bluuebunny/crossref_metadata_2025 huggingface dataset:
A PRIM approach to predictive‐signature development for patient stratification
Authors: Chen Gong , Zhong Hua , Belousov Anton , Devanarayan Viswanath
Published: October 2014

Patients often respond differently to a treatment because of individual heterogeneity. Failures of clinical trials can be substantially reduced if, prior to an investigational treatment, patients are stratified into responders and nonresponders based on biological or demographic characteristics. These characteristics are captured by a predictive signature. In this paper, we propose a procedure to search for predictive signatures based on the approach of patient rule induction method. Specifically, we discuss selection of a proper objective function for the search, present its algorithm, and describe a resampling scheme that can enhance search performance. Through simulations, we characterize conditions under which the procedure works well. To demonstrate practical uses of the procedure, we apply it to two real‐world data sets. We also compare the results with those obtained from a recent regression‐based approach, Adaptive Index Models, and discuss their respective advantages. In this study, we focus on oncology applications with survival responses. © 2014 The Authors. Statistics in Medicine published by John Wiley & Sons Ltd.
Near‐Unity Quantum Yields from Chloride Treated CdTe Colloidal Quantum Dots
Authors: Page Robert C. , Espinobarro‐Velazquez Daniel , Leontiadou Marina A. , Smith Charles , Lewis Edward A. , Haigh Sarah J. , Li Chen , Radtke Hanna , Pengpad Atip , Bondino Federica , Magnano Elena , Pis Igor , Flavell Wendy. R. , O'Brien Paul , Binks David J.
Published: October 2014

Colloidal quantum dots (CQDs) are promising materials for novel light sources and solar energy conversion. However, trap states associated with the CQD surface can produce non‐radiative charge recombination that significantly reduces device performance. Here a facile post‐synthetic treatment of CdTe CQDs is demonstrated that uses chloride ions to achieve near‐complete suppression of surface trapping, resulting in an increase of photoluminescence (PL) quantum yield (QY) from ca. 5% to up to 97.2 ± 2.5%. The effect of the treatment is characterised by absorption and PL spectroscopy, PL decay, scanning transmission electron microscopy, X‐ray diffraction and X‐ray photoelectron spectroscopy. This process also dramatically improves the air‐stability of the CQDs: before treatment the PL is largely quenched after 1 hour of air‐exposure, whilst the treated samples showed a PL QY of nearly 50% after more than 12 hours.
Foley balloon catheter to prevent or manage bleeding during treatment for cervical and Cesarean scar pregnancy
Authors: Timor‐Tritsch I. E. , Cali G. , Monteagudo A. , Khatib N. , Berg R. E. , Forlani F. , Avizova E.
Published: October 2014

Objective

To demonstrate the efficacy of placement and inflation of Foley balloon catheters prophylactically to prevent, or as an adjuvant therapy to control, bleeding in women undergoing treatment for Cesarean scar pregnancy (CSP) or cervical pregnancy (CxP).

Methods

This was a retrospective study of 18 women with either CSP (n = 16) or CxP (n = 2), who underwent Foley balloon catheter placement under continuous transvaginal or transabdominal ultrasound guidance to prevent or manage bleeding following treatment, which in most cases comprised local (intragestational sac) and intramuscular (IM) methotrexate (MTX) injections. In eight cases, the balloon catheter was placed immediately following local and/or IM MTX treatment, either because of bleeding or prophylactically; in eight cases, the catheter was placed as part of a two‐step protocol, with patients first treated with local and IM MTX injection, then suction aspiration on Day 4 or 5, followed by planned insertion of a balloon catheter; in one patient the balloon was placed on Day 21 after local and IM MTX treatment, due to sudden bleeding; and in one case of a heterotopic pregnancy, one intrauterine and one cervical, the balloon was placed due to severe bleeding. Human chorionic gonadotropin (hCG) levels were evaluated weekly following MTX injection.

Results

Gestational ages at balloon placement ranged between 5 and 12 + 2 weeks. All embryos/fetuses, with the exception of the cervical heterotopic one, had heart activity and catheter placement was well‐tolerated by all women. The balloon tamponade effectively reduced or prevented maternal vaginal bleeding in all except one patient; this woman had a heterotopic CxP and required abdominal robotic cerclage to control the bleeding. Catheters were kept in place for a mean of 3.6 (range, 1–6) days. hCG levels returned to low or zero levels within 19–82 days following MTX injection. Fifteen women required antibiotic treatment following the procedure. One woman with CSP developed an arteriovenous malformation requiring uterine artery embolization.

Conclusion

Ultrasound‐guided placement and inflation of Foley balloon catheters was easy to perform and well‐tolerated by patients undergoing treatment for CSP or CxP, and successfully prevented or helped in the management of bleeding complications. Based on our experience and previous publications we suggest having the option of balloon catheter insertion available when local treatment of CSP or CxP is undertaken. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd.
Stabilization of Co3 – Oxoclusters in a pcu Net: Synthesis, Structure, Solvent Exchange (Single Crystal to Single Crystal) and Magnetic Studies
Authors: Bhattacharya Saurav , Natarajan Srinivasan
Published: October 2014

The solvothermal reaction of CoCl2·4H2O and 4,4′‐sulfonyldibenzoic acid (H2SDBA) resulted in the formation of a three‐dimensional coordination polymer [Co3(C14H8O6S)3(DMA)2(MeOH)].DMA (Ia) consisting of trinuclear Co3 oxo‐cluster units. The Co3 trimeric units are connected by SDBA2– anions leading to a three dimensional structure with a pcu topology. The terminal methanol molecules could be exchanged in a single crystal to single crystal (SCSC) fashion by other similar solvent molecules (ethanol, acetonitrile, water, ethyleneglycol). Magnetic studies on the parent compound, Ia, indicate antiferromagnetic interactions between the central metal atoms.
Synthesis and Crystal Structure of Mn3(Sb2O2)(VO4)2–x(SbO3)xCl2 (0.08 < x < 0.13), a Vanadium Oxochloride with a VV – SbIII Split Position
Authors: Zimmermann Iwan , Johnsson Mats
Published: October 2014

The compounds Mn3(Sb2O2)(VO4)2–x(SbO3)xCl2 (x = 0.08, 0.10, and 0.13) crystallize in the triclinic space group P$\bar{1}$. The compounds were synthesized through chemical reactions at 550 °C in sealed evacuated silica tubes. The crystal structure is a three‐dimensional framework structure having small channels running along [100]. The manganese oxochloride octahedra [MnO5Cl] and [MnO4Cl2] are connected by edge sharing to form chains that are separated by [VO4], [SbO4], and [SbO3] building blocks. The compound exhibits an unusual split position in between Sb3+ and V5+ so that either [VO4] or [SbO3] form when the two cations replace each other. The Sb/V ratio within the split position has been investigated by measuring three different crystals and the amount of antimony in the split position has shown to vary in the range of 4–6 %.
Genetics Professionals’ Opinions of Whole‐Genome Sequencing in the Newborn Period
Authors: Ulm Elizabeth , Feero W. Gregory , Dineen Richard , Charrow Joel , Wicklund Catherine
Published: October 2014

Newborn screening (NBS) programs have been successful in identifying infants with rare, treatable, congenital conditions. While current programs rely largely on biochemical analysis, some predict that in the future, genome sequencing may be used as an adjunct. The purpose of this exploratory pilot study was to begin to characterize genetics professionals’ opinions of the use of whole‐genome sequencing (WGS) in NBS. We surveyed members of the American College of Medical Genetics and Genomics (ACMG) via an electronic survey distributed through email. The survey included questions about results disclosure, the current NBS paradigm, and the current criteria for adding a condition to the screening panel. The response rate was 7.3 % (n = 113/1549). The majority of respondents (85 %, n = 96/113) felt that WGS should not be currently used in NBS, and that if it were used, it should not be mandatory (86.5 %, n = 96/111). However, 75.7 % (n = 84/111) foresee it as a future use of WGS. Respondents felt that accurate interpretation of results (86.5 %, n = 83/96), a more extensive consent process (72.6 %, n = 69/95), pre‐ (79.2 %, n = 76/96) and post‐test (91.6 %, n = 87/95) counseling, and comparable costs (70.8 %, n = 68/96) and turn‐around‐times (64.6 %, n = 62/96) to current NBS would be important for using WGS in NBS. Participants were in favor of disclosing most types of results at some point in the lifetime. However, the majority (87.3 %, n = 96/110) also indicated that parents should be able to choose what results are disclosed. Overall, respondents foresee NBS as a future use of WGS, but indicated that WGS should not occur within the framework of traditional NBS. They agreed with the current criteria for including a condition on the recommended uniform screening panel (RUSP). Further discussion about these criteria is needed in order to better understand how they could be utilized if WGS is incorporated into NBS.
Recreational fisheries in the USA: economics, management strategies, and ecological threats
Authors: Hughes Robert M.
Published: October 2014

Recreational fishing has a long history in the USA, developing from the subsistence fisheries of Native Americans together with a partial subsistence fishery of later immigrants. Marine, diadromous, and aquatic taxa are targeted, including both vertebrates and macroinvertebrates. This paper defines recreational fishing, describes the main fishing techniques, identifies target taxa by region, summarizes the socio-economic values of recreational fishing, and discusses management strategies and major ecological threats.
MiR‐185 is involved in human breast carcinogenesis by targeting Vegfa
Authors: Wang Rui , Tian Shi , Wang Hong-Bin , Chu Da-Peng , Cao Jing-Li , Xia Hong-Fei , Ma Xu
Published: October 2014

MiR‐185 expression has been associated with many cancers. However, the roles of miR‐185 in human breast cancer remain elusive. Here, we found that miR‐185 expression was decreased in human breast cancer tissues compared with healthy tissue controls. Up‐regulation of miR‐185 inhibited breast cancer cell proliferation and invasion and vice versa. MiR‐185 was shown to bind to the 3′‐untranslated region (UTR) of vascular endothelial growth factor a (Vegfa), and a significant inverse correlation was found between miR‐185 and Vegfa. Vegfa overexpression partially restored the inhibition of cell proliferation and invasion that was induced by miR‐185, and vice versa. Additionally, Vegfa expression was found to be high in human breast cancer tissues. Thus, miR‐185‐mediated Vegfa targeting may be involved in breast cancer formation.
MiR‐199a‐3p promotes gastric cancer progression by targeting ZHX1
Authors: Wang Zhenqiang , Ma Xingjie , Cai Qiang , Wang Xinjing , Yu Beiqin , Cai Qu , liu Bingya , Zhu Zhenggang , Li Chen
Published: October 2014

Accumulating evidence has indicated that microRNAs (miRNAs) act as critical epigenetic regulators in tumor carcinogenesis. Here, we report that miR‐199a‐3p was significantly upregulated in gastric cancer (GC) cell lines and tissues. Functional studies demonstrated that miR‐199a‐3p dramatically increased cell proliferation and suppressed cell apoptosis both in vitro and in vivo. Furthermore, the transcriptional regulator zinc fingers and homeoboxes 1 (ZHX1) was identified as one of the direct downstream targets of miR‐199a‐3p, miR‐199a‐3p bound to the ZHX1 3′ untranslated region (3′UTR) to regulate ZHX1 protein expression. In addition, the expression of miR‐199a‐3p was inversely associated with that of ZHX1 in GC cell lines. Overexpression of miR‐199a‐3p in SGC‐7901 cells inhibited ZHX1 expression, while reduction in miR‐199a‐3p by inhibitors in NCI‐N87 cells enhanced ZHX1 expression. Moreover, restoring ZHX1 expression in SGC‐7901/miR‐199a‐3p cells inhibited the cell proliferation induced by miR‐199a‐3p. Taken together, these findings suggest that miR‐199a‐3p may function as a novel tumor promoter in GC and its oncogenic activity may involve the direct targeting and inhibition of ZHX1.
Time-resolved evolution of coherent structures in turbulent channels: characterization of eddies and cascades
Authors: Lozano-Durán Adrián , Jiménez Javier
Published: October 2014

A novel approach to the study of the kinematics and dynamics of turbulent flows is presented. The method involves tracking in time coherent structures, and provides all of the information required to characterize eddies from birth to death. Spatially and temporally well-resolved DNSs of channel data at $\mathit{Re}_{{\it\tau}}=930{-}4200$ are used to analyse the evolution of three-dimensional sweeps, ejections (Lozano-Durán et al., J. Fluid Mech., vol. 694, 2012, pp. 100–130) and clusters of vortices (del Álamo et al., J. Fluid Mech., vol. 561, 2006, pp. 329–358). The results show that most of the eddies remain small and do not last for long times, but that some become large, attach to the wall and extend across the logarithmic layer. The latter are geometrically and temporally self-similar, with lifetimes proportional to their size (or distance from the wall), and their dynamics is controlled by the mean shear near their centre of gravity. They are responsible for most of the total momentum transfer. Their origin, eventual disappearance, and history are investigated and characterized, including their advection velocity at different wall distances and the temporal evolution of their size. Reinforcing previous results, the symmetry found between sweeps and ejections supports the idea that they are not independent structures, but different manifestations of larger quasi-streamwise rollers in which they are embedded. Spatially localized direct and inverse cascades are respectively associated with the splitting and merging of individual structures, as in the models of Richardson (Proc. R. Soc. Lond. A, vol. 97(686), 1920, pp. 354–373) or Obukhov (Izv. Akad. Nauk USSR, Ser. Geogr. Geofiz., vol. 5(4), 1941, pp. 453–466). It is found that the direct cascade predominates, but that both directions are roughly comparable. Most of the merged or split fragments have sizes of the order of a few Kolmogorov viscous units, but a substantial fraction of the growth and decay of the larger eddies is due to a self-similar inertial process in which eddies merge and split in fragments spanning a wide range of scales.
Large eddy simulation of flow over a twisted cylinder at a subcritical Reynolds number
Authors: Jung Jae Hwan , Yoon Hyun Sik
Published: October 2014

We consider a twisted cylinder that was designed by rotating the elliptic cross-section along the spanwise direction, resulting in a passive control. The flow over the twisted cylinder is investigated at a subcritical Reynolds number (Re) of 3000 using large eddy simulation based on the finite volume method. For comparison, the flow past smooth and wavy cylinders is also calculated. The twisted cylinder achieves reductions of approximately 13 and 5 % in mean drag compared with smooth and wavy cylinders, respectively. In particular, the root mean square (r.m.s.) value of the lift fluctuation of the twisted cylinder shows a substantial decrease of approximately 96 % compared with the smooth cylinder. The shear layer of the twisted cylinder covering the recirculation region is more elongated than those of the smooth and wavy cylinders, and vortex shedding from the twisted cylinder is considerably suppressed. Consequently, the elongation of the shear layer from the body and the near disappearance of vortex shedding in the near wake with weak vortical strength contributes directly to the reduction of drag and lift oscillation. Various fundamental mechanisms that affect the flow phenomena, three-dimensional separation, pressure coefficient, vortex formation length and turbulent kinetic energy are examined systematically to demonstrate the effect of the twisted cylinder surface. In addition, for the twisted cylinder at$\mathit{Re}=3000$, the effect of the cross-sectional aspect ratio is investigated from 1.25 to 2.25 to find an optimal value that can reduce the drag and lift forces. Moreover, the effect of the Reynolds number on the aerodynamic characteristics is investigated in the range of$3\times 10^{3}\leqslant \mathit{Re}\leqslant 1\times 10^{4}$. We find that asReincreases, the mean drag and the r.m.s. lift coefficient of the twisted cylinder increase, and the vortex formation length decreases.
Fully nonlinear long-wave models in the presence of vorticity
Authors: Castro Angel , Lannes David
Published: October 2014

We study here Green–Naghdi type equations (also called fully nonlinear Boussinesq, or Serre equations) modelling the propagation of large-amplitude waves in shallow water without a smallness assumption on the amplitude of the waves. The novelty here is that we allow for a general vorticity, thereby allowing complex interactions between surface waves and currents. We show that the a priori ($2+1$)-dimensional dynamics of the vorticity can be reduced to a finite cascade of two-dimensional equations. With a mechanism reminiscent of turbulence theory, vorticity effects contribute to the averaged momentum equation through a Reynolds-like tensor that can be determined by a cascade of equations. Closure is obtained at the precision of the model at the second order of this cascade. We also show how to reconstruct the velocity field in the ($2+1$)-dimensional fluid domain from this set of two-dimensional equations and exhibit transfer mechanisms between the horizontal and vertical components of the vorticity, thus opening perspectives for the study of rip currents, for instance.
Is there a linear relationship between the dose of ruminanttrans-fatty acids and cardiovascular risk markers in healthy subjects: results from a systematic review and meta-regression of randomised clinical trials
Authors: Gayet-Boyer Constance , Tenenhaus-Aziza Fanny , Prunet Caroline , Marmonier Corinne , Malpuech-Brugère Corinne , Lamarche Benoit , Chardigny Jean-Michel
Published: October 2014

The effects of ruminant (R)trans-fatty acids (TFA) on the risk of CVD are still under debate. It could be argued that the lack of the effect of R-TFA may be the result of the small amount of their intake. Taking into consideration the growing available data from intervention studies, we carried out a systematic review and meta-regression to assess the impact of R-TFA intake levels on changes in the total cholesterol: HDL-cholesterol (TC:HDL-C) ratio. A systematic review of the literature was conducted and thirteen randomised clinical trials were included, yielding a total of twenty-three independent experimental groups of subjects. A univariate random-effects meta-regression approach was used to quantify the relationship between the dose of R-TFA and changes in the TC:HDL-C ratio. To consider several potential modifiers such as subject and dietary characteristics, a multivariate regression analysis was performed. We found no relationship between R-TFA intake levels of up to 4·19 % of daily energy intake (EI) and changes in cardiovascular risk factors such as TC:HDL-C and LDL-cholesterol (LDL-C):HDL-C ratios. In addition, a multivariate regression analysis that included other dietary variables, as well as subject baseline characteristics, confirmed that doses of R-TFA did not significantly influence the changes in the lipid ratio. Our findings showed that doses of R-TFA did not influence the changes in the ratios of plasma TC:HDL-C and LDL-C:HDL-C. These data suggest that TFA from natural sources, at least at the current levels of intake and up to 4·19 % EI, have no adverse effects on these key CVD risk markers in healthy people.
A dietary pattern rich in lignans, quercetin and resveratrol decreases the risk of oesophageal cancer
Authors: Lin Yulan , Yngve Agneta , Lagergren Jesper , Lu Yunxia
Published: October 2014

Dietary lignans, quercetin and resveratrol have oestrogenic properties, and animal studies suggest that they synergistically decrease cancer risk. A protective effect of lignans on the development of oesophageal cancer in humans has recently been demonstrated, and the present study aimed to test whether these three phytochemicals synergistically decrease the risk of oesophageal cancer. Data from a Swedish nationwide population-based case–control study that recruited 181 cases of oesophageal adenocarcinoma (OAC), 158 cases of oesophageal squamous-cell carcinoma (OSCC), 255 cases of gastro-oesophageal junctional adenocarcinoma (JAC) and 806 controls were analysed. Exposure data were collected through face-to-face interviews and questionnaires. The intake of lignans, quercetin and resveratrol was assessed using a sixty-three-item FFQ. Reduced-rank regression was used to assess a dietary pattern, and a simplified dietary pattern score was categorised into quintiles on the basis of the distribution among the control subjects. Unconditional multivariable logistic regression provided OR with 95 % CI, adjusted for all the potential risk factors. A dietary pattern rich in lignans, quercetin and resveratrol was mainly characterised by a high intake of tea, wine, lettuce, mixed vegetables, tomatoes, and whole-grain bread and a low intake of milk. There were dose-dependent associations between simplified dietary pattern scores and all types of oesophageal cancer (all P for trend < 0·05). On comparing the highest quintiles with the lowest, the adjusted OR were found to be 0·24 (95 % CI 0·12, 0·49) for OAC, 0·31 (95 % CI 0·15, 0·65) for OSCC, and 0·49 (95 % CI 0·28, 0·84) for JAC. The results of the present study indicate that a dietary pattern characterised by the intake of lignans, quercetin and resveratrol may play a protective role in the development of oesophageal cancer in the Swedish population.
Impact of cafeteria feeding during lactation in the rat on novel object discrimination in the offspring
Authors: Wright Thomas M. , King Madeleine V. , Davey William G. , Langley-Evans Simon C. , Voigt Jörg-Peter W.
Published: October 2014

There is increasing evidence that hyperenergetic diets have an impact on memory in rodents. However, it is largely unknown how diets, such as a cafeteria diet (CD), that mimic a Western-type diet act on learning and memory, in particular when fed during early stages of development. Here, we fed lactating dams a CD and exposed both male and female offspring to a novel object discrimination (NOD) task, a two-trial test of recognition memory in which rats exposed to two identical objects during a training/familiarisation trial can discriminate a novel from a familiar object during the subsequent choice trial. The choice trial was performed following inter-trial interval (ITI) delays of up to 4 h. Maternal diet did not have an impact on exploration of the objects by either sex during the familiarisation trial. Control males discriminated the novel from the familiar object, indicating intact memory with an ITI of 1 h, but not 2 or 4 h. The CD delayed this natural forgetting in male rats such that discrimination was also evident after a 2 h ITI. In contrast, control females exhibited discrimination following both 1 and 2 h ITI, but the CD impaired performance. In summary, the present study shows that maternal exposure to the CD programmes NOD in the adult. In better-performing females, dietary programming interferes with NOD, whereas NOD was improved in males after lactational CD feeding.
A Frostman-Type Lemma for Sets with Large Intersections, and an Application to Diophantine Approximation
Authors: Persson Tomas , Reeve Henry W. J.
Published: October 2014

We consider classes of subsets of [0, 1], originally introduced by Falconer, that are closed under countable intersections, and such that every set in the class has Hausdorff dimension at least s. We provide a Frostman-type lemma to determine if a limsup set is in such a class. Suppose that E = lim sup En ⊂ [0, 1], and that μn are probability measures with support in En. If there exists a constant C such that

for all n, then, under suitable conditions on the limit measure of the sequence (μn), we prove that the set E is in the class .

As an application we prove that, for α > 1 and almost all λ ∈ (½, 1), the set

where and ak ∈ {0, 1}}, belongs to the class . This improves one of our previously published results.
On Nonlinear Boundary Conditions Involving Decomposable Linear Functionals
Authors: Goodrich Christopher S.
Published: October 2014

In this paper we consider the existence of a positive solution to boundary-value problems with non-local nonlinear boundary conditions, the archetypical example being −y″(t) = λf(t,y(t)),t∈ (0, 1),y(0) =H(φ(y)),y(1) = 0. Here,His a nonlinear function,λ> 0 is a parameter andφis a linear functional that is realized as a Lebesgue—Stieltjes integral with signed measure. By requiringφto decompose in a certain way, we show that this problem has at least one positive solution for eachλ∈ (0,λ0), for a numberλ0> 0 that is explicitly computable. We also give a separate result that holds for allλ> 0.
Equivariant Compactifications of Two-Dimensional Algebraic Groups
Authors: Derenthal Ulrich , Loughran Daniel
Published: October 2014

We classify generically transitive actions of semi-direct products on ℙ2. Motivated by the program to study the distribution of rational points on del Pezzo surfaces (Manin's conjecture), we determine all (possibly singular) del Pezzo surfaces that are equivariant compactifications of homogeneous spaces for semi-direct products .
Locating the locale of local food: The importance of context, space and social relations
Authors: Carroll Brídín E. , Fahy Frances
Published: October 2014

Localization is one process/outcome that is proffered as key to the ‘grand challenges’ that currently face the food system. Consumers are attributed much agency in this potential transformation, being encouraged from all levels of society to exert their consumer muscle by buying local food. However, due to the social construction of scale it cannot be said that ‘local food’ is a definite entity and consumers understand the term ‘local food’ differently depending on their geographic and social context. As such, the research upon which this paper is based aimed to provide a nuanced understanding of how consumers in the particular spatial and social contexts of urban and rural Ireland understood the concept of ‘local food’. A specific objective was to test the theory that these consumers may have fallen into the ‘local trap’ by unquestioningly associating food from a spatially proximate place with positive characteristics. A three-phase mixed methodology was undertaken with a sample of consumers dwelling in urban and rural areas in both Dublin and Galway, Ireland: 1000 householders were surveyed; 6 focus group discussions took place; and 28 semi-structured interviews were carried out. The results presented in this paper indicate that for most participants in this study, spatial proximity is the main parameter against which the ‘localness’ of food is measured. Also, it was found that participants held multiple meanings of local food and there was a degree of fluidity in their understandings of the term. The results from the case study regions highlight how participants’ understandings of local food changed depending on the food in question and its availability. However, the paper also indicates that as consumers move from one place to another, the meaning of local food becomes highly elastic. The meaning is stretched or contracted according to the perceived availability of food, greater or lesser connections to the local producer community and the relative geographic size of participants’ locations. Our analysis of findings from all three phases of this research revealed a difference in understandings of local food among participants resident in urban and rural areas: participants dwelling in rural areas were more likely than those in urban areas to define local food according to narrower spatial limits. The paper concludes with an overview of the practical and theoretical significance of these results in addressing the current dearth of research exploring the meaning of local food for consumers and suggests avenues for future research.
Home equity release for long-term care financing: an improved market structure and pricing approach
Authors: Andrews Doug , Oberoi Jaideep
Published: October 2014

Home equity release products have been promoted as a potential solution to residential long-term care costs for the elderly. Lower than expected utilisation of home equity release loans has prompted efforts to better model and price the no-negative-equity-guarantee (NNEG) built into the contracts, but loan rates are still widely perceived by homeowners as being unattractive. We propose the introduction of a new adjustable rate loan based on a regional house price index, with the NNEG being borne by a specially created intermediary. The proposed approach allows us to directly address and separately price the basis risk between individual house price returns and index returns. In addition, it offers the opportunity to create securities based on residential real estate that would be attractive to a wider class of investors. The alternative risk-sharing mechanism creates a more transparent and simple pricing structure for the loans. We then use house sales data to demonstrate the approach. We find in our sample that it would be possible to make higher loans than seen in previous literature using standard roll-up contracts. In the most favourable scenario for our simulations, the maximum loan is 89% of the appraised home value if the loan is advanced as a lump sum and 95% if the loan is advanced in instalments.
An Emerging Opportunity for Pediatric Psychologists: Our Role in a Multidisciplinary Clinic for Youth With Gender Dysphoria
Authors: Cousino Melissa K. , Davis Ajuah , Ng Henry , Stancin Terry
Published: October 2014

An increasing number of youth are identifying themselves as gender variant (e.g., transgender) or nonconforming with culturally defined biological sex-based norms. Children with persistent gender dysphoria (GD) are at risk for psychological distress; subsequently, there has been a rise in the number of families, schools, and health-care providers seeking mental health services and advice regarding medical interventions for youth experiencing significant GD. Pediatric psychologists are well positioned to fulfill this need given their expertise in child development and child emotional and behavioral functioning in addition to their experiences working alongside medical teams and with patients undergoing medical treatments. This article describes the development and implementation of a hospital-based multidisciplinary clinic for gender-variant youth. Particular emphasis is paid to the role of the pediatric psychologist within the clinic. A case example is illustrated. Obstacles and future directions for pediatric psychologists working in this area are highlighted.
Carolyn S. Schroeder Award for Outstanding Clinical Practice: Creativity and Innovation in the Practice of Pediatric Psychology
Authors: Carter Bryan D.
Published: October 2014

Translating evidence-based treatments into real world clinical practice requires the application of creativity, clinical skills, and interpersonal engagement. This involves being attuned to our patients, colleagues, and mentors as sources of inspiration while continually nurturing oneself throughout the career life span. The author, the 2014 recipient of the Division 54 Carolyn S. Schroeder Award for Clinical Practice, provides suggestions for and examples of engaging creativity and innovation in the service of providing evidence-based interventions with patients and families.
Laterally spreading iron, humic-like dissolved organic matter and nutrients in cold, dense subsurface water of the Arctic Ocean
Authors: Hioki Nanako , Kuma Kenshi , Morita Yuichirou , Sasayama Ryouhei , Ooki Atsushi , Kondo Yoshiko , Obata Hajime , Nishioka Jun , Yamashita Youhei , Nishino Shigeto , Kikuchi Takashi , Aoyama Michio
Published: October 2014

The location and magnitude of oceanic iron sources remain uncertain owing to a scarcity of data, particularly in the Arctic Ocean. The formation of cold, dense water in the subsurface layer of the western Arctic Ocean is a key process in the lateral transport of iron, macronutrients and other chemical constituents. Here, we present iron, humic-like fluorescent dissolved organic matter and nutrient concentration data in waters above the continental slope and shelf and along two transects across the shelf–basin interface in the western Arctic Ocean. We detected high concentrations in shelf bottom waters and in a plume that extended in the subsurface cold dense water of the halocline layer in slope and basin regions. At σθ = 26.5, dissolved Fe, humic-like fluorescence intensity and nutrient maxima coincided with N* minima (large negative values of N* indicate significant denitrification within shelf sediments). These results suggest that these constituents are supplied from the shelf sediments and then transported laterally to basin regions. Humic dissolved organic matter probably plays the most important role in the subsurface maxima and lateral transport of dissolved Fe in the halocline layer as natural Fe-binding organic ligand.
The breakthrough curve combination for xenon sampling dynamics in a carbon molecular sieve column
Authors: Shu-jiang Liu , Zhan-ying Chen , Yin-zhong Chang , Shi-lian Wang , Qi Li , Yuan-qing Fan , Huai-mao Jia , Xin-jun Zhang , Yun-gang Zhao
Published: October 2014

In the research of xenon sampling and xenon measurements, the xenon breakthrough curve plays a significant role in the xenon concentrating dynamics.
Reversible capping/uncapping of phosphorous-centered Keggin-type polyoxoniobate clusters
Authors: Son Jung-Ho , Casey William H.
Published: October 2014

Caps in α-Keggin-type polyoxometalates [PM2Nb12O40]9− (M: NbO or VO) can be removed in basic condition to produce uncapped [PNb12O40]15−. Transmetalation or capping occurs from the reaction of [PNb14O42]9− or [PNb12O40]15− with either Sb2O3 or V2O5 to form [PSb2Nb12O40]9− or [PV2Nb12O42]9−, respectively.
In situ Raman monitoring of [2+2] cycloaddition of pyridine substituted olefins induced by visible laser
Authors: Chen Dengtai , Han Xijiang , Jin Wen , Du Yunchen , Xu Ping
Published: October 2014

Visible laser induced [2+2] cycloaddition of solid-state pyridine substituted olefins into cyclobutane can be monitored by an in situ Raman technique.
A general approach for the development of fluorogenic probes suitable for no-wash imaging of kinases in live cells
Authors: Zhang Qing , Liu Hui , Pan Zhengying
Published: October 2014

A general approach is presented for developing small molecule-based fluorogenic probes suitable for no-wash imaging of endogenous kinases in live cells.
A highly luminescent and highly oxygen-sensitive Tb(iii) complex with a tris-aryloxide functionalised 1,4,7-triazacyclononane ligand
Authors: Nakai Hidetaka , Goto Takahiro , Kitagawa Kazuhiro , Nonaka Kyoshiro , Matsumoto Takahiro , Ogo Seiji
Published: October 2014

This communication presents a new terbium(iii) complex that shows the highest luminescence quantum yield among the oxygen-sensitive lanthanide complexes.
Fluoride, bifluoride and trifluoromethyl complexes of iridium(i) and rhodium(i)
Authors: Truscott Byron J. , Nahra Fady , Slawin Alexandra M. Z. , Cordes David B. , Nolan Steven P.
Published: October 2014

New methods for the preparation of a range of NHC-based Ir(i) and Rh(i) fluoride, bifluoride and trifluoromethyl complexes are reported.
Fe3O4@TiO2preparation and catalytic activity in heterogeneous photocatalytic and ozonation processes
Authors: Ciccotti L. , do Vale L. A. S. , Hewer T. L. R. , Freire R. S.
Published: October 2014

Systematic evaluation of experimental variables in magnetic nanoparticle preparation and hybrid catalyst application in the heterogeneous catalytic ozonation process.
Temperature variable luminescence and color tuning of Eu2+/Mn2+-codoped strontium magnesium phosphates as promising red-emitting phosphors for light emitting diodes
Authors: Yun Young Jun , Lim Hee Jeong , Park Jin-Seong , Wu Mihye , Jung Ha-Kyun , Choi Sungho
Published: October 2014

Color tuning with temperature variable luminescence of Eu2+ and Mn2+ codoped violet-/red-emitting strontium magnesium phosphates, SrMgP2O7, SrMg2P2O8 and Sr2Mg3P4O15, was investigated.
Assembly of three coordination polymers based on a sulfonic–carboxylic ligand showing high proton conductivity
Authors: Zhao Shu-Na , Song Xue-Zhi , Zhu Min , Meng Xing , Wu Lan-Lan , Song Shu-Yan , Wang Cheng , Zhang Hong-Jie
Published: October 2014

Three MOFs with different structures all exhibit proton conduction behavior, especially for the Cu compound with a proton conductivity of 3.46 × 10−3 S cm−1 at 368 K and 95% RH.
Breaking aggregation in a tetrathiafulvalene-fused zinc porphyrin by metal–ligand coordination to form a donor–acceptor hybrid for ultrafast charge separation and charge stabilization
Authors: Jana Atanu , Gobeze Habtom B. , Ishida Masatoshi , Mori Toshiyuki , Ariga Katsuhiko , Hill Jonathan P. , D'Souza Francis
Published: October 2014

A novel electron rich, tetrathiafulvalene fused zinc porphyrin, (TTF)4PZn, has been newly synthesized and characterized using spectral and electrochemical methods.
The effect on structural and solvent water molecules of substrate binding to ferric horseradish peroxidase
Authors: Simpson Niall , Adamczyk Katrin , Hithell Gordon , Shaw Daniel J. , Greetham Gregory M. , Towrie Michael , Parker Anthony W. , Hunt Neil T.
Published: October 2014

Ultrafast, multi-dimensional infrared spectroscopy, in the form of 2D-IR and pump–probe measurements, has been employed to investigate the effect of substrate binding on the structural dynamics of the horseradish peroxidase (HRP) enzyme. Using nitric oxide bound to the ferric haem of HRP as a sensitive probe of local dynamics, we report measurements of the frequency fluctuations (spectral diffusion) and vibrational lifetime of the NO stretching mode with benzohydroxamic acid (BHA) located in the substrate-binding position at the periphery of the haem pocket, in both D2O and H2O solvents. The results reveal that, with BHA bound to the enzyme, the local structural dynamics are insensitive to H/D exchange. These results are in stark contrast to those found in studies of the substrate-free enzyme, which demonstrated that the local chemical and dynamic environment of the haem ligand is influenced by water molecules. In light of the large changes in solvent accessibility caused by substrate binding, we discuss the potential for varying roles for the solvent in the haem pocket of HRP at different stages along the reaction coordinate of the enzymatic mechanism.
Excited state dynamics of organic semi-conducting materials
Authors: Ghiggino Kenneth P. , Tilley Andrew J. , Robotham Benjamin , White Jonathan M.
Published: October 2014

Time-resolved absorption and emission spectroscopy has been applied to investigate the dynamics of excited state processes in oligomer models for semi-conducting organic materials. Following the photo-excitation of a pentamer oligomer that is a model for the conjugated polymer MEH-PPV, an ultrafast component of a few picoseconds is observed for the decay of the initially formed transient species. Variable temperature absorption and emission spectra combined with X-ray crystallography and calculations support the assignment of this rapid relaxation process to an excited state conformational rearrangement from non-planar to more planar molecular configurations. The implications of the results for the overall photophysics of conjugated polymers are considered.
Effects of the MoO3 structure of Mo–Sn catalysts on dimethyl ether oxidation to methyl formate under mild conditions
Authors: Liu Guangbo , Zhang Qingde , Han Yizhuo , Tsubaki Noritatsu , Tan Yisheng
Published: October 2014

The effects of the Sn content on the structure of MoO3 in MoO3–SnO2 catalysts.
Novel fluorescence resonance energy transfer optical sensors for vitamin B12 detection using thermally reduced carbon dots
Authors: Wang Jilong , Wei Junhua , Su Siheng , Qiu Jingjing
Published: October 2014

After thermal reduction, the quantum yield of thermally reduced carbon dots demonstrated a 5-fold increase over that of the original carbon dots.
A strategic approach to the synthesis of functionalized spirooxindole pyrrolidine derivatives: in vitro antibacterial, antifungal, antimalarial and antitubercular studies
Authors: Haddad Saoussen , Boudriga Sarra , Akhaja Tarunkumar Nanjibhai , Raval Jignesh Priyakant , Porzio François , Soldera Armand , Askri Moheddine , Knorr Michael , Rousselin Yoann , Kubicki Marek M. , Rajani Dhanji
Published: October 2014

A series of spirooxindole pyrrolidine derivatives has been synthesized and evaluated for theirin vitrobiological activities. The observed regio- and stereoselectivity of the cycloaddition reaction has been rationalized using DFT calculations.
Study on the interaction of (+)-catechin with human serum albumin using isothermal titration calorimetry and spectroscopic techniques
Authors: Li Xiangrong , Wang Su
Published: October 2014

The quantitative information of (+)-catechin and HSA interaction provides a firm basis for its rational use in clinical practice.
Recent advances in ginseng as cancer therapeutics: a functional and mechanistic overview
Authors: Wong Alice S. T. , Che Chi-Ming , Leung Kar-Wah
Published: October 2014

This review covers recent research advances in elucidating the anti-cancer mechanisms of ginsenosides and their potential clinical applications.
A peptide topological template for the dispersion of [60]fullerene in water
Authors: Bartocci S. , Mazzier D. , Moretto A. , Mba M.
Published: October 2014

Stable dispersions of [60]fullerene in water with concentrations of up to 1.3 mg mL−1 have been obtained using a peptide topological template as the carrier.
Effect of monomers’ structure on self-acid-assisted polycondensation for the synthesis of poly(3,4-ethylenedioxythiophene) and homopolythiophene
Authors: Tusy Chuong , Jiang Kang , Peng Kai , Huang Lili , Xia Jiangbin
Published: October 2014

PEDOT and homopolythiophene were synthesized by self-acid-assisted polycondensation (SAAP) based on mono-halogen substituted thiophene derivative monomers. Our results reveal that substituted halogen (bromo or iodo) positions play an important role in SAAP.
Ionic liquids as recyclable and separable reaction media in Rh-catalyzed decarbonylation of aromatic and aliphatic aldehydes
Authors: Malcho Phillip , García-Suárez Eduardo J. , Riisager Anders
Published: October 2014

Ionic liquids (ILs) have been applied as recyclable reaction media in the decarbonylation of aldehydes in the presence of a rhodium–phosphine complex catalyst.
Novel fluorescent security marker. Part II: application of novel 6-alkoxy-2-amino-3,5-pyridinedicarbonitrile nanoparticles in safety paper
Authors: Basta Altaf , Missori Mauro , Girgis Adel S. , De Spirito Marco , Papi Massimiliano , El-Saied Houssni
Published: October 2014

Application of newly synthesized fluorescent nanoparticles of 6-alkoxy-2-amino-3,5-pyridinedicarbonitriles as security markers for enhancing the safety property of bagasse-based paper sheets (as valuable documents) was studied.”.
Partially embedded gold nanoislands in a glass substrate for SERS applications
Authors: Yaseen Mohammad Tariq , Chen Minfeng , Chang Yia-Chung
Published: October 2014

We investigate the surface enhanced Raman scattering (SERS) of biomolecules attached to partially embedded gold nanoislands in a transparent substrate.
Sensitive and easily recyclable plasmonic SERS substrate based on Ag nanowires in mesoporous silica
Authors: Yan Xuefeng , Wang Lingzhi , Qi Dianyu , Lei Juying , Shen Bin , Sen Tapas , Zhang Jinlong
Published: October 2014

Parallel aligned Ag nanowires in SBA-15 present high SERS sensitivity due to improved plasmonic coupling effect. The further utilization of reversible conversion reaction between Ag and AgCl makes this SERS substrate easily renewable.
Structural evolution, sequential oxidation and chemical bonding in tri-yttrium oxide clusters: Y3Ox− and Y3Ox (x = 0–6)
Authors: Xu Lei , Xia Chan-Juan , Wang Ling-Fei , Xie Lu , Wang Bin , Zhang Yong-Fan , Huang Xin
Published: October 2014

The evolution of regularities for Y3Ox−/0 (x = 0–6) and all-metal aromaticity of the Y3− cluster have been discovered.
Filipins: the first antifungal “weed killers” identified from bacteria isolated from the trap-ant
Authors: Gao Hong , Grüschow Sabine , Barke Jörg , Seipke Ryan F. , Hill Lionel M. , Orivel Jérôme , Yu Douglas W. , Hutchings Matthew , Goss Rebecca J. M.
Published: October 2014

Allomerus ants cultivate fungus to fabricate their insect traps. Speculation is that the ants employ actinomycetes to help achieve fungal monoculture. From an associated actinomycete we identify the first antifungal compounds and encoding genes.
Anion transfer across “anion channels” at the liquid/liquid interface modified by anion-exchange membrane
Authors: Hu Daopan , Wang Huanhuan , Gao Kui , Jiang Xuheng , Wang Meng , Long Yafeng , Chen Yong
Published: October 2014

A novel strategy is proposed to mimic anion channels and study anion transfer reactions at the water/1,2-dichloroethane (W/DCE) interface modified by a homogeneous anion-exchange membrane (AEM).
One-pot solvothermal synthesis of singly doped Eu3+ and codoped Er3+, Yb3+ heavy rare earth oxysulfide Y2O2S nano-aggregates and their luminescence study
Authors: Liu Hong , Liu Ping , Su Xiangming , Liu Jie , Li Xiaoqing , Luo Hongde , Yao Zhiling , Yu Xibin , Zhan Ming
Published: October 2014

Highly crystallized micro/nano-sized Y2O2S were prepared through a one-pot mild solvothermal synthesis. By simply adjusting the amount of initial sulfur powder, the morphology and assembled structures can be well controlled.
Mesopattern of immobilised bone morphogenetic protein-2 created by microcontact printing and dip-pen nanolithography influence C2C12 cell fate
Authors: Oberhansl S. , Castaño A. G. , Lagunas A. , Prats-Alfonso E. , Hirtz M. , Albericio F. , Fuchs H. , Samitier J. , Martinez E.
Published: October 2014

Making meso matter: bone morphogenetic protein-2 (BMP-2) mesopattern created by dip-pen nanolithography and microcontact printing were applied to cell differentiation.
Turning the chitosan surface from hydrophilic to hydrophobic by layer-by-layer electro-assembly
Authors: Ye Jia-Ru , Chen Li , Zhang Yi , Zhang Qi-Chen , Shen Qing
Published: October 2014

By employing an electrostatic generator to enhance or reduce the van der Waals force in a novel layer-by-layer electro-assembly process, this work proves that the chitosan surface can be prepared with tunable wettability, e.g. from hydrophilic to hydrophobic.
POSS-based luminescent porous polymers for carbon dioxide sorption and nitroaromatic explosives detection
Authors: Wang Dengxu , Li Liguo , Yang Wenyan , Zuo Yujing , Feng Shengyu , Liu Hongzhi
Published: October 2014

Luminescent porous polymers based on octavinylsilsequioxane and triphenylamine units show tunable porosity and luminescence, a moderate uptake of CO2 and high sensitivity for TNT.
Transparent conductive silver nanowire electrodes with high resistance to oxidation and thermal shock
Authors: Liu Bo-Tau , Huang Shao-Xian
Published: October 2014

Silver nanowire electrodes incorporated with polyethoxysiloxane reveal excellent resistance to oxidation and significantly increase conductivity by 1–2 orders of magnitude.
Alginic acid: a highly efficient renewable and heterogeneous biopolymeric catalyst for one-pot synthesis of the Hantzsch 1,4-dihydropyridines
Authors: Dekamin Mohammad G. , Ilkhanizadeh Siamand , Latifidoost Zahra , Daemi Hamed , Karimi Zahra , Barikani Mehdi
Published: October 2014

Alginic acid was found to be an efficient, environmentally benign, easily recoverable and low-cost catalyst for clean synthesis of 1,4-dihydropiridine derivatives (DHPs).