bluuebunny/crossref_metadata_2025 huggingface dataset:
Features of hemostasis in patients with non-ST-elevation myocardial infarction
Authors: Popovici Mihail , Ciobanu Lucia , Popovici Ion , Ivanov Victoria , Ivanov Mihaela , Popovici Ion Ion , Danila Tatiana , Cobet Valeriu
Published: February 2023

Background: Coronary thrombosis is the key pathogenic mechanism of acute heart attack, including non-ST segment elevation (NSTEMI). Given that, the detection of reliable markers of hemostasis disorders is important in the process of optimizing the diagnosis of NSTEMI. Material and methods: The study was conducted on 54 patients with NSTEMI (average age 69.7±1.5 years). In 60% of cases, 3-vessel disease was noted; 56% of patients had ejection fraction >50%, and Killip class I of heart failure was revealed in 78% of patients. With the help of the STA-Liatest (France) equipment, the blood tests determined the following hemostasis markers: fibrin monomers (FM), thrombotic complex activity of factors II, VII and X. Additional markers like Procoag, the coagulation indicator dependent on circulating phospholipids or SPA, D-dimers, as well as factors C, S and antithrombin III were appreciated. The values of these markers determined by the same method in 20 healthy persons (control group) were used as normal values. Results: Circulating level of FM on admission was increased twice, while the values of Procoag and SPA were significantly decreased by 35.3% compared to the control. Factors C, S and antithrombin III were 54-80% of the control value range, and D-dimers were within the permissible values. In the acute phase of the heart attack, a deterioration of hemostasis indicators was noted, excepting the D-dimers. The levels of FM determined 24 and 72 hours after revascularization were consistently increased (up to 3.8 times) compared to the control, while Procoag and SPA decreased by 54-57%. Further reduction of factors C, S and antithrombin III accounted for 42-54% of normal indicators. After 5 days, an improvement in hemostasis markers was observed, but a significant difference still remained comparing to the control group. Conclusions: The hemostasis particularities discovered in patients with NSTEMI indicate the features of an activated prothrombotic status, and FM could be an important diagnostic marker of NSTEMI, due to its most significant deviation from the normal value (>100%). It can reliably reflect the thrombin level, which triggers the last enzymatic phase of thrombus formation.
Low-grade systemic inflammation in subclinical hypothyroidism
Authors: Vudu Stela , Krishna Gouri Durga
Published: February 2023

Background: Hypothyroidism is the deficiency in the production of thyroid hormones to meet the requirements of peripheral tissues. Subclinical hypothyroidism (SCH) is defined biochemically as normal serum free thyroxin concentration in the presence of an elevated serum thyroid-stimulating hormone (TSH) concentration. SCH may be associated with low-grade systemic inflammation (increased high sensitivity-C reactive protein (hs-CRP), one possible explanation may be that TSH in adipocytes promotes the release of interleukin-6 (IL-6). Studies have confirmed inflammatory biomarkers like hs-CRP and IL-6 to be a predictor of cardiovascular (CV) events. However, the treatment of SCH remains subject to debate. Conclusions: It is increasingly evident that SCH has prognostic values and crucial clinical effects, which leads to the view of SCH not being a compensated biochemical change sensu strictu. Even a modest but consistent fluctuation in the circulating thyroid hormone levels can create a response from the human heart. Well-timed treatment should be considered as a precaution to avoid the unfavourable CV diseases. The inflammatory biomarkers, namely CRP and IL-6 are exceptionally robust markers of cardiovascular risk. Thus, using these biomarkers may be helpful in assessing the cardiovascular risk in patients with subclinical hypothyroidism.
Evaluation of p57 expression in early disordered pregnancies with molar status vs non-molar ones
Authors: David Valeriu , Petrovici Vergil , Saptefrati Lilian , Fulga Veaceslav , Carpenco Ecaterina , Frant Elena
Published: February 2023

Background: The molar and non-molar lesions are determined during histomorphological examination and treated as inconclusive. The establishing of a marker by immunohistochemical investigations could influence the accuracy of the morphopathological diagnosis. The aim is evaluation of p57 immunoexpression in the trophoblastic germ compartment in molar and non-molar pregnancies. Material and methods: Abortion products from 15 patients with hydatidiform mole, 18 pregnancies solved on social indications and 16 short-term disordered pregnancies were evaluated depending on the immunoexpresion of p57. Results: The hydatidiform mole was classified based on anti-p57 immunoexpression into: complete hydatidiform mole – 8 cases (negative immunoexpression or expression in ˂10% of villous cytotrophoblast) and partial hydatidiform mole – 7 cases (positive expression in ˃10% of the villous cytotrophoblast). Basal deciduous and extravillous cytotrophoblasts were positive in 100% of cases and served as internal control. Hepatocytes were used as negative control. In the control group, the positive immunoexpression was attested in >10% of cases in the villous trophoblast. Conclusions: Differential immunoexpression of p57 protein in the germinal cytotrophoblast allows subclassification of molar pathology into complete and partial forms, while not allowing the differentiation between partial hydatidiform mole and non-molar lesions. Immunohistochemical evaluation of p57kip2 protein in molar and non-molar pathology is useful in differential diagnosis as a complementary method.
Morphological evaluation of the amniotic membrane decellularization
Authors: Ignatov Olga , Cociug Adrian , Pascal Oleg , Nacu Viorel
Published: February 2023

Background: Biological materials derived from decellularized tissues could be a good basis for progress in regenerative medicine while maintaining the main components of the extracellular matrix. A promising scaffold for tissue-engineered is the human amniotic membrane. It is one of the oldest biomaterials used for scaffolds. Material and methods: 3 placentas were obtained through Human Tissue Bank. Under sterile condition human amniotic membrane was collected. The human amniotic membrane was treated with 0.5% of sodium dodecyl sulphate (SDS), 1% Triton for 24 and 5 hours. Amniotic membrane decellularization was also carried out in combination with ultrasound bath for 20 minutes 3 times. For morphological and structure evaluation of human amniotic membrane the scanning electron microscopy of native amniotic membrane and histology of decellularized and native amniotic membrane were performed. Results: The human amniotic membrane decellularization process with 0.5% SDS solution and 1% Triton solution showed that decellularization for 24 hours is too aggressive for human amniotic membrane structure. The decellularization for 5h with 1% Triton solution was incomplete. Conclusions: The method of decellularization with 0.5% SDS solution is more suitable for amniotic membrane decellularization and can be performed in only 5 hours. The use of ultrasound bath did not have a significant effect on the obtained results.
Vitamin D2 versus vitamin D3 as a risk factor in compromised bone health
Authors: Voloc Chiril , Rotari Aliona , Voloc Alexandru , Kuissi Kamgaing Eliane , Djoba Siawaya Joel Fleury , Ategbo Simon Jonas
Published: February 2023

Background: Vitamin D plays an important role in the prevention of many diseases. More than 1 billion people worldwide suffer from vitamin D deficiency. Vitamin D deficiency can contribute to the development of 16 types of cancer (breast, colon, prostate, etc.), cardiovascular diseases, stroke, autoimmune diseases, periodontal pathologies, transplant failure in endo-alveolar surgery, etc. There are several risk factors that would prevent the achievement of treatment objectives. The national protocol for deficiency rickets prevention privileges vitamin D2 versus vitamin D3, which creates a medical risk factor compromising oral health in both children and adults. The article provides sufficient arguments in favour of vitamin D3 vs vitamin D2 prescription for prophylactic and treatment purposes. Conclusions: Considering that vitamin D deficiency is currently a global public health problem, it can be proposed to declare vitamin D deficit/deficiency a priority public health problem at the national level. Vitamin D3 should be elective in preventing deficit. Taking into account the multitude of acute and chronic diseases related to vitamin D deficiency, in order to improve the status of vitamin D in all population categories, it is necessary to include vitamin D3 in the list of molecules fully subsidized by the state and distributed free of charge at least to children under the age of 5 years and adolescents in the period of intensive growth.
Factors to consider when assessing the severity of COVID-19
Authors: Civirjic Ivan , Sandru Serghei , Arnaut Oleg , Cernei Natalia , Moghildea Victoria
Published: February 2023

Background: Analysis and evaluation of the multitude of parameters that impact and mirror clinical evolution of COVID-19 infection. Narrative literature review type of study. Bibliographic search of the PubMed database, applying the keywords: ”SARS-CoV-2”, ”COVID-19”, ”risk score”, ”laboratory parameters”, ”pathophysiology”, ”cytokine storm”, ”imaging evaluation”, “outcomes”, “clinical evolution”, which were combined with each other. There were selected English-language publications, in extenso, published in recognized journals from March 2020. Priority in the analysis was given to articles of critical synthesis of literature, randomized studies, those with large samples of patients. One of the clinically important symptoms that reflects severe or critical clinical evolution is persistent fever during the time. The presence of comorbidities, especially associated with obesity, represents a high risk of severe evolution. Proinflammatory, prothrombotic and systemic endothelial damage processes are represented by changes in platelet count, lymphocytes, neutrophil / lymphocyte ratio, C-reactive protein, D-dimers, fibrinogen, procalcitonin, urea, creatinine, ALS, AST, interleukin-6 and serum ferritin. Bacterial and fungal infections negatively influence clinical evolution. Common prediction scores have low value in COVID-19 patients and need adaptation. Imaging evaluation identifies the type of lung injury and correlates with the severity degree and outcome. Conclusions: COVID-19 disease caused by SARS-CoV-2 virus includes a multitude of pathophysiological changes that through its mechanism represent a systemic nosology. The complete analysis of all the factors and parameters that can influence its clinical evolution is a basic component of the decision-making steps and treatment approach.
A new approach to the treatment of retinopathies and optic nerve atrophy by using mesenchymal stem cells
Authors: Taralunga Tatiana , Paduca Ala , Nacu Viorel
Published: February 2023

Background: The tissue engineering is the evolving science that combines cells, biomaterials and biochemical factors aimed at restoring, maintaining and substituting different types of tissue. An important role is played by the use of the stem cells in various fields of medicine, including ophthalmology, namely in cases of retinopathies and optic nerve atrophy. Conclusions: Current treatment of the optic nerve atrophy is based on the etiological causes or late complications. Considering the availability of advanced therapies, stem cell therapy offers a new approach in the treatment of the atrophy of the optic nerve. Being easy to harvest and cultivate, mesenchymal stem cells are most commonly used in regenerative medicine, they can be induced to differentiate into cartilage, tendons, adipose tissue and other cell lines. Mesenchymal stem cell harvesting has no ethical issues compared to embryonic stem cell harvesting. The major histocompatibility factor II is not expressed on the surface of mesenchymal stem cells, and this great advantage allows their use in autologous or allogenic form. Mesenchymal stem cells produce growth factors with paracrine action that are thought to activate endogenous repair mechanisms, due to these properties mesenchymal stem cells have been used in several clinical studies in optic nerve disorders where immunomodulatory and neuroprotective properties have been demonstrated. All of the properties mentioned above stand for the clinical use of mesenchymal stem cells in case of optic nerve atrophy.
Analisis Kepatuhan Tenaga Kesehatan Dalam Kelengkapan Pengisian Berkas Rekam Medis di Ruang Penyakit Dalam RSUD Berkah Pandeglang
Authors: Susanto Muhammad Guruh , Windyaningsih Cicilia , Andarusito Nurcahyo
Published: February 2023

RSUD Berkah Pandeglang adalah salah satu lembaga pelayanan kesehatan di Kabupaten Pandeglang yang terus berupaya memberikan pelayanan terbaik kepada masyarakat, dimana penyelenggaraan rekam medis yang baik adalah salah satu kuncinya. Masalah yang sering timbul dalam penyelenggaraan rekam medis adalah dalam proses pengisian berkas yang tidak lengkap, terbukti dari didapatkanya angka tertinggi berkas rekam medis yang tidak lengkap sebesar 17%. Penelitian ini merupakan studi kuantitatif dengan desain studi cross-sectional. Metode kuantitatif dilakukan dengan pengisian kuesioner terhadap responden terhadap Tenaga Kesehatan yang bertugas di Ruang Rawat Inap Penyakit Dalam RSUD Berkah Pandeglang mengenai faktor-faktor yang berhubungan dengan kepatuhan tenaga kesehatan dalam pengisian berkas rekam medis. Seluruh petugas di Ruang Penyakit Dalam RSUD Berkah Pandeglang sikap yang baik, mampu memahami SPO dan bisa berkoordinasi dengan baik dengan unit rekam medis, memiliki pengetahuan yang baik terhadap rekam medis yang terdapat dirumah sakit namun usia dan lama bekerja didapatkan memiliki pengaruh terhadap kelengkapan berkas rekam medis. Pembentukan tim yang berisi petugas senior secara usia maupun lama kerja dengan petugas junior di ruang penyakit dalam khususnya untuk perawat belum dilakukan sehingga terdapat ketidak lengkapan rekam medis yang telah diisi dari ruang penyakit dalam.Kata kunci : Kepatuhan, Rekam Medis, Tenaga Kesehatan
The problem of medical errors in the context of Burnout syndrome
Authors: Pisarenco Constantin , Pisarenco Serghei
Published: February 2023

Purpose. To highlight the significance and trends in solving the problem of medical errors in the context of the burnout syndrome. Materials and methods. With the help of the Google Scholar search engine and the Medline, Web of Science bibliographic databases, according to the key phrases, the literary sources and normative acts related to the studied problem were selected and analyzed. Results. Overstrain and emotional exhaustion of doctors (burnout syndrome) poses a direct risk to patient safety - burned out doctors are much more likely to make mistakes. Identification and analysis of relevant errors can be a step towards their understanding and correction; which, on the one hand, will improve the quality of medical care, and on the other hand, will help doctors deal with the psycho-emotional and legal consequences of medical errors. Conclusions. The burnout syndrome poses a direct risk to patient safety. Prevention of this syndrome improves the quality of medical care, prevents medical errors, their legal and other consequences.
Clinical-imaging features of the institutional cohort of young patients with stroke
Authors: Melnic Adrian , Nacu Gabriela , Cazacu Cristina , Stupac Tatiana , Corcea Galina , Rotaru Lilia , Grosu Oxana
Published: February 2023

Stroke in younger adults is a less common event in comparison to older ones, but there have been registered a negative trend and an earlier onset of stroke in the past decades. Stroke in younger adults represents an emerging public health issue that needs strengthening, prevention, early diagnosis, and management. The aim of the present research is to investigate the clinical features, risk factors and other diagnostic findings of the young population that developed stroke.
Pulmonary thromboembolism in patients with stroke: the results of the clinical-anatomic analysis
Authors: Baitoi Silvia , Grosu Oxana , Rotaru Lilia , Odobescu Stela , Moldovanu Ion
Published: February 2023

Pulmonary embolism is a major cause of mortality in stroke patients and up to 50% of premature deaths in hospitalized patients. The non-specific clinical picture causes diagnostic errors and severely limits the initiation of treatment in atimely manner.The aim of the study was to analyze missed cases of pulmonary embolism in stroke patients treated within the institutional cohort by analyzing the results of morpho pathological examinations. Materials and methods: Retrospective study. Pulmonary thromboembolism was studied as a major cause of death in patients with stroke, hospitalized in the Diomid Gherman Institute of Neurology and Neurosurgery during 2017-2020. 13 patients with a morpho pathologically confirmed diagnosis were included in the study. Results: The study included 5 men (38.5%) and 8 women (61.5%) with an average age of 65±5.2 years. In all patients the diagnosis of stroke was confirmed by CT: ischemic stroke was established in 6 patients (46.8%), hemorrhagic stroke in 4 patients (30.1%), of which 1 patient underwent surgery (7.7%), stroke with hemorrhagic transformation in 3 patients (23.1%). For 11 patients (84.6%) the stroke was primary, and for 2 patients (15.4%) it was repeated. The risk factors were hypertension - 12 patients (92.3%), in 8 patients (61.5%) obesity, diabetes mellitus -5 patients (38.5%), atrial fibrillation in 5 patients (38.5%), 1 patient (7.7%) with thrombosis in other areas. The morpho pathological diagnosis established that pulmonary embolism was the cause of death in all cases, but only 2 (15.4%) patients presented specific symptoms. Conclusion. Stroke patients are at increased risk of pulmonary embolism due to bed rest, limb paralysis and predisposing risk factors, but only a small number of patients are diagnosed in a timely manner, therefore it is important for the clinician to be aware of the severity of the problem and establishing strict prophylaxis and treatment protocols.
Analysis of deaths in the cohort of patients who suffered COVID and neurological manifestations: the results of the energy study in the Republic of Moldova
Authors: Grosu Oxana , Zolotco Galina
Published: February 2023

Several studies have evaluated risk factors associated with mortality related to COVID-19. Important risk factors associated with an increased mortality rate include older age, male sex, current smoking, baseline comorbidities (especially chronic renal, respiratory, and cardio-cerebrovascular disease), dyspnea symptoms, complications during hospitalization, corticosteroid therapy, and a severe condition.The aim of the research was to characterize and analyze the cohort of patients who died with neurological manifestations and COVID 19. Materials and methods: The analysis of the cohort of patients from the Republic of Moldova included in the ENERGY Registry was performed. The Republic of Moldova cohort at the time of publication included 200 patients, who were assessed by telephone every 6 months. 58 patients who died were identified and included in the study. Deaths occurred in both the initial and follow-up phases. Statistical data were extracted and analyzed using SPSS. Results and discussion: The mean age of the patients included in the study group was 70.6 ± 12.1 years. There were 37 women (63.8%) and 21 men (36.2%). The deceased subjects presented comorbidities in 91.4% (53p) cases, being as follows: hypertension (89.7%), coronary heart disease – 29.3% cases, DM type II – 27.6%, renal pathologies (17.2%), liver (6.9%), anemia (6.9%), lung disease (3.4%), presence of cancer – 12.1% and immunosuppression (1.7%). Pre-existing neurological pathologies were present in 44.8% (26 p) of the examined patients, the most important being: stroke (27.6%), dementia (5.2%) and neuropathy (1.7%). 79.3% of patients were admitted to the Intensive Care Unit. Correlation analysis demonstrated a positive correlation between patient death and the presence of diabetes (r=0.163, p=0.034), the presence of any complications (r=0.163, p=0.034), pneumonia (r=0.201, p=0.07) and the need for ventilation support (r=0.206, p=0.007). Conclusions: The cohort of patients who died with COVID 19 and neurological manifestations from the Republic of Moldova has a remarkably high mortality rate (34.3%): patients with comorbidities, pre-existing neurological pathologies, who presented pulmonary complications that required ventilatory support and treatment in intensive care.
Contrasting the impact of two Coronaviridae pandemics in Pakistan
Authors: Mehak Rabail , Ali Syeda Hafsa , Naseem Sadia , Ali Syeda Ayesha
Published: February 2023

SARS-CoV-2 being contagious and highly transmissible emerged in December 2019 causing pandemic of acute respiratory disease. SARS-CoV-2 is highly contagious disease and also named as ‘coronavirus disease 2019’ (COVID-19) as the novel strain identified in 2019. This research review aims to provide an insight to compare important features of SARS with novel COVID-19. We capitulate the current data available on the topic to provide a sound basis on the emerging issues related to two pandemics. Both viruses belong to the same family and accountable for two different pandemics i.e. SARS in 2003 and COVID-19 from 2019 to date. This review focuses on aspects like origin, transmission, pathogenesis, symptoms, impact, and challenges faced during the pandemic, development of immunity, possible treatments, along with possible preventions for personal protection. COVID-19 seems similar to SARS regarding its clinical features and high transmissibility than SARS. Although, COVID-19 belonged to same family as SARS, yet the spread and impact of this disease bought developed and undeveloped countries to their knees. However, the current scenario shows that not only undeveloped countries but also developed countries are not prepared to cope up with pandemic. As soon as the pandemic ends it will enable the world to evaluate the health, social and economic impact of this global mishap and to understand situations according to gained experience most likely in areas of public and global health to prepare for future pandemics.
LOS WAMPIS, EL PRIMER GOBIERNO INDÍGENA AUTÓNOMO EN EL PERÚ: REFLEXIONES Y ENSEÑANZAS PARA LA CRÍTICA LEGAL
Authors: Quiñonez Héctor
Published: February 2023

El presente artículo constituye una revisión al proceso de constitución del Gobierno Territorial Autónomo de la Nación Wampis, pueblo indígena ubicado en la República del Perú, que desde el año 2015 viene luchando por el reconocimiento oficial de su autonomía. A través de la revisión de su estatuto de constitución y de los procesos históricos que motivaron su aprobación, se busca encontrar el fundamento de su decisión a través de la revisión de las categorías del pluralismo jurídico emancipador y de la gobernanza territorial indígena. Se plantea que la constitución del gobierno autónomo wampis propone interesantes herramientas y retos a la crítica jurídica, a través del cuestionamiento y redefinición de los conceptos del Estado nación y de ordenamiento jurídico oficial, además de la necesidad de su seguimiento a través de los procesos de acompañamiento técnico legal. Finalmente, se llama la atención sobre la necesidad de seguir de cerca los procesos de reivindicación autónoma con base en la gestión del territorio que los pueblos indígenas vienen enarbolando en varios países de la región.
Internacionalização, Hospitalidade, Ideologia
Authors: Sá Rubens Lacerda de
Published: February 2023

Na contemporaneidade, o vocábulo mobilidade é metamórfico, múltiplo e sincrético. Esse complexo e intensificado trânsito migratório gera contatos superdiversos, que se refazem na teia social e representam um desafio discursivo a partir da inter-relação daqueles que participam desse processo. Imbricados nesse fluxo de instabilidades do outro e do nós, encontram-se os programas de internacionalização acadêmica. Tais programas são regidos por políticas públicas, educacionais, institucionais e linguísticas, além de guardar relação direta com a globalização moderna. Todos juntos compõem uma gramática própria que é pensada, nesta obra, pela arquitetura do construto ideologia e pelas lentes da plataforma de hospitalidade derridiana. Espero que o desenho deste ensaio possa contribuir para novas discussões sobre essa temática.
Abstract Categorical Logic
Authors: Bloch Isabelle
Published: February 2023

We present in this talk an abstract categorical logic based on an abstraction of quantifier. More precisely, the proposed logic is abstract because no structural constraints are imposed on models (semantics free). By contrast, formulas are inductively defined from an abstraction both of atomic formulas and of quantifiers. In this sense, the proposed approach differs from other works interested in formalizing the notion of abstract logic and of which the closest to our approach are the institutions, which in addition to be semantics free do not also impose any syntactic contingencies on the structure of formulas. To define the semantical framework in which formulas will be interpreted, we propose to follow the idea from categorical logic which defines the semantical interpretation of formulas from context and as subobjects of an object of a given category. In the spirit of Lawvere’s hyperdoctrines, we use a more abstract notion which generalizes the notion of subobject, standard in category theory: Pitt’s prop-categories. Always in the spirit of categorical logic, we propose a sequent calculus of which we show correctness and completeness for all semantical frameworks defined over any prop-categories. We then study some conditions which allow us to get this completeness result for particular classes of prop-categories.
Tổn thương cơ vận nhãn ở bệnh nhân bệnh mắt basedow tại Bệnh viện Mắt Trung ương
Authors: Thị Hương Giang Bùi , Ngọc Đông Phạm , Quốc Tùng Mai
Published: February 2023

Cơ vận nhãn thường bị tổn thương ở bệnh nhân bệnh mắt Basedow (BMB). Tổn thương cơ vận nhãn gây ra nhiều rối loạn lâm sàng, trong đó quan trọng nhất là gây hạn chế vận nhãn (HCVN) và song thị, ảnh hưởng nhiều đến chức năng thị giác, sinh hoạt và lao động. Nghiên cứu mô tả cắt ngang này nhằm đánh giá đặc điểm rối loạn vận nhãn trên 40 bệnh nhân bị BMB có rối loạn vận nhãn từ tháng 8/2021 đến tháng 8/2022 tại Bệnh viện Mắt Trung ương. Kết quả nghiên cứu cho thấy, 70% bệnh nhân có triệu chứng song thị và chủ yếu là song thị đứng với 55%. Bệnh nhân có thể hạn chế vận nhãn (HCVN) một hay nhiều hướng, thường gặp nhất là HCVN lên trên (75%) và lên trên ra ngoài (93,75%), HCVN vào trong ít gặp nhất (25%). Chụp cắt lớp vi tính hốc mắt cho thấy cơ thẳng dưới là cơ hay bị phì đại nhất (72,22%), tiếp đến là cơ thẳng trong (62,96%), cơ thẳng trên (57,41%) và cơ trực ngoài (11,11%).
Gây tê thần kinh đùi và thần kinh hông to đường trước dưới hướng dẫn của siêu âm để giảm đau cho bệnh nhân gãy xương dài chi dưới: Nhân 05 trường hợp đầu tiên
Authors: Đình Lượng Vũ , Hữu Tú Nguyễn , Minh Hải Vũ
Published: February 2023

Gãy xương dài chi dưới là tổn thương nặng, bệnh nhân có nguy cơ sốc do đau. Bệnh viện Đa khoa tỉnh Thái Bình từ tháng 5/2022 đã bắt đầu áp dụng kỹ thuật gây tê thần kinh đùi và thần kinh hông to đường trước bằng levobupivacaine 0,25% dưới hướng dẫn của siêu âm để giảm đau cho bệnh nhân. Quan sát mô tả kết quả của phương pháp này trên 05 bệnh nhân bước đầu cho thấy cả 05 bệnh nhân được giảm đau tốt, điểm đau (VAS) trung bình là 8,6 ± 0,55 giảm xuống 4,2 ± 0,84 sau 5 phút và 3,0 ± 00 sau 10 phút; không có tai biến chứng, không cần thêm thuốc giảm đau khi di chuyển thực hiện các thăm dò cận lâm sàng. Phương pháp gây tê thần kinh đùi và thần kinh hông to đường trước dưới hướng dẫn của siêu âm để giảm đau cho bệnh nhân cấp cứu gãy xương dài chi dưới bước đầu thấy khả thi, an toàn và hiệu quả. Cần nghiên cứu với cỡ mẫu lớn hơn để đánh giá hiệu quả, thuận lợi và khó khăn của kỹ thuật.
Thực trạng chuyển tuyến của người bệnh khoa cấp cứu, hồi sức tích cực, Bệnh viện Đa khoa tỉnh Thanh Hóa, năm 2020
Authors: Thái Sơn Đinh , Văn Sỹ Lê , Văn Cường Lê , Duy Long Lê , Bùi Hải Hoàng
Published: February 2023

Nghiên cứu được thực hiện nhằm mô tả thực trạng chuyển tuyến tại Khoa Cấp cứu, Bệnh viện Đa khoa tỉnh Thanh Hóa năm 2020. Nghiên cứu mô tả cắt ngang đã được thực hiện bằng cách sử dụng dữ liệu từ Phần mềm quản lý bệnh viện tại Khoa Cấp cứu của Bệnh viện Đa khoa tỉnh Thanh Hóa năm 2020. Tổng số 3518 người bệnh nhập viện vào Khoa Cấp cứu, Bệnh viện Đa khoa tỉnh Thanh Hóa đã chuyển tuyến trong năm 2020 được trích suất. Kết quả nghiên cứu cho thấy: Chương bệnh XIX: Chấn thương thương, ngộ độc và hậu quả của một số nguyên nhân từ bên ngoài có tỷ lệ chuyển cao nhất (n = 1388, 39,5%). Đa số người bệnh chuyển từ tuyến dưới lên tuyến trên (n = 2258, chiếm tỷ lệ 64,2%). Số người bệnh chuyển viện trái tuyến chỉ là 89 người (2,5%).
Đặc điểm kháng kháng sinh của enterococcus faecalis kháng fluoroquinolone phân lập từ người, động vật và thực phẩm
Authors: Thị An Hà Hoàng , Vũ Trung Nguyễn , Hà Thanh Nguyễn , Duy Thái Phạm , Thị Lan Hương Nguyễn , Thị Mai Hưng Trần , Huy Hoàng Trần
Published: February 2023

Enterococcus faecalis là tác nhân gây nhiễm trùng cơ hội phổ biến ở bệnh viện và cộng đồng. Sự sẵn có của nó trong nhiều môi trường khác nhau và khả năng đề kháng với nhiều loại kháng sinh đã làm cho vai trò của E. faecalis ngày càng quan trọng hơn. Fluoroquinolone là nhóm kháng sinh được sử dụng rộng rãi trong lâm sàng, đặc biệt là trên bệnh nhân nhiễm trùng đường tiết niệu mà E. faecalis là tác nhân vi khuẩn gram dương gây bệnh thường gặp. Sự tiêu thụ fluoroquinolone trong bệnh viện, trong chăn nuôi đã tạo ra áp lực chọn lọc cho sự đề kháng, theo thực phẩm và sinh vật trung gian, ví dụ như ruồi hoàn toàn có thể đươc lan truyền. 466 chủng E. faecalis từ các mẫu phân người, phân gà, ruồi và thực phẩm chợ được phân lập. Tỷ lệ kháng ciprofloxacin 19,5%, kháng levofloxacin 17,6%. Thử nghiệm tính nhạy cảm của các chủng kháng fluoroquinolone với các kháng sinh khác cho thấy tỷ lệ kháng cao với macrolide, phenicol, tetracylin (> 90%), kháng aminoglycosid mức độ cao (27,5% - 53,9%) và kháng linezolid (63,7%). Nhạy cảm tốt với penicillin và ampicillin. Gen liên quan sự đề kháng là gyrA (có mặt trong 14,4% chủng kháng ciprofloxacin, 18,5% chủng kháng levofloxacin), emeA, ermA, ermB, cat, fexA, tetM, tetL và tetK. 100% chủng kháng linezolid mang optrA, không tìm thấy poxtA. Các gen aac(6′)-Ie/aph(2′′)-Ia, aph(3′)-IIIa, ant(6’)-Ia xuất hiện trong các chủng kháng aminoglycosid mức độ cao. emeA, gen quy định cơ chế kháng bơm đẩy có mặt rộng rãi trên các chủng E. faecalis phân lập được nhưng không có mối liên hệ có ý nghĩa thống kê đối với mức độ kháng fluoroquinolone.
Thực trạng và một số yếu tố ảnh hưởng đến kết quả can thiệp động mạch vành qua da cấp cứu bệnh nhân nhồi máu cơ tim cấp có ST chênh lên tại Bệnh viện Hữu nghị Đa khoa Nghệ An
Authors: Huy Lợi Nguyễn , Mạnh Hùng Phạm , Đình Chỉnh Dương
Published: February 2023

Tái tưới máu sớm phục hồi dòng chảy trong lòng động mạch vành bị tắc nghẽn ở bệnh nhân nhồi máu cơ tim có ST chênh lên (STEMI) là việc tối cấp thiết ảnh hưởng đến chất lượng điều trị và kết cục lâu dài cho bệnh nhân STEMI điều trị tại Bệnh viện Hữu nghị Đa khoa Nghệ An. Chúng tôi tiến hành đề tài nhằm đánh giá thực trạng và một số yếu tố liên quan đến thời gian can thiệp động mạch vành qua da (PCI) ở bệnh nhân STEMI tại Bệnh viện Hữu nghị Đa khoa Nghệ An qua đó cải thiện các quá trình làm chậm trễ thời gian can thiệp cấp cứu. Nghiên cứu mô tả cắt ngang hồi cứu, đối tượng là bệnh nhân STEMI được PCI thì đầu từ 1/2017 - 12/2018 tại Bệnh viện Hữu nghị Đa khoa Nghệ An. Kết quả có 156 bệnh nhân, tuổi trung bình: 69,16 ± 11,56 (năm); nam chiếm 69,2%; thời gian cửa-bóng (D2B): 206,64 ± 124,08 phút; thời gian nằm viện 11,43 ± 41,45 ngày; tỷ lệ tử vong 10,9%. Tỷ lệ tử vong, ngày điều trị, D2B còn khá cao so với các khu vực khác trong nước và quốc tế.
Tác dụng chống xơ gan của vismisco trên mô hình gây xơ gan bằng carbon tetrachloride trên chuột nhắt trắng
Authors: Thị Quỳnh Nhung Bùi , Thị Vân Anh Phạm , Trọng Thông Nguyễn , Ngọc Cương Lương , Phương Thanh Mai
Published: February 2023

Nghiên cứu được tiến hành nhằm đánh giá tác dụng chống xơ gan của sản phẩm Vismisco ở các mức liều 0,6 g/kg/ngày và 1,8 g/kg/ngày trên mô hình thực nghiệm gây xơ gan bằng tiêm màng bụng dung dịch CCl4 liên tục trong 19 tuần trên chuột nhắt trắng chủng Swiss. Các chỉ số đánh giá bao gồm trọng lượng gan tương đối, hoạt độ enzym gan, nồng độ MDA và hydroxyproline trong gan, và mức độ xơ gan trên hình ảnh vi thể. Kết quả nghiên cứu cho thấy Vismisco đã thể hiện tác dụng hạn chế tổn thương xơ hóa gan trên chuột nhắt trắng do CCl4 gây ra như giảm hoạt độ các enzym gan, làm giảm nồng độ bilirubin toàn phần và làm tăng nồng độ albumin và cholesterol toàn phần, làm giảm nồng độ MDA và Hydroxyproline trong dịch đồng thể gan.
Relationship between Burden and Perceived Social Support in Low-income Caregivers
Authors: Chaparro-Diaz Lorena , Carreño-Moreno Sonia Patricia , Alzate Hernández Jeimy Sofía , Acosta-Pardo Camilo Andrés
Published: February 2023

Objectives: To describe and correlate burden and social support in low-income caregivers of chronic patients. Material and methods: A descriptive and cross-sectional study was conducted with 170 low-income family caregivers of people with chronic diseases who answered a survey on sociodemographic and care variables, in addition to the Zarit scale to measure burden and the MOS questionnaire on perceived social support. The analysis was performed using descriptive and differential statistics. Results: Most caregivers were female, and the predominant kinship was father-son. A significant and negative correlation (rs = -.307, p < 0.001) was identified between the caregivers’ burden and perceived social support, as well as a significant and positive correlation (rs = 0.278, p < 0.01) between the time devoted to care and the caregivers’ burden. Conclusions: Low-income family caregivers require more social support to reduce the burden levels.
Plights and Suggestions on the Construction of Social Work Talents in Western China’s Remote Areas
Authors: Qin Yusu , Yuan Lifei , Liu Xiaoqin
Published: February 2023

The days are gone when hard copies of resumes were sent to recruiters and they used to screen and set aside non relevant resumes. Artificial Intelligence has taken up mundane tasks of recruiters by simplifying search algorithms and human computer interaction. Job Boards provide recruiters with a database of candidates powered by a search tool with lot of filters. The demonstration paper actually carries out searches on recruitment database access tools to filter the relevant applicants from a wide pool of data with the help of search engine tools in resume databases of various jobboards. It shows how Boolean operators get through better search results in few minutes. Recruiter job to get to the right candidate is sorted out with Artificial Intelligence so that they can focus more on strategic tasks. Future of AI in recruitment is immense. Already companies are empowering recruiters with 360 degree tools which help with all Human Resource Aspects.
Oxigenación hiperbárica como proceso complementario en la regeneración de la piel en quemadura térmica utilizando hiperoxia con vasoconstricción.
Authors: Rivadeneira Jorge-Elías , Buitrón-Jácome Pablo , Meneses-Salazar Elmer , Yandún-Yalamá Vicente , López Castillo Andrea Poleth
Published: February 2023

Con la Oxigenoterapia Hiperbárica (OHB) se mantiene elevado el oxígeno en los tejidos y en el músculo por más de cuatro horas, aumentando la tensión de oxígeno en los fluidos corporales; mejorando la microcirculación, la actividad fagocítica de los glóbulos blancos; disminuyendo la agregación plaquetaria, la sobrecarga cardiaca; es bacteriostático bactericida y antifúngico, entre otras acciones. El Paciente ha ingresado a Tratamiento de Oxigenación Hiperbárica para tratar quemadura térmica en el 70% del pecho causada por agua hirviendo con quemaduras de 1º y 2º grado en una persona. El objetivo de la investigación fue cicatrizar la herida por quemadura térmica usando hiperoxia con vasoconstricción. El tipo de investigación fue experimental, con diseño Preexperimental. El enfoque de investigación que se usó fue mixto, ya que se realizaron 6 sesiones en cámara hiperbárica combinando productos tópicos y apósitos en un paciente; las técnicas utilizadas son: la observación y entrevista; instrumentos: cámara hiperbárica, oxímetro e historia clínica. Se logra hiperoxia con vasoconstricción y efecto Robin Hood en el periodo de seis semanas, acelerando la velocidad de cicatrización del tejido dérmico. El TOHB acelera la cicatrización y proliferación de células regeneradoras de tejidos epidérmicos con quemadura térmica.
Morphometric Evaluation of Occipital Artery
Authors: ÖZCAN Emrah , DERİNÖZ Esma , KEYİK Bahar , KARACA Ömür , GİRGİN Tuğba , KUŞ İlter , VATANSEVER Alper
Published: February 2023

Objective: Occipital artery anatomy should be well known in order to minimize complications that may occur in the occipital artery, which is closely adjacent to this nerve, during greater occipital nerve blockade. In this study, it is aimed to evaluate the morphometric relationship of the occipital artery with neighboring anatomical structures in order to prevent damage during clinical applications. Materials and Methods: This study was carried out using CTA images of the head and neck region of patients who applied to Balikesir University Medical Faculty Training and Research Hospital for various reasons between 2015 and 2021. In the study, CTA images of 85 individuals aged 35-63 years were evaluated morphometrically using Radiant DICOM viewer 64-bit computer software. The obtained data were transferred to SPSS Version 25 software and analyzed quantitatively. Results: According to the results obtained from the study, no significant difference was found between the variables and genders. As the age of the individual increased, it was observed that the left occipital artery was located more inferolateral to the external occipital protuberance. As a result of the data obtained, a negative correlation was observed between the closest distance between the right OA-ML and the right EOP-ML and the spinous process of the seventh cervical vertebra. Conclusion: In line with the average values obtained as a result, it is thought that an injection to the central point of the triangular area, which is formed as a result of combining the reference points in the posterior occiput, may be safer in order to protect the occipital artery.
Evolution of Mechanical Properties of an AA 6061 T6 Aluminum alloy Processed by Cold Working (CW)
Authors: ALİ Debıh
Published: February 2023

Nano scale grain size reduction (UFG) is one of three suitable methods for improving the mechanical properties of 6000 series aluminum alloys, by structural precipitation, strain hardening or by cold work hardening. For the cold working, several techniques are now available such as (ECAP - PC), (CEEA), (THP), (MM), (ARB), (CW). Cold work by compression high pressing (CW-CHP) can be applied in several cycles depending on the hardening behavior of the material. The influence of the nonmetric size of the grains produced by the (CW-CHP) of a cylindrical rolling machine with four passes of Sever plastic deformation with reduction ratios of (3.5, 10,18.8 and 28%), on the mechanical behavior of the alloy 6061 T6, was analyzed by determining the ultimate tensile strength (Rm), yield strength (Rp0.2, the strain hardening capacity SHC (Rm-Rp0.2), the work hardening coefficient n', the modulus of 'work hardening K' . The increase in the rate of work hardening by the reduction of the sample sections and consequently the reduction of the grain size at the first and the second pass, improves the mechanical properties of the alloy to the maximum values, and then the presence of crack initiation participates to the moderate decrease of the mechanical properties.
DHAKA WATER SUPPLY SYSTEM MANAGEMENT DEVELOPS A MODEL OF URBAN DRAINAGE OPRATION AND MAINTENANCE PROJECT WITH SOFTWARE TECHNOLOGY
Authors: Farok Dr. Engr. Gazi , Vries Taco De , Ullah Shahid
Published: February 2023

Dhaka Water Supply System Management (i.e.; Dhaka WASA) is the main service provider in drainage system maintenance in Dhaka city. In the mega-city of Dhaka the capital of Bangladesh, with over 10 million people facing acute problems in increasing urban flooding, storm sewrage and sanitation which affecting millions of inhabitants and businesses every year. To remedy these urban flooding problems the responsible authority, (DWASA) has started the Urban Dredging Demonstration Project (UDDP) under the existing partnership with Vitens Evides International from the Netherlands. Once Dhaka city has 49 canals which served as the natural drainage system but with the course of time most of canals are illegally occupied and disappeared and rest of them have become narrower, silted up, and blocked. To overcome this problems adoption of new dredging tecnology and longterm dredging plan with WIT (sediment information system) offers a solution. WIT is a dynamic web-based GIS application for planning and maintenance operations of drainage system. It offers a unique combination of tools which makes it possible to process data and prepare long-term dredging plans. Practical modules allow for the optimisation of maintenance dredging by calculating quantities dredged material, the testing of data quality and planning of maintenance dredging. The data can be visualized in tables, diagrams, charts for invsetgating the following questions: location of dredged waterways, volume of sediment (material) to be dredged, quality (chemical and physical) of the dredged materials, total costs of the dredging operations and maintenance, available sites for disposal.
EXAMINING EFFECT OF FORWARD INTEGRATION CREDIT RISK MITIGATION MECHANISMS ON RETURN ON EQUITY (ROE) OF AGRIBUSINESS FIRMS IN KENYA
Authors: Owuor Ombok Benjamin
Published: February 2023

Commercial Banks apply Forward Integration Credit Risk Mitigation Mechanisms (FICRMMs) to promote credit access, security and productivity for various sectors, since credits make a significant portion in business’ capital structure and performance. Credits to the agribusiness sector; which contributes 53% to employment in developing countries, and 80% in Kenya, has registered decreasing trends between 2002 and 2016; ranging from 6.5% to 2.9%. However, there is little information on the effect of Forward Integration Credit Risk Mitigation Mechanisms on agribusiness firms’ performance with respect to Equity as owner investments in Agribusiness Enterprises in Nyanza region; where agribusiness operations play core absorption over 80% of its labour-force. The purpose of this study was to analyse the effect of Forward Integration Credit Risk Mitigation Mechanisms on Return on Equity (ROE) of agribusinesses enterprises. With objectives of determining the effect of the mechanisms on ROE, the single period Regression results reveal R2 of 0. 647 to return on equity (ROE), implying that FICRMMs account for 57% of ROE at significant level p<0.05.
EFFECT OF REWARD AND PERFORMANCE MANAGEMENT ON EMPLOYEE PRODUCTIVITY: A STUDY OF SELECTED LARGE ORGANIZATIONS IN THE SOUTH-EAST, OF NIGERIA
Authors: Phina Onyekwelu Njideka , Arinze Anah Stanley , Chukwuma Ejike Daniel
Published: February 2023

This study examined the effect of reward and performance management on employee productivity in an organization. It is a study of large private sector organizations selected from some states of the South-East, Nigeria. As a descriptive survey design, a sample of 336 was determined from the population of 2081 senior employees of Serbmilla Industries, Onitsha, Nigeria Breweries PLC Ama-Enugu and Nigeria Bottling Company, Irrete, Owerri, Imo-State. Units of Observation (Sampling points) were selected through the method of systematic sampling. Out of the 336 copies of the questionnaire distributed, 321 were completed and returned thus showing a response rate of 95.5 percent which we considered very adequate. Through the application of Chi-Square (χ2) inferential statistics, pearson product moment correlation coefficient and t-test for significance of ‘r’, as the tools of analysis, the result showed that task autonomy significantly affects employee productivity. Also, the analysis revealed that task involvement influences job satisfaction and productivity. It was equally found from the analysis of data that tasks significance and employee empowerment enhances employee performance in the organization. It was concluded that empowered organizational climate would help to create a pool of committed and selfmotivated individuals with visions, creativity, innovation and technical powers to convert the threat of change into opportunities for business growth and development. It was recommended among others that the management should try to create an environment conducive for maximum utilization of employees’ skills, competencies creativity and talents for the benefit of all stakeholders in the organization.
BUILDING INCLUSIVE DIGITAL SOCIETIES THROUGH THE USE OF OPEN SOURCE TECHNOLOGIES
Authors: Turkama Petra
Published: February 2023

Digital convergence offers many new opportunities, but also poses architectural and structural issues. One of the most critical obstacles is the ‘vertical silos model’ that shapes much of today’s Internet. The accumulation of money, power and influence create further concern. We propose the use of open source technologies as a partial solution for the identified challenge. These technologies enable scalability of innovations and drive distribution wealth. Open source technologies have been studied extensively from technical view point, but less from adaptation side. Our research took customer view in technology sourcing. Data was collected in a survey and interviews with 120 companies in Europe. The enquiry revealed that open source technology adaptations were limited due to the uncertainties related to sustainability of communities, SLAs and regulations. The study implied that the industry needs to evolve toward increased customer orientation. The study contributes to adaptation of open source technologies.