bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGEMBANGAN MODUL IPA STEM MATERI CAHAYA DAN ALAT OPTIK KELAS VIII SMPN 2 KALIANGET
Authors: Sari Fitri Diana , Fajarianingtyas Dyah Ayu , Anekawati Anik
Published: May 2022

Pengembangan modul IPA STEM materi cahaya dan alat optik kelas VIII SMPN 2 kalianget. Penelitian ini memiliki tujuan menentukan validitas bahan ajar mandiri yaitu modul IPA STEM, (2) mendapatkan respon guru dan respon siswa. Subyek menggunakan siswa kelas VIII SMPN 2 Kalianget. Penelitian ini mengacu pada penelitian dan pengembangan 4-D (four D). Data validitas menggunakan analisis Content Validity Index (CVI). Data responden dari unsur guru maupun peserta didik menggunakan analisis angket. Hasil penelitian didapatkan validitas modul IPA STEM materi cahaya serta alat optik kelas VIII dinyatakan valid ditunjukkan dari skor CVI 1,00 (validitas yang sesuai) ditinjau pada aspek materi, bahasa dan media. Hasil respon guru dan siswa berada pada kategori positif. Respon guru yaitu 100%, sedangkan respon siswa yaitu 98,48 % dengan kategori “tercapai”. Hal ini menunjukkan bahwa modul IPA STEM mudah dipahami dan efektif pada kegiatan proses pembelajaran.

Kata kunci: Modul, IPA, STEM, Validitas, Respon

 

ABSTRACT

Development of the STEM science module for light materials and optical instruments for class VIII SMPN 2 Kalianget. This study has the aim of determining the validity of independent teaching materials, namely the STEM Science module, (2) obtaining teacher responses and student responses. The subjects used class VIII SMPN 2 Kalianget students. This research refers to research and development of 4-D (four D). The validity data used Content Validity Index (CVI) analysis. Respondent data from the elements of teachers and students using questionnaire analysis. The results showed that the validity of the STEM science module on light material and optical instruments for class VIII was declared valid, as indicated by a CVI score of 1.00 (appropriate validity) in terms of material, language and media aspects. The results of teacher and student responses are in the positive category. The teacher's response is 100%, while the student's response is 98.48% with the "achieved" category. This shows that the STEM Science module is easy to understand and effective in learning process activities.                                     

Keywords:  Module, IPA, STEM, Validity, Response
PENGEMBANGAN PERANGKAT PEMBELAJARAN IPA BERBANTUAN BUKU PETUNJUK MEDIA PEMBELAJARAN IPA BERBASIS KONTEKSTUAL PESISIR
Authors: Herowati Herowati , Azizah Lutfiana Fazad
Published: May 2022

Pengembangan perangkat pembelajaran IPA berbantuan buku petunjuk media pembelajaran IPA berbasis kontekstual pesisir. Kabupaten Sumenep lebih didominasi oleh wilayah pesisir, sehingga lingkungan pesisir tersebut akan sangat berpotensi apabila dapat dimanfaatkan sebagai media pembelajaran IPA kontekstual. Buku petunjuk media pembelajaran IPA kontekstual yang telah dikembangkan sebelumnya dapat dimanfaatkan dalam penerapan pembelajaran kontekstual. Tujuan penelitian ini adalah untuk menghasilkan perangkat pembelajaran IPA berbantuan buku petunjuk media pembelajaran IPA berbasis kontekstual pesisir. Model penelitian yang digunakan adalah model penelitian pengembangan 4D (four D) yang terdiri dari 4 tahapan yaitu: Define (Pendefinisian), Design (Perancangan), Develope (Pengembangan), dan Disseminate (Penyebaran). Penelitian ini terbatas hanya pada tahap define, design, dan develope. Hasil penelitian yang didapatkan yaitu kelayakan Kelayakan perangkat pembelajaran IPA berbantuan buku petunjuk media pembelajaran IPA berbasis kontekstual pesisir didapatkan dari validasi ahli materi 95,4% dan validasi ahli pembelajaran memperoleh rata-rata persentase 94,3% dengan kategori sangat layak sehingga perangkat pembelajaran IPA berbantuan buku petunjuk media pembelajaran IPA berbasis kontekstual pesisir dapat digunakan..

Kata Kunci: Perangkat pembelajaran, pembelajaran IPA, kontekstual pesisir

 

ABSTRACT

The development of science learning tools assisted by a coastal contextual-based natural science learning media manual. Sumenep Regency is dominated by coastal areas, so that the coastal environment has the potential if it can be used as a contextual science learning medium. The contextual science learning media manual that has been developed previously can be used in the application of contextual learning. The purpose of this research is to produce science learning tools assisted by a coastal contextual-based science instruction manual. The research model used is a 4D development research model which consists of 4 stages, namely: defining, designing, developing, and distributing. This research is limited to define, design, and develop stages. The research results obtained are the feasibility of learning tools assisted by a coastal contextual-based science learning media manual obtained from material expert validation 95.4% and learning expert validation obtaining an average percentage of 94.3% with a very feasible category so that science learning tools are assisted by Coastal contextual-based science learning media manuals can be used

Keywords: Learning devices, science learning, coastal contextual
Dissipative properties of three-layered composite structures. 3. Objects of study
Authors:   Krylov State Research Centre, St. Petersburg, Russia, Yartsev B.A. , Ryabov V.M. ,   St. Petersburg State University, Russia, Parshina L.V. ,   Krylov State Research Centre, St. Petersburg, Russia
Published: May 2022

Object and purpose of research. The object of research is a sandwich plate formed by two rigid anisotropic layers and a soft isotropic layer of viscoelastic polymer in the middle. Each rigid layer is an anisotropic structure formed by a finite number of arbitrary oriented orthotropic viscoelastic layers of composites. The purpose of work is to choose the objects of research demonstrating main features of parameters of natural decaying oscillation of sandwich plates. Materials and methods. Qualitative analysis of differential equations describing decaying oscillations of anisotropic plates of various compositions and reinforcement structures. Main results. The main objects of research are two special reinforcement structures of rigid layers made up of unidirectional CFRP layers: symmetric and asymmetric structures. The symmetric reinforcement structure of rigid layers is formed by an assembly of unidirectional CFRP layers with the same orientation relative to the global axes of these layers. In the asymmetric structures the unidirectional CFRP layers are oriented in the opposite directions with respect to the global axes of the rigid layers. Results of numerical modeling of quasi-homogeneous monocline plate dynamic response are given. It is shown that coupled oscillations of the symmetric sandwich plate are described by two systems of differential equations similar to the equation systems that describe decaying oscillations of quasi-homogeneous monocline plate. While the coupled oscillations of the asymmetric sandwich plate are described by two systems of differential equations coinciding with the systems of differential equations describing decaying oscillations of globally orthotropic sandwich plate. Conclusion. Further to this paper, discussion of numerical experiments on chosen objects of research will be given.
Penguatan Nilai Nilai Pancasila sebagai Fondasi Etika Berkomunikasi pada Pembelajaran Online
Authors: Yuniar Ririt , Bintang Muhamad I.C , Ningrum Diah Fitria , Ritonga Rajab
Published: May 2022

Implementasi nilai-nilai Pancasila yang tampak mulai luntur dalam etika berkomunikasi dan dinamikanya pada proses pembelajaran online maupun bermedia sosial diseluruh wilayah Indonesia perlu menjadi kewaspadaan nasional. Penelitian ini bertujuan untuk menguatkan nilai-nilai Pancasila dalam etika berkomunikasi, sebagai fondasi pendidikan cerdas berkarakter dengan sosialisasi nilai-nilai Pancasila untuk diterapkan dalam proses pembelajaran online agar capaian pembelajaran dapat optimal dan tepat sasaran. Mixedmethod digunakan dalam kajian ini selain analisis kualitatif dan perlu kuesioner yang dipakai untuk mengidentifikasi masalah potensial yang mungkin dialami oleh responden dalam memahami atau menafsirkan pertanyaan, dengan analisis deskriptif kualitatif. Data primer studi dokumentasi literatur penelitian terdahulu dan kuesioner sosialisasi berupa penyuluhan yang dilakukan untuk upaya meningkatkan kewaspadaan terhadap ancaman melunturnya nilai-nilai Pancasila dalam pembelajaran daring perlu diangkat agar membawa dampak positif dalam proses edukasi. Teori Komunikasi dengan model komunikasi transaksional untuk mengupas pentingnya hubungan antara komunikator dengan komunikan saling bertanggung jawab atas efek dan efektivitas komunikasi yang berlangsung. Hasil dari penelitian ini adalah penguatan nilai-nilai Pancasila perlu dilakukan sebagai sebuah upaya kewaspadaan melalui sosialisasi yang secara masif harus terus dilaksanakan secara menyeluruh dan menjadi gerakan nasional.
Evaluation of Achievement of Overburden Production Target Using Fishbone Diagram Method at Pit A Site B PT XYZ, South Sumatera Province
Authors: Ayu Namira Aurah Masyitha , Anas Aryanti Virtanti , Amalia Rizki , Tui Rini Novrianti Sutardjo
Published: May 2022

PT XYZ is one of the companies engaged in the coal mining and energy in South Sumatra Province. Mining activities at the Pit A are still focused on stripping overburden using the Komatsu PC-3000E power shovel digging tool. The company has established a 513,333 BCM production target of overburden stripping in November 2020. While the total overburden production obtained is 488,162 BCM. The existence of factors that affect the productivity of the tool will determine the achievement of production targets, so it is necessary to evaluate production by identifying the factors causing the problem. One of method that can be used to determine the root cause of the problem is by using a fishbone diagram. A Fishbone diagram is a method used to identify the root cause of a quality problem. The purpose of this research is to calculate overburden production in November 2020, identify factors that influence the achievement of overburden production targets using a fishbone diagram, and make recommendations for improvement plans based on factors that affect the achievement of overburden production targets. Based on the results of the fishbone diagram analysis using the 4M pattern consisting recommendations for improvement plans can be designed for each factor causing the problem which is machine, methods, materials, and manpower.
Feasibility Analysis of Runway, Taxiway and Apron Dimensions of Torea Airport in Fakfak Regency, West Papua Province
Authors: Yunus Muhammad , Tuhepaly Ratna Septa Sari , Fitriadhy Ahmad
Published: May 2022

The development of transportation sector modes, especially air transportation modes, is currently experiencing a very significant development. This is because the mode of air transportation in the form of airplanes can make people move very quickly, unlike land and sea transportation modes which require a longer time. In this regard, an airport that meets the requirements in terms of flight security and safety is needed. The aim of the study was to analyze the dimensions of the runway, taxiway, appron and evaluate the feasibility of the runway, taxiway, appron dimensions at Torea Airport in Fakfak Regency, West Papua Province. From the results of the research conducted, it was found that the dimensions of the runway length of Torea Airport have met the minimum requirements set by the International Civil Aviation Organization (ICAO) in 2016 with a runway length of 1201.8 m Torea Airport but in terms of requirements for the type of aircraft ATR 72-600 does not meet the requirements. While for the standard dimensions of the runway width and the width of the runway shoulder of Torea Airport according to the Regulation of the Ministry of Transportation of the Directorate General of Civil Aviation Number: KP 39 of 2015 concerning Technical and Operational Standards of Civil Aviation Safety Regulations
The Impact of Local Wisdom on the Coastal Settlement Spatial Configuration in the City of Parepare
Authors: Baharuddin Hasniar , Asmal Idarwani , Syarif Edward
Published: May 2022

Soreang Settlement is located on the waterfront of Parepare City in South Sulawesi, Indonesia. Initially, it was inhabited by the Soreang kingdom community and then developed due to by local culture. This research was to explain the influence of local culture on the spatial configuration of the Soreang settlement. The research method used is a synchronic reading analysis technique, which is supported by ArcGIS and the space syntax methods. The results of the research are: the first, the spatial configuration of Soreang settlements is influenced by three local cultures, namely sipakatau cultural meaning is sense mutual respect, sipakalebbi cultural meaning is sense of equity and simasemaseang cultural meaning is sense of family. The second, the simasemaseang culture, infact to a clustered settlement pattern formed. Sipakalebbi culture infact to settles into a linear and spreading pattern formed, whereas Sipakatau culture infact to a settles into an elongated and centered pattern formed. Third, Simasemaseang culture forms the most integrated spatial configuration. This research might well be utilized to generate a design for waterfront settlement based on local wisdom.
Free Vibration Characteristics of Thin Spherical Shells
Authors: Sekine Koji
Published: May 2022

Free vibration characteristics of thin spherical shells having freely boundary conditions are analyzed. In this study, the fundamental properties of natural vibration for the spherical shells are investigated. The power function is employed as the admissible function, displacement functions satisfying the geometric boundary conditions are expressed in the form of single series. The eigenvalue problem for free vibration of the shells derived by using the Lagrange’s equation of motion, is processed numerically to acquire the natural frequencies and mode shapes. The reliability and accuracy of the present results are verified by convergence tendencies of the present solutions and comparisons of the data between the current analysis, FEM (finite element method) and published literatures. In numerical results, the variations of natural vibration characteristics of the shells due to the circumferential wavenumber and various shell geometries are illustrated.
Accurate Results for Free Vibration of Doubly Curved Shallow Shells of Rectangular Planform (Part.2 Thickness effect)
Authors: Narita Yoshihiro
Published: May 2022

This paper presents a follow-up study of a previous work that deals with the free vibration of moderately thin isotropic shallow shells under general edge conditions. The same semi-analytical method is used in this study for identical shape and degree of curvature in doubly curved geometry, and accurate natural frequencies are tabulated for a wide range of the shell edge conditions. Emphasis is made, however, to present the frequency parameters for the shallow shells with very thin thickness (representative length/shell thickness=100). In numerical experiments, convergence test is made against series terms in the case of very thin shallow shells. Twenty-one sets of frequency parameters are tabulated for three shell shapes (spherical, cylindrical and hyperbolic paraboloidal shells) and two curvature ratios. These two papers (Part.1 and 2) will constitute the accurate standard in the area of shallow shell vibration of rectangular planform and serve for future comparison and practical design purpose.
Estrategia de Gestión Institucional del Territorio Nacional (EGIT)
Authors: Ospina Gutiérrez Luis Mauricio , Cabrera Ortíz Fabricio , Giraldo Jiménez Walter Adrián , Soto Sánchez José Bertulfo , Olaya Quintero Rafael , Gutiérrez Olano Camilo Mauricio , Pérez Mar David Gorraéz , Rojas Pabón Carlos Humberto , Daza Iguarán Juan Manuel , López Castaño Raúl Fernando , Navas Ramírez Diana Milena , Wihelm Reith Stefan , Roncancio Delgado Nini Johanna , Valencia Pinzón Andrés Rafael , Vélez Aristizábal Julián Fernando , Villamarín Abril Rafael Octavio
Published: May 2022

Desde la creación del Estado, la gestión en el territorio ha sido el principal reto de las instituciones nacionales, regionales y locales. En efecto, siempre se busca la cobertura total de dichas instituciones, reflejadas en una alta gobernabilidad bajo la premisa de lograr altos niveles de seguridad, desarrollo económico y prosperidad social. No obstante, la organización político-administrativa, la geográfica y la estructura socioeconómica del país ha dificultado una fuerte presencia estatal. Por falta de esta, se han constituido espacios vacíos donde confluyen los factores de inestabilidad, creando verdaderos ecosistemas criminales que -en algunos casos- suplantan las autoridades legalmente constituidas, ejercen autoridad y poseen el monopolio económico desde el marco de la ilegalidad. Bajo estas condiciones, el presente documento busca establecer una estrategia de gestión integral del territorio nacional, con el fin de contrarrestar la falta de presencia estatal en diferentes regiones focalizadas y establecer mecanismos de control que aceleran el desarrollo de la estrategia en mención.
A case of ectopic fibroadenoma mimicking left axillary lymphadenopathy
Authors:   VOCATIONAL SCHOOL OF HEALTH SERVICES, ISTANBUL RUMELI UNIVERSITY, DEPARTMENT OF MEDICAL IMAGING TECHNIQUES, ISTANBUL, TURKEY, Sanli Deniz Esin Tekcan
Published: May 2022

Fibroadenomas are the most common benign tumors of the breast. Since they originate from the fibroglandular breast tissue, they cannot be localized anywhere outside the breast. However, they can be localized in accessory or ectopic breast tissue and cause confusion in terms of clinical differential diagnosis. Small ectopic fibroadenomas placed in normal breast tissue are generally asymptomatic and nonpalpable. In contrast, lesions located in the axillary region are usually palpable, due to their superficial location and skin that is thinner at this level. This case report presents the clinical and imaging findings of a patient with a preliminary diagnosis of lymphadenopathy, with a superficial axillary location of the lesion and who underwent biopsy. In our case, no obvious accessory breast tissue was detected by physical examination or ultrasound of the left armpit. Even though there was axillary accessory breast tissue, it was not at a level that could be detected by ultrasound.
Comparative study of open thoracotomy and thoracoscopy on the efficacy of treatment and complications of patients with stage ΙΙ thoracic empyema
Authors:   DEPARTMENT OF THORACIC AND GENERAL SURGERY, GUILAN UNIVERSITY OF MEDICAL SCIENCES, RASHT, IRAN, Aghajanzade Manouchehr , Karimi Babak , Torabi Hossein , Shirini Kasra , Katebi Siavash
Published: May 2022

Background. Thoracic empyema is an inflammatory condition of the pleura that can cause many complications and can even threaten people's lives. So, choosing the right treatment method from all available methods can improve the prognosis, reduce costs and post-treatment complications, thus improving the health of patients after the disease. Video-assisted thoracoscopic surgery (VATS) and open thoracotomy are the most commonly used surgical methods. In this study, these two surgical methods have been investigated, in terms of duration of hospitalization, postoperative pain level and the possibility of air leakage (as postoperative complications). Methodology. Patients with thoracic empyema stage II referred (between 2011 and 2020) to the Poursina and Razi Hospital Medical Center, Rasht, Iran were included in a retrospective cohort study. SPSS software and other statistical tests such as the Shapiro-Wilk test, Mann-Whitney non-parametric test, and Chi-square test were used for statistical analysis, and a P-value of less than 0.05 was considered an acceptable value. Results. The investigation on different qualitative and quantitative factors and complications after surgery showed that patients who underwent a VATS procedure had a shorter hospital stay (5.09±1.67 vs. 7.61±2.03), had a lower pain level (4.81±2.22 vs. 8.24±2.39), and the possibility of air leakage as a postoperative complication (41% vs. 56%) was lower than in the case patients who have undergone open thoracotomy. Conclusions. It can be concluded that choosing the VATS method instead of the open thoracotomy can reduce postoperative complications (such as length of hospital stay, pain level and possibility of air leakage) and can reduce the costs of treatment and the degree of health system use, especially during Covid-19 pandemic.
Los sistemas de transcripción de la lengua hablada
Authors: Hidalgo Navarro Antonio , Sanmartín Sáez Julia
Published: May 2022

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Macrocorpus para el estudio de la norma lingüística culta
Authors: Samper Padilla José Antonio
Published: May 2022

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Corpus oral para el estudio del lenguaje juvenil y del español hablado en Alicante. El corpus ALCOREY y COVJA
Authors: Azorín Fernández Dolores
Published: May 2022

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Predicting Factors of Tuberculosis Preventive Behaviors in Community Among Village Health Volunteers, Udon Thani Province
Authors:   Faculty of Nursing, Mahidol University, Thailand, Wicharit Lerkiat , Nakagasien Piyatida ,   Faculty of Nursing, Mahidol University, Thailand, Krainuwat Kerada ,   School of Nursing Study, Srisavarindhira Thai Red Cross Institute of Nursing, Thailand
Published: May 2022

This study uses a predictive correlational research design. This study aims to analyze the predictability of three common factors: training experience, health literacy, and perception of self-efficacy in tuberculosis (TB) prevention on prevention behaviors in the community of the village health volunteers (VHVs). The samples were obtained from the convenience sampling method. The sample size was determined using the power analysis method and qualified according to the inclusion criteria for a total of 100 people. Data were collected using questionnaires. Data were analyzed using descriptive statistics, Pearson product-moment correlation, and multiple regression analysis. The study revealed that all three factors could predict TB prevention behaviors in the community VHVs in Udon Thani province by 8.8% (R2 = .088, F(3) = 3.070). Only one variable was able to predict TB prevention behavior in the community with statistical significance. Factors of self-efficacy in TB prevention were statistically predictive of TB prevention behavior in the community (β = .244, p < .05). The findings suggest that government officials involved in the development of VHVs’ capacity should encourage VHVs to recognize their potential and competence in TB prevention, as well as develop health literacy on TB prevention, support TB surveillance training policies, prevention, and control.
On the Question of changing the Chinese Language Picture of the World on the example of the functioning of the lexemes jia/ jiating ‘family, home’
Authors: Naumova Ksenia Mikhailovna
Published: May 2022

The subject of the study is the linguistic and cultural changes in the Chinese language picture of the world on the example of the functioning of the key lexemes for the mentality of the Celestial Empire 家 jia/ 家 庭 jiatin ‘family, home'. The material for the work was lexicographic sources of the last 40 years, as well as two constantly updated online buildings (the Chinese Language Building of the University of Leeds and the Balanced Modern Chinese Language Building). The data obtained in the course of the study are systematized and grouped according to the principle of their lexical compatibility with other units. A special contribution of the author to the chosen topic is the presented table of the most frequent collocations. In addition, attempts have been made to describe the semantic field of the concept "jia"/ "family, home", noting modern language trends, as well as to trace the Chinese attitude to family values in retrospect. The novelty of the work consists in a comprehensive linguoculturological approach to the consideration of the lexemes 家 jia/ 家庭 jiatin ‘family, home'. The study showed that, due to the influence of Western liberal democratic values on modern Chinese society over the past thirty years, in particular, on intra-family relations, relations between parents and children, there has been a noticeable shift in the assessment and interpretation of the concept of "family" in the Chinese language. On the one hand, under the influence of the historical events of the XX century, some designations of family groups and clans went out of use, the situation of women and the economic situation in the country as a whole changed, which also led to the emergence of numerous new neologisms fixing these extralinguistic transformations. On the other hand, the older generation and the leadership of the CPC continue to promote the traditional approach to family values, which also illustrates the language material of the corpora.
New communication trends in Serbian and Albanian Media in the Era of the Covid-19 pandemic as an effective means of shaping the Image of Russia in the Balkans 2020-2021.
Authors: Kunic Zvjezdan , Mahmutaj Blerina
Published: May 2022

The goal of this study is to identify new trends in the Serbian and Albanian media during the era of the Covid-19 pandemic, which contributed to the formation of Russia's image in the Balkans. The scientific novelty of the study lies in the fact that for the first time on the material of the popular Serbian and Albanian media in the era of the Covid-19 pandemic, the image of Russia in the Balkans is being studied. As a result, the authors give a generalized description of how the image of the state is formed. This article traces the main realities of relations between Russia and the Balkans. Particular attention is paid to the influence of the West on the formation of communication trends in the media of the Balkan region. The authors seek to trace the process of formation of new trends that emerged in the media of Albania and Serbia in 2020-2021. Also, attention is paid to what new trends have appeared in the Serbian and Albanian media in relation to Russia against the background of the pandemic.
Serpukhovskie Vesti newspaper in the context of the development of Internet technologies (1991-2021)
Authors: Baranova Ekaterina Andreevna , Novoselova Galina Germanovna
Published: May 2022

The regional factor of the development of Russian society is coming to the fore today, as there is a great need for the mediatization of the regional spaces of the Russian Federation. The article addresses the problems of the Russian regional newspaper periodicals, its current state and development trends. The subject of the study is the development of municipal newspapers in the Moscow region. This issue has been studied rather poorly today. At the moment, there is not a single full-fledged study of the printing market of the Moscow region. The object of the study is the formation of one of the newspapers in the south of the Moscow region вЂ“ the Serpukhov News (SV) edition вЂ“ in the era of Internet technologies and media convergence. In the late XX вЂ“ early XXI centuries, many regional newspapers ceased to exist, but the editorial board of Serpukhov News was able to keep the publication thanks to the help of city officials and enterprises. However, we come to the conclusion that the work in the field of digitalization of the publication is going rather badly: "SV" are at one of the first stages of the development of this process. This is largely due to the fact that the newspaper is subordinate to the regional Government and the Main Directorate for Information Policy of the region, is under pressure from the city and regional authorities. The authorities of the Moscow region allowed to engage in the development of the newspaper's website (svesti.ru ), but the Serpukhov editorial office has no resources for this (neither monetary nor personnel). Journalists devote all their efforts to preparing dry materials for a government resource inserpuhov.ru .
Ambivalence as a Carnival Category in Barry Unsworth's Novel "Morality Play"
Authors: Sadovnikova Yuliya Mikhailovna
Published: May 2022

The article examines the main category of carnival - ambivalence based on the material of the novel of Barry Unsworth "Morality Play", which reveals the features of the carnival worldview, a characteristic feature of which is the idea of the dialogical nature of truth. In the novel by the English author Barry Unsworth "Morality Play", the main goal of the carnival is realized, which is to turn inside out the usual ideas about the world as a reasonable hierarchical system, to turn the usual order of things upside down, to ridicule everything familiar and frozen, in order to through denial, ridicule (symbolic death) contribute to the revival and renewal of the world. During the analysis of the character system of the novel by the English author Barry Unsworth "Morality Play", paired images characteristic of carnival thinking were identified: priest Nicholas Barber - confessor of Lord Simon Damian; Margaret Cornwall - a deaf-mute girl; Brendan - Thomas Wells. Scenes and characters paired by contrast and similarity have an impact on the figurative system and poetics of the novel. The findings suggest that the carnival tradition penetrates deeply into the structure of the novel, affecting the plot, forms a comic effect, preserving the uniqueness of ambivalent carnival laughter.
The relationship between language and dictionary
Authors: Янь Xiao
Published: May 2022

The language influences the content of the dictionary. The content of the dictionary reflects the current language situation, and the structure of the dictionary to some extent reflects the structure of the language. Language is a carrier of culture, inheriting its values and at the same time enriching it. It can be said that there can be no culture or history of mankind without language. On the other hand, language, being a reflection of culture, depends on the latter and has to face the limitations that culture puts in front of it in each specific case. A dictionary is a native speaker who records and transmits a language within a certain historical and cultural background. At the same time, the object of dictionary is the language, the type and characteristics of the dictionary largely depend on the language. The subject of this article is the Chinese language and various Chinese dictionaries. The methods of research are induction, analysis. The novelty lies in the fact that this article is the first attempt to analyze the relationship between dictionaries and languages, and in this article many iconic Chinese dictionaries are listed from a historical point of view, and they are analyzed to summarize the relationship between dictionaries and languages. And conclusions are drawn about the existence of relationships between dictionaries and languages that influence each other and contribute to mutual development, and the structure of the dictionary reflects the structure of the language. Clarifying the relationship between languages and dictionaries can also provide a meaningful practical foundation for language learners.
Comparative analysis of the circumstances of time with prepositions of the Russian language and the corresponding expressions of the Chinese language
Authors: Цзинь Лянь
Published: May 2022

The subject of the study is the circumstances of time with the prepositions 'before', 'with', 'after', 'in', 'on', 'for' in Russian, as well as their equivalents in Chinese in terms of their meaning and functioning. The purpose of this work is to conduct a comparative analysis of the minor members of the sentence in the circumstances of time with a preposition in Russian and Chinese languages in order to identify similarities and differences between them in semantics and functioning. To achieve this goal, the use of the following methods was required: descriptive method, continuous sampling method, comparative method, example confirmation method. The scientific novelty of the study consists in a comparative description of the specifics of the use and translation of the circumstances of time with a preposition in Russian and Chinese on the basis of numerous examples taken from the National Corpus of the Russian language and the Corpus of Modern Chinese language. The conducted research of theoretical positions and linguistic material allows us to conclude that the correct expression and translation of circumstantial meanings with prepositions in the Russian language and the corresponding lexical units of the Chinese language (despite some similarity in their semantics) is possible only with the context and knowledge of the rules of word combinations.
Features of the financial and personnel policy of the media of the Moscow region (on the example of the newspaper "Serpukhovskie Vesti")
Authors: Baranova Ekaterina Andreevna , Novoselova Galina Germanovna
Published: May 2022

Many periodicals are today in constant search of means for existence. Even the federal press faces a number of problems that lead to stagnation. Things are even worse in the provinces. The object of the study is the features of the financial and personnel policy of regional media. The authors consider this topic on the example of the oldest newspaper in the south of the Moscow region – Serpukhov News. The authors come to the conclusion that the Government of the Moscow Region and the Main Directorate for Information Policy fully determine both the financial and personnel policies of all municipal newspapers in the region. The media are directly dependent on the decisions of the regional leadership. Anyone who disagrees with this policy is easily dismissed on their own.   Having studied the resolutions of the Government of the Moscow region concerning the activities of the Moscow municipal mass media, as well as analyzing the orders of the Main Directorate for Information Policy of the Moscow region, the authors come to the conclusion that the lack of funding complicates the development of suburban newspapers. A small number of employees have difficulty fulfilling the required volume of publications for the newspaper and its website. The quality of materials suffers greatly. Employees of municipal newspapers, including Serpukhov News, receive a fairly low salary – below the average in the city. This reduces the loyalty of the editorial staff and affects the quality of texts.
Efficacy and safety profile of 2-year netakimab treatment in patients with moderate-to-severe plaque psoriasis in terms of the randomized double-blind placebo-controlled BCD-085-7/PLANETA clinical trial
Authors: Bakulev Andrey I. , Samtsov Alexey V. , Sokolovskiy Evgeny V. , Kokhan Muza M. , Khobeish Marianna M. , Khairutdinov Vladislav R. , Karamova Arfenya E. , Olisova Olga U. , Ignatiev Dmitry V. , Nikiforova Aleksandra N. , Artemeva Antonina V. , Zinkina-Orikhan Arina V.
Published: May 2022

Background. Netakimab, a recombinant humanized monoclonal antibody, specifically binding to IL-17 blocks its activity resulting in plaque psoriasis signs decrease. The results of the first year of BCD-085-7/PLANETA study showed high efficacy and a favorable safety profile in the treatment of patients with moderate-to-severe psoriasis.
Aims. Efficacy and safety assessments of netakimab through 2 years of treatment in patients with moderate-to-severe psoriasis.
Materials and methods. BCD-085-7/PLANETA study is ongoing Randomized, Double-blind, Placebo-Controlled Phase III clinical study. In the study, 213 patients with moderate-to-severe plaque psoriasis were randomly assigned to one of three study groups. In the first two groups of patients, after weekly drug administration, received netakimab at a dose of 120 mg every two or four weeks. In the third group the patients received placebo. During 12-week double-blind study period the efficacy were evaluated based on the proportion of patients achieved PASI 75. After that all patients were switched to netakimab (once in 4 weeks). Patients who failed to achieve PASI 75 at Week 52 were withdrawn from the study. The open period lasts about 3 years. Herein we focus on the results of 2-year netakimab treatment (120 mg, weekly for 3 weeks, then once in 4 weeks), the recommended per label dose. Taking into account the epidemiological situation (COVID-19) and results limitation due to missing visits, additionally to the efficacy analysis in patients received, at least, one dose of netakimab, analysis in those of them who had relevant data on each visit per Protocol was conducted (ITT and PP populations).
Results. At Year 1, PASI 75/90/100 responses were achieved in 88,7/74,5/56,6% patients, respectively (ITT-population) and in 100/85/66% patients, respectively (ITT-population). In 2 year, 69,3/58,0/40,6% sustained their responses in ITT-population and 93,2/78,2/53,1% in PP-population. Through 2 years, the high quality of life sustained among patients. The safety profile remained favorable and immunogenicity was low.
Conclusions. Treatment with netakimab at a dose of 120 mg every 4 weeks results in high rates of sustained clinical response and quality life improvement in patients with moderate-to-severe plaque psoriasis with remains of a favorable safety profile.
Intergenerational Relationship Quality In Terms Of Lifelong Learning: The Effect of Family Climate on The Quality of Intergenerational Relationship
Authors: SARI Tuğba Zişan , CAN Yasin , POLAT Soner
Published: May 2022

Social, emotional and physical relationships are one of the most important tools that human beings need to continue their lives. The people that individuals firstly get in touch with are their families. It is quite possible that individuals who were grown up in the normally multigenerational families are impressed by these families’ atmosphere. Some research findings indicate that individuals constitute their relationship at advancing ages by taking as a reference their first relationship forms. The purpose of this study is to examine the effect of family climate on the quality of intergenerational relationship in terms of different generations. The universe of the study consists of 672 individuals who live in Kocaeli Province in Turkey. The sample group was chosen by convenience sampling method. Study data were gathered by using “Family Climate Scale” which was developed by Björnberg and Nicholson (2007). And adapted into Turkish by Gönül, Işık-Baş, and Şahin-Acar (2018), and “Multidimensional Intergenerational Relationship Quality Scale For Aging Chinese Parents” which was developed by Xue Bai. For data gathering, online questionnaire forms were used. In the analysis of the data, the pearson correlation coefficient was calculated for the correlation between variables. To examine predictive power of the predictor variables on dependent variables simple linear regression analysis was firstly done, and then multiple hierarchical regression analysis was carried out. According to this research findings, relatedness in family, intergenerational authority and cognitive cohesion which are the subdimensions of family climate variable effect and predict of intergenerational relationship quality in a significant way. Thus this study reveals that there is moderate and positive relation between family climate and intergenerational relationship quality. In the light of tese findings, to increase the quality of intergenerational relationships, it is very important to increase interpersonal harmony, similarities in attitudes, beliefs and values and sharing things.
Becker’s nevus and lichen planus: A rare coexistence
Authors: Azeez Femina , Sobhanakumari Kunjumani , Zacharia Meriya , Palakkal Seena , Shaj Kiran
Published: May 2022

Becker’s nevus, an epidermal nevus, may occur alone or may be associated with musculoskeletal anomalies. There are reports of certain inflammatory and neoplastic diseases showing a predilection for Becker’s nevus. We report a patient who manifested lesions of lichen planus. Interestingly, the lesions showed a predilection for a cutaneous area that harbored a Becker’s nevus. We reviewed similar cases where a Becker’s nevus was reported as a site of predilection for other dermatoses and suggest that the possibility of the former acting as an immunocompromised district of Ruocco (an area that shows less resistance to a disease process in comparison to other body areas) may be considered.
SURGERY FOR MEDIASTINAL EMPHYSEMA AND PNEUMOHYDROTHORAX IN COVID-19
Authors:   Grodno State Medical University, Grodno, Belarus, Sushko A. A. , Prokopchik N. I. ,   Grodno State Medical University, Grodno, Belarus, Kul S. A. ,   Grodno University Clinic, Grodno, Belarus, Kropa Yu. S. ,   Grodno University Clinic, Grodno, Belarus
Published: May 2022

The article is devoted to the description of our own observations and treatment of complications of a viral infection caused by SARS-CoV-2. It is noted that spontaneous pneumomediastinum and pneumohydrothorax can lead to worsening of the course of the disease. Special attention is focused on spontaneous intermuscular emphysema of the neck and surgical treatment of SARS-CoV-2 complications according to current literature data. It has been established that isolated subcutaneous and intermuscular emphysema of the neck, which occurs as a complication in patients with viral lung disease in COVID-19, does not require surgical intervention. Spontaneous mediastinal emphysema as a complication of COVID-19 requires emergency cervical mediastinotomy in cases of increasing gas syndrome. In patients with COVID-19 complicated by pneumohydrothorax, early diagnosis of this formidable complication and timely transthoracic drainage of the pleural cavity are important. With the formation of a persistent bronchopleural fistula, active treatment in a low-traumatic way using videothoracoscopy is advisable in those cases where it is clinically possible.
PRO-INFLAMMATORY MARKERS OF EARLY REPRODUCTIVE LOSSES
Authors:   Grodno State Medical University, Grodno, Belarus, Kastsova L. V.
Published: May 2022

The medical and socio-economic significance of the problem of early reproductive losses is determined by a decrease in the birth rate and a deterioration in the demographic situation. Purpose of the study: To evaluate the diagnostic significance of some laboratory parameters characterizing the inflammatory response and their role in early pregnancy losses. Material and methods. Blood serum, medical records, prenatal records of 94 women. The study of interleukin-6 and tumor necrosis factor-alpha was carried out using enzyme immunoassay. The level of white blood cells, banded neutrophils, segmental leukocytes, eosinophils, basophilis, monocytes, lymphocytes and erythrocyte sedimentation rate was determined by general clinical routine methods. Results. Interleukin-6 in combination with segmental leukocytes, monocytes, erythrocyte sedimentation rate can indicate the formation of pro-inflammatory cascade and can trigger abortion mechanisms.
CASE OF ACUTE GANGRENOUS PERFORATIVE APPENDICITIS IN IRREDUCIBLE INGUINAL HERNIA
Authors:   Grodno State Medical University, Grodno, Belarus, Kolotsei V. N. , Strapko V. P. ,   Grodno City Emergency Hospital, Grodno, Belarus, Marmysh G. G. ,   Grodno State Medical University, Grodno, Belarus, Ambrushkevich I. G. ,   Grodno City Emergency Hospital, Grodno, Belarus, Yakimovich D. F. ,   Grodno City Emergency Hospital, Grodno, Belarus, Charyeva O. M. ,   Grodno State Medical University, Grodno, Belarus
Published: May 2022

Acute appendicitis is one of the most frequent abdominal diseases requiring surgical treatment. The variability of its location is characterized by the variability of clinical manifestations, which complicates the diagnosis of the disease. An extremely rare clinical case of acute gangrenous perforated appendicitis in the sac of an oblique inguinal hernia is presented. Surgical treatment was successful: herniolaparotomy, appendectomy, Postempsky hernoplasty were performed.
Current HDAC Inhibitors in Clinical Trials
Authors: Di Bello Elisabetta , Noce Beatrice , Fioravanti Rossella , Mai Antonello
Published: May 2022

Epigenetic modifications in eukaryotic biological pathways can lead to the up- or downregulation of regulatory proteins contributing to disease onset and progression. In the last three decades, histone deacetylases (HDACs) are among the most studied epigenetic targets. In fact, aberrant HDAC expression is associated with numerous types of cancer and neurodegenerative disorders, making HDACs promising molecular targets for the design of new drugs. Many HDAC inhibitors (HDACi) are currently in clinical evaluation for various types of cancer, and some of them reached the market after approval by the Food and Drug Administration (FDA). The present review summarizes the various HDAC classes and relative isoforms. Then we discuss different class or isoform-selective HDACi with a strong emphasis on late-stage preclinical candidates and drugs in clinical studies. Last but not least, we shed light on the pharmacokinetic challenges and future directions in HDACi design.
Organophotocatalytic N–O Bond Cleavage of Weinreb Amides: Mechanism-Guided Evolution of a PET to ConPET Plat-form
Authors: Soika Julia , McLaughlin Calum , Neveselý Tomáš , Daniliuc Constantin , Molloy John , Gilmour Ryan
Published: May 2022

A mild, organophotocatalytic N–O bond cleavage of Weinreb amides is disclosed, thereby expanding the chemistry of this venerable motif beyond acylation. This redox neutral process begins to reconcile the ubiquity of N–O bonds in contemporary synthesis with the disproportionately harsh, stoichiometric conditions that are often required for bond cleavage. The strategy is compatible with the parent alkyl derivatives (N–OMe, N–OAlkyl) thereby complementing tailored O-substituent approaches that require N–OAr groups (Ar = electron deficient). A broad range of acyclic and cyclic derivatives are dis-closed (>40 examples, up to 95%) and the synthetic utility of the method is demonstrated in a range of applications. In the case of cyclic Weinreb amide derivatives, this platform enables ambiphilic amide-aldehydes, of varying chain length, to be generated in a single transformation. Inspired by Emil Fischer´s seminal 1908 synthesis of aminoacetaldehyde using sodium amalgam, this method provides a milder route to access this important class of materials. Mechanistically-guided reaction development demonstrates the involvement of a photoinduced SET mechanism (PET), and this has been further advanced to a consecutive photoinduced electron transfer (ConPET) manifold: this has significantly expanded the scope of compatible substrates.
Aryl Dance Reaction of Arylheteroles
Authors: Nakahara Hikaru , Yamaguchi Junichiro
Published: May 2022

We have discovered a 1,2-migration (aryl dance reaction) of the aryl group on heteroles. AlCl3 can efficiently convert C3-arylheteroles to C2-arylheteroles. Depending on the electron density of the substrate, conversion from C2- to C3-arylheteroles was also possible with catalytic Zn(OTf)2. A one-pot aryl dance/acylation or bromination, and arylation/aryl dance was also demonstrated.
Molecular-Property Prediction with Sparsity
Authors: Adilov Sanjar
Published: May 2022

Machine learning models for molecular-property prediction typically work with molecular representations in the form of fingerprints, descriptors, or graphs. In case of fingerprints and descriptors, molecular representations usually comprise thousands of features, which causes the curse of dimensionality for many tabular models. In this work, we introduce penalized linear models enforcing sparsity on grouped molecular representations. Loosely speaking, sparsity penalties aim to select a relatively small number of features to improve the interpretability and computational convenience of machine learning models.