bluuebunny/crossref_metadata_2025 huggingface dataset:
THE RUSSIAN ANESTHESIOLOGY AND CRITICAL CARE IN 2019 – WHAT WE HAVE ACHIEVED AND WHERE WE GO
Authors: Polushin Yu. S.
Published: May 2019

Looking back at the 60-year period of anesthesiology and critical care development in this country, the author paid special attention to some considerations that largely reflect the ideology and psychology of specialists working in this field, who, from his point of view, interfered with further development of this specialty as an independent medical field in Russia. Special emphasis was put on some problematic issues of interdisciplinary interaction, training, and organization of care. It was noted that the experience of predecessors was to be taken into account since the essence of many current problems was in many ways the same as it had been before. The author suggested that moving forward was possible only if the efforts of the entire professional community were consolidated.
PERI-OPERATIVE REHABILITATION: ERAS OR PICS PREVENTION?
Authors: Gubaydullin R. R. , Gusakova E. V. , Cheremisov V. V. , Rymarchuk R. A. , Kulakov V. V. , Cherepanova O. N.
Published: May 2019

Rehabilitation technologies and provision of conditions for their implementation in surgery units, as well as in resuscitation and intensive care wards make an integral part of the modern medical practice. Currently, the efficacy of these approaches has been proven and formalized to a certain extent in the form of enhanced recovery after surgery in the intensive care units. Despite the different context and categories of patients on rehabilitation, these approaches have much in common both from a scientific and clinical point of view.
Core survival guide (ARCHIVED)
Authors:   Association of Anaesthetists, Shewry Liz
Published: May 2019

Anaesthetics has traditionally been a specialty which junior doctors entered after two to three years of postgraduate training. However, the ongoing changes in postgraduate medical training mean the majority of junior doctors are now entering anaesthetics following the Foundation Programme. This means appropriate support and guidance are even more important to ensure the welfare and success of future anaesthetic consultants. The Core Survival Guide is an introduction to the specialty, aimed at early training years. It starts from day one and leads to obtaining a ST3 post.
Guidance includes: Preparing for your first day as an anaesthetist; Health and safety; Portfolio and logbook; Training in anaesthesia; The Annual Review of Competence Progression (ARCP); The Primary FRCA examination; Getting an ST3 post in anaesthetics.
Source separation and apportionment of surface water pollution in the Luanhe River Basin based on non-negative matrix factorization
Authors: Leng Peifang , Zhang Qiuying , Li Fadong , Zhang Yizhang , Gu Congke
Published: May 2019

Understanding the spatial and temporal variations and source apportionment of water pollution is important for efficient water environment management. The non-negative matrix factorization (NMF) method, which is naturally well suited for non-negative data of high dimension, was used to identify the latent factors and apportion the contributions from identified pollution sources to each water quality parameter. We obtained a data matrix with 11 water quality variables collected from 2013 to 2016 in the Luanhe River Basin in northern China. The results highlight the substantial contribution of industrial and livestock wastewater. All land-use types have a slightly weaker impact on surface water pollution during the dry season than during the rainy season. The aim of this study is to illustrate the practicability of multivariate statistical analysis, especially the application of NMF, which has major potential for source separation and the apportionment of water pollution.
Tiapride for the Treatment of REM Sleep Behaviour Disorder in Dementia with Lewy Bodies: A Case Series
Authors: Adler Georg , Mautes Angelika E.
Published: May 2019

Objective:

REM sleep Behaviour Disorder (RBD) in Dementia with Lewy bodies (DLB) may be attributed to a decrease in dopaminergic neurotransmission. Thus, we studied the therapeutic efficacy of the pre and postsynaptic D2 and D3 receptor antagonist tiapride, which at a low dosage preferentially blocks presynaptic dopamine receptors and consequently leads to feedback activation of dopamine synthesis and to increased extracellular levels of dopamine.

Methods:

Six consecutive patients presenting at our memory clinic with RBD in DLB, in whom melatonin had been ineffective and clonazepam was found inappropriate for clinical reasons, were treated with triapride at dosages between 50 and 150 mg for twelve weeks.

Results:

Tiapride was well tolerated by all patients. Five of the six patients, reported was a decrease of the self-perceived frequency of bad dreams and the intensity and severity of motor and vocal enactments during sleep. In four of these six patients, this was also the case in the view of the patients’ bed partners.

Conclusion:

Tiapride may by an effective and well-tolerated treatment for RBD in patients with DLB.
Methicillin Resistant Staphylococcus aureus and Extended Spectrum Beta-lactamase Producing Enterobacteriaceae: A Therapeutic Challenge in the 21st Century
Authors: Donkor Eric S. , Codjoe Francis S.
Published: May 2019

Antimicrobial resistance is one of the greatest global threats to human health in recent times and it limits the achievement of several of the Sustainable Development Goals. Methicillin-ResistantStaphylococcus aureus(MRSA) and Extended-Spectrum Beta-Lactamase (ESBL) producingEnterobacteriaceaeare among the most important multidrug resistant bacterial pathogens. MRSA and ESBL-producingEnterobacteriaceaehave evolved significantly over the last few decades with important clinical and epidemiological implications. Given the slow progress of development of new antibiotics in recent times, it is likely that these multidrug resistant pathogens will have a greater impact on public health in the 21stCentury, unless other effective control measures are instituted. Effective infection control strategies coupled with antibiotic stewardship programs are required to limit the spread and burden of MRSA and ESBL-producingEnterobacteriacae.
Family Medicine Trainees’ Knowledge about Topical Corticosteroids in Jeddah, Saudi Arabia
Authors: Kokandi Amal A
Published: May 2019

Background:

Topical corticosteroids (TCS) are used to treat a variety of dermatological conditions. The fear of side effects sometimes affects the adherence to treatment. The aim of this study was to assess the knowledge and the attitude of family medicine residents under training for the use of TCS.

Methods:

Family medicine trainees attending an educational session were surveyedvialive electronic questionnaires.

Results:

A total of 89 (out of 100 who attended the event) people responded to the questionnaire. Undergraduate teaching was the main source of information about TCS. Most of the respondents advised the use of TCS sparingly or using finger-tip unit amount. More than half of them thought TCS can be absorbed and it should not be used to some body areas such as eyelids. Majority of the respondents did not think that TCS use can lead to infections, weight gain or obesity, damage the skin if used for a few weeks, negatively affect health or lead to asthma. More than 40% thought that it is better to stop TCS treatment as soon as possible in atopic dermatitis patients.

Conclusion:

Family medicine trainees have some fears and misconceptions regarding TCS use. There is a need to increase the knowledge about TCS in undergraduate and postgraduate teaching.
Recent Advances and Novel Approaches for Nose to Brain Drug Delivery for Treatment of Migraine
Authors: Sachan Nidhi , Bahadur Shiv , Sharma Pramod K.
Published: May 2019

Background:

Nasal drug delivery has been used since ancient times for therapeutic and recreational purposes. For the last decades, nasal drug delivery has been extended for drug delivery to the brain. Therefore, it is important to understand the several physiological and physicochemical factors of the nose for brain drug delivery.

Objective:

A major highlight of the present review article is the several aspects of the nose to brain delivery for migraine treatment. This review will help to understand different factors which are needed to be considered for intra-nasal formulations to achieve the desired therapeutic effects.

Method:

There are different drug delivery routes available for migraine treatment. Nasal route of administration may be optimal for migraine treatment which has better drug concentration in the brain. These approaches may be associated with limiting the adverse effects of drug therapeutics.

Results:

A list of total FDA approved approaches has been provided. Novel approaches used for drug targeting to get maximum drug concentration in the brain have been highlighted. Several novel drug delivery approaches such as nanoparticle, nanoemulsion, microspheres, etc. have been reported and better therapeutic effects have been observed. Among the novel approaches, some of them are currently under either Phase II or Phase III development but may prove to offer better clinical effects. These approaches would become the alternate choice for migraine treatment with patients experiencing symptoms consistent with gastrointestinal dysfunction associated with migraine.

Conclusion:

Intra-nasal administration of drugs for migraine treatment may offer an interesting alternative for achieving therapeutic effects of drugs which are comparable to the parenteral route. Nasal drug delivery can be an alternative route of drug administration for migraine treatment to achieve better bioavailability.
SUBOPTIMAL MANAGEMENT MODEL IN THE TECHNOLOGY OF RADIO-ELECTRONIC EQUIPMENT
Authors: Vershinina L. P. , Vershinin M. I.
Published: May 2019

In conditions of small-scale production of radio-electronic equipment cost reduction can be achieved through the optimization of technological processes (TP). Discusses problems in the formulation of optimization problems. It is shown that the dynamism, the limited, incomplete and ambiguous information available make traditional methods of optimization management of TP unsuitable for practical use. Topical question of the elaboration of models of governance, which reflect the dynamics of the TP, adapt to changing conditions, are operating under a limited amount of experimental data. The article shows that the problems in the setting and solving optimization problems of TP can be solved using apparatus of the theory of fuzzy sets, the solution is suboptimal. Suboptimal management models designed for model TP small-scale production. Models implement the proposed approach and is suitable for practical use.
QUALITY ASSURANCE OF ADDITIVE MANUFACTURING THROUGH LAYER-BY-LAYER CONTROL SYSTEM
Authors: Chabanenko A. V. , Smirnova V. O. , Smirnov A. O. , Rozhkov N. N.
Published: May 2019

Today additive technologies are one of the most dynamically developing types of «digital» production. They allow to achieve acceleration of the solution of problems of preparation and adjustment of production and are already actively applied and to production of finished goods. Additive technologies are a part of industrial robots (IR). On their basis there is a possibility of the organization of complexes with a possibility of fast adjustment and readjustment which, in the majority, are intended for building in the flexible automated lines of additive production. The greatest efficiency of automation of layer-by-layer synthesis at the expense of IR can be reached due to the comprehensive approach to a question of creation and introduction of quality assurance systems considering features of structure and mechanisms of work of the additive installation. To control the quality of layer-by-layer synthesis by means of the control system of the additive installation, it is necessary to take into account the structural features of the 3D-Lapper. An important role in the work of additive plants is played by the properties of the polymers used in bulk printing, which affect the quality of the final product.
THERMAL CONDUCTIVITY OF COMPOSITIONS BASED ON A SILOXANE BINDER WITH A HIGH FILLER CONTENT OF ALUMINUM HYDROXIDE POWDER
Authors: Sulaberidze V. Sh. , Mushenko V. D. , Mikheev V. A.
Published: May 2019

The use of aluminum hydroxide as a filler in composite materials makes them non-flammable. When the thermal conductivity of such compositions is above 1 W/(m-K), they can be used as heat-conducting insulating and non-flammable coatings in power electronics. Thermal conductivity of compositions based on dimethylsiloxane with a filler made from aluminum hydroxide powders of various dissipation is studied in the temperature range from 25 °C to 200 °C, depending on the volume content of the filler. With a volumetric content of filler up to 60%, no significant differences in the values of the thermal conductivity of samples with powders of the investigated fractional groups were detected. With volumetric content of the filler more than 40%, the thermal conductivity of the composition at room temperature exceeded 1 W/(m-K). It is shown that the Burger formula modified by the authors turned out to be sufficiently universal for the calculated estimates of the thermal conductivity of materials with different fillers in a wide range of their volume contents.
DESIGN AND MANUFACTURE OF ELECTRONIC TECHNICAL MEANS OF AUTOMATION FOR ELECTRIC DRIVE IN CONDITIONS OF DIGITAL DEVELOPMENT
Authors: Korshunov G. I. , Semenova E. G. , Petrushevskaya A. A. , Smirnova M. S.
Published: May 2019

The main stages of the life cycle of electronic technical means of automation of an electric drive from the point of view of completeness of introduction of digital technologies are considered. A brief analysis of models, methods and tools is performed to achieve the effectiveness of the end-to-end digital process of development and production of programmable controllers for the electric drive. The approaches for variants formation of the basic structure of the controller, the creation of a digital model (prototype) of the controller, the provision of design taking into account the technology, the improvement of the installation of printed circuit boards on the automatic line in accordance with the concept of Industry 4.0, functional control, diagnostics and testing are proposed. The step by step continuity implement of the primary digital model is suggested. The presented material is confirmed by examples of creation of programmable controllers for complete devices of AC drives used in walking excavators, crawler excavators and traction electric drives for BelAZ dump trucks.
PREPARATION OF ENTANGLED PAIRS OF PHOTONS IN BARIUM BETA BORATE CRYSTAL
Authors: Marchenko O. M. , Litvinova N. N. , Prilipko V. K.
Published: May 2019

For the last two decades, the focus of scientific research in the field of information transmission and processing has been in such sections of quantum optics as quantum computing and quantum cryptography. These areas of optics rely on the discovery of a special type of radiation - beams with pairs of bound or entangled photons. The experimental work in Russia, devoted to the entangled photons is undeservedly little. Therefore, the proposed work is important from a methodical point of view. Moreover, the experiment is performed on domestic equipment, much cheaper than most foreign analogues. The described system can be used as a prototype for setting up educational demonstration and laboratory works. Therefore, the proposed work will be of interest to researchers and universities involved in quantum optics. As a result of the work done, the attempt to create a source of entangled photons based on a barium beta-borate crystal can be considered successful. It should be added that in a second type of crystal pairs of entangled photons arise not only with respect to directions (and frequencies), but also with respect to two orthogonal polarizations. A similar source makes it possible to set up experiments similar to the Einstein-Podolsky-Rosen thought experience in Bohm’s interpretation. Therefore, it is also suitable for testing the Bell inequality. The article considers the practical importance of the phenomenon of generation of entangled photons for the purposes of quantum cryptography, the phenomenon of spontaneous parametric scattering and the creation of a source of entangled pairs of photons based on it, the experimental system and the results of the experiment on generation of correlated photon pairs, tangled with respect to directions and frequencies, the result of the experiment on observing the correlation in the detection times of pairs of entangled photons.
THREE-DIMENSIONAL FIGURES ARRAY BUILDING AUTOMATION IN ORIGINAL DATASET USING WINDOWS PRESENTATION FOUNDATION PLATFORM
Authors: Lachikhina A. B. , Soldatov K. N.
Published: May 2019

When storing geometric shapes in the database as a set of numerical values of parameters, the task of constructing their visual representations arises. Visualization of objects on the set parameters is the purpose of this study. As a tool, we propose to use the Windows Presentation Foundation (WPF) platform. The paper considers the objects of three-dimensional graphics and their hierarchy. We describe an approach to constructing an array of shapes in a three-dimensional scene, as a result of which the shapes must be placed in the scene in the required way relative to each other with a given step along all axes. To display the object matrix in the scene area, you can perform a circular operation of building shapes for all data extracted from the database. It is concluded that for the correct construction of individual segments in the relative and General coordinate systems should be the same, as well as the need to select a grid for the construction of an array based on geometric models of figures.
DEVELOPMENT OF ELECTRONIC EDUCATIONAL-METHODICAL COMPLEXES OF DISCIPLINES STORAGE SUBSYSTEM OF UNIVERSITY INFORMATION SYSTEM
Authors: Nosova Yu. S. , Molchanov A. N. , Burmistrov A. V. , Grishunov S. S.
Published: May 2019

The article poses the problem of storage, systematization and organization of access to the educational methodological complexes of disciplines (Emcd) in the university. The architecture of the electronic EMCD storage subsystem of the university's information system, consisting of a file storage, a relational database and an application server, is described. The choice of the database management system (dbms) is substantiated and the eer-diagram with the description of the main tables is given. The tools used to develop the server and client parts of the subsystem are described. In particular, the developers used the Python language with the Flask microframework and the CSS framework Bootstrap to create a responsive user interface. The interface of the main pages for working with the subsystem is given, as well as the main types of reports construction.
PROCESS IMPACTS ON RELIABILITY OF PRINTED CIRCUIT BOARDS
Authors: Korotky O. A. , Korneev A. A. , Galkin A. Yu.
Published: May 2019

The paper considers defects that directly affect the quality of the finished product, which includes printed circuit boards and wiring connections. Current problems lead to failures of electronic equipment, which can lead to the failure of complex technical systems with subsequent downtime. Also methods for increasing the reliability of electronic equipment products are proposed, which exclude premature failures of the equipment as a whole. Such failures include breakage of the metallization column during extreme heating of the printed circuit board, poor connection quality of components on the board, absence of a layer between the component and the board. The method of preventing such problems is presented below in the text. Elimination of the above defects can lead to trouble-free operation throughout the warranty period of operation of the equipment at various facilities, including those in the military.
KEY ASPECTS OF CHOICE OF CRYPTOPROVIDER ON MICROSOFT.NET FRAMEWORK BASIS
Authors: Olkhovskiy K. V. , Molchanov A. N. , Burmistrov A. V.
Published: May 2019

The paper reports that cryptographic providers are widely used in cryptographic information security systems used in information systems of electronic document management. The technology of interaction of applications with a crypto-provider through the system level supported by the operating system and the main interfaces used are described. Important characteristics that affect the choice of developers of a particular crypto provider are considered. The main classes of cryptographic primitives based on the Microsoft.NET Framework and variants of their interaction with various crypto providers that solve the problems of compliance with the accepted standards in the field of cryptographic transformations both in the Russian Federation and abroad are demonstrated.
SYNTHESIS OF CONTROLLERS FOR NONLINEAR CONTROL OBJECTS ON BASIS OF NUMERICAL METHODS FOR SOLVING DIFFERENTIAL EQUATIONS
Authors: Kornyushin Yu. P. , Akimenko D. A. , Kornyushin P. Yu.
Published: May 2019

The algorithm of parametric synthesis of regulators for nonlinear control objects is presented in the article, in which knowledge of the real trajectory of the system motion is not required in an explicit form. The essence of the algorithm is as follows: the dynamic properties of the control system are always determined by the right-hand side of the system of differential equations written in the normal form of Cauchy. Depending on the values of the regulator parameters that are also included in the right-hand side, the system of equations may have one or another solution. If we substitute the reference trajectory into the scheme of numerical integration of differential equations describing the dynamics of the system, then at each step of integration it can be considered as a system of algebraic equations for the desired parameters of the regulator. For each discrete value of the reference signal, there is a set of desired regulator parameters from which the desired values are determined, for example, as weighted averages over the entire study interval, or, as some limiting values. In the proposed algorithm, in an implicit form, the criterion of optimality is the norm in the space of convergent numerical sequences.
METHODS OF JAMMING INTERFERENCE
Authors: Mazin A. V. , Aliyev M. Yu.
Published: May 2019

The article investigates the problem of providing high noise immunity radar under the influence of passive and intentional interference. The purpose of radio operation of the radar is to create conditions that would impede the operation of systems and minimize its effectiveness. The main method of radio transmission is still creating (staging) interference. Modern radar systems must solve the tasks in terms of electronic suppression using, including intentional interference and under severe time constraints. It is shown that the most effective way to improve the noise immunity of radar systems designed to operate in multipoint space, including non-stationary, interference is adaptive space-time processing of the received signals, based on the angular selection of targets, due to the formation of zeros in the directional diagram in the direction of interference sources. This problem is solved by determining the accuracy of the direction finding of interference sources and is achieved by the joint operation of the antenna array and multi-channel signal processing devices, namely the separation of interference signals on different receiving channels.
ANALYTICAL MODEL OF TRANSFORMATION OF INHOMOGENEITY OF REMINDER MEDIUM OF CIRCULAR FORM IN CHANGE OF RECEIVER SIGNAL WHILE INTERACTING WITH A GAUSSIAN BEAM
Authors: Butaev М. М.
Published: May 2019

The objects of the study are the methods for calculating the shape of the reproduction signals from the inhomogeneities of a roundshaped medium by a Gaussian beam; the subjects of the study are methods for calculating the values of the convolution function of a two-dimensional Gaussian function with a generalized circle function. The goal is to improve the methods for calculating the waveform from the inhomogeneity of the medium by a Gaussian beam and similar methods of calculating the probability. In the derivation of the analytical model of the waveform generated by the interaction of the inhomogeneity of a circular medium with a Gaussian beam, the methods of the theory of special functions and probability theory are applied. An analytical model of the waveform formed during the interaction of the inhomogeneity of a circular medium with a Gaussian beam is developed, which takes into account the beam dimensions and the inhomogeneity radius, as well as the interrelation of the beam centers and the inhomogeneity. An analytic function of the waveform form from the inhomogeneity of the recording medium, which has the form of a circle, is obtained as a two-dimensional Weierstrass transform from a generalized function in the form of a series on the basis of modified Bessel functions. Recommendations for calculating the function on a computer are given. The graphics of the playback signal of the information storage device on the optical disk for some values of the variables are constructed. A proposal is made to use the obtained analytic function in probability theory.
ANALYSIS OF ADDITION OF DATA IN INFORMATION PROCESSING AND DECODING GROUND SYSTEM
Authors: Starostin E. V. , Sergina I. G.
Published: May 2019

This article discusses the question of adding data in the information processing and decoding ground system. The scheme of registration of messages by the onboard registration device is resulted. Describes the subsequent recording of registered messages in binary files. For processing the received files the information processing and decoding ground system parses messages by their type. The problem of adding a large amount of data to the database management system «Linter-VS» 7.0. The article identifies and describes various methods of adding data, their advantages and disadvantages. To estimate the execution time of the data loading process was chosen the model of the messages registration system. The table of results of adding data by the various methods is presented and the histogram demonstrating comparison of adding data by different methods are given.
USE OF COMPLEX OF ELECTROMAGNETIC ANALYSIS OF PACKAGED PRODUCTS FOR ASSESSING ELECTROMAGNETIC COMPATIBILITY OF ELECTRONIC DEVICES
Authors: Gorbunov A. S. , Zinovyev D. M. , Vostokov N. G. , Gorbunov Al. S.
Published: May 2019

The article describes the experience of using a complex electromagnetic analysis of cased products based on the near-field electromagnetic radiation scanner to assess the electromagnetic compatibility of electronic devices. The structural scheme of the complex and its main characteristics are presented, which consist of the characteristics of the scanner itself and the characteristics of the connected spectrum analyzer. Descriptions of preparations for the re-installation and configuration of application software for managing the scanner. The above formula for calculating the time to scan, the algorithm for the operation of the device, the characteristics of the measuring sensors included in the delivery package and the features of working with the complex. The results of spectral and spatial analysis of electronic devices are shown with a 3D pattern of electromagnetic field intensity distribution. Conclusions are drawn based on the analysis of construction of operational experience.
ANALYTICAL EVALUATION OF PROCESSING TIME OF A QUERY IN AN INFORMATION SYSTEM
Authors: Butaev M. M. , Tarasov A. A.
Published: May 2019

The normal distribution of a random variable is usually used in studies of the probabilistic characteristics of information systems. However, the approximation by the normal distribution of distributions determined on a limited interval distorts the physical meaning of the model and the numerical results, and it can only be used as an initial approximation. The aim of the work is to improve the methods for calculating the probabilistic characteristics of information systems. The object of the study is an analytical method for calculating the processing time of the query in the system. The subject of the study are formulas for calculating the duration of sequential processing of the query by elements of the system with uniformly distributed random processing times. In deriving the formulas for calculating the probability characteristics of a sum of independent uniformly distributed random variables, the methods of the theory of probability and statistics are applied. It is proposed for random variables, determined only on the positive coordinate axis, to use finite-interval distribution laws, for example, beta distribution. Density formulas and probability functions for sums of two, three and four independent uniformly distributed random variables are derived.
QUANTITATIVE VALUES OF TARGET FEATURES ESTIMATION TECHNIQUE ACCORDING TO WIDEBAND RADAR SOUNDING
Authors: Kapylov E. L. , Neyolov V. V. , Samorodov A. A.
Published: May 2019

In civil and special application radar systems broadband radar technologies are widespread. Electrodynamic computer simulation is used for development of modern radar systems. It’s important to study new effective ways of detailed radar image analysis for automatic radar identification. The conventional approach to a radar imaging and a data visualization is based on the Fourier transform method. This method has restrictions and it’s hard to identify close scattering centers because of a fan‑shaped structure. The paper considers a spectral evaluation method based on eigen value analysis of autocorrelation data matrix for processing broadband radar data. Radar length and intensity of scattering centers of a radar target are evaluated by MUSIC method. The main advantage is an ability to identify scattering centers within one resolution element (resel). In order to demonstrate the ability of the developed method broadband frequency characteristics of two typical radar targets are calculated. Intensity and relative distance of scattering center can be more over evaluated with a high accuracy. Stability testing of results to white noise is given.
MATHEMATICAL MODELING OF RFID TAG BY SAW TECHNOLOGY
Authors: Vinogradova S. V. , Chebachev V. O.
Published: May 2019

The mathematical model of RFID SAW tag is under consideration. A model is defined as impulse response of electrical circuit. The factors which influence to tag’s response are analyzed. A program which simulates RFID response receiver was produced. A single radio pulse and compound radio signal modulated by Barker code are used for flexing. The influence for receiving of such factors as temperature, phase uncertainty between SAW transducers and amplitude ripple between responses of different SAW transducers are estimated. The results of this estimation are displayed. Optimal threshold values are estimated for each of flexing signals. It was resulted that the influence of amplitude ripple factor for response is different using single or complex signal for flexing. Methods of compensation the influence of each factor during receiving and operating the signal are reviewed.
VARIABILITY OF ARTERIAL PRESSURE AT SHORT-TERM TIME INTERVALS
Authors: Zakharov S. M.
Published: May 2019

The time and spectral analysis of blood pressure signals (BP of systolic, diastolic, pulse) obtained in real time and reflecting the work of the heart at short time intervals is presented. As a time interval, a sequence of one hundred cardiac cycles was chosen. The main parameters of variability are determined. The proposed method of analysis is an analogue of heart rate variability (HRV), based on the study of RR cardiointervals. Spectral analysis of blood pressure signals shows differences in the degree of orderliness or disorder of individual frequencies or the spectrum as a whole. The presented methodology will allow to reveal further features for use in the diagnosis of various pathologies.
REGISTRATION OF MOTION PARAMETERS OF AIRCRAFT MEASURING POINT AT PARALLEL PLACEMENT OF MOBILE RADAR STATIONS FOR COMPLEX OF EXTERNAL MEASUREMENTS
Authors: Sentsov A. A. , Polyakov V. B. , Dmitriev V. F.
Published: May 2019

The paper presents a practically implemented version of the placement of posts for the complex of external measurements on the basis of mobile radar centimeter range stations, built on the technology of cascaded active phased waveguide‑slot antenna arrays for recording the parameters of the aircraft measuring point as a typical air moving object. The main technical characteristics of the posts for the complex of external measurements and registration of the parameters of motion parameters of air objects are proposed, the restrictions on the range of measurement and review sectors are determined. The influence of environment on the propagation conditions of radio waves, limiting the choice of the frequency range of radar stations, the results of the calculation of linear attenuation in oxygen, water vapor and the total attenuation for the wave range from 10 to 100 GHz are presented. The theoretical issues of designing radar stations sector review with the use of electronic scanning and rangefinder‑goniometer method of measurement are raised.
TWO-SCALE MODIFICATION OF CONICAL SCANNING DIRECTION FINDING METHOD
Authors: Bludov A. A. , Gorbatovsky G. A. , Pavlov V. S.
Published: May 2019

The paper considers a generalized case of conical scanning method, in which the cross‑section of the antenna beam has an elliptical shape. Such feature of the antenna beam shape leads to the occurrence of additional information contained in the received signal. It is shown that by utilizing this information it is possible to form an estimate of the direction to object at large off‑center angles. A modification of the conical scanning method is proposed that combines the estimates of object’s angular position, obtained via standard computational procedure (main scale) and additional procedure for angle estimation based on the additional direction‑finding information contained in the received radar signal envelope (additional scale). The technical result of the introduced two‑scale modification of the conical scanning method consists in a significant expansion of the operational area of direction finding compared to the original method.
ADAPTIVE CORRELATOR IN NON-EMITTING RADAR SYSTEMS
Authors: Ksendzuk A. V. , Kozlov K. O.
Published: May 2019

The paper discusses a new method of processing information in non‑emitting radar systems, whose work is based on the use of a signal from third‑party sources – television and radio broadcasting transmitters, as well as cellular base stations. An adaptive correlator for such radar stations is proposed. The method is based on the analysis of the autocorrelation function (ACF) of a transmitter signal and the adaptive formation of detection areas, based on the properties of the current ACF. Statistical quality parameters were introduced to evaluate the developed method and these parameters were estimated for the DVB‑T2 (Digital Video Broadcasting – Terrestrial) signal, in particular, the achievable characteristics by the side lobes of the lag time uncertainty function for such a signal are shown. It is noted that several adaptive correlators should be simultaneously implemented in non‑radiant radar. The results of processing real data confirm the effectiveness of the proposed method.
STUDY ON INTRODUCTION OF ELECTRONIC SIGNATURE IN ENTERPRISE
Authors: Borsuk N. A. , Fedorova V. A. , Minina A. D.
Published: May 2019

Thanks to modern software, production efficiency can be improved several times. At the same time, the use of software related to documentation entails the ambiguity in the issue of coordination and approval of documents requiring verification. Thus, the system implemented to minimize paper workflow, by default, does not allow to sign it and / or send it for review for approval and other decisions. This paper proves the possibility of solving this problem by introducing an electronic signature in the enterprise. Analysis of the enlarged model of the enterprise allows you to determine the scope of electronic signature in industrial processes. Presents the parameters of the electronic signature, as well as the algorithm for the selection of parameters with justification for the choice of each of them. Provides information on the certification center, necessary for the implementation and maintenance of electronic signatures in a stable state. The practical implementation of the main actions with an electronic signature is shown.
AUTOMATED SEARCH OF SOFTWARE ERRORS BY FAZZING METHOD
Authors: Minaev V. A. , Mazin A. V. , Baidin G. S.
Published: May 2019

The paper considers fuzzing as a promising method of testing and error detection in software using the input of incorrect data to programs. Classification of the automated systems of errors search in the software with indication of their shortcomings is made. The substantiation of errors search advantages under the name Driller is given. The stages of Driller cyclic operation are considered including test data input, actual fuzzing, mixed execution and fuzzing repetition. It is emphasized that the Driller is an open source project. In addition, attention is drawn to the possibility of the specified program to eliminate the «exponential explosion» of considered execution paths number, and it effectiveness at a multiplicity of crossings between the paths of the program under test. It was shown that the Driller allows to effectively solve the problems of information security.
SEARCH AND INDEX DATA USING ELASTICSEARCH
Authors: Fedorova V. A. , Efremov E. A. , Kolyagina I. A.
Published: May 2019

Currently, the use of traditional information retrieval methods for analyzing big data is becoming ineffective. Analysis and processing of a large amount of information require completely new conceptual solutions, one of which is Elasticsearch, a search engine based on the Lucene library. Elasticsearch uses the concept of inverted indexing to speed up searches when a list of all unique words is created for each document and a list of documents for each word. The paper considers the principles of the Elasticsearch search technology. The actual task is to analyze and identify the specific capabilities of the Elasticsearch system associated with the search and processing of large amounts of information. The paper also describes examples of the work of Elasticsearch, which will help professionals to solve problems inherent in the systems of relevant and personalized information retrieval.
DEVELOPING FISCAL DATA PROCESSING ANALYTICAL SYSTEM
Authors: Vershinin Ye. V. , Prokofyev M. L. , Afanasyev V. R.
Published: May 2019

The paper deals with the task of designing an analytical system for processing fiscal data. From a business point of view, such a system should solve the problem of analyzing a market basket, that is, finding the most typical patterns of purchases. From the point of view of data mining, the task of searching for association rules is solved, which consists of two stages: the search for all frequent sets with their support values and the acquisition of association rules based on the sets found. The first stage is provided by various search algorithms for frequent sets. In the paper, the algorithm chosen is the Frequent Pattern Growth Strategy (FPG) as the optimal one. The mathematical formulation of the task and the method for implementing the selected algorithm within the target system are given. The result of the work is a description of the fault‑tolerant and scalable model of the analytical system.
Does the Mundell-Fleming Model Apply to Australia’s Economy?
Authors: Hsing Yu
Published: May 2019

Applying an extended Mundell-Fleming Model to Australia, this paper finds that expansionary fiscal policy does not affect output whereas expansionary monetary policy raises output. In addition, a higher real stock price, a lower real oil price or a lower expected inflation rate would increase output. Hence, the predictions of the Mundell-Fleming model works for Australia’s economy.
AUTHENTICATION OF PATIN (PANGASIUS MICRONEMUS) FISH OIL ADULTERATED WITH PALM OIL USING FTIR SPECTROSCOPY COMBINED WITH CHEMOMETRICS
Authors: Putri Anggita Rosiana , Rohman Abdul , RIYANTO SUGENG
Published: May 2019

Objective: The goal of this research was to perform authentication of patin (Pangasius micronemus) fish oil (PFO) adulterated with palm oil (PO) using FTIR spectroscopy combined with chemometrics method.

Methods: Patin fish oil (PFO) and PFO adulterated with palm oil (PO) were measured using FTIR instrument at wavenumbers region of 4000–650 cm-1. The chemometrics methods, namely multivariate calibration of partial least square (PLS) and principal component regression (PCR) were used to make calibration and validation models during quantification. Discriminant analysis (DA) was used to make grouping pure PFO and PFO adulterated with PO.

Results: The results showed that PLS and PCR could be used to quantify PO as adulterant in PFO, either in calibration or validation models. FTIR spectroscopy combined with multivariate calibration offered accurate and precise method for quantitative analysis with R2 value of >0.999 and low RMSEC and RMSEP. DA was capable of grouping PFO and PFO adulterated with PO with an accuracy level of 100%.

Conclusion: FTIR spectroscopy combined with chemometrics could be reliable technique for quantification and discrimination of PFO and PFO adulterated with PO.
HUMIC SUBSTANCES AS A POTENT BIOMATERIALS FOR THERAPEUTIC AND DRUG DELIVERY SYSTEM-A REVIEW
Authors: JACOB KALA K , KJ PRASHOB PETER , N CHANDRAMOHANAKUMAR
Published: May 2019

Efficiency of therapeutic compounds could be enhanced by encapsulation and covalent attachments to a biomaterial carrier. Complex formation with humic substances is valuable techniques to improve bioactivity of natural products. Fractal structures of humic substances also have adjacent carboxyl and hydroxyl groups. Along with molecular bonding property, reduction-oxidation and association-dissociation capacities of humic substances are considered this as a biomaterial for transform, other molecules, and substances. Immune system responses of humic acid stimulates in the human body. However, pharmaceutical importance of humic substances, demands on evidenced efficacy and a clearly defined chemical composition of the preparations used. Toxicological safety standards also have to be evaluated. This review summarises the application of humic substances as pharmaceuticaly important biomaterial. Research on this zone opened up an application for humic substances in pharmacogonasy.
RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF ASIATIC ACID ISOLATED FROM THE PLANT CENTELLA ASIATICA.
Authors: Hebbar Srinivas , Dubey Akhilesh , G. S. RAVI , Kumar Hemanth , Saha Santhanu
Published: May 2019

Objective: Asiatic acid is a triterpene saponin and the main constituent of the species Centellaasiatica. The current study aimed to isolate, characterize and develop an analytical method for asiatic acid in the shorter run time with good efficiency.

Methods: In this study isolation of asiatic acid was achieved by TLC and thus isolated asiatic acid was characterized by 1HNMR spectral analysis and LCMS. An isocratic RP-HPLC method was established for the assessment of asiatic acid from the methanol extract of Centellaasiatica. The chromatographic separations were achieved by RP-C18 column 250x4.6 mm (5µ Particle size) Shimadzu UFLC pump LC 20AD and mobile phase composed of 0.1% orthophosphoric acid: acetonitrile (50:50). The analysis of column effluents was achieved using a PDA detector (Photo Diode Array) at 210 nm, and the flow rate was recorded 1 ml/min.

Results: Soxhlet extraction process followed by fractional extraction using different solvents was performed. Methnol extract was taken to isolate asiatic acid by TLC (RF 0.97) and base peak from mass spectra was found to be 489M+which was confirmed successful isolation. Retention time of asiatic acid was found to be 9.6±0.22 min. This method obeyed linearity over the concentration range of 10-50µg/ml and regression coefficient was obtained from the alinearity plot for asiatic acid which was found to be 0.9987 LoD and LoQ were obtained to be 0.784507µg/ml and 2.615µg/ml respectively. RSD of mean assay values was found to be 1.02%. Since there were no marked changes in the performance characteristics of the method.

Conclusion: Isolation, characterization and identification of asiatic acid were achieved significantly which will be useful for the standardization of herbal formulation containing asiatic acid.
SYNTHESIS AND CHARACTERIZATION OF THIOLATED JACKFRUIT SEED STARCH AS A COLONIC DRUG DELIVERY CARRIER
Authors: Das Sanjoy , Das Malay K.
Published: May 2019

Objective: Site-specific drug delivery into the colonic region is extremely fascinating for local treatment of various colonic diseases like ulcerative colitis, colon cancer but it should be capable of saving the drug from hydrolysis and degradation. The present study reports the application of jackfruit seed starch and its thiol derivative as a drug delivery carrier for the colon.

Methods: The starch was extracted from the jackfruit seeds by water extraction method and modified by the esterification reaction with thioglycolic acid. The thiolated starch was characterized for morphology, functional and flow properties. The safety profile of the thiolated starch was confirmed by acute toxicity study in a mice model as per OECD guidelines 423. The microspheres based on thiolated starch were prepared by ionic gelation method incorporating Ibuprofen as a model drug. The prepared microspheres were characterized for particle size, drug entrapment efficiency, drug loading, compatibility study, surface morphology, in vitro drug release and release kinetics.

Results: The result attributed that starch was successfully modified by the thiolation with a degree of substitution of 3.30. The size of prepared microspheres ranges from 825.5±4.58 to 857±6.24 µm, the entrapment efficiencies ranges from 69.23±1.19 to 76.15±0.83 % and the drug loading capacity ranges from 17.75±0.30 to 46.05±0.49 %. The FT-IR, DSC and XRD studies confirmed that there is no interaction within drug and excipients. The thiolated starch microspheres show the maximum release of drug at pH 7.4 in the presence of rat caecal content as compared to pH 1.2 and pH 6.8 for up to 24 h and are following first order release kinetics.

Conclusion: These results suggest the application of thiolated jackfruit seed starch could be promising as a long-term drug delivery carrier for the colon.
HPLC METHOD DEVELOPMENT FOR THE ANALYSIS OF BISOPROLOL IN COMBINED DOSAGE FORM CONTAINING BISOPROLOL AND ENALAPRIL AND IN VITRO DISSOLUTION STUDIED
Authors: Logoyda Liliya , Kovalenko Sergiy , Abdel-Megied Ahmed M. , Zhulkevych Igor , Drapak Iryna , Demchuk Inna , Netsyuk Oleh
Published: May 2019

Objective: A simple, rapid and reproducible HPLC method was developed for the determination of bisoprolol in experimental combined dosage forms containing bisoprolol and enalapril and for drug dissolution studies.

Methods: A C18 column (Hi Qsil C18, 5 μm, 4.6х250 mm) and a mobile phase methanol: phosphate buffer solution (65:35, v/v) mixture were used for separation and quantification. Analyses were run at a flow rate of 1.0 ml/min and at ambient temperature. The injection volume was 300 μL and the ultraviolet detector was set at 225 nm. The method was validated as per ICH guidelines.

Results: Under these conditions, bisoprolol was eluted at 4.75 min. Total run time was shorter than 6 min. A linear relationship between the concentration and the area of ​​chromatographic peaks of bisoprolol in the range of 0.625 mg/ml-5.000 mg/ml (3.750 mg/ml at pH 1.2) has been established. In the medium with pH 1.2 release of bisoprolol from tablets in 5 min is 38.42%, and after 15 min-85.51%, in medium with pH 4.5 the release of bisoprolol from tablets in 5 min makes 59.78%, and after 15 min-103.71%; in a medium with pH 6.8, the release of bisoprolol from tablets in 5 min is 61.29%, and after 15 min-85.90%.

Conclusion: The developed method was applied successfully for quality control assay of bisoprolol in experimental tablets and in vitro dissolution studies.