bluuebunny/crossref_metadata_2025 huggingface dataset:
Dictamnine, a Novel c-Met Inhibitor, Suppresses the Proliferation of Lung Cancer Cells by Downregulating the PI3K/Ak/mTOR and MAPK Signaling Pathways
Authors: Yu Jiaojiao , Zhang Lijing , Peng Jun , Ward Richard , Hao Peiqi , Wang Jiwei , Zhang Na , Yang Yang , Guo Xiaoxi , Xiang Cheng , An Su , Xu Tian-rui
Published: October 2020

Background: Dictamnine (Dic), a naturally occurring furoquinoline alkaloid isolated from the root bark of Dictamnus dasycarpus Turcz., is reported to display a wide range of potential pharmacological properties including anticancer activity against multiple cancer types. However, little is known about the direct target proteins and anticancer mechanisms of Dic.Methods: Anticancer effects of Dic and chemotherapy resistance of lung cancer were determined by CCK8, EdU and apoptosis assay. Boyden chamber migration and invasion, wound healing assay, plate colony formation and sphere formation assay were performed to explore the effects of Dic on metastasis and stemness of lung cancer cells. Protein docking analysis, cellular thermal shift assay (CETSA) and drug affinity responsive target stability (DARTS) were used for prediction and confirmation of the interaction between Dic and c-Met. qRT-PCR, Western blotting and immunohistochemistry (IHC) were used in mechanism investigation. Tumor xenograft model was used to evaluate the anti-tumor effects of Dic in vivo.Results: Dic was found to suppress the proliferation of lung cancer cells and attenuate the activation of the PI3K/AKT/mTOR and mitogen-activated protein kinase (MAPK) signaling pathways by directly inhibiting the phosphorylation and activation of the receptor tyrosine kinase c-Met. Moreover, Dic treatment significantly inhibited the colony formation, migration, invasion, stemness, adhesive ability, epithelial-mesenchymal transition and in vivo xenograft tumor growth of A549 lung cancer cells. Notably, the combination of Dic and gefitinib synergistically inhibited the cell proliferation, induced apoptosis, and suppressed the PI3K/Akt/mTOR and MAPK signaling pathways in PC9 gefitinib resistant cells.Conclusions: In conclusion, Dic was identified as a novel c-Met inhibitor and our results suggest the potential use of Dic as a new therapeutic agent in the treatment of lung cancer or other cancers with overactive c-Met pathway.
Automatic detection of pituitary microadenoma from magnetic resonance imaging using deep learning algorithms
Authors: Li Qingling , Zhu Yanhua , Chen Minglin , Guo Ruomi , Liu Hao , Zhang Tiecheng , Wen Huiquan , Gao Rong , Nie Yuanpeng , Li Haicheng , Chen Jian , Shi Guojun , Shen Jun , Cheung Wai , Guo Yulan , Chen Yanming
Published: October 2020

The risks of misdiagnosed pituitary microadenoma is high. We designed a convolutional neural network (CNN) based computer-aided diagnosis (CAD) system to retrospectively diagnose patients with pituitary microadenoma. A total 5,540 pituitary magnetic resonance (MR) images from 1,108 participants were recruited. MRI images were randomly stratified into non-overlapping cohorts (training set, validation set and test set) to establish five different CNN models. The best CNN model is the ResNet with a diagnostic accuracy of 94%, which outperforms the diagnosis accuracy of our radiologists (64%-85%). The accuracy of our CAD system is further confirmed in additional MR datasets. The diagnostic accuracy of our ResNet model is comparable to the proficiency of a radiologist with 5-10 years’ experience. In summary, this is the first report showing that the CAD system is a viable tool for diagnosing pituitary microadenoma. CAD system is applicable to radiology departments, especially in primary health care institutions.
And the Oscar goes to peripheral blood film for detection of lead poisoning in a complicated patient: A case report with review of laboratory clues
Authors: Zamani Amir , Kazerooni Ehsan Sarraf , Kasaee S Saeed , Anbardar Mohammad Hossein , Mohammadzadeh Sahand , Shekarkhar Golsa , Soleimani Neda
Published: October 2020

Background Peripheral blood smear examination is an invaluable laboratory test which provides the complete hematologic and/or non-hematologic picture of a case. In addition to verifying the results of automated cell counters, it has the potential to identify some pathologic morphologic changes that remain hidden using the cell counters alone. Case presentation A 40-year-old man with a 3 year history of alcohol intake and marijuana abuse presented with severe lower extremities bone pain and abdominal pain. Physical examination showed high blood pressure, high pulse rate and abdominal tenderness. He underwent extensive laboratory and imaging tests, and cholecystectomy and bone marrow study, without any definite diagnosis or improvement. Right after all these invasive, expensive and time consuming investigations during a month, finding a point on the peripheral blood smear by an expert led to the final diagnosis. The finding was coarse basophilic stippling in the red blood cells. Elevated blood lead level and the presence of ring sideroblast in the bone marrow study confirmed the diagnosis of lead poisoning and the patient responded well to chelator therapy in a short period. Conclusion This case clearly shows the value of peripheral blood smear review and its impact on the patient care. In order not to lose the cases, laboratories are recommended to design their own policy for peripheral blood smear review. Peripheral blood smear is the fastest, simplest, and most available screening test which could prevent many misdiagnoses and malpractices. It provides rich morphological information, among which basophilic stippling is highly suggestive of lead poisoning.
A Qualitative Analysis of Factors Related to Unsafe Work Behaviors among Environmental Service Workers in the COVID-19 era: Perspectives of Workers, and Safety Managers: The case of Government Hospitals in Addis Ababa, Ethiopia.
Authors: Tamene Aiggan
Published: October 2020

Background: The Environmental service profession is hazardous, partially because of the work's inherently dangerous nature. Thus, injuries, accidents, and illnesses result in substantial financial and social losses. The most common immediate cause of these work-related incidents is unsafe work-behavior; the first step in taking steps to prevent unsafe behavior is to recognize the factors promoting it. The goal of this study was to (a) investigate the attitudes and perceptions of safety among the employees and safety managers of Corona virus treatment hospitals in Addis Ababa, Ethiopia and (b) identify the factors that inhibit safe work behaviors.Methods: Two qualitative data collection approaches, namely key informant interviews and individual in-depth interviews, were used to collect data for this study. Twenty-five participants were recruited from three Corona virus treatment facilities using a modified convenience sampling strategy, and interviews were conducted to gain a detailed understanding of factors that serve as barriers to safe work behavior. The interviews were recorded and transcribed in Amharic (the local language) and then translated into English. Open Code 4.02 was used for thematic analysis.Results: Poor safety management and supervision, unsafe work environment, and perceptions, skills, and training level of employees were established as the major factors associated with the prevailing unsafe work behavior among environmental service employees.Conclusions: The present study showed that different types of personal and environmental factors may discourage safe work behavior among environmental service workers. To minimize or remove these risk factors for unsafe behaviors, the individual's obligation is important, but the role of management is critical in providing resources for safe work behavior.
Effects of integrated application of plant-based compost and urea on soil food web, soil properties, and yield and quality of a processing carrot cultivar
Authors: Habteweld A. , Brainard D. , Kravchencko A. , Grewal P. S. , Melakeberhan H.
Published: October 2020

Soil nutrient management system characterized by reduced input of inorganic fertilizers integrated with organic amendments is one of the alternatives for reducing deleterious environmental impact of synthetic fertilizers, suppressing soil-borne pests and diseases, and improving soil health and crop yield. A hypothesis of the present study was that lower rates of urea mixed with higher rates of plant compost (PC) would improve nematode community structure, soil food web condition, soil biological, and physiochemical properties, and yield and quality of a processing carrot (Daucus carota) cultivar. Urea and PC were each applied at 135 kg nitrogen (N)/ha alone or at 3:1, 1:1, and 1:3 ratios annually during the 2012 to 2014 growing seasons. A non-amended check served as a control. Nematode community was analyzed from soil samples collected approximately 4-week intervals from planting to 133 days after planting each year. Soil respiration, as a measure of soil biological activity, and soil physiochemical properties were determined from soils collected at planting and at harvest in 2012 and 2013. Results showed that PC alone, and U1:PC1 resulted in soil food web structure significantly above 50 at harvest in 2014. Urea significantly decreased end-of-season soil pH, but increased NO3-N compared with the other treatments. While the herbivore population density was low, abundances of Tylenchus and Malenchus were negatively correlated with carrot fresh weight of marketable carrot. Overall, results suggest that integrating lower rates of urea and higher rates of PC are likely to increase soil biological activity, soil pH, and phosphorus content.
Parasites of the alimentary tract of European otters in Bory Tucholskie National Park
Authors: P. Górski , K Lubińska , J. Karabowicz , J. Bartosik , W. Zygner
Published: October 2020

The aim of the study was to investigate the intestinal parasites of European otters (Lutra lutra) living in Bory Tucholskie National Park. The park is located in northern Poland, in the Pomeranian Voivodeship. From June to October 2019, 300 fecal samples were collected on the banks of 10 lakes and the Struga river within the national park. The samples were kept at 4°C for a maximum of 3 weeks until examination. Standard flotation (in sodium chloride aqueous solution) and sedimentation methods were used. The total percentage of positive samples containing parasites of the alimentary tract amounted to 15.3% (46 samples). Oocysts Cystoisospora gottschalki were found in 6.7% of samples, trematode eggs (Opisthorchis sp., Metorchis sp. and/or Pseudamphistomum truncatum, Alaria alata and/or Isthmiophora melis) in 4.3%, cestode eggs of the family Diphyllobothridae in 2.0%, and eggs of nematodes (Strongyloides lutrae, Aonchotheca putori, Uncinaria sp.) in 3.7% of samples. Two species, C. gottschalki and S. lutrae, were found in Poland for the first time. The large variety of parasite species is evidence of well-preserved local ecosystems.
Comet assay as a method used in research on DNA damage caused by pesticides in fish
Authors: M. Księżarczyk , P. Leśniak , B. Arciszewski M. , L. Valverde Piedra J.
Published: October 2020

The comet assay method is a research technique for detecting damage to cellular DNA due to active physical or chemical agents. The comet assay is based on electrophoretic migration of genetic material contained in the cell’s nucleus. This research method is commonly used in many different fields, such as toxicology, environmental protection, and pharmacology. In recent years, the comet assay has attracted considerable attention from scientists studying the effects of harmful substances on the genetic material in the cell’s nucleus. The presence of pesticides in the environment is a threat to animals, because of the negative effects of pesticides on cells and their genetic material. Therefore, the aim of this paper, based on the available literature, was to describe the use of the comet assay in assessing the genotoxicity of pesticides to cells of aquatic organisms, as well as to describe the methodology and potential complications of this procedure.
Role of „oncobacteria” in oncogenesis: Selected examples
Authors: A. Madej J.
Published: October 2020

Helicobacter pylori plays a particular role among “oncobacteria” and was recognized by IARC as a group I carcinogen. In the stomach of humans and animals, it induces two histologically distinct types of tumors: adenocarcinoma (epithelial tumor) and B-cell lymphoma (mesenchymal tumor), which never occur simultaneously in the same individual. An attempt was made at explaining this phenomenon on the basis of the mutual relationship between the host and the bacteria (Fig. 1).
Flood mitigation in coastal urban catchments using real-time stormwater infrastructure control and reinforcement learning
Authors: Bowes Benjamin D. , Tavakoli Arash , Wang Cheng , Heydarian Arsalan , Behl Madhur , Beling Peter A. , Goodall Jonathan L.
Published: October 2020

Flooding in coastal cities is increasing due to climate change and sea-level rise, stressing the traditional stormwater systems these communities rely on. Automated real-time control (RTC) of these systems can improve performance, and creating control policies for smart stormwater systems is an active area of study. This research explores reinforcement learning (RL) to create control policies to mitigate flood risk. RL is trained using a model of hypothetical urban catchments with a tidal boundary and two retention ponds with controllable valves. RL's performance is compared to the passive system, a model predictive control (MPC) strategy, and a rule-based control strategy (RBC). RL learns to proactively manage pond levels using current and forecast conditions and reduced flooding by 32% over the passive system. Compared to the MPC approach using a physics-based model and genetic algorithm, RL achieved nearly the same flood reduction, just 3% less than MPC, with a significant 88× speedup in runtime. Compared to RBC, RL was able to quickly learn similar control strategies and reduced flooding by an additional 19%. This research demonstrates that RL can effectively control a simple system and offers a computationally efficient method that could scale to RTC of more complex stormwater systems.
The Image of Knyaz Vladimir in Popular Literature (The Second Half of XIX Century)
Authors: Pozdniakov Aleksandr Nikolaevich
Published: October 2020

The article analyzes the literature published in the second half of the XIX century for popular reading, dedicated to the life and work of Prince Vladimir of Kiev. One of the main results of his activity was the adoption of Christianity in Russia. This had a profound impact on the political, social and cultural life of the country. Literature for popular reading formed in the minds of people the image of Prince Vladimir as an extraordinary person, a simple and at the same time a great man. He is shown as a statesman who transformed the country, laid the foundations of a new civilization, and simultaneously became a national hero.
Pills or Sleep Deprivation? Sleep-Deprivation as a Therapeutic Option Intervention in Psychiatry
Authors: Antsyborov Andrey Viktorovich , Dubatova Irina Vladimirovna , Kalinchuk Anna Valerievna
Published: October 2020

In recent decades, sleep deprivation has evolved from a single experimental data set to the status of an effective and affordable therapeutic intervention used in daily clinical practice. The mechanism of action of this method is aimed at the same neurotransmitter systems and brain regions as antidepressants. As in the case of pharmacotherapy for sleep deprivation, it should be used under close supervision of a physician. Clinical effects with sleep deprivation are achieved much faster than with psychopharmacotherapy, but they are not long-term in nature. It is possible to improve the results using a combination of pharmacotherapy and sleep deprivation. The use of sleep deprivation in clinical conditions is aimed primarily at preventing depression and its recurrence, as well as in cases resistant to pharmacotherapy. In modern conditions, the method of sleep deprivation is a significant alternative to traditional approaches to therapy of depression.
A forma-escola inovadora
Authors: Regina Gomes Neves Antônia , De Mello Hetti Bahia Sabrine Borges , Henn Fabris Elí Terezinha
Published: October 2020

Este artigo apresenta resultados de um estudo sobre escolas inovadoras, com vistas a investigar e problematizar os deslocamentos do que Jacques Rancière (1988) nomeia de “forma-escola”, descrevendo e analisando como esse conceito opera em tais escolas. O material empírico foi constituído por 12 episódios de documentários da série Destino Educação: Escolas Inovadoras, produzida pelo Canal Futura. A metodologia utilizada foi análise de discurso, em uma perspectiva foucaultiana. Utilizaram-se as teorizações sobre formação de professores, inovação e estudos foucaultianos. Identificamos que as escolas analisadas mantêm, ainda que de forma profanada (LARROSA, 2017), os cinco elementos da “forma-escola” (tempo, espaço, materiais, atividades e sujeitos), com diferentes ênfases e de diferentes modos. Os elementos da “forma-escola” estão presentes nas escolas inovadoras e que essa forma profanada é o que constitui a forma-escola inovadora.
Antitumorigenic Effect of Memantine via Interfering Glutamate Metabolism in Mouse 4T1 Breast Tumor Model
Authors: Albayrak Gulsah , Korkmaz Funda D. , Bali Elif B. , Bagriacik Emin U.
Published: October 2020

Background:

Repurposing drug is an efficient strategy as the drug discovery process is timeconsuming,
laborious and costly. Memantine is already used in Alzheimer’s disease to prevent neurons from
excess glutamate toxicity. As cancer cells benefit from higher amounts of cellular energetics like glucose and
glutamine, we used memantine to interfere with the glutamate metabolism in order to restrict cancer cells'
glutamine as a source for their growth.

Objective:

To investigate the potential antitumor effect of memantine by reducing glutamate levels in 4T1 mouse
breast cancer model.

Methods:

24 Balb/c female mice were subcutaneously inoculated with 4T1 cells. When tumors were palpable,
memantine treatment was initiated as 5 and 10 mg/kg daily intraperitoneal injection. Tumor growth was recorded
every 2–3 days. Tumor volumes, serum glutamate levels, spleen IL-6 levels, genome-wide DNA methylation
levels and GSK3B. pGSK3B protein expressions were measured to enlighten the anticancer mechanism of action
for memantine.

Results:

We found that both two doses (5 and 10mg/kg) decreased tumor growth rates and serum glutamate
levels significantly (p<0.05). 10mg/kg treatment increased spleen IL-6 levels (p<0.05) and decreased genomewide
DNA methylation levels. Memantine treatment decreased GSK3B protein expression levels in tumor tissue
samples.

Conclusion:

To the best of our knowledge, this is the first study that investigates the antitumor activity of
memantine in a breast cancer tumor model. Our results suggest a potent anticancer mechanism of the action for
memantine. Memantine decreased genome wide methylation and serum glutamate levels that are associated with
a poor prognosis. Therefore, Memantine might be used for targeting glutamine metabolism in cancer treatment.
Some Valency Oriented Molecular Invariants of Certain Networks
Authors: Salman Muhammad , Ali Faisal , Masood Ur Rehman  , Khalid Imran
Published: October 2020

Background:

The valency of an atom in a molecular structure is the number of its neighboring atoms. A large
number of valency based molecular invariants have been conceived, which correlate certain physio-chemical properties like
boiling point, stability, strain energy and many more of chemical compounds.

Objective:

Our aim is to study the valency based molecular invariants for four hexa chemical structures, namely hexagonal
network, honeycomb network, oxide network and silicate sheet network.

Method:

We use the technique of atom-bonds partition according to the valences of atoms to find results.

Results:

Exact values of valency-based molecular invariants, namely the Randić index, atom bond connectivity index,
geometric arithmetic index, harmonic index, Zagreb indices, Zagreb polynomials, F-index and F-polynomial are found for
four hexa chemical structures.
Astrid Burgbacher: Moralische Intuition
Authors: Mamin Cyrill
Published: October 2020

Rezension zu: Astrid Burgbacher, Moralische Intuition. Eine Annäherung an einen mentalen Zustand. Paderborn: mentis 2018.
Pengaruh penggunaan aplikasi Plantnet dan gaya belajar terhadap hasil belajar
Authors: Pujianto Anton Adhy , Degeng I Nyoman Sudana , Sugito Sugito
Published: October 2020

Tujuan dari penelitian ini adalah: 1.) Untuk mengetahui pengaruh penggunaan aplikasi PlantNet terhadap hasil belajar; 2.) Untuk mengetahui pengaruh gaya belajar terhadap hasil belajar; dan 3.) Untuk mengetahui interaksi antara peng-gunaan aplikasi PlantNet dan gaya belajar terhadap hasil belajar IPA siswa kelas VII. Metode penelitian ini menggunakan penelitian eksperimen. Penelitian dilak-sanakan pada tanggal 20 Januari 2020 sampai dengan 14 Maret 2020. Populasi dalam penelitian ini sebanyak 32 kelas dengan jumlah sebanyak 1.088 siswa kelas VII ditiga sekolah yaitu SMP Negeri 2 Gedangan, SMP Negeri 3 Sidoarjo, dan SMP Negeri 4 Sidoarjo. Teknik pengambilan sampel penelitian menggunakan simple random sampling, pengambilan sampel secara acak sederhana melalui nomor undian. Dalam pengambilan sampel didapat 3 kelas eksperimen penggunaan aplikasi PlantNet dan 3 kelas kontrol tanpa aplikasi PlantNet menggunakan diskusi kelas. Teknik analisis data menggunakan Anava dua jalur dengan nilai signifikansi sebesar α = 0,05. Hasil penelitian ini menunjukkan bahwa: 1.) Ada-nya  pengaruh penggunaan aplikasi PlantNet terhadap hasil belajar IPA siswa kelas 7; 2.) Adanya pengaruh gaya belajar terhadap hasil belajar IPA siswa kelas 7; dan 3.) Adanya interaksi antara penggunaan aplikasi PlantNet dan gaya belajar terhadap hasil belajar IPA siswa kelas VII. AbstractThe objectives of this study are: 1.) To determine the effect of using the PlantNet application on learning outcomes; 2.) To determine the effect of learning styles on learning outcomes; and 3.) To determine the interaction between the use of the PlantNet application and learning styles on the learning outcomes of 7th grade science students. This research method uses experimental research. The study was conducted on January 20 until March 14, 2020. The population in this study was 32 classes with a total of 1,088 7th grade students in three schools, namely SMP Negeri 2 Gedangan, SMP Negeri 3 Sidoarjo, and SMP Negeri 4 Sidoarjo. The research sampling technique uses simple random sampling, simple random sampling through lottery numbers. In sampling obtained 3 experimental classes using the PlantNet application and 3 control classes without the PlantNet application using class discussion. Data analysis technique used two-way Anava with a significance value of α = 0.05. The results of this study indicate that: 1.) The influence of the use of the PlantNet application on the learning outcomes of the 7th grade science students; 2.) The influence of learning styles on the results of science learning for 7th grade students; and 3.) There is an interaction between the use of the PlantNet application and learning styles on the learning outcomes of 7th grade science students.
The Impact of Reducing the Number of Wearable Devices on Measuring Gait in Parkinson Disease: Noninterventional Exploratory Study
Authors: Czech Matthew , Demanuele Charmaine , Erb Michael Kelley , Ramos Vesper , Zhang Hao , Ho Bryan , Patel Shyamal
Published: October 2020

Background

Measuring free-living gait using wearable devices may offer higher granularity and temporal resolution than the current clinical assessments for patients with Parkinson disease (PD). However, increasing the number of devices worn on the body adds to the patient burden and impacts the compliance.

Objective

This study aimed to investigate the impact of reducing the number of wearable devices on the ability to assess gait impairments in patients with PD.

Methods

A total of 35 volunteers with PD and 60 healthy volunteers performed a gait task during 2 clinic visits. Participants with PD were assessed in the On and Off medication state using the Movement Disorder Society version of the Unified Parkinson Disease Rating Scale (MDS-UPDRS). Gait features derived from a single lumbar-mounted accelerometer were compared with those derived using 3 and 6 wearable devices for both participants with PD and healthy participants.

Results

A comparable performance was observed for predicting the MDS-UPDRS gait score using longitudinal mixed-effects model fit with gait features derived from a single (root mean square error [RMSE]=0.64; R2=0.53), 3 (RMSE=0.64; R2=0.54), and 6 devices (RMSE=0.54; R2=0.65). In addition, MDS-UPDRS gait scores predicted using all 3 models differed significantly between On and Off motor states (single device, P=.004; 3 devices, P=.004; 6 devices, P=.045).

Conclusions

We observed a marginal benefit in using multiple devices for assessing gait impairments in patients with PD when compared with gait features derived using a single lumbar-mounted accelerometer. The wearability burden associated with the use of multiple devices may offset gains in accuracy for monitoring gait under free-living conditions.
Berdaya di Era Pandemi: Peran Corporate Social Responsibility dalam Penanggulangan COVID-19
Authors: Sitorus Siti Hazar , Hidayat Rahmad
Published: October 2020

Artikel ini bertujuan untuk mengeksplorasi program tanggung jawab sosial oleh Pertamina Sungai Pakning dalam penanggulangan pandemi COVID-19 di Kelurahan Sungai Pakning. Dengan menggunakan metode studi kasus melalui penyajian secara deskriptif, artikel ini berhasil menemukan bahwa kegiatan tanggung jawab sosial perusahaan dalam menanggulangi pandemi yang menggunakan tiga strategi, yaitu donasi, peningkatan kapasitas dan pemberdayaan masyarakat. Ketiga strategi ini mampu menjawab kebutuhan masyarakat dan mendorong terbangunnya sinergisitas antara perusahaan dengan instansi pemerintah dalam upaya penanggulangan pandemi.Kata Kunci: tanggung jawab sosial; COVID-19; upaya penanggulangan pandemi

This article aims to explore Pertamina Sungai Pakning’s Social Responsibility Program in tackling the COVID-19outbreak in Sungai Pakning. By using a case study method with a descriptive presentation, this article succeeds to find that corporate social responsibility activities in tackling a pandemic by used three strategies, namely charity, capacity building and community empowerment, which these three strategies are able to answer people needs and as to build synergy between company and government agency in efforts to overcome the pandemic.Keywords: corporate social responsibility; COVID-19; pandemic countermeasures
Ketahanan Sosial Berbasis Kelompok Peduli Lingkungan dalam Menghadapi Pandemi COVID-19: Studi pada Gerakan Bersih Kecamatan Anggana
Authors: Aldita Cindy Arfidiandra  , Rahmaningrum Riana , Luthfi Wazirul
Published: October 2020

Memasuki tahun 2020, dunia dihadapkan dengan kemunculan wabah infeksi Coronavirus Disease 2019 (COVID-19). Kemunculan wabah tersebut berdampak pada aspek kehidupan masyarakat yang mendorong adanya perubahan. Hal ini menjadikan institusi sosial seperti Gerakan Bersih Kecamatan Anggana (GBKA) berupaya menghadapi perubahan tersebut. Tujuan penelitian ini adalah mendeskripsikan upaya GBKA mewujudkan ketahanan sosial melalui cara dan pendekatan kelompok dalam menghadapi kondisi pandemi COVID-19. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan deskriptif. Penelitian ini menemukan bahwa unsur “Betulungan” atau tolong menolong sebagai nilai kearifan lokal yang dimiliki masyarakat berperan penting dalam dinamika kelompok untuk mewujudkan ketahanan sosial. “Betulungan” menjadi potensi dalam rangkaian proses adaptasi kelompok guna mempertahankan eksistensi GBKA di tengah pandemi COVID-19. Kata Kunci: ketahanan sosial; kelompok sosial; adaptasi; kerentanan

At the beginning of 2020, the world is overcoming an outbreak of Coronavirus Disease 2019 or known as COVID-19. The outbreak has disrupted community’s lives which leads to social change. In fact, like the roles of another social institution, GBKA tries to overcome this social changes. The study aims to describe GBKA’s efforts to achieve social resilience through a community approach in this pandemic COVID-19 situation. The research uses descriptive qualitative approach. This study found that the element of “Betulungan” or known as mutual assistance as the value of local wisdom owned by the community has an important role of community to achieve social resilience. “Betulungan” is a capital in a process of adaptation of community group in order to maintain the sustainability of the group in this COVID-19 pandemic situation.Keywords: social resilience; community group; adaptive capacity; vulnerabilities
Suggested Research Agenda for the Railroad Industry
Authors: Jennings Barton
Published: October 2020

The railroad industry is experiencing a worldwide resurgence. International trade is booming as populations continue to grow and transportation infrastructures are nearing capacity. In the United States, the industry is being pressured to provide more services, while at the same time traffic levels are skyrocketing on a network that is much smaller than it was just fifty years ago. Additionally, security and safety issues are challenging the industry, as well as the regulatory agencies associated with railroading. To help with these problems, the industry is calling for more academic involvement through new degree programs and research initiatives. This paper reviews five major areas where academic research could assist the railroad industry in these challenges: capacity expansion, service standards, safety, security, and data management and analysis.
Evaluating the Comparative Efficiency of Eleven States’ Highway Expenditures
Authors: Min Hokey , Lambert Thomas
Published: October 2020

In an era of budget deficits and financial cutbacks, the efficiency of state highway finances dictates future investment in road construction and maintenance. Considering the significant impact of highway infrastructure on the survival and competitiveness of the logistics industry, this paper aims to develop a meaningful set of benchmarks that will guide the state government authority in making wise investment decisions regarding road construction and maintenance. In particular, we propose a data envelopment analysis that is proven to be useful for measuring the operational efficiency of various profit or non-profit organizations. Using the examples of state highway finances for Kentucky and other comparable states in the United States, this paper illustrates the usefulness of data envelopment analysis for the efficient allocation of financial resources to road construction and maintenance.
Transportation management systems: an exploration of progress and future prospects.
Authors: Griffis Stanley E , Goldsby Thomas J
Published: October 2020

This research reports the experiences of both adopters and non-adopters of transportation management system (TMS) technology. TMS adopters represent a diverse array of companies, with a surprisingly high percentage of adopters using outsourced services for decision support activities. Motives for adoption tend to align with the firm’s strategic needs though functionality focuses on the shipper’s day-to-day operational needs. While expectations of system performance and return on investment vary greatly, TMS users illustrate a generally high level of satisfaction. Non-adopters view decision support for transportation activities as a low priority. The article explores future prospects for TMS development and adoption.
Evaluation of an expanded satellite based mobile communications tracking system
Authors: Novak Maciek A , Erera Alan L
Published: October 2020

Since the terrorist events in the United States on September 11, 2001, the Federal Motor Carrier Safety Administration has been testing and evaluating cargo tracking technologies to improve the safety, security, and efficiency of commercial motor vehicle operations. While satellite-based systems used for tracking vehicles and cargo provide sufficient geographic coverage in the majority of the United States, there remain several vital regions that are uncovered and difficult to monitor. One such region is Alaska, where officials arc particularly concerned with the hazardous materials shipments that are transported parallel to the Trans-Alaska Pipeline. This article analyzes the risks and benefits associated with adopting an Expanded Satellite-Based Mobile Communications Tracking System to monitor hazardous materials and high-value cargo in Alaska. Technical and acceptance risks are evaluated against the communication, safety, security and real time information benefits that the system provides. The findings indicate that the system provides a significant communications upgrade relative to previously available technology.
A financial analysis of the interstate commerce commission (ICC) termination act of 1995 on the motor carrier industry
Authors: Hanna Joe B , Kunkel Robert A , Kuhlemeyer Gregory A
Published: October 2020

Since the late 1970's the United States has progressively deregulated the motor carrier industry. Throughout the 1980's, deregulation was viewed as a positive trend by most industry practitioners. Past research has determined that, despite the fact that bankruptcies have increased since deregulation, the motor carrier industry has benefitted by less government intervention. The current study attempts to ascertain if motor carrier deregulation is still perceived positively in the mid-1990's. This research uses an event study methodology to examine the immediate financial impact of the ICC Termination Act of 1995 on 44 motor carrier industry participants. The results indicate deregulation is still perceived positively by shareholders as illustrated by the average publicly traded motor carrier benefittingby between $1.25 million and $6.1 million duringthe period surrounding termination of the Interstate Commerce Commission. In all likelihood, shareholders of companies in this industry benefitted due to the perception that industry deregulation leads to the ability to expand and pursue business opportunities previously restricted while operatingunder a more regulated regime.
Revisiting logistical friendliness: perspectives of international freight forwarders
Authors: Murphy Paul R , Daley James M
Published: October 2020

Logistical friendliness (unfriendliness) refers to the ease (difficulty) of arranging international freight operations to/from a particular country. The present paper builds upon previous research by 1) examininglogistical friendliness and unfriendliness as two different constructs (rather than as opposite ends of the same continuum), and 2) linking the delineation of logistically friendly and unfriendly countries with the reasons for friendliness (unfriendliness). The study results could be quite valuable with corporate decisions as to which countries to do business in, as well as with the appropriate organizational strategies for entering the chosen countries.
Maritime unions and the U.S. merchant marine
Authors: Clarke Richard L
Published: October 2020

U.S. maritime unions have played a vital historical role in both the defense and the economic development of the United States. The economic and the political forces that helped shape and promote the growth of U.S. seafaring labor unions changed dramatically in the 1990s. Maritime union membership in the United States has fallen by more than 80 per cent since 1950. Inflexible union work rules and high union wage scales have contributed to this decline. Recent regulatory and industry changes require a new union approach if U. S. maritime unions are to survive the next decade.
Defining dyadic cost and risk in international trade: a review of incoterms 2000 with strategic implications
Authors: Stapleton Drew M , Saulnier Virginie
Published: October 2020

As trade markets continue to expand due to developments in transportation and logistics technologies, distribution networks extend well beyond national frontiers. With obstacles such as distance, language, and business customs, allocation of legal responsibility between a buyer and a seller of goods becomes even more crucial in international commerce. This document is presented in three general sections. Reviewing the basics, including definition, origin, use and classifications of INCOTERMS constitutes the first section. The second section describes and analyzes the differences between each of the 13 INCOTERMS 2000. Lastly, the changes introduced by the 2000 revision are studied in more detail in section three and implications are proffered.
Leading without bleeding: an information technology case study at union pacific railroad
Authors: Gupta Uma G , Butler Randy W , Milner Thomas D
Published: October 2020

In the railroad industry, the ability to assess damages to rail units in an accurate and timely manner is critical to the success and profits of a company. Accurate damage assessment of rail units also plays a key role in dispute resolution and negotiation with key vendors and suppliers (my.uprr.com/pub/dam-prev). This paper describes and presents information about Union Pacific Railroads (UPRR) and Science Applications International Corporations (SAIC) highly successful efforts in fully automating the data collection, inspection, assessment and reporting of damage claims to rail equipment. UPRR and SAIC used an innovative and highly creative approach to develop and implement the Automated Gate System (AGS) by integrating a portfolio of leading edge high resolution imaging and optical character recognition technologies. AGS is a unique and revolutionary system in the transportation industry and has yielded significant strategic and long-term benefits to the company. The reengineering efforts that preceded the development of the system have helped the company to sustain its position as a leader in the railroad industry.
Antioxidant contents in potato cultivars from the collection of Russian Potato Research Center
Authors: Gins Ekaterina Muratovna , Moskalev Evgeny Aleksandrovich , Polivanova Oksana Borisovna , Mityushkin Aleksey Vladimirovich , Simakov Evgeny Alekseevich
Published: October 2020

Antioxidants protect not only plants, but also humans from oxidative stress. Plant antioxidants include phenolic compounds: phenolic acids, flavonoids, anthocyanins, and vitamin C. Potatoes are one of the most consumed crops in the world and can serve as a promising source of antioxidants in the human diet. The aim of the study was to compare secondary low-molecular-weight antioxidants (ascorbic acid, phenolic compounds, flavonoids, total antioxidant content) in 15 cultivars of potatoes with pigmented and white pulp ( Solanum tuberosum L.) to identify genotypes having increased antioxidant activity. The research was conducted in 2019, a week after harvesting. Plants were grown on sod-podzolic soils in the fields of Federal Scientific Vegetable Center. Analysis of the total content of soluble phenolic compounds showed that almost all the studied varieties contained significantly more phenolic compounds in the skin than in the pulp. The maximum level of phenolic compounds was found in Monarkh (purple pulp) and Vympel (light yellow pulp) - 69.33 mg/100 g and 67.93 mg/100 g of fresh mass, respectively. The highest amount of flavonoids was observed in Zhukovsky ranniy (white pulp) and Tayfun (white pulp) - 12.49 mg/100 g and 11.06 mg/100 g of fresh mass, respectively. The highest content of ascorbic acid was determined in Gala (dark yellow pulp) - 15.84, Golubizna (white pulp) and Red Scarlett (yellow pulp) - 14.08 mg%. The maximum total content of hydrophobic antioxidants was found in Zhukovsky ranniy (white pulp) - 0.38 mg. eq. HA/g and Red Scarlett (yellow pulp) - 0.37 mg. eq. HA/g.
Evaluation of yield and its components for some flax genotypes
Authors: Omar Taha Ahmed
Published: October 2020

Sixteen flax ( Linum usitatissimum L.) genotypes were evaluated at Gemmeiza Agricultural Research Station, Agricultural Research Center, El-Gharbia Governorate, Egypt during the two successive seasons 2015/2016 and 2016/2017. Randomized complete block design with three replications was used. Phenotypic and genotypic coefficients of variation for all studied traits had closely values. High heritability coupled with high genetic advance (as % of mean) for most studied traits. Plant height, technical length and stem diameter were the best selection indices to improve straw yield /plant, along with number of branches, capsules and seeds were effective selection criteria for improving seed yield /plant as proven by phenotypic and genotypic correlation
Cfa-miRNAs-122 and -21 as modern biomarkers of primary hepatitis in dogs
Authors: El-Sebaey Ahmed Mohammed Hassan , Abramov Pavel Nikolaevich , Borunova Seidfatima Mirovna
Published: October 2020

Primary hepatitis (PH) is one of the most frequently diagnosed hepatic diseases in dogs. Its popular forms are acute hepatitis (AH) and chronic active hepatitis (CAH) which can progress to hepatic fibrosis and cirrhosis. This investigation aimed to evaluate the use of hepatocyte released Canine familiaris miRNAs(cfamiR)-122 and -21 as serum biological markers for the early and reliable diagnosis of PH and to reveal the onset of hepatic fibrosis. After the ultrasonographic and histological examination, fifteen healthy dogs were involved in the study as control group to compare with other thirty dogs confirmed to have AH or CAH (n = 15). Activity of liver enzymes as well as serum level of globulin and total bilirubin were significantly elevated in AH (P 0.001) and CAH (P 0.01) groups whereas, serum level of total protein, albumin, BUN and A/G ratio were significantly lowered in both PH groups (P 0.01) compared to control. Cfa-miR-122 significantly expressed in AH (P 0.001) and CAH (P 0.01) and exhibited a potential significance in distinguishing these groups from control with an area under the curve (AUC) of 0.98 and 0.96, respectively. Additionally, cfa-miR-122 displayed a potential role in distinguishing AH (P 0.05) from CAH group with an AUC of 0.85. Cfa-miR-21 was only expressed in dogs of CAH group and displayed a potential role in distinguishing this group (P 0.001) from AH and healthy groups with an AUC of 0.99 and 0.88, respectively. Therefore, cfa-miR-122 can be significantly expressed in dogs with two forms of PH whereas, cfa-miR-21 could be potentially enhanced only in chronic form of PH and may act as new non-invasive biomarker for distinguishing AH from CAH.
ICT competence formation model of a future primary school teacher
Authors: Beshenkov Sergey A. , Matveeva Valentina A.
Published: October 2020

Problem and purpose. The article is devoted to the problem of the formation of ICT competence in future primary school teachers. In the context of global mass communication, the most valuable resource today is the ability to analyze, systematize, and interpret information. Global informatization naturally affects the education process and the main task of the education system is to identify current trends in the development of society and introduce pedagogical technologies into the educational process that form positive experience and reflect modern social changes, leading the educational process into an ordered, controlled system. The aim of the study is to find effective ways of manifesting information activities, building a model that promotes the development of ICT competence in future primary school teachers by means of mathematical cycle disciplines. Methodology. During the study, an analysis of approaches to the creation of educational models was carried out, ways of developing ICT competence of future primary school teachers by means of mathematical cycle disciplines were revealed. The main conceptual idea of the model, contributing to the solution of the didactic problems (epistemological, axiological, praxeological, professional-personal, communicative), is the reflection of mathematics in the information field as an instrument of humanization of the modern information society and personality. The basic aspects of fragmented subject modeling of pedagogical reality is the application of an integrated approach to the conceptual, criteria and quantification of the model. Results. A model for the development of ICT competence of future primary school teachers has been developed. The technological component of the model is disclosed, the criterion component of which is represented by the matrix of conjugation of levels (elementary, sufficient, advanced) and components of ICT competency (epistemological, axiological, praxiological, professional-personal, communicative). Each component is revealed through the prism of knowledge, skills and experience. Conclusion. The developed model for the development of ICT competence of future primary school teachers by means of the mathematical cycle disciplines justifies itself in practice and needs further research and quantitative analysis.
Integration of natural science and humanities knowledge in the teaching of applied mathematics to students in the conditions of informatization of education
Authors: Kornilov Viktor S.
Published: October 2020

Problem and goal. The success of a variety of applied research based on achievements in applied mathematics presupposes the existence of highly qualified professionals with not only fundamental knowledge in applied mathematics, but applied mathematical thinking and the world of information, able to apply environmental technologies in applied research, to formulate and justify inferences about the results of the study. Such specialists in applied mathematics are able to identify and understand the new information obtained as a result of research in terms of its scientific and humanitarian value. That is why much attention is paid to the training of such highly professional specialists in the field of applied mathematics in Russia. Methodology. In the process of teaching applied mathematics to students of physics and mathematics and natural science areas of higher education, it is advisable to integrate natural science, humanities, and information technology. At the same time, it is necessary to attract specialists in the field of applied mathematics who have experience in using information technologies to solve applied mathematical problems. Results. The integration of natural science, humanities, and information technologies in the process of teaching applied mathematics allows students to develop a scientific worldview and information culture, to better understand the approaches and methods of applied mathematics as well as the scientific potential of applied mathematics. In addition, this integration allows to identify the fundamental concepts of scientific disciplines, which may not be the basic disciplines for teaching in the field of applied mathematics, but at the same time, play an important role in the methodology of applied mathematics. For example, such disciplines include computer science, philosophy, etc. Conclusion. Training classes with students in applied mathematics, which integrates natural science, humanities, information technology allows to identify the humanitarian, scientificeducational and scientific-educational potential of teaching applied mathematics to justify the positive contribution of information technology to develop students ICT competence.