bluuebunny/crossref_metadata_2025 huggingface dataset:
Trends of Two Epidemic Multidrug-Resistant Strains of Mycobacterium tuberculosis in Argentina Disclosed by Tailored Molecular Strategy
Authors: Monteserin Johana , Pérez-Lago Laura , Yokobori Noemí , Paul Roxana , Rodríguez Maus Sandra , Simboli Norberto , Eldholm Vegard , López Beatriz , García de Viedma Darío , Ritacco Viviana
Published: October 2019

Two Mycobacterium tuberculosis strains—M (sublineage 4.1) and Ra (sublineage 4.3)—have long prevailed in Argentina among patients with multidrug-resistant tuberculosis (MDR-TB). Recently, budget constraints have hampered the surveillance of MDR-TB transmission. Based on whole-genome sequence analysis, we used M- and Ra-specific single nucleotide polymorphisms to tailor two multiplex allele-specific polymerase chain reactions (PCRs), which we applied to 252 stored isolates (95% of all newly diagnosed MDR-TB cases countrywide, 2015–2017). Compared with the latest data available (2007–2009), the M strain has receded (80/324 to 20/252, P < 0.0001), particularly among cross-border migrants (12/58 to 0/53, P = 0.0003) and HIV-infected people (30/97 to 7/74, P = 0.0007), but it still accounts for 4/12 new cases of extensively drug-resistant TB. Differently, the Ra strain remained stable in frequency (39/324 to 33/252) and contributed marginally to the extensive drug-resistance load (1/12). Our novel strategy disclosed recent trends of the two major MDR-TB strains, providing meaningful data to allocate control interventions more efficiently.
Seamless, 304/304L Stainless Steel Tubing
Authors:   Metallic Tubing Committee
Published: October 2019

This SAE Standard covers seamless stainless steel pressure tubing intended for use as hydraulic lines and in other applications requiring corrosion resistance.
High Strength, 304/304L Stainless Steel Tubing
Authors:   Metallic Tubing Committee
Published: October 2019

This SAE standard covers both “welded and cold drawn” and “seamless” stainless steel pressure tubing in the as-cold-drawn high strength condition intended for use as high pressure hydraulic lines and other applications requiring corrosion resistance. Welding, brazing, or other thermal processing methods that subject the tube material or assembly to elevated temperatures may compromise the strength of the tubing.
The control of hydrogen sulfide on benthic iron and cadmium fluxes in the oxygen minimum zone off Peru
Authors: Plass Anna , Schlosser Christian , Sommer Stefan , Dale Andrew W. , Achterberg Eric P. , Scholz Florian
Published: October 2019

Abstract. Sediments in oxygen-depleted marine environments can be an important sink or source of bio-essential trace metals in the ocean. However, the key mechanisms controlling the release from or burial of trace metals in sediments are not exactly understood. Here, we investigate the benthic biogeochemical cycling of Fe and Cd in the oxygen minimum zone off Peru. We combine bottom water profiles, pore water profiles, as well as benthic fluxes determined from pore water profiles and in-situ from benthic chamber incubations along a depth transect at 12° S. In agreement with previous studies, both concentration-depth profiles and in-situ benthic fluxes indicate a Fe release from sediments into bottom waters. Diffusive Fe fluxes and Fe fluxes from benthic chamber incubations are roughly consistent (0.3–17.1 mmol m−2 y−1), indicating that diffusion is the main transport mechanism of dissolved Fe across the sediment-water interface. The occurrence of mats of sulfur oxidizing bacteria on the seafloor represents an important control on the spatial distribution of Fe fluxes by regulating hydrogen sulfide (H2S) concentrations and, potentially, Fe sulfide precipitation within the surface sediment. Removal of dissolved Fe after its release to anoxic bottom waters is rapid in the first 4 m away from the seafloor (half-life
Uncertainty in regional estimates of capacity for carbon capture and storage
Authors: Wilkinson Mark , Polson Debbie
Published: October 2019

Abstract. Carbon capture and storage (CCS) is a potentially important
technology for the mitigation of industrial CO2 emissions. However, the
majority of the subsurface storage capacity is in saline aquifers, for which
there is relatively little information. Published estimates of the potential
storage capacity of such formations, based on limited data, often give no
indication of the uncertainty, despite there being substantial uncertainty
associated with the data used to calculate such estimates. Here, we test the
hypothesis that the uncertainty in such estimates is a significant
proportion of the estimated storage capacity, and should hence be evaluated
as a part of any assessment. Using only publicly available data, a group of
13 experts independently estimated the storage capacity of seven regional saline
aquifers. The experts produced a wide range of estimates for each aquifer
due to a combination of using different published values for some variables
and differences in their judgements of the aquifer properties such as area
and thickness. The range of storage estimates produced by the experts shows
that there is significant uncertainty in such estimates; in particular, the
experts' range does not capture the highest possible capacity estimates.
This means that by not accounting for uncertainty, such regional estimates
may underestimate the true storage capacity. The result is applicable to
single values of storage capacity of regional potential but not to detailed
studies of a single storage site.
Aerogeophysical characterization of an active subglacial lake system in the David Glacier catchment, Antarctica
Authors: Lindzey Laura E. , Beem Lucas H. , Young Duncan A. , Quartini Enrica , Blankenship Donald D. , Lee Choon-Ki , Lee Won Sang , Lee Jong Ik , Lee Joohan
Published: October 2019

Abstract. In the 2016–2017 austral summer, the University of Texas Institute for Geophysics (UTIG) and the Korea Polar Research Institute (KOPRI) collaborated to perform a helicopter-based radar and laser altimeter survey of lower David Glacier with the goals of characterizing the subglacial water distribution that supports a system of active subglacial lakes and informing the site selection for a potential subglacial access drilling project. This survey overlaps with and expands upon an earlier survey of the Drygalski Ice Tongue and the David Glacier grounding zone from 2011 and 2012 to create a 5 km resolution survey extending 200 km upstream from the grounding zone. The surveyed region covers two active subglacial lakes and includes re-flights of ICESat ground tracks that extend the surface elevation record in the region. While this is not the first aerogeophysical survey of an active lake system, it is one of the most extensive, and provides higher resolution boundary conditions and basal characterizations that will enable process studies of these features. This paper introduces a new helicopter-mounted ice-penetrating radar and laser altimetry system; notes a discrepancy between the original surface-elevation-derived lake outlines and locations of possible water collection based on basal geometry and hydraulic potential; and presents radar- based observations of basal conditions that are inconsistent with large collections of ponded water, despite laser altimetry showing that the hypothesized active lakes are at a high-stand.
Gerenciamento de resíduos sólidos na atenção primária à saúde
Authors: Silva Joice Teles da , Almeida Talita Hevilyn Ramos da Cruz , Silva Myria Ribeiro da , Azevedo Alana Do Nascimento , Ferreira Sonia Maria Isabel Lopes , Silva Gisleide Lima , Monteiro Nayara Mary Andrade Teles
Published: October 2019

Objetivo: analisar o gerenciamento dos resíduos sólidos da Atenção Primária à Saúde. Método: trata-se de um estudo qualitativo, descritivo, exploratório, observacional. Observaram-se nove das dez Unidades Saúde da Família da Atenção Primária à Saúde. Utilizou-se, como técnica de coleta de dados, a observação não participante por meio de um roteiro. Empregou-se, para tratamento e análise dos dados, a análise descritiva. Resultados: apontou-se que o gerenciamento dos resíduos sólidos na APS do município em questão não está em conformidade com a legislação brasileira. Conclusão: torna-se imprescindível que haja ações de educação permanente sobre o gerenciamento dos resíduos com o intuito de que os enfermeiros e sua equipe sejam instrumentalizados a elaborar e implementar, com eficiência, o PGRSS. Descritores: Resíduos Sólidos; Enfermagem; Atenção Primária à Saúde; Saúde e Meio Ambiente; Infecção; Controle de Doença.AbstractObjective: to analyze the management of solid waste from Primary Health Care. Method: this is a qualitative, descriptive, exploratory, observational study. Nine of the ten Family Health Units of Primary Health Care were observed. Non-participant observation was used as a data collection technique through a script. For data treatment and analysis, descriptive analysis was used. Results: it was pointed out that the solid waste management in the PHC of the municipality in question is not in accordance with the Brazilian legislation. Conclusion: it is essential that there are permanent education actions on waste management in order to enable nurses and their staff to be instrumental in effectively designing and implementing the PGRSS. Descriptors: Solid Waste; Nursing; Primary Health Care; Health and Environment; Infection; Disease Control.ResumenObjetivo: analizar el manejo de residuos sólidos de la Atención Primaria de Salud. Método: estudio cualitativo, descriptivo, exploratorio, observacional. Se observaron nueve de las diez Unidades de Salud Familiar de Atención Primaria de Salud. Se utilizó como técnica de recolección de datos a través de un guión. Para el tratamiento y análisis de datos, se utilizó un análisis descriptivo. Resultados: se señaló que la gestión de residuos sólidos en la APS del municipio en cuestión no se ajusta a la legislación brasileña. Conclusión: es esencial que existan acciones educativas permanentes sobre gestión de residuos para que los enfermeros y su personal puedan desempeñar un papel decisivo en el diseño y la implementación eficaces de los PGRSS. Descriptores: Residuos Sólidos; Enfermería; Atención Primaria a la Salud; Salud y Medio Ambiente; Infección; Control de Enfermedad.
Variational analysis for some frictional contact problems
Authors: Ait Kaki Leila , Denche M.
Published: October 2019

We consider a class of evolutionary variational problems which describes the static frictional contact between a piezoelectric body and a conductive obstacle. The formulation is in a form of coupled system involving the displacement and electric potentiel fieelds. We provide the existence of unique weak solution of the problems. The proof is based on the evolutionary variational inequalities and Banach's xed point theorem.
Tripartite graphs with energy aggregation
Authors: Alawn Nawras A. , Al-Saidi Nadia M. G. , Rasheed Rashed T.
Published: October 2019

The aggregate of the absolute values of the graph eigenvalues is called the energy of a graph. It is used to approximate the total _-electron energy of molecules. Thus, finding a new mechanism to calculate the total energy of some graphs is a challenge; it has received a lot of research attention. We study the eigenvalues of a complete tripartite graph Ti,i,n−2i , for n _ 4, based on the adjacency, Laplacian, and signless Laplacian matrices. In terms of the degree sequence, the extreme eigenvalues of the irregular graphs energy are found to characterize the component with the maximum energy. The chemical HMO approach is particularly successful in the case of the total _-electron energy. We showed that some chemical components are equienergetic with the tripartite graph. This discovering helps easily to derive the HMO for most of these components despite their different structures.
On (f, I) - Lacunary statistical convergence of Order α of sequences of sets
Authors: Sengul Hacer , Et Mikail , Cakalli Huseyin
Published: October 2019

In this paper we introduce the concepts of Wijsman $% \left( f,I\right) -$lacunary statistical{\Large \ }convergence of order $% \alpha $ and Wijsman strongly $\left( f,I\right) -$lacunary statistical% {\Large \ }convergence of order $\alpha ,$ and investigated between their relationship.
Normality and quotient in the category of crossed modules within the category of groups with operations
Authors: Şahan Tunçar , Mucuk Osman
Published: October 2019

In this paper we define the notions of normal subcrossed module and quotient crossed module within groups with operations; and then give same properties of such crossed modules in groups with operations.
The Effects of Corporate Governance, Corporate Social Responsibility, and Intellectual Capital Disclosure on the Sustainability of Banking Sector in Bangladesh
Authors: Ahmed Nisar , Abedin Md. Joynal
Published: October 2019

Sustainability is one of the most cornering issues for the current corporate world. Wide realization has been adapted by the major organizations where everybody endorses to do business in a long run, not just to maximizing the profit. Aiming to create better environment for the future generations, several steps has been taken by various local and international associations and bodies. The focus areas that ensure sustainable practice are intellectual capital disclosure, CSR expenditure, infrastructural asset, research and development expenses, corporate governance structure, green banking policy, financial development, environmental effects and many other factors. Firms are aware of maintaining these factors effectively to sustain in the market. Sustainability is a massive subject and various component are related with this major issue. Recently three of the components such as Corporate Governance, Corporate Social Responsibility and Intellectual Capital Disclosure has grabbed the major attention and maintained with an important manner. Private commercial banking sector is one of the most popular and growing sectors in Bangladesh. Due to high competition, to sustain in the market is difficult for those banks. As a turn out various components of sustainability are effectively maintained by the banks. This paper shows how CG, CSR and ICD affect the sustainable practice of the private commercial banking sector in Bangladesh. It also relates various components and shows ways to improve the sustainable practice in our current situation.
EFL Learners’ English Speaking Difficulties and Strategy Use
Authors: Shen Ming-yueh , Chiu Tzu-yen
Published: October 2019

This study aimed to explore the factors that caused the EFL learners’ English speaking difficulties and then investigate the successful learners’ strategy use to improve their English speaking performance. A five-level Likert-scale questionnaire was conducted to anonymously investigate 148 EFL sophomore and junior English majors in Taiwan. Results of the analysis showed that (a) psychological problems (e.g. nervousness, fear of making mistakes, and lack of confidence) was the primary reason for English speaking difficulties, followed by linguistic problems (e.g. insufficient vocabulary), and environmental problems (e.g. lack of learning context for English conversation); (b) a majority of successful learners tended to use various speaking strategies to improve their English speaking performance and particularly focused on linguistic accuracy by repeatedly practicing the pitch, pronunciation, and intonation. Furthermore, most of them seized the chances to practice speaking English, such as joining English social activities, or participating in English speech contests etc. They also used the body language (e.g. facial expressions, eye contacts, and gestures) for better communication. The findings suggest pedagogical implications for promoting the EFL learners’ speaking English.
Verbal Reduplication in the Omani Dialect
Authors: Al Jahdhami Said
Published: October 2019

Omani Arabic exhibits an exotic morphological process that fully reduplicates CVC monosyllabic structures into CVC.CVC verbal structures. Over four hundred verbs are formed via full reduplication of CVC structures that results into intransitive and transitive verbs as well as those that fall into both categories. A substantial number of these CVC structures do not really have meanings in isolation; when reduplicated, however, they form verbs that generally express repetition of an action and/or have a negative element associated with them. The reduplication process does not only give these verbs their meanings, but it also gives them their repetitive or negative component. Interestingly, partial reduplication of the rhyme of these CVC structures conjoined with C2 gemination (i.e. C1V1C2.C2V1C2) that makes C2 the onset and coda of the second syllable yields three types of verbal structures: those that express the same meanings as those fully reduplicated structures, those that have completely different meanings from their fully reduplicated counterparts, and those that are meaningless. Metathesis of the two consonants in these CVC structures (i.e. C2V1C1. C2V1C1 instead of C1V1C2.C1V1C2) results in meanings similar to those of the original forms in some cases as well as in completely different meanings in the majority of these verbal structures.
La programación de contenido intercultural de TV MICC y su incidencia en el fortalecimiento de la identidad cultural de los jóvenes del pueblo panzaleo de la provincia de Cotopaxi, república del Ecuador, 2017-2018
Authors: Ugsha Toaquiza Celso Germán , Yantalema Caín Alfonso Bolívar
Published: October 2019

Esta investigación analiza ocho programas de contenido intercultural difundida a través del único canal de ámbito nacional, de tipo comunitario Tv Micc 47 de propiedad del Movimiento Indígena y Campesino de Cotopaxi (MICC) y la manera cómo incide dicha programación en el fortalecimiento de la identidad cultural de los jóvenes del pueblo panzaleo de Cotopaxi, mediante la aplicación de encuestas a una muestra aleatoria de 332 estudiantes indígenas de bachillerato de los cantones de Latacunga, Saquisilí y Salcedo. Para este proceso se aplicó la metodología de investigación desarrollada por la Pluriversidad Amawtay Wasi, que implicó la socialización del proyecto a dirigentes organizacionales, equipo técnico del canal y autoridades educativas; la aplicación de encuestas; la tabulación, análisis, interpretación y sistematización de los resultados apoyados con gráficos estadísticos. De la presente investigación se verificó que los programas más sintonizados de TV MICC 47 son “El sentimiento andino dominical” (41,3%), “Por los caminos de la danza” (29,3%), el noticiero “Voces e identidad” (14,3%) y “Ñukanchik yuyay” (11,3%); que por sus contenidos musicales, dancísticos, informativos y de opinión, con la participación de actores locales y externos, logran incidir en las opiniones de los jóvenes panzaleo alcanzando una aceptación significativa del 75,7% respecto a las expresiones identitarias del kichwa, de la vestimenta y alimentación propias. Con base a la preferencia hacia programas de entretenimiento, surge la necesidad de innovar la programación de contenido intercultural con otros formatos comunicativos como el teleteatro, la animación digital, incluyendo como presentadores a los jóvenes con sus propias estéticas.
Museos Comunitarios como una Estrategia de Comunicación Intercultural Ancestral en Nueva Guinea, RACCS
Authors: Sobalbarro Pao Greyci , Zapata Webb Yuri Hamed
Published: October 2019

La cosecha confirma que el Museo Comunitario “Los Ranchitos”, es una estrategia de comunicación intercultural ancestral en Nueva Guinea, que aporta notablemente a la herencia cultural y a la revitalización de la identidad colectiva del pueblo mestizo. También, fortalece la Red Nicaragüense de Museos Comunitarios. Consistentemente, el estudio permite documentar el trabajo que desde el territorio se emprende para el rescate del patrimonio cultural. Este es un estudio cualitativo, guiado por “el camino de Creación, Recreación de Conocimientos, Saberes y Prácticas de URACCAN”, en una estrategia que aseguró el involucramiento directo de la comunidad articulada desde la red nicaragüense de museos comunitarios y el comité amigos del museo. El estudio destaca que si bien estos espacios son un instrumento para la protección y preservación del patrimonio cultural y la identidad del pueblo mestizo de Nueva Guinea, hace falta mayor divulgación, creación de conciencia y cuido en su calidad de sitios ancestrales.
De Urgenda-zaak en de mogelijkheden voor internationale rechtspraak door de Nederlandse rechter in algemeen-belangacties
Authors: Kuiper-Slendebroek B.A.
Published: October 2019

De Urgenda-zaak en de mogelijkheden voor internationale rechtspraak door de Nederlandse rechter in algemeen-belangacties

Met de Urgenda-zaak is niet alleen de dialoog geopend over de betekenis van het internationale klimaatrecht, de mogelijkheden voor algemeen-belangacties op andere gebieden en de verhouding tussen de Nederlandse staatsmachten, maar komt ook de rol van de nationale rechter in het internationale recht aan bod. Via de route van het EVRM wijst de Nederlandse rechter de Staat op zijn internationale verplichtingen – waaronder die van de positieve bescherming van mensenrechten – en brengt hij de rechtsopvattingen van internationaal en nationaal recht op één lijn. Dit getuigt van een actieve rol van de rechter. Geplaatst in het licht van internationale ontwikkelingen en het Rookverbod-arrest biedt deze rol ook mogelijkheden voor algemeen-belangacties wanneer de normen uit internationale verdragen in het concrete geval rechtstreeks toegepast kunnen worden door de rechter.
Age, origin and tectonic setting of Dulaankhan granitic pluton in northern Mongolia
Authors: Gendenjamts Baatar , Munkhtsengel Baatar , Odgerel Dashdorjgochoo , Sanchir Dorjgochoo , Ganbat Bayaraa
Published: October 2019

Dulaankhan granitic pluton, which is situated in northern Mongolia, the southern portion of the Mongolian-Transbaikalian belt (MTB), is petrographically composed of fine to medium-grained peralkaline granite and is intruded by a small body of quartz syenite. Geochemical data show the Dulaankhan granite and the intruding quartz syenite are both slightly peraluminous and high-K calc-alkaline, and are enriched in LREEs relative to the HREEs, with negative Eu anomaly, and in large ion lithophile elements (LILEs; such as K, Cs and Rb) with respect to high field strength elements (HFSEs; e.g., Nb, Ta and Ti). In terms of relations of Nb, Zr and Y to Ga/Al, however, the Dulaankhan granite and quartz syenite show geochemical features of A-type granites and can be classified into the A2-sub type granite, implying that the pluton formed in an post-collision extensional environment. LA-ICPMS zircon U-Pb dating results suggest that the Dulaankhan granite crystallized at 198±1 Ma, whereas the intruding quartz syenite at 180±1 Ma, consistent with our field observation that the quartz syenite intrudes the granite, attesting that the two granitic bodies were emplaced at different times although both of them formed during the Early Jurassic period. According to these new data, as well as regional ones, we propose that the Dulaankhan granitic pluton was likely generated in the post-collision setting related to the orogenesis of the Mongol-Okhotsk belt that seems to occur prior to Early Jurassic in the northern Mongolian segment.
The Linkage Between Intangible Resources and Export Performance: the Mediating Effect of Innovation
Authors: Rua Orlando Lima , França Alexandra
Published: October 2019

This paper develops a framework to test the relationship between intangible resources and export performance, considering the mediating effect of innovation. Based on survey data from Portuguese small and medium-sized enterprises (SMEs) exporting footwear findings suggest that: (1) innovation has a direct and positive influence on export performance; and (2) innovation does have a mediating effect on the relationship between intangible resources and export performance. This study deepens our understanding and provides novel insights into strategic management literature, since it combines multiple factors and has obtained the importance of each construct in SMEs business growth.
Sozialpolitik für die Soziale Arbeit
Authors: Fehmel Thilo
Published: October 2019

This volume provides an introduction to social policy and the system of social protection in Germany, focusing in particular on social work as a part of social policy. It explains the fundamental societal mechanisms of redistribution and social security, discusses welfare state theories and presents the development of German social policy. It focuses on providing a detailed description of the structure of the German welfare state, discussing both the different welfare state pillars (social insurance, social compensation, social assistance and social support) as well as the various levels of sociopolitical institutions. It also hones in on recent social policy developments (the transformation of welfare production) in terms of their respective significance for social work as a discipline and a profession.
Die Verfassung der Jakobiner von 1793 und ihr historischer Kontext
Authors: Heyer Andreas
Published: October 2019

On 10 August 1793, the French nation celebrated the adoption of the Constitution by the people in a gigantic procession. The Constitution of 1793 was not only an attempt to codify the status quo and the achievements of the Revolution, to cast it into a solid and fundamental form, to create a foundation on which to continue developing. It was also a reaction to the present, to the crises and catastrophes, to the internal and external war instigated by the bourgeoisie (the Gironde) and to the capitalist gifts bestowed on the poor and disenfranchised: hunger, need, misery and despair. Last but not least, the Constitution was the result of numerous debates and discussions, but above all of a multifaceted compromise.
The democratic and emancipatory ideas of the Jacobin Constitution of 1793 have never again been achieved or implemented in any constituent society. Is this one of the reasons why the Jacobins around Robespierre are mostly demonised and reduced to the terror they supposedly created, in order to discredit the memory of their political visions and their humanist heritage?
Strafrecht Allgemeiner Teil
Authors: Kindhäuser Urs , Zimmermann Till
Published: October 2019

Der Allgemeine Teil des Strafrechts zählt wegen seines hohen Abstraktionsgrades und der nahezu unüberschaubaren Zahl von Meinungsstreitigkeiten zu den komplexesten und kompliziertesten Materien in der juristischen Ausbildung. Die Neuauflage des Lehrbuchs von Kindhäuser bringt die ausbildungsrelevanten Themenbereiche verständlich, komprimiert und leserfreundlich strukturiert nahe. Es eignet sich sowohl zur ersten Einführung in den Allgemeinen Teil des Strafrechts als auch zur Wiederholung des Stoffes.
Neu hinzugetreten in die Autorenschaft ist Herr Professor Till Zimmermann.
Listening to the Salmon
Authors: Kuperus Gerard ,   International Association for Environmental Philosophy
Published: October 2019

When salmon disappear, their loss is felt among many species of animals, trees, and plants. This essay suggests listening to the salmon when it comes to learning how to become better members of the earth community, so that not our presence, but our absence would be a loss to the ecosystems that we dwell in. This argument is made through a discussion of Latour’s Facing Gaia and the Native American philosophy of the Tlingit. Albeit in different terms, both suggest ways to become better participants in a greater unity.
Cynic Philosophical Humor as Exposure of Incongruity
Authors: Turner Christopher ,   Philosophy Documentation Center
Published: October 2019

I examine several recent interpretations of Cynic philosophy. Next, I offer my own reading, which draws on Schopenhauer’s Incongruity Theory of Humor, Aristotle’s account of the emotions in the Rhetoric, and the work of Theodor Adorno. I argue that Cynic humor is the deliberate exposure of incongruities between what a thing or state of affairs is supposed to be (either by nature or according to tradition) and what it in fact is, as evidenced by its present manifestation to our sense-perception and thought. Finally, I interpret the significance of this new reading: the exposure of incongruity aims to elicit a response of righteous indignation at the failure of phenomena to live up to our reasonable expectations. Cynic humor redeems the value of ‘wrong life’ by rendering its wrongness palpable and thus intolerable, by availing itself of reason’s inability to withstand flagrant contradictions.
Divine Hiddenness and the Concept of God
Authors: Di Ceglie Roberto ,   Philosophy Documentation Center
Published: October 2019

John Schellenberg’s version of the divine hiddenness argument is based on a concept of God as an omnipotent, morally perfect, and ontologically perfect being. I show that Schellenberg develops his argument in a way that is inconsistent with each of these aspects, from which it follows that the argument in question proves to be unsustainable.
How Lewis Can Meet the Integration Challenge
Authors: Fischer Bob , Gilbertson Eric ,   Philosophy Documentation Center
Published: October 2019

We show that Lewis’s modal realism, and his serviceability-based argument for it, cohere with his epistemological contextualism. Modal realism explains why serviceability-based reasoning in metaphysics might be reliable, while Lewis’s contextualism explains why Lewis can properly ignore the possibility that serviceability isn’t reliable, at least when doing metaphysics. This is because Lewis’s contextualism includes a commitment to a kind of pragmatic encroachment, so that whether a subject knows can depend on how much is at stake with respect to whether the belief is true or false. Accordingly, we suggest that Lewis can count as knowing that serviceability is a reliable guide to truth in metaphysics, since the stakes are generally low there, and so can be justified in believing that modal realism is true based on its serviceability.
Influência das variáveis meteorológicas na saúde: análise das internações por pneumonia em crianças
Authors: Xavier Juliana Meira de Vasconcelos , Souza Patricio Marques de , Silva Fabrício Daniel dos Santos , Olinda Ricardo Alves de , Querino Luana Andrade Lima
Published: October 2019

Existe uma prevalência nos registros hospitalares por doenças respiratórias, em especial nas crianças. A pneumonia é uma das morbidades respiratórias com maiores registros de morbimortalidade no Brasil e no município em estudo. Objetivou-se com esta pesquisa analisar a influência das variáveis meteorológicas nas internações por pneumonia em crianças. A atual pesquisa se trata de um estudo epidemiológico, descritivo de corte transversal com abordagem quantitativa e descritiva. Para a análise estatística dos dados foi ajustado o modelo binomial negativo pertencente à classe dos modelos lineares generalizados, adotando-se um nível de significância de 5%, com base na plataforma estatística R.  Estimou-se que o número médio de casos de pneumonia aumente aproximadamente 48 % a cada grau centígrado de aumento da temperatura média do ar e diminua aproximadamente 32% a cada grau centígrado de aumento da temperatura máxima do ar, diminuindo também em torno de 3% a cada 1% de aumento acima da média da umidade relativa, em relação a variável vento espera-se que o número de casos de pneumonia aumente em torno de 36% com o aumento na velocidade do vento. Avaliar o risco para a saúde da população em razão dos dados climáticos é um passo importante para o planejamento e a implementação de ações. Os gestores da saúde pública podem utilizar o modelo de previsão para preparar os serviços de saúde para receber crianças em períodos em que ocorrem maiores registros de casos de pneumonia.
Dos direcciones de un mismo camino: el hispanoamericanismo cultural de José María Chacón y Calvo.
Authors: Guillama Camba Ruxandra
Published: October 2019

Este trabajo tiene el propósito de contribuir a renovar el enfoque ofrecido hasta el momento sobre el hispanoamericanismo en José María Chacón y Calvo desde la perspectiva cultural. Chacón resulta esencial para comprender los vínculos que tuvieron lugar entre España y Cuba en la primera mitad del siglo XX por cuanto fue una figura clave en los contactos que se establecieron entre ambos lados del Atlántico. Su doble condición de investigador y diplomático le permitió acceder a la elite intelectual española convirtiéndose en un interlocutor de excelencia para el fomento de las relaciones culturales entre ambas naciones. Asimismo, trataremos de comprobar el grado de influencia que tuvo su experiencia española cuando se desempeñó como gestor cultural en la Secretaría de Educación cubana.

With the purpose of renewing the approach offered up to now on Hispanic Americanism in José María Chacón y Calvo, the issue will be addressed, with an emphasis on the cultural topic. His figure is essential to understand the links that took place between Spain and Cuba in the first half of the twentieth century. Chacón was key in the contact spaces that were established between both sides of the Atlantic. His double status as researcher and diplomat allowed him to access the Spanish intellectual elite and be an interlocutor of excellence with the aim of promoting cultural relations between both nations. We will check that his work in Cuba was influenced by his experience as a cultural agent in Spain.
Awa ou la difficile équation du féminin africain
Authors: Thérenty Marie-Ève
Published: October 2019

Cet article montre les tensions qui caractérisent le mensuel féminin africain Awa dirigé par Annette Mbaye d’Erneville (1964-1973), entre revue et magazine : celui-ci ne se caractérise pas seulement par la polyphonie caractéristique du dispositif médiatique, il se révèle contradictoire, voire agonistique. Étudiant les manières dont les fictions thématisent et allégorisent la femme et leur rapport à la modernité, l’article revient notamment sur la question du titre-personnage, jamais innocente dans un périodique, notamment à travers des comparaisons avec d’autres magazines féminins comme Marie Claire et Elle, discrètement mais régulièrement convoqués dans le magazine, ou Amina lancé en 1973 par Michel de Breteuil. La capacité transfictionnelle du magazine à s’incarner dans un personnage emblématique, Awa, régulièrement mobilisé et invoqué dans les pages du journal et en même temps la diversité des représentations ainsi figurées par les couvertures, les articles, le dessin, les photographies, les rubriques (« les cauris de Mam’Awa »), le courrier des lecteurs et même par les fictions montrent la difficulté de l’équation du féminin.
Reading « Hairstories » and « Hairitages » in Léonora Miano’s and Rokhaya
Diallo’s Works
Authors: Montlouis-Gabriel Johanna
Published: October 2019

This article aims at analyzing a distinctive symbol of black women :
their hair. In the last decade, many Afro-feminists (in America, France, the
Caribbean and many other countries) have been reclaiming hair as part of their
heritage and embracing its natural « nappy » state (for « natural » and « happy »).
In my analysis of hair, I will compare and contrast how Léonora Miano in her novel
Blues pour Élise and her short story « Corpus Christi » and Rokhaya Diallo,
in her graphic novel Pari(s) d’amies !, seek to replace the self-loathing
and deprecating narratives that women of color are commonly told about their hair
and their physique. Instead, they reclaim these negative images of hair as well as
of other bodily features by self-love and self-fulfillment. While some characters
may still be struggling with this idea, I argue that the repossessing of one’s own
hair constitutes a performative act.
Léonora Miano et Virginie Despentes : lectures croisées des masculinités « désaxées »
Authors: Unter Ecker Marjolaine
Published: October 2019

Cet article propose une étude comparée entre les derniers romans de Léonora Miano (Crépuscule du Tourment, deux tomes) et ceux de Virginie Despentes (Vernon Subutex, trois tomes), oeuvres qui se rejoignent dans le « dérangement » des normes, tant sociales que littéraires – notamment romanesques – qu’elles instaurent. La représentation de la masculinité dans ces oeuvres en est un exemple, d’autant plus qu’elle croise tour à tour la question de la classe et celle de la race. Il s’agira de montrer comment, en puisant dans les marges, tant esthétiques que culturelles, ces fictions proposent des alternatives à ces formes de conditions multiples et comment elles instituent finalement des espaces d’émancipation pour les personnages, leurs auteures et plus globalement pour les instances de réception.
Is Genetic Discrimination Back on the Radar? A Commentary on the Recent Court of Appeal Reference Decision on the Genetic Non-Discrimination Act (GNDA)
Authors: Joly Yann , Dalpé Gratien , Pinkesz Miriam
Published: October 2019

In this commentary, we critically review the Quebec Court of Appeal’s reference decision to the effect that the Genetic Non-Discrimination Act (GNDA) is unconstitutional. In sum, the court held that the federal government exceeded its criminal law power through the GNDA, as the Act did not have a valid criminal law purpose. The decision was met with opposition, as advocacy groups for Canadians suffering from genetic diseases or genetic predispositions viewed the GNDA as a step in the right direction and were hopeful that it would offer protection from genetic discrimination. In closing, we argue that the consequences of the Court of Appeal’s opinion will be less dire than anticipated by some advocacy groups. In fact, we suggest that this decision brings about a unique opportunity for progress, where stakeholders can engage the public and policymakers in a forward- looking debate on the use of genetic information.
ЧИТАТИ, БИТИ И ТУМАЧИТИ
Authors: Марић Андреја
Published: October 2019

Обимна научна и књижевнокритичка дјелатност Ранка Поповићаупотпуњена је 2017. године још једном књигом знаковитог насло-ва, Читати и бити. Књижевне анализе, која је у издању Друштванаставника српског језика и књижевности објављена као трећа књига уоквиру библиотеке Српски језик и књижевност. Неки од текстова из овекњиге први сусрет са читаоцима имали су у претходним бројевима часо-писа Прилози настави српског језика и књижевности, те је њихово обја-вљивање на једном мјесту, заједно са другим Поповићевим студијамасличне тематике и проблематике, био сасвим логичан потез. Иза овихтекстова стоји врсно и изоштрено перо универзитетског професора којије све теме о којима је у овој књизи писао брусио на предавањима, насто-јећи да, кроз дугогодишњу праксу, студенте, будуће професоре српскогјезика и књижевности, научи како да мисле о књижевности и како да јетумаче. Наступајући из позиције професора који широко, свеобухватно,такорећи онтолошки, приступа књижевности, учинио је да ова књигаможе бити не само корисна наставницима српске књижевности (што је,како аутор наглашава, била основна намјера приликом писања) него изанимљива свим љубитељима писане ријечи и трагаоцима за слојевимазначења у књижевним текстовима.
Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin
Authors: Stowe Cassandra L , Burley Thomas A , Allan Helen , Vinci Maria , Kramer-Marek Gabriela , Ciobota Daniela M , Parkinson Gary N , Southworth Tara L , Agliardi Giulia , Hotblack Alastair , Lythgoe Mark F , Branchini Bruce R , Kalber Tammy L , Anderson James C , Pule Martin A
Published: October 2019

Bioluminescence imaging (BLI) is ubiquitous in scientific research for the sensitive tracking of biological processes in small animal models. However, due to the attenuation of visible light by tissue, and the limited set of near-infrared bioluminescent enzymes, BLI is largely restricted to monitoring single processes in vivo. Here we show, that by combining stabilised colour mutants of firefly luciferase (FLuc) with the luciferin (LH2) analogue infraluciferin (iLH2), near-infrared dual BLI can be achieved in vivo. The X-ray crystal structure of FLuc with a high-energy intermediate analogue, 5’-O-[N-(dehydroinfraluciferyl)sulfamoyl] adenosine (iDLSA) provides insight into the FLuc-iLH2 reaction leading to near-infrared light emission. The spectral characterisation and unmixing validation studies reported here established that iLH2 is superior to LH2 for the spectral unmixing of bioluminescent signals in vivo; which led to this novel near-infrared dual BLI system being applied to monitor both tumour burden and CAR T cell therapy within a systemically induced mouse tumour model.
Structure-based inhibitors of amyloid beta core suggest a common interface with tau
Authors: Griner Sarah L , Seidler Paul , Bowler Jeannette , Murray Kevin A , Yang Tianxiao Peter , Sahay Shruti , Sawaya Michael R , Cascio Duilio , Rodriguez Jose A , Philipp Stephan , Sosna Justyna , Glabe Charles G , Gonen Tamir , Eisenberg David S
Published: October 2019

Alzheimer’s disease (AD) pathology is characterized by plaques of amyloid beta (Aβ) and neurofibrillary tangles of tau. Aβ aggregation is thought to occur at early stages of the disease, and ultimately gives way to the formation of tau tangles which track with cognitive decline in humans. Here, we report the crystal structure of an Aβ core segment determined by MicroED and in it, note characteristics of both fibrillar and oligomeric structure. Using this structure, we designed peptide-based inhibitors that reduce Aβ aggregation and toxicity of already-aggregated species. Unexpectedly, we also found that these inhibitors reduce the efficiency of Aβ-mediated tau aggregation, and moreover reduce aggregation and self-seeding of tau fibrils. The ability of these inhibitors to interfere with both Aβ and tau seeds suggests these fibrils share a common epitope, and supports the hypothesis that cross-seeding is one mechanism by which amyloid is linked to tau aggregation and could promote cognitive decline.
Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72
Authors: Laflamme Carl , McKeever Paul M , Kumar Rahul , Schwartz Julie , Kolahdouzan Mahshad , Chen Carol X , You Zhipeng , Benaliouad Faiza , Gileadi Opher , McBride Heidi M , Durcan Thomas M , Edwards Aled M , Healy Luke M , Robertson Janice , McPherson Peter S
Published: October 2019

Antibodies are a key resource in biomedical research yet there are no community-accepted standards to rigorously characterize their quality. Here we develop a procedure to validate pre-existing antibodies. Human cell lines with high expression of a target, determined through a proteomics database, are modified with CRISPR/Cas9 to knockout (KO) the corresponding gene. Commercial antibodies against the target are purchased and tested by immunoblot comparing parental and KO. Validated antibodies are used to definitively identify the most highly expressing cell lines, new KOs are generated if needed, and the lines are screened by immunoprecipitation and immunofluorescence. Selected antibodies are used for more intensive procedures such as immunohistochemistry. The pipeline is easy to implement and scalable. Application to the major ALS disease gene C9ORF72 identified high-quality antibodies revealing C9ORF72 localization to phagosomes/lysosomes. Antibodies that do not recognize C9ORF72 have been used in highly cited papers, raising concern over previously reported C9ORF72 properties.
Effect of femtosecond laser pulse repetition rate on nonlinear optical properties of organic liquids
Authors: Maurya Sandeep Kumar , Yadav Dheerendra , Goswami Debabrata
Published: October 2019

The effect of the repetition rate of femtosecond laser pulses on the two-photon absorption and nonlinear refraction of pure organic liquids is presented using the conventional Z-scan technique. Such a study provides a way to determine the nature of light-matter interaction, explicitly enabling the identification of the linear versus nonlinear regimes. Based on the type of light-matter interaction, we have identified the thermal load dissipation time for the organic liquids. Our experimental results are in good agreement with the theoretically calculated decay time for the dissipation of thermal load.
Plant and insect herbivore community variation across the Paleocene–Eocene boundary in the Hanna Basin, southeastern Wyoming
Authors: Azevedo Schmidt Lauren E. , Dunn Regan E. , Mercer Jason , Dechesne Marieke , Currano Ellen D.
Published: October 2019

Ecosystem function and stability are highly affected by internal and external stressors. Utilizing paleobotanical data gives insight into the evolutionary processes an ecosystem undergoes across long periods of time, allowing for a more complete understanding of how plant and insect herbivore communities are affected by ecosystem imbalance. To study how plant and insect herbivore communities change during times of disturbance, we quantified community turnover across the Paleocene­–Eocene boundary in the Hanna Basin, southeastern Wyoming. This particular location is unlike other nearby Laramide basins because it has an abundance of late Paleocene and Eocene coal and carbonaceous shales and paucity of well-developed paleosols, suggesting perpetually high water availability. We sampled approximately 800 semi-intact dicot leaves from five stratigraphic levels, one of which occurs late in the Paleocene–Eocene thermal maximum (PETM). Field collections were supplemented with specimens at the Denver Museum of Nature & Science. Fossil leaves were classified into morphospecies and herbivore damage was documented for each leaf. We tested for changes in plant and insect herbivore damage diversity using rarefaction and community composition using non-metric multidimensional scaling ordinations. We also documented changes in depositional environment at each stratigraphic level to better contextualize the environment of the basin. Plant diversity was highest during the mid-late Paleocene and decreased into the Eocene, whereas damage diversity was highest at the sites with low plant diversity. Plant communities significantly changed during the late PETM and do not return to pre-PETM composition. Insect herbivore communities also changed during the PETM, but, unlike plant communities, rebound to their pre-PETM structure. These results suggest that insect herbivore communities responded more strongly to plant community composition than to the diversity of species present.