bluuebunny/crossref_metadata_2025 huggingface dataset:
Motivations for personal financial management: A Self-Determination Theory perspective
Authors: Di Domenico Stefano I. , Ryan Richard M. , Bradshaw Emma L. , Duineveld Jasper J.
Published: September 2022

Financial knowledge and sound financial decision making are now broadly recognized to be important determinants of both personal and societal prosperity, but research has yet to examine how distinct qualities of motivation may be associated with the way people manage their money. In two studies we applied the framework of Self-Determination Theory (SDT) to examine people's autonomous (volitional) and controlled (pressured) motivation for understanding and managing their finances, as well as their amotivation (lack of motivation) for doing so, and the differential associations these motives have with financial knowledge and financial well-being. American participants (Study 1, N = 516; Study 2, N = 534) completed detailed demographic surveys and questionnaires assessing the financial variables of interest. As hypothesized, SDT's motivational constructs were associated with financial outcomes over and above participants' age, gender, income, household wealth, and educational attainment. Autonomous motivation was positively associated with a host of positive financial behaviors and characteristics (e.g., saving/investing and financial self-efficacy, well-being, and self-awareness). Controlled motivation was negatively associated with financial well-being. Amotivation was positively associated with overspending and negatively associated with financial self-efficacy and well-being. These findings support the relevance of SDT's framework in this domain and suggest that interventions aimed at promoting financial knowledge and wellness may benefit by adopting evidence-supported strategies for optimizing more autonomous motivations and addressing amotivations.
Research on commodity business value and customer value of e-commerce platforms: Based on consumer psychology and cognition
Authors: Fu Rong , Zheng Binbin , Wen Juan , Xie Luze
Published: September 2022

Under the background of economic globalization and COVID-19, online shopping has gradually replaced offline shopping as the main shopping mode. In this paper, consumers’ perceptions are introduced into the traditional BCG matrix to form a new BCG matrix, and according to it, the small gifts of a gift e-commerce platform are classified. We then performed a robustness test comparing the BCG matrix with K-means clustering. We found that new BCG matrix can objectively reflect the value of small gifts and provide suggestions for the e-commerce platform to make subsequent product decisions. Then we judge the customer value of the platform based on the improved RFM model and K-means++ clustering, and provide a reasonable customer value classification method for the e-commerce platform. Finally, we comprehensively consider the relationship between the commodity value and customer value, and analyze the preferences of different types of customer groups for different types of small gifts. Our research result shows that small gifts can be divided into 4 categories according to commodity value, namely “stars,” “cash cows,” “questions marks,” and “dogs.” These four categories of small gifts can be converted into each other through marketing ploys. Customers can be divided into important retention customers, key loyal customers and general development customers according to their values. Faced with different types of customers, managers can adopt different strategies to extract customer value. However, consumer psychology will affect consumer cognition, and different types of consumers prefer different types of small gifts, so the precise implementation of marketing strategies will effectively improve the profitability of the gift e-commerce platform. Compared with the traditional classification method, the commodity business value classification method proposed in this paper uses management analysis and planning methods, and introduces consumer psychological factors into the commodity and customer classification, so that the classification results are more credible. In addition, we jointly analyze the results of commodity value classification and customer value classification, and analyze in detail the preferences of different valued customer groups for different types of commodities, so as to provide directions for subsequent research on customer preference.
Effect of Marxist ideological and political education on students’ anxiety in colleges and universities
Authors: Guo Lingxia
Published: September 2022

With the rapid development of China’s economy, politics and culture, the frequency of college students’ anxiety has generally increased. Ideological and political educators in colleges should help college students to relieve anxiety and pressure in a timely manner, and constantly put forward effective and targeted methods. This paper analyzed the reasons for the anxiety of college students from three aspects: the way of dealing with the interpersonal relationship of college students, the degree of emphasis on college students’ academic performance, and the way of college students’ self-decompression. This paper proposed ways to strengthen the ability of thinking, carry out setback education, and improve the psychological quality of college students to realize the Marxist ideological and political education in colleges. This paper mainly used questionnaires and in-depth interviews to analyze the influence of mental health education courses on college students’ anxiety management ability. Among them, after the end of the mental health education course, a questionnaire was distributed to the selected research subjects to understand their stress management ability status after the course. Through the analysis and comparison of the results of the two questionnaires before and after, as well as the comparison of the conventional teaching methods of college students’ mental health education different from the teaching methods of group psychological counseling, it is necessary to understand the way college students’ deal with anxiety. The study found that 19.23% of the students had great anxiety about interpersonal communication problems, and 9.62% of the students reported that they had no major anxiety problems. Therefore, Marxist ideological and political education in colleges has become an important means for college students to vent their emotions, relieve psychological pressure and avoid adverse consequences.
Research trends in college students' sleep from 2012 to 2021: A bibliometric analysis
Authors: Zhou Jingxin , Qu Junchao , Ji Siqi , Bu Yuan , Hu Yicheng , Sun Huiping , Xue Mengxin , Zhou Ting , Qu Jiling , Liu Yongbing
Published: September 2022

Background

A great proportion of college students experience various sleep problems, which damage their health and study performance. College students' sleep problems, which are caused by several factors, have been easily ignored before. In the past decade, more research has been published to expand our understanding of undergraduates' sleep. The purpose of the study is to explore the research hotspots and frontiers regarding college students' sleep using CiteSpace5.8.R3 and offer guidance for future study.

Methods

We retrieved relevant literature from the Web of Science Core Collection Database and imputed the downloaded files into CiteSpace5.8.R3 for visualization analysis. We generated network maps of the collaborations between authors, countries, institutions, the cited journals, and co-occurrence keywords. The analysis of keywords clusters, timeline views, and keywords citation bursts help us identify the hotspots and research trends.

Results

A total of 1,841 articles related to college students' sleep, published from 2012 to 2021, were selected. The number of publications gradually increased. Karl Peltzer was the most prolific authors with 15 publications. The United States and Harvard University separately contributed 680 and 40 articles and had the greatest impact in this field. SLEEP ranked first in the frequency of cited journals. The article published by Lund HG was the most influential publication. Based on the analysis of keywords, we summarized research hotspots as follows: current status, affecting factors, and adverse outcomes of college students' sleep. The frontiers were the further understanding of the relationships between sleep and mental and physical health, and various interventions for sleep disorders.

Conclusion

Our study illustrates the research hotspots and trends and calls for more research to expand the findings. In the future, the cooperation between institutions and authors needs to be strengthened. The complex relationships between sleep and mental and physical health and problematic substance use disorders are necessary to be explored. Longitudinal studies or randomized controlled trials should be constructed to verify the current findings or assumptions.
Heterogeneity of psychosocial functioning in patients with bipolar disorder: Associations with sociodemographic, clinical, neurocognitive and biochemical variables
Authors: Ba Zhengling , Chen Minhua , Lai Jiulan , Liao Yingtao , Fang Hengying , Lu Dali , Zheng Yingjun , Zong Kunlun , Lin Xiaoling
Published: September 2022

Objective

This study aims to identify the functional heterogeneity in fully or partially remitted patients with bipolar disorder and explore the correlations between psychosocial functioning and sociodemographic, clinical, neurocognitive and biochemical variables.

Methods

One hundred and forty fully or partially remitted patients with bipolar disorder (BD) and seventy healthy controls were recruited. The patients were grouped into different profiles based on the Functioning Assessment Short Test (FAST) domain scores by hierarchical cluster analysis. The characteristics of subgroups and the correlations between psychosocial functioning and sociodemographic, clinical, neurocognitive and biochemical variables in each cluster were then analyzed.

Results

There were three subgroups in fully or partially remitted patients with BD: the lower functioning group (LF), performed global functioning impairments; the moderate functioning group (MF), presented selective impairments in functional domains; and the good functioning subgroup (GF), performed almost intact functioning. Among the three subgroups, there were differences in FAST domains, sociodemographic variables, clinical variables, some neurocognitive domains and several biochemical indexes.

Conclusions

The study successfully identified three functional subgroups. The characteristics of discrete subgroups and the specific clinical factors, neurocognitive domains and biochemical indexes that are correlated with functional subgroups will allow for making tailored interventions to promote functional recovery and improve the quality of life.
Basic psychological need satisfaction and frustration in major depressive disorder
Authors: Pietrek Anou , Kangas Maria , Kliegl Reinhold , Rapp Michael A. , Heinzel Stephan , van der Kaap-Deeder Jolene , Heissel Andreas
Published: September 2022

Basic psychological needs theory postulates that a social environment that satisfies individuals’ three basic psychological needs of autonomy, competence, and relatedness leads to optimal growth and well-being. On the other hand, the frustration of these needs is associated with ill-being and depressive symptoms foremost investigated in non-clinical samples; yet, there is a paucity of research on need frustration in clinical samples. Survey data were compared between adult individuals with major depressive disorder (MDD; n = 115; 48.69% female; 38.46 years, SD = 10.46) with those of a non-depressed comparison sample (n = 201; 53.23% female; 30.16 years, SD = 12.81). Need profiles were examined with a linear mixed model (LMM). Individuals with depression reported higher levels of frustration and lower levels of satisfaction in relation to the three basic psychological needs when compared to non-depressed adults. The difference between depressed and non-depressed groups was significantly larger for frustration than satisfaction regarding the needs for relatedness and competence. LMM correlation parameters confirmed the expected positive correlation between the three needs. This is the first study showing substantial differences in need-based experiences between depressed and non-depressed adults. The results confirm basic assumptions of the self-determination theory and have preliminary implications in tailoring therapy for depression.
Levels, trends, and determinants of effectiveness on the hierarchical medical system in China: Data envelopment analysis and bootstrapping truncated regression analysis
Authors: Hou Yuanxin , Tao Wenjuan , Hou Shufen , Li Weimin
Published: September 2022

Background

The hierarchical medical system (HMS) refers to the classification of treatment according to disease priorities based on severity and difficulty to promote the fairness of medical services for residents, which is regarded as the key to the success of medical reform in China.

Methods

In the past decade of “New Medical Reform,” the efficiency of HMS, including secondary and tertiary hospitals and primary healthcare centers (PHCs), was measured horizontally and vertically by employing the combination of an output-oriented superefficiency slack-based model-data envelopment analysis (SE-SBM-DEA) model with the Malmquist total factor productivity index (MTFP). In the second stage, the overall technical efficiency (OTE) scores were regressed against a set of environmental characteristics and several managerial factors through bootstrapping truncated regression.

Results

On average, the OTE score in tertiary hospitals was 0.93, which was higher than that in secondary hospitals and PHCs (0.9 and 0.92, respectively). In terms of trend, the OTE of tertiary hospitals declined at first and then increased. The opposite was true of secondary hospitals, in which the APC of the OTE was 10.82 and −3.11% in early and late 2012, respectively. The PHCs generally showed a fluctuating downward trend. In the aspects of productivity, all institutions showed a downturn by an annual average rate of 2.73, 0.51, and 2.70%, respectively. There was a significant negative relationship between the ratio of outpatients to inpatients and tertiary hospitals. Additionally, the medical technical personnel per 1,000 population negatively affected PHCs. In contrast, the GDP per capita had a significantly positive effect on tertiary hospitals, and the number of beds per 1,000 population positively influenced PHCs.

Conclusion

The efficiency of medical institutions at various levels in HMS was unbalanced and took the form of an “inverted pyramid.” Multilateral factors influence the efficiency of HMS, and to address it, multi-intervention packages focusing on sinking high-quality medical resources and improving healthcare capacity, and guiding hierarchical medical practice should be adopted.
Physicochemical, antioxidant and starch-digesting enzymes inhibitory properties of pearl millet and sweet detar gluten-free flour blends, and sensory qualities of their breads
Authors: Irondi Emmanuel Anyachukwu , Imam Yunus Temitayo , Ajani Emmanuel Oladipo
Published: September 2022

Natural sources of hydrocolloids may serve as healthier alternatives to modified hydrocolloids as gluten replacement in gluten-free food products. In this study, the physicochemical, antioxidant and starch-digesting enzymes inhibitory properties of gluten-free whole pearl millet flour (PMF) blended with 1.5% and 3% of either sweet detar flour (SDF, a natural source of hydrocolloids) or sodium carboxymethyl cellulose (SCMC, a modified hydrocolloid), and the sensory qualities of their breads were evaluated. White wheat flour (WWF) and its bread served as the control flour and bread, respectively. Amylose level and solubility index of the blends decreased, whereas their water absorption capacity, peak and final viscosity increased significantly as their proportions of SDF and SCMC increased. Total phenolics, tannins, and total flavonoids contents; DPPH•, ABTS•+ scavenging capacity, and reducing power; α-amylase and α-glucosidase inhibitory activities were significantly higher in PMF and its blends with SDF and SCMC than in the WWF. Further, the blend of PMF and 1.5% SDF had a stronger α-amylase and α-glucosidase inhibitory activity than those of PMF and SCMC (1.5 and 3%). Although the sensory qualities of the WWF bread were better than those of PMF and its blends with SDF and SCMC, the sensory qualities of PMF-SDF and PMF-SCMC breads were comparable. The study indicates that SDF could be a good substitute for SCMC in the development of PMF-based gluten-free bread, with an enhanced starch-digesting enzymes inhibitory property, targeting celiac disease and type 2 diabetes patients.
Exploring food waste prevention through advent food consumption: The role of perceived concern, consumer value, and impulse buying
Authors: Liao Chuanhui , Qiao Liguang , Wang Xuanzheng , Lu Shanshan
Published: September 2022

Every year, about one-third of food intended for human consumption is wasted along the distribution chain, in which advent food contributes a significant portion. Advent food marketing and consumption are suggested as the primary channel to use advent food and reduce food waste. With the booming of the advent food market, it is necessary to explore factors attributed to advent food purchase and food waste reduction behaviors. This study explored what consumer concern and value might influence food waste reduction intention in the context of advent food consumption. Based on a survey of Chinese consumers (N = 509), this study develops a structural equation and tests the hypotheses with consistent Smart-pls software. Results show that, as expected, health concerns, utilitarian value, and impulse buying significantly affect food waste reduction intention. Price concern, utilitarian value, and hedonic value exert direct positive effects on impulse buying, which negatively influence food waste reduction intention. In the mediating effect analysis, impulse buying partially mediates the relationship between price concern and food waste reduction intention. Theoretical and managerial implications and recommendations for future research are discussed.
Differential proteomic of plasma provides a new perspective on scientific diagnosis and drug screening for dampness heat diarrhea in calves
Authors: Yan Zunxiang , Zhang Kang , Wang Guibo , Wang Lei , Zhang Jingyan , Qiu Zhengying , Guo Zhiting , Zhang Kai , Li Jianxi
Published: September 2022

Dampness heat diarrhea (DHD) is one of the most common syndromes of calf diarrhea. Its complex etiology and lack of objective diagnostic criteria bring great challenges to the diagnosis and treatment of this disease. This study aims to screen some prospective diagnostic biomarkers or therapeutic targets for calves with DHD by investigating the differential protein profiles of plasma between DHD calves and clinically healthy calves by mass spectrometry-based proteomic. A total of 120 DHD calves and 90 clinically healthy calves were divided into two groups randomly, 30 DHD calves and 30 clinically healthy calves in the test group, and 90 DHD calves and 60 clinically healthy calves in the validation group. In the test group, a total of 52 proteins were differentially expressed between calves with DHD and clinically healthy calves, 13 proteins were significantly increased and 39 proteins were significantly decreased. The differentially expressed proteins were associated with the intestinal immune network of IgA production, caffeine metabolism, purine metabolism, and PI3K signaling pathway. In the validation group, 13 proteins were selected from 52 differential expression proteins for parallel reaction monitoring validation to verify their associations with DHD calves. The targeted proteomic results showed that fibronectin precursor (FN1) and apolipoprotein C-IV precursor (APOC4) were significantly associated with DHD in calves, and they were downregulated in sick calves. In conclusion, the differential expression of plasma proteins was associated with DHD pathogenesis in calves, and the FN1 and APOC4 might be the potential clinical biomarkers for diagnosis of DHD in calves, and the intestinal immune network of IgA production, caffeine metabolism, purine metabolism, and PI3K signaling pathway are the candidate targets to treat DHD in calves. Our finding provides a reference for further investigating the pathogenesis, developing techniques of diagnosis, and screening treatment drugs for DHD in calves.
Comparison of the Activity of 3D Binary or Ternary Cobalt Coatings for Hydrogen and Oxygen Evolution Reactions
Authors: Sukackienė Zita , Balčiūnaitė Aldona , Kepenienė Virginija , Vaičiūnienė Jūratė , Stalnionis Giedrius , Pakštas Vidas , Tamašauskaitė-Tamašiūnaitė Loreta , Norkus Eugenijus
Published: September 2022

In this study, cobalt-nickel (Co-Ni), cobalt-iron (Co-Fe), cobalt-iron-manganese (Co-Fe-Mn), cobalt-iron-molybdenum (Co-Fe-Mo), and cobalt-zinc (Co-Zn) coatings were studied as catalysts towards the evolution of hydrogen (HER) and oxygen (OER). The binary and ternary Co coatings were deposited on a copper surface using the electroless metal plating technique and morpholine borane (MB) as a reducing agent. The as-deposited Co-Ni, Co-Fe, Co-Fe-Mn, Co-Fe-Mo, and Co-Zn coatings produce compact and crack-free layers with typical globular morphology. It was found that the Co-Fe-Mo coating gives the lowest overpotential of 128.0 mV for the HER and the lowest overpotential of 455 mV for the OER to achieve a current density of 10 mA cm−2. The HER and OER current density values increase 1.4–2.0 times with an increase in temperature from 25 °C to 55 °C using the prepared 3D binary or ternary cobalt coatings for HER and OER. The highest mass electrocatalytic activity of 1.55 mA µg−1 for HER and 2.72 mA µg−1 for OER was achieved on the Co-Fe coating with a metal loading of 28.11 µg cm−2 at 25 °C.
Detection of SARS-CoV-2 Using Reverse Transcription Helicase Dependent Amplification and Reverse Transcription Loop-Mediated Amplification Combined with Lateral Flow Assay
Authors: Zasada Aleksandra Anna , Mosiej Ewa , Prygiel Marta , Polak Maciej , Wdowiak Karol , Formińska Kamila , Ziółkowski Robert , Żukowski Kamil , Marchlewicz Kasper , Nowiński Adam , Nowińska Julia , Rastawicki Waldemar , Malinowska Elżbieta
Published: September 2022

Rapid and accurate detection and identification of pathogens in clinical samples is essential for all infection diseases. However, in the case of epidemics, it plays a key role not only in the implementation of effective therapy but also in limiting the spread of the epidemic. In this study, we present the application of two nucleic acid isothermal amplification methods—reverse transcription helicase dependent amplification (RT-HDA) and reverse transcription loop-mediated amplification (RT-LAMP)—combined with lateral flow assay as the tools for the rapid detection of SARS-CoV-2, the etiological agent of COVID-19, which caused the ongoing global pandemic. In order to optimize the RT-had, the LOD was 3 genome copies per reaction for amplification conducted for 10–20 min, whereas for RT-LAMP, the LOD was 30–300 genome copies per reaction for a reaction conducted for 40 min. No false-positive results were detected for RT-HDA conducted for 10 to 90 min, but false-positive results occurred when RT-LAMP was conducted for longer than 40 min. We concluded that RT-HDA combined with LFA is more sensitive than RT-LAMP, and it is a good alternative for the development of point-of-care tests for SARS-CoV-2 detection as this method is simple, inexpensive, practical, and does not require qualified personnel to perform the test and interpret its results.
Emerging Roles of TRIM Family Proteins in Gliomas Pathogenesis
Authors: Giannopoulou Angeliki-Ioanna , Xanthopoulos Charalampos , Piperi Christina , Kostareli Efterpi
Published: September 2022

Gliomas encompass a vast category of CNS tumors affecting both adults and children. Treatment and diagnosis are often impeded due to intratumor heterogeneity and the aggressive nature of the more malignant forms. It is therefore essential to elucidate the molecular mechanisms and explore the intracellular signaling pathways underlying tumor pathology to provide more promising diagnostic, prognostic, and therapeutic tools for gliomas. The tripartite motif-containing (TRIM) superfamily of proteins plays a key role in many physiological cellular processes, including brain development and function. Emerging evidence supports the association of TRIMs with a wide variety of cancers, exhibiting both an oncogenic as well as a tumor suppressive role depending on cancer type. In this review, we provide evidence of the pivotal role of TRIM proteins in gliomagenesis and exploit their potential as prognostic biomarkers and therapeutic targets.
A Review on Annona muricata and Its Anticancer Activity
Authors: Ilango Suganya , Sahoo Dipak Kumar , Paital Biswaranjan , Kathirvel Kavibharathi , Gabriel Jerrina Issac , Subramaniam Kalyani , Jayachandran Priyanka , Dash Rajendra Kumar , Hati Akshaya Kumar , Behera Tapas Ranjan , Mishra Pragnyashree , Nirmaladevi Ramalingam
Published: September 2022

The ongoing rise in the number of cancer cases raises concerns regarding the efficacy of the various treatment methods that are currently available. Consequently, patients are looking for alternatives to traditional cancer treatments such as surgery, chemotherapy, and radiotherapy as a replacement. Medicinal plants are universally acknowledged as the cornerstone of preventative medicine and therapeutic practices. Annona muricata is a member of the family Annonaceae and is familiar for its medicinal properties. A. muricata has been identified to have promising compounds that could potentially be utilized for the treatment of cancer. The most prevalent phytochemical components identified and isolated from this plant are alkaloids, phenols, and acetogenins. This review focuses on the role of A. muricata extract against various types of cancer, modulation of cellular proliferation and necrosis, and bioactive metabolites responsible for various pharmacological activities along with their ethnomedicinal uses. Additionally, this review highlights the molecular mechanism of the role of A. muricata extract in downregulating anti-apoptotic and several genes involved in the pro-cancer metabolic pathways and decreasing the expression of proteins involved in cell invasion and metastasis while upregulating proapoptotic genes and genes involved in the destruction of cancer cells. Therefore, the active phytochemicals identified in A. muricata have the potential to be employed as a promising anti-cancer agent.
Splicing Analysis of 16 PALB2 ClinVar Variants by Minigene Assays: Identification of Six Likely Pathogenic Variants
Authors: Valenzuela-Palomo Alberto , Sanoguera-Miralles Lara , Bueno-Martínez Elena , Esteban-Sánchez Ada , Llinares-Burguet Inés , García-Álvarez Alicia , Pérez-Segura Pedro , Gómez-Barrero Susana , de la Hoya Miguel , Velasco-Sampedro Eladio A.
Published: September 2022

PALB2 loss-of-function variants are associated with significant increased risk of breast cancer as well as other types of tumors. Likewise, splicing disruptions are a common mechanism of disease susceptibility. Indeed, we previously showed, by minigene assays, that 35 out of 42 PALB2 variants impaired splicing. Taking advantage of one of these constructs (mgPALB2_ex1-3), we proceeded to analyze other variants at exons 1 to 3 reported at the ClinVar database. Thirty-one variants were bioinformatically analyzed with MaxEntScan and SpliceAI. Then, 16 variants were selected for subsequent RNA assays. We identified a total of 12 spliceogenic variants, 11 of which did not produce any trace of the expected minigene full-length transcript. Interestingly, variant c.49-1G > A mimicked previous outcomes in patient RNA (transcript ∆(E2p6)), supporting the reproducibility of the minigene approach. A total of eight variant-induced transcripts were characterized, three of which (∆(E1q17), ∆(E3p11), and ∆(E3)) were predicted to introduce a premature termination codon and to undergo nonsense-mediated decay, and five (▼(E1q9), ∆(E2p6), ∆(E2), ▼(E3q48)-a, and ▼(E3q48)-b) maintained the reading frame. According to an ACMG/AMP (American College of Medical Genetics and Genomics/Association for Molecular Pathology)-based classification scheme, which integrates mgPALB2 data, six PALB2 variants were classified as pathogenic/likely pathogenic, five as VUS, and five as likely benign. Furthermore, five ±1,2 variants were catalogued as VUS because they produced significant proportions of in-frame transcripts of unknown impact on protein function.
Novel Therapies and Strategies to Overcome Resistance to Anti-HER2-Targeted Drugs
Authors: Gámez-Chiachio Manuel , Sarrió David , Moreno-Bueno Gema
Published: September 2022

The prognosis and quality of life of HER2 breast cancer patients have significantly improved due to the crucial clinical benefit of various anti-HER2 targeted therapies. However, HER2 tumors can possess or develop several resistance mechanisms to these treatments, thus leaving patients with a limited set of additional therapeutic options. Fortunately, to overcome this problem, in recent years, multiple different and complementary approaches have been developed (such as antibody–drug conjugates (ADCs)) that are in clinical or preclinical stages. In this review, we focus on emerging strategies other than on ADCs that are either aimed at directly target the HER2 receptor (i.e., novel tyrosine kinase inhibitors) or subsequent intracellular signaling (e.g., PI3K/AKT/mTOR, CDK4/6 inhibitors, etc.), as well as on innovative approaches designed to attack other potential tumor weaknesses (such as immunotherapy, autophagy blockade, or targeting of other genes within the HER2 amplicon). Moreover, relevant technical advances such as anti-HER2 nanotherapies and immunotoxins are also discussed. In brief, this review summarizes the impact of novel therapeutic approaches on current and future clinical management of aggressive HER2 breast tumors.
Induction of Apoptosis and Effect on the FAK/AKT/mTOR Signal Pathway by Evodiamine in Gastric Cancer Cells
Authors: Yang Ji Yeong , Woo Hyun Jun , Lee Pyeongjae , Kim Sa-Hyun
Published: September 2022

Evodiamine isolated from Evodia rutaecarpa has been known to have anti-tumor activity against various cancer cell types. Although there have been reports showing the inhibitory effect of evodiamine on cell survival of gastric cancer cell, it is not clearly explained how evodiamine affects the expression and modification of proteins associated with apoptosis and upstream signal pathways. We confirmed the cytotoxic activity of evodiamine against AGS and MKN45 cells by a WST assay, cell morphological change, and clonogenic assay. The apoptotic cells were evaluated by Annexin V/PI analysis and Western blot and the expressions of apoptosis-related molecules were confirmed by Western blot. Evodiamine promoted apoptosis of AGS gastric cancer cells through both intrinsic and extrinsic signal pathways in a time- and dose-dependent manner. Evodiamine attenuated the expression of anti-apoptotic proteins, including Bcl-2, XIAP, and survivin, and elevated that of the pro-apoptotic protein Bax. Evodiamine also suppressed the FAK/AKT/mTOR signal pathway. Based on these results, we expect that the results from this study will further elucidate our understanding of evodiamine as an anti-cancer drug.
Mapping and Assessment of Landscape’s Capacities to Supply Ecosystem Services in the Semi-Arid Coast of Brazil—A Case Study of Galinhos-Guamaré Estuarine System
Authors: da Silva Costa Diógenes Félix , Souza Ana Caroline Damasceno , de Souza Pinheiro Lidriana , de Oliveira Alisson Medeiros , da Cruz Guedes Dayane Raquel , Nascimento Douglas Macêdo
Published: September 2022

Wetlands are periodically flooded terrestrial and aquatic environments, which provide benefits to a community known as ecosystem services (ESs). This research identified, classified, and spatialized the level of relevance of ecosystem services provided by wetlands in the Galinhos-Guamaré semi-arid estuarine system, State of Rio Grande do Norte, Northeast Brazil. ESs were analyzed using the Common International Classification of Ecosystem Services (CICES), v.4.3, and geographic information system (GIS) using a mosaic of Sentinel-2A images. The services provided by wetlands were classified into provision, regulation and maintenance, and cultural sections, with six divisions, 12 groups, and 22 classes being identified. The capacity of a number of wetlands to provide services was identified in 34 mangrove forests, 32 estuaries, 30 tidal flats, 26 solar saltworks, 23 apicum (tidal flats), and seven in shrimp ponds. However, it is noteworthy that these habitats are associated with ecosystems with great ecological, socioeconomic, and cultural importance, where the general approach presented here requires more detailed research in each macrohabitat, which should be considered as a priority for conservation.
Numerical Investigation of Inlet Boundary Layer in an Axial Compressor Tandem Cascade
Authors: Yang Zonghao , Liu Bo , Mao Xiaochen , Zhang Botao , Wang Hejian
Published: September 2022

To explore the inlet boundary layer (IBL) influence on the tandem cascade aerodynamic performance, this paper took the high subsonic compressor NACA65 K48 cascade and its modified tandem cascade as the research object. The effects of the IBL thickness and the skewed IBL on the aerodynamic performance of the original cascade and tandem cascade were analyzed based on the numerical method. The results show that the tandem cascade effective design makes it better than the original cascade in the aerodynamic performance under different IBL conditions. Compared with the collateral IBL, the skewed IBL can effectively improve the aerodynamic performance of the original cascade and tandem cascade by suppressing the endwall cross flow, but an increase in the IBL thickness will suppress this advantage. In addition, the increase of incidence angle or the IBL thickness will make the tandem cascade forward blade corner separation more serious and cause the flow passage to be blocked, which seriously affects the rear blade diffusing capacity. In general, the IBL thickness is positively correlated with the tandem cascade total pressure loss and negatively correlated with the static pressure rise (except for the −6° incidence angle). The skewed IBL can effectively reduce the total pressure loss and increase the static pressure rise within −4°~7° incidence angle, but the law is opposite at a −6° incidence angle. At a 0° or 2° incidence angle, the performance improvement effect of the skewed IBL on the tandem cascade is the best, and this positive effect diminishes as it tends towards a larger positive incidence angle or a smaller negative incidence angle.
Propagation of Disturbances Generated by DC Electric Traction
Authors: Olczykowski Zbigniew , Kozyra Jacek
Published: September 2022

In Poland, rail transport is powered by the electric system with the use of traction substations that supply the electric traction with DC voltage of 3 kV. The necessity to change the alternating voltage to the constant and changing loads of the substation cause the electric traction to be a recipient, generating a number of disturbances to the network. These disturbances affect the quality of electricity in the power system from which traction substations are supplied, and the power quality in auxiliary and non-traction lines. This article analyzes the measurements of power quality indicators recorded at selected points of the traction substation system. The parameters characterizing the power quality were recorded, among others, in the main lines supplying traction substations, non-traction lines and auxiliary circuits. The presented article is the first in a series of publications related to the assessment of the impact of DC electric traction on the power system. The recorded data will be the basis for computer simulations defining, inter alia, the impact of power supply conditions for traction substations on the power system and to propose methods of reducing disturbances generated by a dynamically changing substation load.
Wireless Power Transmission System for Powering Rotating Parts of Automatic Machineries
Authors: Kindl Vladimir , Kavalir Tomas , Sika Jiri , Hnatik Jan , Krizek Michal , Frivaldsky Michal
Published: September 2022

This paper deals with the analysis of a suitable compensation topology of a wireless power transmission system for powering the rotating parts of modern automatic machine tools. It summarizes the important properties of the serio-parallel compensation topology suitable for this application and demonstrates a detailed mathematical derivation using the first harmonic approximation. The paper details the industrial implementation of the system in a specific automatic machine tool application and demonstrates the strong technical advantages of the proposed design. Important theoretical conclusions and technical assumptions made when considering the system layout are verified by experimental laboratory measurements and the final deployment of the technology in the professional tool DMU 40 eVo linear.
Machine Learning Applications for the Development of a Questionnaire to Identify Sasang Constitution Typology
Authors: Kim Soon Mi , Ryu Jeongkun , Park Eunhye Olivia
Published: September 2022

Sasang constitutional medicine emphasizes personalized disease prevention and treatment and has been used in various fields. Nevertheless, more efforts are required to improve the validity and reliability of the Sasang analysis tools. Hence, this study aimed to (1) identify key constructs and measurement items of the Sasang constitution questionnaire that characterize different Sasang constitutions and (2) investigate the similarities and differences in pathophysiological and personality traits between Sasang constitutions. The results of the Sasang constitution questionnaire were analyzed using multiple machine learning-based approaches, including feature selection, hierarchical clustering analysis, and multiple correspondence analysis. The selected 47 key measurement items were clustered into six groups based on the similarity measures. The findings of this study are expected to be beneficial for future research on the development of more robust and reliable Sasang conservation questionnaires, allowing Sasang constitutional medicine to be more widely implemented in various sectors.
Genetics, Functions, and Clinical Impact of Presenilin-1 (PSEN1) Gene
Authors: Bagaria Jaya , Bagyinszky Eva , An Seong Soo A.
Published: September 2022

Presenilin-1 (PSEN1) has been verified as an important causative factor for early onset Alzheimer’s disease (EOAD). PSEN1 is a part of γ-secretase, and in addition to amyloid precursor protein (APP) cleavage, it can also affect other processes, such as Notch signaling, β-cadherin processing, and calcium metabolism. Several motifs and residues have been identified in PSEN1, which may play a significant role in γ-secretase mechanisms, such as the WNF, GxGD, and PALP motifs. More than 300 mutations have been described in PSEN1; however, the clinical phenotypes related to these mutations may be diverse. In addition to classical EOAD, patients with PSEN1 mutations regularly present with atypical phenotypic symptoms, such as spasticity, seizures, and visual impairment. In vivo and in vitro studies were performed to verify the effect of PSEN1 mutations on EOAD. The pathogenic nature of PSEN1 mutations can be categorized according to the ACMG-AMP guidelines; however, some mutations could not be categorized because they were detected only in a single case, and their presence could not be confirmed in family members. Genetic modifiers, therefore, may play a critical role in the age of disease onset and clinical phenotypes of PSEN1 mutations. This review introduces the role of PSEN1 in γ-secretase, the clinical phenotypes related to its mutations, and possible significant residues of the protein.
Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Agent for the Treatment of Liver Diseases
Authors: Ding Yi , Luo Qiulin , Que Hanyun , Wang Nan , Gong Puyang , Gu Jian
Published: September 2022

Liver disease has become a major global health and economic burden due to its broad spectrum of diseases, multiple causes and difficult treatment. Most liver diseases progress to end-stage liver disease, which has a large amount of matrix deposition that makes it difficult for the liver and hepatocytes to regenerate. Liver transplantation is the only treatment for end-stage liver disease, but the shortage of suitable organs, expensive treatment costs and surgical complications greatly reduce patient survival rates. Therefore, there is an urgent need for an effective treatment modality. Cell-free therapy has become a research hotspot in the field of regenerative medicine. Mesenchymal stem cell (MSC)-derived exosomes have regulatory properties and transport functional “cargo” through physiological barriers to target cells to exert communication and regulatory activities. These exosomes also have little tumorigenic risk. MSC-derived exosomes promote hepatocyte proliferation and repair damaged liver tissue by participating in intercellular communication and regulating signal transduction, which supports their promise as a new strategy for the treatment of liver diseases. This paper reviews the physiological functions of exosomes and highlights the physiological changes and alterations in signaling pathways related to MSC-derived exosomes for the treatment of liver diseases in some relevant clinical studies. We also summarize the advantages of exosomes as drug delivery vehicles and discuss the challenges of exosome treatment of liver diseases in the future.
Initiation and Withdrawal of Invasive Ventilation for Patients with Amyotrophic Lateral Sclerosis: A Narrative Literature Review
Authors: Ozeki-Hayashi Reina , Nakazawa Eisuke , Truog Robert , Akabayashi Akira
Published: September 2022

Decisions regarding invasive ventilation with tracheostomy (TIV) in patients with amyotrophic lateral sclerosis (ALS) involve serious ethical issues. Cultural differences in the attitudes of patients, caregivers, and physicians toward TIV initiation and withdrawal decisions have been analyzed based on a narrative review approach, comparing the situation between Japan and the U.S. Three main issues were identified regarding the implementation of TIV. The first is the lack of Advance Care Planning. Second, some patients may choose TIV based on the wishes of their physicians or caregivers, even if the patients themselves do not want TIV in the Japanese context. Third is the influence of patient associations, which advocate for the protection of patients’ rights. Next, this study identifies the following issues related to TIV discontinuation. The main concern here is cultural differences in legislation and ethical intuitions regarding the discontinuation of TIV. The treatment guidelines for patients with ALS advise physicians to reassure patients that TIV can be withdrawn at any point. However, TIV withdrawal is not explicitly discussed in Japan. Moreover, Japanese ALS treatment guidelines state that ventilation withdrawal is currently impossible, due to a lack of legal support. Most Japanese physicians have told patients that they are not allowed to stop ventilation via such a request. Unlike in the U.S., withholding and withdrawing ventilators are not ethically equivalent in Japan. In conclusion, the decision-making process regarding TIV is difficult, not only for the patients and caregivers, but also for physicians. Even if patients are legally entitled to refuse unwanted treatment, there have been cases in which Japanese physicians have felt an ethical dilemma in stopping TIV for patients with ALS. However, few studies have investigated in detail why physicians oppose the patient’s right to discontinue TIV in Japan.
Detection of SQL Injection Attack Using Machine Learning Techniques: A Systematic Literature Review
Authors: Alghawazi Maha , Alghazzawi Daniyal , Alarifi Suaad
Published: September 2022

An SQL injection attack, usually occur when the attacker(s) modify, delete, read, and copy data from database servers and are among the most damaging of web application attacks. A successful SQL injection attack can affect all aspects of security, including confidentiality, integrity, and data availability. SQL (structured query language) is used to represent queries to database management systems. Detection and deterrence of SQL injection attacks, for which techniques from different areas can be applied to improve the detect ability of the attack, is not a new area of research but it is still relevant. Artificial intelligence and machine learning techniques have been tested and used to control SQL injection attacks, showing promising results. The main contribution of this paper is to cover relevant work related to different machine learning and deep learning models used to detect SQL injection attacks. With this systematic review, we aims to keep researchers up-to-date and contribute to the understanding of the intersection between SQL injection attacks and the artificial intelligence field.
Collaborative Conservation by Botanical Gardens: Unique Opportunities for Local to Global Impacts
Authors: Raschke Aireona B. , Pegram Kimberly V. , Melkonoff Natalie A. , Davis Jeny , Blackwell Steven A.
Published: September 2022

Conservation organizations with common missions can find strength and synergy in collaboration. Collaboration can also be challenging, especially finding the right partnerships or organizations to lead. Within the “ecosystem” of conservation organizations, botanical gardens have a unique array of resources and expertise which make them ideal candidates for leadership or partnership in collaborative conservation efforts. We will explore this idea by examining four conservation initiatives at Desert Botanical Garden (Phoenix, AZ, USA) that approach collaborative conservation on regional, state, and international scales. On a regional scale, Metro Phoenix EcoFlora and the Central Arizona Conservation Alliance lead landscape-level conservation by providing a structure for more than 60 official conservation partners, by generating data, and through public engagement needed in a rapidly developing region. On the state scale, Great Milkweed Grow Out is an initiative for pollinator conservation that provides expertise, materials, and opportunities for a wide range of partners across Arizona. Desert Botanical Garden’s endangered plant species conservation efforts provide expertise and resources through horticulture and seed preservation for threatened and endangered plants across the US and internationally. We will share the structure of each program where applicable, how they came to fruition, and their successes. Through each case study, we will highlight the ways positioning within a botanical garden has benefitted the program and success in collaboration. We will also highlight unique challenges. Botanical gardens provide unique opportunities, and they should not be overlooked when seeking a conservation partner or leader.