bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and research status of intelligent ophthalmology in China
Authors:   Shenzhen Eye Hospital, Shenzhen Eye Institute, Shenzhen 518040, Guangdong Province, China; Department of Ophthalmology, the First Affiliated Hospital of Jinan University, Guangzhou 510632, Guangdong Province, China, Gong Di , Li Xiao-Meng ,   Department of Computer Science and Engineering, Hong Kong University of Science and Technology, Hong Kong 999077, China, Wan Cheng ,   College of Artificial Intelligence, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, Jiangsu Province, China, Zhou Yong-Jin ,   Shenzhen University Health Science Center School of Biomedical Engineering, Shenzhen 518061, Guangdong Province, China, Wang Shu-Jun ,   Department of Biomedical Engineering, Hong Kong Polytechnical University, Hong Kong 999077, China, Wang Jian-Tao ,   Shenzhen Eye Hospital, Shenzhen Eye Institute, Shenzhen 518040, Guangdong Province, China, Xu Yan-Wu ,   School of Future Technology, South China University of Technology, Guangzhou 510641, Guangdong Province, China; Pazhou Lab, Guangzhou 510320, Guangdong Province, China, Zhang Shao-Chong ,   Shenzhen Eye Hospital, Shenzhen Eye Institute, Shenzhen 518040, Guangdong Province, China, Yang Wei-Hua ,   Shenzhen Eye Hospital, Shenzhen Eye Institute, Shenzhen 518040, Guangdong Province, China
Published: November 2024

This paper analyzes the current status, technological developments, academic exchange platforms, and future challenges and solutions in the field of intelligent ophthalmology (IO) in China. In terms of technology, significant progress has been made in various areas, including diabetic retinopathy, fundus image analysis, quality assessment of medical artificial intelligence products, clinical research methods, technical evaluation, and industry standards. Researchers continually enhance the safety and standardization of IO technology by formulating a series of clinical application guidelines and standards. The establishment of domestic and international academic exchange platforms provides extensive collaboration opportunities for professionals in various fields, and various academic journals serve as publication platforms for IO research. However, challenges such as technological innovation, data privacy and security, lagging regulations, and talent shortages still pose obstacles to future development. To address these issues, future efforts should focus on strengthening technological research and development, regulatory framework construction, talent cultivation, and increasing patient awareness and acceptance of new technologies. By comprehensively addressing these challenges, IO in China is poised to further lead the industry's development on a global scale, bringing more innovation and convenience to the field of ophthalmic healthcare.
Characteristics of corneal aberration in patients with bilateral keratoconus and unilateral corneal Vogt’s striae
Authors:   Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an 710004, Shaanxi Province, China, Wei Sheng-Sheng , Wu Zhi-Qing ,   Department of Ophthalmology, Hospital of Shaanxi Normal University, Xi'an 710004, Shaanxi Province, China, Liu Jian-Guo ,   Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an 710004, Shaanxi Province, China, Du Jing ,   Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an 710004, Shaanxi Province, China, Li Jing ,   Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an 710004, Shaanxi Province, China, Zhang Yao-Hua ,   Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, Xi'an 710004, Shaanxi Province, China
Published: November 2024

AIM: To assess the corneal high-order aberration (HOA) and its correlation with corneal morphological parameters in patients with bilateral keratoconus (KCN) and unilateral Vogt's striae.
METHODS: A total of 168 eyes of 84 patients with KCN, whose corneas had definite signs of unilateral Vogt's striae, were enrolled. Corneal HOA and morphological parameters were measured using Pentacam HR.
RESULTS: The corneal morphological parameters between KCN eyes with and without Vogt's striae were evidently different (P<0.001). The 3rd coma 90°, 4th spherical aberration, 5th coma 90°, root-mean-square (RMS) (total), and RMS (HOA) in the front, back surfaces and total cornea in KCN eyes with Vogt's striae were significantly higher than those in KCN eyes without Vogt's striae (P<0.001). In KCN eyes with Vogt's striae, the 3rd coma 90° and 4th spherical aberration in the front surface and total cornea were negatively correlated with flat keratometry value (K1), steep keratometry value (K2), mean keratometry value (Km), maximum keratometry value (Kmax), anterior corneal elevation (ACE), and posterior corneal elevation (PCE; P<0.05). The 3rd coma 90°, 4th spherical aberration in back surface and RMS (total), RMS (HOA) in the front, back surfaces, total cornea were positively correlated with K1, K2, Km, Kmax, ACE, and PCE (P<0.05).
CONCLUSION: Corneal HOA especially vertical coma and spherical aberration may increase when Vogt's striae appeared in KCN eyes. The scale of increase is significantly related with changes in corneal shapes.
Transcapsular scleral fixation of the standard capsular tension ring and in-the-bag intraocular lens implantation for severely subluxated lenses
Authors:   School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, Li Hong-Zhe , Zhu Ze-Hui ,   School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, Zhao Yin-Ying ,   School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, Chang Ping-Jun ,   School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, Zhao Yun-E ,   School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China
Published: November 2024

AIM: To present a technique of transcapsular scleral fixation of the standard capsular tension ring (CTR) through equatorial capsulotomy and in-the-bag intraocular lens (IOL) implantation in subluxated lenses.
METHODS: This retrospective consecutive case series included patients with subluxated lenses by more than 180 degrees who underwent lens extraction, transcapsular scleral fixation of the standard CTR through equatorial capsulotomy, in-the-bag IOL implantation and with at least 6mo follow-up. Preoperative and postoperative best corrected visual acuity (BCVA), intraocular pressure (IOP), complications, and postoperative IOL tilt and decentration were recorded.
RESULTS: Nine eyes of 7 patients with a mean follow-up of 11.0±3.7mo were included in this study. The BCVA was significantly improved from 0.64±0.22 logMAR preoperatively to 0.21±0.19 logMAR postoperatively (P<0.001). The IOP was within the normal range postoperatively. The mean tilt of the IOL was 4.30°±2.31° (range, 1.0° to 8.9°) and the mean decentration of the IOL was 0.37±0.12 mm (range, 0.14 to 0.50 mm). No visually threatened intraoperative and postoperative complications were detected during the follow-up period.
CONCLUSION: This is a safe and effective surgical technique for managing patients with severely subluxated lenses. It has achieved favorable outcomes with fewer surgical manipulations and less need for advanced capsular support devices.
Factors Influencing Discontinuation of Long-Acting Reversible Contraceptive Methods Among Women
in Bahir Dar City, Northwest Ethiopia: A Cross-Sectional Study
Authors: Melesse Yilkal Dagnaw , Lake Fenta Selamawit , Hiyaru Wassie Toyiba , Getu Alemwork Abie , Liben Seid Wodajo , Wudu Zelalem Feleke , Zegeye Ambaye Minayehu , Mulu Mastewal Yechale , Kebede Getahun Deguale , Bogale Tewodros Worku
Published: November 2024

Introduction

Long-acting reversible contraceptive discontinuation is the removal before completion of the intended
lifespan of the method. Despite the improvement in utilization, discontinuation is becoming high. There is no study conducted
on discontinuation and associated factors of long-acting reversible contraceptives in Bahir Dar City. The aim of this study
was to assess the proportion and associated factors of discontinuation of Long-Acting Reversible Contraceptives among
women in health facilities of Bahir Dar city, Northwest Ethiopia.

Methods

A health facility-based cross-sectional design was conducted on 415 respondents from April 1 to May 30,
2021. A total of 11 health facilities were included and all reproductive age women who were using Long-acting reversible
contraceptives came to the selected health facilities for any issue concerning the method before completion of life span of
the method were included in this study. Data were collected through face-to-face interview questionnaires using a systematic
random sampling method. Epi Data version 3.1 and Statistical Package for Social Sciences were used for data entry and
analysis, respectively. Logistic regression analyses were used, and a P value less than 0.05 was considered a statistically
significant factor for discontinuation.

Results

The overall proportion of discontinuation of long-acting reversible contraceptives was 66.3% (95% CI: 61.42-
69.13). No formal education (AOR=0.49; 95% CI: 0.30-0.82,P: 0.021), primary education (AOR=0.39; 95% CI: 0.18-0.81,
P:0.012), wish to pregnancy (AOR=2.57; 95% CI: 1.64 to 4.02,P: <0.001), no history of contraceptive use (AOR=2.01; 95%
CI: 1.19 to 3.38, P: 0.009), no counselling (AOR=1.68; 95% CI: 1.08-2.62,P: 0.021), and side effects (AOR=1.95; 95% CI:
1.21-3.16,P:0.006) were the factors associated with discontinuation.

Conclusions

The overall discontinuation of long-acting reversible contraceptives among women was low compared
to Ethiopian Demographic Health Survey 2016. Practice pre-insertion counselling, early side effect management, create
community awareness about the methods to decrease discontinuation, healthcare providers should perform their duties in
line with the standards and quality of Long-acting reversible contraceptive service provision through qualitative research are
recommended.
Enhancing Student Engagement in Electronic Platforms: E-Gallery Walk
Authors: Alkhateeb Nazdar Ezzaddin , Bigdeli Shoaleh , Mirhosseini Fakhrosadat
Published: November 2024

The COVID-19 pandemic was one of the most challenging situations that affected all aspects of humans’ life including education and active face to face teaching and learning methods. Engaging learners in the teaching and learning process, teaching faculty members, and employing technologies to enhance teaching and learning requires adapting instructional methods based on diverse situations, especially in crises and force majeure. This study was an attempt to design and implement an electronic gallery-walk (e-gallery-walk) based on Gagne’s Nine Events of Instruction. A teacher training e-course was designed, developed, and implemented during COVID-19 era at the Center of Pedagogical Training and Academic Development at Hawler Medical University, Iraq. Moreover, for the purposes of this study different formative assessment tools were designed and implemented. Thirty-eight MSc and PhD graduates from different medical specialties who were university instructors participated in this study and their learning was assessed via the designed assessment tools. This hands-on-experience indicates that a carefully designed and implemented e-gallery walk enhances student-centered activity in an online faculty development program. This approach by improving student engagement results in more meaningful discussion and peer instruction. The e-gallery walk gives teachers and students a valuable experience of using technological advances and digital tools to modify face-to-face activities. These tools ensure successful teaching and learning practice in critical conditions when remote activities are deemed necessary. The study findings indicate that peer and teacher immediate feedback is highly influential on the quality of teaching and learning and a modified e-gallery walk could be a suitable choice to improve the process in virtual settings.
Development, Implementation and Evaluation of the Fellowship Course Regenerative Medicine in Dentistry
Authors: Bahrami Naghmeh , Bayat Mohammad , Ai Jafar , Shirazian Shiva , Mohammadi Farnoosh , Tehrani Mona Mohajeri , Mafinejad Mahboobeh Khabaz
Published: November 2024

Introduction: Scientists have developed solutions, for oral health by leveraging advancements in medicine. These solutions, known as “ reconstructive dentistry “ aim to address the limitations and short lifespan of restorative methods. Unlike restorative treatments, reconstructive dentistry focuses on not only restoring the structure of tissues but also their physiological functions. To achieve this, it requires an effort among dentists, biologists, stem cell researchers, material scientists, tissue engineers and other experts. Consequently, this study was carried out to create and evaluate a fellowship program called “Reconstructive Medicine in Dentistry.” The program aims to foster an approach towards reconstruction, in dentistry.
Materials and Methods: This research involved three stages. Utilized a mixed method approach. In the first stage, we developed a design based on the Kern model, which involved conducting a review of relevant studies to extract and determine the goals and topics related to medical reconstruction, in dentistry. Expert panel meetings were held to finalize these goals and topics. For each target group, we identified the learners, learning environment and educational strategies. We also made arrangements for implementing the program. Established evaluation methods for both students and the program itself. Subsequently, we implemented the designed curriculum for two groups of students. Finally, we evaluated the program’s effectiveness through questionnaires and semi structured interviews, with students, professors and organizers. The collected data was analyzed using statistics.
Results: In 2020 and 2021, two groups of students were meticulously selected from disciplines such as maxillofacial surgeons, oral medicine specialists, periodontists, endodontists, and more, after passing the entrance exam. The primary objective of this program is to educate graduates with the skills to restore missing tissues in the mouth, jaw and facial regions using cutting edge regenerative medicine techniques. The curriculum was developed in collaboration with experts from areas like tissue engineering, dental specialization (including maxillofacial surgeons) biomaterials and developmental biology. Both students and professors expressed satisfaction, with the program.
Conclusion: A group of professors, from specialties came together to implement a fellowship program in reconstructive dentistry. The main goal of this program was to train specialists in tissue reconstruction for patients who have suffered jaw and facial injuries; by using advanced methods in medicine. Additionally, this initiative can also be a step towards strengthening the university’s movement towards third and fourth-generation universities. The findings from this study can provide insights, for those involved in planning and implementing interdisciplinary fellowship programs.
Invasive Mucormycosis and the Importance of Molecular Diagnostics
Authors: Mohamadnia Abdolreza , Abbasi Amir Jalal , Mohammadi Farnoush , Fotook Kiae Seyedeh Zahra , Mohajeri Tehrani Mona , Lookzadeh Somaieh , Yassari Fatemeh , Shafaghi Shadi , Ahmadi Farnaz , Bahrami Naghmeh
Published: November 2024

introduction: Mucormycosis, an infection, with a high death rate, requires understanding its symptoms, diagnosis methods and treatment options due, to its growing occurrence. The research employs a molecular method to evaluate the diagnosis of the mucormycosis.
Methods and material: In this study, we obtained 30 samples from patients undergoing diagnosis and conducted DNA extraction. Additionally, DNA extraction was carried out on 30 tissue samples suspected of infection in paraffin blocks. Subsequently, PCR and Real-time PCR were performed using targeted primers, for mucormycosis followed by analysis of the results.
Results: In the research findings among 30 liquid samples 8 tested positive, for mucor using the PCR method. 10 using the Real-time PCR method. Similarly, out of 30 tissue samples, 9 cases showed mucor presence with the PCR method and 11 cases, with the Realtime PCR method.
Conclusion: In this study, real-time PCR and PCR techniques showed promising and faster results in detecting Mucor than the culture approach. The molecular methods provided results that could be of great use for scenarios.
The Relationship between Wellbeing and Academic Achievement: A Comprehensive Cross-Sectional Analysis of System Wide Data From 2016-2019
Authors: Marrone Rebecca , Lam Benjamin , Barthakur Abhinava , Brinkman Sally , Dawson Shane , Gabriel Florence
Published: November 2024

Learning analytics research has long flagged the importance of social and emotional well-being on student academic progress and outcomes. However, few studies have examined the interplay between well-being measures and academic outcomes at scale. This research examined the relationship between the Well-being Engagement Collection (WEC) index and student academic outcomes, using cross-sectional panel data from 215,635 students in Years 4–10 in South Australia, spanning 2016 to 2019. Using linear hierarchical mixed models, results indicate a modest impact of the WEC index on these outcomes, with learning readiness emerging as the most influential component. The effects of the WEC index remained stable across various student year levels and census periods. A notable finding was the more pronounced influence of the WEC index on male students, particularly in literacy, suggesting gender-specific variations in the role of emotional well-being on academic achievement. The study underscores the potential of learning analytics in future investigations to deepen our understanding of the nexus between socio-emotional factors and academic outcomes.
“Nerdesin Eski Türkiyemmm”: Bir Karşı-Mağduriyet Söylemi Olarak Yitirilmiş Rejim Nostaljisi
Authors: Başaran İnce Gökçen
Published: November 2024

Nostalji literatürü yaygın olarak, radikal değişim dönemlerinde, daha sabit, sakin ve mutlu algılanan bir geçmiş imgesine yönelik özlemin, yani kolektif nostaljinin arttığını varsayar. Türkiye’nin özellikle son on yılda bu tarz bir kökten dönüşüm geçirdiği ileri sürülebilir. Bu süreç, “Eski-Yeni Türkiye” karşıtlığında vücut bulan, kutuplaşmayı artırıcı, politik bir söyleme de dönüşmüştür. Eski Türkiye’yi “altın çağ” olarak görenler için bu dönemin popüler kültürü, iyileştirici, bugünden kaçışı sağlayan bir işlev edinmektedir. Şüphesiz bu durum, nostaljinin bir “duygu” olarak sadece olumlu olana yönelmesiyle ilgilidir. Bu çalışma, “Eski-Yeni Türkiye” gerilimini, “yitirilmiş rejim nostaljisi” kavramı bağlamında, Old Laik Days (@oldlaikdayss) adlı Instagram hesabı üzerinden okumayı hedeflemektedir. Paylaşımlar incelendiğinde, yitirilmiş rejim nostaljisi (geçmişi yüceltme), geçmiş ile bugünü kıyaslama, iç-şarkiyatçılık ve bastırılmış hıncı dolayımlama temalarının baskın olduğu görülmektedir.
Clinical, statistical and diagnostic features of relapse and continued growth of intracranial meningiomas
Authors: Kukanov K. K. , Kukanova O. M. , Kiyashko S. S. , Maslova L. N. , Ivanova N. E. , Sukhoparov P. D. , Olyushin V. E. , Samochernych K. A.
Published: November 2024

Introduction. Meningiomas account for 18–34 % of all intracranial tumors in adults and are the second most common among all intracranial neoplasms. Recurrence and progression account for 25 %, on average, even after radical tumor resection and radiotherapy., that worsens the prognosis and functional outcome of the disease significantly. Clinical manifestations often occur with large tumor sizes, initial symptoms are not taken into account by patients and by doctors during follow-up after surgery.

Purpose. To assess the clinical features in patients with recurrence and progression of intracranial meningiomas and to identify the features of clinical manifestations in the progression of meningiomas.

Materials and methods. The study was based on patients (132 cases) with recurrence and progression of intracranial meningiomas with Grade I–III according to histology, who were treated in the Department of Neurosurgery No. 4 of the Polenov Neurosurgical Institute in the period of time from 2014 to 2024. Assessment of clinical neurological symptoms was performed according to standard methods in clinical practice. The results were evaluated using the software system STATISTICA 10.0.

Results. The multifactorial analysis of the clinical manifestations of the disease in recurrent intracranial meningiomas was performed, the main trends in oncogenesis were identified, and the most common clinical symptoms of tumor progression were identified, which must be taken into account by doctors during follow-up after surgery.
Adult-onset familial mediterranean fever: case reports with literature review
Authors: Myachikova V. Yu. , Aksenova K. A. , Khodot A. A. , Maslyanskiy A. L.
Published: November 2024

Familial Mediterranean Fever (FMF) is a rare monogenic autoinflammatory disease that typically manifests in early childhood. The disease is characterized by its prevalence within a specific ethnic group. Nevertheless, FMF can also manifest in later stages of life among individuals with or without an ethnic background. We present two case reports of FMF patients, where the onset of the disease occurred in the third decade of life. These cases emphasize the importance of including monogenic autoinflammatory diseases in the differential diagnosis of adults presenting with fever of unknown origin and exhibiting typical FMF symptoms regardless of ethnicity.
Cesarstwo rzymskie
Authors: Kelly Christopher , Kompa Andrzej
Published: November 2024

Autor zaprasza czytelnika w podróż po historii – od Augusta do Kommodusa – i spuściźnie cesarstwa rzymskiego. Ukazuje je przede wszystkim jako imperium siły stosujące mieszankę przemocy, ucisku, porządku i taktycznego użycia władzy, by zapewnić trwanie jednolitej kultury. Czytelnik dowie się nie tylko, jak powstało imperium, jak nim zarządzano, jaka była religia i struktura społeczna, lecz także w jaki sposób lokalne kultury uległy romanizacji i jak ludzie w odległych krainach zaczęli wierzyć w cesarza jako boga. Znajdzie tu również szkic o tym, jak przedstawiano cesarstwo w czasach współczesnych, począwszy od oświecenia przez imperium brytyjskie czasów wiktoriańskich po najnowsze hollywoodzkie hity kinowe.
 
The Roman Empire: A Very Short Introduction was originally published in English in 2006. This translation is published by arrangement with Oxford University Press. Wydawnictwo Uniwersytetu Łódzkiego is responsible for this translation from the original work and Oxford University Press shall have no liability for any errors, omissions or inaccuracies or ambiguities in such translation or for any losses caused by reliance thereon.
Insolvencia y sostenibilidad
Authors: Flores Segura Marta
Published: November 2024

Este trabajo analiza el papel que juega la sostenibilidad en las operaciones de reestructuración empresarial realizadas en el marco de procedimientos de insolvencia, tanto concursales como preconcursales. A estos efectos, se revisita el debate sobre los fines de los procedimientos de insolvencia y sobre quiénes son los stakeholders en los mismos. En relación con esta cuestión, se analizan con detalle las últimas tendencias internacionales en el derecho de la insolvencia y, sobre la base de lo anterior, se ensaya una aproximación teórica en torno a la admisibilidad y la conveniencia de la consideración de intereses basados en la sostenibilidad en los procedimientos de insolvencia y al impacto que ello puede tener sobre los intereses de los acreedores.
Pautas para el reconocimiento de créditos comerciales en el procedimiento concursal peruano
Authors: Enrique Palma Navea Jose Enrique , Cervantes Villacorta Carla
Published: November 2024

El artículo analiza, desde la perspectiva del derecho concursal, los créditos generados por las relaciones de naturaleza comercial surgidas entre un deudor sometido a concurso y sus acreedores. Asimismo, desarrolla la exigencia probatoria necesaria para acreditar ante la autoridad concursal peruana el origen, existencia, legitimidad, titularidad y cuantía de este tipo de créditos, ello a efectos que el titular de tales créditos obtenga el reconocimiento de sus créditos ante la autoridad concursal y pueda ejercer los derechos económicos y políticos que emanan de tal reconocimiento en el marco del procedimiento concursal. El análisis se realiza sobre la base de diversa jurisprudencia del Indecopi.
Diversity Within Olfactory Receptor Gene Families: A Case Study of Humans, Mice, Rats, and Elephants
Authors: Crasto Chiquito J
Published: November 2024

Olfactory receptor (OR) gene families are the largest gene families for all mammals with published genomes. We performed a clustering analysis of the protein sequences of all identified functional olfactory receptor genes for Homo sapiens, Mus musculus, Rattus norvegicus, and Loxodonta africana. To accomplish this, we used the k-means clustering methodology.
IL CONTRASTO FRA CITTÀ E CAMPAGNA OSSIA FRA MATURITÀ E INFANZIA NEL ROMANZO IL DIAVOLO SULLE COLLINE DI CESARE PAVESE
Authors: Mejdanija Mirza
Published: November 2024

Il diavolo sulle colline è estremamente ricco di temi, ci si trovano riuniti quasi tutti i miti di Pavese. Il tema sostanziale è il contrasto fra città e campagna, come si può dedurre, tra l'altro, dal titolo, ma questo contrasto si arricchisce di nuovi significati. L'avventura dei tre ragazzi è mossa all'inizio del romanzo da una curiosità infantile, dalla necessità della scoperta che si identifica con il bisogno di toccare il limite, di violare la norma, che spiega il motivo dei vagabondaggi notturni. Si aggiungono poi altri miti dello scrittore torinese, come il toro, il caldo estivo come simbolo della morte, la luna, la collina. Ma il motivo fondamentale è l'iniziazione al mistero della vita, tramite il quale avviene la scoperta progressiva di una realtà affascinante e proibita. La tensione rimane nell'inconscio dei personaggi, che sono attirati e coinvolti in una vicenda che trascende le loro forze e della quale non riescono a rendersi conto, visto che i tre ragazzi sono i testimoni o gli agenti passivi di una situazione abnorme e oscura che è misteriosa e che li trascende. Inoltre, la parola 'festa' è la parola-chiave del romanzo e mostra qualcosa di perduto. La festa qui ha in sé qualcosa di grottesco e di morto. Quello che dava valore all'esperienza collettiva della notte e del sesso, dove si svelava la vera realtà dei grandi simboli della terra, della luna, del sangue, della morte, era l'antica festa. Adesso che essa è impossibile, le visioni sessuali e notturne sopravvivono sul limitare della festa degli uomini. Invadono in modo incerto la vita dell'uomo, che possiede ancora il senso di festività, ma non riesce a manifestarlo attraverso feste che siano davvero salvatrici.
Effects of autologous platelet-rich plasma in promoting endometrial thickness on patients with thin endometrium following IVF
Authors: Pratama Gita , Agustina Elizabeth , Yanfaunnas Atika Mahira , Maidarti Mila , Harzif Achmad Kemal , Muharam R. , Wiweko Budi
Published: November 2024

HIGHLIGHTS

It was observed that autologous PRP substantially increased endometrial thickness in individuals experiencing infertility linked to a thin endometrium.
The elevated clinical pregnancy rate emphasizes the favorable effectiveness of autologous PRP in addressing issues related to a thin endometrium in IVF programs.

 
ABSTRACT
Objective: The objective of this research was to investigate the impact of autologous platelet-rich plasma (PRP) in enhancing endometrial thickness among individuals experiencing infertility associated with a thin endometrium.
Materials and Methods: Nine individuals with a thin endometrium who participated in an in vitro fertilization (IVF) program were enrolled in the study. This study occurred in Yasmin Clinic, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Patients underwent a hormone replacement protocol involving the preparation of the endometrium with estradiol valerate. Treatment with PRP was initiated when the endometrial thickness was less than 7 mm. Autologous PRP was infused into the uterine cavity between the 10th and 12th days after administering estradiol valerate, and the assessment of endometrial thickness was conducted using ultrasound 48 hours later. A second administration of PRP was provided in cases where the endometrial thickness was below 7 mm. Frozen-thawed embryo transfer (FET) will be performed if the endometrium reaches adequate thickness (minimum 7 mm).
Results: Seven of nine patients had adequate endometrial thickness followed by FET. Endometrial thickness was improved in 8 from 9 patients (88.8%). Five patients were improved at the first autologous PRP infusion (62.5%) and three patients (37.5%) at the second PRP infusion. The implantation rate was 33.3-100%, clinical pregnancy was 100%, and ongoing pregnancy rate was 83.3%.
Conclusion: The use of autologous platelet-rich plasma (PRP) successfully stimulates endometrial development in individuals with a thin endometrium during frozen-thawed embryo transfer.
Evaluation of anti-Mullerian hormone as parameter of ovarian function in patients with systemic lupus erythematosus: A systematic review and meta-analysis
Authors: Nooryanto Mukhammad , Wulandari Wulandari
Published: November 2024

HIGHLIGHTS

Systemic Lupus Erythematosus (SLE) patients show a strong correlation between Anti-Mullerian Hormone (AMH) levels and ovarian function. Lower AMH levels indicate higher risk of impaired ovarian function and diminished reserve, as revealed by this meta-analysis.
The comprehensive synthesis of available data in this study has important clinical implications for the management and counseling of Systemic Lupus Erythematosus (SLE) patients.

 
ABSTRACT
Objective: The assessment of ovarian function in patients with systemic lupus erythematosus (SLE) holds paramount importance for both clinicians and patients. This systematic review and meta-analysis delves into the role of anti-Mullerian hormone (AMH) as a key marker in evaluating ovarian function among SLE patients. Our study aims to provide valuable insights for clinicians managing ovarian function assessments and to offer practical recommendations for differences in therapy for patient care.
Materials and Methods: Studies comparing serum AMH levels between patients with systemic lupus erythematosus and healthy controls, as well as serum AMH levels between SLE patients, are necessary. PRISMA guidelines were used for this systematic review. Databases like PubMed, SCOPUS, EuropePMC, ProQuest, and Cochrane Central were searched using specific terms ("Anti-Mullerian Hormone" or "Ovarian Function" and "Systemic Lupus Erythematosus") for publications between 2000 and 2023. After removing duplicates, authors screened remaining articles based on abstracts, then reviewed selected abstracts in full-text. Studies meeting criteria were included based on unanimous agreement among investigators, with any disagreements resolved through author consensus.
Results: Data There were 12 eligible studies. In this research, we identified a link between SLE and diminished levels of AMH. Furthermore, it was observed that SLE patients undergoing cyclophosphamide (CYC) treatment also exhibited lowered AMH levels
Conclusion: The systematic review underscores the heightened risk of reduced ovarian reserve in SLE patients. Importantly, CYC treatment emerged as a factor contributing to compromised ovarian reserve. For individuals with systemic lupus erythematosus, particularly women in their reproductive years, assessing serum AMH levels can serve as a pivotal tool to inform therapeutic decisions and preserve ovarian health. Our study contributes to enhanced clinical understanding and patient care within the realm of SLE and reproductive health.
MicroRNAs obtained from cervical swabs in predicting preterm birth
Authors: Purbandari Rosalia , Hariyati Suheni Ninik
Published: November 2024

HIGHLIGHTS

Increased expression of certain miRNAs in women experiencing preterm birth could be linked to various molecular pathways which contributes to preterm birth.
miRNAs obtained from cervical swabs exhibit statistically significant difference in expression between women with term births and preterm births.

 
ABSTRACT
Objective: Identifying the risk of preterm birth is crucial for early intervention. miRNAs, small noncoding RNAs that regulate gene expression, play a key role in development and tissue maintenance. Under stress conditions, their regulatory functions become significant, linking them to disease states. Using miRNAs from cervical swabs as potential biomarkers could revolutionize preterm birth risk assessment. This systematic review examines current research on the effectiveness of cervical swab miRNAs in predicting and estimating preterm birth risks, aiming to enhance early detection and management strategies for preterm births.
Materials and Methods: Using the PubMed database, 14 articles were obtained using the keywords “microRNA” and “preterm”. Reviews and unrelated studies were then excluded from both pooled articles, resulting in 4 articles included in the final review. Risk of bias were examined using the Newcastle Ottawa Scale. Sample characteristics, time of cervical swab collection, and results from each study were extracted for further analysis.
Results: A total of 4 articles were included in this review. Various miRNAs were examined in and were generally successful in predicting preterm birth. miRNA-145, miRNA-199, miRNA-30, miRNA-21, and miRNA-181 family were examined by multiple studies and produced significant results in predicting preterm birth. Based on enrichment analysis, various miRNAs were found to be involved in several biomolecular signaling pathways leading to preterm birth, such as inflammation, chemokine and cytokine signaling pathway, and toll-like receptor signaling.
Conclusion: miRNAs obtained from cervical swabs exhibit statistically significant difference in expression between women with term births and preterm births. Further studies are needed to improve the predicting power and accuracy of miRNAs in preterm births.
A Verification of the Mediating Effect of Depression on the Structural Relationship between Ego Differentiation and Interpersonal Relationships in Elementary Pre-Service Teachers
Authors:   Korean Academy Welfare Counselling, Ryu Kum Joo , Park Il Soo
Published: November 2024

The purpose of this study is to establish a research model of structural relationships to analyze the effects of self-differentiation variables on interpersonal relationship variables of elementary pre-service teachers and to verify the effect of depression as a mediator. In accordance with the purpose of this study, a preliminary survey was conducted among elementary pre-service teachers enrolled in G University of Education in Chungcheongnam-do, South Chungcheong Province, and then the main survey was conducted to obtain a total of 359 data. Among them, 355 data without missing data were analyzed using statistical techniques using SPSS 21.0 and AMOS 21.0 programs. The main findings of this study are as follows. First, the level of self-differentiation of pre-service teachers was positively related to interpersonal relationships. Second, the level of self-differentiation of pre-service teachers was negatively related to depression. Third, depression was negatively related to interpersonal relationships among pre-service teachers. Fourth, depression was partially mediated in the structural relationship of the effect of ego differentiation on interpersonal relationships. These findings have theoretical implications that can be used as a basis for psychological counseling to solve interpersonal problems for citizens in early adulthood, including pre-service elementary school teachers, who are in the early stages of the life cycle, and practical implications for providing counseling education programs that can maintain smooth interpersonal relationships by increasing their levels of self-differentiation or decreasing their levels of depression.
The Effect of Maternal Self-differentiation on Perceived Adolescent Children’s Psychological Health: Sequential Mediating Effect of Mentalization and Parenting Behavior
Authors:   Korean Academy Welfare Counselling, Cho Ja Young , Yang Hae Chung
Published: November 2024

The purpose of this study was to verify the sequential mediating effect of mentalization and parenting behavior in the effect of maternal self-differentiation on perceived adolescent children's psychological health. The data were collected from 200 mothers with a middle schooler nationwide. The research model was verified with Process Macro model 6 and the significance of the mediating effect was confirmed through bootstrapping. The results was found that maternal self-differentiation directly affects on perceived adolescent children's psychological health. While the mediating effect of maternal mentalization in the relationship between maternal self-differentiation and children's psychological health was not significant, the indirect effect of parenting behavior was significant, and the sequential mediating effect of mentalization and parenting behavior was significant. Additionally, there were differences in maternal factors and pathways in affecting perceived children's psychological health according to the children's gender. The results of this study suggest that interventions that promote desirable parenting behavior by reflecting their experiences in family-of-origin, raising the level of mentalization, and understanding the children's gender differences can be effective in improving adolescent children's psychological health.
The Effects of Mindfulness on Stress in University Students: The Serial Mediating Effects of Acceptance and Happiness
Authors:   Korean Academy Welfare Counselling, Kim Eunjin
Published: November 2024

The purpose of this study is to expand understanding of the effects of mindfulness that contribute to their stress reduction by exploring the effects of mindfulness on stress in university students. To this end, based on previous studies, this study established a research model in which university students’ mindfulness affects their stress by the double mediation of acceptance and happiness, and verified the relationship between them using 263 university students data set. Descriptive statistics and Pearson’s correlation analysis were conducted to analyze the data, and the PROCESS macro (v4.2) program was used to verify the double mediation effects. The results confirmed are as follows. First, First, mindfulness, acceptance, and happiness showed significant positive correlations with each other, but they all showed significant negative correlations with stress. Second, mindfulness showed a significant direct effect on stress. Third, the significant serial mediating effects of acceptance and happiness were confirmed in the relationship between mindfulness and stress. These results are meaningful in that they broaden the understanding of the effects of effective mindfulness and its mechanisms for relieving stress in university students, and confirm the need for university student stress management programs and counseling to pay attention to positive resources such as mindfulness, acceptance, and happiness.
MENINGKATKAN KEMAMPUAN PEMAHAMAN KONSEP PECAHAN DENGAN MODEL PEMBELAJARAN KOOPERATIF TIPE STAD BERBANTUAN ALAT PERAGA PAPAN AJAIB PECAHAN
Authors: Assyifa Iqlima  , Karim  , Yuni Suryaningsih
Published: November 2024

Salah satu aspek penting dalam pembelajaran matematika adalah pemahaman konsep. Penting bagi siswa untuk memahami konsep-konsep dasar matematika dengan baik. Begitu siswa memahami suatu konsep, maka mereka dapat dengan mudah mempelajari materi yang lebih kompleks. Namun, kemampuan pemahaman konsep ini seringkali menjadi kendala bagi sebagian siswa, sehingga pendekatan pembelajaran yang inovatif diperlukan untuk membantu siswa dalam mengatasi kendala tersebut. Penelitian ini bertujuan untuk meningkatkan kemampuan pemahaman konsep siswa pada materi perkalian dan pembagian pecahan dengan model STAD berbantuan alat peraga papan ajaib pecahan. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK), dengan 2 siklus pembelajaran. Subjek dalam penelitian ini adalah siswa kelas V SDN Belitung Selatan 7 Banjarmasin tahun pelajaran 2023/2024. Hasil penelitian menunjukkan adanya peningkatan nilai rata-rata kemampuan pemahaman konsep siswa pada siklus I dan II. Jumlah siswa yang tuntas pada siklus I sebanyak 6 orang (35,29%) dan pada siklus II meningkat menjadi 15 orang (88,24%). Berdasarkan hasil analisis tersebut, dapat disimpulkan bahwa penerapan model pembelajaran STAD berbantuan alat peraga papan ajaib pecahan dapat meningkatkan kemampuan pemahaman konsep siswa kelas V SDN Belitung Selatan 7 Banjarmasin pada materi perkalian dan pembagian pecahan.
One of the essential aspects of learning mathematics is concept understanding. Students need to understand the basic concepts of mathematics well. Once students understand a concept, they can quickly learn more complex material. However, this concept of understanding ability is often an obstacle for some students, so innovative learning approaches are needed to help students overcome these obstacles. This study aims to improve students' concept understanding ability on the material of multiplication and division of fractions with the STAD model assisted by the magic fraction board props. This type of research is Classroom Action Research with 2 learning cycles. The subjects in this study were fifth-grade students of South Belitung 7 Banjarmasin Elementary School in the 2023/2024 academic year. The results showed increased students' average concept understanding ability scores in cycles I and II. The number of students who completed the first cycle was 6 people (35.29%), and in cycle II it increased to 15 people (88.24%). Based on the results of the analysis, it can be concluded that the application of the STAD learning model with the help of the magic fraction board props can improve the concept understanding ability of fifth-grade students of South Belitung 7 Banjarmasin State Elementary School on the material of multiplication and division of fractions.
PENERAPAN MODEL DISCOVERY LEARNING BERBANTUKAN LKPD UNTUK MENINGKATKAN PEMAHAMAN KONSEP PADA MATERI INTEGRAL FUNGSI ALJABAR
Authors: Huda Nuril , Amanu Betty Agustina
Published: November 2024

Penelitian ini bertujuan untuk mendeskripsikan penerapan model discovery learning berbantukan LKPD untuk meningkatkan pemahaman konsep pada materi intregal fungsi aljabar. Jenis penelitian ini merupakan Penelitian Tindakan Kelas (PTK) dengan model spiral Kemmis dan Taggart. Dilaksanakan pada bulan April-Mei 2023 selama 3 minggu dengan subjek penelitian adalah kelas XI Agama 2 MAN Kota Blitar yang berjumlah 33 peserta didik. Adapun objek penelitian adalah pemahaman konsep peserta didik pada mata pelajaran matematika khususnya materi Integral Fungsi Aljabar. Teknik pengumpulan data yang menggunakan teknik observasi, soal tes hasil belajar, dan catatan lapangan. Prosedur teknik analisis data yang digunakan adalah mengumpulan data, reduksi, mengolah data, dan menarik kesimpulan. Berdasarkan hasil penelitian menunjukkan adanya peningkatan pemahaman konsep dengan menerapakan model discovery learning berbantukan LKPD. Peningkatan yang terjadi yaitu, (1) partisipasi peserta didik selama pembelajaran menggunakan model discovery learning berbantukan LKPD pada siklus I sebesar 60,606% dan pada siklus II sebesar 84,848%, (2) pemahaman konsep dari hasil evaluasi belajar peserta didik yang memperoleh nilai lebih dari KKM pada siklus I sebesar 57,575% dan siklus II sebesar 81,818% sehingga ada meningkat sebesar 24,243%. Dapat disimpulkan bahwa RRu.
This study describes the application of discovery learning model supported by worksheet/LKPD to improve conceptual understanding on integration algebra function material. This type of research is a Classroom Action Research (CAR) with Kemmis and Taggart spiral model. It was conducted in April-May 2023 for 3 weeks with the research subject being Class XI Religion 2 MAN Kota Blitar which amounted to 33 students. The object of research is conceptual understanding of students in mathematics subjects, especially the integral material of algebraic functions. Data collection techniques used are observation techniques, learning outcomes test questions, and field notes. The data analysis technique procedure used is data collection, reduction, processing data and drawing conclusions. Based on the results of the study, it shows that there is an increase in conceptual understanding by applying the discovery learning model supported by LKPD. The increase that occurred was, (1) the participation of students during learning using the discovery learning model supported by LKPD in Cycle I amounted to 60.606% and in Cycle II amounted to 84.848%, (2) conceptual understanding from the results of student learning evaluations that obtained scores higher than KKM in Cycle I of 57.575% and Cycle II of 81.818% so that there was an increase of 24.243%. It can be concluded that the application of the discovery learning model supported by LKPD can improve concept understanding.
Yellow Fever Outbreak Temporarily Changes Dispersal Patterns in an Endangered Primate
Authors: Ponchon Aurore , Choquet Rémi , Martins Andreai , Ruiz-Miranda Carlos , Albert Cécile , Romano Valeria
Published: November 2024

Disease outbreaks can severely affect populations in the wild. However, their consequences on individual behaviours are poorly understood. We used a multi-site capture-recapture model to investigate the impacts of a yellow fever outbreak on the endangered golden lion tamarin Leontopithecus rosalia, in the highly fragmented Atlantic forest, Brazil. Annual adult survival rate severely declined in 2017-2018, coinciding with the outbreak period. Simultaneously, dispersal patterns changed temporarily, with a reduction of settlement time for individuals dispersing within the same forest fragments, and a significant increase of dispersal between forest fragments, from 0.4±0.2 to 4.3±1.5%. Those results indicate a spatial rearrangement of individuals during the outbreak potentially due to non-random mortality leading to changes in social group structure at a local and regional scale. They advocate for a better integration of host movements, host social behaviour and habitat connectivity when evaluating species response to infectious diseases.