances declined between the aliens and natives in urban areas, indicating biotic homogenization with increasing urbanization, and increased in non-urban areas, indicating greater divergence between the two species groups. Thereby, this study provided evidence that urbanization can reveal the plasticity of alien species and can also be the leading cause of homogenization in an arid urban area. Future urban studies should investigate the potential causes of taxonomic, genetic, and functional homogenization in species composition in formerly more diverse urbanized areas.
Comparative Effects of Different Light Sources on the Production of Key Secondary Metabolites in Plants In Vitro Cultures
Authors: Hashim Mariam , Ahmad Bushra , Drouet Samantha , Hano Christophe , Abbasi Bilal Haider , Anjum Sumaira
Published: July 2021

Plant secondary metabolites are known to have a variety of biological activities beneficial to human health. They are becoming more popular as a result of their unique features and account for a major portion of the pharmacological industry. However, obtaining secondary metabolites directly from wild plants has substantial drawbacks, such as taking a long time, posing a risk of species extinction owing to over-exploitation, and producing a limited quantity. Thus, there is a paradigm shift towards the employment of plant tissue culture techniques for the production of key secondary metabolites in vitro. Elicitation appears to be a viable method for increasing phytochemical content and improving the quality of medicinal plants and fruits and vegetables. In vitro culture elicitation activates the plant’s defense response and increases the synthesis of secondary metabolites in larger proportions, which are helpful for therapeutic purposes. In this respect, light has emerged as a unique and efficient elicitor for enhancing the in vitro production of pharmacologically important secondary metabolites. Various types of light (UV, fluorescent, and LEDs) have been found as elicitors of secondary metabolites, which are described in this review.
Cost-Effective Modern Chemical Sensor System for Soil Macronutrient Analysis Applied to Thai Sustainable and Precision Agriculture
Authors: Apichai Sutasinee , Saenjum Chalermpong , Pattananandecha Thanawat , Phojuang Kitti , Wattanakul Siraprapa , Kiwfo Kanokwan , Jintrawet Attachai , Grudpan Kate
Published: July 2021

A modern chemical sensor system (M-CSS) was developed for the cost-effective chemical analysis of Thai precision and sustainable agriculture (TPSA), which is suitable in rural Thailand and elsewhere. The aim of this study was to achieve precision and sustainable agriculture (P-SA). The M-CSS functions according to the International Union of Pure and Applied Chemistry (IUPAC) definition and incorporates information and communication technologies (ICTs). The developed chemical sensor in the M-CSS is based on a colorimetric determination by a smart device/smartphone. Additionally, the preparation of soil samples was investigated. Soil samples of optimal conditions were extracted using an acid extractant in the ratio of one to two (extract to soil sample). Then, phosphate-phosphorous and potassium were detected with the M-CSS, which showed an excellent correlation with the standard reference methods. Interestingly, it is noteworthy that the at-site analysis of the developed method could detect a greater nitrate-nitrogen content than that of the standard reference method. The developed cost-effective analysis for the plant macronutrient content in the soil, including nitrate-nitrogen, phosphate-phosphorous, and potassium, was demonstrated for organic vegetable farms at the real P-SA research site in Northern Thailand. The obtained results can guide the management of the application of fertilizers. The proposed M-CSS exhibited the potential to be used for at-site soil macronutrient analysis and represents the starting point of Thai precision and sustainable agriculture (TPSA).
Temporal Changes of Adsorbed Layer Thickness and Electrophoresis of Polystyrene Sulfate Latex Particles after Long Incubation of Oppositely Charged Polyelectrolytes with Different Charge Densities
Authors: Doan Thi Hai Yen , Pham Tien Duc , Hunziker Johan , Hoang Thu Ha
Published: July 2021

The different desorption concepts of the two polyelectrolytes PTMA5M and PTMC5M, which have similar molecular weights and differ in the charge density on the polystyrene sulfate latex (PSL) particles by 25 times, and with various charge densities in a long incubation, were systematically investigated based on hydrodynamic adsorbed layer thickness (δH) and electrophoretic mobility (EPM) under two ionic strengths in the present study. Herein, in the case of highly charged polyelectrolyte PTMA5M, desorption continued for 4 h and re-adsorbing proceeded after a longer incubation time higher than 4 h. Meanwhile, in the case of lowly charged polyelectrolyte PTMC5M, an adsorption–desorption equilibrium was suggested to take into account the unchanging of both δH and EPM.
Improved Cell Morphology and Surface Roughness in High-Temperature Foam Injection Molding Using a Long-Chain Branched Polypropylene
Authors: Mendoza-Cedeno Steven , Kweon Mu Sung , Newby Sarah , Shivokhin Maksim , Pehlert George , Lee Patrick C.
Published: July 2021

Long-chain branched polypropylene (LCB PP) has been used extensively to improve cell morphologies in foaming applications. However, most research focuses on low melt flow rate (MFR) resins, whereas foam production methods such as mold-opening foam injection molding (MO-FIM) require high-MFR resins to improve processability. A systematic study was conducted comparing a conventional linear PP, a broad molecular weight distribution (BMWD) linear PP, and a newly developed BMWD LCB PP for use in MO-FIM. The effects of foaming temperature and molecular architecture on cell morphology, surface roughness, and mechanical properties were studied by utilizing two chemical blowing agents (CBAs) with different activation temperatures and varying packing times. At the highest foaming temperatures, BMWD LCB PP foams exhibited 887% higher cell density, 46% smaller cell sizes, and more uniform cell structures than BWMD linear PP. Linear PP was found to have a surface roughness 23% higher on average than other resins. The BMWD LCB PP was found to have increased flexural modulus (44%) at the cost of decreased toughness (−88%) compared to linear PP. The branched architecture and high molecular weight of the BMWD LCB PP contributed to improved foam morphologies and surface quality in high-temperature MO-FIM conditions.
Effect of Process Parameters on Energy Consumption, Physical, and Mechanical Properties of Fused Deposition Modeling
Authors: Enemuoh Emmanuel U. , Duginski Stefan , Feyen Connor , Menta Venkata G.
Published: July 2021

The application of the fused deposition modeling (FDM) additive manufacturing process has increased in the production of functional parts across all industries. FDM is also being introduced for industrial tooling and fixture applications due to its capabilities in building free-form and complex shapes that are otherwise challenging to manufacture by conventional methods. However, there is not yet a comprehensive understanding of how the FDM process parameters impact the mechanical behavior of engineered products, energy consumption, and other physical properties for different material stocks. Acquiring this information is quite a complex task, given the large variety of possible combinations of materials–additive manufacturing machines–slicing software process parameters. In this study, the knowledge gap is filled by using the Taguchi L27 orthogonal array design of experiments to evaluate the impact of five notable FDM process parameters: infill density, infill pattern, layer thickness, print speed, and shell thickness on energy consumption, production time, part weight, dimensional accuracy, hardness, and tensile strength. Signal-to-noise (S/N) ratio analysis and analysis of variance (ANOVA) were performed on the experimental data to quantify the parameters’ main effects on the responses and establish an optimal combination for the FDM process. The novelty of this work is the simultaneous evaluation of the effects of the FDM process parameters on the quality performances because most studies have considered one or two of the performances alone. The study opens an opportunity for multiobjective function optimization of the FDM process that can be used to effectively minimize resource consumption and production time while maximizing the mechanical and physical characteristics to fit the design requirements of FDM-manufactured products.
The Influence of Local Strain Distribution on the Effective Electrical Resistance of Carbon Black Filled Natural Rubber
Authors: Harea E. , Datta S. , Stěnička M. , Maloch J. , Stoček R.
Published: July 2021

A monotonous relation between strain and measured electric resistance is highly appreciated in stretchable elastomer sensors. In real-life application the voids or technological holes of strained samples often induce non-homogeneous local strain. The present article focused on studying the effect of non-homogeneous local strain on measured direct current (DC) effective electric resistance (EER) on samples of natural rubber (NR), reinforced with 50, 60 and 70 phr of carbon black (CB). Samples were imparted geometrical inhomogeneities to obtain varied local strains. The resulting strain distribution was analyzed using Digital Image Correlation (DIC). EER exhibited a well-detectable influence of locations of inhomogeneities. Expectedly, the EER globally decreased with an increase in CB loading, but showed a steady increase as a function of strain for 50 and 60 phr over the complete testing protocol. Interestingly, for 70 phr of CB, under the same testing conditions, an alternating trend in EER was encountered. This newly observed behavior was explained through a novel hypothesis—“current propagation mode switching phenomenon”. Finally, experimentally measured EERs were compared with the calculated ones, obtained by summing the global current flow through a diversity of strain dependent resistive domains.
Experimental Investigation of the Rapid Fabrication of Micron and Submicron Structures on Polymers Utilizing Ultrasonic Assisted Embossing
Authors: Zhu Yongyong , Bengsch Sebastian , Zheng Lei , Long Yangyang , Roth Bernhard Wilhelm , Wurz Marc Christopher , Twiefel Jens , Wallaschek Jörg
Published: July 2021

Small-scale optical components with micron or submicron features have grown in popularity in recent years. High-quality, high-efficient, and cost-effective processing approaches for polymer optics mass production are an urgent need. In this study, ultrasonic vibration will be introduced in embossing. The major advantage is that the required energy can be provided for process times ranging from a few hundred milliseconds to a few seconds, and that the process energy is provided at exactly the required location so that the structures in the surrounding area are not affected. Due to the strong correlation between electrical impedance and the temperature of the material, a novel impedance-based control strategy has been utilized for precisely controlling ultrasonic vibration during the embossing process. The investigation used two types of stamps with grating line widths of 4 µm and 500 nm, respectively. As a result, an embossing time of less than a few seconds was accomplished and a uniform embossed surface with an average fill rate of more than 75% could be achieved.
Effect of a Powder Mould in the Post-Process Thermal Treatment of ABS Parts Manufactured with FDM Technology
Authors: Lluch-Cerezo Joaquín , Benavente Rut , Meseguer María Desamparados , García-Manrique Juan Antonio
Published: July 2021

The post-process thermal treatment of thermoplastics improves their mechanical properties, but causes deformations in parts, making them unusable. This work proposes a powder mould to prevent dimensional part deformation and studies the influence of line building direction in part deformations in a post-process thermal treatment of 3D printed polymers. Two sets of ABS (acrylonitrile butadiene styrene) test samples manufactured by fused deposition modelling (FDM) in six different raster directions have been treated and evaluated. One set has been packed with a ceramic powder mould during thermal treatment to evaluate deformations and mould effectiveness. Thermogravimetric tests have been carried out on ABS samples, concluding that the thermal treatment of the samples does not cause degradations in the polymeric material. An analysis of variance (ANOVA) was performed to study internal building geometry and mould influence on part deformation after the thermal treatment. It can be concluded that powder mould considerably reduces dimensional deformations during the thermal treatment process, with length being the most affected dimension for deformation. Attending to the length, mould effectiveness is greater than 80% in comparison to non-usage of moulding, reaching 90% when the building lines are in the same direction as the main part.
Conjugated Polymer Films Having a Uniaxial Molecular Orientation and Network Structure Prepared by Electrochemical Polymerization in Liquid Crystals
Authors: Dong Jiuchao , Nimori Shigeki , Goto Hiromasa
Published: July 2021

A new method for fabricating conjugated polymer films was developed using electrochemical polymerization in liquid crystals and magnetic orientation. A uniaxial main chain orientation and a crosslinked network structure were achieved with this method. By employing eight types of monomers, the influence of the crosslinking for the film was investigated. The crosslinking was found to improve the solvent resistance of the conjugated polymer films. This new method is expected to be useful in various applications, such as high-powered organic electronic devices with durability.
Advanced Kinetic Modeling of Bio-co-polymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Production Using Fructose and Propionate as Carbon Sources
Authors: Duvigneau Stefanie , Dürr Robert , Behrens Jessica , Kienle Achim
Published: July 2021

Biopolymers are a promising alternative to petroleum-based plastic raw materials. They are bio-based, non-toxic and degradable under environmental conditions. In addition to the homopolymer poly(3-hydroxybutyrate) (PHB), there are a number of co-polymers that have a broad range of applications and are easier to process in comparison to PHB. The most prominent representative from this group of bio-copolymers is poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). In this article, we show a new kinetic model that describes the PHBV production from fructose and propionic acid in Cupriavidus necator (C. necator). The developed model is used to analyze the effects of process parameter variations such as the CO2 amount in the exhaust gas and the feed rate. The presented model is a valuable tool to improve the microbial PHBV production process. Due to the coupling of CO2 online measurements in the exhaust gas to the biomass production, the model has the potential to predict the composition and the current yield of PHBV in the ongoing process.
Effect of Parinari curatellifolia Peel Flour on the Nutritional, Physical and Antioxidant Properties of Biscuits
Authors: Ramashia Shonisani Eugenia , Mamadisa Felicia Matshepho , Mashau Mpho Edward
Published: July 2021

This study investigated the impact of Parinari curatellifolia peel flour on the nutritional, physical and antioxidant properties of formulated biscuits. Biscuits enriched with 5%, 10%, 15% and 20% of Parinari (P). curatellifolia peel flour were formulated and characterised. Thermal, physicochemical, polyphenolic compounds and antioxidant properties of flour and biscuits were determined. The incorporation of P. curatellifolia peel flour significantly increased (p < 0.05) thermal properties (onset, peak and conclusion temperatures) of flour. However, enthalpy of gelatinisation, viscosity and pH of flour samples decreased. Nutritional analysis revealed an increase in ash (0.74% to 2.23%) and crude fibre contents (0.39% to 2.95%) along with an increase of P. curatellifolia peel flour levels. Protein content and carbohydrates decreased while moisture content was insignificantly affected by the addition of P. curatellifolia peel flour. The L*, b* values and whiteness index of formulated biscuits decreased while parameter a* value (10.76 to 21.89) and yellowness index (69.84 to 102.71) decreased. Physical properties such as diameter (3.57 mm to 3.97 mm), spread ratio (2.67 to 3.45) and hardness (1188.13 g to 2432.60 g) increased with the inclusion levels of peel flour while weight and thickness decreased. The inclusion of P. curatellifolia improved the polyphenolic compounds and antioxidant activity of biscuits with values of total flavonoids content ranging from 0.028 to 0.104 mg CE/g, total phenolic content increasing from 20.01 mg to 48.51 mg GAE/g, ferric reducing antioxidant power (FRAP) increasing from 108.33 mg to 162.67 mg GAE/g and DPPH (2,2-diphenyl-1-picrylhydrazyl) from 48.70% to 94.72%. These results lead to the recommendation of the utilisation of P. curatellifolia peel flour to enhance the nutritional value, polyphenolic compounds and antioxidant activity of bakery products such as biscuits.
A Hybrid Intelligent Fault Diagnosis Strategy for Chemical Processes Based on Penalty Iterative Optimization
Authors: Yao Yuman , Zhang Jiaxin , Luo Wenjia , Dai Yiyang
Published: July 2021

Process fault is one of the main reasons that a system may appear unreliable, and it affects the safety of a system. The existence of different degrees of noise in the industry also makes it difficult to extract the effective features of the data for the fault diagnosis method based on deep learning. In order to solve the above problems, this paper improves the deep belief network (DBN) and iterates the optimal penalty term by introducing a penalty factor, avoiding the local optimal situation of a DBN and improving the accuracy of fault diagnosis in order to minimize the impact of noise while improving fault diagnosis and process safety. Using the adaptive noise reduction capability of an adaptive lifting wavelet (ALW), a practical chemical process fault diagnosis model (ALW-DBN) is finally proposed. Then, according to the Tennessee–Eastman (TE) benchmark test process, the ALW-DBN model is compared with other methods, showing that the fault diagnosis performance of the enhanced DBN combined with adaptive wavelet denoising has been significantly improved. In addition, the ALW-DBN shows better performance under the influence of different noise levels in the acid gas absorption process, which proves its high adaptability to different noise levels.
Pandemic Analytics by Advanced Machine Learning for Improved Decision Making of COVID-19 Crisis
Authors: Demertzis Konstantinos , Taketzis Dimitrios , Tsiotas Dimitrios , Magafas Lykourgos , Iliadis Lazaros , Kikiras Panayotis
Published: July 2021

With the advent of the first pandemic wave of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), the question arises as to whether the spread of the virus will be controlled by the application of preventive measures or will follow a different course, regardless of the pattern of spread already recorded. These conditions caused by the unprecedented pandemic have highlighted the importance of reliable data from official sources, their complete recording and analysis, and accurate investigation of epidemiological indicators in almost real time. There is an ongoing research demand for reliable and effective modeling of the disease but also the formulation of substantiated views to make optimal decisions for the design of preventive or repressive measures by those responsible for the implementation of policy in favor of the protection of public health. The main objective of the study is to present an innovative data-analysis system of COVID-19 disease progression in Greece and her border countries by real-time statistics about the epidemiological indicators. This system utilizes visualized data produced by an automated information system developed during the study, which is based on the analysis of large pandemic-related datasets, making extensive use of advanced machine learning methods. Finally, the aim is to support with up-to-date technological means optimal decisions in almost real time as well as the development of medium-term forecast of disease progression, thus assisting the competent bodies in taking appropriate measures for the effective management of the available health resources.
Effect of Gas-Liquid Contact Intensification on Heat and Mass Transfer in Deflector and Rod Bank Desulfurization Spray Tower
Authors: Jin Yuzhen , Zhao Weida , Li Zeqing
Published: July 2021

The deflector and the rod bank are commonly used to optimize flue gas distribution in the original spray tower (OST) of a wet flue gas desulfurization system (WFGD). In this paper, the internal optimization mechanism of the deflector desulfurization spray tower (DST) and the rod bank desulfurization spray tower (RBST) are studied. Based on the Euler–Lagrange method, the standard k-ε turbulence model, an SO2 absorption model and a porous media model, the numerical simulation of the desulfurization spray tower is carried out with the verification of the model rationality. The results show that there are gas-liquid contact intensification effects in DST and RBST. Compared with OST, gas-liquid contact intensification enhances the heat and mass transfer effects of DST and RBST. The temperature difference between inlet and outlet of flue gas increased by 3.3 K and the desulfurization efficiency of DST increased by 1.8%; the pressure drop decreased by 37 Pa. In RBST, the temperature difference between the flue gas inlet and outlet increased by 5.3 K and the desulfurization efficiency increased by 3.6%; the pressure drop increased by 33 Pa.
Quantifying the Impact of Production Globalization through Application of the Life Cycle Inventory Methodology and Its Influence on Decision Making in Industry
Authors: Prado-Galiñanes Humberto. J. , Domingo Rosario
Published: July 2021

Industries are nowadays not only expected to produce goods and provide services, but also to do this sustainably. What qualifies a company as sustainable implies that its activities must be defined according to the social and ecological responsibilities that are meant to protect the society and the environment in which they operate. From now on, it will be necessary to consider and measure the impact of industrial activities on the environment, and to do so, one key parameter is the carbon footprint. This paper demonstrates the utility of the LCI as a tool for immediate application in industries. Its application shall facilitate decision making in industries while choosing amongst different scenarios to industrialize a certain product with the lowest environmental impact possible. To achieve this, the carbon footprint of a given product was calculated by applying the LCI method to several scenarios that differed from each other only in the supply-chain model. As a result of this LCI calculation, the impact of the globalization of a good’s production was quantified not only financially, but also environmentally. Finally, it was concluded that the LCI/LCA methodology can be considered as a fundamental factor in the new decision-making strategy that sustainable companies must implement while deciding on the business and industrial plan for their new products and services.
An Imperfect Production–Inventory Model with Mixed Materials Containing Scrap Returns Based on a Circular Economy
Authors: Su Rung-Hung , Weng Ming-Wei , Yang Chih-Te , Li Hsin-Ting
Published: July 2021

The implementation of scrap recovery activities has been shown to improve the financial performance of many firms, and this kind of circular economy (CE) is particularly evident in industries with green manufacturing (GM). In this paper, we consider an imperfect multiple-stage production system that manufactures paired products made from mixed materials containing scrap returns, in which the scrap returns are converted from defective products. The feed rates of scrap returns for two products are different, and the product with the higher feed rate is placed in the second order of the process to avoid unlimited accumulation of scrap returns. The proposed problem is formulated as a joint economic order quantity (EOQ) and economic production quantity (EPQ) model aimed at cost minimization. The decision variables of the proposed model include the production run time of two products, order quantity of new material, and the extent of investment in converted equipment. We also prove that the optimal solution exists uniquely and provide an algorithm for the computation of the optimal solution. Finally, a numerical example involving the pulp and paper manufacturing industry is provided to illustrate the solution process, and the results of its sensitivity analysis are also presented to show some managerial implications.
Combustion of Laser-Induced Individual Magnesium Microparticles under Natural Convection
Authors: Lin Chengyuan , Zhang Minqi , Wang Yue , Li Shengji , Huang Xuefeng , Xu Jiangrong , Pan Sunqiang
Published: July 2021

Metal magnesium (Mg) fuels have been widely used in rocket propellants. The combustion study on individual Mg microparticles is crucial to the in-depth unveiling of the combustion mechanism of Mg-based propellants. In this paper, a new experimental setup was proposed to directly observe the combustion of individual micron-sized Mg particles, based on laser ignition and microscopic high-speed cinematography. The combustion process of individual Mg microparticles could be directly and clearly observed by the apparatus at high temporal and spatial resolutions. Individual Mg microparticles took gas phase combustion, and mainly underwent four stages: expansion, melting, gasification, ignition, and combustion. The ignition delay time and total combustion time had an exponential decay on the particle diameter, and they had a linear decay on the ignition power density. The melting took a dominant role in the whole burnout time. The gas-phase combustion flame seemed thick, inhomogeneous, and ring-like structure. The combustion model of individual Mg microparticles was built through combining the experimental results with the SEM, XRD, XPS, and EDS analysis of original samples and combustion residues. This study will be beneficial to understand the combustion process and reveal the combustion mechanism of metal microparticles besides Mg.
Natural Convection and Entropy Generation of MgO/Water Nanofluids in the Enclosure under a Magnetic Field and Radiation Effects
Authors: Khetib Yacine , Alahmadi Ahmad Aziz , Alzaed Ali , Tahmasebi Ahamd , Sharifpur Mohsen , Cheraghian Goshtasp
Published: July 2021

The authors of the present paper sought to conduct a numerical study on the convection heat transfer, along with the radiation and entropy generation (EGE) of a nanofluids (NFs) in a two and three-dimensional square enclosure, by using the FVM. The enclosure contained a high-temperature blade in the form of a vertical elliptical quadrant in the lower corner of the enclosure. The right edge of the enclosure was kept at low temperature, while the other edges were insulated. The enclosure was subjected to a magnetic field (MGF) and could be adjusted to different angles. In this research, two laboratory relationships dependent on temperature and volume fraction were used to simulate thermal conductivity and viscosity. The variables of this problem were Ra, Ha, RAP, nanoparticle (NP) volume fraction, blade aspect ratio, enclosure angles, and MGF. Evaluating the effects of these variables on heat transfer rate (HTR), EGE, and Be revealed that increasing the Ra and reducing the Ha could increase the HTR and EGE. On the other hand, adding radiation HTR to the enclosure increased the overall HTR. Moreover, an augmentation of the volume fraction of magnesium oxide NPs led to an increased amount of HTR and EGE. Furthermore, any changes to the MGF and the enclosure angle imposed various effects on the HTR. The results indicated that an augmentation of the size of the blade increased and then decreased the HTR and the generated entropy. Finally, increasing the blade always increased the Be.
Application of Cylindrical Fin to Improve Heat Transfer Rate in Micro Heat Exchangers Containing Nanofluid under Magnetic Field
Authors: Khetib Yacine , Alahmadi Ahmad , Alzaed Ali , Jai Krishnan Suseel , Sharifpur Mohsen , Cheraghian Goshtasp
Published: July 2021

In this study, the convective mode heat transfer phenomena of bi-phase elasticoviscous (non-Newtonian) nanofluid is quantified by forcefully flowing it through a specially designed microchannel test section. The test section, which is rectangularly cross-sectioned and annexed internally with cylindrical needle ribs is numerically investigated by considering the walls to be maintained at a constant temperature, and to be susceptible to a magnetizing force field. The governing system-state equations are numerically deciphered using control volume procedure and SIMPLEC algorithm. With the Reynolds number (Re) varying in the turbulent range from 3000 to 11,000, the system-state equations are solved using the Eulerian–Eulerian monofluid Two-Phase Model (TPM). For the purpose of achieving an apt geometry based on the best thermo-hydraulic behavior, an optimization study must be mandatory. The geometry of the cylindrical rib consists of h (10 × 10−3, 15 × 10−3, 20 × 10−3), p (1.0, 1.5), and d (8 × 10−3, 10 × 10−3, 12 × 10−3), which, respectively, defines the height, pitch, and diameter of the obstacles, with the dimensions placed within the braces being quantified in mm. The results demonstrated that the magnetic field leads to an enhanced amount of average Nusselt number (Nuav) in contrast with the occurrence at B = 0.0. This is due to the that the magnetic field pushes nanoparticles towards the bottom wall. It was found that B = 0.5 T has the maximum heat transfer compared with the other magnetic fields. The channel with h = 15 μm height leads to the maximum value of Nuav at all studied Re for constant values of d and h. The channel with p = 1.5 μm results in the maximum value of Nuav at all studied Re for constant values of d and h. The microchannel with d = 8 μm, p = 1.5 μm, and h = 15 μm in the presence of the magnetic field with B = 0.5 T is the best geometry in the present work.
Exposure Assessment of Airborne Bacteria Emitted from Swine Manure Composting Plant
Authors: Kim Ki-Youn
Published: July 2021

This study was performed to investigate the distribution characteristics of airborne bacteria emitted from swine manure composting plants. The types of swine manure composting plants selected for the survey in this study were as follows: screw type, rotary type, and natural dry type. Mean levels of airborne bacteria in swine manure composting plants were 7428 (±1024) CFU m−3 for the screw type, 3246 (±1407) CFU m−3 for the rotary type, and 5232 (±1217) CFU m−3 for the natural dry type, respectively. Based on the results obtained from this study, the swine manure composting plant operated by screw type showed the highest concentration of airborne bacteria, followed by the natural dry type and rotary type. The monthly concentration of airborne bacteria was the highest in August and the lowest in November, regardless of the type of swine manure composting plant. The respirable size of airborne bacteria accounted for about 50% of the total. The ratio of respirable to the total quantity of airborne bacteria was 50%. The correlation relationships between airborne bacteria and environmental factors (temperature, relative humidity, particulate matters, and odor) were not found to be significant in the swine manure composting plants. The predominant genera of airborne bacteria identified were Micrococcus spp., Staphylococcus spp., Escherichia (E-coli) spp., Enterococcus spp., and Enterobacteriaceae spp.
Effect on Combustion Properties of Coal Treated by Microwave Irradiation Combined with Sodium Hydroxide Solution
Authors: Cai Chuanchuan , Ge Tao , Zhang Mingxu , Zhao Yuqi , Wu Chunhui , Han Jiaxuan
Published: July 2021

A Kentucky coal sample treated by microwave irradiation (MI) combined with sodium hydroxide solution was performed using a thermo-gravimetric analyzer (TGA) coupled to a Fourier transform infrared spectrometer (FTIR). The combustion properties and structural changes of coal under different conditions were investigated and compared. The results show that the desulfurization efficiency of coal samples increases with the increase of sodium hydroxide solution concentration. Microwave irradiation can significantly improve the desulfurization efficiency. The whole combustion process of the treated coal sample becomes longer; the combustion performance becomes worse. The total mass loss of coal treated samples is significantly reduced, and the temperature corresponding to the maximum weight loss rate decreases with the increase of sodium hydroxide concentration. The infrared spectra of the coal samples treated with microwave and 5% sodium hydroxide solution were basically unchanged, while the O containing groups and aromatic C-H groups increased in the coal samples treated with 20% sodium hydroxide solution.