bluuebunny/crossref_metadata_2025 huggingface dataset:
Mortality Risk Factor Stratification in a Retrospective Cohort of Hospitalized Patients with Community Acquired Pneumonia
Authors: Sloan Meredith , Owings Anna , Glover Sarah , Liu Julia , Abraham George E. , Claggett Brian , Senitko Michal
Published: May 2023

Purpose A retrospective cohort was used to investigate the conditions that affected mortality in hospitalized community-acquired pneumonia (CAP) patients.Methods 1223 patients were identified based on diagnostic codes. T-tests, chi-squared tests, and logistic regression models were used to evaluate the data.Results There were 613 (50%) patients on proton pump inhibitors (PPIs) with a mortality rate of 26.3% vs 13.4% in non-PPI users (P < 0.001). Variables that increased the risk of death included: each decade of age, odds ratio (OR) = 1.15 (95% confidence interval 1.07 to 1.23), congestive heart failure OR = 2.06 (1.46 to 2.91), cancer OR = 1.66 (1.20 to 2.23), cardiovascular disease OR = 2.04 (1.19 to 3.49), and stroke OR = 1.53 (1.05 to 2.23). Statin use was associated with improved mortality, OR = 0.28 (0.13 to 0.59).Conclusion Statin use may improve and PPIs may worsen mortality in CAP.
Evaluation of patient safety competencies: Findings of the psychometric properties of the H-PEPSS in France and French-speaking Switzerland
Authors: Boloré Sylvain , Sovet Laurent , Guirimand Nicolas
Published: May 2023

Background Several initiatives have been implemented to develop, manage, and assess patient safety competencies, which are considered as a serious public health issue across the world. The Health Professional Education in Patient Safety Survey (H-PEPSS) is widely used as a psychometric scale for evaluating perceived patient safety competencies. The purpose of the study was to investigate the psychometric properties of the French version of H-PEPSS.Methods A total of 449 students enrolled in nursing and physiotherapy schools in France and French-speaking Switzerland completed a self-administered questionnaire.Results The 6-factor model demonstrated adequate goodness-of-fit statistics. The total score can be used as an overall measure of patient safety competence. In contrast to previous studies, the use of McDonald's omega was preferred to Cronbach's alpha to measure the composite reliability of the scale. Contrary to the original study, the “Understanding Human and Environmental Factors” Subscale showed inadequate reliability. This subscale has often been reported with the lowest reliability in previous studies. Scalar invariance between countries and partial scalar invariance between majors were observed.Conclusion Perceived patient safety competencies can be assessed and fairly compared across France and Switzerland as well as across nursing and physiotherapy students. Practical and research implications of the H-PEPSS are discussed.
INES: INteractive tool for construction and Extrapolation of partitioned Survival models
Authors: Gimeno-Ballester Vicente , Perez-Troncoso Daniel , Olry-Labry Antonio , Epstein David
Published: May 2023

Background
INES (INteractive model for Extrapolation of Survival and cost) provides an open-access tool powered by R that implements partitioned survival models (PSM). This article describes the properties of the tool, and the situations where INES may or may not be suitable.
Methods
INES is designed to be used by investigators or healthcare professionals who have a good grasp of the principles of economic evaluation and understand the strengths and weaknesses of partitioned survival models, but are not sufficiently familiar with a statistical package such as Excel or R to be able to construct and test a de-novo PSM themselves.
INES is delivered to the user via a batch file. Once downloaded to the user’s hard drive, it interacts with the user via a portable version of R with web interactivity built in shiny. INES requires absolutely no knowledge of R and the user does not need to have R or any of its dependences installed. Hence the user will deal with a standalone shiny app. Inputs (digitalized survival curves, unit costs, posology, hazard ratios, discount rate) can be uploaded from a template spreadsheet.
Results
An example of the inputs and outputs of INES are given that may serve as a tutorial.
Conclusion
INES offers a rapid, flexible, robust open access tool for calculating a PSM that can be used in many different contexts.
Formation and Stability of Nanoscrolls Composed of Graphene and Hexagonal Boron Nitride Nanoribbons: Insights from Molecular Dynamics Simulations
Authors: Lima Kleuton Antunes Lopes , Junior Luiz Antonio Ribeiro
Published: May 2023

Context Nanoscrolls are tube-like structures formed when a sheet or ribbon of material is rolled up into a cylinder, creating a hollow tube with a diameter on the nanoscale - much like papyrus. Carbon nanoscrolls have unique properties that make them useful in various applications, such as energy storage, catalysis, and drug delivery. In this study, we employed classical molecular dynamics simulations to investigate the formation and stability of nanoscrolls composed of graphene and hexagonal boron nitride (hBN) nanoribbons. Using a carbon nanotube (CNT) as a template to trigger their collapsing, we found that graphene/graphene, graphene/hBN, and hBN/hBN could form CNT-wrapped nanoscrolls at ultrafast speeds. We also confirmed that these nanoscrolls are thermally stable and discussed the other products formed from the interaction of these complexes and their temperature dependence. Gr/Gr and hBN/Gr nanoscrolls exhibit similar interlayer distances, while hBN/hBN nanoscrolls have wider interlayer distances than the other two types of composite nanoscrolls. These features suggest that hBN/hBN composite nanoscrolls could more efficiently capture small molecules due to their greater interlayer spacing.
Methods We conducted molecular dynamics (MD) simulations using the Forcite package in the Biovia Materials Studio software, which employs the Universal (UFF) and Dreiding (DFF) Force Fields. UFF models bonded interactions with a harmonic approximation for bond stretching, a three-term Fourier cosine expansion for angle bending, and Cosine-Fourier expansion terms for torsions and inversions. Non-bonded interactions are modeled using the Lennard-Jones potential for VDW interactions and atomic monopoles with a screened coulomb term for electrostatic interactions that vary with distance. DFF employs a rule-based approach to derive explicit parameters for its general force constants and geometry parameters based on simple hybridization rules instead of relying on specific atom combinations as UFF does. Unlike UFF, it does not generate parameters automatically. The force field is diagonal and includes harmonic valence terms and a cosine-Fourier expansion torsion term, while inversions follow the umbrella functional form defined by the Wilson out-of-plane definition. The Lennard-Jones potential describes van der Waals interactions, while atomic monopoles and a screened Coulombic term dependent on distance describe electrostatic interactions. Hydrogen bonding is described using an explicit Lennard-Jones 12-10 potential.
General, Open-Source Vertex Modeling in Biological Applications Using Tissue Forge
Authors: Sego T.J. , Comlekoglu Tien , Peirce Shayn M. , Desimone Douglas , Glazier James A.
Published: May 2023

Vertex models are a widespread approach for describing the biophysics and behaviors of multicellular systems, especially of epithelial tissues. Vertex models describe a wide variety of developmental scenarios and behaviors like cell rearrangement and tissue folding. Often, these models are implemented as single-use or closed-source software, which inhibits reproducibility and decreases accessibility for researchers with limited proficiency in software development and numerical methods. We developed a physics-based vertex model methodology in Tissue Forge, an open-source, particle-based modeling and simulation environment. Our methodology describes the properties and processes of vertex model objects on the basis of vertices, which allows integration of vertex modeling with the particle-based formalism of Tissue Forge, enabling an environment for developing mixed-method models of multicellular systems. Our methodology in Tissue Forge inherits all features provided by Tissue Forge, delivering open-source, extensible vertex modeling with interactive simulation, real-time simulation visualization and model sharing in the C, C + + and Python programming languages and a Jupyter Notebook. Demonstrations show a vertex model of cell sorting and a mixed-method model of cell migration combining vertex- and particle-based models. Our methodology provides accessible vertex modeling for a broad range of scientific disciplines, and we welcome community-developed contributions to our open-source software implementation.
Dual targeting ovarian cancer by Muc16 CAR-T cells secreting a bispecific T cell engager antibody for an intracellular tumor antigen WT1
Authors: Mun Sung Soo , Peraro Leila , Meyerberg Jeremy , Korontsvit Tatyana , Malviya Manish , Gardner Thomas , Kyi Chrisann , O’Cearbhaill Roisin E. , Liu Cheng , Dao Tao , Scheinberg David A.
Published: May 2023

Epithelial ovarian cancer is the most lethal of gynecological cancers. The therapeutic efficacy of chimeric antigen receptor (CAR) T cell directed against single antigens is limited by the heterogeneous target antigen expression in epithelial ovarian tumors. To overcome this limitation, we describe an engineered cell with both dual targeting and orthogonal cytotoxic modalities directed against two tumor antigens that are highly expressed on ovarian cancer cells: cell surface Muc16 and intracellular WT1. Muc16-specific CAR-T cells (4H11) were engineered to secrete a bispecific T cell engager (BiTE) constructed from a TCR mimic antibody (ESK1) reactive with the WT1-derived epitope RMFPNAPYL (RMF) presented by HLA-A2 molecules. The secreted ESK1 BiTE recruited and redirected other T cells to WT1 on the tumor cells. We show that ESK1 BiTE-secreting 4H11 CAR-T cells exhibited enhanced anticancer activity against cancer cells with low Muc16 expression, compared to 4H11 CAR-T cells alone, both in vitro and in mouse tumor models. Dual orthogonal cytotoxic modalities with different specificities targeting both surface and intracellular tumor-associated antigens present a promising strategy to overcome resistance to CAR-T cell therapy in epithelial ovarian cancer and other cancers.
Real-time, random-access organ screening for carbapenem-resistant Enterobacterales (CRE) reduces CRE- associated, donor-derived infection mortality in recipients
Authors: Zhou Wen-Yong , Shen Lei , Shi Jian-Xin , Gao Xing-Hui , Yang Jun , Fu Shi-Jie , Pan Xu-Feng , Zhu Min-Fang , Zhang Shen , Zhang Chong , Li Feng , Zhang Hai , Yao Feng , Tenover Fred C. , Tang Yi-Wei , Fang Wen-Tao
Published: May 2023

Purpose: Donor-derived infection (DDI) has become an important factor affecting the prognosis of lung transplantation patients. The risks versus benefits of using donor organs infected with multidrug-resistant organisms (MDRO), especially carbapenem-resistant Enterobacterales (CRE), are frequently debated. Traditional microbial culture and antimicrobial susceptibility testing at present fail to meet the needs of quick CRE determination for donor lung before acquisition. In this study, we explored a novel accurate screening method by using Xpert® Carba-R assay for CRE in donor lungs in a real-time manner to reduce CRE-associated DDI mortality.
Methods: This study was registered on chictr.org.cn (ChiCTR2100053687) on November, 2021. In the Xpert Carba-R screening group, donor lungs were screened for CRE infection by Xpert Carba-R test on bronchoalveolar lavage fluid (BALF) before acquisition. If the result was negative, donor lung acquisition and subsequent lung transplantation were performed. In the control group, the recipients underwent lung transplants without Xpert Carba-R screening. The incidence and mortality of CRE-associated DDI were collected and contrasted between the two groups.
Results: Multivariate analysis showed that CRE-related death due to DDI within 60 days was significantly lower in the Xpert Carba-R screening group than that in the control group (OR = 0.049, 95% CI = 0.003-0.736, p = 0.029).
Conclusion: Real-time CRE screening of donor lungs before transplantation at the point of care by the Xpert Carba-R helps clinicians formulate lung transplantation strategies quickly and reduces the risk of subsequent CRE infection improving the prognosis of lung transplantation.
Survival Impact of Immediate Complete Lymph Node Dissection for Chinese Acral and Cutaneous Melanoma with Micrometastasis in Sentinel Nodes: A Retrospective Study
Authors: Zhong Jingqin , Zou Zijian , Hu Tu , Sun Wei , Wang Chunmeng , Yan Wangjun , Luo Zhiguo , Liu Xin , Xu Yu , Chen Yong
Published: May 2023

Background Sentinel node biopsy (SNB) has become a critical part of standard surgical treatment for melanoma with no metastatic evidence. According to MSLT-II and DeCOG-SLT trials, for patients with positive sentinel nodes, immediate complete lymph node dissection (CLND) didn’t bring further benefit for patients’ survival. Argument remains among Chinese population with domination of acral subtypes whether CLND can be omitted. This study aims to investigate the impact of immediate CLND for SN positivity on relapse-free survival (RFS) in Chinese melanoma patients.Material and Methods Patients with acral or cutaneous melanoma of clinical stage I-II receiving SNB procedure and then detected with nodal micrometastasis were retrospectively identified at Fudan University Cancer Center (FUSCC) from January 2017 to December 2021. Clinicopathologic features and prognostic factors for RFS were analyzed.Results Among 381 patients who received SNB in the last five years, 130 (34%) cases with positive SN micrometastasis detected were identified in our study. 99 patients underwent immediate CLND while the other patients received observation alone. Among patients received CLND, the NSN positive rate was 22.2%. There were slightly less N1 stage in the CLND group compared to the non-CLND group, although the difference didn’t reach statistical significance (P = 0.075). There was no significant difference in RFS between the two groups (P = 0.184).Conclusions Immediate CLND didn’t bring further RFS benefit after an observation for Chinese melanoma with SN micrometastasis in real clinical practice, even for patients with acral subtype or more tumor burden such as thick Breslow invasion and ulceration.
Bibliometric Analysis of Trends in Stem Cell Therapy for Hip Osteoarthritis from 1990 to 2023
Authors: Qiu Binsong , Bi Qing
Published: May 2023

Background The rapid growth in the prevalence of hip osteoarthritis, in conjunction with the worldwide increase in the average age of the population, has attracted the interest of many researchers. Our objective was to identify research trends in stem cell therapy for hip osteoarthritis and to evaluate the most-reviewed high-quality scientific articles related to stem cells.Methods All stem cell therapy for hip osteoarthritis publications were retrieved from the Web of Science Core Collection database. We analyzed all publications by years of publication in this field, country, institution, total citations, and journal. Publication performance was assessed by numerous bibliometric criteria, like VOSviewer, to discover topic trends in the research landscape. At the same time, the 100 stem cell articles with the most citations were extracted and analyzed.Results A total of 1099 publications associated with stem cell therapy for hip osteoarthritis were included between 1990 and 2023. Globally, the country with the most published articles on stem cell treatment for hip osteoarthritis is the United States, with 713. Helsinki University had the most publications of any institution (n = 48). The journal "Osteoarthritis and Cartilage" has published 54 publications with a total of 3090 citations.Conclusion This study represents the latest bibliometric analysis of stem cell therapy for hip osteoarthritis. The main objective is to highlight present and prospective research hotspots for clinicians and researchers in the field.
Self-management support (SMS) in primary care practice: a qualitative focus group study of care professionals’ experiences
Authors: Timmermans Lotte , Boeykens Dagje , Sirimsi Muhammed Mustafa , De Vriendt Patricia , Decat Peter , Hecke Ann Van , Vermandere Mieke , Schoenmakers Birgitte , de Velde Dominique Van , Foulon Veerle
Published: May 2023

Background: To support self-management of chronically ill persons, innovative approaches of care practice are being developed. Unfortunately, many self-management supporting interventions struggle to achieve reliable and consistent improvements at various levels (patient, provider and healthcare system level). One possible strategy to facilitate translating theory into practice, is to consider the healthcare professionals’ perspective prior to the development of new interventions. An exploration of their knowledge and opinion about barriers and facilitators is necessary before employing any self-management support (SMS) intervention. Therefore, our study aims to explore care professionals’ perspectives about SMS within the Flemish primary care setting.
Methods: This study used a qualitative study design to examine SMS in primary care setting. Five focus groups were conducted, grouped into three waves. Participants were healthcare professionals in Flanders representing different disciplines and settings. A maximum variation purposive sampling was used to recruit participants. For the data analysis, the framework of thematic networks by Attride-Stirling was applied.
Results: A total of 34 healthcare professionals participated. Three global themes related to SMS were derived from the thematic analysis: (1) Characteristics, (2) Support strategies, (3) Barriers and facilitators. SMS was characterised as a collaboration-based and person-centred approach. A variety of supporting strategies were mentioned by the focus group participants. Most strategies consisted of informing and educating patients. Complementary to individual strategies, collaborative strategies were deemed necessary to support self-management. Regarding barriers and facilitators, different patient-related factors were identified. Additionally, competencies of healthcare providers and external factors seem to hinder the implementation of SMS in practice.
Conclusions: This focus group study highlights the importance of a collaborative, person-centred approach to SMS in the context of chronic diseases. Our findings point to the need for interventions that raise awareness and address barriers associated with SMS. Since generic SMS does not exist, the road to success is a growth process in which support must be adapted to the individual patient.
Ibrutinib plus fludarabine, cyclophosphamide and rituximab (iFCR) as initial treatment in chronic lymphocytic leukemia/ small lymphocytic leukemia with or without TP53 aberrations: A prospective real-world study in Chinese cohort
Authors: ZHU Hua-Yuan , Miao Yi , Sha Yeqin , Xia Yi , Qin Shu-Chao , Jiang Rui , Dai Luomengjia , Shen Hui , Qiu Tonglu , Wu Wei , Qiu Jingyan , Yang Yilian , Ding Chong-Yang , Wu Yujie , Fan Lei , Xu Wei , Li Jianyong
Published: May 2023

Time-limited treatment strategies in first line treatment of chronic lymphocytic leukemia/small lymphocytic leukemia (CLL/SLL) were comprehensively explored. Thirty-four previously untreated, young fit CLL/SLL patients who initiated iFCR regimen between January 2019 and Match 2021 were included in our cohort. iFCR were administered every 28-day cycle, with a maximum of six cycles. Patients who achieved complete remission or complete remission with incomplete recovery (CR/CRi) and bone marrow (BM) undetectable minimal residual disease (uMRD) 2 years after iFCR initiation were feasible to discontinue ibrutinib maintenance. 61.8% (21/34) patients had IGHV unmutated status and 17.6% (6/34) patients had TP53 mutation and/or del(17p). CR/CRi rate was 35.3% (12/34) and BM uMRD rate was 41.2% (14/34) after three cycles of iFCR, and increased to 55.9% (19/34) after eight cycles. The best response of CR/CRi rate and BM uMRD rate were both 73.5% (25/34). With the median follow-up of 33 months, the 3-year PFS and OS rate was 80.0% and 95.5%, respectively. CR/CRi rate and BM uMRD rate was comparable between patients with IGHV mutated and unmutated status without TP53 aberrations, while all patients with TP53 aberrations failed to achieve sustainable CR/CRi or BM uMRD. The most common hematological adverse events were neutropenia (25/34, 73.5%) and thrombocytopenia (24/34, 70.6%) and the most common non-hematological adverse events were nausea (21/34, 61.8%), fatigue (16/34, 47.1%) and vomiting (15/34, 44.1%). The iFCR regimen could achieve high response rate and proportion of uMRD as initial treatment for young fit CLL/SLL patient absence of TP53 aberration with acceptable overall tolerability.
Open set domain adaptive method based on energy separation strategy
Authors: Chai Hao , Wang Shengsheng , Long Sifan , Hao ZhiWei , Li Yiyang
Published: May 2023

Open Set Domain Adaptation (OSDA) aims to reduce the variation across domains while distinguishing between known samples and unknown samples. However, existing OSDA methods are based on deep neural network classifiers to separate unknown samples, which leads the network to produce overconfident predictions and fails to establish the boundary between the known and the unknown. We propose an Energy-based Open Set Domain Adaptation method (EOS). Specifically, EOS is a new two-stage approach of separation followed by alignment. We use an energy-based anomaly detection strategy as a separation method for unknown samples, transforming the traditional K-way classification task into a K+1-dimensional classifier that uses an additional dimension to model the uncertainty of Out-of-distribution (OOD) samples. Then, we use a coarse-to-fine separation method to continuously adjust the separation results and add the exact separation results as weights in the alignment process, weighing their importance to the feature distribution alignment. In the alignment phase we also optimize our separation network module at the same time, so that the module can be better adapted with invariant features. We have done experiments on the standard ground Office-31, Office-Home, and VisDA-2017 benchmarks, and the results show that our approach outperforms our competitors in most cases.
Agaricus Subrufescens Ameliorates Ovarian Dysfunction and Regulates Altered Biochemical Parameters in Rats with Letrozole Induced Polycystic Ovarian Syndrome
Authors: Bukke Sarad Pawar Naik , PATHANGE Bharghava Bhushan Rao , KARUMANCHI Srikanth Kumar , MARRI Jalaiah , BOYINA Revathi , MANCHIKALAPATI Kavya , Bhargavi MANCHIKALAPATI , ODOMA Saidi , BELLO Hussaini
Published: May 2023

Objective To examine the impact of an ethonolic extract of Agaricus subrufescens on rat models of Polycystic Ovarian Syndrome (PCOS) produced by letrozole.Methods Thirty female Wistar rats were split into five six-rat groups. Negative controls received 1 mL of 0.5% carboxy methylcellulose (CMC). Other groups received letrozole (1 mg/kg) for 21 days to induce PCOS. Positive control animals were slaughtered on day 22. The test and standard groups received treatment from the 22nd to the 36th day. The test group received Agaricus subrufescens ethanoic extract (200 mg/kg, 400 mg/kg, p.o.) and the standard group clomiphene citrate (1 mg/kg). Estimated blood glucose, total cholesterol, triglycerides, and hormonal changes like increased testosterone, oestrogen, and decreased progesterone with menstrual irregularity confirmed by vaginal smears and histopathological ovary changes in polycystic ovarian disease control.Results Agaricus subrufescens reduced blood glucose, testosterone, anovulation, and menstrual irregularity. All therapies markedly corrected SGOT and SGPT levels. Letrozole-induced PCOS rats had elevated urea and creatinine. This study suggests that Agaricus subrufescens therapy protects renal function by lowering serum urea and creatinine. In letrozole-induced PCOS rats, suppressing hepatic synthesis, increasing ovarian follicle immaturity, and boosting androgen discharges increase liver and ovary weight. Endocrine organ weight decreased in all treatment groups. PCOS control histopathology indicated more cysts and theca lutein cells. PCOS control rats had more cysts than treatment groups.Conclusion Oral letrozole produced polycystic ovarian disease in this research. It showed elevated blood glucose, total cholesterol, triglycerides, and hormonal changes like increased testosterone and oestrogen and decreased progesterone with menstrual irregularity confirmed by vaginal smears and histopathological changes in the ovary of polycystic ovarian disease control. Blood glucose, total cholesterol, and testosterone levels dropped in Agaricus subrufescens treatment groups.
HSFO: Hunter Sail Fish Optimizer enabled deep learning for single document abstractive summarization based on semantic role labelling for Telugu text
Authors: Aluri Lakshmi , D Latha
Published: May 2023

Accessing information from online has become difficult problem due to the internet's explosive rise in textual resources. User’s frequently sought for topic summaries from multiple sources to satisfy their informational demands. Single document abstractive summarization is significant role in Natural Language Processing (NLP) aiming to generate concise summary of source text from single document. Method of producing natural language summaries from text, keeping key points of the input document as such is a challenging task. In this research, hybrid optimization algorithm, namely proposed Hunter Sail Fish Optimizer (HSFO) is used leading to abstractive summarization. Here, acquired document is allowed for Semantic Role Labeling (SRL), at which Stanza tool is used for extraction of Predicate Argument Structures (PAS). Next to SRL, optimized features are generated by computation of semantic similarity using Wave-Hedges metrics. Moreover, semantic feature clustering of PAS is performed using Bayesian Fuzzy Clustering (BFC). Then, feature score is generated by utilization of HSFO for parameter selection, leading to abstractive summarization by Long Short-Term Memory-Convolutional Neural Network (LSTM-CNN). Here, HSFO is devised by combining Hunter-Prey Optimizer (HPO) and Sail Fish Optimizer (SFO). The dataset used in this work is Telugu dataset, from which text document in the sentence form is acquired. Finally, performance of HSFO_LSTM-CNN is analyzed by using four performance measures, precision, recall, F-measure, and Rouge, which shows superior values of precision as 0.887, recall as 0.925, F-measure as 0.906, and rouge as 0.815.
Telerehabilitation in patients with recent hospitalisation due to Acute Decompensated Heart Failure: protocol for the Tele-ADHF randomised controlled trial
Authors: Leunen Mayke M.C.J. van , De Lathauwer Ignace , Verstappen Cindy C.A.G. , Visser-Stevelink Dianne M.G. , Brouwers Rutger W.M. , Herkert Cyrille , Tio René A. , Spee Ruud F. , Lu Yuan , Kemps Hareld M.C.
Published: May 2023

Background Cardiac rehabilitation in patients with chronic heart failure (CHF) has favourable effects on exercise capacity, the risk at hospital (re-)admission and quality of life. Although cardiac rehabilitation is generally recommended it is still under-utilised in daily clinical practice, particularly in frail elderly patients after hospital admission, mainly due to low referral and patient-related barriers. Cardiac telerehabilitation (CTR) has the potential to partially solve these barriers. The purpose of this study is to evaluate the effects of CTR as compared to standard remote care after hospital admission on physical functional capacity in CHF patients.Methods In this randomised controlled trial, 64 CHF patients will be recruited during hospitalisation for acute decompensated heart failure, and randomised to CTR combined with remote patient management (RPM) or RPM alone (1:1). All participants will start with RPM after hospital discharge for early detection of deterioration, and will be up titrated to optimal medical therapy before being randomised. CTR will start after randomisation and consists of an 18-week multidisciplinary programme with exercise training by physical and occupational therapists, supported by a (remote) technology-assisted dietary intervention and mental health guiding by a physiologist. The training programme consists of three centre-based and two home-based video exercise training sessions followed by weekly video coaching. The mental health and dietary programme are executed using individual and group video sessions. A wrist-worn device enables remote coaching by the physical therapist. The web application is used for promoting self-management by the following modules: 1) goal setting, 2) progress tracking, 3) education, and 4) video and chat communication. The primary outcome measure is physical functional capacity evaluated by the Short Physical Performance Battery (SPPB) score. Secondary outcome measures include frailty scoring, recovery after submaximal exercise, subjective health status, compliance and acceptance to the rehabilitation programme, and readmission rate.Discussion The Tele-ADHF trial is the first prospective randomised controlled trial designed for evaluating the effects of a comprehensive combined RPM and CTR programme in recently hospitalised CHF patients. We hypothesize that this intervention has superior effects on physical functional capacity than RPM alone.Trial registration: Netherlands Trial Registry (NTR) NL9619, registered 21 July 2021.
Potential Erosion Mapping Using Machine Learning Methods (Case Study: Rud-e-Faryab Basin, Bushehr Province, Iran)
Authors: Damaneh Javad Momeni , Safdari Ali Akbar , Azarnejad Nazanin , Ghorbani Majid , Panahi Fatemeh , Loppi Stefano
Published: May 2023

Purpose.
The requirement of soil erosion management is to provide appropriate solutions which can be obtained by recognizing the state of soil erosion. The purpose of the study is to model the potential erosion using 10 environmental variables and 10 models in BIOMOD-2 package in R software and to evaluate the stability of the model in order to be aware of the sensitivity of erosion in Rud-e-Faryab basin in Bushehr province.
Methods. In addition, the location of five dominant erosions of the basin was recorded using GPS. These events were classified into two groups of training and validation with a ratio of 70 to 30. In order to evaluate the stability, the BIOMOD-2 package model was repeated 10 times. The efficiency of the model was evaluated using ROC, KAPPA and TSS.
Results. According to stability results, the best models are determined as GLM model with the accuracy of above 70% in low-rated waterway erosion, RF model with the accuracy of above 80% in medium-rated waterway erosion, ANN and SRE models with 100% accuracy in medium-rated rill erosion, MARS model with accuracy above 60% in high-rated rill erosion and GLM model with accuracy above 80% in medium-rated stream bank erosion according to all three validation parameters.
Conclusion. These results indicate high agreement with studies which have used the vector machine models as an effective tool in preparing the potential erosion map of watersheds. In general, it can be said that vector machine methods are a helpful new approach for land use planning and erosion risk management.
Modelling the degradation of acidic and alkaline printing paper
Authors: Tétreault Jean , Vedoy Diogenes , Bégin Paul , Sabrina Paris Lacombe , Dupont Anne-Laurence
Published: May 2023

There has always been an interest in the professional communities of libraries, archives and conservation science to find ways of estimating the rate of degradation of paper under archival conservation conditions. Previously we reported a number of considerations for developing a kinetic degradation model based on Whatman no.1 paper. In the present research, this model was extended to 10 different papers and validated. Various physical and chemical properties of acidic, neutral, and alkaline papers were measured, such as the degree of polymerization (DP), tensile strength, equilibrium moisture content (EMC), and pH, as well as alkaline reserve when applicable. The activation energy (Ea) based on DP of cellulose and zero-span tensile strength were determined. Ea and pH had the most significant influence on the simulated decay of paper. Papers with a high Ea (> 120 kJ mol-1), alkaline such as those containing at least 2% CaCO3, and acidic –but good printing quality papers made of bleached chemical pulp– were found the most durable in ambient conditions. Papers with a lower Ea (< 110 kJ mol-1) such as lignocellulosic papers containing significant amount of mechanical pulp were much less stable over time. Whatman filter papers, used as models of pure cellulosic papers, were found to have low Ea despite the good quality cotton fibers. A generic isoperm equation based on Ea was developed to predict the changes in the state of papers under various climatic conditions, and was applicable independently of the pH of the paper. The model developed allows a better quantification of the deterioration rate of printing papers such as those that are currently, and will be in the future, found in our archival collections.
Thermal response of a prototype building with composite construction using LGS-Ferrocement sandwich wall panels.
Authors: Patil Nikhil , Kulkarni Mrudula , Lele Mandar , Shinde Sumant
Published: May 2023

In India, the modular precast construction sector, light gauge steel or commonly known as cold-formed steel and precast Ferrocement composite structures are gaining attention. This composite construction is a sustainable way of construction, leaving a low carbon footprint, as compared to conventional RCC construction. It enables fast construction with lower overheads, such as material transportation, labor cost, and amazing speed of construction thus making it an overall cost effective technology. The technology for typical G+5 residential building made of precast ferrocement panels combined with light gauge steel composite structure have been established. It claims to offer the practically enhanced solution to substitute the conventional RCC structure. Once structural performance is established, it is important to establish the thermal performance of this innovative construction technology for residential use purpose. This article represents the laboratory prototype study of residential space subjected to temperature variation, which may affect the comfort of the dwellers, energy requirement for maintaining working temperature for the building. Analytical and experimental approach establishes the thermal response of this precast composite construction technology and supports its futuristic development.
Bayesian optimization of wall-normal blowing and suction-based flow control of a NACA 4412 wing profile
Authors: Mallor Fermin , Semprini-Cesari Giacomo , Mukha Timofey , Rezaeiravesh Saleh , Schlatter Philipp
Published: May 2023

Active flow-control techniques have shown promise for achieving high levels of drag reduction. However, these techniques are often complex and involve multiple tunable parameters, making it challenging to optimize their efficiency. Here, we present a Bayesian optimization (BO) approach based on Gaussian process regression (GPR) to optimize a wall-normal blowing and suction control scheme for a NACA 4412 wing profile at two angles of attack: 5 and 11 degrees, corresponding to cruise and high-lift scenarios, respectively. An automated framework is developed by linking the BO code to the CFD solver OpenFOAM. RANS simulations (validated against high-fidelity LES and experimental data) are used in order to evaluate the different flow cases. BO is shown to provide rapid convergence towards a global maximum, even when the complexity of the response function is increased by introducing a model for the cost of the flow control actuation. The importance of considering the actuation cost is highlighted: while some cases yield a net drag reduction (NDR), they may result in an overall power increase. Furthermore, optimizing for NDR or net power reduction (NPR) can lead to significantly different actuation strategies. Finally, by considering losses and efficiencies representative of real-world applications, still a significant NPR is achieved in the 11° case, while net power reduction is only marginally positive in the 5° case.
A General Solution for Rotating Lattices of Identical Point Vortices
Authors: Robertson Phillip
Published: May 2023

The rotating equilibrium solutions of N identical point vortices are the minimal energy projections of a higher dimensional object to the xy plane, in this case, an N - 1 dimensional regular simplex. Parameterizing the point vortex Hamiltonian with this fundamental geometrical object leads to a simple bivector condition which determines the equilibrium states and resolves the origin of the asymmetric solutions. This novel approach uses the geometric product and the multivector derivative, ∂X, of the Hamiltonian in the geometric algebra, Cl(N - 1, 0) to find a geometric condition which determines the equilibrium states. The resulting bivector equation is then used as the input to an optimizer which rotates a simplex until the equilibrium condition is met, leading to a wealth of new solutions. If the vertices of the oriented simplex are projected to the x-axis, the values form the roots of the Hermite polynomials, HN(x), and obey the Stieltjes relations, capturing the collinear solutions. The vortex simplex exhibits a striking geometrical connection with the amplituhedron of quantum field theory and gives deep insight into the quantization of a classical system.
Climatic shocks and food security among agricultural households in Togo
Authors: GNEDEKA Kodjo Théodore , WONYRA Kwami Ossadzifo
Published: May 2023

The general objective of this paper is to analyse the effect of climate shocks on the food security of agricultural households in Togo. The generalized ordered logit model and the fixed-effects ordered logistic regression were applied to data from the EHCVM, (2018) and QUIBB, 2011 and 2015 conducted by INSEED in Togo. The Food Insecurity Experience Scale and the food consumption score are used as food security indicators. The study results reveal that climate shocks positively affect moderate and severe food insecurity among agricultural households. However, farm households that have experienced climate shocks but report being wealthy, possessing social capital, or having access to agricultural credit have a low probability of being food insecure in Togo. The study suggests policies to strengthen the resilience of farm households to climate shocks to improve their food security.
JEL code: O12, Q54, Q18
Universal Gibbons-Hawking-York term for theories with curvature, torsion and non-metricity
Authors: Erdmenger Johanna , Heß Bastian , Matthaiakakis Ioannis , Meyer René
Published: May 2023

Motivated by establishing holographic renormalization for gravitational theories with non-metricity and torsion, we present a new and efficient general method for calculating Gibbons-Hawking-York (GHY) terms. Our method consists of linearizing any nonlinearity in curvature, torsion or non-metricity by introducing suitable Lagrange multipliers. Moreover, we use a split formalism for differential forms, writing them in (n-1)+1(n−1)+1 dimensions. The boundary terms of the action are manifest in this formalism by means of Stokes’ theorem, such that the compensating GHY term for the Dirichlet problem may be read off directly. We observe that only those terms in the Lagrangian that contain curvature contribute to the GHY term. Terms polynomial solely in torsion and non-metricity do not require any GHY term compensation for the variational problem to be well-defined. We test our method by confirming existing results for Einstein-Hilbert and four-dimensional Chern-Simons modified gravity. Moreover, we obtain new results for torsionful Lovelock-Chern-Simons and metric-affine gravity. For all four examples, our new method and results contribute to a new approach towards a systematic hydrodynamic expansion for spin and hypermomentum currents within AdS/CFT.
MİRASTAN FERAGAT SÖZLEŞMESİNDEN MİRAS SÖZLEŞMESİNE ÖZGÜ SEBEPLERLE DÖNME
Authors: KARTAL Dilşah Buşra
Published: May 2023

Mirastan feragat sözleşmesi mirasbırakan ve mirasçı arasında resmi vasiyetname şekline uyularak düzenlenen bir sözleşmedir. Bu sözleşmeye göre feragat eden kişi, mirasbırakanın mirasından pay alamaz. Yani feragat eden, beklenen mirasçı sıfatını kaybeder. Mirastan feragat sözleşmesi ivazlı veya ivazsız olarak düzenlenebilir. Mirastan feragat sözleşmesi olumsuz miras sözleşmesi niteliğinde olduğu için miras sözleşmelerine ilişkin hükümler de bünyesine uygun düştüğü ölçüde mirastan feragat sözleşmesine uygulanır. Miras sözleşmeleri iki taraflı işlemler oldukları için vasiyetnamelerden farklı olarak tek taraflı şekilde ortadan kaldırılmaları kural olarak mümkün değildir. Ancak kanunkoyucu Türk Medeni Kanunu’nun 546. ve 547. maddelerinde miras sözleşmelerinin tek taraflı irade açıklaması ile ortadan kaldırılmasına imkan tanımıştır. Çalışmamız kapsamında söz konusu düzenlemelerin mirastan feragat sözleşmesine ne şekilde uygulanacağı incelenmektedir. Bu kapsamda mirastan feragat sözleşmesinin miras sözleşmesine özgü sebeplerle, tarafların tek taraflı irade açıklaması ile sona erdirilmesine ilişkin şartlar ve sona ermenin hükümleri değerlendirilmiştir. Bunlara ek olarak mirasbırakana mirastan feragat sözleşmesinden serbestçe dönme hakkının tanınıp tanınamayacağı da açıklanmıştır.
Does the adoption of Ind AS affect the performance of firms in India?
Authors: M. N. Nikhil , Chakraborty Suman , B. M. Lithin , Shawn Lobo Lumen
Published: May 2023

The increasing prevalence of IFRS adoption has resulted in enhanced transparency, accounting quality, and comparability of financial information among firms, especially in emerging markets worldwide, including India. Nonetheless, the question of whether the adoption of IFRS has led to improved firm performance persists. To address this question, this study examines the impact of transitioning from India’s GAAP-based accounting standards to IFRS-converged standards (Ind AS) on non-financial firms’ performance from 2013 to 2022. The empirical findings reveal that the convergence of Indian accounting standards with IFRS significantly improves firm performance, as demonstrated by a positive coefficient of 0.0166 for Ind AS in the fixed-effect model. The study also validates the original empirical findings using the return on equity (ROE) measure of firm performance, which yielded a coefficient of 0.0197, further confirming that the adoption of Ind AS leads to an increase in the performance of Indian firms. These results contribute new insights to the existing IFRS literature and have implications for policymakers and managers.
EFFECT OF VIRTUAL REALITY TRAINING ON BALANCE AND FUNCTIONALITY IN CHILDREN WITH CEREBRAL PALSY: A RANDOMIZED CONTROLLED TRIAL
Authors: FİDAN Öznur , GENÇ Arzu
Published: May 2023

Purpose: The aim of this study was to investigate the effectiveness of virtual reality training on balance and functionality in children with Cerebral Palsy.

Methods: Children with spastic Cerebral Palsy were randomly divided into the virtual reality training group (27 children, mean age: 9.2 years) and control group (25 children, mean age: 9.4 years). The virtual reality training group received virtual reality training using the XBox One Kinect gaming system and the control group received conventional physiotherapy training for eight weeks. The Pediatric Balance Scale, The Gross Motor Function Measurement-88, The Quality of Upper Extremity Skills Test, The Functional Reach Test, The Sit to Stand Test and The Pediatric Disability Evaluation Inventory were measured at baseline and after treatment sessions.

Results: Total motor function, upper extremity skills and balance in both groups improved after training (p < 0.05). A comparison between groups demonstrated that the improvements in upper extremity functions was greater in the control group than in the virtual reality training group (p < 0.05).

Conclusion: The results of our study showed that Kinect-based virtual reality training is beneficial in improving balance, motor function and upper extremity skills in children with Cerebral Palsy.
A COMPARISON OF MANUAL THERAPY AND EXTRACORPOREAL SHOCKWAVE THERAPY IN PATIENTS WITH CARPAL TUNNEL SYNDROME
Authors: TORUN Neslihan , TUNCER Ayşenur
Published: May 2023

Purpose: To investigate the effects on pain, symptom severity, and functionality of different physiotherapy methods applied to patients with carpal tunnel syndrome and to evaluate the advantages of these over each other.

Methods: A total of 75 patients (69 females, 6 males) aged 25-60 years were separated into 3 groups. The patients in Group 1 were given a home exercise program (HP), including median nerve and tendon gliding exercises. Group 2 received the same HP plus manual therapy (MT), including soft tissue and joint mobilisation. Group 3 received the same HP plus extracorporeal shockwave therapy (ESWT). Pain severity was evaluated with a Visual Analog Scale. Symptom severity and levels of functionality were evaluated with the Boston Carpal Tunnel Syndrome Questionnaire and the Cochin Hand Function Questionnaire. All the patients were evaluated before and after treatment.

Results: While there was a significant decrease in the resting and activity pain levels of each 3 groups after the treatment (p 0.05). However, the pain values of these two groups were significantly decreased compared to the EP group (p
NÖROMUSKÜLER HASTALIKLARDA GÖRÜLEN POSTÜR BOZUKLUĞU İLE HASTALIK ŞİDDETİ, FONKSİYONEL KAPASİTE, GÜNLÜK YAŞAM AKTİVİTELERİ VE DENGE ARASINDAKİ İLİŞKİNİN ARAŞTIRILMASI
Authors: DEMİRHAN İzel , KILINÇ Muhammed
Published: May 2023

Amaç: Bu çalışmanın amacı, nöromusküler hastalığa sahip erişkin bireylerde postür bozukluklarını araştırmak ve postür bozukluklarının hastalık şiddeti, fonksiyonel kapasite, günlük yaşam aktiviteleri, denge ve düşme ile ilişkisini belirlemektir.

Yöntem: Çalışmaya nöromusküler hastalık tanısı konan ve yaş ortalaması 36,34 ± 14,03 yıl olan 47 hasta dahil edilmiştir. New York Postür Derecelendirme Ölçeği (NYPD) ile genel vücut postürü, fleksible ruler ile torakal kifoz açısı (TKA)- lumbal lordoz açısı (LLA) değerlendirilmiştir. Skolyometre kullanılarak olası skolyoz varlığı ve pelvik asimetri değerlendirilmiştir. Üst Ekstremite (ÜEFS) ve Alt Ekstremite Fonksiyon İndeksi (AEFS) ile hastalık şiddeti, 2 Dakika Yürüme Testi (2DKYT) ile fonksiyonel kapasite, Zamanlı Kalk Yürü Testi (ZKYT) ile denge ve düşme riski, Fonksiyonel Bağımsızlık Ölçeği (FIM) ile günlük yaşam aktiviteleri kaydedilmiştir.

Sonuçlar: Postüral deformitelerin değerlendirilmesi sonucunda hastaların NYPD’si ortalamasının 40,24±9,56 olduğu belirlenmiştir. Yapılan ölçümlerde hastaların %46,34’ünde TKA’nın, %24,39’unda ise LLA’nın açısının norm değerlerin dışına çıktığı ve skolyometre ölçümleri sonucunda 30 hastada (%73,2) olası skolyoz varlığı, 11 hastada (%26,8) spinal asimetri olduğu, 27 hastada (%65,9) ise pelvik asimetri olduğu bulunmuştur. NYPD ile ÜEFS, 2DKYT, FIM ve ZKYT arasında istatiksel olarak anlamlı ilişki olduğu belirlenmiştir (p