bluuebunny/crossref_metadata_2025 huggingface dataset:
Diffuse partial woolly hair.
Authors: Guidetti M S , Fanti P A , Piraccini B M , Barbareschi M , Tosti A
Published: June 2023

We report here a 14-year-old girl with diffuse partial woolly hair. The patient presented mild hair loss associated with the presence of fine, short and kinky hairs closely interspersed with the normal hair throughout the scalp. The pathology of the scalp revealed the presence of intermediate-sized hair follicles regularly intermingled with normal follicles in each follicular unit. The possibility that diffuse partial woolly hair may result from a progressive miniaturization of the hair follicles may explain the presence of evident hair thinning in several adult patients affected by this rare abnormality.
Expression of transglutaminase I in human anagen hair follicles.
Authors: Tamada Y , Takama H , Kitamura T , Ikeya T , Yokochi T
Published: June 2023

The expression of the transglutaminase I in human anagen hair follicles was studied by an immunohistochemical staining. In the bulbar and suprabulbar portions of anagen hair follicles, transglutaminase I was detected on the hair cuticle and the three layers of the inner root sheath. Subsequently, the positive staining became translocated to the inner site of the outer root sheath in the middle part of the hair follicle. In the upper portion of the hair follicle transglutaminase I was detected in the internal part of the outer root sheath and the surface epidermis. Therefore, it was suggested that the expression of transglutaminase I might be closely associated with the terminal keratinization in the anagen hair follicles.
Skin barrier properties in patients with recessive X-linked ichthyosis.
Authors: Johansen J D , Ramsing D , Vejlsgaard G , Agner T
Published: June 2023

Patients with X-linked recessive ichthyosis (RXLI) were studied as a model of the effect of disturbed epidermal lipid composition on skin barrier function. Thirteen patients with RXLI and 15 age- and sex-matched controls were patch-tested with sodium lauryl sulphate (SLS) 0.5% for 24 h. Basal skin properties and skin response to SLS were studied by measurement of transepidermal water loss (TEWL), electrical capacitance and erythema index. No statistically significant difference in basal TEWL was found between the two groups. The skin response to SLS was found to be statistically significantly increased in controls compared to ichthyosis patients, when evaluated by TEWL. When evaluated by erythema index a statistically significant increase in redness was found in controls, but not in ichthyosis patients. Electrical capacitance, reflecting skin hydration, was significantly reduced in RXLI patients as compared to controls. The water permeability barrier in RXLI patients was not found to be impaired, and skin reactivity was found to be decreased in RXLI patients as compared to controls.
In vitro T cell response to staphylococcal enterotoxin B superantigen in chronic plaque type psoriasis.
Authors: Bour H , Demidem A , Garrigue J L , Krasteva M , Schmitt D , Claudy A , Nicolas J F
Published: June 2023

Recent studies have demonstrated the important role of CD4+ T cells in the pathophysiology of psoriasis. One of the current hypotheses is that triggering of the psoriatic inflammatory process could be secondary to CD4+ T cell activation by bacterial superantigens in the skin. In this study, IL-2-derived T cell lines were recovered from the blood and the skin of 4 patients with chronic plaque type psoriasis and of 2 patients with allergic contact dermatitis (ACD). Blood and skin T cell lines were tested for their ability to proliferate in vitro to staphylococcal enterotoxin B (SEB) presented by MHC class II expressing antigen-presenting cells. The results showed a significantly higher SEB-induced T cell proliferation in skin T cell lines as compared to blood T cell lines in 3 out of 4 psoriatic patients and in one of the 2 ACD patients. No difference between the skin and blood T cells for their response to phytohemagglutinin was observed. Furthermore the blood T cell lines from both patients and control individuals responded equally well to SEB. Thus psoriatic skin T cell lines were characterized by an enrichment in SEB-responding T cells. Since similar enhancement of SEB-responsive T cells was occasionally found in ACD patients, we propose that SEB could be an environmental factor associated with rather than responsible for psoriatic inflammation.
Mucocutaneous fungal colonization in HIV-infected children.
Authors: Don PC , Shen N N , Koestenblatt E K , Sierra M F , Stone R K , Bamji M
Published: June 2023

The prevalence of symptomatic mucocutaneous candidiasis in HIV-infected children is well documented. Information, however, of the carriage rate of potential fungal pathogens is lacking. In this study we determined the fungal colonization rate of multiple mucocutaneous sites from 13 HIV-infected and 12 control children. The rate of yeast and mould colonization and the species of fungal isolates were essentially the same for both groups of patients. However, several HIV-infected children asymptomatic for thrush proved to be colonized by Candida albicans, and disseminated colonization with Trichosporon beigelii occurred in one HIV-infected child. All cultures for dermatophytes were negative. While the carriage rate with fungi other than C. albicans was not increased in the HIV-infected group, the isolates recovered are known pathogens in the immunocompromised host and the colonization of these organisms may be a potential source of infection.
ELISA inhibition test using monoclonal antibody specific for Treponema pallidum as the serologic test for syphilis.
Authors: Whang KK , Lee MG , Song MS , Lee JB
Published: June 2023

Monoclonal antibodies (Mabs) specific for Treponema pallidum were produced using hybridoma technology. In this study an ELISA inhibition test based on competitive inhibition by antibodies from human test sera of the binding of the enzyme-labelled Mabs to T. pallidum was performed. Inhibition of the seroreactivity of Mabs was decreased according to the dilution of rabbit antiserum to T. pallidum. Seropositivity was found in 100% of secondary and early latent syphilis patients, 75% of primary syphilis patients, and 80% of late latent syphilis patients. The mean percentage inhibition was significantly higher in each syphilis group than in the controls, and statistically significant differences were shown between all the syphilis groups. VDRL and TPHA titers were correlated with the percentage inhibitions. Therefore the ELISA inhibition test using Mab specific for T. pallidum might well be a suitable tool as a new serologic test for syphilis.
Cutaneous complications in heart transplant recipients in Norway 1983-1993.
Authors: Jensen P , Clausen O P , Geiran O , Simonsen S , Relbo A , Hansen S , Langeland T
Published: June 2023

All Norweigian heart transplant recipients with more than one year's survival (n = 140) were investigated for dermatological disorders. Observation time after transplantation was 1-10 years (mean 5.0 years). Patients alive at the end of 1993 (n = 122) were examined clinically, and medical records for all patients were reviewed. The histopathological diagnoses of excised skin specimens were reevaluated. Malignant skin tumours (i.e. basal cell carcinoma, squamous cell carcinoma and malignant melanoma) and/or premalignant skin tumours (i.e. morbus Bowen (carcinoma in situ), solar keratosis and keratoacanthoma) were found in 34 patients (24.3%), of which 18 patients (12.9%) had malignant skin tumours. Seventeen lesions diagnosed as keratoacanthoma and two lesions diagnosed as morbus Bowen had primarily been diagnosed as squamous cell carcinoma. Five patients (3.6%) had multiple keratoacanthomas. Other frequent dermatological diagnoses included hypertrichosis (86.9%), steroid-induced skin features (59.8%), common warts (42.6%) and seborrheic skin disorders (20.5%). This study demonstrates the importance of dermatological surveillance in the follow-up of heart transplant recipients.
Pruritogenic effects of mitogen-stimulated peripheral blood mononuclear cells in atopic eczema.
Authors: Cremer B , Heimann A , Dippel E , Czarnetzki B M
Published: June 2023

The etiology of atopic pruritus is unclear and seems mostly histamine-independent. In order to investigate non-mast cells as possible sources of pruritogenic agents, peripheral blood mononuclear cells from 12 atopic eczema patients and 12 controls were incubated in vitro for 24 h with phytohemagglutinin or concanavalin A (both at 10 micrograms/ml) or with medium alone, and each subject was tested with his own cell supernatants and lysates by prick testing and by application on tape-stripped skin. Histamine (0.1%) and substance P (500 microM) were tested in comparison, and reactions were observed for up to 24 h. Cell supernatants were also analysed for their contents of several cytokines. Lymphocyte cell extracts or supernatants failed to cause symptoms in controls but induced whealing in 6 and itching in 3 patients on prick testing within 5 min, lasting for 30 min in 2 patients and persisting for 6 h in 1 patient. Histamine caused itching in all controls and in 7 patients within 5 min on prick testing, with decreasing reactivity at later times. Substance P yielded results with lower values. With all three types of test reagents, fewer subjects reacted on tape stripped skin. High levels of interleukins 2 and 6, low levels of interferon and no detectable levels of interleukin 4 and tumour necrosis factor were measured in stimulated cell supernatants and extracts, with even lower levels in subjects exhibiting skin reactivity. These findings thus provide evidence that as yet unidentified mononuclear cell products may be involved in whealing and itching associated with atopic eczema.
Single cilia in human epidermis are susceptible to challenge.
Authors: Warfvinge K
Published: June 2023

Single cilia were found in melanocytes and basal keratinocytes in normal epidermis and in epidermis subjected to various types of exposure. Quantitative electron microscopy showed that about 31% of the melanocytes and 71% of the keratinocytes from normal skin possessed a ciliary apparatus, but there was a wide individual variation. A statistically significant decrease in the number of ciliated keratinocytes followed exposure to nickel, sodium lauryl sulphate, UVA and UVB irradiation. There was no statistically significant difference between controls and skin subjected to various exposures regarding the number of ciliated melanocytes. We have earlier reported that single cilia are frequently seen on epithelial cells capable of mitotic activity in human oral and vaginal epithelia. The present study showed that single cilia react to external exposures. The cilium might be a sensitive, easily damaged organelle, or the decrease in ciliated cells might reflect a change in normal mitotic activity as a result of exposure.
Functional changes in human stratum corneum induced by topical glycolic acid: comparison with all-trans retinoic acid.
Authors: Effendy I , Kwangsukstith C , Lee J Y , Maibach H I
Published: June 2023

The effects of topical glycolic acid and all-trans retinoic acid on stratum corneum barrier function and hydration of human skin were investigated in 6 healthy volunteers utilizing non-invasive techniques. In addition, changes in stratum corneum turnover time induced by the substances were examined using the dansyl chloride fluorescence test. Twelve percent glycolic acid in water and 0.1% retinoic acid in ethanol, respectively, were applied for 60 min once daily, over a period of 2 weeks (5 consecutive days weekly) on dansyl chloride-labelled skin and on untreated skin. During a 10-day application period, both glycolic acid and retinoic acid similarly induced a significant increase in TEWL. However, after discontinuing treatment, TEWL in retinoic acid-exposed skin remained increased. Glycolic acid significantly reduced stratum corneum hydration from day 11 to day 18 (p < 0.05), while retinoic acid induced skin dryness after 9 days of treatment, which persisted until day 18 (p < 0.005). Whereas glycolic acid rapidly induced an intense erythema implying a direct non-specific inflammatory response, the retinoic acid-exposed skin gradually developed erythema. Retinoic acid caused scaling to a greater extent than did glycolic acid, even after treatment cessation. Both glycolic acid and retinoic acid significantly decreased stratum corneum turnover time and stratum corneum turnover time50 (the time in days from labelling until approximately 50% of fluorescence disappeared), compared with the vehicle controls. However, glycolic acid shortened stratum corneum turnover time (12.8 +/- 0.9 days) as well as stratum corneum turnover time50 (7.3 +/- 0.7 d) significantly more than did retinoic acid (15.8 +/- 0.7 d and 9 +/- 0.8 d, respectively). While ethanol (vehicle of retinoic acid) slightly but significantly decreased stratum corneum turnover time (p < 0.05), water (vehicle of glycolic acid) did not. This study showed that both glycolic acid and retinoic acid induced certain functional changes in stratum corneum, mirroring their irritation potential. However, changes at retinoic acid-exposed sites appeared longer-lasting, implying a distinct mode of action. An increase in stratum corneum turnover induced by the substances may be, in part, linked with their irritation properties.
Solar pruritus.
Authors: Bech-Thomsen N , Thomsen K
Published: June 2023

A case of solar pruritus is reported. Severe pruritus of the back, shoulders and upper lateral aspects of the arms, without any eruption, developed in a 28-year-old outdoor worker during 4 to 6 weeks of intensive solar exposure. The pruritus was intense and described as a burning sensation deep in the skin. Only a few excoriations and slight xerosis were found. Solar pruritus or brachioradial pruritus is a condition primarily seen in Caucasian people living in the tropics or subtropics. Previously the disease has only been reported once outside these areas.
Metabolic carotenemia and carotenoderma in a child.
Authors: Svensson A , Vahlquist A
Published: June 2023

We describe a 3-year-old girl with long-standing yellow discoloration of her skin and a 3-fold increase in the plasma carotenoid concentration compared to normal, but no history of excessive carotene intake or familial carotenemia. When put on a carotene-deficient diet for 8 months she still had some remaining yellow discoloration in the nasolabial folds and on the palms and soles. The results of an oral loading with beta-carotene (1 mg/kg) provide indirect evidence that the girl's carotenemia is due to a probably genetic defect in the metabolism of carotenoids.
The effect of calcipotriol on lesional fibroblasts from patients with active morphoea.
Authors: Bottomley W W , Jutley J , Wood E J , Goodfield M D
Published: June 2023

We examined the responsiveness of cultured dermal fibroblasts from biopsies of 6 patients with active morphoea and a similar number of matched controls to the cell proliferation inhibition activity of calcipotriol. Cultured fibroblasts from controls showed no significant response to calcipotriol (at concentrations of 1 x 10(-8) to 1 x 10(-4) M). However, calcipotriol did inhibit the proliferation response of morphoea fibroblasts at all concentrations when compared with controls. There was 4- to 20-fold inhibition in 2 of the morphoea patients when compared with control samples. Four other morphoea samples showed inhibition but to a lesser extent compared with controls.
Sodium hydroxide-induced irritant dermatitis as assessed by computerized elaboration of 20 MHz B-scan images and by TEWL measurement: a method for investigating skin barrier function.
Authors: Seidenari S , Pepe P , Di Nardo A
Published: June 2023

Sodium hydroxide-induced irritation was studied in 34 volunteers, by means of 24-h patch testing at different concentrations, and by a 10-min testing procedure employing 0.1 mol/l NaOH. As a supplement to subjective evaluation of skin changes, assessments of test areas by TEWL measurement and sonography were performed at 24, 48 and 72 h. After 24-h patch testing, instrumental evaluations showed an increase in the extension of the hypo-echogenic dermal area and in TEWL, whereas a 10-min NaOH application induced a decrease of the dermal and epidermal reflectivity and an increase in TEWL. Twenty-four hour patch testing with 4% NaOH allowed a classification of subjects into two categories: subjects who reacted normally and hyper-reactors. Hyper-reactors showed an enhanced inflammatory response and a more pronounced barrier function damage, as assessed clinically and instrumentally by decreased dermal reflectivity, and by higher postexposure TEWL. Subjects with a more marked inflammatory response to 4% NaOH also showed greater TEWL increases during the short-term testing procedure employing 0.1 mol/l NaOH. Moreover, these subjects were characterized by higher baseline TEWL values, indicating that cutaneous reactivity to NaOH is at least partly correlated to impaired stratum corneum function, which is inadequate to effectively prevent compounds from penetrating the skin.
A case of actinic granuloma associated with periumbilical perforating pseudoxanthoma elasticum.
Authors: Lee HW , Park MA , Lee SC , Won YH , Chun IK.
Published: June 2023

We report an unusual case of actinic granuloma of the face and periumbilical perforating pseudoxanthoma elasticum located superior to the umbilicus in a 57-year-old Korean woman. Histopathologically, these two dermatoses have a similar degeneration of elastic fibers, but they show different host reactions to the altered elastic fibers. In the actinic granuloma, actinically damaged elastic fibers were followed by granulomatous infiltration on the sun-exposed area, while in the perforating pseudoxanthoma elasticum, the altered elastic fibers induced a foreign body reaction, with subsequent transepidermal elimination. This is the first case report showing both actinic granuloma and periumbilical perforating pseudoxanthoma elasticum in the same patient, which suggests that the basic mechanism eliciting these dermatoses is similar.
Hailey-Hailey disease with acrokeratosis verruciformis Hopf.
Authors: Yakis G , Csató M , Kemény L , Korom I , Morvay M , Dobozy A.
Published: June 2023

No abstract available
Patch test study with calcipotriol ointment in different patient groups, including psoriatic patients with and without adverse dermatitis.
Authors: Fullerton A , Avnstorp C , Agner T , Dahl JC , Olsen LO , Serup J.
Published: June 2023

One hundred and sixty-eight individuals (psoriatic patients treated with calcipotriol with dermatitis due to calcipotriol, psoriatic patients treated with calcipotriol with no dermatitis, psoriatic patients never treated with calcipotriol, patients with eczema and healthy volunteers) were patch-tested (Finn chambers, back, 48 h) with dilutions of calcipotriol ointment (50, 10, 2, 0.4 micrograms/g) and an ointment vehicle. Test evaluation was based on clinical scoring and various non-invasive measuring methods. Doubtful (?+) and weak (1+) reactions were common, irrespective of patient group and history. Moderate (2+) reactions were uncommon and with no increased frequency among psoriatic patients with adverse dermatitis during calcipotriol treatment. The blood flow of test sites measured by laser Doppler flowmetry was, however, increased in psoriatics, who developed dermatitis during calcipotriol treatment as an isolated finding. Furthermore a 1-week repeated open application test (ROAT) was performed on all subjects. None of the persons having a strong reaction in the patch test showed any dermatitis in the ROAT test, indicating that they were not sensitized. Calcipotriol was found to be a mild irritant of the non-corrosive type, i.e. with no influence on the skin barrier. Reactions were dominated by redness (increased laser Doppler flow and chroma a*) and only oedema formation in advanced reactions. The calcipotriol dose-irritation curve was found to be scattered. Calcipotriol induced no increase of transepidermal water loss (TEWL) versus the ointment vehicle, but the ointment vehicle itself increased TEWL. The special ointment vehicle needed for calcipotriol for stability reasons may itself be irritant and cause some impairment of the skin water barrier, with increase in TEWL values. Future patch test studies for calcipotriol allergy should not be done with this vehicle. The non-irritant threshold concentration of calcipotriol in an appropriate test vehicle is still unknown.
Acrodermatitis chronica atrophicans in an Italian child.
Authors: Menni S , Pistritto G , Piccinno R , Trevisan G.
Published: June 2023

No abstract available
Multiple symmetrical lipomatosis in a patient on long-term corticosteroid therapy.
Authors: Khanna N , Dogra D , Rathi SK , Ravindraprasad JS.
Published: June 2023

No abstract available
Ethanol enhances the mitogen-driven lymphocyte proliferation in patients with psoriasis.
Authors: Schopf RE , Ockenfels HM , Morsches B.
Published: June 2023

Ethanol has been reported to exacerbate psoriasis. Since immunological mechanisms are considered to be important for the pathogenesis of psoriasis, we compared the effects of ethanol on lymphocyte proliferation in 15 healthy control individuals and 15 patients with psoriasis. We employed the spontaneous and phytohemagglutin in (PHA)-induced uptake of 3H-TdR to measure lymphocyte proliferation. Ethanol was added to cultures at concentrations ranging from 0.5 to 0.0005% (vol./vol.). We found that both spontaneous and PHA-driven lymphocyte proliferations were significantly lower in patients with psoriasis (P < 0.002). Spontaneous blastogenesis in both controls and patients remained stable under ethanol. In controls, ethanol suppressed the PHA-driven lymphocyte proliferation in a dose-dependent fashion. By contrast, in patients with psoriasis ethanol significantly increased lymphocyte proliferation by 2-3 times (p < 0.002). Our data indicate that in psoriasis the lower lymphocyte transformation is abnormally enhanced by minimal doses of ethanol.
Delayed-type hypersensitivity in palmoplantar pustulosis: effect of cyclosporin A treatment on skin testing with recall antigens.
Authors: Remitz A , Lauerma AI , Erkko P , Reitamo S.
Published: June 2023

Delayed-type hypersensitivity reactions to skin antigens are an indirect measure of cellular immune response. We studied in a double-blind manner whether clinically effective doses of cyclosporin A in palmoplantar pustulosis would diminish delayed-type hypersensitivity reactions in vivo. For testing delayed-type hypersensitivity, we applied intradermally a standardized panel of seven recall antigens and a vehicle control in 30 patients with palmoplantar pustulosis, and 28 were tested both at baseline and after 4 weeks. For 4 weeks 14 patients were treated with 2.5 mg/kg/day cyclosporin A and 14 patients with placebo. Cyclosporin A but not placebo caused a significant decrease in clinical disease parameters. In contrast, no significant differences in delayed-type hypersensitivity reactions between treatment groups were observed. The results do not support the view that the efficacy of low-dose cyclosporin A in dermatological disorders can be entirely explained by cyclosporin A's inhibitory actions on effector T-cells.
Foil bath PUVA in the treatment of prurigo simplex subacuta.
Authors: Streit V , Thiede R , Wiedow O , Christophers E.
Published: June 2023

Prurigo simplex subacuta is a chronic pruritic condition of unknown aetiology. The skin lesions respond to topical corticosteroids, UV-A and UV-B therapy only to a limited degree. Ten patients suffering from prurigo simplex subacuta were treated with foil bath PUVA at a concentration of 0.5 mg 8-methoxypsoralen/l. Using the foil bath method the volume of the psoralen/bath-water solution is restricted to 10 l with the aid of polyethylene foil. The group required a median of 13 (95% CI: 9-19) baths for clearance. The total UV-A dose for the whole group was 19 (95% CI:5-30) J/cm2. Bath PUVA is a safe and well-tolerated therapy in the treatment of prurigo simplex subacuta.
Multiple facial cylindromas in twins.
Authors: Cucurell M , Diaz C , Barranco C , Giménez-Arnau A , Camarasa JG.
Published: June 2023

No Abstract available.
Soluble interleukin-2 receptor (sIL-2R) is a marker of disease activity in psoriasis: a comparison of sIL-2R, sCD27, sCD4, sCD8 and sICAM-1.
Authors: De Rie MA , Zonneveld IM , Witkamp L , Van Lier RA , Out TA , Bos JD.
Published: June 2023

Psoriasis is a T-cell-mediated inflammatory skin disease which can be treated successfully with immunosuppressive drugs. Our purpose was to evaluate disease activity of psoriasis and the effect of immunosuppressive treatment by monitoring the soluble T-cell products sIL-2R, sCD27, sCD4, sCD8 and sICAM-1. Twenty-two patients were treated orally with escalating dosages of cyclosporin A (n = 17)(3-5 mg/kg/day) or FK506 (n = 5)(0.05-0.15 mg/kg/day). The Psoriasis Area and Severity Index (PASI) was used to monitor clinical activity of psoriasis. Serum samples were analyzed by ELISA. sIL-2R levels showed the highest correlation with psoriasis disease activity (rs = 0.89
Lobular panniculitis associated with venous congestion in right-sided heart failure.
Authors: Husebye ES , Pontén F , Wibell L.
Published: June 2023

No abstract available.
Treatment of hand dermatosis: a comparative study of a topical glucocorticoid ointment vs solution occluded with a new thin hydrocolloid dressing.
Authors: Beitner H.
Published: June 2023

No abstract available.
Plasma endothelin in psoriasis: possible relations to therapy and toxicity.
Authors: Zachariae H , Heickendorff L , Bjerring P.
Published: June 2023

Plasma endothelin levels were studied in 71 patients suffering from severe psoriasis. The psoriatics were treated either with topical therapy alone (n = 18) or with cyclosporin A (n = 26), methotrexate (n = 21), or with hydroxyurea, acitretin or ranitidin (n = 6) with or without topical therapy. The psoriatics had a significantly higher average plasma endothelin than 40 healthy controls. The patients treated with cyclosporin A had the highest values and these were in contrast to patients on methotrexate and other systemic therapy higher than patients treated with topical therapy alone. There was not significant difference between endothelin levels in patients treated with methotrexate compared to those in patients only receiving topical treatment. Whether the increased endothelin levels in plasma are derived from keratinocytes or enlarged vessels need to be investigated. An increased plasma endothelin level could be related to therapy and for patients on cyclosporin A be of importance for toxicity.
The in vitro effect of fluconazole on the filamentous form of Pityrosporum ovale.
Authors: Faergemann J , Bratel AT.
Published: June 2023

The antimycotic activity of fluconazole against the filamentous form of Pityrosporum ovale was studied in vitro. P. ovale was grown on human stratum corneum in vitro with and without the addition of different concentrations of fluconazole. In control cultures hyphae were produced in 25% of the cells compared to only 4% after exposure to fluconazole 1 microgram/ml. In control cultures 16% of the fungal cells showed signs of necrosis, due to the normal turnover rate of the cells, compared to 65% of the fungal cells exposed to 1 microgram/ml of fluconazole. In the transmission electron microscope the typical thick-walled fungal cells with their characteristic budding were observed in control cultures. However, after exposure to 1 microgram/ml of fluconazole that P. ovale cells showed extensive signs of necrosis, with loss of internal organelles and disinterruption of the cell wall. The results obtained in this in vitro model mimic the in vivo situation in pityriasis versicolor. There is a parallel between the good results obtained in this system and the good clinical effect of fluconazole in Pityrosporum-related diseases.
Successful treatment of dyshidrotic hand eczema using tap water iontophoresis with pulsed direct current.
Authors: Odia S , Vocks E , Rakoski J , Ring J.
Published: June 2023

The efficacy of tap water iontophoresis in treating palmoplantar hyperhidrosis has been sufficiently documented and has led to its extensive use in clinical practice. In order to test the efficacy of this treatment modality in cases of dyshidrotic hand eczema, 20 patients were treated with tap water iontophoresis in addition to two-sided steroid-free topical therapy in a randomized half-side-study. A special score for dyshidrotic eczema including objective and subjective criteria was developed to document the success of the therapy. Only those sides treated with tap water iontophoresis showed significant improvement. This significant effect of iontophoresis indicates the efficacy of this treatment in cases of dyshidrotic hand eczema.
n-Docosanol 10% cream in the treatment of recurrent herpes labialis: a randomised, double-blind, placebo-controlled study.
Authors: Habbema L , De Boulle K , Roders GA , Katz DH.
Published: June 2023

n-Docosanol has been shown to have antiviral activity. To demonstrate the efficacy of n-docosanol 10% cream in the treatment of recurrent herpes labialis, a randomised, double-blind, parallel group, placebo-controlled study was undertaken in 63 patients. In a crossover extension, 22 of the patients used the alternative treatment for a further episode. A total of 98 episodes were evaluated. Application of n-docosanol 10% cream early in the prodromal or erythema stage of a recurrent episode of herpes labialis shortened mean healing time by approximately 3 days, as compared to late treatment with n-docosanol 10% cream and early or late treatment with the placebo. The crossover study revealed that late treatment with n-docosanol 10% cream significantly reduced mean healing time compared to placebo. Treatments were well tolerated.
A case-control study of hidradenitis suppurativa in an STD population.
Authors: Jemec GB , Heidenheim M , Nielsen NH.
Published: June 2023

The prevalence of hidradenitis suppurativa has been found to be higher among patients attending an STD clinic than in an unselected general population sample. The aetiology of hidradenitis in unknown, but an association with chlamydial infections has been suggested for perineal lesions. Our aim was to describe the history of STD, STD risk factors and possible current STD in patients with hidradenitis. A case-control study comparing patients with hidradenitis (20) and controls (60) was therefore made in patients attending an STD clinic. Genital HPV infection was found to be more common in patients with hidradenitis (p = 0.036), but no differences were seen in the history of STD, STD risk behaviour or other current STD between the two groups studied. HPV infection appears to be the only STD which is more common in hidradenitis patients, but the biological significance of this finding is not clear. It is speculated that common predisposing factors may be responsible. We were unable to support the previously postulated association between Chlamydia trachomatis infection and hidradenitis.
Bullous pemphigoid and diabetes mellitus.
Authors: Rosina P , Chieregato C , D'Onghia FS.
Published: June 2023

No abstract available
Clofazimine in inflammatory facial dermatosis--granuloma faciale and lipogranulomatosis subcutanea (Rothmann-Makai).
Authors: Wollina U , Karte K , Geyer A , Stuhlert A , Bocker T.
Published: June 2023

No abstract available.
Discoloration of the nail plate due to the misuse of amorolfine 5% nail lacquer.
Authors: Rigopoulos D , Katsambas A , Antoniou C , Christofidou E , Balaskas E , Stratigos J.
Published: June 2023

No abstract available.
Immunological features of chronic adult paracoccidioidomycosis: report of a case treated with fluconazole.
Authors: Pereiro Jr M , Pereiro M , García García , Toribio J.
Published: June 2023

No abstract available.
Reactivation of healed primary syphilitic ulcer: a manifestation of febrile Herxheimer reaction in secondary syphilis.
Authors: Khanna N , Pandhi RK.
Published: June 2023

No abstract available.
Duct disruption, a new explanation of miliaria.
Authors: Shuster S.
Published: June 2023

From argument and a few personal observations, the hypothesis has crystallised that the miliaria commonly occurring in unacclimatised Caucasians visiting hot climates is caused by exposure to ultraviolet irradiation, by an effect on the cells of the upper epidermis, which eventually allows a split to develop between them and the new stratum corneum that grows up beneath, into which sweat from the disrupted ducts can collect as microcysts. This dehiscence is the probable explanation of sunburn peeling and photo-onycholysis. It is concluded that duct disruption, not blockage or dysfunction, is the immediate cause of the miliarias.
The peripheral resistance in arteries of legs is inversely proportional to the severity of chronic venous insufficiency.
Authors: Malanin K , Haapanen A , Kolari PJ , Helander I , Havu VK.
Published: June 2023

There are conflicting reports in the literature about the existence of arteriovenous shunting in legs with chronic venous insufficiency. Using duplex scanning, we have earlier shown that there is lowered peripheral resistance in the arteries of legs with venous ulcer together with premature venous filling in angiography. In the present study we investigated the peripheral resistance in the arteries of 16 legs with chronic venous insufficiency without present ulcer. We compared the results with those obtained from 12 healthy legs and from 18 legs with venous ulcer. There was a highly significant inverse correlation between the severity of chronic venous insufficiency and the peripheral resistance in the popliteal, the dorsal pedal and the posterior tibial arteries (p < 0.001). These results suggest that there is arteriovenous shunting in legs with chronic venous insufficiency and that this phenomenon correlates with the degree of chronic venous insufficiency.
DNA-ploidy abnormalities are a reflection of the metastatic potential of malignant melanoma. Microfluorometric DNA analysis.
Authors: Umebayashi Y , Otsuka F.
Published: June 2023

Using DAPI (4',6-diamidino-2-phenylindole)-DNA microfluorometry, we examined the nuclear DNA-ploidy abnormalities of 15 primary malignant melanomas and their 20 corresponding metastases. They all presented the aneuploid DNA histographic pattern. When the DNA index value was calculated as the reflection of DNA-ploidy abnormalities, it was found to be significantly higher in the metastases (2.07 +/- 0.50) than in the primary tumors (1.76 +/- 0.50) (p < 0.01). Sixteen (80%) of the metastatic tumors had a higher DNA index value than their primary tumors, whereas the remaining four (20%) had a lower value. The difference in the DNA index values between the primary and metastatic tumors did not correlate to any other conventional prognostic variables (e.g. histologic type, level, and thickness). When we added 15 non-metastatic melanomas to the above 15 primary melanomas and evaluated the predictors for metastasis using multivariate stepwise logistic regression analysis, the DNA index value of the primary melanomas was found to be the most reliable risk factor. These results suggest that primary melanoma cell populations, having high DNA index values, are usually responsible for subsequent metastasis, and that hence, DNA-ploidy abnormalities of primary melanomas are likely to provide useful information for patient potential with regard to metastasis.
Urticaria: increasingly recognised but not adequately highlighted cause of dyspareunia and vulvodynia.
Authors: Lambiris A , Greaves MW.
Published: June 2023

No abstract available.
Notalgia paresthetica, macular posterior pigmentary incontinence, macular amyloidosis and pruritus.
Authors: Bernhard JD.
Published: June 2023

No abstract available.
Minocycline-induced acute generalized exanthematous pustulosis in a patient with generalized pustular psoriasis showing elevated level of sELAM-1.
Authors: Yamamoto T , Minatohara K.
Published: June 2023

No abstract available.
Scedosporium apiospermum skin infection in a patient with nephrotic syndrome.
Authors: Ichikawa T , Saiki M , Tokunaga S , Saida T.
Published: June 2023

No abstract available.
A study of coagulation and anti-endothelial antibodies in idiopathic livedo reticularis.
Authors: Faclieru D , Bergman R , Lanir N , Friedman-Birnbaum R , Brenner B.
Published: June 2023

Livedo reticularis is associated with collagen vascular diseases and other vaso-occlusive disorders in a substantial number of cases. In the remaining cases the cause of livedo reticularis is still unknown. (i.e., idiopathic). We sought to determine a possible causal relationship between idiopathic livedo reticularis and autoimmune factors associated with the coagulation system, including antiendothelial cell antibodies. Nine patients with idiopathic livedo reticularis were studied. All patients were found to have normal platelet count, fibrinogen levels, and prothrombin and activated partial thromboplastin times, as well as negative results for Venereal Disease Research Laboratory and D-timer tests. Anticoagulant activity was detected in 2 patients: one had positive results of thromboplastin titration index and Russell's viper venom test, as well as increased levels of anticardiolipin antibodies and anti-endothelial cell antibodies
Immunoblot analysis of autoantigens in localized pemphigoid and pemphigoid nodularis.
Authors: Kawahara Y , Matsumura K , Hashimoto T , Nishikawa T.
Published: June 2023

We analyzed circulating antibodies in sera from patients with localized pemphigoid and pemphigoid nodularis, two variants of bullous pemphigoid, by means of western immunoblotting of human epidermal extracts and the recombinant protein of NC16a domain of the 180 kD bullous pemphigoid antigen. NC16a domain is now considered to be the most pathogenic site of bullous pemphigoid. Compared with the results of typical bullous pemphigoid patients, localized pemphigoid sera detected the 180 kD bullous pemphigoid antigen less frequently, and sera from both localized pemphigoid and pemphigoid nodularis showed a lower end point of titer of antibodies to NC16a domain. These results suggest that atypical clinical features of the two bullous pemphigoid variants may be related with low titer of autoantibodies to 180 kD bullous pemphigoid antigen, particularly to NC16a domain.
The dermal type of erythema multiforme: a rare variant of Stevens-Johnson syndrome or cases of clinical misclassification?
Authors: Hering O , Mockenhaupt M , Rzany B , Schröder W , Schöpf E.
Published: June 2023

Since 01.04.90 the Dokumentationszentrum schwerer Hautreaktionen (dZh) in Freiburg has registered cases of severe skin reactions like erythema exsudativum multiforme majus, Stevens-Johnson syndrome and toxic epidermal necrolysis in Germany. With the largest study so far of histological slides from patients included in this registry we were able to show that the epidermal type of erythema multiforme described by Orfanos et al. is the histopathological correlated of these severe skin reactions. Except two biopsies all of the specimens taken from the registered patients showed histological characteristics of this type of erythema multiforme. These two cases are now reported. Clinical data and photographic documentation did not prove authentic erythema multiforme. The lesions of both patients were described as atypical macules and papules
Cutaneous infection due to Mycobacterium abscessus. A case report.
Authors: Vogels MT , Tjan-Heijnen VC , Alkemade JA , Beex LV , Muytjens HL.
Published: June 2023

Erythematous nodular and ulcerating skin lesions occurred in a 56-year-old woman treated with chemotherapy and glucocorticosteroids for metastatic breast cancer. Subsequent culture yielded Mycobacterium abscessus, a facultative pathogen which exists as a saprophyte in the environment and rarely produces clinical disease in humans. This organism is usually relatively resistant to antituberculous as well as a number of other antimicrobial agents. On the basis of in vitro susceptibility results, treatment with clarithromycin and clofazimine was installed and resolution of the lesions initiated. This report emphasizes once again that one should investigate any new or unusual skin lesions in immunocompromised patients by histology and culture of biopsies, including cultures for acidfast organisms.
Lesional mRNA expression of Th1 cytokines in adult T-cell leukemia/lymphoma.
Authors: Koga T , Fugimura I , Miyata T , Katsuoka K , Shimizu A , Toshitani S.
Published: June 2023

No abstract available
Abnormal corneometric values of non-lesional plaque-type psoriatic skin.
Authors: Mussi A , Carducci M , Bonifati C , Fazio M , Ameglio F.
Published: June 2023

No abstract available
The interaction between stratum corneum and dermatophytes in patients with chronic tinea pedis.
Authors: Bergström A , Faergemann J.
Published: June 2023

No abstract available
Syringocystadenoma papilliferum, basal cell carcinoma and trichilemmoma arising from nevus sebaceus of Jadassohn.
Authors: Yoon DH , Jang IG , Kim TY , Kim HO , Kim CW.
Published: June 2023

No abstract available
Paraneoplastic pemphigus associated with pancreatic carcinoma.
Authors: Matz H , Milner Y , Frusic-Zlotkin M , Brenner S.
Published: June 2023

A case of paraneoplastic pemphigus associated with pancreatic carcinoma is presented. The histopathological and immunological features of the case, which are consistent with and differ from the accepted diagnostic criteria, are discussed.
Semi-quantitative measurements of body hair in hirsute women compare well with direct diameter measurements of hair shafts.
Authors: Barth JH.
Published: June 2023

No standards exist for the evaluation of hair in hirsute women. This study compared the semi-quantitative visual scoring of body hair, using the Ferriman & Gallwey scale, in 88 hirsute women with direct objective measurements of hair shaft diameter and daily linear growth rates of hair growing on the pre-auricular area of the face, the forearm, the anterior abdominal wall and the anterior thigh. There was a significant correlation between the semi-quantitative score and diameter measurements on the forearm, abdominal wall and thigh. There was no relationship between linear growth rates at any of the four sites and the semi-quantitative score. The conclusion of this report is that suitably standardised and controlled semi-quantitative measurement of hair in hirsute women with visual analogue scores would appear to offer information similar to that obtained by direct measurement of hair diameter.
Desmoplastic trichilemmoma: a case report with immunohistochemical characterization of the extracellular matrix components.
Authors: Massi D , Franchi A.
Published: June 2023

The case of unusual desmoplastic variant of trichilemmoma arising in the neck of a 56-year-old man is reported. The tumour was characterized by the presence of a densely sclerotic stroma, surrounded by lobules of epithelial cells with features of outer root sheath differentiation, including glycogen-rich, clear cytoplasm and peripheral palisading. In the central part of the tumour, irregular cords of epithelial cells entrapped in the desmoplastic stroma were found. Differential diagnosis of this rare tumour includes invasive squamous cell carcinoma, morphealike type basal cell carcinoma, desmoplastic trichoepithelioma and desmoplastic trichoblastoma. By immunohistochemistry, the tumour epithelium stained with anti-cytokeratin antibodies while the stromal cells were positive with vimentin. The centro-tumoral extracellular matrix showed a diffuse and intense positivity for type I collagen and tenascin, whereas stains for laminin and type IV collagen were uniformly negative. We suggest that tenascin could be secreted by the epithelial neoplastic cells and play a role in the mesenchymal response, which results in desmoplasia.
Phorbol-myristate-acetate, but not interleukin-1 beta or insulin-like growth factor-I, regulates protein kinase C isoenzymes in human dermal papilla cells.
Authors: Eicheler W , Huth A , Happle R , Hoffmann R.
Published: June 2023

The in vitro growth of human hair follicles is inhibited by interleukin (IL)-1 beta and phorbol esters, such as phorbol-myristate-acetate (PMA), but enhanced by insulin-like growth factor (IGF)-I. Although this process is only incompletely understood, the dermal papilla as a pivotal part of the hair follicle is almost certainly involved. Since protein kinase C (PKC) isoenzymes are activated by phorbol esters and are key enzymes in signalling pathways of several hormones, neurotransmitters, and growth factors, we addressed the question whether the action of the above-mentioned hair growth-modulating substances may affect PKC isoenzymes in cultured dermal papilla cells (DPC). By Western blot analysis, protein kinase C alpha, -epsilon, -gamma, -iota, -lambda, and the RACK1 receptor protein were detected in dermal papilla cell cultures, whereas the isoenzymes delta and mu were expressed only at low levels and protein kinase C-beta, -theta, and -zeta, were not present. After PMA stimulation, the PKC alpha, -epsilon, and -gamma were translocated from the cytosol to the membrane fraction and subsequently down-regulated. PKC iota was down-regulated but not translocated, and PKC lambda and RACK1 were not affected by PMA. Neither, IL-1 beta nor IGF had an effect on PKC or RACK1 expression. We conclude that cultured DPC express a distinct PKC isoenzyme pattern and that the PMA-induced growth arrest in cultivated hair follicles may be transmitted via protein kinases, whereas the effects of IL-1 beta or IGF may be transduced via other signal transduction pathways or other cell types.
Evaluation of the clinical usefulness of measuring urinary excretion of 5-S-cysteinyldopa in melanoma: ten years' experience of 50 patients.
Authors: Sasaki Y , Shimizu H , Naka W , Takeshita E , Nishikawa T.
Published: June 2023

The urinary excretion of 5-S-cysteinyldopa (5-S-CD) is known to be increased in certain patients with melanoma. To evaluate its diagnostic and prognostic utility, we measured the urinary excretion of 5-S-CD on at least three different occasions in 50 patients with melanoma. No significant increase was found in 26 patients without metastases, in 10 patients with regional lymph node metastasis and 2 patients with amelanotic melanoma. However, all the 12 patients with distant metastases demonstrated a significant increase. The patients with 5-S-CD > 1,000 micrograms/day survived for a mean of 8.1 +/- 5.6 months, while those with 5-S-CD > 10,000 micrograms/day survived for 3.5 +/- 3.7 months. All the 4 patients with a maximum excretion of 5-S-CD > 40,000 micrograms/day had multiple liver metastases. In conclusion, while data on the urinary excretion of 5-S-CD was not useful in the detection of early regional lymph node metastases, its increase indicated the presence of distant metastases and also provided prognostic information.
Does addition of topical calcipotriol to UVB increase the risk of irritant reactions in psoriasis? The Calcipotriol-UVB Study Group.
Authors: Molin L.
Published: June 2023

No Abstract available
Scar depigmentation in systemic sclerosis.
Authors: Ramam M , Dogra D.
Published: June 2023

No Abstract available