bluuebunny/crossref_metadata_2025 huggingface dataset:
Cerebral Small Vessel Disease and Depression Among Intracerebral Hemorrhage Survivors
Authors: Castello Juan Pablo , Pasi Marco , Kubiszewski Patryk , Abramson Jessica R. , Charidimou Andreas , Kourkoulis Christina , DiPucchio Zora , Schwab Kristin , Anderson Christopher D. , Gurol M. Edip , Greenberg Steven M. , Rosand Jonathan , Viswanathan Anand , Biffi Alessandro
Published: September 2021

Background and Purpose:

Intracerebral hemorrhage (ICH) is an acute manifestation of cerebral small vessel disease (CSVD), usually cerebral amyloid angiopathy or hypertensive arteriopathy. CSVD-related imaging findings are associated with increased depression incidence in the general population. Neuroimaging may, therefore, provide insight on depression risk among ICH survivors. We sought to determine whether CSVD CT and magnetic resonance imaging markers are associated with depression risk (before and after ICH), depression remission, and effectiveness of antidepressant treatment.

Methods:

We analyzed data from the single-center longitudinal ICH study conducted at Massachusetts General Hospital. Participants underwent CT and magnetic resonance imaging imaging and were followed longitudinally. We extracted information for neuroimaging markers of CSVD subtype and severity. Outcomes of interest included pre-ICH depression, new-onset depression after ICH, resolution of depressive symptoms, and response to antidepressant treatment.

Results:

We followed 612 ICH survivors for a median of 47.2 months. Multiple CSVD-related markers were associated with depression risk. Survivors of cerebral amyloid angiopathy-related lobar ICH were more likely to be diagnosed with depression before ICH (odds ratio, 1.68 [95% CI, 1.14–2.48]) and after ICH (sub-hazard ratio, 1.52 [95% CI, 1.12–2.07]), less likely to achieve remission of depressive symptoms (sub-hazard ratio, 0.69 [95% CI, 0.51–0.94]), and to benefit from antidepressant therapy (
P
=0.041). Cerebral amyloid angiopathy disease burden on magnetic resonance imaging was associated with depression incidence and treatment resistance (interaction
P
=0.037), whereas hypertensive arteriopathy disease burden was only associated with depression incidence after ICH.

Conclusions:

CSVD severity is associated with depression diagnosis, both before and after ICH. Cerebral amyloid angiopathy-related ICH survivors are more likely to experience depression (both before and after ICH) than patients diagnosed with hypertensive arteriopathy-related ICH, and more likely to report persistent depressive symptoms and display resistance to antidepressant treatment.
Let's Tweet Again? Social Networks and Literature Achievement in High School Students
Authors: Barbetta Gian Paolo , Canino Paolo , Cima Stefano
Published: September 2021

The availability of cheap Wi-Fi Internet connections has encouraged schools to adopt Web 2.0 platforms for teaching, with the intention of stimulating students’ academic achievement and participation in school. Moreover, during the recent explosion of the COVID-19 crisis that forced many countries to close schools (as well as offices and factories), the widespread diffusion of these applications kept school systems going. Despite their widespread use as teaching tools, the effect of adopting Web 2.0 platforms on student performance has never been rigorously tested. We fill this gap in the literature by analyzing the impact of using Twitter as a teaching tool on high school students’ literature skills. Based on a large-scale, randomized controlled trial that involved seventy schools and about 1,500 students, we find that using Twitter to teach literature has an overall negative effect on students’ average achievement, reducing standardized test scores by about 25 percent of a standard deviation. The negative effect is stronger on students who usually perform better.
Adesmia subtropicalis (Leguminosae, Papilionoideae, Dalbergieae), a new endangered species from the Brazilian Pampas
Authors: MONTEIRO THIAGO COBRA E , IGANCI JOÃO RICARDO VIEIRA , MIOTTO SILVIA T.S. , FORTUNA-PEREZ ANA PAULA
Published: September 2021

In the context of an ongoing taxonomic review of Adesmia subg. Adesmia ser. Bicolores, a new endangered species endemic to Rio Grande do Sul state, Brazil, is herein described. The new species present a long glandular ochraceous indumentum, flowers 10–15 mm long, and arilated seeds. Information about morphology, differences from closely related species, phenology, conservation status, and etymology are provided.
Aloe uigensis (Asphodelaceae subfam. Alooideae), a new species from northwestern Angola
Authors: SMITH GIDEON F. , LAUTENSCHLÄGER THEA
Published: September 2021

A new species of Aloe, A. uigensis (Asphodelaceae subfam. Alooideae), is described from northwestern Angola. It is a non-proliferous, single-stemmed species that bears narrowly elongated, acuminate racemes with orange to pale reddish flowers. Aloe uigensis is compared to some long-known as well as recently described species of Aloe from Angola, but does not have close relatives with which it can be confused in the country.
A new species of Oligosoma (Squamata: Scincidae) from the northern North Island, New Zealand
Authors: BARR BENJAMIN P. , CHAPPLE DAVID G. , HITCHMOUGH RODNEY A. , PATTERSON GEOFF B. , BOARD NGĀTIWAI TRUST
Published: September 2021

New Zealand is home to a diverse cool temperate assemblage of skinks, with 60+ identified taxa (genus Oligosoma Girard), of which only 50 have been formally described. Here we describe a new species (Oligosoma kakerakau sp. nov.) from Bream Head Scenic Reserve, near Whangārei Heads, Northland. This species is considered to be conspecific with a single specimen (Oligosoma “Whirinaki”) previously reported (in 2003) from Whirinaki Te Pua-a-Tāne Conservation Park ~370 km further south. Oligosoma kakerakau sp. nov. can be distinguished from all other members of the genus by a combination of a distinctive “teardrop” marking below the eye, a distinctive mid-lateral stripe, and the colouration and pattern on its ventral surface. Our phylogenetic analyses indicate that Oligosoma kakerakau sp. nov. is most closely related to O. zelandicum (Gray), and more distantly to O. striatum (Buller) and O. homalonotum (Boulenger). Sea level changes during the Pliocene, such as the formation of the Manawatū Strait, may have contributed to the divergence between Oligosoma kakerakau sp. nov. and O. zelandicum. We discuss the distribution, ecology and conservation of Oligosoma kakerakau sp. nov., and outline future research and conservation priorities for the species.
The genus Stilbocoris in the Malagasy area (Hemiptera: Heteroptera: Rhyparochromidae)
Authors: KONDOROSY ELŐD , ZÁMBÓ ANDRÁS
Published: September 2021

The species of Stilbocoris Bergroth, 1893 (Hemiptera: Heteroptera: Rhyparochromidae: Rhyparochrominae: Drymini) occurring in Madagascar and surrounding islands are reviewed. Four described and two undescribed species (S. scudderi sp. nov. and S. slateri sp. nov.) are recognized, the latter two apparently being endemic to Madagascar. The following new country records are provided: S. distinctus Scudder, 1962: Ivory Coast, Ghana, Togo, Central African Republic, Gabon, Cameroon and Madagascar; S. galla Linnavuori, 1978: Kenya, Tanzania and Madagascar; S. triangularis Linnavuori, 1978: Senegal, Tanzania and Madagascar. A key for the species occurring in the Malagasy area is presented.
Vasopora ceramica n. gen., n. sp.—a new abyssal cyclostome bryozoan from polymetallic nodules in the Russian exploration area, Clarion–Clipperton Fracture Zone, eastern Pacific Ocean
Authors: GRISCHENKO ANDREI V. , GORDON DENNIS P. , MELNIK VIACHESLAV P.
Published: September 2021

A new abyssal cyclostome bryozoan genus and species, Vasopora ceramica n. gen., n. sp., is described from the eastern Russian exploration area of the Clarion–Clipperton Fracture Zone based on newly collected material from Yuzhmorgeologiya GLD4–19 station 421 (13.23408° N, 134.22180° W, 4809 m depth). Generic characters include an erect pedunculate colony with a distinct boundary between column and flared capitulum, short autozooidal peristomes in a single whorl, numerous alveoli, a central unidirectional sac-like gonozooid covered by a surficial network of crossed ridges continuous with adjacent rims of alveoli, a laterally opening ooeciopore, and the entire capitulum surface being minutely densely granular to subspinulate. Whereas the skeletal microstructure of the capitulum surface comprises irregular imbricated crystallites, the column has a planar-spherulitic fabric of acicular crystallites in fan-like arrays, and there are no pseudopores. The sharp boundary between capitulum and column, with their different microstructure separates Vasopora n. gen. from the two existing genera of Alyonushkidae that are found in the same environment. Vasopora n. gen. has a stalk formed of calcified exterior wall, whereas it is interior-walled in Alyonushka and Calyssopora.
Top-of-Atmosphere Albedo Bias from Neglecting Three-Dimensional Cloud Radiative Effects
Authors: Singer Clare E. , Lopez-Gomez Ignacio , Zhang Xiyue , Schneider Tapio
Published: September 2021

Clouds cover on average nearly 70% of Earth’s surface and regulate the global albedo. The magnitude of the shortwave reflection by clouds depends on their location, optical properties, and three-dimensional (3D) structure. Due to computational limitations, Earth system models are unable to perform 3D radiative transfer calculations. Instead they make assumptions, including the independent column approximation (ICA), that neglect effects of 3D cloud morphology on albedo. We show how the resulting radiative flux bias (ICA-3D) depends on cloud morphology and solar zenith angle. We use high-resolution (20–100-m horizontal resolution) large-eddy simulations to produce realistic 3D cloud fields covering three dominant regimes of low-latitude clouds: shallow cumulus, marine stratocumulus, and deep convective cumulonimbus. A Monte Carlo code is used to run 3D and ICA broadband radiative transfer calculations; we calculate the top-of-atmosphere (TOA) reflected flux and surface irradiance biases as functions of solar zenith angle for these three cloud regimes. Finally, we use satellite observations of cloud water path (CWP) climatology, and the robust correlation between CWP and TOA flux bias in our LES sample, to roughly estimate the impact of neglecting 3D cloud radiative effects on a global scale. We find that the flux bias is largest at small zenith angles and for deeper clouds, while the albedo bias is most prominent for large zenith angles. In the tropics, the annual-mean shortwave radiative flux bias is estimated to be 3.1 ± 1.6 W m−2, reaching as much as 6.5 W m−2 locally.
Vertical Divergence of the Atmospheric Momentum Flux near the Sea Surface at a Coastal Site
Authors: Mahrt L. , Nilsson Erik , Rutgersson Anna , Pettersson Heidi
Published: September 2021

Motivated by previous studies, we examine the underestimation of the sea surface stress due to the stress divergence between the surface and the atmospheric observational level. We analyze flux measurements collected over a 6-yr period at a coastal tower in the Baltic Sea encompassing a wide range of fetch values. Results are posed in terms of the vertical divergence of the stress scaled by the stress at the lowest observational level. The magnitude of this relative stress divergence increases with increasing stability and decreases with increasing instability, possibly partly due to the impact of stability on the boundary layer depth. The magnitude of the relative stress divergence increases modestly with decreasing wave age. The divergence of the heat flux is not well correlated with the divergence of the momentum flux evidently due to the greater influence of advection on the temperature. Needed improvement of the conceptual framework and needed additional measurements are noted.
Extensive Pneumocephalus Secondary to Petrous Bone Cholesteatoma
Authors: Alanazy Sultan , Cho Sung Il
Published: September 2021

Pneumocephalus refers to air inside the cranium; however, otogenic pneumocephalus is rarely reported in the literature. The neurological presentations of pneumocephalus include headache, lethargy, confusion, disorientation, and seizure. Here, we have reported a case of a 42-year-old woman with extensive pneumocephalus and cerebrospinal fluid leak secondary to petrous bone cholesteatoma. She presented to the emergency department with sudden headache and left ear discharge. Physical examination revealed watery otorrhea through a hole in the tympanic membrane. Radiological studies demonstrated extensive soft tissue in the left middle ear and mastoid extending to the internal auditory canal. Free intracranial air was observed, and bony destruction was seen in the cochlea, vestibule, and semicircular canals. The patient was managed surgically via the transotic approach and fully recovered. Although otogenic pneumocephalus is rarely encountered in clinical practice, early diagnosis and urgent management are important to prevent fatal complications.
The Impact of Ownership Structure on Earnings Management: The Case of Vietnam
Authors: Tran Manh Dung , Dang Ngoc Hung
Published: September 2021

This study is conducted to investigate the impact of ownership structure on earnings management in emerging countries and Vietnam as the case study. In this research, we explore how three components of ownership structure, including ownership concentration of managers, foreign ownership ratio, and state ownership ratio, influence earnings management. In addition, we also consider whether ownership structure influences profit management during financial constraints. REM, FEM, GLS, and GMM regression methods are employed for processing data. The results show that ownership structure with foreign ownership has a positive effect on earnings management, whereas one with a proportion of state ownership has a contradicting effect. While the degree of ownership concentration does not affect the profit management, in the context of financial restrictions, the ownership ratio has an impact on the management of earnings. Control variables in the model such as firm size, financial leverage, growth rate, profitability, and audit quality, all have an impact on earnings management. The results could, potentially, be the basis to help firms in restricting earnings management behavior.
Pediatric Tracheostomy Outcomes After Development of a Multidisciplinary Airway Team: A Quality Improvement Initiative
Authors: Chorney Stephen R. , Brown Ashley F. , Brooks Rebecca L. , Bailey Candace , Whitney Cindy , Sewell Ashley , Johnson Romaine F.
Published: September 2021

Objectives

To analyze a multidisciplinary tracheostomy team’s effect on length of stay and cost.

Methods

An airway management program using a balanced scorecard was created to track key performance measures. Interventions included weekly rounding, standardized placement, postoperative care, and caregiver education. Process measures included time to first education, speech‐language pathology consultation rates, and pretracheostomy consultations. Outcome measures focused on the total length of stay, 30‐day revisit rates after discharge, accidental decannulation rate, and standardized cost. Regression analysis was used to predict the program’s effect on length of stay and total cost.

Results

In total, 239 children met inclusion. The mean time to first education class was reduced from 13.7 to 1.9 days (P <. 001). The speech‐language pathology consultation rate increased from 68% to 95% (P <. 001), and the presurgical consultation rate with the tracheostomy team increased from 14% to 93% (P <. 001). The length of stay decreased from 133 to 96 days (P =. 006). Total costs were lower for short admissions but higher for prolonged admissions. Revisits within 30 days remained stable over time (18%).

Discussion

Establishing a multidisciplinary tracheostomy team results in improvements in quality metrics when caring for children with tracheostomies. Controlling for associated factors showed the mean length of stay decreased significantly in the first full year of program implementation. Cost analysis estimated significant reductions for tracheostomy patients spending less time in the hospital.

Implications for Practice

A airway management program can positively affect tracheostomy processes and outcomes.
Weakly-Supervised Single-view Dense 3D Point Cloud Reconstruction via Differentiable Renderer
Authors: Jin Peng , Liu Shaoli , Liu Jianhua , Huang Hao , Yang Linlin , Weinmann Michael , Klein Reinhard
Published: September 2021

In recent years, addressing ill-posed problems by leveraging prior knowledge contained in databases on learning techniques has gained much attention. In this paper, we focus on complete three-dimensional (3D) point cloud reconstruction based on a single red-green-blue (RGB) image, a task that cannot be approached using classical reconstruction techniques. For this purpose, we used an encoder-decoder framework to encode the RGB information in latent space, and to predict the 3D structure of the considered object from different viewpoints. The individual predictions are combined to yield a common representation that is used in a module combining camera pose estimation and rendering, thereby achieving differentiability with respect to imaging process and the camera pose, and optimization of the two-dimensional prediction error of novel viewpoints. Thus, our method allows end-to-end training and does not require supervision based on additional ground-truth (GT) mask annotations or ground-truth camera pose annotations. Our evaluation of synthetic and real-world data demonstrates the robustness of our approach to appearance changes and self-occlusions, through outperformance of current state-of-the-art methods in terms of accuracy, density, and model completeness.
Pooling Nasopharyngeal Swab Specimens to Improve Testing Capacity for SARS-CoV-2 by Real-Time RT-PCR
Authors: Handous Imene , Hannachi Naila , Marzouk Manel , Hazgui Olfa , Bouafif Ep Ben Alaya Nissaf , Boukadida Jalel
Published: September 2021

Background

The detection of SARS-CoV-2 using qRT-PCR with the pooling of samples can reduce workload and costs especially when the prevalence rate of COVID-19 in a population is low.

To analyse the effect of pooling samples on the sensitivity of RT-qPCR for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection, we compared the cycle threshold (Ct) values of pools of 5 and 10 that tested positive with Ct values of individual samples that tested positive in that pool. Twenty positive nasopharyngeal (NP) specimens with low to high viral load were selected and pooled individually with four and nine negative NP.

Results

In NP specimens, the sensitivity of pools of 5 and 10 were 90 and 85%, compared to individual sample testing, respectively. The RT-qPCR sensitivity of pools of 5 and 10 against individual testing were not significantly different (p > 0.05). Detection of positive samples with low Ct values (< 36) was consistently achieved in pools of 5 and 10. However, there were higher false negatives when samples with high ct values (> 36) were pooled and tested. The mean Ct values obtained with the 5-sample pooled testing exceeded individual sample testing by 1.85 ± 1.09 cycles, while Ct values obtained with the 10-sample pooling exceeded individual sample testing by 3.4 ± 1.65 cycles.

Conclusions

In a low prevalence setting, testing capacity can be increased by pooling 5 or 10 samples, but the risk of additional false negatives needs to be considered
Using BioPAX-Parser (BiP) to enrich lists of genes or proteins with pathway data
Authors: Agapito Giuseppe , Cannataro Mario
Published: September 2021

Background

Pathway enrichment analysis (PEA) is a well-established methodology for interpreting a list of genes and proteins of interest related to a condition under investigation. This paper aims to extend our previous work in which we introduced a preliminary comparative analysis of pathway enrichment analysis tools. We extended the earlier work by providing more case studies, comparing BiP enrichment performance with other well-known PEA software tools.

Methods

PEA uses pathway information to discover connections between a list of genes and proteins as well as biological mechanisms, helping researchers to overcome the problem of explaining biological entity lists of interest disconnected from the biological context.

Results

We compared the results of BiP with some existing pathway enrichment analysis tools comprising Centrality-based Pathway Enrichment, pathDIP, and Signaling Pathway Impact Analysis, considering three cancer types (colorectal, endometrial, and thyroid), for a total of six datasets (that is, two datasets per cancer type) obtained from the The Cancer Genome Atlas and Gene Expression Omnibus databases. We measured the similarities between the overlap of the enrichment results obtained using each couple of cancer datasets related to the same cancer.

Conclusion

As a result, BiP identified some well-known pathways related to the investigated cancer type, validated by the available literature. We also used the Jaccard and meet-min indices to evaluate the stability and the similarity between the enrichment results obtained from each couple of cancer datasets. The obtained results show that BiP provides more stable enrichment results than other tools.
Association between anxiety symptoms and atrial fibrillation in a community cohort of Chinese older adults: a case-control study
Authors: Shen Zhu-Xia , Sun Yu-Min , Gu Hui-Hui , Zhang Yan , Shen Zhi-Wen , Liang Xiao-Niu , Ding Ding , Wang Jun
Published: September 2021

Background

The association between anxiety and atrial fibrillation (AF) remains unclear. Moreover, this association has rarely been studied in Chinese individuals aged 60 years or older. This study investigated the association between anxiety and AF in a community-based case-control study of older adult residents in urban China.

Methods

The cases and controls were from a community-based study conducted in the Jingansi community in Shanghai, China, between January 2010 and December 2012. A total of 3622 residents aged 60 years or older without severe vision, hearing, or speaking impairments were eligible to participate in the physical examinations and questionnaire survey. AF was assessed based on a previous physician’s diagnosis, electrocardiogram, ambulatory electrocardiogram, or echocardiogram. Anxiety was evaluated using the Zung Self-Rating Anxiety Scale (ZSAS). Using the AF group as a reference, the control group consisted of randomly selected age- and sex-matched individuals in a 1:5 ratio (case:control = 1:5). The association between anxiety and AF in the AF group and the multifactor-matched control group was explored using logistic regression.

Results

In the AF and control groups, after adjusting for a history of coronary heart disease, valvular heart disease, hypertension, stroke, hyperlipidemia, and diabetes, as well as depression score, ZSAS scores (odds ratio 1.07; 95% confidence interval 1.02–1.12; p = 0.003), and anxiety symptoms (odds ratio 3.94; 95% confidence interval 1.06–14.70; p = 0.041) were associated with AF.

Conclusions

Anxiety symptoms were associated with AF in a Chinese older population. This suggests that older adults who have anxiety symptoms may need psychological intervention or treatment in daily life and care.
Sequential Multiple Assignment Randomized Trial (SMART) to identify optimal sequences of telemedicine interventions for improving initiation of insulin therapy: A simulation study
Authors: Yan Xiaoxi , Matchar David B. , Sivapragasam Nirmali , Ansah John P. , Goel Aastha , Chakraborty Bibhas
Published: September 2021

Background

To examine the value of a Sequential Multiple Assignment Randomized Trial (SMART) design compared to a conventional randomized control trial (RCT) for telemedicine strategies to support titration of insulin therapy for Type 2 Diabetes Mellitus (T2DM) patients new to insulin.

Methods

Microsimulation models were created in R using a synthetic sample based on primary data from 63 subjects enrolled in a pilot study of a smartphone application (App), Diabetes Pal compared to a nurse-based telemedicine strategy (Nurse). For comparability, the SMART and an RCT design were constructed to allow comparison of four (embedded) adaptive interventions (AIs).

Results

In the base case scenario, the SMART has similar overall mean expected HbA1c and cost per subject compared with RCT, for sample size of n = 100 over 10,000 simulations. SMART has lower (better) standard deviations of the mean expected HbA1c per AI, and higher efficiency of choosing the correct AI across various sample sizes. The differences between SMART and RCT become apparent as sample size decreases. For both trial designs, the threshold value at which a subject was deemed to have been responsive at an intermediate point in the trial had an optimal choice (i.e., the sensitivity curve had a U-shape). SMART design dominates the RCT, in the overall mean HbA1c (lower value) when the threshold value is close to optimal.

Conclusions

SMART is suited to evaluating the efficacy of different sequences of treatment options, in addition to the advantage of providing information on optimal treatment sequences.
Novel tools and strategies for breaking schistosomiasis transmission: study protocol for an intervention study
Authors: Trippler Lydia , Hattendorf Jan , Ali Said Mohammed , Ame Shaali Makame , Juma Saleh , Kabole Fatma , Knopp Stefanie
Published: September 2021

Background

Global elimination of schistosomiasis as a public health problem is set as target in the new World Health Organization’s Neglected Tropical Diseases Roadmap for 2030. Due to a long history of interventions, the Zanzibar islands of Tanzania have reached this goal since 2017. However, challenges occur on the last mile towards interruption of transmission. Our study will investigate new tools and strategies for breaking schistosomiasis transmission.

Methods

The study is designed as an intervention study, documented through repeated cross-sectional surveys (2020–2024). The primary endpoint will be the sensitivity of a surveillance-response approach to detect and react to outbreaks of urogenital schistosomiasis over three years of implementation. The surveys and multi-disciplinary interventions will be implemented in 20 communities in the north of Pemba island. In low-prevalence areas, surveillance-response will consist of active, passive and reactive case detection, treatment of positive individuals, and focal snail control. In hotspot areas, mass drug administration, snail control and behaviour change interventions will be implemented. Parasitological cross-sectional surveys in 20 communities and their main primary schools will serve to adapt the intervention approach annually and to monitor the performance of the surveillance-response approach and impact of interventions. Schistosoma haematobium infections will be diagnosed using reagent strips and urine filtration microscopy, and by exploring novel point-of-care diagnostic tests.

Discussion

Our study will shed light on the field applicability and performance of novel adaptive intervention strategies, and standard and new diagnostic tools for schistosomiasis elimination. The evidence and experiences generated by micro-mapping of S. haematobium infections at community level, micro-targeting of new adaptive intervention approaches, and application of novel diagnostic tools can guide future strategic plans for schistosomiasis elimination in Zanzibar and inform other countries aiming for interruption of transmission.

Trial registration ISRCTN, ISCRCTN91431493. Registered 11 February 2020, https://www.isrctn.com/ISRCTN91431493
Insaka: mobile phone support groups for adolescent pregnant women living with HIV
Authors: Simpson Nikita , Kydd Anna , Phiri Mwelwa , Mbewe Madalitso , Sigande Lucheka , Gachie Thomas , Ngobeni Malebo , Monese Tebogo , Figerova Zuzana , Schlesinger Hugo , Bond Virginia , Belemu Steve , Simwinga Musonda , Schaap Ab , Biriotti Maurice , Fidler Sarah , Ayles Helen
Published: September 2021

Background

Mobile phone-based interventions have been demonstrated in different settings to overcome barriers to accessing critical psychosocial support. In this study, we aimed to assess the acceptability and feasibility of a phone-based, peer-to-peer support group intervention for adolescent pregnant women aged 15–24 years living with HIV in Zambia.

Methods

Sixty-one consenting participants were recruited from Antenatal Clinics of two large urban communities in Lusaka. They were invited to participate in the mobile phone-based intervention that allowed them to anonymously communicate in a small group led by a facilitator for 4 months. A mixed methods approach was used to assess acceptability and feasibility, including a focus group discussion, pre- and post-intervention interview and analysis of the content of the text message data generated.

Results

Participants reported finding the platform “not hard to use” and enjoyed the anonymity of the groups. Seventy-one percent of participants (n = 43) participated in the groups, meaning they sent text messages to their groups. Approximately 12,000 text messages were sent by participants (an average of 169 messages/user and 6 mentors in 6 groups. Topics discussed were related to social support and relationships, stigma, HIV knowledge and medication adherence.

Conclusion

The study showed that the intervention was acceptable and feasible, and highlighted the potential of the model for overcoming existing barriers to provision of psychosocial support to this population.
Perceptions and knowledge of air pollution and its health effects among caregivers of childhood cancer survivors: a qualitative study
Authors: Waters Austin R. , Warner Echo L. , Vaca Lopez Perla L. , Kirchhoff Anne C. , Ou Judy Y.
Published: September 2021

Background

Emerging research suggests that survivors of childhood and adolescent cancers are at risk for morbidity and mortality associated with air pollutants. However, caregiver perceptions of the effects of air pollution are unknown. Thus, to address this gap we described caregivers’ perceptions of air pollution’s impact on general population health and specifically on childhood cancer survivors, and caregivers’ air pollution information-seeking and exposure reduction behaviors.

Methods

Participants were Utah residents, ≥18 years, and caregiver of a childhood cancer survivor who had completed treatment. Semi-structured interviews were conducted with caregivers to describe their perspectives on air quality, how air pollution impacts health (general population and survivor health), and their information seeking and exposure reduction behaviors. Interviews were recorded, transcribed, and analyzed through two rounds of structured coding.

Results

Caregivers (N = 13) were non-Hispanic white and primarily females (92.3%) between 30 and 49 years old (46.2%). Most families lived within the Wasatch Front (69.2%), the main metropolitan of Utah. Two categories emerged pertaining to caregiver’s perceptions of air pollution: 1) Limited awareness about the health effects of air pollution, and 2) Unsuccessful information seeking and minimal exposure reduction behaviors. All caregivers held negative perceptions of air pollution in Utah, but most were unaware of how pollution affects health. While some families limited air pollution exposure by avoiding outdoor activity or physically leaving the region, few practiced survivor-specific exposure reduction. Nearly half of caregivers worried about potential effects of air pollution on survivor health and wanted more information.

Conclusions

Despite negative perceptions of air pollution, caregivers were divided on whether air pollution could impact survivor health. Few caregivers engaged in exposure reduction for their cancer survivor. As air pollution levels increase in the U.S., continued research on this topic is essential to managing cancer survivor respiratory and cardiovascular health.
The value of complete blood count for the prognosis analysis of preoperative esophageal squamous cell carcinoma
Authors: Lv Xiang , Han Songtao , Xu Bin , Deng Yuqin , Feng Yangchun
Published: September 2021

Objective

To investigate the predictive value of preoperative complete blood count for the survival of patients with esophageal squamous cell carcinoma.

Methods

A total of 1587 patients with pathologically confirmed esophageal squamous cell carcinoma who underwent esophagectomy in the Cancer Hospital Affiliated to Xinjiang Medical University from January 2010 to December 2019 were collected by retrospective study. A total of 359 patients were as the validation cohort from January 2015 to December 2016, and the remaining 1228 patients were as the training cohort. The relevant clinical data were collected by the medical record system, and the patients were followed up by the hospital medical record follow-up system. The follow-up outcome was patient death. The survival time of all patients was obtained. The Cox proportional hazards regression model and nomogram were established to predict the survival prognosis of esophageal squamous cell carcinoma by the index, their cut-off values obtained the training cohort by the ROC curve. The Kaplan-Meier survival curve was established to express the overall survival rate. The 3-year and 5-year calibration curves and C-index were used to determine the accuracy and discrimination of the prognostic model. The decision curve analysis was used to predict the potential of clinical application. Finally, the validation cohort was used to verify the results of the training cohort.

Results

The cut-off values of NLR, NMR, LMR, RDW and PDW in complete blood count of the training cohort were 3.29, 12.77, 2.95, 15.05 and 13.65%, respectively. All indicators were divided into high and low groups according to cut-off values. Univariate Cox regression analysis model showed that age (≥ 60), NLR (≥3.29), LMR (< 2.95), RDW (≥15.05%) and PDW (≥13.65%) were risk factors for the prognosis of esophageal squamous cell carcinoma; multivariate Cox regression analysis model showed that age (≥ 60), NLR (≥3.29) and LMR (< 2.95) were independent risk factors for esophageal squamous cell carcinoma. Kaplan-Meier curve indicated that age <  60, NLR < 3.52 and LMR ≥ 2.95 groups had higher overall survival (p <  0.05). The 3-year calibration curve indicated that its predictive probability overestimate the actual probability. 5-year calibration curve indicated that its predictive probability was consistent with the actual probability. 5 c-index was 0.730 and 0.737, respectively, indicating that the prognostic model had high accuracy and discrimination. The decision curve analysis indicated good potential for clinical application. The validation cohort also proved the validity of the prognostic model.

Conclusion

NLR and LMR results in complete blood count results can be used to predict the survival prognosis of patients with preoperative esophageal squamous cell carcinoma.
A survey of mental health literacy in Japanese high school teachers
Authors: Yamaguchi Satoshi , Foo Jerome Clifford , Kitagawa Yuko , Togo Fumiharu , Sasaki Tsukasa
Published: September 2021

Background

School teachers are well-positioned to recognize mental health problems in their students and to help them seek appropriate help. Therefore, teachers need to have high levels of mental health literacy (MHL). In East Asia, however, few studies have examined MHL levels in teachers. In this study, MHL levels were investigated in Japanese teachers.

Methods

Teachers (n = 665) from 27 Japanese high schools answered a self-administered questionnaire which assessed (a) knowledge about mental health/illnesses, (b) correct recognition of specific illnesses (depression, schizophrenia and panic disorder), (c) confidence in helping students with depressive symptoms, and (d) confidence in teaching mental health knowledge to students.

Results

The average proportion of correct answers to the knowledge questions (n = 20) was 58.1%. The proportion of those who correctly answered about the presence of a sharp increase of mental illnesses in adolescence was 51.7%. Few teachers correctly answered about the life-time prevalences of major mental illness in general (21.9%), depression (37.8%) and schizophrenia (19.8%). Depression, schizophrenia and panic disorder in vignette were correctly recognized by 54.1, 35.3 and 78.0% of teachers, respectively. Correct recognition was significantly lower in male than in female teachers. Only a small proportion of teachers had confidence in helping depressed students (19.9%) and in teaching mental health knowledge to students (11.1%).

Conclusions

MHL in Japanese high school teachers appears to be low. Education programs should be developed and implemented to improve teacher MHL with the aim of helping them to support students suffering from mental health problems.
Paternal and maternal support of moderate-to-vigorous physical activity in children on weekdays and weekends: a cross-sectional study
Authors: An Meijing , Chen Tianjiao , Zhou Qianling , Ma Jun
Published: September 2021

Background

Most studies of associations between parental support behaviours for physical activity (PA) and children’s moderate-to-vigorous physical activity (MVPA) have been conducted in developed countries, and they have focused on maternal or parental support behaviours. Children’s MVPA time (i.e., weekdays vs. weekends) has not been adequately differentiated. This paper investigated the associations of paternal and maternal support behaviours for PA with the proportion of children who met the MVPA recommendations on weekdays and weekends in China.

Methods

Cross-sectional data of 517 father–child dyads and 1422 mother–child dyads were analysed. The children recorded PA diaries on 7 consecutive days to assess their MVPA time. The father or mother completed a questionnaire concerning their support for children’s PA. Multivariate logistic regression was used to investigate the independent effects of paternal and maternal support behaviours for PA on whether children met the MVPA recommendations for weekdays, weekends, and the whole week.

Results

Significantly fewer children met the MVPA recommendations on weekends (37.8%) than on weekdays (62.8%). Higher paternal (odds ratio [OR] = 1.098, 95% confidence interval [CI]: 1.009–1.195) and maternal (OR = 1.076, 95% CI: 1.021–1.134) total support behaviour scores were associated with higher odds of children meeting the MVPA recommendations on weekends, after controlling for covariates. Paternal PA knowledge-sharing with the child was positively associated with children meeting the MVPA recommendations on weekends (OR = 1.319, 95% CI: 1.055–1.649); it tended to be associated with children meeting the MVPA recommendations on weekdays and throughout the week, although these associations were not statistically significant. Maternal reservation of PA time for the child was positively associated with a higher likelihood of children meeting the MVPA recommendations on weekdays (OR = 1.160, 95% CI: 1.025–1.313), weekends (OR = 1.241, 95% CI: 1.097–1.403), and throughout the week (OR = 1.214, 95% CI: 1.076–1.369).

Conclusions

Paternal and maternal support behaviours for PA should be enhanced on weekends to increase children’s MVPA. Fathers should share PA knowledge with children and mothers should reserve PA time for children every day.
Comparing the Interface pressure distribution of the full body chest-lumbar cushion made of memory cotton with the traditional chest cushion
Authors: Zhang Zhiwei , Jiang Zhiqun , Wu Ying , Yan Yu , Chen Weiqiang , Zeng Yu
Published: September 2021

Background

Pressure injuries are common complications occurred duration hospitalization, whether the interface pressure distribution in full body memory cotton chest-lumbar cushion was superior than traditional chest cushion remains unclear.

Purpose

This study aimed to compare the effects that the full body memory cotton chest-lumbar cushion versus traditional chest cushion on interface pressure.

Methods

A total of 66 healthy individuals were recruited. The volunteers were placed in the left lateral position and left armpit and iliac spine pressure and level of comfort were measured. Group differences were assessed using the paired t-test or Wilcoxon test according to data distribution. Additionally, multivariate regression analysis was applied to determine the potential role of sex, age, and body mass index on left armpit and iliac spine pressure and overall comfort.

Results

Compared with the traditional chest cushion, we noted that the full body chest-lumbar cushion made of memory cotton was associated with less pressure on the left armpit (38.17 ± 10.39 mmHg vs. 67.93 ± 14.67 mmHg, respectively; P < 0.0001) and iliac spine (43.32 ± 13.70 mmHg vs. 50.77 ± 20.94 mmHg, respectively; P = 0.0004). Moreover, we noted that the overall comfort with the memory cotton chest-lumbar cushion was higher than that with the traditional chest cushion (8.48 ± 1.08 vs. 6.36 ± 1.45, respectively; P < 0.0001). Finally, the multivariate regression analyses found iliac spine pressure could affect by sex (P = 0.0377) and body mass index (P = 0.0380).

Conclusions

The full body chest-lumbar cushion made of memory cotton had beneficial effects on left armpit and iliac spine pressure and on comfort. These findings should be applied to future clinical practice.
Management of atraumatic shoulder instability in physiotherapy (MASIP): a survey of physiotherapy practice
Authors: Coulthard Caroline , Cairns Mindy C , Williams Deborah , Hughes Ben , Jaggi Anju
Published: September 2021

Background

The impact of atraumatic shoulder instability (ASI) on patients can be extensive, its management complex, with a biopsychosocial approach recommended. Currently how physiotherapists manage ASI is unknown or the extent to which current clinical practice aligns with existing evidence. At the time of this study no national guidelines or consensus to direct practice existed.

Methods

A cross-sectional electronic survey was distributed between July-September 2018, targeting UK-based physiotherapists managing shoulder pathology.

Respondents were invited to describe their management of ASI, and rate their awareness and utilisation of various treatment techniques on a Likert-scale; median and interquartile ranges were calculated. Free text survey items were analysed using quantitative content analysis (QCA) to identify codes and categories. Means and percentages were calculated to summarise QCA and descriptive data.

Results

Valid survey responses were analysed (n = 135). Respondents had between 2 and 39 years of physiotherapy experience (mean = 13.9 years); the majority (71.1 %) reported that ASI made up < 10 % of their caseload. Only 22.9 % (n = 31/135) of respondents reported feeling ‘very confident’ in managing ASI; the majority feeling ‘somewhat confident’ (70.4 %, n = 95/135) or ‘not confident’ (6.7 %, n = 9/135).

The majority of respondents (59.3 %) used an ASI classification system, > 90 % citing the Stanmore Classification. Physiotherapists adapted their management according to clinical presentation, responding to differing biopsychosocial needs of the patient scenario. Most respondents (> 80 %) did not use a protocol to guide their management. Exercise was the most utilised management approach for ASI, followed by education; novel treatment strategies, including cortical rehabilitation, were also reported.

Conclusion

Findings indicate physiotherapists utilise a wide range of treatment strategies and respond to biopsychosocial cues when managing patients with ASI. The majority reported not being very confident in managing this condition, however only a minority use rehabilitation protocols to support their management. Some interventions that respondents reported using lacked evidence to support their use in ASI management and further research regarding effectiveness is required. Guidelines have been published since this survey; the impact of these will need evaluating to determine their effectiveness in the future.
Hydroxyapatite-coated cementless total hip arthroplasty for patients undergoing dialysis: a study of 30 hips with a minimum follow-up period of 5 years
Authors: Hashimoto Akira , Sonohata Motoki , Kii Sakumo , Kawano Shunsuke , Mawatari Masaaki
Published: September 2021

Background

The number of total hip arthroplasties (THAs) performed for patients undergoing dialysis is increasing. However, there are few reports of cementless THA for patients undergoing dialysis. This study investigated the mid-term to long-term results of hydroxyapatite (HA)-coated cementless THA for dialysis patients.

Methods

This single-center, retrospective study enrolled dialysis patients undergoing primary HA-coated cementless THA. A total of 24 patients (30 hips) were included in the final analyses. The Harris hip score and radiographic results were assessed preoperatively and during the final follow-up examination. Postoperative complications and mortality rates were recorded. The mean follow-up period was 109 months (range, 60–216 months).

Results

The total Harris hip score significantly improved from 40 to 84 points. The overall cumulative survival rates with revision as the endpoint were 100% at 5 years and 90.4% at both 10 and 15 years. Stress shielding was observed in 24 hips (80%). No deaths were related to the primary THA. Complications included periprosthetic fracture for one patient (3.3%), blood transfusion for nine patients (30%), shunt blockage for two patients (6.7%), deep infection for one patient (3.3%), and dislocation for two patients (6.7%).

Conclusions

HA-coated cementless THA resulted in good mid-term outcomes for patients undergoing dialysis with no mortality risk. However, the procedure involved a relatively high perioperative risk of blood transfusion.
Quercetin promotes bone marrow mesenchymal stem cell proliferation and osteogenic differentiation through the H19/miR-625-5p axis to activate the Wnt/β-catenin pathway
Authors: Bian Wei , Xiao Shunqiang , Yang Lei , Chen Jun , Deng Shifang
Published: September 2021

Background

Quercetin and H19 can promote osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). However, whether quercetin regulates H19 expression to promote osteogenic differentiation of BMSCs is unclear.

Methods

BMSC proliferation, matrix mineralization, and alkaline phosphatase (ALP) activity were assessed using the Cell Counting Kit-8, ALP assay kit, and alizarin red staining kit, respectively. Expression of H19, miR-625-5p, BMP-2, osteocalcin, and RUNX2 were measured by qRT-PCR; β-catenin protein level was measured by western blotting.

Results

Quercetin promoted BMSC proliferation, enhanced ALP activity, and upregulated the expression of BMP-2, osteocalcin, and RUNX2 mRNAs, suggesting that it promoted osteogenic differentiation of BMSCs. Moreover, quercetin increased H19 expression, while the effect of quercetin on BMSCs was reversed by silencing H19 expression. Additionally, miR-625-5p, interacted with H19, was downregulated during quercetin-induced BMSC osteogenic differentiation, which negatively correlated with H19 expression. Silencing miR-625-5p expression promoted BMSC proliferation and osteogenic differentiation, whereas miR-625-5p overexpression weakened the effect of quercetin on BMSCs. Finally, quercetin treatment or downregulation of miR-625-5p expression increased β-catenin protein level in BMSCs. Upregulation or downregulation of miR-625-5p or H19 expression, respectively, inhibited β-catenin protein level in quercetin treated-BMSCs.

Conclusion

H19 promotes, while miR-625-5p inhibits BMSC osteogenic differentiation. Quercetin activates the Wnt/β-catenin pathway and promotes BMSC osteogenic differentiation via the H19/miR-625-5p axis.