bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S1 from Interim Phase II Results Using Panitumumab-IRDye800CW during Transoral Robotic Surgery in Patients with Oropharyngeal Cancer
Authors: Stone Logan D. , Kasten Benjamin B. , Rao Shilpa , Gonzalez Manuel. L. , Stevens Todd M. , Lin Diana , Carroll William , Greene Benjamin , Moore Lindsay S. , Fuson Andrew , James Sherin , Hartman Yolanda E. , McCammon Susan , Panuganti Bharat , Nabell Lisle M. , Li Yufeng , Li Mei , Bailey Luke , Rosenthal Eben L. , Jeyarajan Harishanker , Thomas Carissa M. , Warram Jason M.
Published: September 2024

Supplementary Figure S1: OPSCC EGFR H-scores.
Figure S4 from Overcoming Osimertinib Resistance with AKT Inhibition in EGFRm-Driven Non–Small Cell Lung Cancer with PIK3CA/PTEN Alterations
Authors: Grazini Ursula , Markovets Aleksandra , Ireland Lucy , O’Neill Daniel , Phillips Benjamin , Xu Man , Pfeifer Matthias , Vaclova Tereza , Martin Matthew J. , Bigot Ludovic , Friboulet Luc , Hartmaier Ryan , Cuomo Maria E. , Barry Simon T. , Smith Paul D. , Floc’h Nicolas
Published: September 2024

Figure S4: In PC9 PIK3CAm xenograft models osimertinib induced diminished on-treatment tumor regression compared with parental PC9 xenograft models.
Figure S2 from Overcoming Osimertinib Resistance with AKT Inhibition in EGFRm-Driven Non–Small Cell Lung Cancer with PIK3CA/PTEN Alterations
Authors: Grazini Ursula , Markovets Aleksandra , Ireland Lucy , O’Neill Daniel , Phillips Benjamin , Xu Man , Pfeifer Matthias , Vaclova Tereza , Martin Matthew J. , Bigot Ludovic , Friboulet Luc , Hartmaier Ryan , Cuomo Maria E. , Barry Simon T. , Smith Paul D. , Floc’h Nicolas
Published: September 2024

Figure S2: EGFRm NSCLC cells with PIK3CA GOF and PTEN LOF mutations show resistant to osimertinib and can be resensitized by co-treatment with the AKT inhibitor capivasertib (AZD5363).
Supplementary Table S2 from Circulating Tumor DNA Assessment for Treatment Monitoring Adds Value to PSA in Metastatic Castration-Resistant Prostate Cancer
Authors: Sweeney Christopher J. , Petry Russell , Xu Chang , Childress Merrida , He Jie , Fabrizio David , Gjoerup Ole , Morley Samantha , Catlett Timothy , Assaf Zoe J. , Yuen Kobe , Wongchenko Matthew , Shah Kalpit , Gupta Pratyush , Hegde Priti , Pasquina Lincoln W. , Mariathasan Sanjeev , Graf Ryon P. , Powles Thomas
Published: September 2024

Patient characteristics of the biomarker evaluable population (BEP) cohort
Supplementary Figure S1 from Reconstitution of the Multiple Myeloma Microenvironment Following Lymphodepletion with BCMA CAR-T Therapy
Authors: Yang Yazi , Qin Sen , Yang Mengyu , Wang Ting , Feng Ru , Zhang Chunli , Zheng Enrun , Li Qinghua , Xiang Pengyu , Ning Shangyong , Xu Xiaodong , Zuo Xin , Zhang Shuai , Yun Xiaoya , Zhou Xuehong , Wang Yue , He Lin , Shang Yongfeng , Sun Luyang , Liu Hui
Published: September 2024

Supplementary Figure S1. Quality Control of the scRNA-seq Data.
Table S1 from Oral and Gut Microbiome Alterations in Oral Chronic GVHD Disease: Results from Close Assessment and Testing for Chronic GVHD (CATCH Study)
Authors: Rashidi Armin , Pidala Joseph , Hamilton Betty K. , Pavletic Steven Z. , Kim Katie , Zevin Alex , Mays Jacqueline W. , Lee Stephanie J.
Published: September 2024

Study population representativeness
Supplementary Figure S6 from Phase II Trial of HER-Vaxx, a B-cell Peptide-Based Vaccine, in HER2-Overexpressing Advanced Gastric Cancer Patients Under Platinum-Based Chemotherapy (HERIZON)
Authors: Tobias Joshua , Maglakelidze Marina , Andrić Zoran , Ryspayeva Dinara , Bulat Iurie , Nikolić Ivan , Petrović Zoran , Chawla Tanuj , Nagarkar Rajnish , Garner-Spitzer Erika , Zielinski Christoph C. , Chong Leslie Mi Ok , Nixon Bonnie , Ede Nicholas J. , Yavrom Sharon , Kundi Michael , Wiedermann Ursula
Published: September 2024

Supplementary Figure S6. Comparison of HER2-specific total IgG antibody levels in the patients vaccinated with 50-µg and 100 µg of HER-Vaxx plus chemotherapy.
Supplementary Table 1 from Precision Oncology and Systemic Targeted Therapy in Pseudomyxoma Peritonei
Authors: Martínez-Quintanilla Jordi , Cabot Débora , Sabia Doménico , Arqués Oriol , Vergés Jordi , Chicote Irene , Bijelic Lana , Cabellos Laia , Alcántara Anna M. , Ramos Isabel , Barrios Pedro , Crusellas Oriol , Palacio Lina M. , Cámara Juan A. , Barriuso Jorge , Jiménez Juan J. , Muñoz-Torres Pau , Nonell Lara , Flores Raquel , Médico Enzo , Guaglio Marcello , Ros Javier , Élez Elena , Tabernero Josep , Aziz Omer , Deraco Marcello , Palmer Héctor G. , Giovanna Chiorino , Francesco Mazzarotto , Manuela Gariboldi , Luca Varinelli , Tommaso Cavalleri , Bipasha Chakrabarty , Raghavendar Nagaraju , Patrick Caswell , Milly McAllister
Published: September 2024

Supplementary Table 1. Primary and secondary antibodies, commercial provider, reference, and dilution used for WB or IHC.
Supplementary Figure 4 from Precision Oncology and Systemic Targeted Therapy in Pseudomyxoma Peritonei
Authors: Martínez-Quintanilla Jordi , Cabot Débora , Sabia Doménico , Arqués Oriol , Vergés Jordi , Chicote Irene , Bijelic Lana , Cabellos Laia , Alcántara Anna M. , Ramos Isabel , Barrios Pedro , Crusellas Oriol , Palacio Lina M. , Cámara Juan A. , Barriuso Jorge , Jiménez Juan J. , Muñoz-Torres Pau , Nonell Lara , Flores Raquel , Médico Enzo , Guaglio Marcello , Ros Javier , Élez Elena , Tabernero Josep , Aziz Omer , Deraco Marcello , Palmer Héctor G. , Giovanna Chiorino , Francesco Mazzarotto , Manuela Gariboldi , Luca Varinelli , Tommaso Cavalleri , Bipasha Chakrabarty , Raghavendar Nagaraju , Patrick Caswell , Milly McAllister
Published: September 2024

Supplementary Figure 4. BRAF inhibitor reduces Phospho-ERK in BRAFV600E mutant PMPPDO and PDXO models in a dose dependent manner.
Supplementary Figure 2 from Precision Oncology and Systemic Targeted Therapy in Pseudomyxoma Peritonei
Authors: Martínez-Quintanilla Jordi , Cabot Débora , Sabia Doménico , Arqués Oriol , Vergés Jordi , Chicote Irene , Bijelic Lana , Cabellos Laia , Alcántara Anna M. , Ramos Isabel , Barrios Pedro , Crusellas Oriol , Palacio Lina M. , Cámara Juan A. , Barriuso Jorge , Jiménez Juan J. , Muñoz-Torres Pau , Nonell Lara , Flores Raquel , Médico Enzo , Guaglio Marcello , Ros Javier , Élez Elena , Tabernero Josep , Aziz Omer , Deraco Marcello , Palmer Héctor G. , Giovanna Chiorino , Francesco Mazzarotto , Manuela Gariboldi , Luca Varinelli , Tommaso Cavalleri , Bipasha Chakrabarty , Raghavendar Nagaraju , Patrick Caswell , Milly McAllister
Published: September 2024

Supplementary Figure 2. PMP-PDX models resemble histological features of the original patient sample with massive mucinous secretion and preserve invasiveness.
Data from Overcoming Osimertinib Resistance with AKT Inhibition in EGFRm-Driven Non–Small Cell Lung Cancer with PIK3CA/PTEN Alterations
Authors: Grazini Ursula , Markovets Aleksandra , Ireland Lucy , O’Neill Daniel , Phillips Benjamin , Xu Man , Pfeifer Matthias , Vaclova Tereza , Martin Matthew J. , Bigot Ludovic , Friboulet Luc , Hartmaier Ryan , Cuomo Maria E. , Barry Simon T. , Smith Paul D. , Floc’h Nicolas
Published: September 2024

AbstractPurpose:
Osimertinib is an EGFR tyrosine kinase inhibitor indicated for the treatment of EGFR-mutated (EGFRm)–driven lung adenocarcinomas. Osimertinib significantly improves progression-free survival in first-line–treated patients with EGFRm advanced non–small cell lung cancer (NSCLC). Despite the durable disease control, the majority of patients receiving osimertinib eventually develop disease progression.
Experimental Design:
ctDNA profiling analysis of on-progression plasma samples from patients treated with osimertinib in both first- (phase III, FLAURA trial) and second-line trials (phase III, AURA3 trial) revealed a high prevalence of PIK3CA/AKT/PTEN alterations. In vitro and in vivo evidence using CRISPR-engineered NSCLC cell lines and patient-derived xenograft (PDX) models supports a functional role for PIK3CA and PTEN mutations in the development of osimertinib resistance.
Results:
These alterations are functionally relevant as EGFRm NSCLC cells with engineered PIK3CA/AKT/PTEN alterations develop resistance to osimertinib and can be resensitized by treatment with the combination of osimertinib and the AKT inhibitor capivasertib. Moreover, xenograft and PDX in vivo models with PIK3CA/AKT/PTEN alterations display limited sensitivity to osimertinib relative to models without alterations, and in these double-mutant models, capivasertib and osimertinib combination elicits an improved antitumor effect versus osimertinib alone.
Conclusions:
Together, this approach offers a potential treatment strategy for patients with EGFRm-driven NSCLC who have a suboptimal response or develop resistance to osimertinib through PIK3CA/AKT/PTEN alterations.

See related commentary by Vokes et al., p. 3968
Data from Precision Oncology and Systemic Targeted Therapy in Pseudomyxoma Peritonei
Authors: Martínez-Quintanilla Jordi , Cabot Débora , Sabia Doménico , Arqués Oriol , Vergés Jordi , Chicote Irene , Bijelic Lana , Cabellos Laia , Alcántara Anna M. , Ramos Isabel , Barrios Pedro , Crusellas Oriol , Palacio Lina M. , Cámara Juan A. , Barriuso Jorge , Jiménez Juan J. , Muñoz-Torres Pau , Nonell Lara , Flores Raquel , Médico Enzo , Guaglio Marcello , Ros Javier , Élez Elena , Tabernero Josep , Aziz Omer , Deraco Marcello , Palmer Héctor G. , Giovanna Chiorino , Francesco Mazzarotto , Manuela Gariboldi , Luca Varinelli , Tommaso Cavalleri , Bipasha Chakrabarty , Raghavendar Nagaraju , Patrick Caswell , Milly McAllister
Published: September 2024

AbstractPurpose:
Pseudomyxoma peritonei (PMP) is a rare and poorly understood malignant condition characterized by the accumulation of intra-abdominal mucin produced from peritoneal metastases. Currently, cytoreductive surgery remains the mainstay of treatment but disease recurrence and death after relapse frequently occur in patients with PMP. New therapeutic strategies are therefore urgently needed for these patients.
Experimental Design:
A total of 120 PMP samples from 50 patients were processed to generate a collection of 50 patient-derived organoid (PDO) and xenograft (PDX) models. Whole exome sequencing, immunohistochemistry analyses, and in vitro and in vivo drug efficacy studies were performed.
Results:
In this study, we have generated a collection of PMP preclinical models and identified druggable targets, including BRAFV600E, KRASG12C, and KRASG12D, that could also be detected in intra-abdominal mucin biopsies of patients with PMP using droplet digital PCR. Preclinical models preserved the histopathological markers from the original patient sample. The BRAFV600E inhibitor encorafenib reduced cell viability of BRAFV600E PMP-PDO models. Proof-of-concept in vivo experiments showed that a systemic treatment with encorafenib significantly reduced tumor growth and prolonged survival in subcutaneous and orthotopic BRAFV600E-PMP-PDX mouse models.
Conclusions:
Our study demonstrates for the first time that systemic targeted therapies can effectively control PMP tumors. BRAF signaling pathway inhibition represents a new therapeutic opportunity for patients with BRAFV600E PMP who have a poor prognosis. Importantly, our present data and collection of preclinical models pave the way for evaluating the efficacy of other systemic targeted therapies toward extending the promise of precision oncology to patients with PMP.
Table 2 from ORIC-101, a Glucocorticoid Receptor Antagonist, in Combination with Nab-Paclitaxel in Patients with Advanced Solid Tumors
Authors: Chen Christopher T. , Khanna Vishesh , Kummar Shivaani , Abdul-Karim Raghad M. , Sommerhalder David , Tolcher Anthony W. , Ueno Naoto T. , Davis Sarah Lindsey , Orr Douglas W. , Hamilton Erika , Patel Manish R. , Spira Alexander I. , Jauhari Shekeab , Florou Vaia , Duff Maureen , Xu Rongda , Wang Jian , Barkund Shravani R. , Zhou Haiying , Pankov Aleksandr , Kong Wayne , Jahchan Nadine S. , Jackson Erica L. , Sun Jessica D. , Junttila Melissa R. , Multani Pratik S. , Daemen Anneleen , Chow Maneval Edna , Munster Pamela N.
Published: September 2024

TRAEs occurring in at least 10% of dose expansion patients or grade 3 in severity treated at the RP2D
Figure S4 from Putrescine Supplementation Limits the Expansion of pks+ Escherichia coli and Tumor Development in the Colon
Authors: Oliero Manon , Cuisiniere Thibault , Ajayi Ayodeji S. , Gerkins Claire , Hajjar Roy , Fragoso Gabriela , Calvé Annie , Vennin Rendos Hervé , Mathieu-Denoncourt Annabelle , Dagbert François , De Broux Éric , Loungnarath Rasmy , Schwenter Frank , Sebajang Herawaty , Ratelle Richard , Wassef Ramses , Richard Carole , Duperthuy Marylise , Gravel Andrée E. , Vincent Antony T. , Santos Manuela M.
Published: September 2024

Figure S4 shows gut microbiota changes after DSS-induced flares
Supplementary Table 3 from Tumor-Immune Signatures of Treatment Resistance to Brentuximab Vedotin with Ipilimumab and/or Nivolumab in Hodgkin Lymphoma
Authors: Gonzalez-Kozlova Edgar , Huang Hsin-Hui , Jagede Opeyemi A. , Tuballes Kevin , Del Valle Diane M. , Kelly Geoffrey , Patel Manishkumar , Xie Hui , Harris Jocelyn , Argueta Kimberly , Nie Kai , Barcessat Vanessa , Moravec Radim , Altreuter Jennifer , Duose Dzifa Y. , Kahl Brad S. , Ansell Stephen M. , Yu Joyce , Cerami Ethan , Lindsay James R. , Wistuba Ignacio I. , Kim-Schulze Seunghee , Diefenbach Catherine S. , Gnjatic Sacha
Published: September 2024

OS Multivariate analysis showing that markers significant during univariate analysis are not significant during multivariate analysis.
Supplementary Table 4 from Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures
Authors: Mahmood Umair , Blake Andrew , Rathee Sanjay , Samuel Leslie , Murray Graeme , Sebag-Montefiore David , Gollins Simon , West Nicholas P. , Begum Rubina , Bach Simon P. , Richman Susan D. , Quirke Phil , Redmond Keara L. , Salto-Tellez Manuel , Koelzer Viktor H. , Leedham Simon J. , Tomlinson Ian , Dunne Philip D. , Buffa Francesca M. , Maughan Tim S. , Domingo Enric
Published: September 2024

Supplementary Table 4
Supplementary Material from Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures
Authors: Mahmood Umair , Blake Andrew , Rathee Sanjay , Samuel Leslie , Murray Graeme , Sebag-Montefiore David , Gollins Simon , West Nicholas P. , Begum Rubina , Bach Simon P. , Richman Susan D. , Quirke Phil , Redmond Keara L. , Salto-Tellez Manuel , Koelzer Viktor H. , Leedham Simon J. , Tomlinson Ian , Dunne Philip D. , Buffa Francesca M. , Maughan Tim S. , Domingo Enric
Published: September 2024

Supplementary Material
Supplementary Figure 2 from Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures
Authors: Mahmood Umair , Blake Andrew , Rathee Sanjay , Samuel Leslie , Murray Graeme , Sebag-Montefiore David , Gollins Simon , West Nicholas P. , Begum Rubina , Bach Simon P. , Richman Susan D. , Quirke Phil , Redmond Keara L. , Salto-Tellez Manuel , Koelzer Viktor H. , Leedham Simon J. , Tomlinson Ian , Dunne Philip D. , Buffa Francesca M. , Maughan Tim S. , Domingo Enric
Published: September 2024

Supplementary Figure 2
Data from Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures
Authors: Mahmood Umair , Blake Andrew , Rathee Sanjay , Samuel Leslie , Murray Graeme , Sebag-Montefiore David , Gollins Simon , West Nicholas P. , Begum Rubina , Bach Simon P. , Richman Susan D. , Quirke Phil , Redmond Keara L. , Salto-Tellez Manuel , Koelzer Viktor H. , Leedham Simon J. , Tomlinson Ian , Dunne Philip D. , Buffa Francesca M. , Maughan Tim S. , Domingo Enric
Published: September 2024

Abstract
Response to neoadjuvant radiotherapy (RT) in rectal cancer has been associated with immune and stromal features that are captured by transcriptional signatures. However, how such associations perform across different chemoradiotherapy regimens and within individual consensus molecular subtypes (CMS) and how they affect survival remain unclear. In this study, gene expression and clinical data of pretreatment biopsies from nine cohorts of primary rectal tumors were combined (N = 826). Exploratory analyses were done with transcriptomic signatures for the endpoint of pathologic complete response (pCR), considering treatment regimen or CMS subtype. Relevant findings were tested for overall survival and recurrence-free survival. Immune and stromal signatures were strongly associated with pCR and lack of pCR, respectively, in RT and capecitabine (Cap)/5-fluorouracil (5FU)–treated patients (N = 387), in which the radiosensitivity signature (RSS) showed the strongest association. Upon addition of oxaliplatin (Ox; N = 123), stromal signatures switched direction and showed higher chances to achieve pCR than without Ox (p for interaction 0.02). Among Cap/5FU patients, most signatures performed similarly across CMS subtypes, except cytotoxic lymphocytes that were associated with pCR in CMS1 and CMS4 cases compared with other CMS subtypes (p for interaction 0.04). The only variables associated with survival were pCR and RSS. Although the frequency of pCR across different chemoradiation regimens is relatively similar, our data suggest that response rates may differ depending on the biological landscape of rectal cancer. Response to neoadjuvant RT in stroma-rich tumors may potentially be improved by the addition of Ox. RSS in preoperative biopsies provides predictive information for response specifically to neoadjuvant RT with 5FU.
Significance:
Rectal cancers with stromal features may respond better to RT and 5FU/Cap with the addition of Ox. Within patients not treated with Ox, high levels of cytotoxic lymphocytes associate with response only in immune and stromal tumors. Our analyses provide biological insights about the outcome by different radiotherapy regimens in rectal cancer.
Record-Breaking Marine Heatwave over the Central North Pacific in 2021 Summer: Its Formation Associated with Loss of Central Mode Water
Authors: Nishihira Gaku , Sugimoto Shusaku
Published: September 2024

Marine heatwaves (MHWs) are prolonged extremely high sea surface temperature (SST) events. In the 2021 summer, an intense MHW occurred over the central North Pacific; the SST in September 2021 was the highest in September since 1900, and the warming signal was distributed not only near the sea surface but also below the ocean mixed layer (∼300-m depth). Atmosphere reanalysis data showed westward expansion of the North Pacific subtropical high (NPSH) in the 2021 summer, but both an increase in downward shortwave radiation and a decrease in upward latent heat flux were not so large, and ocean mixed layer heat budget analysis, which also used ocean reanalysis data, revealed that the atmosphere-induced heating is insufficient to form the record-breaking MHW. Argo profiling floats indicated that, in the 2021 summer, the Central Mode Water (CMW)—a huge water mass characterized by vertically uniform properties in depths of 100–500 m—decreased extremely, the thickness of which was less than 20% of the normal. Statistical analysis showed that, from the sea surface to the upper boundary of CMW, the heavier isopycnal surfaces are deeper associated with the decrease in CMW, leading to a weakening of the seasonal pycnocline. Then, this causes the weakening of cooling heat flux associated with the entrainment of subsurface waters into the mixed layer, resulting in surface ocean warming, which in turn contributed to form the MHW in the 2021 summer.
Comparative effectiveness and safety of eplerenone and spironolactone in patients with heart failure: a systematic review and meta-analysis
Authors: Elshahat Ahmed , Mansour Ahmed , Ellabban Mohamed , Diaa Ahmed , Hassan Atef , Fawzy Ahmed , Saad Omar Abdulrahman , Abouelmagd Moaz , Eid Mahmoud , Elaraby Ahmed , Elkasaby Mohamed Hamouda , Abdelaziz Ahmed
Published: September 2024

Background

Eplerenone and spironolactone, recognized as mineralocorticoid receptor antagonists (MRAs), have been reported to improve clinical prognosis among individuals diagnosed with heart failure (HF). However, the difference in the clinical effects between eplerenone and spironolactone in individuals with HF remains uncertain. We aimed to assess the impact of eplerenone compared to spironolactone on clinical outcomes within the HF population.

Methods

An extensive search was executed in several databases (PubMed, Web of Science, Scopus, Cochrane Library). All relevant studies evaluating eplerenone compared to spironolactone in patients with HF were included. Dichotomous data were pooled as Hazard ratio (HR) or Risk ratio (RR) with a 95% confidence interval (CI). Our main outcome was all-cause mortality. Secondary outcomes included death from cardiovascular causes, treatment withdrawal, and gynecomastia.

Results

Ten studies, comprising 21,930 HF individuals, were included in our investigation. Eplerenone showed a lower risk of all-cause mortality (HR = 0.78, 95%CI [0.64 to 0.94], P = 0.009) and cardiovascular mortality (HR = 0.54, 95%CI [0.39, 0.74], P = 0.0001) compared to spironolactone. Furthermore, eplerenone exhibited a reduced risk of treatment withdrawal (RR = 0.69, 95% CI [0.62, 0.78], P = 0.0001) and gynecomastia (RR = 0.07, 95% CI [0.02 to 0.31], P = 0.0001) than spironolactone.

Conclusion

Eplerenone revealed lower all-cause and cardiovascular mortality events in comparison to spironolactone. Moreover, eplerenone was associated with lower gynecomastia and treatment withdrawal events compared to spironolactone. Further well-designed randomized controlled trials are still warranted better to identify the clinical differences between eplerenone and spironolactone.

Trial registration

Protocol registration: https://doi.org/10.17605/OSF.IO/VNMGK
Perceived outcomes of medical teaching institute reforms: insights from management, faculty, and administration in Pakistani tertiary health care
Authors: Qamar Wajiha , Qayum Mehran , Nisa Waqar-un , Ali Asma
Published: September 2024

Objective

The study aims to explore the perceived outcomes of Medical Teaching Institution (MTI) reforms on autonomy and overall performance within tertiary healthcare institutions in Khyber Pakhtunkhwa (KP) province, Pakistan.

Methodology

A cross-sectional study was carried out from September 2023 to March 2024, involving interviews with frontline staff, administrative personnel, and senior management within MTI-affiliated institutions. The methodology employed, using both qualitative and quantitative data analysis techniques.

Results

The study showed that institutional staff members’ knowledge and understanding of the MTI changes differed. Some observed very minor adjustments, while others saw advances in hospital operations and service delivery. Administrative complexity, political meddling, and resource allocation problems were noted as challenges. Positive results were also observed, though, and they included improved infrastructure, possibilities for staff training, and decision-making procedures.

Conclusion

Despite significant improved, there are still challenges, such as inconsistent staff comprehension, mixed impacts on service delivery, resource allocation issues, and political meddling. Addressing these issues necessitates improved communication, continuous evaluation, and coordinated efforts to improve administrative systems and obtain consistent funding.
Prevalence, risk factors, and characterisation of extended-spectrum β-lactamase -producing Enterobacterales (ESBL-E) in horses entering an equine hospital and description of longitudinal excretion
Authors: Eskola Katarina , Aimo-Koivisto Elina , Heikinheimo Annamari , Mykkänen Anna , Hautajärvi Tiina , Grönthal Thomas
Published: September 2024

Background

Extended-spectrum β-lactamase -producing Enterobacterales (ESBL-E) are important zoonotic pathogens that can cause serious clinical infections, also in horses. Preventing the spread of ESBL-E, especially in the equine hospital environment, is key to reducing the number of difficult-to-treat infections. Estimating the local prevalence of ESBL-E in horses is crucial to establish targeted infection control programs at equine hospitals. We conducted a prevalence and risk factor study in equine patients on admission to an equine teaching hospital in Finland through a rectal ESBL-E screening specimen of the horse and a questionnaire.

Results

The prevalence of ESBL-E in admitted horses was 3% (5/161, 95% CI 1–7%); none of the tested factors remained statistically significant in multivariate analysis, although antimicrobial treatment within three months was borderline significant (p = 0.052). Extended-spectrum β-lactamase -producing Klebsiella pneumoniae ST6179:CTX-M-15 was detected in three horses using whole-genome sequencing, which in combination with patient records suggested nosocomial transmission. Escherichia coli isolates were ST1250:CTX-M-1 (n = 1), ST1079:CTX-M-1 (n = 1), and ST1245:CTX-M-14 (n = 1). Multiple virulence genes were detected in the ESBL-E isolates. In the ESBL-E positive horses enrolled in a one-year follow-up study, ESBL-E were unlikely to be isolated in rectal screening specimens after the initial positive specimen.

Conclusions

The prevalence of ESBL-E in horses visiting a veterinary teaching hospital in Finland is low, indicating an overall low prevalence estimate in the country’s equine population. No statistically significant risk factors were identified, likely due to the low number of cases. The duration of ESBL-E carriage is likely to be very short in horses.
Glucose metabolism in glioma: an emerging sight with ncRNAs
Authors: Rong Jun , Wang Qifu , Li Tingzheng , Qian Jin , Cheng Jinchao
Published: September 2024

Glioma is a primary brain tumor that grows quickly, has an unfavorable prognosis, and can spread intracerebrally. Glioma cells rely on glucose as the major energy source, and glycolysis plays a critical role in tumorigenesis and progression. Substrate utilization shifts throughout glioma progression to facilitate energy generation and biomass accumulation. This metabolic reprogramming promotes glioma cell proliferation and metastasis and ultimately decreases the efficacy of conventional treatments. Non-coding RNAs (ncRNAs) are involved in several glucose metabolism pathways during tumor initiation and progression. These RNAs influence cell viability and glucose metabolism by modulating the expression of key genes of the glycolytic pathway. They can directly or indirectly affect glycolysis in glioma cells by influencing the transcription and post-transcriptional regulation of oncogenes and suppressor genes. In this review, we discussed the role of ncRNAs in the metabolic reprogramming of glioma cells and tumor microenvironments and their abnormal expression in the glucometabolic pathway in glioma. In addition, we consolidated the existing theoretical knowledge to facilitate the use of this emerging class of biomarkers as biological indicators and potential therapeutic targets for glioma.
Thromboelastography as an early prediction method for hypofibrinogenemia in emergency department patients with primary postpartum hemorrhage
Authors: Kim Sang-Min , Sohn Chang Hwan , Kwon Hyojeong , Ryoo Seung Mok , Ahn Shin , Seo Dong Woo , Kim Won Young
Published: September 2024

Background

Timely and accurate assessment of coagulopathy is crucial for the management of primary postpartum hemorrhage (PPH). Thromboelastography (TEG) provides a comprehensive assessment of coagulation status and is useful for guiding the treatment of hemorrhagic events in various diseases. This study aimed to evaluate the role of TEG in predicting hypofibrinogenemia in emergency department (ED) patients with primary PPH.

Methods

We conducted a retrospective observational study in the ED of a university-affiliated tertiary hospital between November 2015 and August 2023. TEG was performed upon admission. The cutoff value for hypofibrinogenemia was 200 mg/dL. The primary outcome was the presence of hypofibrinogenemia.

Results

Among the 174 patients, 73 (42.0%) had hypofibrinogenemia. The need for massive transfusion was higher in the hypofibrinogenemia group (37.0% vs. 5.0%, p < 0.001). Among the TEG parameters, all values were significantly different between the groups, except for lysis after 30 min, suggesting a tendency toward hypocoagulability. Multivariable analysis revealed that the alpha angle (odds ratio (OR) 0.924, 95% confidence interval (CI) 0.876–0.978) and maximum amplitude (MA) (OR 0.867, 95% CI 0.801–0.938) were independently associated with hypofibrinogenemia. The optimal cutoff values for the alpha angle and maximum amplitude (MA) for hypofibrinogenemia were 63.8 degrees and 56.1 mm, respectively.

Conclusion

Point-of-care TEG could be a valuable tool for the early identification of hypofibrinogenemia in ED patients with primary PPH.
Altered microRNA composition in the uterine lumen fluid in cattle (Bos taurus) pregnancies initiated by artificial insemination or transfer of an in vitro produced embryo
Authors: Biase Fernando H. , Moorey Sarah E. , Schnuelle Julie G. , Rodning Soren , Ortega Martha Sofia , Spencer Thomas E.
Published: September 2024

Background

MicroRNAs (miRNAs) are presented in the uterine lumen of many mammals, and in vitro experiments have determined that several miRNAs are important for the regulation of endometrial and trophoblast functions. Our aim was to identify and contrast the miRNAs present in extracellular vesicles (EVs) in the uterine lumen fluid (ULF) at the onset of attachment in cattle pregnancies (gestation d 18) initiated by artificial insemination (AI) or by the transfer of an in vitro-produced blastocyst (IVP-ET). A third group had no conceptus after the transfer of an IVP embryo.

Results

The abundance of 263 annotated miRNAs was quantified in the EVs collected from ULF. There was an increase in the transcript abundance of 20 miRNAs in the ULF EVs from the AI pregnant group, while 4 miRNAs had a lower abundance relative to the group not containing a conceptus. Additionally, 4 miRNAs were more abundant in ULF EVs in the AI pregnant group relative to IVP-ET group (bta-mir-17, bta-mir-7-3, MIR7-1, MIR18A). Specific miRNAs in the ULF EVs were co-expressed with messenger RNAs expressed in extra-embryonic tissues and endometrium, including genes that are known to be their targets.

Conclusions

The results provide biological insights into the participation of miRNAs in the regulation of trophoblast proliferation and differentiation, as well as in endometrium receptivity. The knowledge that in vitro cultured embryos can contribute to the altered abundance of specific miRNAs in the uterine lumen can lead to the development of corrective approaches to reduce conceptus losses during the first month of pregnancy in cattle.
A New Ultrasound-Guided, One-Point, Single Interfascial Plane Botulinum Toxin A Injection Technique for the Repair of Ventral Abdominal Wall Hernias Before Surgery: A Case Report
Authors: Hussain Altaf , Aldohayan Abdullah , Alsubae Khalid Abdullah , Ahmad Syed Anis , Altaf Muhammad Yousuf , Altaf Muhammad Musab , Aljomah Nadia Abdulaziz
Published: September 2024

Patients presenting with large ventral abdominal wall hernias require pretreatment with injection botulinum toxin A before surgery. Currently, multipoint and multilayered botulinum injection techniques are practiced. We are describing a new ultrasound-guided, 1-point, single interfascial plane botulinum toxin A injection technique for the closure of big hernial defects.
Molecular regulation of axon termination in mechanosensory neurons
Authors: Desbois Muriel , Grill Brock
Published: September 2024

Spatially and temporally accurate termination of axon outgrowth, a process called axon termination, is required for efficient, precise nervous system construction and wiring. The mechanosensory neurons that sense low-threshold mechanical stimulation or gentle touch have proven exceptionally valuable for studying axon termination over the past 40 years. In this Review, we discuss progress made in deciphering the molecular and genetic mechanisms that govern axon termination in touch receptor neurons. Findings across model organisms, including Caenorhabditis elegans, Drosophila, zebrafish and mice, have revealed that complex signaling is required for termination with conserved principles and players beginning to surface. A key emerging theme is that axon termination is mediated by complex signaling networks that include ubiquitin ligase signaling hubs, kinase cascades, transcription factors, guidance/adhesion receptors and growth factors. Here, we begin a discussion about how these signaling networks could represent termination codes that trigger cessation of axon outgrowth in different species and types of mechanosensory neurons.
Σημείωση στη μετάφραση του "Υπομνήματος στα Δεδομένα του Ευκλείδη" του Μαρίνου του Νεαπολίτη
Authors: Σιάλαρος Μιχάλης
Published: September 2024

Το 1896, δημοσιεύεται από τον Heinrich Menge η κριτική έκδοση και η λατινική μετάφραση του Υπομνήματος στα Δεδομένα του Ευκλείδη, ενός εκ των δύο σωζόμενων έργων του Μαρίνου του Νεαπολίτη. Τόσο στην κριτική έκδοση του Menge όσο και σε όλες τις άλλες μεταφράσεις του Υπομνήματος που ακολούθησαν, εμφανίζεται ένα μεταφραστικό ατόπημα σχετικά με την απόδοση της φράσης «τὸ λογικὸν πρὸς τὸ πεζόν». Ο στόχος του παρόντος σημειώματος είναι να αποκαταστήσει το νόημα του αρχαίου ελληνικού κειμένου και να αναδείξει τις δυνατές προεκτάσεις της προτεινόμενης μετάφρασης.
Το ζήτημα της φροντίδας στα υβριδικά σώματα
Authors: Πατεράκη Μαριλένα
Published: September 2024

Στόχος της παρούσας μελέτης είναι η εξέταση του ζητήματος της φροντίδας των cyborg εμφυτευμένων σωμάτων. Θα αναδείξω το γεγονός ότι, αντίθετα με ντετερμινιστικές θεωρήσεις, η υποδόρια σύζευξη βιολογικού/μηχανικού, και η δημιουργία μιας νέας οντότητας που κατευθύνεται υβριδικά στον κόσμο, δεν αποτελεί μια απλή και γραμμική διαδικασία που εξαλείφει τις αναπηρίες και τις χρόνιες ασθένειες, καθιστώντας περιττές τις πρακτικές φροντίδας και ευρύτερα την ανθρώπινη εργασία. Αντιθέτως, η σύζευξη αυτή ενέχει πολυπλοκότητες οι οποίες εντοπίζονται μέσα σε ένα ευρύ φάσμα πρακτικών και υλικοτήτων, που εκδιπλώνονται εντός πολλαπλών χρονικοτήτων. Με αυτόν τον τρόπο, η παρούσα μελέτη αναδεικνύει ότι η φροντίδα των cyborg σωμάτων όχι μόνο δεν εξαλείφεται, αλλά περιπλέκεται, στο βαθμό που δημιουργούνται νέα ευάλωτα μέσω της σύζευξης, ενώ επιπλέον τα όρια μεταξύ φροντίδας και συντήρησης θολώνουν. Τα αποτελέσματα που παρουσιάζονται στηρίζονται σε μια ποιοτική έρευνα που διεξήγαγα βάσει της μεθοδολογίας της grounded theory με πλαισίωση από το πεδίο ‘Επιστήμη, Τεχνολογία, Κοινωνία’ (STS) και με αντικείμενο την εν τω βάθει εγκεφαλική διέγερση (deep brain stimulation, DBS) και την εφαρμογή της στην Ελλάδα σε άτομα με νόσο Πάρκινσον (ΝΠ).
Οι σειρές του McTaggart και η αρχαία φιλοσοφία για τον χρόνο
Authors: Γκολίτσης Παντελής
Published: September 2024

Η θέση του McTaggart ότι ο χρόνος δεν υπάρχει εξακολουθεί να απασχολεί τους φιλοσόφους της μεταφυσικής του χρόνου. Ενώ οι φιλόσοφοι υπερασπίζονται την ύπαρξη είτε της πρώτης σειράς (A series) είτε της δεύτερης σειράς (B series), ο ίδιος ο McTaggart θεωρούσε ως  πραγματική την τρίτη σειρά (C series), η οποία, σε αντίθεση με τις δύο προηγούμενες χρονικές σειρές, είναι άχρονη. Υποστηρίζω ότι οι αρχαίες αντιλήψεις για το χρόνο, ειδικά του Αριστοτέλη και του Δαμασκίου, υπερκεράζουν τον ισχυρισμό του McTaggart ότι ο χρόνος δεν υπάρχει, καθώς εξηγούν αναδρομικά πώς η δεύτερη σειρά μπορεί να δημιουργείται από την τρίτη σειρά χωρίς την εμπλοκή της πρώτης σειράς, για την οποία έδειχνε ο McTaggart ότι έχει αντιφατικό χαρακτήρα. Η σύγκριση αυτή μάς δίνει τη δυνατότητα να δούμε όχι μόνο ότι ο Δαμάσκιος ήταν ο πρώτος παροντιστής στην ιστορία της μεταφυσικής του χρόνου, αλλά και ότι η ανάλυση του McTaggart στηρίζεται στη σιωπηλή παραδοχή ότι ο χρόνος εξελίσσεται γραμμικά.
Programas de intervención en competencias emocionales y sociales para alumnado con TDAH.
Authors: Cabello-Sanz Sandra , Otero-Mayer Andrea , González-Benito Ana
Published: September 2024

El Trastorno por Déficit de Atención con Hiperactividad (TDAH) presenta una elevada incidencia entre los escolares, generando dificultades no solo de tipo cognitivo sino también en los ámbitos interpersonal e intrapersonal. El objetivo de este trabajo de revisión sistemática es analizar las características generales de los programas de educación socioemocional diseñados e implementados para alumnado con TDAH en el contexto escolar a nivel nacional e internacional. Para ello, siguiendo el método PRISMA, se realiza una búsqueda en las principales bases de datos como ERIC, Scopus, Web of Science y Dialnet identificándose en primer lugar 306 registros, de los cuales solo 28 cumplieron los criterios de inclusión establecidos. Los resultados reflejan que, con carácter general, los programas se desarrollan desde una perspectiva colaborativa haciendo partícipes al profesorado, a la familia y al alumnado, siendo en la etapa de Educación Primaria donde se concentran el mayor número de actuaciones psicopedagógicas. Resultaría favorable incrementar las investigaciones en los primeros ciclos de la etapa para potenciar la detección del trastorno e intervención temprana. Asimismo, los profesionales de la educación y orientación deben concienciarse sobre las repercusiones positivas del desarrollo de programas de educación socioemocional para el alumnado en general, viéndose beneficiados en su conjunto toda la comunidad educativa
1Avances en Psicología Latinoamericana / Bogotá (Colombia) / Vol. 42(1) / pp. 1-17 / 2024 / ISSNe2145-4515 “Just do it”: Hedonic Shopping Motivations Predicting Consumer Behavior Beyond Personality
Authors: Aquino Sibele Dias de , Natividade Jean C.
Published: September 2024

The present study aimed at testing hedonic shopping motivations’ explanatory power for the impulsive buying tendency and specific buying behaviors. It also presents psychometric properties of the adapted Brazilian version of the Hedonic Shopping Motivations (HSM) scale. This scale assesses six factors of hedonic motives for shopping: Adventure shopping, gratification shopping, role shopping, value shopping, social shopping, and idea shopping. After the translation process, 429 adults (Mage = 34.5; 73,7 % women) completed the instrument. Confirmatory factor analyses indicated that the six-factor model was the best fit for the data, the same as the instrument’s original version. The factors also showed satisfactory reliability indices. Although we found significant correlations between hsm and the Big Five Factors, these correlations were only weak. Conversely, we found moderate positive correlations between the adventure, gratification, and idea factors of the hsm scale and impulsive buying. The instrument showed satisfactory evidence of validity, indicating the scale’s reliability for use in Brazil. The results also indicated that the hsm scale predicted specific purchase behaviors and impulsive buying beyond the Big Five. This study expands our understanding of individual differences in purchasing behaviors, especially by showing that gratification is the best predictor of impulsive buying.
Multiobjective Linear Ensembles for Robust and Sparse Training of Few-Bit Neural Networks
Authors: Bernardelli Ambrogio Maria , Gualandi Stefano , Milanesi Simone , Lau Hoong Chuin , Yorke-Smith Neil
Published: September 2024

Training neural networks (NNs) using combinatorial optimization solvers has gained attention in recent years. In low-data settings, the use of state-of-the-art mixed integer linear programming solvers, for instance, has the potential to exactly train an NN while avoiding computing-intensive training and hyperparameter tuning and simultaneously training and sparsifying the network. We study the case of few-bit discrete-valued neural networks, both binarized neural networks (BNNs) whose values are restricted to ±1 and integer-valued neural networks (INNs) whose values lie in the range [Formula: see text]. Few-bit NNs receive increasing recognition because of their lightweight architecture and ability to run on low-power devices: for example, being implemented using Boolean operations. This paper proposes new methods to improve the training of BNNs and INNs. Our contribution is a multiobjective ensemble approach based on training a single NN for each possible pair of classes and applying a majority voting scheme to predict the final output. Our approach results in the training of robust sparsified networks whose output is not affected by small perturbations on the input and whose number of active weights is as small as possible. We empirically compare this BeMi approach with the current state of the art in solver-based NN training and with traditional gradient-based training, focusing on BNN learning in few-shot contexts. We compare the benefits and drawbacks of INNs versus BNNs, bringing new light to the distribution of weights over the [Formula: see text] interval. Finally, we compare multiobjective versus single-objective training of INNs, showing that robustness and network simplicity can be acquired simultaneously, thus obtaining better test performances. Although the previous state-of-the-art approaches achieve an average accuracy of [Formula: see text] on the Modified National Institute of Standards and Technology data set, the BeMi ensemble approach achieves an average accuracy of 68.4% when trained with 10 images per class and 81.8% when trained with 40 images per class while having up to 75.3% NN links removed.

History: Accepted by Andrea Lodi, Area Editor for Design & Analysis of Algorithms—Discrete.

Funding: This research was partially supported by the European Union Horizon 2020 Research and Innovation Programme [Grant 952215]. The work of A. M. Bernardelli is supported by a PhD scholarship funded under the “Programma Operativo Nazionale Ricerca e Innovazione” 2014–2020.

Supplemental Material: The software that supports the findings of this study is available within the paper as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2023.0281 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Can You Go Home Again? Performance Assistance Between Boomerangs and Incumbent Employees
Authors: Grohsjean Thorsten , Dokko Gina , Yang Philip
Published: September 2024

Boomerangs, that is, rehires, should have advantages over other new hires when integrating into an organization due to their familiarity with the work context and their pre-existing relationships. However, research suggests that the effects of hiring boomerangs may not be straightforwardly positive. To better understand these effects, we investigate how boomerangs’ social integration into a work team differs from that of other new hires due to their pre-existing relationships and how those relationships shape their and incumbents’ competence and motivation to provide assistance for collective performance. We theorize and find that boomerangs, compared with new hires, exhibit more performance assistance toward incumbent former and incumbent new colleagues. In contrast, incumbent former colleagues do not direct their performance assistance toward boomerangs, contrary to our prediction, nor do incumbent new colleagues. This study contributes to the nascent literature on boomerangs and the literature on job mobility by finding evidence that prior relationships condition the behavior of both boomerangs and incumbents.

Supplemental Material: The online appendix is available at https://doi.org/10.1287/orsc.2022.16685 .
Clinical Characteristics and Risk Factors of Sepsis in Patients with Liver Abscess
Authors: Wang Kai , Guo Wei , Zhu Jihong , Guo Yang , Gao Weibo
Published: September 2024

Aims/Background Liver abscess (LA) is a serious medical condition that predisposes patients to sepsis. However, predicting sepsis in LA patients has rarely been explored. This study employed univariate and multivariate logistic regression analyses to identify independent risk factors for sepsis, which would provide guidance for clinical diagnosis and treatment.

Methods A total of 122 patients with LA treated in Peking University People’s Hospital from 1 January 2016 to 31 October 2022 were recruited. Among the cases, 35 patients had sepsis (sepsis group) while the remaining 87 did not have sepsis (non-sepsis group). Clinical data were collected for all enrolled cases. Univariate analysis was performed to identify potential predictors, which were tested in multivariable logistic analysis to pinpoint the independent risk factors for sepsis in LA patients; these findings were utilized to develop a prediction model. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic efficacy of the prediction model. Informed consent to participate was obtained from the patients or their relatives.

Results The incidence of shivering in the sepsis group was significantly higher than that in the non-sepsis group (p < 0.05). Through the univariate analysis, it was found that the reduction in platelet count and prothrombin time activity and the elevation of glycosylated hemoglobin (HbAlc) and procalcitonin (PCT) were more significant in the sepsis group than in the non-sepsis group (p < 0.05). Multivariate logistic regression analysis revealed that PCT and HbAlc were independent risk predictors of sepsis in LA patients within the derivation cohort (p < 0.05).

Conclusion Elevated levels of HbAlc and PCT were independent risk factors for sepsis associated with LA. Patients with LA exhibiting elevated PCT levels demonstrated a 21% increased susceptibility to sepsis, and those with elevated HbAlc levels showed a 38% heightened risk for sepsis.
THREE ENEMIES OF THE WORKER IN THE GRAPES OF WRATH: THE BANK, MECHANISATION, UNEMPLOYMENT
Authors: Karakoç Murat
Published: September 2024

Abstract
With its various effects, the Great Depression was one of the biggest events that shaped the modern world. As John Steinbeck handles in The Grapes of Wrath, unemployment, hunger and homelessness spread, and workers had to leave their hometowns and migrate to big cities in order to eat a piece of bread. One of the issues handled by Steinbeck is the influence of the banks as the representative power of the capital. Due to the widespread unemployment, people are unable to find permanent jobs, and as a result, they fail to earn enough money to meet their needs. This fact force them to depend on banks for finance. Yet, as they cannot find money to pay their debts, they have to sell everything they own. Banks make people landless, unemployed, homeless, broke and even hungry. It is easy to understand the harsh realities of that period thanks to the journey of the Joad family in the novel. In this article, first information will be given about what caused the birth of the American capitalist system and how this system became successful in its development. And then how the system is reflected in The Grapes of Wrath will be discussed. How capitalism successfully operated through banks, machinery and the resultant widespread unemployment will also be analyzed. Finally, how this poison spread into poor people’s lives through the loan system of the banks made people increasingly selfish and how this selfishness turned them into deadly monsters will be explained, by taking into account the events that Joad family encountered on their journey to find a better life.
Keywords: The Great Depression, Capitalism, Banks, Grapes of Wrath, The Joad family