bluuebunny/crossref_metadata_2025 huggingface dataset:
Antiretrovirals Promote Insulin Resistance in HepG2 Liver Cells through miRNA Regulation and Transcriptional Activation of the NLRP3 Inflammasome
Authors: Mohan Jivanka , Ghazi Terisha , Mazibuko Makabongwe S. , Chuturgoon Anil A.
Published: March 2023

Metabolic syndrome (MetS) is a non-communicable disease characterized by a cluster of metabolic irregularities. Alarmingly, the prevalence of MetS in people living with Human Immunodeficiency Virus (HIV) and antiretroviral (ARV) usage is increasing rapidly. Insulin resistance is a common characteristic of MetS that leads to the development of Type 2 diabetes mellitus (T2DM). The progression of insulin resistance is strongly linked to inflammasome activation. This study aimed to draw links between the combinational use of Tenofovir disoproxil fumarate (TDF), Lamivudine (3TC), and Dolutegravir (DTG), and inflammasome activation and subsequent promotion of insulin resistance following a 120 h treatment period in HepG2 liver in vitro cell model. Furthermore, we assess microRNA (miR-128a) expression as a negative regulator of the IRS1/AKT signaling pathway. The relative expression of phosphorylated IRS1 was determined by Western blot. Transcript levels of NLRP3, IL-1β, JNK, IRS1, AKT, PI3K, and miR-128a were assessed using quantitative PCR (qPCR). Caspase-1 activity was measured using luminometry. Following exposure to ARVs for 120 h, NLRP3 mRNA expression (p = 0.0500) and caspase-1 activity (p < 0.0001) significantly increased. This was followed by a significant elevation in IL-1β in mRNA expression (p = 0.0015). Additionally, JNK expression (p = 0.0093) was upregulated with coinciding increases in p-IRS1 protein expression (p < 0.0001) and decreased IRS1 mRNA expression (p = 0.0004). Consequently, decreased AKT (p = 0.0005) and PI3K expressions (p = 0.0007) were observed. Interestingly miR-128a expression was significantly upregulated. The results indicate that combinational use of ARVs upregulates inflammasome activation and promotes insulin resistance through dysregulation of the IRS1/PI3K/AKT insulin signaling pathway.
Actinomycin-X2-Immobilized Silk Fibroin Film with Enhanced Antimicrobial and Wound Healing Activities
Authors: Zhou Wenjing , Xie Zhenxia , Si Ranran , Chen Zijun , Javeed Ansar , Li Jiaxing , Wu Yang , Han Bingnan
Published: March 2023

Actinomycin is a family of chromogenic lactone peptides that differ in their peptide portions of the molecule. An antimicrobial peptide, actinomycin X2 (Ac.X2), was produced through the fermentation of a Streptomyces cyaneofuscatus strain. Immobilization of Ac.X2 onto a prepared silk fibroin (SF) film was done through a carbodiimide reaction. The physical properties of immobilized Ac.X2 (antimicrobial films, AMFs) were analyzed by ATR-FTIR, SEM, AFM, and WCA. The findings from an in vitro study showed that AMFs had a more broad-spectrum antibacterial activity against both S. aureus and E. coli compared with free Ac.X2, which showed no apparent strong effect against E. coli. These AMFs showed a suitable degradation rate, good hemocompatibility, and reduced cytotoxicity in the biocompatibility assay. The results of in vivo bacterially infected wound healing experiments indicated that wound inflammation was prevented by AMFs, which promoted wound repair and improved the wound microenvironment. This study revealed that Ac.X2 transformation is a potential candidate for skin wound healing.
Radiation Treatment Mechanisms of Cardiotoxicity: A Systematic Review
Authors: Siaravas Konstantinos C. , Katsouras Christos S. , Sioka Chrissa
Published: March 2023

Radiotherapy may be used alone or in combination with chemotherapy for cancer treatment. There are many mechanisms of radiation treatment exposure to toxicities. Our aim was to summarize the literature about known mechanisms of radiation-induced cardiac toxicities. We performed a systematic review of the literature on the PubMed database until October 2022 about cardiovascular toxicities and radiation therapy exposure. Only systematic reviews, meta-analyses, and reviews were selected. Out of 1429 publications screened, 43 papers met inclusion criteria and were selected for the umbrella review process. Microvascular and macrovascular complications could lead to adverse cardiac effects. Many radiotherapy-associated risk factors were responsible, such as the site of radiation treatment, beam proximity to heart tissues, total dosage, the number of radiotherapy sessions, adjuvant chemotherapeutic agents used, and patient traditional cardiovascular risk factors, patient age, and gender. Moreover, important dosage cutoff values could increase the incidence of cardiac toxicities. Finally, the time from radiation exposure to cardiac side effects was assessed. Our report highlighted mechanisms, radiation dosage values, and the timeline of cardiovascular toxicities after radiation therapy. All of the above may be used for the assessment of cardiovascular risk factors and the development of screening programs for cancer patients.
Glial–Neuronal Interactions in Neurological Disorders: Molecular Mechanisms and Potential Points for Intervention
Authors: Adamczyk Agata
Published: March 2023

Neurons have long been central to the study of cellular networks in the nervous system [...]
Novel Aspects Targeting Platelets in Atherosclerotic Cardiovascular Disease—A Translational Perspective
Authors: Huseynov Aydin , Reinhardt Julius , Chandra Leonard , Dürschmied Daniel , Langer Harald F.
Published: March 2023

Platelets are important cellular targets in cardiovascular disease. Based on insights from basic science, translational approaches and clinical studies, a distinguished anti-platelet drug treatment regimen for cardiovascular patients could be established. Furthermore, platelets are increasingly considered as cells mediating effects “beyond thrombosis”, including vascular inflammation, tissue remodeling and healing of vascular and tissue lesions. This review has its focus on the functions and interactions of platelets with potential translational and clinical relevance. The role of platelets for the development of atherosclerosis and therapeutic modalities for primary and secondary prevention of atherosclerotic disease are addressed. Furthermore, novel therapeutic options for inhibiting platelet function and the use of platelets in regenerative medicine are considered.
Sourdough Fermentation Improves the Antioxidant, Antihypertensive, and Anti-Inflammatory Properties of Triticum dicoccum
Authors: Gabriele Morena , Arouna Nafiou , Árvay Július , Longo Vincenzo , Pucci Laura
Published: March 2023

The fermentation process has been widely used to improve plant-based foods’ nutritional and nutraceutical properties. This study aimed to investigate and compare the impact of sourdough fermentation on the bioactive content and profile, antioxidant and antihypertensive activities, as well as the anti-inflammatory properties of fermented (FS) and non-fermented (NFS) flour from Tuscan Triticum dicoccum wheat (spelt) on tumor necrosis factor-alpha (TNF-α)-inflamed human intestinal epithelial cells (HT-29). FS showed significantly higher total phenolic and flavonoid content, in vitro and ex vivo antioxidant activities, and ACE-inhibitory activities than NFS. Gallic acid was identified by HPLC-DAD as the most representative polyphenol, followed by rutin, trans-ferulic acid, iso-quercitrin, and quercetin, in the fermented spelt sample. Instead, rutin and gallic acid were identified as the predominant compounds in the non-fermented ones. Moreover, FS exhibited a better protective effect on inflamed HT-29 cells by significantly counteracting the TNFα-induced alterations, lowering the expression of IL-8, COX-2, and ICAM-1 inflammatory mediator while enhancing antioxidant enzyme HO-1 gene expression. In conclusion, sourdough fermentation positively affected the nutraceutical and functional properties of spelt, which may represent a valuable ingredient for the formulation of functional foods and a key product for managing hypertension and inflammatory intestinal diseases.
Optimising General Configuration of Wing-Sailed Autonomous Sailing Monohulls Using Bayesian Optimisation and Knowledge Transfer
Authors: An Yang , Hu Feng , Chen Kuo , Yu Jiancheng
Published: March 2023

Wing-sailed autonomous sailing monohulls are promising platforms used in various scenarios to provide data for marine science research. These platforms need to operate long-term in changing seas; their general configurations (size matching between sail, hull, and keel) necessitate careful trade-offs to balance safety and efficiency. Since autonomous sailboats are often designed for different observation missions, scientific pay-loads and target areas, their design space is considerably large. It is also challenging to obtain prior performance estimation from historical designs. Therefore, traditional offline surrogate-based simulation-driven design frameworks suffer from a large amount of sampling required, the computational cost of which remains too expensive for such ad hoc design tasks. This paper proposes an innovative, generalised simulation-driven framework combining Bayesian optimisation and knowledge transfer. It allows for high-quality, low-cost optimisation of autonomous sailing monohulls’ general configuration without initial design and prior performance estimation. The proposed optimisation framework has been used to optimise the ‘Seagull’ prototype within the design constraints. The optimised design exhibits significant performance improvements. At the same time, the results show that the present method is significantly superior to traditional offline methods. The authors believe that the proposed framework promises to provide the autonomous sailing community with a solution for a general design methodology.
Ocean Wave Active Compensation Analysis for Redundant Hybrid Boarding System: A Multi-Task Motion Planning Method
Authors: Wang Yueyue , Wei Yanhui , Gao Weihang , Ma Tianyu , Han Yuntao
Published: March 2023

In this paper, to effectively solve the joint motion planning of a nine-DOF redundant hybrid boarding system in the process of ocean wave active compensation, we present a multi-task motion planning (MTMP) method for the redundant hybrid boarding system. First, the hybrid mechanism is disassembled into a six-DOF parallel mechanism and a three-DOF serial mechanism for kinematic analysis separately to obtain the Jacobian matrix of the hybrid mechanism in the task space. Then, according to the configuration characteristics of the hybrid mechanism and to avoid the defects of the pseudo-inverse and weighted pseudo-inverse methods in motion planning, several secondary tasks are proposed to constrain the motion planning of the hybrid mechanism. Based on simulations and comparisons, the results show that the MTMP method solves the problems of joint limitation, reverse compensation, overlap compensation, and divergence with time in the motion planning of the pseudo-inverse method and the weighted pseudo-inverse method. Meanwhile, the MTMP method has more superiority in the joint margin and compensation space range.
Assessment of Shipping Emissions on Busan Port of South Korea
Authors: Kwon Jin-Woo , Yeo Siljung , Lee Won-Ju
Published: March 2023

This study aims to accurately estimate the emissions of seven air pollutants (NOX, SOX, CO2, CO, PM2.5, PM10, and NMVOC) from ships for one year (2020) in the busiest port in Korea, Busan Port. To achieve this, a more detailed method for calculating emissions was developed, taking into account factors such as the type of fuel used, mode of operation, and engine output of each ship that entered and left the port. In cases where information on the ship’s main engine was not available, a regression analysis was performed to estimate the engine output based on the ship’s tonnage. In addition, the output of auxiliary engines was estimated based on the ratio of the output of the main engine to that of the auxiliary engine for recently built ships. Finally, emissions from fishing vessels were also included in the calculations. Thus, in Busan port, the total estimated fuel consumption from 44,315 cases in 2020 was 252,519 t; the consumption during hoteling accounted for 87%. In detail, the emissions of seven air pollutants reflecting the emission factors were analyzed as follows: NOX, 18,323 t; SOX, 16,924 t; CO2, 790.383 t; CO, 714 t; PM2.5, 1484 t, PM10, 1614 t; and NMVOC, 772 t. In addition, this study provides an estimation equation to estimate engine output based on a ship’s tonnage, which showed the highest fitness when compared to actual engine output. This methodology can be useful for calculating emissions of air pollutants at the port in detail and promoting marine environment policies.
Effect of Hydrodynamic Condition on Adsorption of Sulfadiazine on Marine Sediments
Authors: Xu Wei , Xu Jiaxin , Song Jie , Xiu Guangli
Published: March 2023

In the present study, the adsorption behavior of sulfadiazine (SDZ) on various sediments under different hydrodynamic conditions generated by a rocking shaker was investigated. Based on the dye mixing experiments, three regimes with different hydrodynamic characteristics, i.e., laminar, transition, and turbulent regimes, were identified. The hydrodynamic intensity was found to have a positive effect on the adsorption of SDZ, In general, the adsorption capacity followed the order of turbulent > transition > laminar > static. Compared to quartz sands, montmorillonite exhibited a narrower range of adsorption capacity under different hydrodynamic conditions, which implies it is less sensitive to the hydrodynamic conditions. For adsorption kinetics, sands fit the pseudo-first-order model, while montmorillonite fits the pseudo-second-order model. For adsorption thermodynamics, the Freundlich model showed a better correlation coefficient for all sediments. In addition, it was found that particle size could affect the antibiotic adsorption capacity, and the presence of salts inhibited the adsorption performance.
Microplastic Accumulation in Catfish and Its Effects on Fish Eggs from Songkhla Lagoon, Thailand
Authors: Pradit Siriporn , Noppradit Prakrit , Jitkaew Preyanuch , Sengloyluan Karnda , Yucharoen Mathinee , Suwanno Phudith , Tanrattanakul Varaporn , Sornplang Kittiwara , Nitiratsuwan Thongchai
Published: March 2023

Microplastics have been found to accumulate in freshwater, marine ecosystems, and biological organisms. The frequency of studies on microplastic contamination in organs has increased recently, although there have been relatively fewer investigations on fish eggs in Thailand. To extract microplastics from catfish samples for laboratory analysis (Osteogeneiosus militaris), we used 10% potassium hydroxide in the digestion process. A needle penetrated the fish eggs to investigate microplastic contamination. We examined microplastics under a stereomicroscope and used Fourier transform infrared spectroscopy to determine the type of polymer. We found microplastic contamination in organs, most commonly in the stomach (0.91 ± 0.13 items/g), followed by tissue (0.53 ± 0.09 items/g), and gills (0.30 ± 0.03 items/g) at the level of significance p < 0.01. We found a total of 349 fish eggs with 27 items of microplastic. The dominant microplastic we found in the stomach, tissue, and gills of the fish, as well as in fish eggs, was of fiber shape. We noted that fragments were found only in the stomach and tissue of fish. The dominant color of microplastics was black in organs and blue in fish eggs. The common polymer types in organs and fish eggs were polyethylene terephthalate, polypropylene, and cellulosic fiber.
Incidence of Pneumocystis Pneumonia in Immunocompromised Patients without Human Immunodeficiency Virus on Intravenous Pentamidine Prophylaxis: A Systematic Review and Meta-Analysis
Authors: Chiu Chia-Yu , Ching Patrick R.
Published: March 2023

Background: Trimethoprim-sulfamethoxazole (TMP-SMX) is a first-line Pneumocystis pneumonia (PCP) prophylaxis agent, but monthly intravenous pentamidine (IVP) is used in immunocompromised hosts without human immunodeficiency virus (HIV) infection because IVP is not associated with cytopenia and delayed engraftment. Method: We performed a systematic review and meta-analysis to estimate breakthrough PCP incidence and adverse reactions in HIV-uninfected immunocompromised patients receiving IVP. MEDLINE, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov were searched from their inception until 15 December 2022. Results: The pooled incidence of breakthrough PCP with IVP was 0.7% (95% CI, 0.3–1.4%, 16 studies, 3025 patients) and was similar when used as first-line prophylaxis (0.5%; 95% CI, 0.2–1.4%, 7 studies, 752 patients). The pooled incidence of adverse reactions was 11.3% (95% CI, 6.7–18.6%, 14 studies, 2068 patients). The pooled adverse event-related discontinuation was 3.7% (95% CI, 1.8–7.3%, 11 studies, 1802 patients), but was lower in patients receiving IVP monthly (2.0%; 95% CI 0.7–5.7%, 7 studies, 1182 patients). Conclusion: Monthly IVP is an appropriate second-line agent for PCP prophylaxis in certain non-HIV immunocompromised hosts, especially in patients with hematologic malignancies and hematopoietic stem cell transplant recipients. Using IVP for PCP prophylaxis as an alternative to oral TMP-SMX while patients are unable to tolerate enteral medication administration is feasible.
Patient Specific Implants for Orbital Reconstruction in the Treatment of Silent Sinus Syndrome: Two Case Reports
Authors: Raveggi Elisa , Sobrero Federica , Gerbino Giovanni
Published: March 2023

Silent sinus syndrome is a rare disorder characterized by ipsilateral enophthalmos and hypoglobus following a collapse of the orbital floor, in the presence of asymptomatic long-term maxillary sinusitis. It results in enophthalmos, hypoglobus and deepening of the superior palpebral sulcus. A standardized treatment protocol for this infrequent syndrome has not yet been established. The management includes restoration of maxillary sinus ventilation with functional endoscopic sinus surgery and orbital reconstruction, either concurrently or separately. In this paper, the authors presented two patients successfully treated with patient-specific implants, and intraoperative navigation. These cases highlight the benefit of computer-assisted planning and titanium patient-specific implants in the management of silent sinus syndrome. To the best of our knowledge, this is the first report that described the use of PSI with titanium spacers performed with the aid of intraoperative navigation for SSS treatment. Advantages, drawbacks of this technique and treatment alternatives currently available in the literature were also discussed.
Fast Degradation of Rhodamine B by In Situ H2O2 Fenton System with Co and N Co-Doped Carbon Nanotubes
Authors: Cui Wei , Fang Jiahui , Wan Yuanyuan , Tao Xueyu , Guo Litong , Feng Qiyan
Published: March 2023

In this study, an E-fenton oxidation system based on Co-N co-doped carbon nanotubes (Co-N-CNTs) was designed. The Co-N-CNTs system showed fast degradation efficiency and reusability for the degradation of rhodamine B (RhB). The XRD and SEM results showed that the Co-N co-doped carbon nanotubes with diameters ranging from 40 to 400 nm were successfully prepared. The E-Fenton degradation performance of Co-N-CNTs was investigated via CV, LSV and AC impedance spectroscopy. The yield of H2O2 could reach 80 mg/L/h within 60 min, and the optimal voltage and preparation temperature for H2O2 yield in this system was −0.7 V (vs. SCE) and 800 °C. For the target pollutant of RhB, the fast removal of RhB was obtained via the Co-N-CNTS/E-Fenton system (about 91% RhB degradation occurred during 60 min), and the •OH played a major role in the RhB degradation. When the Fe2+ concentrations increased from 0.3 to 0.4 mM, the RhB degradation efficiency decreased from 91% to about 87%. The valence state of Co in the Co-N-C catalyst drove a Co2+/Co3+ cycle, which ensured the catalyst had good E-Fenton degradation efficiency. This work provides new insight into the mechanism of an E-Fenton system with carbon-based catalysts for the efficient degradation of RhB.
CO2 Methanation: Solvent-Free Synthesis of Nickel-Containing Catalysts from Complexes with Ethylenediamine
Authors: Netskina Olga V. , Dmitruk Kirill A. , Mazina Olga I. , Paletsky Alexander A. , Mukha Svetlana A. , Prosvirin Igor P. , Pochtar Alena A. , Bulavchenko Olga A. , Shmakov Andrey G. , Veselovskaya Janna V. , Komova Oxana V.
Published: March 2023

CO2 methanation was studied in the presence of nickel catalysts obtained by the solid-state combustion method. Complexes with a varying number of ethylenediamine molecules in the coordination sphere of nickel were chosen as the precursors of the active component of the catalysts. Their synthesis was carried out without the use of solvents, which made it possible to avoid the stages of their separation from the solution and the utilization of waste liquids. The composition and structure of the synthesized complexes were confirmed by elemental analysis, IR spectroscopy, powder XRD and XPS methods. It was determined that their thermal decomposition in the combustion wave proceeds in multiple stages with the formation of NiO and Ni(OH)2, which are reduced to Ni0. Higher ethylenediamine content in the complex leads to a higher content of metal in the solid products of combustion. However, different ratios of oxidized and reduced forms of nickel do not affect the initial activation temperature of nickel catalysts in the presence of CO2. It was noted that, after activation, the sample obtained from [Ni(C2H8N2)2](NO3)2 exhibited the highest activity in CO2 methanation. Thus, this complex is a promising precursor for CO2 methanation catalysts, and its synthesis requires only a small amount of ethylenediamine.
Material Evidence of Sediments Recovered from Ancient Amphorae Found at the Potaissa Roman Fortress
Authors: Farcas Iulia Alexandra , Dippong Thomas , Petean Ioan , Moldovan Marioara , Filip Miuta Rafila , Ciotlaus Irina , Tudoran Lucian Barbu , Borodi Gheorghe , Paltinean Gertrud Alexandra , Pripon Emanoil , Bunea Claudiu Ioan
Published: March 2023

Methods for material investigation are powerful tools that allow specialists to elucidate important aspects regarding ancient artifacts such as the Roman amphorae deposits discovered at Potaissa Fortress in Turda, Romania. Archeological debate states that the deposit contained olive oil and wine amphorae, but no material evidence has been presented until now. The current research is focused on the most representative large amphora fragments found in the Potaissa deposit, with a significant amount of sediment on their walls, to give archeologists the material proof to elucidate their debate. Sediment was collected from each fragment and subjected to complex analysis. XRD investigation combined with cross-polarized light microscopy demonstrated mineral particles such as quartz, clay (muscovite and traces of biotite), and calcite. Quartz and calcite particles have a rounded shape and diameters in a range of 20–200 µm, and clay particles have a lamellar shape and dimensions from 1 to 20 µm, a fact confirmed by SEM microscopy. Sample 2 presented a large amount of amorphous phase followed by Samples 1 and 3, with a low amount of organic phase. FTIR investigation confirms organic phase presence owing to strong absorption bands regarding C-H, C=O, and O-H chemical bonds related to aliphatic compounds in Sample 2, and to some decayed wine residue in Samples 1 and 3. EDS elemental analysis was used for organic particle identification in the amphora sediments and to obtain a correlation with their microstructure. GC–MS investigation showed volatile compounds related to wine residue for Samples 1 and 3 and decomposed fats for Sample 2. Tartaric and malic acid were identified by HPLC in Samples 1 and 3, which are wine biomarkers. The correlation of all experimental results concludes with no doubt that Amphora 2 contained olive oil and Amphorae 1 and 3 contained wine in ancient times.
Analytical and Numerical Investigation of Nanowire Transistor X-ray Detector
Authors: Ellakany Abdelhady , Zekry Abdelhalim , Abouelatta Mohamed , Shaker Ahmed , Sayah Gihan T. , El-Banna Mohamed M.
Published: March 2023

Recently, nanowire detectors have been attracting increasing interest thanks to their advantages of high resolution and gain. The potential of using nanowire detectors is investigated in this work by developing a physically based model for Indium Phosphide (InP) phototransistor as well as by performing TCAD simulations. The model is based on solving the basic semiconductor equations for bipolar transistors and considering the effects of charge distribution on the bulk and on the surface. The developed model also takes into consideration the impact of surface traps, which are induced by photogenerated carriers situated at the surface of the nanowire. Further, photogating phenomena and photodoping are also included. Moreover, displacement damage (DD) is also investigated; an issue arises when the detector is exposed to repeated doses. The presented analytical model can predict the current produced from the incident X-ray beam at various energies. The calculation of the gain of the presented nanowire carefully considers the different governing effects at several values of energies as well as biasing voltage and doping. The proposed model is built in MATLAB, and the validity check of the model results is achieved using SILVACO TCAD device simulation. Comparisons between the proposed model results and SILVACO TCAD device simulation are provided and show good agreement.
Three-Species Predator–Prey Stochastic Delayed Model Driven by Lévy Jumps and with Cooperation among Prey Species
Authors: Danane Jaouad , Torres Delfim F. M.
Published: March 2023

Our study focuses on analyzing the behavior of a stochastic predator–prey model with a time delay and logistic growth of prey, influenced by Lévy noise. Initially, we establish the existence, uniqueness, and boundedness of a positive solution that spans globally. Subsequently, we explore the conditions under which extinction occurs, and identify adequate criteria for persistence. Finally, we validate our theoretical findings through numerical simulations, which also helps illustrate the dynamics of the stochastic delayed predator–prey model based on different criteria.
DESnets: A Graphical Representation for Discrete Event Simulation and Cost-Effectiveness Analysis
Authors: Yago Carmen María , Díez Francisco Javier
Published: March 2023

Cost-effectiveness analysis (CEA) is used increasingly in medicine to determine whether the health benefit of an intervention is worth the economic cost. Discrete event simulation (DES) is playing an increasing role in CEA thanks to several advantages, such as the possibility of modeling time and heterogeneous populations. It is usually implemented with general-purpose programming languages or commercial software packages. To our knowledge, no artificial intelligence technique has been applied to DES for CEA. Our objective is to develop a graphical representation, an algorithm, and a software tool that allows non-programmers to easily build models and perform CEA. We present DESnets (discrete event simulation networks) as a new type of probabilistic graphical model inspired by probabilistic influence diagrams, an algorithm for evaluating and an implementation as an OpenMarkov plug-in. DESnets are compared qualitatively and empirically with six alternative tools using as a running example a model about osteoporosis by the British National Institute for Health and Care Excellence (NICE). In our experiments, the implementation of DESnets allowed the building of a typical DES model declaratively. Its evaluation process ranked among the most efficient. DESnets compare favorably with alternative tools in terms of ease of use, expressive power, transparency, and computational efficiency.
From Zeroing Dynamics to Zeroing-Gradient Dynamics for Solving Tracking Control Problem of Robot Manipulator Dynamic System with Linear Output or Nonlinear Output
Authors: Zheng Zheng , Zeng Delu
Published: March 2023

With the vigorous development of mechanical intelligence in industrial manufacturing, tracking control dynamic systems have been widely applied in many aspects of industry. In this paper, we present one theorem to discuss the validity condition of a ZD model with order-n for solving the tracking control problem of a nonlinear problem by utilizing a Lie derivative. Moreover, we also give the unified formula of the ZD model with order-n and rigorously prove it mathematically. In addition, we present three other theorems to give the global exponential convergence property of the ZD controller u(t), and the steady-state tracking error bound of the ZGD controller u(t), and the radius bound where the steady-state tracking error converges exponentially. Finally, simulations are conducted to demonstrate the validity and parameter influences of the ZD model and ZGD model for solving the tracking control problem with a single linear or nonlinear output of the single-link manipulator with flexible joints.
A Generalized Finite Difference Scheme for Multiphase Flow
Authors: Joubert Johannes C. , Wilke Daniel N. , Pizette Patrick
Published: March 2023

This paper presents a GPU-based, incompressible, multiphase generalized finite difference solver for simulating multiphase flow. The method includes a dampening scheme that allows for large density ratio cases to be simulated. Two verification studies are performed by simulating the relaxation of a square droplet surrounded by a light fluid and a bubble rising in a denser fluid. The scheme is also used to simulate the collision of binary droplets at moderate Reynolds numbers (250–550). The effects of the surface tension and density ratio are explored in this work by considering cases with Weber numbers of 8 and 180 and density ratios of 2:1 and 1000:1. The robustness of the multiphase scheme is highlighted when resolving thin fluid structures arising in both high and low density ratio cases at We = 180.
Jellyfishes—Significant Marine Resources with Potential in the Wound-Healing Process: A Review
Authors: Cadar Emin , Pesterau Ana-Maria , Sirbu Rodica , Negreanu-Pirjol Bogdan Stefan , Tomescu Cezar Laurentiu
Published: March 2023

The wound-healing process is a significant area of interest in the medical field, and it is influenced by both external and patient-specific factors. The aim of this review paper is to highlight the proven wound-healing potential of the biocompounds found in jellyfish (such as polysaccharide compounds, collagen, collagen peptides and amino acids). There are aspects of the wound-healing process that can benefit from polysaccharides (JSPs) and collagen-based materials, as these materials have been shown to limit exposure to bacteria and promote tissue regeneration. A second demonstrated benefit of jellyfish-derived biocompounds is their immunostimulatory effects on growth factors such as (TNF-α), (IFN-γ) and (TGF), which are involved in wound healing. A third benefit of collagens and polysaccharides (JSP) is their antioxidant action. Aspects related to chronic wound care are specifically addressed, and within this general theme, molecular pathways related to tissue regeneration are explored in depth. Only distinct varieties of jellyfish that are specifically enriched in the biocompounds involved in these pathways and live in European marine habitats are presented. The advantages of jellyfish collagens over mammalian collagens are highlighted by the fact that jellyfish collagens are not considered transmitters of diseases (spongiform encephalopathy) or various allergic reactions. Jellyfish collagen extracts stimulate an immune response in vivo without inducing allergic complications. More studies are needed to explore more varieties of jellyfish that can be exploited for their biocomponents, which may be useful in wound healing.
Releasing Bioactive Compounds from Brown Seaweed with Novel Cold-Adapted Alginate Lyase and Alcalase
Authors: Jiang Jun , Jiang Zhengqiang , Yan Qiaojuan , Han Susu , Yang Shaoqing
Published: March 2023

Seaweeds are considered to be third-generation renewable biomasses, the comprehensive utilization of which has drawn increasing attention in recent years. A novel cold-active alginate lyase (VfAly7) was identified from Vibrio fortis and biochemically characterized for brown seaweed utilization. The alginate lyase gene was high-level expressed in Pichia pastoris, with an enzyme yield of 560 U/mL and a protein content of 9.8 mg/mL by high-cell density fermentation. The recombinant enzyme was most active at 30 °C and pH 7.5, respectively. VfAly7 was a bifunctional alginate lyase with both poly-guluronate and poly-mannuronate hydrolysis activities. On the basis of VfAly7, a bioconversion strategy for the utilization of brown seaweed (Undaria pinnatifida) was developed. The obtained AOSs showed stronger prebiotic activity towards tested probiotics when compared to that of commercial fructooligosaccharides (FOSs), while the obtained protein hydrolysates displayed strong xanthine oxidase inhibitory activity with IC50 of 3.3 mg/mL. This study provided a novel alginate lyase tool as well as a biotransformation route for the utilization of seaweeds.
Understanding the Residence Time Distribution in a Transient Inline Spiking System: Modeling, Experiments, and Simulations
Authors: Hwang Minsun , Wang Junsuk , Jung Seon Yeop
Published: March 2023

A transient inline spiking system is a promising tool for evaluating the performance of a virus filter in continuous operation. For better implementation of the system, we performed a systematic analysis to understand the residence time distribution (RTD) of inert tracers in the system. We aimed to understand the RTD of a salt spike, not retained onto or within the membrane pore, to focus on its mixing and spreading within the processing units. A concentrated NaCl solution was spiked into a feed stream as the spiking duration (tspike) was varied from 1 to 40 min. A static mixer was employed to mix the salt spike with the feed stream, which then passed through a single-layered nylon membrane inserted in a filter holder. The RTD curve was obtained by measuring the conductivity of the collected samples. An analytical model, the PFR-2CSTR model, was employed to predict the outlet concentration from the system. The slope and peak of the RTD curves were well-aligned with the experimental findings when τPFR = 4.3 min, τCSTR1 = 4.1 min, and τCSTR2 = 1.0 min. CFD simulations were performed to describe the flow and transport of the inert tracers through the static mixer and the membrane filter. The RTD curve spanned more than 30 min, much longer than tspike, since solutes were dispersed within processing units. The flow characteristics in each processing unit correlated with the RTD curves. Our detailed analysis of the transient inline spiking system would be helpful for implementing this protocol in continuous bioprocessing.
Forward Osmosis Membrane: Review of Fabrication, Modification, Challenges and Potential
Authors: Ibraheem Bakr M. , Aani Saif Al , Alsarayreh Alanood A. , Alsalhy Qusay F. , Salih Issam K.
Published: March 2023

Forward osmosis (FO) is a low-energy treatment process driven by osmosis to induce the separation of water from dissolved solutes/foulants through the membrane in hydraulic pressure absence while retaining all of these materials on the other side. All these advantages make it an alternative process to reduce the disadvantages of traditional desalination processes. However, several critical fundamentals still require more attention for understanding them, most notably the synthesis of novel membranes that offer a support layer with high flux and an active layer with high water permeability and solute rejection from both solutions at the same time, and a novel draw solution which provides low solute flux, high water flux, and easy regeneration. This work reviews the fundamentals controlling the FO process performance such as the role of the active layer and substrate and advances in the modification of FO membranes utilizing nanomaterials. Then, other aspects that affect the performance of FO are further summarized, including types of draw solutions and the role of operating conditions. Finally, challenges associated with the FO process, such as concentration polarization (CP), membrane fouling, and reverse solute diffusion (RSD) were analyzed by defining their causes and how to mitigate them. Moreover, factors affecting the energy consumption of the FO system were discussed and compared with reverse osmosis (RO). This review will provide in-depth details about FO technology, the issues it faces, and potential solutions to those issues to help the scientific researcher facilitate a full understanding of FO technology.
Atomistic-Continuum Constitutive Modeling Connection for Gold Foams under Compression at High Strain Rates: The Dislocation Density Effect
Authors: Saffarini Mohammed H. , Voyiadjis George Z.
Published: March 2023

Constitutive description of the plastic flow in metallic foams has been rarely explored in the literature. Even though the material is of great interest to researchers, its plasticity remains a topic that has a much room for exploration. With the help of the rich literature that explored the material deformation mechanism, it is possible to introduce a connection between the results of the atomistic simulations and the well-established continuum constitutive models that were developed for various loading scenarios. In this work, we perform large-scale atomistic simulations of metallic gold foams of two different sizes at a wide range of strain rates (107−109 s−1) under uniaxial compression. By utilizing the results of those simulations, as well as the results we reported in our previous works, a physical atomistic-continuum dislocations-based constitutive modeling connection is proposed to capture the compressive plastic flow in gold foams for a wide range of sizes, strain rates, temperatures, and porosities. The results reported in this work present curated datasets that can be of extreme usefulness for the data-driven AI design of metallic foams with tunable nanoscale properties. Eventually, we aim to produce an optimal physical description to improve integrated physics-based and AI-enabled design, manufacture, and validation of hierarchical architected metallic foams that deliver tailored mechanical responses and precision failure patterns at different scales.
Study of Metal Leaching from Printed Circuit Boards by Improved Electrochemical Hydrochlorination Technique Using Alternating Current
Authors: Serga Vera , Zarkov Aleksej , Shishkin Andrei , Elsts Edgars , Melnichuks Maksims , Maiorov Mikhail , Blumbergs Ervins , Pankratov Vladimir
Published: March 2023

This paper presents the results of the leaching of metals from computer PCBs by electrochemical hydrochlorination using alternating current (AC) with an industrial frequency (50 Hz). Leaching was carried out with a disintegrator-crushed computer motherboard with a particle size (d) of <90 μm. In the course of the research, the leaching efficiency of metals including Fe, Sn, Mn, Al, Cu, Zn, Pb, Ni, Ti, Sb, Cr, Co and V was evaluated depending on process parameters, such as AC density, experiment duration, hydrochloric acid concentration in the electrolyte solution, solid/liquid ratio, electrolyte temperature, and the loading option of raw material (loading option 1 involving loading into the electrolyte solution, and loading option 2 involving loading into the filter containers attached to electrodes). The research results showed that AC superimposition significantly intensifies the leaching of metals. It was established that the complete leaching of metals including Al, Mn, Sn, Ti and Zn, under experimental conditions (loading option 2, CHCl = 6 mol·L−1, i = 0.80 A·cm−2, S/L = 8.6 g·L−1), is reached after 1.5 h, and that of Cu and Ni is reached after 2 h from the beginning of the experiment. At the same time, the degree of leaching of other metals after 2 h is Co-78.8%, Cr-84.4%, Sb-91.7%, Fe-98.9%, V-98.1% and Pb-5.1%. The paper also reports the results on the leaching of all abovementioned metals, as well as Ag and Pd, with disintegrator-crushed mixed computer PCBs with d < 90 μm and loading option 1.
Experimental Study on the Dynamic Behavior of a Cr-Ni-Mo-V Steel under Different Shock Stresses
Authors: Zhao Xinyi , Li Hongjun
Published: March 2023

The present study aimed to provide new insights into the behavior of high-strength low-alloy steel under dynamic compression and to promote its use in high-stress applications. The dynamic compression response of a Cr-Ni-Mo-V steel under shock stresses ranging from 3.54 GPa to 19.76 GPa was investigated using loading technology. The free surface velocity of the specimen was measured using a displacement interferometer system with the range of 166–945 m/s. The Hugoniot elastic limit (HEL), spalling fracture, and microstructure evolution of specimens under different shock stresses were determined. The results showed that an α→ε phase transition occurred in the material at an impact stress of 15.63 GPa, leading to a change in particle velocity. The relationship between the shock wave velocity and particle velocity was found to be linear. The HEL of the steel was found to be consistent at 2.28 GPa, while the spall strength showed a more complex relationship with the increasing shock stress. Initially, the spall strength increased and then decreased with increasing shock stress before increasing again after the phase transformation. The fracture mode of the steel shifted from brittle fracture to ductile fracture with the increasing impact stresses, which is related to the previous plastic deformation under different impact loads.
Current Understanding of Flavonoids in Cancer Therapy and Prevention
Authors: Farhan Mohd , Rizvi Asim , Aatif Mohammad , Ahmad Aamir
Published: March 2023

Cancer is a major cause of death worldwide, with multiple pathophysiological manifestations. In particular, genetic abnormalities, inflammation, bad eating habits, radiation exposure, work stress, and toxin consumption have been linked to cancer disease development and progression. Recently, natural bioactive chemicals known as polyphenols found in plants were shown to have anticancer capabilities, destroying altered or malignant cells without harming normal cells. Flavonoids have demonstrated antioxidant, antiviral, anticancer, and anti-inflammatory effects. Flavonoid type, bioavailability, and possible method of action determine these biological actions. These low-cost pharmaceutical components have significant biological activities and are beneficial for several chronic disorders, including cancer. Recent research has focused primarily on isolating, synthesizing, and studying the effects of flavonoids on human health. Here we have attempted to summarize our current knowledge of flavonoids, focusing on their mode of action to better understand their effects on cancer.
Research on Robotic Compliance Control for Ultrasonic Strengthening of Aviation Blade Surface
Authors: Fang Shanxiang , Du Yao , Zhang Yong , Meng Fanbo , Ang Marcelo H.
Published: March 2023

In order to satisfy the requirement of the automatic ultrasonic strengthening of an aviation blade surface, this paper puts forward a robotic compliance control strategy of contact force for ultrasonic surface strengthening. By building the force/position control method for robotic ultrasonic surface strengthening., the compliant output of the contact force is achieved by using the robot’s end-effector (compliant force control device). Based on the control model of the end-effector obtained from experimental determination, a fuzzy neural network PID control is used to optimize the compliance control system, which improves the adjustment accuracy and tracking performance of the system. An experimental platform is built to verify the effectiveness and feasibility of the compliance control strategy for the robotic ultrasonic strengthening of an aviation blade surface. The results demonstrate that the proposed method maintains the compliant contact between the ultrasonic strengthening tool and the blade surface under multi-impact and vibration conditions.
Review of Microbottle Resonators for Sensing Applications
Authors: Adnan Zain Huda , Batumalay Malathy , Haris Hazlihan , Saad Ismail , Muhammad Ahmad Razif , Mustaffa Siti Nasuha , Markom Arni Munira , Abdul Rahim Hazli Rafis , Tan Sin Jin , Harun Sulaiman Wadi
Published: March 2023

Microbottle resonators (MBR) are bottle-like structures fabricated by varying the radius of an optical fiber. MBRs can support whispering gallery modes (WGM) by the total internal reflection of the light coupled into the MBRs. MBRs have a significant advantage in sensing and other advanced optical applications due to their light confinement abilities in a relatively small mode volume and having high Q factors. This review starts with an introduction to MBRs’ optical properties, coupling methods, and sensing mechanisms. The sensing principle and sensing parameters of MBRs are discussed here as well. Then, practical MBRs fabrication methods and sensing applications are presented.
Performance Study of Piezoelectric Injection System Based on Finite Element Simulation
Authors: Li Xin , Zhao Yongsheng
Published: March 2023

This paper presents a performance prediction method for piezoelectric injection systems, based on finite element simulations. Two indexes representing the system performance are proposed: jetting velocity and droplet diameter. By combining Taguchi’s orthogonal array method and finite element simulation (FES), a finite element model of the droplet injection process, with different parameter combinations, was established. The two performance indexes, jetting velocity and droplet diameter, were accurately predicted, and their variation with time were investigated. Finally, the accuracy of the predicted results of the FES model was verified by experiments. The errors of the predicted jetting velocity and droplet diameter were 3.02% and 2.20%, respectively. It is verified that the proposed method has better reliability and robustness than the traditional method.
A Design Approach to Reducing Stress and Distortion Caused by Adhesive Assembly in Micromachined Deformable Mirrors
Authors: Man Wenkuan , Bifano Thomas G.
Published: March 2023

A common problem in deformable mirror assembly is that the adhesion of actuators to an optical mirror face sheet introduces unwanted topography due to large local stresses generated at the adhesive joint. A new approach to minimizing that effect is described, with inspiration taken from St. Venant’s principle, a fundamental precept in solid mechanics. It is demonstrated that moving the adhesive joint to the end of a slender post extending from the face sheet largely eliminates deformation due to adhesive stresses. A practical implementation of this design innovation is described, using silicon-on-insulator wafers and deep reactive ion etching. Simulation and experiments validate the effectiveness of the approach, reducing stress-induced topography on a test structure by a factor of 50. A prototype electromagnetic DM using this design approach is described, and its actuation is demonstrated. This new design can benefit a wide range of DMs that rely on actuator arrays that are adhesively bonded to a mirror face sheet.