bluuebunny/crossref_metadata_2025 huggingface dataset:
Một số giá trị địa chất - cảnh quan vùng Cao Nguyên đá Đồng Văn - Mèo Vạc đáp ứng xây dựng Công viên Địa cảnh (Geopark)
Authors: Phương Tạ Hòa , Bào Đặng Văn , Vượng Nguyễn Văn , Minh Vũ Cao , Lực Phạm Văn
Published: July 2019

Some geological values of Dong Van - Meo Vac rockyr highland in term of geopark creation
Tai biến trượt lở sờn tại thị xã Hà Giang và vấn đề cảnh báo
Authors: An Lê Đức , Khanh Uông Đình , Tuấn Tống Phúc , Thành Nguyễn Ngọc
Published: July 2019

Landslide hazard in Ha Giang town and problem of prediction
Sự tái nhiễm từ trên các thành tạo trầm tích Devon vùng Quảng Bình
Authors: Lan Lưu Thị Phương
Published: July 2019

Remagnetization of Devonian rocks in Quang Binh
Kết quả hiệu chuẩn và xác định hệ số khuếch đại của thiết bị ghi địa chấn tại các trạm địa chấn Việt Nam
Authors: Lư Ngô Thị
Published: July 2019

Results of the calibration and determinations of amplification factor of recording equipments at seismic stations of Vietnam
Dấu hiệu các bờ biển cổ ở đáy biển nông ven bờ Bắc Trung Bộ vỡ tiềm năng sa khoáng liên quan
Authors: Phúc La Thế , Sơn Vũ Trường
Published: July 2019

Traces of the buried Late Pleistocene ancient coastline in the coastal shallow bed of the North Central part of Vietnam and associated placer potential
Hiệu chỉnh công thức tính độ sâu tổn thất ban đầu trong phương pháp SCS bằng thực nghiệm số cho lưu vực sông Tả Trạch (trạm Thượng Nhật)
Authors: Sơn Nguyễn Thanh
Published: July 2019

Calibration of initial head loss formula in the SCS method using numerical experiments for the Ta Trach River basin, Thuong Nhat Station
Một số kết quả bước đầu nghiên cứu cấu trúc móng trước Kainozoi khu vực Tp Hồ Chí Minh và kế cận trên cơ sở tài liệu trọng lực
Authors: Triều Cao Đình , Dũng Lê Văn , Hưng Phạm Nam , Bách Mai Xuân , Tuyên Nguyễn Hữu , Tuấn Thái Anh , Nam Bùi Anh
Published: July 2019

Primary results of studying the Pre-Cenozoic basement structure of Ho Chi Minh City on the basis of Bouguer gravity anomalies
Effect of Aging and Priming on Physiological and Biochemical Traits of Common Bean (Phaseolus vulgaris L.)
Authors: AMANPOUR-BALANEJI Bahman , SEDGHI Mohammad
Published: July 2019

Aging and deterioration (artificial aging) are the most effective factors on the seed vigour. In order to study the changes in physiological and biochemical characteristics of common bean under aging and priming treatments a factorial experiment based on completely randomized design conducted with three replications. Seed aging (control, 90 and 80% of control germination) and seed invigoration with priming including control, hydro (distilled water), osmo (PEG 6000), hormone (gibberellic acid) and halo (NaCl) priming were considered as experimental factors. Results showed that osmo-priming had the ability to relatively ameliorate the aging effect and recover some of the seed aspects like germination rate, protein and phytin content for invigorate germination and seedling establishment. Priming indirectly increased seed vigour via germination rate and it can provide homogeny of emergence in the field and obtaining appropriate plant population.
Anatomical Basis for Optimal Use of Water for Maintenance of Three Xerophytic Plants
Authors: ABDULRAHAMAN Abdullahi Alanamu , OLADELE Felix Ayotunde
Published: July 2019

Three xerophytic plant species namely Agave americana Linn., Aloe vera Tourn. and Linn. and Euphorbia milii Des Moul. were propagated in a greenhouse each with 5 varying soil moisture contents i.e. 1.25%, 2.5%, 5%, 10%, and 20% and subjected to 4 watering frequencies i.e. daily, weekly, biweekly and monthly. Euphorbia milii was the most xerophytic species having relatively lower rate of transpiration than Aloe vera and Agave americana. It was suggested that the high rate of transpiration in Aloe vera and Agave americana may be due to the large tetracytic stomata as compared to the small paracytic stomata of Euphorbia milii. It was also observed that Aloe vera was least tolerant of high soil moisture in daily watering as well as low soil moisture in monthly regime. Agave americana and Euphorbia milii were species that were more robust with capacity to cope well with low and high watering regimes than Aloe vera.
Intra-annual Secondary Growth Rate-Climate Relations of Fagus orientalis Lipsky in the Center of Hyrcanian Forests
Authors: OLADI Reza , POURTAHMASI Kambiz
Published: July 2019

Weekly rate of Beech tree ring increment were related to the changes of climatic factors in weekly intervals. In order to do so, small samples were extracted from 5 Oriental beech trees located in Nowshahr educational forest in the central part of the Hyrcanian forests of Iran during 2008 growing season. Microscopic sections were prepared and average increases in tree ring width were measured, standardized and modeled using Gompertz equation. The results showed that the minimum air temperature and water evaporation had the strongest and positive effect on the secondary growth rate while the role of precipitation was minor and negative. Air temperature and evaporation variations during growing season were assumed to remain in their optimum level; increasing xylem formation by accelerating carbohydrate production and carbon uptake of trees, respectively. Since the studied site had warm and humid climate receiving sufficient amount of rainfall before and during growing season, water availability was not a limiting factor of radial growth and its minor negative relation was interpreted according to its small hampering effect on the air temperature and sunlight absorption of trees. It was concluded that meteorological factors affecting secondary growth rate of trees should be interpreted as a package rather than analyzed disconnectedly.
Influence of Plant Growth Regulators (PGRs) and Planting Method on Growth and Yield in Oil Pumpkin (Cucurbita pepo var. styriaca)
Authors: SURE Shirzad , AROOIE Hosein , AZIZI Majid
Published: July 2019

The effect of plant growth regulators IBA (indole butyric acid), GA3 (gibberellin) and ethylene (as ethephon) in two methods of planting was investigated (each method was considered as a separate experiment) on morphological characters and yield of medicinal pumpkin. The experiments were carried out in a factorial trial based on completely randomized block design, with four replicates. The treatments were combined with priming and spraying with the above PGRs. The first seed priming with control (water), IBA 100 ppm, GA3 25 ppm and ethephon 200 ppm, and when seedling developed to 4 leaf stage sprayed there with control (water), IBA 100 ppm, GA3 25 ppm and ethephon 200 ppm for three times. In both planting methods, there were all of these treatments. The result showed that PGRs and planting method had significant effects on vegetative, flowering and yield characteristics including: leaf area %DM plant, number of male and female flowers per plant, number of fruit/plant, fruits fresh weight, seeds length and width, number of seed per fruit, seed yield, % seeds oil and oil yield. Hence spraying with GA3 25 ppm in four leaf stage at trellis method could be a suitable treatment for enhancing growth and yield of medicinal pumpkin.
Perception Comparisons of Special Education Teachers, Parents of Children with Disabilities, General Education Teachers, and Residents in Local Communities on Special Education Facilities
Authors:   The Korean Society of Special Education, Park Jaekook , Koh Hyejung , Park Yujeong
Published: July 2019

This study investigated the perception on special education facilities among four groups(i.e., special education teachers, parents of children with disabilities, general education teachers, and residents in local communities), aiming to explore a new approach to improve the understandings on the roles of special education facilities as well as their functions as learning communities. A survey was conducted and its results were as follows: First, regarding the necessity of having a special education facility in a community, all four groups showed positive perceptions. Second, parents believed that special education schools can rebuild the local communities in a positive way, whereas residents showed relatively negative perceptions on the roles of special education schools. Third, there were some differences between the four groups in their responses on the communication route to making a decision; parents showed higher scores on the roles of local government than other groups, whereas residents put more emphasis on the roles of local referendum system. Lastly, residents had lower expectations on the new roles of a community-based special education facility, particularly regarding to sharing school related facilities and participating in educational program. Based on the results, the implications and future directions for research were discussed.
FUNCTIONAL IMPROVEMENT AFTER PERCUTANEOUS NEPHROLITHOTOMY IN THE SOLITARY KIDNEY PATIENTS
Authors: Ahmed Hthayyim , Hassan Mohammed , Mahmood Sarwar , Aghaways Ismaeel , Ghareeb Rawa , Khurshid Dlshad
Published: July 2019

Background 

Percutaneous nephrolithotomy is regarded as the treatment of choice for large and complex renal stones. Despite of its safety and efficacy, it remains a crucial challenge for endourologist in soiltary kidney patients

Objectives 

To assess the effect of percutaneous nephrolithotomy (PNL) on renal function measured by glomerular filtration rate (GFR) in solitary kidney patients

Materials and Methods

The records of 25 patients with age range of (18-66) years with a solitary functioning kidney that had undergone PNL from September 2015 October 2017 in Sulaymani Teaching Hospital were prospectively analyzed. Serum creatinine was measured preoperatively and 7 days postoperatively. Preoperative, operative and postoperative details were analyzed for each patient with respect to change in eGFR between pre and postoperative period. Multivariate analysis was done to find relations between variable, p-value < 0.05 was considered as significant.

Results

There was a significant increase in the mean postoperative eGFR in (P-value <0.001). Age, gender, BMI, DM, history of ipsilateral renal surgery, grade of hydronephrosis, stone complexity and location have no considerable impact on postoperative renal function impairment (p-value >0.05). Operative time, the number of working tracts and the size of amplatz sheath also have no impact on the deterioration of renal function. Hypertension caused a significant decrease in the postoperative eGFR (p-value 0.01) and blood loss more than average (Hb drop >1.072gm/dl) caused either stable or decrease in the postoperative eGFR (P-value 0.03).

Conclusion

Percutaneous nephrolithotomy is safe in solitary kidney patients and early renal function improvement is anticipated. History of hypertension and bleeding are the two blamed risk factors that cause acute postoperative renal function deterioration.
EPIDEMIOLOGIC AND PATHOLOGIC CHARACTERISTICS OF PATIENTS WITH ESOPHAGEAL CARCINOMA AT KURDISTAN CENTER FOR GASTROENTEROLOGY AND HEPATOLOGY
Authors: Ibrahim Abdullah , Lake Rebaz , Salih Karokh , Mohammed Mohammed
Published: July 2019

Background  Esophageal carcinoma is the sixth in cancer incidence and cancer related deaths. There are marked geographic variations in the incidence of different types and etiology/risk factors for esophageal carcinoma. Better understanding of the etiology/ risk factors may suggest opportunity for its primary prevention.  Objectives  To assess the demographic characteristics, etiology and risk factors of patients with esophageal carcinoma at Kurdistan Center for Gastroenterology and Hepatology. Materials and Methods A cross sectional study extended from March 2014 to December 2015; during this period100 patients with histologically diagnosed as esophageal carcinoma (EC) were included. Details about the demographic characteristics and risk factors for esophageal carcinoma had been reviewed. Results The mean age of the study population was 67±13.27 years. The male constituted 58% and female 42%, (75%) were Squamous cell carcinoma (SCC) and (25%) were Adenocarcinoma (AC). Up to 84% of AC cases were male (P value: 0.002). There was significant association beteewn type of esophageal cancer and tea drinking, temperature of tea and interval between tea being poured and drunken, P- value was 0.011, 0.031 and 0.001 respectively. There was no statistically significant association between types of EC and demographic characteristic, smoking and body mass index. Conclusion SCC was more common than AC; AC was more common in males. Drinking hot tea was associated with EC. Most patients were smoker and had low fruit and vegetable intake, with more dried and preserved foods intake.
USE OF LIPID PROFILE AS MARKER OF SEVERITY IN PRE-ECLAMPSIA
Authors: Mahmood Maryam
Published: July 2019

Background 

Pre-eclampsia is the major cause of maternal morbidity and mortality, preterm birth, perinatal death, and intrauterine growth restriction. The incidence of pre-eclampsia globally varies widely from 5-15 percentages. Studies result’s find correlation of essential hypertension with alteration of serum cholesterol, triglycerides and HDL-C, various studies claim that abnormal lipid synthesis leading to increase of thromboxane level and the decrease of prostaglandin levels.

Objectives 

To assess changes in lipid profile in pre-eclampsia and if these changes can be used as a marker of severity of the condition.

Patients and Methods

Case-control Study at Sulaimani Maternity Teaching Hospital from 01. Feb. 2017 to 01. Aug. 2017, it includes 100 pregnant women divided into three groups. Control group who remained normotensive during study period and case group who subdivided to two group including those cases who developed mild and sever pre-eclampsia during study period.

Results

There was significant rise in the serum TC, TG, LDL and VLDL and decrease in HDL in pre-eclamptic groups compared to normal healthy pregnant women. When we compare patient with sever pre-eclampsia with patient with mild pre-eclampsia we found that women with sever pre-eclampsia has significantly higher level of TG (334.9 ± 97.8vs 250.2 ± 31.5) and VLDL (66.4 ± 19.8vs45.4 ± 12.7 only.

Conclusion

Maternal dyslipidemia early in second trimester may be an indicator for development of future pre-eclampsia.
BUPIVACAINE VERSUS LIDOCAINE LOCAL ANESTHESIA FOR OPEN CARPAL TUNNEL RELEASE: A RANDOMIZED COMPARATIVE STUDY
Authors: Saeed Areewan
Published: July 2019

Background 

Carpal tunnel syndrome is symptomatic compression of the median nerve at the wrist; surgery can be performed under general and local anesthesia. Local anesthesia is associated with shorter operative time and fewer coasts.

Objectives

To compare the use of Bupivacaine and Lidocaine when performing open carpal tunnel surgery.

Patients and Methods

We studied the visual analogue scale, intraoperative blood loss and postoperative intake of analgesics in 85 patients (100 wrists), whom divided randomly to two groups, each receiving one type of local anesthesia. Age range 20-80years, female 84 and one male, 61 patients having moderate and 24 having severe grades.

Results

The mean visual analogue score was significantly less in the first group the first10 hours, 7 days and 14 days postoperatively (p values 0.001, 0.001, 0.02), thereafter the mean difference was not significant (P value 0.06-0.11). Intra operative bleeding was significantly less in the bupivacaine group (66% ≤ 6 ml) when compared to the Lidocaine group, (92% ≥6ml and 59% having loss of 10 ml). The difference in consumption of acetaminophen in the first two weeks was statistically significant. In the first group 39 patients (76.4%) taking <15 grams, while in the second group 36 patients (73.4%) taking >15 grams.

Conclusion

Bupivacaine provides longer postoperative pain relief, less chance of long standing pain and significantly less intraoperative bleeding. The need for postoperative analgesia is significantly less making the procedure relatively safe and less coasty when using bupivacaine.
Телесно-ориентированная психотерапия: специфика, возможности, механизмы воздействия
Authors: Леви Татьяна Самуиловна
Published: July 2019

В статье раскрываются содержательные и этические основы  телесно-ориентированной психотерапии, ее специфика и возможности в работе с различной психологической проблематикой. Расширение телесного осознавания, в процессе которого происходит изменение отношения человека к своему телу от объектного к субъектному рассматривается в качестве основного направления в деятельности телесного психолога.
Модель социокультурного мониторинга городского межэтнического сообщества в реализации национальной политики на муниципальном уровне
Authors: Попков Юрий Владимирович
Published: July 2019

Статья является откликом на обозначенную в новой редакции 2018 г. Стратегии государственной национальной политики Российской Федерации на период до 2025 г. актуализацию роли муниципального управления в ее реализации. Выделяется серия концептуальных вопросов национальной политики, не нашедших отражения в ее доктринальном источнике. Среди них вопрос об объекте национальной политики и ее базовом мониторинге. Отстаивается идея о том, что этносоциальные процессы, а не только межнациональные (межэтнические) отношения и конфликты следует рассматривать в качестве комплексного объекта национальной политики.

Носителем этносоциальных процессов и одновременно элементарной единицей исследования и регулирующего воздействия в рамках национальной политики на муниципальном уровне должно рассматриваться межэтническое сообщество в целом как некоторое комплексное интегрированное образование, которое исторически складывается в результате межэтнических взаимодействий. Обосновывается потребность организации модели социокультурного мониторинга городского межэтнического сообщества как значимого элемента в механизме реализации национальной политики на муниципальном уровне, учитывающей ее не только текущие (тактические), но и стратегические задачи по диагностике и прогнозированию долгосрочных тенденций этносоциального развития. Предлагается система показателей социокультурного мониторинга городского межэтнического сообщества. Его концептуальная схема предусматривает учет комплекса социальных, культурных и личностных компонентов, что не рассматривается в качестве составляющих в существующих мониторинговых исследованиях. Данная модель имеет динамичный характер. С помощью такого мониторинга можно отслеживать динамику и сдвиги на социокультурной карте города, а также осуществлять социокультурное моделирование межэтнического пространства.
Assessment of the equivalence of technical materials of analogous pesticides to original active substances on the basis of “mutagenicity” criterion
Authors: Ilyushina Nataliya A.
Published: July 2019

In the Russian Federation about 600 active ingredients of pesticides are currently registered. A large share among them is occupied by analogous pesticides (generics), which may differ in their properties from the original products due to an increased level or altered composition of impurities. Therefore, to ensure the safe use of analogous pesticides, it is necessary to evaluate their chemical and toxicological equivalence. The analysis of algorithms described in international documents and implemented in practice in some countries for determination of the equivalence of technical materials of analog pesticides is presented. Particular attention is paid to the evaluation of pesticide safety on the basis of the mutagenicity criterion. The applicability of different methods for genotoxic activity determination to confirm the equivalence of active substances of pesticides-analogues to patented products is discussed. A brief review of the results of the researches confirming the need to assess the genotoxicity of all technical materials of analogous pesticides with a view to preventing the entry of hazardous substances into the consumer market is presented.
Diversity of RNA interference pathways in regulation of endogenous and exogenous sequences expression in ciliates Tetrahymena and Paramecium
Authors: Nekrasova Irina V. , Potekhin Alexey A.
Published: July 2019

RNA interference plays a major role in biology of ciliates. Diverse small RNAs regulate many processes in vegetative cells of ciliates Tetrahymena and Paramecium. Different types of endogenous and exogenous nucleotide sequences induce different RNAi pathways resulting in silencing of the homologous sequences in the macronuclear genome. Likely this way ciliates are able to quickly inactivate heterogeneous sequences and to adapt efficiently to the environmental conditions and external stimuli.
Artificial activation of nif gene expression in nodule bacteria Ex Planta
Authors: Baymiev Andrey K. , Gumenko Roman S. , Vladimirova Anastasiya A. , Akimova Ekaterina S. , Vershinina Zilya R. , Baymiev Aleksey K.
Published: July 2019

Background. Rhizobia are the most effective nitrogen-fixing organisms that can fix nitrogen only in symbiosis with leguminous plants. The general transcriptional activator of nitrogen fixation genes in diazotrophic bacteria is NifA. In this work, the possibility of modifying the regulation of nitrogen fixation in the nodule bacteria Mesorhizobium, Ensifer and Rhizobium was studied by introducing an additional copy of the nifA gene into the bacterial genomes during the regulation of induced bacterial promoters.
Materials and methods. A series of expression genetic constructs with NifA genes of nodule bacteria strains under the control of an inducible promoter Pm were created. The resulting constructs were transformed into strains of nodule bacteria. The obtained recombinant strains were investigated for the appearance of their nitrogen-fixing activity in the free-living state.
Results. It was shown that the expression of nifA in recombinant cells of all three genera of bacteria leads to the appearance of insignificant nitrogenase activity. At the same time, the level of nitrogenase activity does not have a correlation with the level of expression of the introduced nifA gene, which, most likely, is a consequence of the multilevel regulation of nitrogen fixation.
Conclusion. The possibility of artificial activation of nitrogenase activity in nodule bacteria in the free-living state by introducing the NifA regulatory protein gene into bacteria was shown.
Articulo Plan de vida organizacional como catalizador en la reinvención del desarrollo competitivo de empresas manufactureras de arcilla
Authors: Jiménez Rodríguez Luis Alfredo , Vargas René , Vera Carlos , Gamboa Ramiro
Published: July 2019

El siguiente esbozo teórico tiene como propósito fundamental, hablar del plan de vida organizacional como catalizador en la reinvención del desarrollo competitivo de empresas manufactureras y se efectuó, fundamentándose en las categorías plan de vida organizacional y reinvención del desarrollo competitivo. A su vez, el proceso investigativo se enfocó en el paradigma post positivista, desarrollándose en la metodología cualitativa y basada en la teoría fundamentada, realizando procesos de codificación y análisis de la información, con la intención de ir creando teoría de forma sistemática. Entre los resultados del trabajo investigativo, se identificaron los elementos de direccionamiento estratégico y describieron los pasos del plan de vida organizacional en las empresas del sector arcilla, detectando tanto elementos positivos como falencias en ambos casos y que trajeron como consecuencia, la propuesta de lineamientos que sugieren intensificar elementos importantes a considerar en la reinvención del desarrollo competitivo de estas organizaciones en base a un plan de vida organizacional bien estructurado considerando el buen desarrollo profesional y personal de cada integrante de las organizaciones del sector
Lack of significant effect of interleukin-18 gene variants on tuberculosis susceptibility in the Polish population
Authors: Wawrocki Sebastian , Kielnierowski Grzegorz , Rudnicka Wieslawa , Druszczynska Magdalena
Published: July 2019

Background: Polymorphisms in genes encoding cytokines are known to determine susceptibility to Mycobacterium tuberculosis (M.tb) infection. In particular, interleukin-18 (IL-18), an inducer of interferon-gamma (IFN-γ), playing an important role in anti-mycobacterial immune responses, may influence the risk of developing active tuberculosis (TB). Aim: A case-control study was performed to investigate whether two promoter polymorphisms of the IL-18 gene at positions -137G/A (rs187238) and -607A/C (rs1946518) affect the serum level of IL-18 and might be associated with genetic susceptibility to tuberculosis (TB) in the Polish population. Methods: Two IL-18 gene promoter SNPs were detected by an allele-specific polymerase chain reaction. Serum IL-18 levels were measured immunoenzymatically using Human Total IL-18 ELISA DuoSet (R&D). Results: A single-gene analysis showed no differences either in allele or genotype frequencies of the studied SNPs between TB patients and healthy controls. No significant differences in the frequencies of any of the haplotypes between TB patients and healthy controls were found. None of the polymorphic variants of IL-18(-137G/A) or IL-18(-607A/C) SNP was associated with IL-18 producing capability. Conclusion: Our results suggest that IL-18(-137G/A) and IL-18(-607A/C) polymorphisms may not be risk factors for susceptibility to TB in the Polish population. Increased serum IL-18 level observed in TB patients has no genetic background, but is a consequence of M.tb infection. Further studies with a higher sample size are required to confirm these findings.
Tucumã extracts decreases PML/RARΑ gene expression in NB4/APL cell line
Authors: Copetti Priscila Marquezan , Oliveira Pablo Sebastian de Britto , Garcia Luis Felipe Machado , Vaucher Rodrigo Almeida , Duarte Marta Medeiros Frescura , Krause Luciana Fontanari , Cruz Ivana Beatrice Mânica da , Ourique Aline Ferreira , Sagrillo Michele Rorato
Published: July 2019

Acute promyelocytic leukemia (APL) is a cancer pharmacologically treated with all-trans retinoic acid (ATRA), although well tolerated by most patients, some develop toxicity to ATRA, Differentiation Syndrome. The Amazon Biome has several fruits and oil plants rich in micronutrients, particularly carotenoids as the fruit tucumã (Astrocaryum aculeatum). This study analyzed the antitumor and cytoprotective activity of tucumã with and without concomitant exposure of ATRA in high concentration mimicking the toxicity of differentiation syndrome, as the potential cytotoxic effect of chemotherapeutic in an APL cell line. The cultured NB4 cells were exposed to ethanolic extracts of tucumã and to synergism with extracts and ATRA. Determination of proliferation, cell viability, caspases 1, 3, 8 and cell differentiation by nested RT-qPCR. The ATRA control had a strong inhibitory effect and toxicity as expected. The extracts also reduced cell proliferation by triggering apoptosis in concentration-dependent and reversing chromosome translocation, especially the lowest tested concentration of tucumã pulp extract. In the synergism, extracts act to maintain the levels of viability and apoptosis equal to the ATRA control but in contrast to drug that causes death and destruction of the genetic material, tucumã demonstrated a reduction of the gene expression indicating a possible protection against the toxicity of high concentrations of ATRA. These results suggest that fruits rich in retinoid molecules may have a cytotoxic effect against APL cells and reduced concentrations of carotenoids may act as cytoprotectors in APL cells treated with high concentrations of ATRA promoting cellular/molecular differentiation.
STUDY OF NEPETAE CATARIAE HERBA FRUITS AS PROMISING MEDICINAL PLANT RAW MATERIAL
Authors: Devyatov A. G. , Lapshin G. S. , Babaeva E. Yu. , Motina E. A. , Zvezdina E. V. , Vandishev V. V.
Published: July 2019

Nepetae catariae herba is used in the Russian Federation as spice. The chemical compounds of herb have been studied. This plant has been introduced into the culture. There are its domestic varieties. The fruits of the plant accumulate up to 25% of fatty oil and contain specific laballenic acid, which has a wide range of antimicrobial and fungicidal actions. The yield of fruit crops is 5–6 c/ha.

The aim is to study some criteria for the standardization of the quality of Nepetae catariae herb as a new medicinal plant raw material.

Materials and methods. The studied fruits are from the biological collection of Federal State Budgetary Institution of All – Russia Research Institute of Medicinal and Aromatic Plants. Binocular magnifier brand MBS-10 and Axioplan 2 imaging microscope by Carl Zeiss were used. The sample preparation was carried out according to the State Pharmacopoeia of the Russian Federation (XIV edition). Anatomical diagnostic features were studied in powder and cross section with staining reagents for the presence of some biologically active substances. Qualitative reactions were carried out with water and alcohol-water extracts from the fruits. The content of the lipid complex according to pharmacopoeia monograph 2.5.0035.15 has been determined.

Results. A description of the external and diagnostic anatomical features is given. The main groups of biologically active substances and the content of the lipid complex in a possible new material – the fruits of Nepeta cataria – have been identified.

Conclusion. The description of the external features of the fruit has been specified. For the first time, crushed fruits have been characterized. It has been established that the morphology of endocarp cells and seed embryo cells are best preserved in a mellow fruit. Physico-optical properties of cellular structures and the ability for basic microchemical reactions are preserved in all zones of pericarp and seeds. Qualitative reactions showed the presence of the following components in the fruits: saponins, flavonoids and a lipid complex. A dispersion composition has been studied. The yield of the lipid complex and its appearance have been determined. Fruits can be used as promising fat-oil raw materials. The results of the study can be used in drafting Pharmacovigilance Reference Document considering a promising type of medicinal plant raw material on the basis of Nepetae catariae herba fruits.
STUDY OF BAICALIN HYDROLYSIS KINETICS IN THE PROCESS OF ITS EXTRACTION FROM SCUTELLARIA BAICALENSIS GEORGI ROOTS
Authors: Boyko N. N. , Pisarev D. I. , Zhilyakova E. T. , Maljutina A. Yu. , Novikov O. O. , Bocharnikova M. A.
Published: July 2019

The aim of this study was to investigate the kinetics of baicalin hydrolysis in the process of its extraction from Scutellaria baicalensis Georgi roots.

Materials and methods. For the studies, Scutellaria baicalensis Georgi roots with a particle range of 0.1–0.5 mm were used. The method of extraction was a simple maceration during a specified period of time, the ratio of plant raw material : extractant was 1:10 w/v at the temperature of 24±1°С. Baicalin and baicalein contents were analyzed by reverse phase high performance liquid chromatography (RP HPLC) at the analytical wavelength of 275 nm. The extractant was a water solution of ethanol 26, 43, 59, 72, 81, 97±1% v/v. The time of the extraction was from 1 to 24 hours.

Results. The experimental points of dependency of baicalin concentration in the extract on the time of extraction for ethanol solutions with a concentration of 43 and 72% v/v are closely approximated by a linear equation in coordinates lnC=f(t). The value of determination coefficient is more than R²˃0,99. Half lifetime for baicalin has been calculated: for ethanol with the concentration of 43% v/v it is 4.3±0.7 hours, and for ethanol with the concentration of 72% v/v it is 42.3±1.8 hours.

Conclusion. Baicalin hydrolysis kinetics in the process of its extraction from Scutellaria baicalensis Georgi roots with 43 and 72% v/v ethanol concentration. has been studied. It has been established that the process of baicalin hydrolysis is well described by the first order kinetic equation. The constants of baicalin hydrolysis during its extraction from Scutelaria baicalensis roots with ethanol having different concentrations have been calculated. Recommendations on technology optimization for baicalin or baicalein extraction from Scutellaria baicalensis Georgi roots have been given.
OPTIMIZATION OF THE METHOD FOR OBTAINING NANOCAPSULES, DEVELOPMENT OF THE METHODS OF DETERMINING THE DEGREE OF CINNARIZINE INCLUSION IN A PROLONGED DOSAGE FORM BASED ON POLY-D, L-LACTID-CO-GLICOLIDE, AND ITS VALIDATION
Authors: Sorokoumova M. V. , Blagorazumnaya N. V. , Kompantsev V. A. , Shcherbakova L. I. , Zyablitseva N. S. , Medvetskaya Yu. G. , Vasina T. M. , Miroshnichenko K. A.
Published: July 2019

Common pathologies of the cardiovascular system are cerebrovascular disorders, for which cinnarizine is prescribed. An innovative, prolonged nanocapsule dosage form based on poly-D, L-lactide-co-glycolide (PLGA) has been developed.

The aim of the research was improvement of the technology and development of the methods for determining the level of cinnarizine inclusion in nanocapsules. The research problem consisted of a great number of drug encapsulation peculiarities, as well as various physicochemical properties of the substances that cannot be taken into account in the existing methods of determination.

Materials and methods. In the study, the following substances were used: cinnarizine, PLGA (50:50), polyvinyl alcohol (PVA). The remaining reagents and solvents fitted into the category of chemically pure. For development of the methods for quantitative determination of cinnarizine and its validation, a spectrophotometric method of analysis was used. Model mixtures used as objects of the study, had been prepared. Validation assessment of the methods was carried out upon such indicators as specificity, linearity, detection limit, repeatability, reproducibility.

Results. Methods for spectrophotometric determination of the degree of cinnarizine inclusion has been developed. It has been established that encapsulation reaches 63.74%. Validation testing methods has been carried out. The results of such tests as specificity, linearity, detection limit, repeatability, reproducibility correspond to the safe range of values regulated by Product specification file. Due to the impossibility of determining the degree of cinnarizine inclusion on the basis of standard methods of preparation, the technology of producing nanocapsules has been adjusted.

Conclusion. The technology has been optimized and new techniques have been developed. Taking into account the characteristics of production and the physicochemical properties of the components, they make a reliable analysis of the degree of cinnarizine inclusion in nanocapsules possible. The relative error of the developed methods of determination does not exceed ± 2.67%. Based on the results of the validation assessment, this methods is valid for all indicators.
MODERN MODEL FORMATION OF DRUG PROVISION OF PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA IN KABARDINO-BALKARIA
Authors: Umirova A. A. , Adzhienko V. L. , Kabakova T. I. , Korzhavykh E. A. , Gatsan V. V.
Published: July 2019

The increase in the incidence of community-acquired pneumonia (СAP) is a major problem of national and regional importance. Its pharmacotherapy is based on the active use of antibacterial drugs. That requires a special attention of both, a doctor and a patient, the search for all new and advanced medicines (drugs).

The aim of the study is to justify and develop a regional model of drug provision of pharmacotherapy in community-acquired pneumonia.

Materials and methods. The use of the resource approach and the methodology of pharmaceutical care (PhC) for the formation of a modern model of drug supply have been tested. Logical, retrospective, sociological, pharmacoeconomic, marketing, statistical and other analytical methods have been used. The materials were official statistics, literature data and the results of the research carried out by the authors themselves.

Results. The state and tendencies of development of organizational, personnel, financial (population) and drug resources as the external factors affecting PhC to patients with CAP in the Kabardino-Balkarian Republic (KBR) have been identified. The following internal factors of PhC have been defined: medical prescriptions, consumer demands and the cost of pharmacotherapy. A model of drug provision for patients with CAP in the region has been formed. It is aimed at increasing the effectiveness of treatment, taking into account the stage of treatment and the price factor.

Conclusion. Under the conditions of a particular region, the use of the resource approach and the PhC methodology allows to more accurately identify the problems and risks of both drug provision and pharmacotherapy of the patients’ population under study, and form a model adequate to reality, develop recommendations for all participants of PhC – a doctor, a patient and a pharmaceutist (a pharmacist).
Diretrizes para o planejamento de uma demolição seletiva em edifícios
Authors: Moreira Martins Andreia Sofia , Reis Daniel Costa , Fabricio Márcio Minto
Published: July 2019

O objetivo do presente artigo é desenvolver um conjunto de diretrizes que permitam aprimorar o planejamento das atividades de demolição e promover práticas mais sustentáveis no canteiro de obras de demolição. A pesquisa empírica foi realizada através de três estudos de caso, desenvolvendo um diagnóstico do funcionamento das atividades das empresas que praticam a demolição seletiva de pequenas edificações, através de entrevistas, acompanhamento das demolições e da revenda dos materiais. Assim sendo, foi possível verificar a existência de mercados para os materiais e componentes reaproveitados que promovem o desenvolvimento local.
Lógicas das mídias da sociedade civil organizada (SCO) quando trabalham o tema ambiental na ótica informativa-jornalística
Authors: Mazzarino Jane Marcia
Published: July 2019

Estão emergindo formas alternativas nas mídias das organizações da sociedade civil organizada (SCO) quando trabalham na ótica informativo-jornalística ou as práticas remetem às lógicas tradicionalizadas pelo campo jornalístico? O objetivo deste artigo é refletir sobre as lógicas das mídias da sociedade civil organizada (SCO) quando abordam o tema ambiental na ótica informativo-jornalística. Abordam-se elementos da interface entre estudos de comunicação midiatizada e SCO utilizando-se a revisão bibliográfica.
A educação superior no contexto da cooperação acadêmica internacional
Authors: Sugamosto Westphal Angela Mara , Gisi Maria Lourdes
Published: July 2019

Este trabalho tem como objetivo analisar a internacionalização da educação superior do Brasil como uma das ferramentas essenciais para o desenvolvimento dos países, ao promover a diminuição das fronteiras culturais, tecnológicas, econômicas e sociais. Trata-se de pesquisa com abordagem qualitativa, realizada mediante análise documental. Discute os resultados obtidos no contexto do processo da Cooperação Acadêmica Internacional em relação à área acadêmica e à pesquisa.
The pesticides law under the optics of rural producers
Authors: Marques Mauricio Dias , Braga Junior Sergio Silva , Forti Juliane Cristina
Published: July 2019

The aim of the current study is to understand the perceptions of rural producers about the procedure for reverse logistics of empty pesticide packages proposed by Brazilian legislation. The research was conducted in Interior of the State of São Paulo for application to 48 small and medium-sized rural producers. As a result, it was found that producers generally do not meet the legal requirements and that one of the possible causes may be the lack of inspection by the Public Authorities
Análise de preços hedônicos no mercado imobiliário residencial de Conselheiro Lafaiete, MG
Authors: Lana Pinto Victor Henrique , Soares Fernandes Rosangela Aparecida
Published: July 2019

O presente artigo consiste na análise dos atributos relevantes na formação dos preços de imóveis residenciais para venda em Conselheiro Lafaiete, MG, em 2016. Estimou-se um modelo hedônico a partir de uma regressão linear múltipla, que permitiu associar o preço dos imóveis às características dos bens imobiliários e de seu entorno. Os resultados sugerem que as variáveis foram relevantes para explicar a variabilidade nos preços dos imóveis, e refletiram a realidade do mercado imobiliário de Conselheiro Lafaiete.
Smoking cessation interventions in substance use treatment facilities: clinical implications and recommendations for implementation
Authors: González-Roz Alba , Ruano Lucía , Aonso-Diego Gema , García-Pérez Ángel , Weidberg Sara , Secades-Villa Roberto
Published: July 2019

There exists an increasing recognition that smoking cessation treatments should be provided alongside substance abuse treatments. However, very scarce evidence of this practice has been reported in Spain. This study sought to provide data on the provision of smoking cessation treatments within substance use treatment facilities in Asturias, Spain. A total of 15 treatment facilities were contacted initially. An ad hoc survey was provided to the principal coordinator of each substance use treatment facility to collect data on the provision of smoking cessation treatments, centers’ restrictions on tobacco use, and barriers to effectively implementing smoking cessation treatments. Of the surveyed centers, only 3 systematically offered smoking cessation treatments. A total of 10 out of 15 centers (66.66%) self-reported any tobacco control measure: banning cigarette exchange (4/10; 40%), limiting time for rolling cigarettes (4/10; 40%), using cigarettes as a prize/punishment (2/10; 20%), and cigarette collection at night (1/10, 10%). Barriers to effectively implementing smoking cessation treatments have been identified at different levels (staff, patient, and organizational). Concerns that smoking abstinence would compromise substance use outcomes were detected as the main barrier to effectively implementing smoking cessation treatments within centers. Several clinical implications are discussed.
On the Determining Role of Texture in Causing Delamination During Impact Fracture of Ti and Nb-Ti Microalloyed Steel
Authors: Sun Mingyu , Wang Xuemin , Misra R.D.K.
Published: July 2019

700 MPa grade Ti and Nb-Ti microalloyed steels produced by thermo-mechanical control rolled processes (TMCP) were studied to elucidate texture that contributes to delamination and consequent impact toughness. The microstructure of Ti and Nb-Ti steels consisted of ferrite and bainite. Compared with Ti steel, Nb-Ti steel was characterized by a microstructure with finer ferrite and more bainite. The results from tensile and impact tests indicated that there is insignificant change in tensile properties, but toughness was greater in Nb-Ti steel compared with Ti steel. More severe delamination in Nb-Ti steel is attributed to stronger α-fiber (RD ||<110>) texture than Ti steel, especially {100}<110>, {113}<110> and {112}<110> texture. Typical cleavage river patterns were not observed on delaminated fracture surface, instead the cleavage fracture surface indicated some dimples. Interestingly, the impact energy of samples with delamination was greater than samples without delamination in the ductile–brittle transition region. The study suggests that delamination in the ductile–brittle transition zone may also be representative of high toughness.
Comparative Mitochondrial Genome Analysis of the Tobacco Endophytic Fungi Leptosphaerulina Chartarum and Curvularia Trifolii and the Phylogenetic Implications
Authors: Yuan Xiao-Long , Cao Min , Shen Guo-Ming , Zhang Huai-Bao , Du Yong-Mei , Zhang Zhong-Feng , Li Qian , Gao Jia-Ming , Xue Lin , Zhang Peng
Published: July 2019

In tobacco plants, symbiont endophytic fungi are widely distributed in all tissues where they play important roles. It is therefore important to determine the species distribution and characteristics of endophytic fungi in tobacco. Here, two parasitic fungi Leptosphaerulina chartarum and Curvularia trifolii were isolated and identified from normal tobacco tissue. We sequenced the mitogenomes of these two species and analysed their features, gene content, and evolutionary histories. The L. chartarum and C. trifolii mitochondrial genomes were 68,926 bp and 59,100 bp long circular molecules with average GC contents of 28.60% and 29.31%, respectively. The L. chartarum mitogenome contained 36 protein coding genes, 26 tRNA genes, and 2 rRNA genes (rrnL and rrnS), which were located on both strands. The C. trifolii mitogenome contained 26 protein coding genes, 29 tRNA genes, and 2 rRNA genes (rrnL and rrnS). The L. chartarum 26 tRNAs ranged from 70 bp to 84 bp in length, whereas the 29 tRNAs in C. trifolii ranged from 71 bp to 85 bp. L. chartarum and C. trifolii mtDNAs had an identical mitochondrial gene order and orientation and were phylogenetically identified as sisters. These data therefore provide an understanding of the gene content and evolutionary history of species within Pleosporales.
Revelation of Children and Adult’s Food Allergen in Malaysia
Authors: Din Norrina , Rashid Basri , Ramli Kamal Izzuwan , Mansor Nur Aliah , Abdullah Dahlan
Published: July 2019

Food allergy has been recognised by the World Health Organisation as a chronic disease that could lead to fatality. The symptoms can mediate from mild to severe consequences. Some cases have reported that food allergy sufferers are bullied and are discriminated at workplace, thus increasing their stress level, apart from facing difficulty in consuming certain food due to allergy. This has an adverse effect on the quality of life amongst food allergy sufferers. Medical bills are increased when food allergy sufferers become unknowingly exposed to food allergen. Hence, this study investigated food allergens among food allergy sufferers in order to make their lives better. A total of 250 respondents participated in an online survey. Surprisingly, apart from chicken, soybean and other food allergens that have been listed under the Big Eight Allergens, the respondents mentioned some fruits that could trigger allergic reactions, such as rambutans and watermelons. Food allergy sufferers can be allergic to seafood and seafood products as well, such as shrimp paste or locally known as belacan, which refers to fermented shrimp paste cured under the sun. It is a common food ingredient used among Malaysians. The study findings offer practical insights, such as avoidance of food allergens amidst food allergy sufferers and help the government to carefully manage for menu planning. The knowledge contribution of this study reveals several specific food and fruits, as aforementioned, which appear to be common and nutritious food, yet harmful to food allergy sufferers.
Quantemol Electron Collisions (QEC): An Enhanced Expert System for Performing Electron Molecule Collision Calculations Using the R-matrix Method
Authors: Cooper Bridgette , Tudorovskaya Maria , Mohr Sebastian , O'Hare Aran , Hanicinec Martin , Dzarasova Anna , Gorfinkiel Jimena , Benda Jakub , Masin Zdenek , Al-Refaie Ahmed , Knowles Peter , Tennyson Jonathan
Published: July 2019

Collisions of low energy electrons with molecules are important for understanding many aspects of the environment and technologies. Understanding the processes that occur in these types of collisions can give insights into plasma etching processes, edge effects in fusion plasmas, radiation damage to biological tissues and more. A radical update of the previous expert system for computing observables relevant to these processes, Quantemol-N, is presented. The new Quantemol Electron Collision (QEC) expert system simplifyies the user experience, improving reliability and implements new features. The QEC GUI interfaces the Molpro quantum chemistry package for molecular target setups and to the sophisticated UKRmol+ codes to generate accurate and reliable cross-sections. These include elastic cross-sections, super elastic cross-sections between excited states, electron impact dissociation, scattering reaction rates, dissociative electron attachment, differential cross-sections, momentum transfer cross-sections, ionization cross sections and high energy electron scattering cross-sections. With this new interface we will be implementing dissociative recombination estimations, vibrational excitations for neutrals and ions, and effective core potentials in the near future.