bluuebunny/crossref_metadata_2025 huggingface dataset:
The left ventricular outflow tract and carotid artery velocity time integrals
Authors: Kenny Jon-Emile S.
Published: January 2024

The left ventricular outflow tract velocity time integral (LVOT VTI) is commonly used in the intensive care unit as a measure of stroke volume (SV) and how the SV changes in response to an intervention; therefore, the LVOT VTI is used to guide intravenous fluid management. Various peripheral Doppler surrogates are proposed to infer the LVOT VTI (e.g., measures from the common carotid artery). A recently-described, novel method of insonation has an excellent ability to detect change in the LVOT VTI. This approach raises important facets of Doppler flow and insonation error, as well as the general principles at play when using a peripheral artery to infer changes from the left ventricle. Relating the VTI of a peripheral artery to the LVOT VTI was recently described mathematically and may help clinicians think about the Doppler relationship between central and peripheral flow.
Neurophysiology of male sexual arousal—Behavioral perspective
Authors: Bogacki-Rychlik Wiktor , Gawęda Katarzyna , Bialy Michal
Published: January 2024

In the presented review, we analyzed the physiology of male sexual arousal and its relation to the motivational aspects of this behavior. We highlighted the distinction between these processes based on observable physiological and behavioral parameters. Thus, we proposed the experimentally applicable differentiation between sexual arousal (SA) and sexual motivation (SM). We propose to define sexual arousal as an overall autonomic nervous system response leading to penile erection, triggered selectively by specific sexual cues. These autonomic processes include both spinal and supraspinal neuronal networks, activated by sensory pathways including information from sexual partner and sexual context, as well as external and internal genital organs. To avoid misinterpretation of experimental data, we also propose to precise the term “sexual motivation” as all actions performed by the individual that increase the probability of sexual interactions or increase the probability of exposition to sexual context cues. Neuronal structures such as the amygdala, bed nucleus of stria terminalis, hypothalamus, nucleus raphe, periaqueductal gray, and nucleus paragigantocellularis play crucial roles in controlling the level of arousal and regulating peripheral responses via specific autonomic effectors. On the highest level of CNS, the activity of cortical structures involved in the regulation of the autonomic nervous system, such as the insula and anterior cingulate cortex, can visualize an elevated level of SA in both animal and human brains. From a preclinical perspective, we underlie the usefulness of the non-contact erection test (NCE) procedure in understanding factors influencing sexual arousal, including studies of sexual preference in animal models. Taken together results obtained by different methods, we wanted to focus attention on neurophysiological aspects that are distinctly related to sexual arousal and can be used as an objective parameter, leading to higher translational transparency between basic, preclinical, and clinical studies.
Glaucoma: from pathogenic mechanisms to retinal glial cell response to damage
Authors: Fernández-Albarral Jose A. , Ramírez Ana I. , de Hoz Rosa , Matamoros José A. , Salobrar-García Elena , Elvira-Hurtado Lorena , López-Cuenca Inés , Sánchez-Puebla Lidia , Salazar Juan J. , Ramírez José M.
Published: January 2024

Glaucoma is a neurodegenerative disease of the retina characterized by the irreversible loss of retinal ganglion cells (RGCs) leading to visual loss. Degeneration of RGCs and loss of their axons, as well as damage and remodeling of the lamina cribrosa are the main events in the pathogenesis of glaucoma. Different molecular pathways are involved in RGC death, which are triggered and exacerbated as a consequence of a number of risk factors such as elevated intraocular pressure (IOP), age, ocular biomechanics, or low ocular perfusion pressure. Increased IOP is one of the most important risk factors associated with this pathology and the only one for which treatment is currently available, nevertheless, on many cases the progression of the disease continues, despite IOP control. Thus, the IOP elevation is not the only trigger of glaucomatous damage, showing the evidence that other factors can induce RGCs death in this pathology, would be involved in the advance of glaucomatous neurodegeneration. The underlying mechanisms driving the neurodegenerative process in glaucoma include ischemia/hypoxia, mitochondrial dysfunction, oxidative stress and neuroinflammation. In glaucoma, like as other neurodegenerative disorders, the immune system is involved and immunoregulation is conducted mainly by glial cells, microglia, astrocytes, and Müller cells. The increase in IOP produces the activation of glial cells in the retinal tissue. Chronic activation of glial cells in glaucoma may provoke a proinflammatory state at the retinal level inducing blood retinal barrier disruption and RGCs death. The modulation of the immune response in glaucoma as well as the activation of glial cells constitute an interesting new approach in the treatment of glaucoma.
On the interplay between speech perception and production: insights from research and theories
Authors: Arjmandi Meisam K. , Behroozmand Roozbeh
Published: January 2024

The study of spoken communication has long been entrenched in a debate surrounding the interdependence of speech production and perception. This mini review summarizes findings from prior studies to elucidate the reciprocal relationships between speech production and perception. We also discuss key theoretical perspectives relevant to speech perception-production loop, including hyper-articulation and hypo-articulation (H&H) theory, speech motor theory, direct realism theory, articulatory phonology, the Directions into Velocities of Articulators (DIVA) and Gradient Order DIVA (GODIVA) models, and predictive coding. Building on prior findings, we propose a revised auditory-motor integration model of speech and provide insights for future research in speech perception and production, focusing on the effects of impaired peripheral auditory systems.
Lacking P2X7-receptors protects substantia nigra dopaminergic neurons and hippocampal-related cognitive performance from the deleterious effects of high-fat diet exposure in adult male mice
Authors: Rossi Chiara , Distaso Mariarosaria , Raggi Francesco , Kusmic Claudia , Faita Francesco , Solini Anna
Published: January 2024

Background

Dietary fat consumption, involved in the pathogenesis of insulin resistance and impaired glucose metabolism, is linked with decline in cognitive functions, dementia, and development of Parkinson’s disease and Alzheimer’s disease. Mature IL-1β, requiring the activation of the P2X7 receptor (P2X7R)-inflammasome complex, is an important mediator of neuroinflammation. The aim of the study was to test whether P2X7R activation might interfere with systemic and cerebral metabolic homeostasis.

Methods

We treated WT and P2X7R KO mice with a high-fat diet (HFD) for 16 weeks, evaluating the effects on the Substantia Nigra and Hippocampus, target areas of damage in several forms of cognitive impairment.

Results

HFD-treated WT and P2X7R KO mice showed a different brain mRNA profile of Insulin and Igf-1, with these genes and relative receptors, more expressed in KO mice. Unlike P2X7R KO mice, WT mice treated with HFD displayed a diameter reduction in dopaminergic neurons in the Substantia Nigra, accompanied by an increased IBA1 expression in this area; they also showed poor performances during Y-Maze and Morris Water Maze, tasks involving Hippocampus activity. Conversely, Parkin, whose reduction might promote neuronal cell death, was increased in the brain of P2X7R KO animals.

Conclusion

We report for the first time that HFD induces damage in dopaminergic neurons of the Substantia Nigra and a Hippocampus-related worse cognitive performance, both attenuated in the absence of P2X7R. The involved mechanisms might differ in the two brain areas, with a predominant role of inflammation in the Substantia Nigra and a metabolic derangement in the Hippocampus.
Effectiveness of omega-3 fatty acid supplementation for pruritus in patients undergoing hemodialysis
Authors: Rafieipoor Alireza , Torkaman Mahdie , Azaryan Fatemeh , Tavakoli Aryan , Mohammadian Mohammad Keshavarz , Kohansal Atefeh , Shafaei Hanieh , Mirzaee Pouya , Motiee Bijarpasi Zeinab , Bahmani Parsa , Khosravi Masoud , Doaei Saeid , Gholamalizadeh Maryam
Published: January 2024

Background

Patients undergoing hemodialysis (HD) frequently experience the chronic kidney disease-associated pruritus (CKD-aP).

Objective

The aim of this study was to investigate the effectiveness of omega-3 supplementation in the management of CKD-aP in patients undergoing hemodialysis.

Methods

In this triple blind, randomized clinical trial, the effect of the omega-3 supplement on uremic CKD-aP was assessed in 112 chronic hemodialysis patients at Caspian Hemodialysis Center in Rasht, Iran. Patients were randomly divided into the intervention group receiving omega-3 supplements (3 g/day) and the control group receiving placebo containing MCT oil for 2 months.

Results

Omega-3 supplementation had no effect on CKD-aP. The results did not change after adjusting for age and sex, additional adjustments for weight, height, physical activity, smoking, and alcohol use, additional adjustments for underlying diseases and weight, height, physical activity, smoking, and drinking alcohol, and further adjustments for underlying diseases and biochemical indices.

Discussion

Omega-3 supplementation for 2 months had no effect on CKD-aP in patients with CKD. Further studies with longer duration are warranted.

Clinical Trial Registration

https://www.irct.ir/trial/66638, IRCT20151226025699N6
Characteristics of patients with newly diagnosed hematological malignancies referred for echocardiography
Authors: Kępski Jarosław , Szmit Sebastian , Lech-Marańda Ewa
Published: January 2024

Objective

The importance of cardio-hemato-oncology programs is increasing. The main aim of the study was to identify all coexisting cardiovascular disorders in patients with new hematological malignancies referred for echocardiography during baseline evaluation before anticancer therapy.

Material and methods

The study was based on 900 echocardiographic examinations performed within 12 months at the Institute of Hematology and Transfusion Medicine in Poland: 669 tests (74.3%) were dedicated to hemato-oncology patients at the different stages of cancer therapy, however almost a third of the tests (277, 30.8%) were part of a baseline evaluation before starting first line anticancer therapy due to newly diagnosed hematological malignancies.

Results

The group of 277 patients with new hematological malignancies (138 women, 49.82%) with a median age of 66 years (interquartile range: 53-72 years) was included in the main analyses. The three most frequent new histopathological diagnoses were: non-Hodgkin lymphoma (63 cases; 22.74%), acute myeloid leukaemia (47 cases; 16.97%), and multiple myeloma (45 cases; 16.25%). The three most common clinical cardiology disorders were arterial hypertension (in 133 patients, 48.01%), arrhythmias (48 patients, 17.33%), and heart failure (39 patients, 14.08%). Among 48 patients with arrhythmias there were 22 cases with atrial fibrillation. The most frequently detected echocardiographic abnormality was Left Atrial Volume Index >34 ml/m2 which was present in 108 of 277 patients (38.99%) and associated with a significantly greater chance of concomitant diagnosis of arrhythmias (OR=1.98; p=0.048) especially atrial fibrillation (OR=3.39; p=0.025). The second most common echocardiographic finding was diastolic dysfunction 2nd or 3rd degree revealed in 43 patients (15.52%) and associated with a greater chance of simultaneous diagnosis of heart failure (OR=8.32; p<0.0001) or arrhythmias (OR=4.44; p<0.0001) including atrial fibrillation (OR=5.40; p=0.0003).

Conclusions

In patients with newly diagnosed hematological malignancies left ventricular diastolic dysfunction is a common abnormality in echocardiography and may determine diagnoses of heart failure or arrhythmias.
Prediction of cervical lymph node metastasis in solitary papillary thyroid carcinoma based on ultrasound radiomics analysis
Authors: Li Mei hua , Liu Long , Feng Lian , Zheng Li jun , Xu Qin mei , Zhang Yin juan , Zhang Fu rong , Feng Lin na
Published: January 2024

Objective

To assess the utility of predictive models using ultrasound radiomic features to predict cervical lymph node metastasis (CLNM) in solitary papillary thyroid carcinoma (PTC) patients.

Methods

A total of 570 PTC patients were included (456 patients in the training set and 114 in the testing set). Pyradiomics was employed to extract radiomic features from preoperative ultrasound images. After dimensionality reduction and meticulous selection, we developed radiomics models using various machine learning algorithms. Univariate and multivariate logistic regressions were conducted to identify independent risk factors for CLNM. We established clinical models using these risk factors. Finally, we integrated radiomic and clinical models to create a combined nomogram. We plotted ROC curves to assess diagnostic performance and used calibration curves to evaluate alignment between predicted and observed probabilities.

Results

A total of 1561 radiomics features were extracted from preoperative ultrasound images. After dimensionality reduction and feature selection, 16 radiomics features were identified. Among radiomics models, the logistic regression (LR) model exhibited higher predictive efficiency. Univariate and multivariate logistic regression results revealed that patient age, tumor size, gender, suspicious cervical lymph node metastasis, and capsule contact were independent predictors of CLNM (all P < 0.05). By constructing a clinical model, the LR model demonstrated favorable diagnostic performance. The combined model showed superior diagnostic efficacy, with an AUC of 0.758 (95% CI: 0.712-0.803) in the training set and 0.759 (95% CI: 0.669-0.849) in the testing set. In the training dataset, the AUC value of the nomogram was higher than that of the clinical and radiomics models (P = 0.027 and 0.002, respectively). In the testing dataset, the AUC value of the nomogram model was also greater than that of the radiomics models (P = 0.012). However, there was no significant statistical difference between the nomogram and the clinical model (P = 0.928). The calibration curve indicated a good fit of the combined model.

Conclusion

Ultrasound radiomics technology offers a quantitative and objective method for predicting CLNM in PTC patients. Nonetheless, the clinical indicators persists as irreplaceable.
Feasibility of wearable activity tracking devices to measure physical activity and sleep change among adolescents with chronic pain—a pilot nonrandomized treatment study
Authors: Junghans-Rutelonis Ashley , Sim Leslie , Harbeck-Weber Cynthia , Dresher Emily , Timm Wendy , Weiss Karen E.
Published: January 2024

Purpose

Personal informatics devices are being used to measure engagement in health behaviors in adults with chronic pain and may be appropriate for adolescent use. The aim of this study was to evaluate the utilization of a wearable activity tracking device to measure physical activity and sleep among adolescents attending a three-week, intensive interdisciplinary pain treatment (IIPT) program. We also assessed changes in physical activity and sleep from baseline to the treatment phase.

Methods

Participants (57.1% female, average age 15.88, SD = 1.27) wore an activity tracking device three weeks prior to starting and during the treatment program.

Results

Of 129 participants contacted, 47 (36.4%) agreed to participate. However, only 30 (64%) complied with the instructions for using the device prior to programming and during program participation. Preliminary analyses comparing averages from 3-weeks pre-treatment to 3-weeks during treatment indicated increases in daily overall activity minutes, daily step counts, and minutes of moderate to vigorous physical activity (by 353%), as well as a corresponding decrease in sedentary minutes. There was more missing data for sleep than anticipated.

Conclusions

Wearable activity tracking devices can be successfully used to measure adolescent physical activity in-person, with more difficulty obtaining this information remotely. Adolescents with chronic pain experience improvements in objective measurements of physical activity over the course of a 3-week IIPT program. Future studies may want to spend more time working with pediatric patients on their understanding of how to use trackers for sleep and physical activity.
Assessing NH300094, a novel dopamine and serotonin receptor modulator with cognitive enhancement property for treating schizophrenia
Authors: Feng Zijin , Hu Zhijing , Li Lei , Yu Minquan , Zhang Yiting , Jing Peng , Xu Xiangqing , Wu Jinhui , Hu Yiqiao , Xu Xiangyang
Published: January 2024

Background: Schizophrenia is a serious psychiatric disorder that significantly affects the quality of life of patients. The objective of this study is to discover a novel antipsychotic candidate with highly antagonistic activity against both serotonin and dopamine receptors, demonstrating robust efficacy in animal models of positive, negative, and cognitive symptoms of schizophrenia.

Methods: In the present study, we examined the activity of antipsychotic drug (NH300094) on 5-HT2A, 5-HT2C, 5-HT1A, 5-HT1B, 5-HT7, H1, M1, Alpha1A, D2L, D2S, Alpha2A, D3 receptor functional assay in vitro. In addition, multiple animal models, including dizocilpine (MK-801) induced hyper-locomotion; APO induced climbing; Conditioned Avoidance Response (CAR); DOI-Induced Head Twitch; Forced swimming test; Scopolamine induced cognitive impairment model, were used to verify the antipsychotic activity of NH300094 in preclinical.

Results:In vitro functional assays have indicated that NH300094 is a potent antagonist of 5-HT receptors and dopamine receptors, with higher relative antagonistic activity against 5-HT2A receptor (5-HT2A IC50 = 0.47 nM) than dopamine receptors (D2L IC50 = 1.04 nM; D2S IC50 = 11.71 nM; D3 IC50 = 31.55 nM). Preclinical in vivo pharmacological study results showed that NH300094 was effective in multiple models, which is more extensive than the clinic drug Risperidone. Furthermore, the safety window for extrapyramidal side effects of NH300094 is significantly wider than that of Risperidone (For NH300094, mice catalepsy model ED50/ Mice MK-801 model ED50 = 104.6-fold; for Risperidone, mice catalepsy model ED50/ Mice MK-801 model ED50 = 12.9-fold), which suggests a potentially better clinical safety profile for NH300094.

Conclusion: NH300094 is a novel potent serotonin and dopamine receptors modulator, which has good safety profile and therapeutic potential for the treatment of schizophrenia with cognition disorders.
Effects of unburned tobacco smoke on inflammatory and oxidative mediators in the rat prefrontal cortex
Authors: Vivarelli Fabio , Morosini Camilla , Rullo Laura , Losapio Loredana Maria , Lacorte Antonio , Sangiorgi Stefano , Ghini Severino , Fagiolino Ivan , Franchi Paola , Lucarini Marco , Candeletti Sanzio , Canistro Donatella , Romualdi Patrizia , Paolini Moreno
Published: January 2024

Although the Food and Drug Administration has authorized the marketing of “heat-not-burn” (HnB) electronic cigarettes as a modified risk tobacco product (MRTP), toxicological effects of HnB smoke exposure on the brain are still unexplored. Here, paramagnetic resonance of the prefrontal cortex (PFC) of HnB-exposed rats shows a dramatic increase in reactive radical species (RRS) yield coupled with an inflammatory response mediated by NF-κB-target genes including TNF-α, IL-1β, and IL-6 and the downregulation of peroxisome proliferator-activated receptor (PPAR) alpha and gamma expression. The PFC shows higher levels of 8-hydroxyguanosine, a marker of DNA oxidative damage, along with the activation of antioxidant machinery and DNA repair systems, including xeroderma pigmentosum group C (XPC) protein complex and 8-oxoguanine DNA glycosylase 1. HnB also induces the expression of drug-metabolizing enzymes such as CYP1A1, CYP2A6, CYP2B6, and CYP2E, particularly involved in the biotransformation of nicotine and several carcinogenic agents such as aldehydes and polycyclic aromatic hydrocarbons here recorded in the HnB stick smoke. Taken together, these effects, from disruption of redox homeostasis, inflammation, PPAR manipulation along with enhanced bioactivation of neurotoxicants, and upregulation of cMYC protooncogene to impairment of primary cellular defense mechanisms, suggest a possible increased risk of brain cancer. Although the HnB device reduces the emission of tobacco toxicants, our findings indicate that its consumption may carry a risk of potential adverse health effects, especially in non-smokers so far. Further studies are needed to fully understand the long-term effects of these devices.
Application of a digital twin for highway tunnels based on multi-sensor and information fusion
Authors: Yang Xun , Yu Shanchuan , Wang Jun , Chen Hong , Huang Yonggang , Luo Zhongbin , Fu Lijia
Published: January 2024

Due to the harsh environment of highway tunnels and frequent breakdowns of various detection sensors and surveillance devices, the operational management of highway tunnels lacks effective data support. This paper analyzes the characteristics of operational surveillance data in highway tunnels. It proposes a multimodal information fusion method based on CNN–LSTM–attention and designs and develops a digital twin for highway tunnel operations. The system addresses issues such as insufficient development and coordination of the technical architecture of operation control systems, weak information service capabilities, and insufficient data application capabilities. The system also lacks intelligent decision-making and control capabilities. The developed system achieves closed-loop management of “accurate perception–risk assessment–decision warning–emergency management” for highway tunnel operations based on data-driven approaches. The engineering demonstration application underscores the system’s capacity to enhance tunnel traffic safety, diminish tunnel management costs, and elevate tunnel driving comfort.
Calculation of a conversion factor for estimating the glycolytic contribution in exercise from post-exercise blood lactate concentration
Authors: Hill David W. , Mihalek John Michael
Published: January 2024

Purpose: Often, the glycolytic contribution in a bout of heavy or severe intensity exercise is estimated by multiplying the increase in blood lactate concentration above resting levels that is engendered by the exercise (in mM) by 3.3 (or 3) mL·kg−1 per mM. Our purpose was to verify the value of this conversion factor, using methods that were completely different from those of the original studies.

Methods: Six women (mean ± SD), age, 23 ± 1 year; VO2max, 46 ± 4 mL·kg−1·min−1) and three men (23 ± 0 years; 54 ± 8 mL·kg−1·min−1) completed 6 min of heavy intensity exercise in conditions of normoxia and hypoxia (FIO2, ∼12%). VO2 was measured throughout the exercise and 7 min of recovery. The increase in glycolytic contribution was estimated as the reduction in aerobic contribution in hypoxia, after correction for the effects of hypoxia on the oxygen demand and on the contribution from phosphocreatine. The peak post-exercise blood lactate concentration was measured in fingerstick blood samples.

Results: The ratio between the increase in estimated glycolytic contribution (in mL·kg–1) in hypoxia and the increase in peak blood lactate concentration (in mM) yielded an oxygen equivalent of 3.4 ± 0.4 mL·kg–1 per mM (range, 2.6 mL·kg−1 per mM to 4.0 mL·kg−1 per mM) for cycle ergometer exercise.

Conclusion: These results generally support the use of a common conversion factor to calculate the glycolytic contribution from post-exercise blood lactate concentrations. However, there is some inter-individual variability in the conversion factor.
Does elite European match-play affect salivary immunoglobulin-A and cortisol in soccer players? The influence of playing status and match outcome
Authors: Morgans R. , Oliveira R. , Rhodes D. , Orme P. , Ceylan H. I. , González-Fernández F. T. , Linán-González A. , Moreira A.
Published: January 2024

Introduction: The aims of this study were to: a) investigate salivary immunoglobulin A (s-IgA) and cortisol (s-Cort) responses to nine competitive fixtures in starting and non- starting soccer players; and b) compare s-IgA and s-Cort responses of starters and non-starters considering match outcome.

Methods: Saliva from 19 male outfield players from an elite soccer team (mean ± SD, age 26 ± 4 years; weight 80.5 ± 8.1 kg; height 1.83 ± 0.07 m; body-fat 10.8% ± 0.7%) was collected. Saliva samples were taken on the day before each match (MD-1), 60-min before kick-off (MDpre), 30-min post-match (MDpost), and 72-h post-match (MD+3). There were five wins, one draw and three losses.

Results: The mean s-IgA value was found to be significantly lower at MD+3 compared to MDpre and MDpost. s-Cort was significantly higher at MDpost compared to MD-1 and MDpre. When compared to MDpre, a statistically significant decrease in s-Cort was observed at MD+3 compared to MDpost. Starters displayed higher s-Cort values across the nine matches. There was a significant group-by-time interaction for s-Cort. There was a significant increase in s-Cort levels at MDpost compared to MD-1 and from MDpre to MDpost in starting players. At MDpost, starters had significantly higher s-Cort values. s-IgA values of starting and non- starting players following successful and unsuccessful matches did not reveal a significant difference. However, similar analysis of s-Cort in successful matches showed a significant difference between starters and non-starters. s-IgA values at MD-1, MDpre, MDpost and MD+3 in starters and non-starters following successful and unsuccessful matches revealed significant differences at MDpre and MDpost in starters, respectively. Furthermore, s-Cort values at MD-1, MDpre, MDpost and MD+3 in starters and non-starters in successful and unsuccessful matches revealed significant differences at MD+3 in starting players.

Discussion: The present study suggests that in elite level soccer players, both starting status and match outcome influence s-IgA and s-Cort responses, particularly starters. Specifically, s-IgA was lower for starters before and after the match following successful outcomes. Moreover, higher s-Cort values were found before the match while lower values occurred after the match for starters in successful matches.
Metabolomics reveal root differential metabolites of different root-type alfalfa under drought stress
Authors: Wang Kun , Nan Li-Li , Xia Jing , Wu Shi-Wen , Yang Li-Li
Published: January 2024

Introduction

Alfalfa (Medicago sativa L.) is the favored premium feed ingredient in animal husbandry production which is in serious jeopardy due to soil moisture shortages. It is largely unknown how different root types of alfalfa respond to arid-induced stress in terms of metabolites and phytohormones.

Methods

Therefore, rhizomatous rooted M. sativa ‘Qingshui’ (or QS), tap-rooted M. sativa ‘Longdong’ (or LD), and creeping rooted M. varia ‘Gannong No. 4’ (or GN) were investigated to identify metabolites and phytohormones responses to drought conditions.

Results

We found 164, 270, and 68 significantly upregulated differential metabolites were categorized into 35, 38, and 34 metabolic pathways in QS, LD, and GN within aridity stress, respectively. Amino acids, organic acids, sugars, and alkaloids were the four categories of primary differential metabolites detected, which include 6-gingerol, salicylic acid (SA), indole-3-acetic acid (IAA), gibberellin A4 (GA4), abscisic acid (ABA), trans-cinnamic acid, sucrose, L-phenylalanine, L-tyrosine, succinic acid, and nicotinic acid and so on, turns out these metabolites are essential for the resistance of three root-type alfalfa to aridity coercing.

Discussion

The plant hormone signal transduction (PST) pathway was dramatically enriched after drought stress. IAA and ABA were significantly accumulated in the metabolites, indicating that they play vital roles in the response of three root types of alfalfa to water stress, and QS and LD exhibit stronger tolerance than GN under drought stress.
Young SNP members: socio-nationalism, identity and politics
Authors: Breniaux Claire
Published: January 2024

Scotland is an interesting case study when it comes to politics, nationalism and identity. The separatist movement led by the Scottish National Party (SNP) raises a wide range of questions with regard to Scottish and British politics as well as people's sense of belonging. Given that young people are the generation most likely to witness a hypothetical second independence referendum in the future, this paper focuses on them. It examines the young members of the SNP. It explores the interconnection between Scottish politics and young SNP members' nationalism as well as their understanding of Scottishness. With the analysis of empirical research conducted from 2018 to 2020, it suggests that the Young Scots for Independence (YSI) and SNP Students' nationalism should be regarded as socio-nationalism. This paper defines it as the promotion of societal values and a certain perception of society combined with the promotion and defense of a nation. Interviews and questionnaires reveal that these young people define Scotland as socially just, equal and open. Overall, their definition of Scottishness is similar. In that sense, this paper argues that their political ideology and their sense of belonging are interrelated. This is highlighted by the fact that Scottish independence is, among other factors, the most significant reason why young people choose to become SNP members. It also highlights a relationship between their sense of Scottishness and their wish for Scotland to become independent. Therefore, this paper argues that young people's membership of the SNP and national identity are interrelated.
Multifaceted leaders: the double-edged sword effect of narcissistic leadership on employees’ work behavior
Authors: Chen Hao , Zhang Lei , Wang Liang , Bao Jiaying , Zhang Zihan
Published: January 2024

So far, most studies have focused on exploring the negative effects of narcissistic leadership. However, little attention has been paid to whether narcissistic leadership also has a positive effect. This study is based on Conservation of Resources Theory and reveals that narcissistic leadership has a double-edged sword effect. By using Mplus7.4 software the analysis of 450 employees and their direct leaders’ pairing data collected in three stages, it is found that: narcissistic leadership has a positive effect on employee’ hostility toward supervisor and psychological availability; hostility toward supervisor mediates the relationship between narcissistic leadership and counterproductive work behavior; psychological availability mediates the relationship between narcissistic leadership and organizational citizenship behavior; in addition, environmental uncertainty enhances the positive effect of narcissistic leadership on employee’ hostility toward supervisor and psychological availability, which in turn moderates the indirect effect of narcissistic leadership on counterproductive work behavior through employee’ hostility toward supervisor and on organizational citizenship behavior through psychological availability.
Color-taste correspondence tested by the Stroop task
Authors: Yang Yidie , Chen Na , Kobayashi Maiko , Watanabe Katsumi
Published: January 2024

People consistently associate colors with tastes (e.g., pink-sweet, yellow-sour). However, little has been known on the strength of those color-taste correspondences. The current study examined the congruency effect of color-taste correspondence using two Stroop word categorization tasks. The visual stimuli consisted of food names associated with sweet and sour tastes, presented in different shades of pink and yellow font colors. Participants were instructed to categorize the taste (sweet or sour) of the words in the Stroop word-taste categorization task and to discriminate the font color (pink or yellow) of the words in the Stroop word-color discrimination task. Results showed that participants responded faster in congruent conditions (sweet-pink and sour-yellow) than incongruent conditions (sweet-yellow and sour-pink) in both tasks. Specifically, yellow font colors facilitated the categorization of sour taste words compared to pink font colors, whereas sweet taste words facilitated the discrimination of pink font colors compared to sour taste words. These results provide further evidence for the congruency effect of color-taste correspondence in facilitating the processing of taste-related words and colors. Furthermore, the congruency effect was shown to operate bidirectionally, influencing both the conceptual meaning of tastes and perceptual color perception. This study highlights the significant interference effect of color-taste correspondence on cognitive processing as assessed by the Stroop task.
Mind over mood: exploring the executive function’s role in downregulation
Authors: Rodas Jose A. , Leon-Rojas Jose , Rooney Brendan
Published: January 2024

Emotion regulation plays a key role in well adapted behaviour, however, factors influencing individual differences in ER are still under investigation. Across two studies we investigate the complex relationship between executive functions (EFs) and emotional downregulation through two complementary research designs. The focus lies on key components of EFs—working memory, inhibitory control, and switching—and their relationship with effective emotional regulation. Surprisingly, switching emerged as the sole significant predictor in two multiple linear regression models, challenging the conventional belief that all major EFs broadly contribute to emotional downregulation. The first study, involving 248 Ecuadorian adults between 18 and 60 years old, used experimental tasks to assess the association between EFs and emotional regulation, aligning with existing literature that posits a link between EFs and emotional control. The second study, involving 180 Ecuadorian adults between 18 and 43 years old, added depth by incorporating self-report measures, providing a broader, ecologically valid perspective. However, these measures did not significantly predict downregulation, highlighting a gap between self-perception and actual cognitive abilities. Additionally, demographic predictors varied between the two studies, urging future research to consider methodological design and task selection carefully. The study also raises questions about the validity of commonly used measures, emphasising the need for more nuanced tools to capture the complexity of EFs and emotional regulation. Our findings suggest a targeted research avenue focusing on EFs for both future research and clinical interventions. Attention is called to the methodological decisions that can influence the observed associations, and the need for broader demographic representation in future studies.
Opioid use disorder: current trends and potential treatments
Authors: Lee Yu Kyung , Gold Mark S. , Blum Kenneth , Thanos Panayotis K. , Hanna Colin , Fuehrlein Brian S.
Published: January 2024

Opioid use disorder (OUD) is a major public health threat, contributing to morbidity and mortality from addiction, overdose, and related medical conditions. Despite our increasing knowledge about the pathophysiology and existing medical treatments of OUD, it has remained a relapsing and remitting disorder for decades, with rising deaths from overdoses, rather than declining. The COVID-19 pandemic has accelerated the increase in overall substance use and interrupted access to treatment. If increased naloxone access, more buprenorphine prescribers, greater access to treatment, enhanced reimbursement, less stigma and various harm reduction strategies were effective for OUD, overdose deaths would not be at an all-time high. Different prevention and treatment approaches are needed to reverse the concerning trend in OUD. This article will review the recent trends and limitations on existing medications for OUD and briefly review novel approaches to treatment that have the potential to be more durable and effective than existing medications. The focus will be on promising interventional treatments, psychedelics, neuroimmune, neutraceutical, and electromagnetic therapies. At different phases of investigation and FDA approval, these novel approaches have the potential to not just reduce overdoses and deaths, but attenuate OUD, as well as address existing comorbid disorders.
Socially connected while apart: the use of technology to increase social connection between nursing home residents and their relatives
Authors: Akhtar Sehrish Andleeb
Published: January 2024

Introduction

This study examines whether the use of a communication technology can enhance social connectedness among nursing home residents in Norway. The concept of social connectedness suggest that positive and significant interpersonal relationships can help reduce the risk of loneliness and social isolation among older adults and can be beneficial for both their health and overall well-being. In recent years, technology has been increasingly utilized as a method to overcome physical distances and to keep families connected. Although the use of digital solutions among older people has increased in recent years, few studies have addressed the use and impact of such technologies within a nursing home context.

Methods

A total of 225 residents participated in the study, making it one of the few quantitative studies that examine the use of communication technologies in nursing homes at such a large scale. The study combines two sources of data: (1) survey data collected over a 14-month period, in three different waves, at all public nursing homes in Oslo municipality and (2) a highly detailed weekly datastream from each Komp-device, which provides an objective measure of the frequency of contact between the residents and their families. The two sources of data were combined and analyzed using multiple regression analysis.

Results

The regression analysis revealed a positive and significant relationship between Komp use and increased social satisfaction among the residents. The results indicate that Komp is a feasible communication tool to help nursing home residents maintain relations with their families.

Discussion

The positive response to Komp among the residents suggests that when designed with the user’s needs in mind, technology can indeed facilitate meaningful social interactions, even for those with limited technological experience. Such interventions can thus be crucial in bridging the gap between older residents and the outside world, effectively addressing their unique challenges of social isolation and disconnection from the broader community.
The impact of modifiable health metrics on mortality for older adults with low cognitive function
Authors: Wang Wei , Sun Pengfei , Lv Tingting , Li Min
Published: January 2024

Objectives

Cognitive impairment has emerged as a major contributing factor to mortality for older adults. Identifying the strong modifiable health metrics against mortality is of high priority, especially in this high-risk population.

Methods

This population-based study used data of US adults aged≥60 years old from the National Health and Nutrition Examination Survey 2011–2014 cycles. De-identified data for participants who completed cognitive function test were extracted. Mortality data was obtained by linking to the 2019 public-use linked mortality file.

Results

Participants with low global cognition had higher risk of all-cause mortality (HR = 1.46; 95%CI, 1.04–2.05). The highest prevalence of ideal level of health metrics was observed for sleep duration (54.36% vs. 62.37%), and the lowest was noted for blood pressure (12.06% vs. 21.25%) for participants with low and average to high global cognition, respectively. Ideal status of physical activity and diet quality were significantly associated with all-cause mortality among participants with low global cognition (HR = 0.48, 95%CI: 0.28–0.82; HR = 0.63, 95%CI: 0.43–0.95). The corresponding population-attributable fractions were 26.58 and 15.90%, respectively.

Conclusion

Low cognitive function was associated with increased risk of all-cause death for older adults. Attainment of healthy metrics, especially sufficient physical activity, consuming healthy diet and being never smoked, provided strong protection against death risk.
Mediating effect of sleep quality on the association between job stress and health-related productivity loss among workers in R&D enterprises in Shanghai
Authors: Sun Yixuan , Wei Minqi , Zhao Qiuwen , Yang Jinfeng , Gao Junling , Dai Junming
Published: January 2024

Background

Past research indicates that occupational stress negatively predicts health-related productivity. Simultaneously, sleep problem among workers may stem from job stress, subsequently leading to a decline in sleep quality and resulting in reduced health productivity. Therefore, this study aims to idenitify whether the sleep quality of employees functions as a mediator in the process through which job stress impacts health productivity.

Objectives

This study aimed to assess the status and analyze differences in quality of sleep, job stress, and health-related productivity loss (HRPL) among workers in research and development (R&D) enterprises in Minhang District, Shanghai. We also assessed the mediating effect of sleep quality on the relationship between job stress and HRPL.

Methods

A total of 3,216 workers in R&D firms aged between 18 and 60 years participated in this study (mean age 35.15 years; standard deviation 8.44; male-to-female ratio≈2:1). The Nakata Insomnia Questionnaire, the Chinese version of the Brief Job Stress Questionnaire revised edition, and the Chinese version of the Work Productivity and Activity Impairment Questionnaire were used in this study. And the Kruskal–Wallis test, Hierarchical Multiple Regression Analysis, and Path Analysis were utilized for data analysis in this study.

Results

There were significant differences in the positive detection rate of insomnia among participants according to age, educational level, marital status, position, length of service, and level of financial difficulties (all P < 0.05). We also found significant differences in the positive detection rate of HRPL among participants according to age, marital status, length of service, and level of financial difficulties (all P < 0.05); participants with insomnia scored higher for HRPL than those without insomnia (6.00 vs. 4.20, P < 0.001). Additionally, participants with job stress problems had higher HRPL than those without these issues (7.00 vs. 4.20, P < 0.001). Our findings suggest that sleep quality plays a mediating role between job stress and HRPL (all P < 0.05).

Conclusions

Occupational health professionals must pay particular attention to job stress, sleep quality, and their influencing factors to positively influence the wellbeing of workers while improving productivity.
Serosurvey of Toxoplasma gondii and Toxocara spp. co-infection in pregnant women in low-income areas of Brazil
Authors: Pereira Edlayne Larissa Gretter Machado , Ferreira Isabella Braghin , Victorino Roberta Brinholi , Lescano Susana Angélica Zevallos , Giuffrida Rogério , Kmetiuk Louise Bach , Biondo Alexander Welker , Santarém Vamilton Alvares
Published: January 2024

Introduction

Despite human toxoplasmosis and toxocariasis having been listed among the top six most neglected parasitic zoonoses worldwide, presenting similar associated risk factors and transmission routes, few studies have been conducted in pregnant women and the consequences of concurrent infection remain to be fully established. Accordingly, the present study has serologically assessed the co-infection and associated risk factors for Toxoplasma gondii and Toxocara spp. in pregnant women, assisted by the public Unified National Health System (SUS) in southeastern Brazil.

Materials and Methods

Blood samples were collected and tested for IgG antibodies against Toxoplasma gondii by chemiluminescence immunoassay and against Toxocara spp. by enzyme-linked immunosorbent assay (ELISA). An epidemiological questionnaire was applied to gather socioeconomic information to assess the risk factors associated with seropositivity to toxocariasis/toxoplasmosis by univariate analysis followed by logistic regression.

Results

Overall, seropositivity was 69/280 (24.6, 95% CI: 19.96–30.01) for T. gondii and 56/280 (20.0, 95% CI: 15.73–25.08) for Toxocara spp. Co-infection was observed in 25/280 (8.9, 95% CI: 6.12–12.85) pregnant women, with increased odds (OR: 3.3, CI 95%: 1.77–6.14, p = 0.0002). Logistic regression revealed that a higher educational level (high school or college) significantly reduced the likelihood of co-infection seropositivity, owning cats increased the odds of toxocariasis, and older pregnant women presented significantly higher T. gondii seropositivity.

Conclusion

Co-infection herein highlights the importance of educational programs in the prevention of toxocariasis and toxoplasmosis in pregnant women and other high-risk populations.
The Math Behind the Movies
Authors: Hanrahan Pat
Published: January 2024

Have you ever wondered why the things you see around you look the way they do? A big part of my work as a computer graphics researcher is to answer this question, so that we can simulate real-world objects using computers. This work is important for creating movies and video games that are visually appealing to the audience. However, there are also many other applications of realistic computer graphics, such as training, product design, architecture, and others. In this article, I will tell you how we create realistic images of the world using computers, and how my work improved the way we simulate skin and hair in virtual characters. It will give you a new perspective on the magic and beauty of the visual scenery that we experience in our everyday lives and on the computer-generated images and movies that imitate these natural scenes.
Prevalence and antimicrobial resistance of Enterococcus spp. isolated from animal feed in Japan
Authors: Yamagami Yohei , Asao Miyuki , Takahashi Akiko , Hashimoto Yoshiyasu , Okuyama Noriko , Arai Eiko , Arihara Wakana , Masui Ryota , Shimazaki Yoko
Published: January 2024

The rising prevalence of antimicrobial resistance (AMR) of bacteria is a global health problem at the human, animal, and environmental interfaces, which necessitates the “One Health” approach. AMR of bacteria in animal feed are a potential cause of the prevalence in livestock; however, the role remains unclear. To date, there is limited research on AMR of bacteria in animal feed in Japan. In this study, a total of 57 complete feed samples and 275 feed ingredient samples were collected between 2018 and 2020. Enterococcus spp. were present in 82.5% of complete feed (47/57 samples), 76.5% of soybean meal (62/81), 49.6% of fish meal (55/111), 33.3% of poultry meal (22/66), and 47.1% of meat and bone meal (8/17) samples. Of 295 isolates, E. faecium (33.2% of total isolates) was the dominant Enterococcus spp., followed by E. faecalis (14.2%), E. hirae (6.4%), E. durans (2.7%), E. casseliflavus (2.4%), and E. gallinarum (1.0%). Of 134 isolates which were tested for antimicrobial susceptibility, resistance to kanamycin was the highest (26.1%), followed by erythromycin (24.6%), tetracycline (6.0%), lincomycin (2.2%), tylosin (1.5%), gentamicin (0.8%), and ciprofloxacin (0.8%). All Enterococcus spp. exhibited susceptibility to ampicillin, vancomycin, and chloramphenicol. Of 33 erythromycin-resistant isolates, only two showed a high minimum inhibitory concentration value (>128 μg/mL) and possessed ermB. These results revealed that overall resistance to antimicrobials is relatively low; however, animal feed is a source of Enterococcus spp. It is essential to elucidate the causative factors related to the prevalence of AMR in animal feed.