bluuebunny/crossref_metadata_2025 huggingface dataset:
Psyhological Response and Ntritional Status of Type 2 Diabetes Mellitus Patients
Authors: Andriani Rizki , Yulia Yulia , Maria Riri
Published: December 2022

The application of nutrient guidelines into daily menu challenges the majority of type 2 diabetes mellitus (T2DM) patients as it needs time to change their dietary habit that has been previously formed. It is common for patients to experience boredom and stress due to their diet program that has to be implemented for the rest of their lives. Psychological response has a great influence in T2DM patients in their effort to control their diet. This research aims to analyze psychological response and nutritional status, also to observe their relationship in T2DM patients. This research uses cross sectional design. It is applied on three type A hospitals in Jakarta by consecutive sampling, with 260 type 2 diabetes mellitus patients as respondents. Questionnaire is used to collect the data. There is a significantly related between psychological response and nutritional status (p = 0.000, OR =4.944) that is not influenced by confounding variable such as anti-diabetic medication, food intake, and age. Respondents with diabetes distress psychological response have 4,944 times higher risk of experiencing abnormal nutritional status compared to respondents without diabetes distress. Regular meeting is needed at least once every four weeks to fulfill psychological needs concerning diabetes.
Kunci Sukses Komunikasi Perawat dalam Upaya Meningkatkan Derajat Kesehatan Masyarakat
Authors: Asmirajanti Mira , Nurhayati Ety , Sari Widia
Published: December 2022

Pendahuluan: Perawat sebagai petugas kesehatan berperan penting dalam peningkatan kesehatan individu, keluarga, dan masyarakat. Perawat harus memberikan informasi dan pendidikan kesehatan secara terus menerus dengan menggunakan komunikasi yang baik. Penelitian ini bertujuan untuk mengidentifikasi komunikasi verbal dan non-verbal perawat dalam upaya peningkatan kesehatan masyarakat.
Metode: Penelitian deskriptif kuantitatif secara potong lintang. Responden dipilih secara purposive sampling dari masyarakat di sekitar Bandung dan Jakarta. Berjumlah 118 orang yang dipilih secara insidental, pernah mendapat pelayanan kesehatan di rumah sakit atau puskesmas, berusia lebih dari 20 tahun. Sebelum pengumpulan data mereka diberikan gambaran tentang komunikasi verbal dan non-verbal. Responden yang bersedia dilanjutkan pada pengumpulan data dengan kuesioner elektronik dan dianalisis secara deskriptif dan statistik inferensial.
Hasil: Median komunikasi verbal dan non-verbal perawat umunya baik, 34.18% dan 19.61%. Median upaya peningkatan kesehatan juga baik, 50.12%. Komunikasi verbal dan non-verbal perawat dalam pemberian pendidikan kesehatan terhadap peningkatan kesehatan masyarakat adalah signifikan (p<0.000) dan berpengaruh yang kuat. Setiap kali perawat memberikan pendidikan kesehatan dengan baik dapat meningkatkan 0.743 kali kesehatan masyarakat.
Kesimpulan dan saran: Komunikasi perawat yang baik pada pendidikan kesehatan akan meningkatkan kesehatan masyarakat. Komunikasi perawat harus terus ditingkatkan. Masyarakat yang telah mendapat pendidikan kesehatan diharapkan dapat memelihara dan mempertahankan kesehatannya sehingga biaya kesehatan efisien.
Daya Hambat Madu Kelulut Dan Daun Belimbing Wuluh Secara In Vitro Terhadap Aktivitas Bakteri pada Luka Post Operasi
Authors: Hasaini Asni , Muhlisoh
Published: December 2022

Indonesia sebagai negara tropis memiliki kekhasan bahan alami yang bersumber dari flora asli dan dapat dimanfaatkan sebagai antimikroba yaitu madu kelulut dan belimbing wuluh. Kedua bahan alami tersebut dapat digunakan untuk menghambat pertumbungan bakteri Pseudomonas Aerugenosa. Metode penelitian ini adalah eksperimen murni laboratoris in vitro dengan pendekatan post test control only design, analisis data dengan Uji Independent Sample Kruskal Wallis dan selanjutnya Uji Post Hoc Mann Whitney. Hasil penelitian dapat disimpulkan adanya perbedaan antara madu kelulut dengan daun belimbing wuluh pada setiap konsentrasi 50% dan 100% terhadap daya hambat bakteri Pseudomonas aeruginosa dengan nilai signifikansi p= < 0,001. Dan berdasarkan uji Mann-Whitney tidak ada perbedaan yang signifikan antara madu kelulut dan daun belimbing wuluh terhadap daya hambat pertumbuhan bakteri Pseudomonas aeruginosa
Efektifitas Media Edukasi Berbasis Audiovisual terhadap Pengetahuan dan Sikap Keluarga Lansia Hipertansi dalam Mencegah COVID-19
Authors: Ni Luh Putu Dian Yunita Sari  , Martini Ni Made Dwi Ayu , Darmaja Ketut , Satryani Ni Luh Susanti , Dewi I Gusti Agung Kumala
Published: December 2022

Background: One of the vulnerable population in the COVID-19 pandemic is the elderly with hypertension. The family as a support system for the elderly in dealing with illness must have good knowledge and attitudes.
Purpose: This study aims to determine the effectiveness of audiovisual-based educational media "Controlling Video" on the knowledge and attitudes of elderly families with hypertension in preventing covid-19.
Research method: This study used a quasi-experimental design with a control group. Purposive sampling was chosen and the number of samples obtained was 64 people. The group was given audiovisual media "Controllers Video" for four weeks via whatsapp, while the control group was given media leaflets after the entire series of interventions was completed. The results of data collection were processed by the Mann-Whitney test after obtaining data that were not normally distributed.
Results: There was a significant difference in the older people family with hypertension (p value <0.001) and there was a significant difference in the attitude of the elderly family with hypertension in preventing COVID-19 between the intervention and control groups (p value = 0.006).
Conclusion: The results of this study can be used as study material to provide family-based interventions in improving efforts to prevent COVID-19.
Pengaruh Edukasi Berbasis Keluarga terhadap Kemampuan Anak Sekolah Mengenal Risiko Cedera
Authors: Rufaida Nur Fitriana
Published: December 2022

Anak usia sekolah dasar merupakan kelompok yang rentan mengalami cedera. Pemahaman mengenaipengenalan risiko cedera dapat diajarkan oleh orang tua. Penelitian ini bertujuan untukmengidentifikasi pengaruh edukasi berbasis keluarga terhadap kemampuan anak mengenal risikocedera pada anak sekolah. Penelitian merupakan penelitian quasi experiment dengan 85 sampel anaksekolah dasar yang didapatkan dengan teknik purposive sampling dan terbagi dalam 2 kelompok. Hasilpenelitian menunjukkan terdapat perbedaan kemampuan mengenal risiko cedera sebelum dan sesudahedukasi dengan nilai p<0.001. Hasil Edukasi berbasis keluarga dapat diaplikasikan sebagai upayapromotive dalam meningkatkan kemampuan anak sekolah mengenal risiko cedera
Exam-Free University Admission: A random Selection Method Based on GPA and in-Class Ranking
Authors: OKTAR Süleyman
Published: December 2022

Today, in order for a student to enter a university, he/she must go through many admission stages. The exam hollowed out the education and expelled the non-cognitive and human values that were not measured by the exam. Exams that completely swallowed the students' 6-18 age period caused disaster in the education system, contrary to their purpose of existence. It has already been observed that standardized exams do not predict university success. The high school Grade Point Average (GPA) is much more related to a student's academic achievement in the university. However, the inconsistency of high school GPAs between schools restricts their direct use of it at the university entrance. Our suggestion is to make random selection based on high school GPA. A lottery coefficient will be given to each student by using the student's high school GPA, class GPA, and class ranking. Thus, students will enter random selection with a lottery coefficient based on school success. Those with high success will have a higher coefficient and those with low success will have a lower coefficient. We hope that the random selection method will provide students with opportunities for their non-cognitive development and contribute to social peace.
Development of a Facial Recognition-based Attendance System using Binary Patterns Histograms Method and Telegram Bot Notification
Authors: Fauzan Qois Amin , Budianto Aris , Budiyanto Cucuk Wawan
Published: December 2022

In carrying out attendance activities, most schools still use the manual attendance method, which utilizes the attendance book as a medium. However, the presence of the manual still causes some problems that arise when using this method. With the aim of this study, a "Facial Recognition-Based Attendance System" was created. This study used the Local Binary Pattern Histogram (LBPH) method to detect and recognize faces. The system is made to recognize the student's face and name, which the attendance system will then carry out along with the student's identity in the form of Name and Absence Number in real time to find out that the student is present in the class. The names that have been diabase can be saved through the XLS format. The result of this study is a facial recognition-based attendance system using the LBPH (Local Binary Pattern Histogram) method. The system is web-based, so users can easily access it through the internet. This research method uses research and development methods. This research stage consists of research and information collection, planning, and product draft development. The results of this study showed the feasibility level of facial recognition-based attendance systems. The eligibility rate obtained showed a score of 78.98%. From these results, this system is worthy of being used as an attendance system.
Evaluasi Penerapan ChatBot Telegram dalam Pembelajaran Dasar-dasar Kejuruan Menggunakan Gibb's Reflective Learning Cycle
Authors: Fauziyah Farah , Budiyanto Cucuk Wawan , Lestari Muji
Published: December 2022

Interaksi antara guru dan peserta didik atau antara peserta didik di kelas memainkan peran besar dalam keterlibatan selama pembelajaran. Kelas pasif akan menghambat pelestarian motivasi, dan perkembangan kognitif. Guru sebagai fasilitator pembelajaran harus memiliki kemampuan untuk membuat pembelajaran menjadi interaktif dimana siswa terlibat aktif dalam kegiatan pembelajaran. Dengan menerapkan chatbot telegram sebagai media interaksi dalam pembelajaran membuat pembelajaran menjadi lebih aktif karena media ini memunculkan interaksi yang baik antar siswa. Penelitian ini bertujuan untuk memahami persepsi guru dan siswa terhadap penerapan aplikasi ChatBot Telegram sebagai media interaksi dalam pembelajaran. Penelitian ini menggunakan pendekatan kualitatif dengan teknik refleksi sebagai metode untuk menangkap persepsi dari guru dan siswa. Siklus Belajar Reflektif Gibb digunakan dalam mengevaluasi proses pembelajaran Berbeda dengan penelitian sebelumnya, penelitian ini menerapkan teknik penilaian 360 derajat yang berasal dari guru dan peserta didik untuk mengevaluasi kinerja penggunaan teknologi dalam proses pembelajaran.
An ecological analysis to examine stigma and undiagnosed HIV infections among men who have sex with men (MSM) in the United States, National HIV Behavioral Surveillance System, 2017
Authors: Babel Riddhi Ashok , Alessi Edward J , Al-Tayyib Alia , Kuo Irene , Opoku Jenevieve , Tate Ashley , Fahad Anindita , Wogayehu Afework , Orellana Roberto , Wei Chongyi , Raymond Henry F
Published: December 2022

Background: Studies have been conducted to assess the prevalence of undiagnosed HIV infections however, at present, there is no study that compares and evaluates the association of perceived HIV stigma, gay related enacted stigma, and undiagnosed HIV infections among MSM by geographic region in the United States (U.S). This ecological study identifies clusters of cities with similar stigma measures in the U.S.
Methods: We conducted the analysis using data from National HIV Behavioral Surveillance (NHBS) collected during the 2017 MSM cycle. We used unsupervised machine learning procedure known as k-means clustering to identify clusters of cities with similar stigma measures. We also examined correlations between percentages of undiagnosed HIV infections both with perceived HIV stigma and gay related enacted stigma. In addition, we used American Community Survey (ACS), 2013-2017, data to characterize each city in terms of key population level characteristics.
Results: Cities were grouped in two distinct clusters after the implementation of the clustering technique; each cluster was different in terms of their racial makeup. There was a moderate correlation (0.50) between percentage of perceived HIV stigma and undiagnosed HIV infections and a low correlation (0.23) between percentage of gay related enacted stigma and undiagnosed HIV infections among MSM.
Conclusion: Stigma reduction interventions should be tailored by city to address the underlying HIV burden among MSM communities. This will not only improve the health of the MSM communities but the larger community as a whole. Future studies should include more cities from the Southern U.S and examine how stigma affects MSM populations, especially of color.
Are the common genetic 3’UTR variants in ADME genes playing a role in tolerance of breast cancer chemotherapy?
Authors: Tęcza Karolina Tęcza , Kalinowska Magdalena Kalinowska-Herok , Łanuszewska Joanna Łanuszewska , Pamuła Jolanta Pamuła-Piłat
Published: December 2022

We described associations among 3’UTR genetic variants in ADME genes, clinical factors and the risk of toxicity or side effects of breast cancer chemotherapy. The SNPs in breast cancer women were tested in relation to 12 symptoms belonging to myelotoxicity (anemia, leukopenia, neutropenia), gastrointestinal side effects (vomiting, nausea), nephrotoxicity and hepatotoxicity, occurred in overall, early or recurrent settings. The cumulative risk of overall symptoms of anemia was connected with AKR1C3 rs3209896 AG, ERCC1 rs3212986 GT and > 6 cycles of chemotherapy; leucopenia was determined by ABCC1 rs129081 allele G and DPYD rs291593 allele T; neutropenia risk correlated with accumulation of genetic variants of DPYD rs291583 allele G, ABCB1 rs17064 AT and positive HER2 status. Risk of nephrotoxicity was determined by homozygote DPYD rs291593, homozygote AKR1C3 rs3209896, postmenopausal age and negative ER status. Increased risk of hepatotoxicity was connected with NR1/2 rs3732359 allele G, postmenopausal age and with present metastases. The risk of nausea and vomiting was linked to several genetic factors and premenopausal age. We concluded that chemotherapy tolerance emerges from the simultaneous interaction of many genetic and clinical factors.
Opportunities, Progress and Challenges in Carbon Emission Pricing and Markets for East and South African Regions
Authors: Maumoh Immaculate , Onoja Anthony , Alhassan Iddisah , MUHIDEEN SAYIBU
Published: December 2022

In this study, we focus on (i) CO2 emissions among selected Southern and West African countries from 1990–2019 (ii) the relevance of carbon pricing and markets to regional economic growth and climate change mitigation, especially in Sub-Saharan Africa. We then (iii) document progress made in the Southern and Eastern African carbon emission pricing and markets in line with the Paris Agreement 2015, as well as recent achievements regarding long expected replenishment of the Green Climate Fund (GCF); (iv) provide some policy designs and pitfalls against effective carbon pricing system in Southern and Eastern Africa. The study used an in-depth review of relevant literature and secondary sources from the CCAFS NDC sub-sector database 2021. Data were classified and quantified by sub-sector measurement. The results found reasonable progress in the Eastern and Southern African regions to advance Carbon Pricing with magnitudes surpassing the West African regions. South Africa leads in terms of implementing initiatives that will establish carbon pricing. Although not well harnessed and modified, there are considerable opportunities in carbon trading in Africa. However, noted that several initiatives aimed at ensuring green economic growth that can be linked to carbon prices exist in the study region, and they primarily include incentives including: carbon taxes, levies, and taxes, the establishment of trading platforms to sell carbon credits, research funding to deepen knowledge and awareness on carbon trading status among other legislative initiatives. Challenges repressing growth and development of carbon pricing in the regions include poor political will and frameworks on climate change mitigation evidenced in the insufficient number of legislations addressing the issue; inadequate capacity of the policymakers and countries experts to conceptualize and implement carbon pricing policies, and a general lack of financial systems and financial resources to promote climate change mitigation activities. Five relevant recommendations were made based on the findings.
Probing electron localization during molecular dissociation by femtosecond strong-field ion momentum spectroscopy
Authors: Luo Sizuo , Zhao Xinning , Xu Ting , Yu Xitao , Ren Dianxiang , Li Mingxuan , Zhang Xinyu , Li Xiaokai , Ma Pan , Zhang Dongdong , Wang Chuncheng , Wang Qinxin , Hu Xiaoqing , Wu Yong , Wang Jianguo , Ding Dajun
Published: December 2022

The study of the dynamics of molecular valence electrons and their coupling with nucleus motion is a frontier in ultrafast physics and ultrafast chemistry. Here, we investigate the behavior of valence electrons and nucleus wavepackets on a femtosecond time scale by the time-resolved strong-field ion momentum spectroscopy. Two orientation-dependent bond-breakages of N2O molecules from the same electronic state are studied, and the evolution of dipole moment during molecular breaking on the asymmetric Pzsum distribution is analyzed, and thus the electron localization during the molecules dissociating into ions and atoms is captured. The overall agreement between experimental and theoretical results for the orientation-dependent dissociation dynamics promotes the understanding of the evolution of nucleus wavepackets and provides a basis for the control of molecular ultrafast chemical reactions.
Acoustic emission characteristics and failure mode analysis under constant stress lower limit uniaxial cyclic loading and unloading of shale
Authors: GAUTAM PRADEEP KUMAR
Published: December 2022

In this paper, we investigated to quantify the mechanical damage of shale specimens based on the Kaiser effect during different uniaxial cyclic loading-unloading rates (0.5, 1.0, 1.5, 2.0, and 2.5kN/s) with the stress level increasing under constant stress lower limit uniaxial cyclic loading and unloading. The time-dependent stress-strain curve, acoustic emission (AE) amplitude, accumulated AE count, cumulative AE energy, and the spatiotemporal evolution of AE event scattering behavior were determined. The study found that below 1.0kN/s low-stress unloading has few AE activities, while above 1.5kN/s high-stress unloading has many AE activities. These effects were seen throughout the loading-unloading cycle, with the Felicity ratio (FR) decreasing with the next cycle number. The Kaiser effect occurs in the linear elastic stage, while the Felicity effect occurs in the elastoplastic yield and post-failure stages. Furthermore, the FR variations during shale deformation and failure can be divided into four phases: (Phase I= 1.01 ≥ FR > 0.89), (Phase II= 0.89 ≥ FR > 0.48), (Phase III= 0.48 ≥ FR > 0.23), and (Phase IV= FR ≤ 0.23). But after the third cycle, the number of cracks and fractures increases rapidly, then decreases gradually until the rupture failure. These damage indices can be used to shale's deformation and failure mechanisms under complex time-dependent loading-unloading conditions.
Targeted linked-read sequencing for direct haplotype phasing of parental GJB2/SLC26A4 alleles: A universal and dependable noninvasive prenatal diagnosis method applied to autosomal recessive nonsyndromic hearing loss in at-risk families
Authors: Gao Bo , Jiang Yi , Han Mingyu , Ji Xiaowen , Zhang Dejun , Wu Lihua , Gao Xue , Huang Shasha , Zhao Chaoyue , Su Yu , Yang Suyan , Zhang Xin , Liu Na , Han Lu , Wang Lihai , Ren Lina , Yang Jinyuan , Wu Jian , Yuan Yongyi , Dai Pu
Published: December 2022

Background
Noninvasive prenatal diagnosis (NIPD) for autosomal recessive nonsyndromic hearing loss (ARNSHL) was rarely reported until recent years. However, previous method would be unavailable without the proband genotype or challenging genome loci(e.g. CNV, deletions, inversions, or gene recombinants). Here, We assess the performance of relative haplotype dosage analysis (RHDO) - based NIPD for identifying fetal genotyping of pregnancies at risk of ARNSHL.
Methods
Fifty couples carrying pathogenic variants associated with ARNSHL in either GJB2 or SLC26A4 were recruited. The fetal cell-free DNA (cfDNA) of 49 families that met the quality control standard was genotyped using RHDO-based targeted linked-read sequencing. Fetal amniocyte samples were genotyped by invasive prenatal diagnosis (IPD) to evaluate the performance of NIPD.
Results
The 49 fetal genotypes were identified as 14 normal homozygotes, 17 heterozygotes, and 18 affected homozygotes or compound heterozygotes by NIPD, which were all concordant with those diagnosed by IPD. The concordance rate was 100% for the GJB2 (31/31) as well as SLC26A4 (18/18) genotyping. The sensitivity and specificity were both 100%.
Conclusions
Sufficient specific informative SNPs for haplotyping, the fetal cfDNA concentration as well as the sequencing depth are prerequisites for the RHDO-based NIPD, which has the merits of being proband-free and qualified for copy number variation analysis, thus it is suitable for universal application. It also has clinical potential as an alternative to traditional IPD for ARNSHL.
pH changes of root dentin following root canal filling with three different calcium silicate-based cements over 4-week period
Authors: Kaewkiew Kessara , Chaimanakarn Chitpol
Published: December 2022

Objective

To evaluate the pH changes of root dentin after root canal filled with ProRoot MTA, Bio-MA or Biodentine at different root levels and times.

Materials and methods

53 extracted single-rooted mandibular premolars were instrumented. Three different locations of cavities were prepared on the root surface at the apical and the middle levels. Three experimental groups (n = 16) were filled with ProRoot MTA, Bio-MA or Biodentine. A control group (n = 5) was filled with deionized water. The pH in cavities was measured at the following time points (2 hours, 1 day, 1–4 weeks). Three-way mixed ANOVA was used to analyze (p-value < 0.05).

Results

Significant pH changes to alkaline pH occurred over 4-week period in experimental groups at all root levels (p < .001). The Bio-MA group showed the highest pH value (9.18) at 1 day and 1 week at the apical and inner middle root levels. The highest pH value of ProRoot MTA and Biodentine groups were 9.12 and 9.07 at 2 weeks and 2 hours at the inner middle and apical root levels, respectively. The pH values at the outer middle root level are the lowest.

Conclusions

The pH changes of root dentin to alkaline pH were found for 4 weeks. The highest pH values were 9.07–9.18. The outer middle root level displayed lowest pH values.

Clinical Relevance

Root canal filled with calcium silicate-based cement provided long term alkaline pH of root dentin, being considered in the conditions for antibacterial effect and treatment of external inflammatory root resorption.
An inquisitive search for Bhasma (A herbo-mineral Ayurveda medicine) as a drug delivery vehicle candidate.
Authors: Rajan Mariappan , Verma Shruti , Sharma Rohit , Talwar Sangeeta , Kumar Avanish , Agrawal Trapti , gupta prashant kumar
Published: December 2022

Nano-formulations of Gold (Au) are proven drug delivery vehicles. Ayurveda i.e. Indian traditional medicine system, involves metalBhasmas(like Au, Ag, Fe, Cu) for therapeutic purposes. Ayurveda literature prompts Gold Bhasma/Incinerated Gold Particle (InGPs) synergizes the co-administered drug and/or act as a drug delivery vehicle. Comparative physicochemical and drug encapsulation and release pattern analysis of Gold Nanoparticles (AuNPs) and InGPs was performed to test the above statement. We have loaded Rifamycin (RF) and Isoniazid (INH) over AuNPs, and InGPs, with and without nano-carrier, and checked their encapsulation and release pattern. Interestingly, Gold Bhasma has a high entrapment, and encapsulation compared to a gold nanoparticle. InGPs with a carrier(InGP + Cs) have shown increased retention capacity compared to AuNPs with a carrier(AuNP + Cs). The cumulative releasing pattern of RF/INH from AuNPs + Cs was faster than InGP + Cs suggesting the InGPs have higher drug holding capacity. InGPs with or without polymeric carriers have good entrapment and retention capacity. Obtained results demonstrate that InGPs could have more significant value and practical application in the loading and delivery of antibiotics that further indicate to address antibacterial problems effectively, especially in the case of drug resistance. With this short communication, our motto is to bring this interesting and valuable information quickly to the nano-medicine community. We elicit this appealing information that goldBhasmacould be further explored and speed up its potentiating inhibitory effects of existing antibiotics against drug-resistant bacteria and improve sustained release antibiotic delivery.
THz properties of two food additives sodium solution based on microfluidic chips
Authors: Peng Bo , Qian Siyu , Zhang Boyan , Li Qingjun , Su Bo , Cui Hailin , Zhang Shengbo , Zhang Cunlin
Published: December 2022

The vibration and rotation energy levels of many molecules are in the terahertz (THz) band, so THz spectroscopy can be used to qualitatively identify substances. However, the terahertz spectrum of most molecules in aqueous solution is completely different from that of solid molecules, and they have strong absorption characteristics for terahertz waves. Therefore, how to reduce the absorption of water for THz wave has become an urgent problem to be solved. Food additives are our daily necessities. They can extend the shelf life of food. In this study, a microfluidic chip with very low THz wave absorption was designed, and the THz transmission spectra of food-additive sodium hexametaphosphate solution and sodium pyrophosphate solution were measured using THz time domain spectroscopy (THz-TDS) system. The experimental results show that the THz spectral intensity of the two sodium salt solutions increases with the increase of solution concentration, which is completely contrary to the phenomenon of common sodium salts, such as sodium chloride. It shows that the process of ion hydration affects the hydrogen bond between water molecules and changes the absorption of THz waves by water. This method lays a foundation for further study of the THz characteristics of electrolyte solutions.
The use of traditional medicine practitioners for childhood illness among childbearing women: a multi-level Analysis of Demographic and Health Surveys in 32 sub-Saharan African countries
Authors: James Peter Bai , Gyasi Razak M. , Kasilo Ossy Muganga Julius , Wardle Jon , Bah Abdulai Jawo , Yendewa George A , Mwaka Amos Deogratius
Published: December 2022

Background: Understanding traditional medicine practitioners (TMP)-seeking behaviour for childhood diseases may be important to reducing child mortality. However, a comprehensive picture of TMP utilisation and its associated factors for childhood illness in sub-Saharan Africa (SSA) is lacking. This study aimed to estimate the prevalence of women with children under five years old who sought the service of a traditional medicine practitioner to treat their children’s illness and identify individual and community-level factors associated with such a pattern of use.
Methods
We utilised extracted Demographic and Health Surveys (DHS) data collected between 2010 and 2021 among 353,463 under-fives children from 32 SSA countries. Our outcome variable was the use of TMP for childhood illness (diarrhoea or fever/cough or both). We used STATA v14 to conduct descriptive, bivariate, and two-level multivariable multi-level modelling.
Results
Approximately [2.80% (95%CI: 1.88-3.90)] women who sought healthcare for childhood illnesses utilised the service of a TMP with the highest in Ivory coast [16.3% (95%CI: 13.87-19.06)] followed by Guinea (13.80% (95%CI: 10.74-17.57)] to the lowest in Sierra Leone [0.10%(95%CI:0.01-1.61)]. Specifically, approximately [1.95% (95%CI: 1.33-2.68)] and [1.09% (95%CI: 0.67-1.60)] women sought the service of a TMP for childhood diarrhea and fever/cough, respectively. Women with no formal education [AOR=1.62;95%CI:1.23-2.12], no media access [AOR=1.19;95%CI:1.02-1.39), who lived in a household headed by a man [AOR=1.64;95%CI:1.27-2.11],without health insurance [AOR=2.37;95%CI: 1.53-3.66], who considered it a problem getting permission to visit a health facility [AOR=1.23;95%CI:1.03-1.47] and perceived the size of their children at birth to be above average[AOR=1.20;95%CI:1.03-1.41] had higher odds of using TMP for childhood illness.
Conclusion
Despite the low usage of TMP for childhood illness, our findings highlight that TMPs continue to have a role in managing childhood illness in SSA. It is essential that policymakers and service providers consider the potential role of TMPs in designing, reviewing and implementing child health policies and interventions in SSA. Also, child health policies and interventions should be focused on the characteristics of women who use TMPs for childhood diseases identified in our study.
Annonaceous acetogenins: A computational study into their antitumor activity in multidrug resistant enzymes
Authors: Alanzi AbdullAllah , Moussa Ashaimaa Y.
Published: December 2022

Natural products that could reverse tumor drug resistance are promising and highly appreciated; especially, if they are part of combination therapy with conventional anti-cancer drugs. Acetogenins, the long chain polyketide derived fatty acids, from Annona squamosa and muricata were screened in the last 20 years and promising compounds were selected to investigate their activity by computational studies inside the binding pockets of four major MDR enzymes (EGFR, MCL-1, BCL-2, and NQO1). Using virtual screening and molecular docking, compounds were ranked according to their fitting scores and squamostanin A, annupupuricin, Squamocin IV were the best fitting molecules with favorable non covalent interactions with key amino acids compared to native ligands and standards. Subsequently, these compounds in their prepared enzyme complexes were subjected to molecular dynamics stability study to investigate the complex characteristics. The key interactions were confirmed in the molecular dynamic study, which manifested no noticeable unfolding of the binding complexes. The physicochemical and drug likeness properties of all the compounds were evaluated through the QikProp module indicating their suitable ADMET properties within the recommended ranges.
A New, Alternative Risk Score for Sarcopenia in Chinese Patients with Type 2 Diabetes Mellitus
Authors: He Qinghua , Wang Xiuzhi , Yang Caizhe , Zhuang Xiaoming , Yue Yanfen , Jing Hongjiang , Hu Jing , Sun Mingxiao , Guo Lixin
Published: December 2022

Objective
To develop a new, alternative sarcopenia risk score to screen for sarcopenia in type 2 diabetes patients in China and to demonstrate its validity.
Research design and methods
: The data for this study came from a multicenter, cross-sectional study that had been designed to estimate the prevalence of sarcopenia among adults with type 2 diabetes and had been conducted in several hospitals in Beijing, China. A total of 1125 participants were randomly divided into two groups: an exploratory population and a validation population. A multivariable logistic regression model using the backward stepwise likelihood ratio method to estimate the probability of sarcopenia was fitted with candidate variables in the exploratory population. A new, alternative sarcopenia risk score was developed based on the multivariable model. The internal and external validations were performed in the exploratory and validation populations. The study was registered at Chinese Clinical Trial Registry (ChiCTR-EOC-15006901).
Results
The new, alternative sarcopenia risk score included seven variables: age, sex, BMI, glycosylated hemoglobin, insulin treatment or not, total caloric intake per day, and the proportion of calorie supplied by protein. The score ranged from − 9 to 23. The area under the receiver operating characteristic (ROC) curve of the risk score for the prediction of sarcopenia in type 2 diabetes patients was 0.812 (95% CI 0.748–0.877) and 0.841 (95% CI 0.785–0.897) in the exploratory and validation populations, respectively. At the optimal cutoff value of 11, the sensitivity and specificity of the score for the prediction of sarcopenia were 74.5% and 78.0% in the exploratory population and 80.5% and 72.2% in the validation population, respectively. The Hosmer-Lemeshow goodness-of-fit test showed a good calibration with the risk score in external validation (χ2 = 1.687, P = 0.989).
Conclusions
The new, alternative sarcopenia risk score appears to be an effective screening tool for the identification of sarcopenia in Chinese patients with type 2 diabetes in clinical practice.
Development Of A New Nanosensor For The Determination Of Food Coloring Sunset Yellow In Powder Drinks Using L-Cysteine Coated Copper Nanoclusters
Authors: Bilkay Mehmetcan , Karataş Büşra , Kara Hayriye Eda Satana
Published: December 2022

Sunset Yellow (SY) is an artificial colorant containing an azo group. The high stability and low cost of SY make it more preferable. Excessive consumption of SY, which is used to improve the appearance of foods, has harmful effects. The most important of these effects are cancer and hyperactivity disorder. Therefore, determination of SY in foods is extremely important for human health. In this method, L-cysteine ​​coated copper nanoclusters (CuNCs) were used as a fluorescence probe. L-cysteine ​​has been used as both a reducing and stabilizing agent. One-step green hydrothermal synthesis of CuNCs was made. L-cysteine-coated CuNCs have been characterized using several of methods. CuNCs quenching mechanism is static and inner filter effect (IFE). The linear range is 0.65-14 µg.ml− 1 at optimum conditions. LOD and LOQ values ​​were calculated as 0.1–0.35 µg.ml− 1, respectively. The proposed method was used for the determination of SY in different type of powder drinks. The developed nanosensor is environmentally friendly, easy, fast, reproducible, and low cost.
The role of TOP2A in immunotherapy and Vasculogenic mimicry in non-small cell lung cancer and its potential mechanism
Authors: wu Jiatao , Zhang Lei , Li wenjuan , Wang Luyao , Li Kairui , Shi Fan , Jia Qianhao , Liao Lingli , Shi Yuqi , Wu Shiwu
Published: December 2022

Background: Type IIA topoisomerase (TOP2A) is significantly associated with malignant tumor development, invasion, treatment and its prognosis, and has been shown to be a therapeutic target against cancer. In contrast, the role of TOP2A in the immunotherapy of non-small cell lung cancer as well as in VM formation and its potential mechanisms are unclear.
Methods: Based on the 82 significantly co-expressed genes of TOP2A screened, consensus molecular typing was performed by the NMF algorithm, and the effect of immunotherapy was further evaluated in two groups of patients with high and low risk. The expression of TOP2A and VM in non-small cell lung cancer tissues was assessed by immunohistochemistry. Western Blot, colony formation assay, CCK8 assay, cell cycle and apoptosis assay, tube-forming assay and cytoskeleton staining were used to verify the role of TOP2A in proliferation, skeleton regulation, motility and VM generation in non-small cell lung cancer and its mechanism.
Results: Patients with lung adenocarcinoma were distinguished into high- and low-risk subgroups based on significant co-expression of TOP2A genes. Subgroup analysis showed that patients in the low-risk group had a better prognosis, while higher risk was associated with higher tumor mutational load, M1-type macrophage and immune checkpoint molecule expression. The Tumor Immune Dysfunction and Rejection (TIDE) and Tumor Immunome Atlas (TCIA) databases also showed significant differences in the outcome of immunotherapy in patients with different types of lung adenocarcinoma. As verified by further clinical specimens, the presence of both TOP2A and VM were significantly and positively correlated with poor prognosis. TOP2A may ultimately affect immunotherapy and VM formation in non-small cell lung cancer through its involvement in regulating the expression of Wnt3a and PD-L1.
Conclusion: A model based on significantly co-expressed genes of TOP2A was significantly correlated with mutational load and immunotherapeutic effects in patients with non-small cell lung cancer. TOP2A plays an important role in immunotherapy and VM formation in non-small cell lung cancer through upregulation of Wnt3a and PD-L1 expression.
The switching process of trailing edge dominant tones on the different ladders
Authors: Song Zhangchen , Liu Peiqing , Guo Hao , Qu Qiulin , Hu Tianxiang
Published: December 2022

Airfoil trailing edge noise in low-to-moderate Reynolds number has multiple tonal noise. The frequency of the dominant tone has a ladder structure for the dependency on the free stream velocity, while the presence of the secondary tones is explained as an amplitude modulation by the primary single tone. However, during the jumping process, when the main tone is selected from two nearly equal strength tonal noise on the different ladders, the choice of the main tone and amplitude modulation theory are poorly investigated and lacks specific experiments at present. Hence, the switching process of trailing edge dominant tones of a NACA0012 airfoil at a Reynold number of around 130,000 is focused on by a simultaneous measurement of microphone and hot-wires at Beihang D7 aeroacoustics wind tunnel. The far field noise measurement confirms presence of two tones on time-average with a velocity range from 19.8m/s to 20.2m/s. For a freestream velocity of 20m/s, after selecting the time span by short-term Fourier transform, the wavelet contour maps of microphone present a random selection of the strongest tone, which is a switching tones pattern contradictory to the periodic amplitude modulation of only one tone. The simultaneous measurement results by two hotwires also show similar patterns with differences on the spanwise locations. This non-uniform spanwise alternation between frequencies rather than a consistent modification along the spanwise direction might contribute to the switching tones pattern in the microphone signals. A statistical analysis of the occurrence of two tones indicates that the switching tones pattern in sound pressure signals is greatly influenced by the spatial distribution of velocity on the spanwise direction as sound sources during the jumping process.
Do Hip and Ankle Strength as well as Range of Motion Predict Y-Balance Test - Lower Quarter Performance in Healthy Males?
Authors: Olszewski Maciej , Zając Bartosz , Mika Anna , Golec Joanna
Published: December 2022

The study aim was to evaluate associations between hip and ankle strength, ROM and YBT-LQ. The study involved 66 healthy males (age: 25.2+6.8 years). Each participant was assessed with ankle DF ROM, hip IR ROM, ER ROM and hip ABD, EXT and ER muscle isometric strength. The YBT-LQ test was performed for both limbs (stance and kicking leg). Forward two-step multiple linear regression analysis was performed to determine relationships between a predictor set and the criterion variable. Of 6 input variables for regression models, only 2 (ankle DF ROM, hip ABD strength) explained variance of YBT-LQ performance. Variance for anterior, posteromedial (PM) and posterolateral (PL) reach distances were explained from R2 = 0.15 to R2 = 0.49, but the models’ composition in PM and PL differed between legs. YBT-LQ composite score in both legs was explained by the same model, including ankle DF ROM and hip ABD (R2 = 0.44; R2 = 0.25). Hip ABD strength and ankle DF ROM assessment may be useful in individuals with poor YBT-LQ test performance to detect specific musculoskeletal deficits. Moreover, the regression models in stance leg for all reaches and composite score were more predictive than for the kicking leg.
An Availability Design to Capture Heterogeneous Decision Rules: a Case Study for Airfare Choice
Authors: Wang Jue , Smith Brett
Published: December 2022

In choice behaviour studies, decision makers are generally assumed to process all information for each available alternative and can choose by trading-off attributes at the margin. In many choice contexts, decision makers may employ alternative heuristics and we argue that this is likely to apply in airline itinerary choices. A population of choice makers employing multiple decision rules combined with heterogeneous preferences presents an added layer of complexity to the estimation of demand. This study presents an availability stated preference design aimed to differentiate decision rules used decision makers and, subsequently, provide more accurate demand responses. The empirical study reveals that air travellers apply different decision rules when choosing an airfare. Most adopt choice heuristics, such as non-trading (i.e. choosing the same carrier or fare class always) and lexicographic ordering on price. Identification of these rules leads to a better understanding of consumers’ airfare choice behaviour. Ignoring multiple decision rules leads to misguided yield management decisions.
WITHDRAWN: Study on multi-constraint and multi-objective optimization layout method of monitoring network for mine water inrush
Authors: Du Zhili , Wu Qiang , Zhao Yingwang , Zhang Xiaoyan , Yao Yi
Published: December 2022

Disastrous water inrush often causes heavy property losses and even casualties, while the current theory and technology of mine water prevention and control can not accurately predict the time and place of disastrous water inrush in mine, so monitoring disastrous water inrush has become an urgent problem to be solved. Through the networked deployment of water level sensors in the roadway, this paper proposes a monitoring network for catastrophic water inrush in coal mine, and studies a multi-constraint and multi-objective optimal deployment method for the monitoring network. By setting three practical constraints of mining area, risk level of water inrush and installation at specified location, and constructing two objective functions of minimum total cost and minimum average monitoring time, a mathematical model is established, and then NSGA - Ⅱ multi-objective genetic algorithm is designed to solve the model. As results, the method can optimize the monitoring network for mine water inrush from two dimensions of time and space. The proposed method is then verified in the Beiyangzhuang coal mine in the North China. The results show that the average time of the catastrophic water inrush monitored can be controlled within 916 seconds by using only 28 water level sensors, and the higher the risk level of water inrush, the shorter the monitoring response time. Due to the constraints of installation at specified location, the monitoring network can also take into account monitoring the daily water inflow in the Beiyangzhuang coal mine.
Diverse but Desolate Landscape of Gut Microbial Azoreductases: A Rationale for Idiopathic IBD Drug Response
Authors: Simpson Joshua B. , Sekela Josh J. , Carry Benjamin S. , Beaty Violet V. , Patel Shakshi , Redinbo Matthew R.
Published: December 2022

Background:
Prodrugs reliant on microbial activation are widely used but exhibit a range of efficacies that remain poorly understood. The anti-inflammatory compound 5-aminosalicylic acid (5-ASA), which is packaged in a variety of azo-linked prodrugs provided to most Ulcerative Colitis (UC) patients, show confounding inter-individual variabilities in response. Such prodrugs must be activated by azo-bond reduction to form 5-ASA, a process that has been attributed to both enzymatic and non-enzymatic catalysis. Gut microbial azoreductases (AzoRs) are the first catalysts shown to activate azo-linked drugs and to metabolize toxic azo-chemicals.
Results:
We chart the scope of the structural and functional diversity of AzoRs in health and in patients with the inflammatory bowel diseases (IBDs) UC and Crohn’s Disease (CD). Using structural metagenomics, we define the landscape of gut microbial AzoRs in 413 healthy donor and 1059 IBD patient fecal samples. Firmicutes encode a significantly higher number of unique AzoRs compared to other phyla. However, structural and biochemical analyses of distinct AzoRs from the human microbiome reveal significant differences between prevalent orthologs in the processing of toxic azo-dyes, and their generally poor activation of IBD prodrugs. Furthermore, while individuals with IBD show higher abundances of AzoR-encoding gut microbial taxa than healthy controls, the overall abundance of AzoR-encoding microbes is markedly low in both disease and health.
Conclusions:
Gut microbial AzoRs are functionally diverse but sparse in both health and disease, factors that may contribute to non-optimal processing of azo-linked prodrugs and idiopathic IBD drug responses.
Green Goals and Organic Produce: Towards the achievement of Sustainable Development Goals
Authors: Arora Manpreet
Published: December 2022

The current article is based upon bibliometric and secondary data where the author has contended to establish a connection of sustainable development and sustainable agricultural produce. The author believes that if organic practices in farming are adopted, they have the capacity to deal with multiple sustainable development goals including promoting the overall wellbeing of every living species. Present trends in the field of Organic Agriculture are seen to find out the themes where the acadecimicians are doing research.
Serum lipidomics reveals phosphatidylethanolamine and phosphatidylcholine disorders in patients with myocardial infarction and post-myocardial infarction-heart failure
Authors: Rong Jidong , He Tianmu , Zhang Jianyong , Bai Zhixun , Shi Bei
Published: December 2022

Background: Myocardial infarction (MI) and post-MI-heart failure (pMIHF) are major causes of death worldwide, however, the underlying mechanisms underlying pMIHF from MI are not well understood. The study sought to characterize early lipid biomarkers for the development of pMIHF disease.
Methods: Serum samples of 18 MI and 24 pMIHF patients were collected from the Affiliated Hospital of Zunyi Medical University and analyzed using lipidomics with Ultra High Performance Liquid Chromatography and Q-Exactive High Resolution Mass Spectrometer. All serum samples will be tested by the Official partial least squares discriminant analysis (OPLS-DA) to find the different expression of metabolites between the two groups. Furthermore, the metabolic biomarkers of pMIHF were screened using subject operating characteristic (ROC) curve and correlation analysis.
Results: The average age of 18 MI and 24 pMIHF participants is 57.83 ± 9.28 and 64.38 ± 10.89 years, respectively. The B-type natriuretic peptide (BNP) level was 328.5 ± 299.842 and 3535.96 ± 3025 pg/mL, TC was 5.59 ± 1.51 and 4.69 ± 1.13 mmol/L, and BUN was 5.24 ± 2.15 and 7.20 ± 3.49 mmol/L, respectively. In addition, 88 lipids, including 76 (86.36%) down-regulated lipids, were identified between the patients with MI and pMIHF. ROC analysis showed thatphosphatidylethanolamine (PE) (12:1e_22:0) (area under the curve [AUC] = 0.9306) and phosphatidylcholine (PC) (22:4_14:1) (AUC = 0.8380) were potential biomarkers. Correlation analysis showed that PE (12:1e_22:0) was inversely correlated with BNP and BUN, but positively correlated with TC. In contrast, the PC (22:4_14:1) was positively associated with both the BNP and the BUN, and was negatively associated with the TC.
Conclusions: Several lipid biomarkers were identified that could potentially be used to predict and diagnose patients with pMIHF. PE (12:1e_22:0) and PC (22:4_14:1) could sufficiently differentiate between patients with MI and pMIHF.