bluuebunny/crossref_metadata_2025 huggingface dataset:
DIGITAL MARKETING & BUSINESS OF E-COMMERCE ON PANDEMIC COVID19
Authors: Rizki Muhammad , Octaviani Dian
Published: April 2022

The aim of this paper is to examine the solutions adopted by MSMEs to survive and recover from the Covid19 pandemic crisis. The study's focus is on 37 thousand MSMEs that have been directly impacted by the pandemic. Literature was used as a method. According to this study, customers practically forget about a brand during a pandemic, but that brand awareness will be restored through digital advertising. The expansion of online customers is no longer being driven by the millennial generation. Some SMEs have gone out of business. But there aren't many who climb and then expand. MSMEs alter their manufacturing processes by lowering the amount of goods produced while also innovating to improve their competitiveness. On the other hand, digital marketing has been used extensively to raise client awareness. Marketplaces, as an e-commerce manifestation, are employed as a kind of innovation or change in sales tactics.
ANALYSIS OF THE EFFECT OF HDI, GRDP, AND MINIMUM WAGES ON POVERTY IN CENTRAL JAVA FOR THE PERIOD OF 2011-2020
Authors: Mahatma Avigna I Kadek , Musa Apriadi Ari , Princess Princess
Published: April 2022

This study aims to analyze the effect of the Gross Regional Domestic Product, Minimum Wage and Human Development Index partially or simultaneously on the poverty level in the Regency/City of Central Java Province (2011-2020). This study uses secondary data covering 35 districts or cities in Central Java Province based on cross section data and from 2011 to 2020 on time series data. The analytical method used is panel data regression analysis with Random Effect Model (REM) or Generalized Least Square (GLS). The results showed that simultaneously GRDP, UMK, HDI and Population had an effect on the level of poverty in Central Java Province. While partially (1) GRDP has a significant negative effect on the level of poverty in Central Java Province; (2) MSE has no effect on the poverty level in Central Java Province; (3) HDI has a significant negative effect on the poverty level in Central Java Province.
RICARDIAN EQUIVALENCE IN INDONESIA
Authors: Suhartoko YB , Pratikto Adji Pratikto , Kirana Indira
Published: April 2022

Expansionary Fiscal Policy in the form of Deficit Fiscal is still being debated due to differences in views regarding the effect of budget deficits. The Ricardian Equivalence disciple argues that Deficit Fiscal Policy has a neutral impact on consumption. In contrast, Non-Ricardians (Keynesian and Neoclassical) argue that Budget Deficit Policy affects Private Consumption. Government policies affect private consumption through deficit fiscal policies such as budget deficits, government spending, taxes, and government debt. This study analyzes the effect of the fiscal deficit on consumption and observes the existence of the Ricardian Equivalence View in Indonesia. The estimation model used is the Vector Error Correction Model (VECM) through IRF and VD testing with time series data from 1980-2018. The results showed that the Budget Deficit Policy had a significant positive effect on private consumption, where the Fiscal Deficit shock was responded positively by Private Consumption. So that the Ricardian view does not apply in Indonesia and is more inclined to the Keynesian view. The positive response continues in the long term permanently, where 58.42% of the variation in the formation of the Private Consumption indicator (in period 10), is a Budget Deficit.
Knowledge and attitudes towards the covid-19 vaccine
Authors: Aguilar Chávez Pablo V. , Becerra Julca Anita E. , Valverde Rondo Maria E. , Jesús Ramírez Gladis D. , Ñique Miranda Maria I.
Published: April 2022

Objective:The objective of this research was to determine the relationship between the level of knowledge and attitudes towards the COVID-19 vaccine in the inhabitants of the province of Trujillo in the year 2021. Materials and methods:The type of study was applied, non experimental desing, with a quantitative approach, cross-sectional, and correlational level; a questionnaire for knowledge and attitudes was administered to a total of 500 adults in the province of Trujillo. Results: The results show that 88% of the population has a good level of knowledge about the vaccine, and 91% of them have an adequate attitude to be vaccinated. Conclusions: In this way, it is concluded that there is a significant relationship between the level of knowledge and attitudes towards the vaccine against COVID-19 (p value<0.05). The level of knowledge is a protective factor (OR: 0.43; CI: 0.2318-0.8053) for an adequate attitude to be vaccinated.
Incidental Ectopic pancreas in gallbladder: a case report
Authors: Zamora Gonzales Pedro L. , Yagui Uku Carmen E. , Somocurcio Peralta José , Goicochea Ronald A.
Published: April 2022

Ectopic pancreas is an unusual finding, with an incidence below 0.5% of all reports worldwide. We report a 26 years old woman who went to emergency room with abdominal pain and underwent laparoscopic cholecystectomy. The pathology report described pancreatic ectopic tissue in the wall of the gallbladder. This finding must be thoroughly evaluated because this tissue can suffer diseases like pancreatitis, cystic tumours and malign degeneration, and should be considerated in the context of gallbladder polips with digestive sintomatology.
Peruvian experience on the human immunodeficiency virus diagnostic flowchart
Authors: Miranda Ulloa Eduardo F. , Romero Ruiz Soledad E. , Acuña Barrios Maribel , Briceño Espinoza Ronal , Obregon Boltan George , Suárez Agüero Dilan V.
Published: April 2022

Mr Editor: The Joint United Nations Program on HIV/AIDS (UNAIDS) proposed as a goal that the countries reach 95-95-95 by the year 2030, in other words, that 95% of people living with HIV (PLH) are diagnosed and of these that 95% receive antiretroviral treatment (ART) and at least 95% have undetectable viral load or viral suppression.
Preoperative magnetic resonance imaging in locoregional breast cancer
Authors: Aldecoa Bedoya Franklin , Placencia Medina Maritza
Published: April 2022

Introduction. The use of preoperative magnetic resonance imaging (PMR) in patients with breast cancer is debatable, with little agreement on its usefulness above routine scans. The goal of this study was to assess comparative studies of individuals with non-advanced breast cancer who were treated with or without PMR. Methods. A search was conducted in MEDLINE/PUBMED, LILACS, and SCIELO for medical literature published between January 1, 2000 and March 31, 2021, and publications that satisfied the inclusion criteria were included. Results. There were 3,828 publications, 53 of which matched the inclusion requirements; the papers were examined, and the findings were summarized in tables. There were 46 single or multicenter retrospective and comparative investigations, three prospective, randomized, controlled trials, and four meta-analyses including patients with infiltrating ductal or lobular carcinoma or ductal carcinoma in situ. The comparative results were antagonistic and debatable; however, in the most relevant studies, it was demonstrated that PMR delays surgery; increases mastectomies and additional biopsies; increases detection of ipsilateral/contralateral disease that is not necessarily malignant; and no significant difference in the rate of loco-regional or distant recurrence was established. Conclusion. Conclusions. PMR in non-advanced breast cancer has debatable outcomes in terms of surgery type, reoperations, and progression-free survival, and it is still being studied.
Factors associated with the non-compliance of the child vaccination of diphtheria, pertussis and tetanus in Peru, year 2019
Authors: Aquino-Sosa Bryan A. , Correa-Lopez Lucy , Loo-Valverde Maria , Guillén-Ponce Norka R.
Published: April 2022

Introduction:Pertussis tetanus and diphtheria, (DPT) are highly contagious diseases in children; worldwide vaccination schemes have been established for the prevention of these pathologies. However, different factors can lead to non-compliance with them. Objective: To determine the factors associated with non-compliance with the vaccination schedule against diphtheria,pertussis and tetanus(DPT) in Peru in2019. Methods:Analytical, retrospective study of secondary source based on data from 7 187 mothers between 15 and 49 years old regarding the vaccination schedule of their children older than six months of age obtained in the Demographic and Family Health Survey (ENDES) Peru 2019.The vaccination schedule of children over six months of age and the sociodemographic variables of the mothers were analyzed. A bivariate and multivariate analysis was performed using the chi square test for independence (p<0,050). Results:The sample included in the study was 7 187 mothers surveyed regarding the vaccination schedule for their children older than six months of age. The variables associated with the incomplete scheme by multivariate analysis were: low educational level (RPa: 1,19; 95% CI: 1,02-1,40), not having health insurance (RPa: 1,41; 95% CI: 1,23-1,60), wealth index poor (RPa:1,19; CI95%: 1,02-1,40), age of the mother under 20 years (PR:2,63; CI95%:2,06-3,35) and having two or more children (PRa:1,36; CI95%:1,19 -1,57). Conclusion: The index factors of wealth, mother's age, low educational level, not having health insurance and having more than two children are associated with non-compliance with the DPT vaccination schedule.
SENSITIVE PERSONAL DATA ON HEALTH AND LIMITS TO THE FLEXIBILIZATION OF THE RIGHT TO PRIVACY IN THE CONTEXT OF COVID-19 IN BRAZIL
Authors: Andrea Gianfranco Faggin Mastro , Gundim Wagner Wilson Deiró
Published: April 2022

A pandemia da COVID-19 expôs as profundas mazelas da desigualdade ao redor do mundo, mas também desnudou as inúmeras possibilidades de aplicação de novas tecnologias para o enfrentamento e controle da disseminação da doença. A tecnologia do Big Data atrelada ao monitoramento geográfico e o contact tracing exsurgem como reais possibilidades de controle da doença. Contudo, o problema que surge consiste na demasiada flexibilização do direito à privacidade e à proteção de dados pessoais sensíveis, que merece o estabelecimento de balizas que imponham limites a coleta e tratamento de dados sem desvios de finalidade. O artigo objetiva lançar luzes sobre a necessária ponderação entre o direito à privacidade e direito à saúde, com enfoque na proteção a ser garantida aos dados pessoais sensíveis. Para tanto foram utilizadas as metodologias de revisão bibliográfica, bem como do estado da arte de temáticas como vigilância e direito à privacidade. Por fim, concluiu-se que há a possibilidade de estabelecer limites à flexibilização do direito à privacidade e proteção de dados no Brasil mesmo diante de situações emergenciais, pautando-se por princípios como da necessidade, finalidade, razoabilidade e proporcionalidade. O Brasil demonstra um atraso na incorporação dessas novas tecnologias, o que se sugere para enfrentamentos futuros de novas pandemias.
GUETOS E PRISÕES: A “IDENTIDADE” QUE INCLUI E EXCLUI POBRES E NEGROS À MARGEM
Authors: Wermuth Maiquel Angelo Dezordi , De Castro André Giovane
Published: April 2022

Resumo O artigo aborda a configuração das identidades das classes economicamente hipossuficientes e de cor negra na sociedade contemporânea. O estudo, que se justifica pela necessidade de compreensão da constituição identitária dos grupos considerados ameaçadores à ordem social, problematiza a influência dos guetos e das prisões, notadamente formados por pobres e negros, na categorização das identidades de tais indivíduos e da exclusão societal. A investigação científica, assim, com base no método hipotético-dedutivo, na abordagem qualitativa e no procedimento bibliográfico, busca: a) analisar a configuração identitária dos pobres e negros com base no estigma de estranhos, inimigos, perigosos, outros e criminosos; b) refletir a conformação da identidade dos presos mediante o fenômeno da prisionização; e c) identificar os guetos e as prisões como retratação do paradigma do campo à luz da biopolítica e dos direitos humanos. Por fim, ao corroborar a hipótese emergente da discussão, constata-se que os guetos e as prisões se estabelecem como espaços retratados no paradigma do campo e influenciam, dada a condição econômica e a cor da pele de seus membros, na conformação identitária e excludente dos sujeitos devido à imposição de estigma por terceiros e/ou ao fenômeno da prisionização.
DIREITOS FUNDAMENTAIS COMO ABERTURA PARA O PASSADO: DIÁLOGOS ENTRE RONALD DWORKIN E A TEORIA PÓS-COLONIAL
Authors: Lustosa Queiroz Marcos Vinícius , Scotti Guilherme
Published: April 2022

O artigo busca realizar uma aproximação entre teoria constitucional e pensamento pós-colonial, objetivando uma hermenêutica jurídica responsável perante a permanência da violência colonial. Neste sentido, primeiramente os direitos fundamentais na modernidade são caracterizados, especialmente a partir da teoria de Ronald Dworkin, como porta de entrada da moral e, consequentemente, da história no âmbito do sistema jurídico. Seguindo a esteira do teórico estadunidense, trabalham-se as consequências dessa relação íntima entre moral e direito para a hermenêutica constitucional. Em um segundo momento, define-se o pós-colonial e quais contribuições ele pode oferecer para deslocar as narrativas hegemônicas sobre a modernidade. A partir desse movimento, pós-colonial e constitucionalismo são cotejados no sentido de fornecer elementos para uma imaginação moral expandida e mais democrática dos direitos fundamentais. Retomando o pensamento de Dworkin, conclui-se com considerações sobre que tipo de responsabilidade moral temos na escrita do romance jurídico quando o sofrimento injusto e as lutas silenciadas por liberdade e igualdade são alçados ao palco da história constitucional.
NÃO É NÃO – COMO CONTRACONDUTAS NA DIREÇÃO DO “CUIDADO DE SI”
Authors: Schwengber Maria Simone Vione , Pinheiro Naira Leticia Giongo Mendes Pinheiro
Published: April 2022

Este artigo analisa a campanha Não É Não e alguns de seus desdobramentos. Discutimos essa campanha como manifestação de resistência, de contracondutas (FOUCAULT, 2008) em relação as atitudes de assédio percebidas como atos de violência, que limitam as liberdades individuais e coletivas no que se refere aos corpos das mulheres nos espaços públicos. Propomos um percurso teórico-metodológico para análise inspirado na perspectiva foucaultiana. O corpus de análise é constituído por recortes de dizeres enunciativos e de imagens postadas em páginas das redes sociais digitais. Das análises, destacamos que Não É Não reivindica o direito das mulheres de terem seus corpos preservados do assédio e de violências, deslocando-se do lugar submisso que lhes foi (é) imposto. Assim, na campanha Não É Não mobiliza-se a escrita, que produz um deslocamento nos usos e instaurando uma singularidade em relação ao que já foi feito com e por meio dos corpos, e, aos modos de como já foi dito, indica transformações nas regras de enunciabilidades, inaugurando o lugar de fala (pública) desse grupo de mulheres. Entendemos essas ações como contracondutas, como disponibilidade numa relação ética de “cuidado de si”.
REGULATION OF JUDICIAL IMMUNITY IN CENTRAL EUROPEAN CONSTITUTIONS. A COMPARATIVE PERSPECTIVE OF POLISH EXPERIENCE.
Authors: Jakub Zurek
Published: April 2022

O principal objetivo deste artigo é a apresentação da regulamentação constitucional da imunidade judicial na Polónia. O autor descreve o art. 181 da constituição polaca e define o tipo de imunidade concedida aos juízes. O autor também analisa o alcance subjetivo e objetivo da imunidade e compara-o com regulamentos constitucionais semelhantes de outros países da Europa Central. Também inclui informações e comentários sobre as tensões políticas atuais entre o governo e os juízes, que são determinadas até certo ponto, pelas mesmas questões que são o assunto do artigo.
Desenvolvimento de sorvete antiemético com alto teor proteico para pacientes oncológicos em tratamento quimioterápico
Authors: Moreira Gabriele , Domingos Campos da Silva Luiza , Regina Zacarias Silva Andrea
Published: April 2022

Câncer é o nome dado a um conjunto de doenças caracterizadas pelo crescimento desordenado de células, que invadem tecidos e órgãos. As células dividem-se rapidamente, geralmente sendo agressivas e incontroláveis, podendo espalhar-se para outras regiões do corpo.  Estudos mostram que a maioria dos pacientes oncológicos em tratamento quimioterápico sofrem com efeitos colaterais, tais como mucosites, náuseas e êmeses (vômitos), tendo consequentemente uma má alimentação, levando à risco nutricional. Devido às complicações nutricionais que esses pacientes apresentam e dificuldade de se alimentar, consequências destes efeitos colaterais, este estudo teve como objetivo a elaboração de um sorvete antiemético e com alto teor proteico à base de Whey protein® e gengibre. O produto desenvolvido apresentou alto teor proteico, com 13.4g de proteína por porção, com possível propriedade antiemética por conter 1.2g de gengibre por porção e apresentou boa qualidade sensorial. Sendo assim, o produto desenvolvido pode ser utilizado como coadjuvante no tratamento de pacientes oncológicos em tratamento quimioterápico podendo auxiliar na melhora da ingestão alimentar e também na redução nos quadros de náuseas e êmeses.
Syphilis in pregnancy
Authors: Sadeep Melathil Sadanandan , Sobhanakumari Kunjumani
Published: April 2022

Congenital syphilis is showing a rising trend globally. Materno-fetal transmission of syphilis can be prevented by ensuring early diagnosis and prompt treatment of infected pregnant women. The risk of transmission from mother to child is directly related to the quantity of Treponema pallidum in the maternal circulation. Maximum number of the organisms is seen in early syphilis. Hence, early syphilis in mother (in comparison to late syphilis) places the baby at a higher risk for congenital syphilis. Amniocentesis and cordocentesis may help in the prenatal detection of congenital syphilis. Ultrasonography and Doppler studies supported by serological tests, and polymerase chain reaction, and dark field microscopic examination of the specimen from suspected lesions of early syphilis of mother may help to diagnose congenital syphilis prenatally. Benzathine penicillin G in appropriate dose is the ideal drug for syphilis in pregnancy, except for neurosyphilis for which the drug of choice remains crystalline penicillin.
Implementasi Fungsi Koordinasi Camat Dalam Pembuatan Kartu Keluarga Dan Kartu Tanda Penduduk Di Kecamatan Dumai Barat Kota Dumai
Authors: Rusli Rusli , Nurman Nurman
Published: April 2022

Salah satu tugas Camat dalam bidang pemerintahan adalah menyelenggarakan kegiatan pemerintahan yang berkaitan erat terhadap pelayanan masyarakat yaitu pembuatan Kartu Keluarga dan Kartu Tanda Penduduk, yang merupakan dokumen warga Negara yang wajib sebagai warga Negara yang baik dan benar. Permasalahan dalam pembuatan Kartu Keluarga dan Kartu Tanda Penduduk di Kecamatan Dumai Barat Kota Dumai yaitu seringnya terjadi keluhan masyarakat terhadap keterlambatan pembuatan KK dan KTP, selanjutnya tingginya biaya pembuatan KK dan KTP dan juga persyaratan KK dan KTP yang banyak belum ketahui oleh masyarakat, serta terjadinya kerusakan jaringan, matinya aliran listrik dan kerusakan perangkat komputer. Metode penelitian yang digunakan adalah metode Kualitatif dengan pendekatan diskriptif. Informan yang dijadikan objek kajian dari penelitian ini adalah Camat Dumai Barat, Kepala Badan Kependudukan dan Catatan Sipil Kota Dumai, Kabid Data dan Informasi Kependudukan pada Badukcapil Kota Dumai, Kasi Pemerintahan Kecamatan Dumai Barat, Petugas Operator KK dan KTP Kecamatan Dumai Barat dan masyarakat yang mengurus KK dan KTP di Kecamatan Dumai Barat. Teknik pengumpulan data dilakukan dengan cara pengumpulan literatur kepustakaan, melakukan observasi dan pengamatan langsung terhadap objek kajian serta melakukan wawancara secara face to face dengan informan penelitian yang didasari empat indicator penelitian yaitu komunikasi, sumber daya, disposisi dan Struktur Birokrasi. Dari hasil penelitian diketahui bahwa Implementasi Fungsi Koordinasi Camat Dalam Pembuatan Kartu Keluarga dan Kartu Tanda Penduduk Sistem di Kecamatan Dumai Barat Kota Dumai dari hasil penelitian dengan empat indikator diatas belum terlaksana dengan baik.
MPPT using Firefly Algorithm for Cuk Converter in Photovoltaic
Authors: Siswoko Siswoko , Safitri Hari Kurnia , Melfazen Oktriza
Published: April 2022

High intensity of sunlight in Indonesia (up to 10 hours per day) is a great opportunity to be utilized as renewable energy by absorbing solar energy using solar panels. The absorbed solar energy is channeled into a DC/DC converter circuit with a Cuk converter topology so that it can be used with small current ripples. The Maximum Power Point Tracker (MPPT) method is needed to get optimum power from solar panels. To optimize the MPPT value, its performance is supported by using the Firefly Algorithm (FFA). This study focused on observing changes in FFA parameters, i.e., firefly populations and random parameters to generate optimal power on Cuk converter topology with MPPT method. FFA embedded in microcontrollers has successfully optimized MPPT performance with the best response obtained in the firefly population = 25, absorption coefficient (γ) = 0.5, random value (α) = 0.6, iteration = 10, with an optimal power of 25.7 Watts.
Deep Learning for Channel Estimation and Signal Detection in OFDM-Based Communication Systems
Authors: Wong Kah Jing , Juwono Filbert , Reine Regina
Published: April 2022

The goal of 6G communication networks requires higher transmission speeds, tremendous data processing, and low-latency communication. Orthogonal frequency-division multiplexing (OFDM), which is widely utilized in 5G communication systems, may be a viable alternative for 6G. It significantly reduces inter symbol interference (ISI) in the frequency-selective fading environment. Channel estimation is critical in OFDM to optimize system performance. Deep learning has been employed as an appealing alternative for channel estimation and signal detection in OFDM-based communication systems due to its better potential for feature learning and representation. In this study, we examine the deep neural network (DNN) layers created from long-short term memory (LSTM) for detecting the signals by learning the received signal as well as channel information. We investigate the performance of the system under various conditions. The simulation results show that the signal bit error (SER) is equivalent to and better than that of the minimum mean squared error (MMSE) and least square (LS) methods.
Application of Genetic Algorithm for Economical Optimization of School Room Lighting According to SNI 03-6575-2001
Authors: Watini Uli , Kurnianto Rudi , Yusuf M Ismail , Purwoharjono Purwoharjono
Published: April 2022

The use of 24 and 30 FL for classrooms (9×8 m) and libraries (10×8 m), respectively, at SMP Negeri 25 Pontianak has not satisfied the lumen standard according to SNI 03-6575-2001. Replacing FL with LED requires calculation of budgets and lumen, including optimization of lamp distance configuration. Thus, replacing FL with LED through an adapted lumen of SNI 03-6575-2001 standard will need 15 and 20 lamps for classrooms and library, respectively. Later, the position of the LED placement has been optimized with the help of a genetic algorithm (GA) and drawing the lamp configuration using Dialux. Before optimization, the calculation result of luminaires for the classroom is 262 lux with a distance of x1 = 1.8 m and x2 = 2.67 m. After optimization, it is obtained that Eav = 283.513 lux and the distance between lamps x1 = 1.586 m and x2 = 2.67 m. The luminaire of library room before optimization is 322 lux, with a distance of x1 = 2 m and x2 = 2 m. After optimization the Eav is 384.9569 lux with x1 = 1.9119 m and x2 = 1.9 m. The lumen standard of replacing FL with LED has complied with SNI with cheaper procurement costs, i.e., for FL Rp.45,152,860.80 and for LED Rp.41,778,528.00 (saving Rp. 3,374,332.80).
PEREMPUAN SEBAGAI KOMODITAS WARUNG KOPI CETOL DI DESA GONDANGLEGI
Authors: 'arisi Roffa El , Wati Elya Kurnia , Meiji Nanda Harda Prama
Published: April 2022

The coffee shop is a second home for modern citizens amid the rise of coffee culture in male society. One way to attract customers with the existence by using women as waiters and even accompanying customers as in a small coffee shop. This study aims to find out: (1) how is the relationship between female waiters and customers in coffee shops, (2) the reasons why women are willing to work as waiters in cetol coffee shops, and (3) the views of the surrounding community on the existence of cetol coffee shops. The method used in this research is descriptive qualitative. The results obtained from this study indicate that the interaction pattern between the waiter and the cetol coffee shop customer uses symbols in providing services to customers, such as wearing tight clothes, sounding spoiled, and others. They work as servants because of economic factors, lack of job opportunities, and also want to fulfill their own needs independently, so these female servants do not care about the negative public response to their work.
POLA ASUH ORANG TUA KELAS MENENGAH DALAM MEMBANGUN PERILAKU SOSIAL ANAK USIA REMAJA
Authors: Apriani Reni , Widiansyah Subhan , Lindawati Yustika Irfani
Published: April 2022

The purpose  of  this study  is  to describe  and  analyze in-depth  about  parenting patterns  in  building social  behavior  of adolescents  in  Banjarsari  Subdistrict  Cipocok  Jaya  Serang  City.  The  research  conducted  is  qualitative  field  research,  where  this  research  produces  analytical  procedures  that  do  not  use  statistical  analysis  procedures  or  other  quantification  methods.The  method  used  in  this  study  is a descriptive  method.  Data  collection  techniques  are  conducted  among  others:  interviews,  observations  and  documentation.  Interviews  are  conducted  on  parents  and  children.  Observations  are  carried  out  to  see  the  parenting  patterns  given  to  the  child.  And  documentation  is  done  in  order  to  obtain  information  and  written  sources  or  documents  when  conducting  research.Parenting Patterns in Adolescent Social Behavior Development In Banjarsari Village, Cipocok Jaya District, Serang City, no parents are involved in raising their children, and only one parenting pattern is used in educating and caring for them.
Best Practice DFT Protocols for Basic Molecular Computational Chemistry
Authors: Bursch Markus , Mewes Jan-Michael , Hansen Andreas , Grimme Stefan
Published: April 2022

Nowadays, many chemical investigations can be supported theoretically by routine molecular structure calculations, conformer ensembles, reaction energies, barrier heights, and predicted spectroscopic properties. Such standard computational chemistry applications are most often conducted with density functional theory (DFT) and atom-centered atomic orbital basis sets implemented in many standard quantum chemistry software packages. This work aims to provide general guidance on the various technical and methodological aspects of DFT calculations for molecular systems, and how to achieve an optimal balance between accuracy, robustness, and computational efficiency through multi-level approaches. The main points discussed are the density functional, the atomic orbital basis sets, and the computational protocol to describe and predict experimental behavior properly. This is done in three main parts: Firstly, in the form of a step-by-step decision tree to guide the overall computational approach depending on the problem; secondly, using a recommendation matrix that addresses the most critical aspects regarding the functional and basis set depending on the computational task at hand (structure optimization, reaction energy calculations, etc.); and thirdly, by applying all steps to some representative examples to illustrate the recommended protocols and effect of methodological choices.
A new Simpson’s 1/3-type quadrature scheme with geometric mean derivative for the Riemann-Stieltjes integral
Authors: Memon Kashif , Shaikh M. M. , Malik K. , Chandio M. S. , Shaikh A. W.
Published: April 2022

The main purpose of this research is to develop and improve the Simpson’s 1/3-type quadrature scheme numerically utilizing the geometric mean derivative for the Riemann- Stieltjes integral. The proposed scheme of Simpson’s 1/3-type is described in basic form and also in composite form. The performance of the proposed scheme is compared with existing schemes by experimental results using MATLAB. It has been noted in numerical results that the performance of new proposed scheme is more efficient against the existing schemes in terms of errors, computational cost, and average CPU time.
The distributions of insect, wind and self pollination of plants in the Netherlands in relation to habitat types and 3D vegetation structure
Authors: Pan Kaixuan , Marshall Leon , Biesmeijer Koos , R. de Snoo Geert
Published: April 2022

Plants can be pollinated in many ways, with insect, wind and selfing as the most common modes. While it seems likely that the occurrence of pollination modes is correlated with environmental conditions, e.g. vegetation structure, and this remains uncertain. Here, we mapped the composition of pollination modes of different plant groups (woody species, herbs, and grasses) across (semi-)natural habitats and their distributions in relation to 3D vegetation structure in the Netherlands. We found insect pollination is the most common mode across (semi-)natural habitats for woody species and herbs. Woody species pollinated by insects showed an even higher percentage in dune, river swamp and swamp peat than in other habitat types, whereas herbs showed a higher percentage of insect pollination in dune than in other habitat types. Grasses were always pollinated by wind or wind-self in all habitats. Woody plants pollinated by wind showed a positive relationship with canopy densities in three different strata from 2 to 20 m vegetation, while insect pollination showed a positive relationship with the canopy density of 0.5 to 2 m vegetation. All grass presented negative relationships with canopy density. Herbs showed different relationships with canopy densities of different strata dependent on pollination modes. Insect-pollinated species increased with canopy densities of low strata but decreased with canopy density of high strata, whereas wind-pollinated species decreased with canopy density of both low and high strata. We conclude that habitat and vegetation structure are important factors driving the distribution of pollination modes.
GESTATIONAL DIABETES AS A POSSIBLE PREDICTOR OF LATE PREECLAMPSIA
Authors: I.V. Sakhautdinova
Published: April 2022

Abstract. Purpose of the study - We assessed the impact of gestational diabetes on the development of preeсlampsia.
Material and methods of research: We conducted a retrospective case-control study. Group I included 34 patients with preeclampsia, group II included 66 patients without preeclampsia. We analyzed the course of pregnancy and the development of gestational diabetes.
Research results. In the group of patients with late preeclampsia (after 34 weeks of pregnancy), we found a high incidence of gestational diabetes mellitus. The frequency of gestational diabetes was noted in 56% of cases, while in the group of healthy pregnant women, the incidence of this pathology is 4.55% as the average in the population.
Conclusions. Gestational diabetes mellitus can be considered one of the predictors of late preeclampsia. The course of diabetes is associated with progressive endothelial dysfunction, which can aggravate the existing compensated placental ischemia, which is one of the important pathogenetic links in the implementation of preeclampsia. We recommend explaining not only the risks of the underlying disease, but also careful self-monitoring of blood pressure at home in patients with diabetes. We also recommend testing for preeclampsia after detection of gestational diabetes mellitus (placental growth factor/fms-like soluble tyrosine kinase-1), which provides information on the likely debut of a hypertensive disorder within 4 weeks ahead.
CORRECTION OF DISORDERS ASSOCIATED WITH ESTROGEN DEFICIENCY IN POSTMENOPAUSAL WOMEN
Authors: O.B. Kalinkina , Yu.V. Tezikov , I.S. Lipatov
Published: April 2022

Abstract. We examined 76 women aged 59-69 years in the postmenopausal period with manifestations of menopausal syndrome. All women underwent a general clinical examination, including anamnesis collection and physical examination with weight measurement, gynecological examination, smear taking for oncocytology and blood pressure monitoring. In the group of women we examined, there were no indications for the appointment of an additional examination. Mammography, ultrasound of the pelvic organs, biochemical blood analysis (with determination of total protein, glucose, creatinine, bilirubin, AlT, AsT, alkaline phosphatase, calcium, phosphate content), coagulogram were performed, and serum concentrations of FSH, LH and estradiol were studied. The blood lipid spectrum and its parameters were studied: total cholesterol, triglycerins, β-lipoproteins). An ECG was performed. Bone mineral density was determined by two-energy X-ray densitometry. All these studies were performed primarily during therapy at 6 and 9 months and 1 year after therapy with tibolone. Various manifestations of postmenopausal menopausal menopausal syndrome were detected in all the examined patients and had different degrees of severity: endocrine-metabolic, urogenital, manifestations of osteoporosis were most pronounced in women who had passed more than ten years since menopause. The appointment of therapy with tibolone normalized the atherogenic potential of the blood, had a beneficial effect on the cardiovascular system, and stopped the manifestations of osteoporosis. There was a good tolerability of the drug, no side effects were registered.
Keywords. Menopausal syndrome, osteoporosis, menopausal hormone therapy, tibolone.
NEW DATA ON LIVING ANATOMY AND TOPOGRAPHY OF THE SPLEEN
Authors: I.Yu. Pikin , O.B. Nuzova , I.I. Kagan
Published: April 2022

Abstract. Currently, the study of various aspects of the clinical anatomy of the spleen is relevant. Currently available in the literature data on the anatomy and topography of the spleen, which, despite their great applied value, do not fully satisfy the needs of practical surgery. The introduction of computed tomography into clinical practice opens up new possibilities for intravital imaging of the spleen.
The aim of this study was to obtain new data on intravital anatomy and topography of the spleen using computed tomography.
Based on the analysis of 90 computed tomograms, the topography of the spleen of patients without pathology from the abdominal organs was studied. The shortest distance from the spleen to the stomach, aorta, midline of the body, pancreas, left kidney and colon at the level of the middle of the vertebral bodies in the axial projection, the levels of the gate and poles of the spleen relative to the vertebrae of the thoracic and lumbar spine, morphometric parameters of the spleen itself were determined. Statistica 10 software was used to process statistical data.
Conclusion. It was found that the most common skeletotopic variant of the spleen's location is one in which its upper pole is at the level of the XI projection of the thoracic vertebra, and the lower one is at the level of the II lumbar projection.
It is shown that in the axial projection, in most cases, the shortest distance from the spleen to the midline of the body, aorta, and stomach is at the level of the middle of the bodies of the XI and XII thoracic vertebrae. Thus, the method of quantitative assessment of the intravital topography of the spleen makes it possible to judge the variants of the anatomical variability of the organ under study in terms of not only its morphometric characteristics, but also the nature of the relationship to surrounding organs and structures. It was shown that the spleen in different people can be located quite variable relative to the bone structures, which are landmarks when performing therapeutic and diagnostic measures.
Keywords: intravital, anatomy, topography, spleen, computed tomography.
ANTITUMOR EFFECT IN VIVO OF THE NEW PYRIDINE COMPOUND
Authors: D.N. Shimanovsky , M.Y. Kudriavtzev , O.N. Deryabina , E.A. Samishina
Published: April 2022

Abstract. The study was the antitumor activity of a new compound - a pyridine derivative (LHT-13-19). On the culture of human colon cancer HCT116, the suppressive concentration of LHT-13-19 was determined during incubation of tumor cells in the concentration range from 10-9 to 10-7 M. The survival of tumor cells was also determined in the MTT test. Antitumor activity in vivo was studied on thirty athymic humanized 12-week-old female mice of the BALB / c nu / nu line with xenograft adenocarcinoma of the large intestine, divided into 3 groups, 10 mice each, which received intraperitoneal injections of 0.9% sodium chloride solution in a volume of 0.5 ml, cyclophosphamide at a dose of 10 mg / kg, LHT-13-19 at a daily dose of 3.7 mg / kg, respectively, for 10 days. Daily incubation of human colon tumor cells with LHT-13-19 is accompanied by the formation of the cytotoxic effect of the compound. In a xenograft model of colon adenocarcinoma, 10-day intraperitoneal administration of compound LHT-13-19 at a daily dose of 3.7 mg / kg was accompanied by the formation of an antitumor effect in the form of an increase in the doubling time of the tumor size, the survival rate of animals - carriers of xenograft, and a decrease in the frequency of metastasis.
Keywords. Pyridine derivatives, LHT-13-19, cell culture, anticancer activity, inhibitory concentration
LARON SYNDROME: DIFFERENT ASPECTS OF INSULIN-LIKE GROWTH FACTOR-1 DEFICIENCY
Authors: I.K. Fedyainova
Published: April 2022

Annotation: Laron syndrome (Laron-type dwarfism) is a rare endocrine genetic disorder with an autosomal recessive inheritance pattern caused by a variety of mutations in the growth hormone receptor. Typical manifestations include dwarfism, «doll» face and obesity. Currently, the number of patients in the world is about 350. It is noteworthy that these people almost never suffer from cancer, show a delayed age-related decline in cognitive abilities and some of them are quite resistant to type 2 diabetes. Moreover, animals with artificially induced «Laron syndrome» have a markedly increased lifespan. All these phenomena are explained by the fact that with this disease in the blood there is a very low level of insulin-like growth factor-1 — a compound that is normally secreted by cells in response to the effect of growth hormone and mediates its action in tissues. These observations suggest that the study of Laron syndrome may allow one to get closer to understanding the endocrine mechanisms of cancer and a number of other pathological processes, and, in addition, throw light on some of the molecular genetic foundations of aging and longevity. This article provides information on some of the already discovered interesting consequences of congenital deficiency of insulin-like growth factor-1, further study of which seems to be very promising.
"MURAVSKIY SHLYAKH" THROUGH THE PRISM OF SPACE AND TIME - TEXT ANALYSIS AS A RECEPTION OF LEARNING SENSE READING IN SECONDARY SCHOOL
Authors: Yu.A. Znamenskaya
Published: April 2022

Abstract. The article is devoted to the problems of developing semantic reading skills in literature lessons in secondary and high school. On the example of I. Bunin's story "Muravsky Shlyakh", a detailed literary analysis of the text is given on the basis of a conscious reading of the work. The author shows how understanding a specific word of a literary text leads to a correct interpretation of the author's position and the general meaning of the work. From a medical point of view, semantic reading creates new connections between brain cells. Analytical thinking in the process of reading allows you to turn on the cognitive functions of the brain, increase the concentration of thinking, thereby activating its work.
LUNG ALLOTANSPLANTATION: PAST, PRESENT, FUTURE
Authors: A.D. Kupryakova , Z.S. Kaitova , T.V. Lyapunova
Published: April 2022

Annotation: To date, lung transplantation is a recognized method of treating end-stage lung diseases in a number of patients with an exhausted medical treatment resource and opens a new direction in medical science - organ replacement therapy. We have analyzed the literature on methods of treatment of patients with orphan lung diseases. Lung transplantation is considered the main method of treatment. There are 3 methods of lung allotransplantation: unilateral, bilateral, or cardiopulmonary complex.
EXPRESSION OF P53 PROTEIN ASSOCIATES WITH ANTI-PD-L1 TREATMENT RESPONSE ON HUMAN-DERIVED XENOGRAFT MODEL OF GATA3/CR5/6-NEGATIVE RECURRENT NONMUSCULAR INVASIVE BLADDER UROTHELIAL CARCINOMA
Authors: G.V. Brykin , O.N. Deryabina , E.A. Samishina
Published: April 2022

Annotation: The study investigated the prognostic role of p53 expression in patients with GATA3 / CR5 / 6-negative recurrent nonmuscular invasive bladder cancer on the background of anti-PD-L1 treatment using a xenograft model in immunodeficient BALB / c nu / nu mice obtained from a patient. Twenty lines of patient-derived xenografts of relapsed high-PD-L1(+) double-negative NMIBC were developed, of which 10 lines represented high-grade tumors and the other ones—low-grade bladder cancer. Acceptors of each grade-related branch received specific anti-PD-L1 antibodies. Animals’ survival, tumor-doubling time, and remote metastasis were followed during the post-interventional period. PD-L1, GATA3, CR5/6, and p53 protein expressions in engrafted tumors were assessed by immunohistochemistry. The expression of p53 protein is an independent factor affecting the animals’ survival time of anti-PD-L1-treated mice with low-grade high-PD-L1(+) double-negative nonmuscular invasive bladder cancer. P53 expression may be considered as a prognostic factor for the anti-PD-L1 treatment efficacy of low-grade high-PD-L1-positive GATA3(-)/CR5/6(-)-relapsed noninvasive bladder cancer.
ANALYSIS OF NUTRITION`S EFFECTS ON PEOPL`S QUALITY OF LIFE IN THE ORYOL AND BRYANSK REGIONS
Authors: I.A. Filina , S.S. Nikishina , A.S. Kulakova
Published: April 2022

Annotation: Good nutrition helps maintain optimal health and reduce the risk of many diseases. The aim of the study was to analysis of nutrition`s effects on peopl`s quality of life in the Oryol and Bryansk regions. The works of domestic and foreign scientists in the field of food hygiene, as well as regulatory and organizational documentation were taken as an information base. The survey method served as the main research method. The objects of the study were the population aged 48 ± 30 years. As a result of the data obtained, it was revealed that 21.0% of respondents have chronic diseases of the gastrointestinal tract. It was found that 28.1% of the respondents do not have a diet. The majority of respondents abuse sweet, fatty, salty, smoked, and carbohydrate-rich foods, but they do not consume enough fish, vegetables, fruits, and fermented milk products. It was revealed that more than half of the respondents (56.1%) are overweight, of which 18.4% are obesity of the first degree; 5.3% - second degree; 3.5% - third degree. Thus, in the course of the study, it was found that the diet of the respondents, for the most part, does not correspond to energy consumption and the norms of physiological requirements for energy and nutrients for the adult population.
FEATURES OF THE USE OF OBSTETRIC ANAESTHETIC SUPPORT FOR PREGNANT WOMEN WITH COVID-19
Authors: M.A. Gulyaeva , A.V. Abramenko
Published: April 2022

Annotation: The available data on COVID-19 and pregnancy indicate that pregnancy and childbirth increase the likelihood of infection with the virus due to changes in the body, primarily in the respiratory and immune system organs. However, the association with the deterioration of the clinical picture in comparison with non-pregnant women of the same age group has not been proven. In this article (literature review), we analyzed data about how COVID-19 affects the course of pregnancy and examined the features of the application of anesthesia for patients undergoing cesarean section, based on international experience, due to the fact that pregnant women who develop pneumonia associated with COVID-19, have an increased risk of obstetric complications, premature birth, premature rupture of membranes, preeclampsia, cesarean section. Complications associated with a new coronavirus infection increase the need to receive anesthesia, which should be safe for the woman in labor, the fetus and medical personnel. Our knowledge of the epidemiology, pathogenesis, disease progression and clinical course of COVID-19 is constantly changing as more and more information becomes available. The research is based on articles on cases, case series, observational studies and randomized controlled trials describing women affected by coronavirus during pregnancy issued in 2019-2021. As a result of the study, it was concluded that in pregnant and maternity women with COVID-19, it is recommended to use conduction analgesia methods.
DIABETES MELLITUS TYPE 2 IN COMBINATION WITH ISCHEMIC HEART DISEASE: ROLE OF HNF1A GENE RS2464196
Authors: V.N. Maksimov , N.G. Lozhkina , A.A. Tolmacheva , V.V. Bezruchko , F.O. Muttakhirova , A.M. Ryzhikh
Published: April 2022

Annotation: Вackground. Diabetes mellitus increases the risk of heart and vascular disease and death. Early identification of susceptible individuals will allow more effective prevention of this disease.
Purpose of the study. To study the relationship of rs2464196 of the HNF1A gene by polymorphic variants with type 2 diabetes mellitus in combination with coronary heart disease.
Materials and methods. The study studied the frequencies of the rs2464196 genotypes of the HNF1A gene by polymorphic variants in patients with coronary heart disease and type 2 diabetes mellitus. Genotyping was performed using the Realtime PCR method (TaqMan probes, Applied Biosystems, USA) on an ABI 7900HT device in accordance with the manufacturer's protocol.
Results and conclusions. The study established the risk role of the AA rs2464196 genotype of the HNF1A gene in relation to diabetes mellitus in patients with coronary artery disease.
THE USE OF COMPLEX TRANSPLANTS ON A MOBILE NEUROVASCULAR PEDICLE FOR MANDIBULAR DEFECTS
Authors: P.V. Zakharova , Z.S. Kaitova , D.R. Asatryan
Published: April 2022

Annotation: The paper presents information about defects in the soft tissues of the face and lower jaw. Anatomical disorders of this pathology limit the functions of human viability. To date, methods for eliminating defects of the lower jaw are widely used.