bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative study of dinoprostone vaginal pessary versus PGE2 gel in labour induction: a randomised controlled study
Authors: Senthilvel Sharnitha , Vijayakrishnan Mala
Published: June 2022

Background: Induction of labour is a method of prematurely or artificially stimulating the onset of labour prior to onset of spontaneous labour. Different preparations of prostaglandin are available differing in their effectiveness, side effects, and price. But the most commonly used agent for induction of labour is the shorter acting PGE2 gel. However recently the longer acting PGE2 vaginal pessary has become available. The aim of this study is to compare the efficacy of PGE2 vaginal pessary versus intracervical PGE2 gel in induction of labour.Methods: A total of 170 antenatal patients were included in the study with 85 each group. Group A was given one dose of PGE2 vaginal pessary and group B was given PGE2 gel which was repeated for maximum of 3 doses at 6 hours interval. Patients were examined for cervical ripening, uterine contractions, fetal heart monitoring and complications. Augmentation, labour duration, type of delivery, complications were all noted for both groups.Results: The 56.47% in pessary group and 40% in gel group did not need augmentation which was statistically significant (p=0.029). There was no difference in the mode of delivery between two groups.Conclusions: In my study, comparing PGE2 gel with PGE2 vaginal pessary, there was no significant difference between them in efficacy and complication. The only significant difference noted in my study was reduced need for augmentation of labour in pessary than PGE2 gel.
Aggressive angiomyxoma of uterine corpus
Authors: Revanna Rachitha , Ramalingappa Padmasri , Kumar Divya Tumkur
Published: June 2022

Aggressive angiomyxoma (AA) is a rare slow growing mesenchymal tumour that preferentially involves the vulvovaginal, pelvic or perineal regions. It is called aggressive due its frequent local recurrences and infiltrative behavior. They occur most commonly in the reproductive age group in women. A 37 year old with AA of endometrial polyp, presenting with acute pain abdomen and friable, fleshy mass protruding out of introitus, precipitated by a dilatation and curettage for heavy menstrual bleeding. A clinical diagnosis of fibroid polyp with acute red degeneration was considered. There was a spontaneous expulsion of fleshy mass. HPE showed AA with features of torsion. MRI showed T2 heterogenous hyperintense mass lesion of 9 x 3 x 3.9 cm pedunculated polypoidal arising from upper anterior uterine wall. Hysterectomy specimen confirmed HPE findings of AA. Radiological studies and pathological evaluation aids in the diagnosis and planning of appropriate treatment of AA. Close and long term follow up of these patients should be emphasized due to high rate of local recurrence.
Pregnancy in rudimentary horn of unicornuate uterus: a rare case
Authors: Gawandi Prabhakar S. , Sathe Vijaysinh P. , Barkase Akanksha A. , Salunke Chetana U. , Gaikwad Priyanka , Patil Shivani
Published: June 2022

Congenital malformations of the female genital tract result from embryological maldevelopment of Mullerian or paramesonephric ducts. Mullerian duct anomalies (MDAs) are due to agenesis, defective fusion or resorption during embryological development. Unicornuate uterus results due to defective lateral fusion of Mullerian duct. This report discussed a case of pregnancy in rudimentary horn of unicornuate uterus which resulted in rupture of the horn. A patient 35 year old G2A1 with spontaneous conception with 4 months pregnancy came to emergency room with complaints of pain in abdomen and giddiness. On examination her general condition was moderate with pulse rate of 128 bpm, blood pressure of 90/60 mmHg, pallor was present. On per abdomen examination guarding, rigidity and diffuse tenderness was present. On per vaginum examination, uterus size could not be appreciated. Her haemoglobin level was 6 gm%. Ultrasonography of abdomen showed presence of unicornuate uterus with ruptured right horn with fetus in the abdominal cavity and presence of hemoperitoneum. Immediate resuscitative measures were performed, blood transfusion was started and simultaneously patient was shifted to operation theatre for exploratory laparotomy. Intraoperatively hemoperitoneum with unicornuate uterus with non communicating ruptured accessory horn on right side was present and foetus in peritoneal cavity was seen. Ruptured horn was excised and uterus was repaired. The accessory horn and foetus were sent for histopathology examination which was suggestive of placenta increta with gestational hypertrophy and hyperplasia of myometrium with normal tube and ovary. Patient tolerated the procedure well.
Sweet’s syndrome in pregnancy: a rare case report
Authors: Rawtani Harshal A. , Chandrashekhar Mubhachini , Phulpaghar Aditi , Mathur Ankita
Published: June 2022

Sweet’s syndrome (SS) is a steroid-responsive dermatological condition characterized by fever, neutrophilia and a classical tender erythematous skin rash. Pregnancy-associated SS is an extremely rare clinical entity and must be kept in mind while approaching a case of skin rash in pregnancy. We reported a rare case of SS in pregnancy with classical features and characteristic histopathological features of neutrophilic dermatosis that had a benign course, resolving with topical steroid treatment instead of the usual systemic steroids.
Mesentric vein thrombosis-bowel gangrene: a case series
Authors: Kumar Sampath , V. Vijayalakshmi , Jayasankar Nivetha , Ross Kannan
Published: June 2022

Mesenteric vein thrombosis is a condition often misdiagnosed due to its vague and misleading clinical presentation which can cause intestinal angina, infarct, peritonitis. In patients with no peritonitis or evidence of gangrene, they can be managed conservatively with anti-coagulants. In this case series we discuss about various methods of presentation of patients with mesenteric vein thrombosis admitted in Rajiv Gandhi government general hospital during a time frame of June 2020 to April 2022 under institute of general surgery and management followed for different patients.
Bilateral staghorn lithiasis: a case report
Authors: Orozco Cesar Alberto Ortiz , Gutiérrez Felix Osuna , Torres José María Zepeda , Fernandez Carlos Navarro , Solís Pablo Francisco Rojas , Ayala José Miguel Aceves , Casas Ashley Yael Sotelo
Published: June 2022

Staghorn stones are large branching stones that fill part of the entire renal pelvis and calyces and can be complete or partial depending on the degree of occupation of the collecting system. Although kidney stones are more common in men, coral stones are reported less frequently in men than in women and are usually unilateral. Due to the significant morbidity and potential mortality attributed to staghorn stones, prompt evaluation and treatment are imperative. In general, the gold standard treatment for coral stones is surgical treatment to achieve a stone-free collecting system and preserve renal function.
Neither appendicitis nor sigmoiditis; it is an appendagitis
Authors: Abbas Riyad
Published: June 2022

Appendagitis is defined as the inflammation of an omental appendix; it is a rare and often unrecognized cause of abdominal pain. Clinically, appendicitis simulates appendicitis or sigmoiditis; the evolution of radiology and in particular CT scans has facilitated the diagnosis and thus avoided hospitalization or even more unnecessary surgery. The treatment is conservative and relies on non-steroidal anti-inflammatory drugs and analgesics. The evolution is often favorable within 5 days of treatment on average. In reporting this clinical case, we tried to elucidate the diagnostic difficulty of this entity and to bring to light its different aspects through a brief review of the literature.
A rare case of 5-mm trocar-site hernias after laparoscopy rectopexy requiring surgical repair
Authors: Kadian Bhopesh , Singla Sanjeev , Virmani Rohit , Dwivedi Garima
Published: June 2022

The 5 mm trocar-site hernia are very rare complication of laparoscopic surgery and surgeons usually avoid fascial closure at 5 mm trocar-site. We show a case of laparoscopic anterior rectomeshplasty with early omental herniation through a 5 mm trocar-site and surgical repair, as well as an advice on whether or not to undertake a fascial closure of the 5 mm trocar-site.
Knowledge, attitude, and practice towards obesity among the general public in community settings of Tirupati: a cross-sectional study
Authors: Moorthy Srinivas B. R. , Subbaiahgari Harini , Sibbala Pavani , Kola Sravani , Kareem Liyakath
Published: June 2022

Background: Obesity and overweight are strongly linked to developing diabetes, hypertension, myocardial infarction, stroke, and endocrine disorders. Knowledge, attitude, and practices of the public are crucial in limiting the burden of obesity in the Indian community. The current study aims to assess the KAP of obesity among the general public of India. Methods: A community-based cross-sectional survey was conducted in the rural and urban areas of Tirupati city. Adults aged 18 years or above who are willing to participate, were included. A total of 300 subjects were enrolled and data was collected by using a pre-validated questionnaire. Variables like weight, height and KAP scores were obtained. Chi-square tests were used to associate demographics with good KAP towards obesity.Results: The findings show that more than half of the participants have good knowledge, and a positive attitude, but the practices are not optimal in dealing with obesity and management. Participants’ ages more than 40 years, presence of comorbidity, risk factors, and social habits are significantly associated with obesity and overweight. Obese are having good knowledge but normal-weight people are significantly associated with a positive attitude. Participants of normal weight, no risk factor, and no habits were significantly associated with rational practices.Conclusions: The study concludes that the participants had good knowledge and attitude toward obesity but the participants failed to practice controlling and preventing obesity. However, more efforts are required in creating awareness and educating the general population regarding physical activity, diet, and lifestyle in preventing obesity and its associated complications.
A rare case of thrombocytosis presentation in patient alcoholic liver disease with portal hypertension gastropathy: a stepwise evaluation
Authors: Wiryandari Ni Putu Nita , Suryana Ketut
Published: June 2022

Thrombocytosis is rarely found in patient with chronic liver disease (CLD). The possibility of reactive thrombocytosis could be due to sustained process such as iron deficiency anemia (IDA) because of occult bleeding. Occult bleeding can happen in CLD patient because of portal hypertension gastropathy (PHG) as complication of portal hypertension. A carefully evaluation of anemia can lead to underlying cause of disease, even in limited of supportive evaluation and some other confounding presentation that is thrombocytosis. We report a case of 54 years-old male patient with severe anemia. He had same symptom previously and got transfusion. Peripheral blood smear showed microcytic hypochromic anemia, anisocytosis, and poikilocytosis even pencil cells (pencil cells or cigar cells) with thrombocytosis. No symptom of acute inflammation setting and no clear blood loss was founded. As patient admitted to smoking and heavy alcohol consumption in the past, Ultrasound was performed for screening of underlying disease that cause occult bleeding. Ultrasound of the liver showed generally increased echogenicity suggestive of liver cirrhosis, splenomegaly and minimal ascites. Thus, our patient clinically be suggestive of CLD with portal hypertension that cause PHG.
Host–Parasite Associations and New Records of Chewing Lice (Phthiraptera: Amblycera, Ischnocera) from Raptors (Accipitriformes, Falconiformes, Strigiformes) Encountered in Egypt
Authors: Adly Eslam , Gustafsson Daniel R. , Nasser Mohamed , Baeshen Rowida , Kamal Mahmoud
Published: June 2022

Compared to many other groups of parasitic insects, the chewing louse fauna of the Middle East remains poorly known. Our attempts to alleviate this data deficiency include this report of lice that we found on five species of raptors in Egypt. From a total of 12 birds, we recovered four new records of chewing lice for Egypt: Colpocephalum milvi Tendeiro, Restivo & Demartis; Laemobothrion maximum (Scopoli); Colpocephalum percnopteri Price & Beer; and Laemobothrion vulturis (F.). We also recovered additional records for Egypt of Degeeriella regalis (Giebel), Colpocephalum turbinatum Denny, and Strigiphilus cursitans (Nitzsch [in Giebel]). The record of S. cursitans constitutes a new host association, Bubo ascalaphus Savigny. We provide measurements, taxonomic and ecological notes for all identified chewing louse specimens.
Differential Expression of Endocrine Regulatory Genes in Apis cerana and Apis mellifera (Hymenoptera: Apidae) at High Temperature
Authors: Li Xinyu , Ma Weihua , Du Yali , Xu Kai , Jiang Yusuo
Published: June 2022

Drastic changes in temperature can interfere with the normal physiological and biochemical activities of bees. Temperature stress affects the endocrine system of bees and induces a series of stress responses. However, the changes that occur in hormones in bees that are exposed to environmental stress are not well understood. In this study, we analyzed the expression patterns of four genes by quantitative real time reverse transcription polymerase chain reaction (qRT-PCR) in Apis mellifera L. and Apis cerana F. (Hymenoptera: Apidae) at different temperatures and different treatment times. The expression of juvenile hormone esterase, vitellogenin, corticotropin-releasing hormone binding protein, and adipokinetic hormone receptor genes was found to be increasingly affected by an increase in temperature and treatment time. Temperature stress affects the endocrine system of bees, and endogenous hormones in bees can respond to environmental stimuli. Our findings provide a basis for determining the mechanisms by which insect endocrine systems adapt to high temperatures.
Goat Milk: Compositional, Technological, Nutritional and Therapeutic Aspects: A Review
Authors: Hammam Ahmed R.A. , Salman Saleh M. , Elfaruk Mohamed S. , Alsaleem Khalid A.
Published: June 2022

Since the 1980s, a growing interest in goat milk was noticed due to the nutritional values and health benefits of this milk, which resulted in increasing goat populations and milk production worldwide. This comprehensive review elaborates on goat milk composition compared to other types of milk. It is also an overview of goat milk production, properties, nourishment value, applications in dairy products and potential health benefits. Goat milk composition and its characteristics are slightly different from other types of milk and can be utilized to manufacture many dairy products. Fresh goat milk and goat milk products (e.g., yogurt and kefir) were found to provide various potential health benefits, such as anti-inflammatory, preventing cardiovascular disease, anti-diabetic and antihypertensive, strengthening bones, boosting immunity and improving metabolism.
Aprovechamiento de la fibra de cabuya para el mejoramiento de las propiedades mecánicas de la mezcla tradicional de adobe en una unidad de albañilería en el distrito de Abancay, departamento de Apurímac
Authors:   , Lopez Daza Ximena Del Pilar , Torbisco Ascue Dasarella Bheatriz cc Asesores
Published: June 2022

La tierra es uno de los materiales más abundantes y accesibles usados por la población rural del mundo para la construcción de viviendas, las cuales son principalmente adobes y muros tapiales. El Perú no es la excepción, ya que tiene bajo costo y fácil preparación. Sin embargo, este material muestra una resistencia a la compresión y flexión muy baja y casi nula resistencia a la tracción, también se deteriora rápidamente debido a agentes externos como la humedad, erosión, corrosión, entre otros. En el mundo se han venido desarrollando investigaciones con el fin de mejorar las propiedades mecánicas y físicas del adobe. En el Perú contamos con una norma dedicada al diseño y construcción con tierra reforzada (RNE). En esta norma podemos encontrar las condiciones mínimas que debe tener el adobe para tener un comportamiento óptimo como material de construcción. Sin embargo, el adobe fabricado en la sierra sur del Perú no llega a la mínima resistencia por lo cual se plantea la adición de fibras naturales con el fin de mejorar sus propiedades. La presente investigación tiene como finalidad encontrar el porcentaje óptimo de adición de fibra de Cabuya en la elaboración de adobe para mejorar sus propiedades mecánicas en la ciudad de Abancay, Departamento de Apurímac. Se añadió fibra de cabuya en las unidades de adobe con paja con diferentes porcentajes. El porcentaje de adición de fibra de 1.75% nos dio como resultado un aumento en 40% y 12% en la resistencia a la compresión y flexión respectivamente.
Publicidad, remedios y tratamientos para la gripe en la prensa española (1918-1920)
Authors: Almudéver Campo Laura , Camaño Puig Ramón E.
Published: June 2022

Introducción: El desconocimiento etiológico de la gripe de 1918 sumado a la alta mortalidad que ocasionó, propició la aparición de multitud de fármacos y productos sanitarios para atajarla. Objetivo: Analizar los anuncios que se publicaron en la prensa española durante la epidemia de gripe de 1918. Metodología: Se ha realizado una selección de los anuncios que contienen el concepto ‘gripe’ en los periódicos de la hemeroteca digital de la Biblioteca Nacional de España, entre el 1 de enero de 1918 y el 31 de diciembre de 1920. Resultados: Se produjo un aumento en la frecuencia de publicación de los anuncios, los cuales se caracterizaron por la descripción del producto a ofertar y su validez frente a la epidemia de gripe. Conclusiones: Se observa la gran cobertura publicitaria que los periódicos otorgaron a la epidemia de gripe de 1918 y el gran número de anuncios publicitarios que surgieron para curar la enfermedad, lo que produjo un enorme impacto en la sociedad española.
Kinship, inter- and intraethnic social networks and refugees' division of housework
Authors: Kosyakova Yuliya , Kulic Nevena
Published: June 2022

Objective: This article investigates the role of social connections - kin proximity, premigration friends, and exposure to intra- and interethnic contacts in the host country - in the division of routine housework in refugee couples in Germany.
Background: Although social connections are established as an influential factor in the economic and societal integration of newcomers, the role of such connections for the household division of labor among immigrant couples is less understood.
Method: Pooled OLS and fixed-effect models were applied to four waves of the longitudinal IAB-BAMF-SOEP Survey of Refugees (2016-2019) to study coupled refugees of working age (1,045 couples, 2,699 couple-years).
Results: We find that social connections are significant to the gendered division of routine housework among refugee couples. In particular, networks consisting of new inter- and intraethnic contacts are more influential than those consisting of kins and premigration friends. Moreover, it appears that the kin and new coethnic contacts of the husband are negatively related to their involvement in housework in absolute hours and relative to their wives. Husbands' new contacts with Germans are positively related to their involvement in routine housework. In turn, wives’ contacts with Germans are not associated with a more egalitarian division of housework.
Conclusion: Social networks may provide useful explanations for immigrants' domestic behavior, and they should be considered in setting up new policies that guide their integration.
MENGEMBANGKAN MOTORIK HALUS MENGGUNAKAN MODEL PICTURE AND PICTURE, DIRECT INSTRUCTION DAN PEMBERIAN TUGAS PADA KELOMPOK B3
Authors: Nisa Hizratun , Jamain Ririanti Rachmayanie
Published: June 2022

Permasalahan dalam penelitian ini adalah perkembangan motorik halus anak dalam kegiatan melipat masih belum berkembang. Upaya dalam menyelesaikan masalah tersebut melalui pembelajaran menggunakan model picture and picture, direct instruction dan pemberian tugas. Tujuan penelitian ini untuk mengetahui aktivitas guru, aktivitas anak dan hasil capaian perkembangan motorik halus anak. Pendekatan penelitian menggunakan pendekatan kualitatif dengan jenis penelitian adalah Penelitian Tindakan Kelas yang dilaksanakan pada anak kelompok B3 RA Datu Abulung Banjarmasin dengan jumlah anak sebanyak 5 orang. Hasil penelitian ini menunjukkan bahwa pembelajaran dengan model Padi dapat mengembangkan motorik halus anak pada kategori Berkembang Sangat Baik dengan persentase 100%.
MENGEMBANGKAN MOTORIK HALUS MENEMPEL MENGGUNAKAN MODEL EXPLICIT INSTRUCTION, METODE DRILL DAN TEKNIK MOZAIK KELOMPOK B
Authors: Norlatifah Norlatifah , Novitawati Novitawati
Published: June 2022

Penelitian ini dilatarbelakangi pada rendahnya perkembangan aspek motorik halus dalam menempel dengan tepat. Dikarenakan pembelajaran disekolah lebih sering menggambar dan mewarna, media yang digunakan kurang bervariasi, kurangnya semangat belajar anak, dan pembelajaran yang bersifat satu arah yang menyebabkan anak kurang terlibat secara langsung. Penelitian bertujuan guna meningkatkan aktivitas guru, aktivitas anak dan hasil pengembangan aspek motorik halus dalam pembelajaran menempel dengan tepat. Penelitian ini dilakukan dengan pendekatan penelitian kualitatif dengan jenis yang Penelitian Tindakan Kelas (PTK) yang dilaksanakan dalam 3 kali pertemuan. Objek dalam penelitian ini adalah anak kelompok B TK Melati Babirik kab. Hulu Sungai Utara yang berjumlah 6 orang anak. Hasil penelitian menunjukkan aktivitas guru memperoleh skor 27 (sangat baik), aktivitas anak memperoleh persentasi 100% (sangat aktif), dan hasil perkembangan anak memperoleh persentasi 100% dengan kriteria BSB.
CREATING RELIGIOUS CHARACTER AND DISCIPLINE THROUGH TAHFIDZ QUR'AN ACTIVITIES
Authors: Amelia Rizka
Published: June 2022

This research aims 1)Describe and explain in depth the concept of religious character formation and discipline through tahfidz Al-Qur'an activities in Kindergarten Kindergarten Al Hamid and TK Blossom Banjarmasin, 2) Describe and explain in depth the process of religious character and discipline through tahfidz Al-Qur'an activities Qur'an in Kindergartens TK Al Hamid and TK Blossom Banjarmasin, 3) Describe and explain in depth the religious character of alumni as a result of the method of forming religious character and discipline through tahfidz Al-Qur'an activities in Kindergarten of Al Hamid Kindergarten and Blossom Kindergarten Banjarmasin. The method used is qualitative. The results of the study obtained from interview and observational data showed that the activity of tahfidz Al-Qur'an was the initial strategy applied by the teacher in instilling religious and disciplined characters in their students. The program for reciting the Koran, praying Duha, praying and praying Dzuhur together.
DEVELOPING THE SCHOOL PARTNERSHIP MODEL WITH THE COMMUNITY
Authors: Rahmina Rahmina
Published: June 2022

The increase in population and economic needs in Banjar District, to be precise, the Peat District, has an effect on the increasing land needs for community activities. This is one of the driving forces for the conversion of agricultural land to non-agricultural land. On the other hand, the increasing need for food has made the government have to establish a policy to protect food agricultural land so that it is not converted. Efforts to control the change in the function of food land need to look at the factors that affect land use change in each region. Thus, the established program is more effective because it is able to answer the problems faced by the community, especially land owners. This study aims to determine the factors of land change and the impact of the change in function from agricultural to non-agricultural land for farmers. This research method uses qualitative methods through collecting data through the stages of observation, data reduction, data presentation, and drawing conclusions. As well as interviews. The results of the study in the factor of land conversion for farmers due to government policies and economic pressure that occurred in family life. The impact of land use change in the Peat District that is felt by the farmers is the narrow land for cultivation and flooding that cannot be calculated when the water rises
SOCIAL CAPITAL CONTRIBUTION IN THE CONTINUOUS STRATEGY OF JENGKOL MANUFACTURERS IN THE COVID-19 PANDEMIC
Authors: Rusmaniah Rusmaniah , Nugroho Dedy Ari
Published: June 2022

The COVID-19 pandemic has an impact on the sector in Indonesia. One of them occurred in jengkol producers in Pingaran village, Banjar Regency, which decreased by 50%. This study aims to describe the social capital that exists in the lives of jengkol producers and the contribution of social capital in the jengkol business continuity strategy during the covid-19 pandemic. That approach is qualitative. Collecting data through in-depth interviews, observation, and documentation. Data analysis went through the reduction, presentation, and conclusion stages and was finally verified. The benefit of this research is that it can determine the contribution of social capital and strategies in maintaining a business amid the covid-19 pandemic. The results of the study explain the elements of social capital that are formed, namely networks, norms, and trust. The most dominant element of social capital in the jengkol business is the network element. The strategies carried out by jengkol producers in business continuity include good relations between fellow jengkol traders, using secret ingredients, expanding marketing networks, and using government funding as a solution for capital continuity.
Cherrapunjee: An Example of Human Impact on Environment
Authors: Sharma Sukanya
Published: June 2022

Palynological studies in Cherrapunjee located in Meghalaya, India have concluded that the modern grasslands of Cherrapunjee are the result of anthropogenic activity in the recent past leading to the deterioration of the primary dense forest. The forest humus was removed after extensive deforestation by human activity. Human presence in the area is indicated by Oryza Sativa, the common domesticated rice variety and Plantago lanceolata, which is a common weed of cultivated land. Like many other regions of the world, this human activity is thought to be agriculture, mainly shifting cultivation. But shifting cultivation is also practised in Garo Hills, Nagaland, and Arunachal Pradesh where pollen profiles of the recent past do not indicate the complete disappearance of the primary dense forest. In fact, indigenous shifting cultivators across Northeast India never uproot the large trees because the root foliage holds the soil. Within six months after the plot is abandoned, the primary forest bounces back to its original form.
This study hypothesises that human activity other than agriculture was responsible for the deterioration of the primary dense forest of Cherrapunjee. The study is based on the assumption that the whole process of erecting megaliths and iron smelting technology in the area resulted in the complete destruction of the primary forest on the flat top surface of the plateau where Cherrapunjee is located.
Targeted Anti-mitochondrial Therapy: The Future of Oncology
Authors: Taghizadeh-Hesary Farzad , Behnam Babak , Akbari Hassan , Bahadori Moslem
Published: June 2022

Like living organisms, cancer cells require energy to survive and interact with their environment. Mitochondria are the main organelles for energy production and cellular metabolism. Recently, investigators demonstrated that cancer cells can hijack mitochondria from immune cells. This behavior sheds light on a pivotal piece in the cancer puzzle, the ‘dependence’ on the normal cells. This article illustrates the benefits of new, functional mitochondria for cancer cells that urge them to hijack mitochondria. It describes how functional mitochondria help cancer cells’ survival in the harsh tumor microenvironment, immune evasion, progression, and treatment resistance. Recent evidence has put forward the pivotal role of mitochondria in cancer stem cells’ metabolism. This theory highlights the mitochondria in cancer biology and explains how targeted anti-mitochondrial treatments can improve oncological outcomes.
The Mechanism of Methylmercury Permeation Through the Blood-Brain Barrier using Caenorhabditis Elegans
Authors: Jaffery Zehra
Published: June 2022

Methylmercury is a neurotoxin present in fish tissues that permeates the blood-brain barrier after consumption. Previous research has shown that methylmercury is harmful to neurons, causing pH alterations, oxidative stress, excitotoxicity, and parenchymal damage. Methylmercury is a known factor of neurological disorders including Alzheimer's and Parkinson's. The method by which methylmercury passes through the blood-brain barrier is largely unknown. According to preliminary studies, one way methylmercury crosses the blood-brain barrier is by creating a complex with L-Cysteine, which facilitates its passage by the LATs system through mimicking another amino acid existing in the body. The human blood-brain barrier was studied using C. elegans as a model organism. It was hypothesized that if methylmercury passes through the blood-brain barrier of C. elegans faster with L-Cysteine present than without L-Cysteine present, the methylmercury's adverse effects (death and locomotive difficulty) will occur sooner. Each of the four experimental groups contained one C. elegans: the control, the L-Cysteine group, the methylmercury group, and the methylmercury and L-Cysteine combination group. The effects of L-Cysteine and methylmercury on C. elegans were studied using three metrics: viability, locomotive disability, and time for locomotive effects to occur. The group that received both methylmercury and L-Cysteine had reduced viability rates and a decreased time for locomotive difficulty to develop, supporting the hypothesis. These findings suggest that L-Cysteine aids methylmercury permeation through the blood-brain barrier. Because the experiment indicates how methylmercury penetrates the blood-brain barrier, these results aid in finding a therapeutic solution to reverse methylmercury neurotoxicity in the brain. Additionally, this study further opens channels into potential therapeutic and preventative measures for dementia, improving morbidity and mortality in neurodegenerative diseases.
Chickpea Water and Chickpea Polyphenols Induce Apoptosis and Alleviate Cell Migration In Vitro in Human Colon Adenocarcinoma Cells
Authors: Bochenek Heidi , Francis Nidhish , Santhakumar Abishek B. , Blanchard Christopher L. , Chinkwo Kenneth A.
Published: June 2022

Chickpea is an essential legume, a staple food in many cultures and contains nutrients with potential health benefits. The chickpea water (CPW) leached out after cooking is usually discarded, which may potentially have significant anti-cancer and other health beneficial properties. This study compared the in-vitro bioactivity of CPW with chickpea polyphenol extract (CPPE) to evaluate its impact on pathways of colorectal cancer progression and development. Morphological observation by APOPercentage, cell viability detection using a cytotoxic assay and cell migration-scratch assay points to measure rate of metastasis were employed. Overall antioxidant activity of CPW and CPPE were measured using ABTS and DPPH free-radical assays. At 50 µg/mL concentration and above, both CPW and CPPE extracts significantly reduce cell viability in HT-29 colon cancer cell lines (p < 0.05). Moreover, a quantitative analysis of the extent of apoptosis demonstrated that at 250 and 500 μg/mL concentrations, both extracts induced significant apoptosis compared to the untreated control. Meanwhile, the cell migration scratch area decreases by 34.42% and 15.27% when treated with CPW and CPPE, respectively. In summary, CPW demonstrated comparable in vitro anti-cancer properties and antioxidant activity in colorectal cancer cells to CPPE. Further, in vivo studies are warranted to evaluate the physiological bioactivity of CPW and CPPE in targeting pathways of cancer development and progression
Determining the Severity of Open and Closed Cracks Using the Strain Energy Loss and the Hill-Climbing Method
Authors: Tufisi Cristian , Rusu Catalin V. , Gillich Nicoleta , Pop Marius Vasile , Hamat Codruta Oana , Sacarea Christian , Gillich Gilbert-Rainer
Published: June 2022

Evaluating the integrity of structures is an important issue in engineering applications. The use of vibration-based techniques has become a common approach to assessing cracks, which are the most often occurring damage in structural elements. When involving an inverse method, it is necessary to know the influence of the position and the geometry of the crack on the modal parameter changes. The geometry of the crack, both in size and shape, defines the damage severity (DS). In this study, we present a method (DS-SHC) used for estimating the DS for closed and open transverse cracks in beam-like structures by using the intact and damaged beam deflections under its weight and a Stochastic Hill Climbing (SHC) algorithm. After describing the procedure of applying DS-SHC, we calculate for a prismatic cantilever beam the severities for different crack types and depths. The results are tested by comparing the DS obtained with DS-SHC with those acquired from dynamic tests made using professional simulation software. We obtained a good fit between the severities determined in these two ways. Afterward, we performed laboratory experiments and find out that the severities obtained with the DS-SHC method can accurately predict the frequency changes due to the crack. Hence, these severities are a valuable tool for damage detection.
A High School Teaching/Learning Path on Electromagnetic Induction: A Case Study
Authors: Giliberti Marco , Stellato Marco , Cavinato Michela
Published: June 2022

We present here a five hours experimentation of a didactical path about the electromagnetic induction addressed to students of the last year of an Italian scientific high school and oriented to better understand the physical origin of the induced electromotive force. The expression of the induced electromotive force as the sum of the term linked to the time variation of the magnetic field and of the motional one has been obtained in a detailed way, still suitable for presentation at high school. Many examples have been proposed to the students in order to clarify the conceptual physical knots. The students’ responses to a 6-questions multiple choice questionnaire have been analyzed. It emerged that our approach is concretely feasible although we find the well-known difficulties in calculating flux and circulation of a vector field. Furthermore, it emerged that an integral approach to the problem masks the understanding of the nature of the forces acting locally on the charges. Hence our proposal of a “redefinition” of the induced electric field in terms of the magnetic vector potential is also presented.
The Dataharmonizer: a Tool for Faster Data Harmonization, Validation, Aggregation, and Analysis of Pathogen Genomics Contextual Information
Authors: Gill Ivan , Griffiths Emma , Dooley Damion , Cameron Rhiannon , Savić Kallesøe Sarah , John Nithu Sara , Sehar Anoosha , Gosal Gurinder , Alexander David , Chapel Madison , Croxen Matthew , Delisle Benjamin , Di Tullio Rachelle , Gaston Daniel , Duggan Ana , Guthrie Jennifer , Horsman Mark , Joshi Esha , Kearney Levon , Knox Natalie , Lau Lynette , LeBlanc Jason , Li Vincent , Lyons Pierre , MacKenzie Keith , McArthur Andrew , Panousis Emilie , Palmer John , Prystajecky Natalie , Smith Kerri , Tanner Jennifer , Townend Christopher , Tyler Andrea , Van Domselaar Gary , Hsiao William
Published: June 2022

Pathogen genomics is a critical tool for public health surveillance, infection control, outbreak investigations, as well as research. In order to make use of pathogen genomics data, it must be interpreted using contextual data (metadata). Contextual data includes sample metadata, laboratory methods, patient demographics, clinical outcomes, and epidemiological information. However, the variability in how contextual information is captured by different authorities and how it is encoded in different databases poses challenges for data interpretation, integration, and its use/re-use. The DataHarmonizer is a template-driven spreadsheet application for harmonizing, validating, and transforming genomics contextual data into submission-ready formats for public or private repositories. The tool’s web browser-based JavaScript environment enables validation and its offline functionality and local installation increases data security. The DataHarmonizer was developed to address the data sharing needs that arose during the COVID-19 pandemic, and was used by members of the Canadian COVID Genomics Network (CanCOGeN) to harmonize SARS-CoV-2 contextual data for national surveillance and for public repository submission.In order to support coordination of international surveillance efforts, we have partnered with the Public Health Alliance for Genomic Epidemiology to also provide a template conforming to its SARS-CoV-2 contextual data specification for use worldwide. Templates are also being developed for One Health and foodborne pathogens. Overall, the DataHarmonizer tool improves the effectiveness and fidelity of contextual data capture as well as its subsequent usability. Harmonization of contextual information across authorities, platforms and systems globally improves interoperability and reusability of data for concerted public health and research initiatives to fight the current pandemic and future public health emergencies. While initially developed for the COVID-19 pandemic, its expansion to other data management applications and pathogens is already underway.
Opportunities and Challenges in the Lake Turkana Fishery: Building a Sustainable Fisheries Sector
Authors: Keyombe James Last , Obuya Julia , Owoko Winnie , Namwaya David , Katiwa Elizabeth
Published: June 2022

Turkana County's fisheries sector, which is entirely dependent on Lake Turkana, is vital to the county's economy. The Fisheries Sector in the County supports 1,500 households directly and 1,100 households indirectly. Despite its economic and social importance, the sector faces numerous challenges such as high post-harvest fish losses, uncoordinated development approaches, over-exploitation of some lake areas and weak links between research, management, and other sector players. Furthermore, since the start of devolution in 2013, the sector has been operating without an overall policy and legal framework. The primary goal of the study was to identify important challenges in the management of the fisheries sector in Turkana County that would lead the successful and coordinated growth of the fisheries industry. To capture their perspectives on the problems and potential in the usage of Lake Turkana's fisheries resources, semi-structured questionnaires and Key Informants interviews were used to collect primary data from the sector's fisheries actors. A total of 60 people were interviewed, and their responses were recorded in the Kobo Collect toolbox for later analysis. Secondary data was also gathered from numerous national policy declarations, guidelines, and legislation that have been used to manage Lake Turkana's fishery resources. The findings indicate that a policy directing the exploitation and development of fisheries is required in order to fully realize the potential of fisheries and aquaculture in the County. The development of the policy will lay a solid foundation for the creation of a legal framework to strengthen the sector in Turkana County, which is a necessary step toward achieving sustainable development and management of fisheries in accordance with national, regional, and international frameworks. By leveraging the role of the County Directorate of Fisheries and Beach Management Units in the sectors' monitoring, management, and development, the policy will also promote effective coordination of stakeholders at all levels.
PENGARUH PEMBERIAN PUPUK ECO FARMING dan VERMIKOMPOS PADA PERTUMBUHAN CABAI MERAH (Capsicum annum L.)
Authors: Khairani Siti , Novianty Lily , Novianty Lily , Sembiring Juhardi , Sembiring Juhardi , Mukhlisin Denny , Mukhlisin Denny
Published: June 2022

Eco farming fertilizers and vermicompost are very important in plant cultivation because they can affect plant growth and reduce the use of synthetic fertilizers. Various ways continue to be developed in order to create quality organic fertilizers so that red chili (Capsicum annum L.) plants can grow well. This study aims to determine the effect of giving eco farming fertilizers and vermicompost on red chili plant growth, knowing the right dose of eco farming fertilizer on red chili plants, and knowing the interaction between eco farming fertilizers and vermicompost on red chili plant growth. The experimental design used was factorial RAK with two factors, namely the provision of vermicompost (V) consisting of 3 levels, namely V0 (0g/polybag), V1 (25g/polybag), and V2 (50g/polybag). Eco farming fertilizer consists of 3 levels, namely E0 (0ml mixed fertilizer/polybag), E1 (25ml mixed starter/polybag), and E2 (50ml mixed starter/polybag). Parameters observed were plant height (cm), stem diameter (mm) and root volume (ml). The results showed that the application of eco farming fertilizer on the growth of red chili (Capsicum annum L.) gave no significant effect on plant parameters (cm), stem diameter (mm) and root volume (ml). Meanwhile, the application of vermicompost on the growth of red chili (Capsicum annum L.) had no significant effect on the parameters of plant height (cm), stem diameter (mm) and root volume (ml). The best treatment was giving a dose of 50% vermicompost and 50 ml eco farming fertilizer. The interaction of the application of eco farming fertilizer and vermicompost showed no significant effect on all observed parameters.
Increasing Electric Bicycle Performance using Lithium Ferro Phospate Batteries with a Battery Management System
Authors: Suci Windhu Griyasti
Published: June 2022

The depletion of fossil fuel sources and the increasing environmental pollution caused by the burning of motor vehicle fuels are major problems worldwide that need to be solved. One of the promising solutions to overcome energy security and environmental pollution is the use of electric vehicles. E-bikes are one of the most popular electric vehicles because of their many benefits. A valve-regulated lead acid battery (VRLA) is now the most common energy source for electric vehicles. It is heavy and unsafe for the user due to its poor energy density. Lithium ion batteries may be a feasible solution. One type of Li-ion battery that is environmentally friendly is lithium ferro phosphate (LFP). The potential that exists encourages researchers to conduct research and compare the performance of VRLA batteries with LFP batteries. The data retrieval method is carried out using the Arduino data logger application and is equipped with a microcontroller to read current and voltage. The test results prove that the LFP battery has good voltage stability. The distance that can be traveled is quite long, which is up to 50.16 km, because it is supported by a large capacity. On the other hand, VRLA can only travel 37.83 kilometers. Furthermore, the energy density of LFP batteries is great. The VRLA battery has a low energy density of 38.7 Wh/kg, whereas the LFP battery has a higher energy density of 117 Wh/kg, making it lighter and safer for users.
La significancia estadística y la relevancia clínica en la odontología
Authors: Arriola-Guillén Luis Ernesto
Published: June 2022

Los odontólogos se enfrentan a decisiones clínicas muy importantes en su práctica dental diaria, por lo que permanentemente requieren de sustento científico que las respalde, claramente en beneficio de los pacientes. Sin embargo, algunas veces, en la literatura científica se encuentran resultados con diferencias estadísticamente significativas, lo que ocasiona que los clínicos deban optar por alguna alternativa de tratamiento en particular; pero resulta que podría tratarse de una diferencia significativa que clínicamente no sea relevante, y esto hace que surja en el profesional la interrogante de qué decisión tomar.
Células troncales cancerígenas en carcinoma oral de células escamosas. Revisión de la literatura
Authors: Rodríguez-Vargas Mariana Paulina , Alvarado-Garnica Hugo , Gutiérrez-Verdín Luis David , Villanueva-Sánchez Francisco Germán , García-Contreras René
Published: June 2022

Objetivo: Describir, mediante una revisión de la literatura, el carcinoma oral de células escamosas, la presencia de células troncales cancerígenas, su asociación con el curso de la enfermedad y las aplicaciones terapéuticas. Método: Se realizó una búsqueda en la base de datos PubMed introduciendo el siguiente algoritmo: (((neoplastic stem cells [MeSH Terms]) OR (Cancer stem cells [Text Word])) AND (Squamous Cell Carcinoma of Head and Neck [MeSH Terms])) AND (Oral squamous cell carcinoma [Text Word]), para hallar artículos en idioma inglés publicados entre los años 2012 y 2022. Se utilizó el diagrama PRISMA para la identificación y elección de los artículos. Resultados: Se obtuvo un resultado de 49 artículos, de los cuales se eligieron 27 según su título y resumen, y su asociación con el tema. Se incluyeron 8 artículos adicionales sugeridos por su relación con la información previamente buscada, con lo que sumaron un total de 35 artículos evaluados. Se encontró que las células tumorales en el carcinoma oral de células escamosas son heterogéneas, pues incluyen células troncales cancerígenas, las cuales poseen características de células troncales, así como de células neoplásicas. Se las ha asociado con la progresión de la enfermedad, la recurrencia y la metástasis, y se ha considerado que son un mecanismo clave en el fallo en la terapia. Conclusiones: Se han identificado células troncales en carcinomas orales de células escamosas, las cuales han mostrado la expresión de marcadores, los cuales aportaron en su identificación y se han implicado en el comportamiento de las células cancerosas. Se han propuesto y desarrollado nuevas medidas terapéuticas dirigidas a la eliminación de las células troncales cancerígenas.
Uso de herramientas de imagenología actual para el estudio del mixoma odontogénico. Una revisión de la literatura
Authors: Vidales-Miranda Rocío , Fiori-Chíncaro Gustavo Adolfo , Agudelo-Botero Ana María , Llaguno-Rubio Jhoana Mercedes
Published: June 2022

En la actualidad, el mixoma odontogénico (MO) se clasifica como tumor benigno de origen ectomesenquimal, que se observa entre la segunda y cuarta década de edad, con predilección en mujeres y predominio en región mandibular, compuesto por células redondeadas y angulares incrustadas en un estroma mixoide abundante, de comportamiento biológico agresivo, con la característica de ser localmente infiltrativo; las células tumorales llegan a diseminarse en el espaciointratrabecular más allá del límite óseo. Difícilmente se llega a determinar el borde del tumor, incluso sin continuidad cortical presentando contacto directo con el tejido blando circundante. El aspecto puede ser unilocular (lesiones pequeñas), o comúnmente la imagen típica es la de una lesión destructiva de bordes mal definidos con patrón de crecimiento multilocular, para ello el uso de imágenes médicas avanzadas como la tomografía computarizada de haz cónico (TCHC), latomografía computarizada (TC) y la resonancia magnética (RM) son de utilidad para establecer un diagnóstico adecuado con la capacidad de señalar las características del MO con precisión y perspectiva tridimensional. Esta revisión presenta un análisis sistematizado sobre los tipos de herramientas imagenológicas que son utilizados actualmente para el estudio del MO.