bluuebunny/crossref_metadata_2025 huggingface dataset:
Experience with the Use of B-RAF Inhibitor Vemurafenib in the Treatment of Hairy Cell Leukemia
Authors: Al-Radi L.S. , Smirnova Svetlana Yurevna , Moiseeva T.N. , Piskunova I.S. , Plastinina L.V. , Novikova D.V. , Gemdzhian E.G. , Galstyan G.M.
Published: September 2022

Background. The standard and effective treatment of hairy cell leukemia (HCL) involves purine analogs, interferon-а (IFN-а) administration, and splenectomy. However, primary resistant HCL and early relapses (within 2-3 years after achieving remission) remain clinical challenges. Due to myelotoxicity of cladribine and slow effect of IFN-а, these drugs can be administered neither in deep neutropenia/agranulocytosis patients (especially in case of infectious complications) nor in patients with IFN-а allergy/intolerance. Aim. To report clinical experience with vemurafenib, a B-RAF inhibitor, in HCL with BRAFV600E mutation in treatment-resistant patients with contraindications to standard therapy. Materials & Methods. The study enrolled 39 HCL patients aged 24-78 years (median 55 years), 13 women and 26 men. HCL was diagnosed in accordance with the WHO 2017 criteria. Vemurafenib 240 mg was administered once or twice a day within 3 months. Three groups of patients were analyzed: those with early relapses and resistant HCL (n = 7), those with deep neutropenia/agranulocytosis (with and without infectious complications, n = 29), and those with IFN-а intolerance (n = 3). Results. In 6 (86 %) out of 7 patients from group 1 (with early relapses and resistant HCL) a complete course of treatment was carried out, which included vemurafenib with subsequent standard cladribine chemotherapy and further consolidation with rituximab. Complete remission was achieved in 5 (71 %) patients, and partial remission was achieved in 1 (14 %) patient. The 7th patient was a non- responder. In 28 (97 %) out of 29 patients from group 2 with deep neutropenia/agranulocytosis, hematologic recovery was reported which allowed for further basic treatment with cladribine. In 1 patient vemurafenib appeared to be ineffective. In 3 patients from group 3 with IFN-а intolerance, vemurafenib administration was used as a stage of treatment preceding cladribine therapy. Cladribine treatment resulted in complete remission in 2 (67 %) patients and partial remission in 1 (33 %) patient. Conclusion. In HCL with BRAFV600E mutation, low-dose vemurafenib can be effective in patients with relapsed/refrac- tory disease as well as deep neutropenia with life-threatening infectious complications. In addition to that, vemurafenib administration can be used in cases of IFN-а intolerance as a stage of treatment of HCL with BRAFV600E mutation which precedes the basic cladribine therapy.
Multiple Myeloma: Nuances of Minimal Residual Disease Diagnosis and Monitoring with the Use of Multicolor Flow Cytometry
Authors: Galtseva I.V. , Nikiforova Kseniya Aleksandrovna , Davydova Yu.O. , Kapranov N.M. , Solov’ev M.V. , Parovichnikova E.N. , Mendeleeva L.P.
Published: September 2022

The assessment of minimal residual disease (MRD) by multicolor flow cytometry (MFC) is a rapidly growing area of laboratory studies. In recent years, it has become particularly valuable for hematologists. Although the MFC analysis of plasma cells in multiple myeloma patients is sufficiently standardized, there are differences in methods of sample preparation, monoclonal antibody combinations being used as well as in cytometric data evaluation. The present paper summarizes the key international and domestic data on the MFC analysis of plasma cells and documents the authors’ own experience with MFC analysis in multiple myeloma over the last few years.
The Importance of Complementary Immunological Markers in the Diagnosis of Minimal Residual Disease in Multiple Myeloma
Authors: Tolstykh E.E. , Chuvadar O.S. , Semenova A.A. , Kupryshina N.A. , Kolbatskaya O.P. , Klyuchagina Yu.I. , Kolomeitsev O.A. , Tumyan G.S. , Tupitsyn Nikolai Nikolaevich
Published: September 2022

Background. The population of non-tumor plasma cells in healthy subjects’ bone marrow is known to be fairly heterogeneous. Among them, there may be a small number of CD19-, CD56+, CD45- plasma cells which differ from the main bulk of the normal plasmacytic cells by the lack of CD19 and CD45 expression and the presence of CD56 expression. It is the fact which makes the monitoring of minimal residual disease (MRD) especially challenging in multiple myeloma (MM) since normal and aberrant plasma cells should be compared. For this reason, a study of such complementary diagnostic markers as CD27, CD28, CD117, and CD81 is extremely important. Aim. To analyze the role of complementary diagnostic markers (CD27, CD28, CD117, and CD81) of MRD in MM patients at different disease stages. Materials & Methods. The present study enrolled 62 MM patients aged 31-76 years (median 58 years); 25 women and 37 men. The analysis focused on morphological and immunophenotypic properties of bone marrow plasma cells. MRD was detected by 8-color flow cytometry with the use of FACSCanto II Flow Cytometer (USA) based on EuroFlow standards. Results. At the stage of primary diagnosis of MM, the imunophenotype of plasma cells was analyzed in all 62 patients using two 8-color panels recommended by the EuroFlow Consortium (2012). In accordance with primary immunophenotyping data, MRD was evaluated on the basis of not only the main diagnostic markers of plasma cells (CD38, CD138, CD45, CD56, and CD19), but also the complementary ones, such as CD27, CD28, CD117, and CD81. The study was basically conducted after induction therapy and upon remission. With cut-off > 0.01 % of aberrant plasma cells, the MRD incidence was the following: 91.0 % with CD27, 90.6 % with CD28, 87.0 % with CD117, and 96.7 % with CD81 markers. Respectively, no MRD was detected in 9.0 % with CD27, 9.4 % with CD28, 13.0 % with CD117, and 3.3 % with CD81 markers.
Vietnamese Sign Language - Unresolved Issues
Authors: Thoa Nguyen Thi Kim
Published: September 2022

Appearing in Vietnam around 1886, today, Vietnamese Sign Language (VSL) has been a major means of communication in the deaf community in Vietnam. However, VSL has not been unified across regions, has not been officially taught in educational institutions and has not been interested by researchers. The article mainly uses the descriptive method to analyze the linguistic features of VSL in terms of phonetics, vocabulary, and grammar. Besides, the author also uses activities such as collecting documents, analyzing, synthesizing, comparing to make the necessary judgments and conclusions. The article will introduce VSL from the perspective of linguistics with phonological, lexical, and grammatical aspects - through which readers can see the unique characteristics of VSL. It also analyzes the outstanding issues, what needs to be done to move towards a unified VSL, to become the object of research in Linguistics and to be taught officially in the School. Besides, the research directions or the development of sign languages of some countries such as the US, UK... are also mentioned in the article as experiences that Vietnam can learn and absorb.
The Space of Integrable Systems from Generalised $T\bar{T}$-Deformations
Authors: Doyon Benjamin , Durnin Joseph , Yoshimura Takato
Published: September 2022

We introduce an extension of the generalised
T\bar{T}TT‾-deformation
described by Smirnov-Zamolodchikov, to include the complete set of
extensive charges. We show that this gives deformations of S-matrices
beyond CDD factors, generating arbitrary functional dependence on
momenta. We further derive from basic principles of statistical
mechanics the flow equations for the free energy and all free energy
fluxes. From this follows, without invoking the microscopic Bethe ansatz
or other methods from integrability, that the thermodynamics of the
deformed models are described by the integral equations of the
thermodynamic Bethe-Ansatz, and that the exact average currents take the
form expected from generalised hydrodynamics, both in the classical and
quantum realms.
Contexto sociocultural y construcción de identidades en jóvenes de escuelas rurales
Authors: Cifuentes Garzón José Eduardo
Published: September 2022

La investigación tiene como objetivo comprender la incidencia de los contextos socioculturales en la construcción de identidades en jóvenes rurales, a través del análisis etnográfico hermenéutico del discurso en estudiantes y un profesor de una institución pública rural de Cundinamarca, Colombia. El estudio fue desarrollado desde un enfoque cualitativo, a través de la etnografía hermenéutica con estudio de caso, con la participación de 16 estudiantes con edades entre los 11 y 15 años, de sexto a noveno de educación básica secundaria, y 1 docente del modelo educativo telesecundaria. Se utilizaron instrumentos y técnicas de recolección de información cualitativas (el protocolo esperanzas y temores, la entrevista estructurada, los relatos de vida y la cartografía social). Los resultados muestran que los contextos socioculturales afectan la enseñanza, el aprendizaje y la construcción de identidades en los jóvenes rurales y que se requieren currículos contextualizados, construidos desde el reconocimiento de los territorios, la comprensión del entorno sociocultural y del trato diferenciado entre las poblaciones, según las condiciones de vulnerabilidad de cada persona, desde una mirada intercultural.
Habilidades de cognición social en un grupo de adolescentes de bajos recursos socioeconómicos de Medellín, Colombia
Authors: Restrepo Jorge Emiro , Gómez Botero Mónica , Castañeda Quirama Tatiana , Molina González David
Published: September 2022

Introducción: en este estudio se realizó un análisis comparativo, de acuerdo con el estrato socioeconómico, de tres habilidades de cognición social (teoría de la mente, empatía y reconocimiento de emociones) en un grupo de adolescentes de Medellín. Metodología: se realizó una investigación cuantitativa comparativa transversal con una muestra de 130 adolescentes de ambos sexos a quienes se les administraron las pruebas Sistema Internacional de Imágenes Afectivas, el Test de la Mirada y el Índice de Reactividad Interpersonal. Resultados: los resultados de los análisis comprobaron la hipótesis, en algunas de las variables, de que los niveles socioeconómicos más bajos tienen niveles más bajos de habilidades de cognición social, especialmente en la teoría de la mente y la empatía, pero no en la evaluación emocional de las expresiones faciales. Discusión: la adolescencia es un periodo crítico del neurodesarrollo. Neurobiológicamente, durante este periodo ocurren cambios significativos en el denominado cerebro social. Conclusión: no todas las habilidades socio-cognitivas tienen la misma sensibilidad a los efectos ambientales durante su desarrollo.
Commercialization of intellectual property objects in industrial enterprises
Authors: Pererva Petro , Maslak Mariya
Published: September 2022

Introducing the results of innovative activity into economic circulation is one of the essential characteristics of an effective industrial enterprise. Commercializing intellectual property objects involves coordinated production and commercial activity, adopting and implementing scientifically based decisions. This is necessary to successfully pass an intellectual product through all stages of its life cycle.The purpose of this study is to form market processes for commercializing intellectual property objects at industrial enterprises, finding the most effective option for their introduction into economic circulation.The theoretical investigation of the problem made it possible to identify and analyze various possible conceptual approaches to commercializing intellectual property in an industrial enterprise. Among them are market push, market pull, engineering, and reengineering commercialization models.Separate stages of forming the market model for commercializing intellectual property in an industrial enterprise are highlighted. First, the methodological principles of the vertical, horizontal, and vertical-horizontal market processes of intellectual property commercialization have been developed. The peculiarities of an intellectual product’s life cycle are determined; based on this, a market model of intellectual property’s life cycle (model of successive changes) is proposed. Finally, for each of the proposed market processes, the main advantages and disadvantages of their practical use are determined, as well as the areas of their most effective usage.
KÜLTÜREL BİR MİRAS OLAN TAŞPINAR (AKSARAY) EL DOKUMA HALILARININ KORUNMASI VE TURİSTİK ÜRÜN OLARAK SÜRDÜRÜLEBİLİRLİĞİ
Authors: CEYLAN Serdar , EMİROĞLU AYDIN Fatma , BULUT İhsan
Published: September 2022

Araştırmanın amacı, araştırma sahasındaki el dokuma halı kültürünün geçmişini ve günümüzdeki durumunu anlamak ve bu kültürel mirasın korunması ve sürdürülebilirlik durumunu değerlendirmektir. Çalışma nitel araştırma yöntemi ile yapılmış olup, görüşme ve gözlem tekniği uygulanmıştır. Nitel bulgular, alıntılama tekniğine göre kelime, cümle ve paragraflar şeklinde betimlenerek yorumlanmıştır. Araştırmanın bulgularına göre, el dokuma halıcılığının araştırma sahasında Selçuklu döneminden günümüze kadar yapılageldiği tespit edilmiştir. Önceden her evde halı dokunmakta iken, yaklaşık 25 yıldır Taşpınar Belediyesi’nin halı dokuma evinde halılar dokunmaktadır. Kasabada kadınların sosyal güvencesiz ve düzenli bir ücret almadan halı dokudukları, dokudukları halı miktarına göre düşük bir ücret aldıkları belirlenmiştir. Sonuç olarak, geleneksel el dokuma halılarının turizmde pazarlanabilme durumunda, kadınların ücretlerinde artış ve devamlılık olacaktır. Bu durumda yörenin geleneksel halı kültürünün korunması ve sürdürülebilirliği sağlanacaktır.
Validation of the UNICEF fiscal diagnostic tool for SDGs 6.1 and 6.2 in East and Southern Africa using the analytical hierarchy process (AHP)
Authors: Godfrey Samuel , Wambugu Mary , Parikh Priti , Tunhuma Farai
Published: September 2022

The UN High Level Panel on Water notes that a total annual capital expenditure (CAPEX) of $114 billion of $129 billion is required globally to meet the safe drinking water and sanitation targets 1 and 2 of Sustainable Development Goal 6 (SDG 6). Annual operation and maintenance expenditure (OPEX) will increase, averaging $129 billion by 2030. In Sub-Saharan Africa, $36 billion is required and UNICEF estimates $15 billion is required to meet these targets in 21 countries in East and Southern Africa. Currently, only 15% of the financial investments in the sector are accounted for, which falls significantly short of delivering SDG 6. Consequently, innovative finance tools that maximise taxes, tariffs and transfers (3ts) are required to mobilise finances for the region's sector. This paper presents a diagnostic methodology for identifying bankable and blended finance projects in East and Southern Africa's water and sanitation sector. Potential projects were identified in Malawi, Mozambique and Ethiopia. Findings from applying the AHP (analytical hierarchy process) analysis recommend the use of the decision-making tool for prioritisation and selection of water and sanitation projects in the context of multiple projects requiring blended finance. The methods are applicable to other parts of Sub-Saharan Africa to enhance project pipelines whose collective cost and revenue mitigate investment risk.
Gebelik haftasına göre küçük olmanın prematüre morbiditelerine etkisi
Authors: YILDIZ Duran , CERAN Burak , ÇAKIR Ufuk , TUĞCU Ali Ulaş , TAYMAN Cüneyt
Published: September 2022

Amaç: Gebelik yaşına göre düşük doğum ağırlığı (small for gestational age: SGA) olan prematüre bebeklerin prematüreliğe ek olarak hangi morbiditeler açısından daha riskli olduğu konusundaki kanıtlar yetersizdir. Çalışmamızda gebelik haftası <32 hafta olan SGA prematüre bebeklerin morbidite ve mortalite açısından risklerinin değerlendirilmesi amaçlanmıştır.Yöntemler: Gebelik haftası <32 hafta olup SGA olan bebeklerin morbiditeleri ve mortalite verileri, <32 gebelik haftasında doğan gebelik haftasına uygun doğum ağırlığı ile doğan (appropriate for gestational age: AGA) bebekler ile karşılaştırıldı.Bulgular: Çalışmaya 122 (%24,6) SGA ve 372 (%75,4) AGA bebek olmak üzere toplam 494 prematüre bebek dâhil edildi. Doğumda SGA olan bebeklerde AGA olanlara göre annede preeklampsi, nekrotizan enterokolit (NEK), prematüre retinopatisi (ROP), intraventiküler kanama (İVK) oranı daha yüksekti. Ayrıca SGA olanlarda AGA olanlara göre tam enteral beslenmeye geçiş zamanı, yoğun bakımda yatış süresi anlamlı olarak daha yüksekti (p<0,05).Sonuç: Gebelik haftaları benzer olsa da SGA ve prematüre olan bebeklerde, AGA olan bebeklere göre İVK, ROP ve NEK gibi prematüre morbiditeleri daha yüksekti.
Employees’ Experiences of Accepting and Adopting HR Analytics: A Phenomenology Study
Authors: Saxena Mansi , Bagga Teena , Gupta Sangeeta , Mittal Amit
Published: September 2022

Purpose:

The growing and sustaining needs of today’s globalized organizations lead to a quest for competitive advantages through 3R’s: Reframing, Repositioning, and Reinventing. The current research suggests that these mutations initiate changes and provocations in almost every segment of working culture, fostering mutation for the complete organization leaving employees to accept and act. The study aims to focus on the employee experiences and the implications during the acceptance and adoption of HR analytics.

Design/Methodology/Approach:

Using a qualitative approach, a life-world phenomenology study with 22 employees associated with HR activities or decision-making process for employees and practicing change management were interviewed for 24 – 26 weeks before and after adopting HR analytics. The interviews were analyzed and texted, which was directed at evaluating qualitative meanings through a systematic process. It is then clustered and analyzed for defining themes and the purpose of the phenomenon.

Results:

The study with the sample shows that HR analytics adoption and acceptance is not a cakewalk. The organization has to prepare its employees to adjust to new technology by supporting, encouraging, training, building the right attitude to bring change, and leading in an impactful manner.

Conclusion:

The adoption and acceptance of HR analytics among its users have various steps and criticalities. The study was conducted to highlight the emotions of employees during the transformative move toward technology adoption and usage that will help the organization develop the right model for initiating the use of HR analytics in the working culture. It provides insights and guidance for promoting ease of acceptance and adoption of HR analytics among its users.
Investigating the Relationship between Health Locus of Control and Health Behaviors: A Systematic Review
Authors: Dogonchi Mitra , Mohammadzadeh Fatemeh , Moshki Mahdi
Published: September 2022

Introduction:

Health locus of control is recognized as a factor affecting the development and promotion of health behaviors. The present study aimed to investigate the relationship between health locus of control and health behaviors.

Methods:

This systematic review was conducted by searching several databases including PubMed, Science Direct, Web of Science, Google Scholar, and Scopus from early April to early May 2021 using the keywords Health Locus of Control and Health Behaviors.

Results:

Out of the 1099 articles retrieved after the screening, 18 articles met the criteria for further analysis. A review of the studies showed that those who firmly believed in internal health control were more likely to engage in health behaviors.

Conclusion:

In line with the findings of this study, it is essential to focus on people's beliefs about the influence of internal factors and increase awareness about people's abilities to promote their health behaviors.
Macro and microelement analysis of Sargassum fluitans and Sargassum natans arriving in the coastal zone of Cancun, Quintana Roo, Mexico
Authors: Nava-Jiménez Iris Aurora , Tejeda-Vega Samuel , Cortina-Ramírez Gloria Emelí , Zarazúa-Ortega Graciela , Berriozabal-Islas Christian , Sánchez-Hernández Hugo
Published: September 2022

In recent years, the massive increase in Sargassum landings on the Mexican Caribbean coast has generated negative environmental repercussions. This study has two main objectives (1) to analyze the macro and micronutrients of Sargassum fluitans and S. natans in order to (2) use them in the local and regional industry as a biofertilizer in the production of ornamental plants. Sargasso samples were collected from floating arrivals in the sea and landfall in the area of three beaches in Cancun, Quintana Roo, Mexico in 2018. The quantification of the elements in the samples was carried out using the method of fundamental parameters. The concentration of the macronutrients Ca, Na, K and Cl was higher than the elements Mg, S, Si and Sr, as well as two orders of magnitude higher than Al and P. Additionally, the trace elements Fe, Mn, Zn, Cu, and Ni were found in both species. It is worth mentioning that most of these elements are essential to complete the life cycle of plants; therefore, S. fluitans and S. natans can be considered as an excellent natural resource and alternative as a soil improver for the cultivation of ornamental plants.
Dietary enrichment with crude protein content and feed additives (Bacillus spp. and yeast strains) improves growth performance, survival and circulating hemocytes in juvenile White shrimp, Litopenaeus vannamei
Authors: Morales-Cristóbal Yenni , Cortés-Jacinto Edilmar , Saucedo Pedro , Méndez-Martínez Yuniel , Ledea-Rodríguez José L. , Guzmán-Murillo María A. , Sánchez-Ortiz Ana C. , Aguirre-Guzmán Gabriel , Cadena-Roa Marco , Campa-Córdova Angel I.
Published: September 2022

In this study the enrichment dietary effect with different  crude protein levels (CP) and feed additives on growth, survival, feed conversion ratio (FCR), feed consumption (FC) and total hemocyte count (THC) in juvenile white shrimp Litopenaeus vannamei were evaluated. The study covered two bioassays: in the first one, juveniles were daily fed for 45 days with four experimental diets containing: (1) Control, commercial feed (35% CP); (2) 29% CP; (3) 32% CP; (4) 35% CP. After the 29% CP diet was selected, juveniles in bioassay II were daily fed for 45 days with a single CP diet complemented with probiotics: (1) Control, commercial feed (35% CP); (2) 29% CP; (3) 29% CP + Bacillus mix at 1×106 CFUg–1 feed; and (4) 29% CP + yeast mix at 1×106 CFUg–1 feed. Juvenile shrimp fed with experimental diets gained significantly more weight and increased survival, FCR, FC and THC compared with control diet. However, differences among experimental diets were not significant. In bioassay II, juvenile shrimp fed with experimental diet + feed additives significantly increased survival, FCR, FC and THC compared with control diet. Growth of juveniles significantly increased with 29% CP and 29% CP + yeast mix diets, compared with control group. Complementing the diet with yeast mix showed higher survival and THC of juveniles compared with the other experimental treatments. Different CP levels in shrimp diet improved growth, survival and circulating hemocytes, and addition of mixed yeast as feed additive induced better survival and immune response in juvenile shrimp.
Extraction, Profiling and Characterization of Phytosterols and Triterpenoids from Pili (Canarium ovatum Engl.) Pulp Oil Exhibiting Antioxidant and Antibacterial Properties
Authors: Dumandan Nico , Kagaoan Annie Cita , Acda Ranelle , Tumambing Caren , Pham Laura
Published: September 2022

Pili (Canarium ovatum Engl.), an indigenous tree found in the
Philippines, is highly regarded for its fruit due to its high economic
value. During processing, the pulp is often discarded as waste but
contains considerable amounts of oil and bioactive minor lipid
components. The present study explored the antioxidant and antibacterial
properties of saponified diethyl ether extract of pili pulp oil and
relate this activity to the nature of compounds present in the extract
thru GCMS. The extract indicated the elution of 18 major compounds which
are mostly cyclic triterpenic (α- and β-amyrin, lupenone β-amyrone) and
phytosterol (β-sitosterol, brassicasterol, stigmasterol) class of
compounds. Characterization of the bioactivity of the extract showed
high antioxidant activities measured by DPPH radical scavenging and
lipid peroxidation inhibition activities that were comparable with that
of α-tocopherol. Moreover, an observed bacteriocidal activity was
demonstrated by the extract against E. coli and S. typhi with MIC values
of 40 and 35 µg/mL, respectively. The observed bioactivity of the pili
pulp oil extract can be attributed to these compounds which has high
potential for the development and utilization in the food sector.
Disentangling genetic risks for metabolic syndrome
Authors: Walree Eva S. van , Jansen Iris E. , Bell Nathaniel Y. , Savage Jeanne E. , Leeuw Christiaan de , Nieuwdorp Max , Sluis Sophie van der , Posthuma Danielle
Published: September 2022

A quarter of the world’s population is estimated to meet the criteria for metabolic syndrome, a cluster of cardiometabolic risk factors that promote development of coronary artery disease and type II diabetes, leading to increased risk of premature death and significant health costs. In this study we investigate whether the genetics associated with metabolic syndrome components mirror their phenotypic clustering. A multivariate approach that leverages genetic correlations between fasting glucose, high-density lipoprotein cholesterol, systolic blood pressure, triglycerides, and waist circumference was used; which revealed that these genetic correlations are best captured by a genetic one factor model. The common genetic factor genome-wide association study (GWAS) detects 235 associated loci, 174 more than the largest GWAS on metabolic syndrome to date. Of these loci, 53 (22.5%) overlap with loci identified for two or more metabolic syndrome components, indicating that metabolic syndrome is a complex, heterogeneous disorder. Associated loci harbour genes that show increased expression in the brain, especially in GABAergic and dopaminergic neurons. A polygenic risk score drafted from the metabolic syndrome factor GWAS predicts 5.9% of the variance in metabolic syndrome. These results provide mechanistic insights in the genetics of metabolic syndrome and suggestions for drug targets, especially fenofibrate, which has the promise of tackling multiple metabolic syndrome components. 
Dynamic Ins2 gene activity defines β-cell maturity states
Authors: Chu Chieh Min Jamie , Modi Honey , Ellis Cara , Krentz Nicole A.J. , Skovsø Søs , Zhao Yiwei Bernie , Cen Haoning , N Noursadeghi , Panzhinskiy Evgeniy , Hu Xiaoke , Dionne Derek A. , Xia Yi Han , Xuan Shouhong , Huising Mark O. , Kieffer Timotyh J. , Lynn Francis C. , Johnson James D.
Published: September 2022

Transcriptional and functional cellular specialization has been described for insulin-secreting β-cells of the endocrine pancreas. However, it is not clear whether β-cell heterogeneity is stable or reflects dynamic cellular states. We investigated the temporal kinetics of endogenous insulin gene activity using live cell imaging, with complementary experiments employing FACS and single cell RNA sequencing, in β-cells from Ins2GFP knock-in mice. In vivo staining and FACS analysis of islets from Ins2GFP mice confirmed that at a given moment, ~25% of β-cells exhibited significantly higher activity at the evolutionarily conserved insulin gene Ins2. Live cell imaging over days captured Ins2 gene activity dynamics in single β-cells. Autocorrelation analysis revealed a subset of oscillating cells, with mean oscillation periods of 17 hours. Increased glucose concentrations stimulated more cells to oscillate and resulted in higher average Ins2 gene activity per cell. Single cell RNA sequencing showed that Ins2(GFP)HIGH β-cells were enriched for markers of β-cell maturity. Ins2(GFP)HIGH β-cells were also significantly less viable at all glucose concentrations and in the context of ER stress. Collectively, our results demonstrate that the heterogeneity of insulin production, observed in mouse and human β-cells, can be accounted for by dynamic states of insulin gene activity. 
ALTERAÇÃO CPC 29 - ATIVOS BIOLÓGICOS E PRODUTOS AGRÍCOLAS, INDÚSTRIA SUCROENERGÉTICA DO ESTADO DE SÃO PAULO
Authors: Paz Khristóferson Teixeira , Nunes Rodolfo Vieira , Sales George André Willrich
Published: September 2022

O CPC 29 proporcionou uma evolução técnico conceitual para a contabilidade rural e agrícola. A norma trouxe o conceito de mensuração dos ativos biológicos a valor justo menos despesa de venda, no reconhecimento inicial e nos finais de cada período. O objeto deste estudo foi apresentar os conceitos de ativos biológicos e sua evolução conceitual até a revisão nº. 08 de 2015, evidenciando como a modificação refletiu nas demonstrações financeiras, e consequentemente nos indicadores financeiros, do segmento sucroenergético do Estado de São Paulo. Constitui-se em uma pesquisa descritiva, quantitativa e bibliográfica baseado em demonstrações publicadas pelas companhias do setor sucroenergético entre os anos 2015 e 2016. Os resultados evidenciam claramente os efeitos da evolução conceitual da norma, com ênfase na apresentação fidedigna dos indicadores e das demonstrações financeiras, que ao final de cada período apresentou uma menor oscilação nos resultados, em sintonia com as práticas internacionais de contabilidade.
Mechanical Properties of Mineralized Collagen Type I Rat-Tail Tendon Fascicles
Authors: López-Santiago Jeromi G. , Sundaram Paul A.
Published: September 2022

Type I collagen fibers transmit forces, dissipate energy, and prevent mechanical failure in normal tissues. Mineralization of collagen fibers is proposed to strengthen these structural proteins as a possible therapeutic option for small tears in soft tissues such as cemental tears in periodontal ligaments.  In the present study, collagen fascicles extracted from the tail tendons of male Sprague-Dawley rats were tested in a MiniMat tensile tester at different strain rates. The fascicles were previously immersed in SBF to induce mineralization and were maintained in a moist condition during mechanical testing. Mineralization of the fascicles resulted in an increase in the modulus of elasticity and tensile strength with minimal change in percentage elongation to failure. From SEM/EDS, calcium phosphate deposits formed on the fascicles indicating a high probability of intrafibrillar mineralization resulting in the observed improvement in mechanical properties.
Linear Alkylbenzene Sulfonate Removal by Oxidative Ozonation Coupled with UV/H2O2 Oxidative Process
Authors: Teran Francisco J. C. , Santos Rafael R. , Silva Yuri L. , Cuba Renata M. F. , Silveira Jéssica R.
Published: September 2022

In this study, the results of the application of advanced oxidative processes to remove linear alkylbenzene sulfonate (LAS) from wastewater produced in the laundry industry are presented. Photocatalysis with UV radiation and oxygen peroxide (H2O2) was applied followed by ozonation (O3). LAS removal was higher than 90% in the first 60 min. H2O2 application based on COD reached its most effective concentration for the rate of [1:2.5] with O3 acting as a polishing agent. Excessive foam formation caused by the bubbling effect led to the necessity of introducing a lag into the process, retarding the O3 application in 30 min. Therefore, complete oxidation was achieved with a low concentration of LAS, and no foam was observed by the end of the process. The best COD removal results were achieved when low doses of H2O2 were applied. Using UV/H2O2/O3, 51.2% removal was achieved.
Faktor-Faktor yang Mempengaruhi Implementasi SAK EMKM pada UMKM Kota Padang
Authors: Wulandari Dewi , Arza Fefri Indra
Published: September 2022

This study aims to determine the factors that influence the implementation of SAK EMKM on UMKM in the city of Padang. The data used in this study are primary data sourced from questionnaires given to the owners of UMKM in the city of Padang. Testing is done by using regression. The results showed that simultaneously the independent variables consisting of socialization of SAK EMKM, utilization of information technology, accounting knowledge, education level of the owner, omzet and length of business did not significantly affect the dependent variable, namely the implementation of SAK EMKM. Partially, the socialization of SAK EMKM and the owner's level of education have a positive effect on the implementation of SAK EMKM. While the use of information technology, accounting knowledge, omzet and length of business have no significant effect on the implementation of SAK EMKM in Padang City.
Intersection of the Personal and the Political Life in Nelson Mandela’s Long Walk to Freedom
Authors: Borchetia Akash
Published: September 2022

The autobiography is a genre that focuses on the personal life of the autobiographer as narrated by him. In an autobiography, the autobiographical narrator engages in the reconfiguration and reconstruction of his own personal history which is inextricably connected to the social, political, economic and many other discursive contexts. Nelson Mandela’s autobiography Long Walk to Freedom records the tension between the personal and the political in the context of Mandela’s life and shows how it resulted in the formation of a larger personal identity. Although Mandela’s autobiography revolves around the personal, the subjects that it incorporates are much broader and complex than a personal narrative. It is at the same time the story of his personal life and the story of how his country gained independence as seen and experienced by him. Mandela’s autobiography not only represents his personal life but it is also representative of an era. In writing his autobiography, he also writes the major political events that effected millions of lives. The autobiography documents Mandela’s life, the struggle against apartheid in South Africa and the struggle across Africa to shake off the control of colonial powers. This paper will address the interlacing of details pertaining to the individual as well as the political activist with a support base across Africa.
Nilai Praksis Pancasila Sebagai Modal Pengembangan Sumber Daya Manusia Era Society 4.0 dalam Rangka Mendukung Pertahanan Negara
Authors: Inthaly Anouphone , Almubaroq Hikmat Zakky
Published: September 2022

AbstractPancasila has the nature of basic values which are the essence of the five precepts. The five precepts include values regarding the One Godhead, humanity, unity, democracy, and justice. The nature of Pancasila is universal, in other words, ideals, goals, and good and true values are contained in Pancasila as a basic value. Pancasila is classified as a philosophy, a view of life, and in a practical sense. Philosophy of Pancasila has a function and role as a guide and guide in attitudes, behaviour and actions in everyday life, in the life order of the nation, society and state for the Indonesian people. The value of Pancasila praxis is used as the basic capital in the development of human resources in the era of society 4.0 which must have a view of life and behaviour that is strong and has character in facing increasingly complex challenges. This paper was written using a qualitative method with a literature study approach that looks at the practical value of Pancasila as the basic capital for developing human resources in the era of society 4.0 in supporting national defence by using the theory of Pancasila philosophy and human resource development.------------AbstrakPancasila memiliki sifat nilai dasar yang dimana hakikat dari kelima sila. Kelima sila tersebut antara lain nilai nilai mengenai Ketuhanan Yang Maha Esa, kemanusiaan, persatuan, kerakyatan, dan keadilan. Sifat dari Pancasila yaitu universal, dengan kata lain, cita-cita, tujuan, serta nilai-nilai yang baik dan bena terkandung dalam Pancasila sebagai nilai dasar. Pancasila digolongkan sebagai filsafat, pandangan hidup, dan dalam arti praktis. Filsafat Pancasila memiliki fungsi dan peranan sebagai pedoman dan pegangan dalam sikap, tingkah laku dan perbuatan dalam kehidupan sehari-hari, dalam tatanan hidup berbangsa, bermasyarakat dan bernegara bagi bangsa Indonesia. Nilai praksis pancasila digunakan sebagai modal dasar dalam pembangunan sumber daya manusia di era society 4.0 dimana harus memiliki pandangan hidup dan perilaku yang kuat dan berkarakter dalam menghadapi tantangan yang semakin kompleks. Tulisan ini ditulis dengan metode kualitatif dengan pendekatan studi literatur yang melihat bagaimana nilai praksis pancasila sebagai modal dasar pengembangan sumber daya manusia di era society 4.0 dalam mendukung pertahanan Negara dengan menggunakan teori filsafat Pancasila dan pengembangan SDM.
Bezpośrednie inwestycje zagraniczne w Polsce w latach 2010-2020
Authors: Daszyńska Sylwia , Sobczak Magdalena , Śliwińska Aleksandra
Published: September 2022

Celem artykułu jest analiza poziomu bezpośrednich inwestycji zagranicznych w polskiej gospodarce. Artykuł dotyczy zagadnień związanych z pojęciem, istotą i rolą bezpośrednich inwestycji zagranicznych oraz występujących dwóch rodzajach tych inwestycji: greenfield i brownfield. Dokonując analizy statystycznej omówiono ogólną wartość bezpośrednich inwestycji zagranicznych w Polsce w latach 2010-2020 wraz z ich podziałem na poszczególne sektory gospodarki. Przedstawiono także wpływ BIZ na gospodarkę Polski.
Tribological Behavior of a Contact Pin on Cylinder CuSn7 Bronze Rubbing Against 20MnCr5 Steel in Dry Sliding with Electrical Current
Authors: Djamel Bekhouche , Ali Bouchoucha , Hamid Zaidi
Published: September 2022

The tribological behavior of CuSn7 Bronze and Steel 20MnCr5 couple was studied as a function of mechanical and electrical parameters and the contact geometry (pin on cylinder) under ambient environment. To do this, a pin on cylinder tribometer (the test machine is a kind of pin-on-slip ring) was used. Experimental results show that these parameters have a significant effect on the friction and on the wear. Indeed, the load has a significant influence on the tribological behavior of the couple both with and without electrical current. In the other hand, the friction coefficient and wear of the pin against the cylinder decreases especially at high values of electrical current. Moreover, the observed wear mechanisms are: adhesion, abrasion, oxidation, arc erosion and plastic deformation. At high applied electrical current and loads, the main wear mechanism is the arc erosion and severe plastic deformation. The discussion of the obtained results is based on examination of the worn surfaces and analysis performed on interfacial phenomena observed during the friction process.
A modified Post Widder operators preserving $e^{Ax}$
Authors:   ", Gupta Vijay ,   Department of Mathematics, Netaji Subhas University of Technology, Sector 3 Dwarka, New Delhi 110078, India e-mail: vijaygupta2001@hotmail.com", Tachev Gancho ,   "Department of Mathematics, University of Architecture Civil Engineering and Geodesy, Sofia, Bulgaria e-mail: gtt fte@uacg.bg"
Published: September 2022

In the present paper, we discuss the approximation properties of modified Post-Widder operators, which preserve the test function $e^{Ax}$. We establish weighted approximation and a direct quantitative estimate for the modified operators.
La ciberseguridad en la era de hipercompetitividad: ¿puede la Union Europea afrontar los nuevos retos?
Authors:   Asesor sénior, BusinessEurope, Munkøe Malthe , Mölder Holger ,   Profesor titular de Relaciones Internacionales, TalTech-Tallinn University of Technology.
Published: September 2022

En su discurso de 2021 sobre el estado de la Unión, la presidenta de la Comisión Europea, Ursula von der Leyen, recalcó la necesidad de mejorar la ciberseguridad de la UE. El panorama de las amenazas es diverso y cambiante: desinformación y noticias falsas, ataques informáticos contra infraestructuras gubernamentales, injerencia en elecciones de terceros países, etc. Ante ello, en diciembre de 2020, la UE dio a conocer una nueva Estrategia de Ciberseguridad que incluye iniciativas legislativas e institucionales: desde la revisión de la Directiva NIS –la primera legislación sobre ciberseguridad de la UE– hasta el establecimiento de un ciberescudo para identificar los ataques cibernéticos a gran escala. Para ser efectiva en este campo, en que participan una multitud de actores, la UE deberá garantizar la cooperación y el intercambio de información de forma sólida, tanto a escala nacional como europea, así como con la OTAN.
TOPLUMSAL CİNSİYET EŞİTLİĞİ ÖLÇEĞİNİN GELİŞTİRİLMESİ
Authors: KANDEMİR Ayhan , SEZGİN NARTGÜN Şenay
Published: September 2022

Bu çalışmada öğretmenlerin toplumsal cinsiyet eşitliği algılarını ortaya çıkarmaya ilişkin toplumsal cinsiyet eşitliği ölçeğinin geliştirilmesi amaçlanmıştır. Ölçeğin geçerlilik çalışması için açımlayıcı ve doğrulayıcı faktör analizlerinden yararlanılmıştır. Açımlayıcı ve doğrulayıcı faktör analizleri ile nihai çalışma için gerekli veriler üç farklı çalışma grubundan elde edilmiştir. Yapılan faktör analizleri sonucunda toplumsal cinsiyet eşitliği ölçeği geliştirilmiş ve ölçeğin 5 boyut ve 25 maddeden oluştuğu görülmüştür. Sonraki aşamada ölçek Bolu il genelinde görev yapan toplam 493 ortaokul öğretmenine uygulanmıştır. Betimsel analizler öncesinde geliştirilen ölçeğin Cronbach’s Alpha sonuçlarına bakılmıştır. Elde edilen sonuçlara göre ölçeğin aile yaşamı boyutunda .92; okul yaşamı boyutunda .91; sosyal yaşam boyutunda .86; iş yaşamı boyutunda .93; aile etkisi boyutunda .89 ve ölçek toplamında .95 güvenirliğe sahip olduğu bulunmuştur. Ölçeğin güvenirliğinin test edilmesi sonucunda betimsel analiz yapılmış ve öğretmenlerin toplumsal cinsiyet eşitliğine yönelik algı düzeylerinin; aile yaşamı, okul yaşamı, sosyal yaşam, iş yaşamı ve ölçek toplamında, “büyük ölçüde katılıyorum”; aile etkisi boyutunda ise “tam katılıyorum” olduğu sonucuna ulaşılmıştır.
ÜNİVERSİTE PERSONELİNİN KALİTE SÜREÇLERİ ALGISININ İNCELENMESİ: GİRESUN ÜNİVERSİTESİ ÖRNEĞİ
Authors: TOPÇU Elif , ÖZDEM Güven
Published: September 2022

Bu araştırmada, yükseköğretim kurumlarında iç paydaş konumunda bulunan akademik ve idari personelin üniversitede yürütülen kalite süreçlerini algılama düzeylerini ortaya koymak amaçlanmıştır. Çalışma, akademik ve idari personelin üniversitedeki kalite süreçlerine ilişkin algılarının incelenmesi amacıyla bir ölçek geliştirilmesi ve personelin kalite süreçlerine ilişkin algılarının cinsiyet, yaş, öğrenim düzeyi vb. değişkenlere göre incelenmesi amacıyla yapılmış tarama modelinde bir araştırmadır. Araştırmada çalışma grubunu, 2019-2020 eğitim-öğretim yılında Giresun Üniversitesi’nde görev yapan 197 akademik ve idari personel oluşturmaktadır. Araştırmanın verileri, araştırmacı tarafından geliştirilen “Yükseköğretimde Kalite Süreçleri Algısı Ölçeği” adı verilen 26 maddelik ölçeğin çalışma grubuna uygulanması yoluyla elde edilmiştir. Yapılan analizler sonucunda, Giresun Üniversitesi’nde çalışan akademik ve idari personelin üniversitede yürütülen kalite süreçlerine ilişkin algılarının cinsiyete, yaşa, kurumdaki hizmet süresine, kadrosunun bulunduğu birime ve hizmet içi eğitim alma durumuna göre farklılık göstermediği tespit edilmiştir.
EVDE EĞİTİM PROGRAMININ EISNER’IN EĞİTSEL UZMANLIK VE ELEŞTİRİ MODELİ’NE GÖRE DEĞERLENDİRİLMESİ
Authors: MUTLUER Özgül , GÜROL Mehmet
Published: September 2022

Bu araştırmada, sağlık durumu nedeniyle okula devam edemeyen öğrencilerin evde eğitimi uygulamalarının Eisner’ın Eğitsel Eleştiri Modeli ile görüşmeler ve ders gözlemleri yapılarak değerlendirilmesi amaçlanmıştır. Programın Eğitsel Eleştiri modeline göre derinlemesine ve bütüncül yaklaşım ile incelenmesinde olgubilim deseninden yararlanılmıştır. Araştırma 2019-2020 eğitim öğretim yılında Yalova il ve ilçelerindeki evde eğitim uygulamaları üzerinde gerçekleştirilmiştir. Araştırmada 4 öğretmen, 4 öğrenci ve velisi, 4 okul yöneticisi ile görüşmeler yapılmış, araştırmacı tarafından 2 öğretmenin dersi gözlemlenmiştir. Araştırma kapsamında verilerin toplanmasında, evde eğitim uygulamalarını gerçekleştiren öğretmen, öğrenci ve velilerin uygulamaya ilişkin görüşlerini almak amacıyla yarı yapılandırılmış görüşmelerden, programın uygulanmasına ilişkin bilgi elde etmek amacıyla ders gözlemlerinden yararlanılmıştır. Araştırma sonucunda, Eisner’ın Eğitsel Uzmanlık ve Eleştiri Modeli’ne göre değerlendirilen Evde Eğitim Programı’nın yürütülmesinde birtakım sorunlarla karşılaşılmaktadır. Bu sorunların başında, öğrencinin sosyal etkileşimden uzak kalması, eğitim ortamındaki araç-gereç eksikliği ve evde eğitim programının yalnızca miğfer dersleri (Hayat Bilgisi, Sosyal Bilgiler, Fen Bilimleri, Matematik, Türkçe, Din Kültürü ve Ahlak Bilgisi) kapsaması gelmektedir. Ayrıca öne çıkan önemli bir sonuç da, evde eğitim programının sağlık sorunları nedeniyle okula devam edemeyen öğrencilerin eğitim haklarının temin edilmesinde büyük bir önem taşımasıdır.

Evde eğitim programı sayesinde, sağlık problemi yaşayan öğrenciler, eğitimlerine ara vermek zorunda kalmamaktadır.
SINIF ÖĞRETMENİ ADAYLARININ HAYVAN SEVGİSİ VE DUYARLILIKLARI
Authors: UTKUGÜN Ceren
Published: September 2022

Bu araştırma sınıf öğretmeni adaylarının hayvan sevgisi ve duyarlılıkları konusunda görüşlerinin incelenmesi amacıyla yapılmıştır. Bu araştırmada öğretmen adaylarının hayvan sevgisine yönelik görüş ve deneyimleri ile hayvanlara duyarlılığı nasıl algıladıklarına odaklanıldığı için temel nitel araştırma yaklaşımı tercih edilmiştir. Araştırmanın çalışma grubu seçkisiz olmayan örnekleme türlerinden uygun örnekleme yöntemiyle seçilen Eğitim Fakültesi 4. sınıfta öğrenim görmekte olan 67 sınıf öğretmeni adayından oluşmaktadır. Araştırmanın verileri 2019/2020 Bahar yarıyılı sonunda altı adet açık uçlu sorudan oluşan anket kullanılarak dijital ortamda toplanmıştır. Elde edilen veriler betimsel analizle çözümlenmiş, tablolar biçiminde sunulmuş, frekanslarla ifade edilmiş, öğretmen adaylarının görüşlerinden yapılan doğrudan alıntılarla desteklenmiştir. Araştırma sonucunda elde edilen bulgulara göre; öğretmen adaylarının hayvanları sevdiği ve korumaya yönelik farkındalık sahibi oldukları tespit edilmiştir. Öğretmen adaylarının kendi hayatlarından örnekler vermeleri, hayvanların yaşam koşulları ile kendi yaşam koşullarını kıyaslayarak empati kurabilmeleri, hayvanların maruz kaldıkları bazı durumlar için “Ne yazık ki, Çok yazık!” gibi duygusal ifadeler kullanmaları, hayvan beslemenin zorlukları hakkında çoğunlukla olumlu ifadeler kullanmaları hayvan sevgisi ve duyarlılığına sahip olduklarını göstermektedir.
When Science Races: the Standard of Care and Medical Negligence in the Times of Covid-19
Authors: Šolc Martin
Published: September 2022

When a new disease emerges, there are at first no specific medicinal products to treat it. This has also been the case in the Covid-19 pandemic. Scientists and health professionals have been trying to establish the best treatments possible using the already-existing medicines that are normally used for different indications. The off-label use of medicinal products is a standard part of medical practice. If it meets certain criteria, it is not contradictory to the standard of care. Nevertheless, the urgency of the pandemic situation brings about new issues. What amount of data on efficacy and safety should be considered sufficient to scientifically justify the off-label use of a particular medicine? How should health professionals reflect the rapid scientific developments and high levels of uncertainty in their clinical practice? How can be these factors influenced by the politicisation of medicine? The paper deals with the outlined questions in order to analyse and concretise the criteria for off-label use of medicinal product in the specific context of the Covid-19 pandemic.