bluuebunny/crossref_metadata_2025 huggingface dataset:
Real-Time Air-to-Ground Data Communication Technology of Aeroengine Health Management System with Adaptive Rate in the Whole Airspace
Authors: Yan Qiuying , Li Wei , Li Jiacheng , Zhang Jie , Liu Shengyi , Wang Zhe , Liu Tong , Chen Qian , Sheng Hanlin
Published: August 2021

To overcome the problem of data transmission of the aeroengine health management system, a multilink communication system combining ultrahigh-frequency communication link, 4G cellular mobile communication link, and BeiDou satellite communication link was proposed. This system can realize the functions such as data receiving and sending, data encryption, and resuming transfer from the break point based on multiple links. When the flight altitude is not high, the communication distance is short, so the UHF digital transmission radio communication link is adopted, which is highly efficient and stable. When the communication distance is long, the 4G cellular mobile communication link can ensure both the communication distance and the communication rate. In the area where 4G signal cannot be covered in extreme terrain environment, BeiDou satellite communication link is used for data transmission. Besides, in order to ensure the communication rate of the link, a multilink adaptive switching technology was also developed. The test verified that the system can perform adaptive switching among multiple links, realize air-ground data communication in the whole airspace, and achieve a good communication rate, which has significative value of engineering application.
Deployment of Clustered‐Based Small Cells in Interference‐Limited Dense Scenarios: Analysis, Design, and Trade‐Offs
Authors: Urquiza Villalonga David Alejandro , Riera-Palou Felip , Fernández-Getino García M. Julia , Femenias Guillem
Published: August 2021

Network densification is one of the most promising solutions to address the high data rate demands in 5G and beyond (B5G) wireless networks while ensuring an overall adequate quality of service. In this scenario, most users experience significant interference levels from neighbouring mobile stations (MSs) and access points (APs) making the use of advanced interference management techniques mandatory. Clustered interference alignment (IA) has been widely proposed to manage the interference in densely deployed scenarios with a large number of users. Nonetheless, the setups considered in previous works are still far from the densification levels envisaged for 5G/B5G networks that are considered in this paper. Moreover, prior designs of clustered‐IA systems relied on oversimplified channel models and/or enforced single‐stream transmission. In this paper, we explore an ultradense deployment of small cells (SCs) to provide coverage in 5G/B5G wireless networks. A novel cluster design based on a size‐restricted k‐means algorithm to divide the SCs into different clusters is proposed taking into account path loss and shadowing effects, thus providing a more realistic solution than those available in the current literature. Unlike previous works, this clustering method can also cater for spatial multiplexing scenarios. Also, several design parameters such as the number of transmit antennas, multiplexed data streams, and deployed APs are analyzed in order to identify trade‐offs between performance and complexity. The relationship between density of network elements per area unit and performance is investigated, thus allowing to illustrate that there is an optimal coverage area value over which the network resources should be distributed. Moreover, it is shown that the spectral‐efficiency degradation due to the intercluster interference in ultradense networks (UDNs) points to the need of designing an interference management algorithm that accounts for both intracluster and intercluster interferences. Simulation results provide key insights for the deployment of small cells in interference‐limited dense scenarios.
A Study of the Anisotropic Static Elasticity System in Thin Domain
Authors: Letoufa Yassine , Boulaaras Salah Mahmoud , Benseridi Hamid , Dilmi Mourad , Alharbi Asma
Published: August 2021

We study the asymptotic behavior of solutions of the anisotropic heterogeneous linearized elasticity system in thin domain of

ℝ

3

which has a fixed cross-section in the

ℝ

2

plane with Tresca friction condition. The novelty here is that stress tensor has given by the most general form of Hooke’s law for anisotropic materials. We prove the convergence theorems for the transition 3D-2D when one dimension of the domain tends to zero. The necessary mathematical framework and (2D) equation model with a specific weak form of the Reynolds equation are determined. Finally, the properties of solution of the limit problem are given, in which it is confirmed that the limit problem is well defined.
Condition-Specific Molecular Network Analysis Revealed That Flagellar Proteins Are Involved in Electron Transfer Processes of Shewanella piezotolerans WP3
Authors: Ding Dewu , Wang Meineng , Wu Meili , Gan Chengzhi , Wu Pu
Published: August 2021

Because of the ability to metabolize a large number of electron acceptors such as nitrate, nitrite, fumarate, and metal oxides, Shewanella species have attracted much attention in recent years. Generally, the use of these electron acceptors is mainly achieved through electron transfer proteins and their interactions which will dynamically change across different environmental conditions in cells. Therefore, functional analysis of condition-specific molecular networks can reveal biological information on electron transfer processes. By integrating expression data and molecular networks, we constructed condition-specific molecular networks for Shewanella piezotolerans WP3. We then identified condition-specific key genes and studied their potential functions with an emphasis on their roles in electron transfer processes. Functional module analysis showed that different flagellar assembly modules appeared under these conditions and suggested that flagellar proteins are important for these conditions. We also identified the electron transfer modules underlying these various environmental conditions. The present results could help with screening electron transfer genes and understanding electron transfer processes under various environmental conditions for the Shewanella species.
An Analysis of the Gear Meshing Characteristics of the Main Planetary Gear Trains of Helicopters Undergoing Shafting Position Changes
Authors: Xuejun Li , Lingli Jiang , Dengrong Hua , Daoxuan Yin , Dalian Yang
Published: August 2021

The complex three-shaft three-reducer structural designs of helicopter transmission systems are prone to changes in the relative positions of shafting under the conditions of main rotor and tail rotor loads. These changes will affect the transmission characteristics of the entire transmission system. In this study, the planetary gear trains of helicopters were examined. Due to the fact that these structures are considered to be the most representative structures of the main reducers of helicopters, they were selected as the study objects for the purpose of examining the meshing characteristics of planetary gear trains when the relative positions of the shafting changed due to the position changes of the main rotor shafts under variable load conditions. It was found that by embedding the comprehensive time-varying meshing stiffness values of the main rotor shafts at different positions, a dynamic model of the relative position changes of the planetary gear trains could be established. Then, combined with the multibody dynamics software, the meshing characteristics of the sun gears, and the planetary gears, the planetary gears and the inner ring gears were simulated and analyzed under different inclinations and offsets of the shafting. The results obtained in this study revealed the following: (1) the average meshing force of the gears increased with the increases in the angle inclinations, and the meshing force between the sun gears and the planetary gears increased faster than the meshing force between the planetary gears and the inner ring gears. It was observed that during the changes in the shafting tilt positions, obvious side frequency signals had appeared around the peak of the meshing frequency in the spectrum. Then, with the continuous increases in the tilt position, the peak was gradually submerged; (2) the average meshing force of the gears increased with the increases in the offset, and the increasing trend of the meshing force between the sun gears and the planetary gears was similar to that observed between the planetary gears and the inner ring gears. It was found that when the shafting offset position changed, there were obvious first and second frequency doubling in the spectrum; (3) the mass center orbit radii of the sun gears increased with the increases in the shafting position changes, and the changes in the angular tilt position were found to have greater influencing effects on the mass center orbit radii of the sun gears than the changes in the offset positions. This study’s research findings will provide a theoretical basis for future operational status monitoring of the main transmission systems of helicopters and are of major significance for improvements in the operational stability of helicopter transmission systems, which will potentially ensure safe and efficient operations.
Numerical Simulation of Surface Movement and Deformation Caused by Underground Mining with Complex Stratigraphic Boundary
Authors: Wang Liang , He Chao , Cui Songjun , Wang Feifei
Published: August 2021

The interface program of finite element software based on surface spline interpolation is developed by using MATLAB software. The controllable 3D surface modeling based on CAD contour is realized. Taking a mine as an example, the method of establishing the 3D numerical calculation model including complex stratum boundary is studied. The influence of underground mining on surface movement and deformation under complex stratum conditions by using the FLAC3D software further was discussed. The research results show that the developed interface program of finite element software can well realize the numerical modeling of complex formation and provide help for subsequent numerical simulation. The calculated subsidence value is in good agreement with the measured value. The values of surface tilt, surface curvature, and surface horizontal deformation are less than the relevant regulations. The mining method of the filling method has no obvious effect on the surface structures. The research results can provide reference for similar numerical simulation.
Wideband Crescent-Shaped Slotted Printed Antenna with Radiant Circular Polarisation
Authors: Asmeida Akrem , Abidin Zuhairiah Zainal , Mohd Shah Shaharil , Kamarudin Muhammad Ramlee , Malek Norun Abdul , Nebhen Jamel
Published: August 2021

Producing a suitable impedance matching between the radiating element and the feedline is the prior hurdle to overcome for a wideband antenna with circular polarisation designs. This study presents a novel antenna consisting of a defected ground structure (DGS) and a crescent-slot radiating patch for broad impedance bandwidth. In addition, a narrow rectangular slot was etched on the ground plane for antenna compactness and outcomes improvement. In order to examine the reliability, two different numerical softwares were compared based on the antenna’s basic structure. Apart from this, an equivalent circuit of the proposed prototype is modelled logically using ADS 2016. The numerical results demonstrate that the impedance bandwidth was about 74.6% for < −10 dB, while the 3 dB axial ratio bandwidth greater than 53% was achieved. In the operational bandwidth of the design, good impedance matching and high efficiency were seen, which shows that this design is appropriate for modern wireless communication systems in ISM and GSM bands.
Study of the Effect of Pretreatment of Corms by Different Concentrations of Gibberellic Acid and at Different Periods on the Growth, Flowering, and Quality of Saffron in Eastern Morocco
Authors: Mzabri Ibtissam , Rimani Maria , Kouddane Noureddine , Berrichi Abdelbasset
Published: August 2021

The present study was conducted to evaluate the influence of gibberellic acid (25, 50, 100, and 200 ppm) applied on saffron corms previously harvested during different periods (March, June, and before planting) on the growth and the quantitative and qualitative yield of saffron (Crocus sativus L.). The study was carried out in the field during the 2016-2017 and 2017-2018 seasons in the experimental station of the Faculty of Sciences of Oujda (Morocco). The measured parameters correspond, on the one hand, to morphometric measurements and to the determination of the saffron stigma yield and, on the other hand, to the evaluation of the quality of the spice. The results showed that almost all the parameters studied were significantly affected by the factors considered. The treatment of corms just before planting with concentrations of 100 and 200 ppm GA3 showed the highest flower and leaf appearance rate and the highest leaf length and surface area. Moreover, the application of GA3 during the month of March gave the best results in terms of stigmata yield, percentage of large-diameter daughter corms, and the ratio of the number of flowers produced to the total weight of corms. The results of the coefficient of corm propagation revealed that the application of gibberellin during any period improved this coefficient compared to the control. The results indicated that the application of GA3 with concentrations above 25 ppm can improve the growth of saffron and increase its yield under the semiarid climatic conditions of eastern Morocco.
How to Use Advanced Fleet Management System to Promote Energy Saving in Transportation: A Survey of Drivers’ Awareness of Fuel-Saving Factors
Authors: Zhang Changjian , He Jie , Bai Chunguang , Yan Xintong , Gong Jian , Zhang Hao
Published: August 2021

Despite the broad application of advanced fleet management systems (FMSs) in third-party logistics (3PL) companies, there is a marginally limited understanding of how to employ them to enhance transport energy efficiency. In a case study of a Chinese 3PL company, this paper analyzed data obtained from the online FMS to assess drivers’ awareness of fuel-saving factors. A questionnaire was primarily designed to investigate the drivers’ awareness of fuel-saving factors based on the reliability and validity test. Then, Extreme Gradient Boosting (XGBoost), a machine learning algorithm, was utilized to explore the intrinsic impacts of various factors on fuel consumption with the outputs providing the evaluation basis for individual awareness of the drivers. The results show a significant deviation in the driver’s awareness of fuel-saving factors, among which the three indicators of engine speed, idling condition, and rolling without engine load are seriously underestimated, while the indicators related to the environment are seriously overestimated due to social expectations. In addition, the average speed was found to be the most important fuel-saving indicator besides the load. Based on these findings, this paper recommends that the 3PL companies choose a route with more freeways when planning, and the mileage should be controlled within 800 km as far as possible.
[Retracted] Effects of Ulinastatin on Proliferation and Apoptosis of Breast Cancer Cells by Inhibiting the ERK Signaling Pathway
Authors: Xing Zeyu , Wang Xin , Liu Jiaqi , Liu Gang , Zhang Menglu , Feng Kexin , Wang Xiang
Published: August 2021

Purpose. To explore the effects of ulinastatin on the proliferation and apoptosis of breast cancer cells and the relevant mechanism of action. Methods. Breast cancer cells (MCF‐7) were cultured and randomly divided into three groups, namely, control group, ulinastatin group, and ulinastatin+extracellular‐regulated protein kinase (ERK) inhibitor group. Then, the Cell Counting Kit‐8 (CCK‐8) assay was carried out to detect the effect of ulinastatin on the viability of breast cancer cells. The effects of ulinastatin on the proliferation and apoptosis of breast cancer cells were determined via EdU staining and Hoechst 33258 staining assays, respectively. The messenger ribonucleic acid (mRNA) and protein expression levels of ERK and forkhead box O3 (FOXO3) in breast cancer cells were measured through reverse transcription‐polymerase chain reaction (RT‐PCR) and Western blotting. Results. In comparison with the control group, the ulinastatin group displayed decreased viability of breast cancer cells, a decreased positive rate of 5‐ethynyl‐2 ′‐deoxyuridine (EdU) staining, an increased positive rate of Hoechst 33258 staining, and reduced mRNA and protein levels of ERK and FOXO3 in breast cancer cells. Compared with those in the ulinastatin group, the viability of breast cancer cells was lowered, the positive rate of EdU staining was reduced, the positive rate of Hoechst 33258 staining was raised, and the mRNA and protein levels of ERK and FOXO3 in breast cancer cells clearly declined in the ulinastatin+ERK inhibitor group. Conclusion. Ulinastatin inhibits the proliferation and promotes the apoptosis of breast cancer cells. The possible mechanism of action is associated with the suppression of the ERK signaling pathway.
Generaciones centenial y milenial: actitudes hacia la sexualidad
Authors: Barragán Pérez Virginia , Fouilloux Morales Claudia
Published: August 2021

(analítico)El objetivo general fue conocer las actitudes hacia la sexualidad de estudiantes universitarios de las generaciones milenial y centenial. Como objetivo específico se validó un cuestionario de actitudes. Se siguió una metodología no experimental, transversal, con análisis descriptivo de respuestas de 402 estudiantes (69.1 % mujeres, 30.9 % hombres), con una media de edad de 20.8 años (DE 2.07). Resultaron actitudes favorables hacia: expresiones sexuales homosexuales y transexuales, eliminación de roles de género, uso del condón y rechazo hacia la violencia en redes sociales. Se presentaron actitudes desfavorables hacia el amor y actitudes indecisas hacia las relaciones casuales. Concluimos que el conocimiento de las actitudes es fundamental en el diseño y la ejecución de políticas de salud pública dirigidas a promover y preservar la salud sexual de las generaciones actuales.
Palabras clave: Sexualidad, actitudes, estudiantes universitarios, diferencias generacionales, propiedades psicométricas. Tesauro Eric.
Print Culture and Sufi Modernity: Al-Tuhāmī al-Wazzānī’s Embodied Reading of Morocco’s Nahḍa
Authors: Head Gretchen
Published: August 2021

Rethinking Arabic literary modernity, this article addresses what the act of reading means as Morocco moves from manuscript to print. In 1941, a leading figure of Morocco’s nahḍa, al-Tuhāmī al-Wazzānī, began to serialize his autobiography al-Zāwiya in one of the country’s earliest newspapers. Heralded as Morocco’s first novel, the moment marks the inauguration of a new reading public. Yet the text does not rely upon the reconfigured relationship with the reader accompanying the rise of print cultures in much of the Middle East and North Africa. Al-Zāwiya is a Sufi autobiography, a genre that invites its readers to assimilate the actions found within its pages. Al-Wazzānī draws upon this long tradition, using intertextual engagement to create a space of discourse that complicates the presumed secularity of Arabic literature during the nahḍa. Early Moroccan print culture thus provides an opportunity to reconsider the continuities of tradition embedded within modern literary practices.
The Limbu Script and the Production of Religious Books in Nepal
Authors: Gaenszle Martin
Published: August 2021

With the rise of ethnic politics in Nepal, the Limbu (or: Yakthumba) have made increasing use of the Limbu script, also known as Srijanga or Kiranti. Whereas in the past this script was suppressed by the state and known only to a minority, since the return of democracy to Nepal in the 1990s a new literature using this script has come into being. Here, religious books play a prominent role. This essay deals with the emerging importance of the script as a marker of ethnicity since its first general propagation by Iman Singh Chemjong and Phalgunanda Lingden in the early twentieth century. It focuses on the early production of printed books, in particular books published by followers of the Satyahangma movement, which promotes reforms of Kiranti religion and society.
Early Hindu Sectarian Printed Books: An Analysis of a Tamil Library
Authors: Weiss Richard S.
Published: August 2021

On a trip to South India in the early 1850s, the German missionary Karl Graul collected a library of Tamil books. His library contains some of the first books that Tamils edited and published for Tamil audiences. This article analyses the Shaiva and Vaishnava works in this collection, arguing that in this early period of Tamil publishing, Tamil Hindus turned to print in part to counter Christian evangelisation. They edited and published texts previously transmitted on manuscripts, in order to build a corpus of Shaiva and Vaishnava printed books that would challenge the Christian monopoly of Tamil print. The article focuses on the editing activities and institutional affiliations of Tamil Shaiva editors, most importantly the prominent scholar Vedagiri Mudaliyar.
Vision, Worship, and the Transmutation of the Vedas into Sacred Scripture. The Publication of Bhagavān Vedaḥ in 1970
Authors: Larios Borayin
Published: August 2021

This article discusses the first Indian compilation of the four Vedic Saṃhitās into a printed book in the year 1971 entitled “Bhagavān Vedaḥ.” This endeavor was the life’s mission of an udāsīn ascetic called Guru Gaṅgeśvarānand Mahārāj (1881–1992) who in the year 1968 founded the “Gaṅgeśvar Caturved Sansthān” in Bombay and appointed one of his main disciples, Svāmī Ānand Bhāskarānand, to oversee the publication of the book. His main motivation was to have a physical representation of the Vedas for Hindus to be able to have the darśana (auspicious sight) of the Vedas and worship them in book form. This contribution explores the institutions and individuals involved in the editorial work and its dissemination, and zooms into the processes that allowed for the transition from orality to print culture, and ultimately what it means when the Vedas are materialized into “the book of the Hindus.”
Heterodox Philology: A Conversation with Gauri Viswanathan
Authors: Allan Michael
Published: August 2021

Michael Allan and Gauri Viswanathan discuss connections among philology, literary history, and religion, drawing from writers such as Edward Said, B.R. Ambedkar, Zora Neale Hurston, Louis Massignon, and Kumud Pawde. The conversation was initially conducted via Zoom on September 2, 2020, and collaboratively edited for readability.
Printing the Goddess: Intersections of Language, Place, Technology, and Agents of Transmission in Nepali Manuscript and Early Print Culture
Authors: Birkenholtz Jessica Vantine
Published: August 2021

In late nineteenth-century Nepal, the advent of print and mass reproduction marked a critical and as yet understudied junction in Nepal’s literary history and attendant manuscript and print cultures. This article employs Nepal’s popular Svasthānīvratakathā to illuminate key shifts and intersections between language of composition, technologies of writing, places of composition or reproduction, and the agents of transmission that are emblematic of local manuscript practices and paradigmatic of the emergent print culture in late nineteenth- and early twentieth-century Nepal. The practices and actors involved in Svasthānī transmission shifted the text away from the private, domestic sphere to the public, translocal realm on multiple levels. Attending to these shifts as evidenced in one living devotional tradition indexes significant developments and intersections that deepen our knowledge of the changing linguistic, technological, geocultural, and socioeconomic aspects of the literary landscape in Nepal and South Asia more broadly.
Print Cultures in the Making in 19th- and 20th-Century South Asia: Beyond Disciplinary Boundaries
Authors: Pecchia Cristina , Buss Johanna , Chudal Alaka A.
Published: August 2021

The study of the history of print technology in South Asia is a multidisciplinary enterprise which involves attentive consideration of the cultural and linguistic diversity of the region, as well as of the historical time in which print technology was massively adopted, namely the colonial period. Here, we focus on the complex fabric of relationships between print and modes of recording and using texts in long present oral and manuscript cultures, also pointing out the limits of applying interpretative models based on the cultural history of Europe to the histories of print in South Asia. Furthermore, we present aspects of the formative stage of print cultures concerning Vedic, Limbu, Nepali, Newari, and Tamil textual traditions—which are studied in the essays of this special issue. This multi-layered perspective helps making sense of social and cultural dynamics concerning the uses of printed books, the (new) meanings associated with them, and the formation of hegemonic configurations within literary and religious traditions.
Modern Nepali Oral Transmissions of Vetālapañcaviṃśati Stories to Europe
Authors: Chudal Alaka Atreya
Published: August 2021

This article presents three recitation versions of two tales from the famous Vetālapañcaviṃśati (VP; the “Twenty-Five Tales of an Animated Corpse”, a medieval Sanskrit anthology of riddle-tales) that made their way orally from South Asia to Europe. The original work is one of the rare Sanskrit texts to have been disseminated widely and over a long period of time. It is a work that has thrived in oral, manuscript and printed versions. The stories in question, recorded in Germany as retold by three Nepali prisoners of war during World War I, show how this pre-modern Indian textual tradition was received into modern vernaculars and recounted in modern settings. It documents the fluidity of texts as dependent on the reciter’s, scribe’s or publisher’s own outlook, as well as on differing times and circumstances. In addition to the text’s long history of transmission, colonialism and print capitalism were further factors that influenced the retelling of the VP.
Nepali Intellectuals in Exile: The History of Nepali Printing in 19th- and 20th-Century Benares
Authors: Chudal Alaka Atreya
Published: August 2021

Restrictions on the freedom of speech and press, along with the unavailability of competitive printing solutions in Nepal under the Rana regime, caused the centre of gravity of scholarly activities to shift to India. A number of Nepali intellectuals, who came from a variety of backgrounds and had various reasons for having migrated to India, were involved in writing and publishing starting by the end of the 19th century. In those days Benares had few if any peers among Indian cities as a centre of local traditions of education and Sanskrit learning, and as a spiritual, economic and literary destination for Nepalis. Benares, which occupies a special place in Nepali history for its immense contribution to the country’s cultural, social, literary and political evolution, was also the main hub of Nepali print entrepreneurs. This article will delve into early such entrepreneurs and an array of Nepali printing activities in Benares before 1950.
Literature in Layers: An Early Theory of Retelling the Sanskrit Epics
Authors: Hawley Nell Shapiro
Published: August 2021

This essay reconstructs an early chapter in the history of theorizing the diverse Rāmāyaṇa and Mahābhārata literature of South Asia. Drawing upon the tenth-century literary theorist Kuntaka’s discussions of the Udāttarāghava, Uttararāmacarita, Veṇīsaṃhāra, Kirātārjunīya, and Abhijñānaśākuntala—all Sanskrit poetic (kāvya) compositions that depict stories from the Rāmāyaṇa or the Mahābhārata—I show how, in Kuntaka’s understanding, these works repair certain narrative inconsistencies and ethical ambiguities in the epics themselves. Building on the foundation laid by his predecessor, Ānandavardhana, Kuntaka illuminates the various layers of meaning that a work of literature can encompass. He shows that the epics’ different narrative layers send conflicting messages about proper conduct. He suggests, moreover, that an audience experiences a kāvya retelling of an epic story as a layered entity—a layer of epic narrative beneath a layer of kāvya—and argues that an awareness of these layers can contribute to the audience’s ethical self-cultivation. Kuntaka’s theory of retelling (truly re-telling: telling again, purposefully, and differently from a previous accepted telling) represents an important theoretical account of the relationships between South Asia’s many Rāmāyaṇas and many Mahābhāratas.
Persian Treatises on Āyurveda: The Shaping of a Genre
Authors: Speziale Fabrizio
Published: August 2021

This article examines the translation of foreign materials into post-Abbasid Muslim medical culture by looking at the production of Persian works dealing with Ayurvedic medicine. From the 14th century onwards, the composition of Persian texts on Āyurveda emerged in South Asia as a new genre of writing, which was actually a composite genre including various kinds of texts. The Muslim physicians incorporate the other’s learning not by rejecting the principles of their receiving culture but rather by empirically applying the logic of their principles in understanding the foreign environment and the receiving culture. The composition of new texts on Āyurveda in Persian constitutes a prominent aspect of this engagement as well as a central element of the creation of a Persianised version of Ayurvedic treatment more likely to be circulated among Indian Muslim physicians. The Persian treatises apply new linguistic and cognitive categories to the analysis of the translated material; the interpretation based on the criteria of the receiving culture is added to, and sometimes replaces, the criteria of the source culture.
New Amphicocconeis (Bacillariophyta) from Raivavae and Tahiti Islands (South Pacific) and Porto Belo (Brazil), with re-examination of Psammococconeis
Authors: RIAUX-GOBIN CATHERINE , GARCIA MARINÊS , WITKOWSKI ANDRZEJ , SAENZ-AGUDELO5 PABLO , COSTE MICHEL , DANISZEWSKA-KOWALCZYK GENOWEFA
Published: August 2021

Psammococconeis and Amphicocconeis are recently created diatom genera showing a high morphological plasticity-variability, making particularly difficult identification only based on morphology. The sternum valve (SV) of Amphicocconeis is very similar to that of Cocconeis, whereas its raphe valve (RV) is highly dissimilar between the two genera. The RV in Amphicocconeis has curved terminal raphe fissures and striae composed of macroareolae with more or less complex arrangement, unique to each taxon. The Amphicocconeis valvocopulae are most of the time extended, with pores arranged along rows, or clusters of pores, and are an important taxonomic criterion. Several Amphicocconeis were originally described as Cocconeis and thereafter renamed after accurate examination with scanning electron microscopy (SEM). The number of described Amphicocconeis is low, while numerous species probably remain to be described, named or renamed. Several tropical Amphicocconeis from two Polynesian archipelagos are here investigated, from which three are described as new. Psammococconeis is a genus established prior to Amphicocconeis, originally described with simple terminal raphe endings, while their SV has characteristics close to Amphicocconeis. Psammococconeis is here re-defined as an invalid genus, after re-examination of the Brazilian type material of P. brasiliensis M.Garcia (renamed as Amphicocconeis brasilensis comb. nov.), and a new Amphicocconeis is described from this Brazilian material.
Thottea aroangensis, a new species of Aristolochiaceae from central Vietnam
Authors: LE TUAN ANH , DINH DIEN , DOAN QUOC TUAN , NGUYEN QUANG HOA ANH , TAGANE SHUICHIRO
Published: August 2021

Thottea aroangensis T.A. Le, D. Dien & Tagane (Aristolochiaceae) is described based on the specimen collected from the A Roang commune, A Luoi district, Thua Thien Hue province, central Vietnam. This species is characterized by subshrub habit 70–90 cm tall, inflorescence at base of stem close to ground level, campanulate and obscurely lobed perianth ca. 2.6 cm long, inside of perianth tube with creamy white patches, and 20 stamens in 2 whorls, by which combination it is clearly distinguished from the other species of Thottea in Vietnam and its surrounding countries. Morphological descriptions, photographs, a distribution map, vernacular name, and preliminary conservation status are provided for T. aroangensis.
Mehregan, I., Younesi, S. & Liden, M. (2021). Donysia avia (Primulaceae), a new species from Zagros Mountains (Iran). Phytotaxa 511 (3): 296–300.
Authors: MEHREGAN IRAJ , YOUNESI SIMIN , LIDÉN MAGNUS
Published: August 2021

Erratum
Book review: Matthew C. Klein and Michael Pettis, Trade Wars Are Class Wars: How Rising Inequality Distorts the Global Economy and Threatens International Peace
Authors: Braunschweig Oliver
Published: August 2021

Matthew C. Klein and Michael Pettis, Trade Wars Are Class Wars: How Rising Inequality Distorts the Global Economy and Threatens International Peace. Yale University Press, 2020, US$28, 269 pp., ISBN 978-0-300-24417-5.
How Starting Strategy and Network Structure Shape Problemistic Search: An Examination of Venture Capital Firms
Authors: Duke Jake , Havakhor Taha , Mui Rachel , Parker Owen
Published: August 2021

Building on the behavioral theory of the firm, we empirically examine how starting strategies and syndication networks can influence venture capital (VC) firms’ problemistic search. We propose that: (a) depending on a VC’s strategic starting point, that is, the VC’s extent of specialization, the directionality of problemistic search may change to either expanding or contracting search activities; and (b) depending on search direction, structural holes in syndication networks can either impede or facilitate the problemistic search process. In a sample of U.S. VC firms, we find results consistent with our predictions, which have important implications for entrepreneurship and organizational strategy research.
Steady-state and start-up transient responses of a belt-driven starter generator system for micro-hybrid electric vehicles
Authors: Li Deyu , Zhu Hao , Zhu Weidong , He Zao , Zhou Biwen , Fan Wei
Published: August 2021

For micro-hybrid electric vehicles, the belt-driven starter generator system is a typical idle stop–start system that is used to substitute the traditional engine front-end accessory drive system. The aim of this work is to present a method to investigate steady-state and start-up transient responses of a typical belt-driven starter generator system with twin tensioner arms for micro-hybrid electric vehicles. A dynamic model of the belt-driven starter generator system is established for this scheme, where a smoothing dynamic friction model considering the velocity-weakening effect is presented to model the tensioner dry friction. Unlike some traditional dynamic models of the belt-driven starter generator system that the engine dynamics and dynamics of the belt-driven starter generator system are decoupled, an engine dynamic model, which is embedded in the dynamic model of the belt-driven starter generator system, is also established to calculate engine resistance torques at the engine starting process stage. Influences of the tensioner dry friction and stiffness on steady-state responses of the belt-driven starter generator system especially the stick–slip oscillations of the twin tensioner arms are examined. Angular oscillations and rotation speed variations of the belt-driven starter generator pulley and C/S pulley as well as the belt tension variations during the engine starting process are calculated. Influences of the tensioner dry friction and stiffness on transient dynamic performances of the belt-driven starter generator system during the engine starting process and its starting efficiency are investigated.
Cerebral venous sinus thrombosis associated with vaccine-induced thrombotic thrombocytopenia
Authors: Yahyavi-Firouz-Abadi Noushin , Naik Rakhi P
Published: August 2021

Thrombosis-thrombocytopenia syndrome and cerebral venous sinus thrombosis have been rarely reported in patients who have received severe acute respiratory syndrome coronavirus 2 adenoviral vector vaccines. Awareness of this potential adverse effect, recognizing early clinical symptoms and subtle signs of cerebral venous sinus thrombosis on head computed tomography and brain magnetic resonance imaging, appropriate vascular imaging, and unique treatment for this condition is critical. This is a report of a case of vaccine-induced thrombotic thrombocytopenia and associated cerebral venous sinus thrombosis with emphasis on imaging and clinical course.
The Impact of Climate Change on the Resistance of Rice Near-Isogenic Lines with Resistance Genes Against Brown Planthopper
Authors: Kuang Yun-Hung , Fang Yu-Fu , Lin Shau-Ching , Tsai Shin-Fu , Yang Zhi-Wei , Li Charng-Pei , Huang Shou-Horng , Hechanova Sherry Lou , Jena Kshirod K. , Chuang Wen-Po
Published: August 2021

Background

The impact of climate change on insect resistance genes is elusive. Hence, we investigated the responses of rice near-isogenic lines (NILs) that carry resistance genes against brown planthopper (BPH) under different environmental conditions.

Results

We tested these NILs under three environmental settings (the atmospheric temperature with corresponding carbon dioxide at the ambient, year 2050 and year 2100) based on the Intergovernmental Panel on Climate Change prediction. Comparing between different environments, two of nine NILs that carried a single BPH-resistant gene maintained their resistance under the environmental changes, whereas two of three NILs showed gene pyramiding with two maintained BPH resistance genes despite the environmental changes. In addition, two NILs (NIL-BPH17 and NIL-BPH20) were examined in their antibiosis and antixenosis effects under these environmental changes. BPH showed different responses to these two NILs, where the inhibitory effect of NIL-BPH17 on the BPH growth and development was unaffected, while NIL-BPH20 may have lost its resistance during the environmental changes.

Conclusion

Our results indicate that BPH resistance genes could be affected by climate change. NIL-BPH17 has a strong inhibitory effect on BPH feeding on phloem and would be unaffected by environmental changes, while NIL-BPH20 would lose its ability during the environmental changes.
Effects of a pharmaceutical care intervention on clinical outcomes and patient adherence in coronary heart disease: the MIMeRiC randomized controlled trial
Authors: Östbring Malin Johansson , Eriksson Tommy , Petersson Göran , Hellström Lina
Published: August 2021

Background

In the treatment of coronary heart disease, secondary prevention goals are still often unmet and poor adherence to prescribed drugs has been suggested as one of the reasons. We aimed to investigate whether pharmaceutical care by a pharmacist at the cardiology clinic trained in motivational interviewing improves clinical outcomes and patient adherence.

Methods

This was a prospective, randomized, controlled, outcomes-blinded trial designed to compare pharmaceutical care follow-up with standard care. After standard follow-up at the cardiology clinic, patients in the intervention group were seen by a clinical pharmacist two to five times as required over seven months. Pharmacists were trained to use motivational interviewing in the consultations and they tailored their support to each patient’s clinical needs and beliefs about medicines. The primary study end-point was the proportion of patients who reached the treatment goal for low-density lipoprotein cholesterol by 12 months after discharge. The key secondary outcome was patient adherence to lipid-lowering therapy at 15 months after discharge, and other secondary outcomes were the effects on patient adherence to other preventive drugs, systolic blood pressure, disease-specific quality of life, and healthcare use.

Results

316 patients were included. The proportion of patients who reached the target for low-density lipoprotein cholesterol were 37.0% in the intervention group and 44.2% in the control group (P = .263). More intervention than control patients were adherent to cholesterol-lowering drugs (88 vs 77%; P = .033) and aspirin (97 vs 91%; P = .036) but not to beta-blocking agents or renin–angiotensin–aldosterone system inhibitors.

Conclusions

Our intervention had no positive effects on risk factors for CHD, but it increased patient adherence. Further investigation of the intervention process is needed to explore the difference in results between patient adherence and medication effects. Longer follow-up of healthcare use and mortality will determine if the increased adherence per se eventually will have a meaningful effect on patient health.

Trial registration: ClinicalTrials.gov NCT02102503, 03/04/2014 retrospectively registered.
A phenomics approach for antiviral drug discovery
Authors: Rietdijk Jonne , Tampere Marianna , Pettke Aleksandra , Georgiev Polina , Lapins Maris , Warpman-Berglund Ulrika , Spjuth Ola , Puumalainen Marjo-Riitta , Carreras-Puigvert Jordi
Published: August 2021

Background

The emergence and continued global spread of the current COVID-19 pandemic has highlighted the need for methods to identify novel or repurposed therapeutic drugs in a fast and effective way. Despite the availability of methods for the discovery of antiviral drugs, the majority tend to focus on the effects of such drugs on a given virus, its constituent proteins, or enzymatic activity, often neglecting the consequences on host cells. This may lead to partial assessment of the efficacy of the tested anti-viral compounds, as potential toxicity impacting the overall physiology of host cells may mask the effects of both viral infection and drug candidates. Here we present a method able to assess the general health of host cells based on morphological profiling, for untargeted phenotypic drug screening against viral infections.

Results

We combine Cell Painting with antibody-based detection of viral infection in a single assay. We designed an image analysis pipeline for segmentation and classification of virus-infected and non-infected cells, followed by extraction of morphological properties. We show that this methodology can successfully capture virus-induced phenotypic signatures of MRC-5 human lung fibroblasts infected with human coronavirus 229E (CoV-229E). Moreover, we demonstrate that our method can be used in phenotypic drug screening using a panel of nine host- and virus-targeting antivirals. Treatment with effective antiviral compounds reversed the morphological profile of the host cells towards a non-infected state.

Conclusions

The phenomics approach presented here, which makes use of a modified Cell Painting protocol by incorporating an anti-virus antibody stain, can be used for the unbiased morphological profiling of virus infection on host cells. The method can identify antiviral reference compounds, as well as novel antivirals, demonstrating its suitability to be implemented as a strategy for antiviral drug repurposing and drug discovery.
Visceral adiposity index and atherogenic index of plasma as useful predictors of risk of cardiovascular diseases: evidence from a cohort study in Iran
Authors: Hamzeh Behrooz , Pasdar Yahya , Mirzaei Narmin , Faramani Roya Safari , Najafi Farid , Shakiba Ebrahim , Darbandi Mitra
Published: August 2021

Background

Visceral adiposity index (VAI) and atherogenic index of plasma (AIP) are relatively new indicators for predicting non-communicable diseases (NCDs). Therefore, the present study was done to assess the association of AIP and VAI with risk of cardiovascular diseases (CVDs).

Methods

This cross-sectional study was conducted on 7,362 individuals aged between 35 and 65 years old participated in Ravansar non-communicable diseases (RaNCD) cohort study. AIP was calculated based on levels of triglyceride and high -density lipoprotein cholesterol (HDL-C). VAI was calculated using values of body mass index (BMI), waist circumference (WC), triglyceride, and HDL-C. Logistic regression models were used to assess the association of AIP and VAI with risk of CVDs.

Results

Mean values of anthropometric indices, lipid profile, AIP, and VAI were significantly higher in patients with CVDs than individuals without CVDs (P < 0.001). Mean values of anthropometric indices, lipid profile, and NCDs including hypertension, dyslipidemia, diabetes, metabolic syndrome (MetS), and CVDs in the third tertile of AIP and VAI were significantly increased compared to the first tertile (P < 0.001). After adjusting confounding factors, risk of CVDs in the third tertile of AIP was (OR = 1.32, 95 % CI: 1.03, 1.69) significantly increased compared to the first tertile. Risk of CVDs in the third tertile of VAI was (OR = 1.48, 95 % CI: 1.12, 1.97) significantly increased compared to the first tertile.

Conclusions

According to the findings, AIP and VAI were positively associated with risk of CVDs. Therefore, AIP and VAI can be useful in identifying high-risk subgroups of CVDs in general population.
Molecular biochemical aspects of salt (sodium chloride) in inflammation and immune response with reference to hypertension and type 2 diabetes mellitus
Authors: Das Undurti N.
Published: August 2021

Obesity, insulin resistance, type 2 diabetes mellitus (T2DM) and hypertension (HTN) are common that are associated with low-grade systemic inflammation. Diet, genetic factors, inflammation, and immunocytes and their cytokines play a role in their pathobiology. But the exact role of sodium, potassium, magnesium and other minerals, trace elements and vitamins in the pathogenesis of HTN and T2DM is not known. Recent studies showed that sodium and potassium can modulate oxidative stress, inflammation, alter the autonomic nervous system and induce dysfunction of the innate and adaptive immune responses in addition to their action on renin-angiotensin-aldosterone system. These actions of sodium, potassium and magnesium and other minerals, trace elements and vitamins are likely to be secondary to their action on pro-inflammatory cytokines IL-6, TNF-α and IL-17 and metabolism of essential fatty acids that may account for their involvement in the pathobiology of insulin resistance, T2DM, HTN and autoimmune diseases.
Blood lipid profile changes in type 2 diabetic rats after tail suspension and reloading
Authors: Tanaka Shoji , Madokoro Sachiko , Inaoka Pleiades Tiharu , Yamazaki Toshiaki
Published: August 2021

Purpose

The effects of the tail suspension and reloading on the protein and lipid metabolism in muscle and blood in type 2 diabetes mellitus (T2DM) are unclear. This study evaluated the hypothesis that skeletal muscle catabolism is greater in T2DM than in non-diabetes mellitus (non-DM) rats and that the activity-dependent changes in the intramuscular lipid accumulation and blood lipid profile are poorer in T2DM than in non-DM rats.

Methods

T2DM and non-DM rats were suspended for two weeks followed by reloading for two weeks. The muscle and blood were then examined.

Results

In contrast to our hypothesis, there was no marked difference between the T2DM and non-DM groups in terms of the skeletal muscle catabolism and activity-dependent changes in intramuscular lipid accumulation. However, the blood lipid profile increased in the T2DM group compared to the non-DM group. One interesting finding in this study was the decrease in non-high-density lipoprotein (non-HDL) cholesterol levels after one week of reloading followed by a significant increase in the non-HDL cholesterol levels after two weeks of reloading in the T2DM group.

Conclusion

These results suggest that a dramatic increase in activity after a period of inactivity may rapidly improve the blood lipid profile in T2DM rats.