bluuebunny/crossref_metadata_2025 huggingface dataset:
How does principal’s instructional leadership shape teacher performance mediated by teacher self-efficacy in Indonesian education context?
Authors: Elfira  , Rasdiana  , Fitrawati  , Jasman Muh Wahyudi , Reski Kiki , Anwar Amriyadi , Enaldi
Published: November 2024

Introduction

This study seeks to examine the relationships among principal instructional leadership (PIL), teacher self-efficacy (TSE), and teacher performance (TP) within the Indonesian educational setting, specifically in schools implementing the Merdeka Belajar curriculum.

Methods

Employing a quantitative approach utilizing Partial Least Square Structural Equation Modeling (PLS-SEM), this research involved a sample of 127 productive teachers randomly selected from 247 teachers. Surveys were administered to measure perceptions of PIL, TSE, and TP, and relevant literature was reviewed to provide theoretical frameworks and research hypotheses.

Results

The findings reveal significant direct relationships between PIL and both TSE (0.721) and TP (0.598), indicating that strong instructional leadership positively influences teachers’ self-efficacy and performance. Moreover, TSE is found to directly impact TP (0.358), suggesting that teachers’ beliefs in their capabilities play a crucial role in their instructional practices and outcomes. TSE is also identified as a significant mediator in the relationship between PIL and TP (0.258), highlighting the importance of fostering teachers’ self-efficacy to enhance their performance indirectly through instructional leadership.

Discussion

This research underscores the crucial significance of instructional leadership in influencing school culture, which ultimately affects teacher confidence and facilitates teacher performance. By understanding the mechanisms through which PIL impacts TSE and TP, educational leaders can implement strategies to foster a supportive environment that empowers teachers.
Complexities of student dropout in higher education: a multidimensional analysis
Authors: Barragán Moreno Sandra Patricia , González Támara Leandro
Published: November 2024

Introduction

Student dropout, as a dynamic and complex system, requires a broad conceptualization. The aim of this article is to analyze the concept of student dropout in higher education, with the aim of effectively addressing it at various levels, including both institutional and societal.

Methods

Using a mixed-methods approach, dropout patterns were traced, and a model was designed and validated using anonymized data from 17,328 students at a Colombian higher education institution offering face-to-face programs.

Results

Results from decision trees and survival analysis highlight the significance of economic and academic factors in increasing the risk of dropout and contributing to low graduation rates. It has been confirmed that the first two years of enrollment in the educational institution are crucial for the likelihood of dropout, and that extended time spent at the institution also increases the risk of dropout.

Discussion

The study highlights the dynamic complexity of student dropout and emphasizes the importance of continuously updating models by integrating diverse analysis techniques. Socioeconomic status and academic performance emerged as key factors, with a focus on students at intermediate levels.
Effects of probiotic supplementation on bone health in postmenopausal women: a systematic review and meta-analysis
Authors: Wang Fang , Wei Wei , Liu Peng Ju
Published: November 2024

Context

The beneficial effects of probiotic supplementation on bone health in postmenopausal women require further validation.

Objective

This study systematically reviewed and conducted a meta-analysis of randomized controlled trials (RCTs) to assess the relationship between probiotic supplementation and changes in bone mineral density (BMD) and bone turnover markers (BTMs) among postmenopausal women.

Methods

A systematic search was conducted across four databases to retrieve data on lumbar spine BMD, hip BMD, collagen type 1 cross-linked C-telopeptide (CTX), receptor activator of nuclear factor-κB ligand (RANKL), osteocalcin (OC), osteoprotegerin (OPG), N-terminal propeptide of type 1 procollagen (P1NP), and bone-specific alkaline phosphatase (BALP) in postmenopausal women. Eligible RCTs were quantitatively analyzed using random-effects meta-analyses. Additional analyses, including subgroup, sensitivity, and meta-regression analyses, were performed.

Results

Twelve RCTs involving 1183 postmenopausal women were included. Compared with the control group, postmenopausal women who received probiotic supplementation showed significantly greater BMD in both the lumbar spine (standardized mean difference [SMD] = 0.60, 95% confidence interval [CI] 0.14 to 1.05) and the hip (SMD = 0.74, 95%CI 0.15 to 1.33). Additionally, probiotic supplementation was associated with reduced levels of CTX (SMD = -1.51, 95%CI -1.88 to -0.41) and BALP (SMD = -1.80, 95%CI -2.78 to -0.81). No significant differences were found between the probiotic and control groups in terms of other BTMs. Subgroup analyses revealed that the increase in BMD due to probiotic supplementation was more significant in postmenopausal women with osteopenia than in those with osteoporosis. The meta-analysis results for both lumbar spine and hip BMD remained robust after conducting sensitivity analyses and meta-regressions.

Conclusion

Supplementation with probiotics may increase BMD among postmenopausal women, with stronger evidence in women with osteopenia than osteoporosis. Further RCTs are suggested to confirm and refine these findings.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024576764.
Evaluating health-related quality of life in Ethiopia: systematic review and meta-analysis of EQ-5D-based studies
Authors: Tarekegn Tenaw Baye , Gebrie Desye , Kassaw Abebe Tarekegn , Dagne Taye Abebe , Girmaw Fentaw , Ashagrie Getachew
Published: November 2024

Background

Health-related quality of life (HRQoL) is crucial for understanding how health conditions impact overall well-being. The EuroQol-5 Dimension (EQ-5D) is a widely used tool for measuring HRQoL across diseases. In Ethiopia, this tool has been employed to assess HRQoL across various healthcare settings. This study aims to summarize EQ-5D-derived health outcomes in Ethiopian populations and identify key determinants influencing these outcomes.

Methods

A systematic search of PubMed, Embase, and Scopus was conducted through May 2024, with no publication date restrictions, focusing on HRQoL and EQ-5D instruments in Ethiopian populations. Grey literature searches were also performed using Google's Advanced Search. Cross-sectional studies across various diseases were included. Data were extracted by two independent reviewers, and pooled mean EQ-5D utility and EQ-5D visual analog scale (EQ-VAS) scores were calculated using a random-effects model in STATA software version 17. Study quality was evaluated using the Agency for Healthcare Research and Quality (AHRQ) checklist, and heterogeneity was assessed using the I² statistic.

Results

Fourteen cross-sectional studies involving 5,639 patients from 2019 to 2024 in Ethiopia were analyzed. Health utility values varied across diseases, with pain/discomfort and anxiety/depression being the most commonly affected dimensions. The pooled EQ-5D utility for HIV patients was 0.88, and the EQ-VAS score was 76.59. For diabetes mellitus (DM) patients, the pooled utility was 0.78, and the EQ-VAS score was 69.36. For COVID-19 patients, the pooled utility was 0.86, and the EQ-VAS score was 74.56. Cancer patients had a pooled EQ-VAS score of 67.87.

Conclusion

The EQ-5D is a reliable tool for measuring HRQoL in Ethiopian patients across various diseases. The study's pooled EQ-5D scores provide valuable insights for future economic evaluations in the Ethiopian healthcare system.

Systematic Review Registration

https://doi.org/10.1136/bmjopen-2024-085354, PROSPERO (CRD42024505028).
Prenatal detection of novel compound heterozygous variants of the PLD1 gene in a fetus with congenital heart disease
Authors: Zhu Linyan , Chen Mei , Shi Yubo , Huang Xiaxi , Ding Huiqing
Published: November 2024

Background

Congenital heart disease (CHD) is the most common birth defect and heart valve defects are the most common cardiac defect, accounting for over 25% of all congenital heart diseases. To date, more than 400 genes have been linked to CHD, the genetic analysis of CHD cases is crucial for both clinical management and etiological determination. Patients with autosomal-recessive variants of PLD1 are predisposed to Cardiac Valvular Dysplasia-1 (CVDP1), which predominantly affects the right-sided heart valves, including the pulmonic, tricuspid, and mitral valves.

Methods

Databases were utilized to predict the impact of the c.1062-59A>G variant on splicing. Whole-exome sequencing (WES), reverse transcription polymerase chain reaction (RT-PCR), Sanger sequencing, and TA clone sequencing were conducted on both the parents and the fetus.

Results

A compound heterozygous variation in the PLD1(NM_002662.5):c.1937G>C (p. G646A) from the father and PLD1(NM_002662.5):c.1062-59A>G from the mother, was identified and confirmed in the fetus. The c.1937G>C (p. G646A) and the c.1062-59A>G variants were all classified as variant of uncertain significance (VUS) per ACMG guidelines. RT-PCR and TA clone sequencing revealed a 76-bp intronic insertion and exon 11 skipping in the proband and her mother’s transcripts, causing a frameshift and premature stop codon in PLD1. Consequently, after being informed about the risks of their variant of unknown significance (VUS), the couple chose pre-implantation genetic testing for monogenic disorders (PGT-M) and had a healthy child.

Conclusion

Our study identified novel variants to expand the mutation spectrum of CHD and provided reliable evidence for the recurrent risk and reproductive care options.
Long-term efficacy and safety of dupilumab for moderate-to-severe atopic dermatitis: a prospective real-world cohort study in China
Authors: Wang Yuyi , Jia Ruiling , Hu Qin , Tao Xiao , He Qi , Luo Guangying , Xiong Qiong , Zhang Zhongyu , Xiao Yujuan , Liu Yi
Published: November 2024

Backgrounds

Dupilumab has demonstrated remarkable efficacy and safety in clinical trials for moderate-to-severe atopic dermatitis (AD). However, long-term real-world evidence, especially in the Chinese population, remains limited.

Objective

To investigate the long-term efficacy and safety of dupilumab for moderate-to-severe AD in a real-world clinical setting in China and analyze factors that may influence its long-term treatment outcomes.

Methods

This prospective, observational real-world study included moderate-to-severe AD patients from the AD cohort of the dermatology department of Chongqing Hospital of Traditional Chinese Medicine who received dupilumab treatment for≥52 weeks. Efficacy and adverse events were assessed at baseline, weeks 4, 16, 24, and 52. Multivariate logistic regression analysis was used to identify predictive factors for achieving EASI 50 and EASI 75 at week 52.

Results

A total of 124 patients were included. At week 52, EASI, SCORAD, IGA, NRS, and DLQI scores were significantly improved compared to baseline. The proportions of patients achieving EASI-50/75 were 50.81%/29.84%, 72.58%/42.74%, 75%/53.23%, and 67.74%/41.94% at weeks 4, 16, 24 and 52, respectively. Female sex, absence of atopic comorbidities, higher baseline EASI, and medication compliance were positive predictive factors for 52-week EASI-50/75. Eosinophil elevation predicted lower EASI-50 attainment. Nineteen adverse events occurred during the 52-week period (incidence rate: 14.52%), mostly mild and manageable.

Conclusions

Dupilumab demonstrated significant efficacy and a low incidence of adverse events over 52 weeks in Chinese patients with moderate-to-severe AD, making it an effective and safe long-term treatment option. Predictive factors were identified to guide treatment optimization.
WBP1L regulates hematopoietic stem cell function and T cell development
Authors: Krayem Imtissal , Grusanovic Srdjan , Duric Iris , Pavliuchenko Nataliia , Danek Petr , Borna Simon , Sekeresova Kralova Jarmila , Skopcova Tereza , Pokorna Jana , Alberich-Jorda Meritxell , Brdicka Tomas
Published: November 2024

WW domain binding protein 1-like (WBP1L), also known as outcome predictor of acute leukemia 1 (OPAL1), is a transmembrane adaptor protein, expression of which was shown to correlate with ETV6-RUNX1 translocation and favorable prognosis in childhood leukemia. It has a broad expression pattern in hematopoietic and non-hematopoietic cells. Our previous work described WBP1L as a regulator of CXCR4 signaling and hematopoiesis. Here, we show that hematopoiesis in the mice with Wbp1l germline deletion is dysregulated, already at the level of hematopoietic stem cells and early progenitors. We further demonstrate that thymi of WBP1L-deficient mice are significantly enlarged and contain increased numbers of thymocytes of all subsets. This can potentially be explained by increased generation of multipotent progenitors 4 (MPP4) in the bone marrow, from which the thymus-seeding progenitors are derived. We also observed increases in multiple cell types in the blood. In addition, we show that WBP1L regulates hematopoietic stem cell functionality and leukocyte progenitor proliferation and gene expression during hematopoietic stem and progenitor cell transplantation, which contribute to more efficient engraftment of WBP1L-deficient cells. WBP1L thus emerges as a regulator of hematopoietic stem and progenitor cell function, which controls leukocyte numbers at the steady state and after bone marrow transplantation.
Probiotics combined with prebiotics alleviated seasonal allergic rhinitis by altering the composition and metabolic function of intestinal microbiota: a prospective, randomized, double-blind, placebo-controlled clinical trial
Authors: Hou Yangfan , Wang Dan , Zhou Shuru , Huo Caifang , Chen Haijuan , Li Fangxia , Ding Minjuan , Li Hongxin , Zhao Hongyan , He Jin , Da Hongju , Ma Yu , Qiang Zhihui , Chen Xiushan , Bai Cairong , Cui Jing , Gao Na , Liu Yun
Published: November 2024

Background

Numerous studies have established that probiotics or prebiotics can relieve the symptoms of allergic rhinitis (AR), but their mechanism of action remain underexplored. This study aimed to observe the clinical efficacy of probiotics combined with prebiotics in seasonal AR patients and explore their underlying mechanisms.

Methods

We conducted a prospective, randomized, double-blind, placebo-controlled clinical trial. The test group was given probiotics combined with prebiotics, whereas the placebo group was administered simulated preparation for 90 days. Outcome measures included total nasal symptom score (TNSS), visual analog scale, rhinitis quality of life questionnaire, fractional exhaled nitric oxide, and the rate and intensity of Loratadine use. Serum TNF-α, INF-γ, IL-4, IL-17, and IgE levels were measured by enzyme-linked immunosorbent assay. Intestinal microbiota was detected by 16S rRNA gene sequencing and quantitative PCR. Short-chain fatty acids were analyzed by gas chromatography-mass spectrometry.

Results

106 participants (N = 53 for both test group and placebo group) completed the study. From baseline to day 91, mean difference between groups (MDBG) in the reduction of TNSS was -1.1 (-2.2, -0.1) (P = 0.04); MDBG in the increment of TNF-α was 7.1 pg/ml (95% CI: 0.8, 13.4, P = 0.03); the INF-γ level was significantly increased (P = 0.01), whereas that of IL-17 (P = 0.005) was significantly decreased in the test group, whilst mean difference within groups was not statistically significant in the placebo group; MDBG in the increment of acetate was 12.4% (95% CI: 7.1%, 17.6%, P <0.001). After the administration of probiotics and prebiotics, the composition and metabolic function of the intestinal microbiota were significantly altered and positively related to the beneficial effect on seasonal AR patients.

Conclusion

Probiotics combined with prebiotics administered for 90 days significantly attenuated the symptoms of seasonal AR patients, which may related to fluctuations in the composition and metabolic function of the intestinal microbiota and further ameliorating host immunity.
Advances in Trop-2 targeted antibody-drug conjugates for breast cancer: mechanisms, clinical applications, and future directions
Authors: Tong Yujun , Fan Xiaobing , Liu Huan , Liang Tiantian
Published: November 2024

Breast cancer remains a leading cause of cancer-related deaths among women worldwide, highlighting the need for novel therapeutic strategies. Trophoblast cell surface antigen 2 (Trop-2), a type I transmembrane glycoprotein highly expressed in various solid tumors including all subtypes of breast cancer, has emerged as a promising target for cancer therapy. This review focuses on recent advancements in Trop-2-targeted antibody-drug conjugates (ADCs) for breast cancer treatment. We comprehensively analyzed the structure and mechanism of action of ADCs, as well as the role of Trop-2 in breast cancer progression and prognosis. Several Trop-2-targeted ADCs, such as Sacituzumab Govitecan (SG) and Datopotamab Deruxtecan (Dato-DXd), have demonstrated significant antitumor activity in clinical trials for both triple-negative breast cancer (TNBC) and hormone receptor-positive/HER2-negative (HR+/HER2-) breast cancer. We systematically reviewed the ongoing clinical studies of these ADCs, highlighting their efficacy and safety profiles. Furthermore, we explored the potential of combining Trop-2-targeted ADCs with other therapeutic modalities, including immunotherapy, targeted therapies, and small molecule inhibitors. Notably, Trop-2-targeted ADCs have shown promise in reprogramming the tumor microenvironment through multiple signaling pathways, potentially enhancing antitumor immunity. This review aims to provide new insights and research directions for the development of innovative breast cancer therapies, offering potential solutions to improve treatment outcomes and quality of life for breast cancer patients.
Assessment of mechanical performance of sustainable structural mud insulated panels
Authors: Khan Asad , Adil Mohammad , Dan Danhui , Khan Muhammad Adeel , Ahmad Mahmood , Khan Muhammad Salman , Sabri Mohanad Muayad Sabri
Published: November 2024

Composite construction materials are extensively employed and have proven to be more effective than their individual components, such as steel and concrete. This is because composites combine the strengths of different materials, resulting in enhanced properties such as increased strength-to-weight ratios, better durability, and improved thermal efficiency. However, despite the strong structural properties and energy-saving benefits of reinforced concrete sandwich panels, their use is restricted in many rural regions of developing nations like Pakistan, largely because of the economic limitations faced by the communities. Therefore, this study introduces cost-effective structural mud insulated panels (SMIPs) that utilize mud wythes and evaluates their mechanical performance. These panels consist of a lightweight Expanded Polystyrene (EPS) foam core, sandwiched between two galvanized steel-reinforced mud layers. The study includes flexural, compression, diagonal tension, and water absorption tests. Flexural tests revealed that the panels have substantial load-bearing capacity under bending forces. Whereas, Compression tests showed that the panels possess adequate strength and stiffness to support moderate structural loads. Additionally, Diagonal tension tests confirmed the panels’ ability to resist significant in-plane loads. Water absorption tests also indicated that the panels demonstrated adequate moisture resistance, staying within the acceptable limit of 15%. These findings highlight the mechanical and hydric properties of SMIPs, underscoring their potential in sustainable construction, especially in economically constrained regions.
Cross-sectional assessment of perception and attitude of pharmacy students towards pharmaceutical promotion: a study from developing country, Pakistan
Authors: Gillani Ali Hassan , Arshad Hafsa , Arshed Muhammad , Jairoun Ammar , Shukar Sundus , Akbar Jamshaid , Hussain Azzah Khadim , Malik Hafiz Muhammad Abbas , Ibrahim Mohamed Izham Mohamed , Fang Yu
Published: November 2024

Background

The pharmaceutical promotion is “all informational and persuasive activities by manufacturers and distributors, the effect of which is to induce the prescription, supply, purchase and/or use of medicinal drugs. These promotional activities affect the dispensing behavior of physicians and pharmacists and influence begins from educational institutes.

Objective

Our study’s main aim was to evaluate opinion and attitude of pharmacy students towards pharmaceutical promotion.

Materials and methods

A cross-sectional online survey was conducted among 3rd, 4th and final year pharmacy students of 3 public and 3 private sector universities in Punjab Pakistan. A modified version of pre available questionnaire was used to collect data from students between June 2020 and December 2020. The tool was made available through a Google Form, assessable to students via provided link. We utilized the snowball sampling technique. Descriptive statistics were used to evaluate the demographics, while Chi-square and t-test were used to analyze associations between demographics and items. Data were analyzed using SPSS version 21.0.

Results

A total of 1,195 students participated in the survey with an average age of 22.2 ± 1.2 years. Nearly 2/3rd of the students were males (62.2%) and a significant proportion (87.3%) of pharmacy students had never taken part in any training provided by pharmaceutical company. Among all, 51.9% confirmed that pharmacists who frequently interact with medical representatives tend to dispense more antibiotics. Additionally, 42.1% indicated they may dispense antibiotics under the influence of promotion. Pharmacy students in senior college years and those with lower parental exhibited significantly more perception and attitude scores (p < 0.001).

Conclusion

A significant number of students concurred with the notion that promotional activities could impact dispensing practices and they also believed that such activities contribute to the growing issue of irrational antibiotic use. This study underscores the necessity for a heightened emphasis on the educational needs of pharmacy students.
Hypothyroidism correlates with osteoporosis: potential involvement of lipid mediators
Authors: Leng Pengyuan , Qiu Ying , Zhou Mengxue , Zhu Yuhang , Yin Na , Zhou Mingming , Wu Weili , Liu Min
Published: November 2024

Background

Observational studies have demonstrated a correlation between thyroid dysfunction and osteoporosis (OP); however, the underlying causality has yet to be fully elucidated.

Methods

The necessary dataset was sourced from public databases. Initially, instrumental variables (IVs) were selected based on three primary hypotheses. Subsequently, Cochran’s Q test was employed to exclude IVs exhibiting heterogeneity. The MR-PRESSO test and the leave-one-out sensitivity test were further applied to detect potential pleiotropy. Inverse variance was utilized for the analysis. This study primarily utilized the inverse variance weighted (IVW) model for Mendelian analysis. Since Type 1 diabetes mellitus can also contribute to the development of osteoporosis, this study additionally employed multivariate Mendelian analysis. Furthermore, 249 circulating metabolites were selected for mediation analysis in the Mendelian randomization framework.

Results

In this study, the two-sample Mendelian randomization (MR) analysis primarily employed the random-effects IVW model and demonstrated a causal relationship between hypothyroidism (OR = 1.092, 95% CI: 1.049–1.137, p < 0.001) and hyperthyroidism (OR = 1.080, 95% CI: 1.026–1.137, p = 0.003) with the risk of OP. No causal relationships were identified between FT3, FT4, TSH, and the risk of OP (p > 0.05). The results of the multivariate Mendelian randomization (MVMR) analysis indicated that hyperthyroidism was no longer a risk factor for OP (OR = 0.984, 95% CI: 0.918–1.055, p = 0.657), whereas hypothyroidism persisted as a risk factor (OR = 1.082, 95% CI: 1.021–1.147, p = 0.008). The mediated Mendelian randomization analysis revealed that hypothyroidism may exert an indirect effect on OP via triglycerides in large VLDL, mediating approximately 2.47% of the effect.

Conclusion

This study identifies a potential link between hypothyroidism and OP, possibly mediated indirectly via triglyceride levels in large VLDL. Further investigations are required to elucidate the direct or indirect causal mechanisms underlying this association.
RIG012 assists in the treatment of pneumonia by inhibiting the RIG-I-like receptor signaling pathway
Authors: Zhang Shi , Chen Hanbing , Xie Jianfeng , Huang Lili
Published: November 2024

Objective

Pneumonia is a common clinical condition primarily treated with antibiotics and organ support. Exploring the pathogenesis to identify therapeutic targets may aid in the adjunct treatment of pneumonia and improve survival rates.

Methods

Transcriptomic data from peripheral blood of 183 pneumonia patients were analyzed using Gene Set Variation Analysis (GSVA) and univariate Cox regression analysis to identify signaling pathways associated with pneumonia mortality. A pneumonia mouse model was established via airway injection of Klebsiella pneumoniae, and pathway-specific blockers were administered via tail vein infusion to assess whether the identified signaling pathways impact the mortality in pneumonia.

Results

The combination of GSVA and Cox analysis revealed 17 signaling pathways significantly associated with 28-day mortality in pneumonia patients (P < 0.05). Notably, the RIG-I-like receptor signaling pathway exhibited the highest hazard ratio of 2.501 with a 95% confidence interval of [1.223–5.114]. Infusion of RIG012 via the tail vein effectively inhibited the RIG-I-like receptor signaling pathway, significantly ameliorated lung injury in pneumonia mice, reduced pulmonary inflammatory responses, and showed a trend toward improved survival rates.

Conclusion

RIG012 may represent a novel adjunctive therapeutic agent for pneumonia.
Risk factors and clinical prediction models for low-level viremia in people living with HIV receiving antiretroviral therapy: an 11-year retrospective study
Authors: Zhang Wenhui , Shi Jinchuan , Wang Ying , Li Er , Yan Dingyan , Zhang Zhongdong , Zhu Mingli , Yu Jianhua , Wang Yi
Published: November 2024

Objective

This study explores the risk factors for low-level viremia (LLV) occurrence after ART and develops a risk prediction model.

Method

Clinical data and laboratory indicators of people living with HIV (PLWH) at Hangzhou Xixi Hospital from 5 April 2011 to 29 December 2022 were collected. LASSO Cox regression and multivariate Cox regression analysis were performed to identify laboratory indicators and establish a nomogram for predicting LLV occurrence. The nomogram’s discrimination and calibration were assessed via ROC curve and calibration plots. The concordance index (C-index) and decision curve analysis (DCA) were used to evaluate its effectiveness.

Result

Predictive factors, namely, age, ART delay time, white blood cell (WBC) count, baseline CD4+ T-cell count (baseline CD4), baseline viral load (baseline VL), and total bilirubin (TBIL), were incorporated into the nomogram to develop a risk prediction model. The optimal model (which includes 6 variables) had an AUC for LLV after 1-year, 3-year, and 5-year of listing of 0.68 (95% CI, 0.61–0.69), 0.69 (95% CI, 0.65–0.70), and 0.70 (95% CI, 0.66–0.71), respectively. The calibration curve showed high consistency between predicted and actual observations. The C-index and DCA indicated superior prediction performance of the nomogram. There was a significant difference in CD4 levels between LLV and non-LLV groups during the follow-up time. The dynamic SCR, ALT, TG and BG levels and occurrence of complications differed significantly between the high- and low-risk groups.

Conclusion

A simple-to-use nomogram containing 6 routinely detected variables was developed for predicting LLV occurrence in PLWH after ART.
Autoantibodies in neuromuscular disorders: a review of their utility in clinical practice
Authors: Loser Valentin , Vicino Alex , Théaudin Marie
Published: November 2024

A great proportion of neuromuscular diseases are immune-mediated, included myasthenia gravis, Lambert-Eaton myasthenic syndrome, acute- and chronic-onset autoimmune neuropathies (anti-MAG neuropathy, multifocal motor neuropathy, Guillain-Barré syndromes, chronic inflammatory demyelinating polyradiculoneuropathy, CANDA and autoimmune nodopathies), autoimmune neuronopathies, peripheral nerve hyperexcitability syndromes and idiopathic inflammatory myopathies. The detection of autoantibodies against neuromuscular structures has many diagnostic and therapeutic implications and, over time, allowed a better understanding of the physiopathology of those disorders. In this paper, we will review the main autoantibodies described in neuromuscular diseases and focus on their use in clinical practice.
Sensory reweighting and self-motion perception for postural control under single-sensory and multisensory perturbations in older Tai Chi practitioners
Authors: Liu Xiao-xia , Wang Guozheng , Zhang Ruixuan , Ren Zhuying , Wang Di , Liu Jun , Wang Jian , Gao Ying
Published: November 2024

Purpose

Impairment in perception and sensory reweighting could predispose older adults to falls. This exploratory study aimed to investigate the differences in sensory reweighting and self-motion perception for postural control under single-sensory and multisensory perturbations between older Tai Chi (TC) practitioners and healthy active older controls.

Methods

Twenty-four TC practitioners and 23 age-matched non-practitioners were recruited in this observational study. Participants stood on a force plate with or without a foam surface (baseline), followed by 36 s of visual rotation stimuli, vestibular rotation stimuli, or reduced somatosensory input (adaptation), and then continued standing for 44 s (reintegration). The center-of-pressure (COP) trajectories and self-motion perception were recorded. COP signals were analyzed using traditional sway, multiscale entropy, and wavelet analysis methods and the time-window-of-integration model to examine the postural balance performance and the flexibility and speed of sensory reweighting.

Results

Significant interaction effects of group with sensory perturbation and group with time window on COP parameters were observed (p < 0.05). Compared with non-practitioners, TC practitioners exhibited higher postural stability and complexity as the difficulty of standing tasks increased and smaller time windows to return to baseline levels as disturbance time evolved. Moreover, TC practitioners exhibited significantly greater weighting on unperturbed sensory systems, lower weighting on perturbed sensory systems for postural control, and higher self-motion perception ability under visual, vestibular, and visual-vestibular perturbations (p < 0.05).

Conclusion

Long-term TC practitioners exhibited superior postural stability and adaptability under challenging sensory perturbations, and smaller amplitudes and shorter durations of postural aftereffects over time during adaptation and reintegration. These improvements may be partly attributed to more rapid and flexible sensory reweighting and improved self-motion perception for postural control.
Objective assessment of cognitive fatigue: a bibliometric analysis
Authors: Han Jia-Cheng , Bai Ke , Zhang Chi , Liu Na , Yang Guan , Shang Yu-Xuan , Song Jia-Jie , Su Dan , Hao Yan , Feng Xiu-Long , Li Si-Rui , Wang Wen
Published: November 2024

Aim

The objective of this study was to gain insight into the nature of cognitive fatigue and to identify future trends of objective assessment techniques in this field.

Methods

One thousand and eighty-five articles were retrieved from the Web of Science Core Collection database. R version 4.3.1, VOSviewer 1.6.20, CiteSpace 6.2.R4, and Microsoft Excel 2019 were used to perform the analysis.

Results

A total of 704 institutes from 56 countries participated in the relevant research, while the People’s Republic of China contributed 126 articles and was the leading country. The most productive institute was the University of Gothenburg. Johansson Birgitta from the University of Gothenburg has posted the most articles (n = 13). The PLOS ONE published most papers (n = 38). The Neurosciences covered the most citations (n = 1,094). A total of 3,116 keywords were extracted and those with high frequency were mental fatigue, performance, quality-of-life, etc. Keywords mapping analysis indicated that cognitive fatigue caused by continuous work and traumatic brain injury, as well as its rehabilitation, have become the current research trend. The most co-cited literature was published in Sports Medicine. The strongest citation burst was related to electroencephalogram (EEG) event-related potential and spectral power analysis.

Conclusion

Publication information of related literature on the objective assessment of cognitive fatigue from 2007 to 2024 was summarized, including country and institute of origin, authors, and published journal, offering the current hotspots and novel directions in this field.
Analysis of the correlation and influencing factors between delirium, sleep, self-efficacy, anxiety, and depression in patients with traumatic brain injury: a cohort study
Authors: Fu Zhongmin , Miao Xiaoju , Luo Xian , Yuan Lili , Xie Yan , Huang Shiming
Published: November 2024

Background

Patients with traumatic brain injury (TBI) often experience post-injury anxiety and depression, which can persist over time. However, the relationships between anxiety and depression in TBI patients and delirium, sleep quality, self-efficacy, and serum inflammatory markers require further investigation.

Objective

This study aims to explore the associations of delirium, sleep quality, self-efficacy, and serum inflammatory markers with anxiety and depression in TBI patients, and to examine potential influencing factors.

Methods

We conducted a cohort study involving 127 patients with TBI. Delirium was assessed using the Confusion Assessment Method (CAM) and CAM-ICU, while anxiety, depression, sleep quality, self-efficacy, and pain were evaluated using the appropriate tools, respectively. Serum inflammatory markers (CRP, TNF-α, IL-6) were collected within 1 day post-injury. Generalized estimating equations (GEE) were used to analyze the relationships between delirium, sleep, self-efficacy, and anxiety/depression.

Results

The study identified 56 patients with delirium. Patients with delirium differed significantly from those without delirium in age, TBI classification, sleep duration, CRP levels, TNF-α levels, pain, self-efficacy, and insomnia (P < 0.05). The GEE analysis revealed that delirium, CRP levels, self-efficacy, underlying diseases, insomnia, TBI classification, age, and sleep duration were associated with anxiety symptoms in TBI patients at 6 months post-discharge (P < 0.05). Depression in TBI patients at 6 months post-discharge was not associated with delirium or insomnia but correlated with CRP levels, TBI classification, and self-efficacy (P < 0.05).

Conclusion

TBI patients who experience delirium, insomnia, and low self-efficacy during the acute phase are likely to exhibit more anxiety at the 6-month follow-up. Depression in TBI patients is not associated with delirium or insomnia but is negatively correlated with self-efficacy. CRP levels post-TBI may serve as a biomarker to identify patients at risk of emotional symptoms and potentially accelerate patient recovery.
Microglia: roles and genetic risk in Parkinson’s disease
Authors: Trainor Alex R. , MacDonald Debra S. , Penney Jay
Published: November 2024

The prevalence of neurodegenerative disorders such as Parkinson’s disease are increasing as world populations age. Despite this growing public health concern, the precise molecular and cellular mechanisms that culminate in neurodegeneration remain unclear. Effective treatment options for Parkinson’s disease and other neurodegenerative disorders remain very limited, due in part to this uncertain disease etiology. One commonality across neurodegenerative diseases is sustained neuroinflammation, mediated in large part by microglia, the innate immune cells of the brain. Initially thought to simply react to neuron-derived pathology, genetic and functional studies in recent years suggest that microglia play a more active role in the neurodegenerative process than previously appreciated. Here, we review evidence for the roles of microglia in Parkinson’s disease pathogenesis and progression, with a particular focus on microglial functions that are perturbed by disease associated genes and mutations.
Dietary patterns and diabetic microvascular complications risk: a Mendelian randomization study of European ancestry
Authors: Zhou Xin , Zheng Wenbin , Kong Wen , Zeng Tianshu
Published: November 2024

Purpose

Previous observational studies about the link between dietary factors and diabetic microvascular complications (DMCs) is controversial. Thus, we systemically assessed the potential causal relationship between diet and DMCs risk using Mendelian randomization (MR) methods.

Methods

We used genome-wide association studies (GWAS) statistics to estimate the causal effects of 17 dietary patterns on three common DMCs in European. Summary statistics on dietary intakes were obtained from the UK biobank, and data on DMCs [diabetic retinopathy (DR), diabetic nephropathy (DN), and diabetic neuropathy (DNP)] were obtained from the FinnGen Consortium. A two-sample MR (TSMR) was conducted to explore the causal relationships of dietary habits with DMCs. In addition, multivariable MR analysis (MVMR) was performed to adjust for traditional risk factors for eating habits, and evaluated the direct or indirect effects of diet on DMCs.

Results

TSMR analysis revealed that salad/raw vegetable intake (odd ratio [OR]: 2.830; 95% confidence interval [CI]: 1.102–7.267; p = 0.0306) and fresh fruit intake (OR: 2.735; 95% CI: 1.622–4.611; p = 0.0002; false discovery rate [FDR] = 0.0082) increased the risk of DR, whereas cheese intake (OR: 0.742; 95% CI: 0.563–0.978; p = 0.0339) and cereal intake (OR: 0.658; 95% CI: 0.444–0.976; p = 0.0374) decreased the risk of DR. Salad/raw vegetable (OR: 6.540; 95% CI: 1.061–40.300; p = 0.0430) and fresh fruit consumption (OR: 3.573; 95% CI: 1.263–10.107; p = 0.0164) are risk factors for DN, while cereal consumption (OR: 0.380; 95% CI: 0.174–0.833; p = 0.0156) is the opposite. And genetically predicted higher pork intake increased the risk of DNP (OR: 160.971; 95% CI: 8.832–2933.974; p = 0.0006; FDR = 0.0153). The MVMR analysis revealed that cheese intake may act as an independent protective factor for DR development. Moreover, fresh fruit intake, salad/raw vegetable intake and pork intake may be independent risk factors for DR, DN and DNP, respectively. Other causal associations between dietary habits and DMCs risk may be mediated by intermediate factors.

Conclusion

This causal relationship study supports that specific dietary interventions may reduce the risk of DMCs.
Complementary food hygiene practice and associated factors among mothers with children aged 6–23 months in Dessie Zuria, South Wollo Zone, Amhara, Ethiopia, 2023
Authors: Addis Alemayehu Tesfaye , Dawed Yeshimebet Ali , Yimer Geleta Mussa , Adem Yonas Fissha
Published: November 2024

Background

Implementing appropriate complementary food hygiene practices is essential to lower the incidence of food-borne disease and malnutrition in children. However, this aspect is often overlooked in resource-limited settings, and information regarding these practices is not fully available and is not assessed enough. Therefore, this study aimed to assess complementary food hygiene practices and their associated factors in Dessie Zuria, South Wollo Zone, Amhara, Ethiopia, in 2023.

Methods

An institutional-based cross-sectional study design was conducted from 17 April to 18 May 2023, among 366 mothers with children aged 6–23 months. Dessie Zuria was purposively selected, and a systematic random sampling technique was used to recruit study participants. Data were collected using pretested and structured questionnaires. Finally, the data were entered using EPI-info and then exported to SPSS version 26. Bivariable and multivariable logistic regression analyses were used to identify factors associated with complementary feeding hygiene practices. Both crude odds ratios (COR) and adjusted odds ratios (AOR) with a 95% confidence level (CI) were computed, and a p-value of <0.05, in the final model, was considered statistically significant.

Results

The proportion of households practicing complementary food hygiene was 22.22%. Factors associated with these practices included access to media such as television or radio (AOR = 10.51, 95% CI: 2.8, 39.28), starting complementary feeding before 6 months (AOR = 2.01, 95% CI: 1.05, 3.84), and the child’s age being 6 to 11 months (AOR = 0.25, 95% CI: 0.08, 0.7).

Conclusion

The prevalence of complementary food hygiene practices was poor. Healthcare professionals should promote starting breastfeeding at the age of 6 months. In addition, media companies ought to make an effort to create a positive social and cultural environment that encourages complementary feeding practices for young children.
Relationship between HALP and PNI score with 1-month mortality after CABG
Authors: Koyuncu Ilhan , Koyun Emin
Published: November 2024

Background

Coronary heart disease (CHD) is the most common cause of cardiovascular disease (CVD). CHD is among the most common causes of mortality and morbidity world wide. In addition, CHD is one of the most important causes of health expenditures world wide. Today, coronary artery bypass grafting (CABG) operations are a widely used surgical procedure and have an important place in the treatment of CHD. Many scoring systems have been evaluated to estimate the risk of mortality and morbidity. 30-day mortality rates after CABG have been reported as 1–4% in large-scale studies.

Objectives

The aim of our study was to evaluate the relationship between 1-month mortality in patients undergoing CABG and the Hemoglobin, albumin, lymphocyte, platelet index (HALP score) and Prognostic nutritional index (PNI) calculated using laboratory data in the preoperative period.

Methods and design

A total of 239 patients who underwent CABG were evaluated retrospectively. Preoperative biochemical and hemogram values, demographic characteristics, comorbidities, HALP score and PNI values of the patients were recorded. The patients were divided into two groups: Exitus group (n = 51) and survival group (n = 188). The data of the two groups were compared, mainly HALP score and PNI.

Results

It was observed that 51 of 239 patients (21.3%) developed exitus during the 30-day follow-up after CABG. When demographic data are compared; advanced age, female gender, history of DM (Diabetes Mellitus), history of HL (hyperlipidemia) and smoking were found to be associated with mortality. When laboratory data are compared; high troponin levels, low hemoglobin, low lymphocyte and low albumin levels were found to be associated with mortality. Low HALP score (p < 0.001) and low PNI (p < 0.001) were also found to be associated with mortality. In univariate and multivariate regression analysis; advanced age, history of DM, HALP score and PNI were found to be independent predictors of 30-day mortality after CABG. It was determined that a cut-off value of 0.29 for the HALP score and 39.1 for PNI had found, respectively, 81 and 79% sensitivity and 82 and 80% specificity.

Conclusion

Preoperatively measured HALP score and PNI can be used to predict 1-month mortality after CABG.
A bibliometric study on clinical research in neonatal encephalopathy
Authors: Tan Shujun , Alimujiang Gulizuohere , Rejiafu Nuerya
Published: November 2024

This research presents a comprehensive review of studies on neonatal encephalopathy conducted between 2005 and 2024, utilizing knowledge graph analysis through CiteSpace and VOSviewer software. A search of the Web of Science core database identified 893 articles, with the United States emerging as a prominent contributor in terms of publication volume. Key co-occurrence keywords identified include “Hypoxic-ischemic encephalopathy”, “Neonatal encephalopathy”, and “Therapeutic hypothermia”. Notable contributors, such as Seetha Shankaran and Floris Groenendaal, have significantly advanced research in this area. Leading institutions in this field include the University of Washington, while the journal Pediatrics is recognized as a leading publication in the domain of neonatal encephalopathy. These findings provide a solid foundation for guiding future research endeavors.
Case report: Treatment with ensartinib shows good response to SQSTM1-ALK fusion in lung adenocarcinoma
Authors: Wang Pandeng , Jiang Zhuo , Guo Jianji , Liu Tao , Liu Zhen , Wang Dongdong , Li Honglin
Published: November 2024

Lung cancer is a prevalent malignancy, with the rearrangement of the anaplastic lymphoma kinase (ALK) gene being responsible for a minority of cases of non-small cell lung cancer (NSCLC). NSCLC patients harboring ALK fusion proteins demonstrate sensitivity to ALK tyrosine kinase inhibitors (TKIs). In this report, we describe the case of a female patient with metastatic lung adenocarcinoma, identified through NGS to carry a rare inverted SQSTM1-ALK (S5, A20) fusion. The patient received ensartinib as first-line therapy, resulting in a partial response (PR). At the time of publication, the patient’s condition remained favorable. We have, for the first time, identified the presence of SQSTM1-ALK fusion in pericardial effusion, with the favorable response to ensartinib validating the oncogenic potential of SQSTM1-ALK fusion. The substantial advancements and extensive utilization of NGS have facilitated the identification of rare fusion variants.