bluuebunny/crossref_metadata_2025 huggingface dataset:
O consumo como experiência
Authors: Falcone Giulia
Published: January 2020

A moda de luxo e a gastronomia não foram invenções do século XIX. Vestimentas suntuosas e alimentos refinados eram habitualmente consumidos pelas cortes aristocráticas nos séculos XVII e XVIII. A grande diferença introduzida pelo século XIX, portanto, foi o banimento da restrição do consumo desses bens à classe aristocrática.

A possibilidade do acesso ao luxo e à gastronomia implica na necessidade do estabelecimento de novos critérios que garantam sua exclusividade à nova classe dominante. Esse preceito é traduzido em preços mais elevados, o que certifica não apenas a manutenção da restrição do consumo do luxo e da gastronomia à burguesia, como reforça a distinção da produção sofisticada desses bens ao modo de produção industrial em crescimento.

Entretanto, no século XX, especialmente a partir dos anos 1950, o desenvolvimento dos meios de reprodutibilidade técnica promove a massificação na produção de bens de luxo e artigos gastronômicos, equiparando-se cada vez mais à produção daquilo que é considerado banal. A partir de então, se a forma como são produzidos não demarca mais a diferenciação entre o simples e o refinado, é necessário que novas formas de consumo o façam.

Deste modo, a experiência do consumo assume uma posição de especial relevância, inclusive em comparação à forma de produção. Assim, não é mais a experiência da produção que confere ao bem de luxo ou ao artigo gastronômico a qualidade de exclusivo, mas a forma como são consumidos que garante a reprodução da sensação de exclusividade.

Este trabalho pretende discutir como se manifestam essas experiências de consumo do luxo e da gastronomia no século XXI. Será dada especial atenção às expressões que combinam a moda de luxo e a gastronomia a uma experiência estética, na qual se busca a desvinculação da reprodutibilidade técnica através da compreensão do consumo como um momento supra-histórico, em que é privilegiada a experiência sensorial do “aqui e agora”.
Revision and phylogenetic analysis of Chilicola sensu stricto (Hymenoptera: Colletidae) with the description of a new species
Authors: GIBBS JASON , PACKER LAURENCE
Published: January 2020

The bee subgenus Chilicola sensu stricto Spinola (Colletidae: Xeromelissinae) is revised. The male and female of Chilicola (Chilicola) luzmarieae Gibbs and Packer, new species are described based upon material from Chile. New descriptions are also provided for the five additional species of this subgenus. A key to species is provided. A phylogenetic analysis of the subgenus shows that Chilicola s. str. and Chilicola (Chilioediscelis) are each monophyletic and sister groups to one another.
Hydroporus neclae sp. n. from north-eastern Turkey, a new member of the memnonius-group of Hydroporus Clairville (Coleoptera: Dytiscidae)
Authors: ERMAN ÖMER K. , FERY HANS
Published: January 2020

Hydroporus neclae sp.n. is described from the Erzurum province in north-eastern Turkey. The species belongs to the Hydroporus memnonius-group. Its habitus and the shape of the median lobe are similar to those of H. longicornis Sharp, but the shape of the hind margins of the metacoxal processes are similar to those of H. melanarius Sturm. The male and female genitalia as well as several other characters of H. neclae sp.n. are figured and compared with those of these two other species. The key to species of the memnonius-group given in Fery (1999) is modified to include the new species and the relevant parts are presented.
Polistes (Polistella) wasps (Hymenoptera: Vespidae: Polistinae) from mountainous areas of northern Vietnam, with description of five new species
Authors: NGUYEN LIEN THI PHUONG , KOJIMA JUN-ICHI , SAITO FUKI
Published: January 2020

A total of 14 species of subgenus Polistella Ashmead 1904 of genus Polistes Latreille 1802 are recognized in the mountainous areas of northern Vietnam, the eastern margin of the eastern slope of the Himalayas. A key to these species is provided. Five new species are described: P. curcipunctum Nguyen, Kojima & Saito, sp. nov.; P. reliciniclypeus Nguyen, Kojima & Saito, sp. nov.; P. gilvus Nguyen, Kojima & Saito, sp. nov.; P. paco Nguyen, Kojima & Saito, sp. nov.; and P. clandestinus Nguyen, Kojima & Saito, sp. nov. The male of P. dawnae Dover & Rao is described for the first time. Nests of P. lepcha Cameron, P. dawnae Dover & Rao , P. reliciniclypeus and P.
Change of authorship of Aphodius and Oryctes to Hellwig, 1798 (Insecta: Coleoptera: Scarabaeidae)
Authors: ALONSO-ZARAZAGA MIGUEL ANGEL , KRELL FRANK-THORSTEN
Published: January 2020

The dung beetle genus Aphodius and the rhinoceros beetle genus Oryctes rank among the more widely used scientific insect names. Both have been attributed to Johann Karl Wilhelm Illiger who had introduced those names in his "Verzeichniss der Käfer Preussens" in 1798. The names are undisputed and stable. The discovery of a preview of Illiger’s book, published eight months earlier, prompts a change of authorship to Hellwig (1798) for both of these generic names.
Mirnapis ohloweni Packer and Dumesh, new species with notes on M. inca Urban (Hymenoptera: Apidae: Eucerini)
Authors: PACKER LAURENCE , DUMESH SHEILA
Published: January 2020

The bee genus Mirnapis is revised. Mirnapis ohloweni Packer and Dumesh new species, is described from East of Nazca, Peru and compared to both sexes of the type species, M. inca Urban, based upon material from northern Chile. Thus, the female of the genus is described for the first time. Both sexes of both species are illustrated and variation in some important characteristics noted. The new material permits a more detailed diagnosis of the genus. Michener’s (2007) key to South American Eucerini is modified to facilitate the identification the genus and Vivallo’s (2009) key to Chilean Eucerini is emended to permit identification of M. inca.
A new fossil Hybosoridae (Coleoptera: Scarabaeoidea) from the Yixian Formation of China
Authors: YAN ZHUO , BAI MING , REN DONG
Published: January 2020

Hybosoridae is a relatively small family of Scarabaeoidea, including five extant and one fossil subfamily (Ocampo & Ballerio 2006, Nikolajev 2007). Until now, 20 fossil species were known from five subfamilies: Anaidinae, Ceratocanthinae, Hybosorinae, Liparochrinae, and Mimaphodiinae (Ocampo & Ballerio 2006, Krell 2007, Nikolajev 2008, Nikolajev et al. 2010, Nikolajev 2010a, Nikolajev 2010b, Kirejtshuk et al. 2011). In this paper we describe Pulcherhybosorus tridentatus Yan, Bai, & Ren new genus and new species, from a nearly complete and well-preserved fossil. This fossil represents the first record of Hybosoridae from the Early Cretaceous Yixian Formation of Liutiaogou, Inner Mongolia in China. This significant finding tentatively confirms the presence of Hybosoridae during the Mesozoic in what is now China.
Revision of the genus Falsocaenia (Coleoptera: Lycidae)
Authors: BOCAKOVA MILADA , BACIAKOVA BARBORA , NASCIMENTO ELYNTON ALVES DO
Published: January 2020

The Neotropical genus Falsocaenia Pic, 1922 is revised. Two species Falsocaenia ecuadorensis sp. nov. and F.melanopteron sp. nov. are proposed as new to science. Idiopteron (F.) apicicorne (Pic, 1922) and Idiopteron (F.)aurantiacocostatum (Pic, 1932) are placed in the genus Falsocaenia, and consequently, Falsocaenia apicicornis (Pic, 1922)comb. n. and Falsocaenia aurantiacocostata (Pic, 1932) are proposed. Falsocaenia breveapicalis Pic, 1930 is consideredto be a younger subjective synonym of Falsocaenia decipiens (Gorham, 1884) and Falsocaenia callangana (Pic, 1922) issynonymized to F. longehumeralis (Pic, 1922). Falsocaenia nigripenne Pic, 1934 is transferred to the genus Idiopteron andIdiopteron nigripenne (Pic, 1934) comb. n. is proposed. Simultaneously, lectotype of Falsocaenia aurantiacocostata is designated. Illustrations of diagnostic characters are included and a key to Falsocaenia species is given.
Seven new species of the genus Chimarra Stephens (Trichoptera: Philopotamidae) from India
Authors: PANDHER MANPREET SINGH , SAINI MALKIAT SINGH
Published: January 2020

Seven new species belonging to the genus Chimarra are added to the Trichoptera fauna of India. Newly described speciesinclude Chimarra lakhwinderae, C. rifati, C. nakkiensis, C. mawsmaiensis, C. sikkimensis, C. rongliensis, and C. soloi.Males of these species are distinguishable from each other and from previously known species by consistent variation in the structure of the inferior appendages, tergite X and the phallic apparatus.
Ten new species of the genus Phortica from the Afrotropical and Oriental regions (Diptera: Drosophilidae)
Authors: CHEN HONGWEI , MÁCA JAN
Published: January 2020

Ten new species of the genus Phortica are described from the Afrotropical and Oriental regions: P. (Allophortica)chingolaensis Chen & Máca, sp. nov., P. (Ashima) eseta Chen, sp. nov., P. (Ashima) mediarista Chen, sp. nov., P. (Ashima)nakanoi Chen, sp. nov., P. (Ashima) biclavata Chen, sp. nov., P. (Phortica) ancistria Chen, sp. nov., P. (Phortica)monoceaena Chen, sp. nov., P. (Phortica) dirhopala Chen, sp. nov., P. (Phortica) ryukyuensis Chen, sp. nov. and P. (Phortica) sumatraensis Chen, sp. nov. A species list of the genus Phortica is provided.
Three new species of the louse genus Saemundssonia (Insecta: Phthiraptera: Philopteridae)
Authors: PALMA RICARDO L.
Published: January 2020

I describe and illustrate three new species of chewing lice in the genus Saemundssonia, collected from seabirds in NewZealand, the Galápagos and other islands of the Pacific Ocean. They are: Saemundssonia (Saemundssonia) albatrossa n.sp. from Phoebetria palpebrata, Thalassarche chrysostoma, and Thalassarche impavida; Saemundssonia(Saemundssonia) creagrusa n. sp. from Creagrus furcatus; and Saemundssonia (Saemundssonia) gygisa n. sp. from Gygis alba candida.
The Palaeotropical genus Craspedothrips, with new species from Africa and Malaysia (Thysanoptera, Thripinae)
Authors: MOUND L. A. , MASUMOTO M. , OKAJIMA S.
Published: January 2020

An identification key is provided to 10 species recognised in the genus Craspedothrips, including three new species, C. malaysiae from Malaysia, and C. nyanzai, C. poecilus, and C. reticulatus from East Africa. Plesiopsothrips zurstrasseni Bournier et al. is considered a new synonym of C. hargreavesi, and Plesiopsothrips carvalhoi Bournier a new synonym of C. xanthocerus. One oriental species, C. antennalis Karny, is newly recorded from Australia. Little is known of the biology of most species, but C. antennatus and C. xanthocerus are both recorded in association with Hemileia vastatrix on the leaves of Coffea species (Rubiaceae) in Africa, C. minor is recorded from flowers of Cassia (Fabaceae), and C. antennalis is recorded from plants of the family Apocynaceae.
A new species of Curtara DeLong & Freytag (Insecta: Hemiptera: Cicadellidae) from Middle Western Brazil
Authors: COELHO LUCI BOA NOVA , DA-SILVA ELIDIOMAR RIBEIRO
Published: January 2020

The Neotropical genus Curtara DeLong & Freytag (Cicadellidae: Iassinae: Scarinae) includes more than 160 described species, with 40 of them recorded from Brazil (Coelho & Da-Silva 1996; 2002). DeLong & Triplehorn (1978) erected the subgenus Curtara (Labata) for C. basala DeLong & Triplehorn from Paraguay. Later, DeLong (1980) included in this subgenus C. xingua DeLong from Xingu, Mato Grosso State, Brazil.
The Effect of miR-155 on the Regulation of Hyperplasia of Middle Membrane of Blood Vessel in Rat Hypertension Model
Authors: Wang Xiaoying , Hao Yanke
Published: January 2020

Vascular smooth muscle cell (VSMC) abnormal proliferation is related to hypertension. P27 can arrest cell cycle and its downregulation is associated with hypertension. miR-155 plays a regulatory role in VSMC proliferation, while its relationship with hypertension is still unclear. Bioinformatics
analysis reveals a relationship between p27 mRNA and miR-155. The present study explores miR-155's role in p27 expression, VSMC proliferation and apoptosis, as well as in the pathogenesis of hypertension. Dual luciferase assay verified the relationship between miR-155 and p27. miR155, p27,
α-SMA, and Ki-67 expressions in the thoracic aorta media of rat hypertension model were detected. VSMCs were cultured in vitro and grouped into, anti-miR-NC, anti-miR-155, pIRES2-blank, pIRES2-p27, and anti-miR-155 + pIRES2-p27 groups followed by analysis of cell cycle
by flow cytometry and cell proliferation by EdU staining. Hypertension rats were randomly divided into antagomir-155 and antagomir-control. Caudal artery systolic and diastolic pressures were measured. miR-155 suppressed p27 expression. miR-155 and Ki-67 expressions were significantly enhanced,
while p27 and α-SMA levels were reduced in the tunica media from hypertension rats compared with control. Downregulation of miR-155 and/or upregulation of p27 obviously declined cell proliferation and arrested cell cycle in G1 phase. Antagomir-155 injection significantly decreased
systolic and diastolic pressures, elevated p27 and α-SMA expressions in media, and reduced the thickness of tunica media. miR-155 enhances VSMC proliferation via regulating p27. miR-155 enhancement was related to hypertension. miR-155 plays a therapeutic effect in hypertension.
MiRNA-4665-3p Regulates Expression of PLD5 in Thyroid Cancer Patients and Predicts Death
Authors: Han Yifan , Zhou Lei
Published: January 2020

Thyroid cancer has become an increasingly common malignant tumor around the world, and its incidence is increasing year by year. In this study, mRNA microarray data of thyroid cancer patients from four periods were collected from the TCGA database. We performed a series of bioinformatics
analyses on these mRNA expression profiles, including differential analysis, co-expression analysis, enrichment analysis, regulator prediction, and survival analysis. There were 13126, 10914, 13585, and 13241 differential genes in the four periods; 4822 differential genes were obtained by
union and deduplication (p < 0.01). Weighted gene co-expression network analysis indicated a total of 21 functional disorder modules. In each module, PLD5, CHD4, ADGRA3, ITGA3, etc. were the key genes. Enrichment analysis showed that the dysfunctional module genes were mainly related
to pre-replicative complex assembly, Cytokine–cytokine receptor interaction, and MAPK signaling pathway. We downloaded thyroid cancer-associated miRNA microarray data from the GEO database for differential analysis. Then, we crossed the predicted ncRNA with the differential miRNA to
obtain thyroid cancer-associated regulatory factors. Finally, we found that miRNA-4665-3p regulates the core gene PLD5, and six regulators such as miRNA-3140-3p and miRNA-324-3p regulate the core gene CHD4. Survival analysis showed that both up-regulation of PLD5 expression and down-regulation
of CHD4 expression accelerated patient death. According to the above analysis, we believe miRNA-4665-3p regulates the expression of PLD5 and affects the development of thyroid cancer. Its up-regulation promotes the death of patients.
Sodium Alginate Microspheres Tissue Metabolism and Correlation Between Interventional Treatment of Liver Cancer Using Alginate Microspheres and Prognosis of Liver Cancer
Authors: Huang Jinghua , Fu Yongan , Cai Zongda
Published: January 2020

To explore the effect of tissue metabolism of sodium alginate microspheres on liver cancer and the correlation between interventional treatment of liver cancer using alginate microspheres and prognosis of liver cancer in rabbits, in order to provide reliable data for human clinical
study. Rabbit liver cancer model was established through direct inoculation of liver cancer tissues. Rabbits in experimental group were treated with hepatic arterial embolization (HAE) as follows: sodium alginate microspheres was injected through femoral artery to three sites which was 0.5
cm (proximal), 2 cm (middle), and 3.5 cm (distal) far from the lesion, respectively to block the tumor's nutrient supply. Short-term clinical efficacy, 3 month survival rate, 6-month mortality rate, 1-year survival rate, and adverse reactions were measured. The complete remission rates of
proximal group, middle group, and distal group was 80%, 40%, and 20%, respectively. The complete remission rate of proximal group was significantly higher than that of middle group or distal group, with significantly higher complete remission rate of middle group compared with distal group
(P < 0.05). In terms of progress, a significant difference was seen between proximal group and distal group (P < 0.01). 3-month and 1-year survival rates were increased along with the decrease of distance from injection position to the lesion with the correlation equation
of y = –15.567x + 104.47 (R2 = 0.9429) and y = –13.333x + 91.133 (R2 = 0.9639). Six-month mortality rate was decreased along with the decrease of distance from injection position to the lesion with the correlation
equation of y = 15.343x – 5.9967 (R2 = 0.9943). The prognosis was correlated with the injection position of alginate microspheres. The closer the injection position to the lesion, the better prognosis.
Participation of Female Emerging Adults in a Theory- and Evidence-Based Behavioral Weight Loss Program
Authors: Johnson Ping H. , Annesi James J.
Published: January 2020

Emerging adults are less likely to participate in and more likely to drop out of behavioral weight loss programs. Thirty-five female emerging adults who dropped out of a behavioral weight loss program, Weight Loss For Life, completed an online survey. Main reasons for dropout relate to insufficient behavioral skills and unique characteristics of emerging adults, especially when in college (e.g., citing working and getting good grades to be more important than losing weight). Most desired >50% of program online, having virtual groups, and using small groups to model desirable behaviors. Around $140 and $180 seemed sufficient to them to encourage participation in all scheduled treatment sessions and reaching overall weight loss goal, respectively. Future behavioral weight loss programs for emerging adults may consider helping develop time management and task management, decision-making that focuses on longer term outcomes, and immediate tangible rewards similar to what college students typically receive after they complete each class assignment.
Complex Relationship Between Daily Partner Violence and Alcohol Use Among Violent Heterosexual Men
Authors: Katerndahl David , Burge Sandra K. , Ferrer Robert L. , Becho Johanna , Wood Robert
Published: January 2020

Although alcohol use and partner violence are consistently associated, the nature of the alcohol–violence relationship is still unclear. The purpose of this pilot study was to use longitudinal daily assessments of male partners’ alcohol use and violent events to identify the nature of the alcohol–violence relationship, employing both linear and nonlinear analyses. The participants were 20 adult heterosexual couples of whom the woman reported experiencing partner violence in the prior 30 days. Each partner provided a separate daily telephone report for 8 weeks via an automated interactive voice response (IVR), concerning the previous day’s violence, alcohol use, stressors, emotional reactions, and concerns for children. Individual IVR databases were merged to form a combined couple’s IVR time series. Time series were analyzed using graphic, linear, and nonlinear methods. Graphic analysis using state space grids found no consistent pattern across couples. Similarly, linear analysis using same-day cross-correlation and prior-day beta statistics found no significant group-level alcohol–violence relationship. Using cross-approximate entropy statistics and differential structural equation modeling, no nonlinear relationships between alcohol use and violence were noted either. Whether applying linear or nonlinear analytic methods, there is no group-level relationship between alcohol use by male perpetrators and their violent acts. The implications are significant. First, the alcohol–violence relationship may differ among subgroups. Second, couples need to be assessed thoroughly to determine their unique relationship with alcohol use, so that couple-specific interventions can be designed. Third, if perpetrators believe that their violence is facilitated by their alcohol use, then alcohol reduction should be encouraged despite any evidence suggesting a different alcohol–violence relationship. Finally, the accepted alcohol-causes-violence belief held by many providers needs to be reconsidered. Because the nature of the alcohol–violence relationship varies considerably across couples, clinicians should seek to understand their unique relationship applying across-the-board management approaches.
Fault-tolerant control with state and disturbance observers for vehicle active suspension systems
Authors: Kwon Baek-soon , Kang Daejun , Yi Kyongsu
Published: January 2020

This paper deals with the design of a fault-tolerant control scheme of active suspension systems for vehicle ride comfort. Unknown actuator failures from a variety of reasons cause performance deterioration of the active suspension controller. The proposed fault-tolerant control algorithm consists of two parts: a compensation for actuator failure and a fault mode selector. The main function of the fault compensation strategy is to estimate and compensate for the loss of effectiveness of the actuators. A suspension state observer and a disturbance observer operate simultaneously to determine the feedback control input. The controller and observer have been developed based on a reduced full-car dynamic model that contains only the vehicle body dynamics. The main advantage of the proposed observer is that an easily accessible and inexpensive measurement is only required and the effect of unknown road disturbance on the estimation error is completely removed. To cope with complete failure cases, the fault mode selector is also designed to redistribute the control input to the remaining healthy actuators. Tracking of the loss of effectiveness of the actuators is used for the fault model identification. The performance of the proposed approach has been evaluated via simulation studies. It is shown that the vehicle ride comfort in the presence of actuator faults can be improved by the proposed combined strategy of the fault compensation method and the fault mode selector.
Adjunctive therapy with brexpiprazole improves treatment resistant complex post traumatic stress disorder in domestic family violence victims
Authors: O’Connor Manjula
Published: January 2020

Objective:

Domestic family violence (FV) is a serious problem with serious impacts on mental health of victims. One such impact is post-traumatic stress disorder (PTSD), and it can be resistant to treatment (treatment-resistant or TR). This article offers novel treatment.

Methods:

Two treatment resistant case studies are described where adjunctive treatment with brexpiprazole was commenced. Possible theoretical considerations are presented to explain improvement.

Results:

Adjunctive treatment with brexpiprazole was associated with significant improvement in FV subjective and objective measures, with enhanced response to trauma therapy.

Conclusion:

Brexpiprazole improved complex post traumatic stress disorder in FV victims and needs further evaluation.
Labor Market Integration of Young Adult Refugees in Germany: Triangulating Perspectives Toward Program Development
Authors: James Sigrid , Seidel Franziska A. , Kilian Juri , Trostmann Julian
Published: January 2020

This article reports on the 18-month formative evaluation of a model project aimed at preparing young adult refugees (YARs) for entry into vocational education training (VET) as an essential step toward the labor market. Qualitative methods were used to gain insight into the perspectives of YARs, program staff, and vocational instructors as well as explore program dynamics. Within a longitudinal research design, 45 qualitative semistructured interviews were conducted with 22 of 27 program participants. Additionally, program staff and vocational instructors were interviewed. Qualitative content analysis guided the analytic process. Outcome data indicated that 83.3% of program completers or 55.6% of the program participants entered a VET within the evaluation period. Triangulated qualitative data revealed relevant program processes and generated hypotheses about factors that facilitate or hinder the difficult transition for YARs. Implications for program development as well as needed structural changes are discussed.
Efficacy of Rapid Maxillary Expansion Associated With Maxillary Protraction in Patients With Unilateral Complete Cleft Lip and Palate
Authors: Terumi Ozawa Okada , Daniela Salzedas Costa , Beatriz Oliveira de Lima , Sathler Renata , Baessa Gleisieli , Garib Daniela
Published: January 2020

Objective:

To evaluate the efficacy of rapid maxillary expansion (RME) and maxillary protraction (MP) in patients with unilateral complete cleft lip and palate (UCLP) using the Goslon yardstick index.

Design:

Retrospective study.

Patients:

Dental casts of 34 Goslon 3 (G3) and Goslon 4 (G4) patients treated with RME and MP were evaluated which composed the treated sample (S1). The dental cast were taken before the RME (T1) and immediately after the use of face mask for MP was suspended (T2). In order to verify the stability of the treatment, dental casts of 17 of these patients were evaluated 1 year after the treatment was finished (T3). For the control sample (S2), dental casts of 20 untreated G3 and G4 patients were evaluated.

Results:

At T2, 85.7% of study sample patients initially G3 and 70% of patients initially G4 obtained improvement in occlusal index. At T3, the majority of patients initially classified as G3 and G4 returned to the same classification as in the beginning of the treatment. The evaluation of the control sample showed that patients initially classified as G3, 55.6% continued at this initial index, and 44.4% had it worsened. Those initially G4, 100%, continued at this initial index.

Conclusion:

The immediate result of RME and MP was satisfactory, and despite the instability of these results, the outcome of this treatment option was better than the untreated sample.
Tele-ophthalmology for screening for eye diseases in older patients with cognitive complaints
Authors: Boureau Anne-Sophie , Masse Helene , Chapelet Guillaume , de Decker Laure , Chevalet Pascal , Pichierri Sophie , Weber Michel , Berrut Gilles
Published: January 2020

Introduction

Population-based studies show a significant increase in the prevalence of visual impairment in older patients. However, older patients and patients with lower Mini-Mental State Examination (MMSE) scores have few ophthalmological assessments. The main objective of our study was to evaluate the feasibility of tele-ophthalmological screening for ophthalmological diseases in older patients referred for cognitive assessment.

Methods

This monocentric prospective study included patients referred to a memory clinic for cognitive assessment. All patients underwent a geriatric assessment comprising a cognitive assessment associated with tele-ophthalmological screening undertaken by an orthoptist, including undilated retinal photography. The retinal photographs were subsequently sent to an ophthalmologist. We identified patients who were not eligible for ophthalmological assessment, for patients that had to come back due to poor-quality retinal photographs and finally for detected eye diseases. The association between the geriatric variable and newly detected eye diseases was analysed in univariable and multivariable analyses.

Results

The mean age of the 298 patients included was 83.5 years  ± 5.65; 29.5% were male. The mean MMSE score was 20.8 ± 5.2; 66.3% of patients had a diagnosis of dementia. Eighteen patients (6.0%) were not eligible for ophthalmological examination and 13 patients (4.6%) were asked to come back owing to poor-quality retinal photographs. Forty-one patients (13.7%) had a newly detected eye disease. In multivariable analysis, patients with a lower MMSE had significantly more newly identified eye diseases.

Discussion

The tele-ophthalmological screening method identified unknown ophthalmological diseases requiring specialised management in this older population with cognitive complaints.
A Hybrid Internal Iliac Artery Reconstruction for Open Common Iliac Artery Aneurysm Repair
Authors: Seligson Marc T. , Lim Sungho , Ambur Vishnu , Kirksey Lee
Published: January 2020

Common iliac artery (CIA) aneurysms present across a spectrum of anatomic variants that can pose unique operative challenges. A wide variety of procedural approaches have been described in the literature with current therapeutic options including both open and endovascular repair. These techniques may involve either ligation or embolization of the internal iliac artery (IIA) with reliance on collateralized blood flow to the pelvis to mitigate postoperative complications. However, preservation of the IIA is often preferred. This case report describes a hybrid surgical approach for treating CIA aneurysms while preserving IIA perfusion. Our technique mitigates the risks of hypogastric artery dissection (including hypogastric vein injury) in the presence of a large CIA aneurysm.
Hierarchical transformation-guided image registration for two-dimensional gel electrophoresis image
Authors: Wei Lifang , Dong Heng , Yang Changcai , Guan Zhe , Lin Wenfang , Miao Ying
Published: January 2020

Many proteomics studies have been devoted to investigate the gel-based methods for separation and fractionation of complex protein mixture extracted from tissues, cells, and other biological specimens. In order to fractionate, identify, and quantify proteins when coupled with mass spectrometric identification or other immunological tests, accurate image alignment method for possible significant protein diversity under different experimental conditions is of high demand. Although lots of protein spot matching and alignment methods have been proposed for two-dimensional gel electrophoresis image, very few methods work well because of dynamic appearance changes and structure changes for gel electrophoresis images. To address these difficulties, we propose a hierarchical transformation-guided registration method to not only align the global shape changes by affine transformation but also alleviate the local structure changes between two gel electrophoresis images by no-rigid deformation registration. The non-rigid registration method is used to obtain the local displacement with shape changes. Since such initial affine transformation can alleviate the global transformation difference between two images, it becomes efficient to use non-rigid registration to refine the registration result. The visualized and quantified experimental results show that our method is more accurate and robust to identify the variability between individual proteins.
Parental levels of stress managing a child diagnosed with type 1 diabetes in Riyadh: a cross sectional study
Authors: Aldubayee Mohammed , Mohamud Salaad , Almadani Khaled Ayman , Alabbad Abdullah Abdulrahman , Alotaibi Abdulaziz Ghazi , Alkhodair Abdulhakim Ali , Babiker Amir
Published: January 2020

Background

Caring for a child with Type 1 Diabetes (T1D) pose a significant burden on parents especially when they struggle with their child’s T1D management. The experience of not coping or struggling to cope increases the level of stress in parents, which may adversely affect their child’s diabetic control (Al Dubayee et al, Horm Res Paediatr 88:2019). In this study, we assessed the level of stress parents experience in caring for a child diagnosed with T1D in four different domains.

Methods

This was a cross-sectional study conducted in two specialized diabetic centers in Riyadh, Saudi Arabia, from February to May 2015 (Al Dubayee et al, Horm Res Paediatr 88:2019). We used an Arabic translation of the validated Pediatric Inventory for Parents (PIP) questionnaire. The frequency and perceived difficulty of stressful events were rated by interviewing parents caring for children with T1D using two 5-point Likert scales.

Results

The sample realized as 390 parents. The level of stress increased in separated and unemployed parents. The frequency (mean 64.9/210, SD 7.529) and difficulty (mean 65.3/210, SD 9.448) indices of the parental level of stress were compared with variables possibly associated with stress. Both of the frequency difficulty indices correlated with the marital status, the father’s level of education and occupation as well as HbA1c level (P-value < 0.05). In addition, the frequency index correlated with the frequency of hypoglycemia and the difficulty index correlated with the number of children in the family (P-value < 0.05).

Conclusion

Parents of children with T1D in Riyadh experience a significant level of stress that may affect the child’s glycemic control (Al Dubayee et al, Horm Res Paediatr 88:2019). Assessing the level of stress and providing support for these families has the potential to improve the clinical outcome.
Increasing the public health voice in global decision-making on nutrition labelling
Authors: Thow Anne Marie , Jones Alexandra , Huckel Schneider Carmen , Labonté Ronald
Published: January 2020

To respond to the global noncommunicable disease (NCD) crisis, the Codex Alimentarius Commission (Codex), a multilateral United Nations body responsible for work on food standards, is developing global guidance for front of pack (FoP) nutrition labelling. Guidance from Codex regarding FoP nutrition labelling at the global level will almost certainly influence national policy making. This shift in Codex’s activities towards standards to address NCDs presents new risks for achievement of public health goals, as a result of the high level of industry involvement in this forum; there is a potential commercial conflict of interest held by manufacturers of products whose consumption could be discouraged by such guidance. In this Commentary, we examine the implications of Codex processes for developing robust global guidance on FoP nutrition labelling and identify opportunities to increase consideration of public health objectives. To date, there has been significantly higher representation of food industry compared to public health actors in Codex discussions on FoP nutrition labelling. Without a strong public health voice in Codex, the industry voice could dominate discussions on FoP nutrition labelling, such that subsequent global guidance prioritises future trade and profits over potential risks to public health. There is currently a critical window of opportunity for public health interests to be prioritised in this multisectoral international forum. The key public health priority for global guidance on FoP nutrition labelling is to ensure protection of policy space for national governments to implement strong and effective regulation, and allow scope for innovation. Public health actors can engage directly with Codex processes, at both the national and global level, and also need to raise awareness among domestic policy makers – including with Ministries of Agriculture and Industry, which often represent countries at Codex – regarding the importance and effectiveness of FoP labelling in NCD prevention. Increased engagement with Codex processes represents a tangible new opportunity to strengthen global governance for public health, and move towards improved coherence between trade policy and health protection goals.
LncRNA LINC00662 promotes colon cancer tumor growth and metastasis by competitively binding with miR-340-5p to regulate CLDN8/IL22 co-expression and activating ERK signaling pathway
Authors: Cheng Bo , Rong Aimei , Zhou Quanbo , Li Wenlu
Published: January 2020

Background

LncRNA LINC00662 is closely related to the occurrence and development of cancer. This study aims to explore the effect of LINC00662 on colon cancer tumor growth and metastasis and its molecular mechanism.

Methods

CCK8, colony formation, transwell, scratch wound, TUNEL, flow cytometry, RT-PCR, western blotting and immunohistochemistry assays were used to detect the proliferation, apoptosis, invasion and migration of colon cancer cell and mRNA and protein expressions. Luciferase reporter and RNA pull down assays were used to detect the combination of LINC00662 and miR-340-5p or IL22 and the combination of miR-340-5p and CLDN8/IL22. Co-immunoprecipitation were used to detect the co-expression of CLDN8 and IL22 in colon cell lines. The targets of LINC00662 were predicated by Starbase v2.0. The target genes of miR-340-5p were predicated by miRDB and TargetScan. GO and KEGG enrichment analysis were performed by DAVID website.

Results

LINC00662 was up-regulation in colon cancer tissues and cell lines. Univariate Cox regression analysis showed that the LINC00662 expression level was related to the poor prognosis. LINC00662-WT and miR-340-5p mimics co-transfection depressed luciferase activity and IL22/CLDN8-WT and miR-340-5p inhibitors co-transfection memorably motivated luciferase activity. LINC00662 overexpression promoted cell proliferation, invasion and migration, and inhibited cell apoptosis in colon cancer. In vivo xenograft studies in nude mice manifested that LINC00662 overexpression prominently accelerate tumor growth. There was an opposite reaction in the biological functions of colon cells and tumor growth between LINC00662 overexpression and LINC00662 inhibition in vitro and in vivo. The functions of miR-340-5p mimics regulating the biological functions of colon cells and tumor growth were consistent with those of LINC00662 inhibition. CLDN8 and IL22, as target genes of miR-340-5p, reversed the functions of LINC00662 affecting the biological functions of colon cells and the protein levels of Bax, Bcl-2, XIAP, VEGF, MMP-2, E-cadherin and N-cadherin. Co-immunoprecipitation experiments indicated that CLDN8 directly interact with IL22 in colon cell lines. LINC00662 regulated CLDN8 and IL22 expressions and the activation of ERK signaling pathway via targeting miR-340-5p.

Conclusion

LINC00662 overexpression promoted the occurrence and development of colon cancer by competitively binding with miR-340-5p to regulate CLDN8/IL22 co-expression and activating ERK signaling pathway.
Type II acquired cutis laxa associated with recurrent urticarial vasculitis: brief report
Authors: Nabatanzi Amelia , Da Siqi , Male Musa , Chen Siyuan , Huang Changzheng
Published: January 2020

Background

Cutis laxa is a connective tissue disease characterized by loose, wrinkled, and redundant skin. It is either inherited or acquired. In most cases, acquired cutis laxa is associated with neoplasms, drugs, and autoimmune diseases. We present a rare case of acquired cutis laxa following a recurrent urticaria-like eruption in the absence of an autoimmune disease, neoplasm, drugs and or syndrome.

Case presentation

We report a case of a 45-year-old Chinese lady with a 1-year history of widespread pruritic urticarial eruption and a 6-month history of progressive skin wrinkling. On examination, the patient appeared older than her actual age, with apparent wrinkling on the mid-torso with generalized smooth, erythematous macules and wheals. A family history of similar conditions was absent. Biopsy revealed hypersensitivity and atrophy. Following the Food and Drug Administration (FDA) guidelines, we administered antihistamines, which relieved the itching, but her hyperpigmentation and cutis laxa never improved.

Conclusion

Our case shows that the decrease of elastic fibers may be associated with the infiltration of inflammatory cells in the dermis. This supports the hypothesis that chemical mediators may play a major role in the destruction of elastic fibers, thus causing cutis laxa. In addition, we advise practitioners to take a complete clinical and family history to determine if the condition is inherited or acquired.
CT and MR imaging of cystic renal lesions
Authors: Agnello Francesco , Albano Domenico , Micci Giuseppe , Di Buono Giuseppe , Agrusa Antonino , Salvaggio Giuseppe , Pardo Salvatore , Sparacia Gianvincenzo , Bartolotta Tommaso Vincenzo , Midiri Massimo , Lagalla Roberto , Galia Massimo
Published: January 2020

Cystic renal lesions are a common incidental finding on routinely imaging examinations. Although a benign simple cyst is usually easy to recognize, the same is not true for complex and multifocal cystic renal lesions, whose differential diagnosis includes both neoplastic and non-neoplastic conditions. In this review, we will show a series of cases in order to provide tips to identify benign cysts and differentiate them from malignant ones.
RETRACTED ARTICLE: Effect of hCMSCs and liraglutide combination in ALI through cAMP/PKAc/β-catenin signaling pathway
Authors: Feng Yun , Wang Linlin , Ma Xiaoying , Yang Xiaotong , Don Ocholi , Chen Xiaoyan , Qu Jieming , Song Yuanlin
Published: January 2020

Background

ALI/ARDS is the major cause of acute respiratory failure in critically ill patients. As human chorionic villi-derived MSCs (hCMSCs) could attenuate ALI in the airway injury model, and liraglutide, glucagon-like peptide 1 (GLP-1) agonist, possesses anti-inflammatory and proliferation promotion functions, we proposed to probe the potential combinatory effect of hCMSCs and liraglutide on ALI.

Methods

We examined the time- and dose-dependent manner of GLP-1R, SPC, Ang-1, and FGF-10 with LPS via western blot and qRT-PCR. Western blot and chromatin immunoprecipitation assay detected the effects of liraglutide on GLP-1R, SPC, Ang-1, and FGF-10 through PKAc/β-catenin pathway and cAMP pathway. In the ALI animal model, we detected the effects of MSC and liraglutide combination on ALI symptoms by H&E staining, western blot, ELISA assays, calculating wet-to-dry ratio of the lung tissue, and counting neutrophils, leukocytes, and macrophages in mouse bronchoalveolar lavage fluid (BALF).

Results

The data demonstrated that LPS reduced hCMSC proliferation and GLP-1R, SPC, Ang-1, and FGF-10 levels in a dose- and time-dependent manner. Liraglutide significantly dampened the reduction of GLP-1R, SPC, Ang-1, and FGF-10 and reversed the effect of LPS on hCMSCs, which could be regulated by GLP-1R and its downstream cAMP/PKAc/β-catenin-TCF4 signaling. Combination of hCMSCs with liraglutide showed more therapeutic efficacy than liraglutide alone in reducing LPS-induced ALI in the animal model.

Conclusions

These results reveal that the combination of hCMSCs and liraglutide might be an effective strategy for ALI treatment.
Dopamine D1 receptor-mediated activation of the ERK signaling pathway is involved in the osteogenic differentiation of bone mesenchymal stem cells
Authors: Wang Chen-Xi , Ge Xi-Yuan , Wang Ming-Yue , Ma Ting , Zhang Yu , Lin Ye
Published: January 2020

Background

Osteogenic differentiation of bone mesenchymal stem cells (BMSCs) is regulated by numerous signaling pathways. Dopamine (DA), a neurotransmitter, has previously been demonstrated to induce new bone formation by stimulating the receptors on BMSCs, but the essential mediators of DA-induced osteogenic signaling remain unclear.

Methods

In this work, we evaluated the influence of both dopamine D1 and D2 receptor activation on BMSC osteogenic differentiation. Gene and protein expression of osteogenic-related markers were tested. The direct binding of transcriptional factor, Runx2, to those markers was also investigated. Additionally, cellular differentiation-associated signaling pathways were evaluated.

Results

We showed that the expression level of the D1 receptor on BMSCs increased during osteogenic differentiation. A D1 receptor agonist, similar to DA, induced the osteogenic differentiation of BMSCs, and this phenomenon was effectively inhibited by a D1 receptor antagonist or by D1 receptor knockdown. Furthermore, the suppression of protein kinase A (PKA), an important kinase downstream of the D1 receptor, successfully inhibited DA-induced BMSC osteogenic differentiation and decreased the phosphorylation of ERK1/2. Compared with P38, MAPK, and JNK, DA mainly induced the phosphorylation of ERK1/2 and led to the upregulation of Runx2 transcriptional activity, thus facilitating BMSC osteogenic differentiation. On the other hand, an ERK1/2 inhibitor could reverse these effects.

Conclusions

Taken together, these results suggest that ERK signaling may play an essential role in coordinating the DA-induced osteogenic differentiation of BMSCs by D1 receptor activation.
Multiple homoclinic solutions for p-Laplacian Hamiltonian systems with concave–convex nonlinearities
Authors: Wan Lili
Published: January 2020

The multiplicity of homoclinic solutions is obtained for a class of thep-Laplacian Hamiltonian systems$\frac{d}{dt}(|\dot{u}(t)|^{p-2}\dot{u}(t))-a(t)|u(t)|^{p-2}u(t)+ \nabla W(t,u(t))=0$ddt(|u˙(t)|p−2u˙(t))−a(t)|u(t)|p−2u(t)+∇W(t,u(t))=0via variational methods, where$a(t)$a(t)is neither coercive nor bounded necessarily and$W(t,u)$W(t,u)is under new concave–convex conditions. Recent results in the literature are generalized even for$p=2$p=2.
Foundation News
Authors: Burk Katie
Published: January 2020

The SEG Foundation's Board of Directors welcomes two new members in 2020: Alex Biholar and Mark Leonard. In addition to these new members, Raymond Farrell and Michael Forrest were reappointed to the Board. The Foundation also expresses its deepest appreciation to Dave Monk, Glenn Bear, and Maurice Nessim for their resigned service but continued dedication to the Foundation and Society.
Pictorial review on the endovascular management of paediatric aortic injuries
Authors: Nicholas Neville W , Shaw David R , Puppala Sapna
Published: January 2020

Paediatric aortic trauma is a rare injury which can be fatal if not identified and managed appropriately. Surgical repair remains the gold-standard in moderate to severe aortic injuries. In the last decade however, endovascular treatment has gained popularity in children who have suitable vascular anatomy for intervention and are either not fit for surgery or in whom, endovascular intervention is the only alternative that will make a difference in the clinical outcome. Children pose a unique set of challenges to endovascular therapy. In this article, we aim to illustrate the different endovascular options that are available for the treatment of acute traumatic aortic injury and visceral thromboembolisation through pictorial representation. We will also demonstrate the feasibility and the limitation of this technique.
The “Omega sign”: a new radiological sign for a rare type of internal hernia involving the sigmoid mesocolon
Authors: Francis Kino Ceon , Daley Candice , Williams Bonnie-Paul Regis , Bullock Richard , Singh Ulanda , Baker Akil
Published: January 2020

The transmesosigmoid hernia is a rare type of sigmoid mesocolon hernia. Its presentation is non-specific and thus hardly ever preoperatively diagnosed. Its diagnosis often requires surgical corroboration. This case report aims to improve on the preoperative diagnosis with a proposed observed sign on CT. All literature reviewed described radiological findings related to the small bowel; thus, features of small bowel obstruction was the “hallmark” of internal hernias. This paper intends to describe the features of the sigmoid mesocolon internal hernias, illustrate and propose a never reported configuration of the sigmoid colon. This sigmoid colon configuration has a resemblance to the omega sign. We intend to present a new hallmark sign, which may serve as a clue in the identification of internal hernias involving the sigmoid mesocolon.