bluuebunny/crossref_metadata_2025 huggingface dataset:
Nivel de conocimientos y su relación con las actitudes y prácticas preventivas del Zika
Authors: Yupari-Azabache Irma , Benites Santiago M. , Otiniano Nélida Milly , Aguilar Ch Pablo , Romero Cecilia V. , Sergent Shane
Published: November 2018

Objetivo. Este estudio descriptivo correlacional de corte transversal; se realizó para determinar el nivel de conocimientos y su relación con las actitudes y prácticas preventivas del Zika en el distrito de Chepen - La Libertad Perú. 2017. Materiales y métodos. Se aplicó un cuestionario sobre conocimiento, actitudes y prácticas preventivas en una muestra de 284 personas adultas, con una edad promedio de 37 años. Resultados. Los resultados demuestran que el nivel de conocimiento general sobre zika fue regular en un 79% y bueno en un 21%. En cuanto a las prácticas preventivas de zika más comunes que realizan los habitantes de Chepén, un 83% mencionan que lavan frecuentemente los depósitos de agua, 77% usan cepillo y detergente para lavar los depósitos con agua y 75% coloca una tapa sobre los depósitos con agua. Conclusiones. El nivel de conocimiento tiene una relación significativa con las practicas preventivas del zika (p<0.05). Además, el nivel de conocimiento regular constituye un factor de riesgo (OR: 5, IC: 2.073-10.063) para la inadecuada practica preventiva del zika, siendo que las personas con un nivel de conocimiento regular tienen 5 veces mayor probabilidad de tener prácticas preventivas inadecuadas. Sin embargo el nivel de conocimiento no tiene una relación significativa con las actitudes hacia la prevención del zika (p>0.05).
Caracterización molecular de Cryptococcus neoformans recuperado de guano de palomas en Rivera y Neiva, Colombia
Authors: Camila Virviescas B  , María Aragón  , Fabiola González C  , Patricia Escandón H  , Hans Castro S  , Luis Reinel Vasquez
Published: November 2018

Objetivo. Caracterizar fenotípica y genotípicamente aislados de Cryptococcus neoformans y Cryptococcus gattii presentes en heces de palomas (Columba livia) y en suelo, hojas y detritos de árboles de almendro (Terminalia catappa) en los municipios de Neiva y Rivera, Colombia. Materiales y métodos. Ciento dieciocho muestras fueron recogidas en 13 zonas caracterizadas por la presencia de árboles de almendro y alta densidad de palomas, entre enero y junio de 2016. La incubación de las muestras procesadas se hizo a 27°C durante dos semanas en agar Guizottia abyssinica. La caracterización fenotípica, la determinación de la especie y la posterior tipificación molecular se hizo mediante PCR huella digital con el iniciador (GTG)5 y Polimorfismos de Longitud de Fragmentos de Restricción empleando los iniciadores URA5 y SJ01. Resultados. Un 5.9% de las muestras de heces de palomas fueron positivas para C. neoformans var grubii (patrón molecular VNI). Las muestras recolectadas a partir de almendros no fueron positivas para ninguna de las dos especies estudiadas. Conclusiones. El aislamiento de C. neoformans de heces de palomas (Columba livia) en los municipios de Rivera y Neiva aporta al escaso conocimiento que se tienen acerca de este patógeno en el departamento del Huila, revelando la importancia de continuar con estos estudios, no solo en el ambiente sino en la población expuesta.
Rehabilitation, the Great Absentee of Virtual Coaching in Medical Care: Scoping Review (Preprint)
Authors: Tropea Peppino , Schlieter Hannes , Sterpi Irma , Judica Elda , Gand Kai , Caprino Massimo , Gabilondo Inigo , Gomez-Esteban Juan Carlos , Busnatu Stefan , Sinescu Crina , Kyriazakos Sofoklis , Anwar Sadia , Corbo Massimo
Published: November 2018

BACKGROUND

In the last few years, several studies have focused on describing and understanding how virtual coaches (ie, coaching program or smart device aiming to provide coaching support through a variety of application contexts) could be key drivers for health promotion in home care settings. As there has been enormous technological progress in the field of artificial intelligence and data processing in the past decade, the use of virtual coaches gains an augmented attention in the considerations of medical innovations.

OBJECTIVE

This scoping review aimed at providing an overview of the applications of a virtual coach in the clinical field. In particular, the review focused on the papers that provide tangible information for coaching activities with an active implication for engaging and guiding patients who have an ongoing plan of care.

METHODS

We aimed to investigate the use of the term virtual coach in the clinical field performing a methodical review of the relevant literature indexed on PubMed, Scopus, and Embase databases to find virtual coach papers focused on specific activities dealing with clinical or medical contexts, excluding those aimed at surgical settings or electronic learning purposes.

RESULTS

After a careful revision of the inclusion and exclusion criteria, 46 records were selected for the full-text review. Most of the identified articles directly or indirectly addressed the topic of physical activity. Some papers were focused on the use of virtual coaching (VC) to manage overweight or nutritional issues. Other papers dealt with technological interfaces to facilitate interactions with patients suffering from different chronic clinical conditions such as heart failure, chronic obstructive pulmonary disease, depression, and chronic pain.

CONCLUSIONS

Although physical activity is a healthy practice that is most encouraged by a virtual coach system, in the current scenario, rehabilitation is the great absentee. This paper gives an overview of the tangible applications of this tool in the medical field and may inspire new ideas for future research on VC.
Identifying Attrition Phases in Survey Data: Applicability and Assessment Study (Preprint)
Authors: Hochheimer Camille J , Sabo Roy T , Perera Robert A , Mukhopadhyay Nitai , Krist Alex H
Published: November 2018

BACKGROUND

Although Web-based questionnaires are an efficient, increasingly popular mode of data collection, their utility is often challenged by high participant dropout. Researchers can gain insight into potential causes of high participant dropout by analyzing the dropout patterns.

OBJECTIVE

This study proposed the application of and assessed the use of user-specified and existing hypothesis testing methods in a novel setting—survey dropout data—to identify phases of higher or lower survey dropout.

METHODS

First, we proposed the application of user-specified thresholds to identify abrupt differences in the dropout rate. Second, we proposed the application of 2 existing hypothesis testing methods to detect significant differences in participant dropout. We assessed these methods through a simulation study and through application to a case study, featuring a questionnaire addressing decision-making surrounding cancer screening.

RESULTS

The user-specified method set to a low threshold performed best at accurately detecting phases of high attrition in both the simulation study and test case application, although all proposed methods were too sensitive.

CONCLUSIONS

The user-specified method set to a low threshold correctly identified the attrition phases. Hypothesis testing methods, although sensitive at times, were unable to accurately identify the attrition phases. These results strengthen the case for further development of and research surrounding the science of attrition.
DEVELOPMENT OF AZITHROMYCIN LOADED LEMONGRASS OIL BASED MICROEMULSION AND DETERMINATION OF ANTIBACTERIAL POTENTIAL
Authors: Ebenazer Andrew , Franklyne Jonathan Sampath , Mukherjee Amitava , Chandrasekaran N.
Published: November 2018

Objective: Azithromycin (AZM), an azalide drug is used to treat bacterial infections. It is poorly water-soluble, with low human bioavailability due to partial absorption. This can be improved using a microemulsion drug delivery system using essential oil.Methods: Microemulsion system was prepared with AZM solubilized lemongrass oil (Cymbopogon citratus), Tween 20 and water containing 1% (v/v) 10 mmol sodium hydroxide. In vitro drug release was determined using a 14KDa semipermeable dialysis membrane. The kinetics of bacterial killing was done at MIC concentrations, and viable counts were determined hourly for 24 h. Bacterial cell viability was determined by differential staining with acridine orange and ethidium bromide. In vitro toxicity was determined by the MTT assay, while in vivo toxicity was determined in male Wistar rats.Results: The optimized formulation (5:20:75 %) was thermodynamically stable with drug solubility of 366.90 mg/ml and a droplet diameter of 12.4±3.9 nm, which do not show in vivo or in vitro toxicity. In vitro drug release study in simulated body fluids revealed a controlled drug release from microemulsion-based formulation. The MIC was 1μg/ml and 2μg/ml against Staphylococcus aureus and Escherichia coli respectively. In vitro kill kinetics showed>2 log10 killing by 8 h. Bacterial cell viability assay and scanning electron microscopy analysis further confirmed substantial morphological changes due to alteration in the cell membrane.Conclusion: The reduced droplet size and the inherent antibacterial property of lemongrass oil enhanced the efficacy of the AZM loaded ME system in comparison with the bulk drug, against the bacterial pathogens.
PREPARATION, CHARACTERIZATION, AND EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF ETORICOXIB LOADED SOLUPLUS® NANOCOMPOSITES
Authors: Pore Yogesh , Mane Madhuri , Mangrule Vaishnavi , Chopade Atul , Gajare Pankaj
Published: November 2018

Objective: The objective of this study was to prepare and characterize etoricoxib (ECB) loaded Soluplus® nanocomposites to improve its physicochemical properties. The effect of polymer and surfactant concentration on particle size, in vitro percentage dissolution efficiency and the anti-inflammatory activity of nanocomposites were also investigated.Methods: The nanocomposites were prepared by using a freeze-drying technique. The analytical evidence for the formulation of lyophilized nanocomposites in solid state were generated and confirmed by differential scanning calorimetry (DSC), fourier transformation infrared spectroscopy (FTIR), x-ray powder diffractometry (XPRD) and scanning electron microscopy (SEM). The in vitro drug release profile of nanocomposites was compared with pure ECB powder.Results: The nanocomposites of ECB were contained in a nano range with particle size and zeta potential of 63.5 nm and 46.5 mv, respectively. The solubility and dissolution of the nanocomposites were significantly (p<0.001) improved as compared to ECB alone, evidenced by decreased log P values (1.90±0.002) of the nanocomposites. The characterization studies revealed the formation of amorphous nanocomposites of ECB with existence of physical interactions between drug and polymer. The anti-inflammatory activity of nanocomposites evaluated by carrageenan-induced rat paw edema model demonstrated nonsignificant (p>0.05) increase in anti-inflammatory activity as compared to pure ECB.Conclusion: From the results, it could be concluded that the formation of ECB nanocomposites with Soluplus® could be an effective and alternative approach to modify the physicochemical properties of ECB.
PHARMACOKINETIC STUDIES OF A CHRONOTHERAPEUTIC DRUG DELIVERY SYSTEM OF LORNOXICAM BY LC-MS/MS METHOD
Authors: Abraham Sindhu , Deveswaran Rajamanickam , Anbu Jayaraman , Furtado Sharon , Srinivasan Bharath
Published: November 2018

Objective: The objective of this study was to investigate differences in pharmacokinetic patterns of immediate release tablet (IR) and compression coated tablet (CCT) of lornoxicam, proposed for the chronotherapeutic treatment of rheumatoid arthritis.Methods: The dosage forms were administered to two groups of white New Zealand rabbits (n=3), and the plasma drug levels were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Pharmacokinetic parameters like maximum concentration (Cmax), time is taken to reach maximum concentration (Tmax), area under the curve (AUC), elimination half-life (t1/2) and Mean Residence Time (MRT) were determined.Results: In the case of IR tablets, the drug was detected within 15 min after oral administration and a Cmax of 1269.57±4.04 ng/ml were attained at 2±0.15 h. With CCT, the drug was detected only after 5 h and a Cmax of 1279.24±12.76 ng/ml were attained at 8±0.10 h. The CCT showed maximum drug release at the eighth hour in comparison to IR tablet which showed maximum release at the second hour of study.Conclusion: The predominant lag time prior to drug release from CCT is an indication that it is consistent with the requirements of chronopharmaceutical drug delivery. The results suggest that the compression coated tablet is a promising approach for chronotherapeutic management of rheumatoid arthritis.
FORMULATION AND OPTIMIZATION OF FLOATING TABLETS OF CLOPIDOGREL BISULPHATE USING DESIGN OF EXPERIMENTS
Authors: Deshkar Sanjeevani S. , Pawara Arvind S. , Shirolkar Satish V.
Published: November 2018

Objective: The present study aimed at designing of floating matrix tablet of clopidogrel bisulphate by design of experiments.Methods: The tablets were prepared by direct compression technique using hydroxypropyl methylcellulose K15 (HPMC) as a matrix polymer and sodium bicarbonate as a gas generating agent. In order to optimize the concentration of HPMC (X1) and sodium bicarbonate (X2), a 32 full factorial design was employed. The tablet formulations were evaluated for floating lag time (Y1), floating or buoyancy time (Y2), percent water uptake, and differential scanning calorimetry (DSC) and in vitro drug release (Y3).Results: The formulation variables, HPMC concentration, and sodium bicarbonate concentration exerted a significant effect on floating behavior and drug release characteristics of the tablet. The optimized formulation, with 15% sodium bicarbonate concentration and 30 % HPMC concentration resulted in 5±2.6 sec of floating lag time, 22.0±0.6 h of floating time and 42.0±0.99% of clopidogrel bisulphate release in 8 h of dissolution study. The drug release mechanism was identified as nonfickian. The water uptake studies revealed that with an increase in HPMC concentration, there was an increase in swelling index of tablet whereas higher sodium bicarbonate concentration supported the faster erosion of matrix tablets. DSC study revealed no interaction of drug and polymers. The lower percentage error between predicted and observed responses of the optimized formulation validated the design.Conclusion: The study demonstrated successful designing of floating clopidogrel bisulphate tablet with factorial design.
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF CAFFEINE IN GREEN COFFEE BEANS (COFFEA ARABICA L.) FROM THREE DISTRICTS OF WEST JAVA, INDONESIA BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY
Authors: Saputri Febrina Amelia , Muchtaridi Muchtaridi
Published: November 2018

Objective: To develop and validate a simple, accurate, and precise HPLC method for the determination of caffeine in green coffee beans (Coffea arabica L.) from three districts of West Java, Indonesia.Methods: The analytical method was conducted using Enduro C-18 (250 x 4.6 mm) column with methanol: water (37: 63) as a mobile phase, the flow rate was 1.0 ml/min, and the detector wavelength was set at 274 nm. The selectivity, linearity, limit of detection (LOD), limit of quantification (LOQ), accuracy, precision, and system suitability testing were evaluated as the parameters of validation.Results: The retention time of caffeine was 6.36 min. % RSD for precision was 0.192. The linearity of the method was obtained using a concentration range of 1-200 ppm with the correlation coefficient of 0.998. The limit of detection was 9 ppm and the limit of quantitation was 28 ppm. The accuracy was in between 90.723%-102.853%. Caffeine levels from Garut, Pangalengan, and Tasikmalaya were 1.454 ± 0.004%, 1.574 ± 0.082%, and 2.280 ± 0.004%.Conclusion: The proposed HPLC method meets the acceptance criteria of validation parameters and can be applied for routine analysis.
RECENT UPDATE ON ORAL FILMS: A BENCH TO MARKET POTENTIAL
Authors: Tiwari Renuka R. , Umashankar Dr. M. S. , N. Damodharan
Published: November 2018

Oral films are gaining a lot of attention as a substitute approach to the conventional dosage form. Over the past few years, many of the pharmaceutical scientists throughout the world are focusing their research on oral films, trying to see the sights of oral films as a novel drug delivery system. The oral films are convenient to swallow for geriatric and pediatric patients, are self-administrable, used for systemic and local action and rapid release of a drug, which makes it an excellent system of drug delivery. This review article mainly discusses the manufacturing aspects of films and their characterization, applications and the constraints in the development of oral films along with highlights of market potential.
SYNTHESIS, CHARACTERIZATION AND EVALUATION OF STARCH XANTHATE AS A SUPERDISINTEGRANT IN THE FORMULATION OF FAST DISSOLVING TABLETS
Authors: Rada Santosh Kumar , Naga T.
Published: November 2018

Objective: To synthesize, characterize and evaluate starch xanthate as a superdisintegrant in the formulation of fast dissolving tablets by employing 23 factorial design.Methods: Starch xanthate was synthesized by gelatinization process. The physical and micromeritic properties were performed to evaluate the synthesized starch xanthate. The fast dissolving tablet of ibuprofen was prepared by employing starch xanthate as a superdisintegrant in different proportions in each case by direct compression method using 23 factorial design. The drug content, hardness, friability, disintegration time and other dissolution characteristics like percent dissolved in 5 min (PD5), dissolution efficiency in 5 min (DE5%) and first order rate constant (K1) were used in the evaluation of prepared fast dissolving tablets.Results: The starch xanthate prepared was found to be fine, free flowing slightly crystalline powder. Starch xanthate exhibited good swelling in water. The study between ibuprofen and starch xanthate was shown the absence of interaction by fourier transform infrared spectra (FTIR) and differential scanning calorimetry (DSC). The drug content (100±5%), hardness (3.6–4 kg/sq. cm), and friability (0.12-0.15%) has been effective with regard to all the formulated fast dissolving tablets employing starch xanthate. The disintegration time of all the formulated tablets was found to be in the range of 12±0.01 to 312±0.02s. The optimized formulation F5 has the least disintegration time i.e., 12±0.01s. The In vitro wetting time of the formulated tablets was found to be in the range of 76±0.21 to 217±0.17s. The In vitro wetting time was less (i.e., 90s) in optimized formulation F5. The water absorption ratio of the formulated tablets was found to be in the range of 16±0.16 to 174±0.21%. The cumulative drug dissolved in the optimized formulation F5 was found to be 99.83±0.56% in 5 min.Conclusion: The dissolution efficiency of ibuprofen was enhanced when starch xanthate was found to be a superdisintegrant when combined with sodium starch glycolate, croscarmellose sodium and, hence it could be used in the formulation of fast dissolving tablets to provide immediate release of the contained drug within 5 min.
RAPID PCR–BASED DETECTION OPTIMIZATION OF PORCINE DNA IN GELATIN CAPSULE SHELL
Authors: Khayyira Amalia Sitti , Estepane Viktoria Mardhika , Malik Amarila
Published: November 2018

Objective: This study was conducted to optimize the genomic deoxyribonucleic acid (DNA) based molecular detection of gelatin derived from porcine by performing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and duplex PCR method employing cyt B gene.Methods: Optimization was carried out for DNA extraction, PCR conditions, and the sensitivity of the PCR-RFLP method. Due to the very low DNA trace in gelatin after the various manufacturing process, the extraction was optimized to obtain sufficient DNA which was visible on the agarose gel. PCR-RFLP was carried out using universal primers and BsaJI restriction enzyme, and duplex PCR was carried out using two sets of porcine-specific primers. Porcine and bovine DNA were mixed in various concentration to confirm sensitivity of both methods, i.e. 100%, 50%, 10%, 1%, 0.5%, 0.1%, 0.05%, and 0.01%Results: Both methods, PCR-RFLP, and Duplex PCR, were able to detect as low as 0.01% porcine DNA, indicated by the presence of porcine DNA amplicon bands (131 bp and 228 bp for PCR-RFLP, 212 bp and 398 bp for duplex PCR). Although DNA bands presented in low intensity, identification of porcine and bovine species and estimation of DNA quantities were possible.Conclusion: Both conventional PCR methods, i.e. PCR-RFLP and Duplex PCR, were sensitive, specific, and suitable as a rapid initial detection method for molecular detection of porcine in gelatin capsule shells.
OPTIMIZATION OF A NOVEL KINETIC-ASSISTED INFUNDATION FOR RICH-EGCG AND POLYPHENOLS OF WHITE TEA (CAMELLIA SINENSIS) USING CENTRAL COMPOSITE DESIGN
Authors: Shiyan Shaum , Hertiani Triana , Martien Ronny , Nugroho Akhmad Kharis
Published: November 2018

Objective: This research aimed to find modeling and optimization of a novel kinetic-assisted infundation for rich-epigallocatechin gallate (EGCG) and polyphenols extraction from white tea leaf (Camellia sinensis L.).Methods: The optimal conditions for the best extraction of kinetic-assisted infundation were determined using central composite design. The content of EGCG, catechin, gallic acid, caffeine, theobromine, and theophylline was quantified using high-performance liquid chromatography with ultraviolet detection (HPLC/UV-detection). The total polyphenolic content (TPC) and total flavonoid content (TFC) was measured using the spectrophotometric method. The semi-purified extract was characterized by HPLC, fourier transform infrared spectrophotometry-universal attenuated total reflectance (FTIR-UATR), and powder-X ray diffraction (P-XRD). The extraction mechanism of target compounds was analyzed using scanning electron microscopy (SEM) qualitatively.Results: The optimum process for the rich-EGCG and polyphenolic extraction using kinetic-assisted infundation was the concentration of simplicia 14.75 %, the stir rate 440 rpm, and extraction time 12.31 min. The yield of extracts, TPC, TFC, EGCG, caffeine, gallic acid, and theobromine contents in the optimal extraction process were 9.34 %, 70.97 %, 13.95 %, 29.02 %, 11.95 %, 1.33 %, and 0.33 %, respectively.Conclusion: The kinetic-assisted infundation method proved to be easy to apply with good results as an alternative technique for extracting polyphenolic compounds and rich-EGCG from white tea leaves.
Gobierno electrónico, calidad y eficiencia en la relación G2C en el estado de Oaxaca, 2011-2015
Authors: Franco Ríos Jorge Luis , Cruz Meléndez Christian Arturo
Published: November 2018

Con base en la Encuesta Nacional de Calidad e Impacto Gubernamental (ENCIG) del Instituto Nacional de Estadística y Geografía (INEGI), correspondiente a los años 2011, 2013 y 2015, se analiza en qué medida se ha avanzado hacia servicios públicos eficientes y de calidad en el Gobierno del Estado de Oaxaca, específicamente en cuanto a trámites y solicitudes de la ciudadanía, además se estudia como el uso de las Tecnologias de la Información y la Comunicación (TIC) ha impactado en esta relación G2C (Gobierno a Ciudadano) y como podría contribuir a la mejora de la misma. Para lograr esto, se analizan variables como el medio por el cual se realizaron los trámites o pagos (oficina del gobierno, telefonía móvil, kiosko, cajero automático o internet), dificultades a las que se enfrentaron los ciudadanos para realizar dichas transacciones, nivel de satisfacción de los mismos, evaluación de la calidad del servicio por parte de los usuarios y el nivel de soborno o corrupción al que estuvieron expuestos. Para el análisis de la información se recurre al Teorema de Bayes y a la Estadística Descriptiva, con el fin de determinar la relación que existe entre el uso de las TIC en los trámites y servicios de la ciudadanía con las distintas dependencias del Gobierno del Estado y la calidad y eficiencia de los mismos.
Análisis de puestos y sueldos de personal de mando en la Administración Pública Federal 2018
Authors: Sánchez Ildefonso Luis Alfredo
Published: November 2018

Los sueldos en México de los servidores públicos de mando, en la administración pública centralizada, tienen una estructuración compleja, que distingue instituciones y niveles en una misma jerarquía organizacional. Este análisis muestra algunos rasgos de la complejidad y la heterogeneidad salarial en el gobierno federal, relacionadas con el diseño de las estructuras orgánicas de las dependencias.
New Uses of "Old" Media: Exploring Technologies-in-Use in Nunavut
Authors: Coelho Kareena
Published: November 2018

Background This article draws upon findings from interviews and participant-observation in Nunavut, Canada, to analyze internet’s place within the communication landscape.Analysis The author situates the newer medium of broadband internet within the context of television, radio, the postal service, and satellite dishes in Nunavut. She argues that focusing on these persisting platforms provides insight into how internet and its issues are experienced by Nunavummiut users.Conclusions and implications  Contrary to prevalent notions of innovation that privilege newness of form, the usage of persisting media can be dynamic and innovative. The evidence presented builds upon existing research on media usage by Indigenous peoples; it also suggests the potential for Indigenous-media research to reconceptualize innovation, oldness, and newness within the broader field of media and communications. Keywords Indigenous media; Nunavut; Internet; Media archaeology; Polymedia Contexte  Cet article se fonde sur des entretiens et une observation participative effectués au Nunavut (Canada) dans le but d’analyser la place d’internet parmi divers médias disponibles.Analyse  L’auteure situe le média relativement récent d’internet à haut débit au Nunavut par rapport à la télévision, la radio, le service des postes et l’antenne parabolique. Elle soutient qu’un examen de ces derniers médias plus traditionnels peut aider à comprendre comment les utilisateurs du Nunavut gèrent l’internet et les défis qui s’y rapportent.Conclusions et implications  Souvent on a tendance à privilégier les toute dernières technologies, mais les médias traditionnels peuvent encore aujourd’hui s’avérer dynamiques et innovateurs. À cet effet, les données présentées dans cet article viennent compléter des recherches existantes sur l’utilisation des médias par les autochtones. Elles suggèrent qu’il est possible pour la recherche sur les médias autochtones de contribuer à une reconceptualisation de ce qui est ancien, nouveau et innovateur dans le domaine des médias et de la communication.Mots clés  Médias autochtones; Nunavut; Internet; Archéologie médiatique; Polymédias
Evaluación y uso de un péptido sintético para la detección de anticuerpos específicos contra Plasmodium falciparum
Authors: Barrera Sandra M , Adriana Cepeda Adriana Cepeda , Curtidor Hernando , Silva Yolanda
Published: November 2018

Introducción. La malaria continúa siendo una de las enfermedades que causa mayor morbimortalidada nivel mundial. Por esta razón es importante desarrollar herramientas diagnósticas eficaces que se implementen como estrategias para el control de la enfermedad. Objetivos. Estandarizar las condiciones del inmunoensayo enzimático (ELISA), para la detección de IgG específica contra Plasmodium falciparum en sueros de pacientes diagnosticados por gota gruesa con malaria no complicada por P. falciparum, empleando como antígeno un extracto proteico obtenido a partir de cultivo de P. falciparum o un péptido sintético derivado de la proteína de superficie de merozoito GLURP (del inglés: glutamate rich protein). Materiales y métodos. Para la estandarización de la técnica, se utilizaron 22 sueros de pacientes positivos para malaria por P. falciparum y 11 diagnosticados positivos para malaria por P. vivax utilizando la técnica de gota gruesa. Como controles negativos se utilizaron 44 sueros de individuos sanos. Los sueros fueronprobados contra extracto de proteínas del parásito y el péptido sintético IMT 94 derivado de la proteína GLURP, para evaluar las concentraciones y las diluciones óptimas de cada componente del sistema. Para la validación de la técnica se utilizaron 251 sueros de pacientes positivos para P. falciparum y 44 sueros de individuos sanos, diagnosticados utilizando la técnica de gota gruesa. Resultados. La técnica estandarizada con el péptido sintético permitió observar diferencia significativa en el reconocimiento de sueros de pacientes, controles positivos y negativos por los antígenos (extracto de proteínas y péptidos sintéticos). Conclusiones. La metodología usada permite identificar la respuestas inmune específica contra P. falciparum.
Análisis de los programas de evaluación del desempeño de malaria de los laboratorios de salud pública y privados de colombia 2015-2016
Authors: Cortés Cortés Liliana Jazmín , Caicedo Díaz Ricardo Andrés
Published: November 2018

Introducción. Para el fortalecimiento de la calidad del diagnóstico de malaria en Colombia, sedesarrollan los Programas de Evaluación del Desempeño (PED) en los que participan laboratoriosprivados y públicos del país. Objetivo. Analizar los resultados obtenidos en los programas deevaluación del desempeño de malaria de los laboratorios de salud pública y privados de Colombiaen el lapso 2015-2016. Materiales y métodos. Se realizó un estudio de tipo retrospectivo mediantela revisión de los resultados obtenidos por los LSP y laboratorios privados participantes enlos programas de evaluación directa e indirecta del desempeño (PEDD, PEID) de malaria durantelos años 2015 y 2016 en términos de participación, concordancia de positividad y negatividad(Índice Kappa de Cohen), concordancia de especie, de formas parasitarias y de recuento (Z score).Resultados. La participación en el PEID se incrementó de 15% en 2015 a 51% en 2016, asícomo el total de láminas enviadas que en su mayoría cumplían con los criterios establecidos por elLaboratorio Nacional de referencia (LNR). La participación en el PEDD se incrementó de 88%en 2015 a 94% en 2016, con un Índice Kappa de Cohen de 0,97, una media de concordanciade especie parasitaria de 83,3% y de formas parasitarias de 62,5% y una concordancia del recuentoparasitario más frecuente entre -0,9 y 0,9, evidenciándose un mejor desempeño en 2016.Conclusión. Basados en los resultados obtenidos es necesario promover una mayor participaciónde los LSP en los PED de malaria, especialmente en el PEID y aumentar la participación de loslaboratorio privados.
Tratamientos alternativos de medicina tradicional para Chlamydia trachomatis, agente causal de una infección asintomática
Authors: Gutiérrez Daniela , Sánchez Mora Ruth Mélida
Published: November 2018

En la actualidad, Chlamydia trachomatis (CT) es una de las causas más frecuentes de infecciones de transmisión sexual (ITS) y morbilidad reproductiva en el mundo, Incluye tanto países desarrolladoscomo en vía de desarrollo, con un reporte alrededor de 92 millones de casos anuales. CT es una bacteria intracelular obligada cuyo inicio de la infección es asintomático, causa infección crónica, puede generar infección persistente y complicaciones como cáncer de ovario. Las infecciones por CT son asintomáticas en el 70% de las mujeres y el 40% de los hombres, lo que dificulta el diagnóstico en las fases tempranas de la infección y el tratamiento oportuno, lo que conlleva a un aumento en los contagios en la población. De acuerdo con la Organización Mundial de la Salud (OMS), el tratamiento para CT incluye la utilización de antibióticos tipo tetraciclinas, macrólidos y fluoroquinolonas. Sin embargo, a pesar de su alta tasa de eficacia, cada vez son más recurrentes las infecciones. Reportes recientes han demostrado resistencia por parte de los cuerpos elementales y se ha podido determinar que los antibióticos disminuyen la población de lactobacillus vaginales beneficiosos, causando mayores complicaciones en los pacientes. Basados en estos hallazgos, las investigaciones actuales se han centrado en terapias alternativas que reduzcan la actividad antichlamydial y que sean de libre acceso, generando el menor daño posible en los pacientes.
Diagnóstico prenatal de inversión pericentrica del cromosoma cinco de novo en una paciente con gestación a término sin complicaciones posteriores
Authors: Torres Carolina , Usta Carla , Mancilla Laura , Fernández Isabel , Celis Luis Gustavo
Published: November 2018

Los avances en las técnicas de citogenética han permitido detectar con mayor precisión alteracionescromosómicas tanto estructurales como de número. La amniocentesis genética es una prueba invasiva que se realiza entre la semana 16 y 20 de gestación que nos permite detectar distintas alteraciones cromosómicas. Presentamos un caso de una paciente que se le realizó a las 18 semanas de gestación la amniocentesis por edad materna avanzada (39 años), evidenciándose en el cariotipo una inversión pericéntrica del cromosoma 5. Se procedió a realizar cariotipos a los padres, ambos normales. De acuerdo con este resultado a la paciente se le realizó ecosonogramas para detectar si el feto presentaba malformaciones y se realizó asesoramiento genético. A continuación, se hizo evaluación del recién nacido y seguimiento durante 4 años para evaluar fenotipo y desarrollo neurológico. Como se comentará, el cromosoma 5 codifica para muchos genes y es responsable de muchas patologías, de las cuales este paciente no presentó ninguna.
DYNAMICS OF LABOUR PRODUCTIVITY CHANGES IN AGRICULTURE AT THE REGIONAL LEVEL IN SELECTED EUROPEAN UNION COUNTRIES
Authors: Jaroszewska Joanna , Pietrzykowski Robert
Published: November 2018

A comparison of the labour productivity disproportions in agriculture is usually carried out at the state level. Conducted research usually concerns the countries of the so-called old Union and newly admitted countries. As a result of analyses carried out in such a way such and the aggregation effect information about the actual scale of diversification at the regional level are lost. The paper proposes an analysis at the NUTS level 2 for selected European Union countries to show their internal differentiation in terms of labour productivity and changes taking place in the analysed period. It was also found that the distribution of labour productivity in agriculture in the regions should also be defined, which would require the use of more advanced statistical methods.
PATENT ACTIVITY OF THE AGRARIAN SECTOR IN THE CONTEXT OF ITS DEVELOPMENT IN GLOBAL ECONOMY
Authors: Skawińska Eulalia , Zalewski Romuald
Published: November 2018

This paper address the question, whether states’ level of participation and share in patents granted and patent activity development trend in different world’s regions is consistent with the sustainable development paradigm? Presently, this problem is very important and topical, not only due to the states’ and regions’ struggle for their economic position in the world, but also in the social and cultural dimension. The paper analyzes patent activity in the agrarian sector globally, in the context of the level and its trends by state group characterized by different level of development. This two-part analysis was performed at the macro level. The first part highlights the diminishing level of europe and north america in generating patents with a high rate of growth in asia. The second part of the paper documents low patent activity in the agrarian sector. Consequently, an attempt has been made to interpret the causes and effects of this phenomenon in the context of the drive to improve food security in the world, as an important element of sustainable development. To achieve the objective we used scientific literature and data collected by the world intellectual property organization (WIPO) and the world trade organization (WTO). The paper covers the years 2005 to 2016.
CONVERSION OF AGRICULTURAL LAND TO NON-AGRICULTURAL PURPOSES IN SELECTED POLISH METROPOLITAN AREAS
Authors: Sroka Wojciech
Published: November 2018

The aim of the paper is to determine the scale of agricultural land conversion in gmina (municipalities) located in selected metropolitan areas of Poland. Analyses were conducted taking into account the location of agricultural land in relation to the core of metropolitan area and its suitability for agricultural production. The research has shown that in the metropolitan areas selected for analysis, agricultural land conversion in the period 1996–2014 was over twice as fast as the average for Poland, with the most land converted in the core of a metropolitan area, little less in the first zone of gmina around the core, and the least in gmina located on the outskirts of a metropolitan area. The hypothesis saying that the distance of a gmina from the core of the metropolitan area is a significant factor in the differences in conversion processes, and high quality of environmental conditions of agricultural production does not limit (in a significant way) the process of farmland abandonment has been positively verified.
GOOD FOOD PRINT – THE CONCEPT OF AN IT SYSTEM TRACKING THE LEVEL OF GOOD PRACTICES USED IN ORGANIC FOOD PRODUCTION PROCESS AND IN ITS SUPPLY CHAIN
Authors: Woźniakowski Tomasz
Published: November 2018

The aim of the paper is to present and pre-test the method being a modification of the composite measure based on calculating the weighted average value of features corresponding to the degree of various good practices in organic farming. The value calculated by the proposed method is a postulated basis for the operation of an IT system which would enable consumers to follow the production, certification and supply chain processes related to organic food products. The system also allows the manufacturers to choose good sub-suppliers more easily and incline them to achieve perfection at every stage of production. In the paper, the function constituting the main element of the system’s algorithm was tested and modified, and the other postulated functions were described.
THE MOTIVES, PREFERENCES AND TOURIST BEHAVIOR OF POLES PARTICIPATING IN ENOTOURISM TRIPS
Authors: Zawadka Jan
Published: November 2018

The main aim of the study is to show enotourism as a form of spending free time among Poles. The article presents the frequency and directions of enotourism journeys, motives of these travels and ways of spending time during this type of trips. Survey research were conducted among 223 adult Poles. The research was carried out in two stages: in May and October 2017. The questionnaire was submitted to the respondents through social media and thematic forums regarding wine and enotourism. For most respondents, it was relatively unimportant to study the secrets of viticulture or expand knowledge about wine-making and the traditions of the wine region. The possibility of traditional rest, physical activity during a trip or visiting nearby tourist attractions was definitely more important for them. It can be concluded that most Polish enotourists can be qualified as amateurs or dilettante/layman, for whom wine is an attraction that is used by the occasion and sometimes even by chance, and the decision about the place and direction of the trip is often based on a number of other conditions.
Differences in aggressive behavior of male and female students using Rasch stacking
Authors: Alizamar Alizamar , Syahputra Yuda , Afdal Afdal , Ardi Zadrian , Trizeta Leviana
Published: November 2018

Aggressive behavior that occurs among students nowadays indicates a decrease in the quality of education. One of the things that cause this is education which only emphasizes cognitive quality without being balanced with affective. This study aims to describe the differences in aggressive behavior between male and female students in Junior High School of West Sumatera. The sample consisted of 360 students (159 male and 201 female) spread across eight Junior High Schools in West Sumatera. The analysis technique used is the independent sample t-test combined with stacking RASCH model. The analysis show that in general there are differences in aggressive behavior between male and female students. The discussion regarding guidance and counseling services was further explained.
Peran Media Sosial Dalam Upaya Promosi Kesehatan: Tinjauan Literatur
Authors: Leonita Emy , Jalinus Nizwardi
Published: November 2018

Kebutuhan informasi kesehatan yang akurat dan terkini semakin dibutuhkan seiring perkembangan teknologi informasi. Media sosial telah menunjukkan perannya dalam upaya promosi kesehatan di dunia. Untuk itu penelitian ini bertujuan untuk menjawab 1) urgensi pemanfaatan media sosial dalam bidang promosi kesehatan 2) Jenis media sosial yang digunakan dan kelemahannya 3) peran profesional bidang kesehatan melakukan promosi kesehatan berbasis media sosial. Penelurusan jurnal internasional dengan mesin pencarian 1) google scholar 2) since dirrect 3) sage publication 4) elsevier publication. Dari  menelusuri 100 jurnal publikasi internasional, 85 jurnal yang relevan dengan topik yang dikelompokan menjadi 35 jurnal pemanfaatan media sosial, 33 jurnal karakteristik media sosial yang digunakan serta kelemahannya dan 17 jurnal peran profesional kesehatan dalam melakukan promosi kesehatan berbasis media sosial. Hasil Penelusuran mengungkapkan media sosial berkontibusi positif terhadap upaya promosi kesehatan, namun beberapa kelemahan antara lain: kurangnya penjangkauan terhadap audien pasif, informasi palsu dan tidak akurat, kurangnya interaksi dengan audien, keterbatasan kemampuan profesional kesehatan memanfaatkan media sosial sehingga tidak menjamin keberlanjutan program. Profesional bidang kesehatan perlu merancang model promosi kesehatan berbasis media sosial dengan mengintegrasikan media sosial dengan strategi promosi kesehatan serta strategi komunikasi kesehatan.
Inovasi Olahan Durian
Authors: Waryono Waryono
Published: November 2018

Kenagarian Barung Barung Belantai Selatan Kecamatan Koto XI Tarusan merupakan nagari pemekaran tahun 2009 dari kenagarian induk Barung Barung Belantai. Daerah ini memiliki potensi pertanian yang sangat besar seperti tanaman gambir, pala, cengkeh, karet terutama tanaman durian yang melimpah. Melimpahnya potensi ini bisa dilihat disepanjang jalan Padang-Painan, banyak pedagang durian berjejeran, dan ini menjadi daya tarik tersendiri bagi orang yang datang berkunjung ke Pesisir Selatan. Pengunjung pasti singgah untuk sekedar mencicipi rasa buah durian yang terkenal enak dan legit. Setiap panen durian buah melimpah sehingga harga jual durian terkadang menjadi murah. Belum lagi biaya transportasi membawa panen durian dari ladang/perkebunan warga membutuhkan biaya yang besar. Akibatnya warga terkadang membiarkan saja panen durian terbuang sia-sia. Universitas Negeri Padang melaksanakan pelatihan bagi ibu-ibu rumah tangga membuat aneka olahan durian menjadi cake durian dan wingko durian. Wali nagari setempat mengharapkan warga dapat mengolah durian menjadi  makanan khas dan oleh-oleh dari daerah ini sehingga mampu meningkatkan ekonomi keluarga serta mendukung pengembangan pariwisata Pesisir Selatan.
Diversion and Restorative Justice in the Criminal Justice System of Children in Indonesia
Authors: Darmika Ika
Published: November 2018

Diversity and Justice Justice is the norm in the Criminal Justice System in Indonesia, as regulated in Law Number 2012 on the System Juvenile Justice. The latest Law Number 11 Year 2012 was not available to be separated by UN Resolution Number 44.25 about Convention of the Rights which was ratified by the Indonesian Government dated January 26, January 1990 in the Presidential Decree No. 36 Year 1990. Convention on the Rights of the Children of the Republic of Indonesia was the basis of the consideration of the establishment of Law Number 11 of 2012 about Juvenile Criminal Justice System which replaced Law Number 3 1997 concerning Juvenile Court. At this time, there are a number of developed countries that have implemented diversion, among others is Australia. Australia has Act on Juvenile Crimes (The Young Offenders Act 1977).In which the Law gives the authority of lawyers (police)to do diversion child offender. This thing can be known from the purpose of the Juvenile Criminal Act Law. In Australia, the policymaking has the authority to do diversion in handling crime done by child. Authority is done with consideration: a) avoiding labeling or stigma which was caused by the effects of the system judicial justice. b) There are doubts about whether to progress from treatment to children. In Indonesia, regulated in Law Number 11 of 2012 about the Juvenile Criminal Justice System, which began after 2 years promulgated on July 30, 2012. In Law Number 11 of 2012, diversion was regulated in Article 17, Article 6 / Article 15. Regarding the restorative justice in developed countries, restorative justice not only in academic fields and practical practice and criminology North America, Australia, and some Europeans, restorative justice has been applied to all know the conventional criminal justice process, namely the investigation, prosecution, stage adjudication, and the stages of the trial. The justice-restructuring process looks for a facility dialogue between various parties affected by crime, including victims, perpetrators supporters and community are all over. Death involves the process that all parties who acted in crime were at the same time together to try to complete the scrutiny of how the negotiation after the crime has taken place Indonesia trial justice regulated in Article 1 Article 6, Article 5 (1) and Article 8 Section (1)Law Number 11 Year 2012.
TECHNOLOGY OF SHAFT MECHANICAL GEAR REPAIR USING CONSUMABLES GROUP LOCTITE
Authors: Kokorinov Ilya Igorevich , Panasenko Nickolay Nickitovich
Published: November 2018

The article presents technological measures proposed to provide a modern level of maintainability of mechanical transmission shafts for motor transport, characterized by their ability to maintain a workable and control-fit condition, as well as blocking effect and easy disassembling. As the supply material for restoration of shafts, the German-American brand LOCTITE is used, which is fit for adhesives, sealants and surface treatments. Technological methods for repairing shafts provide for the selection of the most rational technique of repair and protection against wear of shaft-bush joints, depending on the wear degree of the shaft parts, as well as the choice of repair materials in the LOCTITE® repair system. It has been found that the technology of repairing the shaft-bush joints with application of LOCTITE materials contributes to prevention of common failures and prolongation of shaft service life. After the repair of shafts there is excluded the wastes and additional costs for replacing parts of shaft-bushing connections; facilitated disassembly of the unit and shaft mechanisms; ensured trouble-free and smooth operation of the unit by bringing the parameters of the worn-out shaft part to the parameters of the new one.
IMPROVEMENT OF TECHNOLOGICAL PROCESS IN CATALYTIC REFORMING UNIT FOR OPTIMIZING TECHNOLOGICAL PARAMETERS
Authors: Subbotkin Anton Sergeevich , Artemieva Natalia Nickolaevna
Published: November 2018

Increasing the efficiency of the plant for producing aromatic hydrocarbons by catalytic reforming requires the rational use of resources and equipment. Increasing the efficiency of the devices contributes to optimization of the plant as a whole. It is proposed to modernize the construction of the trays of distillation columns and replace the sorbent of the adsorption columns. The diameter of contact of a bubble tray has been calculated. It was supposed to increase efficiency of drying circulation gases both during start and operation of reforming catalyst and during catalyst regeneration. There are enumerated the parameters of the proposed drying method, such as using aluminum oxide, aluminum silicate, or carbonic substance as porous matrix, as well as sorbent regeneration in a gas flow at a certain temperature.