bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Electrically Assisted Preheating on Microstructure and Properties of Laser-Cladded Co-Based Coating on CP-Ti Alloy Substrate
Authors: Li Xiao , Peng Jiahui , Wang Fei , Liu Zengzhi , Feng Xinyi
Published: August 2023

Co-based coatings were prepared on commercially pure titanium (CP-Ti) with electrically assisted pre-heating (EAPH), followed by laser cladding with the assistance of pulsed current. Conventional pre-heating (CPH) laser cladding was carried out as a control to investigate the effects of a pulsed current on the phase composition, microstructure, microhardness, and wear resistance of the coatings. The results showed that periodically varied pulsed currents generate an induced magnetic field. This field fragments bottom dendrites and transforms columnar dendrites into equiaxed crystals through the influence of the Lorentz force. The phase composition of the coatings remained unchanged under the pulsed current, as well as unassisted and CPH condition, consisting of γ-Co, α-Ti, CoTi2 solid solution, and TiC, Cr7C3 hard phases. The microhardness of the coating increased at 720 A due to grain refinement, compared to unassisted and preheated coatings at the same temperature. Moreover, a suitable preheating temperature can reduce crack generation and improve the wear properties of the coating.
A New Mineral Hanauerite, AgHgSI, and Common Crystal Chemical Features of Natural Mercury Sulphohalides
Authors: Pekov Igor V. , Zubkova Natalia V. , Britvin Sergey N. , Agakhanov Atali A. , Polekhovsky Yury S. , Pushcharovsky Dmitry Y. , Möhn Gerhard , Desor Joy , Blass Günter
Published: August 2023

A new mineral, hanauerite, ideally AgHgSI, was found in the oxidation zone of Ag- and Hg-bearing ores at two old, abandoned mines in Rhineland-Palatinate, Germany. In a holotype specimen originating from the Schöne Aussicht Mine, Dernbach, Westerwald, it is associated with plumbogummite–hinsdalite series of minerals and goethite. In cotype from the Friedrichssegen Mine, Bad Ems, it is associated with perroudite, goethite, and quartz. At both localities, hanauerite occurs as a prismatic crystal up to 0.15 mm long and up to 0.02 mm thick. The mineral is yellow, transparent, with an adamantine lustre. It is brittle, and cleavage was not observed. The calculated density values are 6.671 and 6.575 g cm−3 for holotype and cotype, respectively. The empirical formulae calculated (from electron microprobe data) based on the sum of all atoms = 4 apfu are Ag0.95Hg1.00S1.01(I0.83Br0.19Cl0.03)Σ1.05 for holotype and Ag0.97Hg0.97S1.05(I0.76Br0.25)Σ1.01 for cotype. Hanauerite is orthorhombic, space group Pmma; the unit cell parameters (from single-crystal X-ray diffraction data; holotype/cotype) are: a = 9.932(2)/9.9256(8), b = 4.6219(19)/4.6209(2), c = 9.891(4)/9.9006(4) Å, V = 454.0(3)/454.19(5) Å3, and Z = 4. The crystal structure was studied on single crystals extracted from both holotype and cotype specimens; R1 = 0.0416 (holotype) and =0.0544 (cotype). In hanauerite, Hg2+ cations centre strongly distorted octahedra with two short Hg–S bonds (Hg and S atoms build “crankshaft-type” chains) and four strongly elongated Hg–I bonds. The Hg-centred octahedra are connected via common edges and faces to form corrugated layers; Ag+ cations are located between these layers. Hanauerite is named in honour of the German mineral collector Dr. Alfred Hanauer (1912–1988). The common crystal chemical features of mercury sulphohalide minerals are discussed.
Micro-Structure and Dielectric Properties of Ti3C2Tx MXene after Annealing Treatment under Inert Gases
Authors: Liu Zhiwei , Liu Zhaobo , Li Guanlong , Zhao Yan , Wang Kai , Chen Xiangbao
Published: August 2023

At present, the rapid development of electronic devices such as batteries, sensors, capacitors and so on is creating a huge demand for lightweight materials with a designed structure and function. Ti3C2Tx MXene, a lightweight two-dimensional (2D) nanomaterial with excellent electronic properties, has been favored in this field. In this work, Ti3C2Tx MXene was annealed under an inert gas (N2, Ar and CO2) atmosphere to design the crystal structure and interface of the nanosheets, and then the modified nanosheets with specific changes in dielectric properties were obtained. Among them, the key temperature points (100 °C, 300 °C, 500 °C and 800 °C) in the thermogravimetric (TG) test under an air atmosphere were used as the annealing temperature. When annealing under an air atmosphere, with the increase in temperature, the Ti layer gradually oxidized and evaporated, and the original two-dimensional structure was partly destroyed with some of the C atoms reacting with O2 to form CO2. In the inert gas atmosphere, however, the 2D structure is preserved, except that the surface end groups and layer spacing are changed. In addition, some N element doping was introduced into the nanosheets after N2 atmosphere treatment, which changed the original lattice structure. After the Ar atmosphere treatment, some Ti atoms on the surface were oxidized in situ to form TiO2 grains with different crystal forms, which increased the interfacial area. The C-TiO2 structure of the nanosheets was more complete after treatment with the CO2 atmosphere. All the nanosheets after heat treatment with an inert gas atmosphere retained the characteristic morphology of 2D materials, and different changes in the micro-structure caused changes in dielectric properties, thereby meeting the needs of 2D nanomaterials Ti3C2Tx MXene in different scenarios.
Effectiveness of Photodynamic Therapy as Antiseptic Measure for Oral Cavity and Pharynx: A Systematic Review
Authors: Sologova Diana , Petukhova Marina , Podoplelova Polina , Davletshin Dinislam , Firsova Anna , Grishin Andrey , Grin Mikhail , Suvorov Nikita , Vasil’ev Yuriy , Dydykin Sergey , Rysanova Elena , Shchelkova Victoria , Tarasenko Svetlana , Diachkova Ekaterina
Published: August 2023

Background: The complex traditional treatment of inflammation diseases in oral cavity includes the prescription of antibiotic and antiseptic therapy. This systematic review aims to evaluate the effect of photodynamic therapy as a part of management of inflammatory diseases in oral cavity; Methods: The study is presented in accordance with the preferred reporting points for systematic reviews and meta-analyses (PRISMA). This systematic review was conducted using electronic databases such as Medline PubMed, Scopus and the Cochrane Central Register of Controlled Trials. All the studies in this systematic review, were randomized, the risk of bias 2 (ROB 2) were assessed; Results: Considering the inclusion and exclusion criteria, we included 10 randomized clinical trials, published up to 2023 investigating the application of photodynamic therapy as a part of management of inflammatory diseases in oral cavity. The diode laser was used in the oral cavity in the zone of inflammatory process (gingivitis, mucositis, periimplantitis, marginal periodontitis, abscess, periostitis, osteomyelitis etc.) in nine studies or in the zone before surgical procedures in one study; Conclusion: Based on the results of clinical studies, it can be stated that photodynamic therapy shows good results for operations performed in the oral cavity and pharynx.
An Improved Particle Swarm Optimization Algorithm for the Urban Transit Routing Problem
Authors: Kourepinis Vasileios , Iliopoulou Christina , Tassopoulos Ioannis X. , Aroniadi Chrysanthi , Beligiannis Grigorios N.
Published: August 2023

The Urban Transit Routing Problem (UTRP) is a challenging discrete problem that revolves around designing efficient routes for public transport systems. It falls under the category of NP-hard problems, characterized by its complexity and numerous constraints. Evaluating potential route sets for feasibility is a demanding and time-consuming task, often resulting in the rejection of many solutions. Given its difficulty, metaheuristic methods, such as swarm intelligence algorithms, are considered highly suitable for addressing the UTRP. However, the effectiveness of these methods depends heavily on appropriately adapting them to discrete problems, as well as employing suitable initialization procedures and solution-evaluation methods. In this study, a new variant of the particle swarm optimization algorithm is proposed as an efficient solution approach for the UTRP. We present an improved initialization function and improved modification operators, along with a post-optimization routine to further improve solutions. The algorithm’s performance is then compared to the state of the art using Mandl’s widely recognized benchmark, a standard for evaluating UTRP solutions. By comparing the generated solutions to published results from 10 studies on Mandl’s benchmark network, we demonstrate that the developed algorithm outperforms existing techniques, providing superior outcomes.
Solid State and Semi-Solid Fermentations of Olive and Sunflower Cakes with Yarrowia lipolytica: Impact of Biological and Physical Pretreatments
Authors: Costa Ana Rita , Fernandes Helena , Salgado José Manuel , Belo Isabel
Published: August 2023

Lignocellulosic biomass is a promising feedstock for added value compound production in biotechnological processes such as solid-state fermentation (SSF). Although these solid materials can be directly used as substrates in fermentations in a solid state, a pretreatment is often required, especially if the microorganism selected is unable to produce lignocellulosic enzymes. In the present work, several pretreatment strategies were applied to a 50% (w/w) mixture of olive and sunflower cakes before SSF for lipase production by the oleaginous yeast Yarrowia lipolytica W29. Co-culture strategies with Y. lipolytica and Aspergillus niger did not improve lipase production by the oleaginous yeast. Biological pretreatment with a fungal enzymatic extract led to a significant increase in sugar availability in the substrate mixture after a short incubation period, improving yeast growth. Microwave and ultrasound were the physical pretreatments selected and microwave irradiation proved to be the best method, resulting in 44% and 17% increases in yeast growth and lipase production, respectively, compared to the untreated mixture. An improvement in lipase activity was also observed after ultrasonic treatment in semi-solid fermentations, leading to a 2-fold increase in this enzyme activity compared to the control. The utilization of pretreatments before SSF with Y. lipolytica can increase sugars availability and result in structural changes in the solid substrate, which can improve the bioprocesses’ productivity.
The Effects of Solvent Extraction on the Functional Group Structure of Long-Flame Coal
Authors: Guo Jun , Quan Yanping , Wen Hu , Zheng Xuezhao , Cai Guobin , Jin Yan
Published: August 2023

The functional group structures of coal molecules are one of the most important factors affecting spontaneous combustion. However, it is difficult to determine the exact effects of such structures. Extraction technology is able to modify the functional groups in coal as a means of inhibiting spontaneous combustion reactions. The present work extracted coal from the Caojiatan mine in northern Shaanxi, China, with various solvents. The extraction effectiveness of these solvents was found to decrease in the order of dioctyl sulfosuccinate (AOT) > water > n-hexane > cyclohexane + AOT + ethanol > cyclohexane > ethanol > methanol. With the exception of the AOT, the concentration of functional groups in the extracted coal was decreased compared with that in a control specimen extracted using only water. Ethanol, n-hexane, and methanol provided the optimal extraction efficiencies in terms of capturing coal molecules with aromatic structures, aliphatic structures, and oxygen-containing groups, respectively. The results of this work are expected to assist in future research concerning the extraction of coal molecules with specific functional groups. This work also suggests new approaches to the active prevention and control of spontaneous combustion during the mining, storage, and transportation of coal.
Current and Historical Genetic Variability of Native Brown Trout Populations in a Southern Alpine Ecosystem: Implications for Future Management
Authors: Antognazza Caterina M. , Palandaćić Anja , Delmastro Giovanni B. , Crosa Giuseppe , Zaccara Serena
Published: August 2023

The highly polymorphic taxon European brown trout (genus Salmo) has high phenotypic plasticity, displaying a complex pattern of morphological and life-history variation, contributing to taxonomic confusion. Three main mitochondrial lineages (Adriatic, Mediterranean, and marmoratus) developed during the Pleistocene climatic events in the southern Alpine ecosystem. Here, the natural distribution of native brown trout S. trutta is controversial, complicated by introductions of the Atlantic strain. By investigating museum vouchers, this study aimed to retrace the historical presence of brown trout in the southern Alpine ecosystem before the beginning of mass introductions, which occurred since the middle of the 19th century. By examining the combination of historical and current genetic variability, this study aims to depict the actual impact of introductions of the introduced strain, increasing knowledge and informing conservation strategies and future management plans. The molecular approaches selected were: (i) sequencing of the mitochondrial control region and (ii) genotyping of the nuclear gene LDH-C1*. Vouchers dated the presence of the native Adriatic strain since 1821, while current genetic variability showed the widespread signature of introgression, a consequence of several decades of introductions. Focused plans to preserve local lineages are urgently needed, including short-term solution to avoid complete pauperization of this ecosystem.
Microbial Diversity of Anaerobic-Fermented Coffee and Potential for Inhibiting Ochratoxin-Produced Aspergillus niger
Authors: Lee Bao-Hong , Huang Cheng-Hao , Liu Tsung-Yu , Liou Jung-Shiang , Hou Chih-Yao , Hsu Wei-Hsuan
Published: August 2023

Coffee flavor considerably depends on the fermentation process, with contributing factors including fermentation temperature, oxygen concentration, and microbial diversity. Efficient controlling of the fermentation can improve the quality of coffee beverages. Therefore, several studies on coffee fermentation processes have been conducted in various regions. The objective of this study was to assess the microbial diversity of coffee beans undergoing anaerobic fermentation at various temperatures (4 °C or 37 °C) and fermentation durations (12 h or 36 h) using full-length 16S rRNA sequencing. This analysis aimed to evaluate the inhibitory effects of the fermented metabolites against ochratoxin-producing Aspergillus niger. From our results, Acetobacter was identified as the dominant microbial community at higher fermentation temperatures, whereas Leuconostoc and Gluconobacter were the dominant genera at lower temperatures. However, at lower temperatures, changes in microbial communities were relatively slow. This study expands our knowledge of the microbial diversity involved in the anaerobic fermentation of coffee beans in Taiwan. The findings of this study can be used in future research to cultivate microorganisms linked to the quality and improve the quality of coffee beverages through fermentation.
Adaptive Residual Useful Life Prediction for the Insulated-Gate Bipolar Transistors with Pulse-Width Modulation Based on Multiple Modes and Transfer Learning
Authors: Deng Wujin , Gao Yan , Song Wanqing , Zio Enrico , Li Gaojian , Liu Jin , Kudreyko Aleksey
Published: August 2023

Currently, residual useful life (RUL) prediction models for insulated-gate bipolar transistors (IGBT) do not focus on the multi-modal characteristics caused by the pulse-width modulation (PWM). To fill this gap, the Markovian stochastic process is proposed to model the mode transition process, due to the memoryless properties of the grid operation. For the estimation of the mode transition probabilities, transfer learning is utilized between different control signals. With the continuous mode switching, fractional Weibull motion (fWm) of multiple modes is established to model the stochasticity of the multi-modal IGBT degradation. The drift and diffusion coefficients are adaptively updated in the proposed RUL prediction model. In the case study, two sets of the real thermal-accelerated IGBT aging data are used. Different degradation modes are extracted from the meta degradation data, and then fused to be a complex health indicator (CHI) via a multi-sensor fusion algorithm. The RUL prediction model based on the fWm of multiple modes can reach a maximum relative prediction error of 2.96% and a mean relative prediction error of 1.78%. The proposed RUL prediction model with better accuracy can reduce the losses of the power grid caused by the unexpected IGBT failures.
Blood Transcriptomic Analyses Reveal Functional Pathways Associated with Thermotolerance in Pregnant Ewes Exposed to Environmental Heat Stress
Authors: Luna-Ramirez Rosa I. , Limesand Sean W. , Goyal Ravi , Pendleton Alexander L. , Rincón Gonzalo , Zeng Xi , Luna-Nevárez Guillermo , Reyna-Granados Javier R. , Luna-Nevárez Pablo
Published: August 2023

Environmental heat stress triggers a series of compensatory mechanisms in sheep that are dependent on their genetic regulation of thermotolerance. Our objective was to identify genes and regulatory pathways associated with thermotolerance in ewes exposed to heat stress. We performed next-generation RNA sequencing on blood collected from 16 pregnant ewes, which were grouped as tolerant and non-tolerant to heat stress according to a physiological indicator. Additional samples were collected to measure complete blood count. A total of 358 differentially expressed genes were identified after applying selection criteria. Gene expression analysis detected 46 GO terms and 52 KEGG functional pathways. The top-three signaling pathways were p53, RIG-I-like receptor and FoxO, which suggested gene participation in biological processes such as apoptosis, cell signaling and immune response to external stressors. Network analysis revealed ATM, ISG15, IRF7, MDM4, DHX58 and TGFβR1 as over-expressed genes with high regulatory potential. A co-expression network involving the immune-related genes ISG15, IRF7 and DXH58 was detected in lymphocytes and monocytes, which was consistent with hematological findings. In conclusion, transcriptomic analysis revealed a non-viral immune mechanism involving apoptosis, which is induced by external stressors and appears to play an important role in the molecular regulation of heat stress tolerance in ewes.
The Quiet Epidemic: An Overview of Emerging Qualitative Research Trends on Sedentary Behavior in Aging Populations
Authors: Ramalho André , Petrica João
Published: August 2023

Sedentary behavior poses a significant health risk to older adults. The purpose of this scoping review is to summarize key findings from qualitative research (since 2012), with a focus on explaining prevailing research trends and patterns within the field. This review included 25 studies that met the strict inclusion criteria. Five key research themes have emerged: (1) defining and shaping perspectives of sedentary behavior, (2) understanding the dynamics of daily routines and contexts, (3) raising awareness of older adults’ perceived advantages and disadvantages of sedentary behavior, (4) identifying its determinants and discouraging factors, and (5) exploring interventions to promote active behaviors and reduce sedentary behavior. These themes highlight the multifaceted nature of SB and underscore the importance of tailoring interventions to address individual, social, and environmental issues. A comprehensive understanding of SB is critical to developing effective strategies to promote active lifestyles and reduce SB in older adults. Further qualitative research is needed to deepen our understanding and develop targeted interventions and strategies.
Optimizing Clinical Decision Making with Decision Curve Analysis: Insights for Clinical Investigators
Authors: Piovani Daniele , Sokou Rozeta , Tsantes Andreas G. , Vitello Alfonso Stefano , Bonovas Stefanos
Published: August 2023

A large number of prediction models are published with the objective of allowing personalized decision making for diagnostic or prognostic purposes. Conventional statistical measures of discrimination, calibration, or other measures of model performance are not well-suited for directly and clearly assessing the clinical value of scores or biomarkers. Decision curve analysis is an increasingly popular technique used to assess the clinical utility of a prognostic or diagnostic score/rule, or even of a biomarker. Clinical utility is expressed as the net benefit, which represents the net balance of patients’ benefits and harms and considers, implicitly, the consequences of clinical actions taken in response to a certain prediction score, rule, or biomarker. The net benefit is plotted against a range of possible exchange rates, representing the spectrum of possible patients’ and clinicians’ preferences. Decision curve analysis is a powerful tool for judging whether newly published or existing scores may truly benefit patients, and represents a significant advancement in improving transparent clinical decision making. This paper is meant to be an introduction to decision curve analysis and its interpretation for clinical investigators. Given the extensive advantages, we advocate applying decision curve analysis to all models intended for use in clinical practice.
Facilitators and Barriers to Oral Healthcare for Women and Children with Low Socioeconomic Status in the United States: A Narrative Review
Authors: Lieneck Cristian , Connelly Erin , Ireland Daryah , Jefferson Alexandra , Jones Jesikuh , Breidel Nicole
Published: August 2023

This rapid review examined facilitators and barriers affecting oral healthcare access and utilization among women and children with a low socioeconomic status (SES) in the United States from 2019 to the present. A comprehensive search was conducted across multiple electronic databases, yielding a total of 30 relevant studies for inclusion. The findings highlight various facilitators that positively impact oral healthcare outcomes, including targeted educational programs, access to non-dental care healthcare services, community-based initiatives, and increased access to affordable oral health services. Conversely, barriers such as financial constraints, lack of access to food program social assistance, access to care difficulties, and limited oral health literacy were identified as major challenges faced by this population. Understanding these facilitators and barriers during the COVID-19 global pandemic can inform the development of tailored interventions and policies aimed at improving oral healthcare outcomes for women and children with a low SES in the United States.
Effects of Muscular Strength Training on Oral Health and Quality of Life: Using Korean Panel Survey Data, a Cross-Sectional Study
Authors: Jang Kyeung-Ae , Kim Yu-Rin
Published: August 2023

Objectives: The purpose of this study is to confirm the importance of muscular strength exercise by confirming the relationship between strength exercise, oral health, and quality of life. Methods: Using the 2019 and 2021 of the Korean National Health and Nutrition Examination Survey (KNHANES), 6535 people were selected as subjects. Complex sampling analysis was applied to all analyses; 2267 people were in the muscular strength training group (MSG), and 5841 people were in the non-muscular strength training group (NMSG). A multi-sample linear regression analysis was conducted to confirm the effect of muscular strength training on oral health and quality of life. Results: As a result of confirming the effect of muscular strength training on oral health status, problems with chewing decreased by 0.105, and problems with speaking decreased by 0.028 with MSG compared to NMSG. In addition, compared to NMSG, it was confirmed that MSG reduced chewing discomfort by 0.047, while self-perceived oral health improved by 0.0123. Finally, as a result of confirming the effect of muscular strength training on oral health and quality of life in Korean adults, there was a significant effect on quality of life despite adjusting for sociodemographic characteristics and oral-health-related factors (p < 0.05). Conclusions: In this study, the relationship between muscular strength training and quality of life was confirmed. Therefore, efforts should be made to make oral health management and muscular strength training a part of life in relation to quality of life.
The Effects of Plant-Derived Phytochemical Compounds and Phytochemical-Rich Diets on Females with Polycystic Ovarian Syndrome: A Scoping Review of Clinical Trials
Authors: Chavez Guadalupe Nayeli , Jaworsky Kataryna , Basu Arpita
Published: August 2023

Polycystic ovarian syndrome (PCOS) is an endocrine condition that impacts nutritional status, metabolic, and hormonal function in females of reproductive age. This condition is associated with increased androgen production (hyperandrogenism) and decreased insulin sensitivity, which often leads to insulin resistance and hyperinsulinemia. This increase in androgen production and insulin resistance is strongly associated with a high incidence of obesity, type-2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), and certain types of gonad-related cancers among females who suffer from this condition. As research continues to grow, it has been demonstrated that PCOS is a complex condition, and some of its characteristics vary among the females that have this disorder. However, it has been suggested that oxidative stress and low-grade chronic inflammation could play an important role in the development of PCOS. Current evidence suggest that phytochemicals could potentially help with weight-loss by reducing oxidative stress and low-grade inflammation, as well as aid in metabolic and hormonal regulation due to their antioxidant properties. Some of the bioactive compounds found in plants that have shown positive effects in the attenuation of PCOS include flavonoids, polyphenols, phytoestrogen, and polyunsaturated fatty acids (PUFAs). Thus, a review of the current literature published on PCOS and phytochemicals was conducted in PubMed, Google Scholar, and the Academy of Nutrition and Dietetics databases for articles published between 2013 and 2023 with a study duration of 1 to 3 months and adequate sample sizes. The main purpose of this review of literature was to investigate the metabolic effects of phytochemical compounds and phytochemical-rich diets on females with PCOS by comparing the results of several randomized clinical trials.
Oxidative Stress and Lung Fibrosis: Towards an Adverse Outcome Pathway
Authors: Makena Patrudu , Kikalova Tatiana , Prasad Gaddamanugu L. , Baxter Sarah A.
Published: August 2023

Lung fibrosis is a progressive fatal disease in which deregulated wound healing of lung epithelial cells drives progressive fibrotic changes. Persistent lung injury due to oxidative stress and chronic inflammation are central features of lung fibrosis. Chronic cigarette smoking causes oxidative stress and is a major risk factor for lung fibrosis. The objective of this manuscript is to develop an adverse outcome pathway (AOP) that serves as a framework for investigation of the mechanisms of lung fibrosis due to lung injury caused by inhaled toxicants, including cigarette smoke. Based on the weight of evidence, oxidative stress is proposed as a molecular initiating event (MIE) which leads to increased secretion of proinflammatory and profibrotic mediators (key event 1 (KE1)). At the cellular level, these proinflammatory signals induce the recruitment of inflammatory cells (KE2), which in turn, increase fibroblast proliferation and myofibroblast differentiation (KE3). At the tissue level, an increase in extracellular matrix deposition (KE4) subsequently culminates in lung fibrosis, the adverse outcome. We have also defined a new KE relationship between the MIE and KE3. This AOP provides a mechanistic platform to understand and evaluate how persistent oxidative stress from lung injury may develop into lung fibrosis.
Renal Perfusion, Oxygenation and Metabolism: The Role of Imaging
Authors: Päivärinta Johanna , Anastasiou Ioanna A. , Koivuviita Niina , Sharma Kanishka , Nuutila Pirjo , Ferrannini Ele , Solini Anna , Rebelos Eleni
Published: August 2023

Thanks to technical advances in the field of medical imaging, it is now possible to study key features of renal anatomy and physiology, but so far poorly explored due to the inherent difficulties in studying both the metabolism and vasculature of the human kidney. In this narrative review, we provide an overview of recent research findings on renal perfusion, oxygenation, and substrate uptake. Most studies evaluating renal perfusion with positron emission tomography (PET) have been performed in healthy controls, and specific target populations like obese individuals or patients with renovascular disease and chronic kidney disease (CKD) have rarely been assessed. Functional magnetic resonance (fMRI) has also been used to study renal perfusion in CKD patients, and recent studies have addressed the kidney hemodynamic effects of therapeutic agents such as glucagon-like receptor agonists (GLP-1RA) and sodium-glucose co-transporter 2 inhibitors (SGLT2-i) in an attempt to characterise the mechanisms leading to their nephroprotective effects. The few available studies on renal substrate uptake are discussed. In the near future, these imaging modalities will hopefully become widely available with researchers more acquainted with them, gaining insights into the complex renal pathophysiology in acute and chronic diseases.
Global Epidemiology and Burden of Elderly-Onset Inflammatory Bowel Disease: A Decade in Review
Authors: Danpanichkul Pojsakorn , Suparan Kanokphong , Arayakarnkul Suchapa , Jaroenlapnopparat Aunchalee , Polpichai Natchaya , Fangsaard Panisara , Kongarin Siwanart , Srisurapanont Karan , Sukphutanan Banthoon , Wanchaitanawong Wasuwit , Kanjanakot Yatawee , Pupaibool Jakrapun , Duangsonk Kwanjit , Kochhar Gursimran Singh , Wijarnpreecha Karn
Published: August 2023

Inflammatory bowel disease (IBD), once thought to impact younger individuals, now manifests in approximately 10% of patients over 65, characterized by a heightened vulnerability to complications and greater diagnostic intricacies than conventional cases. However, comprehensive global epidemiological data regarding elderly-onset IBD are currently insufficient. Our study addresses this critical gap by analyzing trends in elderly-onset IBD over a decade, encompassing the estimation of annual frequencies and age-standardized rates of elderly-onset IBD burden for both genders, stratifying the data by geographical and sociodemographic factors. Our research highlights a notable increase in the proportion of elderly-onset IBD, constituting around 13% of all IBD cases. We observed a rising incidence in males, contrasted by a decreasing trend in females. The highest surge in incidence rates was seen in the Western Pacific region in both genders, but the highest burden was observed in America. Countries with high sociodemographic index (SDI) carried the greatest burden of elderly-onset IBD, while countries with low SDI had the least. The mortality and disability-adjusted life years (DALYs) rates trend downward in most regions. This study underscores an increasing incidence and proportion of IBD, particularly in elderly-onset IBD, particularly in males. While mortality and DALYs are decreasing in most regions, the overall burden remains highest in America and high-SDI countries. Effective public health interventions and comprehensive studies are required to tackle this mounting burden.
Vertical Jump Kinetic Parameters on Sand and Rigid Surfaces in Young Female Volleyball Players with a Combined Background in Indoor and Beach Volleyball
Authors: Giatsis George , Panoutsakopoulos Vassilios , Frese Christina , Kollias Iraklis A.
Published: August 2023

Little is known about the differences in vertical jump biomechanics executed on rigid (RJS) and sand (SJS) surfaces in female indoor and beach volleyball players. Eleven young female beach volleyball players with a combined indoor and beach volleyball sport background performed squat jumps, countermovement jumps with and without an arm swing, and drop jumps from 40 cm on a RJS (force plate) and SJS (sand pit attached to the force plate). The results of the 2 (surface) × 4 (vertical jump test) repeated-measure ANOVA revealed a significant (p < 0.05) main effect of the surface and the vertical jump test on the jump height and time to achieve peak vertical body center of mass velocity. A significant (p < 0.05) main effect of the test, but not of the surface (p > 0.05), was observed for the other examined biomechanical parameters. The only significant (p < 0.05) jump height gain difference between RJS and SJS was observed for the utilization of the stretch-shortening cycle, which was higher in SJS (15.4%) compared to RJS (7.5%). In conclusion, as the testing was conducted during the beach volleyball competitive season, the examined female players showed adaptations relating the effective utilization of the pre-stretch and enhanced stability during the execution of the vertical jump tests on a SJS compared to RJS.
A Unified Numerical Method for Broaching and Loss of Stability in Astern Seas
Authors: Lu Jiang , Gu Min , Boulougouris Evangelos
Published: August 2023

The interim guidelines of second-generation intact stability criteria and their explanatory note were issued by the IMO in 2022. However, due to their complexity, the direct stability assessments of broaching and loss of stability still need to be made easier for users. Therefore, the mathematical models for broaching and loss of stability in astern seas are studied in this paper. Firstly, a time-domain 6 DOF numerical model is adopted, combining seakeeping and maneuvering mathematical models. Secondly, the hydrodynamic forces, heave, and pitch motions are obtained by an enhanced strip method with the upright hull at different speeds in the frequency domain. Then, their time-domain values are transferred from their frequency-domain values with the speed variation considered. Thirdly, the time-domain varied wet hull in waves is captured by the 6 DOF ship motion. Then, the Froude–Krylov and the hydrostatic forces in the surging, swaying, rolling, and yawing directions are simulated considering the wave pressure around the wet hull. Fourthly, the exposure of the twin rudders and the wave-particle velocity are considered for predicting broaching. Finally, the calculated results are compared with the published results. The results show that the time-domain 6 DOF coupled numerical model can be unified for predicting broaching and loss of stability in the astern seas.
Unraveling the Ecological Tapestry: A Comprehensive Assessment of Changtang Nature Reserve’s Ecological and Environmental Using RSEI and GEE
Authors: Peng Xuefeng , Zhang Shiqi , Peng Peihao , Chen Ailin , Li Yang , Wang Juan , Bai Maoyang
Published: August 2023

The Changtang Nature Reserve, located in the hinterland of the Qinghai-Tibet Plateau, plays a crucial role in researching ecological and environmental assessment on the plateau. However, the severe natural conditions in the Changtang Plateau have resulted in the absence of meteorological observation stations within the reserve, thereby leading to a lack of fundamental ecological and environmental research data. Remote sensing technology presents an opportunity for ecological monitoring in the Changtang Nature Reserve. In this study, remote sensing ecological indices (RSEI) were utilized to evaluate the ecological environment of the reserve from 2000 to 2020. The MODIS data reconstructed using the Savitzky-Golay filter on the Google Earth Engine (GEE) platform were employed. Principal component analysis was then conducted to construct the RSEI. The results reveal that the overall ecological environment quality in the Changtang Nature Reserve between 2000 and 2020 was relatively poor. Over the past two decades, the mean RSEI of the reserve exhibited a fluctuating trend of decrease and increase, indicating a deteriorating and subsequently improving ecological environment quality. Specifically, during the period of 2000–2010, the RSEI mean decreased from 0.3197 to 0.2269, suggesting degradation of the ecological environment, and the proportion of areas classified as fair and poor increased by 51.99%, while the proportion of areas classified as good and excellent decreased by 32.69%. However, from 2010 to 2020, it increased from 0.2269 to 0.3180, indicating an improvement in the ecological environment, and the proportion of areas classified as good and excellent increased by 6.11%, while the proportion of areas classified as fair and poor decreased by 2.91%. Spatially, the core zone demonstrated higher ecological environment quality compared to the experimental and buffer zones. The findings of this study provide comprehensive and accurate information about the ecological environment, which supports management, decision-making, and emergency response efforts in the Changtang Nature Reserve. Moreover, it offers a scientific basis for conservation and sustainable development strategies in the reserve. The quantitative assessment of the ecological environment dynamics contributes to the understanding of the reserve’s ecological dynamics and facilitates informed decision-making for effective conservation and management practices.
Anisotropy in Additively Manufactured Concrete Specimens under Compressive Loading—Quantification of the Effects of Layer Height and Fiber Reinforcement
Authors: Surehali Sahil , Tripathi Avinaya , Neithalath Narayanan
Published: August 2023

This paper analyzes the effect of print layer heights and loading direction on the compressive response of plain and fiber-reinforced (steel or basalt fiber) 3D printed concrete. Slabs with three different layer heights (6, 13, and 20 mm) are printed, and extracted cubes are subjected to compression (i) along the direction of printing, (ii) along the direction of layer build-up, and (iii) perpendicular to the above two directions. Digital image correlation (DIC) is used as a non-contact means to acquire the strain profiles. While the 3D printed specimens show lower strengths, as compared to cast specimens, when tested in all three directions, this effect can be reduced through the use of fiber reinforcement. Peak stress and peak strain-based anisotropy coefficients, which are linearly related, are used to characterize and quantify the directional dependence of peak stress and strain. Interface-parallel cracking is found to be the major failure mechanism, and anisotropy coefficients increase with an increase in layer height, which is attributable to the increasing significance of interfacial defects. Thus, orienting the weaker interfaces appropriately, through changes in printing direction, or strengthening them through material modifications (such as fiber reinforcement) or process changes (lower layer height, enables attainment of near-isotropy in 3D printed concrete elements.
Controlled Invariant Sets of Discrete-Time Linear Systems with Bounded Disturbances
Authors: Wang Chengdan , Yang Hongli , Ivanov Ivan Ganchev
Published: August 2023

This paper proposes two novel methods for computing the robustly controlled invariant set of linear discrete-time systems with additive bounded disturbances. In the proposed methods, the robustly controlled invariant set of discrete-time systems is obtained by solving the linear matrix inequality given by logarithmic norm and difference inequality. Illustrative examples are presented to demonstrate the obtained methods.
Semi-Analytical Methods in the Problem of Deformation of a Fluid Strip
Authors: Karabut Evgenii , Zhuravleva Elena
Published: August 2023

A problem from a class of unsteady plane potential flows with a free boundary is considered. The entire boundary occupied by the liquid is free, and a zero pressure is maintained. There are neither external nor capillary forces. The motion is driven by inertia. The parameters prescribed at the initial time are the velocity field and the domain occupied by the fluid. The task is to determine these parameters at subsequent time instants. The solution is sought in the form of power series, which are then summed up with the use of the Pade approximation.
Dental Appliances for the Treatment of Obstructive Sleep Apnea in Children: A Systematic Review and Meta-Analysis
Authors: Marciuc Daniel , Morarasu Stefan , Morarasu Bianca Codrina , Marciuc Emilia Adriana , Dobrovat Bogdan Ionut , Pintiliciuc-Serban Veronica , Popescu Roxana Mihaela , Bida Florinel Cosmin , Munteanu Valentin , Haba Danisia
Published: August 2023

Background and objectives: Obstructive sleep apnea (OSA) in children is a debilitating disease, difficult to treat. Dental appliances have been proposed as a valid therapy for improving functional outcomes with good compliance rates. Herein, we aimed to perform a meta-analysis comparing clinical outcomes between OSA children treated with dental appliances versus controls. Materials Methods: The study was registered with PROSPERO. A systematic search was performed for all comparative studies examining outcomes in pediatric patients who underwent treatment of OSA with oral appliances versus controls. Data was extracted and analyzed using a random effects model via Rev Man 5.3. Results: Six studies including 180 patients were analyzed split into two groups: patients treated with dental appliances (n = 123) and the controls (n = 119). Therapy with dental appliances was shown to significantly improve the apnea–hypopnea index (p = 0.009) and enlarge the superior posterior airway space (p = 0.02). Maxilla-to-mandible measurements were not significantly different between the two groups, nor was the mean SO2 (p = 0.80). Conclusions: This is the most updated meta-analysis assessing the role of dental appliances for OSA in children; it shows that such devices can improve functional outcomes by decreasing the apnea–hypopnea index.
Mesenchymal Stem Cells in Soft Tissue Regenerative Medicine: A Comprehensive Review
Authors: Rehman Ayesha , Nigam Aditya , Laino Luigi , Russo Diana , Todisco Celestino , Esposito Giuseppe , Svolacchia Fabiano , Giuzio Federica , Desiderio Vincenzo , Ferraro Giuseppe
Published: August 2023

Soft tissue regeneration holds significant promise for addressing various clinical challenges, ranging from craniofacial and oral tissue defects to blood vessels, muscle, and fibrous tissue regeneration. Mesenchymal stem cells (MSCs) have emerged as a promising tool in regenerative medicine due to their unique characteristics and potential to differentiate into multiple cell lineages. This comprehensive review explores the role of MSCs in different aspects of soft tissue regeneration, including their application in craniofacial and oral soft tissue regeneration, nerve regeneration, blood vessel regeneration, muscle regeneration, and fibrous tissue regeneration. By examining the latest research findings and clinical advancements, this article aims to provide insights into the current state of MSC-based therapies in soft tissue regenerative medicine.
Metabolic Covariance Connectivity of Posterior Cingulate Cortex Associated with Depression Symptomatology Level in Healthy Young Adults
Authors: Wang Zhixin , Baeken Chris , Wu Guo-Rong
Published: August 2023

Early detection in the development of a Major Depressive Disorder (MDD) could guide earlier clinical interventions. Although MDD can begin at a younger age, most people have their first episode in young adulthood. The underlying pathophysiological mechanisms relating to such an increased risk are not clear. The posterior cingulate cortex (PCC), exhibiting high levels of brain connectivity and metabolic activity, plays a pivotal role in the pathological mechanism underlying MDD. In the current study, we used the (F-18) fluorodeoxyglucose (FDG) positron emission tomography (PET) to measure metabolic covariance connectivity of the PCC and investigated its association with depression symptomatology evaluated by the Centre for Epidemiological Studies Depression Inventory—Revised (CESD-R) among 27 healthy individuals aged between 18 and 23 years. A significant negative correlation has been observed between CESD-R scale scores and the PCC metabolic connectivity with the anterior cingulate, medial prefrontal cortex, inferior and middle frontal gyrus, as well as the insula. Overall, our findings suggest that the neural correlates of depressive symptomatology in healthy young adults without a formal diagnosis involve the metabolic connectivity of the PCC. Our findings may have potential implications for early identification and intervention in people at risk of developing depression.
Experimental Research of High-Quality Drilling Based on Ultrasonic Vibration-Assisted Machining
Authors: Deng Shuang , Guo Yu , Lu Songsong
Published: August 2023

Micro-hole is widely used in various fields, and common machining methods of micro-hole in factories are drilling and electrical discharge machining (EDM), but because of low machining efficiency, these methods cannot meet requirements. Therefore, it is urgent to investigate a high efficient micro-hole machining technology to meet the demands of micro-hole machining in factory. Over past few decades, ultrasonic machining technology has developed rapidly and achieved good results in solving many critical machining problems in field of difficult-to-cut materials. Therefore, this paper builds an ultrasonic vibration-assisted drilling (UAD) experiments platform to combine micro-fine small hole drilling with ultrasonic machining technology for micro-hole multi-factor experimental research. Results show that UAD machining of micro-hole below diameter 0.5 mm is comparable to conventional drilling machining because of its high-frequency pulse intermittent cutting process, stable change in machining diameter, good stability of parameters such as shape tolerance roundness and cylindricity, small cutting force during cutting, small tool wear, and small surface roughness of inner wall of micro-hole. Compared with EDM, UAD has high efficiency and good stability of parameters such as diameter and roundness of shape tolerance. Comprehensive analysis of UAD can be used as an alternative technology solution for machining small holes in non-special requirements of metal materials in factory and has technical feasibility of stable batch production.
Special Issue: Gram-Positive Bacterial Toxins
Authors: Sharma Shashi , Pellett Sabine , Morse Stephen A.
Published: August 2023

The Gram stain classifies most bacteria into one of two groups, Gram-negative or Gram-positive, based on the composition of their cell walls [...]