bluuebunny/crossref_metadata_2025 huggingface dataset:
The Analysis of Learning Infrastructure (LI), Learning Motivation (LM) and Economics Learning Achievement (ELA)
Authors: Setiawan Ananda , Martono Trisno , Gunarhadi Gunarhadi
Published: April 2019

This research aimed to find out whether or not there is an effect of Learning Infrastructure (LI) and Learning Motivation (LM) on Economics Learning Achievement (ELA), and which one has more dominant effect on Learning Achievement, Learning Infrastructure or Learning Motivation. This study was a descriptive quantitative research with survey method. The data of LI, LM and ELA were collected using questionnaire. The population of research consisted of 1192 economics students in Public Senior High Schools of Serdang Bedagai Regency applying the 2013 curriculum. The sample consisted of 300 respondents, taken using cluster areas sampling technique. From the result of research, it can be found that there was a positive significant effect of LI on ELA (tstatistic=9.597, P = 0.000), there was a positive significant effect of LM on ELA (tstatistic=6.990, P=0.000), there was a positive and significant effect of LI and LM on ELA (Fstatistic=114.281, P=0.000), and LI affected ELA more dominantly than LM did.
Enhancing Student Scientific Attitudes towards Civic Education Lesson through Inquiry-based Learning
Authors: Triyanto Triyanto
Published: April 2019

The purpose of this study was to investigate student scientific attitudes toward civic education lesson through inquiry-based learning. The samples in this study were selected using stratified random sampling technique. Interactive data analysis consists of two stages: data collection and data display. The data were gathered by observation and interviews. Statistical results indicated that the student scientific attitudes towards civic education were a positive. Inquiry-based learning enhances student scientific attitude, where the most visible indicator of scientific attitudes is students' curiosity. Building scientific attitude can provide a logical solution to the problem student faced in their daily life and has scientific thinking skills. Creating and using science concepts related to students’ lives and interests will provide opportunities for a student to build their scientific attitude through meaningful learning activities. Scientific attitudes are grown through a series of experiences that students discover on their own during the learning process.
Action Reflected and Project Based Combined Methodology for the Appropriate Comprehension of Mechanisms in Industrial Design Education
Authors: Yavuzcan H. Güçlü , Şahin Damla
Published: April 2019

In industrial design education, mechanics-based courses are mainly based on traditional lecture and they are highly abstract for ID students to comprehend the mechanisms. The existing studies highlight the requirement of a new approach for mechanics-based courses in ID departments. The study presents, a combined teaching model of mechanism mainly based on applied teaching style and action learning to improve ID students' learning experience and competencies through promoting the transference of theoretical knowledge into practical experience and learning. The combined teaching model consisting of 3 phases was integrated to a design studio project that is mechanical game design. Project observations and post-questionnaire were employed to analyze objectively the appropriateness of the teaching model. The results indicated that, the combined teaching model improved ID students' learning outcomes and competencies in terms of transferring the gained theoretical and practical knowledge to the action learning.
Development of Learning Device based Ethnoscience for Heat Material in Kabupaten Tegal
Authors: Susilawati Susilawati , Setiawan Nizar , Khoiri Nur
Published: April 2019

The purpose of this research is produce learning set equipment on heat material of ethnoscience based in Tegal district, The results showed that the feasibility of syllabus-based ethnoscience include into the category is very good because it has a percentage of 96,43%. The feasibility learning device of an ethnoscience-based into a very good category because it has a percentage of 91,37%. Ethnoscience-based learning tool able to improve student learning outcomes from the average value of 42,82 to 80,06 and the gains value 0,65. While the questionnaire of student’s learning interest after the application of physics learning device on ethnoscience based heat material in Kabupaten tegal get the average value 3,01 with the high criteria.
Developing STEM Based Student’s Book for Grade XII Biotechnology Topics
Authors: Wahono Bevo , Rosalina Aini Meitanti , Utomo Anjar Putro , Narulita Erlia
Published: April 2019

The study aims to develop a valid, practical and effective Biology student’s book based on Science Technology Engineering and Mathematics (STEM) on the topic of biotechnology for Grade XII. The method applied for the study was research and development with the 4-D model. The subjects were 58 Grade XII students of SMAN 1 Muncar, Banyuwangi-Indonesia. The results showed that the average of validation result of STEM-based student’s book was 86.4% which fell under a strong valid category. The average percentage of legibility test and practicality were in very good category of 87.18% and 96.53%, respectively. Meanwhile, the average of effectiveness test was 0.77 of normalized gain categorized in high criteria. In conclusion, it could be determined that STEM-based student’s book of biotechnology is valid, pratical, and effectively used in learning process.
Developing Assessment Instrument as a Mathematical Power Measurement
Authors: Kusmaryono Imam , Suyitno Hardi , Dwijanto Dwijanto , Dwidayati Nurkaromah
Published: April 2019

This was a field research (literature review and exploration) with descriptive quantitative approach. This study aims: (1) to develop a model (scheme) to assess mathematical power, (2) to test the validity of instruments of mathematical power assessment, and (3) to developa valid and reliable test and non-test instrument prototypes as a mathematical power measurement. The research instruments consist of 4 items of essay test, 20 sheets of observation on investigative activities, and 20 items of questionnaires. Validity test was conducted through constructions built up from 3 aspects of mathematical power ability. Result of instrument analysis showed that: (1) the r of instrument test = 0.947, meaning that the instrument is reliable, (2) the r of activity observation sheets = 0.912, meaning that the instrument is reliable, and (3) the r of questionnaires = 0.770, meaning that the questionnaire is reliable on 0.05 significance level. This study concludes: (a) the steps in the model (scheme) of mathematical power assessment may be used as a reference for assessing mathematical power, (b) test and non-test instruments are valid and reliable, and (c) prototypes of test and non-test instruments may be used as a measurement in mathematical power assessment.
Enhancing Students’ Argumentation Skill Using an Argument Driven Inquiry-Based Module
Authors: Amielia Shinta Devi , Suciati Suciati , Maridi Maridi
Published: April 2019

Argumentation skills as a form of communication to externalize ideas through scientific discourse is a very important in learning of science. As an integral part of the science, argumentation skills should be integrated as a component of learning science. The purpose of this study is to determine the effectiveness of argument driven inquiry-based module in enhanching the students’ argumentation skills. This study was conducted at one of the State Senior High School in Surakarta academic year 2016/2017. The pre-test and post-test research pattern with treatment and control class groups were used throughout the study. While the treatment group taught by using module based on argument-driven inquiry, the control group was taught by a module that commonly used in the school. As the study concluded, using argument driven inquiry-based module in the learning process is effective to enhance the quality of students’ argumentation skills.
The Effect of Gratitude on Parental Stress among Mothers’ of Early Children
Authors: Kristiana Ika Febrian , Hyoschamina Darosy Endah , Fatimah Niken
Published: April 2019

The stress of parenting as a distress experience in carrying out the demands of parenting role becomes greater experienced by the mother as the primary caregiver as a culture in Indonesia. Be grateful to be a strength-based intervention aimed at strengthening positive emotions and protecting individuals from psychological problems. This experimental study aims to test the effectiveness of gratitude in reducing maternal stress. The experimental design between subjects was selected by dividing the 70 mothers who had early childhood into two groups: the experimental and control group. The data analysis using 2 independent samples test with R statistic showed (p = .023; Cohen's d = .183), and Wilcoxon 2 related samples test (p = .0087) showed that gratitude training was effective to decrease maternal stress. Being grateful for a moral response based on personal reinforcement through thoughts, emotions, and positive and pleasant attitudes that then lead to the ability to give goodness to others. The findings of this study become interesting when examined also from the social context such as the existence of social support where the attitude of gratitude is related to it.
Acceptability of Children with Special Needs in the Inclusive Elementary School
Authors: Kurniawan Muhammad Ragil , Rofiah Nurul Hidayati
Published: April 2019

The main obstacle of children with special needs to advance is access to education as high as possible not to the disability, but to social acceptance of the community. This study aims 1) To determine the acceptability of children with special needs in the inclusive elementary school environment. It includes principals, teachers, learners, and parents. 2) To determine the factors those influence the acceptance of children with special needs in the inclusive elementary school environment. This is an interactive qualitative research. The research site is Wirosaban Elementary School, Yogyakarta City. Data collection techniques are interviews, observation and documentation. Data analysis technique is analytic descriptive data analysis. The results show: 1) Acceptability of children with special needs in inclusive school environment is quite good after going through various processes. School trying to accept children with special needs even though the school realized its service on some things still not maximal 2) There are four factors that affect the school environment perception of children with special needs. These factors are: knowledge and insight factor on inclusive education, b. environmental support factor outside the school, c. facilities factor, d. the persistence factor of the guardians of the special needs students.
The Development of Inquiry Science Worksheet to Facilitate the Process Skills
Authors: Servitri Margaretha Ordo , Trisnawaty Wulan
Published: April 2019

This research aimed for developing Inquiry Worksheet to facilitate the process skill. Inquiry Worksheet gave the opportunity for student to make good observations in giving hypothesis, designing the experiment, collecting, analyzing, and inferring the data. To involve the students in Inquiry process is the important point in Science lessons which can help the students to develop Science literacy and give the opportunity to drill their Science process skill. This research used the steps of developing 4P but the fourth step was not used, this analysis used the descriptive qualitative. Based on the validation result showed the Lesson Plan (RPP) and Inquiry Worksheet (LKS) had been developed were in valid category. The implementation of the good Lesson Plan for Evaluation Results was classically achieved. The process skill obtained 100 for the average score. For pretest and posttest, the students obtained 82.85 and 57.14. Learning using the Inquiry worksheet showed good responses by the students. The conclusion of this research was Inquiry Worksheet competent to facilitate the process skills.
The Effectiveness of Augmented Reality App to Improve Students Achievement in Learning Introduction to Animals
Authors: Markamah Nisaun , Subiyanto Subiyanto , Murnomo Agus
Published: April 2019

In this experimental study, AR book app is used to improve student learning outcome of kindergarten in animals introduction subject. AR book app is an application based on Augmented Reality (AR) technology that adapts the kindergarten curriculum in Indonesia. AR book app has included 3D view and animals video. 3D based learning makes it easy for students to visualize learning materials and video-based learning to makes students give attention when learning activity. In a field experiment at kindergarten, 111 kindergarten students were divided into two groups participated in the learning activity that using different learning media. The two groups were group A and group B. Group A is an experimental group which taught using Augmented Reality (AR) book app. Group B is control group which taught using group note methods. Experimental result showed that students’ performance in learning improved significantly by using Augmented Reality (AR) book app media. In this study, students indicated that the experimental group learning outcome is better than the control group.
Secondary school students’ errors and misconceptions in learning algebra
Authors: Ndemo Zakaria , Ndemo Osten
Published: April 2019

The aim of the study is to develop an understanding of the kinds and sources errors and misconceptions that characterise students’ learning of school algebra. Systematic random sampling was used to draw sixty-five participants from a population of two hundred and twenty-three form three students. A cross sectional survey design was employed to collect data using written tests, a structured questionnaire and interviewing of the students from one high school in Zimbabwe. Content analysis technique was applied to textual data from three sources in order to determine the types of errors and misconceptions. The main findings are that both procedural and conceptual errors were prevalent that errors and misconceptions can be explained in terms of the students’ limited understanding of the nature of algebra; in particular their fragile grasp of the notion of a variable. Sources of misconceptions could be explained in terms of the abstract nature of algebra Mathematics educators should embrace errors and misconceptions in their teaching and should not regard them as obstacles to learning but rather engage with them for better understanding of algebraic concepts by students. Future studies can be carried on systematic errors as one of the ways of improving students’ understanding school mathematics.
Critical Thinking Skills of Prospective Elementary School Teachers in Integrated Science-Mathematics Lectures
Authors: Fitria Yanti , Hasanah Fiddinya Nurul , Gistituati Nurhizrah
Published: April 2019

The purpose of this study is to find out the critical thinking skills indicators and aspects of prospective elementary school teachers in mathematics-science integration lectures on electrical circuits and mathematical logic lesson. This research uses random sampling technique in which 30 first semester students were chosen randomly from one of university in Padang region West Sumatera Indonesia. This research uses Research and Development (R D). The critical thinking skills are seen from processes, observations, and tests. The process of critical thinking skills of prospective elementary school teachers on the average of critical thinking skills indicator is 84% in strategies and tactics, 80% in advanced clarification and 83% in elementary clarification, basic support, and inference. The result of observing the critical thinking skills of prospective elementary school teachers on the average of each lectures is significantly increased to be 81.9%. The results of pre-test and post-test were increased significantly. It is shown from N-gain of 0.7 to be medium category.
Performance of mathematics teachers to build students' high order thinking skills (HOTS)
Authors: Tambunan Hardi , Naibaho Tutiarny
Published: April 2019

The purpose of this study is to determine the mathematics teacher performance category in building high order thinking skills (HOTS) of students. The study was conducted on 560 students taken randomly from ten junior high schools and eight high schools from eight districts in North Sumatra Province. Data collection techniques and instruments are carried out by giving questionnaires to students which contain a number of questions about students' assessment of the mathematics teacher's performance in constructing the HOTS indicator. Based on descriptive analysis, it was found that the performance of mathematics teachers built HOTS indicators, namely (1) understanding of concepts, (2) mathematical communication, (3) creativity, (4) problem solving, and (5) reasoning is enough category. The results of analysis of variance show that teacher performance builds (1) understanding of concepts, (2) mathematical communication, (3) creativity, (4) problem solving, and (5) reasoning significantly influences students' abilities.
School environment role towards elementary school students’ moral and cultural literacy
Authors: Maryani Ika , Prawestri Ianah Hasnatul , Sulisworo Dwi , Urbayatun Siti , Suyatno Suyatno , Bhakti Caraka Putra
Published: April 2019

This study aims to determine the role of the school environment on moral and cultural literacy of elementary school students. This is descriptive qualitative research. Data collection techniques are observation, interviews, questionnaire, and documentation. Data analysis techniques are data reduction, data presentation, and conclusions. Data validity using triangulation. Triangulation is to ensure the data validity that takes into consideration aspects of credibility, transferability, dependability, and confirmability. The subjects are 3 teachers and 27 students of 4th, 5th and 6th grade in Muhammadiyah School of Sleman Regency. The results of this study are (1) teachers-students’ relationships have role to foster the character of honesty, fairness, caring, and teachers as role model for students; (2) students-students’ relationships also have role to habituate good behavior to students; (3) school discipline contributes to the students’ moral and cultural formation such as self-awareness, honesty, justice, responsibility, obedience to the rules, good commitment and unfazed by the changing era; (4) these learning implements have role in self-awareness, responsibility and care, because the teaching implements provided by the teachers becomes the students’ responsibility.
Power flow management of triple active bridge for fuel cell applications
Authors: Kudithi Nageswara Rao , Somkun Sakda
Published: April 2019

The power conditioning circuits which are used in fuel cell systems should carefully be designed to prolong the life span of the system, for the reason of the dynamic nature, such that the unexpected and extreme changes in load decreases the life of the fuel cells. This paper presents the triple active bridge (TAB) and it’s average small signal modelling, which is used for design of the system controllers for stable operation. The extended symmetrical optimum method is used for realized the proportional integral (PI) controller, to control the output/Load voltage and power flow in the fuel cell/Source with a guaranteed minimum phase margin for the system with a variable process gain in addition to other accepted desired performances. This method ensures the maximum phase margin at a minimum required value at the desired gain crossover frequency with a compromise between system’s peak overshoot, rise time and settling time. This model and this approach helps in designing TAB suitable for healthy and uninterrupted fuel cell power generation systems as a part of a renewable /clean energy system. MATLAB/Simulink is used to simulate the proposed controllers with TAB.
DTC hybrid by different techniques of observation with Artificial Neuronal Network (ANN) for induction machine drives
Authors: Ahmed Dris , Bendjebbar Mokhtar , Belaidi Aek
Published: April 2019

In this article, we present the construction of observers of rotor flux and mechanical speed needed for robust control of the induction machine. Two observers will be developed for comparison. The first is based on the techniques MRAS and the second is observer of KUBOTA, with the enhanced DTC-ANN (by artificial intelligence), "sensorless DTC-ANN". The validity of the proposed methods is confirmed by the simulation results. Through this comparative study we examine each observer in terms of characteristics that distinguish him from the other through these estimated value and error of estimation (flux and the speed of rotation) on the one hand, and on the other hand we study a property of great importance in the control and the response and robustness of the observer for very low speeds.
In my work I concentrate this on the observer of KUBOTA because I noticed that during my research in the previous research and research there is very little and no detail even in terms of mathematical model in addition to the form of comparative study between him and the observer of MRAS in terms of the principle of control, accuracy, sensitivity and special response to low speeds and error In observation.The THD (Total Harmonic Distortion) of stator current, torque ripple and stator flux ripple are determined and compared with conventional DTC control scheme using Matlab/Simulink environment.
Backstepping control of two-mass system using induction motor drive fed by voltage source inverter with ideal control performance of stator current
Authors: Ha Vo Thanh , Tan Le Trong , Nam Nguyen Duc , Quang Nguyen Phung
Published: April 2019

This paper describes the design and the simulation of a non-linear controller for two-mass system using induction motor basing on the backstepping method. The aim is to control the speed actual value of load motor matching with the speed reference load motor, moreover, electrical drive’s respone ensuring the “fast, accurate and small overshoot” and reducing the resonance oscillations for two-mass system using induction motor fed by voltage source inveter with ideally control performance of stator current. Backstepping controller uses the non-linear equations of an induction motor and the linear dynamical equations of two-mass system, the Lyapunov analysis and the errors between the real and the desired values. The controller has been implemented in both simulation and hardware-in-the-loop (HIL) real-time experiments using Typhoon HIL 402 system, when the drive system operates at a stable speed (rotor flux is constant) and greater than rated speed (field weakening area). The simulation and HIL results presented the correctness and effectiveness of the controller is proposed; furthermore, compared to PI method to see the response of the system clearly.
A review on different control techniques using DSTATCOM for distribution system studies
Authors: Swetha K. , Sivachidambaranathan V.
Published: April 2019

This paper focus on distribution system by applying different control techniques in order to improve the performance of the system. In the distribution system mainly concentrate on power quality issues like reactive power control, harmonic elimination, power factor correction, etc. Because of power quality problems voltage, current, frequency are continuously changing in power systems. These changes will effects the performance of power systems. Power quality problems can be compensated by placing DSTATCOM which is connected at PCC in parallel. It is shunt connected VSI along with the filters, with the help of DSTATCOM voltage sag, swell and THD can be controlled. This paper presents detailed explanation about performance and configuration of latest control techniques to control the DSTATCOM.
An adaptable different-levels cascaded h-bridge inverter analysis for PV grid-connected systems
Authors: Ali Adnan Hussein , Hamad Hassan Salman , Abdulrazzaq Ali Abdulwahhab
Published: April 2019

Multi-level inverters (MLIs), have gained popularity in the last few years as a result of their low total harmonic distortions (THD) as well as their output waveform which is of high quality. The converter which considers more appropriate for applications of photovoltaic (PV)beyond the varying MLIs arrangementsis the Cascaded H-Bridge-(CHB) (MLI), meanwhile each PV panel may be served as an independent DC supply for any CHB unit. Through the use of MATLAB/Simulink, the efficiency of symmetrical single phase MLI in terms of the number of switches, harmonic content in addition to the stresses of voltage through theswitches that exist at photovoltaic cell by means of input source is enhanced; varying parameters like output current, voltage and power, and THD at 5-level 7-level and 9-level Cascaded MLI are observed. In this paper, attention is paid to a multi-level topologies which is flexible and based on cascaded MLI intended for PV grids connected system. An observation of the output voltage becomes closer to the sine wave as the levels increase, while the increase in the levels of Cascaded Multilevel Inverter causes the total harmonic distortion to decrease.
Stand-alone PV system with MPPT function based on fuzzy logic control for remote building applications
Authors: Attia Hussain A. , Gonzalo Fernando DelAma
Published: April 2019

Due to the limitations of reaching the grid utility to remote area, such as rural and/or countryside areas.  Stand-alone photovoltaic power systems represent good alternative that it can be adapted for electrical power delivering to these areas. In this paper, a new design of stand-alone solar system suitable for individual building application is presented. This study focuses on proposing a desired solar PV panels matrix arrangement and connection, in addition to presenting an accurate design of Buck-Boost DC-DC converter which controlled by fuzzy logic controller FLC. The controller guarantees the maximum Power Point working conditions and manipulates the fluctuation of the DC link voltage of the matrix due to the weather changing. The main system includes battery bank charger, single phase inverter, and passive power filter. This study addresses the design and performance analysis the DC side of the 7.85 kW PV system. The system performance is evaluated through MATLAB/Simulink results which reflected the promising indications as an effective system for rural individual stand-alone building applications. 
EDM process through mathematical model
Authors: Dehghani Dana , Yahya Azli , Khamis Nor Hisham , Alzaidi Ali Idham
Published: April 2019

EDM is a well-established hole machining option with various advantages due to non-contact characteristics of the process. However, knowledge about the process is not enough for its more improvements. Exprimenal studies are costly and time consuming because of the complex nature of process. Therefore, process modeling is a good alternative to reduce the experimental expense related to the technology. This paper studys EDM process through mathematical model, which includes the precise insight into the interactive behavior of EDM system. The ignition, discharge and recovery phases of the model have been developed through MATLABs time domain analysis. Simulation result shows good agreement with expected profile of EDM spark. To verify the model, simulated material removal rates (MRRs) from series of simulation are compared with the experimental ones reported by previous researcher. Ability of the model to predict the dynamic behavior profile of the EDM system is successfully confirmed by low average percentage error in predicting MRR.
Radiographic imaging pattern of ossifying fibroma mimicking ameloblastoma
Authors: Tenório Jefferson Rocha , Kobayashi-Velasco Solange , Nunes Fábio Daumas , Cavalcanti Marcelo Gusmão Paraiso
Published: April 2019

Radiographic examinations complement the anamnesis and physical exam with the purpose of reaching diagnosis, prognosis and treatment planning. In this case report, a 48 year-old male Caucasian patient was referred to an oral and maxillofacial surgeon by a general practitioner after a panoramic radiography for treatment planning; the implant surgery follow-up portrayed a multilocular radiolucent image at the left posterior mandible. Based solely on the panoramic radiography, the diagnostic hypothesis was ameloblastoma. The surgeon decided to perform an incisional biopsy. However, during the procedure, the professional noted that the lesion was easily detached from the adjacent bone and opted for the total removal of the lesion, thus altering its diagnostic hypothesis to central ossifying fibroma (COF). The histopathological result confirmed the diagnostic hypothesis provided by the surgeon, i.e. COF. Although multilocular presentation is not common, COF should be considered in the scope of multilocular radiolucent lesions of the jaws. In addition, computerized tomography imaging exam complemented by surgical and histopathological aspects should be considered for establishing the final diagnosis and conducting the therapeutic approach.
Prevalência de sinusopatias maxilares por meio de tomografia computadorizada de feixe cônico
Authors: Barbosa Cinthia Palmira , Silva Milena Bortolotto Felippe , Araujo Juliane Pirágine , Raitz Ricardo
Published: April 2019

O objetivo deste trabalho foi avaliar a prevalência de sinusopatias nos seios maxilares (SM) por meio de tomografias computadorizadas de feixe cônico (TCFC) da maxila em pacientes selecionados de acordo com gênero e idade para o planejamento de implantes dentários. As 226 imagens tomográficas selecionadas foram analisadas independentemente por três cirurgiões dentistas (CD) especialistas com o intuito de verificar a presença de sinusopatias. As anormalidades encontradas foram: velamento sinusal, espessamento mucoso, pseudocisto antral, pólipos, e pneumatização. Das 226 TCFC analisadas, encontramos a presença de sinusopatias em 156 (69%), sob a forma de velamento sinusal em 69 (30,5%), espessamento mucoso em 63 (27,9%), pneumatização em 57 (25,2%), pseudocisto antral em 29 (12,8%) e pólipos em seis (2,7%), podendo ocorrer isolada ou simultaneamente. Quando observamos a ocorrência simultânea de duas ou mais sinusopatias, estas estiveram presentes em 56 (24,8%) das TCFC observadas na amostra. O espessamento mucoso e pneumatização foram as mais frequentes, tendo ocorrido em 8,4% da amostra. Quanto ao gênero, não houve diferença entre os gêneros masculino e feminino no que diz respeito à prevalência das sinusopatias nos SM. Houve diferença entre faixas etárias apenas para pólipo, sendo que indivíduos com idade acima de 61 anos apresentaram maior taxa de prevalência. Nosso estudo mostra a importância da TCFC para implantes na maxila posterior em razão da alta prevalência de sinusopatias encontradas em pacientes assintomáticos.
Jogos, espetáculos e competições na Palestina romana
Authors: Porto Vagner Carvalheiro
Published: April 2019

Este texto tem por objetivo apresentar os jogos e competições que eram realizados na Palestina romana. Poderão ser observadas nas linhas que seguem as diversas construções de Herodes, o Grande, também conhecido como rei-construtor, no campo dos espetáculos. Destacam-se a Liberalitas Augusti, generosidade, de Herodes, e a inserção da romanitas na região, a partir, principalmente, de suas obras. A documentação textual e a documentação material ditarão os caminhos do conhecimento acerca das estruturas relacionadas aos jogos na Palestina romana, seja por seus teatros, anfiteatros e hipódromos, seja pelos hábitos culturais daí advindos
Efficacy and Safety of Firibastat, A First-in-Class Brain Aminopeptidase A Inhibitor, in Hypertensive Overweight Patients of Multiple Ethnic Origins
Authors: Ferdinand Keith C. , Balavoine Fabrice , Besse Bruno , Black Henry R. , Desbrandes Stephanie , Dittrich Howard C. , Nesbitt Shawna D. ,   On behalf of the NEW HOPE Investigators
Published: April 2019

Background:

Despite existing therapy, successful control of hypertension in the United States is estimated at less than 50%. In blacks, hypertension occurs earlier, is more severe, controlled less often and has a higher morbidity and mortality than in whites. Blacks are also less responsive to monotherapy with angiotensin-I converting enzyme inhibitors or angiotensin-II receptor type 1 blockers. Obesity, higher salt-sensitivity and low plasma renin activity are possible reasons of this poor blood pressure (BP) control, especially in blacks. The aim of the study was to assess efficacy and safety of firibastat, a first-in-class aminopeptidase A inhibitor preventing conversion of brain angiotensin-II into angiotensin-III, in BP lowering in a high-risk diverse hypertensive population.

Methods:

Two hundred fifty-six overweight or obese hypertensive patients, including 54% black and Hispanic individuals, were enrolled in a multicenter, open-label, phase II study. After a 2-week wash-out period, subjects received firibastat for 8 weeks (250 mg BID orally for 2 weeks, then 500 mg BID if automated office blood pressure (AOBP) >140/90 mm Hg; hydrochlorothiazide 25 mg QD was added after 1 month if AOBP ≥160/110 mm Hg). The primary end point was change from baseline in systolic AOBP after 8 weeks of treatment, and secondary end points include diastolic AOBP, 24-hour mean ambulatory BP and safety.

Results:

Firibastat lowered systolic AOBP by 9.5 mm Hg (
P
<0.0001) and diastolic AOBP by 4.2 mm Hg (
P
<0.0001). 85% of the subjects did not receive hydrochlorothiazide and were treated with firibastat alone. Significant BP reduction was found across all subgroups regardless age, sex, body mass index, or race. Systolic AOBP decreased by 10.2 mm Hg (
P
<0.0001) in obese patients, by 10.5 mm Hg (
P
<0.0001) in blacks, and 8.9 mm Hg (
P
<0.0001) in nonblacks. Most frequent adverse events were headaches (4%) and skin reactions (3%). No angioedema was reported. No change in potassium, sodium, and creatinine blood level were observed.

Conclusions:

Our results demonstrate the efficacy of firibastat in lowering BP in a high-risk diverse population where monotherapy with angiotensin-I converting enzyme inhibitors or angiotensin-II receptor type 1 blockers may be less effective and support the strategy to further investigate firibastat in subjects with difficult-to-treat or potentially resistant hypertension.

Clinical Trial Registration:

URL:
https://www.clinicaltrials.gov
. Unique Identifier: NCT03198793.
Metabolomics Profiling of Visceral Adipose Tissue: Results From MESA and the NEO Study
Authors: Neeland Ian J. , Boone Sebastiaan C. , Mook‐Kanamori Dennis O. , Ayers Colby , Smit Roelof A. J. , Tzoulaki Ioanna , Karaman Ibrahim , Boulange Claire , Vaidya Dhananjay , Punjabi Naresh , Allison Matthew , Herrington David M. , Jukema J. Wouter , Rosendaal Frits R. , Lamb Hildo J. , van Dijk Ko Willems , Greenland Philip , de Mutsert Renée
Published: April 2019

Background

Identifying associations between serum metabolites and visceral adipose tissue (
VAT
) could provide novel biomarkers of
VAT
and insights into the pathogenesis of obesity‐related diseases. We aimed to discover and replicate metabolites reflecting pathways related to
VAT
.

Methods and Results

Associations between fasting serum metabolites and
VAT
area (by computed tomography or magnetic resonance imaging) were assessed with cross‐sectional linear regression of individual‐level data from participants in MESA (Multi‐Ethnic Study of Atherosclerosis; discovery, N=1103) and the NEO (Netherlands Epidemiology of Obesity) study (replication, N=2537). Untargeted
1
H nuclear magnetic resonance metabolomics profiling of serum was performed in
MESA,
and metabolites were replicated in the
NEO
study using targeted
1
H nuclear magnetic resonance spectroscopy. A total of 30 590 metabolomic spectral variables were evaluated. After adjustment for age, sex, race/ethnicity, socioeconomic status, smoking, physical activity, glucose/lipid‐lowering medication, and body mass index, 2104 variables representing 24 nonlipid and 49 lipid/lipoprotein subclass metabolites remained significantly associated with
VAT
(
P
=4.88×10
−20
–1.16×10
−3
). These included conventional metabolites, amino acids, acetylglycoproteins, intermediates of glucose and hepatic metabolism, organic acids, and subclasses of apolipoproteins, cholesterol, phospholipids, and triglycerides. Metabolites mapped to 31 biochemical pathways, including amino acid substrate use/metabolism and glycolysis/gluconeogenesis. In the replication cohort, acetylglycoproteins, branched‐chain amino acids, lactate, glutamine (inversely), and atherogenic lipids remained associated with
VAT
(
P
=1.90×10
−35
–8.46×10
−7
), with most associations remaining after additional adjustment for surrogates of
VAT
(glucose level, waist circumference, and serum triglycerides), reflecting novel independent associations.

Conclusions

We identified and replicated a metabolite panel associated with
VAT
in 2 community‐based cohorts. These findings persisted after adjustment for body mass index and appear to define a metabolic signature of visceral adiposity.
Coronary Microcirculation Downstream Non‐Infarct‐Related Arteries in the Subacute Phase of Myocardial Infarction: Implications for Physiology‐Guided Revascularization
Authors: Mejía‐Rentería Hernán , Lee Joo Myung , van der Hoeven Nina W. , Gonzalo Nieves , Jiménez‐Quevedo Pilar , Nombela‐Franco Luis , Núñez‐Gil Iván J. , Salinas Pablo , Del Trigo María , Cerrato Enrico , van Royen Niels , Knaapen Paul , Koo Bon‐Kwon , Macaya Carlos , Fernández‐Ortiz Antonio , Escaned Javier
Published: April 2019

Background

Concerns exist about reliability of pressure‐wire‐guided coronary revascularization of non‐infarct‐related arteries (non‐
IRA
). We investigated whether physiological assessment of non‐
IRA
during the subacute phase of myocardial infarction might be flawed by microcirculatory dysfunction.

Methods and Results

We analyzed non‐
IRA
that underwent fractional flow reserve, coronary flow reserve, and the index of microcirculatory resistance assessment. Microcirculation and hyperemic response were evaluated in 49 acute myocardial infarction patients (59 non‐
IRA
) and compared with a matched control group of 46 stable angina (
SA
) patients (59 vessels). Time between acute myocardial infarction to physiological interrogation was 5.9±2.4 days. Fractional flow reserve was similar in both groups (0.79±0.11 in non‐
IRA
versus 0.80±0.13 in
SA
vessels,
P
=0.527). Lower coronary flow reserve values were found in non‐
IRA
compared with
SA
vessels (1.77 [1.25–2.76] versus 2.44 [1.63–4.00],
P
=0.018), primarily driven by an increased baseline flow in non‐
IRA
(rest mean transit time 0.58 [0.32–0.83] versus 0.65 s [0.39–1.20],
P
=0.045), whereas the hyperemic flow was similar (hyperemic mean transit time 0.26 [0.20–0.42] versus 0.26 s [0.18–0.35],
P
=0.873). No differences were found regarding index of microcirculatory resistance (15.6 [10.4–21.8] in non‐
IRA
versus 16.7 [11.6–23.6] U in
SA
vessels,
P
=0.559). During adenosine infusion, the hyperemic response was similar in both groups (non‐
IRA
versus
SA
vessels) in terms of the resistive reserve ratio (3.1±2.1 versus 3.7±2.2,
P
=0.118).

Conclusions

In the subacute phase of myocardial infarction, non‐
IRA
show an increased baseline flow that may cause abnormal coronary flow reserve despite preserved hyperemic flow. In non‐
IRA
, microcirculatory resistance and adenosine‐induced hyperemic response are similar to those found in
SA
patients. From a physiological perspective, these findings support the use of fractional flow reserve to interrogate non‐
IRA
during the subacute phase of myocardial infarction.
Ending a 175-year taxonomic uncertainty: Description of Staurosirella neopinnata sp. nov. (Bacillariophyta) to accommodate Fragilaria pinnata, a highly misconstrued taxon with a purported worldwide distribution
Authors: MORALES EDUARDO ANTONIO , WETZEL CARLOS EDUARDO , HAWORTH ELIZABETH Y. , ECTOR LUC
Published: April 2019

Fragilaria pinnata Ehrenberg is actually a member of the genus Denticula Kützing. However, due to a drift of its taxonomic concept, there is now a “floating” idea of F. pinnata as an araphid diatom associated to Staurosirella D.M.Williams & Round (as S. pinnata (Ehrenberg) D.M.Williams & Round). Upon investigation of the nomenclatural history of F. pinnata and examination of type material of Staurosirella mutabilis (W.Smith) E.Morales & Van de Vijver (= Odontidium mutabile (W.Smith) Kützing), a commonly reported synonym for S. pinnata, it became evident that the material studied in depth by Haworth (1974, 1975, 1976) is the most suitable to give a formal taxonomic concept to that floating idea. For this purpose, we describe a new species, Staurosirella neopinnata, from the mentioned material. This diatom is distinguished by the raised axial area and virgae, and the solid, apically flattened spines, originating from two or three points on the virgae. The largest population found in the analyzed material corresponds to a depth of 208 cm in a sediment core (early Flandrian, ca. 10226 +/- 190 YBP) from Loch Borralan, Scotland, a shallow lake exposed to wind disturbance and containing, at that depth, a diatom assemblage characterized by a high density of S. neopinnata and benthic forms that are alkaliphilous, halobion and current indifferent, non-aerophilic and non-cryophilic. Through a review of electron microscopy images in the literature, we preliminarily establish that the new taxon has a Holarctic distribution and that the great majority of F. pinnata reports from other biogeographic realms correspond to different, as yet formally undescribed species.
DNA barcodes reveal cryptic genetic diversity within the blackfly subgenus Trichodagmia Enderlein (Diptera: Simuliidae: Simulium) and related taxa in the New World
Authors: HERNÁNDEZ-TRIANA LUIS MIGUEL , CRAINEY JAMES LEE , HALL ANDY , FATIH FARRAH , MACKENZIE-DODDS JACQUELINE , SHELLEY ANTHONY JOHN , ZHOU XIN , POST RORY J. , GREGORY T. RYAN , HEBERT PAUL DAVID NEIL
Published: April 2019

In this paper we investigate the utility of the COI DNA barcoding region for species identification and for revealing hidden diversity within the subgenus Trichodagmia and related taxa in the New World. In total, 24 morphospecies within the current expanded taxonomic concept of Trichodagmia were analyzed. Three species in the subgenus Aspathia and 10 species in the subgenus Simulium s.str. were also included in the analysis because of their putative phylogenetic relationship with Trichodagmia. In the Neighbour Joining analysis tree (NJ) derived from the DNA barcodes most of the specimens grouped together according to species or species groups as recognized by other morphotaxonomic studies. The interspecific genetic divergence averaged 11.2% (range 2.8–19.5%), whereas intraspecific genetic divergence within morphologically distinct species averaged 0.5% (range 0–1.2%). Higher values of genetic divergence (3.2–3.7%) in species complexes suggest the presence of cryptic diversity. The existence of well defined groups within S. piperi, S. duodenicornium, S. canadense and S. rostratum indicate the possible presence of cryptic species within these taxa. Also, the suspected presence of a sibling species in S. tarsatum and S. paynei is supported. DNA barcodes also showed that specimens from species that were taxonomically difficult to delimit such as S. hippovorum, S. rubrithorax, S. paynei, and other related taxa (S. solarii), grouped together in the NJ analysis, confirming the validity of their species status. The recovery of partial barcodes from specimens in collections was time consuming and PCR success was low from specimens more than 10 years old. However, when a sequence was obtained, it provided good resolution for species identification. Larvae preserved in ‘weak’ Carnoy’s solution (9:1 ethanol:acetic acid) provided full DNA barcodes. Adding legs directly to the PCR mix from recently collected and preserved adults was an inexpensive, fast methodology to obtain full barcodes. In summary, DNA barcoding combined with a sound morphotaxonomic framework provides an effective approach for the delineation of species and for the discovery of hidden diversity in the subgenus Trichodagmia.
An Annotated Catalog of the Iranian Coreidae, Rhopalidae, and Stenocephalidae (Hemiptera: Heteroptera: Pentatomomorpha: Coreoidea)
Authors: GHAHARI HASSAN , MOULET PIERRE , LINNAVUORI RAUNO E. , OSTOVAN HADI
Published: April 2019

A study of Iranian Coreoidea, Alydidae excluded, has brought new geographical data on these bugs. Ninety-five species in 34 genera of three families, including, Coreidae (53 species), Rhopalidae (33 species), and Stenocephalidae (9 species), are listed as the fauna of Iran. The following species of Coreidae are new for the Iranian fauna: Fracastorius cornutus Distant 1902, Homoeocerus albiguttulus Stål 1873, and Prismatocerus borealis (Distant 1918).
A new genus and five new species of the Meconematini (Orthoptera: Tettigoniidae: Meconematinae)
Authors: WANG HANQIANG , LIU XIANWEI , LI KAI , FANG YAN
Published: April 2019

In the present paper, one new genus Allocyrtopsis gen. nov. and 5 new species including 1 new in the genus Neocyrtopsisare described. A key to genera and species are provided. All type specimens are deposited in the SEM (Shanghai Entomological Museum, CAS).
A new species of Platepistoma Rathbun, 1906 (Decapoda: Brachyura: Cancridae) from deep water off South Africa
Authors: DAVIE PETER J. F. , NG PETER K. L.
Published: April 2019

Platepistoma seani sp. nov. is described from deep water off KwaZulu-Natal Province, South Africa. It can be separatedfrom its nearest relative, Platepistoma guezei (Crosnier, 1976), by its thicker setal covering that completely hides the an-terolateral teeth from dorsal view, less well defined carapace regions, more spinous anterolateral and posterolateral cara-pace margins, sparser but more prominent dorsal carapace spines, more prominent spines on the carpus of the cheliped, and a relatively narrower male telson.
A new species of Yphthimoides (Lepidoptera: Nymphalidae: Satyrinae) from the southern Atlantic forest region
Authors: FREITAS ANDRÉ V. L. , KAMINSKI LUCAS A. , MIELKE OLAF H. H. , BARBOSA EDUARDO P. , SILVA-BRANDÃO KARINA L.
Published: April 2019

This paper describes a new, abundant and widespread species of Yphthimoides Forster from the Atlantic forests of southern Brazil, Paraguay, and northern Argentina (Misiones) in open and secondary vegetation and forest edges. Adult and immature stage morphology is described, molecular data are provided, and the placement of the new species within the genus Yphthimoides is discussed.
Two new species of the tribe Oligaphorurini Bagnall, 1949 (Collembola: Onychiuridae) from northeast China
Authors: SUN XIN , WU DONGHUI
Published: April 2019

Two new species of the tribe Oligaphorurini are described from northeast China: Dimorphaphorura jingyueensis sp. nov. and Oligaphorura chankaensis sp. nov. Dimorphaphorura jingyueensis sp. nov. is similar to Dimorphaphorura pseudoraxensis (Nosek & Christian, 1983) in having 1+1, 3+3, and 3+3 pso on Th. I–III, respectively. Both species can be distinguished by the number of pso on Abd. IV–V, the ratio of unguiculus/unguis, the inner basal lamella of the unguiculus, the number of chaetae in distal whorl of the tibiotarsi and of the apical teeth on mandible. Oligaphorura chankaensis sp. nov. is similar to the species O. montana Weiner, 1994 and O. pseudomontana Sun & Wu, 2012 in the same number of pso on the dorsal side of head and Th. I–Th. III terga (43/144), ventral pso formula (11/000/00000) and pso on subcoxa 1 of legs I–III (1, 1, 1). But the new species can be separated from them by the number of pso on abdominal terga, the ventral psx formula, the labial type, the number of chaetae on tibiotarsi I–III and the ratio of AS/unguis.