bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from Pan-Cancer Comparative and Integrative Analyses of Driver Alterations Using Japanese and International Genomic Databases
Authors: Horie Sara , Saito Yuki , Kogure Yasunori , Mizuno Kota , Ito Yuta , Tabata Mariko , Kanai Takanori , Murakami Koichi , Koya Junji , Kataoka Keisuke
Published: May 2024

Abstract
Using 48,627 samples from the Center for Cancer Genomics and Advanced Therapeutics (C-CAT), we present a pan-cancer landscape of driver alterations and their clinical actionability in Japanese patients. Comparison with White patients in Genomics Evidence Neoplasia Information Exchange (GENIE) demonstrates high TP53 mutation frequencies in Asian patients across multiple cancer types. Integration of C-CAT, GENIE, and The Cancer Genome Atlas data reveals many cooccurring and mutually exclusive relationships between driver mutations. At pathway level, mutations in epigenetic regulators frequently cooccur with PI3K pathway molecules. Furthermore, we found significant cooccurring mutations within the epigenetic pathway. Accumulation of mutations in epigenetic regulators causes increased proliferation-related transcriptomic signatures. Loss-of-function of many epigenetic drivers inhibits cell proliferation in their wild-type cell lines, but this effect is attenuated in those harboring mutations of not only the same but also different epigenetic drivers. Our analyses dissect various genetic properties and provide valuable resources for precision medicine in cancer.
Significance:
We present a genetic landscape of 26 principal cancer types/subtypes, including Asian-prevalent ones, in Japanese patients. Multicohort data integration unveils numerous cooccurring and exclusive relationships between driver mutations, identifying cooccurrence of multiple mutations in epigenetic regulators, which coordinately cause transcriptional and phenotypic changes. These findings provide insights into epigenetic regulator–driven oncogenesis.

This article is featured in Selected Articles from This Issue, p. 695
Figure S3 from Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts
Authors: Olesinski Elyse A. , Bhatia Karanpreet Singh , Wang Chuqi , Pioso Marissa S. , Lin Xiao Xian , Mamdouh Ahmed M. , Ng Shu Xuan , Sandhu Vedant , Jasdanwala Shaista Shabbir , Yilma Binyam , Bohl Stephan , Ryan Jeremy A. , Malani Disha , Luskin Marlise R. , Kallioniemi Olli , Porkka Kimmo , Adamia Sophia , Chng Wee Joo , Osato Motomi , Weinstock David M. , Garcia Jacqueline S. , Letai Anthony , Bhatt Shruti
Published: May 2024

Supplemental Figure 3 shows MDR mechanisms contribute to drug resistance in AML PDX models.
Supplementary Figures S1 - S11 from Human ASXL1-Mutant Hematopoiesis Is Driven by a Truncated Protein Associated with Aberrant Deubiquitination of H2AK119
Authors: Köhnke Thomas , Nuno Kevin A. , Alder Catherine C. , Gars Eric J. , Phan Paul , Fan Amy C. , Majeti Ravindra
Published: May 2024

Supplementary Figure 1: Overview of Stanford cohort. Supplementary Figure S2. Pooled screening of ASXL1 coding sequence. Supplementary Figure S3. Detection of truncated ASXL1 in CRISPR/Cas9-edited HSPCs. Supplementary Figure S4. Myeloid differentiation and in vitro proliferation assays. Supplementary Figure S5. Phenotyping of ASXL1 Trunc-derived myeloid malignancies. Supplementary Figure S6. H2AK119Ub in HSPC subsets. Supplementary Figure S7. Generation and phenotyping of corrected K562 cell line, BAP1 deletion and overexpression. Supplementary Figure S8. Consistent pattern of H2AK119Ub distribution dependent on PR-DUB activity. Supplementary Figure S9. Correlation of Gene Set enrichment with H2AK119Ub, ATAC-Seq and RNA-Seq. Supplementary Figure S10. Validation and phenotyping of inducible expression of truncated ASXL1 in K562 cells. Supplementary Figure S11. Inducible knockdown of RING1A and RING1B.
Table S5 from De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression
Authors: Tangudu Naveen Kumar , Buj Raquel , Wang Hui , Wang Jiefei , Cole Aidan R. , Uboveja Apoorva , Fang Richard , Amalric Amandine , Yang Baixue , Chatoff Adam , Crispim Claudia V. , Sajjakulnukit Peter , Lyons Maureen A. , Cooper Kristine , Hempel Nadine , Lyssiotis Costas A. , Chandran Uma R. , Snyder Nathaniel W. , Aird Katherine M.
Published: May 2024

31 common genes identified in screens and publicly available data
Disparities in Access to Deep Brain Stimulation for Parkinson’s Disease and Proposed Interventions: A Literature Review
Authors: Bishay Anthony E. , Hughes Natasha C. , Zargari Michael , Paulo Danika L. , Bishay Steven , Lyons Alexander T. , Morkos Mariam N. , Ball Tyler J. , Englot Dario J. , Bick Sarah K.
Published: May 2024

Background: Deep brain stimulation (DBS) is an effective therapy for Parkinson’s disease (PD), but disparities exist in access to DBS along gender, racial, and socioeconomic lines. Summary: Women are underrepresented in clinical trials and less likely to undergo DBS compared to their male counterparts. Racial and ethnic minorities are also less likely to undergo DBS procedures, even when controlling for disease severity and other demographic factors. These disparities can have significant impacts on patients’ access to care, quality of life, and ability to manage their debilitating movement disorders. Key Messages: Addressing these disparities requires increasing patient awareness and education, minimizing barriers to equitable access, and implementing diversity and inclusion initiatives within the healthcare system. In this systematic review, we first review literature discussing gender, racial, and socioeconomic disparities in DBS access and then propose several patient, provider, community, and national-level interventions to improve DBS access for all populations.
Safety, Efficacy, and Cost-effectiveness of Organ Suspension in Laparoscopic Gynecologic Surgery: A Retrospective Cohort Study to Validate an Innovative Technique: Laparoscopic Organ Suspension sec. Angioni
Authors: Angioni Stefano , Saponara Stefania , D'Ancona Gianmarco , Sicilia Gilda , D'Alterio Maurizio Nicola , Vitale Salvatore Giovanni
Published: May 2024

Objectives: This study aims to evaluate the safety, efficacy, and cost-effectiveness of the Laparoscopic Organ Suspension (OS) sec. Angioni, an innovative approach to transient OS in laparoscopic gynecological procedures. Recognizing the need to enhance surgical site access and overcome limitations of existing organ retraction methods, the study investigates a novel, in-theater constructed OS device. Design: This retrospective observational study was conducted from March 2019 to May 2021 and included 330 patients who underwent multiport or single-site-port laparoscopic surgery employing Angioni’s technique for transient pelvic OS. Participants/Materials, Setting, Methods: Participants included individuals undergoing surgery for conditions such as endometriosis, ovarian cancer, endometrial cancer, pelvic prolapse, and benign ovarian cysts. The Laparoscopic OS sec. Angioni utilizes a segment of a Foley catheter connected to a Polyglactin suture to provide adjustable tension, minimizing the need for reconfiguration during surgery. Results: The application of this OS technique resulted in an average suspension time of 1.9 min, with no significant difference between senior and junior surgeons. The method proved more time-efficient for posterior peritoneum suspension than other published methods and showed no additional risks of organ damage, bleeding, conversion to laparotomy, or OS-related complications. The secondary outcomes revealed reduced hospital stays and minimal blood loss, highlighting the procedure’s overall efficiency. Limitations: Given its retrospective and single-center nature, the study’s results may not be widely generalizable. Prospective multicentric comparative studies are recommended to further validate Angioni’s technique. Conclusions: Laparoscopic OS sec. Angioni is introduced as a straightforward, safe, and cost-effective method that significantly streamlines the surgical process. Its adaptability and ease of use suggest that it could be a valuable addition to current gynecological surgical practices, with potential implications for increasing efficiency and reducing procedural costs. Future studies are required to confirm these results across diverse clinical environments.
Lived Experiences of Novice Secondary School English Teachers in the Implementation of Modular Distance Learning in the Philippines
Authors: Miranda Criscel C. , Miranda Khif Muamar M. , Pongos Leonardo B.
Published: May 2024

As COVID-19 forced schools to shift to distance learning, the modular approach, in particular, became the most viable option for the continuity of learning. However, these sudden changes also brought unique experiences to novice teachers. This study explored the lived experiences of novice secondary school English teachers (NSSET) in Tagum City in implementing modular distance learning (MDL) in the context of the pandemic. Phenomenological inquiry based on Bronfenbrenner's ecological theory was used to explain the experiences of the eight (8) participants. Using validated researcher-made interview questions, virtual in-depth interviews were conducted. Through Braun and Clarke’s (2006) six-step framework, themes that emerged, categorized into five echelons, are as follows: poor cooperation of parents and students, and productive collaboration with colleagues and immediate heads; overwhelming pressure from external sources, and taking direction from others’ influence; perpetual communication breakdown, and confronting challenges in the delivery of modular learning; meeting society’s expectations; abrupt adjustment to the new normal. These shape the experiences of the NSSET in conducting MDL in the new normal. However, the poor cooperation of parents and students poses the most significant experience for the NSSET. Notwithstanding, novice teachers navigated successfully through these experiences brought about by implementing MDL amid the pandemic.
Pengelolaan Lahan di Kebun Jeruk
Authors: Prasetya Budi , Soemarno S , Hanuf Atiqah Aulia , Purwanti Nelsa Kumala Dewi , Dethan Albert Johanson
Published: May 2024

Kualitas tanah dapat dimaknai sebagai kapasitas tanah untuk berfungsi, sambil mempertahankan kualitas lingkungan dan meningkatkan kesehatan tanaman. Hal ini juga mengacu pada kemampuan tanah untuk berfungsi pada saat ini dan di masa depan untuk jangka waktu yang tidak terbatas. Kualitas tanah merupakan konsep dasar dalam pengelolaan berkelanjutan dari setiap sistem pertanian yang bertujuan untuk menghasilkan, menghindari atau mengurangi efek negatif terhadap lingkungan, melestarikan sumber daya dan menghemat energi dalam jangka menengah atau panjang dan penilaiannya dapat dianggap sebagai sarana untuk evaluasi kelestarian lingkungan sistem pertanian. Buah jeruk organik semakin populer di kalangan konsumen buah jeruk di dunia saat ini. Ketika berbicara tentang buah jeruk “organik”, biasanya mengacu pada bagaimana pohon jeruk ditanam di kebun jeruk. Pertanian organik hanya menggunakan pengendalian hama dan pupuk alami dan tidak pernah menggunakan bahan agrokimia pembunuh gulma atau pembunuh hama-penyakit di kebun jeruk. Memilih untuk menerapkan pupuk organik ke kebun jeruk berarti memberi spektrum manfaat yang luas. Pupuk organik memiliki dampak yang pasti terhadap lingkungan dan dapat menyumbangkan hara yang dibutuhkan untuk pertumbuhan dan membantu tanaman mengatasi gangguan penyakit. Penggunaan pupuk organik dapat meningkatkan kesuburan tanah dalam jangka waktu yang lama. Selain itu, pupuk organik juga dapat memasok nutrisi tanaman penting lainnya dan memperbaiki karakteristik tanah dengan memasukkan bahan organik ke dalam tanah. Buku ini memberikan paparan kepada pembaca yang mencakup konsep dasar dan ruang lingkup kajian serta pengelolaan kebun jeruk yang berkelanjutan. Pemahaman konsep tanah pengelolaannya yang terintegrasi sebagai landasan pengelolaan lahan pertanian, pemahaman permasalahan, penyebab, dan perencanaan lahan. Dengan membaca buku ini diharapkan pembaca mampu memahami konsep pengelolaan lahan guna meningkatkan kualitas tanah dan produksi tanaman jeruk.
Formula Enteral: Makanan Cair untuk Pasien dengan Tube Feeding
Authors: Harti Leny Budhi
Published: May 2024

Formula Enteral merupakan makanan cair yang diberikan kepada pasien yang mendapatkan makanan melalui selang/ sonde/ tube feeding. Tujuan pemberian formlua enteral adalah untuk memenuhi kebutuhan zat gizi pasien, sehingga menurunkan resiko terjadinya malnutrisi. Buku ini membahas lebih dalam terkait formula enteral, mulai dari sejarah formula enteral, konsep enteral nutrition, formula enteral itu sendiri, formula enteral blenderized, dan resep formula enteral blenderized.
Cisticercose do sistema nervoso central
Authors: Canelas Horacio Martins
Published: May 2024

A incidência da neurocisticercose (NC) reflete o grau de desenvolvimentodas nações ; em São Paulo, a freqüência de NC atinge a cifra média de 0,5%. O autor frisa a semelhança dos quadros neurológicos determinados pela cisticercose racemosa basilar e pela cenurose. São analisados, a seguir, os modos de infestação do sistema nervoso pelos cisticercos e as reações que nele desencadeiam. As formas clínicas são classificadas pelo autor em: hipertensivas, convulsivas, e formas com predomínio das manifestações neurológicas focais, que, quando associadas à síndrome hipertensiva, configuram as modalidades pseudotumorais.É salientada a importância das alterações do líquido cefalorraqueano (presença de células eosinófilas e positividade da reação de fixação de complemento), que permitiram o diagnóstico de NC em 86,5% dos 296 casos da Clínica Neurológica da Faculdade de Medicina da USP. O craniograma revelou calcificações micronodulares em 19,9% dos casos. É analisado o valor dos exames neurorradiológicos para o esclarecimento da patogenia das formas hipertensivas.É rara a regressão espontânea de NC ; nas formas subagudas ou crônicas, o tratamento medicamentoso (sulfas e corticóides) pode proporcionar resultados satisfatórios; nas formas hipertensivas é necessário, por vezes, apelar para a neurocirurgia. O prognóstico da NC ainda é muito reservado. A mortalidade geral atingiu a cifra de 24,7%. O problema da N C clama por uma solução profiláctica: a infestação dos rebanhos suínos deve constituir o primeiro alvo de combate; quanto ao homem, devem-se instituir campanhas de Saúde Pública visando à prevenção da teníase.
Litíase reno ureteral: (tratamento)
Authors: Borrelli Milton
Published: May 2024

O autor focaliza aspectos gerais relacionados com a etiopatogenia da litíase reno-ureteral, dando destaque ao problema do tratamento.
Semiologia urológica
Authors: Srougi Michel , Nápoli Francisco , Góes Gilberto Menezes de
Published: May 2024

Os autores apresentam os principais sintomas e sinais referidos pelos pacientes urológicos e descrevem de maneira sistemática o exame físico desses pacientes, no que se refere ao aparelho urogenital. De uma maneira geral, tentou-se correlacionar os sintomas e sinais com as principais patologias que acometem o sistema urinário e o trato genital masculino.
Effects of Recombinant Human Lecithin Cholesterol Acyltransferase on Lipoprotein Metabolism in Humans
Authors: Reyes-Soffer Gissette , Matveyenko Anastasiya , Lignos James , Matienzo Nelsa , Santos Baez Leinys S. , Hernandez-Ono Antonio , Yung Lau , Nandakumar Renu , Singh Sasha A. , Aikawa Masanori , George Richard , Ginsberg Henry N.
Published: May 2024

BACKGROUND:

LCAT (lecithin cholesterol acyl transferase) catalyzes the conversion of unesterified, or free cholesterol, to cholesteryl ester, which moves from the surface of HDL (high-density lipoprotein) into the neutral lipid core. As this iterative process continues, nascent lipid-poor HDL is converted to a series of larger, spherical cholesteryl ester–enriched HDL particles that can be cleared by the liver in a process that has been termed reverse cholesterol transport.

METHODS:

We conducted a randomized, placebocontrolled, crossover study in 5 volunteers with atherosclerotic cardiovascular disease, to examine the effects of an acute increase of recombinant human (rh) LCAT via intravenous administration (300-mg loading dose followed by 150 mg at 48 hours) on the in vivo metabolism of HDL APO (apolipoprotein)A1 and APOA2, and the APOB100-lipoproteins, very low density, intermediate density, and low-density lipoproteins.

RESULTS:

As expected, recombinant human LCAT treatment significantly increased HDL-cholesterol (34.9 mg/dL;
P
≤0.001), and this was mostly due to the increase in cholesteryl ester content (33.0 mg/dL;
P
=0.014). This change did not affect the fractional clearance or production rates of HDL-APOA1 and HDL-APOA2. There were also no significant changes in the metabolism of APOB100-lipoproteins.

CONCLUSIONS:

Our results suggest that an acute increase in LCAT activity drives greater flux of cholesteryl ester through the reverse cholesterol transport pathway without significantly altering the clearance and production of the main HDL proteins and without affecting the metabolism of APOB100-lipoproteins. Long-term elevations of LCAT might, therefore, have beneficial effects on total body cholesterol balance and atherogenesis.
Intermittent Fasting After ST-Segment–Elevation Myocardial Infarction Improves Left Ventricular Function: The Randomized Controlled INTERFAST-MI Trial
Authors: Dutzmann Jochen , Kefalianakis Zoe , Kahles Florian , Daniel Jan-Marcus , Gufler Hubert , Wohlgemuth Walter Alexander , Knöpp Kai , Sedding Daniel G.
Published: May 2024

BACKGROUND:

Intermittent fasting has shown positive effects on numerous cardiovascular risk factors. The INTERFAST-MI trial (Intermittent Fasting in Myocardial Infarction) has been designed to study the effects of intermittent fasting on cardiac function after STEM (ST-segment–elevation myocardial infarction) and the feasibility of future multicenter trials.

METHODS:

The INTERFAST-MI study was a prospective, randomized, controlled, nonblinded, single-center investigator-initiated trial. From October 1, 2020, to July 15, 2022, 48 patients were randomized to the study groups intermittent fasting or regular diet and followed for 6 months with follow-up visits at 4 weeks and 3 months.

RESULTS:

In all, 22 of 24 patients in the intermittent fasting group with a mean age of 58.54±12.29 years and 20 of 24 patients in the regular diet group with a mean age of 59.60±13.11 years were included in the intention-to-treat population. The primary efficacy end point (improvement in left ventricular ejection fraction after 4 weeks) was significantly greater in the intermittent fasting group compared with the control group (mean±SD, 6.636±7.122%. versus 1.450±4.828%;
P
=0.038). This effect was still significant and even more pronounced after 3 and 6 months. The patients in the intermittent fasting group showed a greater reduction in diastolic blood pressure and body weight compared with the control group. The mean adherence of patients in the intermittent fasting group was a median of 83.7% (interquartile range, 69.0%–98.4%) of all days. None of the patients from either group reported dizziness, syncope, or collapse.

CONCLUSIONS:

Our results suggest that intermittent fasting after myocardial infarction may be safe and could improve left ventricular function after STEMI.

REGISTRATION:

URL:
https://www.drks.de
; Unique identifier: DRKS00021784.
Taking the Fact/Law Distinction Not Too Seriously: the Status of Domestic Law within International Litigation
Authors: El Boudouhi Saïda
Published: May 2024

The article uses legal theory relating to the traditional distinction between fact and law in order to shed light on the procedural consequences of the consideration that domestic law is a fact in international law. The analysis first relies on formalism, and on the legal syllogism doctrine more specifically, to show that domestic law cannot be, in most cases, anything else than a fact in international legal reasoning. It then draws attention to a constructivist approach to facts according to which domestic law is subject to assessment and interpretation as any other fact is in the judicial process. It paves the way to understanding that the distinction between fact and law for the purposes of the scope of review in the WTO dispute settlement system, as in other appellate systems, is purely functional and must not be taken too seriously, contrary to what is suggested by some analyses of the practice.
When Yiddish Was Written in Latin Letters
Authors: Cohen Roman Oren
Published: May 2024

Although Yiddish was traditionally written in Hebrew letters, texts in this language were also recorded using Latin characters in various circumstances, times, and places. These texts offer valuable information regarding pronunciation traditions and shed light on the processes of cultural history and sociolinguistics that acted as catalysts to their preparation. Various studies have discussed this phenomenon, yet they usually focus on one specific reason for using the Latin alphabet, such as ideological Romanization or linguistic adequacy. The following article offers for the first time a descriptive survey of the entire corpus, from the Early Modern Era to the present day. Paying close attention to the orthography used and the variety recorded, this article discerns within the studied corpus distinct categories reflecting the religious, linguistic, and ideological backgrounds of the texts’ authors and intended readers as well as technical factors pertaining to print. It also highlights the crucial role of the Hebrew alphabet in Yiddish culture.
A new species of the Centaurea busambarensis complex (Asteraceae) from the Nebrodi Mountains in Sicily (Central Mediterranean region)
Authors: GIANGUZZI LORENZO , DI GRISTINA EMILIO , BARONE GIULIO , DOMINA GIANNIANTONIO
Published: May 2024

A new population of Centaurea, belonging to the C. busambarensis complex, was recently discovered in the Nebrodi Mountain (northeastern Sicily). Individuals of this population show some peculiar characters differentiating it from the nine currently recognized species of the C. busambarensis complex in Sicily. To validate this differentiation, we conducted a statistical analysis on the morphological characters. The results indicated that this new population is sufficiently distinct to deserve recognition as a separate species. In this context, we provide a detailed description and illustrations of the newly identified species, which we name C. haluntina. This new species is a punctiform endemic to the lower Nebrodi Mountains.
A Framework for Constraining Ocean Mixing Rates and Overturning Circulation from Age Tracers
Authors: Zhang Boer , Linz Marianna , Sun Shantong , Thompson Andrew F.
Published: May 2024

The age of seawater refers to the amount of time that has elapsed since that water encountered the surface. This age measures the ventilation rate of the ocean, and the spatial distribution of age can be influenced by multiple processes, such as overturning circulation, ocean mixing, and air–sea exchange. In this work, we aim to gain new quantitative insights about how the ocean’s age tracer distribution reflects the strength of the meridional overturning circulation and diapycnal diffusivity. We propose an integral constraint that relates the age tracer flow across an isopycnal surface to the geometry of the surface. With the integral constraint, a relationship between the globally averaged effective diapycnal diffusivity and the meridional overturning strength at an arbitrary density level can be inferred from the age tracer concentration near that level. The theory is tested in a set of idealized single-basin simulations. A key insight from this study is that the age difference between regions of upwelling and downwelling, rather than any single absolute age value, is the best indicator of overturning strength. The framework has also been adapted to estimate the strength of abyssal overturning circulation in the modern North Pacific, and we demonstrate that the age field provides an estimate of the circulation strength consistent with previous studies. This framework could potentially constrain ocean circulation and mixing rates from age-like realistic tracers (e.g., radiocarbon) in both past and present climates.

Significance Statement

The age of seawater—the local mean time since local water from different pathways was last at the surface—is a valuable indicator of ocean circulation and the transport time scale of heat and carbon. We introduce a novel constraint that relates total age flow across a density surface to its geometry, which provides new insights into constraining ocean circulation and mixing rates from age-like realistic tracers (e.g., radiocarbon).
Impact of Safety-Net Hospital Status on Immediate Reconstruction Following Mastectomy: A Contemporary National Analysis
Authors: Curry Joanna , Vadlakonda Amulya , Kim Shineui , Porter Giselle , Balian Jeff , Benharash Peyman , Thompson Carlie K.
Published: May 2024

Introduction

Immediate breast reconstruction (IBR) following mastectomy has been shown to improve quality of life and partially mitigate the adverse psychological impacts associated with the procedure. The present study examined hospital-based and patient-level disparities in utilization and outcomes of IBR following mastectomy.

Methods

All female adult hospitalizations with a diagnosis of breast cancer undergoing mastectomy were identified in the 2016 to 2020 National Inpatient Sample. Safety-net hospitals (SNH) were defined as those in the top quartile of all Medicaid or self-pay admissions. Patients who underwent mastectomy at SNH comprised the SNH cohort (others: Non-SNH). Multivariable models were developed to examine the impact of SNH status and patient factors on rates of IBR.

Results

Of an estimated 127,740 hospitalizations, 28,330 (22.2%) were treated at SNH. The proportion of patients receiving IBR increased from 46.7% in 2016 to 51.7% in 2020 (nptrend<.001). Compared to others, SNH were younger (57.9 ± 13.5 vs 58.3 ± 13.5 years) and less commonly White (45.6 vs 69.9%) (all P < .001). Additionally, SNH were more likely to receive unilateral mastectomy (67.1 vs 55.2%) but less frequently underwent IBR (37.7 vs 51.5%) (all P < .001). After adjustment, Black and Asian race, SNH, and bilateral mastectomy were associated with decreased odds of IBR. Increasing IBR hospital volume did not eliminate the observed racial disparity at non-SNH or SNH.

Conclusion

There are disparities in rates of IBR following mastectomy attributable to SNH status. Future work is needed to ensure all patients have access to reconstructive care irrespective of payer status or the hospital at which they receive care.
Acoustic and Articulatory Visual Feedback in Classroom L2 Vowel Remediation
Authors: Kocjančič Tanja , Bořil Tomáš , Hofmann Susanna
Published: May 2024

This paper presents L2 vowel remediation in a classroom setting via two real-time visual feedback methods: articulatory ultrasound tongue imaging, which shows tongue shape and position, and a newly developed acoustic formant analyzer, which visualizes a point correlating with the combined effect of tongue position and lip rounding in a vowel quadrilateral. Ten Czech students of the Swedish language participated in the study. Swedish vowel production is difficult for Czech speakers since the languages differ significantly in their vowel systems. The students selected the vowel targets on their own and practiced in two classroom groups, with six students receiving two ultrasound training lessons, followed by one acoustic, and four students receiving two acoustic lessons, followed by one ultrasound. Audio data were collected pre-training, after the two sessions employing the first visual feedback method, and at post-training, allowing measuring Euclidean distance among selected groups of vowels and observing the direction of change within the vowel quadrilateral as a result of practice. Perception tests were performed before and after training, revealing that most learners perceived selected vowels correctly already before the practice. The study showed that both feedback methods can be successfully applied to L2 classroom learning, and both lead to the improvement in the pronunciation of the selected vowels, as well as the Swedish vowel set as a whole. However, ultrasound tongue imaging seems to have an advantage as it resulted in a greater number of improved targets.
Change in Administration, Change in Deportation Worry? Analyzing the Reduction of U.S. Latinos’ Worries About Deportation from 2019 to 2021
Authors: Díaz McConnell Eileen , Martinez Lisa M.
Published: May 2024

Extensive scholarship traces the development and impacts of the U.S. immigration and deportation system on Latino immigrants and U.S. born Latinos, alike. However, relatively little quantitative research has investigated the worries that Latinos express about deportation, explored the temporal dynamics in such concerns, or identified which factors predict shifts in deportation-related concerns over time. Using two waves of data for a national sample of U.S. Latino adults, the analyses explored changes in their deportation worry between 2019 and 2021, marking the transition from the Trump administration to the Biden administration. Descriptive results indicate that more than a third of Latinos reported reductions in deportation worry over the two year period, with even larger proportions of Latino immigrants, including naturalized citizens, legal permanent residents and undocumented immigrants, reporting declines in worry. Regression results reveal that, aside from indicators of legal vulnerability, other aspects of the current sociopolitical and racialized context meaningfully shape declines in deportation worries. Specifically, darker-skinned Latinos, and those experiencing more anti-Hispanic discrimination, expressing some co-ethnic linked fate, and who viewed the Trump administration as harmful to Latinos reported significant reductions in worry from 2019 to 2021, ceteris paribus. These results suggest a “calming effect” of some Latinos’ deportation worries as the Trump administration ended and the Biden administration began. Nevertheless, the study demonstrates how the racialized immigration and deportation system shapes deportation-related worries among a wide swath of Latinos, the consequences of which racialize them and spill over into their everyday lives.
The importance of promoting critical thinking in schools: Examples from Germany
Authors: Rott David , Kohnen Marcus , Fischer Christian
Published: May 2024

Critical thinking is internationally recognized as an important aspect of school education. Particularly in the United States, Scandinavian, and Asian countries, critical thinking is firmly anchored in school curricula. In this context, critical thinking is often aligned with critical thinking skills, which can be taught in structured programs and are comparable to strategies for self-regulated learning. Unlike in the United States, in German-speaking countries, critical thinking is a buzzword in pedagogical debates and is not firmly embedded in instructional contexts. There are desiderata for the entire educational system (theoretical, empirical, and school-practical). In the context of gifted education, development projects place a particular focus on the possibilities of design and investigation. Two projects will be presented, as well as exemplary implementation possibilities relevant to schools’ diagnostic and didactic processes. The projects will be related to each other, and research perspectives are given.
Navigating work-family conflict, entrepreneurial passion, and entrepreneurial exit intention amidst the COVID-19 pandemic in Shanghai
Authors: Wang Jiabao , Zhao Yi
Published: May 2024

Drawing upon the Conservation of Resources (COR) theory, this study examines the relationship between Work-Family Conflict (WFC) and entrepreneurial exit intention, as well as the mediating role of entrepreneurial passion and the moderating role of external relationship embedding, in the context of the pandemic in Shanghai. Based on Structural Equation Modeling (SEM) and data at multiple time points from 389 entrepreneurs, results indicate that there is a positive relationship between WFC and entrepreneurial exit intention among entrepreneurs during the pandemic. Entrepreneurial passion plays a critical mediating role between WFC and entrepreneurial exit intention through the lens of resource loss. External relationship embedding, as a vital external resource provider, plays a moderating role in the relationship between WFC and entrepreneurial passion. It also moderates the mediating role of entrepreneurial passion in the relationship between WFC and entrepreneurial exit intention. Overall, this research broadens the existing COR theory from the perspective of resource gains and losses and investigates the complicated interplay between WFC, entrepreneurial outcomes, and external relationship networks. Theoretical and practical implications are discussed in this work.
Dreamtelling: The value of dreaming and sharing dreams in relations: Part II: The practice of a group analytic approach to shared dreams
Authors: Friedman Robi
Published: May 2024

After having described communicational and relational characteristics of dreaming and sharing dreams, in Part II, I provide deeper exploration of a clinical example in group-analytic group therapy, describing group work with a dream. The uniqueness of the group-analytic approach to the dream’s contents and its communicative aspect will be stressed. Requests for containment preoccupy relations and participants and should be elaborated during the discourse of ‘dreamtelling’.
Comment on ‘Sexual relationships in group analysis: Theoretical investigations and clinical applications’ by Anastassios Koukis
Authors: Haude Volker
Published: May 2024

With respect to the article by Koukis (2024) the author questions important points concerning self-exclusion, working through, external group events, boundary incidents and bodily experience. He concludes that it is necessary to restore boundaries and facilitate the therapeutic space.
Historic Preservation in Legacy City Comprehensive Plans
Authors: Ryberg-Webster Stephanie R. , Kinahan Kelly
Published: May 2024

This paper focuses on the ways in which recent comprehensive planning efforts in legacy cities address issues of historic preservation. Using 15 comprehensive plans as archival sources, we conduct textual analysis to explore how each of the plans incorporates historic preservation. The findings confirm existing research that suggests historic preservation has grown into an integral component of city planning efforts. The research offers insights into the current relationship between preservation and city planning, particularly within the context of legacy cities, and suggests that, despite recent practice, preservation remains a more palatable strategy than widespread demolition.
Consequences of COVID-19 Vaccine Hesitancy Among Healthcare Providers During the First 10 Months of Vaccine Availability: Scoping Review
Authors: Wilpstra Caitlyn D. , Morrell Sherry , Mirza Noeman A. , Ralph Jody L.
Published: May 2024

Background

Throughout the COVID-19 pandemic, healthcare providers (HCPs)—including nurses—have played important roles in the vaccination effort. It is expected that COVID-19 vaccine hesitancy among HCPs has numerous consequences; however, the scope of these consequences and their impacts on providers, patients, and the broader healthcare system remained unclear.

Purpose

To identify existing and emerging evidence to understand the state of knowledge of the consequences of COVID-19 vaccine hesitancy among HCPs.

Methods

A scoping review was completed based upon the JBI scoping review methodology. The databases searched included OVID Medline, EBSCOhost CINAHL, ProQuest Nursing and Allied Health Source, ProQuest APA PsycInfo, and ProQuest Dissertations and Theses. The final literature search was completed on June 2, 2022. Studies were screened and retrieved based on predefined inclusion and exclusion criteria using Covidence reference management software. Data extraction followed criteria recommended in the JBI scoping review framework with additional relevant variables identified by the authors.

Results

A total of 33 sources were included in the review. Consequences of HCP COVID-19 vaccine hesitancy were grouped under three themes and seven subthemes. Consequences affecting HCPs included health-related, psychosocial, and employment-related consequences. Consequences affecting patients pertained to COVID-19 vaccination communication and COVID-19 vaccination practices of HCPs. Consequences to the healthcare system involved consequences to coworkers and employment/attendance/staffing-related consequences.

Conclusions

Healthcare provider COVID-19 vaccine hesitancy was found to have numerous consequences. By understanding the scope and extent of these consequences, healthcare leaders, researchers, and HCPs can work together to protect providers, patients, and healthcare systems.
Saliva Malondialdehyde Concentration of Dogs With and Without Periodontal Disease
Authors: Schroers M. , Reiser K. , Alexander T. , Zablotski Y. , Meyer-Lindenberg A.
Published: May 2024

The study investigated whether malondialdehyde (MDA), a biomarker for oxidative stress, can be used as a viable parameter in dog saliva for the diagnosis or early detection of periodontal disease (PD). Saliva MDA concentrations were measured preoperatively in dogs diagnosed with PD during dental prophylaxis and compared with those of dentally healthy dogs. 35 dogs were included in the study. The average MDA concentration was 270 ng/ml (range 27-633) in the dogs without PD (n = 10) and 183 (36-833) ng/ml (ng/ml) in the dogs with PD (n = 25). The maximum MDA concentration in the study group (PD ≥1) was 833 ng/ml, which was significantly higher than in the study group (PD = 0) (p<0.05). The study showed that salivary MDA concentrations could not distinguish between healthy dogs and those with PD.
Multi-agency counter-terrorism in Britain and Norway: Intelligence agencies and the administration of welfare
Authors: Heath-Kelly Charlotte
Published: May 2024

This article explores the emergence of new counter-terrorism programmes in the Britain and Norway through which intelligence and security agencies administer welfare. Support and resources are covertly allocated to persons identified as potential threats, through multi-agency structures led by intelligence and security agencies. Unlike Countering Violent Extremism programmes, this multi-agency management is not led by the local municipality; nor are its participants asked to consent to participation. These new programmes are covert. To conceptualize the significance of intelligence agencies entering the space of welfare administration, Mitchell Dean’s work ‘Liberal Government and Authoritarianism’ is used to underline the traditional separation of agencies within liberal governmentality. Governing through freedom entails the ostensible separation of policing, education and care agencies – reflecting the categorization of the population into groups requiring varying levels of coercion to self-govern. To avoid governing too much, each category of population is allocated a specific agency. Traditionally, intelligence and security agencies have been positioned at the highest tier of repression. By entering the space of welfare administration (and thus social policy), intelligence and security agencies have disturbed the sectoral separation integral to liberal governmentality, leaving care and repression in an ever more ambiguous relationship.
New Patterns of Community Care: Coordinated Services for Dually Diagnosed Adults in North Carolina
Authors: Polgar Michael F. , Johnsen Matthew C. , Starrett Barbara E. , Fried Bruce J. , Morrissey Joseph P.
Published: May 2024

North Carolina has developed coordinated care systems for people dually diagnosed with both a mental retardation and a different major mental illness. In response to a class action lawsuit, the state has become a leader in treatment of this form of dual diagnosis. Systems of care for this “Thomas S class” operate in each of 41 area programs for mental health, developmental disabilities, and substance abuse. Networks of care among leaders in mental health and developmental disability promote the coordination of health, housing, social, and vocational services. A survey of 100 area program leaders finds extensive cooperation and a variety of services provided and contracted for, both within and beyond each area program, particularly among developmental disability specialists. Cooperation among leaders is associated with service variety and inter-organizational linkages. The extent of relationships among provider organizations is associated with better access to care. Best practice includes a single portal of entry and inter-agency councils.
The Interests of Three Stakeholders in Independent Personal Care for Disabled Elders
Authors: Keigher Sharon M.
Published: May 2024

There is concern throughout developed countries about how sufficient services can be mounted in this century to care for all older, disabled persons who want to remain at home. With declining availability of family care and high turnover among paid workers, cost, care supply, and quality dilemmas abound. Therefore, how can home care be improved? One suggestion is to revise the care “contract” by simply eliminating the costly bureaucratic and controlling dimensions of agency oversight and management.

In consumer-directed or self-managed care, independent workers are hired directly by consumers or their family members. Consumers spend their own private money or government provides authorization for them to “hire” their own workers. Such arrangements may be more responsive to the needs of consumers, more directly accountable to them, and less costly for both individuals and government.

This article examines 41 cases of consumer-directed care in Milwaukee. Extended interviews with three “stakeholders” in care—the disabled, older client, the family caregiver, and the personal assistant—were conducted, including both private pay and government subsidized arrangements. This analysis identifies some essential, but disparate interests of the three partners in care.
The Regulation of Outpatient — Services: An Analysis of the Interaction Between HCFA and Medicare Providers
Authors: Weingarten Joseph P.
Published: May 2024

The Federal Register is used as a historical record documenting the interaction between the Health Care Financing Administration (HCFA) and health care providers in the regulation of outpatient surgery services to Medicare patients. A content analysis of the Federal Register reveals that HBFA is more likely to accommodate requests for clarification, for shifting services among payment levels, and for adding or deleting services from coverage than for altering payment methods. These findings ca be used by health care providers to develop strategies for coping with the expansion of prospective payment to all outpatient services.
HIV Transmission Risks of Females and Males in Paired Partner Relationships
Authors: Sly David F. , Harrison Dianne F. , Moore Trent W. , Soler Hosana
Published: May 2024

As the HIV/AIDS epidemic has evolved. heterosexual behaviors have come to be an increasingly important mode of transmission and rates of infection have increased faster among women generally and minority women in particular. Most of what we know about heterosexual risk taking is based on survey data collected from either women or nan. These data have been useful for helping to understand different levels and types of risk taking by women and men. However. they provide little information about the levels of risk taking that exist for paired partners in main partner relationships, the types of risks each partner brings to the relationship and how the contribution of partner risks varies. Using data from the pretest of a pilot project designed to test a behavioral intervention to reduce HIV/AIDS transmission among main sex partners, the authors developed four subscales of sexual risk taking for each partner. The association between subscales within and between genders are examined and the subscales are combined to obtain measures of couple risks. Particular attention is given to the gender contribution of partners to couple risk and the differential contribution of types of risk to total risk. The data suggest that, even though men bring relatively higher risks to their main partner relationship than women, this varies inversely with the level of couple risk.
Population Movements and the Spread of HIV/AIDS in Mozambique
Authors: Foreit Karen F. , Averting T.E. , Barreto P. , Isabel Antonio Noya , Nhatave
Published: May 2024

This article demonstrates how the spread of HIV AIDS in Mozambique may gave been affected by internal and external population movements which, in turn, contributed to the pronounced regional differences in adult HIV prevalence among the three regions of the country observed today. Further population movement may put certain individuals at higher risk ot HIV infection but, even if these movements were to stop, in the absence of effective interventions to prevent new infections, HIV prevalence would remain high and perhaps continue to rise. The current regional differences in HIV prevalence and duration of the epidemic present different challenges for the development and implementation of prevention and mitigation services.
Navigating Nigeria’s Health Landscape: Population Growth and Its Health Implications
Authors: Adesola Ridwan Olamilekan , Opuni Emmanuel , Idris Ibrahim , Okesanya Olalekan John , Igwe Ogechukwu , Abdulazeez Modinat Dasola , Lucero-Prisno Don Eliseo
Published: May 2024

This comprehensive analysis examines the multifaceted impacts of population growth on public health in Nigeria. Drawing parallels with Omran’s epidemiological transition model (that focuses on the intricate means that patterns of health and illness are changing, as well as the relationships that exist between these patterns and the sociological, demographic, and economic factors that influence them) and referencing experiences from Chile and Ceylon. The study highlights a substantial rise in Nigeria’s population causing a double burden of infectious and non-communicable diseases, leading to higher morbidity, and mortality rates, increased healthcare costs, decreased productivity, and health inequalities, posing significant challenges to the country’s healthcare system. Furthermore, the correlation between low education levels and health outcomes underscores the importance of addressing systemic deficiencies in Nigeria’s educational sector. The article emphasizes the urgent need for strategic interventions to mitigate the adverse effects of population growth on health. Recommendations include revitalizing primary healthcare centers, fostering public-private partnerships to enhance healthcare accessibility, leveraging technological advancements like telemedicine, and promoting initiatives to improve nutrition and environmental sustainability. Moreover, prioritizing education on reproductive health and family planning emerges as a crucial strategy to manage population growth sustainably. In conclusion, the article underscores the imperative for collaborative efforts across sectors to navigate Nigeria’s evolving health landscape amidst increasing population growth. By implementing targeted policies and interventions, Nigeria can strive toward achieving universal health coverage, enhancing health outcomes, and ultimately raising the standard of living for its populace.