bluuebunny/crossref_metadata_2025 huggingface dataset:
Fintech’s Impact on the Digital Transformation of the Qatar Insurance Sector: Opportunities and Challenges
Authors: Elomari Raed
Published: December 2024

This study provides a comprehensive analysis of Qatar’s digital insurance industry using a conceptual framework based on established theories. The study aimed to assess different challenges and opportunities, including the regulatory environment, market dynamics, competitive strategies, and digital payment and financial inclusion in Qatar, and also fill a critical gap in the literature. The study uses a positivist perspective and deductive methodology to explore Qatar’s digital insurance sector, revealing diverse demographics and strong correlations between variables like regulations and competitive rivalry, highlighting the positive attitude towards digitization in the industry. The regression model, elucidating 61.7% of the variance, accentuates the pivotal role of “Competitive Rivalry and Enhanced Digital Insurance Sector.” Nevertheless, non-significant contributions from “Security Challenges for Digitization” and “Market Competitiveness” beckon further exploration. The study concludes with insightful recommendations for transparency enhancements, digital tool exploration, and addressing new entrant barriers, offering invaluable guidance to industry stakeholders navigating Qatar’s dynamic digital insurance landscape.
Cloud Security Challenges and Solutions: A Review of Current Best Practices
Authors: Akinade Afees Olanrewaju , Adepoju Peter Adeyemo , Ige Adebimpe Bolatito , Afolabi Adeoye Idowu
Published: December 2024

This review provides an overview of the challenges and solutions in the realm of cloud security, offering insights into current best practices to mitigate risks associated with cloud-based services. As organizations increasingly transition their operations to the cloud, ensuring robust security measures becomes imperative to protect sensitive data and maintain the integrity of digital assets. The review begins by addressing the key challenges that organizations face in cloud security. These challenges include data breaches, unauthorized access, compliance issues, and the dynamic nature of cloud environments. Understanding these challenges is crucial for developing effective security strategies. Subsequently, the review explores current best practices and solutions to enhance cloud security. It delves into encryption techniques, identity and access management (IAM) protocols, and multifactor authentication as essential components of a comprehensive security posture. Additionally, the review discusses the significance of regular security audits, threat intelligence, and proactive monitoring to detect and respond to potential threats promptly. The role of cloud service providers in ensuring security is also scrutinized. The review emphasizes the importance of selecting reputable and compliant providers, understanding shared responsibility models, and leveraging native security features provided by cloud platforms. Furthermore, the review examines the evolving landscape of compliance standards and regulations governing cloud security. It highlights the necessity for organizations to stay abreast of industry-specific compliance requirements and adopt frameworks such as ISO 27001 and SOC 2 to fortify their security practices. Ultimately, the review concludes by emphasizing the dynamic nature of cloud security and the need for continuous adaptation to emerging threats. It underscores the importance of fostering a security-centric culture within organizations, involving stakeholders at all levels, and investing in employee training programs. In summary, this review provides a comprehensive examination of cloud security challenges and offers practical insights into current best practices. It serves as a valuable resource for organizations navigating the complexities of cloud security, guiding them towards effective risk mitigation and safeguarding their digital assets in an increasingly interconnected and cloud-dependent landscape.
The "Five Forces Model" and strategies for enhancing the influence of scientific journals
Authors: Liang Yongxia , Yang Zhongkai , Tian Hong , Liu Jingjing , Li Cuixia , Dong Wenjie
Published: December 2024

Background: Based on relevant theory of science of science, we aimed to construct a model for evaluating the influence of science journals and thereby propose strategies to enhance their impact. Methods: By using methods such as a literature review, in-depth interviews, and a concept analysis, we considered various aspects related to science journals, including knowledge production, flow, and dissemination, and developed what we call the "Five Forces Model, " along with countermeasures and suggestions. Results: We identified knowledge power, persuasiveness, management power, expressiveness, and dissemination power as the five aspects that determine the influence of science journals. The Five Forces Model was built using these five aspects. Conclusion: Influence development and enhancement are integrated processes among science journals. Theories on knowledge activities need to be utilized effectively to improve a journal's knowledge power. Paradigm theories need to be understood to increase a journal's persuasive ability. The Matthew effect within the scientific community should be given attention to strengthen managerial capacity. Further, the advantages of structural holes should be leveraged for a journal to showcase its expressive capability. Fully recognizing the functions of science journals can help reinforce their dissemination capabilities.
University of Wisconsin-Madison mechanical engineering experiential design project case study
Authors: Zhang Xiujuan Jane , Jiang Changyang Thomas , Sun Jingxi , Cheadle Michael
Published: December 2024

This case study explores the experiential learning course of Interdisciplinary Experiential Design Projects (ME 351/352) within the Mechanical Engineering Department at the University of Wisconsin-Madison. Central to the engineering curriculum, this two-semester capstone sequence integrates human-centered design principles and hands-on learning to bridge academic knowledge with real-world applications. Students carry out client-driven projects, developing technical, communication, and project management skills through iterative design, prototyping, and testing. With active collaboration from faculty, industry sponsors, and peers, the course prepares students for the workforce by addressing the "skills gap" between academic training and industrial demands. Key features include a structured yet flexible course design, stakeholders' analysis, dedicated design spaces, and weekly feedback mechanisms, fostering technical innovation, professional growth, and industry engagement. This study highlights the experiential learning course's value in enhancing student employability while providing industry partners with recruitment opportunities and innovative solutions, it also points out certain challenges and corresponding action plan for continuous course improvement.
Science or industry: Improving the quality of the Russian higher education system
Authors: Panova Anna , Slepykh Victoria
Published: December 2024

The shape of the modern Russian science and higher education system is largely determined by the peculiarities of its structure during the Soviet period: its division into research and higher education sectors. However, throughout the 21st century, the higher education system has undergone significant reforms. An important focus of these reforms has been the development of the research mission of higher education institutions (HEIs). At the same time, the government launched reforms that focused on the development of regional markets, where universities were an important driver of this development, and on the interaction of universities with local employers. There have also been reforms aimed at changing the system to determine the number of state-funded places and places for targeted enrolment and how they are distributed between universities. All these reforms have changed the functioning of universities. In this study, we describe the current landscape of the Russian higher education system, and how different types of universities are involved in research, attracting more talented students and engaging with other sectors of the economy.
Study of vocational training programs themed on "women's empowerment" in Japan
Authors: Qin Yizhen , Huang Futao
Published: December 2024

This study examines vocational training programs in Japan centered on "women's empowerment" and their role in facilitating women's re-entry into the workforce after career breaks. In Japan, many women leave the workforce for caregiving responsibilities, contributing to the "M-shaped curve" in labor force participation. Although recurrent education and reskilling opportunities are increasing, challenges remain, including limited program flexibility, financial constraints, and misalignment with labor market needs. The study analyzes these challenges through text mining and interviews, highlighting the need for modular and flexible learning options, targeted financial support, and better alignment of training programs with high-demand industries. The findings emphasize the importance of comprehensive support systems, such as mentorship and childcare services, to improve program accessibility. Addressing these barriers can enable women to successfully re-enter the job market, matching their qualifications with employment opportunities. The study concludes with policy recommendations aimed at improving the effectiveness of vocational training programs to support women's long-term career development in Japan.
Value of technical and vocational higher education in the labor market: Comparative perspectives from Middle Eastern countries
Authors: Uslu Baris
Published: December 2024

The Middle East is a geopolitically diverse region that includes large economies, such as Saudi Arabia and Türkiye; densely populated countries, such as Iran and Egypt; and smaller nations with a high gross domestic product (GDP) per capita, such as the United Arab Emirates and Qatar. Despite the differences in sociocultural, economic, and environmental contexts between these countries, individuals across the region must participate in the labor force and contribute to production to benefit from national wealth. Specialized technical skills offer a significant advantage in securing employment, and technical and vocational education and training (TVET) in higher education has become a viable pathway for various technical roles. On this point, through its varying national (e.g., population, GDP, GDP per capita, human development level, TVET starting age, TVET enrollment in higher education, gross enrollment in higher education) and TVET-related factors (quality of TVET, labor participation by TVET graduates, salary for TVET graduates, unemployment rate for TVET graduates), the Middle East presents an interesting case for examining the value of TVET in higher education to the labor market. Accordingly, this study aimed to compare the advantages (or disadvantages) of TVET graduation for people to access the labor market in Middle Eastern countries. The research was designed as a comparative quantitative study, following a descriptive survey model. The comparative analysis included data from Egypt, Iran, Qatar, Saudi Arabia, Türkiye, and the United Arab Emirates to compare TVET in higher education and employment relations. National data for the selected countries were collected from various sources. The focus was on statistical comparisons using cross-tables and classification and regression tree analysis. The analysis showed that TVET is a good way to secure work in the case countries (with relatively lower unemployment for TVET graduates). Nonetheless, according to a comparison of national data, GDP emerged as the most significant factor, highlighting the demand for more professionals in larger-scale production within the related countries. The results also reveal that the TVET starting age and gross enrollment in higher education are among the influential factors for students choosing TVET programs in higher education (ISCED level 5), while TVET-related factors do not generate a distinction in terms of the number of students who prefer TVET programs at the higher education level. Potential policy developments and practices are also discussed concerning educational priorities in Middle Eastern countries to increase the attractiveness of the TVET system as well as its value to the labor market.
Real Time Flight Tracking Using Deep Learning and Blockchain Technology
Authors:   Department of Computer Science                     RMK Engineering College                 Chennai, India, Mounika K. Lakshmi , S    Dr. Selvi , Sethukarasi      Dr. T.
Published: December 2024

This paper presents the design and        implementation of a 3D Real-Time Flight Tracking and continues Updates System, incorporating deep learning and block-chain technology, aimed at providing live updates on flight status, delays, and cancellations. The system also sends automated notifications via SMS or email for flight status changes. By leveraging advanced technologies, the system ensures data integrity, security and scalability, making it suitable for the aviation industry’s future needs. The aviation industry relies heavily on accurate and timely flight tracking for safety and operational efficiency. Traditional Systems, while effective, often lack predictive capabilities and robust data security measures. This paper proposes a novel approach that integrates deep learning algorithms for secure and immutable data logging. By leveraging Automatic Dependent Surveillance-Broadcast (ADS-B) data, Our system enhances real-time flight tracking with higher accuracy and reliability. We present a comprehensive system development and testing framework, demonstrating the effectiveness of our approach in a simulated environment. solution for real-time flight tracking and updates.

The innovative aspects of this system include the use of deep learning algorithms for accurate prediction of flight delays and cancellations based on real-time data from multiple sources, such as weather conditions, air traffic, and historical flight data. Block-chain technology is utilized to create a decentralized and tamper- proof ledger for recording flight data, ensuring the integrity and security of information shared among stakeholders, including airlines, airports. And   passengers.

Keywords ~ Real-time flight tracking, deep learning, block-chain, automated notifications, aviation technology, predictive analytics.
Implementation of Machine Learning – Based Fowl Disease Detection Using CNN
Authors:   Assistant Professor, Visvesvaraya Technological University, Computer Science, SJB Institute of Technology,  Bangalore, Karnataka, India, M Anusha , Sagar S Koushik , V Lokesh , Gowda TL Jaishankar , Dileep Jadepalli Muni
Published: December 2024

Poultry husbandry is an essential contributor to global food security, yet it faces significant challenges from complaint outbreaks, leading to profitable losses and high mortality rates. This paper presents an automated funk complaint dis- covery Model using CNNs - Convolutional Neural Networks. By using image bracket ways, the sys- tem classifies fecal images into complaint orders similar as Newcastle complaint, coccidiosis, and healthy. The proposed result achieves high delicacy and scalability, offering growers a dependable tool for early complaint discovery and intervention. Experimental results demonstrate the effectiveness of models like VGG16, EfficientNetB5, and MobileNetV3, with EfficientNetB5 achieving superior performance

Keywords: Convolutional Neural Networks, Poultry variety diseases,VGG16 Layer ML model, and MobileNetV3 ML model, EfficientNetB5, Deep Learning.
Brain Tumor Detection and Classification using Machine Learning Models
Authors:   Assistant Professor  Dept of Electronics and Communication Engineering, Humse Kiran Kumar , A Sanjana , H P Shashank , K Vaishnavi , M Vinay
Published: December 2024

Tumor of the brain is one of the most severe pathological identification. whose patients depend on early detection and enough treatment. Consequently, in the current practice, it is common to obtain MRI scans accompanied by assessment by radiologists could become boring and could contain mistake. Presently, with the help of ML and the recent pioneering findings in the imaging. techniques there is a tremendous chance of enhancing the enhancement of the speed and accuracy of detection of brain tumours. This work uses a dataset obtained from Kaggle to contain images of healthy TCs from healthy brains, brains with tumors and also applies a MobileNetV2 deep But in case of online learning, the model to be used is a polymer of CNN learning model to act as an automated. detection. Google Colab is used for computation while Gradio for explaining the results of the model trained. used for implementing the userinteractive interface through where users can enter scans of their brain to get the predictions from. The intent of the system in this approach is to present a sensible and easy-to-use telecommunication friendly system that can effectively early screen for AD. brain tumors.

Keywords
Neuro-oncology, Screening, Gradio, MobileNetV2, Google Colab,Deep Learning Models,Convolutional Neural Networks(CNN).
Economic and Social Impact of Indian Rural Road Program
Authors:   1Semester III, M. Arch., School Of Architecture, IPS Academy, Indore, Vyas Amber
Published: December 2024

Rural roads are key component of rural development. They affect the rural population in various ways.. It eases the accessibility of the rural population to essential services like education and healthcare. Development of rural roads has significant social and economic impact. Rural roads enhance connectivity, foster economic growth and improve the quality of life in the rural communities. Even with the better connectivity, the remote areas still lag in economic development.

            This paper covers the various social and economic impacts of the Pradhan Mantri Gramin Sadak Yojana (PMGSY) both anticipated and unanticipated by the policy makers. There have been many changes attributed to the development of all-weather rural roads but are not consistent with the predictions and goals.

Key Words:   Rural roads, Economic Impact, Social Impact, Land Value, Rural Economics.
A study on the effectiveness of a participatory self-care model for homebound older adults in Khueang Nai District, Ubon Ratchathani Province, Thailand
Authors:   Sirindhorn College of Public Health Suphanburi Province, Faculty of Public Health and Allied Health Sciences, Praboromarajchanok Institute, Nonthaburi, Thailand, thongaram nopadol , Somporn Kanokporn ,   Department of Community Public Health, College of Allied Health Sciences, Suan Sunandha Rajabhat University, Bangkok, Thailand, Chusak Thassaporn ,   Faculty of Public Health, Valaya Alongkorn Rajabhat University under The Royal Patronage, Pathum Thani, Thailand, Surirak Sutthisak ,   Sirindhorn College of Public Health Suphanburi Province, Faculty of Public Health and Allied Health Sciences, Praboromarajchanok Institute, Nonthaburi, Thailand
Published: December 2024

Thailand is undergoing a structural social transformation into a complete aging society. This study aimed to investigate the effectiveness of a participatory self-care model for homebound older adults in Khueang Nai District, Ubon Ratchathani Province, Thailand. Given the rapid growth of the older adult population, Thailand faces significant challenges in fostering a quality aging society. Promoting self-care abilities among older adults can mitigate frailty and enhance their quality of life. The study employed a cross-sectional design and a randomized controlled trial (RCT) with pre-post test measurements. The sample comprised 64 homebound older adults aged 60 years and above, divided into an experimental group (n=32) and a control group (n=32). Data were collected through a questionnaire assessing general information, self-care knowledge, health-promoting behaviors, and activities of daily living (ADL). Descriptive statistics and analytical tests (Independent t-test and Paired t-test) were utilized for data analysis. The results indicated that after the four-month implementation of the developed participatory self-care model, the experimental group demonstrated significantly higher mean scores in knowledge, health-promoting behaviors, and ADL compared to the control group (p<0.05). Additionally, the experimental group exhibited significantly lower mean blood pressure and blood sugar levels (p<0.05). However, there was no significant difference in body mass index (BMI) between the groups. These findings suggest that the developed participatory self-care model can effectively enhance health knowledge, behaviors, and daily living abilities while helping to control risk factors for chronic diseases in homebound older adults. This model has the potential to be expanded and applied to older adults’ care in other areas to promote their quality of life and well-being.
1920’DEN GÜNÜMÜZE MİLLÎ EĞİTİM BAKANLARININ MESLEKLERİ BAĞLAMINDA BİR ANALİZİ
Authors: Oflar Yakup , Arıca Tufan , Gün Celal
Published: December 2024

Eğitim insanların dolayısıyla ülkelerin geleceğini şekillendirmede önemli etkenlerden birisidir. Bu sebeple bir sistem olarak eğitimin en iyi şekilde yönetilmesi gerekir. Özellikle formal eğitim öğretmenler eliyle okullarda verilmektedir. Ülkemizde birçok ülkede olduğu gibi eğitim faaliyetleri Millî Eğitim Bakanlığı eliyle yürütülmektedir. Bu çalışmada, Türkiye Büyük Millet Meclisinin açıldığı 1920’den günümüze Millî Eğitim Bakanları görev süreleri ve meslekleri dikkate alınarak analizinin yapılmasıdır. Bu analiz yapılırken süreç içerisinde 1920’den günümüze Türk Eğitim sistemi içerisinde yapılmış olan önemli değişimler, gelişmeler ve çalışmalar da dikkate alınmıştır. Çalışmada betimsel tarama yöntemi kullanılmıştır. Bunun için TBMM Albümleri, Türk Parlamento Tarihi kitapları, eğitim istatistikleri, TBMM zabıt cerideleri gibi ilgili kaynaklar taranmıştır. Çalışmanın sonunda 1920’den günümüze 81 kez Millî Eğitim Bakanlığı atamasının yapıldığı görülmüştür. Bu 81 atama içerisinde 67 farklı Millî Eğitim Bakanı görev yapmıştır. Bu bakanların 34’ü eğitim kökenlidir (öğretmen, akademisyen). İkinci sırası 19 bakanlık görevi ile hukukçular (avukat, hâkim, savcı) almaktadır. Bunların yanında asker, mühendis gibi farklı mesleklerden bakanlar da görev yapmıştır. Çalışmanın 1920’den günümüze Millî eğitim bakanlarının mesleklerini, bakanlık süreleri ve yapılan çalışmalar bakımından ortaya koyması önemlidir. Araştırma sonucunda, bir bakana ortalama 15 ay gibi kısa bir yürütme süresinin düştüğü görülmektedir. Bu sürenin, ilgili bakanlığın istikrarlı bir biçimde yürütülmesi açısından yeterli olmadığı düşünülmektedir.
DOKU MÜHENDİSLİĞİ İÇİN İNSAN PLASENTAL KORYONUNDAN GELİŞTİRİLEN PLURİPOTENT HÜCRELERİN UYGULAMALARI
Authors: Çataltepe Sude Naz , Karabul Nigar Sahra , Kırbayır Yağmur , Bashir Hatice , Saraçoğlu Pelin , Ihlamur Murat
Published: December 2024

Yaşamın erken dönemlerinde ve büyüme sırasında vücutta çok çeşitli hücre tiplerine dönüşebilen ve kendini yenileme konusunda muazzam bir yeteneğe sahip olan kök hücreler son yıllarda yoğun bir şekilde araştırılmıştır. Kök hücreler, insanlarda hasarlı veya hastalıklı organları yenileyebilen ve onarabilen özel hücrelerdir. Kök hücreler rejeneratif tıp ve doku mühendisliği için kullanılır. Bu nedenle, birçok rahatsızlığın ve hatalı dokunun tedavisinde faydalı sonuçlar gözlemlenir. Fetal ve yetişkin dokulardan izole edilen mezenkimal kök/stromal hücre hatları (kısaca MSC'ler), göç etme, yenilenme ve yaralı bölgeleri onarma yetenekleri sayesinde doku mühendisliği ve hücre terapötiklerinde kullanım için önemli ilgi görmektedir. Bu inceleme çalışmasında, doku mühendisliği teknolojilerini ilerletmek ve çeşitli rahatsızlıklara yönelik terapötik yaklaşımları araştırmak için insan plasenta koryonundan indüklenmiş pluripotent hücreler türetilmiştir.
Burdur'da çoban seslenmesi
Authors: Keyik Bayar Yağmur
Published: December 2024

Konargöçer toplum yapısı doğrultusunda Türklerin ekonomik anlayışlarının önemli ölçüde hayvancılığa dayandığı söylenebilir. Hayvancılığa dayalı ekonomi ise sürüleri sevk ve idare etme noktasında yetkin bireylerin varlığını zorunlu kılmış ve çobanlık önemli bir meslek alanı olarak karşımıza çıkmıştır. Değişen sosyal ve kültürel koşullara bağı olarak Türk toplumunda çobanlığa dair algı ikili bir yapı izlemiştir. Çalışma sahamız olan Burdur’un özellikle kırsal kesimlerinde hayvancılık önemli bir faaliyet olmuştur. Ekonomik faaliyet alanlarının gelişmesi ve özellikle genç nüfusun kent merkezine yerleşme düşüncesi hayvancılığa verilen önemi bir nebze de olsa azaltmıştır. Çobanlığın sürdürülebilmesi adına gereken çırak sayısının azlığı ise ayrı bir tehlike olarak görülmüştür. Bahsi geçen olumsuz durumlara karşın yörede bulunan çobanların zengin bir geleneksel bilgiye sahip olduğu ve bu geleneksel bilginin bir kısmının ise “çoban seslenmeleri”nden oluştuğu görülmektedir. Yapılan çalışmada çoban ve hayvanlar arasındaki iletişimin sağlanması ve süreklilik kazanması adına çobanlar tarafından farklı yaklaşımların benimsendiği görülmüştür. Çobanlar; çoban köpeklerini kullanarak, ıslık çalarak ve birtakım özel seslenmelerde bulunarak hayvanları sevk ve idare etmiştir. Bu özel seslenmeler aracılığıyla hayvanların bir araya gelmeleri, dağılmaları, su içmeleri gibi amaçların güdüldüğü görülmüş ve bu seslenmeler birtakım örnekler aracılığıyla sunulmuştur.
Infrastructure and Economic Growth: Panel Analysis of Selected Asian Countries
Authors: Hasan Mahmood ul , Muhammad Imran Hassan  , Saif Ullah  , Muhammad Nauman Malik
Published: December 2024

Effective and reliable infrastructure is considered helpful for economic growth. Particularly, transport infrastructure is an important factor in the development of countries. The infrastructure can be classified into different dimensions i.e. economic and social infrastructure. The current study uses panel analysis techniques to examine the association between infrastructure and economic growth. The panel data is used having a period from 2000-2020 for selected Asian countries. Panel unit root tests are applied to check the stationarity of the data, and findings depict that all variables are stationary at the first difference. After analyzing the unit root properties, the Pedroni cointegration technique is employed to assess the long-run association. The results indicate that all variables have an association in the long run. Furthermore, the Random effect model is employed for empirical investigations. The results concluded that transport infrastructure, energy use, and communication infrastructures positively affect the economic growth in the selected Asian countries. It is recommended that the government stress public expenditure to ensure effective infrastructure, promoting economic growth. It is also suggested that more budget may be consumed to make the roads, dams, telecommunication services, and bridges.
Exploring the Strategies to Combat Antimicrobial Resistance in ESKAPE Pathogens; A Comprehensive Review
Authors: Badar Laraib , Ibrahim Ahsan
Published: December 2024

Antimicrobial resistance is a huge challenge for the global health system, bringing about massive mortalities throughout the world. On the landscape of infectious diseases, the ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) organisms have emerged as grave threats, leading to millions of life-threatening infections. These pathogens have developed numerous mechanisms of resistance against conventional antibiotic agents such as penicillins, cephalosporins, glycopeptides, etc. The prospective research is pursuing novel methodologies for combating antimicrobial resistance in ESKAPE bacteria. This review depicts strategies other than conventional antibiotic agents to tackle the rising tendencies of antimicrobial resistance in ESKAPE pathogens. Many in vitro and in vivo studies have established the effectiveness of phage therapy and endolysins in countering the dominance of ESKAPE pathogens. Antimicrobial peptides, photodynamic therapy with mesoporous nanoparticles, and some other strategies have also demonstrated their potency to kill ESKAPE bacteria. Despite their fruitfulness, many challenges and limitations are also associated with these approaches. This review aims to summarize the progress and advancement in countering the antimicrobial resistance in ESKAPE pathogens. This review also recommends conducting further research to better understand the technicalities of these strategies and to further refine them to compose these methods as promising options for antimicrobial therapy against ESKAPE pathogens.
Exploration of antimicrobial activity and antioxidant potential of Loranthus Cordifolius plants from Mirpur Azad Kashmir, Pakistan
Authors: Mazhar Muhammad Waqas , Ishtiaq Muhammad , Maqbool Mehwish , Mazher Mubsher , Mushtaq Waheeda , Shahid Adnan , Faisal Iqbal Jafri  , Tanveer Hussain
Published: December 2024

Loranthus cordifolius is a parasitic plant, and its extracts are traditionally used in some cultures as antimicrobial and immunological medicines. Literature suggests that bioactive compounds produced by a parasitic plant could potentially be influenced by the host plant's own chemical composition, playing a role in the adaptogenic properties of the parasitic plant. In the present research, L. cordifolius shrubs were collected from host species Phyllanthus emblica and Juglans regia, and extracts were obtained using chloroform, petroleum ether, methanol, and water. The phytochemical profile, encompassing alkaloids, flavonoids, cardiac glycosides, tannins, terpenoids, and saponins, was qualitatively and quantitatively assessed, revealing varying concentrations based on solvents and hosts. Leaf extracts from L. cordifolius (Host P. emblica) displayed superior antifungal and antibacterial activities compared to those from L. cordifolius (Host J. regia). Notably, leaf extracts from L. cordifolius (Host P. emblica) exhibited effective results, including minimum inhibitory effect, Minimum Bactericidal Concentration, and Minimum Fungicidal Concentration. The leaf extracts of L. cordifolius (Host P. emblica) produced the best activity indices of 0.97, 0.97, 1.02, and 0.85 against the test organisms E. coli, S. aureus, P. aeruginosa, and B. subtilis, respectively, as compared to leaf extracts of L. cordifolius (Host J. regia) with values of 0.95, 0.95, 0.94, and 0.82 Stem extracts from L. cordifolius plants (Host P. emblica) demonstrated higher DPPH scavenging effect, total antioxidant activity, and total phenolic contents. These findings suggest that leaf extracts, particularly from host P. emblica, show promise as potential sources of green medicine due to their notable antimicrobial and antioxidant properties compared to the L. cordifolius plants from the host J. regia.
Bhilawanol ameliorates morphine condition place preference and anxiety-like symptoms during the abstinence period
Authors: Muskan Ameena
Published: December 2024

Opioid addiction is accompanied by persistent drug seeking and a high relapse rate even during prolonged periods of abstinence. The main objective of addiction treatment is to prevent relapse, which remains the primary limitation of the current pharmacological therapy. In the present work, the role of Bhilawanol (BWL), a naturally occurring compound, on morphine (MOR) condition place preference (CPP) and the anxiety-like behavior during the abstinence period in the mice model was investigated. MOR-CPP was induced with an increasing dose of intraperitoneal (i.p.) MOR 5 mg/kg bid to 25 mg/kg bid for 5 days during the conditioning schedule. The pharmacological effects of BWL (0.25, 0.5, and 1 mg/kg i.p.), were tested on the rewarding effects of MOR. BWL 1 mg/kg significantly reduced MOR acquisition and reinstatement, while accelerated extinction to MOR CPP. The anxiety-like behavior on the last extinction day was also markedly reduced with BWL 1 mg/kg as evaluated by the Open-field (OF) and elevated plus maze (EPM) test. The antioxidant assay showed that BWL significantly preserved the protective activity of the enzymes Glutathione-S-Transferase (GST), reduced glutathione (GSH), and catalase (CAT), and reduced the lipid peroxidation (LPO) in both the cortex and hippocampus regions of the brain. The immunohistochemistry revealed the protective effect of BWL on the expression of TNF-α, p-NF-κB, iNOS, and nNOS in both cortex and hippocampus regions of the brain. Further, BWL also modulated the expression of the TNF-α and BDNF in MOR-treated mice as measured through ELISA. In addition, the BWL displayed a significant reduction in the mRNA expression of iNOS and nNOS genes in the hippocampal region of the mice brain. These findings show the beneficial effects of BWL in MOR CPP, extinction, and reinstatement, as well as reducing anxiety during abstinence to MOR through modulation of antioxidant, inflammatory, and NO pathways.
Biomaterials in Regenerative Therapy for Cardiovascular Diseases: A Review
Authors: Arshad Mahdia , Niazi Samia Gul , Shaheen Shahida , Javed Chanda , Ain Qurat ul , Ajmal Mahnoor , Arshad Esha , Taimoor Muhammad
Published: December 2024

Loss of cardiac function is caused by the physical damage that a cardiovascular disease inflicts on the heart. While medications can help reduce symptoms, treating the underlying cause of an injury by repairing damaged tissues will benefit patients more in the long run. Cardiovascular surgeons use various techniques, in addition to heart transplants, to repair damaged heart tissue, including the ventricular septal wall and valves. Damaged cardiac tissues are replaced and repaired using a wide range of biomaterials. The two primary types of biomaterials are natural and synthetic. Metals and polymers are among other examples of synthetic materials used in cardiovascular applications. Natural materials come from biological sources, including tissues taken from animals or donated by humans. To maximize the prospects and reduce the negative aspects of both synthetic and natural materials, a new class of composite materials has emerged. These materials give a variety of new and better options for a permanent or a more persistent cure for cardiac diseases. The present and future uses of biomaterials in cardiovascular therapy are reviewed in this article. This study is done to further elaborate and highlight the uses of different materials in regenerative therapy. Its main objective is to focus on commonly used biomaterials and to compare them in different parameters. Regenerative therapy is the future of modern medicine and many new methods are being studied daily for advancement in regenerative therapy. This study focuses on different cardiac diseases and how different materials as a medium of regenerative therapy improve these conditions.
Treatment Response to Sertraline in the Pakistani Population and its Association with Cytochrome P450 2C19 Genotypes
Authors: Zarghuna Khan Hareem , Sadiq Zafar , Khan Imran , Ali Muhammad
Published: December 2024

Selective serotonin reuptake inhibitors (SSRIs) are metabolized differently depending on variations in the CYP2C19 gene. Clinical practitioners are using pharmacogenetic information based on the impact of CYP2C19 polymorphisms more frequently. Yet, the fundamental tenets connecting distinct metabolism to efficacy or adverse drug reactions are still poorly understood. This research was conducted in the hopes of establishing a link between genetic variants of the CYP2C19 gene and the therapeutic effect and adverse effects of the antidepressant Sertraline. The objective of this study was to determine the CYP2C19*2, *3, and *17 allele and genotype frequencies among the treatment-responsive and resistant patients and their correlation with the response and to determine the association of CYP2C19 allele to adverse effects of sertraline in major depressive disorder (MDD) patients. The study was conducted at the Institute of Pharmaceutical Sciences, Khyber Medical University. Fifty patients of MDD were recruited from a psychiatric clinic to take part in this study. Three scales, Hamilton Depression Rating Scale (HDRS or HAMD-17), General Medication Adherence Scale (GMAS),  and Liverpool University Neuroleptic Side Effect Rating Scale (LUNSERS) were used to assess depression severity, adherence to drug therapy, and adverse effects respectively at baseline and then at weeks 2, 4, 6 and finally at 6 months. 3ml blood was also taken from patients for genotyping polymorphic variants of CYP2C19. We found that the risk factors for depression as indicated by our study are females (58%) OR 1.18 as compared to males OR 0.75, married individuals (74%), and poor socioeconomic status (40%). A high response rate to sertraline was recorded with 82% responders and only 18% non-responders. Response rate of males was slightly higher than females at 92% and 90% respectively. HAMD 1st follow-up was significantly correlated to baseline score at p-value 0.01. GMAS was negatively correlated to HAMD with an R-value of -0.042. We found no significant association between CYP2C19 genotypes and sertraline therapeutic response or adverse effects. However, the study showed that adherence to drug therapy leads to better treatment response.
ASSOCIATION OF CYP2D6 GENE POLYMORPHISMWITH FLUOXETINE INDUCED ADVERSE REACTIONSIN PATIENTS WITH MAJOR DEPRESSION
Authors: Haq Inzemam
Published: December 2024

This study rigorously explores the intricate relationship between geneticpolymorphisms within the CYP2D6 gene, and the manifestation of adverse drug reactions induced by fluoxetine in individuals diagnosed with MDD. MDD represents a debilitating and challenging condition with a multifaceted etiology, encompassing genetic predisposition as a contributing factor. Nevertheless, a frequently recommended antidepressant that is the response to fluoxetine differs notably amongpeople. This variability results in the attribution to genetic variations in the gene encoding an enzyme CYP2D6 that is essential for the metabolism of fluoxetine. In this study, we intend to delve into the connection among CYP2D6 gene polymorphisms and adverse drug reactions to fluoxetine as well as evaluate the effect on productiveness of fluoxetine in MDD, and to inquire into their impact on the antidepressant effect of fluoxetine. The study also shows that there is polymorphic CYP2D6 alleles that is connected to an elevated probability of adverse drug reactionsto the fluoxetine, lessening the treatment productiveness, and low enhancement in the depressive symptoms. So, to address this issue the study delves into a sample of MDD patients, encompassing the clinical scales, and genetic testing to evaluate the role of CYP2D6 gene variations in fluoxetine response. The outcomes of this research arewide-ranging. This study also contributes to the evolving field of pharmacogenomics in psychiatry that facilitates the personalized treatment methods for MDD patients. Adverse reactions can be reduced, productivity can be increased, and patient safety can be improved by changing medication choices and doses based on geneticinformation. So, this research thus inquiries into enhance the standard of life and welfare of individuals who are struggling with this MDD.
Knowledge of Dental Caries Status in Diabetes Mellitus Patients
Authors:   Department of Dental Health, Health Polytechnic of Jakarta I, Indonesia, Fadjeri Indrayati , Purnama Tedi ,   Department of Dental Health, Health Polytechnic of Jakarta I, Indonesia, Lestari Syifa Yulia ,   Department of Dental Health, Health Polytechnic of Jakarta I, Indonesia, Ngatemi Ngatemi ,   Department of Dental Health, Health Polytechnic of Jakarta I, Indonesia
Published: December 2024

Background: Diabetes mellitus is a chronic disease that has a significant impact on dental and oral health, including a high risk of dental caries. The level of individual knowledge about oral health care is considered to have an important role in preventing caries in patients with diabetes mellitus. This study aims to analyze the relationship between the level of knowledge and the status of dental caries in patients with diabetes mellitus.

Methods: This study used a cross-sectional design involving 61 diabetes mellitus selected by purposive sampling from the Dentica Pondok Labu clinic, South Jakarta. Knowledge data were obtained through a validated questionnaire, while caries status was measured using the DMFT (Decayed, Missing, Filled Teeth) index. Data analysis was performed using the chi-square test.

Results: The average knowledge score of respondents was 75.14 ± 12.16 (scale 0-100). The average DMFT index was 7.38 ± 3.707. Chi-square analysis showed a significant relationship between the level of knowledge and the DMFT index (p < 0.000).

Conclusion: This study shows that the level of knowledge has a significant relationship with the status of dental caries in patients with diabetes mellitus. More intensive educational efforts about dental and oral health are needed to reduce the risk of caries in patients with diabetes mellitus.
Cultivo de hortalizas de ciclos cortos en huertos para el consumo y comercialización de alumnos de tercero de bachillerato
Authors: Bazán Alarcón Reina , Cottallat Villao Edgar Leonidas , García Hevia Segress
Published: December 2024

La agricultura urbana surge como una solución viable al proporcionar acceso a alimentos frescos y nutritivos, especialmente para poblaciones vulnerables. En este contexto, el presente estudio tiene como propósito desarrollar una propuesta metodológica que permita implementar huertos escolares en la Unidad Educativa Misael Olaya especialmente en bachillerato, como parte de su formación técnica, el currículo ecuatoriano se estructura sistemáticamente en niveles y subniveles que contribuyen la formación del bachillerato, la seguridad alimentaria enfrenta desafíos globales, exacerbados por la pobreza y la desigualdad, con un enfoque en el cultivo de hortalizas de ciclo corto, su consumo y su posible comercialización. La metodología utilizada se basa en un enfoque mixto que combina análisis cuantitativo y cualitativo. Se aplicaron cuestionarios y entrevistas a estudiantes y docentes para recopilar información, complementada con un análisis estadístico. Los resultados muestran que, si bien los estudiantes poseen conocimientos básicos sobre el cultivo de hortalizas, existe una necesidad de fortalecer las actividades prácticas y el aprendizaje experimental. El huerto escolar se presenta como una herramienta clave para mejorar la educación agrícola, fomentar hábitos alimenticios saludables y promover el emprendimiento juvenil.
El rol del docente en la pedagogía culturalmente receptiva
Authors: Sornoza-Delgado Yolanda Mariana
Published: December 2024

La pedagogía culturalmente receptiva busca integrar la diversidad cultural en los procesos educativos, promoviendo una educación inclusiva y equitativa. Este artículo tiene como objetivo analizar, mediante una revisión bibliográfica, las competencias necesarias, los desafíos y las estrategias para implementar esta pedagogía. Se adoptó un enfoque exploratorio basado en el análisis de literatura académica indexada en bases de datos como Scopus y Web of Science, considerando investigaciones relevantes de los últimos veinte años. Los resultados destacan la necesidad de desarrollar competencias interculturales en los docentes, como la sensibilidad cultural y la capacidad para diseñar estrategias pedagógicas adaptadas a la diversidad estudiantil. Sin embargo, se identificaron barreras como la insuficiente formación docente y la falta de recursos educativos inclusivos, lo que perpetúa desigualdades en el sistema educativo. En la discusión, se subraya la importancia de políticas educativas, capacitación continua y recursos adaptados para superar estas barreras. En conclusión, la pedagogía culturalmente receptiva es una herramienta esencial para mejorar la calidad educativa, siempre que se aborden las limitaciones estructurales y culturales que condicionan su éxito, fomentando así ambientes inclusivos que valoren y respeten la diversidad cultural.
Estrategias y técnicas innovadoras de lectoescritura y cálculo para niños regulares, con necesidades educativas especiales y trastornos de aprendizaje
Authors: Nuñez-Espin Ruth Alicia
Published: December 2024

El presente estudio aborda estrategias pedagógicas innovadoras para la enseñanza de la lectoescritura y el cálculo en niños regulares, con necesidades educativas especiales y trastornos de aprendizaje, destacando la importancia de enfoques inclusivos en la educación. Mediante un enfoque cualitativo y exploratorio, se realizó un análisis exhaustivo de literatura científica, priorizando métodos multisensoriales, herramientas tecnológicas y técnicas lúdicas. Los resultados identificaron que los enfoques multisensoriales facilitan la comprensión lectora y textual, mientras que las tecnologías adaptativas personalizan el aprendizaje y fortalecen habilidades matemáticas. Asimismo, las actividades lúdicas y narrativas visuales incrementan la motivación y el compromiso de los estudiantes. En el ámbito inclusivo, la adaptación curricular, la formación continua del profesorado y la promoción de ambientes educativos integradores destacan como factores esenciales. Estos hallazgos refuerzan la importancia de un modelo educativo que valore la diversidad y promueva un aprendizaje equitativo. No obstante, se identificaron desafíos en la accesibilidad a recursos tecnológicos y en la capacitación docente, lo que exige un enfoque integral y colaborativo. Este estudio contribuye al diseño de prácticas pedagógicas basadas en evidencia, promoviendo un sistema educativo inclusivo y adaptado a la diversidad estudiantil.
El papel del juego en el desarrollo del lenguaje: estrategias innovadoras para la educación primaria
Authors: Morán Larreátegui Tannya Leonor , Abad Heredia Cecilia Maribel , Domínguez Fernández Janeth Alexandra , Alvear Sagal Héctor Rafael , Tituaña Sánchez Luis Gerardo , Ruiz Gaona Paulina Gabriela
Published: December 2024

El presente artículo explora el rol del juego en el desarrollo del lenguaje en la educación primaria, proponiendo estrategias innovadoras para integrar actividades lúdicas en el aula. En el contexto de un sistema educativo que suele priorizar métodos convencionales, esta investigación destaca el potencial del juego para fomentar habilidades lingüísticas y cognitivas en niños de edad temprana. Mediante una revisión sistemática de estudios recientes, se analizaron las modalidades de juego guiado, libre, simbólico y de roles, identificando sus efectos específicos en aspectos como el enriquecimiento de vocabulario, la construcción narrativa y la expresión oral. Los resultados sugieren que el juego guiado facilita la adquisición de vocabulario contextualizado, mientras que el juego libre promueve la creatividad y flexibilidad lingüística. Asimismo, el juego simbólico y de roles contribuyen a la complejidad gramatical y al desarrollo de habilidades pragmáticas, esenciales para una comunicación efectiva. Las conclusiones resaltan la importancia de incluir el juego como herramienta pedagógica en los currículos escolares, subrayando que esta integración favorece no solo el aprendizaje lingüístico, sino también el desarrollo emocional y social de los estudiantes.