bluuebunny/crossref_metadata_2025 huggingface dataset:
Cryo-EM structure of the human ferritin–transferrin receptor 1 complex
Authors: Montemiglio Linda Celeste , Testi Claudia , Ceci Pierpaolo , Falvo Elisabetta , Pitea Martina , Savino Carmelinda , Arcovito Alessandro , Peruzzi Giovanna , Baiocco Paola , Mancia Filippo , Boffi Alberto , des Georges Amédée , Vallone Beatrice
Published: March 2019

Human transferrin receptor 1 (CD71) guarantees iron supply by endocytosis upon binding of iron-loaded transferrin and ferritin. Arenaviruses and the malaria parasite exploit CD71 for cell invasion and epitopes on CD71 for interaction with transferrin and pathogenic hosts were identified. Here, we provide the molecular basis of the CD71 ectodomain-human ferritin interaction by determining the 3.9 Å resolution single-particle cryo-electron microscopy structure of their complex and by validating our structural findings in a cellular context. The contact surfaces between the heavy-chain ferritin and CD71 largely overlap with arenaviruses and Plasmodium vivax binding regions in the apical part of the receptor ectodomain. Our data account for transferrin-independent binding of ferritin to CD71 and suggest that select pathogens may have adapted to enter cells by mimicking the ferritin access gate.
CC chemokines are differentially expressed in Breast Cancer and are associated with disparity in overall survival
Authors: Thomas Jeronay K. , Mir Hina , Kapur Neeraj , Bae Sejong , Singh Shailesh
Published: March 2019

Despite recent advances, breast cancer (BrCa) still affects many women and the impact is disproportional in African Americans (AA) compared to European Americans (EA). Addressing socioeconomic and behavioral status has not been enough to reduce disparity, suggesting contribution of biological differences in BrCa disparity. Our laboratory was first to show involvement of CC chemokines in BrCa. In this study, using ONCOMINE, TCGA, bc-GenExMiner and KMplotter, we examined the association of CC chemokines in BrCa outcomes and disparity. We show over-expression of CCL5, -7, -11, -17, -20, -22 and -25 in BrCa tissues. High mRNA levels of CCL7, -8, -17, -20 and -25 predicted a decrease in overall survival (OS). CCL7 and CCL8 were associated with decreased relapse-free survival. Expression of CCL17 and CCL25 was associated with decreased OS in AA. In EA, CCL8 was associated with decreased OS. Expression of CCL5, -7, -8, -17, -20 and -25 was highest in TNBC. Expression of CCL11 and CCL22 was associated with HER2. CCL7, -8, -17, -20 and -25 were elevated in AAs. In conclusion, our analysis suggests significant association of CC-chemokines in BrCa progression, OS and disparate disease outcome in AA compared to EA patients.
Cumulative and different genetic effects contributed to yield heterosis using maternal and paternal backcross populations in Upland cotton
Authors: Ma Lingling , Wang Yumei , Ijaz Babar , Hua Jinping
Published: March 2019

Heterosis has been utilized in commercial production, but the heterosis mechanism has remained vague. Hybrid cotton is suitable to dissect the heterosis mechanism. In order to explore the genetic basis of heterosis in Upland cotton, we generated paternal and maternal backcross (BC/P and BC/M) populations. Data for yield and yield-component traits were collected over 2 years in three replicated BC/P field trials and four replicated BC/M field trials. At single-locus level, 26 and 27 QTLs were identified in BC/P and BC/M populations, respectively. Six QTLs shared in both BC populations. A total of 27 heterotic loci were detected. Partial dominant and over-dominant QTLs mainly determined yield heterosis in the BC/P and BC/M populations. QTLs for different traits displayed varied genetic effects in two BC populations. Eleven heterotic loci overlapped with QTLs but no common heterotic locus was detected in both BC populations. We resolved the 333 kb (48 genes) and 516 kb (25 genes) physical intervals based on 16 QTL clusters and 35 common QTLs, respectively, in more than one environment or population. We also identified 189 epistatic QTLs and a number of QTL × environment interactions in two BC populations and the corresponding MPH datasets. The results indicated that cumulative effects contributed to yield heterosis in Upland cotton, including epistasis, QTL × environment interaction, additive, partial dominance and over-dominance.
Analgesia after major laparoscopic surgery in patients with chronic kidney disease: A retrospective cohort study
Authors: Choi Hey-ran , Oh Tak Kyu , Kim Jinhee , Jeon Young-Tae
Published: March 2019

The amount of reduction in opioid doses and its effect on postoperative pain outcomes in chronic kidney disease (CKD) patients in the perioperative setting remains unclear. This study aimed to investigate differences in postoperative pain outcomes after major laparoscopic surgery between patients with CKD and those with normal preoperative kidney function. Medical records of patients who underwent laparoscopic major abdominal surgery from January 2010 to December 2016 were retrospectively reviewed, and 6,612 patients were finally included. During postoperative day (POD) 0–3, patients with an estimated glomerular filtration rate (eGFR) < 30 mL min−1 1.73 m−2 had 3.5% lower morphine equivalent consumption than those with an eGFR ≥ 90 mL min−1 1.73 m−2 (P = 0.023), whereas patients with preoperative eGFR between 60–90 mL min−1 1.73 m−2 and 30–60 mL min−1 1.73 m−2 showed no significant differences in morphine equivalent consumption. Additionally, pain scores at rest during POD 0–3 were not significantly associated with preoperative kidney function. In conclusion, our results suggest that patients with mild to moderate CKD (stage 2–3) did not require reduction of opioid analgesics during POD 0–3, compared to patients with normal preoperative kidney function. Only patients with severe CKD (stage ≥ 4) might require a slight reduction of opioid analgesics.
Development of an efficient cytosolic isobutanol production pathway in Saccharomyces cerevisiae by optimizing copy numbers and expression of the pathway genes based on the toxic effect of α-acetolactate
Authors: Park Seong-Hee , Hahn Ji-Sook
Published: March 2019

Isobutanol production in Saccharomyces cerevisiae is limited by subcellular compartmentalization of the pathway enzymes. In this study, we improved isobutanol production in S. cerevisiae by constructing an artificial cytosolic isobutanol biosynthetic pathway consisting of AlsS, α-acetolactate synthase from Bacillus subtilis, and two endogenous mitochondrial enzymes, ketol-acid reductoisomerase (Ilv5) and dihydroxy-acid dehydratase (Ilv3), targeted to the cytosol. B. subtilis AlsS was more active than Ilv2ΔN54, an endogenous α-acetolactate synthase targeted to the cytosol. However, overexpression of alsS led to a growth inhibition, which was alleviated by overexpressing ILV5ΔN48 and ILV3ΔN19, encoding the downstream enzymes targeted to the cytosol. Therefore, accumulation of the intermediate α-acetolactate might be toxic to the cells. Based on these findings, we improved isobutanol production by expressing alsS under the control of a copper-inducible CUP1 promoter, and by increasing translational efficiency of the ILV5ΔN48 and ILV3ΔN19 genes by adding Kozak sequence. Furthermore, strains with multi-copy integration of alsS into the delta-sequences were screened based on growth inhibition upon copper-dependent induction of alsS. Next, the ILV5ΔN48 and ILV3ΔN19 genes were integrated into the rDNA sites of the alsS-integrated strain, and the strains with multi-copy integration were screened based on the growth recovery. After optimizing the induction conditions of alsS, the final engineered strain JHY43D24 produced 263.2 mg/L isobutanol, exhibiting about 3.3-fold increase in production compared to a control strain constitutively expressing ILV2ΔN54, ILV5ΔN48, and ILV3ΔN19 on plasmids.
Development of an SNP-based high-density linkage map and QTL analysis for bruchid (Callosobruchus maculatus F.) resistance in black gram (Vigna mungo (L.) Hepper)
Authors: Somta Prakit , Chen Jingbin , Yundaeng Chutintorn , Yuan Xingxing , Yimram Tarika , Tomooka Norihiko , Chen Xin
Published: March 2019

Black gram (Vigna mungo var. mungo) is an important pulse crop in Asia. The cowpea weevil (Callosobruchus maculatus) is a stored-seed insect pest (seed weevil/bruchid) that causes serious postharvest losses in pulse crops, including black gram. In this study, we constructed a high-density linkage map for black gram and identified quantitative trait loci (QTLs) for C. maculatus resistance. A recombinant inbred line (RIL) population of 150 lines from a cross between BC48 [cultivated black gram (var. mungo); bruchid-susceptible] and TC2210 [wild black gram (var. silvestris); bruchid-resistant] were used to construct a linkage map of 3,675 SNP markers from specific-locus amplified fragment sequencing. The map comprised 11 linkage groups spanning 1,588.7 cM with an average distance between adjacent markers of 0.57 cM. Seeds of the RIL population grown in 2016 and 2017 were evaluated for C. maculatus resistance through two traits; the percentage of damaged seeds (PDS) and infestation severity progress (AUDPS). Inclusive composite interval mapping identified three QTLs each for PDS and AUDPS. Two QTLs, qVmunBr6.1 and qVmunBr6.2, mapped about 10 cM apart on linkage group 6 were common between PDS and AUDPS. Comparative genome analysis revealed that qVmunBr6.1 and qVmunBr6.2 are new loci for C. maculatus resistance in Vigna species and that genes encoding a lectin receptor kinase and chitinase are candidates for qVmunBr6.2. The high-density linkage map constructed and QTLs for bruchid resistance identified in this study will be useful for molecular breeding of black gram.
Charge Storage by Electrochemical Reaction of Water Bilayers Absorbed on MoS2 Monolayers
Authors: Zhou Ruihua , Wei Sufeng , Liu Yan , Gao Nan , Wang Guoyong , Lian Jianshe , Jiang Qing
Published: March 2019

It is well-known that in neutral and acidic aqueous electrolytes, MoS2 monolayers can store charges by adsorption of cations on to the electrode-electrolyte interface as its analog of graphene. Restricted by its low conductivity and the charge storage mechanism, the electrochemical performance of MoS2 monolayer supercapacitor electrode is not satisfactory. It is reported here that water bilayers absorbed on MoS2 monolayers can be involved in charge storage. One proton of each absorbed water molecule can intercalate/de-intercalate the water bilayers during charging/discharging in the alkaline aqueous electrolyte. For two water molecules are present for every Mo atom, the water bilayers can endow MoS2 monolayers an ultrahigh specific capacitance. In this paper, 1T phase MoS2 nanosheets with three monolayers were synthesized by hydrothermal reaction. It presents a specific capacitance of 1120 F g−1 at a current density of 0.5 A g−1 in KOH. As it is assembled with active carbon into a hybrid supercapacitor, the device has an energy density of 31.64 Wh kg−1 at a power density of 425 W kg−1, and gets a specific capacitance retention of 95.4% after 10,000 cycles at 2 A g−1.
Reconstruction of noisy images via stochastic resonance in nematic liquid crystals
Authors: Feng Xingpan , Liu Hongjun , Huang Nan , Wang Zhaolu , Zhang Yongbin
Published: March 2019

We employ nematic liquid crystals as the nonlinear medium to recover noisy images via stochastic resonance, in which nonlinear coupling allows signals to grow at the expense of noise. The process is theoretically analyzed and the cross-correlation is numerically calculated. It is found that the quality of output images is affected by the input noise intensity, the applied voltage and the correlation length of noise light. Noise-hidden images can be effectively recovered by optimizing these parameters. The results suggest that nematic liquid crystals can be used for reconstruction of noisy images via stochastic resonance based on modulation instability with molecule reorientation nonlinearity.
Large intravalley scattering due to pseudo-magnetic fields in crumpled graphene
Authors: Kun Péter , Kukucska Gergő , Dobrik Gergely , Koltai János , Kürti Jenő , Biró László Péter , Tapasztó Levente , Nemes-Incze Péter
Published: March 2019

The pseudo-magnetic field generated by mechanical strain in graphene can have dramatic consequences on the behavior of electrons and holes. Here we show that pseudo-magnetic field fluctuations present in crumpled graphene can induce significant intravalley scattering of charge carriers. We detect this by measuring the confocal Raman spectra of crumpled areas, where we observe an increase of the D′/D peak intensity ratio by up to a factor of 300. We reproduce our observations by numerical calculation of the double resonant Raman spectra and interpret the results as experimental evidence of the phase shift suffered by Dirac charge carriers in the presence of a pseudo-magnetic field. This lifts the restriction on complete intravalley backscattering of Dirac fermions.
An artificially engineered “tumor bio-magnet” for collecting blood-circulating nanoparticles and magnetic hyperthermia
Authors: Liang Bing , Yu Kexiao , Ling Yi , Kolios Micheal , Exner Agata , Wang Zhigang , Hu Bing , Zuo Guoqing , Chen Yu , Zheng Yuanyi
Published: March 2019

We report a novel approach to transform a tumor into a “bio-magnet”, to be magnetized on demand, in order to create an intrinsic tumor magnetic field, able to collect magnetic nanoparticles circulating in the blood and achieve simultaneous magnetic hyperthermia.
Transition-metal solvated-electron precursors: diffuse and 3d electrons in V(NH3)0,±6
Authors: Almeida Nuno M. S. , Pawłowski Filip , Ortiz Joseph Vincent , Miliordos Evangelos
Published: March 2019

Ground and excited electronic states of V(NH3)0,±6 complexes, investigated with ab initio electronic structure theory, consist of a V(NH3)62+ core with up to three electrons distributed over its periphery.
Strain-induced indirect-to-direct bandgap transition in an np-type LaAlO3/SrTiO3(110) superlattice
Authors: Wang L. , Pan W. , Hu W. X. , Sun D. Y.
Published: March 2019

By applying uniaxial in-plane strains, an indirect-to-direct bandgap transition occurs in the polar LaAlO3/SrTiO3 (110) superlattices.
Synergy between dihydromyricetin intervention and irinotecan chemotherapy delays the progression of colon cancer in mouse models
Authors: Zhu Xiao-Hui , Lang He-Dong , Wang Xiao-Lan , Hui Suo-Cheng , Zhou Min , Kang Chao , Yi Long , Mi Man-Tian , Zhang Yong
Published: March 2019

Dihydromyricetin may be a favorable chemotherapeutic coadjuvant agent to reduce colonic tumorsviadifferent mechanisms in two mouse models.
Microfluidic device for expedited tumor growth towards drug evaluation
Authors: Uhl Christopher George , Liu Yaling
Published: March 2019

Expedited cancer growth technique to generate cancer populations for therapeutic screening within 3 days utilizing media flow and few cells.
Organotin compound DBDCT induces CYP3A suppression through NF-κB-mediated repression of PXR activity
Authors: Li Yunlan , Lin Niu , Ji Xiaoqing , Mai Jiaqi , Li Qingshan
Published: March 2019

Organotin anticancer agent di-n-butyl-di-(4-chlorobenzohydroxamato)tin(iv) (DBDCT) exerted an inhibitory effect on its major metabolic enzyme cytochrome CYP3A. But whether hepatic drug-metabolizing enzymes and their regulatory nuclear receptors including pregnane PXR and constitutive androstane CAR binding with retinoid receptor RXR as a heterodimer are involved in the DBDCT-mediated regulation of CYP3A remains unclear. This study was undertaken to determine the mechanisms responsible for the effects of DBDCT on CYP3A suppression, focusing on the PXR-mediated and NF-κB pathways. The results indicated DBDCT suppressed CYP3A expression by inhibiting CAR expression. But what's interesting is, both protein and mRNA of PXR increased with increasing DBDCT. A further exploration, dual luciferase reporter gene analysis, clarified that DBDCT induced CYP3A expression elevation via the PXR-mediated pathway and this induction was countered by activation of NF-κB, which played a pivotal role in suppression of CYP3A through disrupting the association of the PXR–RXRα complex with DNA sequences by EMSA. PXR-mediated CYP3A expression was similarly demonstrated by RNAi. As expected, expression of CYP3A and its mRNA levels were reduced by DBDCT only in NF-κB(+/+) but not in NF-κB(−/−) cells. The inductive effect of DBDCT on CYP3A4 mRNA was enhanced in PXR shRNA-transfected cells but weakened in the ip65 group, which showed both PXR up-regulated CYP3A expression and NF-κB p65 activation directly contributed to CYP3A inhibition. In conclusion, activated NF-κB by DBDCT interacts directly with the DNA-binding domain of PXR, and disrupts the binding between the PXR–RXR dimer, thereby affecting the regulatory process for CYP3A transcription and, therefore, leading to a decrease of the expression of the PXR-regulated CYP3A.
Fragment-centric topographic mapping method guides the understanding of ABCG2-inhibitor interactions
Authors: Wu Yao , Gao Xin-Ying , Chen Xin-Hui , Zhang Shao-Long , Wang Wen-Juan , Sheng Xie-Huang , Chen De-Zhan
Published: March 2019

Our study gains insight into the development of novel specific ABCG2 inhibitors, and develops a comprehensive computational strategy to understand protein ligand interaction with the help of AlphaSpace, a fragment-centric topographic mapping tool.
De novo synthesis of mesoporous photoactive titanium(iv)–organic frameworks with MIL-100 topology
Authors: Castells-Gil Javier , M. Padial Natalia , Almora-Barrios Neyvis , da Silva Ivan , Mateo Diego , Albero Josep , García Hermenegildo , Martí-Gastaldo Carlos
Published: March 2019

The development of new titanium frameworks remains limited by the difficulties in forming persistent Ti clusters amenable to the isoreticular approach. MIL-100(Ti) combines a mesoporous structure with excellent chemical stability and photoactivity from the reticulation of Ti3(μ3-O) metal-oxo clusters.
Soft-nanocomposite lubricants of supramolecular gel with carbon nanotubes
Authors: Bai Yanyan , Yu Qiangliang , Zhang Jiaying , Cai Meirong , Liang Yongmin , Zhou Feng , Liu Weimin
Published: March 2019

The soft-nanocomposite lubricants have excellent lubricity and anti-wear properties due to the synergistic effect of the effective adsorption film formed by the gelator and the rolling of the carbon nanotubes at the friction interface.
ZnO quantum dots anchored in multilayered and flexible amorphous carbon sheets for high performance and stable lithium ion batteries
Authors: Fernando Joseph F. S. , Zhang Chao , Firestein Konstantin L. , Nerkar Jawahar Y. , Golberg Dmitri V.
Published: March 2019

The role of the carbonaceous component in the excellent (de)lithiation properties of a ZnO/carbon anode material, as revealed by in situ TEM.
Increased charge carrier mobility and molecular packing of a solution sheared diketopyrrolopyrrole-based donor–acceptor copolymer by alkyl side chain modification
Authors: Hambsch Mike , Erdmann Tim , Chew Annabel R. , Bernstorff Sigrid , Salleo Alberto , Kiriy Anton , Voit Brigitte , Mannsfeld Stefan C. B.
Published: March 2019

Side chain extension leads to improved charge carrier mobility in diketopyrrolopyrrole-based donor–acceptor copolymers.
Positively charged helical chain-modified stimuli-responsive nanoassembly capable of targeted drug delivery and photoacoustic imaging-guided chemo-photothermal synergistic therapy
Authors: Zhang Jian , Qiao Zhu , Liu Huan-Ying , Song Jibin , Yin Jun
Published: March 2019

Tumor targeted size-switchable CPT/IR780@H30-PCL-PPI(L−)/PEI(–COOH/FA) nanoassembly with a “pomegranate” construction was designed, which could efficiently expand the penetration depth and accelerate the cell internalization.
Influence of the physicochemical characteristics of diatom frustules on hemorrhage control
Authors: Wang Lulu , Pan Kehou , Li Jing , Li Yun , Zhu Baohua , Wang Yanan , Feng Chao , Han Jichang
Published: March 2019

Diatom frustules are good resources for hemostasis agent production.
A self-assembly and higher order structure forming triple helical protein as a novel biomaterial for cell proliferation
Authors: Ilamaran Meganathan , Janeena Asuma , Valappil Sisila , Ramudu Kamini Numbi , Shanmugam Ganesh , Niraikulam Ayyadurai
Published: March 2019

Collagen plays a critical role in the structural design of the extracellular matrix (ECM) and cell signaling in mammals, which makes it one of the most promising biomaterials with versatile applications.
Isomerizations of a Pt4 cluster revealed by spatiotemporal microscopic analysis
Authors: Imaoka Takane , Toyonaga Tetsuya , Morita Mari , Haruta Naoki , Yamamoto Kimihisa
Published: March 2019

We now report the first direct observation of the fluxional nature in which the four-atomic platinum cluster (Pt4) randomly walks through several isomers.
A far-red fluorescent probe for sensing laccase in fungi and its application in developing an effective biocatalyst for the biosynthesis of antituberculous dicoumarin
Authors: Tian Zhenhao , Yan Qingsong , Feng Lei , Deng Sa , Wang Chao , Cui Jingnan , Wang Chunjie , Zhang Zhanjun , James Tony D. , Ma Xiaochi
Published: March 2019

A far-red fluorescent probe for sensing laccase in fungi and its application in developing an effective biocatalyst for the biosynthesis of antituberculous dicoumarin.
Cyclizations catalyzed inside a hexameric resorcinarene capsule
Authors: Zhu Yujie , Rebek Jr Julius , Yu Yang
Published: March 2019

The self-assembled, hydrogen-bonded hexameric resorcin[4]arene capsule represents one of the most readily accessible host systems for the study of container catalysis.
Identification of the Criegee intermediate reaction network in ethylene ozonolysis: impact on energy conversion strategies and atmospheric chemistry
Authors: Rousso Aric C. , Hansen Nils , Jasper Ahren W. , Ju Yiguang
Published: March 2019

The reaction network of the simplest Criegee intermediate (CI) CH2OO has been studied experimentally during the ozonolysis of ethylene.
Quantum state control on the chemical reactivity of a transition metal vanadium cation in carbon dioxide activation
Authors: Chang Yih Chung , Xu Yuntao , Ng Cheuk-Yiu
Published: March 2019

By utilizing a newly developed spin-orbit electronic state selected ion source for atomic transition metal vanadium cation (V+), the chemical reactivity of V+ with CO2 has been examined in detail, indicating that the titled reaction is dominantly governed by electron spin conservation, and thus the chemical reactivity can be controlled by quantum electronic state selections.
Melting of nucleobases. Getting the cutting edge of “Walden's Rule”
Authors: Abdelaziz A. , Zaitsau D. H. , Kuratieva N. V. , Verevkin S. P. , Schick C.
Published: March 2019

Surprisingly high melting temperatures of the five nucleobases have been measured using a specially developed fast scanning calorimetry method that prevents decomposition. Results are rationalized in terms of an “ideal associated solution”.
Materials chemistry in flexible electronics
Authors: Chen Xiaodong , Rogers John A. , Lacour Stéphanie P. , Hu Wenping , Kim Dae-Hyeong
Published: March 2019

Guest editors Xiaodong Chen, John A. Rogers, Stéphanie P. Lacour, Wenping Hu, and Dae-Hyeong Kim introduce the Materials chemistry in flexible electronics themed issue of Chemical Society Reviews.
N-Methylation of ortho-substituted aromatic amines with methanol catalyzed by 2-arylbenzo[d]oxazole NHC–Ir(iii) complexes
Authors: Huang Shuang , Hong Xi , Cui He-Zhen , Zhou Quan , Lin Yue-Jian , Hou Xiu-Feng
Published: March 2019

By the modification on benzo[d]oxazolyl-NHC-ligated cyclometalated Ir complexes, the N-methylation of ortho-substituted aromatic amines with methanol was remarkably improved.
Mononuclear lanthanide complexes assembled from a tridentate NNO donor ligand: design of a DyIIIsingle-ion magnet
Authors: Kalita Pankaj , Malakar Amit , Goura Joydeb , Nayak Subhashree , Herrera Juan Manuel , Colacio Enrique , Chandrasekhar Vadapalli
Published: March 2019

A new family of mononuclear LnIIIcomplexes were synthesized by utilizing a tridentate Schiff base ligand. SIM behaviour is seen in the DyIIIanalogue (diluted) withUeff= 68(2) K under a 1000 Oe applied dc field.
Synthesis, characterization, and reactivity of dinuclear organo-rare-earth-metal alkyl complexes supported by 2-amidate-functionalized indolyl ligands: substituent effects on coordination and reactivity
Authors: Hong Dongjing , Zhu Xiancui , Wang Shaowu , Wei Yun , Zhou Shuangliu , Huang Zeming , Zhu Shan , Wang Ruru , Yue Wenrun , Mu Xiaolong
Published: March 2019

Different coordination modes and activities of the dinuclear complexes with the functionalized indolyl ligands were found.
Photothermal effect by NIR-responsive excretable ultrasmall-in-nano architectures
Authors: Cassano Domenico , Santi Melissa , D’Autilia Francesca , Mapanao Ana Katrina , Luin Stefano , Voliani Valerio
Published: March 2019

Here, we report: (i) the straightforward production of narrow-NIR-absorbing gold ultrasmall-in-nano architectures (tNAs), and (ii) their suitability as excretable platforms for photothermal therapy upon CW-irradiation at 808 nm. These findings are a significant step toward the translation of metal nanotheranostics to cancer treatments.
Poloxin-2HT+: changing the hydrophobic tag of Poloxin-2HT increases Plk1 degradation and apoptosis induction in tumor cells
Authors: Rubner Stefan , Schubert Sabine , Berg Thorsten
Published: March 2019

Hydrophobically-tagged Poloxin-2HT+ selectively degrades the tumor target Plk1 and induces apoptosis in tumor cells with higher potency than Poloxin-2HT.
Correlations between secondary structure- and protein–protein interface-mimicry: the interface mimicry hypothesis
Authors: Taechalertpaisarn Jaru , Lyu Rui-Liang , Arancillo Maritess , Lin Chen-Ming , Perez Lisa M. , Ioerger Thomas R. , Burgess Kevin
Published: March 2019

Preferred conformations of several peptidomimetics (specifically, minimalist mimics) were elucidated and compared with protein-protein interfaces on a huge scale, leading to a hypothesis regarding how these compounds mimic protein interface segments.
High energy storage density and ultrafast discharge in lead lutetium niobate based ceramics
Authors: Yang Xiaoming , Zhuo Fangping , Wang Chenxi , Liu Ying , Wang Zujian , Tailor Hamel , He Chao , Long Xifa
Published: March 2019

A novel antiferroelectric system possesses a high recoverable energy storage density, ultrafast charge/discharge properties and good fatigue resistance.
A novel aqueous sodium–manganese battery system for energy storage
Authors: Feng Yazhi , Zhang Qiu , Liu Shuang , Liu Jian , Tao Zhanliang , Chen Jun
Published: March 2019

A novel aqueous sodium–manganese battery system with a long life span of over 7000 cycles.
Self-floating nanostructured Ni–NiOx/Ni foam for solar thermal water evaporation
Authors: Wu Dandan , Qu Dan , Jiang Wenshuai , Chen Ge , An Li , Zhuang Chunqiang , Sun Zaicheng
Published: March 2019

Solar thermal water evaporation is a clean, sustainable, and energy-saving approach to fresh water generation compared with traditional methods.
Significantly enhanced room temperature electrocaloric response with superior thermal stability in sodium niobate-based bulk ceramics
Authors: Yu Ying , Gao Feng , Weyland Florian , Du Hongliang , Jin Li , Hou Lei , Yang Zetian , Novak Nikola , Qu Shaobo
Published: March 2019

This work simultaneously achieved a large temperature change (ΔT, ∼0.70 K) at room temperature and ultra-stable ΔT(±1.4% variation between 300 K with 380 K) in 0.78NaNbO3–0.22BaTiO3bulk ceramic.
An injectable nanocomposite hydrogel co-constructed with gold nanorods and paclitaxel-loaded nanoparticles for local chemo-photothermal synergetic cancer therapy
Authors: Liu Meiyan , Huang Pingsheng , Wang Weiwei , Feng Zujian , Zhang Jianhua , Deng Liandong , Dong Anjie
Published: March 2019

A nanocomposite hydrogel,AuNR/PTXmPECTgel, was fabricated forin situsynergetic chemotherapy and photothermal therapy for tumor inhibition.
Pressure effect on spin-driven multiferroicity in a Y-type hexaferrite
Authors: Zhai Kun , Su Na , Sun Jianping , Cheng Jinguang , Liu Zhongyuan , Sun Young
Published: March 2019

We have investigated the influence of pressure on the magnetoelectric multiferroicity of the Ba1.5Sr0.5Mg2Fe12O22 hexaferrite under hydrostatic pressures up to 3.08 GPa.
Biological relevance of cell-in-cell in cancers
Authors: Mackay Hannah L. , Muller Patricia A.J.
Published: March 2019

Cell-in-cell (CIC) is a term used to describe the presence of one, usually living, cell inside another cell that is typically considered non-phagocytic. Examples of this include tumour cells inside tumour cells (homotypic), mesenchymal stem cells inside tumour cells (heterotypic) or immune cells inside tumour cells (heterotypic). CIC formation can occur in cell lines and in tissues and it has been most frequently observed during inflammation and in cancers. Over the past 10 years, many researchers have studied CIC structures and a few different models have been proposed through which they can be formed, including entosis, cannibalism and emperipolesis among others. Recently, our laboratory discovered a role for mutant p53 in facilitating the formation of CIC and promoting genomic instability. These data and research by many others have uncovered a variety of molecules involved in CIC formation and have started to give us an idea of why they are formed and how they could contribute to oncogenic processes. In this perspective, we summarise current literature and speculate on the role of CIC in cancer biology.
Thermo‐electric field analysis of AC XLPE cable in monopole, bipole, and tripole DC operation modes
Authors: Chen Xiangrong , Yu Jingzhe , Zhou Hao
Published: March 2019

This paper presents a numerical analysis of thermo‐electric fields of 10 and 35 kV AC XLPE cables in monopole, and tripole DC operating modes based on conduction current measurements. DC conductivities and electric field thresholds of the space charge accumulation for XLPE materials were estimated at different temperatures and electric fields. The result showed that the electric field threshold of the space charge accumulation for the materials reduced with an increase of the temperature. DC currents of the cables were increased with the increase of the operating temperatures in the three DC operation modes. The maximum DC operation voltage of the cables increased with the decline of the operation temperature in the three DC operation modes. The maximum transient electric fields were below the threshold of the space charge accumulation for the cables in the tripole DC operation. The maximum transmission power of the 10 kV XLPE cable in the DC operation modes was at 60° C, whereas the maximum transmission power of the 35 kV XLPE cable was at 50° C. It was elucidated that the 10 kV AC XLPE cable could have more advantages than the 35 kV AC XLPE cable in the three DC operation modes.
Assessment of induced voltages in common and differential‐mode for a PV module due to nearby lightning strikes
Authors: Formisano Alessandro , Petrarca Carlo , Hernández Jesus C. , Muñoz‐Rodríguez Francisco Jose
Published: March 2019

Nearby lightning strikes are prone to induce overvoltage transients in photovoltaic (PV) modules and in their power conditioning circuitry, which can permanently damage the PV system. Therefore, it becomes important to establish a method for accurate assessment of such transients. To this aim, the authors propose a three‐dimensional (3D) semi‐analytical numerical method to study the electromagnetic transients caused in PV modules by nearby lightning strikes. The approach bases on a semi‐analytical expression of the magnetic vector potential generated by a geometrically complex lightning channel. The proposed method is able to calculate the transient overvoltage in a PV module, both in common and differential‐mode, taking also into account capacitive and inductive couplings between the internal circuit and the PV metallic frame. Both modes are required to design the surge protective devices (SPDs) in PV power systems. Comparing to the models in literature, the proposed approach explicitly considers the complex geometry of the lightning channel. Statistical analysis allows assessing the impact of channel geometry by randomly generating a number of likely lightning paths. Results show that the lightning‐induced overvoltage in a PV module is highly dependent on factors such as distance to the lightning channel and lightning channel geometry.
SVSM calculation of power system with high wind‐power penetration
Authors: Lin Shunjiang , Lu Yuan , Liu Mingbo , Yang Yuerong , He Sen , Jiang Hao
Published: March 2019

Calculation of the static voltage stability margin (SVSM) of power system with high wind‐power penetration must consider the uncertain fluctuation of power output from wind farms (WFs). On the basis of a continuous power flow (CPF) and improved affine interval (IAI) algorithm that considers quadratic terms, a new method to calculate the SVSM interval of a power system that considers the uncertain fluctuation intervals of WF output is proposed. Considering the high penetration of wind power, the power variation of the active load, and wind‐power fluctuation are assigned by all conventional generators, except the swing generator in the CPF calculation model. In the proposed IAI algorithm, the non‐linear second‐order sensitivities are considered to obtain a more accurate SVSM interval. With the correlation of different WF output intervals described by relative angles, as well as the independent intervals obtained by decorrelation of the correlated WF output intervals, the SVSM interval is calculated by the CPF and IAI algorithms. Take the IEEE 39‐bus system and an actual 964‐bus provincial power grid as examples, and compared with Monte Carlo method, the results show that the SVSM interval calculated by the proposed method is more accurate, and the computation time is significantly reduced.
Dual‐output DC/DC boost converter for bipolar DC microgrids
Authors: Rezayi Shafie , Iman‐Eini Hossein , Hamzeh Mohsen , Bacha Seddik , Farzamkia Saleh
Published: March 2019

This study presents a new step‐up DC/DC converter for bipolar DC microgrids. This relies on utilising a new converter topology which offers bipolar DC outputs with the key features of boosting the input voltage and balancing the output voltages. In addition, the proposed converter can transfer power from output terminals to the input side which leads to energy saving. Due to the microgrid's loading conditions, different modes can be considered, and the operational principles are analysed in details. Applying the circuit average method, the small signal model of the proposed converter is derived. Then the appropriate controllers are designed considering the small signal model of the converter in each mode. Finally, a prototype of the proposed converter has been implemented in the laboratory, and the experimental results have verified the converter's ability to balance the bipolar DC grid's voltages and its capability of transferring power in various microgrid's conditions.
Critical review on slope monitoring systems with a vision of unifying WSN and IoT
Authors: Yadav Devendra Kumar , Jayanthu Singam , Das Santos Kumar , Chinara Suchismita , Mishra Pragyan
Published: March 2019

Slope stability is one of the major geological concerns in open‐cast mines. The mining area slopes needs to be regularly monitored to detect occurrence of any slope failure prior to any catastrophe. An early warning system solves this purpose preventing loss of significant mass of human lives as well as property. This is a critical scrutiny which renders various techniques and methodologies regarding slope monitoring of open‐cast mine. Wireless sensor network (WSN) has been standing out as a productive competent tool for monitoring the tangible environmental structures by sensing the differences, processing this raw data and finally communicating the result to the web from where it can be referred for researches and predicting mechanisms. Internet of Things (IoT) comes into picture for communicating the sensed and processed data from the sensors to the application where it can be further analysed. In recent scenario, power issue is of great concern associated with deploying a real‐time monitoring system. This review depicts how WSN can be adopted and preferred to any other technologies used in slope monitoring due to its advantages it brings. Moreover, collaborative operation of WSN with IoT results in a more systematic, robust, energy‐efficient, cost‐effective real‐time monitoring approach.
Convolutional neural network based detection and judgement of environmental obstacle in vehicle operation
Authors: Qi Guanqiu , Wang Huan , Haner Matthew , Weng Chenjie , Chen Sixin , Zhu Zhiqin
Published: March 2019

Precise real‐time obstacle recognition is both vital to vehicle automation and extremely resource intensive. Current deep‐learning based recognition techniques generally reach high recognition accuracy, but require extensive processing power. This study proposes a region of interest extraction method based on the maximum difference method and morphology, and a target recognition solution created with a deep convolutional neural network. In the proposed solution, the central processing unit and graphics processing unit work collaboratively. Compared with traditional deep learning solutions, the proposed solution decreases the complexity of algorithm, and improves both calculation efficiency and recognition accuracy. Overall it achieves a good balance between accuracy and computation.
Plasma heating by magnetoacoustic wave propagation in the vicinity of a 2.5D magnetic null-point
Authors: Sabri S. , Poedts S. , Ebadi H.
Published: March 2019

Context. Magnetohydrodynamic (MHD) waves have significant potential as a plasma heating mechanism. Finding a suitable wave dissipation mechanism is a very tough task, given the many observational constraints on the models, and this has resulted in the development of an important research community in solar physics. The magnetic field structure has an important role in the solar corona heating. Here, we investigate in detail current sheet mode generation via magnetic reconnection and mode conversion releases some of the free magnetic energy and produces heating. In addition, energy conversion is discussed completely. Moreover, nonlinear effects on density variations and, in turn, mode conversion are pursued.

Aims. In order to assess the role of magnetoacoustic waves in plasma heating, we have modeled in detail a fast magneto-acoustic wave pulse near a magnetic null-point in a finite plasma-β. The behavior of the propagation and dissipation of the fast magneto-acoustic wave is investigated in the inhomogeneous magnetically structured solar corona. Particular attention is given to the dissipation of waves and coronal heating and energy transfer in the solar corona, focusing on the energy transfer resulting from the interaction of fast magneto-acoustic waves with 2.5D magnetic null-points.

Methods. The shock−capturing Godunov−type PLUTO code was used to solve the ideal MHD set of equations in the context of wave-plasma energy transfer.

Results. It is shown that magneto-acoustic waves could be a viable candidate to contribute significantly to the heating of the solar corona and maintain the solar corona at a temperature of a few million degrees. The temperature is not constant in the corona. Coronal heating occurs near magnetic null points. It is found that magnetic reconnection, phase mixing and mode conversion contribute to the heating. Moreover, nonlinear fast and slow magnetoacoustic waves are decoupled except inβ = 1 layer.
Detection of surface subsidence using SAR SENTINEL 1A imagery and the DInSAR method – a case study of the Belchatow open pit mine, Central Poland
Authors: Wajs Jaroslaw , Milczarek Wojciech J.
Published: March 2019

Open pit mining hazards monitoring is a crucial task. The paper focuses on the first analysis of surface subsidence in the open pit mining area obtained by Synthetic Aperture Radar active remote sensing technique. Presented methodology of Differential Interferometric SAR provides an excellent data source for mining vertical displacements monitoring. The study was performed in the Belchatow open pit lignite mine in Poland, Central Europe. The SAR SLC imageries acquired by the SENTINEL 1A satellite for the 124-descending track in two periods, between 03.10.2016-15.10.2016 and 15.10.2016-27.10.2016 have been used in the analysis. The post-proceed satellite line of sight (LOS) displacement indicates vertical changes of the surface within the dumping and excavation area. The analyzed region of interests (ROI) shows total subsidence of ca. -67mm, whereas the excavation areas show a trend of terrain uplift during the analyzed periods.
Simulation and analysis of collapsing vapor-bubble clusters with special emphasis on potentially erosive impact loads at walls
Authors: Ogloblina Daria , Schmidt Steffen J. , Adams Nikolaus A.
Published: March 2019

Cavitation is a process where a liquid evaporates due to a pressure drop and re-condenses violently. Noise, material erosion and altered system dynamics characterize for such a process for which shock waves, rarefaction waves and vapor generation are typical phenomena. The current paper presents novel results for collapsing vapour-bubble clusters in a liquid environment close to a wall obtained by computational fluid mechanics (CFD) simulations. The driving pressure initially is 10 MPa in the liquid. Computations are carried out by using a fully compressible single-fluid flow model in combination with a conservative finite volume method (FVM). The investigated bubble clusters (referred to as “clouds”) differ by their initial vapor volume fractions, initial stand-off distances to the wall and by initial bubble radii. The effects of collapse focusing due to bubble-bubble interaction are analysed by investigating the intensities and positions of individual bubble collapses, as well as by the resulting shock-induced pressure field at the wall. Stronger interaction of the bubbles leads to an intensification of the collapse strength for individual bubbles, collapse focusing towards the center of the cloud and enhanced re-evaporation. The obtained results reveal collapse features which are common for all cases, as well as case-specific differences during collapse-rebound cycles. Simultaneous measurements of maximum pressures at the wall and within the flow field and of the vapor volume evolution show that not only the primary collapse but also subsequent collapses are potentially relevant for erosion.
Flow Behavior in Side-View Plane of Pitching Delta Wing
Authors: Pektas Mehmet Can , Tasci Mehmet Oguz , Karasu Ilyas , Sahin Besir , Akilli Huseyin
Published: March 2019

In the present investigation, a delta wing which has 70° sweep angle, Λ was oscillated on its midcord according to the equation of α(t)=αm+α0sin(ωet). This study focused on understanding the effect of pitching and characterizing the interaction of vortex breakdown with oscillating leading edges under different yaw angles, β over a slender delta wing. The value of mean angle of attack, αm was taken as 25°. The yaw angle, β was varied with an interval of 4° over the range of 0°≤β≤ 16°. The delta wing was sinusoidally pitched within the range of period of time 5s≤Te≤60s and reduced frequency was set as K=0.16, 0.25, 0.49, 1.96 and lastly amplitude of pitching motion was arranged as α0=±5°.Formations and locations of vortex breakdown were investigated by using the dye visualization technique in side view plane.
Analysis of the velocity distribution in different types of ventilation system ducts
Authors: Peszyński Kazimierz , Olszewski Lukasz , Smyk Emil , Perczyński Daniel
Published: March 2019

The paper presents the results obtained during the preliminary studies of circular and rectangular ducts before testing the properties elements (elbows, tees, etc.)of rectangular with rounded corners ducts. The fundamental problem of the studies was to determine the flow rate in the ventilation duct. Due to the size of the channel it was decided to determine the flow rate based on the integration of flow velocity over the considered cross-section. This method requires knowledge of the velocity distribution in the cross section. Approximation of the measured actual profile by the classic and modified Prandtl power-law velocity profile was analysed.
Influence of Eccentricity and Angular Velocity on Force Effects on Rotor of Magnetorheological Damper
Authors: Šedivý Dominik , Ferfecki Petr , Fialová Simona
Published: March 2019

This article presents the evaluation of force effects on squeeze film damper rotor. The rotor is placed eccentrically and its motion is translate-circular. The amplitude of rotor motion is smaller than its initial eccentricity. The force effects are calculated from pressure and viscous forces which were measured by using computational modeling. Damper was filled with magnetorheological fluid. Viscosity of this non-Newtonian fluid is given using Bingham rheology model. Yield stress is not constant and it is a function of magnetic induction which is described by many variables. The most important variables of magnetic induction are electric current and gap width between rotor and stator. The simulations were made in finite volume method based solver. The motion of the inner ring of squeeze film damper was carried out by dynamic mesh. Numerical solution was solved for five different initial eccentricities and angular velocities of rotor motion.
Polyhedral meshing in numerical analysis of conjugate heat transfer
Authors: Sosnowski Marcin , Krzywanski Jaroslaw , Grabowska Karolina , Gnatowska Renata
Published: March 2019

Computational methods have been widely applied in conjugate heat transfer analysis. The very first and crucial step in such research is the meshing process which consists in dividing the analysed geometry into numerous small control volumes (cells). In Computational Fluid Dynamics (CFD) applications it is desirable to use the hexahedral cells as the resulting mesh is characterized by low numerical diffusion. Unfortunately generating such mesh can be a very time-consuming task and in case of complicated geometry - it may not be possible to generate cells of good quality. Therefore tetrahedral cells have been implemented into commercial pre-processors. Their advantage is the ease of its generation even in case of very complex geometry. On the other hand tetrahedrons cannot be stretched excessively without decreasing the mesh quality factor, so significantly larger number of cells has to be used in comparison to hexahedral mesh in order to achieve a reasonable accuracy. Moreover the numerical diffusion of tetrahedral elements is significantly higher. Therefore the polyhedral cells are proposed within the paper in order to combine the advantages of hexahedrons (low numerical diffusion resulting in accurate solution) and tetrahedrons (rapid semi-automatic generation) as well as to overcome the disadvantages of both the above mentioned mesh types. The major benefit of polyhedral mesh is that each individual cell has many neighbours, so gradients can be well approximated. Polyhedrons are also less sensitive to stretching than tetrahedrons which results in better mesh quality leading to improved numerical stability of the model. In addition, numerical diffusion is reduced due to mass exchange over numerous faces. This leads to a more accurate solution achieved with a lower cell count. Therefore detailed comparison of numerical modelling results concerning conjugate heat transfer using tetrahedral and polyhedral meshes is presented in the paper.