bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of Topotecan and Folic Acid Effect in Jar Choriocarcinoma Cell Culture
Authors: EYÜP DOĞAN Rahşan , BARUT Aykut , SEL Görker , HARMA Müge , HARMA Mehmet , TEKİN İshak Özel
Published: April 2021

Aim: The purpose of this study is to search the effects and treatment efficacies of topotecan and folic

acid on the choriocarcinoma cultures generated in JAR cell culture.

Material and Methods: Human choriocarcinoma-like JAR cell is augmented in the 10% fetal bovis

serum and RPMI-1640 media, 95% air at 37°C with the existence of penicillin and streptomycin. Groups

to apply topotecan or folic acid are identified as below:Topotecan dissolved in dimethyl sulphoxide

(DMSO) and prepared as separate doses of 1, 5, 10 and 50 μg/ml. Substances are given to cells

simultaneously.

Results: In this study, the apoptotic effect of the use of topotecan only, in residual doses on JAR cell

series is statistically significant. The use of folic acid only, in residual doses has found to decrease the

apoptosis. In the combination of these two drugs in residual doses, the apoptotic effect of this drug is

even more increased, and statistically significant.

Conclusion: This is the first study which use the topotecan and folic acid separately and combined on

JAR, a human choriocarcinoma cell line model, and evaluation of β-hCG and h-hCG by the means of

immunoenzymatic method on the both two cell lines. Synergistic and apoptotic data gathered indicates

that topotecan and folic acid can be one of the treatment options in order to struggle multi-drug resistance

which is an enormous obstacle on treatment. However, the efficacy of drugs and effects of combination

therapies might be disparate in vivo; therefore data must be supported by animal experiments and after

that by clinical evaluations.
Ultrasonographic Characteristics of Thyroid Nodules in Predicting the Malignancy and the Role of the Cytopathologist
Authors: KILIÇ KAN Elif
Published: April 2021

Aim: It is very important to determine the correct nodules which should be evaluated with thyroid fineneedle aspiration biopsy (FNAB) and avoid unnecessary operations. In this study, we aimed to analyze the relationship and the compatibility between thyroid FNAB results with ultrasonographic features and the role of the pathologist who examines the specimens. Material and Methods: 458 patients with nodules who underwent FNAB were included in the study. The relationships between the ultrasonographic features (echogenicity, shape, margin, vascularization and calcification) and biopsy results and, the factor of the pathologist were evaluated retrospectively. Since there was no Bethesda VI (malignant) result, analyzes were made among 5 subgroups. FNAB procedures were considered as, inadequate or nondiagnostic, benign, atypia of undetermined significance (AUS) or follicular lesion of undetermined significance (FLUS), follicular neoplasia and suspicion of malignancy. Results: Solid internal structure, irregular margin, hypoechogenicity, presence of microcalcification, nodules with taller than wide (AP> T) were found significantly different between the subgroups of Bethesda classification system (p
Cerrahi Dumanın Ameliyathane Çalışanlarına Etkisi
Authors: AYDIN Nida , KAYA Ufuk , DAL YILMAZ Ümran
Published: April 2021

Amaç: Bu araştırma, ameliyathane çalışanlarının cerrahi duman konusunda görüşlerini belirlemek ve cerrahi dumanın etkilerine maruz kalan sağlık çalışanlarında meydana gelen belirtileri, bulguları ve aldıkları önlemleri saptamak amacıyla yapılmıştır. Gereç ve Yöntemler: Tanımlayıcı tipte olan araştırma Kasım 2019-Ocak 2020 tarihleri arasında gerçekleştirilmiştir. Araştırma KKTC’de bir üniversite hastanesindeki 67 ameliyathane çalışanı (doktor, hemşire, sağlık teknisyeni) ile tamamlanmıştır. Araştırma verileri, sosyodemografik özellikler ve cerrahi duman ile ilgili soruları içeren anket formu kullanılarak toplanmıştır. Verilerin analizinde tanımlayıcı istatistikler kullanılmıştır. Bulgular: Araştırma kapsamına alınan bireylerin %82,1’i cerrahi dumana maruz kaldığını düşünmektedir. Cerrahi dumana maruz kalan bireylerin; baş ağrısı (%47,8), bulantı (%35,8), öksürük ve boğazda yanma (%31,3), göz iritasyonu ve yaşarması (%29,9) ve solunum problemi (%22,4) yaşadıkları saptanmıştır. Çalışanların cerrahi dumandan korunmak için cerrahi maske (%77,6), aspirasyon kateteri (%55,2), önlük (%28,4) ve gözlük (%26,9) kullandığı ayrıca cerrahi duman hakkında eğitim almak istedikleri (%77,6) görülmüştür. Sonuç: Ameliyathanelerde cerrahi dumandan korunmaya yönelik alınan önlemlerin yetersiz olduğu ve çalışanların birçok semptom yaşadığı görülmüştür. Ameliyathanelerde cerrahi dumandan korunmaya yönelik önlemlerin alınması ve yazılı protokollerin oluşturulması önerilmektedir.
CONDUCTA ADICTIVA AL INTERNET: REDES SOCIALES, USO DEL TELÉFONO MÓVIL Y SU INCIDENCIA EN LA PERSONALIDAD.
Authors: Silva-Ortega Verónica , Zambrano-Villalba Carmen
Published: April 2021

El objetivo del presente estudio fue conocer los hábitos relacionados con posibles conductas adictivas al Internet, redes sociales y uso del teléfono móvil, que podrían presentar los jóvenes universitarios y la relación de dichos comportamientos con la personalidad. Para el presente estudio se utilizó un cuestionario de 10 preguntas para medir el grado de utilización y nivel de adicción al internet, las mismas que constan de cuatro opciones de respuesta, que van desde 1= raramente y 4= siempre. Para evaluar el comportamiento y personalidad se utilizó el inventario de personalidad Eysenck que consta de 57 ítems con respuestas de SI o No. De acuerdo a los resultados obtenidos, el 49 % de los encuestados fueron mujeres y el 51 % hombres, con un rango de edad entre los 22 y 25 años, que muestran diferencias estadísticamente significativas entre la puntuación media obtenida en los cuestionarios y variables como la edad y sexo. De manera general, se pudo observar que existió un bajo nivel de adicción al internet, como consecuencia no afectó significativamente en la personalidad de cada una de las personas participantes. En conclusión, los encuestados realizaron un uso moderado del celular e internet y otras redes sociales, determinado por conductas como navegar por Internet, siendo un grupo muy reducido de jóvenes los que sí se encuentran cercanos a tener un problema de adicción con tipo de comportamientos que afectan a la personalidad.

 

Abstract

The aim of the present study was to know the habits related to possible addictive behaviors to the Internet, social networks and the use of mobile phones, which could be presented by university students and the relation of such behaviors with personality. For the present study a questionnaire of 10 questions was used to measure the degree of use and level of addiction to the Internet, which consist of four response options, ranging from 1 = rarely and 4 = always. To evaluate the behavior and personality, the Eysenck personality inventory was used, which consists of 57 items with SI or No. answers. According to the results obtained, 49% of the respondents were women and 51% were men, with a range of age between 22 and 25 years, which show statistically significant differences between the average score obtained in the questionnaires and variables such as age and sex. In general, it was observed that there was a low level of Internet addiction, as a consequence it did not significantly affect the personality of each of the participants. In conclusion, the respondents made a moderate use of the cell phone and internet and other social networks, determined by behaviors such as surfing the Internet, being a very small group of young people who are close to having an addiction problem with type of behaviors that affect the personality.
REVISTA COMPLETA
Authors: Zambrano Villalba Msc. Carmen
Published: April 2021

REVISTA COMPLETA
TAMIZAJE PARA DEPRESIÓN POSTPARTO APLICADO A LA POBLACIÓN PUÉRPERA DEL PRIMER NIVEL DE ATENCIÓN EN SALUD.
Authors: Zhuzhingo-Vásquez Carlos , Peñaloza-Buele Yasmín , Ajila-Vacacela José , Aguirre-Carrión Carlos
Published: April 2021

La Depresión Postparto constituye un problema para la salud pública, cuya prevalencia real es aún desconocida. Puede aceptarse que 10 a 20% de las puérperas son afectadas por esta entidad clínica a nivel mundial. La escasa información científica que existe en nuestro país sobre este trastorno, permiten el subdiagnóstico o la confusión con otras patologías.  El objetivo del presente estudio es evidenciar la prevalencia real de este trastorno. Mediante la aplicación de escala de Edimburgo para DPP se realiza un estudio analítico, transversal y correlacional con los factores de riesgo para desarrollar la enfermedad. Se encontró una prevalencia del 27 % (50 casos), de un total de 182 puérperas que dieron positivo a la aplicación del test. Se crea la variable “madre soltera”, “adolescencia”, “alteración del estado del ánimo”, “patologías del recién nacido” que no requieren hospitalización, “analfabetismo”, “Violencia intrafamiliar” en las cuales no se obtiene significancia estadística. Las variables “Primigesta” (p=0,000), “Cesárea” (p=0,000), “Enfermedades del puerperio” (p=0,031), “Hospitalización de la puérpera” (p=0,031), “Hospitalización del RN” (p=0,000), ponen en evidencia el aumento del riesgo para DPP. Se concluye que la DPP una problemática muy frecuente que requiere mayor control mediante el uso de medidas óptimas para tamizaje diagnostico, tratamiento y seguimiento.
 
Abstract
Postpartum Depression is a problem for public health, whose real prevalence is still unknown. It can be accepted that 10 to 20 % of puerperal women are affected by this clinical entity worldwide. The scarce scientific information that exists in our country about this disorder, allows the underdiagnosis or confusion with other pathologies. The objective of the present study is to show the real prevalence of this disorder. Through the application of the Edinburgh scale for DPP an analytical, cross-sectional and correlational study is carried out with the risk factors to develop the disease. A prevalence of 27 % (50 cases) was found, out of a total of 182 puerperal women who tested positive for the test. The variable “single mother” is created, "adolescence", "Altered mood", "Pathologies of the newborn" that do not require hospitalization, "illiteracy", "family violence" in which no statistical significance is obtained. The variables "Primigesta" (p = 0.000), "Cesarean section" (p = 0.000), "Puerperium diseases" (p = 0.031), "Hospitalization of the Puerperium" (p = 0.031), "Hospitalization of the RN" (p = 0.000), they highlight the increased risk for PPD. It is concluded that PPD is a very frequent problem that requires greater control through the use of optimal measures for diagnostic screening, treatment and follow-up.
NORMAS DE PUBLICACIÓN
Authors: Zambrano Villalba Msc. Carmen
Published: April 2021

NORMAS DE PUBLICACIÓN
COEFICIENTE INTELECTUAL Y SU INCIDENCIA EN CONDUCTAS DISRUPTIVAS EN CASOS DE INFANTES DE 7-9 AÑOS DE EDAD.
Authors: Holguín Silva Angélica
Published: April 2021

Las conductas disruptivas a causa de un nivel de coeficiente bajo en relación con la edad del infante, es uno de los aspectos más atendidos en consulta, esta generalización conlleva a una serie de conflictos a la hora de adaptarse, compartir y desarrollarse en un contexto social. Los factores que se hacen presentes para observar estas situaciones críticas, son los psicosociales y familiares. La investigación se basó en el estudio y detección del coeficiente intelectual en relación a las conductas disruptivas. Los resultados permitieron evidenciar que el 80 % del nivel intelectual incide en las conductas disruptivas, haciéndose presentes también la relación de otros aspectos como el medio en el que se desenvuelve el infante, el área escolar, tipo de hogar, nivel económico, antecedente psicológicos-conductuales y familiares. Dentro de las conclusiones se puede afirmar que existieron varios factores adicionales que determinaron las conductas disruptivas de los sujetos de estudio.

Abstract

Disruptive behaviors due to a low level of coefficient in relation to the age of the infant, is one of the most attended aspects in consultation, this generalization leads to a series of conflicts when adapting, sharing and developing in a social context. The factors that are present to observe these critical situations are the psychosocial and family. The investigation was based on the study and detection of the intellectual coefficient in relation to disruptive behaviors. The results made it possible to show that 80% of the intellectual level affects disruptive behavior, and the relationship of other aspects such as the environment in which the infant develops, the school area, type of household, economic level, psychological background - behavioral and family. Within the conclusions it can be affirmed that there were several additional factors that determined the disruptive behaviors of the study subjects
MIEDO ESCÉNICO Y LA SUPERACIÓN PSICOLÓGICA EN ESTUDIANTES UNIVERSITARIOS.
Authors: Viejó Mora Israel , Quinto Saritama Enrique , Quinto Saritama Enrique
Published: April 2021

La investigación tiene como propósito determinar los factores que inciden en el miedo escénico en estudiantes universitarios y como afectan en sus procesos cognitivos, además de la superación psicológica al momento de exponer en público, así como indicar algunas técnicas para controlar este temor. El estudio fue realizado en la Universidad Estatal de Milagro para su efecto y ejecución, donde se aplicó el método cuali-cuantitativo, de tipo inductivo, aplicando entrevista y encuesta, para demostrar que los estudiantes no han tenido la oportunidad de conocer ciertas técnicas que le permitan superar el miedo escénico. Desde este contexto de investigación nace el estudio denominado: el miedo escénico y la superación psicológica en estudiantes universitarios.

Abstract

The purpose of the research is to determine the factors that affect stage fright in university students and how they affect their cognitive processes, in addition to psychological overcoming when exposed in public, as well as indicate some techniques to control this fear. The study was carried out in the State University of Milagro for its effect and execution, where the qualitative-quantitative method, of inductive type was applied, applying the interview and the survey, to demonstrate that the students have not had the opportunity to know certain techniques that allow him to overcome stage fright. From this research context comes the study called: stage fright and psychological overcoming in university students
Penerapan Algoritma EA-SHORT pada Protokol Routing AOMDV untuk Menemukan Rute yang Handal Berbasis Energi di Jaringan MANET
Authors: Hairani B. Nurwahyu , Hidayat Jatmika Andy , Bimantoro Fitri
Published: April 2021

Mobile Ad Hoc Network (MANET) is a stand-alone wireless network, consisting of several nodes that can move in all directions freely. The routing protocol used as the object of this study is Ad Hoc On-Demand Multipath Distance Vector (AOMDV). This research carries out an energy calculation process at a node that can be used as a new energy-based route by utilizing topology changes. Energy efficiency in the routing protocol can be done using the Energy-Aware SHORT (Self Healing and Optimizing Routing Techniques) method. The main purpose of the Energy-Aware SHORT (EA-SHORT) algorithm is to save energy on MANET, by extending the life of nodes and networks by routing packets through nodes that have enough remaining power and avoiding nodes that have low power. AOMDV performance will be compared with AOMDV which has been modified with EA-SHORT measured from the specified parameter values. Analysis results show that the application of the EA-SHORT algorithm in the efficiency of route search succeeded in improving performance. The results of throughput on EA-AOMDV increased by 13.904% for an area of ​​500x500 m2 and 13.905% at 1000x1000 m2. The packet delivery ratio increased by 0.91% and 2.273%. Average end-to-end delay decreased by 20.482% and 18.734%.
Dampak Variasi Model Propagasi Terhadap Protokol Routing Reaktif, Proaktif, dan Hybrid di Jaringan VANET (Studi Kasus Kota Bima)
Authors: Nazibullah Nazibullah , Jatmika Andy Hidayat , Bimantoro Fitri
Published: April 2021

VANET is a subset of Mobile Adhoc Network (MANET) that utilizes wireless technology, which in the VANET network the node is presented as a vehicle and the route for a vehicle is presented as a highway that will be passed by that vehicle. In general, VANET has 3 classification routing protocols, namely reactive, proactive, and hybrid. Performance of routing protocol is greatly influenced by the propagation model. Propagation on the network is the behavior of radio waves, which in this case is used as a transmission medium from the transmitter to the destination (receiver). This research will analyze the variation of propagation models namely FreeSpace,   TwoRayGround, Shadowing, and Nakagami on the performance of AOMDV (reactive), OLSR (proactive), and ZRP (hybrid). The performance of the routing protocol will be tested using test parameters including Packet Delivery Ratio (PDR), Packet Loss, End to End Delay, and Throughput.

Keywords: VANET, AOMDV, OLSR, ZRP, FreeSpace, TwoRayGround, Shadowing, Nakagami
Association of nephrolithiasis with the intake of carbonated drinks.
Authors: Adeel Maira , Zainab Saima , Athar Saima , Khoso Aneeta
Published: April 2021

Objective: To determine the association between the consumption of carbonated drinks and development of kidney stones. Study Design: Matched Case-control study. Setting: Liaquat National Hospital Karachi, Pakistan. Period: June 2017 to December 2017. Material & Methods: We recruited patients of nephrolithiasis admitted in Nephrology ward at Liaquat National Hospital as cases and controls from General Surgery ward. The sample size calculated was 186, with 93 cases and 93 controls, matched for age. Descriptive statistics of socio-demographic variables were computed. Multivariate logistic regression analysis was applied to determine the association between predictor and outcome variables. Results: A total of 186 patients participated in the study. Mean ages of the cases and controls were 34.92 (SD: 16.81) years and 31.76 (SD: 14.49) years, respectively. Around 66% of the cases and 75% of the controls had formal education. Approximately 16% of the cases and 10% of the controls were consuming soft drinks daily. Of them 77% were taking for more than 5 years. In multivariate analysis, we were unable to find significant associations between intake of carbonated drinks and kidney stones. However, the adjusted matched odds ratio (adj. mOR) for calcium intake was 6.36 (CI: 1.81- 22.33) and for caffeine intake was 7.9 (CI: 2.12 – 30.04). Those who had a past history of kidney diseases were at higher risk of developing kidney stones (mOR14.5; CI: 3.20- 65.76). Conclusion: The Study did not show any significant association of kidney stones with the intake of carbonated drinks. However, further longitudinal studies are required in order to confirm or refute any association between intake of carbonated drinks and nephrolithiasis.
Effect of learning approaches on the academic profile of fourth year undergraduate students of a Private Medical College.
Authors: Omar Naureen
Published: April 2021

Objective: To identify the learning approaches and assess the effect of learning approaches on the academic profile of fourth year MBBS students of a private medical college of Lahore. Study Design: Descriptive study. Setting: Fatima Memorial College of Medicine, Lahore, Pakistan. Period: July to September 2019. Material & Methods: 97 fourth year medical students. R-SPQ-2F validated questionnaire was used to identify the learning approaches. Academic profile in the form of percentages of university third professional examination were taken in two categories (<65% and >65 %) while academic background of intermediate and A levels examination was inquired after fulfilling all ethical considerations. Results: A total of 97 fourth year MBBS students participated having a mean age 22±0.889 with female predominance. Majority 89 (91.8%) had done intermediate compared to 8 (8.2%) A levels. Preferred learning approach was surface 52 (53.6%) compared to 45 (46.4%) deep. Strategic approach was dominant, surface strategy 32 (33%), deep strategy 26 (26.8%), surface motive 20 (20.6%) and deep motive 19(19.6%) respectively. Significant relationship (p 0.037) between learning approaches and academic profile was observed. Learning approaches were significantly related (p 0.002) with academic profile especially in students securing more than 65% having a deep strategy approach. Conclusion: Majority students were surface and strategic learners. Students with better academic performance were deep learners.
Ameliorative effect of Alpha-tocopherol on E-cigarette liquid induced histomorphological changes in adrenal cortex of male Albino rats.
Authors: Ahmed Ali , Lashari Mehreen , Bajwa Muhammad Imran , Lashari Jahanzaib , Bano Syeda Sara , Muhammad Dur
Published: April 2021

Objective: To study the ameliorative effect of Alpha-Tocopherol (Vitamin E) against E-cigarette induced histomorphalogical changes in adrenal cortex of male Albino rats. Study Design: Randomized Animal Control Trial. Setting: Department of Anatomy, Islamic International Medical College Rawalpindi in collaboration with National Institute of Health (NIH), Islamabad. Period: September 2018 to September 2019. Material & Methods: 30 adult male albino rats were divided in three groups having 10 rats each. Normal diet and distilled water was given to control group (Group I) including 10 rats, for 4 weeks. The Rats of Group II were injected E-cigarette liquid 0.5mg per kg body weight per day diluted in 500ul normal saline intraperitoneally for 4 weeks. The experimental rats in Group III, in addition to E-cigarette liquid also received Vitamin E, 100mg per kg body weight per day mixed in daily diet. Dissection of the animals was done after completion of 4 weeks and adrenal gland was removed for histological analysis. Data was recorded and analyzed in SPSS™ version 21. Results: Alpha-Tocopherol restored the quantitative changes induced by E-Cigarette liquid in adrenal cortex in Group III, which was increased in the rats of Group II who were injected E-Cigarette liquid. Among microscopic parameters Orientation of cells, sinusoidal dilatation was significantly reduced in all adrenal cortex zones by Alpha-Tocopherol in Group III animals. Conclusion: The current study demonstrated that Alpha-Tocopherol had an ameliorative effect on histological changes caused by E-cigarette liquid on adrenal cortex.
Association of body mass index with breakfast in medical student.
Authors: Abro Saleemullah , Saleem Qurratulain , Noor Ahad Ahmar , Khalid Ghulnaz , Khan Maham , - Fatima
Published: April 2021

Objective: To find out the association body mass index (BMI) with breakfast in medical student of Karachi. Study Design: Descriptive Cross-sectional study. Setting: Public Sector Medical Institutes of Karachi. Periods: 1st January to 31st March 2019. Material & Methods: 382 medical students were enrolled after taking informed consent. Data was collected from included students of this study, having age of 18 to 24 years and all medical students having history of lactose intolerance, anorexia nervosa, and food allergies were excluded from study. Data was collected by self made structured questionnaire and anthropometric measurements were collected. Body mass index was calculated as weight (Kg)/height (m)2. Collected data was analyzed by using Statistical package for social sciences version 22. Results: The mean age and mean Body mass index of studied samples were 20.83±1.54, and 15.53±3.5 respectively. Most of the participants were females and they belong to underweight category (BMI ≤ 18.5) of body mass index. The participants did breakfast were 81.4% and omit or skip breakfast was 18.6%. The habit of breakfast skippers was mostly in females (85.9%) and in males was 14.1%. The Body mass index (BMI) had as statistically significant (p<0.05) association with breakfast. Conclusion: The majority of medical students were females and habit of skipping breakfast most common in them, so body mass index were <18.5 kg/m2 in them and the Body mass index had as statistically significant (p<0.05) association with breakfast.
A prospective randomized study to see the effects of combined administration of dexmedetomidine plus propofol versus propofol alone in cardiac surgical patients.
Authors: Farooq Sajid , Rizvi Muhammad Farhan Ali , Hashmi Sana Urooj , Baig Mirza Ahmad Raza , Yousaf Hafiz Syed Muhammad Irfan , Munir Tasadduq
Published: April 2021

Objective: To compare the hemodynamics changes, intraoperative awareness and postoperative delirium after combined administration of dexmedetomidine plus propofol versus propofol alone in cardiac surgical patients. Study Design: Randomized Clinical Trial. Setting: Cardiac Center, Bahawal Victoria Hospital, Bahawalpur. Period: 1st December 2018 to January 2020. Material & Methods: Sixty-two (62) patients who underwent different cardiac surgical procedures were included in the study. Patients were randomly divided in group 1 {Dexmedetomidine (DEX) +Propofol} and group 2 {propofol alone}. Induction in group 1 was done by loading dose of DEX (0.7 microgram/kg) while induction in group 2 was done by Lignocaine 1.5 mg/kg. Heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and mean arterial pressure (MAP) were recorded at different time intervals. Intraoperative awareness and post-operative delirium was also assessed. Results: All hemodynamic parameters (HR, SAP, DAP, MAP) were statistically significant lower in group 1 in comparison to group 2 at different intervals indicating a more stable hemodynamic profile in group 1. End tidal CO2, pH, and peak airway pressures were not statistically significant between both groups. Intra-operative awareness was diagnosed in 1 (3.2%) patients in group 1 and in 5 (16.1%) patients in group 2 (p-value 0.08). Delirium was diagnosed in 3 (9.6%) patients in group 1 and in only 1 (3.2%) patients in group 2 (p-value 0.30). Conclusion: Combined administration of DEX and propofol produces more stable hemodynamics, less intraoperative awareness but more incidence of delirium as compared to propofol alone in cardiac surgical patients.
Frequency of cutaneous manifestations in drug abuse patients.
Authors: Rafiq Zahid , Mehdi Syed Muntazir , Shafi Urfa
Published: April 2021

Objective: Drug abuse and drug addiction cases have been increased immensely in last few decades in Pakistan. This study was conducted to assess the frequency of cutaneous manifestations in drug abuse patients. Study Design: Cross Sectional study. Settings: Dermatology Department of a DHQ Teaching Hospital/Sahiwal Medical College, Sahiwal and Central Jail Hospital, Sahiwal. Period: November 2019 to June 2020. Material & Methods: 50 patients with drug abuse irrespective of age and gender were selected. Skin manifestations based on history and examination recorded on predesigned proforma. Laboratory investigations and skin biopsies were performed to confirm diagnoses in doubtful cases. Results: A total of 50 male patients with age above 16 years were enrolled. Single drug addiction was noticed in 62% (n=31) and polydrug abuse was observed in 38% (n=19). Regarding mode of drug intake, single and multiple modes of drug administration were seen in equal number 50% (n=25) each. Major bulk of skin manifestations were chronic including skin scars 66% (n=33), xerosis 60% (n=30), hyperpigmentation 58% (n=29), oral mucosal changes 94% (n=47) and facial skin changes 60% (n=30). Acute along with chronic skin changes were observed in 30% (n=15) mainly including injection marks 30% (n=15), vascular changes 12% (n=6) and infections 8% (n=4). Conclusion: Skin scars, xerosis, hyperpigmentation and oral mucosal changes are the common skin changes observed among drug abusers. Thus, physicians need to be aware of skin signs of drug abuse for timely recognition of substance abuse disorders and effective management.
Potential pharmacological and non-pharmacological interventions for coronavirus disease 2019 (COVID-19): A Narrative Review.
Authors: Arif Taha Bin , Saquib Javeria , Iqbal Ayman , Ali Shajeea Arshad , Ahmed Farea
Published: April 2021

Coronavirus disease 2019 (COVID-19) originated in Wuhan, China, and subsequently spread to 215 countries and territories. Due to the high transmission rates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the disease has been declared as a pandemic by the World Health Organization (WHO). Scientists are striving to investigate and contribute new findings of the disease to the literature, especially related to the treatments and preventive measures that can be undertaken to curb its transmission. Multiple studies regarding medical interventions such as antivirals use, mesenchymal stem cell therapy, and convalescent plasma therapy have been published to date. Furthermore, non-pharmacological measures including the usage of personal protective equipment, undertaking proper hand hygiene, and social distancing has been reported to suppress the spread of this infection. However, a definite cure has not been discovered yet. In this review, we have summarized the effectiveness, potential risks, and side effects of all pharmacological agents and non-pharmacological preventive strategies as well as the prospects of possible vaccine for COVID-19.
Association of high BNP level with heart failure in patients presenting with STEMI.
Authors: Waqas Muhammad , Ilyas Hafiz Muhammad Faiq , Majeed Irfan , Ahmad Muhammad Nouman , Nazim Muhammad , Asghar Naeem
Published: April 2021

Objective: The objective of this study is to to determine the association of high BNP level with heart failure in patients presenting with STEMI. Study Design: Cohort Study. Setting: Department of Cardiology, Punjab Institute of Cardiology, Lahore. Period: 01 January 2017 to 30 June 2017. Material & Methods: After meeting the inclusion criteria 150 patients were enrolled. Informed consent and demographic information was taken. Then patients divided in two groups, high and normal BNP groups. Then patients were admitted in cardiology wards and were followed-up there for 5 days. Patients evaluated for symptoms of heart failure and underwent echocardiography for confirmation of presence or absence of heart failure. All the collected data was entered and analyzed on SPSS version 21. Results: In this study the mean age high BNP group was 48.87± 10.18 years while the mean age in normal BNP group was 48.99±12.15 years. Male to female ratio of the patients was 2:1. The heart failure occurred in 19(12.67%) patients. There is 1.58 times higher risk of heart failure in high BNP than normal BNP i.e. RR=1.58[1.14-2.19]. Conclusion: This present study concluded that high BNP level is strongly associated with heart failure in patients presenting with STEMI.
Frequency of distribution of joint involvement in rheumatoid arthritis patients.
Authors: Zafar Zafar Ali , Rehman Naveed Ur , Alam Muhammad Absar , Anwar Touseef , Sarfraz Muhammad , Saeed Hafiz Salman
Published: April 2021

Objectives: To determine the frequency of joint distribution in rheumatoid arthritis presenting at Independent University Hospital Faisalabad. Assessment of joint involvement in RA patients is not only important to determine the disease activity but also to assess the future joint damage. Study Design: Cross Sectional Study. Setting: Independent University Hospital Faisalabad. Period: July 2019 to Jan 2020. Material & Methods: 384 consecutive RA patients fulfilling inclusion and exclusion criteria, of either sex between age of 17- 60 years were enrolled from Rheumatology division of Independent University Hospital Faisalabad from July 2019 to Jan 2020. Frequency of joint distribution was assessed. Chi square test was used to compare the frequency of joint distribution among different treatment groups, age groups and gender, disease duration. A p-valve of < 0.05 was considered statistically significant. Results: In this study 384 patients with RA were studied. Joint distribution was determined according to pattern of joint involved at presentation. More patients (178) were noted in oligoarticular group, with predominant small joint involvement 111 (28.9%). 173 patients were noted in poly-articular group with 102 (26.6%) were in predominant small joint involvement. Conclusion: Pattern of joint distribution in RA patients is very important especially if there is monoarthritis or oligoarthritis, along with its association with gender, age of onset, disease duration, investigations.
Comparison of septoplasty with and without packing and splints.
Authors: Kumar Amrat , Kumar Ashok , Mehar Shabir , Kumar Dileep , Khan Muhammad Wasi Ullah
Published: April 2021

Objective: During septoplasty, nasal packing is routinely used by surgeons for hemostasis and balancing the cartilage and bony skeleton of the nose. However, these new techniques are not totally mild and therefore new ways are adopted to check their efficiency and reason their value. The study was performed to compare the use of plastic intranasal splints with or without anterior nasal packing to determine the need of nasal packing after septoplasty. Study Design: Comparative Study. Setting: ISRA University Hyderabad. Period: March 2018 to April 2019. Material & Methods: A total of 50 patients presenting with nasal septum in this period were prospectively examined. For the purpose of comparative study, we divided the patients into two groups: Group A –Patients who underwent septoplasty with packing and Group-B –Patients who underwent septoplasty without packing. We recorded the pain felt using Visual analogue scale before and after the surgery and also noted the Mean Age gender wise and recorded treatment results for statistical analysis using SPSS Version-20. Results: In our data, a total fifty (50) patients comprising 28 Males (68%) and 22 Females (32%) were listed in the study. The mean± standard deviation VAS scores of Group-A was at 5.2 ±0.9 and Group-B is 2.9±0.61 showing less pain in Group B-without splints and packing. However the complication rate in patients without Splints and packing was only 18%. Conclusion: Thus we find septoplasty without nasal splints and packing is more effective and cause lesser bleeding and pain to patients.
Re-designing Conventional Face Mask by Using Triz (Teoriya Resheniya Izobreatatelskikh Zadatch) Method
Authors: Padhil Ahmad , Ahmad Arfandi , Arman Muhammad , Ramadhan Saputra Ramlan Muhammad Dafha Reza , Indratma Rifdat , Lestari Nurul Dwiana
Published: April 2021

New Normal becomes the way out to keep Indonesia's weakened economy because of covid-19 pandemic stays in balance. Of course, New Normal must be well-balanced with the application of strict protocols to reduce transmission rates and anticipate a surge in new cases. From a few points of pandemic protocols, using face mask is considered as the most-effective basic need. Re-designing the mask is aiming at eliminating the worsening feature and developing the improving feature. This research is developing the widely used 1-ply mask, which doesn't meet WHO standard regarding cloth-material mask that must be made in 3-ply. The method used in this research is TRIZ (Teoriya Resheniya Izobreatatelskikh Zadatch), an inventive problem solving theory to the issues regarding ideas, products, or concepts, in this case is face mask redesigning concept. In this research, the data are collected by doing library research to obtain secondary data that will be processed in qualitative and quantitative methods. The results show the aspects that should be eliminated from cloth-material face mask are brittle for being easily damaged, short period of usage, and non-reusable. After the redesigning concept is carried out using the principles and features of TRIZ method, some aspects such as weight, material, design, and functionality are developed. The result is a relatively light weight face mask because the using of PLA+filament-based material with good durability and environmentally friendly. This design has a longer period of usage, and the user only needs to replace the additional inserted tissue every 4 hours. The researchers hope that the new design can be further developed by government to deal with New Normal and other possibilities in the future.
Pengaruh Senam Bugar Lansia Terhadap Tekanan Darah Pada Lansia Dengan Hipertensi Di Puskesmas Burneh Bangkalan
Authors: Sari Diah Jerita Eka , Mardiana Mardiana
Published: April 2021

Lanjut usia rentan mengalami perubahan,salah satunya pada sistem kardiovaskuler dengan penyakit yang sering terjadi berupa hipertensi. Salah satu faktor yang dapat mempengaruhi terjadinya hipertensi adalahkurangnya aktivitas fisik. Tujuan penelitian ini menganalisis pengaruh Senam Bugar Lansia terhadap tekanan darah pada lansia dengan hipertensi di Puskesmas Burneh Bangkalan.

                Desain penelitian pra eksperimental dengan metode one group pre-post test design. Populasi sebanyak 50 lansia hipertensi dan jumlah sampel sebanyak 45 lansia dengan teknik simple random sampling. Instrumen penelitian menggunakan lembar observasi dan pengukuran tekanan darah menggunakan sphygmomanometer dan stetoskop. Analisa data menggunakan uji Wilcoxon dengan SPSS 16.00.

             Sebelum melakukan senam bugar lansia sebagian besar mengalami hipertensi stadium 1 sebanyak 30 lansia (66,7%), dan setelah melakukan senam bugar lansia hampir seluruh lansia mengalami hipertensi stadium 1 sebanyak 37 lansia (82,2%), nilai uji statistik didapatkan hasil p = 0,002 α = 0,05 maka p<α dan H1 diterima. Ada pengaruh senam bugar lansia terhadap tekanan darah pada lansia dengan hipertensi di puskesmas burneh bangkalan.
Optimasi Penjadwalan Kegiatan Pondok Pesantren Dengan Precedence Diagram Method (PDM)
Authors: Yaqin M. Ainul , Fadhilah Farah Rizky , Rohmawati Linda , Umami Lisa Aulia
Published: April 2021

Islamic boarding school is a place for those who want to further explore the science of Islam. Not only a place to gain religious knowledge, Islamic boarding schools also have an education system that handles the scheduling system. The schedule is something that must be present in every activity in the Islamic boarding school. The activities at the Islamic boarding school are also quite numerous and crowded. In boarding schools, the problem faced is determining the schedule of Islamic boarding school activities so that the schedule of activities can be arranged optimally. In preparing the activity schedule, there are several things that must be considered, including the human resources involved, the facilities or facilities and infrastructure used, as well as the time taken during the activity. Of all Islamic boarding school activities in one year, it is necessary to have a calculation to find out how optimal the arrangement of the activity schedule is according to 52 boarding school standards. This study uses the Precedence Diagram Method (PDM) method by using a network diagram that can be used to complete the duration of the activities at the Islamic Boarding School conducted. The results of this study obtained an optimal schedule of activities with less time spent than the initial schedule arrangement that takes a total of 116 hours to carry out activities within one year. Using PDM project management can schedule Islamic boarding school activities so that activities can be completed on time.
Pengukuran Metrik Kompleksitas Model Proses Bisnis Sekolah
Authors: Yaqin Muhammad Ainul , Pratama Dicky Eka Asia , Rofi’uruttab Mohammad , Cahya Ilman Dwi
Published: April 2021

School as an institution that has a primary mission to educate and develop the character of the nation through a series of learning activities. School is an organization whose success goals are largely determined by the leadership style and organizational paradigm that is shared by all school components. Schools as organizations have business processes as a collection of procedures or activities that can define business objectives or objectives, generally in the context of organizational structures that can define functional roles and relationships within the organization. The main purpose of BPMN is to provide a notation that is easy to use and can be understood by everyone involved in business, which includes business analysts who model business processes, technical developers who build systems that carry out business, and various levels of management that must be able to read and understand processes diagram quickly so that it can help in decision making. To measure the complexity of a business process, complexity metrics are measured. This study uses the Cognitve Information Complexity Measure (CICM) method. Researchers took 3 SOPs of national education standards namely SOP curriculum development resulting in a standard value of complexity 425.1496, SOP for the Learning Process produced a standard value of complexity 2091.333 and SOP for Teacher Recruitment resulted in a standard value of complexity of 1145.49.
Otomasi dan Optimasi Pengaturan Kerja pada Pondok Pesantren Menggunakan Profile Matching
Authors: Ardhi Mokh Nugroho , Farazizah Annisa Dinar , Firza Fatmawati Hanifah , Yaqin Muhammad Ainul
Published: April 2021

Islamic boarding schools are religious institutions that provide education and teaching and develop and spread Islam. As an institution, Islamic boarding schools have many activities in them. In each activity requires an organizational structure to manage activities so that they are carried out properly. The process of selecting the person in charge is generally directly chosen by the board but this has both positive and negative sides. The positive side shortens the time in the election because there is no selection in determining the person responsible. The negative side of the direct appointment process is that it cannot see the abilities possessed by the candidates in charge of leadership, organization, and so on. This can only be known with the selection process, what often happens is the selection of the person in charge who does not have the appropriate ability. Under these circumstances, we need a system that can help boarding school administrators in facilitating the selection and appointment of the person in charge. In this study, profile matching is used to calculate the compatibility of the profile of the work and the profile of the person in charge. Each person in charge who is sought has each criterion consisting of core factors and secondary factors. The results obtained from this study are decision support systems that produce responsible recommendations in accordance with the criteria for each activity in the boarding school.
Prototype Smart Home Menggunakan Modul Wifi ESP8266 Dengan Aplikasi Telegram
Authors: Oktari Nisa Gracella Aslamia , Nurdin Ali , Rakhman Abdul
Published: April 2021

Smart Home is a technology that can make it easier for users to manage comfort and safety at home so they can control the equipment used, homeowners can open the gate automatically and check the temperature and humidity of the existing room at home. Sometimes homeowners forget to turn off or turn on the equipment used, and forget to close the gate again when no one is at home. From the above problems made a tool that can be used as a remote home appliance controller or can also be called smart home. This tool uses the ESP8266 wifi module as the main device and sensor control that is connected to the Telegram Application to give commands to the ESP8266 wifi module so that it can control the equipment used and is at home.
Penerapan Algoritma K-Means Dalam Mengelompokkan Rata-Rata Konsumsi Kalori Menurut Provinsi
Authors: Sinaga Juwitha Lovely Sweets , Solikhun S , Suhendro Dedi
Published: April 2021

Calories are a source of energy that we get from food intake that contains nutrients and as a basic human need for humans to survive. The number of people who consume excessive calories and do not pay attention to the amount of calorie intake that is consumed will result in the emergence of various diseases that are bad for health. In this case the government does not have information about the data on the average calorie consumption per province by province. The purpose of this study is to determine the highest and lowest clusters, for that the authors use Data Mining with the K-Means Algorithm to classify Average Calorie Consumption per day by province. This test is carried out using RapidMiner software. The results were obtained from the average grouping of calorie consumption grouped by two clusters: high and low clusters, high clusters of 13 provinces and low clusters of 21 provinces. Provinces that are classified as low clusters are expected to be a contribution for the Indonesian government for decision making in an effort to maintain a balanced consumption of calories per day and create a healthy lifestyle program in the future.
Analisis Penjualan Produk Paket Kuota Internet Dengan Metode K-Nearest Neighbor
Authors: Handoko Dedi , Tambunan Heru Satria , Hardinata Jaya Tata
Published: April 2021

PT. Akses Lintas Nusantara is a company engaged in the sale of Internet Quota Packages and package balances. This company has various data packages ranging from 6 GB, 11 GB, 21 GB and 32 GB with various price variations. Based on data on sales of internet quota package products for the past 1 (one) year, predictions for future sales are needed in order to facilitate the company in planning the provision of internet quota package stock. The K-Nearest Neighbor (KNN) algorithm is a method that is a supervised algorithm where the results of the new test sample are classified based on the majority of the categories on the KNN. To find out the sales of these products, the K-Nearest Neighbor algorithm is used. The expected result is to make it easier for companies to predict the future supply of internet quota packages in each region or region. The results of the research that have been carried out are prediction of Internet Quota Package Sales consisting of SP CL1, SPCL2, SPCL4 and SP CL8 with an Accuracy of 71.43%.
Analisis Metode Analytic Network Process pada Pemilihan Faktor Dominan Siswa Berprestasi di MTS Pembina
Authors: Warlinda Iis , Windarto Agus Perdana , Fauzan M
Published: April 2021

School is a place for students to gain knowledge. Every school has a goal which is to improve the quality of the education world, as well as the MTS Pembina Maligas Bayu school. To realize this goal there must be improvements in service, teaching and assessment in order to make a quality school. In this case the homeroom teacher is faced with a problem that is the selection of high achieving students who fit the criteria desired by the school. The purpose of this study is to analyze which factors are the most dominant in determining student achievement. The selection of high achieving students has many factors and has different values, so we need an Analytic Network Process (ANP) method to overcome them. Analytic Network Process (ANP) methods including decision support system techniques, Analytic Network Process (ANP) is a mathematical theory that allows dealing with interrelated factors and feedback in a structured manner. The data of this study came from student questionnaires which had a rating of 1-10. With alternative morals (A1), Grades (A2), Discipline (A3), Absence (A4), The role of the teacher (A5). Whereas A1 0.16%, A2 0.02%, A3 0.02%, A4 0.07% and A5 0.06%. It is hoped that this research can provide input to the MTS Pembina schools to focus on the dominant factor in the selection of outstanding students so as to increase the number of outstanding students.