bluuebunny/crossref_metadata_2025 huggingface dataset:
Avaliação pré-clínica dos mecanismos de ação da galectina-3 na progressão da aterosclerose: uma revisão narrativa
Authors: Colombo Pedro Bortoleto , Camargo João Victor Silveira , Campo Vanessa Leiria , Ribeiro Aline Barbosa
Published: November 2023

A aterosclerose é uma doença complexa com etiologia multifatorial relacionada a fatores de risco metabólicos e oxidativos e que corresponde a uma das principais causas do desenvolvimento de doença cardiovascular. Entre as principais manifestações clínicas estão cardiopatia isquêmica, acidente vascular cerebral isquêmico e doença arterial periférica (HERRINGTON et al., 2016). O insulto ao endotélio arterial, decorrente de diferentes disfunções metabólicas, gera uma cascata de reações inflamatórias as quais são responsáveis por gerar as lesões ateroscleróticas. Assim, evidencia-se a importância da liberação de fatores inflamatórios pelas células imunológicas e os mediadores que estimulam a ação dessas células (FALK, 2006).
O uso de inibidores de SGLT2 como tratamento adjuvante da aterosclerose: uma revisão integrativa
Authors: Silva Thales Roque Bonifácio da , Garcia Lívia Mello , Mendonça Lorena Vieira , Neca Mariana Amorim , Anjos Yago Lazinho dos , Ribeiro Aline Barbosa
Published: November 2023

Os inibidores do cotransportador de sódio-glicose tipo 2 (SGLT2i) agem no túbulo proximal do rim, levando à redução da reabsorção tubular de glicose com subsequente aumento da excreção urinária de glicose (glicosúria) e natriurese, bem como alterações osmóticas (RAU et al., 2021). Sabe-se que a síndrome metabólica e a Diabetes Mellitus tipo 2 (DM2) estão associadas ao aumento dos níveis de cálcio na artéria carótida e placas ateroscleróticas na aorta abdominal (TANAKA et al., 2022), sendo esses fortes fatores de risco para o desenvolvimento de morte cardiovascular, infarto do miocárdio ou acidente vascular cerebral isquêmico, insuficiência cardíaca e complicações nos membros (FERREIRA et al., 2020).
Tratamento farmacológico na síndrome do ovário policístico: uma revisão da literatura
Authors: Cunha Amanda Sapi , Ribeiro Filipe Virgílio , Jabbour Neto Fouad Gebrael , Hernandez Laura Maria Bolleli , Cardoso Maria Eduarda Bonaldi , Batista Sérgio Luchini
Published: November 2023

A síndrome do ovário policístico (SOP) é uma das endocrinopatias mais frequentes nas mulheres em idade reprodutiva. Caracteriza-se por morbidade elevada devido aos aspectos estéticos e por repercussões metabólicas importantes. Embora a sua patogênese permaneça pouco esclarecida, envolve uma desordem multigênica complexa, incluindo anormalidades no eixo hipotálamo-hipófise-ovariano e na esteroidogênese, bem como resistência insulínica.
Metazoários na Netflix: abordagem de metodologias ativas de ensino no curso de medicina
Authors: Mendonça Wellinton da Rocha , Pelicano  Laura Colombo , Lopes Maria Fernanda Cassola , Gomes Talita de Carvalho , Tefé-Silva Cristiane
Published: November 2023

O ensino médico é pautado na segmentação em áreas de conhecimentos, em que o professor é o maior detentor de conhecimentos e saberes sobre o conteúdo a ser transmitido, realizando o mesmo por meio de aulas expositivas centrada somente na transmissão unidirecional do conteúdo, senado este modelo conhecido como tradicional e elaborado por Flexner desde 1910. No entanto, em 2001 por meio da Diretriz Curriculares Nacional para o Curso de Medicina (DCN), propostas foram desenvolvidas visando a inserção de metodologias ativas de ensino, tendo em vista a limitação do modelo tradicionalmente utilizado.
Emergência em ação: um relato impactante sobre a importância vital da medicina de emergência no cenário atual
Authors: Caixeta Júlia Luísa Campos , Freire Fernanda , Lima Maria Luiza Pozza , Mucci Mila , Silva Fábio Luis da
Published: November 2023

A Medicina de Emergência moderna tem raízes que começam na primeira guerra mundial, onde médicos militares reconheceram que a rapidez e a ordem do atendimento de soldados feridos tiveram grande impacto na sobrevivência, e assim foram desenvolvidos sistema de triagem e o conceito de atendimento de emergência. Posteriormente, esse sistema foi adotado dentro da medicina civil, com o desenvolvimento de ambulâncias e do sistema pré-hospitalar. Hoje, existem mais de 48 países no mundo onde a especialidade é reconhecida. No Brasil foi reconhecida como uma especialidade médica em 2015, apesar de já haver residências desta modalidade iniciadas anteriormente.
Associação do melanoma cutâneo metastático com o gene BRAF: uma revisão da literatura
Authors: Miele Monique , Mendes Mariana do Couto , Frota Myriam Victória Monteiro , Moreno Rafaela , Tefé-Silva Cristiane
Published: November 2023

O câncer de pele é responsável pela maioria das doenças malignas em todo o mundo, sendo principalmente dividido em neoplasias malignas da pele melanoma e não melanoma (LINARES; ZAKARIA; NIZRAN, 2015). Correspondendo a 30% de todos os tumores malignos no Brasil, o melanoma possui incidência crescente e comportamento agressivo (SANTOS; SOUZA, 2019). Além do fator ambiental, como a exposição a raios do espectro ultravioleta, existe uma associação com fatores predisponentes genéticos, que contribuem para evolução a um melanoma metastático (LEONARDI et al., 2018).
Análise da microbiota das mãos de estudantes de medicina de uma faculdade particular de Ribeirão Preto
Authors: Ferreira Júlia Garcia de Carvalho , Viganó Lucas Luis de Souza , Roque Luiz Felipe Moreira , Martins Renan Cozol , Reis Ulisses Ávila , Zoccal Karina Furlani
Published: November 2023

A microbiota da pele do ser humano é colonizada por, principalmente, bactérias e fungos. A microbiota das mãos é constituída pela microbiota residente e pela transitória, sendo oriunda das camadas mais profundas e superficiais, respectivamente, ambas representadas, do ponto de vista quantitativo, pela presença de bactérias (CUSTÓDIO et al., 2012). Dados da literatura demonstram que as mãos dos profissionais de saúde são consideradas as principais vias de disseminação de infecções dentro do ambiente hospitalar, visto que funcionam como reservatório bacteriano (CARVALHO et al., 2003), dado que já foram encontrados valores de 3,9x104 a 4,6x106 unidades formadoras de colônia (UFC)/cm3 (MUNDY, 2008).
Avaliação do ácido poliáltico derivado do óleo de copaíba sob atividade analgésica em modelo animal
Authors: Barbosa Nathália Del Vecchio França , Campo Vanessa Leiria , Silva Cristiane Tefé da , Zoccal Karina Furlani
Published: November 2023

A obtenção de efeitos benéficos com o uso de drogas de origem natural contribuiu para que a medicina popular e tradicional introduzisse fármacos à terapêutica moderna. O arsenal terapêutico atualmente disponível inclui medicamentos resultantes da purificação de extratos de origem vegetal e animal e de isolamento de seus princípios ativos (SOUSA et al., 2008). Nas últimas décadas, estudos têm demonstrado o efeito anti-inflamatório de diversos compostos naturais. Sabe-se que quase 80% da população mundial, principalmente países subdesenvolvidos, dependem do uso de plantas e seus metabólitos bioativos para cuidados de saúde (MBUNI et al., 2020).
Uso da inteligência artificial na cardiologia: uma revisão integrativa
Authors: Santos Joabe Miguel Ribeiro dos , Cunha Isabela Cristina Oliveira da , Oliveira Julia Alves de , Lima Filho Flavio de , Naia Carolina Vieira , Cunha Carlos Geraldo da
Published: November 2023

A Inteligência Artificial (IA) é o resultado da mescla de padrões complexos da matemática e da computação que favorece o aprimoramento de um conjunto de algoritmos que simulam o processo de inteligência humana (LOBO, 2018; DEY et al., 2019). Dessa forma, a IA apresenta sistemas que se assemelham a competência do ser humano ao identificar uma problemática, resolvê-la e sugerir resoluções (PRICE, 2018). Outro conceito de IA sugere que seria a elaboração de sistemas de computação inteligentes que permitem executar tarefas sem receber instruções de forma direta de humanos, a exemplo dos “robôs” (KWON et al., 2018). Isto posto, os “robôs” dispõe-se de uma programação computadorizada composta por movimentos e atividades, enquadrando-se desde o início na definição de IA. Com a utilização de distintos algoritmos e meios para tomar decisões, bem como elevadas quantidades de dados, os sistemas de IA são capazes de sugerir ações quando solicitadas (LOBO, 2018; DEY et al., 2019). O termo Aprendizado de Máquina (do inglês Machine Learning - ML) refere-se à possibilidade de “aprender”, sendo este fundamentado em um agrupamento de tarefas.
O uso da telemedicina no sistema único de saúde: o avanço da tecnologia
Authors: Cunha Isabela Cristina Oliveira da , Moreira Leonardo Caruba , Jesus Leticia Wendel Madeira de , Mores Bruno Teixeira Marcos , Santos Joabe Miguel Ribeiro dos , Cunha Carlos Geraldo da
Published: November 2023

A telemedicina consiste em um atendimento médico realizado por meio de tecnologias eletrônicas, como notebooks, celulares e tablets, cujo possui o objetivo de ampliar o acesso dos usuários aos serviços de saúde de qualidade (PACHITO et al., 2022). Consequentemente, o uso da telemedicina cresce progressivamente nos estados brasileiros desde 2017 quando foi criado a Estratégia de Saúde Digital para o Brasil 2020-2028 (ESD28), sendo introduzida a telemedicina no Sistema Único de Saúde (SUS).
The Influence Of Tiktok Live Video Streaming, Price Discounts, And Free Shipping On Purchase Decisions
Authors: Febriah Intan , Febriyantoro Mohamad Trio
Published: November 2023

This research is motivated by the trend of Tiktok during the COVID-19 pandemic. This trend can be used to overcome economic problems due to declining public purchasing power. The purpose of this study was to determine the effect of live video streaming on Tiktok, discounted prices, and free shipping on online purchasing decisions. The population of this study is Skintific product users in DKI Jakarta who buy products on the Tiktok live platform. The sampling method used was purposive sampling. The samples obtained were 114 respondents. Based on the results of this study it was found that Tiktok live video streaming and free shipping have a positive and significant effect on purchasing decisions. Meanwhile, price discounts have no effect on purchasing decisions. The results of this study can be used by related sellers as a consideration for increasing sales through increasing consumer purchasing decisions.
The Influence Of Tourist Facilities And Service Quality On Visitor Satisfaction At The “Dunia Fantasi (DUFAN) Taman Impian Jaya Ancol” Amusement Park
Authors: Septiana Hana , Febriyantoro Mohamad Trio
Published: November 2023

The purpose of this study was to determine and analyze the influence of tourist facilities and service quality as independent variables, while the variable visitor satisfaction is the dependent variable. The number of respondents used in this study was 112 respondents. The data used is primary data, and inanalyzing data using SPSS software. Things tested in SPSS are validity test, reliability test, classic assumption test (normality test, multicollinearity test, and heteroscedasticity test), multiple linear regression analysis, F test, and T test. The results showed that the variables of Tourism Facilities and Service Quality has a significant effect on visitor satisfaction at Dunia Fantasi, Taman Impian Jaya Ancol amusement park.
The Influence Of Leadership And Work Environment On Employee Performance Atma Jaya University
Authors: Apriliana Putri Salsabila , Febriyantoro Mohamad Trio
Published: November 2023

This study aims to determine the effect of leadership and work environment on employee performance at Atma Jaya University. This type of research uses qualitative research methods with 30 employees as research respondents. The sampling technique uses the google form and is tested for validity and reliability. This study uses multiple linear regression analysis using SPSS 23 software. The results of this study are that leadership has a positive but not significant effect on employee performance and work environment has a positive but not significant effect on employee performance.
Fish Bone of Distal Ileum: A Rare Misdiagnosis
Authors: Akbar Ismail , Hassan Rao Erbaz , Hussain Syed Aamer , Ali Zulfiqar , Khan Arif Ullah , Tanveer Shafiq
Published: November 2023

Fish bone ingestion is a common occurrence, and most cases are uneventful. However, in some cases, fish bones can cause perforation of the gastrointestinal tract. Even with the growing utilization of computerised tomography (CT) imaging and the Alvarado criteria application, the potential for misdiagnosing acute appendicitis persists.This case report describes a patient who presented with abdominal pain and vomiting after ingesting a fish bone. The patient was found to have a perforation of the distal ileum by the ingested fish bone during surgery, which was repaired primarily. The patient made a full recovery. This case report highlights the importance of considering fish bone ingestion in patients with abdominal pain. Early diagnosis and treatment are essential to prevent complications.
Presencia de distimia en adolescentes escolarizados de la Unidad Educativa Jorge Álvarez – Cantón de Pillarlo/Ecuador
Authors: López Romero Ana Elizabeth , Guachi Díaz Cristina Maricela , Alarcón Arias Mario Roberto , Jácome Medina María Fernanda , Murillo Albornoz Marlyng
Published: November 2023

Presencia de distimia en adolescentes escolarizados de la unidad educativa Jorge Álvarez – localizada en Cantón de Píllaro – Ecuador, es un tema de investigación enfocado en abordar una problemática poco estudiada en el medio académico pero muy evidente en la población escolar, especialmente en estudiantes adolescentes quienes, son mayormente propensos a padecer la patología psicológica, limitando su calidad de vida. Para el desarrollo de la investigación y posteriormente la escritura del actual artículo de investigación, fue necesario plantear el interrogante concerniente a indagar ¿existe presencia de distimia en adolescentes escolarizados de la unidad educativa Jorge Álvarez, localizada en Cantón de Píllaro – Ecuador? Consecuentemente, se planteó el objetivo general conducente a analizar la presencia de distimia en adolescentes escolarizados de la unidad educativa Jorge Álvarez, localizada en Cantón de Píllaro – Ecuador. Para obtener información precisa, se empleó la metodología cualitativa, con el tipo de investigación – acción de manera que se logró obtener hallazgos favorables para el análisis que permitió identificar la presencia de distimia en el contexto escolar. Ante ello, se considera pertinente que tanto la institución educativa como el cuerpo docente en el marco de su quehacer pedagógico, diseñan y emplean estrategias pedagógicas acordes para tratar de minimizar la problemática desde el ámbito escolar.
Principio de especialidad en los consejos para la igualdad intergeneracional
Authors: Reyes Paladines Manolo Joselito , Añazco Aguilar Alan Osvaldo
Published: November 2023

El presente trabajo de investigación tuvo como objetivo analizar la vulneración de derechos de las personas que pertenecen a los grupos de atención prioritaria particularmente a la niñez y adolescencia frente a la creación de los Consejos de Igualdad que cumplen funciones multicompetentes. La metodología utilizada tiene que ver con lo Dogmática: permitiendo investigar en el ordenamiento jurídico ecuatoriano sobre las los Consejos de Igualdad intergeneracional para saber con certeza, si los funcionarios cumplen con la garantía y de precautelar el cumplimiento y restitución de derechos de estos grupos de atención prioritaria, teniendo en cuenta que   en este Consejo de Igualdad actualmente se incluyó a jóvenes mujeres y adultos mayores. Se concluyó que, no se está dando respuesta en restitución de derechos a los grupos de atención prioritaria debido a la falta de especialidad para atender a estos sectores vulnerables y a la falta de entidades de atención ejecutoras de las medidas de protección dictadas para restituir derechos vulnerados
El Método Singapur en el desarrollo del aprendizaje de las matemáticas en el nivel de Educación Básica
Authors: Ulloa Menta José Luis , Arteaga Gualán María Raquel , Arteaga Gualán Fátima Fernanda , Martínez Solorzano Sandra Elizabeth , Solórzano Solórzano María Esther , Moreira Rivera Jhonny Miguel
Published: November 2023

Entre los retos que tienen los docentes al enseñar y obtener buenos resultados en el área de matemáticas es escoger el método adecuado, esto supone desistir de modelos tradicionales que enfatizan la memorización y procedimientos mecánicos que, en comparación, el Método de Singapur busca la formación y enseñanza de las matemáticas desde otra perspectiva, favoreciendo el desarrollo de habilidades en los estudiantes. La presente investigación tuvo como finalidad de explorar aspectos relacionados con el Método Singapur en el desarrollo del aprendizaje de las matemáticas en el nivel de Educación Básica. La metodología se desarrolló bajo el enfoque cualitativo, basado en una revisión bibliográfica en el que se utilizó el software de Covidence sujeto a las directrices del Prisma 2020 que fue útil para revisar y extraer hallazgos precedentes, actuales y relevantes. Se concluye que, implementar el Método de Singapur produce efectos positivos en la enseñanza de las matemáticas, su eje central es la resolución de problemas para enfrentar los desafíos dentro y fuera del aula, pero para ello, en primer lugar, busca desarrollar competencias matemáticas mediante actividades que respondan al objetivo y que involucren las fases propuestas: concreta, pictórica y abstracta, cada una acompañada de recursos apropiados.
Pengaruh Persepsi Harga dan Kualitas Pelayanan Terhadap Loyalitas Pelanggan Melalui Kepuasan Pelanggan di Pintu Dua Coffee TMII
Authors: Ramadhani Wahyu Ari , Prawoto Prawoto
Published: November 2023

Tujuan Penelitian ini untuk analisis pengaruh persepsi harga dan kualitas pelayanan terhadap Loyalitas pelanggan melalui Kepuasan pelanggan baik secara langsung maupun tidak langsung dalam konteks usaha yang bergerak dibidang kedai kopi. Instrumen dikembangkan dengan menggunakan skala Likert. Responden sebesar 100 orang pelanggan dan 30 responden untuk uji validitas dan reliabilitas. Penelitian ini menggunakan metode kuantitatif, dengan menggunakan Path analysis. Hasil penelitian ini menunjukkan pengaruh langsung variabel persepsi harga, kualitas pelayanan dan Kepuasan pelanggan berpengaruh signifikan terhadap variabel Loyalitas Pelanggan. Pengaruh tidak langsung variabel persepsi harga tidak mempengaruhi secara signifikan Loyalitas Pelanggan melalui Kepuasan Pelanggan. Tetapi variabel kualitas pelayanan mempengaruhi loyalitas pelanggan melalui kepuasan pelanggan secara signifikan.
Recent updates on langya virus
Authors: Gangwar Ruby , Kumar Arvind , Zargar Abrar Ahmed , Kumar Hardik , Sharma Amit , Kumar Ranjeet
Published: November 2023

In this review, we discussed about the recent outbreak of langya virus (layV). After the major viral outbreak of Covid-19, a newly identified layV was first identified in northeastern provinces of Shandong and Henan in 2018, it, also known as langya henipavirus, belongs to the Paramyxoviridae virus family of single-stranded ribonucleic acid (RNA) viruses that cause different types of viral infections. From 2018 to 2022, a total of 35 reported incidents were either farmers or workers in factories and it was potentially the pathogens in 26 patients. Transmission of the virus is likely to occur from animals to humans. The presence of the virus and its RNA was identified mostly in shrews, indicating that shrews are the virus’s natural reservoir. The information was gathered from Google Scholar, PubMed, ResearchGate, World Health Organization (WHO) website, and other web pages from October 2022 to January 2023. The main aim of this study is to provide current information and awareness about layV to society, health-care professionals, researchers, and academicians on this disease, etc. If people are aware of this disease, then they can handle and prevent themselves. For the prevention for this disease, we include all the relevant information about layV symptoms, prevention, etiology, transmission, epidemiology, and treatment according to the WHO. This paper is helpful for future point of view because if on one takes it seriously then may be in the future, it will become a severe outbreak like Covid-19. In a world where outbreaks like COVID-19 and monkeypox occur, we must keep an eye out for developing infectious diseases like layV.
Wertveränderungen in der Abgeltungsteuer
Authors: Altmann Florian
Published: November 2023

The taxation of capital gains and losses has occupied the courts since the introduction of the „Abgeltungsteuer“. On the basis of a systematic analysis of income from capital assets, it is proven that section 20 (2) EStG intents the taxation of all realized capital gains and losses. This finding is confirmed by the relationship to the - constitutionally questionable - special loss offset restrictions. In particular, however, the offsetting restriction for total losses also creates new discrepancies between section 20 (2) EStG and the offsetting of losses. In order to eliminate the discrepancies as well as the revealed weaknesses of section 20 (2) EStG, an addition to the disposal surrogates is proposed.
Interstate Assistance to the Use of Force
Authors: Nußberger Benjamin K.
Published: November 2023

Whenever States use force in their international relations, interstate assistance is a vital component. The book clarifies the regulation of interstate assistance to a use of force under international law. It comprehensively reviews the relevant practice of States in United Nations resolutions, in international treaties and in more than 25 armed conflicts - from the Korean War to the current Ukraine war. It situates the regulation within the historic development of the ius contra bellum and contextualizes it with general rules of international law on complicity. Thereby, the book also sheds light on ambiguities of the regulation, thus providing the basis for more transparency and explicit discourse among both practitioners and scholars.
[Platone], Erissia
Authors: Donato Marco
Published: November 2023

This book provides a new critical edition of the Eryxias, an often neglected dialogue concerning the relationship between wealth and virtue transmitted into Plato’s corpus, but probably written in the Ancient Academy after the founder’s death. This new edition, which is founded on a complete revision of the manuscript tradition, is accompanied by an Italian translation, a complete introduction and a detailed commentary, examining the philological, literary and philosophical aspects of the text.
Motivation und Arbeitszufriedenheit
Authors: Ziegler Michaela
Published: November 2023

Due to demographic change, almost one third of the teachers in Austria are in the 55+ age group. This group is therefore of great and relevant importance in the school system. For this reason, the focus is on motivation factors and job satisfaction of teachers at Viennese compulsory schools who are older than 55. The aim of this scientific work is to find out which and how these positive factors can be used beneficially for the school system and subsequently transferred into everyday school life. At the same time, it will be investigated in which form the teacher training colleges can support personal motivation processes through further education and training.
Der Islam als akademische Praxis
Authors: Dreier Lena
Published: November 2023

The subject Islamic theology, which was founded eleven years ago, was politically expected to train imams who promote integration. The author empirically investigates how students of Islamic theology deal with these expectations. The book shows that the actors' attributions of meaning is interwoven with the state's approach to religion and the academic discipline's approach to Islam. The result is the concept of biographical Islamicity, i.e. a central mode of experience of Muslims in minority contexts. The actors institutionalise the image of a plural Islam. The book provides a sociological contribution to the discussions about religious-secular constellations in the society.
The Role of Statins in ASCVD
Authors: Lu Cong , Fang Lu , Zhu Yujie , Zheng Lemin , Liu Donghui
Published: November 2023

Statins are comprehensive lipid-lowering agents, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. As an effective cholesterol-lowering drug, statins inhibit a key step in the cholesterol biosynthesis pathway and have made outstanding contributions to the prevention and treatment of atherosclerotic cardiovascular disease (ASCVD). The mechanism is to competitively inhibit the endogenous cholesterol synthesis rate-limiting enzyme HMG-CoA reductase, block the intracellular hydroxy valerate metabolic pathway, and reduce intracellular cholesterol synthesis. Additionally, these actions also increase the number and activity of low-density lipoprotein (LDL) receptors on the cell membrane surface and promote plasma cholesterol clearance. Therefore, statins can reduce total cholesterol and LDL levels and reduce triglycerides (TG) to a certain extent and increase high-density lipoprotein (HDL). In addition to lipid regulation, statins may also treat ASCVD by improving endothelial function, Inhibiting inflammation, and stabilizing atherosclerotic plaque. This review summarizes the fundamental roles of statins in ASCVD.
Developing The Strategy for Steel Sales by Scenario Planning Approach
Authors: Hamonangan Simatupang Tumpal , Sunitiyoso Yos
Published: November 2023

The steel industry, often regarded as the mother of industry, holds a pivotal role in fostering national economic independence and supporting vital infrastructure projects. In Indonesia, the development of the steel industry stands as a key indicator of industrial advancement. However, the landscape has evolved dramatically, with escalating competition not just from PT Krakatau Steel but also from numerous emerging competitors producing similar products. This dynamic situation demands an aggressive sales strategy to secure market dominance, especially given the challenges posed by both local and international competitors. Addressing this, PT Krakatau Steel faces the essential question of how to optimize steel sales, approaching or even matching the plant's installed capacity, amidst this competitive environment. The solution lies in proactive strategic planning, which involves a meticulous analysis of both external and internal factors. Recognizing the need for foresight, the company has employed scenario planning, envisioning potential futures for the steel industry. By considering variables like raw material prices and government policies, four scenarios emerged: Armageddon, The King, The King's Speech, and Cast Away. Each scenario prompts a specific set of strategies and actions. Moreover, the company has established early warning systems to discern which scenario might unfold, enabling timely and precise responses. This forward-thinking approach culminated in a comprehensive strategic plan designed to guide PT Krakatau Steel through the complexities and uncertainties of the business landscape over the next seven years.
NPK Fertilizer Test and Plant Population on The Growth And Years of Sorgum (Sorghum bicolor (L.) Moench)
Authors: Triyono Kharis , Priyono Priyono , Agustina Wahyu
Published: November 2023

This study aims to determine the effect of NPK fertilizer dose and plant population on the growth and yield of Sorghum (Sorghum bicolor (L.) Moench).The design that was carried out was a Complete Randomized Block Design (RAKL) Factorial consisting of  NPK fertilizer dose treatment with four levels and the second-factor Spacing with two levels, so there are eight treatment combinations repeated four times. The data obtained were analyzed by analysis of variance and to find out significant differences continued with Duncan's Multiple Range Test with a significant level of 5%. The results showed that the fertilizer dose treatment had a significant effect on plant height and seed weight per panicle, the plant population treatment had no significant effect on all observed parameters, and the combination of fertilizer dose and population treatments had no significant effect on all observed parameters. The treatment with a fertilizer dose of 300 kg/ha produced the highest seed weight per panicle of 91.79 gr, and the lowest fertilizer dose of 150 kg/ha produced a seed weight per panicle of 71.95 gr.
COVID-19 Update: New Novavax Vaccine Formulation for 2023-2024
Authors:   Editors from The Medical Letter
Published: November 2023

A new 2023-2024 formulation of the adjuvanted protein subunit COVID-19 vaccine manufactured by Novavax that was developed to more closely target currently circulating SARS-CoV-2 variants has been made available in the US under an FDA Emergency Use Authorization (EUA) for use in persons ≥12 years old. The original formulation of the Novavax vaccine is no longer authorized for use in the US. In September, updated formulations of the mRNA COVID-19 vaccines manufactured by Pfizer/BioNTech (Comirnaty) and Moderna (Spikevax) were licensed by the FDA for use in persons ≥12 years old and made available under EUAs for use in persons 6 months to 11 years old.
Comparison Chart: Antiviral Drugs for Influenza for 2023-2024
Authors:   Editors from The Medical Letter
Published: November 2023

Comparison chart of antiviral drugs for influenza for 2023-2024.
Etrasimod (Velsipity) for Ulcerative Colitis
Authors:   Editors from The Medical Letter
Published: November 2023

The oral sphingosine 1-phosphate (S1P) receptor modulator etrasimod (Velsipity – Pfizer) has been approved by the FDA for treatment of moderately to severely active ulcerative colitis in adults. It is the second oral S1P receptor modulator to be approved in the US for this indication; ozanimod (Zeposia) was the first.
Perancangan Pembangkit Listrik Tenaga Surya (PLTS) Sebagai Sumber Energi Listrik Untuk Akuaponik
Authors: Chandra Yudi
Published: November 2023

Semakin tinggi angka pertumbuhan penduduk semakin besar kebutuhan energi listrik yang diperlukan. Selain itu, bertambahnya jumlah penduduk mengakibatkan banyak terjadinya pengalihan fungsi lahan dari untuk pertanian menjadi non pertanian ataupun dari lahan pertenakan menjadi non pertenakan. Oleh karena itu, cara untuk mengatasi kekurangan akan ketahanan pangan dan ramah lingkungan yaitu dengan sistem akuaponik. Akuaponik tidak terlepas dari sirkulasi air, yang mana air ini merupakan kebutuhan utama baik untuk ikan maupun tanaman tersebut. Pompa air merupakan penggerak air yang digerakkan oleh energi listrik. Permasalahan yaitu, karena air yang digunakan baik untuk tumbuhan maupun ikan marupakan bahan utama maka air tersebut maka harus mengalir dan jika listrik padam atau terdapat gangguan lain pada listrik maka proses pengaliran air tersebut akan terhenti, selain hal tersebut untuk mengurangi ketergantungan akan energi listrik dari PLN salah satu upaya yang dapat dilakukan yaitu dengan memanfaat energi alternatif yaitu menggunakan energi cahaya matahari menjadi energi listrik atau disebut dengan PLTS. Pada Perancangan PLTS ini dilakukan dengan melakukan perhitungan terhadap komponen-komponen PLTS yang diperlukan, Setelah itu menentukan tempat peletakan panel surya yang digunakan. Setelah mengetahui spesifikasi dari komponen-komponen, kemudian baru bisa melakukan perhitungan untuk Rancangan Anggaran Biaya (RAB) yang akan direkomendasikan dalam perancangan PLTS ini. Hasil perancangan PLTS ini yaitu menggunakan komponen berupa panel surya, solar charge controller, aki dan inverter. Setelah melakukan perhitungan terhadap beban pada akuaponik maka pada perancangan ini didapatlah komponen- komponen yaitu panel surya berkapasitas 150 Wp sebanyak 1 buah, aki berkapasitas 70 Ah 12 Volt sebanyak 1 buah, inverter kapasitas 500 watt sebanyak 1 buah dan SCC berkapasitas 10 A sebanyak 1 buah. Biaya yang direkomendasikan sebesar Rp. 3.500.000,00 untuk PLTS tersebut.
The Effect Of Cooperative Integrated Reading And Composition (Circ) Technique On Reading Comprehension Of Narrative Text At Grade Eighth Students Of SMP Swasta GKPS 3 Pematang Siantar
Authors: Kesia Rahelin Simanjuntak  , Dumaris E Silalahi  , Yanti Kristina Sinaga
Published: November 2023

This research aimed to find Out The Effect Of Cooperative Integrated Reading And Composition (Circ) Technique On Reading Comprehension Of Narrative Text At Grade Eighth Students Of Smp Swasta Gkps 3 Pematang Siantar. This research design is quantitative. The quantitative method is a planned and careful problems solving method. In quantitative, systematically control data collection design, and will focus on constructing inductively concluded theories within the framework of empirically proving hypothesis. The quantitative research imposes objective measuring to collect numeric data that are utilized the answers of questions or test the specified hypothesis. Researcher will choose two groups as the sample, namely class VIII.1 and VIII.2.  The two classes that researcher will choose as sample have studied the narrative text based on school education curriculum. By calculating the data, we can conclude that the t-test result (2.42) exceeded the t-table value at a significance level of 0.05 (2.00), meaning 2.42 > 2.00. This indicates that the use of the CIRC technique has a significant impact on students' reading comprehension. This is evident from the list of student scores in reading comprehension when using the CIRC technique compared to the conventional technique. In other words, grade eighth students' capacity at SMP Swasta GKPS 3 Pematang Siantar in reading comprehension is significantly impacted by using of CIRC technique.
Ecosystem services for crop protection in bean fields in Moshi rural, along the slopes of Mt. Kilimanjaro Northern Tanzania
Authors:   , Ndakidemi Baltazar
Published: November 2023

The natural ecosystem, in and around bean fields potentially offer beneficial services that assist bean productivity. This study was conducted to investigate the distribution of beneficial invertebrates and plants and their conducive environmental conditions in bean fields in Moshi rural, along the slopes of Mt. Kilimanjaro Northern Tanzania. Four farms were chosen on the basis of four factors which were elevation, crop diversity (mixed crop farming), forestation level (farming in grasslands, woodlands and bush land areas), and cropping intensity (most land converted to farming with little bush land, farm-fallow mosaic, small areas of farming with mostly bush/fallow land). Beneficial insects were collected monthly using pan traps. Five traps were placed in the crop plants and the other five traps were placed in the field margin. The insects collected were identified to the functional group level. Plants found associated with beneficial insects were also collected for identification. Monitoring of the insects’ visits to plants was done and photos were taken. It was observed that elevation, time of the year (month), field margin plant species, rainfall and temperature affected the type, richness and diversity of invertebrate communities. There are great spatio-temporal differences in invertebrates’ groups associated with ecosystems services delivery, particularly pollination and pest management functions. The results indicated that there was significant difference (P ≤ .05) among sites in terms of the abundance and richness of invertebrates present. Rainfall and temperature had a potential influence on invertebrates’ groups. In most cases, the highest populations of insects were found in the field margins and edges (P ≤ .05). From this study it can be recommend that it is essential to preserve field margins and edges, cultivate plant species that attract beneficial insects and devise agro-environment strategies to support them.
Risk of heavy metals exposure through consumption of rice from Kahama and Geita districts
Authors:   , Simon Fides
Published: November 2023

Heavy metals exposure is associated with various human health problems. This research aimed at determining the levels of heavy metals in paddy soils and in polished rice from villages around the artisanal gold mining areas in Kahama and Geita districts. It also intended to assess the risk of human exposures of heavy metals through rice consumption around the artisanal gold mining areas in Kahama and Geita districts, Tanzania. Twenty soil samples were collected from paddy fields and 20 polished rice samples grown from those fields were taken from the farmers. An additional 20 polished rice samples were collected from farmers in other villages from the same districts. Information about rice cultivation practices and rice consumption were collected from 40 farmers that were randomly selected, 20 from each of the two districts; Kahama and Geita districts, in which the mining areas are located. Chromium (Cr), copper (Cu), zinc (Zn), Mercury (Hg), cadmium (Cd), nickel (Ni), lead (Pb) and arsenic (As) were determined in the soil and rice samples using Energy Dispersive X–ray Florescence spectrometer. Heavy metals exposure through rice consumption, for each of the forty farmers, was determined using deterministic approach. In all the soil samples, concentrations of Cd and Cr were found to be above the maximum limits of 1 mg/kg and 100 mg/kg, respectively, as set by Tanzania Bureau of Standards (TBS). Concentrations of Pb and Cd in all the rice samples were above the maximum limits set by Codex Alimentarius Commission. Forty percent of the farmers consumed rice at least once daily with per capita consumption of 66.8 g per day for Geita district and 74.0 g per day for Kahama district. According to Joint FAO/WHO Expert Committee on Food Additives (JECFA), the estimated daily intake (EDI) for Cd was found to be above tolerable daily intake (TDI) for 95% of all population in both Kahama and Geita districts while the estimated daily intakes (EDIs) for As, Zn and Cu in both Kahama and Geita population were below the TDIs. The results also showed that sites which are closer to the mining activities had higher heavy metal concentration in both rice and soils compared to the sites further away from the mining activity.
Fiscal Policy Analysis Bekasi District 2021 Fiscal Year
Authors: Susantie Firdhawati , Ferizaldi Ferizaldi
Published: November 2023

This study aims to analyze the fiscal policy implemented by the Bekasi Regency local government. The goal is to improve the financial structure by increasing regional financial capacity, which ultimately creates a positive fiscal gap as an indicator of policy success. This study used a qualitative literature review approach, where data was gathered through observations, literature study, and the examination of various secondary sources. The collected data was then analyzed using a descriptive model, which involves describing the data as it is without any alterations or modifications. The findings revealed that the Bekasi Regency Government has put in place various measures to achieve a positive fiscal gap. These include Extensification, which involves maximizing Regional Original Revenue (PAD), and Intensification, where the Tax Object Sale Value (NJOP) is adjusted to optimize the revenue from Fees for the Acquisition of Rights on Land/Building (BPHTB).
Incidence of Prediabetes and its Development Risk Factors among Bachelor Students at Kampala International University's Western Campus in Uganda
Authors:   Faculty of Clinical Medicine and Dentistry Kampala International University Western Campus Uganda., Michael Kavubu
Published: November 2023

Prediabetes marks blood glucose levels above normal yet below the diabetes threshold. Its prevalence is escalating worldwide, with projections estimating over 470 million affected individuals by 2030. Notably, there is a dearth of studies offering insight into prediabetes prevalence among university students in Uganda. This research was designed to assess prediabetes prevalence and associated risk factors among apparently healthy Kampala International University Western Campus (KIU-WC) bachelor students. Employing a prospective cross-sectional study design, the investigation involved structured selfadministered questionnaires, anthropometric measurements, and blood biochemistry, targeting registered university students of all ages at KIU-WC. Sample size calculations were based on a formula, with BMI for age and sex referenced against Agarwal charts. Fasting blood glucose (FBG) levels were classified per ADA criteria. A total of 121 students (61.2% male, 38.8% female) aged 15-35 participated. Results indicated a significant prediabetes prevalence of 19.8%. Notably, prediabetes rates varied among distinct age groups, particularly higher among middle-aged or young adults (18-25 years). The study underscores lifestyle modifications as pivotal in preventing or delaying prediabetes progression to Type 2 Diabetes Mellitus (T2DM). Moreover, it highlights the necessity for further comprehensive prospective studies with larger sample sizes and adequate funding to precisely quantify prediabetes burden, its risk factors, complications, preventive measures, and validate the epidemiological findings observed in this investigation. Keywords: Diabetes, Prediabetes, Lifestyle modification, Hypertension, Obesity.
The mechanism of Michael 1,4-Nucleophilic addition: a computationally derived reaction pathway.
Authors: Rzepa Henry
Published: November 2023

In 2013, I created an iTunesU library of 115 mechanistic types in organic and organometallic chemistry, illustrated using video animations of the intrinsic reaction coordinate (IRC) computed using a high level quantum mechanical procedure. Many of those examples first derived from posts here. That collection is still available and is viewable in the iTunesU app on an iPhone or an iPad.
Catalytic Mitsunobu reaction.
Authors: Rzepa Henry
Published: November 2023

If, as a synthetic chemist, you want to invert the configuration of an alcohol in which the OH group is at a chiral centre, then the Mitsunobu reaction has been a stalwart for many years. Now a catalytic version has been published, [1] along with a proposed mechanism.
I’m stupid
Authors: Taylor Mike
Published: November 2023

Earlier this evening, while I was editing an SV-POW! article that we plan to release on Wednesday, I (Mike) inadvertently hit the  Publish  button rather than  Save Draft  as I’d intended.  I was able to quickly undo the posting, but it’s possible that some of you may have seen Wednesday’s article prematurely, especially if you use an RSS reader that happened to cache that page during the brief period that it was available.
I do not dare behold it
Authors: Taylor Mike
Published: November 2023

By a curious coincidence, today’s  Bob The Angry Flower  cartoon is all about the Archbishop description. Enjoy. But, hey, at least I got my confession in early — I was officially the first participant to fail the 2010 Paleo Project Challenge. THIS year, for sure!
Tutorial 13: how to dissect a neck
Authors: Taylor Mike
Published: November 2023

This tutorial is based on all the things that I stupidly forgot to do along the way of tearing down the juvenile giraffe neck that Darren, John Conway and I recently got to take to pieces.  At half a dozen different points in that process, I found myself thinking “Oh, we should have done  X  earlier on!”  So it’s not a tutorial founded on the idea that I know how this should be done;
The Kekulé vibration as a function of aromatic ring size. A different perspective using lemniscular rings.
Authors: Rzepa Henry
Published: November 2023

In the previous posts, I tried to track down the onset of bond length alternation (  BLA  ) as a function of ring size in aromatic cyclocarbons, finding the answer varied dramatically depending on the type of method used to calculate it. So here I change the system to an unusual kind of aromatic ring, the  leminiscular  or  figure-eight  annulene series.  ♥  I explore the Kekulé vibration for such species
Diatomics with eight valence-electrons: formation by radioactive decay.
Authors: Rzepa Henry
Published: November 2023

This is a follow up to my earlier post about C⩸N  +  , itself inspired by this ChemRxiv pre-print[1] which describes a chemical synthesis of singlet biradicaloid C  2  and its proposed identification as such by chemical trapping.
Anyone have print coverage of Brontomerus?
Authors: Taylor Mike
Published: November 2023

Matt or I will probably post properly later today, but I just wanted to post a quick note to ask whether anyone has any printed (as opposed to online) newspaper copy on  Brontomerus  ?
Cyclo[6] and [10]carbon. The Kekulé vibrations compared.
Authors: Rzepa Henry
Published: November 2023

In the previous post, I looked at the so-called Kekulé vibration of cyclo[18]carbon using various quantum methods and basis sets. Because some of these procedures can take a very long time, I could not compare them using the same high-quality consistent atom basis set for the carbon (Def2-TZVPP). Here I try to start to do this using the smaller six and ten carbon rings to see what trends might emerge.
Onward!
Authors: Wedel Matt
Published: November 2023

Sinclair brontosaur, Hennessey, Oklahoma. This one has cement shoes because some ne’er-do-wells ganked the old one in the middle of the night a couple of years ago.
New generations of globally aggregating search engines – for (chemical) data.
Authors: Rzepa Henry
Published: November 2023

Chemists have long been familiar with search engines that aspire to index a large proportion of the chemical literature.
Wem gehört das Geld der VG Wort?
Authors: Michal Wolfgang
Published: November 2023

Nach jahrelangem Rechtsstreit hat der Bundesgerichtshof ein klares Urteil zugunsten der Urheber gefällt. Sie müssen ihre schmalen Tantiemen nicht mehr mit den Verlagen teilen. Warum sollten sie auch?  Nehmen wir einmal an, die Mieter eines Landes würden eine Verwertungsgesellschaft gründen. Aufgabe dieser Gesellschaft wäre es, alle Möbelstücke, die von Mietern bei ihrem Auszug zurückgelassen werden, weiter zu verwerten.
Airy Area: approximating surface area of a cell from a 3D point set
Authors: Royle Stephen
Published: November 2023

In the spirit of “if it took you a while to find out how to do something, write about it”, I will detail a method to approximate the surface area of a 3D shape. Our application here was finding the surface area of a cell but it can be used on any shape. We start with a 3D point set, specified by points of interest in a single cell imaged by 3D confocal microscopy.
What effect do explicit solvent molecules have on calculated optical rotation: D-(“+”)-Glyceraldehyde.
Authors: Rzepa Henry
Published: November 2023

In this series of posts on optical rotations, I firstly noted Kirkwood’s 1937 attempt to correlate the optical rotation of butan-2-ol with its absolute configuration.
The singlet and open shell higher-spin states of [4], [6] and [8]-annulenes and their Kekulé vibrational modes
Authors: Rzepa Henry
Published: November 2023

In 2001, Shaik and co-workers published the first of several famous review articles on the topic  A Different Story of π-Delocalization. 
Sauropods stomping theropods, redux
Authors: Taylor Mike
Published: November 2023

A month ago, I posted an article containing all the examples known to me of that sadly neglected palaeo-art theme, Sauropods Stomping Theropods: Mark Hallet’s  Jobaria  squishing  Afrovenator  , Luis Rey’s  Astrodon  biting/carrying a raptor, Mark Witton’s  Camarasaurus  grinding juvenile theropods to dust, and of course Francisco Gascó’s and Emily Willoughby’s  Brontomerus  pieces, both of them showing Bronto
Comment on “Resolving the Quadruple Bonding Conundrum in C2 Using Insights Derived from Excited State Potential Energy Surfaces”: The 7Σ heptet excited states for related molecules.
Authors: Rzepa Henry
Published: November 2023

I noted in an earlier blog, a potential (if difficult) experimental test of the properties of the singlet state of dicarbon, C  2  . Now, just a few days ago, a ChemRxiv article has been published suggesting another (probably much more realistic) test.[1] This looks at the so-called  7  Σ open shell state of the molecule where three electrons from one σ and two π orbitals are excited into the corresponding σ  *  and