bluuebunny/crossref_metadata_2025 huggingface dataset:
Los Instrumentos de Planeamiento Urbanístico en España: estudio comparado (II)
Authors: Hernández-Partal Sonia
Published: February 2022

El procedimiento de elaboración, tramitación y aprobación de los instrumentos de planeamiento general constituye uno de los pilares fundamentales del urbanismo español y el encargado de dotarlo de las garantías consustanciales a la protección de los derechos y deberes de los propietarios, el respeto de la normativa sectorial y el ejercicio de la participación ciudadana, entre otros. No obstante, el análisis de su regulación en el vigente marco normativo conformado por las diecisiete legislaciones autonómicas, refuerza las conclusiones extraídas en la primera parte de este estudio que pone de manifiesto, además de su elevada heterogeneidad formal y la ausencia de innovaciones sustanciales a nivel de contenido, su extrema vulnerabilidad vinculada a un alto nivel de complejidad y rigidez que termina por convertir a estos procedimientos en un largo camino de controles preventivos que no siempre consiguen los objetivos que se buscan y que, con frecuencia, acaban por generar inseguridad jurídica. A dicha complejidad se une además una extensa documentación que, si bien en su mayor parte es continuista con la tradición urbanística, en ocasiones se ve condicionada por el carácter normativo que le atribuyen algunas leyes autonómicas, lo que ahonda en una problemática que ya está identificada como alguna de las más relevantes del urbanismo español.
Le Phenix Po�te et les Alou�tes
Authors: Raimondo Riccardo
Published: February 2022

La po�sie de P�trarque et le p�trarquisme qui en est d�riv� constituent une mati�re inestimable et un champ fertile pour comprendre les sources des identit�s et des cultures europ�ennes. Il est donc crucial d�examiner les �tudes p�trarquiennes au regard de nouvelles notions critiques telles que la transculturalit� ou la transnationalit�. L�exemple embl�matique fran�ais constitue un champ d�enqu�te privil�gi� pour d�crire ce que l�auteur d�finit comme le � mouvement migrant � du p�trarquisme europ�en. Gr�ce � l�application de nouvelles th�ories et m�thodologies transdisciplinaires, cet ouvrage offre au public la possibilit� de d�couvrir la richesse des traductions fran�aises des Rerum vulgarium fragmenta sur une p�riode tr�s vaste qui court du XVIe au XXIe si�cle. Au-del� de l�ambition d�un travail d��rudition, ce livre est surtout le fruit d�une enqu�te intime sur des formes arch�typales qui s�incarnent dans l�histoire des id�es et des litt�ratures. L�histoire de la traduction et des traductions n�est pas seulement une histoire des textes, mais aussi un r�cit des imaginaires qui les ont travers�s.
Collateral-resistance to estrogen and HER-activated growth is associated with modified AKT, ERα, and cell-cycle signaling in a breast cancer model
Authors: Moore Kate M. , Cerqueira Vera , MacLeod Kenneth G. , Mullen Peter , Hayward Richard L. , Green Simon , Harrison David J. , Cameron David A. , Langdon Simon P.
Published: February 2022

Aim: A model of progressively endocrine-resistant breast cancer was investigated to identify changes that can occur in signaling pathways after endocrine manipulation.
Methods: The MCF7 breast cancer model is sensitive to estrogens and anti-estrogens while variant lines previously derived from wild-type MCF7 are either relatively 17β-estradiol (E2)-insensitive (LCC1) or fully resistant to estrogen and anti-estrogens (LCC9).
Results: In LCC1 and LCC9 cell lines, loss of estrogen sensitivity was accompanied by loss of growth response to transforming growth factor alpha (TGFα), heregulin-beta and pertuzumab. LCC1 and LCC9 cells had enhanced AKT phosphorylation relative to MCF7 which was reflected in downstream activation of phospho-mechanistic target of rapamycin (mTOR), phospho-S6, and phospho-estrogen receptor alpha Ser167 [ERα(Ser167)]. Both AKT2 and AKT3 were phosphorylated in the resistant cell lines, but siRNA knockdown suggested that all three AKT isoforms contributed to growth response. ERα(Ser118) phosphorylation was increased by E2 and TGFα in MCF7, by E2 only in LCC1, but by neither in LCC9 cells. Multiple alterations in E2-mediated cell cycle control were identified in the endocrine-resistant cell lines including increased expression of MYC, cyclin A1, cyclin D1, cyclin-dependent kinase 1 (CDK1), CDK2, and hyperphosphorylated retinoblastoma protein (ppRb), whereas p21 and p27 were reduced. Estrogen modulated expression of these regulators in MCF7 and LCC1 cells but not in LCC9 cells. Seliciclib inhibited CDK2 activation in MCF7 cells but not in resistant variants; in all lines, it reduced ppRb, increased p53 associated responses including p21, p53 up-regulated modulator of apoptosis (PUMA), and p53 apoptosis-inducing protein 1 (p53AIP1), inhibited growth, and produced G2/M block and apoptosis.
Conclusions: Multiple changes occur with progression of endocrine resistance in this model with AKT activation contributing to E2 insensitivity and loss of ERα(Ser118) phosphorylation being associated with full resistance. Cell cycle regulation is modified in endocrine-resistant breast cancer cells, and seliciclib is effective in both endocrine-sensitive and resistant diseases.
Stability Analysis of the Matrix-vector Product (via FFT) for a Toeplitz-like Matrix
Authors: Favati Paola , Menchi Ornella
Published: February 2022

In this paper the numerical stability of the matrix-vector product, performed via FFT, is analyzed for the case of the Toeplitz-like matrices. The error appears to depend on the magnitude of the generators of the matrix. The numerical experimentation confirms the theoretical result.
Clinical and morphological aspects of the combination of tuberculosis and lung cancer
Authors: Stogova Natalia
Published: February 2022

The purpose of the study. To establish the features of clinical and radiological manifestations of the disease and the effectiveness of methods of examination of patients with a combination of lung cancer and tuberculosis.
Material and methods. The analysis of the case histories of 38 lung cancer patients aged 42 to 82 years, 31 men and 7 women who were in the Voronezh regional tuberculosis dispensary in 1995–2019 was carried out. In 20 patients, cancer was combined with active pulmonary tuberculosis (group 1) and in 18 patients with inactive residual changes in the lungs after earlier tuberculosis (group 2). Research methods: clinical, laboratory, instrumental, morphological, statistical using the SPSS Statistics 10 program.
Results. In group 1, focal pulmonary tuberculosis in the infiltration phase was detected in 2 (10.0%), infiltrative tuberculosis — in 18 (90.0%) patients. Central lung cancer was found in 12 (60.0%), peripheral — in 8 (40.0%) patients. Lung cancer was detected in stage I in 5 (25.0%), in stage II in 6 (30.0%), in stage III in 4 (20.0%) and in stage IV in 5 (25.0%) patients. In group 2, central lung cancer was detected in 7 (38.9%), peripheral lung cancer in 11 (61.1%) patients. Lung cancer was detected in stage I in 3 (16.7%), in stage II in 2 (11.1%), in stage III in 3 (16.7%) and in stage IV in 10 (55.5%) patients.
Conclusion. The combination of lung cancer and tuberculosis is more often observed in men, more often in the elderly and senile age. Cancer occurs in the lung on the side of the tuberculous lesion with active tuberculosis in 75.0%, with inactive — in 83.3% of cases. Microbiological and morphological methods of investigation are the most effective for verifying the diagnosis of a combination of tuberculosis and lung cancer.
The combination of late radiation injuries of the pelvic organs in a patient after chemoradiotherapy of cervical cancer II b (cT2bN0M0) and their treatment (clinical example)
Authors: Sycheva Inna , Kaprin Andrey , Ivanov Sergey
Published: February 2022

A clinical case of successful conservative treatment of radiation injuries (RI) of the pelvic organs (late radiation ulcerative-necrotic epithelitis of the vagina – ulceration of the vagina, late radiation ulcerative-necrotic cystitis and late radiation hemorrhagic rectitis) after CRT cervical cancer IIB art. (cT2bN0M0) is presented. There are still no standards for the treatment of RI either in our country or abroad. After treatment, the patient is observed in our department for 5 years (every six months) without relapses and progression of the main oncological disease and exacerbations of radiation injuries. This pathology is an important object for study. In the absence of the effectiveness of conservative treatment, endoscopic or subsequent surgical intervention is indicated. Keywords: cervical cancer; chemoradiotherapy; radiation injuries; vaginal radiation epithelitis (ulceration of the vagina); radiation cystitis; radiation rectitis (radiation proctitis).
Compliance nas Relações de Consumo: Análise das Diretrizes e Padrões Éticos da Rede Norte-Americana De Supermercados Whole Foods
Authors: Bandeira Gonçalo Nicolau Cerqueira Sopas De Mello , Garbaccio Grace Ladeira , Rodrigues Pedro Henrique Gonçalves
Published: February 2022

O presente trabalho visa analisar as diretrizes institucionais, padrões éticos e de conduta da rede multinacional norte-americana de supermercados Whole Foods, bem como suas políticas mercantis, de forma a aprofundar em um novo paradigma da atividade empresarial com base no compliance das relações de consumo. Neste contexto, o modelo empresarial em exame engloba um comércio apenas de produtos naturais, orgânicos e sem aditivos artificiais, aliando valores intrínsecos e comportamentos extrínsecos, de forma a envolver um papel institucional e de protagonista da função social da empresa, sobretudo no elo de confiança com fornecedores e consumidores. Assim, por meio de uma síntese científica, este artigo utilizar-se-á o método de pesquisa de exploração bibliográfica, com base na análise de referências de artigos e estudos bibliográficos pertinentes.
Ein E-Learning-Konzept zum forschenden Lernen/An e-learning concept for research-based learning
Authors: Rösgen Judith Christine , Kuhlmann Wolfram , Lange Jörg , Seyfarth André
Published: February 2022

Im Bauingenieurstudium an der Technischen Hochschule Köln können die Studierenden der Fachrichtung Konstruktiver Ingenieurbau sowohl im Bachelor- als auch im Masterstudium Projektmodule wählen, in denen sie das wissenschaftliche Arbeiten und die Nutzung von Messtechnik lernen und anwenden sollen.

 

Im Rahmen eines Forschungsprojektes zu fußgängerinduzierten Schwingungen wurde ein E-Learning-Konzept entwickelt, erprobt und analysiert, welches eine gute Verknüpfung zwischen Lehre und Forschung ermöglicht. Die Studierenden können eine kleine Teilfragestellung aus dem Forschungsthema behandeln und die Ergebnisse werden in Form eines Wikis für nachfolgende Gruppen nutzbar gemacht. Die Analyse und Bewertung des Konzeptes konzentrieren sich auf die Bedingungen, (wie beispielsweise die Leistungsmotivation der Studierenden), die Verlaufsprozesse sowie die Akzeptanz und Wirkung des Konzeptes.
Systematic studies into uniform synthetic protein nanoparticles
Authors: Habibi Nahal , Mauser Ava , Raymond Jeffery E , Lahann Joerg
Published: February 2022

Nanoparticles are frequently pursued as drug delivery carriers due to their potential to alter the pharmacological profiles of drugs, but their broader utility in nanomedicine hinges upon exquisite control of critical nanoparticle properties, such as shape, size, or monodispersity. Electrohydrodynamic (EHD) jetting is a probate method to formulate synthetic protein nanoparticles (SPNPs), but a systematic understanding of the influence of crucial processing parameters, such as protein composition, on nanoparticle morphologies is still missing. Here, we address this knowledge gap by evaluating formulation trends in SPNPs prepared by EHD jetting based on a series of carrier proteins and protein blends (hemoglobin, transferrin, mucin, or insulin). In general, blended SPNPs presented uniform populations with minimum diameters between 43 and 65 nm. Size distributions of as-jetted SPNPs approached monodispersity as indicated by polydispersity indices (PDISEM) ranging from 0.11–0.19. Geometric factor analysis revealed high circularities (0.82–0.90), low anisotropy (<1.45) and excellent roundness (0.76–0.89) for all SPNPs prepared via EHD jetting. Tentatively, blended SPNPs displayed higher circularity and lower anisotropy, as compared to single-protein SPNPs. Secondary statistical analysis indicated that blended SPNPs generally present combined features of their constituents, with some properties driven by the dominant protein constituent. Our study suggests SPNPs made from blended proteins can serve as a promising drug delivery carrier owing to the ease of production, the composition versatility, and the control over their size, shape and dispersity.
Memoria de Gestión 2020-2021
Authors:   Universidad Norbert Wiener, Rivera Lozada Oriana , Inga Berrospi Fiorella ,   Universidad Norbert Wiener, Bendezu Ccanto Jessica Yvonne ,   Universidad Norbert Wiener, Callupe Rivera Graciela Nancy ,   Universidad Norbert Wiener, Conde Carhuancho Lacey Lisbeth ,   Universidad Norbert Wiener, Aquije Choqque Nataly Yahayra ,   Universidad Norbert Wiener, Romero Reinoso Cinthia Ernestina ,   Universidad Norbert Wiener
Published: February 2022

Desde de su creación, el VRI tiene como objetivo principal fomentar la investigación en la UPNW a través de acciones y estrategias que ayuden a la formación y desarrollo de investigadores en todos los niveles de formación académica. Así, el área reúne a un grupo de profesionales y expertos de primer nivel en el área que, bajo la guía del Vicerrector de Investigación, llevaron a cabo acciones de proyección, educación y asesoramiento para estudiantes y docentes. Esto fue realizado con la finalidad de asegurar la calidad de la investigación auspiciada por la universidad. Siguiendo la visión y misión propuesta por el fundador de nuestra universidad, el VRI se propuso asegurar una experiencia educativa excepcional en la que la investigación tiene un lugar central al poner el conocimiento y los profesionales al servicio de la sociedad y del país. De este modo, actúa como bisagra entre la actividad académica y la responsabilidad social.
Perception of Values in Prospective Teachers
Authors:   Department of English Languge  Deanship of Preparatory Year, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia, Rachamalla Dr. Sana Ali , Hans Dr. Anjali ,   ELPD Trainer Cum Content Writer, Chandigarh University, Mohali, Punjab, India
Published: February 2022

Prospective teachers are those teachers who are looking towards the future. Prospective teachers are to be competent in the profession and losing belief in the profession. Prospective teachers are able to incorporate in their teaching cross-circular dimensions and themes, including environmental education. There is constant change in the society in respect to values, norms, ideals as well as attitudes of the individual which make the society more complex and integrated. Values are important because every human action is the reflection of an individual value and every human institution is the outgrowth of social values. Generally speaking, values are the norms of behavior which have been evolved during the course of time in the social, moral and spiritual fields. Values are conscious and unconscious preferences, accepted by the majority of members of the socially regulated. The purpose of this study was to explore the level of perception of values of prospective teachers of colleges of education and find out the differences, if any, in terms of gender, locality of colleges and nature of colleges in their perception of values. A sample of 40 prospective teachers was collected from different colleges located in rural and urban areas of Mohali District of Punjab state. The t-test and ANOVA test were used for analyzing the data. The prospective teachers of town are better in neighbourly values than the prospective teachers of village. The prospective teachers of village are better in perception of social values than the prospective teachers of town.
NEW METHOD FOR THE SIMULTANEOUS ESTIMATION OF SIPONIMOD AND PONESIMOD BY USING ULTRA PERFORMANCE LIQUID CHROMATOGRAPHIC SYSTEM IN ACTIVE PHARMACEUTICAL INGREDIENT FORM
Authors:   Department of Chemistry, Acharya Nagarjuna University, Guntur, India., Kethipalli Anita , Ramachandran Dittakavi ,   Department of Chemistry, Acharya Nagarjuna University, Guntur, India.
Published: February 2022

The aim of this study is to create and validate a fast, easy-to-use, affordable, sensitive, and accurate method for measuring Siponimod and Ponesimod in bulk and pharmaceutical products using Reversed-Phase Ultra-Performance Liquid Chromatography (RP-UPLC). A Luna C18 column was used with a running phase composed of 0.1% trifluoroacetic acid: acetonitrile (30:70 v/v) at a flow rate of 1.0 ml/min. UV detection was used at a wavelength of 230 nm. Ponesimod and Siponimod correlation coefficients were found to be 0.999 over a concentration range of 5-75 µg/ml and 0.5-7.5 µg/ml, respectively. Ponesimod and Siponimod have respective retention times of 1.751 and 3.203 minutes. The run time for separating Ponesimod and Siponimod peaks was 5 minutes. The validation results agreed with what's acceptable and had good limits. This method, proposed as a regular analysis and quality control tool for medications that contain these active drugs either individually or in combination, was evident to be a suitable one.
A Study of Women Empowerment with reference to Nagpur District
Authors:   Asst. Prof.Shri Niketan Arts Commerce College Reshimbag Nagpur., Pathak Mr.Vijay Janrao
Published: February 2022

There are approximately 51% female in total population of Nagpur. But if we analyze the current status of women we can realize that the scene is not even satisfactory but the worst. Women generally faced barriers to success like illiteracy, domestic violence, lack of motivation etc. For the development of the country that women should go hand by hand and shoulder to shoulder with men. Efforts are required to enhance the socio-economic status of women. It has been observed that most of the policies and programs view empowerment in the economic sense only working in the belief that economic self-reliance empowers women ignoring other variables like health, education, literacy etc. This research paper attempts to examine the efforts initiated towards empowering women. It explores the relationship between women’s empowerment, domestic violence, maternal nutritional status, and the nutritional status and growth over six months in children aged 6 to 24 months in a rural and tribal community.
Risk and Risk Factors for Postpartum Type 2 Diabetes Mellitus in Women with Gestational Diabetes: A Korean Nationwide Cohort Study
Authors: Choi Mi Jin , Choi Jimi , Chung Chae Weon
Published: February 2022

Background: There are differences in risk and risk factor findings of postpartum type 2 diabetes mellitus (T2DM) after gestational diabetes depending on study design and subjects of previous studies. This study aimed to assess these risk and risk factors more accurately through a population-based study to provide basic data for prevention strategies.Methods: This open retrospective cohort included data of 419,101 women with gestational diabetes and matched 1,228,802 control women who delivered between 2004 and 2016 from the South Korea National Health Information Database of the National Health Insurance Service. Following 14 (median 5.9) years of follow-up, the incidence and hazard ratio (HR) of postpartum T2DM were evaluated using Kaplan-Meier curves and Cox proportional regression models.Results: The incidence and HR of postpartum T2DM in women with gestational diabetes (compared to women without gestational diabetes) after the 14-year follow-up was 21.3% and 2.78 (95% confidence interval [CI], 2.74 to 2.82), respectively. Comorbid obesity (body mass index [BMI] ≥25 kg/m2) increased postpartum T2DM risk 7.59 times (95% CI, 7.33 to 7.86). Significant risk factors for postpartum T2DM were fasting glucose level, BMI, age, family history of diabetes, hypertension, and insulin use during pregnancy.Conclusion: This population-based study showed higher postpartum T2DM risk in women with gestational diabetes than in those without, which was further increased by comorbid obesity. BMI and fasting glucose level were important postpartum risk factors. The management of obesity and glycemic control may be important strategies to prevent the incidence of diabetes after delivery.
New Determinations of the Rotational Periods of 78 Vir (A2p SrCrEu) and 52 Her (A1p SiSrCr)
Authors: Monier Richard , Mary David
Published: February 2022

The TESS lightcurves of the two cool Ap stars, 78 Vir and 52 Her, are used to derive new rotational periods for both stars. A frequency analysis of the light curve of 52 Her with the Generalized Lomb–Scargle periodogram reveals a periodic structure with three harmonics. The inverse of the fundamental frequency yields a rotational period of 3.840 ± 0.037 days for 52 Her. The same analysis for 78 Vir yields two harmonics with a rotation period of 3.718 ± 0.037 days, only slightly shorter than previous determinations.
Methane-saturated Layers Limit the Observability of Impact Craters on Titan
Authors: Wakita 脇田 Shigeru 茂 , Johnson Brandon C. , Soderblom Jason M. , Shah Jahnavi , Neish Catherine D.
Published: February 2022

As the only icy satellite with a thick atmosphere and liquids on its surface, Titan represents a unique end-member to study the impact cratering process. Unlike craters on other Saturnian satellites, Titan’s craters are preferentially located in high-elevation regions near the equator. This led to the hypothesis that the presence of liquid methane in Titan’s lowlands affects crater morphology, making it difficult to identify. This is because surfaces covered by weak fluid-saturated sediment limit the topographic expression of impact craters, as sediment moves into the crater cavity shortly after formation. Here we simulate crater-forming impacts on Titan’s surface, exploring how a methane-saturated layer overlying a methane-clathrate layer affects crater formation. Our numerical results show that impacts form smaller craters in a methane-clathrate basement than a water-ice basement due to the differences in strength. We find that the addition of a methane-saturated layer atop this basement reduces crater depths and influences crater morphology. The morphology of impact craters formed in a thin methane-saturated layer is similar to that in a “dry” target, but a thick saturated layer produces an impact structure with little to no topography. A thick methane-saturated layer (thicker than 40% of the impactor diameter) could explain the dearth of craters in the low-elevation regions on Titan.
Physiological Aspects of Plasma Osmolarity and its Association with the Clinical Severity of Ischemic Stroke Evaluated with the NIHSS: A Cross-sectional Study
Authors: Siahaan Yusak Mangara Tua , Hartoyo Vinson , Muljono Michelle , Budisulistyo Trianggoro
Published: February 2022

BACKGROUND: Ischemic stroke is one of the leading causes of mortality and disability worldwide. Recent studies have observed that some physiological factors play a pivotal role in determining stroke severity, which can be assessed using the National Institutes of Health Stroke Scale (NIHSS) score. Hydration status is one of the most frequently studied physiological factors and can be evaluated by measuring plasma osmolarity levels. However, studies regarding the association between plasma osmolarity and stroke severity remain scarce.

AIM: This study aimed to investigate the association between increased blood plasma osmolarity levels and the NIHSS scores in patients with acute ischemic stroke.

METHODS: This cross-sectional study obtained medical records of subjects aged 18–80 years old who were diagnosed with their first acute ischemic stroke from January to March 2021 at the Siloam Hospitals Lippo Village Tangerang in Indonesia.

RESULTS: The NIHSS scores of patients with acute ischemic stroke were observed to have a moderate positive correlation with plasma osmolarity (p = 0.004, r = 0.309). Patients with an elevated plasma osmolarity had higher NIHSS scores than those with normal levels of plasma osmolarity (8.52 ± 5.01 vs. 6.03 ± 3.72).

CONCLUSIONS: Higher levels of plasma osmolarity among acute ischemic stroke subjects correlated positively with increased NIHSS scores on admission.
Evaluation of the Effects of One versus 4 Weeks Activation Intervals on the Rate of Orthodontic Tooth Movement: An Experimental Study
Authors: Elseidy Mahmoud , Mostafa Yehya A. , Mehanni Sammah S. , El-Sharaby Fouad A.
Published: February 2022

Objectives: To evaluate the effects of one versus four weeks reactivation of the elastomeric chain on the rate of orthodontic tooth movement (OTM) and supporting structures.
Methods: The 3rd maxillary premolars of 8 male mongrel dogs were extracted. Custom made appliance was constructed so that the 2nd premolars were allowed to slide bodily. An elastomeric chain with calibrated force of 150g was attached to the hooks of soldered tubes on the 2nd premolar’s crowns. The sample was divided into two groups based on the interval of reactivation of the elastomeric chains used for tooth movement where in group I activation was scheduled every one week versus four weeks in group II. Measurements of the amount and rate of OTM were performed every week for 12 weeks using digital caliper. The animals were then sacrificed and specimens were prepared for decalcified histological examination using Hematoxylin and Eosin stains under light microscope.
Results: No remarkable difference in the rate of OTM between the two groups was reported. The total amount of tooth movement in group I was 1.44mm ± 0.5 compared to 1.46mm ± 0.6 in group II. Histological examination revealed a more favorable tissue reaction associated with 4 weeks reactivation as regards the new formed bone, root resorption and periodontal ligament structure.
Conclusion: Altering the reactivation interval of the elastomeric chains from four to one week doesn’t have a significant impact on the rate of OTM. However, four weeks reactivation interval showed a more favorable tissue reaction associated with orthodontic tooth movement.
Treating Gnathic form of Mesial Occlusion in Early Adolescence Patients: A Clinical Trial
Authors: Hai Le , Hong Minh Nguyen Thi , Le Quỳnh Anh
Published: February 2022

AIM: The aim of the study was to evaluate the early and late results of the non-surgical orthopedic treatment efficiency in 12–14 years old children with the gnathic forms of mesial occlusion by the dentoalveolar compensation utilizing a permanent device with a palatal expanding screw.

METHODS: The study enrolled 26 patients aged 12–14 years who underwent orthopedic treatment by the dentoalveolar compensation using a permanent device with a palatal expanding screw. Late treatment results aged 4–6 years were analyzed for 21 patients by cephalometric indices, five patients were excluded from the study due to change of residence. The comparison group included 20 patients of the same age and diagnosis who received orthopedic treatment with a face mask.

RESULTS: The method of treatment utilizing a permanent apparatus with a palatal expanding screw showed better results than the facemask therapy. More pronounced changes of the general growth vector of the facial skeleton toward the maxilla normalization were noted. The anteroposterior relations between the jaw bases were normalized, the normal position of the upper and lower incisors was achieved, a stable interincisal angle was formed, and the aesthetics of the facial profile significantly improved.

CONCLUSIONS: Using a fixed apparatus with a palatal expanding screw has significantly improved patients’ morphological, physiological, and esthetic performance. The evaluation of late results (from 4 to 6 years) showed normal development of the dentistry system in 90.5% of cases that allowed avoiding surgical intervention in these patients after the end of skeletal growth.
Foot Hydrotherapy: Non-pharmacology Treatment for Reducing Anxiety in Third Trimester Pregnancy
Authors: Sudirman Jumrah , Bachri Nurjannah , Syafar Muhammad , Jusuf Elizabet Catherine , Syamsuddin Saidah , Mappaware Nasrudin Andi , Saleng Hasriani
Published: February 2022

Objective: This research aims to examine the effect of foot hydrotherapy as one of non-pharmacological therapies for reducing anxiety of pregnancy.
Method: The reported study employed Quasi Experimental method by using two Group pretest-posttest design with comparison group. It involved 57 respondents who were recruited using consecutive sampling technique. Hamilton Anxiety Rating Scale (HARS) questionnaire was used to measure the respondents’ anxiety. For bivariate analysis, the data were tested using paired samples t-test and Independent T-test
Result. The results of data analysis indicated that before the treatment, the anxiety values in the two groups were almost the same (21±2.3 dan 22.07±1.99). After the treatment in the intervention group, the anxiety value decreased while in the control group, the anxiety score was increased on the third day after the pretest measurement Data analysis which was conducted with Independent Sample t-test revealed that foot hydrotherapy using warm water reduced the anxiety level of pregnant women in the third trimester (p = 0,000).
Conclusion: Giving foot hydrotherapy is effective for reducing anxiety in pregnant women. Therefore, the non-pharmacological therapy can be socialized and applied given to the public (society), especially pregnant women
Anxiety and Depression in Patients with Breast Cancer: A Cross-sectional Study
Authors: Podvorica Elvana , Kraja Julian , Rrustemi Naser , Dugolli Xhemajl , Hyseni Ekrem
Published: February 2022

BACKROUND: The early management for distress, depression, and anxiety in breast cancer patients can help improves quality of life that adherence patients to cancer treatment. AIM: This study aimed to describe the prevalence and risk factors of anxiety and depression symptomatology of breast cancer patients in the inpatients and outpatient settings. METHODS: This study used a research and development study design. The study was conducted in at the University Clinical Center of Kosovo the Medical Oncology Clinic in Pristina from August to October 2021. The total sample in this study consisted of 50 female breast cancer patients diagnosed at least 6 months before the date of assessment, aged 18 and above, able to communicate in Albanian, signed an informed consent form, negative history of other malignancies, and absence of any temporary acute illness affecting psychological well-being while filling the questionnaire. Questionnaire used in our study is Hospital Anxiety and Depression Scale for assessing anxiety and depression in breast cancer patients. RESULTS: For anxiety score, some of them were caseness level with 82%, while 26% of study participants were in borderline, 6% in caseness, and some of them were in normal level from 68% on the depression score. The patients feel tense or wound up with 44% Mean/SD (14.67 ± 6.02), about feeling afraid that something terrible will happen and patients may have this feel Mean/SD (13 ± 1.66). Over half of them had the feeling of fear as if something awful is about to happen Mean/SD (11.33 ± 4.03) and that the feeling of fear as if they had “butterflies” in the stomach of 62% had the feeling sometimes, beautiful often, and very often Mean/SD (10.33 ± 4.92). CONCLUSION: The results indicate that it is very important to measure the level of anxiety and depression in women with breast cancer, which are two common mental disorders in breast cancer.
Critical Care Problem in a Case of Intracerebral Hemorrhage Due to Eclampsia and Its Ethics and Medicolegal Consideration
Authors: Kulsum Kulsum , Suryadi Taufik
Published: February 2022

BACKGROUND: Eclampsia accompanied by hemolysis elevated liver enzymes low platelet (HELLP) syndrome is an emergency condition during late trimester pregnancy characterized by hypertension, seizures, and coma. Obstetric history is known that the patient does not conducted antenatal care regularly to the doctor so that the patient does not know she has eclampsia. One of which complications due to eclampsia is intracerebral hemorrhage which is a major cause of death and morbidity in pregnant woman. This case report discusses how ethical and medicolegal decision-making for procedures to withholding or withdrawing life support for the critical care problem. The ethical dilemma faced by neuroanesthesia and critical care (NACC) consultants is whether to continue to treat patients in the intensive care unit (ICU) even though the results will be in vain or to restrict critical care because they concluded that the condition of the patient has a terminal stage.

CASE REPORT: A reported case of a 23-year-old woman, pregnant, and had a caesarian section for the indication of eclampsia accompanied by HELLP syndrome in rural hospital. Because the patient’s condition worsened, she was referred to Zainoel Abidin hospital due to decrease in consciousness and a computed tomography scan of the head showed extensive bleeding. The results of the neuroanesthesia and neurosurgery team’s assessment stated that there was no indication of surgery on the patient because extensive bleeding had occurred accompanied by brain edema. The patient then undergoes treatment in the ICU to improve the patient’s critical condition. In an effort to overcome this problem, the NACC consultant consults with an ethics and medicolegal consultant as a representation of the medical committee and ethical committee to determine the withholding or withdrawing of life support therapy to the patient.

CONCLUSION: Life support therapies that can be withhold or withdraw are simply an extraordinary treatment that provides no benefit. The basic principles of ethics in making decisions to do withholding and withdrawing life support in these patients are beneficence and non-maleficence, while the medicolegal principle in these patients lies in the patient’s condition being medically incurable (terminal state) and medical treatment is useless (futile treatment).
The Effectiveness of the Real-case Online-based Learning on Nursing Care Plan Self-efficacy
Authors: Wantonoro Wantonoro , Anita Diyah , Mamnuah Mamnuah , Nguyen Tuan Van
Published: February 2022

BACKGROUND: Online learning has become a new thing that is adapted and supports the learning process, including in nursing education during the COVID-19 pandemic. However, various studies report that there are limitations to conduct the online learning. AIM: The objective of the study was to identify the effectiveness of the real-case online-based learning in understanding the nursing care plan process and, self-efficacy from the students’ perspective. METHODS: Mix methods; explanatory sequential designs. One-hundred and fifty-seven respondents participated in the quantitative approach (64 students in the intervention group and, 93 students in the control group). Six students among the quantitative approach were participated in the qualitative approach. Mann-Whitney’s statistical approach was used for the quantitative approach, while Colaizzi’s method of data analysis was used for the qualitative approach. RESULTS: There was no significant difference between the control and treatment groups in the nursing care plan (p = 0.13) and student self-efficacy (p = 0.45). In addition, there were five themes identified by the students’ perspectives regarding the real case online learning, including; 1) opinions on learning, 2) the feelings experienced during the learning, 3) learning benefits, 4) learning barriers, and 5) expectations of learning. CONCLUSION: The real case online learning provides a different atmosphere including more interesting class, interactive interaction with the patients directly and providing positive experience for the students in the form of seeing the real cases online. The infrastructure/facilities (internet availability and stability) are important factors in the online learning process. The real case online learning is recommended as an alternative of learning that is more interesting and interactive involving the patients, students, and direct supervisors. Further research on the learning process of nursing care with a mixed system; limited offline and online cases with real, comprehensive, and interdisciplinary approaches are recommended.
Clinical Forensic Evidence in Gunshot Wounds through Anesthesia and Surgical Procedures: A Case Report
Authors: Suryadi Taufik , Kulsum Kulsum , Simatupang Ari Putra , Rahmatillah Irhamni , Mentari Putri , Fathima Raisha
Published: February 2022

BACKGROUND: Clinical forensic evidence of live victims with gunshot wounds can be supported by anesthesia and surgical procedures. Gunshot wounds are a complex and traumatic type of wound that are commonly found in forensic practice, most of which can cause death. Injuries to gunshot wounds are caused by the penetration of a projectile into the body that is ejected from the barrel of a gun due to the burning of gunpowder from the bullet. Using anesthetic procedures and thoracic surgery can help prove the victim's gunshot wound. Medical evidence in the form of bullet projectiles found on the victim's body can be used as legal evidence. So it can be said that anesthesia and thoracic surgery procedures can be one of the modalities of clinical forensic examination in proving the existence of a criminal event.   CASE REPORT: The method of this study was a case report. A 58-year-old male victim was shot in the left back. Forensic examination of the victim showed a gunshot wound to the left side of the back about the 11th thoracic vertebra, round or oval in shape, accompanied by seams of abrasions around the wound, no seams of tattoos, soot or fire were found and not accompanied by a gunshot wound. Based on the results of the radiographic examination of the posteroanterior and lateral chest radiographs, two cylindrical radio-opaque images were found in the left hemithorax. During anesthesia and thoracic surgery, a foreign body was found in the left thoracic wall region, as well as lacerations in the left inferior lobe of the lung. Clinical forensic evidence in gunshot wounds has been successfully carried out using anesthesia and surgical procedures. The evidence was also reviewed from the radiological examination which proved the existence of bullet projectiles by virtual imaging.   CONCLUSION: Clinical forensic evidence of course continues to evolve in accordance with advances in medical technology. The better the proof method, the easier it is to find the desired evidence. Anesthesia and surgical procedures can be used as an alternative to forensic evidence in clinical cases.
Gastrointestinal Endoscopy and Coronavirus Disease-2019 Pandemic
Authors: Darmadi Darmadi , Pakpahan Cennikon , Ruslie Riska Habriel
Published: February 2022

Coronavirus disease-2019 (COVID-19) is a disease caused by severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2). It has become a pandemic since March 11, 2020. It carries a significant burden and hampers gastrointestinal endoscopy practice. Since SARS-CoV-2 receptors are found in the gastrointestinal tract, COVID-19 also manifests as gastrointestinal symptoms. The viable virus is also detected in stool, carrying a high risk of transmission. Therefore, gastrointestinal endoscopy practice needs to be changed to prevent spreading from patients and medical personnel. All patients should be screened for the possibility of infection. Triage is done to determine the urgency of cases. Elective cases are postponed while semi-urgent and urgent cases are treated accordingly. A level 2 personal protective equipment (PPE) should be used for negative/suspected COVID-19 and a level 3 PPE is used for the confirmed case. Endoscopy unit should have negative-pressure room or proper ventilation, separated unit between negative/suspected and confirmed cases, exclusive equipment for COVID-19 case, and proper disinfection of equipment and room. Medical personnel must be screened regularly and positive information regarding gastrointestinal endoscopy practice should be spread to patients.
Pinctada Maxima Pearl Shells as a Promising Bone Graft Material in the World of Dentistry
Authors: Chandha M. Hendra , Mappangara Surijana , Achmad Harun , Oktawati Sri , Ramadhan Sitti Raoda Juanita , Yudin Muhammad , Asri Gustivanny Dwipa
Published: February 2022

BACKGROUND: Pinctada maxima pearl shell contains inorganic and organic materials that have a bone-like basic structure that facilitates bone remodeling.

AIM: This study aimed to describe the effectiveness of Pinctada maxima pearl shells as bone graft material in the world of dentistry using an animal model.

METHODS: Research uses Pinctada maxima pearl shell that was processed into hydroxyapatite Pinctada maxima (HPM) powder. Chemical and surface characteristics of HPM were performed with X-ray fluorescence (XRF), Fourier transform infra-red (FTIR), and X-ray diffraction (XRD), respectively. Thirty male guinea pigs were randomly assigned into three groups: Negative control (NC), positive control, and HPM. After 14–21 days of observation, guinea pigs were sacrificed. Bone formation was seen through immunohistochemical examination of osteoprotegerin (OPG) and bone morphogenetic protein (BMP2) expression. Data were analyzed through Shapiro wills and analysis of variance with a significance level of 5%.

RESULTS: There was a high expression of OPG and BMP2 on days 14–21 in the HPM group when compared to the NC group with a significance level of 5%.

CONCLUSION: HPM powder can be used as a promising bone graft material in the world of dentistry.
A new species of Mindomys (Rodentia, Cricetidae) with remarks on external traits as indicators of arboreality in sigmodontine rodents
Authors: Brito Jorge , Koch Claudia , Tinoco Nicolás , Pardiñas Ulyses F. J.
Published: February 2022

The diversity of the oryzomyine rat Mindomys (Cricetidae, Sigmodontinae, Oryzomyini), is doubled here with the description of a new species from the remote Cordillera de Kutukú (Ecuador). The novel form can be easily differentiated from Mindomys hammondi –type species of the genus– by a large set of anatomical traits including, among others, larger jugals, parietal “wings” extending to zygomatic roots, larger otic capsules, well-exposed petrosals, narrow zygomatic plates almost without upper free borders, foramen magnum caudally oriented, larger molars, and accessory root of first upper molar present. Until now, the records of Mindomys were restricted to western Andean foothills. The material from Kutukú highlights an Amazonian species and reinforces the valuable biological significance of isolated mountain ranges in eastern Ecuador. Since Mindomys shows some external traits classically related to arboreal life, here we present a brief reappraisal of this poorly explored topic. A partially neglected anatomical system in sigmodontine studies, the fore feet, encloses crucial information reflecting arboreality.
Nicotiana gandarela (Solanaceae), a new species of ‘tobacco’ highly endangered from the Quadrilátero Ferrífero in Brazil
Authors: Augsten Mariana , Meyer Pablo Burkowski , Freitas Loreta B. , Batista João A. N. , Stehmann João Renato
Published: February 2022

Nicotiana gandarela Augsten & Stehmann (Solanaceae), sp. nov., a small ’tobacco’ known only from one locality at Serra do Gandarela, in the state of Minas Gerais, Brazil, is described and illustrated. It is morphologically characterized by its rosulate basal leaves, red corolla with a short tube not inflated at the apex, and the peculiar habitat, a shaded site under a rocky outcrop ledge along a forested stream. Phylogenetic analyses based on a combined dataset of nuclear (ITS) and plastid (ndhF, trnLF, and trnSG) DNA sequences revealed that the species belongs to the Nicotiana sect. Alatae and is sister to the clade with the remaining species in the section. A key for the identification of Brazilian species of the section is given. The unusual habitat, the small population size, and the intense pressure of mining activities in the surroundings made the species assessed as Critically Endangered (CR), needing conservation efforts to avoid its extinction.
Du nourrisson tube digestif au bébé superman
Authors: Golse Bernard
Published: February 2022

Après avoir rappelé l’histoire des idées qui a mené d’une vision très réductrice du nourrisson au bébé en tant que personne en devenir, l’auteur rappelle les différents types d’interactions dans lesquelles le bébé est d’emblée activement engagé. Certaines compétences du bébé ne sont que potentielles telle la motricité libérée qui ne s’extériorise que dans certaines circonstances particulières. Il est encore difficile de préciser quel est le rôle de ces compétences en réserve. Quoi qu’il en soit, le bébé n’est pas un super-héros, dont la représentation ne peut servir que le narcissisme des adultes. La néoténie et le pari piklérien sont enfin évoqués pour faire sentir que si héroïsme du bébé il y a, celui-ci concerne son extraordinaire capacité à mettre en œuvre sa petite part active dans un environnement approprié.
Thésée et le Minotaure : un groupe Mythes en Sessad
Authors: Baurin Isabelle , Tarhan Yeliz
Published: February 2022

Une équipe réfléchit à un dispositif de groupe thérapeutique dans un Sessad (service d’éducation spécialisée et de soin à domicile) accueillant des adolescents. Le mythe choisi, Thésée et le Minotaure, peut en soi constituer une métaphore de la traversée adolescente tant les thématiques qu’il recèle en sont proches (distanciation et émancipation des parents, rencontre amoureuse, passivation du groupe de jeunes gens…). Par le dispositif inspiré de P. Lafforgue, les adolescents cheminent, séance après séance, explorent ces thèmes et finissent, pour certains, par en faire quelque chose pour eux-mêmes, comme Thésée qui devient adulte à la fin de son épopée.
Mineurs incarcérés
Authors: Varnoux Aurélien , Monod Guillaume
Published: February 2022

Les soins pédopsychiatriques se déploient en détention avec des moyens insuffisants. La politique pénale des mineurs soutient les réponses éducatives avant tout, mais on dénombre environ huit cents mineurs incarcérés en France. Il ne sera pas dit que le travail éducatif n’est pas possible en détention ni que le travail psychothérapique sous contrainte soit une incohérence ! La pédopsychiatrie en milieu carcéral ne donne pas à voir une clinique singulière, mais permet de recevoir des mineurs difficiles à rencontrer en consultation ambulatoire. Des approches originales doivent être consolidées pour répondre à l’expression comportementale et corporelle de la souffrance psychique de ces mineurs. Enfin, la coordination des interventions est un point de vigilance majeur.
L’approche transculturelle dans les mesures judiciaires d’investigation
Authors: Merschardt Marie-Noëlle
Published: February 2022

Lorsque des contextes familiaux et/ou environnementaux compromettent la sécurité psychique et physique des enfants, le juge des enfants peut ordonner une Mesure Judiciaire d’Investigation Éducative (MJIE) afin d’évaluer le danger encouru par l’enfant. Cet article porte sur le contexte des MJIE pour des enfants dont les parents viennent d’ailleurs. Après la présentation de la MJIE, les limites institutionnelles rencontrées, nous questionnons l’évaluation du danger dans ces situations, dans leur spécificité. L’objectif est d’ajuster notre pratique et de proposer des outils permettant de tenir compte de la dimension culturelle dans la rencontre, l’évaluation et l’analyse de la situation du danger des enfants de migrants.