bluuebunny/crossref_metadata_2025 huggingface dataset:
Utilidad clínica de la diferencia arterio–venosa de lactato como factor pronóstico de mortalidad en pacientes críticamente enfermos
Authors: Rodriguez-Yanez Tomas , Almanza Hurtado Amilkar , Martinez Avila Maria Cristina , Borré-Naranjo Diana , Montes-Farah Juan Manuel , Cuadrado Cano Bernarda , Ramos-Clason Enrique , Dueñas-Castell Carmelo
Published: March 2022

Introducción: La identificación temprana de hipoperfusión tisular es clave para guiar el manejo en pacientes en choque. El interés en obtener una valoración rápida y precisa de la perfusión tisular en el paciente crítico, ha llevado a estudiar diferentes productos metabólicos, sin embargo, ninguno satisface las necesidades sobre el enfoque y manejo de esta condición. La hiperlactatemia es un factor independiente de mortalidad y por ello, el desarrollo de parámetros como la diferencia arterio-venosa de lactato tendrían un valor agregado..Objetivo: evaluar la utilidad pronóstica de la diferencia arterio-venosa de lactato como predictor de mortalidad en pacientes críticamente enfermos.Métodos: estudio de prueba diagnóstica, realizado en las UCIs de la ESE Hospital Universitario del Caribe y Gestión Salud IPS, de enero/2017-enero/2018. Se tomaron muestras de gases arteriales-venosos centrales al ingreso, 12 y 24 horas de estancia en UCI. Se determinó el rendimiento diagnóstico del delta CO2, depuración arterial de lactato, lactato sérico y diferencia arterio-venosa de lactato como predictores de mortalidad.Resultados: se evaluaron 103 pacientes críticos, 49 fallecieron (47.5%). El choque séptico fue el estado más frecuente (57.2%). El delta de CO2 al ingreso mostró AUC de 0.53, el lactato de ingreso AUC 0.57, la depuración arterial de lactato exhibió un AUC de 0.52 y la diferencia arterio-venosa de lactato tuvo AUC de 0.50, con valores de p no estadísticamente relevantes.Conclusión: la diferencia arterio-venosa de lactato es un parámetro clínico con utilidad limitada para predecir mortalidad en la población global de pacientes ingresados a la UCI.
Síndrome de Kounis: una revisión exhaustiva
Authors: Bohórquez-Rivero José de Jesús , Polanco-Guerra Camilo , Gutiérrez-Baiz Carlos , Angulo-Ríos Katherine , Angulo-Ríos Karen , Torrens-Soto Jeison
Published: March 2022

Introducción: el síndrome de Kounis se ha establecido como un trastorno coronario asociado a reacciones alérgicas, de hipersensibilidad, anafilácticas y anafilactoides; que engloba conceptos como el de angina alérgica e infarto alérgico. Su incidencia ha sido difícil de establecer debido a que posee una gran cantidad de factores desencadenantes y que existen pocos registros en la literatura médica, de modo que no parece ser un síndrome raro sino una entidad clínica poco conocida, capaz de evolucionar fatalmente si no se reconoce y se trata de manera rápida.Objetivo: Resaltar y consolidar la literatura reciente sobre el síndrome de Kounis y así actualizar los conocimientos del médico en dicho tópico.Métodos: se realizó una revisión narrativa de la literatura encontrada en las bases de datos PubMed y Science Direct y en el motor de búsqueda Google Scholar utilizando las palabras claves. Se incluyeron artículos en idioma español e inglés publicados hasta el mes de agosto de 2021.Resultados: las reacciones alérgicas graves pueden desencadenar eventos coronarios agudos, esto se conoce como síndrome de Kounis. Se han descrito múltiples causas y sus manifestaciones clínicas pueden variar. La participación de los mastocitos cardíacos es fundamental en su desarrollo, a través de la liberación de múltiples mediadores que pueden desencadenar eventos agudos como vasoconstricción coronaria, rotura de placa ateroesclerótica y trombosis del stent coronario. Su diagnóstico se basa en las características clínicas, así como en pruebas de laboratorio, electrocardiográficas, ecocardiográficas y angiográficas. A pesar de que no existen guías de tratamiento para los pacientes con esta entidad, la literatura parece estar de acuerdo en que el manejo de dicha entidad en su fase aguda, debe involucrar el tratamiento del síndrome coronario agudo y la supresión de la reacción alérgica, teniendo en cuenta las interacciones y efectos de los fármacos a emplear.Conclusión: El síndrome de Kounis es un trastorno común y potencialmente mortal que se debe diagnosticar y tratar de forma idónea e inmediata; por tanto, el conocimiento de su epidemiología, etiología, patogenia y manifestaciones clínicas son importantes para su diagnóstico, y tratamiento. El clínico debe prestar especial atención ante cualquier reacción alérgica que preceda al evento cardíaco agudo y considerar el SK en el gabinete de diagnósticos diferenciales.
Políticas educativas en Nivel Medio Superior, de la calidad a la desigualdad
Authors: Reducindo Laredo Janet , de la Cruz Hernández Miriam , Ramírez Pérez Jorge Ariel
Published: March 2022

The objective of this paper is to show the way in which the educational policies implemented in Higher Secondary Education (EMS) in Mexico, led to the omission of the Federal High Schools for Cooperation (PREFECO for its acronym in Spanish) as a public subsystem. This omission had repercussions in the closure of schools and exacerbated the precarious working conditions of the teachers who work in that school subsystem. The paper analyzes the policies directed at the EMS during the 2008-2019 period in order to identify the causes that originated the main changes in the subsystem. The case of the PREFECO’s of the state of Morelos is contextualized and the labor conditions of their teachers. For the analysis of the official documents, some guidelines of the historical-descriptive method were retaken. To contextualize the conditions of the teachers, a questionnaire was applied and descriptive statistics were used for the analysis.
Efectos demográficos en los patrones de consumo en México: un análisis con microdatos para 2018
Authors: Galindo Paliza Luis Miguel , Francisco Cruz Carlos Alberto , Caballero Güendulain Karina
Published: March 2022

The objective of this article is to analyse the consumption patterns incorporating the demographic effects in Mexico using the ENIGH-2018. The main results show that the consumption patterns for different goods i can be specified as a function of total expenditure, of the demographic variables and the control variables such as economic and social characteristics. The demographic characteristics such as the number of members and children in the household affects the expenditure patterns of the household. For example, the proportion of expenditure in food and house with respect to total expenditure of the households is larger in households without children than with children and the proportion of expenditure with respect to total expenditure is larger in education and amusement in households with children than without children. Furthermore, the number of members and children modified the expenditure in food, education, housing, transport and clothes and the Engel expenditure elasticities indicate that food and clothes are necessary goods and education and amusement are, in general, luxury goods.
Bioingeniería de taludes: evaluación del uso de árboles y arbustos como posible mecanismo para incrementar el factor de seguridad
Authors: Grajales Saavedra Francisco , Vallarino Ruby , Mejía George , Centella Dylan
Published: March 2022

Diversos estudios han demostrado la influencia positiva de la vegetación en la estabilidad de los suelos, la cual genera un cambio significativo en las condiciones hidrológicas del suelo. Uno de los aportes más importantes de la vegetación es el que generan las raíces sobre la resistencia al corte del suelo; lo cual puede ser cuantificado mediante un aumento en la cohesión del suelo a través de una variable conocida como: “cohesión aparente o relativa”. Este artículo presenta una evaluación de los efectos positivos que pueden producirse mediante la inclusión de árboles y arbustos en la parte baja de taludes. Para esta investigación se realizó una revisión de literatura, consultas con expertos y se desarrolló una simulación numérica utilizando el método de los elementos finitos en dos dimensiones. Las simulaciones utilizan la cohesión aparente como la variable que define el aporte de las raíces a la cohesión del suelo. Se realizaron análisis de estabilidad en diferentes tipos de taludes donde se pudo cuantificar el factor de seguridad generado por los distintos valores de cohesión aparente y determinar la influencia de la profundidad de las raíces. Los resultados de esta investigación indican que existe un sustento para la consideración de árboles o arbustos como solución de bioingeniería para la estabilización de taludes y presenta recomendaciones basadas en las evidencias e información obtenidas.
Producción científica y su originalidad en universidades latinoamericanas: Una mirada en la Universidad Tecnológica de Panamá
Authors: Batista Libia , Muñoz María carla , Mosquera Rosa , González Víctor
Published: March 2022

El estudio del plagio u originalidad, con un enfoque orientado hacia la práctica en la producción científica de la universidad, permite a la comunidad académica establecer parámetros para la prevención y control de este flagelo y, por ende, proteger su imagen institucional como generadora de conocimiento científico. Este artículo presenta el estado del arte sobre el tema, mediante un proceso de análisis e investigación en treinta publicaciones que destacan la tipología, causas, buenas prácticas y la reglamentación universitaria relacionada al plagio en la producción científica, además de normativas en la Universidad Tecnológica de Panamá. Los estudios encontrados, en su mayoría de países como México y España, realizados en algunas universidades que han alzado su voz respecto al plagio, afloran avances importantes; además, revelan la falta de investigación sobre la práctica del plagio y la ausencia de mecanismos propios para su prevención, detección y control en países latinoamericanos. El estado del arte constituye el marco teórico adecuado para futuras investigaciones sobre este tema, lo cual implica el establecimiento y la justificación de nuevas líneas de investigación.
Distinct temperature stressors acting on multiple ontogenetic stages influence the biogeography of Atlantic blue crabs
Authors: Rogers TL , Gouhier TC , Kimbro DL
Published: March 2022

To understand and predict shifts in species distribution in a changing climate, it is important to consider the exposure and sensitivity of multiple life history stages, particularly for marine species with complex life cycles. In this study, we examined spatio-temporal trends in the abundance of the blue crab Callinectes sapidus and how different temperature stressors acting on multiple ontogenetic stages may affect the species’ current and future distribution across the Atlantic coast of the USA. Since 1975, crab abundance has remained constant or increased in the northeast and northern mid-Atlantic regions but declined in the southern mid-Atlantic and southeast. In the northeast, abundance changes and the location of the northern range boundary appear to be dictated primarily by lower thermal constraints on summer larval stages and may be reinforced by chronic winter cold stress on juveniles and adults. In the mid-Atlantic, acute winter cold stress on juveniles and adults may regulate crab abundance, whereas in the southeast, temperature stress is likely not limiting or directly driving abundance declines. Temperature projections suggest a potential for northward range expansion and increased abundance in the northeast. In the northern mid-Atlantic, however, changes in the duration, magnitude, and phenology of summer temperatures may have complex effects on crab reproduction. Our results highlight how past and future changes in environmental suitability can vary non-uniformly both within and beyond a species’ current range, and the value of examining multiple life history stages and aspects of temperature stress.
Diagnóstico de la inserción laboral de los egresados del grado universitario en Relaciones Laborales y Recursos Humanos de la Universidad de Sevilla
Authors: Martín López María del Milagro , González Limón Miryam , Rodríguez Ramos Asunción
Published: March 2022

La inserción laboral de los graduados universitarios es un problema de actualidad y un tema de vital importancia para el análisis de la calidad de la educación superior y de sus planes de estudios. Este novedoso tema se ha convertido en una de las principales preocupaciones de la sociedad actual. Entre los países europeos con tasas más altas de desempleo se encuentra España, junto a Grecia, Portugal e Italia. No obstante, es importante señalar que estas tasas van descendiendo en relación inversa al nivel educativo de la población. Este artículo tiene un doble objetivo, por un lado, analizar la inserción laboral de los egresados del Grado en Relaciones Laborales y Recursos Humanos de la Universidad de Sevilla de los cursos académicos 2013/2014, 2014/2015, 2015/2016 y 2016/2017 y, por otro lado, conocer si la formación recibida por su alumnado responde a las expectativas requeridas por el mercado laboral. Para cumplir con los objetivos propuestos, se ha diseñado un cuestionario estructurado con objeto de recabar información procedente de la totalidad de los egresados de los cursos académicos mencionados. Los ítems del cuestionario recogen información relativa a la duración de los estudios, el espacio de tiempo comprendido hasta que encontraron un empleo, así como el grado de satisfacción con las habilidades y competencias adquiridas a lo largo del periodo formativo, observando las diferencias desde una perspectiva de género. Entre los resultados obtenidos destacamos las importantes tasas de empleabilidad de los titulados en Relaciones Laborales.
Review: Potensi Tandan Kosong Kelapa Sawit sebagai Bahan Baku Pembuatan Bioetanol dengan Metode Fed Batch pada Proses Hidrolisis
Authors: Sindhuwati Christyfani , Mustain Asalil , Rosly Yasinta Octaliya , Aprijaya Andika Soharmat , Mufid Mufid , Suryandari Ade Sonya , Hardjono Hardjono , Rulianah Sri
Published: March 2022

Peningkatan kebutuhan energi terutama bahan bakar minyak yang tidak diimbangi dengan ketersediaan sumber energi tak terbarukan akan mengakibatkan kelangkaan energi. Pembuatan bahan bakar terbarukan merupakan solusi untuk mengatasi kelangkaan tersebut, salah satunya bioetanol. Biomassa Tandan Kosong Kelapa Sawit (TKKS) merupakan bahan baku yang cocok untuk pembuatan bioetanol karena jumlahnya yang melimpah dan mengandung lignoselulosa. Bioetanol dapat diperoleh melalui proses fermentasi dengan metode yang digunakan adalah Fed Batch Simultaneous Saccharification Fermentation. Pretreatment berupa size reduction dan delignifikasi direkomendasikan sebelum proses hidrolisis enzimatik dan fermentasi secara serentak. Metode pengumpanan Fed Batch pada High Total Solid Loading (HTSL) direkomendasikan sebagai strategi pengumpanan pada proses hidrolisis enzimatik dengan jumlah frekuensi yang tinggi memberikan hasil kadar etanol lebih tinggi.

The enhancement of energy needs, especially fuel, that is not complemented by the availability of non-renewable energy sources, would affect the deficient of energy. The production of renewable fuel such as bioethanol is a solution to overcome that deficiency. One of the substrates that are appropriate to be processed into bioethanol is Oil Palm Empty Fruit Bunch (OPEFB) because of abundant and lignocellulosic biomass. Bioethanol can be produced through the fermentation process by Fed-Batch Simultaneous Saccharification Fermentation method. Size reduction and delignification for pretreatment are recommended before the simultaneous enzymatic hydrolysis process and fermentation. Using the fed-batch as a feeding method of High Total Solid Loading (HTSL) is recommended for feeding strategy in hydrolysis enzymatic process with high frequency that can produce a higher yield of ethanol.
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS KEBUTUHAN SISWA BAGI GURU TPA BABUSSALAM BOGOR
Authors: Kosasih Fauzy , Juhana Juhana , Suratinah Suratinah , Riyanti Rahayu Dwi
Published: March 2022

Program pengabdian kepada masyarakat dengan judul “Pengembangan Media Pembelajaran Berbasis Kebutuhan Siswa bagi Guru TPA Babussalam Bogor” ini bertujuan untuk meningkatkan kemampuan guru Taman Pendidikan Al-Qur’an (TPA) Babussalam di Desa Cilebut Barat, Kabupaten Bogor, Jawa Barat dalam mengembangkan media pembelajaran yang sesuai dengan kebutuhan siswa. Kegiatan ini melibatkan mitra yaitu para guru dan siswa TPA Babussalam. Kegiatan telah dimulai dengan kunjungan awal untuk menganalisis situasi dan kebutuhan guru-guru di lokasi. Dari hasil kunjungan disepakati bahwa kegiatan ini difokuskan pada peningkatan kemampuan guru-guru dalam pengembangan media pembelajaran yang sesuai dengan kebutuhan siswa. Monitoring dan penilaian untuk menindaklanjuti hasil kegiatan Abdimas dilakukan di akhir kegiatan. Hasil kegiatan Abdimas ini menunjukkan bahwa setelah melalui kegiatan Abdimas, para guru mampu memahami teori dan teknik pengembangan media pembelajaran berbasis kebutuhan siswa.
PENGABDIAN MASYARAKAT MELALUI PHBS DENGAN PEMERIKSAAN KECACINGAN DAN HEMOGLOBIN PADA KELOMPOK SISWA SDN 01 CAWANG PAGI
Authors: Humaedi Aji , Kurniawan Muhammad Rizki
Published: March 2022

SDN Cawang 01 Pagi pada dasarnya telah menerapkan hidup bersih pada siswanya hal tersebut tercermin pada himbauan cuci tangan yang di pasang pada kelas-kelas, tersedianya tempat cuci tangan di depan kelas, tersedianya ruang UKS serta keterlibatan siswa dalam membersihkan kelas. Tetapi, banyak penjual jajanan di depan SDN Cawang 01 Pagi yang higienitasnya tidak terjamin, sehingga penyebaran penyakit khususnya kecacingan mudah terjangkit. Kegiatan pengabdian yang dilakukan adalah penyuluhan PHBS, pemeriksaan penyakit kecacingan, dan kadar hemogobin siswa/i SDN Cawang 01 Pagi. Pendekatan yang dilakukan  berupa edukasi perilaku hidup bersih dan sehat, pemeriksaan kemungkinan penyakit kecacingan dengan analisis sampel feses dan kadar hemoglobin. Hasilnya dari 73 siswa yang melakukan pemeriksaan, terdapat 3 siswa yang positif terinfeksi cacing. Gambaran hemoglobin siswa pada dasarnya normal dengan nilai rerata 13,3 g/dL.
PELATIHAN PENGEMASAN DAN PEMASARAN PRODUK UMKM MASYARAKAT DI DESA WATES KULON PROGO
Authors: Yudhanto Ferriawan , Anugrah Rinasa Agistya , Wijaya Oki
Published: March 2022

The government provides full support and facilities for UMKM in Wates Village, Kulon Progo Regency, to develop their business. The use of information technology is considered appropriate to be used as a solution in the marketing of the product. The purpose of this activity is to expand product marketing and create attractive packaging. The method was used is to provide counseling and training on product packaging and digital marketing. Marketing is the spearhead of a business, so it needs to be improved by utilizing existing technology or marketplaces. This activity shows that UMKM people more understand how to apply attractive packaging and used social media to support online marketing.

Pemerintah memberikan dukungan dan fasilitas bagi pelaku Usaha Mikro Kecil Menengah di Desa Wates Kabupaten Kulon Progo untuk terus mengembangkan usahanya. Pemanfaatan teknologi informasi dinilai tepat digunakan sebagai solusi dalam memperluas produk. Tujuan dari pengabdian ini untuk memperluas pemasaran produk dan membuat kemasan yang menarik. Metode yang digunakan adalah dengan memberikan penyuluhan dan pelatihan tentang pengemasan produk dan pemasaran digital. Pemasaran menjadi ujung tombak dalam suatu usaha, sehingga perlu ditingkatkan dengan memanfaatkan teknologi atau marketplace yang sudah ada. Hasil dari kegiatan ini yaitu para pelaku UMKM lebih memahami bagaimana cara mengaplikasikan kemasan yang menarik dan menggunakan media sosial dalam mendukung pemasaran secara online.
PENERAPAN GAYA BELAJAR AUDITORI TERHADAP PEMBELAJARAN AL-BARJANJI PADA SANTRI TPA AL-HIKMAH PUTRA SUMBERJO
Authors: Putri Wiwik Listiana Sari , Zuraidah Zuraidah
Published: March 2022

Learning to read and write the Qur’an properly and correctly cannot be done instantly, but must go through a process. So that in learning to read and write the Qur’an also requires an effective strategy to be applied by the Qur’an teaches in teaching his students. “Application of Auditory Learning Styles on Al-Barjanji Learning at the Students TPA Al-Hikmah Putra Sumberjo” is expected to be able to provide solutions to the problems faces by students and teachers of the Qur’an. The steps taken in the application of this auditory learning style are to teach the correct pronunciation of makhrajjul letters, then first read the book of Al-Barjanji to the students and the students imitate it. After that, the students recite the recitation to their Qur’an teachers and are assessed whether they are fluent and fluent in reciting Al-Barjanji. After the implementation of this learning style, it turned out to have an effect on the level of fluency an fluency of the students at TPA Al-Hikmah Putra Sumberjo. The students are getting more fluent and fluent in reciting Al-Barjanji and they get good assessments form their Qur’an teachers.

 

Belajar baca tulis Al-Qur’an yang baik dan benar tidak bisa dilakukan secara instan, melainkan harus melalui proses. Sehingga dalam belajar baca tulis Al-Qur’an pun memerlukan strategi yang efektif untuk diterapkan oleh guru mengaji dalam mengajari para santrinya. “Penerapan Gaya Belajar Auditori Terhadap Pembelajaran Al-Barjanji Pada Santri TPA Al-Hikmah Putra Sumberjo” ini diharapkan mampu memberikan solusi dari permasalahan yang dihadapi para santri dan guru mengaji. Langkah-langkah yang dilakukan dalam penerapan gaya belajar auditori ini adalah dengan mengajari pelafalan makhrajjul huruf yang benar, kemudian membacakan terlebih dahulu kitab Al-Barjanji kepada santri dan santri tersebut menirukannya. Setelah itu santri mengaji kepada ustadz atau ustadzahnya dan dinilai apakah sudah lancar dan fasih dalam mengaji Al-Barjanji. Setelah diterapkannya gaya belajar ini, ternyata berpengaruh terhadap tingkat kelancaran dan kefasihan santri-santri di TPA Al-Hikmah Putra Sumberjo. Para santri semakin lancar dan fasih dalam mengaji Al-Barjanji dan mereka mendapatkan penilaian yang baik dari para ustadz dan ustadzahnya.
PENGUATAN EKONOMI KERAKYATAN MELALUI PEMANFAATAN TEKNOLOGI TEPAT GUNA SOLAR PANEL DI DESA KURIPAN, CISEENG, BOGOR
Authors: Cahyadi Made Ayu Krisna , Purnama Rahmad , Tamjuddin Tamjuddin , Suhartono Suhartono , Nasoha Mohamad , Andriyansah Andriyansah
Published: March 2022

The lack of public street lighting (PJU) at several crucial points for social and economic activities is the main need for residents of Kuripan Village, Ciseeng, Bogor. Therefore, this community service program seeks to be directly involved in making improvements in the form of strengthening the people's economy. Improvements are made through appropriate technology with the installation of PJU sourced from solar panel. The limited use and utilization of PJU using solar panels is done because the maintenance costs are relatively cheap and can be carried out directly by the locals. Installation of PJU solar panels is carried out at two crucial points for social and economic activities. In addition, socialization in the form of training for the locals to assemble solar panel PJUs was also carried out. The benefits of installing solar panel PJUs at two crucial points are that it is easier for residents to carry out economic activities and also reduce criminal acts. The continuation of this program is so that in the future PJU solar panels can be developed to several points according to the needs of the residents.

 

Kurangnya penerangan jalan umum (PJU) pada beberapa titik krusial adanya aktivitas sosial dan ekonomi merupakan kebutuhan utama warga Desa Kuripan, Ciseeng, Bogor. Maka dari itu, progran pengabdian masyarakat ini berupaya untuk terlibat langsung dalam melakukan pembenahan berupa penguatan ekonomi kerakyatan. Pembenahan dilakukan melalui teknologi tepat guna dengan pemasangan PJU yang bersumber dari tenaga surya (solar panel). Terbatasnya penggunaan dan pemanfaatan PJU dengan menggunakan solar panel dilakukan karena biaya perawatan yang relatif murah serta dapat dilakukan langsung oleh warga setempat. Pemasangan PJU solar panel dilakukan di dua titik krusial adanya aktivitas sosial dan ekonomi. Selain itu, sosialisasi berupa pelatihan bagi warga setempat untuk perakitan PJU solar panel juga dilakukan. Manfaat dari pemasangan PJU solar panel di dua titik krusial adalah warga lebih mudah melakukan aktivitas ekonomi dan juga mengurangi adanya tindak kriminal. Kelanjutan dari program ini agar ke depannya PJU solar panel bisa dikembangkan ke beberapa titik sesuai kebutuhan warga.
KESEHATAN MASYARAKAT TERINTEGRASI MELALUI POSYANDU REMAJA DI DESA KABUBU
Authors: Nurliah Nurliah , Sagena Uni W
Published: March 2022

Posyandu remaja merupakan salah satu bentuk Upaya Kesehatan Bersumber Daya Masyarakat (UKBM) yang dikelola dan diselenggarakan dari, oleh, untuk dan bersama masyarakat termasuk remaja dalam penyelenggaraan pembangunan kesehatan, guna memberdayakan masyarakat dan memberikan kemudahan dalam memperoleh pelayanan kesehatan bagi remaja untuk meningkatkan derajat kesehatan dan keterampilan hidup sehat remaja. Sasaran pelaksanaan kegiatan Posyandu Remaja adalah remaja usia 10-18 tahun, laki-laki dan perempuan dengan tidak memandang status pendidikan dan perkawinan termasuk remaja dengan disabilitas. Sedangkan sasaran petunjuk pelaksanaan adalah petugas kesehatan, pemerintah desa, pengelola program remaja, keluarga dan masyarakat serta kader kesehatan remaja. Kegiatan ini merupakan salah satu program kerja KKN Individu dan dilaksanakan pada bulan 4 Juli-14 Agustus 2021 di Desa Kabubu, Kecamatan Topoyo, Kabupaten Mamuju Tengah,Provinsi Sulawesi Barat. Metode  pelaksanaan meliputi sosialisasi melalui pendekatan internal dengan petugas kesehatan dan pendekatan eksternal kepada pihak desa, lalu mengumpulkan beberapa remaja aktif dan diminta kesediaannya menjadi pengurus di Posyandu Remaja. Hasil dari kegiatan ini adalah terbentuknya Kader Kesehatan Remaja di Desa Kabubu sehingga berdampak keaktifan remaja dan tumbuhnya pemahaman remaja tentang  kesehatan tubuh dan mental yang terintegrasi. Hal ini tentunya dapat meningkatkan derajat kesehatan remaja di Desa Kabubu.
OPTIMALISASI DIGITAL MARKETING UNTUK PENGUATAN IRT TEH BUNGA TELANG PENUNJANG MITIGASI PANDEMI AGROWISATA LERENG MERAPI, KABUPATEN SLEMAN
Authors: Anggraini Oktiva , Indrayana Masrul , Supriyanta Supriyanta
Published: March 2022

Masa pandemi Covid 19 telah mengubah tatanan kehidupan masyarakat. Sebagai industri rumah tangga yang terpapar pandemi, anggota KWT Kemiri Edum kesulitan dalam memasarkan produk akibat pembatasan sosial guna mencegah penularan virus Corona. Tim PKM UWM melalui Program Kemitraan Masyarakat berupaya menyelesaikan masalah mitra KWT Kemiri Edum di desa Purwobinangun, lereng Merapi, kabupaten Sleman. Permasalahan mitra yang menjadi titik perhatian: aksesibilitas terhadap teknologi informasi terbatas; rendahnya pemahaman mitra terhadap marketing mix dan digitalisasi produk. Di samping itu, pemasaran konvensional, penggunaan pemasaran online terbatas, penyajian konten promosi mitra kurang menarik dan persuasif. Sejumlah referensi pendukung tentang pentingnya digitalisasi produk kreatif dapat menjadi solusi dalam pemasaran IRT bunga telang dari KWT Kemiri Edum. Program aksi yang dilakukan: Pertama, pelatihan teknologi informasi, pelatihan digitalisasi produk kreatif daerah dan penyuluhan potensi agrowisata bunga telang berbasis community based tourism penunjang mitigasi pandemi lereng Merapi. Metode yang digunakan dalam kegiatan ini antara lain metode PRA, ETB dan TI dengan teknik sosialisasi, edukasi atau penyuluhan, implementasi teknologi dan pendampingan. Serangkaian aksi bermakna ini diikuti pemberian fasilitasi alat dan monev serta evaluasi mengacu pada indikator pencapaian setiap kegiatan. Hasil PKM menunjukkan, mitra makin bertambah pengetahuan untuk memanfaatkan teknologi informasi sebagai media etalase penjualan produk secara online melalui IG, Youtube, Twitter dan Facebook; bertambahnya jalinan kerjasama mitra dengan stakeholder usaha yakni jumlah biro tour, hotel dan pusat oleh-oleh. Rangkaian kegiatan mampu mengubah pola pikir perilaku mitra dalam pemasaran dengan memperluas jaringan usaha ditopang bauran pemasaran online dan konvensional. memproduksi dan menjual produk agar mampu mendapatkan omzet lebih besar. Mitra memahami standar prosedur pengelolaan  desa wisata  dengan tatanan Era New Normal menuju Quality Tourism. Luaran PKM: Artikel ilmiah yang dipublikasikan melalui Jurnal Nasional; satu artikel pada media cetak/elektronik; rekaman video kegiatan dan peningkatan keberdayaan mitra/rekayasa sosial.
IMPLEMENTASI PENGGUNAAN BUKU PANDUAN PEMBELAJARAN DAN PENILAIAN ADAPTIF PADA JENJANG SMP
Authors: Ramdani Zulmi , Amri Andi , Warsihna Jaka , Anas Zulfikri , Chandra Didi Teguh , Hadiyana Deni , Nurwiansyah Irwan
Published: March 2022

Perubahan yang terjadi secara tiba-tiba membuat seorang guru khawatir dan cemas untuk melaksanakan pembelajaran di sekolah. Bahkan beberapa dari mereka kesulitan untuk melaksanakan pembelajaran sebagaimana biasanya. Kegiatan pengabdian ini dilakukan dengan melakukan sosialisasi, implementasi dan evaluasi buku panduan pembelajaran dan penilaian adaptif yang dikembangkan tim pengabdian. Buku panduan pembelajaran dan penilaian adaptif digunakan sebagai petunjuk bagi guru SMP untuk melaksanakan pembelajaran sistem dimana saja, kapan saja dan dalam situasi apa saja. Terdapat empat wilayah di Indonesia yang menjadi lokasi kegiatan pengabdian, yaitu Garut, Bandung, Batam dan Surakarta. Kegiatan dilakukan selama 3 hari, dimana hari pertama tim melakukan sosialisasi buku panduan, hari kedua tim melakukan pemanfaatan buku panduan di sekolah terpilih dan hari ketiga tim melakukan evaluasi secara online terkait buku panduan yang sudah digunakan. Hasil kegiatan pengabdian menunjukkan bahwa menurut para guru, buku panduan ini sangat penting dimiliki oleh mereka dan bisa menjadi alternatif panduan ketika mereka kesulitan dalam melaksanakan pembelajaran yang terbatas. Kegiatan pengabdian ini juga mendapatkan informasi tentang kekhasan masing-masing sekolah dengan daerah yang berbeda dalam melaksanakan pembelajaran dan penilaian adaptif.
Dragonslayer – musical composition and mythical thought
Authors: Irlandini Luigi Antônio
Published: March 2022

A obra Vṛtrahan (2017), de XXXX, para saxofone barítono e percussão, cria uma nova relação entre pensamentos musical e mítico, assim como muitas outras composições do autor desde 1988. Nesta peça, o mito védico de Indra matando o Dragão Cósmico Vṛtra sugere procedimentos estruturantes, fontes sonoras instrumentais e imagens sonoras, resultando numa congruência entre música e mito muito maior do que uma simples relação programática. A discussão de alguns processos composicionais desta obra, conforme foram sugeridas pelo pensamento mítico, ilustra a ideia do autor de composição como cosmologia.
Some compositional approaches in the practice of live-electronic music from the perspective of technique and technological tools
Authors: Cesar de Oliveira Vinícius , P. Pessanha Thales Roel
Published: March 2022

As ferramentas e seus arcabouços técnicos impactam diretamente nos processos composicionais, colocando-se assim como elementos de fundamental importância, seja na concepção de ideias e imagens poéticas, seja na realização técnica de uma obra. Nesse sentido, o presente trabalho tem como objetivo discutir alguns aspectos da correlação entre técnica, poética, estética e escrita musical no contexto da live-electronics e da música interativa. Isso se dá a partir de um diálogo entre ideias de autores e compositores, como Gilbert Simondon e Helmut Lachenmann acerca dos arcabouços técnicos e suas implicações na prática musical. Assim, pretendemos discutir a inter-relação entre imagens poéticas, objetos técnicos e realizações técnico-musicais que se estabelecem no processo composicional. Essas reflexões servirão de campo teórico para apresentar e descrever algumas características gerais do pensamento composicional a partir de alguns exemplos de peças do repertório e de estratégias individuais empregadas em duas peças específicas: Espasmos (2017), para trombone e live-electronics, de Vinícius César, e "Caminhos que me Levam" (2018), para clarinete e live-electronics, de Thales Roel.
Plant Growth Promoting Actinobacteria, the Most Promising Candidates as Bioinoculants?
Authors: Boukhatem Zineb Faiza , Merabet Chahinez , Tsaki Hassini
Published: March 2022

Plant Growth Promoting Bacteria (PGPBs) are a strong ally for sustainable agriculture. They offer an interesting alternative to chemical fertilizers and pesticides. Many microorganisms have been widely documented for their PGPR traits, but actinobacterial microbes which have been increasingly documented only these two past decades for their ability to promote plant growth. Their action on plant health and yield could be either direct, indirect or both. This review will cover articles that have been published on Actinobacteria PGP traits, highlighting the involved mechanisms to reveal their strong potential as microbial fertilizers. Possible strategies to encourage Actinobacteria use as bioinoculants are also discussed.
A Novel Framework for the Identification of Reference DNA Methylation Libraries for Reference-Based Deconvolution of Cellular Mixtures
Authors: Bell-Glenn Shelby , Thompson Jeffrey A. , Salas Lucas A. , Koestler Devin C.
Published: March 2022

Reference-based deconvolution methods use reference libraries of cell-specific DNA methylation (DNAm) measurements as a means toward deconvoluting cell proportions in heterogeneous biospecimens (e.g., whole-blood). As the accuracy of such methods depends highly on the CpG loci comprising the reference library, recent research efforts have focused on the selection of libraries to optimize deconvolution accuracy. While existing approaches for library selection work extremely well, the best performing approaches require a training data set consisting of both DNAm profiles over a heterogeneous cell population and gold-standard measurements of cell composition (e.g., flow cytometry) in the same samples. Here, we present a framework for reference library selection without a training dataset (RESET) and benchmark it against the Legacy method (minfi:pickCompProbes), where libraries are constructed based on a pre-specified number of cell-specific differentially methylated loci (DML). RESET uses a modified version of the Dispersion Separability Criteria (DSC) for comparing different libraries and has four main steps: 1) identify a candidate set of cell-specific DMLs, 2) randomly sample DMLs from the candidate set, 3) compute the Modified DSC of the selected DMLs, and 4) update the selection probabilities of DMLs based on their contribution to the Modified DSC. Steps 2–4 are repeated many times and the library with the largest Modified DSC is selected for subsequent reference-based deconvolution. We evaluated RESET using several publicly available datasets consisting of whole-blood DNAm measurements with corresponding measurements of cell composition. We computed the RMSE and R2 between the predicted cell proportions and their measured values. RESET outperformed the Legacy approach in selecting libraries that improve the accuracy of deconvolution estimates. Additionally, reference libraries constructed using RESET resulted in cellular composition estimates that explained more variation in DNAm as compared to the Legacy approach when evaluated in the context of epigenome-wide association studies (EWAS) of several publicly available data sets. This finding has implications for the statistical power of EWAS. RESET combats potential challenges associated with existing approaches for reference library assembly and thus, may serve as a viable strategy for library construction in the absence of a training data set.
Ferroptosis Patterns and Tumor Microenvironment Infiltration Characterization in Bladder Cancer
Authors: Xia Qi-Dong , Sun Jian-Xuan , Liu Chen-Qian , Xu Jin-Zhou , An Ye , Xu Meng-Yao , Liu Zheng , Hu Jia , Wang Shao-Gang
Published: March 2022

Background: Ferroptosis is a unique iron-dependent form of cell death and bladder cancer (BCa) is one of the top ten most common cancer types in the world. However, the role of ferroptosis in shaping the tumor microenvironment and influencing tumor clinicopathological features remains unknown.

Methods: Using the data downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), we comprehensively evaluated the ferroptosis patterns of 570 BCa samples based on 234 validated ferroptosis genes reported in the FerrDb database and systematically correlated these ferroptosis patterns with tumor microenvironment (TME) cell-infiltrating characteristics. The ferroptosis score was constructed to quantify ferroptosis patterns of individuals using principal component analysis (PCA) algorithms.

Results: Four distinct ferroptosis patterns and two gene clusters were finally determined. Significant differences in clinical characteristics and the prognosis of patients were found among different ferroptosis patterns and gene clusters, so were in the mRNA transcriptome and the landscape of TME immune cell infiltration. We also established a set of scoring system to quantify the ferroptosis pattern of individual patients with BCa named the ferroptosis score, which was discovered to tightly interact with clinical signatures such as the TNM category and tumor grade and could predict the prognosis of patients with BCa. Moreover, tumor mutation burden (TMB) was positively correlated to the ferroptosis score, and the low ferroptosis score was related to a better response to immunotherapy using PD-1 blockade. Finally, we also found there existed a positive correlation between the sensitivity to cisplatin chemotherapy and ferroptosis score.

Conclusions: Our work demonstrated and interpreted the complicated regulation mechanisms of ferroptosis on the tumor microenvironment and that better understanding and evaluating ferroptosis patterns could be helpful in guiding the clinical therapeutic strategy and improving the prognosis of patients with BCa.
Up-Converting Nanocrystals Modified With Fluorescent Markers for the Detection of Amino Acids: Preparation, Characterization, and Sensing Performance
Authors: Fei YuLang , Wu Kun , Liu Liang
Published: March 2022

The present work was devoted to developing rhodamine-like chemosensing systems for cysteine (Cys) optical recognition. Aiming at low background light and minimal photobleaching effect, up-converting nanocrystals were firstly synthesized and latterly coated by α-cyclodextrin, and finally used as an exciting host. An energy transfer procedure from these nanocrystals and rhodamine sensors was established via their spectroscopic analysis and emissive decay dynamics comparison. The binding dynamics of our chemosensors for Cys were revealed to have uncomplicated recognition with a stoichiometric ratio of 1 vs. 1. The addition of cysteine increased the emission intensity of the chemosensors. As a consequence, the luminescence off-on effect with sensing selectivity and linear sensing behavior for Cys was demonstrated. Sulfur modification on our chemosensors was shown to be effective in improving their selectivity and photostability.
AngioJet Rheolytic Thrombectomy to Treat Inferior Vena Cava Filter-Related Thrombosis: Efficacy and Safety Compared With Large-Lumen Catheter Suction
Authors: Liu Zhengli , Fu Guanqi , Gong Maofeng , Zhao Boxiang , Gu Jianping , Wang Tao , Zhou Yangyi , He Xu , Kong Jie
Published: March 2022

Objective

To compare the efficacy and safety of AngioJet rheolytic thrombectomy (ART) and large-lumen catheter suction (LCS) in the treatment of inferior vena cava (IVC) filter related IVC-iliac vein thrombosis.

Methods

The clinical data and medical imaging materials of 65 cases were collected, which suffered acute inferior vena cava filter related IVC-iliac vein thrombosis and received percutaneous mechanic thrombectomy (PMT) from June 2016 to June 2020 in our center, including 32 cases of LCS group and 33 cases of ART group. The final thrombolysis rate, the incidence of complications, and the follow-up are evaluated.

Results

The limb swelling was significantly relieved in patients with PMT after treatment. The peri-diameter difference of the limb in the LCS group before and after treatment was [(5.20 ± 2.03) vs. (2.17 ± 1.29) cm, P < 0.05], and that in the ART group before and after treatment was [(4.79 ± 2.23) vs. (1.74 ± 0.94) cm, P < 0.05]. The amount of postoperative recombinant tissue-type plasminogen activator (rt-PA) is reduced in ART group [(57.97 ± 21.25) in LCS group vs. (40.45 ± 20.89) mg in ART group, P < 0.05], and the thrombolysis rate was higher than that of the LCS group [(74.13 ± 19.74% in LCS group) vs. (84.58 ± 11.90% in ART group %), P < 0.05]. No serious complications occurred during the treatment.

Conclusion

Both LCS group and ART group have good thrombosis clearance effects on the inferior vena cava filter related IVC-iliac vein thrombosis. ART can reduce the rt-PA dose, increase the thrombolysis rate and reduce the risk of bleeding during thrombolysis.
3D Geomechanical Modeling and Prediction of Fractures in the Bozi Ultra-Deep Gas Field in the Kuqa Depression of Tarim Basin
Authors: Xu Ke , Zhang Hui , Wang Haiying , Wang Zhimin , Yin Guoqing , Wang Xiaoxue , Kang Tingting , Huang Li , Wang Zhaohui , Zhao Wei
Published: March 2022

In order to clarify the fracture distribution characteristics of the Bozi gas field in the Kuqa Depression, based on the statistics of fracture parameters from core data and imaging logging, the three-dimensional (3D) structural model of the complex thrust structure is established by using the voxel-based morphometry (VBM) structural framework modeling technology; the 3D heterogeneous rock mechanics field in the study area is constructed by well-to-seismic integration. The relationship between in situ stress field and fracture parameters is established under the consideration of rock fracture criterion, and fracture prediction of the Cretaceous reservoir in the Bozi gas field is carried out with the finite element numerical simulation method. Considering the influence of in situ stress field on fracture parameters, fracture activity is analyzed. The results show that the Cretaceous reservoirs in the Bozi gas field generally develop fractures, most of which are high-angle shear fractures of tectonic origin and are semi-filled or unfilled. The fracture distribution of the Bozi gas field is obviously controlled by local structures such as folds and faults. From north to south, the fracture development gradually weakens, and the fracture density of Bozi 104 and Bozi 102 fault blocks in the north is the highest. The fracture in the northern fault block of the Bozi gas field shows high activity, while that in the southern fault block shows low activity. The fractures in the higher structural parts of most fault blocks show high activity.
Accommodating Students With Special Educational Needs During School Closures Due to the COVID-19 Pandemic in Norway: Perceptions of Teachers and Students
Authors: Cameron David Lansing , Matre Marianne Engen , Canrinus Esther Tamara
Published: March 2022

The purpose of the two interrelated studies reported here was to explore the approaches that schools and teachers adopted to accommodate students with special educational needs (SEN) during school closings in Norway, as well as the consequences of the pandemic for children with SEN and their peers. Study 1 was a mixed-methods case study of a lower-secondary school in which students with SEN (n= 14) and students performing at or above grade-level (n= 66) completed a survey about their experiences. Survey results were then used as a starting point for follow-up interviews with four teachers and the school principal to explore how they dealt with pandemic restrictions and supported students with SEN. Study 2 is based on a survey of teachers from 10 schools (n= 128) who were participating in a professional development course on the use of educational technology when pandemic restrictions were enacted. Findings from both studies indicate that teachers and pupils are most concerned about the social and emotional consequences of the pandemic and report that distance learning worked poorly for pupils with SEN. For this reason, many students with SEN were provided with teaching at school while their classmates remained at home. Overall, teachers and students believe that they coped well given the circumstances and that the long-term impact on most students will be minimal. However, findings from both studies point to areas of concern for students with SEN and other pupils who were already struggling prior to the shutdown, citing a failure to meet the needs of these students through digital home-schooling and a loss of the support that students have a legal right to receive.
Grading Central Diabetes Insipidus Induced by Immune Checkpoint Inhibitors: A Challenging Task
Authors: Barnabei Agnese , Strigari Lidia , Corsello Andrea , Paragliola Rosa Maria , Iannantuono Giovanni Maria , Salvatori Roberto , Corsello Salvatore Maria , Torino Francesco
Published: March 2022

Central diabetes insipidus (CDI) is a rare endocrine disease deriving from an insufficient production or secretion of anti-diuretic hormone. Recently, CDI has been reported as a rare side effect triggered by immune checkpoint inhibitors (ICI) in cancer patients. Despite its current rarity, CDI triggered by ICI is expected to affect an increasing number of patients because of the expanding use of these effective drugs in a growing number of solid and hematologic malignancies. An appropriate assessment of the severity of adverse events induced by anticancer agents is crucial in their management, including dosing adjustment and temporary withdrawal or discontinuation treatment. However, assessment of the severity of CDI induced by ICI may be challenging, as its main signs and symptoms (polyuria, dehydration, weight loss, and hypernatremia) can be incompletely graded. Indeed, the current grading system of toxicity induced by anticancer treatments does not include polyuria. Additionally, dehydration in patients affected by diabetes insipidus, including ICI-induced CDI, is different in certain aspects from that due to other conditions seen in cancer patients, such as vomiting and diarrhea. This prompted us to reflect on the need to grade polyuria, and how to grade it, and to consider a specific grading system for dehydration associated with CDI induced by ICI. Here we propose a new grading system for polyuria and dehydration, as critical symptoms of the CDI syndrome occurring in patients on ICI treatment, to obtain better management of both the adverse event and the triggering drugs.