bluuebunny/crossref_metadata_2025 huggingface dataset:
Micro-Mechanical Hyperelastic Modelling for (Un)Filled Polyurethane with Considerations of Strain Amplification
Authors: Razavi Saman H. , Beber Vinicius C. , Mayer Bernd
Published: May 2024

Polyurethane (PU) is a very versatile material in engineering applications, whose mechanical properties can be tailored by the introduction of active fillers. The current research aims to (i) investigate the effect of active fillers with varying filler loads on the mechanical properties of a PU system and (ii) develop a micro-mechanical model to describe the hyperelastic behavior of (un)filled PU. Three models are taken into consideration: without strain amplification, with constant strain amplification, and with a deformation-dependent strain amplification. The measured uniaxial stress–strain data of the filled PU nanocomposites reveal clear reinforcement due to the incorporation of carbon black at 5, 10 and 20 wt%. In low concentration (1 wt%), for two different grades of carbon black and a fumed silica, it results in a reduction in the mechanical properties. The micro-mechanical model without strain amplification has a good agreement with the measured stress–strain curves at low concentrations of fillers (1 wt%). For higher filled concentrations (5–15 wt%), the micro-mechanical model with constant strain amplification leads to a better prediction performance. For samples with a larger filler volume fraction (20 wt%) and for a commercial adhesive, the model with a deformation-dependent strain amplification effect leads to the best predictions, i.e., highest R2 regarding curve fitting.
Gadolinium Doping Modulates the Enzyme-like Activity and Radical-Scavenging Properties of CeO2 Nanoparticles
Authors: Sozarukova Madina M. , Kozlova Taisiya O. , Beshkareva Tatiana S. , Popov Anton L. , Kolmanovich Danil D. , Vinnik Darya A. , Ivanova Olga S. , Lukashin Alexey V. , Baranchikov Alexander E. , Ivanov Vladimir K.
Published: May 2024

Their unique physicochemical properties and multi-enzymatic activity make CeO2 nanoparticles (CeO2 NPs) the most promising active component of the next generation of theranostic drugs. When doped with gadolinium ions, CeO2 NPs constitute a new type of contrast agent for magnetic resonance imaging, possessing improved biocatalytic properties and a high level of biocompatibility. The present study is focused on an in-depth analysis of the enzyme-like properties of gadolinium-doped CeO2 NPs (CeO2:Gd NPs) and their antioxidant activity against superoxide anion radicals, hydrogen peroxide, and alkylperoxyl radicals. Using an anion-exchange method, CeO2:Gd NPs (~5 nm) with various Gd-doping levels (10 mol.% or 20 mol.%) were synthesized. The radical-scavenging properties and biomimetic activities (namely SOD- and peroxidase-like activities) of CeO2:Gd NPs were assessed using a chemiluminescent method with selective chemical probes: luminol, lucigenin, and L-012 (a highly sensitive luminol analogue). In particular, gadolinium doping has been shown to enhance the radical-scavenging properties of CeO2 NPs. Unexpectedly, both bare CeO2 NPs and CeO2:Gd NPs did not exhibit SOD-like activity, acting as pro-oxidants and contributing to the generation of reactive oxygen species. Gadolinium doping caused an increase in the pro-oxidant properties of nanoscale CeO2. At the same time, CeO2:Gd NPs did not significantly inhibit the intrinsic activity of the natural enzyme superoxide dismutase, and CeO2:Gd NPs conjugated with SOD demonstrated SOD-like activity. In contrast to SOD-like properties, peroxidase-like activity was observed for both bare CeO2 NPs and CeO2:Gd NPs. This type of enzyme-like activity was found to be pH-dependent. In a neutral medium (pH = 7.4), nanoscale CeO2 acted as a prooxidant enzyme (peroxidase), while in an alkaline medium (pH = 8.6), it lost its catalytic properties; thus, it cannot be regarded as a nanozyme. Both gadolinium doping and conjugation with a natural enzyme were shown to modulate the interaction of CeO2 NPs with the key components of redox homeostasis.
Enhanced Nanotwinned Copper Bonding through Epoxy-Induced Copper Surface Modification
Authors: Lu Tsan-Feng , Wang Pei-Wen , Cheng Yuan-Fu , Yen Yu-Ting , Wu YewChung Sermon
Published: May 2024

For decades, Moore’s Law has neared its limits, posing significant challenges to further scaling it down. A promising avenue for extending Moore’s Law lies in three-dimensional integrated circuits (3D ICs), wherein multiple interconnected device layers are vertically bonded using Cu–Cu bonding. The primary bonding mechanism involves Cu solid diffusion bonding. However, the atomic diffusion rate is notably low at temperatures below 300 °C, maintaining a clear and distinct weak bonding interface, which, in turn, gives rise to reliability issues. In this study, a new method of surface modification using epoxy resin to form fine grains on a nanotwinned Cu film was proposed. When bonded at 250 °C, the interfacial grains grew significantly into both sides of the Cu film. When bonded at 300 °C, the interfacial grains extended extensively, eventually eliminating the original bonding interface.
Surface-Pore-Modified N-Doped Amorphous Carbon Nanospheres Tailored with Toluene as Anode Materials for Lithium-Ion Batteries
Authors: Shan Shiran , Yuan Chunze , Tan Guangsu , Xu Chao , Li Lin , Li Guoqi , Zhang Jihao , Weng Tsu-Chien
Published: May 2024

The surface modification of amorphous carbon nanospheres (ACNs) through templates has attracted great attention due to its great success in improving the electrochemical properties of lithium storage materials. Herein, a safe methodology with toluene as a soft template is employed to tailor the nanostructure, resulting in ACNs with tunable surface pores. Extensive characterizations through transmission electron microscopy (TEM), scanning electron microscopy (SEM), Raman spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and nitrogen adsorption/desorption isotherms elucidate the impact of surface pore modifications on the external structure, morphology, and surface area. Electrochemical assessments reveal the enhanced performance of the surface-pore-modified carbon nanospheres, particularly ACNs-100 synthesized with the addition of 100 μL toluene, in terms of the initial discharge capacity, rate performance, and cycling stability. The interesting phenomenon of persistent capacity increase is ascribed to lithium ion movement within the graphite-like interlayer, resulting in ACNs-100 experiencing a capacity upswing from an initial 320 mAh g−1 to a zenith of 655 mAh g−1 over a thousand cycles at a rate of 2 C. The findings in this study highlight the pivotal role of tailored nanostructure engineering in optimizing energy storage materials.
Repeated Injection of Very Small Superparamagnetic Iron Oxide Particles (VSOPs) in Murine Atherosclerosis: A Safety Study
Authors: Haase Tobias , Ludwig Antje , Stach Anke , Mohtashamdolatshahi Azadeh , Hauptmann Ralf , Mundhenk Lars , Kratz Harald , Metzkow Susanne , Kader Avan , Freise Christian , Mueller Susanne , Stolzenburg Nicola , Radon Patricia , Liebl Maik , Wiekhorst Frank , Hamm Bernd , Taupitz Matthias , Schnorr Jörg
Published: May 2024

Citrate-coated electrostatically stabilized very small superparamagnetic iron oxide particles (VSOPs) have been successfully tested as magnetic resonance angiography (MRA) contrast agents and are promising tools for molecular imaging of atherosclerosis. Their repeated use in the background of pre-existing hyperlipidemia and atherosclerosis has not yet been studied. This study aimed to investigate the effect of multiple intravenous injections of VSOPs in atherosclerotic mice. Taurine-formulated VSOPs (VSOP-T) were repeatedly intravenously injected at 100 µmol Fe/kg in apolipoprotein E-deficient (ApoE KO) mice with diet-induced atherosclerosis. Angiographic imaging was carried out by in vivo MRI. Magnetic particle spectrometry was used to detect tissue VSOP content, and tissue iron content was quantified photometrically. Pathological changes in organs, atherosclerotic plaque development, and expression of hepatic iron-related proteins were evaluated. VSOP-T enabled the angiographic imaging of heart and blood vessels with a blood half-life of one hour. Repeated intravenous injection led to VSOP deposition and iron accumulation in the liver and spleen without affecting liver and spleen pathology, expression of hepatic iron metabolism proteins, serum lipids, or atherosclerotic lesion formation. Repeated injections of VSOP-T doses sufficient for MRA analyses had no significant effects on plaque burden, steatohepatitis, and iron homeostasis in atherosclerotic mice. These findings underscore the safety of VSOP-T and support its further development as a contrast agent and molecular imaging tool.
Synthesis, Surface Modification and Magnetic Properties Analysis of Heat-Generating Cobalt-Substituted Magnetite Nanoparticles
Authors: Ognjanović Miloš , Bošković Marko , Kolev Hristo , Dojčinović Biljana , Vranješ-Đurić Sanja , Antić Bratislav
Published: May 2024

Here, we present the results of the synthesis, surface modification, and properties analysis of magnetite-based nanoparticles, specifically Co0.047Fe2.953O4 (S1) and Co0.086Fe2.914O4 (S2). These nanoparticles were synthesized using the co-precipitation method at 80 °C for 2 h. They exhibit a single-phase nature and crystallize in a spinel-type structure (space group Fd3¯m). Transmission electron microscopy analysis reveals that the particles are quasi-spherical in shape and approximately 11 nm in size. An observed increase in saturation magnetization, coercivity, remanence, and blocking temperature in S2 compared to S1 can be attributed to an increase in magnetocrystalline anisotropy due to the incorporation of Co ions in the crystal lattice of the parent compound (Fe3O4). The heating efficiency of the samples was determined by fitting the Box-Lucas equation to the acquired temperature curves. The calculated Specific Loss Power (SLP) values were 46 W/g and 23 W/g (under HAC = 200 Oe and f = 252 kHz) for S1 and S2, respectively. Additionally, sample S1 was coated with citric acid (Co0.047Fe2.953O4@CA) and poly(acrylic acid) (Co0.047Fe2.953O4@PAA) to obtain stable colloids for further tests for magnetic hyperthermia applications in cancer therapy. Fits of the Box-Lucas equation provided SLP values of 21 W/g and 34 W/g for CA- and PAA-coated samples, respectively. On the other hand, X-ray photoelectron spectroscopy analysis points to the catalytically active centers Fe2+/Fe3+ and Co2+/Co3+ on the particle surface, suggesting possible applications of the samples as heterogeneous self-heating catalysts in advanced oxidation processes under an AC magnetic field.
Inhibitory Effects of Metformin for Pancreatic Neuroendocrine Neoplasms: Experimental Study on Mitochondrial Function
Authors: Maruzen Shogo , Munesue Seiichi , Okazaki Mitsuyoshi , Takada Satoshi , Nakanuma Shinichi , Makino Isamu , Gong Linxiang , Kohno Susumu , Takahashi Chiaki , Tajima Hidehiro , Yamamoto Yasuhiko , Yagi Shintaro
Published: May 2024

Although pancreatic neuroendocrine neoplasms (panNENs) are much less common and have a better prognosis than exocrine pancreatic cancers, their recurrence rate is not low, even in Grade 1 (World Health Organization classification) panNEN. Recently, there have been several reports that the progression-free survival in patients with unresectable panNEN could be improved by an antidiabetic drug, metformin, with the co-treatment of everolimus or a somatostatin analog. In this study, we aimed to evaluate the effects of metformin on cell metabolism and viability using the panNEN cell line, QGP-1, and RIN-m in culture. We observed an inhibitory effect of metformin on QGP-1 cell proliferation in a dose-dependent manner. Metformin was found to decrease the oxygen consumption rate in QGP-1 and RIN-m cells after metformin 48 h treatment and immediately after exposure. Cell proliferation was suppressed after metformin treatment. Phosphorylated adenosine monophosphate-activated protein kinase (AMPK) expression was increased, and cyclin D1 expression was decreased in RIN-m cells 24 h after metformin treatment by Western blotting in a dose-dependent manner. In conclusion, suppressive mitochondrial respiration and AMPK activation by metformin are, thus, suggested to inhibit panNEN cell viability and cell survival.
Innovative Application of Polyether Amine as a Recyclable Catalyst in Aerobic Thiophenol Oxidation
Authors: Chen Lingxia , Li Junyu , Ni Ke , Qin Xinshu , Wang Lijun , Hou Jiaman , Wang Chao , Li Xuan , Wang Minlong , An Jie
Published: May 2024

Polyether amines are versatile compounds characterized by a flexible structure, consisting of polyoxypropylene and polyoxyethylene as the backbone, with amine groups at each end. They have widespread applications in various industrial processes and daily life. Despite their versatility, the utilization of polyether amines as base catalysts is rare. In this study, one kind of three-arm polyether amine 1 was employed as an environmentally friendly, cost-effective catalyst for the aerobic oxidation of thiophenols, leading to the synthesis of disulfides. The oxidative coupling of thiols serves as a fundamental pathway for the production of disulfides, which are vital in both chemical and biological processes. In contrast to known methods for thiol oxidation, this polyether amine-based catalytic process eliminates the need for expensive stoichiometric oxidants and minimizes the formation of over-oxidized by-products. Using a mere 0.5 mol % of the polyether amine 1 as the catalyst, a remarkable > 96% yield was achieved for all 16 tested substrates, encompassing a diverse range of functional groups, under the catalytic aerobic oxidation conditions. Furthermore, it is noteworthy that over 90% of the polyether amine catalyst can be efficiently recovered for reuse without loss of activity, making this a sustainable and cost-effective catalytic approach.
Hyperbaric Oxygen in Otorhinolaryngology: Current Concepts in Management and Therapy
Authors: Collettini Andrea , Zoccali Federica , Barbato Christian , Minni Antonio
Published: May 2024

Background: In otorhinolaryngology and head and neck surgery, oxygen is a therapeutic tool used for various pathologies. Oxidative stress is the imbalance between the production of free radicals (ROS) and the antioxidant capacity of the body, which can represent the pathogenesis of several pathologies or contribute to their worsening. This narrative review aims to analyze the benefits, indications, and side effects of hyperbaric oxygen therapy (HBOT) in different head and neck disorders. Methods: The search was carried out on multiple electronic databases such as PubMed and Google Scholar, and prospective, randomized, and reviewed studies were analyzed from January 1982 to February 2024. Results and Conclusions: The most common tools used to manage oxidative stress in the ear, nose, and throat (ENT) field are continuous positive airway pressure (CPAP) and HBOT. A common ENT pathology, while the latter can be used for osteoradionecrosis treatment in head and neck cancer patients, infections, malignant external otitis, head and neck reconstruction, facial cosmetic surgery, and among patients with sudden sensorineural hearing loss. From our analysis, it emerged that HBOT is a currently used effective therapy in various ENT pathologies’ treatment, alone or in association with other treatments; it can guarantee functional recovery and healing depending on the type of pathology for which it is used and on its severity.
Novel Genotype of HA Clade 2.3.4.4b H5N8 Subtype High Pathogenicity Avian Influenza Virus Emerged at a Wintering Site of Migratory Birds in Japan, 2021/22 Winter
Authors: Mihiretu Berihun Dires , Usui Tatsufumi , Kiyama Masahiro , Soda Kosuke , Yamaguchi Tsuyoshi
Published: May 2024

Surveillance of avian influenza virus (AIV) was conducted in the 2021–2022 winter season at a wintering site of migratory Anatidae in Japan. An H5N8 subtype high pathogenicity AIV (HPAIV) with a unique gene constellation and four low pathogenicity AIVs (LPAIVs) were isolated from environmental samples. The genetic origin of the HPAIV (NK1201) was determined with whole-genome sequencing and phylogenetic analyses. Six of NK1201’s eight genes were closely related to HA clade 2.3.4.4b H5N8 subtype HPAIVs, belonging to the G2a group, which was responsible for outbreaks in poultry farms in November 2021 in Japan. However, the remaining two genes, PB1 and NP, most closely matched those of the LPAIVs H7N7 and H1N8, which were isolated at the same place in the same 2021–2022 winter. No virus of the NK1201 genotype had been detected prior to the 2021–2022 winter, indicating that it emerged via genetic reassortment among HPAIV and LPAIVs, which were prevalent at the same wintering site. In addition, experimental infection in chickens indicated that NK1201 had slightly different infectivity compared to the reported infectivity of the representative G2a group H5N8 HPAIV, suggesting that the PB1 and NP genes derived from LPAIVs might have affected the pathogenicity of the virus in chickens. Our results directly demonstrate the emergence of a novel genotype of H5N8 HPAIV through gene reassortment at a wintering site. Analyses of AIVs at wintering sites can help to identify the emergence of novel HPAIVs, which pose risks to poultry, livestock, and humans.
Predictive Value of Neutrophil-to-Monocyte Ratio, Lymphocyte-to-Monocyte Ratio, C-Reactive Protein, Procalcitonin, and Tumor Necrosis Factor Alpha for Neurological Complications in Mechanically Ventilated Neonates Born after 35 Weeks of Gestation
Authors: Cioboata Daniela Mariana , Boia Marioara , Manea Aniko Maria , Costescu Oana Cristina , Costescu Sergiu , Doandes Florina Marinela , Popa Zoran Laurentiu , Sandesc Dorel
Published: May 2024

This prospective study investigated the association between elevated neutrophil-to-monocyte ratio (NMR), lymphocyte-to-monocyte ratio (LMR), C-reactive protein (CRP), procalcitonin, and tumor necrosis factor-alpha (TNF-alpha) and the risk of developing neurological complications in mechanically ventilated neonates. The aim was to evaluate these biomarkers’ predictive value for neurological complications. Within a one-year period from January to December 2022, this research encompassed neonates born at ≥35 weeks of gestational age who required mechanical ventilation in the neonatal intensive care unit (NICU) from the first day of life. Biomarkers were measured within the first 24 h and at 72 h. Sensitivity, specificity, and area under the curve (AUC) values were calculated for each biomarker to establish the best cutoff values for predicting neurological complications. The final analysis included a total of 85 newborns, of which 26 developed neurological complications and 59 without such complications. Among the studied biomarkers, TNF-alpha at >12.8 pg/mL in the first 24 h demonstrated the highest predictive value for neurological complications, with a sensitivity of 82%, specificity of 69%, and the highest AUC (0.574, p = 0.005). At 72 h, TNF-alpha levels greater than 14.3 pg/mL showed further increased predictive accuracy (sensitivity of 87%, specificity of 72%, AUC of 0.593, p < 0.001). The NMR also emerged as a significant predictor, with a cutoff value of >5.3 yielding a sensitivity of 78% and specificity of 67% (AUC of 0.562, p = 0.029) at 24 h, and a cutoff of >6.1 showing a sensitivity of 76% and specificity of 68% (AUC of 0.567, p = 0.025) at 72 h. Conversely, CRP and procalcitonin showed limited predictive value at both time points. This study identifies TNF-alpha and NMR as robust early predictors of neurological complications in mechanically ventilated neonates, underscoring their potential utility in guiding early intervention strategies. These findings highlight the importance of incorporating specific biomarker monitoring in the clinical management of at-risk neonates to mitigate the incidence of neurological complications.
The Burden of Not Doing
Authors: Aricò Maurizio
Published: May 2024

The cultural and professional growth of a physician is a long process, spanning over more than 10 years [...]
Assisted Reproductive Technologies: A New Player in the Foetal Programming of Childhood and Adult Diseases?
Authors: Faa Gavino , Manchia Mirko , Fanos Vassilios
Published: May 2024

Assisted reproductive technology (ART) is an emerging field in medicine that incorporates complex procedures and has profound ethical, moral, social, religious, and economic implications not just for the individuals who have access to this method but also for society. In this narrative review, we summarise multiple aspects of ART procedures and the possible consequences on the mother and newborn. Moreover, we provide an overview of the possible long-term consequences of ART procedures on the health of newborns, although longitudinal evidence is particularly scant. Users should be informed that ART procedures are not risk-free to prepare them for the possible negative outcomes that may occur in the perinatal period or even in childhood and adulthood. Indeed, risk estimates point to increased liability for major nonchromosomal birth defects; cardiovascular, musculoskeletal, and urogenital (in male newborns) defects; and any other birth defects. Less certainty is present for the risk of neuropsychiatric sequelae in children conceived through ART. Thus, its application should be accompanied by adequate counselling and psychological support, possibly integrated into specific multidisciplinary clinical programmes.
Early Postnatal Administration of Erythropoietin and Its Association with Neurodevelopmental Outcomes and Incidence of Intraventricular Hemorrhage and Hypoxic-Ischemic Encephalopathy: A Four-Week Observational Study
Authors: Costescu Oana Cristina , Manea Aniko Maria , Boia Eugen Radu , Cioboata Daniela Mariana , Doandes Florina Marinela , Enatescu Ileana , Costescu Sergiu , Prodan Mihaela , Boia Marioara
Published: May 2024

This study aimed to investigate the impact of early erythropoietin (EPO) administration on the neurodevelopment of newborns, specifically focusing on its effects on hypoxic-ischemic encephalopathy (HIE) and intraventricular hemorrhage (IVH). The primary objective was to determine whether early EPO administration could impact the short-term neurodevelopmental outcomes and provide safety in neonates at risk for neurodevelopmental disorders. Conducted at the “Louis Turcanu” Children’s Emergency Clinical Hospital in Timisoara, Romania, this observational study included 121 neonates receiving EPO and 130 No EPO controls. EPO was administered within the first 48 h of life, with doses of 1000 U/kg that escalated to 2000 U/kg if necessary. Besides observing the occurrence of IVH and HIE, this study measured clinical and biochemical markers, including LDH, blood glucose, urea, creatinine, CPK, CRP, PCT, and erythropoietin levels alongside hematology and coagulation profiles. There were no significant differences in baseline characteristics between the groups. The EPO group showed significant reductions in LDH levels from days 1–3 to 7–10 (695.0 U/L to 442.0 U/L) and the APTT value (54.0 s) compared with the No EPO group (38.0 s). Notably, early EPO administration was associated with a significant decrease in HIE severity (beta coefficient: −0.38, p = 0.001). Additionally, lower gestational ages and hemoglobin levels correlated with increased severity of HIE. By week four, there was a significant reduction in moderate and severe HIE cases in the EPO group compared with controls (p = 0.001). Early administration of EPO in neonates significantly reduced the severity of IVH and HIE, suggesting its potential as a neuroprotective agent in neonatal care.
Navigating the Complex Terrain of Photography and Temporality
Authors: Hausken Liv
Published: May 2024

In recent years, discourses on photography have undergone a transformative shift from a focus on the individual photograph’s connection to memory, pastness, loss, and death towards exploring photographic imagery as shared, networked, and continuously circulating in a ubiquitous present. The general claim for the temporal dimension in this shift is that photography is no longer seen as a mere witness or reservoir of the past but instead points to or participates in an active present. Against this claim, the article argues for broadening the perspective, drawing on resources across C.P. Snow’s “two cultures”—the arts and humanities vs. the natural sciences—to develop a better conception of time and a more varied and useful selection of photographic practices. In this connection, the article provides a reading of Paul Ricoeur’s compound concept of “the third time”, cutting across the two cultures. Drawing on insights from Patrick Maynard and Kelley Wilder, basic premises for photographic practices in the natural sciences are brought into the discussions of the discursive shift from a preoccupation with photography and the past to an interest in photography and the present. The purpose of this paper is to develop a better ground for navigating intricate questions about the relationship between photography and time.
Three Different Currents of Thought to Conceive Justice: Legal, and Medical Ethics Reflections
Authors: De Micco Francesco , Scendoni Roberto
Published: May 2024

The meaning of justice can be defined according to a juridical, human, theological, ethical, biomedical, or social perspective. It should guarantee the protection of life and health, personal, civil, political, economic, and religious rights, as well as non-discrimination, inclusion, protection, and access to care. In this review, we deal with three theoretical concepts that define justice in all its aspects. (1) The utilitarian theory, which justifies moral statements on the basis of the evaluation of the consequences that an action produces, elaborating a pragmatic model of medical science. (2) The libertarian theory, which considers freedom as the highest political aim, thus absolutizing the rights of the individual; here, the principle of self-determination, with respect to which the principle of permission/consent is the fundamental presupposition, plays a central role in the definition of the person. (3) The iusnaturalist theory, in which man’s moral freedom is identified with the ability to act by choosing what the intellect indicates to him as good; the natural moral law that drives every conscience to do good is therefore realized in respect for the person in the fullness of his rights. In conclusion, different forms and conceptions of justice correspond to different organizations of society and different ways of addressing ethical issues in the biomedical domain.
The Evolution of Humanitarian Aid in Disasters: Ethical Implications and Future Challenges
Authors: Arcos González Pedro , Gan Rick Kye
Published: May 2024

Ethical dilemmas affect several essential elements of humanitarian aid, such as the adequate selection of crises to which to provide aid and a selection of beneficiaries based on needs and not political or geostrategic criteria. Other challenges encompass maintaining neutrality against aggressors, deciding whether to collaborate with governments that violate human rights, and managing the allocation and prioritization of limited resources. Additionally, issues arise concerning the safety and protection of aid recipients, the need for cultural and political sensitivity, and recognition of the importance of local knowledge, skills, and capacity. The appropriateness, sustainability, and long-term impact of actions; security risks for aid personnel; and the need for transparency and accountability are also crucial. Furthermore, humanitarian workers face the duty to report and engage in civil activism in response to human rights violations and the erosion of respect for international humanitarian law. Lastly, the rights of affected groups and local communities in the decision-making and implementation of humanitarian aid are vital. The traditional foundations and approaches of humanitarian aid appear insufficient in today’s landscape of disasters and crises, which are increasingly complex and divergent, marked by a diminished capacity and shifting roles of various actors in alleviating suffering. This article reviews the historical evolution of the conceptualization of humanitarian aid and addresses some of its ethical challenges and dilemmas.
The Influence of Lobbies: Analyzing Group Consensus from a Physics Approach
Authors: Merlone Ugo , Dal Forno Arianna
Published: May 2024

In this paper, we study the influence of a small group of agents (i.e., a lobby) that is trying to spread a rumor in a population by using the known model proposed by Serge Galam. In particular, lobbies are modeled as subgroups of individuals who strategically choose their seating in the social space in order to protect their opinions and influence others. We consider different social gatherings and simulate, using finite Markovian chains, opinion dynamics by comparing situations with a lobby to those without a lobby. Our results show how the lobby can influence opinion dynamics in terms of the prevailing opinion and the mean time to reach unanimity. The approach that we take overcomes some of the problems that behavioral economics and psychology have recently struggled with in terms of replicability. This approach is related to the methodological revolution that is slowly changing the dominant perspective in psychology.
Exercise Physiology: A Review of Established Concepts and Current Questions
Authors: Matthews Michael J. , Kanungo Shibani , Baker Robert J. , Kenter Keith
Published: May 2024

Exercise physiology is the science that studies the processes of physical activity and their impact on the body. It usually requires a multidisciplinary approach with a team of experts because of the multiple physiological systems involved. At the cellular level, exercise can trigger a cascade of events that involve metabolic pathways, muscle recruitment and conditioning, neuromuscular adaptations, and optimization of energy production. On a systematic level, this has involved the cardiovascular system, the respiratory system, the musculoskeletal system, the peripheral and central nervous systems, and even the endocrine system to improve adaptation to meet the demands of exercise, improving strength and endurance with the goal of maximizing performance. This field, which began largely with a focus on the kinetics of oxygen consumption and the relationship between aerobic and anaerobic metabolism, has expanded with technological advancements such as wearable devices, advanced imaging techniques, and genomics, which has allowed for a greater appreciation of the physiologic responses of exercise at the level of molecular and cellular interactions. Recently, this science has evolved into the study of overall health promotion and disease prevention to meet individual fitness needs and goals. This philosophy, which is captured by the motto “Exercise is Medicine”, has been adopted as a Global Health Initiative by the World Health Organization (WHO). Despite the advancements in technology and impactful, large-scale studies, a variety of questions, such as how physical activity interacts with aging to affect physical and cognitive function, how inactivity influences acute and chronic disease states, and how we maximize human performance in extreme conditions like microgravity environments, remain. The purpose of this review is to present and discuss established concepts, controversial topics, and unanswered questions within exercise physiology that have allowed this field to become a science that embraces the overall well-being of individuals.
Tracking Sweet Potato Leaf Curl Virus through Field Production: Implications for Sustainable Sweetpotato Production and Breeding Practices
Authors: Andreason Sharon A. , McKenzie-Reynolds Petrina , Whitley Kaitlyn M. , Coffey John , Simmons Alvin M. , Wadl Phillip A.
Published: May 2024

Sweet potato leaf curl virus (SPLCV) is a whitefly-transmitted begomovirus infecting sweetpotato and other morning glory (Convolvulaceae) species worldwide. The virus is widespread at the USDA, ARS, U.S. Vegetable Laboratory (USVL), and testing of germplasm maintained in the breeding program indicates nearly 100% infection in storage roots of materials propagated for at least four years. Prior to the public release of new germplasm, viruses must be eliminated via laborious and time-consuming meristem-tip culture. The identification of virus-free seedlings early in the selection process can offer an alternative to meristem-tip culture. In this study, we investigated the transmission of SPLCV over two years of consecutive field plantings (early and late) of sweetpotato. While SPLCV is endemic at the USVL, virus transmission pressure over the typical cultivation season is unknown, and avoidance of virus transmission paired with the selection and maintenance of clean material may be a viable alternative to virus elimination. In 2022, the storage roots of 39 first-year seedling (FYS) selections were tested for SPLCV after early-season cultivation, revealing a single selection (2.6%) with a positive test. Similar testing was conducted in 2023 with no SPLCV-positive FYS selections detected. To further assess SPLCV acquisition in the field, replicated late-season plantings of each selected FYS (n = 37) were monitored from planting to harvest. Testing was conducted at 60 and 120 days after planting (DAP). Approximately 35% of the bulk samples were infected at 60 DAP, and infection increased to 52.3% by 120 DAP. Testing of individuals within selected positive bulked samples did not support 100% infection at harvest. Altogether, these results demonstrate that SPLCV transmission during early planting is sufficiently low to facilitate the maintenance of virus-free selections, offering an alternative to virus cleaning and a cultivation strategy that may be leveraged for production.
Salicylic Acid and Calcium Chloride Seed Priming: A Prominent Frontier in Inducing Mineral Nutrition Balance and Antioxidant System Capacity to Enhance the Tolerance of Barley Plants to Salinity
Authors: Ben Youssef Rim , Jelali Nahida , Martínez-Andújar Cristina , Abdelly Chedly , Hernández José Antonio
Published: May 2024

The current investigation aims to underline the impact of salicylic acid or calcium chloride seed pre-treatments on mineral status and oxidative stress markers, namely levels of electrolyte leakage (EL) and lipid peroxidation levels, measured as thiobarbituric reactive substances (TBARS), and the activity of some antioxidant enzymes in roots and leaves of plants in two barley species grown under various salt treatments. Overall, our results revealed that salinity inhibits essential nutrient absorption such as iron, calcium, magnesium and potassium and stimulates the absorption of sodium. Also, this environmental constraint induced oxidative stress in plants in comparison with the control conditions. This state of oxidative stress is reflected by an increase in TBARS content as well as the stimulation of EL values. In addition, salinity induced disturbances in the activity of antioxidant enzymes, which were mainly dependent on the applied salt concentration and the species. In addition, Hordeum marinum maintained high antioxidant enzyme activity and low levels of oxidative stress parameters, which reinforces its salt-tolerant character. Importantly, salicylic acid or calcium chloride seed priming alleviated the mineral imbalance and the oxidative damage induced by salinity. Moreover, seed priming improves iron, calcium magnesium and potassium content and limitsthe accumulation of sodium. Also, both treatments not only decrease TBARS levels and limit EL, but they also stimulate the antioxidant enzyme activities in the leaves and roots of the stressed plants as compared with stressed plants grown from non-primed seeds. Interestingly, the beneficial effects of the mentioned treatments were more notable on Hordeum vulgare species.
Bead-Free Electrospun Nanofibrous Scaffold Made of PVOH/Keratin/Chitosan Using a Box–Behnken Experimental Design and In Vitro Studies
Authors: Islam Mohammad Tajul , Sharmin Afsana Al , Laing Raechel , McConnell Michelle , Ali M. Azam
Published: May 2024

Bead-free nanofibrous scaffolds composed of PVOH/keratin/chitosan were prepared using electrospinning after optimising the process parameters using a Box–Behnken experimental design. Two quadratic models were developed to optimise the fibre diameter and the diameter of fibre beads considering the voltage, flow rate, spinning distance, and amount of biopolymer as independent variables. All independent variables were found to be significant in determining responses, although not all interactions among these were significant. The models were highly effective in describing responses, with an R2 of 98.58 and 99.67%. The optimum conditions were determined to be 15.82 kV voltage, 0.25 mL/h flow rate, 105 mm spinning distance, and 30% biopolymers. The accuracy of the models was verified and found to be within an acceptable range. The bead-free nanofibrous scaffold exhibited no cytotoxicity to Human Aneuploid Immortal Keratinocyte (HaCaT) and Normal Human Dermal Fibroblast (NHDF) cell lines, enabling cell adhesion and proliferation. Both cell lines remained attached with perfect cell morphology when co-cultured on the scaffold for 30 days, indicating the scaffold’s potential for biomedical applications.
Business Process Reengineering with a Circular Economy PDCA Model from the Perspective of Manufacturing Industry
Authors: Rajić Milena Nebojša , Stanković Zorana Zoran , Mančić Marko V. , Milosavljević Pedja Miroslav , Maksimović Rado
Published: May 2024

In times of increasing awareness of sustainability and the need for efficient business processes, this study explores the integration of business process reengineering with circular economy principles within Serbian manufacturing organizations. Addressing the need for sustainable development, the research aims to propose and validate a model that harmonizes business process reengineering with the circular economy to improve environmental and organizational performance. The study conducted an extensive survey and analysis across 135 manufacturing organizations in Serbia, assessing their readiness and current practices in adopting circular economy strategies through business process reengineering, utilizing the Plan-Do-Check-Act (PDCA) model. The findings reveal a moderate level of integration, with an average implementation score of 44.70% across surveyed organizations. Notably, organizations with ISO 9001 and ISO 14001 certifications demonstrated higher levels of model implementation. The study highlights the potential of integrating business process reengineering with circular economy principles as a path to sustainable manufacturing. It also highlights the need for targeted strategies to improve management commitment, resource allocation, and participation in sustainable practices. The research contributes valuable insights for policymakers, industry stakeholders, and academic discourse, advocating for a more systematic approach to embedding circular economy principles within organizational processes for a sustainable future.
A Dynamic Propagation Numerical Model of Hydraulic Fracture Interactions with Pre-Existing Complex Natural Fractures
Authors: Li Shuangming , Zhao Huan , Wang Jianbo , Xie Xiaorui , Qin Lan , Zou Linhao , Liu Yapeng
Published: May 2024

The propagation of hydraulic fractures is highly influenced by the geological structure of the reservoir in unconventional reservoirs, such as natural fractures. In this paper, a new fluid–solid coupling dynamic model was built which presents the failure mechanism of hydraulic fracture with pre-existing simple and complex natural fractures. The cohesive element method and the maximum principal stress fracture criterion were used in the new model. An analysis was conducted to investigate the impact of various factors, including encounter angle, in situ stress, elastic modulus, and Poisson’s ratio, on the propagation of hydraulic fractures. The simulation results indicate that the encounter angle and the in situ stress are the main factors affecting the fracture morphology. When the encounter angle and the in situ stress difference are small, hydraulic fractures propagate along natural fractures. When the elastic modulus is small, it is advantageous for the advancement of both hydraulic and natural fractures. The Poisson’s ratio has a slight effect on the fracture propagation pattern.
Numerical Study of Wheat Particle Flow Characteristics in a Horizontal Curved Pipe
Authors: Xu Dongming , Li Yongxiang , Xu Xuemeng , Zhang Yongyu , Yang Lei
Published: May 2024

Energy consumption is one of the important indicators of green development. The pressure drop and the particle kinetic energy loss in the pipe bend result in high energy consumption of wheat pneumatic conveying. In this paper, the CFD-DEM method is used to study the characteristics of flow field in horizontal pipe bend. The results show that the particles converge together under the force of the curved pipe wall to form a particle rope. With increasing pipe bend ratio R/D, the aggregation of particle bundles becomes stronger and the particle spiral phenomenon decreases. The particles impact the pipe wall at an angular position of θ = 30–60° around the bend, and their velocity decreases slowly under the friction resistance of the pipe wall. The velocity loss caused by particles impacting on the pipe wall increases with increasing initial velocity. When the particle mass flow rate is 1.26 kg/s and the gas velocity is 10 m/s, the pressure drop in the bend decreases and then increases with increasing R/D. The pressure drop of the bend is smallest for R/D = 2 and increases gradually with increasing gas-phase velocity. With increasing of R/D, the wall shear force between the particles and the bending pipe decreases and then increases, and the position of the maximum force moves towards the bottom of the bending pipe. The area over which the wall shear force acts continues to decrease because of the aggregation of particle bundles. The research results provide a theory for optimal design and application of pneumatic conveying equipment for wheat particles.
Determinants for Supplier Selection Based on Hybrid Grey Theory: Case Study of the Vietnamese Coffee Industry
Authors: Ho Nguyen-Nhu-Y , Nguyen Phuong Mai , Tran Cong Thanh , Ta Huy Hung
Published: May 2024

Coffee is not merely a refreshing beverage but also invigorates people, provides relaxation, contributes to human health, and fosters closer social connections. Coffee is one of the most widely consumed beverages worldwide and the most traded commercial commodity. Moreover, the rapid development of the Vietnamese coffee industry caused some concerns due to its insufficient performance and the fierce competition within the industry. It is significant to establish an efficient supply network; notwithstanding, supplier selection has always been a challenge for companies. Therefore, this paper employs a hybrid model to determine the supplier selection criteria, a vital factor for a manufacturer under practical operating conditions. Firstly, a combined model of Grey forecasting and the Grey Fourier series is applied to forecast future rainfall and temperature data for six consecutive years. Secondly, based on the criteria, strategies, and buyer requirements, the single-objective linear programming model helps identify the outperformed suppliers. The results found that prices and location change are determinants of supplier selection, and supplier shortage is an enormous barrier for the industry. In this study, these price forecasts allow supply chain management to make informed decisions about inventory levels, transportation routes, and resource allocation to ensure smooth operation and optimize coffee supply chain management.
In Vitro Screening of Lactic Acid Bacteria with RAW264.7 Macrophages and the Immunoregulatory Mechanism
Authors: Lu Yuemei , Wu Yanyang , Pan Lina , Wang Jiaqi , Tang Rongxue , Deng Fangming , Kang Wenli , Zhao Lingyan
Published: May 2024

Lactic acid bacteria (LAB) are commonly consumed as probiotics to improve gut barrier function and boost the immune system. This study aimed to screen LAB with high immunomodulatory activity using RAW264.7 macrophages. According to the results, Limosilactobacillus reuteri AUc2301 was selected from 84 screened strains that can stimulate RAW264.7 cell proliferation. Limosilactobacillus reuteri AUc2301 significantly enhanced the phagocytosis activity of RAW264.7 cells. In the ELISA test, Limosilactobacillus reuteri AUc2301 significantly promoted the release of interleukin-6, IL-1β, the tumor necrosis factor, and nitric oxide in RAW264.7 macrophages. In addition, Limosilactobacillus reuteri AUc2301 significantly inhibited the excessive release of IL-6, IL-1β, TNF-α, prostaglandin E2 as well as NO and the high expression of cyclooxygenase-2 in RAW264.7 macrophages induced by lipopolysaccharide. In further mechanism studies, Limosilactobacillus reuteri AUc2301 could regulate the nuclear factor-κB signaling pathway in RAW264.7 macrophages. Collectively, the screened Limosilactobacillus reuteri AUc2301 showed good immunomodulatory activity in vitro, and it has the potential to be developed as a novel probiotic.
The Impact of Cr(III) and Cr(VI) on Lipid Accumulation in Chlorella pyrenoidosa
Authors: Liu Tianji , Guo Huawei , Yu Qing , Wang Yajun , Liu Huan , Zeng Yanan , Wang Yitong , Liu Chunyu , Li Junguo
Published: May 2024

In this study, Chlorella pyrenoidosa was cultured with different concentrations of Cr(III) and Cr(VI), and the changes in biomass, lipid content, protein content and total sugar content of Chlorella pyrenoidosa under different culture conditions were detected. The effects of Cr(III) and Cr(VI) on the intracellular antioxidant system and related key enzymes of lipid synthesis were analyzed. The results showed that appropriate Cr(III) and Cr(VI) concentrations could make Chlorella pyrenoidosa regulate the contents of SOD, POD, ASA, CAT and GSH in cells, improve the enzyme activity of ACC and promote lipid synthesis. The aim was to investigate the mechanism of lipid synthesis by analyzing the distribution of Cr(III) and Cr(VI) in algal cells. The lipid content of Chlorella pyrenoidosa reached its highest level at 50.43 wt% and 38.00 wt% when both Cr(III) and Cr(VI) concentrations in the culture environment were 0.5 mg/L. These values were 1.37 and 1.03 times higher than the control group, respectively. The addition of appropriate Cr(III) and Cr(VI) concentrations can increase ME enzyme activity and decrease PEPC enzyme activity, shorten the biomass accumulation cycle and prolong the lipid synthesis cycle.