bluuebunny/crossref_metadata_2025 huggingface dataset:
Expression of p53 and Bcl2 Mammary Adenocarcinoma in C3H Mice Administered With Salvia miltiorrhizae Bunge root extract
Authors: Dewi Liza Suryani , Widjayahadi Noor , Wijaya Indra
Published: July 2018

Background: Breast cancer is on the first or second most malignancy in many places around the world. The incidence of breast cancer was increasing, also in Indonesia. Prevention and treatment of breast cancer have not been satisfactory, since patients and medical practitioners are searching for other therapeutic and preventive agents. Salvia miltiorrhizae Bunge roots is one of the therapeutics agent used in traditional medicine have been studied in foreign country.Objective: To prove the p53 and Bcl2 expression in C3H mice mammary adenocarcinoma using multilevel doses of the Salvia miltiorrhizae Bunge roots extract. Methods :The study is a randomized post-test only controlled group design. A total of 18 adenocarcinoma mice, divided into 3 groups. The first group was administered with 60mg/KgBW/day and the second group was given by 180mg/KgBW/day, for 21 days. All mice were terminated on day 22nd. The p53 and Bcl2 expressions were analyzed using Allred score, statistically analized by Kruskal Wallis followed by Post-Hoc Mann Whitney U test.Results :Immunohistochemistry staining shows the p53 expressions have been increased between groups, but Bcl2 were decreased. The Kruskal-Wallis and Post-Hoc Mann Whitney U test are significantly difference between groups.Conclusion :All of the p53 and Bcl2 expressions between groups are significantly differences.
The Effects of Rusip on the Amount of Lactic Acid Bacteria in Gastrointestinal Tract
Authors: Efrizal Wiwin , Wahyono Hendro , Johan Andrew
Published: July 2018

ABSTRACTBackground : Rusip consumption can change the microbial composition of the digestive system. Microbial changes due to rusip consumption that is measured by lactic acid bacteria count has not been conducted.Objective : The purpose of the study was to analyze the effect of rusip consumption to the number of lactic acid bacteria in the gastrointestinal tract.Methods : Experimental study with post test only control group design using twelve Rattus novergicus Sprague dawley strains aged 2-2.5 months which were divided into 2 groups. Rats adapted for a week, then they were given rusip 5.1 mg/g body weight for 14 days. Cecal content were taken on the 22th day to be analysed for the lactic acid bacteria count.Results : The number of lactic acid bacteria (LAB) in the group given rusip was lower compared to the control group, but not significantly different (p=0.180). Weight gain was greater in the treatment group compared to the control group. The given group tends to have more weight in cecal content and lower pH compared to the control group.Conclusion : Rusip consumption does not increase the number of lactic acid bacteria in gastrointestinal tract.  Keywords : Rusip, cecum, fermentation, lactic acid bacteria, gastrointestinal tract
The global impact of the International Federation of Clinical Chemistry and Laboratory Medicine, Education and Management Division: engaging stakeholders and assessing HbA1c quality in a multicentre study across China
Authors: English Emma , Weykamp Cas , Ji Linong , Siebelder Carla , Shan Zhongyan , Wang Yufei , Li Huijun , Garry John W.
Published: July 2018

Background

Diabetes mellitus is a major global issue and high quality testing is essential for the diagnosis and treatment of the disease. The IFCC Committee for the Education in the Utility of Biomarkers in Diabetes (C-EUBD) plays a global role in improving knowledge and understanding around diabetes testing. This paper describes a multi-stakeholder approach, to improving diagnostic and therapeutic testing for diabetes, using a multicentre study in China as an example of the global impact of the group.

Methods

Educational workshops were developed to support the scientific aims of the study in which 30 centres around China received identical, fresh frozen whole blood samples with values assigned using IFCC secondary reference methods and undertook precision (EP-5) and trueness studies. Performance was assessed using sigma metrics.

Results

A successful multi-stakeholder group was developed and sustained throughout the study through several educational workshops, which enabled the formation of a long-term collaboration with key opinion leaders and policy makers in China. All 30 centres showed good performance with within and between laboratory coefficient of variations (CVs) below 3% in SI units at both low and high haemoglobin A1c (HbA1c) levels. All individual laboratories met the criteria of a sigma of two or more at a total allowable error (TAE) of 5 mmol/mol (0.46% NGSP).

Conclusions

The study led to a successful multi-partner approach to improving diabetes testing in China. All centres involved in the study meeting the published IFCC quality criteria, paving the way for future clinical trials and an expanded role for HbA1c testing across the country.
Differential Change of Borderline Personality Disorder Traits During Dialectical Behavior Therapy for Adolescents
Authors: Buerger Arne , Fischer-Waldschmidt Gloria , Hammerle Florian , Auer Kristin von , Parzer Peter , Kaess Michael
Published: July 2018

Despite the expansion of treatment options for adults with borderline personality disorder (BPD), research on treatment options for adolescent BPD is scarce. The aim of this study was to investigate the impact of dialectical behavior therapy for adolescents (DBT-A) on the individual trait level as primary outcome; and the frequency of suicide attempts and nonsuicidal self-injury, self-reported BPD core pathology, and general psychopathology as secondary outcomes. Seventy-two adolescents (aged 12–17 years) with full- or subsyndromal BPD were treated with DBT-A (25 single sessions, 20 sessions of skills training), and 13 patients (18.1%) withdrew during treatment. From baseline to post-treatment, the number of BPD traits decreased significantly (p ≤ .001). All secondary outcomes decreased significantly as well (p ≤ .001). Results of this uncontrolled study suggest that beside self-harm, DBT-A may also have a beneficial impact on other features of BPD.
Effects of a Painful Stimulus on Stress Regulation in Male Patients With Borderline Personality Disorder: A Pilot Study
Authors: Naoum Janina , Kleindienst Nikolaus , Baumgärtner Ulf , Willis Franziska , Mancke Falk , Treede Rolf-Detlef , Bohus Martin , Schmahl Christian
Published: July 2018

Pain processing in relation to stress has so far not been investigated in male patients with borderline personality disorder (BPD). This experimental pilot study examined 17 male BPD patients and 20 male healthy controls (HCs) to assess the effects of a pain stimulus on arousal, aggression, pain (ratings), and heart rate. At baseline, BPD patients showed significantly higher arousal and aggression; however, there was no significant difference in heart rate compared to the HC group. Following stress induction, a noninvasive mechanical pain stimulus was applied. No significant differences in pain ratings or heart rates were found between the groups. For arousal, a significantly stronger decrease was revealed in the BPD group compared to the HC group (t = 2.16, p = .038). Concerning aggression, the BPD group showed a significantly greater decrease after the pain stimulus than the HC group (t = 3.25, p = .002). This data showed that nonsuicidal self-injury can reduce arousal and aggression in male BPD.
Distintas familias, distintos consumos: relación de las dinámicas familiares con el consumo de alcohol en adolescentes en Colombia
Authors: Mejía-Trujillo Juliana
Published: July 2018

La mayoría de estudios sobre consumo de alcohol en adolescentesse limita a la presentación de estadísticas sobre prevalencias. Este estudio se centra en las dimensiones cualitativas del problema, por medio de la realización de diez grupos focales; cinco con padres de familia y cinco con adolescentes, con un total de 116 personas. Se llevaron a cabo en Bogotá, Barranquilla, Bucaramanga, Cali y Medellín. Los resultados muestran que el consumo de alcohol en menores de edad es un hecho normalizado por la cultura; que los primeros consumos casi siempre ocurren en reuniones familiares; que las dinámicas en las familias relacionadas con normas, límites, autoridad, socialización y relaciones son fundamentales para los adolescentes a la hora de tomar la decisión de ingerir alcohol o no, más que el conocimiento que tienen de los riesgos; y que los programas preventivos deben ir principalmente dirigidos al ámbito familiar, y no tanto a los mismos adolescentes, ya que en muchos casos el consumo es inducido por los miembros mayores de la familia, como abuelos, tíos y, en ocasiones, por los mismos padres.
Estudio de la presencia de la Teología Católica en las Universidades Públicas Españolas en la primera década del siglo XXI.
Authors: González Martín Rafael
Published: July 2018

Como consecuencia de la salida de la teología de las universidades civiles españolas en 1853, los estudios teológicos se vieron refugiados en los seminarios diocesanos alcanzando estos la facultad de otorgar el grado de bachiller, licenciado y doctorado en Teología. La Iglesia española desde 1853 hasta los preludios del Concilio Vaticano II (CV II), vivió de esta estructura. Es a partir del CV.II y de la separación de la religión del carácter oficial del estado, cuando se comienza un nuevo florecimiento y expansión de las facultades y centros de estudios teológicos, desarrollando estos en la primera década del siglo XXI un gran avance investigador del pensamiento teológico, dando lugar a una nueva presencia de la Teología en las Universidades Públicas Españolas. El presente artículo presenta las distintas formas de presencia en el marco de la Universidades Públicas Españolas.
Preparing a two day GIS workshop for Arts and Humanities researchers
Authors: Rivard Joel , Simpkin Sarah
Published: July 2018

In winter 2018, we were approached to lead a two day (12 hour) workshop for arts and humanities researchers as part of the Digital Humanities Summer Institute: Technologies East (DHSITE) conference hosted by the University of Ottawa. The workshop, Introduction to Mapping and Spatial Methods for the Humanities, built upon a shorter offering presented by Sarah last year. It had a Historical GIS (HGIS) twist and was open in terms of datasets, software, and instructional materials.
"Healthy Sexuality": “It’s not gay or bad, it’s SSAD"
Authors: Smilges John
Published: July 2018

Many ex-gays claim to be part of a marginalized group: the disability community. They claim that their homoerotic desires are indicative of mental illness and thus make them disabled. This essay explores the implications of this claimed disability. Given the context of a growing desire for queer-crip coalition work, how does the existence of ex-gays affects our theorization of disability and sexuality, pushing us to be more aware of the messiness of identity politics?
"Healthy Sexuality": Opposing Forces? Autism and Dating, Romance, and Sexuality in the Mainstream Media
Authors: Brooks Emily
Published: July 2018

Autism and romance occupy a space of discomfort in mainstream media conversation. Employing post-structuralist textual analysis, I explore themes arising from mainstream media representations of autism and dating, sexuality, and romance through eleven feature articles from major American newspapers. The United States mainstream media applies a medical model lens to autism, associates immaturity and a lack of empathy with autistic people, and positions autistic sexuality as disruptive and dangerous. Because autistic sexuality representation counters conventional concepts of romance, autism and romance are positioned as opposing forces. The mainstream media portrays autistic people who date through supercrip narratives. Rather than showing the vast diversity of autism communities, mainstream news articles present autistic people through a heterosexualized, gendered, and whitewashed lens. As a disability studies scholar and autistic writer, I advocate for mainstream news coverage that takes a social model approach to autism, incorporates multiple identities, and provides accurate reflections of autistic people as loving adults, as well as disability rights activism that addresses underlying sexual ableism in American society.
Bojanov-Naidenov problem for positive (negative) parts of differentiable functions on the real domain
Authors: Kameneva V.V. , Kofanov V.A.
Published: July 2018

We solve the extremal problem $$$\| x^{(k)}_{\pm} \|_{L_p[a,b]} \rightarrow \sup$$$, $$$k = 0, 1, ..., r-1$$$, over the set of pairs $$$(x, I)$$$ of functions $$$x\in W^r_{\infty} (\mathbb{R})$$$ and intervals $$$I = [a,b]$$$ with restrictions on the local norm of function $$$x$$$ and the measure of support $$$\mu \{ \mathrm{supp}_{[a,b]} x^{(k)}_{\pm} \}$$$.
Pointwise estimates of the best one-sided approximations of classes $$$W^r_{\infty}$$$ for $$$0 < r < 1$$$
Authors: Pas'ko A.M. , Stefura V.D.
Published: July 2018

The asymptotic pointwise estimation of the best one-sided approximations to the classes $$$W^r_{\infty}$$$, $$$0 < r < 1$$$, has been established.
The order of the best transfinite interpolation of functions with bounded laplacian with the help of harmonic splines on box partitions
Authors: Skorokhodov D.
Published: July 2018

We show that the error of the best transfinite interpolation of functions with bounded laplacian with the help of harmonic splines on box partitions comprising $$$N$$$ elements has the order $$$N^{-2}$$$ as $$$N \rightarrow \infty$$$.
Evaluation of turbidity and dissolved organic matter removal through double filtration technology with activated carbon
Authors: Torres-Lozada Patricia , Amezquita-Marroquín Claudia Patricia , Agudelo-Martínez Karen Daniela , Ortiz-Benítez Natalia , Martínez-Ducuara David Santiago
Published: July 2018

La reducción de la calidad fisicoquímica y microbiológica de las fuentes superficiales de suministro para consumo humano, requiere utilizar tratamientos complementarios para garantizar el suministro de agua segura. En este estudio se evaluó la doble filtración con carbón activado granular (CAG: vegetal- cáscara de coco y mineral-bituminoso), para evaluar la reducción de turbiedad y materia orgánica disuelta (UV254). Se empleó agua filtrada de una Planta de Tratamiento Convencional–PTAP; la segunda filtración se realizó en columnas de laboratorio de flujo continuo a gravedad, con porcentajes CAG:arena 100:0, 80:20, 50:50, 30:70, 0:100. Mientras el filtro de arena fue más eficiente en remoción de turbiedad, las configuraciones con CAG lo fueron en la remoción de UV254, siendo más eficientes los filtros con mayor porcentaje de CAG. Los resultados demuestran que la doble filtración empleando CAG, puede ser una alternativa eficiente para la remoción de materia orgánica y la producción de un agua potable segura.
Integración de herramientas para la toma de decisiones en la congestión vehicular
Authors: Herrera-Herrera Nelson Ivan , Luján-Mora Sergio , Gómez-Torres Estevan Ricardo
Published: July 2018

Este estudio tiene como finalidad presentar un análisis de la utilización e integración de herramientas tecnológicas que ayudan a tomar decisiones en situaciones de congestión vehicular. La ciudad de Quito-Ecuador es considerada como un caso de estudio para el trabajo realizado. La investigación se presenta en función del desarrollo de una aplicación, haciendo uso de herramientas Big Data (Apache Flume, Apache Hadoop, Apache Pig), que permiten el procesamiento de gran cantidad de información que se requiere recolectar, almacenar y procesar. Uno de los aspectos innovadores de la aplicación es el uso de la red social Twitter como fuente de origen de datos. Para esto se utilizó su interfaz de programación de aplicaciones (Application Programming Interface, API), la cual permite tomar datos de esta red social en tiempo real e identificar puntos probables de congestión. Este estudio presenta resultados de pruebas realizadas con la aplicación, durante un período de 9 meses.
The Challenge of Traditional Market Traders in Denpasar City with the Problem of Business Management and Sales Strategy
Authors: Martini Luh Kadek Budi , Astuti Putu Sri , Candra Dewi Luh Komang
Published: July 2018

Challenges by traditional fruit market traders in Denpasar are weaknes in business management, bookkeeping administration sales strategy, buyers service, communication techniques, and rotten fruits that do not sell yet untapped. The purposes of this empowerment are to (1 ) improvement of business management, (2) increased of knowledge for traders: bookkeeping administration is the procedure of recording financial transactions and can easily perform financial analysis, sales strategy, especially arrangement of merchandise (display), service to buyers, communication techniques and transactions honest but still profitable, (3) utilization of rotten fruit that is not sold to be processed into MOL (local microorganisms) for the manufacture of organic fertilizers in the household scale. The method used is counseling and training. The results of the activities are as follows: 1) fruit trader group can already well manage its trading business.2) fruit trader group can make good administration and business bookkeeping 3) fruit trader group can make marketing strategy by arranging (display) with well, and already use Show Case for display merchandise, customer visits increased 25%. 4) Fruit merchant group can already utilize rotten fruit as MOL for liquid crop fertilizer
The Influence of Financial Incentives and Non Financial Incentives to Job Performance: Motivation of Work as A Variable of Modernation in Employee Cooperation of Save Loans (Ksp) Mitra Sari Dana Denpasar Oleh
Authors: Sukanta I Wayan , Yuesti Anik , Kepramareni Putu
Published: July 2018

The purpose of this study is to analyze the influence of financial incentives on job motivation, the influence of non-financial incentives on job motivation, the influence of financial incentives on job performance, the influence of non-financial incentives on job performance, and the influence of work motivation on job  performance in the Cooperative Savings and Loans (KSP) Mitra Sari Dana Denpasar. This research is a quantitative research using primary data obtained from the questionnaire and measured by using Likert scale. The population of this research is employees at Savings and Loans Cooperative (KSP) Mitra Sari Dana Denpasar. The method of selecting the sample of this study using purposive sampling. The sample of this research is all employees who work Cooperative Savings and Loans (KSP) Mitra Sari Dana Denpasar as much as 32 people. Data analysis technique used in this research is Structural Equation Modeling (SEM) based on Partial Least Square (PLS) using SmartPLS 3.0 program.The result of the research shows that (1) financial incentive has positive and significant effect to job motivation, (2) non financial incentive has positive and significant effect to job motivation, (3) financial incentive has positive and significant effect to job performance, (5) the influence of mediation of job motivation variable on indirect influence of financial incentive to job performance is partial, and (7) influence of mediation job motivation variable on the indirect effect of non-financial incentives on job performance is partial
Performance in the Deep Squat Test and the risk of musculoskeletal injuries: a systematic review
Authors: Santos Bunn Priscila Dos
Published: July 2018

Deep Squat Test (DS) is a functional test frequently used in risk classification protocols for musculoskeletal injuries in physical activities. Objective: To systematically evaluate the literature on the validity of DS as a predictor of musculoskeletal injuries. Method: A search without language or time filters was carried out on the Medical Literature Analysis and Retrievel System Online (MEDLINE), Scientific Electronic Library Online (SciELO), Physiotherapy Evidence Database  (PEDro) and Virtual Health Library  (BVS) databases with the following title words: injury prediction, injury risk and deep squat. We included prospective studies of DS as a risk classification test for musculoskeletal injuries during the practice of physical activities until December 2016. The participants' profile, sample size, classification of musculoskeletal injuries, follow-up time, study design and results were extracted from the studies. The bias risk analysis was performed with the Newgate-Ottawa Scale. Results: Five studies were included, using different analyzes, whose results varied. The odds ratio ranged from 1.21 to 2.59 (95% CI = 1.01 - 3.28). The relative risk was 1.68 (95% CI = 1.50 - 1.87), sensitivity from 3 to 24%, specificity from 90 to 99%, PPV from 42 to 63%, NPV from 72 to 75% and AUC from 51 to 58%. Conclusion: DS is a test whose presence of movement dysfunctions is a predictor of the risk of musculoskeletal injuries in individuals who practice physical activities. However, due to the methodological limitations presented, caution is suggested when interpreting such results.
Biomarkers That Predict The Response to Chemo-radiotherapy in Rectal Cancer
Authors: Kim Nam Kyu
Published: July 2018

The treatment of locally advance rectal cancer is a challenging with a relatively high incidence of local recurrence. CRT, however, has proven to be a great success in controlling rectal tumor locally. Nevertheless, recognizing relevant biomarkers are of paramount importance in order to tailor patient management and to avoid unnecessary chemotherapy related morbidity. In addition, biomarkers could outline oncological outcomes early on. Tumor response considered a strong indicator about tumor status and response to the given treatment. Unfortunately, there is no single effective method to predict tumor response to CRT treatment solely. However development of clinical and immunohistochemistry markers are essential to know what it takes to design a proper management plan for the right patient. We focus in our review to summarize relevant articles emphasizing predictive value of tumor biomarker in estimating rectal cancer response to preoperative CRT.
A Scientific Critique of Evolution...The Need For An Alternative (to what is now believed).
Authors: Nigro Samuel A.
Published: July 2018

Everyone has bought into current evolution theories by dogmatic acceptance without usual scientific criticism.  No alternative is offered but the scientific criticisms should be respectfully accepted and answered.
Smartphone and Web 2.0 tools for CPD amongst General Practitioners in Wessex. A qualitative review
Authors: Willman Antony
Published: July 2018

This article was migrated. The article was not marked as recommended. There is increasing ownership of smartphones in the UK. These provide a portable and convenient way to access the Internet and to run a variety of applications. Amongst under- and post-graduate students they are used increasingly for educational purposes. Despite widespread ownership, barriers may exist preventing General Practitioners from using their smartphones for education. This service evaluation confirmed there is high smartphone ownership amongst GPs with a sizeable cohort using them for medical education and CPD. There remains, however, a reluctance to use Web 2.0 tools for CPD.
Celso Furtado: um economista a serviço da gestão pública (1943-1964)
Authors: Tenório Fernando , Wanderley Sergio
Published: July 2018

Resumo O objetivo deste artigo é resgatar na biografia de Celso Furtado sua trajetória como servidor público entre 1943 e 1964. Mais conhecido por suas contribuições para o campo da economia, entretanto, Furtado iniciou sua carreira de funcionário e acadêmico, como pesquisador e professor, no campo da administração pública. Em 1943, Furtado entrou por concurso para o Departamento Administrativo do Serviço Público (Dasp) como assistente de organização e alcançou, 20 anos depois, a posição de ministro de Estado no governo de João Goulart (1961-1964). Durante o período investigado, Furtado trabalhou na Comissão Econômica para a América Latina (Cepal), em Santiago (Chile), entre 1949 e 1957, retornou ao Brasil para se tornar diretor do Banco Nacional de Desenvolvimento Econômico (BNDE), o que o levaria a organizar a Superintendência do Desenvolvimento do Nordeste (Sudene) da qual ele foi o primeiro superintendente. Furtado foi o principal disseminador das ideias da Cepal no Brasil que propunham a centralidade do Estado na promoção do desenvolvimento e a consequente necessidade de um novo perfil de gestor público para gerir esse processo. O período foi marcado pelo diálogo entre desenvolvimento econômico e administração do desenvolvimento, o que levou à tese da vinculação do desenvolvimento econômico ao desenvolvimento da técnica e arte de administração. Destarte, Furtado foi um dos pensadores cuja reflexão teórica e prática ajudou a consolidar as grandes empresas estatais do país. Resgatar a trajetória de Furtado como gestor público propicia uma reflexão ponderada sobre o papel do Estado na economia e sobre o papel do gestor público.
Sustaining Social Protection and Provision: the front line in the battle for the Good Society
Authors: Evans Peter
Published: July 2018

Abstract In an era when social policy priorities are subordinated to regressive capitalist agendas, sustaining collective commitments to social protection and social provision defines the front line of the battle for the good society. The conflict manifests itself across a range of arenas, but health is analytically archetypal. This introductory article for the special issue assumes the dynamics of the contradiction between the inherently collective character of health provision and capitalist insistence on using individual consumption valued in market prices to measure societal success. Left unchecked, the elite bloc whose agenda is defined by pursuit of the interests of capital will destroy existing social provision and protection, making societies, especially in the Global South, ugly places to live for ordinary citizens. The articles in this volume leave us with a challenge: how can we construct the oppositional agency necessary to expand and strengthen social provision and protection in an era of regressive capitalist domination?
Doenças do sistema nervoso central de bezerros no sul do Rio Grande do Sul: uma contribuição ao diagnóstico diferencial
Authors: Santos Bianca L. , Estima-Silva Pablo , Coelho Ana Carolina B. , Oliveira Plinio A. , Soares Mauro P. , Sallis Eliza S.V. , Bruhn Fabio R.P. , Schild Ana Lucia
Published: July 2018

RESUMO: Este estudo teve o objetivo de determinar a frequência das enfermidades do sistema nervoso central que afetam bezerros até 12 meses de idade na região sul do Rio Grande do Sul. Foi realizado um estudo retrospectivo estabelecendo-se as principais enfermidades observadas nesta categoria de bovinos em um período de 36 anos. Foram revisados os protocolos de necropsia e de materiais remetidos ao Laboratório Regional de Diagnóstico da Faculdade de Veterinária da Universidade Federal de Pelotas entre janeiro de 1978 e dezembro de 2015 referentes aos bovinos até 12 meses de idade que apresentavam sinais neurológicos. Foram resgatados os dados epidemiológicos referentes à procedência dos animais, tipo de criação, raça, idade e época de ocorrência e frequência de cada enfermidade. Foram identificados 615 casos de bovinos com sinais neurológicos, dos quais 162 (26,3%) tinham até 12 meses de idade. Os diagnósticos foram agrupados por etiologia, sendo que as enfermidades virais totalizaram 42,6% dos casos; as doenças bacterianas 19,1% e as doenças parasitárias 17,3%. Os defeitos congênitos e as doenças hereditárias representaram 6,2% dos casos, seguidos pelas intoxicações e micotoxicoses com 4,9%; pelas doenças carenciais e multifatoriais ambas com 2,5% dos casos e pelos traumatismos com 1,9%, doenças degenerativas e neoplasias com 0,6% dos diagnósticos. Os casos inconclusivos representaram 1,86% do total. Nos bezerros até os 90 dias as principais enfermidades foram os defeitos congênitos e as meningites e encefalites por causas bacterianas, além dos abscessos do sistema nervoso central; nos bezerros entre os quatro e nove meses as enfermidades tiveram uma frequência mais baixa destacando-se apenas a raiva. A partir dos 10 até os 12 meses a babesiose, a raiva e a encefalite por herpesvírus bovino foram as mais importantes como causa de morte.
Determinação das forças de vínculo em sistemas clássicos holônomos: análise crítica de três métodos
Authors: Lima Wellisson Pires , Oliveira Pedro Henrique Ferreira de , Braga João Philipe Macedo , Ramos Igor Rochaid Oliveira
Published: July 2018

Resumo Nesse trabalho, analisamos de maneira crítica as peculiaridades e potencialidades de três abordagens para o cálculo das forças de vínculo em sistemas clássicos holônomos, a saber, o formalismo Newtoniano, o formalismo Lagraniano e um terceiro método misto desenvolvido pelo físico brasileiro Nivaldo A. Lemos [1]. Analisando as soluções de três problemas clássicos por cada um desses métodos, concluímos que o número de dimensões e a quantidade de vínculos do problema influem sobre a eficiência dos métodos, o que proporcionou o estabelecimento de um critério para a escolha do formalismo a ser utilizado.
Integração de instituições de ensino superior com sistemas municipais de saúde à luz de uma tipologia da colaboração interprofissional
Authors: Barreto Ivana Cristina de Holanda Cunha , Ribeiro Kelen Gomes , Moreira Ana Ester Maria Melo , Goya Neusa , Dias Maria Socorro de Araújo , Andrade Luiz Odorico Monteiro de
Published: July 2018

O objetivo deste estudo foi investigar o processo de colaboração interprofissional entre os diretores, docentes de instituições de ensino superior (IES), gestores dos Sistemas Municipais de Saúde e profissionais da Estratégia de Saúde da Família de duas cidades estratégicas para expansão do ensino superior em saúde no Ceará. Tratou-se de estudo analítico de casos múltiplos. Foram utilizadas pesquisa documental e entrevistas semi-estruturadas com 75 gestores e profissionais da saúde, diretores e docentes de IES. O corpus de dados foi submetido à análise temática ancorada em uma Tipologia da Colaboração Interprofissional. Os resultados evidenciam que, em Sobral, a colaboração entre os atores mencionados encontra-se em desenvolvimento, enquanto em Juazeiro do Norte está incipiente. Os elementos facilitadores foram a clareza dos benefícios da integração para a qualidade da atenção e a formação profissional, a institucionalização e a gestão participativa do processo.
A Educação Interprofissional e a prática compartilhada em programas de residência multiprofissional em Saúde
Authors: Casanova Isis Alexandrina , Batista Nildo Alves , Moreno Lídia Ruiz
Published: July 2018

O artigo tem por objetivo analisar os princípios, concepções e práticas da Educação Interprofissional, com ênfase na prática compartilhada em programas de residência multiprofissional em Saúde (PRMS) nas instituições de ensino superior (IES) do Estado de São Paulo, Brasil. Foi realizada análise documental dos projetos pedagógicos (PP), aplicação de instrumento tipo Likert e perguntas abertas a 76 residentes de 13 PRMS. A análise temática dos PP mostra ênfase na responsabilização da equipe perante os casos clínicos e planos de cuidado; centralização nas necessidades do paciente e articulação entre ensino-serviço. Os resultados do instrumento Likert evidenciam satisfação dos residentes com a formação para prática colaborativa. Na perspectiva dos residentes, os PRMS ampliam e melhoram os resultados em saúde, favorecem a atuação centrada no paciente, a identificação das necessidades de saúde e o compartilhamento de práticas e procedimentos. Dessa maneira, os PRMS são importantes no cenário de consolidação do Sistema Único de Saúde (SUS).
Measuring success in post-conflict infrastructure development
Authors: Hay Alexander H. , Kilburn Rory G.
Published: July 2018

Infrastructure reconstruction and development facilitates the transition of post-conflict economies to socio-economic stability and financial normalcy. The current system of measuring success is output-based and not a reliable indicator of outcome. Furthermore, standardised output metrics are easily and often abused. However, the outcome of any infrastructure project is by definition retrospective. The post-conflict context makes this particularly complicated. A direct retrospective measure of outcome is impractical, yet any situation-specific outcome-based metric must be current and relevant during construction to be practicable. Causal-chain-derived indicators of likely outcome provide a more relevant metric; the more indicators that point to a common outcome, the greater the confidence of that outcome being realised. This paper discusses an outcome-based causal chain approach to identifying indicator metrics.
Biyogübre uygulamasının Cupressus arizonica ve Acer saccharum L. fidanlarının bazı morfolojik özelliklerine etkisi
Authors: Parlak Salih , Yılmaz Mustafa , Özgün Orkun
Published: July 2018

Son yıllarda mineral gübreler yanında, besinlerin alımını sağlayan farklı bakteri türlerinin saf veya karışımlarını ihtiva eden biyogübreler kullanılmaya başlanmıştır. Tarımda yaygın olarak kullanılmasına rağmen biyogübrelerin orman fidanlıklarında kullanımı göreceli olarak yeni bir uygulamadır ve orman fidanlarının morfolojik karakterlerine etkileri konusunda yapılmış çalışmalar sınırlıdır. Bu çalışma, biyogübrelerin dış ortam şartlarında fidan yastıklarına uygulandığında fidan morfolojik karakterlerine etkilerinin belirlenmesi için gerçekleştirilmiştir. Çalışmada Bursa Orman Fidanlığında yastıkta yetiştirilen 1+0 yaşlı mavi servi (Cupressus arizonica) ve şeker akçaağacı (Acer saccharum) fidanları kullanılmıştır. Çok sayıda ticari biyogübre içinden, bileşimleri farklı bakterileri ihtiva eden iki farklı biyogübre çeşidi (Best-doll ve Bio-doll) seçilerek dört farklı doz (3 ml/l, 15ml/l, 30 ml/l ve kontrol) uygulaması yapılmış, bazı fidan morfolojik karakterlerine etkileri araştırılmıştır. C. arizonica ve A. saccharum fidanlarına uygulanan değişik biyogübreler ve dozları fidan boyu, kök boğaz çapı gibi bazı fidan morfolojik karakterlerinde anlamlı (belirgin) fark oluşturmuştur. A. saccharum fidanlarında Best-doll ve Bio-doll biyogübrelerinin 3 ml/l dozları kontrole göre fidan boyunu sırasıyla % 13 ve % 11, kök boğaz çapını ise sırasıyla % 13 ve % 16 artırmıştır. C. arizonica’nın ise kontrol grubu fidanları, her iki biyogübre uygulaması yapılan fidanlardan daha yüksek boy ve çap artımı sağlamıştır. Çalışmalara; birden fazla doz uygulama, farklı tür ve toprak şartlarında kullanım ve kimyasal gübrelerle kombine uygulamalar gibi konularda devam edilmelidir.
Memory and attention deficit in chronic migraine
Authors: Latysheva N. V. , Filatova E. G. , Osipova D. V.
Published: July 2018

Background. Memory and attention deficits are prevalent in the chronic pain population. There are multiple common mechanisms in chronic pain and cognitive impairment. However, the presence, prevalence and clinical burden of such impairment are frequently underestimated.

Objective: to evaluate subjective and objective cognitive deficits in patients with chronic migraine (CM).

Materials and methods. We recruited 53 subjects with CM and 22 genderand age-matched controls with low-frequency episodic migraine (a maximum of 4 headache days per month) aged 18–59. All patients filled in the HADS (Hospital Anxiety and Depression Scale) anxiety and depression scale and Pittsburg Sleep Quality Inventory (PSQI). Cognitive function was assessed with Montreal Cognitive Assessment (MoCA), Digital Symbol Substitution Test (DSST), Rey Auditory Verbal Learning Test (RAVLT) and the Perceived Deficits Questionnaire (PDQ-20).

Results. 56 % of patients with CM complained of memory problems. Decreased cognitive function was also observed during self-assessment using the PDQ-20 questionnaire. Objectively, we found a significant decrease in 90-second DSST results and RAVLT total recall and learning rates. 44 % of subjects with CM scored lower than 26 points on MoCA. Most frequently we found impairments in attention (75 %), memory/delayed recall (50 %), language (50 %) and executive function (37 %). Depression and sleep quality correlated with only several parameters of cognitive tests.

Conclusion. Subjective and objective cognitive deficits are prevalent in the CM population. Most often memory and attention are impaired. Cognitive complaints need to be carefully assessed, and treatment of such impairment may improve quality of life and decrease disability in CM.
Spinal muscular atrophy with lower limbs phenotype: clinical and genetic description of novel mutation in the DYNC1H1 gene
Authors: Dadali E. L. , Nikitin S. S. , Konovalov F. A. , Akimova I. A. , Korostelev S. A.
Published: July 2018

Background. Spinal muscle atrophies (SMA) are a group of diverse heterogenous diseases caused by mutations in several dozens of genes. A rare form of autosomal dominant SMA predominantly affects muscles of the lower extremities.

The study objective is to describe clinical and genetic characteristics of Russia-living patients with SMA predominantly affecting muscles of the lower extremities caused by the DYNC1H1 gene mutation discovered by next-generation exome sequencing.

Materials and methods. To diagnose the syndrome a complex of examination techniques was used: genealogical analysis, neurological examination, electromyography, and DNA diagnostics. Changes in the nucleotide sequence in the probands and their parents identified with massive parallel sequencing were studied using direct automatic sequencing with oligonucleotide primers.

Results. Five (5) patients from 4 families with heterozygous mutations in the DYNC1H1 gene were identified. In the patients, one type of SMA predominantly affecting the lower extremities was assumed. Prior to exome sequencing, all patients were monitored for myelodysplasia diagnosis, and magnetic resonance imaging of the spine has showed protrusions and/or spondylolisthesis of the lumbar spine in 4 of the patients. The obtained results can demonstrate both hyperdiagnosis and that spinal pathology is one of the characteristic symptoms of SMA predominantly affecting the lower extremities.

Conclusion. The obtained results allow to make an assumption about a wide range of clinical polymorphisms in patients with mutations of the DYNC1H1 gene. Apart from typical clinical manifestations of SMA predominantly affecting the lower extremities, patients can be diagnosed with hereditary motor and sensory neuropathy 2, myelodysplasia, and congenital arthrogryposis which has to be taken into account during diagnostic search.
Prospective clinical and sonographic observation of the patient with hourglass-like focal radial nerve constriction
Authors: Druzhinin D. S. , Naumova E. S. , Nikitin S. S.
Published: July 2018

This prospective clinical and sonographic observation of the 29 y.o. woman with acute neuropathic pain along the course of the radial nerve, who was later diagnosed with hourglass-like focal radial nerve constriction at the level of the inner fold of the elbow. Dynamic observation was carried out at the level of the most severe pain (at the inner fold of the elbow), starting from the 3rd day after onset of symptoms and within 15 months. At the time of patient’s admission pain syndrome and paresis of extensor muscles of the hand and fingers were significantly pronounced, but we didn’t detect any sonographic changes of the radial nerve. During dynamic observation the segment of focal peripheral nerve constriction has been detected on the 30th day of observation and the portion of multisegmental constriction on the 57th day of observation, but the observed changes did not correlate with the rate of neurologic deficit restoration. On the scans of the radial nerve obtained 9 and 15 months after disease onset the uniform decrease in the nerve diameter was evident, which made it impossible to visualize focal peripheral nerve constriction.
A case of hereditary motor and sensory neuropathy type IVA with unusual genealogy
Authors: Kurbatov S. A. , Milovidova T. B. , Fedotov V. P. , Murtazina A. F. , Rudenskaya G. E. , Shchagina O. A. , Polyakov A. V.
Published: July 2018

Background. Hereditary motor and sensory neuropathies (HMSN) are a genetically diverse group of disorders of the peripheral nerves characterized by gradual development of weakness, muscular hypo-/atrophy, sensory disturbances in distal areas of the extremities. Currently among the recessive forms, the most prevalent HMSN is associated with the ganglioside-induced differentiation associated-protein 1 (GDAP1) gene (GDAP1-HMSN).

The objective is to present an observation of a family case of HMSN type IVA with unusual genealogy.

Materials and methods. Clinical, electrophysiological, and genetic characteristics of a Russian family with GDAP1-HMSN were examined.

Results. We describe a family with autosomal recessive HMSN and unusual genealogy due to homozygous and compound heterozygous mutations of GDAP1.

Conclusion. The particularity of the described family case is the unusual genealogy with the patients in two non-consecutive generations. This type of inheritance is caused by presence of mutations in compound heterozygous state in the proband's grandson which was confirmed by genetic analysis. The presented case demonstrates the importance and necessity of full analysis of the GDAP1 gene or identification of 2 mutations in trans-position in the proband and subsequent assessment of possible risks for future generations. Multiple stroke-like episodes in the 2 affected members of the family are described that have not been previously reported for GDAP1-HMSN. Stroke has been presented in HMSN associated with mitofusin-2 gene which also as GDAP1, affects mitochondrial function in the neurons.
Children juries in Dagestan
Authors: Daudova Rabiat D. , Bogatyreva Elena M.
Published: July 2018

The aim of this work is to study the peculiarities of children’s injuries in Dagestan.

Methods. We analyzed the data of the State institution of the Republic of Dagestan Republican Medical Information and Analytical Center and the data of statistical reports of the Department of traumatology of the Republican Children’s clinical hospital named after N.M. Kuraev of the Makhachkala city. Various aspects of child’s injuries had been studied within the 2012-2015 years, taking into account the cause, age, sex, type of injury.

Results. The injury frequency takes up the 3rd place in the structure of Dagestan population’ mortality. The numbers of injuries increase as the age of children increase. The greatest number of injuries are among teenage age children that makes 47.7% from the total number of children who applied to the Department of traumatology. Street injuries are prevalent in summer, and it is 67% of all types of injuries at this time of year. The pattern of domestic injuries in Dagestan is not evenly distributed across the time of year. Most injuries occur in winter – 31% and in spring – 28%. Boys are twice as likely to be involved in accidents (68%) as girls (32%). The data obtained allow us to work out recommendations for the prevention of child’s injuries in Dagestan.

Conclusions. The predominant types of child’s injuries in Dagestan are street and household. Bruises and fractures, as well as wounds sharp, piercing, cutting objects are in the first place among children’s injuries.
Clinical and economic efficiency of treatment in patients with tuberculosis in conditions of day hospital
Authors: Shurygin A. A. , Makarova E. A. , Matasova E. V.
Published: July 2018

Aim. To study the clinical and economic efficiency of treatment in patients with tuberculosis in conditions of day hospital when compared with treatment of patients in conditions of 24-hour hospital.

Materials and methods. The results of treatment of patients with first-ever lung tuberculosis in conditions of day hospital were analyzed.

Results. 76.7 % of patients, by the moment of discharge from the hospital, successfully completed the course of treatment.

Conclusions. Clinical efficiency of treatment in the day hospital did not differ from specialized indices of antituberculous work that confirms its significant economic efficiency.
Analysis of activity of prenatal diagnosis service in Perm krai
Authors: Olina A. A. , Sadykova G. K. , Shirinkina E. V.
Published: July 2018

Aim. To analyze the work of prenatal diagnosis im Perm and Perm Krai for the period of 2012–2016.

Materials and methods. Statistical forms 32 for Perm and Perm Krai (PK) over the period of 2012–2016 were analyzed.

Results. During 2012–2016, in Perm Krai there was observed decrease in the absolute number of women with completed pregnancy by 6.3 %, whereas in the city of Perm this index raised by 1.8 %. Positive dynamics concerning complex screening coverage during the first trimester was detected. Calculation of index from the number of women with completed pregnancy in Perm Krai demonstrated a basic rate of growth 63.6 %, in Perm – 77.2 %. The analyzed absolute and relative indices showed increase in the number of the revealed CM in Perm Krai and Perm by 80 %.

Conclusions. Centralization of prenatal diagnosis in Perm and Perm Krai permitted to improve preventive measures for detecting congenital malformations in the early terms of pregnancy.
STK’LARDA STRATEJİLER VE TEMEL KRİTERLER: İZMİR İLİNDE BİR ARAŞTIRMA
Authors: KÖSTEPEN Ali , ÖZMUTAF Nezih Metin
Published: July 2018

Sivil toplum kuruluşları baskı unsuru olarak son yıllarda ciddi bir önem kazanmıştır. Günümüzde sivil toplum kuruluşlarının (STK) yönetim yaklaşımlarından git gide daha fazla faydalandıkları ifade edilebilecektir. Bu STK’ların doğasıyla bütünleştiğinde ise başarılı sonuşların ortaya çıkabileceği belirtilebilecektir. Bu kapsamda çalışmanın amacı, sürece katkı sağlaması açısından STK’larda stratejilerin belirlenmesinde temel kriterlere yönelik üye (yönetici ve yönetici olmayan) algılarının belirlenmesi olarak ortaya konulmuştur. Hazırlanan anket formu Ocak 2018-Mart 2018 tarihleri arasında İzmir ilinde 96 STK kapsamında 127 STK üyesine uygulanmıştır. STK’larda stratejik boyut ve gönüllülük boyutu ve içerdikleri önermeler temel kriterler olarak önemsenmektedir. İki boyut arasında pozitif yönde yüksek bir ilişki vardır. Analiz sonuçlarına göre STK’larda stratejiler ya da stratejik yönetim süreci gönüllülükten yüksek düzeyde etkilenecektir. Ancak katılımcılar Türkiye’deki STK’larda yönetsel süreçlerde stratejik yaklaşım düzeyinin çok yetersiz olduğu algısına sahiptirler.
EVALUATION OF THE REGIONAL EFFECTS FROM REALIZATION OF INVESTMENT PROJECTS IN THE CIRCUMPOLAR ZONE
Authors: Arkhipova K. N.
Published: July 2018

Purpose: the aim of the thesis – analyze the development of the oil and gas sector of the Yamal-Nenets Autonomous District and assess the influence exerted by them on the socio-economic and environmental dynamics of the region.

Methods:the methodological foundations of the research are based on modeling scenarios, analysis of open statistical sources, projected estimates and calculations, projected methods. As open statistical sources were used the data of the official statistics, analytical materials of international organizations, federal and regional authorities.

Results:the main result of the research is the author's methodology for assessing regional effects arising from the implementation of investment projects. Based on the created methodology, regional effects resulting from the implementation of investment projects in the Yamal-Nenets Autonomous District were identified, according to the analysis of which developed recommendations to strengthen their localization in the region.

Conclusions and Relevance:during the analyzed period the carried out calculations of regional effects showed that the positive direct effects emerge in the economic sector only while indirect ones are too weak in the Yamal-Nenets Autonomous District. In these conditions, the regional authorities face the problem to strengthen the localization of direct and indirect effects in the region, because the investment projects can be a locomotive for the development of the region’s prosperity.