bluuebunny/crossref_metadata_2025 huggingface dataset:
Upregulation of circ_0000069 stimulates cervical cancer development by enhancing proliferation, migration, invasion while inhibiting apoptosis through the miR-4429/ZIC2 axis
Authors: Yang Hongjuan , Li Xiangkun , Zhao Xinwei , Wang Chang , Qin Dongyan , Gao Dongmei , Jiao Jinwen
Published: February 2020

Background Cervical cancer (CC) is a common female cancer according to global cancer statistics. The current study was used to investigate the regulatory mechanism of circ_0000069 in CC. Methods The real-time quantitative polymerase chain reaction (RT-qPCR) was used to assess circ_0000069, miR-4429, and zinc finger protein of the cerebellum 2 (ZIC2) expression in CC tissues and cells. Kaplan-Meier analysis was performed in CC patients to analyze the relationship between survival time and circ_0000069 expression. The proliferation, apoptosis, cell cycle of CC cells were detected by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-2H-tetrazol-3-ium bromide (MTT), colony formation, and flow cytometry analyses, respectively. In addition, western blot assay was employed to show expression levels of apoptosis/cell cycle-related proteins, as well as ZIC2. The migration and invasion of CC cells were assessed by transwell analysis. Possible target miRNAs of circ_0000069, along with the interaction between ZIC2 and miR-4429 were confirmed by pull-down and dual-luciferase reporter assays. Eventually, the functional role of circ_0000069 in vivo was clarified with the xenograft experiment in nude mice. Results Circ_0000069 was overexpressed in CC tissues and cells than controls. Furthermore, the silencing of circ_0000069 inhibited proliferation, migration, and invasion while included apoptosis and cell cycle arrest of CC cells, which was overturned by downregulation of miR-4429. Importantly, ZIC2 was a direct target of miR-4429 in CC cells, and we further confirmed that overexpression of miR-4429 suppressed CC progress by decreasing ZIC2 expression in CC cells. Surely, silencing of circ_0000069 inhibited tumorigenesis in vivo. Conclusion Our current results suggested that circ_0000069 exerted its tumorigenic roles by regulation of proliferation, apoptosis, cell cycle, migration, and invasion of CC cells, supporting that circ_0000069/miR-4429/ZIC2 axis may provide potential prognostic biomarkers for CC.
Ginsenoside Rb1 alleviates lipopolysaccharide-induced inflammatory injury by downregulating miR-222 in WI-38 cells
Authors: Wei Erhu , Fang Xiao , Jia Peisheng , Li Mingxia , Jin Peina , Li Fengyan , Wang Huaili , Gao Dan
Published: February 2020

Background Pneumonia is a serious respiratory tract infection disease in children, which threatens to the health or life of children patients. Ginsenoside Rb1 (Rb1) is a principle active ingredient extracted from the root of Panax notoginseng (Burk.) F.H.Chen with anti-inflammatory effect. Our study aimed to determine the effects and molecular mechanisms of Rb1 on lipopolysaccharide (LPS)-induced inflammatory injury of lung fibroblasts WI-38 cells. Methods Cell viability and apoptosis were evaluated by CCK-8 and flow cytometry analysis, respectively. The production of inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin (IL)-lβ, and IL-6 were measured by ELISA and RT-qPCR. miR-222 expression was examined by RT-qPCR. The expression levels of the nuclear factor-kappa B (NF-κB) p65 and phosphorylated p65 were detected by western blot. Results LPS stimulation induced WI-38 cell inflammatory injury by inhibiting cell viability, and inducing apoptosis and inflammatory cytokine production, while treatment with Rb1 significantly attenuated LPS-induced inflammatory injury in WI-38 cells. Additionally, Rb1 decreased LPS-induced upregulation of miR-222 and activation of the NF-κB pathway in WI-38 cells. Overexpression of miR-222 abolished the inhibitory effects of Rb1 on LPS-induced viability reduction, apoptosis, inflammatory cytokine production and activation of the NF-κB pathway. Conclusion Rb1 alleviated LPS-induced inflammatory injury in WI-38 cells via downregulating miR-222 and inactivation of the NF-κB pathway, contributing to our understanding of the effects and molecular mechanism of Rb1 in pneumonia.
Host DNA released by NETosis in neutrophils exposed to seasonal H1N1 and highly pathogenic H5N1 influenza viruses
Authors: Chan Louisa L.Y. , Nicholls John M. , Peiris J.S. Malik , Lau Yu Lung , Chan Michael C.W. , Chan Renee WY
Published: February 2020

Background Neutrophil (Nϕ) is of the most abundant number in human immune system. During acute influenza virus infection, Nϕs are already active in the early phase of inflammation-a time in which clinical biopsy or autopsy material is not readily available. However, the role of Nϕ in virus infection is not well understood. Here, we studied the role of Nϕ in host defense during influenza A virus infection, specifically assessing if it contributes to the differential pathogenesis in H5N1 disease. Methods Nϕs were freshly isolated from healthy volunteers and subjected to direct influenza H1N1 and H5N1 virus infection in vitro . The ability of the naïve Nϕs to infiltrate from the basolateral to the apical phase of the influenza virus infected alveolar epithelium was assessed. The viral replication, innate immune responses and Neutrophil extracellular trap (NET) formation of Nϕs upon influenza virus infection were evaluated. Results Our results demonstrated that influenza virus infected alveolar epithelium allowed more Nϕs transmigration. Significantly more Nϕs migrated across the H5N1 influenza virus infected the epithelium than the counterpart infected by the seasonal influenza H1N1 virus infected. Nϕs were equally susceptible to H5N1 and H1N1 virus infection with similar viral gene transcription. Productive replication was observed in H5N1 infected Nϕs. Both H5N1 and H1N1 infected Nϕs induced cytokines and chemokines including TNF-α, IFN-β, CXCL10, MIP-1α and IL-8. This inferred a more intense inflammatory response posed by H5N1 than H1N1 virus. Strikingly, NADPH oxidase-independent NET formation was observed in H1N1 infected Nϕs at 6 hpi while no NET formation was observed upon H5N1 infection. Conclusion Our data is the first to demonstrate that NET formation is abrogated in H5N1 influenza virus infection. Its contribution to the differential severity of H5N1 disease requires further investigation.
Influence of marital status on overall survival in adult chordoma patients: A SEER-based study
Authors: Tang Chao , Wang Ruiliang , Lu Qingguo , Wang Shantao , Jia Gen , Cao Pengfei , Nie Xinfa , Zhang Hailong
Published: February 2020

Background. As a rare primary bone tumor, no studies have reported the relationship between prognosis and marital status in patients with chordoma. Methods. We classified chordoma patients identified from the Surveillance, Epidemiology, and End Results (SEER) database from 1975 to 2016 into four groups: married, divorced/separated, widowed and single groups. Kaplan-Meier curves with log-rank test and Cox regression were used to analyse the effect of marital status on overall survival (OS). Results. A total of 1,080 patients were included in the study, 700 (64.8%) were married, 88 (8.1%) were divorced/separated, 78 (7.2%) were widowed and 214 (19.8%) were single. Among the four groups, the 5-year OS (45.2%), 10-year OS (12.5%) and median OS (56.0 months) were the lowest in the widowed group. After including age, sex, primary site, marital status, disease stage, tumor size, histological type, and treatment pattern, multivariate analysis showed that marital status was still an independent risk factor for chordoma patients, widowed patients have the lowest OS (hazard ratio [HR]: 1.71; 95% confidence interval [CI]: 1.25–2.33, p<0.001) compared with married patients. Similar results were observed after stratifying the primary site and disease stage. Conclusion. Marital status was an independent prognostic indicator for adult chordoma patients, and marital status was conducive to patient survival. Compared with married patients, widowed patients have a higher risk of death.
Development and validation of the Physical Activity-Specific Rumination Scale for Children (PARSC) through understanding the intrinsic facilitators and barriers of physical activity in UK children – a mixed-method study.
Authors: Ling Fiona Chun Man , Simmons Jonathan , Horton Mike
Published: February 2020

Background: An increasing number of physical activity (PA) interventions have been implemented to tackle child obesity epidemic, yet many have shown only moderate effectiveness. This is possibly due to a lack of in-depth understanding of the intrinsic motivators/demotivators to PA for children. Therefore, a main aim of this paper is to explore the intrinsic facilitators and barriers to PA participation through the lived experience of UK children (Study 1). The latter findings will facilitate the development of a psychometric instrument that assesses children’s tendencies to engage in repeated negative thoughts about PA (termed rumination ) which may hinder participation. Hence, our second aim is to develop and validate the PA-specific Rumination Scale for Children (PARSC) (Study 2). Methods: For Study 1, pedometry PA data were collected from 143 children (aged 6-10 years) over 3 weeks (Sample 1). Twenty-one focus groups were formed based on participants’ year group, sex and PA level. Focus group discussions were thematically analysed. For Study 2, the themes identified for the intrinsic barriers were used to develop PARSC. This was completed twice by 382 children (Sample 2), together with the PA subscale of the Physical Self-Description Questionnaire (short version). Sample 1 also completed the avoidant coping subscales of the Children Coping Strategies Checklist. Results: For Study 1, four overarching themes were identified for the intrinsic facilitators – sense of competence/accomplishments, cognitive motivator, sensations and socialisation/social facilitation. Four main themes for the intrinsic barriers were lack of competence, fear of negative experiences, external constraints and lacking a sense of purpose. For Study 2, results from Rasch analysis demonstrated that PARSC possessed sound internal validity and consistency, and test-retest reliability. Self-perceived PA and avoidant coping were predictive of PA-specific rumination tendencies (15% of variance explained), but objectively measured PA was not. Conclusions: The themes identified from the current study can potentially inform future PA interventions and PE curriculum for UK children. Also, PARSC can be a useful tool to assess children’s PA-specific rumination tendencies and to advance our understanding of the role of rumination in PA behaviour, but its applicability to other cultures warrants further investigations.
Veno-Arterial Extracorporeal Membrane Oxygenation for Electrical Injury Induced Cardiogenic Shock Support: A Case Report
Authors: Jamal Tamer , Shalabi Amjad , Grosman-Rimon Liza , Ghanim Diab , Amir Offer , Kachel Erez
Published: February 2020

BackgroundHigh voltage electrical injury (HVEI) of more than 1,000V is a potentially devastating form of a multisystem injury associated with high morbidity and mortality. We present the first case of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) as a life saving device for treating a patient with severe cardiogenic shock after a high voltage electrical injury.Case Presentation A 26-year-old male sustained HVEI while working with a concrete mixer pump that came in contact with a high voltage cable of 10,000 volts. He was immediately disconnected from the mixer pump, underwent cardiopulmonary resuscitation and transported to the nearest medical centre with severe cardiogenic shock with ejection fraction (EF) < 10%. Upon arrival he was in critical condition, sedated and mechanically ventilated, haemodynamically unstable and supported by intravenous (IV) inotropes after a few events of ventricular fibrillation, with an electrical entry point on the left hand and an exit point in his right leg. Blood pH was 6.8, PCO2 53 mmHg, PaO2 of 57 mmHg, lactate 8 mmol/L, and Troponin 38000 ng/dl. EF was 10% with a global severe left ventricular dysfunction. During cardiopulmonary resuscitation (CPR) including cardiac massage and few electrical shocks he was immediately connected to the VA-ECMO via open right femoral approach with distal arterial leg perfusion.He was treated with IV broad spectrum antibiotics, and high volume fluids to prevent rhabdomyolysis-induced acute kidney injury, total parenteral nutrition, topical silver sulfadiazine cream, and Granuflex for severe electrical burns. He was gradually weaned from inotropes over the next 3 days, during which his clinical condition and bloodwork improved tremendously. His EF gradually increased to 50% and he was weaned from the VA-ECMO and underwent decannulation 86 hours after initialization. He was discharged on day 27 without any sequelae.Conclusion VA-ECMO treatment can be a lifesaving device for treating severe cardiogenic shock caused by high voltage electrical injury, and should be considered while treating these “high-mortality risk” patients.
Cotton yield estimation model based on cloud computing
Authors: xu quan , Wang Chuanjian , Dai Jianguo , guo peng , Zhang Guoshun , Jiang Yan , Shi Hongwei
Published: February 2020

Timely and precise yield estimation is of great significance to agricultural management and macro-policy formulation. In order to improve the accuracy and applicability of cotton yield estimation model, this paper proposes a new method called SENP (Seedling Emergence and Number of Peaches) based on Amazon Web Services (AWS). Firstly, using the high-resolution visible light data obtained by the Unmanned Aerial Vehicle (UAV), the spatial position of each cotton seedling in the region was extracted by U-Net model of deep learning. Secondly, Sentinel-2 data were used in analyzing the correlation between the multi-temporal Normalized Difference Vegetation Index (NDVI) and the actual yield, so as to determine the weighting factor of NDVI in each period in the model. Subsequently, to determine the number of bolls, the growth state of cotton was graded. Finally, combined with cotton boll weight, boll opening rate and other information, the cotton yield in the experimental area was estimated by SENP model, and the precision was verified according to the measured data of yield. The experimental results reveal that the U-Net model can effectively extract the information of cotton seedlings from the background with high accuracy. And the precision rate, recall rate and F1 value reached 93.88%, 97.87% and 95.83% respectively. NDVI based on time series can accurately reflect the growth state of cotton, so as to obtain the predicted boll number of every cotton, which greatly improves the accuracy and universality of the yield estimation model. The determination coefficient (R2) of the yield estimation model reached 0.92, indicating that using SENP model for cotton yield estimation is an effective method. This study also proved that the potential and advantage of combining the AWS platform with SENP, due to its powerful cloud computing capacity, especially for deep learning, time-series crop monitoring and large scale yield estimation. This research can provide the reference information for cotton yield estimation and cloud computing platform application.
The relationship between personality dimensions, spirituality, coping strategies and clinical clerkship satisfaction among intern nursing students: A cross-sectional study
Authors: Rezapour-Mirsaleh Yasser , Aghabagheri Mahdi
Published: February 2020

Background The clinical clerkship is a crucial stage in nursing training and the dissatisfaction at this stage can lead to nursing quit in the future. This study aimed to evaluate the relationship among personality dimensions, spirituality, coping strategies and clinical clerkship satisfaction in intern nursing students. Methods This was a cross-sectional study. Considering any medical university in Iran as a single cluster, five medical universities, were initially selected. 65 nursing students were randomly selected from each university and from 325 distributed questionnaires, 293 were valid. All participants were provided with standard questionnaires regarding personality dimensions (NEO_FFI), spirituality, coping strategies (WoCQ), and satisfaction with clinical clerkship. Data analyzed using Pearson correlation and hierarchical multiple regression Results The results showed that spirituality, problem-focused coping and extraversion played an important role in predicting satisfaction with clinical clerkship among intern nursing students. Regression analysis represented that openness, extraversion, and spirituality could significantly predict problem-based coping style in intern nursing students. However, personality dimensions and spirituality were not good predictors for emotion-focused coping among intern nursing students. Conclusion Personality dimensions, coping strategies and spirituality, in particular, are good predictors of clinical clerkship satisfaction among intern nursing students.
Usefulness of virtual bronchoscopic navigation combined with radial endobronchial ultrasound for peripheral pulmonary lesions
Authors: xu chunhua , Wang Wei , Wang YuChao , Yuan Qi , Chi ChuanZhen , Zhang Qian , Li Li , Yang RuSong
Published: February 2020

Background: This study aimed to evaluate the diagnostic value of virtual bronchoscopic navigation combined with radial endobronchial ultrasound for peripheral pulmonary lesions (PPLs). Methods: The 105 patients with PPLs identified by computed tomography in Nanjing Brain Hospital underwent radial endobronchial ultrasound (R-EBUS) with or without virtual bronchoscopic navigation (VBN) randomly from January 2015 to December 2017. The diagnostic yield, operation time and complications were evaluated in the two groups. Results: There was no significant difference in the diagnostic yield between the VBN+R-EBUS group and the R-EBUS group (76.0% vs. 65.5%, P =0.287). The operation time in VBN+R-EBUS group was less than that in R-EBUS group (20.6±12.8 min vs. 28.6±14.3 min, P =0.016). No severe procedure related complications such as pneumothorax and hemoptysis were observed. Conclusions: VBN cannot improve the diagnostic yield, but it can shorten the operation time. The VBN combined with R-EBUS is a safe and effective technique for PPLs.
Determinants that Influence Women Entrepreneurs Performance in Ethiopia
Authors: Alene Endalew Terefe
Published: February 2020

The main objective of this study is to explore determinants that influence women entrepreneurs’ performance in medium and small enterprises in case of Gondar city in Ethiopia. The study employed a binary logistic regression model to identify determinants that influence women entrepreneurs’ performance. The binary logistic regression results show that educational level, working experience, access to finance, access to business training, government support, access to information, land ownership and reasonable levied tax are statistically significant predictors of performance in the study area. It is clear that in the context of Ethiopia, the determinants that influence women entrepreneurs’ performance could be aligned to these variables.
Sjogren’s Syndrome is associated with higher healthcare utilization after primary hip, but not primary knee arthroplasty: A U.S. cohort study
Authors: Singh Jasvinder A , Cleveland John D.
Published: February 2020

Objective: To assess whether Sjogren’s Syndrome (SS) is associated with outcomes after total knee or hip arthroplasty (TKA/THA).Methods: We used the 1998-2014 U.S. National Inpatient Sample data. We performed multivariable-adjusted logistic regression analyses to assess the association of SS with healthcare utilization (hospital charges, length of hospital stay, discharge to non-home setting), and in-hospital complications (implant infection, revision, transfusion, mortality), controlling for important covariates and confounders. In sensitivity analyses, we additionally adjusted the main models for hospital location/teaching status, bed size, and region.Results: We examined 4,116,485 primary THAs and 8,127,282 primary TKAs performed from 1998-2014; 12,772 (0.2%) primary TKAs and 6,222 (0.2%) primary THAs were done in people with SS. In multivariable-adjusted models, SS was associated with a statistically significant higher odds ratio (OR; 95% confidence interval (CI)) of discharge to a rehabilitation/inpatient facility post-THA, 1.13 (1.00, 1.28), but not post-TKA, 0.93 (0.86, 1.02). We noted no differences in the length of hospital stay or hospital charges. SS was associated with significantly higher adjusted odds of in-hospital transfusion post-THA, 1.37 (1.22, 1.55) and post-TKA, 1.21 (1.10, 1.34). No significant differences by SS diagnosis were seen in hospital stay, hospital charges implant infection, implant revision or mortality rates.Conclusions: People with SS had higher transfusion rate post-TKA/THA, and higher rate of discharge to non-home setting post-THA. The lack of association of SS with post-arthroplasty complications should reassure patients, surgeons and policy-makers about the utility of TKA/THA in people with SS undergoing these procedures.
Intention to stop khat chewing and associated factors among khat chewers in Gondar city, northwest Ethiopia: using Trans Theoretical Model
Authors: Adugna Asmamaw , Azale Telake , Handebo Simegnew
Published: February 2020

Background Khat chewing practice is rapidly increasing worldwide and currently an estimated over 10 million people chew khat. Trans Theoretical Model (TTM) is a promising model to assess the of stages of behavior change is a combination of intention. Given a sufficient control over the behavior, people carry out their intentions when the enabling environments arises. Assessing intention to quit chewing khat, motivational factors that influence behavior, is important to design effective interventions. Methods Community-based cross-sectional study was conducted from March to April 2019 in Gondar city, northwest Ethiopia. Six hundred five khat chewers were selected from six kebeles using cluster sampling method. Structured interviewer-administered questionnaire was used to collect data. Bivariate and multi-variable logistic regression model were fitted. Adjusted Odds ratio (AOR) with 95% confidence interval and p-values <0.05 in the multi-variable model were used to declare significant association. Results Out of the total participants, 69.3% (95% CI: 65.8-72.9) had intention to stop khat chewing within six months from the day of interview or before. Majority of the study participants 55.4% were on contemplation stage. Higher self-reevaluation [AOR=2.8, (95%CI: 1.6-5.0)], environmental reevaluation [AOR=1.9, (95%CI: 1.1-3.3)] and social liberation [AOR=1.8, (95% CI: 1.0-3.1)] process of changes were associated with intention to quit khat chewing. In addition, using additional substances and start chewing at earlier age were associated with lower intention to quit chewing. Conclusion Majority of the khat chewers had the intention to stop khat chewing. Increased self-reevaluation, environmental reevaluation and social liberation process of changes enhance the intention of quitting khat chewing. Thus, stage-based interventions should be done to motivate Khat chewers to stop khat chewing.
Valutare l’apprendimento precoce di una seconda lingua: rilevanza degli studi longitudinali
Authors: Lopriore Lucilla
Published: February 2020

L’apprendimento precoce delle lingue straniere – in particolare nella scuola primaria – è un processo affascinante ma complesso, fortemente condizionato dall’età degli allievi, dal contesto, dagli obiettivi specifici del ciclo scolastico e dalla didattica proposta. La fascia d’età è di fatto una delle variabili che più incide sullo sviluppo e sul sostegno delle competenze linguistiche, e richiede da parte dei docenti l’adattamento degli approcci adottati, delle attività proposte e dei materiali utilizzati per rispondere allo sviluppo cognitivo e emotivo degli allievi. Valutare i risultati dell’apprendimento in uno scenario di questo tipo è un processo delicato che deve essere monitorato con strumenti idonei che consentano di utilizzare la valutazione sia per comprenderne il valore aggiunto sia per sostenere l’apprendimento nel tempo. Questo contributo introduce le implicazioni dei risultati di alcuni studi longitudinali che hanno monitorato e valutato lo sviluppo delle competenze degli allievi e offerto spunti di riflessione sui processi di apprendimento.
DOWÓD NAUKOWY W POSTĘPOWANIU KARNYM
Authors: Szczepaniec Maria
Published: February 2020

W artykule zaprezentowane zostały rozważania dotyczące dowodu naukowego ze szczególnym uwzględnieniem problematyki związanej z oceną takiego dowodu. Podjęta została kwestia możliwości stworzenia reguł mogących stanowić pomocne wskazówki w procesie dokonywania oceny wartości dowodowej opinii biegłego. Analizie poddano także możliwość wskazania biegłemu przez organ procesowy konkretnej metody badawczej, którą w danym przypadku powinien zastosować.
Sławomir Kursa, Testator i formy testamentu w rzymskim prawie justyniańskim, wyd. Wolters Kluwer Polska, Warszawa 2017, ISBN: 978-83-8107-366-0, ss. 352
Authors: Loska Elżbieta
Published: February 2020

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PRZYGOTOWANIE DO PRZESTĘPSTWA PRANIA PIENIęDZY
Authors: Suchowierski Bartłomiej
Published: February 2020

Unijny Komitet Moneyval w ramach raportu skierowanego wobec Polski, oceniając kryminalizację prania pieniędzy w Polsce, nie uwzględnił różnic panujących między systemem prawa kontynentalnego a systemem common law oraz instytucji części ogólnej polskiego k.k. Wynikiem tego był negatywny raport zarzucający brak kryminalizacji przygotowania do prania pieniędzy. W odpowiedzi na ten raport, ustawodawca pomimo krytyki płynącej ze strony Sądu Najwyższego i Biura Analiz Sejmowych spenalizował formę stadialną przygotowania do prania pieniędzy, uzasadniając to wyłącznie raportem Moneyval.W artykule odtworzono międzynarodowy standard przeciwdziałania praniu pieniędzy oraz wykazano, że Polski system prawny w pełni jemu odpowiada. Dowiedziono, że zarzuty Moneyval były niesłusznie, gdyż: po pierwsze komitet ten nieprawidłowo odtworzył standard międzynarodowy, a po drugie faza wstępna prania pieniędzy była w większości przypadków karalna w Polsce jeszcze przed penalizacją formy stadialnej przygotowania. Dowiedziono także, że kraje nie są związane raportami Moneyval. W opracowaniu wyrażono pogląd uzasadniający tezę, że polski system przeciwdziałania praniu pieniędzy mógł stracić na sile wskutek penalizacji formy stadialnej przygotowania do prania pieniędzy.
SŁOWA Z MOWY METELLUSA NUMIDICUSA, KTÓRĄ WYGŁOSIŁ W CZASIE CENZURY DO LUDU, KIEDY ZACHĘCAŁ DO OŻENKU; ORAZ DLACZEGO TĘ MOWĘ GANIONO I JAK – PRZECIWNIE – BYŁA BRONIONA - AULUS GELLIUS, „NOCE ATTYCKIE” 1,6 TEKST - TŁUMACZENIE - KOMENTARZ
Authors: Tarwacka Anna
Published: February 2020

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Konaklama İşletmelerinde Rekabet Avantajı Kaynakları: Bodrum Örneği
Authors: Yıldırım Yıldırım , Çakırlı Hakan
Published: February 2020

Bu çalışmada temel olarak konaklama işletmelerinin rekabet avantajı kaynakları ele alınmaktadır. Bu doğrultuda araştırmacının temel amacı konaklama işletmelerinin rekabet içinde avantaj sağladığı kaynakları belirlemektir. Bu çalışma için örnek olarak Bodrum/Muğla destinasyonu seçilmiştir. Araştırmanın amacı kapsamında nitel veriler, yarı yapılandırılmış görüşme tekniği ile toplanmıştır. Bodrum’da faaliyet gösteren 5 yıldızlı konaklama işletmelerinden gönüllülük esasına dayalı olarak rastsal şekilde 16 konaklama işletmesi seçilmiştir. Bu 16 konaklama işletmesinin yöneticileri ile görüşülerek veriler toplanmıştır. Elde edilen verilerin işlenmesinde içerik analizi tekniği kullanılmıştır. Araştırmanın bulguları doğrultusunda konaklama işletmeleri arasında yoğun bir rekabetin yaşandığı, işletmelerin birbirleri ile yarışırken hizmet kalitelerini arttırmaya özen göstererek sadık müşteri kitlelerini oluşturmaya çalıştıkları sonucuna varılmıştır. Ayrıca çalışmanın sonuçlarında işletmelerin kaliteli hizmet vermek adına işletme bünyesinde çalışan personelin kalifiye olmasına, fiyat-kalite dengesini sağlamaya, tedarikçileri ile iyi ikili ilişkiler kurmaya, müşteri geri bildirimlerini dikkatli şekilde takip etmeye özen gösterdikleri görülmüştür.
Photocatalytic Degradation and Antibacterial Study of Copper(II) Mustard Thiourea Complex
Authors: Sukhadia Vandana , Sharma Rashmi , Meena Asha
Published: February 2020

Aims:

The aim of this research work is to synthesise, study and analyse
photocatalytic degradation, kinetics.

Background:

Copper(II) mustard thio urea complex has been synthesized and
characterized through FT-IR, NMR, ESR studies.

Objective:

Photocatalytic degradation of copper(II) mustard thio urea complex was studied
in the presence of ZnO as a catalyst in the solution form, using a non polar solvent benzene
and a polar solvent methanol with different compositions. Antibacterial activities of
copper(II) complex have also been studied against Staphylococcus aureus.

Method:

O.D. was measured after different time intervals spectrophotometrically to
measure the degradation of the complex.

Result:

Plot of 2+ log O.D. (absorbance) versus time was plotted and found to be linear.
The heterogeneous photocatalysis followed pseudo-first-order reaction kinetics. The present
study suggests that the CMT complex shows antibacterial activity at different concentrations.

Conclusion:

The rate of photocatalytic degradation of CMT complex was studied and analyzed.
It has been found that the rate of degradation varies with different parameters like
the concentration of complex, the amount of catalyst, light intensity, solvent polarity etc.
The CMT complex derived from natural mustard oil has shown an inhibitory effect on the
growth of S. aureus which may cause skin diseases.
DEVELOPMENT OF INTERACTIVE LEARNING MEDIA LECTORA INSPIRE ON BASIC BANKING SUBJECT TO IMPROVE STUDENT’S LEARNING INTEREST
Authors: Apriniya Pratiwi , Aisyah Mimin Nur
Published: February 2020

This research aimed to develop interactive learning media with Lectora Inspire for the students of grade X AKL SMK Negeri 1 Tempel on Basic Banking subjects with the competence of saving. The research used the Research Development with ADDIE (analysis, design, development, implementation, evaluation) model. The media was assessed by material expert, media expert, and teacher. The results show that the feasibility of interactive learning media by material expert in strongly feasible category (average score of 4, 26), by media experts in strongly feasible category (average score of 4, 36), by teacher in strongly feasible (average score of 4, 33), and by students in feasible category (average score of 4, 07). The interactive learning media developed is strongly feasible to be used as learning media for students. The student’s learning interest before and after the use of interactive learning media has increased by 8% from 64% to 72%. Paired sample t-test obtained tcount  -5.213 with sig 0.000 showed significant learning interest’s improvement. Therefore, it can be concluded that interactive learning media is able to improve student’s learning interest. Keywords: Interactive Learning Media, Lectora Inspire, Student’s Learning Interest.
IMPLEMENTASI GAMIFIKASI BERBANTU MEDIA KAHOOT UNTUK MENINGKATKAN AKTIVITAS BELAJAR, MOTIVASI BELAJAR, DAN HASIL BELAJAR JURNAL PENYESUAIAN SISWA KELAS X AKUNTANSI 3 DI SMK KOPERASI YOGYAKARTA TAHUN AJARAN 2018/2019
Authors: Wardana Serly , Sagoro Endra Murti
Published: February 2020

Penelitian ini bertujuan untuk (1) meningkatkan Aktivitas Belajar Siswa Kelas X Akuntansi 3 di SMK Koperasi Yogyakarta melalui penerapan Gamifikasi Berbantu Media Kahoot; (2) meningkatkan Motivasi Belajar Siswa Kelas X Akuntansi 3 di SMK Koperasi Yogyakarta melalui penerapan Gamifikasi Berbantu Media Kahoot; (3) meningkatkan Hasil Belajar Jurnal Penyesuaian Siswa Kelas X Akuntansi 3 di SMK Koperasi Yogyakarta melalui penerapan Gamifikasi Berbantu Media Kahoot. Penelitian ini merupakan Penelitian Tindakan Kelas (PTK) yang dilakukan sebanyak 2 siklus yang terdiri dari perencanaan, pelaksanaan tindakan, observasi dan refleksi. Hasil penelitian ini menunjukkan peningkatan Aktivitas Belajar sebesar 14,31%, dapat dilihat dari kenaikan persentase rata-rata dari 64,68% menjadi 78,99%. Peningkatan Motivasi Belajar sebesar 9,22%, dapat dilihat dari kenaikan persentase rata-rata dari 69,88% menjadi 79,10%. Peningkatan Hasil Belajar sebesar 27,13, dapat dilihat dari kenaikan nilai rata-rata pra penelitian dan post-test siklus II, dan persentase ketuntasan belajar dari 12,50% menjadi 82,61% yang berarti mengalami peningkatan sebesar 70,11%.Kata kunci: Gamifikasi, Kahoot, Aktivitas Belajar, Motivasi Belajar, Hasil Belajar
THE EFFECT OF CAREER EXPECTATION, CAREER GUIDANCE, AND WORK MOTIVATION TOWARD WORK READINESS STUDENT
Authors: Sofiani Gifaninda , Taman Abdullah
Published: February 2020

This research aims to determine: 1) The effect of Career Expectation toward Work Readiness student, 2) The effect of Career toward Work Readiness student, 3) The effect of Work toward Work Readiness student, 4) The effect of Career Expectation, Career Guidance, and Work Motivation simultaneoulsy toward Work Readiness student. This research is an Ex-post facto study with a quantitative approach, conducted at SMK Negeri 1 Bantul with the subject of student of XII Accounting Grader. The data collection technique used was a questionnaire. Before analyzing the data, a prerequisite test for analysis must be carried out, namely normality test, linearity test, and multicollinearity test. The data analysis technique used in this study is simple regression analysis and multiple regression analysis. The results of this study are: 1) There is a positive and significant influence between Career Expectation and Work Readiness with a value of r2x1y 0.153. 2) There is a positive and significant influence between Career Guidance and Work Readiness with a value of r2x2y 0.205. 3) There is a positive and significant influence between Work Motivation and Work Readiness toward Work Readiness student with r2x3y 0.124. 4) There is a positive and significant influence between Career Expectation, Career Guidance, and Work Motivation simultaneoulsy toward Work Readiness student with a value of R2(1,2,3) 0,283. So Career Guidance is a variable with the greatest influence among the three independent variables with r2x2y  0.205 so student can be more active in doing Career Guidance that supports Student toward Work Readiness. Keywords: Work Readiness, Career Expectation, Career Guidance, Work Motivation
The Diabetes and Emotional Health Handbook and Toolkit for Health Professionals Supporting Adults With Type 1 and Type 2 Diabetes: Formative Evaluation
Authors: Halliday Jennifer A , Speight Jane , Bennet Andrea , Beeney Linda J , Hendrieckx Christel
Published: February 2020

Background

Health professionals have expressed unmet needs, including lacking the skills, confidence, training, and resources needed to properly attend to the psychological needs of people with diabetes.

Objective

Informed by needs assessments, this study aimed to develop practical, evidence-based resources to support health professionals to address the emotional needs of adults with type 1 or type 2 diabetes.

Methods

We developed a new handbook and toolkit informed by formative evaluation, including literature reviews, stakeholder consultation and review, and a qualitative study. In the qualitative study, health professionals participated in interviews after reading sections of the handbook and toolkit.

Results

The literature review uncovered that psychological problems are common among adults with diabetes, but health professionals lack resources to provide related support. We planned and drafted resources to fill this unmet need, guided by stakeholder consultation and an Expert Reference Group (ERG). Before finalizing the resources, we implemented feedback received from stakeholders (ERG, health professionals, academics, and people with diabetes). The resulting resources were the practical, evidence-based Diabetes and Emotional Health handbook and toolkit. A total of 19 health professionals took part in the qualitative study about the handbook and toolkit. They viewed the resources favorably, felt empowered to support people with diabetes experiencing psychological problems, and felt motivated to share the resources with others. Some gave examples of how they had used the handbook in clinical practice. A perceived highlight was the inclusion of a process model outlining 7 steps for identifying and supporting people with emotional problems: the 7 A’s model. With funding from the National Diabetes Services Scheme (NDSS), more than 2400 copies of Diabetes and Emotional Health have been distributed. It is freely available on the Web. The NDSS is an initiative of the Australian Government administered with the assistance of Diabetes Australia.

Conclusions

The new evidence-based resources are perceived by stakeholders as effective aids to assist health professionals in providing emotional support to adults with diabetes. The 7 A’s model may have clinical utility for routine monitoring of other psychological and health-related problems, as part of person-centered clinical care.
Using Remote Medical Care Services to Prevent the Spread of COVID-19 (Preprint)
Authors: Liao Yanhui , Shugart Yin Yao , Chen Wei , Tang Jinsong
Published: February 2020

UNSTRUCTURED

Abstract is not available.
Data mining analysis of miR-638 and key genes interaction in cisplatin resistant triple-negative breast cancer
Authors: Hermawan Adam , Putri Herwandhani
Published: February 2020

Cisplatn is one of the chemotherapy for the treatment of triple‐negatve breast cancer (TNBC), but its eﬀectveness is limited because of the phenomenon of chemoresistance. miR‐638 was shown to regulate chemoresistance; however, it has never been validated in the cisplatn‐resistant tumor from patents. This present study aimed to identfy the key gene regulatory networks of miR‐638 and evaluate the potental role of the miR‐638 and its targets as potental prognosis biomarkers for cisplatn‐resistance triple‐negatve breast cancer patents. The miR‐638 target was obtained from the miRecords database while the mRNA of chemoresistance biomarker candidate was obtained from the GSE18864 of GEO database, which is mRNA of cisplatn‐resistance TNBC patents. CCND1 and FZD7 are potental candidates for cisplatn chemoresistance biomarkers in patents with TNBC. Moreover, a Kaplan‐Meier survival plot showed that breast cancer patents with low mRNA levels of FZD7 had signifcantly worse overall survival than those in higher mRNA expression group. Taken together, miR‐638 plays a role in cisplatn resistance mechanism through a mechanism involving its target gene CCND1 and FZD7. Overall, miR‐638, CCND1, and FZD7 are candidates for cisplatn biomarker resistance in TNBC.
Avaliação comparativa de técnicas para o ensino de geografia: uma abordagem a partir do conceito de ciclo hidrológico
Authors: Da Silva Fredson Pereira , Cavalcanti Lucas Costa de Souza
Published: February 2020

RESUMO O ciclo hidrológico descreve a existência e o movimento da água sobre, dentro e acima da Terra. O objetivo desse trabalho foi comparar técnicas de ensino que podem ser utilizadas pelos docentes nas suas aulas para facilitar a aprendizagem dos alunos em relação ao ciclo hidrológico. O presente trabalho foi desenvolvido na Escola Estadual NM 11, em uma turma de 34 alunos do 6º ano do Ensino Fundamental. Seguindo a proposta do Cone da Aprendizagem, testou-se a hipótese de que jogos são mais eficientes para a aprendizagem do que vídeos. Dessa maneira confirmou-se que jogos podem ser uma alternativa mais eficaz do que vídeos para se trabalhar em sala de aula assuntos complexos como o ciclo da água. Palavras-chave: Educação Geográfica; Recursos didáticos; Ciclo hidrológico. ABSTRACTThe water cycle describes the existence and movement of water on, in and above the Earth. The objective of this work was to compare teaching techniques that can be used by teachers in their classes to facilitate students' learning in relation to the hydrological cycle. The present work was developed in the State School NM 11, in a class of 34 students of the 6th year of Elementary School. Following the proposal of The Cone of Learning, we tested the hypothesis that games are more efficient for learning than videos. Thus, it has been confirmed that games can be a more effective alternative than videos to work complex subjects in the classroom, such as the water cycle.Keywords: Geographic Education; Educational resources; Water cycle. RESUMEN El ciclo hidrológico describe la existencia y el movimiento del agua sobre, dentro y por encima de la Tierra. El objetivo de este trabajo fue comparar técnicas de enseñanza que pueden ser utilizadas por los docentes en sus aulas para facilitar el aprendizaje de los alumnos en relación al ciclo hidrológico. El presente trabajo fue desarrollado en la Escuela Estadual NM 11, en una clase de 34 alumnos del 6º año de la Educación Inicial. Siguiendo la propuesta del Cono del Aprendizaje, se buscó probar la hipótesis de que los juegos son más eficientes para el aprendizaje que los videos. De esta manera se ha confirmado que los juegos pueden ser una alternativa más eficaz que los videos para trabajar en el aula temas complejos como el ciclo del agua.Palabras-clave: Educación Geográfica; Recursos didácticos; Ciclo hidrológico.    DOI: http://dx.doi.org/10.22169/revint.v14i33.1526
A inclusão no ensino superior a partir da perspectiva do sujeito
Authors: Silva Aline Gomes da , Jung Hildegard Susana , Silva Louise de Quadros da
Published: February 2020

RESUMO Este artigo versa sobre o tema da inclusão no ensino superior. Seu objetivo consiste em suscitar um debate referente à autonomia e acessibilidade de estudantes inclusivos de uma universidade da região metropolitana de Porto Alegre, a partir da perspectiva do educando.  Para tal, realizamos um estudo de caso, de cunho qualitativo, apoiado em uma revisão de literatura. Além disso aplicamos um questionário a estudantes com deficiência da instituição pesquisada. Os resultados desta revisão apontam para: a) a importância do acompanhamento do aluno incluso; b) os materiais e recursos devem ser adaptados às necessidades de cada estudante; c) a educação inclusiva deve preparar o educando para o mercado de trabalho. Como considerações finais, indicamos que a educação inclusiva é aquela que promove o desenvolvimento pleno do estudante e não possibilita apenas o convívio social. Palavras-chave: Educação inclusiva; Ensino superior; Formação do estudante com deficiência.   ABSTRACT This article deals with the topic of inclusion in higher education. Its objective is to raise a debate regarding the autonomy and accessibility of inclusive students of a university in the metropolitan region of Porto Alegre, from the perspective of the student. For that purpose, we conducted a qualitative case study, supported by a literature review. In addition, we applied a questionnaire to students with disabilities of the researched institution. The results of this review point to: a) the importance of accompanying the student; b) the materials and resources must be adapted to the needs of each student; c) inclusive education should prepare the student for the job market. As final considerations, we indicate that inclusive education is one that promotes the full development of the student and not only enables social interaction. Keywords: Inclusive education; Higher education; Training of students with disabilities.   RESUMEN Este artículo versa sobre el tema de la inclusión en la enseñanza superior. Su objetivo consiste en suscitar un debate referente a la autonomía y accesibilidad de estudiantes con discapacidades de una universidad de la región metropolitana de Porto Alegre, a partir de la perspectiva del estudiante.  Para ello, realizamos un estudio de caso, de tipo cualitativo, apoyado en una revisión de literatura. Además, aplicamos un cuestionario a estudiantes con discapacidades de la institución investigada. Los resultados de esta revisión señalan a: a) la importancia del acompañamiento del alumno inclusivo; b) los materiales y recursos se deben adaptar a las necesidades de cada estudiante; c) la educación inclusiva debe preparar al estudiante para el mercado laboral. Concluimos que la educación inclusiva es aquella que promueve el pleno desarrollo del estudiante y no posibilita solo el convivo social. Palabras-clave: Educación inclusiva; Enseñanza superior; Formación del estudiante con discapacidades.DOI: http://dx.doi.org/10.22169/revint.v14i33.1574
Educação Ambiental
Authors: Alencastro Mario Sergio Cunha , De Oliveira Marcia Maria Fernandes
Published: February 2020

DOI: http://dx.doi.org/10.22169/revint.v14i33.1747
Топометрия воксела: фрактальные и евклидовы дескрипторы диффузионно-взвешенной формы разнонаправленного магнитно-резонансного сигнала
Authors: Posnansky O.P.
Published: February 2020

Форма поверхности внутри вокселей в разнонаправленной диффузионно-взвешенной магнитно-резонансной томографии характеризуется топологической неоднородностью. Если контур неправильной формы можно идентифицировать и сегментировать из цифрового изображения, то соответствующие геометрические дескрипторы могут применяться для его числовой характеристики. В работе введены фрактальные и евклидовы размерности объема, площади и среднего радиуса для описания поверхности. Их можно использовать в качестве суррогатного параметра для определения шероховатости. Взаимосвязь между показателями разных вокселей показывает существование отдельных групп со структурными различиями, заданными типом биологической ткани. Метод представляет стандартизированную непрерывную числовую классификацию формы, полезную для количественного анализа изменения морфологии поверхности от воспалительных заболеваний, процессов старения и развития биологических тканей.
Что нам стоит завод построить
Authors: Яминский И.В.
Published: February 2020

В современном цифровом производстве успешным станет тот, кто построит высокотехнологичный завод, который будет выпускать много полезного. Наш рассказ о системах точного трехкоординатного позиционирования, которые востребованы во многих системах: фрезерных обрабатывающих центрах, микромашининге, лазерной резке и гравировке, сканирующих зондовых микроскопах и молекулярных 3D-принтерах.
Фемтоскан и Фемтоскан XI на форуме "Открытые инновации"
Authors: Яминский И.В. , Ахметова А.И.
Published: February 2020

С 21 по 23 октября в Сколково в очередной раз прошел VIII Международный форум "Открытые инновации". Тема форума в этом году – "Цифровая нация. Трансфер к интеллектуальной экономике". Центр перспективных технологий принял участие в мероприятии в качестве экспонента, а ведущие сотрудники компании выступили с докладами.
Микросистемы преобразования акустического давления
Authors: Генералов С.С. , Амеличев В.В. , Годовицын И.В. , Поломошнов С.А. , Никифоров С.В. , Григорьев Д.М. , Ильков А.В.
Published: February 2020

Представлены результаты разработки и исследований преобразователей акустического давления (ПАД) емкостного типа. Представлены основные технические характеристики емкостных ПАД и мембранных модулей.
Formación inicial de maestros en promoción de la lectura y la literatura en España desde la perspectiva del profesorado universitario
Authors: Álvarez-Álvarez Carmen , Pascual-Díez Julián
Published: February 2020

Este artículo analiza la situación actual de la formación inicial de los futuros docentes para desarrollar la promoción lectora y literaria en la escuela primaria. Han participado 73 profesores responsables de la didáctica de la lectura y la literatura de diversas universidades españolas. Se constatan carencias en la formación lectora-literaria en los planes de estudios de magisterio, así como condicionantes positivos y negativos de la formación lectora del alumnado universitario. Se concluye con propuestas de trabajo para hacer que la didáctica de la lectura y la literatura en el aula universitaria sea más formativa, atractiva e intensa.
Dewan Redaksi
Authors: Partisipatoris Jurnal
Published: February 2020

Jurnal Partisipatoris