bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrating network pharmacology and experimental verification to explore the mechanism of puerarin against oliguria in acute alcoholism
Authors: Wan Mei-Xuan , Huang Xian-Jun , Li Xue , Suan Juan , Xu Li
Published: October 2022

Purpose: This study was designed to evaluate the pharmacological mechanisms of puerarin against oliguria in acute alcoholism via network pharmacology analysis combined with experimental verification.

Methods: First, this study established an acute alcoholism rat model, compared the changes in urine volume in each group, and observed the therapeutic effect of puerarin by H&E staining, biochemical, RT-qPCR, and immunohistochemical analyses. Second, puerarin-related targets were searched in TCMS, PubChem, CNKI, Wanfang, PubMed, and GeenMedical Academic databases. Also, potential disease targets were obtained from the GeneCards, MalaCards, and NCBI-gene databases and genes with puerarin target gene intersections were screened out. The interaction network for co-predicted targets was obtained using the STRING database, and the core targets were imported into Cytoscape for visualization using DAVID Bioinformatics Resources 6.8. The essential genes were subjected to the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) pathway enrichment analyses to predict related biological processes and significant signaling pathways. Finally, molecular docking was used to examine the interaction of puerarin with key targets, and the core targets were validated further by RT-qPCR and Western blotting.

Results: Compared to the model group, the urine volume of the rats was significantly increased after puerarin treatment, and the levels of anti-diuretic hormone (ADH) and aquaporin 2 (AQP2) expression were decreased. Searching the intersection of puerarin and acute alcoholism targets yielded 214 potential targets, 837 biological processes, and 185 signaling pathways involved. The molecular docking results indicated a good affinity between puerarin and key targets (cyclic adenosine monophosphate (cAMP), protein kinase A (PKA), cAMP-response element-binding protein (CREB), and c-Fos). RT-qPCR and Western blotting further verified that puerarin could down-regulate the expression of cAMP/PKA/CREB/c-Fos.

Conclusion: This study identified the potential targets of puerarin against oliguria in rats with acute alcoholism using network pharmacology and animal experiments. The mechanism may be closely related to the cAMP signaling pathway.
Administration of recombinant human thrombopoietin is associated with alleviated thrombocytopenia in adult intensive care unit patients with pneumonia: A single-center retrospective study
Authors: Chen Bailiang , Xuan Jiabin , Wu Feng , Shi Nengxian , Dai Jianwei , Cai Shumin , An Shengli , Huang Qiaobing , Huang Xiaoling , Chen Zhongqing , Zeng Zhenhua
Published: October 2022

Background: Recombinant human thrombopoietin (rhTPO) is reported to stimulate platelet production and increase peripheral platelet counts; it is primarily used to manage chemotherapy-induced thrombocytopenia and idiopathic thrombocytopenic purpura. However, the effect of rhTPO in patients with pneumonia and thrombocytopenia remains uncertain.

Objective: To assess the association of rhTPO and platelet counts in ICU patients with pneumonia and thrombocytopenia.

Materials and Methods: A retrospective cohort study was performed in the ICU department, Nanfang Hospital, Southern Medical University, Guangzhou, China. From January 2016 to April 2021, patients with pneumonia and thrombocytopenia were allocated to two groups—the rhTPO and no-rhTPO groups—according to whether they received rhTPO treatment or not during their ICU stay. Demographical and clinical data were collected and analyzed using statistical software; p < 0.05 was considered statistically significant.

Results: Out of 327 patients, 149 were in the rhTPO group and 178 were in the no-rhTPO group. Within the first 7 days, platelet counts increased more for patients in the rhTPO group compared with those in the no-rhTPO group (99.21 ± 102.613 vs. 2.08 ± 43.877, p = 0.000). The clinical recovery rate of platelets increased within 7 days (65.8 vs. 18.5%, p = 0.000) and, after 7 days of enrollment, hemorrhagic scores decreased more apparently in the rhTPO group (2.81 ± 2.856 vs. 1.16 ± 2.123, p = 0.000). Further, bleeding events ceased in 66.7% of the patients in the rhTPO group compared with 37.3% of the patients in the no-rhTPO group (p = 0.000). Less red-blood-cells transfusions were needed in the rhTPO group (3.639 ± 4.630 vs. 5.818 ± 6.858, p = 0.009). Furthermore, through logistic regression, rhTPO administration was found to be an independent indicator that affected the platelet recovery rate within 7 days.

Conclusion: This study finds that rhTPO administration is associated with increased platelet counts, alleviated bleeding, and reduced blood transfusion. For patients with pneumonia and thrombocytopenia, rhTPO may be an effective therapeutic drug; however, more RCT trails are needed to confirm our observation.
Traditional Chinese medicine for hypertrophic scars—A review of the therapeutic methods and potential effects
Authors: Chen Daqin , Li Qiannan , Zhang Huimin , Kou Fang , Li Qiang , Lyu Chunming , Wei Hai
Published: October 2022

Hypertrophic scar (HS) is a typical pathological response during skin injury, which can lead to pain, itching, and contracture in patients and even affect their physical and mental health. The complexity of the wound healing process leads to the formation of HS affected by many factors. Several treatments are available for HS, whereas some have more adverse reactions and can even cause new injuries with exacerbated scarring. Traditional Chinese Medicine (TCM) has a rich source, and most botanical drugs have few side effects, providing new ideas and methods for treating HS. This paper reviews the formation process of HS, the therapeutic strategy for HS, the research progress of TCM with its relevant mechanisms in the treatment of HS, and the related new drug delivery system of TCM, aiming to provide ideas for further research of botanical compounds in the treatment of HS, to promote the discovery of more efficient botanical candidates for the clinical treatment of HS, to accelerate the development of the new drug delivery system and the final clinical application, and at the same time, to promote the research on the anti-HS mechanism of multiherbal preparations (Fufang), to continuously improve the quality control and safety and effectiveness of anti-HS botanical drugs in clinical application.
Hybrid_DBP: Prediction of DNA-binding proteins using hybrid features and convolutional neural networks
Authors: Yu Shaoyou , Peng Dejun , Zhu Wen , Liao Bo , Wang Peng , Yang Dongxuan , Wu Fangxiang
Published: October 2022

DNA-binding proteins (DBP) play an essential role in the genetics and evolution of organisms. A particular DNA sequence could provide underlying therapeutic benefits for hereditary diseases and cancers. Studying these proteins can timely and effectively understand their mechanistic analysis and play a particular function in disease prevention and treatment. The limitation of identifying DNA-binding protein members from the sequence database is time-consuming, costly, and ineffective. Therefore, efficient methods for improving DBP classification are crucial to disease research. In this paper, we developed a novel predictor Hybrid _DBP, which identified potential DBP by using hybrid features and convolutional neural networks. The method combines two feature selection methods, MonoDiKGap and Kmer, and then used MRMD2.0 to remove redundant features. According to the results, 94% of DBP were correctly recognized, and the accuracy of the independent test set reached 91.2%. This means Hybrid_ DBP can become a useful prediction tool for predicting DBP.
Epigallocatechin-3-gallate Mo nanoparticles (EGM NPs) efficiently treat liver injury by strongly reducing oxidative stress, inflammation and endoplasmic reticulum stress
Authors: Yang Yunrong , Liu Min , Zhao Tianjiao , Chen Qiaohui , Yang Yuqi , Wang Shuya , Zhang Jinping , Deng Guiming , Sun Kewei , Nan Yayun , Cao Ke , Ai Kelong , Huang Qiong
Published: October 2022

Drug-induced liver injury (DILI) is a serious clinical disease associated with reactive oxygen species (ROS) burst and subsequent inflammatory responses. However, traditional treatments were limited by low efficacy and serious side effects due to the special liver structure. Here, we developed a molybdenum (Mo)-based nanoparticles, EGM NPs, after overall consideration of the pathophysiology of DILI and the advantages of nanodrugs. It demonstrated that EGM NPs treated acetaminophen (APAP)-induced DILI by scavenging ROS and inhibiting inflammation. EGM NPs effectively scavenged various ROS and reduced cell apoptosis at the cellular level. More importantly, EGM NPs can treat APAP-induced DILI in vivo, reducing the levels of liver function indicators in mice with liver injury, scaling down the area of hepatocyte necrosis and successfully inhibiting endoplasmic reticulum (ER) stress in the liver. EGM NPs also showed a certain anti-inflammatory effect by reducing infiltration of macrophages, decreasing pro-inflammatory factors and inhibiting the expression levels of inducible nitric oxide synthase (NOS2) and myeloperoxidase (MPO). Collectively, our findings suggest that EGM NPs-based nanotherapeutic is a novel strategy for the treatment of DILI.
A chinese medicine formula (kunbixiao granule) for female rheumatoid arthritis: Study protocol for a double-blind, randomized, placebo-controlled trial
Authors: Wan Yingying , Yang Jiaxi , Ma Tianyue , Wang Wenqian , Wang Haonan , Sun Wenting , Ye Wanting , Yang Lin , Kou Qiuai
Published: October 2022

Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting females more than males. Clinical symptoms, disease activity and comorbidities are more severe in females. Moreover, the choice of treatment for females is limited during childbearing age due to the side effects of current drugs. Therefore, developing novel and safer drugs for females is urgently needed. Kunbixiao granules (KBXG), a Chinese medicine formula, has been applied to treat female RA patients in our center as a complementary therapy. However, there is insufficient evidence for its effect. Therefore, we aim to conduct a randomized, controlled, double-blind clinical trial to confirm the efficacy and safety of KBXG for the treatment of female RA.

Methods: This study is a single-center, double-blind, randomized, parallel group, placebo-controlled clinical trial. A total of 90 female RA patients with Disease Activity Score for 28 joints (DAS28) > 3.2 will be enrolled. They will be randomly assigned to receive either KBXG or placebo for 12 weeks. The change in DAS28 based on C-reactive protein (DAS28-CRP) and the Clinical Disease Activity Index (CDAI) are the primary outcomes. The secondary outcomes include a rate of achieving 20%, 50% and 70% improvement in the American College Rheumatology criteria (ACR20, ACR50, ACR70), TCM syndrome score, visual analogue scale (VAS), average hands grip strength, the consumption of concomitant medication, Hospital Anxiety and Depression Scale (HADS), lumbar spine bone mineral density (L-BMD) and 7-joint ultrasound score (US7). Any adverse events will also be recorded.

Discussion: This trial will provide evidence of KBXG in reducing disease activity, and improving clinical symptoms and quality of life of female RA patients. The long-term effects of KBXG on female RA patients still needs a further follow-up.
Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods
Authors: Nicolas Chantel I. , Linakis Matthew W. , Minto Melyssa S. , Mansouri Kamel , Clewell Rebecca A. , Yoon Miyoung , Wambaugh John F. , Patlewicz Grace , McMullen Patrick D. , Andersen Melvin E. , Clewell III Harvey J.
Published: October 2022

Current computational technologies hold promise for prioritizing the testing of the thousands of chemicals in commerce. Here, a case study is presented demonstrating comparative risk-prioritization approaches based on the ratio of surrogate hazard and exposure data, called margins of exposure (MoEs). Exposures were estimated using a U.S. EPA’s ExpoCast predictive model (SEEM3) results and estimates of bioactivity were predicted using: 1) Oral equivalent doses (OEDs) derived from U.S. EPA’s ToxCast high-throughput screening program, together with in vitro to in vivo extrapolation and 2) thresholds of toxicological concern (TTCs) determined using a structure-based decision-tree using the Toxtree open source software. To ground-truth these computational approaches, we compared the MoEs based on predicted noncancer TTC and OED values to those derived using the traditional method of deriving points of departure from no-observed adverse effect levels (NOAELs) from in vivo oral exposures in rodents. TTC-based MoEs were lower than NOAEL-based MoEs for 520 out of 522 (99.6%) compounds in this smaller overlapping dataset, but were relatively well correlated with the same (r2 = 0.59). TTC-based MoEs were also lower than OED-based MoEs for 590 (83.2%) of the 709 evaluated chemicals, indicating that TTCs may serve as a conservative surrogate in the absence of chemical-specific experimental data. The TTC-based MoE prioritization process was then applied to over 45,000 curated environmental chemical structures as a proof-of-concept for high-throughput prioritization using TTC-based MoEs. This study demonstrates the utility of exploiting existing computational methods at the pre-assessment phase of a tiered risk-based approach to quickly, and conservatively, prioritize thousands of untested chemicals for further study.
Are the antagonist muscle fatigued during a prolonged isometric fatiguing elbow flexion at very low forces for young adults?
Authors: Wang Lejun , Song Xiaoqian , Yang Hua , Wang Ce , Shao Qineng , Tao Haifeng , Qiao Minjie , Niu Wenxin , Liu Xiaodong
Published: October 2022

The aim of this study was to examine whether antagonist muscles may be fatigued during a prolonged isometric fatiguing elbow flexion at very low forces. Twelve healthy male subjects sustained an isometric elbow flexion at 10% maximal voluntary contraction torque until exhaustion while multichannel electromyographic signals were collected from the biceps brachii (BB) and triceps brachii (TB). Muscle fiber conduction velocity (CV) and fractal dimension (FD) of both muscles were calculated to reflect peripheral and central fatigue. CV and FD of TB as well as FD of BB decreased progressively during the sustained fatiguing contraction, while the CV of BB declined at the beginning of the contraction and then increased progressively until the end of the contraction. The result may indicate that during the sustained low-force isometric fatiguing contraction, antagonist muscle may be peripherally fatigued, and changes in coactivation activities were modulated not only by central neuronal mechanisms of common drive but also by peripheral metabolic factors.
Effect of 3 min whole-body and lower limb cold water immersion on subsequent performance of agility, sprint, and intermittent endurance exercise
Authors: Zhang Wei , Ren Shoupeng , Zheng Xinyan
Published: October 2022

The aim of this study was to investigate the effects of whole-body cold-water immersion (WCWI) and lower-limb cold-water immersion (LCWI) employed during a 15-min recovery period on the subsequent exercise performance as well as to determine the physiological and perceptual parameters in the heat (39°C). Eleven males performed team-sports-specific tests outdoors. The exercise program consisted of two identical exercise protocols (1 and 2) separated by a 15-min recovery period. The participants completed the same tests in each exercise protocol, in the following order: agility t test (t-test), 20-m sprint test (20M-ST), and Yo-Yo Intermittent Endurance Test Level 1 (Yo-Yo). During the recovery period, a 3-min recovery intervention of a passively seated rest (control, CON), WCWI, or LCWI was performed. The t-test and 20M-ST for the CON group were significantly longer during exercise protocol 2, but they were not significantly different between the two exercise protocols for the WCWI and LCWI groups. The completed Yo-Yo distance for the CON and LCWI groups was shorter during exercise protocol 2, but it was not significantly different between the two exercise protocols for the WCWI group. The chest temperature (Tchest), upper arm temperature (Tarm), thigh temperature (Tthigh), mean skin temperature (Tskin), and thermal sensation (TS) values were lower for the WCWI group than for the CON group; but only the Tthigh, Tskin, and TS values were lower for the LCWI group compared to the CON group. The Tchest, Tarm, Tskin, and TS values after the intervention were lower for the WCWI group than for the LCWI group. None of the three intervention conditions affected the core temperature (Tcore), heart rate (HR), or rating of perceived exertion (RPE). These results suggest that WCWI at 15°C for 3 min during the 15-min recovery period attenuates the impairment of agility, sprint, and intermittent-endurance performance during exercise protocol 2, but LCWI only ameliorates the reduction of agility and sprint performance. Furthermore, the ergogenic effects of WCWI and LCWI in the heat are due, at least in part, to a decrease of the Tskin and improvement of perceived strain.
Single and interactive effects of variables associated with climate change on wheat metabolome
Authors: Večeřová Kristýna , Oravec Michal , Puranik Swati , Findurová Hana , Veselá Barbora , Opoku Emmanuel , Ofori-Amanfo Kojo Kwakye , Klem Karel , Urban Otmar , Sahu Pranav Pankaj
Published: October 2022

One of the key challenges linked with future food and nutritional security is to evaluate the interactive effect of climate variables on plants’ growth, fitness, and yield parameters. These interactions may lead to unique shifts in the morphological, physiological, gene expression, or metabolite accumulation patterns, leading to an adaptation response that is specific to future climate scenarios. To understand such changes, we exposed spring wheat to 7 regimes (3 single and 4 combined climate treatments) composed of elevated temperature, the enhanced concentration of CO2, and progressive drought stress corresponding to the predicted climate of the year 2100. The physiological and metabolic responses were then compared with the current climate represented by the year 2020. We found that the elevated CO2 (eC) mitigated some of the effects of elevated temperature (eT) on physiological performance and metabolism. The metabolite profiling of leaves revealed 44 key metabolites, including saccharides, amino acids, and phenolics, accumulating contrastingly under individual regimes. These metabolites belong to the central metabolic pathways that are essential for cellular energy, production of biosynthetic pathways precursors, and oxidative balance. The interaction of eC alleviated the negative effect of eT possibly by maintaining the rate of carbon fixation and accumulation of key metabolites and intermediates linked with the Krebs cycle and synthesis of phenolics. Our study for the first time revealed the influence of a specific climate factor on the accumulation of metabolic compounds in wheat. The current work could assist in the understanding and development of climate resilient wheat by utilizing the identified metabolites as breeding targets for food and nutritional security.
Optimization and validation of blade parameters for inter-row weeding wheel in paddy fields
Authors: Zhang Yongzheng , Tian Liang , Cao Chengmao , Zhu Chengliang , Qin Kuan , Ge Jun
Published: October 2022

The performance of existing rice-paddy weeding machines is not optimal. In this study, the influence of the installation angle of the weeding-wheel blade on cutting resistance and soil-slippage ability was analyzed. The optimal blade angle of the weeding wheel (i.e., the angle at which the resistance to the weeding wheel is minimal and the disturbance speed of the soil maximal) was shown to be< 20°; numerical simulation showed the actual optimal value to be 0°. Different weeding depths (30, 40, and 50 mm), rotation speed of weeding wheel (120, 180, and 240 r/min), and weeder forward speeds (0.3, 0.6, and 0.9 m/s) were used as test factors, and the rates of seedling injury and weeding were used as performance-evaluation criteria to optimize the machine in a secondary orthogonal-rotation combination test. Field experiments showed that the weeding wheel can exhibit optimal working performance under the operating conditions of weeding depth of 39 mm, rotation speed of 175 r/min, and forward speed of 0.6 m/s. The seedling injury and weeding rates were 4.4% and 88.2%, respectively, which were consistent with the numerically predicted results and met the agronomic requirements. This study provides a technical reference for the improvement of paddy-field weeding components.
Grapevine leaf MALDI-MS imaging reveals the localisation of a putatively identified sucrose metabolite associated to Plasmopara viticola development
Authors: Maia Marisa , McCann Andréa , Malherbe Cédric , Far Johann , Cunha Jorge , Eiras-Dias José , Cordeiro Carlos , Eppe Gauthier , Quinton Loïc , Figueiredo Andreia , De Pauw Edwin , Sousa Silva Marta
Published: October 2022

Despite well-established pathways and metabolites involved in grapevine-Plasmopara viticola interaction, information on the molecules involved in the first moments of pathogen contact with the leaf surface and their specific location is still missing. To understand and localise these molecules, we analysed grapevine leaf discs infected with P. viticola with MSI. Plant material preparation was optimised, and different matrices and solvents were tested. Our data shows that trichomes hamper matrix deposition and the ion signal. Results show that putatively identified sucrose presents a higher accumulation and a non-homogeneous distribution in the infected leaf discs in comparison with the controls. This accumulation was mainly on the veins, leading to the hypothesis that sucrose metabolism is being manipulated by the development structures of P. viticola. Up to our knowledge this is the first time that the localisation of a putatively identified sucrose metabolite was shown to be associated to P. viticola infection sites.
Hypovirulence caused by mycovirus in Colletotrichum fructicola
Authors: Guo Jun , Zhou Xinyu , Xie Fangling , Cao Junjie , Liu Shuangqing , Zhong Jie , Zhu Hongjian
Published: October 2022

Colletotrichum fructicola is a pathogenic fungus causing leaf black spot and fruit rot disease in a wide variety of crops. Some mycoviruses that cause detrimental effects on fungal hosts could be useful in studying the pathogenesis of fungal hosts. In this study, we reported two mycoviruses, Colletotrichum fructicola ourmia-like virus 1- Colletotrichum gloeosporioides ourmia-like virus 1 (CfOLV1-CgOLV1) and Colletotrichum fructicola ourmia-like virus 2 (CfOLV2), from a C. fructicola fungus. The complete genome sequences of CfOLV1-CgOLV1 and CfOLV2 contain 2,516 bp and 2,048 bp, respectively. Both of these viruses contain only one open reading frame (ORF), which encodes an RNA-dependent RNA polymerase (RdRp). CfOLV1-CgOLV1 was identical as the previously reported virus CgOLV1. Phylogenetic analysis showed that CfOLV2 is closely related to Scleroulivirus and Magoulivirus in the family Botourmiaviridae. Virus elimination and horizontal transmission experiments proved that the associated mycoviruses could reduce the pathogenicity of the host C. fructicola. In addition, we found that the virus-containing strains showed a much higher percentage of appressorium formation and more melanin production compared to isogenic virus-free strain, and the presence of the virus is detrimental to the growth of host fungi and regulates the integrity of the cell wall. Transcriptomic analysis showed that mycovirus infection caused various abnormal genes expression in C. fructicola. To the best of our knowledge, this is the first report of a hypovirulence-associated ourmia-like mycovirus in C. fructicola.
Current advances in seagrass research: A review from Viet Nam
Authors: Nguyen Xuan-Vy , Phan Thi Thuy Hang , Cao Van-Luong , Nguyen Nhat Nhu-Thuy , Nguyen Trung-Hieu , Nguyen Xuan-Thuy , Lau Va-Khin , Hoang Cong-Tin , Nguyen-Thi My-Ngan , Nguyen Hung Manh , Dao Viet-Ha , Teichberg Mirta , Papenbrock Jutta
Published: October 2022

Seagrass meadows provide valuable ecosystem services but are fragile and threatened ecosystems all over the world. This review highlights the current advances in seagrass research from Viet Nam. One goal is to support decision makers in developing science-based conservation strategies. In recent years, several techniques were applied to estimate the size of seagrass meadows. Independent from the method used, there is an alarming decline in the seagrass area in almost all parts of Viet Nam. Since 1990, a decline of 46.5% or 13,549 ha was found. Only in a few protected and difficult-to-reach areas was an increase observed. Conditions at those sites could be investigated in more detail to make suggestions for conservation and recovery of seagrass meadows. Due to their lifestyle and morphology, seagrasses take up compounds from their environment easily. Phytoremediation processes of Thalassia hemprichii and Enhalus acoroides are described exemplarily. High accumulation of heavy metals dependent on their concentration in the environment in different organs can be observed. On the one hand, seagrasses play a role in phytoremediation processes in polluted areas; on the other hand, they might suffer at high concentrations, and pollution will contribute to their overall decline. Compared with the neighboring countries, the total Corg stock from seagrass beds in Viet Nam was much lower than in the Philippines and Indonesia but higher than that of Malaysia and Myanmar. Due to an exceptionally long latitudinal coastline of 3,260 km covering cool to warm water environments, the seagrass species composition in Viet Nam shows a high diversity and a high plasticity within species boundaries. This leads to challenges in taxonomic issues, especially with the Halophila genus, which can be better deduced from genetic diversity/population structures of members of Hydrocharitaceae. Finally, the current seagrass conservation and management efforts in Viet Nam are presented and discussed. Only decisions based on the interdisciplinary cooperation of scientists from all disciplines mentioned will finally lead to conserve this valuable ecosystem for mankind and biodiversity.
Phenomenological considerations on empathy and emotions in psychotherapy
Authors: Irarrázaval Leonor , Kalawski Juan Pablo
Published: October 2022

In this article we will present a phenomenological approach to empathy and its relationship with emotions in the context of psychotherapy, highlighting the importance of empathy as a key element of the therapist-client relationship and therapeutic process, regardless of the therapist’s approach. We will use a consensus definition of empathy taken from phenomenologically oriented philosophy to analyze therapist’s empathy, as well as client’s self-empathy and client’s empathic communication with others. We will discuss emotions as they usually manifest in the context of psychotherapy, specifically describing how certain emotions can disturb empathic communication in close personal relationships and how it is possible to reestablish empathic communication in psychotherapy. This article it is not only based on evidence from scientific literature but also incorporates the authors’ practical knowledge of psychotherapy.
Study on a Bayes evaluation of the working ability of petroleum workers in the Karamay region, Xinjiang, China
Authors: An Hengqing , Xu Lei , Liu Yuanyuan , Ma Dongsheng , Zhang Dajun , Tao Ning
Published: October 2022

Objectives

Use Bayes statistical methods to analyze the factors related to the working ability of petroleum workers in China and establish a predictive model for prediction so as to provide a reference for improving the working ability of petroleum workers.

Materials and methods

The data come from the health questionnaire database of petroleum workers in the Karamay region, Xinjiang, China. The database contains the results of a health questionnaire survey conducted with 4,259 petroleum workers. We established an unsupervised Bayesian network, using Node-Force to analyze the dependencies between influencing factors, and established a supervised Bayesian network, using mutual information analysis methods (MI) to influence factors of oil workers’ work ability. We used the Bayesian target interpretation tree model to observe changes in the probability distribution of work ability classification under different conditions of important influencing factors. In addition, we established the Tree Augmented Naïve Bayes (TAN) prediction model to improve work ability, make predictions, and conduct an evaluation.

Results

(1) The unsupervised Bayesian network shows that there is a direct relationship between shoulder and neck musculoskeletal diseases, anxiety, working age, and work ability, (2) The supervised Bayesian network shows that anxiety, depression, shoulder and neck musculoskeletal diseases (Musculoskeletal Disorders, MSDs), low back musculoskeletal disorders (Musculoskeletal Disorders, MSDs), working years, age, occupational stress, and hypertension are relatively important factors that affect work ability. Other factors have a relative impact on work ability but are less important.

Conclusion

Anxiety, depression, shoulder and neck MSDs, waist and back MSDs, and length of service are important influencing factors of work ability. The Tree Augmented Naïve Bayes prediction model has general performance in predicting workers’ work ability, and the Bayesian model needs to be deepened in subsequent research and a more appropriate forecasting method should be chosen.
Empathy development from adolescence to adulthood and its consistency across targets
Authors: Gaspar Augusta , Esteves Francisco
Published: October 2022

This research was conducted with two main goals—to contribute to knowledge on the development of empathy from early adolescence to adulthood, including its contribution to decoding emotion expression, and to improve the understanding of the nature of empathy by simultaneously assessing empathy toward two different targets—humans and animals. It unfolded into two cross-sectional studies: One (S1) obtaining measures of empathy toward humans and animals as targets across five age groups (from pre-adolescents to adults); and another (S2) where a subset of the adolescents who participated in S1 were assessed in emotion expression decoding and subjective and physiological responses to emotional video clips. The results of S1 showed that empathy toward animals and most dimensions of empathy toward humans increase toward adulthood, with important gender differences in empathy to animals and humans, and empathy levels in girls starting off in the age trajectory at higher levels, A moderate correlation between empathy toward human and toward animal targets was also found. S2 showed that the expression of positive emotion is better recognized than that of negative emotion, surprise, or neutral expression, and that the measure of human-directed empathy predicts successful decoding of negative emotion, whereas skin conductance responses (SCRs) and subjective valence ratings predicted successful identification of positive emotion. Gender differences emerged but not across all age groups nor all subscales. Results yield keys to the developmental “pace” and trajectory of the various dimensions of empathy and to how empathy relates to emotion decoding.
The impact of policy perception on technology transfer from boundary-spanning perspective-empirical evidence from Chinese technological enterprises
Authors: Zhang Kaiyun , Wang Qingjin , Wang Xueling , Zhang Fengying
Published: October 2022

Technology transfer is an essential source of technological innovation for enterprises, which is conducive to the market transformation of patent achievements and the commercial application of new technologies. Building upon social capital theory, all data analyses were performed using SPSS 22.0 and Amos software with the multiple linear regression method. The study explores the mechanism of policy perception to obtain the technical resources needed for enterprise development through boundary-spanning behavior, with a moderating effect of inter-organizational trust and technological potential gap. The study uses survey data from 125 enterprise teams of 42 technology-based enterprises in China. The results show that policy perceived usefulness and usability significantly promote technology transfer performance and boundary-spanning behavior plays a mediating role between them. Speaking of the influencing factors of technology transfer, technological potential gap significantly moderates the relationship between boundary-spanning and technology transfer performance. In contrast, inter-organizational trust positively moderates the relationship between boundary-spanning and technology transfer performance. The research provides theoretical reference and guidance for enterprises on using policy perception better to improve technology transfer performance in the institutional environment. It also helps inspire enterprises to better deal with the cooperative relationship between relevant stakeholders and achieve win-win cooperation.
The changes in psychological symptoms of COVID-19 patients after “re-positive”
Authors: Wang Xing , Fan Qinyi , Li Yunyue , Xiao Junjian , Huang Yanyan , Guo Tiantian , Chen Hongguang , Li Mengqian
Published: October 2022

Background

Previous studies have showed that individuals infected with COVID-19 were more likely to report psychological symptoms. However, little is known about the changes from testing positive to negative to positive again.

Methods

This survey was conducted through the questionnaires including the 7-item Generalized Anxiety Disorder (GAD-7), the 9-item Patient Health Questionnaire (PHQ-9), as well as the Self-Rating Scale of Sleep (SRSS) to explore the psychological status of COVID-19 and re-positive cases.

″re-positive″ is defined as a positive RT-PCR test at any time during the recovery period after testing negative.

Results

A total of 94 COVID-19 patients presented the prevalence rates of anxiety, depression, insomnia, and any of the three psychological symptoms being 26.6, 8.6, 12.8, and 31.9%, respectively. Among these, 32 cases were re-tested positive during the recovery period, with the prevalence rates of anxiety, depression, insomnia, and any of the three psychological symptoms being 21.9, 18.7, 31.2, and 37.5%, respectively. The psychological status after re-positive showed a significant decrease in anxiety (P = 0.023), an increase in depression, and a significant rise in insomnia (P = 0.035). For those with no psychological symptoms during initial-positive, after re-positive, 5.88% reported anxiety, 5.88% reported depression, and 11.76% reported insomnia. For those who experienced only anxiety symptoms during initial-positive, after re-positive, 33.3% reported depression, and 33.3% reported insomnia.

Conclusions

Our findings encompassed the urgent concern for anxiety in initial-positive COVID-19 patients, depression in re-positive COVID-19 patients, and insomnia in both initial and re-positive patients, hence enabling targeted interventions for appeasing the psychological burden of COVID-19 patients.
Association of elevated glycated hemoglobin and obesity with afternoon napping for more than 1 h in young and middle-aged healthy adults
Authors: Al-Abri Mohammed A. , Al Lawati Ibtisam , Al Zadjali Fahad
Published: October 2022

Introduction

Sleep has different patterns followed worldwide and can be influenced by social, cultural, and environmental factors. Daytime napping is commonly practiced in different parts of the world with controversial results of its effect on glucose metabolism. The current study aims to examine the association of afternoon napping and night sleep duration with metabolic derangements.

Methods

This is a cross-sectional study involving young adults and middle-aged subjects. Anthropometric measurements were taken for height and weight and hip and waist ratio. Consented subjects were asked to wear actigraphy for 1 week and run their usual daily activities. Home sleep apnea testing was performed to exclude obstructive sleep apnea. Subjects had been asked to come fasting on day seven for blood collection to test for fasting glucose, glycated hemoglobin, lipid profile, and insulin.

Results

A total of 405 subjects were involved to complete the study (52% male, 48% female). The mean age of participants was 32.8 ± 11.5 years. The study indicated that the duration of afternoon napping was significantly associated with abnormal glycated hemoglobin (HbA1c > 5.7%) (p = 0.01) and body mass index (p = 0.046) independent of age, gender, and nocturnal sleep duration. Nocturnal sleep duration was associated with increased insulin level (p = 0.04).

Conclusion

Afternoon napping is associated with an increased level of glycated hemoglobin and obesity and that may predispose to the development of type 2 diabetes mellitus.
Factors influencing the efficiency of cellphone-based CBT for treating sleep disorders
Authors: Hu Nannan , Xu You , Mao Hongjing
Published: October 2022

Objective

This survey aimed to better comprehend the factors influencing patient response to insomnia treatment.

Methods

We conducted an online survey. A total of 1,395 patients completed the questionnaire at baseline. Insomnia, anxiety and depressive symptoms were evaluated using the Pittsburgh Sleep Quality Index (PSQI), 7-item Generalized Anxiety Disorder assessment (GAD-7) and 9-item Patient Health Questionnaire (PHQ-9), respectively. A total of 488 patients completed at least two surveys (baseline and monthly surveys thereafter) and reported that the online CBT was effective at the 1-year follow-up. The 488 patients were divided into three groups: the rapid (treatment effective at 4 weeks), intermediate (4–16 weeks), and delayed-response group (over 16 weeks).

Results

Analysis of the demographic characteristics of the 488 patients did not reveal significant sex differences among the three groups (P = 0.111). However, the groups significantly differed in age (P = 0.001) and education (P = 0.006). Compared to the rapid response group, the delayed-response group had a higher mean age (P < 0.01) and a slightly lower level of education. The duration of the disorder was longer in the delayed-response group. Multivariate logistic regression showed that male sex, junior high school education, and higher PSQI were independent risk factors for the delayed response to treatment.

Conclusion

Many factors affected the efficiency of insomnia treatment. Male sex, junior school education, and a high PSQI score predicted delayed response to insomnia treatment.
A historical review of performance appraisal of public hospitals in China from the perspective of historical institutionalism
Authors: Li Yaqing , He Wensheng , Yang Li , Zheng Keshuang
Published: October 2022

The government performance appraisal of public hospitals serves as an effective management tool to promote high-quality development. It is also an important means of realizing the “Healthy China” initiative. Since the founding of the People's Republic of China, changes in performance appraisal have been divided into the following four periods: the early stage of performance appraisal (1949–1977), the exploration period (1978–2008), the development period (2009–2018), and the integration period (2019–present). This clarifies the regional practice of public hospital performance and identifies the institutional factors of the evolution. It also demonstrates that administrative forces, market-driving forces, and mission-driving forces combine to bring about change in the public hospital performance appraisal system. However, problems such as insufficient application of performance appraisal and coordination between health administrative departments and medical insurance departments still loom large.
Parental smoking exposure before and during pregnancy and offspring attention-deficit/hyperactivity disorder risk: A Chinese child and adolescent cohort study
Authors: Liu Dong , Ren Yaping , Wu Tianfeng , Shen Huiping , Yan Peijing , Meng Yu , Zhang Qianlong , Zhang Jun , Bai Pinqing , Zhao Jian
Published: October 2022

Background

Previous studies revealed that maternal smoking exposure during pregnancy was an essential risk factor for offspring developing attention-deficit/hyperactivity disorder (ADHD). The impact of paternal smoking exposure 1 year before pregnancy on offspring ADHD risk is still unclear.

Methods

The present study included 2,477 school-age children and their parents from the Shanghai Child and Adolescent Health Cohort who had complete data for offspring ADHD diagnosis and parents' smoking exposure before and during pregnancy information. A multivariate logistic regression model and Firth's logistic regression model were used to determine the associations of paternal smoking and parental smoke exposure patterns before and during pregnancy with offspring ADHD risk.

Results

Children whose fathers smoked before pregnancy had a higher risk of developing ADHD [odds ratio (OR) = 2.59, 95% confidence interval (CI): 1.35–4.98] compared to those whose fathers had never been exposed to smoking. Similarly, parents who were exposed to smoking or second-hand smoke before pregnancy had 1.96 times (OR = 1.96, 95% CI: 1.19–3.22) more likely to have offspring with ADHD. Moreover, children whose parents were exposed to smoking both before and during pregnancy were 2.01 times (OR = 2.01, 95% CI: 1.29–3.12) more likely to develop ADHD.

Conclusion

Paternal smoking before pregnancy and parental smoking exposure 1 year ahead of and throughout pregnancy were all risk factors for offspring developing ADHD.
Screen time and myopia: A serial multiple mediator SEM analysis
Authors: Xie Jinchen , Lu Chuntian , Zhu Jie
Published: October 2022

Background

COVID-19 has influenced education systems worldwide, and significantly increased screen time for college students, posing a potential risk of myopia. In China, ninety percent of college students suffer from myopia. Excessive screen time changes college students' lifestyles, imposes potential health risks, and affects opportunities for employment. It is important to identify the potential correlation between screen time use and myopia among college students.

Methods

This paper conducted a nationwide experiment using Chinese college students and set a multiple-mediator SEM model to analyze the potential correlation between screen time and myopia. The two mediators were sedentary behavior and physical activity, respectively.

Results

We obtained three valuable conclusions as follows: First, there was no significant direct relationship between screen time and myopia among Chinese college students during the COVID-19 pandemic. Second, sedentary behavior and physical activity significantly predicted the increase/decrease of myopia among Chinese college students, respectively. Third, a serial multiple mediator that encompassed sedentary behavior and physical activity sequentially fully mediated the relationship between screen time and myopia.

Conclusions

Although there was no directly significant relationship between screen time and myopia, screen time can indirectly influence the risk of suffering myopia by influencing sedentary behavior and physical activity. Our study demonstrates the need to prevent the potential influence of overuse of electronic devices on myopia in college students, especially during the COVID-19 pandemic.
Attitude and influencing factors of patients with schizophrenia toward long-acting injections: A community-based cross-sectional investigation in China
Authors: Sun Yiying , Tong Jie , Feng Ying , Fang Haiping , Jiang Tao , Zhao Liping , Wang Qiang , Yang Yi
Published: October 2022

Background

Low prescription rates of antipsychotic long-acting injections (LAIs) may be a major challenge in the prevention and treatment of schizophrenia. However, there are few studies on the usage and attitude toward LAIs among community-based patients with schizophrenia.

Methods

A large community-based cross-sectional investigation was conducted among 6,336 patients with schizophrenia from Shanghai, China from March 1 to June 30, 2021. The structured Attitude and Status toward Treatment of Community Patients with Schizophrenia Questionnaire (AST-CSQ) was used to investigate the attitude and influencing factors of community-dwelling patients with schizophrenia toward LAIs.

Results

Among the 6,336 participants, the average age was 49.28 ± 11.23. The rate of agreement to LAI antipsychotics among participants was 3.16% (n = 200). The family financial resources, care ability, and disease course of the LAIs group were less than those of the non-LAIs group. However, the LAIs group had higher immediate family guardianship, social activity, previous hospitalization, number of hospitalization, outpatient adherence, previous antipsychotic use, antipsychotic adherence, and attitude toward oral antipsychotics than the non-LAIs group, with significant differences between the two groups (p < 0.05). Furthermore, age (β = −0.036, OR 0.964, 95% CI 0.947–0.982), marital status (β = 0.237, OR 1.267, 95% CI 1.002–1.602), care ability (β = 0.709, OR 2.032, 95% CI 1.437–2.875), outpatient adherence (β = −0.674, OR 0.510, 95% CI 0.358–0.725), antipsychotic adherence (β = 0.920, OR 2.509, 95% CI 1.092–5.764), and attitude toward oral antipsychotics (β = −1.357, OR 0.258, 95% CI 0.103–0.646) were significant predictors of attitude toward LAI antipsychotics (p < 0.05).

Conclusions

The community-dwelling patients with schizophrenia in China had a low willingness to use LAIs. Patients of a younger age, more hospitalizations, and a shorter course of disease were prone to be more willing to accept LAIs. The patients' age, marital status, care ability, outpatient adherence, antipsychotic adherence, and attitude toward oral antipsychotics were important predictor of patients' attitudes toward LAIs. Under the global deinstitutionalized management model of mental disorders, these results highlight an urgent problems for public mental health service providers and policy-makers and provide more solutions for them.
Effects of childcare disagreement with children, social support, and health status on unmet healthcare-seeking behavior among the migrant older with children to Jinan, China
Authors: Shi Xinfei , Zong Di , Lu Zhongqian , Li Shixue , Kong Fanlei
Published: October 2022

Due to the acceleration of China's urbanization, the number of migrant older with children (MOC) continued to increase. This study aimed to clarify the effects of childcare disagreement with children, social support, and health status on unmet healthcare-seeking behavior among the MOC to Jinan, China. A cross-sectional study included 656 MOC (36.3% men and 63.7% women) using multi-stage cluster random sampling in Jinan, China. Childcare disagreement was evaluated by the differences between parents and grandparents on the diet, dressing, education, and childcare consumption. Social support was assessed using the social support rating scale (SSRS). Descriptive analysis, chi-squared test, and binary logistic regression were applied to analyze the association between childcare disagreement with children, social support, health status, and unmet healthcare-seeking behavior of the MOC. Approximately 41.3% of participants had unmet healthcare-seeking behavior. Logistic regression analysis showed that the MOC whose health status compared to last year get better were more likely to have unmet healthcare-seeking behavior, while who were women, had partial will of migration, hired a nanny, had smaller childcare disagreement with children on dressing, had smaller childcare disagreement with children on consumption, and had moderate social support, were less likely to experience unmet healthcare-seeking behavior. Recommendations were given to the government and family members to improve the health services-seeking behavior of the MOC.