bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH MODEL PROBLEM BASED LEARNING TERHADAP HASIL BELAJAR SISWA SUBTEMA KEBERAGAMAN BUDAYA BANGSAKU
Authors: Nurhasanah  , Suhendra  , Sri indriani Rini
Published: April 2023

The influence of the implementation of problem based learning model on student learning outcomes subtheme of my nation’s cultular diversity. This study uses a two group design quasi experimental approach at Leuwisadeng elementary school. The subject of this study were student in grades IV-A and IV-B of Leuwisadeng  state elementary school with a total of 59 student. This research was conducted in the odd semester of the 2022/2023 academic year. The results of this study indicate that there is a effect of the application of the problem based learning model on student learning outcomes in subtheme 1 of the cultural diversity of my nation. This can be seen from the N-gain value in the experimental class group which has an average value of 69, while in the control class the average is 48. In the results of hypothesis testing that have been carried out are that HO is rejected an Ha is accepted because tcount (4.91) > ttabel (200247). Thus, the result of the research that have been carried out can be concluded that the application of the problem based learning model has a positive influence on student learning outcomes in subtheme 1 cultural disversity of my nation.
Clinical trials tranformation intiative-decentralized clinical trials: a review article
Authors: Jakkula Shirisha , Pasupuleti Pravalika , C.S Mujeebuddin , Gaur Ravindra Pratap , Patil Sujay S
Published: April 2023

In clinical research, Decentralized clinical trials (DCTs) can provide opportunities to maximize efficiencies. Unlike the traditional clinical trial model, Decentralized Clinical Trials (DCTs) promote telemedicine, mobile/local healthcare providers (HCPs), mobile/web-based technology, and direct distribution of Investigational Medicinal Products (IMP) to patients, among other things.  Hence, DCTs are in the spotlight as technology, infrastructure, and knowledge providing a backbone in clinical research.

Background: Advances in electronic communication, data storage, emerging technologies, and biosensor development provides new opportunities to exchange information, such as the patient is tested from their home locations and are with locations distant from the investigator. Trials that take place at locations distant from the investigator (i.e., spectrum: CCTs → Hybrid Models → DCTs) in any or all study-related procedures and data is collected electronically fall in the category of the decentralized clinical trial. Trials should be designed to integrate the current healthcare system of the study subject, optimize convenience for study subjects and take advantage of existing programs and data sources including The study subjects themselves through the utilization of telecommunication, videoconferences, mobile or internet-based tools for patient reporting, mobile technology tools and biosensors. Local healthcare providers, home-based healthcare services, pharmacies, clinics, regional hospitals, their perceived obstacles have impeded the widespread use of mobile devices in clinical trials. To encourage solutions to these challenges, The Clinical Trial Transformation Initiative (CTTI) has released best practices and practical methods to advance solutions to these issues that clinical trial sponsors can now use.

Conclusion: Decentralized clinical trials are not only operationally feasible and show high recruitment rates, have better compliance, lower dropout rates, and are conducted faster. DCT meets the goal of the industry in being low-risk, high returns trials and can offer a reliable, time-based, and cost-effective approach.
A case report on ischemic Mitral regurgitation
Authors: P Kranthi Priya , M Ramya , V Sushma Sri , M Mounica , Amit Kumar
Published: April 2023

Ischemic Mitral regurgitation is a leakage of blood backward through the mitral valve each time the left ventricle contraction. Patients are often ill with significant hemodynamic instability (Acute) needs urgent medical treatment. During normal cycle mitral valve (bicuspid valve) opens and closes normally. But in mitral regurgitation mitral valve does not opens and closes properly. The blood  from right atrium moves to right ventricle then mitral valve does not closes properly leads to blood ejected back to right atrium which results in pulmonary edema and increases pulmonary hypertension. Ischemic Mitral regurgitation leads to complication of acute myocardial infraction and coronary artery disease
A review on yunis-varon syndrome
Authors: Ch Bhagya Sri , R Harshavardhini , V Syam Kumar , K Ramakrishna , A Venkata Shiva , Kadari Sowjanya
Published: April 2023

Yunis Varon Syndrome was first discovered by Emilio Yunis and Humberto Varon in the year 1980. It affects both genders in equal number. Most of the infants are with Cleidocranial dysplasia, ectodermal anomalities, distal aphalangia. By the characteristic features which including deformity of the pelvis, dislocation of hips , bone fracture, urinary tract abnormalities, central nervous system abnormalities by this they have reported the condition as Yunis Varon Syndrome. This is an autosomal recessive inherited multisystem disorder due to FIG4 gene mutations, consanguineous marriages, Lysosomal defects, which may leads to improper in the functioning of organs in the infants. Metabolic disorders in which abnormal growth due to some toxic substances in the body. Affected people with this syndrome may experience breathing problems, abnormalities in the skeletal system, congenital heart defects. Genetic testing for mutation can be detected through diagnosis. In some conditions they may also be detected before birth of the baby that is prenatally by ultrasonography.Many of the infants did not survive beyond on year. Genetic counselling will be of benefit for affected individuals and their families.
Transfusion-Related Acute Lung Injury (TRALI): A Narrative Literature Review
Authors: Novera Hana , Russilawati Russilawati  , Dessy Mizarti
Published: April 2023

Transfusion-related acute lung injury (TRALI) is defined as the onset of respiratory distress in a patient after receiving a blood component transfusion. So far, TRALI is considered a rare complication in the field of blood transfusion. However, in the last decade, there has been a shift in perspective. Currently, the US Food and Drug Administration recognizes the syndrome as the leading cause of transfusion-related death. This literature review aims to describe TRALI and its prevention strategies. Understanding the pathogenesis of TRALI drives prevention strategies from a blood bank perspective. A major breakthrough in efforts to reduce the incidence of TRALI was excluding female donors from the high plasma volume product, which resulted in an approximately two-thirds reduction in incidence. However, this strategy has not completely eliminated complications of transfusion. In recent years, research has identified patient-associated risk factors for the development of TRALI and empowered clinicians to take an individualized approach to patients requiring transfusion.
Stereotactic radiosurgery with oxygen radiosensitization in the treatment of multiforme glioblastoma
Authors: Gryazov A.B. , Ivchuk V.P. , Kozarenko T.M. , Shcherbina O.V.
Published: April 2023

Glioblastoma multiforme (mGBM) is the most frequent and most primary malignant neoplasm of the central nervous system. Despite current standard treatment protocols such as aggressive surgical resection, radiation therapy, and chemotherapy, the aggressive nature of mGBM results in poor survival. This is largely due to its radioresistance, due to the hypoxia of tumor cells, which are resistant to various chemotherapy regimens, including radiation therapy.
Purpose. To assess the effectiveness of radiosurgical treatment of recurrence in patients with mGBM after surgical resection and chemotherapy, using oxygen radiosensitization.
Materials and methods. Our study included 26 patients with relapsed mGBM who underwent SRS with oxygen radiosensitization. 12 patients were the control group, without radiosensitization. The study primarily determined the role of oxygen radiosensitization of the tumor, the dose of radiosurgical treatment, the volume of the tumor, and the degree of oxygenation according to MRI data (BOLD programs). Oxygenation was carried out using the Oxy 6000 oxygenator. The effectiveness of radiosurgical treatment was assessed by overall and recurrence-free survival, as well as by the degree of treatment toxicity.
The results. Median overall survival (OSS) was 20 months in patients who received SRS with radiosensitization compared with 12 months in those who received SRS without radiosensitization. Relapse-free survival (FFS) in the study group was 15 months, against 8 in the control group (p = 0.004; X 2 = 8.166).
Conclusion. SRS is a fairly effective and reliable strategy in the treatment of recurrence of glioblastoma multiforme after surgical resection of the tumor and chemoradiotherapy. Radiosensitization with oxygen during SRS of hypoxic radioresistant glioblastomas improves overall survival by 60.0% and recurrence-free survival by 53.3% compared to the control group. Oxygen is a powerful radiosensitizer that significantly increases the radiosensitivity of tumor cells by increasing the oxygen saturation of hypoxic cells.
Mie kering dengan substitusi tepung telur ayam ras (Gallus gallus domesticus)
Authors: Melianti Sherina , Ulfah Triana , Adiputra Rachmat , Quddus Ati Atul , Fizriani Atia , Hariadi Hari
Published: April 2023

This research was purposed to determine the effect of the addition of egg powder on physicochemical properties and to determine the best formulation treatment according to organoleptic properties. This study used a one-factor Randomized group design (RAK) with 4 treatments (A0: 100% flour, A1: 90% flour + 10% egg flour, A2 : 80% flour + 20% egg flour, A3 : 70% flour + 30% egg flour) and 3 repetitions. The results showed that the combination of adding egg flour had no significant effect on chemical characteristics (ash content), on physical characteristics the combination of adding egg flour had a significant effect on physical properties. The best formulation based on organoleptic properties was the addition of 10% egg flour on texture parameters 5.00 (liked), aroma 4.80 (liked), taste 5.13 (liked), color 5.45 (liked).
On the psychometric evaluation of cognitive control tasks: An Investigation with the Dual Mechanisms of Cognitive Control (DMCC) battery
Authors: Snijder Jean-Paul , Tang Rongxiang , Bugg Julie M. , Conway Andrew R. A. , Braver Todd S.
Published: April 2023

The domain of cognitive control has been a major focus of experimental, neuroscience, and individual differences research. Currently, however, no theory of cognitive control successfully unifies both experimental and individual differences findings. Some perspectives deny that there even exists a unified psychometric cognitive control construct to be measured at all. These shortcomings of the current literature may reflect the fact that current cognitive control paradigms are optimized for the detection of within-subject experimental effects rather than individual differences. In the current study, we examine the psychometric properties of the Dual Mechanisms of Cognitive Control (DMCC) task battery, which was designed in accordance with a theoretical framework that postulates common sources of within-subject and individual differences variation. We evaluated both internal consistency and test–retest reliability, and for the latter, utilized both classical test theory measures (i.e., split-half methods, intraclass correlation) and newer hierarchical Bayesian estimation of generative models. Although traditional psychometric measures suggested poor reliability, the hierarchical Bayesian models indicated a different pattern, with good to excellent test–retest reliability in almost all tasks and conditions examined. Moreover, within-task, between-condition correlations were generally increased when using the Bayesian model-derived estimates, and these higher correlations appeared to be directly linked to the higher reliability of the measures. In contrast, between-task correlations remained low regardless of theoretical manipulations or estimation approach. Together, these findings highlight the advantages of Bayesian estimation methods, while also pointing to the important role of reliability in the search for a unified theory of cognitive control.
Okul Psikolojik Danışmanlarının Algılarına Göre Okul Yöneticilerin Etik Liderlik Davranışlarının İncelenmesi
Authors: AKIN Mehmet Ali , İŞ Engin , ANUŞTEKİN Mehmet
Published: April 2023

Öz: Bu araştırmanın amacı, okul psikolojik danışmanlarının algılarına göre okul yöneticilerinin etik liderlik davranışlarını sergileme düzeylerinin bazı demografik değişkenlere göre istatistiksel olarak anlamlı bir şekilde farklılaşıp farklılaşmadığının ortaya çıkarılmasıdır. Araştırma nicel araştırma teknikleri kullanılarak yapılan betimsel bir araştırmadır. Çalışmada öncelikle liderlik ile ilgili kavramsal çerçeve kullanılmış. Ardın da liderlik ile ilgili güç kaynaklarından etik boyuta değinilmiştir. Her geçen gün önemi ve toplumda kabulü artan etik liderliğin alt boyutları ayrıntılı şekilde detaylandırılmıştır. Bu alt boyutlar çalışmanın daha iyi anlaşılması ve somutlaştırılması noktasında önem taşımaktadır. Araştırma evreni 2020-2021 eğitim öğretim yılında Diyarbakır, Mardin, Batman ve Şanlıurfa illerinde görev yapan 3000 okul psikolojik danışmanından oluşmaktadır. Araştırmanın örneklemi, basit seçkisiz örnekleme tekniğine göre seçilen 300 okul psikolojik danışmanından oluşmaktadır. Veriler, etik liderlik ölçeği uygulanarak elde edilmiştir. Elde edilen verilerin nasıl bir dağılım gösterdiğini tespit etmek için uygulanan normallik testi ile basıklık-çarpıklık katsayısı sonucunda parametrik t-testi, One-Way Anova testleri uygulanmıştır. Öğretmenlerin mesleki kıdemleri ve yaş değişkenine göre okul yöneticilerinin etik liderlik davranışlarına ilişkin algı düzeylerinde anlamlı fark bulunmuş; eğitim düzeyi değişkenine göre okul yöneticilerinin etik liderlik davranışlarına ilişkin algıları arasında anlamlı fark çıkmamıştır. Araştırmada okul psikolojik danışmanlarının yöneticilerinin etik liderlik davranış algılarının yüksek olduğu bulgularına ulaşılmıştır. Okul yöneticilerinin etik liderlik davranışlarının yüksek çıkması okullarda etik liderliğe dayalı ilişki biçiminin önemsendiğini göstermesi bakımından önemlidir. Araştırma sonucunda; araştırmaya katılan öğretmenlere göre okul yöneticilerinin yüksek düzeyde etik liderlik rollerini yerine getirmekteler. Müdürlerin yönetim süreçleri konusunda öğretmenlerin mesleki gelişimlerine katkı sağlayabilecek düzeyde yetiştirilmeleri, iletişim becerilerinin geliştirilmesi öğretim sürecinde istenen sonuçların elde edilmesi açısından önemlidir.
Ana Dili ve Yabancı Dil Öğretiminde Dijital Öykü Kullanımı Araştırmalarının İçerik Analizi
Authors: SARAR KUZU Tülay , YALÇINALP Serpil
Published: April 2023

İletişimin temel aracı olan dil, yaşamın her alanında, her meslek ve her disiplin açısından yaşamsal bir öneme sahiptir. Dil öğretimi içinde ana dili ve yabancı dil öğretimi, ilköğretim süreciyle başlayan örgün eğitimde genel akademik başarıyı etkilemenin yanı sıra yaşam boyu düşünme becerilerinin de geliştirildiği etkin bir süreçtir. Bu bağlamda eğitim sürecinde yaparak, yaşayarak öğrenme ve etkin öğrenme temelli uygulamalara ihtiyaç vardır. Üst düzey düşünme becerilerini geliştiren ve öğrenme-öğretme süreçlerini etkinleştirmeyi amaçlayan eğitim teknolojisi ürünlerinden biri de dijital öyküdür. Farklı düzeylerde öğrenen kitlesine yönelik ve farklı disiplinlerde kullanımı olan bu teknolojinin tüm dünyada olduğu gibi ülkemizde de farklı yönleri ile incelendiği çalışmalar gün geçtikçe artmaktadır. Bu çalışmanın amacı, Türkiye’de Türkçenin ana dili öğretiminde ve yabancı dil öğretiminde dijital öykü kullanımına yönelik yapılan araştırmaların ana dili ve yabancı dil öğretimi bağlamında belirlenen ölçütler çerçevesinde karşılaştırmalı olarak incelenmesidir. Bu amaçla Google Akademik ve TR Dizin indeksleri kapsamında Türkiye’de 2016-2019 yılları arasında yapılmış, dil öğretiminde dijital öykü kullanımına yönelik 373 çalışmaya ulaşılmış, yapılan eleme sonucu 17 çalışma incelemeye alınmıştır. Doküman incelemesi yoluyla elde edilen veriler belirlenen ölçütler doğrultusunda, nitel araştırma yaklaşımlarından betimsel içerik analizi tekniği kullanılarak çözümlenmiştir. İnceleme sonucunda yapılan çalışmaların büyük oranda (13 makale) ana dili öğretimi alanında gerçekleştirildiği, çoğunluğunun 2017 ve 2019 yıllarında yapıldığı, büyük oranda nitel araştırma ve deneysel araştırma yönteminin kullanıldığı, bunu durum ve tarama yöntemlerinin izlediği, veri toplama aracı olarak da görüşme yönteminin sıklıkla tercih edildiği ve araştırma kapsamında dijital öyküleme yönteminin çoğunlukla yazma alanında uygulandığı belirlenmiştir.
Okul Gelişimi Değerlendirme Uygulamalarının İncelenmesi
Authors: DAŞCI SÖNMEZ Elif , GOKMENOGLU Tuba
Published: April 2023

Her okulun kendine özgü dinamikleri, ihtiyaçları ve özellikleri mevcuttur. Bu nedenle, her okula uyum gösterecek bir okul gelişim modelinden ve değerlendirme yaklaşımından söz etmek mümkün değildir. Okulların gelişimine uygun değerlendirmelerin çok sayıda çeşitlendiği düşünüldüğünde farklı ülkelerde farklı uygulamaların olması kaçınılmazdır. Doküman incelemesi deseninde tasarlanan bu çalışmada, öğrenci nüfus yoğunluğu ülkemiz ile benzer olan, kişi başına düşen reel Gayri Safi Yurtiçi Hasılanın dünya sıralamasında ilk 30’da yer almış ve PISA 2015 ve 2018 sınavında fen bilimleri, matematik ve okuma alanlarının en az birinde Ekonomik Kalkınma ve İşbirliği Örgütü (OECD) ülkeleri ortalaması ya da üzerinde bir performans göstermiş ülkelerin (Birleşik Krallık (İngiltere), Japonya, Almanya, İtalya ve Fransa) okul gelişimi değerlendirme amaçları ve uygulamaları karşılaştırmalı olarak incelenmiştir. Bulgular, değerlendirmenin amacı, değerlendirme türü, veri toplama yöntemi, değerlendirme ekibi ve değerlendirme sonuçlarının etkisi kategorileri altında raporlanmıştır. Elde edilen sonuçlar, okulların dış ve iç değerlendirmelerinin, okulların her anlamda gelişimine katkıda bulunacak şekilde tasarlanması gerektiğini ortaya koymaktadır.
Okul Öncesi Öğretmenlerinin Matematik Etkinliklerinde İç ve Dış Mekân Kullanımına İlişkin Görüşleri ve Uygulamaları
Authors: ATA DOĞAN Selda , AKMAN Berrin
Published: April 2023

Araştırmada, okul öncesi öğretmenlerinin matematik etkinliklerinde iç ve dış mekân kullanımına ilişkin görüş ve uygulamaları nitel araştırma yöntemlerinden açıklayıcı durum çalışması modeliyle incelenmiştir. Çalışma grubu, Ankara ili Çankaya, Etimesgut ve Yenimahalle ilçelerinde yer alan bağımsız anaokullarında görev yapan 18 okul öncesi öğretmeninden oluşmaktadır. Veriler, yarı yapılandırılmış görüşme formu ve öğretmenlerin son bir ay içerisinde programlarında matematik etkinliklerine yer verme durumlarına yönelik bir durum çizelgesi aracılığıyla toplanmıştır. Araştırma sonucunda öğretmenlerin matematik etkinliklerini planlarken çocuk-etkinlik-ortam odaklı hususlara dikkat ettikleri, matematik etkinliklerinde en çok sayılar konusuna yer verdikleri, matematik etkinliklerini daha çok iç mekânda uyguladıkları belirlenmiştir. Ayrıca öğretmenlerin matematik etkinliklerinde kullandıkları materyallerin, matematik etkinlikleri uygulamalarını engelleyen faktörlerin ve kaygılarının mekâna göre farklılık gösterdiği tespit edilmiştir. Okul öncesi öğretmenlerinin hem iç hem de dış mekânda uygulanan matematik etkinliklerinin çocukların gelişimine katkı sağladığını düşündükleri fakat bazı nedenlerden dolayı dış mekânda daha az uygulama yaptıkları ortaya konmuştur. Bu sonuçlardan yola çıkarak, okulların dış mekânlarının çocukların gelişimine uygun öğrenme ortamları olarak düzenlenmesiyle ve dış mekânda uygulama etkinliklerinin eğitim akışı içerisinde yer alan rutinlere dâhil edilmesiyle öğretmenlerin dış mekân uygulamalarının arttırılabileceği düşünülmektedir.
Uzaktan Eğitim Tutum Ölçeği: Geçerlik ve Güvenirlik Çalışması
Authors: KORUCUK Murat
Published: April 2023

Bu çalışmada üniversite öğrencilerinin uzaktan eğitime yönelik tutumlarının belirlenebilmesi için geçerliği ve güvenirliği sınanmış Likert türünde bir ölçek geliştirilmesi amaçlanmıştır. Uzaktan Eğitim Tutum Ölçeği (UETÖ) ön uygulamasında 227 öğrenciden elde edilen verilere uygulanan AFA soncunda 32 maddelik üç boyut belirlenmiştir. Bu boyutlar Bilişsel Alan Boyutu (13 madde; Açıklanan Varyans: %32.12), Duyuşsal Alan Boyutu (15 madde; Açıklanan Varyans: %10.01) ve Davranışsal Alan Boyutu (4 madde; Açıklanan Varyans: %8.03) şeklinde sıralanabilir. UETÖ’nin toplam açıkladığı varyans ise %51.16’dır. UETÖ ile son aşamada 340 öğrenciden elde edilen verilere uygulanan DFA sonucundaki uyum indeksleri CFI=.90, GFI=.85, AGFI=.85, RMSEA=.058, SRMR=.10, TLI=.90, χ2/sd=2.148 şeklindedir. UETÖ’nin ölçüt geçerliğinin sınanabilmesi amacıyla alt boyutlar ile ölçek bütününe ait korelasyon katsayıları hesaplanmış ve ilgili boyutlar arasında yüksek düzeyde ve pozitif yönlü bir ilişki tespit edilmiştir. Diğer taraftan ölçek son uygulaması ile elde edilen verilerin güvenirliği de sınanmış ve Cronbach Alfa değeri Bilişsel Alan Boyutu için: .90, Duyuşsal Alan Boyutu için: .91, Davranışsal Alan Boyutu için: .86 ve ölçek tamamı için .94 iken; iki yarı test: 1. Kısım: .89 ve 2. Kısımı: .92 olarak belirlenmiştir. Sonuç olarak bu çalışmada geçerliği ve güvenirliği sınanmış “Uzaktan Eğitim Tutum Ölçeği” geliştirilmiştir.
Ders Denetimi Uygulamaları İçeren bir Mesleki Gelişim Modeli Önerisi: Okul Temelli Yansıtıcı Matematik Koçluğu
Authors: TOKER Zerrin , DOĞAN Muhammed Fatih
Published: April 2023

Kaliteli eğitimin bir bileşeni olarak etkili öğretim geleneksel eğitim anlayışında öğrencilerin sınav başarısı ile birebir eşlenirken günümüzde etkili öğretim uygulamaları çok daha kapsamlı olarak ele alınmaktadır. Eğitim-öğretim süreçlerindeki bu yenilikçi bakış açısı doğrultusunda öğretmenlerin öğretim pratiklerinde de yenilikler ve gelişimler söz konusudur. Öğretmenlerin mevcut öğretim uygulamalarında değişiklikler ve yeni uygulamalara uyum sağlaması noktasında mesleki gelişime ihtiyaç duydukları açıktır ve bu ihtiyaç pek çok disiplin alanı için geçerli olduğu gibi matematik öğretmenleri için de geçerlidir. Bu çalışmada matematik öğretmenlerinin mesleki gelişimlerine yönelik bir model matematik koçluğu ele alınmıştır. Çalışmada uluslararası alan yazında büyük ölçekte koçluk, özelde ise matematik koçluğu ile ilgili çalışmalardan elde edilen bulgular ile koçluğun ne olduğu ve neden ihtiyaç duyulduğu, koçluk türleri, koçluk sürecindeki temel unsurlar, koçluk süreci ve uygulanma şekli, etkili koçluk süreci için destekleyici mekanizmalar, sürecin zorlukları ele alınmıştır. Bu bilgiler ışığında Türkiye’de matematik koçluğu sürecinde kullanılabilecek okul temelli bir mesleki gelişim modeli olarak yansıtıcı matematik koçluğu modeli önerisi geliştirilmiştir.
The use of antioxidants in the treatment of Graves’ Disease: evaluating the results
Authors:   Department of Infectious Diseases and Epidemiology, Skin and Venereal Illnesses, ”I. Horbachevsky” Ternopil National Medical University, Ternopil, Ukraine, Ostapchuk Vladyslava Oleksandrivna , Ostapchuk Vadym Andriiovych ,   Department of Infectious Diseases and Epidemiology, Skin and Venereal Illnesses, ”I. Horbachevsky” Ternopil National Medical University, Ternopil, Ukraine, Shidlovskyi Oleksandr Viktorovich ,   Department of Surgery, ”I. Horbachevsky” Ternopil National Medical University, Ternopil, Ukraine, Sheremet Michael Ivanovich ,   Surgical Department 1, Bukovinian State Medical University, Chernivtsi, Ukraine
Published: April 2023

Topicality. Accelerated metabolism in Graves' disease causes the development of oxidative stress, which significantly affects the clinical course and treatment results. Purpose. This study was conducted to evaluate the effect of treatment with thyrosol and thyrosol in combination with antioxidants, in particular vitamins C and E, on indicators of thyroid hormone function (thyroid-stimulating hormone and thyroxine) and oxidative stress (malondialdehyde and total antioxidant capacity). Material and method. The clinical study was performed on 41 patients with newly diagnosed Graves' disease of moderate severity, aged from 21 to 43 years, who were divided into two groups. The control group consisted of 19 patients who received thyrosol for treatment. The main group included 22 patients who were treated with thyrosol in combination with vitamins C and E. Examinations were carried out upon inclusion in the program and one and two months after the start of treatment. Results. The conducted studies showed that in the course of treatment, the indicators of malic dialdehyde gradually decreased from 21.3±0.4 (17.3–29.2) to 10.31±0.1 (9.72–10.82) and thyroxine from 37.7±0.5 (31.2–42.7) to 15.31±0.2 (13.20–20.52) and the total antioxidant capacity increased from 0.69±0.04 (0.52–0.79) to 1.58±0.1 (1.48–1.61), thyroid- stimulating hormone from 0.01±0.004 (0.07–0.001) to 2.31±0.1 (0.90–3.52). These changes were more pronounced in the main group compared to the control group during the study one month and two months after the start of treatment. Conclusions. Thus, antioxidant supplements can be used to improve thyroid function in hyperthyroid patients by enhancing antioxidants and restoring the oxidant-antioxidant balance.
CAD/CAM in Orthodontics –A Magnanimous Journey
Authors: V Manisha , Rajesh Nallakunta
Published: April 2023

Orthodontics is one branch of dentistry which deals with dynamic manipulation and function of the stomatognathic system. Likewise, it has to witness the dynamic changes in its diagnosis method and treatment planning. The field of orthodontics has witnessed many revolutionary techniques and evolved enormously in terms of benefiting the patient. CAD/CAM is one promising methodology that has shown a significant impact in modern dentistry and surpassed some of the challenges an orthodontist has been facing all these years. It has changed the view through which we see the patient’s condition. The application of 3D technology allows the practitioner and patient to utilize virtual treatment planning software to better identify case objectives and visualize treatment outcomes. CAD/CAM has many applications in orthodontics, which include aids for diagnosis and treatment planning, clear aligner treatment, customized lingual appliances, customized brackets with patient-specific torque, machine-milled indirect bonding jigs, robotically bent archwires, indirect bonding systems, customization of orthodontic appliances like distalization appliance etc., Acceleration of orthodontic treatment (OT) has received growing attention in recent years, especially in adult patients.Digital workflow is the current trend in orthodontic practice and has speckled every aspect of orthodontics in terms of documentation, study casts, analysis of dental malocclusion, smile designing, treatment planning and fabrication of orthodontic appliances. The current article aimed to establish a narrative description of the digital workflow and applications of the CAD/CAM process in Orthodontics.
Advances in the management of post-endodontic pain: a review
Authors: Varma K Meghana , Satish Rajulapati Kalyan , S Sajjan Girija , Varma K Madhu , Panitini Bhavani , Ponnada Naveena
Published: April 2023

This review describes the management of post-endodontic pain pharmacologically and non-pharmacologically. Acute periapical inflammation brought on by endodontic treatment-related chemical, mechanical, and/or microbiological damage to the periapical region causes postoperative pain, which is multifactorial in nature. A wide range of technical and pharmacological techniques are taken into consideration and proposed to control post-operative endodontic pain, the present study primarily comprised an overview of systematic reviews, randomized clinical trials,and invitrostudies summarizing advancement in the management of post- operative endodontic pain.
CURRENT APPLICATIONS AND CHALLENGES OF THE INTERNET OF THINGS
Authors: Dallaev Rashid , Pisarenko Tatiana , Ţălu Ştefan , Sobola Dinara , Majzner Jiří , Papež Nikola
Published: April 2023

The concept of the Internet of Things is capable of making a giant leap in the economy, including research in the field of computer science, network technologies, microelectronics and sensor technology. Combined with the technological developments of nanotechnology and robotics, IoT can play a central role in the industrial revolution by creating economic relations between machines and connecting the economy of people and machines, solving a number of problems that humanity is facing. All devices controlled via the Internet are elements of the Internet of things. The IoT has allowed various possibilities for all countries to improve life quality and the technological ideas for efficiency, productivity, security, and profit. An integrated security system is a giant step towards the improved economy. The concept of IoT plays a decisive role in the further development of the infocommunication industry. This is confirmed both by the position of the International Telecommunication Union (ITU) and the European Union on this issue, and by the inclusion of the Internet of Things in the list of breakthrough technologies in the United States, China and other countries. Thus, this article will go over the current state of the IoT as well as describe which devices and industries stand to benefit from the advantages it brings. Additionally, statistical data on the actual trends and investments into IoT across the world are also provided.
Chemical Modeling of Orion Nebula Cluster Disks: Evidence for Massive, Compact Gas Disks with Interstellar Gas-to-dust Ratios
Authors: Boyden Ryan D. , Eisner Josh A.
Published: April 2023

The stellar cluster environment is expected to play a central role in the evolution of circumstellar disks. We use thermochemical modeling to constrain the dust and gas masses, disk sizes, UV and X-ray radiation fields, viewing geometries, and central stellar masses of 20 class II disks in the Orion Nebula Cluster (ONC). We fit a large grid of disk models to 350 GHz continuum, CO J = 3 − 2, and HCO+
J = 4 − 3 Atacama Large Millimeter/submillimeter Array observations of each target, and we introduce a procedure for modeling interferometric observations of gas disks detected in absorption against a bright molecular cloud background. We find that the ONC disks are massive and compact, with typical radii <100 au, gas masses ≥10−3
M
⊙, and gas-to-dust ratios ≥100. The interstellar‐medium‐like gas-to-dust ratios derived from our modeling suggest that compact, externally irradiated disks in the ONC are less prone to gas-phase CO depletion than the massive and extended gas disks that are commonly found in nearby low-mass star-forming regions. The presence of massive gas disks indicates that external photoevaporation may have only recently begun operating in the ONC; though it remains unclear whether other cluster members are older and more evaporated than the ones in our sample. Finally, we compare our dynamically derived stellar masses with the stellar masses predicted from evolutionary models and find excellent agreement. Our study has significantly increased the number of dynamical mass measurements in the mass range ≤0.5 M
⊙, demonstrating that the ONC is an ideal region for obtaining large samples of dynamical mass measurements toward low-mass M-dwarfs.
A Comprehensive Model of Morphologically Realistic Cosmic Dust Particles: An Application to Mimic the Unusual Polarization Properties of the Interstellar Comet 2I/Borisov
Authors: Halder Prithish , Sengupta Sujan
Published: April 2023

The cosmic dust particles found in space are mainly porous aggregates of smaller grains. Theoretically, these aggregates are replicated using fractal geometry, assuming a cluster of spheres. Although the light scattering response of cosmic dust aggregates has been thoroughly studied using clusters of spherical grains in the past few decades, the effect of irregularities on the surface of each grain in an entire aggregate has mostly been neglected. We introduce, for the first time, a visually realistic cosmic dust model that incorporates a mixture of rough fractal aggregates (RFA) and agglomerated debris (Solids) to replicate the unusual polarization–phase curve observed in the case of the interstellar comet 2I/Borisov at multiple wavelengths. The authenticity of the RFA structures has been verified by replicating light scattering results of circumstellar dust analogs from the Granada Amsterdam Light Scattering Database. We demonstrate that the light scattering response from the RFA structures has a very close resemblance to the experimental values. Finally, we model the observed polarization–phase curve of the interstellar comet 2I/Borisov using a mixture of RFA and solid particles. The best-fit data indicate the presence of a higher percentage of porous RFA structures (80%) owing to the fact that the comet carries a higher percentage of small and highly porous pristine cosmic dust particles. Further, the model indicates that the unusually steep polarimetric slope and the high dust-to-gas ratio in newer comets are mainly due to a higher porous-to-compact ratio.
An Extensive Catalog of Early-type Dwarf Galaxies in the Local Universe: Morphology and Environment
Authors: Paudel Sanjaya , Yoon Suk-Jin , Yoo Jaewon , Smith Rory , Chhatkuli Daya Nidhi , Kumar Bachchan Rajesh , Aryal Binil , Adhikari Binod , Adhikari Namuna , Sedain Amrit , Sheikh Sharup , Dhital Sarashwati , Giri Ashutosh , Baral Rabin
Published: April 2023

We present an extensive catalog of 5405 early-type dwarf (dE) galaxies located in the various environments, i.e., clusters, groups, and fields, of the local universe (z < 0.01). The dEs are selected through visual inspection of the Legacy survey’s g–r–z combined tricolor images. The inspected area, covering a total sky area of 7643 deg2, encompasses two local clusters (Virgo and Fornax), 265 groups, and the regions around 586 field galaxies of M

K
< −21 mag. The catalog aims to be one of the most extensive and publicly accessible collections of data on dEs, despite its complex completeness limits, which may not accurately represent its statistical completeness. The strength of the catalog lies in the morphological characteristics, including nucleated, tidal, and ultradiffuse dEs. The two clusters contribute nearly half (2437 out of 5405) of the dEs, and the 265 groups contribute 2103 dEs. There are 864 dEs in 586 fields, i.e., ∼1.47 dEs per field. Using a standard definition commonly used in literature, we identify 100 ultradiffuse galaxies (UDGs), which compose ∼2% of the dE population. We find that 40% of our sample dEs harbor a central nucleus, and among the UDG population, a majority (79%) are nonnucleated. About 1.3% of dEs suffer from ongoing tidal disturbance by nearby massive galaxies, and only 0.03% show a sign of recent dwarf–dwarf mergers. The association between dEs and their nearest bright neighbor galaxies suggests that dEs are more likely created where their neighbors are non-star-forming ones.
CMR Exploration. I. Filament Structure with Synthetic Observations
Authors: Kong 孔 Shuo 朔 , Ossenkopf-Okada Volker , Arce Héctor G. , Klessen Ralf S. , Xu Duo
Published: April 2023

In this paper, we carry out a pilot parameter exploration for the collision-induced magnetic reconnection (CMR) mechanism that forms filamentary molecular clouds. Following Kong et al., we utilize Athena++ to model CMR in the context of resistive magnetohydrodynamics (MHD), considering the effect from seven physical conditions, including the ohmic resistivity (η), the magnetic field (B), the cloud density (ρ), the cloud radius R, the isothermal temperature T, the collision velocity v

x
, and the shear velocity v

z
. Compared to their fiducial model, we consider a higher and a lower value for each one of the seven parameters. We quantify the exploration results with five metrics, including the density probability distribution function (ρ-PDF), the filament morphology (250 μm dust emission), the B–ρ relation, the dominant fiber width, and the ringiness that describes the significance of the ringlike substructures. The exploration forms straight and curved CMR filaments with rich substructures that are highly variable in space and time. The variation translates to fluctuation in all five metrics, reflecting the chaotic nature of magnetic reconnection in CMR. A temporary B ∝ ρ relation is noticeable during the first 0.6 Myr. Overall, the exploration provides useful initial insights into the CMR mechanism.
Unveiling the Mechanism for the Rapid Acceleration Phase in a Solar Eruption
Authors: Zhong Ze , Guo Yang , Wiegelmann Thomas , Ding M. D. , Chen Yao
Published: April 2023

Two major mechanisms have been proposed to drive the solar eruptions: the ideal magnetohydrodynamic instability and the resistive magnetic reconnection. Due to the close coupling and synchronicity of the two mechanisms, it is difficult to identify their respective contribution to solar eruptions, especially to the critical rapid acceleration phase. Here, to shed light on this problem, we conduct a data-driven numerical simulation for the flux rope eruption on 2011 August 4, and quantify the contributions of the upward exhaust of the magnetic reconnection along the flaring current sheet and the work done by the large-scale Lorentz force acting on the flux rope. Major simulation results of the eruption, such as the macroscopic morphology, early kinematics of the flux rope and flare ribbons, match well with the observations. We estimate the energy converted from the magnetic slingshot above the current sheet and the large-scale Lorentz force exerting on the flux rope during the rapid acceleration phase, and find that (1) the work done by the large-scale Lorentz force is about 4.6 times higher than the former, and (2) decreased strapping force generated by the overlying field facilitates the eruption. These results indicate that the large-scale Lorentz force plays a dominant role in the rapid acceleration phase for this eruption.
Sexual dimorphism in excess power index of four North American native bees (Hymenoptera, Andrenidae, Apidae, and Halictidae)
Authors: Vigueira Patrick A. , Vigueira Cynthia C. , Campbell Joshua W. , Ladner Samia , Hayes Gabrielle , Riser Elizabeth
Published: April 2023

A multitude of hymenopteran species exhibit sexual dimorphism for simple traits, such as color, size, or antennal segment number. These differences can reflect selection for specialized biological roles, many of which have not been documented for the majority of bee and wasp species. The excess power index (EPI) is an estimate of insect flight performance that is inferred by the combination of several morphological characteristics. We compared the female and male EPIs in four species of native bees: Agapostemon virescens Fabricius, Andrena carlini Cockerell, Melissodes bimaculata Lepeletier and Xylocopa virginica L.. While females of each species had a significantly larger whole body mass, males had a significantly larger EPI. A larger body mass for females is associated with egg laying abilities and foraging behavior. Male fitness may be dependent on EPI; males that have greater flight capacity can travel further or remain in flight for longer time periods in search of mates.
Nursing Practice Variations in Pain Management in Older Adults With Dementia Admitted to an Acute Geriatrics Unit During the COVID-19 Pandemic
Authors: Minaya-Freire Alícia , Subirana-Casacuberta Mireia , Pou-Pujol Gemma , Ramon-Aribau Anna
Published: April 2023

The current retrospective descriptive study evaluated nursing practice variations on pain management in older adults with dementia admitted to an acute geriatrics unit (AGU) before (2018) and during (2021) the coronavirus disease 2019 (COVID-19) pandemic. Data were gathered from electronic health records. Pain intensity was evaluated a median of 1.9 times per day of stay in the pre–COVID-19 sample, whereas in the COVID-19 sample, the median was 0.7 times per day of stay. Median number of analgesic administrations per day of stay and mean percentage of clinical care records that mentioned pain were higher in patients admitted during the pandemic. Variations in nursing care organization in the AGU due to the COVID-19 pandemic had an impact on the patterns of pain management nursing practice in older adults with dementia. [
Research in Gerontological Nursing, 16
(4), 173–182.]
Improvement Opportunities for PAINReportIt
®
Delivered on a Wireless Tablet: Rated by Black Older Men With Low Back Pain
Authors: Fullwood Dottington , Means Sydney , Stickley Zachary L. , Elie-Turenne Marie-Carmelle , Wilkie Diana J.
Published: April 2023

Health care professionals and researchers can implement technology to improve older adults' acceptability of providing health information and to better include older adults in sharing information with health providers. However, older adults' engagement with technology remains low. This study focused on 60 Black older men (mean age = 70 years,
SD
= 6 years) with low back pain who completed the 13-item Computer Acceptability Scale after using the PAINReportIt
®
software on an Apple iPad
®
. On average, the sample found it acceptable to use PAINReportIt
®
software to share their pain or discomfort but that this was no replacement for oral dialogue with their health care provider. These findings contribute valuable information about the acceptability of using technology and indicate potential opportunities to improve PAINReportIt
®
software. Community interventions with acceptable tablet devices can offer new insight into collecting pain or discomfort data in populations with low presence in clinical research studies. [
Research in Gerontological Nursing, 16
(3), 108–114.]
Exploring the Feasibility of a Decentralized Autonomous Organization (DAO) as a New Model for Economic Governance in the Blockchain Era
Authors: Raja V.  , Subashree S.
Published: April 2023

Decentralized autonomous organizations (DAOs) are a new type of organization that are run using blockchain technology and are designed to operate without the need for traditional management structures. In this research project, the authors explored the feasibility of using DAOs as a new model for economic governance in the blockchain era. The authors examined the key features and functions of DAOs, assessed the potential benefits and challenges of using these organizations as a model for economic governance, and considered the legal and regulatory implications of DAOs. The authors also examined case studies of existing DAOs and analyzed their successes and failures in order to identify best practices for implementing and operating DAOs effectively. The findings suggest that DAOs have the potential to disrupt traditional models of economic governance by providing a new way for organizations to operate and make decisions in a transparent and decentralized manner. However, there are also challenges and limitations to using DAOs as a model for economic governance.
“How Can I Correct What I Don't Know?”
Authors: Borràs Judith , López-Serrano Sonia
Published: April 2023

While providing language learners with written corrective feedback (WCF) is a widespread methodology among L2 teachers, classroom-based studies in which feedback practices are fully integrated into the curriculum are still scarce. In addition, most of what we know about feedback provision and use comes from data gathered from learners at intermediate and advanced levels, while low-level learners are an under-researched group. The present classroom-based study investigates the incorporation of direct and indirect metalinguistic explanations (ME) by 27 low-level EFL first-year university students of tourism, as well as their views on WCF. Results show that (i) low-level learners were able to correct most of their mistakes when given ME, (ii) vocabulary-related mistakes were equally resolved through both types of ME while grammar mistakes benefited more from direct ME, and (iii) low-level learners perceived ME as highly useful, particularly those which were direct.
The Presence of Literary Education in the Curriculum Document Essential Learnings – Portuguese
Authors: Balça Ângela
Published: April 2023

The book chapter focuses on the reading and analysis of the Portuguese curriculum document Essential Learning – Portuguese. This document regulates the teaching and learning in Portuguese subject, and, in this chapter, the authors address the document from 1st to 4th grade. This document is divided into several specific domains, but this chapter will analyse, in detail, the domain of literary education. The reading and analysis of this document will lead to reflection on and understanding of how literary education is presented in this official text, the objectives what are outlined in it, what learning proposals are suggested to teachers for their update in daily teaching practice, and what texts are advised for the work in the classroom with literary reading.
The Role of Festivals in Destination Branding
Authors: Keskin Emrah , Sezen Nevres , Kaya Özge
Published: April 2023

Destinations are areas visited by tourists, containing natural/cultural attractions and openings to experience. The brand is an important reason for tourists to choose the destination. Destination branding contributes to the recognition of the destination and attracting more people. Events are organizations with a specific purpose, time, place, and theme predetermined. Festival events are events that have a specific theme in destinations and experiences which are made; this increases attractiveness, and contributes to destination marketing. Festivals are very important in increasing the recognition of destinations and attracting visitors. In this study, the contributions of festivals to the branding of destinations are written. As a result of the research, it was concluded that culture/art, gastronomy, and sports festivals are effective in destination branding. For this reason, festivals are events that contribute to the promotion of destinations, provide positive feedback about the destination, and encourage people to experience the destination.
Social Media Networks as an Effective Way to Promote Events
Authors: Kodaş Betül , Köz Ela Nazlı
Published: April 2023

Today, we have witnessed many events and festivals organized by different countries throughout the years. Some of these are organized locally, while the others are international. Social media networks are one of the essential marketing strategies which included advertising and promotion for event organizers. In this chapter, social media platforms, which can be used in promoting events and festivals, will be discussed conceptually by making a comprehensive literature review based on relevant literature. After reviewing the literature, this chapter will report how social media networks can be used as a promotional strategy for the event industry. So, this chapter aims to analyze in depth the relationship between social media platforms and promotions of events, and assessed how social media applications can be used to promote tourism events and festivals. At the end of the chapter, some practical implications will be presented to events marketers about social media tools used effectively to build effective promotional strategies for events and festivals.