bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation on Braking Stability of Autonomous Vehicles Running along Curved Sections Based on Asphalt Pavement Adhesion Properties
Authors: Zheng Binshuang , Huang Xiaoming , Tang Junyao , Chen Jiaying , Zhao Runmin , Hong Zhengqiang , Tang Tao , Han Meiling
Published: May 2022

As the main objective influencing factor on the brake safety of autonomous vehicles, pavement texture information is directly related to road surface antiskid performance. However, in the brake system of autonomous vehicles, the influence of road surface adhesion characteristics on braking stability is seldomly considered. To study the braking stability of autonomous vehicles on curved sections under different road conditions, the advanced close-range photogrammetry system was utilized to extract the road surface texture information. Thereafter, the power spectral density (PSD) of the road surface was calculated by MATLAB to obtain the pavement adhesion coefficient curves based on the Persson friction theory model under different road conditions. Considering the pavement adhesion characteristics, the braking model of autonomous vehicles was built in Simulink, and then, the braking performance on curved sections was analyzed with CarSim/Simulink cosimulation. The results indicate that, according to the adhesion coefficient of different asphalt pavement types under different road conditions, the ranking order is open-grade friction course (OGFC) > stone matrix asphalt (SMA) > dense-graded asphalt concrete (AC). In addition, both the maximum lateral offset distances and the maximum lateral forces of the tires decrease as the curve radius gradually increases under different road conditions. It can also be found that there is a relatively uniform vertical forces distribution of the tire when the curve radius is no less than 100 m, and the limit speed of the vehicle varies parabolically with increasing in curve radius. Compared with dry road, the reduction of vehicle braking deceleration is more significant and the yaw rate is greater on wet road. Last but not least, the braking comfort with a radius of 200 m is the best according to the comfort index (CI) in International Standard ISO, in which the comfort level can be sorted into six levels.
Understanding the Dynamics of Knowledge Building Process in Online Knowledge‐Sharing Platform: A Structural Analysis of Zhihu Tag Network
Authors: Li Yongning , Zhang Lun , Wu Ye
Published: May 2022

Through structural analysis of 8‐year tag networks from online knowledge‐sharing platforms, this study finds that, with the scale of tag networks growing quickly, the growth trend of number edges indicates that tag network follows densification law. The clustering coefficient and the average shortest path of the network show that the rapid growth of network size does not bring about the compartmentalization of the knowledge network, and the degree distribution of tag networks shows a truncated power‐law distribution. According to the structural characteristics of the tag network, this study proposes a tag network model based on the BA model. Based on the preference attachment, the triadic closure mechanism is employed to construct the edges between the old nodes, which revises the limitation that the BA model only connects edges between old and new nodes. The results show that the simulation model matches the actual tag network structure well. The generation mechanism of the tag network model provides a reference for understanding the knowledge construction process of the online knowledge‐sharing platform to a certain extent.
Efficiency Analysis and Utilization of College Sports Equipment Based on Intelligent Computing
Authors: Li Chunping , Wang Jie , Yu Qingding
Published: May 2022

Under the background of the new curriculum standard, promote the all-round development of moral education, intellectual education, physical education, aesthetic education, and labor education. Children’s health exercise also makes physical education one of the subjects that schools and parents attach importance to. Different from the teaching methods of other disciplines, physical education is carried out outdoors and has high requirements for equipment and facilities, which is not only related to the effective implementation of physical education but also related to students’ enthusiasm for outdoor physical exercise. It is actually a powerful theoretical support for physical education. With the frequent loss, damage, and lack of sports equipment in colleges and universities, people do not think: how can we manage the equipment efficiently and orderly and keep its integrity? It can be seen that the effective use of school sports equipment and facilities in the new period should grasp the research core, clarify the research direction and goal, and provide strong support for the continuous innovation of school sports education. The management of sports equipment is an important part of the daily work of schools. All schools have formulated management systems and use norms, but from the long-term practice, it is obvious that the implementation of the system and use norms is not ideal, and various management systems and norms become a mere formality. Even physical education teachers do not strictly follow this requirement, resulting in the management process of sports equipment and facilities in trouble. It can be seen that the management of sports equipment is not strictly controlled, and it is difficult to implement it, which limits the application value and effectiveness of sports equipment, and students are prone to safety problems in class. Therefore, the school should employ full-time personnel to manage sports equipment, which also improves the attention of the personnel to equipment management. For equipment damage, many students use equipment wrongly and damage equipment, so reasonable use of equipment and facilities can prolong the service life of equipment and facilities. However, physical education teachers usually do not demonstrate the use of equipment scientifically in the teaching process and lack guidance to students, which leads to many students not paying enough attention to the use of equipment, such as kicking basketball, sitting on a stool with basketball, and inflating football; these are the reasons that lead to the damage of equipment. We can through the intelligent optimization of the management mode of sports equipment for a qualified management delay the service life of equipment.
Thoracic Duct Embolization for Postoperative Lymphatic Fistula
Authors: Erdemir Ayhan , Dökdök Murat , Raşa Kemal
Published: May 2022

Lymphatic fistula as a rare entity particularly emerges after head and neck cancer surgery. It may lead to delayed wound healing, electrolyte loss, malnutrition, dehydration, and immune suppression. Therefore, rapid diagnosis and treatment are of the utmost importance. We aimed to present a lymphatic fistula case who was treated successfully by lymphangiography with percutaneous embolization of the thoracic duct. We believe that minimally invasive techniques could be an alternative to the conservative approach as the first-line choice.
Sugiol Suppresses the Proliferation of Human U87 Glioma Cells via Induction of Apoptosis and Cell Cycle Arrest
Authors: Alharthy Saif A. , Tabrez Shams , Mirza Ahmed A. , Zughaibi Torki A. , Firoz Chelapram K. , Dutta Mycal
Published: May 2022

The diterpenoid, sugiol, has been reported to exert anticancer effects against a number of human cancers. However, the anticancer effects of sugiol have not been evaluated against the human glioma cells. The present study was designed to examine the effects of sugiol on the proliferation of human U87 glioma cells. The results showed that sugiol significantly (

P
<
0.05

) suppressed the viability of the U87 cells in a concentration dependent manner and exhibited an IC50 value of 15 μM. On the other hand, the growth inhibitory effects of sugiol were minimal on the normal human astrocytes. Acridine orange and ethidium bromide staining (AO/EB) staining revealed that sugiol induces apoptosis which was further confirmed by Western blot analysis, wherein upregulation of Bax and downregulation of Bcl-2 were observed in U87 cells. Flow cytometry showed that sugiol causes cell cycle arrest at the G0/G1 stage. The relative percentage of G1 phase was found to be increased from 26.58% at 0 μM to 70.96% at 30 μM sugiol. Taken together, the results suggest sugiol inhibits the growth of glioma cells and may prove to be a lead molecule in the management of human glioma.
Analysis of the Underlying Mechanism of the Jiu Wei Zhen Xin Formula for Treating Generalized Anxiety Disorder Based on Network Pharmacology of Traditional Chinese Medicine
Authors: Shao Heng , Gan Quan , Chen Zhuangfei , Zhu Shasha , Zhu Yanqing
Published: May 2022

Currently, there are many effective pharmacological treatments for generalized anxiety disorder (GAD), formulated herbal granule is also an alternative way. Our research intends to construct a pharmacological network on genetic targets and pathways between Jiu Wei Zhen Xin Formula (JWZXF) and GAD. Through the TCMSP database, we collected the active ingredients of JWZXF and potential targets of the active ingredients. The GAD-related proteins collected from GeneCards database and DisGeNET database were combined. Component-target protein networks were constructed and visualized using Cytoscape 3.8.2 software to comprehensively clarify the relationships between ingredients, components, and targets. The intersection targets were imported into the STRING database, and the protein-protein interaction (PPI) network was constructed. We constructed and analyzed the visualized “drug-target-disease” network. Gene Ontology (GO) enrichment together with Kyoto encyclopedia of genes and genomes (KEGG) enrichment analysis were conducted on the common target through R language. Forty-one effective components and 106 potential targets of JWZXF were found. There were top ten hub genes and multiple important signaling pathways involved in the treatment of GAD with the JWZXF. This study expounded the pharmacological actions and molecular mechanisms of the JWZXF in treating GAD from a holistic perspective. The potential pharmacological effects of the JWZXF are closely related to regulation because not only does it comprehensively analyze the possible mechanism of JWZXF treatment of GAD but it can also facilitate further in-depth research and provide a theoretical basis for the clinical expansion of its application.
Modeling Injury Severity for Nighttime and Daytime Crashes by Using Random Parameter Logit Models Accounting for Heterogeneity in Means and Variances
Authors: Wang Chenzhu , Zhang Ping , Chen Fei , Cheng Jianchuan
Published: May 2022

Understanding the factors contributing to crash severity, along with their influence degrees across different times of day, can assist in better highway design and in developing effective countermeasures for ameliorating highway safety (especially during nighttime). This study examines the influences of risk factors on crash severity, based on comparisons of nighttime and daytime crashes. By using a random parameter approach to account for unobserved heterogeneity, multivariate logit (RPML) models are proposed to analyze the crash severity based on the explanatory factors in terms of the crash, traffic, speed, road geometry, and sight characteristics. The goodness-of-fit and predictive measures highlight the better performance of the proposed models relative to standard models, as the proposed models reduce the unobserved heterogeneity and yield higher precision. In addition, the elasticity effects of the factors are calculated to investigate and compare their impact degrees in daytime and nighttime crashes. The findings could potentially be utilized to guide highway design and policies and to develop specific safety countermeasures.
The Effect of Mandibular Angulation on Preoperative Assessment of Dental Implant Insertion at Premolar Region: CBCT Study
Authors: Mahmoudinezhad Sadaf Sadat , AryanKia Azarnoosh , Shooshtari Sanaz Sharifi , Moradi Kooshan
Published: May 2022

Backgrounds. This study investigated the effect of mandibular angulation on the perioperative evaluation of the implant placement at the premolar region on panoramic reconstructed images using cone beam computed tomography (CBCT). Methods. A total of six dried anonymous human mandibles was included. Two implants were inserted in the left and right first premolar region. CBCT scans were obtained from each mandible at the standard position, +20° extension, and ‐20° flexion. The distance of the implant from the anterior loop of the inferior alveolar nerve and mental foramen was measured. Mean absolute error (MAE) of the distance of the implant from both anatomical landmarks was measured. The Wilcoxon matched‐pair signed‐rank test was used for the comparison of the measurements. All data were analyzed with the Stata program (version 15.1). Results. No statistically significant differences were found between the distance of the implant from the mental foramen and the anterior loop of the inferior alveolar nerve up to 20° extension and flexion at both sides of the mandible. (All p > 0.1) However, a variable range of MAE (SD) in the distance of the implant from different anatomical landmarks was found (0.9 ± 0.7 to 3.3 ± 2.1). Conclusions. We found no statistical difference in measurements of the distance of the implant from two anatomical landmarks at different head positions up to 20° extension and flexion. However, clinically, variable range in the distance of the implant from anatomical landmarks should be considered. Our findings could alert dentists of the possibility of error up to 20° extension and flexion on the perioperative evaluation of dental implant placement.
[Retracted] A Case‐Control Study of Continuous Veno‐Venous Hemofiltration Combined with Xuebijing Injection in the Treatment of Severe Sepsis
Authors: Liu Yan , Wang Bing , Zhang Qian , Zhao Yuliang , Wang Xudong
Published: May 2022

A case‐control study was conducted to evaluate the efficacy of continuous veno‐venous hemofiltration (CVVH) combined with Xuebijing in the treatment of severe sepsis. In order to verify this claim, this study included 100 patients with severe sepsis treated in our hospital from February 2019 to April 2021. The patients were randomly divided into control group and study group. The control group was treated with CVVH, and the study group was treated with CVVH combined with Xuebijing. The curative effect and mortality, NT‐proBNP, PCT, Ca∼_(2+), white blood cell count, neutrophil ratio, blood gas analysis, and APACHE‐II score were compared between the two groups. The total effective rate of the study group was better than that of the control group (P < 0.05). The fatality rate in the study group was lower than that in the control group (P < 0.05). The levels of NT‐proBNP and PCT in the study group were lower than those in the control group, while the level of serum calcium in the study group was higher than that in the control group. After treatment, the white blood cell count (WBC) and neutrophil count in the study group were (13.76 ± 1.28) × 109 shock L and (73.48 ± 1.23)%, respectively, which were significantly lower than those in the control group (17.45 ± 1.36) × 109 shock L and (77.82 ± 1.44)% (P < 0.05). After treatment, the levels of APTT, PT, and DD in the study group were lower than those in the control group. The level of FIB in the study group was significantly higher than that in the control group after treatment. After treatment, the PaO2 and PaO2/FiO2 of the study group were higher than those of the control group, and the APACHE‐II score of the study group was lower than that of the control group. CVVH combined with Xuebijing is of positive significance in the treatment of severe sepsis and is worth popularizing.
Th22 Cells/IL-22 Serves as a Protumor Regulator to Drive Poor Prognosis through the JAK-STAT3/MAPK/AKT Signaling Pathway in Non-Small-Cell Lung Cancer
Authors: Yao Yinan , Yang Guangdie , Lu Guohua , Ye Jiani , Cui Luyun , Zeng Zhu , Chen Junjun , Zhou Jianying
Published: May 2022

The interaction of immune cells and cytokines in the tumor microenvironment affects the development and prognosis of tumors with an unclear potential regulatory mechanism. Recent studies have elucidated the protumor role of Th22 cells and its lineage-specific cytokine IL-22 in different human cancers. The present study is aimed at investigating the biological effect of Th22 cells/IL-22 and its molecular mechanism in the pathogenesis process of non-small-cell lung cancer (NSCLC). It was initially found that Th22 cells were enriched in the peripheral blood of NSCLC patients. The level of Th22 cells in peripheral blood mononuclear cells (PBMCs) was positively correlated with the TNM stage, lymph node metastasis, and clinical tumor biomarkers. Furthermore, IL-22 not only antagonized the apoptosis inducing and cell cycle arresting effect by chemotherapy and molecular targeted drugs on NSCLC cell lines but also promoted tumor cell proliferation and tumor tissue growth. Moreover, IL-22 activated the JAK-STAT3/MAPK/AKT signaling pathway, both in vitro and in vivo. Conclusively, the present results confirm that Th22 cells/IL-22 may serve as a negative immune regulator in lung cancer.
COL11A1 is Downregulated by miR-339-5p and Promotes Colon Carcinoma Progression
Authors: Liu Weizhi , Meng Ke
Published: May 2022

The roles of COL11A1 in cancer have been increasingly considered, but the understandings of the effects of COL11A1 on colon carcinoma progress are much limited yet. qRT-PCR and Western blot were utilized to evaluate COL11A1 expression at mRNA and protein levels, respectively, in colon carcinoma cell lines. Afterward, the tumorigenesis biological effects of COL11A1 were examined by CCK-8, colony formation, Transwell, and wound healing methods. Moreover, upstream miRNAs containing the binding sites with COL11A1 were predicted by the bioinformatics methods. The interplay between COL11A1 and miR-339-5p was identified by a dual-luciferase assay. COL11A1 expression was prominently upregulated in colon carcinoma cell lines relative to that in normal human colon mucosal epithelial cell lines, and it was related to tumor stages. The outcomes of in-vitro experiments suggested that interfering with COL11A1 remarkably repressed the malignant behaviors of SW480 and SW620 cells. MiR-339-5p was markedly lowly expressed in colon carcinoma cell lines. Furthermore, miR-339-5p directly targeted and negatively regulated COL11A1 expression. COL11A1 upregulation promoted colon carcinoma cell functions, while overexpressing miR-339-5p evidently attenuated the promotion. These results proved the modulation of the miR-339-5p/COL11A1 axis in colon carcinoma cells, and miR-339-5p repressed colon carcinoma progression via COL11A1 downregulation. These results offer new underlying targets for the accurate therapy of colon carcinoma patients.
Constructing Multiple‐Objective Portfolio Selection for Green Innovation and Dominating Green Innovation Indexes
Authors: Li Meng , Liao Kezhi , Qi Yue , Liu Tongyang
Published: May 2022

Green innovation investments have rapidly grown since 2000. Green innovation indexes play important roles and are typically constructed by screening and indexing. However, Nobel Laureate Markowitz emphasizes portfolio selection instead of security selection and accentuates that “A good portfolio is more than a long list of good stocks.” Moreover, the screening‐indexing strategies ignore that investors can take green innovation as an additional objective and thus gain additional utility. We consequently construct 3‐objective portfolio selection for green innovation in addition to variance and expected return. An efficient frontier of portfolio selection then extends to an efficient surface which is a panorama of the optimal variance, expected return, and expected green innovation. Investors thus fully envisage the trade‐offs and enjoy the freedom of choosing preferred portfolios on the surface. In contrast, the screening‐indexing strategies inflexibly leave investors with only one point (i.e., the green innovation index). As the originality, we prove in a theorem that there typically exists a curve on the efficient surface so all portfolios on the curve dominate the green innovation index. We test the dominance by component stocks of China Securities Index 300 and obtain affirmative results out of sample. The results still hold in robustness tests. At last, we classify green innovation into categories, further model the categories by general k‐objective portfolio selection, and still illustrate the dominance. Consequently, investors can consider and control each category.
Comprehensive Modeling in Predicting Liquid Density of the Refrigerant Systems Using Least-Squares Support Vector Machine Approach
Authors: Cai Jinya , Zhang Haiping , Yu Xinping , Seraj Amir
Published: May 2022

A robust machine learning algorithm known as the least-squares support vector machine (LSSVM) model was used to predict the liquid densities of 48 different refrigerant systems. Hence, a massive dataset was gathered using the reports published previously. The proposed model was evaluated via various analyses. Based on the statistical analysis results, the actual values predicted by this model have high accuracy, and the calculated values of RMSE, MRE, STD, and R2 were 0.0116, 0.158, 0.1070, and 0.999, respectively. Moreover, sensitivity analysis was done on the efficient input parameters, and it was found that CF2H2 has the most positive effect on the output parameter (with a relevancy factor of +50.19). Furthermore, for checking the real data accuracy, the technique of leverage was considered, the results of which revealed that most of the considered data are reliable. The power and accuracy of this simple model in predicting liquid densities of different refrigerant systems are high; therefore, it is an appropriate alternative for laboratory data.
Clinical Evaluation of Titanium‐Alloy Bands for Sternal Closure after Median Sternotomy: Single‐Center Experience
Authors: Qiu Feng , Wang Su , Jin Xianglan , Wu Xiaoyun , Zhou Jian
Published: May 2022

Background. Median sternotomy is the most applied approach in open‐heart surgery, while potential complications such as postoperative bleeding, sternal dehiscence, and deep sternal wound infection (DWSI) still remain a challenge to cardiac surgeons. Several new sternum‐closure products instead of stainless wire have been brought into clinical application. The objective of this retrospective study is to evaluate the novel sternum‐fixing product in terms of clinical outcomes. Methods. 689 consecutive cases undergoing cardiac surgery through median sternotomy between February 2015 and December 2018 in our center were enrolled in this study. All the cases were divided into two groups according to different sternum fixation methods: wire cerclage group and rigid fixator group. The demographic as well as clinical data including the mediastinal drainage of first, second, and third post‐op 24 hours, the total mediastinal drainage of post‐op 72 hours, ICU duration, length of hospital stay, and post‐op mortality in 30 days were collected and compared between the two groups. Results. 278 cases were enrolled in the wire cerclage group and 411 cases in the rigid fixator group. There is no significant difference in the demographic data between the two groups, while the mediastinal drainage in the first and third 24 hours after surgery and the total mediastinal drainage in postoperative 72 hours of the rigid fixator group were significantly less than those of the wire cerclage group (P < 0.05). No significant difference was found in other clinical outcomes between the groups including ICU duration, LOS in hospital, and 30‐day mortality. 14 cases (5.0%) in the wire cerclage group and 11 cases (2.7%) in the rigid fixator group had sternotomy‐related complications including severe postoperative bleeding, sternal dehiscence, and DSWI. Conclusion. Compared with the conventional wire cerclage, the new rigid fixator is superior in median sternotomy closure in terms of postoperative mediastinal bleeding as well as incidence of sternotomy‐related complications.
An Experimental Analysis of Hierarchical Rail Traffic and Train Control in a Stochastic Environment
Authors: Wang Pengling , Jeiziner Annik , Luan Xiaojie , De Martinis Valerio , Corman Francesco
Published: May 2022

The hierarchical connection of Rail Traffic Management System (TMS) and Automatic Train Operation (ATO) for mainline railways has been proposed for a while; however, few have investigated this hierarchical connection with the real field. This paper studies in detail the benefits and limitations of an integrated framework of TMS and ATO in stochastic and dynamic conditions in terms of punctuality, energy efficiency, and conflict-resolving. A simulation is built by interfacing a rescheduling tool and a stand-alone ATO tool with the realistic traffic simulation environment OpenTrack. The investigation refers to different disturbed traffic scenarios obtained by sampling train entrance delays and dwell times within a typical Monte Carlo scheme. Results obtained for the Dutch railway corridor Utrecht–Den Bosch prove the value of the approach. In case of no disruptions, the implementation of ATO systems is beneficial for maintaining timetables and saving energy costs. In case of delay disruptions, the TMS rescheduling has its full effect only if trains are able to follow TMS rescheduled timetables, while the energy-saving by using ATO can only be achieved with conflict-free schedules. A bidirectional communication between ATO and TMS is therefore beneficial for conflict-resolving and energy-saving.
Effects of Different Anesthetics on Perioperative Organ Protection and Postoperative Cognitive Function in Patients Undergoing Cardiac Valve Replacement with Cardiopulmonary Bypass
Authors: Mei Shenglan , Jia Yifan , Zhou Jinjian , Zhan Ling , Liu Jin , Ming Hao , Liu Huagang
Published: May 2022

In this paper, we have carried out an experimental study to investigate the effects of different anesthetics on perioperative organ protection and postoperative cognitive function in patients undergoing cardiac valve replacement with cardiopulmonary bypass. To realize this idea, a total of 90 patients with single valve replacement under general anesthesia and hypothermic cardiopulmonary bypass from January 2020 to October 2021 were enrolled. These patients were assigned into three groups, with 30 cases in each group by the digital table method. Group A was anesthetized with sufentanil combined with dexmedetomidine. Group B was anesthetized with sufentanil combined with etomidate. Group C was anesthetized with sufentanil combined with propofol. Perioperative organ protection and postoperative cognitive function of the three groups were compared. At T0 time point, there was no significant difference in blood WBC, blood N, and CRP among groups A, B, and C (

P

 > 0.05); At T4 and T5 time points, the indexes of blood WBC, blood N, and CRP in groups A, B, and C were higher compared to the T0 time point. At T4 and T5 time points, the indexes of blood WBC, blood N, and CRP in group A were significantly lower compared to group B and group C. Before treatment, there was no significant difference in ALT and AST among groups A, B, and C (

P

 > 0.05). After treatment, the indexes of ALT and AST in group A were significantly lower compared to group B and group C at T4 and T5 time points (

P

 < 0.05). Before treatment, there was no significant difference in urea and creatinine among groups A, B, and C (

P

 > 0.05). After treatment, the urea and creatinine indexes of group A were significantly lower compared to group B and group C at T4 and T5 time points (

P

 < 0.05). Before treatment, there was no significant difference in CK-MB and CTnl among groups A, B, and C (

P

 > 0.05); After treatment, the indexes of CK-MB and CTnl in group A were significantly lower compared to group B and group C at T4 and T5 time points (

P

 < 0.05). Before treatment, there was no significant difference in MOCA scores among groups A, B, and C (

P

 > 0.05). After treatment, the MOCA scores of group A were significantly higher compared to group B and group C at T5 and T6 time points (

P

 < 0.05). Sufentanil combined with dexmedetomidine for heart valve replacement under cardiopulmonary bypass can reduce the dosage of anesthetics during the operation and have a certain perioperative protective effect on important organs such as the heart, lung, liver, and kidney, which may be related to reducing intraoperative hemodynamic fluctuations and inhibiting inflammatory stress response.
Systemic Lupus Erythematosus and Hereditary Coproporphyria: Two Different Entities Diagnosed by WES in the Same Patient
Authors: Liu Anlei , Zhou Lingli , Zhu Huadong , Li Yi , Yang Jing
Published: May 2022

Background. Hereditary coproporphyria (HCP) is a rare autosomal dominant disorder caused by a partial deficiency of coproporphyrinogen III oxidase (CPOX), and systemic lupus erythematosus (SLE) is an autoimmune disease with a strong genetic predisposition. SLC7A7 (solute carrier family 7 member 7) may be associated with monogenic lupus disease; however, only 2 cases of concomitant HCP and SLE have been reported. Methods. We report a 30‐year‐old woman with a six‐year history of SLE presenting with abdominal pain, vomiting, dysuria, tachycardia, and hyponatremia. Whole exome sequencing (WES) and Sanger sequencing were carried out for the proband and members of her pedigree to detect the genetic background. The Gene Expression Omnibus (GEO) database was used to search the related gene expression profiles. Differentially expressed genes (DEGs) were identified using GEO2R. Result. A novel heterozygous splicing mutation of CPOX (NM_000097): c.700+2 T > C (intron 2) was detected by WES in the proband, and it was considered likely pathogenic (PSV1+PM2). Sanger sequencing verified the heterozygous mutation of CPOX in the proband, although it was not detected in her father. WES also identified 62 other gene variants, especially two heterozygous variants in SLC7A7 (NM_001126106): c.250G > A (p. V84I) and c.625+1G > A (splicing). DEGs were detected from GSE51997, and the expression of CPOX was downregulated in SLE patients compared with normal controls (adj. P = 0.0071, logFC = −1.0975). Conclusion. This study presents the first reported case of SLE coexisting with HCP in China; moreover, a novel splicing mutation of CPOX, i.e., c.700+2 T > C (intron 2), and two heterozygous mutations of SLC7A7 were reported. The simultaneous mutations of CPOX and SLC7A7 may explain the etiopathogenetic connections of HCP and SLE.
Assessment of Risk Tendency of Coal Bursting Pressure in Deep Outburst Seam
Authors: Gu Beifang , Wang Longkang , Zhang Minbo
Published: May 2022

In order to analysis the mechanism of coal bursting pressures of deep coal seams and take effective methods to identify, monitor, and control coal bursting pressure, this paper takes 21101 working face of No. 2 coal seam in Dongpang Coal Mine as an example. Risk identification is carried out for the hazardous and harmful factors of coal bursting pressure in coal seam 21101 in Dongpang Coal Mine, and each influencing factor is classified. The hierarchical structure model of the influencing factors of coal bursting pressure in coal seam protruding deep in Dongpang Coal Mine is established in combination with expert opinions, and the weight of each level index is calculated by MATLAB software. The results show that the 21101 working face of No. 2 coal seam in Dongpang Coal Mine has strong impact risk, and the main risk factors include geological structure, impact resistance of coal and rock, mining stress, inducing factors, and emphasis degree of impact risk. According to the results, the corresponding safety measures are put forward to prevent the damage caused by coal bursting pressure in advance and ensure the high quality and safe production in the mine. The qualitative and quantitative methods are used to make the evaluation process more reasonable and scientific. The method could effectively analyze the main factors affecting coal bursting pressure and put forward corresponding safety measures for the main risk factors.
Anti-Risk Ability of Government Purchasing Elderly Care Services under the Coordination of Complex Network and GERT
Authors: Lu Zhengnan , Zhang Yuting , Xu Lan
Published: May 2022

Risk problems of government purchasing elderly care services occur frequently. In order to open the “black box” of decision-making regarding the risks, this study explores the anti-risk ability of government purchasing elderly care services from the perspective of complex network and graphical evaluation review technique (GERT). Firstly, network of government purchasing elderly care services is established, which consists of link level and level of risk factors. Secondly, GERT is employed to analyze the anti-risk ability of the link level of the policy. Then combined with complex network theory, propagation process of risks is simulated at the level of risk factors and anti-risk ability of the complex network consisting of risk factors is explored. Results show that the anti-risk ability of each link in government purchasing elderly care services is obtained, which provides the priority for managers to conduct the risk management. And compared with the ani-risk ability under the random risk attack and deliberate risk attack, the anti-risk ability under the risk attack based on links is obviously lower.
Risk Factors of Total Blood Loss and Hidden Blood Loss in Patients with Adolescent Idiopathic Scoliosis: A Retrospective Study
Authors: Li Xiangyu , Ding Wenyuan , Zhao Ruoyu , Yang Sidong
Published: May 2022

Objectives. To investigate the risk factors of total blood loss (TBL) and hidden blood loss (HBL) in adolescent idiopathic scoliosis (AIS) patients undergoing posterior orthopedic surgery. Methods. The AIS patients who visited department of spine surgery between January 2015 and December 2020 were retrospectively reviewed. Those with a history of posterior orthopedic surgery for AIS were identified, and their clinical data were collected. Gross formula was used to calculate the TBL and HBL. SPSS 20.0 was used for statistical analysis. The potential risk factors of TBL and HBL were assessed by independent t‐test or univariate analysis. The risk factors of TBL and HBL were determined by multiple linear regression. Results. A total of 114 patients were included in this study. Operative time (P < 0.001), postoperative platelets (PLT) (P = 0.001), the number of surgical fixation segments (P < 0.001), implanted screws (P < 0.001), hospital stay (P = 0.006), type of scoliosis (P < 0.001), and correction angle of scoliosis (P = 0.063) were the potential risk factors of TBL. Operative time (P < 0.000), postoperative PLT (P = 0.095), the number of surgical fixation segments (P < 0.001), implanted screws (P < 0.001), type of scoliosis (P < 0.001), correction angle of scoliosis (P = 0.073), and total blood volume (P = 0.098) were the potential risk factors of HBL. Multiple linear regression analysis showed that operative time (P = 0.003) and the number of surgical fixation segments (P = 0.014) were risk factors of TBL, while the number of surgical fixation segments (P = 0.004) was a risk factor of HBL. Conclusions. In AIS patients undergoing posterior internal fixation surgery, the operative time and the number of surgical fixation segments are risk factors of TBL, and the number of surgical fixation segments is a risk factor of HBL. Surgeons need to consider these factors when making surgical strategies for AIS patients.
A New Generation Communication System Based on Deep Learning Methods for the Process of Modulation and Demodulation from the Modulated Images
Authors: Daldal Nihat , Sezer Zeynel Abidin , Nour Majid , Alhudhaif Adi , Polat Kemal
Published: May 2022

Demodulating the modulated signals used in digital communication on the receiver side is necessary in terms of communication. The currently used systems are systems with a variety of hardware. These systems are used separately for each type of communication signal. A single algorithm facilitates the classification and subsequent demodulation of signals without needing hardware instead of extra hardware cost and complex systems. This study, which aims to make modulation classification by using images of signals, provides this convenience. In this study, a classification and demodulation process is done by using images of digital modulation signals. Convolutional neural network (CNN), a deep learning algorithm, has been used for classification and recognition. Images of the signals of quadrate amplitude shift keying (QASK), quadrate frequency shift keying (QFSK), and quadrate phase shift keying (QPSK) digital modulation types at noise levels of 0 dB, 5 dB, 10 dB, and 15 dB were used. Thanks to this algorithm, which works without hardware, the success achieved is around 98%. Python programming language and libraries have been used in training and testing the algorithm. Demodulation processes of these signals have been performed for demodulation using the nonlinear autoregressive network with exogenous inputs (NARX) algorithm, an artificial neural network. As a result of using MATLAB, the NARX algorithm achieved approximately 94% success in obtaining the information signal. Thanks to the work done, it will be possible to classify and demodulate other communication signals without extra hardware.
Marked Hyperbilirubinemia Associated with Primary Myelofibrosis Responsive to Ruxolitinib
Authors: Sandhu Sunny , Chaudhry Hunza , Zhang Sharon , Prajapati Devang
Published: May 2022

Primary myelofibrosis (PMF) is a chronic myeloproliferative disorder seen in older adults which can present both with hepatosplenomegaly as well as mild nonspecific liver enzyme abnormalities. Mild elevations in bilirubin can occasionally be seen due to both intravascular hemolysis as well as extramedullary hematopoiesis. Marked hyperbilirubinemia as a presenting sign of PMF progression, however, has not been reported. We present the case of a patient with a remote diagnosis of PMF, who presented with marked hyperbilirubinemia with a notable response to ruxolitinib.
Model Construction of Hierarchical Polarization Characteristics Combined with Social E-Commerce Consumer Behavior
Authors: Zhang Quan , Yang Jian
Published: May 2022

In order to analyze the consumer behavior of social e-commerce, this article attempts to explore the irrational consumer behavior factors that affect the audience in the live broadcast of e-commerce Internet celebrities. This paper predicts and analyzes the consumption behavior of social e-commerce and combines the characteristics of hierarchical planning to intelligently process the system to improve the effectiveness of the system. Moreover, this paper constructs a social e-commerce consumer behavior prediction model based on hierarchical polarization characteristics, researches and analyzes multiple factors and performance, and builds an intelligent simulation model. The analysis of the test results shows that the social e-commerce consumer behavior prediction model based on the hierarchical polarization characteristics proposed in this article is effective and can play an important role in the prediction of social consumer behavior.
Analysis and Practice of Applying Oriented Teaching Method to Improve the Effect of College English Teaching
Authors: Yang Hua
Published: May 2022

The Ministry of Education of my country released the first “national standard” in January 2018, clearly stating that it is necessary to attach importance to and improve the ability of undergraduates. Through the analysis of the research results in this field at home and abroad, this study finds that the thinking ability training strategies that can be provided in the previous research are relatively scattered, and there is a lack of effective training methods and guidance. Therefore, Dr. Wen Qiufang proposed the teaching method of “production-oriented approach.” “Production-oriented approach” includes driving, promoting, and re-evaluation, in which the training content is integrated into each link. Therefore, this study combines training and Production-oriented Approach, and using this theoretical basis in the English teaching classroom can explore better. It provides a new way for the cultivation of college students’ English thinking ability. In the actual classroom teaching, the production-oriented teaching method is used to teach English to the students during the research process. After the teaching course is over, the teaching data are collected and analyzed with SPSS 25.0 software, and the data results are displayed. It can be seen that applying the Production-oriented approach to English classroom teaching can indeed improve the level of domestic college English students and provide a reference approach and method for students’ English training, and this method is effective and feasible.
Diagnosing Cancer Using IOT and Machine Learning Methods
Authors: Maray Mohammed , Alghamdi Mohammed , Alazzam Malik Bader
Published: May 2022

Breast cancer affects one in every eight women and is the most common cancer. Aim. To diagnose breast cancer, a potentially fatal condition, using microarray technology, large datasets can now be used. Methods. This study used machine learning algorithms and IOT to classify microarray data. They were created from two sets of data: one with 1919 protein types and one with 24481 protein types for 97 people, 46 of whom had a recurring disease and 51 of whom did not. The apps were written in Python. Each classification algorithm was applied to the data separately, without any feature elimination or size reduction. Second, two alternative feature reduction approaches were compared to the first case. In this case, machine learning techniques like Adaboost and Gradient Boosting Machine are used. Results. Before applying any feature reduction techniques, the logistic regression method produced the best results (90.23%), while the Random Forest method produced good results (67.22%). In the first data, SVM had the highest accuracy rate of 99.23% in both approaches, while in the second data, SVM had the highest rate of 87.87% in RLR and 88.82% in LTE. Deep learning was also done with MLP. The relationship between depth and classification accuracy was studied using it at various depths. After a while, the accuracy rate declined as the number of layers increased. The maximum accuracy rate in the first data was 97.69%, while it was 68.72% in the second. As a result, adding layers to deep learning does not improve classification accuracy.
Propagation of tunnelling cracks in composite materials under strain and force-controlled cyclic loading
Authors: Moncy A , Sørensen BF , Castro O , Berggreen C , Glud J
Published: May 2022

In this paper, the propagation of tunnelling cracks in composite laminates subjected to uniaxial force-controlled and strain-controlled cyclic loading is analysed considering both interacting and non-interacting cracking scenarios. Glass fibre reinforced polymer laminates with [Formula: see text] layup are used in the analysis. For non-interacting cracks, a strain-controlled test under a single strain value is found to be sufficient to produce the slope of the Paris-Erdogan law type curve relating the crack front growth rate (CGR) with the energy release rate (ERR), but within a limited range of ERR. Whereas, a force-controlled test is found more suitable when characterising the variation of the CGR at a certain ERR value. For closely spaced cracks, commonly seen crack interaction scenarios are identified and the CGR of the crack front is investigated for both loading control modes. It is found that the CGR decreases when volume averaged stresses are reduced ahead of the crack front due to shielding effect at high crack densities. A relationship between these two parameters is presented. It is further found that the CGR of two collinear crack fronts growing towards each other for coalescence do not influence each other. But when the two crack fronts are not collinear the CGR of the crack fronts is significantly affected after they have grown past each other.
Impact of Behavioral Interventions on Patient Activation in Adults with Hypertension: A Systematic Review and Meta-Analysis
Authors: Innab Adnan , Kerari Ali
Published: May 2022

Introduction: Behavioral interventions assist patients in maintaining optimal self-management of their health, especially in those at risk of certain conditions. Little is known about the effects of self-management interventions on patient activation in adults with hypertension. Therefore, this systematic review and meta-analysis aimed to evaluate how self-management strategies affect changes in activation levels in adults with hypertension. Methods: We searched online databases: PubMed, CINAHL, and Cochrane Central Register of Controlled Trials for studies published between January 2004 and May 2021. We included randomized controlled trials that assessed the effects of self-management interventions on patient activation in adults with hypertension and reported patient activation using the patient activation measure (PAM). Results: 4 Four studies (N = 1415 participants) met the inclusion criteria. In adults with hypertension, self-management interventions improved patient activation with moderate strength of evidence. A community-based self-management program, motivational interviewing strategies, and home-based patient-activated care were associated with better PAM scores than usual care. Conclusion: Our findings reinforce the need for healthcare providers to incorporate these interventions into primary care to support the adoption of recommended hypertension self-management behaviors. Future studies must focus on tailoring support to the patient’s level of activation in hypertension self-management.
“But There’s Only So Much You Can Do…” Parent Support-Giving within the Context of Peer Victimization
Authors: McWood Leanna M. , Frosch Cynthia A. , Wienke Garrison Christine M. , Erath Stephen A. , Troop-Gordon Wendy
Published: May 2022

Little is known regarding the processes that occur when parents support their child who is being victimized by peers. The current study utilized in-depth interviews with 11 fourth- through sixth-grade early adolescents and their mothers as to the processes that occurred when the mothers attempted to help their child cope with peer victimization. Findings indicated a support-giving process that often started after initial disclosure of the victimization and continued for months or even years. Mothers’ responses included teaching their child how to respond to peer victimization, actively intervening, and enacting compensatory behaviors. Dyads reported individual and joint evaluation of the effectiveness of responses, and participants emphasized the role of communication for effective coping. A conceptual framework is presented to help generate novel lines of inquiry into the processes that occur when parents assist their peer-victimized adolescent and examine the applicability of the findings to more diverse samples and family climates.
Learning losses and educational inequalities in Europe: Mapping the potential consequences of the COVID-19 crisis
Authors: Blaskó Zsuzsa , Costa Patricia da , Schnepf Sylke V
Published: May 2022

It is widely discussed that the pandemic has impacted educational inequalities across the world. However, in contrast to data on health or unemployment, data on education outcomes are not timely. Hence, we have extremely limited knowledge about pandemic-related learning losses at the national and cross-national levels. As it might take years to get suitable comparative data, this study uses the latest large-scale international achievement survey from before the pandemic, the Trends in International Mathematics and Science Study 2019, to answer two research questions. First, which European countries are most likely to have experienced higher learning loss among their children? Second, which European countries have most likely experienced the greatest increases in learning inequalities? Results based on 4th graders’ school achievements indicate that educational inequalities between and within countries are likely to have augmented substantially throughout Europe. Some European countries are probably already facing an education crisis.