bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of Zr on Microstructure, Mechanical Properties and Corrosion Resistance in Mg-Y-Zr Biodegradable Alloys
Authors: Lupescu Stefan , Munteanu Corneliu , Istrate Bogdan , Earar Kamel
Published: February 2020

The latest magnesium alloys are widely used in the medical field, especially for biodegradable implants. Magnesium alloys are very attractive for applications in different structures in the automotive, aerospace, printing and even medical fields [1]. It should be noted that some magnesium alloys have excellent damping properties as well as good mechanical properties, making them promising to respond to high damping needs for vibration control [1,2]. Although widely used, magnesium has a low corrosion resistance. To improve this resistance, different types of magnesium based on aluminum, such as Ca, Mn, Zn, Zr, Si and rare rare (Y, Gd ..), can be developed. The main purpose of this paper is to investigate the properties of a primary alloy based on the Mg-1Y-0,5Zr system with different concentrations of Zr (0.5,1,2) used in the development of alloys based on the biodegradability of Mg. Surface morphology was characterized by electronic scanning microscopy (SEM), X-ray diffraction (XRD) and optical microscopy. After XRD analysis, it was observed that certain specific compounds were made up of Mg2Ca, MgZr, Mg2Y, Mg24Y5 having the main Mg formed in the hexagonal structure, but Mg24Y5 are the cubic crystalline structure. Also, the microhardness of the alloy is higher than pure Mg and the scratch mark is smaller than that of pure Mg. The corrosion resistance was developed using linear voltammetry in specific medium and corrosion showed that it had significantly decreased for masteralloy. As a final conclusion, the structural properties of this model are recommended for use as medical implants.
Biomaterials Involved in Frontal Area Restorations in Pediatric Dentistry
Authors: Petcu Ana , Savin Carmen , Balan Adriana , Mihalas Eugeniu , Gavrila Laura Maria , Balcos Carina , Antohe Magda Ecaterina
Published: February 2020

Aesthetics in dentistry have truly begun their role in the mid-twentieth century through attempts to perform orthodontic prosthetic restorations in the spirit of dentogenia, thereby making it as natural as possible.The aim of the study is represented by the identification of corellative aspects bethween the incidence of frontal edentation at young patients and the condition for a specific therapy. For the clinical study, 120 young patients were placed under observation, patients which showed up at the Paediatric Dentistry Clinic and private dental practices during the time interval 2016-2018, diagnosed with multiple and various pathologies in frontal area . The patients� age was between 5 and 20+ years, 34.21 % having the age between 15 and 20 years, 60.53 % with age past 20 years, age intervals which, although anchored within the young dentistry framework, present different morphological and functional features, which lay at the foundations of the selection or exclusion of one or the other of the solution therapy solutions of the partial toothless. Regarding the prevention of the therapeutic solutions within the studied group we observe the weight of the temporary solutions for the childhood duration, followed by restorations with composed materials, significant statistical percentages belonging to the fixed restorations with the metal and ceramic crowns, the lowest percentage belonging to the ceramic-type restorations with zirconium or fully ceramic ones, choice dictated by the social and economic criteria, at the patients in which the growth process stagnated, essential elements of the patient�s final behaviour with regard to the body scheme reception. Toothless architecture will lay at the basis of the prosthetic rehabilitation in full accordance with the factorial accumulation, embracing valences of high exigency at the teenager�s age, the frontal toothless being perceived as an amputation, forcing the teenager in isolation. In full accordance to the age and the particular clinical situation with regard to the successful esthetical restoration, the preparation and non-preparation actual techniques for the integrated ceramics constitute a selection option.
The Influence of Diabetes Mellitus in Development and Prognostic of Pancreatic Neoplasia
Authors: Trofin Ana Maria , Zabara Mihai , Cadar Ramona , Palaghia Madalina , Rusu-Andriesi Delia , Ciuntu Bogdan Mihnea , Spiridon Irene Alexandra , Lupascu Cristian
Published: February 2020

Pancreatic cancer is one of the most aggressive malignant diseases due high rate of recurrence and the lack effective medical therapy. Surgery remains the only option for curable treatment but unfortunately, less than 20% of patients are eligibles at the time of diagnosis therefore identifying the risk factors represent a big step for cancer research. Pancreatic cancer is frequently associated with diabetes or glucose intolerance. There are two hypotheses at the base of this observation: either the diabetes cause pancreatic cancer or is a concequences of the cancer. In these theses we studied the patients diagnosticated with pancreatic cancer and with diabetes mellitus type 2. A total of 256 pancreatic cancer cases were identified and 71 patients had diabetes mellitus and 21 patients had glucose intolerance. Mean age 62.2 years, 81% cases were male and in 71% cancer originated form the pancreatic head. In 51.4% cases the diagnosis was in stage IV of the disease. Patients with pancreatic cancer and diabetes mellitus had reduced survival compared with those without diabetes but the difference was not statistically significant. Diabetes mellitus is associated with a decreased survival among patients with pancreatic cancer and reveal a link between chronic glucose intolerance and pancreatic cancer survival. The complex relationship between pancreatic cancer and diabetes requires more clinical research in order to developed new therapeutical posibilities.
Production and Structural Characterization of Some Magnesium Matrix Composites Reinforced with Amorphous/Nanocrystalline NiTi Particulates
Authors: Ciurdas Mariana , Necsulescu Daniela Alina , Pantilimon Cristian Mircea , Ion Vasile , Galatanu Magdalena , Ruiu George , Dumitrescu Ruxandra Elena
Published: February 2020

Two mixtures of elemental nickel and titanium powders in atomic proportions of 50% Ni + 50% Ti and 32% Ni + 68% Ti, respectively, were ground for 40 hours in a high energy planetary mill. In the case of the first mixture, the mechanical alloying was totally produced, while for the second, the alloying was partial. In both mixtures, qualitative X-ray diffraction phase analysis revealed the presence of metastable phases, such as Ni HC and NiTi- R-phase. Also, the equiatomic mixture is characterized by a partially amorphous structure. 10% of each type of mixture submitted to milling was used as reinforcing element in the form of particulates for two magnesium matrix composites. They were obtained by sintering in the plasma at 590�C. In the case of the reinforced with the second mixture composite, the production of new phases other than the matrix and those present in the mixture of nickel and titanium powders after milling were recorded. The electron microscopy images of the two composites have resistant, free of micropores or microcracks matrix / particulates interfaces. The Mg-10% (32 at% Ni + 68 at% Ti) composite is characterized by Vickers hardness higher than that of the composite reinforced with the equiatomic mixture.
Can be Considered the CA-125 and Neutrophil-to-lymphocyte Ratio Values as a Diagnostic Value in Ovarian Endometriosis?
Authors: Dumitru Catalin , Mladin Narcisa Carmen , Craina Marius , Petre Izabella , Moleriu Lavinia Cristina , Bardan Razvan , Bonte Diana Camelia , Ungureanu Emil , Stefaniga Sebastian Aurelian , Susan8 Razvan , Pop Elena , Suciu Nicolae
Published: February 2020

In Romania it is estimated that there are half a million patients with endometriosis. The main symptoms are pain (70% of patients with chronic pelvic pain have endometriosis) and infertility (50% of infertile patients have endometriosis). It is difficult to make an accurate diagnosis. Numerous studies show a 7-10-year delay in diagnosis in women in developing countries. 47% of patients should be seen by more than 5 physicians over time until the diagnosis is established. The treatment for endometriosis is the surgical procedure and it is most often performed laparoscopically. The present study was carried in the Obstetrics and Gynecology Departments of the Pius Brinzeu Emergency Clinical Hospital Timisoara. We have included in this study patients who were hospitalized between 2013 and 2017. We have 142 patients who qualified for this study. All the patients had made the same medical tests: we collected information about their age, the neutrophil, lymphocyte and CA125 values, the position of the cyst and the cyst dimension. The aim of this study is to find if there is any association between the CA-125 markers (coelomic epithelial antigen) and the neutrophil-to-lymphocyte ratio in patients who were diagnosed with ovarian endometriosis by transvaginal ultrasound. In all cases the patients underwent laparoscopic surgery. After performing a correlation and regression analysis we obtained that we have a positive strong significant association between the CA 125 values and the ratio values (r=0.94; R2=0.88; p[0.001) . After the surgical excision of endometriosis, CA-125 can be used to monitor the evolution of endometriosis outbreaks, especially when there is a recurring severe pain.
The Influence of Smoking on Nicotine Exposure Biomarkers and Inflammatory Profile Among Foster Care Teenagers, Romania
Authors: Budin Corina Eugenia , Marginean Corina , Bordea Ioana Roxana , Enache Liviu Sorin , Enache Elena Luminita , Grigorescu Bianca Liana , Biro Levente , Rusu Elena , Nemes Roxana Maria , Todea Doina Adina
Published: February 2020

Foster care young people have an increased overall risk for the development of chronic health conditions.Smoking is a major risk factor for many conditions with inflammatory component. We performed a cross-sectional pilot study to assess the correlation between tobacco consumption status and inflammatory profile among adolescents living with foster parents in the central region of Romania. A number of 35 teenagers aged 10-18 were enrolled. Blood samples were collected by venipuncture for complete blood count (CBC), fibrinogen, Interleukin-6 (IL 6), C reactive protein (CRP). Exhaled CO was measured and urine samples were collected in the same session for cotinine assessment. Of the 123 teenagers initially enrolled, 35 completed the entire study protocol. Urinary cotinine accurately reflected smoker status. Smoking did not affect hemoglobin levels or other hematological parameters in foster care teenagers. The value of C-reactive protein was higher in smokers. Plasma fibrinogen correlated with the daily number of cigarettes. Interleukin-6 did not correlate with the smoker status or the daily number of cigarettes consumed. Our study highlights the existence of an inflammatory response to smoking in foster care adolescents, a social category otherwise predisposed to various addictive behaviors.
Antibiotic-anionic Clay Matrix Used for Drug Controlled Release
Authors: Zegan Georgeta , Carausu Elena Mihaela , Golovcencu Loredana , Botezatu Alina Sodor , Cernei Eduard Radu , Anistoroaei Daniela
Published: February 2020

Anionic clay matrix acting as drug controlled release system have shown in last years a great potential for delivery of bioactive molecules and chemical therapeutics. This organic-inorganic nanohybrid system is high efficient offering an excellent protection of intercalated compounds from degradation. Compared to other nanoparticles used in medical area, anionic clays type layered double hydroxides have found to be biocompatible according to toxicological studies. Ampicillin containing MgAlLDHs and ZnAlLDH samples have been prepared following two routes: anion-exchange procedure and reconstruction from calcined layered double hydroxides. Solid samples have been characterized by FTIR and SEM-EDX highlighting the alteration of pristine LDHs structure when the antibiotic is introduced in the interlayer gallery.
Serum Lipid Profile in Diffuse versus Limited Systemic Sclerosis Data from the SASS cohort
Authors: Ancuta Codrina , Pomirleanu Cristina , Iordache Cristina , Antohe Magda Ecaterina , Chirieac Rodica , Ancuta Eugen , Luchian Diana , Esanu Irina Mihaela
Published: February 2020

Data about lipoprotein changes and their link with cardiovascular disease and atherosclerosis in systemic sclerosis (SSc) are still challenging. We aimed to evaluate serum lipid profile of patients with SSc and to identify potential relation with different disease specific characteristics (clinical, serological, inflammatory tests) in a cross-sectional study. Standard assessments comprised SSc-related parameters (disease subtype, clinical spectrum, immunological tests) and lipid metabolism (total cholesterol and fractions, triglycerides). Impaired lipid profile (low serum HDL- and high LDL-cholesterol, increased serum triglycerides, slightly modification in total cholesterol level) significantly correlated with diffuse SSc, activity (EUSTAR) and severity (MEDSGER), as well as seropositivity for specific antibodies (anti-centromere and anti-topoisomerase 1). The dyslipidemic profile might represent a pathobiological pathway for atherosclerosis in SSc.
The Influence of Food Consistency on the Abutment Teeth in Fixed Prostheses A FEA study
Authors: Tatarciuc Monica , Vitalariu Anca , Luca Odette , Aungurencei Andra , Aungurencei Ovidiu , Fratila Dragos , Popa Diana Diaconu
Published: February 2020

The aim of our study was to evaluate through Finite Elements Analysis (FEA), the stress induced into the abutments and into a metallic bridge by an alimentary bolus of different consistency. Research was carried using the FEA on a model of the bridge with full crowns as retainers in the posterior teeth (34-36), obtained using a contact scanner and computer aided design (CAD) system. We surveyed the stress induced by different food consistency with elasticity modulus between 0 MPa and 60000 MPa. A 6MPa stress was induced by the bridge when the elasticity modulus was equal to 200 MPa. For the maximal value of the elasticity modulus, the stress was 13.68Mpa. The highest values of stresses are registered for the maximal values of the elasticity modulus.
Intratympanic Dexamethasone as First-Line Treatment for Selected Patients With Hearing Loss
Authors: Stefanescu Dragos Cristian , Hainarosie Razvan , Zainea Viorel , Pantea Stoian Anca , Nitipir Cornelia , Marinescu Bogdan Mihai , Corneci Dan
Published: February 2020

There is no consensus among ENT (ear, nose and throat) physicians on the causes, diagnosis and especially therapeutic approach in sensorineural hearing loss (SSHL). The present paper describes our experience with intratympanic dexamethasone injection as initial treatment for selected patients with the sudden sensorineural hearing loss. The results obtained were fully encouraging. The sustained and coherent approaches of the national ENT society through his section of otoneurology, can lead to a diagnostic and therapeutic consensus in the sensorineural hearing loss. Further, the National Health Insurance House must introduce in the methodological norms the therapeutic variants and the concrete conditions for their realisation, in order to have a common medical practice.
Assurance of the Sustainability Reports from the Chemical Industry Practices and trends
Authors: Chersan Ionela Corina , Ignat Gabriela , Ungureanu George , Sandu Ion , Costuleanu Carmen Luiza , Simeanu Cristina , Vintu Catalin Razvan
Published: February 2020

This study was carried out to identify the most recent practices in the audit of the sustainability reports of the companies from the chemical industry, whether they are integrated or not. For this purpose, we analyzed the annual/sustainability reports list available on the GRI website under the name GRI Sustainability Disclosure Database. As the results of the study, we argue that, due to environmental and social hazards associated with chemical industries, a duty to report on Corporate Social Responsibility (CSR) and to audit these reports according to specified standards would need to be introduced.
ZnO Nanoparticles for Antimicrobial Treatment of Leather Surface
Authors: Gaidau Carmen , Ignat Madalina , Iordache Ovidiu , Popescu Laura Madalina , Piticescu Roxana Mioara , Ditu Lia Mara , Ionescu Marcel
Published: February 2020

The paper presents the antimicrobial performances of leather surfaces treated with ZnO nanoparticles as alternative to the use of volatile organic biocide materials. The hydrothermal synthesis of ZnO nanoparticles is described as an efficient and easy to control method compared to sol-gel methods. The characterization of crystallite morphology and size were measured by XRD, the nanopowder particles were assessed by TEM and the dispersion stability in water and in film forming polymers by dynamic light scattering (DLS). The ZnO nanoparticles were uniformly dispersed on leather surface by conventional technologies based on sprayed layers and were available for direct contact with bacteria and fungi. The treated leather surfaces were tested according to adapted diffusion standard methods and proved sensitivity against bacteria and resistance to fungi. The modification of dynamic contact angle of water on leather surface exposed to UV and visible light irradiation confirmed the photocatalytic generation of oxygen reactive species attributed to antimicrobial efficiency.
Comparison of Two Evaluating Methods for Establishing the Marginal Fit on Four Heat - Pressed Resin Inlays
Authors: Baciu Sorana , Berece Cristian , Florea Adrian , Tonea Andrada Voina , Lucaciu Ondine , Burde Alexandru Victor , Rusnac Mara , Manole Marius , Saceleanu Adriana , Mohan Aurel , Earar Kamel , Caraiane Aureliana
Published: February 2020

In this study were compared two investigation methods, a bi- and tri-dimensional techniques by examining the marginal fit pressed in (BioHPP) Inlays. The study pruved that the BioHPP is a high performance polymer which provides very good clinical results.
Autologous Matrix-Induced Chondrogenesis vs Microfracture with PRP for Chondral Lesions of the Knee in a Rabbit Model
Authors: Fodor Pal , Fodor Raluca , Solyom Arpad , Catoi Cornel , Tabaran Flaviu , Lacatus Radu , Trambitas Cristian , Cordos Bogdan , Bataga Tiberiu
Published: February 2020

Currently, microfracturing is the most commonly used cartilage repair procedure in cartilage defects. Our aim was to study the mechanism of in vivo cartilage repair in case of full-thickness articular cartilage damage of the knee using a three-dimensional matrix implanted without any preseeded cells in the defect. We also investigated whether platelet-rich plasma application after microfracture procedure of the knee is associated with improved outcome compared with traditional microfracture treatment alone in a rabbit model. Histological examination of the chondral defects, revealed the largest amount of new tissue with hyaline-like cartilage features in Hyalofast group. At 12 weeks from implantation of the Hyalofast scaffold demonstrated complete filling of the defect with hyaline cartilage in admixture with the scaffold and bone metaplasia in the deepest areas. In the PRP group, complete filling of the defect with an admixture of fibrous and hyaline-like cartilage tissue appeared with a discreet tendency of endochondral ossification. We confirmed the superiority of the autologous matrix-induced chondrogenesis compared to microfracture and PRP or microfracture alone in case of full-thickness articular cartilage damage of the knee.
Comparative Study Using Progesterone and Gynipral - Hexoprenaline Sulphate, with Effects in Postpone Preterm Birth
Authors: Hogea Lavinia Maria , Sas Ioana Tuta , Poroch Vladimir , Nussbaum Laura Alexandra , Sas Ioan , Serban Denis , Erdelean Dragos , Folescu Roxana , Zamfir Carmen Lacramioara , Bredicean Ana Cristina , Simu Mihaela Adriana
Published: February 2020

The prevalence of preterm delivery is rising over time. Preterm delivery is a major cause of mortality in infants. In this study, we aimed to compare the frequency of psychological disorders among women with preterm delivery versus term delivery. In this study, psychological disorders in 25 women, who experienced preterm delivery (gestational age of less than 37 weeks) and in 25 women who had term delivery were examined, using Profile of Affective Distress (PAD) and Symptom Checklist-90 questionnaire (SCL-90). Women, who experienced preterm delivery were treated with progesterone from gestational age 24 and Gynipral - Hexoprenaline Sulphate (C22H30N2O10S), 48 hours before birth. The mean age of the participants was 26.26 for women with term delivery and 28.96 in preterm-delivery. The mean (PAD questionnaire) of the participants in the preterm delivery group being higher than that of the term delivery group, indicating a relevant tendency for the women in the first group to experience a strong affective disorder. The mean score of Symptom checklist-90 questionnaire (SCL-90) in women with term delivery was 49.16 (AS = 12.19) and 92.32 (AS = 29.71) in women with preterm delivery (p [ 0.001). The results reveal statistically significant differences in the short-term emotional reactions between the two groups of participants. Psychological disorders were higher in women with preterm delivery compared to those with term delivery.
Iron Synovitis in Hemochromatosis Associated Arthropathy-A Great Mimicker
Authors: Musetescu Anca Emanuela , Cioroianu Alesandra , Ciurea Paulina Lucia , Florescu Dan Nicolae , Georgescu Claudia Valentina , Florescu Lucian Mihai , Bumbea Ana Maria
Published: February 2020

Secondary hemochromatosis is a condition generated by defects in the iron metabolism such as elevated intestinal iron absorption and increased iron stores in tissues and organs. The current case report presents a 35-year-old female admitted for inflammatory pain of the left ankle, second and third right MCP joints and right sternoclavicular joint associated with Celsian clinical signs, subcutaneous edema and loss of articular function. The patient is known with beta thalassemia major, secondary hemochromatosis and chronic hepatitis C as a consequence of repeated blood transfusions. We pleaded for the existence of a HC-A associated with microcrystalline calcium pyrophosphate dehydrate crystal deposition (CPPD) disease associated with secondary osteoarthritic changes.
The Role of Coagulation Factor VIII Substutution Therapy in the Management of Type A Hemophilia Complications
Authors: Badulescu Oana Viola , Vintila Dan , Ciuntu Bogdan Mihnea , Ciocoiu Manuela , Sirbu Paul Dan
Published: February 2020

Hemophilia is a pathologycharacterized by a disturbance in the normal clotting process of the blood, as a result of a functional deficit of clotting factor VIII or IX.There are two types of hemophilia: type A and type B, the former expressing a deficit of factor VIII, while the latter a deficit of factor IX.C.L., a 43 years old male, was diagnosed at the age of 8 months with a severe form of type A hemophilia. From that time, the patient presentedhemorrhagic episodes, resulting either from trauma or appearing spontaneously and requiring factor VIII substitution therapy and hemostatic treatment.Bloodwork show a prolonged aPTT, as well as microcytic anemia with a low iron serum level, as a result of chronic blood loss.The particularity of this case consists in the high degree of development and recurrence of hemophilia associated complications, leading to superior and inferior limb motor deficits and chronic pain which is currently managed with opioid medication. Also,the patient suffers from chronic hepatitis due to infection with B and C hepatitis viruses as a result of previous lifesaving plasma substitution therapy.Even though the clinical manifestations of hemophilia excert a high cost on the patient�s life as well as the medical system, timely prophylactic factor VIII substitution therapy from the moment of diagnosis until the age of 18 can reduce both the toll on the patient�s health and quality of life and also on the medical costs. Thus, we stress the fact that prophylactic therapy can have a beneficial effect both on patient�s life and also on the health system.
Dioxin Contamination after a Hypothetical Accidental Fire in Baled Municipal Solid Waste Storage
Authors: Rada Elena Cristina , Passamani Giorgia , Ragazzi Marco , Torretta Vincenzo , Istrate Irina Aura , Cioca Gabriela
Published: February 2020

Landfill management usually entails dealing with the production of leachate and the formation of biogas, with the related environmental and public health concerns. One element that tends not to be investigated, is the risk of a fire with the consequent emission of toxic substances, especially dioxins. This study focuses on the case of an existing landfill in which the waste is placed in cylindrical wrapped bales, and where for the purposes of this study, the burning of the waste mass was hypothesized. The Austal2000 model system was used in order to estimate the average air concentrations and the deposition values of PCDD/F.The analysis showed that a landfill may be at risk in terms of fire potential with the consequent release of dioxins. Storage in bales, for various reasons, increases this risk. The analysis of the effects show that the environment and public health would be very seriously compromised. The recovery of the chosen landfill is therefore necessary, especially given the potential dioxin release. The presented analysis wants to be a warning for decision makers who could choose to implement large bale storages without an adequate attention to fire prevention.
Studies Results Regarding Bisphosphonate Therapy in Dental Medicine
Authors: Lazar Adela Cristina , Lacatus Radu , Pacurar Mariana , Campian Radu Septimiu
Published: February 2020

Osteoporosis is a health problem reported worldwide, which predominantly affects women in menopause. Since the percentage level in this population category is quite high, a treatment plan was elaborated to minimize the negative effects of this bone disease, to restore the general state of comfort and allow women to reintegrate in society.
The Impact of Alcohol Consumption on Mortality Among Patients with Complex Cervical Trauma
Authors: Severin Florentina , Cojocaru Elena , Alexa Anisia Iuliana , Bulgaru Iliescu Diana , Cobzeanu Mihail Dan
Published: February 2020

Alcohol seems to be an important risk factor and a major cause of death for the patients with complex cervical trauma. The morbidity and mortality by complex cervical trauma is increasing all over the world, the most common mechanism of damage being a stab wound from violent attack, but also gunshot wounds, road traffic accidents or self-harm are noted. In addition to penetrating trauma, neck injuries can appear due to blunt trauma. We conducted a retrospective analysis on 289 deceased patients by complex cervical trauma. We aimed to focus on the relationship between alcohol blood level and cervical trauma mortality by various mechanisms. In our study, the alcohol blood level in deceased patients by complex cervical trauma is influenced by gender and socioeconomic background. Alcoholism was correlated with autolithic mechanism in 56.3% of the cases and aggression in 46.7%. Complex cervical trauma represents a pathology with multifaceted epidemiological, etiopathogenic and pathophysiological processes. Our results could bring new epidemiological data in order to improve public health policies, and from there to decrease alcohol related mortality on cervical trauma.
Corrosion of an Active Antibacterial Nanostructured Coating on Titanium
Authors: Ionita Daniela , Necula Luiza , Prodana Mariana , Totea Georgeta , Demetrescu Ioana
Published: February 2020

This study aims on antibacterial and corrosion characterization of a complex ceramic coating based on titania (TiO2) nanotubes, hydroxyapatite (HA) and single walled carbon nanotubes (SWCNTs), in physiological environment. Hybrid materials structure was identified by Fourier transformed infrared spectroscopy (FTIR) and their surface analysed by scanning electron microscopy (SEM) and contact angle analysis. The most hydrophilic sample was the one with TiO2-HA coating. The electrochemical behavior of materials has been investigated in Ringer solution performing potentiodiynamic polarization and electrochemical impedance spectroscopy. Antibacterial properties of coatings were determined by contact method using two types of strains, one of them Staphylococus aureus (S. aureus) is a positive gram bacteria and another one Pseudomonas aureoginosa (P. aureoginosa) a negative gram bacteria. The corrosion rates are in the perfect stable domain of corrosion resistance and no breakdown phenomena were observed. A range of stability in tested bioliquid has been established from electrochemical and ICP-MS measurements. TiO2-HA-SWCNTs coating has the best corrosion resistance and the best barrier properties for ions release. Antibacterial effect of TiO2-HA-SWCNTs coating seems to be synergistic being higher compared to TiO2 nanotubes and TiO2-HA coating.
QT Interval Analysis in Patients with Chronic Liver Disease
Authors: Calborean Veronica , Gheorman Victor , Istratoaie Octavian , Mustafa Roxana Edme , Cojocaru Petre Alexandru , Alexandru Dragos Ovidiu , Galceava Oana , Mita Adrian , Miscoci Silvia Alina , Namat Razan Al , Gheonea Dan Ionut
Published: February 2020

The prevalance of QT prolongation in chronic viral liver disease is high and the risk of complications is increased. We wanted to study the QT interval prolongation at the patients diagnosed with chronic hepatic disease and also to evaluate some of clinical and biochemical variables. We studied a cohort with 126 patients diagnosed with chronic viral hepatic diseases hospitalised to Cardiology Department, to the County Hospital of Craiova, between Octomber 2016 and January 2018. We aimed to determine the occurrence of QT interval prolongation in a large series of patients with chronic hepatic disease of viral etiology. We wanted to evaluated the QT prolongation to clinical and biochemical variables. The QT interval was measured by a standard 12-lead ECG for each patient, with prolongation defined as 460 ms. Multiple clinical and biochemical variables were evaluated including sex, age, areas (rural/urban) the frequency of arrhythmic events (PACs, PVCs, Atrial fibrillation, Bradycardia, Tachycardia), NT proBNP, Hb,uric acid, creatinine, alanine aminotransferase (ALT), aspartate aminotransferase (AST) , cholesterol, triglyceride, etc. The group of patients was composed by 43 woman and 83 men. From 43 women, representing 65.06% (461.56 �42.03) and from 83 men, means 66.67% (461.14 � 45.10) presented interval QT prolongation. Studing the distribution of hepatic etiologies we can see that 34 patients had hepatitis B, 35 patients hepatitis C, 5 patients B and C dual virus infection and 52 patients with chronic liver disease of etiology other than viral. We registered close results about QT interval prolongation on group, sex and origine group of patients. The value of QT interval to our patients was higher compared to other values recorder in other studies, at the patients with chronic hepatic disease, despide the fact we chose a higher value of QT prolongation. The highest value of QT interval was in the group of age between 60 and 69, even if in other studies we notice a prolonged QT interval at patients over 70 years old. The biological and biochemical profile of chronic hepatic disease of the subjects included in our study showed no statistical difference between male and female patients.We found a higher incidence of arrhythmic events, at patients with chronic hepatic disease of viral etiology, especially to premature atrial contraction and atrial fibrillation.We found a couple of correlation between QT interval prolongation and the evolution of chronic hepatic disease of viral etiology. It is very important to develop a strong and complex strategies to prevent and to treat the arrhythmic event presented at the patients diagnosticated with hepatic disease, because of the higher risk of developing life-threatening arrhythmias, includen sudden cardiac death.
Collagen - Lidocaine Microcapsules with Controlled Release for Tooth Extraction Pain
Authors: Marin Maria Minodora , Ignat Madalina , Ghica Mihaela Violeta , Albu Kaya Madalina , Dinu Pirvu Cristina , Anuta Valentina , Popa Lacramioara
Published: February 2020

The pain management is therefore of paramount importance and the local anesthetic treatment has to be considered. Thus, the purpose of this study was to design and characterize some collagen microcapsules incorporating an anesthetic. The collagen hydrolysate was prepared by spray-drying forming micro sizes spheres (microcapsules) which were loaded with 1% lidocaine (anesthetic) and cross-linked with different cross-linking agent: tannic acid, glutaraldehyde and genipin, in order to obtain solution for tooth pain. The wetting behavior of dried microcapsules powders was determined by contact angle measurement. The microcapsule solutions were characterized by dynamic light scattering (DLS) and in vitro release of lidocaine was investigated. These therapeutically products, based on collagen microcapsules, a local anesthetic and three cross-linking agents, could have potential biomedical application in tooth pain healing treatment.
Focus on the Asbestos-Related Diseases in a Pulmonology Department
Authors: Arghir Oana Cristina , Dantes Elena , Borgazi Erdin , Rascu Agripina , Socaci Adriana
Published: February 2020

Romania implemented the complete asbestos ban legislation in 2004. Like in other countries, it would be expected that asbestos-related diseases (ARD) to reaching their peak in the following years. In this study, we present the characteristics of ARD among patients admitted in the Clinical Pneumophthisiology Hospital of Constanta, Romania, during 3 years: 2015 - 2017). Previous industrial asbestos exposure in Medgidia, a town situated in Constana County, was one of the highest in Romania, but the number of ARD cases remained relatively small. This situation demands a better investigation and surveillance of all previously exposed employees based on a comprehensive occupational history and a better collaboration with the occupational health specialists.
Fresh Ulva Lactuca Alcoholic Fermentation Products and yields
Authors: Cioroiu Doinita Roxana , Koncsag Claudia Irina , Gudovan Dragos , Dobre Tanase
Published: February 2020

The optimization of the ethanol yield obtained by alcoholic fermentation of fresh Ulva lactuca in the presence of cellulase and Saccharomyces cerevisiae yeast was performed. Three main factors affecting the process were considered: the solid-to-liquid ratio (S), cellulase-to-algal biomass ratio (R), expressed as cellulase units (U) per gram of dry matter (DM), and the alcoholic fermentation temperature (t). The optimal parameters were: S=1/24 g/g, R=16 U/ g DM and t=35�C, when alcohol yield was 0.34 g/100 g fresh alga, within the range of other authors� experimental data. Over 200 compounds were identified in the distillate from the fermentation broth, recommending Ulva lactuca as a sustainable source of drugs, intermediates for biosyntheses and biomaterials. The yield of these compounds was 5.92 g/100 g fresh alga, in the same conditions. The yields of ethanol (0.013-0.023 g/g DM) and volatile compounds (0.199-0.398 g/g DM) were predicted depending on the process factors using regression equations obtained by ANOVA analysis of experimental data.
Synthetic Mesh for Large Ventral Hernia Repair Correlated with Evaluation of Quality-of-life A 5 years retrospective study
Authors: Noditi George , Zoler Raul , Noditi Gheorghe , Fulger Lazar
Published: February 2020

Ventral hernia mesh repair is considered a standard procedure in most countries and widely accepted as superior to primary suture repair. We conducted a 5 years retrospective observational study on large and giant incizional hernia repair in our Clinics. 176 consecutive patients who had a ventral hernia repair with mesh implant in 2012-2016 were evaluated in terms of demographic characteristics, comorbidities, surgical conditions (defect size, mesh type, positioning of the mesh, length of hospital) and surgical outcomes by means of EuraHS-QoL score pre- and 30 days postoperative to assess quality of life (Qol). Alloplastic substitution with polypropylene, polyester and Dacron mesh has been used in all cases. Polypropylene mesh has been used in most of cases (91%). Most preferred mesh position was intraperitoneal (78%), then retromuscular (15%) and preperitoneal (7%). Immediate postoperative complications appeared in 41 cases (23.3%). Mean hospital length was 14,3 days. We could notice a double pre- and postoperative difference for the pain, with statistical significance (2.71�1.70; p=0.23) and the same pattern of distribution for restriction of activities and for cosmetic discomfort.
The Relationship of Metabolic and Endocrine Parameters with Associated Diseases in Diabetes Mellitus
Authors: Tilinca Mariana Cornelia , Pal Sandor , Preg Zoltan , Barabas Hajdu Eniko , Tilinca Raluca , Sallo Marta German , Nagy Eniko Nemes
Published: February 2020

The most common comorbidities in patients with diabetes mellitus are cardiovascular diseases, obesity, dyslipidemia, thyroid disorders but other associated diseases may frequently occur. Laboratory tests are useful investigation methods that may reveal the subclinical manifestations of the disease but they are also essential for patient monitoring. The aim of the study was to assess laboratory parameters and associated diseases in diabetic subjects and to implement a scoring system with a predictive role in the evolution of the cases. Material and methods: The study group consisted of 195 subjects with documented type 1 or type 2 diabetes. About half of the cases were collected from the Procardia outpatient unit, and the rest were patients admitted to the Diabetology Clinic in T�rgu Mure�. The study was performed between January - June 2017. The results of the laboratory tests, as well as the information regarding comorbidities and treatment, was collected and patients� body mass index was calculated. Based on the clinical data, a scoring system, called Diabetes Complication Severity Index (DCSI) with a predictive role, was implemented. The diabetic outpatients presented significantly better carbohydrate metabolic balance compared to the hospitalized subjects. No significant differences could be observed regarding kidney function, hepatic status and lipid profile of the two subgroups of diabetic subjects. The most important comorbidity observed in both patient groups was arterial hypertension. The hospitalized diabetic subjects had significantly higher incidence of ischemic heart disease and significantly lower incidence of thyroid disorders compared to the outpatients. The DCSI scoring system revealed that comorbidities are more frequently present in the hospitalized patients compared to the ambulant diabetic subjects. Evaluation of clinical status and laboratory results in diabetic patients followed by implementation of a scoring system based on the data obtained regarding comorbidities could help clinicians to set up an individual treatment plan for these patients, focusing on preventing other complications.
Kinetic Studies of Zn(II) Removal from Single and Binary Solutions by Synthetic Hydroxyapatite - Based Nanopowders
Authors: Busuioc Laurentiu Teodor , Simonescu Claudia Maria , Nechifor Gheorghe , Radoi Elena , Girbea Ionut Eduard
Published: February 2020

A kinetic study has been carried out with two hydroxyapatite nanopowders to establish the mechanism involved in heavy metals removal from aqueous synthetic solutions. The samples of nanohydroxyapatite have been previously characterized. The first sample represents a pure hydroxyapatite (HAP) nanopowder named HAP-1, and the second sample (HAP-2) consist of a mixture of hydroxyapatite (HAP; Ca10(PO4)6(OH)2) and b-tricalcium phosphate (b-TCP; Ca3(PO4)2). Batch experiments with single and binary Zn(II) and Pb(II) aqueous solutions have been performed. According to this research study, it was found that the both nanohydroxyapatite samples show good heavy metals adsorption capacity, and selectivity for Pb(II) ions. A more pronounced decreasing of sorption capacity of Zn(II) ions from binary solutions compared to that registered from single heavy metal ion solutions has been observed. From the kinetic point of view, the sorption process can be described for both heavy metals as a pseudo-second-order kinetic process. According to this model, the Zn(II) and Pb(II) sorption can be achieved by chemical reactions between heavy metals and functional groups of adsorbents. The obtained results are indicative of good hydroxyapatite adsorption ability towards Pb(II) and Zn(II) ions.
The Consequences of Excessive Chemicalization on Fruits Quality
Authors: Gitea Manuel Alexandru , Bungau Simona , Gitea Daniela , Purza Lavinia , Nemeth Sebastian , Samuel Alina Dora , Badea Gabriela , Tit Delia Mirela
Published: February 2020

Chemistry in agriculture has been considered for several decades a formula synonymous with progress and development, as chemical engineering, mechanization, irrigation, modern agro-technical processes have contributed to a substantial increase in production. At present, the use of pesticides to increase agricultural productivity is considered to be a global hazard to the environment. This study examines changes in tree tolerance for major diseases and pests, disease and pest behavior, and the changes that occur in the recommended pesticide treatment. The researches were carried out on different species of fruit trees (apple, plum, and almond), cultivated in an intensive system, in five orchards located in Bihor county. The behavior of each species, as well as the behavior of different varieties with respect to tolerance to major diseases and pests, have been observed over the last 5 years (2013-2017). In addition, pesticide residues were monitored from all crops of apple, plum and almond. During 2015-2017, from March to May, the diseases were more virulent, requiring intensive intervention with systemic and contact fungicide combinations to achieve optimal efficiency; this fact has been correlated with the increase in the number of samples containing pesticide residues. This perspective allows an ecological remodeling of current progress in orchard development, including all aspects of environmental protection and the impact on population2 s health.
Sorption of Bisphenol A (BPA) in Aqueous Solutions on Fullerene C60
Authors: Senin Raluca Madalina , Ion Ion , Oprea Ovidiu , Vasile Bogdan , Stoica Rusandica , Ganea Rodica , Ion Alina Catrinel
Published: February 2020

The important applications of engineered carbon nanomaterials in the last years represent the cause of their presence in the aquatic environment. The properties and on the composition of the aqueous solutions, will influence the distribution and the availability of fullerene (nC60) as a sorbent, in different aqueous environmental media. In this study, the adsorption of bisphenol A (BPA) from aqueous solutions on fullerene C60 was investigated in batch experiments. The kinetic, the isotherm and the thermodynamic of the reactions were determined. According to the Langmuir model, the maximum sorption capacity of BPA by the fullerene C60 in the studied systems was of 74.44 mg/g, at 20 0C, being observed that it varies by the temperature. The kinetic data were better described by the intra-particle diffusion model in the optimum range of pH values between 7 and 9.
Hyperkalemia and Cardiovascular Diseases: New Molecules for the Treatment
Authors: Diaconu Camelia Cristina , Stanescu Ana Maria Alexandra , Stoian Anca Pantea , Tincu Radu Ciprian , Cobilinschi Cristian , Dragomirescu Razvan Ion Florin , Socea Bogdan , Spinu Dan Arsenie , Marcu Dragos , Socea Laura Ileana , Bratu Ovidiu Gabriel
Published: February 2020

Potassium is a key electrolyte for the maintenance of cardiovascular system health, being involved in a broad array of vital physiological processes. Hyperkalemia is a common clinical problem and potentially life-threatening condition predominantly seen in patients with cardiac and kidney disease, especially if receiving treatment with inhibitors of the renin-angiotensin-aldosterone axis. Several studies have demonstrated the short and long-term morbidity and mortality that hyperkalemia induces in patients with cardiovascular diseases. Plenty of data is currently emerging on this topic. This paper aims to review the new strategies and molecules for improving the management of hyperkalemia.
Circulating Chemerin Levels, Anthropometric Indices and Metabolic Profile in Morbid Obesity
Authors: Aursulesei Viviana , Timofte Daniel , Mititelu Tarau Liliana , Mocanu Veronica , Namat Razan Al , Aursulesei Victor Cristian , Costache Irina Iuliana
Published: February 2020

Recent data suggest that chemerin could be important for the pathophysiology of obesity. However, its relation with clinical indices of obesity and metabolic parameters is controversial and less studied in metabolic healthy patients with morbid obesity. Our study demonstrated that circulating chemerin is related to anthropometric indices, it is an independent predictor for waist to hip circumference ratio as well as for decreased insulin sensitivity, but not for other metabolic changes. Chemerin/adiponectin ratio is also a useful parameter, but not superior to chemerin levels.