bluuebunny/crossref_metadata_2025 huggingface dataset:
Life stories of elderly women with cervical cancer: a look beyond getting sick
Authors: Costa Náiade Melo , Bezerra Adriana Falangola Benjamin , Silva Keila Silene de Brito e
Published: November 2021

Abstract Chronic degenerative illnesses have currently taken on a great predominance at the epidemiological profile, by affecting specially the elderly population. Among such diseases, Cancer has been studied through the broadening of information, which brought scientific advancement for the disease care. However, such topics constantly focus on statistic data, setting the lifetime story of those people aside. This paper aimed at understanding the process of sickness among elderly women and its development up to the diagnostics of uterus cancer through getting closer to their lifetime stories. It is about a qualitative research whose methodology used was that of life history. The methodological choice aimed at providing an intersection in the lives of different women, giving visibility to their memories. Five elderly women between 62 and 89 years old participated in the research, which turns into distinctive lifetime stories, with their singularities, though they interweave before the hard reality faced by them along their aging. Their relationship with their getting-sick development is surrounded by fear into different ways. It is necessary, therefore, to look to the elderly women uniquely, regarding the social relations that interfere during their lives and determine their aging.
Políticas públicas locais para promoção da atividade física das crianças nos parques públicos
Authors: Oliveira Simone Medeiros de , Santos Maria Paula Maia dos , Silva Paula
Published: November 2021

Resumo Evidências revelam o potencial dos parques públicos para a promoção da atividade física e da saúde. A valorização desses ambientes para a promoção da atividade física das crianças pode ser uma mais-valia nas políticas públicas de promoção da saúde e prevenção do sedentarismo das crianças. O objetivo deste estudo foi a análise das políticas públicas de promoção da atividade física das crianças em parques públicos do Município de Guimarães, Portugal. Foram realizadas entrevistas semiestruturadas individuais a gestores políticos públicos locais. O tratamento dos dados foi realizado segundo a metodologia qualitativa de análise do conteúdo, donde emergiram os seguintes temas relacionados com a promoção da atividade física das crianças: parceria política (pública e intersetorial), as estratégias e os constrangimentos locais. Os resultados revelaram a necessidade de maiores esforços públicos para a valorização dos parques públicos para a promoção da atividade física das crianças. Promover políticas públicas locais que favoreçam a parceria intersetorial local poderá ser uma estratégia eficaz para a promoção da atividade física das crianças nos parques públicos.
Checklist for Theoretical Report in Epidemiological Studies (CRT-EE): explanation and elaboration
Authors: Souza Filho Breno Augusto Bormann de , Tritany Érika Fernandes , Struchiner Cláudio José
Published: November 2021

Abstract Introduction: The theory is considered essential to research, however, its value is often underestimated in development and/or reporting in epidemiological studies. Objective: To present a document for the elaboration and explanation of an instrument for theoretical reporting in epidemiological studies. Methods: A theoretical model was developed, based on the theory of Meaningful Learning and literature review, to list dimensions and variables related to the quality of theoretical reporting. The review was carried out between July 2018 and August 2019, in the databases: Medline, SciELO, LILACS, SCOPUS and Web of Science. There were no restrictions related to the period of publications. The languages used were: Portuguese, English and Spanish. Results: A checklist of 15 points was developed, related to the title (1), abstract (1), introduction (4), methods (4), results (2), discussion (2) and conclusion (1) of the articles; and presents a column for marking the information requested in the article for each point. Explanations about each point of the instrument are presented, including examples, references to studies and justifications. Conclusion: This document provides guidance for improving theoretical reporting in epidemiological research and facilitates theoretical evaluation and interpretation of studies by reviewers, editors and readers.
Sexualidade e estigma na saúde: uma análise da patologização da diversidade sexual nos discursos de profissionais da rede básica
Authors: Guimarães Rita de Cássia Passos , Lorenzo Claudio Fortes Garcia , Mendonça Ana Valéria Machado
Published: November 2021

Resumo Investigamos conteúdos estigmatizantes nos discursos de médicos(as) e enfermeiros(as) sobre a saúde da população LGBTT em 32 unidades básicas de saúde do Centro-Oeste e Nordeste brasileiros. Partindo das noções de scientia sexualis em Foucault e de estigma em Goffman, analisamos a influência da patologização da sexualidade na racionalidade desses profissionais, enquanto geradores de discursos e posturas estigmatizadores que interferem na qualidade da atenção à saúde desta população. O resultado permitiu verificar que para os(as) entrevistados(as) a identidade dos membros da população LGBTT está vinculada ao conceito de grupo de risco, compreendida como uma condição causadora de doença e transtornos mentais, além de estar associada a comportamentos moralmente condenáveis. O estudo aponta para a necessidade de processos inovadores na formação profissional que busquem problematizar a racionalidade estruturante do processo estigmatizador, com vistas a qualificar a atenção.
Community Health Agent: a professional world in search of consolidation
Authors: Alonso Carolina Maria do Carmo , Béguin Pascal Daniel , Pueyo Valérie , Duarte Francisco José de Castro Moura
Published: November 2021

Abstract The contribution of community health agents (CHAs) is strategic for overcoming the biomedical health model. However, weaknesses in defining the specific roles of this profession impose contradictions and impediments to this work, making it difficult to construct the professional world of CHAs. Thus, this study aimed to analyze the tasks performed by the CHAs to reveal the objects, values, and tools, used by these workers to help consolidate their professional world. This study is a qualitative research study guided by the principles of activity ergonomics that include documentary analysis, systematic observations, and interviews. The results showed that due to the myriad of activities performed by the CHAs, the professional world of these workers is not fully delineated. However, it is believed that the results, analysis, and discussion of the data verified in this research, can support the consolidation of the professional world of the CHAs.
Ações e estratégias de educação permanente em saúde na rede de cuidados à pessoa com deficiência
Authors: Krug Suzane Beatriz Frantz , Mocelin Guilherme , Magedanz Maria Carolina , Oliveira Brenda Raddatz de , Dubow Camila
Published: November 2021

Resumo A pesquisa visou investigar ações e estratégias de Educação Permanente em Saúde (EPS) na Rede de Cuidados à Pessoa com Deficiência (PcD), sob a perspectiva de trabalhadores e gestores da saúde. Pesquisa exploratória, tipo estudo de caso, com abordagem mista, realizada nos 13 municípios da Região 28 de Saúde do Rio Grande do Sul, com amostra de 37 sujeitos envolvidos na atenção à saúde das PCDs. Os questionários foram analisados com estatística descritiva, em frequências absolutas e relativas, e as entrevistas por Análise de Conteúdo, culminando três categorias temáticas. Os resultados apontaram que a EPS na Rede de Cuidados às PcDs constitui-se como ferramenta à qualificação das práticas profissionais, mas a maioria dos trabalhadores não participa dessas ações, pois os municípios não as oferecem. Identificou-se que os sujeitos não reconhecem situações cotidianas de trabalho, espaços e momentos informais, como ações de EPS. As dificuldades das ações de EPS foram justificadas pelas inadequadas estruturas físicas dos serviços e baixo quantitativo de profissionais na equipe. Identificou-se pequena quantidade de profissionais envolvidos e reduzido interesse com a temática da PcD, demarcada pela não participação ativa dos usuários dos serviços em ações desse campo. Assim, são indispensáveis reflexões que reconheçam as ações educativas nos ambientes laborais, transformando-as em práticas cotidianas de atenção à saúde das PCDs.
Os determinantes da eficiência na Atenção Primária à Saúde dos municípios paulistas: um modelo georreferenciado
Authors: Gontijo Tiago Silveira , Reis Ilka Afonso
Published: November 2021

Resumo Esta pesquisa teve por objetivo mensurar a eficiência dos gastos em Atenção Primária à Saúde (APS) dos municípios paulistas e avaliar sua correlação com a densidade demográfica e o tamanho populacional dos municípios, assim como com sua localização geográfica e seu PIB per capita. Realizou-se uma avaliação ex post, quantitativa e descritiva acerca da eficiência do gasto em APS para uma amostra dos municípios paulistas (n=509), considerando os dados do ano de 2015. A presente pesquisa fez uso de um modelo de Data Envelopment Analysis com Supereficiência para detectar e remover outliers. Por fim, verificou-se a magnitude da relação existente entre os escores de eficiência calculados e as variáveis não discricionárias. Verificou-se que a média dos escores de eficiência após a exclusão dos municípios supereficientes (outliers) tornou-se maior (IC99%: 0.127; 0.213). Em média, os municípios paulistas são moderadamente ineficientes no tocante aos gastos com APS (ϴ = 0.488). Destaca-se que os municípios situados na faixa Leste do Estado de SP tendem a ter maiores níveis de eficiência e que a eficiência é inversamente proporcional ao tamanho populacional. O SUS possui notado subfinanciamento, mas há espaço para melhorias na gestão dos gastos e aumento da eficiência no serviço prestado.
Atenção à Saúde do bebê na Rede Cegonha: um diálogo com a teoria de Winnicott sobre as especificidades do desenvolvimento emocional
Authors: Esswein Georgius Cardoso , Teixeira Lívia Padilha de , Lopes Rita de Cássia Sobreira , Piccinini César Augusto
Published: November 2021

Resumo O Ministério da Saúde instituiu, em 2011, a Rede Cegonha através da Portaria no 1.459, visando assegurar um atendimento integral e integrado, da gestação até os 24 meses de vida do bebê. A partir desse importante avanço, este artigo tem como objetivo promover uma análise crítica da Portaria da Rede Cegonha a partir de um diálogo com a teoria do amadurecimento pessoal de Winnicott. Os resultados são apresentados a partir de quatro eixos norteadores: Características integradoras do cuidado, em que discutimos características da Rede Cegonha favorecedoras de um cuidado integrador; Cuidar do cuidador, em que salientamos a possibilidade de essa rede colaborar com a sustentação da dupla mãe-bebê; Especificidades do cuidado à saúde materno-infantil, em que atentamos às especificidades do processo de desenvolvimento emocional inicial; e Ética do cuidado, em que destacamos a necessidade de uma postura ética implicada no cuidado. Este artigo indicou as potencialidades e fragilidades da Rede Cegonha, trazendo novas proposições, que visem aprimorar a atenção à saúde materno-infantil, sobretudo nos dois primeiros anos de vida. Por fim, salientamos que apesar de a portaria não garantir como o cuidado é operacionalizado, reiteramos o importante potencial que a Rede Cegonha possui para um cuidado integrador na atenção à saúde materno-infantil.
Práticas corporais na promoção de saúde e qualidade de vida: atuação entre Educação Física e Medicina na Escola Multicampi de Ciências Médicas do Rio Grande do Norte
Authors: Franco Marcel Alves , Silva Lilian Pereira da , Rodrigues José Damião , Aguiar Milena de Oliveira , Mendes Maria Isabel Brandão de Souza , Caminha Iraquitan de Oliveira
Published: November 2021

Resumo Este artigo objetiva identificar a compreensão das práticas corporais dos alunos do curso de Medicina da Escola Multicampi de Ciências Médicas do Rio Grande do Norte e discutir sua realização no âmbito da Atenção Básica à Saúde. Por meio uma pesquisa documental de abordagem qualitativa, analisamos os 47 relatórios finais da disciplina Práticas Corporais na promoção de saúde e qualidade de vida, que ocorreu nos períodos 2017-1, 2017-2 e 2018-1. Com a análise dos documentos, foi possível identificar de que forma os alunos compreendiam o corpo e a saúde, ao mesmo tempo em que foram promovidas vivências que auxiliaram os alunos a superar preconceitos a respeito das práticas, ressaltando sua importância no âmbito da saúde, principalmente no que condiz a uma formação médica ampliada, à atuação na Atenção Básica, de forma a serem capazes de experienciar o próprio corpo e o do outro.
Death and Dying Between Anthroposophy and Biomedicine
Authors: Bastos Raquel Littério de , Matsue Regina Yoshie , Pereira Pedro Paulo Gomes
Published: November 2021

Abstract Death and dying constantly provoke debates regarding boundaries, rules and disputes for the legitimacy of different meanings regarding processes of finalizing life. This article places special emphasis on conflicts between the therapeutic system of anthroposophy and biomedicine in Brazil. The reflections contained in the text are based on ethnographic research, carried out in multiple locations between 2012 and 2015, investigating concepts of cure in anthroposophy in three different communities: two in Brazil, and one in Switzerland. Over the course of this journey, our experience as ethnographers led us to reflect on death and dying among the Widows of Demétria, one of the anthroposophical communities in which we conducted our research. Demétria is a rural neighborhood located in the city of Botucatu, in the interior of São Paulo state. The community was first organized during the 1970s, and it consists mostly of women - both Europeans and Brazilians - who live together, sharing a lifestyle that reimagines the ethos of death as a part of the aesthetic project of Bildung, which differs significantly from the conception of the death process in biomedicine.
Promoção das Práticas Corporais/ Atividade Física nos programas de governos presidenciais do Brasil (2018): diferentes caminhos, diferentes intencionalidades
Authors: Guerra Paulo Henrique , Andrade Douglas Roque , Loch Mathias Roberto
Published: November 2021

Resumo Este estudo buscou identificar estratégias e intencionalidades relativas à promoção das práticas corporais / atividade física (PCAF) nas propostas de governo (PG) presidenciais (2018). Em posse das PG, realizamos leituras e buscas por termos relacionados a temática das PCAF. Para a análise dos dados, usamos elementos da análise de conteúdo temática. Em apenas seis (46,2%) das 13 PG deferidas foram encontradas menções às PCAF. Em cinco PG identificamos estratégias relacionadas ao esporte de recreação e em quatro às PCAF no ambiente escolar. Quanto às intencionalidades, percebemos desde aquelas mais ligadas à melhoria de aspectos clínicos de saúde e enfrentamento ao uso de drogas até as que assumem o entendimento do acesso das PCAF como direito de todos. Concluímos que o acesso às PCAF ainda não é reconhecido enquanto direito de todas as pessoas, uma vez que mais da metade das PG sequer apresenta menção ao tema e que as PG que abordaram esta temática diferiram bastante tanto em relação a suas estratégias e intencionalidades para sua promoção, indicando que o discurso sobre a promoção das PCAF pode servir a diferentes projetos de país, sendo necessária uma análise criteriosa a respeito de seus caminhos e intencionalidades.
Pedagogia crítica e o legado de Paulo Freire para a democratização da educação: entrevista com Henry Giroux
Authors: Silva Maria Vieira , Campos Maria Veranilda Mota
Published: November 2021

Resumo Paulo Freire e Henry Giroux, autores de teorizações densas e originais, referências para a educação ao longo de décadas, ressignificam conceitos para tonificar a Pedagogia Crítica e sedimentar relações democráticas no ato educativo. No contexto do centenário de Paulo Freire, a presente entrevista proporciona o encontro entre esses dois grandes intelectuais, atados por uma afinidade epistemológica nutrida por uma longa e sólida amizade. Mediante memórias e olhares interpretativos a respeito da teoria freireana, Giroux reconhece a importância do legado de Paulo Freire e reafirma a relevância política e pedagógica de sua teoria como dimensão crucial para a democratização da escola e da sociedade.
High level of infection by Toxoplasma gondii in pigs slaughtered in the city of São Luís, Maranhão
Authors: Silva Ellainy Maria Conceição , Sousa Pablo dos Santos , Carvalho Scarleth Kevia Gomes Silva de , Marques Ingrid Carolinne Lopes , Costa Francisco Borges , Costa Andrea Pereira da , Santos Larissa Sarmento dos , Braga Maria do Socorro Costa Oliveira , Abreu-Silva Ana Lúcia , Machado Rosangela Zacarias , Carvalho Neta Alcina Vieira de
Published: November 2021

Abstract A serological, molecular and histopathological study was carried out in order to investigate occurrences of Toxoplasma gondii in pigs slaughtered with and without inspection service. Serum samples were collected from 60 pigs to detect anti-T. gondii antibody by indirect fluorescent antibody (IFAT). Tongue, masseter and diaphragm fragments were also collected for parasite DNA detection by means of the polymerase chain reaction (PCR) and histopathological analysis. The serological results showed that 77% (44/60) of the pigs were positive. Regarding PCR, 66.67% (40/60) were positive for T. gondii. Among the tissues evaluated, the diaphragm was the one with the highest frequency of positivity (40%; 24/60), followed by the masseter (38.33%; 23/60) and tongue (33.3%; 20/60). Histopathological changes were only observed in the diaphragm, which presented inflammatory infiltrates of lymphohistiocytic and neutrophilic types. These results not only show the potential threat of T. gondii to human health, but also demonstrate the dynamic epidemiological situation of toxoplasmosis in pigs in the city of São Luís, providing support for food security regarding pigs and for T. gondii control programs in Brazil.
Spudcan–pile interaction in sand-over-clay: centrifuge modelling
Authors: Falcon Sen Sven D. , Choo Yun Wook , Leung Chun Fai
Published: November 2021

Large soil movements arising from the installation of jack-up spudcan foundations may induce detrimental effects on piles supporting adjacent permanent jacket platforms. Particularly, in a dense sand-over-clay profile, there is a risk of spudcan rapid penetration due to underlying clay bearing capacity failure, known as spudcan punch-through failure, which can cause further damage to piles in the proximity. This study investigates the foundation interaction between the spudcan and adjacent pile in a sand-overlying-clay soil profile by way of centrifuge modelling. Issues investigated include thickness of the upper sand layer with incidence of sand plug beneath the spudcan and spudcan–pile clearance. The experimental findings reveal that spudcan punch-through hazard and the magnitude of induced pile moments amplifies primarily due to the increase in the thickness of the upper sand. In addition, the magnitude of induced pile moment in a sand-over-clay profile is significantly higher than that in a single clay profile because of the post-peak bearing behaviour observed in stratified soil, yielding to a greater risk to pile integrity. Soil pressure profiles on the piles are also back-analysed. Two generalised induced soil pressure profiles are deduced, with the first profile representing the onset of spudcan punch-through and the second profile denoting the situation of post-punch-through failure.
Bus bunching from a stop-based perspective: insights from visual analytics
Authors: Tsoi Ka Ho , Loo Becky P.Y.
Published: November 2021

Bus bunching can deteriorate bus service quality and jeopardise the effectiveness of public transit in promoting sustainable urban transport. This study applies artificial intelligence (AI) techniques in visual analytics to examine the spatiotemporal characteristics of bus bunching from a stop-based perspective. A total of 25 405 real-time traffic images were extracted and analysed from 11 bus stops in Hong Kong in August 2019 (7am–7pm, Tuesdays–Thursdays). An image classification model was developed with an overall accuracy of 85%. Three distinct groups were identified based on the spatiotemporal characteristics of bus bunching at different bus stops. They are (a) systematic peak hour, (b) minor and intermittent and (c) random bus bunching. Specific traffic conditions in terms of traffic speed, traffic composition and bus occupancy rate are highly associated with the onset of bus bunching. Overall traditional bus management tactics, such as schedule synchronisation and headways control, need to be supplemented by stop-based strategies that consider the temporal profiles of bus bunching and associated traffic conditions on road.
Emerging roles of sortilin in affecting the metabolism of glucose and lipid profiles
Authors: Su Xin , Chen Xiang , Wang Bin , Chen Linjian , Dai Cuilian
Published: November 2021

Dyslipidemia has recently been identified as an important factor in modulating the progression of several health conditions, grouped as cardio-metabolic syndrome and including obesity,insulin resistance, and atherosclerosis. Among multiple factors which regulate the development of cardio-metabolic syndrome, sortilin has been found in multiple cell types, such as adipocyte, hepatocyte, and macrophage, suggesting that sortilin is correlated to the development and the severity of cardio-metabolic syndrome. Consistently, several genome-wide association  (GWAS) and basic experimental research studies are being conducted to find novel gene loci involved in regulating the pathological progression of cardio-metabolic syndrome. According to these data, both SORT1 gene and sortilin protein have an important function in regulating the circulating lipid and glucose metabolism resulting in modulation of disease progression. In this comprehensive review, we summarize the recent research results in regards to sortilin function in modulating the circulating lipid and glucose metabolism. Moreover, we also discuss and analyze the emerging evidence elucidating the potential mechanisms by which sortilin affects synthesis and secretion of lipid and glucose.
The factors Related to Maternal-Fetal Attachment: Examining the Effect of Mindfulness, Stress and Symptoms during Pregnancy
Authors: Chien-Ming Tsao , Hung-Chun Hsing , Hsiu-Ho Wang , Sophie Huey-Ming Guo
Published: November 2021

Background: The development of a successful relationship between a mother and her developing fetus to foster maternal behavior attainment. Diverse factors such as psychophysiological elements influence the maternal-fetal relationship. Mindfulness, a psychological process, increasingly apples to the research of pregnant women’s wellbeing. However, most studies focus solely on physiological outcomes; few consider the maternal-fetal bonding. Purpose: This research aims to investigate whether factors of stress, symptoms during pregnancy and mindfulness systematically related to maternal-fetal attachment. Methods: Data were collected from 339 pregnant women, which were recruited from two hospitals in Taiwan, using the following questionnaires: the mindfulness scale, the symptom scale, the pregnancy stress scale during pregnancy, and the maternal fetal attachment scale. A path analysis approach was used to test the relationship. Results: Pregnancy stress is the most robust factor of maternal-fetal attachment. The mindfulness and stress during pregnancy both have significant direct effects on maternal-fetal attachment, ß = .46, and ß = 22, all p < 0.00, respectively. The mindfulness has a significant inverse, direct effect (ß = -.13, p < 0.05) on stress during pregnancy. But the variable of symptoms during pregnancy is no significant effect on maternal-fetal attachment. The model proposed in this study accounts for 22.5% (R2) variance in the relational model of maternal-fetal attachment. Conclusions: Given that the maternal mindfulness direct and indirect effect through stress variable on mother developing a closer connection with her babies, screenings of the relational elements should be incorporated into prenatal education programs.
Homotopy theory of Moore flows (II)
Authors: Gaucher Philippe
Published: November 2021

This paper proves that the q-model structures of Moore flows and of multipointed d-spaces are Quillen equivalent. The main step is the proof that the counit and unit maps of the Quillen adjunction are isomorphisms on the q-cofibrant objects (all objects are q-fibrant). As an application, we provide a new proof of the fact that the categorization functor from multipointed d-spaces to flows has a total left derived functor which induces a category equivalence between the homotopy categories. The new proof sheds light on the internal structure of the categorization functor which is neither a left adjoint nor a right adjoint. It is even possible to write an inverse up to homotopy of this functor using Moore flows.
Characterization of symplectic forms induced by some tangent G-structures of higher order
Authors: Kouotchop Wamba P.M. , Wankap Nono G.F.
Published: November 2021

Let (M, ω) be a symplectic manifold induced by an integrable G-structure P on M . In this paper, we characterize the symplectic manifolds induced by the tangent lifts of higher order r ≥ 1 of G-structure P, from M to TrM .
Abelmoschus esculentus yaprağı kullanılarak gümüş nanopartiküllerin yeşil sentezi ve bazı gıda patojenleri üzerindeki antimikrobiyal etkileri
Authors: HATİPOĞLU Abdulkerim
Published: November 2021

Bu çalışmada, Abelmoschus esculentus (AE) yaprağı özütü kullanılarak düşük maliyetli, çevre dostu ve kolay bir şekilde gümüş nanopartiküller (AgNP’ler) sentezlendi. Ultraviyole-görünür (UV-vis.) Spektrofotometre analiz verilerine göre, nanokristaller 431 nm'de karakteristik bir tepe noktası gösterdi. Taramalı Elektron Mikroskobu (SEM), Transmisyon Elektron Mikroskobu (TEM) ve enerji dağılımlı X-Işını Spektroskopisi (EDX) analizleri, biyolojik yolla sentezlenen AgNP'lerin morfolojik yapılarının küresel olduğunu ortaya koydu. XRD analizi sonuçlarına göre AgNP'lerin kristal yapılarının kübik olduğu görüldü. Nanopartiküllerin boyutu, Debye-Scherrer denklemi ile 19.05 nm olarak hesaplandı. Sentezlenen nanomalzemenin zeta potansiyeli -9.83 mV ve zeta boyutu da 142.2 nm olarak ölçüldü. AgNP'lerin, gıda patojenlerinden Staphylococcus aureus ATCC 29213, Escherichia coli ATCC25922, Bacillus subtilis ATCC11774, Pseudomonas aeruginosa ATCC27833 ve Candida albicans üzerindeki Minimum İnhibitör Konsantrasyonu (MİK) değerlerinin (mg/mL) sırasıyla 0.125, 0.50, 0.0312, 0.125 ve 0.125 düzeyinde olduğu tespit edildi.
Detecting reactive oxygen species in free-living symbiotic dinoflagellates exposed to nanoparticles v1
Authors: M M Roger Liza , Lewinski Nastassja
Published: November 2021

2',7'-dichlorodihydrofluorescein diacetate (DCFH-DA) is a popular fluorescent probe for the detection of oxidative stress in cells. Since the probe can be prone to auto-oxidation, carboxy-2',7'-dichlorodihydrofluorescein-diacetate (carboxy-H2DCF-DA) which is more stable and easily penetrates cell membranes is often reported in the literature instead. Upon crossing the cell membrane, esterases hydrolyse DCFH-DA to DCFH, which remains trapped within cells. The oxidation of DCFH yields DCF, a fluorescent compound which can be measured using excitation/emission wavelengths of 485-495/520-530 nm. Due to several cases of interference when used in cellular systems, DCFH-DA is a general marker of the cellular oxidative stress rather than a specific indicator H2O2 formation or other ROS.
Caught in the Crossfire: LGBT+ Traveller Intersectionality in Post-Brexit Britain
Authors: Eminson Regan John
Published: November 2021

This study aimed to investigate a gap in research regarding the contemporary experiences of individuals who identify as both LGBT+ and Traveller through an intersectional lens in post-Brexit Britain. To fully explore this issue three research questions were formulated; Question 1: What are the experiences of individuals that identify with the LGBT+ community and the Traveller community? Question 2: What are the perceptions of Travellers in the LGBTQ+ community? These questions were explored through both qualitative and quantitative data gathered by two online surveys, which consisted of responses from both LGBT+ Travellers and LGBT+ Non-Travellers who were recruited by the method of snowball sampling via social media, the quantitative data was analysed using descriptive statistics and the qualitative data was analysed using thematic coding. The results presented a negative experience for LGBT+ Travellers who felt the need to hide their identity and experienced discrimination in the identified theme of stereotyping in LGBT+ spaces. This research identified a lack of visibility of LGBT+ Traveller identity, in both Traveller and British society which has led to a negative impact upon this intersectional identity, predominantly causing an inability to authentically participate in either community.
Assessing the Impact of Community Centre’s on Roma Integration: A Study of Eastwood
Authors: Fuseini Olga
Published: November 2021

During the last 10 years, Roma have become the second largest and the most deprived ethnic minority in Rotherham and thus, the local authority has put Roma integration as a priority in terms of community planning and development. Due to the complexities around Roma integration and the government budget cuts to public spending, the local authorities rely on community centres to fill gaps in improving the Roma integration and their quality of life in the UK. This article aims to assess the impact of a community centre on Roma integration, specifically, focusing on the Eastwood area of Rotherham. The research methods included semi-structured interviews of professionals that regularly engage with Roma community and the Roma residents of Eastwood. The case study findings show that the Eastwood community centre plays a vital role in the Roma integration. Some of the main contributing factors include their expertise and the ability to effectively engage with the Roma community. However, this paper only touches upon the issue of Roma integration in the UK, which means that more comprehensive and a larger scale of research is needed to improve the processes of Roma integration and the integration of other communities in similar settings
DYNAMICS OF DEVELOPMENT OF LITHOFLUID OIL AND GAS SYSTEMS IN THE CRETACEOUS DEPOSITS OF THE WESTERN CENTRICLINAL OF THE BLACK SEA MEGADEPRESSION
Authors: Hryhorchuk K. , Hnidets V. , Wojcickyu Z.
Published: November 2021

On the basis of modeling the dynamics of the catagenesis of the Cretaceous deposits, the lateral heterogeneity of the history of their catagenesis within the western part of the Black Sea megadepression, caused by the tectonic regime of the blocks separated by the Golitsyn, Sulino-Tarkhankutsky, Gubkino-Donuzlavsky sublatitudinal faults, was established. The spatio-temporal features of the development of reservoirs and migration paths of hydrocarbon fluids have been established, the predicted zones of oil and gas accumulation have been localized. There are four types of lithogenetic reservoirs, which differed in the time of formation, structural features, fluid regime and the nature of oil and gas saturation.In the first cycle of catagenesis, the generation center was localized mainly in the sediments of the Lower Albian (t 80–100 оС), in the second – the Middle Albian (t 100–120 оС), in the third – the Upper Albian (t 130–150 оС).Given a certain difference in the situations of sedimentation of these stratigraphic units, the composition and content of scattered organic matter in the sediments were different. This, as well as the different generation temperatures, obviously caused the specific composition of hydrocarbon fluids formed during individual cycles of catagenesis. Along the migration pathways and during structural changes, these fluids were mixed, multicomponent systems were formed, and the composition of hydrocarbons changed.The possibility of the existence of subvertical "vein" areas of oil and gas accumulation with a width of up to 10 km and a height of 1,5–2,0 km is argued. Such reservoirs, on the one hand, may contain deposits and, on the other hand, supply hydrocarbons to overlying traps. Given the nature of oil and gas accumulation, the potential resources and, consequently, the prospects for oil and gas in the region can be much higher.
«Aging» of placenta
Authors: Ailamazyan Eduard K. , Kvetnoy Igor M. , Lapina Elena A.
Published: November 2021

As the nature of any intrinsic biologic aging process or even of its existence independent of disease is unknown, it is impossible to state whether or not the placenta gets old. There are two main conceptions to describe the morphological and physiological changes of placenta at term. It is widely believed that during the relatively short duration of normal pregnancy the placenta progressively ages and is, at term, on the verge of decline into morphological and physiological senescence. Several placental functions decrease near term, but it is impossible to attribute these to aging. In fact, some of them may represent adaptive additional maturation or pathological processes. The genetic differentiation/invasion/maturation programs of placental cells could be modulated by their environment: oxygen, extracellular matrix, and soluble factors (cytokines, growth factors, and hormones).
Pathogenesis of perinatal pathology in newborns developing under conditions of chronic hypoxia with placental insufficiency
Authors: Evsyukova I. I.
Published: November 2021

The study of the pathogenetic aspects of disorders in the formation of the functions of the central nervous system and other vital functional systems of the child's body under unfavorable conditions of its intrauterine development has always been a priority direction of scientific research by the employees of the Department of Physiology and Pathology of Newborns of the N.I. BEFORE. Otta RAMS.
Influence of relaxin and insulin on the activity of adenylate cyclase in the myometrium of pregnant women with type 1 diabetes mellitus
Authors: Kuznetsova L. A. , Plesneva S. A. , Shpakov Alexander O. , Pertseva Marina N. , Omelyanyuk Evgeniya V. , Bolotskikh V. M.
Published: November 2021

The study of the influence of relaxin and insulin on the activity of adenylate clase (AC) in the myometrium of pregnant women showed that human relaxin 2 (10-9-10-8 M) causes a stronger stimulating effect on the enzyme activity than insulin. The activating effect of relaxin and insulin was potentiated by a non-hydrolyzable GTP analogue, guanylylimidodiphosphate (GIDP), in the myometrium of pregnant women, which indicates the participation of the stimulating GTP-binding protein (Gs-protein) in the realization of the effect of peptides. In the myometrium of pregnant women with type 1 diabetes mellitus under the action of relaxin, insulin and isoproterenol, a decrease in the sensitivity of AC activity to these hormones was found in comparison with these indicators in the myometrium of pregnant women. With the combined effect of peptides and GIDP in the myometrium of pregnant women with type 1 diabetes mellitus, a weakening of the potentiation of the GIDP effect of hormones on AC activity was observed, which may indicate a decrease in the coupling between receptors, Gs protein, and AC. The studies carried out allow us to conclude that in pregnant women with type 1 diabetes mellitus, the decrease in AC stimulation under the influence of these hormones is associated with a weakening of the Gs-protein function.
Rationale for the use of the original classification of posttraumatic acetabular deformities in primary total hip replacement
Authors:   Vreden National Medical Research Center of Traumatology and Orthopedics, Saint Petersburg, Russian Federation, Tsybin A.V. , Lubchak V.V. ,   Vreden National Medical Research Center of Traumatology and Orthopedics, Saint Petersburg, Russian Federation, Sivkov V.S. ,   Vreden National Medical Research Center of Traumatology and Orthopedics, Saint Petersburg, Russian Federation, Shilnikov V.A. ,   Vreden National Medical Research Center of Traumatology and Orthopedics, Saint Petersburg, Russian Federation, Malygin R.V. ,   Vreden National Medical Research Center of Traumatology and Orthopedics, Saint Petersburg, Russian Federation, Shubnyakov M.I. ,   Vreden National Medical Research Center of Traumatology and Orthopedics, Saint Petersburg, Russian Federation
Published: November 2021

Abstract. Introduction Analysis of publications on primary hip replacement shows lower survival rates in patients with acetabular injuries. With the lack of a unified system for assessing post-traumatic acetabular deformities, authors tend to use the available classifications of acute pelvic trauma (AO/ ASIF, Young & Burgess, Tile, etc.) and acetabular osteolysis (AAOS, DGOT, Gross and Saleh, Paprosky), which we think can be inappropriate with the classifying systems meant for different patterns of acetabular deficiency. Material and methods CT scans of 117 patients with posttraumatic acetabular deformities were reviewed prior to total hip replacement (THR) performed for posttraumatic grade III coxarthrosis. The displacement of acetabular walls was determined with the measurements tabulated and analyzed. Results An original "ASPID" classification of post-traumatic deformities based on the findings obtained was offered with use of three assessment criteria: localization of the deformity, extent of displacement and the integrity of the pelvic ring. The ASPID classification can be used for the localization of the deformity with anterior (A), superior (S), posterior (P) and inner acetabular walls (I) to be identified. Measurements of displacement ranging 0-5 mm suggests grade 0 displacement; 6-15 mm, grade 1 displacement and greater than 15 mm, grade 2 displacement. The integrity of the pelvic ring evaluated from the involvement side as D0 suggests maintained pelvic integrity and D1, broken pelvic integrity. An acetabular hardware would be marked with 'H'. Conclusion ASPID classification is easy to use and has shown to be practical for planning of primary THR after acetabular fracture.
Hematological parameters of rheumatoid arthritis patients undergoing total hip replacement
Authors:   Ural State Medical University, Ekaterinburg, Russian Federation, Ershov A.S. ,   Sverdlovsk Regional Clinical Hospital No. 1, Ekaterinburg, Russian Federation, Antropova I.P. ,   Ural State Medical University, Ekaterinburg, Russian Federation,   Institute of High Temperature Electrochemistry of the Ural Branch of the Russian Academy of Science, Ekaterinburg, Russian Federation, Volokitina E.A. ,   Ural State Medical University, Ekaterinburg, Russian Federation, Evstigneeva L.P. ,   Ural State Medical University, Ekaterinburg, Russian Federation,   Sverdlovsk Regional Clinical Hospital No. 1, Ekaterinburg, Russian Federation
Published: November 2021

(THR). Inflammation in RA is the main factor manifesting anaemia, neutropenia, thrombocytosis and eosinophilia. The changes in blood components are important for the outcomes of major orthopaedic surgery. The purpose was to identify hematological parameters in RA patients undergoing THR and assess the effect on intraoperative blood loss. Material and methods Outcomes of 44 THR patients treated for grade III degenerative coxarthrosis (n = 21, OA group) and RA coxarthrosis (n = 23, RA group) in Ekaterinburg regional hospital № 1 between 2018 and 2019 were reviewed. The patients' age ranged from 41 to 70 years. Clinical, radiological, laboratory examinations, computed tomography and statistical analysis were used for the study. Cell counting was produced with the Sysmex XT-4000i automated hematology system. Statistical analysis was performed using the tools of Statistica software. Nonparametric Mann-Whitney test was used to compare cell counts between the groups. The Spearman Rank correlation was used to analyse the correlation between the the cell counts in the groups. For calculations, a significance level of р < 0.05 was adopted. Results There were no significant differences in the preoperative white blood cell (WBC), neutrophil, lymphocyte, monocyte, eosinophil counts between RA and OA groups. The RA group showed an evident decrease in red blood cell (RBC) count and haemoglobin level as compared to OA group. The RA group demonstrated the higher platelet count with mean platelet volume (MPV) being significantly lower than that in the OA group. WBC count, neutrophils, in particular, was shown to increase with lymphocyte, RBC, platelet count and hemoglobin, plateletcrit levels decreased at 24 hours postoperatively. There were no significant differences in WBC and RBC counts in the groups postoperatively. The differences in the MPV were leveled up in the groups with the platelet count being higher in the RA group as compared to the OA group. Conclusions Hematological parameters of RA patients who had undergone specific preoperative preparation were not shown to be associated with greater blood loss during hip replacement surgery. The leukocyte count leveled up in the preoperative and early postoperative periods can be indicative of the absence of a significant effect of RA on the postoperative inflammation.
Survival analysis of the femoral component retained in isolated acetabular revision of the hip prosthesis
Authors:   Saratov Razumovsky State Medical University, Saratov, Russian Federation, Zvereva K.P , Ostrovskiy V.V. ,   Saratov Razumovsky State Medical University, Saratov, Russian Federation, Markov D.A. ,   Saratov Razumovsky State Medical University, Saratov, Russian Federation, Sertakova A.V. ,   Saratov Razumovsky State Medical University, Saratov, Russian Federation, Reshetnikov A.N. ,   Saratov Razumovsky State Medical University, Saratov, Russian Federation
Published: November 2021

Abstract. Introduction Isolated acetabular revision with the retention of a well-fixed and aligned femoral component is the priority treatment method in aseptic acetabular loosening. The aim of the research was to predict the survival rate of a well-fixed and aligned femoral component retained during the isolated acetabular revision surgery. Material and methods We used the survival tables and the Kaplan-Meier method to create the survival curves. The object of the study was the database of 44 patients (45 interventions) who underwent isolated acetabular revision surgeries with their well-fixed and aligned femoral components that was retained. The average age of the patients was 59.5 [50; 69.5] years. The ratio of women to men was 25:19, respectively. The observation period was 1374 days. The creation of tables and graphs was carried out in Statistica 13.3 software package. Results The survival rate of the retained well-fixed and aligned femoral component in isolated acetabular revision within the period up to 4 years was high and amounted to 0.9524 ± 0.03. The probability density and the hazard rates were 0.0017 and 0.00320, respectively. Discussion The retention of a well-fixed and aligned stem in acetabular revision features high survival of the components as well as a low risk of endoprosthesis failure within 3 to 4 years. This fact confirms the need to maintain a stable and correctly oriented stem to reduce the surgical trauma, obtain good functional results and reduce rehabilitation terms. Conclusion Isolated acetabular revision in isolated aseptic cup loosening is a priority method of surgical treatment with a low risk of complications in the postoperative period.
Two-stage treatment of hip periprosthetic joint infection complicated with retroperitoneal urinary bladder defect
Authors:   Rostov Regional Clinical Hospital No. 2, Rostov-on-Don, Russian Federation, Ivanian S.T. , Basov S.V. ,   Rostov Regional Clinical Hospital No. 2, Rostov-on-Don, Russian Federation, Gritsuk N.O. ,   Rostov Regional Clinical Hospital No. 2, Rostov-on-Don, Russian Federation, Pronin V.A. ,   Rostov Regional Clinical Hospital No. 2, Rostov-on-Don, Russian Federation, Tikhonenko S.N. ,   Rostov City Emergency Hospital, Rostov-on-Don, Russian Federation
Published: November 2021

emphasize the importance of preoperative preparation and well-coordinated work of related specialists using a specific clinical instance. Case report Reported is a successful experience of two-stage treatment of the patient with hip PJI complicated with urinary bladder defect. A 40-year old male patient diagnosed with left-sided deep hip PJI Tsukayama type 3 was treated at department of infection surgery, Rostov Regional Clinical Hospital No. 2 in January 2019. Total hip arthroplasty performed in 2008 was complicated by migration of acetabulum component. A retroperitoneal bladder defect (pressure ulcer) was detected during the first stage of resection arthroplasty and placement of an antibacterial spacer. Urological procedure was performed in a delayed manner due to technical difficulties of implant removal, prolonged and traumatic procedure, and high blood loss. With the patient's condition stabilized cystoscopy and bilateral ultrasound guided percutaneous nephroureterostomy were performed. Prolonged antibacterial aetiotropic treatment was administered. The second stage of surgical treatment included revision hip arthroplasty using a tailored acetabular component and a standard revision femoral component performed at 6 months of debridement. Results Short- and long-term results were good with sustained remission achieved. Patient could walk unassisted using a cane and had a satisfactory ROM in the left hip with HHS scored 76.255. Conclusion Multiple disciplinary teamwork is appropriate for treatment of deep PJI with much coherence, coordinated efforts and expertise from diverse professionals.
Viajes de cuidado en bicicleta en cuatro localidades de Bogotá
Authors: Pipicano Wilmer , Peña Andrés Javier , Pipicano Christian , Fernández María Andrea , Porras Isabela , Arias Néstor , Miranda Leonel
Published: November 2021

Transportar niñas y niños al colegio como pasajeros en bicicleta es una alternativa que los adultos, y en especial las madres, adoptan, por la flexibilidad y economía de este modo de desplazamiento. En los últimos años, Bogotá ha liderado una estrategia activa para convertirse en la capital de la bicicleta, con una agenda amplia para incrementar el número de mujeres usuarias de este modo de transporte. Adicionalmente, luego de la pandemia del COVID-19, se ha dado la oportunidad de promocionar el uso de la bicicleta como un medio de transporte sustentable, cómodo y con menor riesgo de contagio. La Secretaría Distrital de Movilidad junto con la Secretaría Distrital de la Mujer y con el apoyo del Transport Gender Lab del Banco Interamericano de Desarrollo, a través de la firma Movilidad Sostenible Ltda., realizó un estudio exploratorio en colegios públicos de cuatro localidades de Bogotá, donde se ha observado la mayor demanda de viajes en bicicleta. El estudio identifica las motivaciones asociadas a los viajes realizados en bicicleta en los que se transportan niñas y niños como pasajeros, que permita la generación de una estrategia con enfoque de género para mejorar la seguridad vial, la calidad de viaje y la intermodalidad con el Sistema de Transporte Público Masivo para estos actores.