bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical results and survivorship of the Mathys Affinis Short, Short Stem Total Shoulder Prosthesis
Authors: Karssiens Timothy James , Gill James Ritchie , Sunil Kumar Karadi Hari , Sjolin Søren Upton
Published: January 2021

Aims

The Mathys Affinis Short is the most frequently used stemless total shoulder prosthesis in the UK. The purpose of this prospective cohort study is to report the survivorship, clinical, and radiological outcomes of the first independent series of the Affinis Short prosthesis.

Methods

From January 2011 to January 2019, a total of 141 Affinis Short prostheses were implanted in 127 patients by a single surgeon. Mean age at time of surgery was 68 (44 to 89). Minimum one year and maximum eight year follow-up (mean 3.7 years) was analyzed using the Oxford Shoulder Score (OSS) at latest follow-up. Kaplan-Meier survivorship analysis was performed with implant revision as the endpoint. Most recently performed radiographs were reviewed for component radiolucent lines (RLLs) and proximal humeral migration.

Results

Five shoulders underwent revision surgery (3.5%); three for rotator cuff failure, one for infection, and one for component malposition. Survivorship of the implant was 95.4% (95% confidence interval 90.1% to 97.9%) at five and nine years. Mean OSS improved significantly compared to preoperative values from 19.0 (1 to 35) to 43.3 (7 to 48) (p < 0.001). Radiological analysis was undertaken for 99 shoulders. This revealed humeral RLLs in one case (1%), glenoid RLLs in 15 cases (15.2%), and radiological rotator cuff failure in 22 cases (22.2%).

Conclusion

This prospective cohort study shows encouraging short- to mid-term survivorship and clinical and radiological results for the Mathys Affinis Short, Short Stem Total Shoulder Prosthesis. Level of Evidence: IV Cite this article: Bone Jt Open 2021;2(1):58–65.
Anthocyanin profile of Syzygium oleana young leaves and fruits using triple quadrupole mass spectrometer: Identification of a new peonidin
Authors: Anggraini Tuty , Syukri Daimon , Manasikan Thammawong , Nakano Kohei
Published: January 2021

Abstract. Anggraini T, Syukri D, Manasikan TW, Nakano K. 2020. Anthocyanin profile of Syzygium oleana young leaves and fruits using triple quadrupole mass spectrometer: Identification of a new peonidin. Biodiversitas 21: 5893-5900. Anthocyanin is pigment present in many red, blue and purple colored plants that can be used as stable food-safe colorings and also offer health benefits as antioxidants. Syzygium oleana, with its dark purple fruit and red leaves, is one hitherto unexplored source of anthocyanin. This study is the first to establish the anthocyanin profile of S. oleana leaves and fruit exploiting the speed and accuracy of Multiple Reaction Monitoring (MRM) with a triple quadrupole mass spectrometer. The anthocyanin compounds in the leaves and fruit of S. oleana were found to be derivatives of agliconpeonidin, cyanidin derivative, delphinidin. It was found that while both leaves and fruit of S. oleana contain the anthocyanin precursors cyanidin, delphinidin, petunidin, and peonidin. Fruit contains the anthocyanin malvidin and a large amount of petunidin not present in the leaves. In detail: anthocyanin found in S. oleana leaves were Cyanidin 3-galactoside, cyanidin with m/z 611, Delphinidin 3-O-β-D-glucopyranoside, and unknown peonidin. Anthocyanin in S. oleana fruits was cyanidin with m/z 449.1, delphinidin 3-O-β-D-glucopyranoside, petunidin with m/z 476, Malvidin 3-O-β-D-glucopyranoside, and an unknown peonidin. Fruit could be a better anthocyanin source and more effective as colorant than leaves, while leaves contain a stronger as yet unidentified antioxidant.
Combined approach using circular intensity differential scattering microscopy under phasor map data analysis
Authors: Mohebi Ali , Le Gratiet Aymeric , Marongiu Riccardo , Callegari Fabio , Bianchini Paolo , Diaspro Alberto
Published: January 2021

Circular intensity differential
scattering (CIDS) is based
on the analysis of circular polarized light scattering and has been
proven to be an interesting label-free microscopy technique sensitive
to the chiral organization at the submicroscopic level. However, this
approach averages the localized contrasts related to the sample
polarimetric properties in the illumination volume. Additionally, the
detection sensitivity suffers from the confinement of
the mixture of structures, and it becomes an arduous
task to discriminate the source of the signal. In this work, we show
that a phasor map approach combined with CIDS microscopy has provided
an intuitive view of the sample organization to recognize the presence
of different molecular species in the illumination volume. The data
represented in terms of polarization response mapped to a single point
called a phasor also have the potential to pave the way for the
analysis of large data sets. We validated this method by numerical
simulations and compared the results with that of experimental data of
optical devices of reference.
Methylation of the PTENP1 pseudogene as potential epigenetic marker of age-related changes in human endometrium
Authors: Kovalenko Tatyana F. , Morozova Ksenia V. , Pavlyukov Marat S. , Anufrieva Ksenia S. , Bobrov Mikhail Yu. , Gamisoniya Alina M. , Ozolinya Lyudmila A. , Dobrokhotova Yulia E. , Shakhparonov Mikhail I. , Patrushev Lev I.
Published: January 2021

The processed pseudogene PTENP1 is involved in the regulation of the expression of the PTEN and acts as a tumor suppressor in many types of malignances. In our previous study we showed that PTENP1 methylation is present not only in tumor, but also in normal endometrium tissues of women over 45 years old. Here we used methylation-specific PCR to analyze methylation status of CpG island located near promoter region of PTENP1 in malignant and non-malignant endometrium tissues collected from 236 women of different age groups. To confirm our results, we also analyzed RNA sequencing and microarray data from 431 women with endometrial cancer from TCGA database. We demonstrated that methylation of PTENP1 is significantly increased in older patients. We also found an age-dependent increase in the level of PTENP1 expression in endometrial tissue. According to our data, PTENP1 methylation elevates the level of the pseudogene sense transcript. In turn, a high level of this transcript correlates with a more favorable prognosis in endometrial cancer. The data obtained suggested that PTENP1 methylation is associated with age-related changes in normal and hyperplastic endometrial tissues. We assumed that age-related increase in PTENP1 methylation and subsequent elevation of its expression may serve as a protective mechanism aimed to prevent malignant transformation of endometrial tissue in women during the perimenopause, menopause, and postmenopause periods.
A reliable algorithm to compute the approximate solution of KdV-type partial differential equations of order seven
Authors: Saleem Sidra , Hussain Malik Zawwar , Aziz Imran
Published: January 2021

The approximate solution of KdV-type partial differential equations of order seven is presented. The algorithm based on one-dimensional Haar wavelet collocation method is adapted for this purpose. One-dimensional Haar wavelet collocation method is verified on Lax equation, Sawada-Kotera-Ito equation and Kaup-Kuperschmidt equation of order seven. The approximated results are displayed by means of tables (consisting point wise errors and maximum absolute errors) to measure the accuracy and proficiency of the scheme in a few number of grid points. Moreover, the approximate solutions and exact solutions are compared graphically, that represent a close match between the two solutions and confirm the adequate behavior of the proposed method.
Treatment burden experienced by patients with lung cancer
Authors: El-Turk Nicole , Chou Michael S. H. , Ting Natasha C. H. , Girgis Afaf , Vinod Shalini K. , Bray Victoria , Dobler Claudia C.
Published: January 2021

Introduction

Patients’ burden from lung cancer treatment is not well researched, but this understanding can facilitate a patient-centred treatment approach. Current models of treatment burden suggest it is influenced by a patient’s perception of their disease and treatment and their capacity to do the work required to treat their disease.

Methods

Sixteen patients and 1 carer who were undergoing or had completed conventional or stereotactic ablative radiotherapy, chemotherapy or immunotherapy for lung cancer in the last 6 months participated in a semi-structured interview. A treatment burden framework was used with three main themes: a) treatment work, b) consequences of treatment and c) psychosocial factors affecting treatment burden.

Results

The majority of patients did not feel unduly burdened by treatment tasks, despite having a large treatment-associated workload. Many saw treatment as a priority, causing them to restructure their life to accommodate for it. Patients wished that they would have been better informed about the lifestyle changes that they would have to make before treatment for lung cancer commenced and that the health service would provide services to assist them with this task.

Discussion

While there was a large burden associated with lung cancer treatment, patients felt motivated and equipped to manage the workload because the disease was considered severe and life-threatening, and the treatment was seen as beneficial. Before initiating treatment for lung cancer, patients should be informed about lifestyle changes they likely have to make and should be offered assistance.
DNA-thioguanine nucleotide as a treatment marker in acute lymphoblastic leukemia patients with NUDT15 variant genotypes
Authors: Ju Hee Young , Lee Ji Won , Cho Hee Won , Hyun Ju Kyung , Ma Youngeun , Yi Eun Sang , Yoo Keon Hee , Sung Ki Woong , Choi Rihwa , Koo Hong Hoe , Lee Soo-Youn
Published: January 2021

Background

Large inter-individual variations in drug metabolism pose a challenge in determining 6-mercaptopurine (6MP) doses. As the last product of 6MP metabolism, DNA-thioguanine nucleotide (DNA-TGN) could reflect the efficacy of 6MP, especially in patients harboring variants in the 6MP metabolism pathway. The aim of this study was to investigate the clinical significance of DNA-TGN monitoring in Korean pediatric acute lymphoblastic leukemia (ALL) patients, focusing on the NUDT15 genotype.

Methods

The subjects of this study were patients who underwent ALL treatment with 6MP. Tests for the NUDT15 and TPMT genotypes were performed, and prospective DNA-TGN and erythrocyte TGN samples were collected after two weeks or more of 6MP treatment. DNA-TGN was quantified using the liquid chromatography-tandem mass spectrometry method.

Results

A total of 471 DNA-TGN measurements in 71 patients were analyzed, which ranged from 1.0 to 903.1 fmol thioguanine/μg DNA. The 6MP intensity demonstrated a significant relationship with DNA-TGN concentration (P<0.001). Patients harboring NUDT15 variants were treated with a lower dose of 6MP (P<0.001); however, there was no significant difference in DNA-TGN concentration when compared to patients carrying wild-type NUDT15 (P = 0.261). These patients also presented higher variation in DNA-TGN levels (P = 0.002) and DNA-TGN/6MP intensity (P = 0.019) compared to patients carrying wild-type NUDT15. DNA-TGN concentration did not show a significant correlation with WBC count (P = 0.093).

Conclusions

Patients harboring NUDT15 variants demonstrated similar DNA-TGN concentrations even at low doses of 6MP and showed high variability in DNA-TGN. Particularly in patients with NUDT15 variants who need a reduced 6MP dose, DNA-TGN could be applied as a useful marker to monitor the therapeutic effect of 6MP.
Risk factors of heart failure among patients with hypertension attending a tertiary hospital in Ibadan, Nigeria: The RISK-HHF case-control study
Authors: Oguntade Ayodipupo S. , Ajayi IkeOluwapo O.
Published: January 2021

Aim

Hypertension is the leading cause of heart failure (HF) in sub-Saharan Africa. Preventive public health approach to reduce the scourge of HF must seek to understand the risk factors of HF in at-risk populations. The aim of this study was to characterize the risk factors of HF among patients with hypertension attending a cardiology clinic.

Methods and results

One hundred and one (101) case-control age- and sex-matched pairs were recruited. The study population were adults with a clinical diagnosis of hypertensive HF (cases) and individuals with systemic hypertension without HF. They were interviewed and evaluated for cardiovascular risk factors. Associations between variables were tested with chi square test, Fisher’s exact test and independent sample t test as appropriate. Logistic regression modelling was used to determine the independent risk factors of hypertensive HF (HHF) in the study population while ‘punafcc’ package in stata12 was used to calculate the population attributable fraction (PAF) of the risk factors. Suboptimal medication adherence was the strongest adverse risk factor of HHF (medium adherence aOR: 3.53, 95%CI: 1.35–9.25; low adherence aOR: 9.44, 95%CI: 3.41–26.10) with a PAF of 67% followed by dipstick proteinuria (aOR: 4.22, 95%CI: 1.62–11.02; PAF: 34%) and alcohol consumption/day per 10grams (aOR: 1.23, 95%CI: 1.02–1.49; PAF: 22%). The protective risk factors of HHF were use of calcium channel blockers (aOR 0.25, 95%CI: 0.11–0.59; PAF: 59%), then daily fruits and vegetable consumption (aOR 0.41, 95%CI: 0.17–1.01; PAF: 46%), and eGFR (aOR 0.98, 95%CI: 0.96–0.99; PAF: 5.3%).

Conclusions

The risk factors of HHF are amenable to lifestyle and dietary changes. Public health interventions and preventive cardiovascular care to improve medication adherence, promote fruit and vegetable consumption and reduce alcohol consumption among patients with hypertension are recommended. Renoprotection has utility in the prevention of HF among hypertensives.
The potential of microdialysis to estimate rifampicin concentrations in the lung of guinea pigs
Authors: Lanni Faye , Burton Neil , Harris Debbie , Fotheringham Susan , Clark Simon , Skinner Oliver , Wiblin Nathan , Dennis Mike , Armstrong Stuart , Davies Geraint , Williams Ann
Published: January 2021

Optimised pre-clinical models are required for TB drug development to better predict the pharmacokinetics of anti-tuberculosis (anti-TB) drugs to shorten the time taken for novel drugs and combinations to be approved for clinical trial. Microdialysis can be used to measure unbound drug concentrations in awake freely moving animals in order to describe the pharmacokinetics of drugs in the organs as a continuous sampling technique. The aim of this work was to develop and optimise the microdialysis methodology in guinea pigs to better understand the pharmacokinetics of rifampicin in the lung. In vitro experiments were performed before progressing into in vivo studies because the recovery (concentration of the drug in the tissue fluid related to that in the collected dialysate) of rifampicin was dependent on a variety of experimental conditions. Mass spectrometry of the dialysate was used to determine the impact of flow rate, perfusion fluid and the molecular weight cut-off and membrane length of probes on the recovery of rifampicin at physiologically relevant concentrations. Following determination of probe efficiency and identification of a correlation between rifampicin concentrations in the lung and skeletal muscle, experiments were conducted to measure rifampicin in the sacrospinalis of guinea pigs using microdialysis. Lung concentrations of rifampicin were estimated from the rifampicin concentrations measured in the sacrospinalis. These studies suggest the potential usefulness of the microdialysis methodology to determine drug concentrations of selected anti-TB drugs to support new TB drug development.
Sobre cocaína y embriaguez: ética y estética en Freud y Nietzsche
Authors: Zengotita Alonso
Published: January 2021

Las temáticas de la influencia de la cocaína en Freud y la embriaguez en Nietzsche han sido escasamente laboradas; cuando lo han sido, en el primero generalmente se ha abordado desde una perspectiva histórica, o relativa al consumo de Freud; en el segundo, como uno más de los elementos que hacen a la concepción del arte –esta última, extensamente trabajada. El objetivo del presente trabajo es dar cuenta que la embriaguez y la influencia de la cocaína, lejos de ser aspectos episódicos, laterales o superados, marcan aquello de la perspectiva estético-ética que es desplegado de modo continuo a lo largo de las obras de Nietzsche y Freud, modelando la conceptualidad y las consideraciones sobre la vida, la guerra, los hombres superiores, la aptitud de analista, la cultura de la época- y en  términos más amplios: la relación entre el mundo y el viviente.
Escribir desde el dolor: identidad y performatividad en Lo que no tiene nombre (2013), de Piedad Bonnett
Authors: Marín Cobos Nieves
Published: January 2021

Este trabajo se propone articular una propuesta hermenéutica amplia para abordar la performatividad en escrituras del yo surgidas del dolor por la pérdida del ser amado. Se analizará Lo que no tiene nombre (2013), de Piedad Bonnett: en un giro performativo final, la voz poética asegura haber vuelto a parir al hijo, en cuyo suicidio indaga, mediante la escritura de la obra. Desde la filosofía del lenguaje, la pragmática discursiva y otras teorías sobre lo performativo, se verá cómo la maternidad culpable es reconfigurada mediante un discurso poético investido de una fuerte carga somática. La inefabilidad del hecho fúnebre es trascendida en aras de una performatividad que origina una maternidad ad infinitum adhiriéndose a una supra-realidad del deseo que se revela como (im)posible por sus propias condiciones intrínsecas de legitimación.
A turizmus magyar vonzerőiről (Hungarian tourist attractions)
Authors: Kovács Tibor , Papanek Gábor , Papanek Zsuzsanna
Published: January 2021

A hazai turizmus gyakorlatával kapcsolatos vizsgálatok tapasztalatai nyomán az egri Eszterházy Károly Főiskola (EKF) turizmusmenedzsment-kurzusának oktatói célszerűnek ítélték a témára vonatkozó tananyag fejlesztését. A cikk szerzői azt remélik azonban, hogy az utóbbi munka egyes megállapításai minden, a gazdasági földrajz, a turizmus (idegenforgalom), a térségfejlesztés valamely szegmensével foglalkozó szakembernek, kiemelten: vezetőnek – s több más gazdasági ág illetékeseinek – az érdeklődésére számot tarthatnak, ezért ezekről jelen cikkben is beszámolnak. _____ In this article the authors reviewed first the different types of tourist attractions (destinations) and they analysed the common evaluation methods of their attractiveness (e.g. the possibilities and limits of the tourism statistics). Then they tried to display the existing information on the main Hungarian attractions and their attractiveness. In this study revealed that there exist no generally recognized list of the most visited attractions, and the real measures of their attractiveness are not known either. The authors emphasize that shaping a comprehensive concept on the above mentioned issue would highly contribute to the elaboration of a successful and achievable tourism strategy, thus it would be of great importance.
A számviteli érdekhordozói elméletek evolúciója és a szabályozás – klasszikus tézisek és új irányok a pénzügyi beszámolásban (Evolution of the financial accounting stakeholder theories and the regulation – classic theses and new ways in the financial report)
Authors: Lakatos László Péter
Published: January 2021

A modernkori számvitel egyik alapvető kérdése, hogy a pénzügyi beszámolás címzettjét – az érdekhordozókat – miként lehet azonosítani. Ez a törekvés már a klasszikus, azóta meghaladottá vált elméletekben is központi szerepet töltött be és modern, posztmodern elméletekben kulcsfontosságúvá vált. A tapasztalatok alapján az azonosított érdekhordozók köre módosult, bővült. Ennek a fejlődésnek a vizsgálata során a számvitel számos olyan ismérvét sikerült azonosítani, amely segítségével a vonatkozó szabályok tökéletesíthetők. Emellett az evolúció vizsgálata segítségével közvetlenül is megfigyelhetővé vált az, hogy a számvitelt extern módon szabályozó hatalom szükségessége milyen feltételek teljesítése mellett igazolható. A vizsgálat során azonosíthatóvá váltak olyan helyzetek, amikor a számviteli szabályozó és „kívülről irányított” pénzügyi beszámolás szuboptimális helyzethez vezet. A cikk az érdekhordozói elméletek fejlődését a klasszikus felfogásoktól indulva mutatja be. Feltárja, hogy a modern – jelenleg elfogadott – koalíciós vállalatfelfogás miben hozott újat, elsősorban miként hívta életre az extern szabályozót. _____ One of the key problems of the modern financial accounting is how to define the stakeholders. This problem was already a key issue in the already outdated classical stakeholder theories. Research and experience noted that the group of stakeholders has widened and has been modified. Through this evolution researchers identified many characteristics of financial reporting through which the regulation could have been improved. This advance pointed out which are the situations when the existence of an extern accounting regulator may be justified, since under given circumstances this existence led to suboptimal scenario. This paper deals with the stakeholder theories, starting with the classical ones. The article points out how did the currently accepted theory changed the assertions of the previous one and how was the external regulator created as an inevitable consequence. The paper also highlights the main issues raised by the post-modern theories; those, which try to fit the current questions into the current stakeholder models. The article also produces a Hungarian evidence for the previously mentioned suboptimal scenario, where the not tax-driven regulation proves to be suboptimal.
Az autóipar szerkezeti átrendeződése – Vállalati stratégiák és a válság hatásai (Structural change in the automotive industry – corporate strategies and the impact of the crisis)
Authors: Szalavetz Andrea
Published: January 2021

Az írás a globális értékláncok élén álló autóipari cégek világgazdasági válságra adott reakcióit foglalja össze. Megállapítja, hogy a válságnak messze nincs vége: az iparág globális átrendeződése folytatódik. A globális értékláncokba sikeresen betagozódott közép-európai autóipari klaszter ezeknek a folyamatoknak mindmáig nyertese volt. Számolni kell azonban azzal, hogy továbbra is sok a technológiai és a piaci bizonytalanság: az új szereplők belépése, új üzleti modellek elterjedése hosszabb távon felboríthatja a jelenlegi status quo-t, és veszélyeztetheti a hagyományos autóipari befektetőiket munkabér-alapú versenyképességgel megtartani próbáló közép- és kelet-európai országok pozícióit. Az autóipari működő tőkét fogadó közép-kelet-európai országok számára hosszabb távon veszélyt jelenthet az autóipari üzleti modellek átalakulása, a gyártás teljes kiszervezése komplex gyártási szolgáltatást vállaló cégekhez, mivel ez esetben az értéklánc vezető vállalatai bezárhatják a régióban működő gyártóbázisaikat. Az értékláncok élén álló globális cégek „menekülés a minőségbe” stratégiája helyi szinten is követhető, követendő, a működő tőkét fogadó országok versenyképessége kizárólag a helyi leányvállalatok állandó „feljebb lépésével” tartható fenn. ______ This paper summarizes lead firms’ reactions to crisis in global automotive value chains. The paper advances five theses. Author argues that crisis is not over yet, the global restructuring of the industry continues. Actors in the CEE automotive cluster have successfully become integrated into global value chains and have thereby been the winners of past restructuring processes. Nevertheless, technological and market uncertainties prevail: entry of new economic actors and the diffusion of new business models may, in the long run, disrupt the current status quo and jeopardise the world economic position of CEE countries that have been relying solely on their labour cost advantages to sustain direct investment inflows in their automotive industries. In the long run the automotive industries of Central and Eastern European (CEE) economies may become threatened by the transformation of the prevailing automotive business model, the outsourcing of manufacturing and related support activities to complex manufacturing services providers, which could lead to the closure of lead firms’ manufacturing facilities in CEE. Lead firms’ increased focus on high quality high value adding activities strategy can and should be followed by local subsidiaries through a continuous strive for upgrading.
A tranzakciós költségek és a szabványosítás kapcsolata (Relationship between transaction costs and standardization)
Authors: Kovács István
Published: January 2021

Az elmúlt néhány évtizedben a szabványosítás terén igen komoly változások mentek végbe. Ugrásszerűen megnőtt a szabványok száma, és jelentősen átalakult a szabványosítás folyamata is. Ezzel párhuzamosan a téma gazdasági hatásaival foglalkozó kutatások száma is megsokszorozódott, ami elsősorban a hálózati externáliák irodalmának robbanásszerű gyarapodásának köszönhető. Jelen tanulmány – az elméletek fősodrától eltérően – a tranzakciós költségek elméletében (TKE) helyezi el a szabványosítást. A szabványok és a tranzakciós költségek kapcsolatáról már születtek korábban is tanulmányok, de ezek a szabványoknak a tranzakciós költségekre gyakorolt hatásaira fókuszáltak. A tanulmány ezzel szemben arra helyezi a hangsúlyt, hogy azonosítsa a tranzakciós költségeknek a szabványosításra gyakorolt hatásait. A kutatás célja, hogy olyan elméleti alapot adjon, amelyben a témakör átfogóan elemezhető. A fő kutatási kérdés az, hogy mitől függ az, hogy melyik mechanizmus kereteiben érdemes a szabványosítást lebonyolítani. ________ Significant changes have characterized the last few decades of standardization. The number of standards has dramatically increased and processes of standardization have also changed a lot. At the same time the amount of researches that are concerned with the economic impact of standardization has also multiplied due to the boom in the literature of network externalities. Unlike the mainstream, this paper places standardization in the theory of transaction cost economics. Although there are earlier papers that are concerned with the relationship between standards and transaction costs, these studies focus on the impact of standards on transaction costs. In contrast, this paper lays emphasis on the identification of the impact of transaction costs on standardization. This study aims to provide a theoretical basis for the comprehensive analyses. The main research question: What determines which coordination mechanism is used to evolve a standard?
Social Dominance and familiarity modulate prosocial decision-making in rats
Authors: Gachomba Michael , Esteve Joan , Sanz Maroto Aroa , Márquez Cristina
Published: January 2021

Prosocial behaviors i.e., actions that benefit others are pervasive in the animal kingdom, being essential for social bonding and cooperation. Several factors have been proposed to modulate prosocial behaviors, such as the familiarity of the partner and the social status of the interacting individuals. However, little is know about the behavioral and brain mechanisms that promote these interesting modulations. To target these questions, we investigate the effects of social context on prosocial behavior in rats, an animal model with rich social interactions and amenable of neural circuits manipulation. We previously showed that rats display prosocial choices in the absence of self-benefit (Márquez et al., 2015). Here we ask whether this kind decision-making is modulated by the familiarity and the social status of the interacting animals. In order to gain insights into the behavioral mechanisms underlying prosocial choices, we performed fine-grained quantification of social interactions, with subsecond resolution, using a custom-made automated tracking system for animals body parts detection.
Depictions of psychopathology and mental health issues in music: themes and musical genres
Authors: Pavez Fabián , Saura Erika , Pérez Gemma , Marset Pedro
Published: January 2021

Introduction. In previous communications we have proposed that the analysis of cultural products related to art, and music in particular, can inform us about the social representations of psychiatry and mental illness. This topic is not irrelevant to our clinical practice, since it favors a better understanding about what are the meanings of our profession and its scope of practice for our patients and general population. In this work, we focused on portrayals of psychopathology in music and the musical genres associated.

Objectives. By exploring studies addressing depictions of mental disorders or mental health concerns in music, we intend: - to assess the distribution of psychopathological themes alluded; and - to characterize the most studied musical genres that are associated to portrayals of mental disorders or mental health concerns.

Methods. Starting from a previous systematic review of studies addressing depictions of mental disorders or mental health issues in music, thirty-seven articles are examined. Frequency of portrayed themes and musical genres associated are presented.

Results/Conclusion. As we can expect, references to substance use in music are the most frequently studied. Studies addressing references to 'madness' in music are frequent too, but in a lesser extent. Other mental health issues depicted are: affective disorders; suicide; sexuality and gender; personality disorders; self-destructive behavior; resilience; as well as general links between music and mental illness/psychiatry. Studies addressing substance use are mostly focused on multiple genres (based in popularity rankings). With regards substance use, Rap and Rock are two genres specifically studied. Links between country music, alcohol use and suicide have been described in literature. Rock and Opera are the genres more frequently associated with references to 'madness'.
Gestão de resíduos sólidos em serviços de saúde:
Authors: Nascimento Patrícia Maria Pereira do
Published: January 2021

O presente artigo tem por objetivo demonstrar como a Educação Ambiental, em sua abordagem crítica, pode oferecer subsídios para a atuação do Técnico em Segurança do Trabalho, em Serviços de Saúde, que elaborarem e implementarem o Plano de Gestão de Resíduos Sólidos. Parte-se da hipótese que a abordegam crítica trará uma compreensão e uma prática de Gerenciamento de Resíduos Sólidos em Serviços de Saúde que vá além do mero cumprimento da legislação ambiental, ao buscar a melhoria na qualidade dos processos de Gestão de Resíduos. Para tanto, considerou-se a legislação vigente e a literatura pertinente sobre o tema, a partir de uma pesquisa documental. Conclui-se que a partir do olhar da Educação Ambiental Crítica, o ser humano passa a ser visto como elemento central no que cerne a Saúde e Segurança do Trabalho, considerando a relação dele com a natureza e o ambiente produtivo.
A cultura do maracatu: subsídios para a educação ambiental nas escolas / The maracatu culture: subsidies for environmental education in schools
Authors: Lima Suênnia Keylla de Araújo , Fernandes Múcio Luiz Banja
Published: January 2021

A Educação Ambiental deve se realizar de forma diferenciada em cada meio para que se adapte às respectivas realidades, trabalhando com seus problemas específicos e suas soluções próprias em respeito à cultura, aos hábitos, aos aspectos psicológicos, às característica biofísicas e socioeconômicas de cada localidade. Nesse sentido, o estudo descrito neste trabalho buscou investigar as potencialidades da cultura do Maracatu no fortalecimento da prática em Educação Ambiental numa escola de Ensino Médio de Nazaré da Mata–Pernambuco/Brasil. Na investigação, utilizou-se a abordagem quali-quantitativa, seguindo os procedimentos da pesquisa-ação. Os resultados obtidos com a pesquisa permitiram constatar que para que a sala de aula seja um ambiente mais atrativo e significativo para os alunos, é importante que no processo de ensino aprendizagem o professor tome como base a região em que estes se encontram, atrelando-a a sua comunidade, essa prática   desenvolverá valores e costumes que levarão à transformação nos aspectos naturais e sociais para a conservação do meio ambiente, necessário à qualidade de vida e a sua sustentabilidade.
Black Lives Matter!: pelo reconhecimento da igualdade de direitos para a população afrodescendente
Authors: Souza Vilma Aparecida de , Silva Maria Vieira , Richter Leonice Matilde
Published: January 2021

A luta contra o racismo, em suas multifacetadas manifestações, é incessante e ininterrupta, no entanto, durante o mês de novembro, as diferentes expressões antirracistas se potencializam em razão do Dia da Consciência Negra, celebrado em 20 de novembro . A data concerne ao dia da morte de Zumbi dos Palmares (em 1695), um dos ícones da luta contra o sistema escravista e símbolo do Quilombo Resistência, mas também nos remete à relevância de debates e reflexões sobre os processos de desconstrução do racismo estrutural; à valorização da cultura africana; a problematização das desigualdades vivenciadas pela população negra em todas as instâncias do tecido social como também a necessidade de políticas públicas para mitigar os efeitos perversos derivados de séculos de injustiças contra os negros e discriminação racial.
Tough, Rugged, and Evolving Masculinity: Harry Compton, an Enslaved and Free Black Man in Eighteenth- and Early Nineteenth-Century New Jersey
Authors: Marshall Kenneth E.
Published: January 2021

This article explores the little known yet intriguing life of Harry Compton (c. 1743–c. 1814), who first comes to our attention in the 1883 narrative of the life of his famed granddaughter, Silvia Dubois. An enslaved person turned independent businessman, Compton constructed a complex and evolving concept of masculinity in the face of oppression, encouraging us to understand black masculinity in slavery and freedom as a life-long pursuit of self-empowerment and personal reinvention. His story, which occurred mostly in rural New Jersey, adds nuance to scholars’ understanding of early black masculinity as a public performance that showcased one’s power and authority, or self-worth, while also providing an important example of black masculinity as a developing process. In telling Compton’s story, the article advances a number of narrative threads pertaining to eighteenth- and early nineteenth-century New Jersey, including slavery, gender, culture and economy, and the law. An analysis of Compton allows the reader to learn a great deal about the world in which he lived and, ultimately, overcame through his dynamic masculinity performed in various public settings.
Teaching Local History Using Digital Humanities
Authors: Elliott Steven
Published: January 2021

This article shares lessons learned from teaching two related undergraduate courses, History of New Jersey and History of Newark, both at Rutgers University-Newark.  Students in these courses have completed several assignments that asked them to find and analyze primary sources using online databases and repositories.  I share an overview of the assignments, highlight students’ best finds in the course of their research, and assess what aspects of the assignments worked well and what needed improvement.  Overall, this article finds that online primary sources are ample and easily accessible, though their abundance means that students may need assistance in determining what will best fit their projects.
The Origins of Centenary Collegiate Institute: A Story of Industrialization, Wealth, and Natural Resources
Authors: Graham Sean
Published: January 2021

The Paul A. Stellhorn Undergraduate Paper in New Jersey History Award was established in 2004 to honor Paul A. Stellhorn (1947-2001), a distinguished historian and public servant who worked for the New Jersey Historical Commission, the New Jersey Committee (now Council) for the Humanities, and the Newark Public Library. The Stellhorn Awards consist of a framed certificate and a modest cash award, presented at the New Jersey Historical Commission’s Annual Conference.  The Award’s sponsors are the New Jersey Studies Academic Alliance; the New Jersey Historical Commission, New Jersey Department of State; Special Collections and University Archives, Rutgers University Libraries; and the New Jersey Caucus, Mid-Atlantic Regional Archives Conference.  The Stellhorn Award Committee members are Richard Waldron (chair), Mark Lender, and Peter Mickulas.  The advisory committee consists of Ron Becker, Karl Niederer, Elsalyn Palmisano, and Fred Pachman.  Click here for more information. The following paper was one of two 2020 winners.
Making the Scene in the Garden State: Popular Music in New Jersey from Edison to Springsteen and Beyond
Authors: Womack Kenneth
Published: January 2021

Making the Scene in the Garden State: Popular Music in New Jersey from Edison to Springsteen and Beyond, reviewed by Kenneth Womack
Ivana Bozděchová jubilující
Authors: Hasil Jiří
Published: January 2021

-
Vzpomínka na Stanislavu Kloferovou
Authors: Vojtová Jarmila
Published: January 2021

-
La interferencia entre marcas e indicaciones geográficas en el ámbito vitivinícola
Authors: Buggea Alessia
Published: January 2021

The judgment of the General Court of the European Union (Sixth Chamber), Case T 696/15 of 9 February 2017, against EUIPO examines, among the procedural aspects of the European trade mark regime, non-registration of a wine product in the event of non-compliance with the essential, in particular absolute, requirements for the acquisition of a mark in the territory of the European Union. In examining the various provisions at European level which provide for the granting or denial of trademarks and for the purpose of ensuring that geographical indications are fully effective in the European trade mark registration proceedings, this is to prevent holders from incurring any the grounds for annulment, Regulation Nº 207/2009 on the Community trade mark (hereinafter referred to as the CTMR), 7. 1, (j), points out that they are excluded from the register ‘wine marks containing or consisting of a geographical indication identifying wines, or marks of spirit drinks containing or consisting of a geographical indication identifying the spirits, where such wines or drinks do not have such origin’. The inadmissibility of the application for a word mark which contains a geographical indication which does not belong to it and also coincides with other appellations of origin is, inter alia, the central argument of the judicial issue under consideration. The legal question arose in 2014, when a Spanish mercantile company (Bodegas Vega Sicilia) decided to register the word mark “Tempos Vega Sicilia” before the EUIPO which, however, denied the registration of the same because it the term “Sicilia” is part of the protected designations of origin for wines. Hence, the mercantile company decided to appeal in 2015 to the EU General Court, which rejected the appeal by ruling of 9 February 2017, also rejecting, as the EUIPO did at the time, the arguments of the applicant relating to the existence of a family of registered trade marks prior to the registration of the DO or the potential popularity of said family of trademarks and guaranteeing maximum protection of protected geographical denominations and, therefore, denying registration when, when included in a trademark, it was not limited to the product of the said geographical area.
The benefits of remoteness – digital mobility data, regional road infrastructure, and COVID-19 infections
Authors: Krenz Astrid , Strulik Holger
Published: January 2021

We investigate the regional distribution of the COVID-19 outbreak in Germany. We use a novel digital mobility dataset, that traces the undertaken trips on Easter Sunday 2020 and instrument them with regional accessibility as measured by the regional road infrastructure of Germany’s 401 NUTS III regions. We identify a robust negative association between the number of infected cases per capita and average travel time on roads to the next major urban center. What has been a hinderance for economic performance in good economic times, appears to be a benevolent factor in the COVID-19 pandemic: bad road infrastructure. Using road infrastructure as an instrument for mobility reductions we assess the causal effect of mobility reductions on infections. The study shows that keeping mobility of people low is a main factor to reduce infections. Aggregating over all regions, our results suggest that there would have been about 55,600 infections less on May 5th, 2020, if mobility at the onset of the disease were 10 percent lower.
Reproducibility and efficiency in handling complex neurophysiological data
Authors: Denker Michael , Grün Sonja , Wachtler Thomas , Scherberger Hansjörg
Published: January 2021

Preparing a neurophysiological data set with the aim of sharing and publishing is hard. Many of the available tools and services to provide a smooth workflow for data publication are still in their maturing stages and not well integrated. Also, best practices and concrete examples of how to create a rigorous and complete package of an electrophysiology experiment are still lacking. Given the heterogeneity of the field, such unifying guidelines and processes can only be formulated together as a community effort. One of the goals of the NFDI-Neuro consortium initiative is to build such a community for systems and behavioral neuroscience. NFDI-Neuro aims to address the needs of the community to make data management easier and to tackle these challenges in collaboration with various international initiatives (e.g., INCF, EBRAINS). This will give scientists the opportunity to spend more time analyzing the wealth of electrophysiological data they leverage, rather than dealing with data formats and data integrity.
Artificial Neural Network Modelling of Multi-system Dynamic Adsorption of Organic Pollutants on Activated Carbon
Authors: Mesllem Yamin , Hentabli Mohamed , Hanini Salah , Laidi Maamar , Abdallah Abdallah El Hadj
Published: January 2021

The aim of this work was to model multi-system dynamic adsorption using an artificial intelligence technique. A set of data points, collected from scientific papers containing the dynamic adsorption kinetics on activated carbon, was used to build the artificial neural network (ANN). The studied parameters were molar mass, initial concentration, flow rate, bed height, particle diameter, BET surface area, average pore diameter, time, and concentration of dimensionless effluents. Results showed that the optimized ANN was obtained with a high correlation coefficient, R = 0.997, a root mean square error of RMSE = 0.029, and a mean absolute deviation of AAD (%) = 1.810 during the generalisation phase. Furthermore, a sensitivity analysis was also conducted using the inverse artificial neural network method to study the effect of all the inputs on the dynamic adsorption. Also in this work, the traceability of the estimated results was conducted by developing a graphical user interface.
Utjecaj dugolančanog i razgranatog alkohola na mazivost estera na bazi dodekandiojske kiseline
Authors: Ahmed Waled Abdo , Yousif Emad , Al-mashhadani Mohammed H. , Yarmo Mohd Ambar , Salih Nadia , Salimon Jumat
Published: January 2021

Thirteen samples of esters based on dodecanedioic acid with different chemical structures were synthesized. Among these were di-2-octyl dodecanedioate, didecyl dodecanedioate, di-2-ethylhexanol dodecanedioate, di-2-ethylbutyl dodecanedioate, dioctyl dodecanedioate, dihexyl dodecanedioate, and dioleyl dodecanedioate. Diesters were synthesized through the esterification of dodecanedioic acid with selected long-chain and branched alcohols with acid catalyst of H2SO4. These esters were tested in terms of their suitability for application as lubricants. The results showed that the lubricity properties, based on their pour point, flash point, and oxidation stability of the esters were significantly affected by the linear and branched alcohols used. An excellent pour point property of di-2-ethylbutyl dodecanedioate and di-2-ethylhexanol dodecanedioate at −55 °C and −50 °C was observed compared to their respective same linear carbon number esters of dihexyl dodecanedioate at 10 °C and dioctyl dodecanedioate at 20 °C. These are due to the presence of the branched group in their molecule vicinity structure. However, the esters flash points were insignificantly affected by the presence of branched structure. The selected esters could be used for biolubricants or engine oil.
Subdivision of joint tenure in agricultural communities: customary land rights management in Slovenia
Authors: Čeh Marjan , Žužel Helena , Mansutti Simon
Published: January 2021

This paper presents the process of real estate reallocation as a mass cadastral subdivision process of agrarian communities’ customary rights. The agricultural communities have existed for centuries and have been jointly owning and using the common land. Such gatherings were developed mainly due to the unique requirements deriving from land use and relief characteristics, such as joint forest management on mountain slopes. The main objective of this research has been to analyse the process of real estate subdivision, which has its legal background in Slovenian legislation. In this paper, the process of cadastral subdivision of land owned by agricultural communities is presented as a mass cadastral land subdivision process: from preparatory work to the new geometric structure of the common land. The cadastral, organisational, and engineering role of the chartered surveying engineer and the surveying company is examined. An aim of the paper is, inter alia, to develop a conceptual model of the process that will serve as a basis for optimisation, for a more just and more efficient distribution of assets among community members. The course of the individual steps of the community established land subdivision is shown with unified modelling language (UML) activity diagrams. As a case study, we have considered the subdivision of the property of the agricultural community of Zgornja Sorica in Slovenia.
Automatic building footprint extraction from UAV images using neural networks
Authors: Kokeza Zoran , Vujasinović Miroslav , Govedarica Miro , Milojević Brankica , Jakovljević Gordana
Published: January 2021

Up-to-date cadastral maps are crucial for urban planning. Creating those maps with the classical geodetic methods is expensive and time-consuming. Emerge of Unmanned Aerial Vehicles (UAV) made a possibility for quick acquisition of data with much more details than it was possible before. The topic of the research refers to the challenges of automatic extraction of building footprints on high-resolution orthophotos. The objectives of this study were as follows: (1) to test the possibility of using different publicly available datasets (Tanzania, AIRS and Inria) for neural network training and then test the generalisation capability of the model on the Area Of Interest (AOI); (2) to evaluate the effect of the normalised digital surface model (nDSM) on the results of neural network training and implementation. Evaluation of the results shown that the models trained on the Tanzania (IoU 36.4%), AIRS (IoU 64.4%) and Inria (IoU 7.4%) datasets doesn't satisfy the requested accuracy to update cadastral maps in study area. Much better results are achieved in the second part of the study, where the training of the neural network was done on tiles (256x256) of the orthophoto of AOI created from data acquired using UAV. A combination of RGB orthophoto with nDSM resulted in a 2% increase of IoU, achieving the final IoU of over 90%.