bluuebunny/crossref_metadata_2025 huggingface dataset:
ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression
Authors: Ye Guiwen , Li Jinteng , Yu Wenhui , Xie Zhongyu , Zheng Guan , Liu Wenjie , Wang Shan , Cao Qian , Lin Jiajie , Su Zepeng , Li Dateng , Che Yunshu , Fan Shuai , Wang Peng , Wu Yanfeng , Shen Huiyong
Published: August 2023

Improving health and delaying aging is the focus of medical research. Previous studies have shown that mesenchymal stem cell (MSC) senescence is closely related to organic aging and the development of aging-related diseases such as osteoarthritis (OA). m6A is a common RNA modification that plays an important role in regulating cell biological functions, and ALKBH5 is one of the key m6A demethylases. However, the role of m6A and ALKBH5 in MSC senescence is still unclear. Here, we found that the m6A level was enhanced and ALKBH5 expression was decreased in aging MSCs induced by multiple replications, H2O2 stimulation or UV irradiation. Downregulation of ALKBH5 expression facilitated MSC senescence by enhancing the stability of CYP1B1 mRNA and inducing mitochondrial dysfunction. In addition, IGF2BP1 was identified as the m6A reader restraining the degradation of m6A-modified CYP1B1 mRNA. Furthermore, Alkbh5 knockout in MSCs aggravated spontaneous OA in mice, and overexpression of Alkbh5 improved the efficacy of MSCs in OA. Overall, this study revealed a novel mechanism of m6A in MSC senescence and identified promising targets to protect against aging and OA.
SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways
Authors: Ren Xiaojuan , Feng Chao , Wang Yubo , Chen Pu , Wang Simeng , Wang Jianling , Cao Hongxin , Li Yujun , Ji Meiju , Hou Peng
Published: August 2023

Solute carrier family 39 member 10 (SLC39A10) belongs to a subfamily of zinc transporters and plays a key role in B-cell development. Previous studies have reported that its upregulation promotes breast cancer metastasis by enhancing the influx of zinc ions (Zn2+); however, its role in gastric cancer remains totally unclear. Here, we found that SLC39A10 expression was frequently increased in gastric adenocarcinomas and that SLC39A10 upregulation was strongly associated with poor patient outcomes; in addition, we identified SLC39A10 as a direct target of c-Myc. Functional studies showed that ectopic expression of SLC39A10 in gastric cancer cells dramatically enhanced the proliferation, colony formation, invasiveness abilities of these gastric cancer cells and tumorigenic potential in nude mice. Conversely, SLC39A10 knockdown inhibited gastric cancer cell proliferation and colony formation. Mechanistically, SLC39A10 exerted its carcinogenic effects by increasing Zn2+ availability and subsequently enhancing the enzyme activity of CK2 (casein kinase 2). As a result, the MAPK/ERK and PI3K/AKT pathways, two major downstream effectors of CK2, were activated, while c-Myc, a downstream target of these two pathways, formed a vicious feedback loop with SLC39A10 to drive the malignant progression of gastric cancer. Taken together, our data demonstrate that SLC39A10 is a functional oncogene in gastric cancer and suggest that targeting CK2 is an alternative therapeutic strategy for gastric cancer patients with high SLC39A10 expression.
Dysregulation of the Wnt/β-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder
Authors: Park Gaeun , Jang Wooyoung Eric , Kim Seoyeon , Gonzales Edson Luck , Ji Jungeun , Choi Seunghwan , Kim Yujin , Park Ji Hwan , Mohammad Hazara Begum , Bang Geul , Kang Minkyung , Kim Soobin , Jeon Se Jin , Kim Jin Young , Kim Kwang Pyo , Shin Chan Young , An Joon-Yong , Kim Min-Sik , Lee Yong-Seok
Published: August 2023

Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with impaired social behavior and communication, repetitive behaviors, and restricted interests. In addition to genetic factors, environmental factors such as prenatal drug exposure contribute to the development of ASD. However, how those prenatal factors induce behavioral deficits in the adult stage is not clear. To elucidate ASD pathogenesis at the molecular level, we performed a high-resolution mass spectrometry-based quantitative proteomic analysis on the prefrontal cortex (PFC) of mice exposed to valproic acid (VPA) in utero, a widely used animal model of ASD. Differentially expressed proteins (DEPs) in VPA-exposed mice showed significant overlap with ASD risk genes, including differentially expressed genes from the postmortem cortex of ASD patients. Functional annotations of the DEPs revealed significant enrichment in the Wnt/β-catenin signaling pathway, which is dysregulated by the upregulation of Rnf146 in VPA-exposed mice. Consistently, overexpressing Rnf146 in the PFC impaired social behaviors and altered the Wnt signaling pathway in adult mice. Furthermore, Rnf146-overexpressing PFC neurons showed increased excitatory synaptic transmission, which may underlie impaired social behavior. These results demonstrate that Rnf146 is critical for social behavior and that dysregulation of Rnf146 underlies social deficits in VPA-exposed mice.
Bellidifolin ameliorates isoprenaline-induced cardiac hypertrophy by the Nox4/ROS signalling pathway through inhibiting BRD4
Authors: Zhou Dingyan , Liu Weizhe , Zhang Juanjuan , Dong Yucui , Wu Jiangli , Zhang Yu , Dai Cheng , Zhang Tingting , Yang Gaoshan , Zhang Yue , Li Aiying
Published: August 2023

To date, there is no effective therapy for pathological cardiac hypertrophy, which can ultimately lead to heart failure. Bellidifolin (BEL) is an active xanthone component of Gentianella acuta (G. acuta) with a protective function for the heart. However, the role and mechanism of BEL action in cardiac hypertrophy remain unknown. In this study, the mouse model of cardiac hypertrophy was established by isoprenaline (ISO) induction with or without BEL treatment. The results showed that BEL alleviated cardiac dysfunction and pathological changes induced by ISO in the mice. The expression of cardiac hypertrophy marker genes, including ANP, BNP, and β-MHC, were inhibited by BEL both in mice and in H9C2 cells. Furthermore, BEL repressed the epigenetic regulator bromodomain-containing protein 4 (BRD4) to reduce the ISO-induced acetylation of H3K122 and phosphorylation of RNA Pol II. The Nox4/ROS/ADAM17 signalling pathway was also inhibited by BEL in a BRD4 dependent manner. Thus, BEL alleviated cardiac hypertrophy and cardiac dysfunction via the BRD4/Nox4/ROS axes during ISO-induced cardiac hypertrophy. These findings clarify the function and molecular mechanism of BEL action in the therapeutic intervention of cardiac hypertrophy.
Consanguinity and willingness to perform premarital genetic screening in Sudan
Authors: Elhadi Yasir Ahmed Mohammed , Alrawa Salma S. , Alfadul Esraa S. A. , Mahgoub Esra Abdallah Abdalwahed , El-Osta Austen , Belal Safaa Abdalazeem , Lucero-Prisno Don Eliseo , El Dabbah Noha Ahmed , Yahia Ashraf
Published: August 2023

Consanguineous marriage is prevalent in certain world regions due to cultural, economic, and social reasons. However, it can lead to negative consequences including an increased risk of genetic disorders in offspring. Premarital genetic screening (PMGS) is an important tool to identify and manage these risks before marriage. This study aimed to assess the magnitude of consanguineous marriage, knowledge of genetic diseases and PMGS, and attitudes and willingness to perform PMGS in Sudan. A national household survey was conducted using a multistage sampling technique, with a sample size of 2272 participants. Data were collected from December 2022 to March 2023 using an interviewer-administered questionnaire. A significant proportion of respondents (364/850, 42.8%) were married to consanguineal partners, with various types of relatedness. Moreover, 32.1% (242/755) of single respondents were planning to marry a close relative, signifying the likely persistence of consanguineous marriages in Sudan. The level of knowledge regarding genetic diseases and PMGS was relatively low in many states of Sudan, indicating the need for increased awareness interventions. A significant number of participants (85.2%) agreed that premarital screening is effective in reducing genetic diseases, whereas 71.2% supported the introduction of a mandatory PMGS program. Excluding married participants, 82.3% (1265/1537) of respondents were willing to perform PMGS, if implemented. These findings reflect the public positive attitude towards introducing the PMGS program and policies in Sudan and underscore the importance of addressing the knowledge gap of PMGS before such a potential implementation.
Dressed-state control of effective dipolar interaction between strongly-coupled solid-state spins
Authors: Lee Junghyun , Tatsuta Mamiko , Xu Andrew , Bauch Erik , Ku Mark J. H. , Walsworth Ronald L.
Published: August 2023

Strong interactions between defect spins in many-body solid-state quantum systems are a crucial resource for exploring non-classical states. However, they face the key challenge of controlling interactions between the defect spins, since they are spatially fixed inside the host lattice. In this work, we present a dressed state approach to control the effective dipolar coupling between solid-state spins and demonstrate this scheme experimentally using two strongly-coupled nitrogen vacancy (NV) centers in diamond. Through Ramsey spectroscopy on the sensor spin, we detect the change of the effective dipolar field generated by the control spin prepared in different dressed states. To observe the change of interaction dynamics, we deploy spin-lock-based polarization transfer measurements between the two NV spins in different dressed states. This scheme allows us to control the distribution of interaction strengths in strongly interacting spin systems, which can be a valuable tool for generating multi-spin correlated states for quantum-enhanced sensing.
A chromosome-level genome assembly of a deep-sea starfish (Zoroaster cf. ophiactis)
Authors: Liu Jun , Zhou Yang , Pu Yujin , Zhang Haibin
Published: August 2023

Understanding of adaptation and evolution of organisms in the deep sea requires more genomic resources. Zoroaster cf. ophiactis is a sea star in the family Zoroasteridae occurring exclusively in the deep sea. In this study, a chromosome-level genome assembly for Z. cf. ophiactis was generated by combining Nanopore long-read, Illumina short-read, and Hi-C sequencing data. The final assembly was 1,002.0 Mb in length, with a contig N50 of 376 Kb and a scaffold N50 of 40.4 Mb, and included 22 pseudo-chromosomes, covering 92.3% of the assembly. Completeness analysis evaluated with BUSCO revealed that 95.91% of the metazoan conserved genes were complete. Additionally, 39,426 protein-coding genes were annotated for this assembly. This chromosome-level genome assembly represents the first high-quality genome for the deep-sea Asteroidea, and will provide a valuable resource for future studies on evolution and adaptation of deep-sea echinoderms.
Effects of neutron radiation generated in deep space-like environments on food resources
Authors: Hatsuda Machiko , Kawasaki Hiroaki , Shigenaga Ayako , Taketani Atsushi , Takanashi Takaoki , Wakabayashi Yasuo , Otake Yoshie , Kamata Yayoi , Ichinose Akari , Nishioka Honoka , Kimura Hayato , Koganei Yumi , Komoriya Shiomi , Sakai Miyu , Hamano Yui , Yoshida Maria , Yamakura Fumiyuki
Published: August 2023

The impact of deep space cosmic rays on food resources is as important as the risks of cosmic rays to the human body. This study demonstrates the potential for neutrons as secondary radiation in deep space spacecraft to cause meat activation and oxidative modification of proteins and lipids. We conducted a series of experiments such as the neutron irradiation experiment, the radioactivation analysis and the biochemical analysis. Neutrons with energies from 1 to 5 MeV with doses from 0.01 Gy to 4 Gy were irradiated by the RIKEN accelerated-driven neutron source (RANS). Radioactive nuclei, 24Na, 42K, and 38Cl, were detected in the neutron-irradiated meat. The modification products of the proteins by oxidative nitration, 6-nitrotryptophan (6NO2Trp), and by a lipid peroxidation, 4-hydroxy-2-nonenal (4-HNE), were detected in several proteins with neutron dose dependent. The proteome analysis showed that many oxidative modifications were detected in actin and myosin which are major proteins of myofibrils. This study is of crucial importance not only as risk factors for human space exploration, but also as fundamental effects of radiation on the components of the human body.
Identification of RNF150 as the hub gene associated with microsatellite instability in gastric cancer
Authors: Pan Jun , Lan Qingzhi , Li Shengbao
Published: August 2023

Gastric cancer (GC) is a common digestive tract malignancy with the sixth global incidence and third cancer-related deaths, respectively. Microsatellite instability (MSI), accounting for one of the molecular subtypes of GC, plays an important role in GC and is affected by a sophisticated network of gene interactions. In this study, we aimed to explore the expression pattern and clinical performance of MSI related gene in GC patients. Weighted gene co-expression network analysis (WGCNA) was exploited to single out the vital module and core genes in TCGA database. We applied the protein–protein interaction (PPI) and survival analysis to propose and confirm RNF150 as the hub gene in GC. Finally, we utilized immunohistochemistry (IHC) and reverse transcription-polymerase chain reaction (RT-PCR) to explore the expression pattern of RNF150 in GC patients. With the highest weight correlation and standard correlation, RNF150 was selected as the hub gene for following validation. In validation, data obtained from the test sets showed a lower expression of RNF150 in MSI GC compared to microsatellite stability (MSS) GC. Moreover, survival analysis shows that MSI GC patients with a lower RNF150 expression level displayed the longer OS time. Compared to the expression in normal gastric tissues, the protein level of RNF150 was virtually up-regulated in ten cases of GC tissues. Furthermore, RNF150 protein level was decreased in MSI GC samples compared to MSS GC samples. When validated the mRNA expression with RT-PCR in fresh GC tissues, we also found the similar trend. RNF150 was identified as a novel MSI-related gene in GC. It is expected to be an auspicious prognostic biomarker for GC patients.
Bose glass and Fermi glass
Authors: Takahashi Korekiyo , Nakatsugawa Keiji , Sakoda Masahito , Nanao Yoshiko , Nobukane Hiroyoshi , Obuse Hideaki , Tanda Satoshi
Published: August 2023

It is known that two-dimensional superconducting materials undergo a quantum phase transition from a localized state to superconductivity. When the disordered samples are cooled, bosons (Cooper pairs) are generated from Fermi glass and reach superconductivity through Bose glass. However, there has been no universal expression representing the transition from Fermi glass to Bose glass. Here, we discovered an experimental renormalization group flow from Fermi glass to Bose glass in terms of simple $$\beta$$
β
-function analysis. To discuss the universality of this flow, we analyzed manifestly different systems, namely a Nd-based two-dimensional layered perovskite and an ultrathin Pb film. We find that all our experimental data for Fermi glass fall beautifully into the conventional self-consistent $$\beta$$
β
-function. Surprisingly, however, flows perpendicular to the conventional $$\beta$$
β
-function are observed in the weakly localized regime of both systems, where localization becomes even weaker. Consequently, we propose a universal transition from Bose glass to Fermi glass with the new two-dimensional critical sheet resistance close to $$R_\Box = h/e^{2}$$

R
□

=
h
/

e
2

.
The prevalence of chronic and episodic loneliness and social isolation from a longitudinal survey
Authors: Lim Michelle H. , Manera Karine E. , Owen Katherine B. , Phongsavan Philayrath , Smith Ben J.
Published: August 2023

Loneliness and social isolation, experienced more long-term, has been shown to increase mortality and lead to poorer health outcomes in specific cohorts. However, it is unclear what the prevalence of chronic loneliness and social isolation is, and which demographic groups are most at risk of reporting more chronic forms. A psychometrically validated classification system was used to identify people who met criteria for episodic and chronic loneliness and social isolation using the Household Income and Labour Dynamics in Australia (HILDA) survey waves 14–18. The prevalence of loneliness (overall 34%; 21% episodic, 13% chronic) far exceeded that of social isolation (overall 17%; 13% episodic, 4% chronic). There was consistency in the demographic characteristics (from age, sex, household type, income) of those who experienced loneliness and social isolation. However, people with a long-term health condition had an elevated risk of episodic loneliness (AOR 1.24, 95% CI 1.11–1.39) and a markedly higher risk of chronic loneliness (AOR 2.01, 95% CI 1.76–2.29), compared with those without a long-term health condition. Loneliness, both episodic and chronic subtypes, is more prevalent than social isolation. However, both chronic loneliness and social isolation remains neglected and poorly targeted within current practice and policy.
Comparison of infection and human immune responses of two SARS-CoV-2 strains in a humanized hACE2 NIKO mouse model
Authors: Yong Kylie Su Mei , Anderson Danielle E. , Zheng Adrian Kang Eng , Liu Min , Tan Sue Yee , Tan Wilson Wei Sheng , Chen Qingfeng , Wang Lin-Fa
Published: August 2023

The COVID-19 pandemic has sickened millions, cost lives and has devastated the global economy. Various animal models for experimental infection with SARS-CoV-2 have played a key role in many aspects of COVID-19 research. Here, we describe a humanized hACE2 (adenovirus expressing hACE2) NOD-SCID IL2Rγ−/− (NIKO) mouse model and compare infection with ancestral and mutant (SARS-CoV-2-∆382) strains of SARS-CoV-2. Immune cell infiltration, inflammation, lung damage and pro-inflammatory cytokines and chemokines was observed in humanized hACE2 NIKO mice. Humanized hACE2 NIKO mice infected with the ancestral and mutant SARS-CoV-2 strain had lung inflammation and production of pro-inflammatory cytokines and chemokines. This model can aid in examining the pathological basis of SARS-CoV-2 infection in a human immune environment and evaluation of therapeutic interventions.
DNA-PK inhibition extends the therapeutic effects of Top2 poisoning to non-proliferating cells, increasing activity at a cost
Authors: Wang Taixiang , Kyle Alastair H. , Baker Jennifer H. E. , Liu Nannan A. , Banáth Judit P. , Minchinton Andrew I.
Published: August 2023

Type II topoisomerase (Top2) poisoning therapy is used to treat a broad range of cancers via induction of double strand breaks (DSBs) in cells undergoing replication and transcription. Preventing the repair of DSBs via inhibition of DNA-PK, an inhibitor of non-homologous end-joining (NHEJ), increases cell kill with Top2 poisons and has led to the initiation of several clinical trials. To elucidate the cellular mechanisms leading to synergistic activity of dual DNA-PK/Top2 inhibition we looked at their effects in cycling versus non-cycling cells, in 3D spheroids and in xenograft models. Combined DNA-PK/Top2 inhibition was found to not only increase the cell kill in proliferating cells, the cell population that is typically most vulnerable to Top2 poisoning, but also in non-proliferative but transcriptionally active cells. This effect was observed in both cancer and normal tissue models, killing more cells than high concentrations of etoposide alone. The combination treatment delayed tumor growth in mice compared to Top2 poisoning alone, but also led to increased toxicity. These findings demonstrate sensitization of Top2β-expressing, non-cycling cells to Top2 poisoning by DNA-PK inhibition. Expansion of the target cell population of Top2 poison treatment to include non-proliferating cells via combination with DNA damage repair inhibitors has implications for efficacy and toxicity of these combinations, including for inhibitors of DNA-PK currently in clinical trial.
Disulfidptosis-associated LncRNAs index predicts prognosis and chemotherapy drugs sensitivity in cervical cancer
Authors: Liu Li , Liu Jun , Lyu Qianbao , Huang Jinzhi , Chen Yuanfeng , Feng Cuiyi , Liu Yaoyao , Chen Fukun , Wang Zhouyan
Published: August 2023

Disulfidptosis is a newly discovered form of cell death. Not yet clearly classified as programmed cell death or accidental cell death. This study aimed to create a novel disulfidptosis-related lncRNA index (DLI) that can be used to predict survival and chemotherapy drugs sensitivity in patients with cervical cancer. First of all, we found lncRNAs associated with disulfidptosis between cervical cancer tissues and normal tissues. By LASSO-Cox analysis, overlapping lncRNAs were then used to construct lncRNA index associated with disulfidptosis, which can be served to predict the prognosis of patients with CC, especially the chemotherapy drugs sensitivity. ROC curves and PCA based on DLI and clinical signatures were developed and demonstrated to have good predictive potential. In addition, differences in immune cell subset infiltration and differences in immune checkpoint expression between high-DLI and low-DLI groups were analyzed, and we investigated the relationship between the DLI and tumor mutation burden (TMB). In summary, we constructed a lncRNA prediction index associated with disulfidptosis. This has important clinical implications, including improving the predictive value of cervical cancer patients and providing a biomarker for cervical cancer guiding individualized treatment.
Magneto-optical induced supermode switching in quantum fluids of light
Authors: Furman Magdalena , Mirek Rafał , Król Mateusz , Pacuski Wojciech , Sigurðsson Helgi , Szczytko Jacek , Piętka Barbara
Published: August 2023

The insensitivity of photons towards external magnetic fields forms one of the hardest barriers against efficient magneto-optical control, aiming at modulating the polarization state of light. However, there is even scarcer evidence of magneto-optical effects that can spatially modulate light. Here, we demonstrate the latter by exploiting strongly coupled states of semimagnetic matter and light in planar semiconductor microcavities. We nonresonantly excite two spatially adjacent exciton-polariton condensates which, through inherent ballistic near field coupling mechanism, spontaneously synchronise into a dissipative quantum fluidic supermode of definite parity. Applying a magnetic field along the optical axis, we continuously adjust the light-matter composition of the condensate exciton-polaritons, inducing a supermode switch into a higher order mode of opposite parity. Our findings set the ground towards magnetic spatial modulation of nonlinear light.
Discovery and validation of metabolite markers in bloodstains for bloodstain age estimation
Authors: Lee Seungyeon , Lee You-Rim , Lee Jiyeong , Kang Hee-Gyoo
Published: August 2023

This study offers novel insights into the potential effectiveness of metabolites in bloodstains as forensic markers and provides the basis for the application of metabolomic approaches in forensic science.
Ratiometric fluorescent probes for pH mapping in cellular organelles
Authors: Munan Subrata , Yadav Rashmi , Pareek Niharika , Samanta Animesh
Published: August 2023

The present review presents the advances in ratiometric pH probes development for ΔpHi mapping in cellular organelles. Furthermore, we highlight the major challenges in developing ratiometric probes that merit further research in the future.
Symmetrical-waveform alternating current-promoted NiOxHy electrocatalysis for the oxygen evolution reaction
Authors: Qi Zhihao , Zhuang Jinwei , Yang Wantong , Yang Yonggang , Wang Ling , Cai Chenyang , Zhang Zhilin , Hua Yutao , Abdirazik Dilnur , Li Longhua , Shi Weidong , Hao Jinhui
Published: August 2023

The symmetrical-waveform alternating current activation enables the formation of a gradient oxygen vacancy in NiOxHy for a fast electrocatalytic oxygen evolution reaction.
Constructing single atom sites on bipyridine covalent organic frameworks for selective electrochemical production of H2O2
Authors: Huang Shaoda , Zhang Bingyan , Sun Huimin , Hu Hongyin , Wang Jinyan , Duan Fang , Zhu Han , Du Mingliang , Lu Shuanglong
Published: August 2023

Single atom sites anchored on bipyridine-rich COFs were constructed for the selective electrochemical production of H2O2via 2e− ORR.
White-emitting orthosilicate phosphor α-Sr2SiO4:Ce3+/Eu2+/K+: a bimodal temperature sensor with excellent optical thermometric sensitivity
Authors: Hui Bin , Zhao Kai , Si Han , Tong Xinlin , Wu Xinyi , Yin Li , Huang Saifang
Published: August 2023

We report Sr2SiO4:Ce3+/Eu2+/K+ as a bimodal optical temperature sensor with excellent thermometric sensitivity that can easily determine temperature by fluorescence intensity ratio (FIR) and chromaticity coordinate (CIE) techniques.
Hexagonal crystalline Magnus’ green salt analogues prepared from hydroxy-functionalised Pt and Pd complexes
Authors: Mian Mohammad Rasel , Afrin Unjila , Takaishi Shinya , Breedlove Brian K. , Yamashita Masahiro , Iguchi Hiroaki
Published: August 2023

New Magnus’ green salt (MGS) analogues with hydroxy-functionalised ligand were obtained as unprecedented hexagonal plate crystals. An unusual trigonal grade separation of chain complexes has been revealed by the structural analysis.
Cage-based sensors for circular dichroism analysis
Authors: Zhao Jianjian , Yang Chang-Yin , Hu Lianrui , Xu Lin , Dou Wei-Tao
Published: August 2023

Three-dimensional cages are promising platforms for chiral CD due to their stereochemical flexibility and cavity. In this minireview, we discuss recent advances, future challenges, and opportunities in the quantitative sensing of small molecules.
Recoverable solvent-free small molecular supramolecular pseudoeutectic adhesives with a wide temperature range
Authors: Li Mingyi , Xie Chenyang , Li Feng , Wang Xingzong , Wang Shiru , Qin Zhihui , Jiao Tifeng , Yang Jingyue
Published: August 2023

An innovative solvent-free pseudoeutectic adhesive with hydroxyl phosphonium salt as monomers with excellent recyclability and robust adhesion across a broad temperature range is reported.
High-performance flexible supercapacitors based on potassium nickel(ii) hexacyanoferrates(iii) nanoparticles on carbon cloth as an electrode material
Authors: Samyn L. M. , Lessa T. S. , Babu R. Suresh , Kalaivani A. , Barbosa T. M. , de Barros A. L. F.
Published: August 2023

Uniform PNHCF-NPs were prepared by co-precipitation way and coated on carbon cloth for high-performance supercapacitor applications. The hybrid showed highly flexible, improved specific capacitance, and good stability in Na+ and K+ ion electrolytes.
A SBA-15-templated mesoporous NiFe2O4/MXene nanocomposite for the alkaline hydrogen evolution reaction
Authors: Khalil Munawar , Lesa Michael , Juandito Alexander G. , Sanjaya Afiten R. , Ivandini Tribidasari A. , Kadja Grandprix T. M. , Mahyuddin Muhammad Haris , Sookhakian Mehran , Alias Yatimah
Published: August 2023

Synergistic electrocatalytic performance of SBA-15 templated mesoporous NiFe2O4/Mxene nanocomposite in alkaline hydrogen evolution reaction (HER).
Organic room temperature phosphorescence enhancement by grinding and adding water for humidity detection and anti-counterfeiting printing
Authors: Zhang Changli , Lou Lingyun , Li Yuzhan , Li Chengxiang , Wang Dong , Cao Hui , He Wanli , Yang Zhou
Published: August 2023

By virtue of the sensitive water response characteristics of a doped material, anti-counterfeiting printing and humidity detection based on this material have been demonstrated.
A multifunctional conductive nanocomposite hydrogel for high-performance strain sensors
Authors: Ren Jie , Zhang Minmin , Li Meng , Li Ruirui , Li Yan , Yang Wu
Published: August 2023

A tannic acid-coated graphitized carbon hydrogel possesses high tensile strength, self-adhesion, conductivity, and strain sensitivity. It adheres well to various surfaces and functions as a responsive strain sensor for human motion.
The kinetics of uncatalyzed and catalyzed urethane forming reactions of aliphatic diisocyanates with butan-1-ol
Authors: Juhász Anett , Serra Üneri Haymana , Lakatos Csilla , Vadkerti Bence , Rágyanszki Anita , Farkas Ödön , Kéki Sándor , Nagy Lajos
Published: August 2023

The kinetics of the urethane forming reactions of hexamethylene diisocyanate (HDI), 4,4′-dicyclohexyl-methane-diisocyanate (HMDI) and isophorone diisocyanate (IPDI) with butan-1-ol were studied by electrospray ionization mass spectrometry (ESI-MS).
Spodium, halogen and hydrogen bonds in the reactivity of bis(2,4-bis(trichloromethyl)-1,3,5-triazapentadienato)-Zn(ii)
Authors: Garazade Ismayil M. , Gurbanov Atash V. , Gomila Rosa M. , Frontera Antonio , Nunes Ana V. M. , Mahmudov Kamran T. , Pombeiro Armando J. L.
Published: August 2023

The reactivity of [Zn{NH = C(CCl3)NC(CCl3) = NH}2] towards acetone, pyrazole, 4,4′-bipyridine and Cu(acetylacetonate)2 is investigated and various noncovalent interactions are disclosed.
Spontaneous mesostructure formation produces optically transmissive Ni–P films that are catalytically active for the photoelectrochemical hydrogen evolution reaction
Authors: Ifkovits Zachary P. , Reed Jillian T. , Kempler Paul A. , Meier Madeline C. , Byrne Sean T. , Lin Shaoyang , Ye Alexandre Z. , Carim Azhar I. , Lewis Nathan S.
Published: August 2023

Ni–P films that are catalytically active for the hydrogen-evolution reaction were electrodeposited onto photoactive Si substrates between 20 °C and 80 °C.
Capillary detachment of a microparticle from a liquid–liquid interface
Authors: Rahat Sazzadul A. , Chaudhuri Krishnaroop , Pham Jonathan T.
Published: August 2023

Microparticles at a liquid–liquid interface are common in many material systems, from Pickering emulsions to capillary suspensions. Confocal and colloidal probe microscopy are combined to measure meniscus shape and detachment forces.
Progressing thin-film membrane designs for post-combustion CO2capture: performance or practicality?
Authors: Wu Ji , Hillman Febrian , Liang Can-Zeng , Jia Yuewen , Zhang Sui
Published: August 2023

Thin-film composite membranes demonstrate tremendous potential for energy-efficient CO2capture from power generation, but many technical hurdles are to be overcome before practical, better-performing and cost-effective designs could be realized.
Glucose oxidation assisted ammonia production via electrochemical dinitrogen reduction over CoWO4
Authors: Chaturvedi Akansha , Gupta Divyani , Kaur Sukhjot , Garg Kalpana , Nagaiah Tharamani C.
Published: August 2023

Schematic representation of replacement of anodic OER (left) with GOR (right) for ammonia production using CoWO4 as a bifunctional electrocatalyst.
A robust yet simple method to generate fluorescent amyloid nanofibers
Authors: Prajapati Kailash Prasad , Ansari Masihuzzaman , Yadav Deepak Kumar , Mittal Shikha , Anand Bibin Gnanadhason , Kar Karunakar
Published: August 2023

This work illustrates a new method for preparing fluorescent amyloid nanofibers. The strategic fabrication mentioned in the study is highly relevant to the advancement of both fundamental and applied research in biological and materials sciences.
Donor-modified multiple resonance emitters with accelerated reverse intersystem crossing towards high-efficiency and narrowband deep-blue OLEDs
Authors: Huang Xingyu , Xu Yulin , Miao Jingsheng , Jing Yan-Yun , Wang Shuni , Ye Zeyuan , Huang Zhongyan , Cao Xiaosong , Yang Chuluo
Published: August 2023

The strategic incorporation of pendant acridan units to the multiple resonance framework expedited the reverse intersystem crossing process, deriving a set of high-performance deep-blue emitters with external quantum efficiencies up to 28.7%.
The curious case of IDH mutant acute myeloid leukaemia: biochemistry and therapeutic approaches
Authors: Gruber Emily , Kats Lev M.
Published: August 2023

Of the many genetic alterations that occur in cancer, relatively few have proven to be suitable for the development of targeted therapies. Mutations in isocitrate dehydrogenase (IDH) 1 and -2 increase the capacity of cancer cells to produce a normally scarce metabolite, D-2-hydroxyglutarate (2-HG), by several orders of magnitude. The discovery of the unusual biochemistry of IDH mutations spurred a flurry of activity that revealed 2-HG as an ‘oncometabolite’ with pleiotropic effects in malignant cells and consequences for anti-tumour immunity. Over the next decade, we learned that 2-HG dysregulates a wide array of molecular pathways, among them a large family of dioxygenases that utilise the closely related metabolite α-ketoglutarate (α-KG) as an essential co-substrate. 2-HG not only contributes to malignant transformation, but some cancer cells become addicted to it and sensitive to inhibitors that block its synthesis. Moreover, high 2-HG levels and loss of wild-type IDH1 or IDH2 activity gives rise to synthetic lethal vulnerabilities. Herein, we review the biology of IDH mutations with a particular focus on acute myeloid leukaemia (AML), an aggressive disease where selective targeting of IDH-mutant cells is showing significant promise.
Green Supply Chain Practices: Toward A Sustainable Industry Development
Authors: Duarte Susana , do Rosário Cabrita Maria , Cruz-Machado V.
Published: August 2023

As environmental consciousness is growing, organizations are required to implement environmental-friendly practices, and to develop sustainable strategies not just for the health of the environment but also for sustaining the industry for the future. Today consumers value organizations that go green and are willing to pay a price premium for sustainable goods. Then, it is an incumbent need for the industry to integrate sustain ability concepts into its traditional supply chain management. The industry is a driving force behind sustainable development, where industry 4.0 is set to be a critical enabler. Nevertheless, to foster sustainable development of the industry, there is a need for applying uniform standards in environmental management to reduce the consumption of renewable resources and develop productive ways of reusing and recycling the used/waste resources. This paper, theoretical by nature, explores the impact of Green Supply Chain Practices (GSCP) on accelerating industry-related targets of Sustainable Development Goal (SDG) 9 on building resilient infrastructure, promoting inclusive and sustainable industrialization, and fostering innovation. Based on the literature review, conceptual interlinkages between the targets of SDG 9 and those SDGs that address issues of social, economic, and environmental goals, are studied in the context of GSCP. This work provides an understanding of the impact of green practices on the achievement of the SDGs.
Audit Committee Chair’s Geographic Distance and Earnings Quality
Authors: Niu Zhiqi , Lin Rongyu , Occeno Lilybelle
Published: August 2023

This paper empirically examines the relationship between the geographical distance of audit committee chairs(ACCs) and corporate earnings quality by taking A-share listed companies in Shanghai and Shenzhen from 2007 to 2018 as samples. It is found that the geographical distance between ACC’s work place and the operation place of listed companies can significantly reduce earnings quality, and the farther the geographical distance, the worse the earnings quality. In addition, the external audit conducted by the Big4 auditors can significantly suppress the impact of geographical distance on earnings quality. Further analysis found that there is a partial mediation effect in the quality of internal control. The research conclusions of this paper provide a new idea for for companies to appoint ACCs. The research on accounting and financial issues from the perspective of economic geography is refined to the field of audit committee, which enriches the research literature on factors influencing the functions of ACCs. It is of great significance to improve the performance of the committee, the long-term development of the company and the protection of investors’ interests.
Combining Big Data Analysis to Study the Relationship between the Tone of CSR Reports and Information Asymmetry
Authors: Zhang Mengwei , Zhang Yingyue , Che Wenxin , Yue Longfei
Published: August 2023

Big data mining and analytics help uncover hidden patterns and correlations in business. It serves as the optimal tool to interpret the behavior of companies in specific environments. Built on the large amount of data obtained from various sources, this paper examines the relationship between the tone of corporate social responsibility(CSR) reports and the degree of information asymmetry between investors and managers. Python software is used for data collection, text analysis, and word frequency statistics. The results show that the tone of the social responsibility report reduces the degree of information asymmetry, indicating that the tone of the social responsibility report has an incremental information effect. Further analysis shows that the tone of CSR reports significantly reduces information asymmetry in companies with optimistic forecasts and high media attention.
What Is the Impact of Digital Transformation? A Bibliometric Analysis
Authors: Li Yao , He Guowei , Wang Dan , Chen Yuze , Li Zhi
Published: August 2023

With the rapid development of digital technology, digital transformation has brought a great impact on many aspects of human society. Based on the existing research on the impact of digital transformation, which not only helps to understand the current research progress but also can provide effective suggestions for better implementation of digital transformation. This paper analyzes the existing research on the impact of digital transformation from the perspective of biometric. First, starting from statistical analysis, the basic distribution of studies in different countries/regions, different sources of publication, different years of publication, etc., are introduced. Then, the paper shows the collaboration of researchers from the analysis of relevant citation networks, cocitation networks and collaboration networks. In addition, a thematic analysis of the relevant studies is presented, in which the relevant co-occurrence networks are shown, and then a detailed analysis of the studies is presented. On the basis of these analyses, a discussion of future research is presented, and finally, conclusions are drawn. This study shows not only the basic picture of the impact of digital transformation but also future research trends that can provide meaningful research perspectives.
Techno-Economic Comparison of Solar and Geothermal Energy-based Systems: A Case Study in Western Sichuan
Authors: Lei Qing , Li Lei , Ni Ting
Published: August 2023

The application of renewable energy can effectively alleviate energy shortages and environmental pollution. However, electric heating and traditional combustion heating are still widely used in western Sichuan. This paper analyzes a techno-economic comparison between a solar-air energy heating system (System 1) and a geothermal-air energy heating system (System 2) designed for Litang. First, the distribution of renewable energy in Litang is analyzed. The system devices and operating modes of the two systems are described. According to the system design results, the paper compares the initial cost, operation cost, and net present value (NPV) of the two systems. The results show that both schemes are feasible from the perspective of technical analysis. While System 2 has lower initial investment, operation cost and higher NPV, which meets the actual needs of the project and local development planning. Using geothermal resources for urban central heating can achieve good energy saving and emission reduction benefits, and provide a reference for improving the proportion of local renewable energy use and optimizing the energy structure.
The Preventive Effect of Outdoor Recreational Fishing on Anxiety Disorder
Authors: Zhou Yanheng , Hu Zhineng
Published: August 2023

Background: Anxiety disorder, a severe global public health problem, has caused many adverse effects. Effectively preventing anxiety disorder is very important. This paper chose recreational fishing as an intervention measure to explore its effect on preventing anxiety disorder. Methods: The prevention effect of recreational fishing on anxiety disorder and the heterogeneity of this effect were analyzed through the ordinal logistic regression model. The robustness of the main results was tested through the multiple linear regression models. Results: “Fishing” significantly affected the anxiety level of residents. Compared with those who did not participate in outdoor recreational fishing, for those who participated there is a 3.494 decrease in the log odds of being in a higher severity of the anxiety level. With the increase in age, the negative effect of recreational fishing on anxiety levels was significantly lower. Conclusion: We focused on the preventive effect of outdoor recreational fishing on anxiety, contributing to add some evidence for non-medical measures to prevent anxiety disorder. Participation in outdoor recreational fishing has a significant prevention effect on anxiety disorder. Older people have less effect in preventing anxiety disorder by participating in fishing.
Perceived Discrimination Among Chinese International Students During the COVID-19 Pandemic: A Qualitative Study Based on Grounded Theory
Authors: Wu Min , Lou Jingxuan , Kung Lap Yan , Chen Xuanyuan , Shouse Roger C.
Published: August 2023

The reports on discrimination against the Chinese and Asian people has increased during the global COVID-19 pandemic. The study examined discrimination perceived by Chinese international students studying abroad during the COVID-19 pandemic, and constructed the theoretical conceptual model of perceived discrimination among Chinese international students based on the grounded theoretical analysis of the interview data. The study revealed the theoretical logic behind perceived discrimination among Chinese international students in the context of COVID-19 and offered some countermeasure suggestions.
Degradation prediction method of PEMFC based on deep learning hybrid model integrating ARIMA and LSTM
Authors: ZHANG Yufan , LI Yuren , MA Rui , ZHANG Hongyu , LIANG Bo
Published: August 2023

Fuel cell involves many disciplines such as electricity, mechanics, electrochemistry, and thermodynamics, and its performance degradation process is complex, involving multi-physics, multi-scale, multi-parts, and multi-factors. Thus, it is difficult for a single model to capture all kinds of characteristics of fuel cell simultaneously in degradation prediction. To ensure the prediction accuracy while better fitting the data linearly and nonlinearly, a prediction model of ARIMA combined with LSTM neural network is proposed in this study. The prediction results with residuals are used as features for LSTM prediction work after first predicting the voltage decay data by ARIMA and LSTM. Comparing the hybrid model with the single ARIMA model and the NAR model with support vector regression learning, it is found that the hybrid model performs better in terms of prediction accuracy and prediction performance.
Digital infrastructure construction drives green economic transformation: evidence from Chinese cities
Authors: Ma Ruiyang , Lin Boqiang
Published: August 2023

Existing studies mostly discussed the impact of transportation infrastructure on the economy and society. However, the environmental performance of digital infrastructure has been discussed less. This study explores the effect of digital infrastructure construction on green economic transformation based on theoretical analysis. Using the Broadband China policy as a quasi-natural experiment, the authors construct a staggered difference-in-difference (DID) model and empirically assess the effect of digital infrastructure on green economic development with panel data of Chinese 271 cities from 2003 to 2019. First, the main results indicate that digital infrastructure can enable green economic performance in Chinese cities. The results remain robust after considering the heterogeneous treatment effects, placebo test, and excluding the effect of other policies. Second, the heterogeneity results indicate that green economic performance in eastern and economically developed cities benefits more from digital infrastructure construction. Finally, by enhancing energy efficiency, fostering digital industrialization, and stimulating green technology innovation, the digital infrastructure indirectly contributes to the urban green economy development. This study put forward some constructive policy suggestions to promote green economic transformation from the digital infrastructure construction perspective.
Solve the linear quaternion-valued differential equations having multiple eigenvalues
Authors: Kou Kit Ian , Liu Wan-Kai , Xia Yong-Hui
Published: August 2023

The theory of two-dimensional linear quaternion-valued differential equations (QDEs) was recently established {see the work of Kou and Xia [Stud. Appl. Math. 141(1), 3–45 (2018)]}. They observed some profound differences between QDEs and ordinary differential equations. Also, an algorithm to evaluate the fundamental matrix by employing the eigenvalues and eigenvectors was presented in the work of Kou and Xia [Stud. Appl. Math. 141(1), 3–45 (2018)]. However, the fundamental matrix can be constructed providing that the eigenvalues are simple. If the linear system has multiple eigenvalues, how to construct the fundamental matrix? In particular, if the number of independent eigenvectors might be less than the dimension of the system, that is, the numbers of the eigenvectors are not enough to construct a fundamental matrix, how to find the “missing solutions”? The main purpose of this paper is to answer this question.
Unraveling optical degradation mechanism of β-Ga2O3 by Si4+ irradiation: A combined experimental and first-principles study
Authors: Huang Yuanting , Xu Xiaodong , Yang Jianqun , Yu Xueqiang , Wei Yadong , Ying Tao , Liu Zhongli , Jing Yuhang , Li Weiqi , Li Xingji
Published: August 2023

Wide bandgap β-Ga2O3 is an ideal candidate material with broad application prospects for power electronic components in the future. Aiming at the application requirements of β-Ga2O3 in space photoelectric devices, this work studies the influence of 40 MeV Si ion irradiation on the microstructure and optical properties of β-Ga2O3 epi-wafers. Raman spectroscopy analysis confirms that Si ion irradiation destroys the symmetric stretching mode of tetrahedral–octahedral chains in β-Ga2O3 epi-wafers, and the obtained experimental evidence of irradiation leads to the enhanced defect density of VO and VGa–VO from x-ray photoelectron spectroscopy. Combined with first-principles calculations, we conclude that most configurations of VO and VGa–VO are likely non-radiative, leading to quenching of experimental photoluminescence intensity. Unraveling optical degradation mechanism and predicting the optical application of β-Ga2O3 devices in the space environment by combining ground irradiation experiments with first-principles calculations still be one of the focuses of research in the future.