bluuebunny/crossref_metadata_2025 huggingface dataset:
A game of hide and seek. Dramatic Mechanisms in Chekhov's «The Seagull»
Authors: Gorbachev Igor' Nikolaevich
Published: September 2023

The analysis of the play "The Seagull" undertaken in the article is based on an unusual assumption. Chekhov's phrase is known that "after writing a story, you should cross out its beginning and end." What if we apply this "formula" to the dramatic works of Anton Pavlovich and assume that when finishing the plays, Chekhov "left out some part of the text"? The analysis of the "Seagull" is performed directly by the classic tool of directors – the method of effective analysis. The work involved a wide range of facts about the social and everyday realities of the Russian Empire of the late XIX - early XX century. The choice of the play "The Seagull" is due to two reasons. Firstly, it is one of Chekhov's most famous and popular dramas. Interest in it has not waned for many decades, neither the audience nor the directors. Secondly, it is believed that the "Seagull" is read inside and out, and working with it is a challenge for the researcher. The analysis of "The Seagull" allows us to state that Chekhov's formula about "crossing out the beginning and the end" of the story is also applicable to his plays. Moreover, this "crossing out" is made taking into account the principles of classical drama. As a result, the reader is faced with the fact that the "Seagull" can be read in at least two – almost opposite in meaning – ways. The results obtained during the analysis, firstly, give grounds to assume that the case of the "Seagull" is not an isolated one, and Chekhov resorted to similar techniques in his other dramas. Secondly, to conclude that the "dramatic mechanism" of The Seagull is not just an attribute of the author's voice, but actually the path of evolution of classical drama proposed by Chekhov.
A multipolar world and a dispute about value priorities. Review of the XXI International Likhachev Scientific Readings
Authors: Nikonova Svetlana
Published: September 2023

In this article, readers are presented with an analysis of some of the problems that became the center of discussion at the XXI International Likhachev Scientific Readings held in May 2023 at the St. Petersburg Humanitarian University of Trade Unions. The readings were held under the general title "Dialogues and conflicts of cultures in a changing world", combining the traditional theme of dialogue with the problems of conflict that have arisen in recent years. This review focuses on two significant issues, one of which determined the course of the plenary discussion, and the other became the main one for the breakout session devoted to the values and trends of the modern world. The main issue of the plenary session was the consideration of the conflict between the unipolar and multipolar world. Both domestic and foreign participants actively spoke out on this issue. The speakers who spoke at the Readings adhered to the idea of prioritizing the values of a multipolar world, pointing to the undemocratic nature of unipolarity. Analyzing this aspect of the discussion, the author of the review notes that in modern society the same value attitudes develop to the limits where they lead to opposite conclusions. The idea of unipolarity implies the uniqueness of the democratic model. From the idea of multipolarity, there are many different development scenarios, which looks like a more democratic position. It can be concluded that the value attitude coincides, but the basis of the ideological conflict is a political conflict. Nevertheless, the final value discrepancy is very acute. The philosophical and cultural section of the conference was devoted to this. Noting the sharpness of the criticism expressed by the speakers to the "new ethics" and the "culture of cancellation", the author of the review points out that in this criticism there is a desire to "cancel" the criticized, which again unites both positions, but does not provide grounds for a constructive dialogue. To overcome the contradiction, a rational analysis of the ideological and historical foundations, as well as the dynamics of the development of opposing value positions, is necessary.
Formation of vocal and pedagogical traditions of the Saratov Conservatory in the context of the pedagogical views of M. E. Medvedev and A.M. Paskhalova
Authors: Rudyakova Alla Eduardovna
Published: September 2023

The article, based on archival data, as well as preserved testimonies of students, attempts to reconstruct the pedagogical views of M. E. Medvedev and A.M. Paskhalova, whose teaching activity was the basis for the subsequent formation of the vocal and pedagogical traditions of the Saratov Conservatory. The object of research here is the vocal and pedagogical traditions of the Saratov Conservatory, the subject is the pedagogical views of the professors of the initial period of activity of the educational institution under consideration - M. E. Medvedev and A.M. Paskhalova. The paper analyzes the book of the student M. E. Medvedev baritone S. Y. Levik "Notes of an opera singer", as well as the methodological work of A.M. Paskhalova "Work on the production of voice for the leaders of the Russian folk song choir". It is revealed that, despite the differences in some aspects of the vocalist's voice production (soundless exercises, scientific foundations of vocalist education, the use of vocalizations, etc.), the activities of M. E. Medvedev and A. M. Paskhalova is characterized by the following general provisions: a rather low type of breathing, increased attention to the development of a sense of sound support, a cautious attitude to the development of a full range of voice, the development of clear diction, evenness of sound studies, smoothness of register transitions; soft sound attack; the ability to vocalize various dynamic gradations of vocalization qualitatively; the use of a "concentric" teaching method in the pedagogical process, increased attention to the upbringing of the emotional and dramatic component of the performer's personality. The analysis also showed that the features distinguishing the pedagogical views of professors of the initial period of the Saratov Conservatory's activity can be attributed to the use of the repertoire of Russian composers in classroom work at the initial stage of training singers.
Parental Involvement in their Children’s Education as a Function of Family Size: The Case of Israel
Authors: Mashiach Amir , Davidovich Nitza
Published: September 2023

The modern era allows a reexamination of parental involvement in their children’s education as a function of family size. Israel encourages childbirth. ‘Children are joy’ ‐ Indeed? Is this merely a sectorial-religious outlook? Is this outlook relevant in an
era when the dominant values are the individual and excellence? This article presents a case study of whether parents in multi-child families in Israel, with four or more children, are less involved in their children’s studies than parents in small families. Not every parent can be truly
invested in his or her children’s life due to a lack of time, lack of pedagogic skill, fatigue, work pressures, and more. The more children in the family, the more children-consumers share the parents’ attention. This means that each child receives a smaller ‘slice’
of the ‘pie’ of capabilities and resources, and vice versa, in families with few children each child receives a larger ‘slice of the pie’. Is this indeed true? The research findings showed a significant correlation between parental involvement and the size of the family
unit, namely, the more children there are the less the parental involvement. The research findings illuminate a topic that occupies researchers from different disciplines, as it has economic, social, and ethical, educational, and global implications.
Challenges and Issues in Spatial Data Infrastructure (SDI) Development in Iraq
Authors: Al-Bakri Maythm , Fairbairn David
Published: September 2023

This paper addresses the nature of Spatial Data Infrastructure (SDI), considered as one of the most important concepts to ensure effective functioning in a modern society. It comprises a set of continually developing methods and procedures providing the geospatial base supporting a country’s governmental, environmental, economic, and social activities. In general, the SDI framework consists of the integration of various elements including standards, policies, networks, data, and end users and application areas. The transformation of previously paper-based map data into a digital format, the emergence of GIS, and the Internet and a host of online applications (e.g., environmental impact analysis, navigation, applications of VGI data, governmental efficiency drives) have led to huge leaps forward in SDI development. However, SDI progress can be held back by numerous challenges, both technical and non-technical. The paper outlines these challenges from the perspective of the country of Iraq, where there is an absence of a clear direction towards efficient SDI operation and a lack of knowledge for establishing and managing effective SDI. These challenges could be met by considering and resolving generic issues, identified by the experiences of other nations, by researchers, and by organisations. These issues are investigated and assessed by means of a questionnaire survey and interviews, directed towards important participants in the field of SDI development in the country. The results present the SDI issues in order of relevance to assist developers and users in solving potential SDI and data integration problems within Iraq.
Systematic Analysis of Network-driven Adaptive Resistance to CDK4/6 and Estrogen Receptor Inhibition using Meta-Dynamic Network Modelling
Authors: Hart Anthony , Shin Sung-Young , Nguyen Lan K.
Published: September 2023

Drug resistance inevitably emerges during the treatment of cancer by targeted therapy. Adaptive resistance is a major form of drug resistance, wherein the rewiring of protein signalling networks in response to drug perturbation allows the drug-targeted protein’s activity to recover, despite the continuous presence of the drug, enabling the cells to survive/grow. Simultaneously, molecular heterogeneity enables the selection of drug-resistant cancer clones that can survive an initial drug insult, proliferate, and eventually cause disease relapse. Despite their importance, the link between heterogeneity and adaptive resistance, specifically how heterogeneity influences protein signalling dynamics to drive adaptive resistance, remains poorly understood. Here, we have explored the relationship between heterogeneity, protein signalling dynamics and adaptive resistance through the development of a novel modelling technique coined Meta Dynamic Network (MDN) modelling. We use MDN modelling to characterise how heterogeneity influences the drug-response signalling dynamics of the proteins that regulate early cell cycle progression and demonstrate that heterogeneity can robustly facilitate adaptive resistance associated dynamics for key cell cycle regulators. We determined the influence of heterogeneity at the level of both protein interactions and protein expression and show that protein interactions are a much stronger driver of adaptive resistance. Owing to the mechanistic nature of the underpinning ODE framework, we then identified a full spectrum of subnetworks that drive adaptive resistance dynamics in the key early cell cycle regulators. Finally, we show that single-cell dynamic data supports the validity of our MDN modelling technique and a comparison between our predicted resistance mechanisms and known CDK4/6 and Estrogen Receptor inhibitor resistance mechanisms suggests MDN can be deployed to robustly predict network-level resistance mechanisms for novel drugs and additional protein signalling networks.
Polymorphisms in Intron 1 of HLA-DRA Differentially Associate with Type 1 Diabetes and Celiac Disease and Implicate Involvement of Complement System Genes C4A and C4B
Authors: Aydemir Özkan , Bailey Jeffrey A. , Agardh Daniel , Lernmark Åke , Noble Janelle A. , Svärd Agnes Andersson , Blankenhorn Elizabeth P. , Parikh Hemang , Ziegler Anette-G. , Toppari Jorma , Akolkar Beena , Hagopian William A. , Rewers Marian J. , Mordes John P. ,   TEDDY Study Group
Published: September 2023

Polymorphisms in genes in the human leukocyte antigen (HLA) class II region comprise the most important inherited risk factors for many autoimmune diseases including type 1 diabetes (T1D) and celiac disease (CD): both diseases are positively associated with the HLA-DR3 haplotype (
DRB1*03:01-DQA1*05:01-DQB1*02:01
). Studies of two different populations have recently documented that T1D susceptibility in HLA-DR3 homozygous individuals is stratified by a haplotype consisting of three single nucleotide polymorphisms (“tri-SNP”) in intron 1 of the
HLA-DRA
gene. In this study, we use a large cohort from the longitudinal “The Environmental Determinants of Diabetes in the Young” (TEDDY) study to further refine the tri-SNP association with T1D and with autoantibody-defined T1D endotypes. We found that the tri-SNP association is primarily in subjects whose first-appearing T1D autoantibody is to insulin. In addition, we discovered that the tri-SNP is also associated with celiac disease (CD), and that the particular tri-SNP haplotype (“101”) that is negatively associated with T1D risk is positively associated with risk for CD. The opposite effect of the tri-SNP haplotype on two DR3-associated diseases can enhance and refine current models of disease prediction based on genetic risk. Finally, we investigated possible functional differences between the individuals carrying high and low-risk tri-SNP haplotypes, and found that differences in complement system genes C4A and C4B may underlie the observed divergence in disease risk.
Positive selection and relaxed purifying selection contribute to rapid evolution of male-biased genes in a dioecious flowering plant
Authors: Zhao Lei , Zhou Wei , He Jun , Li De-Zhu , Li Hong-Tao
Published: September 2023

Sex-biased genes offer insights into the evolution of sexual dimorphism. Sex-biased genes, especially those with male bias, show elevated evolutionary rates of protein sequences driving by positive selection and relaxed purifying selection in animals. Although rapid sequence evolution of sex-biased genes and evolutionary forces have been investigated in animals and brown algas, less is known about them in dioecious angiosperms. In this study, we separately compared the expression of sex-biased gene between female and male flower buds and between female and male mature flowers in dioecious
Trichosanthes pilosa
(Cucurbitaceae). In floral buds, sex-biased gene expression was pervasive, and had significantly different roles on sexual dimorphism such as physiology. We observed higher rates of sequence evolution for male-biased genes in floral buds compared to female-biased and unbiased genes. Male-biased genes under positive selection were mainly related to abiotic and biotic stress, suggesting that high evolutionary rates are driven by adaptive evolution. Additionally, relaxed purifying selection may contribute to accelerated evolution in male-biased genes generated by gene duplication. Our findings, for the first time in dioecious angiosperms, suggest evident rapid evolution of male-biased genes, advance our understanding of the patterns and forces driving the evolution of sexual dimorphism in dioecious plants.
Mitochondrial genomes of Pleistocene megafauna retrieved from recent sediment layers of two Siberian lakes
Authors: Seeber Peter Andreas , Batke Laura , Dvornikov Yury , Schmidt Alexandra , Wang Yi , Stoof-Leichsenring Kathleen , Moon Katie , Vohr Samuel H , Shapiro Beth , Epp Laura S
Published: September 2023

Ancient environmental DNA (aeDNA) from lake sediments has yielded remarkable insights for the reconstruction of past ecosystems, including suggestions of late survival of extinct species. However, translocation and lateral inflow of DNA in sediments can potentially distort the stratigraphic signal of the DNA. Using three different approaches on two short lake sediment cores of the Yamal peninsula, West Siberia, with ages spanning only the past hundreds of years, we detect DNA and identified mitochondrial genomes of multiple mammoth and woolly rhinoceros individuals—both species that have been extinct for thousands of years on the mainland. The occurrence of clearly identifiable aeDNA of extinct Pleistocene megafauna (e.g. >400 K reads in one core) throughout these two short subsurface cores, along with specificities of sedimentology and dating, confirm that processes acting on regional scales, such as extensive permafrost thawing, can influence the aeDNA record and should be accounted for in aeDNA paleoecology.
Avoiding false discoveries in single-cell RNA-seq by revisiting the first Alzheimer’s disease dataset
Authors: Murphy Alan E , Fancy Nurun , Skene Nathan
Published: September 2023

Mathys et al. conducted the first single-nucleus RNA-seq (snRNA-seq) study of Alzheimer’s disease (AD) (Mathys et al., 2019). With bulk RNA-seq, changes in gene expression across cell types can be lost, potentially masking the differentially expressed genes (DEGs) across different cell types. Through the use of single-cell techniques, the authors benefitted from increased resolution with the potential to uncover cell type-specific DEGs in AD for the first time. However, there were limitations in both their data processing and quality control and their differential expression analysis. Here, we correct these issues and use best-practice approaches to snRNA-seq differential expression, resulting in 549 times fewer DEGs at a false discovery rate of 0.05. Thus, this study highlights the impact of quality control and differential analysis methods on the discovery of disease-associated genes and aims to refocus the AD research field away from spuriously identified genes.
Precise Spatial Tuning of Visually Driven Alpha Oscillations in Human Visual Cortex
Authors: Yuasa Kenichi , Groen Iris I.A. , Piantoni Giovanni , Montenegro Stephanie , Flinker Adeen , Devore Sasha , Devinsky Orrin , Doyle Werner , Dugan Patricia , Friedman Daniel , Ramsey Nick , Petridou Natalia , Winawer Jonathan
Published: September 2023

Neuronal oscillations at about 10 Hz, called alpha oscillations, are often thought to arise from synchronous activity across occipital cortex, reflecting general cognitive states such as arousal and alertness. However, there is also evidence that modulation of alpha oscillations in visual cortex can be spatially specific. Here, we used intracranial electrodes in human patients to measure alpha oscillations in response to visual stimuli whose location varied systematically across the visual field. We separated the alpha oscillatory power from broadband power changes. The variation in alpha oscillatory power with stimulus position was then fit by a population receptive field (pRF) model. We find that the alpha pRFs have similar center locations to pRFs estimated from broadband power (70–180 Hz), but are several times larger. The results demonstrate that alpha suppression in human visual cortex can be precisely tuned. Finally, we show how the pattern of alpha responses can explain several features of exogenous visual attention.The alpha oscillation is the largest electrical signal generated by the human brain. An important question in systems neuroscience is the degree to which this oscillation reflects system-wide states and behaviors such as arousal, alertness, and attention, versus much more specific functions in the routing and processing of information. We examined alpha oscillations at high spatial precision in human patients with intracranial electrodes implanted over visual cortex. We discovered a surprisingly high spatial specificity of visually driven alpha oscillations, which we quantified with receptive field models. We further use our discoveries about properties of the alpha response to show a link between these oscillations and the spread of visual attention.
Deciphering the chemical language of inbred and wild mouse conspecific scents
Authors: Nagel Maximilian , Niestroj Marco , Bansal Rohini , Fleck David , Lampert Angelika , Stopkova Romana , Stopka Pavel , Ben-Shaul Yoram , Spehr Marc
Published: September 2023

In most mammals, conspecific chemosensory communication relies on semiochemical release within complex bodily secretions and subsequent stimulus detection by the vomeronasal organ (VNO). Urine, a rich source of ethologically relevant chemosignals, conveys detailed information about sex, social hierarchy, health, and reproductive state, which becomes accessible to a conspecific via vomeronasal sampling. So far, however, numerous aspects of social chemosignaling along the vomeronasal pathway remain unclear. Moreover, since virtually all research on vomeronasal physiology is based on secretions derived from inbred laboratory mice, it remains uncertain whether such stimuli provide a true representation of potentially more relevant cues found in the wild. Here, we combine a robust low-noise VNO activity assay with comparative molecular profiling of sex- and strain-specific mouse urine samples from two inbred laboratory strains as well as from wild mice. With comprehensive molecular portraits of these secretions, VNO activity analysis now enables us to (i) assess whether and, if so, how much sex/strain-selective ‘raw’ chemical information in urine is accessible via vomeronasal sampling; (ii) identify which chemicals exhibit sufficient discriminatory power to signal an animal’s sex, strain, or both; (iii) determine the extent to which wild mouse secretions are unique; and (iv) analyze whether vomeronasal response profiles differ between strains. We report both sex- and, in particular, strain-selective VNO representations of chemical information. Within the urinary ‘secretome’, both volatile compounds and proteins exhibit sufficient discriminative power to provide sex- and strain-specific molecular fingerprints. While total protein amount is substantially enriched in male urine, females secrete a larger variety at overall comparatively low concentrations. Surprisingly, the molecular spectrum of wild mouse urine does not dramatically exceed that of inbred strains. Finally, vomeronasal response profiles differ between C57BL/6 and BALB/c animals, with particularly disparate representations of female semiochemicals.
Dynamic allosteric networks drive adenosine A1 receptor activation and G-protein coupling
Authors: Maria-Solano Miguel A , Choi Sun
Published: September 2023

G-protein coupled receptors (GPCRs) present specific activation pathways and signaling among receptor subtypes. Hence, an extensive knowledge of the structural dynamics of the receptor is critical for the development of therapeutics. Here, we target the adenosine A1 receptor (A1R), for which a negligible number of drugs have been approved. We combine molecular dynamics simulations, enhanced sampling techniques, network theory, and pocket detection to decipher the activation pathway of A1R, decode the allosteric networks, and identify transient pockets. The A1R activation pathway reveals hidden intermediate and pre-active states together with the inactive and fully-active states observed experimentally. The protein energy networks computed throughout these conformational states successfully unravel the extra and intracellular allosteric centers and the communication pathways that couple them. We observe that the allosteric networks are dynamic, being increased along activation and fine-tuned in the presence of the trimeric G-proteins. Overlap of transient pockets and energy networks uncovers how the allosteric coupling between pockets and distinct functional regions of the receptor is altered along activation. Through an in-depth analysis of the bridge between the activation pathway, energy networks, and transient pockets, we provide a further understanding of A1R. This information can be useful to ease the design of allosteric modulators for A1R.
The BTB-ZF gene Bm-mamo regulate pigmentation in caterpillars
Authors: Wu Songyuan , Tong Xiaoling , Peng Chenxing , Lu Kunpeng , Luo Jiangwen , Li Chunlin , Zhang Chenghao , Ding Xin , Lu Yaru , Duan Xiaohui , Hu Hai , Tan Duan , Dai Fangyin
Published: September 2023

Color pattern of insects is one of the most dazzling adaptive evolutionary phenotypes. However, the molecular regulation of this color pattern is not clear. In this paper, we found a transcription factor,
Bm-mamo
, is responsible for
bd
(
black dilute
) allele mutants in silkworm. It belongs to BTB zinc finger family, and is ortholog to
mamo
of
Drosophila melanogaster
, which It is found that this gene has conservative function in gamete production, and evolved a pleiotropic function in regulation of color patterns in caterpillar. We found that the
Bm-mamo
can comprehensively regulate the expression of related pigment synthesis and cuticular protein genes to form color patterns. This suggests that the deposition of pigment particles in caterpillars’ epidermis requires not only the spatiotemporal expression of pigment synthesis genes, but also the correct expression of related cuticular protein genes. This study provides a new data for the setting of color patterns.
Assessment of selection criteria using multi-year study for effective breeding program of Zingiber officinale L
Authors: Begum Twahira , Gogoi Roktim , Gogoi Ankita , Gupta Tanmita , Chanda Sanjoy Kumar , Lekhak Himangshu , Lal Mohan
Published: September 2023

Background

Ginger has been an important cash crop with numerous applications since ancient times. As the demand for ginger is ever-growing and being a seasonal crop, a high-yielding variety of ginger would be economically profitable.

Methods

In this study, 150 germplasm were collected from different regions of NE India and evaluated for three years in CRBD design with three replications. The present study thus focused on the variability, association, and diversity studies for the first time on 150 ginger germplasm from across North East India. The genotypic and phenotypic coefficient of variation, heritability, correlation, and path analysis were evaluated for the germplasm.

Results

Analysis of variance (ANOVA) revealed considerable differences among the studied germplasm for studied characters, revealing sufficient variability in the materials. The Mahalanobis D2 and Tocher methods grouped the 150 ginger germplasm into ten clusters. Based on the results of the path coefficient analysis determined for essential oil yield and rhizome yield per plant, it can be concluded that the characters’ initial rhizome weight, the weight of mother rhizome, and weight of secondary rhizome were the most important and appeared promising in improving the overall yield potential of ginger rhizome and essential oil yield. Thus, selection based on the identified traits would lead to an effective ginger breeding program for higher rhizome and essential oil yield.
The Influence of Attitude toward Job Rotation, Professional Self-concept and Organizational Commitment on Patient Safety Nursing Activities: A Cross-Sectional Study
Authors: Park Minji , Park Hyojung
Published: September 2023

Purpose: This study aimed to examine the influence of attitude toward job rotation, professional self-concept and organizational commitment on patient safety nursing activities.Methods: In this descriptive correlational study, the participants were 120 nurses with over 1 year of experience working at a tertiary general hospital in Seoul. Data were analyzed using descriptive statistics, the independent t-test and one-way analysis of variance, the Scheffé test, Pearson correlation coefficients, and hierarchical multiple regression analysis.Results: The average scores for attitude toward job rotation, professional self-concept, organizational commitment and patient safety nursing activities were 3.07±0.43, 5.80±0.87, 3.11±0.55, and 4.57±0.35, respectively. Patient safety nursing activities showed statistically significant differences according to age (F=4.66, p=.011), marital status (t=-2.06, p=.042), and total clinical experience (t=-2.38, p=.019). Attitude toward job rotation (r=.23, p=.011), professional self-concept (r=.36, p<.001), and organizational commitment (r=.30, p<.001) were positively correlated with patient safety nursing activities. The Factors affecting patient safety nursing activities were total clinical experience (β=.24, p=.029) and professional self-concept (β=.22, p=.037), with a total explanatory power of approximately 20%.Conclusion: These results suggest that nurses’ activities need to be planned based on their total clinical experience. and professional self-concept predicted higher patient safety nursing activities among nurses.
Development and Evaluation of Passion Continuation Program based on GRIT Theory for Nurses in COVID-19 Pandemic: A Non-Randomized Experimental Study
Authors: Lee Do-Young , Je Nam-Joo , Kim Yoon Jung , Jang Chunseon , Kim Hyun-Ju
Published: September 2023

Purpose: This study aimed to examine the effects of a GRIT theory-based program on GRIT, emotional labor, and job crafting among nurses at nursing hospitals.Methods: The program was developed based on GRIT theory and designed for nurses at nursing hospitals during the COVID-19 pandemic. To test the effects of the program on GRIT, emotional labor, and job crafting, the study was conducted as a quasi-experimental design with a non-equivalent control group. From April 25 to May 22, 2022, a total of 40 nurses in nursing hospitals participated in the program for 25 minutes per session, twice a week for 4 weeks. The collected data were analyzed using SPSS 24.0.Results: The program increased GRIT (F=8.55, p=.006) and job crafting (F=13.48, p=.002) among nurses at nursing hospitals, but had no significant effect on the level of emotional labor (F=0.64, p=.427).Conclusion: The GRIT theory-based program analyzed in this study was effective in enhancing GRIT and job crafting of nurses at nursing hospitals and is expected to have a positive influence on nurses' active and passionate working environment.
Um estudo sobre as estratégias metacognitivas de aprendizado autorregulado dos discentes do curso de ciências contábeis de uma instituição de ensino superior pública do Espírito Santo (ES)
Authors: De Brito Uilian , Arrigoni Fernando José , Pires Mirian Albert , Maria Michele Monteiro Lirio , Diniz Ana Carolina Ferreira
Published: September 2023

Buscando contribuir para debates sobre mudanças metodológicas, estudou o comportamento autorregulado dos discentes do curso de Contabilidade. As estratégias metacognitivas de aprendizado autorregulado são processos de amplificação de aprendizado que estão subdivididas em 14 e que segundo a literatura quanto mais os discentes se utilizam dessas estratégias mais ativos serão. Assim, objetivou-se em identificar as estratégias metacognitivas que os discentes do curso de Ciências Contábeis de uma Instituição de Ensino Superior Pública do Espírito Santo adotam com maior frequência e se a adoção de tais estratégias aumenta no decorrer do curso. Foram pesquisados discentes do curso de Contabilidade, turnos vespertino e noturno da IES, a referida IES foi selecionada dado o alto índice de reprovação que causa desperiodização, abandono do curso. Por meio da abordagem quantitativa, foi possível apurar, tabular e apresentar dados do fenômeno, com uma amostra de 208 discentes. Ademais, os instrumentos estatísticos utilizados na metodologia permitiram a identificação do grau de comportamento ativo dos discentes nas duas etapas do curso. Comparando as respostas dos alunos da 1º ao 4º período com as dos discentes do 5º ao 8º período, constatou-se que eles não adotam, de forma crescente, nas duas principais partes do curso as estratégias metacognitivas. Ou seja, não existe diferença significativa no uso das estratégias da primeira parte (1º ao 4º período) em relação a segunda parte curso (5º ao 8º período). A presente pesquisa concluiu que os discentes do curso de Ciência Contábeis da IES não aumentam o uso das estratégias metacognitivas durante o curso, fato que explica o alto índice de reprovação dos discentes. O presente trabalho contribuiu ao identificar que o comportamento ativo dos discentes do curso de Contabilidade da IES do ES não tem aumentado no decorrer do curso e isso torna necessário debates acerca de mudanças metodológicas no processo de ensino/aprendizagem.
Hemisection for the Successful Preservation of Hopeless Teeth: A Case Report
Authors: Tilokani Akansha , Ganguli Bidushi , Pradhan Prasanti Kumari , Jalaluddin Mohammad
Published: September 2023

Hemisection is conservative way of preserving tooth , which is defined as the surgical procedure that involves removal of a weakened root and compromised crown portion which may be affected by periodontal, endodontic, or structural failures. It aims to efficacious atternative modality in the extraced to save multirooted teeth. This treatment option should be considered when caries, resorption, perforation, or periodontal damage is confined to one root, whereas the other root is healthier. As long as, Expected results can be achieved with this treatment by following the proper diagnostic, endodontic, surgical, prosthetic, and maintenance procedures are followed, this treatment can produce. Present study describes the successful treatment two patients with severely damaged mandibular molars through hemisection. The procedure was successfully and the remaining portion of the tooth was restored with a prosthesis. The patients were followed up for several months, and the outcome was satisfactory, with no recurrence of symptoms. Hemisection can be an effective treatment option for preserving a damaged tooth, and this case report demonstrates its successful application in a clinical setting.
Maternal and Perinatal Outcomes in Planned Labour: A Prospective Interventional Study
Authors: Gupta Khyati , Maravi Dolly , Tiwari Priyadarshini , Khan Azra , Singh Raksha , Rajpoot Bhoomija
Published: September 2023

Introduction: Labour, especially in primiparas, is associated with intense pain. Patients labouring without analgesia may experience longer durations in all stages, along with the suffering associated with labour pains. The study was conducted to determine whether a programmed labour regime provided adequate pain relief and accelerated the labour process. Aim: To compare the maternal and perinatal outcomes in patients who underwent conventional labour with those who received programmed labour analgesia. Materials and Methods: This prospective interventional study was conducted in the Department of Obstetrics and Gynecology at Netaji Subhash Chandra Bose Medical College and Hospital in Jabalpur, Madhya Pradesh, India. The study duration was one year and five months, from March 2021 to August 2022. A total of 100 patients, including 50 low-risk primiparas in each group with cervical dilatation of 3 to 4 cm, were randomly allocated to the case and control groups. The case group received a programmed labour regime, which involved administering small doses of various drugs such as pentazocine, drotaverine, diazepam, and tramadol. No analgesia was given to the control group. Pain relief assessment was conducted using a Visual Analogue Scale (VAS). The duration of the various stages of labour and the rate of cervical dilatation were assessed in both groups. Data analysis was performed using Statistical Package for Social Sciences (SPSS) version 23.0. Results: The mean age of the study subjects in the control group was 24.14±2.39 years, and in the case group, it was 24.26±2.49 years. Compared to the control group, 29 (58%) cases experienced mild pain, and 21 (42%) experienced moderate pain. The rate of cervical dilatation was 2.57±1.41 cm/hour in the case group compared to 1.41±0.36 cm/hour in the control group (p-value <0.001). The mean duration of the first (cervical dilatation from 3-4 cm onwards), second, and third stages of labour was 140.2±35.06 minutes, 25.22±9.41 minutes, and 3.56±0.91 minutes, respectively, in the case group. The duration of all stages of labour was significantly reduced in the case group (p-value <0.001). Minimal side effects were observed, with nausea being the most common side effect in 16% of cases. Conclusion: Programmed labour resulted in shorter and more comfortable labour with minimal adverse effects. This method does not require a trained anaesthetist; thus, it can be easily administered in low-resource settings.
Implementation of Personnel Management Information Systems in Agency of Personnel and Human Resource Development Regional Tojo Una–Una District of Central Sulawesi
Authors: Andrianto  , Rifdan  , Samad Sulaiman
Published: September 2023

This study aims to describe the mechanism for implementing management information systems, supporting factors, inhibiting factors, and determining the strategy for implementing personnel management information systems at the Regional Personnel and Human Resources Development Agency in Tojo Una-Una Regency. The type of research used is descriptive qualitative research. Data collection techniques used were interviews and documentation with validation and data analysis using SWOT analysis and interactive models (collection, reduction, presentation, and Drawing conclusions) from Miles and Huberman. Factors supporting the implementation of management information systems from internal factors, namely employee loyalty in carrying out tasks with full responsibility and support from leaders who support the implementation of personnel management information systems properly. In addition, from external factors is the Implementation of the Merit System in the management of State Civil Apparatus which is mandated in the ASN Law No. 5 of 2014. The inhibiting factors for the implementation of the personnel management information system from internal factors are the uneven quality and quantity of existing human resources, as well as the lack of supporting facilities. Such as computers, document scan tools and unstable internet network infrastructure. From internal factors, there is a mutation of employees, which is carried out using a (spoil) approach and limited budgetary funding support. The implementation strategy is to carry out education and training activities for human resources, improve facilities and infrastructure, and further enhance the integration of data and information communication between sectors.
Unleashing the Power of Cloud Computing for Big Data Management: Advantages, Challenges, and Future Prospects
Authors: Aslam Farhan
Published: September 2023

In the era of digitization, big data analytics has become essential for various sectors. Traditional computing systems often struggle to handle the demands of big data. This article explores cloud computing as a viable solution, emphasizing its scalability and flexibility. Through a comprehensive literature review, two case studies were analyzed, showcasing the advantages of cloud computing in big data processing. The findings reveal that cloud platforms not only enhance computational efficiency but also offer practical benefits for businesses, aiding in informed decision-making. As big data continues to grow, cloud computing stands out as a pivotal tool in addressing its challenges and harnessing its potential.
Effect of Indole Butyric Acid and Zinc Sulphate in Different Media on Rooting of Olive Cuttings
Authors: Afzal Muhammad , Naeem Hafsa , Waqas Muhammad , Akhtar Isbah , Razaullah  , Imranullah  , Alam Sabeen , Tehseen Monaza , Sanaullah
Published: September 2023

Olive (Olea europaea L.) is an oil fruit crop with the physiological potential to survive and produce in rain-fed areas. In Pakistan, it is grown in upper Punjab and Baluchistan due to their climate suitability for better production. Due to the increasing trend of olive oil, peoples show more interest in planting disease-free plants for better oil production. The successful nursery of olives mainly depends on growth substrates with rooting hormones like Indole butyric acid. A recent study was conducted to observe the influence of growing substrate and combination of IBA with zinc sulphate during the vegetative stage of two cultivars of olive. Semi-hardwood olive cuttings were treated with indole butyric acid (IBA) at a level of 3000 ppm with zinc sulphate at 2000 ppm and 3000 ppm and cultured on various types of soil in pots under plastic tunnel conditions under completely randomized design with three factors and each treatment replicated thrice. Both varieties with all treatments significantly affect all traits. The maximum number of shoots were recorded in the media that contain sugarcane press mud with 3000ppm IBA and 3000ppm zinc sulphate that showed the maximum number of shoots (5. 66), branches (6. 66), shoot length (17. 01), number of roots (5. 33), root diameter (0. 23), plant survival percentage (73. 66) and root length (16. 86). In contrast, the minimum number of shoots (1. 0), branches (1. 00), shoot length (3. 77), number of roots (1. 00) root diameter (0. 01), plant survival percentage (44. 33), root length (4. 92) were observed in control media in cultivar Ottobrattica with the treatment of IBA at 3000 ppm+ zinc sulphate 2000 ppm. Results from all treatments revealed a favorable correlation between medium and IBA when combined with zinc sulphate for all measured growth parameters. The 50% sugarcane press mud, 50% silt soil with IBA 3000 ppm+ zinc sulphate 2000 ppm proved to be the best approach for better germination of olive cuttings in pots. The resulting outcomes play a significant role in the better germination percentage under dry climatic conditions. Analysis of variance was used to examine the data obtained (Statistix 8.1). The least significant test (LSD) was used to compare significant means at a 5% probability level.
Design and Implementation of Automated Food-Ration Material Distribution System
Authors: Selvam R.
Published: September 2023

The main aim of this project is to describe the process of developing an automated and competent model of maintenance system for ration distribution using Visual basic program. The prevailing ration distribution system in food industry has large irregularities in the system. This system is user friendly software and will give options to handle staff, stock, purchase, distribution, and center details without any confusion and streamlines the entire process to improve efficiency and productivity. This paper explains the system analysis, software specifications, system design, system testing and implementation of ration distribution system. It is a wonderful package for food corporation to maintain their database and its installation procedure is very easy and provides advanced performance. By using this system, a greater number of staffs can be handled without misperception. The system should generate appropriate reports like staff details, stock, purchase, center, and distribution details.
Effect of Different Pre-Treatments and Temperatures on Drying Characteristics of Beetroot Slices
Authors: Mudgal Deepali , Puja  , Singh Sweta , Singh B. R. , Samsher  , Kumar Pankaj , Sisodia Kamlesh
Published: September 2023

An experimental study was carried out to study the effects of different pretreatments and drying methods on beetroot slices. Drying is widely used and primary method for preservation. Dried beetroot slices were made by treating the slices with different pretreatments (control, KMS, blanching and KMS plus blanching). The drying was done under natural convection in direct sun drying method and under forced convection in cabinet tray drying at temperatures 50⁰C, 60⁰C and 70⁰C. Moisture content, drying rate and moisture ratio were computed to study the drying characteristics of beetroot slices. The study revealed that the highest drying rate and lowest final moisture level was recorded in hot air tray drying of beetroot slices at air temperature of 70⁰C. The total drying time for beetroot slices dried under tray drying at 70°C took 240-360 min to be dried completely depending upon treatments. Sun drying took maximum drying time of 480 min. The increase in drying air temperature increased the drying rate in all the methods.
The Implications of Growth-Regulating Substances on Growth and Yield Traits of Cauliflower
Authors: Gadhiya Dhara , Champaneri Dushyant D. , Patel Naren K.
Published: September 2023

Background: Present investigation was carried out to evaluate the performance of the different levels of GA3 and NAA as foliar spray on growth and yield attributes of cauliflower cv. Pusa Snowball KT-25 at Vegetable Research Farm, Regional Horticultural Research Station, ASPEE College of Horticulture and Forestry, Navsari Agricultural University, Navsari, Gujarat.

Methods: The experiment was framed in Randomized Block Design with three replications, which included nine treatments.

Results: The results revealed that the application of GA3 @ 150 mg l-1 (T5) recorded higher values for growth character viz., plant height (69.26 cm), number of leaves plant-1 (29.67), length of stalk (6.54 cm) as well as plant spread in N-S (69.48 cm) and E-W (71.70 cm). In case of yield attributes, the same treatment GA3 @ 150 mg l-1 (T5) at 40 and 60 DATP exhibited maximum curd diameter (17.80 cm), gross weight of curd (2.88 kg plant-1), net weight of curd (789.59 g plant-1), yield plot-1 (20.23 kg) and yield hectare-1 (31.22 t) followed by NAA @ 80 mg l-1 (T7). Whereas, days to 50 % curd initiation and days to first marketable curd did not show any significant differences.
Rice Blast Forecasting Using Interval Valued Data at Coimbatore, India
Authors: Sandeep N. , Patil S. G. , Gopalakrishnan C. , Vijayabhama M. , Dheebakaran Ga. , A. G. Meena
Published: September 2023

Aims: The persistence of rice blast, caused by the fungus Magnaporthe oryzae, continues to pose a significant threat to rice production worldwide, impacting both yields and food security. The primary goal of this study is to apply interval-valued independent weather data to accurately model the dependent variable of percentage disease incidence.

Study Design: In this paper, we present a detailed study on forecasting rice blast outbreaks through the application of Average method, Center method and Min Max method using interval valued weather data and percentage disease incidence.

Place and Duration of Study: The blast disease data include percent disease incidence (PDI) collected at the Paddy Breeding Station (PBS), Tamil Nadu Agricultural University, Coimbatore, from 2018 to 2021.And Weather variables includes the following: Maximum Temperature, Minimum Temperature, Relative humidity (morning), Relative humidity (evening) from 2018 to 2021.

Methodology: The available interval weather parameter data and disease incidence data are utilized to fit a regression model, specifically employing simple linear regression and multiple linear regression, in the R version 4.3.0.

Results: Upon analyzing various methods, it is evident that the variables of Minimum temperature exhibit a significant relationship with a high level of significance, indicating a significance level at

 P 0.001.

Conclusion: Minimum temperature shows more contribution in disease incidence followed by relative humidity at evening.