bluuebunny/crossref_metadata_2025 huggingface dataset:
A therapeutic approach to mitigate SARS CoV2 infection using natural furin inhibitor(s)
Authors: Paul Dhiman , Bhattacharjee Minakshi , Mahato Dhani Ram , Sarma Manash
Published: March 2022

Purpose: The COVID 2019 has had been going pandemic as per WHO
situation reports. The major differentiating point in this virus is the
presence of a unique furin cleavage site. Our insilico study points out
to the effectiveness of a potent plant origin furin inhibitor. We
exploited the aspect of the cleavage machinery of furin subunits which
is critical and indispensible to the entry of SARS-CoV-2 in human cells
and subsequent massive contagion. Methods: In-silico analysis
was done to observe the interactions of proposed analogs of protease
inhibitor of plant origin against furin protein as well as the furin
spike glycoprotein binding machinery. This was done by docking protocols
using Hex 6.0 software followed by molecular Dynamic simulation (MDS)
analysis in 100ns scale using Amber94. Further, the images were analysed
with PyMol software. Results: The analogs I, II and III
included in our study showed strong interactivity against furin
individually, as well as the furin-Spike Glycoprotein 1 binding
machinery. The findings were confirmed using molecular dynamic
simulation analysis which indicated good structural stability and
ability to neutralise furin and furin-spike glycoprotein 1. Analog II
was found to be the best interactive molecule against furin, showing the
least deviation (1.484 ± 0.0064). Also, it was the most effective
against furin + Spike glycoprotein I (SGP I) machinery [1.575±
0.01]. Major conclusions: We report the first of its kind of
natural furin inhibitor(s) which would disrupt the furin machinery of
SARS CoV2 and help in controlling the CoViD 19 contagion.
Assessment of fatigue in postpartum women using patient-reported outcome measures: a systematic review utilising Consensus Based Standards for the Selection of Health Measurement Instruments (COSMIN) guidelines
Authors: Ciechanowicz Sarah , Pandal Perman , Carvalho Brendan , Blake Lindsay , Damme Stefaan Van , Taylor Jan , Sultan Pervez
Published: March 2022

Background Fatigue is a burden for a substantial proportion of women in
the postpartum period. A wide array of patient-reported outcome measures
(PROMs) are used for assessment, which makes comparison of data
difficult. Objective To identify the best PROM for postpartum fatigue
using Consensus Based Standards for the Selection of Health Measurement
Instruments (COSMIN) guidelines. Search strategy We searched Web of
Science, Embase, PubMed and CINAHL, with no date limiters, in July 2020
for validated PROMs used to assess fatigue in the postpartum period.
Selection criteria Studies evaluating at least one author-defined domain
of postpartum fatigue and one psychometric measurement property of a
PROM. Data collection and analysis An overall rating was assigned based
upon COSMIN criteria and the quality of evidence was assessed using
Grading of Recommendations Assessment, Development and Evaluation
(GRADE). Main results We identified 49 validation studies using 18 PROMs
in 21 209 women that evaluated postpartum fatigue. All three fatigue
domains (Physical, Mental, Interference) were assessed by four PROMs:
Fatigue Assessment Scale (FAS), Brief Fatigue Inventory (BFI), Checklist
Individual Strength (CIS) and Fatigue Severity Scale (FSS). The FAS,
which is freely available online, was the only PROM to demonstrate
adequate content validity and at least a low level evidence of
sufficient internal consistency, resulting in a Class A recommendation.
Conclusion The FAS is the best available PROM to assess postpartum
fatigue. However, it fails to assess important areas of postpartum
recovery. Future studies should aim to develop a more specific PROM for
postpartum fatigue.
Quality appraisal of guidelines on umbilical cord prolapse with AGREE II: a systematic review
Authors: Rajamani Aaron Prasad Pual , Zaki Muhammad Zarul Azham Mohd , Ravindran Raajeswari , Nalliah Sivalingam
Published: March 2022

Background: Umbilical cord prolapse is an obstetric emergency that
warrants urgent intervention. Although the incidence is low, it carries
a high rate of fetal morbidity and mortality. Quality appraisal of well-
developed practice guidelines provides clinicians with a framework for
good clinical practice. Objective: To assess the quality of clinical
practice guidelines on umbilical cord prolapse using AGREE II
instrument-2010. Search strategy: A systematic review employing the
principles of PRISMA 2020 was done to identify suitable practice
guidelines available in digital databases from inception till 2021.
Selection criteria: Practice guidelines on management of umbilical cord
prolapse in English which have rigorous methodology of development and
is between 2010-2021 were selected for the appraisal. Data collection
and analysis: Selected guidelines were appraised utilizing the AGREE-II
- 2010 instrument Results: Three practice guidelines were fulfilled the
selection criteria. Two of the three guidelines were assigned sufficient
scores based on the domains for quality appraisal, though they require
further modifications. Conclusions: Practice guidelines on management of
umbilical cord prolapse developed by the RCOG and RCPI achieved
sufficient scores to be recommended for use in clinical practice.
Professionals should provide patient care based on practice points
tailored to patients’ characteristics and resource availability.
Keywords: umbilical cord prolapse, guidelines, clinical practice
guidelines, quality appraisal Tweetable abstract: AGREE II was used to
assess the quality of CPGs on umbilical CP, of which RCOG and RCPI
guidelines were recommended.
Physical therapy for end-stage haemophilia arthropathy: A case report
Authors: Gao Zhenzhen , Yang Hang , Liu Wenbin , Wang Lingcong , Mao Yajun
Published: March 2022

This report introduces a patient with end-stage haemophilia arthropathy.
He had a unique background and presentation, with challenges such as
joint stiffness, muscular atrophy, severe pain, decrease in
cardiopulmonary and vestibular function. Finally, he achieved the basic
self-care of daily life through comprehensive physical therapy.
THORACOSCOPIC ABLATION IN SITUS INVERSUS DEXTROCARDIA WITH INTERRUPTED INFERIOR VENA CAVA CONTINUATION IN AZYGOS VEIN
Authors: Rosati Fabrizio , F Rattenni , L Di Bacco , D'Alonzo Michele , Curnis Antonio , Muneretto Claudio , S. Benussi
Published: March 2022

INTRODUCTION Situs inversus totalis, dextrocardia with interrupted
inferior vena cava and azygos vein continuation concomitant with
symptomatic atrial fibrillation requiring ablation. This case was deemed
not suitable for percutaneous ablation due to anatomic variations and
the lack of case reports in literature. METHODS AND RESULTS We performed
bilateral thoracoscopic epicardial ablation and epicardial left atrial
appendage exclusion. The direct vision allowed for a complete box lesion
set with bipolar radiofrequency device. Patient remained in sinus rhythm
at 12-months follow-up. CONCLUSION Surgical thoracoscopic epicardial
ablation is safe and effective also in congenital defects.
Multidisciplinary expertise can offer minimally invasive ablation
treatments.
Chromosome-level genome assembly of Tibetan macaque (Macaca thibetana) and species-specific structural variations
Authors: Zhang Rusong , Zhou Chuang , Jin Xianlin , Liu Kanghua , Fan Zhenxin , Xing Jinchuan , Li Jing
Published: March 2022

The Tibetan macaque (Macaca thibetana) is an endemic macaque species in
China belonging to the sinica group in genus Macaca. Here, we report the
first chromosome-level genome assembly for the Tibetan macaque using
PacBio long-read sequencing and Hi-C technology. The assembled Tibetan
macaque genome was 2.82 Gbp in size with contig N50 of 48.75 Mbp and
scaffold N50 of 150.62 Mbp, which was anchored to 22 chromosomes.
Compared to the chromosome-level genome of rhesus macaque and cynomolgus
macaque, the genome size of the Tibetan macaque is the smallest and the
assembly quality is the best. A total of 22,485 protein-coding genes and
1.33 Gbp repeat sequences were annotated in the Tibetan macaque genome.
Phylogenetic analysis indicated the Tibetan macaque was closely related
to the stump-tailed macaque and diverged from a common ancestor 5.06
million years ago. A total of 977 positively selected genes were
identified, which were enriched in pathways related to the thyroid,
diabetes mellitus, fatty acid biosynthesis and metabolism. Among them,
11 genes associated with tail development and 9 genes associated with
body size were found to be under positive selection, which might
contribute to short tail and large body size of the Tibetan macaque. The
structural variation (SV) analysis between the Tibetan macaque and other
macaques identified 6,778 Tibetan macaque-specific SVs. Among them,
three deletions and four insertions in six genes might be associated
with tail development and body size. The high-quality genome of the
Tibetan macaque will benefit further biological and evolutionary studies
on primates.
CRISPR Cas13a: A Potential Therapeutic Cure for HIV Infection in Humans
Authors: Sharma Avinash , Siddiqui Adeeb Ahmad , K Akash , Kumar Deepak , N Deepak Kapoor , Nagraik Rupak
Published: March 2022

Human Immunodeficiency Virus (HIV), is a lethal virus that infects the
human immune system. Once the person gets infected with HIV, the
infection will gradually lead to AIDS which attacks the immune system
and ultimately causes death if proper precautionary measures are not
taken against it. Currently, anti-viral therapies and drugs combined
with this are utilized by patients diagnosed with HIV. But with rapid
mutation capabilities, the virus showcased resistance to the drugs,
therefore, pushing the scientific community to explore a more stable and
rapid treatment option for HIV. Recently, the utilization of CRISPR Cas
technologies for genetic modification, disease diagnosis, disease
treatment, and biosensing technologies has greatly increased due to
their numerous advantages. This review focuses on the working mechanism
of CRISPR Cas13a that is divided into its stages followed by the
conventional methods used for HIV treatment, we also highlighted the
potential applications that use Cas13 protein for its working principle
and finally the usage of Cas13a towards HIV diagnosis, treatment, and
prospects of this technology.
Combining in vitro and in vivo screening to identify efficient Pseudomonas biocontrol strains against the phytopathogenic bacterium Ralstonia solanacearum
Authors: Clough Sophie , Jousset Alexandre , Elphinstone John , Friman Ville‐Petri
Published: March 2022

While plant pathogens are traditionally controlled using synthetic
agrochemicals the availability of commercial bactericides is still
limited. One potential control strategy could be the use of
plant-growth-promoting bacteria (PGPBs) to suppress pathogens via
resource competition or the production of antimicrobial compounds. This
study aimed to conduct in vitro and in vivo screening of eight
Pseudomonas strains against Ralstonia solanacearum (the causative agent
of bacterial wilt) and to investigate underlying mechanisms of potential
pathogen suppression. We found that inhibitory effects were Pseudomonas
strain-specific, with strain CHA0 showing the highest pathogen
suppression. Genomic screening identified 2, 4-diacetylphloroglucinol
(DAPG), pyoluteorin, and orfamides A and B secondary metabolite clusters
in the genomes of the most inhibitory strains, which were investigated
further. While all these compounds suppressed R. solanacearum growth,
only Orfamide A was produced in the growth media based on mass
spectrometry. Moreover, orfamide variants extracted from Pseudomonas
cultures showed high pathogen suppression. Using the Micro Tom tomato
cultivar, it was found that CHA0 could reduce bacterial wilt disease
incidence with one of the two tested pathogen strains. Together, these
findings suggest that a better understanding of Pseudomonas-Ralstonia
interactions in the rhizosphere is required to successfully translate in
vitro findings into agricultural applications.
Intrapelvic Migration of the Lag Screw in intramedullary nailing after intertrochanteric fracture fixation : Report of a case
Authors: Fredj Aymen Ben , Rbai Hedi , Farhat Fourat , Berriri Marouen
Published: March 2022

The expected number of hip fractures worldwide will rise from 1.7
million in 1990, to 6.3 million in 2050. In parallel, surgical
complications are expected to increase. We describe a rare complication
of intrapelvic migration of the lag screw from trochanteric nail in a
90-year-old patient.
Hemophagocytic Lympho-Histiocytosis Secondary to Rickettsial Infection: A Case Report
Authors: Sharma Shriya , Adhikari Aakriti , Ghimire Nirmal , Mainali Gaurab , Yadav Sumit , Pudasaini Prasamsa , Neupane Shashank
Published: March 2022

Hemophagocytic Lympho-histiocytosis (HLH) is a rare life-threatening
condition characterized by widespread activation of the immune system
leading to tissue damage all over the body.
Childhood Guillain-Barre´ syndrome in the SARS-CoV-2 Era: Is there any causative relation?
Authors: Pourbakhtyaran Elham , Heidari Morteza , Akbar Masood Ghahvechi , Mohammadi Mahmoud , Badv Reza Shervin , Zamani Gholam Reza , Tavasoli Ali Reza , Rezaei Zahra , Mamishi Setareh , Memar Elmira Haji Esmaeil , Hosseiny Seyyed Mohammad Mahdi , Ghabeli Homa , Haghighi Roya , Ashrafi Mahmoud Reza
Published: March 2022

We reported an association between SARS-CoV-2 infection and
Guillain-Barre´ syndrome (GBS). From 37 patients with GBS, Previous
SARS-CoV-2 infection clues, including fever, cough, and diarrhea were
recorded in 18 patients. Among them, SARS-CoV-2 IgG was detected in 7
patients, considered confirmed cases. SARS-CoV-2 PCR was positive in
just 1 patient.
A novel hybrid recommender system approach for student academic advising named COHRS, supported by case-based reasoning and ontology
Authors: Obeid Charbel , Lahoud Christine , El Khoury , Champin Pierre-Antoine
Published: March 2022

The recent development of theWorldWideWeb, information, and communications technology have transformed the world and moved us into the data era resulting in an overload of data analysis. Students at high school use, most of the time, the internet as a tool to search for universities/colleges, university?s majors, and career paths that match their interests. However, selecting higher education choices such as a university major is a massive decision for students leading them, to surf the internet for long periods in search of needed information. Therefore, the purpose of this study is to assist high school students through a hybrid recommender system (RS) that provides personalized recommendations related to their interests. To reach this purpose we proposed a novel hybrid RS approach named (COHRS) that incorporates the Knowledge base (KB) and Collaborative Filtering (CF) recommender techniques. This hybrid RS approach is supported by the Casebased Reasoning (CBR) system and Ontology. Hundreds of queries were processed by our hybrid RS approach. The experiments show the high accuracy of COHRS based on two criteria namely the ?accuracy of retrieving the most similar cases? and the ?accuracy of generating personalized recommendations?. The evaluation results show the percentage of accuracy of COHRS based on many experiments as follows: 98 percent accuracy for ?retrieving the most similar cases? and 95 percent accuracy for ?generating personalized recommendations?.
An intradialytic aerobic exercise program ameliorates frailty and improves dialysis adequacy and quality of life among hemodialysis patients: a randomized controlled trial
Authors: Kim Sunki , Park Hye-Ja , Yang Dong-Ho
Published: March 2022

Background: Hemodialysis patients with chronic kidney disease exhibit impaired exercise tolerance and functional decline. Despite the life-saving benefits of adequate dialysis, those declines translate into frailty and deteriorating quality of life (QoL). This study evaluated the effects of an intradialytic aerobic exercise program on frailty, dialysis adequacy, and QoL among hemodialysis patients. Methods: Patients at an university hospital-affiliated hemodialysis center were randomly assigned to an exercise group (n = 18) or a control group (n = 21). The 12-week aerobic exercise program comprised 40 to 70 minutes of ergometer cycling 3 times/wk and a single education session. The control group completed only the education session. Outcomes were assessed at the time of enrollment, week 4, week 8, and week 12 using Fried’s frailty phenotype measures (gait speed, grip strength, vitality, body mass index, and physical activity), the short physical performance battery (SPPB), Kt/V urea, and the Short Form-36 questionnaire. Results: There were significant interactions between groups and follow-up times in the frailty score (p < 0.001), gait speed (p < 0.001), SPPB (p < 0.001), and mental QoL (p = 0.03). The intention-to-treat and per-protocol analyses revealed that the exercise group exhibited significant improvements in frailty score (p < 0.001), gait speed (p < 0.001), grip strength (p < 0.001), exhaustion (p = 0.02), SPPB (p = 0.01), dialysis adequacy (p = 0.01), and physical QoL (p = 0.003). Conclusion: An intradialytic aerobic exercise program could be a safe, feasible, and appropriate additional strategy to routine care among hemodialysis patients for improvements in frailty, dialysis adequacy, and QoL.
Longitudinal Study of Metacognitive Skills and External Representation of Students in the Context of Problem-Solving
Authors: Ijirana Ijirana , Mansyur Jusman , Rizal Muh. , Aminah Sitti
Published: March 2022

This study aims to longitudinally describe the metacognitive skills and external representation in the context of problem-solving at Chemistry Education, Tadulako University. The qualitative study respondents were selected from a number of first year students for two consecutive semesters. Two respondents were selected based on results of selection using a metacognitive skills assessment questionnaire (MCAI) and we categorized as high and medium.  Three problems were resolved by respondents at intervals of one to two weeks in each semester through a one-on-one thinking aloud and it was followed by a semi-structured interview. Data collection was recorded using a video camera. Metacognitive skills and external representation data from the odd and even semesters were deeply analyzed. This analysis technique was carried out by examining the results of problem solving and semi-structured interviews in detail and matching them with the indicators of metacogni-tive skills and external representation used by both respondents. The data analysis results showed that the thinking ability of respondents with high metacognitive skills in problem solving, experienced developments over time along with the development of their cognitive regulation and external representation. On the other hand, respondents with intermediate metacognitive skills during problem solving, were relatively the same for two consecutive semesters. Therefore, teachers need to consider the use of learning strategies by taking into account the number of students who have dominant characteristics in classroom learning, in terms of metacog-nitive skills and external representation.
Interactive Android Module Development Containing Three Chemical Representation Levels on Material of Salt Hydrolysis
Authors: Zamhari Muhammad , Ridzaniyanto Pandu , Kangkamano Tawatchai
Published: March 2022

Three chemical representation is an important aspect of chemistry learning. However, the database study shows that interactive chemistry learning media containing three levels of representation is not available. This research aims to develop and assess the feasibility of an interactive Android-based learning module for senior high school students containing three chemical representation levels on the material of salt hydrolys-is. The study was conducted using research and development (RD) method.  Stages of research were con-ducted as follows, analysis, development process, product validation and assessment. The Android module was subsequently validated by media and concept experts and then limitedly assessed by five chemistry teachers and ten senior high school students. The instrument used was validated by an instrument expert. The validation results by media and concept experts indicated that the media was valid in terms of media performance and salt hydrolysis material. Based on teachers' and students' assessments, the media received a score of 87.5% and 83.0%, with very good category. It can be concluded that the interactive Android-based learning module containing three chemical representations on the material of salt hydrolysis was successful-ly developed and can be tested extensively in senior high school. The developed media closed a significant gap in the need of interactive chemistry learning media containing three levels of chemical representation, especially in the material of salt hydrolisis
Learning Social Arithmetic of Low-Ability Student through the Context of Snacks and Money
Authors: Hardini Risty Mustika , Prahmana Rully Charitas Indra , Akib Irwan , Shahrill Masitah
Published: March 2022

Low-ability students are evidenced to have difficulties in understanding the concept of abstraction in mathematics, such as social arithmetic problems. It is because low-ability students have an IQ below the average of 70 to 90. Most teachers find it challenging to discover what kind of learning approaches that may be suitable for improving their mathematical understanding. An alternative approach that can be used to improve the understanding of low-ability students is the Indonesian Realistic Mathematics Education (IRME) approach by using real contexts as a starting point for learning to make it easier for students to study the abstract material. This study aims to determine the learning process and the role of IRME in improving low-ability student’s mathematical cognitive abilities regarding the concept of social arithmetic. This study used the Single Subject Research (SSR) method with a single subject, and a seventh-grade student at one of the Junior High Schools in Depok, Yogyakarta. The research data collected in this study are audio and video recordings, photos, and student worksheets. The data collected was then analyzed using in and between analysis with A-B research design. The results showed that the IRME approach with snack and money con-texts could improve a low-ability student’s mathematical understanding of the social arithmetic concept. This context could be a starting point for teachers in teaching social arithmetic problems and be a reference for finding other contexts that can make mathematics learning more easy and joyful for low-ability students.
Developing Management and Leadership Training Innovation Program for Higher Education at Muhammadiyah Universities
Authors: Samsudin Muh , Shodiq Sadam Fajar , Manan Nanan Abdul , Jannah Widia Nur , Wachidi Wachidi , Rusdarti Rusdarti , Dasuki Mustofa
Published: March 2022

The management and leadership training innovation model used by Muhammadiyah universities according to the principles of good instructional development is not yet available. The aims of this research are (1) to describe the appropriate management and leadership training for university leaders at Muhammadiyah universities today; (2) to identify current approaches to management and leadership training; (3) to develop suitable management and leadership training packages for leaders; and (4) to formulate the effectiveness of the innovation management and leadership training package. Research and Development Borg and Gall were used and combined with Dick Carey's steps Instructional Design Modern. The study resulted in the package management and leadership training for Muhammadiyah, including training design, A Handbook for Facilitators, Handbook for Participants, and Module 3 Training Materials. Product Training Package has been validated by and trials on aspects of effectiveness and feasibility. The study also produced some impli-cations and recommendations relating to the training in the PTM (Muhammadiyah Higher Education).
Situación actual del médico ecuatoriano: una incómoda realidad
Authors: Ricardo López , Karolain Tapia
Published: March 2022

En la actualidad los profesionales de la salud en nuestro país se han enfrentado a un problema sanitario de proporciones colosales en un sistema de salud saturado, evidenciando una incipiente necesidad de actualización, mejora y formación de talento humano especializado. El presente documento expone una serie de datos que presentan la realidad del profesional de la salud en cuanto a la oferta y demanda de plazas de especialidad a nivel nacional.
Incidentes preanalíticos en muestras biológicas en el Laboratorio Clínico del Hospital de Especialidades Eugenio Espejo (HEEE) Quito – Ecuador 2016.
Authors: Miño Rodrigo , Reinoso Karina , Salazar Ximena , Galarza Sara
Published: March 2022

Introducción: Asegurar la calidad en el proceso preanalítico es primordial ya que la mayoría de los errores se producen en esta fase. Objetivo: Determinar la frecuencia y el tipo de incidentes preanalíticos de las muestras biológicas que llegaron al laboratorio clínico del HEEE de agosto a diciembre de 2016. Método: Se realizó un estudio descriptivo transversal que consideró los incidentes preanalíticos de las muestras en el laboratorio clínico del HEEE de agosto a diciembre de 2016. Se calcularon las prevalencias mensuales de los tipos de incidentes, el desempeño sigma y se utilizó el diagrama de Pareto para identificar las causas más frecuente. Resultados: De un total de 149534 muestras recibidas, 7762 tuvieron un incidente preanalítico esto es el 5,2% del total, desempeño sigma de 3,2. Se rechazaron un total de 844 muestras, el 0,6% del total. La mayoría de incidentes preanalíticos ocurrieron en el registro de datos de los pacientes en la solicitud de exámenes. El incidente más común relacionado con la toma de muestra fue “cantidad insuficiente de sangre con respecto al volumen de anticoagulante”. Conclusión: El desempeño del proceso preanalítico del Laboratorio Clínico del HEEE se puede mejorar y, en comparación con otros centros de salud muestra un desempeño similar, no obstante, el riesgo de liberar información equivocada es residual. La institución debe establecer acciones para disminuir la cantidad de errores que se presentan en el área preanalítica para mitigar el riesgo y optimizar los recursos.
Conformación e individualización de los arcos ortodónticos en auxilio a la biomecánica y estabilidad pos-tratamiento
Authors: Carrasco Peña Mylene del Carmen , Gonzaga do Amaral Sobrinho L.
Published: March 2022

La forma y tamaño de la arcada dental del ser humano ha sido estudiada por más de un siglo. En este periodo de tiempo existen diversas investigaciones con la intención de relacionar las formas y tamaño de arco dental entre diferentes razas, el sexo o también el tipo de mal oclusión dental o esqueletal. Debido a que la forma de arco dental puede presentar variaciones, se han propuesto distintos análisis de formas matemáticas, geométricas y métodos computarizados, con la intención de facilitar la representación de la forma de arco dental. Para el ortodoncista es importante clasificar la forma de arco dental del paciente, especialmente si se utilizan alambres con formas de arco con memoria, ya que estos contienen información que trasmiten a través de la aparatología fija a los dientes y tejidos adyacentes. Elegir una forma de arco inadecuada puede crear problemas de recidiva después del tratamiento de ortodoncia.
Indice neutrófilo/linfocito y coinfección bacteriana en pacientes críticos con covid-19
Authors: Vélez-Páez Jorge Luis , Cornejo-Loor Luis , Castro-Bustamante Christian
Published: March 2022

El índice neutófilo/linfocito se obtiene de la división del contaje absoluto de neutrófilos para el contaje absolutos de linfocitos y es un buen marcador inflamatorio utilizado en diversas patologías.

En esta imagen estadística, observamos el comportamiento del INL (Indice neutrófilo/linfocito) en la co-infecciòn bacteriana tardía en pacientes con COVID-19 en estado crítico; en dónde su medición realizada 72 horas antes de la toma de cultivos (sangre, secreción traqueal, orina) y luego de la positividad de los mismos, muestra una diferencia estadísticamente significativa (p: 0,020) del INL, entre sus valores medios del día de la toma de los cultivos (18,83) y del día de la positividad del mismo (28,62). Por ésta razón, esta biomarcador hematológico lo estamos utilizando como una herramienta para el diagnóstico de co-infección bacteriana.

Esperamos poder publicar los resultados de éste trabajo posteriormente, por el momento, les compartimos ésta imagen médica.
Editorial
Authors: Vélez Jorge
Published: March 2022

La publicación científica es el medio por el cual en el mundo se expone el trabajo literario científico de una comunidad médica. En la era actual la investigación aporta con evidencia científica las acciones asistenciales de los profesionales médicos. La lectura crítica es lo recomendado para evaluar esa información. No obstante el criterio anterior real para muchos, es menos compartido por otros afines al trabajo basado en la experiencia. Se debe resaltar la importancia de las dos estrategias en la formación médica y es muy probable que si William Osler padre de la enseñanza de la medicina basada en el enfermo a finales del siglo XIX que por primera vez evocó ya el método científico estuviera presente, compartiría con D.L. Sackett, uno de los pontífices de la medicina basada en laevidencia a inicios del siglo XXI que el médico en su labor debe aplicar la mejor evidencia disponible en la literatura científica pero teniendo en cuenta que tal evidencia jamás reemplazará a la habilidad y la experiencia clínica. En el método científico se aplican ambas corrientes y muchos de sus productos se expresan en el contenido de las revistas .
Suomalaisen mediatutkimuksen historiaa 11: Mediavalistuksen vuosikymmenen loppunäytös
Authors: Malmberg Tarmo
Published: March 2022

Suomalaisen mediatutkimuksen historiaa -sarjassa esitellään tekijänsä uran tai alan kehityksen kannalta merkille pantavia töitä. Tarkoitus on samalla herättää kiinnostusta kotimaisen tutkimuksen historiaan, jonka kokonaisesitys on edelleen laatimatta. 

Pertti Hemánus ja Ilkka Tervonen. 1980. Objektiivinen joukkotiedotus. Helsinki: Otava.
Evaluation of Selected Physical Properties of Blighia sapida K. Koenig Wood
Authors: Olayanu Clement M. , Omole Ayodeji O. , Adeyemo Segun M. , Majekobaje Adelodun R. , Areo Olusola S.
Published: March 2022

Blighia sapida, a Lesser-Used Species is being processed into sawn timber to meet the demand for wood. The knowledge of its wood quality would enhance its effective utilization. However, there is little information known on the physical properties of this species that could enhance its acceptability and optimum utilization. This, therefore, necessitate the need to investigate the physical properties of this wood species.

Three standing trees of B. sapida were purposively felled for this study. Billets of 500 mm were obtained from the wood disc at the base, middle, and top of the tree. Each wood disc was partitioned into three; innerwood, middlewood, and outerwood following specified international standards for the physical properties test (wood colour, proportion of sapwood and heartwood, bark thickness, density, moisture content, and volumetric shrinkage).

B. sapida wood density with a mean value of 709.78±8.88 kg/m3, ranged from (571.59±13.45 to 854.81±7.08 kg/m3. Moisture content percentage of average value 70.62±1.23%, ranged from 53.84±1.40 to 89.00±2.75%. Volumetric shrinkage of average value 15.24±0.25%, range from 13.38±0.66 to 16.89±0.83%. The range of B. sapida wood density value of the study falls within the range that could be categorized as medium density wood of medium construction strength properties. The 1:1.5% tangential–radial shrinkage observed in this study was low, an indicator of a low risk of deformation while seasoning the wood, as the ratios of tangential-radial shrinkage that is high are those over 2.2%.
Staphylococcus aureus-induced pyogranulomatous dermatitis, osteomyelitis, and meningitis with Splendore-Hoeppli reaction in a cat coinfected with the feline leukemia virus and Leishmania sp.
Authors:   Escola de Veterinária, Universidade Federal de Minas Gerais, de Carvalho Thaynara P. , Eckstein Camila ,   Bioclin, Belo Horizonte, MG, de Moura Larissa L. ,   Self-employed veterinarian, Heleno Nathália V. R. ,   Self-employed veterinarian, da Silva Laice A. ,   Escola de Veterinária, Universidade Federal de Minas Gerais, dos Santos Daniel O. ,   Escola de Veterinária, Universidade Federal de Minas Gerais, de Souza Lucas d. R. ,   Escola de Veterinária, Universidade Federal de Minas Gerais, Oliveira Ayisa R. ,   Escola de Veterinária, Universidade Federal de Minas Gerais, Xavier Rafael G. C. ,   Escola de Veterinária, Universidade Federal de Minas Gerais, Thompson Mayerson ,   Bioclin, Belo Horizonte, MG, Silva Rodrigo O. S. ,   Escola de Veterinária, Universidade Federal de Minas Gerais, Santos Renato L. ,   Escola de Veterinária, Universidade Federal de Minas Gerais
Published: March 2022

This report describes a case of a pyogranulomatous dermatitis, osteomyelitis, and meningitis with Splendore-Hoeppli reaction caused by Staphylococcus aureus in a sheltered female adult cat coinfected with the feline leukemia virus (FeLV) and Leishmania sp. The cat had a mild anemia and marked increased total leukocytes, particularly band and segmented neutrophils. The cat had laboratorial diagnosis of FeLV and Leishmania sp. infections. Clinically, the cat had extensive and multifocal areas of ulceration in cranial region. Due to the progression of cutaneous lesions, progressive weight loss, and the risk for other sheltered animals, the cat was euthanized. Microscopically, there was marked pyogranulomatous ulcerative dermatitis, osteomyelitis and meningitis, with multiple large intralesional colonies of Gram-positive cocci associated with Splendore-Hoeppli reaction. Aerobic bacterial isolates were identified as S. aureus by MALDI-ToF MS. Leishmania sp. DNA sequences were detected in liver and spleen, and amastigotes were demonstrated in skin sections by immunohistochemistry. In conclusion, here we describe a case of S. aureus-induced pyogranulomatous meningitis with SH reaction in a cat naturally coinfected with FeLV and Leishmania sp.
Partial pericardial agenesis in a dog
Authors:   Centro de Ciências da Saúde, Universidade de Fortaleza (UNIFOR), Bezerra Lorena S. , Eloi Rômulo S. A. ,   HistoPato Laboratory – Veterinary Anatomopathological Analysis, Santos André L.R.M. ,   HistoPato Laboratory – Veterinary Anatomopathological Analysis, de Oliveira Letícia B. ,   HistoPato Laboratory – Veterinary Anatomopathological Analysis, Araujo José V. ,   Centro de Especialidade Veterinária (CEV), Brasília, Distrito Federal, Blume Guilherme R. ,   HistoPato Laboratory – Veterinary Anatomopathological Analysis
Published: March 2022

Pericardial defects are considered rare in animals and humans. Pericardial agenesis is characterized by partial or total pericardial sac malformation. Here is reported a case of apical partial pericardial agenesis in an adult mixed-breed male dog referred for necropsy. The pericardial sac was absent from the apical region up to the middle area of the ventricles resulting in a bilateral ventricular compression by the remaining pericardium changed the organ conformation. Microscopically, there was evidence of neutrophilic and hemorrhagic myocarditis with cardiomyocyte atrophy and interstitial fibrosis. Agenesis is often a subclinical disorder, and it is an incidental postmortem finding in most cases; however, it can cause complications in cases of cardiac structure herniation.
Spatiotemporal analysis of environmental and physiographic factors related to malaria in Bareilly district, India
Authors: Chaudhary Shikhar , Soman Biju
Published: March 2022

Objectives: The aim of this study was to explore the spatiotemporal clustering of reported malaria cases and to study the effects of various environmental and physiographic factors on malaria incidence in Bareilly district, Uttar Pradesh, India. Methods: Malaria surveillance data were collected from the state health department and cleaned into an analyzable format. These data were analyzed along with meteorological, physiographic, and 2019 population data, which were obtained from the Indian Meteorological Department, National Aeronautics and Space Administration web portal, the Bhuvan platform of the Indian Space Research Organization, and the 2011 Census of India. Results: In total, 46,717 malaria cases were reported in Bareilly district in 2019, of which 25.99% were Plasmodium vivax cases and 74.01% were P. falciparum cases. The reported malaria cases in the district showed clustering, with significant spatial autocorrelation (Moran’s I value=0.63), and space-time clustering (p<0.01). A significant positive correlation was found between monthly malaria incidence and the monthly mean temperature (with a lag of 1−2 months) and rainfall (with a lag of 1 month). A significant negative correlation was detected between the elevation of blocks (i.e., intermediate-level administrative districts) and annual malaria reporting. Conclusion: The presence of space-time clustering of malaria cases and its correlation with meteorological and physiographic factors indicate that routine spatial analysis of the surveillance data could help control and manage malaria outbreaks in the district.
The Emerging Challenges of Adopting BIM in the Construction Industry: Evidence from Sabah, Malaysia
Authors: Syed Jamaludin Shariffah Zatil Hidayah , Ismail Noor Akmal Adillah , Ibrahim Irma Hanie , Japlun Nuraqilla
Published: March 2022

Building Information Modelling (BIM) is the cornerstone of digital transformation in the architecture, engineering, and construction (AEC) industry. Building Information Modelling (BIM) is critical in boosting the productivity and quality of a building not only during design and construction stages but also includes post completion’s maintenance period. However, the majority of project stakeholders are still having difficulties in adopting BIM into practice, especially in the Sabah Construction Industry. In addressing the issues, the research aim is hence will analyze the challenges of adopting BIM and examine the Sabah state governments’ strategies that have been implemented to address the issues. The list of fourteen (14) BIM challenges that cover cost, process, people, technology were derived from a comprehensive literature review and further investigated through the use of 212 questionnaires distributed using online platform. The respondents were architects, engineers, and quantity surveyors.  It was revealed that among the top challenges highlighted are: people being comfortable with the conventional process, high software cost, as well as incompetent staff to operate the software. The Sabah state government has assisted with the implementation of BIM by offering standard guidelines and continuous financial support; however, the strategies provided by them were still not enough. The result of this study showed that the implementation of BIM in the construction project in Sabah is still below expectations. The awareness among construction players on how beneficial BIM is in assisting their daily project tasks should be further enhanced for better BIM implementation in the region. The outcomes of this study will hopefully provide some directions towards developing managerial strategies for the government to aggressively promote BIM practices among project stakeholders.
From a Necessary Being to a Perfect Being: A Reply to Byerly
Authors: Anderson Tina
Published: March 2022

Cosmological arguments for God typically have two stages. The first stage argues for a first cause or a necessary being, and the second stage argues from there to God. T. Ryan Byerly offers a simple, abductive argument for the second stage where the best explanation for why the being is found to have necessary existence is that it is a perfect being. The reasoning behind this argument is that universal generalizations explain observations of their instances; for example, the universal generalization that all ravens are black explains why some particular raven is observed to be black. Similarly, the fact that a being has all perfections explains why we find the being to have necessary existence. I distinguish between two readings of Byerly’s proposed theistic explanation, and conclude that his explanation does not offer an advantage to the theist in either case.
Vida cotidiana y trabajo en los diccionarios de términos marítimos: un aspecto de la Historia Social de trabajadores del mar hablantes de portugués
Authors: Rodrigues Jaime , Banin Jr. Fábio Rogério
Published: March 2022

El texto aborda el léxico de los marineros como rasgo distintivo de su cultura profesional. Asumiendo que los lenguajes son dinámicos y tienen sus propios procesos históricos, el principal objetivo fue demostrar aspectos de esta dinámica y algunas de las posibles fuentes para estudiarlos en los tiempos modernos y contemporáneos. Nos centramos principalmente en el Dicionário de Marinha del contralmirante portugués Carlos Diniz (1913), pero también cubrimos los diccionarios de marinería publicados en portugués en el siglo XIX, presentando rápidamente otros vocabularios existentes en fuentes de diferentes naturalezas y épocas.
Relaciones entre la agenda estatal y el reclutamiento de trabajadores marítimos en el Brasil del siglo XIX
Authors: Aguiar Thiago de Oliveira
Published: March 2022

El artículo tiene como objetivo discutir y presentar algunas reflexiones acerca de la agenda gubernamental del Imperio brasileño preocupada en organizar el Estado nacional a partir de las prácticas de alistamiento, reclutamiento y encuadre de varios sujetos que estuvieron en la mira de las instituciones militares a lo largo del contexto ochocentista.
Uma análise do perfil de trabalhadores da construção naval nos mapas estatísticos do Ministério da Marinha do Império do Brasil (1847-1875)
Authors: Schibelinski Diego
Published: March 2022

Pouco se sabe acerca dos sujeitos que atuaram na construção e manutenção de embarcaçãoes. Visando contribuir à superação de tal déficite, o artigo a seguir, ao produzir uma história vista de baixo, buscou compreender quem foramos trabalhadores que, no Brasil de meados do século XIX, atuaram no setor da construção naval como carpinteiros da ribeira e calafates. Para tanto, tomou-se como fonte principal um conjunto de mapas estatísticos, produzidos e publicados pelo Ministério da Marinha do Brasil entre os anos de 1847 e 1875, que recenseavam a força de trabalho empregada nas fainas marítimas em território nacional. Esses censos foram reunidos, transcritos e tabulados, permitindo a apreensão de informações relacionadas ao tamanho, configuração e variação de perfil dos grupos de trabalhadores que atuaram como construtores navais.
STUDENT’S READINESS TO CARRY OUT FACE-TO-FACE LEARNING AT KENDARI VOCATIONAL HIGH SCHOOL
Authors: Satrianta Hengki , Darmawansyah  , Kahar Linda
Published: March 2022

The slowing spread of Covid-19 infections has brought positive changes in the education sector. The issue of implementing limited face to face learning begins to excite students in gaining knowledge. Online learning effects for approximately two years was relatively difficult to keep students away from themselves. This study time to determine how the level of student learning readiness in facing offline learning. This was quantitative research with a survey type. The population were State vocatoonal high school 2 Kendari students, totaling 558 students. The sample was drawn randomly with a magnitude estimated using the Slovin formula at a significance of 5% so that the total sample size was 233 students. Data were collected by learning readiness scale. Data were analyzed descriptively and comparative statistics. The results showed that the learning readiness of State vocatoonal high school Negeri 2 Kendari students was in the high category and female students had a higher level of learning readiness than male students.
THE RELATIONSHIP BETWEEN SOCIAL NETWORK SITES AND SOCIAL ANXIETY AMONG UNIVERSITI PUTRA MALAYSIA UNDERGRADUATE STUDENTS.
Authors: Owunna Royal , Ajobi Alice , Ahamefule Angela , Emmanuel Fadero Oluwafemi
Published: March 2022

The study explore the relationship between social media communication and social anxiety among undergraduate students. The respondents were selected using a simple random technique. The data was collected by self-administered interview among 100 undergraduate students in Universiti Putra Malaysia. The Instruments used for data collection includes; Social Anxiety Questionnaire for Adults (SAQ-A30) and The Internet Addiction Test (IAT). Study revealed that Facebook was the most common social media patronized with 36 (36.70%) patronage, followed by Instagram with 33 (33.70%), WhatsApp 19 (19.40%) and finally Twitter with 10 (10.20%). Based on the respondents, most students use the social media for social communications and seeking information. The level of social anxiety among most undergraduate students of Human Ecology faculty in Universiti Putra Malaysia is high because approximately two third of the respondents possessed the higher score in social anxiety level.This implies that most undergraduate students of Universiti Putra Malaysia are up to date in information gathering and the use of social network has helped to facilitate social interaction among fellow students and friends thereby reducing the likelihood of students suffering social anxiety disorder.
ANALISIS SISTEM HASIL PRODUKSI PERTANIAN DENGAN MENGGUNAKAN METODE SIMPLE ADDITIVE WEIGHTING (STUDI KASUS: CV. MAREWA 45)
Authors: Wahyuni Sri , Faisal Faisal , M Munawarah
Published: March 2022

Rendahnya produktivitas kakao Indonesia menjadi salah satu kendala utama industri kakao nasional di samping rendahnya mutu. Mutu produk kakao yang dihasilkan dari perkebunan rakyat sangat rendah, tidak difermentasi, banyak mengandung kotoran dan jamur serta masih minimnya wawasan dan pengetahuan petani terhadap masalah manajemen produksi maupun pemasaran. Adapun tujuan dari penelitian ini adalah untuk merancang suatu sistem analisis hasil produksi pertanian yang memberikan informasi cara pengelolaan lahan yang benar agar dapat meningkatkan hasil produksi petani.Pada penelitian ini menggunakan jenis penelitian deskriptif kualitatif dengan menggunakan metode pengumpulan data yaitu wawancara, observasi dan studi literatur. Aplikasi ini di uji menggunakan black box, menggunakan bahasa pemrograman PHP dan MySQL.Dari Peneltian ini menghasilkan perancangan aplikasi Analisis Sistem Hasil Produksi Pertanian dengan Menggunakan Metode Simple Additive Weighting.  Dengan adanya aplikasi ini dapat memudahkan staf pegawai pada CV. Marewa serta dapat memberikan informasi cara pengelolaan lahan yang benar kepada petani untuk meningkatkan hasil produksinya.