bluuebunny/crossref_metadata_2025 huggingface dataset:
Hormone Replacement Therapy Protects Skeletal Muscle by Stabilizing the Neuromuscular Junction in Post-Menopausal Women
Authors: Abutair Maria , Elkhatib Sara , Flayyih Rawan , Alarabid Dalal , Nacer Mohamed , Qaisar Rizwan , Hussain Shah , Ashraf Areesha
Published: October 2024

Introduction: Hormone replacement therapy (HRT) prevents muscle loss associated with menopause; however, the relative role of the neuromuscular junction (NMJ) in post-menopausal women taking HRT is poorly known. We investigate the effects of HRT on plasma C-terminal agrin-fragment-22 (CAF22) in post-menopausal women taking HRT. Methods: We recruited three groups of women, including pre-menopausal (age = 45.3 ± 3.1 years, n = 48) post-menopausal HRT-users (age = 56.7 ± 4.1 years, n = 42) and non-users (age = 55.4 ± 3.9 years, n = 47) for measurements of handgrip strength (HGS), skeletal muscle mass index (SMI), short physical performance battery (SPPB; marker of physical capacity), and plasma CAF22 levels. Results: Post-menopausal non-users of HRT had lower HGS, SMI, gait speed, and SPPB scores and higher plasma CAF22 levels than pre-menopausal women (all p < 0.05). Conversely, HRT users had higher HGS and gait speed and lower plasma CAF22 than non-users among post-menopausal women. HRT users also exhibited SPPB scores similar to those of pre-menopausal women. We observed significant correlations of plasma CAF22 with HGS, gait speed, and total SPPB scores in pre-menopausal and post-menopausal women with HRT (ALL p < 0.05). Lastly, HRT users had lower markers of inflammation and oxidative stress than non-users among post-menopausal women (both p < 0.05). Conclusion: Altogether, menopause was associated with elevated markers of NMJ degradation along with reduced muscle strength and physical capacity. HRT partly reduced NMJ degradation and restored muscle strength and physical capacity in post-menopausal women.
Risk Factors for Colorectal Adenoma and Cancer in Comprehensive Health Checkups: Usefulness of Gamma-Glutamyltransferase
Authors: Yamanouchi Yoko , Osawa Maiko , Senbonmatsu Takaaki , Shiko Yuki , Kawasaki Yohei , Muramatsu Toshihiro
Published: October 2024

Background/Objectives: In this study, we aimed to determine the risk factors for colorectal adenoma/cancer by studying patients who underwent comprehensive health checkups and were referred to a hospital because of positive fecal occult blood. Methods: A total of 529 patients were referred to hospital for a positive fecal occult blood test after a comprehensive health checkup at the participating center over a period of 5 years, from January 2018 to December 2022. Patients diagnosed with colorectal adenoma or cancer using colonoscopy were included in the case group, while those diagnosed with no abnormality, diverticulum, or hemorrhoids were included in the control group. Results: Of the 529 referred patients, 503 underwent colonoscopy. A total of 18 colorectal cancers and 191 colorectal adenomas were detected, and there were no tumors, diverticula, or hemorrhoids in any of the 208 patients. Polyps, either hyperplastic or of unknown pathology, were found in 86 patients. A comparison of the case and control groups showed that gamma-glutamyltransferase (GGT) was an independent and significant risk factor for colorectal adenoma or cancer, in addition to previously known risk factors such as male sex, older age, high body mass index, and alcohol consumption. Conclusions: For patients with a positive fecal occult blood test, in addition to traditional risks such as obesity, older age, male sex, and alcohol consumption, identifying those with high GGT levels is recommended to help find colorectal adenoma/cancer.
Spatial Assets Value Extraction and Integrated Utilization of Old Communities: Case of Central Guangzhou, China
Authors: Yin Xiaoyong , Tang Yiming , Yuan Lei , Ai Yongjun , Tang Yan
Published: October 2024

Extracting the economic value by the integrated utilization of space in old communities is crucial for encouraging independent participation from enterprises and residents, reducing reliance on government leadership and fiscal investment. This study starts from the active perspective of spatial assets and constructs a value activation framework for old communities by balancing “endogenous demand” and “exogenous opportunities”. By enhancing the “economic value” through the “use value”, five methods for value extraction and overall project utilization paths are proposed, guided by a dynamic “cost-revenue” balance. Using multi-source data, we identify the spatial assets of 1096 old communities in central Guangzhou and apply a market comparison method for an economic value assessment. Additionally, this study offers recommendations on the timing and project portfolios for regeneration efforts, along with strategies for establishing a coordinating implementation entity and fund account. This research provides strategic insights for advancing the regeneration of old communities by tapping into their macro-level economic potential.
Social Perception and Engagement in Mangrove Restoration: A Case Study in Central America
Authors: Del Cid-Alvarado Ruth Jasmina , Lopez Omar R. , Rodríguez-González Patricia María , Feás-Vázquez Jacobo
Published: October 2024

Mangroves are vital intertidal ecosystems that support biodiversity and protect coastal communities, but face increasing pressure from anthropogenic activities that sustain local livelihoods. It is crucial to integrate the social dimension into conservation efforts by encouraging community participation in mangrove restoration. Chame Bay, located on the central Pacific coast of Panama, is a protected area with significant mangrove cover, but despite its management plan, degradation continues due to intensive timber extraction for charcoal production and insufficient natural regeneration. This study investigates local knowledge and perceptions of mangrove functions and regeneration. A proportional stratified sampling of the Chame Bay population was used, with 300 interviews conducted among key stakeholders, including residents and mangrove resource users. Variables such as age, education, and profession were analyzed in relation to perceptions, participation, and willingness to participate in restoration efforts. Results indicate that 24.67% of the population’s primary economic activity is charcoal production from mangrove wood, with 15% of producers already involved in restoration and 60% willing to participate. These findings highlight the potential for community-driven restoration and emphasize the need for environmental education to encourage participation. This study provides essential information for designing restoration strategies in mangrove areas in Central America.
Unlocking the Power of Oom and Tannie: How Forms of Address Shape Perception and Respect in Afrikaans
Authors: Ellis Carla
Published: October 2024

Although some research on forms of address toward adults in the South African context has been conducted in the past, there remains a gap regarding the use of oom and tannie as a specific informal Afrikaans form of address. This study comprises both a review of the existing literature and an empirical investigation to address this gap. A mixed-methods approach was used to conduct the empirical investigation. Quantitative data were collected through electronic questionnaires completed by adults and learners. Qualitative data were collected by conducting semi-structured interviews. Analysis of the data indicated that the use of oom and tannie is still prevalent in the Afrikaans-speaking community, demonstrating a high frequency of use. From the data, it becomes evident that age, respect, familiarity, social class, and status serve as determining factors in the use of oom and tannie. The age difference between speaker and addressee that serves as the accepted norm for using oom and tannie remains ten years or more. It seems that the Afrikaans community is moving toward a more informal and solidary society, with oom and tannie or first names being preferred over the use of titles. Without a doubt, oom and tannie are used in the Afrikaans community as alternative forms of respect.
Investigating the Performance of Glass Fibre-Reinforced Polymer (GFRP) in the Marine Environment for Tidal Energy: Velocity, Particle Size, Impact Angle and Exposure Time Effects
Authors: Algaddaime Talal F. , Hassan Emadelddin , Stack Margaret M.
Published: October 2024

Tidal energy, with its potential to provide a consistent energy output and reduce carbon emissions, has garnered significant interest. This study, which evaluates the performance of tidal turbine blades in seawater conditions and with sand particles, presents a novel approach. A slurry rig was developed to examine composite materials, and a glass fibre-reinforcement polymeric material was tested over a range of particle sizes, velocities, and impact angles. In addition, this paper used a new test protocol with 14 days (336 h) and 91 days (2184 h) of pre-exposure time of materials before testing. The results, which show significant changes in the erosive mechanisms of GFRP in short- and long-term pre-exposure time as a function of these variables, have profound implications for the design and performance of tidal turbine blades. The study also utilised scanning electron microscopy (SEM), depth profiling analysis, and erosion mapping techniques to compare the erosion behaviours of GFRP. These tools can be used to optimise such materials in tidal turbine conditions.
A Novel Approach for the Synthesis of 3,3′-((4-Methoxyphenyl)methylene)bis(4-hydroxyfuran-2(5H)-one) Employing Natural Deep Eutectic Solvents and Microwave Irradiation
Authors: Karadendrou Maria-Anna , Kostopoulou Ioanna , Christodoulou Afroditi , Tzani Andromachi , Detsi Anastasia
Published: October 2024

Tetronic acid, a five-membered heterocyclic moiety present in various natural products, has emerged as a significant building block for many pharmaceutically active compounds. In this study, a novel protocol for the synthesis of the bis-tetronic acid 3,3′-((4-methoxyphenyl)methylene)bis(4-hydroxyfuran-2(5H)-one) (3) via a domino Knoevenagel–Michael reaction is presented. The natural deep eutectic solvent L-proline/glycerol 1:2 molar ratio was utilized as a solvent and catalyst, while the reaction was further promoted via microwave irradiation, providing the desired product in high yield (83%). The solvent was successfully recycled and reused up to three times.
Mechanical and Durability Properties of Rubberized Sulfur Concrete Using Waste Tire Crumb Rubber
Authors: Na Okpin , Lee Giyeol
Published: October 2024

The use of rubber crumbs provides a viable solution for alleviating the disposal problem of waste tires. In this study, rubberized sulfur concrete (RSC) was researched to investigate the optimal mixture proportion and to improve the mixing process in terms of compressive strength and durability performance. For the mixture of the RSC, sand, rubber particles, and micro-filler were adopted as aggregates and sulfur was used for the binding material. Moreover, two mixing processes were applied: the dry mixing process and the wet mixing process. Based on the test results, the increment of rubber particles in the mixture led to a decrease in the compressive strength for both the dry and wet mixing processes. To minimize the voids between the sand and rubber particles, the micro-filler was used at 5% of the total volume. The amount of sulfur varied slightly depending on the mixing process: 30% sulfur for the dry mixing process and 34% sulfur for the wet mixing process, respectively. Consequently, compared to the dry mixing process, the wet mixing process increased the bonding force between sulfur and rubber powder due to the simultaneous heating and combining. In toughness, the wet mixing process demonstrates a 40% higher energy absorption capability compared to the dry mixing process. For the durability performance of the RSC, the mixture with 20% rubber particles produced using the wet mixing process exhibited better corrosion and freeze–thaw resistance.
Selective Reduction of Iron in High-Phosphorus Oolitic Ore from the Lisakovsk Deposit
Authors: Suleimen Bakyt , Kosdauletov Nurlybai , Adilov Galymzhan , Gamov Pavel , Salikhov Semen , Kuatbay Yerbol , Zhuniskaliyev Talgat , Kelamanov Bauyrzhan , Yerzhanov Almas , Abdirashit Assylbek
Published: October 2024

Reduction of iron in high-phosphorus oolitic ore from the Lisakovsk deposit using solid carbon, carbon monoxide, and hydrogen. An X-ray phase analysis was used to determine the phase composition of the samples after reduction roasting. When reduced with carbon monoxide or hydrogen, α-iron appears in the samples, while phosphorus remains in the form of iron, calcium, and aluminum phosphates. After roasting with solid carbon, phosphorus is reduced from iron and calcium phosphates and migrates into the metal but remains in aluminum phosphate. A micro X-ray spectral analysis showed that at a temperature of 1000 °C and a holding time of 5 h, during reduction with solid carbon, the phosphorus content in the metallic phase reaches up to 7.1 at. %. When reduced with carbon monoxide under the same conditions, the metallic phase contains only iron, and phosphorus is found only in the oxide phase. When reduced with hydrogen at 800 °C, phosphorus is almost absent in the metallic phase, but at 900 °C, phosphorus is reduced and its content in the metallic phase reaches 2.1 at. %.
Enhancing the Properties of Liquid Crystal Polymers and Elastomers with Nano Magnetic Particles
Authors: Reeves Sarah J. , Patel Dil , Harris Peter J. F. , Mitchell Geoffrey R. , Davis Fred J.
Published: October 2024

Side-chain liquid crystal polymers have been mixed with ferromagnetic particles, and the formation of a monodomain in magnetic fields studied. At relatively low concentrations, the presence of ferroparticles substantially speeds up the rate of formation of a monodomain within the magnetic field, and, at a given concentration of ferroparticles, that rate is independent of the magnetic field’s strength. In this way, the rapid formation of a monodomain is possible at magnetic field strengths far lower those required for the liquid crystal polymer alone. This is anticipated to be very helpful in the fabrication of devices based on monodomain liquid crystal elastomers. Wide-angle x-ray scattering has been used to monitor the formation of the monodomain and small-angle x-ray scattering gives some indication of the ferroparticles’ behaviour. A model is developed to explain their behaviour. The alignment properties of the ferroparticles are related to their ability to form chains under the influence of very low magnetic fields; these chains are of relatively low stability and may become disrupted after long periods of time, high magnetic fields, or high concentrations. In general, the best results for alignment were at volume fractions below 1%, and under these conditions there is the potential for producing monodomain samples with improved properties; in particular, shape changes with temperature are significantly larger as a result of improved backbone orientation. Experiments involving monodomain formation and director realignment suggest that the presence of ferroparticles results in a modification of the mechanism for alignment development, driven by the organization of the polymer backbone, as a consequence of the constraints offered by the morphology of the chains of the ferroparticles.
Evolution of Holes and Cracks in Pre-Carbonized Glassy Carbon
Authors: Yang Yi , Wang Wei , Ruan Haihui
Published: October 2024

Being a type of carbonaceous material, glassy carbon possesses thermomechanical properties akin to ceramics, offering both mechanical and chemical stability at high temperatures; therefore, it can be applied in electrochemistry and high-temperature manufacturing. However, the direct pyrolysis of a bulk precursor leads to internal pores and cracks, usually resulting in fracture. Our characterization results show that at temperatures below 400 °C, large pores do not form, and pre-carbonized glassy carbon (PGC) formed at 350 °C has a dense microstructure without cracks. It exhibits a high compressive strength of ~370 MPa and flexural strength of ~190 MPa, making it suitable for load-bearing applications. Additionally, the PGC-350 material shows small mass loss (~5%) and reasonably low thermal expansion (2.5 × 10−6/°C) when heated to 350 °C again. These properties suggest the potential of PGC for high-temperature applications. As a demonstration, PGC formed at 350 °C was employed to fabricate molds to press chalcogenide glass blanks, which exhibited favorable molding results for various surface morphologies.
Influence of Opening Time Interval of Gate Signals on Suppression of Horizontally Polarized Signal of Infrared Pulsed Laser
Authors: Wu Xinyang , Wang Dongdong , Song Di , Wang Jiaqi , Guo Jiawei , Ren Peng , Cai He , Jin Yaqing , Yu Yonghong , Wang You , Liu Jing
Published: October 2024

Since the beginning of the 21st century, infrared Nd:YVO4 pulsed lasers have been widely applied, especially in some actual industrial processes. In the working process of a laser-aided etching device, the “match-head” effect must be effectively controlled by suppressing the first giant pulse for a solid-state Q-switched laser. In the process of optimizing the infrared Nd:YVO4 pulsed laser by adjusting the slope parameters of the radio frequency (RF) modulation to suppress the first giant pulse, it has been found that an abnormal horizontally polarized emission with a very short time appears before the formal vertically polarized emission when the gate signal is artificially started. Actually, abnormal horizontally polarized emissions will bring some unexpected machining traces during the production process and even greater dangers. The experimental results show that with the increase in the slope duration of an RF signal, the existence time of abnormal output horizontally polarized light will be shortened, and the horizontal giant pulse and vertical giant pulse are well suppressed. When the slope duration is greater than 0.18 ms, both horizontal and vertical giant pulses will disappear. The horizontally polarized light can be thoroughly suppressed when the slope duration is greater than 13.7 ms. Compared with the method of adding a polarizer to eliminate abnormal output horizontally polarized light, this method does not add elements in the laser, ensuring that the laser volume is relatively small, and does not affect the quality of the normal output laser. The research conclusion is thought to be of great practical significance, especially for processing transparent materials.
Influence of Chemical, Morphological, Spectroscopic and Calorimetric Properties of Agroindustrial Cellulose Wastes on Drainage Behavior in Stone Mastic Asphalt Mixtures
Authors: Cabello-Suárez Laura Yessenia , Anzaldo Hernández José , Galaviz-González José Roberto , Avalos-Cueva David , Figueroa Ochoa Edgar Benjamín , Escobar Hernández Daniel , Gallardo-Sánchez Manuel Alberto , Limón-Covarrubias Pedro , Macías-Balleza Emma Rebeca
Published: October 2024

New asphalt mixtures have been improved by using fibers (polypropylene, polyester, asbestos, carbon, glass, nylon, lignin, coconut, sisal, recycled rubber, PET, wood, bamboo, and cellulose), reducing the temperature and compaction energy for their collocation, minimizing the impact on the environment, increasing the tenacity and resistance to cracking of hot mix asphalt (HMA), preventing asphalt drainage in a Stone Mastic Asphalt (SMA). Hence, this paper aims to evaluate the influence of the chemical (lignin content, ash, viscosity, degree of polymerization, and elemental analysis), morphological (SEM), spectroscopic (FTIR-ATR and XRD), and calorimetric (ATG and DSC) properties of celluloses from bagasse Agave tequilana Weber var. Azul (ABP), corrugated paperboard (CPB) and commercial cellulose fiber (CC) as Schellenberg drainage (D) inhibitors of the SMA. The ABP was obtained through a chemical process by alkaline cooking, while CPB by a mechanical refining process. The chemical, morphological, spectroscopic, and calorimetric properties were similar among the analyzed celluloses, but CPB and ABP cellulose are excellent alternatives to CC cellulose for inhibiting drainage. However, CPB is the most effective at low concentrations. This is attributed to its morphology, which includes roughness, waviness, filament length, orientation, and diameter, as well as its lignin content and crystallinity.
Comparative Micro-CT Analysis of Minimally Invasive Endodontic Systems Using 3D-Printed Replicas and Natural Teeth
Authors: Ramírez-Muñoz Ana , Escribano-Capdevila Marta , Navarrete Natalia , Vieira Gaya C. S. , Salamanca-Ramos Marcela , Ortolani-Seltenerich P. S. , Aranguren José , Pérez Alejandro R.
Published: October 2024

(1) Background: This study aimed to compare the shaping abilities of modern minimally invasive endodontic systems using natural teeth and 3D-printed resin replicas. These replicas offer a standardized approach for studying root canal preparation while eliminating the variability and scarcity of natural teeth. (2) Methods: Eleven mandibular molars with Vertucci class IV anatomy and their 3D-printed replicas (n = 132 canals) were scanned using micro-CT before and after preparation with six rotary systems. Shaping abilities were assessed by comparing volume, surface area, and unprepared areas between natural teeth and their 3D replicas, focusing on the apical third. Statistical analysis included the Shapiro–Wilk test to assess data normality and ANOVA and t-tests to compare different endodontic systems. (3) Results: Both qualitative and quantitative analyses revealed high similarity between natural teeth and 3D replicas. No significant differences in volume or surface area were found except in the apical third, where 3D replicas showed slightly larger increases in volume. (4) Conclusions: 3D resin replicas closely mimic natural teeth and provide a practical tool for assessing the shaping abilities of endodontic systems. This study demonstrates that 3D-printed models are suitable for endodontic research, offering a standardized and accessible alternative to natural teeth.
Organic and Inorganic Modifications to Increase the Efficiency in Immobilization of Heavy Metal (Zn) in Cementitious Composites—The Impact of Cement Matrix Pore Network Characteristics
Authors: Kalinowski Maciej , Chilmon Karol , Bogacki Jan , Woyciechowski Piotr
Published: October 2024

This research investigated the properties of modified cementitious composites including water purification from heavy metal—zinc. A new method for characterizing the immobilization properties of tested modifiers was established. Several additions had their properties investigated: biochar (BC), active carbon (AC), nanoparticulate silica (NS), copper slag (CS), iron slag (EAFIS), crushed hazelnut shells (CHS), and lightweight sintered fly ash aggregate (LSFAA). The impact of modifiers on the mechanical and rheological properties of cementitious composites was also studied. It was found that considered additions had a significantly different influence over the investigated properties. The addition of crushed hazelnut shells, although determined as an effective immobilization modifier, significantly deteriorated the mechanical performance of the composite as well as its rheological properties. Modification by iron slag allowed for a significant increase in immobilization properties (five-fold compared to the reference series) without a substantial impact on other properties. The negative effect on immobilization efficiency was observed for nanoparticulate silica modification due to its sealing effect on the pore network of the cement matrix. The capillary pore content in the cement matrix was identified as a parameter significantly influencing the immobilization potential of most considered modifications, except biochar and active carbon.
Encapsulation of Microalgae Tisochrysis lutea Extract in Nanostructured Lipid Carriers (NLCs) and Evaluation of Their Sunscreen, Wound Healing, and Skin Hydration Properties
Authors: Chatzopoulou Natalia , Chaikali Chrysi , Mourkogianni Eleni , Mikelis Constantinos M. , Andriopoulos Vasilis , Kornaros Michael , Avgoustakis Konstantinos , Lamari Fotini N. , Hatziantoniou Sophia
Published: October 2024

Traditional sunscreens have relied on synthetic compounds to protect against harmful ultraviolet (UV) radiation. However, there is increasing interest in utilizing the natural photoprotective properties of microalgae extracts. This approach does not only aim to enhance the stability and efficacy of sun protection formulae but also seeks to reduce the reliance on synthetic sunscreens. This study investigates the encapsulation of Tisochrysis lutea extract (TL) in nanostructured lipid carriers (NLCs) to create a combination (NLC-TL) with enhanced physicochemical stability, antioxidant activity, SPF efficacy, wound healing capacity, and skin hydration. The particle size and ζ-potential were approximately 100 nm and −50 mV, respectively, and both formulations successfully passed the stability tests. The antioxidant activity, measured via DPPH assay, revealed that NLC-TL achieved the highest free radical scavenging activity across all tested concentrations, indicating a synergistic effect. The incorporation of TL in NLCs maintained the sun protection factor (SPF) of a 2% extract solution (1.53 ± 0.13). The wound healing assay indicated that NLC-TLs significantly enhanced wound closure compared to controls and TL alone. Additionally, skin hydration tests on healthy volunteers revealed that NLC-TLs provided superior and sustained hydration effects. These results highlight NLC-TLs’ potential as a multifunctional topical agent for cosmetic and therapeutic applications.
Exploring the Therapeutical Potential of Asparagopsis armata Biomass: A Novel Approach for Acne Vulgaris Treatment
Authors: Januário Adriana P. , Félix Carina , Félix Rafael , Shiels Katie , Murray Patrick , Valentão Patrícia , Lemos Marco F. L.
Published: October 2024

Acne vulgaris, a high-prevalence skin condition afflicting people, persists as a significant challenge in the absence of effective treatments and emerging antibiotic resistance. To address this pressing concern, exploration of innovative approaches is of the utmost importance. Asparagopsis armata, an invasive red seaweed renowned for its diverse array of bioactive compounds, emerges as a promising candidate. This study seeks to elucidate the potential utility of A. armata biomass in the treatment of acne vulgaris. Crude extracts were obtained through solid–liquid extraction, and fractions were obtained using liquid–liquid extraction. The analyzed bioactivities included antioxidant, antimicrobial, and anti-inflammatory. Also, chemical characterization was performed to identify free fatty acids and compounds through LC-MS and elements. The present findings unveil compelling attributes, including anti-Cutibacterium acnes activity, cytotoxic and non-cytotoxic effects, antioxidant properties, and its ability to reduce nitric oxide production with consequent anti-inflammatory potential. Additionally, chemical characterization provides insights into its mineral elements, free fatty acids, and diverse compounds. The observed antimicrobial efficacy may be linked to halogenated compounds and fatty acids. Cytoprotection appears to be associated with the presence of glycerolipids and glycosylated metabolites. Furthermore, its antioxidant activity, coupled with anti-inflammatory properties, can be attributed to phenolic compounds, such as flavonoids. This study underscores the potential of A. armata as a natural ingredient in skincare formulations, offering an important contribution to the ongoing battle against acne vulgaris.
Impact of Hormones and Lifestyle on Oral Health During Pregnancy: A Prospective Observational Regression-Based Study
Authors: Sachelarie Liliana , Iman Ait el haj , Romina Murvai Violeta , Huniadi Anca , Hurjui Loredana Liliana
Published: October 2024

Background and Objectives: This study explores the impact of hormonal fluctuations during pregnancy and lifestyle factors on stomatognathic system (SS) health. The aim is to determine how pregnancy-related hormonal changes and oral hygiene behaviors affect the onset of stomatognathic issues, such as gingival inflammation (GI) and dental erosion (DE). Materials and Methods: A prospective, observational study was conducted with 100 pregnant women, divided into two groups: Group A (60 women with significant stomatognathic alterations) and Group B (40 women without such alterations). Multiple regression analysis was used to evaluate the influence of hormonal levels, oral hygiene habits, and vomiting episodes on stomatognathic health. Results: Age and socioeconomic status showed no significant association with stomatognathic health (p > 0.05). In contrast, elevated levels of estrogen (p = 0.001) and progesterone (p = 0.003) were significantly linked to the severity of stomatognathic changes. Oral hygiene habits also had a statistically significant impact (p = 0.02), while vomiting frequency was not an important factor (p > 0.05). Conclusions: Hormonal changes during pregnancy, particularly increased estrogen and progesterone levels, are key predictors of stomatognathic health. These findings suggest that while oral hygiene is important, hormonal fluctuations play a dominant role in influencing stomatognathic system (SS) health during pregnancy.
The Relationship Between Feelings of Emptiness and Self-Harm Among Thai Patients Exhibiting Borderline Personality Disorder Symptoms: The Mediating Role of the Inner Strengths
Authors: Sripunya Piangdao , Wongpakaran Tinakon , Wongpakaran Nahathai
Published: October 2024

Background and Objectives: Fifty percent of individuals with borderline personality disorder (BPD) experience self-harm. One of the crucial factors related to self-harm is feelings of emptiness. While inner strengths, such as the Five Precepts, meditation, and equanimity, have been identified as potential buffers against negative mental health outcomes in BPD, their role in mediating the relationship between feelings of emptiness and self-harm is not well-documented. This study aimed to explore how these inner strengths mediate the relationship between feelings of emptiness and self-harm in individuals exhibiting BPD symptoms. Materials and Methods: A total of 302 Thai participants exhibiting BPD symptoms completed several assessments: the SCID-II Personality Disorder Questionnaire for BPD to assess feelings of emptiness and self-harm, the Inner-Strength-Based Inventory (i-SBI) to evaluate the Five Precepts, meditation, and equanimity, and the Outcome Inventory Depression (OI-Depression) to assess depression. Mean and standard deviation were used for continuous variables, such as age and OI-Depression. A t-test assessed mean differences in continuous variables between the self-harm group and the non-self-harm group. Chi-square tests examined differences in categorical variables with three or more levels, such as education. Pearson’s correlation and linear regression analyzed relationships between continuous variables, including i-SBI and OI-Depression scores. Mediation analysis was performed using IBM SPSS and AMOS, with self-harm as the outcome variable, feelings of emptiness as the predictor, and inner strengths as mediators. Results: The participants had a mean age of 36.56, with 65.4% being female. The analysis showed that the Five Precepts, meditation, and equanimity significantly mediated the relationship between feelings of emptiness and self-harm, with a standardized coefficient of β = 0.534 (95% CI = 0.417 to 0.647, p < 0.001). The indirect effect of feelings of emptiness through these inner strengths was significant (β = 0.034, 95% CI = 0.009 to 0.075, p = 0.005). The mediation model explained 38% of the variance in self-harm with a 3% increase, albeit small but significant. Conclusions: This study highlights that inner strengths negatively mediate the relationship between feelings of emptiness and self-harm, indicating that as these inner strengths increase, the direct impact of feelings of emptiness on self-harm decreases. These findings suggest that targeting inner strengths as protective factors could be a valuable strategy in developing interventions aimed at reducing self-harm by addressing the underlying emotional challenges associated with BPD.
Genital Attacks in Hereditary Angioedema and Their Effects on Sexual Life
Authors: Camyar Asuman , Bulut Gokten , Ozisik Melih , Altay Sevgi , Tuncel Ozlem Kuman , Ozgul Semiha , Sin Aytul Zerrin , Gokmen Nihal Mete
Published: October 2024

Background and Objectives: Hereditary angioedema (HAE) is characterized by unpredictable skin and mucosal angioedema attacks. We aimed to find the frequency of sexual-activity-triggered attacks (STAs) and understand how the sexual life of HAE with C1-inhibitor deficiency (HAE-C1INH) patients is affected. Materials and Methods: Adult HAE-C1INH patients were included in this cross-sectional study, which started in March 2020. Demographic information, marriage properties, gender-specific sexual life characteristics, and the HAE-specific histories of the patients were collected. The Hospital Anxiety and Depression Scale (HADS) and the Turkish version of the New Sexual Satisfaction Scale (NSSS) were applied to all participants. Results: Among 42 symptomatic HAE patients, 33 (78.57%) had genital attacks and 17 (42.5%) had STAs. Ten (58.8%) had genital pain, tenderness, or swelling, and five (29.4%) had isolated abdominal and groin pain. Eight (47.1%) patients with STAs experienced a HAE attack during their first time engaging in sexual intercourse. Anxiety/depression scales, NSSS scores, and distribution of other HAE attack localizations were similar in patients with and without STAs, and no gender differences were observed. Compared to the patients without STAs, the ratio of patients who stated that their sexual lives were negatively affected and that they lost their sexual desire was higher in patients with STAs. Conclusions: Genital or abdominal attacks triggered by sexual activity may be more common than thought. Sexual activity should also be questioned for evaluating attack triggers. There is a possibility of triggering an attack with the first and ongoing sexual intercourse, and patients should be informed to keep their attack treatment medications ready in advance.
Perspectives and State of the Art of Membrane Separation Technology as a Key Element in the Development of Hydrogen Economy
Authors: Guerrero-Pérez M. Olga
Published: October 2024

Due to the objectives established by the European Union and other countries, hydrogen production will be a key technology in the coming decades. There are several starting materials and procedures for its production. All methods have advantages and disadvantages, and the improvements in their performance and decreases in operational costs will be decisive in determining which of them is implemented. For all cases, including for the storage and transport of hydrogen, membranes determine the performance of the process, as well as the operational costs. The present contribution summarizes the most recent membrane technologies for the main methods of hydrogen production, including the challenges to overcome in each case.
Microstructural and Oxidation Effects of Nb Additions to U3Si2
Authors: Robles Geronimo , White Joshua T. , Widgeon Paisner Scarlett , Sooby Elizabeth S.
Published: October 2024

U3Si2 is a long term, accident-tolerant nuclear fuel candidate for light-water reactors because of its superior thermal conductivity and increased uranium density when compared to traditional uranium dioxide (UO2). While reducing internal thermal stresses and increasing efficiency, U3Si2 exhibits energetic oxidation during certain off-normal and accident scenarios, which include coolant or steam exposure. To mitigate this, Nb is investigated as an alloy constituent to enhance corrosion resistance and increase mechanical strength. The work presented investigates the response of Nb-alloyed U3Si2 to steam atmospheres. A thermogravimetric analysis is conducted in flowing steam to T > 1000 °C to assess oxidation resistance. The phase characterization of as-melted, thermally annealed and post-oxidation compositions with up to 12 vol% Nb by powder X-ray diffraction, scanning electron microscopy, and energy dispersive spectroscopy is reported.
Online Direct Infusion Mass Spectrometry of Liquid–Liquid Extraction Phases for Metabolite and Lipid Profiling with the Direct Infusion Probe
Authors: Marques Cátia , Blaase Lena , Lanekoff Ingela
Published: October 2024

Background/Objectives: Profiling of metabolites and lipids in biological samples can provide invaluable insights into life-sustaining chemical processes. The ability to detect both metabolites and lipids in the same sample can enhance these understandings and connect cellular dynamics. However, simultaneous detection of metabolites and lipids is generally hampered by chromatographic systems tailored to one molecular type. This void can be filled by direct infusion mass spectrometry (MS), where all ionizable molecules can be detected simultaneously. However, in direct infusion MS, the high chemical complexity of biological samples can introduce limitations in detectability due to matrix effects causing ionization suppression. Methods: Decreased sample complexity and increased detectability and molecular coverage was provided by combining our direct infusion probe (DIP) with liquid–liquid extraction (LLE) and directly sampling the different phases for direct infusion. Three commonly used LLE methods for separating lipids and metabolites were evaluated. Results: The butanol–methanol (BUME) method was found to be preferred since it provides high molecular coverage and have low solvent toxicity. The established BUME DIP-MS method was used as a fast and sensitive analysis tool to study chemical changes in insulin-secreting cells upon glucose stimulation. By analyzing the metabolome at distinct time points, down to 1-min apart, we found high dynamics of the intracellular metabolome. Conclusions: The rapid workflow with LLE DIP-MS enables higher sensitivity of phase separated metabolites and lipids. The application of BUME DIP-MS provides novel information on the dynamics of the intracellular metabolome of INS-1 during the two phases of insulin release for both metabolite and lipid classes.
Utilization of Optical OFDM Modulation on Blue LED VLC Datacom Without Equalization for 4 m Wireless Link
Authors: Lin Yuan-Zeng , Yeh Chien-Hung , Lin Wen-Piao , Chow Chi-Wai
Published: October 2024

To achieve higher visible light communication (VLC) traffic capacity, using the wide bandwidth light-emitting diode (LED) and spectral efficiency modulation signal, is currently the most commonly used method. In this demonstration, we apply the orthogonal frequency division multiplexing quadrature amplitude modulation (OFDM-QAM) with bit- and power-loading algorithm on single blue LED to achieve >1 Gbit/s VLC capacity, when a 400 MHz bandwidth avalanche photodiode (APD)-based receiver (Rx) is exploited for decoding. Here, the higher sensitivity APD can be applied to compensate for the wireless VLC link length in the proposed LED VLC system, and due to the lower LED illumination (255 to 40 lux), is used for the indoor access network after passing the wireless link length of 1 to 4 m. As a result, using single blue LED can achieve 0.962 to 1.057 Gbit/s OFDM rate with available 400 MHz bandwidth APD in poorly illuminated condition indoors without applying analogy equalization.
SSPRD: A Shared-Storage-Based Hardware Packet Reordering and Deduplication System for Multipath Transmission in Wide Area Networks
Authors: Ma Jiandong , Guo Zhichuan , Song Mangu
Published: October 2024

To increase bandwidth and overcome packet loss in Wide Area Networks (WANs), per-packet multipath transmission and redundant transmission are increasingly being used as Software-Defined Wide Area Network (SD-WAN) solutions. However, this results in out-of-order and duplicate packets in the destination network. To restore sequential and unique data streams for multiple connections, hardware packet buffers with significant depth are required due to the large delay difference between WAN paths. To address this issue, SSPRD, a shared-storage-based packet reordering and deduplication system using a Field-Programmable Gate Array (FPGA), is proposed. The storage space for packets and sub-buffers is shared by all sessions with dynamic allocation. Packets are stored in the DDR and are sorted by their descriptors in the buffers. We also develop a sub-buffer-based timeout event handling algorithm. While supporting four sessions, SSPRD achieves a deep reorder buffer on hardware, with a depth of up to 15,360 packets per session. Compared with other solutions, SSPRD reduces buffer space usage by 62.5%, and reaches a packet reordering and deduplicating performance of 10 Gbps for 1500-byte packets.
Expanded Graphite as a Superior Anion Host Carrying High Output Voltage (4.62 V) and High Energy Density for Lithium Dual-Ion Batteries
Authors: Salunkhe Tejaswi Tanaji , Kim Il Tae
Published: October 2024

The demand for safer, sustainable, and economical energy storage devices has motivated the development of lithium dual-ion batteries (Li_DIBs) for large-scale storage applications. For the Li_DIBs, expanded graphite (EG) cathodes are valuable as anion intercalation host frameworks to fabricate safer and more cost-effective devices. In this study, three different carbon cathode materials, including microwave-treated expanded graphite (MW-EG), ball-milled expanded graphite (BM-EG), and high-temperature-carbonized carbon nanoflakes (CNFs), were developed by different synthesis methods. Li_DIBs were configured by employing 4 M of LiPF6 in a dimethyl carbonate electrolyte and MW-EG/BM-EG/CNF as an anion host cathode. After 600 cycles, a Li-MW-EG Li_DIB exhibited a reversible capacity of 66.1 mAh/g with a high Coulombic efficiency of 96.2% at a current rate of 0.05 A/g and an outstanding average energy density of 298.97 Wh/kg (with an output voltage of 4.62 V). The remarkable electrochemical results are associated with (i) moderate structural defects with a very low ID/IG ratio (0.848), (ii) degree of graphitization, which improves the mechanical stability and conductivity, and (iii) large pore volume and pore diameter, easy facilitating the accumulation of PF6− ions. The energy density characteristics demonstrate the feasibility of utilizing MW-EG as a promising cathode for energy-related Li_DIB applications.
Silicon Microthermocycler for Point-of-Care Analytical Systems: Modeling, Design, and Fabrication
Authors: Pečar Borut , Zadravec Aljaž , Vrtačnik Danilo , Možek Matej
Published: October 2024

A four-tether silicon microthermocycler for point-of-care PCR analytical systems is proposed. Substituting the commonly employed platinum with titanium in the fabrication of thin film resistance temperature detectors and heaters enabled the realization of a smaller device without compromising temperature accuracy or increasing heater lead power losses. The device was extensively analyzed through analytical modeling and FEM numerical simulations using a 3-D thermo-mechanical simulation model in COMSOL. Numerical simulations revealed that the four-tether design provides a 460% improvement in mechanical strength and a 57% reduction in the thermal time constant compared with a similar three-tether design, with a trade-off of a 22% increase in heat losses. Detailed structural and thermal analyses of crucial design parameters guided the optimization of the final geometry, leading to the successful fabrication of prototypes. It was shown that the current of 60 mA was sufficient to heat the fabricated solid and hollow silicon structure to 132 °C and 134 °C in 10 s for an applied heater power of 510 mW and 525 mW, respectively.
A Multi-Posture Grasping Manipulator Actuated by Shape Memory Alloy with Different Functional Modules
Authors: Li Xiaozheng , Cao Chongjing
Published: October 2024

Currently, multi-posture robots have complex grasping robotic manipulators with low power density, making it difficult to miniaturize and integrate. In this paper, a multi-posture grasping manipulator actuated by shape memory alloy with different functional modules is presented. It is composed of deflection, translation, rotation and grasping modules. Based on a D-H parameter method, the end motion trajectory model is established and the end motion space is drawn. Finally, the grasping experiment of a light circular object is carried out to verify the validity of the multi-posture grasping function of the multi-module combination manipulator, which provides a choice for future intelligent robot manipulators.
Recent Advances in CRISPR/Cas System-Based Biosensors for the Detection of Foodborne Pathogenic Microorganisms
Authors: Xie Sanlei , Yue Yuehong , Yang Fan
Published: October 2024

Foodborne pathogens pose significant risks to food safety. Conventional biochemical detection techniques are facing a series of challenges. In recent years, with the gradual development of CRISPR (clustered regularly interspaced short palindromic repeats) technology, CRISPR/Cas system-based biosensors, a newly emerging technology, have received much attention from researchers because of their supreme flexibility, sensitivity, and specificity. While numerous CRISPR-based biosensors have a broad application in the field of environmental monitoring, food safety, and point-of-care diagnosis, they remain in high demand to summarize recent advances in CRISPR/Cas system-based biosensors for foodborne pathogen detection. In this paper, we briefly classify and discuss the working principles of CRISPR/Cas systems with trans-cleavage activity in applications for the detection of foodborne pathogenic microorganisms. We highlight the current status, the unique feature of each CRISPR system and CRISPR-based biosensing platforms, and the integration of CRISPR-Cas with other techniques, concluding with a discussion of the advantages, disadvantages, and future directions.
Underestimated Incidence Rate of Pertussis in the Community: Results from Active Population-Based Surveillance in Yiwu, China
Authors: Dai Hanying , He Hanqing , Xu Juan , Zhu Yao , Fu Tao , Chen Bohan , Li Jie , Gao Yuan , Qin Aiping , Zhang Maojun , Shao Zhujun
Published: October 2024

Background: The resurgence of pertussis in China underscores the urgency of active surveillance to complement the passive surveillance system. Methods: Active surveillance for pertussis was conducted from 1 June 2021 to 31 May 2022, at Yiwu, Zhejiang province of China. Patients with suspected pertussis were further confirmed as pertussis cases by PCR and culture. The incidence rate of pertussis in the community was estimated. Results: The overall estimated incidence of pertussis was 108.3 per 100,000 (95% CrI: 91.7–126.4). Children aged 4–5 years had the highest incidence (1154.3 per 100,000 [95% CrI: 817.4–1553.5]), followed by infants aged 1 year (836.1 per 100,000 [95% CrI: 434.0–1308.8]). Infants aged 0–4 months had the highest hospitalization rate among the pertussis patients (>50.0%). Although the incidence was low in elderly aged ≥ 60 years, the hospitalization rate was rather high (6.7%). Conclusion: Active surveillance in this study revealed a higher burden of pertussis in Yiwu, China, compared to passive surveillance. Children aged 4–5 years are the dominant population group at risk of pertussis. Infants aged ≤ 4 months are the most vulnerable pertussis patients that require hospitalization treatment. Our results highlight the urgency of large-scale active surveillance of pertussis in China.