bluuebunny/crossref_metadata_2025 huggingface dataset:
The Efficacy of Oxysophocarpine in Treating Cerebral Ischemia: Integration of Network Pharmacology and Experimental Validation
Authors: Wang Zhi , Qiao Haiqi , Yu Yang , Liu Siyun , Zhao Fang , Zhou Ru
Published: January 2025

Objective:

The underlying mechanisms of Oxysophocarpine (OSC) in Cerebral Ischemia
(CI) treatment were investigated through network pharmacology, molecular docking, and in vitro
experiments.

background:

CI is a neurological disorder precipitated by a blood clot, which obstructs cerebral blood flow, resulting in inadequate oxygen and nutrient supply to the brain tissue. Prolonged cerebral ischemia can lead to persistent or progressive neurological and cognitive deficits. The primary treatment involves promptly restoring blood flow to the ischemic brain tissue post-ischemia. Despite this, effective therapeutic drugs remain lacking.

Methods:

The potential targets of OSC were predicted using the PubChem, SwissTargetPrediction,
and PharmMapper databases. Relevant CI targets were identified through the GeneCards and Online
Mendelian Inheritance in Man (OMIM) databases, and common targets between OSC and cerebral
ischemia were determined using Venny2.1.0. Drug-disease Protein-Protein Interaction (PPI) networks
were analyzed using the String database. Gene Ontology (GO) and Kyoto Encyclopedia of
Genes and Genomes (KEGG) enrichment analyses of key targets were conducted using the DAVID
database. Molecular docking verification was performed using Autodock Vina. The results of the
network pharmacological analysis were validated through in vitro experiments.

Results:

Mapping the drug and disease targets yielded 126 common targets. GO and KEGG enrichment
analysis revealed that OSC's therapeutic mechanism in CI involves multiple pathways, including
those related to cancer, MAPK signaling, and PI3K-Akt signaling. Molecular docking results
demonstrated strong binding activity of OSC to core protein targets. In vitro experiments indicated
that OSC enhances the survival rate of four hours of sugar deprivation and 12 hours of reoxygenation
(OGD4h/R12h) in bEnd.3 cells and reduces the protein expression of p-PI3K and p-Akt.

Conclusion:

The "multi-target and multi-mechanism" actions of OSC in CI treatment were elucidated
through network pharmacology and molecular docking, providing a scientific basis for further
investigation.
Risk factors for Mortality in Patients with COVID-19 in CuernavacaMorelos
Authors: Hernández Jorge Martín Rodríguez , Hernández Cidronio Albavera , Troya Arsenio Hidalgo , Garzón Flor Stella Piñeros , Rojas Sarahi Rodríguez
Published: January 2025

Background:

The world changed in December 2019 due to respiratory tract infection
cases, initially of unknown etiology, later known as COVID-19.

Objective:

This study aimed to determine the factors and comorbidities associated with mortality
from COVID-19 in Mexico.

Methods:

It was a cross-sectional and observational prospective study of patients treated at an
IMSS (Mexican Institute of Social Security) Hospital in Morelos with a confirmed diagnosis of
COVID-19. Logistic regression models and survival analyses were developed to identify factors
associated with mortality risk.

Results:

3,965 patients were analyzed, with most deaths occurring in men. The mortality risks
were higher in men who were older than 50 years. The most significant associations were: age older than 80 years (HR:3.17), endotracheal intubation (HR:1.54), dyspnea (HR: 13.55), and polypnea (HR:1.54).

result:

3,965 patients with COVID-19 were analyzed. Most of the deceased were men. The instantaneous risk of mortality from COVID-19 was higher in men older than 50 years. The variables with the most significant association were age older than 80 years (HR:3.17), endotracheal intubation (HR:1.54), dyspnea (HR: 13.55), and polypnea (HR:1.54).

Conclusion:

The risk of death in this population was high, considering the absence of primary protective measures at the beginning of the pandemic and the lack of consistency in using personal
protection elements.
DHA Supplement in Pregnant Women Life's Flow: Measure Before You
Bestow
Authors: Sharma Ritika , Thakur Shubham
Published: January 2025

Docosahexaenoic Acid (DHA) supplementation is regarded as safe and beneficial to
maternal health before, during, and after pregnancy. DHA is indeed an important fatty acid, and
its requirement is elevated during pregnancy due to fetal brain and eye development requirements.
Despite its established importance, there is no established Recommended Dietary Allowance (RDA)
for DHA, unlike other essential nutrients. The other gap in the estimated average minimum
required intake is due to individual differences in the needs of DHA among individuals. This depends
on an individual’s diet, metabolism, and genetic effects. Although there are guides on the
minimum daily intake, measurement using blood tests still remains the best way to determine an
individual's needs. Therefore, patients should first consider monitoring their DHA concentration
and then adjust supplementation according to personal requirements. Among the existing choices
of DHA supplementations, traditional soft-gel capsules present some drawbacks viz lower stability,
lower bioavailability, and organoleptic problems such as a fishy aftertaste. The emulsion-based
DHA formulations, on the other hand, offer a better alternative with higher stability, better bioavailability,
and a favorable taste profile. Therefore, the editorial highlights the need for tailored approaches
such as estimating the baseline reference range in individuals’ blood and then supplementing
the individual with DHA using novel delivery systems, such as emulsions. These tailored
approaches will further enhance maternal and fetal health.
Exploring the Involvement of New Members of the Interleukin Family in Cardiovascular Disease
Authors: Al Noman Abdullah , Flora Sanzida Alam , Datta Monty , afrose Fahmida , Binte Hasan Nushaiba , Akhter Tahamina , Anuva Nayeema Jameel , Pathak Rashmi , Sharma Himanshu
Published: January 2025

Cardiovascular diseases remain a significant reason for illness and death globally.
Although certain interleukins have been extensively researched about cardiovascular disease
(CVD), new findings have identified unique members of the interleukin family that could potentially
play a role in cardiovascular well-being and ailments. This review discusses the current
understanding of the role of these recently identified interleukins, such as IL-27, IL-31, IL-32,
IL-33, and the IL-28 group (IL-28A, IL-28B, IL-29), in the development of cardiovascular diseases.
Every interleukin has various impacts achieved through particular receptors and signaling
pathways that affect inflammatory processes, differentiation of immune cells, and the functioning
of blood vessels. IL-27 controls the development of inflammatory Th17 cells and might decrease
inflammation in atherosclerosis. IL-31 plays a role in the interaction between the immune
system and nerves, as well as in itching. IL-32 enhances the generation of inflammatory proteins
and has been linked to coronary artery disease. IL-33 has beneficial effects on the cardiovascular
system, whereas its imitation receptor sST2 could potentially be used as a biomarker. Additional
studies are needed to investigate the antiviral and immune-system regulating effects of the IL-28
group in cardiovascular diseases. In general, explaining the ways in which new interleukins contribute
to the progression of cardiovascular diseases can help discover fresh targets for therapy
and new approaches toward enhancing the prevention and treatment of heart disorders. Additional
research on the way these cytokines engage with established disease pathways is necessary.
Deep Learning-assisted Diagnosis of Extrahepatic Common Bile Duct Obstruction Using MRCP Imaging and Clinical Parameters
Authors: Thoi Do Kieu Trang , Lim Jung Hyun , Park Jin-Seok , Park Suhyun
Published: January 2025

Background:

Extrahepatic Common Bile Duct Obstruction (EHBDO) is a serious condition that requires accurate diagnosis for effective treatment. Magnetic
Resonance Cholangiopancreatography (MRCP) is a widely used noninvasive imaging technique for visualizing bile ducts, but its interpretation can
be complex.

Objective:

This study aimed to develop a deep learning-based classification model that integrates MRCP images and clinical parameters to assist radiologists
in diagnosing EHBDO more accurately.

Methods:

A total of 465 patients with clinical data were included, of whom 143 also had MRCP images. Missing clinical values were addressed through data
imputation. Object detection techniques were used to isolate the common bile duct region in the MRCP images. A multimodal deep learning fusion
model was developed by combining the extracted imaging features with selected clinical parameters. To account for the varying significance of
different features, a weighted loss function was applied. The performance of the fusion model was compared to that of single-modality approaches
(using only MRCP images or clinical data), specifically the accuracy, sensitivity, specificity, and Area Under The Curve (AUC).

Results:

The performance of the proposed deep learning fusion model was superior to that of models using only MRCP images or clinical parameters. The
fusion model achieved an accuracy of 89.8%, AUC of 90.4%, sensitivity of 81.8%, and specificity of 95.7% in diagnosing EHBDO. By integrating
MRCP imaging data and clinical parameters, the proposed deep learning model significantly enhanced the accuracy of EHBDO diagnosis.

Conclusion:

This proposed multimodal approach outperformed traditional single-modality methods, presenting a valuable tool for improving the diagnostic
accuracy of bile duct obstruction.
Comparative Study on Sedative and Hypnotic Effects of Crude and Parched Semen Ziziphi Spinosae: Integration of Network Pharmacology and In Vivo Pharmacological Evaluation
Authors: Xia Jing , Cai Ming , Xu Bo , Xie Guang-Jing , Wang Ping
Published: January 2025

Objective:

This study aimed to investigate the medicinal properties of SZS before and
after processing and provide novel insights into its potential for treating insomnia.

Methods:

This study employed the network pharmacology platform to gather information on the
chemical composition of SZS, human targets, genes, molecular networks, and pathways associated
with insomnia treatment using SZS. Liquid chromatography-tandem mass spectrometry (LC-MS/
MS) was utilized to analyze the chemical profiles of crude SZS, parched SZS, and their combined
decoction. The effects of different SZS products on p-chlorophenylalanine-induced insomnia
mice were evaluated through pentobarbital-induced sleep tests, behavioral analyses, examination
of brain tissue-related mRNA levels, and measurement of plasma neurotransmitters, aiming
to explore the sedative and hypnotic effects of various SZS products.

Results:

SZS was found to contain a total of 47 genes, including 22 target genes associated with
insomnia. These genes may contribute to the sedative and hypnotic effects through 9 related pathways
and 69 biological processes. The active components of SZS remained consistent before and
after processing. Jujuboside B was found in higher concentrations in crude SZS, while jujuboside
A was more abundant in parched SZS. Additionally, SZS exhibited reduced locomotor activity in
mice, enhanced the hypnotic effect of pentobarbital sodium, and decreased the levels of acetylcholinesterase,
α-1B adrenergic receptor, and solute carrier family 6 member 4 mRNA in the cortex
and hippocampus of mice. The levels of acetylcholine, choline acetyltransferase, 5-hydroxyindoleacetic
acid, and glutamate in plasma increased, with the hypnotic effect being proportional to
the dosage of the drug.

Conclusion:

SZS demonstrates sedative and hypnotic effects, potentially mediated by its influence
on neurotransmitter levels and related receptors within the central nervous system. There was
a slight variation in regulatory capabilities before and after SZS processing, with the combined decoction
of crude and parched SZS exhibiting a more pronounced effect, particularly at higher
dosages.

conclusion:

SZS demonstrates sedative and hypnotic effects, potentially mediated by its influence on neurotransmitter levels and related receptors within the central nervous system. There was a slight variation in regulatory capabilities before and after SZS processing, with the combined decoction of crude and parched SZS exhibiting a more pronounced effect, particularly at higher dosages.
Microbial Communities in Coastal Salt Marshes Along the Southeast Coast of China and Their Effects on Carbon Storage
Authors: Lv Chunguang , Li Yan , Wang Chenyi , Zhang Huining , Ren Min , Zhang Chiqian
Published: January 2025

Background:

Wetlands are vital carbon sinks, with coastal salt marshes being particularly
effective in carbon sequestration. Understanding how different vegetation types influence soil carbon
storage and microbial composition can enhance our knowledge of these ecosystems’ roles in global
carbon cycling.

Methods:

This study investigates soil physicochemical properties, soil carbon storage, and microbial
community composition and diversity at three depths (10, 30, and 60 cm) in five salt marsh plots
from five coastal salt marshes: Bare flat (a non-vegetated marsh) and plots dominated by Imperata
cylindrica, Solidago canadensis, Suaeda spp., and Phragmites australis. Carbon storage was evaluated
by measuring soil organic carbon (SOC) content. At the same time, high-throughput sequencing
was employed to analyze microbial communities, aiming to elucidate their relationships with soil
carbon storage and wetland vegetation.

Results:

The average SOC contents in the five plots were in the order of S. canadensis (13.33 g·kg–
1) > Bare flat (11.45 g·kg–1) > Suaeda spp. (8.10 g·kg–1) > I. cylindrica (6.15 g·kg–1) > P. australis
(5.80 g·kg–1). S. canadensis and Bare flat marshes had the highest carbon content, which is mainly
attributed to the presence of the most abundant carbon-fixation microbes, Fulvivirgaceae (family)
and Acidobacteria RB41 (genus), in the soil of these two plots. Both organic and dissolved organic
carbon contents at 10 cm were higher than those at the other two depths for all five marshes.

Conclusion:

The Bare flat exhibited strong carbon sequestration capability, second only to the invasive
S. canadensis plot among the five plots surveyed. It also showed the highest microbial abundance
and the greatest number of carbon-sequestration-related functional genes. The S. canadensis
plot exhibited the lowest microbial community diversity and abundance despite having the highest
carbon storage capacity. As an invasive species, S. canadensis should be removed to mitigate its
ecological impact.
Chlorogenic Acid Ameliorates CCl4-induced Liver Fibrosis by Modulating the
PI3K/AKT/mTOR Autophagy Pathway
Authors: Negm Amr , El-neanaey Amira A. , Khadr Abada El Sayed , Kamel Maher Abd El Naby , Abdo Ismail Abd El-Hamid , El Sayed Ibrahim El Tantawy , Darwish Wael Sobhy , Abd Eldaim Mabrouk Attia , Okaz Raghda Sobhy , Bahr Mohamed Hamdy , Almuraikhi Nihal , Beshara Nermine , Shawky Tamer M. , Mersal Ezat A.
Published: January 2025

Background:

Liver fibrosis represents a serious risk to global health by impairing quality of life and
elevating the chances of hepatocellular carcinoma, while the intricate role of autophagy can either alleviate or
worsen fibrosis depending on its functioning.

Objective:

Herein, we aimed to investigate the therapeutic effect of chlorogenic acid in CCl4-induced hepatic
fibrosis and explore the autophagy pathway as the possible molecular target of chlorogenic acid.

Methods:

Rats were injected with carbon tetrachloride (1ml/kg) to induce liver fibrosis for 10 weeks. In the current study, the liver fibrosis rats were treated daily with chlorogenic acid (20, 40, and 60 mg/kg) for 30 days.
Liver function tests, renal function tests, lipid peroxidation, antioxidant enzyme, anti-inflammatory NF-κB level,
and autophagy pathway parameters (PI3K, AKT, mTOR, LC3, and Beclin-1) were assessed.

Results:

CCl4 elevated serum AST and ALT activity, and hepatic malondialdehyde, PI3K, AKT, and mTOR
expressions. It decreased LC3, Beclin-1 expression, and hepatic glutathione level. The results indicated that
chlorogenic acid treatment ameliorated the hepatic functions. It declined serum AST and ALT activities, improved hepatic GSH concentration, decreased lipid peroxidation, and downregulated PI3K, AKT, and mTOR
protein expressions in hepatic tissue. Moreover, chlorogenic acid increased the hepatic expression of LC3 and
Beclin-1. It also significantly decreased NF-kB expression.

Conclusion:

Chlorogenic acid showed promise in reducing liver damage in rats caused by CCl4 by influencing
the autophagy process and adjusting levels of antioxidant and inflammatory markers.
Effects of Citrus-derived Diosmetin on Melanoma: Induction of Apoptosis and
Autophagy Mediated by PI3K/Akt/mTOR Pathway Inhibition
Authors: Li jie , Xu Mingyuan , Wu Nanhui , Wu Fei , Chen Jiashe , Xu Xiaoxiang , Tan Fei , Liu Yeqiang
Published: January 2025

Background:

Diosmetin (DIOS) is a naturally abundant flavonoid and possesses various biological
activities that hold promise as an anti-cancer agent. However, the anti-cancer activities and underlying mechanism of DIOS on cutaneous melanoma remain unclear.

Objective:

This study seeks to explore the anti-tumor effect and mechanism of DIOS in cutaneous melanoma.

Methods:

Here, a variety of in vitro and in vivo experiments, combined with RNA sequencing (RNA-seq), were
employed to ascertain the potential anti-cutaneous melanoma capacity and mechanism of DIOS.

Results:

The results demonstrated that DIOS considerably impeded cell proliferation and triggered cell apoptosis
in a dose- and time-dependent manner. Concurrently, DIOS markedly elevated the expression of pro-apoptotic
proteins (Cleaved caspase-3, Bax, Cleaved PARP, and Cleaved caspase-9) and downregulated the expression of
Bcl-2. Additionally, DIOS markedly upregulated the protein expressions of LC3B-II and Atg5, while downregulating p62 protein expression. Notably, pre-treatment with an autophagy inhibitor significantly inhibited DIOSinduced cell apoptosis and autophagy. Mechanistically, DIOS was identified to repress the PI3K/Akt/mTOR
signaling pathway by western blot analyses and RNA-seq. Finally, in vivo experiments using a syngeneic mouse
model confirmed the anti-tumor effect of DIOS, which exhibited high levels of apoptosis and autophagy.

Conclusion:

These findings propose that DIOS acts as a potential melanoma therapy that exerts its anti-tumor
effects by triggering apoptosis and autophagy via inhibition of the PI3K/Akt/mTOR pathway
The Trend of Prehospital Emergency Medical Care Services after the COVID-19 Pandemic: A Time Series Analysis
Authors: Karimifard Mousa , Hosseini Mahmood , Mahmudimanesh Marzieh , Jahanghiri Fereshteh , Mahmoodi Reza , Talebi Hadi , Soodejani Moslem Taheri
Published: January 2025

Introduction

The COVID-19 epidemic in 2019 directly or indirectly had an impact on the healthcare system of hospitals. Iran was among the countries whose hospitals and especially the emergency system were affected by the outbreak of Coronavirus. The main objective of this study is to compare the number of emergency services, including heart and respiratory diseases, accidents, drowning, and CO poisoning, after the coronavirus pandemic in Chaharmahal and Bakhtiari provinces.

Methods

In this study, after obtaining the necessary permissions, an attempt was made to analyze the data on the most common Emergency Medical Services (EMS) extracted monthly by the city from the ASAYAR system during 2020-2023 using time series and Auto-regressive Integrated Moving Average (ARIMA) model.

Results

The number of emergency services related to accidents had an upward trend and was based on seasonal changes. Examination of seasonal effects shows that most emergency services occurred in the months of June through September; the number of emergency services related to heart disease was relatively constant. In addition, the number of emergency services related to respiratory diseases was constant on average despite many fluctuations in the observations. During the COVID-19 pandemic, the number of interventions and emergency calls increased.

Conclusion

Therefore, emergency services should increase their response capacity in these cases by modifying their programs and approaches, increasing response capacity and the number of staff, and providing appropriate training.
Os livros de música nos inventários do mosteiro de São Miguel de Refojos de Basto
Authors: Sánchez Rosa María Sánchez
Published: January 2025

This article stems from the project “Letters in the Cloister: Monastic Libraries in Northern Portugal from the Middle Ages to the 19th Century.” It focuses particularly on the analysis of music books documented in the inventories that were the subject of study, belonging to the Monastery of Saint Michael of Refojos de Basto
Pengaruh Promosi, Citra Merek, Dan Pengalaman Pelanggan Terhadap Niat Pembelian Kembali
Authors: Muharram Rizky Akbar , Puspaningrum Astrid
Published: January 2025

Online travel agents are online-based travel agents that provide tourism products and services such as hotel reservation and public transportation ticket purchase. In Indonesia nowadays they are growing rapidly along with multiple types and competitors. PT Traveloka Indonesia is one of the key players in this business. The objective of this research is to analyze and explain the effects of promotion, Brand Image, and Customer Experience on airplane ticket repurchase intention through Traveloka in Malang City. The population of this explanatory research is people of Malang City who have the experience of purchasing airplane ticket through Traveloka. Using non-probability sampling method and purposive sampling technique, 140 people with the minimum age of seventeen years who have purchases airplane ticket through Traveloka at least once were selected as the sample. The results of the analysis using multiple linear regression indicate that promotion, Brand Image, and Customer Experience have positive and significant effects on repurchase intention.
 
Abstrak
Online Travel Agent adalah agen perjalanan berbasis online yang menyediakan produk dan layanan pariwisata, seperti reservasi hotel dan pembelian tiket transportasi publik. Saat ini, Online Travel Agent sedang berkembang secara pesat dengan pesaing yang banyak dan tipe yang beragam di Indonesia. PT. Traveloka Indonesia merupakan salah satu pemain kunci dalam bisnis ini. Penelitian ini bertujuan untuk menganalisis dan menjelaskan pengaruh Promotion, Brand Image, Customer Experience terhadap Repurchase Intention tiket pesawat Traveloka di Kota Malang. Jenis penelitian ini adalah explanatory research. Teknik pengambilan sampel yang digunakan dalam penelitian ini adalah non-probability sampling dengan menggunakan metode purposive sampling. Populasi dalam penelitian ini adalah masyarakat Kota Malang yang pernah membeli tiket pesawat melalui Traveloka dan diperoleh sampel sebanyak 140 responden dengan kriteria responden minimal berusia 17 tahun dan pernah membeli tiket pesawat melalui Traveloka minimal sebanyak satu kali. Penelitian ini menggunakan analisis linier berganda dan hasil penelitian ini menunjukkan bahwa Promotion, Brand Image, dan Customer Experience memiliki pengaruh positif dan signfikan terhadap Repurchase Intention.
Penguatan Sikap Nasionalisme Peserta Didik SMP Muhammadiyah 1 Wonosobo
Authors: Wulandari Renny Aulia Putri , Suyato Suyato
Published: January 2025

Penelitian ini bertujuan untuk mendeskripsikan penguatan sikap nasionalisme peserta didik SMP Muhammadiyah 1 Wonosobo. Penelitian ini merupakan penelitian deskriptif kualitatif. Subjek penelitian ini adalah guru dan siswa kelas IX. Teknik pengumpulan data menggunakan observasi, wawancara, dan studi dokumentasi. Analisis data menggunakan langkah-langkah reduksi data, penyajian data, dan penarikan kesimpulan atau verifikasi. Hasil penelitian menunjukkan bahwa cara guru untuk mengajarkan sikap nasionalisme melalui mata pelajaran PKn antara lain dengan pembiasaan, keteladanan, pemberian contoh yang kontekstual, pembelajaran melalui cerita dan media, seperti gambar pahlawan dan lagu nasional. Hal yang paling efektif dilakukan oleh guru diantara cara tersebut adalah pembiasaan dan keteladanan karena dapat dilakukan guru setiap hari. Perwujudan sikap nasionalisme siswa antara lain perilaku rela berkorban, cinta tanah air, bangga sebagai bangsa Indonesia, persatuan dan kesatuan, patuh terhadap peraturan, disiplin, berani, jujur, serta bekerja keras. Perilaku siswa yang paling menonjol diantara aspek tersebut adalah kerja keras karena guru melakukan pembiasaan kepada siswa untuk aktif ketika pembelajaran. Penyebab terhambatnya penanaman sikap nasionalisme antara lain keterbatasan media pembelajaran, waktu, serta kesenjangan antara lingkungan keluarga dan masyarakat.
Upaya Komite Kesejahteraaan dan Perlindungan Anak (KKPA) Tunas Nugraha dalam Mewujudkan Pemenuhan Hak-Hak Anak
Authors: Utami Bela , Kusdarini Eny
Published: January 2025

Artikel ini ditulis berdasarkan hasil penelitian yang berjudul "Peranan Komite Kesejahteraan Dan Perlindungan Anak (KKPA) dalam Perwujudan Perlindungan Anak Kalurahan Mulyodadi Kapanewon Bambanglipuro Kabupaten Bantul" dengan tujuan untuk mendiskripsikan pemenuhan hak-hak anak di Kalurahan Mulyodadi Kapanewon Bambanglipuro Kabupaten Bantul.Penelitian ini adalah penelitian deskriptif. Penetuan subjek penelitian menggunakan purposive. Teknik pengumpulan data menggunakan metode wawancara dan dokumentasi. Teknik analisis data melalui reduksi data, unitisasi dan kategorisasi data, penyajian data, penarikan kesimpulan dan verifikasi.Dalam pratiknya pemerintah dalam memberikan hak-hak anak dilingkup Kalurahan sudah ada. Hasil penelitian menujukan bahwa upaya Komite Kesejahteraan Dan Perlindungan Anak (KKPA) Tunas Nugraha dalam mewujudkan pemenuhan hak-hak anak melalui peranannya dengan sososialisasi dan berkerjasama dengan lembaga-lembaga berwenang terkait perlindungan yakni Polres dan Pusat Pelayanan Terpadu Pemberdayaan Perempuan dan Anak (P2TP2A).
Taraf Keterlibatan Aktif Pemilih Menggunakan Hak Pilih Dalam Pilkada Serentak 2020
Authors: Aulia Agnes , Suharno Suharno
Published: January 2025

ABSTRAKArtikel ini bertujuan untuk menganalisis bagaimana tingkat partisipasi pemilih dalam Pilkada Serentak 2020 Kecamatan Seyegan. Kemudian juga untuk menganalisis apa saja kendala yang dihadapi untuk berpartisipasi dalam Pilkada Serentak 2020 Kecamatan Seyegan dan menganalisis bagaimana cara mengatasi kendala yang dihadapi untuk berpartisipasi dalam Pilkada Serentak 2020 Kecamatan Seyegan.Tingkat partisipasi pemilih Kecamatan Seyegan menggunakan hak pilihnya dalam Pilkada Serentak 2020 di era pandemi Covid-19 mengalami peningkatan cukup tinggi. Hal ini berarti terdapat peningkatan trend dalam penyelenggaraan Pilkada Serentak 2020 dan angka partisipasi Kecamatan Seyegan sudah mencapai target yang ditetapkan oleh Provinsi Daerah Istimewa Yogyakarta. Terdapat enam kendala dalam penyelenggaraan Pilkada Serentak 2020, yaitu: perlengkapan fasilitas yang meningkat, pembengkakan anggaran yang dikeluarkan, Citamasjajar yang belum maksimal, pembatasan kerumunan, shift pelaksanaan yang lama, dan ketakutan Covid-19 dalam kluster TPS. Cara mengatasi kendala yang dihadapi untuk berpartisipasi dalam Pilkada Serentak 2020 ada tiga, yaitu: peningkatan kinerja sosialisasi dan komunikasi, peninjauan Kembali protokol kesehatan agar memberikan sanksi yang jelas, dan penerapan metode digitalisasi untuk pemilihan umum yang akan datang.Penelitian ini merupakan penelitian kualitatif deskriptif. Teknik pengumpulan data dengan wawancara dan dokumentasi. Pemeriksaan keabsahan data dengan cara cross check. Teknik analisis data dilakukan melalui reduksi data, penyajian data, dan penarikan kesimpulan.
Pelayanan administrasi kependudukan terpadu melalui aplikasi SIPAKDE di Kapanewon Depok
Authors: Ridho Muhammad Taufiq , Suharno Suharno
Published: January 2025

Artikel ini didasarkan pada penelitian yang bertujuan untuk mendeskripsikan kebijakan aplikasi SIPAKDE dalam mengupayakan peningkatan pelayanan publik, menganalisis faktor yang menjadi penghambat pemerintah Kapanewon Depok dalam menjalankan Kebijakan Aplikasi SIPAKDE, menganalisi upaya yang dilakukan pemerintah Kapanewon Depok dalam mengatasi hambatan menjalankan kebijakan Aplikasi SIPAKDE. Pada masa pandemi covid-19, Instansi pemerintah harus mampu memberikan solusi terbaik agar memberikan kualitas pelayanan yang efektif dan efisien bagi masyarakat. Terkhusunya Kapanewon Depok yang berinovasi dalam membuat aplikasi sebagai bentuk efektifitas pelayanan publik. Keinginan masyarakat agar dapat melakukan pelayanan adminitrasi secara mudah dan cepat, ditambah pandemi covid-19 pelayanan administrasi kependudukan harus tetap diberikan walaupun ada Batasan mobiltas. untuk itu dikeluarkan aplikasi SIPAKDE agar masyarakat mampu mengurus administrasi kependudukan dirumahdan juga berkulaitas, sehingga mengurangi kegiatan diluar rumah dan mampu menekan penularan virus covid-19. Penelitian ini merupakan penelitian deskripstif dengan pendekatan kualitatif. Teknik pengumpulan data menggunakan teknik observasi, wawancara dan dokumentasi. Teknik pengecekan keabsahan data yang digunakan teknik Triangulasi. Teknik analisis yang digunakan adalah teknik analisis data induktif dengan tahapan: reduksi data, kategorisasi data, penyajian data, dan penarikan simpulan/verifikasi.
Pendidikan Pancasila dan Kewarganegaraan untuk Menanamkan Karakter Demokratis Di SMA Negeri 1 Semanu
Authors: Berliana Yassinta Isna , Hayati Iffah Nur
Published: January 2025

ABSTRAKPenelitian ini bertujuan untuk (1) mendeskripsikan penanaman karakter demokratis melalui pembelajaran Pendidikan dan Pancasila dan Kewarganegaraan SMA Negeri 1 Semanu; (2) mengetahui hambatan dalam penanaman karakter demokratis melalui pembelajaran Pendidikan Pancasila dan Kewarganegaraan SMA Negeri 1 Semanu. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif.. Subjek penelitian ini yaitu guru PPKn yang ditentukan dengan teknik purposif. Teknik pengumpulan data menggunakan wawancara, observasi, dan dokumentasi. Untuk kepentingan validasi data digunakan teknik triangulasi. Analisis data dalam penelitian penelitian kualitatif ini menggunakan reduksi data, kategorisasi, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan penanaman karakter demokratis dilakukan melalui penyampaian materi, metode pembelajaran, dan keteladanan. Penyampaian meteri dilakukan dengan memberikan pemahaman secara kognitif mengenai karakter demokratis. Metode pembelajaran yang digunakan yaitu ceramah, diskusi kelompok, dan Snowball Throwing. Keteladanan dilaksanakan dengan guru sebagai model serta panutan sabar, sikap dan tindakan sesuai dengan karakter demokratis. Hambatan dalam penanaman karkater demokratis yaitu kurangnya rasa percaya diri peserta didik, kurangnya perhatian peserta didik terhadap kegiatan belajar mengajad, dan kurangnya pengembangan strategi pembelajaran yang digunakan oleh guru dalam menanamkan karakter demokratis melalui Pendidikan Pancasila dan Kewarganegaraan.
Penggunaan Game Mobile Legends dan pengaruhnya terhadap perilaku hate speech siswa SMA Negeri 1 Karangmojo Kabupaten Gunungkidul
Authors: Suryandari Lutvi , Suyato Suyato
Published: January 2025

ABSTRAKPenelitian ini bertujuan untuk mengetahui pengaruh penggunaan Game Mobile Legends terhadap perilaku hate speech siswa SMA N 1 Karangmojo Kabupaten Gunungkidul. Penelitian ini menggunakan pendekatan kuantitatif dan metode penelitian yang digunakan adalah penelitian ex-post facto. Sampel dalam menggunakan teknik sampling berupa Sampling Purposive. Teknik pengumpulan data menggunakan kuesioner. Uji validitas penelitian ini menggunakan rumus korelasi product moment dan uji reliabilitas penelitian ini menggunakan rumus Cronbach Alpha. Adapun teknik analisis data yang digunakan dalam penelitian ini adalah analisis deskriptif dan analisis regresi linier sederhana dengan menggunakan program SPSS 22. Hasil penelitian ini membuktikan bahwa penggunaan Game Mobile Legends memiliki pengaruh terhadap perilaku hate speech siswa (signifikansi0,05). Adapun koefisien determinasi sebesar 0,239 yang berarti kontribusi pengaruh yang diberikan penggunaan Game Mobile Legends terhadap perilaku hate speech sebesar 23,9%. Sehingga dapat disimpulkan bahwa penggunaan Game Mobile Legends berpengaruh terhadap perilaku hate speech siswa SMA Negeri 1 Karangmojo Kabupaten Gunungkidul.
ajian peranan bawaslu Kabupaten Purworejo periode 2018-2023 dalam menerapkan asas pemilu luber jurdil
Authors: Andriyani Novita , Kuncorowati Puji Wulandar
Published: January 2025

ABSTRAK Penelitian ini bertujuan untuk menganalisis peranan bawaslu Kabupaten Purworejo periode 2018-2023 dalam menerapkan asas pemilu luber jurdil. Penelitian ini menggunakan jenis penelitian deskriptif dengan pendekatan kualitatif. Subjek penelitian ditentukan secara purposive. Subjek dalam penelitian ini terdiri dari koordinator divisi hukum data dan Informasi, koordinator divisi pencegahan partisipasi masyarakat dan hubungan masyarakat, serta koordinator divisi hukum dan penyelesaian sengketa Badan Pengawas Pemilu Kabupaten Purworejo periode 2018-2023. Teknik pengambilan data melalui wawancara dan dokumentasi. Teknik keabsahan data melalui crosscheck data dan analisis data induktif. Hasil penelitian menunjukkan bahwa peranan bawaslu kabupaten Purworejo periode 2018-2023 dalam menerapkan asas pemilu luber jurdil dilakukan melalui (1) sosialisasi, (2) pengawasan pemutakhiran daftar pemilih, (3) sekolah kader pengawas partisipatif, (4) pembentukan saka pemilu adhyasta, (5) sekolah pengawasan pemilu, (6) sosialisasi netralitas ASN, (7) pembentukan desa pengawasan, (8) pengawasan susunan tata letak tempat pemungutan suara (TPS), (9) pembentukan desa anti politik uang, (10) sosialisasi kode etik penyelenggara pemilu, (11) pengawasan pelaksanaan pemilihan umum, (12) penyelesaian sengketa, dan (13) penanganan pelanggaran pemilu.
Pendamping Lokal Desa (PLD) dalam Kinerja dan Peran Pada Program Bantuan Langsung Tunai Dana Desa (BLT DD) Di Desa Keduren Purwodadi Purworejo
Authors: Utami Bella Wulandari , Suharno Suharno
Published: January 2025

Artikel ini ditulis berdasarkan tujuan penelitian yang bertujuan untuk mendeskripsikan kinerja PLD dalam pelaksanaan kebijakan BLT DD di Desa Keduren Purwodadi Purworejo, mendeskripsikan peran PLD dalam penerapan dan pelaksanaan kebijakan program BLT DD di Desa Keduren Purwodadi Purworejo. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif. Subjek penelitian ditentukan dengan menggunakan teknik purposive. Pengumpulan data menggunakan teknik wawancara dan dokumentasi. Analisis keabsahan data dilakukan menggunakan teknik cross check. Analisis data dilakukan secara induktif. Hasil penelitian yang dilaksanakan olehnya adalah bahwa kinerja dan peran PLD dalam progam BLT DD sudah terselenggara dengan baik, dapat dilihat pada: 1) Kinerja PLD dapat dilihat dari tahapan dalam BLT DD yaitu: musyawarah desa atau musdes sekaligus melakukan sosialisasi, melakukan input data lalu menguplodnya ke apikasi Omspan, membuat berita acara, menunggu pencairan dana, mengambil dana, membuat surat undangan bagi penerima BLT DD dan pelaksanaan penyerahan BLT DD. 2) Peran PLD yaitu melalui peran fasilitas, peran teknisi dan peran edukasi. Kinerja PLD dimonitoring dengan aplikasi Monevvedd dan peran PLD dievaluasi dengan aplikasi Lapidum yang dilakukan oleh pendamping desa.
Discovery Learning sebagai Metode Penanaman Disiplin Mata Pelajaran PPKn di MTs Nur Iman Mlangi Sleman
Authors: Hasanah Nur , Marzuki Marzuki
Published: January 2025

ABSTRAKPenelitian ini bertujuan untuk: 1) Mendeskripsikan penanaman disiplin melalui discovery learning mata pelajaran PPKn di MTs Nur Iman Mlangi Sleman; 2) Mengidentifikasi hambatan penanaman disiplin melalui discovery learning mata pelajaran PPKn di MTs Nur Iman Mlangi Sleman; dan 3) Menganalisis upaya mengatasi hambatan penanaman disiplin melalui discovery learning mata pelajaran PPKn di MTs Nur Iman Mlangi Sleman. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif. Teknik pengumpulan data menggunakan metode observasi, wawancara dan dokumentasi. Teknik keabsahan data penelitian dengan Triangulasi Data. Teknik analisis data menggunakan teknik analisis interaktif Miles dan Huberman melalui tahapan reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa 1) Penanaman disiplin melalui discovery learning mata pelajaran PPKn sudah berjalan dengan baik yang mana dilakukan dengan beberapa tahapan yaitu tahap perencanaan, tahap pelaksanaan, dan tahap evaluasi; 2) Hambatan dalam penanaman disiplin melalui discovery learning mata pelajaran PPKn di Mts Nur Iman Mlangi adalah latar belakang pondok pesantren yang berbeda, kurangnya kesadaran diri serta lemahnya keteladanan teman sebaya, dan kurangnya sarana dan prasarana dan 3) Upaya untuk mengatasi hambatan dalam penanaman disiplin melalui discovery learning mata pelajaran PPKn di Mts Nur Iman Mlangi yaitu kerja sama antar komponen sekolah.
UPAYA GURU PPKN SMP NEGERI 3 WONOSARI DALAM MENINGKATKAN MINAT BELAJAR SISWA MELALUI PEMANFAATAN APLIKASI GOOGLE CLASSROOM SEBAGAI MEDIA PEMBELAJARAN
Authors: Paramita Yohana , Suyato Suyato
Published: January 2025

Covid-19 telah menyebabkan sistem pembelajaran yang awalnya dilakukan secara tatap muka ke daring. Pembelajaran daring membutuhkan suatu aplikasi sebagai media untuk belajar sebagai solusi untuk melanjutkan pembelajaran. Penelitian ini bertujuan untuk mengetahui pemanfaatan aplikasi Google Classroom sebagai media pembelajaran, untuk mengetahui faktor pendukung dan penghambat pemanfaatan aplikasi Google Classroom, dan efektivitas pemanfaatan aplikasi Google Classroom dalam meningkatkan minat belajar siswa terhadap pelajaran PPKn di masa pandemi. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif. Tempat penelitian di SMP Negeri 3 Wonosari. Subjek penelitian ditentukan secara purposive. Teknik pengumpulan data melalui wawancara dan analisis dokumentasi. Hasil penelitian menunjukkan bahwa pemanfaatan aplikasi Google Classroom sebagai media pembelajaran dalam meningkatkan minat belajar PPKn pada siswa SMP Negeri 3 Wonosari di masa pandemi sangat baik dan efektif. Peningkatan minat belajar siswa dan keaktifan siswa adalah bukti efektivitas pembelajaran daring. Peningkatan belajar siswa dipengaruhi oleh terpenuhinya fasilitas selama pembelajaran daring seperti kuota dan jaringan internet, komunikasi yang baik, serta kemudahan aplikasi Google Classroom. Sementara kendala yang dihadapi oleh guru adalah tidak bisa mengontrol siswa dan guru dituntut lebih terampil sehingga kelas tidak membosankan. Faktor penghambat dari segi siswa adalah dari fasilitas belajar yang kurang lengkap serta tidak meratanya perekonomian siswa.
Peran Kegiatan Ekstrakurikuler PASUS Terhadap Pembentukan Karakter Siswa di SMA Negeri 3 Cilacap
Authors: Stefani Kale Abella Vania , Sunarso Sunarso
Published: January 2025

Penelitian ini membahas tentang penguatan karakter melalui kegiatan ekstrakurikuler Pasukan Khusus (PASUS) di SMA Negeri 3 Cilacap dalam konteks menumbuhkan sikap nasionalisme dan kedisiplinan. Metode penelitian yang digunakan adalah pendekatan kualitatif dengan jenis studi kasus di SMA Negeri 3 Cilacap. Data dikumpulkan melalui observasi, wawancara, dan dokumentasi, serta dianalisis menggunakan triangulasi data. Hasil penelitian menunjukkan bahwa penguatan karakter nasionalisme dilakukan melalui program pembinaan, penanaman jiwa solidaritas, partisipasi dalam upacara bendera, dan keikutsertaan dalam acara nasional. Hal ini mengubah PASUS menjadi sebuah komunitas yang menerapkan nilai-nilai nasionalisme secara konkret. Sementara itu, penguatan karakter kedisiplinan dilakukan melalui penegakan tata tertib, latihan fisik, pelatihan baris-berbaris, dan partisipasi dalam kegiatan sekolah, yang berasal dari latihan dan sikap hidup yang diterapkan dalam kehidupan sehari-hari. Dampak dari penguatan karakter nasionalisme dan kedisiplinan ini adalah terbentuknya kesetiaan dan cinta tanah air, rasa bangga terhadap bangsa dan negara, serta solidaritas dalam menunjukkan rasa cinta tanah air. Disiplin juga terwujud dalam hal waktu, pemakaian seragam lengkap, dan fisik setiap anggota. Hal ini menghasilkan penguatan karakter yang permanen dan terintegrasi ke dalam identitas individu anggota PASUS, sehingga menciptakan landasan untuk karakter yang kuat dan berkelanjutan.
Pertimbangan Hakim Dalam Menetapkan Dispensasi Perkawinan Dibawah Umur Di Pengadilan Agama Indramayu
Authors: Hilmi Afif Afif Hilmi , Widihastuti Setiati
Published: January 2025

Artikel ini bertujuan untuk mendeskripsikan (1) pertimbangan hakim dalam menetapkan permohonan dispensasi perkawinan dibawah umur di Kabupaten Indramayu (2) pendapat hakim Pengadilan Agama Indramayu terhadap fenomena perkawinan dibawah umur di Kabupaten Indramayu (3) alasan hakim terhadap kecenderungan mengabulkan permohonan dispensasi perkawinan dibawah umur. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif. Subjek penelitian yang terpilih yaitu empat hakim dan satu panitera, dipilih secara purposive. Pengumpulan data dilakukan melalui wawancara dan dokumentasi. Keabsahan data diverikasi dengan cross check dokumentasi dan wawancara. Data dianalisis secara induktif melalui tahap: reduksi, kategorisasi, display, dan verifikasi. Hasilnya pertimbangan hakim terhadap permohonan dispensasi perkawinan mencakup aspek duduk perkara dan aspek hukum. Hakim berpendapat penyebab perkawinan dibawah umur karena kultur atau budaya secara turun temurun, usaha orang tua mengurangi beban ekonomi, risiko perceraian, dan solusi bagi anak yang hamil diluar nikah. Alasan hakim mengabulkan dispensasi perkawinan dibawah umur karena kemanusiaan, kepastian hukum, dan ketertiban hukum di masyarakat.
Pengaruh Penerapan Model Pembelajaran Berbasis Proyek Pada Mata Pelajaran Pendidikan Pancasila Terhadap Kemampuan Berpikir Kritis dan Kreatif Siswa Sekolah Menengah Atas
Authors: Irwanto Oryza Putri , Murdiono Mukhamad
Published: January 2025

Penelitian ini bertujuan untuk mengetahui pengaruh penerapan model pembelajaran berbasis proyek pada mata pelajaran Pendidikan Pancasila terhadap: (1) Kemampuan berpikir kritis siswa SMA; (2) Kemampuan berpikir kreatif siswa SMA; dan (3) Kemampuan berpikir kritis dan kreatif siswa SMA. Jenis penelitian quasi-experimental dengan unit eksperimen meliputi kelas eksperimen yang menerapkan model pembelajaran berbasis proyek dan kelas kontrol yang menerapkan model Discovery Learning. Teknik pengumpulan data melalui observasi dan tes. Analisis data dengan menggunakan analisis statistik deskriptif dan uji hipotesis dengan uji paired sample t-test dan uji Repeated Measures MANOVA melalui uji prasyarat yaitu uji normalitas, uji homogenitas, dan uji sferisitas. Hasil penelitian ini menunjukkan bahwa penerapan model pembelajaran berbasis proyek pada pembelajaran Pendidikan Pancasila: (1) Berpengaruh positif signifikan terhadap kemampuan berpikir kritis siswa SMA. Berdasarkan hasil uji Paired Sample t-Test di kelas eksperimen, bahwa nilai signifikansi (2-tailed) sebesar 0,023 ( 0,05); (2) Berpengaruh positif signifikan terhadap kemampuan berpikir kreatif siswa SMA. Berdasarkan hasil uji Paired Sample t-Test di kelas eksperimen, bahwa nilai signifikansi (2-tailed) sebesar 0,020 ( 0,05); dan (3) Berpengaruh positif signifikan terhadap kemampuan berpikir kritis dan kreatif siswa SMA. Berdasarkan hasil uji Repeated Measures MANOVA di kelas eksperimen, bahwa nilai signifikansi sebesar 0,048 ( 0,05).
THE EFFECT OF UNDERSTANDING THE CONCEPT OF PATRIOTISM AND LEARNING ENVIRONMENT OF MORALITY IN STUDENT LEARNING IN CIVIC EDUCATION IN SMK MUHAMMADIYAH 2 YOGYAKARTA
Authors: Veroza Risky , Samsuri Samsuri
Published: January 2025

ABSTRACT This study aimed to describe Effect of Concept Training Patriotism against Morality Students at SMK Muhammadiyah 2 Yogyakarta, (2) whether there are Influence Learning Environment in Schools about the morality of students in SMK Muhammadiyah 2 Yogyakarta, and(3) whether there are simultaneously influence Patriotism Level concept Training and Learning Environment to Morality Students in Learning Citizenship Education at SMK Muhammadiyah 2 Yogyakarta. This research is a quantitative research. The instrument of this study using objective tests and questionnaires with interval measurement scale with Likert approach, if the data from this study using IBM SPSS program 21. The sample in this study is 10 x 3 variables studied (2 + 1 independent variable dependent variable) of the population. Data collection techniques of research using the technique of principal that comprehension tests and questionnaires, techniques of analysis in this study uses the classical assumption test consisting of test analysis of the distribution of the data, multicollinearity test, test Heteroskedesitas and Hypothesis Testing consists of Test The coefficient of determination (R2), Test F, and T test. The results showed that: (1) there is positive and significant level of understanding of the concept of patriotism against the morality of the students, the value of M statistics obtained t of 3.372 and p = 0.002. Because (3.372 2.051) and p 0.05, then H0 rejected and Ha accepted otherwise, (2) there is a positive and significant impact on the learning environment of the school to the student morality, values obtained t t statistic of 2.221 and p = 0.000. Because (2.221 2.051) and p 0.05, then H0 rejected and Ha accepted otherwise, and (3) there is a simultaneous effect between the level of understanding of the concept of patriotism and learning environment at school for morality SMK Muhammadiyah 2 Yogyakarta, the value of F statistic obtained Fhitung 18.407 and the value of p = 0.000. Because (16.724 3.385) and p 0.05, then H0 rejected and Ha accepted otherwise. Keywords. The Effect Of Understanding The Concept Of Patriotism, Learning Environment, Morality