bluuebunny/crossref_metadata_2025 huggingface dataset:
Health-Related Quality of Life With Carboplatin-Paclitaxel or nab-Paclitaxel With or Without Pembrolizumab in Patients With Metastatic Squamous Non–Small-Cell Lung Cancer
Authors: Mazieres Julien , Kowalski Dariusz , Luft Alexander , Vicente David , Tafreshi Ali , Gümüş Mahmut , Laktionov Konstantin , Hermes Barbara , Cicin Irfan , Rodríguez-Cid Jerónimo , Wilson Jonathan , Kato Terufumi , Ramlau Rodryg , Novello Silvia , Reddy Sreekanth , Kopp Hans-Georg , Piperdi Bilal , Li Xiaodong , Burke Thomas , Paz-Ares Luis
Published: November 2019

PURPOSE

In the phase 3 KEYNOTE-407 study, the addition of pembrolizumab to carboplatin-paclitaxel/nab-paclitaxel significantly improved overall survival, progression-free survival, and objective response rate in patients with previously untreated metastatic squamous non–small-cell lung cancer (NSCLC), with little impact on severe toxicity. We present patient-reported outcomes (PROs) from KEYNOTE-407.

METHODS

Patients were randomly assigned to receive 4 cycles of pembrolizumab 200 mg or placebo once every 3 weeks plus carboplatin plus paclitaxel or nab-paclitaxel, followed by pembrolizumab or placebo for an additional 31 cycles. Health-related quality of life (HRQoL) was evaluated using the European Organisation for Research and Treatment of Cancer Treatment of Cancer Quality of Life Questionnaire-Core 30 (QLQ-C30) and Quality of Life Questionnaire-Lung Cancer Module 13 (QLQ-LC13). Key PRO endpoints were change from baseline to weeks 9 and 18 (during and after platinum therapy) in the QLQ-C30 global health status/quality of life (GHS/QoL) score and time to deterioration in the composite endpoint of cough, chest pain, or dyspnea from the QLQ-C30 and QLQ-LC13. Two-sided, nominal P values are provided.

RESULTS

A total of 554 and 553 patients completed ≥ 1 QLQ-C30 or ≥ 1 QLQ-LC13 assessment, respectively. GHS/QoL score improved for the pembrolizumab-combination group (least squares [LS] mean [95% CI] change from baseline: week 9, 1.8 [−0.9 to 4.4]; week 18, 4.3 [1.7 to 6.9]) and deteriorated in the placebo-combination group (week 9, −1.8 [−4.4 to 0.7]; week 18, −0.57 [−3.3 to 2.2]). Between-group differences were improved for the pembrolizumab-combination group (difference in LS mean scores: week 9, 3.6 [95% CI, 0.3 to 6.9], nominal P = .0337; week 18, 4.9 [1.4 to 8.3], nominal P = .0060). Median time to deterioration in cough, chest pain, or dyspnea was not reached in either group (hazard ratio, 0.79; 95% CI, 0.58 to 1.06]; nominal P = .125).

CONCLUSION

Addition of pembrolizumab to chemotherapy maintained or improved HRQoL measurements relative to baseline and improved HRQoL versus chemotherapy alone at weeks 9 and 18. These results support use of pembrolizumab plus chemotherapy as first-line therapy for metastatic squamous NSCLC.
Use of PCSK9 Inhibitor in a Mexican Boy with Compound Heterozygous Familial Hypercholesterolemia: A Case Report
Authors: Ceballos-Macías José Juan , Madriz-Prado Ramón , Vázquez Cárdenas Norma Alejandra , Aguilar-Salinas Carlos , Tusié-Luna Maria Teresa , Flores-Real Jorge Alberto , Ortega-Gutiérrez Guillermo , Vargas-Sánchez Joel , Lara-Sánchez Carolina , Hernández-Moreno Alfredo
Published: November 2019

We report on the case of an 8-year-old Mexican male, with a 3-year-old clinical diagnosis of familial hypercholesterolemia, and the difficulties encountered in his treatment while in our care. His treatment started with a regimen consisting of ezetimibe/simvastatin, cholestyramine, and a dietary plan of 1600 calories, with a limited intake of 200 mg of cholesterol per day. Problems arose when the patient’s low-density lipoprotein cholesterol (LDL) levels did not meet ideal targets, which prompted the use of LDL cholesterol apheresis (not available in Mexico) for 6 months. As a last resort, PCSK9 inhibitors were administered but the LDL levels remained in the 600 mg/dL range. AmbryGenetics conducted a genetic test employing the Sanger method. The results suggested that there were 2 different mutations for each allele of the same LDL receptor gene (c.249delTinsGG and p.(Cys109Arg)), located in exons 3 and 4, respectively. We identified compound heterozygous mutations in our index case, with him having both the p.C109R mutation (from the maternal lineage), as well as a c.249delTinsGG mutation (from the paternal lineage). The p.C109R mutation has been previously reported, not only in Mexico, but in European regions (Germany, Czech Republic, Ireland, Italy) as well. Functional studies indicated a residual enzymatic activity of 15% to 30% for heterozygotes. To date, the variant c.249delTinsGG has not been reported. This case study illustrates the fact that in Mexico there are limited options available for treatment in such a scenario. As medical professionals, we are limited by the tools at our disposal.
A convenient strategy to clone small RNA and mRNA for high-throughput sequencing
Authors: Li Lichao , Dai Hui , Nguyen An-phong , Gu Weifeng
Published: November 2019

High-throughput sequencing has become a standard tool for analyzing RNA and DNA. This method usually needs a cDNA/DNA library ligated with specific 5′ and 3′ linkers. Unlike mRNA, small RNA often contains modifications including 5′ cap or triphosphate and 2′-O-methyl, requiring additional processing steps before linker additions during cloning processes; due to low expression levels, it is difficult to clone small RNA with a small amount of total RNA. Here we present a new strategy to clone 5′ modified or unmodified small RNA in an all-liquid-based reaction carried out in a single PCR tube with as little as 20 ng total RNA. The 7-h cloning process only needs ∼1 h of labor. Moreover, this method can also clone mRNA, simplifying the need to prepare two cloning systems for small RNA and mRNA; the barcoded PCR primers are also compatible with non-cDNA cloning applications, including the preparation of genomic libraries. Not only is our method more convenient for cloning modified RNA than available methods, but it is also more sensitive, versatile, and cost-effective. Moreover, the all-liquid-based reaction can be performed in an automated manner.
THE RESEARCH OF INTER-PHASE INTERACTION IN SOL-SILICATE PAINTS
Authors: Логанина В.И. , Loganina Valentina , Мажитов Еркебулан , Mazhitov Erkebulan
Published: November 2019

It is proposed to use polysilicate solutions obtained by mixing liquid glass and silicic acid sol as a binder at silicate paints manufacturing. Information is provided on the mechanism for increasing the operational properties of coatings based on silicate paint sol. It has been revealed that the polysilicate solutions form films characterized by higher tensile strength due to the increase of the share of silicic anions’ high-polymer fractions in the structure of polysilicate binder in comparison with liquid glass.

The results of studying the interphase interaction between the pigment and the film-forming agent are presented. It is shown that potassium polysilicate solutions form a smaller contact angle on the surface of the pigment (filler) and are characterized with greater work of wetting and adhesion to the filler (pigment).
ANALYSIS OF THE FIELD TESTS RESULTS OF BORED CONICAL PILES UNDER THE ACTION OF VARIOUS TYPES OF LOADS
Authors: Рыбникова Ирина , Rybnikova Irina , Рыбников Александр , Rybnikov Aleksandr
Published: November 2019

One of the methods of improving the bearing capacity of bored piles is giving them a taper. The feature of these (wedge-type) piles is that under load they work "as a thrust" and transfer part of the load due to the normal component to the inclined side surface. Three sizes of tapered bored piles were tested, with the length of 4.5 m, head diameter 0.4; 0.5; 0.6 m and with cone angle 1o and 2,5o. The test results were compared with the test results of cylindrical piles, 4.5 m long, with head diameter 0.4 m and 0.6 m. It has been discovered that with the increasing cone angle, the bearing capacity of piles against the pressing load, especially the specific load capacity for 1 m3 of material, as compared to cylindrical piles, increases significantly. It has been determined that the larger is the diameter of the head of the pile, the higher is the bearing capacity against the horizontal load, and the bearing capacity against the pullout load is equal to the breakout force of a pile from the soil.
CALCULATION OF THE COMPETITIVE ABILITY CRITERIA OF CEMENT PLANTS
Authors: Вердиян Мэлс , Verdiyan Mels , Богданов В.С. , Bogdanov Vasiliy , Тынников Иван , Tynnikov Ivan , Александрова Елена , Aleksandrova Elena , Герасименко Вера , Gerasimenko Vera
Published: November 2019

The article describes the method of assessing the competitiveness of cement plants, taking into account the quality of products and their energy efficiency. For the first time the criteria of cement production competitiveness and of cement quality have been offered and scientifically grounded, which allowed defining the degree of energy efficiency of each plant. This evaluation of the performance of cement plants is of great scientific and practical importance, as it determines their market attractiveness, reflects the quality of their operation, makes it possible to objectively choose the direction of the existing plants modernization, or of the construction of a new plant. The advantages of wet-method cement production plants not only in ecological, but also on fuel and energy indicators have been demonstrated. The obtained results give grounds to recommend for each plant its energy cost index. The market competitiveness of the produced cement increases with the minimization of this cost index.
Capacity Analysis of Sequential Zone Picking Systems
Authors: van der Gaast Jelmer P. , de Koster René B. M. , Adan Ivo J. B. F. , Resing Jacques A. C.
Published: November 2019

In “Capacity Analysis of Sequential Zone Picking Systems” by van der Gaast, De Koster, Adan, and Resing, a capacity model for sequential zone picking systems is developed. These systems are popular internal transport and order-picking systems in practice. The major disadvantage of such systems is congestion and blocking under heavy use, leading to long order throughput times. To reduce blocking and congestion, most systems use the block-and-recirculate protocol to dynamically manage workload. In their paper, the various elements of the system are modeled as a multiclass block-and-recirculate queueing network with capacity constraints on subnetworks. Because of this blocking protocol, the stationary distribution of the queueing network is highly intractable. The authors propose an approximation method based on jump-over blocking that allows realistically sized systems to be efficiently analyzed and can be used in the design phase of sequential zone picking systems. The results show that the relative error in the system throughput is typically less than 1% compared with simulation.
Litter Quality Affects Termite Sheeting Production and Water Infiltration in the Soil
Authors: Shanbhag Rashmi R , Harit Ajay , Cheik Sougueh , Chaudhary Ekta , Bottinelli Nicolas , Sundararaj R , Jouquet Pascal
Published: November 2019

This study aimed to understand the relationship between termite food preferences and the ecological benefits derived from their activity in terms of soil dynamics and water infiltration. A field study was carried out for six months with different food baits (elephant dung, Acacia leaves, twigs and leaves of Lantana camara as well as Ficus religiosa, Pterocarpus marsupium, Prosopis juliflora, Michelia champaca, Azadirachta indica and Hevea brasiliensis wood stakes) installed on the soil surface in a semi-deciduous forest in southern India. At the end of the experiment we determined bait consumption rates and the amount of soil sheetings covering the different baits. Water infiltration rates were also measured using the Beerkan method. The initial infiltration rates (i.e. average of the first three infiltration rates) under the baits were compared to those at the end of the experiment (average of the last three infiltration rates when the steady state was reached). Three termite species, Odontotermes obesus, O. feae and Microtermes obesi, were found associated with some of the baits in the study area. Among the different baits, elephant dung and Acacia leaves were the most preferred and a relationship was observed between the quantity of soil sheetings and the bait consumption rate. Termite preference for elephant dung and Acacia leaves was also associated with higher water infiltration rates. However, this difference was only significant at the beginning of the experiment and no significant difference was measured once the steady state was reached. In conclusion, we showed that resource quality was of primary importance for soil sheeting production but that the influence of termites on water infiltration remained limited, most likely because of the low stability of their tunnels in the soil.
Patterns of Diversity and Distribution of Arboreal Social Bees’ Beehives within Chimpanzees’ Home Range in a Forest-Savanna Mosaic (Comoé National Park, Côte d’Ivoire)
Authors: Soro Angele Nicodenin , Lapuente Juan , Kone Abduoulaye Ngolo , Yeo Kolo , Konate Souleymane
Published: November 2019

The goal of this study was to explain the patterns of diversity and distribution of arboreal social bees nesting in forest habitats of the Comoé National park, within the home-ranges of wild chimpanzees that consume their honey. Investigations were done using a total sixteen plots, one hectare each, established in three habitat types (mature forest island, secondary forest island and gallery forest). The diversity and distribution of arboreal social bees was estimated with visuals searches. The exploitation of the beehives of these bee by the chimpanzees was also evaluated using chimpanzees’ honey dipping tools as indicators. Results revealed five bees’ species belonging to two tribes; Meliponini (Meliponula ferruginea, Meliponula togoensis, Meliponula bocandei, Hypotrigona gribodoi) and Apini (Apis mellifera). Frequent exploitation of the honey of stingless bees by the chimpanzees was observed, except for H. gribodoi. Meliponula ferruginea was the most exploited species by chimpanzees. A total of 114 beehives were found in the overall established plots leading to an estimated density of 2.4 beehives/ha in the study area. Among the surveyed habitats, mature forest island was found to harbor the highest beehive density (4.2 beehives/ha), followed respectively by secondary-forest island (1.9 beehives/ha) and gallery forest (1.1 beehives/ha). Finally, all bee species were found nesting in cavities of trees with a DBH ranging from 15 to 87.3 cm, with a special preference for Dialium guinneense. However, the DBH of nesting trees and beehives’ height, measured from the ground level, did not significantly influence the honey exploitation by chimpanzees. In sum bee species diversity and distribution might be important in the survival of chimpanzees of a forest savanna landscape.
A Description of Parent Input in IEP Development Through Analysis IEP Documents
Authors: Kurth Jennifer A. , McQueston Jessica A. , Ruppar Andrea L. , Toews Samantha Gross , Johnston Russell , McCabe Katie M.
Published: November 2019

Parent input in individualized education program (IEP) development is the clear expectation in U.S. education law. Every IEP team must include parents, and their input must be equally considered when developing IEPs. The present study used content analysis of 88 IEPs of students with intellectual and developmental disabilities to explore team membership, concerns parents raised during IEP meetings, and evidence that parent concerns and priorities are reflected in IEP goals and supplementary aids and services. Findings reveal that although parents express a range of concerns and priorities, these are translated into goals or services only two thirds of the time. We provide implications of these findings for research and practice.
Case Management Workforce Supporting People With Intellectual and Developmental Disabilities: Indications of a New Frontier of the Workforce Crisis
Authors: Bogenschutz Matthew D. , Dinora Parthenia A. , Johnson Khalilah R.
Published: November 2019

Case management (CM) is one of the most commonly used services by individuals with intellectual and developmental disabilities (IDD), but little is known about the workers who provide CM. This study used a mixed methods approach to gain understanding of the CM workforce in one U.S. state. An online survey was completed by 35 IDD service directors (87.5% of directors in the state); and 113 CMs and CM supervisors participated in semistructured interviews and focus groups. Results indicated an annual crude separation rate of 28.2%, and participants often complained that turnover resulted in caseload sizes that prevented optimal outcomes for people with IDD. A limited applicant pool, duties focused on regulatory compliance, and inadequate wages were cited as major challenges for CMs.
Feedback and Strategies From People With Intellectual Disability Completing a Personalized Online Weight Loss Intervention: A Qualitative Analysis
Authors: Guerra Nichole , Neumeier William H. , Breslin Lauren , Geer Betty , Thirumalai Mohanraj , Ervin David A. , Rimmer James H.
Published: November 2019

Coaching log notes for 15 participants from a 24-week blended online and telehealth randomized controlled trial were analyzed using thematic analysis and analyst triangulation to determine the factors that facilitated participant adherence to weight loss strategies, use of technology, and motivational interviewing. Several participants reported that restricting processed carbohydrates, limiting portion size, and maintaining healthy substitutions were effective nutritional strategies. Participants were less successful with adherence to their exercise goals, often due to time constraints and a lack of support. Results suggested consistent caregiver support improved participants' adherence to weight loss strategies and use of technology. Future programs should address obesity among people with intellectual and developmental disabilities by offering a range of interventions that are customized to their specific weight loss needs.
Macro-conformality of coatings deposited using high-speed spatial plasma-enhanced atomic layer deposition
Authors: Dickey Eric , Niiranen Kalle , Danforth Bryan , Barrow William A.
Published: November 2019

Rotational spatial plasma-enhanced atomic layer deposition has been used to deposit thin films on half-sphere lenses. Non-uniformity of less than

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deposited at 1.4 Å/s and for

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deposited at 6 Å/s.
Impact of high refractive coating material on the nodular-induced electric field enhancement for near infrared multilayer mirrors
Authors: Stolz Christopher J. , Feigenbaum Eyal
Published: November 2019

Electric field enhancement due to nodular defects within quarter-wave optical thickness multilayer mirrors is impacted by the inclusion diameter, inclusion depth, inclusion composition, nodular shape, multilayer angular bandwidth, multilayer coating materials, number of layers, angle of incidence, and polarization. In this modeling study, the electric field enhancement for surface inclusions with diameters up to 2 µm irradiated at 1064 nm at either normal or 45 deg incidence is calculated for high refractive index materials over a refractive index range of 1.7–2.3 for oxide materials commonly used in the near infrared. The thicknesses of the multilayer mirror thin films are determined for each high refractive index material by a requirement to meet a 99.5% reflection. The refractive index was found to have a significant impact on the electric field enhancement, which may offer some insight into the optimal material choice to produce high laser damage threshold mirrors.
The everlasting crisis: Representing the contemporary Athenian cityscape
Authors: Petsini Penelope
Published: November 2019

Crisis recontextualized numerous visual projects, regardless of their authors’ intentions or their initial context of production. Eventually framing our perception of visual production, including the photographic, crisis can now be detected even within pictures and visual narratives which diligently avoid depicting it, or reflect it at a tangent. Expanding on this perception, in this visual essay I will discuss a mode of photographic documentation and interpretation of the Greek crisis in which urban space engages with the recent sociopolitical situation, albeit not always in a straightforward manner. In the first part, I briefly discuss the current context of photography output in Greece, focusing on photographers who made urban space central to their exploration of recent conditions. What many of them share, I argue, is an interest in the commonplace, an aspect of urban landscape which used to be dismissed as insignificant and without interest. I then focus on Nikos Panayotopoulos’s research project Terra Cognita, which I examine as a trailblazing example of this trend. Thoroughly documenting Athens from early 2000 until the end of 2008, namely the period before, during and after the so-called ‘glory days’ of the 2004 Olympics, and portraying a landscape already in decline, this project came to suggest that crisis was here long before we recognized it as such.
Tanulási korláttal küzdő tanulók egyes pszichológiai erőforrásainak vizsgálata
Authors: Virág Krisztina , Dudok Réka , Szabó Éva
Published: November 2019

Kutatásunk célja annak feltárása volt, hogy a tanulási korláttal küzdő és tanulási korláttal nem küzdő diákok pszichológiai erőforrásai különböznek-e egymástól, és ha igen, akkor mely területeken. Nyilvánvaló, hogy a gyengébb tanulmányi eredmények a tanulási korlátokkal küzdő gyerekek esetében összefüggenek képességeik hiányosságaival, eltérő fejlődési ütemükkel, de feltételeztük, hogy léteznek olyan nem specifikus erőforrásbeli különbségek is, amelyek tovább nehezítik a jó iskolai előmenetelt. Úgy véltük, ha sikerül rámutatni ezekre a nem specifikus pszichológiai hiányosságokra, hátrányokra, akkor a tanulási és kognitív képességek fejlesztése mellett ezek erősítése sokat javíthat a tanulási korlátokkal küzdő diákok iskolai teljesítményén. Kérdőíves vizsgálatunkban tanulási korláttal küzdő (N=51) és tipikusan fejlődő diákok (N=51) (korban, nemben illesztett minta) általános énhatékonyságát, általános és tanulmányi felelősségét, valamint proaktív attitűdjét hasonlítottuk össze. A tanulási korláttal küzdő és tipikus fejlődést mutató tanulók eredményeinek összehasonlításából az látszik, hogy a tanulási korlátokkal küzdők alacsonyabb általános énhatékonysággal, valamint magasabb felelősségérzettel rendelkeznek, mint a kontrollcsoportban szereplő diákok. A két csoport proaktivitása nem tért el szignifikánsan.  Eredményeink alapján úgy látjuk, hogy a tanulási korlátok leküzdésének segítésében érdemes nagyobb figyelmet fordítani a pszichológiai erőforrások fejlesztésére, valamint további kutatásokkal feltárni ezek más aspektusait is.
A regionális ökoszisztéma és az egyetemek szerepe az innovációs folyamatban
Authors: Kálmán Anikó
Published: November 2019

Napjaink „okos régiói” képesek hatékony innovációs ökoszisztémát létrehozni a térségi szereplők sokféle – tudás-, emberi, strukturális és kapcsolati - tőkéjét összekapcsolva. Az egyetemek cselekvő közreműködése alapvető fontosságú a regionális erősségek és kapacitások azonosításában és kiaknázásában – összhangban az intelligens szakosodást támogató kutatási és innovációs stratégiák európai programjával. A regionális felsőoktatási intézmények működésében meghatározó jelentőségű a fenntartható fejlődés új generációs koncepciója, ami egyúttal fontos eszköze is „a tudás „körkörös gazdasága” fogalmának megismertetésében és megvalósításában. A koncepció megvalósítását támogatja, hogy a nemzeti és európai finanszírozó szervek újra megvizsgálják és tanulmányozzák a már befejezett projektek eredményeit, segítve a releváns eredmények ismételt felhasználását új regionális és nemzeti kontextusban. Így a kutatási programok és a befejezett projektek eredményei (ötletek, ajánlások, módszerek, gyakorlati javaslatok, prototípusok és találmányok) újra alkalmazhatók a jelenleg futó és a későbbi programokban és projektekben is. Ez erősítheti a vállalkozói egyetemek és az azokkal együttműködő kormányzati szervek együttműködését a társadalmi innováció regionális és európai katalizálásában is. Az Aalto Egyetem és a Párizsi Új Klub által 2010-2014-ben kifejlesztett Aalto Camp for Societal Innovation (ACSI) a társadalmi innováció fontos platformja. Ez a globális hálózatokat egyesítő platform a kutatás, a tanulás és a gyors prototípuskészítés egyidejű elősegítésével hozzájárul a valós társadalmi kihívások kapcsán felmerülő szükségletek innovatív kielégítéséhez és a kapcsolódó rendszerszintű változásokhoz. Az ACSI keretében a különböző karok és egységek közötti együttműködésben az egyetemen belül is alkalmazzák a Tudásháromszög modellt, ami lehetővé teszi módszertani és pedagógiai alapvetéseinek továbbfejlesztését is a gyakorlati alkalmazás tapasztalatainak figyelembe vételével.
Salvaguarda de un patrimonio de la modernidad en Guadalajara: El zoológico de cemento
Authors: Cabrales Barajas Luis Felipe
Published: November 2019

Se aborda la experiencia de salvaguarda del Patrimonio Cultural moderno representado por un grupo de nueve juegos infantiles de cemento construidos en 1967 por el arquitecto Fabián Medina en el Parque Morelos, ubicado en el Centro Histórico de Guadalajara. Como paso previo a dicho análisis se documenta la evolución del área verde, la antigua Alameda originada a mediados del siglo XVIII.El proyecto de construcción de un auditorio al aire libre en dicho espacio representó una amenaza que desencadenó en 2017 un activismo social encaminado a perpetuar el conjunto. El poder público reaccionó positivamente, las esculturas juego fueron conservadas, rehabilitadas y reconocidas como Patrimonio Cultural del Estado de Jalisco. Se trata de una buena práctica que benefició el espacio público y constituye un ejemplo positivo de democracia participativa.
Un viaje a través de la utopía: anarquismo, imaginación geográfica y futuros performativos en la obra de Marie-Louise Berneri
Authors: Ferretti Federico
Published: November 2019

Este articulo aborda los trabajos y archivos de la militante anarquista transnacional Maria Luisa Berneri (1918-1949), autora de un estudio poco conocido pero muy significativo sobre las historias de las utopías y sus espacios. Al ampliar la literatura actual sobre geografías anarquistas, utopismo y sobre la relación entre la geografía y las ‘humanidades’, defiendo que una distinción entre utopías libertarias y utopías autoritarias es esencial para comprender la importancia política del concepto de utopía, que es también un asunto de espacio y de imaginación geográfica. Las críticas de Berneri a la utopía se inspiraron en su anticolonialismo y su antiautoritarismo, centrado especialmente en su original critica de los totalitarismos del siglo XX.  Además, propongo una conexión entre abordajes anarquistas, humanistas, culturales e históricos de la geografía para ampliar el campo empírico y teórico de la disciplina y de sus relaciones con las humanidades. Este articulo contribuye también a las investigaciones recientes sobre el anarquismo transnacional, y afirma que la tradición anarquista no puede ser comprendida fuera de sus redes transnacionales, multilingües y cosmopolitas y de sus practicas concretas. Entonces, solo lecturas contextuales, relacionales y sensibles al espacio pueden dar sentido a esta especificidad anarquista.
Formação de professores de Ciências e Biologia para além da sala de aula
Authors: Sposito Neusa Elisa Carignato , Do Carmo Dias Tamires
Published: November 2019

Este relato de experiência refere-se às atividades de ensino desenvolvidas no projeto intitulado Laboratório de Ensino: Contribuições para a Formação Discente, decorrente do Edital I\19002/2017/PROGRAD/DIREN, da Universidade Federal de Uberlândia. Ele foi desenvolvido no Laboratório de Ensino (LAEN) do Curso de Ciências Biológicas da Faculdade de Ciências Integradas do Pontal (FACIP) sob a responsabilidade da bolsista e da coordenadora, durante um período de dez meses,com 20 horas semanais. Participaram das atividades os licenciandos deste e de outros cursos e professores da Educação Básica. A bolsista aprendeu sobre a gestão do LAEN, realizou as seguintes atividades: a Exposição do Acervo do LAEN que consistiu na apresentação do laboratório e seu acervo; a Oficina Criativa promoveu a interação dos participantes com os materiais do laboratório e a Oficina de Moldes em Gesso de Folhas Vegetais, esta última com metodologia para pessoas com deficiência visual. Constatou-se por meio dos relatos escritos pelos participantes após a realização destas atividades que elas foram exitosas demonstrando que o processo formativo dos alunos pode ocorrer para além da sala de aula.
Nonlinear Controller Design via Inferenced-Augmentation of Equivalent Linearized System
Authors: EseOghene Ovie , D. Chizea F. , M. Akachukwu C.
Published: November 2019

Output compensation of nonlinear system response is studied in this work with an inference-based design method used to control the nonlinear dynamics in the presence of non-linear effects. This design which is driven by practical considerations is informed by the comparisons made between nonlinear models and their linearized derivatives. While a detailed mathematical route has not been followed here, the results seem to show the workability of the proposed method and at its core, the design is driven by its intuitiveness. The proposed technique utilizes as primary parameter for comparison, the steady state error term which is derived from the behavior of the linear dynamics. Possible application areas for this design is in reduced energy control of nonlinear systems. The method was tested in simulation on a generic nonlinear system and a cart-driven inverted pendulum benchmark system.
TRANSFORMASI KAMPUNG PENDRIKAN KIDUL PADA KAWASAN PENDIDIKAN
Authors: Pressilia Adhista Putri , Yuliastuti Nany
Published: November 2019

Kampung Pendrikan Kidul merupakan salah satu kampung lama di pusat kota. Sejak berdirinya Universitas Dian Nuswantoro di Kampung Pendrikan Kidul terjadi perkembangan, baik secara fisik maupun non fisik. Keberadaan universitas yang dengan sendirinya mengundang migrasi dari luar daerah, secara tidak langsung juga menyebabkan gentrifikasi. Hal ini menimbulkan terjadinya perubahan yang membawa peneliti pada pertanyaan penelitian “Bagaimana transformasi sosial, ekonomi, dan fisik suatu kampung lama di pusat kota akibat gentrifikasi pada kawasan pendidikan?”. Penelitian ini menggunakan pendekatan kuantitatif yang bersifat deduktif. Analisis yang digunakan adalah analisis deskriptif komparatif dan skala likert. Transformasi sosial terjadi sebesar 14% yang termasuk dalam minor transformation dan cenderung berubah ke arah negatif. Transformasi ekonomi terjadi sebesar 33% yang termasuk dalam minor transformation dan cenderung berubah ke arah positif. Sama halnya pada fisik lingkungan, terjadi minor transformation sebesar 15% yang cenderung berubah ke arah negatif. Sedangkan pada fisik spasial terjadi minor transformation sebesar 6% yang perubahannya cenderung ke arah positif
PEMAKNAAN PENGHUNI TERHADAP KAMPUNG BUSTAMAN DI KOTA SEMARANG
Authors: Rahmat R. Rafii Bisatya , Widjajanti Retno
Published: November 2019

Kampung Bustaman merupakan salah satu kampung lama yang berada di pusat Kota Semarang. Keberadaan Kampung Bustaman tidak terlepas dari ancaman akibat dari perkembangan kota. Penting bagi masyarakat Kampung Bustaman untuk memaknai tempat tinggalnya. Pemaknaan masyarakat terhadap lingkungan tempat tinggalnya dikenal dengan istilah sense of place. Penelitian ini bertujuan untuk menemukenali sense of place masyarakat Kampung Bustaman di Kota Semarang. Penelitian ini menggunakan teknik analisis deskriptif kuantitatif dengan teknik pengumpulan data kuesioner, observasi lapangan, dan studi literatur. Hasil penelitian menunjukkan bahwa sense of place masyarakat Kampung Bustaman memiliki karakter dan identitas tersendiri yang memberikan ciri khas lingkungan (place identity). Masyarakat juga memiliki keterikatan (place attachment) terhadap Kampung Bustaman karena adanya ikatan secara personal seperti ikatan biografi terhadap Kampung Bustaman dimana masyarakat menganggap Kampung Bustaman bukan sekedar tempat tinggal saja namun juga sebagai tempat yang memiliki arti baginya. Selain itu ketergantungan masyarakat (place dependence) yang tinggi terhadap Kampung Bustaman sebagai tempat yang mampu untuk memenuhi kehidupan sehari-hari.
PENGEMBANGAN WISATA PANTAI MUTUN TERHADAP DAMPAK FISIK, SOSIAL DAN EKONOMI MASYARAKAT DESA SUKAJAYA LEMPASING, KABUPATEN PESAWARAN, LAMPUNG
Authors: Wibowo Tri Adi , Kaskoyo Hari , Damai Abdullah Aman
Published: November 2019

Pariwisata merupakan sektor yang potensial untuk dikembangkan sebagai penggerak ekonomi dan pembangunan bagi masyarakat pesisir. Pantai Mutun merupakan salah satu obyek wisata bahari di Provinsi Lampung yang cukup terkenal dan ramai dikunjungi wisatawan. Desa Sukajaya merupakan desa dengan pemukiman masyarakat yang berjarak tidak jauh dengan kegiatan pariwisata di Pantai Mutun. Penelitian ini bertujuan untuk mengetahui dampak pengembangan objek wisata Pantai Mutun ditinjau dari sektor perundang-undangan dan pengaruhnya terhadap kehidupan fisik, sosial dan ekonomi masyarakat Desa Sukajaya. Hasil penelitian menunjukkan dampak fisik, sosial, budaya, dan ekonomi yang terjadi akibat perkembangan pariwisata Pantai Mutun yaitu perubahan infrastrukur jalan, peralihan profesi masyarakat, hilangnya rasa percaya masyarakat Desa Sukajaya terhadap pemerintah dan pengelola, hilangnya rasa gotong royong antar masyarakat, peningkatan kesadaran pendidikan keluarga dan bertambahnya peluang kerja masyarakat. Pendapatan rata-rata masyarakat Desa Sukajaya per bulan yaitu Rp 815.000,00 dan peluang kerja masyarakat Desa Sukajaya yaitu sebesar 85%.
Interaksi Wilayah di Kawasan Strategis Nasional (Perbatasan) dalam Kerangka Jaringan Perkotaan
Authors: Muazir Syaiful
Published: November 2019

To support the development of lagging areas (border areas), the Government of Indonesia has encouraged urban areas in the border to become strategic areas with certain development priorities. These specified areas could become a growth center for "transferring" the development outputs to the other areas. One of the border regency in West Kalimantan Province is Sambas Regency. There are two categories of "strategic areas" in this regency, that is Sambas District (the regency’s capital city) as a tourism strategic area, and border area (Temajuk and Aruk) as the National Strategic Activities Center. Expectedly, these two strategic areas could interact more balanced and equally in regional development. This research deals with preliminary exploration which aims to identify the tendency of regional interaction in the strategic areas. Interaction is considerably important for the lagging areas in the border to  distribute development outputs from other areas. This study applies the principle approach of network analysis by using different network types such as technical networks (infrastructure), transactional networks, and social networks. The results show that the interaction between developed and lagging areas has not been optimal yet. Sambas District is more attracted to the south closing to the provincial capital city while the border areas more attached to neighboring countries as well as other advanced (internal) areas next to the border.
STUDI SISTEM KOMUNIKASI NIRKABEL UNTUK PENSINYALAN KERETA CEPAT INDONESIA
Authors: Anwar Khoirul , Rangkuti Ikhfan Ammar , Sambas Muhammad Hendra Maulana , Ridwanuddin Abdul Khamid
Published: November 2019

Perkembangan teknologi sistem komunikasi yang sangat cepat juga berdampak kepada perkembangan sistem pensinyalan kereta cepat di seluruh dunia, termasuk Indonesia. Beragamnya sistem pensinyalan kereta cepat dunia sampai saat ini membuat Indonesia harus menentukan dengan cermat teknologi mana yang paling sesuai dengan kondisi alam Indonesia.Pada jurnal ini, kami menyampaikan analisis dan hasil evaluasi performansi teknologi pensinyalan kereta cepat, sehingga membantu berbagai pihak dalam menentukan teknologi terbaik bagi Indonesia. Kami melakukan evaluasi pada tiga teknologi komunikasi nirkabel untuk kereta cepat yaitu global system for mobile communication-railway (GSM-R), terrestrial trunked radio-railway (TETRA), dan long-term evolution-railway (LTE-R) di dunia terkait dengan data teknis, kelebihan, kekurangan, potensi interferensi, dan keandalan teknologi terhadap kecapatan kereta. Beberapa referensi yang kami sadur berasal dari buku railway, paper, jurnal, hasil studi International Telecommunication Union (ITU), International Union of Railways (UIC), dan Asia Pacific Wireless Group (AWG). Seluruh hasil numerik kami dapatkan melalui simulasi komputer.Hasil jurnal ini adalah diharapkan dapat menjadi salah satu referensi dalam pengambilan teknologi yang digunakan pada pengimplementasian layanan kereta cepat di masa kini dan masa depan.
ALAT UJI VISKOSITAS BIODIESEL DARI MINYAK GORENG BEKAS BERBASIS TEKNOLOGI INFRARED
Authors: Muhammad Khairul , Yudhana Anton
Published: November 2019

Alat uji viskositas dalam penelitian ini adalah suatu teknologi infrared untuk menguji tingkat kekentalan minyak biodiesel. Penelitian ini difokuskan untuk menguji biodiesel dari minyak goreng bekas. Telah berhasil dirancang alat uji viskositas dengan memanfaatkan teknologi infrared. Sensor infrared menggunakan LED photodiode dan bagian board microcontroller menggunakan Atmega 328. Sensor infrared berfungsi untuk mendeteksi lewatnya kelereng di dalam tabung yang selanjutya dijadikan rujukan untuk mendapatkan nilai waktu tempuhnya. Metode yang digunakan pada pengujian viskositas ini adalah metode jatuhan kelereng  ke dalam minyak. Kelereng dimasukkan ke dalam tabung yang berisi minyak dan dihitung waktu tempuh  kelereng sampai ke dasar tabung. Tujuan alat ini dirancang untuk mempermudah dalam perhitungan waktu tempuh  yang selama ini dengan cara manual memanfaatkan stopwatch Waktu tempuh yang didapatkan tersebut menjadi dasar untuk penghitungan viskositas minyak. Pengambilan data dilakukan dengan menggunakan tiga sampel biodiesel dari minyak yang berbeda. Ketiga minyak tersebut adalah biodiesel minyak kelapa, biodiesel minyak goreng, dan biodiesel minyak jelantah, dengan jumlah pengujian masing-masing sebanyak 20 kali. Hasil penelitian menunjukkan bahwa nilai viskositas dengan sampel biodiesel minyak kelapa 0,0044398 kg/m.s, sampel biodiesel minyak goreng 0,035651 kg/m.s, dan  biodiesel minyak jelantah 0,05302 kg/m.s. Perbandingan akhir dengan perhitungan secara manual  telah didapatkan didapatkan rata-rata kesalahan relatif sebesar 4,76%.
ANALISIS TEGANGAN DAN ARUS PADA PERANCANGAN ARESTER KASKADE
Authors: Amaral Hanifiyah Darna Fidya , Wijono Wijono , Dachlan Harry Soekotjo
Published: November 2019

Arester merupakan komponen perlindungan tegangan lebih yang dipasang pada sebuah peralatan listrik. Arester dapat digunakan secara individu maupun gabungan dari jenis arester yang berbeda. Penggabungan dua jenis arester yang berbeda dapat dilakukan secara kaskade. Pada makalah ini dilakukan perancangan kaskade arester dengan menggabungkan komponen MOV dan GDT. GDT dirancang pada stage pertama dan MOV pada stage kedua dikarenakan GDT memiliki tegangan kerja lebih tinggi daripada MOV. Kaskade arester dapat berkoordinasi dengan baik apabila arester yang memiliki tegangan kerja lebih tinggi terletak dibagian depan dan tegangan kerja yang lebih rendah diletakkan di bagian belakang. Sehingga GDT dirancang pada stage pertama dan MOV pada stage kedua. Rangkaian kaskade arester berhasil dilakukan dengan dekopling induktor. Simulasi surja juga berhasil dilakukan dengan menggunakan generator impuls. Tegangan surja disimulasikan oleh generator impuls menghasilkan nilai sebesar 920V dengan rise time 1,2µs, berdurasi 50µs. Simulasi arus surja juga berhasil dilakukan dengan menghasilkan arus sebesar 470A dengan rise time 8µs, berdurasi 20µs. Gelombang arus dan tegangan potong pada GDT telah berhasil dilakukan dengan simulasi. Nilai dekopling induktor yang berbeda juga mempengaruhi nilai arus yang mengalir pada MOV sehingga energi yang mengalir pada peralatan listrik yang diproteksi menjadi lebih rendah. Peningkatan nilai dekopling induktor memberikan distribusi energi yang tepat antara arester GDT dan MOV.
Verbstellungsvariation bei Exklamativen aus diachroner Perspektive
Authors: Schallert Oliver
Published: November 2019

Since MHG times, W-exclamatives show variation between verb-second and verb-last word order. Contrary to Näf’s pilot study on Gottfried von Straßburg’s ›Tristan‹ (1992), I demonstrate that verb-last is in fact the more common pattern for W-exclamatives in MHG. This means that a syntactic change must have happened as the language develeped into Modern German, in which verb-second is the predominant order. As for the latter period, the long-standing assumption has been that there are no functional differences between these types. I show that at least for MHG, this null hypothesis is still valid, so that recent suggestions by Repp (2016) about present-day German that gradation is the distinguishing feature, cannot be supported for older stages of German.
Peut-on avoir la vie en puissance ? Sur la cohérence du κοινότατος λόγος de l’âme
Authors: Mittelmann Jorge
Published: November 2019

Aristotle’s broad characterization of the soul has been challenged on account of its reliance on the notion of a “potentially alive body”. J. L. Ackrill famously claimed that no body can meet this description without being alreadyactuallyalive. By a close inspection of both metaphysical and embryological texts, this paper argues that (1) it is embryos (and not fully-formed organic bodies) who provide the right kind of potentially alive subjects and that (2) the schematic character of the soul’s common formula accounts for its seemingly intractable features. It also holds that (3) once the homonymous nature of life is brought into the picture, the κοινότατος λόγος appears unproblematic – at least forsomeof its most troublesome instances.
Aristotle on the Differences in Material Organisation Between Spoken and Written Language: An Inquiry into Part-Whole Relations
Authors: Quarantotto Diana
Published: November 2019

In this paper I aim at showing that, in Aristotle’s view, spoken and written language differ in their material organisation, in particular in their respective part-whole relations. I argue that, according to Aristotle, written language is an additive system (i.e. a system whose parts exist and are produced prior to what they are parts of), whereas spoken language is a non-additive system (i.e. a system whose parts cannot exist and be produced prior to what they are parts of), and that, in his view, spoken language, qua non-additive system, is analogous to organisms. Further, I outline two possible implications of this hypothesis. The first concerns the relevance of Aristotle’s conception of spoken language as a non-additive system to his account of human language’s power to signify. I set out some reasons for thinking that Aristotle endorses the view that the form of human language (i.e. its power to signify) is matter-involving. The second implication concerns the syllable analogy that Aristotle employs in Metaphysics Ζ 17. I argue that the syllable Aristotle refers to is a spoken one, and I develop some consequences of this hypothesis for the meaning of the analogy and, more generally, of the chapter.
Crisippo e l’ἐπελευστικὴ κίνησις: una tappa della polemica anti–accademica?
Authors: Mazzetti Manuel
Published: November 2019

The purpose of this paper is to identify the upholders of the thesis reported by Plutarch, De Stoicorum repugnantiis 23, aimed to reject Stoic determinism. A brief introduction will be devoted to the relationship between this text and the more general context of the Stoic philosophy. Then, I will take into account the objection against Stoic determinism raised by some anonymous philosophers: according to it, causal determinism would be inconsistent with the choice among indistinguishables. Chrysippus replied that if that choice were not determined, it would occur without causes; and this would be absurd. Then I will summarize the most likely hypotheses about the identification of Chrysippus’ opponents, and I will opt for Academics. Finally, I will try to conjecture the link between Plutarch’s passage and the debate among Stoics and Academics about indistinguishables, as we know it from other sources.
Nietzsche, die homerische Frage und die Dialektik der Aufklärung
Authors: Zellini Susanna
Published: November 2019

It seems obvious that Nietzsche has influenced the Dialectic of Enlightenment (1947). The extent to which Adorno and Horkheimer base their argument on Nietzsche, however, remains controversial. By analyzing an early draft of the first excursion of the Dialectic of Enlightenment from 1943, this article demonstrates that Nietzsche was more important for the development of its main concepts than has been assumed, in particular his analysis of myth and enlightenment. In the earlier version of the Ulysses-chapter Nietzsche, together with Rudolf Borchardt, is a pivotal point of reference. Indeed, it is the Nietzschean reflection on Homer and on the pre-Homerian epic—and Borchardt’s interpretation of these themes—that Adorno views as the first original form of the dialectics of enlightenment.
Zur Textentstehung von Nietzsches Gedicht An Hafis. Frage eines Wassertrinkers. Eine editionsphilologische Studie
Authors: Groddeck Wolfram
Published: November 2019

This essay focuses on the genetic text of Nietzsche’s unpublished poem An Hafis. Frage eines Wassertrinkers in order to establish the development of this poem from preliminary versions to an authoritative version. Through such a detailed philological analysis of the text in Nietzsche’s notebooks, it becomes increasingly clear that the final version of An Hafis constitutes an intertextual answer to Goethe’s West-östlicher Divan (1819/1827), which itself was inspired by the late-medieval Persian poet Hafez. Developing from different, and open-ended, semantic configurations to a final version, Nietzsche’s An Hafis also allows us to reassess the editorial practices necessary to shed light on Nietzsche’s unpublished lyrical drafts.
Le kantisme biologique de Nietzsche. L’héritage de Lange à propos de la perception
Authors: Slama Paul
Published: November 2019

In this paper, I show that Nietzsche is a Kantian, and what being Kantian means. He accepts the idea that our perception is configured by concepts which unify and inform the world around us, and which result from a biological evolution of the human species. His Kantianism is thus biological and mainly influenced by Friedrich Albert Lange’s reading of Kant. But this Nietzschean conceptualism must be inscribed in his thought of the will to power, where the perceptive fixation of the world is the result of a degeneration caused by the biological, psychological and historical recovery of the will to power. Thus, I show that Nietzsche’s Kantianism is as biological as it is axiological.