bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect OF FERMENTATION TIME BY BACILLUS SUBTILIS STRAIN FNCC 0059 ON THE CONTENT OF PHYTOCHEMICAL COMPOUNDS AND ANTIOXIDANT ACTIVITY IN VITRO FROM UNDIS BEAN (CAJANUS CAJAN [L.] MILLSP)
Authors: Winanti Kadek Dinda Ayu Sri , Sumardika I Wayan , Indrayani Agung Wiwiek , Mahendra Agung Nova
Published: July 2024

Background: Pigeon pea (Cajanus cajan [L] Millsp) is a type of legume rich in phytochemical compounds, phenolic compounds, flavonoids, tannins and anthocyanins. Bacillus subtilis is a microbe with excellent physiological characteristics. This study aims to determine the effect of pigeon pea fermentation by B. subtilis FNCC 0059 on the phytochemical characteristics and antioxidant activity of the extract in vitro.
Methods: The study was a true experimental post test only control group design method. The samples were divided into 6 groups, the control group consisted of a negative control group, 1 ml of 0.1 mM DPPH plus 1 ml of methanol, and the positive control, 1 ml of quercetin solution plus 1 ml of 0.1 mM DPPH and the treatment group with variations in fermentation time of 16 hours. 24 hours, 32 hours and 40 hours, 1 ml of sample plus 1 ml of 0.1 mM DPPH (1:1). The data were analyzed using a data processing application and One Way Anova method.
Results: The levels of total phenols, flavonoids and tannins increased highest at 24 hours of fermentation, while anthocyanins at 16 hours of fermentation. The best antioxidant activity test was at 40 hours of fermentation.
Conclusion: Fermentation duration has no effect on the phytochemical characteristics and antioxidant activity of the extract.
Keywords: Antioxidant activity, Phytochemical Compounds, Pigeon pea, Effect of fermentation time, Bacillus subtilis FNCC 0059.
THE EFFECT OF NOISE EXPOSURE ON THE AVERAGE NUMBER OF TEMPORAL LOBUS NEURONS IN ADULT WISTAR RATS
Authors: Suka Astini Dewa Ayu Agung Alit , Evayanti Luh Gde , Witari Ni Putu Diah , Sumadewi Komang Trisna , Prima Dewi A.A.A Asri , Anthony Kerans Fransiscus Fiano , Kurniawati Ida
Published: July 2024

Noise is defined as unwanted and disruptive sound, considered an environmental stressor and disturbance. Noise encompasses many aspects of modern communities, including work environments. The damaging effects of noise primarily result from the unrestricted production of free radicals into the auditory organs. Exposure to noise causes various health problems, such as hearing impairment, sleep disturbances, and interference with individual performance. Reactive oxygen species (ROS), also known as free oxygen radicals, are normal by-products of cellular aerobic metabolism. These unstable molecules can damage cellular lipids, proteins, and nucleic acids in DNA if the antioxidant balance is disrupted. Acute and chronic exposure to loud noise generates excessive free radicals and disrupts extra-auditory organs such as the nervous, endocrine, and cardiovascular systems. The purpose of this study is to analyze the relationship between noise exposure and the number of neurons in the temporal lobes of Wistar rats. The research design used is a laboratory experimental design, specifically a pure experimental design, implemented with the randomized posttest-only control group design. The research sample consists of 30 male Wistar rats randomized into 2 groups, control and treatment. The treatment group is exposed to 95dB noise for 4 hours per day for 14 days. The rats are then euthanized, and their brain tissue is fixed with 10% neutral buffered formalin. Assessment is performed using Hematoxylin Eosin staining, and analysis is conducted blindly on the average number of neurons in the rat's temporal lobes. Data is subjected to normality testing using the Shapiro-Wilk test and analyzed using independent t-tests for parametric comparison. The results show a significant difference in the mean number of neurons in the temporal lobes between rats exposed to noise and the control group (p <0.005). The conclusion of this study is that noise affects neuron cells in the temporal lobes.
Keywords : noise, temporal lobe, neurons.
Pengaruh Teknik Injeksi Multipel Sodium Dodecyl Sulfat (SDS) pada Deselularisasi Kulit Tikus Untuk Pembuatan Perancah (Scaffold) Kulit
Authors: Dewi Anak Agung Istri Agung Putri Septiani , Lestarini Asri , Dewi AA Ayu Asri Prima
Published: July 2024

Deselularisasi merupakan proses pembuatan perancah (scaffold) dengan mengisolasi matriks ekstraseluler (ECM). Teknik yang paling sering dilaporkan untuk mendeselularisasi jaringan kulit yaitu perfusi, namun terbatasnya pompa peristaltik membatasi penggunaan teknik ini. Teknik yang lebih efisien perlu di coba untuk mengetahui apakah efektif untuk mendeselularisasi jaringan kulit. Sehingga penelitian ini bertujuan untuk mengetahui pengaruh teknik injeksi multipel SDS pada deselularisasi kulit tikus untuk pembuatan perancah (scaffold) kulit. Metode penelitian yang digunakan adalah penelitian eksperimental dengan membagi dua kelompok yaitu kelompok perlakuan dan kelompok kontrol. Kemudian dilakukan isolasi jaringan dan proses deselularisasi. Selanjutnya hasil sampel yang telah didapat akan dilakukan evaluasi histologi, dan dinilai berdasarkan kriteria atau penilaian deselularisasi yaitu tidak adanya inti sel yang terlihat dalam analisis histologis dengan Hematoksilin Eosin (HE). Hasil penelitian kelompok perlakuan menunjukkan gambaran makroskopis yang tampak bening pada bagian dermis dan putih pada bagian epidermis dan gambaran mikroskopis memperlihatkan hilangnya sel dengan mempertahankan ECM, dibandingkan dengan kelompok kontrol yang memperlihatkan gambaran makroskopis jaringan yang berwarna merah pada bagian dermis dan tampak putih kecoklatan pada bagian epidermis, dan gambaran mikroskopis memperlihatkan gambaran sel yang masih utuh. Kesimpulan dari penelitian ini yaitu injeksi multipel SDS merupakan teknik yang dapat menghasilkan kulit tikus terdeselularisasi dengan mempengaruhi hilangnya sel pada jaringan untuk pembuatan perancah (scaffold) kulit.
THE RELATIONSHIP OF KNOWLEDGE AND DIET COMPLIANCE WITH BLOOD SUGAR LEVELS IN DIABETES MELLITUS PATIENTS IN THE POLYCLINIC ROYAL PRIMA JAMBI HOSPITAL IN 2023
Authors: Suryani Dini Dini , Sari.AZ Winna Kurnia , Mulyati Sri , Minas Sari Putri
Published: July 2024

The World Health Organization (WHO) reports that 422 million people globally suffer from DM as of May 2020 and based on this data, Indonesia is ranked fourth with the highest number of DM sufferers after China, India and the United States. Based on the same report, it is estimated that in 2030 there will be 21.3 million DM sufferers in Indonesia. The incidence of DM in Jambi Province in the 2013 Riskesdas results was 1.2%, then increased to 1.4% in 2018. This study aims to determine the relationship between knowledge and dietary compliance with blood sugar levels in diabetes mellitus patients at the Royal Hospital Polyclinic. Prima Jambi City. This research is a quantitative study using cross sectional research. This research was conducted at the Royal Prima Hospital, Jambi City and was carried out in August 2023. The population of this study were outpatients at the Royal Prima Hospital, Jambi City. The sampling technique was taken using an accelerated sampling technique of 85 respondents. Data processing was carried out using univariate and bivariate analysis using the Chi Square test. The research results showed that there was no significant relationship between knowledge and dietary compliance with blood sugar levels at the Royal Prima Hospital, Jambi City. It is hoped that the Royal Prima Hospital will need to provide/create an educational program for DM patients who seek treatment at the Internal Medicine Polyclinic.
Keywords: Knowledge., Diet Compliance., Blood Sugar Levels., Diabetes Mellitus.
PERAN TERAPI HBO TERHADAP PERBAIKAN KLINIS DAN KUALITAS HIDUP PASIEN DEPRESI
Authors: Devi Ismylatifa , Rahardjo Indarwati Mulio , Ayu P Intan Tiara , Azizah Ismi , Mardinata P Ivan , Nandaka I Ketut Tirka , Poerwanto Eka
Published: July 2024

ABSTRAK
Depresi adalah gangguan mood dengan gejala merasa kosong, kelelahan yang berlebihan, hilang motivasi untuk beraktivitas hingga menimbulkan keinginan untuk bunuh diri. Berdasarkan data WHO bunuh diri pada orang depresi merupakan salah satu penyebab utama kematian pada usia produktif. Terapi Oksigen Hiperbarik (HBOT) adalah terapi pemberian oksigen 100% dalam tekanan lebih dari 1 ATA. Beberapa studi menunjukkan manfaat signifikan dari HBOT pada tubuh, salah satunya meningkatkan produksi antioksidan tubuh. Studi ini akan mengkaji lebih lanjut mengenai peran HBOT terhadap perbaikan klinis dan kualitas hidup pasien depresi yang diukur melalui kuisioner HDRS dan BDI.
Desain studi adalah kuasi eksperimen, sebanyak 7 pasien dilakukan pemeriksaan tingkat depresi dengan kuisioner HDRS dan BDI. Pasien dengan skor di atas 10 (menunjukkan depresi ringan-berat) selanjutnya mengisi kuisioner untuk kualitas hidup. Setelah penilaian dengan kuisioner, pasien mendapatkan terapi oksigen hiperbarik selama 5 hari. Setelah pemberian HBOT dilakukan pemeriksaan ulang perbaikan klinis dan kualitas hidup.
Hasil penelitian menunjukkan pada sebelum dan sesudah terapi HBO terdapat perubahan pada perbaikan klinis melalui penilaian HDRS (p=0.001) dan BDI (p=0.012) dan kualitas hidup pasien dengan penilaian WHOQOL domain 1 (p=0.014), domain 2 (p=0.071), domain 3 (p=0.022), domain 4 (p=0.013). Perubahan signifikan (p<0.005) pada hasil pretest dan posttest menunjukkan perbaikan klinis dan kualitas hidup pasien meningkat sebelum dan sesudah terapi HBO.
Kata kunci :  Depresi, Terapi Oksigen Hiperbarik, Kualitas Hidup
Adult Women with Congenital Adrenal Hyperplasia (CAH)
Authors: Setiawan Muhammad Rudi , Arif Ichsan , Utama Bobby Indra
Published: July 2024

Introduction : Congenital Adrenal Hyperplasia (CAH) is the most common cause of ambiguous genitalia. It is a genetic disorder that occurs due to failure or disruption of the formation of enzymes which play a role in the production of cortisol and aldosterone and can cause fusion of the labia, clitoromegaly, and a fusion of the vagina and distal urethra.Case Reports:A 32-year-old patient, unmarried, came to the urogynecology department complaining of thickening of the upper genitalia that resembles male genitalia. This problem has been known to the patient since she was 16 years old and was brought to the doctor at the age of 21 and diagnosed with congenital adrenal hyperplasia. The patient has had menstruation since she was 14 years old, but it is irregular. Since 8 years ago, the patient has been regularly taking hydrocortisone from an internal medicine specialist but has never been to the obstetrics and gynecology department for 8 years, now the patient comes to the urogynecology department because she wants to get married. When the patient was in school, she grew up like a normal woman and have good academic abilities. In the family history, there was no family history of congenital abnormalities. From physical examination, her height is 150 cm. She shows the habitus of external body like a woman. On genital examination found no formation of labia, clitoromegaly. Karyotype 46, XX. Ultrasonography found uterus and ovaries within normal limits.Conclusion:Counseling, both surgical and non-surgical treatment with a multidisciplinary approach, will give good results in patients with CAH. Rapid diagnosis and treatment will provide good management for patients with CAH. Surgery in the form of reducing the size of the clitoris (while maintaining the function of sensation), as well as expanding the vaginal opening can help in these patients to improve the patient's quality of life.Keywords: Congenital Adrenal Hyperplasia; clitoromegaly; unmarried
MODE OF DELIVERY DOES NOT CORRELATE FETAL OUTCOME IN PREGNANCY WITH COVID-19 AT DR. M. DJAMIL HOSPITAL PADANG
Authors: Farnas Heri , Sriyanti Roza
Published: July 2024

Introduction: Corona Virus Disease 2019 (COVID-19) was first reported in Wuhan, China. Knowledge about COVID-19 infection in relation to pregnancy and the fetus is still limited. Report from China shows high rate of caesarean delivery (> 90%) due to the suspicion for vertical transmission. Globally there is an increase of caesarean delivery in women with COVID-19 infection. Clinical implications mode of delivery in pregnancies with COVID-19 infection are not fully understood.Objective:Â The aims of this study to assess differences in fetal outcome based on the mode of delivery in pregnancies with COVID-19 infection.Methods: This observational analytic study with cross sectional study design was conducted in single center at dr. M. Djamil General Hospital Padang from March 2020-March 2021. All study subjects qualified to inclusion and exclusion criteria included. The fetal outcome analyzed based on APGAR scores and COVID-19 status in newborn baby using Mann-Whitney test.Results:Â A total of 49 patients were analyzed. The results showed mean APGAR score 1 minute in the vaginal delivery was lower than caesarean delivery (6.87Â±1.06 vs 7.38Â±0.82) but not significant (p=0.09). No significant difference between vaginal delivery and caesarean delivery based on APGAR score 5 minutes (p=0.19). None newborn babies infected with COVID-19 in both groups.Conclusions:Â There was no difference of fetal outcome based on the APGAR score in pregnancies with COVID-19 infection by mode of delivery. There were no cases of infants with COVID-19 infection in both groups.Keywords: COVID-19, mode of delivery, APGAR score
Pregnancy confirmed COVID-19 in hospital Dr. M. Djamil Padang periode 2020-2021
Authors: Aladin Aladin , Linosefa Linosefa , Alfi Putra Muhammad Rafky
Published: July 2024

Introduction: Coronavirus disease 2019 (COVID-19) caused a highly acute respiratory infection and high mortality. Symptoms of COVID-19 would be more severe if it affects people at high risk, one of which is pregnant women. This study aims to determine the characteristics of pregnant women with confirmed COVID-19 at RUSP Dr. M. Djamil Padang Objective: to find out the profile of the maternal charactheristic confirmed COVID-19 in hospital Dr. M. Djamil Padang Periode 2020-2021. Methods: This type of research is descriptive with a total sampling technique using secondary data, namely patient medical records. The sample of this study were all pregnant women who were confirmed to have COVID-19 at RSUP Dr. M. Djamil Padang for the 2020-2021 period with a total sample of 186 patient medical records. Univariate data analysis is presented in the form of frequency distribution and data processing using the Computerized SPSS version of the IBM version 26.0. Results: The highest age group was 20-35 years old (78%), the most addresses were Padang City (43,5). %), the most gravida status was multigravida (71,5%), the most parity status was multipara (38,2%), the most gestational age was third trimester (81,7%), the most clinical symptoms are asymptomatic (44,1 %), and the most comorbid status was without comorbid (82,3%). Conclusion: The most pregnant women have confirmed COVID-19 at RSUP Dr. M. Djamil Padang in 2020-2021 with characteristics of age 20-35 years, address in Padang City, status of multigravida and multiparous pregnancy, third trimester gestational age, asymptomatic and no comorbidities.
Mayerâ€“Rokitanskyâ€“Kusterâ€“Hauser syndrome (MRKH) and Ovarian Cyst : A Rare Case
Authors: Meuthia Susan , Sari Yulias Margaretta
Published: July 2024

Background:Â In the most recent publications on Mayer-Rokitansky-KÃ¼ster-Hauser (MRKH) syndrome, the uterine remnants and ovaries in patients may develop uterine remnant leiomyoma, adenomyosis, or ovarian tumor, and this can lead to problems in differential diagnosis. Here we summarize the diagnosis methods and available interventions for ovarian tumor in MRKH syndrome, with emphasis on the relevant clinical findings and illustrative relevant case. According to the clinical findings and illustrative relevant case, with the help of imaging techniques, ovarian tumors can be detected in the pelvis in patients with MRKH syndrome and evaluated in terms of size. Laparoscopy could further differentiate ovarian tumors into different pathological types. In addition, laparoscopic surgery not only is helpful for the diagnosis of MRKH combined ovarian tumor, but also has a good treatment role for excising ovarian tumor at the same time. Moreover, laparoscopic removals of ovarian tumor can be considered as a safe and reliable treatment for conservative management.Case report:Â 25-year-old nulliparous woman with female phenotype and normal secondary sex development presented with complaints of primary amenorrhea and difficulty in sexual intercourse.Â Physical examination revealed that there were no vaginal and uterus structure. A transvaginal ultrasound examination showedÂ absent ofÂ uterine .Â normal rightÂ ovariesand cystic mass in left adnexaÂ .Â Laparoscopy cystectomy and amniograft vaginoplastyÂ Â was performed in this patient. Histopatology result showed Cystadenoma srous ovarii with borderline serous ovarii.Conclusion:Â Rarely ovarian cyst was associated with MRKH . Although malformation are associated with MRKH syndrome. AssociationÂ Â beetween MRKH syndrome and ovarian cyst can be foundÂ
Clinical Characteristics, Laboratory, Maternal and Fetal Outcomes in Pregnancy with Covid-19 at RSUP dr. M. Djamil Padang
Authors: Sriyanti Roza , Farnas Heri , Djanas Dovy
Published: July 2024

Introduction : The data obtained from various studies about covid-19 conducted in severalhospitals in the world are currently considered not sufficient to provide a clinical picture thatoccurs in pregnancies with Covid-19 infection. The aims to provide an overview of the clinical,laboratory, maternal and fetal outcomes in pregnancy with Covid-19 infection at dr. M. DjamilPadang.Methods: This study used a descriptive design with data collection starting from March 01,2020 - March 31, 2021 based on medical record data. Carried out in a single center at RSUPdr. M. Djamil Padang in pregnant patients with confirmed Covid-19 by PCR examination.Results: Total 136 pregnant patients confirmed Covid-19 by PCR examination. Most of thesymptoms were asymptomatic (47.1%) and without any comorbidities (76.5%). There were 3patients who experienced critical symptoms (2.2%). Maternal mortality was found at 2.3% andfetal death 4.7%. The values of d-dimer and NLR were found increasing significantly,2025.35Â±1392.18 for d-dimer and 6.39Â±4.43 for NLR. Pregnancy terminations done for 77.9%patients with cesarean section is the most method (83%). There were 4 cases (3.8%) of babiesinfected with Covid-19 from mothers who had pregnancy terminations.Conclusions: Most cases had asymptomatic clinical symptoms (47.1%). There are 2.3%cases of maternal death and 4.7% cases of fetal death. Most of the pregnancy terminationswere performed by cesarean section (88%). On laboratory examination, there was a significantincrease in maternal d-dimer (2,025.35Â±1.392.18) and NLR (6.39Â±4.43) in pregnancies withCovid-19.
EARLY HAEMORRHAGE POSTPARTUM (HPP); WITH COMPLICATION DISSEMINATED INTRAVASCULAR COAGULATION, SEPSIS, ACUTE KIDNEY INJURY
Authors: Oktavian Rizki , Sriyanti Roza , Taslim Emilzon
Published: July 2024

Â AbstarctÂ Background :Â Hemorrhage Postpartum (HPP) is the leading cause of maternal death worldwide with an incidence of 5%-10% of all deliveries. 70% of cases of HPP are caused by atony of the uterus. If HPP is not handled properly, it will cause worsening of the patient's condition which causes various multiorgan complications.Objectives :Â To discuss the management of HPP cases complicated by DIC, sepsis and AKI.Method :Â case report.Case :Â A female patient, 36 years old, was referred from a private hospital to PONEK RSUP Dr. M. Djamil Padang with a diagnosis of decreased consciousness ec suspected sepsis in post SCTPP oi used SC 2x + post relaparotomy oi bleeding subfascia + moderate anemia. After surgery, the patient looked pale and the hemoglobin was 7, then relaparotomy was done and done B-lynch oi uterine hypotony. After relaparotomy, the patient experienced worsening then referred to the hospital. The patient arrives with hipovolemic shock + AKI + Sepsis + DIC , then the condition improvement is carried out in ROI and hysterectomy relaparotomy is performed. The patient has worsened, maximum treatment has been carried out from the intersivist, but the patient's condition continues to worsen and eventually dies.Conclusion : Early diagnosis and rapid treatment through a multidisciplinary team and the availability of an Intensive Care Unit (ICU) can prevent complications and reduce morbidity and mortality.
From Molar Pregnancy, Thyrotoxicosis, to Pulmonary Hypertension: A Case Report
Authors: Saputra Rudi , Azra Dieni , Aswad Fidya Mayastri , Nurtanio Setyawan
Published: July 2024

Background: Molar pregnancy is a benign condition with the dominant symptom being dark brown to bright red bleeding from the vagina. This disease can induce hyperthyroidism and result in pulmonary hypertension. This case report describes a patient who had molar pregnancy with thyrotoxicosis and pulmonary hypertension.Case: A 30-year-old woman presented with complaints of lower abdominal pain for the last month. The patient feels that her stomach has enlarged in the last 3 months. Other complaints include bleeding and observed bubbles from the birth canal, shortness of breath, and chest pain. The serum cobas Î²-hCG level of 7954.00 mIU/mL. On abdominal ultrasound examination, vesicles formed a honeycomb appearance, measuring 7.4 cmÃ—5.3 cm. Hematologic laboratory tests revealed low TSH levels (<0.01 Î¼IU/mL), T3 levels of 2.35 ng/ml, and FT4 levels of 2.62 ng/dL. The results of the echocardiography examination showed there is a high probability of pulmonary hypertension.Conclusion: Molar pregnancy can exacerbate thyrotoxicosis through hCG activity. Smoking and breastfeeding also have similar effects. Consequently, increased thyroid hormone levels can worsen or cause pulmonary hypertension.
PENERAPAN MEDIA PUZZLE UNTUK MENINGKATKAN KETERAMPILAN MEMBACA PERMULAAN SISWA KELAS I SDN 16 SUNGAI GOA
Authors: Mustajab Amin , Rahmawati Puji , Yenda Kristina
Published: July 2024

Penelitian ini dilakukan untuk meningkatkan keterampilan membaca permulaan siswa kelas 1 di SDN 16 Sungai Goa dengan menggunakan media puzzle sebagai alat bantu pembelajaran. Penelitian tindakan kelas dilaksanakan dalam tiga siklus dengan model Kurt Lewin, melibatkan 16 siswa (delapan laki-laki dan delapan perempuan) pada semester genap Tahun Pelajaran 2021/2022. Instrumen pengumpulan data yang digunakan adalah tes, lembar observasi, dan catatan lapangan. Hasil penelitian menunjukkan bahwa pada siklus I, tingkat keberhasilan siswa dalam membaca hanya mencapai 55,56% dan aktivitas pembelajaran yang dilakukan guru hanya mencapai 63,23%. Pada siklus II, tingkat keberhasilan siswa meningkat menjadi 82,5% dan aktivitas pembelajaran guru mencapai 85%. Sedangkan pada siklus III, tingkat keberhasilan siswa meningkat menjadi 95,05% dan aktivitas pembelajaran guru mencapai 93,75%. Dalam penelitian ini menunjukkan bahwa penggunaan media puzzle dalam pembelajaran membaca permulaan dapat meningkatkan keterampilan membaca siswa kelas 1 di SDN 16 Sungai Goa. Selain itu, media puzzle juga dapat membuat pembelajaran lebih menyenangkan dan efektif. Oleh karena itu, disarankan kepada guru untuk merancang pembelajaran membaca dengan baik dan menggunakan kegiatan permainan seperti media puzzle dalam pembelajaran untuk meningkatkan minat membaca siswa.
STRATEGI WALI KELAS DALAM MENGATASI KESULITAN BELAJAR SISWA
Authors: Tri Sutrisno  , Yuliawati Ningsih Endang
Published: July 2024

Abstrak
Penelitian strategi wali kelas dalam mengatasi kesulitan belajar siswa kelas II di SDI Al-Furqon menggunakan jenis penelitian kualitatif dengan pendekatan deskriptif. Hasil penelitian ini adalah: Pertama, strategi wali kelas dalam mengatasi kesulitan belajar adalah memberikan motivasi kepada siswa, memberikan latihan, ketika tinggal sedikit siswa yang tidak paham, wali kelas menerangkan kembali menggunakan pendekatan personal atau bisa di sebut one by one, serta memberikan waktu khusus pada saat jam istirahat kepada siswa yang mengalami kesulitan belajar yaitu membaca. Kedua, faktor penghambat dan pendukung, faktor pendukung adalah dari orang tua siswa, dalam diri siswa sendiri dimana siswa sangat semangat dalam melakukan bimbingan membaca pada saat jam istirahat. Faktor penghambat adalah siswa yang tidak masuk ke sekolah, kurangnya fasilitas yang memadai, dan teman luar sekolah atau lingkungan sekitar. Ketiga, pengaruh peran wali adalah orang tua yang menyemangatkan dengan cara memberikan motivasi siswa di rumahnya sedangkan wali kelas yang mengontrol semua pemahaman siswa di sekolah. Jadi wali kelas mempenyai peran yang lebih besar.
Kata Kunci: Strategi, wali kelas, kesulitan belajar
PENGARUH MODEL BLENDED LEARNING TERHADAP HASIL BELAJAR SISWA KELAS III SD NEGERI 1 PEGUYANGAN
Authors: Suastini Ni Nyoman , Wisarja I Ketut , Suparwati Ni Putu
Published: July 2024

ABSTRAK
            Penelitian ini bertujuan menganalisis pengaruh model pembelajaran blended learning terhadap hasil belajar siswa kelas III sekolah dasar  pada tema 6 (energi dan perubahannya). Jenis penelitian ini adalah quasi experiment dengan rancangan pretest-posttest nonequivalent control group design. Populasi penelitian ini adalah siswa kelas III SD Negeri 1 Peguyangan yang terdistribusi kedalam dua kelas reguler (70 siswa). Sample diambil melalui teknik simple random sampling dan berjumlah dua kelas (70 siswa). Data yang dikumpulkan dalam penelitian ini adalah data tes literasi sains siswa yang diperoleh dari pre-test dan hasil belajar siswa yang diperoleh dari hasil  post-test. Data analisis menggunakan statistik deskriptif, ANAKOVA, dan uji LSD. Hasil penelitian menunjukan, bahwa 1) skor rata-rata hasil belajar siswa yang belajar dengan model blended learning berkualifikasi baik (M = 84,00; SD = 6,39) dan siswa yang belajar dengan model pembelajaran konvensional (MPEEK) juga berkualifikasi baik (M = 80,08; SD = 6,24), dan 2) terdapat perbedaan yang signifikan hasil belajar siswa antara siswa yang belajar dengan model blended learning dan model konvensional (MPEEK) (F = 19,676; p<0,05) dan >LSD, sebesar(0,874>0,219).
 
Kata-kata kunci:   literasi sains, model pembelajaran blended learning, model pembelajaran konvensional (MPEEK), dan hasil belajar siswa
Liturgia Apokalipsy jako wyraz wiary Kościoła w Jezusa Chrystusa na podstawie Ap 4–5
Authors: Grajczyk Rafał
Published: July 2024

Przedmiotem badań jest analiza fragmentu Księgi Apokalipsy św. Jana 4,1–5,14. Chodzi o rolę liturgicznej narracji perykopy, próbującej ukazać specyfikę kultu chrześcijańskiego, jaką jest obecność osoby Jezusa Chrystusa i Jego paschalnego misterium. Badania zostały przeprowadzone metodami synchronicznymi.W celu dogłębnej analizy w punkcie 1 przedstawiony został kontekst historyczny i liturgiczny Apokalipsy św. Jana. Zbadano, jak apokaliptyczno-prorocki charakter pisma wiąże się z jego liturgiczną specyfiką. Następnie ukazano historyczne Sitz im Leben Księgi, aby przeanalizować jej liturgiczne źródła. W końcu podjęto zagadnienie liturgii jako jednej z głównych idei teologicznych Księgi.W punkcie 2., stosując metodę lingwistyczną, wykonano szczegółową analizą fragmentu Ap 4,1–5,14. Tekst poddano analizie syntaktycznej, celem ustalenia struktury jednostki. Następnie dzięki analizie semantycznej zbadano znaczenie słów i motywów. Ostatecznie stosując analizę pragmatyczną, przedstawiono intencje autora natchnionego i celowość użytych w perykopie motywów.W punkcie 3. w sposób systematyczny zostało podjęte przesłanie teologiczne tekstu w kontekście liturgicznego charakteru pisma. Wykorzystano syntezę wyników osiągniętych w 1. i 2. punkcie badań.Wniosek, jaki należy wyciągnąć jest taki, że badany tekst ukazuje istotę kultu chrześcijańskiego prezentowanego przez Apokalipsę, jakim jest chrystocentryzm i paschalność liturgii.
Relação entre doenças bucais e cognição em idosos
Authors: Souza Alice Borba de , Camboim Raissa Lossio , Rocha Lidianne Mércia Barbosa Malta , Araújo Érika Holanda de , Araújo Renata Silva de , Gaines Angelica Patricia León , Santos Ellen Karla Nobre dos
Published: July 2024

Objetivo: Realizar uma revisão integrativa sobre os efeitos de doenças bucais no comprometimento cognitivo em pessoas idosas, reunindo informações científicas sobre cognição na Odontogeriatria. Métodos: Foram pesquisados artigos científicos disponíveis na Biblioteca Virtual em Saúde (BVS). Os descritores utilizados foram “demência”, “disfunção oral”, “idosos” e “doença periodontal”, com a estratégia de busca demência AND disfunção oral AND idosos AND doença periodontal. Os filtros utilizados foram “texto completo” e “últimos 10 anos”. Resultados: Nos estudos analisados, pôde-se observar uma via de mão dupla na relação entre doenças bucais e o comprometimento cognitivo, ambos interligados pela inflamação crônica. É relevante explorar mais a relação entre saúde bucal e a cognição para que ocorra a prevenção ou a detecção precoce de fatores de risco para o comprometimento cognitivo, levando a uma abordagem integral do indivíduo idoso. Como perspectiva futura, estudos epidemiológicos na população brasileira poderiam ajudar a melhor esclarecer a relação aqui estudada. Considerações finais: Esta revisão integrativa avaliou a influência de disfunção oral, perda dentária e periodontite no comprometimento cognitivo em idosos. Os estudos sugerem que tais condições bucais têm impacto negativo na cognição em idosos.
A Bibliometric Study on Junctional Ectopic Tachycardia: Time and Trends have much to Tell!
Authors: Jose Jes , Magoon Rohan , Choudhary Nitin , Suresh Varun , Kumar Mukesh
Published: July 2024

Objectives:

Junctional ectopic tachycardia (JET), an arrhythmia of substantial clinical relevance, is no less than an eternal nemesis in cardiac critical care. Hence, we hereby present a bibliometric study evaluating the research trends in the subject.

Material and Methods:

A Scopus search-based bibliometric analysis of the keyword “Junctional Tachycardia” OR “Junctional Ectopic Tachycardia” restricted to original articles and reviews was undertaken after excluding the veterinary-related papers. The metadata thus obtained was analyzed using Scimago Graphica 1.0.42 and VOSviewer version 1.6.20 to generate a graphical representation of the trends and the timelines based on the author keywords.

Results:

A total of 926 papers of interest were identified and selected for the analysis, which revealed the geographical distribution of productivity being primarily concentrated in the Western developed nations, topic receptiveness largely appreciated in cardiovascular-related journals, and increased yearly output of the JET-associated papers. Further perusal identified 79 most frequently observed author keywords when limited to a minimum of 5 co-occurrences, which were grouped into seven color-coded clusters by VOSviewer, and mapped into keyword as well as author network, overlay, and density projections.

Conclusion:

Bibliometric analysis of JET papers from 1967 to 2024 shows a growing interest in the topic, awaiting newer insights into the molecular mechanisms and the preventative treatment strategies.
Non-granulomatous meningoencephalitis with Balamuthia mandrillaris mimicking a tumor: First confirmed case from Pakistan
Authors: Javed Zanib , Hussain Mustafa Mushtaq , Ghanchi Najia , Gilani Ahmed , Enam S. Ather
Published: July 2024

Background:

Free-living amoebae rarely instigate intracranial infections that may resemble neoplastic conditions on imaging. Naegleria fowleri precipitates an acute, swiftly fatal meningoencephalitis, whereas Acanthamoeba and Balamuthia species typically manifest with a less aggressive onset but carry equally dire consequences.

Case Description:

The case describes a 33-year-old woman with subacute encephalitis caused by Balamuthia mandrillaris. She experienced 2 months of back pain, 1 month of headaches, and 2 weeks of vomiting without fever, recent travel, aquatic activities, or animal exposure. Brain magnetic resonance imaging revealed a sizable, heterogeneous enhancing mass in the right temporal and frontal lobes, accompanied by vasogenic edema and midline shift. Histopathology showed marked inflammation and damage to blood vessels with amoebic trophozoites present. The trophozoites displayed specific characteristics, leading to the diagnosis of amoebic meningoencephalitis. Polymerase chain reaction and Sanger sequencing confirmed B. mandrillaris infection while testing for N. fowleri and Acanthamoeba was negative. Despite antibiotic treatment, the patient’s condition deteriorated rapidly, resulting in death within 2 weeks of presentation.

Conclusion:

This is the first confirmed case of B. mandrillaris central nervous system (CNS) infection from Pakistan. The incidence of this disease is expected to rise due to increasing temperatures due to climate change and the deteriorating quality of the water supply. Balamuthia meningoencephalitis should, therefore be on the differential for non-neoplastic CNS lesions. Furthermore, an atypical histopathologic picture, including the absence of granulomatous inflammation, needs to be recognized.
Synergetic Hybridization Strategy to Enhance the Dynamicity of Poorly Dynamic CO2-derived Vitrimers achieved by a Simple Copolymerization Approach
Authors: Seychal Guillem , Ximenis Marta , Lemaur Vincent , Grignard Bruno , Lazzaroni Roberto , Detrembleur Christophe , Sardon Haritz , Aranburu Nora , Raquez Jean-Marie
Published: July 2024

Copolymerization allows tuning polymer’s properties and a synergetic effect may be achieved for the resulting hybrid, i.e., outperforming the properties of its parents as often observed in natural materials. This synergetic concept is herein applied to enhance both dynamicity and properties of vitrimeric materials using poorly dynamic hydroxyurethane and non-dynamic epoxy thermosets. The latter generates activated hydroxyl, promoting exchange reactions 15 times faster than pure polyhydroxyurethanes. This strategy allows obtaining catalyst-free high-performance vitrimers from conventional epoxy-amine formulations and an easily scalable (bio-)CO2-based yet poorly efficient dynamic network. The resulting hybrid network exhibits modulus retention superior to 95% with fast relaxation (<10 min). The hydroxyurethane moieties actively participate in the network to enhance the properties of the hybrid. The material can be manufactured as any conventional epoxy formulation. This new strategy to design dynamic networks opens the door to large-scale circular high-performance structural carbon fiber composites (CFRP). The CFRP can be easily reshaped and welded from flat plates to complex geometries. The network is degradable under mild conditions, facilitating the recovery and re-use of high-added-value fibers. This accessible and cost-effective approach provides a versatile range of tunable dynamic epoxides, applicable across various industries with minimal adjustments to existing marketed products.
A bridged azobenzene derivative exhibits fully-reversible photocontrolled binding to a G-quadruplex DNA/duplex junction
Authors: Ramos-Soriano Javier , Jiang Y. Jennifer , Deng Bowen , O'Hagan Michael , Haldar Susanta , Grao Aditya , Oliveira Sofia , Mulholland Adrian , Galan M. Carmen
Published: July 2024

The ability to control G-quadruplex (G4) conformation using light as an external stimuli offers unique opportunities to control G4 in biological settings and for the development of nucleotide-based nanodevices. We describe a novel G4-binding chemotype derived from a cyclic azobenzene core that reversibly photoisomerises between E- and Z- under physiological conditions. We demonstrate the selective binding of the E-ligand towards LTR-III G4 and show that binding and dissociation from the LTR-III G4 can be controlled reversibly by alternate irradiation with blue and green light. Interestingly, the different isomers exhibit very distinct binding modes. Whilst the (E)-ligand preferentially binds at the G4/duplex junction of the LTR-III sequence, the (Z)-isomer favours the duplex region.
The influence of the crystal sponge framework on guest molecule conformation
Authors: Soper Eleanor , Coles Simon , Day Graeme
Published: July 2024

The crystalline sponge (CS) method has become an important technique for structural elucidation of compounds that are challenging to crystallise. However, the impact of the CS environment on guest molecule conformations has not been systematically studied. We present a computational investigation of the conformations of organic molecules of varying flexibility in a set of experimentally determined CS structures, comparing them to gas phase conformers and, where available, pure and co-crystal structures. Via solid state and molecular density functional theory calculations, we quantify the total relative energy, conformational energy, and intramolecular strain of guest molecules, as well as framework strain. Our results show that while CS structures induce some distortion in guest geometries (total relative energies up to 41 kJ/mol), they generally adopt low-energy conformations, often within 2 kJ/mol of the global energy minimum. Intramolecular strain in CS structures is often lower than in conventional crystal structures, suggesting a more neutral packing environment where molecules are closer to their favoured isolated-molecule geometries. We also observe that multiple guests can influence each other's geometries, even in the absence of direct guest-guest interactions. These findings provide a quantification of conformational distortion that can form the basis for interpreting molecular geometries obtained from CS structures.
Biosynthesis of Brevinic Acid from Lawsone
Authors: Hohmann Maximilian , Gulder Tobias
Published: July 2024

The menaquinone-pathway (men) is widespread in bacteria and key to the biosynthesis of intriguing small molecules such as the essential vitamin menaquinone and the natural dye lawsone. The violet molecule brevinic acid is another proposed product of men, but its direct biosynthetic precursor has remained doubtful. In this study, we isolated brevinic acid from E. coli and confirmed its non-enzymatic formation from lawsone and homocysteine involving an intermediate acetylation or phosphorylation step. We furthermore compared our proposed substrates in a non-enzymatic assay against the previously hypothesized precursor DHNA and showed that the reaction with activated lawsone derivatives proceeded faster, more selective, and with complete turnover. This supports our proposed biosynthesis of brevinic acid from lawsone and enables a cost effective, larger-scale synthesis of brevinic acid.
Graphene oxide variations in NiGraf during OER: structural dynamics of nickel-based electrocatalysts for enhanced water electrolysis
Authors: Caliandro Rocco , Berretti Enrico , Pagliaro Maria V. , Ciriminna Rosaria , Mangini Vincenzo , Giannini Cinzia , Lavacchi Alessandro , Pagliaro Mario
Published: July 2024

Alkaline water electrolysis, which relies on efficient and durable electrocatalysts made from earth-abundant metals like nickel for both hydrogen and oxygen evolution reactions, is a crucial energy storage technology for the transition to renewable energy. In operando techniques enabling the observation of active catalysts under relevant working conditions by monitoring the surface oxidation state and local atomic-structure transformation, can probe the active sites and promote fundamental understanding of the reaction mechanisms. In this study we present a new operando investigation of the electrocatalyst NiGraf by synchrotron X-ray Powder Diffraction and Pair Distribution Function. The structural changes in the crystal phases of this new metal organic alloy comprised of graphene oxide entrapped in nickel-based jamborite nanoparticles during voltammetry cycles in the OER range revealed a first reversible variation in the distance between GO planes during the reaction, and the subsequent reaching of the irreversible activation stage of the electrocatalyst. The technique, which couples Pair Distribution Function, Principal Component Analysis and operando electrochemistry is a new tool for the study of electrocatalysts in action.
Quantifying the distribution of proteins at the interface of oil-in-water food emulsions
Authors: Jabermoradi Abbas , van Duynhoven John , Hohlbein Johannes
Published: July 2024

Emulsifiers play an essential role in ensuring the physiochemical stability of food emulsions. In the case of mayonnaise, proteins contained in egg yolk act as emulsifiers. Here, we employed stochastic optical reconstruction microscopy (STORM) to localize proteins at the oil/water droplet interface using fluorescently labeled antibodies. To quantitatively analyze the distribution of proteins, we first simulated homogeneous and heterogeneous distributions. We then implemented the relative position distribution (RPD) analysis to extract the histogram of relative distances between all neighboring localizations. By analyzing the local maxima of the histogram, we could classify distributions at droplet interfaces as homogeneous, partially heterogeneous, and heterogeneous. The model fitting over the RPD histogram using a 2D probability function further provided a localization precision amplitude consistent with the analysis of the local maxima. As a model system for mayonnaise, we used emulsions prepared with combinations of phosvitin, phospholipids, apolipoprotein B (apoB), and sodium dodecyl sulfate (SDS) as emulsifiers. The binary phosvitin/SDS model emulsion showed a partially heterogeneous distribution of phosvitin around the droplets. The ternary phosvitin/phospholipid/SDS and apoB/phospholipid/SDS emulsions showed increased heterogeneity of phosvitin and apoB. Quantification of heterogeneity at droplet interfaces may provide insights in factors determining the physical and chemical stability of emulsions.
A new physical picture to achieve small singlet-triplet energy gaps in high-efficiency polycyclic heteroaromatic emitters
Authors: Walia Rajat , Xiong Xin , Fan Xiao‐Chun , Wang Kai , Shi Yi-Zhong , Tang Xun , Bredas Jean-Luc , Adachi Chihaya , Chen Xian-Kai , Zhang Xiao-Hong
Published: July 2024

The manipulation of the singlet-triplet energy gap (ΔES1T1) is an active area of research in the field of organic semiconductor materials. In polycyclic heteroaromatic emitters, which possess a great potential for application in ultra-high-definition displays, the origin of a small ΔES1T1 and its relationship with molecular structure still remain poorly established. Here, based on configuration-interaction theory, we derive a new effective expression for ΔES1T1, in which ΔES1T1 positively depends both on 2KHL (where KHL is the exchange energy between the HOMO and LUMO levels) and on the energy gap between the LUMO and LUMO+1 levels (ΔELUMO-LUMO+1). This physical picture of ΔES1T1 goes well beyond the simple HOMO→LUMO description that has been routinely applied in conventional donor-acceptor-type molecules and is validated over a series of more than sixty reported polycyclic heteroaromatic emitters. It allows us to suggest that an appropriate introduction of meta-substituted molecular fragments, which have small KHL and ΔELUMO-LUMO+1 values, is an effective way of designing molecules with smaller ΔES1T1. Importantly, a proof-of-concept molecule, IV-DABNA, was synthesized and demonstrates an extremely small ΔES1T1 (0.02 eV); its rate of reverse intersystem crossing is as fast as 4.4×106 s-1, the highest value reported in such systems. Sky-blue electroluminescent devices exploiting IV-DABNA as an emitter exhibit a remarkable maximum external quantum efficiency (EQE) of 32.1% with a largely suppressed roll-off (5.1%) at 1000 cd m-2. Overall, our work provides a new physical picture to reach a small ΔES1T1 in emerging polycyclic heteroaromatic emitters, which will accelerate the development of high-efficiency systems.
Letting Animals Off the Hook
Authors: Delon Nicolas
Published: July 2024

A growing literature argues that animals can act for moral reasons without being responsible. I argue that the literature often fails to maintain a clear distinction between moral behavior and moral agency, and I formulate a dilemma: either animals are less moral or they are more responsible than the literature suggests. If animals can respond to moral reasons, they are responsible according to an influential view of moral responsibility—Quality of Will. But if they are responsible, as some argue, costly implications must be acknowledged. If, however, they should not be considered responsible, then we may have to reassess the meaning of animal morality. I discuss ways to eschew responsibility or to tailor it to animals and argue that each requires a revised conception of animal morality.
The Person as Environmentally Integrated
Authors: Carter Matilda
Published: July 2024

While there are urgent health-related demands surrounding dementia, there are sociopolitical dimensions to this issue that ought not to be neglected, concerning the ways in which institutions and individuals treat people living with dementia. Key among these concerns, for dementia self-advocate Christine Bryden, is the dominant narrative of dementia as a process that irreversibly sets those that live with it on a path to the destruction of their personal identities and personhood. In this paper, I bolster Bryden’s arguments against the loss narrative and develop a novel conception of personhood as a first step towards challenging it.
Not Living My Best Life
Authors: Fletcher Guy
Published: July 2024

In a recent paper, Michal Masny put forward a novel, interesting, theory of the goodness of a life: the Dual Theory. As Masny’s discussion demonstrates, the Dual Theory, if true, would have very significant implications for various issues related to the goodness of lives and for normative ethics. It is thus worthy of serious attention. In this paper, I first explain the Dual Theory and the motivation Masny provides for it. I then aim to show three general problems for the view.
ANALISIS BENTUK KETERGANTUNGAN KOTA-KOTA KECIL DI SIKAWAN TERHADAP KOTA PEKANBARU
Authors: Palensa Yusri Ihza
Published: July 2024

Kawasan Pekansikawan sebagai kawasan metropolitan terdiri dari Pekanbaru, Siak, Kampar, dan Pelalawan. Pada kawasan Pekansikawan terdapat Kota Pekanbaru sebagai inti dan beberapa kota-kota kecil yaitu Kota Perawang (PKL Kabupaten Siak), Bangkinang (PKW Kabupaten Kampar), dan Kerinci (PKW Kabupaten Pelalawan). Perkembangan kota satelit akan sangat bergantung terhadap kota induknya sehingga ketergantungan kota kecil akan menyebabkan terjadinya perpindahan penduduk dari kota kecil menuju kota besar sehingga akan menimbulkan berbagai permasalahan di wilayah asal dan wilayah tujuan. Tujuan penelitian ini adalah mengidentifikasi bentuk ketergantungan kota kecil di Sikawan terhadap kota Pekanbaru. Penelitian ini menggunakan pendekatan penelitian deduktif kuantitatif dan kualitatif, dengan teknik analisis deskriptif kualitatif dan deskriptif kuantitatif menggunakan scoring. Hasil penelitian menemukan bahwa bentuk ketergantungan Kota Kecil di Sikawan terhadap Kota Pekanbaru berupa ketergantungan satu arah (Non feedback dependent) terhadap kesehatan tingkat lanjut, pendidikan tinggi, industri konstruksi, dan sektor otomotif di Kota Pekanbaru. Faktor penyebab ketergantungan ini adalah sarana prasarana, semakin lengkap dan baik sarana prasarana kota kecil akan semakin mengurangi ketergantungan kota. Aksesibilitas, semakin dekat jarak dan mudahnya akses kota kecil ke kota besar akan semakin tinggi ketergantungan kota kecil. Kondisi ekonomi, semakin baik kondisi ekonomi kota kecil maka akan semakin mandiri dan mengurangi ketergantungan terhadap kota besar.

 

Kata Kunci : Ketergantungan; Metropolitan; Satelit