bluuebunny/crossref_metadata_2025 huggingface dataset:
Indicadores de desempenho e performance em sistemas de gestão em saúde e segurança do trabalho: uma revisão sistemática de literatura
Authors: Veloso Fracasso Bruno , De Souza Libânio Cláudia , Gonçalves Amaral Fernando
Published: April 2022

Acidentes de trabalho, lesões e doenças ainda são sérios problemas nas organizações, as taxas mostram que, apesar dos esforços para conter esses eventos, acidentes ainda estão acontecendo nas indústrias, com todos os custos implicados para as empresas. A norma ISO 45001:2018 surge no cenário internacional com o objetivo principal de prevenir os riscos ocupacionais e aqueles relacionados à saúde dentro das organizações, apostando na melhoria contínua através da padronização de um Sistema de Gestão de Saúde e Segurança no Trabalho (SGSST). A esses sistemas são atrelados resultados que geram efeitos positivos ao serem introduzidos em uma organização, impactando tanto na segurança quanto na produtividade. A presente revisão sistemática teve como objetivo definir os indicadores e os resultados referentes à implantação de SGSST através da OHSAS 18001 e ISO 45001, buscando apontar os indicadores referentes aos SGSST, categorizar tais indicadores e comparar qual SGSST opera melhor. Trata-se de uma revisão sistemática de literatura que utiliza o protocolo PRISMA (Gul, M., 2018), sendo assim, definindo um fluxo com quatro fases para a busca dos estudos selecionados a partir de sua identificação, seleção, elegibilidade até a inclusão. Nesta pesquisa, foram aplicados critérios de inclusão e exclusão em 344 artigos, restando 28 estudos que compuseram a presente revisão. Por tratar-se de uma norma relativamente nova, foram poucos os artigos revisados que avaliassem os indicadores a partir da ISO 45001. A partir da revisão realizada, foi possível constatar que os indicadores para acompanhar a performance dos SGSST devem estar alinhados às práticas da empresa, além disso, foram vistos que os resultados advindos da implantação de um SGSST estarão atrelados ao quanto a empresa envolve-se com o sistema. O persente trabalho mostra-se fundamental para o entendimento de como sistemas de gestão em saúde e segurança no trabalho devem ser acompanhados através de métricas que, por muitas vezes, já são instituídas pelas corporações.
Palavras-Chave: ISO45001:2018; Sistemas de Gestão de Saúde e Segurança no Trabalho; Indicadores.
Instrumentos econômicos no licenciamento ambiental: a garantia bancária autônoma prevista na Resolução CONAMA nº 001/2019 (Niterói, RJ)
Authors: Moreira Ferreira Juliana , da Costa Silva Lívia Maria , Vianna Pereira Luciana
Published: April 2022

A variedade de produtos provenientes da indústria de óleo e gás, assim como a importância econômica e social que possuem, torna a atividade extrativista essencial para a economia brasileira. Contudo, a operação do setor gera registros recorrentes de acidentes ambientais e muitos ocasionam danos significativos aos ecossistemas e às comunidades locais. Por mais que o Brasil possua legislação ambiental robusta, percebe-se a necessidade de novas ferramentas de proteção ao meio ambiente. Considerando a problemática, o presente artigo tem como objetivo abordar um instrumento financeiro alternativo atrelado ao licenciamento ambiental: a Garantia Bancária Autônoma (GBA) em primeira solicitação. Para tal, apresenta-se primeiramente uma análise dos métodos de proteção ambiental vigentes em legislação e, em seguida, a normativa que trata da GBA na Reserva Extrativista Marinha de Itaipu - RESEX Itaipu, no município de Niterói, Rio de Janeiro, aplicada à operação da indústria de óleo e gás. Ao longo do trabalho percebe-se que, por mais que seja evidenciada a importância desse instrumento econômico e suas vantagens, nota-se a necessidade de maior estudo a respeito, pois há empecilhos para sua maior aplicação, tanto no que diz respeito ao seu funcionamento quanto a sua aplicação jurídica.
Palavras-Chave: Meio ambiente; Garantia Bancária; Seguro; Prevenção; Danos.
Planejamento estratégico ambiental e indicadores de sustentabilidade: estudo bibliométrico de 2009 a 2021 na produção acadêmica
Authors: Silva Thamirys Suelle da , Silva Kardelan Arteiro da , El-Deir Soraya Giovanetti
Published: April 2022

Com o desafio de tornar cada vez mais amplo o desenvolvimento sustentável, são necessários estudos que possam disseminar a compreensão da gestão ambiental voltada para o planejamento estratégico ambiental. Com isso, realizar uma gestão de sustentabilidade por meio de indicadores terá repercussão na elevação da qualidade ambiental e de parâmetros socioeconômicos das empresas e instituições. Objetivo: fornecer uma revisão e análise do conhecimento relacionado ao planejamento estratégico ambiental através de indicadores sustentáveis na produção acadêmica científica. Trata-se de pesquisa exploratória descritiva. Com revisão de artigos na plataforma ScienceDirect por meio da sistematização de etapas, buscando identificar os indicadores de sustentabilidade e planejamento estratégico ambiental por meio das produções científicas. Em seguida, foi realizada a bibliometria, empregando-se uma abordagem qualiquantitativa, buscando a avaliação das produções científicas no período de 2010 a 2021. Avaliou-se um aumento na produção científica, principalmente nos anos de 2016 a 2018, evidenciando o eixo temático abordado na pesquisa, apresentando uma tendência de crescimento nos números de artigos no período de 10 anos. O continente Europeu representara 62,8% das pesquisas científicas publicadas voltadas para indicadores de sustentabilidade e planejamento estratégico ambiental. Outro fator relevante foi em relação às classes analisadas que mostraram o quão intensamente os vocabulários estão semelhantes entre os tratamentos dos dados. Com vistas aos resultados, os estudos sobre o planejamento estratégico ambiental, os quais devem ser analisados e estudados para melhor compreensão dos processos, buscando auxiliar e nortear as tomadas de decisões, quando direcionadas para as questões sustentáveis.
Palavras-Chave: Estratégia ambiental; Gestão ambiental; Operacional; Práticas sustentáveis.
Understanding Musculoskeletal Disorders Through Next-Generation Sequencing
Authors: Garg Bhavuk , Tomar Neeraj , Biswas Amitabh , Mehta Nishank , Malhotra Rajesh
Published: April 2022

» An insight into musculoskeletal disorders through advancements in next-generation sequencing (NGS) promises to maximize benefits and improve outcomes through improved genetic diagnosis.

» The primary use of whole exome sequencing (WES) for musculoskeletal disorders is to identify functionally relevant variants.

» The current evidence has shown the superiority of NGS over conventional genotyping for identifying novel and rare genetic variants in patients with musculoskeletal disorders, due to its high throughput and low cost.

» Genes identified in patients with scoliosis, osteoporosis, osteoarthritis, and osteogenesis imperfecta using NGS technologies are listed for further reference.
Percepción del tamaño corporal actual y deseado en la niñez temprana
Authors: León González María Pilar , González-Martí Irene , López Sánchez Guillermo Felipe , Contreras Jordán Onofre Ricardo
Published: April 2022

La imagen corporal es un constructo de relevancia social dada su repercusión en la salud física y mental. La investigación de este constructo en edades tempranas ha recibido escasa atención a pesar de que algunos autores han demostrado que existe preocupación hacia el cuerpo en edad preescolar. Este estudio de diseño mixto tuvo como objetivo medir la percepción del tamaño corporal, el cuerpo deseado y la insatisfacción corporal en niños de edad temprana. Para ello, se utilizó la Escala Corporal para Preescolares, compuesta de cuatro figuras de niños con diferentes estados de peso, la cual fue administrada a 176 participantes de 4 y 5 años, de los cuales 96 fueron chicos y 80 fueron chicas. Los resultados mostraron que la percepción del tamaño corporal fue inexacta en ambos sexos y edades, tendiendo hacia una mayor sobreestimación en las niñas. También se observó que la mayoría de los participantes eligieron una figura deseada diferente a la percibida, especialmente el sexo femenino. Sin embargo, este hallazgo no necesariamente reflejaría la existencia de insatisfacción corporal, como sugieren los datos cualitativos. Las respuestas de los participantes parecen reflejar una ligera conciencia corporal. Se necesitan futuros estudios que ahonden más en el desarrollo de la imagen corporal en edades tempranas.
Víctimas de cyberbullying y su influencia en las Dificultades de Regulación Emocional en adolescentes del Ecuador
Authors: Moya-Solís Adriana , Moreta-Herrera Rodrigo
Published: April 2022

Introducción: El cyberbullying es un fenómeno de acoso entre pares que provoca efectos emocionales en las víctimas. Objetivo: Identificar la prevalencia de víctimas de cyberbullying y de Dificultades de Regulación Emocional, así como la relación y la predictibilidad en una muestra de adolescentes del Ecuador. Método: Estudio descriptivo correlacional y explicativo. Participantes: 904 adolescentes (53.5% mujeres y 46.5% hombres) con edades entre 15 a 18 años (M = 16.6 años; DT = 1.15), estudiantes de nueve ciudades del Ecuador. Resultados: La prevalencia de víctimas consolidadas de cyberbullying es baja (3%) y un 82% de casos que reportan ataques al menos una vez en la vida, mientras que en las Dificultades de Regulación Emocional existe presencia baja moderada con 9.3% de casos de riesgo. Existe relación moderada y positiva entre el Cyberbullying-victimización y las Dificultades de Regulación Emocional. El Cyberbullying-victimización explica en un 22.8% los cambios en la varianza de las Dificultades de Regulación Emocional a través de un modelo de ajuste adecuado. Conclusiones: La victimización por cyberbullying es un predictor importante en el desarrollo de Dificultades de Regulación Emocional en adolescentes del Ecuador, lo que permite identificar el efecto del acoso en las emociones.
¿Qué convierte a una persona en líder? El papel de la inteligencia emocional, la capacidad de trabajo en equipo y la satisfacción laboral en el liderazgo auténtico
Authors: Conejero-Pérez José-Ignacio , López-Verdugo Isabel , Hidalgo Victoria
Published: April 2022

Las razones por las que una persona llega a convertirse en un buen líder trascienden el ámbito empresarial y laboral. Los estudios actuales avalan la importancia de las dimensiones personales en el desarrollo del liderazgo. El objetivo del trabajo es analizar el papel de variables personales como la inteligencia emocional, la capacidad de trabajo en equipo y la satisfacción laboral en el desempeño de un liderazgo auténtico. La muestra estuvo conformada por 964 participantes en un proceso de selección de personal (edad, M = 36.37, DT = 8.87). Se realizaron análisis de regresión lineal múltiple para determinar la influencia de la inteligencia emocional, el trabajo en equipo y la satisfacción laboral en el liderazgo auténtico, así como análisis de moderación y mediación. Los resultados obtenidos apoyan la existencia de relaciones entre las variables incluidas en el estudio. Se ha encontrado que la inteligencia emocional, el trabajo en equipo y la satisfacción laboral explican una parte sustancial de la variabilidad en el liderazgo auténtico; así como diferentes relaciones de mediación y moderación. Los resultados obtenidos son discutidos destacando el papel de las variables personales analizadas tanto en los procesos de selección como de formación para el fortalecimiento y el logro de un verdadero liderazgo auténtico.
Optimization of reach-scale gravel nourishment on the Green River below Howard Hanson Dam, King County, Washington
Authors: Corum Zachary , Cheng Ethan , Gibson Stanford , Dahl Travis
Published: April 2022

The US Army Corps of Engineers, Seattle District, nourishes gravel downstream of Howard Hanson Dam (HHD) on the Green River in Washington State. The study team developed numerical models to support the ongoing salmonid habitat improvement mission downstream of HHD. Recent advancements in computing and numerical modeling software make long-term simulations in steep, gravel, cobble, and boulder river environments cost effective. The team calibrated mobile-bed, sediment-transport models for the pre-dam and post-dam periods. The modeling explored geomorphic responses to flow and sediment regime changes associated with HHD construction and operation. The team found that pre-dam conditions were significantly more dynamic than post-dam conditions and may have had lower spawning habitat quality in the project vicinity. The team applied the Bank Stability and Toe Erosion Model to the site and then calibrated to the post-dam gravel augmentation period. The team implemented a new hiding routine in HEC-RAS that improved the simulated grain size trends but underestimated coarse sediment transport. Models without the hiding function overestimated grain size but matched bed elevations and mass flux very well. Decade-long simulations of four future gravel nourishment conditions showed continued sediment storage in the reach. The storage rate was sensitive to nourishment mass and grain size.
Quality assessment of used edible fats and oils by local vendors of Faisalabad
Authors: Ahmed Waqar
Published: April 2022

Fats and oils are both economically and scientifically important in food systems and play an important role in nutrition. The principal causes of fat degradation are oxidation and hydrogenation, which have a detrimental impact on quality aspects of oils and fats such as color, texture, flavor, aroma, consistency, and appearance. The current research was conducted to determine the oil degradation factors by collecting fifty samples of fried oils used by street vendors from twenty-five different locations in Faisalabad area in order to assess the quality parameters of locally available fats and oil products. Procured samples underwent physicochemical tests to determine the degree of degradation and oxidation. The parameters analyzed for quality evaluation include free fatty acids (FFA), peroxide value (PV), iodine value (IV), saponification value (SV), viscosity, refractive index (RI), p-anisidine value (p-AV), thiobarbeturic acid value (TBA), specific gravity (SG) and fatty acid profile through gas chromatograph equipped with flame ionization detector. The analyses revealed significant oxidation and degradation in many of the vendor fried fats and oil that were procured. Physicochemical characteristics as well as oxidative stability attributes were deviated from the standard values defined by Codex Alimentarius and Punjab Pure Food Regulations (PPFR). In majority of the samples, the fatty acid profile exhibited increased levels of trans-9-elaidic acid and linolelaidic acid, indicating the presence of trans-fatty acid because of hydrogenation and high-temperature frying of fats and oils. The overall quality of most procured samples was in decline from recommended standards and unsuitable for frying and edible purposes
Evaluation of eggplant genotypes and coat protein cistron based characterization of cucumber mosaic virus eggplant isolates of subgroup IB from Pothwar region of Pakistan
Authors: Ashfaq Muhammad
Published: April 2022

Cucumber mosaic virus (CMV) is a destructive and menace to a wide range of plant species including eggplant crop worldwide. This study was carried out to define the current status of CMV infecting eggplant crop in Pothwar region of Pakistan and characterization of CMV eggplant isolates as well as to recognize the sources of resistance in eggplant genotypes. A total of 660 leaf samples with the virus and virus-like symptoms were collected from different sites of Pothwar region and subjected to CMV specific DAS-ELISA using monoclonal antibodies. ELISA results indicated that approximately 56% of samples were positive for CMV infection and the disease incidence was highest (62.50%) in Jhelum district followed by Rawalpindi (58.33%), Chakwal (58.33%) and Attock (55.55%) districts with the lowest disease incidence (46.15%) was recorded in Islamabad district. Two ELISA positive samples from each district were further confirmed by RT-PCR and subsequently sequenced based on their coat protein cistron. All isolates were identical to each other so the nucleotide sequence of one eggplant isolate (CMV-Pak) was deposited in GenBank with accession number MH119063. BLAST and phylogenetic analysis revealed that CMV-Pak eggplant isolate shared 90-94% nucleotide and 80-100% amino acid similarities with other isolates available in GenBank. Moreover, 10 eggplant genotypes were tested against CMV-Pak eggplant isolate, ELISA results categorized three genotypes (Singh Nath 666, Neelum, and Brinjal Jamak) as moderately resistant, two genotypes (Round Black, and Global Brinjal PPL) as susceptible and rest of the five genotypes (Bemissal, Brinjal Shilpa, Short Purple, Brinjal PPL, and Namyal Ratchburi) as moderately susceptible. Therefore, the three moderately resistant genotypes could be recommended to farmers for farming and plant breeders for developing new eggplant resistant genotypes to CMV. To the best of our knowledge, this study is the first time provided evidence that CMV infects eggplant in Pakistan.
Preliminary evaluation of halotolerant PGPRs for promoting maize growth under salt stressed gnotobiotic conditions
Authors: Shabaan Muhammad
Published: April 2022

Salinity stress is one of the critical factors that limits agricultural productivity particularly in the arid to semi-arid regions worldwide. Elevated concentrations of soluble salts especially NaCl cause osmotic stress, ionic stress and imbalance in the uptake of essential nutrients. Use of salt tolerant rhizobacterial isolates have gained much attention now-a-days on account of their environment friendly nature and effectiveness. Therefore, current study was executed to isolate salt tolerant bacteria from the rhizosphere of maize and check their salt tolerance and plant growth promotion under salinity stress. Selected isolates were further investigated in a growth room trial to compare their efficiency in improving growth and physiology of maize. Salinity stress caused a significant reduction in all the measured traits however, inoculation of rhizobacteria modulated its effects and improved maize growth. Among different strains, SUA-14 caused maximum increment in the shoot length (41%), root length (96%), shoot fresh (1.8 fold) and dry weight (1.3 fold), root fresh (1.76 fold) and dry weight (2 fold), salt tolerance index (1.6 fold), chl ‘a’ contents (2.6 fold) and chl ‘b’ contents (2.3 fold) as compared to its respective uninoculated control. Whereas, rhizobacterial strain SHM-5, SHM-13 and SUA-14 showed statistically nonsignificant response in terms of increasing carotenoid contents by 1.8 fold in comparison with their corresponding control. Pearson correlation coefficient showed a strong positive correlation between growth and physiological attributes under salinity stress. On the basis of PCA, SUA-14 found to be the most efficient strain followed by SHM-13. Using 16 S rRNA sequencing, SUA-14 and SHM-13 were identified as Acinetobacter and Bacillus species respectively.
Deoiling Hydrocyclones: An Experimental Study of Novel Control Schemes
Authors: Mishiga Vallabhan K G , Holden Christian , Skogestad Sigurd
Published: April 2022

Deoiling hydrocyclones are compact, passive devices commonly used for produced-water treatment (PWT) for oil production. The oily water enters the tangential inlet of the hydrocyclone and gets separated such that cleaned water comes out as a water-reject (underflow) stream, and concentrated oil comes out as an oil-reject (overflow) stream. For control purposes, the pressure drop ratio (PDR) across the inlet and the two outlets may be kept constant to maintain separation in the presence of disturbances. However, the PDR control scheme does not effectively reject some disturbances, such as changes in the inlet oil concentration and inlet droplet distribution. This paper proposes three novel control schemes to improve the separation with the aim to limit the oil concentration at the water reject at 30 ppm. The control schemes use concentration measurements from online oil-in-water analyzers at the inlet and water-reject (underflow) outlet. Two control schemes (a feedforward and a feedback/cascade) are used as a supervisory layer to the existing PDR control scheme. The third control scheme directly manipulates the final control element (valve position) to maintain the separation of the hydrocyclones. This paper gives experimental results to validate all three control schemes when subjected to disturbances such as changes in inflow rate, inlet oil concentration, and inlet droplet distribution.
Design of and Outcomes in a Student-Run Free Mental Health Clinic Serving the Uninsured in East Harlem
Authors: Powell Samuel K , Saali Alexandra , Frere Justin , Magill Elizabeth , Krystal Hannah , Serafini Randal , Sultana Syeda , Dale Brandon , Ali Muhammad , Kumar Vedika , Datta Debjyoti , Hernandez-Antonio Josimar , Aronson Anne , Meah Yasmin , Gluhoski Vicki , Katz Craig
Published: April 2022

Background
Safety-net clinics are an important source of low-cost or free mental healthcare to those with limited financial resources. Such clinics are often staffed by trainees in early stages of their career. Only limited data exists on best practices in treatment-implementation and on clinical outcomes attained in such clinics. The primary purpose of this article is to describe the design of a student-run free mental health clinic serving uninsured individuals in New York City’s East Harlem neighborhood and to analyze the quality of services provided and the clinical outcomes attained.
Methods
The authors conducted a retrospective chart review of n=69 patients treated in the EHHOP Mental Health Clinic (E-MHC). Utilizing Health Effectiveness Data and Information Service metrics, they estimated the likelihoods of patients meeting metric quality criteria compared to those in other New York State (NYS) insurance groups. The authors derived linear mixed effect and logistic regression models to ascertain factors associated with clinical outcomes. Finally, the authors report on feedback provided by the patients collected via a customized survey.
Results
The clinical service performance of the E-MHC was non-inferior on most measures examined. The E-MHC underperformed NYS HMO clinics in the provision of acute-phase antidepressant medication management; the authors did not find any performance differences in continuation-phase antidepressant management. Additionally, the E-MHC outperformed NYS commercial and Medicaid plans on optimal provider contacts for depression and follow-up care after ED visit for alcohol or other drugs within 30 days. Factors associated with symptom improvement were number of treatment sessions and certain demographic and clinical variables. Patients provided highly positive feedback on the care they received.
Conclusions
SRFCs can provide quality care to vulnerable patients that leads to clinically meaningful reductions in psychiatric symptoms and is well-received by patients.
JQ1 attenuates neuroinflammation by inhibiting the inflammasome-dependent canonical pyroptosis pathway in SAE
Authors: Zhong Xiaolin , Chen Zuyao , Wang Yajuan , Mao Mingli , Deng Yingcheng , Shi Mengmeng , Xu Yang , Chen Ling , Cao Wenyu
Published: April 2022

Sepsis-associated encephalopathy (SAE) manifests clinically in hyperneuroinflammation. Pyroptosis, which can induce an inflammatory cascade response, has been considered to be a causative factor of SAE. Evidence has shown that the bromo- and extraterminal (BET) proteins (including BRD2, BRD3, BRD4 and BRDT) inhibitor JQ1 can inhibit inflammation and suppress pyroptosis in various diseases. Therefore, we examined the effect of JQ1 on inflammasome-induced pyroptosis in the hippocampus in a mouse model of sepsis induced by lipopolysaccharide (LPS) injection. The results showed that JQ1 treatment alleviated sepsis-related symptoms, protected the blood–brain barrier (BBB), as indicated by upregulated expression of the tight junction proteins occludin and ZO-1, and remarkably rescued neuronal damage in SAE mice. Mechanistically, we demonstrated that JQ1 intervention inhibited the expression of BRD proteins and decreased the expression of inflammasomes by blocking nuclear factor kappa B (NFκB) signalling, attenuating the canonical pyroptosis (mediated by cleaved-Caspase1/11) pathway and the release of proinflammatory factors in the hippocampus of septic mice. Interestingly, we also found that JQ1 selectively suppressed the activation of hippocampal microglia in SAE mice. Thus, JQ1 protected the hippocampal BBB and neuronal damage through the attenuation of neuroinflammation by inhibiting the inflammasome-dependent canonical pyroptosis pathway induced by LPS injection in mice, and JQ1 may be a promising target for the prevention of SAE.
Placental DNA methylation changes in the development of gestational diabetes mellitus
Authors: Chen Fujia , Li Min , Fei Xiaoping , Zhu Weiqiang , Zhang Zhaofeng , Shen Yupei , Mao Yanyan , Zhu Qianxi , Xu Jianhua , Zhou Weijin , Du Jing
Published: April 2022

Aims
The aim of this study was to investigate the association between gene methylation alterations and the development of GDM, as well as to investigate the potential epigenetic mechanisms of GDM.
Methods
Reduced representation bisulfite sequencing (RRBS) and RNA sequencing (RNA-seq) analysis were performed on placental tissues from women with GDM and healthy controls. After pyrosequencing, correlation and linear regression analysis were applied based on the effect of methylated-differentially expressed genes (DEGs).
Results
HOXD9, ALDH1A2, CSMD1, TRIM67, and PAX8, five candidate DEGs, were identified. TRIM67 exhibited significant hypermethylation levels at different CpG sites. Hypermethylation of TRIM67 promoter was significantly positively correlated with 1h and 2h OGTT glucose levels and negatively correlated with Lipoprotein(a).
Conclusions
TRIM67 hypermethylation in the placenta of women with GDM may correlate with insulin resistance, which may play a role in the development of GDM. These findings provide new insights for further studies on the pathophysiology of GDM.
Cutaneous fistula, a rare presentation of squamous cell carcinoma of the renal pelvis
Authors: abdelkader abdelrahman
Published: April 2022

Background : Renal cell carcinoma with all its variants represent more than ninety percent, the remaining ten percent is divided on urothelial tumors, sarcomas and metastasis from other organs. Squamous cell carcinoma of the renal pelvis is mentioned very few due to its rarity. Until now there is no guideline for managing it unlike transitional cell carcinoma. Our case is very rare, one or two case all over the world has been reported to our knowledge, also the treatment plan which was salvage surgery was very successful. Case presentation: This article will discuss a male patient who developed squamous cell carcinoma in the renal bed after nephrectomy, managed with excellent outcome in Assiut university hospital. After 8 month the patient show good and excellent performance. Conclusions : The general rule of this type of malignancy is that it is resistant to both chemo and radiotherapy with good outcome to surgery if early intervention was done. Our case could provide a beacon for similar cases.
Nursing assistant’s knowledge, attitude and training demands toward urinary incontinence in nursing homes: A mixed methods study
Authors: Liao Lulu , Jiao Jingjing , Zhao Yinan , Ning Hongting , Feng Hui
Published: April 2022

Background: Urinary incontinence is an increasingly common problem, especially the older people. Nursing assistants are the main force in nursing homes. Their knowledge and attitude about urinary incontinence is attracting considerable critical attention. However, most previous studies have focused on nurses in hospital. This study set out to figure out the nursing assistants’ training needs concerning urinary incontinence.Methods：We conducted a two-part mixed-methods study. A survey on the knowledge and attitude of nursing assistants about urinary incontinence was undertaken (n=509). Then, semi-structured interviews were used to elicit detail training demands (n=40). Results：In general, urinary incontinence knowledge was poor (14±4.18), while attitudes were mostly positive (35.51±3.19). The nursing assistants are very interested in learning more about urinary incontinence. The variety of preferred learning methods emphasizes the need for diversified educational materials.Conclusions：Urinary incontinence is an effective indicator of care quality in nursing homes. The managers should formulate targeted training courses and preferred training forms suitable for the nursing homes.
Prevalence of Psychological Khat Dependency and It’s Associated Factors Among Mettu University Students, Southwest Ethiopia, 2021
Authors: Efrem Mesfin , Mulat Haregewoyn , Kassew Tilahun , Minichil Woredawu
Published: April 2022

Introduction: It is estimated that 5 to 10 million people worldwide chew Khat, the majority of whom live in the Horn of Africa and the Arabian Peninsula, particularly Ethiopia, Somalia, and Yemen. Chewing khat is a part of life for a vast majority of the people in these countries. Excessive and long-term khat use has the potential to cause psychological dependency with a prominent feature akin to amphetamine-type stimulant dependence. The goal of this study was to determine the prevalence of psychological khat addiction and the factors that contribute to it among Mettu University students. Methods: institution based cross-sectional study was conducted from April 01/2021 – April 29/,2021at Mettu University. The study sample was recruited through Stratified multistage sampling technique (n = 1046). Structured English version self-administered questionnaire were used to collect data on socio-demographic factors, habit of khat use and other variables. The data were edited, cleaned, coded and entered in to Epi-data version 4.6.02 then it was exported to Stata/SE 14.0. Binary and multivariable logistic regressions were used to identify sociodemographic factors and other substance-use related factors that are associated with psychological khat dependency. Results were interpreted and presented in the form of table, figures & chart. Result: Among the original 1046 participants 1001 of them were clearly fill and respond the questionnaire but only157 of current khat chewer were included in the analysis process since the target of the study was to study dependency on khat. The results of the other 1001 respondents were simply reported descriptively through table and diagram. Among 157 current khat chewers 47.7% (95% CI: 39.9–55.6) of them were found dependent on khat based on SDS score whether the left 52.23% respondents were not khat dependent. Among those found dependent the amount of khat chewed each session (AOR; =6.72, 95% CI’ =2.17–20.78), duration of chewing khat in each session (AOR; =4.2, 95% CI; =1.43–12.73), days chewing khat per week (AOR; =4.2, 95% CI; =1.39–12.96), depression (AOR; =4.08, 95% CI; =1.40–11.9), cigarrete smoking (AOR; =3.5, 95% CI; =1.0032–12.37), poor social support (AOR; =4.4, 95% CI; =1.34–14.43) and 4th year and above (AOR; =3.65, 95% CI; =1.07–12.49) were show significance association with khat dependency both in bivariate and multivariate analysis. Conclusion: khat chewing has a psychological dependence effect on those who use khat for prolonged time, chewing large amount of khat and those who chew khat frequently, Therefore, it calls for a strong multi sectorial involvement including local administrative bodies, health services providers, and non-governmental organizations.
Design of 2D Photonic Crystal Biosensor to Detect Blood Components
Authors: Parandin Fariborz , heidari farsad , Aslinezhad Mehdi , Roshani Sobhan , Roshani Saeed
Published: April 2022

Photonic crystals are periodic structures made of insulators. They are the best option to design biosensors. In this paper, a photonic crystal biosensor containing insulation rods in the air was designed and simulated. This biosensor was used as a photonic crystal circular nano-ring between the internal and external waveguides. At the end of the internal waveguide, a defect exists to create an increase in the coupling distance. This causes the quality factor and resonant wavelength displacement to increase. The purpose of designing this sensor is to check blood ingredients. After connecting to a measuring rod, this sensor shows different refractive indices. Another important characteristic of the proposed structure is that mostly radiuses of dielectric rods are identical. This causes the sensor construction to be easy. The plane-wave expansion (PWE) method is utilized to calculate the band structure. The results show that a photonic band gap (PBG) with a wavelength from 1.26 \(\mu m\) to 1.92 \(\mu m\) is created in this distance where no wavelength can spread.
Using a graph-based image segmentation algorithm for remote vital sign estimation and monitoring
Authors: Yang Xingyu , Zhang Zijian , Huang Yi , Zheng Yalin , Shen Yaochun
Published: April 2022

Reliable and contactless measurements of vital signs, such as respiration and heart rate, are still an unmet need in clinical and home settings. Mm-wave radar and video-based technologies are promising, but currently, the signal processing-based vital sign extraction methods are prone to body motion disruptions or illumination variations in the surrounding environment. Here we propose an image segmentation-based method to extract vital signs from the recorded video and mm-wave radar signals. The proposed method analyses time-frequency spectrograms obtained from Short-Time Fourier Transform rather than individual time-domain signals. This leads to much-improved robustness and accuracy of the heart rate and respiration rate extraction over existing methods. The experiments were conducted under no- and post-exercise conditions and repeated on multiple individuals. The results are evaluated by using four metrics against the gold standard contact-based measurements. Significant improvements are observed in terms of precision, accuracy, and stability. We believe that the proposed estimation method will help address the need for the increasingly popular remote cardiovascular sensing and diagnosing posed by Covid-19.
Analysis of the Mediating Role of Psychological Empowerment between Perceived Leader Trust and Employee Work Performance
Authors: LIU Xiaoli , REN Xiaopeng
Published: April 2022

High levels of trust between employees and leaders moderate the relationship between organizational management practices. A collaborative environment encourages employees to have more Psychological Empowerment, which in turn leads to better performance. Based on Intrinsic Work Motivation and Self-Evaluation, this paper uses Perceived Leader Trust as an independent variable, Employee Work Performance as a dependent variable, and introduces Psychological Empowerment to explore the internal mechanism of perceived trust. This paper proposes a total of 28 hypotheses, and 25 hypotheses have been verified. The specific research conclusions are as follows: (1) Perceived Leader Trust has a positive impact on Employee Work Performance. (2) Perceived Leader Trust positively affects employees' Psychological Empowerment. Perceived Leader Dependence has a significant impact on all dimensions of Psychological Empowerment, but the relationship between Perceived Information Disclosure and Work Meaning is not significant. (3) Psychological Empowerment is positively correlated with Employee Work Performance, in which the four dimensions of Psychological Empowerment are significantly related to Employee Task Performance, while Work Meaning and Autonomy are not significantly related to Employee Relationship Performance. (4) Psychological Empowerment, as the overall perception of employees, plays a partial mediating role between Perceived Leader Trust and Employee Work Performance. This paper verifies the role of Psychological Empowerment between Perceived Leader Trust and Employee Work Performance, and explores the internal mechanism of Perceived Leader Trust from the perspective of employees' Intrinsic Work Motivation, which promotes the development of organizational management practices.
Autotoxicity of Ambrosia artemisiifolia and Ambrosia trifida and its significance for the regulation of intra-species populations density
Authors: Su Pei , Liu Xuelian , Wang Ruili , Liu Tong , Zhao Wenxue , Sun Mingming , Wang Hanyue , Liu Yunxiao , Wu Qiang
Published: April 2022

Ambrosia artemisiifolia and Ambrosia trifida are annual invasive plants that cause serious harm to agriculture, animal husbandry, and human health. Based on the important characteristic of high-density, cluster distribution of their populations, it is speculated that its autotoxins have an effect on density regulation. This study explored the regulation of autotoxicity on intra-species density. We used water extracts from two plants to compare and verify the autotoxicity of seed germination, analysed the components of autotoxins. The results showed that A. artemisiifolia and A. trifida had significant autotoxicity, and the highest inhibition rates on seed germination were 27.21% and 77.94%, respectively; Ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS) analysis revealed that chlorogenic acid, caffeic acid, p-coumaric acid, and vanillin were the main autotoxins of the two plants. After the seeds were washed with water, the germination recovere rate of seeds increased with the increased of inhibition degree of autotoxins treatment. Therefore, this study verified the autotoxicity of A. artemisiifolia and A. trifida, which can promote and inhibit the seed germination of A. artemisiifolia and A. trifida to regulate intra-specific competition.
Epidermal Microbiomes of Leopard Sharks (Triakis semifasciata) Are Consistent Across Captive and Wild Environments
Authors: Goodman Asha Z. , Papudeshi Bhavya , Doane Michael P. , Johnson Colton , Mora Maria , Kerr Emma , Torres Melissa , Moffatt Jennifer , Lima Laís Farias Oliveira , Nosal Andrew , Dinsdale Elizabeth
Published: April 2022

Characterizations of sharks-microbe systems in wild environments have outlined patterns of species-specific microbiomes; however, whether captivity affects these trends has yet to be determined. We used high-throughput shotgun sequencing to assess the epidermal microbiome belonging to leopard sharks (Triakis semifasciata) in captive (Birch Aquarium, La Jolla California born and held permanently in captivity), semi-captive (held in captivity for <1 year in duration and scheduled for release; Scripps Institute of Oceanography, California) and wild environments (Moss Landing and La Jolla, California). Here we report captive environments do not drive epidermal microbiome compositions of T. semifasciata to significantly diverge from wild counterparts as life-long captive sharks maintain a species-specific epidermal microbiome resembling those associated with semi-captive and wild populations. Major taxonomic composition shifts observed were inverse changes of top taxonomic contributors across captive duration, specifically an increase of Pseudoalteromonadaceae and consequent decrease of Pseudomonadaceae relative abundance as T. semifasciata increased duration in captive conditions. Moreover, we show captivity did not lead to significant losses in microbial α-diversity of shark epidermal communities. Finally, we present a novel association between T. semifasciata and the Muricauda genus as Metagenomes associated genomes revealed a consistent relationship across captive, semi-captive, and wild populations. Since changes in microbial communities is often associated with poor health outcomes, our report illustrates that epidermally-associated microbes belonging to T. semifasciata are not suffering detrimental impacts from long or short-term captivity. Therefore, conservation programs which house sharks in aquariums are providing a healthy environment for the organisms on display. Our findings also expand on current understanding of shark epidermal microbiomes, explore the effects of ecologically different scenarios on benthic shark microbe associations, and highlight novel associations that are consistent across captive gradients.
Feasibility of a nonlinear spectral approach for peak floor acceleration of multi-story bilinear hysteretic buildings
Authors: Xiang Yang , Zhang Yu-Jian , Xu Fei , Li Guo-Qiang
Published: April 2022

To protect the acceleration-sensitive non-structural components in a multi-story building, a proper seismic design of them against the peak floor acceleration (PFA) is needed. The PFA, therefore, should be estimated in advance. To efficiently estimate the PFA of multi-story buildings at the inelastic stage, a nonlinear modal combination approach is provided in this study. First, for the single-story building (single-degree-of-freedom system), a PFA spectral ratio δ is proposed to measure the nonlinear reductions in PFA. A series of time history analysis (THA) revealed that there is a dependable relationship between the PFA spectral ratio δ, the strength reduction factor R, the post-yield stiffness ratio α, and the period T of the structure. The scatter of δ is notably smaller than the ductility demand, showing the good feasibility of a δ-R-T-α relationship for predicting δ. Second, for the multi-story building (multi-degree-of-freedom system), the floor acceleration is decoupled in the modal space, the contribution of each mode to the elastic PFA is multiplied by δ to account for the nonlinear reduction in PFA at the inelastic stage. Here δ can be determined by an appropriate δ-R-T-α relationship, while R and α are determined via a modal pushover analysis. The modified modal contributions are combined via the complete-quadratic combination (CQC) rule, forming the modified CQC (MCQC) approach. The PFAs of some 2-, 5-, and 8-story building structures with different degrees of nonlinearity are computed via the THA and the MCQC approach. The results demonstrate the satisfactory accuracy of the MCQC approach. Notably, the effects of nonlinearities associated with the higher-order modes on the nonlinear PFA are well considered in the MCQC approach, thus the un-acceptable over-estimations of the inelastic PFA, which occurs in conventional methods, are avoided.
Conjugates of Pyropheophorbide α with 17-substituted Steroidal Androgens. Synthesis, Molecular Modeling, Interaction with Some Cancer Cells
Authors: Zolottsev Vladimir , Korolchuk Andrei M. , Lukin Artyom S. , Morozevich Galina , Mekhtiev Arif R. , Novikov Roman. A. , Tkachev Yaroslav V. , Suvorov Nikita V. , Misharin Alexander Y. , Ponomarev Gelii V.
Published: April 2022

Five new bifunctional conjugates of pyropheophorbide a with 17-substituted testosterone, dihydrotestosterone and epitestosterone differing in the length of linker (1–5) and two new complex conjugates 6 and 7 (containing three functional units: pyropheophorbide a, 17α-substituted testosterone, and lipophylic hexadecyl chain) were synthesized. Mutual influence of steroidal and macrocyclic fragments in conjugates 1–7 was established by analysis of 1H NMR spectra and molecular models of conjugates. The uptake and internalization of conjugates 1–5 by prostate carcinoma cells were dependent on the stereochemical configuration of 17-hydroxyl group in steroidal moiety, and the length of linker. Conjugates 1–5 significantly decreased the LNCaP and PC-3 cells growth and proliferation at 96 h incubation; the anti-proliferative activity of epitestosterone derivative comprising short linker 3 was superior. Irradiation of cells labeled with conjugates with light (λ = 660 nm) significantly increased cytotoxicity. Trifunctioal conjugates 6 and 7 easily formed mixed micells with phosphatidyl choline and pluronic F68; these mixed micelles efficiently internalized by human hepatocarcinoma Hep G2 cells, herewith the internalization was dependent on the conjugate structure, rather than on the method of solubilization.
Effects of different doses of oxytocin on neonatal instinctive behaviors and breastfeeding: a prospective study
Authors: Wang Aihua , Zhou Yun , Liu Wenwen , Xu Yang , Zhang Xiaoyan , Miao Yiqun , Zhang Yuanyuan
Published: April 2022

Background: Oxytocin is the current domestic first-line agent of induced labor and labor augmentation, and its potential effects on neonatal neurobehavioral development is currently attracting increased attention.Objective: To explore the effect of different doses of synOT on neonatal instinctive breastfeeding behavior and breastfeeding by observing neonatal behaviors during SSC with mothers after delivery.Methods: A total of 154 pairs of pregnant women and their newborns were selected by random sampling. Observations and comparisons of neonatal instinctive behaviors were conducted by using the Widström's 9 Stages method.According to the dosage of oxytocin, subjects were divided into a low dose group (2.5 U) of 39 pairs, a medium dose group (≥ 5 U) of 38 pairs, a high dose group (≥ 10 U) of 38 pairs and a control group (no synOT use) of 39 couples. The occurrence time of newborns' instinctive movements and the duration time of each behavior stage for the four groups were also analyzed.The frequency of exclusive breastfeeding within 3 days after birth and the rate of exclusive breastfeeding at 3 months were collected and compared.Results: The intrapartum administration of synthetic oxytocin affects the expression of neonatal instinctive breastfeeding. With increases in drug dose, the effect of breast seeking activity and breast attachment will be more significant, and the effect of oxytocin on sucking and breastfeeding was dose-dependent.Conclusions: Intrapartum exposure to the different doses of synOT could affect the neonatal instinctive behaviors during skin-to-skin contact within two hours after birth to varying degrees, there were also adverse effects on the initiation and continuation of postpartum breastfeeding, with dose-dependent results.
Epidemiology of Human Adenovirus in children hospitalized with Community-acquired Gastroenteritis under the age of five years
Authors: Khan Nazif Ullah , Shamsullah  , Shahidullah  , Shah Aamir Ali , Zaidi Sayed Sohail Zahoor , Chen Zhi
Published: April 2022

Background: Acute gastroenteritis is the major cause of morbidity and mortality among infants and children around the globe. Along with other enteropathogens, human adenoviruses (HadV) are considered a major etiological agent associated with diarrhea in young children. However, information about the epidemiology of adenoviruses in Rawalpindi and Lahore, the two cities of Punjab province, Pakistan is not reported yet.Methods: A total of 384 fecal samples were negative for rotavirus, out of 1082 from a patient with acute gastroenteritis, under the age of five years with symptoms like watery diarrhea, visiting Benazir Bhutto hospital Rawalpindi and Children hospital Lahore were enrolled in this study. Human adenoviruses were tested for primary isolation in the human epithelial HEp-2 cell line. Furthermore, adenovirus antigen detection was carried out by enzyme-linked immunosorbent assay (ELISA), and then all the positive and negative samples were confirmed by nested PCR.Results: After inoculation stool, supernates on HEp-2 cell lines showed a positive cytopathic effect in 65 (16.) patients. Using an enzyme immunosorbent assay HAdV, antigens were detected in 54 (14.06%) samples. However, HAdV hexon coding regions were amplified in 57 (14.80%) fecal samples mostly from patients equal to or under 24 months of age.Conclusion: The findings of this study revealed that adenovirus is the etiological agent of gastroenteritis in the mentioned cities and provides the baseline data about the possible role of adenovirus in causing diarrhea in children. Further large-scale epidemiological surveys are required for a better understanding of disease burden and its clinical impact.