bluuebunny/crossref_metadata_2025 huggingface dataset:
Durable and Drastic Response to the Trastuzumab, Letrozole, Abemaciclib, and Goserelin Combination as First-Line Therapy in HER2-Positive and Hormone Receptor-Positive Metastatic Breast Cancer: A Case Report
Authors: Suwanvecho Suthida , Kiatikajornthada Narongsak , Phikulsod Ployploen , Suwanrusme Harit , Jirawatnotai Siwanon
Published: January 2025

Introduction: Chemotherapy combined with anti-human epidermal growth factor receptor 2 (HER2)-targeted therapy is currently a standard treatment for advanced HER2/HR-positive breast cancer (BC), although evidences showed that HR expression compromised effectiveness of the treatment. While cyclin-dependent kinase (CDK) 4/6 inhibitors combined with endocrine therapy is a key therapy for the BC with HR expression, data on the effectiveness and safety of CDK 4/6 inhibitors combined with trastuzumab and endocrine therapy as a first-line treatment for HER2-positive and HR-positive metastatic BC are limited. Case Presentation: Here, we report a case of a 46-year-old premenopausal woman diagnosed with stage 4 HER2/HR-positive invasive ductal carcinoma from both right and left breast with hypermetabolic activities in multiple lymph nodes, adrenal, bone, and skin. Interventions: Due to the patient’s refusal to use chemotherapy, she was started on goserelin, abemaciclib, letrozole, and trastuzumab. Outcomes: The patient’s symptoms were relieved with near resolution of the primary breast mass and nearly all of the metastatic sites. Metabolic resolution was observed in bone lesions. The disease was under control for 57 weeks. During the treatment, neutropenia (grade 1–2) and anemia (grade 1) occurred, which spontaneously recovered. Additionally, diarrhea improved after symptomatic treatment. Conclusion: We believe that the combination of trastuzumab, hormone suppression, and abemaciclib is a practicable and effective treatment for HER2-positive and HR-positive metastatic BC in premenopausal patients who cannot tolerate the first-line chemotherapy.
Comprehensive Interventions in HBV Care: Nursing-Sensitive Approach
Authors: Zhang Juan , Xie Xinger , Qi Longju
Published: January 2025

Objectives: To evaluate the impact of a comprehensive intervention using nursing-sensitive quality indicators on pregnant women with hepatitis B and their newborns.
Design: A randomized controlled monocentric trial conducted from January 2020 to May 2022.
Participants/Materials: 80 pregnant women diagnosed with hepatitis B were randomly assigned to either a control group (n=40) or an experimental group (n=40). The experimental group received care-sensitive quality indicators during treatment.
Setting: Department of Traditional Chinese Medicine, Nantong Third People's Hospital, affiliated with Nantong Hospital 3 of Nantong University, Jiangsu, China.
Methods: Participants in the experimental group received daily Tenofovir from late pregnancy to early postpartum, and newborns received hepatitis B vaccine and immunoglobulin within 24 hours of birth. Healthcare personnel underwent six months of training on care-sensitive quality indicators. The effectiveness of the intervention was assessed using various indicators such as health education coverage, antiviral medication compliance, follow-up rates, and psychological health.
Results: The results showed that after comprehensive intervention, the coverage rate of health education increased from 82.50% before intervention to 92.50% (P=0.033), and adherence to antiviral medication improved from 82.50% to 97.50% (P=0.000). The follow-up rate for hepatitis B mothers also significantly increased from 80.00% to 95.00% (P=0.001). In addition, the incidence of negative emotions such as anxiety and depression among pregnant women significantly decreased from 57.50% to 30.00% (P=0.000). These findings demonstrate the effectiveness of comprehensive interventions in improving health education coverage and participation, enhancing adherence to antiviral medication, and effectively reducing the psychological burden of pregnant women. Moreover, after the intervention, the awareness of mother-to-child transmission prevention for hepatitis B significantly increased from 82.36 points before intervention to 94.32 points after intervention (P=0.000). At the same time, adherence to neonatal immunization increased from 80.00% to 95.00%, and satisfaction with nursing services improved from 90.66 points to 98.64 points (P=0.000). These results indicate that comprehensive interventions significantly enhance knowledge related to mother-to-child transmission prevention, increase immunization adherence, and improve satisfaction with nursing services.
Colitis-Induced Pancreatic Fistula with Pancreatic Ascites
Authors: Winrich Evan , Steele Ethan , Shine Amal , Parajuli Dipendra
Published: January 2025

Introduction: Although cases of severe pancreatitis causing fistula formation into the colon have been documented, the reverse process of colitis causing a pancreatic fistula remains undocumented. Case Presentation: We present the case of a 79-year-old male with severe colitis resulting in perforation and pericolonic abscess formation adjacent to the pancreas, which resulted in an internal pancreatic fistula and pancreatic ascites. After 2 paracenteses, our patient ultimately underwent endoscopic retrograde cholangiopancreatography (ERCP) with sphincterotomy and pancreatic duct stent placement. The patient clinically improved and was ultimately discharged. Conclusion: Follow-up ERCP was performed 2 months after discharge and showed no contrast extravasation, illustrating closure of the previous pancreatic fistula. Ultimately, our case demonstrates that cases of severe colitis may contribute to adjacent pancreatic fistula and ascites formation.
Growth and rhGH use in children with congenital chronic kidney disease: a multicentric contemporary study
Authors: Dubois Séverine , Duneton Charlotte , Salomon Rémi Henri , Ulinski Tim , Boizeau Priscilla , Carel Jean-Claude , Simon Dominique
Published: January 2025

Introduction. Growth retardation is common in children with chronic kidney disease (CKD) and reflects CKD severity. Recombinant human growth hormone (rhGH) treatment was approved for CKD in 1995. We describe here treatment patterns and growth outcomes in children with congenital CKD in three pediatric nephrology departments.
Methods. We included patients with kidney transplantation (KT) performed between 2015 and 2020 at an age of 3 to 18 years. Data were collected at four timepoints: CKD diagnosis, initiation of rhGH, initiation of dialysis, and transplantation.
Results. Among 87 patients, 42 (48%) received rhGH. The median height at treatment initiation was -2.0 SDS, with a median height gain of +0.7 SD (p<0.0001) in 1.7 years. Growth outcomes were negatively associated with older age and CKD stage 5. The 45 rhGH-untreated patients lost 0.6 SD (p=0.02) from diagnosis to transplantation but maintained their height in the normal range. At transplantation, 26% of rhGH-treated and 9% of rhGH-untreated patients had a height SDS below -2 SDS. rhGH was initiated by nephrologists in 52% of cases and endocrinologists in 48%. Deviations from marketing authorization criteria were observed in 68% of cases: endocrinologists typically prescribed rhGH for children under 2 years, while nephrologists prescribed it for patients with a height above -2 SDS.
Conclusion. About half of CKD patients received rhGH treatment, resulting in significant height gain. Untreated patients were not adversely affected in terms of height. These data highlight the importance of careful monitoring of growth and rhGH treatment if needed in patients with CKD.
Mendelian Randomization Analysis Reveals a Causal Relationship Between Membranous Nephropathy and the Gut Microbiome
Authors: Yuan Dunlu , Chen Yuelong , Zheng Hongyun , Liu Guiqun , Yang Qing , Chen Ling , Li Qing
Published: January 2025

Background: With the increasing prevalence of membranous nephropathy (MN), the gut microbiome (GM) is increasingly implicated in its cause, yet the intricate mechanisms remain unclear. Whether changes in the diversity and richness of gut microbial populations among MN patients contribute to disease prevalence is still unanswered, necessitating further exploration into the potential causative link between the GM and MN.
Methods: We conducted a comprehensive bidirectional Mendelian randomization (MR) study. We selected 211 bacterial taxa using Genome-wide association study (GWAS) data provided by the MiBioGen consortium, while GWAS data relevant to MN were obtained from ebi-a-GCST010005. The inverse-variance weighted (IVW) method was the primary technique used to delineate the causal relationship between exposures and outcomes. To confirm the robustness of our results, we used additional methods, including MR-Egger, weighted median, simple mode, and weighted mode. Sensitivity analyses included tests for pleiotropy, heterogeneity, and leave-one-out sensitivity to ensure the integrity of our conclusions. Finally, reverse MR analyses were conducted to assess the likelihood of reverse causality.
Results: Using various analytical methods, including the IVW approach, MR-Egger, weighted median, simple mode, and weighted mode, our study identified six microbial taxa with a statistically significant causal link to MN, as indicated by p-values less than 0.05. The implicated taxa are Butyrivibrio (OR= 1.25, 95 % CI: 1.001-1.565, P = 0.048), Butyricicoccus (OR = 2.15, 95 % CI: 1.005-4.621, P = 0.048), Catenibacterium (OR = 1.49, 95 % CI: 1.043-2.134, P = 0.028), Ruminiclostridium5 (OR = 1.78, 95 % CI: 1.140-2.763, P = 0.03), RuminococcaceaeUCG003 (OR = 1.78, 95 % CI: 1.140-2.763, P = 0.011) and Bacillales (OR = 1.52, 95 % CI: 1.135-2.025, P = 0.005). Each of these taxa has been established as a risk factor for MN. Notably, Ruminococcaceae UCG-003 and Bacillales were identified as having a bidirectional causal relationship with the disease.
Conclusion: Our MR study has revealed a causal link between six microbial taxa and MN, highlighting their potential involvement in the disease's development. These findings represent an initial step into this complex field and underscore the need for more in-depth research.
First record of potential twins and cooperative parental care in the threatened caatinga howler monkey (Alouatta ululata) (Primates)
Authors: Freire-Filho Robério , Teixeira de Andrade Bruna Marcela , Cavalcante Thabata , Veiga Sanjay , Bezerra Bruna
Published: January 2025

Twins are relatively rare in medium- and large-sized primates. It is often a reproductive strategy of small Callithrix species with cooperative social systems to cope with the twin’s care demands. This study reports the first potential record of twins in caatinga howler monkeys and describes parental care related to them. We observed the animals between October 2018 and January 2020 in São Miguel do Tapuio, Piauí, Brazil. The presumed twins were first observed in October 2018. An adult female carried one infant ventrally and the other on the side of her body or on her back. The presumed twins were approx. 1/8 of the female’s body size and estimated to be 5 days old when first detected. The group’s alpha male was vigilant and often remained close to the female and the twins. In February 2019, the size of the infants reached approximately 1/6 of the female’s size and the number of records of infant back carrying reduced by 40% (decreasing from 100 to 60% of records). Nevertheless, when the infants were not being carried, they remained within a few meters of their presumed mother. In February 2019, we observed the alpha male carrying one of the infants while traveling and resting; this suggests that caatinga howler monkey may use cooperative parental care to cope with multiple infants in a group, possibly facilitating their development and survival. When carrying the infants, the presumed mother rested more than the other females in the group. We stopped seeing adults carrying the infants one year after their initial sighting. Their process of gaining independence was gradual.
Description of two new species of Rhaphidophora (Orthoptera: Rhaphidophoridae: Rhaphidophorinae) from Yunnan, China
Authors: YU TINGTING , LIU MINGYU , BIAN XUN , ZHANG BIN
Published: January 2025

This paper describes two new species of Rhaphidophora from Yunnan, China. The illustrations, descriptions and diagnosis are provided based on the specimens deposited in Guangxi Normal University. The two new species have distinctive male epiprocts.
Three new species of Euseius (Mesostigmata: Phytoseiidae) from Tamil Nadu, India, with redescription of Euseius ovalis and key to the Indian species
Authors: BISWAS SHUBHADEEP , KARMARKAR KRISHNA
Published: January 2025

Three new species of the genus Euseius Wainstein, 1962 (Mesostigmata: Phytoseiidae) namely, Euseius aridophilus Karmakar & Biswas sp. nov., Euseius madrasi Karmakar & Biswas sp. nov. and Euseius tamilicus Karmakar & Biswas sp. nov. are described and Euseius ovalis (Evans, 1953) is redescribed based on specimens collected from scrub forest regions of the state of Tamil Nadu, India. A key to the 50 Indian species of Euseius is provided. Euseius aridophilus Karmakar & Biswas sp. nov. is one of the most abundant phytoseiid mite species in the Indian states of Andhra Pradesh, Karnataka, Jharkhand, Odisha, Punjab, and Tamil Nadu.
A new species of the genus Seba (Crustacea: Amphipoda: Sebidae) from a cold seep of Mariana Trench
Authors: TOKUMORI DAIGO , WATANABE HIROMI KAYAMA , TANAKA KATSUHIKO , OHARA YASUHIKO , TOMIKAWA KO
Published: January 2025

A new species of sebid amphipod, Seba marianaensis sp. nov., is described from the Shinkai Seep Field, Mariana Trench, at a depth of 5689–5683 m. Seba marianaensis sp. nov. is most similar to Seba bathybia; however, it differs from S. bathybia by the setation of the mandibular palp and uropod 3 ramus and the shape of the gnathopod 1 coxa. This is the first record of Sebidae from the Mariana Trench.
Carlo Levi 1947–1948 (con uno scritto disperso)
Authors: Contorbia Franco
Published: January 2025

The essay aims to trace the political trajectory of Carlo Levi between his first trip to the United States with Ferruccio Parri, in the spring of 1947, and the 1948 political elections, which followed six months after the dissolution of the Action Party and its merger into the Italian Socialist Party. The author examines Levi’s biography through some of its most significant milestones, illuminated by his correspondence, the important article “Guerra e Pace”, published in L’Italia Socialista and never collected in book form, and his collaboration with Aldo Garosci’s newspaper in the previously unseen role of political cartoonist.
Brian Blount as Eventful Preacher
Authors: Long Thomas G.
Published: January 2025

As an academically trained biblical scholar and as one formed in the Black Church tradition, Brian Blount combines in his preaching attention to the rhetorical power of biblical texts characteristic of recent trends in philosophical hermeneutics with a social hermeneutic born out of the experience of the Black Church. The result is preaching that is eventful in impact, apocalyptic in theological outlook, and interventionist in rhetorical strategy.
Can I Be a Witness? A Testimony and Tribute to Brian K. Blount
Authors: Lettsome Raquel S.
Published: January 2025

In this essay, I will pay tribute to Brian K. Blount by offering a critical personal narrative that explores the profound impact of his book, Cultural Interpretation: Reorienting New Testament Criticism, for my development as a New Testament scholar. Brian’s interpretative model influenced not only my teaching but also my preaching. The interpersonal concerns that I can bring to my interpretation also enrich my proclamation. Therefore, I will conclude this tribute by offering a third sermon, on Mark 16:1–8, my own “happy ending,” to Brian’s book with Gary Charles, Preaching Mark in Two Voices.
Where’s He Going? Mark 6:45–52
Authors: Blount Brian K.
Published: January 2025

A sermon preached by the Rev. Dr. Brian K. Blount on the occasion of Union Presbyterian Seminary’s graduation ceremony on May 27, 2023, in Richmond, Virginia, the year of his retirement as President of the seminary.
Non-graduate entry a retrograde step for the police professionalisation agenda?
Authors: McCanney John , Taylor Julie
Published: January 2025

Since its inception the College of Policing has promoted policing as a profession and it has established a code of ethics, a body of knowledge and graduate entry in pursuit of its ambition. The graduate entry programme has been the subject of criticism and in response a non-graduate entry route has been introduced. Graduate entry is fundamental to most professions and this change could undermine the professionalisation agenda. This article uses a series of focus groups to compare the views of probationary officers from graduate and non-graduate training programme to assess the impact of the graduate entry programme on student officers. While the research found many similarities between the cohorts. IPLDP students expressed a greater affinity with the role of police as crime fighters than their graduate peers. While the graduate students were concerned about limitations on their ability to use their discretion and the extent of their autonomy.
Uncovering the Links Between Problematic Smartphone Usage and Subjective Vitality: The Role of Mindful Parenting and Parenting Stress
Authors: Erus Seher Merve , Satıcı Seydi Ahmen , Deniz M. Engin
Published: January 2025

In recent years, scientific research has increasingly focused on the relationship between parents’ mobile phone usage and parenting. As smartphones have become pervasive among parents, concerns have arisen regarding how this usage might influence parenting practices and well-being. Therefore, studies that examine the relationship between parents’ technology usage—particularly smartphone usage—and their well-being and parenting practices are of significant value. Such research can provide deeper insights into how technology shapes family dynamics and parental roles over time. Our research aimed to investigate the relationships among problematic smartphone usage, mindful parenting, parenting stress, and subjective vitality. The study involved a cross-lagged panel design with two waves of longitudinal research, and parents with at least one child between the ages of 1 and 14 participated. The results revealed that problematic smartphone use has a negative correlation with mindful parenting and subjective vitality, while it has a positive correlation with parenting stress. Serial mediation analysis showed that mindful parenting and parenting stress, both longitudinally and sequentially, mediate the relationship between problematic smartphone usage and subjective vitality. These findings suggest that problematic smartphone use adversely affects parents’ well-being by increasing stress and reducing mindful engagement in parenting. Interventions focusing on reducing problematic smartphone use and enhancing mindful parenting practices may improve parental well-being and reduce stress.
Research status of simulation modeling technology for the 3D braiding process
Authors: Yuan Chengxu , Li Xin Rong , Zhang Shijie , Li Shun , Ma Kui
Published: January 2025

Three-dimensional (3D) braiding has excellent mechanical properties due to its unique spatial organization, in which simulation modeling of the braiding process is a key technology to study the complex spatial structure of 3D braided fabrics. The paper first summarizes the research methods of 3D braiding simulation modeling technology in recent years; second, it focuses on the analysis of numerical method modeling based on geometric dynamics, geometric modeling based on the braiding process, and modeling based on the finite-element method; then, based on the existing technology and application status quo, it sums up the advantages and shortcomings of the current 3D braiding process simulation modeling technology; and, finally, it describes the challenges and opportunities of the 3D braiding simulation modeling technology. The future development direction of the three modeling methods and the new idea of mutual coupling of the three methods are proposed and future development prospects are described. The paper provides technical support for the simulation modeling of the braiding process in 3D braiding technology.
How religious identity affects life satisfaction of Afghan immigrants in Turkey: The role of social support and discrimination
Authors: Güler Abdurrahim , Kaya Faruk , Öztürk Akif , Avcil Ceren , Kayserili Alperen
Published: January 2025

This study investigates the relationship between religious identity and life satisfaction, exploring the potential mediating roles of perceived social support and perceived discrimination. The study included 182 Afghan immigrants (age range: 18–65 years, with mean age = 29.73 ± 9.16) residing in Agri, Turkey. They completed self-reported measures of religious identity, perceived social support, perceived discrimination, and life satisfaction using a paper-and-pencil format. The results suggest that religious identity is positively associated with perceived social support and negatively associated with perceived discrimination and that both perceived social support and perceived discrimination play fully mediating roles in the relationship between religious identity and life satisfaction. Individuals with a stronger religious identity are more likely to experience higher levels of perceived social support and lower levels of perceived discrimination, which, in turn, contribute to greater life satisfaction. The findings suggest that both perceived social support and perceived discrimination explain the relationship between religious identity and life satisfaction. These findings have important implications for individuals and communities seeking to enhance life satisfaction among migrants with strong religious identities and highlight the significance of considering perceived social support and perceived discrimination as key mediators in the relationship between religious identity and well-being.
Good Jobs or Bad Jobs? Immigrant Workers in the Gig Economy
Authors: Liu Cathy Yang , Renzy Rory
Published: January 2025

New work arrangements enabled by online platforms, or gig work, saw substantive growth during the COVID-19 pandemic. Various estimates have suggested the wide participation of workers in the gig economy, with minority and immigrant workers well represented. The quality of work is a multi-dimensional concept that goes beyond earnings. One framework of good jobs and bad jobs centers on control over work schedule, content and duration, stability, safety, benefits and insurance, as well as career advancement opportunities. Using a newly released national survey focused on entrepreneurs and workers in the United States, we find that about 18.5 percent immigrant workers and 21.1 percent native-born workers participated in the gig economy as their primary or secondary job. In terms of job quality, immigrant gig workers work shorter hours and have significantly less fringe benefits than non-gig workers as well as U.S.-born gig workers, reflecting a double disadvantage. However, they tend to have higher entrepreneurial aspirations, suggesting the transient nature of gig arrangements and potential for career advancements. This paper provides a comprehensive analysis of the characteristics and implication of immigrants’ engagement with the gig economy and offers policy and theoretical discussions.
It's a Non-binary World (After All): The Effect of Intersectionality on Transgender Consumers Experiencing Vulnerability
Authors: Marangoni Vívian Silva Lima , Ferraz Sofia Batista , Veloso Andres Rodriguez , Hildebrand Diogo Fajardo Nunes , Lopes Lealis Vaz Meleiro
Published: January 2025

Minorities may experience increased vulnerability due to overlapping marginalizations at the individual and institutional levels. Intersectionality is crucial in understanding how additional triggering factors promoting higher vulnerability levels can alter individuals’ life trajectories. Through in-depth interviews with 25 participants, we explore how intersecting identities—such as gender, socioeconomic status, education, and race—create vulnerability. We contribute to the literature on consumer vulnerability by introducing the duality of consumer responses, distinguishing between positive actions that reduce vulnerability and negative ones that perpetuate harm, and identifying how intersectionality accelerates vulnerability.
Prospective study on the role of preoperative mannitol in capsulorhexis and reducing intraoperative complications in primary angle-closure disease surgery
Authors: Liang Zhiqiao , Li Hongyan , Hou Xianru , Yang Kangyi , Lv Kun , Ma Yao , Lu Ye , Wu Kuankuan , Wu Huijuan
Published: January 2025

Objective

To evaluate the effect of preoperative intravenous mannitol on the capsulorhexis process and intraoperative complications in patients with primary angle-closure glaucoma (PACG).

Methods

In this prospective randomized controlled trial, 65 PACG eyes were randomized into the mannitol and control groups. The capsulorhexis duration, number of forceps grasps, need for viscoelastic re-injection, and intraoperative complications were recorded.

Results

The mannitol group had a significantly shorter capsulorhexis duration and fewer forceps grasps of the capsule. All intraoperative complications (18.2%) occurred in the control group. The patients with intraoperative complications had significantly higher intraocular pressure and lower best-corrected visual acuity than those without complications after surgery. Multivariate analysis found that intravenous mannitol (odds ratio [OR] = −14.263; 95% confidence interval [CI] =−26.713 to −1.813) reduced the capsulorhexis duration, whereas zonulopathy (OR = 14.477, 95% CI = 2.622–26.331) prolonged the duration.

Conclusion

Preoperative intravenous mannitol can reduce the risk of intraoperative complications and improve postoperative outcomes in patients with PACG. Factors including anterior chamber depth, incision location and method, and the zonule status significantly influence the capsulorhexis process.
Unbureaucratic Behavior in Times of Crisis: Rule-Breaking by Public Administrators
Authors: Lenz Alexa , Eckhard Steffen
Published: January 2025

During crisis management, public administrators typically adjust bureaucratic rules to become more flexible. In this paper, we go one step further, asking about the factors that explain rule-breaking behavior among public servants during crisis management. We report novel qualitative evidence and findings from a preregistered randomized quasi-experiment surveyed among 448 public servants in Germany. Our findings reveal that bureaucrats’ prosocial attitudes, whether the affected population is part of their in-group and higher levels of red tape affect significantly their willingness to engage in rule-breaking. Effects from decisive leadership are weak and conditional on other explanatory factors. These findings provide valuable insights for theory and practice in crisis and human resource management, demonstrating that organizations have limited leverage in influencing whether their employees engage in rule-breaking behavior, which is, in the main, conditional on individual factors and the characteristics of the crisis.
Three-dimensional semi-supervised lumbar vertebrae region of interest segmentation based on MAE pre-training
Authors: Liu Yang , Chen Jian , Hai Jinjin , Qiao Kai , Qi Xin , Li Yongli , Yan Bin
Published: January 2025

Background: 

The annotation of the regions of interest (ROI) of lumbar vertebrae by radiologists for bone density assessment is a tedious and time-intensive task. However, deep learning (DL) methods for image segmentation has the potential to substitute manual annotations which can significantly improve the efficiency of clinical diagnostics.

Objective: 

The paper proposes a semi-supervised three-dimensional (3D) segmentation method for the ROI of lumbar vertebrae by integrating the tube masking masked autoencoder (MAE) pre-training.

Methods: 

The paper proposes a method that modifies the masking strategy of the original MAE pre-training network. And the pre-training network is only trained by images without segmentation labels, when the training is finished, the weights will be saved for segmentation tasks. In downstream tasks, a semi-supervised approach utilizing pseudo-label generation is employed for training. This method leverages a small amount of labeled data to achieve the segmentation of ROI of the lumbar vertebrae.

Results: 

The experimental results demonstrate that under the condition of limited annotated data, the proposed network improves the dice coefficient by 5–7% and reduces the hausdorff distance by 0.2∼0.6 mm compared to using the UNetr network alone for segmentation. When compared to the conventional MAE, the tube masking MAE presented in this paper assists effectively in segmentation, resulting in a 2% increase in the dice coefficient and a 0.24 mm reduction in the hausdorff distance.

Conclusion: 

Automatic segmentation of the ROI of the lumbar vertebrae helps to shorten the time for doctors to annotate vertebrae during clinical bone density examinations. The paper employs the tube masking MAE pre-trained model to effectively extract contextual information of the 3D lumbar vertebrae, combining it with a semi-supervised network leveraging pseudo-label generation for fine-tuning, which leads to effective 3D segmentation of the lumbar vertebrae.
Examining the mechanism of disavowal and its two forms: Cynical disavowal and fetishistic disavowal
Authors: Black Jack
Published: January 2025

This paper posits the existence of two forms of disavowal: cynical and fetishistic. It explores how cynical disavowal involves maintaining a manipulative distance by obscuring the gap between belief and action, allowing the cynic to disavow their investment in an unattainable object and their knowledge of the Other’s lack. In contrast, fetishistic disavowal acknowledges both the objective reality of things and their subjective appearance to the fetishist. Unlike cynicism, fetishism does not rely on obscuring the gap between belief and action; instead, it recognizes and embraces both aspects. In doing so, this paper highlights significant differences between the manipulative distance of the cynic and the self-awareness of the fetishist. It acknowledges the role of cynicism in maintaining the limits and prohibitions within ideology and authority, through examples of banality, while also emphasizing the unique qualities of fetishistic disavowal.
Investigation of the Effect of Counseling Given to Postpartum Women with the EX-PLISSIT Model on Sexual
Authors: Üstgörül Sema , Yanıkkerem Emre , Göker Aslı
Published: January 2025

The aim of this study was to investigate the effect of counselling using the EX-PLISSIT model on sexual problems experienced by postpartum women. The study collected data from a sample of 1062 women who gave birth at a Public University Hospital in 2017, using the Arizona Sexual Experiences Scale and Golombok Rust Inventory of Sexual Satisfaction Scale. The study was conducted in two stages, with 189 women in the first stage and 150 women in the second stage. Women in the intervention group received sexual counselling based on the EX-PLISSIT model. A statistically significant difference was found in the education level of the women and the age and education level of their spouses. Pain was reported by 14.7% of women during the pre-pregnancy period, 12.0% during pregnancy, and 26.7% during the third month after delivery. A statistical difference was found between the intervention and control groups in the sub-dimension scores of the Golombok Rust Inventory of Sexual Satisfaction, including communication, satisfaction, avoidance, touch, vaginismus, and orgasm, as well as the Arizona Sexual Experiences Scale, including sexual desire, vaginal wetting/moisturizing, and satisfying orgasm. However, age, income status, marital age, marital type, marital adjustment, parity, and childbearing were not statistically significant differences between the intervention and control groups. The study found that counselling with EX-PLISSIT had a positive effect on both sexual dysfunction and the quality of sexual intercourse.
Indigenizing collaborative methods in studying human–water relations in the Syilx Okanagan Territory of British Columbia, Canada
Authors: Correia Maria , Alexis Sarah , Dulic Aleksandra
Published: January 2025

This article describes co-design and Indigenous methodologies applied in Waterways, Past, Present, and Future, a research inquiry and immersive media exhibition on human water relations carried out in the Syilx Okanagan First Nation territory of British Columbia, Canada. As a backdrop, we provide an overview of collaborative research, co-design, and Indigenous methodologies principles and then describe how these edicts were reflected in Waterway's praxis. The co-leadership of the research team, the cross-cultural interdisciplinary composition of the team, the decolonizing frame applied throughout the inquiry and design process, and the timeframe for team members to carry out personalized and collective multi-layered preparation were key ingredients in the application of Indigenous methodologies. Co-design principles observed in Waterways included prioritizing design justice and incorporating reflexivity and flexibility, iteration, and emergence in the design process. These methodological considerations can lead to more impactful co-design and cross-cultural research collaboration in Indigenous settings, which is currently a priority in Canada's ongoing reconciliation process.
NIRSA Student Referees: Exploring the Connection between Sense of Community and Positive Health and Wellbeing Outcomes
Authors: Tingle Jacob K , Jacobs Brittany L , Flint April , Warner Stacy
Published: January 2025

Despite working in complex environments, which require managing antagonistic and abusive relationships, sport referees are essential to ensure fair and safe competition. Evidence suggests officiating can positively impact wellbeing and officiating communities provide social support. Despite those positives, there remains a shortage of qualified officials, which is compounded by aging referee populations. These concerns emphasize the need to attract young people and examine wellbeing benefits resulting from involvement in officiating communities. As such, the aim of this study is to help NIRSA professionals better understand how the community or social networks made through officiating intramural sports could better support student employee wellbeing. Semistructured interviews with 44 referees aged, 18 to 23, revealed themes describing the relationship between sense of community and wellbeing. Details about the three major themes, individual wellbeing, community wellbeing, and importance of campus recreation, and seven subthemes will be discussed. Practical implications to help campus recreation professionals understand factors impacting retention, feelings of community, and student referees’ wellbeing will be presented.
Evaluating the impact of stratification on the power and cross-arm balance of randomized phase 2 clinical trials
Authors: Moseley Anna , LeBlanc Michael , Freidlin Boris , Shallis Rory M , Zeidan Amer M , Sallman David A , Erba Harry P , Little Richard F , Othus Megan
Published: January 2025

Background/aims

Randomized clinical trials often use stratification to ensure balance between arms. Analysis of primary endpoints of these trials typically uses a “stratified analysis,” in which analyses are performed separately in each subgroup defined by the stratification factors, and those separate analyses are weighted and combined. In the phase 3 setting, stratified analyses based on a small number of stratification factors can provide a small increase in power. The impact on power and type-1 error of stratification in the setting of smaller sample sizes as in randomized phase 2 trials has not been well characterized.

Methods

We performed computational studies to characterize the power and cross-arm balance of modestly sized clinical trials (less than 170 patients) with varying numbers of stratification factors (0–6), sample sizes, randomization ratios (1:1 vs 2:1), and randomization methods (dynamic balancing vs stratified block).

Results

We found that the power of unstratified analyses was minimally impacted by the number of stratification factors used in randomization. Analyses stratified by 1–3 factors maintained power over 80%, while power dropped below 80% when four or more stratification factors were used. These trends held regardless of sample size, randomization ratio, and randomization method. For a given randomization ratio and sample size, increasing the number of factors used in randomization had an adverse impact on cross-arm balance. Stratified block randomization performed worse than dynamic balancing with respect to cross-arm balance when three or more stratification factors were used.

Conclusion

Stratified analyses can decrease power in the setting of phase 2 trials when the number of patients in a stratification subgroup is small.
Scholarly Podcasting for Research Dissemination: A Scoping Review
Authors: Persohn Lindsay , Branson Stephanie
Published: January 2025

The purpose of this scoping review is to understand ways in which podcasting is used to communicate research findings and mobilize knowledge to a public audience. We address the use of podcasting as a broad research dissemination tool, as opposed to podcasting as a tool in formal education contexts. We summarize findings of individual studies, then identify themes across those studies. We offer definitions of specialized terms, as well as affordances and constraints of scholarly podcasting. We found scholarly podcasting allows a way for researchers to share research knowledge with the public, mobilizing knowledge more readily to a broader audience. We draw parallels to and outline departures from traditional publishing. We offer directions for future research, noting that podcasting holds the potential to impact public understanding of research by moving beyond the traditional forms of knowledge dissemination to cultivate a more equitable future for research.
Gendered Racial Identity, Positive Health Practices, and Mental Health Among Black Adult Women
Authors: Leath Seanna , Johnson Khrystal , Regis Dionne R. , Onuoha Alexandria C. , Butler-Barnes Sheretta
Published: January 2025

In the current study, we analyzed data from a national sample of 501 Black women (18–35 years old, M = 27) to examine the associations between gendered racial identity beliefs, the Superwoman Schema, and positive health practices on women’s stress, anxiety, and depression. Gendered racial centrality and endorsement of the Superwoman Schema was associated with poorer mental health outcomes, while positive beliefs about being a Black woman were associated with lower levels of stress, anxiety, and depression. Black women with more supportive social relationships indicated less stress, anxiety, and depression. We also considered individual-level differences and found that younger and neurodiverse and disabled Black women reported more stress, anxiety, and depression. The results highlight the multidimensionality of gendered racial identity beliefs in relation to mental health outcomes, as well as the need for more research on individual-level differences and the role of self-compassion in Black women’s experiences.
Patient Perspectives of “Failure” in Breast Reconstruction: A Systematic Review of Qualitative Literature
Authors: Hircock Caroline , Kim Patrick , Achunair Abhishek , Behroozian Tara , Gallo Lucas , Dunn Emily , Thoma Achilles
Published: January 2025

Introduction: The concept of failure in breast reconstruction can occur when negative outcomes dominate the patient experience. The primary objective of this review was to identify experiences of failure in breast reconstruction from the patient's perspective in the qualitative literature. Methods: MEDLINE, Embase, Psychinfo, Emcare, and CINAHL were searched on July 31, 2023 using terms related to breast reconstruction and qualitative research. Thematic analysis was performed on direct quotations from included studies. Confidence in the Evidence from Reviews of Qualitative (CERQual) Research was used to assess confidence of the final findings. Results: Forty-two studies were identified. The following themes were identified in breast reconstruction failure: (1) failure occurs when expectations of restoring the original breast are not met with reconstruction, (2) failure occurs when unexpected outcomes were associated with the reconstruction, and (3) healthcare providers negatively impact the experience of breast reconstruction failure through lack of transparency when educating patients on expected results and poor relational support in the post-operative period. The evidence supporting themes 1-3 scored high confidence with CERQual. Conclusion: Breast reconstruction failure from the patient perspective arises from the limitations and adverse outcomes of the surgery. They may also arise even when the procedure was deemed “successful” from the surgeon's perspective. Dissatisfaction with result is increased by procedural complications. Healthcare providers can aggravate the perception of failure through inadequate patient education. Incorporating these perceptions of failure into discussions with patients can aid in their decision making.
Clinical and Radiological Outcomes After Lateral Meniscal Allograft Transplantation Through a Medial Arthrotomy: A Minimum 4-Year Follow-up
Authors: Choi Nam-Hong , Yang Bong-Seok , Lee Dong-Min , Kim Dong-Kyun , Victoroff Brian N.
Published: January 2025

Background:

Previous studies have demonstrated that lateral meniscal allograft transplantation (MAT) through medial arthrotomy showed less extrusion than that of the lateral arthrotomy. However, there is a paucity of literature reporting clinical and radiological outcomes after lateral MAT through the medial arthrotomy.

Hypothesis:

Lateral MAT through a medial arthrotomy would show significantly improved clinical scores and minimal joint space narrowing compared with preoperative status.

Study Design:

Case series; Level of evidence, 4.

Methods:

Between 2001 and 2019, a retrospective chart review was conducted for all patients who underwent lateral MAT using the bony bridge technique through medial arthrotomy. Inclusion criteria were patients who underwent lateral MAT after subtotal or total meniscectomy of the lateral meniscus. A total of 27 patients who were not followed up for >4 years or had follow-up magnetic resonance imaging after surgery were excluded. At final follow-up, Lysholm scores and Tegner activity scale scores were collected. Graft extrusion, trough angle, and position of the bony bridge were measured by magnetic resonance imaging at 6 months after MAT. Joint space width (JSW) of the lateral compartment on Rosenberg view was measured and compared preoperatively and at follow-up.

Results:

A total of 28 patients were included in this study. Their mean age was 29.8 years (range, 15-48 years) with a mean follow-up of 11.4 years. Preoperative Lysholm scores and Tegner activity scale scores (66.5 ± 16.6 and 3.1 ± 1.9, respectively) significantly improved at follow-up (84.8 ± 11.1 [ P < .001] and 4.4 ± 1.5 [ P = .008], respectively). The JSW decreased from 6.2 ± 1.6 mm to 5.7 ± 1.4 mm ( P = .014). Extrusion was 2.2 ± 1.5 mm, and trough angle was 1.5°± 8.9°. The bony bridge was positioned at 43.9% ± 4.3% from the lateral edge on the entire tibial plateau. Nine patients (32.1%) underwent subsequent procedures. Partial meniscectomies were performed in 2 patients, meniscal repairs in 2, manipulation under anesthesia in 1, and lateral capsular plication in 1. Three patients who underwent total meniscectomy or revision surgery were regarded as having a failure; therefore, 89.3% grafts survived.

Conclusion:

Lateral MAT through the medial arthrotomy demonstrated satisfactory clinical and radiological outcomes at long-term follow-up.
A Pilot Case-Study of Using Instructional and Demonstration Videos as a Supplementary Tool for Learning in an Exercise Science Course at a Minority-Serving Institution
Authors: Nastvogel LaShawn D.
Published: January 2025

Lecture recording is a practice several programs and courses (virtual and face-to-face) are employed to allow for students to have access to live self-paced lectures, to provide an additional study tool, and at times, recordings are provided as a source of engagement. Universal software programs such as Echo 360 allow instructors to record and monitor student engagement with video content such as view time. Research has explored student use of lecture recordings; however, this project explores how accessing the videos influenced the student aside from gaining content knowledge. Instructional and demonstration videos were included as supplemental materials within content-based modules on the learning management platform at the institution. Seventeen students were enrolled in the upper-level undergraduate exercise science course and had immediate access to the recordings. Situational motivation was analyzed and reported. On average, at mid-term and the final point in the semester, students were extrinsically motivated when choosing to watch the recording(s), however, positive shifts towards intrinsic motivation were noticed along the continuum of motivation. The significance of the change in motivation was not explored. This pilot case study recommends the addition of active assignments with supplementary materials such as relevant video instructions and demonstrations to guide students in understanding and applying hands-on concepts in upper-level exercise science programming courses to mentally prepare students for undergraduate internships in the field.
Weightbearing in Select Geriatric Ankle Fractures Following Open Reduction Internal Fixation: Short Scientific Report
Authors: Coscia Atticus , Jandzinski Michal , Talusan Paul , Ahn Jaimo
Published: January 2025

Background:

Geriatric ankle fractures are increasingly common. Previous work has suggested that early weightbearing following ankle fracture fixation is safe in nongeriatric patients. However, limited data is available regarding the safety of immediate weightbearing following fixation of geriatric ankle fractures using standard open reduction internal fixation techniques.

Methods:

Forty-four patients aged 65 years or older treated for rotational ankle fractures were propensity matched, with 22 patients following a nonweightbearing (NWB) protocol and 22 were allowed to weightbear immediately (WBAT) in a controlled ankle motion boot at all times. Primary outcomes included hardware failure and postoperative complications. Group differences in continuous variables were analyzed via Student t test whereas Fisher exact tests were used to analyze the differences in categorical variables. Complication-free survival and hardware failure–free survival were compared using the log-rank (Mantel-Cox) test.

Results:

There were no hardware failures in the WBAT group and 1 hardware failure in the NWB group; the difference was not statistically significant. There was no difference in incidence of postoperative complications, rate of hardware failure, or PROM scores.

Conclusion:

In this preliminary study group, we found that immediate weightbearing following fixation of geriatric ankle fractures was not associated with increased hardware failure or postoperative complications.

Level of Evidence:

Level IV, retrospective cohort.