bluuebunny/crossref_metadata_2025 huggingface dataset:
Penerapan Model Pembelajaran Interaktif Berbasis Konsep Untuk Meningkatkan Hasil Belajar Kognitif Fisika Siswa
Authors: Susilawati Susilawati , Nawansi Susi Putri , Sutrio Sutrio , Doyan Aris
Published: July 2023

The results of learning physics class X.C students at SMAN 1 Kediri are still low. One of the learning models that can increase the learning outcomes of students of class X.C physics is the Concept-Based Interactive Learning Model. This study aims to improve the results of learning physics class X.C students at SMAN 1 Kediri in the academic year 2015/2016 on Dynamic Electricity learning through the application of Concept-Based Interactive Learning Model. The type of research used is Classroom Action Research which is carried out in two cycles. Each cycle includes the stages of planning, implementing, observing and evaluating, and reflecting. The results showed that the mean value of students which is the result of learning in this study, the results in cycle I and cycle II are 72.95 and 79.10 respectively, with classical completeness sequences of 63.63 and 86.36%. Looking at the overall results of the study, it can be concluded that the application of the Concept-Based Interactive Learning Model can increase the learning outcomes of students of class X.C physics at SMAN 1 Kediri in the academic year 2015/2016 on the subject of Dynamic Electricity.
OS FATORES DETERMINANTES PARA A FALHA EM TERAPIAS POR IMPLANTES OSSEOINTEGRADOS
Authors: BRITO Igor Oliveira Aguiar , PENHA Vitória Lopes da , LOPES Vivian Maria Porto , LOPES Caio Rodrigo Pacheco
Published: July 2023

ntrodução: O desenvolvimento de implantes dentários osseointegrados para reabilitação bucal revolucionou as reabilitações orais protéticas, possibilitando tanto uma evolução na estética quanto na devolução da função mastigatória. Ainda que possuam uma grande taxa de sucesso, existem diversos fatores que influenciam no sucesso ou falha desses procedimentos. A assistência clínica e radiográfica em longo prazo de pacientes submetidos a implantes dentários é necessária, incluindo o retorno periódico para avaliação da higiene bucal e das condições de saúde, pois, assim, a possibilidade de falha pode ser reduzida. Objetivo: Realizar uma revisão de literatura desde os princípios básicos da ossintegração, até os procedimentos técnicos da implantodontia para um resultado de sucesso e falhas nos implantes osseointegrados. Método: Pesquisa bibliográfica realizada em bases de dadoscientíficos, Google Acadêmico, Scielo e BVS (Biblioteca Virtual em Saúde) com palavras- chaves: Falha precoce; implante dentário; osseointegração; próteses. Resultado: A osseointegração é considerada um dos maiores avanços na odontologia moderna. Refere-se ao processo de união do osso ao implante dentário seja fixado de forma estável e duradoura no osso. Os casos de sucesso têm sido cada vez maiores por conta da previsibilidade e tecnologia que a nova era da odontologia conta. Conclusão: Com o avanço continuo da tecnologia dentro da odontologia tornou-se um procedimento comum e altamente previsível. Extremamente vantajosa entre os pacientes, que buscam uma reabilitação oral.

Palavras-chave: Falha precoce. Implante dentário. Osseointegração. Próteses.
ANÁLISE DA BANALIZAÇÃO DA LIPOASPIRAÇÃO, OS PERIGOS DA CIRURGIA PLÁSTICA E A INFLUÊNCIA DA MÍDIA
Authors: RODRIGUES Gabriela Lopes Pereira , Lemes Neto Edílio Póvoa , VASCONCELOS Ana Carolina Sobota
Published: July 2023

Introdução: O meio da internet é parte do cotidiano da população, têm crescido em número com um enorme potencial para alcançar e disseminar informações, seja
pessoal, ou comercial. Deste modo, o uso das redes sociais tornou-se uma ferramenta de marketing para a cirurgia plástica, como a promoção de negócios. Embora benéficas, as mídias sociais podem causar dilemas éticos se usadas incorretamente. Levantando o questionamento quanto à banalização da Lipoaspiração, os perigos da cirurgia plástica e a influência da mídia para realização de procedimentos estéticos. Metodologia: A metodologia deste trabalho é uma revisão de literatura sistemática. Plataformas de pesquisa utilizadas Google Scholar, Scielo, UptoDate PubMed. 4.291 mil
artigos na área, nos últimos 10 anos. Resultados: os artigos analisados versam sobre: os impactos das mídias sociais, padrão estético irreal, práticas e técnicas do procedimento e pós-operatório que visam os benefícios e sucessos da cirurgia,
critérios de segurança necessários para realização da cirurgia, os riscos e as causas de óbito de pacientes submetidos ao procedimento. Discussão: Com o surgimento das mídias sociais e com o crescimento do número de influenciadores digitais tornou-se comum a busca pelo ideal de corpo padrão estético no cotidiano, afetando autoestima e causando distúrbios e transtornos de autoimagem em milhões de pessoas. E a forma de alcance propagada para o alcance deste corpo perfeito mais comum é por meio de procedimentos estéticos. Considerações Finais: A lipoaspiração é um procedimento cirúrgico sério, com riscos envolvidos, como: embolia gordurosa, tromboembolismos, infecção, perfuração, seroma e risco de morte.

Palavras-chave: Cirurgia Plástica. Influência do Grupo. Lipoaspiração.
A NÃO MATERNIDADE COMO POSSÍVEL FATOR DE ESTIGMATIZAÇÃO SOCIAL DA MULHER
Authors: SILVA Lorena Reinaldo da , PINHO Eduardo Fagner Machado de , SOUSA Jordana Carmo de
Published: July 2023

Na contemporaneidade, algumas mulheres têm se posicionado frente à escolha pela não maternidade, produzindo novas formas de subjetivação. Esse fenômeno possibilita o questionamento quanto à construção da identidade feminina subordinado à maternidade. Para tanto não se pretende esgotar as possibilidades de pesquisa com este trabalho. Por esse viés, este artigo busca compreender, se no contexto contemporâneo as mulheres não mães sofrem estigmatização, adentrando nos contextos sócio-histórico-cultural a construção do ser mãe; além de se propor a investigar as possíveis representações sobre a feminilidade e a relação com a maternidade. Diante disso, verificou-se a ocorrência da maternidade como resultante dos discursos sociais e científicos. E por fim a estigmatização posto ao desejo de não ocupar o papel de mãe. Realizou-se, então uma pesquisa de cunho bibliográfico, de abordagem qualitativa e descritiva.

Palavras-chave: Não maternidade. Estigmatização. Feminilidade.
MORTALIDADE POR TROMBOEMBOLISMO PULMONAR DURANTE A PANDEMIA DO COVID-19 NA REGIÃO NORTE EM RELAÇÃO ÀS DEMAIS REGIÕES DO BRASIL
Authors: LOPES Asthon Carvalho Ribeiro , LOPES Athilio Carvalho Ribeiro , CHIACCHIO Gabriel Machado , ARAÚJO Vitória Bandeira , BLOIS Ricardo Russi
Published: July 2023

o mundo, com um aumento significativo na mortalidade em diferentes regiões. O objetivo desta revisão sistemática foi avaliar a mortalidade por tromboembolismo pulmonar (TEP) durante a pandemia do COVID-19 na Região Norte do Brasil em relação às demais regiões do país. Foi realizada uma busca sistemática nas bases de dados PubMed, Scopus e Web of Science para artigos publicados entre janeiro de 2020 e dezembro de 2021. Os resultados indicam que houve um aumento significativo na mortalidade por TEP durante a pandemia do COVID-19 em todas as regiões do Brasil. A taxa de mortalidade por TEP foi de 6,7% na Região Norte, enquanto nas demais regiões variou de 3,9% a 5,2%. Isso pode ser explicado pela falta de acesso aos cuidados médicos especializados na região e pela alta incidência de comorbidades associadas ao TEP, como obesidade e doenças cardiovasculares. Conclui-se que é necessário fortalecer as políticas de saúde pública para melhorar o acesso aos cuidados médicos especializados e prevenir a mortalidade por TEP durante a pandemia do COVID-19.

Palavras-chave: Pandemia. COVID-19. Tromboembolismo Pulmonar. Mortalidade. Região Norte do Brasil.
Diseminasi Implementasi Kurikulum Merdeka Belajar pada Guru-Guru SMK Madani Makassar
Authors: Musdalifah  , Prasetyo Muh. Mulyadi , Sumarni AR  , Yunus Muhammad
Published: July 2023

One of the important tools that must be owned and mastered by teachers in the successful implementation of the Independent Curriculum is an understanding of the important elements in the Independent Learning Curriculum. The Merdeka Curriculum dissemination activity is part of the training activities for the implementation of the Independent Curriculum and the Learning Process in the Classroom, which is the result of a collaboration between Patompo University and SMK Madani Makassar. The implementation of the activity was carried out in the Makassar Madani Vocational School Hall on November 24 2022. The dissemination was carried out face to face with the target of class teachers at Madani Makassar Vocational School. The purpose of the dissemination is so that teachers are ready to use the Independent Curriculum with independent learning options. The implementation of the dissemination includes exposure to the components of the Independent Learning Curriculum, learning style quiz tests and reflection on the results of the learning style quiz tests so that the readiness of the Madani Vocational School Teachers in Makassar can be known.
Learning argumentation frameworks from labelings
Authors: Bengel Lars , Thimm Matthias , Rienstra Tjitze
Published: July 2023

We consider the problem of learning argumentation frameworks from a given set of labelings such that every input is a σ-labeling of these argumentation frameworks. Our new algorithm takes labelings and computes attack constraints for each argument that represent the restrictions on argumentation frameworks that are consistent with the input labelings. Having constraints on the level of arguments allows for a very effective parallelization of all computations. An important element of this approach is maintaining a representation of all argumentation frameworks that satisfy the input labelings instead of simply finding any suitable argumentation framework. This is especially important, for example, if we receive additional labelings at a later time and want to refine our result without having to start all over again. The developed algorithm is compared to previous works and an evaluation of its performance has been conducted.
Adaptive action-prediction cortical learning algorithm under uncertain environments
Authors: Fujino Kazushi , Aoki Takeru , Takadama Keiki , Sato Hiroyuki
Published: July 2023

The cortical learning algorithm (CLA) is a time series prediction algorithm. Memory elements called columns and cells discretely represent data with their state combinations, whereas linking elements called synapses change their state combinations. For tasks requiring to take actions, the action-prediction CLA (ACLA) has an advantage to complement missing state values with their predictions. However, an increase in the number of missing state values (i) generates excess synapses negatively affect the action predictions and (ii) decreases the stability of data representation and makes the output of action values difficult. This paper proposes an adaptive ACLA using (i) adaptive synapse adjustment and (ii) adaptive action-separated decoding in an uncertain environment, missing multiple input state values probabilistically. (i) The proposed adaptive synapse adjustment suppresses unnecessary synapses. (ii) The proposed adaptive action-separated decoding adaptively outputs an action prediction separately for each action value. Experimental results using uncertain two- and three-dimensional mountain car tasks show that the proposed adaptive ACLA achieves a more robust action prediction performance than the conventional ACLA, DDPG, and the three LSTM-assisted reinforcement learning algorithms of DDPG, TD3, and SAC, even though the number of missing state values and their frequencies increase. These results implicate that the proposed adaptive ACLA is a way to making decisions for the future, even in cases where information surrounding the situation partially lacked.
Huntington’s Disease Clinical Trials Corner: August 2023
Authors: Estevez-Fraga Carlos , Tabrizi Sarah J. , Wild Edward J.
Published: July 2023

In this edition of the Huntington’s Disease Clinical Trials Corner, we expand on the GENERATION HD2 (tominersen) and on the Asklepios Biopharmaceutical/BrainVectis trial with AB-1001. We also comment on the recent findings from the PROOF-HD trial, and list all currently registered and ongoing clinical trials in Huntington’s disease.
Indications for Tube Feeding in Adults with Muscular Disorders: A Scoping Review
Authors: Middelink Marloes , Voermans Nicol C. , van Engelen Baziel G.M. , Janssen Mirian C.H. , Groothuis Jan T. , Knuijt Simone , Zweers-van Essen Heidi
Published: July 2023

Background: Eating an adequate diet and maintaining a healthy body weight can be challenging for patients with muscular disorders (MD). Starting tube feeding can have a positive impact on nutritional status, functioning and quality of life. Guidelines on when to start tube feeding in adults with MD are lacking. Objective: We aim to review the scientific literature on indications to start tube feeding in adults with facioscapulohumeral dystrophy (FSHD), inclusion body myositis (IBM), muscular dystrophy type 1 (DM1), oculopharyngeal muscular dystrophy (OPMD) and congenital myopathies. Methods: This scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR) guidelines. Relevant studies were identified in Pubmed, Embase and Cinahl (April 2022). The medical subject headings (MeSH) and text words used were related to FSHD, IBM, DM1, OPMD or congenital myopathies and dysphagia, enteral nutrition or malnutrition. Results: Of 1046 unique articles, 9 case reports and 2 retrospective case series were included. Indications to start tube feeding were dysphagia, malnutrition/weight loss and respiratory infections (due to aspiration). Percutaneous endoscopic gastrostomy (PEG) tubes were used most often and complications were respiratory failure, problems with the tube itself, accidental tube removal, cutaneous symptoms, digestive symptoms, and peritonitis. Conclusion: Data on tube feeding in MD is scarce. Indications to start tube feeding were similar across the various MD. We call for more research in this field and suggest to include screening for dysphagia, aspiration and malnutrition in for the treatment of various MD.
Evaluation of visual plasticity in patients with refractive amblyopia treated using a visual perceptual learning system
Authors: Lan Fang-Fang , Zhao Wu-Xiao , Gan Lu
Published: July 2023

BACKGROUND: Amblyopia is a neurological deficit in binocular vision that affects 3% of the population and is the result of disruptions in early visual development. OBJECTIVE: In this study, we used a visual perceptual learning system for the short-term treatment of children with ametropic amblyopia and evaluated the clinical efficacy of this system in terms of visual plasticity. METHODS: We conducted a retrospective analysis of the clinical data of 114 children (228 eyes) with refractive amblyopia, who were aged 6.51 ± 1.51 years. Prior to the treatment, we evaluated all children with amblyopia using the visual information processing test. We determined the type of amblyopic defect according to the type of amblyopia, corrected visual acuity, and advanced visual function test results. Based on the type of defect, each child with amblyopia was given short-term visual perception training for 10 days. Finally, we compared the results of visual acuity and visual information processing tests before and after the treatment. RESULTS: The best-corrected visual acuity of patients was better after 10 days of visual training than that before training (P< 0.05). The perceptual eye position after training improved with statistically significant differences in horizontal and vertical perceptual eye position (both P< 0.05) compared to that before training. The number of amblyopic children without suppression in both eyes was 81 cases (71.1%) after training which was higher than that (65 cases, or 57.0%) before training, with a statistically significant difference (P< 0.05). Binocular fine stereopsis and dynamic stereopsis improved after training with a statistically significant difference (both P< 0.05). CONCLUSION: In this study, it was found that patients with amblyopia showed visual plasticity. Moreover, continuous visual perceptual learning improved the best-corrected visual acuity and recovered stereopsis in children with refractive amblyopia.
Evaluation of machine learning algorithms for noninvasive intracranial pressure estimation using near infrared spectroscopy as a covariate
Authors: Narula Gagan , Boss Jens , Seric Marko , Baumann Daniel , Salles Joan P. , Fröhlich Jürg , Baumann Dirk , Keller Emanuela , Willms Jan
Published: July 2023

BACKGROUND: Intracranial pressure (ICP) is a vital parameter that is continuously monitored in patients with severe brain injury and imminent intracranial hypertension. OBJECTIVE: To estimate intracranial pressure without intracranial probes based on transcutaneous near infrared spectroscopy (NIRS). METHODS: We developed machine learning based approaches for noninvasive intracranial pressure (ICP) estimation using signals from transcutaneous near infrared spectroscopy (NIRS) as well as other cardiovascular and artificial ventilation parameters. RESULTS: In a patient cohort of 25 patients, with 22 used for model development and 3 for model testing, the best performing models were Fourier transform based Transformer ICP waveform estimation which produced a mean absolute error of 4.68 mm Hg (SD = 5.4) in estimation. CONCLUSION: We did not find a significant improvement in ICP estimation accuracy by including signals measured by transcutaneous NIRS. We expect that with higher quality and greater volume of data, noninvasive estimation of ICP will improve.
Detector-trigger-based cardiac multiphase micro-CT imaging for small animals
Authors: Shi Yu , Li Juntao , Li Ke , Zhang Xuexue , Chang Peng , Huang Zujian , Liu Yanyun , Wang Yihan , Zhan Yonghua , Cao Xu , Zhu Shouping
Published: July 2023

BACKGROUND: Micro-computed tomography is important in cardiac imaging for preclinical small animal models, but motion artifacts may appear due to the rapid heart rates. To avoid influence of motion artifacts, the prospective ECG gating schemes based on an X-ray source trigger have been investigated. However, due to the lack of pulsed X-ray exposure modes, high-resolution micro-focus X-ray sources do not support source triggering in most cases. OBJECTIVE: To develop a fast-cardiac multiphase acquisition strategy using prospective ECG gating for micro-focus X-ray tubes with a continuous emission mode. METHODS: The proposed detector-trigger-based prospective ECG gating acquisition scheme (DTB-PG) triggers the X-ray detector at the R peak of ECG, and then collects multiple phase projections of the heart in one ECG cycle by sequence acquisition. Cardiac multiphase images are reconstructed after performing the same acquisition in all views. The feasibility of this strategy was verified in multiphase imaging experiments of a phantom with 150 ms motion period and a mouse heart on a micro-focus micro-CT system with continuous emission mode. RESULTS: Using a high frame-rate CMOS detector, DTB-PG discriminates the positions of the motion phantom well in 10 different phases and enables to distinguish the changes in the cardiac volume of the mouse in different phases. The acquisition rate of DTB-PG is much faster than other prospective gating schemes as demonstrated by theoretical analysis. CONCLUSIONS: DTB-PG combines the advantages of prospective ECG gating strategies and X-ray detector-trigger mode to suppress motion artifacts, achieve ultra-fast acquisition rates, and relax hardware limitations.
Study on the Instrument for Testing Radiofrequency Ablation Catheter
Authors: Zhang Lei , Lu Wenbo , Sun Jianjun , Ai Chongchong , Lin Zechen , Han Naishui , Li Longfei , Jia Yufei
Published: July 2023

Objective — To design a detection instrument for detecting the quality of radiofrequency ablation electrode, which can quickly detect the physical properties of radiofrequency ablation electrode. Methods — The DC constant current source is introduced to measure the small resistance, test whether the thermocouple is well connected, and measure the resistance between the positive and negative wires of the thermocouple at the plug (1-core and 2-core) to determine whether the thermocouple is well connected. The resistance of the good product is about 40Ω. Detect whether the inner tube and outer tube of RF ablation are in good physical contact through resistance, and judge whether there is physical contact between the inner tube and outer tube by detecting the resistance between the positive conductor of thermocouple (2 cores) and RF connecting wire (3 cores). When in good contact, the resistance is about 0.5 Ω; Measure the short circuit between 4~8 cores of the plug and judge whether the code is correct. The measurement method of pipeline absolute tightness is adopted to detect the change of pipeline pressure. Results — The developed radiofrequency ablation electrode detector can accurately measure the resistance, circuit and pipeline tightness of radiofrequency ablation, and can meet the requirements of detection accuracy. Conclusion — The quality of the prototype is stable and can meet the needs of users.
Sultani Çekirdeksiz Üzüm Çeşidinde Farklı Dönemlerde Toplanan Salamura Amaçlı Yaprakların Bazı Fiziksel ve Kimyasal Özelliklerinin Belirlenmesi
Authors: ÇOBAN Harun
Published: July 2023

Türkiye’de bağlardan hem üzüm hem de asma yaprakları yoğun olarak üretilmekte ve tüketilmektedir. Asma yapraklarının hem taze hem de salamura şeklinde iç tüketimi ve ihracatı son yıllarda artmaktadır. Bölgemizde yaygın olarak yetiştirilen sultani çekirdeksiz üzüm çeşidinin yaprakları bu amaçla değerlendirilmektedir.

Araştırmada, Manisa'da iki farklı dönemde toplanan Sultana çekirdeksiz üzüm çeşidine ait yaprakların fiziksel özellikleri ile kalite özellikleri ve mineral element içeriklerinin belirlenmesi amaçlanmıştır.

Fiziksel özellikler açısından; yaprak en uzunlukları 12.3-14.7 cm, boy uzunlukları 9.4-10.2 cm, yaprak büyüklükleri 128.9-179 cm² arasında değişmektedir. Mayıs (My) ve Uç yaprakların (Uy) fiziksel özellikleri karşılaştırıldığında yaprak sayısı bakımından ortalama olarak 1 kg’daki yaprak sayısı %23.1 oranında azalmıştır. Buna karşın yaprak alanı, yaprak ağırlığı, yaprak boyu ve yaprak eni sırasıyla %3.7; % 8.1; % 8.6 ve %7.6 oranında artış olduğu tespit edilmiştir.

Kalite analizlerinde Mayıs ve uç yapraklarda kuru madde (My:%21,7-23.1, Uy:%23.8-28.4), kül miktarı (My:%1.23-1.55, Uy:%1.14-1.7), protein miktarı (My:3.86-4.10 g 100 g⁻¹, Uy:3.03-3.45 g 100 g⁻¹), indirgen madde (My:0.17-0.27 g 100 g⁻¹, Uy:0.43-0.75 g 100 g⁻¹), toplam asitlik (My:% 0.62-0.86, Uy:%0.27-0.43) ve ham selüloz (My:0.34-0.48 g 10 g⁻¹, Uy:0.70-0.98 g 10 g⁻¹) miktarları belirlenmiştir.

Mineral madde içerikleri açısından mayıs yapraklarına göre, uç yapraklarında Ca, Mg ve Cu içerik değerleri sırasıyla, %25.2; %47.2 ve %45.6 oranında yüksek bulunmuştur.
Studi Kompressibilitas Tanah Vulkanik yang Dipadatkan Dengan Cara Statik dan Dinamik
Authors: Prabowo Gagas , Rahardjo Paulus Pramono , Karlinasari Rinda
Published: July 2023

Pembangunan konstruksi jalan di Indonesia seringkali berada pada tanah vulkanik, dimana pilihan borrow pit akan menjadi terbatas pada tanah vulkanik. Pada konstruksi jalan tanah yang dipadatkan umumnya memiliki penurunan yang seketika, namun faktanya terjadi penurunan jangka panjang pada tanah yang telah dipadatkan. Umumnya kompaksi yang dilakukan di lapangan berbeda dengan di laboratorium. Dimana kompaksi dilapangan mengarah pada kondisi statis sedangkan di laboratorium secara dinamik. Penelitian ini bertujuan untuk menganalisis mekanisme pemadatan statik ataupun dinamik serta hubungannya dengan kompressibilitasnya. Penentuan creep menggunakan pengujian Oedometer dengan metode penjenuhan dan tidak dijenuhkan. Hasil uji di laboratorium menunjukkan bahwa perbedaan metode kompaksi akan mempengaruhi nilai berat isi kering tanah, dimana pada pengujian nilai berat isi kering pada kompaksi dinamik adalah sebesar 1,38 g/cm3 dan pada kompaksi statik adalah 1,44 g/cm3 atau naik sebesar 4,35% hingga 7,96%. Nilai koefisien konsolidasi sekunder meningkat seiring penambahan beban pada uji Oedometer, namun dengan karakteristik yang berbeda tiap sampelnya. Dalam penelitian ini nilai koefisien konsolidasi sekunder cenderung menurun 10% – 40% ketika menggunakan energi pemadatan yang lebih besar. Sedangkan nilai index kompressibilitasnya menurun hingga 52%.
Analisis Faktor Risiko Cost of Quality Terhadap Failure Cost Pada Pelaksanaan Pekerjaan Struktur Gedung Bertingkat
Authors: Everlyn Viorenza , Nugroho Arief Setiawan Budi , Triwiyono Andreas
Published: July 2023

Keberhasilan sektor konstruksi tidak luput dari biaya dan kualitas, dilaporkan bahwa kegagalan kualitas teridentifikasi mencapai 5 - 20% dari nilai kontrak proyek. Untuk mengurangi kegagalan kualitas dan biaya kegagalan pada pelaksanaan proyek kontruksi perlu adanya identifikasi cost of quality (COQ). Dalam penelitian konstruksi beton bertulang dipilih sebagai objek identifikasi COQ karena termasuk bagian dari struktur yang kritis. Tujuan penelitian mengkategorikan COQ dari faktor internal dan eksternal dan menganalisis potensi biaya yang dikeluarkan untuk faktor kegagalan tersebut. Analisa quality failure cost dilakukan berdasarkan pembobotan hasil matriks perbandingan berpasangan untuk didapatkan nilai Consistency Index (CI) dan Consistency Ratio (CR), serta menggunakan uji Kruskal Wallis sebagai pendekatan uji non-paramatrik. Hasil penelitian menunjukkan bahwa COQ sangat berpengaruh pada profitabilitas, dimana kegagalan kualitas internal tertinggi adalah pada faktor metode kerja yang memengaruhi kegagalan hasil akhir beton berupa kecacatan secara struktur maupun visual, sedangkan kegagalan kualitas eksternal tertinggi adalah pada faktor penggantian produk atas permintaan klien yang di sebabkan produk konstruksi yang dihasilkan tidak sesuai dengan spesifikasi ataupun tidak sesuai dengan fungsi yang diharapkan.  Berdasarkan faktor penyebab kegagalan kualitas tersebut, proses kontrol terhadap pelaksanaan saat memengaruhi hasil akhir dari kualitas produk hingga menyebabkan adanya permintaan, penggantian, dan perbaikan dari klien pada masa garansi. Biaya kegagalan yang memperngaruhi nilai kontrak tertinggi adalah sebesar 7,26% dari kegagalan internal dan 6,40% dari kegagalan eksternal.
Epidemiological data on health care-related infections (HAIs) reported in Brazil
Authors: Da Silva Maciel Natiele , Hech Dominski Bruno , Ruiz Mazzon Ricardo , Ferreira Fabienne Antunes
Published: July 2023

As Infecções Relacionadas à Assistência à Saúde (IRAS) constituem um grande problema à saúde pública mundial, já que estão relacionadas ao aumento de morbidade e mortalidade, aumentando custos hospitalares. Além disso, grande parte destas infecções estão relacionadas à microrganismos que apresentam resistência aos antimicrobianos (RM), dificultando o tratamento. Conhecer o perfil epidemiológico destas infecções contribui para o desenvolvimento de estratégias para o controle de IRAS/RM. Neste sentido, o presente trabalho realizou uma revisão bibliográfica de dados epidemiológicos das IRAS no Brasil publicados entre 2017-2022. Foram selecionadas 27 publicações científicas. 13 destas apresentaram prevalência/incidência geral de IRAS, com apenas um estudo multicêntrico, multisetorial e multietário. Os demais estudos reportaram taxas de IRAS a partir de dados epidemiológicos oriundos de infecções de corrente sanguínea, infecções de sítio cirúrgico e infecção urinária, entre outras. Quando disponíveis, os perfis microbiológicos/resistência a antimicrobianos foram incluídos, sendo compatíveis com o que reporta a literatura científica. A partir dos dados desta revisão, observou-se que, apesar dos avanços na área, os estudos que reportam taxas de IRAS ainda são escassos e limitados a um contexto específico no Brasil, evidenciando a necessidade de mais estudos multicêntricos e contínuos. Conhecer melhor a epidemiologia de IRAS a nível nacional e público possibilita um melhor planejamento, desenvolvimento de estudos científicos e implementação de estratégias de controle e mitigação destas infecções.
Chirality-biased protein expression profile during early stages of bone regeneration
Authors: Zeng Qiang , Zheng Huimin , Heng Boon Chin , Yao Weitong , Yang Yue , Jiang Shengjie , Deng Xuliang
Published: July 2023

Introduction: Chirality is a crucial mechanical cue within the extracellular matrix during tissue repair and regeneration. Despite its key roles in cell behavior and regeneration efficacy, our understanding of chirality-biased protein profile in vivo remains unclear.

Methods: In this study, we characterized the proteomic profile of proteins extracted from bone defect areas implanted with left-handed and right-handed scaffold matrices during the early healing stage. We identified differentially-expressed proteins between the two groups and detected heterogenic characteristic signatures on day 3 and day 7 time points.

Results: Proteomic analysis showed that left-handed chirality could upregulate cell adhesion-related and GTPase-related proteins on day 3 and day 7. Besides, interaction analysis and in vitro verification results indicated that the left-handed chiral scaffold material activated Rho GTPase and Akt1, ultimately leading to M2 polarization of macrophages.

Discussion: In summary, our study thus improved understanding of the regenerative processes facilitated by chiral materials by characterizing the protein atlas in the context of bone defect repair and exploring the underlying molecular mechanisms of chirality-mediated polarization differences in macrophages.
Development and validation of a copper-related gene prognostic signature in hepatocellular carcinoma
Authors: Shi Haoting , Huang Jingxuan , Wang Xue , Li Runchuan , Shen Yiqing , Jiang Bowen , Ran Jinjun , Cai Rong , Guo Fang , Wang Yufei , Ren Gang
Published: July 2023

Introduction: Reliable biomarkers are in need to predict the prognosis of hepatocellular carcinoma (HCC). Whilst recent evidence has established the critical role of copper homeostasis in tumor growth and progression, no previous studies have dealt with the copper-related genes (CRGs) signature with prognostic potential in HCC.

Methods: To develop and validate a CRGs prognostic signature for HCC, we retrospectively included 353 and 142 patients as the development and validation cohort, respectively. Copper-related Prognostic Signature (Copper-PSHC) was developed using differentially expressed CRGs with prognostic value. The hazard ratio (HR) and the area under the time-dependent receiver operating characteristic curve (AUC) during 3-year follow-up were utilized to evaluate the performance. Additionally, the Copper-PSHC was combined with age, sex, and cancer stage to construct a Copper-clinical-related Prognostic Signature (Copper-CPSHC), by multivariate Cox regression. We further explored the underlying mechanism of Copper-PSHC by analyzing the somatic mutation, functional enrichment, and tumor microenvironment. Potential drugs for the high-risk group were screened.

Results: The Copper-PSHC was constructed with nine CRGs. Patients in the high-risk group demonstrated a significantly reduced overall survival (OS) (adjusted HR, 2.65 [95% CI, 1.83–3.84] and 3.30, [95% CI, 1.27–8.60] in the development and validation cohort, respectively). The Copper-PSHC achieved a 3-year AUC of 0.74 [95% CI, 0.67–0.82] and 0.71 [95% CI, 0.56–0.86] for OS in the development and validation cohort, respectively. Copper-CPSHC yield a 3-year AUC of 0.73 [95% CI, 0.66–0.80] and 0.72 [95% CI, 0.56–0.87] for OS in the development and validation cohort, respectively. Higher tumor mutation burden, downregulated metabolic processes, hypoxia status and infiltrated stroma cells were found for the high-risk group. Six small molecular drugs were screened for the treatment of the high-risk group.

Conclusion: Copper-PSHC services as a promising tool to identify HCC with poor prognosis and to improve disease outcomes by providing potential clinical decision support in treatment.
Predictive value of the Framingham steatosis index for cardiovascular risk: a nationwide population-based cohort study
Authors: Cho Yun Kyung , Kim Myungjin , Kim Ye-Jee , Jung Chang Hee , Lee Woo Je , Park Joong-Yeol
Published: July 2023

Background

Non-alcoholic fatty liver disease (NAFLD) is common and is associated with cardiovascular (CV) disease and mortality. The Framingham steatosis index (FSI) was recently proposed as a diagnostic marker of NAFLD and was calculated from age, body mass index, triglyceride, aspartate aminotransferase, alanine aminotransferase, diabetes history, and hypertension status. We aimed to evaluate the predictive ability of FSI for CV risk using a large-scale population dataset from the Korean National Health Insurance Service–National Health Screening Cohort (NHIS–HEALS).

Methods

Among 514,866 individuals in the NHIS–HEALS, we excluded those who died, had a history of admission due to a CV event, and were heavy drinkers. The final study cohort comprised 283,427 participants. We employed both unadjusted and covariate-adjusted models in Cox proportional hazards regression analyses to determine the association between FSI and major adverse cardiovascular events (MACEs), CV events, and CV mortality.

Results

During a median follow-up of 5.9 years, we documented 9,674, 8,798, and 1,602 cases of MACEs, CV events, and CV mortality, respectively. The incidence of MACEs was 1.28%, 2.99%, 3.94%, and 4.82% in the first to fourth quartiles of FSI, respectively. The adjusted hazard ratios (95% confidence interval) for MACEs gradually and significantly increased with the FSI quartiles [1.302 (1.215–1.395) in Q2, 1.487 (1.390–1.590) in Q3, and 1.792 (1.680–1.911) in Q4], following an adjustment for conventional CV risk factors, including age, sex, smoking, drinking, physical activities, low-density lipoprotein cholesterol, estimated glomerular filtration rate, and waist circumference. Participants in the higher quartiles of FSI exhibited a noteworthy increase in the occurrence of CV event. However, upon adjusting for relevant risk factors, the association between FSI and CV mortality did not reach statistical significance.

Conclusion

Our study suggests that the FSI, which is a surrogate marker of NAFLD, has a prognostic value for detecting individuals at higher risk of CV events.
A comparison of the binding sites of antibodies and single-domain antibodies
Authors: Gordon Gemma L. , Capel Henriette L. , Guloglu Bora , Richardson Eve , Stafford Ryan L. , Deane Charlotte M.
Published: July 2023

Antibodies are the largest class of biotherapeutics. However, in recent years, single-domain antibodies have gained traction due to their smaller size and comparable binding affinity. Antibodies (Abs) and single-domain antibodies (sdAbs) differ in the structures of their binding sites: most significantly, single-domain antibodies lack a light chain and so have just three CDR loops. Given this inherent structural difference, it is important to understand whether Abs and sdAbs are distinguishable in how they engage a binding partner and thus, whether they are suited to different types of epitopes. In this study, we use non-redundant sequence and structural datasets to compare the paratopes, epitopes and antigen interactions of Abs and sdAbs. We demonstrate that even though sdAbs have smaller paratopes, they target epitopes of equal size to those targeted by Abs. To achieve this, the paratopes of sdAbs contribute more interactions per residue than the paratopes of Abs. Additionally, we find that conserved framework residues are of increased importance in the paratopes of sdAbs, suggesting that they include non-specific interactions to achieve comparable affinity. Furthermore, the epitopes of sdAbs are only marginally less accessible than those of Abs: we posit that this may be explained by differences in the orientation and compaction of sdAb and Ab CDR-H3 loops. Overall, our results have important implications for the engineering and humanization of sdAbs, as well as the selection of the best modality for targeting a particular epitope.
Comparison of joint status using ultrasound assessments and Haemophilia Joint Health Score 2.1 in children with haemophilia
Authors: Li Yanju , Wang Feiqing , Pan Chengyun , Zhang Jing , Zhang Qian , Ban Lingying , Song Lingling , Wang Jishi , He Zhixu , Zeng Xiaojing , Tang Dongxin , Liu Yang
Published: July 2023

Introduction

Ultrasound (US) has gained popularity in the evaluation of haemophilic joint diseases because it enables the imaging of soft-tissue lesions in the joints and bone-cartilage lesions. We aimed to determine the correlation between US evaluations and clinical assessments performed using HJHS 2.1 and to evaluate their respective characteristics in assessing early haemophilic arthropathy.

Methods

A total of 178 joints (32 knees, 85 elbows, and 61 ankles) in 45 haemophilia A patients (median age, 10 years; range, 6–15) were assessed using US and HJHS 2.1. Ultrasonographic scoring was performed in consensus assessments by one imager by using the US scores.

Results

The total HJHS 2.1 and US scores showed a strong correlation (rS=0.651, P=0.000, CI: 0.553–0.763), with an excellent correlation for the elbows (rS=0.867, P=0.000, CI: 0.709–0.941) and a substantial correlation for the knees (rS=0.681, P=0.000, CI: 0.527–0.797). The correlation for the ankles was relatively moderate (rS=0.518, P=0.000, CI: 0.308–0.705). Nine subjects (15.5%) without abnormalities, as indicated by HJHS 2.1, showed haemophilic arthropathy in US scoring. All nine joints showed moderate (1/9) to severe (8/9) synovial thickening in the ankle (5/9) and elbow joints (4/9). In contrast, 50 joints (50.5%) showed normal US scores and abnormal changes as indicated by HJHS 2.1. S scores correlated well with HJHS 2.1 for overall and individual joints.

Discussion

US could identify some early pathological changes in joints showing normal clinical findings, but still cannot replace the HJHS; however, it can serve as an imaging examination complementing HJHS 2.
Field testing and psychometric properties of Thai version of the Boston carpal tunnel questionnaire
Authors: Atthakomol Pichitchai , Nudchapong Jirawat , Sangseekaew Kamonwan , Manosroi Worapaka , Tongprasert Siam , Wongpakaran Tinakon , Wongpakaran Nahathai
Published: July 2023

Introduction

The Boston Carpal Tunnel Questionnaire (BCTQ) is a widely recommended patient-reported outcome measure to evaluate symptoms and functions in carpal tunnel syndrome (CTS) patients. We aimed to evaluate the translation and cross-cultural adaptation of the Thai version of the BCTQ (Thai BCTQ) and to investigate the psychometric properties including internal consistency, test-retest reliability, construct validity and responsiveness.

Methods

The Thai BCTQ was field tested with 15 healthy volunteers and 15 CTS patients to evaluate the item-objective congruence of each item. Following that, one hundred and twenty-four CTS patients were included for psychometric evaluation in this study. Internal consistency was assessed using Cronbach’s alpha. Test-retest reliability was examined using the intraclass correlation coefficient (ICC). To evaluate construct validity, Spearman’s rank correlation of the symptom severity scale (Thai BCTQ -S), the functional status scale (Thai BCTQ -F) and the subscales of the Thai MHQ were analyzed. Responsiveness was determined using the standardized response mean (SRM).

Results

Minor modification of the Thai version was made to better explain the term “tingling”. The Thai BCTQ-S, Thai BCTQ-F and Thai BCTQ demonstrated adequate Cronbach’s alpha values (0.91-0.94) and good test-retest reliability (ICC=0.89-0.98). Regarding related dimensions, a strong correlation (r=0.67, P<0.008) was found between the Thai BCTQ-F and the Function subscale of Thai MHQ as well as between Thai BCTQ-F and the Activities of Daily Living subscale of the Thai MHQ (r=0.75, P<0.008). In unrelated dimensions, there was a relatively weak correlation between the Thai BCTQ-S and the Aesthetics subscale of the Thai MHQ (r=0.32, P=0.0116). The SRM of the Thai BCTQ was 1.46, indicating large responsiveness.

Discussion

The Thai BCTQ has adequate internal consistency in both the symptom and function scales as well as good construct validity and test-retest reliability indicating it is suitable for evaluating Thai CTS patients. This tool also has a high ability to detect clinically significant changes in symptoms and function over time after receiving conservative or surgical treatment.
Comparative efficacy of three Bayesian variable selection methods in the context of weight loss in obese women
Authors: Pesenti Nicola , Quatto Piero , Colicino Elena , Cancello Raffaella , Scacchi Massimo , Zambon Antonella
Published: July 2023

The use of high-dimensional data has expanded in many fields, including in clinical research, thus making variable selection methods increasingly important compared to traditional statistical approaches. The work aims to compare the performance of three supervised Bayesian variable selection methods to detect the most important predictors among a high-dimensional set of variables and to provide useful and practical guidelines of their use. We assessed the variable selection ability of: (1) Bayesian Kernel Machine Regression (BKMR), (2) Bayesian Semiparametric Regression (BSR), and (3) Bayesian Least Absolute Shrinkage and Selection Operator (BLASSO) regression on simulated data of different dimensions and under three scenarios with disparate predictor-response relationships and correlations among predictors. This is the first study describing when one model should be preferred over the others and when methods achieve comparable results. BKMR outperformed all other models with small synthetic datasets. BSR was strongly dependent on the choice of its own intrinsic parameter, but its performance was comparable to BKMR with large datasets. BLASSO should be preferred only when it is reasonable to hypothesise the absence of synergies between predictors and the presence of monotonous predictor-outcome relationships. Finally, we applied the models to a real case study and assessed the relationships among anthropometric, biochemical, metabolic, cardiovascular, and inflammatory variables with weight loss in 755 hospitalised obese women from the Follow Up OBese patients at AUXOlogico institute (FUOBAUXO) cohort.
Feeding on rapid cold hardening Ambrosia artemisiifolia enhances cold tolerance of Ophraella communa
Authors: Tian Zhenqi , Ma Chao , Zhang Yan , Chen Hongsong , Gao Xuyuan , Guo Jianying , Zhou Zhongshi
Published: July 2023

Low temperatures greatly influence newly introduced species, and increased cold tolerance can facilitate their establishment in new environments. The invasive alien species Ambrosia artemisiifolia is distributed at high latitudes and altitudes, where it suffers more from cold stress than it would at low latitudes or altitudes. Whether cold stress influences the accumulation of cryoprotectants and cold tolerance in A. artemisiifolia, and further influences the cold tolerance of its biological control agent, Ophraella communa, through feeding remain unknown. We investigated the levels of cryoprotectants and metabolic changes in A. artemisiifolia. We found that the level of total sugar, trehalose, proline, and other cold responsible metabolites increased in A. artemisiifolia after rapid cold-hardening (RCH) treatment, when compared to normal plants. These indicated that RCH treatment could improve the cold-hardiness of A. artemisiifolia. We then investigated the levels of cryoprotectants and metabolic changes in O. communa. We found that O. communa fed on RCH-treated A. artemisiifolia had higher levels of total sugar, trehalose, proline, glycerol, lipid, lower water content, lower super-cooling point, and increased cold tolerance compared to O. communa fed on normal A. artemisiifolia. This suggested that O. communa fed on cold-hardened A. artemisiifolia could increase its cold tolerance. Results showed a trophic transmission in insect cold tolerance. Our study enriches the theoretical basis for the co-evolution of cold tolerance in invasive and herbivorous insects.
Comparative transcriptome profiling provides insights into the growth promotion activity of Pseudomonas fluorescens strain SLU99 in tomato and potato plants
Authors: Hanifah Nurul Atilia Shafienaz binti , Ghadamgahi Farideh , Ghosh Samrat , Ortiz Rodomiro , Whisson Stephen C. , Vetukuri Ramesh R. , Kalyandurg Pruthvi B.
Published: July 2023

The use of biocontrol agents with plant growth-promoting activity has emerged as an approach to support sustainable agriculture. During our field evaluation of potato plants treated with biocontrol rhizobacteria, four bacteria were associated with increased plant height. Using two important solanaceous crop plants, tomato and potato, we carried out a comparative analysis of the growth-promoting activity of the four bacterial strains: Pseudomonas fluorescens SLU99, Serratia plymuthica S412, S. rubidaea AV10, and S. rubidaea EV23. Greenhouse and in vitro experiments showed that P. fluorescens SLU99 promoted plant height, biomass accumulation, and yield of potato and tomato plants, while EV23 promoted growth in potato but not in tomato plants. SLU99 induced the expression of plant hormone-related genes in potato and tomato, especially those involved in maintaining homeostasis of auxin, cytokinin, gibberellic acid and ethylene. Our results reveal potential mechanisms underlying the growth promotion and biocontrol effects of these rhizobacteria and suggest which strains may be best deployed for sustainably improving crop yield.
Metabolomic and transcriptomice analyses of flavonoid biosynthesis in apricot fruits
Authors: Chen Yilin , Li Wenwen , Jia Kai , Liao Kang , Liu Liqiang , Fan Guoquan , Zhang Shikui , Wang Yatong
Published: July 2023

Introduction

Flavonoids, as secondary metabolites in plants, play important roles in many biological processes and responses to environmental factors.

Methods

Apricot fruits are rich in flavonoid compounds, and in this study, we performed a combined metabolomic and transcriptomic analysis of orange flesh (JN) and white flesh (ZS) apricot fruits.

Results and discussion

A total of 222 differentially accumulated flavonoids (DAFs) and 15855 differentially expressed genes (DEGs) involved in flavonoid biosynthesis were identified. The biosynthesis of flavonoids in apricot fruit may be regulated by 17 enzyme-encoding genes, namely PAL (2), 4CL (9), C4H (1), HCT (15), C3’H (4), CHS (2), CHI (3), F3H (1), F3’H (CYP75B1) (2), F3’5’H (4), DFR (4), LAR (1), FLS (3), ANS (9), ANR (2), UGT79B1 (6) and CYP81E (2). A structural gene-transcription factor (TF) correlation analysis yielded 3 TFs (2 bHLH, 1 MYB) highly correlated with 2 structural genes. In addition, we obtained 26 candidate genes involved in the biosynthesis of 8 differentially accumulated flavonoids metabolites in ZS by weighted gene coexpression network analysis. The candidate genes and transcription factors identified in this study will provide a highly valuable molecular basis for the in-depth study of flavonoid biosynthesis in apricot fruits.