bluuebunny/crossref_metadata_2025 huggingface dataset:
Lung Adenocarcinoma Expression of the Aryl Hydrocarbon Receptor Promotes PD-L1 and Immune Suppression
Authors: Snyder Megan , Lara Brian , Wang Zhongyan , Fimbres Jocelyn , Khan Mohammed Muzamil , Song Gang , Mazzilli Sarah A , Monti Stefano , Sherr David
Published: August 2023

Immunotherapy has shown dramatic results in treating cancer, but only a minority of patients benefit. Therefore, there is an unmet medical need to understand the regulation of immune suppression in tumors. We show that the aryl hydrocarbon receptor (AhR) is a central player in regulating immune checkpoints in a mouse model of lung adenocarcinoma (LUAD). Within the murine malignant cell, AhR regulates expression of several genes important to suppressive immune signaling, including PD-L1. We find similar immune-related regulatory mechanisms in human LUAD cells. Notably, the presence of IFNγ boosts the expression of these AhR-regulated suppressive genes, suggesting a deleterious role for IFNγ in LUAD. Transplantation of mouse AhR-knockout CMT167 (CMT167AhR-KO) LUAD cells leads to partial or complete tumor rejection and protection from wild type (WT) LUAD challenge. CMT167AhR-KO tumors that do form have decreased PD-L1 expression and increased T cell infiltration relative to AhR+ control tumors. To identify specific immune cell subsets involved in AhR-related tumor immunity, we employed an imaging mass cytometry (IMC) platform coupled with single cell RNA sequencing of tumor infiltrating CD45+ immune cells. Understanding the phenotypes and spatial orientation of the immune cells interacting with malignant cells will provide evidence of the key immune populations responsible for anti-tumor immunity and thus help pave the way for future therapies and biomarkers relevant to improving treatments for LUAD patients.

Find the Cause Consortium Gifts
Molecular regulation of CD8 T cell exhaustion in a mouse model of acute lymphocytic leukemia
Authors: Gomez Amber , Green William D , Green Jarred M , Baldwin Albert , Milner Justin
Published: August 2023

Acute lymphocytic leukemia (ALL) is a rapidly progressive form of leukemia more commonly found in children. Individuals nonresponsive to or ineligible for traditional chemotherapy and allogeneic hematopoietic cell transplant turn to alternatives like immunotherapies. While promising, current FDA approved immunotherapies for ALL have varying efficacy rates. CD8 T cell dysfunction or exhaustion is a key contributor to immunotherapy resistance, yet the molecular mechanisms controlling CD8 T cell exhaustion in ALL remain unclear. Here we sought to define those mechanisms in a mouse model of ALL. We utilized a syngeneic B cell acute lymphocytic leukemia mouse model (B-ALL: Arf−/− p185+ BCR-ABL+ pro-B cells) to profile the distribution and molecular features of B-ALL specific CD8 T cells across multiple tissue sites and disease stages. We also compared tumor-specific CD8 T cell responses across B-ALL and solid tumor models to define both conserved and B-ALL specific phenotypes. Our findings indicate that B-ALL specific CD8 T cells share conserved features of exhausted CD8s, but also exhibit exhaustion-features unique to B-ALL. Ongoing experiments seek to define the transcriptional and epigenetic mechanisms guiding B-ALL specific CD8 T cell exhaustion, which may facilitate adoptive cell therapy strategies to improve CD8 T cell function and immunotherapy efficacy.

Supported by a grant from NIH (T32 GM133364)
Simple eigenvalues of cubic vertex-transitive graphs
Authors: Guo Krystal , Mohar Bojan
Published: August 2023

If
${\mathbf v} \in {\mathbb R}^{V(X)}$
is an eigenvector for eigenvalue
$\lambda $
of a graph X and
$\alpha $
is an automorphism of X, then
$\alpha ({\mathbf v})$
is also an eigenvector for
$\lambda $
. Thus, it is rather exceptional for an eigenvalue of a vertex-transitive graph to have multiplicity one. We study cubic vertex-transitive graphs with a nontrivial simple eigenvalue, and discover remarkable connections to arc-transitivity, regular maps, and number theory.
Conservative ideas in pedagogical thinking of phenomenologist Ján Patočka and personalist Ladislav Hanus
Authors: Potočárová Mária
Published: August 2023

In this paper we focus on the reflection of conservative ideas reflected in pedagogical thinking. The conservative trend in the philosophy of education is presented in a selection of two representatives from the environment of the former Czechoslovakia, who lived and were active in the period of totalitarian real socialism. We present the philosopher and phenomenologist Ján Patočka and the personalist and theologian Ladislav Hanus. Both of them are united by the fact that their works are based on the common philosophical direction of phenomenology and existentialism. In addition, both representatives, above all, through their personal life stories, have been committed to humanistic and conservative values, for which they had to endure persecution during the totalitarian period. They tried to pass on their convictions through the formation, upbringing and education of the younger generation. This common purpose also linked them to pedagogy, to the development of philosophical pedagogical thinking. This article will compare the philosophical views of both, as well as the personalistic and anthropological conceptions of society that were rooted in phenomenology as well as in the tradition of Christian humanism. The contribution of the life and work of J. Patočka and L. Hanus remains significant for contemporary pedagogy and philosophy of education. The paper has also attempted to add some of the basic knowledge of philosophy of education needed in the education of future teachers.
O pułapce „skojarzeniowej” w humanistyce (na marginesie uroszczenia S. Gałkowskiego w jego próbie „logicznej” wykładni Znanieckiego)
Authors: Witkowski Lech
Published: August 2023

Autor polemiki we wstępie wskazuje na zjawisko reductio ad absurdum koncepcji Znanieckiego w wykładni adresata jego krytyki. Dalej jest zarysowana ogólna perspektywa sprzeciwu wobec podejścia Stanisława Gałkowskiego. Przedstawiono także krytycyzm i pochwały wobec Znanieckiego ze strony autora polemiki. W tekście wskazuje się na pułapkę czytania epistemicznego jako etyczne nadużycie logiki. Wreszcie, zamiast zakończenia, mówi się o traktowaniu tradycji myśli humanistycznej i uczula na błędy interpretacyjne popełnione przez krytykowanego autora. Główny błąd polega na skojarzeniach czytelnika blokujących mu głębszy dostęp do znaczenia czytanej koncepcji.

On the “Associationist” Trap in Humanities. (Within the Marigin of False Claim by S. Galkowski in His Effort of “Logical” Exegesis of Znaniecki):
In his introduction the author of this polemic indicates the phenomenon of reductio ad absurdum of Znaniecki’s conception in the exegesis of the addressee of this criticism. Next there is an outline sketched concerning the general perspective of disagreement against the approach by S. Gałkowski. There is also outlined criticism and appraisal towards Znaniecki by the author of this polemics. The text illustrates the trap of an epistemic reading as an ethical abuse of logics. Finally instead of a conclusion one is discussing the ways of treatement of the tradition of humanistic reflection and it warns against interpretative errors committed by the criticised author. The basic error is perceived as the result of domination of application of harmful associations of the leader blocking the way to deeper sense of the conception.
MONITORING OF THE RIVERS OF THE BLACK SEA BASIN FLOWING THROUGH THE SETTLEMENTS OF THE ADJARA REGION
Authors: Darchidze Guram
Published: August 2023

Guram Darchidze

Email:darchidz1995@gmail.com

Ph.D. student, Georgian Technical University

Tbilisi, Georgia

https://orcid.org/0000-0002-7597-856X

Abstract. The problem of water pollution is becoming more and more urgent for the world. Despite the implemented measures, improvement of wastewater treatment methods, the issue remains relevant. One of the most common is biological pollution, directly related to the entry of pathogenic microorganisms, bacteria, viruses and protozoa into water.

The effects of water pollutants on specific waters vary and may not always be fully appreciated. However, we know these pollutants harm drinking water supplies, recreation, fisheries, and wildlife. That is why it is necessary to find the source of biological water pollution, to study its age and lethality, to develop an effective method of pollution elimination.

The topic "Monitoring of the rivers of the Black Sea basin flowing through the settlements of the Adjara region" presents the areas of human activity of large and small rivers in the Adjara region and the research and evaluation of the pollution caused by them.

For the process of development of the topic, an initial study was carried out on more than 300 large and small rivers flowing in Adjara territory. They were studied and evaluated in terms of biological contamination.

16 rivers were selected, on which a bacteriological study was carried out to determine the presence of fecal waste, discharge, turbidity and E-Coli (in field conditions) were determined on other sources.

In the report, I have presented the following works:

Evaluation of rivers at the stage of the primary study, assessment of type, discharge, turbidity, E.Coli and other types of anthropogenic pollution. 2. Laboratory research conducted to determine the level of contamination with fecal waste; 3. After determining the level of pollution, the search for centers of pollution was carried out; 4. After finding the foci, evaluating these foci and determining the probable age of the future pollution capacity; 5. After the evaluation of the pollution centers, recommendations for the elimination of pollution were developed, both informational, constructive, and biological/chemical. 6. According to the data obtained in the research, a histogram was constructed and the data were grouped according to the optimal number of intervals; 7. According to the data obtained in the research, a graph of dependence on the debit of pollution with fecal waste was constructed.

Conclusions are drawn, including the implementation of work to eliminate the problem of the existing situation.
IMPORTANCE OF FINANCIAL SERVICES’ TRANSPARENCY AND THE FINANCIAL EDUCATION FOR THE PROTECTION OF CONSUMER RIGHTS IN GEORGIA
Authors: Gavtadze George , Iphshiradze Aza
Published: August 2023

George Gavtadze

Email:george.gavtadze@atsu.edu.ge

Professor, Akaki Tsereteli State University

Kutaisi, Georgia

https://orcid.org/0000-0001-6080-0163

Aza Iphshiradze

Email:a.iphshirdze@unik.edu.ge

Professor, Kutaisi University

Kutaisi, Georgia

https://orcid.org/0009-0005-8373-3043

 

Abstract. The issues of financial services’ transparency, consumer rights protection, financial education are relevant and the feasibility of their study is determined by the features of social-economic development. To overcome the problem, to some extent, it is possible to create and develop regulatory schemes for the protection of consumer rights. As research shows, priorities and practical implementation of consumer rights protection differ from country to country. The regulation is mainly aimed at providing complete information about the product to the consumer. However, in addition to imperative regulatory norms, in developed countries, the existence of self-regulation mechanisms, such as codes of conduct, is also of great importance.

Despite the adoption of a number of laws and legislative acts, creation of regulatory documents, etc., in terms of further improvement of consumer rights protection, at the modern stage, the greatest emphasis is still placed on financial education and raising consumer awareness. Consumer rights protection and financial education are two sides of the same coin and serve the same purpose.

For more than a decade, many countries have been implementing projects aimed at raising the level of financial education, which, for the most part, is manifested in the development of a national strategy for financial education. It should be noted that the need to develop a national strategy is often coupled with consumer financial protection and financial inclusion measures. At the same time, it should take into account and be adapted to the needs and shortcomings of a specific country.

As a result of the analysis of the current situation, we can conclude that the improvement of financial services, the protection of consumer rights and their financial education can bring significant benefits not only to individuals or groups of people, but also to the country as a whole (both developed and developing).
Comparative analysis of HPLC profiles and antioxidant activity of Artemisia alba Turra from two habitats in Serbia
Authors:   University of Niš, Faculty of Science and Mathematics, Department of Chemistry, Ickovski Jovana D. , Mitić Milan N. ,   University of Niš, Faculty of Science and Mathematics, Department of Chemistry, Stojković Milan B. ,   University of Niš, Faculty of Science and Mathematics, Department of Chemistry, Stojanović Gordana S. ,   University of Niš, Faculty of Science and Mathematics, Department of Chemistry
Published: August 2023

Artemisia alba Turra was collected at the blooming stage on two different locations in Serbia, Mojinci and Rosomač. Antioxidant activity and HPLC profiles of their methanolic extracts were determined and compared. Flavonoid compounds found in both samples were rutin, apigenin glucoside, quercetin, luteolin, kaempferol and apigenin, while detected phenolic acids were chlorogenic acid, p-coumaric acid, cynarine and rosmarinic acid. The only observed qualitative difference was related to the presence of vanillic acid. Extract of A. alba from Rosomač was richer in phenolic compounds and flavonoids than A. alba from Mojinci. The extract of A. alba from Rosomač also possessed higher antioxidant capacity than A. alba from Mojinci, which was especially noticed in the 2,2-diphenyl-1-picrylhydrazyl assay. Only the results for the ferric ion reducing antioxidant power assay were higher for extract of A. alba from Mojinci, than for the extract of A. alba from Rosomač.
History of the Periodic System of the Elements
Authors:   University of Niš, Faculty of Science and Mathematics, Department of Chemistry, Kostić Danijela , Krstić Nenad ,   University of Niš, Faculty of Science and Mathematics, Department of Chemistry, Blagojević Marina ,   University of Niš, Faculty of Science and Mathematics, Department of Chemistry
Published: August 2023

There were several attempts to classify known elements before Mendeleev. Numerous scientists, such as John Newlands, Alexandre-Emile Beguyer de Chancourtois and Julius Lothar Mayer, have contributed to the discovery of the periodic table. Mendeleev was not the first to try to arrange the elements according to their properties, but he was the first to recognize and leave empty positions for the elements to be discovered. Many of his predictions came true and time confirmed the periodic law and the accuracy of the periodic table of elements.
Keselarasan Iringan dan Gerak Tari Tapel Telu Sanggar Gedeng Kedaton Lendang Nangka Lombok Timur
Authors: Markarma Muh. Ridwan , Zaiful Zaiful , Huliazati Eka
Published: August 2023

Tujuan penelitian ini adalah untuk mengetahui keselarasan  iringan dan gerak tari kreasi Tapel Telu di Sanggar Gedeng Kedaton Lendang Nangka Kecamatan Masbagik. Dengan menggunakan teori keselarasan, iringan musik, dan gerak tari. Metode yang digunakan pada penelitian ini menggunakan metode kualitatif dengan pendekatan etnografiskarena mengkaji dalam bentuk budaya yaitu kesenian gamelan, tari, dan pesan moral dalam tari adalah pesan budaya. Karena memaparkan tentang keselarasan iringan dan gerak tari kreasi Tapel Telu di Sanggar Gedeng Kedaton Lendang Nangka Kecamatan Masbagik. Teknik pengumpulan data yaitu menggunakan observasi, wawancara dan pengumpulan data dengan dokumentasi. Hasil penelitian menunjukkan bahwa sebagian besar iringan dan gerak tari kreasi Tapel Telu ini selaras baik dari makna atau dari ketukan iringan dan gerakan, namun ada beberapa diantara aspek gerak dan iringan tidak selarasyang mengharuskan tarian ini digubah kembali agar terdapat kesesuain antara iringan dan gerak.
INTERCULTURAL COMMUNICATION ON TRADING TRANSACTION AT PRINGGARATA TRADITIONAL MARKET
Authors: Aristiawan Danul
Published: August 2023

Interactions gave various kinds of relationships, one of them was on traders relationship. Buyer and seller was relationship that has been effects in human life. Humans as social beings will always have relationships with each other in order to fulfill their life needs. This relationship will occur if it is based on communication. In this regard, communication plays an important role in human life. But the importance of communication will be felt if humans know what communication actually is and how the delivery process was carried out, so that it takes place effectively. In essence, communication is a process of expression between humans, what expressed, thoughts or feelings to others by using language as a channel. In buyer and seller interaction process, the ability to communicate (communicative competence) which was based on the speaker's cultural system, it can support the success of work in the informal sector. As a means of communication and self-expression, language can affect the thoughts and feelings of other humans, so that with language, a person is able to make other people take responsive actions according to the messages exchanged. Broadly speaking, communication is the process of conveying thoughts, feelings, or messages from one person (communicator) to another (communicant). With the medium of language, a communicator is able to influence the communicant and the message conveyed can be understood according to the meanings contained therein. Communication will be successful if the thoughts conveyed by the seller and the buyer can be understood precisely and equally by both parties. Thus, sellers and buyers are the determinants of communication practices and understanding of the messages communicated.
IMPLICATURE ANALYSIS ON ONLINE LECTURE COURSES OF ENGLISH EDUCATION STUDY PROGRAM
Authors: Fitria Nadhea Intan , Setyawan Agustinus Hary
Published: August 2023

This research aims to reveal the types and implied meaning of implicature found in an online lecture courses of English education study program at one of the university in Yogyakarta. In this research using descriptive qualitative research methods by a theory from Grice (1975). The data findings consist of the three main implicatures consist of generalized conversational implicature with 14.3%, particularized conversational implicature with 8.6% and conventional implicature with 8.6%. Then, the four implicature functions are reach the intended meaning with 20%, deliver an entertainment as humor with 8.6%, boosting the power's of person's message with 14.3%, and specific information needs to be added with 25.6%. By adding up the total between main implicature and implicature functions, it turns out to be 100%. The three main implicature most widely used is generalized conversational implicature. As well as the most frequently used in the implicature function is, specific information needs to be added.
Pemberdayaan Posyandu Lansia Melalui Pelatihan Pembuatan Kwetiau Labu Kuning Sebagai Alternatif Makanan Tambahan Bergizi
Authors: Juwitaningtyas Titisari , Zahrotun Lisna , Soyusiawaty Dewi , Purwaningsih Eni
Published: August 2023

Lansia (elderly) is a group of people aged 60 years and over. In an effort to maintain the quality of life of the elderly, the government of the Republic of Indonesia formed an organization called Posyandu Lansia. Posyandu Lansia is a forum for the elderly that is useful for health services, both promotive and preventive efforts. One of the elderly posyandu in Bantul Regency, Yogyakarta Special Region which is active in its activities is Posyandu Lansia Wredho Utomo. There are 7 posyandu members. In the community service activities carried out, the program regarding healthy food is chosen as the main program. The healthy food program chosen was a training program for making independent food using processed kwetiau modified with pumpkin or pumpkin. Kwetiau is a food diversification based on processing from rice flour and tapioca flour. To increase the nutritional content, a pumpkin is added. Limited access due to the COVID-19 pandemic has resulted in this training being delivered in the form of a video which is then practiced independently by participants in their respective homes. According to the assessment of the participants, all participants stated that the videos they made were considered interesting and effective and most of them said the videos that were delivered made the participants enthusiastic.
Enhancing Creativity: The Role of Affective Commitment and Knowledge Sharing
Authors: Noerchoidah  , Harjanti Dhyah , Dwiarta I Made , Suprapto Widjojo
Published: August 2023

As higher education institutions were facing strong competition to attract new coming students, the contributions of lecturers were acknowledged as one of the driving resources of the university’s competitive advantage. Besides teaching, all lecturers were required to conduct research and social services. While fulfilling these tasks, some lecturers focused on one aspect only and neglect the others. This situation created a disparity in lecturers’ creative mindsets, as they keep on doing similar tasks repeatedly. Creativity developed by the lecturers could become the competitive advantage of their university. The objective of this study was to examine how lecturers’ creativity is constructed. Two influencing factors, which are affective commitment and knowledge sharing, were tested to see their influences on creativity. The data were collected from 170 randomly selected lecturers of private universities who obtained an “A” accreditation. Since this was quantitative research, the collected data were processed with the Partial Least Square technique. The results showed that lecturers’ creativity was significantly affected by knowledge sharing as well as affective commitment. However, knowledge sharing did not mediate the relationship between affective commitment and creativity.
Does Transformational Leadership and Flexible Working Arrangements Affect Journalist Performance? The Mediating Role of Job Satisfaction
Authors: Rahman Syaiful , Wijayati Dewie Tri , Kistyanto Anang
Published: August 2023

The purpose of this study was to evaluate the effect of transformational leadership and flexible working arrangements on the performance of journalists through job satisfaction. Data was collected from journalists who are members of the Indonesian Journalists Association of East Java Province (PWI East Java) through a questionnaire survey that was distributed. A total of 100 completed questionnaires were received. The hypothesis was tested using the Structural Equation Modeling-Partial Least Squares (SEM-PLS) approach supported by the Smart-PLS 3 computer software program. The results of the study show that transformational leadership, flexible work arrangements, and job satisfaction have a significant positive correlation with journalist performance. It was also found that job satisfaction mediates the relationship between flexible work arrangements and journalist performance. However, job satisfaction does not mediate the relationship between transformational leadership and journalist performance. This study proposes that companies need to ensure that leaders at all levels have strong transformational leadership qualities and create a work environment that can increase employee satisfaction. Companies must understand the factors that can increase job satisfaction, such as providing constructive feedback, work flexibility, and a healthy work-life balance. By increasing job satisfaction, employees will feel more satisfied with their jobs, which will ultimately have a positive impact on their performance. This kind of research has not been completed or even not discussed in academic research. Therefore, this problem needs to be included in management science.
Perilaku Koruptif Dalam Praktik Manajemen Laba: Sebuah Tinjauan Perspektif “Ati Mapaccing” dalam Falsafah Bugis
Authors: Jumardi Jumardi , Marina Palimbong Stefani
Published: August 2023

Earnings management emerged in the field of financial accounting as a consequence of the efforts of managers or financial statement preparers to regulate the earnings cycle for personal and/or corporate interests or benefits. This study aims to gain an understanding of the opinions and behavior of informants including management accountants, public accountants, investment advisors, tax examiners and Bugis cultural observers on earnings management practices carried out by managers and viewed from the perspective of Classical Bugis philosophy. This type of research is a qualitative research with a hermeneutic approach, or more specifically an interpretive approach. Sources of data in this study are primary data and secondary data. Data collection techniques used in this research are interviews, documentation, literature study, internet searching. The data analysis technique was carried out through four paths, namely data reduction, data presentation, data validity test and conclusion drawing.The results show that in the perspective of management accountants and public accountants, earnings management practices cannot be viewed as earnings manipulation as long as these practices are carried out within the framework of accounting standards. They also argue that earnings management is not said to be corrupt behavior, unless the practice is not carried out in accordance with accounting standards. While the views of investment advisors and tax inspectors, the practice of accounting standards carried out with any pattern and strategy is a reflection of corrupt behavior because of a corrupted mind. They argue that earnings management practices are always carried out systematically based on certain motivations and interests. Earnings management is a practice that is of no value to the company's stakeholders so this practice should be avoided. Viewed from the perspective of ati mapping that earnings management can be seen from the good or bad intentions of a manager in carrying out his practice, motivation or interests that are detrimental to other parties, it can be said that the practice of earnings management is an act of fraud that can be categorized as a corrupted line of thought.
Results of the first GSEV survey in Germany
Authors: Menck Kerstin
Published: August 2023

Research on extracellular vesicles is on the rise, world-wide and also in Germany. This report summarizes the main findings of the first online survey that was conducted by the German Society for Extracellular Vesicles (GSEV). The eleven questions were aimed at identifying research topics of interest and ideas for future developments of GSEV.
Hanseníase
Authors: Baptista Ida Maria Foschiani Dias
Published: August 2023

A hanseníase está inserida no âmbito das doenças tropicais negligenciadas (DTNs) e, embora seja uma doença antiga, ainda hoje está relacionada às baixas condições socioeconômicas das populações. Como muitas outras en-fermidades, ela afeta os mais vulneráveis e marginalizados em todo o mundo.Essas desigualdades são frequentemente impulsionadas por estruturas po-líticas, sociais e econômicas que flertam as ações de curtíssimo prazo que, ao contrário de solucioná-las, são responsáveis pela má qualidade dos sistemas de saúde nos países mais pobres.
Leprosy in 3-year-old twin children in Mato Grosso, Brazil
Authors: Lopes José Cabral , De Osti Pietra Andrade , Cavalcante Leticia Rossetto da Silva , Gomes Ciro Martins , Damazo Amílcar Sabino
Published: August 2023

Introduction: Mycobacterium leprae is a microorganism that cause leprosy; it has a long, silent, and consumptive evolution. Case Report: twin children with three years old were contactants of a leprosy patient in the family. The two patients have well-defined and irregular skin lesions. Also, they have the BCG-vaccine scar. They were confirmed positive to Mycobacterium by histopathological analysis. Discussion: Especially under five years old, diagnoses are rare and difficult because they simulate other diseases, especially rheumatology. These diagnoses are epidemiological alarms for endemic areas. It shows the importance of symptoms in children and the screening in patients' contact already identified.
Magnitude dos episódios reacionais na hanseníase em serviço ambulatorial especializado
Authors: Chaves André Felipe de Castro Pereira , Araújo Olívia Dias de , Sousa Ellen Cristina da Costa Leite , Cardoso Jonas Alves , Rodrigues Érica de Alencar , Moura Edmércia Holanda
Published: August 2023

O objetivo do estudo é caracterizar os episódios reacionais segundo os dados sociodemográficos, clínicos e epidemiológicos de pacientes com hanseníase em um município hiperendêmico do estado do Piauí, Brasil, no período de 2013 a 2017. Para tanto, um estudo descritivo, transversal e retrospectivo utilizou-se os casos de hanseníase, notificados no Sistema de Informação de Agravos de Notificação (SINAN), juntamente com a ficha de dispensação de medicamentos do local em estudo. Foram realizadas análise univariada, por meio de estatística descritiva simples, e análise bivariada, utilizando o Qui-quadrado de Pearson para associar as variáveis quantitativas com a variável resposta do estudo, que é o momento da reação hansênica. A significância estatística foi fixada em p<0,05. Observou-se que a maioria dos episódios reacionais ocorreram durante o tratamento para hanseníase. Homens, pardos, pessoas com ensino fundamental completo ou incompleto, pedreiros, moradores da zona urbana, indivíduos dimorfos, multibacilares e com presença de grau 0 de incapacidade física, predominaram no aparecimento de reação. A reação que prevaleceu foi a do tipo 1, seguida pelo tipo 2, e em última, a reação mista. Diante disso, compreende-se que as vulnerabilidades individuais, sociais e econômicas impactam diretamente no desenvolvimento de reação hansênica.
Características sociodemográficas e epidemiológicas relacionadas ao grau de incapacidade física em hanseníase no estado da Paraíba, Brasil
Authors: Véras Gerlane Cristinne Bertino , Silva Luiz Henrique da , Sarmento Wagner Maciel , Moraes Ronei Marcos de , Oliveira Simone Helena dos Santos , Soares Maria Júlia Guimarães Oliveira
Published: August 2023

Objetivou-se analisar a associação entre características sociodemográficas e clínicas com o desenvolvimento dos graus de incapacidades físicas 1 ou 2 em pessoas com diagnóstico de hanseníase na Paraíba, Brasil. Estudo ecológico, de base populacional, que teve como unidades de análises os 223 municípios do estado. Os dados foram coletados no Núcleo de Doenças Crônicas e Negligenciadas/Hanseníase, pertencente à Gerência Executiva de Vigilância em Saúde da Secretaria de Saúde do estado da Paraíba em junho de 2021, após extração do Sistema de Informação Nacional de Agravos de Notificação. O banco de dados reuniu 2.468 casos novos de hanseníase registrados no período de 2016 a 2020. A chance de uma pessoa diagnosticada com hanseníase desenvolver a incapacidade física 1 ou 2 é maior nas pessoas de sexo masculino, com 15 anos ou mais, estudo formal menor ou igual a nove anos, classificação operacional multibacilar, com mais de cinco lesões e mais de um nervo afetado, além de baciloscopia positiva. Políticas de educação em saúde são fortemente recomendadas no intuito de melhorar o conhecimento dos profissionais e da comunidade. Abordagens sobre a hanseníase, diagnóstico precoce, busca ativa, vigilância e acompanhamento dos casos e de seus contatos, além das incapacidades físicas, em especial para pessoas de maior vulnerabilidade a desenvolvê-las, são fundamentais.
ANALYZING USER PASSWORDS WORLDWIDE IN TERMS OF CYBER THREATS
Authors: GÜRFİDAN Remzi
Published: August 2023

Analysing user passwords used around the world is a very broad topic and involves a variety of factors. Password analysis is usually based on detailed studies by security experts, cyber security researchers and encryption experts. Weak passwords, repeated passwords, simple patterns, short passwords, personal information are critical contents that create vulnerabilities and are ignored by users. Attackers or attack tools working for password interception can easily intercept passwords that contain security measures below a certain level, that is, passwords that are not complex. The purpose of this study is to analyse global password usage, to increase users' awareness about password security and to encourage users to use stronger passwords. Small program snippets and new tools have been coded to achieve this goal. In future studies, it is aimed to improve the current application by automating the control of the distance of the texts from each other as a new password suggestion method and hybridising machine learning methods.
Computational statistics for time-series forecasts via SAS/ETS 9.4 drop-down menu
Authors: Rahardja Dewi
Published: August 2023

In this paper, using the Statistical Time Series (TS) methodologies reviewed in the literature, we present a step-by-step computational statistics procedure to execute TS forecasts computing via a point-and-clicks (semi-automatic) option of SAS (Statistical Analysis Software). Such point-and-clicks pathway of computing is via the SAS Econometrics Time Series 9.4 (SAS-ETS) drop-down menu. This paper will be very beneficial for forecasters in multiple areas of applications (e.g., business, epidemiology, sociology, etc.) without much expertise in the Statistical TS methodologies.
Evaluation of Climate Change Effects on Rain Rate Distribution in Malaysia using Hydro-Estimator for 5G and Microwave Links
Authors: Basarudin Hafiz , Mohd Yunus Noor Hidayah , Ramli Aizat Faiz , Mansor Zuhanis , Sali Aduwati , Gan Hong Seng , Abu Mohd Azlan
Published: August 2023

Wireless transmissions at more than 10GHz can experience signal fading caused by the presence of hydrometeor particles in the atmosphere. Among these hydrometeors, rain is the largest contributor to the fading mechanism. Rain fade can be predicted or calculated using rain rate measurements. With climate change affecting the world due to the rise of carbon dioxide in the air, it is expected to affect the distribution of rainfall, which ultimately affects rain fade. This paper investigates the effects of climate change on rain rate distribution in Malaysia. Ten years of Hydro-Estimator data containing rainfall rates in Peninsular Malaysia and the Sabah and Sarawak region from 2011 to 2020 were collected and analyzed. Using the linear regression method, a small increment of rain rate distribution at 0.01% annual probability was detected for all regions, indicating a climate change effect on the rain rate distribution. For Peninsular Malaysia, the rate was 0.2356mm/hr per year while for the Sabah and Sarawak region, it was 0.4046mm/hr per year. An increase in the rain rate would increase the rain fade, causing signal losses and distortions in high-frequency wireless communication signals. The evaluation of climate change effects on the rain rate and rain fade distributions can help in developing a long-term prediction of the signal performance in 5G systems and high-frequency radio link frequencies due to hydrometeors.
Dynamic Soil-Structure Interaction of Multi-Story Buildings using the Finite Element Method and Minimax Probability Machine Regression
Authors: Kar Saurav Shekhar , Athawale Anupama Arunkumar , Bhushan Mani , Roy Lal Bahadur
Published: August 2023

Soil-Structure Interaction (SSI) issues are some of the most critical problems encountered in the design of structures prone to earthquake shaking. The damage caused by an earthquake mainly depends on the interaction between soil and structure. In this study, the effect of dynamic SSI on a multi-story building is examined using two methods, Finite Element Method (FEM) and Minimax Probability Machine Regression (MPMR). The MPMR was used to develop a model based on the input and output database generated from the FEM model. The performance comparison of these two models shows a good correlation. The MPMR model significantly reduced the computational time and can thus be utilized as a substitute for determining the response quantities.
Properties of Recycled Concrete utilizing Waste Rubber
Authors: Badawi Moataz , Ahmed Ayman G. , Eldamaty Tarek A. , Helal Medhat M.
Published: August 2023

Globally, billions of tires are being disposed of, representing a natural danger. Until now, a little part of that waste is reused, and most tires are simply accumulated. The present paper studies the durability phenomena of recycled concrete with partial substitution of fine aggregate by waste rubber tires. Silica fume, fly ash, and Cement Kiln Dust (CKD) were utilized as substitutions for the binding material. The overall substitution material reached about 30% of the cement content. The long-term behavior was surveyed by methods for water retention, chloride ions penetrability at 28 and 90 days, and protection from aggressive media (sulfate) at 1, 7, 14, and 28 days. Likewise, the compressive strength of concrete samples at 7, 14, 28, and 90 days was measured. The presence of cementitious framework, CKD, silica fume, and fly ash limit the utilization of waste rubber. Substitution percentages of up to 10% rubber fraction and 30% paste framework accomplish a satisfying strength level (35 MPa). These blends also exhibit higher protection from sulphuric corrosive assault than the reference blend.
The Effect of Cracks on the Free Vibration of a Plate with Parabolic Thickness
Authors: Le Vinh An , Nguyen Xuan Tung
Published: August 2023

This paper uses first-order shear deformation theory and the finite element method to analyze the vibrations of rectangular plates with one or more cracks. The study investigated the influence of cracks (length, angle of inclination), the number of cracks, and the ratio of plate thickness to the natural vibration frequency of the plate, using phase field simulation. Plate thickness varies nonlinearly with the parabolic function. The results of the proposed method were compared with reputable studies to verify its reliability. In addition, some pictures of the characteristic vibration patterns of the plate with varying thickness are presented when cracks appear.
Damage Identification of Suspension Footbridge Structures using New Hunting-based Algorithms
Authors: Long Nguyen Ngoc , Quyet Nguyen Huu , Tung Nguyen Xuan , Thanh Bui Tien , Hoa Tran Ngoc
Published: August 2023

Metaheuristic algorithms have been applied to tackle challenging optimization problems in various domains, such as health, education, manufacturing, and biology. In particular, the field of Structural Health Monitoring (SHM) has received significant interest, particularly in the area of damage identification in structures. Popular optimization algorithms such as Genetic Algorithm (GA), Particle Swarm Optimization (PSO), Cuckoo Search (CS), Teaching Learning Based Optimization (TLBO), Artificial Hummingbird Algorithm (AHA), Moth Flame Optimizer (MFO), among others, have been employed to address this problem. However, notwithstanding the wide recognition of the current algorithms, their constraints are commonly acknowledged. Hence, this article advocates for the adoption of innovative hunting-inspired algorithms, namely the Ant Lion Optimizer (ALO), African Vulture Optimization Algorithm (AVOA), Grey Wolf Optimizer (GWO), Marine Predator Algorithm (MPA), and Whale Optimization Algorithm (WOA), which emulate the behaviors of wildlife species, to discern the areas and magnitudes of deterioration in a suspension footbridge. Moreover, in order to reduce computational time, only natural frequencies are applied as objective functions. The obtained results indicate that all the utilized algorithms can accurately detect the damages in the considered structure.
Indicative Factors for SACCOs Failure in Tanzania
Authors: Magashi Cosmas , Sam Anael , Agbinya John , Mbelwa Jimmy
Published: August 2023

SACCOs are viewed as a feasible opportunity toward financial inclusion in an economy where most of the citizens are poor, as they are very essential for the socio-economic development of members, the community, and the world at large. However, SACCOs sometimes do not realize the expected socio-economic potential, especially when they fail. This study aimed to comprehensively assess financial and non-financial factors, at institutional and personal levels, that contribute to the failure of SACCOS in Tanzania. The data were collected using a questionnaire on 5,000 members of SACCOs, obtained using stratified random sampling. Data collected were analyzed using descriptive statistics and binary logistic regression. The findings showed that both financial and non-financial factors, at personal and institutional levels, had a statistically significant and positive relationship with the failure of SACCOs. Therefore, the performance of SACCOs and other Microfinance Financial Institutions (MFIs) should be addressed from a comprehensive view of both financial and non-financial factors, at personal or institutional levels. In other words, the failure of MFIs should be addressed from a holistic point of view.
A Machine Learning–Based Approach for Fault Detection in Power Systems
Authors: Ilius Pathan , Almuhaini Mohammad , Javaid Muhammad , Abido Mohammad
Published: August 2023

Machine learning techniques are becoming popular for monitoring the health and faults of different components in power systems, including transformers, generators, and induction motors. Normally, fault monitoring is performed based on predetermined healthy and faulty data from the corresponding system. The main objective of this study was to recognize the start of a system fault using a Support Vector Machine (SVM) approach. This technique was applied to detect power system instability before entering an unstable condition. Bus voltages, generator angles, and corresponding times before and after faults were used as training data for the SVM to detect abnormal conditions in a system. Therefore, a trained SVM would be able to determine the fault status after providing similar test data once a disturbance has been resolved.
An Assessment of Testing and Conditiong Protocol to Evaluate Asphalt Mixtures
Authors: Bazuhair Rabeea W. , Alqahtani Majed A.
Published: August 2023

Asphalt mixtures frequently contain a wide variety of components that may interact. When put into service, they can be damaged due to several factors such as traffic, loading, and environmental impact. Thus, it is necessary to predict or simulate the asphalt mixtures’ damage and performance in service utilizing laboratory conditioning protocols and tests. This paper investigates the property measurements themselves and how a mixture test can simultaneously assess oxidation and moisture damage. In this study, three asphalt mixtures are used with different mixture tests such as Indirect Tensile Tension (IDT), Cantabro Mass Loss (CML), and Hamburg Loaded Wheel Tracking (HLWT). Unaged (control) and two laboratory conditions were utilized to simulate the performance of the mixture in service. The result showed that the laboratory conditioning of the combined effects of oxidation and moisture simulates better the asphalt damages in service than laboratory single environment effect conditioning. The CML test is recommended for the evaluation and capture of these combined damage effects.
Diagnosis of Two-Phase Oil/Gas Flow in a Closed Pipe using an 8-Electrode ECT System
Authors: Ghaly Sidi Mohamed Ahmed , Shalaby Mohamed , Khan Mohammad Obaidullah , Alsnaie Khalid , Mohammed Asad Ali , Baloshi Faisal , Imad Abdelmajeed , Oraiqat Majdi Taha
Published: August 2023

Electrical tomography techniques have been developed to monitor the internal behavior of industrial processes. Electrical capacitance gives the best benefits over other tomography modalities, as it has no radiation, is non-intrusive, and has a low cost. This study investigated the diagnosis of two-phase oil/gas flow in a closed pipe, using an image data capture system for an 8 external electrode Electrical Capacitance Tomography (ECT) sensor. The system had a high-resolution ratio, a small measurement error, and was able to remove the effects of stray capacitance. Experimental measurements were carried out on two different materials that filled the space inside the pipe in different proportions to determine the sensitivity and accuracy of the measurement. The results showed that the system had fast image data capture time, high accuracy, a very small resolution ratio, and a good signal-to-noise ratio and quality factor.
Combining FUCA, CURLI, and Weighting Methods in the Decision-Making of Selecting Technical Products
Authors: Nguyen Anh-Tu
Published: August 2023

Determining the optimal one from the available alternatives is useful in numerous aspects of life. The process of selecting technical products from an available catalog also follows this pattern. This study was carried out to select the best from two types of technical products, the ones that serve in daily life at home, and products that are used in the agriculture field. Air conditioners and washing machines are considered indispensable items in every household. These two types of products directly affect human lives and also indirectly influence labor productivity. Unmanned Aerial Vehicles (UAVs) are used in numerous tasks in the agriculture field, such as inspecting irrigation systems, checking for factors that can harm agricultural products, etc. However, making the decision to buy one of those three types of products may become complicated. This research was conducted to select the best alternative for each of those products. The different types of air conditioners, washing machines, and drones considered in this study were 9, 8, and 7, respectively. Two methods, i.e. RS (Rank Sum) and PIPRECIA (PIvot Pairwise RElative Criteria Importance Assessment) were used to determine the weights for the criteria of each product category. The FUCA (Faire Un Choix Adéquat) method was used in combination with the two weighting methods mentioned above to rank the alternatives of each product category. The CURLI (Collaborative Unbiased Rank List Integration) method was used to complete this task. So, for each product category, there will be three different ranking results. An interesting thing has been achieved is that for each product category, these different ranking results gave the same best solution.
An Efficient Multi-modal Facial Gesture-based Ensemble Classification and Reaction to Sound Framework for Large Video Sequences
Authors: Chopparapu SaiTeja , Seventline Joseph Beatrice
Published: August 2023

Machine learning-based feature extraction and classification models play a vital role in evaluating and detecting patterns in multivariate facial expressions. Most conventional feature extraction and multi-modal pattern detection models are independent of filters for multi-class classification problems. In traditional multi-modal facial feature extraction models, it is difficult to detect the dependent correlated feature sets and use ensemble classification processes. This study used advanced feature filtering, feature extraction measures, and ensemble multi-class expression prediction to optimize the efficiency of feature classification. A filter-based multi-feature ranking-based voting framework was implemented on different multiple-based classifiers. Experimental results were evaluated on different multi-modal facial features for the automatic emotions listener using a speech synthesis library. The evaluation results showed that the proposed model had better feature classification, feature selection, prediction, and runtime than traditional approaches on heterogeneous facial databases.