bluuebunny/crossref_metadata_2025 huggingface dataset:
Micro-electro-mechanically tunable optical phase matching and mode conversion
Authors: Pruessner Marcel W. , Roxworthy Brian J. , Kozak Dmitry A. , Tyndall Nathan F. , Rabinovich William S. , Stievater Todd H.
Published: December 2022

Mode-division multiplexing (MDM) enables a large increase in the information-carrying capacity of an optical network. Recently, chip-scale MDM devices that can switch different mode orders to different output waveguides have been demonstrated. However, an important milestone showing dynamically tunable mode-order conversion in a single compact device has so far not been reported. In this work, we demonstrate via simulation and measurement a new, to the best of our knowledge, approach for reconfigurable mode conversion using optical micro-electro-mechanical systems (MEMS) to locally modify the effective index in an asymmetric coupler. Modeling shows that dynamic tuning to increase or decrease the mode order is possible. Measurements on fabricated devices are consistent with simulations of reconfigurable mode conversion based on tunable phase matching. Our experimental results demonstrate reconfigurable TE0-TE2 to TE0-TE1 conversion and validate this new tunable phase-matching approach for mode-division multiplexing.
Modifying the coherence of vertical-cavity surface-emitting lasers using chaotic cavities
Authors: Alkhazragi Omar , Dong Ming , Chen Liang , Liang Dong , Ng Tien Khee , Zhang Junping , Bagci Hakan , Ooi Boon S.
Published: December 2022

Vertical-cavity surface-emitting lasers (VCSELs) have been widely
adopted in a variety of applications in recent years, with even more
applications currently under research and development as a result of
the emergence of visible-light VCSELs. Most of these applications make
use of the ease of fabrication of large two-dimensional arrays of
lasers, a feature unique to VCSELs that makes them scalable and
versatile. However, applications that rely on the uniformity of the
emitted beam in the transverse plane, such as illumination,
projection, holography, and displays, suffer from the coherence
artifacts (speckles) that reduce the quality of the formed images when
coherent lasers are used. In this work, we show that, by using a
chaotic-cavity D-shaped mesa, the coherence of broad-area VCSELs can
be substantially reduced (the number of mutually incoherent modes is
almost doubled, and the spectral full width at half-maximum is
increased from

∼

1.1

n
m

to

∼

4.5

n
m

), and the maximum achievable optical
power is increased by up to 60%. The simplicity of implementing the
reported design, which requires no additional fabrication steps, makes
it a promising solution for applications that would benefit from the
lower speckle density of the emitted light as well as those that rely
on lower temporal coherence, such as time-domain optical coherence
tomography and fiber-optic gyroscopes.
Multiscale compression-induced restructuring of stacked lipid bilayers: From buckling delamination to molecular packing
Authors: Porras-Gómez Marilyn , Kim Hyunchul , Dronadula Mohan Teja , Kambar Nurila , Metellus Christopher J. B. , Aluru Narayana R. , van der Zande Arend , Leal Cecília
Published: December 2022

Lipid membranes in nature adapt and reconfigure to changes in composition, temperature, humidity, and mechanics. For instance, the oscillating mechanical forces on lung cells and alveoli influence membrane synthesis and structure during breathing. However, despite advances in the understanding of lipid membrane phase behavior and mechanics of tissue, there is a critical knowledge gap regarding the response of lipid membranes to micromechanical forces. Most studies of lipid membrane mechanics use supported lipid bilayer systems missing the structural complexity of pulmonary lipids in alveolar membranes comprising multi-bilayer interconnected stacks. Here, we elucidate the collective response of the major component of pulmonary lipids to strain in the form of multi-bilayer stacks supported on flexible elastomer substrates. We utilize X-ray diffraction, scanning probe microscopy, confocal microscopy, and molecular dynamics simulation to show that lipid multilayered films both in gel and fluid states evolve structurally and mechanically in response to compression at multiple length scales. Specifically, compression leads to increased disorder of lipid alkyl chains comparable to the effect of cholesterol on gel phases as a direct result of the formation of nanoscale undulations in the lipid multilayers, also inducing buckling delamination and enhancing multi-bilayer alignment. We propose this cooperative short- and long-range reconfiguration of lipid multilayered films under compression constitutes a mechanism to accommodate stress and substrate topography. Our work raises fundamental insights regarding the adaptability of complex lipid membranes to mechanical stimuli. This is critical to several technologies requiring mechanically reconfigurable surfaces such as the development of electronic devices interfacing biological materials.
A quality improvement study on the relationship between intranasal povidone-iodine and anesthesia and the nasal microbiota of surgery patients
Authors: Hammond Eric N. , Kates Ashley E. , Putman-Buehler Nathan , Watson Lauren , Godfrey Jared J. , Brys Nicole , Deblois Courtney , Steinberger Andrew J. , Cox Madison S. , Skarlupka Joseph H. , Haleem Ambar , Bentz Michael L. , Suen Garret , Safdar Nasia
Published: December 2022

Introduction

The composition of the nasal microbiota in surgical patients in the context of general anesthesia and nasal povidone-iodine decolonization is unknown. The purpose of this quality improvement study was to determine: (i) if general anesthesia is associated with changes in the nasal microbiota of surgery patients and (ii) if preoperative intranasal povidone-iodine decolonization is associated with changes in the nasal microbiota of surgery patients.

Materials and methods

One hundred and fifty-one ambulatory patients presenting for surgery were enrolled in a quality improvement study by convenience sampling. Pre- and post-surgery nasal samples were collected from patients in the no intranasal decolonization group (control group, n = 54). Pre-decolonization nasal samples were collected from the preoperative intranasal povidone-iodine decolonization group (povidone-iodine group, n = 97). Intranasal povidone-iodine was administered immediately prior to surgery and continued for 20 minutes before patients proceeded for surgery. Post-nasal samples were then collected. General anesthesia was administered to both groups. DNA from the samples was extracted for 16S rRNA sequencing on an Illumina MiSeq.

Results

In the control group, there was no evidence of change in bacterial diversity between pre- and post-surgery samples. In the povidone-iodine group, nasal bacterial diversity was greater in post-surgery, relative to pre-surgery (Shannon’s Diversity Index (P = 0.038), Chao’s richness estimate (P = 0.02) and Inverse Simpson index (P = 0.027). Among all the genera, only the relative abundance of the genus Staphylococcus trended towards a decrease in patients after application (FDR adjusted P = 0.06). Abundant genera common to both povidone-iodine and control groups included Staphylococcus, Bradyrhizobium, Corynebacterium, Dolosigranulum, Lactobacillus, and Moraxella.

Conclusions

We found general anesthesia was not associated with changes in the nasal microbiota. Povidone-iodine treatment was associated with nasal microbial diversity and decreased abundance of Staphylococcus. Future studies should examine the nasal microbiota structure and function longitudinally in surgical patients receiving intranasal povidone-iodine.
Leader extraversion and team performance: A moderated mediation model
Authors: Zhang Jun , Yin Kui , Li SiQi
Published: December 2022

Extraversion is the best and most consistent predictor of important leadership outcomes. However, there has been little exploration and examination of the mechanisms underlying the effects of extraverted leadership on performance. Drawing on distal-proximal motivational theory and situational strength theory, the present study proposes and examines a moderated mediation model that explains how leader extraversion affects team performance and how situational characteristics strengthen or constrain this relationship. Respondents were recruited through management team training courses run by the eight Chinese companies. We conducted two rounds of electronic questionnaire collection. The first round of data was collected during the training session. Four weeks later, we collected the data through the training courses’ WeChat groups. Data collected from 226 Chinese team leaders was analyzed using SPSS 26 and Mplus 7. We find that leader extraversion predicts team performance through a motivational mechanism operationalized as leader work engagement. We further find that goal clarity and process clarity play an important role in strengthening the positive effect of leader extraversion on leader work engagement as well as the motivational mechanism, providing an empirical explanation of how leader extraversion affects team performance through a motivational mechanism operationalized as leader work engagement. We also explore how two potential situational characteristics, operationalized as goal clarity and process clarity of leaders, affect the relationship between leader extraversion and leader work engagement as well as the motivational mechanism. Addionally, the findings suggest important practical implications for the organizations seeking to identify effective team leaders.
Assessing the dimensionality of scores derived from the Revised Formal Thought Disorder Self-Report Scale in schizotypy
Authors: Sumner Philip J. , Meyer Denny , Carruthers Sean P. , Amirul Islam Fakir M. , Rossell Susan L.
Published: December 2022

The current work explored the dimensionality and convergent validity of responses to Barrera et al.’s (2015) 29-item Formal Thought Disorder–Self Scale (FTD-SS) obtained in two non-clinical samples. Exploratory factor analyses were conducted in Sample 1 (n = 324), yielding evidence of three correlated factors, although simple structure was not achieved until nine items were removed. Support for the correlated three factors model of responses to the revised 20-item scale (FTD-SS-R) was replicated when a confirmatory factor analysis was conducted in Sample 2 (n = 610). Finally, convergent associations were found between FTD-SS-R scores and scores from other schizotypy measures across both samples, though these measures only explained half of the variance in FTD-SS-R scores. Additional research is needed to evaluate the appropriateness of the items and incremental validity of the scale in non-clinical samples.
Development of a customized mask retainer for improving the fit performance of surgical masks
Authors: Pan Yuanyuan , Xi Qi , Meng Jiali , Chen Xi , Wu Guofeng
Published: December 2022

This study introduces a customized mask retainer to improve the fit performance of surgical masks using various advanced digital techniques. The participant’s 3D face scans with and without a surgical mask were taken by using a smartphone. The mask retainer was designed using the 3D face scan data based on the facial anthropometric landmarks. The fitting was inspected and adjusted using the masked face scan data. The retainer was fabricated using a 3D printer. The effectiveness of the retainer on the augmentation of the fit of the surgical mask was tested according to the Chinese Standard (GB 19083–2010). A questionnaire was used to assess the effect of wearing surgical masks with and without retainers and N95 respirators on subjective perception of discomfort. The effectiveness test of the retainer on the augmentation of the fit performance showed a better than 25-fold increase in the overall fit factor, meeting the fit requirement for KN95 respirators in China. The subjective perception of discomfort of wearing N95 was significantly greater than surgical mask with and without retainers. The fit factor results indicated that by using the retainer, the overall fit factors and that of each exercise significantly increased compared to that of the group with the surgical mask alone. And compared with N95, the surgical mask with the retainer significant improved comfort. The surgical mask with the retainer can provide an alternative of personal protective equipment for healthcare workers.
Rib fractures in the Coimbra Identified Skeletal Collection
Authors: Curate Francisco , Cunha Eugénia
Published: December 2022

There is a high prevalence of rib fractures in human remains from archeological contexts, but these are seldom the focus in paleopathological studies pertaining skeletal trauma. This study aims to document rib fracture patterns in the Coimbra Identified Skeletal Collection, Department of Life Sciences, University of Coimbra. Specific aims of this study included the estimation of rib fracture prevalence in 252 individuals, from both sexes (females: 128; males: 124), with age-at-death varying from 20 to 96 years; and the analysis of the relationship between rib fractures and age-at-death, biological sex, and bone mineral density measured at the proximal femur. The crude prevalence of rib fractures is 6.3% (16 cases in a total of 252 individuals observed); while the true prevalence rate is 0.7% (38 fractured ribs in relation to 5656 ribs studied). Males have been more affected than females (males: 10.5%, 13/124; females: 2.3%, 3/128). Individuals with one or more rib fractures were significantly older (mean=66.19 years old; standard deviation [SD]=14.08) than those who have not experienced any rib fracture (mean=50.41 years old; SD=19.45). Bone mineral density was also associated with the presence of rib fractures but only in females. These results expand the scientific awareness about the prevalence of rib fractures in human skeletal collections.
Para além das erratas
Authors: De Amorim Rosas Juliana
Published: December 2022

Este artigo apresenta análise sobre a crítica jornalística produzida pelo ombudsman de imprensa e sua relação com a democracia. Foi investigada a crítica jornalística brasileira em colunas de ombudsman em dois períodos distintos – 1995 e 2019, em jornais considerados referenciais em escala regional e nacional: Correio da Paraíba, Folha de S. Paulo e O Povo. Como método de investigação, foi utilizada a Análise de Conteúdo delineada por Laurence Bardin (2011), auxiliada pelo software Iramuteq. A base teórica incluiu a Teoria da Crítica de Imprensa (Wyatt, 2007) e os modelos de democracia e suas implicações normativas para o jornalismo traçados por Jesper Strömbäck (2005). Entre outras características apresentadas, conclui-se que, preponderantemente, veículos noticiosos e ombudsmans possuem visão distinta de modelos democráticos no jornalismo e poucas vezes a crítica alcança o ideal deliberativo proposto pela teoria utilizada.
COVID-19 and Hip Osteoarthritis Disability-Linkages and Emerging Practice Implications
Authors: Marks Ray
Published: December 2022

Older adults suffering from chronically painful disabling osteoarthritis of one or more joints such as the hip joint continue to experience multiple health issues, commonly progressive debility, and excess disability. This mini review strove to examine current perspectives in the realm of hip joint osteoarthritis, a widespread disabling disease affecting many older adults in the face of the possible repercussions of the multiple COVID-19 restrictions in response to the SARS-CoV-2 pandemic that emerged in late 2019, along with the persistence of multiple evolving COVID-19 variants that remain lethal to many older adults, especially among the older chronically impaired population. Using multiple data bases, results reveal that very little progress has been made in recent times to mitigate hip osteoarthritis, along with very few innovative treatment approaches when severe, other than surgery and medication. Moreover, a multitude of non-pharmacologic approaches have not reduced numbers of cases requiring surgery to any extent, even when employed. In addition, outcomes of hip joint replacement surgery, and other treatments for ameliorating unrelenting pain remain largely suboptimal, especially where those undergoing surgery may now be more impaired than in pre pandemic times, and where high rates of opioid related deaths prevail in this regard. As such, it is concluded that whether in the community or being treated in hospital, exposure to COVID-19 remains risky especially in cases who are now weaker and frail, plus suffering from excess chronic disease manifestations, thus warranting more attention and protection of this high risk group, plus insightful preventive efforts to avert multiple interacting COVID-19 effects in the realm of osteoarthritis suffering, especially where patients are willing to risk infection by undergoing surgery.
Comparison the Diagnostic Value of Doppler Ultrasonography to Biopsy, in Evaluation of Post-transplant Complications and Kidney Function
Authors: Salmanipour Alireza , Ghadamzadeh Mostafa , Morteza Bagheri Seyed , Hajipour Roja , Sadeghi Pedram , Vahedifard Farzan
Published: December 2022

Background Doppler ultrasonography can evaluate vascular and renal parenchymal disorders. In this study, color Doppler patterns in transplanted kidneys were compared with histological diagnosis to develop diagnostic models for transplanted kidney failure. Method 45 kidney transplant patients participated in this prospective study (16 suffered acute tubular necrosis (ATN), and 29 had transplant rejection). All patients had color-Doppler ultrasonography to measure kidney parameters and Doppler indices. Serum creatinine levels also assessed the transplanted kidney's function. Result Ultrasound showed a significant difference between the two groups in iliac and interlobar PSV. The ROC analysis showed a high diagnostic value of the iliac artery PSV, in distinguishing ATN from kidney transplant rejection. Serum creatinine level correlated directly with transplanted kidney volume, renal cortical thickness, and transplanted kidney length, and inversely with interlobar artery PSV and EDV. In graft rejection patients, the only significant inverse correlation was found between serum creatinine level and PSV of the iliac artery and EDV of the intrelobar artery. Discussion and conclusion The iliac artery PSV can differentiate between ATN and rejection after renal transplantation. Evaluation of renal metric parameters along with PSV and EDV of the interlobar artery (in patients with ATN) and iliac artery and interlobar artery (in transplant rejection) help determine renal dysfunction.
Quality of Maternal & Newborns Health indicators in Western Province of Rwanda
Authors: Rutayisire Erigene , Niyonkuru Mathieu
Published: December 2022

Data quality is defined as a measure of data status that fulfills the following elements: accuracy, completeness, consistency, reliability, and if the data is current. The World Health Organization (WHO) reported that only 40% of all countries have an adequate system to collect information on birth and deaths. Even though the system is there, vital registration systems are inaccurate and incomplete in developing countries. In Rwanda, maternal health related data was over-reported more than other indicators. These are the main reasons for conducting the study to investigate the data quality of four maternal and newborn health indicators reported by Rwandan Western Province health centers. This concurrent-mixed method study included 61 data managers and 12 key informants. Routine data quality assessment tool and structured interview guide were used to collect data. Descriptive statistics were used to get proportion of respondents’ socio-demographic characteristics. The analysis was done for assessing median of data quality index. The results show that 55.7% of data managers were male while 58.3% of responsible of maternity were female. Majority (58.9%) of participants was in age’s category from 33-42, 61.6% have A1 education level and 53.4% have experience less than five years. Data quality index of one out of four (25%) MNH indicators was found below 95% accepted by WHO. The main reasons for insufiscient quality of data are lack of data validation meetings (57.5%) and incompleteness of reporting tools (36.4%). Monthly data validation meetings chaired by HC leaders are important to contribute to high-quality data in healthcare settings. Supportive supervisions done in data quality and management have to be organized in a supportive, and educative way.
The Computer Crimes of Vasiliy Gorshkov and Alexey Ivanov
Authors: L. Buresh, Ph.D., JD, LL.M Donald
Published: December 2022

The purpose of this essay was to document the cybercrimes of Vasiliy Gorshkov and Alexey Ivanov, starting from their humble beginnings in Chelyabinsk, Russia to their convictions for conspiracy, violations of the Computer Fraud and Abuse Act, and other federal crimes. The paper outlines the history of these two individuals, describing the circumstances under which they were arrested and prosecuted. The essay concludes by observing that the mainstream media characterized Gorshkov and Ivanov as villainous Russian hackers, whereas in reality, they were would-be Russian entrepreneurs attempting to earn their fortune by illicit means.
Escuelas coherentes: validez de contenido de una rúbrica para evaluar centros desde la visión del profesorado
Authors: Rodríguez Olay Lucía , Muñoz San Roque Isabel , Santaolalla Pascual Elsa , Martín Carrasquilla Olga , Soria Martínez Arántzazu
Published: December 2022

El presente artículo tiene como objetivo analizar la validez de contenido de un instrumento formato rúbrica para ser cumplimentado por docentes para medir los indicadores de funcionamiento fundamentales en los centros educativos siguiendo el enfoque de escuelas coherentes. Durante el proceso de diseño y validación de contenido del instrumento, se ha constatado la complejidad de un concepto que abarca múltiples dimensiones, no solo del centro educativo, sino de toda la configuración de la comunidad escolar. Esto ha supuesto que se hayan puesto de relevancia las relaciones entre los diversos elementos que configuran una escuela y, de este modo, se han determinado, también, las conexiones existentes entre los aspectos académicos, socioeconómicos y personales que interactúan entre sí. Los resultados de la evaluación del instrumento creado muestran que deben reducirse algunas de las cuestiones planteadas bien por no resultar relevantes o bien por falta de claridad de las mismas. El instrumento puede ser útil para que, aquellos centros con interés por medir diversos estándares que puedan redundar en su mejora y determinar su grado de coherencia, puedan aplicarla y obtener resultados que contribuyan a determinar sus futuras líneas estratégicas.
La COVID-19 impulsa las nuevas tecnologías en el aula universitaria
Authors: Aznar Sala Francisco Javier
Published: December 2022

En el curso 2019/20 se suspendieron las clases en todos los niveles educativos con el reajuste del modelo formativo debido a la COVID-19. El profesorado tuvo que hacer un esfuerzo para adquirir nuevas destrezas en una educación que demandaba nuevos modelos inspirados en la competencia digital. El objetivo principal de este trabajo se centra en conocer el grado de satisfacción del alumnado en este modelo a distancia. Se ha desarrollado dentro de la Facultad de Ciencias de la Educación de una universidad privada de la ciudad de Valencia. En la investigación han participado 222 alumnos que cursan el Grado de Educación Primaria a través de un método cuantitativo diseñado online con cinco ítems trazados para tal fin. El análisis de datos se ha realizado con el programa SPSS/PC versión 20.0. Los resultados señalan que el alumnado está plenamente preparado para albergar un tipo de educación remota en ambos sexos.
Soloviev: arte, materia y espíritu
Authors: García-Lomas Gago Luis Javier
Published: December 2022

A partir de la publicación en español de los textos sobre estética de V. Soloviev y de las primeras investigaciones sobre su pensamiento en relación con el arte, este artículo pretende identificar los conceptos clave que constituyen esta estética, subrayando los presupuestos antropológicos y epistemológicos que comportan. Al mismo tiempo, se contrasta el pensamiento de Soloviev con algunos pensadores posteriores, singularmente con V. Kandinsky, cuya concepción de lo espiritual en el arte, a pesar de sus diferencias, puede dialogar con el pensamiento de Soloviev.
Aspectos filosóficos de la música en la antigua Grecia
Authors: Forcillo María Fernanda
Published: December 2022

El propósito de este artículo es demostrar la relevancia de la música en la filosofía clásica griega. Los griegos la consideraban como reguladora de las emociones de los ciudadanos y generadora valores éticos, siendo, por tanto, un instrumento indispensable para el logro de una convivencia pacífica en la polis. Este trabajo, parte de los principios establecidos por Pitágoras en la Música de las Esferas y la relación armónica existente entre las matemáticas y la música y la posterior influencia de esta doctrina sobre el pensamiento de Platón y Aristóteles sobre del poder de la música para hacer del ciudadano un ser virtuoso. Como conclusión, se efectúa un paralelismo entre estas concepciones y los últimos descubrimientos neurocientíficos sobre la importancia de le emoción en la ética.
Reliability Analysis of Radiation Tolerant Low Voltage CCCII Circuit For Space Applications
Authors: Pathak Aruna , Tiwari Manoj Kumar , Pandey Neeta , Paul Sajal K , Rizvi Saiyid Mohammad Irshad
Published: December 2022

In this paper, the impact of radiation on the MOS devices is investigated on recently reported programmablesecond generation Current Controlled Conveyor (CCCII) wherein some updates are suggested to take Hot Carrier Injection, Bias Temperature Instability, and Time Dependent Dielectric Breakdown into account. As radiation is yet another important factor that causes change in threshold voltage, the transistors which are amenable to larger threshold shift and may lead to functional failure are identified first. Subsequently, three possibilities; uses of all thin oxide devices, all thick oxide devices, and mixed devices are being investigate and it is found that while using mixed devices, the circuit becomes functional at lower voltage without any effective increase in leakage current. Architecture is updated to enhance the performance of circuits under time-based ageing and radiation environment. The major challenge is to control dynamic leakage and radiative noise due to imposed radiation. All simulations are carried out using 28nm CMOS technology models in Cadence Virtuoso environment using ±1.0V supply voltage and results have been verified with post layout netlist. Proposed circuit can function at low voltage with the reduced degradation for 8 years at 25 °C consumes less area as compared to the existing CCCII circuit with 0.008 FIT value.
Effect of Aviation Turbine Fuel Exposure on Interlaminar and Inplane Shear Properties of Glass Fiber Reinforced Epoxy Composite
Authors: Shrivastava S.M. , Ramarao G , Buragohain Manoj Kumar , Selvaraj N
Published: December 2022

This study investigated the effect of aviation turbine fuel exposure on interlaminar and in-plane shear properties of E-glass/epoxy composite. The two types of test specimens, namely bare and resin-coated specimens with varying thicknesses as per the ASTM standard, were made out of E-glass/epoxy composite to evaluate their interlaminar and in-plane shear properties. These all types of specimens were immersed inside the aviation turbine fuel for two months and then afterward their effect on the reduction of mechanical properties like interlaminar and in-plane shear tests properties were experimentally investigated. Test results show that ATF fuel exposure has reduced the interlaminar shear strength by 10.04 %, 7.83 %, and 6.01 % for bare, with 0.1 mm and 0.2 mm resin coating, respectively. Similarly, in-plane shear strength was reduced by 14.75 %, 11.22 %, and 7.52 % for bare, with 0.1 mm and 0.2 mm resin coating, respectively, and in-plane shear modulus was reduced by 10.87 %, 8.94 %, and 6.52 % for bare, with 0.1 mm and 0.2 mm resin coating conditions as compared to as-received (without ATF exposure) specimens.SEM micrographs and results too showed that properties were reduced and indicated that the glass/epoxycomposite was resistive to fuel ingression. It was observed that bare specimens exhibited a reduction in shearproperties due to ATF ingression to the polymeric network and induced internal stresses, which not only degraded the matrix and fiber-matrix adherence but created micro-cracks too in the resin at interfaces. Resin-coated specimens limit fuel ingression, which has led to a reduction in properties.
A DIFERENÇA COMO VALOR NA OBRA LITERÁRIA DE LUÍSA DUCLA SOARES
Authors: Guerreiro Carla
Published: December 2022

Pretendemos celebrar o cinquentenário da obra literária de potencial receção infantojuvenil da autora portuguesa Luísa Ducla Soares, revisitando um corpus textual representativo da sua escrita, constituído pelas obras: O soldado João (1973), Gente Gira (2002), Tudo ao contrário (2002) e Seis histórias às avessas (2003), no âmbito do reconhecimento e respeito pela Diferença como valor que lhes está subjacente. Esta escritora integra o corpus textual de leitura recomendada e obrigatória da Educação Literária nos 1.º e 2.º Ciclos do Ensino Básico e é referenciada no Plano Nacional de Leitura. Além do mais é também uma autora por nós trabalhada na unidade curricular de literatura infantojuvenil, que integra o currículo do curso de licenciatura em Educação Básica e em literatura para a infância, unidade curricular do 1.º ano de mestrado do 2.º Ciclo de estudos dos cursos de Educação Básica. Pelo exposto, com base em revisão e análise textual do corpus textual supracitado, consideramos que a literatura de potencial receção infantojuvenil desta autora promove uma educação inclusiva e de respeito pela diferença que deve ser conhecida e trabalhada em contexto escolar.
MENAKAR EFEKTIVITAS KONSEP OMNIBUS LAW DALAM UNDANG-UNDANG NOMOR 11 TAHUN 2020 TENTANG CIPTA KERJA DI MASA PANDEMI COVID-19
Authors: Yusliwidaka Arnanda
Published: December 2022

Konsep omnibus law dalam UU Cipta Kerja merupakan suatu terobosan besar dalam penataan hukum di Indonesia. Konsep tersebut melakukan penataan agar tidak terjadi tumpang tindih dari banyaknya regulasi-regulasi yang saling terkait. Pandemi Covid-19 memberikan dampak terhadap aspek ekonomi yang mengharuskan negara-negara melakukan resesi dan melakukan respon cepat agar tidak mengalami keterpurukan dalam sektor perekonomian. Indonesia melakukan respon dampak Pandemi Covid-19 dalam aspek ekonomi tersebut salah satunya dengan mengesahkan UU Cipta Kerja dengan harapan bahwa langkah ini dapat meningkatkan sektor perekonomian negara. Usaha tersebut tidak berjalan dengan baik, terdapat pro dan kontra dari beberapa kalangan masyarakat terhadap UU Cipta Kerja. Oleh karena adanya pro dan kontra yang begitu masif di kalangan masyarakat, diperlukan adanya suatu kajian untuk mengukur tingkat efektivitas konsep omnibus law dalam pembentukan UU Cipta Kerja untuk memunculkan suatu sudut pandang yang objektif dalam menilai urgensi dibentuknya undang-undang tersebut.
Unlocking the game within the child: a youth sport pedagogy model from the U.S.
Authors: Quinn Ronald W.
Published: December 2022

The positive and appropriate development of children through youth sport is of the utmost importance. The quality of this experience can also have a direct effect on their life-long engagement in physical activity and sport (Newman et al., 2018). The Game in the Child Model was designed on the premise that you must first learn how to teach the child before you can teach them to play the sport and is most beneficial for children 12 years of age and younger. This foundational premise guides all other components of the model from a philosophical as well as a developmental level. These guiding factors consist of four levels beginning with child characteristics (how they think, feel, grow), coach characteristics (their past and present experiences), organizational characteristics (type and purpose). The leads to gaining a better understanding of how play can be used as a tool for growth and development within an athlete-centered environment. The final two levels address a game-based pedagogical approach that reflects the first two levels with the goal of unlocking the Game within the Child. The model also recognizes the importance of the child’s social, economic, and political influences through the envelopment of Bronfenbrenner’s Ecological Theory (1975, 1977).
Gambling among university sport students: a preliminary analysis
Authors: Jones Carwyn Rh. , Bowles Harry C. R. , Mayes Daisie , Smith Heidi
Published: December 2022

The aim of this study was to explore risks associated with the gambling habits and attitudes of sport students governed by betting integrity rules. Using focus groups with male and female student rugby and football players, we identified four areas of concern. First, participants considered gambling as a ‘normal’ pastime – a largely harmless form of communal entertainment. Second, we found that participants’ gambling behaviour was influenced by marketing strategies and by peers. Third, although participants were aware of some of the potential risks of gambling, they had a limited understanding of how problem gambling and addiction might develop. Taken together, we believe these encourage gambling and increase risks of gambling related problems. The fourth concern relates to breaking integrity rules. Although we found no evidence of intentional corrupt behaviour, participants had a casual attitude towards gambling regulations, and some broke the betting rules in ways they deemed trivial. Moreover, participants did not seem to take anti-corruption education/intervention particularly seriously.
Effect of physical activities and sport among patients with asthma on their life
Authors: Sýkorová Kamila
Published: December 2022

Objectives: The aim of this study was to analyse active level of lifestyle among asthmatic patients and their participation on physical activities and sports. Another goal was to find out whether asthmatic patients are limited when performing physical activities or sports because of the medical condition and how physically active lifestyle influences the medical condition and whether it takes part on improving their quality of life.
Methods: A survey was used for data collection. To gather information, our own survey form was developed – a self-reported tool which clinically compares and measures physical activity (such as other standardised and international forms: International Physical Activity Questionnaire and St. George’s Respiratory Questionnaire). A questionnaire was distributed to people working with asthmatic patients, to different sports clubs and among university students. The research group consists of 125 respondents. The obtained data was processed into tables and charts via Microsoft Office Word 2016, Microsoft Office Excel 2016 and SPSS program. A verification of hypotheses was carried out according to the results of the survey and the independence test - chi-squared test.
Results: According to the chosen data processing methods, the limitation of asthmatic patients in physical activities or sports was not confirmed – physical activities on regular basis perform 100 respondents (80%), 69 respondents (55.2%) stated no limitation within physical activities due to asthma and e.g., in patients with most severe asthma were 66.7% (n = 4) of them without limitation when being active. The positive effect of regular physical activity on reducing clinical manifestations of the asthma, on reducing medication doses and also on improving the quality of life of patients has been confirmed. Physical therapy has proven to be effective, but more emphasis is needed on educating asthmatics by healthcare professionals about this treatment method.
”Som om det aldri har skjedd”
Authors: Ottesen Siri Hovda , Tysvær Aasfrid
Published: December 2022

“As if it never happened”: Fictional Work with Forgiveness as a Value amongst 5th–7th Graders

This article examines how middle school pupils respond to an aesthetic approach to forgiveness as a value. We observed a group of pupils aged 10–12 while they were investigating and discussing Stian Hole’s picturebook Garmanns gate (Garmann’s Street, 2008) together with their teacher. We claim that Garmanns gate can be read as a story about forgiveness, and that it is also a picturebook that invites the reader to take a performative, aesthetic position; the reader is encouraged to pay attention to how the story is told as well as to the story itself (Ørjasæter, “Terskelposisjonen”). The focus of the article is to what extent investigating Garmanns gate will shed light on forgiveness, a value which is central in the Norwegian school’s purpose clause. We analysed their comments in the light of a definition that identifies different aspects of the concept of forgiveness. Our theoretical framework is Martha Nussbaum’s theory on the importance of narrative imagination in taking other peoples’ perspectives, and Louise Rosenblatt’s theory on aesthetic and efferent reading. We also refer to Maria Nikolajeva’s views on how the picturebook can promote emotional literacy. To deal with the concept of forgiveness, we use Paul Leer-Salvesen’s definition, which enables us to look at different aspects of the concept. These aspects together with “the emancipating consequences of forgiveness” are the categories we use in analysing our findings (Leer-Salvesen, Min skyld 96). We find that an aesthetic approach to Garmanns gate may provide an opportunity for a broader understanding of forgiveness, and we find that the teacher’s role is essential in guiding the pupils in the common aesthetic approach to the book, and in bringing forth reflections in the conversations.
Introduction: Who Are Residual Claimants on a Company’s Net Assets?
Authors: Fukui Yoshitaka
Published: December 2022

Two papers on the nature of equity and its implication for accounting and public policy are introduced.
Small-molecule metabolites in SARS-CoV-2 treatment: a comprehensive review
Authors: Alipoor Reza , Ranjbar Reza
Published: December 2022

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has quickly spread all over the world. In this respect, traditional medicinal chemistry, repurposing, and computational approaches have been exploited to develop novel medicines for treating this condition. The effectiveness of chemicals and testing methods in the identification of new promising therapies, and the extent of preparedness for future pandemics, have been further highly advantaged by recent breakthroughs in introducing noble small compounds for clinical testing purposes. Currently, numerous studies are developing small-molecule (SM) therapeutic products for inhibiting SARS-CoV-2 infection and replication, as well as managing the disease-related outcomes. Transmembrane serine protease (TMPRSS2)-inhibiting medicinal products can thus prevent the entry of the SARS-CoV-2 into the cells, and constrain its spreading along with the morbidity and mortality due to the coronavirus disease 2019 (COVID-19), particularly when co-administered with inhibitors such as chloroquine (CQ) and dihydroorotate dehydrogenase (DHODH). The present review demonstrates that the clinical-stage therapeutic agents, targeting additional viral proteins, might improve the effectiveness of COVID-19 treatment if applied as an adjuvant therapy side-by-side with RNA-dependent RNA polymerase (RdRp) inhibitors.
Freikirchen in Hand- und Lehrbüchern der Konfessionskunde
Authors: Triebel Lothar
Published: December 2022

Hand- und Lehrbücher der Konfessionskunde gelten im allgemeinen als probates Mittel, um sich einen Überblick über andere Kirchen zu verschaffen. In diesem Beitrag wird an den Beispielen „Pfingstbewegungen“ und „Altlutheraner“ untersucht, was ausgewählte neuere Exemplare dieser Literaturgattung in Bezug auf Freikirchen leisten. Zuvor wird grundsätzlich erörtert, wie konfessionskundliche Darstellungen methodisch sachgemäß sein können.
lncRNA ZFAS1 promotes intervertebral disc degeneration by upregulating AAK1
Authors: Wang Zheng , Liu Bin , Ma Xiangyu , Wang Yu , Han Wenfeng , Xiang Liangbi
Published: December 2022

We investigated the function of lncRNA zinc finger antisense 1 (ZFAS1) in intervertebral disc degeneration (IDD) progression in vitro and in vivo. Nucleus pulposus (NP) tissues were obtained from 20 patients with IDD. IL-1β was used to stimulate primary NP cells to establish the IDD models in vitro. Gene expression was determined by RT-qPCR. 5-Ethynyl-2′-deoxyuridine and flow cytometry were performed to determine cell proliferation and apoptosis, and western blotting was conducted to measure the apoptosis- and extracellular matrix (ECM)-related protein expression. Luciferase reporter assay was used to examine the interactions between the genes. We also investigated the effect of ZFAS1 in a mouse model of IDD induced by needle punctures. Our results showed that ZFAS1 expression was elevated in degenerative NP tissues and IL-1β-treated NP cells. ZFAS1 knockdown inhibited NP cell apoptosis and ECM degradation induced by IL-1β. Mechanically, ZFAS1 sponged miR-4711-5p and adaptor-associated kinase 1 (AAK1) was targeted by miR-4711-5p. Furthermore, AAK1 overexpression partially eliminated the impact of ZFAS1 depletion on NP cell proliferation, apoptosis, and ECM degradation. More importantly, the results of the in vivo studies confirmed the effect of silencing ZFAS1 on alleviating the symptoms of IDD mice. Overall, silencing ZFAS1 inhibits IDD progression by reducing NP cell apoptosis and ECM degradation through the miR-4711-5p/AAK1 axis.
lncRNA ELFN1-AS1 enhances the progression of colon cancer by targeting miR-4270 to upregulate AURKB
Authors: Peng Shuangqin , Luo Yanjun , Chen Lijuan , Dai Kang , Wang Qin
Published: December 2022

The oncogenic role of lncRNA ELFN1-AS1 has been described in different cancers, including colon cancer (CC). However, how ELFN1-AS1 regulates CC malignancy remains unclear. In this study, ELFN1-AS1, AURKB, and miR-4270 expression levels in CC cells and tissues were determined using RT-qPCR and western blotting. CCK-8 and wound healing assays were also performed to analyze alterations in CC cell proliferation and migration. The expression of apoptosis-related proteins (Bax and Bcl-2) was determined via western blot analysis. RNA immunoprecipitation (RIP) assays coupled with luciferase reporter assays were employed to verify the relationship between miR-4270, ELFN1-AS1, and AURKB. An in vivo assay was performed using xenograft tumors in mice to detect the change of tumor growth. It was found that AURKB and ELFN1-AS1 expression was upregulated, whereas miR-4270 was downregulated in CC cells and tissues. ELFN1-AS1 silencing exhibited anti-proliferative, anti-migratory, and pro-apoptotic effects in CC cells. The tumor-suppressive effect of ELFN1-AS1 silencing was verified using in vivo assays. MiR-4270 was predicted to be a target of ELFN1-AS1 and AURKB as a target of miR-4270. Their interactions were further elucidated using luciferase reporter and RNA RIP assays. More importantly, treatment with a miR-4270 inhibitor not only rescued the tumor-suppressing effect of ELFN1-AS1 silencing but also abrogated the tumor suppressor functions of AURKB silencing in CC cells. Taken together, the ELFN1-AS1/miR-4270/AURKB axis facilitates CC tumorigenesis; therefore, targeting this axis might be a promising intervention in preventing CC progression.
Integrated bioinformatics analysis shows integrin alpha 3 is a prognostic biomarker for pancreatic cancer
Authors: Hu Fangfang , Zhao Liangtao , Wang Yang , Ye Hao , Tang Haodong , Zhou Jiahua
Published: December 2022

Integrin subunit alpha 3 (ITGA3) expression correlates with the development and prognosis of human cancers. This study aimed to investigate the association of ITGA3 expression with pancreatic cancer (PCa) prognosis. The ITGA3 gene expression data were extracted from The Cancer Genome Atlas (TCGA) pancreatic adenocarcinoma (PAAD) cohort and 14 Gene Expression Omnibus microarray datasets. The differences in ITGA3 expression levels between tumor and non-tumor tissues were compared using the Mann–Whitney U test. Cox regression analysis and meta-analysis were performed to detect the association of ITGA3 expression with PCa prognosis. ITGA3 expression was higher in tumors than in controls. Tumors with advanced grades (3/4) had higher ITGA3 levels compared with early-grade tumors (1/2). The meta-analysis of the TCGA PAAD cohort and seven microarray datasets (GSE28735, GSE62452, GSE79668, GSE71729, GSE57495, GSE78229, and GSE21501) showed that ITGA3 was a prognostic biomarker in PCa (hazard ratio (HR) = 1.38, 95% confidence interval (CI) 1.26–1.51, p < 0.00001). Five ITGA3-related genes, including ITGB1 (HR = 1.6), ITGB5 (HR = 1.6), ITGB6 (HR = 1.6), LAMA3 (HR = 2.1), and CD9 (HR = 2.3), correlated with PCa prognosis significantly (p < 0.05). Functional enrichment analysis showed that ITGA3 was related to “hsa04151: PI3K-Akt signaling pathway” and “hsa04510: Focal adhesion.” We concluded that high ITGA3 expression was a potential prognostic biomarker in PCa.
Comparative simulations study of radiations shielding properties of 69P2O5–10Gd2O3/10GdF3–10BaO–10ZnO–1Er2O3 glasses
Authors: Sanaullah  , Dinar Falak , Khadija  , Khattak Shaukat Ali , Shoib Muhammad , Ullah Irfan , Rooh Gul , Wabaidur Saikh Mohammad , Islam Muhammad Ataul , Zulfiqar Syed , Khan Gulzar , Khan Tahirzeb
Published: December 2022

We study the theoretical and simulated shielding properties of 69P2O5–10Gd2O3–10BaO–10ZnO–1Er2O3 and 69P2O5–10GdF3–10BaO–10ZnO-1Er2O3 glasses. We exploit advanced simulation (MCNPX) and Phy-X, an online Photon Shielding and Dosimetry software, in the 0.001–15 MeV energy range, to calculate the linear attenuation coefficient and mass attenuation coefficients of the samples. The obtained mass attenuation coefficient is then used to calculate the critical radiation shielding characteristics, such as the half-value layer, mean free path, tenth value layer, and effective atomic number. The calculated LAC values range from 108.759 to 0.097 and from 84.124 to 0.087 cm−1 while HVL values range from 0.006 to 7.164 and from 0.008 to 8.013 cm, and MFP values vary from 0.009 to 10.335 and from 0.012 to 11.561 cm for ZBaOEr and ZBaFEr, respectively, with energy ranging from 0.015 to 15 MeV. We find that the results obtained from MCNPX and Phy-X are consistent with each other, based on the computed relative difference. The glass sample containing Gd2O3 exhibits better shielding properties than the one with GdF3, over the entire energy range. Our examined glass samples are thick enough to substantially lessen the intensity of incident X-rays and gamma rays.
Aspetti testuali e problemi linguistici (di datazione e localizzazione) dell’antica lingua del cibo
Authors: Pregnolato Simone
Published: December 2022

The paper focuses on some methodological, philological and linguistic problems related to the study of the most ancient culinary texts (cookbooks and practical documents) in Italian vernacular (14th century). The most relevant problems relate to the precise dating and localization of the manuscripts. These preliminary aspects are essential in order to achieve the Atlante della lingua e dei testi della cultura gastronomica italiana dall’età medievale all’Unità which can assist in identifying the origins and history of culinary language in the history of Italian.
La cucina delle parole
Authors: Alba Monica
Published: December 2022

The Glossario Artusiano (Artusian Glossary) has been designed as a lexicographical tool, capable of gathering and studying the whole lexicographical wealth of Pellegrino Artusi’s La Scienza in cucina e l’Arte di mangiar bene (1st edition in 1891; 15th edition in 1911), a cornerstone of Italian gastronomic culture. By looking at some case studies, this article illustrates the criteria, tools and methodology which may have been used to compose the glossary. The purpose is to highlight how these results can establish a constructive dialogue with the Vocabolario Storico della Lingua Italiana della Gastronomia (VoSLIG), within the framework of the AtLiTeG Project.