bluuebunny/crossref_metadata_2025 huggingface dataset:
Beneficial Effects of Rosmarinic Acid on IPEC-J2 Cells Exposed to the Combination of Deoxynivalenol and T-2 Toxin
Authors: Pomothy Judit Mercédesz , Barna Réka Fanni , Pászti Erzsébet Anna , Babiczky Ákos , Szóládi Áron , Jerzsele Ákos , Gere Erzsébet Pásztiné
Published: December 2020

Mycotoxin contamination in feedstuffs is a worldwide problem that causes serious health issues both in humans and animals, and it contributes to serious economic losses. Deoxynivalenol (DON) and T-2 toxin (T-2) are major trichothecene mycotoxins and are known to challenge mainly intestinal barrier functions. Polyphenolic rosmarinic acid (RA) appeared to have antioxidant and anti-inflammatory properties in vitro. The aim of this study was to investigate protective effects of RA against DON and T-2 or combined mycotoxin-induced intestinal damage in nontumorigenic porcine cell line, IPEC-J2. It was ascertained that simultaneous treatment of DON and T-2 (DT2:

1
 
μ
mol
/
L
 
DON
+
5
 
nmol
/
L
 
T
−
2

) for 48 h and 72 h reduced transepithelial electrical resistance of cell monolayer, which was restored by 50 μmol/L RA application. It was also found that DT2 for 48 h and 72 h could induce oxidative stress and elevate interleukin-6 (IL-6) and interleukin-8 (IL-8) levels significantly, which were alleviated by the administration of RA. DT2 administration contributed to the redistribution of claudin-1; however, occludin membranous localization was not altered by combined mycotoxin treatment. In conclusion, beneficial effect of RA was exerted on DT2-deteriorated cell monolayer integrity and on the perturbated redox status of IPEC-J2 cells.
A Redescription of the Bulla, Antennae, and Mouth Parts of Female Clavella sp. (Copepoda: Siphonostomatoida: Lernaeopodidae) Infesting Wild Gadus morhua Using Scanning Electron Microscopy (SEM)
Authors: Murray Harry M. , Hanlon Jacqueline M. , Marshall Kimberly , Morris Corey
Published: December 2020

Many members of the Copepod family Lernaeopodidae are well-known parasites of gadids. This study reports on the occurrence of a lernaeopodid infestation of wild-sourced Gadus morhua sampled from separate inshore (Gilbert Bay, NL) and offshore (Virgin Rocks, NL) populations from Newfoundland, Canada. The majority of the parasites were observed to be associated with the buccal cavity, gill filaments, gill arch, and occasionally near the outer edge of the operculum. Anatomical analysis and detailed redescriptions of the parasite’s functional anatomy (mouth parts, antennae, and bulla complex) using high-resolution SEM indicated that the parasite was most likely of the genus Clavella. New morphological details of the second antennae ornamentation, first maxillae, bulla complex, and the oral cone are provided and discussed with regard to their potential in taxonomic applications.
Pharmacologic Activation of LXR Alters the Expression Profile of Tumor-Associated Macrophages and the Abundance of Regulatory T Cells in the Tumor Microenvironment
Authors: Carbó José M. , León Theresa E. , Font-Díaz Joan , De la Rosa Juan Vladimir , Castrillo Antonio , Picard Felix R. , Staudenraus Daniel , Huber Magdalena , Cedó Lídia , Escolà-Gil Joan Carles , Campos Lucía , Bakiri Latifa , Wagner Erwin F. , Caelles Carme , Stratmann Thomas , Van Ginderachter Jo A. , Valledor Annabel F.
Published: December 2020

Liver X receptors (LXR) are transcription factors from the nuclear receptor family that are activated by oxysterols and synthetic high-affinity agonists. In this study, we assessed the antitumor effects of synthetic LXR agonist TO901317 in a murine model of syngeneic Lewis Lung carcinoma. Treatment with TO901317 inhibited tumor growth in wild-type, but not in LXR-deficient mice, indicating that the antitumor effects of the agonist depends on functional LXR activity in host cells. Pharmacologic activation of the LXR pathway reduced the intratumoral abundance of regulatory T cells (Treg) and the expression of the Treg-attracting chemokine Ccl17 by MHCIIhigh tumor-associated macrophages (TAM). Moreover, gene expression profiling indicated a broad negative impact of the LXR agonist on other mechanisms used by TAM for the maintenance of an immunosuppressive environment. In studies exploring the macrophage response to GM-CSF or IL4, activated LXR repressed IRF4 expression, resulting in subsequent downregulation of IRF4-dependent genes including Ccl17. Taken together, this work reveals the combined actions of the LXR pathway in the control of TAM responses that contribute to the antitumoral effects of pharmacologic LXR activation. Moreover, these data provide new insights for the development of novel therapeutic options for the treatment of cancer.

Significance:

This study reveals unrecognized roles of LXR in the transcriptional control of the tumor microenvironment and suggests use of a synthetic LXR agonist as a novel therapeutic strategy to stimulate antitumor activity.
The Glutaminase Inhibitor CB-839 (Telaglenastat) Enhances the Antimelanoma Activity of T-Cell–Mediated Immunotherapies
Authors: Varghese Sruthy , Pramanik Snigdha , Williams Leila J. , Hodges Hannah R. , Hudgens Courtney W. , Fischer Grant M. , Luo Catherine K. , Knighton Barbara , Tan Lin , Lorenzi Philip L. , Mackinnon Andrew L. , McQuade Jennifer L. , Hailemichael Yared , Roszik Jason , Peng Weiyi , Vashisht Gopal Y.N.
Published: December 2020

Immune-checkpoint inhibitors and adoptive tumor-infiltrating lymphocyte (TIL) therapies have profoundly improved the survival of patients with melanoma. However, a majority of patients do not respond to these agents, and many responders experience disease relapse. Although numerous innovative treatments are being explored to offset the limitations of these agents, novel therapeutic combinations with immunotherapies have the potential to improve patient responses. In this study, we evaluated the antimelanoma activity of immunotherapy combinations with Telaglenastat (CB-839), a potent glutaminase inhibitor (GLSi) that has favorable systemic tolerance. In in vitro TIL:tumor coculture studies, CB-839 treatment improved the cytotoxic activity of autologous TILs on patient-derived melanoma cells. CB-839 treatment decreased the conversion of glutamine to alpha-ketoglutarate (αKGA) more potently in tumor cells versus TILs in these cocultures. These results suggest that CB-839 may improve immune function in a tumor microenvironment by differentially altering tumor and immune cell metabolism. In vivo CB-839 treatment activated melanoma antigen–specific T cells and improved their tumor killing activity in an immune-competent mouse model of adoptive T-cell therapy. Additionally, the combination of CB-839 with anti-PD1 or anti-CTLA4 antibodies increased tumor infiltration by effector T cells and improved the antitumor activity of these checkpoint inhibitors in a high mutation burden mouse melanoma model. Responsiveness to these treatments was also accompanied by an increase of interferon gamma (IFNγ)–associated gene expression in the tumors. Together, these results provide a strong rationale for combining CB-839 with immune therapies to improve efficacy of these treatments against melanoma.
Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12
Authors: Lewis Nuruddeen D. , Sia Chang Ling , Kirwin Katherine , Haupt Sonya , Mahimkar Gauri , Zi Tong , Xu Ke , Dooley Kevin , Jang Su Chul , Choi Bryan , Boutin Adam , Grube Andrew , McCoy Christine , Sanchez-Salazar Jorge , Doherty Michael , Gaidukov Leonid , Estes Scott , Economides Kyriakos D. , Williams Douglas E. , Sathyanarayanan Sriram
Published: December 2020

The promise of IL12 as a cancer treatment has yet to be fulfilled with multiple tested approaches being limited by unwanted systemic exposure and unpredictable pharmacology. To address these limitations, we generated exoIL12, a novel, engineered exosome therapeutic that displays functional IL12 on the surface of an exosome. IL12 exosomal surface expression was achieved via fusion to the abundant exosomal surface protein PTGFRN resulting in equivalent potency in vitro to recombinant IL12 (rIL12) as demonstrated by IFNγ production. Following intratumoral injection, exoIL12 exhibited prolonged tumor retention and greater antitumor activity than rIL12. Moreover, exoIL12 was significantly more potent than rIL12 in tumor growth inhibition. In the MC38 model, complete responses were observed in 63% of mice treated with exoIL12; in contrast, rIL12 resulted in 0% complete responses at an equivalent IL12 dose. This correlated with dose-dependent increases in tumor antigen–specific CD8+ T cells. Rechallenge studies of exoIL12 complete responder mice showed no tumor regrowth, and depletion of CD8+ T cells completely abrogated antitumor activity of exoIL12. Following intratumoral administration, exoIL12 exhibited 10-fold higher intratumoral exposure than rIL12 and prolonged IFNγ production up to 48 hours. Retained local pharmacology of exoIL12 was further confirmed using subcutaneous injections in nonhuman primates. This work demonstrates that tumor-restricted pharmacology of exoIL12 results in superior in vivo efficacy and immune memory without systemic IL12 exposure and related toxicity. ExoIL12 is a novel cancer therapeutic candidate that overcomes key limitations of rIL12 and thereby creates a therapeutic window for this potent cytokine.
Aberrant Induction of a Mesenchymal/Stem Cell Program Engages Senescence in Normal Mammary Epithelial Cells
Authors: Bryson Benjamin L. , Tamagno Ilaria , Taylor Sarah E. , Parameswaran Neetha , Chernosky Noah M. , Balasubramaniam Nikhila , Jackson Mark W.
Published: December 2020

Although frequently associated with tumor progression, inflammatory cytokines initially restrain transformation by inducing senescence, a key tumor-suppressive barrier. Here, we demonstrate that the inflammatory cytokine, oncostatin M, activates a mesenchymal/stem cell (SC) program that engages cytokine-induced senescence (CIS) in normal human epithelial cells. CIS is driven by Snail induction and requires cooperation between STAT3 and the TGFβ effector, SMAD3. Importantly, as cells escape CIS, they retain the mesenchymal/SC program and are thereby bestowed with a set of cancer SC (CSC) traits. Of therapeutic importance, cells that escape CIS can be induced back into senescence by CDK4/6 inhibition, confirming that the mechanisms allowing cells to escape senescence are targetable and reversible. Moreover, by combining CDK4/6 inhibition with a senolytic therapy, mesenchymal/CSCs can be efficiently killed. Our studies provide insight into how the CIS barriers that prevent tumorigenesis can be exploited as potential therapies for highly aggressive cancers.

Implications:

These studies reveal how a normal cell's arduous escape from senescence can bestow aggressive features early in the transformation process, and how this persistent mesenchymal/SC program can create a novel potential targetability following tumor development.
Suppression of MET Signaling Mediated by Pitavastatin and Capmatinib Inhibits Oral and Esophageal Cancer Cell Growth
Authors: Xu Bo , Muramatsu Tomoki , Inazawa Johji
Published: December 2020

Despite increasing knowledge on oral and esophageal squamous cell carcinoma (OSCC and ESCC), specific medicines against both have not yet been developed. Here, we aimed to find novel anticancer drugs through functional cell-based screening of an FDA-approved drug library against OSCC and ESCC. Pitavastatin, an HMGCR inhibitor, emerged as an anticancer drug that inhibits tumor growth by downregulating AKT and ERK signals in OSCC and ESCC cells. One of the mechanisms by which pitavastatin inhibits cell growth might be the suppression of MET signaling through immature MET due to dysfunction of the Golgi apparatus. Moreover, the sensitivity of tumor growth to pitavastatin might be correlated with GGPS1 expression levels. In vivo therapeutic models revealed that the combination of pitavastatin with capmatinib, a MET-specific inhibitor, dramatically reduced tumor growth. Our findings suggest that GGPS1 expression could be a biomarker in cancer therapy with pitavastatin, and the combination of pitavastatin with capmatinib might be a promising therapeutic strategy in OSCC and ESCC.

Implications:

This study provides new insight into the mechanism of pitavastatin as an anticancer drug and suggests that the combination of pitavastatin with capmatinib is a useful therapeutic strategy in OSCC and ESCC.
Double-Balloon Enteroscopy in Detecting Small-Bowel Neuroendocrine Neoplasms: A Single-Center Prospective Study
Authors: Rossi Roberta Elisa , Elli Luca , Branchi Federica , Conte Dario , Massironi Sara
Published: December 2020

Background and Aim: Small-bowel neuroendocrine neoplasm (sbNEN) diagnosis has improved with double-balloon enteroscopy (DBE). DBE efficacy in the detection of sbNENs is unknown. We aimed to report the experience at a single referral center for NENs. Methods: All consecutive patients with a suspected sbNEN selected for diagnostic DBE were enrolled. Results: Between 2011 and 2016, 25 patients were referred for a suspected sbNEN. In 15/25 patients, a primary NEN was detected outside the small bowel; in 4, NEN was excluded. After extensive workup, 6 patients (4 males, median age 50 years) underwent DBE (3 anterograde, 2 retrograde, and 1 both; median time: 60 min; median insertion 200 cm). DBE was positive in 3 patients: one had an ileal 2-cm NEN G1, one had an ileal 1.3-cm NEN G1, and one had an ileal 1-cm NEN G2, all surgically removed. Of the 3 other patients, one had a metastatic NEN of unknown primary, the other two had small intestinal NENs, both surgically removed (1.6-cm G1 and G2 NEN). DBE showed a sensitivity of 60% and, in absence of false-positive results, a specificity of 100%. Accuracy resulted 67%. No complications were observed. Conclusions: In line with data from the literature, the present series showed that DBE is a safe and effective procedure in the diagnosis of sbNENs. Further studies are needed to better clarify the diagnostic role of DBE in the neuroendocrine tumor setting and its relationship with other techniques.
Association between Pre-Existing Coronary Artery Disease and 5-Year Mortality in Stroke Patients with High-Grade Carotid Artery Stenosis
Authors: Wu Ching-I , Wu Chia-Lun , Su Feng-Chieh , Lin Shun-Wen , Huang Wen-Yi
Published: December 2020

Background: The coincidence of coronary artery disease (CAD) and carotid artery stenosis (CAS) was observed. However, the association between pre-existing CAD and ischemic stroke (IS) outcome in patients with high-grade CAS remains unclear. We aimed to investigate the association between pre-existing CAD and outcomes of acute IS patients with high-grade CAS. Methods: From January 1, 2007, to April 30, 2012, we enrolled 372 acute IS patients with high-grade CAS and prospectively observed them for 5 years. Demographic features, vascular risk factors, comorbidities, and outcomes were compared between patients with and without pre-existing CAD. Results: Among 372 individuals, 75 (20.2%) patients had pre-existing CAD and 297 (79.8%) patients did not have pre-existing CAD. The prevalence rates of hypertension, congestive heart failure, chronic kidney disease, and gout in patients with pre-existing CAD were significantly higher than in those without pre-existing CAD (p = 0.017, p < 0.001, p = 0.002, and p < 0.001, respectively). The multivariate Cox proportional hazards model revealed that pre-existing CAD was a significant risk factor for a 5-year all-cause mortality in acute IS patients with high-grade CAS (hazard ratio = 2.26; 95% confidence interval = 1.35–3.79; p = 0.002). Conclusion: Pre-existing CAD was associated with an increased risk of 5-year mortality in acute IS patients with high-grade CAS. Intensive treatment for the pre-existing CAD may reduce long-term mortality in acute IS patients with high-grade CAS.
Population-Based Analysis of the Impact of Demographics on the Current and Future Blood Supply in the Saarland
Authors: Eichler Hermann , Feyer Anna Katharina , Weitmann Kerstin , Hoffmann Wolfgang , Henseler Olaf , Opitz Andreas , Patek Alexander , Hans Detlef Nikolaus , Schönborn Linda , Greinacher Andreas
Published: December 2020

Background: The federal state of Saarland (SL) is experiencing the fastest demographic change in the western part of Germany. In this study, we analyzed retrospective data on the current and future supply of red blood cell concentrates (RBC) in this region and compared it to the current and future RBC demand in SL hospitals. Methods: The projection of the SL blood supply in 2030 was modeled based on SL demographics for age distribution and donation frequency of donors, and the RBC transfusion data for in-house patients. These results were compared to published data on the transfusion demand from the state of Mecklenburg-Western Pomerania (MV). Results: For the period January 1 to December 31, 2017, a total of 43,205 whole blood donations were collected. The donation frequency in SL never exceeded 80 per 1,000 inhabitants and was well below the numbers in MV. Thirty-one percent of the donors were responsible for 53.5% of the donations, and donors older than 45 years of age contributed highly to the total blood supply. In addition, 40,614 RBC transfusions at 10 SL hospitals were analyzed representing nearly all RBC transfusions for in-house patients in this region. RBC transfusions per 1,000 inhabitants increased with age from 24 (50–54) to 140 (80–84) years. Facing an already existing structural deficit of nearly 8,200 RBC in 2017, the projection predicts a dramatic increase in the regional deficit to >18,300 RBC in 2030. Conclusion: Our results on RBC demand in SL are comparable but not identical to those projected for the region of MV in eastern Germany. Due to the ongoing demographic changes in Germany as a whole, regular regional monitoring of RBC demand and the age structure of blood recipients and donors should be implemented to allow for better strategic planning in blood transfusion services and hospitals.
Resenha de O corpo descoberto: contos eróticos brasileiros (1852-1922)
Authors: Resende Ana
Published: December 2020

Resenha do livro O corpo descoberto: contos eróticos brasileiros (1852-1922), organizado por Eliane Robert Moraes.
Tragédia e redenção da personagem da mãe-escrava: uma análise comparativa de Mãe, de José de Alencar, e Cancros Sociais, de Maria Angélica Ribeiro
Authors: Carvalho Jean Bruno
Published: December 2020

O presente artigo tem como finalidade apresentar uma análise comparativa entre a peça Mãe, de José de Alencar (1829 – 1877), e Cancros sociais, de Maria Angélica Ribeiro (1829 – 1880). Tendo sido Maria Ribeiro uma autora pioneira na escrita dramatúrgica feminina e nacional do século XIX, esta análise, além de fortalecer o campo de estudos de ambas as obras, tem também como finalidade apresentar um olhar atencioso sobre uma das obras mais aclamadas da autora, divulgando-a como forma de fortalecer a figura feminina na dramaturgia brasileira. Cancros Sociais pode ser considerada uma dramaturgia-reflexo de Mãe, o que incentiva uma análise, dentre outros aspectos, da construção e do desfecho da personagem da mãe-escrava que, a depender do autor, apresenta temperamentos e atitudes opostos, revelando posições e intenções específicas de cada dramaturgo. Acima de tudo, este é um trabalho que tem como foco duas produções escritas em uma época anacrônica aos tempos atuais, contrastando os pensamentos contemporâneos aos históricos, presentes nas obras analisadas, e exigindo determinado distanciamento para que se possa compreender as obras artísticas a partir das normais sociais e culturais vigentes na época.
Espaços barrocos: da arquitetura irrompe a carne
Authors: Figueiredo Bruna Freitas
Published: December 2020

Pretendemos, nesse texto, esboçar uma leitura da plasticidade, dos tecidos do texto, do corpo e da escultura/arquitetura presentes em Crônica da casa assassinada (1959) e em trabalhos de Adriana Varejão. Entendendo-as como impasses frente à dicotomia alma-corpo e, então, a narrativas morais fundada em um sistema colonial-cristão de dominação, sugerimos que suas propostas estéticas operam de forma a tensionar essa divisão por meio de uma beleza convulsiva da linguagem na qual violência e resistência, repulsa e atração procuram uma conciliação impossível. O efeito desse confronto, assim, nos permite adentrar em um campo no qual o barroco surge, seguindo considerações de Schollhammer ([2007] 2016), como gesto sensível sobre o leitor, promovendo a desestabilização tanto de seus conceitos quanto de sua subjetividade.
Foreign to Palestinian Society? ʿUrfī Marriage, Moral Dangers, and the Colonial Present
Authors: Johnson Penny , Moors Annelies
Published: December 2020

In 2005, religious authorities in Palestine warned publicly of a new phenomenon, one that was ‘foreign to Palestinian society’: ʿurfī marriages. They used this term to refer to ‘secret marriages,’ which they considered as linked to social breakdown, the result of the Israeli occupation. In the tales (similar to rumors) of young men and women throughout the West Bank and Gaza in the early 2010s, these marriages were often related to the colonial geographies of anxiety, of social and political fragmentation, and of the spatial segregation that Israel has imposed on Palestinians. Related concerns were expressed by the men of religion as they attempted to maintain their authority in highly uncertain times and in contested spaces. Still, in the very small number of concrete cases shariʿa judges continued to use the flexibility of Islamic jurisprudence to legally recognize ʿurfī marriages to work towards the most equitable solution in problematic situations.
Decomposing the Drivers of Polar Amplification with a Single-Column Model
Authors: Henry Matthew , Merlis Timothy M. , Lutsko Nicholas J. , Rose Brian E. J.
Published: December 2020

The precise mechanisms driving Arctic amplification are still under debate. Previous attribution methods compute the vertically uniform temperature change required to balance the top-of-atmosphere energy imbalance caused by each forcing and feedback, with any departures from vertically uniform warming collected into the lapse-rate feedback. We propose an alternative attribution method using a single-column model that accounts for the forcing dependence of high-latitude lapse-rate changes. We examine this method in an idealized general circulation model (GCM), finding that, even though the column-integrated carbon dioxide (CO2) forcing and water vapor feedback are stronger in the tropics, they contribute to polar-amplified surface warming as they produce bottom-heavy warming in high latitudes. A separation of atmospheric temperature changes into local and remote contributors shows that, in the absence of polar surface forcing (e.g., sea ice retreat), changes in energy transport are primarily responsible for the polar-amplified pattern of warming. The addition of surface forcing substantially increases polar surface warming and reduces the contribution of atmospheric dry static energy transport to the warming. This physically based attribution method can be applied to comprehensive GCMs to provide a clearer view of the mechanisms behind Arctic amplification.
Evaluation of KDP Estimation Algorithm Performance in Rain Using a Known-Truth Framework
Authors: Reimel Karly J. , Kumjian Matthew
Published: December 2020

Accurate estimation of specific differential phase (KDP) is necessary for rain rate estimation, attenuation correction, and hydrometeor classification algorithms. There are numerous published methods to process polarimetric radar observations of propagation differential phase shift (ΦDP) and estimate KDP, but the corresponding KDP estimate uncertainty is unquantified. This study provides guidance on how commonly used KDP estimation algorithms perform in various environments. We create numerous synthetic (“true”) KDP profiles, integrate over them to obtain “smoothed” ΦDP, and then add noise typical of S-band operational weather radar measurements. Each algorithm is applied to our noisy ΦDP profiles and compared to the true KDP profile such that the errors and uncertainty are quantified. The synthetic KDP profiles are Gaussian in shape, which allows systematic variations in their magnitude and width to determine how each algorithm performs in smooth, slowly changing KDP profiles, as well as steep profiles. Results demonstrate that algorithm performance is dependent on the ΦDP field received. These results are further supported by an error analysis of each algorithm for two more complicated synthetic KDP profiles. Some KDP algorithms allow users to change various tuning parameters; a subset of these tuning parameters is tested to provide guidance on how changing these parameters impacts algorithm performance. We then provide evidence that our known-truth framework provides insight into algorithm performance in observed data through two case studies.
Observing System Simulation Experiments Investigating Atmospheric Motion Vectors and Radiances from a Constellation of 4–5-μm Infrared Sounders
Authors: McCarty Will , Carvalho David , Moradi Isaac , Privé Nikki C.
Published: December 2020

A set of observing system simulation experiments (OSSEs) was performed to investigate the utility of a constellation of passive infrared spectrometers, strategically designed with the aim of deriving the three-dimensional retrievals of the horizontal wind via atmospheric motion vectors (AMVs) from instruments with the spectral resolution of an infrared sounder. The instrument and constellation designs were performed in the context of the Midwave Infrared Sounding of Temperature and humidity in a Constellation for Winds (MISTiC Winds). The Global Modeling and Assimilation Office OSSE system, which includes a full suite of operational meteorological observations, served as the control. To illustrate the potential impact of this observing strategy, two experiments were performed by adding the new simulated observations to the control. First, perfect (error free) simulated AMVs and radiances were assimilated. Second, the data were made imperfect by adding realistic modeled errors to the AMVs and radiances that were assimilated. The experimentation showed beneficial impacts on both the mass and wind fields, as based on analysis verification, forecast verification, and the assessment of the observations using the forecast sensitivity to observation impact (FSOI) metric. In all variables and metrics, the impacts of the imperfect observations were smaller than those of the perfect observations, although much of the positive benefit was retained. The FSOI metric illustrated two key points. First, the largest impacts were seen in the middle troposphere AMVs, which is a targeted capability of the constellation strategy. Second, the addition of modeled errors showed that the assimilation system was unable to fully exploit the 4.3-μm carbon dioxide absorption radiances.
An Umbrella Review of Text Message Programs for Adults With Type 2 Diabetes
Authors: Whittemore Robin , Siverly Lauren , Wischik Dora Lendvai , Whitehouse Christina R.
Published: December 2020

Purpose

The purpose of this umbrella review was to synthesize the evidence from published systematic reviews on the effectiveness of text message programs for adults with type 2 diabetes (T2DM) on glycemic management (A1C), self-management, and other clinical outcomes. The effect of directionality of the program was also explored.

Methods

A systematic search was conducted using multiple databases. Inclusion criteria were systematic review of text message programs for adults with T2DM, evaluated A1C, and English language. Quality assessment was completed using AMSTAR-2 guidelines. Data were extracted by multiple coders, and results were synthesized.

Results

The final sample included 9 systematic reviews published between 2011 and 2019, with 72 unique international studies. Text message programs focused on diabetes self-management and reducing health risks through educational and motivational content with some providing personalized feedback. A meta-analysis of program effect on A1C was conducted in 5 reviews with a pooled difference in A1C from −0.38% to −0.8%. Adults with T2DM of shorter duration and lower A1C had better treatment effects. Evidence on unidirectional versus bidirectional programs is conflicting; however, both improve outcomes. Evidence of text message programs targeting medication engagement was inconclusive. Some programs improved blood pressure, lipids, self-management, self-efficacy, and health behaviors. High satisfaction and an average of 9.6% to 18.7% attrition was reported.

Conclusions

Text messaging programs can improve T2DM outcomes, are a highly accessible mode of communication, are relatively inexpensive, and are an underutilized adjunct to clinical care.
Early Maladaptive Schemas Are Highly Indicative of Compulsive Sexual Behavior
Authors: Efrati Yaniv , Shukron Ortal , Epstein Robert
Published: December 2020

Unlike the consequences of compulsive sexual behavior (CSB) and the profile of people with CSB that were extensively studied, the cognitive distortions that might be responsible to the development and maintenance of CSB are less understood. In Study 1 ( n = 68), we examined intercorrelations between CSB and early maladaptive schemas among a sample with clinical CSB (Sexaholic Anonymous; SAs). In Study 2 (sex offenders; n = 103, and violence offenders; n = 81), we examined the intercorrelations between CSB and early maladaptive schemas among a sample with a sexual deviance but non-clinical levels of CSB. Results revealed that early maladaptive schemas are highly indicative of CSB severity. We discuss the implication of the study for the study and therapy of CSB.
Transfer of Early to Late Adolescents’ Attachment Figures in a Multicohort Six-Wave Study: Person- and Variable-Oriented Approaches
Authors: Umemura Tomotaka , Lacinová Lenka , Juhová Dana , Pivodová Lenka , Cheung Hoi Shan
Published: December 2020

Although Bowlby proposed that adolescence is a major developmental period to transfer their attachment figures from parents to other people, no comprehensive longitudinal study on attachment transfer from early to late adolescence exists. This study employed 215 early to late adolescents between ages 11 and 18 years ([Formula: see text] = 14.02, SD = 2.05 at Wave 1), using a six-wave 2-year longitudinal design with four different cohorts: 5th, 7th, 9th, and 11th grades. Both person- and variable-oriented analyses revealed that once adolescents have transferred their attachment figures from parents to peers, they were unlikely to revert to parents in the future. The transfer of attachment from parents to friends is more prevalent in early adolescence than in late adolescence. However, throughout adolescence, friends were not considered to be exclusive attachment figures, whereas parents and romantic partners were. Finally, many adolescents spent 4 months or fewer until their romantic partner became the primary attachment figure.
Successive ipsilateral surgery of Vibrant Soundbridge and Bonebridge devices for congenital bilateral conductive hearing loss: a case report
Authors: Liu Yujie , Ren Ran , Zhao Shouqin
Published: December 2020

The Bonebridge and Vibrant Soundbridge systems are semi-implanted hearing devices, which have been widely applied in patients with congenital conductive hearing loss. However, comparison between these two hearing devices is rare, especially in the same patient. We report a 23-year-old man who underwent successive implantation of Vibrant Soundbridge and Bonebridge devices in the same ear because of dysfunction of the Vibrant Soundbridge. We provide insight on the patient’s experience and compare the audiological and subjective outcomes of satisfaction.
Acute pancreatitis after the removal of a hyperplastic duodenal polyp: a case report
Authors: Mirchev Milko , Atanasova Silvia , Gancheva Diana , Hahne Jens Claus , Kotzev Andrei , Georgiev Nikolay
Published: December 2020

A 59-year-old patient underwent the duodenal endoscopic mucosal resection of a hyperplastic polyp. Four hours after the procedure she developed severe epigastric pain. Laboratory and imaging results were consistent with mild acute edematous pancreatitis. After several days of dietary therapy and intravenous crystalloid fluids the patient recovered, and 1 month later was asymptomatic and had no signs of pancreatic inflammation. This case illustrates a rare but clinically important complication of therapeutic upper endoscopy, which may be attributable to thermal injury of the duodenal wall and the adjacent pancreas. It also underscores the importance of the close follow up of patients who undergo invasive endoscopic procedures and the need for additional preventive measures to be taken when resecting duodenal lesions.
Exploring young children’s activity and participation change following 6 months’ power mobility experience
Authors: Livingstone Roslyn W , Field Debra A
Published: December 2020

Introduction

This pre-post study explored the effect of children’s 6 months’ experience in one of four early power mobility devices.

Method

Satisfaction with parent-selected goal achievement was measured using the wheelchair outcome measure for young people and compared with the assessment of learning powered mobility use, as well as device expectation fulfilment ratings.

Results

Forty-six children with mobility limitations, aged 13–68 months (mean 40.40; SD 15.60) participated. The most common condition was cerebral palsy ( n = 33; 71.74%). The Wilcoxon signed rank test measured the positive change in goal achievement ( z = 4.90; P<0.001; r = 0.51). Fair to good statistically significant Spearman’s correlations were observed between power mobility skill and goal achievement, as well as parent and therapist device expectation scores ( rs = 0.48, 0.46 and 0.66, respectively; P<0.001). Parent and therapist ratings did not differ significantly. No statistically significant associations were found between goal achievement and child (age, diagnosis, abilities) or environmental factors (device, access method, loan length).

Conclusion

Children at all phases of power mobility skill, using various devices and access methods, can demonstrate activity and participation change following power mobility experience. This study adds validity evidence supporting the use of the wheelchair outcome measure for young people with young children by parent-proxy rating.
The Implications of the Triumph of Neoclassical Economics over Marxist Economics in China
Authors: Cohn Steve
Published: December 2020

This paper explores the implications of one of the great intellectual revolutions of the late twentieth and early twenty-first centuries, the replacement of Marxist economics by neoclassical economics in China. The analysis summarizes what is distinctive about Marxist and neoclassical ways of thinking. The paper then demonstrates how these differences led to different framings and different conclusions about a number of key topics related to the development of capitalism in China. Among the topics explored are the merits of state-owned enterprises, the nature of inequality in China, and the relationship between capitalism and the environment. The paper concludes with a discussion of the different policy agendas that emerge from the different framings offered by neoclassical and Marxist economics.

JEL Classification: B41, B51, P2, O53
Integrating Workforce Health Into Employer Diversity, Equity and Inclusion Efforts
Authors: Sherman Bruce W. , Kelly Rebecca K. , Payne-Foster Pamela
Published: December 2020

Our collective experience with COVID-19 and Black Lives Matter has heightened awareness of deeply embedded racial and socioeconomic disparities in American businesses. This time, perhaps, sustained change is within reach. As organizations advance diversity, equity and inclusion (DEI) initiatives, an often overlooked focus of is the health status of employees and their families, where equitable access to high-value health benefits offerings should be available to all. This commentary provides guidance for employers to expand their DEI initiatives to include employee and family health and well-being as a central outcome measure. Employers should ensure that DEI efforts incorporate equitable benefits design, and objectively assess benefit design impact on healthcare utilization and cost. Additionally, employers must appreciate the workplace as a significant determinant of health—for lower income workers, in particular—with review of policies and practices to mitigate any discriminatory negative health or well-being impact. Further, race and ethnicity data should be incorporated in health benefits data analysis to understand more clearly the differential outcomes of health management offerings on these different sub-populations. Finally, social needs data should be incorporated into strategic benefits planning to better understand gaps and opportunities to foster greater benefits equity. The provided recommendations can support employer goals of achieving greater equity and value in workforce health, measurably contributing to business success.
Academic Integrity Policies of Publicly Funded Universities in Western Canada
Authors: Stoesz Brenda M. , Eaton Sarah Elaine
Published: December 2020

We examined 45 academic integrity policy documents from 24 publicly-funded universities in Canada’s four western provinces using a qualitative research design. We extracted data related to 5 core elements of exemplary academic integrity policy (i.e., access, detail, responsibility, approach, support). Most documents pointed to punitive approaches for academic misconduct and were based on the notion that academic misconduct results from a lack of morals. One university used the term “contract cheating,” although nearly all categorized the outsourcing of academic work as plagiarism. Details about educational resources and supports to increase student and staff understanding of academic integrity and prevention of academic misconduct were sparse. This study signals the continuing punitive nature of academic integrity policies in western Canadian universities, the reluctance to address contract cheating directly, and the need to revise policies with deeper consideration of educative approaches to academic integrity that support students and academic staff.
Impact of a Systematic Pharmacist-Initiated Antibiotic Time-Out Intervention for Hospitalized Adults
Authors: Paulson Calley M. , Handley Jillian F. , Dilworth Thomas J. , Persells Dan , Prusi Rachael Y. , Brummitt Charles F. , Torres Katherine M. , Skrupky Lee P.
Published: December 2020

Introduction:

Antibiotic time-outs (ATO) are a recommended antimicrobial stewardship action, but data assessing their impact are lacking. This study investigated the impact of a systematic, pharmacist initiated ATO intervention.

Methods:

This pre-post study included inpatients on hospitalist and intensivist services receiving empiric antibiotics for ≥48 hours. The ATO was initiated by pharmacists after 48 hours of empiric therapy and the outcome was documented including antibiotic indication, plan, and duration. An electronic medical record (EMR) alert facilitated ATO completion and pharmacists and prescribers received education prior to implementation. The primary outcome was EMR documentation of an antibiotic plan by 72 hours. Secondary outcomes included antibiotic utilization and antibiotic therapy modifications by 2 hours.

Results:

399 patients were included, 199 pre- and 200 post-intervention. The most common indications were pneumonia (32%), intra-abdominal infection (20%) and urinary tract infection (19%), with no between-group differences. EMR documentation of an antibiotic plan significantly improved in the post-intervention group (19% vs. 79%, p<0.0001) as did modifications to antibiotic therapy. The median duration of in-hospital antibiotic therapy was similar between groups (4.0 vs. 4.0 days, p = 0.2499). Approximately 45% of patients in each group received discharge antibiotics and median duration of discharge antibiotic therapy prescribed was reduced (7 vs. 5 days in the pre- and post-intervention groups, respectively; p = 0.0140).

Discussion:

Implementation of pharmacist initiated ATO was associated with improvements in supporting EMR documentation and antibiotic therapy modifications. These findings highlight an important role in which pharmacists can serve as part of a collaborative antibiotic stewardship team.
Structure and properties of BPDA/PDA polyimide fibers
Authors: Jiang Ming , Yuan Dongming , Han Enlin , Zhang Mengying , Jing Sheng , Niu Hongqing , Wu Dezhen
Published: December 2020

Polyimide/graphene (PI/G) composite fibers containing p-phenylenediamine ( p-PDA), 3,3′,4,4′-Biphenyl tetracarboxylic diandhydride (BPDA) and graphene (G) were prepared by wet spinning and thermal imidization. The mechanical properties, thermal stability, orientation factor and morphology of PI/G composite fibers were characterized and studied. Within the scope of the study, the tensile strength and tensile modulus of the fibers increased first and then decreased with the increase of the graphene content. Moreover, the glass transition temperature and thermal decomposition temperature of the PI/G composite fibers increased with the increased of the graphene content. X-ray diffraction (XRD) showed that the degree of orientation of the of prepared fibers increase firstly and then decrease with the content of graphene increasing. SEM indicated that graphene was dispersed evenly in the PI/G composite fibers and graphene had satisfactory compatibility with PI matrix.
Algorithm for computing the connectivity in planar kinematic chains and its application
Authors: Yang Wenjian , Ding Huafeng , Kecskemethy Andres
Published: December 2020

The number of synthesized kinematic chains usually is too large to evaluate individual characteristics of each chain. The concept of connectivity is useful to classify the kinematic chains. In this paper, an algorithm is developed to automatically compute the connectivity matrix in planar kinematic chains. The main work is to compute two intermediate parameters, namely the minimum mobility matrix and the minimum distance matrix. The algorithm is capable of dealing with both simple-jointed and multiple-jointed kinematic chains. The present work can be used to automatically determine kinematic chains satisfying the required connectivity constraint, and is helpful for the creative design of mechanisms. The practical application is illustrated by taking the face-shovel hydraulic excavator for instance.
Sociodemographic and clinical variables associated with discharge under compulsory treatment orders
Authors: Dey Sangeeta , Mellsop Graham , Obertova Zuzana , Jenkins Matthew
Published: December 2020

Objective:

To document the sociodemographic and clinical variables associated with discharge under compulsory treatment orders in patients with schizophrenia or related disorders.

Method:

Information on various sociodemographic and clinical variables were extracted from the clinical files of 349 patients discharged from an adult (age 18–65) inpatient psychiatric unit with diagnoses of schizophrenia or related disorders. Univariate and multiple logistic regression analyses with legal compulsion (compulsory versus voluntary) as outcomes were applied.

Results:

Two hundred of the 349 discharged patients were placed under compulsory treatment orders. In the univariate logistic regression analysis, unemployment, diagnosis of schizophrenia, forensic history, dosage of antipsychotics, prescription and frequency of injectable antipsychotics, polypharmacy and a hospital stay of more than 28 days were associated with compulsory status. Being married or in partnership and living with partner was associated with voluntary status. Multiple regression models respectively confirmed most of these relationships observed in the univariate analyses.

Conclusion:

Clarification of the apparent drivers for compulsory treatment may help thoughtful reductions in the use of compulsion.
Bilateral diabetic papillopathy developed after starting insulin treatment. Potential toxic effect of insulin? A case report
Authors: Mafrici Marco , Toscani Laura , Lorenzi Umberto
Published: December 2020

Background:

Diabetic papillopathy is a complication of diabetes. It presents with edema, uni or bilateral and vascular alteration of the anterior optic nerve. Often this complication is observed in patients with severe diabetic retinopathy, but is rarely observed in isolated form. Some authors believe that diabetic papillitis is a particular form of non-arteritic anterior ischemic optic neuropathy (NAION). But there is important evidence that confers an inflammatory component to diabetic papillopathy. We report in this work a rare case of isolated acute bilateral diabetic papillopathy developed in a diabetic patient after adding the insulin to the oral hypoglycemic therapy.

Case presentation:

Male patient, 49-years-old, diabetic type 2, with altered glycemia at follow up, with clinical history of HbA1c 8% to 12% in the last 2 years, on oral hypoglycemic therapy for 10 years. He never had a history of diabetic retinopathy. At the last check-up, this patient presented bilateral papillopathy, without reduction of visual acuity bilaterally. The patient reports he added 10 days before the insulin therapy to the oral hypoglycemic therapy, under medical supervision. Hematochemical and serological tests were requested, which excluded the presence of inflammatory and infectious diseases. The brain magnetic resonance imaging (MRI) with gadolinium excluded the hypothesis of optic neuritis or intracranial hypertension. Cardio-circulatory tests were normal. Fluorescein angiographic examinations and optical coherence tomography (oct) confirmed the bilateral edema and the thickening of optic nerve without other retinal damage. Therefore he was diagnosed with bilateral diabetic papillopathy. Then, diabetologists added pump insulin treatment to the oral hypoglycemic therapy. After 2 months, his blood sugar levels and HbA1C improved and papillopathy regressed.

Conclusion:

We have reported a rare case of bilateral acute diabetic papillopathy associated with the addition of insulin to the oral hypoglycemic therapy. A randomized control study with diabetic patients, would be useful to verify the possible injuries of the optic nerves during the delicate transition to insulin therapy.
Are laws the appropriate solution: The need to adopt non-policy measures in aid of the implementation of sex discrimination laws in Nigeria
Authors: Okongwu Onyeka C
Published: December 2020

Gender inequality is a social problem facing women all over the world and is a barrier to human development. The United Nations commits to achieving gender equality and empowering women and girls and have adopted the Sustainable Development Goals to achieve gender equality by 2030. Nigeria, a Member State of the United Nations has ratified international and regional instruments which advocate for the protection and promotion of the rights of women and girls. Though some progress has been made to reduce inequality, discrimination remains a problem to women and is exacerbated by factors such as culture, religion, social practices and discriminatory laws. This study seeks to add to the discourse on gender inequality in Nigeria and examine the effectiveness of available domestic and international provisions against sex discrimination when considered against ingrained cultural attitudes, beliefs and discriminatory laws. The study found that among other determinants, culture and religion were constant features in the different forms of discrimination Nigerian women face and they were the primary reasons the proposals to pass gender equality laws were opposed and failed. The study proposes the need to adopt non-policy measures such as education and awareness-raising as additional measures to eliminating discrimination and promoting equality.