bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of Poorly Cohesive and Signet Ring Cell Carcinomas and Identification of PTPRM as a Diagnostic Marker
Authors: Bae Go Eun , Kang Sun Hyung , Kim Ju Seok , Kim Seok-Hwan , Kim Kyung-Hee , Kim Jin-Man , Suh Kwang-Sun , Park Hyung Kyu , Kang Dong-Wook , Lee Hyunjung , Yeo Min-Kyung
Published: May 2022

Background and aims. Signet ring cell (SRC) and poorly cohesive (PC) gastric carcinomas are morphologically similar but exhibit different biological behavior. We compared the clinical and molecular characteristics of SRC and PC carcinomas. Methods. Diffuse-type gastric cancer (GC) cases were classified into SRC carcinomas (>90% of SRCs), PC carcinomas (<10% of SRCs), and combined PC/SRC carcinomas (≤90% but ≥10% of SRCs). The gene expression patterns in SRC and PC carcinomas were examined by transcriptome and protein immunohistochemistry analyses, and diagnostic and prognostic biomarkers were identified. Results. SRC and PC carcinomas showed significantly different clinical behaviors but shared common RNA expression patterns. PC carcinomas showed an increased expression of genes related to cancer progression. Among genes differentially expressed between PC and SRC carcinomas, protein tyrosine phosphatase receptor type M (PTPRM) was overexpressed in PC and related to unfavorable clinical factors. Conclusion. We found that PC and SRC carcinomas had distinct clinical characteristics and should be classified as different carcinoma types. PTPRM was identified as a potential diagnostic and prognostic biomarker for PC carcinomas and could represent a potential therapeutic target.
Development and Validation of the PaP Score Nomogram for Terminally Ill Cancer Patients
Authors: Scarpi Emanuela , Nanni Oriana , Maltoni Marco
Published: May 2022

The validated Palliative Prognostic (PaP) score predicts survival in terminally ill cancer patients, assigning patients to three different risk groups according to a 30-day survival probability: group A, >70%; group B, 30–70%; and group C, <30%. We aimed to develop and validate a PaP nomogram to provide individualized prediction of survival at 15, 30 and 60 days. Three cohorts of consecutive terminally ill cancer patients were used: one (n = 519) for nomogram development and internal validation, and a second (n = 451) and third (n = 549) for external validation. Multivariate analyses included dyspnea, anorexia, Karnofsky performance status, clinical prediction of survival, total white blood count and lymphocyte percentage. The predictive accuracy of the nomogram was determined by Harrell’s concordance index (95% CI), and calibration plots were generated. The nomogram had a concordance index of 0.74 (0.72–0.75) and showed good calibration. The internal validation showed no departures from ideal prediction. The accuracy of the nomogram at 15, 30 and 60 days was 74% (70–77), 89% (85–92) and 72% (68–76) in the external validation cohorts, respectively. The PaP nomogram predicts the individualized estimate of survival and could greatly facilitate clinical care decision-making at the end of life.
Carbon Electrodes with Gold Nanoparticles for the Electrochemical Detection of miRNA 21-5p
Authors: Serrano Verónica Morgado , Silva Inês Simões Patrício , Cardoso Ana Rita , Sales Maria Goreti Ferreira
Published: May 2022

Extracellular vesicles are involved in many physiological and pathological activities. They transport miRNAs to recipient cells during their role in intercellular communication, making them emerging biomarkers of many diseases. Interest in exosomal miRNAs has grown after they have shown numerous advantages as biomarkers for diagnosis, prognosis, and evaluation of cancer treatment. This work describes the development of a biosensor for the detection of 21-5p miRNA in human serum using screen-printed carbon electrodes modified with gold nanoparticles fabricated in situ, an innovative approach to avoid the use of more expensive gold substrates that provide better analytical outputs. The several variables involved in the assembly of the biosensor were optimized by univariant mode. Under the best conditions, the biosensor showed a linear response from 0.010 fM to 10 pM, with a limit of detection (LOD) of 4.31 aM. The sensitivity was 0.3718 relative Ω per decade concentration in buffered saline solutions, and the standard deviation of the blank is 2.94 Ω. A linear response was also obtained when human serum samples were tested with miRNA 21-5p. Interference from similar miRNA and miss-match miRNA sequences was evaluated and good selectivity for miRNA 21-5p was observed. Overall, the device proposed is an alternative approach to gold substrates, which typically result in more sensitive systems and lower LODs, which compares favorably to current gold-based biosensors for the targeted miRNA. This design may be further extended to other nucleic acids.
Unexpected Huge Prevalence of Intracardiac Extension of Wilms Tumor—A Single Center Experience from a Ugandan Hospital
Authors: Mapelli Massimo , Zagni Paola , Ferrara Roberto , Calbi Valeria , Mattavelli Irene , Muratori Manuela , Kansiime Jackson , Opira Cyprian , Agostoni Piergiuseppe
Published: May 2022

Wilms tumor (WT) is the most common primary renal malignancy in young children. WT vascular extension to the inferior vena cava (IVC) occurs in 4–10% of cases and can reach the right atrium (RA) in 1%. Data on WT clinical presentation and outcome in developing countries are limited. The aim of the present study is to describe the prevalence of intracardiac extension in a consecutive population of WT patients observed in a large non-profit Ugandan hospital. A total of 16 patients with a histological diagnosis of 29 WT were screened in a 6-month period. Patient n°2, a 3 y/o child, presented with a 3-week history of abdominal distension, difficulty in breathing, and swelling of the lower limbs. A cardiovascular system exam showed rhythmic heart sounds, a heart rate of 110 beats per minute, and a pansystolic murmur on the tricuspid area; the abdomen was grossly distended with a palpable mass in the right flank, hepatomegaly, and splenomegaly. An abdomen ultrasound showed an intra-abdominal tumor, involving the right kidney and the liver and extended to the IVC. An ultrasound guided biopsy showed a picture consistent with WT. Cardiac echo showed a huge, mobile, cardiac mass attached to the right side of the interatrial septum, involving the tricuspid valve annulus, causing a “functional” tricuspid stenosis. The patient died of cardiogenic shock 7 days after admission. Patient n°3, a 3 y/o child, presented with analogue symptoms and the same diagnosis. The cardiac echo showed a round mass in the RA. Thirteen more patients were screened with cardiac echo, showing a normal heart picture. In our limited series, we found WT cardiac extension in three patients over 16 (19%). Cardiac echo performed routinely can lead to a better staging, prognostic, and therapeutic assessment. In our setting, the intra-cardiac extension could be more frequent than previously reported and might have prognostic implications.
Septic Arthritis and Related Conditions
Authors: Giani Teresa , Cimaz Rolando
Published: May 2022

Arthritis is a common condition that any pediatrician may have to deal with [...]
Skin Barrier Enhancing Alternative Preservation Strategy of O/W Emulsions by Water Activity Reduction with Natural Multifunctional Ingredients
Authors: Nadarzynski Alexandra , Scholz Jonas , Schröder Markus S.
Published: May 2022

Water activity (aw) as an important parameter for self-preservation can help to control microbial growth in cosmetic formulations. However, high amounts of water-binding substances are required to lower the aw enough to affect microbial growth. Since consequences for the skin barrier have been poorly studied so far, we investigated the effect of aw-lowering agents on both the antimicrobial properties of o/w emulsions and skin physiological parameters. A combination of selected natural humectants (Sodium lactate, Propanediol, Erythritol, Betaine and Sodium PCA) with a total concentration of 28 wt% in an o/w emulsion was able to reduce its aw from 0.980 ± 0.003 to 0.865 ± 0.005. The challenge test results of the aw-lowered emulsion showed a convincing microbial count reduction in potentially pathogenic microorganisms. The addition of as little as 0.5% of the antimicrobial multifunctionals Glyceryl Caprylate and Magnolia Officinalis Bark Extract further enhanced the antimicrobial effect, resulting in adequate antimicrobial protection. Moreover, twice-daily application of the aw-lowered emulsion for a period of four weeks led to a skin barrier-enhancing effect: TEWL significantly decreased, and SC hydration significantly increased. Thus, we present an opportunity to replace conventional preservatives with a natural alternative preservation strategy that has been shown to offer benefits for the skin.
Mechanisms of Selected Anionic Dye Removal by Clinoptilolite
Authors: Wang Xisen , Baker Jessica , Carlson Kristen , Li Zhaohui
Published: May 2022

The extensive use of color dyes in modern society has resulted in serious concerns of water contamination. Many organic dyes bear charges; thus, materials of opposite charges have been tested for sorptive removal. However, the results from several studies also showed that anionic dyes methyl orange (MO) and alizarin red S (ARS) could be removed from water using minerals of negative charges, but the mechanisms were not addressed. In this study, negatively charged clinoptilolite was tested for its removal of anionic dyes MO and ARS from water under different physico-chemical conditions and to investigate the mechanism of Mo and ARS removal. The sorption capacities were 166 and 92 mmol/kg for MO and ARS, respectively, confirming the uptake of anionic dyes on negatively charged framework silicates. The influence of solution pH and ionic strength on MO removal was minimal, indicating the strong affinity of anionic dyes for clinoptilolite in comparison to other inorganic species. It was speculated that the N in the dimethyl group may bear a partial positive charge, which may have a net electrostatic attraction to the negatively charged mineral surfaces for MO sorption. For ARS, sorption may involve hydrogen bonding formation between the dye and the clinoptilolite. Moreover, under the experimental conditions, the MO molecules form dimers in solution via dimeric π-π interactions. Thus, the sorption of the dimers or aggregation of the MO monomers and dimers on clinoptilolite surface was attributed to additional MO removal, as suggested by molecular dynamic simulations. The speculation was supported by FTIR analyses and molecular dynamic simulations. As such, negatively charged Earth materials may be used as sorbents for the removal of certain anionic dyes via sorption, a new perspective for the innovative use of Earth materials.
Study of PDMS Microchannels for Liquid Crystalline Optofluidic Devices in Waveguiding Photonic Systems
Authors: Baczyński Szymon , Sobotka Piotr , Marchlewicz Kasper , Juchniewicz Marcin , Dybko Artur , Rutkowska Katarzyna A.
Published: May 2022

Microchannels in LC:PDMS structures must be of good quality and suitable geometry to achieve the desired orientation of the liquid crystalline molecules inside. When applying a casting technique, with the molds obtained even by the most accurate method, i.e., photolithography, it is still crucial to inspect the cross-section of the structure and the surface roughness of the PDMS material. This paper presents a study of PDMS microchannels using a Scanning Electron Microscope (SEM) to make such a characterization as accurate as possible. By comparing images of the samples taken using standard polarized light microscopy and SEM, it is likely to understand the mechanism of the liquid crystal molecular orientation occurring in the samples. The results obtained in this work may be used for numerical simulations and further development of LC:PDMS structures.
Biological Aspects, Fisheries, and Aquaculture of Yesso Scallops in Russian Waters of the Sea of Japan
Authors: Dvoretsky Alexander G. , Dvoretsky Vladimir G.
Published: May 2022

Scallops are bivalve filter-feeding mollusks that can attain a large size and have great importance in terms of their ecological roles and commercial value. Overfishing has led to a decrease in scallop stocks worldwide, leading to intense development of the aquaculture industry. The latter is well-established in Asian countries in the East Sea and Sea of Japan. In this paper, we summarized information regarding the biology, stock dynamics, and fishery of yesso scallops inhabiting Russian waters of the Sea of Japan. This species has relatively rapid growth rates and reaches a marketable size of 100 mm in shell height at age 3–5 years. In Russian waters, the total commercial stock of yesso scallops in 2021 was estimated at 2784 t. Commercial fisheries have been banned since 2020 due to the depletion of natural stocks as a result of illegal fishing and overexploitation. The total allowable catch for yesso scallops has been set at 3 t for monitoring and recreational purposes. The cultivation of the scallops includes spat collection, spat intermediate culture, and final grow-out on the seafloor or in suspended cages. In the past decade, this industry has demonstrated rapid growth and currently accounts for >16,000 t per year. Environmental fluctuations and epizootics seem to be the most important challenges for the scallop aquaculture sector in the Sea of Japan.
Can Health Improvements from a Community-Based Exercise and Lifestyle Program for Older Adults with Type 2 Diabetes Be Maintained? A Follow up Study
Authors: Kirwan Morwenna , Gwynne Kylie , Laing Thomas , Hay Mellissa , Chowdhury Noureen , Chiu Christine L.
Published: May 2022

Background: Older people consistently report a desire to remain at home. Beat It is a community-based exercise and lifestyle intervention that uses evidence-based strategies to assist older people with type 2 diabetes mellitus (T2DM) to improve physical and functional fitness, which are crucial to maintain independence. This follow up, real-world study assessed the efficacy of Beat It and whether older adults with T2DM were able to maintain improvements in physical activity, waist circumference and fitness one year post completion. Methods: We have previously reported methods and results of short-term outcomes of Beat It. This paper reports anthropometric measurements and physical fitness outcomes of Beat it at 12-months post program completion and compares them to validated standards of fitness required to retain physical independence. Results: Improvements that were observed post program were maintained at 12 months (n = 43). While the number of participants who met fitness standards increased post program, not all increases were maintained at 12 months. Conclusions: This study provides promising early evidence that an eight-week, twenty-hour community-based clinician-led exercise and lifestyle program can improve health outcomes in older adults with T2DM which were retained for at least a year after program completion.
Utility of Next-Generation Sequencing in the Reconstruction of Clonal Architecture in a Patient with an EGFR Mutated Advanced Non-Small Cell Lung Cancer: A Case Report
Authors: Simarro Javier , Pérez-Simó Gema , Mancheño Nuria , Muñoz-Núñez Carlos Francisco , Cases Enrique , Juan Óscar , Palanca Sarai
Published: May 2022

EGFR tyrosine kinase inhibitors (EGFR-TKIs) have revolutionized the treatment of non-small cell lung cancer (NSCLC) patients with activating EGFR mutations. However, targeted therapies impose a strong selective pressure against the coexisting tumor populations that lead to the emergence of resistant clones. Molecular characterization of the disease is essential for the clinical management of the patient, both at diagnosis and after progression. Next-generation sequencing (NGS) has been established as a technique capable of providing clinically useful molecular profiling of the disease in tissue samples and in non-invasive liquid biopsy samples (LB). Here, we describe a case report of a patient with metastatic NSCLC harboring EGFR mutation who developed two independent resistance mechanisms (EGFR-T790M and TP53 + RB1 mutations) to dacomitinib. Osimertinib given as a second-line treatment eliminated the EGFR-T790M population and simultaneously consolidated the proliferation of the TP53 + RB1 clone that eventually led to the histologic transformation to small-cell lung cancer (SCLC). Comprehensive NGS profiling revealed the presence of the TP53 + RB1 clone in the pretreatment biopsy, while EGFR-T790M was only detected after progression on dacomitinib. Implementation of NGS studies in routine molecular diagnosis of tissue and LB samples provides a more comprehensive view of the clonal architecture of the disease in order to guide therapeutic decision-making.
Faster Time to Treatment Decision of Viscoelastic Coagulation Test Results through Improved Perception with the Animated Visual Clot: A Multicenter Comparative Eye-Tracking Study
Authors: Castellucci Clara , Braun Julia , Said Sadiq , Roche Tadzio Raoul , Nöthiger Christoph B. , Spahn Donat R. , Tscholl David W. , Akbas Samira
Published: May 2022

As the interpretation of viscoelastic coagulation test results remains challenging, we created Visual Clot, an animated blood clot aiming to facilitate raw rotational thromboelastometry (ROTEM) parameters. This study investigated anesthesia personnel’s cognitive processing in managing simulated bleeding scenarios using eye-tracking technology. This multicenter, international, computer-based study across five large, central European hospitals included 35 participants with minimal to no prior experience interpreting viscoelastic test results. Using eye-tracking technology and an iPad tagged with quick response codes, we defined the time to treatment decision and the time on screen surface in seconds of correctly solved scenarios as our outcomes. The median time to treatment decision was 52 s for Visual Clot and 205 s for ROTEM (p < 0.0001). The probability of solving the scenario correctly was more than 8 times higher when using Visual Clot than when using ROTEM (Hazard ratio [HR] 8.54, 95% CI from 6.5 to 11.21; p < 0.0001). Out of 194 correctly answered scenarios of participants with the eye-tracker, 154 (79.4%) were solved with Visual Clot and 40 (20.6%) with ROTEM. Participants spent on average 30 s less looking at the screen surface with Visual Clot compared to ROTEM (Coefficient −30.74 s, 95% CI from −39.27 to −22.27; p < 0.0001). For a comparison of the two modalities in terms of information transfer, we calculated the percentage of time on the screen surface of the overall time to treatment decision, which with Visual Clot was 14 percentage points shorter than with ROTEM (Coefficient −14.55, 95% CI from −20.05 to −9.12; p < 0.0001). Visual Clot seems to improve perception and detection of coagulopathies and leads to earlier initiation of the appropriate treatment. In a high-pressure working environment such as the operating and the resuscitation room, correct and timely decisions regarding bleeding management may have a relevant impact on patients’ outcomes.
Medication-Related Osteonecrosis of the Jaw in Dental Practice: A Retrospective Analysis of Data from the Milan Cohort
Authors: Mirelli Cristina , Marino Sonia , Bovio Andrea , Pederielli Sara , Dall’Agnola Cristina , Gianni Aldo Bruno , Biagi Roberto
Published: May 2022

A retrospective analysis was performed with the aim of understanding whether the risk factors showed in the literature for medication-related osteonecrosis of the jaws (MRONJ) in cancer patients are also relevant in osteoporotic patients taking antiresorptive drugs (ARDs). Data were retrospectively pooled from health records of patients on ARDs who requested a dental visit between January 2006 and April 2020 in the Dental Unit at Fondazione Ca’ Granda IRCCS Ospedale Maggiore Policlinico, University of Milan. A total of 434 patients were included. The following variables were collected: sex, age, smoking habit, type of ARD, duration of treatment, route of administration, therapeutic indication, concurrent systemic therapies and pathologies. Statistical analysis confirmed the relevance of chemotherapy, smoking, and immunosuppressive drugs as risk factors. In addition, a higher frequency of MRONJ in osteoporotic patients was reported in our cohort in association with an immunodeficiency disorder of variable origin. In conclusion, the identification of individual risk-profile before dental treatments is crucial for prevention. Anamnesis should include main risk factors, such as immunosuppression, dental extractions, smoking, trauma, and poor dental health. Nevertheless, our suggestion for dental professionals is to conduct a complete medical history of patients who mention long-term per oral therapies with ARDs for osteoporosis. Osteoporotic, as well as cancer patients, may also benefit from periodic monitoring of the ARDs therapy in order to prevent MRONJ.
Unpacking the Shortcomings of “College and Career Readiness” as an Educative Approach in Urban Schools as Preparation for Tomorrow’s Economy
Authors: Benson Keith E. , Owens Leah Z.
Published: May 2022

As the language of “college and career readiness” continues to permeate American public education, the fixation on preparing students for college and careers is potentially harmful for students, particularly urban students of color. In promoting “college and career readiness”, certain assumptions are taken for granted: that American schools are sites of egalitarian meritocracy and not spaces of social reproduction; that tomorrow’s job market desires more individuals with formal education, and that the jobs market will be viable for tomorrow’s willing workers. Here, we argue that as “college and career readiness” continues to be the dominant approach in American schools, it ignores the realities that the workplace of tomorrow is growing harsher as corporations continue their efforts to maximize profits by keeping labor costs low by reducing worker participation and seeking cheaper labor. Simultaneously, American students of color are more vulnerable to tomorrow’s workplace in that they continue to experience racial discrimination coupled with the growing tenuous nature of the future domestic job market. Thus, students who are being schooled in “college and career readiness” have to contend with the possibility that, though they are more formally educated, the economy of tomorrow may still deem them expendable.
Optimal Dual Active Bridge DC-DC Converter Operation with Minimal Reactive Power for Battery Electric Vehicles Using Model Predictive Control
Authors: Guennouni Nasr , Chebak Ahmed , Machkour Nadia
Published: May 2022

The dual active bridge DC-DC converter is a promising power converter used in several applications. Much research has been focusing on the study of such a converter from different angles. In this paper, an optimal design of the DAB converter is proposed to provide minimal reactive power in addition to reduced weight and size for the converter magnetic components in order to assure the DC-DC conversion stage of battery electric vehicles’ powertrains. Two modes of operation are considered in order to fulfill such a requirement and minimize reactive power of the converter (circulating current/conduction losses): an optimal extended phase shift (EPS) modulation along with an optimal triangular phase shift (TrgPS) modulation. The operation of the DAB converter under the two modes is being driven using a model predictive controller. Simulation results using MATLAB/Simulink presented in the paper show that the operation of the DAB converter for such an application is optimal when operating under optimal TrgPS modulation. In addition to the aforementioned features, it also solves many other concerns, such as transient load fluctuation and input voltage disturbance effects, and provides ease of control.
A Novel Virtual Power Plant Uncertainty Modeling Framework Using Unscented Transform
Authors: Ramos Lucas Feksa , Canha Luciane Neves , Prado Josue Campos do , de Menezes Leonardo Rodrigues Araujo Xavier
Published: May 2022

This paper proposes a new strategy for modeling predictability uncertainty in a stochastic context for decision making within a Virtual Power Plant (VPP). Modeling variable renewable energy generation is an essential step for effective VPP planning and operation. However, it is also a challenging task due to the uncertain nature of its sources. Therefore, developing tools to effectively predict these uncertainties is essential for the optimal participation of VPPs in the electricity market. The purpose of this paper is to present a novel method to model the uncertainties associated with energy dispatching in a VPP using the Unscented Transform (UT) method. The proposed algorithm minimizes the risks associated with the VPP operation in a computationally efficient and simple manner, and can be used in real-time on a power system. The proposed framework was evaluated based on an Electric Power System (EPS) model with historical data. Case studies have been performed to demonstrate the effectiveness of the proposed framework in minimizing power demand and renewable-energy-forecasting uncertainty for a VPP.
Computationally Efficient State-of-Charge Estimation in Li-Ion Batteries Using Enhanced Dual-Kalman Filter
Authors: Wadi Ali , Abdel-Hafez Mamoun , Hussein Ala A.
Published: May 2022

This paper proposes a state-of-charge estimation technique to meet highly dynamic power requirements in electric vehicles. When the power going in/out the battery is highly dynamic, the statistics of the measurement noise are expected to deviate and maybe change over time from the expected laboratory specified values. Therefore, we propose to integrate adaptive noise identification with the dual-Kalman filter to obtain a robust and computationally-efficient estimation. The proposed technique is verified at the pack and cell levels using a 3.6 V lithium-ion battery cell and a 12.8 V lithium-ion battery pack. Standardized electric vehicle tests are conducted and used to validate the proposed technique, such as dynamic stress test, urban dynamometer driving schedule, and constant-current discharge tests at different temperatures. Results demonstrate a sustained improvement in the estimation accuracy and a high robustness due to immunity to changes in the statistics of the process and measurement noise sequences using the proposed technique.
ADRC Control System of PMLSM Based on Novel Non-Singular Terminal Sliding Mode Observer
Authors: Li Zheng , Zhang Zihao , Wang Jinsong , Wang Shaohua , Chen Xuetong , Sun Hexu
Published: May 2022

In an attempt to solve the problem of the many parameters of the traditional active disturbance rejection controller (ADRC) and to accurately estimate the mover position and speed required by a permanent magnet synchronous linear motor (PMLSM) system, an improved ADRC and a novel nonsingular fast terminal sliding mode observer (NFTSMO) are proposed. Firstly, the traditional first-order ADRC is simplified, the tracking differentiator (TD) module is removed, and the direct error is used to replace the nonlinear function in the extended state observer (ESO) and nonlinear state error feedback (NLSEF) module. Based on the traditional NFTSMO, the smooth back electromotive force (EMF) is obtained by adding the TD to reduce the phase delay caused by the low-pass filter in the traditional sliding mode observer (SMO), and the actuator position and speed information are modulated from the observed back EMF based on the principle of a phase-locked loop (PLL). Simulation and experiments show that this method not only simplifies the system structure of PMLSM but also optimizes many parameters in ADRC while retaining the original excellent performance. Compared with the traditional NFTSMO, the improved NFTSMO enhances the observation accuracy, reduces the chattering phenomenon of the system, and improves the robustness of the system.
A Machine Learning Modeling Framework for Predictive Maintenance Based on Equipment Load Cycle: An Application in a Real World Case
Authors: Vallim Filho Arnaldo Rabello de Aguiar , Farina Moraes Daniel , Bhering de Aguiar Vallim Marco Vinicius , Santos da Silva Leilton , da Silva Leandro Augusto
Published: May 2022

From a practical point of view, a turbine load cycle (TLC) is defined as the time a turbine in a power plant remains in operation. TLC is used by many electric power plants as a stop indicator for turbine maintenance. In traditional operations, a maximum time for the operation of a turbine is usually estimated and, based on the TLC, the remaining operating time until the equipment is subjected to new maintenance is determined. Today, however, a better process is possible, as there are many turbines with sensors that carry out the telemetry of the operation, and machine learning (ML) models can use this data to support decision making, predicting the optimal time for equipment to stop, from the actual need for maintenance. This is predictive maintenance, and it is widely used in Industry 4.0 contexts. However, knowing which data must be collected by the sensors (the variables), and their impact on the training of an ML algorithm, is a challenge to be explored on a case-by-case basis. In this work, we propose a framework for mapping sensors related to a turbine in a hydroelectric power plant and the selection of variables involved in the load cycle to: (i) investigate whether the data allow identification of the future moment of maintenance, which is done by exploring and comparing four ML algorithms; (ii) discover which are the most important variables (MIV) for each algorithm in predicting the need for maintenance in a given time horizon; (iii) combine the MIV of each algorithm through weighting criteria, identifying the most relevant variables of the studied data set; (iv) develop a methodology to label the data in such a way that the problem of forecasting a future need for maintenance becomes a problem of binary classification (need for maintenance: yes or no) in a time horizon. The resulting framework was applied to a real problem, and the results obtained pointed to rates of maintenance identification with very high accuracies, in the order of 98%.
Energy Efficient UAV Flight Control Method in an Environment with Obstacles and Gusts of Wind
Authors: Chodnicki Marcin , Siemiatkowska Barbara , Stecz Wojciech , Stępień Sławomir
Published: May 2022

This article presents an energy-efficient method of controlling unmanned aircraft (fixed-wing UAVs), which consists of three groups of algorithms: aerial vehicle route planning, in-flight control, and algorithms to correct the preplanned flight trajectory. All algorithms shall take into account the existence of obstacles that the UAV must avoid and wind gusts in the UAV’s area of operation. Tests were carried out on the basis of the UAV mathematical model, stabilization and navigation algorithms, and Dryden turbulence model, considering the parameters of the UAV’s propulsion system. The work includes a detailed description of constructing a network of connection that is used to plan a UAV mission. It presents the algorithm for determining the actual distances between the different points in the field of action, which takes into account the existence of obstacles. The algorithm shall be based on methods for determining the flight trajectory on a hexagonal grid. It presents the developed proprietary UAV path planning algorithm based on a model from a group of algorithms of mixed integer linear problem (MILP) optimization. It presents the manner in which the pre-prepared flight path was used by UAV controllers that supervised the flight along the preset path. It details the architecture of contemporary unmanned aerial vehicles, which have embedded capability to realize autonomous missions, which require the integration of UAV systems into the route planning algorithms set out in the article. Particular attention has been paid to the planning and implementation methods of UAV missions under conditions where wind gusts are present, which support the determination of UAV flight routes to minimize the vehicle’s energy consumption. The models developed were tested within a computer architecture based on ARM processors using the hardware-in-the-loop (HIL) technique, which is commonly used to control unmanned vehicles. The presented solution makes use of two computers: FCC (flight control computer) based on a real-time operating system (RTOS) and MC (mission computer) based on Linux and integrated with the Robot Operating System (ROS). A new contribution of this work is the integration of planning and monitoring methods for the implementation of missions aimed at minimizing energy consumption of the vehicle, taking into account wind conditions.
Reclaiming the Windy Commons: Landownership, Wind Rights, and the Assetization of Renewable Resources
Authors: Wade Robert , Ellis Geraint
Published: May 2022

The ‘second phase’ of the energy transition involves large-scale rollout of renewables, raising wider questions about arrangements for the management and ownership of such resources and how costs and benefits should be distributed. Ideas and practices such as ‘community energy’ and ‘prosumption’ capture the potential for more decentralised systems of ownership and control inherent in renewable energy technologies. However, until now, ownership and control of the key biophysical resources (e.g., wind, wave, solar, geothermal) underpinning the transition have received surprisingly little attention, given the potential for wealth creation and issues of justice that underpin their use. This paper explores this issue using the idea of ‘wind rights’, which highlights the numerous social actors who have rights or claims to use and benefit from wind resources. Key among these are landowners who are silently enclosing the ‘windy commons’ to extract ‘wind rents’ from monopoly property rights. This has profound (but undertheorised) distributive and structural ramifications for the energy transition. Despite this, and with some recent notable exceptions, much energy transition research in social science and humanities portrays landowners as taken-for-granted, apolitical, and sometimes marginal (ised) stakeholders. Combining a Marxist, class-based approach to landownership and wind rent with Ostromian institutional analysis, this paper reviews and expands the (predominantly legal) literature on wind rights. This deepens the understanding of the concept of ‘wind rights’, highlighting that in many instances wind resources are de facto privatised/enclosed via ‘proxy wind rights’ for landowners. We also indicate some alternative wind rights configurations, including nationally and commonly managed wind resources. This analysis leads to a consideration of the potential long-term benefits of alternative socially orientated property rights arrangements, including community wind rights or nationalisation of the wind resource. These social wind rights arrangements could play a key role in securing a more just and widely supported transition.
Numerical Simulation of Erosion Characteristics and Residual Life Prediction of Defective Pipelines Based on Extreme Learning Machine
Authors: Wang Qi , Sun Chao , Li Yuelin , Liu Yuechan
Published: May 2022

Aiming to solve the problem that the residual life of defective elbows is difficult to predict and the prediction accuracy of a traditional extreme learning machine (ELM) is unsatisfactory, a genetic algorithm optimization neural network extreme learning machine method (GA-ELM) that can effectively predict erosion rate and residual life is proposed. In this method, the input weight and hidden layer node threshold of the hidden layer node is mapped to GA, and the input weight and threshold of the ELM network error is selected by GA, which improves the generalization performance of the ELM. Firstly, the effects of solid particle velocity, particle size, and mass flow rate on the erosion of elbow are studied, and the erosion rates under the conditions of point erosion defect, groove defect, and double groove erosion defect are calculated. On this basis, the optimized GA-ELM network model is used to predict the residual life of the pipelines and then compared with the traditional ELM network model. The results show that the maximum erosion rate of defect free elbow is linearly correlated with solid particle velocity, particle size, and mass flow rate; The maximum erosion rate of defective bend is higher than that of nondefective bends, and the maximum erosion rate of defective bend is linearly related to mass flow rate, but nonlinear to solid particle flow rate and particle size; the GA-ELM model can effectively predict the erosion residual life of a defective elbow. The prediction accuracy and generalization ability of the GA-ELM model are better than those of the traditional ELM model.
An Approach to the Design and the Interactions of a Fully Superconducting Synchronous Generator and Its Power Converter
Authors: Lengsfeld Sebastian , Sprunck Sebastian , Frank Simon Robin , Jung Marco , Hiller Marc , Ponick Bernd , Mersche Stefan
Published: May 2022

The design of a fully superconducting wind power generator is influenced by several factors. Among them, a low number of pole pairs is desirable to achieve low AC losses in the superconducting stator winding, which greatly influences the cooling system design and, consecutively, the efficiency of the entire wind power plant. However, it has been identified that a low number of pole pairs in a superconducting generator tends to greatly increase its output voltage, which in turn creates challenging conditions for the necessary power electronic converter. This study highlights the interdependencies between the design of a fully superconducting 10 MW wind power generator and the corresponding design of its power electronic converter.
Unique Land Cover Classification to Assess Day-Roost Habitat Selection of Northern Long-Eared Bats on the Coastal Plain of North Carolina, USA
Authors: De La Cruz Jesse L. , True Michael C. , Taylor Hila , Brown Dorothy C. , Ford W. Mark
Published: May 2022

Reproductively successful and over-wintering populations of the endangered northern long-eared bat (Myotis septentrionalis) have recently been discovered on the Coastal Plain of North Carolina. Empirical data on resource selection within the region is limited, likely hindering management of these coastal forests. Our objectives were to determine roosting home range size, selection of day-roost tree species, second- and third-order roosting habitat selection, and to quantify the overall availability of resources in the surrounding landscape. We found core and peripheral roosting home range estimates were large, yet similar to observations from other areas of contiguous forests. Prior to juvenile volancy, female northern long-eared bats appear to select red maple (Acer rubrum), water ash (Fraxinus caroliniana), and loblolly pine (Pinus taeda) as day-roosts, but then use sweetgum (Liquidambar styraciflua), swamp bay (Persea palustris), and water tupelo (Nyssa aquatica) after juvenile volancy. At the second-order spatial scale, roosting home ranges were associated with woody wetlands farther from anthropogenic development and open water. However, within the third-order scale, northern long-eared bats were associated with undeveloped woody wetlands and upland forests, areas containing shorter trees and occurring proximal to open water. Peripheral and core areas were predicted to comprise approximately 20% of the local landscape. Our results show that complex and large tracts of woody wetlands juxtaposed with upland forests in this part of the Coastal Plain may be important for northern long-eared bats locally, results largely consistent with species management efforts in eastern North America.
Quantitative Risk Assessment of Exposure to Mycobacterium avium subsp. paratuberculosis (MAP) via Different Types of Milk for the Slovenian Consumer
Authors: Knific Tanja , Ocepek Matjaž , Kirbiš Andrej , Krt Branko , Prezelj Jasna , Gethmann Jörn M.
Published: May 2022

This study aimed to assess the risk of exposure to Mycobacterium avium subsp. paratuberculosis (MAP) via milk for the Slovenian consumer. MAP is suspected to be associated with several diseases in humans, therefore the risk of exposure should be better understood. The primary source of MAP for humans is thought to be cattle, in which MAP causes paratuberculosis or Johne’s disease. We developed a stochastic quantitative risk assessment model using Monte Carlo simulations. Considering the assumptions and uncertainties, we estimated the overall risk of exposure to MAP via milk to be low. For people consuming raw milk from MAP positive farms, the risk was high. On-farm pasteurisation reduced the risk considerably, but not completely. The risk of exposure via pasteurised retail milk was most likely insignificant. However, with a higher paratuberculosis prevalence the risk would also increase. Given the popularity of raw milk vending machines and homemade dairy products, this risk should not be ignored. To reduce the risk, consumers should heat raw milk before consumption. To prevent a potential public health scare and safeguard farmers’ livelihoods, a reduction in paratuberculosis prevalence should be sought. Our results show that culling clinically infected cows was insufficient to reduce milk contamination with MAP.
Protective Effect and Mechanism of Soybean Insoluble Dietary Fiber on the Color Stability of Malvidin-3-O-glucoside
Authors: He Yang , Chen Dongxia , Liu Yuheng , Sun Xiaozhen , Guo Wenrui , An Lingyu , Shi Zhenming , Wen Liankui , Wang Zhitong , Yu Hansong
Published: May 2022

Anthocyanins have great health benefits, especially malvidin. Vitis amurensis Rupr are rich in malvidin, and malvidin-3-O-glucoside (Mv3G) monomer is the most abundant. However, natural anthocyanins are unstable, which limits their wide application in the food field. Soybean insoluble dietary fiber (SIDF) has high stability, and it can be used as an inert substrate to construct a stable system, which may improve the stability of anthocyanins. The optimal condition to construct a stable system of SIDF and Mv3G at pH 3.0 was determined by an orthogonal experiment. The results indicated that SIDF effectively improved the stability of Mv3G under different pH values (1.0~7.0), high temperature (100 °C for 100 min), and sunlight (20 ± 2 °C for 30 d) conditions. The absorption peak intensity of the UV–VIS spectrum of SIDF-Mv3G was enhanced, which indicated that there was interaction between SIDF and Mv3G. Fourier transform infrared spectroscopy analyses revealed that the -OH stretching vibration peak of SIDF-Mv3G was changed, which indicated that the interaction between SIDF and Mv3G was due to hydrogen bonding. X-ray diffraction analysis showed that the crystalline morphology of SIDF was opened, which was combined with Mv3G, and SIDF made Mv3G change to a more stable state. Scanning electron microscope analysis showed that SIDF and Mv3G were closely combined to form an inclusion complex. Overall, this study provides valuable information for enhancing the color stability of anthocyanins, which will further expand the application of anthocyanins in the food field.
Microbial Safety and Sensory Analyses of Cold-Smoked Salmon Produced with Sodium-Reduced Mineral Salts and Organic Acid Salts
Authors: Heir Even , Jacobsen Maria , Gaarder Mari Øvrum , Berget Ingunn , Dalgaard Paw , Jensen Merete Rusås , Holck Askild L.
Published: May 2022

Cold-smoked (CS) salmon contains high levels of sodium salts, and excess dietary sodium intake is associated with an array of health complications. CS salmon may also represent a food safety risk due to possible presence and growth of the foodborne pathogen Listeria monocytogenes which may cause fatal human infections. Here we determine how reformulated CS salmon using commercial sodium-reduced salt replacers containing KCl (e.g., Nutek, Smart Salt, SOLO-LITE) and acetate-based preservative salts (Provian K, proviant NDV) affect sensory properties, quality, and microbial safety. Initial sensory screening of sodium-reduced CS salmon was followed by L. monocytogenes growth analyses in selected variants of reformulated CS salmon, and finally by analyses of CS salmon variants produced in an industrial smokehouse. Projective mapping indicated overall minor sensory changes in sodium-replaced samples compared with a conventional product with NaCl. Growth of L. monocytogenes was temperature-dependent (4 °C vs. 8 °C storage) with similar growth in sodium-reduced and conventional CS salmon. The addition of 0.9% of the preservative salts Provian K or Provian NDV gave up to 4 log lower L. monocytogenes counts in both sodium-reduced and conventional cold-smoked salmon after 29 days of chilled storage. No changes in pH (range 6.20–6.33), aw levels (range 0.960–0.973), or weight yield (96.8 ± 0.2%) were evident in CS salmon with salt replacers or Provian preservative salts. Analyses of CS salmon produced with selected mineral salt and preservative salt combinations in an industrial salmon smokery indicated marginal differences in sensory properties. Samples with the preservative salt Provian NDV provided L. monocytogenes growth inhibition and low-level total viable counts (<2.8 log/g) dominated by Photobacterium and Carnobacterium during storage. Production of sodium-reduced CS salmon with inhibiting salts provides a simple method to achieve a healthier food product with increased food safety.
Mutation in Hemagglutinin Antigenic Sites in Influenza A pH1N1 Viruses from 2015–2019 in the United States Mountain West, Europe, and the Northern Hemisphere
Authors: Decker Craig H. , Rapier-Sharman Naomi , Pickett Brett E.
Published: May 2022

H1N1 influenza A virus is a respiratory pathogen that undergoes antigenic shift and antigenic drift to improve viral fitness. Tracking the evolutionary trends of H1N1 aids with the current detection and the future response to new viral strains as they emerge. Here, we characterize antigenic drift events observed in the hemagglutinin (HA) sequence of the pandemic H1N1 lineage from 2015–2019. We observed the substitutions S200P, K147N, and P154S, together with other mutations in structural, functional, and/or epitope regions in 2015–2019 HA protein sequences from the Mountain West region of the United States, the larger United States, Europe, and other Northern Hemisphere countries. We reconstructed multiple phylogenetic trees to track the relationships and spread of these mutations and tested for evidence of selection pressure on HA. We found that the prevalence of amino acid substitutions at positions 147, 154, 159, 200, and 233 significantly changed throughout the studied geographical regions between 2015 and 2019. We also found evidence of coevolution among a subset of these amino acid substitutions. The results from this study could be relevant for future epidemiological tracking and vaccine prediction efforts. Similar analyses in the future could identify additional sequence changes that could affect the pathogenicity and/or infectivity of this virus in its human host.