bluuebunny/crossref_metadata_2025 huggingface dataset:
Review Paper Graphical Password Authentication Technique for Security
Authors: Rangari Mr. Shantanu , Ingole Prof. K. R.
Published: March 2022

Abstract: In modern age user authentication is a mandatory attribute in the area of data security. The characteristics of finding an individual generally based on a user id and password which is commonly used methodology for identifying users in system. Text based password is a general authentication method used from early times. There are numerous authentication systems like biometric, textual, graphical, smart card etc. Graphical password is an alternative to alphanumeric password which is tough to remember and generally forget by users as times passes. But in graphical password there is less probability to disremember password because people generally remember images more effortlessly than text based password. There are also fewer probabilities for intruder to take the graphical based password because hackers will not be capable to access the images uploaded by the user as password. Some graphical password schemes have been intended so far as it grows password usability and security. In this paper, we manner a wide survey of the current graphical password methods. Keywords: Graphical password, Text based password, usability, security, Attacks, Authentication
Diesel Engine Fuel Pump Pressure, Time Setting and Calibration
Authors: Shinde Mr. Bhushan Subhash , Pawar Dr. Usha C. , Kumar Mr. Rajesh
Published: March 2022

Abstract: For a diesel engine, fuel pressure time setting and calibration are very important parameters, which influence and increase the engine efficiency, performance, emissions, and combustion. Other injection parameters affecting engine performance are rate of injection, injection pattern, number of injections etc. A single cylinder research engine was used to experimentally determine the effects of fuel injection strategies and injection timings on engine combustion, performance and emission characteristics. The experiments were conducted at constant speed (2500 rpm) with two FIPs (500 and 1000 bars respectively) and different start of injection (SOI) timings. Cylinder pressure and rate of heat release (ROHR) were found to be higher for lower FIPs however advanced injection timings gave higher ROHR in early combustion stages. Brake thermal efficiency (BTE) increased with increased injection pressures while exhaust gas temperature and brake mean effective pressure (BMEP) increased up to 500 bars. These parameters reduced slightly with increase in fuel pressure time pump. Diesel engine combustion quality is based on the formation of fuel-air mixture. Enormous efforts have made to reduce the harmful diesel engine emissions. High engine noise, Particulate matter (PM) and NOx production are the results of improper combustion process and considered as the major constraints. The performance and emission characteristics of diesel engines depend on many parameters. Precise control over the fuel injection process is one of the most important factors and plays a very important role in combustion to increase the engine performance with minimal exhaust emission. The injection system must satisfy high pressure capability, injection pressure control, flexible timing control, and injection rate control. The purpose of this study is to find the performance and exhaust emission of diesel engines by implementing the combination of various high injection pressures and variable injection timings. Present paper is concentrated towords optimization of the best combination of high pressure injection with suitable injection timing in a diesel engine fueled with pure diesel, to reduce the emission and fuel consumption with increased engine power. Keywords: Diesel Engine fuel pump pressure, time,setting and calibration.
Big Data Analytics to Predict Breast Cancer
Authors: Patel Hardi , Barot Dr. Mehul P.
Published: March 2022

Abstract: Breast Cancer is the second cause of death among women. Early prediction of breast cancer will help with the survival of breast cancer patient. Machine Learning and Data Mining have been widely used in the prediction of breast cancer and on the early detection of breast cancer. This paper compares the machine learning techniques which are used for the prediction of breast cancer. Keywords: Breast Cancer, Malignant, Benign, Machine Learning, Big Data Analytics.
Apresentação
Authors: Santos Aline Benvegnú dos , Campos Carlos Eduardo da Costa , Birro Renan Marques
Published: March 2022

Apresentação
Borges e o arquivo infinito: tempo, memória e escrita da história na era digital
Authors: Kockel Marcelo Fidelis
Published: March 2022

Diante dos aspectos que as novas mídias digitais e o advento da internet podem oferecer à produção historiográfica, sobretudo no que diz respeito à sua arquitetura hipertextual de dimensão coletiva e aos seus impasses que tangenciam questões próprias às experiências temporais de memória, nosso objetivo será demarcar como esses dilemas já aparecem anteriormente na produção literária de Jorge Luis Borges. Assim, a partir dos conceitos de infinito e das categorias de tempo, memória e esquecimento, nossa proposta consistirá em mostrar como o escritor argentino pode fertilizar os debates historiográficos em tempos digitais.
“O que seria um corpo sem alma?”: Estado e Igreja no recrutamento de trabalhadores do Ceará para a Amazônia (1942-1945)
Authors: Semião Freitas Norma Sueli
Published: March 2022

A partir de 1942, em um contexto de guerra, a Igreja Católica e o Estado articularam-se na tarefa de arregimentar a partir da criação do SEMTA, “Soldados da Borracha”, “Soldados de Cristo” para a Batalha da Borracha. Logo, Vargas associa sua política demográfica denominada de “Marcha para Oeste”, orquestrando as migrações de interiorização do Brasil, notadamente, a de trabalhadores nordestinos para o Norte, de tal forma que representou um modo de asseverar a “redenção do sertão”; pois, se careciam possibilidades de trabalho, a alternativa estava em deslocar o excedente de mão de obra para a batalha da produção, aliando “planejamento, cientificismo e religião” no processo de recrutamento de força de trabalho para os seringais.
Pengaruh Model Pembelajaran Berbasis Masalah (PBM) Melalui Aplikasi Zoom Terhadap Berpikir Kritis dan Persepsi Siswa Dalam Pembelajaran IPA DI SMP Negeri 1 Ujan Mas
Authors: Sutrisno Tri , Irwandi Irwandi , Hasan Rusdi
Published: March 2022

The critical thinking ability of students in science learning is still low. This study aims to determine the effect of the problem-based learning model (PBM) through the zoom application on students' critical thinking in science learning at State Junior High Schools. The research method used in this research is Quasi Experiment. With pretest and posttest experimental group design. The population in this study were all seventh grade students of SMP Negeri 1 Ujan Mas in the 2020/2021 academic year with a sample of 2 classes, namely class VII.1 as a control class using conventional learning and class VII.2 as an experimental class using a problem-based learning model. , each class consists of 30 students. Collecting data using essay tests to measure students' critical thinking skills. The results showed that there was a significant effect from the application of the problem-based learning model through the zoom application on the critical thinking skills of SMP Negeri 1 Ujan Mas students and on students' perceptions that they were in the medium category.
Abstrak. Kemampuan berpikir kritis siswa dalam pembelajaran IPA masih rendah. Penelitian ini bettujuan untuk mengetahui pengaruh model pembelajaran berbasis masalah (PBM) melalui aplikasi zoom terhadap berpikir kritis siswa dalam pembelajaran IPA Di SMP Negeri. Metode penelitian yang dilakukan dalam penelitian ini adalah Quasi Experimen. Dengan desain pretes dan postest experimental group design. Populasi pada penelitian ini adalah seluruh siswa kelas VII SMP Negeri 1 Ujan Mas Tahun Pelajaran 2020/2021 dengan sampel sebanyak 2 kelas yaitu kelas VII.1 sebagai kelas kontrol yang menggunakan pembelajaran konvensional dan kelas VII.2 sebagai kelas eksperimen yang menggunakan model pembelajaran berbasis masalah, masing-masing kelas berjumlah 30 siswa. Pengumpulan data menggunakan tes essay untuk mengukur kemampuan berpikir kritis siswa. Hasil penelitian menunjukkan terdapat pengaruh yang signifikan dari penerapan model pembelajaran berbasis masalah melalui aplikasi zoom terhadap kemampuan berpikir kritis siswa SMP Negeri 1 Ujan Mas dan pada persepsi siswa masuk kedalam kategori sedang.
Pengembangan Lembar Kerja Peserta Didik (LKPD) Berbasis Inkuiri Terbimbing Pada Materi Fungi Kelas X SMA
Authors: Estitika Estitika , Haryanto Haryanto , Murni Pinta
Published: March 2022

This study aims to develop LKPD based on Guided Inquiry for Class X Fungi Materials in SMA. The development model used in this research is the Plomp development model which consists of three stages, namely; (1) initial investigation, (2) development and manufacture of prototypes, and (3) assessment. The LKPD was tested on tenth-grade students of SMA IT Diniyyah Al-Azhar Jambi City and biology subject teachers. The results of the design expert's assessment, it was found that the LKPD design was very feasible, with a score of 61 or 95.31%. Meanwhile, from the results of the material expert assessment, it was found that the material on the LKPD was very feasible, with a score of 110 or 86%. The results of individual trials, small group trials, and large-group trials, it was found that LKPD has a very practical level of practicality, with the acquisition of practicality scores of 34.67, 36.40 and 34.60, respectively. Likewise, the results of the practicality assessment by the teacher showed that the LKPD had a very practical level of practicality, with a practicality score of 35. It was concluded that the LKPD based on Guided Inquiry on Fungic Materials was very feasible and practical to use in learning activities.
Keywords: Development, LKPD, Guided Inquiry, Fungi Material
 
Abstrak. Penelitian ini bertujuan mengembangkan LKPD berbasis Inkuiri Terbimbing Materi Fungi Kelas X SMA. Model pengembangan yang digunakan dalam penelitian ini adalah model pengembangan Plomp yang terdiri dari tiga tahapan, yaitu; (1) investigasi awal, (2) pengembangan dan pembuatan prototype, dan (3) penilaian. LKPD diujicobakan kepada siswa kelas X SMA IT Diniyyah Al-Azhar Kota Jambi dan guru mata pelajaran biologi. Hasil penilaian ahli desain, didapatkan bahwa desain LKPD sudah sangat layak, dengan perolehan skor sebesar 61 atau 95,31%. Sementara dari hasil penilaian ahli materi, didapatkan bahwa materi pada LKPD sudah sangat layak, dengan perolehan skor sebesar 110 atau 86%. Hasil ujicoba perorangan, uji coba kelompok kecil, dan ujicoba kelompok besar, didapatkan bahwa LKPD memiliki tingkat kepraktisan sangat praktis, dengan perolehan skor praktikalitas masing-masing sebesar 34,67, 36,40 dan 34,60. Begitupula hasil penilaian praktikalitas oleh guru didapatkan bahwa LKPD memiliki tingkat kepraktisan sangat praktis, dengan perolehan skor praktikalitas sebesar 35. Disimpulkan bahwa LKPD berbasis Inkuiri Terbimbing Materi Fungi sudah sangat layak dan praktis untuk digunakan dalam kegiatan pembelajaran.
Kata kunci: Pengembangan, LKPD, Inkuiri Terbimbing, Materi Fungi
Faktor yang Berhubungan dengan Pemberian Imunisasi Dasar pada Bayi di Wilayah Kerja Puskesmas PAAL X Kota Jambi
Authors: Sari Puspita , Sayuti Solihin , Andri Andri
Published: March 2022

Imunisasi adalah suatu cara untuk meningkatkan kekebalan tubuh seseorang secara aktif terhadap suatu penyakit, sehingga bila kelak terpapar dengan penyakit tersebut tidak akan menderita penyakit tersebut. Tujuan Penelitian ini adalah untuk mengetahui hubungan pengetahuan, dukungan keluarga dan peran petugas kesehatan terhadap pemberian imunisasi dasar pada bayi di wilayah kerja Puskesmas Paal X Kota Jambi. Penelitian ini merupakan penelitian kuantitatif dengan desain penelitian adalah Cross Sectional. Pada penelitian ini yang menjadi sampel adalah Ibu yang mempunyai bayi umur 9-12 bulan, dengan jumlah sampel dalam penelitian ini berjumlah 79 orang. Hasil penelitian menunjukan dari 79 responden, 48 (60,8%) responden memiliki status imunisasi dasar tidak lengkap, 53 (67,1%) responden memiliki pengetahuan kurang baik, 49 (62,0%) responden memiliki dukungan keluarga kurang baik, 48 (60,8%) responden memiliki peran petugas kurang baik. Hasil analisis diperoleh hasil bahwa ada hubungan antara pengetahuan dengan nilai p value 0,009 (p < 0,05), dukungan keluarga dengan nilai p value 0,007 (p < 0,05) dan peran petugas dengan nilai p value 0,001 (p < 0,05) terhadap pemberian imunisasi dasar pada bayi di wilayah kerja Puskesmas Paal X Kota Jambi. Diharapkan kepada puskesmas meningkatkan penyuluhan kepada masyarakat sehingga masyarakat memahami akan pentingnya imunisasi dasar lengkap pada bayi selain itu agar petugas kesehatan memberikan informasi dan manfaat tentang pemberian imunisasi pada ibu yang memiliki bayi.
The role of immature platelet count and immature platelet fraction in determining the need for transfusion in patients undergoing CABG
Authors: yücel cihan , Ketenciler Serkan , Kayalar Nihan
Published: March 2022

Objective: Platelet dysfunction has been shown to play a role in
postoperative bleeding; however, it is not clear whether immature
platelets (IP) can induce appropriate homeostasis to prevent excessive
bleeding in patients undergoing CABG. This study investigated IP count
(IPC), IP fraction (IPF) and mean platelet volume (MPV) throughout the
hospitalization of patients undergoing CABG to elucidate their impact on
postoperative bleeding and need for transfusion. Methods: Fifty
consecutive patients undergoing elective CABG were included in this
prospective study. All CABGs were performed by the same surgical team in
a standardized fashion utilizing on-pump technique. IP and IPF were
measured preoperatively, after the completion of surgery and at
postoperative 1st,3rd, and 5th days. Whether need for transfusion was
associated with IP, IPF, MPV and platelet count was the primary outcome
measure of this study. Results: A significant increase in IPC and IPF
was observed at the postoperative first day compared to baseline values.
Preoperative IP and IPF were negatively correlated with intraoperative
blood transfusion (p=0.017, and p=0.049, respectively). Duration of the
operation, and preoperative hemoglobin and hematocrit levels were
significantly correlated with the length of hospital stay. However,
neither IP nor IPF were associated with the total amount of blood
components used throughout the hospitalization, and they were also
unassociated with the length of hospital stay. Conclusion: Although IPC
and IPF are weakly correlated with postoperative drainage and blood
transfusion frequency, they appear to have very little use –if any– in
the prediction of postoperative bleeding in patients undergoing CABG
Aberrant methylation of aging-related genes in asthma
Authors: Yang Yu , Yuan Lin , Yang Ming , Du Xizi , Qin Ling , Wang Leyuan , Zhou Kai , Wu Mengping , He Ruoxi , Feng Juntao , Xiang Yang , Qu Xiangping , Liu Huijun , Qin Xiaoqun , chi Liu
Published: March 2022

Background: Asthma is a complex pulmonary inflammatory disease which is
common among older adults.Aging-related alterations have also been found
in structural cells and immune cells of asthma patients. Of note, DNA
methylation have been proven to be play a critical mechanism for
age-related gene expression changes However, the methylation changes of
aging-related genes in asthma patients is still obscure. Methods: First,
changes in DNAm and gene expression were detected with multiple targeted
bisulfite enrichment sequencing and qPCR in peripheral blood of 51
healthy controls and 55 asthmatic patients. Secondly, the correlation
between the DNAm levels of specific altered CpG sites and the pulmonary
function indicators of asthma patients was evaluated. Lastly, ROC curve
and PCA were used to identify the feasibility of the candidate CpG sites
as biomarkers for asthma. Results: Compared with HCs, there was a
differential mRNA expression for 9 aging-related gene in peripheral
blood of asthma patients. Besides, the methylation level of the 9
aging-related genes were also altered, and a total of 68 CpG sites were
associated with the severity of asthma. Moreover, ROC curve and PCA
analysis showed that the candidate differential methylation sites can be
used as potential biomarkers for asthma. Conclusions: In summary, this
study confirmed the differentially expressed mRNA and aberrant DNAm
level of aging-related genes in asthma patients. The differential DMSs
are associated with the clinical evaluation indicators of asthma, which
indicate the involvement of aging-related genes in the pathogenesis of
asthma and provide some new possible biomarker for asthma.
R848 enhancement of the CD8+T cell response is dependent on DC-NK cell interactions
Authors: zhou jianchun , Tang hua , Shen Yuan , Zeng Menghua
Published: March 2022

Extensive in vivo and vitro studies showed that the Toll-like receptor
(TLR) 7/8 agonist resiquimod(R848) had potent Th1 adjuvant activity. The
role of R848 in Th1 induction is dependent on R848 induction of
dendritic cell (DC)maturation and the promotion of IL-12 production.
Here We demonstrated that R848 produced stronger Th1 induction than two
common TLR agonists and revealed that the stronger Th1 response induced
by R848 was attributed to DC-NK interaction. R848 induced IFN-γ+CD8+ T
cell and CD8+T cell accumulation in lymph nodes to a greater degree in
vivo than LPS(Lipopolysaccharide) and CPG-C(Class C CPG ODN).Increased
natural killer(NK) cell migration to lymph nodes occurred in
R848-immunized mice. R848 more potently activated DC and NK cells in
vitro. R848-activated DCs enhancedCD8+ T cell proliferation and
increased IFN-γ+CD8+ T cells with the assistance of NK cells. Further
study demonstrated that R848-activated DCs increased chemokine-CXCL9
production and induced more NK cell migration than DCs activated with
the other two TLR agonists. Taken together, our results show that R848
is a new potent Th1 immune adjuvant that may not merely depend on DC
activation, and NK cells must also be considered. With the growing
immunological understanding of the effects of R848, these findings
provide a new perspective for R848 application in clinical
investigations.
Patient satisfaction on drainless outpatient parotidectomy
Authors: Maniam Pavithran , Flach Susanne , Hey Shi Ying , Scott R. Adrian , Owusu-Ayim Mervyn , Manickavasagam Jaiganesh
Published: March 2022

Background: Parotidectomy is commonly performed as an inpatient
procedure due to drain insertion. However recent evidence suggests that
drainless outpatient parotidectomy is a safe option with comparable
postoperative complication and hospital readmission rates to inpatient
parotidectomies. Objective: Patient satisfaction on outpatient
parotidectomy is unclear and this study aims to report patients’
perspective and satisfaction on drainless outpatient parotidectomy.
Design, participants and outcome measures: Anonymous Core questionnaire
for the assessment of Patient Satisfaction’ (COPS) for general Day care
(COPS-D) questionnaire survey was completed by patients who underwent
drainless same day parotidectomy at Ninewells Hospital, Dundee from June
2018 to October 2020. Patient satisfaction on different aspects of their
outpatient parotidectomy journey (e.g. pre-admission, admission on ward,
in-theatre experience, nursing care, pain control and overall
satisfaction) were scored using a five-point Likert scale. Results: A
total of 31 drainless outpatient parotidectomies were performed and 28
patients completed the patient satisfaction survey. The majority of
patients were highly satisfied (i.e. scored 5/5) with their preadmission
visit (79.5%), admission on the ward (84.5%), operating room
experience (96.4%), nursing care (83.9%), medical care (87.5%),
information received (75.0%), autonomy (79.8%) and discharge and after
care (61.9%). Despite preferring drainless parotidectomy, 16/28
(57.1%) patients either stayed for less than 23 hours or preferred to
stay overnight in the hospital for non-surgical reasons. Conclusion:
Outpatient parotidectomy is well received by patients and the majority
preferred drainless parotidectomy over inpatient parotidectomy with
drains. Careful consideration should be given when selecting patients
for day case parotidectomy.
Ordered macro-mesoporous nanostructure of Pd/ZrO2 catalyst for boosting catalytic soot oxidation
Authors: Xiong Jing , Zhang Peng , Li Yuanfeng , Wei Yuechang , Zhang Yilin , Liu Jian , Zhao zhen
Published: March 2022

ABSTRACT: Herein, the hierarchical porous catalysts of three dimensional
ordered macro-mesoporous (3DOMM) ZrO2-supported active Pd nanoparticles
(NPs) were prepared by two-step methods of evaporation-induced
self-assembly-colloid crystal template (EISA-CCT) and gas
bubbling-assisted membrane reduction (GBMR). Ordered macroporous
structure can enhance diffusion and mass transfer of soot particles;
ordered mesoporous structure is beneficial to enhancing activation
ability for gaseous reactants. Synergistic effect of hierarchical porous
structure in the catalysts is important to improve catalytic activity
for soot oxidation. Pd/3DOMM-ZrO2 catalyst exhibits the highest activity
(T50=404 oC) for soot oxidation compared with the single macroporous or
mesoporous structure. The catalytic kinetics of hierarchical porous
Pd/3DOMM-ZrO2 catalyst for soot oxidation was systemically investigated,
i.e., its reaction rate is 0.038 μmolg-1s-1 at 310 oC, which is 2.7-fold
of power-type Pd/normal-ZrO2 catalyst (0.014 μmolg-1s-1). The
hierarchical porous structure is a good strategy to boost catalytic
activity during soot oxidation.
The whole spectrum of Hydroa vacciniforme-like lymphoproliferative disorder in a Chinese girl
Authors: Xie Yao , Wang Lin , Wang Ting
Published: March 2022

Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) is a rare
group of chronic EBV infection-associated diseases, and usually occurs
in childhood. The prognosis of HVLPD varies. Previous researches found
that the prognosis of adults with HVLPD is worse than children. Herein,
we report a case of HVLPD in an 8-year-old girl, but the clinical course
progressed rapidly, from the classic form of HVLPD to severe HVLPD, and
finally progressed into lymphoma. Fortunately, the patient was curable
by hematopoietic stem cell transplantation. To the best of our
knowledge, this is the most complete story of HVLPD in a same patient so
far.
On the characterizations of the curve couples according to Bishop frame in 3-dimensional Euclidean space
Authors: Atasoy Ali
Published: March 2022

The Bishop frame is considered as an alternative to the Frenet frame in
3-dimensional Euclidean space. This frame is usefull for the curves that
the second derivative is not available. In this study, for a curve in
3-dimensional Euclidean space, the conditions for the Bishop frame plane
to be the same as the Bishop frame plane of another curve are examined.
For this, nine possible cases are considered.
Molecular Basis of IGHG4-Related Low Serum IgG4 Subclasses in Down Syndrome
Authors: Jeraiby Mohammed
Published: March 2022

Background: Patients with Down syndrome (DS) are more likely to exhibit
immunological abnormalities that predispose them to infection. Among
other anomalies, individuals with DS have altered serum concentrations
of some subclasses of Immunoglobulin G (IgG), particularly the IgG4
subclasses The aim of the present study was to investigate the molecular
mechanism of low serum IgG4 at the level of the heavy chain gene
(IGHG4). Method: Quantitative real-time polymerase chain reaction (qPCR)
was carried out to measure the number of IGHG4 copies and to compare
those outcomes with a reference gene (36B4). An IGHG4/36B4 ratio was
considered normal (two copies of IGHG4) when between 0.8 and 1.2. We
studied 44 DS patients from 8 to 57 years of age, comprising 23 DS
persons carrying severe low serum IgG4 (< 0.02 g /L), with
five having an IgG4 level that was not detectable, and 21 DS patients
with normal serum IgG4 (level > 0.1 g /L). The patient
group was compared with 38 healthy donors (controls) without DS. Result:
IGHG4 heterozygous deletion was found in 16 (69.6%) DS patients with
low serum IgG4 versus in two (9.5%) DS with normal serum IgG4 (P
=0.0001). In the control group, deletion was found in 5.26% (2/38) of
the sample. Conclusion: IGHG4 haploinsufficiency is highly correlated
with low serum IgG4 in our population with DS, but other relevant
factors must to be assessed in future work.
Clinical Profile of Hospitalised Children with Pleural Effusion
Authors: Kumar Ashna , Razaq Mohd. , Malgotra Sugandhi , Sharma Preeti
Published: March 2022

Background: Pleural effusion is the pathological accumulation of fluid
in the pleural space. Pediatric pleural effusion usually present with a
dynamic profile over time both in terms of its etiology and the
causative organisms. This study aimed to provide a description of the
clinic-etiological profile of these patients with an emphasis to
identify the bacteriological spectrum of the pleural fluid for an
appropriate, and timely management of these children. Objectives: To
study the clinical profile of hospitalised children 0-19years with
pleural effusion. Materials and methods: A prospective hospital based
observational study was conducted on 133 children diagnosed with pleural
effusion to study its etiology and clinic-bacteriological profile in a
tertiary care hospital in north India. Results: The most common etiology
of pleural effusion observed in the study was tuberculosis (21.1%)
followed by empyema (20.3%). Maximum patients were in the age group of
6-12 years (36.8%) with males (54.1%) being affected more frequently
affected. Exudative effusion was more common than transudative effusion.
Fever and cough were the most common symptoms. Right sided effusion was
more common (49.6%).Parenchymal disease was associated in 22.6% of the
exudative effusion. The most common organism isolated was Staphylococcus
aureus followed by Streptococcus pneumonia. Significant association was
seen between age and the etiology of pleural effusion Conclusion:
Pleural effusion in children can have varied etiologies and proper
clinical history, examination and evaluation of the characteristics of
pleural fluid can help in identifying the etiology of pleural effusion
and selecting the best treatment approach for a favourable outcome.
Intuitionistic fuzzy ideals supra topological spaces
Authors: Abbas fadhil
Published: March 2022

In this paper, we present the idea of intuitionistic fuzzy ideals in
intuitionistic fuzzy supra topological spaces. Also present the
intuitionistic fuzzy S-local function in order to find a new
intuitionistic fuzzy supra topologies from original one. Moreover, we
introduce a Scompatible intuitionistic fuzzy ideal. Finally, we
introduce and study some type of sets in intuitionistic fuzzy ideal
supra topological spaces and introduce and study some of continuous
functions in intuitionistic fuzzy ideal supra topological space.
Analysis of endometriosis cases and its surgery techniques in our clinic
Authors: Kale Ahmet , uzun navdar , Basol Gulfem , Gundogdu Elif , Mat Emre , Yildiz Gazi , Kuru Betul , Uzun Fulya , Usta Taner
Published: March 2022

Aim: Endometriosis is a disease affecting women of fertile age, with an
estimated more than 176 million women worldwide suffering from their
symptoms, with no correlation between the degree and symptoms of the
disease. Although the initial treatment in endometriosis is medical
treatment, patients with severe symptoms are candidates for surgery as
the last choice. We contribute to the literature by publishing our 15
cases and to discuss surgical treatment methods. Method: Patients
operated due to the endometriozis in Kartal Dr Lutfı Kırdar Training and
Research Hospital between January, 2019 and January, 2020 were
evaluated. 15 patients were found according to the criteria. and
discussed according to the literature. All patients’ age, body mass
index, gravida, parity, medications, chronic diseases,, past surgical
history, duration of diagnosis time, ultrasonograph results, clinical
symptoms, physical examinations,surgical procedure, operation time,
complications, hospital discharge time, preoperative and postoperative
pain scores [10-cm visual analogue scale (VAS)] were analyzed
Results: When the postoperative VAS scores were evaluated, it was found
that the scores improved significantly compared to preoperative VAS
scores. Intraoperatively, ureter damage in one patient and bowel damage
in one patient were detected. Wound infection was detected as a
postoperative complication in one patient. Conclusion: Operations
performed by experienced teams in cases resistant to medical treatment
in endometriosis benefit the patient, as well as operations performed by
inexperienced hands may harm the patient. Therefore, we think that
patients who need endometriosis surgery should be directed to
experienced centers.
Phospho-proteomic analysis of the effect of merecidin inhibiting the human lung adenocarcinoma A549 cells
Authors: Jia Qinqin , Zhang Qiannan , Yang Tingting , Song Jinxuan , Wang Yarong , Wang Xiuqing
Published: March 2022

Merecidin induced A549 cells apoptosis. The present study aimed to
assess the differentially phosphorylated proteins in lung cancer A549
cells treated with antibacterial peptide merecidin. Methods: TMT/iTRAQ
labeling, LC-MS/MS analysis, HPLC grading, IMAC modification and
enrichment, and liquid chromatography-mass spectrometry of peptide. The
data of proteins were filtered according to the localization probability
>0.75 standard. The phosphorylated proteomics data were
analyzed using GO, KEGG, and STRING databases. Western blots examined
the changes in phosphorylated protein expression. Results: Protein
function enrichment showed significant changes in the phosphorylation
level with respect to protein binding, metabolic activity, molecular
function regulation, cell process, and biological function regulation.
Integrated pathway bioinformatics results showed that differential
proteins are associated with several pathways, including mTOR and AMPK
etc. Screening of the COG database revealed differentiated
phosphorylated proteins in cell signal transduction, RNA transcription,
translation processing and modification, ribosome synthesis of proteins,
cytoskeleton protein formation, intracellular material transport,
secretion, and vesicle transport. Protein interaction level analysis
identified an interaction network with HDAC1, RPL23A, SRSF3H, and
NCBP1.etc. The phosphorylated proteomics data and showed that after
merecidin treatment, ATG2B and ULK1s were significantly upregulated,
while MAPK1 and AKT were significantly downregulated. In addition,
Western blot also showed the upregulated level of ATG13,ULK1;MAPK1
downregulated. Conclusion: The results verified the feasibility of
phosphorylated proteomics analysis, confirmed the signaling pathways,
and suggested that merecidin may induce autophagy of lung adenocarcinoma
A549 cells.
Clinical features of children with mosquito allergy
Authors: Yavuz Suleyman Tolga , Akin Onur , Koc Ozan , Gungor Ali , Bolat Ahmet , Gulec Mustafa
Published: March 2022

Background: The aim of this study was to document the clinical features
of children with mosquito allergy and investigate the possible
associations between demographic features and type of reactions in this
population. Methods: Children with large local or unusual reactions
after mosquito bites who attended to our outpatient pediatric allergy
department were enrolled in the study along with control subjects.
Results: A total of 180 children (94 with mosquito allergy and 86 age
and sex-matched control subjects) with a median age of 6.8 years (IQR
5.5-9.3) were enrolled. Atopy (35.1% vs. 11.6%, p<0.001) and
grass pollen sensitization (28.7% vs. 8.1%, p<0.001) were
significantly more frequent in children with mosquito allergy. Skin
prick test with mosquito allergen was positive in only 6 children
(6,4%). Grass pollen sensitization was most common in children (28.7%)
followed by sensitization to house dust mite (9.6%). 30 children
(31.9%) had an accompanying atopic disease such as allergic rhinitis,
asthma or atopic dermatitis. Bullae were significantly more frequent in
children with asthma (41.7% vs.15.9, p=0.034). The median duration of
symptoms after onset were significantly longer in patients with
ecchymosis, with immediate wheals and in children whose symptoms start
in 20 min to 4 hours after mosquito bites. Conclusions: The role of
commercially available tests in the diagnosis of children with mosquito
allergy is limited. There is an association between unusual, large local
or exaggerated reactions after mosquito bites and allergic diseases in
children. The severity of reactions increases with age and particularly
in children with atopic background
Bidirectional nitrogen transfer, nodulation, and growth in an intercropping system of Eucalyptus and Dalbergia odorifera
Authors: Yao Xianyu , Goodale Uromi , Yang Mei , Liao Liangning , Yu Sufang , Wang Shengqiang , Ye Shaoming
Published: March 2022

We measured bidirectional N transfer and quantified the amount of
transferred N between Eucalyptus urophylla × grandis (Eucalyptus) and
Dalbergia odorifera (Dalbergia), to determine whether the facilitation
process from N transfer could improve Eucalyptus productivity and
nodulation of Dalbergia. A 15N leaf-labeling study was conducted by
using a pot experiment with Dalbergia and , and 15N was traced in the
labeled species as well as in neighboring trees at 90, 135 and 180 days
after labeling. Bidirectional N occurred between Eucalyptus and
Dalbergia, the amount of net transferred N was 21.8–127.0 mg plant-1 N
from Dalbergia to Eucalyptus, which was equal to 1.5–21.2 % of the
total N accumulated in Eucalyptus plants to increase the biomass of
Eucalyptus. The results also showed that the nodule number of Dalbergia
increased by 19.4–107.4 % in the intercropping system and further
improved its N2-fixation. The concentration of soil nitrogen, especially
the concentration of N-NH4+, was a major factor affecting N transfer in
this system. This study indicated that the advantage in Eucalyptus and
legume intercrops relates to ‘complementary N use’, which provide a
significant amount of N required for Eucalyptus productivity, and
maintain ecological sustainability.
Polymyositis in a child with thalassemia after hematopoietic stem cell transplantation: A case report
Authors: Tan Yonghong , Lin Jinzong , Hong Xiuli , Lu Jingyuan , Lu Quanyi
Published: March 2022

Polymyositis (PM) is a rare neuromuscular phenotype of chronic
graft-versus-host disease (cGVHD). Although glucocorticoids have been
shown to be effective for PM treatment, most people have poor treatment
response and poor prognosis. Herein, we reported a case of thalassemia
in a 6-year-old boy who received allogeneic hematopoietic stem cell
transplantation (HSCT) and consequently developed severe chronic GVHD
complicated with polymyositis. He was then given high-dose
corticosteroid therapy, including tacrolimus, ruxolitnib, and rituximab.
Twenty-three months after transplant, creatine kinase levels return to
normal range, the MRI showed that the original muscle edema signal was
significantly improved. In addition, the patient’s muscle weakness
continued to improve, and his overall condition was good. This report
suggests that glucocorticoids combined with immunosuppressants may be
effective agist polymyositis. Rituximab and ruxolitinib may be a good
choice in treating polymyositis.
880 nm NIR-triggered organic small molecular based nanoparticles for photothermal therapy of tumor
Authors: Zhao Yunying , He Zheng , Zhang Qiang , Wang Jing , Jia Wenying , Jin Long , Zhao Linlin , Lu Yan
Published: March 2022

Photothermal therapy (PTT) has received constant attention as efficient
cancer therapy method due to locally selective treatment and not
affected by tumor microenvironment. In this study, a novel 880 nm
near-infrared (NIR) laser triggered photothermal agent (PTA),
3TT-IC-4Cl, was used for PTT of tumor in deep tissue. Folic acid (FA)
conjugated amphiphilic block copolymer (folic acid-polyethylene
gly-col-poly (β-benzyl-L-aspartate)10, FA-PEG-PBLA10) was employed to
encapsulate 3TT-IC-4Cl by nano-precipitation to form stable
nanoparticles (TNPs), TNPs exhibit excellent photothermal stability and
photothermal conversion efficiency. Furthermore, the in vitro results
showed TNPs display excel-lent biocompatibility and significant
phototoxicity. These results suggest that 880 nm triggered TNPs has
great potential as an effective PTAs for photothermal therapy of tumor
in deep tissue.
Acoustic trauma inducing ‘low frequency’ sensorineural hearing loss; A cross-sectional study among medical students using Pure Tone Audiometry
Authors: Asghar Saba , Khan Hurtamina , Parveen Saima , Rafi Tariq
Published: March 2022

Objectives: This study aimed to ascertain current practices prevalent
among medical students using electroacoustic devices. We also aimed to
determine pattern and frequency of hearing loss among medical students.
Design: Cross-sectional Participants: Students of 3rd year and 4th year
MBBS at Jinnah Sindh Medical University, Karachi, Pakistan were
included. Data collection dated from December 2019 till February 2020
using convenience sampling technique. Setting: Students were invited to
ENT OPD, Jinnah Postgraduate Medical Centre, Karachi. Through a
structured proforma, we recorded practices regarding electroacoustic
devices. We investigated hearing of medical students by tuning fork
tests and Pure Tone Audiometry. Main Outcome Measures: Using SPSS
software version 23 we applied Chi square test, Pearson correlation and
independent t test at 95% CI and p=<0.05 as significance
level. Results: A total of 221 students fulfilled inclusion criteria.
96.4%(n=213) regularly used electroacoustic devices. Students mostly
used insert type earphones connected with a smartphone. More than 30%
of medical students demonstrated low frequency (0.25-0.5kHz)
sensorineural hearing loss (SNHL). Pearson correlation yielded strong
positive correlation with hearing loss and years of
exposure(p=<0.001). Male students used electroacoustic devices
more frequently than female students(p=0.01). However, we did not
observe significant difference between their mean thresholds.
Conclusion: Acoustic trauma has been conventionally described to affect
higher frequencies. We found low frequency SNHL among majority of
students. This indicates that specific type of acoustic trauma can
affect particular frequencies on audiogram. KEY WORDS: Low frequency
hearing loss, medical students, Pure Tone Audiometry, personal listening
devices, hearing thresholds, noise induced hearing loss, sensorineural
hearing loss
Vedolizumab-related arthralgias in patients with inflammatory bowel disease: A systematic review
Authors: Shimol Jennifer Ben , Tocut Milena , Guzman-Prado Yuli , Krespin Haim , Davidson Tima , Goddard-Zandman Gisele , Israeli Eran
Published: March 2022

Aim: Multiple papers have reported the development of new-onset
arthralgias with vedolizumab (VDZ) for the treatment of inflammatory
bowel disease (IBD). Other studies have shown that VDZ may help in
preexisting enteropathic spondyloarthropathy. We sought to probe this
issue by conducting a systematic review. Methods: Embase, Medline,
Cochrane Central, and Web of Science were searched up to June 29, 2020
for randomized controlled trials evaluating vedolizumab treatment in
patients with IBD in which development of arthralgias was noted. Risk of
bias and quality were assessed using Cochrane’s collaboration tool and
the GRADE system, respectively. PROSPERO registration number:
CRD42020197101. Results: Four hundred sixty-one discrete articles were
retrieved. Five studies (n=2,899) met inclusion criteria. Comparing the
risk of arthralgia in patients treated with VDZ and placebo yielded odds
ratio’s which ranged between 1.01 (95% confidence interval (CI)
0.61-1.65) and 10.20 (95% CI: 0.53-195.78). While each study noted an
increased incidence of arthralgias in patients receiving VDZ, none
proved statistically significant. Studies were heterogeneous in disease
populations, VDZ dosage, time-points for evaluation, and data points
collected. Post-hoc analyses suggested an increased risk of arthralgias
in patients with prior TNF inhibitor use. Conclusion: The included
studies showed a trend toward increased arthralgias in patients with IBD
who received VDZ. However, our study lacked any statistically
significant findings to identify a clear link. More research is needed
to substratify which patients develop arthralgias when treated with VDZ
in order to better understand whether heightened risk can be predicted
prior to treatment initiation.
The variation of air purification benefit provided by street tree assemblages in Shenyang, China
Authors: Yao Jing , Chen Wei , Liu Miao , Wang Xiaobo , He Xingyuan
Published: March 2022

Street trees assemblage is a widespread natural component in the cities
and provides a wide range of ecosystem services to the cities. However,
the distribution of street trees assemblage within a city is inequal. In
this paper, we took air purification benefit provided by street trees
for example to examine how urban form, urban geography and drivers of
vegetation management affect the variation of ecosystem services
provided by street trees in metropolitan Shenyang, Northeastern China.
The i-Tree Street (2018) was utilizing to evaluate air purification
benefit provided by street trees. We analyze the results using 2
indices: per kilometer benefit (PKB) and average tree benefit (ATB). The
results showed us that (1) both indices didn’t vary along the population
gradient. (2) The PKB had a decreasing trend along the urban-suburban
gradient. (3) The districts which had the highest PKB and ATB are
neither the old ones nor the newest one, but the districts start to
develop from around 2002 and 2003. Therefore, we infer that the public
policy is a main driver of vegetation management, especially for street
trees, because street tree is closely related to road/street development
which is closely related to economic development of a region. Besides,
there could be a time lag effect for ecosystem services provided by
trees.
Cat Que Virus (CQV): A potential threat of the tropics? “One Health Approach” to avert catastrophe: a narrative review
Authors: Ganesh Balasubramanian , Rajakumar Thangarasu , Vasumathy Sridharan , Sowmya Sridharan , Manikandan Natesan , Kaur Harpreet
Published: March 2022

The world is now experiencing the catastrophe of global pandemic
‘COVID-19’, most serious public health crises in this century. Recently,
another virus named “Cat Que Virus” (CQV) seems to be causing its
terrible repercussions in the worlds’ largest populous country ‘China’,
the origin of SARS-CoV during 2002-2003, and the current pandemic
SARS-CoV-2 since December 2019. Recently, the presence of IgG antibody
among two persons in the state of Karnataka for CQV was reported in
India, the worlds’ second-largest populous country. This means the virus
is in circulation in the sub-continent. The presence of the vector
mosquitoes (Aedes species, Culex species) and the ambient climatic
conditions suitable for vector breeding in the country needs to be taken
into account while planning to implement holistic strategies appropriate
for control and preventive measures. “One Health approach” is the
topmost option covering humans, animals/vectors and the environment to
curb the spread/transmission of infectious diseases in general. It is
also necessary to study the transmission dynamics and pattern of this
emerging virus, its life cycle, the natural reservoir of the virus, the
intermediate host and the accidental host with respect South-East Asia,
so that necessary remedial action can be planned well before an
epidemic. At present, the outbreak of CQV is certainly a warning to the
general population around the world. Considering the global imminent
health threats posed by CQV, there is an urgent need for active
surveillance, monitoring, effective vaccination, and a standard
treatment modality of this disease. Given the epidemiological aspect of
CQV, control and prevention measures are essential to stop the spread of
the virus. At present, there is no information available on CQV;
however, this current review article has covered the required data,
which will be helpful to control the spread of the CQV.
Do simulated patient interviews change attitudes towards communication skills training?
Authors: Tanrıverdi Esra Çınar , Senol Yesim
Published: March 2022

Aim: This study aimed to evaluate the attitudes of medical faculty
sophomore students towards communication skills training module consists
theory courses and simulated patient interviews. Methods: This study was
planned in before-and-after intervention study and was carried out with
257 second-year medical students. The Communication Skills Attitude
Scale (CSAS) were used for data collection. The scale was administered
to the participants before the training (1), after the training (2), and
after the simulated patient interviews (3). Results: The mean age of the
students was 20.13±2.13 years, and 133 (51.8%) of them were female. PAS
1 and PAS 3 scores were 55.38±6.58 and 58.05±7.39, respectively, while
NAS 1 and 3 scores were 30.25±4.49 and 28.88±4.96, respectively. PAS 3
was considerably higher than PAS 1 and 2 scores (p=0.037), while NAS 3
was significantly lower than NAS 1 and 2 scores (p=0.005). There was no
difference between the positive and negative attitudes of females and
males before the training. However, after the training, female’s
positive scores significantly increased compared to men, and their
negative scores decreased. Positive attitude scores of the female
students increased after both the theory course and the simulated
patient interviews. On the other hand, the negative attitude scores
decreased significantly after the simulated patient interviews
(p<0.05). Conclusion: Communication skills training improves
students’ attitudes. In this improvement, the contribution of simulated
patient interviews is more than theory instructions.
Complete resolution of alopecia totalis following chemotherapy treatment for B-cell acute lymphoblastic leukemia
Authors: L'Ecuyer Ariane , Ronsley Rebecca , Lam Joseph , Dix David
Published: March 2022

Alopecia totalis (AT) is a chronic disease that results in non-scarring
hair loss of the entire scalp. This results from an autoimmune reaction
involving the hair follicles due to genetic and environmental factors.
The clinical course of AT is highly unpredictable. There are limited
effective durable treatment options. Resolution of alopecia has been
reported post-autologous and allogenic hematopoietic stem cell
transplantation (HSCT). However, no cases of AT remission following
chemotherapy alone have been described. Here, we present a case of
complete remission of AT following chemotherapy for B-cell acute
lymphoblastic leukemia (B-ALL) in a pediatric patient.
AutoFusion of Feature Pruning via Disciplined Convex Concave Programming
Authors: Atas Pinar Karadayi , Akyuz Sureyya
Published: March 2022

Fusion of algorithms has recently taken attention in machine learning
studies because of its power coming from community decision instead of
single decision maker. One of the crucial questions in aggregation of
algorithms is that which and how many models should be combined to
achieve both best accuracy and low complexity. It is already knownn in
machine learning that as the complexity of the model increases too much,
prediction accuracy decreases. There is a trade of between these two
features. In order to answer such questions, diversity notion gets
involved to overall consensus models. It is also shown that diversity
alone does not determine the best ensemble (fusion), so accuracy and
diversity together has been taken into account recently in such
problems. In this paper, we took in account of those two notions
simultaneously so that number of algorithms and which algorithms should
be in the ensemble are answered while solving feature selection problem.
We have validated our algorithm on different domains of data sets which
shows better prediction accuracy values than existing ensemble based
feature selection methods.