bluuebunny/crossref_metadata_2025 huggingface dataset:
Extraction and Analysis of Influencing Factors of Scientific and Technological Ability Improvement of University Teachers Based on Deep Learning Model
Authors: Wang Aiqin , Yan Wei
Published: September 2022

In order to improve the development and construction level of colleges and universities and help teachers improve their scientific and technological abilities, a model based on deep learning model for the extraction and analysis of factors affecting the improvement of college teachers’ scientific and technological abilities was proposed. This article analyzes the data of teaching evaluation and finds that the text contains students’ subjective understanding of teachers’ teaching quality defects. By extracting key words from students’ teaching evaluation texts and combining with the teaching evaluation indexes, a teaching evaluation label system integrating teaching evaluation texts is designed. In order to find the defects of teachers’ teaching ability, this article, based on the principle of data portrait, combines the characteristics of teachers’ personal basic information, curriculum information, teaching evaluation information, and social relations to portrait teachers. The experimental results show that the F1 value extracted from the evaluation labels fluctuates in the evaluation text data of different colleges, with the lowest value of 91.7% in the School of Statistics and the highest value of 95.8% in the School of Foreign Languages. The algorithm in this article has a higher F1 value of the evaluation label vector extracted from the evaluation text of different grades. F1 values showed a trend of gradient decline with the increase of grade, and the decreasing range became bigger and bigger. Conclusion. The constructed teacher portraits are more accurate and effective, and provide a comprehensive and effective data model for teaching ability improvement method recommendation strategy.
MTEDS: Multivariant Time Series-Based Encoder-Decoder System for Anomaly Detection
Authors: Reyana A. , Kautish Sandeep , Yahia I. S. , Mohamed Ali Wagdy
Published: September 2022

Intrusion detection systems examine the computer or network for potential security vulnerabilities. Time series data is real-valued. The nature of the data influences the type of anomaly detection. As a result, network anomalies are operations that deviate from the norm. These anomalies can cause a wide range of device malfunctions, overloads, and network intrusions. As a result of this, the network’s normal operation and services will be disrupted. The paper proposes a new multi-variant time series-based encoder-decoder system for dealing with anomalies in time series data with multiple variables. As a result, to update network weights via backpropagation, a radical loss function is defined. Anomaly scores are used to evaluate performance. The anomaly score, according to the findings, is more stable and traceable, with fewer false positives and negatives. The proposed system’s efficiency is compared to three existing approaches: Multiscaling Convolutional Recurrent Encoder-Decoder, Autoregressive Moving Average, and Long Short Term Medium-Encoder-Decoder. The results show that the proposed technique has the highest precision of 1 for a noise level of 0.2. Thus, it demonstrates greater precision for noise factors of 0.25, 0.3, 0.35, and 0.4, and its effectiveness.
Web-Cloud Collaborative Mobile Online 3D Rendering System
Authors: Liu Chang , Song Huilin , Fang Ting , Ou Qiaofeng , Yu Geng , You Tao , Ying Ming
Published: September 2022

The collaborative online 3D rendering system proposed in this paper ensures the quality of user experience and protects online rendering resources. In this system, the conditional generative adversarial network is used to calculate complex global illumination information instead of rendering them on cloud servers. The web front-end generates high-frequency direct lighting information in real-time and displays the final result which is a blend of front-end direct lighting information and back-end indirect lighting information. Experiments show that our proposed system can improve the rendering quality of the Web3D front-end, ensure Web-Cloud load balance, and protect rendering resources online.
Management of Patients with Cervicofacial Edema and Paresthesia during Perioperative Period of Transoral Endoscopic Thyroidectomy
Authors: Yang Xia , Zhao Jian Guo , Liu Mengting , Wang Shan , Wang Li
Published: September 2022

Objective. To analyze the clinical intervention effect of transoral endoscopic thyroidectomy on the neck and face during perioperative period. Method. From January 2019 to January 2020, 60 patients included in this study were randomly divided into observation group and control group according to the ratio of 1 : 1, with 30 cases in each group. Both groups underwent rapid surgical intervention during the perioperative period. The patients in the observation group received neck and face management. The degree of jaw swelling, the degree of facial microexpression completion, and the changes in jaw and neck sensation were compared between the two groups. Results. There was no significant difference in neck and face swelling, pain, facial microexpression, and feeling between the two groups before operation. Patients with facial I/II swelling degree in the observation group were significantly more than in the control group, and the patients with III swelling degree were less than in the control group. There was significant difference for facial swelling between the two groups in the three intervention periods after the operation, and the difference was statistically significant (

P
<
0.05

). The scores of facial microexpression in the observation group were higher than those in the control group during the three postoperative intervention periods, with statistical significance (

P
<
0.05

). There was no significant difference in the pain score of the first day after surgery between the two groups (

P
=
0.298

). In the other two postoperative intervention periods, the pain score of the observation group was lower than that of the control group, with a statistically significant difference, and the difference was statistically significant (

P
<
0.05

). The threshold of chin and neck sensory pressure in the two groups was statistically significant (

P
<
0.05

) except that the “cheek in area 4” (

P
=
0.290

). Conclusion. The results showed that these interventions, such as the elevation of bed after operation, 24-hour intermittent cryotherapy, ice cubes in mouth, and the “meter” functional training, have good clinical effects on the symptoms of facial swelling and abnormal sensation of neck and face. It can accelerate the speed of edema dissipation, improve the patients’ postoperative comfort, and improve the satisfaction and quality of life of patients with the effect of surgery and beauty.
Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications
Authors: Gu Junling , Geng Kang , Guo Man , Huang Wei , Zhao Tingting , Li Xuling , Xu You-Hua , Xu Yong
Published: September 2022

Pyroptosis is an inflammatory form of programmed cell death that is dependent on inflammatory caspases, leading to the cleavage of gasdermin D (GSDMD) and increased secretion of interleukin (IL)-1β and IL-18. Recent studies have reported that hyperglycemia-induced cellular stress stimulates pyroptosis, and different signaling pathways have been shown to play crucial roles in regulating pyroptosis. This review summarized and discussed the molecular mechanisms, regulation, and cellular effects of pyroptosis in diabetic microvascular complications, such as diabetic nephropathy, diabetic retinopathy, and diabetic cardiomyopathy. In addition, this review aimed to provide new insights into identifying better treatments for diabetic microvascular complications.
Monitoring Area Coverage Based on Control Multimedia Nodes Position in Mixed Underwater Mobile Wireless Sensor Networks
Authors: Li Qiangyi , Liu Ningzhong
Published: September 2022

Due to the high cost of mobile nodes and the low cost of fixed nodes, in some applications of wireless sensor networks, in order to reduce the use cost, the mixed mode is used for node deployment. The deployed nodes include both fixed and mobile nodes. After the nodes are deployed, the fixed nodes do not move, and the mobile nodes move reasonably according to the network coverage to improve the network coverage effect. Due to the differences in equipment structure and use cost between fixed nodes and mobile nodes, in order to complete the monitoring task under the condition of reducing the use cost of wireless sensor networks, the number and position of mobile nodes can be reasonably adjusted as needed to improve the effective coverage area of wireless sensor networks. In the process of adjusting the position of mobile nodes, the moving distance of mobile nodes is fully considered. Simulation results show that this algorithm can improve the coverage effect of mixed wireless sensor networks and reduce the moving distance of mobile nodes.
[Retracted] Analysis of the Performance of Gadoxetic Acid Disodium MRI in Predicting Microvascular Invasion of Hepatocellular Carcinoma
Authors: Chen Jiao , Ming Xianfang , Wang Zhen , Ye Yu
Published: September 2022

Objective. This study aimed to evaluate the predictive value of gadoxetic acid disodium magnetic resonance imaging (MRI) in the microvascular invasion (MVI) of hepatocellular carcinoma (HCC). Methods. 87 HCC patients (2019‐01–2022‐01) admitted to the hospital were selected for retrospective analysis, gadoxetic acid disodium MRI scan was performed before surgery, and the patients were divided into two groups according to whether the MVI occurred, including the invasion group (n = 47) and the non‐invasion group (n = 40). The influencing factors of MVI in HCC patients were explored, independent risk factors were determined, and the correlation between independent risk factors and MVI in HCC patients was analyzed. Results. There were significant differences in tumor margin, peritumoral low signal (hepatobiliary phase), peritumoral enhancement (arterial phase), and peritumoral hyperintensity ring (arterial phase) between the two groups (P < 0.05). Logistic regression analysis showed that unsmooth tumor margin, peritumoral low signal (hepatobiliary phase), peritumoral enhancement (arterial phase), and peritumoral hyperintensity ring (arterial phase) were independent risk factors for MVI in HCC patients (P < 0.05). The results of Spearman correlation analysis showed that unsmooth tumor margin was negatively correlated with MVI in HCC patients (r = −0.66, P = 0.037). Moreover, peritumoral low signal (hepatobiliary phase), peritumoral enhancement (arterial phase), and peritumoral hyperintensity ring (arterial phase) were positively correlated with MVI in HCC patients (r1 = 0.63, r2 = 0.68, r3 = 0.72, P1= 0.030, P2 = 0.023, P3 = 0.017). Conclusion. Unsmooth tumor margin, peritumoral low signal (hepatobiliary phase), peritumoral enhancement (arterial phase), and peritumoral hyperintensity ring (arterial phase) are significantly correlated with MVI in patients with HCC, which can provide a reference for the formulation and implementation of clinical interventions.
Evaluation of the Students’ Learning Status in the Foreign Language Classroom Based on Machine Vision
Authors: Yao Lin , Qin Qiongfang
Published: September 2022

In order to improve the effectiveness of the evaluation of student’s learning status in foreign language classrooms, this paper applies machine vision to classroom teaching. Through an in-depth analysis of the relative motion relationship between the end marker points of classroom feature recognition and the center point of the machine vision system window, this paper first proposes an autonomous tracking motion algorithm of the machine vision system window based on the preset field of view parameters. Moreover, this paper realizes the motion function of the window to track the marker points autonomously, completes the simulation analysis through two sets of planned trajectories and two sets of master hands to collect the actual trajectories, and verifies the correctness and feasibility of the algorithm. The research study shows that the algorithm based on machine vision proposed in this paper can effectively judge the real-time state of students in the foreign language classroom.
Design and Management of Comprehensive Art Student Information Database from the Perspective of Internet plus Education
Authors: Liu Wenting , Wei Shihang
Published: September 2022

With the rapid development of information technology and network technology, all kinds of data increase exponentially, and the traditional relational databases cannot handle these data well, which is also reflected in the sharp increase in the number of college students. The amount of students' information is increasing exponentially and the simple management method in the past can no longer meet the needs of the new situation. This paper adopts B/S mode and three-tier architecture and relies on network technology and ASP.NET technology to design and implement the student information management system. The system is divided into eight functional modules: comprehensive information inquiry for students, scholarship evaluation, evaluation and award, economic recognition, student loan management, student violation, communication and feedback, and system management. Different operation interfaces are designed according to four users with different permissions: students, class tutors, college administrators, and student affairs offices. This paper describes the system analysis, design, and implementation in detail. The practice results show that the initial use of the student information database management reflects well and achieves the expected goal. The system is easy to maintain and extensible and has good application value. The operation of the system has greatly improved the management efficiency of student affairs and enabled the student affairs administrators to complete various student affairs more efficiently. Campus information construction is becoming an important part of the overall construction of colleges and universities, and it is also a basic and continuous work. Accelerating the establishment of a set of comprehensive, perfect, and efficient student comprehensive management information systems is an urgent need to promote the modernization of college student management. The modernization, informatization, and standardization of college student management are a complex systematic project. Only by relying on modern information technology can we cope with the base pressure brought by the continuous enrollment expansion of college students, promote the flat and intensive utilization of college management information, and improve the efficiency and quality of service.
Joint Promotion of Online Retail Based on Promotional Effort under the Shopping Festival Background
Authors: Zhao Jinghua , Zhang Wei , Feng Juan , Zhang Yan , Ma Shujiao
Published: September 2022

With the prevalence of shopping festivals launched by e-commerce platforms, online retailers and customers are gradually showing signs of fatigue. In order to enrich the promotion strategies of the shopping festivals, break the bottleneck, and achieve mutual benefit, this paper proposes three promotional models based on platform-based promotional effort, namely, the joint promotion model with no promotional effort, the joint promotion model with only the platform putting in the promotional effort, and the joint promotion model with the platform and the e-retail sharing the promotional effort. The study shows that the platform and the online retailer's promotion strategies are influenced by the commission factor and the promotional effort cost-sharing factor. When the latter factor is appropriate, it is more beneficial for the e-retailer to choose the cost-sharing strategy of promotional effort. In addition, the platform investing in promotional effort not only improves its profits, but also helps maximize the profits of the e-retailer. The study further finds that consumers acquire the maximum discounts when there is no promotional effort. As the promotional effort is invested, the discount declines and the demand rises instead.
Analysis on Innovation Path of Business Administration Based on Artificial Intelligence
Authors: Lu Ben
Published: September 2022

In order to effectively promote the efficiency of retail enterprises, the innovation path of business administration based on artificial intelligence is studied. Through a questionnaire survey, collect the relevant data of retail enterprise value network, business model innovation, and enterprise benefits, and through regression analysis. The experimental results show that before the business model innovation, the coefficients of internal value network innovation and external value network innovation are 0.413 and 0.258, respectively. After the business model innovation is added, the coefficients of the two are reduced to 0.208 (

p
=
0.012
<
0.05

) and 0.113 (

p
=
0.005
<
0.01

). In addition, the coefficients of the two dimensions of business model innovation are significant at the 1% level. Conclusion. Both internal value network innovation and external value network innovation have a significant positive impact on the functional business model innovation and artificial intelligence business model innovation of retail enterprises. Functional business model innovation and artificial intelligence business model innovation have a significant positive impact on the financial and market benefits of retail enterprises. Internal value network innovation and external value network innovation have a significant positive impact on the financial and market benefits of retail enterprises. Business model innovation plays an intermediary role in the relationship between internal value network innovation, external value network innovation, and the financial and market benefits of retail enterprises.
Dynamical Behaviours of Stage-Structured Fractional-Order Prey-Predator Model with Crowley–Martin Functional Response
Authors: Mahdi Wala’a A. , Al-Nassir Sadiq
Published: September 2022

In this paper, the dynamic behaviour of the stage-structure prey-predator fractional-order derivative system is considered and discussed. In this model, the Crowley–Martin functional response describes the interaction between mature preys with a predator. The existence, uniqueness, non-negativity, and the boundedness of solutions are proved. All possible equilibrium points of this system are investigated. The sufficient conditions of local stability of equilibrium points for the considered system are determined. Finally, numerical simulation results are carried out to confirm the theoretical results.
Enhancing the Applicability of Satellite Remote Sensing for

PM

2.5

Estimation Using Machine Learning Models in China
Authors: Chai Jun , Song Jun , Xu Yawen , Zhang Le , Guo Bing
Published: September 2022

Numerous studies and monitoring data indicate that fine particle (

PM

2.5

) pollution in China is still comparatively severe. Given the sparse and uneven distribution of air quality monitoring base stations established in China and the limitation of geographical conditions, inversion of aerosol optical depth by satellite remote sensing can achieve low-cost air quality monitoring in global areas. In this study, we use the machine learning algorithm XGBoost to build a prediction model to achieve nationwide average

PM

2.5

concentration prediction. Meanwhile, we used aerosol data from Moderate Resolution Imaging Spectroradiometer (MODIS) in a specific band, combined with a land use regression (LUR) model as predictors of surface

PM

2.5

concentrations in China, for the period Dec. 2019-Nov. 2021. In order to provide more accurate

PM

2.5

concentration prediction, the correspondence between

PM

2.5

and aerosol optical depth (AOD) under different seasons was studied. The coefficients of determination (R2) for different seasons are 0.86 (spring), 0.80 (summer), 0.90 (autumn), and 0.88 (winter), indicating that the fit is best for autumn and worse for summer. The study shows the potential usefulness of using the LUR model with the XGBoost algorithm for predictive assessment of

PM

2.5

spatial distribution.
Clinical Efficacy Analysis of Biofeedback Electrical Stimulation Combined with Doxycycline in the Treatment of Type IIIA Chronic Prostatitis
Authors: Sun Xiaoyong , Lin Tangtang , Fang Jinying , Liu Jinming , Yao Wenliang , Geng Liguo , Zhang Jinfeng
Published: September 2022

Purpose. To analyse the clinical efficacy of biofeedback electrical stimulation combined with doxycycline in the treatment of type IIIA chronic prostatitis. Methods. Eighty patients who met the diagnostic criteria of type IIIA chronic prostatitis in our hospital between February 2020 and February 2022 were selected and equally divided into the drug group and electrical stimulation group according to the random number table method. The drug group was treated with medication alone for 4 weeks; the electrostimulation group was treated with biofeedback electrostimulation on top of medication for 12 weeks. The expressed prostatic secretious (EPS) routine (lecithin bodies, white blood cells) and the maximum urinary flow rate (Qmax) and mean urinary flow rate (Qave) were measured before and after treatment in both groups, and the National Institutes of Health chronic prostatitis symptom index (NIH-CPSI) was used to score the urinary symptom, pain or discomfort, and quality of life and determine the efficacy of the treatment in both groups. Results. After treatment, the number of lecithin bodies and white blood cells in EPS improved significantly in both groups compared to before, and both the electrical stimulation group was better than the drug group (P<0.05). After treatment, the Qmax and Qave were significantly higher in both groups than before, and both the electrical stimulation groups were higher than the drug group (P<0.05). After treatment, the urinary symptom scores, pain or discomfort scores, quality of life scores, and total NIH-CPSI scores were significantly lower in both groups than before, and all were lower in the electrical stimulation group than in the drug group (P<0.05). After treatment, the overall efficiency of patients in the electrical stimulation group was significantly higher than that of the drug group (P<0.05). Conclusion. Biofeedback electrical stimulation combined with doxycycline in the treatment of type IIIA chronic prostatitis can synergistically improve the patient’s inflammation level, urinary dysfunction, relieve pelvic floor tension myalgia, and improve their quality of life, opening up new avenues for the rehabilitation of patients with type IIIA chronic prostatitis.
Study on the Impact of High‐Quality Economic Development and Flood Resilience on Flood Damage in the Yangtze River basin: Evidence from Provincial Administrative Regions in the Yangtze River Basin
Authors: Zhang Qichun , Miao Zihao
Published: September 2022

China’s economic development has shifted from a high‐speed growth stage to a high‐quality development stage, which promotes the sustainable economic development of the Yangtze River (YR) and also improves the response capacity of the YR basin’s resilience system to floods. Flood resilience (FR) is not only just the achievement of high‐quality economic development (HQED) but also the key to mitigating flood damage (FD). Therefore, based on panel data from 2000 to 2019 from provincial administrative regions (PARs) in the Yangtze River basin (YRb), the entropy weight method and the quantitative regression analysis method were used to empirically investigate the impact of HQED and FR on FD in the YRb. The empirical analysis results show the following. (i) HQED has an inverted U‐shaped effect on FD in the YRb, meaning that HQED will reach a certain point and reduce flood losses. (ii) The HQED model, which has been pushed forward, will significantly improve the level of FR. Various mediating effect test methods revealed that FR has a significant negative mediating effect on the process of HQED to mitigate FD. Taken together, this reveals the importance of insisting on implementing an HQED model to mitigate FD in the YRb, gradually deriving an FR that is adapted to floods and has a high self‐organizing and self‐restoring capacity through high‐quality development.
[Retracted] Efficacy and Safety of Peginterferon α‐2a and Entecavir Tenofovir in the Treatment of Chronic Hepatitis B Genotype C
Authors: Yu Jiao , Xu Dong
Published: September 2022

This article discusses the clinical value of Pegylated Interferon (PEG‐IFN) α‐2a combined with entecavir or tenofovir in the treatment of Chronic Hepatitis B (CHB) genotype C patients. 78 patients with CHB genotype C were divided into three groups: control group, entecavir group, and tenofovir group according to different treatment methods. The efficacy and adverse reaction (AR) of the three groups are observed during 12 months of treatment and after drug withdrawal, and the clinical efficacy and safety of the three treatment methods are evaluated. The experimental results show that the sustained response rate (RR) in the tenofovir and entecavir groups is higher than that in the controls. The incidence of total AR in the tenofovir group is significantly higher than that in the control and entecavir groups. PEG‐IFN α‐2a and entecavir or tenofovir are more effective, and tenofovir has an antiviral effect.
Serological Characteristics, Etiological Analysis, and Treatment Prognosis of Children with Congenital Hypothyroidism
Authors: shen Lin , Ding Jingchao
Published: September 2022

Objective. The aim of the study is to analyze the serological features, etiology, and prognosis of congenital hypothyroidism (CH) treated with L-thyroxine sodium (L-T4). Methods. A total of 126 CH children in our hospital from June 2015 to January 2020 were selected as the research objects, and L-T4 treatment was given immediately after diagnosis. After diagnosis and 24 months of treatment, laboratory serum thyroid function-related indicators were examined, and thyroid changes were determined by ultrasound. We compared serum thyroxine levels in children with different thyroid changes, compared serum thyroid hormone levels, serum ghrelin levels, and body mass index (BMI) changes in children with CH before treatment and after 24 months of treatment, and analyzed the prognosis of treatment in children. In terms of thyroid changes in 126 CH children, 32 cases (25.40%) had a normal thyroid gland, 16 cases (12.70%) had a hypoplastic thyroid gland, 40 cases (31.75%) had an ectopic thyroid gland, 28 cases (22.22%) had an absent thyroid gland, and 10 cases (7.93%) had an enlarged thyroid gland, with an ectopic thyroid gland being the most common. In terms of serological expression of CH children, the TSH level in children with thyroid dysplasia was significantly higher than that in children with basic normal and T3 and T4 levels were significantly lower than those in children with basic normal (

P
<
0.05

). At the same time, the TSH level in children with thyroid absence, ectopic, and enlargement was increased, while thyroxine (T4) and tri-iodothyronine (T3) levels were decreased compared with those in children with thyroid dysplasia. The difference was statistically significant (

P
<
0.05

). Univariate analysis showed that there were statistically significant differences in birth weight, week of gestation at delivery, maternal age at childbirth, household registration, and a family history of thyroid disease compared between the two groups (

P
<
0.05

); multivariate logistic regression analysis showed that birth weight <2,500 g, maternal age >35 years, rural residence, and a family history of thyroid disease were risk factors for neonatal CH (

P
<
0.05

). Serum thyroid-stimulating hormone (TSH) levels, serum ghrelin levels, and the body mass index of children with CH decreased significantly, and T4 levels increased significantly after 24 months of treatment (

P
<
0.05

). Conclusion. Screening for common causes of CH is conducive to timely detection of children with CH, and L-T4 treatment can effectively improve thyroid function in children.
Dynamic Analysis of an HIV Model Incorporating Cytotoxic T Lymphocytes and Vectored Immunoprophylaxis
Authors: Chen Hongyan , Luo Jianfeng
Published: September 2022

The objective of this study is to investigate the effects of immune responses on HIV replication by using a novel HIV model that incorporates immune responses including cytotoxic T lymphocytes and antibodies. In this model, the cytotoxic lymphocyte cells are stimulated by infected T cells, and the antibodies are received continuously through vectored immunoprophylaxis. In the first step, we analyze the well‐posedness of our proposed model. By obtaining the basic reproduction number, we also investigate the existence of equilibrium in three cases, including infection‐free equilibrium, immune‐free infection equilibrium, and immune‐present infection equilibrium. As a result, we demonstrate our model can admit two immune‐free infection equilibria, which are dependent on the basic reproduction number. Additionally, we study their local stability and find sufficient conditions for them. In particular, we show that immune‐free infection equilibrium and immune‐present infection equilibrium can become unstable from stable, and then a simple Hopf bifurcation can occur. Theoretical results about backward bifurcation and forward bifurcation are further derived. In addition, simulations reveal rich dynamic behaviors, such as backward bifurcation, forward bifurcation, and Hopf bifurcation. The rich dynamics of the proposed model demonstrate the importance and complexity of immune responses when fighting HIV replication.
Correlation Analysis between Early Reading Amount and Expressive Ability of Young Children Aided by Multiple Information Processing Techniques under the Heuristic Pattern
Authors: Duan Fude , Zhou Jianhua , Li Peng
Published: September 2022

The cultivation of reading ability runs through a child’s life. Children are in a critical period of early reading ability formation. Only based on the actual development characteristics of children and adopting effective training methods, can early childhood educators better meet the needs of children’s long-term development. Based on the data of 22 classes in 7 public kindergartens in X City in Mainland of China, this study first compared the effects of two different teaching modes and then analyzed the relationship between early reading amount and expressive ability of children. Independent sample T test, OLS regression, and Lasso regression were used to demonstrate the correlation between early reading amount and expressive ability, and the possible mechanisms of family background are also explored. The results show the following: firstly, heuristic teaching mode has positive teaching effect. The effect quantities of heuristic teaching mode on transmission ability, communication ability, transfer ability, and generalization ability are 0.21, 0.25, 0.31, 0.30, and 0.32, respectively, which belong to medium intensity, indicating that heuristic teaching mode has a good intervention effect on improving students’ expression ability. Secondly, there is a high correlation between early reading and children’s expressive ability. Thirdly, there are two aspects of the influence of early reading amount on children’s expressive ability: explicit influence and implicit influence. Fourthly, the association between early reading and different presentation skills is not the same. To sum up, we should actively encourage the use of heuristic teaching mode, realize the heterogeneity of early reading amount, and promote the improvement of children’s expressive ability through both explicit and implicit paths.
[Retracted] Observation of the Curative Effect of Acupuncture for Tonifying Kidney and Removing Blood Stasis Combined with Radiofrequency Surgery in Patients with NSCLC and the Diagnostic Efficacy of Combined Detection of NTx, BGP, and CYFRA21‐1 in the Occurrence of Bone Metastases
Authors: Song Ge , Jiang Tian , Wang Ying , Gu Tao , Li Wentao
Published: September 2022

The curative effect observation of acupuncture for tonifying kidney and removing blood stasis combined with radiofrequency surgery in patients with non‐small‐cell lung carcinoma (NSCLC) and the diagnostic efficacy of combined detection of NTx, BGP, and CYFRA21‐1 for bone metastases are investigated. 122 NSCLC patients admitted to our hospital from January 2019 to December 2021 are selected for the examination, and the two sets of patients are randomly divided into the study set and the control set using the random number table method, with 61 cases in each set. Patients in the control set are given CT‐guided percutaneous radiofrequency ablation therapy, and patients in the study set are given a combination of acupuncture therapy for tonifying the kidney and removing blood stasis on the basis of the therapy of the control set. The experimental results show that for NSCLC patients, the application of kidney‐tonifying and stasis‐removing acupuncture therapy combined with radiofrequency surgery can notoriously enhance the clinical therapy effect and enhance the quality of life of patients, and the detection of NTx, BGP, and CYFRA21‐1 indicators can effectively predict the prognosis.
Influences of Aqueous Nanofluid Emulsion on Diesel Engine Performance, Combustion, and Emission: IoT (Emission Monitoring System)
Authors: Venkatesh B. , Babu J. Chinna , Mathivanan Sandeep Kumar , Jayagopal Prabhu , Prasanna S. , Uddin Md Salah
Published: September 2022

Pollution is the primary ecological threat to nature and it also raises the temperature of the Earth. The primary cause of air pollution is exhaust emissions from the combustion chamber. This study aims to focus on controlling emissions using an aqueous nanoemulsion method and to analyze positive vibrations for the reduction of pollutants in diesel engines. In this study 3% NWED (nano-based water emulsion diesel), 7% NWED, and 12% NWED emulsion blended diesel were mixed with Tween-20 as a solvent. In addition, this work was accomplished with a multiuser remote control system for the continuous monitoring of emissions with IoT technology applied to diesel engines. Experimental results have been measured with an IoT kit and five gas analyzers and reported that emission of oxides of nitrogen and hydrocarbons can be reduced by using a 7% NWED blend when compared with diesel. In addition, the experimental result also shows that the brake-specific fuel consumption is reduced with an improvement in thermal efficiency at 7% NWED when compared with other blends.
Performance and Exhaust Emission Characteristics of C.I Engine Using Biofuels and Its Diesel Blend with Nano-Additives
Authors: Jacob S. , Karikalan L. , JoshuaRamesh Lalvani J. Isaac , Sharma Aman , Kannappan Maghalengam
Published: September 2022

Depletion of fossil fuel assets makes it critical that we find biodiesel sources in the contemporary world. This work investigates dual bio-fuels of jatropha methyl ester and mahua methyl ester in various proportions, such as 15 : 5, 10 : 10, and 5 : 15. The performance and emission characteristics of JME15MME5, JME10MME10, and JME5MME15 blends of jatropha methyl ester and mahua methyl ester are suitable for diesel engines with little air pollution. Biodiesel blends with titanium dioxide nano-additives, such as jatropha methyl ester and mahua methyl ester, might be more efficient at the conclusion of the experiment, preserving fossil fuel assets for future generations. Performance parameters like BTE and SFC with different load conditions are analyzed for various blends, and then final results are drawn.
Total Active Compounds and Mineral Contents in Wolffia globosa
Authors: Monthakantirat Orawan , Chulikhit Yaowared , Maneenet Juthamart , Khamphukdee Charinya , Chotritthirong Yutthana , Limsakul Suphatson , Punya Tanakorn , Turapra Buntarawan , Boonyarat Chantana , Daodee Supawadee
Published: September 2022

Wolffia globosa, or watermeal, is an aquatic plant belonging to the Lemnaceae family that is consumed as food and sold in local markets of Thailand. The aim of this study was to quantify selected active compounds and minerals in W. globosa ethanolic extract and evaluate its antioxidant activity. Total phenolic, flavonoid, and anthocyanin contents were analyzed. High-performance liquid chromatography was used for the determination of beta-carotene, ferulic acid, luteolin-7-O-β-D-glucoside, and kaempferol. Mineral contents (iron, potassium, calcium, magnesium, zinc, and sodium) were determined by atomic absorption spectroscopy. Antioxidative activity was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2′-azobis (3-ethylbenzothiazoline-6-sulfonic acid)) radical scavenging assays. The beta-carotene, ferulic acid, luteolin-7-O-β-D-glucoside, and kaempferol contents of the extract were 2.52 ± 0.10, 1.40 ± 0.10, 2.42 ± 0.50, and 1.57 ± 0.14 mg/g extract, respectively. The highest mineral content in the W. globosa extract was magnesium. The wet extract of W. globosa showed higher amounts of all minerals than the dry extract. Freshly prepared and boiled W. globosa extracts showed radical scavenging activity at 1000 µg/milliliter with 75.77 ± 0.93% and 67.10 ± 0.20% inhibition of DPPH and 70.40 ± 7.20% and 59.78 ± 3.16% inhibition of ABTS, respectively. This plant is a promising novel source of natural phytochemical constituents and antioxidants and has potential for development as a plant-based nutraceutical product for the treatment of diseases caused by free radicals.
Multiparty Threshold Private Set Intersection Protocol with Low Communication Complexity
Authors: Yu Xiaopeng , Li Fagen , Zhao Wei , Dai Zhengyi , Tang Dianhua
Published: September 2022

Multiparty threshold private set intersection (MP-TPSI) protocol allows

n

mutually untrusted parties

P

1

,

P

2

,
…
,

P

n

holding data sets

A

1

,

A

2

,
…
,

A

n

of size

m

respectively to jointly compute the intersection

I
=

A

1

∩

A

2

∩
⋯
∩

A

n

over all their private data sets only if the size of intersection is larger than

m
−
t

, while ensuring that no other private information of the data sets other than the intersection is revealed, where

t

is the threshold. In the MP-TPSI protocol, multiple parties first decide whether the size of the intersection is larger than the threshold

t

; then, they compute the intersection if the size of the intersection is larger than the threshold

t

. However, the existing MP-TPSI protocols use different forms of evaluation polynomials in the cardinality testing and intersection computing phases, so that parties need to transmit and calculate a large number of evaluation values, which leads to high communication and computational complexity. In addition, the existing MP-TPSI protocols cannot guarantee the security and the correctness of the results, that is, an adversary can know the additional information beyond the intersection, and the elements that are not in the intersection are calculated as the intersection. To solve these issues, based on the threshold fully homomorphic encryption (TFHE) and sparse polynomial interpolation, we propose an MP-TPSI protocol. In the star network topology, the theoretical communication complexity of the proposed MP-TPSI protocol depends on the threshold

t

and the number of parties

n

, not on the size of set

m

. Moreover, the proposed MP-TPSI protocol outperforms other related MP-TPSI protocols in terms of computational and communication overheads. Furthermore, the proposed MP-TPSI protocol tolerates up to

n
−
1

corrupted parties in the semi-honest model, where no set of colluding parties can learn the input of an honest party in the strictest dishonest majority setting.
Transgelin-2 Involves in the Apoptosis of Colorectal Cancer Cells Induced by Tanshinone-IIA
Authors: Zhang Yingru , Zhao Yiyang , Liu Jingwen , Li Chunpu , Feng Ying , Jiang Shasha , Sun Xiaoting , Hu Xueqing , Wang Yan
Published: September 2022

Tanshinone IIA (TanIIA) is the main active ingredient in the fat-soluble components isolated from Salvia miltiorrhiza Bunge. Our previous studies have convincingly proved that TanIIA is an effective drug against human colorectal carcinoma cells. In order to further demonstrate the effect of TanIIA on CRC, we carried out exploratory research about it in vivo and in vitro. The results demonstrated that TanIIA were observably more effective than control group in preventing tumor growth, and it has increased the survival time. Cancer cells viability and proliferation were accompanied by concentration and time dependent decline reached with TanIIA. We found that TanIIA altered the morphology of cytoskeleton and it could obviously induce apoptosis of colorectal cancer cells and block the cells in the G0/G1 phase. TanIIA also increased phosphorylation of p38MAPK, upregulated ATF-2 expression and downregulated Transgelin-2 expression, which could be reversed by SB203580, a p38MAPK-specific inhibitor. Our results suggested that TanIIA could induce apoptosis of colorectal cancer and block the cells in G0/G1 phase involved in downregulating the expression of Transgelin-2 through p38MAPK signal pathway.
Minimum Aberration Split-Plot Designs When the Whole Plot and Subplot Factors Do Not Have the Same Importance
Authors: Zhao Shengli , Zhao Qianqian
Published: September 2022

In practical factorial experiments, we sometimes find that complete randomization of the order of the runs is infeasible because it is more difficult to change the levels of some factors than the others, especially in some engineering experiments. Then, fractional factorial split-plot (FFSP) designs represent a practical option in such situations. The difficult-to-change factors are called whole plots (WP) factors, and the other factors are called subplot (SP) factors. The WP and SP factors do not have the same importance in many experiments. Then, the popular minimum aberration criterion is not suitable any more for choosing FFSP designs. This paper proposes two criteria for selecting FFSP designs. Algorithms for constructing the optimal FFSP designs under the two criteria are proposed. Some optimal designs under the two criteria are tabulated.
Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis
Authors: SanMiguel Jennifer M. , Eudy Elizabeth , Loberg Matthew A. , Young Kira A. , Mistry Jayna J. , Mujica Kristina D. , Schwartz Logan S. , Stearns Timothy M. , Challen Grant A. , Trowbridge Jennifer J.
Published: September 2022

Clonal hematopoiesis resulting from the enhanced fitness of mutant hematopoietic stem cells (HSC) associates with both favorable and unfavorable health outcomes related to the types of mature mutant blood cells produced, but how this lineage output is regulated is unclear. Using a mouse model of a clonal hematopoiesis–associated mutation, DNMT3AR882/+ (Dnmt3aR878H/+), we found that aging-induced TNFα signaling promoted the selective advantage of mutant HSCs and stimulated the production of mutant B lymphoid cells. The genetic loss of the TNFα receptor TNFR1 ablated the selective advantage of mutant HSCs without altering their lineage output, whereas the loss of TNFR2 resulted in the overproduction of mutant myeloid cells without altering HSC fitness. These results nominate TNFR1 as a target to reduce clonal hematopoiesis and the risk of associated diseases and support a model in which clone size and mature blood lineage production can be independently controlled to modulate favorable and unfavorable clonal hematopoiesis outcomes.

Significance:

Through the identification and dissection of TNFα signaling as a key driver of murine Dnmt3a-mutant hematopoiesis, we report the discovery that clone size and production of specific mature blood cell types can be independently regulated.

See related commentary by Niño and Pietras, p. 2724.

This article is highlighted in the In This Issue feature, p. 2711
DDR2 Coordinates EMT and Metabolic Reprogramming as a Shared Effector of FOXQ1 and SNAI1
Authors: Mitchell Allison V. , Wu Jason , Meng Fanyan , Dong Lun , Block C. James , Song Won-min , Zhang Bin , Li Jing , Wu Guojun
Published: September 2022

While multiple transcription factors (TF) have been recognized to drive epithelial–mesenchymal transition (EMT) in cancer, their interdependence and context-dependent functions are poorly understood. In this study, we show that FOXQ1 and SNAI1 act as independent TFs within the EMT program with a shared ability to upregulate common EMT-TFs without reciprocally impacting the expression of one another. Despite this independence, human mammary epithelial cells with ectopic expression of either FOXQ1 or SNAI1 share a common gene set that is enriched for a DDR2 coexpression signature. Further analysis identified DDR2 as the most upregulated receptor tyrosine kinase and a shared downstream effector of FOXQ1 and SNAI1 in triple-negative breast cancer (TNBC) cell lines. Alteration of DDR2 expression in either FOXQ1- or SNAI1-driven EMT models or in TNBC cells resulted in a profound change of cell motility without significantly impacting EMT marker expression, cell morphology, or the stem cell population. Finally, we demonstrated that knockdown of DDR2 in the FOXQ1-driven EMT model and TNBC cell line significantly altered the global metabolic profile, including glutamine-glutamate and aspartic acid recycling.

Significance:

The critical role of DDR2 in cancer metastasis has been well established. However, the exact function of DDR2 in driving cancer metastatic progression remains unclear. The results of our current study provide new insights into the cancer-driving function of DDR2, suggesting that DDR2, as a shared effector of the EMT program, may drive tumor progression by promoting breast cancer cell motility and metabolic reprogramming.
Adaptation of Melodic Intonation Therapy to a Tone Language: A Pilot Study of Tone-Rhythmic Therapy in Mandarin Chinese
Authors: Chen Wenjun , Qian Qian , van de Weijer Jeroen , Zhu Shuangshuang , Wang Manna
Published: September 2022

Introduction: Although melodic intonation therapy (MIT) has proven effective in individuals with non-fluent aphasia in a variety of western languages, its application to Mandarin-speaking aphasic patients has not been thoroughly studied. The adaptation is complicated because Mandarin Chinese is a tone language with specific prosodic elements that differ from Indo-European languages. This study developed a Chinese-specific variant of MIT, i.e., tone-rhythmic therapy (TRT), and tested its efficacy in individuals with non-fluent aphasia. Methods: Six non-fluent aphasic patients were recruited; all of them were admitted to the study over 6 months after stroke and had received a standard program of language therapy. In the current research, tone and rhythmic practice were incorporated into the training procedures, and the adaptation was then examined in patients. The TRT treatment lasted 6 weeks, with five 50-min sessions per week. The Boston Diagnostic Aphasia Examination (BDAE) and the Functional Assessment of Communication Skills for Adults (FACS) tests were used to measure the change in the speech and language skills of patients. Results: The results showed that the patients had increased BDAE and FACS scores after intervention, and the treatment effect lasted for 6 months. Discussion: The modified MIT proved effective for Mandarin-speaking patients with non-fluent aphasia with lasting effects. Further studies evaluating its efficacy are needed for other types of aphasia and other tone languages.