bluuebunny/crossref_metadata_2025 huggingface dataset:
Multigenerational Consequences of Prenatal Exposure to Benzophenone-3 Demonstrate Sex- and Region-Dependent Neurotoxic and Pro-Apoptotic Effects in Mouse Brain
Authors: Przepiórska-Drońska Karolina , Łach Andrzej , Pietrzak-Wawrzyńska Bernadeta Angelika , Rzemieniec Joanna , Kajta Małgorzata , Wawrzczak-Bargieła Agnieszka , Bilecki Wiktor , Noworyta Karolina , Wnuk Agnieszka
Published: December 2024

Benzophenone-3 (BP-3), commonly used as a UV filter in personal care products and as a stabilizer, is an alleged endocrine disruptor with potential neurodevelopmental impacts. Despite its abundance in the environment, the studies on its effect on brain development are scarce, especially in terms of multigenerational impact. In this work, for the first time, we examined neurotoxic and pro-apoptotic effects of BP-3 on mouse brain regions (cerebral cortex and hippocampus) in both the first (F1) and second (F2) generations after maternal exposure to environmentally relevant BP-3 levels. We found disregulated markers of cell damage (LDH, H2O2, caspase-3 and -8) and observed increased expression of pro-apoptotic Fas/FAS or Fasl/FASL. BP-3 exposure disrupted the BAX/BCL2 pathway, showing stronger effects in the F1 than in the F2 generation, with a dominance of extrinsic pathway (FAS, FASL, caspase-8) over intrinsic one (BAX, BCL2), suggesting that BP-3-induced apoptosis primarily operates via the extrinsic pathway and could impair brain homeostasis across generations. This study underscores the potential of BP-3 to increase multigenerational risks associated with disrupted neurodevelopment and highlights the importance of understanding its long-term neurotoxic effects.
The Protein Engineering of Zearalenone Hydrolase Results in a Shift in the pH Optimum of the Relative Activity of the Enzyme
Authors: Dotsenko Anna , Sinelnikov Igor , Zorov Ivan , Denisenko Yury , Rozhkova Aleksandra , Shcherbakova Larisa
Published: December 2024

An acidic shift in the pH profile of Clonostachys rosea zearalenone hydrolase (ZHD), the most effective and well-studied zearalenone-specific lactone hydrolase, is required to extend the range of applications for the enzyme as a decontamination agent in the feed and food production industries. Amino acid substitutions were engineered in the active center of the enzyme to decrease the pKa values of the catalytic residues E126 and H242. The T216K substitution provided a shift in the pH optimum by one unit to the acidic region, accompanied by a notable expansion in the pH profile under acidic conditions. The engineered enzyme demonstrated enhanced activity within the pH range of 3–5 and improved the activity within the pH ranging from 6 to 10. The D31N and D31A substitutions also resulted in a two-unit shift in the pH optimum towards acidic conditions, although this was accompanied by a significant reduction in the enzyme activity. The D31S substitution resulted in a shift in the pH profile towards the alkaline region. The alterations in the enzyme properties observed following the T216K substitution were consistent with the conditions required for the ZHD application as decontamination enzymes at acidic pH values (from 3.0 to 6.0).
When It Rains, It Pours: Compounding Housing Issues and Precarity Among Disabled Adults in the United States, 2019–2022
Authors: Sellers Chloe M. , Pasciuti Daniel S. , Tilder Madelief L. , Leeder Lauren B. , Anderson Raeda K.
Published: December 2024

The multi-decade housing crisis has emerged as a critical aspect of both the ability of individuals to remain housed within the community as well as a critical health concern that impacts the long-term well-being through the presence or absence of both physical space and facilities in the home. We employ national state-level data from the American Community Survey (ACS) and aggregated measures from the Annual Disability Statistics Compendium to analyze six housing metrics—complete kitchen and plumbing access, overcrowding, housing cost burden, old housing, and poor housing. Using a lagged time-series regression analysis, we found the prevalence of cost burdened households in 2022 when accounting for individual and compounding housing metrics, and housing types, from 2019 to 2022, across community-living adults by disability status. Ultimately, we demonstrate that the carryover effects of housing issues is a greater contributor to housing cost burden than concurrent housing issues. This compounding and multi-faceted crisis further demonstrates that housing conditions and affordability need to be considered primary factors in the study and support of people with disabilities. Additionally, there is an urgent need for inclusive housing policies that address the challenges faced by disabled individuals to promote equitable access to sustainable, quality housing as a fundamental component of public health.
Assessment of the Effect of Deleting the African Swine Fever Virus Gene R298L on Virus Replication and Virulence of the Georgia2010 Isolate
Authors: Ramirez-Medina Elizabeth , Velazquez-Salinas Lauro , Valladares Alyssa , Silva Ediane , Burton Leeanna , Gladue Douglas P. , Borca Manuel V.
Published: December 2024

African swine fever (ASF) is a lethal disease of domestic pigs that is currently challenging swine production in large areas of Eurasia. The causative agent, ASF virus (ASFV), is a large, double-stranded and structurally complex virus. The ASFV genome encodes for more than 160 proteins; however, the functions of most of these proteins are still in the process of being characterized. The ASF gene R298L, which has previously been characterized as able to encode a functional serine protein kinase, is expressed late in the virus infection cycle and may be part of the virus particle. There is no description of the importance of the R298L gene in basic virus functions such as replication or virulence in the natural host. Based on its evolution, it is proposed that there are four different phenotypes of R298L of ASFV in nature, which may have potential implications for R298L functionality. We report here that a recombinant virus lacking the R298L gene in the Georgia 2010 isolate, ASFV-G-∆R298L, does not exhibit significant changes in its replication in primary cultures of swine macrophages. In addition, when experimentally inoculated in pigs, ASFV-G-∆R298L induced a fatal form of the disease similar to that caused by the parental virulent ASFV-G. Therefore, deletion of R298L does not significantly affect virus replication and virulence in domestic pigs of the ASFV Georgia 2010 isolate.
Azelastine Nasal Spray in Non-Hospitalized Subjects with Mild COVID-19 Infection: A Randomized Placebo-Controlled, Parallel-Group, Multicentric, Phase II Clinical Trial
Authors: Meiser Peter , Flegel Michael , Holzer Frank , Groß Dorothea , Steinmetz Charlotte , Scherer Barbara , Jain Rajesh ,   CARVIN-II Study Group
Published: December 2024

Nasal spray treatments that inhibit the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) entry into nose and nasopharynx at early stages can be an appropriate approach to stop or delay the progression of the disease. We performed a prospective, randomized, double-blind, placebo-controlled, parallel-group, multicentric, phase II clinical trial comparing the rate of hospitalization due to COVID-19 infection between azelastine 0.1% nasal spray and placebo nasal spray treatment groups. The study furthermore assessed the reduction in virus load in SARS-CoV-2-infected subjects estimated via quantitative reverse transcriptase polymerase chain reaction (RT-PCR) using nasopharyngeal swabs in both groups during the treatment period. A total of 294 subjects with mild COVID-19 infection were screened and randomized in a 1:1 ratio. There was no incidence of COVID-19-related hospitalization in either treatment group. Mean virus load was significantly reduced in both groups during the 11 treatment days as compared with baseline viral load values. The reduction in virus load in the azelastine 0.1% nasal spray group was significantly higher than the reduction in the placebo group at day 11 (log10 5.93 vs. log10 5.85 copies/mL, respectively, p = 0.0041). A total of 39 (32.0%) subjects in the azelastine 0.1% treatment group and 40 (31.0%) subjects in the placebo group reported 48 and 51 adverse events, respectively. It is therefore concluded that azelastine 0.1% nasal spray is an efficacious, safe, and well-tolerated treatment of mild COVID-19 infection.
Impact of Repeated Variant Exposures on Cellular and Humoral Immunogenicity Induced by SARS-CoV-2 Vaccines
Authors: Fernández-Ciriza Leire , del Pozo José Luis , Betanzos Nazaret , González Álvaro , Fernandez-Montero Alejandro , Carmona-Torre Francisco , Vidaurreta Marta , Carlos Silvia , Reina Gabriel
Published: December 2024

Background/Objectives: The emergence of the Omicron variant has complicated COVID-19 control and prompted vaccine updates. Recent studies have shown that a fourth dose significantly protects against infection and severe disease, though long-term immunity data remain limited. This study aimed to assess Anti-S-RBD antibodies and interferon-γ levels in healthcare workers 12 months after receiving bivalent Original/Omicron BA.4-5 fourth SARS-CoV-2 vaccine. Methods: In this prospective cohort study, 549 healthcare workers were categorized by the initial vaccination schedule, with 229 individuals having received the fourth SARS-CoV-2 vaccine dose. Blood samples were collected from all participants 12 months post-vaccination. Results: Significant differences in Anti-S-RBD antibody levels were observed between those receiving a fourth dose and those who did not, while no differences were seen in interferon-γ levels. After 12 months, there were no significant differences in humoral and cellular immunity response between volunteers primoinfected or reinfected across different periods by the Omicron variant. A multivariable analysis revealed an association between high antibody levels (>6000 U/mL) and interferon-γ levels (OR: 3.13; 95% CI: 1.3–7.7; p < 0.05). Regarding primary vaccine schedules, participants vaccinated with ChAdOx1 (a single or double dose) had notably lower antibody levels compared to those who received mRNA-based vaccines. Additionally, the study shows a higher frequency of multiple infections among those with a single-dose ChAdOx1 primary schedule (OR: 6.24; 95% CI: 1.25–31.15; p < 0.01). Conclusions: Overall, mRNA-based vaccines exhibited stronger long-term immunogenicity. Repeated exposure to the Omicron variant seems to mitigate immune imprinting from the wild-type SARS-CoV-2. An association was observed between high antibody levels and a strong cellular response, although the correlation was not linear.
Reported Adverse Events Following SARS-CoV-2 Vaccinations in the Canadian Province of Alberta and Associated Risk Factors: A Retrospective Cohort Study
Authors: Mansou Yei , Kumaran Mahalakshmi , Farmer Gregory , Kemp Kyle , Usman Hussain , Strong David , Mutwiri George K. , Sikdar Khokan C.
Published: December 2024

Background/objectives: Coronavirus-19 (COVID-19) vaccines represent a significant milestone in the fight against coronavirus disease. Ongoing post-marketing surveillance and research are crucial for ensuring vaccine safety and effectiveness, aiding public health planning. Methods: Our retrospective cohort study included Albertans five years and older and vaccinated with at least one dose of an approved COVID-19 vaccine between 14 December 2020 and 30 April 2022. This epidemiological study aimed to determine the incidence of reported adverse events following immunization (AEFI) in Alberta and identify associated risk factors. Results: The study included 3,527,106 vaccinated Albertans who met the study inclusion criteria. A total of 2541 individuals (72.0 per 100,000) reported an AEFI, with 2759 adverse events, most of which occurred following the first dose of vaccine and within the first week post-vaccination. Of these, 70.4% were female, and the highest incidence was in the 35–54 age group. Given that mRNA vaccines were predominantly administered across Canada, we report AEFI rates (per 100,000 doses) for the mRNA vaccine brands at 27.7 for Pfizer and 40.7 for Moderna. Allergic events were the most frequently reported AEFI, followed by adenopathy. Logistic regression analysis indicated that sex (with females at higher risk), presence of comorbidities, days to symptom onset, vaccine type (mRNA vs. mixed doses), and the number of doses were significant factors associated with an AEFI event. Conclusions: Our study provides valuable information to guide policies surrounding COVID-19 vaccination. While the risk of serious adverse events was low in the population-based sample, further research is warranted to identify and investigate other possible risk factors that are still unknown.
Multi-Component Protein Vaccine Induces a Strong and Long-Term Immune Response Against Monkeypox Virus
Authors: Yang Xiaolan , Sun Yakun , Gu Hongjing , Li Deyu , Zhang Liangyan , Li Tao , Wang Hui
Published: December 2024

Background/Objectives: Since 2022, outbreaks of monkeypox have raised widespread concern and have been declared a public health emergency of international concern by the World Health Organization. There is an urgent need to develop a safe and effective vaccine against the monkeypox virus (MPXV). Recombinant protein vaccines play a significant role in the prevention of infectious diseases due to their high safety and efficacy. Methods: We used the A29, E8, M1, A35, and B6 proteins of MPXV as candidate antigens to generate a panel of multi-component MPXV vaccine candidates, which were administered subcutaneously to immunize mice. Results: The results showed that the vaccine candidates Mix-AEM, Mix-AEMA, Mix-AEMB, and Mix-AEMAB effectively elicited strong neutralizing antibody responses and demonstrated significant protection against vaccinia virus (VACV) infection in a murine model. The vaccine candidate Mix-AEM induced significantly higher levels of neutralizing antibodies, cellular immunity capacity, and virus clearance compared to the vaccine candidate Mix-AE (lacking M1). Single-component immunization showed that M1 induced higher levels of neutralizing antibodies than A29 and E8. These results indicated that M1 is a critical and essential antigen in the MPXV vaccine. The number of cells secreting IFN-γ was significantly increased in the Mix-AEMA and Mix-AEMAB groups compared to the A35-deficient vaccine candidates, demonstrating the important role of A35 in inducing IFN-γ secreting. In addition, the neutralizing antibodies induced by these multi-component vaccine candidates were maintained at high levels six months after the third immunization. Conclusions: In summary, this study lays the groundwork for combining antigens to develop multi-component subunit vaccines.
Vaccine Hesitancy and Associated Factors Amongst Health Professionals: A Scoping Review of the Published Literature
Authors: Christodoulakis Antonios , Bouloukaki Izolde , Aravantinou-Karlatou Antonia , Zografakis-Sfakianakis Michail , Tsiligianni Ioanna
Published: December 2024

Background/Objectives: Healthcare professionals (HCPs) hold significant influence over public attitudes toward vaccinations. Studies suggest that HCPs are hesitant towards the coronavirus disease 2019 (COVID-19) vaccines. This hesitancy could lead to lower vaccination rates in the community. Therefore, this scoping review aimed to assess the extent of hesitancy towards COVID-19 booster doses among HCPs and identify the associated factors. Methods: A comprehensive search was conducted in the PubMed and Scopus databases from April to August 2024, using keywords related to COVID-19, vaccine hesitancy, HCPs, and booster vaccination. Studies that had been peer-reviewed, published in English after 2022, and focused on the hesitancy of the COVID-19 booster dose hesitancy among HCPs were included. Out of the 6703 studies screened, 24 studies were included. Results: Most of the HCPs have received their initial series of COVID-19 vaccinations. However, there is a lower rate of uptake for booster doses, with hesitancy rates ranging from 12% to 66.5%. Hesitancy rates varied significantly across continents, with Asia, Africa, and Europe ranging from 19.7% to 66.5%, 27% to 46.1%, 14% to 60.2%, respectively. Hesitancy was reported to be influenced by various factors, including concerns about vaccine safety, necessity, and effectiveness of these vaccines. In addition, the hesitancy regarding booster doses was also found to be influenced by factors like age, gender, profession, and previous COVID-19. Physicians, nurses, and pharmacists exhibited vaccine hesitancy rates ranging from 12.8% to 43.7%, 26% to 37%, and 26% to 34.6%, respectively. Conclusions: Our review underscores the hesitancy among HCPs towards receiving booster doses across countries around the world and explores the underlying factors. These findings provide valuable insights for the design of future pandemic vaccination programs.
Employee Management in Dairy Farms Associated with Bulk Tank Somatic Cell Count and New Mastitis Infection Risk
Authors: Farre Michael , Rattenborg Erik , Hogeveen Henk , Krömker Volker , Kirkeby Carsten Thure
Published: December 2024

For decades, bovine mastitis and milk quality have been a focus area for research, agricultural extension, and dairy processors worldwide, yet employee management as a factor in udder health management has received limited attention. This is mainly because the focus has previously been on more classical areas covered by the National Mastitis Council Mastitis Control Program (NMC 10-point plan) in English-speaking countries. Therefore, we wanted more background information on employee management on dairy farms, to identify the human factor of udder health management. The method of investigating employee management and the impact of employee management on udder health was conducting a study of 88 Danish dairy farms with hired employees and parlor or rotary milking systems. An interview-based questionnaire on individual dairy farmers’ human resource management was developed based on the current literature and multiple discussions among the authors. The results we found through analyzing associations between the dependent variable BTSCC and employee management, using a regression model, was that providing a generic SOP was associated with a 21,600 cells/mL increase in BTSCC, with estimates in the range (507; 42,674 cells/mL). We also analyzed, applying a Poisson model, that there was a 0.16% reduction in new infection risk if the training was based on a herd-specific SOP and educated employees. In contrast, we identified a 0.15% increase in new infection risk in herds where SOPs were available but not incorporated, both modest but significant results. In conclusion, farms with educated employees and trained by an SOP achieve the lowest new infection risk, but education has no impact on BTSCC.
Determination and Prediction of Available Energy in 13 Cereal Feed Ingredients for Growing Pigs
Authors: Zhao Jinbiao , Song Xiaoming , Yang Meiyu , Zhang Ge , Liu Ling
Published: December 2024

This study was conducted to develop equations to predict the digestible (DE) and metabolizable energy (ME) for growing pigs by using the chemical compositions of five corn, two wheat and six rice samples. A total of 13 castrated boars were chosen and fed 13 diets formulated with different cereal feed ingredients according to a 13 × 6 Youden square design. The DE and ME contents, the ratio of ME to DE, and the nutrient digestibility among the 13 cereal feed ingredients were different (p < 0.05), and the DE and ME ranged from 13.77 MJ/kg to 17.05 MJ/kg and 13.40 MJ/kg to 16.73 MJ/kg, respectively. The DE and ME were negatively correlated to the NDF (p < 0.10) and ADF (p < 0.05) contents among the test cereals; however, the DE and ME contents were positively correlated with the starch content. Based on the chemical analysis, the models for predicting the DE and ME in the cereal feed ingredients were DE (MJ/kg) = 0.1364 × Starch (%) − 0.2352 × ADF (%) + 11.4467 and ME (MJ/kg) = 0.9838 × DE (MJ/kg) − 0.0165 × CP (%) + 0.0538. In conclusion, the different chemical compositions of different cereal feed ingredients led to large variations in the energy concentration and digestibility of nutrients for growing pigs. The number of cereal samples needs to be further increased to improve the accuracy of the equations for predicting energy contents.
Application of Biomass Functional Materials in the Environment
Authors: Luo Yiting , Su Rongkui
Published: December 2024

With the intensification of global environmental issues, traditional materials science is facing unprecedented challenges [...]
The Attribution of Human Seasonal Influenza H3N2 Virus Detection to the Collector, Not Avian Sources, During the 2022 Highly Pathogenic Avian Influenza Outbreak in Pennsylvania, USA—Implications for Biosafety and Biosecurity
Authors: Tewari Deepanker , Sekhwal Manoj K. , Killian Mary L. , Zellers Corey , Nicholson Chrislyn Wood , Schroeder Betsy , Spackman Erica , Hamberg Alex
Published: December 2024

Highly pathogenic avian influenza (HPAI) surveillance for influenza A virus (IAV) in the United States is conducted using a National Animal Health Laboratory Network (NAHLN) real-time reverse transcriptase–polymerase chain reaction (rRT-PCR). Samples showing the presence of IAV are confirmed and characterized at the national reference laboratory. During the H5N1 HPAI outbreak in 2022, our laboratory reported the detection of IAV in a PA commercial chicken flock using rRT-PCR targeting the matrix gene, which was negative for the H5/H7 subtypes. IAV was not detected by additional sampling of the birds the following day with rRT-PCR. The virus detected was characterized as a human seasonal H3N2 with whole-genome sequencing (WGS). Further investigation revealed that the collector who visited the farm was diagnosed with an IAV infection. This case report emphasizes the importance of farm biosafety and biosecurity, of conducting regular reviews of worker safety protocols, and of advanced molecular techniques like WGS for viral characterization and epidemiology.
PENYULUHAN KESEHATAN MASYARAKAT MELALUI PEMERIKSAAN LABORATORIUM SEDERHANA SEBAGAI UPAYA PEMANTAUAN KESEHATAN MANDIRI
Authors: Sugiarti Mimi , Hartanty Hartanty , Dinutanayo Wimba Widagdho , Purnomo Agus , Nurminha Nurminha , Chaniago Yusrizal , Amien A. Zakaria , Djayasinga Rodhiansyah
Published: December 2024

Jumlah kasus penyakit tidak menular di Indonesia terus meningkat setiap tahunnya. Kejadian tersebut bisa diakibatkan karena kurangnya kesadaran individu dalam masyarakat untuk melakukan pemeriksaan kesehatan rutin, sehingga deteksi dini Penyakit Tidak Menular (PTM) berbasis pelayanan kesehatan menjadi kurang efektif. Penanggulangan faktor resiko PTM dan pencegahan berbasis masyarakat menjadi salah satu solusi yang dapat dilakukan untuk menekan resiko atau angka kematian akibat PTM. Tujuan kegiatan ini adalah melakukan pemeriksaan kesehatan berupa skrining kadar glukosa darah, asam urat, dan hemoglobin kepada masyarakat di lingkungan LKSA Panti Asuhan Sholawatul Fallah, Bandar Lampung. Waktu pelaksanaan yaitu Jumat, 26 Agustus 2022 bertempat di LKSA Panti Asuhan Sholawatul Fallah, Bandar Lampung. Kegiatan ini diikuti oleh 43 warga yang melakukan pemeriksaan kadar glukosa darah, asam urat, dan hemoglobin. Hasil yang diperoleh bahwa sebanyak 43% memiliki kadar glukosa darah yang tinggi, 28% memiliki kadar asam urat yang tinggi, dan 10% dengan hasil hemoglobin di bawah normal. Hasil pemeriksaan tersebut disarankan untuk pemeriksaan lanjutan ke Puskesmas bagi Masyarakat dengan kadar glukosa darah dan asam urat yang tinggi.
UPAYA PREVENTIF PENYEBARAN TUBERKULOSIS MELALUI PEMBERDAYAAN MASYARAKAT DALAM MENGOLAH DAUN KELOR SEBAGAI SPRAY DESINFEKTAN DI RT 02 RW 02 KELURAHAN PASIRKALIKI, KECAMATAN CIMAHI UTARA, KOTA CIMAHI
Authors: Abror Yogi Khoirul , Merdekawati Fusvita , Juliastuti Aditya
Published: December 2024

Penyakit tuberkulosis (TB) masih menjadi masalah kesehatan global, termasuk di Indonesia yang menempati peringkat kedua kasus TB terbanyak di dunia. Penularan TB yang mudah melalui droplet di lingkungan padat berkontribusi pada tingginya angka kejadian TB. Salah satu upaya pencegahan adalah dengan meningkatkan kebersihan lingkungan menggunakan desinfektan. Namun, desinfektan berbahan kimia seringkali meninggalkan residu, sehingga diperlukan alternatif berbahan alami, seperti daun kelor (
Moringa oleifera
), yang memiliki potensi antibakteri. Kegiatan pengabdian masyarakat ini bertujuan meningkatkan pengetahuan dan keterampilan kader Posyandu Mawar 01 dan 02 di RT 02 RW 02 Kelurahan Pasirkaliki, Kecamatan Cimahi Utara, dalam mengolah daun kelor sebagai spray desinfektan untuk mencegah penularan TB. Kegiatan meliputi persiapan, penyuluhan, pendampingan,
pre-test
, dan
post-test
. Media bantu seperti
powerpoint, leaflet
, video, serta produk spray desinfektan daun kelor dibagikan kepada kader untuk edukasi lebih lanjut. Hasil menunjukkan adanya peningkatan pengetahuan kader sebesar 42%, dengan rata-rata nilai
post-test
mencapai 85 dibandingkan nilai
pre-test
60. Kegiatan ini terbukti efektif dalam meningkatkan pemahaman kader mengenai pencegahan TB melalui penggunaan bahan alami. Diharapkan, kegiatan serupa dapat dilakukan secara rutin untuk meningkatkan kesadaran dan kemampuan masyarakat dalam pengendalian TB.
Litígios pueblerinos nos confins do Paraguai colonial: o paradigma do conflito entre reduções jesuíticas
Authors: Maurer Rodrigo
Published: December 2024

Este artigo contextualiza a província do Paraguai entre os séculos XVII e XVIII tendo como considerações principais narrativas históricas que, por alguma circunstância, indiquem situações de conflito pueblerino como indisposições entre reduções jesuíticas de modo a reivindicar títulos de terras, revisões sobre territórios mal definidos ou por cabeças de gado. Expostos dessa maneira, e por mais inusitados que tenham sido os desfechos, os episódios de litígios nos permitem conhecer melhor certas características regionais, oposições e defesas de identidades locais. Finalmente, revelam um esforço incessante por parte daSocietas Jesu em interferir na memória ancestral dos povos originários no sentido de “ajustá-la” conforme medidas que os religiosos julgavam apropriadas quando ainda, necessárias de aplicação.
Der Begriff der epistrophé bei Proklos, Damaskios und Dionysios Pseudo-Areopagita: Eine vergleichende Untersuchung
Authors: Kiria Ana
Published: December 2024

Der vorliegende Artikel untersucht den philosophischen Begriff der epistrophé im ursächlich-metaphysischen Kontext. Die epistrophé bildet das letzte Element der berühmten neuplatonischen Trias von moné, próodos und epistrophé (Verharren, Hervorgang und Rückwendung). Das zentrale Ziel dieser Arbeit ist es, den Begriff der epistrophé bei Proklos, seinem paganen Nachfolger Damaskios und Dionysios Pseudo-Areopagita, dem wirkungsmächtigsten christlichen Rezipienten von Proklos, vergleichend zu untersuchen. Beide Denker bewegen sich in unterschiedlicher Abhängigkeit von der Philosophie des Proklos, die ihre Grundlage darstellt, und entwickeln gleichzeitig ihre eigene Autonomie. Die vergleichende Analyse des Begriffs der epistrophé dient auch dazu, die Eigenheiten dieser drei Denker herauszuarbeiten und die komplexen Beziehungen zwischen ihnen aufzuzeigen. Der Artikel beginnt mit einer Darstellung des Proklischen Begriffs der epistrophé, wobei besonders auf seine Theologische Grundlegung Bezug genommen wird. Anschließend wird auf die Kapitel 75-77 von Damaskios’ Aporien und Lösungen bezüglich der ersten Prinzipien eingegangen. Damaskios thematisiert hier einige Probleme und Schwierigkeiten, die den neuplatonischen Begriff der epistrophé betreffen und sich aus Proklos’ Formulierungen ergeben. Durch seine Problemstellungen klärt und vertieft er den von Proklos geprägten Begriff der epistrophé, wobei seine Grundanschauung im Wesentlichen mit der des Proklos übereinstimmt. Im Gegensatz dazu erfolgt bei Dionysios eine Neuinterpretation des Begriffs der epistrophé. Um Dionysios’ Transformation des Begriffs zu verdeutlichen, werden drei Schlüsselstellen aus dem Werk Über göttliche Namen ausführlich analysiert. Dabei werden auch relevante Passagen aus dem späten Neuplatonismus und der Patristik herangezogen. Hierdurch wird gezeigt, dass Dionysios den Begriff der epistrophé vom Ontologischen ins Christlich-Soteriologische umdeutet. Auf diese Weise überschreitet er die neuplatonische triadische Kausalstruktur und entwickelt eher eine Tetrade, in der die epistrophé bereits als apokatástasis verwendet und mit der Totenauferstehung verbunden wird. In diesem Zusammenhang wird auch der fundamentale Unterschied zwischen den Begriffen der epistrophé und der apokatástasis in Proklos’ Philosophie beleuchtet.
Leucemia Linfoblástica Aguda em Pediatria: Epidemiologia, diagnóstico, terapias-alvo e desafios no tratamento
Authors: Gripp Isabella Morais , Nacari Ana Luisa Fava janetti , Faria Iris Lopes de , Freitas João Pedro Berbert , Maciel Jully Belluzzo Silva , Coutinho Maria Clara Carvalho , Jorge Nair dos Santos , Barra Pedro Henrique Nunes , Ranção Rafaela Werneck , Gomes Thaís Dilze Varginha
Published: December 2024

A leucemia linfoblástica aguda (LLA) é o câncer hematológico mais comum na infância, com uma incidência global significativa. Sua prevalência é mais alta em crianças, mas também pode ocorrer em adultos, com picos de incidência na infância e na idade adulta precoce. A doença caracteriza-se pela proliferação descontrolada de linfócitos imaturos, o que compromete a função normal da medula óssea e do sistema imunológico. O diagnóstico da LLA é realizado por meio de exames laboratoriais, como a análise do sangue periférico, mielograma e técnicas de imagem. A confirmação do diagnóstico depende da identificação de linfócitos blastos no sangue e na medula óssea, além de testes genéticos que podem identificar anomalias cromossômicas específicas. Nos últimos anos, o tratamento da LLA evoluiu consideravelmente, com avanços nas terapias-alvo e na utilização de terapias moleculares e imunoterápicas. A quimioterapia ainda é a base do tratamento, mas novas abordagens, como a terapia com células T CAR, oferecem melhores resultados, especialmente em casos refratários. O foco dessas terapias é atacar as células leucêmicas de maneira mais específica, minimizando os efeitos colaterais e aumentando as taxas de sobrevida. No entanto, apesar dos avanços, o tratamento da LLA ainda apresenta desafios, como as taxas de recidiva, especialmente nos pacientes adultos, onde a resposta ao tratamento é menos eficaz. A resistência ao tratamento e a presença de características genéticas adversas, como a deleção do IKZF1, complicam o manejo e pioram o prognóstico em alguns casos. Portanto, embora os avanços no diagnóstico e tratamento da LLA tenham sido notáveis, os desafios no tratamento das recidivas e na gestão dos casos mais complexos, especialmente em adultos, continuam a demandar esforços de pesquisa e novas abordagens terapêuticas. A personalização do tratamento, com base nas características moleculares do paciente, é uma das principais promessas para melhorar os resultados a longo prazo.
STRATEGI PENGEMBANGAN USAHA JENANG PASCA PANDEMI MENGGUNAKAN METODE SWOT DAN QSPM PADA CV. MUBAROKFOOD CIPTA DELICIA
Authors: Nasya Vilda Innaka , Arbainah Siti , Ardian Widiarto
Published: December 2024

This research is applied research with a qualitative descriptive case study approach that aims to formulate a business development strategy after the Covid-19 pandemic at CV. Mubarokfood Cipta Delicia. Data was collected using observation, interview, documentation, and questionnaire methods. Data analysis was carried out using the IFE, EFE, CPM, IE, SWOT, and QSPM matrices. The result of the total IFE weighted score is 2.789 and the total EFE weighted score is 3.358. The total score based on CPM of 3,413 shows that the company is in the most superior position. The results of the IE Matrix analysis are in quadrant II (grow and build) by producing integration strategies and intensive strategies, which are further processed using the SWOT matrix and create eight alternative strategies. The strategy that best suits the condition of the company based on QSPM is to maintain quality and increase product innovation through cooperation with suppliers to achieve customer satisfaction with a TAS value of 6.691.
PENGARUH EARNING PER SHARE DAN PRICE EARNING RATIO TERHADAP HARGA SAHAM PADA PT BANK CENTRAL ASIA Tbk PERIODE 2012-2022
Authors: Satria Rita , Sukmana Sri Rahmawati , Herlianti Elva , Nufzatutsaniah Nufzatutsaniah
Published: December 2024

This research aims to determine the influence of Earnings per Share (EPS) and Price Earning Ratio (PER) on Stock Prices at PT Bank Central Asia Tbk for the period 2012-2022. The research method employed is quantitative research with an associative type, and the population of the study comprises the financial reports of PT Bank Central Asia Tbk for the period 2012-2022. The data sample is derived from the Income Statement, Notes to the Financial Statements, and Summary of Stock PT Bank Central Asia Tbk for the period 2012-2022. Data analysis is conducted using SPSS Version 25, and the data testing includes Descriptive Statistical Test, Classical Assumption Test, Multiple Linear Regression Test, Correlation and Determination Coefficient Test, Partial Hypothesis Test (t-test), and Simultaneous Hypothesis Test (F-test). The results of the t-test in this study indicate that the Earnings per Share variable has a significant influence on Stock Prices, while the Price Earning Ratio variable also significantly affects Stock Prices. Meanwhile, the F-test results show that both the Earnings per Share and Price Earning Ratio variables simultaneously have a significant influence on Stock Prices, with a determination coefficient of 98.6%, indicating a strong relationship.
PENGARUH TOTAL ASSET TURNOVER, LEVERAGE DAN SALES TERHADAP PERTUMBUHAN LABA PADA PERUSAHAAN FOOD AND BEVERAGE YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Candradevi Astiani Nur , Alliyah Siti
Published: December 2024

This study aims to determine the impact of Total Asset Turnover, Leverage, and Sales on profit growth in food and beverage companies listed on the Indonesia Stock Exchange (IDX) during the period of 2019 - 2021. The sampling technique employed was purposive sampling, resulting in a sample size of 11 companies. For this study, the data analysis method employed is multiple linear regression analysis. The findings of this study indicate that Total Asset Turnover and Sales have a positive impact on profit growth, whereas Leverage has a negative impact on profit growth.
PENGARUH GREEN ACCOUNTING DAN SUSTAINABILITY REPORT TERHADAP KINERJA KEUANGAN PERUSAHAAN (STUDI PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BEI)
Authors: Viona Adikasiwi  , Widiatmoko Jacobus , Indarti MG Kentris
Published: December 2024

The research was conducted to test and analyze whether green accounting projected with index proper while sustainability reports projected by corporate social responsibility influenced the financial performance of companies with leverage and size of companies as controlling variables. The research objects used are manufacturing companies listed on the Indonesian Stock Exchange from 2018 to 2022. The sampling technique in this study uses purposive samplings with defined criteria, thus producing 249 data. The method used in this study is the double linear regression analysis method. The results of this research show that green accounting and sustainability reports have an impact on the financial performance of companies.
PENGARUH KOMPETENSI, INDEPENDENSI, FEE AUDIT AUDITOR DAN TIME DEADLINE PRESSURE TERHADAP KUALITAS AUDIT
Authors: Rahati Devi Ayustine  , Srimindarti Ceacilia
Published: December 2024

Hasil dari kualitas audit sangat penting bagi suatu entitas, hal ini dikarenakan hasil audit dapat memberikan suatu keyakinan yang tinggi terhadap infomasi laporan keuangan entitas tersebut. Tujuan dari penelitian ini adalah untuk menguji adakah pengaruh kompetensi, independensi, fee audit, serta time deadline pressure terhadap kualitas audit yang disajikan auditor untuk kepentingan entitas. Pengumpulan data pada penelitian ini dengan membagikan kuesioner kepada para auditor yang bekerja pada Kantor Akuntan Publik di Kota Semarang.  Dengan mengunakan sampel penelitian sebanyak 78 auditor. Kemudian data akan diolah menggunakan SPSS 22. Hasil dari penelitian ini menunjukan bahwa kompetensi, independensi dan time deadline pressure berpengaruh positif terhadap kualitas audit. Sedangkan fee audit tidak berpengaruh terhadap kualitas audit.
Kata kunci: kompetensi, independensi, fee audit, time deadline pressure, kualitas audit
ENVIRONMENTAL COST ACCOUNTING TREATMENT IN PHARMACEUTICAL COMPANIES (A STUDY OF PT. SUMBER OBAT MALANG)
Authors: Putri Syehryl Meidiana , Alamsyah Ahmad Fahrudin
Published: December 2024

This study aims to determine the accounting treatment of environmental costs in waste management efforts at PT Sumber Obat related to the process of identification, recognition, measurement, presentation, and disclosure of environmental costs. This research uses qualitative research methods with a case study approach. The results showed that PT Sumber Obat has carried out waste management very well and also pays attention to its responsibility to the surrounding community by holding CSR programs. In the application of environmental accounting, there are five stages of cost allocation. The identification stage is classified into 2 costs, namely operational costs (repair costs, maintenance costs, employee bonus salaries, chemical decomposition costs, administrative and general costs, donation costs) and environmental and AMDAL handling costs. The environmental cost recognition stage uses the accrual basis method which recognizes when transactions occur without reference to cash transfers. The measurement stage of environmental costs is by PSAK which uses rupiah units and uses the historical cost method. The presentation stage of environmental costs has not been separated from the financial statements and is made one with the company's operating costs included in the income statement. The disclosure stage shows that PT Sumber Obat has not disclosed related environmental cost reports, and there are no policies and notes related to environmental costs in the notes to the financial statements.
PENGARUH KUALITAS AUDIT, KEKUATAN PENDAPATAN, KOMITE AUDIT TERHADAP NILAI PERUSAHAAN
Authors: Juli Supriyatno Dwi Retno Setianingrum , Hendrani Ai
Published: December 2024

Company value offers investors a framework to evaluate investment choices. The goal of the purpose of this research is to examine the impact of audit quality, revenue strength, and audit committee about the matter value of enterprises operating in the fundamental industrial and chemical domains that are listed on the Indonesia Stock Exchange (BEI) from 2020 to 2022. This research paradigm employs a causal design using secondary data sources. The sampling technique used was purposive sampling, including a selection of 32 firms over a span of 3 years. This yielded a total of 96 samples, namely in the form of annual report data from companies operating in the basic industrial and chemical sectors over the period of 2020-2022. This study employs a quantitative methodology by doing statistical analyses on the data. It utilizes research analysis techniques such as descriptive statistical analysis tests, classical statistical hypothesis testing, and conducting hypothesis testing via the use of multiple linear regression method. The study results suggest that the variable of audit quality has a substantial significant and advantageous effect on the company's valuation. The earnings power and audit committee variables have no impact the value of a firm
DETERMINAN TERHADAP KEPATUHAN WAJIB PAJAK MELALUI INFORMASI PERPAJAKAN SEBAGAI PEMODERASI
Authors: Anita Anita Silvia Rahayu , Badjuri Achmad
Published: December 2024

The purpose of this research is to assess the use of e-filing, tax socialization, and tax knowledge on taxpayer compliance with tax information as a moderating variable for taxpayers at the West Semarang Pratama Tax Service Office (KPP). This research uses quantitative methods. This method uses a questionnaire as the basis for data collection. The population used in this research is Taxpayers registered at the West Semarang KPP. The sampling method used was purposive sampling with the criteria of taxpayers registered at the West Semarang KPP and using the e-filling application. In this research, the data analysis method used is Moderated Regression Analyze (MRA). The results of this research are that the use of e-filing and tax socialization has no effect on taxpayer compliance, but tax knowledge has a positive effect on taxpayer compliance, and tax information is not able to moderate the relationship between the use of e-filing, tax socialization, and tax knowledge on taxpayer compliance.
PENGARUH KINERJA KEUANGAN DAN KINERJA LINGKUNGAN TERHADAP NILAI PERUSAHAAN DENGAN KEPEMILIKAN MANAJERIAL SEBAGAI VARIABEL MODERASI
Authors: Firmanda Alfifa Ayu , Wahyuni Nanik
Published: December 2024

The purpose of this study was to determine the effect of financial performance and environmental performance on firm value and managerial ownership as a moderator between financial performance and environmental performance on firm value. This study uses a quantitative approach with a purposive sampling technique. The results showed that the EVA value was 0.8075> 0.05, the MVA value was 0.5351> 0.05, the environmental performance value was 0.0151 <0.05, and the KM value between EVA and firm value was 0.7839> 0.05. The KM value between MVA and firm value is 0.0095 < 0.05, while the KM value between environmental performance is 0.6758 > 0.05. Thus, EVA and MVA do not affect firm value, while environmental performance has a significant effect on firm value, and managerial ownership as a moderating variable does not moderate the effect of EVA, and environmental performance on firm value. However, managerial ownership can moderate the relationship between MVA and firm value.
Studi Pengendalian Persediaan Bahan Baku Rotan di Desa Taba Pasemah Kabupaten Bengkulu Tengah
Authors: Idsan Rakha Satya
Published: December 2024

Penelitian ini bertujuan untuk mengevaluasi proses pengendalian persediaan bahan baku rotan pada usaha Rafflesia Rotan dan Sri Rotan, meliputi kuantitas pemesanan per batch, kuantitas safety stock, reorder point untuk pemesanan ulang, serta total biaya persediaan. Penelitian ini menggunakan metode analisis deskriptif kuantitatif, dengan objek penelitian adalah usaha Rafflesia Rotan dan Sri Rotan. Data yang digunakan mencakup data primer dan sekunder. Analisis data dilakukan menggunakan metode EOQ, analisis safety stock, analisis reorder point, dan analisis total biaya persediaan (total cost). Berdasarkan hasil analisis, kuantitas pembelian optimal per pesanan pada usaha Rafflesia Rotan adalah 495-500 batang, dengan kuantitas safety stock sebesar 180-196 batang. Reorder point ditetapkan pada 207-226 batang, dan total biaya persediaan sebesar Rp.42.539.799,1-Rp.45.333.881,2 per tahun. Sedangkan pada usaha Sri Rotan, kuantitas pembelian optimal per pesanan adalah 534-631 batang, dengan kuantitas safety stock sebesar 55-88 batang. Reorder point berada pada 71-101 batang, dan total biaya persediaan sebesar Rp.13.347.818,6-Rp.15.790.625 per tahun.
Forecasting Using the Time Series Forecasting Model at SMEs Pempek Dang Tirta, Banyumas, Central Java
Authors: Firmansyah Firmansyah , Fatharani Arina , Anis Ulfah
Published: December 2024

Erratic product demand makes manufacturers create strategies to minimize unsold products. Products that are stored for a long time can cause losses, so forecasting is needed to calculate future product demand. The method used in this study uses a time series forecasting model at SMEs Pempek Dang Tirta. The quantitative data used covers the period January 2022-August 2023. The results of the calculation of the naïve bayes, exponential smoothing, Simple Moving Average (SMA), and Least Square models are presented in the table. The MAD (Mean Absolute Deviation) value indicates that the average deviation of the yb data from its mean value is about 1060.82 and The least square value obtained is 306.44 indicating that it could be the constant or intercept value of the resulting regression model.
Analisis Daur Hidup Usahatani Jagung Pakan Dengan Mekanisasi Terhadap Gas Rumah Kaca (GRK) Di Desa Tambang Ulang, Kalimantan Selatan
Authors: Darmawan Muhammad Indra , Ilmannafian Adzani Ghani , Kiptiah Mariatul , Mawardi Muhammad Ikhsan
Published: December 2024

The development of maize agricultural in Indonesia continues to increase. Along with this, the potential risks in environmental aspects as GHGs will be even greater. The purpose of this study is to identify and measure GHGs in each process flow of maize agriculture and provide recommendations for efficient mitigation efforts against environmental impacts generated by maize agriculture with a semi-automatic system in Tambang Ulang village. The research method used is field research in Tambang Ulang Village with LCA analysis carried out in four stages, definition of objectives and scope, input and output inventory analysis, environmental impact analysis of inventory, and interpretation of results. GHG measurements are carried out using emission factors and energy coefficients, calculations based on the guidelines of the Intergovernmental Panel on Climate Change. The results showed that the GHG emissions produced in the production per ton of maize were 401.12 kg CO2 eq. The largest GHG emissions are produced by urea fertilization with emissions of 51.38% of the total emissions produced. Mitigation recommendations that can be done to reduce GHG emissions are using types of manure with less N amounts and reducing the use of chemical fertilizers; adding organic fertilizers that are more environmentally friendly; and using legume cover crops and N-fixing bacteria as environmentally friendly N sources.
Analisis Karakteristik Fisik Kopi Arabika Sidamanik Proses Pengolahan Full Washed Berdasarkan Variasi Teknik Penyangraian
Authors: Mulyara Budi , Alwi Annisa Lutfi , Kusumaningtyas Rizky Nirmala
Published: December 2024

Arabica coffee stands as a prominent commodity within the plantation sector, with Sidamanik Arabica coffee from Simalungun Regency, North Sumatra, showing promise for further development. Utilizing a full-washed process, which involves wet post-harvest coffee processing using water in various stages to enhance bean quality, is essential. It is imperative to uphold the quality of dry coffee beans during the roasting stage to ensure the sensory quality. The study aims to ascertain the physical characteristics of Sidamanik full-washed Arabica coffee roasted using three different techniques, incorporating initial temperatures of 170oC, 180oC, and 190oC, and a horizontal drum type machine comprising 7 mm Cast Iron material and 4 mm Food Grade Stainless Steel. Each treatment was replicated three times, and the observed variables encompassed triage value (SNI 01-2907:2008), density of green beans and roasted beans (g/cm3), and percentage of weight loss (%) of roasted beans. The data underwent analysis using the ANOVA test to determine significance, with the subsequent application of the Duncan Test at the 5% level in the presence of significant differences. The percentage of defects identified in Sidamanik Arabica coffee beans amounted to 12.33%. Furthermore, the total defect value of Sidamanik Arabica green beans was categorized as quality 3, with a total defect value of 35.7. Notably, the density value in roasted beans was higher when utilizing the Cast Iron (CI) drum type in comparison to other drum types.