bluuebunny/crossref_metadata_2025 huggingface dataset:
A Correlation Study between Clinical Efficacy of Weifuchun on Precancerous Lesions of Gastric Cancer and Intestinal flora
Authors: Bian Yanqin , Chen Xi , Cao Hongyan , Xie Dong , Zhu Meiping , Yuan Nong , Lu Lu , Lu Bingjie , Wu Chao , Azami Nisma Lena Bahaji , Wang Zheng , Wang Huijun , Zhang Yeqing , Li Kun , Sun Mingyu , Ye Guan
Published: June 2021

BackgroudWeifuchun(WFC), a Chinese herbal prescription consisting of Red Ginseng, Isodon amethystoides and Fructus Aurantii, is commonly used in China to treat a variety of chronic stomach disorders. The aim of the paper is to determine the effect of WFC on intestinal microbiota changes in precancerous lesions of gastric cancer (PLGC) patients. MethodsPLGC patients of H.pylori negative were randomly divided into two groups received either WFC tablets at a dose of 1.44g 3 times a day or vitacoenzyme tablets at a dose of 0.8g 3 times a day. All patients were treated for 6 months, consecutively. Gastroscopy and histopathology were used to assess the histopathological changes in the gastric tissues before and after treatment. 16S rRNA gene sequencing was carried out to assess the effects WFC on intestinal microbiota changes in PLGC patients. Receiver Operating Characteristics(ROC) analysis was used to assess the sensitivity and specificity of different intestinal microbiota in distinguishing between PLGC patients and healthy control. ResultsGastroscopy and histopathological results indicated that WFC could improve the pathological condition of PLGC patients, especially in the atrophy or intestinal metaplasia. The results of 16S rRNA gene sequencing indicated that WFC could regulate the microbial diversity, microbial composition, and abundance of the intestinal microbiota of PLGC patients. Following WFC treatment, the relative abundance of Parabacteroides was decreased in WFC group when compared with the control group. ROC analysis found that the Parabacteroides could effectively distinguish PLGC patients from healthy individuals with sensitivity of 0.79 and specificity of 0.8. ConclusionsWFC could slow down the progression of PLGC by regulating intestinal microbiota abundance. Trial registrationNCT03814629. Name of registry: Randomized Clinical Trial: Weifuchun Treatment on Precancerous Lesions of Gastric Cancer. Registered 3 August 2018-Retrospectively registered, https://register.clinicaltrials.gov/ NCT03814629.
The Impact of Atrial Fibrillation on Quantitative Flow Ratio Measurements in Patients With Coronary Artery Disease
Authors: Lu Wenbin , Zhang Xiaoguo , Wang Dong , Ma Genshan , Chen Lijuan , Dai Qiming
Published: June 2021

Quantitative Flow Ratio (QFR) is now a new method for the assessment of the extent of coronary artery stenosis but may be obscured by involvement of the mutated status of anatomical structure and blood flow in the coronary artery when encountering Atrial Fibrillation (AF). In this study, we aimed to expose the effect of mutated status of anatomical structure and blood flow on QFR results in AF patients. Methods and results: We evaluated QFR on 223 patients (112 patients with AF; 111non-AF patients served as control) who had undergone PCI-ES due to severe stenoses in coronary arteries. QFR of the target coronary was determined according to the flow rate of the contrast agent, results showed that AF patients with significantly higher QFR value than control group (0.792 ± 0.011 vs. 0.685 ± 0.016, p＜0.001). Then we further analyzed the local QFR around the stenoses (0.858 ± 0.0287 vs. 0.756 ± 0.014, p=0.002), residual QFR (0.958 ± 0.005 vs. 0.929 ± 0.009, p=0.005), index QFR (0.807 ± 0.010vs. 0.713 ± 0.014, p<0.0001) in these two groups of patients with and without AF. Further analysis revealed that AF patients accompanied with relatively lower blood flow velocity (0.130 ± 0.006 m/s vs. 0.153 ± 0.005 m/s, p=0.003) in the diseased coronary artery as compared to the control. Meanwhile we observed that AF patients with higher minimum lumen area (MLA, mm2) (1.65 ± 0.097 vs. 1.11 ± 0.062, p＜0.001) and decreased maximum lesion distorted angle (28.14°± 1.16°vs. 31.95°± 1.23°, p=0.025) compared to the control.Conclusion: Mutated status of anatomical structure and blood flow in the coronary artery of AF patients may enlarge the value of QFR, this may be ascribed to the lower blood flow velocity and decreased maximum lesion distorted angle in AF patients.
Caesarean Delivery Use in Ethiopia: A Spatial and Hierarchical Bayesian Analysis
Authors: TEGEGNE Teketo Kassaw , Chojenta Catherine , Getachew Theodros , Smith Roger , Loxton Deborah
Published: June 2021

Background: Access to emergency obstetric care (EmOC) is very important for reducing maternal mortality. A geographically linked data analysis using population and health facility data is potentially valuable to map caesarean delivery use, and to identify inequalities in service access and provision. Thus, this study aimed to assess the spatial patterns of caesarean delivery use, and to identify associated factors among pregnant women in Ethiopia. Method: A secondary data analysis of the 2016 Ethiopia Demographic and Health Survey linked with the 2014 Ethiopian Service Provision Assessment was conducted. A hierarchical Bayesian analysis was carried out using the SAS MCMC procedure. A spatial analysis was performed to identify the hot spot areas of caesarean delivery use with ArcGIS. Results: Women who had four or more ANC visits were 4.077 (95% Credible Interval (CrI): 1.909, 8.179) times more likely to use caesarean delivery compared to those who had no ANC visits. Pregnant women living in rural areas were 60% less likely to deliver via caesarean section. About 50% of the variability in the rate of caesarean delivery was accounted for by location. The spatial analysis found that Addis Ababa, Dire Dawa and the Harari region had clusters of high caesarean delivery rates. Conclusion: There were significant variations in the use of caesarean delivery services across the different regions of Ethiopia. The findings have important policy implications. The Ethiopian government has to increase the distribution of EmOC facilities and/or to establish a faster transportation system to allow pregnant women to reach EmOC facilities when caesarean delivery is indicated.
SLC17A2 Expression Correlates with Prognosis and Immune Infiltrates in Hepatocellular Carcinoma
Authors: Wang Zhijian , Chen Xuenuo , Jiang Zheng
Published: June 2021

Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with a dismal prognosis according to updated statistics. At present, there are many deficiencies in targeted therapy for liver cancer. The solute carrier family 17 member 2 (SLC17A2) has not been studied in liver cancer, therefore, we evaluate the role of SLC17A2 in HCC by bioinformatics analysis.Methods: The expression level of SLC17A2 in HCC, the clinicopathological data were analyzed based on The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database, the SLC17A2 protein expression was validated by immunohistochemical staining. Besides, the Kaplan–Meier plotter database and receiver operating characteristic (ROC) curve analysis were used to explore the prognostic significance. The biological analyses of SLC17A2 were performed using the gene set enrichment analysis (GSEA). Finally, Tumor Immune Estimation Resource (TIMER) and Gene Expression Profiling Interactive Analysis (GEPIA) databases were used to explore the relationship between immune cell infiltration, immune cell markers and SLC17A2 in HCC.Results: The multivariate Cox regression analysis showed that SLC17A2 expression was low in HCC (P < 0.05), and closely related to the clinical stage of HCC. Besides, SLC17A2 had certain prognostic and diagnostic value in HCC according to ROC curve analysis. Further biological analyses showed that SLC17A2 can regulate fatty acid metabolism, amino acid metabolism and cytochrome P450-related metabolism and is closely related to the peroxisome pathway. Notably, we found that SLC17A2 expression was positively correlated with the infiltration levels of CD4 + T cells, naive CD8+ T cells, naive B cells, negatively associated with the levels of regulatory T cells and closely correlated with most immune cell markers in HCC.Conclusion: SLC17A2 expression is low in HCC and correlates with immune infiltration; thus, it could serve as an independent prognostic factor for HCC.
Trauma and Orthopedics in COVID-19 Pandemic: an Epidemiological Study in a Tertiary Center, South of Iran
Authors: Tahami Seyed Mohammad , Hashemi Seyed Ali , Akbarzadeh Armin , Gerami Mohammad Hadi , Aminian Amir , Mesbahi Amirreza , Zarrabi Amin , Safari Rasool
Published: June 2021

Introduction: The novel COVID-19 disease was presented at first in Wuhan, China, in December 2019. During COVID-19 pandemic, approaching trauma patients, whom could have COVID-19, is a challenging issue required special consideration and healthcare setting.Methods and materials: This retrospective cohort study was conducted at Emtiaz hospital, the main trauma center of the south of Iran, between March 2020 and August 2020 from the beginning of the COVID-19 pandemic. Trauma-related data such as the mechanism of trauma, injury pattern, and surgical intervention procedure of all the suspicious COVID-19 patients were documented. ICU admission and mortality rate were investigated as outcome variables.Results: During six months of the pandemic period, 9248 patients were referred to our referral trauma center, with 222 patients suspicious of having COVID-19 infection. Among sixty-four cases, whom were confirmed to be positive, 33 orthopedic injured patients were observed. The mortality rate of COVID-19 positive cases was 15.6 % (10 patients out of 64) and COVID-19 negative ones was 10.1 % (16 patients out of 158) which was not statistically significant (p.value:0.25). Multivariate analysis of the effect of the baseline and trauma related factors on mortality rate, showed that older age (p. value: 0.001), COVID-19 infection (p. value: 0.033), and surgical procedure (p.value:0.038) are the poor prognostic factors associated with mortality rate.Conclusion: The mortality rate of trauma patients with COVID-19 positive infection was 15.6 % (10 patients). Older age, COVID-19 infection, and surgical procedure were observed as the statistically significant prognostic factors leading to more mortality rate.Level of Evidence: III
miRNAs Associated with Nasopharyngeal Carcinoma: New Prognostic Biomarkers and Therapeutic Targets
Authors: Jiayuan Xu , Xianhui Li , Chuansai Zhu , Lucheng Fang , Wen Wang , Sen Lin
Published: June 2021

Background: Most of the studies included in this analysis highlighted miRNAsrole in the prognosis of nasopharyngeal carcinoma (NPC) patients. Our aim in this bioinformatics study was to synthesize relevant data associated with NPC to identify new prognostic markers. Methods: miRNA and mRNA data related to NPC were downloaded from the Gene Expression Omnibus (GEO) database. A variety of online analytical tools (starBase, TargetScanHuman7.2, Metascape, Cytoscape_v3.6.0, and GEPIA) were used to analyze the downloaded data to identify biomarkers with extremely high sensitivity and further research value. Results: Changes in the expression levels of 13 miRNAs played crucial roles in the overall survival of NPC patients (miR-375 was down-regulated, miR-96-5p, miR-155-5p, miR-320a, miR-378a-3p, miR-15b-5p, miR-21-5p, miR-25-3p, miR-93-5p, miR-493-3p, miR-493-5p, miR-494-3p, and let-7i-5p were up-regulated). Additionally, eight central genes (CDK1, CCNB1, CCNA2, TOP2A, AURKA, MAD2L1, CDC6, and CHEK1) were identified as target genes for further NPC therapy. Conclusions: Our findings further elucidate the underlying relationship between miRNAs and prognosis in NPC. The identified miRNAs are closely related to NPC prognosis and have extremely high research value for future medical treatment.
Association of Comorbidities with Survival in Elderly Patients with Metastatic Bladder Cancer Treated with Chemotherapy
Authors: Kim Ki Hyang
Published: June 2021

IntroductionBladder cancer has a high incidence in elderly patients who have complex comorbidities. There are no data on the association between the comorbidities and overall survival (OS) of elderly patients with metastatic bladder cancer treated with chemotherapy; therefore, we evaluated the comorbidities of these patients.MethodsWe retrospectively reviewed the data of stage IV bladder cancer patients > 65 years of age who underwent chemotherapy at the Busan Paik Hospital between 2008 and 2018. The comorbidities were assessed using the Cumulative Illness Rating Scale-Geriatric.ResultsWe retrospectively reviewed the data of 22 patients. The median age at diagnosis was 71.5 years. The most common comorbidities were genitourinary and hematopoietic diseases. The median OS of all patients was 23.9 months (95% confidence interval: 4.9–42.8). Based on the univariate and multivariate analyses of the prognostic factors associated with OS, no comorbidity categories were found to be associated with OS.ConclusionsAlthough this was a small, retrospective, single-center study, no comorbidity categories were associated with OS. We should not hesitate to treat elderly patients with metastatic bladder cancer, and we should always evaluate their comorbidities in clinical practice.
Cloning, Expression and Biochemical Characterization of a new Carboxypeptidase from Aspergillus Niger
Authors: Song Peng , Xu Wei , Zhang Yang , Wang Fei , Zhou Xiuling , Shi Haiying , feng wei
Published: June 2021

A new serine carboxypeptidase gene, capA, was identified in Aspergillus niger CBS 513.88 by reading genomic information and performing sequence alignment, and then, the gene was cloned and expressed in Pichia pastoris. In a shake-flask, the enzyme activity of the recombinant strain GS115 (pPIC9K-capA) reached 109.7 U/mL. The optimum temperature and pH for enzyme activity were determined to be 45°C and 6.0, respectively. After incubation at 40°C-50°C or at pH 4.0–8.0 for 1 h, the enzyme retained more than 80% or 60% of its initial activity. Mg2+ enhanced the activity of CapA, whereas Cu2+, Fe2+, Co2+ and PMSF inhibited its activity. Among the six substrates tested, five could be hydrolyzed by CapA. CapA had a broad substrate specificity and preferred the hydrophobic amino acids Leu and Lys in the C-terminus of proteins, and CBZ-Phe-Leu was the preferred substrate for CapA. The good thermostability, pH stability and hydrolysis characteristics provide a solid foundation for the application of CapA in the food and biotechnology fields.
Discrimination between Small Earthquakes and Local Quarry Blasts Using Committee Machine
Authors: Lethy Ahmed , Othman Adel , ElGabry Mohamed , Hussein Hesham , El-Qady Gad
Published: June 2021

A combination of multiple discrimination artificial neural networks using different seismic source parameters is suggested using a committee machine. In this work, a committee machine was used to combine supervised and unsupervised artificial neural networks to discriminate between earthquakes and quarry blasts using data from the Egyptian National Seismological Network (ENSN). The unsupervised network is used as a measure of accuracy for the results of the supervised neural network. The unsupervised Self-Organized Map (SOM) and the k-means clustering algorithms are used to estimate support and confidence measures for the results. Meanwhile, the supervised neural network is used to discriminate between earthquakes and explosions. The artificial neural networks are trained using different input parameters which are the P wave spectrum corner frequency (PcF), S wave corner frequency (ScF), and the ratio (Rcf) of PcF to Scf. The combined approach succeeds to discriminate between earthquakes and quarry blasts in Northern Egypt. The method provides the results with a measure of confidence which eliminates false discrimination. The current paper represents an idea to implement artificial intelligence to assist experts in decision-making situations. The committee machine could identify the nature of a particular event, using the aid of several discrimination methods. The proposed committee machine could combine the results of several algorithms and expert opinions to form one single output with a confidence measure.
COVID-19 related healthcare wastes management practices among Bangladeshi medical professionals
Authors: Rahman Md. Mostafizur , Shammi Mashura , Ali Md. Liakath , Khan Abu Sadat Moniruzzaman , Siddique Md. Abu Bakar , Ashadudzaman Md , Bodrud-Doza Md. , Alam G M Mostafizul , Tareq Shafi M
Published: June 2021

Purpose

Amidst the one year of COVID-19 the amount of healthcare waste generation manifolds in Bangladesh. This article aims to rapidly assess the knowledge, attitude, practice, and perception (KAPP) towards COVID-19 related healthcare wastes among Bangladeshi healthcare professionals.
Methods

This research was conducted following a multi-stage methodological approaches to achieve the desired objectives. A total of 300 (= 300) responses were collected from the healthcare professionals, including doctors, nurses, and relevant staff from the public and private medical hospitals and clinics.
Results

It was found that most of the respondents (83.7%) know about the concerning issues of medical wastes and their types. Almost 90.0% (n = 270) respondents agreed with the statement KS3, mentioned as ‘medical waste of COVID-19 patients can be considered as infectious waste’ and they are aware about the potential threat from the waste. It was also found that nearly 76.0% (n = 228) of the respondents know about color coding for the segregation of medical waste. However, interestingly, 68.3% and 43.6% professionals have knowledge about the guidelines of medical waste management. Surprisingly, around 57.0% (n = 171) respondents think that medical waste management adds an extra burden to their work. T-test indicates that demographic characteristics e.g., respondents’ gender, age, occupation/job responsibility, work experience, and level of education, have a significant effect on the safe handling and disposal of biomedical waste.
Conclusion

Despite of having good knowledge about importance of safe handling and management of healthcare wastes Bangladeshi medical professionls have negative attitude and practices in the management of healthcare wastes.
Symbiosis of radio-emitting winds and a jet in a super-Eddington active galactic nucleus
Authors: Yang Xiaolong , Wang Ailing , Yao Su , An Tao , Yang Jun , Ho Luis , Gu Minfeng , Baan Willem , Wang Ran , Liu Xiang , Hong Xiaoyu , Wu Xue-Bing , Zhang Yingkang , Zhao Wei
Published: June 2021

Super-critical accretion is the most powerful episode in nursing the black hole growth and works in several types of objects. Given that the inverse correlation between radio loudness and Eddington ratio, the super-Eddington active galactic nuclei (AGNs) hold the extremely radio-quiet end of AGNs. Regarding the existence of jet in super-Eddington or radio-quiet AGNs, it’s still unclear. Years of studies indicate nearly all types of super-Eddington accreting systems can launch a jet with one exception: no clear evidence to show jet in super-Eddington AGNs. Observations and theoretical works suggest that super-Eddington accretion can drive high-speed wind-like outflows, therefore produce radio emission through synchrotron (shocked wind) and bremsstrahlung mechanisms. However, such a radio-emitting wind has not been observed in super-Eddington systems except for the Galactic micro-quasar SS 433. In principle, high resolution very long baseline interferometry (VLBI) observation can directly map the inner structure of super-Eddington AGNs. Here, we report the discovery of the coupling of jet and radio-emitting winds in a nearby super-Eddington AGN, I Zw1. Its parsec-scale jet exhibits a wiggling, we interpret this as a jet precession. All the features make IZw1 act as a scaled-up version of SS 433. The observations favour that jet can be launched in extremely radio-quiet AGNs and ubiquitous in super-Eddington accreting systems. The jet wiggling or precession can produce a large aperture-angle shock, which emphasises the jet’s contribution to gas feedback. As the jet precession was also discovered in other super-Eddington systems such as SS 433 and V404 Cygni, it is possible that there is a correlation with each other.
Prognosis and functional role of EIF4G1 in lung squamous cell carcinoma
Authors: Bai Baoxin , Wang Lingwei , Huang Zhiyuan , Zhang Zhiwen , Lu Ying , Xu Zengguang , Liu Yali
Published: June 2021

Purpose

To study the functional role and prognosis of EIF4G1 in lung squamous cell carcinoma (LSCC).
Methods

The clinical relevance of EIF4G1 in LSCC was investigated following detection of the expression levels of EIF4G1 by immunohistochemical staining (IHC). The expression levels of EIF4G1, AKT2, p-AKT, mTOR, cyclin D1 and β-actin were detected by western blot analysis. The cell proliferation and colony formation assays were used to detect the cell proliferative ability; flow-cytometry was used to assess the cell cycle; an invasion assay was used to detect cell invasive ability and the real-time quantitative polymerase chain reaction (Q-PCR) assay was used to assess the expression levels of EIF4G1 and β-actin. The role of EIF4G1 was verified by xenograft models. These experimental methods were employed to assess the functional role of EIF4G1 in LSCC pathogenesis.
Results

EIF4G1 was overexpressed in LSCC tumor tissues (P < 0.05) compared with the corresponding expression noted in paired adjacent tissues and cells. The expression levels of EIF4G1 were dependent on age (P = 0.002) and clinical stage (I vs II vs III + IV) (P < 0.001). High expression of EIF4G1 (P = 0.008, HR = 2.277, 95% CI = 1.250–4.145) could be used to predict the overall survival of LSCC patients as determined by the Cox’s proportional hazard model. High expression of EIF4G1 exhibited a lower survival (LogRank = 7.167, P = 0.007) in LSCC. Downregulation of EIF4G1 significantly inhibited LSCC proliferation, invasion and cell cycle progression.
Conclusion

EIF4G1 promotes LSCC cell proliferation and may represent an indicator of prognosis in LSCC.
Dysphagia Therapy in Adults with a Tracheostomy: A Scoping Review Protocol
Authors: Kadri Waiza , Halfpenny Rhiannon , Whiten Breege , Smith Christina , Mulkerrin Siofra
Published: June 2021

Background

Swallowing impairment (dysphagia) and tracheostomy coexist. Research in this area has often provided an overview of dysphagia management as a whole, but there is limited information pertaining to specific dysphagia therapy in the tracheostomy population. The aim of this scoping review is to provide detailed exploration of the literature with regards to dysphagia therapeutic interventions in adults with a tracheostomy. The scoping review will describe current evidence and thus facilitate future discussions to guide clinical practice.
Methods

A scoping review using the Joanna Briggs Institute and Preferred Reporting Items for Systematic Reviews guideline will be used. Ten electronic databases from inception to July 2021and grey literature will be searched. From identified texts forward and backward citation chasing will be completed. Data extraction will compose of population demographics, aetiology and dysphagia therapy (type, design, dose and intensity). Number of citations and papers included into the scoping review will be presented visually.
Discussion

The scoping review aims to expand upon the existing literature in this field. A detailed description of the evidence is required to facilitate clinical discussions and develop therapeutic protocols in a tracheostomised population. The results of this scoping review will support future research in dysphagia therapy and provide the basis for development of best practice guidelines.
A method of joining piecewise functions to produce continuous functions of difficult data
Authors: Orszulik Stefan T
Published: June 2021

This article describes a method of modelling data that involves splitting the curve into two (or more) and creating separate piecewise functions for each part; these functions are then concatenated via a linking function to create one overall continuous function that better describes the original data than is otherwise achievable. The linking function is able to do this by separating the original two (or more) subfunctions so that they are each active in only the relevant portion of the overall curve without the use of dummy variables. The final result is a continuous function in which it is straightforward to smooth the transition at the knot between the piecewise subfunctions. In addition, the piecewise subfunctions do not need to align at the knot since the degree of smoothing is very readily controlled. All types of functions may be concatenated so that the method is flexible and relatively simple to apply.
Training New Research Trainers: an Open Science and Medical Education Innovative Experience
Authors: Yabrude Angela Theresa Zuffo , Campos Letícia Nunes , Medeiros Samantha Sartore Duque Estrada , Custódio Clarissa Garcia , de Abreu Richardson Chaves , de Freitas Sarah Laís Silva , Cunha Moises da Costa , Hoshino Hillary Sayuri Ramires , Silva Barbara de Almeida Sena da , Ribeiro Lucas Loiola Ponte Albuquerque , Camargo Cristina Pires
Published: June 2021

Introduction: Open science is a valuable path to boost the global potential of scientific research by removing barriers for producing, disseminating, and putting science into practice, with the spirit of collaboration, inclusivity and focusing on communities’ rising demands. Open science principles instigate the management of scientific knowledge and the enhancement of abilities such as research, project management, team-building skills, and numerous others, which are essential for medical practice according to international recommendations, although still underexplored by medical schools.Methods: Open science, peer education, student leadership and developing of scientific skills were cornerstones to promote the Training New Research Trainers, the first edition of a national Brazilian student-led online workshop aiming to capacitate medical students in such targeted competencies and abilities through active teaching and learning methodologies.Results: Despite the challenges of online format, as impairment in some dynamics and assessment methods, it improved the access to the event from all Brazilian regions, totaling 409 submissions. Thus, it was necessary to have a previous selection of participants and adjustments in the workshop to assist twice the expected attendants.Discussion and Conclusions: Training New Research Trainers surpassed the national distribution inequalities of research opportunities and resources; mirrored open science bases in terms of access, education and methodology; and showed to be a promising opportunity for students to be protagonists of their learning process and to contribute to future changes in their reality, especially regarding the public health landscape. Improvements and consolidation of the workshop protocol and its expansion through national and international partnerships are the following goals.
Functionally prioritised whole-genome sequence variants improve the accuracy ofgenomic prediction for heat tolerance
Authors: Cheruiyot Evans K. , Haile-Mariam Mekonnen , Cocks Benjamin G. , MacLeod Iona M. , Mrode Raphael , Pryce Jennie E.
Published: June 2021

Background

Heat tolerance is a trait of economic importance in the context of warm climates and the effects of global warming on livestock, production, reproduction, health, and well-being. It is desirable to improve the prediction accuracy for heat tolerance to help accelerate the genetic gain for this trait. This study investigated the improvement in prediction accuracy for heat tolerance when selected sets of sequence variants from a large genome-wide association study (GWAS) were incorporated into a standard 50k SNP panel used by the industry.
Methods

Over 40,000 dairy cattle (Holsteins, Jersey, and crossbreds) with genotype and phenotype data were analysed. The phenotypes used to measure an individual’s heat tolerance were defined as the rate of milk production decline (slope traits for the yield of milk, fat, and protein) with a rising temperature-humidity index. We used Holstein and Jersey cows to select sequence variants linked to heat tolerance based on GWAS. We then investigated the accuracy of prediction when sets of these pre-selected sequence variants were added to the 50k industry SNP array used routinely for genomic evaluations in Australia. We used a bull reference set to develop the genomic prediction equations and then validated them in an independent set of Holsteins, Jersey, and crossbred cows. The genomic prediction analyses were performed using BayesR and BayesRC methods.
Results

The accuracy of genomic prediction for heat tolerance improved by up to 7%, 5%, and 10% in Holsteins, Jersey, and crossbred cows, respectively, when sets of selected sequence markers from Holsteins (i.e., single-breed QTL discovery set) were added to the 50k industry SNP panel. Using pre-selected sequence variants identified based on a combined set of Holstein and Jersey cows in a multi-breed QTL discovery, a set of 6,132 to 6,422 SNPs generally improved accuracy, especially in the Jersey validation set. Combining Holstein and Jersey bulls (multi-breed) in the reference set improved prediction accuracy compared to using only Holstein bulls in the reference set.
Conclusion

Informative sequence markers can be prioritised to improve the genetic prediction of heat tolerance in different breeds, and these variants, in addition to providing biological insight, have direct application in the development of customized SNP arrays or can be utilised via imputation into current SNP sets.
Binding Affinities of Sanggenon Derivatives as PTP1B Inhibitors; Using Molecular Dynamics and Free Energy Calculations
Authors: KOCAKAYA Safak OZHAN
Published: June 2021

Recently, protein tyrosine phosphatase 1B (PTP1B) inhibitors have become the frontier as possible targeting for anti-cancer and antidiabetic drugs. The contemporary observe represents a pc assisted version to investigate the importance of precise residues within the binding web site of PTP1B with numerous Sanggenon derivatives remoted from nature. Molecular dynamics (MD) simulations were performed to estimate the dynamics of the complexes, and absolute binding unfastened energies have been calculated with exclusive additives, and carried out through the usage of the Molecular Mechanics-Poisson-Boltzmann floor region (MM-PB/SA) and Generalized Born surface vicinity (MM-GB/SA) strategies. The effects show that the expected free energies of the complexes are normally constant with the available experimental statistics. MM/GBSA free energy decomposition analysis shows that the residues Asp29, Arg24, Met258, and , Arg254 in the second active site in PTP1B are crucial for the excessive selectivity of the inhibitors.
A MICROFLUIDIC CHIP FOR PULMONARY ARTERIAL HYPERTENSION
Authors: Wojciak-Stothard Beata , Ainscough Alexander , Smith Timothy , Rhodes Christopher , Fellows Adam , Howard Luke , Wharton John , Wilkins Martin , Edel Joshua
Published: June 2021

Pulmonary arterial hypertension (PAH) is an unmet clinical need. The lack of a disease model representative of the human condition is a key obstacle to the development of new treatments. Here we present a model of PAH, based on a biomimetic pulmonary artery (PA)-on-a-chip, that permits the study of the molecular and functional changes in human pulmonary vascular endothelial and smooth muscle cells in response to triggers of the disease and their response to drugs. We combine natural or induced BMPR2 dysfunction with hypoxia in vascular endothelial cells to trigger smooth muscle activation and proliferation and relate accompanying transcriptomic changes in affected cells to functional effects. Changes in gene expression consistent with observations made in genomic and biochemical studies of the human disease enable insights into underlying disease pathways and mechanisms of drug response. The model offers a novel, promising and more easily accessible approach for researchers to study pulmonary vascular remodelling and advance drug development in PAH.
ADHESIVE COATING VALUE BASED ON THE MAIN INGREDIENT OF SHIP PAINT
Authors:   Department of Engineering and Marine Science, University of Hang Tuah, Surabaya – Indonesia, Suwasono Bagiyo , Putra I Kadek Agus Sudama , Kristiyono Tri Agung , Azhar Ali
Published: June 2021

Coatings are important instruments in inhibiting the corrosion rate. Field facts in various Indonesian shipping industries show that the choice of organic materials as coating for ship paint uses epoxy, vinyl and polyurethane. Therefore an experimental study is needed on the adhesion ability of paint as a coating for ship armor with these three types of organic materials. The preparation of steel specimens with type ASTM A36 is carried out by blasting, visual inspection standard ISO 8501-1, and roughness test standard ISO 8503-4. Painting of specimens by measuring the thickness of the paint in the wet conditions ASTM D4414 standard and ASTM D4138 standard dry conditions. Treatment of specimens in two conditions, are: tropichal weather condition and salt spray conditon. Observation of specimens by scanning electron microscope and adhesion test standard ASTM D4541-02. The final result shows that the best adhesion ability of the main paint coating in tropical weather conditions was a polyurethane coating with no blister characteristics, but there are fractures on the surface of the material. While the main material for the best coating in salt spray conditions was epoxy coating with characteristics that are resistant to blisters and blends with the surface of the material.
Intellectual Property Rights and Monopoly in the Perspective of Islamic Jurisprudence
Authors: Meirison Meirison , Nazar Zerly
Published: June 2021

This paper aims to reveal fiqh's review of Intellectual Property Rights (IPR) and their relationship with monopolies that can harm humankind. There are two opinions in contemporary fiqh regarding IPR; first, Ahmad al-Ḥujjī al-Kurdī, which states that IPR as part of worship, should not be hidden and should not be monopolized and exploited by anyone. Second, Muṣṭafā Zarqā, Muḥammad Fatḥī al-Duraynī, Muḥammad Sa'īd Ramaḍān al-Būṭī who agree with the protection of IPR. Through literature study and descriptive analysis approach, this paper concludes that if intellectual property rights cause harm to society and the state, especially in the exploitation of material rights, then it has created a monopoly that is detrimental and prohibited. Every country has different policies to protect IPR when it does not harm the community and the state.
Justice Ontology; A Study of ‘Umar Ibn Al-Khaṭṭāb’s Ijtihād
Authors: Mansur Ahsan Dawi , Murtiningsih Siti
Published: June 2021

The paper was conducted to discover the nature of justice in the view of 'Umar Ibn Al-Khaṭṭāb and to reveal his ijtihād from the point of view of a philosophical theory of justice. This research includes philosophical research that is historical-factual about a character with the type of library research then analyzes and presents it in a descriptive form. This paper finds that the essence of justice in the view of 'Umar Ibn Al-Khaṭṭāb is acceptable behavior that is animated by the principle of equality. 'Umar Ibn Al-Khaṭṭāb has applied the principle of equality before the law. He treats reason and revelation in harmony and balance in his ijtihād. 'Umar Ibn Al-Khaṭṭāb drew inspiration from the intellect that Allah had given him by capturing universal values brought by the Koran, such as justice and equality, which are valid forever. This research contributes to the flexibility of 'Umar Ibn Al-Khaṭṭāb in ijtihād, which is imbued with the principle of equality.
Implementation of Ta'widh (Compensation) for Default Customers at KPR Platinum iB in the Perspective of Fatwa DSN-MUI No.129 / DSN-MUI / VII / 2019 at Bank BTN KCPS Karawaci
Authors: Rachman Abdul , Aini Fikriana
Published: June 2021

Purpose - This study aims to determine the implementation of ta'widh (compensation) for default customers on KPR Platinum iB in the perspective of Fatwa DSN-MUI No.129 / DSN-MUI / VII / 2019.Method - This study uses a qualitative analysis method with data collection techniques through observation, in-depth interviews and documentation. Purposive sampling technique is used by selecting sources who are considered the most knowledgeable related to the research topic.Result - The results of this study indicate that the implementation of ta'widh for default customers on the KPR Platinum iB is in accordance with the DSN-MUI Fatwa No.129 / DSN-MUI / VII / 2019. But in practice, there are several notes. The implementation of ta'widh and ta'zir at Bank BTN KCPS Karawaci is different. Ta'widh is charged to customers who experience delays in paying their obligations for more than 180 days and the ta'widh funds obtained will be recorded as Bank revenue. Ta'zir will be charged to customers who do not pay installments according to the due date and the ta'zir funds obtained will be recorded as non-halal income.Implication - This research can be used as a reference in measuring the conformity between the DNS-MUI Fatwa No. 129 / DSN-MUI / VII / 2019 with its implementation in the practice of financing in Islamic banks.Originality - This research focuses on analyzingimplementation of ta'widh (compensation) for default customers on KPR Platinum iB in the perspective of Fatwa DSN-MUI No.129 / DSN-MUI / VII / 2019..
Customer Perceptions of Murabahah Financing on MSMEs
Authors: Al Mustaqim Muflih Khallab , Djakfar Muhammad , Munir Misbahul
Published: June 2021

Purpose - This study aims to examines the concept and implementation strategy of murabahah financing in the development of MSMEs and customer perceptions of murabahah financing at Bank BRI Syariah Jambi Branch Office.Method - This research uses a qualitative approach with a type of case study. The research data were obtained by conducting in-depth interviews, observation and documentation. MethodMiles and Huberman were used as data analysis techniques by way of data reduction, data presentation and drawing conclusions / verification.Result - Murabahah financing at BRI Syariah Bank Jambi Branch Office using murabahah with installments (bitsaman ajil). The next concept is to combine the wakalah and murabahah contracts. The strategy chosen in an effort to increase murabahah financing is to implement two strategies simultaneously, namely the internal strategy and the external strategy. Meanwhile, the perceptions of murabahah financing customers on the development of MSMEs are generally satisfied with the systems, regulations and services provided. However, customers' understanding of the concept of Islamic banking is still minimal.Implication - Optimizing the strategy for increasing financing and disseminating the understanding of the Islamic banking concept to customers and the general public at large.Originality- This study aims to determine the perceptions of Islamic bank customers about murabahah financing in Jambi City.
Analysis Of The Effect Of Islamic Product Attributes, Servicescape, And Interpersonal Communications On Customer Satisfaction Bank BTN Syariah KCPS Ngaliyan
Authors: Nurudin Nurudin , Anwar Khoirul , Hidayaturrosyida Hidayaturrosyida
Published: June 2021

Purpose - This study aims to determine the effect of Islamic product attributes, service scape, interpersonal communication on customer satisfaction at Bank BTN Syariah KCPS Ngaliyan.Method - The method used in this research is quantitative method, where this method is carried out by distributing questionnaires to BTN Syariah KCPS Ngaliyan customers. Samples were taken as many as 100 respondents with incidental sampling technique.Result - The results show that the variable attributes of Islamic products, servicescape, and interpersonal communication have a positive and significant effect on customer satisfaction of BTN Syariah KCPS Ngaliyan.Implication - This research can be used for references related to matters that affect customer satisfaction.Originality- This study analyzes the variable attributes of Islamic products, servicescape, and interpersonal communication on customer satisfaction.
The Effect of Promotion on Interest in Opening an Account at Bank Muamalat, Palu Branch
Authors: Dolita Gita , Malarangan Hilal , Malkan Malkan
Published: June 2021

Purpose - The purpose of this study was to determine whether promotion has an effect on the interest of Islamic banking students in opening an account at the hammer branch of the muamalat bank and to find out how significant the effect of promotion is on student interest in opening an account at the hammer branch of the muamalat bank.Method - This study uses primary data, namely a questionnaire that uses a Likert scale as a calculation scale. The sample of this study was 485 students of the Faculty of Economics and Islamic Business IAIN Palu, Department of Islamic Banking from class 2016 to class 2018. To analyze the data, the authors used multiple linear regression methods and SPSS version 21. Result - Research result shows that the magnitude of the influence of the variable (X) on the variable (Y) is 0.388 or 38.8%. These results can provide an illustration that respondents (students) view that promotion can influence student interest in opening an account at a muamalat bank and promotion has a significant effect on student interest in opening an account at a muamalat bank. it can be seen that the promotion variable (X) has a value of tcount 3.783 t table 1.663 and has a significant value (sig) of 0.000 in the coefficients table with a value of α (significant level) 0.05. This means 0.000 0.05.Implications - This study is only limited to using data from several students in one university. Originality-. The difference with previous research is in the location and object under study.
Analysis of The Influence of Audit Committee, Sharia Supervisory Board, and Islamic Work Ethic on The Quality of Sharia Bank Financial Statements in Indonesia
Authors: Budiyono Iwan , Sabilla Chansera Kista
Published: June 2021

Purpose - This study aims to analyze the influence of audit committees, sharia supervisory boards, and Islamic work ethic on the quality of islamic bank financial statements in Indonesia.Method - The method in this study used Multiple Linear Regression Analysis with SPSS software tools.Result - Based on the results of this research, simultaneously the audit committee, sharia supervisory board, and Islamic work ethic have a significant influence on the quality of islamic bank financial statements in Indonesia. Meanwhile, in part, the audit committee and islamic work ethic have no significant effect on the quality of islamic bank financial statements in Indonesia. SSB partially affects the quality of islamic bank financial statements in Indonesia.Implication - This study uses the data from Islamic bank financial statement in Indonesia, audit committees, sharia supervisory boards, Islamic work ethic.Originality - The data was taken with the dissemination of questionnaires distributed to 30 respondents. The respondents were a reflection of the members of the audit committee and SSB who were qualified as students of sharia banking polytechnic state of semarang who had received islamic bank audit courses.
Creation of Komsomol Cafés in 1960s
Authors:   Kazan State University of Architecture and Engineering, Bureeva E. V.
Published: June 2021

This article, using extensive archival material, examines the history of the emergence of youth cafés, provides an analysis of the preconditions and historical conditions in which they were created, and highlights the problems that they had to overcome on their way. During the 1960s youth cafés was created throughout the country on the initiative of Komsomol members. There were places where one could have an interesting and fun time listening to jazz over a cup of coffee or a glass of wine, dancing a popular twist, meeting poets and musicians and artists, or just going an impromptu stage to read poems. The youth café became a symbol of the 1960s. The feeling of freedom was first felt by young people who began to actively explore Western culture and lifestyle. Harsh administrative measures and punishments proved to be ineffective. This is how the idea of creating the first youth club, corresponding to the interests and demands of young people, arose, but under the supervision of an “elder brother” in the form of the Komsomol. Urban young boys and girls were attracted by the democratic atmosphere of the café, which the sixtiers would later write about more than once. In the mid-1960s this interesting experience was relocated to the countryside, but this was less successful. Even in large cities, not many cafés survived until the mid-1970s, faced with enough problems.
Interpreting Eisenstein’s Ivan the Terrible
Authors:   University of Richmond, Brandenberger D.
Published: June 2021

This critical analysis of Joan Neuberger’s book This Thing of Darkness (Cornell University Press, 2019) hails the monograph for its exhaustive research and thorough analysis. Eisenstein stands out in the pages of This Thing of Darkness as the quintessential non-conformist — an exception to everything we know about Soviet subjectivity. Neuberger argues that the question of whether Eisenstein was pro-Soviet or anti-Soviet is effectively a reductionist dead end. Eisenstein, she suggests, was an exception — someone who defied categorization, whether by his cinematographer contemporaries or by Stalin himself, for that matter. The article contends that Neuberger’s reading of Eisenstein as an imaginative, stubborn, risk-taking and subversive director challenges recent scholarship on the restrictive nature of Stalinist subjectivity. The author also investigates Neuberger’s contention that Stalin banned the second part of Ivan the Terrible in part because of the film’s homoeroticism by reexamining the fragmentary historical record. In so far as there is no reason to think that Stalin would have hesitated to articulate to Zhdanov or to Eisenstein and Cherkasov any specific objections he had to the film’s homoeroticism, the author suspects that the best explanation for the dictator’s banning of the film remains the historical license that Eisenstein took with the official Stalinist line on the terrible tsar.
Cyanobacterial biomass: a striking factor to decrease polyaluminium chloride (PACl) coagulation efficiency during a successive bloom
Authors: Song Weijun , Zeng Jie , Li Xi , Xie Yu , Wu Xunfang
Published: June 2021

Occurrence of cyanobacterial blooms in source waters challenges water treatment processes. During a successive bloom, typical characteristics of elevated cell-density and pH were observed from development to maintenance stage. However, studies about their influences on the coagulation process have been limited. Here, PACl coagulation experiments were conducted to investigate Microcystis removal with varied pH and cell-density. Results showed that PACl coagulation alone was sufficient to remove Microcystis with low cell-density (105–106 cells mL−1), since an elevated pH value (8.5–9.5) can promote PACl coagulation, possibly ascribed to sweeping cells via neutral gelatinous precipitate of alum. Nevertheless, elevated cyanobacterial biomass was a striking factor in decreasing Microcystis removal (80%–100%) by PACl coagulation, since its inhibitory effects on the coagulation process could not be offset by in situ elevated pH value. Chlorination-assisted (1 mg L−1) coagulation was recommended to treat cyanobacteria-laden source waters with high cell-density of >107 cells mL−1, as it promoted cyanobacterial removal and achieved the highest removal ratio of DOC and turbidity among these treatments. These findings will provide an important reference for water supplies to choose the proper water treatment process to treat cyanobacteria-laden source waters during a successive bloom.