bluuebunny/crossref_metadata_2025 huggingface dataset:
Tranformação, diálogos e linguagem sobre as mudanças climáticas
Authors: Petraglia Izabel Cristina , Pena-Vega Alfredo , Arone Mariangelica , Fernandes Marcel Sena , Fernandes Conceição Aparecida Viude
Published: January 2020

Este artigo apresenta resultados parciais da pesquisa internacional em desenvolvimento intitulada “Pacto Mundial de jovens pelo clima” (em inglês: Global Youth Climate Pact) e um recorte, que se realiza no Brasil: “Mudanças climáticas na visão de estudantes de ensino médio, no Brasil”, em que promovemos diálogos e reflexões em relação à evolução das mudanças climáticas e ao compromisso necessário com o meio ambiente e com a cidadania planetária. Trata-se de um estudo em nível global e local que está nos possibilitando, no conjunto dos resultados parciais obtidos até o presente, perceber os valores, os sonhos e os comportamentos dos jovens para uma sociedade sustentável. Apresentamos, aqui, um recorte que aborda a conclusão da primeira fase da pesquisa, realizada em 2014 e 2015, com base nas investigações continuadas, sistematizações e divulgação de resultados que foram encaminhadas à COP21, em Paris, embora as suas propostas tenham também convergência com os encaminhamentos dos jovens de outros países participantes. Acreditamos ser importante conhecer como os jovens de diferentes regiões e diversificadas culturas sentem a magnitude das mudanças climáticas e a sua evolução, já que serão eles os gestores do Planeta, daqui a alguns anos. São essas prerrogativas e questões, cujas respostas estamos perseguindo, que justificam a relevância social e acadêmica desta pesquisa. O referencial teórico norteador é a epistemologia da complexidade, de Edgar Morin, e a pesquisa de abordagem inter e transdisciplinar adota técnicas multidisciplinares, tais como observação, entrevistas com gestores, grupos focais com estudantes, discussão cidadã entre os jovens (crowdsourcing).
Composteira Pedagógica: uma proposta de material didático para abordagem da temática "Vermicompostagem" no ensino de Química
Authors: Costa Denise Gomes da Silva , De Aguiar Paula Alves
Published: January 2020

Este texto apresenta um relato de experiência da prática de estágio curricular supervisionado do curso de Licenciatura em Química do IFSC/SJ em uma turma do Ensino Médio. A experiência em questão trata-se da elaboração e do desenvolvimento do projeto “Vermicompostagem na escola: Construção do conhecimento e sustentabilidade visando à valorização da comunidade escolar", cujas principais etapas são descritas, no intuito de trazer ao(à) leitor(a) as relações processuais inerentes à realização do mesmo. De outra parte, neste trabalho também se buscou evidenciar o processo de elaboração e desenvolvimento de um material didático, como mediador pedagógico entre o(a) aluno(a) e o conhecimento. Desta forma, o objetivo principal deste texto é apresentar a composteira pedagógica utilizada para abordagem da temática “Vermicompostagem” no ensino de Química, identificando suas contribuições para o alcance de aprendizagens mais significativas de acordo com os pressupostos assumidos na elaboração o projeto em questão, dentre os quais estão os dos Projetos Criativos Ecoformadores. Considerações sobre a experiência também são feitas a partir do relato de percepções subjetivas dos momentos da interação teórica e prática proporcionados pela mediação da composteira pedagógica; bem como por meio da apresentação de dados elencados de dois questionários aplicados durante a regência. A partir disso, evidencia-se que a proposta e o recurso didático trabalhado proporcionaram um processo de ensino-aprendizagem significativo e prazeroso. Nas relações entre os sujeitos, houve indícios de que os(as) alunos(as) se mostraram motivados(as) e protagonistas no processo educativo.
Construção de um currículo transdisciplinar para a educação superior
Authors: Viegas Josgrilbert Maria de Fátima , Suanno João Henrique
Published: January 2020

A finalidade deste texto é narrar uma iniciativa didático-pedagógica de construção de um design curricular dos cursos superiores de uma faculdade, sob o enfoque transdisciplinar. O que fazer primeiro: modificar o projeto ou a atitude dos professores? Para responder esta questão e acompanhar a ação pedagógica, foi desenvolvida uma pesquisa qualitativa do tipo: grupo focal. Outras questões também precisaram ser repensadas, como: a importância do curso para a região, a clientela, a equipe de professores, o espaço físico, o foco do curso; tendo como base a missão da instituição. Um currículo inter/transdisciplinar favorece a articulação entre os conteúdos científicos e os conteúdos da vida humana, resultando em um compromisso social da instituição na formação de um egresso que busque a concretização da cidadania, bem como a construção de uma sociedade mais justa. O exercício de repensar o curso, também foi modificando o pensar dos docentes.
Legislación estatal sobre los usos del agua en México: Una comparación entre los casos de Jalisco y Oaxaca, 1895-1905
Authors: Topete Pozas Olivia , Mendez Zárate Armando
Published: January 2020

Este trabajo lleva a cabo un análisis comparativo de la proyección y aplicación legislativa sobre los usos del agua en los estados mexicanos de Jalisco y Oaxaca. Especialmente, después la instrumentalización del Decreto Número 696 de Jalisco del 19 de septiembre de 1895 y la Ley sobre el uso y aprovechamiento de las aguas de Oaxaca del 28 de enero de 1905. Ambos instrumentos jurídicos supusieron una estrategia legal de los estados, ayuntamientos y municipios frente a los intentos del gobierno federal por controlar las concesiones y jurisdicción del agua en el territorio mexicano. De esta forma, subrayaremos las diferencias de las acciones emprendidas por los gobiernos estatales y locales frente a un proceso nacional que buscó nacionalizar y controlar las corrientes de agua en los estados.
DEVELOPMENT OF A PLANNING DECISION OF PEDESTRIAN COMMUNICATION FRAME IN TRANSPORT HUBS TAKING INTO ACCOUNT THE ORGANIZATION OF THE MOVEMENT OF PEOPLE WITH LIMITED MOBILITY
Authors: DANILINA Nina V. , PRIVEZENTSEVA Svetlana V.
Published: January 2020

The methodological scheme of the sequence of actions and the implementation of methods for evaluation of city transport hubs potential to create a universal environment is revealed. The social aspect is to improve the quality of transport services for the population, taking into account the organization of movement of citizens groups with limited mobility: the creation of comfortable conditions, the possibility of planning time, saving money, expanding the geography of trips and the choice of ways to make them. The considered requirements and recommendations for the design of a universal environment on pedestrian communications in transport hubs were the result of a comprehensive analysis of the existing experience and features of the organization of pedestrian communications in transport hubs of the metropolis.
DERMATOSES EM PACIENTES COM HIV ACOMPANHADOS EM UM HOSPITAL DE REFERÊNCIA EM JOÃO PESSOA – PARAÍBA NO ANO DE 2017
Authors: SANTIAGO ISABELLE MÁRCIA DE MEDEIROS , ALMEIDA ALBUQUERQUE RAUL JOSÉ , TRINDADE LUCIANA CAVALCANTE
Published: January 2020

A Síndrome da Imunodeficiência Adquirida (SIDA/AIDS) é causada pelo vírus da imunodeficiência humana HIV (vírus da imunodeficiência humana), que tem predileção pelo sistema imunológico, facilitando a ocorrência de infecções oportunistas cuja gravidade é variável. O principal alvo do vírus é o linfócito CD4+. No Brasil, de 2007 até junho de 2017, foram notificados no SINAN 194.217 casos de infecção pelo HIV, sendo 96.439 (15,6%) na região Nordeste e, desses, 1.116 casos na Paraíba. A pele é o órgão mais frequentemente afetado em pacientes portadores do HIV e a sua avaliação é elemento importante no processo diagnóstico e no acompanhamento dos pacientes infectados. O objetivo desse estudo foi avaliar as afecções dermatológicas que acometeram pacientes, acompanhados em um Centro de Referência estadual no atendimento dos casos de HIV/SIDA, situado em João Pessoa/Paraíba, no ano de 2017. Trata-se de um estudo epidemiológico do tipo documental retrospectivo, descritivo, longitudinal com abordagem quantitativa. Entre os 250 pacientes do hospital cujos prontuários foram revisados, 69 (27,6%) apresentaram uma ou mais doenças dermatológicas, sendo a candidíase oral a mais prevalente (31,1%) e, destes, 21 (30,4%) faziam uso de forma irregular ou não faziam uso de TARV. Foi encontrado que quanto mais baixa a imunidade ou quanto mais alta a virulência, mais comum o surgimento de doenças dermatológicas. Diante dos resultados, fica clara a importância das dermatoses no auxílio ao diagnóstico do HIV/AIDS.
MÉTODO CANGURU: CUIDADO HUMANIZADO NO PERÍODO PUERPERAL
Authors: Costa Sônia Mara Gusmão , Leite Junior Julião Jerônimo , Amaral Pereira Monique Carolina
Published: January 2020

O Método Canguru ou contato pele-a-pele foi criado na Colômbia, na década de 1970, com intuito de promover o cuidado ao recém-nascido pré-termo ou de   baixo   peso, na   ausência   de   incubadoras. É um modelo voltado para o cuidado humanizado que reúne estratégias de intervenção biopsicossocial. Este estudo consiste em um relato de experiência, construído com base em artigos científicos, e das vivências de estudantes do curso de medicina envolvidos no Projeto de Extensão: Observatório do Cuidado Humanizado do Pré-Parto e Parto, realizado no ICV. Trata-se de uma abordagem descritiva, qualitativa e exploratória, com objetivo de compreender os relatos das mulheres internadas no referido serviço, que estão sob os cuidados do setor Método Canguru. Foi possível perceber alterações psicológicas das puérperas que se encontram fragilizadas e hiperemotivas, algumas apresentando o fenômeno baby blue. O estudo permitiu evidenciar demandas de aporte psicológico e sugere a realização de oficinas terapêuticas, grupos operativos e rodas de conversa, concomitantemente com a oferta de terapias alternativas.
Implementasi Konsep Distribusi Pendapatan dalam Islam untuk Meningkatkan Kondisi Sosial Ekonomi Masyarakat di Provinsi Jawa Barat
Authors: Hamid Abdul , Prasetyowati Riris Aishah , Trisasmita Rio
Published: January 2020

This paper examines the Concept of Income Distribution in Islam through the Zakat Fund which is managed as a source of funds in improving better conditions in the socio-economic poor population in the fields of education, housing, and income to support the economic growth of West Java Province. This study uses a sample test through a quantitative method and real data to observe the correlation and potential contribution of zakat from Muslim residents who work in West Java region to the distribution of income of the poor population. For each observation variable, before-and-after regression and comparison tests are associated with the potential of zakat as a concept of the distribution of Sharia or Islamic income. Hypothesis testing of two means is used to obtain different observational results from the results of this study. There is significant diversity in the socio-economic conditions of the poor before and after the implementation of the concept of distribution of Sharia or Islamic income in West Java Province. Likewise, the hypothesis testing shows that Sharia or Islamic income distribution has a significant influence on socio-economic conditions in the fields of education, proper housing, and income of the poor population on the growth of the regional economy of West Java (GRDP). With the diversity of relationships and influences among socioeconomic variables, e.g. the income of poor people after the calculation of Zakat and improper housing with the distribution of income with the concept of Islam have opposite relationships. However, the unidirectional relationship occurs in the education on theeconomic growth of the West Java regional domestic.
ASSET MISAPPROPRIATION TENDENCY: RATIONALIZATION, FINANCIAL PRESSURE, AND THE ROLE OF OPPORTUNITY (STUDY IN INDONESIAN GOVERNMENT SECTOR)
Authors: Yusrianti Hasni , Ghozali Imam , N. Yuyetta Etna
Published: January 2020

Purpose: The purpose of this study is to analyze the relationship between Rationalization and Financial Pressure on Asset Misappropriation Tendency by mediating Opportunity in the Indonesian government sector based on the Fraud Triangle perspective.

Methodology: The Population of this study was Indonesian government employees. The Sample method was Purposive Sampling and the survey method was direct surveys, postal mail, and online surveys. The number of respondents was 363 and analyzed using Structural Equation Model with AMOS-based covariance.

Main Findings: The results show that financial pressure, rationalization, and opportunity had a significant positive effect on Asset Misappropriation Tendency. Furthermore, Opportunity mediates the relationship between rationalizations on Asset Misappropriation Tendency; However, Opportunity does not mediate the relationship between Financial Pressure and Asset Misappropriation Tendency.

Implications: This study contributes to the literature on asset misappropriation in the government sector which is rather very limited and supports the Fraud Triangle Theory. It also has several practical implications for being a source of information to formulate policies in fraud prevention and detection that will improve management control systems in the government sector a developing country.

Novelty: A limited study of asset misappropriation in the government sector in a developing country that examines the influence of element strength of Fraud Triangle in Asset Misappropriation which has been criticized by previous researchers.
KORELASI MANAJEMEN PENDIDIKAN BERBASIS MULTIKULTURAL TERHADAP BUDAYA TOLERANSI SISWA DI SMK MIFTAHUL QULUB POLAGAN GALIS PAMEKASAN TAHUN 2018
Authors: Hasan Nor , Rahman Fifi
Published: January 2020

Education management that based of multicultural tobe most important because without management, education institutions will to difficult to bring about activities of education nor is education so that the process of achievement goals education will so difficult to obtained. So that a head master must truly to conducting management and good policies and corresponded to manage education system that based of multicultural so process of education activity can more focused and to minimize the failure in education. Educations not necessarily given to student but education given based on the needs that are able to develop a knowledge, skill, and attitude of students by clearly. Education is considered capable given an understanding and an implementation from a diversity in a country is a education based of multicultural. It is based on conflict that occurs among students. Sometimes the student are difficult to mutual tolerance towards others because they feel that a habbitually or action of person is different with the habitually that they doing in every day.
ANALISIS USER INTERFACE TERHADAP WEBSITE AKTA ONLINE BANYUWANGI MENGGUNAKAN METODE HEURISTIC EVALUATION
Authors: Fitri Siti Vika Ngainul , Juwita Oktalia , Dharmawan Tio
Published: January 2020

Banyuwangi Regency has a new innovation called " Lahir Procot Pulang Bawa Akta " which in this innovation is realized in the form of an Online Deed Website. Every information technology has an interface that can be a link between the user and the technology itself. Interface formation is influenced by needs, and information technology has different interface designs according to the needs of its users. The User Interface has the aim of making it easier for users to operate information technology that can make users feel comfortable using the application or technology. Heuristic Evaluation is one of the Usability evaluation methods that can be used to determine the extent to which a system is used by users to achieve certain goals with effectiveness, efficiency and satisfaction. This research is a research that is focused on the use of Heuristic Evaluation based on user interface design aspects of application usability through observation, interviews and questionnaires to users.
Effect of Red Dragon Fruit Extract as Dye in Solar Cells
Authors: Eliyana Ajeng , Puspitarum Deska Lismawenning , Laksono Dana
Published: January 2020

Along with the development of nanotechnology, the development of solar cells entered a significant stage with the emergence of the newest generation, namely DSSC (Dye Sensitized Solar Cell). The utilization of dragon fruit skin which has been extracted as dye in dye sensitized solar cells and solar cell development to realize sustainable energy supply is the main target in this study. The method carried out begins with the synthesis of nanoparticles from organic material (TiO2), to obtain good TiO2 material as an anti-reflection, where anti-reflection is selected on DSSC technology to reduce light reflection in the visible light region. The crystal size of TiO2 was analyzed as an oxide layer material in DSSC. DSSC synthesis was carried out and the parameters of organic solar cell devices (DSSC) were optimized to obtain solar cells with good conversion efficiency. The results showed that the size of TiO2 obtained was an average of 0.211 nm and the maximum wavelength value of the extract of the dragon fruit dye solution was 530 nm. Keywords: dye, solar cell, DSSC, TiO2.
Natura 2000 fenntartási tervek részvételi folyamatainak értékelése
Authors: Kovács Eszter , Kiss Gabriella , Kelemen Eszter , Fabók Veronika , Kalóczkai Ágnes , Mihók Barbara , Pataki György , Balázs Bálint , Bela Györgyi , Megyesi Boldizsár , Margóczi Katalin
Published: January 2020

A társadalmi részvétel intézményesülésének még csak csírái találhatók meg hazánkban, ennek ellenére az érintettek bevonása a Natura 2000 területek fenntartási terveinek készítésébe már gyakorlattá vált. Értékelésük hasznos lehet a tervek készítői, a részvételi folyamatok irányítói és a természetvédelmi döntéshozók számára is. Ebben a cikkben a nemzetközi szakirodalomban alkalmazott értékelési kritériumokra építve a részvételi fenntartási tervezéshez kiválasztott és adaptált 12 szempont alapján értékelünk 23 természetvédelmi részvételi tervezési folyamatot, melyek 2007 és 2016 között valósultak meg. Vizsgálataink azt mutatják, hogy az értékelt folyamatok csak részben felelnek meg az elvárt kritériumoknak. illetve a fenntartási tervek természetvédelmi hatásainak megítéléséhez nem is rendelkezünk megfelelő információval. Az elemzésben megjelenő tervezési folyamatok erőssége a felkészült, társadalomtudományos hátterű és független részvételi csapat. Emellett azt is megállapíthatjuk, hogy a fenntartási tervezés és a kapcsolódó részvételi folyamatok sikerességéhez kiemelten fontos a támogató szakpolitikai háttér is.
A tengerek és óceánok műanyag szennyezésének komplex hatása – 2. rész: Lehetséges megoldások
Authors: Gubek István
Published: January 2020

A tengerek és óceánok műanyag szennyezése az utóbbi évek egyik egyre többet kutatott témája. Hasonlóan globális szintű környezeti probléma, mint az éghajlatváltozás vagy a biodiverzitás csökkenése, ugyanakkor a közvélemény sokkal kevesebbet tud róla, mivel ez egy új kutatási terület, illetve nincs magyar nyelvű szakirodalom a témában. Ez az első átfogó összeállítás, mely a külföldi szakirodalom részletes áttanulmányozásával készült. Az első részben részletes leírást adtam a tengeri környezetbe került műanyagok fizikai, kémiai, biológiai, ökológiai, gazdasági és társadalmi hatásairól. A mostani, második, befejező részben pedig bemutatom a már létező megoldási lehetőségeket.
Parenting Strategies for Underperforming Children
Authors: Senters Chad
Published: January 2020

Negative fracture driven interactions (FDIs) have the potential to damage offset producing wells. Overlap in drainage area during hydrocarbon production can significantly increase drilling and completion costs as well. If wells are not drilled and completed optimally, then the recovery of hydrocarbon between the wells can suffer significantly. This paper outlines methods to test and optimize drilling and completion programs through the surveillance of inter-well communication and FDIs.

Inter-well communication and FDIs are influenced by several factors, including well spacing, landing intervals, well completion, stimulation treatment design, etc. The relationship between primary and infill wells has a significant impact on inter-well communication. Completion diagnostics characterize the communication between wells.

The case histories in the paper include the results of inter-well communication and FDI findings on multiple projects. These results provide insight into future decisions, such as well spacing, staggered landing depths, frac order, treatment design, completion type, and mitigation techniques. Several mitigation techniques are available for the primary (parent) wells as well as the infill (child) wells. Mitigation techniques on primary wells include shutting it in, refracturing, and/or injecting fluid at lower rates prior to the infill completion. Mitigation techniques on infill wells include the use of near-wellbore and far-field diverting agents, and perforation cluster design.

There is still much to learn on the effects of FDIs and inter-well communication for both primary and infill wells. The case histories presented in this paper show examples of how to detect and manage the effects of FDIs and inter-well communication as well as their mitigation techniques.
Live-attenuated Salmonella enterica serotype Choleraesuis vaccine with regulated delayed fur mutation confer protection against Streptococcus suis in mice
Authors: Li Yu-an , Chen Yunyun , Du Yuan zhao , Guo Weiwei , Fan Juan , Bellefleur Matthew , Wang Shifeng , Shi Huoying
Published: January 2020

Background: Recombinant Salmonella enterica serotype Choleraesuis ( S . Choleraesuis) vaccine vector could be used to deliver heterologous antigens to prevent and control pig diseases. We have previously shown that a live-attenuated S . Choleraesuis vaccine candidate strain rSC0011 (ΔP crp527 ::TT araC P BAD crp Δ pmi-2426 Δ relA199 :: araC P BAD lacI TT Δ asdA33 , Δ, deletion, TT, terminator) delivering SaoA, a conserved surface protein in most of S . suis serotypes, provided excellent protection against S. suis challenge, but occasionally lead to morbidity (enteritidis) in vaccinated mice (approximately 1 in every 10 mice). Thus, alternated attenuation method was sought to reduce the reactogenicity of strain rSC0011. Herein , we described another recombinant attenuated S. Choleraesuis vector, rSC0012 ( ΔP fur88 :: TT araC P BAD fur Δ pmi-2426 Δ relA199 :: araC P BAD lacI TT Δ asdA33 ) with regulated delayed fur mutation to avoid inducing disease symptoms while exhibiting a high degree of immunogenicity. Results: The strain rSC0012 strain with the ΔP fur88 ::TT araC P BAD fur mutation induced less production of inflammatory cytokines than strain rSC0011 with the ΔP crp527 ::TT araC P BAD crp mutation in mice. When delivering the same pS-SaoA plasmid, the intraperitoneal LD 50 of rSC0012 was 18.2 times higher than that of rSC0011 in 3-week-old BALB/C mice. rSC0012 with either pS-SaoA or pYA3493 was cleared from spleen and liver tissues 7 days earlier than rSC0011 with same vectors after oral inoculation. The strain rSC0012 synthesizing SaoA induced high titers of anti-SaoA antibodies in both systemic (IgG in serum) and mucosal (IgA in vaginal washes) sites, as well as increased level of IL-4, the facilitator of Th2-type T cell immune response in mice. The recombinant vaccine rSC0012(pS-SaoA) conferred high percentage of protection against S. suis or S . Choleraesuis challenge in BALB/C mice. Conclusions: The live-attenuated Salmonella enterica serotype Choleraesuis vaccine rSC0012(pS-SaoA) with regulated delayed fur mutation provides a foundation for the development of a safe and effective vaccine against S . Choleraesuis and S. suis .
The Efficacy of Antipyretic Analgesics Administration Intravenously for Preventing Rocuronium-Associated Pain/Withdrawal Response: A Systematic Review and Meta-Analysis
Authors: Wang Jia , Liu Bin , Cui Yu , Chen Jianfeng
Published: January 2020

Background: Rocuronium-associated injection pain/withdrawal response (RAIPWR) was non-ideal but occurred frequently when injection intravenously during anesthesia induction. Many studies had reported that pretreating with antipyretic analgesics (AAs) could reduce the occurrence of RAIPWR, but there was no consensus yet. Therefore, this meta-analysis was designed to systematically evaluate the benefits of AAs on RAIPWR in patients.
Methods: PubMed, Cochrane Library, Ovid, EMbase, Chinese National Knowledge Infrastructure (CNKI), Wan Fang Data were searched by January 1st 2019 for randomized controlled trials (RCTs) applying AAs to alleviate RAIPWR in patients underwent elective surgery under general anesthesia. Two investigators assessed quality of RCTs and extracted data respectively and the meta-analysis was carried on Revman 5.3 software. Moreover, we compared AAs in pros and cons directly with lidocaine, the most reported medicine to prevent RAIPWR.
Results: Data were analyzed from 9 RCTs totaling 819 patients. The results of Meta-analysis showed that compared to the control group, pretreating with AAs could prevent the total occurrence of RAIPWR [Risk ratio (RR), 0.52; 95% confidence interval (CI), 0.42 to 0.66; P < 0.0001], and took effect on moderate (RR, 0.56; 95%CI, 0.43 to 0.73; P<0.0001) and severe RAIPWR (RR=0.14; 95%CI, 0.08 to 0.24; P<0.00001). When compared to lidocaine, the preventive effect was not so excellent as the latter but injection pain induced by prophylactic occurred less.
Conclusion: The currently available evidence suggested that pretreating with AAs intravenously could alleviate RAIPWR.
SERT and BDNF polymorphisms interplay on neuroticism in borderline personality disorder
Authors: Salinas Valeria , Villarroel Juana , Silva Hernán , Herrera Luisa , Jerez Sonia , Zazueta Alejandra , Montes Cristian , Nieto Rodrigo , Bustamante M. Leonor
Published: January 2020

Objective Genetic factors underlying different personality traits are not entirely understood, particularly how genes interact to modulate their effect. We studied 76 patients diagnosed with borderline personality disorder (BPD), characterized by extreme levels of personality traits, especially neuroticism (N), in which we genotyped two polymorphisms, the 5HTTLPR of the Serotonin transporter (SERT) gene, and the Val66Met of the Brain-derived neurotrophic factor (BDNF) gene. Results We found an association with SERT, where S-allele carriers had significantly higher levels of N than L-homozygous. Furthermore, we found that the protective effect of L-homozygosity is only evident on A-allele carriers of the BDNF Val66Met polymorphism. Genetic constitution in SERT and BDNF seems to be important in neuroticism, the most relevant personality trait on BPD.
Efficacy and safety of artesunate-amodiaquine and artemether-lumefantrine and prevalence of molecular markers associated with resistance, Guinea, 2016
Authors: Beavogui Abdoul Habib , Camara Alioune , Delamou Alexandre , Doumbouya Abdoulaye , Kourouma Karifa , Bouedouno Patrice , Guilavogui Timothee , Santos Souza Samaly dos , Kelley Julia , Talundzic Eldin , Fofana Aissata , Plucinski Mateusz M
Published: January 2020

Background: Antimalarial resistance is a threat to recent gains in malaria control. This study aimed to assess the efficacy and safety of artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) in the management of uncomplicated malaria and to measure the prevalence of molecular markers of resistance of Plasmodium falciparum in sentinel sites in Maferinyah and Labé Health Districts in Guinea in 2016.Methods: This was a two-arm randomized controlled trial of the efficacy of AL and ASAQ in children aged 6-59 months with P. falciparum monoinfection in two sites. Children were followed for 28 days to assess clinical and parasitological response. The primary outcome was the Kaplan-Meier estimate of Day 28 (D28) efficacy after correction by microsatellite-genotyping. Pre-treatment (D0) and day of failure samples were assayed for molecular markers of resistance in the pfk13 and pfmdr1 genes.Results: A total of 421 participants were included with 211 participants in the Maferinyah site and 210 in Labé. No early treatment failure was observed in any study arms. However, 22 (5.3%) participants developed a late treatment failure, which were further classified as 2 recrudescences and 20 reinfections. The Kaplan-Meier estimate of the corrected efficacy at D28 was 100% for both AL and ASAQ in Maferinyah site and 99% (95% Confidence Interval: 97.2-100%) for ASAQ and 99% (97.1-100%) for AL in Labé. The majority of successfully analyzed D0 (98%, 380/389) and all day of failure (100%, 22/22) samples were wild type for pfk13. All 9 observed pfk13 mutations were polymorphisms not associated with artemisinin resistance. The NFD haplotype was the predominant haplotype in both D0 (197/362, 54%) and day of failure samples (11/18, 61%) successfully analyzed for pfmdr1.Conclusions: This study observed high efficacy and safety of both ASAQ and AL in Guinea, providing evidence for their continued use to treat uncomplicated malaria. Continued monitoring of ACT efficacy and safety and molecular makers of resistance in Guinea is important to detect emergence of parasite resistance and to inform evidence-based malaria treatment policies.
The effects of Bunium Persicum (Black Caraway) supplementation on glycemic indices, lipid profiles and serum levels of nesfatin-1 in overweight and obese patients with type 2 diabetes: a double-blind randomized placebo-controlled clinical trial
Authors: Jafari-Maskouni Saber , Shahraki Mansour , Daneshi-Maskooni Milad , Dashipour Alireza , Shamsi-Goushki Ali , Mortazavi Zinat
Published: January 2020

Background: Diabetes mellitus is the most common metabolic disorder worldwide. Our aim was to determine the effects of bunium persicum (BP) on serum glucose indices, lipid profile, and nesfatin-1 levels among overweight or obese T2DM patients.Methods: The place of participant recruitment was the diabetic clinic of Bu-Ali hospital in Zahedan. Based on the eligibility criteria, 60 participants were randomly divided into two groups as BP (n=30) or placebo (n=30). The supplementation was one 1000 mg capsules 2 times/day BP with launch and dinner for 8 weeks. Bodyweight, Waist circumference, serum nesfatin-1, fasting blood sugar (FBS), insulin (FBI), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured. Quantitative insulin sensitivity checks index (QUICKI), homeostasis model assessment-insulin resistance (HOMA-IR) and Body Mass Index (BMI) were also calculated.Results: In comparison with placebo, PB significantly increased QUICKI and decreased FBS, HOMA-IR, BMI and WC (P<0.05). At the end of the study after adjustment for confounders, the changes were similar (P<0.05) with an exception for QUICKI which had a trend (P=0.054) and WC (P > 0.05). The differences in the FBI, TG, TC, LDL, HDL and Nesfatin-1 were not significant (P>0.05).Conclusion: PB supplement improved serum glucose indices and decreased BMI among overweight or obese T2DM patients; though, further trials are suggested to confirm results.
Comprehensive arginine metabolomics and peripheral vasodilatory capacity in rheumatoid arthritis: a monocentric cross-sectional study.
Authors: Erre Gian Luca , Mangoni Arduino Aleksander , Passiu Giuseppe , Bassu Stefania , Castagna Floriana , Carru Ciriaco , Piga Matteo , Zinellu Angelo , Sotgia Salvatore
Published: January 2020

Background The relationship between plasma arginine metabolites influencing vascular homeostasis and peripheral vasodilatory capacity in rheumatoid arthritis (RA) patients is not known. Methods L-arginine (Arg), monomethyl-L-arginine (MMA), L-homoarginine (hArg), asymmetric dimethyl-L-arginine (ADMA), symmetric dimethyl-L-arginine, and L-citrulline (Cit) were measured by LC-MS/MS in 164 RA patients and 100 age- and sex-matched healthy controls without previous cardiovascular events. Log-transformed reactive hyperemia index (Ln-RHI) evaluated by peripheral arterial tonometry (PAT, EndoPAT2000 device) was assessed as surrogate measure of peripheral vasodilatory capacity in RA patients. Ln-RHI values <0.51 indicated peripheral endothelial dysfunction (ED). The relationship between plasma arginine metabolite concentrations, RA descriptors and peripheral vasodilatory capacity was evaluated by bivariate correlation and regression analyses. Results Plasma ADMA concentrations were significantly higher, and plasma hArg concentrations significantly lower, in RA patients than in controls (0.53 ± 0.09 vs 0.465 ± 0.07 μmol/L and 1.50 ± 0.60 vs 1.924 ± 0.78 μmol/L, respectively; p<0.001 for both comparisons). Bivariate correlation analysis demonstrated no significant correlation between arginine metabolites and disease descriptors. In regression analysis in RA patients, higher plasma ADMA concentrations were independently associated with presence of ED [OR(95%CI) = 77.3(1.478 - 4050.005), p =0.031] and lower Ln-RHI [B coefficient(95%CI) =-0.57(-1.09 to -0.05), p =0.032]. Conclusions ADMA was significantly, albeit weakly, associated with impaired microcirculatory vasodilatory capacity and peripheral endothelial dysfunction in RA. This suggests an important pathophysiological role of this metabolite in the vascular alterations observed in this patient group.
Gelatin hydrogels with eicosapentaenoic acid can prevent osteoarthritis progression in vivo in a mouse model
Authors: Tsubosaka Masanori , Kihara Shinsuke , Hayashi Shinya , Nagata Junpei , Kuwahara Toshie , Fujita Masahiro , Kikuchi Kenichi , Takashima Yoshinori , Kamenaga Tomoyuki , Kuroda Yuichi , Takeuchi Kazuhiro , Takayama Koji , Hashimoto Shingo , Matsumoto Tomoyuki , Niikura Takahiro , Tabata Yasuhiko , Kuroda Ryosuke
Published: January 2020

Background Eicosapentanoic acid (EPA) is an antioxidant and omega-3 polyunsaturated fatty acid that reduces inflammatory cytokine production. Gelatin hydrogel is a release technology that contains a physiologically active substance and releases the substance gradually for an average of ~3 weeks. Therefore, this study aimed to investigate the effect of EPA-incorporating gelatin hydrogels on osteoarthritis (OA) progression in vivo . Methods Ten-week-old male C57BL/6J mice were randomly divided into six groups (six mice each): sham, destabilization of the medial meniscus (DMM), Corn (DMM + 2 µl corn oil), EPA-I (DMM + 2 µl corn oil + 3 mg/ml EPA), Control (DMM + control gelatin hydrogels), and EPA-G (DMM + 3 mg/ml EPA-incorporating gelatin hydrogels) groups. Mice were then euthanized 8 weeks after DMM or sham surgery, and subjected to histological evaluation. Furthermore, MMP-3, MMP-13, IL-1β, p-IKK α/β, CD86, and CD163 was detected by immunohistochemical staining. F4/80 expression was also assessed using the F4/80 score of synovitis. Results Histologic score was significantly improved in EPA-G compared to in EPA-I. MMP-3-, MMP-13-, IL-1β-, and p-IKK α/β-positive cell ratio was significantly improved in EPA-G compared to in EPA-I. However, CD86- and CD163-positive cell ratio was not significantly different between EPA-I and EPA-G. The average-sum F4/80 score of synovitis in EPA-G was significantly improved compared to in EPA-I. Conclusions EPA-incorporating gelatin hydrogels can prevent OA progression in vivo more effectively than single injection of EPA. Our results suggested that intra-articular administration of controlled-release EPA can be a new therapeutic approach for treating OA.
Young Medical Doctors’ Perspectives on Professionalism: A Qualitative Study Conducted in Public Hospitals in Pakistan
Authors: Jalil Aisha , Mehmood Qaisar Khalid , Fischer Florian
Published: January 2020

Background: Professionalism is amongst the major dimensions indicating the competence of medical doctors. A decline in professionalism affects the overall outcome of healthcare services. This study explores the patterns of declining professionalism among young medical doctors in Pakistan.Methods: A qualitative study based on in-depth interviews was conducted with 60 young medical doctors aged less than 40 years who were employed at various levels from house officer to consultant specialist in public tertiary hospitals in Pakistan. The respondents were identified through a multistage maximum heterogeneity sampling strategy. A semi-structured interview guide was developed based on a previous extensive literature review. Written consent was obtained from the hospitals and study participants. Thematic content analysis was applied to analyse the data. Results: The data analysis revealed a rigidity of opinions, inflexibility blocking the acceptance of contrasting perspectives, and perceived superiority over all other professions and over patients. The belief that patients know nothing was common among all participants. Similarly, doctors believed that there is no need to include a professionalism and humanity course in the medical school curriculum. The majority of respondents thought that social science topics are irrelevant to medicine and are common-sense things that they already know. The doctors recognised high professionalism in themselves, while reporting unprofessional behaviour demonstrated by their colleagues. The reported characteristics include using social media applications during duty hours, ridiculing patients, substance use such as cigarettes in the office, referrals of complicated cases to other hospitals, freeing up beds before holidays and inappropriate salaries. Conclusions: It seems that professionalism has declined among young doctors, and this should be immediately addressed by policymakers. The lack of training about ethics and healthcare service delivery, and a lack of performance monitoring and evaluation mechanisms at public hospitals are the major factors contributing to declining professionalism. There is a need to revisit the curriculum taught to medical students in order to strengthen professionalism.
Prevalence and Correlates of Bullying in Physiotherapy Education in Nigeria
Authors: Mbada Chidozie Emmanuel , Ogunseun Idowu Phebean , Fasuyi Francis Oluwafunso , Adegbemigun Oluwafemi David , Fatoye Clara Toyin , Idowu Opeyemi Ayodiipo , Johnson Olubusola Esther , Odole Adesola Christiana , Okonji Adaobi Margaret , Kaka Basir , Fatoye Francis
Published: January 2020

Background: Bullying is an unexpressed part and parcel of medical education but it is largely unexplored in physiotherapy. This study assessed the prevalence and socio-demographic correlates of bullying in physiotherapy education in Nigeria.Methods: Two hundred and nineteen clinical physiotherapy students from three purposively selected Federal Universities in Nigeria participated in this study. Following a cross-sectional design, the Students Perception of Professor Bullying Questionnaire (SPPBQ) was used to obtain information on bullying. The SPPBQ includes a working definition of lecturer bullying followed by two sections inquiring about lecturers bullying experiences. Data was collected on socio-demographic characteristics, availability of adequate policy and support and the different forms of bullying experienced. Descriptive and inferential statistics were used analyze data. Alpha level was set at p<0.05. Results: Lifetime and point prevalence of bullying in physiotherapy education was 98.6% and 99.1% respectively. 94.5% of the respondents had witnessed physiotherapy students bullying and there was a 100% rate of ‘no attempt’ to stop a physiotherapy lecturer from bullying. There was no significant association between bullying and each of age (𝜒2=0.117, p=0.943), gender (𝜒2=0.001,p=0.974), university (𝜒2=1.343,p=0.511) and level of study (𝜒2=0.000,p=0.995). Conclusion: There is high lifetime and point prevalence of bullying in physiotherapy education in Nigeria, which are largely unchallenged or redressed. Also, being a clinical physiotherapy student makes prone to bullying without necessary contributions of other intrinsic and extrinsic factors.
Transarterial Chemoembolization Combined with Iodine 125 Seeds Versus Transarterial Chemoembolization Combined with Radiofrequency Ablation in the Treatment of Early and Intermediate Hepatocellular Carcinoma
Authors: lei chen , Kan Xuefeng , Sun Tao , Ren Yanqiao , Cao Yanyan , Yan Liangliang , Liang Bin , Xiong Bin , Zheng Chuansheng
Published: January 2020

Background To compare the efficacy of the combination of transarterial chemoembolization (TACE) and iodine 125 seeds implantation (TACE-Iodine 125) with the combination of TACE and radiofrequency ablation (RFA) in the treatment of patients with early and intermediate hepatocellular carcinoma (HCC). Methods The study included 134 patients diagnosed with early and intermediate HCC from January 1, 2014, to May 31, 2018. Among them, 47 patients were treated with TACE-Iodine 125, and 87 with TACE-RFA and the efficacy of both treatments was analyzed. To reduced selective bias, propensity score matching (PSM) was used to compare the outcomes of the treatments. Results In the absence of PSM, the median overall survival (OS) and progression-free survival (PFS) of the TACE-RFA group were slightly longer than those of the TACE-Iodine 125 group (OS: 42 months vs. 37 months; PFS: 18 months vs. 15 months). However, there was no significant difference in median OS, PFS, and the objective response rate (ORR) between the two groups (P>0.05). After adjusted for age, gender, liver resection, Child-Pugh class, Barcelona Clinic Liver Cancer (BCLC) stage and Alpha-fetoprotein (AFP), TACE-Iodine 125 treatment was not associated with a significant increasing in risk of death (HR: 0.725; 95%CI: 0.423,1.241, P=0.241) and recurrence (HR: 1.008; 95%CI: 0.666,1.526, P=0.969). After PSM, 47 patient pairs were generated, and there was no significant difference in median OS and PFS between the two groups. Conclusions The combination of TACE and iodine 125 seeds implantation may represent an effective treatment for patients with early and intermediate HCC.
A systematic review of the association between fibromyalgia and functional gastrointestinal disorders
Authors: Erdrich Sharon
Published: January 2020

Background Fibromyalgia and functional gastrointestinal disorders are frequently encountered in clinical settings. Common to both is significant burden on individuals and health care systems, an elusive aetiology and several comorbid conditions. While a relationship between irritable bowel syndrome and fibromyalgia has been demonstrated, a broader review of the relationship between fibromyalgia and other functional gut disorders has not been undertaken. Objectives This paper reports a systematic review of the published literature, identifying the comorbidity of functional gastrointestinal disorders in people with fibromyalgia. We discuss the clinical implications, limitations of current research, and areas of interest for future research Methods A systematic review of the databases Medline, Embase, CINAHL and Web of Science was undertaken in June 2019. Results were screened for original articles meeting strict criteria for identification of functional gastrointestinal disorders in adult subjects with fibromyalgia. ResultsFourteen articles were included investigating 1340 subjects with fibromyalgia, 363 healthy controls and 441 subjects with other pathologies. Functional gut disorders were matched to Rome II criteria for reporting and comparison. In addition to increased abdominal pain and functional bloating/gas, irritable bowel of mixed-pattern and constipation-types were more prevalent that diarrhoea-predominant irritable bowel in adults with fibromyalgia. One study reported the range of functional gastrointestinal disorders. Conclusion Existing research has focused on the relationship between irritable bowel syndrome and fibromyalgia, but sub-typing of irritable bowel syndrome is generally overlooked. A strong association with a range of functional gastrointestinal disorders is suggested. Further investigation is needed to determine the prevalence and relevance of the range of functional gastrointestinal disorders in patients with fibromyalgia.
Analysis Of The Relationship Between Facial Type And Gingival Phenotype 
Authors: Cambiaghi Lucas , Job Pedro Henrique Henriques , Freitas Nicole Rosa de , Garcia Vitor Eduardo Albino , Almeida Ana Lúcia Pompéia Fraga De
Published: January 2020

Background The width of attached gingiva depends on the height of the alveolar process and lower vertical dimension of the face .The relationship between facial type and gingival phenotype may be extremely important in the orthodontic planning. This study analyzed the relationship between facial types and different types of tooth crowns with the characteristics of the gingival tissue. Methods 90 maxillary central incisors of 45 individuals were evaluated, aged 15 to 35 years, of both genders. The analysis addressed the width and thickness of keratinized gingiva (gingival phenotype) and dimensions of tooth crowns. The individuals were scored according to the facial type. The relationship between width of keratinized gingiva and gingival phenotype was correlated to the facial type (brachyfacial, mesofacial or dolichofacial) and size and shape of maxillary central incisors. The results were statistically analyzed by the Spearman correlation test (to evaluate the relationship between shape of tooth crowns and gingival biotype) and Kruskal-Wallis (to analyze the influence of facial types on the gingival characteristics), both at a significance level of 5%.Results There was correlation between the gingival width and crown shapes (p=0.00). There were no statistically significant differences between facial types and width of keratinized gingiva (p=0.33) and between facial types and thickness of keratinized gingiva (p=0.09).Conclusions Within the limitations, we conclude that the facial types did not seem to influence the gingival phenotype; however, the crown shapes seemed to be related to the quantity of keratinized gingiva.
Rapid referral for headache management from Emergency Department to Headache Centre: four years data
Authors: Negro Andrea , Spuntarelli Valerio , Sciattella Paolo , Martelletti Paolo
Published: January 2020

Background Headache is one of the most common reason for medical consultation to emergency department (ED). Inappropriate use of ED for non-urgent conditions is a problem in terms of crowding emergency facilities, unnecessary testing and treatment, increased medical bills, burden on medical service providers and weaker patient-primary care provider relationships. The aim of this study was to analyzed the different steps of the ED management of patients with headache to detect those deficiencies that can be overcome by a prompt referral to a headache clinic.Methods The study is a retrospective analysis of the electronic medical records (EMRs) of patients discharged from an academic ED between 1 January 2015 and 31 December 2018 and referred to the tertiary level headache centre of the same hospital. We analyzed all the aspects related to the permanence in ED and we also assessed if there was a concordance between ED diagnosis and ours.Results Among our sample of 244 patients, 76.2% were admitted as green tag, 75% underwent a head computed tomography, 19.3% received neurological consultation, 43% did not receive any pharmacological treatment and 62.7% still had headache at discharge. Length in ED stay was associated with the complaint of the first aura ever (p = 0.014) and if patients received consultations (p < 0.001). Concordance analysis shown a significant moderate agreement only for the diagnosis of migraine and only between triage and headache centre.Conclusions The majority of patients who went to the ED complaining of headache received the same therapy regardless of their diagnosis and in many cases the headache had not yet resolved at the time of discharge. Given the several shortcomings of ED management of headaches, a rapid referral to the headache centre is of primary importance to help the patient obtain a definite diagnosis and adequate treatment.