bluuebunny/crossref_metadata_2025 huggingface dataset:
Steric Exclusion Chromatography for Purification of Biomolecules—A Review
Authors: Labisch Jennifer J. , Wiese G. Philip , Pflanz Karl
Published: March 2023

Steric exclusion chromatography (SXC) is a purification method that is based on steric exclusion effects from the surface of the target and a hydrophilic stationary phase after the addition of polyethylene glycol (PEG), which leads to an association of the target with the stationary phase without direct binding, such as covalent, electrostatic, and hydrophilic/hydrophobic interactions. The gentle nature of the method has led to an increased focus on sensitive targets such as enveloped viruses with potential for other sensitive entities, e.g., extracellular vesicles and virus-like particles. SXC is related to PEG-mediated protein precipitation, but investigation of further process parameters was crucial to gain a better understanding of the SXC method. After explaining mechanistic fundamentals and their discovery, this review summarizes the findings on SXC from its first reference 11 years ago until today. Different applications of SXC are presented, demonstrating that the method can be used for a wide variety of targets and achieves high recovery rates and impurity removal. Further, critical process parameters for successful process implementation are discussed, including technical requirements, buffer composition, and scalability.
Rilpivirine and Dolutegravir Simultaneously Measured via RP-HPLC-PDA with Box–Behnken Design Application: A Study of Forced Degradation under Various Conditions
Authors: Wahab Shadma , Khalid Mohammad , Ahmad Sarfaraz , Sweilam Sherouk Hussein
Published: March 2023

Simultaneous estimation of rilpivirine (RLVN) and dolutegravir (DTGR) in bulk and tablet dosage forms via RP-HPLC-PDA with a Box–Behnken design (BBD) has been performed in this study to develop a fast, precise, timely and cost-saving method for estimating RLVN and DTGR in bulk and tablet dosage forms. The chromatographic conditions were optimized via the BBD, and the developed method was validated according to the ICH guidelines. Additionally, forced degradation studies were also conducted. RLVN and DTGR peaks were observed at retention times of 2.167 and 2.716 min, respectively, in a 6-min runtime. Kromasil 150 mm× 4.6 mm, 5 µm C 18 column was used. The flow rate of the mobile phase was 1.0 mL/min at a temperature of 30 °C. The mobile phase composition was a 0.1% OPA buffer and acetonitrile (ACN) in a 60:40 ratio. Elutes were measured at 260 nm (max) after being injected in a sample volume of 10 µL. The assay result of the marketed tablet was 99.19% and 99.09% for RLVN and DTGR, respectively. The results of forced degradation studies in different chemical environments conditions such as acid, base, dry heat, photo-stability, neutral, and oxidation conditions were observed for RLVN (5.96, 4.79, 3.27, 2.36, 0.99, and 4.35 in percentage degradation) and DTGR (5.67, 4.44, 4.09, 1.81, 0.43, and 4.28 in percentage degradation). The results of the validation parameters were within an acceptable range. The newly formed RP-HPLC-PDA method is novel, fast, precise, time-saving, and cost-effective.
Yield and Chemical Composition of Ginger Essential Oils as Affected by Inter-Varietal Variation and Drying Treatments of Rhizome
Authors: Kamal Ghulam Mustafa , Nazi Nafia , Sabir Asma , Saqib Muhammad , Zhang Xu , Jiang Bin , Khan Jallat , Noreen Ayesha , Uddin Jalal , Murtaza Shahzad
Published: March 2023

Ginger (Zingiber officinale Rosc; Zingiberaceae family) is an herb commonly used as a spice and remedy for a broad spectrum of diseases. The essential oil extracted from ginger is an effective antioxidant, anti-inflammatory, and antifungal agent. The present study has investigated the variations in yield and chemical composition of essential oils of two cultivars (Chinese and Thailand) of ginger locally available in Pakistan. Two different drying pretreatments were employed to observe the changes in compositional variations of the essential oils of ginger. The essential oil extracted from fresh, oven-dried, and sun-dried samples of two different cultivars of ginger was analyzed using gas chromatography-mass spectrometry (GC-MS). The essential oil yield was found to be highest for the sun-dried sample of each variety. The major compounds (>4%) overall in the essential oil of fresh, oven-dried, and sun-dried ginger samples from Thailand origin were camphene, 3-carene, o-cymene, caryophyllene, α-curcumene, sabinol trans, citral, and santalol. Major compounds overall in the essential oil of fresh, oven-dried, and sun-dried ginger samples of Chinese origin were α-pinene, Camphene, limonene, longicyclene, copaene, longifolene, β-sesquiphellandrene, alloaromadendrene, γ-muurolene, α-curcumene, α-farnesene, and citral. The inter-varietal variations and pretreatment methods considerably affected yield and chemical composition. Cluster analysis was performed to validate the results further. Significantly varying compounds responsible for the significant variation among varieties and treatments of the ginger were identifies by using the heat map. There was clear differentiation among Chinese and Thailand varieties due to the variation in the concentrations of the volatile compounds. The results obtained can be helpful for the ginger growers and end users to choose the ginger variety and the way of use that is more beneficial.
MRI of Implantation Sites Using Parallel Transmission of an Optimized Radiofrequency Excitation Vector
Authors: Berangi Mostafa , Kuehne Andre , Waiczies Helmar , Niendorf Thoralf
Published: March 2023

Postoperative care of orthopedic implants is aided by imaging to assess the healing process and the implant status. MRI of implantation sites might be compromised by radiofrequency (RF) heating and RF transmission field (B1+) inhomogeneities induced by electrically conducting implants. This study examines the applicability of safe and B1+-distortion-free MRI of implantation sites using optimized parallel RF field transmission (pTx) based on a multi-objective genetic algorithm (GA). Electromagnetic field simulations were performed for eight eight-channel RF array configurations (f = 297.2 MHz), and the most efficient array was manufactured for phantom experiments at 7.0 T. Circular polarization (CP) and orthogonal projection (OP) algorithms were applied for benchmarking the GA-based shimming. B1+ mapping and MR thermometry and imaging were performed using phantoms mimicking muscle containing conductive implants. The local SAR10g of the entire phantom in GA was 12% and 43.8% less than the CP and OP, respectively. Experimental temperature mapping using the CP yielded ΔT = 2.5–3.0 K, whereas the GA induced no extra heating. GA-based shimming eliminated B1+ artefacts at implantation sites and enabled uniform gradient-echo MRI. To conclude, parallel RF transmission with GA-based excitation vectors provides a technical foundation en route to safe and B1+-distortion-free MRI of implantation sites.
Viral Vectors in Gene Therapy: Where Do We Stand in 2023?
Authors: Lundstrom Kenneth
Published: March 2023

Viral vectors have been used for a broad spectrum of gene therapy for both acute and chronic diseases. In the context of cancer gene therapy, viral vectors expressing anti-tumor, toxic, suicide and immunostimulatory genes, such as cytokines and chemokines, have been applied. Oncolytic viruses, which specifically replicate in and kill tumor cells, have provided tumor eradication, and even cure of cancers in animal models. In a broader meaning, vaccine development against infectious diseases and various cancers has been considered as a type of gene therapy. Especially in the case of COVID-19 vaccines, adenovirus-based vaccines such as ChAdOx1 nCoV-19 and Ad26.COV2.S have demonstrated excellent safety and vaccine efficacy in clinical trials, leading to Emergency Use Authorization in many countries. Viral vectors have shown great promise in the treatment of chronic diseases such as severe combined immunodeficiency (SCID), muscular dystrophy, hemophilia, β-thalassemia, and sickle cell disease (SCD). Proof-of-concept has been established in preclinical studies in various animal models. Clinical gene therapy trials have confirmed good safety, tolerability, and therapeutic efficacy. Viral-based drugs have been approved for cancer, hematological, metabolic, neurological, and ophthalmological diseases as well as for vaccines. For example, the adenovirus-based drug Gendicine® for non-small-cell lung cancer, the reovirus-based drug Reolysin® for ovarian cancer, the oncolytic HSV T-VEC for melanoma, lentivirus-based treatment of ADA-SCID disease, and the rhabdovirus-based vaccine Ervebo against Ebola virus disease have been approved for human use.
Monitoring of Diabetes Mellitus Using the Flash Glucose Monitoring System: The Owners’ Point of View
Authors: Re Mariachiara , Del Baldo Francesca , Tardo Antonio Maria , Fracassi Federico
Published: March 2023

The flash glucose monitoring system (FGMS) has recently become one of the most common monitoring methods in dogs and cats with diabetes mellitus. The aim of this study was to evaluate the impact of FGMS on the quality of life of diabetic pet owners (DPOs). Fifty DPOs were asked to answer a 30-question survey. More than 80% of DPOs considered FGMS easier to use and less stressful and painful for the animal compared to blood glucose curves (BGCs). Overall, 92% of DPOs reported that their pet had better diabetes control since using FGMS. The most challenging aspects of using the FGMS were ensuring proper sensor fixation during the wearing period (47%), preventing premature detachment (40%), and purchasing the sensor (34%). Moreover, 36% of DPOs reported that the device cost was difficult to afford in the long term. Comparing dogs and cats, a significantly higher number of dogs’ owners found the FGMS to be well-tolerated (79% vs. 40%), less invasive than BGCs (79% vs. 43%), and easier to maintain in situ (76% vs. 43%). In conclusion, FGMS is considered by DPOs to be easy to use and less stressful compared to BGCs, while enabling better glycemic control. Nevertheless, the costs related to its long-term use might be difficult to sustain.
Central and Peripheral Ocular High-Order Aberrations and Their Relationship with Accommodation and Refractive Error: A Review
Authors: Gomes Jessica , Sapkota Kishor , Franco Sandra
Published: March 2023

High-order aberrations (HOAs) are optical defects that degrade the image quality. They change with factors such as pupil diameter, age, and accommodation. The changes in optical aberrations during accommodation are mainly due to lens shape and position changes. Primary spherical aberration (Z(4.0)) is closely related to accommodation and some studies suggested that it plays an important role in the control of accommodation. Furthermore, central and peripheral HOAs vary with refractive error and seem to influence eye growth and the onset and progression of myopia. The variations of central and peripheral HOAs during accommodation also appear to be different depending on the refractive error. Central and peripheral high-order aberrations are closely related to accommodation and influence the accuracy of the accommodative response and the progression of refractive errors, especially myopia.
Educación financiera y sus características en Soacha
Authors: Villamil Escobar Leslie Carolina , Ramirez Gonzalez Yuly Paola
Published: March 2023

El presente artículo plasma los factores sociales, económicos y culturales que influyen en los habitantes del municipio de Soacha al uso de un sistema financiero formal para la realización de sus transacciones financieras o económicas, o también llamado “bancarización” y los cuales impiden tener una buena educación financiera. El carácter cuantitativo de la investigación en este proyecto permitió aplicar la herramienta de recolección de información; a una muestra de 208 habitantes de la comuna I del municipio Soacha. Esto llevó a los investigadores a demostrar las barreras de la educación financiera y cómo influye en las decisiones económicas de la población, y lo cual afecta indirectamente su crecimiento económico y productivo. Dentro de los principales hallazgos se evidencio que; los hábitos financieros personales se inclinan hacia la financiación a corto plazo; las personas normalmente no tienen ahorros formales a largo plazo. En cambio, tienden a juntar dinero en cadenas o fondos familiares. Igualmente, la mayoría de las personas no tienen mucho dinero ahorrado por más de un año a la vez. Así mismo, las personas de las comunas I tienen una tendencia cultural a no ahorrar dinero de manera formal. Por lo general, pasan su tiempo viviendo su vida cotidiana de la manera que dicta la cultura conocida popularmente, “Al diario”,  esto se debe a que los hogares de las personas a menudo se convierten en centros de consumo masivo, con poco o ningún ingreso generado.
PARTICULARS OF BALLASTING IN FRESH WATER NORTH AMERIKAN PORTS
Authors: Borodin O. , Bidenko S. , Borodin E.
Published: March 2023

The particulars of ballasting in fresh water North American ports have been considered. The problems have

been shown as well as possible ways for resolve
RESEARCH ON CHOOSING THE BEST GAS FOR THE FLETTNER BALLOON, AN UNCONVENTIONAL POWER GENERATOR ENERGY DEVICE
Authors: VASILESCU M.-V. , Epikhin Alexey Ivanovich
Published: March 2023

In the last 30 years, the degree of pollution has been continuously increasing and the chemical structure of the

atmosphere has changed due to large amounts of polluting emissions such as N0X, S0X, C02 and other particles

resulting from combustion, which lead to the destruction of the ozone layer, climate change, greenhouse effect

or acid rain. Because the price of oil is continuously increasing, the atmosphere is degrading due to emissions

of exhaust gases and the general degree o f pollution of the Earth is increasing day by day, various solutions for

the generation of non-conventional energies have begun to arouse the interest of parties involved in maritime

transport. Non-conventional propulsion systems, which use wind energy or solar energy, are currently making

a comeback after being ignored for a long time. By using an unconventional power generator energy devices,

like Flettner Balloon, ship owners can save a great amount of fuel, thus making substantial savings and not

least, reducing pollution, making environmentally friendly ships. In this article you can discover six major

points, which are: 1) Flettner Balloon description, 2) Flettner Balloon components, 3) Determination of the

gas with which to fill the Flettner Balloon, 4) The principle of operation for the Flattner Balloon, 5)

Energy balance, 6) Conclusions.
POLYMODEL DESCRIPTION OF THE SHIP'S ELECTRIC POWER SYSTEM
Authors: Boychuk Igor , Grinek A , Kornev A. , Fischenko A. , Slepov O.
Published: March 2023

The article presents a complex of mathematical models of various classes and types and the results of their

application in the description of the ship's electrical power system. The technique for determining the frequency

characteristics of the propeller shaft system is shown. The ship electric power system is presented in the form

of three levels, which include main engines, generators, control systems, power converters, and an electric

propulsion system. It is shown how transient processes take place in the system when the load is turned on and

external moments change
CLOSED-LOOP MARINE ENGINE OPERATION WITH ZERO EMISSIONS OF HARMFUL COMBUSTION PRODUCTS
Authors: Vasilescu M.-V. , Volintiru O. , Epikhin Alexey Ivanovich , Toriya T.
Published: March 2023

In the modern world, the problem of environmental pollution with various toxic emissions is growing more and

more. Exhaust or exhaust gases of internal combustion engines are one of those man-made factors. All countries

impose restrictions on the concentration of hazardous substances, for example: Euro - for cars, Tier and Stage

- for heavy equipment and MARPOL-73/78, which regulates emissions from maritime transport. The situation

is extremely acute for marine vessels, since engines of impressive power that operate for a long period are

difficult to adapt to stringent environmental requirements. The purpose of the article, based on open sources, is

to evaluate the prospects for the development of internal combustion engines with an exhaust gas recirculation

system to minimize the amount of toxic emissions into the atmosphere. The development of technologies that allow for the recirculation of exhaust gases in ship conditions is quite promising. The installation of such equipment

will significantly reduce emissions into the environment.

Keywords: environment, exhaust gases, toxic emissions, internal combustion engines
Tissue Inhibitor Metalloproteinase-2 and Insulin-Like Growth Factor Binding Protein-7 Kinetics Following Exposure to High-Dose Methotrexate
Authors: Barreto Jason N. , Barreto Erin F. , Mara Kristin C. , Rule Andrew D. , Lieske John C. , Giesen Callen D. , Thompson Carrie A. , Leung Nelson , Witzig Thomas E. , Kashani Kianoush B.
Published: March 2023

Key Points

Urinary TIMP2×IGFBP7 (uTIMP2×IGFBP7) concentrations experienced a rapid and sustained decline after high-dose methotrexate (MTX) exposure.

uTIMP2×IGFBP7 kinetics and concentrations after high-dose MTX exposure demonstrated no utility in predicting AKI.
Druggable molecular targets of triple-negative breast cancer and prospects of therapeutic application
Authors: Nguyen Van Cau
Published: March 2023

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, which is characterized by deficient expression of estrogen receptor, progesterone receptor expression and the absence of human epidermal growth factor receptor 2 (HER2) expression/amplification. For the past few decades, due to the lack of druggable targets, conventional chemotherapy has been the mainstay of systemic treatment for TNBC. However, lack of molecular targeted therapies and poor prognosis of TNBC, much research has been devoted to identifying specific molecular targets that can be utilized for targeted cancer therapy to improve the clinical outcomes. Now, poly (ADP-ribose) polymerase (PARP) inhibitors, immune checkpoint inhibitors,
and antibody-drug conjugates have been approved by FDA for the treatment of TNBC. Moreover, agents that target signal transduction, angiogenesis, epigenetic modifications, and cell cycle are under active preclinical or clinical investigations. In this review, we summarize current significant achievements applied in treatment of TNBC with molecular targeted therapy, immunotherapy, and antibody-drug conjugates and upcoming drugs for triple negative breast cancer will be summarized.
Key words: triple-negative breast cancer (TNBC), breast cancer, estrogen
Hemoglobin concentration in ill neonates in early neonatal period
Authors: Nguyen Thi Thanh Binh , Pham Thi Ny , Nguyen Thi Thuy Lan , Hoang Thi Thanh Xuan , Ngo Thi Thuy Yen , Dinh Thi Hai Phuong , Pham Thi Thuy
Published: March 2023

Background: Abnormal changes in blood hemoglobin (Hb) levels depend on maternal and neonatal factors, and could be an important indicator to evaluate the progression of neonatal diseases. This study aims to describe the hemoglobin concentration in ill neonates and to identify several factors associated with anemia and polycythemia status in newborns in early neonatal period. Methods: A cross-sectional descriptive was conducted. A convenient sample included 169 ill neonates less than 7 day-old at Hue University of Medicine and Pharmacy Hospital from July 2021 to May 2022. Results: Mean gestational age in study group was 38.5 ± 2.2 weeks. The mean Hb concentration of study group was 180 ± 26.4 g/l. Prevalence of anemia and polycythemia were 18.9% and 6.5%, respectively. The mean Hb level in common diseases such as early-onset neonatal sepsis (EOS), meconium aspiration syndrome (MAS), ABO hemolytic disease of newborn (ABO HDN) was 181.7 ± 24.5 g/l, 164.5 ± 20.5g/l and 136.2 ± 18.5g/l, respectively. The incidence of anemia in EOS was 18.8%, in ABO HDN was 80.0%, in MAS was 33.3%. Factors significantly associated with neonatal anemia were ABO HDN (OR = 17.9, p < 0.05), maternal anemia (OR = 3.57, p < 0.05). Low birth weight neonates (< 2500 gram) increased the risk of polycythemia with OR = 3.94 (p < 0.05). Conclusion: The abnormal changes of hemoglobin concentration appears in 25.4% of ill neonates. The hemoglobin level should be screened to evaluate the disease characteristics of neonates.
Key words: ill neonates, neonatal anemia, polycythemia.
Evaluating the results of the surgery of benign parotid tumors
Authors: Vo Khac Trang , Hoang Minh Phuong , Nguyen Van Minh , Tran Tan Tai
Published: March 2023

Background: Benign tumors account for 80% of parotid salivary gland tumors, early diagnosis and effective treatment will contribute to reducing complications of surgery. Objective: To evalutate surgical results of benign parotid tumors on facial paralysis and other complications. Research Methodology: including 51 patients with benign parotid salivary gland tumors at Hue University of Medicine and Pharmacy Hospital from June 2019 to October 2021 were operated on and monitored for facial paralysis after 1 week, 1 month, 3 months, and 6 months according to the House-Brackmann facial nerve grading system and noted other complications. Results: Pleomorphic adenoma and Warthin tumors are the two most common types of benign tumors. The rate of facial paralysis at the time points after 1 week, 1 month, 3 months, and 6 months gradually decreased by 56.9%, 35.3%, 19.6%, 0%, respectively. Most temporary facial paralysis grade II (mild) and grade III (moderate) (classification of House - Brackmann). The surgical method was significantly related to facial paralysis (p < 0.05). Other complications such as numbness around the ear, hemorrhage, sialocele, salivary fistula, depression of facial contour, bad scars. Nevertheless, no cases of tumor recurrence and Frey’s syndrome were recorded after 6 months. Conclusion: Surgery is an effective and safe treatment for benign parotid salivary gland tumors. Facial paralysis accounts for a high incidence after surgery, but it will fully recover after 6 months. Choosing the appropriate treatment method helps to minimize complications and recurrence after surgery of parotid salivary gland tumors.
Key words: benign parotid tumors, facial paralysis, parotidectomy.
Методологія оцінки індикатора цілей сталого розвитку 11.3.1
Authors: Шелестов Андрій Юрійович , Куссуль Наталія Миколаївна , Яйлимов Богдан Ялкапович , Лавренюк Микола Сергійович , Яйлимова Ганна Олексіївна , Колотій Андрій Всеволодович , Шуміло Леонід Леонідович , Шуміло Леонід Леонідович , Пархомчук Олександр Михайлович
Published: March 2023

Проблема сталого розвитку міст привертає широку увагу в країнах всього світу, оскільки вона тісно пов’язана із якістю життя суспільства. Зростання площ міських територій часто є непропорційним відносно темпів зростання населення в країнах, що розвиваються, і тому цю розбіжність не можна контролювати за допомогою статистики. У цій статті здійснено дослідження на основі даних дистанційного зондування землі та статистичних даних. Запропоновані в даній статті методи дозволяють порівняти глобальний картографічний шар людських поселень (Global Human Settlement Layer — GHSL), що містить в собі інформацію про забудову, з власною картою земного покриву, а також розрахувати індикатор цілі сталого розвитку (ЦСР) 11.3.1 «Співвідношення рівня землекористування до рівня зростання населення» із використанням супутникових та геопросторових даних, які дають можливість розрахувати рівень землекористування, а також здійснити його валідацію, спираючись на глобальні продукти. Обчислення темпів зростання населення є більш простим і доступним, тоді як рівень споживання землі є дещо складним і вимагає використання нових методів. Оцінюючи рівень споживання землі, необхідно визначити, що таке «споживання землі», оскільки це може охоплювати аспекти «споживаної», «збереженої» або доступної для «освоєння» землі для таких випадків, як земля, зайнята водно-болотними угіддями. Крім того, немає жодного однозначного показника, чи є земля, яка забудовується, справді «новозабудованою» (або вільною), чи вона принаймні частково «перепланована». Як наслідок відсоток загальної міської землі, яка була нещодавно забудована (спожита), використовуватиметься як міра споживання землі. Повністю забудовану територію також іноді називають забудованою. У зв’язку з цим розроблено два підходи для обрахунку наведеного індикатора: один з них — для рівня країни, для чого використовуються глобальні продукти, а інший — для регіонального рівня, для чого використовуються місцеві карти класифікації, розроблені та створені за власною методологією. Результати даного дослідження демонструють, що дані GHSL мають високу точність для оцінки індикатора ЦСР на рівні країни або регіону, проте для розрахунку цього індикатора на рівні міста краще використовувати місцеві карти класифікації. Розроблена методологія класифікації земного покриву в хмарній платформі Google Earth Engine демонструє хороші результати з високим просторовим розрізненням 10 м і може використовуватися для аналізу забудованих територій різних міст за супутниковими даними.
The Impacts of Climate Change on Surfing Resources: Supplemental Online Materials
Authors: Sadrpour Nick , Reineman Dan
Published: March 2023

For the purposes of this review, we only discuss and consider impacts to wind-generated surface gravity waves on the ocean breaking in nearshore waters. The following non-technical summary of these processes is drawn from several sources, including (Garrison 2001, Hutt et al. 2001, Mead and Black 2001a, 2001b, Cool 2003, Scarfe et al. 2003, Butt et al. 2004, Espejo et al. 2014, Meldahl 2019). We divide the overview to focus separately on swell generation and wave breaking and also briefly summarize a variety of other factors relevant to breaking wave quality for surfing.
Bilecik Merkez Bölgesindeki Mermer Ocaklarının Arazi Değişimi ve Arazi Örtüsü Değişiminin Destek Vektör Makine Yöntemi İle Belirlenmesi
Authors: ALTUĞER Can , ULAMIŞ Koray
Published: March 2023

Bilecik ili Türkiye’nin en önemli doğaltaş alanlarından birisidir. Son yıllarda, Bilecik çevresinde yeni mermer ocaklarının açılmasıyla birlikte bölgede doğaltaş üretimi giderek artmıştır. Sakarya kıtasının batısında bulunan çalışma alanında birçok mermer ocağı bulunmaktadır. Bu kıtaya ait birimler, mavişist metamorfizması geçirmiştir. Metamorfik birimlerin üzerine uyumsuzlukla örten Geç Jura-Erken Kretase yaşlı birimler, transgresyona uğramıştır. Mermer ocaklarının yer aldığı Geç Jura-Erken Kreatese yaşlı birimler, Bilecik Formasyonu’ndan oluşmaktadır. Bu birimlerde; beyaz-pembe, kahverengi-gri ve bej renkli mermerler bulunmaktadır. Arazi kullanımı/arazi değişimi (LULC) sınıflaması kullanılarak uzaktan algılama yöntemi ile bölgedeki mermer ocaklarının 5 er yıllık (2006, 2011, 2016 ve 2021) arazi değişimi gösterilmiştir. Landsat 5 TM ve Landsat 8 OLI multispektral uydu görüntüleri makine öğrenme yöntemlerinden Destek Vektör Makineleri (DVM) metoduyla sınıflandırılmıştır. LULC doğruluğunu ispat etmek için doğruluk matrisi ve Kappa indisi oluşturulmuştur. Tematik haritaların doğruluğu sırasıyla %95,75 , %92,00, %93,60, %95,20, Kappa katsayısı değerleri de; 0,92, 0,86, 0,89, 0,91 olarak belirlenmiştir. Mermer ocak sayısının artması, katı atık miktarındaki artışı beraberinde getirmektedir. Bu durum, katı atık depolama sahalarının yetersiz kalması nedeniyle gelecekte kenti olumsuz olarak etkileyebilecektir.
The Socio-Economic Empowerment of Rural Women Workers
Authors: Senthilkumar R
Published: March 2023

Rural women enormously contribute to the family income through undertaking a number of agricultural activities and thereby achieving their socio-economic empowerment. Hence, the present study mainly aims at analyzing the socio-economic variables of rural women workers in terms age, marital status, educational qualification, experience, community, religion, family type, family size and family monthly income and contribution of women to family income for empowering in socially and economically.
Tendency to be Open to Learning Scale: Validity and Reliability Studies
Authors: Tunca Güçlü Nihal , Uyar Melis Yeşilpınar , Şahin Senar Alkın
Published: March 2023

This study aims to develop a valid and reliable measurement tool that will serve to determine the level of higher eduction students’ tendency to be open to learning. The sample of the research consists of 523 higher education students. As a result of the literature review and analysis, the dimensions predicted as sub-dimensions in the scale are “being curious/ investigative, reflecting, being open-minded, being planned, being patient. Within the scope of the validity studies of the Tendency to Be Open to Learning Scale (TOLS), exploratory factor analysis was performed and construct validity was determined. As a result of the exploratory factor analysis, a 5-point Likert-typetool with 22 items collected in four dimensions was reached. The resulting TOLS consists of “F1. being patient, F2. being open-minded, F3. being curious, F4. being planned” sub-dimensions. As a result of the exploratory factor analysis performed to determine the scale’s validity, it is seen that the four dimensions included in the scale explain 49.31% of the total variance.
Practice and Challenges of the Implementation of Inclusive Education Strategy in Secondary Schools: The Case of Gofa Zone, Southern Ethiopia
Authors: Fantaye Kocha Dawit , Senapathy Marisennayya
Published: March 2023

Inclusive Education (IE) is a practical approach to effectively accommodate students with disabilities (SWDs) in the general education classroom, whereby educational equity is believed to be realized. To that effect, the Federal Government of Ethiopia (FDRE) developed and rolled out its 2012 Inclusive Education Strategy (IES). This study assessed the implementation status of the strategy after a decade of enactment in secondary schools of the Gofa zone in South Nations, Nationalities and Peoples Regional State (SNNPRS). This study aimed to examine the practice and challenges of implementing the IES in secondary schools to contribute its share toa better realization of inclusivity. The survey, FGDs and KIIs have been employed to generate quantitative and qualitative data; results analysis has been made using an independent t-test and the mean score interpretation using Bluma (2012) intervals; and SPSS version 21 for frequency counts and percentages for comparing and contrasting perceptions and opinions. The study’s significant findings show that IES has not been effectively implemented in the Zone. Instead, challenged by different factors such as; lack of knowledge, understanding and awareness about the strategy; shortage of suitable inputs, physical facilities and teaching materials for the SWDs; leadership and management failure due to lack of understanding about the IES, and absence of reliable data about the CWD in the community. Filing the knowledge gaps of all the school community about the IES; conducting integrated leadership to make the schools suitable for SWDs; school-led- and community-assisted data collection on CWDs stand out asessential recommendations to improve the implementation.
Exploring Paraphrase Performances and Strategies of Graduate Student Writing
Authors: Çeşme Hatice
Published: March 2023

This study aims to investigate performances and strategies of EFL graduate students in terms of language proficiency, language background and type of writing task. The participants were 12 graduate students pursuing their doctoral studies in ELT at a Turkish university. A chosen text was used for data collection and the students’ paraphrased texts were analyzed employing Keck’s (2006) the taxonomy of paraphrase types and ‘a paraphrase found form’ developed by the researcher in terms of lexical and structural changes. The results of the study revealed that graduate students had challenges in appropriate implementation of paraphrasing in their task. While they generated frequently moderate level of paraphrases, the strategies they often used were synonym substitution as well as copying strings of words from source. Additionally, deviated meaning was designated as a new paraphrase type in the taxonomy of paraphrase. These findings suggest that students need an explicit paraphrasing instruction supported by good and bad paraphrase examples and more practice to learn how to paraphrase appropriately.
A Study of Service Quality and Customer Expectation Towards Online Purchasing of Variety Products
Authors: Rethesh Kumar A
Published: March 2023

The examination attempts to analyze consumer loyalty towards internet shopping. Web based shopping offers the best value, great items and totally simple shopping. The achievement of any e-tailor organization in India is dependent upon its ubiquity. Internet shopping has picked up significance in the cutting edge business climate. The advancement of web based shopping has opened the entryway of an opportunity to give an upper hand over firms. Internet shopping has filled in notoriety throughout the years mostly as individuals think that its reasonable for the solace of their home or work environment. In the past, the web keeps a valuable spot inside monetary exercises. Presently people show their advantage on the web.
Preventive Strategies of Child Sexual Abuse in School Settings: A Meta - Analysis
Authors: Arulselvi V , Geetha N
Published: March 2023

Most likely, child sexual abuse is a health issue that affects children and has the wide-ranging negative effects. The prevention of child sexual abuse in school settings is examined in this paper, along with a number of other factors that may affect the lives of victims. An electronic database search has been conducted to identify literature related to (child sexual) abuse preventive strategies given at schools in English. Investigators reviewed 62 studies out of which 13 studies illustrated the outcomes of the child sexual abuse preventive strategies followed in schools were successful. It was found that very few research had been conducted to prevent child sexual abuse in school settings, and additional intervention techniques were required globally.
Management der Borreliose in der Pädiatrie
Authors: Büttcher Michael , Kahlert Christian R. , Heininger Ulrich
Published: March 2023

Die Borreliose ist eine Multisystemkrankheit, ausgelöst durch Infektion mit dem Bakterium Borrelia burgdorferi sensu lato. Von der Infektion betroffene Organe sind vor allem Haut, Nervensystem, Gelenke, Herz und Augen.
Traitement antibiotique rationnel en pratique pédiatrique
Authors: Bielicki Julia Anna , Kohns Vasconcelos Malte
Published: March 2023

Les antibiotiques figurent parmi les médicaments les plus utilisés en pédiatrie. Dans un contexte de résistances bactériennes croissantes contre les antibiotiques au courant de la dernière décennie, l’utilisation scrupuleuse et rationnelle de ces médicaments est apparue comme étant essentielle afin de conserver leur efficacité globalement le plus longtemps possible.
Sur les lieux d’un cas infectiologique – enquête diagnostique: réflexions à propos des indications et limites des analyses microbiologiques courantes
Authors: Schöbi Nina , Duppenthaler Andrea
Published: March 2023

Les moyens diagnostiques en infectiologie ont connu ces dernières années une expansion grâce notamment aux moyens de détection de la génétique moléculaire. Les différentes analyses ont leur place dans le diagnostic d’une maladie infectieuse, si elles sont effectuées avec la bonne question au bon moment. Tout résultat positif n’est par contre pas nécessairement cliniquement significatif ou un indice diagnostique fiable. Les limites de l’analyse en question doivent être prises en considération lors de l’évaluation d’un résultat.
Deliberative Planning Analysis: Study on Policy-Making Inhibiting Factors in Musrenbangdes
Authors: Rafinzar Rahmat , Marpaung Zailani Surya , Khairunnas Khairunnas , Ismail Rizky Ghoffar
Published: March 2023

The success of the Musrenbangdes policy implementation will always be determined by various factors. Inhibiting factors are often the cause of the ineffective implementation of a policy. This research was conducted to look at the inhibiting factors in making Musrenbangdes policy which is seen in the scope of deliberative planning. This study uses a descriptive research method with a qualitative approach. The data analysis techniques used by the researchers are interactive models from Miles and Huberman. Research conducted in Pulau Rimau District, Banyuasin Regency, South Sumatra found that there were inhibiting factors in the implementation of Musrenbangdes that led to the decision-making process in deliberative planning. Some of these factors are the involvement of community interest groups that have not been fully involved or are still in the form of representatives. Determination of participant representatives in Musrenbangdes has not been seen based on age group which causes inclusiveness of public involvement to be not created. In addition, public involvement has not been seen based on socio-economic backgrounds such as education, employment, and the strategic location of activity locations. This has an impact on the deliberative planning process that has not been able to run effectively and inclusively. The involvement of interest groups, age groups, social and economic backgrounds of the community is important to consider in determining Musrenbangdes participants to create a deliberative planning process that accommodates all stakeholders.
Saudi Arabia's Efforts in Implementing Saudi Vision 2030
Authors: Syaputra Fardien Faiz , Prasodjo Haryo
Published: March 2023

Saudi Arabia is a country that is quite rich in oil production. But within a few years of peaking at the top, world oil prices have declined, which has seen Saudi Arabia drop below the United States. The government of Saudi Arabia then responded to the decline in the economy caused by fluctuating oil prices by compiling the Arab Vision 2030. The goal of the Arab Vision 2030 is to diversify the economy or want to release Saudi Arabia's economic dependence on oil production. This study seeks to analyze the efforts made by Saudi Arabia in implementing the Arab Vision 2030. This issue is more focused on the efforts that have been planned and will be carried out. This study uses the concept of national interest to analyze Saudi Arabia's efforts to implement Saudi Vision 2030. This research was conducted using a qualitative method with a literature study and case study approach. The data was collected through primary and secondary data in the form of articles, journals, and news in the mass media. This study concludes that several efforts made by Saudi Arabia began with new, more liberal policies and the creation of several infrastructures that support Saudi Arabia's economic diversification. Saudi Arabia is trying to increase its economy through the non-oil and gas sectors. Muhammad bin Salman, the Crown Prince, has a very important role in making policies related to economic diversification in Saudi Arabia. The efforts can still be seen from various aspects, such as increasing Saudi Arabia's investment in several countries and changing patterns of economic development in the non-oil and gas sector
Factors affecting military expenditures in the Asia-pacific: Evidence from a panel-data, Quantile regression, and FMOLS
Authors: Aden Kadir
Published: March 2023

The current study investigates factors affecting military expenditures within the Asian-Pacific context. By doing so, a period ranging from 2005 to 2021 was selected with ten diverse countries from the region. Several statistical analyses consisting of an OLS, fixed & Random effect was performed. Whereas a quantile regression was also included to capture the omitted effects of the panel data. Likewise, an FMLOS was used to better evaluate the long-run effect and the relationships among the factors. According the findings, financial development (FND), Trade (TR) and Technological innovation have positive effect on defense expenditures, the following effect was backed by the FMOLS estimates which demonstrated a similar finding making the results more robust. On the other hand, economic growth (GDP) and bureaucratic effectiveness (BR) displayed a negative sign in the rise of military expenditures. At the same time, FDI inflow manifested a positive significant effect, but, only in the OLS model and through the upper percentiles. Overall, the research is the first to encompass several macroeconomic factors with other external variables to assess Asia-pacific security expenditures. And indeed, with the current global conflicts, it is hoped this research will provide a decent information about the ineffectiveness and effectiveness threshold of increasing defense expenditures.
EFFECTIVENESS OF HUMAN RESOURCES INFORMATION SYSTEM (HRIS) ON ORGANISATIONAL PERFORMANCE IN THE BANKING SECTOR
Authors: J. Magege Theodosia , Ngirwa Dr. Charles Cleophace
Published: March 2023

Human Resources Information System (HRIS) has become an important feature of Human Resource Management (HRM) in the emerging economies including Tanzania. The system has been adopted by several organizations but evaluation of its contribution to organization performance is rarely undertaken. In this paper, we report on the usefulness associated with the Human Resources Information System (HRIS) in banking sector casing Azania Bank Limited. The study aimed at investigating the importance of Human Resource Information Systems to the performance of Azania Bank Limited. The study findings show that HRIS contributes to the organization performance, the study adopted descriptive research targeting 133 respondents serving all employees of ABL headquarters. The data were collected using structured questionnaires which were subjected to descriptive and inferential analysis in the statistical package for social sciences (SPSS). Correlation and regression analysis were also undertaken based on the pre-established regression models. Results indicated that HRIS has significantly improved both employees’ and the managements’ access to human resource data across the institution. It was also established that highly significant (p < 0.001) improvement of working standards was attained as the result of using HRIS. The study concluded that HRIS system is important in an organization due to significant positive correlations between organization performance and HRIS importance (R = 889). A few employees express difficulties in using the HRIS due to low computer literacy. The study recommends that ABL should invest more in exposing its employee to experience and familiarize them with the system and engage employee in the tailoring of organization system by analysis, design, construction and development of the system to improve their performance.
La reduplicacion compleja en euskera: notas acerca de su formación y sus paralelos en otras lenguas
Authors: Igartua Ugarte Iván
Published: March 2023

Las construcciones vascas basadas en la reduplicación con m- inicial representan un tipo de composición léxica muy extendido en diversas lenguas europeas y asiáticas. La procedencia última de este peculiar mecanismo de reduplicación compleja, o reduplicación total con variación, se localiza en el conjunto de lenguas túrquicas. A partir de estas, el recurso parece haberse difundido con relativa facilidad tanto hacia el oriente como hacia el occidente del foco originario. La forma y la función de los compuestos vascos coinciden en alto grado con las que caracterizan al mühleme turco, pese a lo cual ambos procedimientos de creaciónléxica no han sido vinculados entre sí hasta la fecha, salvo desde una perspectiva tipológica. La presencia de formas reduplicadas de carácter...
«Cer alcatte edo alcatte ondo» Un dato para la geografía histórica del euskera en la Llanada alavesa (Axpuru y Heredia)
Authors: González de Viñaspre Gonzalo Roberto , Uribarrena Urionaguena Pedro
Published: March 2023

Presentamos aquí el pleito que enfrentó a la villa de Salvatierra-Agurain y al lugar de Axpuru con la hermandad de Barrundia y el lugar de Heredia. El documento contiene información sobre la disputa acontecida en octubre de 1740 entre los vecinos de Axpuru y de Heredia por el aprovechamiento de leña del monte Armendia. De las declaraciones de testigos, sabemos que en el altercado algunos de los protagonistas utilizaron la lengua vasca; en concreto, que un vecino de Heredia replicó a otro de Axpuru con la expresión cer alcatte edo alcatte ondo. En este trabajo contextualizamos y relacionamos este dato con otros ya conocidos de la geografía histórica del euskera en la zona nororiental de Álava.
Euskararen laguntzaile ahantziaz: *iron aditzaren historia
Authors: Padilla Moyano Manuel
Published: March 2023

Orain arteko ikerketa saioek albo batera utzi dute euskal aditz laguntzaileen sistemaren kide bat: *iron aditza. Geografikoki gero eta ekialderago plegatua, eta funtzionalki aditz iragankorren modu markatuei mugatua, *iron laguntzailea *ezan aditzarekin lehian ageri da historikoki. Lan honetan, batetik, *iron aditzaren inguruan plazaratu den informazio guztia bildu dugu, eta bestetik, ikerketa morfologikoa eta sintaktikoa gauzatu, ehun testutik gora biltzen duen corpus batetik abiaturik. Ikuspegi diakronikotik, *iron-en bilakaera errezesiboa ez da balizko defektibotasun morfologiko batez azaldu behar, objektu pluralarekiko formak zein joskera hirupertsonala ongi lekukotuak baitira aldi historikoan. Gure ustez, aditz honen gibelatzea gehiago esplika liteke laguntzaileen sisteman izan duen posizio ahulagatik.
Euskararen belaunez belauneko jarraipena eta hizkuntza sozializazioa Nafarroako familia euskaldunetan (1970-2012)
Authors: Kasares Corrales Paula
Published: March 2023

Artikulu honetan Nafarroako historia hurbilean (hondar lau hamarkadetan, 1970etik 2012ra) euskararen belaunez belauneko jarraipena nola gauzatu den eta egungo haur nafarrak zer egoeratan bilakatzen diren euskaldun aztertu da. Horretarako, egilea hizkuntza sozializazioaren eredu teoriko-metodologikoaz baliatu da. Sozializazio kontzeptuak gizarte erreprodukzio eta transmisio adigaietan oinarritutako ikusmolde ohikoek oraindaino ikusezin utzitako hainbat alderdiri eta horien arteko elkarreraginei erreparatzea ahalbidetzen du. Iruritan (Baztanen) eta Iruñean egindako landa ikerketek erakutsi dutenez, Nafarroako euskararen belaunez belauneko jarraipenak hizkuntza-sozializazio prozesua izan du euskarri. Hizkuntza sozializazioak hiztunen bizialdi osoa, ez haurtzaroa soilik, hartzen du; prozesu orohartzailea da, familiara mugatzen ez dena; dinamikoa eta baldintza soziohistorikoei lotua, ez mekanikoa; elkarreragilea, ez noranzko bakarrekoa; malgua eta denboran aldakorra, ez beti-batekoa. Haurren euskarazko sozializazioa elkarri lotutako bi ardatzetan funtsatzen da: belaunaldien arteko elkarreraginetan (familian batik bat) eta adinkideen arteko harreman eszentrikoetan (familiatik kanpo batez ere).
LADYS STRONG IN POLITIC INDONESIA
Authors: Irnawaty Asci , Rudinan Rudinan , Muh. Karman La Ode , Darman La Ode
Published: March 2023

The purpose of this writing is to analyze and find out the position of strong women in politics in Indonesia. As a result of Indonesian politics experiencing significant and increasingly mature developments, the emergence of female names as a representation of Indonesian women. The research method uses literature studies from various reliable and accountable sources. The results of the study explain that the results of the analysis regarding Megawati's existence in Indonesian politics as well as becoming a female figure who is still involved in national politics and being the sole elite in the leadership of the Indonesian Democratic Party of Struggle (PDI-P). This cannot be separated from indoctrination through the understanding of inheritance from the father. Cognitive aspects that are selling points in political competition are both Curtain (traits), Belief (trust), Complexity of thoughts and patterns of reasoning. These aspects later shaped Megawati so that Megawati's quality could not be doubted. Megawati's lasting power and influence and no other figure can replace her.