bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimising the reintroduction of a specialist peatland butterfly Coenonympha tullia onto peatland restoration sites
Authors: Osborne Andrew , Griffiths Sarah , Caporn Simon , Coulthard Emma
Published: May 2024

The two main goals of peatland restoration are habitat improvement and climate change mitigation by reducing greenhouse gas emissions from damaged peatlands and providing a net carbon sink. The biodiversity of specialist peatland species is threatened because of habitat destruction and the large heath butterfly Coenonympha tullia has become a flagship species for peatland ecosystem restoration, with a species reintroduction programme currently underway on a peatland restoration site within Chat Moss, Greater Manchester, UK. The aim of this study was to improve our quantitative understanding of C. tullia habitat resource requirements to optimise habitat restoration for further reintroduction attempts. We monitored butterfly micro-distribution and dispersal during the first three flight seasons (2020, 2021 and 2022) of the reintroduction using high-accuracy GPS, combined with a distance-bearing protocol. Analysis of butterfly flight points and rest points in relation to plant species distribution and abundance, identified the most important habitat resources. Using logistic regression, treatment-response curves were constructed, enabling us to identify critical thresholds for the abundance of these important habitat resources. The break of slope near the top of the logistic curve was identified using segmented regression, giving an estimate of the near-optimal abundance; fourteen Eriophorum vaginatum tussocks per 2 m quadrat and 13.4% Erica tetralix cover.

Implications for insect conservation

During ecosystem restorations, prior to the reintroduction of species with specialist habitat requirements, it is necessary to have a clear understanding of the abundance of the important habitat resources that need to be provided. The quantitative approach we describe defines the most significant environmental factors and habitat resources, then uses segmented regression to estimate the near-optimal habitat resource requirements; increasing the likelihood of reintroduced populations thriving and reintroduction programmes achieving long-term success.
Labeling of methyl groups: a streamlined protocol and guidance for the selection of 2H precursors based on molecular weight
Authors: Locke Alexandra , Guarino Kylee , Rule Gordon S.
Published: May 2024

A streamlined one-day protocol is described to produce isotopically methyl-labeled protein with high levels of deuterium for NMR studies. Using this protocol, the D2O and 2H-glucose content of the media and protonation level of ILV labeling precursors (ketobutyrate and ketovalerate) were varied. The relaxation rate of the multiple-quantum (MQ) state that is present during the HMQC-TROSY pulse sequence was measured for different labeling schemes and this rate was used to predict upper limits of molecular weights for various labeling schemes. The use of deuterated solvents (D2O) or deuterated glucose is not required to obtain 1H–13C correlated NMR spectra of a 50 kDa homodimeric protein that are suitable for assignment by mutagenesis. High quality spectra of 100–150 kDa proteins, suitable for most applications, can be obtained without the use of deuterated glucose. The proton on the β-position of ketovalerate appears to undergo partial exchange with deuterium under the growth conditions used in this study.
Reaching the Top? Profiles of Impression Management and Career Success
Authors: Debus Maike E. , Ingold Pia V. , Gross Christian , Bolino Mark C.
Published: May 2024

Employees use impression management (IM) tactics to influence their image at work. Whereas findings regarding the effects of IM on interview outcomes and performance evaluations are extensive, our understanding of the career implications of IM is both limited and inconclusive. In this two-study paper, we used latent profile analysis to better understand the relationship between the use of five IM tactics in combination—ingratiation, self-promotion, exemplification, intimidation, and supplication—and multiple indicators of objective career success (i.e., salary, promotions, and supervisor-rated reward recommendations) and subjective career success. Four different IM profiles were identified in a sample of 237 employees in Study 1 and which were replicated in Study 2 with 268 employees. In Study 1, we found that the highest levels of salaries and promotions (reflecting objective career success) were associated with a passive use of IM (i.e., employing all five IM strategies at low frequency), thereby running counter to our initial expectations. In contrast, the highest level of subjective career success was associated with a positive use of IM (i.e., a pattern employing the three positive strategies ingratiation, self-promotion and exemplification at higher levels). In Study 2, we found positive use of IM to be associated with the highest level of supervisor-rated reward recommendations as a further indicator of objective career success (followed by passives with the second highest reward recommendations). Our findings highlight the importance of viewing objective and subjective career success as qualitatively different constructs and suggest benefits of employing passive IM use for objective career success.
A Design Method of an Ultra-Wideband and Easy-to-Array Magic-T: A 6-14 GHz Scaled Model for a mm/submm Camera
Authors: Inoue Shuhei , Chin Kah Wuy , Uno Shinsuke , Kohno Kotaro , Niwa Yuka , Naganuma Toyo , Yamamura Ryosuke , Watanabe Kazuki , Takekoshi Tatsuya , Oshima Tai
Published: May 2024

We established a design method for a Magic-T with a single-layer dielectric/metal structure suitable for both wideband and multi-element applications for millimeter and submillimeter wave imaging observations. The design method was applied to a Magic-T with a coupled-line, stubs, and single-stage impedance transformers in a frequency-scaled model (6–14 GHz) that is relatively easy to demonstrate through manufacturing and evaluation. The major problem is that using the conventional perfect matching condition for a coupled-line alone produces an impractically large width coplanar coupled-line (CPCL) to satisfy the desired bandwidth ratio. In our study, by removing this constraint and optimizing impedances utilizing a circuit simulator with high computation speed, we found a solution with a $$\sim$$
∼
180 μm wide CPCL, which is approximately an order of magnitude smaller than the conventional analytical solution. Furthermore, considering the effect of transition discontinuities in the transmission lines, we optimized the line length and obtained a design solution with return loss < − 20 dB, amplitude imbalance < 0.1 dB, and phase imbalance < 0.5$$^{\circ }$$

∘

from 6.1 to 14.1 GHz.
How Do Teachers Collaborate in Informal Professional Learning Activities? An Epistemic Network Analysis
Authors: Fütterer Tim , Omarchevska Yoana , Rosenberg Joshua M. , Fischer Christian
Published: May 2024

Teachers turn to many sources for support and professional learning, including social media-based communities that have shown promise to help teachers access resources and facilitate productive exchanges. Although such online communities show promise, questions about their quality for providing a suitable learning environment remain insufficiently answered. In this study, we examine how teachers’ engagement on Twitter (now known as “X”) may adhere to characteristics of high-quality professional development (PD) activities. In that, we employ advanced conversational analysis techniques that extend the primarily descriptive methods used in prior research. Specifically, we collected data from three Twitter communities related to Advanced Placement Biology (N = 2,040 tweets, N = 93 teachers). Qualitative two-cycle content analyses derived both tweet content and sentiment. Using epistemic network analyses, we examined the collaborative structures to examine how participation patterns can identify characteristics of high-quality online PD. Results indicate that some teachers use Twitter with a content focus and coherent to their individual contexts and prior knowledge. Notably, differences in collaboration and participation patterns by teachers’ overall activity level hint at the existence of an online community of practice. More active teachers communicated more about how their individual contexts relate to instruction, whereas less active teachers exhibited more targeted engagement, for instance, related to sharing teaching resources and organizing learning opportunities. Overall, this study illustrates how Twitter may provide a meaningful learning environment to teachers so that it can serve as a relevant avenue for their professional learning.
The Relation between Residential Mobility and Internalizing and Externalizing Problems in Adolescence: The Role of Subjective Moving Experience, Gender, and Friendship Quality
Authors: Henkens Juul H. D. , Stevens Gonneke W. J. M. , de Valk Helga A. G.
Published: May 2024

Adolescent residential mobility can be a stressful life event, potentially aggravating internalizing or externalizing problems. However, the longitudinal effects of residential mobility are understudied and may be context-dependent. This study investigates the longitudinal associations between adolescent residential mobility and internalizing and externalizing problems. Additionally, this study examines for whom residential moves are most detrimental by including subjective moving experience, gender, and friendship quality before the move as moderators. Longitudinal data from 2,029 adolescents (51% female) from the TRacking Adolescents’ Individual Lives Survey (TRAILS) were used (Mage [SD] at T1 = 11.1 [0.55], T2 = 13.6 [0.52], and T3 = 16.3 [0.70]). Results from stepwise multi-level random-effect models showed that adolescents who experienced an unpleasant move remained stable in internalizing problems, while others decreased over time. Adolescents who moved increased stronger in externalizing problems than adolescents who did not move, independent of whether they experienced the move as unpleasant. Gender and friendship quality before the move did not moderate the relation between residential mobility and internalizing or externalizing problem development. These results emphasize that residential moves in adolescence, especially when experienced as unpleasant, can have long-lasting negative effects on adolescent development.
Structural heterogeneity predicts ecological resistance and resilience to wildfire in arid shrublands
Authors: Zaiats Andrii , Cattau Megan E. , Pilliod David S. , Liu Rongsong , Dumandan Patricia Kaye T. , Hojatimalekshah Ahmad , Delparte Donna M. , Caughlin T. Trevor
Published: May 2024

Context

Dynamic feedbacks between physical structure and ecological function drive ecosystem productivity, resilience, and biodiversity maintenance. Detailed maps of canopy structure enable comprehensive evaluations of structure–function relationships. However, these relationships are scale-dependent, and identifying relevant spatial scales to link structure to function remains challenging.

Objectives

We identified optimal scales to relate structure heterogeneity to ecological resistance, measured as the impacts of wildfire on canopy structure, and ecological resilience, measured as native shrub recruitment. We further investigated whether structural heterogeneity can aid spatial predictions of shrub recruitment.

Methods

Using high-resolution imagery from unoccupied aerial systems (UAS), we mapped structural heterogeneity across ten semi-arid landscapes, undergoing a disturbance-mediated regime shift from native shrubland to dominance by invasive annual grasses. We then applied wavelet analysis to decompose structural heterogeneity into discrete scales and related these scales to ecological metrics of resilience and resistance.

Results

We found strong indicators of scale dependence in the tested relationships. Wildfire effects were most prominent at a single scale of structural heterogeneity (2.34 m), while the abundance of shrub recruits was sensitive to structural heterogeneity at a range of scales, from 0.07 – 2.34 m. Structural heterogeneity enabled out-of-site predictions of shrub recruitment (R2 = 0.55). The best-performing predictive model included structural heterogeneity metrics across multiple scales.

Conclusions

Our results demonstrate that identifying structure–function relationships requires analyses that explicitly account for spatial scale. As high-resolution imagery enables spatially extensive maps of canopy heterogeneity, models for scale dependence will aid our understanding of resilience mechanisms in imperiled arid ecosystems.
Structuralizing Culture: Multicultural Neoliberalism, Migration, and Mental Health in Santiago, Chile
Authors: Abarca-Brown Gabriel
Published: May 2024

The arrival of Afro-descendant migrants, mainly from Haiti and the Dominican Republic, has led to the emergence of new discourses on migration, multiculturalism, and mental health in health services in Chile since 2010. In this article, I explore how mental health institutions, experts, and practitioners have taken a cultural turn in working with migrant communities in this new multicultural scenario. Based on a multisited ethnography conducted over 14 months in a neighbourhood of northern Santiago, I focus on the Migrant Program—a primary health care initiative implemented since 2013. I argue that health practitioners have tended to redefine cultural approaches in structural terms focusing mainly on class aspects such poverty, social stratification, and socioeconomic inequalities. I affirm that this structural-based approach finds its historical roots in a political and ideological context that provided the conditions for the development of community psychiatry experiences during the 1960s and 1970s, as well as in multicultural and gender policies promoted by the state since the 1990s. This case reveals how health institutions and practitioners have recently engaged in debates on migration and intersectionality from a structural approach in Chile.
A new kinematic model for revolute clearance joints with noncircular bushing and pin in planar multibody systems
Authors: Liu Zhe , Zhang Heng , Meng Lu , Sun Yu , Luo Sihai , Zhou Liucheng , Li Pei
Published: May 2024

Due to manufacturing error and wear, the profiles of bushing and pin in revolute clearance joints are usually non-circular, while traditional kinematic models for revolute clearance joints generally assume a circular profile for the pin or bushing, which may not be able to accurately capture the kinematic behavior of real revolute joints in multibody systems. To this end, a curvature center method was proposed for the kinematic modeling of revolute clearance joints with noncircular bushing and pin. In the proposed method, both the noncircular bushing and pin were discretized, and the curvature center and radius corresponding to each discrete point were then obtained to detect the point of contact between the bushing and pin based on their kinematic constraints. The number of discrete points was determined based on both accuracy and efficiency of the proposed curvature center method, which was then applied to model a revolute clearance joint between the slider and the link of a slider-crank mechanism. Via comparison to the traditional geometric center method and discrete point method, it was validated that the proposed method can achieve a comparable accuracy in modeling revolute joints with a circular pin. The unique advantage of the proposed curvature center method is its ability in modeling revolute joints with noncircular bushing and noncircular pin, which was also demonstrated via a series of simulations. Simulation results show a significant influence of noncircular bushing and noncircular pin on the dynamic response of the multibody system. This implies the promising value of the proposed method in studying the effect of manufacturing error or wear of both bushing and pin on the system’s dynamic performance and/or service life.
Exploring potential influencing factors of inadherence to specialist aftercare and long-term medication in patients with acromegaly
Authors: Siegel Sonja , Giese Sabrina , Honegger Jürgen , Friedel Anna Lena , Grzywotz Agnieszka , Wrede Karsten Henning , Sure Ulrich , Unger Nicole , Kreitschmann-Andermahr Ilonka
Published: May 2024

Purpose

To improve the understanding of adherence as one major factor of disease control in acromegaly patients, we systematically assessed patients’ motivations to adhere to advised follow-up schedules and recommended medication for acromegaly.

Methods

Cross-sectional, postal questionnaire study on adult patients with acromegaly, operated upon a growth hormone producing pituitary adenoma more than 1 year ago in two tertiary treatment centers. We assessed demographic and clinical characteristics, disease status, adherence to acromegaly medication and/or aftercare, and the five dimensions defined by the World Health Organization influencing adherence. Wherever applicable, we included validated short scales. The answers of 63 patients (33 f, 30 m; mean age 56.1 y) were analyzed.

Results

Patients with problems in adherence to aftercare had a significantly lower subjective symptomload than those adherent to aftercare (p = 0.026) and a lower perceived need for treatment (p = 0.045). Patients with adherence problems to medication had a higher subjective symptomload than those without (p = 0.056). They also tended to have shorter consultations, were significantly more often dissatisfied with the duration of their medical consultations (42% vs 4.8%, p = 0.019) and tended to find that their physician explained potential difficulties with adherence less well than patients without adherence problems (p = 0.089).

Conclusions

To our knowledge, this is the first study which explored adherence to medication and aftercare in patients with acromegaly, taking into account potential influencing factors from all areas defined by the WHO model of adherence. Of the modifiable factors of adherence, patient–doctor relationship seemed to play a crucial role and could be one leverage point to improve adherence.
Predictors of Chinese reading in Chinese monolingual and Chinese–English bilingual children in Mainland China
Authors: Zang Xuan , Wong Yu Ka , Lau Kit-ling
Published: May 2024

There is a growing number of children learning to read in bilingual environments, yet research on the uniqueness of reading acquisition in these bilingual children, particularly L1 majority bilinguals, is limited. With a sample size of 690 4th-grade students, this study investigated predictors influencing L1 Chinese reading in Chinese–English bilingual children (n = 345) attending Chinese–English bilingual schools in mainland China and made comparisons with their monolingual counterparts (n = 345). The results of a multi-group path analysis revealed both similarities and differences between the two groups. In terms of Chinese reading comprehension, word reading and linguistic comprehension were significant predictors for both groups, but their relative importance differed. While there was no difference in the predictive power between the two predictors in the monolingual group, word reading held a greater contribution in the bilingual group. Regarding Chinese word reading, both morphological and orthographic awareness emerged as significant predictors in the monolingual group, whereas in the bilingual group, only morphological awareness was significant, and the contribution of phonological awareness was insignificant in either group. These findings underscore the distinct relationship between reading and its predictive constituents in bilingual students when compared to their monolingual counterparts.
Sewage Derived Microplastic and Anthropogenic Fibre Retention by Integrated Constructed Wetlands
Authors: Warren Richard J. , Cooper Richard J. , Mayes Andrew G. , Nolte Stefanie , Hiscock Kevin M. , Tosney Jonah
Published: May 2024

High loads of microplastics and anthropogenic fibres can be discharged from wastewater treatment plants (WWTPs) into surface water bodies. Integrated Constructed Wetlands (ICWs) are potentially well suited to provide a cost-effective mitigation solution at small WWTPs where conventional treatment is prohibitively expensive. This study aimed to assess the microplastic and anthropogenic fibre retention efficiency of two ICWs (Northrepps and Ingoldisthorpe) in Norfolk (UK) over a 12-month period (2022–2023). Analysing a total of 54 water and 23 sediment samples, the findings revealed that Northrepps ICW received on average 349,920 (± 763,776) anthropogenic fibres day−1, with a retention rate of 99.3%. No seasonal variation was observed in retention efficiency. Ingoldisthorpe ICW intermittently received anthropogenic fibres in low concentrations, with an average of 9504 (± 19,872) day−1 and a retention rate of 100%. Microplastics and anthropogenic fibres were prevalent in sediment samples of the first cell of Northrepps ICW, averaging 10,090 items kg−1 dry sediment, while none were found at concentrations above the limit of detection in the second or third cell. Of the 369 fibres analysed by ATR-FTIR, 55% were plastic (dominated by polyester). Of the 140 suspected microplastic fragments analysed by ATR-FTIR, 73% were confidently identified as plastic (mostly polystyrene, polyethylene, or polypropylene). This study demonstrates how ICWs can effectively retain sewage effluent derived microplastics and anthropogenic fibres. However, the accumulation of plastic waste in ICWs may complicate long term management and their cost-effectiveness.
Cloud storage cost: a taxonomy and survey
Authors: Khan Akif Quddus , Matskin Mihhail , Prodan Radu , Bussler Christoph , Roman Dumitru , Soylu Ahmet
Published: May 2024

Cloud service providers offer application providers with virtually infinite storage and computing resources, while providing cost-efficiency and various other quality of service (QoS) properties through a storage-as-a-service (StaaS) approach. Organizations also use multi-cloud or hybrid solutions by combining multiple public and/or private cloud service providers to avoid vendor lock-in, achieve high availability and performance, and optimise cost. Indeed cost is one of the important factors for organizations while adopting cloud storage; however, cloud storage providers offer complex pricing policies, including the actual storage cost and the cost related to additional services (e.g., network usage cost). In this article, we provide a detailed taxonomy of cloud storage cost and a taxonomy of other QoS elements, such as network performance, availability, and reliability. We also discuss various cost trade-offs, including storage and computation, storage and cache, and storage and network. Finally, we provide a cost comparison across different storage providers under different contexts and a set of user scenarios to demonstrate the complexity of cost structure and discuss existing literature for cloud storage selection and cost optimization. We aim that the work presented in this article will provide decision-makers and researchers focusing on cloud storage selection for data placement, cost modelling, and cost optimization with a better understanding and insights regarding the elements contributing to the storage cost and this complex problem domain.
A heterogeneous graph-based semi-supervised learning framework for access control decision-making
Authors: Yin Jiao , Chen Guihong , Hong Wei , Cao Jinli , Wang Hua , Miao Yuan
Published: May 2024

For modern information systems, robust access control mechanisms are vital in safeguarding data integrity and ensuring the entire system’s security. This paper proposes a novel semi-supervised learning framework that leverages heterogeneous graph neural network-based embedding to encapsulate both the intricate relationships within the organizational structure and interactions between users and resources. Unlike existing methods focusing solely on individual user and resource attributes, our approach embeds organizational and operational interrelationships into the hidden layer node embeddings. These embeddings are learned from a self-supervised link prediction task based on a constructed access control heterogeneous graph via a heterogeneous graph neural network. Subsequently, the learned node embeddings, along with the original node features, serve as inputs for a supervised access control decision-making task, facilitating the construction of a machine-learning access control model. Experimental results on the open-sourced Amazon access control dataset demonstrate that our proposed framework outperforms models using original or manually extracted graph-based features from previous works. The prepossessed data and codes are available on GitHub,facilitating reproducibility and further research endeavors.
Algal-based bioplastics: global trends in applied research, technologies, and commercialization
Authors: Mogany Trisha , Bhola Virthie , Bux Faizal
Published: May 2024

The excessive global demand for plastic materials has resulted in severe plastic waste pollution. Conventional plastics derived from non-renewable fossil fuels are non-biodegradable, leading to significant environmental problems. Algal-based bioplastics represent a more viable, renewable, and sustainable alternative to conventional plastics. They have identical properties and characteristics as conventional plastics while being naturally biodegradable. The potential of the algal biomass value chain has already been well-established by researchers. Here, we review the novel insights on research, technology, and commercialization trends of algal-based bioplastics, encompassing macroalgae and green microalgae/cyanobacteria. Data showed that within the last decade, there has been substantial interest in utilizing microalgae for biopolymer production, with more focus on using cyanobacterial species compared to green algae. Moreover, most of the research conducted has largely focused on the production of PHA or its co-polymers. Since 2011, there have been a total of 55 patents published related to algal-based bioplastics production. To date, ~ 81 entities worldwide (commercial and private businesses) produce bioplastics from algae. Overall results of this study emphasized that even with the economic and social challenges, algae possess a substantial potential for the sustainable development of bioplastics while also addressing the UN’s SDGs.
Lateral load-carrying mechanism of driven battered minipiles
Authors: Mondal Sanchari , Disfani Mahdi M.
Published: May 2024

The lateral load-carrying mechanism of vertically installed and battered minipiles is evaluated using 1g-physical and numerical modelling. Single minipiles with batter angles of 0°, ± 25° and ± 45° are tested under lateral load in medium dense and dense sand. The minipiles are instrumented with fibre Bragg grated optic fibres to obtain a strain profile (two-dimensional) along the minipile shaft. A calibrated numerical model is further adopted to produce p–y curves for battered minipiles at various node deflections. The ratio of soil reaction of battered minipiles to vertically installed minipiles is observed to change with both deflection and depth of the minipile. An analytical solution is developed based on the decomposition of lateral load into skin friction and passive pressure for battered minipiles. A reduction factor is proposed that considers a decrease in passive pressure when the minipile is loaded in the opposite direction of the batter. The analytical solution is capable of accounting for soil properties, pile rigidity and the angle of inclination of battered minipiles. The analytical method is subsequently verified for cohesive soils using full-scale field results. The ratio of the ultimate lateral load of battered minipiles to vertical minipiles presented in the literature corroborated the findings of this study.
Increased anterior insula connectivity associated with cognitive maintenance in amnestic mild cognitive impairment: a longitudinal study
Authors: Li Hui , Fan Xiang , Li Kuncheng , Zhang Chen , Jia Xiuqin
Published: May 2024

The insula, a crucial hub of the human brain network, can be divided into anterior and posterior regions. Previous studies have reported that different insula subregions play various roles in amnestic mild cognitive impairment (aMCI). However, the longitudinal changes in the functional connectivity (FC) of each insula subregion in aMCI patients over time remain unclear. Twenty aMCI patients and 20 healthy controls (HCs) were recruited and underwent resting-state functional magnetic resonance imaging (fMRI) scans and neuropsychological assessments at baseline and at the 15-month follow-up. FMRI data were preprocessed using SPM 12 and the CONN toolbox. Two-way analysis of covariance was used to compare longitudinal changes in the FC of each insula subregion with covariates including sex, age, education, follow-up interval, volume of gray matter, and global correlation (GCOR). Pearson’s correlation was used to evaluate the relationship between insula subregional FC and neuropsychological performance in aMCI patients. In aMCI patients, the right anterior insula exhibited significantly increased FC with the left anterior cingulate cortex, whereas the left posterior insula exhibited decreased FC with the right precuneus compared with HCs. Furthermore, FC between the right anterior insula and left anterior cingulate cortex was significantly correlated with global cognition at follow-up. The current findings revealed different functional alterations in the insula subregions and provided new insights into the neurodegenerative process in aMCI patients.
Subjective well-being and inequality in Spain’s decline
Authors: Álvarez-Nogal Carlos , Prados de la Escosura Leandro
Published: May 2024

The economic decline of Early Modern Spain offers an opportunity to explore how it affected perceptions of welfare and inequality. We provide an answer based on the Bull of the Crusade, an inexpensive alms collected by the Hispanic Monarchy and massively purchased by a highly religious population that believed in its spiritual benefits. The purchase of the bull represented a public practice of religion that captured people’s religiosity and belief in the afterlife and had a positive impact on their spiritual well-being. We find that our measure of spiritual well-being—the ratio of (normalized) bulls sold to their recipients (the population aged 12 and above)—deteriorated in the late 1570s and 1580s and the 1640s but improved during the 1670s, while subjective inequality—the ratio between the number of bulls sold to those who deemed themselves affluent and those sold to common individuals—increased from 1600–1640 and fell in the 1580s and early 1590s and the 1670s. Hence, improving (deteriorating) subjective well-being was accompanied by declining (improving) subjective inequality through the seventeenth century.
Epistemic Trust in Scientific Experts: A Moral Dimension
Authors: Barimah George Kwasi
Published: May 2024

In this paper, I develop and defend a moralized conception of epistemic trust in science against a particular kind of non-moral account defended by John (2015, 2018). I suggest that non-epistemic value considerations, non-epistemic norms of communication and affective trust properly characterize the relationship of epistemic trust between scientific experts and non-experts. I argue that it is through a moralized account of epistemic trust in science that we can make sense of the deep-seated moral undertones that are often at play when non-experts (dis)trust science.
Comparison of Different Spectral Ranges to Monitor Alcoholic and Acetic Fermentation of Red Grape Must Using FT-NIR Spectroscopy and PLS Regression
Authors: Menozzi Camilla , Foca Giorgia , Calvini Rosalba , Catellani Lisa , Bezzecchi Andrea , Ulrici Alessandro
Published: May 2024

Wine vinegar is produced through a two-phase fermentation of grape must: initially, yeast converts grape sugars into ethanol, and subsequently, acetobacteria oxidize ethanol into acetic acid. This process, spanning weeks when conducted by surface fermentation, requires constant monitoring of ethanol and total acidity levels. To enhance the quality and efficiency of process monitoring, vinegar production is shifting to faster, environmentally sustainable methods. Near-infrared (NIR) spectroscopy, recognized for its non-invasiveness and speed, is ideal for online implementation in process control. This study tracked dual fermentation in red grape must over an extended period, monitoring two different batches simultaneously to assess fermentation kinetics and reproducibility. Ethanol content and total acidity were analyzed in fermenting musts throughout the whole fermentation process using both classical laboratory analyses and FT-NIR spectroscopy. Principal Component Analysis (PCA) was used to explore the spectral dataset, then Partial Least Squares (PLS) was used to develop calibration models for predicting ethanol and acidity. The models calculated considering the entire spectral range were compared with those obtained for two narrower zones, where more cost-effective and easily miniaturizable sensors are available on the market. FT-NIR allowed to effectively determine ethanol content and acidity (R2Pred > 0.98), both over the entire range (12,500–4000 cm−1, corresponding to 800–2500 nm) and in the 10,526–6060 cm−1 (950–1650 nm) region. Although less satisfactory, still acceptable results were obtained in the 12,500–9346 cm−1 (800–1070 nm) region (R2Pred > 0.81), confirming the potential for cost-effective devices in real-time fermentation monitoring.
Mixed neuroendocrine–non-neuroendocrine neoplasm of the bile duct with long-term prognosis after neoadjuvant chemotherapy
Authors: Nakamura Shinya , Serikawa Masahiro , Ishii Yasutaka , Tatsukawa Yumiko , Ikemoto Juri , Miyamoto Sayaka , Uemura Kenichiro , Takahashi Shinya , Arihiro Koji , Oka Shiro
Published: May 2024

A 74-year-old man with obstructive jaundice presented with a thickened distal bile duct wall. A transpapillary forceps biopsy revealed an adenocarcinoma; however, because the tumor image was different from that of a typical cholangiocarcinoma, endoscopic ultrasound-guided fine-needle aspiration was performed on the tumor and enlarged lymph nodes. The tumor cells were positive for synaptophysin and CD56 with a Ki67 labeling index of 95%, and he was diagnosed with small cell neuroendocrine carcinoma. We diagnosed a bile duct tumor with neuroendocrine carcinoma component with lymph node metastasis. Preoperative chemotherapy for neuroendocrine carcinoma was administered because R0 resection was difficult and the risk of postoperative recurrence was high. Three courses of chemotherapy with carboplatin and etoposide resulted in marked tumor shrinkage, and radical resection was performed 3 months after diagnosis. Postoperative pathology revealed adenocarcinoma in the mucosal epithelium and small cell neuroendocrine carcinoma in the submucosa, most of which resolved with chemotherapy. Carboplatin and etoposide were resumed as adjuvant chemotherapy, and 67 months of recurrence-free survival were achieved after surgery.
Getting the Most Out of Every Training Day: The Influence of Instructors on Self-Regulated Learning During Firefighter Leadership Courses
Authors: Röseler Stefan , Hilbert Micha , Hertel Guido , Thielsch Meinald T.
Published: May 2024

Leadership courses in the fire services are highly challenging, and they can seriously exhaust trainees and hamper their self-regulated learning efforts (for example, setting goals, focusing attention, seeking feedback). We theorize that experiences of failure or overload can curtail trainees’ available energy resources on subsequent training days, which, in turn, should affect trainees’ learning efforts. Given instructors’ central role in leadership courses, we hypothesize that supportive and humble instructor behaviors decrease experiences of failure and overload and, thus, increase self-regulated learning. Moreover, we argue that supportive instructor behavior may amplify the positive effects of high energy resources, while humble behavior may alleviate the negative impact of low resource levels. We tested preregistered hypotheses with 118 firefighters participating in two-week leadership courses at a German fire academy. The participants completed short web-based questionnaires before and after classes each day. Multilevel analyses confirmed that perceived daily supportive and humble instructor behavior predicted trainees’ reports of daily self-regulated learning activity. Notably, this effect was independent from positive effects of trainees’ reported energy resources in the morning. Supportive and humble behavior did not moderate the effect of energy resources. Our findings suggest that instructors play a crucial role in facilitating effective learning under challenging training conditions. Furthermore, we offer implications for leaders in fire services, who often conduct trainings with their subordinates.
How Can Malaysian Courts Consistently Perform Meaningful Constitutional Rights Review? Lessons from Past Cases and the Way Forward
Authors: Ong Benjamin Joshua
Published: May 2024

In the past, Malaysian courts performing constitutional rights review played a merely clerical role, applying a test that was trivially easy for legislation to pass. Then a more rigorous proportionality test took root. However, the Federal Court in the 2020 case of Letitia Bosman whittled the test down again, and the courts once more played a minimal role in checking state action. The reasons for this cannot be explained merely by diversity in judicial philosophy or political contextual factors. Rather, the near-demise of proportionality (and, with it, robust constitutional review) was made possible by a lack of a clear sense of the doctrinal foundations of proportionality (and, indeed, of constitutional rights review generally), and the relative roles of the courts and the legislature therein. As a result, there is a risk that the courts’ important role in safeguarding constitutional rights has been minimised to near vanishing point. This article aims, through an analysis of the case law and its foundations, to explain how this came to be, and hence highlight important issues which Malaysian constitutional law must grapple with if meaningful rights review is to take place.
Investor Obligations: Transformative and Regressive Impacts of the Business and Human Rights Framework
Authors: Van der Ploeg Klara Polackova
Published: May 2024

The business and human rights (BHR) framework has regularly been considered the superior legal regime of corporate accountability for business-related human rights abuses, which must be both protected from and incorporated into investment treaties. However, investment treaties have surpassed the BHR framework in an important respect: certain investment treaties impose strict international legal obligations, including human rights-related obligations, directly on investors, thereby going beyond the normatively ambiguous corporate responsibility to respect. Investment treaty reform initiatives, including those seeking to align investment treaties with the BHR agenda, should, therefore, take care to avoid inadvertently undoing this advance towards investors’ legal accountability.
P.011 Efficacy and safety of ravulizumab in adults with AQP4+ NMOSD: interim analysis from the ongoing phase 3 CHAMPION-NMOSD trial
Authors: Pittock SJ , Barnett M , Bennett JL , Berthele A , de Sèze J , Levy M , Nakashima I , Oreja-Guevara C , Palace J , Paul F , Pozzilli C , Mashhoon Y , Allen K , Parks B , Kim H , Vorobeychik G
Published: May 2024

Background: CHAMPION-NMOSD (NCT04201262) is an ongoing global, open-label, phase 3 study evaluating ravulizumab in AQP4+ NMOSD. Methods: Adult patients received an intravenous, weight-based loading dose of ravulizumab on day 1 and a maintenance dose on day 15 and every 8 weeks thereafter. Following a primary treatment period (PTP; up to 2.5 years), patients could enter a long-term extension (LTE). Results: 58 patients completed the PTP; 56/2 entered/completed the LTE. As of June 16, 2023, median (range) follow-up was 138.4 (11.0-183.1) weeks for ravulizumab (n=58), with 153.9 patient-years. Across the PTP and LTE, no patients had an adjudicated on-trial relapse during ravulizumab treatment. 91.4% (53/58 patients) had stable or improved Hauser Ambulation Index score. 91.4% (53/58 patients) had no clinically important worsening in Expanded Disability Status Scale score. The incidence of treatment-emergent adverse events (TEAEs) and serious adverse events was 94.8% and 25.9%, respectively. Most TEAEs were mild to moderate in severity and unrelated to ravulizumab. TEAEs leading to withdrawal from ravulizumab occurred in 1 patient. Conclusions: Ravulizumab demonstrated long-term clinical benefit in the prevention of relapses in AQP4+ NMOSD with a safety profile consistent with prior analyses.
P.035 Cardiac screening in children with genetic epilepsy at risk for sudden unexpected death in epilepsy
Authors: Ezekian J , Aschner A , Zahavich L , Hamilton R , Donner E , Bulic A
Published: May 2024

Background: People with epilepsy experience higher rates of cardiac arrhythmia and sudden death than the general population, with the highest risk in genetic epilepsies. Despite growing evidence of a possible cardiac contribution, routine cardiac screening for epilepsy patients is rarely performed. Methods: We performed a single center, retrospective review of patients with developmental epileptic encephalopathies caused by genetic variants expressed in the heart and brain. Clinical history, medications, age, and cardiac evaluation data were extracted. Results: Among 67 patients (56% female), 54 (81%) had at least one ECG. Twenty (37%) had an abnormal ECG. Forty-one had a repeat ECG: 8 showed persistent abnormalities, 7 resolution of abnormalities, and 7 a new abnormality. Five patients with an abnormality did not receive a follow up ECG. Two patients each had histories of cardiac arrest, syncope, and sudden death in a family member. Cardiac phenotypes differed in patients who experienced generalized tonic-clonic seizures and patients with epilepsy for 3+ years. Conclusions: Almost 1/3 of our high-risk epilepsy cohort had history of cardiac events or abnormalities on cardiac testing. Seizure type and epilepsy duration were associated with altered cardiac phenotypes. Since some findings were potentially clinically significant, routine cardiac screening of high-risk epilepsy patients may be warranted.
P.049 Acetazolamide use for myoclonus: case report of 2 patients with progressive myoclonic epilepsy and literature review
Authors: Teixeira Marques P , Atif A , Lira V , Zulfiqar Ali Q , Andrade D
Published: May 2024

Background: Cortical myoclonus originates at cerebral cortex, predominantly occurring on voluntary movements. Few case reports described usage of Acetazolamide (ACZ) for myoclonus. Methods: Chart review of 2 patients was performed. Literature review was conducted on myoclonus and ACZ using Pubmed. Results: 22-year-old female was diagnosed with Progressive Myoclonic Epilepsy (PME) secondary to a KCNC1 mutation. Her symptoms started at 10 years old with bilateral tonic clonic seizures (BTCS), later developing progressive ataxia and myoclonus, involving face and limbs, which worsened with stimulus and menses. Medications included Perampanel, Clonazepam and Levetiracetam, however myoclonus was still limiting. At the age of 19, ACZ 250 mg BID was started for 2 weeks around her menses. Follow up revealed significant improvement of myoclonus, resulting in better ambulation, balance and speech, sustained 2.5 years after. 67-year-old male presented BTCS at the age of 53 along with cortical myoclonus, dementia and ataxia, leading to diagnosis of PME with a mutation on IRF2BPL. Improvement of myoclonus occurred with ACZ 250 mg BID biweekly, although balance and cognition still deteriorated. Conclusions: Previous literature outlines 4 cases of action myoclonus that responded to ACZ. We believe that ACZ should be considered to treat myoclonus, especially in cases with cortical involvement and hormonal fluctuations.
P.053 Concomitant corticosteroid use in ravulizumab-treated adults with anti-AChR antibody-positive gMG: results from the CHAMPION MG open-label extension
Authors: Nicolle MW , Annane D , Meisel A , Vu T , Mantegazza R , Katsuno M , Bril V , Aguzzi R , Frick G , Howard JF
Published: May 2024

Background: Treatment of generalized myasthenia gravis (gMG) with reduced steroid dosages may minimize steroid-associated AEs. Corticosteroid dosage changes were not permitted during the 26-week, CHAMPION MG study of ravulizumab in adults with anti-acetylcholine receptor antibody-positive (AChRAb+) gMG. Participants who completed the study could receive ravulizumab in the open-label extension (OLE; NCT03920293); corticosteroid adjustments were permitted. Methods: Patients could receive intravenous ravulizumab (blind induction or bridging dose at Week 26 [OLE start] for those previously receiving placebo or ravulizumab, respectively, then 3000–3600 mg at Week 28 and every 8 weeks thereafter) for ≤4 years. Results: Among 161 patients (78 ravulizumab, 83 placebo) who entered the OLE and received ravulizumab for ≤164 weeks, 113 received oral or enteral corticosteroids during the OLE; the proportion treated with >10 mg/day corticosteroids decreased from 58% (n=66) at first OLE dose to 37% (n=42) (35 [31%] received ≤5 mg/day and 71 [63%] received ≤10 mg/day) at last reported dose. Fourteen patients (12%) discontinued corticosteroids. The mean (SD) corticosteroid dosage/patient decreased from 17.5 (11.9) mg/day at first OLE dose to 11.7 (10.9) mg/day at last assessment. Conclusions: Ravulizumab decreased corticosteroid use in patients with AChRAb+ gMG, suggesting a steroid-sparing role for ravulizumab.
P.057 Achievement of minimal symptom expression in acetylcholine receptor antibody-positive participants treated with efgartigimod in ADAPT/ADAPT+
Authors: Bril V , Muppidi S , Howard JF , Murai H , Phillips G , Qi C , Gelinas D , Brauer E , Zhao S , Vissing J ,   the ADAPT Study Group
Published: May 2024

Background: A key efficacy indicator in generalized myasthenia gravis (gMG) treatment is improvement in MG-ADL score. Minimal symptom expression (MSE, MG-ADL total score of 0 or 1) is explored as a novel proposed treatment target in gMG in the phase 3 study of intravenous efgartigimod, ADAPT, and its open-label extension, ADAPT+. Methods: Post hoc analyses of acetylcholine receptor antibody positive participants in ADAPT (n=129) and ADAPT+ (n=111) were performed. Results: In ADAPT, 44.6% receiving efgartigimod achieved MSE vs 10.9% of participants given placebo. Despite less frequent assessment during ADAPT+, 40.5% of participants achieved MSE. Eighty-one percent of participants treated with efgartigimod who achieved MSE in ADAPT also achieved MSE during ADAPT+; 23% who had not achieved MSE in ADAPT did in ADAPT+. Achieving MSE was associated with substantial improvements in QMG, MGC, MG-QoL15r, and EQ-5D-5L mean scores of 11.4, 16.0, 12.4, and 0.3 points, respectively, from baseline to best score (across all visits). These drastic improvements resulted in quality of life (QoL) comparable to that of healthy populations. MSE achievement also resulted in sustained improvements in these disease-specific and QoL measures. Conclusions: Participants who achieved MSE showed substantial and consistent improvements across multiple disease measures and experienced QoL comparable to that of healthy populations.