bluuebunny/crossref_metadata_2025 huggingface dataset:
Fatores associados ao desenvolvimento de audição e linguagem em crianças submetidas a implante coclear na região Norte
Authors: Freire Ana Luiza Lopes de Freitas , Koury Gisele Vieira Hennemann , Yamaguchi Cíntia Tizue , Gomes Cecília Leite , Anjos Karlla Lorenna dos Santos , Farias Diego Costa
Published: February 2022

Objetivo: Investigar os fatores relacionados ao desenvolvimento de audição e linguagem em crianças submetidas a cirurgia de Implante Coclear (IC) em um hospital universitário na região Norte do Brasil. Métodos: Estudo descritivo, transversal e retrospectivo de 48 pacientes submetidos ao IC, de 0 a 84 meses, entre 2010 e 2020. Foram descritos o estrato socioeconômico familiar, escolaridade dos pais, realização do teste da orelhinha, idade de entrada no serviço de IC, idade de implantação, acesso a fonoterapia pós IC e categorias de audição e linguagem alcançadas. Resultados: Pacientes submetidos ao teste da orelhinha (40%) foram atendidos pela primeira vez no serviço de IC com idade menor e realizaram o procedimento em idade mais precoce. Crianças que tiveram acesso à fonoterapia pós IC apresentaram categorias de linguagem e audição superiores. A maior escolaridade dos pais se correlacionou com categorias de linguagem e audição melhores. Observou-se correlação significativa entre a idade de realização do IC, o estrato socioeconômico e a escolaridade dos pais. Conclusão: A identificação precoce da perda auditiva e a implantação no período crítico proporcionam melhores resultados auditivos e de linguagem.
Incentivo paterno na prática do aleitamento materno
Authors: Silva Suzana Lins da , Caminha Maria de Fátima Costa , Santos Camila Carvalho dos , Cruz Matheus Lauriano da Silva , Corrêa Thais de Albuquerque , Freitas Déborah Lemos , Rocha Rayanne Victória Araújo Lins , Lima Elisama da Paz Oliveira , Barreto Luciana da Silva , Batista Filho Malaquias
Published: February 2022

Objetivo: Identificar a frequência do incentivo paterno para a prática do Aleitamento Materno (AM). Métodos: Estudo transversal, recorte do inquérito “Saúde, nutrição e serviços assistenciais numa população carente do Recife”, com coleta de dados no período de julho a outubro/2015. A população do estudo atual foi representada pelas mães das 310 crianças de zero a três anos usuárias das duas Unidades Básicas de Saúde existentes na comunidade estudada. Selecionadas as variáveis de interesse e elaborado banco “ad hoc”. Os dados foram analisados no programa Stata 12.1. O inquérito foi aprovado pelo Comitê de Ética em Pesquisa Abordando Seres Humanos (CEP). Resultados: Pouco mais da metade das mães (57,7%) recebeu incentivo do pai da criança ao AM. A maioria (92,9%) havia realizado pré-natal, porém 93,9% não receberam orientação sobre AM. Metade (55,1%) recebeu visita domiciliar na primeira semana de vida. Prevaleceu a faixa etária entre 20 a 35 anos (72,4%). Pouco mais da metade (64,0%) possuía abaixo de 12 anos de estudo e a maioria (72,6%) pertencia a classe social C. Conclusão: Os dados deste estudo apontam para o reconhecimento do pai como importante influenciador no processo de AM, pois pode ser um aliado e estimulador dessa prática.
Adipose tissue in homeostasis
Authors: Пальцын А.А. , Свиридкина Н.Б. , Аракелов С.Э.
Published: February 2022

Сегодня биология клеток жировой ткани - адипоцитов - «передний край» метаболомики с глобальной социальной значимостью. Нарушение жирового обмена - самая распространенная патология современного человечества. Уже много лет преимущественным проявлением данного нарушения является избыточное содержание жира в теле, неудобное, затрудняющее движения и осложняющееся многими болезнями. С течением лет эта губительная тенденция нарастает. Жир - приспособление эволюции для обеспечения энергией физической и интеллектуальной работы, абсолютно необходимое для такой работы, сделался главным патогенным фактором наиболее распространенных незаразных болезней. В статье рассматриваются некоторые механизмы этого явления и возможные способы противодействия ему. Можно надеяться, что обнаруженная медицинскими исследованиями последних лет высокая пластичность жировой ткани (как оказалось, управляемая) будет способствовать успеху этого направления (решения проблемы ожирения).

Today, biology of adipose tissue cells, adipocytes, is the “forward line” of metabolomics and has a global social significance. Disordered fat metabolism is the most common pathology of modern mankind. For many years the predominant manifestation of this disorder has been excessive content of fat in the body, which is uncomfortable, movement-hampering, and complicated by many diseases. Over the years, this destructive trend has been growing. Fat is a critically important, evolutionarily adaptive source of energy for physical and intellectual activities. However, it become a major pathogenic factor of most common noninfectious diseases. The article discusses some mechanisms of this phenomenon and possible countermeasures. Hopefully, the high plasticity of adipose tissue (that has been found controllable) discovered by recent studies will contribute to success of this endeavor.
Approximation and comparison of the empirical liquidity cost function for various futures contracts
Authors: Dyshaev M. , Izergin D. , Fedorov V.
Published: February 2022

The article is dedicated to the study and comparison of the empirical liquidity cost function for various futures contract. The function is determined by the current state of the limit order book (LOB). Comparing the liquidity cost of futures contracts, we suggest the use of the initial margin instead of the number of lots or asset units. The form of the empirical liquidity cost function is obtained and a number of approximations for practical use are proposed. The approximations were achieved by quadratic, linear and power functions. The explanation of the difference in the distribution of the values of the liquidity cost function depending on the required initial margin is proposed. These results can be used for optimal execution of large orders, including portfolio hedging.
Compactness theorems connected with problems with unknown boundary
Authors: Подгаев А.Г.
Published: February 2022

Доказывается часть результатов, относящихся к исследованию задач с неизвестной границей методами компактности, которые были представлены на IX Международной конференции по математическому моделированию, посвященной 75-летию В. Н. Врагова. Дано обоснование теоремы об относительной компактности, которую можно применять при исследовании задач типа задачи Стефана с неизвестной частью границы, а также в задачах для уравнений переменного типа с неизвестной границей смены типа. Приведен пример такой задачи и показано, что полученные оценки на приближенные решения уравнения и функции, описывающие последовательность границ, приближающуюся к искомой границе фазового перехода, полностью совпадают с условиями, сформулированными в основной теореме о компактности.Автору не известны теоремы подобного типа. Теорема является новым видом теорем компактности, приспособленным к задачам типа Стефана.Для лучшего восприятия приведены наиболее простые условия при которых справедлив результат, совпадающие с условиями рассмотренного примера. Однако результат может быть обобщен на значительно более общие ситуации, такие как число границ фазового перехода и замену оценки второй производной оценкой более сложного агрегата, встречающегося в уравнениях с вырождениями на решениях.
Complex coacervation and compartmentalized conversion of prebiotically relevant metabolites
Authors: Smokers Iris B. A. , van Haren Merlijn H. I. , Lu Tiemei , Spruijt Evan
Published: February 2022

Metabolism and compartmentalization are two of life’s most central elements. Constructing synthetic assemblies based on prebiotically relevant molecules that combine these elements can provide insight into the requirements for the formation of life-like protocells from abiotic building blocks. In this work, we show that a wide variety of small anionic metabolites have strong enough interactions with oligoarginine (R10) to form coacervate protocells through liquid-liquid phase separation. The stability of the coacervates can be rationalized by the molecular structure of the metabolites, and we show that three negative charges for carboxylates or two negative charges complemented with an unsaturated functional group for phosphates and sulfates is sufficient for phase separation. We show that these metabolites remain reactive in compartmentalized systems. Protometabolic reactions that lead to an increased interaction with the oligopeptide can be exploited to induce the formation of coacervate protocells. The resulting coacervates can localize other metabolites and enhance their conversion. Finally, reactions of compartmentalized metabolites can also alter the physicochemical properties of the coacervates and ultimately lead to protocell dissolution if the reaction products decrease the coacervate stability. These results reveal the intricate interplay between (proto)metabolic reactions and coacervate compartments, and show that coacervates are excellent candidates for metabolically active protocells.
On the binding energy of atoms in crystals and the speed of sound
Authors: Dall'Osso Aldo
Published: February 2022

The speed of sound depends on the structure and on the material properties of the crystal, such as the density and the Young’s modulus. On the other hand, from atomistic arguments it is possible to link the Young’s modulus to other material properties. These observations drive to a relation between the binding energy of the atoms in a crystal (which is one of the parameters appearing in the Mie-Lennard-Jones potential), the speed of sound in the longitudinal direction and the mass of one atom in the lattice. Applications of this relation to noble gases and few metals are presented and the results compared to others taken from literature.
Investigating sex differences in genetic relatedness in great-tailed grackles in Tempe, Arizona to infer potential sex biases in dispersal
Authors: Sevchik August , Logan Corina , McCune Kelsey , Blackwell Aaron , Rowney Carolyn , Lukas Dieter
Published: February 2022

In most bird species, females disperse prior to their first breeding attempt, while males remain close to the place they hatched. While explanations for such female bias in natal dispersal have focused on the resource-defense based monogamous mating system that is prevalent in most birds, the factors shaping dispersal decisions are often more complex. Studying species with different social and mating systems can help illuminate the various factors shaping sex biased dispersal. Here, we use genetic approaches to determine whether females and/or males disperse in great-tailed grackles (Quiscalus mexicanus), which have a mating system where the males hold breeding territories that multiple females might choose to place their nest in, but females forage independently of these breeding territories across a wider area. We find that for individuals caught at a single site in Arizona, (i) the average relatedness among all female dyads, but not of males, is higher than average relatedness among other individuals at the site; (ii) that female close relatives are found within shorter distances from each other than pairs of unrelated females, but male close relatives at larger distances than pairs of unrelated males; and (iii) we find a decline in relatedness with increasing spatial distances for females, but not for males. Our findings show that great-tailed grackles offer opportunities to understand how divergent social and mating systems might shape natal philopatry and dispersal, given their reversal of the usual sex-bias in dispersal with females associating with genetic relatives while males are not.
Prosocial decision making in an operant box paradigm promotes visual communication and complex behavioral sequences in adolescent rat dyads
Authors: Charron Valérie , Talbot Joey , Plamondon Hélène
Published: February 2022

The adolescence period is marked by intense social play behavior in rats, shown to influence social, cognitive, and emotional processes. The goal of this study was to assess the ability of adolescent rats to display prosocial behaviors through a sharing task and to learn prosociality from vicarious observation. The paradigm involved a pretraining phase, using a two-chamber operant box with two reward differentiated levers on the actor side, providing one and two sucrose pellets respectively upon pressing. Dyads where actors were not exposed to pretraining session acted as controls. The prosocial phase ensued, where an easy lever pressed dispensed one pellet while a hard lever pressed dispensed one reward to both the actor and observer in the adjacent chamber. Actor and observer rats then switched roles enabling vicarious learning assessment. Findings revealed pretraining to be critical for behavior and task contingency in adolescent rats. Complex behavioral sequences marked by increased visual communication between dyads was observed. Despite the diversity of behaviors, observer rats failed to learn prosocial behaviors. This study shows pretraining to act as a key element promoting behavioral interactions; the thorough behavioral analysis performed highlights the ability for adolescent rats to display a richness of behaviors when paired with a congener. Another interesting finding was the ability for rats to learn prosocial behaviors, but the inability to learn such behaviors by observation. These findings call for further studies to understand prosocial behaviors in rodents and their ability to learn such behaviors from a congener.
Aplikasi Sistem Manufaktur Berbasis Web pada Industri Kecil Logam Pembuat Komponen
Authors: Cucu Wahyudin
Published: February 2022

Pada saat ini cara berkomunikasi industri kecil menengah (IKM) dengan konsumen, umumnya masih bersifat face to face, artinya jika konsumen ingin mengetahui informasi perusahaan dan produk yang dihasilkan perusahaan secara lebih lengkap, konsumen harus mengunjungi perusahaan, atau dari pihak perusahaan melakukan pengenalan terhadap konsumen dengan cara presentasi. Hal ini mengakibatkan konsumen mengalami kesulitan memantau pesanan, memerlukan waktu yang lama untuk menentukan suatu keputusan jika konsumen ingin melakukan pemesanan produk kepada IKM.

Penelitian ini berusaha merancang suatu website bagi IKM, sehingga diharapkan akan memudahkan konsumen untuk memesan produk dengan cepat, memudahkan dalam memantau pesanannya serta memudahkan perusahaan untuk mengenalkan produk- produk yang diproduksinya.
The Effect of Chrom Element on Oxidation Behaviour of TiAl-based Alloy
Authors: Pawawoi
Published: February 2022

Tial-based alloy have long been considered to be suitable candidates for high temperature structural application expecially at below 700oC. Unfortunately, in higher temperature (between 700oC and 900oC), TiAl-based alloy have a poor oxidation resistance. The reason for this is that the alloys generally form rapidly growing titania based surface oxide scales rather than protective alumina layers.Various efforts have been and are being made to overcome these problems. One of alloying elements have been developed is chrom element which hoped could decreased the form of titania and lead to form alumina layers.
Pengaruh Proses Temper terhadap Sifat Mekanik dan Struktur Mikro pada Baja Perkakas Eskylos 2344
Authors: Pawawoi
Published: February 2022

Baja perkakas pengerjaan panas (Hot Work Tool Steel) Eskylos 2344 merupakan baja perkakas yang dihasilkan dari proses ESR (Electro Slag Remelting). Baja ini memiliki sifat tahan gesekan, tahan tekanan tinggi, mampu keras (good hardenability) dan memiliki ketahanan panas (hot resistant) yang baik. Dengan adanya sifat mampu keras yang baik ini, maka sifat baja perkakas Eskylos dapat diubah dengan proses perlakuan panas (heat treatment). Salah satu proses perlakuan panas yang dapat dilakukan untuk memperbaiki sifat mekaniknya adalah pemanasan pada temperatur Austenisasi yang diikuti dengan pendinginan cepat kemudian dilanjutkan proses temper. Hasil optimun perlakuan panas baja perkakas pengerjaan panas Eskylos 2344 dicapai pada temperatur Austenisasi 1050oC dan proses temper pada temperatur 400oC dengan kekerasan rata-rata 55,6 Hrc dan ketahanan aus 5,24%. Sedangkan struktur mikro baja perkakas pengerjaan panas Eskylos 2344 menunjukkan sebaran partikel-partikel karbida spheroidal halus dalam matrik martensit temper.
The Relationship between English Language Proficiency and Logical Thinking Skills
Authors: Tedjo Ester Widawati
Published: February 2022

The present study investigates the relationship between students’ English language proficiency and their logical reasoning reflected by their performance in applying spreadsheet program. Since logical thinking is the basis of both using English language for communication and operating Microsoft Excel program, students can very likely show similar success in their performance while learning these two skills. The subjects were 67 students enrolled at a secretarial college in Surabaya, Indonesia. Data were collected from the students scores of TOEIC international test and Computer II course focusing on Microsoft Excel. Means of the scores were calculated and the sets of data were analyzed to see if there was a significant correlation between them. The results showed that the students’ English proficiency correlated significantly with their academic performance in computer. It can then be concluded that students with better logical thinking ability seem to be more successful in learning English as a foreign language.
ON THE METHODOLOGY OF FILM ANALYSIS
Authors: Kozhokaru Tatiana I.
Published: February 2022

The article provides an overview of the analytical tools used in cinema studies. The paper identifies the main problems of film analysis as well as classifies and describes the various approaches to it. The systematization of a wide range of available methodological tools may be considered as propaedeutics of film analysis – it gives a fairly complete picture of the variety of existing methods, allowing researchers either to choose the approach that turns out to be optimal for a particular study or, problematizing the present tools, to offer a new methodology.
Factores que cuantifican la percepción de calidad en el servicio al cliente en un restaurante mexicano
Authors: Becerra-Godínez† Juan Alexis , Serralde-Coloapa José Leonardo , Ramírez-Arellano Aldo , Acosta-Gonzaga Elizabeth
Published: February 2022

Una de las industrias más destacadas de la economía mexicana es la restaurantera. Su importancia, debido a su número de empresas, creación de empleos y emprendimientos, ha ocasionado que se genere un alto índice de competitividad. Esto provoca que se busquen estrategias para mejorar la calidad del servicio que ofrecen, con el propósito de retener y atraer clientes. El objetivo de este trabajo fue identificar los factores que conforman la percepción de la calidad en el servicio en un restaurante mexicano. Para ello, se utilizó el instrumento DINESERV, mediante un enfoque cuantitativo y un análisis factorial confirmatorio. Los resultados mostraron que el instrumento DINESERV es válido para restaurantes mexicanos. Asimismo, se detectaron los factores que integran el servicio al cliente, enfatizando los aspectos de tangibilidad, confiabilidad, respuesta y empatía. Características como personal competente y con experiencia, tener siempre presente los intereses del cliente y la apariencia de la vestimenta y limpieza del personal de servicio son elementos clave para que el restaurante genere mayor satisfacción en sus clientes.
HUMAN RESOURCES EMPOWERMENT IN GLOBAL COMPETITION
Authors: Sumaryono Roy
Published: February 2022

Increasing employee productivity is important role in achieving of company effectiveness. Job satisfaction is important because it will improve performance and have an effect on increasing employee and company productivity. This study uses quantitative methods and data analysis using path analysis. The population used is the truck mixer driver PT. Merak Jaya Beton Karang Pilang Plant Surabaya as many as 42 people and the respondents used were all mixer truck drivers. The results showed that workload had a significant effect on work productivity, the total effect value = 0.337 and self-leadership had no significant effect on work productivity, the total effect value = 0.279
Design of Smart Farm Irrigation Monitoring System Using IoT and LoRA
Authors: Irianto Kurniawan D.
Published: February 2022

Agriculture is an essential part of society in Indonesia because most of the population lives off of farming. Water and irrigation are the most critical and central factors in the agricultural system. The uneven distribution of irrigation water can be a problem for farmers. In addition, most of the current irrigation systems are still operated manually, for example, irrigation gates. The gate still works manually and requires human labor to run it. This study aims to design a smart farm irrigation system using internet of things and LoRa communication technology. LoRa can transmit information up to a range of several kilometers without an internet connection. It will be advantageous when the farm's location is deep in the forest, and there is no GSM signal for internet access. This study indicates that this system brings benefits for farmers in running agriculture. Farmers' work time is shorter. They can use the remaining time to do other businesses to increase their income. The irrigation monitoring process becomes easier because they do not need to come to the farm location. In fact, they can use smartphones to monitor it.
GLOBAL SURVIVAL BASED ON CLINICAL, HISTOLOGICAL, AND BIOLOGICAL TUMOR CRITERIA IN A SECONDARY PUBLIC BRAZILIAN HOSPITAL
Authors: Mosquéra Júlia Milhomem , Alves Amanda Ribeiro , Cavalli Gianna Carolina Pereira , Ramos Larissa Feitosa de Albuquerque Lima , Vasconcelos Flávio Lúcio
Published: February 2022

Objective: To analyze the overall survival of women with breast cancer based on clinical, histological, and biological tumor data in a secondary hospital in Federal District/Brazil. Method: Retrospective cohort study of women diagnosed with breast cancer from 2012 to 2019, followed up until December 2020, having its data analyzed in 2021. The population studied was from the area covered of the Regional Hospital of Santa Maria (Brasília/Distrito Federal/Brazil), a secondary service, linked to the Brazilian Unified Health System. The information analyzed in this study were state at the last visit (life or dead), the presence of clinically compromised axillary lymph nodes, staging by the TNM system, location of distant metastasis (bone or visceral), histological type and grade, and tumor biological profile. Subsequently, survivals were analyzed in relation to variables previously described. The data were analyzed with the aid of the statistical package SPSS (version 26.0), with p<0.05 is considered significant. Results: This study included a total of 203 patients, of which 158 (77.8%) survived and 45 (22.2%) died. Regarding deaths, 67.5% had a clinically compromised armpit (p<0.001) and 50% were in stage IV (p<0.001). In relation to overall survival, worse survival was observed for patients with clinically suspect lymph nodes (p<0.001), for tumors measuring between 2 and 5 cm and tumors larger than 5 cm in relation to tumors smaller than 2 cm (p<0.001), and for stages III and IV compared to stages I and II (p<0.001). There was no worsening of survival in relation to the histological type (p=0.39), histological grade (p=0.65), location of metastases (bone and visceral) (p=0.76), or biological profile (p=0.40). Conclusion: There were more deaths in relation to the clinically compromised axillary state and in stages III and IV. Larger tumors, more advanced staging, and a clinically compromised armpit worsened overall survival.
PERFORMED TREATMENT IN WOMEN WITH BREAST CANCER IN A SECONDARY PUBLIC HOSPITAL IN FEDERAL DISTRICT
Authors: Alves Amanda Ribeiro , Mosquéra Julia Milhomem , Cavalli Gianna Carolina Pereira , Ramos Larissa Feitosa de Albuquerque Lima , Vasconcelos Flavio Lucio
Published: February 2022

Objective: To evaluate treatments performed in women with malignant breast cancer treated at the mastology service of a public secondary-level hospital. Method: A cross-sectional study with women diagnosed with breast cancer from 2012 to 2019. Treatments evaluated were surgery, chemotherapy, radiotherapy, and hormone therapy. Data were analyzed using the SPSS software (vision 26.0), considering p<0.05 as significant. Results: We evaluated the data of 227 patients with tumors in stages I (10.1%), II (35.2%), III (26.9%), and IV (12.78%), with 55.5% of them between the ages of 40 and 60 years. Mastectomy was performed in 61.7% of the patients, with 84.6% not undergoing immediate reconstruction, while 12.8% undergoing late reconstruction. Techniques used were large dorsal muscle flap with prosthesis (29.4%), rectus abdominis muscle (26.5%), and only prosthesis (23.5%). Patients aged <0.001). Radiotherapy was performed in 56.8% of the patients, with those aged <40 years found significant (p=0.005). Hormone therapy was performed in 59.0% of the patients. The mean time between diagnosis and the start of chemotherapy was 134.8±126.5 days, and the average gap between treatments (chemotherapy/radiotherapy) was 188.2±204.6 days. Conclusion: Mastectomy was the most performed treatment, with a small part of the patients obtaining breast reconstruction. Most patients needed some type of complementary therapy, especially the younger ones. The average time between diagnosis and treatment was longer than that recommended by current legislation. Awareness measures and better access to women with breast complaints should be emphasized, especially in younger women.
ADVANCED BREAST METAPLASTIC CARCINOMA IN A YOUNG PATIENT: A CASE REPORT
Authors: Nunes Mirella Laranjeira , Anunciação Carlos Eduardo Caiado , Sampaio Vidianna Barbosa , Araújo Rossano Robério Fernandes , Jesus Cinthya Roberta Santos de , Santos Ana Leide Guerra dos , Pereira Bruno Pacheco , Beltrão Neto João Esberard de Vasconcelos
Published: February 2022

Objective: The aim was to evaluate an atypical case due to the rare pathologic finding of metaplastic breast carcinoma in a young woman, with an aggressive pattern. Case Report: A 45-year-old female presented with suspicious palpable right axillary lesion at level 1 topography of 2.5 cm size on the physical examination. No breast mass was palpable. Mammography was BIRADS classification 1. Breast and axillar ultrasound done 2 months before showed benign findings on the left side and axillary lymph node (LN) of 2.3 cm and breast nodule of 1.1×0.9 cm on the right side. Core-needle biopsy showed fibroadenoma in the right-sided breast nodule and metastatic carcinoma in the axillary LN. Immunohistochemistry expression of the markers was consistent with breast origin and was progesterone and estrogen receptors positive and HER-2 negative. Magnetic resonance imaging (MRI) showed this atypical LN with 1.5 cm. Clinical staging is T0N1M0. Neoadjuvant chemotherapy was performed with Adriamycin, cyclophosphamide, and paclitaxel. There was tumor remission with another MRI and ultrasonography showed the node metastasis with 1 cm. Right radical mastectomy was performed. Anatomopathology showed cytoarchitectural changes due to chemotherapy, complete pathological response in the LN, and immunohistochemistry unchanged. In addition, tumorectomy were performed in the left-sided nodule, with anatomopathology showing ductal ectasia and histiocitary abscess. Radiotherapy at the supraclavicular area and tangents was performed and tamoxifen was prescribed. The patient remained cancer free for 2 years after surgery. Conclusion: Metaplastic carcinoma represents less than 1% of breast cancers. Histologically, it is invasive and has subtypes based on the proportion of squamous, mesenchymal, and heterologous elements, such as cartilage and bone. Most common in women in the fifth decade and rare in younger than 35 years old. Usually, it is triple negative and has hematogenous dissemination, with little LN involvement and more distant metastasis. There is currently no described standard treatment. Owing to aggressiveness and poor prognosis, chemotherapy and modified radical mastectomy are performed. It is often refractory to standard regimens, so chemotherapy is indicated through the extrapolation of current data to invasive ductal carcinoma. The metastasis rate is about 35% in 5 years. The main prognostic factor is the size of the tumor at the time of diagnosis, LN metastasis, and poorly differentiated tumors.
HANDGRIP STRENGTH AND ISOMETRIC BILATERAL BENCH PRESS FOR UPPER INTERLIMB STRENGTH ASYMMETRY IN BREAST CANCER WOMEN, WITH OR WITHOUT LYMPHEDEMA
Authors: Santos Wanderson , Marques Vitor , Silva Naiany , Siqueira Gabriel , Schincaglia Raquel , Vieira Carlos
Published: February 2022

Purpose: The aim of this study is to compare upper interlimb strength asymmetry in breast cancer women (BCW), with or without lymphedema, using the handgrip strength test and the isometric bilateral bench press (IBBP) test. Methodology: Twenty-two BCW (age 52.04±8.62 years) were enrolled in a cross-sectional study, with a single-day testing. Ten participants with self-reported breast cancer – related lymphedema (BCRL) and 12 participants without BCRL were evaluated for the interlimb strength asymmetry. The average of the best three of four attempts of the handgrip strength and the IBBP was used to compare the maximal voluntary isometric contraction of each limb. To calculate the interlimb strength asymmetry, we used the following formula as a percentage: the modulus of left minus right side divided by the average between sides, then multiplied by 100. For the statistical analysis, we used the nonparametric Mann–Whitney U test for the handgrip strength and the independent t-test for IBBP. Results: The handgrip strength in BCW with lymphedema (27.62%±15.5%) showed a higher interlimb strength asymmetry than BCW without lymphedema (12.37%±16.29%; p=0.021). However, there was no difference in IBBP (with lymphedema 8.89%±5.81% versus without lymphedema 9.84%±7.98%, p=0.759). Conclusion: BCW with lymphedema might have higher interlimb strength asymmetry assessed by the handgrip strength test compared with BCW without lymphedema, but not in a multi-compound movement such as IBBP. More studies are necessary to confirm our findings.
BACKGROUND PARENCHYMAL ENHANCEMENT IN MRI EXAMINATION AND ITS CORRELATION WITH MAMMOGRAPHIC BREAST DENSITY AND CLINICAL AND TUMORAL CHARACTERISTICS
Authors: Reis Yedda Nunes , Mota Bruna Salani , Shimizu Carlos , Ricci Marcos Desiderio , Cardoso Natalia Paula , Baracat Edmund Chada , Filassi José Roberto
Published: February 2022

Objective: The aim of this study is to investigate the correlation between background parenchymal enhancement (BPE) in magnetic resonance imaging (MRI) examination and mammographic breast density (MBD) and also the association of BPE with clinical and tumoral characteristics. Methodology: The post hoc analysis from a prospective database (BREASTMRI trial) was performed. Patients with breast cancer stages 0 to III for breast-conserving surgery, from November 2014 to October 2018, were selected. All patients were evaluated with triple assessment and stratified by MBD. Then, they were randomized on a 1:1 basis in two groups whether to perform breast MRI. BPE was classified into four categories according to the ACR BI-RADS MRI (minimal, mild, moderate, and marked). The MBD was also classified according to the ACR BI-RADS (A, B, C, and D). Results: A total of 217 patients were included. The mean age was 57.4 years (33.7–81.7, SD 10.8). Of these, 25 (11.5%) patients had ductal carcinoma in situ (DCIS) and 192 (88.5%) had invasive breast cancer. The MBD classification was 12 (5.5%) for A, 93 (42.9%) for B, 99 (45.6%) for C, and 13 (6%) for D. The BPE classification was 105 (48.4%) minimum, 78 (35.9%) mild, 29 (13.4%) moderate, and 5 (2.3%) marked. Both MBD and BPE were similar in 63 (29%) of 217 patients and differed in 154 (71%) of 217 patients. There is no correlation between MBD and BPE (Spearman’s rank of 0.240, p<0.001). Minimum/mild BPE breasts were more frequent in postmenopausal women (p=0.01). B3 lesions were identified significantly higher in moderate/marked BPE breasts (p=0.04). The median lesion size in breast MRI for minimum/mild BPE breasts was 2.2 cm, and the pathological median size was 2.0 cm (p=0.001, 95%CI). Conclusion: The background parenchymal enhancement does not correlate with MBD.
DELAY IN THE DIAGNOSIS OF INVASIVE DUCTAL CARCINOMA DUE TO AN INFECTIOUS MASTITIS: CASE REPORT
Authors: Abreu Thiago Martins de , Pidde Arthur Gomes , Perillo Pedro Henrique de Ávila , Assunção Silvaleide Ataides , Santos Ianca Leandra , Cardoso Débora Sara de Almeida
Published: February 2022

Introduction: Breast cancer is the most common cause among women, with invasive ductal carcinoma (ICD) being the most prevalent and having great phenotypic and genotypic heterogeneity and the ability to metastasize. In turn, mastitis is an inflammation in the breast region, infectious or noninfectious causes, most commonly affecting lactating women. Objectives: It is intended to report a case of ICD accompanied by infectious mastitis and its reverberations. Case Report: A 27-year-old woman presents with a clinical history of mastitis in her left breast that occurred about 3 months ago after weaning her son. She also explained about the use of antibiotic therapy, multiple previous drainages, and local complication with engorgement, edema, erythema, and purulent drainage in the surgical ostium of the left breast. A new drainage and material collection was carried out. Computed tomography of the chest indicated a solid heterogeneous lesion, dense, irregular contours, with areas of air trapping, liquefaction, and cleavage plane with the left pectoralis major muscle and ipsilateral axillary adenomegaly. Pathological pathology confirmed the hypothesis of neoplasia, indicating grade III ICD in comedonecrosis. Immunohistochemistry demonstrated triple-negative character and culture, positivity for Corynebacterium renale. She started neoadjuvant chemotherapy with reduced breast volume and absence of secretion today. Discussion: This is a common and problematic situation in health systems. Repeated outpatient referrals, invasive processes without resolution, aggravating the patient’s case. Moreover, it is noted that mastitis has delayed the diagnosis of the neoplasm, which, depending on the delay, may result in a worse prognosis or a more aggressive or expensive treatment. Conclusion: The diagnostic investigation of neoplasms is of great importance in case of prolonged mastitis not responsive to treatment, due to the fact that many mastitides may come from neoplastic processes that generate the lesion, which can make this injured area conducive to bacterial proliferation.
ANALYSIS OF EARLY MORTALITY BY BREAST CANCER IN BRAZIL AND GOIÁS FROM 2010 TO 2019
Authors: Assunção Silvaleide Ataides , Batista Amanda Carlos de Lima , Amorim Eduarda Duarte Mota , Amoroso Giovanna Giulia de Carvalho , Reis Rebeka Gyovana Rodrigues , Sousa Lara Letícia Gaspar , Rahal Rosemar Macedo Sousa
Published: February 2022

Introduction: Breast cancer is the second leading cause of death among women, affecting mainly the age group of 50–59 years, the age at which screening tests are recommended. However, it has shown a progressive incidence below 50 years. For this reason, the objective is to analyze the statistical data on early mortality from breast cancer up to 50 years, in view of possible losses in diagnosis and early management. Methodology: A descriptive epidemiological study, a retrospective of time series, using the data from the Mortality Information System (SIM) of the Health Surveillance Secretariat of the Ministry of Health (SVS/MS) in the period of 2010 and 2019, in Brazil and in the State of Goiás, was analyzed. Malignant neoplasms of death and women up to 50 years of age were included as causes of death. The data were compared and tabulated in Excel. Results: Deaths due to malignant breast cancer in Goiás, between 2010 and 2019, were 35 (20–29 years old), 306 (30–39 years old), and 766 (40–49 years old), equivalent to 26.2% of the total number of deaths in all age groups (1,107 cases). In Brazil, deaths were 1,149 (20–29 years old), 9,876 (30–39 years old), and 24,586 (40–49 years old), totaling 23.3%. Conclusion: According to the analysis, it is possible to point to an increase in deaths, especially for those aged 40–49 years. The lack of inclusion of women in this group interferes with the prognosis, since it makes the late diagnosis feasible and, in more advanced stages, causes less chances of cure. Possible adaptations and strategies for screening this public and coverage by public health systems must be considered.
NTRK MUTATION IN ADENOID CYSTIC CARCINOMA: A RARE TYPE OF TRIPLE NEGATIVE
Authors: Assunção Silvaleide Ataides , Nascimento Vinicius Lemos , Brito Bruno Henrique de Aguiar , Neves Carolina Daher de Alencar , Silva Laura Queiroz da , Souza Pedro Vinicyus Novais e , Azevedo Fernando Santos de , Santana Lanúscia Morais de
Published: February 2022

Introduction: Breast cancer is one of the neoplasms that most cause death in women. Among these, there are some subtypes of greater biological aggressiveness, such as triple negative and HER overexpressed, which are associated with greater recurrence and mortality. Adenoid cystic carcinoma (ACC), salivary gland type, represents less than 0.1% of primary breast carcinomas and has indolent biological behavior and favorable prognosis compared with nonspecial triplenegative types. Case Report: A 51-year-old woman diagnosed with locally advanced ACC in the right breast, with negative immunohistochemistry for hormone receptors and HER2, underwent quadrantectomy with upfront axillary dissection, followed by adjuvant radiotherapy. After 12 years of diagnosis, she presented significant back pain, with magnetic resonance imaging scan evidencing bone lesion without medullary involvement in D7 and L1 suggestive of the secondary implant. Anatomopathology revealed the same histology as the primary tumor. Re-evaluation of chest tomography showed progression of pulmonary disease, 5 months after diagnosis of the first metastasis, underwent segmentectomy, with descriptive pathology identical to the initial lesion. Due to the oligoprogression and tumor type, somatic genetic research of the lung material was requested, which revealed a mutation in the NTRK gene, patient is still waiting for Larotrectinib in court. Discussion: The tumor has an unusual histological type, rare occurrence, slow progression course, and the absence of lymph node metastasis; the average incidence is around age 60. In this case, a young patient presented an ACC tumor with lung and bone metastasis. Due to the rarity, there is no definitive consensus regarding the ideal treatment, with the literature referring to the choice of mastectomy. Conclusions: Although malignant breast neoplasms and nonspecial subtypes, such as ductal and triple negative, have a poor prognosis, breast carcinoma of this aforementioned type has a favorable prognosis. The search for driver mutations in cancers of special types, together with the advances in genetic medicine, allows satisfactory results with target-specific treatments.
ANALYSIS OF PATIENTS WITH LOCALLY ADVANCED BREAST CANCER TREATED AT ICESP
Authors: Nobrega Gabriela Bezerra , Mota Bruna Salani , Freitas Gabriela Boufelli de , Maesaka Jonathan Yugo , Gonçalves Rodrigo , Oku Sérgio Mitsuo Masili , Cunha Angela Francisca Trinconi da , Filassi José Roberto
Published: February 2022

Objective: The aim of this study was to assess the oncological efficacy of breast-conserving surgery (BCS) after neoadjuvant therapy (NT) in patients with invasive locally advanced breast cancer (LABC). Methodology: A retrospective cohort study was conducted at the Instituto do Cancer de São Paulo Octavio Frias de Oliveira (ICESP), with LABC (Stages IIb– III) treated with NT between 2010 and 2015. The endpoints were disease-free survival (DFS), local disease-free survival (LDFS), overall survival (OS), and residual tumor volume, considering pathological complete response (PCR) as ypT0 ypN0. The multivariable analyses were performed by using the Cox proportional hazard models. Results: In this study, 529 patients were included. The mean age was 52.7 (51.53–53.90). All patients were submitted to NT, i.e., 95.5% was submitted to neoadjuvant chemotherapy and 4.5%, hormone therapy. The mean follow-up was 62.33 (60.01–64.65) months. The PCR was identified in 12.7%. The BCS was performed in 24.6% (130) patients versus 75.4% (399) of mastectomies (MTs). There were no differences in 13% versus 9.2% (95%CI; p=0.2) LDFS for MT and BCS. The DFS was lower at 55.4% in the MT group versus 77.7% in the BCS group (95%CI; p30 (RR1.8; 95%CI 1.331–2.618; p=0.000). The type of surgery had no impact on mortality (RR 1.47; 95%CI 0.945–2.298; p=0.08). Conclusion: In our population, the BCS does not affect the LDFS rates and mortality, which seems to be safe to perform in patients who desire to conserve the breast after neoadjuvant treatment. PCR, clinical stage, and Ki67 had an important impact on mortality.
ASPECTS OF BREAST CANCER DIAGNOSIS AND DELAYED TREATMENT IN BRAZIL
Authors: Rosa Isabella Inês Rodrigues , Valadares Alexandre Santana , Paula Douglas Marques de , Prudente Tiago Paiva , Martins Maria Elvira Freitas , Barros Guilherme Ferreira , Zara Ana Laura de Sene Amâncio
Published: February 2022

Objective: Breast cancer is one of the leading causes of death in women worldwide. Several studies highlight the correlation between delayed treatment and high mortality. However, few researchers have addressed the main reasons for long delays in the healthcare system. This study aims to analyze different aspects influencing the postponement of treatment in Brazil. Methodology: An ecological approach using the secondary data from the Oncology Panel of the Brazilian Unified Health System (SUS). The data were collected on February 13, 2020, and included the diagnoses of breast cancer (ICD-10: C50 and D05) from 2015 to 2020. The aspects analyzed included the waiting time for the first treatment, procedure, staging, and region. Anatomopathological diagnoses made after a surgical procedure were not included. Results: According to the Brazilian laws, oncological patients need to start treatment within 60 days (5). However, the data reveal that only 45.22% of breast cancer patients (stages 2–4) started the treatment within 60 days. This is more alarming when looking at the procedures. Over half of the patients submitted to chemotherapy and 76.8% submitted to radiotherapy received their treatment after 60 days from the diagnosis. Interestingly, our geographic analysis did not reveal significant disparities among regions. The lower-income regions had 49.01–57.07% of patients treated after the recommended time frame. The higher-income regions had values from 43.44% to 54.44%. Conclusion: Despite the knowledge that later treatments result in worse outcomes and the legal right of earlier treatment, our results show a current controversial frame in Brazil. Most patients take longer than recommended, and the worst scenario is for radiotherapy patients. No substantial differences were found among lower- and higher-income regions, although it is likely that further analysis with different approaches could be more sensitive to deny or confirm this assumption.
Audiências públicas do licenciamento ambiental - reflexões sobre conflitos socioambientais e direitos humanos
Authors: LIMA RENATA MARQUES GALVAO DE , Marques Maria Celeste Simoes
Published: February 2022

Introdução

O presente resumo expandido apresenta algumas características das pesquisas comumente realizadas no âmbito e sob orientação e coordenação do GEDHJUS - Grupo de Estudos Direitos Humanos e
EVGENI PACHUKANIS E A CARACTERIZAÇÃO DO FASCISMO
Authors: Farias João Guilherme Alvares de
Published: February 2022

João Guilherme A. de Farias
Doutorando e Mestre em Ciências Sociais (Unifesp).
Bacharel em direito (PUC-SP).
E-mail: alvares.farias@unifesp.br

Introdução
O presente texto é resultado das leituras
NOVAS ROTAS PARA PENSAR A POLÍTICA PÚBLICA A PARTIR DE UM OLHAR DECOLONIAL: A OPERACIONALIZAÇÃO DA ASSISTÊNCIA SOCIAL JUNTO A POVOS ORIGINÁRIOS EM SÃO GABRIEL DA CACHOEIRA-AM.
Authors: Tupinambá Taís da Cunha Ferreira
Published: February 2022

NOVAS ROTAS PARA PENSAR A POLÍTICA PÚBLICA A PARTIR DE UM OLHAR DECOLONIAL: A OPERACIONALIZAÇÃO DA ASSISTÊNCIA SOCIAL JUNTO A POVOS ORIGINÁRIOS EM SÃO GABRIEL DA CACHOEIRA-AM.

Taís da Cunha Ferreira
Bigger and Complex Is Not Always Better. The Creation of Composite Sustainable Tourism Indicator to Compare Destination Development
Authors: MARCİŠ Matúš , GAJDOŠÍK Tomáš
Published: February 2022

Destination managers need indicators for monitoring, comparing and decision-making purposes about sustainable tourism development. There have been several initiatives to set the sustainable tourism indicators, however, the indicators are either too complex, data collection is difficult, or the analysis requires expert statistical knowledge. Therefore, this article aims to propose a user-friendly method that allows destination managers and decision makers to process tourism data and integrate them into one composite indicator. To help destination managers in their work, this paper reviews the most used methods to create composite indicators, and with the help of the Delphi method among experienced tourism leaders, it proposes a tool that allows destination managers to compare sustainable tourism development of destinations. The results present the application of a simple composite sustainable tourism indicator on the example of eight destinations in Slovakia. The paper provides useful guidance in data collection, analysis and decision-making concerning sustainable tourism development.
Behavior of fluorescent Pseudomonas under different concentrations of heavy metals (Zn and Cu)
Authors: Oubeidillah Youssoufa Ali  , Adiouma Dangue  , Demba Diaw  , Mame Arama Fall Ndiaye  , Tahir Abdoulaye Diop
Published: February 2022

The use of chemical fertilizers has resulted in the depletion of soils in mineral elements and telluric microorganisms. Thus, for an improvement in crop growth, the exploitation of telluric microorganisms such as Pseudomonas can be an alternative. Laboratory work has made it possible to isolate strains of Pseudomonas from the rhizospheres of tomato, eggplant and onion. These strains were also tested in the presence of different concentrations of certain metals (CuSO4 and ZnSO4 (0, 1, 3, 4, 5 and 6 mmol/l). The tests carried out in the laboratory in the presence of Cu and Zn revealed a very significant reduction in the number of colonies of the strains of Pseudomonas for the concentrations of 5 and 6 mmol/l. The results showed better zinc tolerance for both tomato and onion rhizosphere strains. In the presence of Cu, the strain isolated from tomato rhizosphere shows more tolerance to heavy metals. These results made it possible to isolate different strains of Pseudomonas and to specify their tolerance thresholds for heavy metals.