bluuebunny/crossref_metadata_2025 huggingface dataset:
Measuring the financial stresses of childhood cancer and survivorship.
Authors: Dahlman George , Gallagher Kathleen
Published: September 2018

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G. Dahlman (Children’s Cause for Cancer Advocacy) K. Gallagher (Patient Advocate Foundation) Background: Families battling childhood cancer can face extraordinary financial challenges in access to care. Insurance barriers, coverage limitations and denials, high copays and extraordinary out-of-pocket costs threaten families’ ability to ensure supports necessary for successful treatment. Methods: From April 18, 2017 to May 31, 2017, CCCAA and the Patient Advocate Foundation (PAF) conducted a survey of pediatric cancer patients, caregivers and survivors through an online survey tool. Questions identified demographic and geographic attributes, type of insurance coverage, incidence and reason for insurance denials, degree and source of financial stress, out-of-pocket costs, and survivorship measurements. The survey was sent to unbiased cohort of patients and students from CCCA and PAF. Results: A total of 343 respondents completed the online survey: 143 or 42% were parents or caregivers. Another 143 or 42% were childhood cancer survivors. Among caregivers, 47 or 33% reported insurance denials for treatment, and 63 or 44% reported some level of financial hardship. Among the 44% of respondents reporting financial hardships, 25 or 39% had annual out-of-pocket costs exceeding $5,000. Beyond medical expenses, respondents identified employment and transportation costs, with 87% reporting compromised work schedules and over half reporting trouble getting their child to and from appointments. For survivors, 38 or 27% reported not receiving follow-up care at a late effects clinic, with 34 or 24% reporting that their cancer care impacted their ability to pursue higher education and 43 or 30% reporting that the cost of their medical care impacted their career course or job choice. Conclusions: This joint CCCA/PAF survey identified significant financial challenges, both medical and non-medical, for patients, caregivers and survivors of childhood cancer. This survey along with other data sources suggest that current data and research are insufficient to guide solutions to the care barriers that parents and survivors report.
“L'Aimable Visir”
Authors: Cascavilla Giuseppe Pio
Published: September 2018

This article focuses on the experience of Pierre David, Napoleonic consul in Bosnia from 1807 to 1814, under Hüsrev Mehemed Pasha's tenure as governor of the province (1806–8). It relies on the diplomatic correspondence between David and the Ministry of Foreign Affairs. The goal is to highlight the French interests in the area and their modification after the Treaty of Tilsit; the figure of Hüsrev Mehemed Pasha; the relationship of the locals with the Ottoman authority and the Consul; and the local effects of the revolution that overthrew the reformer sultan Selim III. The article reveals the ineffectiveness of communication from the highest to the lowest levels of French diplomacy in the Levant. It also demonstrates the complex Ottoman center-periphery dynamics during one of the empire's most critical moments.

Cet article se focalise sur l'expérience de Pierre David, consul napoléonien en Bosnie de 1807 à 1814, pendant le mandat de Hüsrev Mehemed Pacha comme gouverneur de la province (1806–8). Par le biais de la correspondance diplomatique entre David et le ministère des Affaires étrangères, nous mettons en évidence les intérêts de la France dans la région balkanique et leur modification après le Traité de Tilsit, ainsi que la figure de Hüsrev Mehemed Pacha ; les relations entre la population locale, les autorités centrales ottomanes et le consul ; et, finalement, les effets locaux de la révolution qui a renversé le sultan réformateur Selim III. Nos résultats montrent un manque de communication entre les différents niveaux de la diplomatie française dans le Levant et une difficulté dans la redéfinition des priorités à l'échelle locale. L'article démontre aussi la complexité des dynamiques centre-périphérie pendant l'un des moments les plus difficiles de l'empire ottoman.
“The Christmas Tree of the Alsatians and Lorrainers”
Authors: Foley Susan
Published: September 2018

This article underlines the significance of emotions in shaping political culture by analyzing a largely forgotten spectacle, the “Christmas Tree of the Alsatians and Lorrainers.” Held annually in Paris from 1872 until 1918, the event aided children whose families had fled Alsace and Lorraine to retain French citizenship following France's defeat in the Franco-Prussian War. It also provided an afternoon's entertainment for a paying audience. The Christmas tree was strongly associated with Alsace, and the event was a spectacle of patriotism, widely reported in the popular press. Through music, verse, and performance, those present mourned “the Lost Provinces” and celebrated the patrie, mobilizing for the Republic the emotions roused by the loss of Alsace and Lorraine. This event highlights the significance of popular cultural practices in developing the “sympathetic emotional regime” that underpinned the successful implantation of the Third Republic.

Cet article analyse un spectacle tombé dans l'oubli, « L'arbre de Noël des Alsaciens-Lorrains », démontrant l'importance de l'émotion en forgeant une culture politique. Cet événement, très couru et largement diffusé dans la presse populaire, se déroulait à Paris chaque Noël de 1872 à 1918. Il aidait les enfants dont les familles, ayant choisi la citoyenneté française, avaient dû quitter l'Alsace et la Lorraine après la guerre de 1870. A travers la musique, la poésie, et l'interprétation dramatique, le spectacle pleurait « les provinces perdues » et les insérait au cœur de la patrie imaginaire française. L'événement, organisé par l'élite républicaine expatriée de l'Alsace et de la Lorraine, constituait une performance collective de l'émotion intense ainsi créée. « L'arbre de Noël des Alsaciens-Lorrains » était un des premiers parmi un large répertoire d'événements culturels de l'époque qui soutenaient la cause républicaine en nourrissant un régime émotionnel favorable.
Comparison of circulating metabolite concentrations in dogs and cats when allowed to freely choose macronutrient intake
Authors: Hall Jean A. , Jackson Matthew I. , Vondran Jodi C. , Vanchina Melissa A. , Jewell Dennis E.
Published: September 2018

Food intake changes circulating metabolite concentrations. Thus, a comparison of circulating metabolites between dogs and cats is necessarily confounded by the composition of foods offered. The objective of this study was to determine differences between dogs and cats when given the opportunity to choose their own macronutrient intake. Four experimental foods with similar palatability, but varying in macronutrient content were prepared for dogs, and four for cats. Foods were available to dogs (n=17) for food intake once a day and to cats (n=27) at all times. Food 1 was high protein; Food 2 was high fat; Food 3 was high carbohydrates; and Food 4 was balanced for macronutrients. By choosing a combination of foods, each animal could individually set its own macronutrient intake. Plasma metabolomics were determined after pets had consumed their food intake of choice for 28 days. Cats had higher concentrations of the essential amino acids histidine, isoleucine, phenylalanine, and valine, but lower concentrations of lysine, methionine, and threonine compared with dogs. Overall, non-essential amino acids were higher in cats. Regarding lipids, cats had increased concentrations of highly polyunsaturated fatty acids after 28 days, although arachidonic acid was consistently higher in dogs. Regarding circulating microbial metabolites, there was more stability for dogs compared with cats (none changed over time in dogs versus 42% changed in cats; P<0.01). Concentrations of urea cycle intermediates, antioxidants, and methylated compounds were also different between species. In conclusion, metabolite differences between dogs and cats reflected differences in species and food choices.
The spatial and temporal dynamics of nuclear RNAi-targeted retrotransposon transcripts in Caenorhabditis elegans
Authors: Ni Julie Zhouli , Kalinava Natallia , Mendoza Sofia Galindo , Gu Sam Guoping
Published: September 2018

Nuclear RNA interference provides a unique approach to the study of RNA-mediated transgenerational epigenetic inheritance. A paradox in the field is that expression of target loci is necessary for the initiation and maintenance of their silencing. How expression and repression are coordinated during animal development is poorly understood. To resolve this gap, we took imaging, deep-sequencing and genetic approaches towards delineating the developmental regulation and subcellular localization of RNA transcripts of two representative endogenous targets, the LTR retrotransposons Cer3 and Cer8. By examining wild-type worms and a collection of mutant strains, we found that the expression and silencing cycle of Cer3 and Cer8 is coupled with embryonic and germline development. Strikingly, endogenous targets exhibit a hallmark of nuclear enrichment of their RNA transcripts. In addition, germline and somatic repressions of Cer3 have different genetic requirements for three heterochromatin enzymes, MET-2, SET-25 and SET-32, in conjunction with the nuclear Argonaute protein HRDE-1. These results provide the first comprehensive cellular and developmental characterization of nuclear RNAi activities throughout the animal reproductive cycle.
S-acylation regulates the trafficking and stability of the unconventional Q-SNARE STX19
Authors: Ampah Khamal K. , Greaves Jennifer , Shun-Shion Amber S. , Asnawi Asral W. , Lidster Jessica A. , Chamberlain Luke H. , Collins Mark O. , Peden Andrew A.
Published: September 2018

STX19 is an unusual Qa-SNARE as it lacks a C-terminal transmembrane domain. However, it is efficiently targeted to post-Golgi membranes. Here, we set out to determine the intracellular localisation of endogenous STX19 and elucidate the mechanism by which it is targeted to membranes. We have found that a pool of STX19 is localised to tubular recycling endosomes where it colocalises with MICAL-L1 and Rab8 (which has Rab8a and Rab8b forms). Using a combination of genetic, biochemical and cell-based approaches, we have identified that STX19 is S-acylated at its C-terminus and is a substrate for several Golgi-localised S-acyltransferases, suggesting that STX19 is initially S-acylated at the Golgi before trafficking to the plasma membrane and endosomes. Surprisingly, we have found that S-acylation is a key determinant in targeting STX19 to tubular recycling endosomes, suggesting that S-acylation may play a general role in directing proteins to this compartment. In addition, S-acylation also protects STX19 from proteosomal degradation, indicating that S-acylation regulates the function of STX19 at multiple levels.

This article has an associated First Person interview with the first author of the paper.
Hyperoxia increases maximum oxygen consumption and aerobic scope of intertidal fish facing acutely high temperatures
Authors: McArley Tristan J. , Hickey Anthony J. R. , Herbert Neill A.
Published: September 2018

Daytime low tides that lead to high temperature events in stranded rock pools often co-occur with algal mediated hyperoxia as a result of strong solar radiation. Recent evidence shows aerobic metabolic scope (MS) can be expanded under hyperoxia in fish but so far this possibility has not been examined in intertidal species despite being an ecologically relevant scenario. Furthermore, it is unknown whether hyperoxia increases the upper thermal tolerance limits of intertidal fish and, therefore the ability to withstand extreme high temperature events. Therefore we measured the metabolic response (mass specific rate of oxygen consumption [ṀO2]) to thermal ramping (21-29°C) and the upper thermal tolerance limit (UTL) of two intertidal triplefin fishes (Bellapiscis medius and Forsterygion lapillum) under hyperoxia and normoxia. Hyperoxia increased maximal oxygen consumption (ṀO2,max) and MS of each species at ambient temperature (21°C) but also after thermal ramping to elevated temperatures such as those observed in rock pools (29°C). While hyperoxia did not provide a biologically meaningful increase in upper thermal tolerance of either species (>31°C under all conditions) the observed expansion of MS at 29°C under hyperoxia could potentially benefit the aerobic performance, hence the growth and feeding potential etc., of intertidal fish at non-critical temperatures. That hyperoxia does not increase upper thermal tolerance in a meaningful way is cause for concern as climate change is expected to drive more extreme rock pool temperatures in the future and this could present a major challenge for these species.
From Ionic Liquids to Solvate Ionic Liquids: Challenges and Opportunities for Next Generation Battery Electrolytes
Authors: Watanabe Masayoshi , Dokko Kaoru , Ueno Kazuhide , Thomas Morgan L
Published: September 2018

Certain concentrated mixtures of lithium salt and solvent (ligand) are no longer simple solutions, but categorized as solvate ionic liquids (SILs), where the solvent strongly coordinates to the cation to form a solvate, a negligible amount of free solvent remains, and thus the SIL consists of the solvate cation and the anion. Typical examples are mixtures of lithium bis(trifluoromethane sulfonyl)amide (Li[TFSA]) and certain glymes The successful formation of a SIL greatly depends on both the ligand and lithium salt structures. To obtain robust and long-lived solvates, a ligand exhibiting a chelate effect is essential and n = 3 and 4 (i.e. triglyme and tetraglyme) are suitable for the formation of lithium solvates. The Lewis basicity of the lithium salt anion also significantly affects the formation of SILs. Specifically, a weak Lewis basicity promotes the formation of a SIL, since the ligand-Li+ interaction overwhelms the Li+-anion interaction. SILs can be diluted with rather low polarity solvents to increase the ionic conductivity, where the solvate structure is maintained even after the dilution. SILs exhibit unique features as electrolytes, including the enhancement of oxidation stability of the component glymes, unique Li+ transport through ligand exchange when interfacial electrochemical reactions are occurring, the inhibition of aluminum corrosion when Al foil is used as a cathode current collector, poorly-solubilizing towards ionic electroactive materials, and electrochemical graphite intercalation reactions. These features greatly enhance the possibility for application of SILs as next generation lithium battery electrolytes. Furthermore, new polymer electrolytes containing SILs have been proposed, simultaneously enabling film-processability, high ionic conductivity, thermal stability, and a wide potential window. Preservation of the solvate structure in the polymeric phases is pivotal to such achievements.
Wealth Shocks and Health Outcomes: Evidence from Stock Market Fluctuations
Authors: Schwandt Hannes
Published: September 2018

Do wealth shocks affect the health of elderly in developed countries? I exploit the booms and busts in the US stock market as a natural experiment that generated considerable gains and losses in the wealth of stock-holding retirees. Using data from the 1998–2011 Health and Retirement Study, I construct wealth shocks as the interaction of stock holdings with stock market changes. These wealth shocks predict wealth changes and strongly affect health outcomes. A 10 percent wealth loss leads to an impairment of 2–3 percent of a standard deviation in physical health, mental health, and survival rates. (JEL D14, G11, G14, I12, J14)
Diabetes and Diet: Purchasing Behavior Change in Response to Health Information
Authors: Oster Emily
Published: September 2018

Individuals with obesity and related conditions are often reluctant to change their diet. Evaluating the details of this reluctance is hampered by limited data. I use household scanner data to estimate food purchase response to a diagnosis of diabetes. I use a machine learning approach to infer diagnosis from purchases of diabetes–related products. On average, households show significant, but relatively small, calorie reductions. These reductions are concentrated in unhealthy foods, suggesting they reflect real efforts to improve diet. There is some heterogeneity in calorie changes across households, although this heterogeneity is not well predicted by demographics or baseline diet, despite large correlations between these factors and diagnosis. I suggest a theory of behavior change that may explain the limited overall change and the fact that heterogeneity is not predictable. (JEL D12, D83, D91, I12, M31)
Identifying Sorting in Practice
Authors: Bartolucci Cristian , Devicienti Francesco , Monzón Ignacio
Published: September 2018

We propose a novel methodology to uncover the sorting pattern in labor markets. We identify the strength of sorting solely from a ranking of firms by profits. To discern the sign of sorting, we build a noisy ranking of workers from wage data. Our test for the sign of sorting is consistent even with noisy worker rankings. We apply our approach to a panel dataset that combines social security earnings records with detailed financial data for firms in the Veneto region of Italy. We find robust evidence of positive sorting. The correlation between worker and firm types is about 52 percent. (JEL J24, J31, J41, J62, L25)
Early developmental arrest and impaired gastrointestinal homeostasis in U12-dependent splicing-defective Rnpc3-deficient mice
Authors: Doggett Karen , Williams Ben B. , Markmiller Sebastian , Geng Fan-Suo , Coates Janine , Mieruszynski Stephen , Ernst Matthias , Thomas Tim , Heath Joan K.
Published: September 2018

Splicing is an essential step in eukaryotic gene expression. While the majority of introns is excised by the U2-dependent, or major class, spliceosome, the appropriate expression of a very small subset of genes depends on U12-dependent, or minor class, splicing. The U11/U12 65K protein (hereafter 65K), encoded by RNPC3, is one of seven proteins that are unique to the U12-dependent spliceosome, and previous studies including our own have established that it plays a role in plant and vertebrate development. To pinpoint the impact of 65K loss during mammalian development and in adulthood, we generated germline and conditional Rnpc3-deficient mice. Homozygous Rnpc3−/− embryos died prior to blastocyst implantation, whereas Rnpc3+/− mice were born at the expected frequency, achieved sexual maturity, and exhibited a completely normal lifespan. Systemic recombination of conditional Rnpc3 alleles in adult (Rnpc3lox/lox) mice caused rapid weight loss, leukopenia, and degeneration of the epithelial lining of the entire gastrointestinal tract, the latter due to increased cell death and a reduction in cell proliferation. Accompanying this, we observed a loss of both 65K and the pro-proliferative phospho-ERK1/2 proteins from the stem/progenitor cells at the base of intestinal crypts. RT-PCR analysis of RNA extracted from purified preparations of intestinal epithelial cells with recombined Rnpc3lox alleles revealed increased frequency of U12-type intron retention in all transcripts tested. Our study, using a novel conditional mouse model of Rnpc3 deficiency, establishes that U12-dependent splicing is not only important during development but is indispensable throughout life.
The multistructural forms of box C/D ribonucleoprotein particles
Authors: Yu Ge , Zhao Yu , Li Hong
Published: September 2018

Structural biology studies of archaeal and yeast box C/D ribonucleoprotein particles (RNPs) reveal a surprisingly wide range of forms. If form ever follows function, the different structures of box C/D small ribonucleoprotein particles (snoRNPs) may reflect their versatile functional roles beyond what has been recognized. A large majority of box C/D RNPs serve to site-specifically methylate the ribosomal RNA, typically as independent complexes. Select members of the box C/D snoRNPs also are essential components of the megadalton RNP enzyme, the small subunit processome that is responsible for processing ribosomal RNA. Other box C/D RNPs continue to be uncovered with either unexpected or unknown functions. We summarize currently known box C/D RNP structures in this review and identify the Nop56/58 and box C/D RNA subunits as the key elements underlying the observed structural diversity, and likely, the diverse functional roles of box C/D RNPs.
Cell–cell adhesion interface: orthogonal and parallel forces from contraction, protrusion, and retraction
Authors: Tang Vivian W.
Published: September 2018

The epithelial lateral membrane plays a central role in the integration of intercellular signals and, by doing so, is a principal determinant in the emerging properties of epithelial tissues. Mechanical force, when applied to the lateral cell–cell interface, can modulate the strength of adhesion and influence intercellular dynamics. Yet the relationship between mechanical force and epithelial cell behavior is complex and not completely understood. This commentary aims to provide an investigative look at the usage of cellular forces at the epithelial cell–cell adhesion interface.
Design and implementation of semester long project and problem based bioinformatics course
Authors: Saarunya Geetha , Ely Bert
Published: September 2018

Background: Advancements in ‘high-throughput technologies’ have inundated us with data across disciplines. As a result, there is a bottleneck in addressing the demand for analyzing data and training of ‘next generation data scientists’.

Methods: In response to this need, the authors designed a single semester “Bioinformatics” course that introduced a small cohort of students at the University of South Carolina to methods for analyzing data generated through different ‘omic’ platforms using variety of model systems.  The course was divided into seven modules with each module ending with a problem.

Results: Towards the end of the course, the students each designed a project that allowed them to pursue their individual interests. These completed projects were presented as talks and posters at ISCB-RSG-SEUSA symposium held at University of South Carolina.

Conclusions: An important outcome of this course design was that the students acquired the basic skills to critically evaluate the reporting and interpretation of data of a problem or a project during the symposium.
FUT2 secretor genotype and susceptibility to infections and chronic conditions in the ALSPAC cohort
Authors: Azad Meghan B. , Wade Kaitlin H. , Timpson Nicholas J.
Published: September 2018

Background:TheFUT2(fucosyltransferase-2) gene determines blood group secretor status. Being homozygous for the inactive “non-secretor” rs601338(A) allele confers resistance to certain infections (e.g.Norovirus,Rotavirus) and susceptibility to others (e.g.Haemophilus influenza,Streptococcus pneumonia). Non-secretors also have an increased risk of type 1 diabetes and inflammatory bowel disease. We examinedFUT2genotype, infections and chronic conditions in a population-based cohort.

Methods:We studied 7,582 pregnant women from the ALSPAC pregnancy cohort. Infections (measles, mumps, chicken pox, whooping cough, meningitis, herpes, gonorrhea and urinary infections) and chronic conditions (kidney disease, hypertension, diabetes, rheumatism, arthritis, psoriasis, hay fever, asthma, eczema and allergies) were self-reported.FUT2secretor status was determined from the rs601338 genotype. ABO blood type was obtained from clinical records.

Results:Overall, 1920 women (25.3%) were homozygous for the non-secretor allele (AA). Secretor status was associated with mumps, with 68% of non-secretors experiencing this infection, compared to 48% of secretors (RR, 1.40; 95% CI, 1.34–1.46). A weaker association was observed for measles infection (76% vs. 72%; RR, 1.05; 95% CI, 1.02–1.09). Non-secretors also experienced an increased risk of kidney disease (5.4% vs. 3.9%; RR, 1.39; 95% CI, 1.11–1.75). Independent of secretor status, AB blood type was a risk factor for mumps (RR 1.15; 95%CI, 1.03, 1.28 compared to type O). We found no evidence of interaction between secretor status and blood type.  For some conditions, including asthma and arthritis,FUT2heterozygosity (GA) appeared to confer an intermediate phenotype. There was no strong evidence of association between secretor status and other infections or chronic conditions, although statistical power was limited for rare outcomes.

Conclusion:Our results identify an association betweenFUT2secretor status and self-reported kidney disease, and confirm a recently reported association with susceptibility to mumps infection. The clinical implications of these associations warrant further investigation.
ИНТЕНСИФИКАЦИЯ ПРОЦЕССА ОБУЧЕНИЯ ПРОФЕССИОНАЛЬНО ОРИЕНТИРОВАННЫМ ИНОЯЗЫЧНЫМ КОММУНИКАТИВНЫМ НАВЫКАМ СРЕДСТВАМИ ОНЛАЙН ТЕХНОЛОГИЙ
Authors: Nevolina Ksenia Viktorovna , Podkamennaya Elizaveta Vasilievna , Fetisova Svetlana Anatolievna
Published: September 2018

Цель данной работы заключается в систематизации теоретических и практических аспектов проблемы внедрения онлайн технологий в процесс обучения профессионально-ориентированным иноязычным коммуникативным навыкам студентов неязыковых вузов.Материалы и методы исследования. Применяемый метод анализа и обобщения, а также логический метод позволяют суммировать теоретические наработки в области инновационных направлений преподавания иностранных языков. Базой для практической части исследования являются метод наблюдения и метод эксперимента.Результаты исследования. Анализ научных работ, посвященных проблеме использования интерактивных форм обучения, послужили отправной точкой для авторской разработки процедуры обучения организации и проведения вебинаров на английском языке, эффективность которой была доказана экспериментальным путем.Обсуждение и заключения. Практическая значимость статьи заключается в универсальном характере алгоритма применения вебинара как интерактивной образовательной технологии. Вебинар рассматривается как интерактивная форма, организуемая и проводимая самими студентами для совершенствования навыков их профессионального общения. Результаты проведенного исследования могут быть полезны и интересны как специалистам в области высшего образования и студентам, а также послужить материалом для дальнейшего совершенствования инновационных форм интерактивного обучения.
КОМПЕТЕНТНОСТНЫЙ ПОДХОД И СРЕДСТВА ОЦЕНКИ КАЧЕСТВА ПОДГОТОВКИ СТУДЕНТОВ В АДАПТИВНЫХ ЭЛЕКТРОННЫХ ОБУЧАЮЩИХ КУРСАХ
Authors: Vainshtein Yulia Vladimirovna , Shershneva Viktoriya Anatol’evna , Vainshtein Vitalii Isaakovich , Kosmidis Irina Fedorovna
Published: September 2018

Цель. В контексте тенденций развития компетентностного подхода и персонифицированного электронного образовательного пространства возникает необходимость создания и развития новых подходов к оценке качества результатов обучения. Настоящая работа посвящена созданию комплекса оценочных средств, обеспечивающих формирование компетенций и оценку образовательных результатов обучения математике в адаптивных электронных обучающих курсах.Метод и методология проведения работы. Основу исследования образуют эмпирический и теоретический методы.Результаты. В работе рассмотрен компетентностный подход, понятия компетенции и компетентности. Обозначены образовательные технологии как способ формирования компетенций. Выделены уровни формирования математической компетенции. Представлены средства оценивания учебных достижений и компетенций студентов в адаптивном курсе по дисциплине «Дискретная математика»: база тестовых заданий и портфолио учебных достижений. Предложенные средства обеспечивают количественный и качественный уровень измерения компетенций. Обозначены преимущества применения предложенных оценочных средств.Область применения результатов. Результаты работы могут быть использованы при разработке адаптивных электронных обучающих курсов обучения математике в рамках компетентностного подхода.
Mental rotation task in bipolar disorder
Authors: Chrobak Adrian , Jeziorko Szymon , Tereszko Anna , Janeczko Weronika , Arciszewska Aleksandra , Siuda-Krzywicka Katarzyna , Starowicz-Filip Anna , Siwek Marcin , Dudek Dominika
Published: September 2018

Cel pracy

Choroba Afektywna Dwubiegunowa (ChAD) istotnie wpływa na poziom dysfunkcji poznawczych i motorycznych. Badania nad funkcjami poznawczymi w Chorobie Afektywnej Dwubiegunowej wskazują między innymi na występowanie deficytów w zakresie przetwarzania wzrokowo – przestrzennego i pamięci wzrokowo – przestrzennej. Dotychczas w badaniach z udziałem pacjentów z ChAD nie wykorzystywano jednak Testu Rotacji Mentalnych (Mental Rotation Task) do oceny tych funkcji. Naszym celem było wprowadzenie tej metody i ocena wspomnianych zaburzeń w grupie pacjentów z ChAD w eutymii.

Metoda

W badaniu wzięło udział 31 pacjentów z ChAD w fazie eutymii oraz 27 zdrowych ochotników dobranych pod względem wieku i lat edukacji. Każdy z uczestników wykonywał komputerową wersję Testu Rotacji Mentalnych. Badani mieli za zadanie porównywać dwie zrotowane względem siebie figury i ocenić ich podobieństwo, wskazując czy figury są identyczne, czy też stanowią swoje lustrzane odbicie.

Wyniki

Test wykazał istotnie dłuższy czas reakcji w grupie pacjentów z ChAD w warunkach zrotowania figur pod kątem -90, -45, 45, 90 stopni oraz w przypadku braku rotacji. Dla kątów -135, 135 i 180 stopni nie odnotowano istotnej różnicy między grupami. Poziom poprawności wykonania był istotnie niższy w grupie pacjentów niż w grupie kontrolnej zarówno w wyniku ogólnym jak i w poszczególnych warunkach zadania. Korelacja między średnim czasem reakcji a poprawnością okazała się nieistotna.

Wnioski

Nasze wyniki są zgodne z literaturą opisującą deficyty wzrokowo-przestrzenne w ChAD. Badanie to jako pierwsze prezentuje deficyty rotacji umysłowych u pacjentów z ChAD w fazie eutymii.
Predictors of Clinically Significant Echocardiography Findings in Older Adults with Syncope: A Secondary Analysis
Authors: Probst Marc A. , Gibson Thomas A. , Weiss Robert E. , Yagapen Annick N. , Malveau Susan E. , Adler David H. , Bastani Aveh , Baugh Christopher W. , Caterino Jeffrey M. , Clark Carol L. , Diercks Deborah B. , Hollander Judd E. , Nicks Bret A. , Nishijima Daniel K. , Shah Manish N. , Stiffler Kirk A. , Storrow Alan B. , Wilber Scott T. , Sun Benjamin C.
Published: September 2018

BACKGROUND

Syncope is a common reason for visiting the emergency department (ED) and is associated with significant healthcare resource utilization.

OBJECTIVE

To develop a risk‐stratification tool for clinically significant findings on echocardiography among older adults presenting to the ED with syncope or nearsyncope.

DESIGN

Prospective, observational cohort study from April 2013 to September 2016

SETTING

Eleven EDs in the United States

PATIENTS

We enrolled adults (≥60 years) who presented to the ED with syncope or near‐syncope who underwent transthoracic echocardiography (TTE).

MEASUREMENTS

The primary outcome was a clinically significant finding on TTE. Clinical, electrocardiogram, and laboratory variables were also collected. Multivariable logistic regression analysis was used to identify predictors of significant findings on echocardiography.

RESULTS

A total of 3,686 patients were enrolled. Of these, 995 (27%) received echocardiography, and 215 (22%) had a significant finding on echocardiography. Regression analysis identified five predictors of significant findings: (1) history of congestive heart failure, (2) history of coronary artery disease, (3) abnormal electrocardiogram, (4) high‐sensitivity troponin‐T >14 pg/mL, and 5) N‐terminal pro B‐type natriuretic peptide >125 pg/mL. These five variables make up the ROMEO (Risk Of Major Echocardiography findings in Older adults with syncope) criteria. The sensitivity of a ROMEO score of zero for excluding significant findings on echocardiography was 99.5% (95% CI: 97.4%‐99.9%) with a specificity of 15.4% (95% CI: 13.0%‐18.1%).

CONCLUSIONS

If validated, this risk‐stratification tool could help clinicians determine which syncope patients are at very low risk of having clinically significant findings on echocardiography.

FUNDING

This project was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Number R01 HL111033. Dr. Probst is supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Number K23HL132052‐02.
Risk Averse Shortest Paths: A Computational Study
Authors: Chicoisne Renaud , Ordóñez Fernando , Espinoza Daniel
Published: September 2018

In this work we consider the shortest path problem with uncertainty in arc lengths and convex risk measure objective. We explore efficient implementations of sample average approximation (SAA) methods to solve shortest path problems when the conditional value at risk and entropic risk measures are used and there is correlation present in the uncertain arc lengths. Our work explores the use of different decomposition techniques to achieve an efficient implementation of SAA methods for these nonlinear convex integer optimization problems. A computational study shows the effect of geometry, uncertainty correlation and variance, and risk measure parameters on efficiency and accuracy of the methods developed.

Data and the online supplement are available at https://doi.org/10.1287/ijoc.2017.0795 .
INTUITIONISTIC FUZZY ORIGINATED TYPE-2 FUZZY AHP
Authors: Kahraman Cengiz , Öztayşi Başar , Çevik Onar Sezi , Doğan Onur
Published: September 2018

Intuitionistic fuzzy sets (IFS) proposed by Atanassov (1983, 1986) are a generalization of ordinary fuzzy sets. They incorporate the degree of hesitation which is defined as 1 minus the sum of membership and non-membership degrees. Type-2 fuzzy sets were first introduced by Zadeh (1975) as an extension of the concept of an ordinary fuzzy set. Type-2 fuzzy sets have grades of membership that are themselves fuzzy. The membership function of a type-2 fuzzy set is three-dimensional, and it is the new third dimension that provides additional degrees of freedom for handling uncertainties. An intuitionistic fuzzy set can be converted to a Type-2 fuzzy set by subtracting its non-membership function from 1. Thus, an intuitionistic fuzzy multi-criteria decision making problem can be solved by using type-2 fuzzy multi-criteria decision making techniques. In this paper, an intuitionistic fuzzy originated interval type-2 fuzzy AHP method is developed and applied to the technology selection problem of a damless hydroelectric power plant. Damless hydroelectric power plants are environmentally friendly and sustainable energy production systems. Several criteria and damless technology alternatives along the Sakarya River in Turkey are considered. Linguistic evaluations are considered in this multi-criteria damless technology selection problem.
Minimal intervention in oral cancer management: idealistic or realistic?
Authors: Thomson Peter
Published: September 2018

For many years, early diagnosis and management of OSCC have been areas of clinical practice where variability in decision-making and lack of high-quality evidence confounded treatment initiatives. Could an improved understanding of minimal interventional therapy offer an opportunity to improve clinical care?
Redefining Publics:
Mosireen, State Crime and the Rise of a Digital Public Sphere
Authors: Kasm Saeb
Published: September 2018

The article traces the rise of
Mosireen, a non-profit media collective, within the parameters of revolutionary and post-revolutionary Egypt's public sphere. It highlights how the
Mosireen Collective strategically co-opted the infrastructure of the internet during critical periods of the Egyptian revolution as a tool of resistance to fight injustice, expose human rights violations and restore some semblance of accountability. Moreover, it explores
Mosireen's innovative online/offline digital activism which enabled formerly marginalized publics to access new modes of information and challenge elite-driven discourses, thereby contributing to the “democratization” of the public sphere. The article further investigates
Mosireen's emancipatory use of technology where the creation of an oppositional framework not only sustained “resistance from below” movements but also seemed to open up new potentialities for counter-hegemonic spaces and alternative discursive frameworks of society. The article provides a rich case study in how ideological struggles and questions of power are interpreted within the broader realm of Egyptian civil society with a particular focus on the power of visual production and its effect on the development of digital counter-publics. Finally, the limitations of the public sphere under neo-liberal capitalism are contextualized and critiqued within the context of the
Mosireen Collective and broader digital resistance movements.
Care ethics and International Relations: challenging rationalism in global ethics
Authors: Robinson Fiona
Published: September 2018

This article explores recent scholarship in the area of care ethics and International Relations. The article begins by tracing the journey of care ethics into the realm of the international or ‘the global’, and then moves on to elaborate on recent scholarship in the area of care ethics in International Relations. Through a discussion of three key areas – violence and conflict, the body, and the ‘pluriverse’ – I argue that feminist care ethics has the potential to offer a way forward in the light of growing critiques of moral rationalism in the international ethics/International Political Theory literature.
Interrogating theories of care in the Indian context
Authors: Mahadevan Kanchana
Published: September 2018

Nussbaum’s capabilities approach highlights the need for integrating vulnerability, dependency and care work with liberal principles of individuality and rationality. However, capabilities offer a statist, juridical and formal model of objectified care, whose adoption would lead to greater paternalism, especially in the context of public welfare institutions in India. This article argues that one needs to move beyond liberal theory, while engaging with vulnerability and care work in institutional contexts. It defends informal care as a multilayered practice in public sector institutions in India, to which deliberation is central. It acknowledges the inevitability of flexibility, interdependence, plurality and particularity in informal caregiving practice.
Macau wine festivalscape: Attendees’ satisfaction and behavioural intentions
Authors: Choe Jaeyeon , Qian Xinyi , O’ Regan Michael , Yap Matthew H. T.
Published: September 2018

This article explores festivalscape factors at an international wine and dine festival in Macau, a Special Administrative Region (SAR) of the People’s Republic of China. The main goal of this study is to assess satisfaction with various festivalscape factors and identify the relations between the festivalscape construct and behavioural intention. The article also explores whether festivalscape factors are influenced by attendee attributes. The study found that festivalscape scores had significant positive effects on perceived value for money, overall satisfaction and intention to revisit. Perceived value for money and overall satisfaction had significantly positive effect on intention to revisit and becoming a repeat visitor. The findings provide valuable insights into the festivalscape factors that influence repeat visitation to an emergent cultural-type event in greater China. We also present recommendations for the growth of the city wine and dine festival, so as to help promote and diversify Macau as a world tourism and leisure centre.
The hospitality model revisited: Developing a hospitality model for today and tomorrow
Authors: Lombarts Angelique
Published: September 2018

The main purpose of this research note is to propose a revised version of Reuland, Choudry and Fagel’s hospitality model; the original model took into account the tangible elements such as product and environment and the intangible elements such as behaviour (from both the managerial and the customer’s perspective). The transaction was the actual interaction. The renewed and broadened interest in hospitality demands an updated and broadly applicable hospitality model. To adapt the hospitality model, the concept of hospitality was studied, along with contemporary societal developments of sustainable development (SD) and stakeholder relation management (SRM). The adaptation should meet the needs of present generations without compromising those of future generations. The complexity of today’s networked world was also taken into account. This resulted in a revised model that builds on four sustainability pillars: economical, ecological, social and cultural. It proposes considering hospitality as an experience in which a myriad of stakeholders may interact, involving a variety of products and taking place in various contexts. The main limitation of this note is that this conceptual elaboration has yet to be proven in practice. Therefore, the note ends with suggestions for further research into the applicability of the model in other fields such as healthcare and city management.
Cytotoxicity of three-dimensional paper-based models from a three-dimensional paper-based printer
Authors: Kozakiewicz Marcin , Szymor Piotr , Olszewski Raphael
Published: September 2018

Objective: Our study aimed to determine the possibility of using models created with a low-cost, paper based 3D printer in an operating room. Therefore influence of different methods of sterilization on models was tested and cytotoxicity of generated models was determined. Material and methods: 30 cuboids divided into three groups were used for verification of shape stability after sterilization. Each group was sterilized either with: Ethylene oxide in temperature 55˚C, Hydrogen peroxide gas plasma in temperature 60˚C or Gamma irradiation at 21˚C, 25kGy. Each cuboid was measured using calliper three times before and three times after sterilization. Results were analysed statistically in Statgraphics Plus. Statistical significance was determined as p< 0.05. Sixty cylinders divided into six groups were used for cytotoxicity tests. Three of those groups were covered before sterilization with 2-octyl-cyanoacrylate. Each group was sterilized with one of the previously described methods. Cytotoxicity was tested by Nanostructural and Molecular Biophysics Laboratory in Technopark Lodz using normal adult human dermal fibroblasts. Survival of cells was tested using spectrophotometry with XTT and was defined as ratio of absorbency of tested probe to absorbency of control probe. Calcein/Ethidium dyeing test was performed according to LIVE/DEAD Viability/Cytotoxicity Kit protocol. Observation was done under Olympus GX71 fluorescence microscope. Results: There was no statistically significant difference for established statistical significance p=0.05 in cuboids dimensions before and after sterilization regardless of sterilization method. In XTT analysis all samples showed higher cytotoxicity against normal, human, adult dermal fibroblast culture when compared to positive control. ANOVA statistical analysis confirmed that 2-octyl cyanoacrylate coating of paper model improved biological behaviour of the material. It decreased cytotoxicity of the model independently of sterilization method. In calcein/ethidium dyeing test due to the high fluorescence of the background caused by cylinders of analysed substance it was impossible to perform the exact analysis of the number of marked cells. Conclusions: Acquired results allow to conclude that Mcor Technology Matrix 300 3D paper-based models can be used in operating room only if covered with cyanoacrylate tissue adhesive. Nemesis relevance: We found no statistically significant difference in cuboids dimensions before and after sterilization regardless of sterilization method. Three-dimensional paper-based models present with high cytotoxicity without coating.
Kate O’Connor, MOOCs, Institutional Policy and Change Dynamics in Higher Education (Idea MOOCs, polityka instytucjonalna i zmiana dynamiki rozwoju szkolnictwa wyższego), „Higher Education” 2014, vol. 68, iss. 5 (opr. Monika Kotowska-Lewińska)
Authors: Kotowska-Lewińska Monika
Published: September 2018

Kate O’Connor, MOOCs, Institutional Policy and Change Dynamics in Higher Education (Idea MOOCs, polityka instytucjonalna i zmiana dynamiki rozwoju szkolnictwa wyższego), „Higher Education” 2014, vol. 68, iss. 5 (opr. Monika Kotowska-Lewińska)
Ryszard Piotrowicz, Asylum Seekers, Good Faith and the State (Osoby ubiegające się o ochronę międzynarodową, dobra wiara i państwo), „International Journal on Minority and Group Rights” 2013, vol. 20, iss. 2 (opr. Agnieszka Narożniak)
Authors: Narożniak Agnieszka
Published: September 2018

Ryszard Piotrowicz, Asylum Seekers, Good Faith and the State (Osoby ubiegające się o ochronę międzynarodową, dobra wiara i państwo), „International Journal on Minority and Group Rights” 2013, vol. 20, iss. 2 (opr. Agnieszka Narożniak)
Dallal Stevens, What Do We Mean by Protection? “International Journal on Minority and Group Rights” 2013, vol. 20, iss. 2 (by Agnieszka Narożniak)
Authors: Narożniak Agnieszka
Published: September 2018

Dallal Stevens, What Do We Mean by Protection? “International Journal on Minority and Group Rights” 2013, vol. 20, iss. 2 (by Agnieszka Narożniak)
Kilka uwag o responsywności prawa podatkowego na przykładzie urzędowych interpretacji prawa podatkowego
Authors: Kola Jarosław , Pest Przemysław
Published: September 2018

The article is an attempt to look at the development of Polish tax law through the prism of the concept of law development proposed by Ph. Selznick and Ph. Nonet. In the study Law and Society in Transition. Towards Responsive Law they distinguished three stages of evolution of legal systems: repressive, autonomous and responsive. The focus of the article is on the institution of the official interpretation of tax law, because an analysis of the transformation of the legal system allows to capture trends that are present in the development of its individual institutions as well as social relationships among its recipients. By indicating the evolution of official in terpretations of tax law in its two basic functions – those of informing and those of guaranteeing (protective) – the authors point to a wider context of the development of tax law to show whether and how changes in the normative regulation of official interpretations of tax law may affect the shape of the relationship between a tax payer and tax administration, where the perspective of the analysis of demand is the responsiveness of law. An analysis of the regulation of an official interpretation of tax law leads to the conclusion that due to the assigned ratio legis this interpretation must characterise them as corresponding mainly to the autonomous model. At the same time a responsive model of law does not undermine the autonomous model attributes. Thus if we were to accept that the provision of interpretation corresponds to the autonomous model, it would not be possible to note that it also has attributes that make it a responsive model. Irrespective of the fact that there is no element of negotiation, it is based on the interaction between the taxpayer and the tax administration. As part of this interaction, tax administration responds to the reported social need in terms of the ambiguity of law, which de iure – not least because of the possibility of bringing an action against the content of interpretation – takes place in the framework of a communication situation that is free from external coercion.
Filip Elżanowski, Situation of an energy plant in legal proceedings related to energy regulations, Wydawnictwo Wolters Kluwer, Warszawa 2015
Authors: Gajewski Sebastian
Published: September 2018

Filip Elżanowski, Situation of an energy plant in legal proceedings related to energy regulations, Wydawnictwo Wolters Kluwer, Warszawa 2015
Jakub Pawliczak, Zarejestrowany związek partnerski a małżeństwo, seria Monografie LEX, Wydawnictwo Wolters Kluwer SA, Warszawa 2014, ss. 400, ISBN 978-83-264-3370-2
Authors: Jankowska Paulina
Published: September 2018

Jakub Pawliczak, Zarejestrowany związek partnerski a małżeństwo, seria Monografie LEX, Wydawnictwo Wolters Kluwer SA, Warszawa 2014, ss. 400, ISBN 978-83-264-3370-2