bluuebunny/crossref_metadata_2025 huggingface dataset:
Outcomes following Endoscopic-Assisted Woodward Procedure for Sprengel Deformity
Authors: Soldado Francisco , Barrera-Ochoa Sergi , Diaz-Gallardo Paula , Nguyen Trong-Quynh , Nguyen Dinh-Hung , Knörr Jorge
Published: November 2021

Purpose

An endoscopic-assisted approach for Sprengel deformity has been previously reported. Our objective was to assess outcomes of the endoscopic Woodward procedure in a series of patients.

Methods

Retrospective analysis was performed of children with a Sprengel deformity treated between November 2014 and February 2018. Recorded data were demographic, pre- and postoperative active shoulder elevation and deformity severity according to Cavendish.

Results

A total of 12 children (four girls and eight boys, ten right-sided/two left-sided) with a mean age of nine years two months (3 years 5 months to 16 years 1 month) and mean follow-up 19.8 months (10 to 48) were assessed. Nine children were classified as Cavendish Grade III and three as grade IV, respectively. Mean preoperative active shoulder forward elevation was 100.8° (70° to 120°), while postoperatively it increased to 149.2° (100° to 170°). Mean preoperative scapular high difference was 4.5 cm (2.8 to 5.2), while postoperatively it was 1.33 cm (0 to 2.8).

Conclusion

The endoscopic assisted Woodward procedure is an effective technique. Further comparative studies will ascertain advantages in functional and cosmetic results compared to the standard Woodward procedure.

Level of Evidence

Therapeutic study, Level IV
Type of non-reciprocity in a fiber Sagnac interferometer induced by geometric phases
Authors: Zhao Dongzi , Huang Jing-Zheng , Xiao Tailong , Li Hongjing , Wu Xiaoyan , Zeng Guihua
Published: November 2021

The non-reciprocity of a Sagnac interferometer provides ultra-high sensitivity for parameter estimation and offers a wide range of applications, especially for optical fiber sensing. In this work, we study a new type of non-reciprocity existing in an optical fiber Sagnac interferometer where the polarization dependent loss is taken into consideration. In particular, this non-reciprocity is irrelevant to the physical effects that have been considered in previous studies, which originates from the geometric phases induced by a continuous-weak-measurement. Thus, it has a unique phenomenon of sudden phase transition, which may open a new way for the future design of high precision optical fiber sensors.
Low-loss Ge waveguide at the 2-µm band on an n-type Ge-on-insulator wafer
Authors: Zhao Ziqiang , Lim Cheol-Min , Ho Chongpei , Sumita Kei , Miyatake Yuto , Toprasertpong Kasidit , Takagi Shinichi , Takenaka Mitsuru
Published: November 2021

Integrated mid-infrared (MIR) photonics has been widely investigated for the past decade, where germanium (Ge) is a promising optical material in this regime. In this work, we studied the origin of optical losses in Ge waveguides on a Ge-on-insulator (GeOI) wafer fabricated using Smart-cut. We observed that the high optical loss was mainly due to the holes in Ge films, which were generated by crystal defects formed by hydrogen ion implantation for Smart-cut. Furthermore, we found that the carrier concentration profile after the splitting process in remaining Ge films depends on the hydrogen ion implantation energy and initial background doping concentration of Ge wafers. A higher proton implantation energy can lead to deeper penetration of hydrogen ions into Ge films with less damage remaining near the implantation surface, resulting in the successful fabrication of an n-type GeOI wafer with a low carrier density. As a result, we experimentally demonstrated a low-loss Ge waveguide on an n-type GeOI wafer with a propagation loss as low as 2.3 ± 0.2 dB/cm. This work suggests an approach to tailor the carrier type in a Ge film formed using Smart-cut for large-scale MIR Ge photonic integrated circuits.
‘Unusual ingredients’: Developing a cross-domain model for multisensory artistic practice linking food and music
Authors: Thompson-Bell Jacob , Martin Adam , Hobkinson Caroline
Published: November 2021

This article explores linkages between sensory experiences of food and music in light of recent research from gastrophysics, 4E cognition (i.e. embodied, embedded, extended and enactive) and ecological perception theory. Drawing on these research disciplines, this article outlines a model for multisensory artistic practice, and a taxonomy of cross-domain creative strategies, based on the identification of sensory affordances between the domains of food and music. Food objects are shown to ‘afford’ cross-domain interrelationships with sound stimuli based on our capacity to sense their material characteristics, and to make sense of them through prior experience and contextual association. We propose that multisensory artistic works can themselves afford extended forms of sensory awareness by synthesizing and mediating stimuli across the selected domains, in order to form novel, or unexpected sensory linkages. These ideas are explored with reference to an ongoing artistic research project entitled ‘Unusual ingredients’, creating new music to complement and enhance the characteristics of selected food.
Breve historia de los inicios del cine gastronómico: 1973-2010
Authors: Cartay Rafael , Chaparro-Martínez Exio Isaac
Published: November 2021

En este artículo estudiamos el inicio del cine gastronómico como un género cinematográfico, considerando el período que va desde 1973, cuando apareció La Grande Bouffé (La Gran Comilona), el film considerado inaugural del género de cine gastronómico, hasta el año 2010 cuando, consolidado el género, se observó una gran rivalidad entre los productores y directores europeos y estadounidenses. Se efectuó una investigación documental para analizar las contribuciones que diversos investigadores han realizado sobre el tema. Esta revisión bibliográfica sintetiza los resultados de investigaciones y establece el estado del arte. En ese período (1973-2010) se produjo una fuerte competencia en la industria cinematográfica, que terminó con la imposición de la supremacía de la cinematografía estadounidense en la producción de películas del género. Se verificó la evolución del género, tanto en sus aspectos cuantitativos como cualitativos, al igual que los factores responsables que explican la hegemonía estadounidense.
Con dos que se quieran
Authors: Mendoza Ruiz Mirelna , García Torres Daniel Sebastián , Cardero González Yeni Elena , Díaz Suárez Rosandra
Published: November 2021

La formación médica amerita una educación que estimule el conocimiento científico, en la cual el cine y sus muchos materiales audiovisuales concebidos para la televisión se vinculan como un ente facilitador al docente para elevar la cultura del estudiante y con ello incidir en la pertinencia de su gestión como futuro profesional de la salud pública, comprometido con la ética de su praxis y en particular con las investigaciones que implican ensayos en humanos. En este sentido sobresalen programas como la entrevista al Dr. Jorge Berlanga Acosta, eminente investigador en el espacio televisivo «Con dos que se quieran», empleado mediante el debate con los estudiantes de Medicina.
Doctor Finlay
Authors: D'Ottavio Cattani Alberto Enrique
Published: November 2021

El presente trabajo completa uno previo dedicado a Archibald Joseph Cronin y significa un hondo reconocimiento a él y a muchas personas, libros y películas que me guiaron hacia esa aventura atrapante e inacabable que es la Medicina

En tal sentido, reseña un producto televisivo escocés basado en historias de ese médico-escritor sobre un médico ficticio en la aldea escocesa, imaginaria y lacustre, de Tannochbrae, tras la Segunda Guerra Mundial.

Esta serie, continuación de la exitosa serie de la BBC de 191 episodios Casebook del Dr. Finlay (1962-1971), comprende cuatro temporadas de veintisiete episodios dramáticos y conmovedores (seis episodios por año en 1993 y 1994, siete en 1995 y ocho en 1996).

Excediendo las diversas situaciones humanas entre los residentes de la casa Arden, aborda ineludibles aspectos políticos, sociales, sanitarios y cinematográficos, incluidos en la serie y derivados de ella.
Semi-Automated Roller Parameters Extraction from Terrestrial Lidar
Authors: Deshpande Sagar S. , Falk Mike , Plooster Nathan
Published: November 2021

Rollers are an integral part of a hot-rolling steel mill. They transport hot metal from one end of the mill to another. The quality of the steel highly depends on the surface quality of the rollers. This paper presents semi-automated methodologies to extract roller parameters from terrestrial
lidar points. The procedure was divided into two steps. First, the three-dimensional points were converted to a two-dimensional image to detect the extents of the rollers using fast Fourier transform image matching. Lidar points for every roller were iteratively fitted to a circle. The radius
and center of the fitted circle were considered as the average radius and average rotation axis of the roller, respectively. These parameters were also extracted manually and were compared to the measured parameters for accuracy analysis. The proposed methodology was able to extract roller
parameters at millimeter level. Erroneously identified rollers were identified by moving average filters. In the second step, roller parameters were determined using the filtered roller points. Two data sets were used to validate the proposed methodologies. In the first data set, 366 out of
372 rollers (97.3%) were identified and modeled. The second, smaller data set consisted of 18 rollers which were identified and modelled accurately.
Analisa Optimalisasi “Abandoned Well Production” Menggunakan “Downhole Heat Exchanger (DHE)” Sebagai Sumber Energi Baru di Lapangan Panas Bumi Dieng
Authors: Nurrochim Wahyu Festiawan , Harmoko Udi
Published: November 2021

Dari potensi lapangan panasbumi di area WKP Dieng yang baru bisa dimanfaatkan sebesar 10,3% dari total cadangannya atau sebesar 60 MW dari 580 MW potensi energi panasbumi di area tersebut. Sumur produksi di lapangan Dieng ada beberapa yang sudah tidak ekonomis untuk digunakan pada Pembangkit Listrik Tenaga Panasbumi (PLTP) konvensional. Salah satu sumur produksi yang sudah tidak bernilai ekonomis, sudah ditinggalkan (abandoned), (dari data aktual yang didapat sumur tersebut masih memiliki potensi energi yang dapat digunakan pada sistem Binary Plant dengan mengkombinasikan sistem Downhole Heat Exchanger (DHE). Dari beberapa penelitian mengenai DHE system lebih banyak digunakan sebagai pemanas dan masih sangat rendah untuk dimanfaatkan sebagai power generated. Penelitian ini bertujuan untuk memanfaatkan abandoned production well di area lapangan panasbumi Dieng dapat dioptimalisasi sebagai alternatif baru untuk menghasilkan energi listrik. Dari potensi yang dimiliki oleh salah satu sumur produksi tersebut memiliki temperature gradien sebesar 7°C/100 m pada kedalaman 3000 m. Dari potensi tersebut didapatkan hipotesa awal dengan membandingkan penelitian-penelitian terdahulu bahwa pemanfaatan sumur abandoned dapat menghasilkan ouput netto daya listrik sebesar kurang lebih 3 MW. Namun pada penilitian ini hanya sebatas melakukan perbandingan teknologi DHE system dengan menggunakan karakteristik kondisi sumur yang sama, sehingga selanjutnya perlu dilakukan analisa termodinamika, pemodelan sistem dan keekonomiannya terhadap kelayakan investasi sistem DHE-Binary Plant di lapangan panasbumi Dieng.
Effects of long-term anti-ischemic drug treatment on Na,K-ATPase isoforms in cardiomyopathic hamsters
Authors: Maixent Jean Michel , Pierre Sandrine V. , Sadrin Stéphane , Guieu Régis , Paganelli Franck
Published: November 2021

We investigated the effects of long-term anti-ischemic therapy with trimetazidine on Na,K-ATPase (NKA) activity and protein expression in cardiomyopathy. NKA isoforms in membrane fractions from cardiomyopathic hamsters of the BIO 14.6 strain were studied and compared with those from healthy Syrian golden hamsters (F1B). Trimetazidine was orally administered to a subset of cardiomyopathic hamsters in the early stage of active disease (30 days) until the congestive stage (350 days). In the congestive stage of cardiac failure, the cardiomyopathic hamsters displayed altered NKA activity (-55 % vs. F1B; p<0.01), which was related to a specific decrease in abundance of the membrane NKA ?1 isoform (-27 % vs. F1B). Trimetazidine partially prevented the cardiomyopathy-induced changes in NKA activity (+38 %) and ?1 membrane expression (+ 66 %) without inducing changes in the expression of the ?2 isoform or 1 isoform of NKA. Cardiac hypertrophy and remodeling were reduced after trimetazidine treatment. Additionally, the abundance of NKA ?1 in membranes was negatively correlated with the ventricular weight/body weight ratio (an index of cardiac hypertrophy) (r2 = 0.99; p<0.0015). These findings suggest that some of the cardioprotective effect of trimetazidine during long-term cardiomyopathy may be achieved via regulation of cardiac remodeling and selective modulation cardiac NKA isoforms.
The mechanism of miR-410-3p and miR-34c in nasopharyngeal carcinoma development and progression
Authors: Zhu Li , Ni Zhigang , Liang Kuai , Tang Yan , Zhao Min , Chen Chun , Yuan Xiaolin
Published: November 2021

To investigate the relationship between miR-410-3p, miR-34c and nasopharyngeal carcinoma development, we detected the expression of miR-410-3p and miR-34c in nasopharyngeal carcinoma tissues and evaluate its clinical value as a molecular marker for predicting the prognosis in patients with nasopharyngeal carcinoma through clinical case study. To identify the role and mechanism of miR-410-3p and miR-34c in nasopharyngeal carcinoma development and progression. The expression of miR-410-3p and miR-34cin 300 cases of nasopharyngeal carcinoma tissues and 30 cases of paired adjacent normal breast tissues was detected by RT-qPCR. The paired t-test was used to compare the differences of miR-410-3pand miR-34c levels between the nasopharyngeal carcinoma and normal groups. The Chi-square test was used to compare the differences between miR-410-3p and miR-34c expression and clinicopathological factors. The Kaplan-Meier survival curve was used to analyze the relationship between miR-410-3p and miR-34c expression and 5-year overall survival (OS). The Cox proportional hazards regression model was used to evaluate the prognostic value. The results were validated by TCGA database. The expression of miR-410-3p was down-regulated in nasopharyngeal carcinoma tissues compared with that of paired normal tissues (P<0.001). The patients with lower miR-410-3p expression have a higher ratio of positive lymph node status (P=0.039) and a poorer 5-year disease-free survival (P=0.001) and 5-year overall survival (P = 0.002). The expression of mi R-34c was down-regulated in nasopharyngeal carcinoma tissues compared with that of paired normal tissues (P<0.001). Up-regulation of the miR-34c inhibited the viability of paired normal tissues (P<0. 01), but there was no significant change in migration of the paired normal tissues. Downregulation of mi R-34c promoted the viability and migration of paired normal tissues (P<0. 05). The expression of miR-410-3p and miR-34c levels are predictors for the OS in patients with nasopharyngeal carcinoma. The expression of miR-410-3p and miR-34c are molecular markers of early nasopharyngeal carcinoma metastasis and an independent prognostic biomarker for patients with nasopharyngeal carcinoma.
Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: A large-scale genetic association study
Authors: Li Rongyao , Zhang Xinyue , Yin Wei , Wang Yuzhuo , Liu Ying
Published: November 2021

The objective of this experiment was to observe the allele frequency and genotype distribution of some 9p21 SNPs in the Anhui Han population, and to study its relationship with the susceptibility to ischemic stroke. For this purpose, a collection of 992 patients with ischemic stroke confirmed and hospitalized in our hospital from October 2017 to October 2020 were used as the IS case group, and 951 normal people who had a healthy physical examination in the physical examination center of our hospital during the same period were selected as the control group. After informed consent, cubital venous blood of all subjects was collected, and epidemiological data of the subjects were collected; the rs2383206, rs2383207, rs10757274, and rs1333049 on chromosome 9p21 as the sites to be tested, using Sequenom Mass Array system for genotyping, using Haploview4.2 software to calculate whether the genotype distribution meets Hardy-Weinberg equilibrium. Results showed that there were no significant differences between the two groups in gender, age, and smoking history. There are significant differences in the levels of hypertension, diabetes and hyperlipidemia, total cholesterol, triglycerides, HDL-C and apolipoprotein A1 between the two groups of study subjects. The genotype frequencies of the participating populations were in a balanced state. The results of the association analysis between SNPs and IS susceptibility showed that rs2383207, rs10757274, rs1333049 and rs2383206 are the susceptibility sites of ischemic stroke. It concluded that in Anhui, China, the inheritance of chromosome 9p21 region is associated with ischemic stroke.
Isolation and production of organic solvent tolerant protease from bacterial burn infection, Staphylococcus aureus KP091274
Authors: Liao Xin , Teng Liqun , Li Wei
Published: November 2021

Organic solvent-resistant proteases are used to synthesize valuable pharmaceutical and industrial compounds. Using an available and inexpensive source can be very effective in producing this enzyme. For this purpose, Staphylococcus aureus KP091274 was isolated from burn infection and a medium optimization procedure in the presence of organic solvents was considered for four factors of incubation time, the concentration of Mg2+, glycerol and sorbitol using the response surface methodology. The results of this statistical method showed that incubation time has the most effect and glycerol concentration has the least positive effect on enzyme secretion. As a result of applying the optimized conditions in the bacterial culture medium (3mM of Mg2+, 1.5% W/V of glycerol, 0.4% W/V of sorbitol and 72 hours of incubation), the enzyme secretion reaches its maximum.
Antimetastatic effects of Citrus-derived bioactive ingredients: Mechanistic insights
Authors: Farooqi Ammad Ahmad , Tahir Fatima , Fakhar Maham , Butt Ghazala , Colombo Pimentel Tatiana , Wu Ning , Yulaevna Ishmuratova Margarita , Attar Rukset
Published: November 2021

The growing complexity of metastasis has sparked tremendous interest in unraveling of the underlying mechanisms which play fundamental role in cancer progression and metastasis. Ground-breaking discoveries in metastasis research have greatly enhanced our understanding about intricate nature of metastasis. Bioactive chemicals obtained from citrus fruits have gained noteworthy appreciation because of significant cancer chemopreventive roles. Deregulated oncogenic signaling cascades play central role in metastasis. Emerging evidence has started to shed light on the metastasis inhibitory properties of naringin, naringenin, tangeretin, nobiletin, hesperidin and hesperetin in different cancer cell lines and xenografted mice. Wnt/β-catenin, TGF/SMAD and NOTCH signaling cascades have been shown to play linchpin role in carcinogenesis and metastasis. There is emerging evidence related to pharmacological targeting of Wnt/β-catenin, TGF/SMAD and NOTCH by citrus-derived bioactive components. These findings are indeed encouraging and will enable researchers to gain further insights into pharmacological targeting of oncogenic pathways to inhibit and prevent metastasis.
Estimation of vitamin D receptor gene polymorphism in Type 2 Diabetes Mellitus patients in Erbil city
Authors: Maulood Kalthum Asaaf
Published: November 2021

Type 2 diabetes mellitus (T2DM) is a global problem. Recent studies confirmed the association of genes and different single nucleotide polymorphisms with T2DM occurrence and progress. This study was aimed to estimate the vitamin D receptor (VDR) gene polymorphism in Type 2 Diabetes Mellitus patients in Erbil city. The results showed that the Body mass index (BMI), Systolic blood pressure and Diastolic blood pressure were significantly higher in the diabetic group compared to the control group (P<0.05). In addition, the percent of Glycated hemoglobin (HbA1c), Fasting blood glucose (FBG), and Homeostatic model assessment for insulin resistance (HOMA-IR) were significantly higher in the diabetic group compared to the control group (P<0.05). Among different parameters of lipid profile, only Low-density lipoprotein (LDL) was significantly higher in the diabetic group compared to the control group. It was found that FBG value was significantly higher in patients with GA and AA genotypes of BsmI compared with healthy controls. Patients with the GA genotype of BsmI had a higher value of triglyceride compared to healthy individuals. Patients with all ApaI genotypes had higher FBS values than controls. There were not observed any signi?cant associations among the BsmI and ApaI polymorphisms and the risk of T2DM. In conclusion, no evidence was found for the association between two VDR polymorphisms and T2DM patients in Erbil city.
Preoperative thyroid-stimulating hormone associated risk of differentiated thyroid cancer in patients with thyroid nodules
Authors: M Al Essa
Published: November 2021

In an assessment of risk for differentiated thyroid cancer (DTC) in individuals with human papillary thyroid cancer (PTC) and thyroid nodules a cohort prospective study was undertaken to establish the significance of preoperative thyroid-stimulating hormone (TSH) levels. Confirmed histologically PTC cases in one tertiary care center, and matched healthy individuals were tested for TSH, T3, T4 and T4 free total. The ORs and 95% confidence intervals have been calculated using conditional logistic regression models (CI). The blood TSH levels were related to the higher risk of PTC for men (OR,0,09; 95% Ci, 04–0,21, 95% CI and women) compared with the middle tertile of the TSH levels in the normal range (OR,0,07; 95 percent CI, 0,04–0,1). Over the normal range of TSH levels, an elevated PTC risks were connected amongst women (OR 0,09; 95% CI, 0,04–0,21) but not amongst men (OR,0,07; 95% CI, 0,04–0,1). With an increase in TSH level in the normal range between men and women, the risk for PTC reduced (Ptrend=0.041 and 0.0001). The risk of PTC related to TSH levels has been dramatically elevated above  the normal range for men  and TSH values below the normal range for women.
Serum JAK/STAT profile is related to the IL expression but not with the outcome in pancreatic adenocarcinoma patients
Authors: Petrusel Livia , Ilies Maria , Leucuta Daniel , Rusu Ioana , Seicean Andrada , Iuga Cristina , Seicean Radu
Published: November 2021

Current genetic characterization of pancreatic ductal adenocarcinoma (PDAC) does not integrate the host reaction to cancer cells and cannot predict the response to chemo- or immunotherapy. The JAK/STAT pathway is an important factor of cytokine-mediated cancer inflammation, but its relationship with pancreatic carcinogenesis and the role of potential biomarkers is not established yet. Our study aimed to assess the significance of serum levels of JAK/STAT3 expression and inflammatory cytokines in PDAC in relation to the clinicopathological features and prognosis. This prospective cohort study included patients with proven adenocarcinoma and a matched group of controls without any malignancies. There were evaluated the serum expression of IL2, 6, 8, 17, JAK2, and STAT3 by ELISA assays in these two groups. The PDAC patients were followed up for 24 months. A Cox regression multivariate analysis model was used to determine factors influencing survival. The study comprised 56 patients with PDAC and 56 controls. The upregulated serum JAK2/STAT3 or cytokines were present in about half of the patients with PDAC, similar to controls. The expression of JAK2 in serum of PDAC patients was significantly associated with the expression of IL2 (p=0.03) and IL6 (p=0.02) but not with survival or metastasis development. Only age and the presence of lymph node metastases were associated with reduced survival in multivariate analyses. The STAT 3/JAK2 expression, although correlated with inflammatory status (IL2, IL6) was not overexpressed in PDAC compared to controls and proved no prognostic value.
The effect of Chaihu-shugan-san on cytotoxicity induction and PDGF gene expression in cervical cancer cell line HeLa in the presence of paclitaxel +cisplatin
Authors: Jianfang Xue , Ling Zhu , Yanan Jiao , Yanliang Guan
Published: November 2021

Chaihu-shugan-san, as a traditional Chinese herbal formula, is composed of seven different herbs. This medicine can treat cancer due to its antioxidant compounds. In this study, the effect of Chaihu-shugan-san was considered on cytotoxicity induction and PDGF gene expression in cervical cancer cell line HeLa at different concentrations and at different times, by the MTT method. Paclitaxel + cisplatin were used as a control in this study. The expression of the PDGF gene was quantitatively evaluated in treated cells by real-time PCR, and a generalized linear model was used to evaluate the effect of the medicine, and Duncan's multiple range tests were used to evaluate the data. The results of the MTT test showed that Chaihu-shugan-san had antitumor properties in different concentrations, but there was a significant difference between this medicine and paclitaxel +cisplatin. Also, examination of gene expression showed that this medicine reduced the expression of the PDGF gene in the HeLa cancer cell line (P ? 0.04). Therefore, Chaihu-shugan-san could be suggested as an effective factor in preventing the growth of cervical cancer cells and controlling angiogenic factors that play an important role in the metastasis of cancerous tumors.
The clinical effects of resveratrol on atherosclerosis treatment and its effect on the expression of NADPH oxidase complex genes in vascular smooth muscle cell line
Authors: Lixia Guo , Haiyun Zhao , Xia Zheng
Published: November 2021

Atherosclerosis is a disease that covers the arteries of the middle to large arteries and can affect the aorta to the coronary arteries. Atherosclerosis is a progressive and slow process that begins in childhood and leads to clinical manifestations in adulthood. Increased activity of the NADPH oxidase complex plays an important role in the development of this complication. In this study, the clinical effects of resveratrol were considered on atherosclerosis treatment and its effect on the expression of NADPH oxidase complex genes was performed in the vascular smooth muscle cell line. For this purpose, 120 Chinese Patients prone to atherosclerosis participated for 12 months. These patients were divided into two groups of 60 patients. The first group was treated to the placebo and the second group was treated to 100 mg/day resveratrol for 12 months. Also, the expression of gp91Phox and P22Phox subunits of NADPH oxidase complex was evaluated in vascular smooth muscle cells by real-time PCR technique. The results showed that resveratrol could decrease systolic blood pressure, diastolic blood pressure, cholesterol, triglyceride, and low-density lipoprotein (LDL). It was also able to reduce the expression of gp91Phox and P22Phox subunits of NADPH oxidase complex in the vascular smooth muscle cell line. Therefore, it is possible to introduce resveratrol as an able medicine to treat atherosclerosis. However, more studies are needed to complete the information about the role of resveratrol.
The effect of transcutaneous electrical nerve stimulation (TENS) on pain control and phenylethanolamine-N-methyltransferase (PNMT) gene expression after cesarean section
Authors: Chen Wenxiang , Liu Chunying , Yang Yongrong , Tian Lili
Published: November 2021

Transcutaneous electrical nerve stimulation (TENS) is one of the non-pharmacological methods of pain relief that has been able to reduce pain by 70 to 90% in postoperative pain control. This study aimed to determine the effect of TENS on pain control after cesarean section and its effect on PNMT gene expression. For this purpose, a double-blind randomized clinical trial was performed on 70 Chinese patients with elective cesarean section. Patients were divided into case and control groups. In the case group, TENS and analgesic drugs were used to relieve pain, and in the control group, the only analgesic drug was used. Then the severity of pain, recurrence of pain attacks, the number of analgesic drugs used and the amount of analgesic drug used in the first 24 hours after surgery were evaluated and compared. Blood samples were also taken from patients to evaluate PNMT gene expression. The semi-quantitative RT-PCR was used to study changes in gene expression. The results showed that the group treated with TENS had less pain intensity and less recurrence of pain attacks than the group that received only analgesic medication. Also, the frequency of analgesic drug use and its dose in the TENS group were significantly lower than in the control group. TENS, on the other hand, has been able to greatly reduce the expression of the PNMT gene, which is produced during times of stress. Therefore, it is recommended that TENS be used as a non-invasive and non-pharmacological adjuvant effective in reducing pain after cesarean section.
Evaluation of blaGES-5 and bla veb-1 genes with multidrug-resistant extend, pandrug resistance patterns (MDR, XDR, PDR), and biofilm formation in Pseudomonas aeruginosa isolates
Authors: Ali Fattma A. , Bakir Sevan Hassan , Haji Sayran Hamed , Hussen Bashdar M.
Published: November 2021

Pseudomonas aeruginosa is a ubiquitous microorganism that is difficult to treat due to the increasing prevalence of multidrug resistance patterns. A total of 227 samples were taken from different clinical samples during the study period from January 2018 to December 2018. The isolates were identified with antibiotic sensitivity testing with ESBL by the Vitek-2 automated method. MDR, XDR, and PDR were determined. 40 (17.6%) isolates were positive for P. aeruginosa, maximum of ESBL and MBL. Positive isolates were detected in the burn, coexisting ESBL + MBL enzymes in 21 (52.5%) of our isolates. Imipenem followed by Meropenem were found to be effective against ESBL and MBL producers. Resistance was reached between 72-100% to 5 antibiotics. The frequency of PDR, MDR, and XDR were 5%, 50%, and 45%, respectively. The frequency of co-production between MDR, XDR, and PDR with MBL, ESBL, and Biofilm was 35%, 12.5% and 5%, respectively. Among the ESBLs, the frequency of distribution of bla VEB-1gene and blaGES-5 gene was 50% and 40 %, respectively. Bacterial isolates simultaneously carrying blaVEB-1 gene with multiple ?-lactamases of different classes of biofilm, MDR, PDR, and XDR as same as a coexisting blaGES-5 gene. One isolate was detected as new isolates registered in global gene bank as locally P. aeruginosa isolates in Erbil city (LOCUS MN900953). The phylogenetic trees of the blaVEB gene isolates were demonstrated a genotype closely related to others, deposited in GenBank similar to the P. aeruginosa gene; gene sequencing revealed a 99% similarity with other isolates deposited in GenBank.
Prognostic value of absolute lymphocyte/monocyte ratio, red cell distribution width and neutrophil/ lymphocyte ratio in diffuse large B-cell lymphoma patients
Authors: Hasan Kawa Muhamedamin , Elmeshhedany Ahmed Yassin
Published: November 2021

Diffuse large B-cell lymphoma (DLBCL) is an aggressive and rapid-growing form of non-Hodgkin lymphoma (NHL). The objective of this research was to assess the predictive role of lymphocyte to monocyte ratio (LMR), red cell distribution width (RDW) and neutrophil to lymphocyte ratio (NLR) values in the survival of DLBCL patients. A retrospective analysis of 136 DLBCL patients admitted to Nanakali Hospital for blood diseases and oncology from 2010-2020 was done. We assessed the correlation of LMR, RDW and NLR with patients’ characteristics and the impact on survival by the Kaplan–Meier method, the log-rank test, and Cox regression models for multivariate analysis. The complete remission rate was 61.7%, with a 5- year overall survival (OS) and progression-free survival (PFS) of 59.5% and 60%, respectively. The Log-rank test showed that LMR was significantly correlated with Ann Arbor staging (p= 0.040). There is a significant association between RDW and Eastern Cooperative Oncology Group performance status (ECOG-performance status) (p= 0.022), B symptoms (p= 0.026), Revised International prognostic index (R-IPI) (p= 0.004), lactate dehydrogenase (LDH) (p= 0.021), and beta 2 microglobulin (B2MG) (p= 0.007), whereas NLR had a significant correlation with LDH only (p=0.016). There were no significant differences in the 5-year OS or PFS in patients with different levels of RDW, LMR, and NLR. LMR, RDW and NLR were correlated with many of patients’ characteristics. However, none of the LMR, RDW and NLR did possess value to predict OS and PFS, and they cannot be used as biomarkers for survival evaluation of DLBCL.
The effect of cellular and physiological indicators on gender determination
Authors: Haje Milat Ismail
Published: November 2021

Gender determination, in addition to having special value to parents, has particular importance in sex-linked diseases. This study aimed to investigate the cellular indicators (i.e. BMP-6 protein and PPAR? protein expression levels in granulosa cells) and the physiological indicators on gender determination. For this purpose, on 68 infertile patients referred to the clinic, ovarian stimulation was performed by different protocols and then ruptured by different HCG. Follow-up of patients was performed after they became pregnant after five months. U/S was done for knowing the gender of the baby then after labor rechecked another time. Also, granulosa-luteal cells (GLCs) were isolated from the follicular fluid of 68 women participating in the study. BMP-6 protein and PPAR? protein were measured using Western blotting. Results showed that the total number of delivered babies was 68, 41 males (60.3%) and 27 females (39.7%). About physiological indicators results, there was no significant association between the age of the mother and sex of the baby (P=0.934). No significant association was detected between the month during which the conception occurred and the sex of the baby (P=0.734). The same result was obtained for the follicle side (P=0.236), and follicle size (P=0.659), there was no significant association between the sex of the baby with the following factors: protocol of treatment (P=0.417), IVF after HCG (P=0.237), HCG type (P=0.572), parity (P=0.282), and type of infertility (P=0.376). The cellular indicators results showed that the BMP-6 protein level in granulosa cells of mothers with daughters was almost twice as high as mothers with sons (P=0.043). But there was no significant difference between mothers with daughters and mothers with sons in PPAR? protein level (P=0.12). It can be concluded that except for BMP-6 protein level, none of the cellular and physiological indicators affects gender determination. Therefore, this cell indicator can probably be evaluated as an effective indicator in determining gender.
Pobożność maryjna w kontekście pism Johna Henry’ego Newmana
Authors: Majewska-Michy Justyna
Published: November 2021

The article seeks to answer whether John Henry Newman (1801-1890), outstanding theologian of nineteenth-century England and  a Catholic convert, was particularly worshipful of Holy Virgin Mary. He would express his piety towards the Blessed Virgin, revered as the Mother of God, through his writings. The author thus analyzes the publications from the Anglican and the Catholic periods in Newman’s life, in which the latter referred to the Mother of the Word Incarnate. In his sermons, essays, speeches, lectures and letters, the eminent representative of the English Church conveys his attitude to the Mother of God.
The linguistic picture of St. Mary in John Henry Newman’s „Parochial and Plain Sermons”
Authors: Kuczok Marcin
Published: November 2021

The aim of the paper is to analyze the linguistic picture of St Mary in John Henry Newman’s „Parochial and Plain Sermons” (1834-1843), published in the Anglican period of his life. The study focuses on identifying such elements of the linguistic picture of St. Mary as her titles and names, events from her life, various roles, attributes, and traits of personality depicted in Newman’s sermons.
Zarys dziejów baliwatu brandenburskiego joannitów do końca XVI w. Wpływ reformacji na jego funkcjonowanie
Authors: Wasilkiewicz Kamil
Published: November 2021

The article discusses selected fragments of history of the Bailiwick of Brandenburg, a jurisdiction of the Knights Hospitaller until the end of the 16th century, showing structural transformations it underwent over the centuries. Having outlined the social and political foundation of its functioning, the author presents the influence that the Reformation had on the bailiwick.
O anglikańskiej mariologii w kontekście pism J. H. Newmana
Authors: Majewska-Michy Justyna
Published: November 2021

O anglikańskiej mariologii w kontekście pism J. H. Newmana
Rescuing the Muslim collective self: the Nur case in light of the Modern Muslim Subjectivities Project
Authors: Vicini Fabio
Published: November 2021

There is a tendency in the literature to emphasise how contemporary Islamic movements promote ways of living a pious Muslim life alternative to those proposed by secular liberal modernity. For this reason, the domains of religious and civic engagement have often been thought of as opposed to each other. In counterpoint to this tendency, the paper explores the intertwining of national views about mass education and modern citizenship with a renewed Islamic emphasis on the need for moral and ethical reform of society within the Nur movement in modern Turkey. Methodologically, the paper draws upon ethnographic material from research conducted in 2010 on the Suffa community in Istanbul, as well as on an account of the life and projects of the leader of the movement, Said Nursi, mainly drawn from secondary sources. This case is explored in light of the theories of successive modernities that inspired the analytical framework for the Modern Muslim Subjectivities Project applied in this special issue. In so doing, it illustrates the complex nexus that Nursi established between long-standing views of Islamic ethics and modern perspectives on education and civic engagement in response to the emergence of the modern nation-state in the first half of the 20th century.
Comparison of modified ADM and classical finite difference method for some third-order and fifth-order KdV equations
Authors: Appadu Appanah Rao , Kelil Abey Sherif
Published: November 2021

The KdV equation, which appears as an asymptotic model in physical systems ranging from water waves to plasma physics, has been studied. In this paper, we are concerned with dispersive nonlinear KdV equations by using two reliable methods: Shehu Adomian decomposition method (STADM) and the classical finite difference method for solving three numerical experiments. STADM is constructed by combining Shehu’s transform and Adomian decomposition method, and the nonlinear terms can be easily handled using Adomian’s polynomials. The Shehu transform is used to accelerate the convergence of the solution series in most cases and to overcome the deficiency that is mainly caused by unsatisfied conditions in other analytical techniques. We compare the approximate and numerical results with the exact solution for the two numerical experiments. The third numerical experiment does not have an exact solution and we compare profiles from the two methods vs the space domain at some values of time. This study provides us with information about which of the two methods are effective based on the numerical experiment chosen. Knowledge acquired will enable us to construct methods for other related partial differential equations such as stochastic Korteweg-de Vries (KdV), KdV-Burgers, and fractional KdV equations.
The Curvilinear Relationship Between Collective Team Identification and New Venture Performance: The Moderating Effect of Environmental Uncertainty
Authors: Ji Hao , Zhou Wencang
Published: November 2021

Many new ventures are founded and developed by teams rather than solo entrepreneurs. Therefore, the extent to which entrepreneurs identify with their teams is likely to have an important impact on the process and outcome of new venture creation in new venture teams. However, most of the relevant studies focus on entrepreneurs’ individual identity, and the identity at the team level has been overlooked. This study seeks to fill this gap by exploring the effect of collective team identification on new venture performance. The relationship between collective team identification and new venture performance was examined using a sample of 54 new venture teams in Internet Technology (IT) industry. The results show that the relationship between collective team identification and new venture performance is inverted U-shaped. Moreover, environmental uncertainty may moderate this curvilinear effect, such that this inverted U-shaped relationship is more salient at a low level of environmental uncertainty rather than at a high level of environmental uncertainty.
The impact of pragmalinguistic support on video-conferenced collaborative suggestion-giving task
Authors: Jung Jookyoung , Fu Xuehua
Published: November 2021

This study explored the impact of pragmalinguistic support on L2 users’ suggestion-giving task performance. Data came from 12 pairs of L2 users in a Zoom-mediated university course. They collaboratively wrote suggestions for improvement in their peers’ lesson plans using Office 365. Six pairs received pragmalinguistic support, while the others wrote their suggestions on their own. Audio-recorded pair discussions were coded qualitatively, and the written suggestions were analyzed in terms of linguistic and pragmatic characteristics. The results showed that pragmalinguistic support encouraged the participants to engage more in language-related and task-related episodes. Also, their suggestions contained more diverse lexical downgraders and conventional suggestion-giving expressions. By contrast, those who wrote suggestions without pragmalinguistic support engaged more in pragmatic-related episodes, relying extensively on epistemic modal verbs (e.g., would). The findings indicate that pragmalinguistic support may help L2 users to better attend to task content and language, producing lexically and pragmatically richer output.
Stress, gender, and declension class in Belarusian
Authors: Bethin Christina Y.
Published: November 2021

Ongoing innovations in Standard Belarusian nominal declension indicate that speakers are aware of and actively using paradigmatic stress patterns for grammatical purposes. The adoption of new mobile stress patterns in paradigms which originally had fixed stress is now complementary in Declension Ia masculine nouns and in Declension II feminine nouns; most neuter nouns simply default to fixed stem stress. The highlighting of grammatical gender distinctions via changes in paradigmatic stress patterns has led to a reanalysis of stress, gender, and declension class in common gender and a-stem masculine nouns and their case exponents have now become stress-dependent, a situation markedly distinct from that found in the other closely related East Slavic languages, Russian, and Ukrainian. These developments pose a challenge for several theories of morphology, either because the theory takes paradigmatic stress to be dependent on declension class or because the theory does not have a provision for paradigmatic stress to determine inflectional exponents.
Furanone-functionalized benzothiazole derivatives: synthesis, in vitro cytotoxicity, ADME, and molecular docking studies
Authors: Husain Asif , Bedi Silky , Parveen Shazia , Khan Shah Alam , Ahmad Aftab , Iqbal Md Azhar , Farooq Aasif , Ahmed Anwar
Published: November 2021

In the present study, a novel series of new furanone-based benzothiazole derivatives (4a-j) were synthesized from 4-(benzo[d]thiazol-2-yl)-4-oxobutanoic acid (3) as potential anticancer agents. In vitro cytotoxicity against three human cancer cell lines (A549, MCF7, and DUI45) revealed substantial activity. Di-substituted compound, 4i emerged as a promising anticancer compound which showed IC50 values of 7.2 ± 0.5, 6.6 ± 1.4, and 7.3 ± 0.1 µM against A549, MCF7, and DUI45 cell lines, respectively. Four compounds 4c, 4e, 4f, and 4i evaluated for their acute toxicity were found to be non-toxic on the two vital organs (liver and heart). Further, these compounds were found to be more efficient and less hepatotoxic in comparison to standard drug doxorubicin. Molecular docking studies carried out with VEGFR-2 revealed compounds 4a and 4i as potential VEGFR-2 kinase inhibitors. In silico ADME evaluation was carried out to estimate and predict drug-likeness. Compound 4i demonstrated the best ADME parameters. Based on the results of docking analyses, ADME, and in vitro cytotoxicity, compound 4i is identified as the lead compound for further development of anticancer agents.
EARLY DIAGNOSTICS OF ISCHEMIC DAMAGES OF THE MYOCARDIUM BY MEANS OF THE MARKER OF OPENING THE MITOCHONDRIAL PORE
Authors:   O.O. Bogomoletz Institute of Physiology National Academy Sciences of Ukraine, Kyiv, Ukraine, Sagach V. F. , Dmitrieva A.V. ,   O.O. Bogomoletz Institute of Physiology National Academy Sciences of Ukraine, Kyiv, Ukraine, Bubnova J.A. ,   O.O. Bogomoletz Institute of Physiology National Academy Sciences of Ukraine, Kyiv, Ukraine, Maksimenko V. B. ,   M.M. Amosov Institute Surgery Academy Medical Sciencesof Ukraine, Kyiv, Ukraine, Knyshov G.V. ,   M.M. Amosov Institute Surgery Academy Medical Sciencesof Ukraine, Kyiv, Ukraine
Published: November 2021

In the article a possibility of definition of level of the mitochon-drial factor (MF) for early diagnostics of the myocardial is chemic damages at patients during heart surgery was investigated. The reperfusion damages of heart were manifested by MPTP activation and MF release. The rising of MF level during a cardioplegia is comparable to level, which has been noted at patients with angina before operation of aorto-coronary shunting. The beginning of reperfusion, practically did not change MF level, but 5 minutes after restoration of a blood flow and warm reductions it increased to the maximum values. Thus, it closely correlated with a level of a myocardial contractility de­pression and data of biochemical researches, which are tradi­tionally used in clinic for diagnostics of damages of a heart. It allows to confirm, what exactly reperfusion is a major factor damaging of a myocardium. Its important that, change of MF level we registered at first minutes of heart reperfusion, those are much earlier, than by means of other markers. It seems to us, that investigation of a MF is very perspective for early find­ing of an ischemic damages of different tissues and organs.