bluuebunny/crossref_metadata_2025 huggingface dataset:
Territorial pattern between outbreaks of ASF among wild and domestic pigs in Ukraine
Authors: Dudnyk Ye. O.
Published: January 2022

The article presents the results of the analysis of the epizootic situation in Ukraine regarding African swine fever among domestic and wild pigs from 2012 to 2020 and identifies the main sources of virus spread as well as weak links in the biological safety system of farms. When studying the statistical material of the Food and Agriculture Organization of the United Nations (FAO) and the State Service of Ukraine on Food Safety and Consumer Protection regarding animal morbidity, revealed a territorial pattern between the outbreaks of African swine fever among wild boars and domestic pigs of private farms and pig-breeding complexes, and proved the involvement of the European boar in the epizootic process as a natural reservoir and mobile focus of infection. Calculated the number of outbreaks of African swine fever among wild boars and domestic pigs within the same region and district, and studied the sequence of the emergence of foci on limited territories. Analyzed the natural focality of the disease, the probability of infection transmission to the domestic pig farm sector, and the role of infected objects in the spread of the virus among wild animal populations. From 2012 to 2020 inclusive, according to FAO statistics, 537 cases of African swine fever were recorded in Ukraine, 21.7 % of which were associated with wild boars. In 2017 and 2018, the role of the European wild boar in the epizootic process is best reflected, when 10.9 % (2017) and 20.4 % (2018) of outbreaks of African swine fever among domestic animals recorded in the same administrative districts, where during a year this desiase was detected among wild pigs. When analyzing statistical data of the recent years, the effectiveness of introducing more detailed monitoring of African swine fever among wild boars using modern laboratory methods and improving biosafety measures in the private sector and directly on hunting grounds has been proved. Further research is based on predicting the dynamics of the spread of African swine fever in Ukraine and the role of wild boar in this epizootic process. In addition, the role of wild boar in the spread of African swine fever in other countries and the most effective foreign methods of disease control and prevention will be analyzed.
Immune status of young pigs different methods of their breeding using means Globigen® Pig Doser and Globigen® Jump Start
Authors: Krempa N. Y. , Kozenko O. V. , Chornyj M. V. , Gutyj B. V. , Martyshuk T. V.
Published: January 2022

The article deals with the influence of the use of means for young pigs Globigen® Pig Doser та Globigen® Jump Start, which due to the content of specific Ig Y have immunostimulatory properties. Assessing the level of nonspecific resistance of piglets, which are based on determining the content of T- and B-lymphocytes and their populations in the blood of animals 30-, 60- and 120-day-old, the trend of increasing the number of T-helpers, T-natural killers and B-lymphocytes in the experimental groups of animals of both farms. It was found that the content of T-helpers during single-phase rearing of pigs became more important under the action of Globigen® Pig Doser and ranged from 30.16−35.15 %, and during three-phase rearing – under the action of Globigen® Jump Start 34.58−35.08 %. An increase in the content of B-lymphocytes to the level of physiological norm was noted: FE PE “Glynjany Agro” (single-phase cultivation) in the first experimental group 16.75–19.45 %, in the second 17.66–21.11 %. At Ltd. “Meat Resources” (three-phase cultivation) 17.7–21.02 % and 18.91–21.01 %, respectively, in the first and second experimental groups. Regarding the indicators of the content of T-natural killers, there is a tendency to increase their number in the blood of animals of experimental groups by an average of 4.90 % for single-phase rearing and 3.09 % for three-phase rearing of pigs. Such data give grounds to claim that there is a formation of the immune response to the action of pathogens, which plays an important role in maintaining the barrier function of the intestinal mucosa, which in turn reduces mortality and increases the average daily gain of young pigs. Under the action of immunostimulants, the safety of piglets in FE PE “Glynjany Agro” (single-phase rearing) at 30 days of age increased to 81.3−93.7 %, and in Ltd. “Meat Resources” (three-phase rearing) to 80.0−86.7 %. In piglets FE PE “Glynjany Agro”, up to 120 days of age, the average daily gain was 0.710 and 0.691 kg using Globigen® Pig Doser and Globigen® Jump Start, and in piglets from Ltd. “Meat Resources” these figures were 0.595 and 0.628 kg.
Research Progress on the pathogenic mechanism of Streptococcus suis 2
Authors: Liu Mingcheng , Xia Xiaojing , Liu Xingyou , Kasianenko Oksana
Published: January 2022

Streptococcus suis (S.suis) is an important zoonotic pathogen that can cause many diseases in pigs, such as sepsis, arthritis, endocarditis, and meningitis, of which meningitis is the most serious. There are 35 serotypes, and serotype two is the most virulent. At the same time, Streptococcus suis serotype 2(SS2) can also infect humans, causing severe public health problems. Although SS2 has attracted significant attention worldwide, the research on its pathogenesis is still limited. The adhesion of pathogenic bacteria to the surface of host cells or tissues and its subsequent invasion and diffusion are the critical steps of pathogenic bacteria. Moreover, the interaction between pathogen and host is involved in these processes. Therefore, to study the pathogenic mechanism of pathogenic bacteria is to study the interaction between pathogenic bacteria and host. This paper described several common virulence factors, such as CPS, SLY, MRP, EF, SAO, Srt, FBPS, SadP, and Eno. Under the actions of virulence factors, SS2 adheres and colonizes to the mucosal and epithelial surface of host cells. Then SS2 invades into deeper tissues and bloodstream. If SS2 in the blood does not cause fatal sepsis, It can go to the third stage. The third stage is to cross the BBB and access the CNS and ultimately causes meningitis. During pathogenesis, SS2 interacts with multiple host cells, such as neutrophils, macrophages, epithelial cells, and microvascular endothelial cells to evade the innate or adaptive immunity of the host.
Bacterial contamination of chicken food egg with automated and manual sorting and packaging
Authors: Demyanenko D. V. , Vashchyk Ye. V. , Fotina T. I.
Published: January 2022

Chicken eggs are a staple food for humans and are consumed all over the world. Chicken eggs have a leading position among food products in terms of nutritional value and taste. During storage, under the influence of air oxygen and microorganisms, eggs deteriorate, contamination of opportunistic and pathogenic microflora increases. Purpose: analysis of the results of bacteriological studies of eggs of various producers during automatic and manual sorting and packaging from the trading network in Sumy and the Sumy region in accordance with DSTU 5028:2008 “Edible hen eggs. Specifications” and Microbiological Criteria for Establishing Food Safety Indicators. Materials and methods. Bacteriological studies of shell washings and egg contents were carried out according to standard methods. Samples of edible chicken eggs with automatic and manual sorting and packaging corresponded to DSTU 5028:2008, Microbiological criteria for establishing food safety indicators and BIE No. 5061-89. Pathogenic and opportunistic pathogens of bacterial diseases were not isolated from the surface of eggs of the control group during automated sorting and packing, spore bacteria of the genus Bacillus (Bacillus subtilis) were isolated. In washes from the egg shell surface with manual sorting and packaging, Streptococcus spp was found – 12 % of the number of samples examined, E. faecalis – 34 %, P. aeruginosa – 11 %, and spore bacteria of the genus Bacillus (B. subtilis) – 43 %. The number of QMA&OAMO and CGB (coli-forms) in both groups corresponded to the established norms, but the QMA&OAMO indicator in the products of enterprises with manual collection and packaging was 34 % higher compared to eggs from enterprises with automated sorting and packaging. Automation of the process of sorting and packing eggs provides the best microbiological indicators of the safety of edible hen eggs in comparison with those when using manual labor during sorting and packing. A complete transition to the automation of production processes for the production of edible eggs in Ukraine is required.
Treatment of postoperative wounds using pectin-based reinforced dressings and their antimicrobial activity
Authors: Vlizlo V. , Mysak A. , Stybel V. , Voloshyn R. , Leno Yu. , Kuz'mina N. , Kozak M. , Bodnar Yu. , Petpuh I. , Ostapiv D. , Dron I. , Samaryk V. , Bukartyk N. , Nosova N. , Varvarenko S.
Published: January 2022

A reinforced pectin-based dressing with a reinforcing element containing the antimicrobial agent chlorhexidine bigluconate has been developed. In vitro studies have shown that the hydrogel pectin dressing containing 0.03 ÷ 1.5 % chlorhexidine bigluconate inhibits the growth of both gram-positive (S. aureus) and gram-negative (P. aeruginosa) bacteria. The dressing can be used in the complex treatment of postoperative wounds with infectious-inflammatory process. The efficacy of different doses of chlorhexidine bigluconate was characterized by growth inhibition and increase of microorganism-free areas on the culture medium around the site of dressing localization, and regardless of the type of bacteria. Bacterial growth inhibition radius size depends on the dose of chlorhexidine in the hydrogel pectin dressing. The inhibition of growth of S. aureus and P. aeruginosa is directly proportional to chlorhexidine bigluconate content. The increase of dressing saturation with chlorhexidine to 1.0 and 1.5 % recorded the maximum inhibition of the growth of microorganisms. A veterinary clinical trial has shown a good therapeutic effect in the wound healing, in particular in the complex treatment of postoperative and accidental wounds both in the presence of infectious-inflammatory process and in its absence. The reinforced pectin-based dressing with cotton (or polypropylene) reinforcement element containing chlorhexidine bigluconate reduces the cost of dressings and bandaging frequency during wound healing. It protects the wound surface from contamination, mechanical irritation, bacterial contamination and the development of secondary infection. The dressing promotes good water, air and heat exchange between the wound and the environment, adsorbs excess exudate, maintains a moist environment and does not cause hyperosmotic damage and drying of the wound. Surgical wound healing occurred under the initial tension for 7 days. Considering the method of its application, this dressing is suitable for use on different parts of the animal's body (neck, withers, chest and abdomen, lower back, buttocks, thighs, shoulders, etc.).
Influence of probiоtic additive “Evitalia” on growth and blood indices of quails
Authors: Cherniy N. , Skvortsova I. , Gutyj B. , Mylostyvyi R. , Voronyak V.
Published: January 2022

The results of the studies on the determination of the optimal dose of the probiotic additive “Evitalia” (PAE) for the quails of the Texas breed have been presented in the article. The experiments were conducted on the quails aged 1–35 days. The object of the research was the probiotic additive “Evitalia” that consisted of eight components (the strains of lactic acidmicroorganisms, macro- and microelements). The subject of the investigation was the influence of PAE on the growth, preservation, the morphological composition and biochemical indices of blood. The studies were carried out in the following conditions of microclimate and sanitary regime: the air temperature in the pens-cages was 16–18 ºC in the autumn and winter period that was 5–7 ºC lower than it was provided by the standard; in spring the temperature was 23–15 ºС that was lower than it was provided by the standard (29–35 ºС). The concentration of carbon dioxide ranged within 0.20–0.25 % (2.0–2.5 l/m3), ammonia – 12–13.4 mg/m3, the general contamination of the air by microflora was 50–60 thousand KOE/m3. The experiments were conducted on the four groups of quails, 60 quails in each group. The quails of the control group were fed by water without PAE, the probiotic at the dose of 7 mg/500 ml of water was given to the quails of the experimental group 1 (E-1), 9 mg of probiotic/500 ml water received the birds of the experimental group 2 (E-2) and the quails of the experimental group 3 (E-3) were given the probiotic at the dose of 11 mg/500 ml water. The positive influence of the probiotic additive “Evitalia” on the growth and the body live weight gain of the quails was observedin the experimental groups as compared to the quails of the control group. The trustworthy increase in the growth and live weight gain of the quails was detected on the 7-, 14-, 21-, 35-day of their life (Р < 0.05), especially in the quails that received PAE at the dose of 9 mg (E-2). The quails of the experimental group 2 exceeded the others by the average daily live weight gains. The growth intensity of the quails in the experimental group 2 was 6.43 % higher than that of the control one, higher by 3.47 % and 5.57 % than in the experimental groups 1 and 3, respectively. The preservation of the quails in the control group was lower by 4.8 – 5.1 % as compared to the quails in the experimental groups. By the data on the growth of the body live weight, the composition and biochemical indices of blood of the quails it can be concluded that the optimal dose of the probioticadditive “Evitalia” is 9 mg/500 ml water that activates hematopoesis and stimulates the growth and development of quails.
The peculiarities of hormonal background in boars under correction of reproductive capacity by gadolinium orthovanadate nanoparticles
Authors: Koshevoy V. I. , Naumenko S. V. , Klochkov V. K. , Yefimova S. L.
Published: January 2022

Determination of the influence of redox nanomaterials on the body of males is of great interest to researchers, because the basis of the pathogenesis of male infertility is oxidative stress. A necessary condition in the development of such drugs is the absence of toxic effects on sexual function. It has been proved that nanomaterials based on oxides of rare earth elements have a positive effect on reproductive capacity and, at the same time, they are not gonadotoxic. A comprehensive approach is of particular importance in order to justify their use as a means of reproductive capacity correction. Taking into account the toxicity parameters the mechanisms of their action need to be studied at the biochemical, morphological and clinical levels. The positive effect of gadolinium orthovanadate nanoparticles on the quality of boar sperm (especially in terms of motility and the number of motile sperm in the ejaculate) with an effective reduction of the oxidative load on the body have been shown. The aim of this study was to determine the effect of these nanoparticles on the hormonal background of males with a decreased reproductive capacity under oxidative stress. Thus, the administration of hydrosol of gadolinium orthovanadate nanoparticles for 14 days revealed a normalization of sex hormones – an increase in total testosterone, in particular, on the 15th day of the study – by 22.6 % (P ˂ 0.01), and on the 30th day – by 77.4 % (P ˂ 0.001) compared with the group of animals before the administration. There was a decrease in the level of 17β-estradiol on the 30th day – by 25.0 % (P ˂ 0.01), which almost reached the values of the control group. A decrease in the content of globulin testosterone-estradiol-binding in boars of the experimental group, in particular, on the 15th day of the experiment – by 13.0 % (P ˂ 0.05), and on the 30th day – by 26.8 % (P ˂ 0.001) was determined, which, in turn, led to an increase in androgen saturation of the animal body – the index of free androgens at the end of the study was 43.2 %. The results are explained by the properties of the nanoparticles. Correcting oxidative stress, they increase the antioxidant potential, thereby normalizing the activity of endocrine glands and ways of regulating the germ-endocrine function of the gonads. The prospect of further research is to elucidate the effect of the correction of decreased reproductive capacity in boars under oxidative stress by nanoparticles of oxides of rare earth elements on the morphological state of the gonads.
АНТИКРИЗОВЕ УПРАВЛІННЯ ЯК ІНСТРУМЕНТ ЗАБЕЗПЕЧЕННЯ ЕКОНОМІЧНОЇ СТІЙКОСТІ ПІДПРИЄМСТВА В УМОВАХ ПАНДЕМІЇ COVID-19
Authors: Бірбіренко Світлана , Орлов Василь , Мокруха Наталя
Published: January 2022

Стаття присвячена визначенню сутності та змісту категорії «антикризове управління» як інструменту забезпечення економічної стійкості підприємства, яке функціонує у кризових умовах, спричинених впливом пандемії COVID-19. Встановлено, що наявність криз обумовлюють необхідність розробки і застосування виняткових управлінських підходів для забезпечення своєчасного початку боротьби з розвитком кризових процесів на підприємстві з метою збереження і відновлення своєї економічної стійкості. Сформовано авторське визначення антикризового управління економічною стійкістю підприємства. Визначено, що ефективність антикризового управління економічною стійкістю підприємства залежить від комплексності та повноти його використання, організації взаємодії усіх елементів системи управління, адекватності використовуваних методів їх оцінювання та діагностики кризових процесів.
ANALISIS KEPERLUAN PEMBANGUNAN AMALI BERASASKAN RASPBERRY PI TOPIK ELEKTRIK PROGRAM MATRIKULASI
Authors: Abdullah Aslindawati , Yap Abdullah Nurul Syafiqah , Yaacob Mohd Ikhwan Hadi
Published: January 2022

Kajian analisis keperluan ini memberi fokus kepada kepentingan membina alat sokongan pengajaran dan pembelajaran makmal yang boleh diaplikasi secara berfokus terhadap objektif dan keperluan kumpulan sasaran. Dalam kajian analisis keperluan bagi pembangunan modul amali RASPHY, penentuan punca masalah dan topik yang paling sukar merupakan fokus utama bagi memastikan modul yang dihasilkan membantu pelajar dan pensyarah dalam pembelajaran subjek fizik di kolej matrikulasi. Seramai 203 orang responden yang terdiri daripada 173 pelajar dan 30 pensyarah fizik dari semua kolej matrikulasi Kementerian Pendidikan Malaysia terlibat dalam kajian analisis keperluan ini. Dapatan kajian ini mendapati majoriti responden setuju bahawa amali fizik yang dijalankan secara konvensional memerlukan pembaharuan untuk meningkatkan kefahaman dan minat mereka dalam menjalankan amali secara lebih optimum. Selain itu topik yang paling sukar yang menjadi pilihan utama responden adalah topik Elektrik iaitu topik ke tujuh belas dalam sukatan pelajaran fizik program matrikulasi. Dengan pembangunan modul amali RASPHY yang menggunakan teknologi Raspberry Pi adalah diharapkan dapat membantu pelajar dan pensyarah dalam meningkatkan pencapaian, sikap terhadap STEM dan minat pelajar matrikulasi dalam topik Elektrik.
KEBERKESANAN KEMAHIRAN FASILITASI GURU DAN BREAKOUTS ROOM BAGI KAEDAH PEMBELAJARAN BERASASKAN MASALAH DALAM MENINGKATKAN PENGLIBATAN MURID SEMASA KELAS MATEMATIK DALAM TALIAN
Authors: Ali Salwani , Suppiah Shanmugam S. Kanageswari , Kamaludin Farah Aina
Published: January 2022

Cabaran melaksanakan pengajaran dan pembelajaran rumah (PdPR) semasa pandemik Covid-19 adalah murid kurang terlibat secara aktif semasa kelas. Kajian ini bertujuan mengkaji kemahiran fasilitasi guru menerusi penyoalan dan keberkesanan breakouts room dalam aplikasi Zoom dalam meningkatkan penglibatan murid. Kajian ini menggunakan kaedah pembelajaran berasaskan masalah (PBL) daripada Pendidikan Matematik Berasaskan Inkuiri (IBME). Kajian ini memfokuskan sejauh mana kemahiran fasilitasi guru menerusi penyoalan dan aplikasi breakouts room dapat meningkatkan penglibatan murid semasa kelas dalam talian. Topik Asas Nombor daripada silibus Matematik tingkatan empat dipilih untuk kajian ini. Kajian berasaskan kajian tindakan ini melibatkan 11 orang murid tingkatan empat di sebuah sekolah menengah di Perak dan 2 orang responden daripada kumpulan rakan kritikal. Borang penilaian video pengajaran, rakaman video pengajaran dan hasil kerja murid dianalisis secara kualitatif dan kuantitatif. Dapatan kajian menunjukkan bahawa kemahiran fasilitasi guru menerusi penyoalan KBAT yang baik dan aplikasi breakouts room dalam Zoom bagi kaedah PBL terbukti dapat meningkatkan penglibatan murid semasa kelas dalam talian.
A Corpus-Based Study on China English in the English Translation of Tao Te Ching
Authors: Jiao Jiaqi
Published: January 2022

This study aims to examine the features of China English in the translation of Chinese classics by comparing two versions of Tao Te Ching based on corpus data. Of the two English versions, one was translated by a well-known Chinese translator—Xu Yuanchong, and the other was translated by an American sinologist—Arthur Waley. This study found that Xu’s translation indicates more features of China English compared with Waley’s translation according to three major aspects. First, Xu’s translation is more concise, employing fewer words to translate Tao Te Ching. Second, Xu’s version features fewer clauses and more clear sentences. Third, the paratactic nature of China English is reflected in Xu’s translation, which has more content words and less cohesiveness. This study reveals the characteristics of China English in translation texts and partly fills the research gaps regarding the quantitative research in this field.
A Multimodal Discourse Analysis of “Lathi” Song
Authors: SINDA  , Ali Ahmad Jum’a Khatib Nur
Published: January 2022

Music has a personal interest in its individual. It can deliver happiness for those who listen to it. On the other hand, the music should correlate with its pictures through the video clip, such as color, sound, gesture, etc. This article attempts to investigate and explore the interpersonal meaning of the LATHI Song. This study was conducted qualitatively using a descriptive-analytical study to check how different semiotic and modes such as music, sound, speech, color, action, and facial expression work together to build the interpersonal meaning. LATHI song is successful in attracting audiences' attention around the world. The song's lyrics are mainly in English, except for the bridge sung in Javanese. Not only that, but the bridge also employs pelog, a Javanese seven-note scale used in gamelan arrangements. In addition, its instruments played has a unique characteristic and easy listening.
Analysis and Research on Spatial Nodes of Historical Villages based on Spatial Syntax Theory: Cuiwei Village in Qianshan Area of Zhuhai as an Example
Authors: Chen Yile , Chen Junzhang
Published: January 2022

This research takes Cuiwei Village located in Qianshan District of Zhuhai City as an example. The village is investigated and analyzed through field research, and the street scale, spatial structure, functional characteristics of streets, internal commercial distribution forms, and functions in the Cuiwei Historic Block are studied and analyzed. Based on the convex space analysis method and the line of sight analysis method in the space syntax theory, with the help of the Depthmap software, the complex street nodes, that is, the space of the two nodes A and B analyzed. Through the establishment of a viewshed model, including the analysis of the viewport integration degree, the viewport agglomeration degree, the viewport connection value and the spatial characteristics of the historical area, the most representative traditional buildings in the village, namely the Sanwang Temple and the Weishi Mansion, are selected. =N and when the radius R=3, observe the changes of the two parameters, the integration of the visual field and the visual depth of the two historical buildings. And with the help of Baidu time machine photos in different periods to observe and record the store's changes and people's behavioural characteristics. The results show that: at the present stage, the coordination of villages is poor, people's recognition in the village space is weak, and people cannot use local perception to reflect the overall space. There are obvious sub-interfaces between the interior of the village and the outside world—good but poor global intelligibility. After an on-the-spot investigation and analysis, it can be seen that although people can walk out of Cuiwei Village, they are always in a state of confusion, and it is difficult to grasp the spatial form of the overall area. Therefore, the space syntax analysis results are consistent with the field survey results, so this research method has good reference value and reference significance in the study of village space.
The Relationship of Child Labor and Globalization in the Philippines
Authors: Edora Cherry Anne , Esteban Narali , Sandoval Adeline
Published: January 2022

The problem of child labor has long been studied by economists, and most of it focuses on the microeconomic perspective. For this study, the researchers have decided to shift their focus to macroeconomic analysis. This study focuses on the effects of globalization and economic growth on the prevalence of child labor in the Philippines, mainly focusing on globalization, by using time-series analysis. Studies suggested that there is an inverted U-shaped relationship between globalization and child labor in developing countries, while other studies have determined a U-shaped relationship. The findings of this study reveal that there is no U-shape relationship between the variables but instead follows a linear relationship between globalization and child labor in the Philippine context. However, the lack of data and research publication on a national scale could influence the empirical results. Furthermore, this research can be used as literature in future studies.
The Influence of Smartphone Addiction, Personality Traits, Achievement Motivation on Problem-solving Ability of University Students
Authors: Ran Yaozong
Published: January 2022

This study aimed to analyze the relations between smartphone addiction, personality traits, achievement motivation and problem-solving ability and explore the influence of smartphone addiction, personality traits, achievement motivation on university students' problem-solving ability. 682 students (male = 227, female = 455) from a Chinese public university participated in the research voluntarily. Data were collected by the short-version of the smartphone addiction scale, the ten-item personality inventory, the achievement motives scale, and the social problem-solving inventory. The correlations and multiple hierarchical regression analysis were used to analyze the data. The results were as follows: Firstly, it was found that there was a significant negative correlation between smartphone addiction and achievement motivation and problem-solving ability, a significant positive correlation between achievement motivation and problem-solving ability, and a significant correlation between the factors of personality traits and smartphone addiction and problem-solving ability respectively. Secondly, it was found that emotional stability of personality traits, smartphone addiction and the "fear of failure" sub-dimensions of achievement motivation significantly explained problem-solving ability. Based on these research results, some suggestions were given for the improvement of the educational field.
Carcinoma de células pequeñas de cérvix, presentación de caso
Authors: García Hernández Mildrey , Carreño Rolando Ihosvannys Enrique , Curbelo Gutiérrez Luís Enrique
Published: January 2022

Introducción: El cáncer de cuello uterino es una de las principales causas de muerte por cáncer entre las mujeres. Los tumores neuroendocrinos son agresivos y se desarrollan a partir de células endocrinas en varios órganos, incluido el tracto genital femenino, y específicamente el cuello uterino. Objetivo: describir las características clínico- epidemiológicas del carcinoma de células pequeñas. Metodología: hicimos una revisión de la bibliografía sobre el tema y presentamos los resultados. Resultados: Representan entre el 0,9% y el 1,5% de todos los tumores del cuello uterino y generalmente afectan a las mujeres en edad reproductiva. Dada la rareza de la enfermedad, actualmente se dispone de datos limitados sobre la biología, el comportamiento clínico y el manejo de estos tumores agresivos. La asociación etiopatogénica entre el carcinoma de células pequeñas de cérvix (SCCC) y las infecciones por VPH de alto riesgo ha sido documentada en algunos estudios y tiene un pronóstico mucho peor en comparación con otros tipos histológicos de carcinoma cervical. Las modalidades de tratamiento del SCCC y del cáncer de pulmón de células pequeñas son similares debido a un comportamiento biológico similar. La quimioterapia es un componente importante de la terapia multimodal. Hicimos una presentación de caso de un paciente con diagnóstico de SCCC con una supervivencia global de seis años, muy por encima de la supervivencia internacional promedio. Conclusiones: deben continuar las investigaciones para llegar a un consenso sobre el tratamiento adecuado.
Carcinoma hepatoide del páncreas, presentación de caso
Authors: Amador García Yohan , Rangel Lorenzo Evelyn , Curbelo Gutiérrez Luís Enrique
Published: January 2022

Introducción: El carcinoma hepatoide del páncreas (CHP) es extremadamente raro. Es una neoplasia extrahepática primaria que se asemeja al carcinoma hepatocelular en términos de morfología e inmunohistoquímica. En el páncreas, el carcinoma hepatoide podría ser de forma pura o mezclarse con otros componentes histológicos como el tumor neuroendocrino o el adenocarcinoma ductal pancreático. Objetivo: describir las características clínico- epidemiológicas del carcinoma hepatoide del páncreas. Metodología: hicimos una revisión de la bibliografía sobre el tema y presentamos los resultados. Resultados: La inducción de hepatocitos en el páncreas se ha realizado en varios modelos animales. Se presenta un caso atendido en nuestra institución estadiado T3 N0 M1, Etapa clínica IV, que recibió tratamiento oncoespecífico con quimioterapia, esquema GEMOX (12 ciclos), con buena respuesta tumoral, que a los 6 meses se revalúa con TAC que evidencia ascitis de moderada cuantía, se decide tratamiento de segunda línea con esquema Gramont (6 ciclos) según respuesta.  Conclusiones: se trata de una entidad rara cuyo manejo se basa fundamentalmente en quimioterapia.
Tumor oncocítico hipersecretor de corteza suprarrenal, presentación de un caso
Authors: García Hernández Mildrey , Herrera Suárez Anairis , Curbelo Gutiérrez Luís Enrique
Published: January 2022

Introducción: El carcinoma adrenocortical es una entidad rara con una incidencia anual de 1- 2 casos por millón de personas. Las neoplasias oncocíticas que surgen en las glándulas suprarrenales son extremadamente raras, y por lo general se descubren como tumores no funcionales y en su mayoría benignos. Objetivo: describir las características clínico- epidemiológicas del tumor oncocítico hipersecretor de corteza suprarrenal. Metodología: hicimos una revisión de la bibliografía sobre el tema y presentamos los resultados. Resultados: Desde la primera descripción confirmada por microscopía electrónica en 1986, se han notificado aproximadamente 147 casos en la literatura, con mayor frecuencia descritos como hallazgos incidentales. Se presenta el caso de una mujer con tumor secretor de corteza suprarrenal tratado exitosamente, con desaparición de la clínica inicial y que se mantiene con excelente calidad de vida. Conclusiones: se trata de una entidad rara cuyo manejo se basa fundamentalmente en la cirugía.
Propuesta metodológica para la certificación energética de la arquitectura patrimonial de Cuenca (Ecuador) a partir del estudio de caso
Authors: Chérrez Sacoto Ana Carolina , Aguirre Ullauri María del Cisne
Published: January 2022

Introducción. En los últimos años se han posicionado múltiples sistemas de certificación ambiental en busca de combatir y reducir la contaminación que genera la industria de la construcción. Este es un tema clave para mejorar el consumo energético por lo que, a nivel mundial está consolidado nuevas edificaciones, y supone un desafío para su implementación en edificios patrimoniales de pequeña escala y usos cotidianos, como los existentes en el Centro Histórico de Cuenca (Ecuador). Objetivo. Generar una propuesta metodológica de certificación energética para inmuebles patrimoniales de valor ambiental, capaz de integrarse con los criterios de la rehabilitación establecidos para este tipo de edificaciones. Metodología. Se recurre a la revisión y evaluación de indicadores y criterios establecidos en las certificaciones LEED-H, BREEAM, VERDE y QH&E, juntamente con la caracterización del caso de estudio, y los factores del medio físico. Resultados. Se determina qué; una vivienda perteneciente a la categoría de valor patrimonial VA, respecto a la percepción de sus ocupantes posee un déficit en su iluminación, así como del confort por temperatura debido a la caracterización de los materiales que no aportan la transmitancia térmica suficiente para el paso adecuado del calor en la vivienda, lo que se refleja en el consumo final de energía de 425.97 kWh/mes/unidad de vivienda. Finalmente, el esquema de propuesta metodológica permite compatibilizar la certificación energética con la rehabilitación patrimonial. Conclusión. El análisis concluye que en la edificación el consumo de energía es elevado debido al uso actual que se le da, además, la amplia diversidad edificatoria exige un esquema metodológico flexible que permita estudiar según los parámetros propios, cada edificación y orientar su certificación.
Modelo para la determinación del ratio de secado del matico y ortiga en la región sierra ecuatoriana
Authors: Guerrero Luzuriaga Sebastian Alberto , Herrera Chávez Byron Adrián , Zurita Gallegos Ronald Mauricio , Palacios Sotomayor Dayana Maité
Published: January 2022

Se precisa transferir ciencia y la tecnología en la mejora de las producciones agrícolas, a los productores de la región andina ecuatoriana,, y mejorar la comercialización de sus producciones. El objetivo de esta investigación es proveer modelo para la mejora de los productos del matico y ortiga en su procesamiento. Se realizaron secados experimentales de las plantas en un secador eléctrico tipo túnel de bandejas a temperaturas de 45 C, 55 C y 65 C con una duración de 6 horas para la temperatura de 45 C, 5 horas para 55 C y 4 horas para 65 C, cada experimento con 4 repeticiones. Se adoptan estudios exploratorios, descriptivos, explicativos. Se apelan a métodos estadísticos-matemáticos, inductivos-deductivos, de expertos, análisis y síntesis de fuentes. Los resultados en la determinación de la ratio de secado de matico y ortiga se utilizó el modelo matemático de la curva característica basado en la ecuación y = Ax + B; obteniendo valores para la ortiga de A=-0,0006x2-0,0704x+1.9485 y B=-0,007x-0,0136; para el caso del matico A=-0,0007x2-0,0793x+2,25 y B=-0,007x-0,0184 en todas las ecuaciones, x, representa la temperatura de secado. Estas ecuaciones, obtuvieron valores de los cuales se formuló la ratio de secado con ecuación RS=ln (mr)-A/B, que se determina en un contenido de humedad del 12% al 14%. Estos demuestran la viabilidad del modelo y su aplicación inmediata. Se concluye en socializar a productores de la provincia y la región sierra ecuatoriana este modelo de secado.
Formación tecnológica de la competencia de traducción y el uso de ejercicios comunicativos para desarrollar destrezas de lectura en textos de diferente género en inglés
Authors: Herrera Andrade Zoila Victoria , Rodríguez Arella Nancy Georgina , Guijarro Paguay Sandra Leticia
Published: January 2022

El artículo está dedicado a la tecnología del uso de ejercicios comunicativos en la enseñanza de la lectura, que ayudan a enseñar a los estudiantes cómo trabajar con textos de diferentes géneros y desarrollar y mejorar esta habilidad. La referencia repetida al texto de acuerdo con esta tecnología desarrolla no solo la capacidad de leer, sino que también le permite alcanzar su comprensión a nivel de significado. Este artículo corresponde a una propuesta considerando una serie de ejercicios comunicativos diseñados para trabajar con textos de diferente tipo y contribuir no solo a la comprensión de lo leído, sino también a la expresión del habla de alta calidad con la expresión de la propia opinión. La experiencia de organizar el trabajo independiente en inglés como lengua extranjera en el nivel 0 - B1, a través las tecnologías informáticas utilizando para ello: parte de las ayudas didácticas electrónicas disponibles en la red de datos. El cambio en el número de horas de carga académica disponible para el aula de clases requiere la actualización y creación de materiales didácticos electrónicos. Por otra parte, la competencia comunicativa de los universitarios en el estudio de una lengua extranjera, empleando métodos innovadores para pronunciar correctamente la lengua inglesa, en esta etapa importante de aprendizaje para la generación de enunciados en forma dialógica como monológica, mediante ejemplos con los que se puede construir una guía didáctica para el manejo de cada tema contemplado en el currículo de inglés.
Indicadores de Balance Social en el sector cooperativista
Authors: Sánchez Lunavictoria Jacqueline Carolina , Cuadrado Sánchez Gina Patricia , Cárdenas Muñoz Jorge Vinicio
Published: January 2022

Introducción. Las cooperativas de ahorro y crédito constituyen un componente fundamental en la sociedad ya que contribuyen de manera significativa a la construcción de una economía participativa, democrática y solidaria. No obstante, el compromiso de asumir la responsabilidad producto de su accionar es deber de toda organización, superando el enfoque filantrópico y altruista con el que muchas veces se confunde este término. Es así como el objetivo que se plantea esta investigación es aplicar indicadores que permitan evaluar la gestión de responsabilidad social, alineados al cumplimiento de los principios cooperativos. Metodología. La investigación es de tipo no experimental de corte transversal descriptiva, una vez que los hallazgos han sido presentados estos se describen y se sintetizan en base a una interpretación. Resultados. La aplicación de 23 indicadores de balance social, articulados a los principios cooperativos permitieron evaluar la gestión de responsabilidad social de la organización y proporcionar información que sirva de base para la toma de decisiones. Conclusiones. A partir de los resultados obtenidos se puede concluir que en la organización existen muy pocas deficiencias a nivel de la gestión social que deben ser atendidas ya que en gran parte los resultados registran resultados satisfactorios.
VAKIF YÜKSEKÖĞRETİM KURUMLARI İLE AKADEMİK PERSONEL ARASINDA BELİRLİ SÜRELİ İŞ SÖZLEŞMESİ YAPILIP YAPILAMAYACAĞI SORUNU
Authors: GÖKTAŞ Seracettin
Published: January 2022

2547 sayılı Yükseköğretim Kanunu’nun ek 2’nci maddesine göre vakıf yükseköğretim kurumları öğretim elemanlarını bu Kanun’daki usul ve esaslara göre temin edebilirler. Yükseköğretim Kanunu’nun ek 5’inci maddesine göre, vakıf yükseköğretim kurumları ile öğretim elemanları arasındaki ilişki, sözleşmeye dayanmaktadır. Vakıf yükseköğretim kurumları ile öğretim elemanları arasında kurulan sözleşmenin iş sözleşmesi olarak nitelendirilmesi halinde bunlarla belirli süreli iş sözleşmesi yapılıp yapılamayacağı hukuki sorunu ortaya çıkmaktadır. 4857 sayılı İş Kanunu’nun 11’inci maddesi, işverenin belirli süreli iş sözleşmesi yapma özgürlüğünü sınırlandırmıştır. Buna göre, ancak objektif şartların bulunması halinde belirli süreli iş sözleşmesi yapılabilir. Öğreti ve uygulamaya göre sözleşmenin belirli süreli yapılması gerektiğine ilişkin kanuni bir düzenleme bulunması halinde objektif şartların varlığı aranmaz. Yükseköğretim Kanunu’nda doktor öğretim üyeleri, öğretim üyesi pozisyonunda işe alınan öğretim görevlileri ve araştırma görevlilerinin süreli olarak atanabilecekleri düzenlenmiş bulunduğundan, bunlarla yapılan sözleşmenin belirli süreli olması gerekir. Buna karşılık, eğitim-öğretim faaliyeti süreklilik arz ettiğinden, objektif şartlar bulunmadıkça, doçentlik ve profesörlük pozisyonunda görev yapan öğretim üyeleri ile belirli süreli iş sözleşmesi yapılamaz.
Intrahepatic cholangiocarcinoma: Tumour heterogeneity and its clinical relevance
Authors: Komuta Mina
Published: January 2022

Treatment of intrahepatic cholangiocarcinoma (iCCA) is currently at a significant turning point due to the identification of isocitrate dehydrogenase (IDH) mutations and fibroblast growth factor receptor (FGFR) fusions that can be targeted with currently available therapies. Clinical trials of these targeted therapies have been promising, and the iCCA patients who may benefit from these targeted treatments can be identified by pathological examination prior to molecular investigations. This is because IDH mutations and FGFR fusions are mainly seen in the small duct type iCCA, a subtype of iCCA defined by the 5th World Health Organization classification, which can be recognized by the pathological diagnostic process. Therefore, pathology plays an important role in precision medicine for iCCA, not only in confirming the diagnosis, but also in identifying the iCCA patients who may benefit from targeted treatments. However, caution is advised with the pathological diagnosis, as iCCA shows tumour heterogeneity, making it difficult to distinguish small duct type iCCA from hepatocellular carcinoma (HCC), and combined HCC-CCA. This review focuses on the pathological/molecular features of both subtypes of iCCA (large and small duct types), as well as their diagnostic pitfalls, clinical relevance, and future perspectives.
Evaluation of the Quality of Medical Care to the Population at the Level of Day Stations and Emergency Stations
Authors: Niyazov B. , Niyazovа S.
Published: January 2022

Insufficient availability of emergency medical services to the rural population is noted. The dynamics of the growth of calls to emergency medical services testifies to the fact that emergency medical institutions have taken over part of inpatient services for the provision of emergency care to patients with chronic diseases and acute colds.
Process Models of Development of a Triad of Subsystems of Medical and Preventive Institutions: Management, Resources, Potential. Control
Authors: Niyazov B. , Niyazovа S.
Published: January 2022

Frontal analysis of the activities of medical and preventive institutions on the basis of the process model involves an objective assessment of the activities of all sections of preventive and therapeutic and diagnostic work, identification of shortcomings and reserves, foresight on this basis of the results of the work of medical and preventive institutions.
PR as a Tool of Political Technologies (on the Example of the 2020 Parliamentary Elections in Kyrgyzstan)
Authors: Bokoeva Zh. , Akmatbekova Zh. , Sydygalieva D.
Published: January 2022

The main task of elections in a democratic state is not only to elect representatives of power, but also to ensure the legitimacy of newly elected persons and the political system as a whole. Today, elections are one of the most democratic ways for voters to freely express their opinion in matters of appointing the heads of legislative and executive bodies of power. Consequently, the most important and indispensable condition for a democratic system is free elections. Elections are designed to perform functions such as electing a new political elite, resolving conflicts, reflecting the interests and opinions of various peoples, social strata and groups of society, mobilizing the population to support party programs and social values, etc. PR-technologies occupy a special place in election campaigns. In this regard, the article examines PR-technologies used by parties in the 2020 parliamentary elections in Kyrgyzstan. The study covers the time period from September 4 to October 3, 2020. As part of the study, a linguistic analysis of information posted on the official websites and social pages of parties, media reports and reports of relevant organizations was carried out. Based on the results of the study, a number of practical recommendations have been developed that must be taken into account during the next parliamentary and presidential elections.
Essence of Upbringing Process and the Competence Approach in Training
Authors: Batyraliev A. , Tashmatova D. , Abdullaeva Zh.
Published: January 2022

Research relevance: understanding of teaching concept related to main function of а teacher in teaching and educating students. In the learning process, teacher should pay special attention to students’ cognitive activity development and try to use it more in learning process, using innovative technologies and interactive methods. Research objectives: consider issues from the concept of teaching, “learning” and “competence” and their essence, to reveal the importance of the competence-based approach in teaching. Research materials and methods: article analyzes essence of learning process and authors give their point of view. Research results: educational process essence and importance of learning based on modern competencies revealed. Conclusions: learning competence includes set of a student’s educational achievements, expressed by level of basic and subject competence at a certain stage in educational process.
Corpus-based Data-driven Learning to Develop Senior Students’ Research Writing Skills: Practical Insights
Authors: Nurmatova G.
Published: January 2022

The article introduces corpus-based DDL (Data-driven Learning) technologies in teaching ESP (English for Specific Purposes). The aim of the author is twofold: to offer English language teachers to design grammatical and lexical activities to develop senior students’ research writing skill and to assist senior students to construct scholarly field-related sentences. For the purpose of the study, the author used a mini manually compiled corpus of robotics, one of the branches of mechanical engineering and demonstrated practical instructions of corpus-based grammatical and lexical insights with DDL technologies. In spite of some limitations and future research, the findings of the study can contribute language teachers to develop senior students’ productive (writing) skills via designing corpus-based data driven materials as well as improve students to construct grammatically and lexically correct sentences for succeeding in their further research and career growth.
Increase of Student’s Educational and Recognitive Self-activity in Kyrgyz National Sports Wrestling Kuresh
Authors: Anarkulov R. , Bekboev Zh.
Published: January 2022

Research relevance: article deals with the problem of increasing the effectiveness of educational and cognitive independence of those who go in for the Kyrgyz national wrestling kuresh. Research objectives: setting educational, upbringing and health-improving tasks that contributes to the increase of educational and cognitive independence (OPS) of those who go in for kuresh wrestling. Research materials and methods: the work describes teaching method, the originality of the theoretical and practical approach to the transfer of special information through the implementation of: observation, discussion and partial search. Research results: the type of occupation of young kuresh wrestlers predetermines the ratio of ways and techniques, their mutual significance, use of unusual approaches in the upbringing of those who go in for kuresh wrestling. Conclusions: in kuresh wrestling, the system of questions should correspond to the traditionally established stages of the studied aspects of educational and cognitive material and technical and tactical action.
Problems in the Social Life of the Resettled Population in Uzbekistan (1925-1941)
Authors: Xolmuminov X. , Eshmuminov O.
Published: January 2022

This article highlights the policy of resettlement of households and problems in the social life of the population in Uzbekistan and its southern regions. Along with this, from a scientific point of view, the state of the farms of the resettled population and the problems of providing them with housing, medical care and in the field of education are analyzed.