bluuebunny/crossref_metadata_2025 huggingface dataset:
Bioinformatics Prediction of miRNAs Targeting E6 and E7 Genes in Human Papillomavirus Types 16 and 18 in Cervical Cancer
Authors:   Department of Biotechnology and Molecular Medicine, School of Medicine, Arak University of Medical Sciences, Arak, Iran., Azimi Tahere , Bagheri Malihe ,   Department of Biotechnology and Molecular Medicine, School of Medicine, Arak University of Medical Sciences, Arak, Iran., Pariyan Mahdi ,   Department of Research and Development, Production and Research Complex, Pasteur Institute of Iran, Tehran, Iran., Khansarinejad Behzad ,   Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran., Zamani Ashraf ,   Department of Obstetrics and Gynecology, School of Medicine, Arak University of Medical Sciences, Arak, Iran., Mondanizadeh Mahdieh ,   Molecular and Medical Research Center, Arak University of Medical Sciences, Arak, Iran.
Published: November 2020

Background and Aim: Cervical Cancer (CC) is the third most common malignancy in the women, the main cause of which is human papillomavirus (HPV). Both E6 and E7 oncogenes of the virus play an important role in its tumorigenesis. Today, methods available for screening CC are not capable of detecting the disease at an early stage. Therefore, it is important to identify new biomarkers for early detection of this cancer. For this purpose, in the present study, miRNAs targeting the two oncogenes E6 and E7 of human papillomavirus (types 16 and 18) were studied in CC by bioinformatics. Methods & Materials: First, using the NCBI database, the E6 and E7 gene sequences were obtained for both human papillomavirus types 16 and 18. Then, using the miRBase and RNA22 bioinformatics databases, the most appropriate targeting miRNAs for these genes were selected. Ethical Considerations: This study was approved by Ethics Committee of Arak University of Medical Sciences. Results: Based on the P obtained from bioinformatics databases, miRNA including miR-92a-5p (P=7.51e-2), miR-195-3p (P=2.24e-1), miR-34a-5p (P=2.73e-1) and miR-155-5p (P=4.95e-2) were introduced for the two genes E6 and E7. Conclusion: Results from bioinformatics studies revealed that of the four miRNAs identified, miR-155-5p and miR-92a-5p are probably the targeting miRNAs specific for the E6 and E7 genes, respectively. Therefore, it seems that these miRNAs can be a suitable candidate for in vitro studies in CC patients.
Creating a Lip-reading Training Program and Examining its Effect on Speech Recognition in Men Aged 18-25 With Normal Hearing
Authors:   Department of Audiology, School of Rehabilitation, Hamadan University of Medical Sciences, Hamadan, Iran., Fazelian Seyede Faezeh , Mohammadzadeh Ali ,   Department of Audiology, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Zarinkub Homa ,   Department of Audiology, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Akbarzadeh Baghban Alireza ,   Department of Basic Sciences, School of Rehabilitation Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Published: November 2020

Background and Aim: Lip reading is extraction of speech data from the activity of the lower part of face, particularly jaws, lips, tongue, and teeth that is a natural skill in people with hearing loss. The main purpose of lip reading is to increase the independence of people with hearing loss. Looking at the speakers facial movements significantly increase the ability to understand the spoken words, particularly in the environments where noise is present. In fact this reflects the important role of visual signals. In current study we consider the effects of education on lip reading ability by planning and instructing a lip reading program in male subjects. Methods & Materials: Sara lip reading test 1 and 2 were used for the assessment of lip reading skills and for studying the effects of lip reading training on recognition of speech. This intervention as a semi-experimental study, was conducted on 27 male students, selected by available sampling. For data analysis, statistical analysis of variance with repeated measurements and Mcnemar was used. Ethical Considerations: This research with the code IR.SBMU.REC.1394.144 has been approved by the ethics committee of Shahid Beheshti University of Medical Sciences. Results: There were significant differences between Sara lip reading test 1 scores in 2 positions (P=0.000).Lip reading test scores also showed significant differences in Sara lip reading test 2 in 2 positions (P=0.000). Also between the scores of Consonant-vowel, consonant-vowel syllables, in the position before teaching lip-reading and then ,was significant difference (P<0.05). Conclusion: The findings of this study showed that instructing lip reading has a positive effect on lip-reading ability in people.
HORISON HARAPAN PEMBACA TERHADAP NOVEL API TAUHID KARYA HABIBURRAHMAN EL SHIRAZY
Authors: Puspa Belia , Kamidjan Kamidjan , Sari Raras Hafidha
Published: November 2020

Penelitian ini berisi diskusi tentang cakrawala harapan lima pembaca dari siswa di pondok pesantren Darul Falah V Cukir terhadap novel Api Tauhid karya Habiburrahman El Shirazy. Novel Api Tauhid adalah novel yang menceritakan sejarah perjuangan ulama besar, yaitu Said Nursi dalam menyebarkan Islam di Turki Ottoman dan juga novel roman yang menceritakan perjuangan cinta Fahmi dalam menjaga hubungannya dengan Nuzula. Fokus penelitian ini adalah harapan para siswa sebagai pembaca dalam periode waktu tertentu pada novel Api Tauhid. Penelitian ini menggunakan teori penerimaan sinkron dan metode yang digunakan dalam penelitian ini adalah kualitatif. Analisis data dalam penelitian ini menggunakan analisis analitik dengan beberapa tahapan, yaitu pemilihan data, pengkodean data, interpretasi data dan penarikan kesimpulan.
ANALISIS KEBAHASAAN K.H. AHMAD MUWAFIQ DALAM CERAMAH “REKONSILIASI PERAN PEMUDA DALAM BINGKAI KEBANGSAAN”
Authors: Anjarsari Marianita
Published: November 2020

In general, language as a community communication tool is usually used by certain groups of people who belong to the language community. Language communities are those who feel that they own and use the same language. Community members have different backgrounds and social status. For example there are differences in employment, education, and so on. As a result of differences that occur variations in language. This study aims to describe the form of 1) variations of idiolects, 2) variations of dialects, 3) variations of registers, and, 3) variations of code switching made by K.H. Ahmad Muwafid in the Reconciliation Lecture on the Role of Youth in the National Frame at Karangdurin Islamic Boarding School, Madura. This research uses descriptive qualitative method, with data collection techniques in the form of SBLC techniques and note taking techniques. The data validity technique uses data triangulation. The results showed that K.H. Ahmad Muwafiq uses idiolastic variations, namely 1) the use of regional languages such as Javanese or Madurese, and Betawi, and there is a mixture of Arabic, 2) the use of Javanese words, 3) the use of hyperbole and metonemical language styles, and 4) pronunciation of existing words in Arabic. K.H. Ahmad Muwafiq uses East Javanese, Madurese, or Sundanese dialects. K.H. Ahmad Muwafiq uses the list of priests. K.H. Ahmad Muwafiq did the code switching. The benefits of this research are expected to be insight into various languages in the world of preaching.
Universale o particolare?
Authors: Pietrzak-Thébault Joanna
Published: November 2020

La Polonia nei tempi del Rinascimento si situava su un territorio ben
diverso rispetto a quello di oggi: molto più esteso e rivolto molto di più
verso l’oriente. Un territorio polonizzato, a volte perfino trattato come
colonizzato (secondo un punto di vista), dove pochi centri culturali,
anche se alcuni di un grande rilievo, furono sparsi attraverso un vasto
territorio. Essi non rispecchiavano la realtà delle etnie presenti entro i
confini della Repubblica Nobiliare ma influivano fortemente il mescolarsi
ulteriore e lo sviluppo dei paradigmi culturali del vasto paese. Tracciare
la storia del pensiero umanistico nonché quello della diffusione
della filosofia e della retorica pare facilitato da un panorama delle istituzioni
d’insegnamento, a cominciare dall’Accademia di Cracovia, la
futura Università Jagellonica, fondata nel 1364. Il centro accademico
concorreva con la corte reale che continuava a costituire un luogo particolarmente
vivace della vita intellettuale. L’influsso degli studi intensi
dello Stagirita si facevano sentire perfino nel centro di studi rabbinici
nella città di Kazimierz nelle vicinanze del castello e dell’ateneo. Se
l’insegnamento della filosofia nel corso del Cinquecento attraversa fasi
diverse, per chiudersi finalmente verso la fine del secolo in un nominalismo
eclettico e rigido, appare comunque una nuova forma dell’ateneo
ideata su modello del Collegio Regio parigino, apparentemente capace
di rinnovare non soltanto l’insegnamento ma anche la ricerca filosofica.
L’Accademia di Jan Zamoysk situata nella sua città di Zamość ne costituisce,
soprattutto durante il primo Seicento, il centro più vivace. Una
svolta verso l’insegnamento pragmatico, al servizio degli affari pubblici
è ormai visibile. Le stesse tendenze prevalgono nei programmi di collegi
accademici di stampo protestante, situati soprattutto nella Pomerania
e nelle città baltiche, anche se le basi ideologiche e religiose del loro
insegnamento furono ben diverse. Finalmente saranno i collegi gesuiti,
a partire perfino dagli anni sessanta del Cinquecento, seminati in tutto
il paese, a diffondere (soprattutto presso i giovani nobili cattolici, ma
anche allievi venuti da altri ambienti, siccome l’insegnamento fu gratuito
e aperto a tutti coloro che volevano studiare) una conoscenza del
latino, della retorica, della cultura antica al servizio di un’identità particolare,
radicata nella tradizione antica, volta però al presente – verso
il servizio pubblico e quello cittadino.
Etica e politica di Lorenzo il Magnifico
Authors: Secchi Tarugi Luisa
Published: November 2020

Lorenzo de’ Medici, uomo di profonda fede, data la mirabile educazione
ricevuta in famiglia, accettò il governo della città dopo la morte
del padre, Piero il Gottoso, come dovere, sentendone il peso, data la
sua giovane età di 21 anni, secondo quanto lui stesso dice “mal volentieri
accettai”. In tutta la sua vita, non molto lunga, privilegiò come fine
il conseguimento del bene comune e non il proprio interesse. Attento
anche alle situazioni dei meno fortunati, come il popolo fiorentino e
i contadini del Mugello, si rivelò un abile politico che riuscì ad equilibrare
la politica dei vari staterelli italiani, ma non dimenticò mai quale
fosse il traguardo vero della vita dell’uomo e cioè guardare verso Dio
staccandosi dalle ambizioni della vita terrena. Soprattutto raccomandò
ai figli di saper governare diventando esempio “perché il signore deve
essere servo de’ suoi servi” come scrive nella Sacra rappresentazione di
Giovanni e Paolo messa in scena il 17 febbraio 1491 nella Compagnia
del Vangelista.
Prevenção da COVID-19? Efeitos adversos da ivermectina em posologia inapropriada
Authors: Pereira Fernanda Cândido , Montenegro Mariana Lima , Barbéro Bruna Benedetti , Parente Débora Barbosa da Silva , Arantes Isabela Maria , Zoobi João Luís de Arruda Pereira , Frota Mateus Gomes , Santos Rafael Lucas Simões dos , Cunha Rafaela de Albuquerque , Lima Andreza Brandão Theophilo
Published: November 2020

Objetivo: Identificar os malefícios e a toxicidade do uso da ivermectina em doses maiores do que as doses terapêuticas, bem como correlacionar seu uso, em doses mais elevadas do que as terapêuticas convencionais, como forma de prevenção para a COVID-19. Métodos: Trata-se de uma revisão bibliográfica do tipo integrativa, com abordagem qualitativa e natureza aplicada, objetivando a descrição da análise de dados coletados sobre o uso inapropriado da Ivermectina no tratamento da COVID-19 e seus efeitos adversos. Este trabalho foi desenvolvido através de pesquisa bibliográfica na base de dados da Biblioteca Virtual de Saúde (BVS) e do PubMed, na qual foram priorizados artigos/estudos publicados nos últimos 5 anos, que retratassem temática convergente aos objetivos da pesquisa, anexados nos idiomas: português, inglês e espanhol. Desse modo, foram selecionados 17 artigos para leitura, os quais constituem esta revisão de literatura. Resultados: 25,52% dos estudos selecionados abordaram os principais efeitos adversos advindos da terapia convencional com Ivermectina, os quais, em sua maioria, são sintomas gástricos e neurológicos leves, como náuseas, vômitos, cefaleia e vertigens. Dito isso, observou-se também que em 35,29% dos estudos analisados indicam o sucesso da Ivermectina em reduzir o material genético viral do SARS-CoV-2, in vitro. Entretanto, ao se considerar o organismo humano a dose utilizada nos estudos in vitro torna-se inviável, pois proporcionalmente seria necessária uma dose de 1000 a 1200mg, logo tal dose aplicada em humanos poderia levar a intoxicação, cujo sintomas são ataxia e convulsões. Dentre os demais sintomas correlacionados ao tratamento com Ivermectina também observou-se a presença de bradipneia, tremores, ptose, redução de atividade e midríase, estes em doses acima da convencional. Conclusão: Diante dos estudos sobre a eficácia da Ivermectina como prevenção e resolução da COVID-19 e dos estudos que relatam sua toxicidade e malefícios em altas doses, pode-se concluir que ainda não há confirmação de eficácia do seu uso em humanos para tratamento e prevenção antiviral.
Dimensionamento de profissionais de enfermagem nos serviços hospitalares com atendimento obstétrico
Authors: Lima Thaís Bebiana de Almeida , Souza Karinne Ferreira de , Almeida Eder Júlio Rocha de , Lima Patrícia Oliveira , Almeida Herlon Fernandes de
Published: November 2020

As questões que envolvem a gestão em saúde estão cada vez mais evidenciadas no cotidiano dos profissionais da área. Como gestor de saúde, o enfermeiro necessita aplicar instrumentos gerenciais que possibilitem alcançar os objetivos propostos, para que a prática do cuidado seja efetiva e segura. Uma dessas ferramentas é o dimensionamento de pessoal na enfermagem. O objetivo desse estudo é identificar os parâmetros e instrumentos utilizados para realizar o dimensionamento das equipes de enfermagem em serviços de saúde hospitalares com atendimento obstétrico preconizado pelas recomendações, portarias e resoluções vigentes. Trata-se de uma pesquisa de revisão integrativa da literatura, de cunho qualitativo, utilizando resoluções e portarias do Ministério da Saúde e Conselho Federal de Enfermagem em vigor para direcionamento dos parâmetros de pessoal de enfermagem nesses serviços. Pode-se observar que para cada área de atuação de enfermagem no serviço de saúde foram identificadas portarias e resoluções que subsidiam gestores para a utilização de ferramentas de dimensionamento de pessoal de enfermagem, sendo a Resolução COFEN-543/2017 possível ser aplicada em todas as unidades da instituição onde há atuação da enfermagem. Nos cálculos devem ser considerados características dos serviços de saúde e garantia de requisitos mínimos estabelecidos pelo Ministério da Saúde. Conclui-se que os parâmetros e instrumentos apresentados, fornecem ferramentas para direcionar prestação de serviço seguro para os clientes das instituições, cabendo ao gestor a aplicação dos modelos de dimensionamento de pessoal de enfermagem rotineiramente correlacionando à carga de trabalho e indicadores de qualidade para a gestão dos serviços de saúde e garantia da sustentabilidade.
Modalidades de terapias combinadas na abordagem da Síndrome dos Ovários Policísticos: Uma revisão de literatura
Authors: Vasconcelos Isys Holanda Albuquerque de , Andrade Renata Nogueira , Albuquerque Bárbara Prado De , Cid Bárbara Timbó , Souza Beatrice Ponte , Mascarenhas Eduarda Bandeira , Mendes Felipe Pinheiro , Soares Iane Taumaturgo Dias , Machado Lia Portella , Queiroz Rodrigo Marques
Published: November 2020

Introdução: O objetivo desse artigo, é avaliar a eficácia de recursos terapêuticos usualmente utilizados e confrontar com estudos que os associam a outras modalidades de terapias. Observando se há benefício que justifique a indicação de modalidades de terapias combinadas para as pacientes, visando otimização do tratamento e aumento na qualidade de vida. Método: Trata-se de uma revisão bibliográfica do tipo integrativa de caráter retrospectivo com abordagem qualitativa, elucidando a descrição e a aplicação dos estudos. Tal pesquisa ocorreu nos meses de Agosto e Setembro de 2020 por meio da base de dados PubMed usando as seguintes palavras-chave: “Combined modality therapy” e “polycystic Ovary syndrome”. Resultando em 22 artigos, avaliados pelo método de revisão integrativa, que compreenderam os objetivos do presente estudo. Resultados: Foram analisados 21 estudos, dentre eles a fração mais significativa correspondeu ao dos ensaios clínicos randomizados, 66,67% (n=14). Desses, 64,28% (n=9) foram sobre terapias alternativas. 24,42% (n=3), abordaram medicamentos orais; e 14,28% (n=2) trouxeram como intervenção mudança de estilo de vida (MEV). Os demais se dividiram entre estudos de caso- controle, 23,80% (n=5), e coorte, 9,52% (n=2), no qual um deles avaliou uma intervenção cirúrgica. Conclusão: Os estudos avaliados envolvendo MEV, medicações orais, terapias alternativas e procedimento cirúrgico evidenciaram que, de maneira geral, o tratamento combinado realizado com essas abordagens emerge como opção segura que acarreta benefícios adicionais quando comparados à monoterapia, sobretudo em relação à perda de peso, ao ajuste das medidas corporais, à regulação hormonal, à infertilidade e ao controle do hirsutismo. Contudo, algumas das terapêuticas analisadas mantêm desfechos muito semelhantes tanto em monoterapia como em terapia combinada, sendo necessário, portanto, individualização da necessidade, avaliação do custo-benefício e mensuração do real impacto de uma terapia adicional na qualidade de vida da paciente para definição do tratamento que será utilizado.
Double Approach (Laparoscopy and Hysteroscopy) Repair of Istmochele (Niche)
Authors: Situmorang Herbert , Putri Ribkhi A. , Pramayadi Cepi T. , Kurniawan Riyan H. , Priangga Muhammad D. , Gunardi Eka R.
Published: November 2020

Objectives: Reported a case demonstrate the double approach repair of niche treatment through the hysteroscopy and laparoscopy technique.Methods: Case report. We reported a case starting from the patient admission untill 3 months postoperative condition.Case: A 33 years old woman came with abnormal uterine bleeding, already got medication and combine oral contraception pill, but the bleeding never stopped. We found a cavity (niche) filled by menstrual blood with thin lower uterine segment (just serous layer) from transvaginal ultrasound. We did hysteroscopy and laparoscopy approach. We illuminated the niche by hysteroscopy, then resected it by laparoscopy. Patient had a day hospital admission and no symptoms anymore after the procedure.Conclusion: Many treatment methods have been described for repair of niche with varies effectivities. Double approach (hysteroscopy and laparoscopy) technique was a minimal access, but optimal approach of niche resection with up to 100% effectivity.Keywords: abnormal uterine bleeding, caesarean scar defect, hysteroscopy, istmochele laparoscopy, niche

 

Abstrak

Tujuan: Melaporkan sebuah kasus yang menggambarkan pendekatan ganda dalam memperbaiki niche dengan histeroskopi dan laparoskopi.Metode: Laporan kasus. Kami melaporkan sebuah kasus dimulai dari pasien masuk sampai dengan 3 bulan pascaoperasi.Kasus: Perempuan 33 tahun datang dengan perdarahan uterus abnormal, telah diberikan terapi obat dan pil kombinasi, namun perdarahan tidak berhenti. Dari ultrasonografi ditemukan rongga berisi darah menstrusasi dengan segmen bawah uterus yang tipis (hanya lapisan serosa). Kami melakukan pendekatan histeroskopi dan laparoskopi. Dilakukan iluminasi dengan histeroskopi, kemudian reseksi dengan laparoskopi. Perawatan pasien di rumah sakit selama satu hari, dan tidak terdapat keluhan pada pasien setelah tindakan.Kesimpulan: Terdapat banyak metode dalam tata laksana niche dengan efektivitas yang beragam. Pendekatan ganda dengan histeroskopi dan laparoskopi merupakan tehnik dengan akses minimal namun hasil optimal, dengan efektivitas hingga 100%.Kata Kunci: perdarahan uterus abnormal, defek skar sesar, histeroskopi, istmpchele, laparoskopi, niche
Assessment of the Quality of Internet-Based Health Information in the Indonesian Language about Polycystic Ovarian Syndrome
Authors: Hestiantoro Andon , Pamungkas Danang T.
Published: November 2020

Objectives: To investigate health information quality about PCOS on the internet in Indonesian language.Methods: Top website from two separate search engines (Google and Bing) was collected using the keyword of “sindrom ovarium polikistik” (polycystic ovarian syndrome). Analysis of health information quality on those websites was performed.Results: Sixty-nine websites were included for analysis. The majority of those websites have good information quality in terms of content accuracy and website credibility. There was no difference in quality between the two search engines. The website was found at the top two pages in each search engine to have better quality than the later pages (p=0.02). The educational website had better quality (p=0.05). The website made by healthcare organizations had better quality (p=0.04). The non-commercial website had better information quality (p=0.01).Conclusion: Criteria affecting health information quality on the internet were as follows: found at the top two pages on a search engine; educational website; made by healthcare organization; and non-commercial purpose.Keywords: health information quality, Indonesian language, internet-based, polycystic ovarian syndrome

Abstrak

Tujuan: Untuk melakukan kajian kualitas informasi kesehatan tentang PCOS di internet dalam Bahasa Indonesia.Metode: Situs web teratas dari dua mesin pencari terpisah (Google dan Bing) dikumpulkan dengan menggunakan kata kunci “sindrom ovarium polikistik”. Analisis kualitas informasi kesehatan pada situs-situs tersebut telah dilakukan.Hasil: Enam puluh sembilan situs web dimasukkan untuk analisis. Mayoritas situs web tersebut memiliki kualitas informasi yang baik dalam hal akurasi konten dan kredibilitas situs web. Tidak ada perbedaan kualitas antara kedua mesin pencari tersebut. Situs web ini ditemukan pada dua halaman teratas di setiap mesin pencari memiliki kualitas yang lebih baik daripada halaman-halaman selanjutnya (p = 0,02). Kualitas situs web berbasis pendidikan menunjukkan hasil lebih baik (p = 0,05). Kualitas website yang dibuat oleh organisasi kesehatan menunjukkan hasil lebih baik (p = 0,04). Situs web non-komersial memiliki kualitas informasi yang lebih baik (p = 0,01).Kesimpulan: Kriteria yang mempengaruhi kualitas informasi kesehatan di internet adalah sebagai berikut: ditemukan pada dua halaman teratas pada mesin pencari; situs web berbasis pendidikan; dibuat oleh organisasi kesehatan; dan tujuan non-komersial.Kata kunci : bahasa indonesia, berbasis internet, kualitas informasi kesehatan, sindrom ovarium polikistik.
Risk of Malignancy Index 4 (RMI4) and Risk of Malignancy Index 3 (RMI3) as Diagnostic Tests for Adnexal Tumor
Authors: Nurseta Tatit , Irwanto Yahya , Prasetyorini Nugrahanti , Rahardjo Bambang , Subage I Wayan
Published: November 2020

Objective: Comparing scoring with RMI3 and RMI4 in establishing the diagnosis of adnexal tumour in RSUD Dr. Saiful Anwar Malang.Methods: Prospective cohort study with samples of all patients suspected of having an adnexal tumour diagnosed in gynecology policlinic using gynecological oncology policlinic medical records at RSUD Dr. Saiful Anwar in the form of age, demographics, menopause status, Ca125, ultrasound results.Results: Between the RMI3 results and the results of histopathology, a contingency coeffi cient of 0.596 was obtained with a p-value of 0.000015 (p <0.05), with a PPV of 83%, an NPV of 91%. Between the RMI4 results and the histopathology results, a contingency coeffi cient of 0.657 with a p-value of 0.0000004 (p <0.05) was obtained, with a PPV of 92%, NPV of 95%. On the ROC curve, the area of the predicted results using the RMI4 score is higher than the RMI3 score.Conclusions: Using the RMI4 score results in more accurate predictions than the RMI3 score in detecting adnexal tumour malignancies.Keywords: adnexal tumours, diagnostic tests, ovarian tumours, risk of malignancy index, ultrasound. Abstrak

Tujuan: Membandingkan Skoring RMI3 dan RMI4 dalam menegakkan diagnosis tumor adneksa di RSUD dr. Saiful Anwar Malang.Metode: penelitian kohort prospective dengan sampel semua pasien yang dicurigai menderita tumor adneksa yang didiagnosis di poli Ginekologi menggunakan data rekam medis poli Ginekologi Onkologi RSUD dr. Saiful Anwar berupa usia, demografi , status menopause, Ca125, hasil USG.Hasil: Antara hasil RMI3 dengan hasil hispatologi, didapatkan koefi sien kontingensi sebesar 0,596 dengan p-value 0,000015 (p<0,05), dengan PPV 83%, NPV 91%. Antara hasil RMI4 dengan hasil histopatologi, didapatkan koefisien kontingensi sebesar 0,657 dengan p-value 0,0000004 (p<0,05), dengan PPV 92%, NPV 95%. Pada kurva ROC, luas area hasil prediksi dengan menggunakan skor RMI4 lebih tinggi daripada skor RMI3.Kesimpulan: Menggunakan skor RMI4 menghasilkan prediksi yang lebih tepat daripada skor RMI3 dalam mendeteksi keganasan tumor adneksa.Kata kunci: risk of malignancy index, tumor adneksa, tumor ovarium, uji diagnostik, USG.
Efficacy of Trichloroacetic Acid (TCA) Compared to Cryotherapy in Treating Patients with Positive VIA Result
Authors: Herdhana Suwartono , Andrijono
Published: November 2020

Objective: To investigate the effectiveness TCA 85% compared to cryotherapy to treat patients with positive IVA result.Method: This is a non-inferiority randomized controlled trial study. Patients with positive VIA result referred to Jatinegara Primary Health Center were included in this study. Eligible samples were then treated with either TCA 85% or cryotherapy. The treatment was determined using a random block sampling method. Samples were then followed up 3 months after treatment in order to determine VIA result conversion.Result: Thirty-six patients were treated with TCA 85% and 36 others were treated with cryotherapy. 35 (97,2%) patients treated with TCA 85% converted to negative VIA, whereas all of the patients that were treated with cryotherapy converted to negative VIA. Bivariate analysis fisher’s exact test was then conducted with a result P-value of 1.00 (p > 0,05).Conclusion: There was no statistically significant difference of result between TCA 85% and cryotherapy for treating patients with positive VIA result.Keywords: cervical cancer, cryotherapy, TCA 85%, VIA test.

Abstrak

Tujuan: Mengetahui efikasi TCA 85% pada tatalaksana IVA positif dibandingkan dengan krioterapiMetode: Penelitian ini merupakan penelitian randomized control trial menggunakan metode non-inferiority study. Subyek penelitian ini merupakan pasien dengan hasil IVA positif yang dirujuk ke Puskesmas Kecamatan Jatinegara, Jakarta Timur. Tatalaksana yang diberikan ditentukan menggunakan metode random block sampling. Subyek diikuti selama 3 bulan setelah tindakan untuk menentukan hasil konversi pemeriksaan IVA.Hasil: Sbenyak 36 subjek diterapi dengan TCA 85% dan 36 lainnya diterapi dengan krioterapi. Sebanyak 35 (97,2%) pasien yang ditatalaksana dengan TCA 85% mengalami konversi menjadi IVA negatif pada follow-up bulan ke-3, sedangkan seluruh pasien yang ditatalaksana dengan krioterapi menjadi konversi menjadi IVA negatif. Dilakukan analisis bivariat fisher’s exact test dan didapatkan nilai p sebesar 1,00 (p>0,05).Kesimpulan:Tidak ada perbedaan bermakna dari efikasi penggunaan TCA 85 % dibandingkan dengan krioterapi pada terapi IVA positif.Kata kunci: kanker serviks, krioterapi, pemeriksaan IVA, TCA 85%.
Management control systems in the knowledge economy: Assessing the role of intellectual capital in
Authors: Ricci Federica , Scafarto Vincenzo , Ferri Salvatore , Riso Teresa
Published: November 2020

The purpose of this paper is to show that intellectual capital (IC) efficiency as measured by the value added intellectual coefficient (VAIC) and its individual components may function as key performance indicators for use in management control and external reporting to capital market participants. We incorporate the VAIC within the Ohlson model (OM), a widely used model for equity valuation, which relates a firm's market value to the book value of equity and net earnings, and allows to include any other information that may affect the market assess-ment of firm value. We then estimate the modified OM on a panel sample of firms continuously listed on the Italian Stock exchange from 2011 to 2017 using a fixed effect (FE) specification. Empirical results indicate that IC efficiency contributes along with the traditional accounting metrics included in the OM to explain the stock market performance of sample firms. This paper suggests that the VAIC and the individual measures of IC efficiency may usefully complement traditional accounting measures of performance.
A hazai rövid ellátási láncok (REL) probléma-fa struktúrája, fejlesztési lehetőségének cél- és eszközrendszere
Authors: Vincze Judit , Antal Sándor
Published: November 2020

Tanulmányunkban a rövid ellátási láncokat (REL), mint a kis – és családi gazdaságok számára is elérhető innovációs lehetőségeket vizsgáltuk. A kutatások egyrészt a REL legközvetlenebb csatornáira, a helyi- és termelői piacokra, másrészt a REL-ok magasabb működési formáját megvalósító, Közösség által Támogatott Mezőgazdaság (KTM) szervezeteire terjedtek ki. A tanulmány fókuszában azok az ökonómiai -, jogi -, (agrár)üzemtani, valamint marketing - és logisztikai jellemzők álltak, melyek jelenleg körbeveszik a működő REL értékesítési csatornáit, helyzetüknél fogva vagy segítik, vagy gátolják a RELok fejlődését és terjedését. A REL-ok, és bennük a KTM szervezetek, a helyi termékekkel kapcsolatos fogyasztói elvárásokra, valamint termelői lehetőségekre nyújtanak olyan megoldási formát és szervezeti (gazdasági) keretet, melynek hatásai nem csak az élelmiszerellátás területén, hanem a fenntarthatóság (természeti környezet, helyi gazdaság, szociális és társadalmi környezet, stb.), illetve a vidékfejlesztés területén is pozitívan jelentkeznek. Hazai viszonylatban a Vidékfejlesztési Program (2014-2020) keretein belül kapott helyet a Rövid Ellátási Lánc Tematikus Alprogram, melynek elsődleges célja a helyi termelők támogatása, a helyi termékek értékesítésének elősegítése. A program indulásának ellenére, a kutatások azt mutatják, hogy a REL-ok által kínált lehetőségek jelenleg kihasználatlanok. Tanulmányunkban ennek a kihasználatlanságnak az okait vizsgáltuk, valamint a kihasználtság javítását elősegítő (egy lehetséges) eszközrendszert dolgoztunk ki. A kutatás célkitűzései egyrészt a jelenlegi problémák feltárására, másrészt a jövőre vonatkozó perspektivikus fejlesztési lehetőségekre terjedtek ki.
Estimation of Surface Runoff to Support Flood Hazards Early Warning Using Landsat 8 OLI Imagery
Authors: Ipung  , Erlangga Oita Mulazahwa , Andam Dewi Nastasya , Pandhadha Evan Ardi Kristya , Widyatmanti Wirastuti
Published: November 2020

This study aims to determine the estimated surface runoff in the Diro sub-watershed in Kulon Progo Regency using OLI Landsat 8 imagery. Landsat images are used to determine the type of land cover which is one of the watershed characteristics. The method used to determine the surface runoff coefficient value in the Diro sub-watershed was using the cook’s method. The parameters used to determine the value of surface runoff include vegetation density, flow density, soil type and slope. The results showed that the sub-watershed Diro has a surface coefficient value of 0.7999 and is in the high category.
Total Suspended Solid (TSS) Estimation in Lake Tempe, South Sulawesi Using Sentinel-2B Imagery
Authors: Pandhadha Evan A K , Aunurrahim Ab ghy , Ayudyanti A G , Huda Miftahul , Sabrina N F , Anindya S
Published: November 2020

Lake Tempe is located in three districts, namely Wajo, Sidenreng Rapang, and Sopeng, South Sulawesi. The water quality in Lake Tempe needs to be considered both the quality and the quantity of the water. Total Suspended Solid (TSS) is one of the calculations and analysis of air quality. The large of TSS distribution can overcome the effects of sedimentation thereby reducing the need for lakes in saving water. TSS distribution at Lake Tempe can be accessed through Sentinel2B imagery with acquisition time 10 April 2019 and spatial resolution of 10 meters. The algorithm used is NSMI (Normalized Suspended Material Index) algorithm then the results are compared with TSS measurements result in the field. The time of the study was conducted in April 2019 at Lake Tempe, South Sulawesi. The result from samples showed various TSS value which is in the range of 65 mg/L to 203 mg/L with R2of 0.1194 and standard deviation of 8.7106. High TSS value on the banks of the North lakes also had high sedimentation. Low TSS value are in the middle of the lake with small sedimentation and deeper lake
Maternal mortality: when the babies lose their mothers due to premature death
Authors: Moreira da Silva Anne Beatriz , Baraúna da Silva Alessandra , Catique Barbosa Christian , Reína Lozano Vieira Damara , da Silva Tavares Dayane , Duarte Prestes Ellen Juliany , da Silva Souza Giovanna , Lopes Mendonça Mayara Greyce , Nunes Figueiredo Silvana
Published: November 2020

Objective: Identify in the published articles the main factors that cause premature maternal mortality in pregnant women or when they give birth. Method: This is an exploratory descriptive study in the search for scientific publications on causes of maternal death. The study took place from the beginning of August 2019 to September 2020. Platforms such as SCIELO, LILACS BVS were used and the selection criteria for the research bibliography were the eligibility and ineligibility of articles, theses and monographs. Thus, 20 studies on the subject “Maternal mortality, when the babies lose their mothers due to premature death” were selected for analysis. Results: Maternal death in Brazil is directly linked to the living conditions of the Brazilian female population, mainly to socioeconomic factors or lack of commitment to basic social assistance and health prevention.
Oito anos de PNAD Contínua (2012-2019): regularidades para desigualdade de renda trimestral e mercado de trabalho
Authors: Pitombo Leite Fabrício
Published: November 2020

Esta nota reavalia a evolução da desigualdade de renda no Brasil entre 2012 e 2019, conforme representada pelo índice de Gini para o rendimento domiciliar per capita efetivo de todos os trabalhos computado a partir dos microdados trimestrais da PNAD Contínua. Regularidades com relação ao comportamento do mercado de trabalho são delineadas, bem como a observância de dois períodos bem demarcados para queda e ascensão da desigualdade no Brasil recente.
Efficient Rule Generation for Associative Classification
Authors: Thanajiranthorn Chartwut , Songram Panida
Published: November 2020

Associative classification (AC) is a mining technique that integrates classification and association rule mining to perform classification on unseen data instances. AC is one of the effective classification techniques that applies the generated rules to perform classification. In particular, the number of frequent ruleitems generated by AC is inherently designated by the degree of certain minimum supports. A low minimum support can potentially generate a large set of ruleitems. This can be one of the major drawbacks of AC when some of the ruleitems are not used in the classification stage, and thus (to reduce the rule-mapping time), they are required to be removed from the set. This pruning process can be a computational burden and massively consumes memory resources. In this paper, a new AC algorithm is proposed to directly discover a compact number of efficient rules for classification without the pruning process. A vertical data representation technique is implemented to avoid redundant rule generation and to reduce time used in the mining process. The experimental results show that the proposed algorithm archives in terms of accuracy a number of generated ruleitems, classifier building time, and memory consumption, especially when compared to the well-known algorithms, Classification-based Association (CBA), Classification based on Multiple Association Rules (CMAR), and Fast Associative Classification Algorithm (FACA).
Biomass Characteristics and Energy Yields of Tobacco (Nicotiana tabacum L.) Cultivated in Eastern Poland
Authors: Berbeć Adam Kleofas , Matyka Mariusz
Published: November 2020

The present pilot study examined the potential of tobacco (Nicotiana tabacum L.) as an energy source. The fresh matter of whole tobacco plants, the yield of dry matter of stems and leaves, as well as the higher heating value and methane production potential from tobacco biomass were determined. The yield of tobacco leaves was on average 4.69 Mg ha−1 (dry matter) and 76.90 GJ ha−1 yr−1 (biomass energy yield). Tobacco stems yielded on average 8.55 Mg ha−1 and 150.69 GJ ha−1 yr−1, while yields of whole tobacco crops were (on average) 13.24 Mg ha−1 and 227.59 GJ ha−1 yr−1. Methane potential of tobacco plants was (on average) 248 Nm3 Mg−1 VS (volatile solids). The tobacco plants tested in the study could be used as energy crops as their dry matter and energy yields are similar to those of the most popular energy crops being currently used in biomass production in Poland and the European Union. Nevertheless, further studies to choose the Nicotiana species and varieties most suitable for energy production and to assess the cost-effectiveness of tobacco biomass production are needed.
The Effect of Foliar and Soil Application of Flufenacet and Prosulfocarb on Italian Ryegrass (Lolium multiflorum L.) Control
Authors: Andreasen Christian , Høgh Kasper Lund , Jensen Signe Marie
Published: November 2020

Italian ryegrass (Lolium multiflorum Lam.) can be a troublesome weed that may causes high yield losses to several crops. Ryegrass resistance to the typically used acetolactate synthase (ALS) and acetyl-CoA carboxylase (ACCase) inhibiting herbicides complicates the control. As an alternative, we evaluated and compared the effects of two soil-acting herbicides, flufenacet and prosulfocarb, on susceptible L. multiflorum. The herbicides were applied in two doses in three different methods of applications: (1) soil and foliar application (2) foliar application, and (3) soil application only. Two greenhouse experiments separated in time showed that both herbicides reduced root and foliar biomass significantly as compared to the nontreated plants. In experiment 1, both herbicides resulted in lower efficacy when they only were applied to the leaves compared to the nontreated plants. Especially the foliar effect of flufenacet was small. The highest dose of prosulfocarb (4200 g ai ha−1) reduced the fresh foliar weight by 61% in experiment 1 and by 95% in experiment 2. The lowest dose of prosulfocarb (2100 g ai ha−1) reduced the weights by 73% (experiment 1) and 98% (experiment 2), respectively. For both herbicides the soil and foliar application applied postemergence were effective in reducing growth of L. multiflorum significantly in both experiments. Foliar application showed inconsistent results, showing that soil absorption plays an important role on herbicide efficacy even when the herbicides are applied postemergence. Postemergence application of prosulfocarb and flufenacet were effective to reduce L. multiflorum growth having apparently good root and leaf absorption.
Interactive Effects of Elevated Ozone and Temperature on Growth and Yield of Soybean (Glycine max (L.) Merr.) under Field Conditions
Authors: Burkey Kent , Tisdale Ripley , Zobel Richard , Ray Samuel , Pursley Walter
Published: November 2020

Elevated ozone and rising temperature are both factors in climate change, but they are difficult to study in combination due to exposure system requirements. We developed and deployed an air exclusion exposure system to treat soybean (Glycine max (L.) Merr.) cultivar “Jake” with season-long combinations of sub-ambient ozone (18 ppb, 12 h mean), elevated ozone (66 ppb, 12 h mean), and elevated temperature (+3.5 °C daytime, +2.4 °C nighttime) in irrigated field plots. Warming caused a shift in biomass partitioning from reproductive tissues into stems and petioles at mid-season that resulted in a significant 25% reduction in final seed yield and a significant reduction in harvest index. The elevated ozone treatment delayed mid-season biomass production, and final seed yield was reduced by a non-significant 2%. However, there were significant underlying effects of elevated ozone on seed production. The non-significant impact of ozone on seed yield of cultivar “Jake” resulted from significant increases in pod number (+16%) and seed number (+18%) that were offset by a significant reduction in seed size (−16%). No evidence of significant warming–ozone interactions was found in biomass or seed yield responses. In general, significant impacts of the individual warming or ozone treatments were found to be additive.
Seasonal Herbaceous Structure and Biomass Production Response to Rainfall Reduction and Resting Period in the Semi-Arid Grassland Area of South Africa
Authors: Magandana Thabo Patrick , Hassen Abubeker , Tesfamariam Eyob Habte
Published: November 2020

Reduction in rainfall is amongst the major climate change manifestation phenomena, and will have a significant impact on grassland ecosystems. A split plot experimental design was used to investigate the interactive effect of rainfall reduction and resting period (RP) (70 and 90 days) on herbaceous biomass production and rainwater use efficiency in semi-arid grasslands of South Africa. Different levels of rainfall reduction (RD) were setup as main plot treatments while resting periods were set as sub-plot treatments. Four 0.5 m × 0.5 m quadrats were harvested in spring, summer and autumn of 2016/17 and 2017/18 from each sub-plot to determine herbaceous species structure, aboveground biomass production and rainwater use efficiency (RUE). Grasses were most affected by rainfall reduction than forbs at the 30% and 60% RD levels. In contrast, the forbs were more affected at 15% RD while the grasses showed resilience up to 15% reduction in rainfall. The RUE was higher at 30% RD and 70 days RP in almost all three seasons, except in spring 2016/17. Our results show that herbaceous above ground biomass showed resilience up to 15% reduction but were affected more as the rainfall reduction exceeded 30%. The future predicted reduction in rainfall may result in domination of forbs and increaser grass species in the grassland.
Optimizing Induction Heating of WNiCo Billets Processed via Intensive Plastic Deformation
Authors: Kunčická Lenka , Macháčková Adéla , Petrmichl Rudolf , Klečková Zuzana , Marek Martin
Published: November 2020

The aim of the work is to optimize the induction heating regime and propose a suitable deformation temperature for a pre-sintered powder-based tungsten heavy alloy workpiece subsequently processed via rotary swaging. The heating regime is designed with the help of numerical analyses and subsequent experiments. The first part of the study focuses on the theoretic background of the induction heating and comprises the development of a reliable induction heating model via performing electromagnetic simulations in two individual computational software packages (for verification). The second part of the study then involves the optimization of the heating regime using the designed numerical model. Last but not least, the predicted results are compared to the experimentally acquired results, and the optimized heating regime, applicable before experimental rotary swaging of the WNiCo workpiece, is proposed. The results of the microstructure analyses of the workpiece heated to the selected optimum deformation temperature of 900 °C showed that the designed induction heating procedure provided sufficient heating of the bulk of the workpiece (contrary to the lower swaging temperature), as the swaged microstructure featured well-deformed tungsten agglomerates. Furthermore, the analyses documented the high-quality oxidation-free surface of the particular workpiece (contrary to the higher swaging temperature).
Microbial Activity in Subterranean Ecosystems: Recent Advances
Authors: Martin-Pozas Tamara , Gonzalez-Pimentel Jose Luis , Jurado Valme , Cuezva Soledad , Dominguez-Moñino Irene , Fernandez-Cortes Angel , Cañaveras Juan Carlos , Sanchez-Moral Sergio , Saiz-Jimenez Cesareo
Published: November 2020

Of the several critical challenges present in environmental microbiology today, one is the assessment of the contribution of microorganisms in the carbon cycle in the Earth-climate system. Karstic subterranean ecosystems have been overlooked until recently. Covering up to 25% of the land surface and acting as a rapid CH4 sink and alternately as a CO2 source or sink, karstic subterranean ecosystems play a decisive role in the carbon cycle in terms of their contribution to the global balance of greenhouse gases. Recent data indicate that microbiota must play a significant ecological role in the biogeochemical processes that control the composition of the subterranean atmosphere, as well as in the availability of nutrients for the ecosystem. Nevertheless, there are still essential gaps in our knowledge concerning the budgets of greenhouse gases at the ecosystem scale and the possible feedback mechanisms between environmental-microclimatic conditions and the rates and type of activity of microbial communities in subterranean ecosystems. Another challenge is searching for bioactive compounds (antibiotics) used for treating human diseases. At present, there is a global health emergency and a strong need for novel biomolecules. In recent decades, great research efforts have been made to extract antibiotics from marine organisms. More recently, caves have been receiving considerable attention in search of novel antibiotics. Cave methanotrophic and heterotrophic bacteria are producers of bioactive compounds and may be potential sources of metabolites with antibacterial, antifungal or anticancer activities of interest in pharmacological and medical research, as well as enzymes with a further biotechnological use. Here we also show that bacteria isolated from mines, a still unexplored niche for scientists in search of novel compounds, can be a source of novel secondary metabolites.
Health Indicators Construction for Damage Level Assessment in Bearing Diagnostics: A Proposal of an Energetic Approach Based on Envelope Analysis
Authors: Brusa Eugenio , Bruzzone Fabio , Delprete Cristiana , Di Maggio Luigi Gianpio , Rosso Carlo
Published: November 2020

Predictive maintenance strategies are established in the industrial context on account of their benefits in terms of costs abatement and machine failures reduction. Among the available techniques, vibration-based condition monitoring (VBCM) has notably been applied in many bearing fault detection problems. The health indicators construction is a central issue for VBCM, since these features provide the necessary information to assess the current machine condition. However, the relation between vibration data and its sources intimately related to bearing damage is not effortlessly definable from a diagnostic perspective. This study discloses a diagnostic investigation performed both on the vibration signal and on the contact pressure signal that is supposed to be one of main forcing terms in the dynamic equilibrium of the damaged bearing. Envelope analysis and spectral kurtosis (SK) are applied to extract and compare diagnostic features from both signals, referring to the Case Western Reserve University (CWRU) case-study. Namely, health indicators are constructed by means of physical considerations based on the effect of faults on the signal power contents. These indicators show to be promising not only for damage detection but, also, for damage severity assessment. Moreover, they provide an invaluable reading key of the link occurring between the contact pressure path and the vibration response.