bluuebunny/crossref_metadata_2025 huggingface dataset:
Una aproximación a la forma de enseñar las Ciencias Sociales en la experiencia escolanovista de Olga y Leticia Cossettini, Rosario, 1935-1943
Authors: Mosso Agustina
Published: August 2017

El presente artículo aborda un tema visitado por la historia de la educación, la propuesta pedagógica de las hermanas Cossettini, y ocasionalmente puntualizando en la mayor, Olga, por ser la directora de la escuela en la cual llevan adelante la experiencia, enmarcada en las pedagogías adheridas a la corriente de Escuela Nueva. A pesar de que la profusión de investigaciones alumbra cuestiones, va dejando otras en las sombras. Es por eso que, en este artículo, nos detenemos en un punto específico del trabajo de estas maestras: la enseñanza de las ciencias sociales. Al respecto nos preguntamos cómo fue presentado el contenido de estas ciencias en la propuesta pedagógica experimental de la escuela Carrasco (entre 1935-1943). Y a los efectos de responder a dicho interrogante, tomamos como fuentes el Plan Asociado para las Ciencias Sociales y lo triangulamos con diarios de maestras, cuadernos de los alumnos, entre otros documentos más, con el fin de captar su puesta en la práctica específica.
Valoraciones y prejuicios sobre La asombrosa excursión de Zamba
Authors: Gomes Gabriela
Published: August 2017

Este artículo analiza la serie animada infantil La asombrosa excursión de Zamba, a partir de sus diálogos e imágenes. Nuestra hipótesis es que dicha serie infantil permitió “profanar” a la historia académica, permitiendo un nuevo uso y acercarla al público infantil. Siguiendo los términos de Friedrich Nietzsche, consideramos que la serie transita por una doble senda entre la historia monumental y la anticuaria, ya que ofrece una visión de la Historia muy ligada al valor de los "grandes héroes nacionales" a la vez que reproduce ciertos mitos de la historia argentina.
Intervalos de referencia de minerales en cerdos confinados de diferentes genéticas y categorías
Authors: LUNA Mónica L. , ROLDÁN Viviana P. , CAMPA Mauricio , MANNI Diego , BELLEZZE Julio , AGOSTO Mariano
Published: August 2017

En Argentina, no existen datos regionales de intervalos de referencia de minerales en cerdos según las líneas genéticas actuales y distintas categorías de producción en sistema intensivo. Por ello, el objetivo del presente estudio fue determinar intervalos de minerales: calcio, fósforo, magnesio, sodio, potasio, hierro, cobre y cinc, en suero de cerdos en establecimientos del centro de Santa Fe y de Entre Ríos. Se trabajó con 300 muestras de sangre de cerdos sanos de dos líneas genéticas diferentes en las categorías de lechones recién nacidos, lechones destetados, hembras nulíparas gestantes seleccionadas fenotípicamente para la reposición del plantel, y hembras multíparas gestantes. Se determinaron las concentraciones séricas de los minerales por espectrofotometría de absorción atómica (FAAS) con un equipo Perkin Elmer modelo Analys 200, con métodos oficiales de AOAC. Se analizaron también muestras de agua. Los intervalos de referencia se calcularon utilizando parámetros paramétricos o no paramétricos dependiendo de la distribución de los datos. Los valores medios, medianas, valores mínimo y máximo e intervalos de referencia, para los distintos minerales en cada categoría productiva, se presentan en tablas. Los intervalos de referencia calculados serán útiles para el diagnóstico de deficiencias mineral y la vigilancia nutricional en cerdo de producción de carne.
Tense, aspect and narrative structure in oral narratives of students and native speakers of French: A comparative study
Authors: Mavaşoğlu Mustafa
Published: August 2017

This study aims to comparatively examine features of tense, aspect and narrative structure in oral narratives of Turkish L1 learners of French as a foreign language and native speakers of French. The sample of the study included 93 students enrolling in first, second, third and fourth years of French Language Teaching Department at Çukurova University as well as 16 native speakers of French. Participants were first asked to watch French dubbed versions of Lion King and A Christmas Carol, both Walt Disney productions, then to orally retell these movies. Data were analyzed in terms of the aspect and discourse hypotheses. Results indicated that both students and native speakers of French highly structured their oral narratives by prÃ©sent. Oral narratives with high use of prÃ©sent indicate that students began to dispose of the effects of both narrative structure and inherent semantic properties of verbs. However, students did not have same levels of getting rid of the effects of narrative structure and lexical aspect. Namely, junior and senior students found to be more influenced by narrative structure and lexical aspect compared with freshman and sophomore ones.
NUVEM DE PALAVRAS E MAPA CONCEITUAL: ESTRATÉGIAS E RECURSOS TECNOLÓGICOS NA PRÁTICA PEDAGÓGICA
Authors: Prais Jacqueline Lidiane de Souza , Rosa Vanderley Flor da
Published: August 2017

Este trabalho discute a utilização da nuvem de palavras e do mapa conceitual como estratégias pedagógicas a partir do uso de recursos tecnológicos como o Wordle® e CmapTools®. A aplicação dessas ferramentas tecnológicas ocorreu em um curso de extensão visando à formação de professores para a inclusão e, portanto, foram empregadas para ensinar e para avaliar a apropriação do conteúdo desse processo formativo: a inclusão educacional.  A questão principal de investigação é: de que forma licenciandas em Pedagogia percebem a utilização da nuvem de palavras e do mapa conceitual como atividades didáticas? Para isso, foi utilizada a pesquisa do tipo intervenção pedagógica, a coleta de dados feita por meio de questionários, diário de campo e atividades desenvolvidas, sendo os dados interpretados pela análise de conteúdo. Os resultados indicaram que as atividades didáticas promoveram a familiaridade com o uso de TIC no processo de ensino e de aprendizagem, e que contribuíram para a sistematização e a apropriação do conteúdo do curso de extensão como uma ação didática formativa.
Amino acid diversity on the basis of cytochrome b gene in Kacang and Ettawa Grade goats
Authors: Lestari D. A. , Sutopo S. , Kurnianto E.
Published: August 2017

The objectives of study were to identify and assess the amino acid diversity of Cytochrome b (Cyt b) gene, genetic marker and characteristic of specific amino acid in Kacang and Ettawa Grade goat. Nineteen heads of Kacang goat (KG) and twelve heads of Ettawa Grade goat (EG) were purposively sampled. The genomic DNA was isolated by Genomic DNA Mini Kit (Geneaid) and amplified Cyt b using PCR method with CytbCapF and CytbCapR primers and was sequenced. The results showed that there were two specific amino acids that distinguish KG and EG goat with C. hircus and C. aegagrus and four specific amino acids that distinguish KG and EG goat with C. falconeri, but there were no specific amino acids can be used as a genetic marker to distinguish between Kacang and EG goat. In conclusion, specific amino acids in Cyt b gene can be used as a genetic marker among KG and EG goat with 3 goat others comparator.
Comparative performance of Landrace, Yorkshire and Duroc breeds of swine
Authors: Zebua C. K. N. , Muladno M. , Siagian P. H.
Published: August 2017

The objectives of this study was to analyze the comparative ability of animal genetic, using evaluation of production that has important economic traits including Landrace, Yorkshire, and Duroc breeds of swine. A total of 49 swine consist 15 boars and 34 gilts, with average body weight of 18.50-21.50kg were used in this research. All of samples were raised in the same pen and feeding management. This research used the experimental method of Completely Randomized Design involving three treatments of animal breeds including Landrace, Yorkshire, and Duroc breeds. The data were analyzed by using analysis of covariance procedur General Linier Model and Least Square Means test. Boars and gilts were analyzed in separated data. The result showed that the effect of breed was significantly associated for all traits, but not for boars feed intake. The overall, Yorkshire and Landrace performed better than Duroc for average daily gain, feed conversion ratio, selection index, and age at 90 kg body weight. However, Duroc boars and gilts had the thinnest backfat followed by Yorkshire and Landrace.
Effect of sunflower oil supplementation as unsaturated fatty acid source on rumen fermentability and performance of lactating Garut ewes
Authors: Khotijah L. , Pandiangan E. I. , Astuti D. A. , Wiryawan K. G.
Published: August 2017

The study was aimed to evaluate the increasing levels of ration energy, with fat-rich unsaturated fatty acids from sunflower oil on the nutrient intake, rumen fermentability and performance of ewes. The experiment used fifteen ewes of 1.5 years old, primiparous, caged individually with their lambs and conducted three treatments and five replications from a completely randomized designed. Those treatments included R1= ration with 0% sunflower oil addition, R2= ration with 4%sunflower oil addition, R3= ration with 6% sunflower oil addition. The variables consisted of dry matter intake, nutrients, ewes performances (birth weight, weaning weight, decreased of body weight), total and partial VFA, the ratio of acetate: propionate, methane production, protozoa and bacterial population. Data were analyzed statistically and descriptively. The results showed that the treatments did not influence dry matter intake and nutrients,. rumen fermentability and ewes performances. Although the treatments increased (P<0.01) fatconsumption and reduced shrinkage of body weight. It can be concluded that the adding sunflower oil as the resource of unsaturated fatty acids up to 6% of the ration was not negatively affected the fermentability of rumen, moreover can improve ewes body condition and, accelerated body weight recovery
Effect of High Temperature Intermittent Drying on Rice Seed Viability and Vigor
Authors: Wang Pan , Li Dong , Wang Li-jun , Adhikari Benu
Published: August 2017

This work aimed at determining whether high temperature intermittent drying followed by tempering at ambient temperature could preserve the seed viability and vigor. Japonica and Indica rice seeds with 21.2 % and 22.6 % wet moisture contents (w.b.) were dried at 50 ºC and 60ºC for either 5, 10, 15 or 20 minutes, followed by tempering at 25ºC for 45 minutes. Each drying cycle was repeated until the rice seeds were dried to 12.0 % (w.b.). The drying rate was improved and the total in-dryer time was reduced in the intermittent drying when compared to continuous drying, due to the tempering process. The seed vigor was significantly reduced by intermittent drying at 60 °C with all exposure times, although the seed still kept the ability to germinate for both rice cultivars. The intermittent drying at 50 ºC for 5 minutes per drying cycle preserved the seed vigor of Japonica rice well, while in Indica rice, the intermittent drying at 50 ºC up to 20 minutes could still be able to maintain the seed vigor.
Introduction: Language and globalization in South and Central Asian spaces
Authors: Bolander Brook , Mostowlansky Till
Published: August 2017

In this introduction, we outline our approach to the two main themes this interdisciplinary special issue brings together – language and globalization, and South and Central Asian spaces. Arguing for the importance of exploring these topics from multiple, complementary disciplinary angles (sociolinguistic, anthropological and historical), we delineate a conceptualization of language and globalization which both acknowledges the inextricable relationship between language (use and ideology) and processes of globalization (past and present); as well as the challenges this relationship poses for linguistic research. We thereby adopt a viewpoint which underscores the importance of not
The Role of Copyright in Creative Industry Development
Authors: Pager Sean A.
Published: August 2017

Does copyright foster the development of creative industries in developing countries? Drawing on case studies from Nigeria, India, and China, this Article sheds some light on these questions. It argues that copyright offers distinct advantages over alternative models. Moreover, copyright law need not function as a monolithic force. Copyright norms can govern some aspects of industry operations, while remaining largely absent in other domains. However, as industries develop, the benefits of copyright become more salient and the logic of copyright formalization exerts a gravitational pull.
Stability via successive approximation for nonlinear implicit fractional differential equations
Authors: Kucche Kishor D. , Sutar Sagar T.
Published: August 2017

In this paper we are concerned with nonlinear implicit fractional differential equations with initial conditions. We prove the existence and uniqueness results by using modified version of contraction principle. Further, our prime aim is to present various Ulam-Hyers stability and Eα-Ulam-Hyers stability results via successive approximation method.
A review of the comparative study of Mo Yan and Faulkner in China
Authors: Huang Xiuguo
Published: August 2017

Mo Yan’s multi-layered and allegorical tales were highly inspired by William Faulkner. Mo Yan’s semi-fictional Gaomi Northeast Township was often linked to William Faulkner’s fictional Yoknapatawpha, and he himself was extolled by the Chinese scholars to be “China’s Faulkner.” Inside China, there have emerged a great number of comparative studies on Faulkner and Mo Yan, which are usually conducted from the perspectives of literary forms, native-soil complex, attitudes towards tradition, the influence of local culture, and so on. However, despite the strong record of research on these two writers in China, there is still room for improvement in the study, for after the initial stage of the superficial and sporadic comparison between individual works, the comparative study of Faulkner and Mo Yanis in pressing need of comprehensive and systematic research of these criticisms.
Time of Day Differences in Neural Reward Functioning in Healthy Young Men
Authors: Byrne Jamie E.M. , Hughes Matthew E. , Rossell Susan L. , Johnson Sheri L. , Murray Greg
Published: August 2017

Reward function appears to be modulated by the circadian system, but little is known about the neural basis of this interaction. Previous research suggests that the neural reward response may be different in the afternoon; however, the direction of this effect is contentious. Reward response may follow the diurnal rhythm in self-reported positive affect, peaking in the early afternoon. An alternative is that daily reward response represents a type of prediction error, with neural reward activation relatively high at times of day when rewards are unexpected (i.e., early and late in the day). The present study measured neural reward activation in the context of a validated reward task at 10.00 h, 14.00 h, and 19.00 h in healthy human males. A region of interest BOLD fMRI protocol was used to investigate the diurnal waveform of activation in reward-related brain regions. Multilevel modeling found, as expected, a highly significant quadratic time-of-day effect focusing on the left putamen (p< 0.001). Consistent with the “prediction error” hypothesis, activation was significantly higher at 10.00 h and 19.00 h compared with 14.00 h. It is provisionally concluded that the putamen may be particularly important in endogenous priming of reward motivation at different times of day, with the pattern of activation consistent with circadian-modulated reward expectancies in neural pathways (i.e., greater activation to reward stimuli at unexpected times of day). This study encourages further research into circadian modulation of reward and underscores the methodological importance of accounting for time of day in fMRI protocols.

SIGNIFICANCE STATEMENTThis is one of the first studies to use a repeated-measures imaging procedure to explore the diurnal rhythm of reward activation. Although self-reported reward (most often operationalized as positive affect) peaks in the afternoon, the present findings indicate that neural activation is lowest at this time. We conclude that the diurnal neural activation pattern may reflect a prediction error of the brain, where rewards at unexpected times (10.00 h and 19.00 h) elicit higher activation in reward brain regions than at expected (14.00 h) times. These data also have methodological significance, suggesting that there may be a time of day influence, which should be accounted for in neural reward studies.
Effects of Selective Deafferentation on the Discharge Characteristics of Medial Rectus Motoneurons
Authors: Hernández Rosendo G. , Benítez-Temiño Beatriz , Morado-Díaz Camilo J. , Davis-López de Carrizosa María América , de la Cruz Rosa R. , Pastor Angel M.
Published: August 2017

Medial rectus motoneurons receive two main pontine inputs: abducens internuclear neurons, whose axons course through the medial longitudinal fasciculus (MLF), and neurons in the lateral vestibular nucleus, whose axons project through the ascending tract of Deiters (ATD). Abducens internuclear neurons are responsible for conjugate gaze in the horizontal plane, whereas ATD neurons provide medial rectus motoneurons with a vestibular input comprising mainly head velocity. To reveal the relative contribution of each input to the oculomotor physiology, single-unit recordings from medial rectus motoneurons were obtained in the control situation and after selective deafferentation from cats with unilateral transection of either the MLF or the ATD. Both MLF and ATD transection produced similar short-term alterations in medial rectus motoneuron firing pattern, which were more drastic in MLF of animals. However, long-term recordings revealed important differences between the two types of lesion. Thus, while the effects of the MLF section were permanent, 2 months after ATD lesioning all motoneuronal firing parameters were similar to the control. These findings indicated a more relevant role of the MLF pathway in driving motoneuronal firing and evidenced compensatory mechanisms following the ATD lesion. Confocal immunocytochemistry revealed that MLF transection produced also a higher loss of synaptic boutons, mainly at the dendritic level. Moreover, 2 months after ATD transection, we observed an increase in synaptic coverage around motoneuron cell bodies compared with short-term data, which is indicative of a synaptogenic compensatory mechanism of the abducens internuclear pathway that could lead to the observed firing and morphological recovery.

SIGNIFICANCE STATEMENTEye movements rely on multiple neuronal circuits for appropriate performance. The abducens internuclear pathway through the medial longitudinal fascicle (MLF) and the vestibular neurons through the ascending tract of Deiters (ATD) are a dual system that supports the firing of medial rectus motoneurons. We report the effect of sectioning the MLF or the ATD pathway on the firing of medial rectus motoneurons, as well as the plastic mechanisms by which one input compensates for the lack of the other. This work shows that while the effects of MLF transection are permanent, the ATD section produces transitory effects. A mechanism based on axonal sprouting and occupancy of the vacant synaptic space due to deafferentation is the base for the mechanism of compensation on the medial rectus motoneuron.
Stem cells make leukemia grow again
Authors: Bahr Carsten , Correia Nádia C , Trumpp Andreas
Published: August 2017

Leukemic stem cells were hypothesized to play a critical role in acute myeloid leukemia relapse, but data to support this were lacking. In a recent study elegantly combining sequencing with functional xenograft assays, Shlush et al () identified two distinct origins of leukemic relapse. They provided direct experimental evidence linking relapse to cancer stem cell clones already present before therapeutic intervention.
Kinetochore Components Required for Centromeric Chromatin Assembly Are Impacted by Msc1 in Schizosaccharomyces pombe
Authors: Gao Chenchao , Langbein Lauren , Kamal Fariha , George Anuja A , Walworth Nancy C
Published: August 2017

Eukaryotic chromosome segregation requires a protein complex known as the kinetochore that mediates attachment between mitotic spindle microtubules and centromere-specific nucleosomes composed of the widely conserved histone variant CENP-A. Mutations in kinetochore proteins of the fission yeast Schizosaccharomyces pombe lead to chromosome missegregation such that daughter cells emerge from mitosis with unequal DNA content. We find that multiple copies of Msc1—a fission yeast homolog of the KDM5 family of proteins—suppresses the temperature-sensitive growth defect of several kinetochore mutants, including mis16 and mis18, as well as mis6, mis15, and mis17, components of the Constitutive Centromere Associated Network (CCAN). On the other hand, deletion of msc1 exacerbates both the growth defect and chromosome missegregation phenotype of each of these mutants. The C-terminal PHD domains of Msc1, previously shown to associate with a histone deacetylase activity, are necessary for Msc1 function when kinetochore mutants are compromised. We also demonstrate that, in the absence of Msc1, the frequency of localization to the kinetochore of Mis16 and Mis15 is altered from wild-type cells. As we show here for msc1, others have shown that elevating cnp1 levels acts similarly to promote survival of the CCAN mutants. The rescue of mis15 and mis17 by cnp1 is, however, independent of msc1. Thus, Msc1 appears to contribute to the chromatin environment at the centromere: the absence of Msc1 sensitizes cells to perturbations in kinetochore function, while elevating Msc1 overcomes loss of function of critical components of the kinetochore and centromere.
Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents
Authors: Flynn Joseph T. , Kaelber David C. , Baker-Smith Carissa M. , Blowey Douglas , Carroll Aaron E. , Daniels Stephen R. , de Ferranti Sarah D. , Dionne Janis M. , Falkner Bonita , Flinn Susan K. , Gidding Samuel S. , Goodwin Celeste , Leu Michael G. , Powers Makia E. , Rea Corinna , Samuels Joshua , Simasek Madeline , Thaker Vidhu V. , Urbina Elaine M. ,   SUBCOMMITTEE ON SCREENING AND MANAGEMENT OF HIGH BLOOD PRESSURE IN CHILDREN
Published: August 2017

These pediatric hypertension guidelines are an update to the 2004 “Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents.” Significant changes in these guidelines include (1) the replacement of the term “prehypertension” with the term “elevated blood pressure,” (2) new normative pediatric blood pressure (BP) tables based on normal-weight children, (3) a simplified screening table for identifying BPs needing further evaluation, (4) a simplified BP classification in adolescents ≥13 years of age that aligns with the forthcoming American Heart Association and American College of Cardiology adult BP guidelines, (5) a more limited recommendation to perform screening BP measurements only at preventive care visits, (6) streamlined recommendations on the initial evaluation and management of abnormal BPs, (7) an expanded role for ambulatory BP monitoring in the diagnosis and management of pediatric hypertension, and (8) revised recommendations on when to perform echocardiography in the evaluation of newly diagnosed hypertensive pediatric patients (generally only before medication initiation), along with a revised definition of left ventricular hypertrophy. These guidelines include 30 Key Action Statements and 27 additional recommendations derived from a comprehensive review of almost 15 000 published articles between January 2004 and July 2016. Each Key Action Statement includes level of evidence, benefit-harm relationship, and strength of recommendation. This clinical practice guideline, endorsed by the American Heart Association, is intended to foster a patient- and family-centered approach to care, reduce unnecessary and costly medical interventions, improve patient diagnoses and outcomes, support implementation, and provide direction for future research.
Lozano-Vásquez, Andrea y Meléndez, Germán, comps. Convertir la vida en arte: una introducción histórica a la filosofía como forma de vida
Authors: Acevedo-Zapata Diana María
Published: August 2017

Lozano-Vásquez, Andrea y Meléndez, Germán, comps. Convertir la vida en arte: una introducción histórica a la filosofía como forma de vida. Bogotá: Universidad Nacional de Colombia, 2016. 389 pp.
“Handspro” bailando “Staying ‘ Alive” en el parque Morazán
Authors: Ortiz Chinchilla Jimmy
Published: August 2017

En este trabajo se pretende realizar un análisis de los elementos estéticos, técnico-corporales, sociales y políticos del movimiento danzado llamado “Breakdance” como arte callejero en el contexto nacional. Cabe aclarar que el tema se desarrolló desde de la perspectiva postmoderna, como experiencia cultural y condición social asumiendo conesto que es un concepto en construcción y como triunfo del neoliberalismo. Se analizará, además, la dinámica de la globalización, las formas y valores socioculturales presentes, así como la política neoliberal que trae consecuencias en los planteamientos y puesta en marcha de políticas públicas sobre las juventudes en Costa Rica. Se partirá, además de laespecificidad de la danza como arte que involucra la corporeidad del bailarín y sus implicaciones con el “Otro” social, por lo que la exclusión y discriminación serán dos conceptos que permitirán discernir las consecuencias prácticas de este tipo de actividad artística en la dinámica social. El objeto de estudio partirá de la trayectoria y currículum de la agrupación nacional de “breakdance” llamada “Handspro”.
Interculturalidade: construção de um pensamento pós-abissal
Authors: Vieira Barboza Isabella , Ramos Lamar Adolfo
Published: August 2017

Este trabalho visa a questionar a interculturalidade, com base no pensamento abissal e da colonialidade. Infelizmente, esse pensamento ainda está presente na Sociedade Brasileira não nos termos do acordo territorial, mas as negociações têm imposto a nossa sociedade e reproduzir continuamente. Hoje, esses pensamentos são apresentados no poder do racismo de maneiras diferentes. Portanto, para entender o tema deste trabalho, foi realizado um estudo da literatura para entender a raiz do pensamento abissal e sua relação com o multiculturalismo. Este estudo conclui que não há nenhuma maneira de separar o conceito de construção intercultural do conceito de um postabisal, capaz de superar o conceito de superioridade ou inferioridade pensamento. Transcender o pensamento mais multicultural, multiculturalismo incentiva uma interrupção das barreiras abissais, integrando grupos diferentes.
Condiciones de control, fuentes de contaminación y agentes desinfectantes empleados en una sala blanca
Authors: Vargas Valverde Erick
Published: August 2017

Una sala blanca o limpia es un área científicamente construida para trabajar en condiciones de asepcia, es así como las instalaciones nucleares, microelectrónicas, alimentarias, cosméticas, farmacias de formulación magistral, de terapia celular, las instalaciones de metrología, laboratorios de investigación tecnológica y las industrias farmacéuticas las utilizan. Específicamente en la industria farmacéutica, para garantizar las condiciones en los laboratorios donde se realizan las pruebas de esterilidad, se deben conocer los principales factores de control, operación y desinfección de las salas blancas, los cuales mantienen la concentración de partículas en niveles aceptables de contaminación. Factores como la presión y la recirculación interna del aire en la sala, sumados con la regulación de la temperatura, humedad y el control de la vestimenta del personal de trabajo son indispensables para una adecuada operación. Por su parte, desinfectantes a base de alcohol, fenol, cloro, amonio cuaternario, formaldehido, glutaraldehido, peróxido de hidrógeno y peráctidos son comúnmente utilizados para la desinfección de paredes, pisos y mesas de trabajo. Este trabajo contempla los principales factores de control, operación y desinfección de una sala blanca aplicados en un laboratorio de pruebas de esterilidad en la industria farmacéutica.
Bem viver, Ubuntu e a Sociomuseologia: contribuições para descolonizar a Educação Museal
Authors: De Siqueira Juliana Maria
Published: August 2017

A Sociomuseologia é permanentemente instigada a expandir e aprofundar seus conceitos e suas práticas. Se continua relevante o propósito da Mesa Redonda de Santiago do Chile – de firmar o compromisso dos museus com a vida, a dignidade humana e a justiça social – no cotidiano das instituições isso é em alguma medida realizado e simultaneamente negado. Nos cenários de opressão, aflora sempre uma resistência; onde quer que a liberdade se realize, será possível ampliá-la. Por meio da reflexividade, descobrimos os pontos cegos que nos impedem de perceber as exclusões e os limites desse fazer-conhecer. Olhar para o campo desde a perspectiva dos povos originários do Sul pode contribuir para sua descolonização. Esta comunicação tem como intento explorar os aportes da Biologia do Conhecer, do Bem- Viver e do Ubuntu para a fundamentação da Educação Museal numa mirada participativa e emancipadora.
Medicamentos genéricos: su importancia económica en los sistemas públicos de salud y la necesidad de estudios in vitro para establecer su bioequivalencia
Authors: Segura Campos Luis Alfredo
Published: August 2017

El concepto de medicamento genérico muchas veces no queda claro puesto que se confunde con medicamentos que son simples copias o son engaños. Debe quedar claro que para la mayoría de las agencias regulatorias del mundo un medicamento genérico es el que ha demostrado intercambiabilidad por uno de referencia o innovador siempre y cuando se hayan efectuado estudios de bioequivalencia. Surge entonces el sistema de clasificaciónn biofarmacéutica (SCB) que es un herramienta que permite crear algunas bioexcepciones o fundamentar los estudios de bioequivalencia en ensayos in vitro en vez de los costosos ensayos in vivo utilizando perfiles de disolución. Debe también resultar claro que un fármaco del tipo genérico sólo puede ser comercializado si las patentes de los originales han caducado, estas patentes son la garantía de los laboratorios innovadores de que en un período que puede ser hasta de 20 años puedenrecuperar la inversión en estudios clínicos que garantizan la seguridad, eficacia y calidad del medicamento en el mercado y que son la razón por la que sus precios son más elevados. Por otro lado, la factura que deben pagar los sistemas de salud pública de países emergentes es elevada, por lo tanto los medicamentos genéricos son una alternativa viable por tener precios de mercado mucho más bajos que los originales, eso sí siempre que se hayan efectuado ensayos de intercambiabilidad y calidad, con una política de registro y farmacovigilancia estricta y bien estructurada. Tomandoen cuenta que muchas veces un cambio en la apariencia de los medicamentos genéricos pueden causar dudas en los pacientes en cuanto a calidad, seguridad y eficacia redundando en poca adhesión a los tratamientos.
Ecología del Homo Sapiens y su relación sociocultural
Authors: Barquero Arroyo Marco
Published: August 2017

Muchos individuos de la especie Homo sapiens consideran estar separada del resto de criaturas del Reino Animal. Esto implica que hay un desligamiento de las relaciones entre el ser humano y el entorno natural, cuyas causas son variadas y sus consecuencias suelen ser nocivas. El presente ensayo repasa las características ecológicas del ser humano, como por ejemplo el número de individuos, su distribución en el planeta, la esperanza de vida y las relaciones con otras especies y el entorno. Además, se analizan las repercusiones socioculturales que generan las acciones de nuestra especie sobre el entorno. Las características ecológicas del ser humano evidencian que no deberíamos considerarnos como la especie más importante del planeta, sino más bien, como integral de los ecosistemas. No obstante, los impactos producidos por el ser humano sobre los ecosistemas, tanto sobre los elementos abióticos como los bióticos, suelen ser nocivos y afectan a todas las especies, incluida la nuestra. Por lo tanto, se sugiere una reevaluación de nuestro estatus como especie y nuestra función en el ambiente.
Guía para la presentación de trabajos en la Revista Pensamiento Actual
Authors: Pensamiento Actual Revista
Published: August 2017

Objetivo. El objetivo de la Revista Educación de la Universidad de Costa Rica es difundir la investigación científica y promover la reflexión académica en diversos campos del quehacer universitario.
ФЕРМЕНТАТИВНИЙ МЕТОД ВИЗНАЧЕННЯ БІОЛОГІЧНОЇ ЦІННОСТІ МОЛОЧНИХ ПРОДУКТІВ ІЗ ЗЕРНОВИМ ІНГРЕДІЄНТОМ ДЛЯ ДИТЯЧОГО ХАРЧУВАННЯ
Authors: РУДАКОВА Т. В.
Published: August 2017

Під час створення продуктів для дитячого харчування визначальне значення має адекватна біологічна цінність. Саме вона є одним з головних критеріїв оцінювання доцільності використання тих або інших компонентів. Біологічну цінність продуктів визначають біологічними, хімічними і ферментативними методами. Ферментативні методи визначення біологічної цінності білка є одним з простих і в той же час об’єктивним методом визначення його здатності до розщеплення протеолітичними ферментами у шлунково-кишковому тракті.   Перетравлювання білків у шлунково-кишковому тракті (ШКТ) лімітує засвоювання амінокислот організмом. Частково гідролізовані білки, що надходять із шлунку до тонкого кишечника, перебуваючи там обмежений час, повинні швидко гідролізуватись до амінокислот та засвоїться: потрапляння амінокислот до товстого кишечника рівноцінне їх втраті для організму. Тому біологічна цінність білків продукту визначається ступенем і швидкістю перетравлювання протеазами ШКТ, засвоюванням амінокислот та подальшою утилізацією на пластичні потреби організму. Ефективність гідролізу харчових білків залежить від амінокислотного складу, конформації молекул, умов технологічного оброблення продукту.  В статті представлено дослідження щодо біологічної цінності сировини, яка використовується для виробництва молочних продуктів дитячого харчування (сиру кисломолочного, незбираного молока, концентрату сироваткових білків, рисового борошна) та готових продуктів. Для визначення біологічної цінності продуктів ферментативним методом модифіковано конструкцію приладу для гідролізу білків.   Доведено, що уведення у рецептури концентрату сироваткових білків та рисового борошна являється доцільним, так як дозволяє отримати кисломолочний продукт «Віталакт» та пасту сиркову з кращими показниками перетравлюваності. Показано, що швидкість перетравлення білків молочних продуктів для дитячого харчування вища ніж складників цих продуктів окремо. При цьому перетравлюваність молочних білків була вищою за рослинних. Так, показник перетравлюваності для молочних продуктів дитячого харчування  становив в межах 70-77 %, а для рисового борошна – 41,8 %.
Setting $PATH on UA HPC v1
Authors: L Hurwitz Bonnie , Youens-Clark Ken
Published: August 2017

Set up your Unix PATH so you can find important tools on the HPC for the class.
Features of pregnancy with gestational diabetes mellitus and prediction of diabetic fetopathy
Authors: Akhmetova Elena S. , Lareva Natalia V. , Mudrov Victor A. , Gergesova Ekaterina E.
Published: August 2017

Gestational diabetes mellitus (GDM) and its consequences for the mother and child represent a serious not only medical, but also an economic problem. The urgency of studying this problem also lies in the fact that the number of pregnant women suffering from this disease is progressively increasing. The aim of the study was to study the risk factors and features of the course of pregnancy and childbirth in women with gestational diabetes mellitus, as well as to improve methods for diagnosing and predicting the development of diabetic fetopathy (DF). The work was carried out in 3 stages: 1 — prospective study of the course of pregnancy and childbirth in 104 women with GDM and in 50 pregnant women without GDM (control group); 2 — determination in the peripheral blood of the pregnant women of both groups of the level of glycemia, C-peptide, insulin, calculation of the insulin resistance index (HOMA-IR) with an assessment of the prognostic significance of these markers in the development of diabetic fetopathy; 3 — prediction of the development of diabetic fetopathy using a mathematical model that includes risk factors, the results of laboratory and instrumental research methods for this pathology. It was found that the violation of carbohydrate metabolism during pregnancy promotes the development of a large number of obstetric complications and in 36.5% of cases leads to the birth of children with diabetic fetopathy, which is manifested to a greater degree by macrosomia (30%), which increases the risk of perinatal complications and worsens the course of the period newborn in the future. An increase in the level of C-peptide was diagnosed in 87% of pregnant women with gestational diabetes, and an increase in the insulin resistance index in 93%, in contrast to the control group, where these indicators were 4 and 6%, respectively (p < 0.05). Using discriminant analysis, it was determined that the threshold for predicting the development of DF should be considered an increase in HOMA-IR above 7 with a confidence of 73%, but the level of C- peptide does not have a predictive value. The mathematical model, including risk factors, data of laboratory and instrumental methods for studying carbohydrate metabolism in the mother and fetus, created using regression analysis, reflects the probability of development of diabetic fetopathy in pregnant women with gestational diabetes with an accuracy of 91.4%, which will help to prevent this complication in at an earlier stage through insulin therapy.
The problem of "thin" endometrium in reproductive medicine: experience of application of recombinant Interleukin-2 to prepare patients to assisted reproductive technologies programs
Authors: Lysenko Olga V. , Rozhdzestvenskaya Tatyana A.
Published: August 2017

Introduction. “Thin” endometrium is known affect negatively to reproductive function. Treatment of “thin” endometrium remains a problem and subject of future major studies.

Aim. To justify the possibility of applying of recombinant interleikina-2 person late reproductive age patients with “thin” endometrium before using assisted reproductive technologies.

Matherials and Methods. We examined a total of 64 late reproductive age women. Three groups of patients were analyzed. The first investigated group included 25 women with histologically proven chronic endometritis; the comparison group included 20 patients with endometrium of the early proliferative phase; the second investigated group included 19 patients with “thin” endometrium, with indications for the conduct of in vitro fertilization. Interleukin 2, interleukin-4, tumor necrosis factor alpha, interleukin-1β, Interleukin-6, interleukin-8, interleukin-10, IFN-γ concentrations were determined by enzyme linked immunosorbent assay in serum and aspirates from the uterine cavity in first investigated group and comparison group. Vaginal ultrasonic examination was made for women of second investigated group in first and second phase of menstrual cycle before and after recombinant human interlejkinom-2 treatment. Statistical data processing was performed using application software package Statistica 6.0 (StatSoft, Ink. 1994–2001), adapted for biomedical research. P < 0.05 was considered significant.

Results. Were found that concentrations of interleukin 2, interleukin-10 significantly reduced and concentrations of tumor necrosis factor alpha, interleukin-1β, Interleukin-6 and interleukin-8 significantly increased in aspirates from the uterine cavity in women of late reproductive age with chronic endometritis. All changes occur at the local level in chronic endometritis. Endometrial thickness a statistically significant increase after use of recombinant human interlejkinom-2 in patients with infertility and chronic endometritis.

Conclusions. Application of recombinant interleukin-2 in patients with “thin” endometrium can become optimal schema therapy, which requires further study.
Compared diagnostic value of proteinuria definition applying different methods at pregnants with preeclampsia
Authors: Mozgovaya Elena V. , Androsova Natalya E. , Dorofeicov Vladimir V.
Published: August 2017

Colorimetric method of protein determination in urine with use of pyrogallol red (PGR) has certain advantages over a routine method of proteinuria determination with use of sulfosalicylic acid (SSA) which is still applied in most clinics in the Russian Federation. For the purpose to determinate the diagnostic significance of proteinuria estimation by different methods at pregnants with preeclampsia, conducted a comparative research of proteinuria levels at 68 pregnants with preeclampsia and at 15 healthy pregnant by two methods: with sulfosalicylic acid and with pyrogallol red. At the same patients the diagnostic significance of protein/creatinine ratio was evaluated when using the method with PGR. It was revealed that proteinuria determination with PGR- method had authentically higher sensitivity, and proteinuria indices when using this method corresponds to the criteria for evaluation of preeclampsia severity specified in the Ministry of Health Russian Federation Order No. 572n 2012 and the Clinical Recomandations “Hypertensia during pregnancy. Preeclampsia. Eclampsia” (2012). In case of proteinuria determination by method with SSK it is necessary to consider lower sensitivity of the method and adhere to earlier classification of preeclampsia (gestosis) where proteinuria more 1 g/l was regarded as the symptom of severe preeclampsia. Confirmation of the diagnostic significance of protein/creatinine ratio needs further researches.
Molecular mechanisms of regulation of uterine leiomyoma growth
Authors: Antsiferova Yulia S. , Voronin Dmitry N. , Sotnikova Natalya Yu. , Malyshkina Anna I.
Published: August 2017

Background: to elucidate the molecular mechanisms, regulating growth and proliferation of leiomyoma cells, the estimation of the activity of PR-A and PR-B isoforms of progesterone receptor and PI3K/Akt and MAPК kinases, participating in signal transduction from sex steroids and growth factors, has the special interest.

Aim of the work: to investigate the character of the expression of mRNAs of PR-A and PR-B isoforms of progesterone receptor in leiomyomas of different size and different intensity of cellular proliferation, and to elucidate the relationship between the PR-A and PR-B synthesis and activation of PI3K/Akt and MAPК signaling pathways in tumour tissue.

Materials and Methods. The examination of the PR-A, PR-B, Akt, PTEN, ERK and Ki67 mRNAs expression in normal myometrium and leiomyoma tissues of 29 women with uterine leiomyoma was performed using RP-PCR.

Results. It was found that in general the leiomyoma tissue was characterized by the high level of PR-A, PTEN and ERK mRNAs expression comparing to the miometrium. Distinctive characteristic of the small leiomyomas and leiomyomas with low proliferative activity was the highest synthesis of PR-A isoform of progesterone receptor. In large leiomyomas and in proliferating Ki67+ leiomymas the significant increase of ERK mRNA expression was seen.

Conclusion. Activation of the PR-A isoform of progesterone receptor and MAPK/ERK signaling pathway associated with the inhibition of PI3K/Akt signaling due to high synthesis of PTEN plays the important role in mechanisms, regulating leiomyoma growth.
The case of abdominal delivery in acute heteroimmune drug indused thrombocytopenia
Authors: Shirokov Dmitriy M. , Bolotskikh Vyacheslav M. , Dzhanashia Manana M. , Eremeeva Dina R. , Korostelev Yury M. , Vartanova Irina V. , Blinov Aleksey E.
Published: August 2017

The secondary gravida pregnant patient with uterine scar after previous cesarean section was treated with parenteral methamizol sodium due to renal colic and acute thrombocytopenia suddenly occurred. There were supposed that this condition had been drugs induced heteroimmune thrombocytopenia. The indications for planned cesarean section were breech presentation of large fetus in patient with uterine scar. However, uterine contractions appeared in 38/39 weeks and it was decided to deliver the patient urgently after appropriate preparing. The treating of severe thrombocytopenia was substitutive — thromboconcentrate and plasma transfusion and pathogenetic — using of dexamethasone and human immunoglobulin. After transfusion of one dose of thromboconcentrate and two doses of plasma the level of thrombocytes had reached of 21 × 109/л and it was decided to start cesarean section which was performed successfully in conditions of total combined anesthesia with tracheal intubation and pulmonary ventilation. The recovery of thrombocytes quantity occurred in postoperative period with continuing using of steroid therapy.
How de Holy Grail ended up in O Cebreiro, Galicia
Authors: Kuefler Mathew
Published: August 2017

Una leyenda moderna dice que el Santo Grial fue escondido a O Cebreiro en Galicia. Me encontré con una posible explicación de esta en la realización de investigaciones sobre San Gerardo de Aurillac, santo francés del siglo décimo. Había en la Edad Media un convento dedicado a él, mas tarde abandonado. Fue también un milagro recordado por haber tenido lugar allí, donde un sacerdote, no convencido de la transubstanciación, vio el pan y el vino ritual transforma en carne y sangre. Cuando San Gerardo se mencionó a los peregrinos que pasaran por O Cebreiro, cofundaron su nombre –Sant Gral en gallego– con el cáliz del milagro y lo mal identificaron como el Santo Grial-Sant Grial en gallego. La leyenda se elaboró por Ramón Cabanillas, poeta gallego moderno, de manera nostálgica que recuerda San Gerardo y sus biografías medievales: una mezcla de devoción religiosa con un código marcial.
Versos y política en el siglo XVIII : la oda al Conde de Aranda, de Stanislao Konarski
Authors: Gómez Urdáñez José Luis , Fernández López Jorge , Taracha Cezary , Stefanczyk Andrzej
Published: August 2017

El abate Konarski escribió una oda homenajeando al conde de Aranda cuando el gran político aragonés dejaba la embajada de Varsovia y se dirigía a Portugal, donde debía mandar las tropas que habían invadido el vecino país en 1762. Los resonantes triunfos que esperaba del conde el escolapio polaco no llegaron a producirse, pues la campaña militar fue un desastre; tampoco la oda era una ingenuidad del latinista polaco, pues escondía nada menos que el intento partidario de los valedores del rey Estanislao Augusto Poniatowski de estrechar lazos con las monarquías borbónicas.
Los carlistas de Valencia : la reacción en una ciudad liberal (1833-1840)
Authors: Caridad Salvador Antonio
Published: August 2017

En este artículo se analiza la fuerza del carlismo en una ciudad mayoritariamente liberal, como era Valencia en 1833-1840. Para ello se hace un recorrido biográfico por los carlistas más destacados de la ciudad, pasando después a estudiar la importancia del carlismo entre las clases populares de Valencia, a partir de los casos individuales que conocemos. De esta forma se observa que, aunque el apoyo a don Carlos era minoritario, no por eso dejaba de tener un gran número de seguidores en la capital del Turia.