bluuebunny/crossref_metadata_2025 huggingface dataset:
Setting Standards of Care Quality!
Authors:   EURORDIS - Rare Diseases Europe, Dubief Jessie
Published: November 2024

This report presents the results of the H-CARE Pilot Survey for the four European Reference Networks (ERNs) that initated this study conducted by Rare Barometer: ERN GENTURIS, ERKNet, ERN Lung and eUROGEN.

The goal of this study was to test the feasibility of measuring rare disease patients’ and carers’ experience with the care delivered by healthcare providers who are part of an ERN. A Topic Expert Committee composed of patient representatives, clinicians and managers from ERNs GENTURIS, ERKNet, Lung and eUROGEN selected a patient reported Experience Measure (PREM) questionnaire validated for chronic conditions, the Patient Assessment of Care for Chronic Conditions Short Form (PACIC-S). This questionnaire was administered by Rare Barometer, with the participation of hospital units that were members of the four ERNs of the pilot.

This report presents the results of the pilot study for the 1,319 patients and carers who assessed European healthcare providers treating rare diseases affecting kidneys, lungs, the urogenital area and genetic tumour risk syndromes:

Patients had a better healthcare experience when they were treated by hospital units that are part of a ERN.
The PACIC-S showed good internal consistency and good construct validity in German, French, English and Spanish. But content validity was low as all aspects of care experience for rare diseases were not covered by the scale, showing that the PACIC-S did not fully capture the healthcare experience of people living with a rare disease.
Recommendations for the development and validation of a new scale for RDs include planning onsite distribution of paper questionnaires in specialised hospital units, in addition to online distribution towards patient organisations and on social media, in order to reach a sufficient number of respondents for each ERN and language.
MANUSIA BERDOSA: Kajian Hermeneutik Pengkhotbah 7:1-22 dan Implikasinya bagi Pemuda GMIM Musafir Kleak
Authors: Robot Kevin Yeremia
Published: November 2024

Artikel ini bertujuan menyajikan tulisan tentang hasil penafsiran Pengkhotbah 7:1-22 dan menghubungkan dengan pemuda GMIM Musafir Kleak. Teks ini memberi gambaran mengenai kehidupan manusia yang tidak luput dari dosa jika dikaitkan dengan kehidupan pemuda maka masalah hidup pemuda tidak terlepas pada perilaku negatif yang dalam pemahaman teologis disebut dosa. Hal-hal yang berkaitan dengan dosa seperti melibatkan kebiasaan merokok, alkohol, seks bebas, dunia malam dan lain-lain. Pendekatan yang digunakan adalah pendekatan kualitatif serta menggunakan metode hermeneutik kritik historis untuk mendapat makna asli dan historis dari teks tersebut. Teks ini menjelaskan tentang semua manusia yang berdosa dan nasihat untuk hidup sewajarnya serta hidup berhikmat. Implikasi melalui teks ini, para pemuda tidak seharusnya saling menghakimi dan saling membentuk kelompok yang eksklusif dalam komunitas pemuda tetapi sebagai bagian dalam pelayanan gereja maka perlu membangun satu kebersamaan yang saling menguatkan.
Madiara dalam Perspektif Jemaat GMIM Haleluya Kayuuwi Wilayah Kawangkoan Dua
Authors: Rumondor Solideo Timotius , Mawuntu Marhaeni Luciana
Published: November 2024

Artikel ini membahas mengenai Madiara dalam Perspektif Jemaat GMIM Haleluya Kayuuwi. Metodologi penelitian yang digunakan adalah metode kualitatif yang dijabarkan secara deskriptif. Metode penelitian deskriptif adalah metode yang dilakukan untuk mengetahui gambaran, keadaan, suatu hal dengan cara mendeskripsikannya sedetail mungkin berdasarkan fakta yang ada. Dahulu Sebagian besar masyarakat desa kayuuwi banyak yang sangat mempercayai hal-hal yang berkaitan dengan ritus, sehingga jika ada warga yang mati mendadak, sakit berkepanjangan ataupun menghilang di perkebunan maka masyarakat percaya orang tersebut di guna-guna, hal tersebut didasari rasa benci iri dengki kepada orang tersebut. Artikel ini ingin memeriksa perspektif dari setiap anggota jemaat tentang pemahaman mereka mengenai Madiara dan kaitannya dengan kehidupan bergereja.
Kajian Etis Teologis Peran Pelayan Khusus Terhadap Orang Dengan Gangguan Kejiwaan di Jemaat GMIM Getsemani Lansot Wilayah Tomohon III
Authors: Sritenaya Mikha Oktaviani , Palempung Rivay B.
Published: November 2024

Artikel ini bertujuan untuk mengkaji secara etis-teologis Peran Pelayan Khusus terhadap Orang Dengan Gangguan Kejiwaan di Jemaat GMIM Getsemani Lansot. Dalam konteks ini, pendekatan etis-teologis digunakan untuk memahami bagaimana peran pelayan khusus dalam menghadapi dan membantu individu dengan gangguan kejiwaan, sesuai dengan prinsip-prinsip moral dan nilai-nilai spiritual yang mendasari ajaran agama. Penelitian ini menggunakan metode kualitatif. Hasil penelitian menunjukkan bahwa peran pelayan khusus terhadap Orang dengan gangguan kejiwaan di Jemaat GMIM Getsemani Lansot sangat penting dan beragam. Mereka tidak hanya memberikan dukungan secara emosional dan spiritual, tetapi juga memberikan bimbingan dan pelayanan praktis sesuai dengan kebutuhan individu. Penelitian ini juga mengidentifikasi beberapa tantangan dalam peran pelayan khusus, termasuk stigma dalam masyarakat terhadap gangguan jiwa, kurangnya pengetahuan tentang orang dengan gangguan jiwa, serta keterbatasan sumber daya yang tersedia. Oleh karena itu, disarankan agar pendekatan yang holistik dan terpadu dalam pelayanan orang dengan gangguan kejiwaan terus dikembangkan, dengan melibatkan setiap komponen dalam pelayanan gereja, lembaga kesehatan mental, dan pihak yang terkait.
Kajian Etis Teologis Tentang Penggunaan Alkitab Elektronik dalam Ibadah oleh Kateogrial Pria Kaum Bapa di Jemaat GMIM Eklesia Makawidey Wilayah Bitung II
Authors: Tempo Yulia Virginia , Tamaweol Roy Decky
Published: November 2024

Tujuan dalam penulisan karya ilmiah ini adalah untuk menganalisa mengenai kajian etis terhadap peribadatan Jemaat GMIM Eklesia Makawidey terlebih khusus kategorial Pria Kaum Bapa yang jarang membawa Alkitab dalam ibadah. Metode yang di gunakan dalam penelitian ini yaitu metode penelitian kualitatif dengan metode observasi dan wawancara serta studi pustaka untuk melengkapi kebutuhan teoritis dalam mengkaji permasalahan ini. Penulisan karya ilmiah ini ingin melihat salah satu masalah dalam gereja dan berniat untuk memberikan sumbangsih terhadap masalah yang muncul ini. Pria kaum bapa adalah seorang kepala keluarga dalam kehidupan keluarga yang harus membimbing dan membina kehidupan keluarga dalam pertumbuhan iman yang sessungguhnya.
نحو مقاربة تخاطبية في دراسة الصرف وتدريسه لوارثي اللغة العربية
Authors: علي محمد محمد يونس
Published: November 2024

يقترح هذا البحث مُقارَبةً تخاطبيةً لتدريس الصرف العربي المصمَّم لوارِثي اللغة، فإدراكًا للصعوبات التي يُواجهها هؤلاء المتعلِّمون في تحقيق الطلاقة اللغوية؛ يوفِّر هذا النهج إطارًا شاملاً لبناء الكلمات العربية باستعمال التحليل الدلالي والتخاطبي، ومن خلال الخوض في البنية الداخلية وآليات تكوين الكلمات، بما في ذلك الإلصاق، والصياغة الاشتقاقية، والضمُّ؛ تُمكِّن هذه الطريقة المتعلِّمين من كشفِ العلاقة المعقَّدة بين المبنى والمعنى، ومن خلال التركيز على استعمال اللغة في السياق التخاطبي؛ يمكن تعميق فهمِهِم صَرْفَ اللغة العربية بدراسة كيفية ربطِ العناصر الصرفية بمعاني الكلمات ووظائفها، وإذا ما تمكَّنا من تعزيز الفهم الواعي للقواعد والمبادئ الصرفية؛ أمكن لوارِثي اللغة توليدُ مجموعة واسعة من الكلمات البسيطة والمركبة، وتعزيز فهمِهِم الصرف الدلالي، وتسهيل اكتساب اللغة، وتعزيز مهارات الاتصال، وهذا يعزِّز تطوُّرهم اللغوي وثِقَتَهُم في مخاطباتهم، ويتوَّج البحث باقتراح تطبيقات عملية للفصول الدراسية، والدعوة إلى موادَّ تعليمية مخصَّصة تُلبِّي الاحتياجات الفريدة لوارِثي اللغة، ويسعى هذا المسلك إلى تعزيز النموِّ اللغوي لهؤلاء الطلبة، مما يُسهم في الحفاظ على اللغة والثقافة العربية والنهوض بهما.
Understanding Emissions from the Thermal Treatment of Intermediate Level Radioactive Waste
Authors:   , Stone Alex
Published: November 2024

Practical applications of vitrification and usage of glass matrices has highlighted the importance of understanding these materials to a higher standard. This includes prioritising closing gaps in the past research to make the process safer and more effective for the future. One of the clear areas is the loss of radioactive/volatile components of waste upon heat treatment or vitrification. It is widely known that caesium, iodine and chlorine are all lost to some degree through volatilisation mechanisms at elevated temperatures and therefore understanding the extent of these processes is key to maintaining a total inventory of radioactive material on nuclear licenced sites. During this study we have found that iodine loaded into glass compositions: Mixture Windscale (MW), calcium-zinc (CaZn) and a silica-free version of CaZn, is the most volatile (100% loss at 1200 °C) of the three elements investigated, however, all lost mass upon heat treatment. The volatilisation can be reduced for iodine and caesium by introducing common wastes to the system. Clinoptilolite and Corroded Magnox Sludge (CMS) were studied and the loss of atomic caesium was found to show a 15-21 wt% improvement in retention in both MW and CaZn glass when loaded with up to 30 wt% clinoptilolite, the effect being less pronounced for CMS. Iodine retention also improved, a maximum of 16 - 33 wt% iodine was found in base glasses upon 40 wt% clinoptilolite, CMS again having less of an effect on the retention at the same waste loading (4.5 wt%), theorised to be due to the binding of caesium or iodine to the waste before melting. Atmospheric changes were investigated changing from air to nitrogen which had a positive effect on retention of caesium (+ 8 wt%) and significantly so for iodine (+74 wt%). This is a demonstration of the importance of oxygen in these systems, the two sources of oxygen are from the glass frit/waste and from the atmosphere with the atmospheric oxygen being readily available and able to react before the glass frit melts increasing the proportion of gaseous iodine and to some extent caesium.
Design, Preparation and Characterisation of Polyurethane Nanocomposites Membranes for Apparel Applications
Authors:   , Chadwick Rebecca
Published: November 2024

Breathable waterproof membranes protect the wearer from the climate and potential hazards. The membrane must be waterproof yet breathable to maintain comfort to the wearer. Previously the inclusion of layered silicates and graphene oxide (GO) have been shown to improve mechanical properties of polyurethane (PU) however, limited studies have been conducted on montmorillonite (MMT) and GO's impact on breathability, waterproofness and microporosity of PU membranes. This research project in conjunction with a sponsoring company, PIL Membranes LTD, aims to fill that void in knowledge. The effects of MMT and GO on both monolithic and microporous PU membranes for applications in outdoor wear will be investigated. Specific interest, due to the nature of the membrane's application, will focus on the nanofillers effect on mechanical properties (storage modulus & Young's modulus), surface roughness, wettability, breathability, and waterproofness. The MMT nanofiller C20 dispersed well in both monolithic and microporous PU membranes, often providing modest improvements to a range of properties including, breathability, surface roughness and static dissipative.
Les ambivalences maladives de Phaedra’s Love
Authors: Gaumond Pierre-Olivier
Published: November 2024

Dans cet article, il s’agira d’explorer l’imaginaire médical au sein de la pièce de théâtre Phaedra’s Love (1996) de la dramaturge britannique contemporaine Sarah Kane. Alors qu’il y a parfois mention de la place des médecins dans sa dramaturgie – particulièrement dans Cleansed (1997) et 4.48 Psychosis (2000) –, cette réflexion n’a que trop rarement été envisagée dans le cadre de Phaedra’s Love, où le personnage principal, l’oiseux et misanthrope prince Hippolyte, apparaît dans l’ambivalence, faisant office à la fois de malade, de maladie… et de remède.
Quand la surexposition de l’intime irradie le processus de création théâtral : Krystian Lupa et les jeunes metteurs en scène polonais issus de sa transmission
Authors: Pierrot Rébecca
Published: November 2024

L’observation du processus de création de l’un des maîtres de la mise en scène européenne, Krystian Lupa, et de ceux de nombre de jeunes metteurs en scène polonais qui se réclament de sa transmission, comme Krzysztof Warlikowski, Michał Borczuch, Łukasz Twarkowski ou Oskar Sadowski, met au jour un phénomène commun mais néanmoins singulier que l’on pourrait qualifier de « surexposition de l’intime ». Ce phénomène intervient dès le début du processus de création commune, soit lors de la rencontre de l’équipe artistique en salle de répétition, et perdure jusqu’à la scène, marquant l’oeuvre tant dans le fond que dans la forme.
"Shared and Collective Stress"
Authors: Seida Kimberly , Desmeules-Trudel Félix , Jakubiec Brittany A.E.
Published: November 2024

The confluence of increased demand for mental health services and decreased resources due to the COVID-19 pandemic has created multiple challenges for mental healthcare and social service providers. 2SLGBTQI service providers may be disproportionately impacted by pandemic-related challenges, such as psychological distress, vicarious traumatization, and burnout. However, there are significant knowledge gaps regarding the needs and experiences of 2SLGBTQI and allied service providers in the context of the COVID-19 pandemic in Canada. To address these gaps, we conducted a national survey (N = 304), eight semi-structured focus groups, and five semi-structured interviews (N = 61) with 2SLGBTQI care seekers and service providers across Canada. Based on data from the 106 2SLGBTQI service providers and 3 allied service providers who took part in these research activities, this paper explores the challenges service providers encounter when providing care to 2SLGBTQI individuals as well as their adaptive responses to these challenges. Understanding the experiences of service providers who share lived experiences of discrimination and marginalization with their clients is critical to addressing barriers to affirming mental healthcare, shifting services to meet the evolving needs of both care seekers and providers, and developing upstream, comprehensive solutions to address the causes of 2SLGBTQI mental health disparities.
Taking Back Curriculum
Authors: Moorhouse Emily
Published: November 2024

This paper maps key factors that activate adult stakeholders in Ontario to support curriculum pertaining to consent and non-violence in K-12 education. The paper draws from a study that used three qualitative approaches: (1) the design of an original media literacy curriculum module for Ontario youth ages 13-15; (2) curriculum assessment of the module by diverse stakeholders in Ontario K-12 education (n=20); and (3) analysis of archival documents pertaining to consent education and media literacy in Ontario, including official curriculum and media reports. Four key factors united stakeholders in supporting K-12 curriculum pertaining to consent and non-violence in Ontario. Firstly, stakeholders are intrigued by media-based pedagogies that can facilitate consent education that is “culturally relevant” (Ladson-Billings 1994; 1995) for diverse learners in Ontario. Stakeholders are also more likely to support consent and violence prevention initiatives if accompanied by professional development and teaching tools. Educator collectives and political organizing also allow for more feminist and social-justice pedagogies in the classroom, including consent education. Finally, parent councils and community groups are essential places for activism and knowledge sharing that can meet the needs of community members, while addressing stakeholders’ attitudes and behaviours that gatekeep violence prevention initiatives in education.
Body Modification as Body Art
Authors: Cameron Jessica
Published: November 2024

In this article, I discuss my “anti-aging” body modification practices as body art. The art documents my bodybuilding programs, self-administered neurotoxin (Botox) injections, and skin resurfacing treatments. Susan Pickard (2020) argues that femininity and aging are associated with the abject. She maps the abject and non-abject onto Simone de Beauvoir’s distinction between immanence and transcendence. Because “abjection should always be understood as an element of [...] oppression” (Pickard 2020, 159), my art practice could be read as an anti-feminist, ageist attempt to expel the abject. After offering a counter-argument that positions my practice as feminist, I use Kathy Acker’s (1993) writing on bodybuilding to offer a third reading. Muscles grow when they are worked until failure. This practice of constantly coming up against the body’s limits is a rehearsal for the ultimate failure of the body: death (Acker 1993). If thanatology is the study of death and dying, bodybuilding is autothanatology. My “anti-aging” interventions are similar; they are inevitable failures that cannot stop the aging process. In this way, my practice is a reminder that the body exists in a state of immanence, even while I may attempt to frame my immanence along transcendental terms.
The Feminist XResistance Project
Authors: Ariel Galit , Bhandari Aparajita , York-Bertram Sarah , Hopkins Kacie G.
Published: November 2024

On May 31, 2023, we showcased the Feminist XResistance project at the Women and Gender Studies et Recherches Féministes (WGSRF) conference under the apt thematic “Take Back the Future.” The project started on July 9, 2022, when a group of international, interdisciplinary, early career feminist scholars convened on Zoom for the Feminist Digital Methods (FDM) Drop-in Virtual Lab hosted by York University’s Centre for Feminist Research (CFR). The drop-in took place two weeks after the United States Supreme Court overturned the constitutional right to an abortion and became a digital space to express our fears and anger over rising gender essentialist fascism, worries about the future, and to imagine feminist digital methods for resistance. In this reflection and commentary, we share our observations and processes for the Feminist XResistance project, starting with our first exploratory workshop, our co-creative analysis and outputs, the development of our AR installation, and, finally, our conclusions and insights.
One Rule to Rule Them All: Subordinate Legislation and the Law of Judicial Review
Authors: Mancini Mark P.
Published: November 2024

The Supreme Court’s decision in Vavilov purported to provide a complete rule regime for the review of administrative action, simplifying an area of the law subject to erratic doctrinal amendment. One question, post-Vavilov, is how far this rule regime sweeps.

For some time, Canadian courts have struggled to review subordinate legislation — executive regulations, municipal bylaws, and other binding rules. At some points, courts have suggested that this sort of legislation should be reviewed highly deferentially such that only a regulation completely unrelated to an enabling statute would be ultra vires. At other times, courts have simply applied the run-of-the-mill reasonableness standard, which governs adjudicative decisions, to municipal bylaws and other binding rules. This confusion has only proliferated after the Supreme Court’s rejigging of the law of judicial review in Vavilov, and courts have since struggled to determine whether Vavilov, which sets a presumptive standard of reasonableness for all administrative action, applies to subordinate legislation.

This paper argues that Vavilov’s rule regime, whatever its flaws, provides a set of constitutionally compliant rules that are workable in the context of subordinate legislation, including executive legislation. It argues that Vavilov’s simplifying mission should be construed broadly. By centring the institutional design choices of legislatures, Vavilov connects to the legitimate constitutional source of subordinate legislation: its attachment to a statute adopted in the primary lawmaking act. This core feature of Vavilov makes it transferable, if imperfectly, to the context of subordinate legislation. It also makes Vavilov an attractive starting point for other areas of the law of judicial review.
Risk’s Relations: Dangerous Offender Decisions, Risk Assessment Tools, and State Accountability for Colonial Oppression
Authors: Nussbaum Sarah-jane
Published: November 2024

Sentencing law reveals a tension between judges acknowledging connections between colonialism, criminalization, and imprisonment and using individual sanctions, alone, to address what they identify as the social and institutional dimensions of conflict and harm. This article illuminates the limits of individualized sentencing as a response to colonial oppression by looking closely at judicial engagement with risk assessment tools in the context of “dangerous offender” proceedings. Judges are making progress by holding the state accountable for ensuring that risk assessment tools accurately predict an Indigenous offender’s likelihood of being charged or convicted in the future and for implementing programs in prisons that provide Indigenous offenders with opportunities to change their risk scores. Judges are also acknowledging a well-established critique of these tools—the fact that they measure people’s experiences of oppression for which the state ultimately bears at least some accountability. Unfortunately, even when judges acknowledge that risk is at least partially constructed and maintained by relations of power, there is no concrete outcome available to address such an acknowledgment. The dangerous offender regime requires judges to prioritize public protection through individual sanctions, alone. This analysis leads the author to suggest that some form of authority for sentencing judges to directly assess state accountability for conflict, harm, and their prevention might give rise to decisions that more clearly and fittingly identify how safety can be facilitated by not only individuals but also the state.
S’Albufereta de Pollença (Mallorca): una introducció a la seva geomorfologia i l’evolució sedimentària recent
Authors: Fornós Joan J. , GÓMEZ-PUJOL Lluís , Cau-Ontiveros Miguel A. , Mas-Florit Catalina
Published: November 2024

S’Albufereta de Pollença es troba situada al nord de l’illa de Mallorca, a l’extrem més meridional de la badia de Pollença. Es tracta d’una zona humida, amb una extensió de 400 ha que estructuralment ocupa una depressió postmiocena resultat de l’extensió distensiva, que tingué lloc després de la formació de la serra de Tramuntana a finals de l’oligocè-miocè inferior. Una campanya de sondeigs mecànics, juntament amb les tasques de cartografia geomorfològica, permeten fer una descripció dels elements morfològics i dels diferents subambients sedimentaris presents al registre holocènic i avançar una evolució sedimentària de la zona. S’Albufereta consisteix en una zona d’estanys i d’aiguamolls solcats per una sèrie de canals, separats de la mar per una restinga arenosa, que actualment connecta amb una única gola amb el mar i que en alguns sectors presenta indicis de recessió. En referència amb el rebliment sedimentari més recent, l’holocènic, no adquireix una potència destacable, de 3 a 5 m de potència, descansant sobre el basament juràssic o les margues del miocè. Hi predominen les fàcies llimoses detrítiques, parcialment arenoses i amb aportacions puntuals de graves, de coloracions rogenques; la qual cosa indica que el rebliment de l’àrea es deu principalment a les aportacions al·luvials associades als torrents. La naturalesa i la potència del registre indica que la transgressió holocena no sembla que hagi superat el metre d’altura respecte al nivell actual de la mar i que, en aquesta àrea, la subsidència no sigui molt important. Tot apunta que durant la transgressió holocena es reomple la paleotopografia heretada del darrer període glacial.
Avaluació qualitativa del paisatge oleícola del Maestrat (País Valencià)
Authors: Membrado-Tena Joan Carles , Hermosilla-Pla Jorge
Published: November 2024

Aquest article estudia i avalua qualitativament el paisatge del sistema agrícola de les oliveres del Maestrat (País Valencià) mitjançant un mètode qualitatiu basat en el projecte SAMUTER (Sistemes Agroalimentaris Multifuncionals Territorialitzats), que estudia i descriu sistemes agrícoles alternatius al model agroindustrial imperant actualment a escala mundial. Els resultats mostren que el sistema oleícola del Maestrat coincideix amb la major part dels criteris que defineixen un SAMUTER, sobretot pel que fa a la preservació del paisatge. Per contra, quant a la producció alimentària, l’olivar del Maestrat no entra dins dels paràmetres dels SAMUTER. Determinades condicions mediambientals (sòl i clima) i una elevada edat mitjana dels llauradors propicien una producció de baixa qualitat, que sobreviu només gràcies al sistema cooperativista i a les ajudes de la PAC (Política Agrícola Comuna). Només un petit nombre d’oleïcultors maestratencs produeix un oli d’alta qualitat que compleix amb els criteris dels SAMUTER.
El curso medio del río Ebro: bases preliminares para su diagnóstico hidromorfológico y perspectivas de gestión y restauración
Authors: Ollero Alfredo , Ibisate Askoa , Ferrer-Boix Carles , Martín Vide Juan Pedro , Ballarín Daniel , Castillo Pascual Pepa , García Lagranja Juan Miguel , García-Rodríguez Saiosa , Melián Álvaro , Nuñez-González Francisco , Ormaetxea Orbange , Noemí Pirchi Valeria , Sáenz de Olazagoitia Ana , Sánchez Fabre Miguel
Published: November 2024

El Ebro medio de cauce libre es un tramo excepcional a escala peninsular por sus dimensiones, con un funcionamiento complejo y singular, así como representativo en cuanto que gran río mediterráneo. Este trabajo constituye una reflexión general que se sitúa en el punto de inflexión entre lo que ya se conoce del Ebro medio por análisis anteriores y lo que se está estudiando en el marco del proyecto SEDEXCHARE. Se realiza un diagnóstico hidromorfológico básico en el que se pretende profundizar en cuatro tramos de estudio de detalle y se presentan las principales carencias actuales de conocimiento que dificultan el planteamiento de un nuevo sistema de gestión fluvial y de riesgos. Se estima que la devolución de espacio al río, para que este pueda contar de nuevo con un cauce activo y un corredor ribereño ancho y continuo, dotará de resiliencia natural, social y territorial a un espacio fluvial que debería ser protegido y conservado, venciendo también así las inercias y conflictos socioambientales que ahora obstaculizan el proceso de restauración.
Fonts per a la reconstrucció dels sistemes tradicionals de reg amb aigües d’avinguda en rambles del sud-est peninsular
Authors: Marco Molina Juan Antonio , Giménez Font Pablo
Published: November 2024

Les rambles mediterrànies, especialment al sud-est de la península ibèrica, han tingut un aprofitament històric consistent en la utilització de les aigües d’avinguda, que han estat desviades per a aportar regs extraordinaris als camps de cultiu. Es tracta de sistemes pluriseculars, en el present desmantellats o abandonats, que tingueren unes conseqüències hidrogeomorfològiques molt importants. Tot i això, la seua dimensió espacial encara no està ben calibrada i calen més estudis de cas, aplicant una metodologia compartida. En el present article es reflexiona sobre la disponibilitat i el valor de fonts documentals de diferent signe (documentació històrica escrita, memòria oral, cartografia, fotografia aèria i treball de camp), prenent com a cas d’estudi principal el de la Rambla de la Sarsa-El Derramador (Agost, Alacant). Les conclusions demostren com, si bé a escala desagregada, cada font aporta una informació relativament pobra, és en la consideració de conjunt quan s’obtenen els resultats més significatius.
Farmacovigilância: da teoria à prática
Authors: Rossi Varalho Fabiana , de Carvalho Mastroianni Patrícia
Published: November 2024

Este livro analisa questões relacionadas à farmacovigilância num contexto histórico – traça um panorama acerca do assunto que abrange da antiguidade ao Brasil atual, abordando facetas como reações adversas a medicamentos, erros de prescrição, desvios de qualidade e suspeitas de inefetividade de medicamentos. Além de análises, a obra traz propostas para a implantação de um serviço diferenciado de farmacovigilância. A ideia de que tratamentos médicos possuem reações adversas que devem ser evitadas, mostra o livro, vem de longo tempo. Na Antiguidade, o Código de Hammurabi, conjunto de leis escritas da Babilônia, de 2.200 a.C., já previa punição ao médico causasse a morte de um paciente – ele teria as mãos amputadas. Já Hipócrates (460-370 a.C.), considerado o “pai da medicina” postulava: “primeiramente não causar danos”. E o médico e filósofo Galeno (131-201) advertia contra os perigos das prescrições mal-escritas e obscuras. De acordo com a pesquisa, teria sido feito na Grã-Bretanha o primeiro registro de Reação Adversa a Medicamentos (RAM), em 1848. Desde essa época, a vigilância e a fiscalização sobre esses produtos têm se tornado cada vez mais intensas em todo o mundo, inclusive com forte atuação da Organização Mundial da Saúde. No Brasil, legislação relacionada às reações adversas a medicamentos existe desde a década de 1970. A primeira data de 1976 e, entre outras providências, submete à vigilância sanitária medicamentos, drogas, insumos farmacêuticos e correlatos, assim como cosméticos e saneantes, entre alguns outros produtos. Hoje, o governo brasileiro exige que os detentores de registro de medicamentos gerenciem os riscos dos produtos.
Enhanced related-key differential neural distinguishers for SIMON and SIMECK block ciphers
Authors: Wang Gao , Wang Gaoli
Published: November 2024

At CRYPTO 2019, Gohr pioneered the application of deep learning to differential cryptanalysis and successfully attacked the 11-round NSA block cipher Speck32/64 with a 7-round and an 8-round single-key differential neural distinguisher. Subsequently, Lu et al. (DOI 10.1093/comjnl/bxac195) presented the improved related-key differential neural distinguishers against the SIMON and SIMECK. Following this work, we provide a framework to construct the enhanced related-key differential neural distinguisher for SIMON and SIMECK. In order to select input differences efficiently, we introduce a method that leverages weighted bias scores to approximate the suitability of various input differences. Building on the principles of the basic related-key differential neural distinguisher, we further propose an improved scheme to construct the enhanced related-key differential neural distinguisher by utilizing two input differences, and obtain superior accuracy than Lu et al. for both SIMON and SIMECK. Specifically, our meticulous selection of input differences yields significant accuracy improvements of 3% and 1.9% for the 12-round and 13-round basic related-key differential neural distinguishers of SIMON32/64. Moreover, our enhanced related-key differential neural distinguishers surpass the basic related-key differential neural distinguishers. For 13-round SIMON32/64, 13-round SIMON48/96, and 14-round SIMON64/128, the accuracy of their related-key differential neural distinguishers increases from 0.545, 0.650, and 0.580 to 0.567, 0.696, and 0.618, respectively. For 15-round SIMECK32/64, 19-round SIMECK48/96, and 22-round SIMECK64/128, the accuracy of their neural distinguishers is improved from 0.547, 0.516, and 0.519 to 0.568, 0.523, and 0.526, respectively.
Method selection affects the estimates of residency and site fidelity in bottlenose dolphins: testing sensitivity and performance of different methods using mark-resight data
Authors: Huesca-Domínguez Israel , Morteo Eduardo , Abarca-Arenas Luis Gerardo , Balmer Brian C. , Cox Tara M. , Delfín-Alfonso Christian A. , Hernández-Candelario Isabel C.
Published: November 2024

Residency (R) and site fidelity (SF) are important parameters in population ecology, yet their quantification poses challenges in marine mammals. Based on a previous review, this study used simulated and empirical mark-resight data to assess the variations and performance of the most used R (n = 8) and SF (n = 11) indices in peer-reviewed literature under different scenarios. We applied the Jolly-Seber model to simulate thousands of bottlenose dolphin populations varying resighting (p) and survival (Phi) probabilities, and performed calibration, sensitivity, and validation analyses. Our results underscore the effects of p and Phi on individual categorization within the diverse simulated conditions, representing the often-overlooked heterogeneity in residency classification for Tursiops populations. All SF indices showed similar and consistent performance (>0.70 Gower’s distance) across the simulated scenarios, even when compared to field study data from wild dolphin populations (i.e., Savannah, USA, and Alvarado, Mexico); thus, SF should be a critical parameter for interstudy comparisons. Conversely, R indices were remarkably different based on their definitions and classification criteria. The different thresholds among definitions largely biased the proportion of residents and transient individuals (or occasional visitors) even leading to counterintuitive outcomes. This emphasizes the importance of considering trade-offs in R index selection aligned with project goals, specific sampling efforts, and population dynamics. For instance, the simplified binomial categorization of R defined by Conway (2017) (https://digitalcommons.coastal.edu/etd/10/) easier to interpret but R indices incorporating temporal components (e.g., monthly, seasonal, and annual) outperformed (>0.70 Gower’s distance) other R indices lacking such criteria. This allowed for a more detailed representation of the temporal structure of the population, and higher consistency and accuracy while classifying individuals. Also, although the residency categories proposed by Möller, Allen & Harcourt (2002) (DOI 10.1071/AM02011) did not perform as well, these seemed to fit better when dealing with data gaps across spatial and temporal scales. Our results contribute to the ongoing discussion on methodological implications for the interpretation of ecological patterns, facilitating a nuanced understanding of population dynamics, aiding scientists, and conservation agencies in making informed decisions for bottlenose dolphin populations worldwide.
Analysis of differential expression of hair follicle tissue transcriptome in Hetian sheep undergoing different periodic changes
Authors: Chen Xueyan , Sun SunShuang , Sulaiman Yiming
Published: November 2024

Background

This study provides new information on long non-coding RNA (lncRNA) and messenger RNA (mRNA) expression profiles in the hair follicles of Hetian sheep via the sequencing and analysis of the transcriptome of skin hair follicles during three periods of periodicity change. This is important for improving the quality of carpet wool, providing a preliminary basis for further research on the targeting relationship of these mRNAs and their target genes, and providing a scientific basis for marker-assisted selection of Hetian sheep.

Methods

The periodic variation of anagen (P I, May, n = 3), catagen (p II, October, n = 3), and telogen (p III, January, n = 3) of the skin hair follicle tissue of three Hetian sheep ewes were selected. Skin samples were collected from the right mid-side of each sampled sheep at three hair follicle developmental stages. The three sheep were used for each developmental stage as biological and technical replicates for transcriptome sequencing and analysis.

Results

The statistical power of this experimental design, calculated in RNASeqPower, was 0.92. Differential expression analysis revealed 81 lncRNAs that were differentially expressed (46 up-regulated and 35 down-regulated) and 129 mRNAs that were differentially expressed (46 up-regulated and 83 down-regulated) during the PI and PII periods. Between the PI and PIII periods, a total of 144 differentially expressed lncRNAs and 693 differentially expressed mRNAs were identified. Of these, 73 lncRNAs were significantly up-regulated and 71 were significantly down-regulated, while 474 mRNAs were significantly up-regulated and 219 were down-regulated. Additionally, a total of 87 lncRNAs were found to be differentially expressed, with 40 up-regulated and 47 down-regulated, along with 39 differentially expressed mRNAs (23 up-regulated and 16 down-regulated), between the PII and PIII stages. The functional assessment revealed that the mRNA expressed in the cells is related to the membrane, cell processes, metabolism, extracellular region, and other GO items. It is enriched in thyroid hormone synthesis, choline metabolism, cancer, AMPK, Hedgehog, and other signaling pathways.

Conclusion

A total of 2,286 lncRNAs (including 965 known and 1,321 novel lncRNAs) and 20,879 mRNAs were identified. These co-expressed differentially expressed genes could be used as candidate genes for studying the periodic changes of the hair follicles in Hetian sheep.
A Review on Biodegradable Films from Banana Peel
Authors: Shiam Md Azizul Hakim , Alam Asraful , Biswas Mrityunjoy , Alam Mahfujul , Misha Mohosina Hossain , Ahmed Shahabuddin , Hasan Mustafa Kamrul
Published: November 2024

The increasing environmental issues associated with plastic waste have sparked a heightened interest in the creation of biodegradable alternatives derived from renewable resources. One notable option is biodegradable film made from banana peels, which presents an environmentally friendly and sustainable solution. This review examines the viability of utilizing banana peels as a raw material for the production of biodegradable films. It investigates the chemical makeup of banana peels, emphasizing the presence of starch, cellulose, and pectin, which are essential for film formation. The review further addresses various processing techniques, including starch extraction, plasticization, and cross-linking, that improve the mechanical properties and biodegradability of the films. Moreover, it analyzes the environmental implications, potential applications in food packaging, and the challenges related to scalability and cost-effectiveness. The findings indicate that biodegradable films derived from banana peels represent a promising substitute for petroleum-based plastics; however, additional research is necessary to enhance their mechanical strength and commercial feasibility. The review concludes by advocating for ongoing investigation into natural waste resources for the development of sustainable materials.
Economic Assessment of Soybean Production in Amravati District: Costs, Returns, and Farm Size Dynamics
Authors: Joharapurkar S. M. , Thakare S. S. , Ingle S. N.
Published: November 2024

The research estimated the cost and returns of soybean production in the Amravati district of Maharashtra, a key region for soybean cultivation in India. Primary data was collected from 120 farmers across different farm sizes (small, medium, and large) through personal interviews and structured questionnaires. The study assessed the economic dynamics of soybean farming by examining inputs such as human labour, bullock labour, seeds, fertilizers, mechanization, and plant protection costs, and analyzed the output in terms of yields and profitability. The findings revealed significant variations in resource allocation and profitability across farm sizes. Small farmers incurred higher costs, particularly in labour due to limited mechanization, compared to medium and large farmers. The per quintal cost of production for overall farmers was Rs. 4002.20. In contrast, large farms benefited from economies of scale, with lower production cost (Cost C3: Rs. 60,878.89/ha) compared to small (Rs. 62,755.14/ha) and medium farms (Rs. 63,009.94/ha). Medium-sized farmers emerged as the most profitable, showing the best balance between input costs and returns, with a gross return of Rs. 72,597.99/ha. The overall input-output ratio for soybean cultivation indicates profitability, with a ratio of 1.14 at Cost C3. The study emphasized the potential for improving efficiency in farms through strategic investments in mechanization and better resource management. By enhancing productivity, such measures can help bridge the gap between local and global soybean productivity levels and give economic stability to soybean farmers in the region.
Confession of a Shopaholic: The Purchase Decision Behavior of Generation Z
Authors: Haeruddin Muhammad Ilham Wardhana
Published: November 2024

Aims: This study aims to determine, both simultaneously and partially, the effect of Influencer Marketing (IM) and Social Media Marketing (SMM) on Purchasing Decisions (PD) on Uniqlo fashion products.
Study Design: This type of research is descriptive quantitative research which aims to examine the relationship between the independent variable and the dependent variable.
Place and Duration of Study: State University of Makassar, from June to September 2024.
Methodology: The population in this study were students who used Uniqlo products at the State University of Makassar. The sampling technique in this study was non-random sampling and the type of sampling used was purposive sampling with the number of samples was 100 respondents. The data analysis method in this study consists of several tests consisting of Validity and Reliability Tests, Classical Assumption Tests, Multiple Linear Regression Analysis, and Hypothesis Tests, and uses SPSS in data processing.
Results: The study found a significant correlation between influencer marketing, social media marketing, and purchasing decisions. Based on the results of data analysis, it is known that the significance value of the Influencer Marketing on Purchase Decision is 0.016 <0.05 and the t value is 2.444> t table 1.98447. Furthermore, the Social Media Marketing has a t value of 8.976> t table 1.98447. The significance value for the effect of the Social Media Marketing on the Purchasing Decision is 0.000 <0.05 and the t value is 8.976> t table 1.98447. The F value of 129.644 is much greater than the F table of 3.09 (129.644 > 3.09) with a significance level of 0.000 less than 0.05 (0.000 < 0.05).
Conclusion: Based on the results of the study, it is known that both partially and simultaneously, Influencer Marketing and Social Media Marketing have a positive and significant influence on Purchasing Decisions.
Clonal Diversity and Spatial Dissemination of Drug-resistant Mycobacterium tuberculosis Complex among HIV Seropositive Patients in Southwest Nigeria
Authors: Oluwatosin Ojetayo Helen , Ugbomioko Daniel
Published: November 2024

Mycobacterium tuberculosis complex display relatively static genomes and 99.9% nucleotide sequence identity. Studying the evolutionary history of such monomorphic bacteria is a difficult and challenging task. Therefore, this study was undertaken to investigate the clonal diversity and spatial dissemination of drug-resistant M. tuberculosis complex among HIV seropositive clients in Southwest Nigeria. A total of two-hundred and seventeen (217) consented HIV positive (case subjects) and fifty (50) non-HIV positive controls were recruited for this study. Two Sputum samples were collected from each participant in two consecutive days. The samples were divided into two parts: one part was decontaminated using NAOH-NALC method and aseptically cultured for Mycobacteria on Lowenstein-Jensen (LJ) medium with and without pyruvate. Mycobacterial isolates were characterized using conventional and molecular methods. Anti-TB drug sensitivity test was done using 1% proportion conventional method on LJ.  MTBC isolates were sequenced using Genetic Analyzer 3130xl sequencer. Genetic relatedness and clonal diversity (phylogenetic analysis) of MTBC isolates were done using Bio- Edit software and MEGA 6. Out of 217 HIV positive participants, 105(48.4%) were male, while 112(51.6%) were female. Twenty-six (26(52.0%)) of the control subjects were male, while 24(48.0%) were females. The overall prevalence of TB among PLHIV was found to be 19.1%. The prevalence of NTM among PLHIV was found to be 2.8% with M. intracellulare being the predominant organism isolated.  Participants’ age was found to be significantly associated with TB (P<0.05), however there was no significant association between TB and sex of the participants (P<0.05).  The prevalence of culture confirmed drug-resistant TB (DR-TB) among PLHIV was found to be 11.9%, with Rifampicin having the highest monoresistance rate of 5.5%. The overall prevalence of MDR-TB among PLHIV was found to be 9.2%. The phylogenetic analysis of M. tuberculosis strains revealed same clone of all isolates. All PLHIV should be screened for drug-resistant TB especially MDR-TB as the prevalence of primary MDR-TB is high among them. Further study like 3R gene-based studies of adaptation and evolution is needed to facilitate further epidemiological studies of these bacteria.
Cytokines Levels and Anti-tuberculosis Drug Resistance among HIV Seropositive Patients in Ibadan, Southwest, Nigeria
Authors: Oluwatosin Ojetayo Helen , Ugbomioko Daniel
Published: November 2024

Susceptibility to TB disease rises on mutations in cytokine receptors which ultimately lead to defective signaling and alter the immune surveillance and bacterial killing. Therefore, this study was undertaken to investigate the association between cytokines and anti-TB drug resistances. A total of 217 people living with human immunodeficiency virus at University College Hospital, Ibadan were recruited. Venous blood and sputum samples were collected. Sputum samples were cultured for Mycobacterium tuberculosis complex and characterized using standard methods. Anti-TB drug resistance was detected using phenotypic and genotypic methods. Cytokines levels (IL-10 and     IFN-Y) were estimated using ELISA method. Association between cytokines and anti-TB drug resistance was determined using linear regression analysis.  There were 105(48.4%) males and 112(51.6%) females with a mean age of 42.95 ± 8.286 years and a range of 28-65 years. The prevalence of TB among PLHIV was found to be 19.1% with male having higher rate than female (P<0.05), and highest rate among aged ≥40. There was no significant association between cytokines (IL-10 and IFN-y) and sex of the subjects (P>0.05). However, females had higher IFN-y level of 231.06±61.81 IU/ml when compared to 227.53±57.92 IU/ml obtained from males. The prevalence of multi-drug resistance TB was 11.9% with Rifampicin resistance having the highest rate of 5.5%. There was no significant association between cytokines (IL-10 and IFN-y) and sex, but age group >40 years had higher IL-10 and IFN-y level of 226.53±52.39 IU/ml and 232.41±66.63 IU/ml respectively. There was an association between high cytokines levels and anti-TB drug resistance (P<0.05). Highest cytokines levels; IL-10 (401.00±7.07 IU/ml) and IFN-Y (401.00±7.07 IU/ml) were recorded in Levofloxacin resistance. There was an association between high cytokines levels and genotypic anti- TB drug resistance (P<0.05) with highest cytokines levels; IL-10 (400.12±12.37 IU/ml) and IFN-Y (472.87±31.93 IU/ml) recorded in Rifampicin resistance. This entire study revealed that there is high prevalence of MDR-TB among PLHIV, with Rifampicin monoresistance having the highest resistance rate among the drugs tested, and pro and inflammatory cytokines (IL-10 and IFN-y) play significant role in the development of Multi Drug Resistant-Tuberculosis among people living with HIV.