bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of inhibition of the renin-angiotensin system on early cardiac and renal abnormalities in Sprague Dawley rats fed short-term high fructose plus high salt diet
Authors: Siddiqui Sharif Hasan , Pitpitan Rebekah , Boychev Boycho , Komnenov Dragana , Rossi Noreen F.
Published: August 2024

Introduction

The combination of a high fructose and high salt diet typical of western diet induces high blood pressure, aortic stiffening, left ventricular (LV) diastolic dysfunction and impaired renal function in rodents. Despite an activated renin-angiotensin system (RAS) in rats fed high fructose and high salt, acute inhibition of the RAS pathway does not improve cardiac and vascular parameters. It may well be that longer term treatment is required to permit remodeling and improve cardiovascular function. Thus, we hypothesized that chronic RAS inhibition fructose+high salt-fed rats to restore blood pressure (BP) to levels similar to glucose plus normal salt-fed controls will improve cardiorenal function and histopathology.

Methods

Male and female Sprague Dawley rats monitored by hemodynamic telemetry were fed 0.4% NaCl chow during baseline, then changed to chow containing either 20% glucose+0.4% NaCl (G) or 20% fructose+4% NaCl (F) and treated with vehicle, enalapril (Enal, 4 mg/kg/d) or losartan (Los, 8 mg/kg/d) by osmotic minipump for 25–26 days.

Results

BP was elevated in the fructose+high salt groups of both sexes (P < 0.05) and restored to control levels by Enal or Los. Pulse wave velocity (PWV) was lower in female F+Los rats and cardiac output higher in female F+Enal rats. GFR was not changed by diet or treatment. Fructose+high salt groups of both sexes displayed higher albuminuria that was decreased by Enal in male rats. Cardiac fibrosis and mesangial hypercellularity were greater in fructose+high salt-fed rats of both sexes and improved with either Los or Enal.

Discussion

Thus, inhibition of the RAS improves early changes in cardiac and renal histopathology in both sexes and albuminuria in male rats fed high fructose and high salt diet. Functional improvements in cardiorenal parameters may require longer treatment.
Estimated incidence of disruptions to event-free survival from non-metastatic cancers in New South Wales, Australia - a population-wide epidemiological study of linked cancer registry and treatment data
Authors: Morrell Stephen , Roder David , Currow David , Engel Alexander , Hovey Elizabeth , Lewis Craig R. , Liauw Winston , Martin Jarad M. , Patel Manish , Thompson Stephen R. , O’Brien Tracey
Published: August 2024

Introduction

Population cancer registries record primary cancer incidence, mortality and survival for whole populations, but not more timely outcomes such as cancer recurrence, secondary cancers or other complications that disrupt event-free survival. Nonetheless, indirect evidence may be inferred from treatment data to provide indicators of recurrence and like events, which can facilitate earlier assessment of care outcomes. The present study aims to infer such evidence by applying algorithms to linked cancer registry and treatment data obtained from hospitals and universal health insurance claims applicable to the New South Wales (NSW) population of Australia.

Materials and methods

Primary invasive cancers from the NSW Cancer Registry (NSWCR), diagnosed in 2001–2018 with localized or regionalized summary stage, were linked to treatment data for five common Australian cancers: breast, colon/rectum, lung, prostate, and skin (melanomas). Clinicians specializing in each cancer type provided guidance on expected treatment pathways and departures to indicate remission and subsequent recurrence or other disruptive events. A sample survey of patients and clinicians served to test initial population-wide results. Following consequent refinement of the algorithms, estimates of recurrence and like events were generated. Their plausibility was assessed by their correspondence with expected outcomes by tumor type and summary stage at diagnosis and by their associations with cancer survival.

Results

Kaplan-Meier product limit estimates indicated that 5–year cumulative probabilities of recurrence and other disruptive events were lower, and median times to these events longer, for those staged as localized rather than regionalized. For localized and regionalized cancers respectively, these were: breast - 7% (866 days) and 34% (570 days); colon/rectum - 15% (732 days) and 25% (641 days); lung - 46% (552 days) and 66% (404 days); melanoma - 11% (893 days) and 38% (611 days); and prostate - 14% (742 days) and 39% (478 days). Cases with markers for these events had poorer longer-term survival.

Conclusions

These population-wide estimates of recurrence and like events are approximations only. Absent more direct measures, they nonetheless may inform service planning by indicating population or treatment sub-groups at increased risk of recurrence and like events sooner than waiting for deaths to occur.
Case report: A case of giant breast skin warts caused by HPV infection
Authors: Wang Chaohui , Zhao Yuyang , Sun Zhenhua , Li Mingjun
Published: August 2024

GCA, also known as Buschke-Lowenstein tumor, is a rare sexually transmitted disease associated with HPV types 6 and 111. These warts are considered histologically benign, but there is a risk of localized invasion and development of malignancy. This malignant transformation occurs most often in the perianal and vulvar areas, and involvement of other sites is relatively rare2. In this case, we report a rare case of a giant wart originating from breast skin infected with HPV and progressing to cutaneous squamous cell carcinoma.
A protocol for obtaining upper and lower extremity joints’ range of motion in children using three-dimensional motion analysis system
Authors: Afifi Mohamed , Abdulazeez Muhammad Uba , Aminian Kamiar , Stylianides Georgios Antoniou , Abdullah Kassim Abdulrahman
Published: August 2024

Three-dimensional (3D) motion analysis (MA) techniques are progressively being used in biomechanics research and for clinical applications to assess the risk of injuries. A marker-based 3D MA protocol has been developed to measure the upper and lower extremity (UE and LE) joints’ active and passive ranges of motion (AROM and PROM) in children. The joints that were included in this protocol are shoulder, elbow, wrist, hip, knee and ankle. The anatomical joint coordinate systems (JCS) have been defined for the upper and lower extremities to standardize reporting. A marker placement model was defined according to the International Society of Biomechanics (ISB) recommendations and used to develop the protocol. The proposed movements will be captured and analyzed using the Motion Analysis Corporations 3D MA system integrated with Cortex software. The movements adopted in this study have been selected from various sources to incorporate all joint rotations while ensuring the isolation of each joint motion during the movements. It is recommended that future studies utilize this protocol to draw a relationship between the joints’ range of motion (ROM) and the adjacent segments characteristics, i.e., segment length, joint stiffness, etc.
Short-term HIIT impacts HDL function differently in lean, obese, and diabetic subjects
Authors: Zhu Lin , An Julia , Luu Thao , Reyna Sara M. , Tantiwong Puntip , Sriwijitkamol Apiradee , Musi Nicolas , Stafford John M.
Published: August 2024

Introduction

High density lipoproteins (HDL) exert cardiovascular protection in part through their antioxidant capacity and cholesterol efflux function. Effects of exercise training on HDL function are yet to be well established, while impact on triacylglycerol (TG)-lowering has been often reported. We previously showed that a short-term high-intensity interval training (HIIT) program improves insulin sensitivity but does not inhibit inflammatory pathways in immune cells in insulin-resistant subjects. The purpose of this study is to evaluate HDL function along with changes of lipoproteins after the short-term HIIT program in lean, obese nondiabetic, and obese type 2 diabetic (T2DM) subjects.

Methods

All individuals underwent a supervised 15-day program of alternative HIIT for 40 minutes per day. VO2peak was determined before and after this training program. A pre-training fasting blood sample was collected, and the post-training fasting blood sample collection was performed 36 hours after the last exercise session.

Results

Blood lipid profile and HDL function were analyzed before and after the HIIT program. Along with improved blood lipid profiles in obese and T2DM subjects, the HIIT program affected circulating apolipoprotein amounts differently. The HIIT program increased HDL-cholesterol levels and improved the cholesterol efflux capacity only in lean subjects. Furthermore, the HIIT program improved the antioxidant capacity of HDL in all subjects. Data from multiple logistic regression analysis showed that changes in HDL antioxidant capacity were inversely associated with changes in atherogenic lipids and changes in HDL-TG content.

Discussion

We show that a short-term HIIT program improves aspects of HDL function depending on metabolic contexts, which correlates with improvements in blood lipid profile. Our results demonstrate that TG content in HDL particles may play a negative role in the anti-atherogenic function of HDL.
HcZnT2 is a highly mycorrhiza-induced zinc transporter from Hebeloma cylindrosporum in association with pine
Authors: Ho-Plágaro Tania , Usman Muhammad , Swinnen Janne , Ruytinx Joske , Gosti Françoise , Gaillard Isabelle , Zimmermann Sabine D.
Published: August 2024

Zinc (Zn) shortage is a common micronutrient deficiency affecting plants worldwide, while Zn toxicity may occur when this metal is in excess. Ectomycorrhizal (ECM) fungi are known to be able to modulate the transfer of macro- and microelements, among them Zn, to the plant. However, the underlying mechanisms are not well understood. We identified the HcZnT2 gene from the ECM fungus Hebeloma cylindrosporum, encoding a member of the Cation Diffusion Facilitator (CDF) family including Zn transporters, and analyzed its transcriptional regulation, the transport function by yeast complementation experiments, and its subcellular localization using a GFP fusion protein in yeast. HcZnT2 is highly induced during mycorrhization of Pinus pinaster, and upregulated in presence of the host plant root even without any direct contact. However, HcZnT2 is repressed by Zn excess conditions. By functional expression in yeast, our results strongly support the ability of HcZnT2 to transport Zn and, to a lesser extent, manganese. HcZnT2 localization was associated with the endoplasmic reticulum of yeast. Mycorrhizal gene activation at low external Zn suggests that the Zn transporter HcZnT2 might be important for the early establishment of the ECM symbiosis during Zn deficiency, rather than under Zn excess. HcZnT2 arises as an extremely remarkable candidate playing a key role in Zn homeostasis and regulation in ectomycorrhiza.
Cariprazine and clozapine combination for the treatment of psychosis in a young, female patient with schizophrenia: a case report
Authors: Dmuhovskis Anzejs , Taube Maris
Published: August 2024

The task of a psychiatrist is to select the most appropriate medication or combination of drugs to treat the symptoms of schizophrenia while minimizing the risk of side effects and ensuring the patient achieves the highest level of functioning possible. This is a challenging task as the action of each drug or group of drugs is different. The efficacy of cariprazine, which affects D3 receptors as a D3/D2 receptor partial agonist, has been extensively studied and is one of the first medication choices by practicing psychiatrists when treating patients with negative symptomatology. In this clinical case, we demonstrate the effective and safe treatment of a patient’s positive and affective symptoms using a combination of cariprazine, clozapine, and venlafaxine.
The impact of attitude toward COVID-19 vaccine on intention to receive influenza vaccination: a multi-group comparison based on the influence of presumed influence model and spillover effects
Authors: Zhang Yun , Yi Hongfa
Published: August 2024

Introduction

Influenza vaccination is one of the most important strategies for preventing influenza. However, the influenza vaccination rate in China remains low. During the COVID-19 pandemic, people held different attitudes toward the COVID-19 vaccine. In the post-pandemic era, do the varying attitudes toward the COVID-19 vaccine affect the intention to receive influenza vaccination?

Methods

Based on the influence of presumed influence (IPI) model and spillover effects, this study employed structural equation modeling for multi-group comparison to analyze questionnaires from 613 participants, using instruments such as the Perceived Media Influence on Others Scale (PMIO), the Susceptibility to Influenza Scale (SI), and the Attitude toward Influenza Vaccine Scale (AIV).

Results

The key findings are as follows: (1) Information exposure to the influenza vaccine significantly influences perceived media influence on others. (2) Perceived media influence on others does not directly impact the intention to receive influenza vaccination but rather affects it through attitude toward the influenza vaccine. (3) Moreover, multi-group analyses revealed differences in the IPI model among audiences with different attitudes toward the COVID-19 vaccine. These differences demonstrated that prior attitudes toward the COVID-19 vaccine can influence attitudes toward similar influenza vaccines, thus demonstrating the existence of spillover effects.

Conclusion

Attitude toward the COVID-19 vaccine can influence the intention to receive the influenza vaccination. Those with a negative attitude toward the COVID-19 vaccine are significantly influenced by susceptibility to influenza. Perceived media influence affects the intention to receive the influenza vaccination among those with a positive attitude toward the COVID-19 vaccine.
Barriers to care for musculoskeletal sarcoma patients: a public health perspective
Authors: Syros Alina , Baron Max C. , Adalbert Jenna , Remer Hallie B. , Heng Marilyn , Crawford Brooke
Published: August 2024

Introduction

This study seeks to investigate the barriers to care that exist for patients presenting with sarcomas of musculoskeletal origin. Understanding the roots of delays in care for patients with musculoskeletal sarcoma is particularly important given the necessity of prompt treatment for oncologic diagnoses. Investigators reviewed relevant studies of publications reporting barriers to care in patients undergoing diagnosis and treatment of musculoskeletal tumors.

Methods

A comprehensive literature search was conducted using Scopus, Embase, Web of Science, and PubMed-MEDLINE. Twenty publications were analyzed, including a total of 114,056 patients.

Results

Four barrier subtypes were identified: Socioeconomic Status, Geographic Location, Healthcare Quality, Sociocultural Factors. Socioeconomic status included access to health insurance and income level. Geographic location included distance traveled by patients, access to referral centers, type of hospital system and resource-challenged environments. Healthcare quality included substandard imaging, access to healthcare resources, and healthcare utilization prior to diagnosis. Sociocultural factors included psychological states, nutrition, education and social support.

Conclusion

After identifying the most significant barriers in this study, we can target specific public health issues within our community that may reduce delays in care. The assessment of barriers to care is an important first step for improving the delivery of oncologic patient care to this patient population.
Suicide warning signs of self-identification in patients with mood disorders: a qualitative analysis based on safety planning
Authors: Zhang Honghui , Zhu Jiaxin , Niu Lu , Zeng Meng , Chen Tengwei , Chen Yuedong , Hou Xiaofei , Tao Haojuan , Ma Yarong , Lin Kangguang , Zhou Liang
Published: August 2024

Introduction

Warning signs serve as proximal indicators of suicide risk, making early recognition imperative for effective prevention strategies. This study aimed to explore self-identified suicide warning signs among Chinese patients with mood disorders based on safety planning framework.

Methods

Researchers collaborated with patients to develop a safety plan and compiled warning signs based on it. Word frequency and network analysis were conducted to identify key warning signs. Directed content analysis categorized these signs into cognitive, emotional, behavioral, or physiological themes according to the suicide mode theory. Additionally, we examined potential variations in reported warning signs among participants with different demographic characteristics, including age, gender, and history of suicide attempts.

Results

“Low mood” and “crying” emerged as prominent warning signs, with “social withdrawal” closely following. Patients commonly reported emotional themes during suicidal crises, often experiencing two to three themes simultaneously, primarily focusing on emotional, behavioral, and physiological themes. Males exhibited a higher proportion of concurrently reporting three sign themes compared to females (P < 0.05), while no difference was observed in warning signs among patients with other demographic traits.

Discussion

This study offers a nuanced understanding of warning signs among mood disorder patients in China. The findings underscore the necessity for comprehensive suicide risk management strategies, emphasizing interventions targeting emotional regulation and social support. These insights provide valuable information for enhancing suicide prevention and intervention efforts.
From trauma to resilience: advancing cultural responsiveness and equity in the Muskowekwan First Nation’s healing journey
Authors: Sasakamoose JoLee , Pete Shauneen , O’Soup Fred , Wolfe Tiffany
Published: August 2024

Introduction

The Muskowekwan First Nation (MFN) in Saskatchewan, Canada, epitomizes the enduring strength and cultural preservation of the Saulteaux people. This community faces the lasting effects of colonial trauma, especially the violence, abuse, and adversity experienced by students at the Muskowequan Indian Residential School (MIRS). Decades of abuse by institutional leaders caused generational trauma, contributing to current mental health and well-being challenges. This study highlights the community’s role in sharing experiences and shaping healing processes to develop the MFN Family Healing and Wellness Centre in response to urgent community concerns. It examines the integration of Justice, Diversity, Equity, and Inclusion (J-DEI) principles and cultural responsiveness in fostering community resilience and mental well-being.

Methods

Adopting a community-based participatory research framework, this study employs a mixed-methods approach, including community engagement sessions and surveys. Collaborating closely with the MFN leadership, it draws upon the specialized expertise of Author2 and Author1, leaders in Indigenous health and research. The research uses qualitative and quantitative data collection, emphasizing the importance of community input and leadership in shaping the research process and outcomes.

Results

Findings emphasize the community’s commitment to spiritual and cultural practices as vital healing components. Amidst the heightened awareness of the lingering effects of the MIRS within the MFN community, these insights informed the development of the Centre, ensuring it incorporates the community’s desires for culturally relevant healing practices. The grand opening of Phase I of the Centre in February 2023 emerged as a significant step forward, symbolizing a move towards holistic community health that honors resilience, holistic wellness, and cultural continuity.

Discussion

This case study contributes to the literature on integrated, culturally responsive healthcare models that address the needs of Indigenous peoples and communities. The study provides insights to guide the Centre’s future programs and services, ensuring they are culturally tailored and responsive to the community’s needs. By illustrating the potential for traditional wisdom and contemporary health practices to foster well-being, the case study advocates for holistic approaches to healing in Indigenous settings, offering a replicable framework for similar initiatives globally.
The impact of social activities on mental health among older adults in China
Authors: Gao Duanyang , Li Rui , Yang Yuying
Published: August 2024

Background

Understand the current situation of social activities among older adults and its impact on mental health, providing policy basis and intervention measures to improve the mental health of the older adult.

Method

Collect relevant data from 8,181 older adults aged ≥ 60 years old from the 2020 China Health and Retirement Longitudinal Study (CHARLS), constructing an analysis framework for social activities of older adults in China from three aspects: participation in social activities, number of social activities, frequency of social activities, and describe them, then analyzing the impact of social activities on their mental health using OLS and 2SLS regression models. This study also discusses the impact of eight social activities on the mental health of older adult people through subgroup.

Result

Among 8,181 older adults aged 60 and above, 3,808 participated in social activities (56.24%), average number of social activities is 0.71, and average frequency of social activities is 1.31 times. The average score of mental health level measured by CES-D is 15.24 points. Participate in social activities can reduce the depression level of the older adult (β = −0.352, 95%CI: −0.547~−0.158); the more social activities the older adult participate in, the lower the depression level of the older adult (β = −0.214, 95%CI: −0.313~−0.115); the higher the frequency of participating in social activities, the lower the depression level of the older adult (β = −0.133, 95%CI: −0.182~−0.083). In summary, social activities can improve the mental health level of the older adults in China. As for different types of social activities, visiting and socializing with friends, participating in club organization activities, playing mahjong, chess, cards, or going to community activity rooms and attending school or training courses can improve the mental health of the older adult.

Discussion

The social activities in three dimensions among older adults in China need to be further improved, and participating in social activities can help improve their mental health. The conclusion provides important policy implications for encouraging and supporting older adults to participate in various social activities, increasing the number and frequency of older adult social activities, then help improving the mental health level of older adults.
Please don't gayify!: an autoethnographic account of medicalised relationality for LGBTQI+ safe affirming medical health education and clinical practice
Authors: Vicars Mark , Deppeler Mickey
Published: August 2024

In this article, the authors, a cis-gender gay man and an Indigenous non-binary, two-spirit person, narrate their past encounters with health professionals and their experiences pursuing allied health care training as students. Taking an autoethnographic approach, the first author re-narrates how medical practitioners and students engage (or fail to engage) with the LGBTQIA+ community. They draw on gray documentation derived from an interaction with a consulting physician that highlighted a telling lack of knowledge about the LGBTQ+ community, including those with diverse sex characteristics and sexualities/manifesting as unconscious bias. This interaction provided the impetus to speak back to the experience of being reduced to a medical prognosis. The second author questions the hegemonic practices underpinning encounters with the medical model of response in tertiary education. Our remit in this paper is to question how adequately the specific needs of the LGBTQI+ population are being addressed by the medical model and to what extent aspiring clinicians understand how their actions can contribute to gender- and sexuality-based discrimination and stigmatization.
Scaling community-based aquaculture for enhanced nutrition and women’s empowerment: lessons from Odisha, India
Authors: Dubey Sourabh Kumar , Padiyar Arun , Chadag Vishnumurthy Mohan , Shenoy Neetha , Gaikwad Amar Bharat , Ratha Baishnaba Charan , Belton Ben
Published: August 2024

Introduction

Aquatic foods, particularly fish, are essential for addressing malnutrition, especially in vulnerable populations like children and women. In India, traditional aquaculture practices centered around carp species often overlooked the production of nutrient-rich small fish. To address this, nutrition-sensitive aquaculture approaches advocate for integrating species like mola carplet (Amblypharyngodon mola) rich in micronutrients, into existing systems. In Odisha, India, where poverty and food insecurity are prevalent, the government initiated a program to empower women through aquaculture, focusing on nutrition-sensitive carp-mola polyculture in community ponds through Women Self-Help Groups (WSHGs).

Methods

This study evaluates the effectiveness of this government program in enhancing income, household nutrition, and women’s empowerment. Data from field surveys conducted across all 30 districts of Odisha were analyzed to assess participation, capacity building, adoption of better management practices (BMPs), productivity of carp-mola polyculture, household fish consumption, and profitability.

Results and discussion

The study found widespread participation and adoption of BMPs among WSHGs, leading to increased productivity and income. Carp-mola polyculture systems showed higher productivity and consumption rates, contributing to improved nutrition among WSHGs and their communities. Despite challenges such as input costs and limited mola availability, WSHGs reported profitability from fish farming, with carp-mola polyculture systems yielding higher net income. Factors influencing productivity and profitability included water retention period, stocking density, feed application, and training. The program’s impact extended beyond economic benefits, encompassing environmental improvement, women’s empowerment, and enhanced nutrition outcomes.

The study highlights the success of the government program in promoting sustainable aquaculture practices and improving nutrition outcomes in Odisha. Continued support, capacity building, and collaboration among stakeholders are essential for scaling up nutrition-sensitive aquaculture interventions and ensuring long-term sustainability. Strengthening dissemination processes, addressing challenges, and further research on small indigenous fish production techniques are crucial for maximizing the program’s impact on food security and rural development.
Posterior Component Separation Technique—Original Transversus Abdominis Release (TAR) Technique
Authors: Gandhi Jignesh A. , Gajjar Aarsh P. , Shinde Pravin H. , Chaudhari Sadashiv
Published: August 2024

The history of ventral hernia repair techniques has seen substantial evolution, from primary suture repair to the introduction of mesh-based procedures, aiming to reduce recurrence rates. Notable advancements include the anterior and posterior component separation techniques. The Transversus Abdominis Release (TAR) technique, a refinement of the posterior approach, emerged to address challenges associated with complex ventral hernias. The TAR technique facilitates midline reconstruction, allowing large mesh placement while minimizing the need for subcutaneous dissection. Despite its benefits, TAR presents potential complications, emphasizing the necessity for meticulous preoperative assessment and training. The paper reviews the historical progression of hernia repairs, details the TAR technique, highlights indications, perioperative care strategies, surgical steps, postoperative management, technical challenges, and emphasizes the critical role of expertise in achieving successful outcomes in complex abdominal wall reconstruction.
Paszport psa, paszport covidowy, paszport do szczęścia: o nowych znaczeniach i użyciach wyrazu paszport
Authors: Zabawa Marcin
Published: August 2024

The paper aims at exploring the semantic innovation paszport ‘passport’ in Polish. The analysis involves a comparison of the traditional meanings of the word (taken from dictionaries of Polish: USJP, WSJP PWN, and WSJP PAN) and new meanings in texts excerpted from the Internet. Additionally, OED is consulted for the definitions of its English counterpart (passport). The study shows that the word paszport appears in new meanings and new collocations (usually triggered by English), and its development in Polish can be seen as multidirecƟ onal. Additionally, the author discusses a word from the normaƟtive point of view and concludes that it is often overused and its new uses are not always warranted and necessary.
Accessibility of Entrepreneurship Training Programs for Individuals with Disabilities: A Literature Review
Authors: Tiasakul Somrudee , Abdulzaher Ramy , Bazan Carlos
Published: August 2024

Entrepreneurial endeavours often begin with entrepreneurship training. Such trainings, however, remain largely inaccessible to Persons with Disabilities (PWDs), and thus, their entrepreneurial potential remains untapped. This comprehensive literature review examines the barriers to entrepreneurship education for PWDs and identifies strategies to overcome these challenges. The review follows the systematic approach of the PRISMA 2020 Statement, using five databases, including Scopus, JSTOR, ProQuest, DOAJ, and Google Scholar. A total of 2140 articles dating back 10 years were identified, screened, and evaluated, and 17 of them were selected and synthesized to inform the findings. The key findings highlight a spectrum of barriers, including inadequate access to quality education, difficulty in customizing entrepreneurship programs, issues related to both physical and digital access, financial barriers, and the influence of societal norms and self-perception. They also identify strategies to make entrepreneurship education more inclusive, such as applying universal design principles, tailoring education to individual needs, shifting towards active learner-centred methodologies, leveraging information technology, and fostering supportive communities. This review is a practical reference for institutions, organizations, and individuals endeavouring to enhance the inclusivity of entrepreneurship training programs. It also provides a theoretical framework for the already identified requirements of PWDs for entrepreneurship training and presents further opportunities through current limitations and suggestions for future research.
LettuceNet: A Novel Deep Learning Approach for Efficient Lettuce Localization and Counting
Authors: Ruan Aowei , Xu Mengyuan , Ban Songtao , Wei Shiwei , Tian Minglu , Yang Haoxuan , Hu Annan , Hu Dong , Li Linyi
Published: August 2024

Traditional lettuce counting relies heavily on manual labor, which is laborious and time-consuming. In this study, a simple and efficient method for localization and counting lettuce is proposed, based only on lettuce field images acquired by an unmanned aerial vehicle (UAV) equipped with an RGB camera. In this method, a new lettuce counting model based on the weak supervised deep learning (DL) approach is developed, called LettuceNet. The LettuceNet network adopts a more lightweight design that relies only on point-level labeled images to train and accurately predict the number and location information of high-density lettuce (i.e., clusters of lettuce with small planting spacing, high leaf overlap, and unclear boundaries between adjacent plants). The proposed LettuceNet is thoroughly assessed in terms of localization and counting accuracy, model efficiency, and generalizability using the Shanghai Academy of Agricultural Sciences-Lettuce (SAAS-L) and the Global Wheat Head Detection (GWHD) datasets. The results demonstrate that LettuceNet achieves superior counting accuracy, localization, and efficiency when employing the enhanced MobileNetV2 as the backbone network. Specifically, the counting accuracy metrics, including mean absolute error (MAE), root mean square error (RMSE), normalized root mean square error (nRMSE), and coefficient of determination (R2), reach 2.4486, 4.0247, 0.0276, and 0.9933, respectively, and the F-Score for localization accuracy is an impressive 0.9791. Moreover, the LettuceNet is compared with other existing widely used plant counting methods including Multi-Column Convolutional Neural Network (MCNN), Dilated Convolutional Neural Networks (CSRNets), Scale Aggregation Network (SANet), TasselNet Version 2 (TasselNetV2), and Focal Inverse Distance Transform Maps (FIDTM). The results indicate that our proposed LettuceNet performs the best among all evaluated merits, with 13.27% higher R2 and 72.83% lower nRMSE compared to the second most accurate SANet in terms of counting accuracy. In summary, the proposed LettuceNet has demonstrated great performance in the tasks of localization and counting of high-density lettuce, showing great potential for field application.
Spatial–Temporal Analysis of Impacts of Climate Variability on Maize Yield in Kenya
Authors: Ondiek Renish Awuor , Saber Mohamed , Abdel-Fattah Mohammed
Published: August 2024

This study examined the spatial temporal impacts of climate variability on maize yield in Kenya. The maize yield data were obtained from the Kenya Maize Yield Database while climatic variable data were obtained from the Climatic Research Unit gridded Time Series (CRU TS) with a spatial resolution of 0.5° × 0.5°. The non-parametric Mann–Kendall and Sen’s slope tests showed no trend in the data for maximum temperature, minimum temperature and precipitation. The spatial maps patterns highlight the rampancy of wetter areas in the Lake Victoria basin and Highlands East of Rift Valley compared to other regions. Additionally, there is a decreasing trend in the spatial distribution of precipitation in wetter areas and an increasing trend in maximum temperature in dry areas, albeit not statistically significant. Spearman’s rank correlation test showed a strong positive correlation between maize yield and the climatic parameters for the Lake Victoria basin, Highlands East of Rift Valley, Coastal Strip and North Western Regions. The findings suggest that climate variability has a significant impact on maize yield for four out of six climatological zones. We recommend adoption of policies and frameworks that will augment adaptive capacity and build resilience to climatic changes.
Parameter Optimization and Test for the Pulse-Type Gas Explosion Subsoiler
Authors: Xu Xiangdong , Jing Pengyu , Yao Quan , Chen Wenhui , Meng Hewei , Li Xia , Qi Jiangtao , Peng Huijie
Published: August 2024

To address the problem of large tractive resistance in traditional subsoiling methods, this paper designed a pulse-type gas explosion subsoiler, as well as an air-blown double-ended chisel type subsoiling shovel and a conduit. The mathematical equation of the influence of the structural parameters of the subsoiler on the groove profile is established. The EDEM 2022 software was used to simulate the subsoiling operation process. The soil disturbance law of the chisel subsoiler was analyzed by the change of soil particle velocity. The optimum value interval of quadratic regression orthogonal rotation combination test factors was determined by using the steepest climb test, with specific tillage resistance and filling power as evaluation indicators. Based on the Box–Behnken design test, a second-order regression model of response value and significance parameter was obtained, and an optimal combination was found by optimizing the significance parameter. The effects of subsoiling air pressure, pulse width and pulse interval on evaluation indicators were analyzed by the response surface method; the test results show that when the air pressure was 0.8 MPa, the pulse width was 0.17 s and the pulse interval was 0.12 s, and the specific tillage resistance was 0.4421 N/mm2 and the filling power was 18.5%; a comparative test between the pulse-type gas explosion subsoiler and a continuous gas explosion subsoiler was carried out, and the specific tillage resistance was reduced by 12.2% and the filling power was reduced by 10.5%; the comparative test shows that the pulse-type gas explosion subsoiler has smaller tractive resistance per unit area and smaller disturbance to soil. The research results provide a theoretical basis and reference for the optimization and improvement of gas explosion subsoilers.
Utilizing Principal Component Analysis to Assess the Effects of Complex Foliar Fertilizers Regarding Maize (Zea mays L.) Productivity
Authors: Crista Laura , Radulov Isidora , Crista Florin , Imbrea Florinel , Manea Dan Nicolae , Boldea Marius , Gergen Iosif , Ienciu Anișoara Aurelia , Lațo Alina
Published: August 2024

This study sought to determine the effects of foliar fertilization (FF) on both the quantity and quality of maize grains using principal component analysis (PCA). This chemometric approach enabled the selection of the best foliar treatment model for enhancing maize yield and quality. The results were analyzed via PCA, providing valuable insights into identifying the FF recipe with the greatest influence on maize grain production and quality. These field experiments were run during the time period 2020–2022 in the university’s experimental field. Seven experimental variants with three repetitions were tested, including a control group and various FF formulations labeled V1 through V7, each with different chemical compositions. FF applications were conducted during specific vegetative phases of the maize, respectively, in stages 15–16 BBCH (5–6 unfolded leaves) and 20–22 BBCH (10–12 unfolded leaves), with application rates varying from 2 to 6 Lha1 according to the product’s chemical properties. The application of FF treatments positively impacted both the production and quality of maize grains, as evidenced by specific quality indices such as moisture, protein, lipid, carbohydrate, fiber, and mineral content.
Below-Plant Mirrors Improve Serianthes Seedling Survival and Growth in Shade
Authors: Marler Thomas E.
Published: August 2024

Recruitment failures of Serianthes nelsonii are among the threats to this species’ recovery, yet adaptive management research to understand the causes of seedling mortality is lacking. Insufficient available light in the in situ forest floor is one factor that may be involved, and below-plant reflection of incident light may improve seedling survival. Mirrors were placed beneath S. nelsonii, Serianthes grandiflora, and Serianthes kanehirae seedlings in container nursery conditions and S. grandiflora seedlings in a closed-canopy forest to determine the influence of the additional reflected light on seedling survival and growth. Below-plant mirrors increased nursery seedling survival for S. nelsonii and S. kanehirae, with 75% combined survival without mirrors and 88% combined survival with mirrors. Below-plant mirrors increased stem height by 51% for the three species, with greater stem diameter and ending leaf number also occurring for plants with mirrors. Below-plant mirrors increased S. grandiflora seedling survival to 161% and longevity to 236% compared to plants without mirrors under forest cover. The plants receiving mirrors also increased by 175% in height, 60% in stem diameter, and 117% in leaf number compared to the plants without mirrors. These findings indicate that passive solar engineering by exploiting below-plant light reflection may be used as a Serianthes conservation protocol to improve seedling survival and growth under shaded conditions.
Satellite Solutions for Precision Viticulture: Enhancing Sustainability and Efficiency in Vineyard Management
Authors: Mucalo Ana , Matić Damir , Morić-Španić Antonio , Čagalj Marin
Published: August 2024

The priority problem in intensive viticulture is reducing pesticides, and fertilizers, and improving water-use efficiency. This is driven by global and EU regulatory efforts. This review, systematically examines 92 papers, focusing on progress in satellite solutions over time, and (pre)processing improvements of spatio-temporal and spectral resolution. The importance of the integration of satellites with ground truth data is highlighted. The results provide precise on-field adaptation strategies through the generation of prescription maps and variable rate application. This enhances sustainability and efficiency in vineyard management and reduces the environmental footprint of vineyard techniques. The effectiveness of different vegetation indices in capturing spatial and temporal variations in vine health, water content, chlorophyll levels, and overall vigor is discussed. The challenges in the use of satellite data in viticulture are addressed. Advanced satellite technologies provide detailed vineyard monitoring, offering insights into spatio-temporal variability, soil moisture, and vine health. These are crucial for optimizing water-use efficiency and targeted management practices. By integrating satellite data with ground-based measurements, viticulturists can enhance precision viticulture, reduce reliance on chemical interventions, and improve overall vineyard sustainability and productivity.
Changes in Soil Organic Matter Associated with Land Use of Arenosols from Southern Botswana
Authors: Kgathi Donald , Sekhwela Mogodisheng , Almendros Gonzalo
Published: August 2024

The effect of land use on sandy soils of southern Botswana was carried out by comparing the composition and properties of soil organic matter. Non-disturbed and disturbed soils were sampled from savanna ecosystems (Central District and Kweneng District). The biodegradability of organic matter was evaluated by incubation in the laboratory. Humic fractions were quantified and humic acids were analyzed by visible and infrared spectroscopy. The results indicate that continued disturbance, whether due to grazing or subsistence farming, has resulted in small yet significant changes in the concentration of available nutrients and organic matter in the soil. Nevertheless, substantial changes could be established in the soil C/N ratio, in the humic acid/fulvic acid ratio, and in the biodegradability of soil organic matter and the structural characteristics of humic acids. The increased aromaticity of humic acid (visible and IR spectroscopies) following disturbance suggests increased biogeochemical activity and/or the impact of abiotic processes (such as periodic fires) selectively removing aliphatic constituents. The overall results indicate low potential soil fertility, the sustainable preservation of which depends more on features related to quality than on the total amount of the soil organic matter, which shows aromatization parallel to its degree of association with the mineral fraction.
Construction and Characteristic Analysis of Dynamic Stress Coupling Simulation Models for the Attitude-Adjustable Chassis of a Combine Harvester
Authors: Chai Xiaoyu , Hu Jinpeng , Ma Tianle , Liu Peng , Shi Maolin , Zhu Linjun , Zhang Min , Xu Lizhang
Published: August 2024

The combine harvester equipped with attitude-adjustment functionality significantly enhances its adaptability to complex terrain but often struggles to maintain the reliability of its mechanisms. Therefore, investigating the dynamic load characteristics of the attitude-adjustment mechanism becomes imperative. This article employed the DEM–FMBD (Discrete Element Method–Flexible Multibody Dynamics) bidirectional coupling simulation method to establish a multibody dynamic model of a tracked combine harvester. The study delved into the interaction mechanism and dynamic stress response characteristics between the tracked chassis and the complex terrain under various height adjustments, lateral adjustment angles, longitudinal adjustment angles, and different field-ridge crossing methods. Finally, the accuracy of the coupled simulation model was validated through a constructed stress detection system. The research findings revealed that the displacement and tilt angle deviation of the hydraulic cylinders utilized to execute the chassis adjustment actions in the constructed coupled simulation model was less than 5%, and the deviation between the simulation results and the actual maximum dynamic stress under multiple working conditions ranged from 7% to 15%. This verification confirmed the effectiveness of the DEM–FMBD coupled simulation method. Under different adjustment conditions, the maximum stress position was consistently distributed in the same area of the left-front and left-rear rotating arms. The primary and secondary effects of the various parts of the adjustment mechanism on the overall reliability of the chassis were as follows: left front > right front > left rear > right rear. By implementing the middle height with the adjustment strategy, the dynamic stress extreme value of the adjustment mechanism can be effectively reduced by 21.98%, thereby enhancing the structural stability of the chassis.
Pharmacokinetics of Doxycycline in Plasma and Milk after Intravenous and Intramuscular Administration in Dairy Goats
Authors: Martínez José , Escudero Elisa , Badillo Elena , Yuste María Teresa , Galecio Juan Sebastián , Marin Pedro
Published: August 2024

Doxycycline is a second-generation tetracycline, marketed in different species for treating infections caused by susceptible bacteria. Little information is available on the pharmacokinetics of doxycycline in lactating goats. The objective of this study was to establish the disposition kinetics of doxycycline after parenteral administration (intravenous and intramuscular) in dairy goats and its elimination in milk. A cross-over model was designed (n = 6). Doxycycline was dosed at 5 mg/kg for intravenous administration and 20 mg/kg for extravascular administrations. Noncompartmental pharmacokinetic methods were used to calculate plasma concentration–time data. The Vz value suggests a moderate distribution of this antibiotic in goats, with a value of 0.85 L/kg. A low bioavailability (F = 45.60%) of doxycycline following an intramuscular injection was observed, with all animals exhibiting signs of lameness. Doxycycline rapidly crossed the blood–milk barrier, but exposure to the antimicrobial and the concentrations reached in milk were lower than those obtained in plasma. Although PK/PD ratios may be low with the pharmacokinetic data obtained with this formulation of doxycycline, at this dose and route of administration, doxycycline after IM administration could be useful for infections by moderate or highly susceptible bacteria in the mammary gland of goats. However, it may be necessary to test different doses of doxycycline or other routes of administration to achieve better surrogate markers and to establish repeated dosing regimens and clinical efficacy.
Correction: Schilling-Hazlett et al. On-Farm Methane Mitigation and Animal Health Assessment of a Commercially Available Tannin Supplement in Organic Dairy Heifers. Animals 2024, 14, 9
Authors: Schilling-Hazlett Ashley , Raynor Edward J. , Thompson Logan , Velez Juan , Place Sara , Stackhouse-Lawson Kim
Published: August 2024

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