bluuebunny/crossref_metadata_2025 huggingface dataset:
HLA-G 3′ untranslated region variants +3187G/G, +3196G/G and +3035T define diametrical clinical status and disease outcome in epithelial ovarian cancer
Authors: Schwich Esther , Rebmann Vera , Michita Rafael Tomoya , Rohn Hana , Voncken Jan Willem , Horn Peter A. , Kimmig Rainer , Kasimir-Bauer Sabine , Buderath Paul
Published: April 2019

Expression of the non-classical human leukocyte antigen-G (HLA-G) promotes cancer progression in various malignancies including epithelial ovarian cancer (EOC). As single nucleotide polymorphisms (SNPs) in the HLA-G 3′ untranslated region (UTR) regulate HLA-G expression, we investigated HLA-G 3′UTR haplotypes arranged by SNPs in healthy controls (n = 75) and primary EOC patients (n = 79) and determined soluble HLA-G (sHLA-G) levels. Results were related to the clinical status and outcome. Although haplotype frequencies were similar in patients and controls, (i) sHLA-G levels were increased in EOC independent of the haplotype, (ii) homozygosity for UTR-1 or UTR-2 genotypes were significantly associated with metastases formation and presence of circulating tumor cells before therapy, whereas (iii) the UTR-5 and UTR-7 haplotypes were significantly associated with a beneficial clinical outcome regarding negative nodal status, early FIGO staging, and improved overall survival. Lastly, (iv) the ambivalent impact on clinical EOC aspects could be deduced to specific SNPs in the HLA-G 3′UTR: +3187G, +3196G and +3035T alleles. Our results give evidence that even if the genetic background of the HLA-G 3′UTR is identical between patients and controls, certain SNPs have the potential to contribute to diametrical clinical status/outcome in EOC.
Effects of hyperthyroidism in the development of the appendicular skeleton and muscles of zebrafish, with notes on evolutionary developmental pathology (Evo-Devo-Path)
Authors: Shkil Fedor , Siomava Natalia , Voronezhskaya Elena , Diogo Rui
Published: April 2019

The hypothalamus-pituitary-thyroid (HPT) axis plays a crucial role in the metabolism, homeostasis, somatic growth and development of teleostean fishes. Thyroid hormones regulate essential biological functions such as growth and development, regulation of stress, energy expenditure, tissue compound, and psychological processes. Teleost thyroid follicles produce the same thyroid hormones as in other vertebrates: thyroxin (T4) and triiodothyronine (T3), making the zebrafish a very useful model to study hypo- and hyperthyroidism in other vertebrate taxa, including humans. Here we investigate morphological changes in T3 hyperthyroid cases in the zebrafish to better understand malformations provoked by alterations of T3 levels. In particular, we describe musculoskeletal abnormalities during the development of the zebrafish appendicular skeleton and muscles, compare our observations with those recently done by us on the normal developmental of the zebrafish, and discuss these comparisons within the context of evolutionary developmental pathology (Evo-Devo-Path), including human pathologies.
Fatal traumatic brain injuries during 13 years of successive alcohol tax increases in Finland – a nationwide population-based registry study
Authors: Posti Jussi P. , Sankinen Matti , Sipilä Jussi O. T. , Ruuskanen Jori O. , Rinne Jaakko , Rautava Päivi , Kytö Ville
Published: April 2019

We sought to investigate how increases in alcohol taxation and changes in alcohol consumption were associated with the incidence rate of fatal traumatic brain injuries (TBI) in Finland during the years 2004–2016. Nationwide, mandatory cause of death database covering all deaths in Finland was searched for all deaths related to TBIs (ICD-10: S06.X) in persons ≥16 years of age during 2004–2016. Study period included 28,657,870 person-years and 325,514 deaths of which 12,110 were TBI-related. Occurrence rates were standardized to European 2013 standard population. Data for alcohol consumption were obtained from the National Institute for Health and Welfare and for alcohol taxation from Ministry of Finance, Finland. Standardized incidence rate of TBI-related death was 22.0 (95% CI 21.61–22.38) per 100,000 person-years. Overall alcohol consumption decreased on average by 1.2% annually. Concurrently, the overall incidence rate of fatal TBIs decreased by 4.1% annually (by 4.3% in men and 2.4% in women). There was an association between overall alcohol consumption and TBI-related mortality rate (p < 0.001). Tax-rate increases of all beverage types were associated with decreased incidence rate of TBI-related death in men (p < 0.001), in women (p < 0.036) and overall (p < 0.001). In this population-based study, we report that during 13 years of successive alcohol tax increases, overall alcohol consumption has decreased in parallel with a reduction in the incidence rate of fatal TBIs in Finland.
The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/β-catenin signalling in the developing cerebellum via Hoxb5
Authors: Abdelhamed Zakia A. , Abdelmottaleb Dina I. , El-Asrag Mohammed E. , Natarajan Subaashini , Wheway Gabrielle , Inglehearn Chris F. , Toomes Carmel , Johnson Colin A.
Published: April 2019

Primary cilia defects result in a group of related pleiotropic malformation syndromes known as ciliopathies, often characterised by cerebellar developmental and foliation defects. Here, we describe the cerebellar anatomical and signalling defects in theTmem67tm1(Dgen)/Hknockout mouse. At mid-gestation,Tmem67mutant cerebella were hypoplastic and had aberrantly high canonical Wnt/β-catenin signalling, proliferation and apoptosis. Later in development, mutant cerebellar hemispheres had severe foliation defects and inferior lobe malformation, characterized by immature Purkinje cells (PCs). Early postnatalTmem67mutant cerebellum had disrupted ciliogenesis and reduced responsiveness to Shh signalling. Transcriptome profiling ofTmem67mutant cerebella identified ectopic increased expression of homeobox-type transcription factors (Hoxa5,Hoxa4,Hoxb5andHoxd3), normally required for early rostral hindbrain patterning. HOXB5 protein levels were increased in the inferior lobe, and increased canonical Wnt signalling, following loss of TMEM67, was dependent on HOXB5. HOXB5 occupancy at the β-catenin promoter was significantly increased by activation of canonical Wnt signalling inTmem67−/−mutant cerebellar neurones, suggesting that increased canonical Wnt signalling following mutation or loss of TMEM67 was directly dependent on HOXB5. Our results link dysregulated expression of Hox group genes with ciliary Wnt signalling defects in the developing cerebellum, providing new mechanistic insights into ciliopathy cerebellar hypoplasia phenotypes.
Ancient human mitochondrial genomes from Bronze Age Bulgaria: new insights into the genetic history of Thracians
Authors: Modi Alessandra , Nesheva Desislava , Sarno Stefania , Vai Stefania , Karachanak-Yankova Sena , Luiselli Donata , Pilli Elena , Lari Martina , Vergata Chiara , Yordanov Yordan , Dimitrova Diana , Kalcev Petar , Staneva Rada , Antonova Olga , Hadjidekova Savina , Galabov Angel , Toncheva Draga , Caramelli David
Published: April 2019

One of the best documented Indo-European civilizations that inhabited Bulgaria is the Thracians, who lasted for more than five millennia and whose origin and relationships with other past and present-day populations are debated among researchers. Here we report 25 new complete mitochondrial genomes of ancient individuals coming from three necropolises located in different regions of Bulgaria – Shekerdja mogila, Gabrova mogila and Bereketska mogila – dated to II-III millennium BC. The identified mtDNA haplogroup composition reflects the mitochondrial variability of Western Eurasia. In particular, within the ancient Eurasian genetic landscape, Thracians locate in an intermediate position between Early Neolithic farmers and Late Neolithic-Bronze Age steppe pastoralists, supporting the scenario that the Balkan region has been a link between Eastern Europe and the Mediterranean since the prehistoric time. Spatial Principal Component Analysis (sPCA) performed on Thracian and modern mtDNA sequences, confirms the pattern highlighted on ancient populations, overall indicating that the maternal gene pool of Thracians reflects their central geographical position at the gateway of Europe.
Machine Learning Approach to find the relation between Endometriosis, benign breast disease, cystitis and non-toxic goiter
Authors: Lee Jung Hun , Kwon Seon-Young , Chang Jiho , Yuk Jin-Sung
Published: April 2019

The exact mechanism of endometriosis is unknown. The recommendation system (RS) based on item similarities of machine learning has never been applied to the relationship between diseases. The study aim was to identify diseases associated with endometriosis by applying RS based on item similarities to insurance data in South Korea. Women aged 15 to 45 years extracted from the Korean Health Insurance Review & Assessment Service National Inpatient Sample (HIRA-NIS) 2009–2015. We used the RS model to extract diseases that were correlated with an endometriosis diagnosis. Among women aged 15 to 45 years, endometriosis was defined as a diagnostic code of N80.x and a concurrent treatment code. A control group was defined as women who did not have the N80.x code. Benign breast diseases, cystitis, and non-toxic goitre were extracted by the RS. A total of 1,730,562 women were selected as the control group, and 11,273 women were selected as the endometriosis group. In logistic regression analysis adjusted for age per 5 years, data year, and socioeconomic status, benign neoplasm of breast (odds ratio (OR): 2.58; 95% confidence interval (CI): 1.90–3.50), other cystitis (OR: 2.63; 95% CI: 1.56–4.44), and non-toxic single thyroid nodule (OR: 1.62; 95% CI: 1.14–2.32) were statistically significant. Endometriosis was associated with benign breast disease, cystitis, and non-toxic goitre.
Metallothionein Genes are Highly Expressed in Malignant Astrocytomas and Associated with Patient Survival
Authors: Masiulionytė Bernadeta , Valiulytė Indrė , Tamašauskas Arimantas , Skiriutė Daina
Published: April 2019

Gliomas are heterogeneous, primary brain tumours that originate from glial cells. The main type of gliomas is astrocytomas. There are four grades (I-IV) of astrocytoma malignancy. Astrocytoma grade IV known as glioblastoma multiforme (GBM) is the most common and aggressive type of astrocytic gliomas. Metallothioneins (MT) are low molecular weight, cysteine rich proteins encoded by a family of metallothionein (MT) genes. MT genes play a crucial role in carcinogenesis of diverse malignancies. We proposed MT genes as prognostic markers for malignant astrocytoma. MT1A, MT1E, MT1X, MT2, MT3 gene expression was elevated in grade IV astrocytomas (glioblastomas) as compared to astrocytomas grade I-III. Statistically significant differences were reached for MT1A and MT2 genes (Mann-Whitney test, p < 0.05). High MT1A, MT1X, MT2, MT3 genes expression was associated with shorter patient survival (Log-rank test, p < 0.05). MT1A gene promoter methylation was decreased in glioblastoma (57.6%) while the gene was highly methylated in grade II-III astrocytoma (from 66.7% to 83.3%) and associated with better patient survival (p < 0.05). MT1A gene methylation showed a trend of being associated with higher mRNA expression level in astrocytomas. Increased MT genes expression in grade IV astrocytomas as compared to I-III grade astrocytomas could be associated with malignant tumour behaviour and progression.
The Influence of Energy Depletion by Metformin or Hypocaloric Diet on Thyroid Iodine Uptake in Healthy Volunteers: a Randomized Trial
Authors: Sloot Yvette J. E. , Janssen Marcel J. R. , van Herwaarden Antonius E. , Peeters Robin P. , Netea-Maier Romana T. , Smit Johannes W. A.
Published: April 2019

Sufficient thyroid iodine uptake is needed to ensure effective radioactive iodine (RAI) treatment, which is mediated by the sodium-iodide symporter (NIS). Activation of AMP-activated-protein-kinase (AMPK), leads to decreased NIS expression and thyroid iodine uptake in in vitro and animal models. Clinically relevant conditions that lead to AMPK activation include metformin use and hypocaloric conditions. Here, we aim to assess the effects of metformin and hypocaloric diet on thyroid iodine uptake in healthy volunteers. Healthy male volunteers were included and randomized. Group 1 (n = 8) received metformin, group 2 (n = 7) followed a hypocaloric diet (1500 kcal/day), superposed on a moderate iodine restriction diet; Baseline measurements included thyroid iodine-123 (I-123) uptake and TSH, fT4, T3 and rT3 levels. After two weeks, thyroid function and I-123 uptake measurements were repeated. Baseline characteristics were similar between groups. Levels of TSH and fT4 were similar after each intervention. T3 decreased after hypocaloric diet and metformin (−0.2 ± 0.19 nmol/L, p = 0.0327; respectively −0.13 ± 0.13 nmol/L, p = 0.0282), resulting in decreased T3/rT3 ratios. There was no significant difference in thyroid I-123 uptake after each intervention. In conclusion, metformin treatment and hypocaloric diet resulted in a significant decrease in T3 levels and T3/rT3 ratios in healthy volunteers, without significant effects on thyroid iodine uptake. We found no indications that metformin or hypocaloric diet will have clinically relevant effects on RAI uptake.
Food Income and the Evolution of Forager Mobility
Authors: Gallagher Elizabeth , Shennan Stephen , Thomas Mark G.
Published: April 2019

Forager mobility tends to be high, although ethnographic studies indicate ecological factors such as resource abundance and reliability, population density and effective temperature influence the cost-to-benefit assessment of movement decisions. We investigate the evolution of mobility using an agent-based and spatially explicit cultural evolutionary model that considers the feedback between foragers and their environment. We introduce Outcomes Clustering, an approach to categorizing simulated system states arising from complex stochastic processes shaped by multiple interacting parameters. We find that decreased mobility evolves under conditions of high resource replenishment and low resource depletion, with a concomitant trend of increased population density and, counter-intuitively, decreased food incomes. Conversely, increased mobility co-occurs with lower population densities and higher food incomes. We replicate the well-known relationships between mobility, population density, and resource quality, while predicting reduced food income, and consequently the reduction in health status observed in early sedentary populations without the need to invoke factors such as reduced diet quality or increased pathogen loads.
In situ construction of metal–organic framework (MOF) UiO-66 film on Parylene-patterned resonant microcantilever for trace organophosphorus molecules detection
Authors: Cai Shengran , Li Wei , Xu Pengcheng , Xia Xiaoyuan , Yu Haitao , Zhang Sen , Li Xinxin
Published: April 2019

UiO-66 film is directly grown on the sensing area of a resonant microcantilever for toxic organophosphorus molecules detection.
Activation of CO2 at the electrode–electrolyte interface by a co-adsorbed cation and an electric field
Authors: Chernyshova Irina V. , Ponnurangam Sathish
Published: April 2019

Electric polarization by the local microenvironment strongly affects the CO2 activation at the electrode–electrolyte interface.
Effect of the surface curvature on amyloid-β peptide adsorption for graphene
Authors: Yin Xiuhua , Li Baoyu , Liu Shengtang , Gu Zonglin , Zhou Bo , Yang Zaixing
Published: April 2019

The adsorbing capacity of graphene's surface varies significantly depending on its curvature, namely, the surface with negative curvature has a higher probability to adsorb the Aβ than the one with positive curvature.
Flexible hybrid structure piezoelectric nanogenerator based on ZnO nanorod/PVDF nanofibers with improved output
Authors: Fakhri Parisa , Amini Babak , Bagherzadeh Roohollah , Kashfi Mohammad , Latifi Masoud , Yavari Neda , Asadi Kani Soodeh , Kong Lingxue
Published: April 2019

A novel hybrid piezoelectric structure based on electrospun PVDF NFs and vertically grown ZnO nanorods is presented as a promising nanogenerator to convert mechanical movement more efficiently into electricity for practical applications.
A self-powered triboelectric nanosensor for detecting the corrosion state of magnesium treated by micro-arc oxidation
Authors: Zhai Yong-Mei , Li Wei , Chen Min-Fang , Li Yan-Kun , Wang Qi , Wang Yan-Song
Published: April 2019

Triboelectric nanogenerators prepared by micro-arc-oxidation-treated magnesium were used as a sensor to detect the corrosion state of it in return.
Facet-dependent photocatalytic hydrogen production of metal–organic framework NH2-MIL-125(Ti)
Authors: Guo Fan , Guo Jin-Han , Wang Peng , Kang Yan-Shang , Liu Yi , Zhao Jing , Sun Wei-Yin
Published: April 2019

Facet-dependent photocatalytic hydrogen generation over MOF NH2-MIL-125(Ti) under visible light was investigated, both experimentally and theoretically.
Flow-assisted droplet assembly in a 3D microfluidic channel
Authors: Ge Zhouyang , Tammisola Outi , Brandt Luca
Published: April 2019

Systematic numerical simulations reveal the hydrodynamic mechanism of droplet interactions, guiding the microfluidic design for production of future photonic materials.
A review of nanostructured non-titania photocatalysts and hole scavenging agents for CO2 photoreduction processes
Authors: Tan Jeannie Z. Y. , Maroto-Valer M. Mercedes
Published: April 2019

Non-titania photocatalysts, including metal sulphides, oxides, oxynitrides and nitrides, have been deployed as the photocatalyst for CO2 photoreduction since last century. The nanostructured non-titania photocatalysts and the introduction of hole scavenging agents into the CO2 photoreduction system have revealed some key characteristics to stimulate the conversion of CO2 to hydrocarbons.
Composite K2Mo4O13/α-MoO3 nanorods: sonochemical preparation and applications for advanced Li+/Na+ pseudocapacitance
Authors: Hu Mingxiang , Jing Huijuan , Li Tao , Wang Jiahao , Yang Huaming , Lv Ruitao , Chen Deliang
Published: April 2019

A novel nanocomposite of K2Mo4O13/MoO3 with a uniformly rod-like morphology is fabricated via a sonochemical method. Benefiting from its open framework, the as-synthesized sample exhibits obvious pseudocapacitive behaviors both in lithium and sodium ion batteries.
A facile room temperature solution synthesis of SnO2quantum dots for perovskite solar cells
Authors: Liu Hongri , Chen Zhiliang , Wang Haibing , Ye Feihong , Ma Junjie , Zheng Xiaolu , Gui Pengbin , Xiong Liangbin , Wen Jian , Fang Guojia
Published: April 2019

We introduce a facile route to synthesize SnO2quantum dots colloidal solution at room temperature and superior homogeneous ETL is obtained by spin coating of the QDs colloidal solution with post-deposition annealing.
Development of fast-response turn-on phosphorescent probes for biothiols based on ruthenium(ii) complexes
Authors: Zheng Ze-Bao , Cui Ji-Chun , Han Yin-Feng , Ge Yan-Qing , Zuo Jian , Hao Wen-Xin
Published: April 2019

A novel 2,4-dinitrobenzenesulfonyl appended ruthenium(ii) complex acting as a fast-response “turn on” phosphorescent sensor for biothiols was successfully demonstrated.
Preparation of a POSS-hybridized molecularly imprinted monolith for the analysis of baicalin and its analogues in a microwave-assisted extract from Scutellaria baicalensis by means of on-line SPME-HPLC and off-line LC-MS/MS
Authors: Bi Xiaodong , Tian Wei , Wang Xiang , Cao Wenli , Gao Le , Fan Shuaishuai , Wang Yingchun , Wang Meng , Niu Liying
Published: April 2019

Molecularly imprinted polymers (MIPs) have been attracting increasing attention and used in various applications.
Exploring reaction dynamics in lithium–sulfur batteries by time-resolved operando sulfur K-edge X-ray absorption spectroscopy
Authors: Zhao Enyue , Wang Junyang , Li Feng , Jiang Zheng , Yang Xiao-Qing , Wang Fangwei , Li Hong , Yu Xiqian
Published: April 2019

The multistep kinetic-determining conversion process of a sulfur electrode is directly revealed through time-resolved operando X-ray absorption spectroscopy.
Efficient electrohydrogenation of N2 to NH3 by oxidized carbon nanotubes under ambient conditions
Authors: Zhao Jinxiu , Wang Bo , Zhou Qiang , Wang Huanbo , Li Xianghong , Chen Hongyu , Wei Qin , Wu Dan , Luo Yonglan , You Jinmao , Gong Feng (Frank) , Sun Xuping
Published: April 2019

As a metal-free electrocatalyst for the N2 reduction reaction, oxidized carbon nanotubes attain NH3 yield of 32.33 mg h−1 mgcat.−1 and faradaic efficiency of 12.50%.
A lab-on-a-molecule with an enhanced fluorescent readout on detection of three chemical species
Authors: Scerri Glenn J. , Spiteri Jake C. , Mallia Carl J. , Magri David C.
Published: April 2019

The first naphthalimide-based three-input AND logic gate detects a congregation of three cations in aqueous methanol with a 25-fold enhanced fluorescence.
5′-Morpholino modification of the sense strand of an siRNA makes it a more effective passenger
Authors: Kumar Pawan , Parmar Rubina G. , Brown Christopher R. , Willoughby Jennifer L. S. , Foster Donald J. , Babu I. Ramesh , Schofield Sally , Jadhav Vasant , Charisse Klaus , Nair Jayaprakash K. , Rajeev Kallanthottathil G. , Maier Martin A. , Egli Martin , Manoharan Muthiah
Published: April 2019

Blocking 5′-phosphorylation of the sense strand favours selective loading of the antisense strand into RISC complex.
Head to tail cyclisation of cell-penetrating peptides: impact on GAG-dependent internalisation and direct translocation
Authors: Amoura Mehdi , Illien Françoise , Joliot Alain , Guitot Karine , Offer John , Sagan Sandrine , Burlina Fabienne
Published: April 2019

Small cationic lipidated cyclic cell-penetrating peptides enter efficiently by GAG-dependent endocytosis, expanding the macrocycle favours direct translocation.
Squaramide-decorated covalent organic framework as a new platform for biomimetic hydrogen-bonding organocatalysis
Authors: Li Xia , Wang Zhifang , Sun Jiaxing , Gao Jia , Zhao Yu , Cheng Peng , Aguila Briana , Ma Shengqian , Chen Yao , Zhang Zhenjie
Published: April 2019

The first squaramide-decorated covalent organic framework has been successfully constructed, which exhibited excellent performance in biomimetic hydrogen-bonding organocatalysis.
Light-activated “cycle-reversible intramolecular charge transfer” fluorescent probe: monitoring of pHi trace change induced by UV light in programmed cell death
Authors: Jiang Tao , Wang Xin , Wang Ge , Wang Yafu , Wang Kui , Xuan Xiaopeng , Chen Changpo , Jiang Kai , Zhang Hua
Published: April 2019

A light-activated fluorescent probe shows cycle-reversible intramolecular charge transfer for different intracellular pH under the synergistic effect of protonation–deprotonation.
Pre-nucleation aggregation based on solvent microheterogeneity
Authors: Jones Christopher D. , Walker Martin , Xiao Yitian , Edkins Katharina
Published: April 2019

The microheterogeneous region of aqueous acetonitrile leads to preferred localisation and aggregation of caffeine and theophylline on the interface.
A synthetic approach to chrysophaentin F
Authors: Vendeville Jean-Baptiste , Matters Rebecca F. , Chen Anqi , Light Mark E. , Tizzard Graham J. , Chai Christina L. L. , Harrowven David C.
Published: April 2019

A synthetic approach to chrysophaentin F is described featuring an array of metal catalysed coupling reactions (Cu, Ni, Pd, W, Mo).
Self-assembly of photochromic diarylethene–peptide conjugates stabilized by β-sheet formation at the liquid/graphite interface
Authors: Nishitani Nobuhiko , Hirose Takashi , Matsuda Kenji
Published: April 2019

Two-dimensional (2-D) self-assembly of diarylethene (DAE)–peptide conjugates at the octanoic acid/graphite interface was investigated by scanning tunnelling microscopy (STM) and strong stabilization effect of β-sheet formation was revealed.
Programming a split G-quadruplex in a DNA nanocage and its microRNA imaging in live cells
Authors: Yu Yanyan , Zhou Yao , Zhu Min , Liu Mingkai , Zhu Hongyan , Chen Yong , Su Gaoxing , Chen Wei , Peng Huaping
Published: April 2019

Programing target-responsive devices by incorporating a split G4 motif in a DNA nanocage and its miRNA imaging in living cells.
N-CND modified NH2-UiO-66 for photocatalytic CO2 conversion under visible light by a photo-induced electron transfer process
Authors: Chen Liyong , Yu Fengyang , Shen Xiaoshuang , Duan Chunying
Published: April 2019

A N-CNDs/NH2-UiO-66 composite exhibits enhanced photocatalytic activity for CO2 conversion under visible light irradiation. This is attributed to a photo-induced electron transfer process from the light absorption antenna of the N-CNDs to the NH2-UiO-66 photocatalyst.
Spontaneous shape and phase control of colloidal ZnSe nanocrystals by tailoring Se precursor reactivity
Authors: Chen Wei , Karton Amir , Hussian Tanveer , Javaid Shaghraf , Wang Fei , Pang Yingping , Jia Guohua
Published: April 2019

A novel synthetic method of shape and phase control of ZnSe nanocrystals by tailoring Se precursor reactivity is reported.
Reversible temperature-induced polymorphic phase transitions of [Y(OAr)3] and [Ce(OAr)3] (Ar = 2,6-tBu2-4-MeC6H2): interconversions between pyramidal and planar geometries
Authors: Haddow Mairi F. , Newland Robert J. , Tegner Bengt E. , Mansell Stephen M.
Published: April 2019

Exploring the balance of energetics between planar and pyramidal forms of [Y(O-2,6-tBu2-4-MePh)3] and related complexes.
Electric field control of resistive switching and magnetization in epitaxial LaBaCo2O5+δ thin films
Authors: Shaibo Jamal , Yang Rui , Wang Zhe , Huang He-Ming , Xiong Jue , Guo Xin
Published: April 2019

Resistive switching and magnetization in epitaxial LaBaCo2O5+δ films can be controlled through an external electrical field, and the switching is related to the tuning of oxygen vacancies and the Co–O–Co bond length.
Dynamics of electronically excited states in the eumelanin building block 5,6-dihydroxyindole
Authors: Crane Stuart W. , Ghafur Omair , Cowie Thomas Y. , Lindsay Anita G. , Thompson James O. F. , Greenwood Jason B. , Bebbington Magnus W. P. , Townsend Dave
Published: April 2019

Laser-based thermal desorption facilitates the first gas-phase study of ultrafast non-adiabatic dynamics operating in 5,6-dihydroxyinole following ultraviolet excitation.
The synthesis and photophysical properties of tris-coumarins
Authors: Kielesiński Łukasz , Morawski Olaf W. , Sobolewski Andrzej L. , Gryko Daniel T.
Published: April 2019

In head-to-tail linked linear tris-coumarins the photophysical properties are controlled by their relative conformation. This depends on the hydrogen bonding interactions of their linkers.
Preparation of core–shell PW12@TiO2 microspheres and oxidative desulfurization performance
Authors: Gao Hongcheng , Wu Xiaonan , Sun Dongmei , Niu Guiling , Guan Jianyi , Meng Xiangfu , Liu Changzhan , Xia Wandong , Song Xiaojing
Published: April 2019

Polyoxometalate-based heterogeneous catalyst with core–shell structure.
Synthesis, physico-chemical characterization and structure of the elusive hydroxylammonium lead iodide perovskite NH3OHPbI3
Authors: D'Annibale Andrea , Panetta Riccardo , Tarquini Ombretta , Colapietro Marcello , Quaranta Simone , Cassetta Alberto , Barba Luisa , Chita Giuseppe , Latini Alessandro
Published: April 2019

The elusive hydroxylammonium lead iodide NH3OHPbI3 has been successfully synthesized and characterized for the first time.
A bifunctional dermaseptin–thanatin dipeptide functionalizes the crop surface for sustainable pest management
Authors: Schwinges Patrick , Pariyar Shyam , Jakob Felix , Rahimi Mehran , Apitius Lina , Hunsche Mauricio , Schmitt Lutz , Noga Georg , Langenbach Caspar , Schwaneberg Ulrich , Conrath Uwe
Published: April 2019

A bifunctional dipeptide can help to reduce pesticide use while preserving crop productivity.
Determination of methylmercury using liquid chromatography – photochemical vapour generation – atomic fluorescence spectroscopy (LC-PVG-AFS): a simple, green analytical method
Authors: Lancaster Shaun , Brombach Christoph-Cornelius , Corns W , Feldmann Jorg , Krupp Eva
Published: April 2019

Reliable, fast and cost efficient mercury analysis is paramount to assess Hg levels in a huge variety of matrices, from soil and water to a variety of foodstuffs. In this...
Zircon water content: reference material development and simultaneous measurement of oxygen isotopes by SIMS
Authors: Xia Xiao-Ping , Cui Ze-Xian , Li Wancai , Zhang Wan-Feng , Yang Qing , Hui Hejiu , Lai Chun-Kit
Published: April 2019

Zircon water content is an important physicochemical parameter for many geological processes, yet its measurement by the secondary ion mass spectrometry (SIMS) technique is hampered by the lack of suitable reference materials and high water background, especially if large-geometry (LG)-SIMS is used.
Nanothin film conductivity measurements reveal interfacial influence on ion transport in polymer electrolytes
Authors: Dong Ban Xuan , Bennington Peter , Kambe Yu , Sharon Daniel , Dolejsi Moshe , Strzalka Joseph , Burnett Veronica F. , Nealey Paul F. , Patel Shrayesh N.
Published: April 2019

Nanoscale interfacial zone limits ion transport properties of polymer electrolytes.
Spectroscopic properties of GdxLa1−xAlO3nanocrystals doped with Pr3+ions
Authors: Lemański K. , Bondzior B. , Szymański D. , Dereń P. J.
Published: April 2019

The spectroscopic and structural properties of GdxLa1−xAlO3nanocrystals doped with praseodymium(iii) ions have been investigated.
Strong ion pair charge transfer interaction of 1,8-naphthalimide–bipyridinium conjugates with basic anions – towards the development of a new type of turn-on fluorescent anion sensors
Authors: Szakács Zoltán , Bojtár Márton , Hessz Dóra , Rousseva Sylvia , Bitter István , Drahos László , Hilbers Michiel , Zhang Hong , Kállay Mihály , Kubinyi Miklós
Published: April 2019

Fluoride, acetate and benzoate anions reduce naphthalimide–viologen dyads into radicals, which is indicated by a strong fluorescence enhancement.
Novel ferrocene-labeled propargyl amines via CuI multicomponent amination/alkynylation
Authors: Srivastava Suman
Published: April 2019

An efficient synthesis of ferrocene-tagged propargyl amine derivatives via one-pot three-component domino amination/alkynylation in water is reported.
Determination of the DNA binding properties of a novel PARP inhibitor MK-4827 with calf-thymus DNA by molecular simulations and detailed spectroscopic investigations
Authors: Yang Hongqin , Zeng Qingle , He Ze , Wu Di , Li Hui
Published: April 2019

The binding interaction of niraparib (MK-4827), a poly(ADP-ribose) polymerase inhibitor, with calf thymus deoxyribonucleic acid (ctDNA) has been explored by various theoretical and experimental techniques.
Amplification-free SERS analysis of DNA mutation in cancer cells with single-base sensitivity
Authors: Wu Lei , Garrido-Maestu Alejandro , Guerreiro Joana R. L. , Carvalho Sandra , Abalde-Cela Sara , Prado Marta , Diéguez Lorena
Published: April 2019

An amplification-free SERS chip for cellular DNA mutation analysis has been developed.
Selective and fast plasmon-assisted photo-heating of nanomagnets
Authors: Pancaldi Matteo , Leo Naëmi , Vavassori Paolo
Published: April 2019

Hybrid plasmonic-magnetic elements facilitate contactless, fast, spatially-selective, and sublattice-specific control of temperature in functional magnetic metamaterials via optical degrees of freedom.
Stabilizing a high-voltage LiNi0.5Mn1.5O4 cathode towards all solid state batteries: a Li–Al–Ti–P–O solid electrolyte nano-shell with a host material
Authors: Li Li , Zhao Rui , Xu Tinghua , Wang Dandan , Pan Du , Zhang Kun , Yu Caiyan , Lu Xia , He Guanjie , Bai Ying
Published: April 2019

A lithium ion conducting modification shell is introduced onto the cathode surface, which realizes excellent kinetic characteristics.
Achiral amino acid glycine acts as an origin of homochirality in asymmetric autocatalysis
Authors: Matsumoto Arimasa , Ozaki Hanae , Tsuchiya Sumeru , Asahi Toru , Lahav Meir , Kawasaki Tsuneomi , Soai Kenso
Published: April 2019

Achiral glycine acts as the origin of chirality in conjunction with asymmetric autocatalysis to afford highly enantioenriched compound.
Synthesis of glycocluster-containing conjugates for a vaccine against cholera
Authors: Pfister Hélène B. , Kelly Meagan , Qadri Firdausi , Ryan Edward T. , Kováč Pavol
Published: April 2019

The glycocluster-containing conjugates for a vaccine against cholera showed immunoreactivity comparable to conventional conjugates.
Transmembrane H+/Cl− cotransport activity of bis(amido)imidazole receptors
Authors: Shinde Sopan Valiba , Talukdar Pinaki
Published: April 2019

Bis(amide) appended imidazole having a sickle-shaped trivalent hydrogen-bonding structure reported as a transmembrane H+/Cl− symporter.
Shape control of nanostructured cone-shaped particles by tuning the blend morphology of A-b-B diblock copolymers and C-type copolymers within emulsion droplets
Authors: Kim Eun Ji , Shin Jae Man , Kim YongJoo , Ku Kang Hee , Yun Hongseok , Kim Bumjoon J.
Published: April 2019

An approach to blend AB-type block copolymers and C-type copolymers within the emulsion droplet is an efficient particle shape-engineering strategy.
A biomimetic strategy for the selective recognition of organophosphates in 100% water: synergies of electrostatic interactions, cavity embedment and metal coordination
Authors: Collin Solène , Giraud Nicolas , Dumont Elise , Reinaud Olivia
Published: April 2019

A biomimetic receptor allows selective recognition of organophosphates in water thanks to multipoint recognition associating coordination, electrostatics and cavity hosting.
Rotaxane-branched dendrimers with aggregation-induced emission behavior
Authors: Wang Xu-Qing , Wang Wei , Li Wei-Jian , Qin Yi , Yin Guang-Qiang , Jiang Wei-Ling , Li Xiaopeng , Wu Shuai , Yang Hai-Bo
Published: April 2019

By introducing a 9,10-distyrylanthrance (DSA) moiety as the core, we demonstrated the synthesis of a new family of rotaxane-branched dendrimers G1–G3 through the controllable divergent approach.
19F-GEST NMR: studying dynamic interactions in host–guest systems
Authors: Avram Liat , Bar-Shir Amnon
Published: April 2019

GEST NMR provides dynamic information on host–guest systems. It allows signal amplification of low concentrated complexes, detection of intermolecular interactions and quantification of guest exchange rates.
Reactive intermediates in naquotinib metabolism identified by liquid chromatography-tandem mass spectrometry: phase I metabolic profiling
Authors: Attwa Mohamed W. , Kadi Adnan A. , AlRabiah Haitham , Darwish Hany W.
Published: April 2019

LC-MS/MS was used to screen for in vitro metabolites of NQT formed during incubation with human liver microsomes (HLMs) and then evaluated the generation of reactive electrophiles using capturing agents.
Extracellular histones are clinically associated with primary graft dysfunction in human liver transplantation
Authors: Li Xiuhui , Gou Chunyan , Pang Yanhua , Wang Yakun , Liu Yan , Wen Tao
Published: April 2019

Extracellular histones have been involved in numerous inflammatory conditions such as ischemia/reperfusion (I/R) injury, trauma, and infection.
Y3Al5O12:Ce nanoparticles made by ionic-liquid-assisted particle formation and LiCl-matrix-treated crystallization
Authors: Gaiser Hannah F. , Kuzmanoski Ana , Feldmann Claus
Published: April 2019

Y3Al5O12:Ce3+ nanoparticles were prepared by a two-step approach (mean size: 40 nm; quantum yield: 51%) and embedded in polyester.
Efficient air-stable perovskite solar cells with a (FAI)0.46(MAI)0.40(MABr)0.14(PbI2)0.86(PbBr2)0.14 active layer fabricated via a vacuum flash-assisted method under RH > 50%
Authors: Chen Li , Cao Hui , Wang Shurong , Luo Yuxing , Tao Tao , Sun Jinwei , Zhang Mingdao
Published: April 2019

In this work, we present a new kind of perovskite, (FAI)0.46(MAI)0.40(MABr)0.14(PbI2)0.86(PbBr2)0.14, the vacuum flash-assisted solution processing (VASP) of which can be carried out under relative humidity (RH) higher than 50% in ambient air.
Integrated continuous flow/batch protocol for the photoreduction of ortho-methyl phenyl ketones using water as the hydrogen source
Authors: Aand Dnyaneshwar , Mahajan Bhushan , Pabbaraja Srihari , Singh Ajay K.
Published: April 2019

The direct hydrogenation of ketones (RRCO) with water to secondary alcohols under catalyst-free, minimal risk conditions, through the light-driven transfer hydrogenation platform.
Analysis of the oscillatory wetting–dewetting motion of a volatile drop during the deposition of polymer on a solid substrate
Authors: Zigelman Anna , Abo Jabal Mohammad , Manor Ofer
Published: April 2019

We employ a theoretical model to explain the wetting–dewetting motion of the contact line by incorporating opposing evaporation and Marangoni induced flows in the deposition process.
Coherent magnetic nanoinclusions induce charge localization in half-Heusler alloys leading to high-Tc ferromagnetism and enhanced thermoelectric performance
Authors: Lu R. , Lopez J. S. , Liu Y. , Bailey T. P. , Page A. A. , Wang S. , Uher C. , Poudeu P. F. P.
Published: April 2019

Coherent incorporation of magnetic nanoinclusions into a heavily doped semiconductor leads to overlapping bound magnetic polarons and a drastic reduction of the effective carrier density.
Ternary metal sulfides for electrocatalytic energy conversion
Authors: Fu Gengtao , Lee Jong-Min
Published: April 2019

Recent developments in various types of ternary metal sulfides (TMSs) for electrocatalytic energy conversion are summarized and discussed.
Improving the optical and crystal properties of ZnO nanotubes via a metallic glass quantum dot underlayer
Authors: Huang Bohr-Ran , Chu Jinn P. , Hsu Cheng-Liang , Greene Joseph E. , Chen You-Syuan , Chang Chia-Hao
Published: April 2019

In this study, high density (∼38 μm−2) ZnO nanotubes (NTs) were hydrothermally synthesized on a Cu47.2Zr42.1Al6.7Ti4.0 metallic glass quantum dot (MGQD)/glass substrate.
2D perovskite microsheets for high-performance photodetectors
Authors: Qian Liu , Sun Yilin , Sun Mengxing , Fang Zhimin , Li Lin , Xie Dan , Li Chun , Ding Liming
Published: April 2019

Square-shaped microsheets based on 2D perovskites (PEA)2SnI4−xBrx (x = 0, 1, 2) were prepared. A (PEA)2SnI4 microsheet photodetector gave a photoresponsivity of 3.29 × 103 A W−1 with a photoconductive gain of 8.68 × 103.
A versatile star-shaped organic semiconductor based on benzodithiophene and diketopyrrolopyrrole
Authors: He Qiao , Shahid Munazza , Panidi Julianna , Marsh Adam V. , Huang Wentao , Daboczi Matyas , Kim Ji-Seon , Fei Zhuping , Anthopoulos Thomas D. , Heeney Martin
Published: April 2019

A novel star-shaped π-conjugated oligomer containing a benzodithiophene core and four diketopyrrolopyrrole arms is reported.
Reply to the ‘Comment on “Synthesis and properties of a high dielectric constant copolymer of a copper phthalocyanine oligomer grafted to amino-capped polyimide”’ by G. Mezei,Journal of Materials Chemistry C, 2019,7, DOI: 10.1039/C8TC04076A
Authors: Chen Linlin , Ding Yichun , Hou Haoqing
Published: April 2019

We reply to the comment raised by Gellert Mezei on our paper regarding the exact chemical structure of the synthesized copper phthalocyanine oligomer (o-CuPc).
A partially-planarised hole-transporting quart-p-phenylene for perovskite solar cells
Authors: Mora-Fuentes Juan P. , Cortizo-Lacalle Diego , Collavini Silvia , Strutyński Karol , Tress Wolfgang R. , Saliba Michael , Zakeeruddin Shaik M. , Kosta Ivet , Melle-Franco Manuel , Grätzel Michael , Delgado Juan Luis , Mateo-Alonso Aurelio
Published: April 2019

Herein, we describe the synthesis of a hole transporting material based on a partially planarised quart-p-phenylene core incorporating tetraketal and diphenylamine substituents that show optimal energy levels and solubility for perovskite solar cell applications.
Which isomer is better for charge transport: anti- or syn-?
Authors: Hu Peng , Ye Jun , Jiang Hui
Published: April 2019

This review discusses the isomeric effect on the charge transport of organic semiconductors experimentally and theoretically.
Oxysterol research: a brief review
Authors: Griffiths William J. , Wang Yuqin
Published: April 2019

In the present study, we discuss the recent developments in oxysterol research. Exciting results have been reported relating to the involvement of oxysterols in the fields of neurodegenerative disease, especially in Huntington's disease, Parkinson's disease and Alzheimer's disease; in signalling and development, in particular, in relation to Hedgehog signalling; and in cancer, with a special focus on (25R)26-hydroxycholesterol. Methods for the measurement of oxysterols, essential for understanding their mechanism of action in vivo, and valuable for diagnosing rare diseases of cholesterol biosynthesis and metabolism are briefly considered.
Amino acid transporters in the regulation of insulin secretion and signalling
Authors: Javed Kiran , Fairweather Stephen J.
Published: April 2019

Amino acids are increasingly recognised as modulators of nutrient disposal, including their role in regulating blood glucose through interactions with insulin signalling. More recently, cellular membrane transporters of amino acids have been shown to form a pivotal part of this regulation as they are primarily responsible for controlling cellular and circulating amino acid concentrations. The availability of amino acids regulated by transporters can amplify insulin secretion and modulate insulin signalling in various tissues. In addition, insulin itself can regulate the expression of numerous amino acid transporters. This review focuses on amino acid transporters linked to the regulation of insulin secretion and signalling with a focus on those of the small intestine, pancreatic β-islet cells and insulin-responsive tissues, liver and skeletal muscle. We summarise the role of the amino acid transporter B0AT1 (SLC6A19) and peptide transporter PEPT1 (SLC15A1) in the modulation of global insulin signalling via the liver-secreted hormone fibroblast growth factor 21 (FGF21). The role of vesicular vGLUT (SLC17) and mitochondrial SLC25 transporters in providing glutamate for the potentiation of insulin secretion is covered. We also survey the roles SNAT (SLC38) family and LAT1 (SLC7A5) amino acid transporters play in the regulation of and by insulin in numerous affective tissues. We hypothesise the small intestine amino acid transporter B0AT1 represents a crucial nexus between insulin, FGF21 and incretin hormone signalling pathways. The aim is to give an integrated overview of the important role amino acid transporters have been found to play in insulin-regulated nutrient signalling.
Does Animation Facilitate Understanding of Graphic Symbols Representing Verbs in Children With Autism Spectrum Disorder?
Authors: Schlosser Ralf W. , Brock Kris L. , Koul Rajinder , Shane Howard , Flynn Suzanne
Published: April 2019

Purpose

The effects of animation on identification of graphic symbols for verbs were studied using the Autism Language Program Graphic Symbols Set in children diagnosed with mild-to-severe autism spectrum disorder between the ages of 3 and 7 years.

Method

The participants were randomly assigned to an animated symbol condition or a static symbol condition. Static symbols were spliced from the animated symbols to ensure that the symbols differed only in terms of the absence or presence of movement. The participants were asked to identify a target symbol among foils given the spoken label.

Results

There were no significant differences between the groups with respect to chronological age, autism severity, and receptive target verb knowledge. An independent
t
test revealed that animated symbols were more readily identified than static symbols.

Conclusions

Animation enhances the identification of verbs in children with autism spectrum disorder. Clinicians are encouraged to take advantage of animation when introducing graphic symbols representing verbs. Limitations and implications for future research are discussed.
Integrating Lesbian, Gay, Bisexual, Transgender, and Queer Issues Into the Multicultural Curriculum in Speech-Language Pathology: Instructional Strategies and Learner Perceptions
Authors: Mahendra Nidhi
Published: April 2019

Purpose

Instructors teaching courses on diversity issues in communication sciences and disorders do not typically or uniformly teach about lesbian, gay, bisexual, transgender, and queer (LGBTQ) culture. The purpose of this article is to provide readers with a detailed description of the importance, historical context, and pedagogical methods for integrating LGBTQ content and history into courses on diversity issues for speech-language pathology and audiology students.

Conclusion

Content on LGBTQ culture and history merits inclusion in the curricula for future health care providers given the backdrop of historic and continuing discrimination as well as persistent health disparities among LGBTQ-identified persons. This article provides one example of the instructional design of an LGBTQ teaching module, embedded into a required course on cultural and linguistic diversity for speech-language pathology students. This preliminary investigation revealed that learners responded positively to this content module, demonstrating interest and engagement as well as improved awareness and knowledge for better serving LGBTQ clients.
Mixed construction of OOC for optical code division multiple access networks
Authors: Li Xiyang , Shum Kenneth W.
Published: April 2019

Optical orthogonal codes play an important role in optical code division multiple access networks and optical wireless systems. In this study, by combining combinatorial design and meta‐heuristic search algorithm, a mixed construction of ‐OOCs is proposed. The mixed construction enjoys the benefits of both mathematical methods and search algorithms and can be used to produce OOCs with large and flexible parameters. Numerical results show that some of the OOCs obtained by this construction have more codewords in comparison with the construction method using outer‐product matrix.
SIMO subcarrier PSK FSO links with phase noise and non‐zero boresight pointing errors over turbulence channels
Authors: Varotsos George K. , Nistazakis Hector E. , Gappmair Wilfried , Sandalidis Harilaos G. , Tombras George S.
Published: April 2019

Terrestrial free‐space optical (FSO) communication systems with subcarrier intensity modulation have experienced a particular research attention in the recent past. However, their performance strongly degrades in the presence of atmospheric turbulence, pointing errors, and phase noise impairments. In order to overcome these limitations, the authors consider a receiver diversity scheme of a typical subcarrier phase‐shift keying (PSK) system and investigate the performance by means of the average symbol error probability (ASEP). They assume a wide range of turbulence conditions, non‐zero boresight pointing errors, and phase noise strengths described through the gamma‐gamma, Beckmann, and Tikhonov distributions, respectively. Novel approximate ASEP expressions are derived for single‐input single‐output and single‐input multiple‐output (SIMO) configurations. Appropriate numerical results are depicted and validated by Monte Carlo simulations.