bluuebunny/crossref_metadata_2025 huggingface dataset:
Pruritus: A Sensory Symptom Generated in Cutaneous Immuno-Neuronal Crosstalk
Authors: Szöllősi Attila Gábor , Oláh Attila , Lisztes Erika , Griger Zoltán , Tóth Balázs István
Published: March 2022

Pruritus or itch generated in the skin is one of the most widespread symptoms associated with various dermatological and systemic (immunological) conditions. Although many details about the molecular mechanisms of the development of both acute and chronic itch were uncovered in the last 2 decades, our understanding is still incomplete and the clinical management of pruritic conditions is one of the biggest challenges in daily dermatological practice. Recent research revealed molecular interactions between pruriceptive sensory neurons and surrounding cutaneous cell types including keratinocytes, as well as resident and transient cells of innate and adaptive immunity. Especially in inflammatory conditions, these cutaneous cells can produce various mediators, which can contribute to the excitation of pruriceptive sensory fibers resulting in itch sensation. There also exists significant communication in the opposite direction: sensory neurons can release mediators that maintain an inflamed, pruritic tissue-environment. In this review, we summarize the current knowledge about the sensory transduction of pruritus detailing the local intercellular interactions that generate itch. We especially emphasize the role of various pruritic mediators in the bidirectional crosstalk between cutaneous non-neuronal cells and sensory fibers. We also list various dermatoses and immunological conditions associated with itch, and discuss the potential immune-neuronal interactions promoting the development of pruritus in the particular diseases. These data may unveil putative new targets for antipruritic pharmacological interventions.
Risk Scoring System for Vancomycin-Associated Acute Kidney Injury
Authors: Kim Jee Yun , Kim Kyun Young , Yee Jeong , Gwak Hye Sun
Published: March 2022

Vancomycin-associated acute kidney injury (AKI) remains a major challenge for patients and clinicians. This study aimed to construct a risk scoring system for vancomycin-associated AKI. We retrospectively reviewed medical records of patients who underwent therapeutic drug monitoring for vancomycin from June 2018 to July 2019. We selected possible risk factors for AKI by univariate and multivariable logistic regression analyses and developed a scoring system for vancomycin-associated AKI. Machine learning methods were utilized to predict risk factors for the occurrence of AKI. The incidence of vancomycin-associated AKI was 31.7% among 104 patients included in this study. A bodyweight ≤60 kg (two points), a Charlson comorbidity index ≥3 (two points), a vancomycin trough serum level >15 μg/ml (one point), and concomitant use of ≥6 nephrotoxic agents (two points) were included to construct a risk scoring system based on the coefficient from the logistic regression model. The area under the receiver operating characteristic curve (AUROC) (mean, 95% confidence interval (CI)) across 10 random iterations using five-fold cross-validated multivariate logistic regression, elastic net, random forest, support vector machine (SVM)-linear kernel, and SVM-radial kernel models was 0.735 (0.638–0.833), 0.737 (0.638–0.835), 0.721 (0.610–0.833), 0.739 (0.648–0.829), and 0.733 (0.640–0.826), respectively. For total scores of 0–1, 2–3, 4–5, 6–7, the risk of vancomycin-associated AKI was 5, 25, 45, and 65%, respectively. Our scoring system can be applied to clinical settings in which several nephrotoxic agents are used along with vancomycin therapy.
ALG-bFGF Hydrogel Inhibiting Autophagy Contributes to Protection of Blood–Spinal Cord Barrier Integrity via PI3K/Akt/FOXO1/KLF4 Pathway After SCI
Authors: Zhang Renkan , Xie Ling , Wu Fangfang , Xu Ji , Lu Leilei , Cao Lin , Li Lei , Meng Weiyang , Zhang Hongyu , Shao Chuxiao , Li Xiaokun , Chen Daqing
Published: March 2022

Promoting blood–spinal cord barrier (BSCB) repair at the early stage plays a crucial role in treatment of spinal cord injury (SCI). Excessive activation of autophagy can prevent recovery of BSCB after SCI. Basic fibroblast growth factor (bFGF) has been shown to promote BSCB repair and locomotor function recovery in SCI. However, the therapeutic effect of bFGF via direct administration on SCI is limited because of its rapid degradation and dilution at injury site. Based on these considerations, controlled release of bFGF in the lesion area is becoming an attractive strategy for SCI repair. At present, we have designed a sustained-release system of bFGF (called ALG-bFGF) using sodium alginate hydrogel, which is able to load large amounts of bFGF and suitable for in situ administration of bFGF in vivo. Here, traumatic SCI mice models and oxygen glucose deprivation (OGD)–stimulated human brain microvascular endothelial cells were performed to explore the effects and the underlying mechanisms of ALG-bFGF in promoting SCI repair. After a single in situ injection of ALG-bFGF hydrogel into the injured spinal cord, sustained release of bFGF from ALG hydrogel distinctly prevented BSCB destruction and improved motor functional recovery in mice after SCI, which showed better therapeutic effect than those in mice treated with bFGF solution or ALG. Evidences have demonstrated that autophagy is involved in maintaining BSCB integrity and functional restoration in animals after SCI. In this study, SCI/OGD exposure–induced significant upregulations of autophagy activation-related proteins (Beclin1, ATG5, LC3II/I) were distinctly decreased by ALG-bFGF hydrogel near the baseline and not less than it both in vivo and in vitro, and this inhibitory effect contributed to prevent BSCB destruction. Finally, PI3K inhibitor LY294002 and KLF4 inhibitor NSC-664704 were applied to further explore the underlying mechanism by which ALG-bFGF attenuated autophagy activation to alleviate BSCB destruction after SCI. The results further indicated that ALG-bFGF hydrogel maintaining BSCB integrity by inhibiting autophagy activation was regulated by PI3K/Akt/FOXO1/KLF4 pathway. In summary, our current study revealed a novel mechanism by which ALG-bFGF hydrogel improves BSCB and motor function recovery after SCI, providing an effective therapeutic strategy for SCI repair.
Advances and Potentials of Polydopamine Nanosystem in Photothermal-Based Antibacterial Infection Therapies
Authors: Fan Shuhao , Lin Wensen , Huang Yifan , Xia Jiaojiao , Xu Jun-Fa , Zhang Junai , Pi Jiang
Published: March 2022

Bacterial infection remains one of the most dangerous threats to human health due to the increasing cases of bacterial resistance, which is caused by the extensive use of current antibiotics. Photothermal therapy (PTT) is similar to photodynamic therapy (PDT), but PTT can generate heat energy under the excitation of light of specific wavelength, resulting in overheating and damage to target cells or sites. Polydopamine (PDA) has been proved to show plenty of advantages, such as simple preparation, good photothermal conversion effects, high biocompatibility, and easy functionalization and adhesion. Taking these advantages, dopamine is widely used to synthesize the PDA nanosystem with excellent photothermal effects, good biocompatibility, and high drug loading ability, which therefore play more and more important roles for anticancer and antibacterial treatment. PDA nanosystem-mediated PTT has been reported to induce significant tumor inhibition, as well as bacterial killings due to PTT-induced hyperthermia. Moreover, combined with other cancer or bacterial inhibition strategies, PDA nanosystem-mediated PTT can achieve more effective tumor and bacterial inhibitions. In this review, we summarized the progress of preparation methods for the PDA nanosystem, followed by advances of their biological functions and mechanisms for PTT uses, especially in the field of antibacterial treatments. We also provided advances on how to combine PDA nanosystem-mediated PTT with other antibacterial methods for synergistic bacterial killings. Moreover, we further provide some prospects of PDA nanosystem-mediated PTT against intracellular bacteria, which might be helpful to facilitate their future research progress for antibacterial therapy.
A Comprehensive Evaluation of Sdox, a Promising H2S-Releasing Doxorubicin for the Treatment of Chemoresistant Tumors
Authors: Alov Petko , Al Sharif Merilin , Aluani Denitsa , Chegaev Konstantin , Dinic Jelena , Divac Rankov Aleksandra , Fernandes Miguel X. , Fusi Fabio , García-Sosa Alfonso T. , Juvonen Risto , Kondeva-Burdina Magdalena , Padrón José M. , Pajeva Ilza , Pencheva Tania , Puerta Adrián , Raunio Hannu , Riganti Chiara , Tsakovska Ivanka , Tzankova Virginia , Yordanov Yordan , Saponara Simona
Published: March 2022

Sdox is a hydrogen sulfide (H2S)-releasing doxorubicin effective in P-glycoprotein-overexpressing/doxorubicin-resistant tumor models and not cytotoxic, as the parental drug, in H9c2 cardiomyocytes. The aim of this study was the assessment of Sdox drug-like features and its absorption, distribution, metabolism, and excretion (ADME)/toxicity properties, by a multi- and transdisciplinary in silico, in vitro, and in vivo approach. Doxorubicin was used as the reference compound. The in silico profiling suggested that Sdox possesses higher lipophilicity and lower solubility compared to doxorubicin, and the off-targets prediction revealed relevant differences between Dox and Sdox towards several cancer targets, suggesting different toxicological profiles. In vitro data showed that Sdox is a substrate with lower affinity for P-glycoprotein, less hepatotoxic, and causes less oxidative damage than doxorubicin. Both anthracyclines inhibited CYP3A4, but not hERG currents. Unlike doxorubicin, the percentage of zebrafish live embryos at 72 hpf was not affected by Sdox treatment. In conclusion, these findings demonstrate that Sdox displays a more favorable drug-like ADME/toxicity profile than doxorubicin, different selectivity towards cancer targets, along with a greater preclinical efficacy in resistant tumors. Therefore, Sdox represents a prototype of innovative anthracyclines, worthy of further investigations in clinical settings.
Prior Cardiovascular Treatments—A Key Characteristic in Determining Medication Adherence After an Acute Myocardial Infarction
Authors: Campain Anna , Hockham Carinna , Sukkar Louisa , Rogers Kris , Chow Clara K , Lung Thomas , Jun Min , Pollock Carol , Cass Alan , Sullivan David , Comino Elizabeth , Peiris David , Jardine Meg
Published: March 2022

Objective: To investigate long-term adherence to guideline-recommended cardioprotective medications following hospitalization for an acute myocardial infarction (AMI), and identify characteristics associated with adherence.

Methods: An Australian population-based cohort study was used to identify participants who had their first AMI between 2006 and 2014 and were alive after 12 months. Linked routinely collected hospital, and prescription medication claims data was used to study adherence over time. Predictors and rates of adherence to both lipid-lowering medication and renin-angiotensin system blockade at 12 months post-AMI was assessed.

Results: 14,200 people (mean age 69.9 years, 38.7% female) were included in our analysis. At 12 months post-AMI, 29.5% (95% CI: 28.8–30.3%) of people were adherent to both classes of medication. Individuals receiving treatment with both lipid-lowering medication and renin-angiotensin system blockade during the 6 months prior to their AMI were over 9 times more likely to be adherent to both medications at 12 months post-AMI (66.2% 95% CI: 64.8–67.5%) compared to those with no prior medication use (treatment naïve) (7.1%, 95% CI: 6.4–7.9%). Prior cardiovascular treatment was the strongest predictor of long-term adherence even after adjusting for age, sex, education and income.

Conclusions: Despite efforts to improve long-term medication adherence in patients who have experienced an acute coronary event, considerable gaps remain. Of particular concern are people who are commencing guideline-recommended cardioprotective medication at the time of their AMI. The relationship between prior cardiovascular treatments and post AMI adherence offers insight into the support needs for the patient. Health care intervention strategies, strengthened by enabling policies, are needed to provide support to patients through the initial months following their AMI.
Pyroptosis-Related Inflammasome Pathway: A New Therapeutic Target for Diabetic Cardiomyopathy
Authors: Cai Zhengyao , Yuan Suxin , Luan Xingzhao , Feng Jian , Deng Li , Zuo Yumei , Li Jiafu
Published: March 2022

Pyroptosis is a highly specific type of inflammatory programmed cell death that is mediated by Gasdermine (GSDM). It is characterized by inflammasome activation, caspase activation, and cell membrane pore formation. Diabetic cardiomyopathy (DCM) is one of the leading diabetic complications and is a critical cause of fatalities in chronic diabetic patients, it is defined as a clinical condition of abnormal myocardial structure and performance in diabetic patients without other cardiac risk factors, such as hypertension, significant valvular disease, etc. There are no specific drugs in treating DCM despite decades of basic and clinical investigations. Although the relationship between DCM and pyroptosis is not well established yet, current studies provided the impetus for us to clarify the significance of pyroptosis in DCM. In this review, we summarize the recent literature addressing the role of pyroptosis and the inflammasome in the development of DCM and summary the potential use of approaches targeting this pathway which may be future anti-DCM strategies.
Construction of the Social Network Information Dissemination Index System Based on CNNs
Authors: Han Weihong , Xiao Linhe , Wu Xiaobo , He Daihai , Wang Zhen , Li Shudong
Published: March 2022

The information dissemination index system is an effective way to measure the dissemination of public opinion events in social networks. Due to the complexity, variability, and asymmetry of information, the construction of traditional information dissemination index systems demands excessive reliance on manual intervention, has large deviations, and is applied in a limited range. Such shortcomings cannot meet the requirements of constructing an objective, comprehensive, and highly credible index system. Therefore, we propose a method of constructing a multilevel and multigranular information dissemination index system with complex perspectives. In addition, we use the deep learning method of the convolutional neural network to extract the rich convolution features of public opinion events in the information dissemination process. Then, we train the weight, and it forms the corresponding weight of the information dissemination index systems. The experimental results prove that the method we use is superior to other methods and has better performance on the data set of a specific field.
Short- to Intermediate-Range Structure, Transport, and Thermophysical Properties of LiF–NaF–ZrF4 Molten Salts
Authors: Chahal Rajni , Banerjee Shubhojit , Lam Stephen T.
Published: March 2022

LiF–NaF–ZrF4 multicomponent molten salts are identified as promising candidates for coolant salts in molten salt reactors and advanced high-temperature reactors. This study focused on low-melting point salt compositions of interest: 38LiF–51NaF–11ZrF4, 42LiF–29NaF–29ZrF4, and 26LiF–37NaF–37ZrF4. Ab-initio molecular dynamics (AIMD) calculations were performed and compared with available experimental data to assess the ability of rigid ion models (RIM) to reproduce short- to intermediate-range structure, transport, and thermophysical properties of the LiF–NaF–ZrF4 salt mixtures. It is found that as ZrF4 mol% increases, the average cation–anion coordination number (CN) of monovalent cations (Li+, Na+) obtained from RIM calculations decreases, while multivalent Zr4+ CN varied from 15% to 19% in comparison to corresponding AIMD values. In addition, RIM is found to predict the existence of 7, 8, and 9 coordinated fluorozirconate complexes, while AIMD and the available experimental data showed an occurrence of 6, 7, and 8 coordinated complexes in the melt. The intermediate-range structure analysis revealed that while the RIM parameters are able to reproduce a local structure for lower ZrF4 mol% salts such as in 38LiF–51NaF–11ZrF4, an extensive fluorozirconate network formation is observed in RIM simulations for higher ZrF4 mol% compositions. The network generated by RIM parameters is found to be mainly connected by “corner-sharing” fluorozirconate complexes as opposed to both “edge-sharing” and “corner-sharing” connectively portrayed by AIMD. It is found that a close agreement between AIMD and the RIM salt structure for the 11-mol% ZrF4 salt resulted in good agreement in the calculated Zr diffusivities and the viscosity values. However, due to the inaccurate short- to intermediate-range structure prediction by RIM for higher ZrF4 mol% compositions, thermophysical properties such as densities and heat capacity differ by up to 26% and 27%, respectively, upon comparison with AIMD and experimental values. Also, the network-dominated properties such as diffusion coefficients and viscosities differed by up to two and three orders of magnitude, respectively. This study signifies the importance of accurate salt structure generation for an accurate prediction of transport and thermophysical properties of multicomponent molten salts.
Molecular Polar Surface Area, Total Solvent Accessible Surface Area (SASA), Heat of Formation, and Gamma-Ray Attenuation Properties of Some Flavonoids
Authors: Tekin Huseyin Ozan , ALMisned Ghada , Issa Shams A. M. , Kasikci Emel Serdaroglu , Arooj Mahreen , Ene Antoaneta , Al-Buriahi M. S. , Konuk Muhsin , Zakaly Hesham M. H.
Published: March 2022

The chemical and physical characteristics of several flavonoid compounds such as geraniol, thymoquinone, betaine, apigenin, N-acetylcysteine, catechin, l-carnosine, epigallocatachin, and saponarin were examined in this work. Numerous molecular properties of all flavonoid compounds used in this study were calculated using the Calculate Molecular Properties module of Accelrys Discovery Studio v20.1.0.19295.0. These properties included molecular polar surface area, total solvent accessible surface area, and heat of formation. We used the MCNPX general-purpose Monte Carlo code in combination with the Phy-X PSD software to determine gamma-ray interaction parameters such as attenuation coefficients, effective atomic numbers, and buildup factors. The findings indicate that the flavonoids’ elemental compositions have a direct effect on their chemical and physical properties. Additionally, a synergistic interaction of chemical and physical behaviors has been observed. Among the flavonoids studied, saporanin was shown to have the highest polar surface area and solvent accessible surface area, as well as the highest stability. Additionally, saporanin had the strongest gamma-ray attenuation characteristics across a broad photon energy range. It may be inferred that saporanin’s elemental structure enables a synergistic relationship between its chemical and physical characteristics. The findings of this study may contribute to the evaluation of saporanin’s hypoglycemic, antibacterial, and hepatoprotective effects.
Transparent Colloidal Crystals With Structural Colours
Authors: Erdem Talha , O’Neill Thomas , Zupkauskas Mykolas , Caciagli Alessio , Xu Peicheng , Lan Yang , Bösecke Peter , Eiser Erika
Published: March 2022

Spatially ordered arrangements of spherical colloids are known to exhibit structural colours. The intensity and brilliance of these structural colours typically improve with colloidal monodispersity, low concentrations of point and line defects and with increasing refractive index contrast between the colloids and the embedding medium. Here we show that suspensions of charge stabilised, fluorinated latex particles with low refractive-index contrast to their aqueous background form Wigner crystals with FCC symmetry for volume fractions between 13 and 40%. In reflection they exhibit both strong, almost angle-independent structural colours and sharp, more brilliant Bragg peaks despite the particle polydispersity and bimodal distribution. Simultaneously, these suspensions appear transparent in transmission. Furthermore, binary AB, A2B and A13B type mixtures of these fluorinated and similarly sized polystyrene particles appeared predominantly white but with clear Bragg peaks indicating a CsCl-like BCC structure and more complex crystals. We characterised the suspensions using a combination of reflectivity measurements and small-angle x-ray scattering, complemented by reflectivity modelling.
Multidimensional Self-Propelled Motion Based on Nonlinear Science
Authors: Fujita Risa , Matsuo Muneyuki , Nakata Satoshi
Published: March 2022

Self-propelled objects, which exhibit characteristic features of motion, are proposed based on nonlinear science. At first, a self-propelled object with length like undulatory swimming is designed, i.e., the phase of oscillation at several points on the object is propagated in the opposite direction of motion. Second, the vertical oscillation of a camphor disk is created at an amphiphilic molecular layer developed on water. The proposed systems suggest that nonlinearity can enhance the autonomy of self-propelled objects as multidimensional motion.
Recent Progress in Nonlinear Frequency Conversion of Optical Vortex Lasers
Authors: Liu Jie , Duan Yanmin , Li Zhihong , Zhang Ge , Zhu Haiyong
Published: March 2022

Optical vortices are optical fields that possess a helical phase and orbital angular momentum, which have found the application in micromanipulation, optical communication, orbital angular momentum entanglement, super-resolution imaging, metrology, etc. The urgent need for the wide spreading applications of vortex lasers is to increase the wavelength versatility. In this study, the nonlinear frequency conversion of vortex lasers with a focus on sum frequency generation stimulated Raman scattering, and optical parametric oscillators were meticulously reviewed. The characteristics of the topological charge transfer and output beam profiles of different frequency conversion were discussed. As the precise tuning of optical fields in both temporal and spatial domains shall be the trend of future studies, it is our hope that this review shall serve as a reference for future research. Combining these techniques with the streaming methods to produce optical vortices, i.e., annular pump, off-axis pump, reflection mirror with defect spots, spherical aberration, and birefringence, it is advisable to expand the wavelength and fill the wavelength gap in the ultraviolet, visible, and infrared bands.
Biomechanical Correlates of Falls Risk in Gait Impaired Stroke Survivors
Authors: Nagano Hanatsu , Said Catherine M. , James Lisa , Sparrow William A. , Begg Rezaul
Published: March 2022

Increased falls risk is prevalent among stroke survivors with gait impairments. Tripping is the leading cause of falls and it is highly associated with mid-swing Minimum Foot Clearance (MFC), when the foot’s vertical margin from the walking surface is minimal. The current study investigated MFC characteristics of post-stroke individuals (n = 40) and healthy senior controls (n = 21) during preferred speed treadmill walking, using an Optotrak 3D motion capture system to record foot-ground clearance. In addition to MFC, bi-lateral spatio-temporal gait parameters, including step length, step width and double support time, were obtained for the post-stroke group’s Unaffected and Affected limb and the control group’s Dominant and Non-dominant limbs. Statistical analysis of MFC included central tendency (mean, median), step-to-step variability (standard deviation and interquartile range) and distribution (skewness and kurtosis). In addition, the first percentile, that is the lowest 1% of MFC values (MFC 1%) were computed to identify very high-risk foot trajectory control. Spatio-temporal parameters were described using the mean and standard deviation with a 2 × 2 (Group × Limb) Multivariate Analysis of Variance applied to determine significant Group and Limb effects. Pearson’s correlations were used to reveal any interdependence between gait variables and MFC control. The main finding of the current research was that post-stroke group’s affected limb demonstrated lower MFC 1% with higher variability and lower kurtosis. Post-stroke gait was also characterised by shorter step length, larger step width and increased double support time. Gait retraining methods, such as using real-time biofeedback, would, therefore, be recommended for post-stroke individuals, allowing them to acquire optimum swing foot control and reduce their tripping risk by elevating the swing foot and improving step-to-step consistency in gait control.
The Influence of Modifiable Factors on Breast and Prostate Cancer Risk and Disease Progression
Authors: Tan Keely , Naylor Matthew J.
Published: March 2022

Breast and prostate cancers are among the most commonly diagnosed cancers worldwide, and together represented almost 20% of all new cancer diagnoses in 2020. For both cancers, the primary treatment options are surgical resection and sex hormone deprivation therapy, highlighting the initial dependence of these malignancies on the activity of both endogenous and exogenous hormones. Cancer cell phenotype and patient prognosis is not only determined by the collection of specific gene mutations, but through the interaction and influence of a wide range of different local and systemic components. While genetic risk factors that contribute to the development of these cancers are well understood, increasing epidemiological evidence link modifiable lifestyle factors such as physical exercise, diet and weight management, to drivers of disease progression such as inflammation, transcriptional activity, and altered biochemical signaling pathways. As a result of this significant impact, it is estimated that up to 50% of cancer cases in developed countries could be prevented with changes to lifestyle and environmental factors. While epidemiological studies of modifiable risk factors and research of the biological mechanisms exist mostly independently, this review will discuss how advances in our understanding of the metabolic, protein and transcriptional pathways altered by modifiable lifestyle factors impact cancer cell physiology to influence breast and prostate cancer risk and prognosis.
Pastures and Climate Extremes: Impacts of Cool Season Warming and Drought on the Productivity of Key Pasture Species in a Field Experiment
Authors: Churchill Amber C. , Zhang Haiyang , Fuller Kathryn J. , Amiji Burhan , Anderson Ian C. , Barton Craig V. M. , Carrillo Yolima , Catunda Karen L. M. , Chandregowda Manjunatha H. , Igwenagu Chioma , Jacob Vinod , Kim Gil Won , Macdonald Catriona A. , Medlyn Belinda E. , Moore Ben D. , Pendall Elise , Plett Jonathan M. , Post Alison K. , Powell Jeff R. , Tissue David T. , Tjoelker Mark G. , Power Sally A.
Published: March 2022

Shifts in the timing, intensity and/or frequency of climate extremes, such as severe drought and heatwaves, can generate sustained shifts in ecosystem function with important ecological and economic impacts for rangelands and managed pastures. The Pastures and Climate Extremes experiment (PACE) in Southeast Australia was designed to investigate the impacts of a severe winter/spring drought (60% rainfall reduction) and, for a subset of species, a factorial combination of drought and elevated temperature (ambient +3°C) on pasture productivity. The experiment included nine common pasture and Australian rangeland species from three plant functional groups (C3 grasses, C4 grasses and legumes) planted in monoculture. Winter/spring drought resulted in productivity declines of 45% on average and up to 74% for the most affected species (Digitaria eriantha) during the 6-month treatment period, with eight of the nine species exhibiting significant yield reductions. Despite considerable variation in species’ sensitivity to drought, C4 grasses were more strongly affected by this treatment than C3 grasses or legumes. Warming also had negative effects on cool-season productivity, associated at least partially with exceedance of optimum growth temperatures in spring and indirect effects on soil water content. The combination of winter/spring drought and year-round warming resulted in the greatest yield reductions. We identified responses that were either additive (Festuca), or less-than-additive (Medicago), where warming reduced the magnitude of drought effects. Results from this study highlight the sensitivity of diverse pasture species to increases in winter and spring drought severity similar to those predicted for this region, and that anticipated benefits of cool-season warming are unlikely to be realized. Overall, the substantial negative impacts on productivity suggest that future, warmer, drier climates will result in shortfalls in cool-season forage availability, with profound implications for the livestock industry and natural grazer communities.
Climate Donations Inspired by Evidence-Based Fundraising
Authors: Ryba Ren , Dry Matthew J. , Connell Sean D.
Published: March 2022

Everyone has an opportunity to contribute to climate solutions. To help people engage with this opportunity, it is critical to understand how climate organizations and fundraisers can best communicate with people and win their financial support. In particular, fundraisers often rely on practical skills and anecdotal beliefs at the expense of scientific knowledge. Fundraisers could be motivated to achieve a substantial boost in funding for climate solutions, if there is evidence of the financial gains that science-based fundraising makes available. In this Perspective, we provide a preliminary foray into such evidence. We bring together findings from philanthropic research and climate psychology to identify what factors can help captivate donors. Then, through an experimental study of a charitable appeal for a climate charity, we show how putting these factors into practice may contribute toward an increase in donated money. This provides optimism that evidence-based fundraising can inspire donors to contribute much-needed resources toward climate solutions.
Trauma Coping Self-Efficacy Mediates Associations Between Adult Attachment and Posttraumatic Stress Symptoms
Authors: Morison Margaret , Benight Charles C.
Published: March 2022

Attachment orientations reflect individuals’ expectations for interpersonal relationships and influence emotion regulation strategies and coping. Previous research has documented that anxious and avoidant attachment orientations have deleterious effects on the trauma recovery process leaving these survivors vulnerable to posttraumatic stress disorder (PTSD) symptoms. However, avoidant attachment may be more complicated. Prior work has also found those high in avoidant attachment but also low in anxious attachment (i.e., dismissing) may not experience such vulnerabilities. Further, avoidant attachment individuals often report higher self-efficacy than their anxiously attached counterparts. The present study examined trauma coping self-efficacy (CSE-T) as a previously unexamined mechanism of action between adult attachment and PTSD symptoms. Structural equation modeling results showed that anxious attachment was associated with lower CSE-T and greater PTSD symptoms six weeks later. Further, a significant indirect effect of anxious attachment on PTSD symptoms through CSE-T was found. Contrary to hypotheses, avoidant attachment also exhibited an indirect effect on PTSD symptoms through CSE-T, such that avoidant attachment was associated with lower CSE-T, which in turn, was associated with greater PTSD symptoms. Also contrary to hypotheses, the interaction between anxious and avoidant attachment was not significantly associated with either CSE-T or PTSD symptoms. Results suggest that both anxious and avoidant attachment orientations contribute to poor self-regulation following trauma, as they undermine perceptions of trauma coping self-efficacy.
Exploring the Domain of Emotional Intelligence in Organizations: Bibliometrics, Content Analyses, Framework Development, and Research Agenda
Authors: Dong Baobao , Peng Xing , Jiang Na
Published: March 2022

Emotion is a kind of micro foundation that can affect human behaviors even in the digital era. Emotional intelligence (EI) is an important psychological factor that affects the growth and development of organizations from the view of emotion. Based on current bodies of literature, a comprehensive review of EI can contribute to its theory development in organization research and facilitate EI research burgeoning. We visualize the landscape of EI by analyzing 1,996 articles with CiteSpace their concepts, dimensions, and measurement. We propose two specific mechanisms, which clarify how individuals with high EI use emotional information to influence themselves and others. Following this, we develop a theoretical framework of EI at levels of individual, team, and organization. Finally, future directions and research agenda are addressed. This research contributes to the literature of EI and provides practical insight for practitioners.
Facts Tell, Stories Sell? Assessing the Availability Heuristic and Resistance as Cognitive Mechanisms Underlying the Persuasive Effects of Vaccination Narratives
Authors: Vandeberg Lisa , Meppelink Corine S. , Sanders José , Fransen Marieke L.
Published: March 2022

Online vaccine-critical sentiments are often expressed in appealing personal narratives, whereas vaccine-supporting information is often presented in a non-narrative, expository mode describing scientific facts. In two experiments, we empirically test whether and how these different formats impact the way in which readers process and retrieve information about childhood vaccination, and how this may impact their perceptions regarding vaccination. We assess two psychological mechanisms that are hypothesized to underlie the persuasive nature of vaccination narratives: the availability heuristic (experiment 1, N = 418) and cognitive resistance (experiment 2,N= 403). The results of experiment 1 showed no empirical evidence for the availability heuristic, but exploratory analyses did indicate that an anti-vaccination narrative (vs. expository) might reduce cognitive resistance, decrease vaccination attitudes and reduce attitude certainty in a generally pro-vaccination sample, especially for those who were more vaccine hesitant. Preregistered experiment 2 formally tested this and showed that not narrative format, but prior vaccine hesitancy predicts cognitive resistance and post-reading attitudes. Hesitant participants showed less resistance toward an anti-vaccine text than vaccine-supporting participants, as well as less positive post-reading attitudes and attitude certainty. These findings demonstrate belief consistency effects rather than narrative persuasion, which has implications for scientific research as well as public health policy.
Development of the Japanese Version of the Linguistic Inquiry and Word Count Dictionary 2015
Authors: Igarashi Tasuku , Okuda Shimpei , Sasahara Kazutoshi
Published: March 2022

The Linguistic Inquiry and Word Count Dictionary 2015 (LIWC2015) is a standard text analysis dictionary that quantifies the linguistic and psychometric properties of English words. A Japanese version of the LIWC2015 dictionary (J-LIWC2015) has been expected in the fields of natural language processing and cross-cultural research. This study aims to create the J-LIWC2015 through systematic investigations of the original dictionary and Japanese corpora. The entire LIWC2015 dictionary was initially subjected to human and machine translation into Japanese. After verifying the frequency of use of the words in large corpora, frequent words and phrases that are unique to Japanese were added to the dictionary, followed by recategorization by psychologists. The updated dictionary indicated good internal consistency, semantic equivalence with the original LIWC2015 dictionary, and good construct validity in each category. The evidence suggests that the J-LIWC2015 dictionary is a powerful research tool in computational social science to scrutinize the psychological processes behind Japanese texts and promote standardized cross-cultural investigations in combination with LIWC dictionaries in different languages.
The Impact of Consumers’ Dynamic Browsing Modes on the Effect of In-Feed Native Advertising
Authors: Xiao Bangming , Zhang Hao
Published: March 2022

As an emerging form of online display advertising, in-feed native advertising is increasingly employed in online news feed platforms. While many advertisers have largely embraced this new advertising format, the current research is full of controversy on whether the more native, the better the effect of in-feed native advertising. Based on recent studies on this emerging topic, the authors explore the effective in-feed native advertising persuasion strategies based on consumers’ dynamic online browsing modes. In study 1, the authors conducted an archived-data analysis (in co-operation with Baidu company). Results show that the match between in-feed native advertising persuasion style (implicit vs. explicit) and consumers’ real-time news feed browsing modes (convergent vs. divergent) can improve ad performance. In study 2, the authors further explained why consumers under different browsing modes respond differently (the mediation effect of self-agency vs. external agency) to specific in-feed native advertising persuasion. Our work explores the boundaries of agency theory from a dynamic perspective and helps advertisers conduct real-time and effective targeting strategies.
Construct-Oriented or Goal-Motivated? Interpreting Test Preparation of a High-Stakes Writing Test From the Perspective of Expectancy-Value Theory
Authors: Xu Shasha
Published: March 2022

Of the many possible individual factors bearing on test preparation, one is how individuals’ motivational and cognitive perceptions affect test-driven preparation practices. This study reports an investigation into test preparation of a high-stakes writing test from the perspective of expectancy-value theory. Undergraduate students (n = 623) on their test preparation for the writing tasks of China’s Graduate School Entrance English Examination (GSEEE) were recruited voluntarily from 11 universities in mainland China. The perceptions of GSEEE test takers, which included goal, task value, task demand, and expectation of success, were identified. Five types of preparation practices were identified for the GSEEE writing tasks: memorizing practice, test familiarization, comprehensive learning, skills development and drilling practice. Structural equation modeling revealed that the expectancy-value model held up well for the paths from test takers’ perceptions to test-driven preparation practices, which were not construct-oriented but goal-motivated. The GSEEE test takers’ goal, determined by the high-stakes nature of admission test, explained their motivation and determined their behavior toward test preparation. Results also indicated that task demand was inadequate to be termed a strong factor in affecting test preparation. As such, the findings of this study offer evidence regarding how an expectancy-value model fit into test preparation mechanism and provide insights into the nature and scope of test preparation for high-stakes writing tests.
Decision Making With an Alternative Mindset in an Online Shopping Environment: Identifying User Intentions Toward Facebook-Commerce
Authors: Wang Jian , Shahzad Fakhar , Khan Imran , Siyal Abdul Waheed
Published: March 2022

Considering the current global trend in the digital economy, Facebook commerce (f-commerce) is an indispensable component of today’s digital commerce. The purpose of this research is to test the proposed model to validate current theories that evaluate the relationships between online trust and customer f-commerce usage intentions. It has also been proposed to improve usage intention by integrating the relationship between perceived value and trust in electronic commerce (e-commerce). The data was gathered using a structured questionnaire and analyzed with structural equation modeling (SEM; n = 435). In this study, gender has been discussed as a moderating factor. The findings describe the positive relationships that exist between antecedents of trust and user intentions toward f-commerce. Furthermore, according to the findings of the study, females are more concerned than males about developing their intentions to utilize f-commerce for online shopping. Theoretical and practical implications are also presented in this study.
What Matters for Depression and Anxiety During the COVID-19 Quarantine?: Results of an Online Cross-Sectional Survey in Seoul, South Korea
Authors: Kwon Hye-Young , Kim Yongjoo , Lee Seung-Young
Published: March 2022

Background

Amid the COVID-19 pandemic, quarantine measures are key to containing the spread of the virus. Millions of people have been required to quarantine throughout the pandemic; the quarantine itself is considered detrimental to mental health conditions.

Objective

This study aims to investigate the factors associated with depression and anxiety among quarantined people in Seoul, South Korea.

Methods

An online cross-sectional survey was administered from October to November 2020 involving people who were living in Seoul, aged 19 years or above, under a 2-week mandatory quarantine. Their mental health status was measured using the Patient Health Questionnares-9 (PHQ-9) and the General Anxiety Disorder-7 (GAD-7).

Results

Overall, 1,135 respondents were finally included, resulting in a 22.0% response rate. After controlling for potential confounders, variables, such as the “second half of quarantine period” (OR = 1.78 95% CI: 1.10–2.88), “female” (OR = 1.91 95% CI: 1.16–3.16), and “having pre-existing depression” (OR = 8.03 95% CI: 2.96–21.78) were significantly associated with depression while being quarantined. Those with correct knowledge about the rationale behind for the quarantine (OR = 0.39 95% CI: 0.21–0.72), an understanding of quarantine rules (OR = 0.68 95%CI: 0.52–0.91), and those who felt supported by others (OR = 0.74 95% CI: 0.55–0.99) were less likely to develop depression while quarantining. Similarly, anxiety was significantly associated with the second week (OR = 4.18 95% CI: 1.44–12.09), those with an unstable job status (OR = 3.95 95% CI: 1.60–9.79), perceived support (OR = 0.66, 95% CI: 0.45–0.96), and the fear of being infected (OR = 7.22 95% CI: 1.04–49.95).

Conclusions

This study highlights the need to develop precautionary measures to prevent depression and anxiety among people undergoing COVID-19 quarantine. In particular, individuals with depression prior to quarantine should be carefully monitored during the quarantine. Further studies with larger populations are needed.
Social Network Site Appearance Comparison's Prediction of Anxiety Among Chinese Females: The Mediation Effect of Body Area Satisfaction, Overweight Preoccupation, and Self-Esteem
Authors: Hai Ri , Yang Yin
Published: March 2022

Social network site appearance comparison refers to a tendency to compare the body image of one-self to others when using social network sites. It was found to be associated with negative emotions, for example, depression, among young females, and this association was mediated by body image and self-esteem. However, researches on the chain-mediating role of body image and self-esteem in anxiety had been limited. Therefore, the current study examined the chain-mediating role between social network site comparison and anxiety among 320 Chinese females, using the Social Network Site Appearance Comparison Scale (SNSACS), Multidimensional Body–Self Relations Questionnaire (MBSRQ), Self-esteem Scale (SES), and the anxiety subscale of Depression-Anxiety-Stress Scale (DASS). Results revealed that (1) SNSACS, SES, and DASS anxiety scores were significantly correlated with each other, and the scores of two MBSRQ subscale, that is, body area satisfaction and overweight preoccupation, were significantly correlated with SNSACS, SES, and DASS anxiety scores; (2) body area satisfaction and self-esteem played a chain-mediating role in the effect of social network site appearance comparison on anxiety; (3) overweight preoccupation and self-esteem played a chain-mediating role in the effect of social network site appearance comparison on anxiety. The findings may inspire new ideas for understanding how social comparison triggers anxiety and for developing methods to reduce anxiety derived from appearance comparison among Chinese females.
Rationale and Description of Implementation of Regional Collaborative Service Model for Enhancing Psychosocial Wellbeing of Children and Families—Oulu Collective Impact Study
Authors: Takalo Tuula , Räsänen Sami , Hakko Helinä , Juutinen Aapo , Niemelä Mika
Published: March 2022

Background

The psychosocial wellbeing of children and adolescents is an ongoing global concern. Despite positive outcomes of child- and family-focused programs, the fragmentation of services presents challenges. To enhance harmonization and diminish fragmentation of service policies, we implement a preventive collaborative service model for children and families. The rationale for our study is based on analyses of national and local data before implementing the service model in the pilot area.

Methods

The need for a preventive service model for children and families was demonstrated using national and local data sources. First, a national school health survey was utilized to screen adolescents' perceptions of their depressive symptoms and support. Second, time trends in child and adolescent psychiatric and child protection service use were investigated. For these aims, epidemiological data of the study area (city of Oulu) were compared with data from the whole country (Finland). Third, local usage data of the preventive stand-alone Let's Talk About Children (LT) intervention before the service model implementation were evaluated. After these analyses, Let's Talk About Children Service Model (LT-SM) implementation in the pilot area is described in detail.

Results

The background data showed that 17% of the adolescents in the study area had reported depressive symptoms, and almost half of them had not received professional help. Child and adolescent psychiatric outpatient visits had increased during the last decade, but the number of visits remains lower in the study area compared with the country as a whole. The number of adolescent psychiatric inpatient days had increased contrary to a decreasing national trend. The number of urgent child welfare placements was also higher compared with the whole country. The local LT intervention data revealed very low utilization rates. These results indicated a necessity to enhance preventive and collaborative support for children and their families. This article describes the implementation of the LT-SM.

Discussion

We demonstrated excessive use of curative services in social and health care and insufficient usage of the stand-alone preventive intervention. The LT-SM is now piloted in one regional service area of the city of Oulu. Its effectiveness will be evaluated when enough data have been accumulated for statistical analyses.