bluuebunny/crossref_metadata_2025 huggingface dataset:
Entrepreneurial orientation and product innovation. The moderating role of family involvement in management.
Authors: Fredyna Taras , Ruiz Palomo Daniel , Dieguez Soto Julio
Published: May 2020

In this current research it has been examined, firstly, the Entrepreneurial orientation in relation with Product innovation, Incremental innovation and Radical innovation, and, secondly, the moderating effect of Family involvement in the management of companies in the relationship between Entrepreneurial orientation and Product innovation, Incremental innovation and Radical innovation. Using a sample of 634 Spanish family firms, the results found conclude that the Entrepreneurial orientation has a positive effect on Product innovation, Incremental innovation and Radical innovation, and moreover, they reveal that the Family involvement in the management of companies has a moderating effect on these relations, witnessing that family firms with higher scale of Family involvement in the management of the companies reduces the effect of Entrepreneurial orientation on Product innovation, Incremental innovation and finally, Radical innovation.
Mortality rate and prognostic factors for dogs with severe anaphylaxis: 67 cases (2016–2018)
Authors: Smith M. Ryan , Wurlod Virginie A. , Ralph Alan G. , Daniels Erin R. , Mitchell Mark
Published: May 2020

OBJECTIVE

To determine mortality rates for dogs with severe anaphylaxis and identify potential prognostic factors.

ANIMALS

67 dogs with suspected anaphylaxis graded as severe.

PROCEDURES

Dogs were classified on the basis of outcome as survivors and nonsurvivors. Medical records were reviewed, and data were extracted including signalment, examination findings, time to hospital admission from onset of clinical signs, CBC results, serum biochemical analysis results, coagulation testing results, and findings on abdominal ultrasonography. Initial treatment within the first 6 hours after hospital admission was recorded for analysis, specifically including the use of epinephrine, diphenhydramine, corticosteroids, antimicrobials, fresh-frozen plasma, and supplemental dextrose.

RESULTS

The overall mortality rate was 14.9% (10/67) for dogs with anaphylaxis graded as severe. Serum phosphorus concentration and prothrombin time (PT) were significantly higher in nonsurvivors, compared with survivors. Nonsurvivors had lower presenting body temperatures than survivors. Serum phosphorus concentration ≥ 12.0 mmol/L, hypoglycemia within 6 hours after hospital admission, high PT value, concurrently high PT and partial thromboplastin time (PTT) values > 50% above the reference range limit, and the need for supplemental dextrose were associated with death. The incidences of coagulopathy and peritoneal effusion were unexpectedly high (85.2% and 65.5% of dogs, respectively) but were not indicative of survival.

CONCLUSIONS AND CLINICAL RELEVANCE

Despite the poor presenting clinical condition seen in dogs with severe anaphylaxis, the rate of survival with treatment was fairly high. Coagulopathy and the presence of peritoneal effusion were common findings in dogs with severe anaphylaxis. Serum phosphorus concentration ≥ 12.0 mmol/L, high PT value, concurrent increases of PT and PTT values > 50% above reference range limits, hypoglycemia within 6 hours after hospital admission, and the need for supplemental dextrose were associated with death.
Diagnosis and long-term management of post-traumatic seizures in a white-crowned pionus (Pionus senilis)
Authors: Kabakchiev Claudia , Laniesse Delphine , James Fiona , zur Linden Alex , Brouwer Emily , Beaufrère Hugues
Published: May 2020

CASE DESCRIPTION

A 13-year-old female white-crowned pionus (Pionus senilis) was examined because of seizures 22 months after it was treated for a traumatic brain injury (TBI) characterized by vision loss, hemiparesis, nystagmus, circling, and head tilt.

CLINICAL FINDINGS

Bloodwork performed during the initial seizure workup revealed hypercalcemia and hypercholesterolemia, which were attributed to vitellogenesis given the bird's previous egg-laying history and recent onset of reproductive behavior. Magnetic resonance imaging of the brain revealed diffuse right pallium atrophy with multifocal hydrocephalus ex vacuo, which were believed to be the result of the previous TBI. Findings were most consistent with post-traumatic seizures (PTS).

TREATMENT AND OUTCOME

Levetiracetam (100 mg/kg [45 mg/lb], PO, q 12 h) was initiated for PTS management. A 4.7-mg deslorelin implant was injected SC to suppress reproductive behavior. The bird was reexamined for presumed status epilepticus 5 times over 22 months. Seizure episodes coincided with onset of reproductive behavior. The levetiracetam dosage was increased (150 mg/kg [68 mg/lb], PO, q 8 h), and zonisamide (20 mg/kg [9.1 mg/lb], PO, q 12 h) was added to the treatment regimen. Additional deslorelin implants were administered every 2 to 6 months to suppress reproductive behavior. The owner was trained to administer midazolam intranasally or IM as needed at home. The treatment regimen helped control but did not eliminate seizure activity. The bird was euthanized 22 months after PTS diagnosis for reasons unrelated to the TBI or PTS.

CLINICAL RELEVANCE

Long-term management of PTS in a pionus was achieved with levetiracetam and zonisamide administration.
The impact of different navigation speeds on cybersickness and stress level in VR
Authors:   University of Zagreb, Faculty of Graphic Arts, Croatia, Agić Ana , Murseli Ella ,   University of Zagreb, Faculty of Graphic Arts, Croatia, Mandić Lidija ,   University of Zagreb, Faculty of Graphic Arts, Croatia, Skorin – Kapov Lea ,   University of Zagreb, Faculty of Electrical Eingeneering and computing, Croatia
Published: May 2020

The aim of this research was to determine if the speed of movement in virtual environments has an impact on cybersickness as potentially experienced by an end user of the system. Cybersickness is a common side effect in virtual reality (VR) systems, shown to have a negative influence on user experience. It can be described as a mismatch between vestibular and oculomotor sensors, where a person has a feeling of movement even though there is none. In this research, we study the impact of different navigation speeds in VR on cybersickness, relying on both subjective ratings indicating cybersickness symptoms, and objective measures of stress level. We wanted to find out if there is a correlation between objective and subjective metrics used. For test purposes, we used the HTC Vive VR headset and scenery from the Talos Principle VR game (where subjects can easily shift between three different movement speeds). Subjective ratings were collected using a questionnaire involving 11 questions used to evaluate cybersickness symptoms. Objective metrics were collected using the Pip Biosensor. A total of 28 participants took part in the study, while 2 participants withdrew due to physical discomfort. Results obtained from the Pip device show no statistically significant difference between navigation speeds for relaxed, stressed, and steady states. Some statistically significant correlations were found between gender and stomach ache, need to vomit, and physical discomfort while wearing HMD. Furthermore, correlation was found between age and variables of nausea in transport vehicles and vertigo. Other correlations found are described in the results section of the paper.
Na gestualidade de professoras e bebês, o corpo fala de relações
Authors: Bonfim Patrícia Vieira , Ostetto Luciana Esmeralda
Published: May 2020

O corpo é materialidade, substância viva, pulsante, mediadora das relações humanas e, neste trabalho, ocupa o centro da discussão. Ao buscar pelas relações corporais tecidas entre professoras de Educação Infantil e bebês, em uma pesquisa de doutorado em andamento, os dados foram gerados por meio de observações em uma creche pública do interior mineiro. Nas observações, produziram-se sequências fotográficas, focando momentos de contato corporal entre adultos e bebês, ao longo do cotidiano educativo. Posteriormente, algumas sequências foram apreciadas e discutidas em encontros com as professoras participantes da pesquisa. Alguns dos resultados evidenciaram tipologias de movimentos relacionais aproximados, identificados nos gestos desenhados entre bebês e adultos. As imagens recolhidas revelam também a necessidade de mais tempos e de espaços ao ar livre para potencializar experiências de corpos expandidos, que olham para Si e para o Outro, dialogando, produzindo sentidos com a/na natureza.
In the gestuality of teachers and babies, the body talks of relationships
Authors: BONFIM Patrícia Vieira , OSTETTO Luciana Esmeralda
Published: May 2020

With the body, the individual suspects the world, affects and is affected by it, builds relationships, signifies and expresses existence. What do the bodies of babies and adults say about each other? Based mainly on Wallonian Psychology and Lebretonian Anthropology, this article presents partial results of a doctoral research that aims to analyze narratives about/with the body woven in the interactions between teachers and babies. The data, resulting from the observation of a group of babies with their teachers, were generated through written and photographic records, focusing on different moments of the routine, later appreciated and discussed in meetings with the teachers. For the analysis presented here, relational movements composed by the gestures produced between babies and teachers were observed in the environment outside the reference room. It was preliminarily noted that the quality of the relationship established between them was fundamental to activate the discovery of the body, in the experimentation of space, textures, shapes and flavors.
Methodological reflections on the historiography of the student movement
Authors: SUCUPIRA Tânia Gorayeb , GARCÍA DELGADO Francisco Javier
Published: May 2020

If scientific methodology is tasked with improving the investigation of issues, the analysis of studies enshrined in the Social Sciences field shows gaps that, once filled, would expand the view on the phenomenon. Thereare studies that emphasize the description of narratives, actors and events, to the detriment of processes structured throughout a long period, such as the nuances of culture and subjectivism. This study consisted of areview based on publications about the student movement in 1968 in Colombia, Mexico and Brazil. The hypothesis validates the repeated analytical standard, but presumes that it is possible to improve the record of the phenomenon. The review of scientific literature identifies causes, factors and elements involved in the processes. Among the results, common variables that interconnect in political movements: actor profile, contexts, event dynamics, communicational aspects and institutional aspects.
Notas para problematizar la ética de sí en la educación del cuerpo
Authors: Rodríguez Norma Beatriz , Bustos Liliana
Published: May 2020

La creación de la escuela moderna a finales del siglo XIX trajo consigo la formación de una disciplina ocupada de educar el cuerpo. Fue en ese momento constitutivo en donde se delimitaron las prácticas corporales para los hombres: ejercicios militares, fuerza, virilidad, posturas; mientras que para las mujeres se esperaba: perfección de la feminidad, danza, gimnasia rítmica. De la perpetuación de estos estereotipos en la clase de Educación Física deriva la hipótesis de la investigación que presentamos que es la influencia directa y condicionada de las prácticas culturales en relación a la expresión de género queda reducida al análisis respecto de la condición de sexo leído en clave de lo que es biológicamente atribuido. Como marco teórico recurrimos a los aportes de la Teoría Queer y, por otro lado, analizamos las normativas vigentes para el Sistema Educativo Argentino tomando especial referencia en la Ley de Educación Sexual Integral de la Argentina. El trabajo de campo se realizó durante el año 2018 en dos escuelas de nivel primario de administración pública, situadas en las ciudades de Almafuerte y Rio Tercero de la provincia de Córdoba, Argentina.
Students’ experience of critical situations associated with studying: philosophical-psychological analysis
Authors: Zvonova Ekaterina Evgen'evna
Published: May 2020

The object of this research is the critical situation that has emerged and develops due to studying; the subject is its experiencing by the students. The article provides related to romanticization of cognition and suggesting self-transcendence version of establishing semantic correlation between consciousness and being of a student in the indicated critical situation for the purpose of increasing the meaningfulness of life. Its realization would allow achieving the synthesis of intelligence and affect in education, unity of education and upbringing due to acquisition of ethical meaning. Research methodology is based on the achievements of logotherapy, namely the principle of indererminism of human existence and humanistic psychology. The scientific novelty consists in the analysis of critical situations related to studying, which have not been previously viewed from the existential perspective, in the context of the theme of existential crisis. The article also proposes an original method for overcoming critical situations through romanticization of cognitive activity.
Pembentukan Karakter Murid (Studi terhadap Sekolah Dasar Islam Terpadu Al-Fityah Pekanbaru)
Authors: Yunita Yenni
Published: May 2020

Character education is essentially required to be applied in educational institutions and in the teaching system of education today. Without character education, it means permitting the mix of clarity of understanding of moral values ​​and ambiguous nature which prevent students from making decisions based on a strong moral foundation. This study is a field research  which aims to determine the formation of character and factors that influence the formation of character of students at the Al-Fityah Integrated Islamic Primary School Pekanbaru. The type of research is qualitative research. The subject of this study was  teachers at the Alfityah Pekanbaru Integrated Islamic Primary School, amounting to 42 people. While the objects in this study were Al-Fityah Islamic Primary School Students totaling 439 people. Data collection techniques in research are observation, interviews, and documentation. Based on the results of this study, it showed that the Formation of students' Characters in the Al-Fityah Integrated Islamic Primary Schools Pekanbaru essentially teaches andimplements Islamic manners to students and then refuses them in their daily lives both in the school environment and in the home environment with reference to 10 muwasafat. Character formation is good in the school environment and it directly guided and cared for by the teachers, while at home the character formation of the children is guided by both parents through the Adab Monitoring Book (BMA) and then evaluated by the teacher at school. There are several factors that influence character formation, namely: family or parents, friends, environment, and the influence of television and other electronic media including the internet.
Peningkatan Kemampuan Membaca Huruf Hijaiyah Melalui Kartu Huruf Hijaiyah di PAUD
Authors: Alucyana Alucyana , Raihana Raihana , Utami Dian Tri
Published: May 2020

Early age is often referred to as the golden age (Golden Age) during which all aspects of development in children experience very significant development and this is the right time for parents and teachers to lay the foundations of the skills they will develop. To introduce letters hijaiyah to children after early childhood in some PAUD institutions are still applying conventional methods by using the book Iqro '. Introduction of hijaiyah letters can be varied by using hijaiyah letter cards. Learning model in the conventional way. This study wants to see the effectiveness of the use of hijaiyah letters in  improving the ability to read hijaiyah letters in early childhood in PAUD. The research method used in this study is Classroom Action Research (CAR). The results showed that the ability to read hijaiyah letters in B2 class PAUD Arrahma Siak Hulu increased by using hijaiyah letter media development. Evidenced by the results of cycle 1 that 50% complete reading hijaiyah letters while in increased to 93.75%
Analisis Pemasaran pada PT. Pegadaian (Persero) Cabang Syariah Ahmad Yani Pekanbaru
Authors: Zulkifli Zulkifli
Published: May 2020

Perkembangan pegadaian syariah di Pekanbaru semakin signifikan, bahkan kantor unit pelayanan syariah dari pegadaian syariah dengan mudah dapat dijumpai di berbagai sudut kota Pekanbaru. Hal ini tentulah ditunjang oleh strategi-strategi pemasaran yang jitu. Selain itu, pegadaian syariah juga sebaiknya tidak melupakan karakteristik pemasaran syariah. Penelitian ini bertujuan untuk mengetahui pelaksanaan strategi pemasaran yang dilakukan oleh PT Pegadaian (Persero) Cabang Syariah Ahmad Yani Pekanbaru dilihat dari konsep bauran pemasaran (marketing mix) dan untuk mengetahui tingkat penerapan karakteristik pemasaran syariah di PT Pegadaian (Persero) Cabang Syariah Ahmad Yani Pekanbaru. Subjek penelitian ini adalah nasabah dan karyawan PT Pegadaian (Persero) Cabang Syariah Ahmad Yani Pekanbaru. Populasi dalam penelitian ini adalah nasabah dan karyawan PT Pegadaian (Persero) Cabang Syariah Ahmad Yani Pekanbaru. Nasabah PT. Pegadaian (Persero) Cabang Syariah Ahmad Yani Pekanbaru berjumlah 2.310 orang, sedangkan karyawan PT Pegadaian (Persero) Cabang Syariah Ahmad Yani Pekanbaru berjumlah 9 orang. Sampel untuk populasi nasabah berjumlah 96 orang, diperoleh dengan menggunakan rumus slovin. Sedangkan sampel untuk populasi karyawan diambil dari seluruh karyawan yang berjumlah 9 orang. Teknik pengumpulan data menggunakan angket. Analisis data yang digunakan adalah dekriptif kuantitatif. Hasil penelitian ini adalah: a) Strategi pemasaran yang dilakukan oleh PT Pegadaian (Persero) Cabang Syariah Ahmad Yani Pekanbaru berjalan dengan sangat baik, karena nilai Persentase (P) berada pada interval 81% – 100%, yaitu 83%. b) Penerapan karakteristik pemasaran syariah pada PT Pegadaian (Persero) Cabang Syariah Ahmad Yani Pekanbaru berjalan dengan sangat baik, karena nilai Persentase (P) berada pada interval 81% – 100%, yaitu 98%.
Kemampuan Mengelola Interaksi Edukatif Guru Pendidikan Agama Islam
Authors: Hayati Najmi , Noer Muhammad Ali , Khoirol Waladun
Published: May 2020

Dalam melaksanakan interaksi edukatif dalam pembelajaran, seorang pendidik perlu memahami karakteristik peserta didik. Kegagalan menciptakan interaksi edukatif yang kondusif, berawal dari munculnya pemahaman pendidik terhadap karakteristik peserta didik. Rencana Pelaksanaan Pembelajaran (RPP) dalam proses pembelajaran tidak akan berlangsung sempurna bila minimnya pemahaman pendidik tentang karakteristik peserta didik. Dalam pemahaman interaksi ini akan muncul kreativitas guru dan peserta didik dalam proses belajar mengajar yang baik. Interaksi yang aktif dalam perannya akan membuat peserta didik memahami akan apa yang mereka pikirkan atas pelajaran dan pembelajaran yang telah diberikan guru Pendidikan Agama Islam pada mereka. Guru dapat melakukan usaha-usaha untuk mengembangkan dan menimbulkan motivasi belajar peserta didik dengan kemampuan mengolah interaksi yang baik dan berkualitas, dengan interaksi yang baik akan tercipta kelas yang harmonis dan intelektualitas.
A PENINGKATAN KEMAMPUAN BERPIKIR KRITIS MELALUI PENGGUNAAN STRATEGI ACTIVE SHARING KNOWLEDGE UPAYA MEMPERSIAPKAN GENERASI ABAD 21
Authors: FERAZONA SEPITA
Published: May 2020

This study aims to look at the Critical Thinking Ability Through the Use of Active Sharing Knowledge Strategies in an effort to prepare the 21st century generation of Material Excretion Systems. This research was conducted in April-July 2018/2019 Academic Year, at the Riau Islamic University, Faculty of Teacher Training and Education in Biology Study Program. The sample of this study consisted of one class, the determination of the sample by using purposive sampling technique. This type of research is a survey research with a qualitative approach. The method used in this research is experiment, which aims to find out a symptom or effect that arises, as a result of the existence of certain treatments. The data obtained were analyzed using quantitative data analysis techniques. The data obtained is the ability of students' critical thinking. The assessment of critical thinking abilities is carried out in accordance with the six indicators of critical thinking, namely: 1) Focus (focus), 2) Arguments (Reason), 3) Conclusions (inference), 4) Situation (Situation), 5) Clarity (Clarity), 6) Advanced Overview (Overview). The results showed that of the 17 critical thinking questions tested obtained a different presentation. 45% of the students' answers in the categories are very good and 55% are in the good categories. This proves that students' thinking on excretory material is good.
METODE SIMULASI BERBASIS PROJECT BASED LEARNING SEBAGAI ALTERNATIF UPAYA MENINGKATKAN MOTIVASI DAN HASIL BELAJAR KONSEP MUTASI PADA SISWA KELAS XII MIPA SMA NEGERI 1 MOGA TAHUN PELAJARAN 2019/2020
Authors: Masruri Masruri
Published: May 2020

Abstract

Research aims to determine the increased motivation of learning and learning outcomes of biological mutation concepts in the students of Grade XII MIPA SMA Negeri 1 Moga through the implementation of simulation methods based on project-learning, as well as the constraints experienced in the learning process. The instrument used consists of a poll to learn the student's motivation, and the multiple choice tests (pre-test and post-test) are selected to know the student's learning outcomes. The Data in this study was analyzed qualitatively and quantatatives. Qualitative analysis is conducted to determine the motivation for learning, while quantitative analysis is used to determine the improvement of student learning outcomes in the mutation concept. After the authors process the learning using a project Based learning simulation method in class XII MIPA3 SMAN 1 Moga Year lesson 2019/2020 there is an increase in learning motivation and student learning outcomes. Through this learning activity students can calculate.

 

Keywords: simulation methods, Project Based Learning, motivation, learning outcomes, mutation
PENGGUNAAN METODE MIND MAPPING UNTUK MENINGKATKAN HASIL BELAJAR PESERTA DIDIK PADA MATA PELAJARAN EKONOMI KELAS XII MIPA 1 SMA NEGERI 2 PEKANBARU
Authors: Angreta Angreta
Published: May 2020

This study aims to determine the increase of students learning outcomes through learning activities using Mind Mapping method in class XII MIPA 1 SMA Negeri 2 Pekanbaru. This research was conducted in July to September 2019. The subject was students of class XII MIPA 1 of SMA Negeri 2 Pekanbaru, totaling 36 students consist of 17 men and 19 women. This type of research is classroom action research. This research was conducted in two cycles for six meetings. Each meeting using the Mind Mapping method with consists of identifying the topic, planning the tasks to be studied, carrying out investigations, preparing final reports, presenting final reports, conclusions and evaluations. The research found that the usage of mind mapping method can improve the learning outcomes of class XII MIPA 1 SMA Negeri 2 Pekanbaru. The increasing was seen in the results of the first cycle with an average value of 84.13 and 92.66 in the second cycle. The percentage of students who pass the passing grade increase from 77.77% to 100%. Classroom action research with optimal usage of mind mapping method can improve learning outcomes in economic subject.
Fast Predictions of Liquid-Phase Acid-Catalyzed Reaction Rates Using Molecular Dynamics Simulations and Convolutional Neural Networks
Authors: Chew Alex , Jiang Shengli , Zhang Weiqi , Zavala Victor , Van Lehn Reid
Published: May 2020

The rates of liquid-phase, acid-catalyzed reactions relevant to the upgrading of biomass into high-value chemicals are highly sensitive to solvent composition and identifying suitable solvent mixtures is theoretically and experimentally challenging. We show that the atomistic configurations of reactant-solvent environments generated by classical molecular dynamics simulations can be exploited by 3D convolutional neural networks to enable fast predictions of Brønsted acid-catalyzed reaction rates for model biomass compounds. We develop a computational implementation, which we call SolventNet, and train it using experimental reaction data for seven biomass-derived oxygenates in water-cosolvent mixtures. We show that SolventNet can predict reaction rates for additional reactants and solvent systems an order of magnitude faster than prior simulation methods. This combination of machine learning with molecular dynamics enables the rapid screening of solvent systems and identification of improved biomass conversion conditions.
Combined Deep Learning and Molecular Docking Simulations Approach Identifies Potentially Effective FDA Approved Drugs for Repurposing Against SARS-CoV-2
Authors: Anwar Muhammad Umer , Adnan Farjad , Abro Asma , Khan Muhammad Rayyan , Rehman Asad Ur , Osama Muhammad , Javed Saad , Baig Ahmadullah , Shabbir Muhammad Raffey , Assir Muhammad Zaman
Published: May 2020

The ongoing pandemic of Coronavirus Disease 2019 (COVID-19), the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has posed a serious threat to global public health. Currently no approved drug or vaccine exists against SARS-CoV-2. Drug repurposing, represented as an effective drug discovery strategy from existing drugs, is a time efficient approach to find effective drugs against SARS-CoV-2 in this emergency situation. Both experimental and computational approaches are being employed in drug repurposing with computational approaches becoming increasingly popular and efficient. In this study, we present a robust experimental design combining deep learning with molecular docking experiments to identify most promising candidates from the list of FDA approved drugs that can be repurposed to treat COVID-19. We have employed a deep learning based Drug Target Interaction (DTI) model, called DeepDTA, with few improvements to predict drug-protein binding affinities, represented as KIBA scores, for 2,440 FDA approved and 8,168 investigational drugs against 24 SARS-CoV-2 viral proteins. FDA approved drugs with the highest KIBA scores were selected for molecular docking simulations. We ran docking simulations for 168 selected drugs against 285 total predicted and/or experimentally proven active sites of all 24 SARS-CoV-2 viral proteins. We used a recently published open source AutoDock based high throughput screening platform virtualflow to reduce the time required to run around 50,000 docking simulations. A list of 49 most promising FDA approved drugs with best consensus KIBA scores and AutoDock vina binding affinity values against selected SARS-CoV-2 viral proteins is generated. Most importantly, anidulafungin, velpatasvir, glecaprevir, rifabutin, procaine penicillin G, tadalafil, riboflavin 5’-monophosphate, flavin adenine dinucleotide, terlipressin, desmopressin, elbasvir, oxatomide, enasidenib, edoxaban and selinexor demonstrate highest predicted inhibitory potential against key SARS-CoV-2 viral proteins.
Drug Repurposing Studies Targeting SARS-nCoV2: An Ensemble Docking Approach on Drug Target 3C-like Protease (3CLpro)
Authors: Koulgi Shruti , Jani Vinod , Uppuladinne Mallikarjunachari , Sonavane Uddhavesh , Nath Asheet Kumar , Darbari Hemant , Joshi Rajendra
Published: May 2020

The COVID-19 pandemic has been responsible for several deaths worldwide. The causative agent behind this disease is the Severe Acute Respiratory Syndrome – novel Coronavirus 2 (SARS-nCoV2). SARS-nCoV2 belongs to the category of RNA viruses. The main protease, responsible for the cleavage of the viral polyprotein is considered as one of the hot targets for treating COVID-19. Earlier reports suggest the use of HIV anti-viral drugs for targeting the main protease of SARS-CoV, which caused SARS in the year 2002-03. Hence, drug repurposing approach may prove to be useful in targeting the main protease of SARS-nCoV2. The high-resolution crystal structure of 3CLpro (main protease) of SARS-nCoV2 (PDB ID: 6LU7) was used as the target. The Food and Drug Administration (FDA) approved and SWEETLEAD database of drug molecules were screened. The apo form of the main protease was simulated for a cumulative of 150 ns and 10 μs open source simulation data was used, to obtain conformations for ensemble docking. The representative structures for docking were selected using RMSD-based clustering and Markov State Modeling analysis. This ensemble docking approach for main protease helped in exploring the conformational variation in the drug binding site of the main protease leading to efficient binding of more relevant drug molecules. The drugs obtained as best hits from the ensemble docking possessed anti-bacterial and anti-viral properties. Small molecules with these properties may prove to be useful to treat symptoms exhibited in COVID-19. This in-silico ensemble docking approach would support identification of potential candidates for repurposing against COVID-19.
Molecular Detection of Epstein - Barr virus and Human Herpesvirus-6 in a Sample of Iraqi Patients with Acute Leukemia
Authors: Arwa Mujahid Al-Shuwaikh  , Dalya Basil Hanna  , Asmaa B. Al-Obaidi  , Ghaith Ali Jasim
Published: May 2020

The pathogenic roles of human herpesvirus-6 (HHV-6) and Epstein-Barr virus (EBV) in acute leukemia have been of great interest. Patients with leukemia should be evaluated for viral infection, so they could be diagnosed for optimal therapy. In the current study, we aimed to determine the frequency of HHV-6 and EBV in a sample of Iraqi patients with acute leukemia in children and adults before chemotherapy. Fluorescent probe-based quantitative polymerase chain reaction (Q-PCR) method was used to quantify copies of HHV-6 and EBV DNA in 20 cases of acute lymphoblastic leukemia (AML), and 40 cases of hematological stable control subjects. Also, the effects of viral infection on hematological parameters were investigated. Results show that (47.5%) 19 out of 40 of patients at diagnosis recorded positive to one of the investigated viruses. Thirteen (32.5%) and 12 (30%) out of 40 patients with acute leukemia had positive EBV and HHV-6 viremia, respectively, while none of control group shows positive result with highly significant differences between patients and control groups (P<0.001). The mean EBV and HHV-6 viral load was (7737.615±9106.838 copies/ml) and (94393.58±214528.9 copies/ml), respectively. In this study, there was no significant association between viral infection and hematological parameters (P>0.05).In conclusion, infections or co-infections with EBV and HHV-6 could be a factor in the development of acute leukemia but further studies are required to establish whether there is a real association.
REPRESENTATION OF SOME SPECIAL FUNCTIONS ON TRANSCENDENCE BASIS
Authors: Bui Chien Van
Published: May 2020

The special functions such as multiple harmonic sums, polyzetas or multiple polylogarithm functions are compatible with quasi-shuffle algebras. By using transcendence bases of the quasi-shuffle algebras studied in the paper [4], we will express non-commutative generating series of these special functions and then identify on the local coordinates to reduce their polynomial relations or asymptotic expansions indexed by these bases.
Pairing effects on neutron elastic scattering at low-energies
Authors: Hào Trần Viết Nhân , Nguyễn Hoàng Tùng , Trần Diệu Thùy , Đỗ Quang Tâm , Trần Ngọc Quỳnh Trân , Ha Anh Kim
Published: May 2020

For the first time, a realistic microscopic calculation for low-energy neutron-nucleus elastic scattering off open-shell nuclei is carried out within the framework of particle-vibration coupling (PVC). In this study, the pairing correlations of the ground state are taken into account. The dependence of the angular distributions on the pairing gaps have been discussed.
In vitro antioxidant activity and Content of compounds from Curculigo orchioides rhizome
Authors: Hiếu Lê Trung , Sơn Lê Lâm , Nguyệt Nguyễn Thị , Nhung Nguyễn Minh , Anh Vũ Hồ Xuân , Mẫn Nguyễn Quang , Trang Lê Thùy , Minh Trần Thanh , Thi Trần Thị Văn
Published: May 2020

Curculigo orchioides Gaertn. is used in traditional medicine in Vietnam. The antioxidant potential of Curculigo orchioides was evaluated through DPPH radical scavenging and total antioxidant capacity method. The data resulted from DPPH radical scavenging activities indicated that Curculigo orchioides displayed the good activities with low IC50 value (22.78μg/mL), approximately 1.5 times less than that of curcumin (34.34 μg/mL). The total antioxidant capacity of the extract of Curculigo orchioides contained 132.48 ± 1.48  mg GA/g or  264.45 ± 2.34 μmol AS/g. Content of compounds from Curculigo orchioides including the total phenolic, total flavonoid, polysaccharides, and saponin - triterpenoids were examined using the colorimetric method with reagents. The content of phenolic compounds, flavonoid compounds, polysaccharides, and saponin – triterpenoids found in Curculigo orchioides was  196.24 ± 1.45 mg GAE/g, 78.49 ± 1.78  mg QUE/g, 4.34 ± 0.08 %, 47.60 ± 0.24 mg Rb1/g (Rb1: (Gypenoside III)), respectively. Specifically, the total saponin - triterpenoid content of Curculigo orchioides has been reported for the first time.
Evaluation of Hematocrit Level, Red Blood Cells and White Blood Cells Counts in Blood from Patients with Different Severities of Periodontal Diseases
Authors: Ali Chinar J , Ahmed Maha A
Published: May 2020

Background: Anemia of chronic disease (ACD) occurs in the presence of chronic infection, inflammatory conditions or neoplastic conditions despite of adequate iron and vitamins storage. Gingivitis is the inflammation of the gingiva, periodontitis is the inflammation in the periodontium that extend deeper with loss of connective tissue attachment and supporting bone. The main pathogenesis of periodontal diseases and ACD is immune activation. Aims of study: Determine and compare the clinical periodontal parameters (plaque index (PLI), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD) and clinical attachment level (CAL)). Evaluate the hematocrit (Hct) level, red blood cells (RBCs) count and white blood cells (WBCs) count. Assess the correlations between the clinical periodontal parameters and hematological parameters at patients had gingivitis, chronic periodontitis (CP) with different severities (mild, moderate and severe) with healthy periodontium subjects. Materials and Methods: 35-50 years old, 150 male subjects were included in this study. They were divided into three study groups: group of 30 patients with gingivitis, group of 90 patients with CP which subdivided into (Mild CP=30 patients, Moderate CP =30 patients, Severe CP =30 patients) and control group 30 subjects with clinically healthy periodontium. Blood samples were collected then by automated blood analyzer the Hct, RBCs and WBCs were evaluated. Results: Comparisons among groups and subgroups revealed significant differences in Hct and WBCs, while RBCs was non-significant. Means values of RBCs count showed reduction in mild and severe CP subgroups. while, the Hct and WBCs mean values increased in patients with periodontal disease. The correlations between the clinical periodontal parameters with WBCs and RBCs were almost non-significant but, with Hct was mostly significant negative correlations. Conclusion: Inflammatory and immune responses in periodontal diseases caused change in different hematologic parameters which could contribute to the development of anemia of chronic disease.
Impact of Glycated Haemoglobin on salivary glucose among type 1 diabetic mellitus patients aged 18-22 years
Authors: Al- Khayoun Juman   D , Diab Ban    S
Published: May 2020

Background: Diabetes mellitus consists of a group of diseases characterized by abnormally high blood glucose levels. Glycated haemoglobin (HbA1c) is a form of haemoglobin used to identify the average concentration of plasma glucose over prolonged periods of time. It is formed in a non-enzymatic pathway by normal exposure of hemoglobin to high levels of plasma glucose, The main alterations observed in the saliva of Type 1 diabetic patients are hyposalivation and alteration in its composition, particularly those related to the levels of glucose. The aim of the present study was to assess the effect of Glycated haemoglobin level on the level of salivary glucose which may have an effect on oral health condition.
Materials and methods: The total sample composed of 50 adults aged 18-22 years. Divided into two groups: 25 uncontrolled diabetes mellitus (HbA1c > 7), 25 controlled diabetes mellitus (HbA1c ≤ 7). Stimulated salivary samples were collected under standardized condition according to the criteria of Tenovuo and Lagerlöf (1994). Salivary glucose was estimated by using spectrophotometric analysis. The data were analyzed by using SPSS version 18 (Statistical Package for Social Sciences) to specify the statistical differences between the two groups.
Results: the data of the present study assessed the correlation coefficients of HbA1c and salivary glucose and found that among uncontrolled diabetic group the relation between HbA1c and salivary glucose was significantly in positive direction (r = 0.483 p
The accuracy of ridge mapping procedure in determining the alveolar ridge width
Authors: Ahmed Athraa A , Bede Salwan Y
Published: May 2020

Background: Post-extraction alveolar ridge resorption is unavoidable phenomenon ending with insufficient ridge width. Measuring the physical dimensions of the available bone before implant surgery is an important aspect of diagnosis and treatment planning. Bone height can be calculated from radiographs, while bucco-lingual ridge width can be measured by conventional tomography, CT scanning and ridge mapping.

Radiographic techniques have certain disadvantages. Therefore the ridge mapping technique was used as an option for determining alveolar ridge width.

The purpose of this study was to compare the validity of alveolar ridge width measurements obtained with ridge mapping technique before surgical flap reflection against direct caliper measurement following surgical exposure of the bone.

Materials and Methods: This prospective observational clinical study included 21 patients; 9 males (42.9%) and 12 females (57.1%) with mean age of 40.8. A vacuum formed acrylic stent was fabricated for each subject. The stent provided two buccal/lingual pairs of consistent measurement points to provide a reference of measurement for each implant site located 3 and 6 mm from the crest of alveolar soft tissue. Measurements (n=216) were made at 54 implant sites, the measurements obtained from the two techniques were compared and then accuracy of these methods was assessed. The mean, standard deviation, standard error of mean were calculated and subjected to statistical analysis using Student’s unpaired t- test, values <0.05 were considered statistically significant.

Results: There was no statistically significant difference between ridge mapping technique and intra-operative measurement in determining alveolar ridge width.

Conclusion: The ridge mapping technique is a useful method in determining alveolar ridge width for its exactitude, low cost, the immediate result and no need of radiation.
Assessment of caries experience, enamel defects and selected salivary biomarkers in children with nutritional rickets
Authors: Jameel Sara A. , Al rawi Nadia A
Published: May 2020

Background: Nutritional Rickets is a condition produced by an absence of Vitamin D, calcium or phosphate. It clues to relaxing and fading of the bones. Dental expression of children with rickets contains enamel hypoplasia and delayed tooth eruption. This study was conducted in order to assess caries experience (dmfs) and enamel defects among study and control groups, and to evaluate and compare the levels of selected salivary biomarkers between children with nutritional rickets and apparently healthy children. Material and methods: Assessment of caries according to WHO in 1987, and assessment of enamel defects according to enamel defect index EDI of WHO in 1997. In addition a stimulated saliva samples were collected according to Palone et al from 30 children diagnosed with nutritional rickets and 30 control children as control group. Salivary vitamin D, calcium, phosphate and alkaline phosphtase were analyzed. Results: Caries experience represented by dmfs was significantly higher among control group compared to study group, while enamel hypoplasia was higher in study group than control group. Salivary inorganic component (Ca, PO4 ALP) revealed obvious variations between study and control group. Salivary vitamin D concentration was lower in study group compared with control group. Conclusion: Based on the results, it can be concluded that nutritional rickets impact on certain salivary biomarkers which can be considered for evaluating the diagnosis and prognosis of caries experience and enamel defects in nutritional rickets children
Impact of Brix 3000 and conventional restorative treatment on pain reaction during caries removal among group of children in Baghdad city
Authors: Ismail Mafaz M , Haidar Aseel   H
Published: May 2020

Background: Pain and the usage of local anesthetic agents are still real problem in pediatric dentistry, for these reasons, the use of minimal invasive dentistry (MID) in regard to the patient comfort is important especially for children, anxious and uncooperative patients. Chemomechanical caries removal (CMCR) methods involve the selective removal of the carious dentine hence it avoided the painful removal of the sound dentine and the anxiety resulted due to the vibration of the hand piece which is also decreased thus it appears to be more acceptable and comfortable to the patient. Aims of this study: This study was conducted among group of children to assess and compare the anxiety rating scale (during and after treatment) between the use of a recent chemomechanical caries removal method (by using Brix 3000) and the use of rotary instruments (using the ceramic bur). Materials and methods: Thirty pediatric patients aged between 8-12years, with bilateral occlusal carious permanent molars (extending into dentin) were selected for this study. Carious lesions were removed using Brix 3000 (CMCR) on one side and rotary instruments on the contra lateral side. Both cavities were restored with light cured composite filling. Anxiety scores were determined using Frankle rating scale (1962) during and after the period of caries removal. Results: The anxiety rating scale during the period of treatment showed the percentage of the negative behavior in the CMCR method was less than the percentage of the ceramic bur reverse the positive and definitely positive, which means that the new CMCR agent (Brix 3000) was more comfortable than the conventional rotary instrument (ceramic bur), that reduced the need for local anesthesia and the use of the drill. While after the treatment there is no big difference in the acceptance of the patients in two groups. Conclusion: Brix 3000 gel as a CMCR is an effective alternative method for caries removal, which appears to be more comfortable for the patients and more conservative
Taste Detection Thresholds in Relation to Salivary and Serum Zinc in Patients on Simvastatin Treatment
Authors: Mohammed Hassanien J. , Zaidan Taghreed  F.
Published: May 2020

Background: Hyperlipidemia is an elevated fat (lipids), mostly cholesterol and triglycerides, in the blood. These lipids usually bind to proteins to remain circulated so-called lipoprotein. Aims of the study: To determine taste detection threshold and estimate the trace elements (zinc) in serum and saliva of those patients and compare all of these with healthy control subjects. Methods: Eighty subjects were incorporated in this study, thy were divided into two groups: forty patients on simvastatin treatment age between (35-60) years, and forty healthy control of age range between (35-60) years. Saliva was collected by non-stimulated technique within 10 minutes. Serum was obtained from each subject. Zinc was estimated in serum and saliva by flame atomic absorption assay. Taste detection threshold was estimated by using 15 different concentrations of the four basic tastes solutions, the test use sip and spit with deionized water as mouth wash interval. Diabetics, thyroid and parathyroid disease, autoimmune disease, chemotherapy, smoking, alcoholics, neoplastic diseases were excluded. Results: The study showed that the taste detection threshold of sour and bitter were highly significantly higher in those patients than that in control subjects, sweet detection threshold were significantly high in patient on simvastatin. The salt detection threshold showed no significant differences between study groups. Salivary flow rate was significantly decreased in patients on simvastatin treatment than that in control subjects. Salivary and serum zinc were highly significantly decreased in control subjects than those in patients. There was highly significantly positive linear correlation between salivary flow rate and the mean of detection threshold of sweetness and sourness of both study groups, and highly significantly negative linear correlation with the mean of detection threshold of saltiness and bitterness in both study groups.
The accuracy of cone-beam computed tomography in the evaluation of boney support of teeth among patients with a unilateral cleft of lip and palate among IraqiPopulation
Authors: Kadhim Sahar   SH
Published: May 2020

Background: To evaluate the bony supports of the teeth adjacent to the area of cleft in patient with unilateral cleft lip and palate and to compare these measurements with the measurements of the same teeth in non-cleft side by using CBCT. Materials and methods: The CBCT scans of 30 patients having cleft lip( unilateral) and palate(unilateral), were analyzed and the measurements of the alveolar bony support for teeth that are adjacent to the cleft area were measured with those teeth located on opposite side (non- clef) side. For each tooth, the measurements will taken for the distance between the( cementoenamel junction) (CEJ) and the bony crest (AC) at the( buccal area) was measured and the thickness of the buccal plate At zero, one, two, and four mm. Results: The thickness of the bony support of central incisor at zero and one mm apically were statistically significantly thinner in cleft regions than in the non cleft regions. The CEJ-AC distance of the central teeth that are adjacent to the area of cleft was higher significantly than those for non-cleft area. For the canine teeth at 0, 1, 2, and 4mm apically were similar to those results obtained for central teeth at 0 and 1mm levels. Also, the CEJ-AC distance of the canine teeth that are adjacent to the cleft area was higher significantly than those for non-cleft area. Conclusion: person with unilateral cleft lip and palate showed a reduced alveolar bony support of the teeth located adjacent to the area of cleft when compared with the controls and This will cause a lot of problems in the future, so professional dental control is very essential for the maintaining of good periodontal health for those patients