bluuebunny/crossref_metadata_2025 huggingface dataset:
Prenatal echocardiography diagnosis of Ebstein’s anomaly at 11-14 weeks of gestation: the
first results of multicenter study
Authors: M.V. Medvedev , I.V. Komarova , N.A. Altynnik
Published: April 2019

Retrospectively, as a result of fetus’ ultrasound screening at 11–14 weeks of gestation, 30 cases of diagnosis of Ebstein’s anomaly
(EA) were analyzed. Among these cases — 8 were detected and 22 non-detected. The resulting quality of prenatal ultrasound diagnosis of
EA at 11–14 weeks of gestation is equal to 26,7 %. The average value of nuchal translucency thickness among the all group of 30 fetuses
is equal to 2,97 mm. Only in 6 cases (20 %) this marker exceeds 3 mm, including 3 cases of cystic hygroma. In most cases nasal bone was
detected and was estimated as “+”. The heart rate was normal, the cardiac arrhythmia was not detected. EA diagnosis in early pregnancy was
based on searching the clinical features of fetus’ 4-chamber cardiac view: cardiac axis deviation to the left, right atrium extension, tricuspid
valve displacement, and expressed tricuspid regurgitation. These features were diagnosed in all 8 cases. Combined extracardiac pathology
was presented in 3 cases as cystic hygroma, that equals 9,6 %. In one case chromosomal pathology was detected (trisomy 21), but only in
7 cases the fetus’ karyotype was defined. Among the combined congenital heart disease, detected in more than the half of the cases of the
late diagnosis, the obstructive lesions of pulmonary artery (PA) have the prevalence. The estimations, we made, of cardiothoracic index
calculation, as a marker of cardiomegaly at EA at 11–14 weeks of gestation, were ineffective. More value for diagnosis of disproportion
cardiac chambers had the ratio of right ventricle width to left ventricle width, in that cases in which that ratio increases 1,5 (62,5 % cases).
Cardiac axis left deviation was detected in 87,5 % cases, the average deviation was 83°. The average index Celermajer was equal to 1,08 and
in the 50% of cases was combined with high risks of infant mortality.
Prenatal diagnosis of urinoma
Authors: O.I. Guseva , A.N. Baratova , L.E. Egorskaya
Published: April 2019

Objective: to evaluate the functional ability of the kidneys in patients with prenatally diagnosed urinoma
Materials: we retrospectively reviewed 2 cases of antenatally diagnosed urinoma. With the aim of establishing the overall prognosis prenatally diagnosed urinoma we reviewed the literature on the subject. The analysis
included 38 published cases of prenatal urinoma detection followed by newborn follow-up.
260 Пренатальная диагностика уриномы 2018 Т 17 № 3; 255-260 ПРЕНАТАЛЬНАЯ ДИАГНОСТИКА
Конфликт интересов: отсутствует.
Прозрачность финансовой деятельности: никто из авторов не имеет финансовой заинтересованности в
представленных материалах или методах.
Для цитирования: Гусева О.И., Баратова А.Н., Егорская Л.Е. Пренатальная диагностика уриномы. Пренат. Диагн. 2018; 17(3): 255–260. doi: 10.21516/2413-1458-2018-17-3-255-260
Results: urinoma was diagnosed at 32 and 33 weeks of pregnancy. The development of children was traced
to 5 and 7 months. In the case of urinoma of large size, there was no renal function after birth. According to
the literature review, renal function was retained after birth in only 8 of 38 children (21 %).
Conclusion: urinoma is a rare serious complication that indicates significant damage to the kidney after
obstruction, which often leads to a violation or absence of the function of the affected kidney. If the diagnosis
of urinoma was in prenatal life, it is important to inform parents about the bad prognosis.
Prediction and prevention of pre-eclampsia and fetal growth restriction
at 11–14 weeks of gestation: analysis of 1001 cas
Authors: M.V. Medvedev, N.A. Altynnik, P.V. Knyazev
Published: April 2019

This was a retrospective analysis of 1001 women at 11 to 14 weeks’ gestation screened for pre-eclampsia
(PE) and intrauterine growth restriction (IUGR) using specialized program, including data history, blood
pressure, biochemical markers (PAPP-A, PLGF) and pulsatility index in uterine arteries. 55 high-risk women
offered aspirin (150 mg at night). There are no cases of PE in low-risk 946 women and IUGR was in 3 (0,32
%) cases. In high-risk first subgroup only 3 (8,6 %) from 35 women offered aspirin 150 mg at night delivering
babies with IUGR and there are no cases of PE in this subgroup. In high-risk second subgroup 9 (45%) from
20 women without aspirin delivering babies with IUGR and 2 (10 %) with PE. A strategy of first-trimester
screening for PE and IUGR with prescription of aspirin to the high-risk group appears to be effective in reducing the prevalence of PE and IUGR
A case of atypical multicystic dysplastic kidney in the fetus
Authors: S.V. Idimesheva, E.G. Bazhenova, J.P. Popova et all
Published: April 2019

This article describes a case of the dynamic ultrasound examination of multicystic dysplasia of the fetal left kidney from 20 weeks of gestation until the birth. The huge enlargement of one of the cysts with an
abdominal compression was revealed at 24–25 weeks of gestation. The aspiration of the contents of the cyst
was performed triples. The cyst regression was marked at 36–37 weeks of gestation. The postnatal ultrasound
examination confirmed the multicystic dysplasia of the left kidney.
A felnőtteket ellátó háziorvosok által végzett kardiometabolikus rizikófaktorszűrés és influenza elleni vakcinálás hatékonysága Magyarországon 2014-ben
Authors: Sándor János , Czifra Árpád
Published: April 2019

Az alapellátás preventív szolgáltatásai segítségével jelentősen csökkenthető a legnagyobb népegészségügyi súlyú betegségek okozta egészségveszteség, de ezeknek a lehetőségeknek a kiaknázására csak részben került sor. A 2014-es Európai Lakossági Egészségfelméréshez kapcsolódó magyarországi vizsgálat lehetőséget adott arra, hogy értékeljük az alapellátás szintjén nyújtható hipertónia-, cukorbetegség- és hiperkoleszterinémia-szűrés, valamint az influenza elleni vakcinálás hatékonyságát. Meghatároztuk a szakmai irányelveknek megfelelő ellátás, illetve ellátási hiány gyakoriságát, és regressziós modellek segítségével vizsgáltuk az ellátás hiányának rizikófaktorait. A hipertónia, a cukorbetegség és a hiperkoleszterinémia szűrése az egyes célcsoportokban 63–80, 45–63 és 29–68%-os gyakorisággal valósult meg. Influenza elleni védőoltást a célcsoportokba tartozók 9–23%-a kapott. Mindez 1,87 millió évente elmaradt vérnyomásmérésnek, 2,17 millió elmaradt vércukorszint-ellenőrzésnek, 3,17 millió elmaradt koleszterinszint-meghatározásnak és 3,25 millió elmaradt influenza elleni védőoltásnak felelt meg országos szinten. Összességében minden célcsoportban és mindegyik preventív szolgáltatás esetében elmaradtak az igénybevételi adatok az ajánlottaktól; a szolgáltatások hatékonyságának növelése szempontjából az általános célcsoportot a háziorvosi rendelőbe nem járó felnőttek jelentették, akik elérése érdekében az alapellátóknak aktív szervezési munkát kellene végezniük.
Családbővítési intenciók - a harmadik gyermek vállalásának szándéka
Authors: Árki Diána
Published: April 2019

A tanulmány a paritás-specifikus termékenységi döntések folyamatának vizsgálatára, mindenekelőtt a harmadik gyermek vállalására irányuló szándék közelebbi megértésére törekszik. A felvázolt elméleti keret és az empirikus elemzés révén magyarázatot kaphatunk arra a kérdésre, hogy a kétgyermekes nők mely jellemvonásai befolyásolják a harmadik gyermek világrahozatalának szándékát: Milyen módon hatnak a személyek strukturális pozíciói (1.), értékei (2.), valamint jövőirányultságára utaló nézetei (3.) arra, hogy kívánnak-e az egyének harmadik utódot? Többváltozós elemzésemet logisztikus regressziós módszer alkalmazásával valósítottam meg a KSH Népességtudományi Kutatóintézet, Életünk fordulópontjai társadalmi-demográfiai adatfelvétel első (2001/2) adatfelvételi hullámának felhasználásával. Eredményeim szerint az ezredfordulót követően azok a 30 év alatti, egyház tanításait követő, azonos nemű gyermekeket nevelő nők szerették volna bővíteni családjukat, akik nagyobb településen (Budapesten vagy megyei jogú városban), nem családi házban éltek, és a munka iránt kevésbé elkötelezettek. Mindezek következtében előzetes feltevéseim közül több hipotézisem igazolást nyert, ugyanakkor az eredmények számos feltételezésemet megcáfolták.
Interaction of spherical gas bubbles in liquid
Authors: Aganin A.A. , Davletshin A.I. , Malakhov V.G.
Published: April 2019

A mathematical model of interaction of two spherical gas bubbles in liquid is proposed. This model is a system of ordinary differential equations of the second order in the radii of bubbles and the spatial positions of their centers. It differs from the analogues known in the literature in that it allows much smaller distances between interacting bubbles.
Vapor bubble growth with a high value of overheating
Authors: Aktershev S.P. , Ovchinnikov V.V.
Published: April 2019

The numerical simulation of the growth of a vapor bubble in inhomogeneously heated liquid is performed; the influence of the temperature inhomogeneity on the bubble dynamics is investigated. The calculations are compared with experimental data for a vapor bubble growing on a cylindrical heater. At high overheating, the results of the calculations are in satisfactory agreement with experimental data for the initial stage of growth of the vapor bubble. In the presence of evaporation fronts, the measured bubble radius values exceed the calculated values. This excess can be explained by the inflow of vapor to the bubble from the evaporation front.
Algorithm for diagnosing fastenings of pipe with liquid
Authors: Akhtyamov A.M. , Safina F.F.
Published: April 2019

An algorithm is considered for diagnosing fastening of a narrow tube filled with a fluid by a spectrum of natural frequencies of its bending vibrations. The constructed algorithm, based on the solution of systems of algebraic equations, allows one to determine any pipe fastenings by 9 values from the frequency spectrum of its vibrations when the liquid is flowing through the pipe.
Focusing of inertial particles after the shock-wave intersection point
Authors: Golubkina I.V.
Published: April 2019

The effect of the aerodynamic focusing of inertial particles is investigated in both symmetric and non-symmetric cases of interaction of two plane shock waves in the stationary dusty-gas flow. The particle mass concentration is assumed to be small. Particle trajectories and concentration are calculated numerically with the full Lagrangian approach. A parametric study of the flow is performed in order to find the values of the governing parameters corresponding to the maximum focusing effect.
Integrable two-dimensional dynamical systems and the characteristic Lie algebras
Authors: Zhiber A.V. , Kostrigina O.S.
Published: April 2019

In the paper it is shown that the two-dimensional dynamical system of equations is Darboux integrable if and only if its characteristic Lie algebra is finite-dimensional. The class of systems having a full set of fist and second order integrals is described.
Gravity convection of suspensions and aerosols in closed vessel
Authors: Nevsky Yu.A.
Published: April 2019

Within the framework of the model of interpenetrating continuums, the problem of gravitational convection of a dispersed suspension in a closed two-dimensional vessel is considered. On the example of the problem of gravitational settling (emersion) of a heavy (light) spherical particle in the harmonic velocity field of a viscous carrier phase, the influence of non-stationary and ”historical“ forces on the particle motion is investigated. A hydrodynamic model of gravitational convection of suspensions and aerosols is developed, which takes into account non-stationary forces in the interphase momentum exchange. A range of parameters, in which the description of mesoscale motions in a settling (floating) suspension is impossible without taking into account non-stationary and historical forces, is determined.
Convergence of a thin spherical shell
Authors: Khabirov S.V. , Garifullin A.R.
Published: April 2019

The precise solution of equations of motion of a true liquid describing a convergence to the center of a thin spherical shell is considered. At the initial stage prime asymptotic formulas which are used for studying of a dynamic stability in relation to potential indignations are received.
Effect of Simultaneous Snail Slime-aided Degradation and Yeast Fermentation on Terpenoid Composition of Plantain Pseudostem Waste
Authors: Uchenna Amadi P. , Charity Ogunka-Nnoka , Abbey Bene
Published: April 2019

Background:

In this study, local sustainable enzyme sources involving excised digestive
juice of African land snail and yeast were utilized to achieve the simultaneous saccharification (SSF)
and fermentation (SSF) of plantain pseudostem (PPS) waste, and afterwards their effects on terpenoids
using gas chromatography coupled to a flame ionization detector (GC-FID), were examined.

Methods:

The most abundant terpenoids were found in the order α-pinene > borneol > camphor > humulene
> β-caryophellene, while the least in abundance were cis ocimene (8.78x10-6 mg/100g), and
cyperene (1.81x10-5 mg/100g). The application of exclusive fermentation and SSF respectively elevated
azuluene by 95.46 and 99.6%, while pinene-2-ol was elevated by 83.02 and 98.57%, respectively.

Results:

Both exclusive fermentation and SSF had no effect on myrcene, cyperene, ethyl cinnamate,
germacrene b, valencene, beta selinene, aromadendrene, and taraxerol, while the degree of degradation
of some of the terpenoids by both processes was respectively as follows; gama muurolene (100%),
β-caryophyllene (97.60 and 93.14%), α-terpinenyl acetate (91.95 and 83.16%), geranyl acetate (94.81
and 43.87%), and terpinen-4-ol (94.40 and 57.00%).

Conclusion:

The findings of this study encourage the imminent application of simultaneous saccharification
and fermentation for the enhancement of bioactivities of terpenoids.
Targeting p53-MDM2 Interaction Using Small Molecule Inhibitors and the Challenges Needed to be Addressed
Authors: Zanjirband Maryam , Rahgozar Soheila
Published: April 2019

MDM2 protein is the core negative regulator of p53 that maintains the cellular levels of p53 at a low level in normal cells. Mutation of the TP53 gene accounts for 50% of all human cancers. In the remaining malignancies with wild-type TP53, p53 function is inhibited through other mechanisms. Recently, synthetic small molecule inhibitors have been developed which target a small hydrophobic pocket on MDM2 to which p53 normally binds. Given that MDM2-p53 antagonists have been undergoing clinical trials for different types of cancer, this review illustrates different aspects of these new cancer targeted therapeutic agents with the focus on the major advances in the field. It emphasizes on the p53 function, regulation of p53, targeting of the p53-MDM2 interaction for cancer therapy, and p53-dependent and -independent effects of inhibition of p53-MDM2 interaction. Then, representatives of small molecule MDM2-p53 binding antagonists are introduced with a focus on those entered into clinical trials. Furthermore, the review discusses the gene signatures in order to predict sensitivity to MDM2 antagonists, potential side effects and the reasons for the observed hematotoxicity, mechanisms of resistance to these drugs, their evaluation as monotherapy or in combination with conventional chemotherapy or with other targeted therapeutic agents. Finally, it highlights the certainly intriguing questions and challenges which would be addressed in future studies.
Is Brain-Derived Neurotrophic Factor: A Common Link Between Neurodegenerative Disorders and Cancer?
Authors: Khosla Radhika , Banik Avijit , Kaushal Sushant , Battu Priya , Gupta Deepti , Anand Akshay
Published: April 2019

Background:

Cancer is a common disease caused by the excessive proliferation of cells, and
neurodegenerative diseases are the disorders caused due to the degeneration of neurons. Both can be
considered as diseases caused by the dysregulation of cell cycle events. A recent data suggests that
there is a strong inverse association between cancer and neurodegenerative disorders. There is indirect
evidence to postulate Brain-derived Neurotrophic Factor (BDNF) as a potential molecular link in this
association.

Discussion:

The BDNF levels are found to be downregulated in many neurodegenerative disorders and
are found to be upregulated in various kinds of cancers. The lower level of BDNF in Alzheimer’s and
Parkinson’s disease has been found to be related to cognitive and other neuropsychological impairments,
whereas, its higher levels are associated with the tumour growth and metastasis and poor survival
rate in the cancer patients.

Conclusion:

In this review, we propose that variance in BDNF levels is critical in determining the
course of cellular pathophysiology and the development of cancer or neurodegenerative disorder. We
further propose that an alternative therapeutic strategy that can modulate BDNF expression, can rescue
or prevent above said pathophysiological course. Larger studies that examine this link through animal
studies are imperative to understand the putative biochemical and molecular link to wellness and disease.
The Growing Epidemic of Diabetes Mellitus
Authors: Lovic Dragan , Piperidou Alexia , Zografou Ioanna , Grassos Haralambos , Pittaras Andreas , Manolis Athanasios
Published: April 2019

Background:

During the past decades, the prevalence of diabetes (DM) has increased significantly,
mainly as a result of continuous rise in the incidence of type 2 DM. According to World Health
Organization statistics, >422 million adults globally were suffering from DM in 2014 and a continuous
rise in DM prevalence is expected.

Objective:

The present review considers recent epidemiological data providing worldwide estimates
regarding the incidence of DM.

Methods:

A comprehensive literature search was conducted to identify available data from epidemiological
studies evaluating the current burden of DM.

Results:

Over the past few decades the prevalence of DM has risen significantly in nearly all countries
and may be considered as a growing epidemic. Urbanization and income status are major factors which
influence current rates in the prevalence studies introducing interesting differences between several
population groups.

Conclusion:

Having recognized the global burden of DM, we now realize the urgent need for effective
interventions. In order to monitor the public-health strategies and design effective future interventions
we need reliable global estimates regarding the prevalence of DM.
Calcium and Vitamin D Supplementation. Myths and Realities with Regard to Cardiovascular Risk
Authors: Muscogiuri Giovanna , Barrea Luigi , Altieri Barbara , Di Somma Carolina , Bhattoa Harjit pal , Laudisio Daniela , Duval Guillaume T. , Pugliese Gabriella , Annweiler Cédric , Orio Francesco , Fakhouri Hana , Savastano Silvia , Colao Annamaria
Published: April 2019

Vitamin D and calcium are considered crucial for the treatment of bone diseases. Both vitamin D and calcium contribute to bone homeostasis but also preserve muscle health by reducing the risk of falls and fractures. Low vitamin D concentrations result in secondary hyperparathyroidism and contribute to bone loss, although the development of secondary hyperparathyroidism varies, even in patients with severe vitamin D deficiency. Findings from observational studies have shown controversial results regarding the association between bone mineral density and vitamin D/calcium status, thus sparking a debate regarding optimum concentrations of 25-hydroxyvitamin D and calcium for the best possible skeletal health. Although most of the intervention studies reported a positive effect of supplementation with calcium and vitamin D on bone in patients with osteoporosis, this therapeutic approach has been a matter of debate regarding potential side effects on the cardiovascular (CV) system. Thus, the aim of this review is to consider the current evidence on the physiological role of vitamin D and calcium on bone and muscle health. Moreover, we provide an overview on observational and interventional studies that investigate the effect of vitamin D and calcium supplementation on bone health, also taking into account the possible CV side-effects. We also provide molecular insights on the effect of calcium plus vitamin D on the CV system.
Clinical and Molecular Perspectives of Monogenic Hypertension
Authors: Levanovich Peter E. , Diaczok Alexander , Rossi Noreen F.
Published: April 2019

Advances in molecular research techniques have enabled a new frontier in discerning the
mechanisms responsible for monogenic diseases. In this review, we discuss the current research on
the molecular pathways governing blood pressure disorders with a Mendelian inheritance pattern,
each presenting with a unique pathophysiology. Glucocorticoid Remediable Aldosteronism (GRA)
and Apparent Mineralocorticoid Excess (AME) are caused by mutations in regulatory enzymes that
induce increased production of mineralocorticoids or inhibit degradation of glucocorticoids, respectively.
Geller syndrome is due to a point mutation in the hormone responsive element of the promotor
for the mineralocorticoid receptor, rendering the receptor susceptible to activation by progesterone,
leading to hypertension during pregnancy. Pseudohypoaldosteronism type II (PHA-II), also
known as Gordon’s syndrome or familial hyperkalemic hypertension, is a more variable disorder
typically characterized by hypertension, high plasma potassium and metabolic acidosis. Mutations
in a variety of intracellular enzymes that lead to enhanced sodium reabsorption have been identified.
In contrast, hypertension in Liddle’s syndrome, which results from mutations in the Epithelial
sodium Channel (ENaC), is associated with low plasma potassium and metabolic alkalosis. In Liddle’s
syndrome, truncation of one the ENaC protein subunits removes a binding site necessary protein
for ubiquitination and degradation, thereby promoting accumulation along the apical membrane
and enhanced sodium reabsorption. The myriad effects due to mutation in phosphodiesterase 3A
(PDE3A) lead to severe hypertension underlying sodium-independent autosomal dominant hypertension
with brachydactyly. How mutations in PDE3A result in the phenotypic features of this disorder
are discussed. Understanding the pathologies of these monogenic hypertensive disorders may
provide insight into the causes of the more prevalent essential hypertension and new avenues to
unravel the complexities of blood pressure regulation.
Synthesis and Cytotoxicity Evaluation of Novel Indole Derivatives as Potential Anti-Cancer Agents
Authors: Kamel Mona M. , Abdel-hameid Mohamed K. , El-Nassan Hala B. , El-Khouly Eman A.
Published: April 2019

Background:

Marine sponges and tunicates have been a wealthy source of cytotoxic
compounds such as indole alkaloids. Most of the indole alkaloids show in vitro cytotoxic and antineoplastic
activities against a wide range of cancer cell lines.

Objective:

Three series of bioisosteres of marine indole alkaloids (meridianins) were synthesized
and the compounds were tested for their in vitro anti-proliferative activity against HCT-116 cellline.
In the design of the targeted analogues, the 2-aminopyrimidine ring of merdianins was replaced
with 5-aminopyrazole, pyrazolo[1,5-a]pyrimidine and pyrazolo[3,4-b]pyridine rings.

Results:

The cytotoxic screening of the synthesized compounds revealed that pyrazolo[1,5-
a]pyrimidines (compounds 9c and 11a) had the most potent cytotoxic activity with IC50 = 0.31 μM
and 0.34 μM respectively. Compounds 9c and 11a were further investigated for their kinase inhibitory
potencies toward six kinases (CDK5/p25, CK1ð/ε, GSK-3α/β, Dyrk1A, Erk2, and CLK1).
They exhibited effective inhibition of GSK-3α/β (IC50 = 0.196 μM and 0.246 μM, respectively)
and Erk2 (IC50 = 0.295 μM and 0.376 μM, respectively).

Conclusion:

Meridianins emerged as promising lead structures that need further development to
obtain more selective and potent cytotoxic agents. One of these modifications involved the replacement
of 2-aminopyrimidinyl ring of meridianins with other heterocyclic rings. Both pyrazolo[
1,5-a]pyrimidine and pyrazolo[3,4-b]pyridine rings showed promising cytotoxic activity
compared to the five membered 5-aminopyrazole.
Synthesis of Tetrahydrobenzo[b]thiophene-3-carbohydrazide Derivatives as Potential Anti-cancer Agents and Pim-1 Kinase Inhibitors
Authors: Mohareb Rafat M. , Wardakhan Wagnat W. , Abbas Nermeen S.
Published: April 2019

Background:

Tetrahydrobenzo[b]thiophene derivatives are well known to be biologically active
compounds and many of them occupy a wide range of anticancer agent drugs.

Objective:

One of the main aim of this work was to synthesize target molecules not only possessing anti-tumor
activities but also kinase inhibitors. To achieve this goal, our strategy was to synthesize a series of 4,5,6,7-
tetrahydrobenzo[b]thiophene-3-carbohydrazide derivatives using cyclohexan-1,4-dione and cyanoacetylhydrazine
to give the 2-amino-6-oxo-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbohydrazide (3) as the key starting
material for many heterocyclization reactions.

Methods:

Compound 3 was reacted with some aryldiazonium salts and the products were cyclised when reacted
with either malononitrile or ethyl cyanoacetate. Thiazole derivatives were also obtained through the reaction of
compound 3 with phenylisothiocyanate followed by heterocyclization with α-halocarbonyl derivatives. Pyrazole,
triazole and pyran derivatives were also obtained.

Results:

The compounds obtained in this work were evaluated for their in-vitro cytotoxic activity against c-Met
kinase, and the six typical cancer cell lines (A549, H460, HT-29, MKN-45, U87MG, and SMMC-7721). The
results of anti-proliferative evaluations and c-Met kinase, Pim-1 kinse inhibitions revealed that some compounds
showed high activities.

Conclusion:

The most promising compounds 5b, 5c, 7c, 7d, 11b, 14a, 16b, 18b, 19, 21a, 23c, 23d and 23i
against c-Met kinase were further investigated against the five tyrosin kinases (c-Kit, Flt-3, VEGFR-2, EGFR,
and PDGFR). Compounds 5b, 5c, 7d, 7e, 11b, 11c, 16c, 16d, 18c, 19, 23e, 23k and 23m were selected to examine
their Pim-1 kinase inhibitions activity where compounds 7d, 7e, 11b, 11c, 16d, 18c and 23e showed high
activities. All of the synthesized compounds have no impaired effect toward the VERO normal cell line.
Analgesic and Anti-inflammatory Effects of Caryocar brasiliense
Authors: Junior Armando Jorge , Leitão Maicon Matos , Bernal Laura Priscila Toledo , dos Santos Elisângela , Kuraoka-Oliveira Ângela Midori , Justi Priscila , Argandoña Eliana Janet Sanjinez , Kassuya Cândida Aparecida Leite
Published: April 2019

Background:

Caryocar brasiliense, popularly known as pequi, is widely distributed
in the Amazon rainforest and Brazilian savannah. The fruit obtained from pequi is
used in cooking and has folk use as an anti-inflammatory and for the treatment of respiratory
disease. Until now, these two properties had not been scientifically demonstrated for
Pequi oil in a carrageenan model.

Objective:

Our group determined the composition and safe use of Pequi oil from the Savannah
of Campo Grande, and the anti-inflammatory and anti-nociceptive activities of this
pequi oil were investigated in vivo models.

Materials and Methods:

Doses of 300, 700, and 1000 mg/kg of Pequi oil were administered
orally (p.o.) to Swiss male mice, and three parameters of inflammation (mechanical
hyperalgesia, cold, hyperalgesia, and oedema) were analyzed in a carrageenan model to induce
an inflammatory paw state.

Results and Discussion:

The effects of Pequi oil were also carrageenan in pleurisy model,
formalin, and acetic acid induced nociception. Oral administration of 1,000 mg/kg orally
Pequi oil (p.o.) inhibited (*P<0.05), the migration of total leukocytes, but not alter plasma
extravasation, in the pleurisy model when compared to control groups. The paw edema
was inhibited with doses of 700 (P <0.05) and 1,000 mg (P<0.001) of pequi oil after 1, 2,
and 4 hours after carrageenan. Pequi oil (1,000 mg/kg) also blocked the mechanical hyperalgesy
and reduced cold allodynia induced by carrageenan in paw (P <0.05). Pequi oil
treatment (1,000 mg/kg) almost blocked (P < 0.001) all parameters of nociception observed
in formalin and acid acetic test.

Conclusion:

This is the first time that the analgesic and anti-inflammatory effects of Pequi
oil have been shown.
Emblica officinalis (Amla) Ameliorates High-Fat Diet Induced Alteration of Cardiovascular Pathophysiology
Authors: Patil Bheemshetty S. , Kanthe Pallavi S. , Reddy Chandramouli R. , Das Kusal K.
Published: April 2019

Background:

Dietary high fat possibly causes oxidative stress. Also, it alters the pathophysiology
of metabolically active myocardial tissues and vascular architecture. Emblica officinalis
contains a potential antioxidant that counteracts oxidative stress and possibly maintains vascular integrity.

Objective:

To assess the effect of ethanolic extract of Emblica officinalis (EEO) on High Fat Diet
(HFD) induced changes in vascular chemistry and histopathology of the cardiovascular system in
male albino rats.

Materials and Methods:

Ethanolic extract of Emblica Officinalis (EEO) was prepared and phytochemical
analysis was done. Rats were divided into four groups, having six rats in each group as follows:
group 1- Control (20% fat); group 2 (20% fat+ EEO 100 mg/kg/b w); group 3 (30% fat) and
group 4 (30% fat + EEO 100 mg/kg/b w). Dietary and EEO supplementation was continued for 21
days. Gravimetric and oxidative stress markers like MDA, NO, antioxidants like Vitamin C and E,
and molecular marker (NOS3) were evaluated. Histopathological analysis was done on the myocardium
and elastic artery along with measurement of coronary arterial wall thickness and lumen diameter.
One way ANOVA was done for analysis of data.

Results:

High fat diet showed a significant increase in MDA, decrease of NO with unaltered NOS3
protein in rats fed with high fat diet, which indicate possible alteration of vascular pathophysiology.
Supplementation of EEO showed an ameliorating effect on high fat diet induced oxidative stress.
These results were further corroborated with findings of a histopathological study on the myocardium,
elastic artery and coronary arterial architecture.

Conclusion:

Ethanolic extract of Emblica officinalis (EEO) indicates its cardioprotective efficacy
against rats fed with high fat diet.
Amyloid Oligomer Structures and Toxicity
Authors: G. Glabe Charles
Published: April 2019

Amyloid accumulation is commonly associated with a number of important human degenerative diseases and
recent findings indicate that soluble amyloid oligomers may represent the primary pathological species in degenerative
diseases. Amyloid oligomers are structurally and morphologically diverse, raising the question on whether this diversity is
pathologically significant and whether different types of oligomers may have different toxic activities. Many of the
amyloids associated with neurodegenerative diseases form three immunologically distinct types of oligomers. Fibrillar
oligomers are structurally related to fibrils and may represent small pieces of fibrils or fibril protofilaments. Prefibrillar
oligomers are kinetic intermediates in fibril formation and annular protofibrils that resemble membrane pores. These three
classes of oligomers share common structures and toxic activities. Focus on these common mechanisms of toxicity
provides a means of simplifying the list of primary disease mechanisms and opens the possibility of developing broad
spectrum therapeutics that target several amyloid related degenerative diseases.
Protein Misfolding Diseases
Authors: Bellotti Vittorio , Stoppini Monica
Published: April 2019

Diseases caused by protein misfolding are an emerging pathologic category that are thought to share some
basic common mechanisms and display impressive heterogeneity in terms of tissue involvement, age of onset and clinical
features. The growing recognition of the impact that protein misfolding has on human diseases is certainly related to the
phenomenon of population aging and the expansion of the population in which these diseases are more frequent, but it is
also based on a scientific revolution that looks at protein dynamics and relates these data to their potential pathologic
implications. The multidisciplinary exchange of knowledge between experts in apparently unrelated diseases, such as
sickle cell anemia and Alzheimer’s disease, has helped clarify the pathogenesis of these and many other diseases. The
quick expansion of knowledge on the mechanisms of these diseases is priming pharmaceutical research that is now
providing the first prototype drugs.
Membrane Systems for the Fight against Water-Borne Contaminants in Small Communities and Remote Areas from the Developing World:
Accomplishments in Thailand and Some New Development in Sénégal and Mali
Authors: Farcy Michel , Doucouré Abdoulaye
Published: April 2019

Pressure-driven membrane processes such as microfiltration (MF), ultrafiltration (UF), nanofiltration (NF) and
reverse osmosis (RO) are increasingly used to produce clean water for a broad range of domestic and industrial
applications. This article outlines some key features of these membrane-based technologies and describes how they can be
adapted to supply safe drinking water in remote communities and rural regions from the developing world. Three case
studies are reported in Asia (Thailand) and Africa (Sénégal and Mali) where we investigate the feasibility of removing
microorganisms and some dissolved pollutants from water with commercial pressure-driven filtration pilots. The convincing
success of the Thailand study established that Pall transportable MF/UF units could help local residents meet their
demand in high quality water. This case study provided some rationale for testing a similar concept in West Africa. Given
the technological efficacy, robustness and modularity of these membrane systems, we see them as innovative tools for
implementing a cost-effective and sustainable strategy to stop the emergence of water borne and vector borne infectious
diseases not only in the developing world but also in regions severely affected by natural disasters.
An Adaptive Fault-Tolerant and Congestion Controlled Selection Strategy for Networks on Chip
Authors: Arora Ashima , Shukla Neeraj K. , Kikan Shaloo
Published: April 2019

Background & Objective:

Networks on chip are being developed as a communication infrastructure
in the design of multiprocessor SOCs. With the reduction in feature size, transient faults
on the links are becoming a major issue on the performance of NOCs.

Methods:

In this paper, two fault-tolerant algorithms are proposed. In the first algorithm, a faulty link tolerant
algorithm is designed which by measuring network loads on the links will reduce transient faults and
balances the load. To address the effect of hardware faults, fault and congestion controlled algorithm is designed
that not only control the congestion, but also the faults on both links and the nodes.

Results:

The packet size is taken as 8 flits and data width of 32 bits are considered for all switches.
Input buffers are having 8 slots for storing data. The simulations are carried over two synthetic traffic
scenarios that are, hotspot and transpose.

Conclusion:

The proposed strategies are evaluated on two different synthetic traffic patterns and the
results so obtained shows better network and hardware performance of both the routing in comparison
with non-fault-tolerant routing.
Cooja Based Approach for Estimation and Enhancement of Lifetime of 6LoWPAN Environment
Authors: Garg Ruchi , Sharma Sanjay
Published: April 2019

Background and Objective:

The Scale with which Internet of Things (IoT) is penetrating
our day to day life, time is not far away when it would be the Internet of Everything (IoE) that will
require billions of devices to communicate with each other in the real world. To cater to the same,
Wireless Sensor Network (WSN) is composed of 6LoWPAN sensor-nodes, which are mainly battery
operated. One of the major issues, in such network, is nodes’ limited lifetime which is battery dependent.

Methods:

In this paper, we have suggested and implemented an approach for ‘Estimation and Enhancement
of Lifetime of Wireless Sensor Network’ (E&EL-WSN). The aim of our study is to suggest
an approach that helps in power saving of the batteries of sensor-nodes and will result in enhanced
life-time of 6LoWPAN environment. Our suggested approach is based on the concept of reduced
packet size resulting in saving of power consumption. Packet size is reduced by our Modified
and Improved Header Compression (MIHC) method of IPv6 header compression.

Results:

The simulation, done in Cooja, shows, in our case, an improvement of approximately 19%
saving of power consumption. This results in an enhancement of 70 days in the lifetime of the network,
which is almost 23% better than the existing approach.
Relationship Between Adherence to Remote Monitoring and Patient Characteristics: Observational Study in Women With Pregnancy-Induced Hypertension
Authors: Vandenberk Thijs , Lanssens Dorien , Storms Valerie , Thijs Inge M , Bamelis Lotte , Grieten Lars , Gyselaers Wilfried , Tang Eileen , Luyten Patrick
Published: April 2019

Background

Pregnancy-induced hypertension (PIH) is associated with high levels of morbidity and mortality in mothers, fetuses, and newborns. New technologies, such as remote monitoring (RM), were introduced in 2015 into the care of patients at risk of PIH in Ziekenhuis Oost-Limburg (Genk, Belgium) to improve both maternal and neonatal outcomes. In developing new strategies for obstetric care in pregnant women, including RM, it is important to understand the psychosocial characteristics associated with adherence to RM to optimize care.

Objective

The aim of this study was to explore the role of patients’ psychosocial characteristics (severity of depression or anxiety, cognitive factors, attachment styles, and personality traits) in their adherence to RM.

Methods

Questionnaires were sent by email to 108 mothers the day after they entered an RM program for pregnant women at risk of PIH. The Generalized Anxiety Disorder Assessment-7 and Patient Health Questionnaire-9 (PHQ-9) were used to assess anxiety and the severity of depression, respectively; an adaptation of the Pain Catastrophizing Scale was used to assess cognitive factors; and attachment and personality were measured with the Experiences in Close Relationships-Revised Scale (ECR-R), the Depressive Experiences Questionnaire, and the Multidimensional Perfectionism Scale, respectively.

Results

The moderate adherence group showed significantly higher levels of anxiety and depression, negative cognitions, and insecure attachment styles, especially compared with the over adherence group. The low adherence group scored significantly higher than the other groups on other-oriented perfectionism. There were no significant differences between the good and over adherence groups. Single linear regression showed that the answers on the PHQ-9 and ECR-R questionnaires were significantly related to the adherence rate.

Conclusions

This study demonstrates the relationships between adherence to RM and patient characteristics in women at risk of PIH. Alertness toward the group of women who show less than optimal adherence is essential. These findings call for further research on the management of PIH and the importance of individual tailoring of RM in this patient group.

Trial Registration

ClinicalTrials.gov NCT03509272; https://clinicaltrials.gov/ct2/show/NCT03509272
Implementation of a Novel Electronic Patient-Directed Smoking Cessation Platform for Cancer Patients: Interrupted Time Series Analysis (Preprint)
Authors: Giuliani Meredith Elana , Liu Geoffrey , Xu Wei , Dirlea Mihaela , Selby Peter , Papadakos Janet , Abdelmutti Nazek , Yang Dongyang , Eng Lawson , Goldstein David Paul , Jones Jennifer Michelle
Published: April 2019

BACKGROUND

Continued smoking in cancer patients undergoing treatment results in significantly higher rates of treatment toxicities and persistent effects, increased risk of recurrence and second malignancy, and increased all-cause mortality. Despite this, routine tobacco use screening and the provision of smoking cessation treatment has yet to be implemented widely in the cancer setting.

OBJECTIVE

The objective of this study was to implement and evaluate the adoption and impact of an innovative Smoking Cessation e-referral System (CEASE) to promote referrals to smoking cessation programs in cancer patients.

METHODS

A patient-directed electronic smoking cessation platform (CEASE) was developed to promote smoking screening and referral and implemented at 1 of Canada’s largest cancer centers. The implementation and evaluation were guided by the Ottawa Model of Research Use. An interrupted time series design was used to examine the impact of CEASE on screening rates, referrals offered, and referrals accepted compared with a previous paper-based screening program. A subsample of smokers or recent quitters was also assessed and compared pre- and postimplementation to examine the effect of CEASE on subsequent contact with smoking cessation programs and quit attempts.

RESULTS

A total of 17,842 new patients attended clinics over the 20-month study period. The CEASE platform was successfully implemented across all disease sites. Screening rates increased from 44.28% (2366/5343) using the paper-based approach to 65.72% (3538/5383) using CEASE (P<.01), and referrals offered to smokers who indicated interest in quitting increased from 18.6% (58/311) to 98.8% (421/426; P<.01). Accepted referrals decreased from 41% (24/58) to 20.4% (86/421), though the overall proportion of referrals generated from total current/recent tobacco users willing to quit increased from 5.8% (24/414) to 20.2% (86/426) due to the increase in referrals offered. At 1-month postscreening, there was no significant difference in the proportion that was currently using tobacco and had not changed use in the past 4 weeks (pre: 28.9% [24/83] and post: 28.8% [83/288]). However, contact with the referral program increased from 0% to 78% in the postCEASE cohort (P<.001).

CONCLUSIONS

CEASE is an innovative tool to improve smoking screening and can be implemented in both a time- and cost-effective manner which promotes sustainability. CEASE was successfully implemented across all clinics and resulted in improvements in overall screening and referral rates and engagement with referral services.
Documentación de la práctica: una experiencia con docentes de Educación Inicial
Authors: Villegas Margarita , Enrique González Fredy , Hernández Caamaño Mercedes
Published: April 2019

Este artículo surgió ante la poca disponibilidad de infor­mación sistemática sobre las prácticas pedagógicas que ocurren al interior del nivel inicial. Por ende, se reporta una investigación de carácter descriptivo-documental que tuvo como asunto de interés indagatorio las prácticas de aula, llevadas a cabo con infantes de cinco años de edad, ejecutadas por cuatro equipos de docentes participantes en una Especialidad en Educación Inicial, en República Dominicana. El corpus del estudio estuvo constituido por cuatro “cuadernillos”, donde dichos docentes expusieron los pormenores de sus prácticas, los cuales, fueron some­tidos a un análisis cualitativo de contenido. Esto permitió identificar algunos de sus saberes pedagógicos desarrolla­dos, además, inferir que la documentación de la práctica contribuye con la revalorización de la cotidianidad del ejercicio docente, puesto que al documentarla y, por ende, hacerla explícita, la práctica se convierte en un texto sus­ceptible de ser analizado, reflexionado y cuestionado, lo cual sirve de base para reestructurarla, por tanto, ejecutarla de una mejor manera durante acciones docentes futuras.
Reseña de la película “La Educación Prohibida”
Authors: Ortega Barrera Marino
Published: April 2019

No precisa de un resumen
Editorial
Authors: Escala Miguel J.
Published: April 2019

No precisa de un resumen.
Práticas sustentáveis de inovação para tomada de decisão baseada na percepção de gestores e associados: um estudo nas Associações Atléticas do Banco do Brasil
Authors: Silva Geraldo Luiz Oliveira , ALBERTON ANETE ALBERTON
Published: April 2019

Este estudo visa identificar e analisar as percepções de associados e dirigentes das Associações Atléticas Banco do Brasil (AABBs) no contexto nacional com base na sustentabilidade. O método de pesquisa Quantitativa com abordagem descritiva foi utilizado para analisar os questionários com perguntas semiestruturadas e fechadas aplicadas on line aos dirigentes e associados da amostra de 305 clubes no universo de 1.088, selecionados pelo critério de previsibilidade considerando aqueles que desenvolvem ou desenvolveram o Programa de Integração AABB Comunidade que tem como propósito, fornecer assistência complementar a escola para crianças e adolescentes de 6 a 18 anos incompletos nas dependências dos clubes, em horários inversos ao escolar, que vivem em comunidades carentes. A amostra representa 28% do total de AABBs distribuídas em todas as regiões e o estudo utilizou como base o conceito Triple Bottom Line. Os resultados apontaram que as práticas diárias e atividades coletivas dos clubes na dimensão ambiental são inexpressivas. Na dimensão social evidenciou-se a característica principal desses clubes como associações desportivas, de onde se percebe a integração esportiva como diferencial. Na análise econômica constatou-se a existência de credibilidade dos associados em relação às políticas financeiras internas, contudo, as poucas ações comunitárias apresentadas nas três dimensões, caracterizam esses clubes como entidades de pouca interação e participação da sociedade nos municípios onde estão inseridos.
Inteligência Emocional e Engajamento no Ambiente de Trabalho: Estudo Empírico a Partir de Gestores e Equipes
Authors: Hansen Rogério , Fabricio Adriane , Rotili Liane Beatriz , Lopes Luis Felipe Dias
Published: April 2019

O objetivo deste artigo é identificar possíveis relações entre as dimensões de inteligência emocional e dimensões de engajamento no trabalho em gestores e membros de equipes. Trata-se de uma pesquisa descritiva tipo survey, com abordagem qualitativa e quantitativa dos dados. Os participantes do estudo são 132 profissionais, que ocupam cargos de gestão ou são membros de equipes, que possuem atividade formal de trabalho remunerada, e atuam no estado do Rio Grande do Sul. Os instrumentos de pesquisa aplicados foram o Emotional Intelligence Appraisal ® (EIA), questionário elaborado por Travis Bradberry e Jean Greaves (2016) e o Utrecht Work Engagement Scale (UWES-17) elaborado por Schaufeli e Bakker (2003) e adaptado por Angst, Benevides-Pereira e Porto Martins (2009). Identificou-se que os profissionais gestores e membros de equipes possuem altos níveis de inteligência emocional (77,27%) e engajamento no trabalho (67,33%). Existe relação forte e positiva entre as dimensões de inteligência emocional e engajamento no trabalho (0,613), ou seja, quanto mais índices de inteligência emocional o profissional apresentar, maior será o seu engajamento em relação ao seu trabalho. As evidências contribuem para as decisões organizacionais que implicam nos objetivos das organizações.