bluuebunny/crossref_metadata_2025 huggingface dataset:
Tolerância ao fenantreno por fungos isolados de uma reserva ecológica de Mato Grosso, Brasil
Authors: Schneider Giovana , Souza Felipe Soares de , Oliveira João Arthur dos Santos , Souza Hilton Marcelo de Lima
Published: December 2021

A seleção de espécies com potencial em degradação de Hidrocarbonetos Policíclicos Aromáticos (HPAs) é uma etapa fundamental para o sucesso em programas de biorremediação. Entre alguns métodos, o teste de tolerância ao contaminante de interesse tem auxiliado os pesquisadores na obtenção de organismos com potencial em degradar HPAs. Dessa forma, o objetivo deste trabalho foi analisar o potencial de fungos, isolados de uma reserva ecológica do Centro-Oeste brasileiro, em tolerar fenantreno, um HPA de elevada toxicidade e encontrado em petróleo e seus derivados. Para tanto, discos da cultura dos fungos (8mm), obtidos após 7 dias de crescimento em MEA 2%, foram transferidos para placas de Petri contendo MEA 0,2%, após inoculação superficial com cristais de fenantreno e incubados a 28 °C. O crescimento micelial foi medido por um período de 10 dias na ausência e presença de diferentes concentrações de fenantreno (200 µg/mL, 600 µg/mL e 1000 µg/mL), em triplicata. Os dados foram analisados através da taxa de crescimento fúngico (CF), inibição de crescimento fúngico (ICF) e Análise de Variância (ANOVA) seguida do Teste de Tukey (p>0,05). Ao décimo dia de crescimento, Phanerochaete australis SA18, Disporotrichum dimorphosporum SA09 e Lentinus crinitus SA37 se destacaram, com as maiores CF e baixa ICF, consequentemente. P. australis tolerou todas as diferentes concentrações de fenantreno e destacou-se estatisticamente dos demais fungos. A partir desse resultado, sugere-se novos estudos com P. australis, sobre produção enzimática, capacidade de degradação e produção de metabólitos de fenantreno.
Resultados da aplicabilidade de um protocolo de rastreamento populacional de câncer de próstata em Chapecó-SC
Authors: Andrade Gustavo Henrique , Pagnussatt Luiza , Fabiani Thalis Matheus , Zeni Marcelo , Lutinski Junir Antonio
Published: December 2021

Campanhas que estimulam o rastreamento do câncer de próstata no Brasil são realizadas anualmente e preconizam o uso do toque retal associado à dosagem sérica do antígeno prostático específico. Objetivo: Avaliar os resultados e a aplicabilidade de um protocolo de rastreamento do câncer de próstata em Chapecó-SC. Métodos: Foram analisados dados clínicos de questionários de perfil epidemiológico e testes de dosagem de PSA de 249 homens, acima de 45 anos, residentes de Chapecó-SC e conveniados à Unimed, por meio de consulta ao banco de dados e exames do laboratório do Hospital Unimed Chapecó. Resultados: A amostra foi composta por 249 homens cuja média de idade foi de 51,2 anos. A média de valor do PSA da amostra foi de 0,82 ng/dL e 3,2% dos pacientes tiveram seu resultado acima de 2,5 ng/dL. 14,05% possuem histórico de parente de primeiro grau com câncer de próstata. Discussão: Evidências sugerem que não é necessário realizar o rastreio para câncer de próstata. Todavia, nos Estados Unidos, a US Preventive Services Task Force recomendou a não realização do rastreio e houve um aumento de metástases à distância do câncer de próstata em indivíduos com idade superior a 75 anos. A recomendação mais atual indica que deve ser feito de forma individualizada em pacientes entre 55 e 69 anos, para diagnóstico em estágio inicial e redução do sobrediagnóstico e overtreatment. Conclusão: Diante dos dados apresentados, a individualização no rastreamento é mais importante que o rastreamento populacional indiscriminado.
O uso de psicofármacos em jovens universitários
Authors: Wilkon Nickson Willian Vedigal , Rufato Fabrício Duim , Silva Willian Rufato da
Published: December 2021

O adoecimento psíquico em jovens universitários e o suo de psicofármacos nesta população tem ganhado destaque em estudos atuais. Os diagnósticos de transtornos mentais comuns, como ansiedade e a depressão são encontrados na maioria dos estudantes, e quando não tratados esses sintomas podem desencadear prejuízos maiores. Portanto, este estudo objetivou realizar um levantamento bibliográfico dos últimos cinco anos de estudos relacionados ao uso de psicofármacos no ensino superior. A busca foi realizada nas bases da CAPES, Scielo e Google Acadêmico, utilizando as palavras-chaves: psicofármacos; acadêmicos; farmácia; saúde do estudante e prevalência. Foram selecionados dez estudos entre artigos, teses e dissertações. Observou-se que a prevalência de adoecimento mental está no sexo feminino. Grande parte deste público faz uso de medicamentos antidepressivos, calmantes e estimulantes para tratar sintomas depressivos, ansiedade, dificuldade para dormir e para aumento do rendimento acadêmico. Muitos estudantes fazem o uso por indicação de amigos ou terceiros sem prescrição médica.  O estresse cotidiano, as exigências acadêmicas, conciliar trabalho e estudo e condições socioeconômica desfavoráveis contribuem para o adoecimento psíquico.
Alimentos transgênicos: Benefícios, malefícios e controvérsias
Authors: Barros Barbára Maciel de , Oliveira Bruna Moura de , Silva Maria Cláudia da
Published: December 2021

O consumo de alimentos transgênicos aumentou nas últimas duas décadas, a partir de alterações genéticas produzidas em laboratórios, através de técnicas artificiais de engenharia genética em plantas, animais e microorganismos. Baseado nisto, este trabalho utilizou a metodologia de revisão bibliográfica para se entender melhor a respeito deste consumo. De acordo com os artigos pesquisados os organismos transgênicos não trazem mal para a saúde humana, a fim de ter uma menor quantidade de agrotóxicos em seus alimentos, ajudando no processo de conservação e produção de suas plantações. Concluindo-se que os alimentos transgênicos estão trazendo mais benefícios do que malefícios para a população.
Affordances de crianças do semiárido nordestino residentes em casas e apartamentos
Authors: Nunes Marcília Ingrid Lima Barroso , Silva Antonio Eduardo de Oliveira , Pequeno Livia Kallahan Soares , Cunha Renata Micaella de Oliveira , Santos Ramile Cristyan dos , Gobbi Alycia Dannyela de Lima Silva , Souza Marcelo Gomes de , Mendes Marcos Aurélio da Silva , Nunes Ana Camila Campelo de Albuquerque
Published: December 2021

O ambiente domiciliar é apontado como principal fator que influencia no desenvolvimento infantil. Podemos compreender o Affordance como sendo um conjunto de oportunidades que conferem desafios ao indivíduo em desenvolvimento. O objetivo deste estudo foi averiguar os níveis de oportunidades motoras (affordances) de crianças que moram em casa ou apartamento. Estudo descritivo transversal, contou com uma amostra de 49 tutores voluntários de crianças de ambos os sexos que se encontraram na faixa etária entre 18-42 meses. O instrumento utilizado para avaliar o nível de oportunidades para o desenvolvimento motor das crianças foi o questionário Affordances in the Home Environment for Motor Development (AHEMD – 18-42 meses). Após a aplicação do questionário, os dados coletados foram inseridos e classificados com o auxílio de uma aplicação do programa Microsoft Excel (AHEMD Calculador VPbeta1.5.xls). A casa, obteve valores significativamente maiores quando comparado com o ambiente apartamento, exceto nos materiais de motricidade fina e grossa. Acreditamos que crianças que vivem em casas, tenham maiores oportunidades motoras em relação às crianças residente em apartamentos, o que pode refletir no desenvolvimento motor infantil ao longo da infância.
Application of 3-dimensional printing implants for bone tumors
Authors: Park Jong Woong , Kang Hyun Guy
Published: December 2021

Three-dimensional (3D) additive manufacturing has recently been used in various medical fields. Among them, orthopedic oncology is one that utilizes it most actively. Bone and tumor modeling for surgical planning, personalized surgical instrument fabrication, and implant fabrication are typical applications. The 3D-printed metal implants using titanium alloy powder have created a revolutionary change in bone reconstruction that can be customized to all body areas; however, bioprinting remains experimental and under active study. This review explores the practical applications of 3D printing in orthopedic oncology and presents a representative case. The 3D-printed implant can replace the conventional tumor prosthesis and auto/allobone graft, thereby personalizing bone reconstruction. Biologic bone reconstruction using biodegradable or bioprinted materials beyond metal may be possible in the future.
Phytochemical screening and antibacterial activity of essential oils of Cymbopogon
citratus and Ocimum americanum : a comparative account
Authors: Mehta R. , Yadaw Nishtha , Khan Naureen S. , Sen K. K. , Chaurasia B.
Published: December 2021

The present study highlights the extraction of essential oils from C. citratus and O. americanum using Microwave Hydrodiffusion and Gravity method (MHG) and Hydrodistillation Method (HD), the qualitative and quantitative screening along with determination of antibacterial potential. For the study, extraction of essential oils was performed using Microwave Hydrodiffusion and Gravity method and Hydrodistillation Method. Comparative study was performed to check the total flavonoid content (TFC), total phenolic content (TPC), biochemical test, thin layer chromatography (TLC) and determination of antibacterial activity of the essential oils. The results of the study depicted that the MHG method for extraction of essential oils was much better compared to extraction by HD method as supported by the biochemical tests, TFC, TPC and TLC results. However, the essential oils did not show antibacterial activity. More study related to the antimicrobial activity needs to be performed. Essential oils form an integral part of the pharmaceutical and healthcare industry hence, detailed study regarding the isolation and application of essential oils is required. The present study suggests the use of MHG method for extraction of essential oils.
Assessment of spider richness in the campus of Sree Vidyadhi Raja N.S.S. College,
Kottayam (Kerala) India
Authors: Jayakumar K. , Sini B.P. , Sudhikumar A.V.
Published: December 2021

Present study investigated spider richness in the campus of S.V.R N.S.S College Kottayam, Kerala. A checklist of 110 species belonging to 77 genera and 19 families has been prepared. Salticidae dominated the population with 25 genera. Among the feeding guild type 37.27% of the documented spiders belong to Stalkers. Some of the spiders collected are endemic to India such as Camaricus khandalaensis, Arachnura angura, Lycosa tista, Oxyopes sunandae, Meotipa multuma and Chalcotropis pennata. High species richness of spider in the campus proposes to consider and implement suitable conservation plans at the earliest.
Bio-monitoring a future tool for environmental studies
Authors: Dixit Mukesh , Shrivastav Neerja , Pani Subrata
Published: December 2021

The present paper is prepared to discuss the significance of utilizing bio-monitoring tool for environmental monitoring vis-a-vis conventional physico-chemical analysis. The innovative approach of bio-monitoring study is considered to be more effective by many environmental scientists as outcome of the study depicts more logical conclusion based on presence or absence of certain aquatic organisms which indicate the degree of pollution of an aquatic ecosystem.
Effect of phosphorus and zinc supplementation on growth, yield attributes and yields on
pea (Pisum sativum) in district Jhansi (UP) India
Authors: Singh Satyavir , Sahu Anil Kumar , Dayal Guru , Saurabh Saurabh , Singh Sanjay
Published: December 2021

A field experiment was conducted during winter season at Organic Research Farm Kurguan ji, Deptt. of Soil Science and Agricultural chemistry, Institute of Agricultural Sciences, Bundelkhand University, Jhansi (U.P.) on red soil (Parwa) to study the effect of phosphorus and zinc application with four levels of each on pea crop. Application of 120 kg ha-1 P and 30 kg ha-1 Zn produced highest values and their percentage increment in respect to plant height (102.2 cm:10.3% and 97.9 cm:7.8%), no of branches (23.4 : 33.71% and 22.6: 31.39%), pod length (6.4 : 56.1% and 5.8 : 48.71%) and no of pods per plant (25.8 : 21.12% and 26 : 1.30.5%) respectively, over control followed by P2 (90kg ha-1), P1 (60 kg ha-1) and Zn2 (15 kg ha-1) and Zn1 (7.5 kg ha-1). The application of 120 kg ha-1 phosphorus treatment is proved as most superior among treatments. On the basis of analysis of soil samples after harvesting indicated neutral in reaction, safe in soluble salt concentration, low in organic carban and Nitrogen, medium in Phosphorus and Zinc, high in potash in present study.
First report of Rhipicephalus deltoideus from Manipur, India
Authors: Singh Aheibam Jeeran Kumar , Singh R.K. Gambhir
Published: December 2021

The present paper deals record of a Rhipicephalus tick, reported for the first time from Manipur, a new record of India. The species under this genus have usual morphological features viz., having a hard sclerotized scutum which completely cover the dorsal surface of the body in males but present a small shield just behind the capitulum in female, basis capitulum is hexagonal in shape, mouth part anterior in position, eyes if present are located near the lateral margin of the scutum, presence of adanal plate in male, presence of festoons, etc. The present specimen which is reporting as a new record was collected from cattle (Bos indicus) from Wakha (24º46'22'’ N, 93º59'12'’E) Imphal East District, Manipur,India. On detailed microscopic observation, the present specimen was found to possess the morphological characters similar to the already known Rhipicephalus species, Rhipicephalus deltoides is a first record from India.
Biochemical Alterations Due to dimethoate in fresh water fish, Channa punctatus
Authors: Paithane K.T. , Bhandare R.Y. , Shinde S.E. , More P.R. , Pathan T.S.
Published: December 2021

Activity of a few biomarkers have been investigated on fresh water fish, Channa punctatus exposed to three sub – lethal concentrations of dimethoate(1/5, 1/10 and 1/15 of 96hrs LC50 values). The alteration in protein contents of liver, gill and muscle were investigated. The protein levels were found to be depleted in all the tissues after exposure to dimethoate over the control.All the organs showed the significant difference between control and exposed groups in all the estimated parameters on long exposure. The present study considers biochemical parameters as important biomarkers in determining the level of toxicity caused by the pesticide Dimethoate. Therefore the detailed results and observations are summarized in the present investigations.
Dental Anxiety Management by Full Spectrum CBD Formulations: Dual Dosing (AM/PM) Protocol in A Real-World Setting
Authors: DL Cooper , R Stephan , CW Maygar
Published: December 2021

Background: Dental Anxiety (DA) may produce a vicious cycle where dental problems are not adequately serviced. Chronic non-compliance with prescribed dental care and maintenance is associated ultimately with poor dental health. Current pharmacologic treatments such as benzodiazepines for DA are associated with poor efficacy and significant side effects.The anxiolytic effects of the most studied cannabinoid, cannabidiol (CBD) in the Dual Dosing (AM/PM) Full Spectrum Protocol are detailed here (DDFSP). Materials and methods: Our recently developed PhytoDental Solutions Dental Anxiety Scale (PDSDAS) composed of eight self-reported psychic, somatic and sleep indicators was utilized for scoring a subject’s DA level for three Time Groups (TG): the night before (T0); immediately after (T1); and 24 hours (T2) after a dental procedure or visit. Results: In this series of subjects completing at least one post-dosing time point, the Dual Dosing AM/PM Full Spectrum CBD (DDFSCBD) Protocol significantly reduced both psychic (43% to 67%) and somatic (51%) dental anxiety. Additionally, 87% of study patients reported substantially improved sleep the night before their dental visit. Kruskai-Wallis one-way ANOVA analysis of the three Time Group data sets yielded significant 1-tail statistical differences (p-values< 0.05) with p-values of 0.020 and 0.041 substantiating the role of the DDFSP to modify DA. Further, validation of the PDSDAS as a scoring measure developed for DA was extended by paired t-test comparisons to multiple smaller Paired Data sets across these Time Groups yielding 1-tail p-values of 0.010, 0.050 and 0.024 respectively. Conclusion: Determination of significance by both ANOVA and paired t-tests of PDSDAS scoring strongly suggest the Dual-Dosing (AM/PM) Full Spectrum Protocol is an effective Dental Anxiety anxiolytic.
Опыт применения автоматизированных станций мониторинга на уникальных строительных объектах
Authors: ГУРЬЕВ Владимир Владимирович , ГРАНЕВ Виктор Владимирович , ДМИТРИЕВ Александр Николаевич , ДОРОФЕЕВ Владимир Михайлович , КЕЛАСЬЕВ Николай Геннадьевич , ЛЫСОВ Дмитрий Анатольевич
Published: December 2021

Статья посвящена анализу опыта применения автоматизированных станций мониторинга на уникальных строительных объектах. Рассмотрены нормативная база и технические решения систем мониторинга состояния уникальных зданий и сооружений. Представлены результаты особенностей применения станций мониторинга технического состояния высотных зданий и зданий с большепролетными конструкциями. Отмечено, что для мониторинга состояния высотных объектов применяют способы, основанные на анализе передаточных функций различных частей здания. Установлено, что методы контроля напряженно-деформированного состояния большепролетных конструкций зданий должны позволять производить сравнение текущих значений с ранее полученными по соответствующему контролируемому параметру конкретной строительной конструкции, а также со значениями, вычисленными с помощью математического моделирования для различных случаев нагружения строительной конструкции, характеризующих ее предельную проектную несущую способность. Приведены особенности станций мониторинга для уникальных зданий, построенных в сейсмических районах страны. Представлены методология проектирования таких станций, отечественные аппаратные средства и программное обеспечение современных станций мониторинга технического состояния уникальных зданий и сооружений.
Мониторинг и анализ нормативных документов по проектированию конструкций с учетом прогрессирующего обрушения
Authors: ЕРЕМЕЕВ Павел Георгиевич , ЛЕБЕДЕВА Ирина Владимировна
Published: December 2021

Проведен анализ отечественных и зарубежных нормативно-технических документов, содержащих требования по защите зданий и сооружений от прогрессирующего обрушения. Выявлены избыточные и противоречащие друг другу требования различных российских нормативных документов по этой проблеме, в том числе для производственных и большепролетных объектов. Показано, что расчет на прогрессирующее обрушение следует проводить только для многоэтажных зданий. Представлены различные методы защиты зданий или сооружений от прогрессирующего обрушения. Подготовлены предложения по гармонизации российских и зарубежных нормативных документов. Рассмотрены основные положения по правилам проектирования зданий и сооружений различных конструктивных систем и функционального назначения при аварийной расчетной ситуации. Исследованы вопросы предельных состояний конструкций, соответствующих нагрузок, воздействий и их сочетаний, рекомендаций по обеспечению безопасности и способов защиты зданий и сооружений от прогрессирующего обрушения.
Организация претензионно-исковой работы в строительстве
Authors: ЛАЗАРЕВА Наталья Валериевна , ЗИНОВЬЕВ Алексей Юрьевич , ОПАРИНА Людмила Анатольевна
Published: December 2021

Рассмотрена организация претензионно-исковой работы в строительных компаниях, которая направлена на объективное и справедливое разрешение конфликтных ситуаций между участниками строительства. Основной инструмент данной системы - строительно-техническая экспертиза. Исходя из институциональной принадлежности различают судебные, досудебные и корпоративные строительно-технические экспертизы. В статье приводятся последовательность процедур их реализации в зависимости от проявления характера несоответствий (моногенных или полигенных). Междисциплинарный характер и многофакторность строительно-технической экспертизы определяют вариативность схем взаимодействия в рамках претензионно-исковой работы по отношению к объекту экспертизы - зависимая, аффилированная и независимая строительно-техническая экспертиза. Предполагается, что возможным дальнейшим развитием претензионно-исковой работы станет ее информатизация, т. е. применение информационных моделей объектов капитального строительства. Сделан вывод о том, что для дальнейших обоснований перспективности и целесообразности использования в выбранной предметной области информационных моделей необходимо исследование нормативных основ и существующих практик проведения строительно-технической экспертизы.
Effects of Si and Sn Contents and Heat-Treatment Temperature on the Corrosion Behavior of AISI 439 Ferrite Stainless Steel
Authors: Kim Chan Yang , Kim Do hyung , Chung Won sub
Published: December 2021

This study was conducted to evaluate the corrosion resistance and optimize the heat-treatment process of AISI 439 ferrite stainless steel silicon and tin alloys with reduced chromium. The microstructure of the specimens and deposition under each condition were analyzed. The production of oxide films was compared based on the thickness of the film and the change in the contents of each element. In addition, electrochemical analyses of each heat-treatment condition was used to quantitatively compare corrosion resistance and passive film stability based on the relative chromium, silicon, and tin contents. It was found that the addition of silicon and tin compensated for the decrease in corrosion resistance induced by the chromium reduction. The addition of the two elements inhibited iron (Fe) oxide production in the surface oxide film, thereby improving the corrosion resistance of the material and improving the stability of the passive film. Moreover, the SiO2 and SnO2 layers inhibited the production of Fe oxide and contributed to the stability of the film along with Cr2O3, the main component of the passive film. However, when the heat treatment temperature increased above a specific temperature, the oxide inhibitory effect of the two elements was relatively offset. Nevertheless, further research to optimize the content of the three elements will help develop materials with superior mechanical properties and corrosion resistance.
Thermal Properties of Copper Matrix-Ceramic Filler Composite Prepared by Polymer Solution Method
Authors: Oh Bok-Hyun , Ma Chung-Il , Kwak Ji-Yeon , Kong Heon , Lee Sang-Jin
Published: December 2021

A copper (Cu) metal-ceramic filler composite with high thermal conductivity and a suitable thermal expansion coefficient was designed for application as a high-performance heat dissipation material. The purpose of the designed material was to utilize the high thermal conductivity of Cu while lowering its high coefficient of thermal expansion by using a ceramic filler. In this study, a Cu-sol containing a certain amount of AlN or SiC ceramic filler was prepared using a non-aqueous solvent. A complex was produced by applying a PVB polymer to prepare a homogeneous precursor. The composite sintered without pressure in a reducing atmosphere showed low thermal conductivity due to residual pores, but the hot press sintered composite exhibited improved thermal conductivity. The Cu composite with 30 wt% AlN filler added exhibited a thermal conductivity of 290 W/m·K and a thermal expansion coefficient of 9.2 × 10-6/oC. Due to the pores in the composite, the thermal conductivity showed some difference from the theoretical value calculated from the rule of mixture. However, the thermal expansion coefficient did not show any significant difference.
Effect of Dissolution of η′ Precipitates on Mechanical Properties of A7075-T6 Alloy
Authors: Kim Young-We , Jo Yong-Hee , Lee Yun-Soo , Kim Hyoung-Wook , Lee Je-In
Published: December 2021

The effects of dissolution of the η′ phase by solution treatment on the mechanical properties of A7075-T6 alloy were investigated. Immediately after solution treatment of the T6 sheet at 450 oC or higher, elongation significantly increased and dissolution of the η′ phase occurred. η′ is the main hardening phase. After natural-aging, GPI, which is coherent with the aluminum matrix, was formed and strength increased. When bake hardening after natural-aging was performed, the yield strength slightly increased due to partial dissolution of the GPI and re-precipitation of the η′ phase. In contrast, after solution treatment at 400 oC, there was less elongation increase due to the precipitation of the coarse η phase at grain boundaries and low dissolution of the η′ phase. In addition, when bake hardening after natural-aging was performed, the yield strength decreased due to insufficient GPI, which is the nucleation site of the η′ phase. To promote reprecipitation of the η′ phase, the solution treatment temperature was set to a level that would increase solubility. As a result, the yield strength was significantly increased through re-precipitation of a large number of fine and uniform η′ phase. In addition, to increase the effect of dissolution, a pre-aging treatment was introduced and the bake hardenability can be improved after dissolution.
The Acting Class and the Myths of Meritocracy
Authors: O'Neill Deirdre , Wayne Mike
Published: December 2021

Our feature documentary The Acting Class (2017) is here contextualised in the context of a critique of the cultural industries as part of the ideology of meritocracy and a resurgence of work around class in the sociology of culture. The Acting Class focuses on the question of class stratification in the UK acting industry. We here review our research on this issue and contextualise it within the scholarly literature on diversity and inequality, the creative industries and the broader reconfigurations of the political economy of British capitalism.

We also discuss the importance of the interview in creative practice research as a way of democratising knowledge production and socialising experience.
Under Suspicion: Christine Brooke-Rose, Intelligence Work, and the Theory Wars
Authors: Guy Adam
Published: December 2021

This article looks at Christine Brooke-Rose's late work of life-writing, Remake (1996) and its depiction of Brooke-Rose's wartime experience working in the Allied code-breaking centre at Bletchley Park. I situate Remake's recall of Bletchley Park within a textual matrix that includes Brooke-Rose's own academic writing of the 1980s–90s, as well as texts that emerged out of the so-called ‘Theory Wars’ of the same period – especially relating to the revelation of Paul de Man's collaborationist journalism. In this range of writing, I trace a set of common concerns regarding personal history, suspicion, secrecy, disclosure, and mastery that herald a turn towards other forms of knowing. In doing so, I locate Remake at a crucial juncture in the emergence of our present post-critical moment.
The Effect of Working Capital Management on Profitability: Evidence from Malaysian Construction Firms
Authors: You Chooi Yin
Published: December 2021

Working capital management is an essential part of a sound business. The main objective of this research is to investigate the effect of working capital management on profitability. The regression analysis was carried out on a panel sample of 30 construction firms listed on Bursa Malaysia over a five-year period from 2015 to 2019. The findings suggest that there is a significant positive relationship between Days Inventory Outstanding (DIO) and Gross Operating Profit (GOP) as well as a significant negative relationship between Days Payables Outstanding (DPO) and GOP. Thus, firms can maximise their profitability by maintaining higher inventory level and paying off creditors in a shorter time frame.
Determination of dependence of gravitational interaction force of bodies on their velocity
Authors: Gribkov Andrey
Published: December 2021

This article presents the results of testing the hypothesis of the dependence of gravity on the velocity of motion of bodies. The numerical simulation clearly confirmed the correspondence of the calculated and observed values of the precession of orbit pericentres in binary systems including pulsars, as well as planets of the solar system. Based on the revealed dependence of the gravitational force on the velocity, the article describes a new effect of the precession of the centres of binary systems, which should be found as a result of further practical research.
Семья: традиции и современность (этнология, социология, история)
Authors: БЕГИЧЕВА ОЛЬГА ЛЬВОВНА , ВЛАСОВА НАТАЛЬЯ АЛЕКСАНДРОВНА , КАРПОВА ЕЛЕНА ГРИГОРЬЕВНА , КОВАЛЬ ТАТЬЯНА БОРИСОВНА , КОЛОСОВА О.А. , КОРШУНОВ АНАТОЛИЙ МИХАЙЛОВИЧ , КОТОВСКАЯ МАРИЯ ГРИГОРЬЕВНА , КРЫЛОВА НАТАЛИЯ ЛЕОНИДОВНА , КУРТО ОЛЬГА ИГОРЕВНА , ЛЮБАРТ МАРГАРИТА КЕМАЛЬЕВНА , ПЕРЕПЕЛКИН ЛЕВ СТАНИСЛАВОВИЧ , ПУШКАРЕВА НАТАЛЬЯ ЛЬВОВНА , ТИХОНОВА ЕЛЕНА ВИКТОРОВНА , ФАЙНБЕРГ Л.А. , ШАЛЫГИНА НАТАЛЬЯ ВАЛЕНТИНОВНА , ШВЕЦ ЭЛИНА ГРИГОРЬЕВНА
Published: December 2021

Коллективная монография подготовлена по результатам Московской региональной конференции на тему «Традиции, культура и трансформация семейных ценностей», которая состоялась 26 февраля 2021 г. в Российском государственном университете им. А.Н. Косыгина. Рассмотрены процессы эволюции семьи как в России, так и за рубежом. Книга предназначена для научных работников, преподавателей, аспирантов и студентов гуманитарных направлений, руководителей и специалистов государственных и общественных организаций, занимающихся проблемами семьи.
Omalizumab Reduces Unplanned Healthcare Interactions in Irish Patients With Chronic Spontaneous Urticaria
Authors: Ridge Katie , Redenbaugh Vyanka , Conlon Niall
Published: December 2021

Chronic spontaneous urticaria (CSU) is a common, debilitating skin disorder associated with impaired quality of life and psychological comorbidity. Symptoms can be difficult to control and many individuals will not respond to first line treatment. Due to the chronic and unpredictable nature of the disorder, patients frequently have repeated healthcare attendances. Despite this, little is known about healthcare resource utilization internationally. Furthermore, there is no Irish data to inform fundholding decision makers. Omalizumab is an anti IgE monoclonal antibody used in refractory urticaria. It is a comparatively high cost medicine and access to this treatment can be challenging. Recent assessments of omalizumab compared with usual care suggest that omalizumab is a cost-effective treatment for refractory urticaria. We carried out a retrospective review of 47 patients commenced on omalizumab. We evaluated unplanned primary and secondary care attendances and urticaria symptomatology before and after treatment. As expected, patients with refractory disease that were commenced on omalizumab had objective improvements in urticaria symptoms. Importantly, we show that this is reflected in a dramatic reduction in unplanned healthcare interactions at primary care and emergency departments. These data suggest that omalizumab may benefit these patients by reducing disease activity and thereby reducing the need for unplanned healthcare interactions.
Downregulated ADARB1 Facilitates Cell Proliferation, Invasion and has Effect on the Immune Regulation in Ovarian Cancer
Authors: Zhu Wei , Xu Zhijie , Huang Meiyuan , Wang Xiang , Ren Xinxin , Cai Yuan , Peng Bi , Liang Qiuju , Chen Xi , Yan Yuanliang
Published: December 2021

Ovarian cancer (OC) is typically diagnosed at an advanced stage and poses a significant challenge to treatment and recovery. Rencently, Adenosine deaminase RNA-specific B1 (ADARB1), an adenosine-to-inosine (A-to-I) RNA-editing enzyme, has been found to play an essential role in the development of cancer. However, the specific function of ADARB1 in ovarian cancer is still not fully understood. Here, we investigated the effects of ADARB1 on OC biology. By conducting bioinformatics analyses of several public databases, we found significantly decreased ADARB1 expression in OC cells and tissues. Moreover, RT-PCR and western blot showed lower ADARB1 expression in OVCAR3, HO8910pm and A2780 OC cells compared to human normal ovarian epithelial cell IOSE. Cell proliferation assay and clone formation assay showed that overexpression of ADARB1 (ADARB1-OE) inhibited the proliferation of tumor cells. Wound healing and transwell assay indicated that ADARB1-OE could suppress OC cell invasion and metastasis. Kaplan-Meier methods revealed that the patients with low level of ADARB1 displayed poor prognosis. TISIDB databases were further used to analyze the roles of ADARB1 in tumor-immune system interactions in OC patients. Furthermore, ADARB1-OE down-regulated the expression of phosphorylated AKT. Combination of ADARB1-OE and AKT inhibitor MK2206 exerted stronger cell growth inhibition. Thus, our investigation demonstrated that low levels of ADARB1 might be a potential target in the tumorigenesis and prognostic evaluation of OC patients.
Interleukin-17 Cytokines and Receptors: Potential Amplifiers of Tendon Inflammation
Authors: Mimpen Jolet Y. , Snelling Sarah J. B. , Carr Andrew J. , Dakin Stephanie G.
Published: December 2021

Interleukin (IL)-17A, a pro-inflammatory cytokine that is linked to the pathology of several inflammatory diseases, has been shown to be upregulated in early human tendinopathy and to mediate inflammatory and tissue remodelling events. However, it remains unclear which cells in tendons can respond to IL-17A, and how IL-17A, and its family members IL-17F and IL-17AF, can affect intracellular signalling activation and mRNA expression in healthy and diseased tendon-derived fibroblasts. Using well-phenotyped human tendon samples, we show that IL-17A and its receptors IL-17RA and IL-17RC are present in healthy hamstring, and tendinopathic and torn supraspinatus tendon tissue. Next, we investigated the effects of IL-17A, IL-17F, or IL-17AF on cultured patient-derived healthy and diseased tendon-derived fibroblasts. In these experiments, IL-17A treatment significantly upregulated IL6, MMP3, and PDPN mRNA expression in diseased tendon-derived fibroblasts. IL-17AF treatment induced moderate increases in these target genes, while little change was observed with IL-17F. These trends were reflected in the activation of intracellular signalling proteins p38 and NF-κB p65, which were significantly increased by IL-17A, modestly increased by IL-17AF, and not increased by IL-17F. In combination with TNF-α, all three IL-17 cytokines induced IL6 and MMP3 mRNA expression to similar levels. Therefore, this study confirms that healthy and diseased tendon-derived fibroblasts are responsive to IL-17 cytokines and that IL-17A induces the most profound intracellular signalling activation and mRNA expression of inflammatory genes, followed by IL-17AF, and finally IL-17F. The ability of IL-17 cytokines to induce a direct response and activate diverse pro-inflammatory signalling pathways through synergy with other inflammatory mediators suggests a role for IL-17 family members as amplifiers of tendon inflammation and as potential therapeutic targets in tendinopathy.
Myeloid-Derived Suppressor Cells: A Multifaceted Accomplice in Tumor Progression
Authors: Cheng Jia-Nan , Yuan Yi-Xiao , Zhu Bo , Jia Qingzhu
Published: December 2021

Myeloid-derived suppressor cell (MDSC) is a heterogeneous population of immature myeloid cells, has a pivotal role in negatively regulating immune response, promoting tumor progression, creating pre-metastases niche, and weakening immunotherapy efficacy. The underlying mechanisms are complex and diverse, including immunosuppressive functions (such as inhibition of cytotoxic T cells and recruitment of regulatory T cells) and non-immunological functions (mediating stemness and promoting angiogenesis). Moreover, MDSC may predict therapeutic response as a poor prognosis biomarker among multiple tumors. Accumulating evidence indicates targeting MDSC can reverse immunosuppressive tumor microenvironment, and improve therapeutic response either single or combination with immunotherapy. This review summarizes the phenotype and definite mechanisms of MDSCs in tumor progression, and provide new insights of targeting strategies regarding to their clinical applications.
Microfluidic Platforms for High-Throughput Pancreatic Ductal Adenocarcinoma Organoid Culture and Drug Screening
Authors: Geyer Marlene , Queiroz Karla
Published: December 2021

Pancreatic Ductal Adenocarcinoma (PDAC), the most common pancreatic cancer type, is believed to become the second leading cause of cancer-related deaths by 2030 with mortality rates of up to 93%. It is often detected at a late stage due to lacking symptoms, and therefore surgical removal of the tumor is the only treatment option for patients. Only 20% of the tumors are resectable, mainly due to early metastasis. Therefore, for 80% of cases chemotherapeutic treatment is the leading therapy for patients. PDAC is characterized by high-density stroma which induces hypoxic conditions and high interstitial pressure. These factors impact carcinogenesis and progression of PDAC and support the formation of an immunosuppressive microenvironment that renders this tumor type refractory to immunotherapies. Most in vitro PDAC models have limited translational relevance, as these fail to recapitulate relevant aspects of PDAC complexity. Altogether, there is an urgent need for novel and innovative PDAC modeling platforms. Here, we discuss the relevance of microfluidic and organoid technologies as platforms for modeling bio- and physicochemical features of PDAC and as translational models that enable high-throughput phenotypic drug screenings, while also allowing for the development of novel personalized models used to identify treatment responsive patient subsets.
An Automated and Highly Sensitive Chemiluminescence Immunoassay for Diagnosing Mushroom Poisoning
Authors: Zhu Jianyu , Dou Leina , Shao Shibei , Kou Jiaqian , Yu Xuezhi , Wen Kai , Wang Zhanhui , Yu Wenbo
Published: December 2021

Mushrooms containing Amanita peptide toxins are the major cause of mushroom poisoning, and lead to approximately 90% of deaths. Phallotoxins are the fastest toxin causing poisoning among Amanita peptide toxins. Thus, it is imperative to construct a highly sensitive quantification method for the rapid diagnosis of mushroom poisoning. In this study, we established a highly sensitive and automated magnetic bead (MB)-based chemiluminescence immunoassay (CLIA) for the early, rapid diagnosis of mushroom poisoning. The limits of detection (LODs) for phallotoxins were 0.010 ng/ml in human serum and 0.009 ng/ml in human urine. Recoveries ranged from 81.6 to 95.6% with a coefficient of variation <12.9%. Analysis of Amanita phalloides samples by the automated MB-based CLIA was in accordance with that of HPLC-MS/MS. The advantages the MB-based CLIA, high sensitivity, repeatability, and stability, were due to the use of MBs as immune carriers, chemiluminescence as a detection signal, and an integrated device to automate the whole process. Therefore, the proposed automated MB-based CLIA is a promising option for the early and rapid clinical diagnosis of mushroom poisoning.
Morphologic Alterations Precede Functional Hepatic Impairment as Determined by 13C-Methacetin Liver Function Breath Test in Adult Fontan Patients
Authors: Schleiger Anastasia , Kramer Peter , Sallmon Hannes , Jentsch Niklas , Pileckaite Marta , Danne Friederike , Schafstedde Marie , Müller Hans-Peter , Müller Tobias , Tacke Frank , Jara Maximilian , Stockmann Martin , Berger Felix , Ovroutski Stanislav
Published: December 2021

Objectives: Fontan-associated liver disease (FALD) is the most common end-organ dysfunction affecting up to 70–80% of the Fontan population. The clinical significance of FALD is incompletely understood and no unambiguous correlation between hepatic function and FALD severity has been established. In this study, we sought to evaluate maximal liver function capacity with liver maximum function capacity test (LiMAx®) in adult Fontan patients.

Methods: Thirty-nine adult Fontan patients (median age: 29.4 years [IQR 23.4; 37.4], median follow-up after Fontan operation: 23.9 years [IQR 17.8;26.4]) were analyzed in a cross-sectional observational study using LiMAx® test (Humedics GmbH, Berlin, Germany), laboratory testing, transient elastography (TE) and hepatic ultrasound. The LiMAx® test is based on the metabolism of 13C-methacetin, which is administered intravenously and cleaved by the hepatic cytochrome P4501A2 to paracetamol and 13CO2, which is measured in exhaled air and correlates with maximal liver function capacity.

Results: Maximal liver function capacity assessed by LiMAx® test was normal in 28 patients (>315 μg/h*kg) and mildly to moderately impaired in 11 patients (140–314 μg/h*kg), while no patient displayed severe hepatic impairment (<139 μg/kg*h). No correlation was found between maximal liver function capacity and hepatic stiffness by TE (r2 = −0.151; p = 0.388) or the presence of sonographic abnormalities associated with FALD (r2 = −0.204, p = 0.24). There was, however, an association between maximal liver function capacity and the laboratory parameters bilirubin (r2 = −0.333, p = 0.009) and γ-glutamyl transferase (r2 = −0.367; p = 0.021). No correlation was detected between maximal liver function capacity and the severity of FALD (r2 = −0.235; p = 0.152).

Conclusion: To the best of our knowledge, this is the first study to evaluate maximal liver function capacity using LiMAx® test in Fontan patients, which is a useful complementary diagnostic instrument to assess chronic hepatic injury. Maximal liver function capacity was preserved in most of our adult Fontan patients despite morphologic evidence of FALD. Moreover, maximal liver function capacity does not correlate with the extent of FALD severity evaluated by sonography or laboratory analysis. Thus, the development and progression of FALD in Fontan patients is not a uniform process and diagnostics of chronic hepatic injury during follow-up should encompass various modalities.
Upward Magma Migration Within the Multi-Level Plumbing System of the Changbaishan Volcano (China/North Korea) Revealed by the Modeling of 2018–2020 SAR Data
Authors: Trasatti Elisa , Tolomei Cristiano , Wei Lianhuan , Ventura Guido
Published: December 2021

Changbaishan volcano (China/North Korea border) was responsible for the largest eruption of the first Millennium in 946 CE and is characterized by a multi-level plumbing system. It last erupted in 1903 and presently consists of a cone with summit caldera. An unrest episode occurred between 2002 and 2006, followed by subsidence. Here, we analyze the Changbaishan 2018–2020 deformations by using remote sensing data, detecting an up to 20 mm/yr, NW-SE elongated, Line of Sight movement of its southeastern flank and a −20 mm/yr Line of Sight movement of the southwestern flank. This reveals an unrest occurring during 2018–2020. Modeling results suggest that three active sources are responsible for the observed ground velocities: a deep tabular deflating source, a shallower inflating NW-SE elongated spheroid source, and a NW-SE striking dip-slip fault. The depth and geometry of the inferred sources are consistent with independent petrological and geophysical data. Our results reveal an upward magma migration from 14 to 7.7 km. The modeling of the leveling data of the 2002–2005 uplift and 2009–2011 subsidence depicts sources consistent with the 2018–2020 active system retrieved. The past uplift is interpreted as related to pressurization of the upper portion of the spheroid magma chamber, whereas the subsidence is consistent with the crystallization of its floor, this latter reactivated in 2018–2020. Therefore, Changbaishan is affected by an active magma recharge reactivating a NW-SE trending fault system. Satellite data analysis is a key tool to unravel the magma dynamics at poorly monitored and cross-border volcanoes.
Dike Propagation During Global Contraction: Making Sense of Conflicting Stress Histories on Mercury
Authors: Crane Kelsey , Bohanon Allison
Published: December 2021

Thrust fault-related landforms, smooth plains units, and impact craters and basins have all been observed on the surface of Mercury. While tectonic landforms point to a long-lived history of global cooling and contraction, smooth plains units have been inferred to represent more punctuated periods of effusive volcanism. The timings of these processes are inferred through impact cratering records to have overlapped, yet the stress regimes implied by the processes are contradictory. Effusive volcanism on Mercury is believed to have produced flood basalts through dikes, the propagation of which is dependent on being able to open and fill vertical tensile cracks when horizontal stresses are small. On the contrary, thrust faults propagate when at least one horizontal stress is very large relative to the vertical compressive stress. We made sense of conflicting stress regimes through modeling with frictional faulting theory and Earth analogue work. Frictional faulting theory equations predict that the minimum and maximum principal stresses have a predictable relationship when thrust faulting is observed. The Griffith Criterion and Kirsch equations similarly predict a relationship between these stresses when tensile fractures are observed. Together, both sets of equations limit the range of stresses possible when dikes and thrusts are observed and permitted us to calculate deviatoric stresses for regions of Earth and Mercury. Deviatoric stress was applied to test a physical model for dike propagation distance in the horizontally compressive stress regime of the Columbia River Flood Basalt Province, an Earth analogue for Borealis Planitia, the northern smooth plains, of Mercury. By confirming that dike propagation distances from sources observed in the province can be generated with the physical model, we confidently apply the model to confirm that dikes on Mercury can propagate in a horizontally compressive stress regime and calculate the depth to the source for the plains materials. Results imply that dikes could travel from ∼89 km depth to bring material from deep within the lithosphere to the surface, and that Mercury’s lithosphere is mechanically layered, with only the uppermost layer being weak.
On the One-Point Model for the Productivity Evaluation in Jingbian Sector of Yan’an Gas Field
Authors: Er-hu Liu , Yang-yang Liu , Li-jun Gao , De-sheng Zhou , Xiong Liu , Jin-ze Xu
Published: December 2021

The productivity equation of a gas well is, in the final analysis, an expression that describes the relationship between the production of a gas well and its bottom-hole flowing pressure. There are two kinds of productivity equations in common use at present: binomial productivity equation and exponential productivity equation. Combined with the modified isochronal well test, the test data are interpreted, and it is found that the open flow rates calculated by the two productivity equations are basically the same when the pressure difference at the test point is large, and the deviation of the exponential productivity equation is large when the pressure difference at the test point is small. Using binomial productivity equation and modifying isochronous well test, we established the single-point deliverability formula for the Jingbian sector of the Yan’an gas field. The field experience formula and production data are used to verify it. Their average errors are 2.59% and 7.12%, respectively; and the coincidence rate of productivity evaluation is 90%. The one-point productivity formula established has high precision and is suitable for productivity analysis of gas wells in paleozoic reservoirs in the Jingbian sector of the Yan’an gas field. This paper provides insights into the one-point productivity evaluation and its future application in the gas field.