bluuebunny/crossref_metadata_2025 huggingface dataset:
Therapeutic Potential of Quercetin in Diabetic Neuropathy and Retinopathy: Exploring Molecular Mechanisms
Authors: Saikia Lunasmrita , Barbhuiya Sm Abdul Aziz , Saikia Kalyani , Kalita Pratap , Dutta Partha Pratim
Published: August 2024

:

Diabetes mellitus poses a significant health challenge globally, often leading to debilitating
complications, such as neuropathy and retinopathy. Quercetin, a flavonoid prevalent in
fruits and vegetables, has demonstrated potential therapeutic effects in these conditions due to its
antioxidant, anti-inflammatory, and neuroprotective properties. This review summarizes and provides
a comprehensive understanding of the molecular mechanisms underlying the efficacy of
quercetin in ameliorating diabetic neuropathy and retinopathy. A thorough search was carried out
across scientific databases, such as SciFinder, PubMed, and Google Scholar, to gather pertinent literature
regarding the effect of quercetin on diabetic neuropathy and retinopathy till February
2024. Preclinical studies indicate that quercetin mitigates neuropathic pain, sensory deficits, and
nerve damage associated with diabetic neuropathy by improving neuronal function, reducing
DNA damage, regulating pro-inflammatory cytokines, enhancing antioxidant enzyme levels and
endothelial function, as well as restoring nerve injuries. In diabetic retinopathy, quercetin shows
the potential to preserve retinal structure and function, inhibiting neovascularization, preventing
retinal cell death, reducing pro-inflammatory cytokines, and increasing neurotrophic factor levels.
Moreover, through modulating key signaling pathways, such as AMP-activated Protein Kinase
(AMPK) activation, Glucose Transporter 4 (GLUT 4) upregulation, and insulin secretion regulation,
quercetin demonstrates efficacy in reducing oxidative stress and inflammation, thereby protecting
nerve and retinal tissues. Despite promising preclinical findings, challenges, such as limited
bioavailability, necessitate further research to optimize quercetin’s clinical application in order
to establish its optimal dosage, formulation, and long-term efficacy in clinical settings.
Identification and Analysis of Differentially Expressed Genes Associated with Ferroptosis and HIV in PASMCs Based on Bioinformatics
Authors: Lu Tong , Guo Linna , Ma Yong , Yao Lijie , Li Li , Bian Wenshan , Xiu Miao , Jiang Yang , Li Yongtao , Jin Haifeng
Published: August 2024

Background:

HIV-associated pulmonary arterial hypertension (HIV-PAH), a rare and fatal
condition within the pulmonary arterial hypertension spectrum, is linked to HIV infection. While
ferroptosis, an iron-dependent cell death form, is implicated in various lung diseases, its role in HIVPAH
development remains unclear.

Methods:

Leveraging Gene Expression Omnibus data, we identified differentially expressed genes
(DEGs) in pulmonary arterial smooth muscle cells, including HIV-related DEGs (HIV-DEGs) and
ferroptosis-related HIV-DEGs (FR-HIV-DEGs). PPI network analysis of FR-HIV-DEGs using CytoHubba
in Cytoscape identified hub genes. We conducted functional and pathway enrichment analyses
for FR-HIV-DEGs, HIV-DEGs, and hub genes. Diagnostic value assessment of hub genes utilized
ROC curve analysis. Key genes were further screened, and external validation was performed.
Additionally, we predicted a potential ceRNA regulatory network for key genes.

Results:

1372 DEGs were found, of which 228 were HIV-DEGs, and 20 were FR-HIV-DEGs. TP53,
IL6, PTGS2, IL1B (downregulated), and PPARG (upregulated) were the five hub genes that were
screened. TP53, IL6, and IL1B act as ferroptosis drivers, PTGS2 as a ferroptosis marker, and PPARG
as a ferroptosis inhibitor. Enrichment analysis indicated biological processes enriched in "response
to oxidative stress" and pathways enriched in "human cytomegalovirus infection." Key genes IL6 and
PTGS2 exhibited strong predictive value via ROC curve analysis and external validation. The predicted
ceRNA regulatory network identified miRNAs (has-mir-335-5p, has-mir-124-3p) targeting
key genes and lncRNAs (XIST, NEAT1) targeting these miRNAs.

Conclusion:

This study advances our understanding of potential mechanisms in HIV-PAH pathogenesis,
emphasizing the involvement of ferroptosis. The findings offer valuable insights for future research
in HIV-PAH.
miR-124 in Neuroblastoma: Mechanistic Insights, Biomarker Potential, and Therapeutic Prospects
Authors: Monisha Kandegala Mahesh , Shivakumar Dhanu Annyaplar , Mutthuraj Dasegowda , Nandini Guruswamy , Muthusami Sridhar , Basalingappa Kanthesh M
Published: August 2024

:

Neuroblastoma, a malignancy predominantly affecting young children, originates from
neural crest cells in the sympathetic nervous system. It primarily appears in the adrenal gland but
can also affect nerve tissues in regions, such as the chest, neck, abdomen, and pelvis. Despite advancements
in treatment, high-risk neuroblastoma patients often face poor prognoses, underscoring
the need for ongoing research. This review paper examines the numerous factors responsible
for neuroblastoma, emphasizing the importance of approaching the disorder with more strategic
therapeutic methods. MicroRNAs, particularly miR-124, play critical roles in gene regulation and
cancer pathogenesis. Abundant in the brain, miR-124 functions as a tumor suppressor by inhibiting
cell growth, migration, and invasion and is often dysregulated in neuroblastoma. This study investigates
the molecular functions of miR-124 in neuroblastoma, its potential as a biomarker, and
its application in targeted therapy. MiR-124 regulates key pathways in neuroblastoma, including
PI3K/AKT, TGF-β, and p53 signaling, impacting cell proliferation, apoptosis, and metastasis. The
study also explores the promise of miR-124 as a biomarker for neuroblastoma through liquid biopsy,
enabling non-invasive diagnosis and disease monitoring. Therapeutic strategies targeting
miR-124 pathways show potential for overcoming chemotherapy resistance and improving treatment
efficacy. The research underscores the significance of miR-124 in neuroblastoma, aiming to
enhance early diagnosis, identify specific drug targets, and expand treatment options, ultimately
improving patient outcomes.
An Efficient Metal-Free Methodology for the Synthesis of Hydrazo-Linked 5-(4-aryl)-1H-1,2,4-Triazoles
Authors: Rani Neha , Aneja Deepak K. , Kinger Mayank , Soni Rinku , Sihag Monika , Malik Sandeep , Bhardwaj Kirti
Published: August 2024

Hydrazo compounds have displayed significant roles in both biological and physical aspects,
such as spinamycin as a potent growth inhibitor against fungi and rat sarcoma cells, hydrazo
tocopherol as a component of vitamin E, and electron-rich hydrazo-linked triazines as energetic materials.
In this study, a metal-free approach was proposed for the synthesis of hydrazo-linked 5-(4-
aryl)-1H-1,2,4-triazoles. The methods for the synthesis of 5-(4-aryl)-1H-1,2,4-triazoles initiated by
the reaction of aldehyde with semicarbazide. The resulted compound, 5-(4-aryl)-1H-1,2,4-triazol-3-
ol, upon reaction with phosphorous oxychloride yielded 3-chloro-5-(4-aryl)-1H-1,2,4-triazoles. These
synthesized compounds upon fusión with various aryl and hetero aryl substituted hydrazines provided
desired hydrazo moieties. Synthesized hydrazo compounds were characterized by spectroscopic
techniques, viz. 1H-NMR, FT-IR and mass spectrometry. In this study, a series of novel hydrazo-
linked 5-(4-aryl)-1H-1,2,4-triazoles were synthesized. The methodology proposed in this
study eliminates the use of complicated procedures and heavy metals.
The Therapeutic Potential of Ganoderma lucidum Karst and Ziziphus jujuba Mill for Postsurgical Adhesion Band Formation
Authors: Khalili-Tanha Ghazaleh , Nazari Seyedeh Elnaz , Asgharzadeh Fereshteh , Mobasheri Leila , Babaei Maryam , Naimi Hamideh , Maftooh Mina , Hassanian Seyed Mahdi , Eskandari Moein , Askarnia-Faal Mohammad Mostafa , Alaei Maryam , Ghorbani Hamid Reza , Aliakbarian Mohsen , Ferns Gordon , Khazaei Majid , Avan Amir
Published: August 2024

Background:

Intra-abdominal adhesions are a commonly occurring postoperative complication
following abdominopelvic surgery. Peritoneal adhesion formation can lead to infertility,
chronic pelvic pain, and intestinal obstruction. The anti-inflammatory and anti-oxidant activities of
Ganoderma lucidum Karst (G. lucidum) and Ziziphus jujuba Mill (Z. jujuba) have been reported.
Here, we have explored the therapeutic potential of Ganoderma lucidum Karst (G. lucidum) and Z.
jujuba against postsurgical adhesion band formation. The NC3Rs ARRIVE guidelines were followed
during experimental studies.

Methods:

G. lucidum powder (800 mg/kg) and Z. jujuba powder (400 mg/kg) were administered
using oral gavage to different groups of male albino Wistar rats. After ten days of treatment, macroscopic
evidence for peritoneal adhesions and adhesion band score were determined. Furthermore, the
anti-inflammatory and antifibrosis effects of G. lucidum and Z. jujuba were assessed using histopathology,
ELISA, and real-time polymerase chain reaction methods. Also, alterations in some oxidative
stress parameters were evaluated.

Results:

G. lucidum and Z. jujuba significantly decreased adhesion bands and were associated with a
reduction in inflammatory cell infiltration into damaged tissues and the mRNA and protein expression
of inflammatory cytokines via modulation of TNF-α, IL-6, IL-1β, and TGF-β. Moreover, both
agents inhibited fibrotic adhesion band formation by decreasing collagen deposition and reducing
profibrotic marker expression, Col1A1, at the peritoneum adhesion tissues. G. lucidum and Z. jujuba
improved some antioxidant factors in rats’ adhesion tissues. The result of LC-MS showed that
Ganoderma lucidum Karst and Ziziphus jujuba Mill consist of components with antioxidant activity,
including ganoderic acid, lucidenic acid, quercetin, linoleic acid, malic acid, and benzoic acid.

Conclusion:

The results have demonstrated the therapeutic potential of G. lucidum and Z. jujuba in
reducing peritoneal adhesion through anti-inflammatory and anti-fibrotic properties, indicating their
promising value as a new therapeutic approach in preventing postsurgical adhesion.
New Approach as Inhibitor Against Head-Neck Cancer by In silico, DFT, FMOs, Docking, Molecular Dynamic, and ADMET of Euphorbia tirucalli (Pencil Cactus)
Authors: Al Mashud Md. Abdullah , Devnath Ramprosad , Anzuman Masuma , Sumona Mahbuba Iasmin , Hossain Md. Shamim , Kumer Ajoy , Talukder Md. Enamul Kabir , Rahman Md. Mashiar , Imon Raihan Rahman , Akash Shopnil , El Moussaoui Abdelfattah , Salamatullah Ahmad Mohammad , Bourhia Mohammed
Published: August 2024

Background:

Head and neck cancer (HNC) is on the rise worldwide, endangering lives and straining
healthcare systems in both developing and developed nations. Despite the availability of a number of therapy
options, the success rate for treating and controlling head and neck cancer remains dismal. To combat the aggressiveness
and drug resistance of Epstein-Barr virus (EBV)-positive Head-Neck cancer cells, this study looks
into the potential of Euphorbia tirucalli (pencil cactus) leaf extract.

Objectives:

The goal of this study is to identify prospective therapeutic candidates from the extract of Euphorbia
tirucalli (pencil cactus) leaves, which have the ability to inhibit Epstein-Barr virus (EBV)-positive Head-
Neck cancer cells.

Materials and Methods:

The thirteen most important chemical components found in Euphorbia tirucalli (pencil
cactus) leaves were analyzed by means of molecular modeling techniques such as Absorption, Distribution,
Metabolism, Excretion, and Toxicity (ADMET), Quantum Mechanics (QM) calculation, molecular docking,
and molecular dynamics (MD) simulations. Using the Prediction of Activity Spectra for Substances (PASS)
model, we assess the potency of these compounds. Important molecular properties such as chemical potential,
electronegativity, hardness, and softness can be determined with the use of quantum chemical calculations employing
HOMO-LUMO analysis. These drugs' safety and toxicological characteristics are better understood to
assessments of their pharmacokinetics and ADMET. Finally, molecular dynamics simulations are employed to
verify binding interactions and assess the stability of docked complexes.

Results:

The molecular docking analysis identifies ligands (01), (02), and (10) as strong competitors, with
strong binding affinity for the Epstein-Barr virus (EBV)-positive Head-Neck cancer cell line. Not only do the
ligands (01), (02), and (10) match the criteria for a potential new inhibitor of head-neck cancer, but they also
outperform the present FDA-approved treatment.

Conclusion:

Taraxerol, euphol, and ephorginol, three phytochemicals isolated from the leaves of the Euphorbia
tirucalli (pencil cactus), have been identified as effective anti-cancer agents with the potential to serve as a foundation
for novel head-neck cancer therapies, particularly those targeting the Epstein-Barr virus (EBV)-overexpressing
subtype of this disease. An effective, individualized treatment plan for head-neck cancer is a long way off, but this
study is a major step forward that could change the lives of patients and reduce the global burden of this disease.
Insights into Suture Stem Cells: Distributions, Characteristics, and Applications
Authors: Wu Xiayanran , Zhou Xueman , Zhu Yufan , Zhang Zhenzhen , Dong Yanhua , Wang Jun , Liu Jin
Published: August 2024

Stem cells play an indispensable part in bone formation, homeostasis, and regeneration.
The origin of skeletal stem cells (SSCs) in long bones has been extensively discussed, and the major
cell population is considered to reside in the perivascular niche of the bone marrow. Cranial
bones are distinct from long bones in both the origins of their cell lineage and the manner of osteogenesis.
Recently, multiple tissue-resident craniofacial stem cell populations have been identified,
among which cranial suture-derived stem cells, known as suture mesenchymal stem cells (SuSCs),
exhibit unique biological characteristics. Whether SuSCs have potential therapeutic uses to repair
cranial bone defects and alleviate congenital skeletal diseases, represented mainly by
craniosynostosis, is a question of great research value. This review focuses on craniofacial stem
cells, especially SuSCs, with the goal of summarizing the latest progress as well as giving insight
into their regulatory molecular mechanisms and potential therapeutic targets.
The Role of Mycorrhizal Fungi in Orchids
Authors: Kaur Saranjeet , Deb Akash
Published: August 2024

Background:

In nature, orchid plants are obligate myco-heterotrophs, and rely
on mycorrhizal nutrient resources to grow and sustain in the wild, until they become
physiologically active photosynthetic plants. Their seeds lack nutrient reserves and receive
the necessary carbon from symbiotic fungi during germination. A mycorrhizal fungus
provides nutrients, especially sugars, as well as water to the corresponding host plant.
The range and distribution of orchid mycorrhizal fungi influence the survivability of orchid
populations in their natural habitats. Mycorrhizae form symbiotic connections with
the parenchymatous tissues of the roots of orchid plants. That the symbiotic orchid
mycorrhiza can invade through roots of orchid seedling, raised in vitro, has been patented.

Objective:

The objective of this study was to examine the presence of mycorrhiza in the
roots of Aerides multiflora during the vegetative phase

Methods:

Fresh roots were hand-sectioned, and thin sections were observed under the
microscope to locate the presence of mycorrhiza. Simultaneously, to observe the expansion
of mycorrhiza in the cortical region.

Results:

During the vegetative phase of plant growth, a peloton-like structure forms within
the cortical region of the orchid roots. Mycorrhizae was observed to be distributed
throughout the cortical layer of the root.

Conclusion:

This communication reviews the role of mycorrhiza in orchid plants.
The Landscape of Products for Diabetic Peripheral Neuropathy: A Scientific and Patent Systematic Review
Authors: dos Santos Barros Giselda , dos Passos Menezes Paula , de Cassia Silva Simone , da Silva Gabriel Francisco
Published: August 2024

Background:

Diabetic peripheral neuropathy (DPN) is a complication of diabetes
that occurs in 40 - 60 million individuals worldwide and is associated with other
chronic diseases. However, there are no review studies that present the state-of- the- art
and technologies developed to circumvent this important health problem.

Material and Methods:

This review was conducted based on scientific papers and patents.
The papers were retrieved from Lilacs, PubMed, and Web of Science databases,
and the patents from INPI, ESPACENET, WIPO, and GOOGLE PATENTS. Thus, a
sample consisting of 14 scientific articles and 667 patents was analyzed.

Results:

From the analysis of the data, we drew an overview of the development of biomedical
technologies for DPN and detected the pioneering spirit of China, the USA, and
Japan in the area, with a focus on the treatment of DPN. Based on this, we carried out a
SWOT analysis to help direct future efforts in the area, which should focus primarily on
developing technologies for prevention, early diagnosis, and, above all, cure of the disease
to reduce the important impact of this disease in various sectors of society.

Conclusion:

This study finds a concentration of diabetic peripheral neuropathy products,
especially therapeutic drugs, in high-income countries. It highlights the need for global
collaboration and strategic focus on therapeutic adherence and preventive strategies to
effectively manage DPN.
Horizontal Augmentation Using Customized Zirconia Membrane: A Case Report
Authors: Albash Ziad , Abdallah Yamen , Moawad Shadi , Khalil Ali , Assad Mounzer , Noureddin Hassan
Published: August 2024

Background

Horizontal bone defects are frequently observed after tooth extraction, primarily resulting from the physiological resorption of the alveolar ridge. Reconstruction of horizontal defects is essential before or during dental implant placement, particularly in the esthetic zone. This case report aims to evaluate the effectiveness of horizontal alveolar ridge augmentation utilizing a customized zirconia membrane.

Case Presentation

A 20-year-old female patient desired to replace the missing right upper central incisor with a dental implant. The radiographic evaluation showed a concave bone defect, which makes it impossible to place a dental implant. The treatment plan was made for localized ridge augmentation using a customized zirconia membrane (CZM) prior to dental implant placement.

Conclusion

The customized Zirconia membrane is an effective and very satisfactory treatment option in the management of horizontal defects. Customized zirconia membranes reduce surgical time, facilitate the procedure for the patient and the practitioner, reduce the rate of complications, and achieve good horizontal bone gain.
Mental Health Issues Among Adolescents: Challenges and Management
Authors: Kumar Saurabh , Kumar Krishan , Avti Pramod , Anand Akshay
Published: August 2024

Adolescence is an important stage of life between childhood and adulthood. The
shift in lifestyle, physical inactivity, high expectations of family/friends/teachers, and continuous
exposure to social media and the internet have created physical, social, emotional, and
mental imbalances in adolescents. The individuals of this age group are vulnerable and exposed
to these stressful factors, leading to psychological complications. Most psychological problems
diagnosed in the later stages of life begin in adolescence. The purpose of this mini-review was
to identify mental health problems and available non-pharmacological interventions to manage
the overall well-being of adolescents. A literature search was conducted to identify relevant
studies, including research, review, and other articles/data available on PubMed, Google
Scholar, ScienceDirect, WHO, GHDx, and AACAP. Search keys included essential keywords
like adolescence, yoga, mental health, anxiety, depression, and a combination of these words.
The literature search identified several mental disorders like emotional, behavioral, identity,
psychosis, dietary, and other risky behaviors. Most of these non-pharmacological interventions
adopted focused on improving the mental and physical well-being in school and community
settings. Among all the interventions, we found yoga to be the most popular and widely accepted
effective tool that reduces anxiety, depression, and psychological problems. Yoga also improved
resilience, attention, and other well-being parameters. Yoga helps manage physical and
mental health in adolescence.
Structure and Bonding
Authors: Bansal Anshul
Published: August 2024

This chapter delves into the foundational concepts of chemical structure and
bonding, essential for understanding molecular interactions and properties. The chapter begins
with hybridization, exploring how atomic orbitals combine to form hybrid orbitals, influencing
molecular geometry and bonding properties. Bond length and bond angles are analyzed,
providing insight into the spatial arrangements and distances between atoms in molecules,
which are crucial for predicting molecular shape and reactivity. The concept of bond energy is
introduced, highlighting the energy changes associated with bond formation and dissociation,
essential for thermodynamic and kinetic considerations.The chapter then focuses on localized bonds and their impact on molecular stability and
reactivity, contrasting them with delocalized electrons in various bonding scenarios. Van der
Waals forces are examined as weak intermolecular forces that play significant roles in physical
properties such as boiling and melting points. The chapter proceeds with an analysis of the
inductive effect and the electromeric effect, both of which describe electron shifts within
molecules under the influence of electronegativity and external fields, respectively.Resonance and hyperconjugation are covered as mechanisms for electron delocalization,
contributing to molecular stability and influencing chemical reactivity. Hydrogen bonding, a
critical intermolecular force, is discussed in terms of its formation, significance in biological
systems, and effects on physical properties. Lastly, the concept of aromaticity is introduced,
explaining the unique stability and reactivity of aromatic compounds due to delocalized πelectrons in cyclic structures.
This comprehensive exploration of structure and bonding provides a detailed understanding of
the intricate forces and interactions that determine the behavior of molecules, laying the
groundwork for advanced studies in chemistry and related fields.
ANALISIS PERBANDINGAN KINERJA KEUANGAN SEBELUM DAN SESUDAH PENERAPAN MOBILE BANKING
Authors: Siagian Kevin Adriel , Manzilati Asfi
Published: August 2024

The purpose of this study is to identify financial performance differences of Bank Negara Indonesia before and after the application of Mobile Banking. This research period is six years before (2010 – 2015) and six years after (2016 – 2021) implementation of Mobile Banking. Financial performance was analyzed from the aspects of capital (CAR), productive assets (NPL), profitability (ROA), efficiency cost (OER), and liquidity (LDR). Normality test showed that CAR and NPL was tested using Paired sample t-test. Meanwhile ROA, BOPO, and LDR were tested using Wilcoxon signed-rank test. SPSS 25 was used for data processing. This study finds that OER does not show difference in financial performance before and after application of Mobile Banking. In NPL, there’s a slightly decreased after Mobile Banking application, considered as insignificant. CAR and LDR indicate an increase in financial performance. ROA significantly decreased after the application, which caused by high cost of application development and short period of the research. This study recommends banking companies, particularly Bank Negara Indonesia, to promote activation of Mobile Banking. Furthermore, security issues are crucial for both public and banks. Implementing proactive cybersecurity, policy harmonization, and increasing people awareness concerning cyberattack can serve protection for both banks and customers.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI EFEKTIVITAS PENYALURAN KREDIT MODAL KERJA TERHADAP USAHA MIKRO KECIL DAN EKSISTENSI LEMBAGA KEUANGAN (Studi Bank BPR Jatim Kantor Cabang Mojokerto)
Authors: Olfianita Firda
Published: August 2024

This research discusses factors influencing the effectiveness of working capital loan distribution on micro and small businesses and the existence of Bank BPR Jatim of Mojokerto branch office as one of financial institutions in Indonesia. This study uses causal relationships between the independent and dependent variables. Here two models are used. The first model is for the effectiveness of the bank in distributing working capital loan, and the second model is for the bank’s existence. The first model results in that the distribution of working capital loan by the bank influences the revenue of micro and small businesses, while assistance provided by the bank and economic condition do not influence the businesses revenue. The second model indicates that the institution’s capacity and public demand influence the bank’s existence, while regulation does not influence it. The findings can be used in designing policies and strategies to improve the development of Bank BPR Jatim of Mojokerto branch office in particular and the improvement of Indonesian financial institutions in general, through which the institutions can have the capability to maintain their existence sustainably and widely and can empower business owners especially in micro and medium sector.
PENGARUH RASIO KESEHATAN BANK TERHADAP PENYALURAN KREDIT MODAL KERJA PADA USAHA MIKRO, KECIL DAN MENENGAH (UMKM) DI MASA PANDEMI COVID-19
Authors: Veronica Amalia Maike
Published: August 2024

Banking as an intermediary institution whose task is to collect funds from the community and channel it back to the community in the form of credit. In distributing credit, there are internal bank factors such as bank health that must be considered, which can be seen from several ratios such as CAR, LDR, NPM, BOPO, ROA, and NPL. This study aims to examine the effect of banking health ratios on the distribution of working capital loans to MSMEs during the Covid-19 pandemic. The object of this research is banking which is included in the list of BUKU for the period 2019-2021. The research sample used was 15 banking companies. This type of research is explanatory research with quantitative research methods. Based on the results of the study, it was shown that during the study period the CAR variable, LDR had a significant positive effect and NPL had a significant negative effect on the distribution of working capital loans to MSMEs. Meanwhile, simultaneously, all variables have a significant effect on the distribution of working capital loans to MSMEs with a magnitude of effect of 0.994106 or 99.41%. Some banking ratios are still in a stable condition even though the economy is weakening due to the pandemic, this is a strategic step for the government and banks, one of which is to maintain the quality of lending.
ANALISIS FLYPAPER EFFECT PADA PAD DAN DAU TERHADAP BELANJA DAERAH KABUPATEN/KOTA DI KIB DAN KIT
Authors: Trisyanti Dela Irbah , Putu Mahardika Adi Saputra
Published: August 2024

This study aims to determine whether there is the flypaper in the western region of Indonesia and eastern region of Indonesia. This study uses a quantitative approach with Fixed effect model (FEM) as its method. This study uses secondary data that obtained through DJPK Ministry of Finance’s website to get Local Own-source Revenue (LOR), General Allocation Fund (GAF), Regional Expenditure and Central Bureau of Statistics to get population that used as control variable during the 2010-2020 period. The result of this study indicate that LOR, GAF, and population has a positive effects on regional expenditures. The flypaper effect also occurs in the western region of Indonesia and eastern region of Indonesia
DAMPAK KEBIJAKAN PEMBERLAKUAN PEMBATASAN KEGIATAN MASYARAKAT (PPKM) DARURAT TERHADAP REAKSI PASAR SAHAM SEKTOR KESEHATAN (HEALTHCARE) PADA BURSA EFEK INDONESIA: SEBUAH PENDEKATAN EVENT STUDY
Authors: Kezia Gabrielle  , Shofwan
Published: August 2024

This study aims to examine the information content contained in the announcement of the emergency Community Activity Restrictions policy announcement on July 1, 2021 which was carried out by analyzing abnormal returns and trading volume of healthcare sector activity in the period surrounding the event. This research is a quantitative research with an event study approach. The data analysis tool used to test the hypothesis in this study is the one sample T-test statistical test on the abnormal return indicator and the Paired sample t-test on the trading volume activity indicator. The results of the t-test indicate that there is a positive abnormal return on the main board stocks, thus proving that the market responds to the event as good news. Meanwhile, on the development board stock, there is an abnormal return that has a negative value, thus proving that the market responded to the event as bad news. It can be concluded that the healthcare sector stock market responds to the emergency PPKM announcement differently according to the characteristics of the stock listing board. The results of the different Paired Sample T-test on the average trading volume activity (ATVA) indicator before and after the emergency PPKM announcement show that there are differences in ATVA on the main board and development board stocks. This difference may be caused by the behavior of investors who sell or buy stocks in the health sector based on the category of the stock listing board
ANALISIS PENGARUH INKLUSI KEUANGAN TERHADAP KEMISKINAN DI INDONESIA
Authors: Prakarsa Daffa Yudha , Bintoro Nugroho Suryo
Published: August 2024

Poverty still a major problem in developing countries, including Indonesia. Various efforts have been made to alleviate poverty, one of which is through financial inclusion. This research attempts to identify and analyze the effect of financial inclusion on poverty in Indonesia. This research uses panel data from 34 provinces in Indonesia during 2018-2021. The regression model used is panel data regression. Testing the hypothesis with t test and F test. The results showed that the financial inclusion dimension of accessibility has a negative and significant effect, the financial inclusion dimension of availability has a negative and insignificant effect, and GRDP per capita has a negative effect although not significant on poverty in 34 provinces in Indonesia. Meanwhile, the financial inclusion dimension of use has a positive and significant effect on poverty in 34 provinces in Indonesia. This indicates that the use of financial services can actually increase poverty in 34 provinces in Indonesia. Financial inclusion dimensions of the use of financial services are still minimal for the poor. So that increasing the use of financial services must pay attention to the poor. The government also needs to pay attention to increasing financial inclusion which is more evenly distributed between provinces.
ANALISIS REAKSI PASAR TERHADAP KEBIJAKAN STOCK SPLIT SEKTOR PERDAGANGAN, JASA, DAN INVESTASI TAHUN 2016 - 2021
Authors: Aldila Exi , Kaluge David
Published: August 2024

This study aims to examine market reactions caused by stock split events in the trade, service and investment sectors from 2016 to 2021. This study used 13 sample companies with 5 sub-sectors as measured by the variables Trading Volume Activity, Abnormal Return and Share Transaction Value. The analysis technique used is event windows by comparing data 5 days before and 5 days after the stock split event. The analytical method used in this research is descriptive analysis, Kolmogorov-Smirnof normality test, Paired Sample T-test hypothesis testing. From these tests, the results show that there is no significant difference in Trading Volume Activity and Share Transaction Value and the data remains the same between before and after the stock split. In contrast to Abnormal Return experiencing significant differences with a decreasing probability value. This shows that the stock split event that occurred received a negative response from the market as evidenced by a decrease in Abnormal Return and no change in Trading Volume Activity and Share Transaction Value.
PENGARUH DANA PIHAK KETIGA (DPK), CAPITAL ADEQUACY RATIO (CAR), NON PERFORMING LOAN (NPL), NET INTEREST MARGIN (NIM), DAN LOAN TO DEPOSIT RATIO (LDR) TERHADAP PENYALURAN KREDIT
Authors: Sudimoro Family Syafira Tauhida Qulby
Published: August 2024

Banking is an important part that plays a role in the economic development of a country. Banking also functions as an intermediary institutions whose job is to collect funds from the public and channel them back to the community in the form of credit. In extending credit, there are internal factors that must be considered, namely the activities of banks collecting public funds are indicated by the amount of DPK, from the capital side it is indicated by CAR, the level of collectibility is indicated by NPL, the level of bank operational efficiency is indicated by NIM, and from a banking liquidity perspective indicated by LDR. This study aims to determine the effect of Third Party Funds (DPK), Capital Adequacy Ratio (CAR), Non Performing Loans (NPL), Net Interest Margin (NIM), and Loan to Deposit Ratio (LDR) on bank lending listed on the Stock Exchange. Indonesian securities for the 2012-2021 period using the purposive sampling method. The analytical method uses panel data regression. The results showed that DPK, CAR, NIM, and LDR had a positive and significant effect on lending. Meanwhile, NPL has a significant negative effect on lending.
Keywords: Lending, DPK, CAR, NPL, NIM, LDR
DIGITALISASI DAN PENGANGGURAN DI PEDESAAN JAWA TIMUR PADA MASA PANDEMI COVID-19 (STUDI KASUS PADA SEKTOR INFORMAL)
Authors: Mawarni Sherina Indah , Syafitri Wildan
Published: August 2024

The COVID-19 pandemic has caused unemployment  increase, but COVID-19 has also provided a digital acceleration boost. In 2020 East Java has highest rate of digital literacy. Using SAKERNAS 2020 data, This study employs logistic regression to determine how East Java's unemployment is affected by digitalization. This study indicated that East Java's unemployment rate was significantly and negatively impacted by digitization. Workers who can master information technology through use of the internet will have an impact on have a smaller tendency to become unemployed than those who cannot use the internet. In addition, other factors such as area of residence, employment sector, gender, training, pre-employment card ownership, education and migration also affect the tendency of the workforce to become unemployed.
ANALISIS PERILAKU HERDING PADA SAHAM SEKTOR BANK DIGITAL YANG TERDAFTAR DI BEI PERIODE 2021
Authors: Priscillia Anita , Vietha Devia SS
Published: August 2024

This research was conducted to detect and identify herding behavior that might occur in digital bank sector stocks in the 2021 period. The 2021 period is used for the market when market conditions are stressful and high returns. The approach method of Chang et al. (2000), namely CSAD-Cross Sectional Absolute Deviation to calculate return dispersion values ​​and use quantile regression analysis to detect herding behavior. The data used is secondary data, in the form of monthly stock return data and market returns for digital bank stocks. The results of this study indicate that digital bank stocks in 2021 have no indication of herding behavior. This means that Indonesian investors acted rationally during the COVID-19 pandemic.
PENGARUH FAKTOR SPESIFIK BANK TERHADAP RISIKO KREDIT PERBANKAN PADA MASA PANDEMI COVID-19
Authors: Amani Alhaura Annisa , Al Muizzuddin Fazaalloh
Published: August 2024

The impact of the spread of the Covid-19 virus has affected the Indonesian banking sector, one of which is increasing credit risk. Therefore, this study aims to determine the effect of Income Diversification (DIV), Capital Adequacy Ratio (CAR), BOPO and Bank Size (SIZE) on Credit Risk (NPL) during the Covid-19 pandemic. The method of data analysis in this study uses the panel data regression method. The subjects in this study are banks that are included in the KBMI 4 category. The research data is sourced from the quarterly published reports of each bank from 2020:1 to 2022:3. The results of this study indicate that all independent variables can explain the dependent variable by 75.86% while the rest are influenced by other variables. Partially, income diversification has a negative effect on NPL. Capital Adequacy Ratio (CAR), and BOPO have a positive effect on NPL. Meanwhile bank size (SIZE) has no effect on NPL.
PENGARUH MAKROEKONOMI DAN KINERJA KEUANGAN TERHADAP NILAI PERUSAHAAN BANK DIGITAL SELAMA PANDEMI COVID-19
Authors: Utami Aulia Putri , Hascayani Tyas Danarti
Published: August 2024

The increase in stock prices is considered to be an indicator of increasing firm value. During the pandemic, there was a contradiction between stock price movements and the fundamental conditions of digital banking companies. This research was conducted to determine the effect of macroeconomics as reflected by gross domestic product (GDP), interest rates (R), exchange rates (NT), inflation (INF), and the effect of financial performance as reflected by return on assets (ROA) and loan to deposit ratio (LDR) to firm value (MBV) of digital banks during the Covid-19 pandemic. 48 samples from 6 companies with 8 time periods moving quarterly from 2020-2021 were analyzed using multiple linear regression panel data with the selected common effect model (CEM). The results of this study are PDB and R have a positive and significant effect on MBV, while NT, INF, LDR have a negative and significant effect on MBV. And only ROA has a positive and insignificant effect on MBV. However, simultaneously all the dependent variabels have a significant effect on MBV.
BEHAVIORAL INTENTION TO USE MOBILE BANKING IN GENERATION Z
Authors: Angelica Mora Argatha , Satria Dias
Published: August 2024

The objective of this study is to identify, explore, and increase understanding of the key factors influencing Generation Z's intention to use mobile banking. This study surveyed 100 respondents aged 17-26 in Jakarta, Indonesia, using an online questionnaire. The Partial Least Square Structural Equation Modeling (PLS-SEM) method was employed to identify the key factors influencing Generation Z's behavioral intention to use mobile banking. The research findings reveal a relationship between perceived trust, self-efficacy, and social influence in the context of behavioral intention based on the Unified Theory of Acceptance and Use of Technology (UTAUT) framework. However, the perceived risk was found to have an insignificant negative influence. The results provide valuable insights for banks in Jakarta in developing policies and innovations to improve the quality of the financial system.
STUDI KOMPARATIF PROFITABILITAS SEBELUM DAN SESUDAH PENERAPAN BRANCHLESS BANKING DAN DAMPAK TERHADAP KEUANGAN BERKELANJUTAN
Authors: Pranata S. Andika Nedya , Sakti Rachmad Kresna
Published: August 2024

The purpose of this study was to determine a comparative study of banking profitability before and after implementing branchless banking, as well as analyzing the impact of the branchless banking program on sustainable finance. This research takes bank companies that are included in the Bank Based on Core Capital (KBMI) 4 group, namely Bank Mandiri, BRI, BNI, and BCA as research objects. Apart from that, one of the impacts of branchless banking on the macro economy is economic growth. The time period reviewed in this research is from 2010-2014 before the use of branchless banking and 2015-2022 after the use of Branchless Banking. This research uses a comparative test method and the hypothesis test uses non-parametric statistics (Wilcoxon signed-rank test). The research results show that in the ROA ratio there are 3 banks that show significant differences, in the NIM ratio there are 3 banks that show significant differences, and in the BOPO ratio 2 banks show significant differences. The results of this research also show that the existence of branchless banking has a positive impact on the macro economy, namely economic growth in
THE EFFECT OF INCOME AND ELECTRONIC MONEY ON CONSUMPTION BEHAVIOR OF STUDENTS UNDERGRADUATE ECONOMIC FINANCE AND BANKING UNIVERSITAS BRAWIJAYA
Authors: Zanuadewi Mellania Putri , Bintoro Nugroho Suryo
Published: August 2024

This research was conducted to determine the effect of Income and Electronic Money (E-Money) on Consumption Behavior. This data specifically takes students of Economics, Finance and Banking, Universitas Brawijaya (Class of 2019 - 2021). This study uses a quantitative approach. The sampling method used in this research is purposive sampling. The method used in this study is the Partial Least Square (PLS) method with the SMARTPLS 3.0 tool. The sample of this study is 289 students who use E-money as a medium of exchange. And the results of the analysis show that the income variable has no significant effect on consumption behavior. Meanwhile, Electronic Money has a significant effect on Consumption Behavior of Students of S1 Economics, Finance and Banking, Universitas Brawijaya
PENGARUH MAKRO EKONOMI TERHADAP RETURN SAHAM PERBANKAN
Authors: Muhammad Alfin Syaichul Farich  , Yenny Kornitasari
Published: August 2024

This study aims to see the effect of economic variables and world oil prices on banking stock returns. The method used in this study is a panel data regression analysis technique using quarterly data and the period from 2020 to 2022. The results of the research show that inflation and interest rates have a significant positive effect on banking stock returns, an increase in inflation causes people to reduce consumption and prefer to invest their money in the capital market, an increase in interest rates can result in an increase in income which has an impact on banking profits and performance, this is interesting investors' interest in investing in banking shares. Meanwhile, the exchange rate has a significant negative effect on banking stock returns, an increase or depreciation of the Rupiah exchange rate causes an increase in production costs and company expenses which can reduce company performance. so that investors become less interested in investing in the stock market. Meanwhile, world oil prices have no effect on banking stock returns
PENGARUH STRUKTUR MODAL TERHADAP PROFITABILITAS BANK PADA DUAL BANKING SYSTEM DI INDONESIA
Authors: Wu Cherrin Nathania , Indraswari Citra Rahayu
Published: August 2024

The dual banking system in Indonesia still faces the problem of inadequate capitalization with a high level of leverage. This study aims to analyze the effect of capital structure on bank’s profitability in Dual Banking System in Indonesia. The data analysis method used is panel data regression and difference test on 8 conventional banks and 8 Islamic banks. Panel data regression is intended to identify the influence of capital structure proxied through DER and CAR ratios on profitability (ROA) with control variables of bank size and asset’s growth. The secondary data used is annual report data for the period 2013-2022 sourced from OJK. The estimation results on conventional banking show that the DER and growth variable has a significant positive impact on profitability, while CAR and bank size have no significant influence on profitability. Then, in Islamic banking, DER has a significant negative influence on profitability performance, while CAR and growth have no significant influence on Islamic bank’s profitability performance. Meanwhile, bank size is proven to affect the Islamic bank’s profitability performance. Through a t-test, there is a significant difference in profitability performance and capital structure between the two banking systems in Indonesia.
PENERAPAN STATISTICAL QUALITY CONTROL DALAM PENGENDALIAN MUTU PRODUKSI SNACK EGGROLL
Authors: Anggraeni Rila , Izza Navisah Ainul
Published: August 2024

The processing industry is an industry that plays a major role in Indonesia's economic growth where the food and beverage sub-sector is the most dominating. Intense competition in the food industry encourages businesses to continue to innovate and control quality by reducing defects. Barin Food is an SME in Malang producing processed food distinctive to Malang; eggroll is one of its featured products. In the first quarter of 2022, it is recorded that 6831 pieces of vanilla eggroll were broken. The company has not used any instrument to control product quality. The goal of this study is to apply Statistical Quality Control method to minimize broken product in the company using histogram, Control Chart, and Fishbone Chart. The results of the analyses show that the company needs to suppress the number of broken products. The cause of the flaws is divided into four: human, machine, material, and environment. The result of the SQC analysis suggest the renewal of production machines.
ANALISIS PENERAPAN STRATEGI COST TRANSPARENCY PADA USAHA COFFEE ROASTERY
Authors: Haritz Ahmad Nauval , Susilowati Christin
Published: August 2024

Business competition in coffee industry is increasing in every year. Coffee consumption and production in Indonesia have been increasing drastically during the last five years. It has also been recorded that the number of coffee shops tripled only from 2016 to 2019. Therefore, coffee businesses need to apply different strategies in order to stay exist and competitive. This research was conducted at Langgan Coffee Roasters, a business that uses cost transparency whose main activities are roasting and selling coffee beans through subscription. The goal of this study is to identify how the strategy is applied and how their customers respond to it. The data of this research was harvested through interviews, observations, and documentations. This study finds that cost transparency is applied by opening the cost structure that constitutes the product to the public through Google Sheets. Their customers respond to it well since they can get better product knowledge and can make better budget planning before making transaction. Then, as they trust the company more, both parties have a closer relationship.
PENGARUH ORIENTASI KEWIRAUSAHAAN, INOVASI RADIKAL, DAN STRATEGI BISNIS TERHADAP KINERJA PERUSAHAAN
Authors: Adyuta Hafizh Rakha , Prabandari Sri Palupi
Published: August 2024

The purpose of this study was to determine the effect of entrepreneurial orientation, radical innovation, and business strategy on company performance. The population in this study, namely handicraft SMEs in the city of Malang returned to 209, while the sample of this study was micro, small and medium enterprises engaged in handicrafts in the city of Malang. Determination of the number of samples using the Slovin formula with an allowance of 0.1 and obtained as many as 100 samples. The method used in this study is a quantitative method with Multiple Linear Regression Analysis using SPSS 25 Software. The sampling technique uses simple random sampling and gets 100 respondents who are distributed both through online and offline questionnaires. The results showed that entrepreneurial orientation, radical innovation, and business strategy had a positive and significant effect on purchasing decisions. In the research application variables, handicraft SMEs in Malang City are good, but each variable needs to be developed to get maximum performance.