bluuebunny/crossref_metadata_2025 huggingface dataset:
ORTOPOXVIRUSES: PAST, PRESENT AND FUTURE
Authors: Onishchenko Gennady , Kirillov Igor , Makhlai Alexander , Borisevich Sergei
Published: September 2020

The analysis of scientific publication, dedicated to human pathogenic orthopoxviruses over the past 40 years is generalizated. The essential activation of focies of monkeypox in Central Africa, cowpox in Europe, buffalopox in South-East Asia, camelpox in South-West and Central Asia and vaccinia-like viruses in Southern America is marked on the background of the apperance of three novel representatives of orthopoxviruses in North America (agents of volepox, raccoonpox and skunpox) and two representatives of African orthopoxviruses (agents of Uasingishu, named self-titled province of Kenya and taterpox).
It is concluded, that this is facilitated by almost complete absence of anti-smallpox immunity after the elimination of smallpox and stopping immunization in the world on the background of active human intervention in the nature.
Expert do not exclude, that as a result of a mutation of one of orthopoxviruses of animal, similar to smallpox virus agent will exist. Whereat the world will face a threat, much more serious that swine flu or avian flu.
It is concluded that modern scientific and methodological approachesto study of orthopoxvirus infections evolution allow to predict threats, related on biological safety of Russian Federation.
Psychiatric care organization and mental health disorders in people of countries affected by the COVID-19 pandemic 2020 (Review)
Authors: Tsygankov Boris , Ivanova Galina , Sheleg Dmitry , Savenkova Valeria
Published: September 2020

In the context of the COVID-19 pandemic, 50 patients and 30 medical personnel were infected in a psychiatric hospital in Wuhan (Hubei Province, China), which required the Ministry of Health of China to urgently analyze the situation and develop a set of measures aimed at containing the spread of the virus and organizing a full and safe psychiatric care.
The reasons for this situation could be the lack of reserve beds for psychiatric patients, low awareness of psychiatrists in diagnosing and treating infectious diseases, the separation of the psychiatric care system between the two departments, and the cramped living conditions of patients in psychiatric hospitals.
More than 500 psychiatrists from across the country were sent to Wuhan to fill staff. Psychiatric patients with mild to moderate COVID-19 were transferred to temporary psychiatric hospitals organized in gymnasiums and exhibition centers. Severely ill psychiatric patients COVID-19 were transferred to hospital infectious diseases. A single patient routing system was organized, a shift schedule for doctors was introduced. To reduce the burden on public transport, the outpatient unit of psychiatric care was taken to regional hospitals, which had previously dealt only with forensic psychiatry and the control of patients with addictive disorders.
Based on the experience of Wuhan, psychiatric communities from different countries proposed a list of practical recommendations designed to reduce the risks of spreading the infection and optimize the work of psychiatric care.
All hospitals should have a reserve bed capacity, which can be used for the rehabilitation and socialization of patients in quiet times. Hospitals must be provided with a sufficient number of tests, drugs, and personal protective equipment. Outpatients need to be fully provided with access to medical and psychotherapeutic therapy using telemedicine technologies to minimize the risk of infection. It is crucial to restructure the appointment of doctors by introducing work on a shift schedule: two weeks in two weeks, which will not only ensure a good rest but also allow doctors to be quarantined after each shift.
New Paradigm in Abilitation of Premature Children with Perinatal Pathology — Therapeutic Stages Personalization: Cohort Study
Authors: Baranov Alexander A. , Namazova-Baranova Leyla S. , Belyaeva Irina A. , Turti Tatiana V. , Vishneva Alexey A. , Molodchenkov Alexey I.
Published: September 2020

Background. The abilitation of premature infants acquires importance due to the increased prevalence of delayed health disorders in these children. The article considers the issues of individualization of rehabilitation treatment for premature infants according to prediction of perinatal pathology outcomes, determining the individual levels of «abilitation windows» and developing personalized abilitation programs.

Objective. The aim of the study was to determine individual timely sensitive ontogenesis stages («abilitation windows») for premature children with various perinatal pathology, as well as the most effective methods of rehabilitation treatment according to the maturity of the child and the type of neurosomatic deficiency.

Methods. Two-stage cohort study of premature children with gestational age of 250–6–300–6 weeks was conducted. Stage 1 — retrospective analysis of «abilitation windows» in 115 premature children, development of prognostic scenarios. Stage 2 — prospective cohort study of 109 premature children, using abilitation methods in this cohort according to predicted events and estimation of abilitation efficacy. Medical interventions: familyoriented educational counseling, kinesiotherapy, physiotherapy, neuroprotectors, music therapy.

Results. Information matrixes on filling ontogenetic abilitation periods have been developed, as well as age limits for «abilitation windows» have been defined on the 1st stage. Sensitive interval has been established for the use of stimulating effects in extremely immature children (postconceptional age of 34–37 weeks). The leading role of abilitation protective measures has been identified. Perinatal pathology outcomes have been analyzed in children from retrospective analysis group. Direct abilitation of premature children (from birth to 18 months) was carried out on the 2nd stage of the study according to probability forecasts. The priority of non-drug abilitation methods usage in immature children was confirmed. The need in step-by-step dynamic correction of abilitation programs was established.

Conclusion. Prognostic significance of perinatal period events and individual postconceptional age in «abilitation windows» development for premature children was determined. The priority of non-drug abilitation for such patients (including family-oriented pedagogics) is established.
Hearing Loss Effect on the Educational Process in Children and Adolescents
Authors: Pashkov Aleksandr V. , Namazova-Baranova Leyla S. , Vishneva Elena A. , Naumova Irina V. , Zelenkova Irina V.
Published: September 2020

There are about 466 million people (6.1% of global population) with hearing impairment registered in the world according to the data from WHO experts. Their number exceeds 13 million in Russian Federation, and more than 1 million are children. The results of the universal audiological screening program for newborns has shown that 1 child per 1000 newborns is born deaf, another 2–3 children grow deaf during the first years of life. The number of people with hearing impairment will reach 900 million people by 2050 according to the WHO forecasts. Prevention and early diagnosis of hearing loss and rehabilitation of children with such disorders are necessary for avoiding problems with social integration. This review presents the analysis of cognitive abilities development in children and adolescents with different types and degrees of hearing loss with regard to different approaches in their management and rehabilitation.
Resolution of the International meeting of experts on the exchange of scientific experience in the use of anticoagulants in patients with COVID-19
Authors: Avdeev S. N. , Bazarova A. V. , Baranova E. I. , Esayan A. M. , Zhusupova G. K. , Zamyatin M. N. , Zotova I. V. , Kasenova S. L. , Matskeplishvili S. T. , Miller O. N. , Pak A. M. , Salukhov V. V. , Tyrenko V. V. , Khasanova D. R. , Shamalov N. A. , Yanishevsky S. N.
Published: September 2020

С целью получения экспертного мнения по вопросам, связанным с актуальностью, протоколами и режимами антитромботической терапии у пациентов с COVID-19 на госпитальном и амбулаторном этапах лечения 25 июля 2020г была проведена Международная он-лайн встреча экспертов по научному обмену опытом.

Группа экспертов различных специальностей (кардиологи, неврологи, эндокринологи, анестезиологи-реаниматологи), имеющих клинический опыт лечения пациентов с COVID-19, ответила на вопросы, касающиеся использования антикоагулянтов на различных этапах оказания помощи при COVID-19. Учитывая недостаточное количество структурированной научной информации, отсутствие рандомизированных контролируемых исследований в области использования антикоагулянтов у пациентов с COVID-19, наличие различных мнений в профессиональных медицинских сообществах было принято решение провести голосование с использованием Дельфийского метода экспертных оценок и прогнозирования. На первом этапе для экспертов формировались вопросы, которые касались нескольких областей терапии: тактика ведения больных, постоянно принимавших антикоагулянты до заболевания COVID-19, назначение антикоагулянтной терапии больным по поводу COVID-19 и особенности назначения антикоагулянтной терапии у больных с высоким риском венозной тромбоэмболии при COVID-19. После утверждения списка вопросов проводилось анонимное анкетирование экспертов вне очной встречи и затем обрабатывались полученные результаты, определяя обычное большинство при голосовании по каждому вопросу.
“…In the immortal forms of beauty”: Frédéric Chopin seen through the eyes of the father of Brazilian neurological semiology
Authors: PEDRO Matheus Kahakura Franco , SOUZA Thiago Ferreira Simões de , GERMINIANI Francisco Manoel Branco
Published: September 2020

ABSTRACT Aloysio de Castro (1881-1959) is now remembered as one of Brazil's greatest physicians and is considered the father of Brazilian neurological semiology. However, his interests went far beyond the realm of Medicine, and he became one of the most illustrious intellectuals of his time. In 1927, he gave a speech at the São Paulo Society of Artistic Culture on Frédéric Chopin and embarked on a journey across the composer's life and times, discussing the medical issues involving his death, as well as his lovers, his compositions, and the spiritual aspects of musical interpretation. Thus, Castro reinforced the bonds of music and Medicine and provided lessons on Musicology that may very well be as suited to a hospital as they are to a concert hall.
Control of root rot (Phytophthora cinnamomi) in avocado (Persea Americana) with bioagents
Authors: Sumida Ciro Hideki , Fantin Lucas Henrique , Braga Karla , Canteri Marcelo Giovanetti , Homechin Martin
Published: September 2020

ABSTRACT Despite the favorable edaphoclimatic conditions for avocado production in Brazil, diseases such as root rot caused by the pathogen Phytophthora cinnamomi compromise the crop. With the aim of managing root rot in avocado, the present study aimed to evaluate chemical and biological control with isolates of Trichoderma spp. and Pseudomonas fluorescens. Thus, three assays were conducted to assess: (i) mycelial inhibition of P. cinnamomi by isolates of Trichoderma spp. and P. fluorescens from different crop systems; (ii) effect of autoclaved and non-autoclaved metabolites of P. fluorescens, and (iii) chemical or biological treatment of avocado seedlings on the control of root rot under field conditions. The isolates of Trichoderma spp. from maize cultivation soil and the commercial products formulated with Trichoderma presented greater antagonism (p <0.05) to the pathogen P. cinnamomi in the in vitro tests. Similarly, non-autoclaved metabolites of P. fluorescens presented antagonistic potential to control P. cinnamomi. Under field conditions, the fungicide metalaxyl and the bioagents showed effectiveness in controlling P. cinnamomi, as well as greater root length and mass. Results demonstrated potential for the biological control of avocado root rot with Trichoderma spp. and P. fluorescens.
Bioatividade de óleos essenciais e extratos vegetais no controle de doenças causadas por Phytophthora nicotianae em solanáceas
Authors: Pimenta Neto Antônio Alves , Gonçalves Gláucio Dias , Benjamin Carolina Santos , Costa Larissa Corrêa do Bomfim , Oliveira Rosilene Aparecida de , Oliveira Sônia Maria Alves de , Luz Edna Dora Martins Newma
Published: September 2020

RESUMO Óleos essenciais (EO) e extratos brutos aquosos (EBA) de Syzygium aromaticum e Cymbopogon nardus, e seus principais componentes químicos foram investigados para controle in vitro e in vivo de doenças causadas por Phytophthora nicotianae em tomateiro (Lycopersicon esculentum) e berinjela (Solanum melongena). Experimentos in vitro foram conduzidos pelo método de diluição em ágar com diferentes concentrações de óleos essenciais (OE’s) (0,1; 0,5; 1,0 ?L/mL) e extratos aquosos brutos (EBA’s) (1,0; 10,0 20,0%) para avaliar o potencial inibitório sobre o crescimento micelial e germinação de zoósporos. Com as porcentagens de inibição e concentrações inibitórias mínimas encontradas, realizou-se testes em frutos e plântulas sob ambiente controlado. As variáveis avaliadas foram o diâmetro médio das lesões formadas na superfície dos frutos e a incidência e morte de plântulas ao longo de seis e 15 dias de avaliação, respectivamente. Os produtos que mais inibiram o crescimento micelial e a germinação de zoósporos foram obtidos de S. aromaticum, nas concentrações de 0,5 ?L/mL e 10% de OE e EBA, respectivamente. Os tratamentos que mais retardaram a progressão da doença em frutos e plântulas, em comparação com o controle, foram o OE e EBA de C. nardus a 1,0 ?L/mL e 20%, respectivamente. Portanto, os produtos obtidos de S. aromaticum e C. nardus, têm potencial para reduzir o ataque deste patógeno em tomate e berinjela.
Conhecimento, ética e política: premissas da Pós-graduação
Authors: Lewgoy Alzira Mª Baptista , Fernandes Rosa Maria Castilhos , Reidel Tatiana
Published: September 2020

Resumo: O artigo considera dois importantes desafios como forma de demonstrar o compromisso do Programa de Mestrado em Política e Serviço Social com, a saber: a construção de conhecimentos, em defesa da classe trabalhadora como um desafio permanente; e a implicação ética e política para produção de conhecimento como premissa para a formação no PPG.
Desenvolvimento de pesquisas no Nordeste e a importância das Fundações de Amparo (2014-2016)
Authors: Santos Vera Núbia , Gonçalves Maria da Conceição Vasconcelos , Silva Noêmia Lima
Published: September 2020

Resumo: A FAP é corresponsável pelo desenvolvimento científico, tecnológico e a inovação no país. Com o levantamento e análise de editais publicados no site das nove FAPs da região Nordeste, constatou-se o total de 316 editais entre 2014 e 2016. Observa-se, em sua maioria, apoio para eventos, publicações e programas de pós-graduação, além de pesquisas. O Serviço Social deve atentar para a importância dessa agência de fomento, na perspectiva da qualidade da formação e do exercício profissional.
The design of the certification service of quality management systems ISO 9001: a case study in a military organization of the Brazilian Navy
Authors: Sousa Antonelly Assis Gregorio de , Lima Manoel Paulo da Silva , Fermam Ricardo Kropf Santos
Published: September 2020

Abstract: The Brazilian Navy is preparing to design, build and repair nuclear submarine. One of the initiatives adopted was the creation of the Naval Agency for Nuclear Safety and Quality (AgNSNQ) which aims to assist the licensing of nuclear and naval facilities and conformity assessment of Quality Management Systems. The concept of the certification service of management systems needs to be evaluated, before expending resources and people to develop. This article aimed to assess the characteristics of AgNSNQ to design the ISO 9001 QMS certification service through the service project model. A case study was conducted to evaluate the characteristics of the AgNSNQ concerning the criteria. The article's contributions indicate that AgNSNQ should primarily promote efforts to train its auditors to create favorable conditions for designing the ISO 9001 QMS certification service.
Propriedade intelectual do soro antiofídico: a efetividade a partir da correlação entre os investimentos do governo federal nos principais institutos responsáveis pela produção do soro e realização de pesquisas para o tratamento de acidentes ofídicos no brasil, com relação ao número de vítimas fatais dos acidentes
Authors: Vaz Vitor Hugo da Silva , Brazil Osiris Ashton Vital , Paixão Ana Eleonora Almeida
Published: September 2020

Resumo Introdução O envenenamento por picada de serpentes é um latente problema de saúde pública em nível global. Neste contexto, o Brasil se apresenta como referência mundial no tratamento deste tipo de acidente. É importante destacar que o tratamento de acidentes ofídicos no país foi evidenciado a partir dos estudos do sanitarista Vital Brazil, que patenteou o tratamento e doou para o Estado brasileiro. Mas, qual o impacto este ato gerou para a sociedade, já que a gestão da patente se tornou obrigação do Estado? Objetivo A partir de uma análise da evolução do tratamento do ofidismo, verificar a correlação entre os investimentos do Governo Federal nos principais institutos responsáveis pela produção do soro e realização de pesquisas para o tratamento de acidentes ofídicos no Brasil, com relação ao número de vítimas fatais dos acidentes. Método Realizou-se uma análise de correlação estatística, tendo como base acidentes e óbitos decorrentes dos acidentes ofídicos e os investimentos do governo nos principais institutos produtores de soros antipeçonhentos, no período de 1998 a 2017. Resultados Os resultados mostraram que há uma franca evolução no número de acidentes decorrentes dos acidentes ofídicos no Brasil entre 1998 e 2017. Conclusão Existe correlação positiva entre os investimentos do Governo Federal nos principais institutos responsáveis pela produção do soro e realização de pesquisas para o tratamento de acidentes ofídicos no Brasil, com relação ao número de vítimas fatais dos acidentes.
Hipertensos assistidos em serviço de atenção secundária: risco cardiovascular e determinantes sociais de saúde
Authors: Nobre André Luiz Cândido Sarmento Drumond , Lima Cássio de Almeida , Oliveira Maria José Lages de , Vieira Davi de Melo Alvarenga , Martelli Júnior Hercílio , Costa Simone de Melo
Published: September 2020

Resumo Introdução Na perspectiva dos determinantes sociais de saúde, a Hipertensão Arterial Sistêmica apresenta complexa natureza multifatorial. É fator de risco cardiovascular, influenciado por aspectos comportamentais, econômicos, sociais, políticos e ambientais. Objetivo Investigar a relação entre determinantes sociais de saúde e risco cardiovascular global em hipertensos assistidos em serviço da atenção secundária do Sistema Único de Saúde. Método Estudo seccional analítico, com pacientes do Centro Hiperdia, no norte de Minas Gerais, Brasil. Dados de determinantes sociais foram coletados por meio de questionário estruturado. A classificação do risco cardiovascular (alto, moderado e baixo) deu-se a partir de dados clínicos. A estatística considerou nível de significância 5%. Resultados Entre 231 participantes, a maioria (64,1%) era de alto risco cardiovascular, associado aos dados clínicos: elevada pressão arterial sistólica (p=0,04) e maior tempo de diagnóstico (p=0,01). O alto risco cardiovascular foi associado aos determinantes sociais: satisfação com acesso aos serviços de saúde (p=0,02) e ambiente físico saudável (p=0,02). Conclusão Apesar de a satisfação com os serviços de saúde e com o ambiente físico terem apresentado resultados reversos, sugere-se fortalecer políticas e práticas de atenção à saúde, que reconheçam diferentes determinantes e previnam a gravidade do risco cardiovascular.
Phytochemical analysis and biological activities of ethanolic extract of Curcuma longa rhizome
Authors: Sabir S.M. , Zeb A. , Mahmood M. , Abbas S.R. , Ahmad Z. , Iqbal N.
Published: September 2020

Abstract Curcuma longa is an important dietary plant which possess several pharmacological activities, including antioxidant, antimicrobial, anti-inflamatory, anticancer and anti clotting etc. The aim of the present study was to determine the phenolic profile of Curcuma longa and in vitro antioxidant and antidiabetic activities. In HPLC chromatogram of Curcuma longa rhizome extract 15 phenolic compounds were identified namely Digalloyl-hexoside, Caffeic acid hexoside, Curdione, Coumaric, Caffeic acid, Sinapic acid, Qurecetin-3-D-galactoside, Casuarinin, Bisdemethoxycurcumin, Curcuminol, Demethoxycurcumin, and Isorhamnetin, Valoneic acid bilactone, Curcumin, Curcumin-O-glucuronide respectively. The ethanolic extract displayed an IC50 value of 37.1±0.3 µg/ml against alpha glucosidase. The IC50 value of DPPH radical scavenging activity was 27.2 ± 1.1 μg/mL. It is concluded that ethanolic extract of Curcuma long is rich source of curcumin and contain several important phenolics. The in vitro antioxidant and alpha glucosidase inhibitory effect of the plant justifies its popular use in traditional medicine.
Seasonal abundance and distribution of dragonflies in upper Siran valley of District Mansehra Pakistan
Authors: Mehmood S. A. , Zia A. , Ahmed S. , Panhwar W. A. , Khan W. , Shah M. , Ullah Irfan
Published: September 2020

Abstract Present study was conducted to study seasonal abundance and distribution of dragonflies in upper Siran valley district Mansehra Pakistan. To collect data, eleven localities were visited for three consecutive years (2016-2018). Results come up with a sum of 300 specimens identified under three families, eight genera and twenty species. Highest seasonal abundance recorded during summer and spring were 80.67% and 13.33% respectively while minimum 6.00% was recorded during early autumn. Dominant species observed were, Orthetrum chrysis (14.00%), followed by O. gluacum (12.00%), Palpoleura sexmaculata sexmaculata (11.33%) and O. cancellatum cancellatum (8.00%). However the highest population of dragonflies was found in Munda Gucha with a percentage of 11.33 followed by Jabbar (11.00%) and Sachan (9.67%). The lowest populations were recorded in Suham (6.00%), Dadar (7.67%) and Jabori (7.67%). The surveyed valley showed diverse Anisopterous fauna and thus further extensive surveys are recommended that can come up with more important species from the area.
Histopathological alterations in gills, liver, kidney and muscles of Ictalurus punctatus collected from pollutes areas of River
Authors: Shahid S. , Sultana T. , Sultana S. , Hussain B. , Irfan M. , Al-Ghanim K. A. , Misned F. A , Mahboob Shahid
Published: September 2020

Abstract Untreated sewage and industrial wastes from Faisalabad city are disposed to River Chenab through Chakbandi Main Drain (CMD). The present project is planned to investigate the effects of this freshwater pollution on the body of fish Ictalurus punctatus. The specimens of this fish species were collected upstream and downstream of the entrance of CMD into River Chenab. Fish gills, liver, kidney and muscles from dorsolateral regions of fish were subjected to histopathology. Farmed fish and fish from upstream areas were used as control. Fish collected from polluted experimental sites showed significant damage in selected organs. Gill tissues showed an abnormality in the form of an uplifting of the primary epithelium, fusion, vacuolation, hypertrophy, and necrosis. While liver tissues subjected to hepatocytes degeneration, necrosis, mitochondrial granular hepatocyte, and sinusoids dilation. Kidney tissues indicated increased bowmen space and constricted glomerulus and degenerated nephrons. Edema, necrosis, and atrophy were observed in muscle tissues of fish from polluted areas. Fish from the upstream area showed fused gill lamellae, inflammatory cell infiltration, hypertrophy and vacuolation in hepatocytes. Kidney tissues indicated the presence of nuclear tubular cells, destructive renal tubules, hemorrhage, and necrosis at tubular epithelium. Intra myofibril spaces were also observed in muscles. Specimens of control fish indicated no variation in gills, liver, kidney, and muscles. The present study revealed a strong correlation between the degree of tissue damage and environmental contamination. Present findings also compel global warnings to protect our water bodies and fish to rescue the human population.
An inventory of Ichthyofauna of the Pindaré River drainage, Mearim River basin, Northeastern Brazil
Authors: Guimarães Erick C. , Brito Pâmella S. de , Gonçalves Cléverson S. , Ottoni Felipe P.
Published: September 2020

Abstract: In the present work, we conducted an extensive long-lasting inventory of the fishes, using different collection methodologies, covering almost the entire Pindaré River drainage, one of the principal tributaries of the Mearim River basin, an area included in the Amazônia Legal region, northeastern Brazil. We reported 101 species, just three of them being non-native, demonstrating that the composition of this studied fish community is majority composed of native species. We found a predominance of species of the orders Characiformes and Siluriformes, corroborating the pattern usually found for the Neotropical fish fauna. Similar to other studies, this inventory was mainly dominated by small characids, representing 21% of the species herein recorded. When comparing the present survey with other species lists published for this region (including the States of Maranhão and Piaui), we can conclude that the freshwater fish fauna of the State of Maranhão is probably still underestimated. We reported 41 more species, and one more species than Soares (2005, 2013) and Abreu et al. (2019) recorded for the entire Mearim River basin, respectively. We believe, however, that the number of species presented by Abreu et al. (2019) is overestimated. We compared our results with all other freshwater fish species inventories performed for the hydrological units Maranhão and Parnaíba sensu Hubbert & Renno (2006). With these comparisons, we concluded that our results evidenced that a high effort was put in the inventory here presented. The two works including more species recorded from coastal river basins of the hydrological units Maranhão and Parnaíba were the works published by Ramos et al. (2014) for the Parnaíba River basin, one of the main and larger river basin of Brazil, and the compiled data published by Castro & Dourado (2011) for the Mearim, Pindaré, Pericumã, and upper Turiaçu River drainages, including 146 and 109 species, respectively. Our survey recorded only 45 less species than Ramos et al. (2014), and eight less species than Castro & Dourado (2011). However, it is essential to emphasize that the number of species presented by Castro & Dourado (2011) is probably overestimated since they did not update and check the taxonomic status of the species of their compiled data. In several cases, they considered more than one name for the same species.
Síndrome do aprisionamento da artéria tibial anterior bilateral pelo retináculo extensor do tornozelo: relato de caso
Authors: Engelhorn Ana Luiza Dias Valiente , Miranda Anna Luiza Cauduro de , Biglia Luiz Eduardo , Castilho Rafaella , Machado Sarah Folly Polonio , Abrão Maurício Henrique , Engelhorn Carlos Alberto
Published: September 2020

Resumo Os aprisionamentos vasculares são raros. Nos membros inferiores, geralmente são assintomáticos, mas podem causar claudicação intermitente atípica em indivíduos jovens sem fatores de risco para aterosclerose ou doenças inflamatórias. O vaso mais frequentemente acometido é a artéria poplítea, causando a síndrome do aprisionamento da artéria poplítea (SAAP), com sintomas na região dos músculos infrapatelares. Quando o desconforto ao esforço é mais distal, deve-se pensar em outros locais de aprisionamento arterial, como a artéria tibial anterior. Neste trabalho, é relatado o caso de um paciente com claudicação intermitente nos pés devido ao aprisionamento da artéria tibial anterior (AATA) bilateral, causado pelo retináculo dos músculos extensores e diagnosticado pela ultrassonografia vascular e angiotomografia durante flexão plantar. O paciente foi tratado cirurgicamente, evoluindo com melhora dos sintomas clínicos.
Pseudoaneurisma traumático em artéria braquial após retirada de implante contraceptivo subdérmico
Authors: Monteiro Rafael Borges , Metzger Patrick Bastos , Moura Ariadne Bonachela de , Silva Filho Antonio Herculano , Campos Matheus Nogueira , Brito Arthur Suana de , Luengo Mirella Prado , Nascimento Maria Júlia Andrade
Published: September 2020

Resumo Os procedimentos terapêuticos invasivos têm aumentado frequentemente com a evolução da medicina, consequentemente aumentando o número de complicações decorrentes deles. O dispositivo contraceptivo subdérmico (DCS) tem um benefício para a contracepção feminina, mas o implante e a retirada apresentam uma taxa de complicações em torno de 3%. Neste artigo, relatamos e discutimos um caso de pseudoaneurisma traumático da artéria braquial após tentativa de retirada do implante, complicada com a compressão do nervo mediano.
MUDANÇA E INOVAÇÃO ORGANIZACIONAL: ESTUDO DE CASO EM UMA EMPRESA DO CLUSTER DE BIOTECNOLOGIA EM MINAS GERAIS
Authors: CASTRO JOSÉ MÁRCIO DE , BASQUES PAULA VALADARES
Published: September 2020

RESUMO Este artigo analisa o processo de mudança organizacional planejada em uma empresa familiar de base tecnológica e os fatores internos e externos mais relacionados ao processo. Procurou-se ainda compreender como o processo de mudança alterou quatro importantes dimensões organizacionais: pessoas, estrutura organizacional, processos gerenciais e as estratégias empresariais. Além de fatores de natureza endógena, fatores exógenos também influenciaram o processo de mudança experimentado pela empresa em análise. A partir do pressuposto de que processos dessa natureza geralmente estão relacionados a crises, a pesquisa aponta para uma atitude mais proativa da empresa analisada, que se antecipou a uma crise mais profunda e empreendeu mudanças que efetivamente contribuíram para alavancar seus negócios.
POSSÍVEL REAÇÃO DO MERCADO BRASILEIRO AOS INVESTIMENTOS EM P&D
Authors: CRISÓSTOMO VICENTE LIMA , GONZÁLEZ ELEUTERIO VALLELADO
Published: September 2020

RESUMO A importância dos ativos intangíveis é crescente no cenário econômico atual, o que faz com que muitas pesquisas sejam dedicadas a eles. Nesse contexto está a avaliação da capacidade de criação de valor de tais ativos, com destaque para Pesquisa e Desenvolvimento (P&D). Já há muitas pesquisas sobre esse tema nos Estados Unidos, sendo escassa, no entanto, em mercados em desenvolvimento. Este trabalho tem como objetivo apresentar uma pesquisa sobre possível efeito econômico de investimentos em P&D nas empresas brasileiras. Para tanto se fez uma revisão bibliográfica sobre a questão em nível mundial e procedeu-se a uma pesquisa empírica nas empresas brasileiras listadas na Bovespa. Apesar dos baixos níveis de investimentos em P&D encontrados, verificou-se sinal de uma sensibilidade positiva do mercado brasileiro com relação aos gastos das empresas em P&D, o que pode ser um indicativo de que esse mercado considera estes como investimentos capazes de gerar benefícios futuros. Adicionalmente se aponta a necessidade de utilização de outros modelos, bem como também a consideração de outros fatores para amadurecer a questão que tem sido motivo de extensa pesquisa em outros mercados.
AVALIAÇÃO DA ESCALA CONSUMER STYLE INVENTORY (CSI) NO CONTEXTO BRASILEIRO
Authors: SANTOS CRISTIANE PIZZUTTI DOS , FERNANDES DANIEL VON DER HEYDE
Published: September 2020

RESUMO O objetivo deste estudo é a avaliação, no contexto brasileiro, da escala Consumer Style Inventory (CSI), desenvolvida por Sproles e Kendall (1986), que investiga os estilos de tomada de decisão dos consumidores. A presente pesquisa tem como foco os jovens, uma vez que poucos estudos têm investigado a tomada de decisão desta população, apesar de as experiências vivenciadas na adolescência influenciarem o comportamento dos indivíduos durante sua vida adulta e do fato de os adolescentes serem cada vez mais responsáveis por suas decisões de consumo e influenciarem fortemente as decisões familiares. Desta forma, a partir de um survey com 464 adolescentes, a escala foi avaliada, purificada e validada. Primeiramente, por meio de verificações da validade de conteúdo. Após, a amostra foi dividida aleatoriamente em duas: a primeira serviu à purificação das medidas e a segunda, à validação do modelo de mensuração. Os resultados indicam, de modo geral, um agrupamento bastante similar ao do estudo inicial e a confiabilidade e validade do instrumento no ambiente testado, com pequenas adaptações necessárias - um item de cada um dos seguintes estilos: orientados pela moda, pela marca, hedônico, e dois itens do estilo impulsivo revelaram fraca diferenciação entre os fatores, fraca identificação com seus respectivos estilos ou, ainda, indicaram melhoria significativa do modelo de medidas ao serem retirados, justificando a sua exclusão.
Sleep and immunity in times of COVID-19
Authors: Silva Eduardo de Sousa Martins e , Ono Ben Hur Vitor Silva , Souza José Carlos
Published: September 2020

SUMMARY BACKGROUND Analyze how the COVID-19 (SARS-CoV-2) pandemic and its social restriction measures affect sleep quality and the immunological system. METHODS An integrative bibliographical review was carried out using scientific articles from the last five years, from the PUBMED databases, with the descriptors: Sleep; Quarantine; COVID-19; Immunity; Mental Health. Besides the books "Oxford textbook of sleep disorders", "Cellular and molecular immunology", and "Treaty of Infectology". RESULTS Sleep affects immunity. This happens through the regulation of immunological markers and their cells. Therefore, the COVID-19 pandemic can promote sleep disturbances and harm the immune system function. CONCLUSION Sleep exercises a direct influence on immunity maintenance and immunological response. Circadian rhythm alterations, associated with the psychological problems imposed by the COVID-19 pandemic compromise the quality of sleep and, for that reason, the immune system.
Risk of venous thromboembolism in users of contraception and menopausal hormone therapy during the COVID-19 pandemic
Authors: Pires Andréa Larissa Ribeiro , Batista José Gomes , Aldrighi José Mendes , Massaia Irineu Francisco Delfino Silva , Delgado Diego Medeiros , Ferreira-Filho Edson Santos , Soares-Junior José Maria
Published: September 2020

SUMMARY OBJECTIVES The outbreak of coronavirus disease (COVID-19) is a public health emergency of international concern. Inflammatory changes are part of COVID-19 pathophysiology and this might generate a higher thromboembolic risk in patients using combined hormonal contraception and menopausal hormone therapy. We aimed to discuss the main aspects related to this issue and propose management strategies for women affected by COVID-19. METHODS This narrative review collected information from several articles published since the beginning of the outbreak of the new coronavirus disease about the pathophysiology, stage of the disease, the occurrence of thrombotic events, and the risk of thromboembolism in users of contraception and hormonal therapy. RESULTS This article consolidates clinical parameters about the risk of venous thromboembolism in users of contraception and menopausal hormone therapy emphasizing the probable increase of that risk in women with suspected or confirmed COVID-19 and bringing safer recommendations. CONCLUSIONS In this scenario, apart from the fundamental orientations of preventive measures, like social isolation and hygiene, it is important that all female health professionals have knowledge of the new rules and adopt safety measures, especially on the prescription of hormonal therapy and contraception.
COVID-19 and acute myocarditis: current literature review and diagnostic challenges
Authors: Çınar Tufan , Hayıroğlu Mert İlker , Çiçek Vedat , Uzun Mehmet , Orhan Ahmet Lütfullah
Published: September 2020

SUMMARY INTRODUCTION In the current literature, there has been an upsurge of cases of COVID-19-induced acute myocarditis. In this case-based review, we aimed to describe the clinical characteristics, imaging findings, and in-hospital course of acute myocarditis. In addition, the limitations of the myocarditis diagnosis were discussed since only fulminant myocarditis cases have been mentioned in the current literature. METHODS We performed a review of the literature of all patients who were diagnosed with COVID-19-induced acute myocarditis using the databases of PubMed, Embase, and the Cochrane. RESULTS 16 case reports were found to be related to COVID-19-induced acute myocarditis. We observed that the ECG findings in most of the COVID-19 patients were non-specific, including diffuse ST-segment elevation, non-specific intraventricular conduction delay, sinus tachycardia, and inverted T-waves in anterior leads. Echocardiographic findings of COVID-19-induced acute myocarditis patients ranged from preserved left ventricular ejection fraction (LVEF) without segmental abnormalities to reduced LVEF with global hypokinesia. Interestingly, a few patients with COVID-19-induced acute fulminant myocarditis were steroid-responsive and had an amelioration with glucocorticoid and immunoglobulin therapy. CONCLUSION Despite the COVID-19 pandemic worldwide, a limited number of cases has been shared in the current literature. There are a lot of difficulties in the differential diagnosis of acute myocarditis in the context of COVID-19.
Ventilation mask adapted for endoscopy during the COVID-19 pandemic
Authors: Paccos José Luiz , Lima Ivandro Paulo de , Lima Viviane Rissio Borba de , Mukai Natália Sayuri
Published: September 2020

SUMMARY In the context of the COVID-19 pandemic, endoscopy services must adopt preventive measures to maintain proper functioning due to a high risk of disease contagion. Triage protocols before and after the procedure, personal protective equipment, and environmental contamination control are some of the endoscopy society’s recommendations. However, the risk of infection may remain high due to poor control over the source of contamination.Using a combination of standardized supplies and accessories in a hospital, a ventilation mask adapted to be used in endoscopic procedures is proposed to reduce COVID-19 contamination.
Impact of antihypertensive agents on clinical course and in-hospital mortality: analysis of 169 hypertensive patients hospitalized for COVID-19
Authors: Kocayigit Ibrahim , Kocayigit Havva , Yaylaci Selcuk , Can Yusuf , Erdem Ali Fuat , Karabay Oguz
Published: September 2020

SUMMARY OBJECTIVE Coronavirus disease 2019 (COVID-19) is an emerging health threat caused by a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). Previous studies have noted hypertension is associated with increased mortality due to COVID-19; however, it is not clear whether the increased risk is due to hypertension itself or antihypertensive agents. We aimed to evaluate the impact of antihypertensive agents on the clinical outcomes of hypertensive patients with COVID-19. METHODS Our study included 169 consecutive hypertensive patients hospitalized due to COVID-19 between March 20 and April 10, 2020. The demographic characteristics, clinical data, and type of antihypertensive agents being used were reviewed. RESULTS The mean age of patients was 65.8±11.7 years.30 patients(17.7%) died during hospitalization. A total of 142 patients(84%) were using angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs), 91 (53.8%) were using diuretics, 69 (40.8%) were using calcium channel blockers (CCBs), 66 (39.1%) were using beta-blockers, 12 (7.1%) were using alpha-blockers, and 5 (2.9%) were using mineralocorticoid receptor antagonists (MRAs). There was no significant difference between survivors and non-survivors based on the type of antihypertensive agents being used. Binary logistic regression analysis showed that the type of the antihypertensive agent being used had no effect on mortality [OR=0.527 (0.130-2.138), p=0.370 for ACEIs/ARBs; OR=0.731 (0.296-1.808), p=0.498 for CCBs; OR=0.673 (0.254-1.782), p=0.425 for diuretics; OR=1.846 (0.688-4.950), p=0.223 for beta-blockers; OR=0.389 (0.089-1.695), p=0.208 for alpha-blockers; and OR=1.372 (0.107-17.639), p=0.808 for MRAs]. CONCLUSION The type of antihypertensive agent being used had no effect on the clinical course and mortality in hypertensive patients with COVID-19. The use of these agents should be maintained for the treatment of hypertension during hospitalization.
The effect of abo and rh blood group antigens on admission to intensive care unit and mortality in patients with COVID-19 infection
Authors: Yaylacı Selçuk , Dheir Hamad , İşsever Kubilay , Genc Ahmed Bilal , Şenocak Didar , Kocayigit Havva , Guclu Ertugrul , Suner Kezban , Ekerbicer Hasan , Koroglu Mehmet
Published: September 2020

SUMMARY AIM The aim of this study is to analyze the prognostic significance of ABO and Rh blood group antigens along with various parameters in patients followed-up with the diagnosis of COVID-19. METHODS We evaluated 397 patients who were follow-up and treated due to COVID-19 infections. The ages, genders, chronic diseases, ABO and Rh blood group antigens, admission rates to Intensive Care Units (ICU), and mortality rates of the patients were analyzed. FINDINGS The mean age of the 397 patients with COVID-19 was 47±17 years. In the blood group analysis of the patients, A Rh-positive (A +) was the most frequently seen blood type (176 patients, 44.3%) followed by O Rh-positive (0 +) (109 patients, 27,5%); 38 patients were Rh negative (Rh -) (9,6%). 53 of the patients (13,4%) were followed in ICU and 29 patients died (7,3%). Neither mortality nor admission to ICU was seen for Rh – group. The comparison of Rh groups concerning the need for ICU admission revealed a significantly high rate of ICU admission in the Rh + group (p=0,011), while no significant relationship was found between mortality and Rh antigen (p=0,069). CONCLUSION The most frequently seen blood type among COVID-19 patients was A +. The Rh + blood group was found in all cases who were admitted to ICU and had a death outcome. The Rh + blood group was found in a significantly high number of patients who were admitted to ICU, while no significant relationship was found between mortality and Rh blood group.
CONSTRUÇÃO DE UM INDICADOR QUANTITATIVO (STATUS DE SAÚDE) PARA AVALIAÇÃO DA QUALIDADE DE SAÚDE ANIMAL DE PROPRIEDADES RURAIS
Authors: Padovani C.R. , Stachissini A.V.M , Costa H.F. da , Aragon F.F. , Modolo J.R.
Published: September 2020

RESUMO Visando à construção de uma ferramenta de trabalho que permitisse expressar a grandeza da saúde animal de propriedades rurais, foi construído um indicador resultante da qualidade da saúde do rebanho denominado “status de saúde animal”. Como exemplo para a construção do indicador, tomaram-se os soros de 923 caprinos oriundos de 17 capris do Estado de São Paulo, nos quais se avaliaram três enfermidades e seus respectivos impactos percentuais: a artrite-encefalite caprina, a neosporose e a toxoplasmose - todas de caráter infeccioso e transmissível e que ocasionam consideráveis perdas econômicas. A lógica da construção matemática do “status de saúde animal” classifica a propriedade numa variação de 0 a 100%, conforme a positividade das enfermidades no rebanho: quanto maior a frequência acumulativa de ocorrência das doenças nos animais, menor o valor do indicador, chegando ao limite de 0% - quando todos os animais estiverem positivos às três enfermidades e de 100% - quando todo o rebanho for negativo. Para detecção de anticorpos anti-T. gondii, anti-N. caninum e anti-CAEV, foram utilizados, respectivamente, reação de imunofluorescência indireta (RIFI ≥ 16), teste de aglutinação para Neospora (NAT ≥ 25) e imunodifusão em gel de agarose (IDGA positivo ou negativo). O “status de saúde animal” das propriedades rurais variou de 32,38% a 96,40%, de acordo com a ocorrência de positividade para as enfermidades. A característica do valor do “status de saúde animal” terá reflexo direto na cadeia de produção dentro e fora da fazenda, proporcionando não somente enormes vantagens mercadológicas, devido à expressão que a saúde animal terá para agregar valor às propriedades rurais de produção animal, mas também no consumidor final que poderá verificar a qualidade da saúde animal no início da cadeia de produção.
COMPATIBILIDADE DE METARHIZIUM ANISOPLIAE COM CARRAPATICIDAS QUÍMICOS
Authors: Soares F.B. , Monteiro A.C.
Published: September 2020

RESUMO A associação de agentes biológicos e químicos pode ser uma estratégia promissora para o controle de insetos e ácaros, visando a aumentar a eficiência, reduzir custos e impactos ambientais. Este trabalho objetivou avaliar a compatibilidade do fungo Metarhizium anisopliae (Metsch.) Sorokin com carrapaticidas químicos atualmente usados no controle de Riphicephalus (Boophilus. microplus (Canestrini). O fungo foi cultivado em meio contendo 40, 55, 70, 85 e 100% da dose recomendada (DR) de carrapaticidas comerciais contendo vários princípios ativos, formulados em diferentes composições. Avaliou-se o crescimento vegetativo, a esporulação e a viabilidade do fungo e fez-se a classificação toxicológica dos acaricidas. Os carrapaticidas contendo clorfenvinfós + diclorvós (Amiphós®), cipermetrina + clorpirifós + citronelal (Barrage®) e amitraz + clorpirifós (Carbeson®) foram classificados como tóxicos, pois inibiram o crescimento e a esporulação, e apenas o último não afetou a viabilidade do fungo. O carrapaticida contendo cipermetrina (Colosso®) foi classificado como compatível e moderadamente compatível nas doses de 40 e 65% da DR, respectivamente, e aquele contendo spinosad (Elector®) foi o que menos afetou os parâmetros avaliados, sendo moderadamente compatível nas doses de 55 a 100% da DR e compatível na dose de 40% da DR. A maioria dos carrapaticidas químicos avaliados não foi compatível com o fungo M. anisopliae; apenas aqueles formulados com cipermetrina e com spinosad mostraram alguma compatibilidade para serem empregados em uma possível estratégia de uso associado.
Influence of ibuprofen-arginine on the concentration of amoxicillin in the plasma and tissues of rats with induced periapical lesion
Authors: MACKEIVICZ Giselle Ariana Otto , CASTRO Fernanda Fontoura de , ROSSI Júlia Maria de , ESMERINO Luis Antônio , SANTOS Fábio André , POCHAPSKI Márcia Thaís
Published: September 2020

ABSTRACT Objective The aim of this study was to evaluate the influence of ibuprofen-arginine on the concentration of amoxycillin in the plasma and periapical tissues of rats with induced apical periodontitis. Methods Twenty-eight Wistar rats were divided into the following four groups: PL: placebo (saline); AM: amoxycillin (100 mg/kg); IB: ibuprofen-arginine (100 mg/kg); and AM+IB: amoxycillin (100 mg/kg) + ibuprofen-arginine (100 mg/kg). The animals were submitted to pulp exposure in the first lower left molar, which remained open for fifteen days; this was then closed with composite resin and remained for a further seven days. The treatments were performed using a single dose of the medication (gavage) one hour before taking the samples. Two mL of blood was collected from the aorta to obtain the blood plasma and the periapical tissue samples, which were homogenized to obtain the supernatant. The samples (plasma and the supernatant periapical tissue) were used to obtain the antibiogram for the analysis of the levels of amoxycillin in the plasma and periapical tissues. Results The amoxycillin concentration was higher in the AM group compared to the other groups (p < 0.05, ANOVA with Tukey’s test). Ibuprofen-arginine interfered with plasma concentration of amoxycillin; however, the AM+IB group had a higher concentration of amoxycillin than the PL and IB groups (p < 0.05, ANOVA with Tukey’s test). The analysis of the supernatant from the periapical tissues showed no significant difference between the groups (p > 0.05, Kruskal-Wallis test). Conclusion Ibuprofenarginine can interfere with the plasma concentration of amoxycillin but this study failed to show the effect of ibuprofen-arginine on the concentration of amoxycillin in the periapical tissues .