bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Chitosan and Silver Nanoparticles Laden with Antibiotics on Multidrug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii
Authors: Madhi Masoumeh , Hasani Alka , Shahbazi Mojarrad Javid , Ahangarzadeh Rezaee Mohammad , Zarrini Gholamreza , Davaran soodabeh , Alizadeh Effat , Sheikhalizadeh Vajihe
Published: December 2024

Background: The emergence of multidrug-resistant (MDR) Pseudomonas aeruginosa and Acinetobacter baumannii is a profound therapeutic concern requiring innovative antimicrobials. Nanotechnology has unlocked new promises, and nanoparticles (NPs) have been used either alone or in combinations against MDR bacteria to overcome antibacterial resistance. Objectives: We aimed to evaluate the antibacterial activity of silver and chitosan nanoparticles alone and in combination with either ciprofloxacin or gentamicin against A. baumannii and P. aeruginosa strains. Methods: The antibacterial activities of synthesized materials were evaluated using microdilution broth, disc diffusion, and drop diffusion methods and the expression of target genes by the quantitative real-time polymerase chain reaction. Results: The result of disc diffusion and drop diffusion methods for chitosan when assessed against MDR or wild type P. aeruginosa and MDR A. baumannii at different concentrations ranged from 8 - 35 mm and 6 - 15 mm respectively, while the range was lower in the nanoparticle form of chitosan. The results also showed that the expression of efflux pump adeB in A. baumannii and mexB in P. aeruginosa decreased after treatment with chitosan, chitosan nanoparticles, and silver nanoparticles; thus, they may be good candidates as efflux pump inhibitors. Conclusions: The present study showed the superiority of antibacterial and anti-efflux pump activity of chitosan over silver nanoparticles against MDR P. aeruginosa and A. baumannii.
The Effect of Anti-Gravity Treadmill on Balance in Acute Phase of Post-Operative Knee Rehabilitation
Authors: Emoto Gen , Sueyoshi Ted
Published: December 2024

Background: An anti-gravity treadmill has been used in orthopedic and neurological rehabilitation. However, little literature on its use in post-operative knee rehabilitation is available. Objectives: The purpose of this investigation was to study an effect of anti-gravity treadmill on balance in an early phase of post-operative knee rehabilitation. Methods: Forty-nine patients who underwent knee surgery participated in this study (study design: cohort study; level of evidence: level II). At one week post-operatively, each patient was tested for timed single leg stance (SLS) on surgical knee on a floor. Patients were placed onto either AlterG group (AG) or control group (CG) after the test based on their pain level. The patients in AG underwent a balance exercise on AlterG, with the pressure adjusted to a pain-free or minimal pain level, once a day at least 5 days a week. Those in CG underwent their balance exercise on a floor in the same manner. All patients were tested again for SLS at 2 week post-operatively. The lengths of SLS were recorded and analyzed. Results: The lengths of SLS were 38.8 seconds and 19.9 seconds for CG and AG, respectively, at 1 week post-operatively. They improved to 50.5 seconds (CG) and 35.0 seconds (AG) at 2 week post-operatively. There was statistically significant between-group difference at both 1 week and 2 week post-operatively. However, there was no significant between-group difference in improvement from week 1 to week 2. Conclusions: A use of anti-gravity treadmill may have a positive effect on balance in an acute phase of post-operative knee recovery in patients who had an increased level of pain during full weight-bearing immediately after knee operation.
Evaluation of Parental Stress and Quality of Life Among Iranian Parents of Hearing-Impaired Children with Cochlear Implantation History: A Cross-sectional and Descriptive-Correlational Study
Authors: Hakimzadeh Atena , Mousavizadeh Seyedeh Narjes , Shafighi Amirhossein , Javaheri Tehrani Fereshteh
Published: December 2024

Background: Hearing impairment (HI), as the most prevalent sensorineural impairment, can affect both children and their families' quality of life (QOL) by its remarkable consequences, like parental stress (PS). It is a type of stress that parents perceive following their parent-child interactions, alongside the children's mental, physical, or developmental disturbances. Objectives: Considering the significant catastrophic consequences of HI in both children and their families' QOL, the current cross-sectional and descriptive-correlational study was conducted to investigate the relationship between PS and QOL among Iranian parents of hearing-impaired children with cochlear implantation (CI) history. Methods: A total of 80 parents of HI children with CI history participated in the current cross-sectional and descriptive-correlational study based on the inclusion criteria and simple random sampling. Therefore, their PS and QOL were evaluated using the "Questionnaire of Clinical and Demographic Information", the "Parenting Stress Index, Fourth Edition Short Form (PSI-4-SF)," and the "36-Item Short Form Survey (SF-36)." Eventually, SPSS version 26 was utilized to analyze the obtained data. Results: Most of the 80 participants were female (85.0%), housewives (58.8%), and had bachelor's degrees (35.0%). Moreover, PS and QOL in parents of HI children with CI history were relatively low (X- = 67.42, P < 0.05) and relatively satisfactory (X- = 70.12, P < 0.05) respectively. Eventually, there was a significant (P = 0.001) and inverse correlation (r = -0.811) between PS and QOL in parents of HI children with CI history. Conclusions: The level of PS in the parents of HI children with CI history had a strong and inverse correlation with their QOL. Also, at the time of the study, the stress level of the parents was relatively low, and their QOL was reported to be relatively satisfactory. Thus, examining the factors affecting PS and QOL will be effective in achieving permanent, stable outcomes.
The Effects of Memantine on the Glasgow Coma Scale, Sequential Organ Failure Assessment Score, and Neuron-Specific Enolase Serum Levels in Traumatic Brain Injury Patients
Authors: Ramezani Ahmad , Ala Shahram , Ehteshami Saeed , Heydari Fatemeh , Salehifar Ebrahim , Shafizad Misagh , Hadadi Kaveh , Abediankenari Saeid , Moosazadeh Mahmood
Published: December 2024

Background: Traumatic brain injury (TBI) causes disability and death in many patients. Objectives: We investigated the effect of memantine on the Glasgow Coma Scale (GCS), serum levels of neuron-specific enolase (NSE), and its effect on sequential organ failure assessment (SOFA) score in TBI patients with GCS 6-12 on days 1, 3, and 7. Methods: Fifty-nine patients were randomly divided into intervention (n = 29) and control (n = 30) groups who received 30mg drug/placebo every 12 hours for seven days with standard treatment, respectively. The acute physiology and chronic health evaluation II and head CT scan findings were collected on the first day, and the Glasgow Outcome Scale Extended 90 was collected three months later. Results: Considering patients with GCS 6 - 12, the SOFA and NSE decreased from day 1 - 7 in both memantine and control groups, about NSE by 21% and 12.6%, respectively. In GCS6-8 subgroup, the NSE decreased by 19.1% in the memantine group and increased by 8.45%, in the control group. In GCS 9 - 12 subgroup, the NSE decreased by 52.6% and 24.43% in the memantine and control groups, respectively. The SOFA changes were significant between memantine and control groups on day 3 in GCS 9 - 12 subgroup (P = 0.01). In the memantine group with GCS 6 - 12, the increase of GCS from day 1 - 7 was significant (29.6%, P = 0.002), and also in both GCS subgroups. Comparing memantine and control groups, the improvement of GCS was significant on days 3 and 7 in GCS 9 - 12 subgroup. Conclusions: This trial showed that memantine improved the neurohormonal and clinical status of TBI patients with GCS 6 - 12.
Missed Nursing Care During the COVID-19 Pandemic in Educational and Medical Centers in Northern Iran: A Cross-sectional Study
Authors: Mehrabian Fardin , Javadi-Pashaki Nazila , Ashouri Asieh , Fakhr-Mousavi Aboozar
Published: December 2024

Background: Nurses are the first point of contact in hospitals and play a significant role in providing high-quality care. Missed nursing care has been shown to be associated with poorer patient outcomes, increased mortality, medication errors, falls, and hospital-acquired infections. Objectives: This study aimed to investigate missed nursing care and its causes and related factors in the north of Iran. Methods: This cross-sectional study was conducted during the COVID-19 pandemic in Rasht, Iran, from January to March 2021. A total of 326 nurses from non-emergency wards of 7 medical centers were enrolled using a simple random sampling method. The data on demographic characteristics, occupational stress (using the expanded nursing stress scale [ENSS]), and missed nursing care and its causes (using the MISSCARE questionnaire) were collected. Data were analyzed by descriptive statistics and multiple logistic regression analyses. Results: Sixty-nine percent of nurses reported that at least 1 aspect of nursing care was missed occasionally, often, or frequently. Also, the median number of missed care items reported on each shift was 4 out of 25. Attending interdisciplinary care conferences (46%), interventions for basic care (45%), and psychological supports for patients (42%) were the most omitted items. The most stated reason was human resources (53%). Also, the occurrence of occasionally, often, or frequently missed care was significantly related to a higher level of nursing occupational stress (adjusted odds ratio [OR], 2.12; 95% CI, 1.28 - 3.52; P < 0.001) and rotating shift work compared to day shift work (adjusted OR, 4.54; 95% CI, 2.38-9.10; P = 0.003). Conclusions: Nursing missed care is relatively prevalent in the north of Iran. Human resources, work shift schedules, and occupational stress play an important role in missed nursing care during the COVID-19 pandemic. It is necessary for policymakers and nursing managers to use strategies to optimize manpower and equipment, develop a standard work shift, and reduce stress in the workplace to improve the quality of patient care.
Effect of Renal Transplantation on Health-Related Quality of Life in Patients with End-Stage Renal Disease; A Quasi-Experimental Study
Authors: Mousavi-Roknabadi Razieh Sadat , Ershadi Faeze , Hadi Negin , Roozbeh Shahroodi Jamshid , Shayan Zahra , Keshavarz Soheila , Raeisi Sarbizhan Halimeh , Roozrokh Afsaneh
Published: December 2024

Background: Renal transplantation is one of the best modalities to lengthen the life expectancy of patients with end-stage renal disease (ESRD). However, no sufficient documents exist regarding the effects of renal transplantation on the health-related quality of life (HRQOL) especially in Iranian population. Objectives: This study aimed to determine the possible influence of renal transplantation in different scales of HRQOL in southern Iran. Methods: This Quasi-experimental study was carried out with 120 patient candidate for renal transplantation (Apr 2012 - Jan 2014). Using the general SF-36 questionnaire, HRQOL of the patients 1 week before and 3 months after the transplantation was evaluated. All data were analyzed statistically using descriptive and analytical tests (α = 0.05). Results: Seventy-eight patients (65%) were male. The mean (SD) of the age was 38.92 (13.259) years. HRQOL and its eight scales were significantly different before and after the transplantation (P < 0.001). There was a significant difference between general perception of health and primary school, as well as diploma (P = 0.008). Other demographical factors such as age, gender, marital status and type of donor had no impact on HRQOL, statistically. There was no correlation between HRQOL and the length of facing the disease, except in the subgroup of role limitation due to physical problems (P = 0.01). Conclusions: The study showed that renal transplantation has sufficient credibility in improvement of HRQOL in patients with ESRD. Moreover, continuous enhancement of education level and public knowledge might be as effective as development of medical serving systems in maintaining and achieving greater improvement in HRQOL.
Health-Related Quality of Life Associated Factors in Breast Cancer Patients in 2017-2018
Authors: Tahmasebi-Ghorrabi Ahmad , Mosavi Seydeh Maryam , Torabipour Amin
Published: December 2024

Background: Breast cancer (BC) is the most commonly diagnosed cancer affecting women's quality of life (QoL) in many ways. Identifying QoL-related factors in these patients can help improve their function and treatment. Objectives: This study aimed to investigate factors related to the QoL of BC patients in Khuzestan province of Iran. Methods: This descriptive-analytical cross-sectional study was conducted on 180 BC patients in Khuzestan province, Iran. The health-related QoL of patients was measured using the EORTC-QLQ-C30 and EORTC QLQ-BR23 questionnaires. In order to analyze the data and identify relevant factors in health-related quality of life (HRQOL) in BC patients, descriptive statistics and multiple linear regression were performed in SPSS version 22. The statistical significance level was 0.05. Results: The mean QoL score in the patients was 59.58 ± 20.55. Among functional dimensions, the social dimension (80.74 ± 25.85) had the highest score, and sexual pleasure (10.27 ± 20.42) had the lowest score. In the dimension of symptoms, financial difficulties (60.37 ± 31.34) and diarrhea (6.23 ± 16.28) obtained the highest and lowest scores, respectively. There was a significant difference in the mean QoL score regarding different categories of education level (P = 0.01), residence (P = 0.02), supplemental insurance (P = 0.02), employment status (P = 0.02), and duration of illness (P = 0.02). Conclusions: The results of this study can provide many implications for the clinical outcomes and HRQOL of women with BC. Healthcare systems are advised to implement appropriate interventions and healthcare services to optimize QoL-related factors and boost the HRQOL of these patients.
Comparison of the Three Methods of Syntocinon, Misoprostol, Transcervical Catheter Plus Syntocinon in Labor Induction
Authors: Razavi Maryam , Farzaneh Farahnaz
Published: December 2024

: In this interventional study, 120 primigravid women with low bishop scores who visited the maternity room of Ali ibn Abitaleb Hospital in Zahedan (2014) were selected. Patients were randomly assigned to receive syntocinon, misoprostol, or transcervical catheter plus syntocinon. Variables including success rate and side effects were compared among the groups. The success rates in the syntocinon, syntocinon Group plus the trans-cervical catheter, and misoprostol groups were 72.5%, 77.5%, and 65%, respectively, showing no significant difference between the three groups (P = 0.711). The rates of drug adverse effects in the syncinosin, syncinosin plus trans-cervical catheter, and misoprostol groups were 7.5%,7.5%, and 2.5%, respectively. According to the obtained results, the three methods of syntocinon, misoprostol and transcervical catheter with syntocinon, which are low-risk and effective methods for cervical ripening, could be used to terminate pregnancy in primigravida women with low Bishop score before the initiation of labor induction.
IMPROVING OPERATIONAL PERFORMANCE OF AIR PURIFIERS FOR INTERNAL COMBUSTION ENGINES OF KAMAZ VEHICLES BY APPLYING INNOVATIVE SYNTHETIC MATERIALS
Authors: Merchalov S. , Zatonskiy A. , Snyatkov E. , Pryadkin Vladimir
Published: December 2024

The article presents the assessment and analysis of the influence of air dustiness on the operation of the serial filter element of the air cleaner (CE) of the KAMAZ-740 engine with a serial paper filter element (PFE) 740-1109560-02 type DFV 5801 and made of bulk synthetic materials (BSM): po-rous plastic propylene and fluoroplastic-4. As a result of the experimental studies, it was found that the specific dust capacity of the CE with BSM type DFV 5801 is within 1.5 kg/m2, for BSM made of propylene on natural dust it was 1.7 kg/m2, made of fluoroplastic-4 in a dual version it reaches up to 2.6 kg/m2. Consequently, based on the analysis of the studies, it can be concluded that filter elements made of bulk synthetic materials are superior to paper ones in specific dust capacity. It is pos-sible to carry out maintenance more than once, with virtually no changes in performance indicators and use at high humidity and low temperatures.
The Xx-Xy (Female-Male) Gender Theory Aberrationsâ€™ Study Pondering Situations Brought Tremendous Advancements of Gynecological Concern
Authors:   Biosystem Engineer, chartering new Theme, Food is Medicine., Yadav Ram C.
Published: December 2024

This author had conducted deep case by case well known cases on aberrations of xxâ€”xy female gender theory and produced novel method and actual case study data on developments of human biology revealing facts of gynecological concern. The study enabled, in due course, brought new perfection in the original discovery and brought severalinnovative advancement in human reproduction biology. The study on the pondering situation became highly attractive and novel in terms of data sets, revealing health of parents, both mother as well as fathers and produced results of gynecological curiosity. Seeing the widespread interest and coming of innovative advances the Author took the present study to bring up follow up upcoming of updates on scientific developments for broader disseminations revealing the additional scientific facts of gynecology. The study enabled bringing many scientific facts for backing of prevailing customs and initiatives such as Genetic Sustainable Legacy Conservation Fasting>>Healthy Family New World (GESLICOFAST>>HFNW) to end up misbalances in genders in families and keep ancestral legacy umbrella protections with social family harmony. It also envisioned launching of a new scientific research journal entitled, â€œTowards the Better Worldâ€. These initiatives will bring gender balanced parity and many inherent benefits. The study sets right policy and carves path for accomplishing objectives of Sustainable Development Goal (SDG) of the United Nations.
The Secrets & threats of Height Growth, around Menarche in Girls
Authors:   Family Physician & Public Health Consultant, Bengaluru, Karnataka, India., Kishanrao Suresh
Published: December 2024

Peak height velocity (PHV) in girls and boys is typically seen at age 11.5 years for girls and 13.5 years for boys. It is a well-known fact that the height of an individual is influenced most (60-80%) by genetics and the rest 40-20% by other environmental factors-nutrition, playing games etc. Growth around the first period can be a wild ride filled with surprises among girls. During puberty, girls go through a lot of changes, and one of the most noticeable changes is height growth. Whether they grow tall or stay petite, health and confidence matter the most. After all, life isn’t measured in centimetres but in memories, experiences, and the joy of being unique for each girl! An average Indian girl can expect to grow about 6-8 centimetres (cms) after they start periods, but some might grow less, while some others could grow even more than 8 cms. That’s why our culture says every girl is unique and embracing each girl’s individual journey is most important.

Genetics is a significant player in the height game. If parents are tall, their daughters might shoot up. A balanced diet rich in Proteins, vitamins &minerals do support healthy growth. Physical activity is critical it keeps girls fit and promotes bone health. Growth spurts usually happen in bursts! A girl might grow several centimetres in just a few months & then stop for a while. Some girls notice a sudden stretch right after their first period, while others may hop on the growth train a bit later.

It’s essential to recognize that not growing as much as peers or seeing friends shoot up, affects emotionally, as girls feel about themselves & lead to comparisons & self-doubt and may be a concern for the parents too! Engaging in team sports, art, academics build confidence and show that there's more to personal growth than just inches.
From Yoga to Psychological Balance: Exploring Its Impact on Emotional Regulation
Authors:   School of Business Administration, Tourism College of Zhejiang, China, Hangzhou, 311231, ZHANG Jun , XU Jie , WANG Liang ,   School of Business Administration, Tourism College of Zhejiang, China, Hangzhou, 311231, LU Tiantian ,   School of Travel Services and Management, Tourism College of Zhejiang, China, Hangzhou, 311231, JIN Chuncheng ,   Department of Criminal Justice, Zhejiang Police Vocational Academyï¼ŒChina, Hangzhou, 310018, WANG Yao ,   People's Armed Forces Collegeï¼ŒZhejiang Gongshang Universityï¼ŒChina, Hangzhou, 310018, LUO Xiaoyan ,   College of education, Sehan University, Republic of Korea, Jeollanam-do, 650106
Published: December 2024

In recent years, yoga has been shown to effectively improve mental health, reduce symptoms of anxiety and depression, and enhance mood and quality of life. Regular yoga practice helps increase physical flexibility, strength, and cardiovascular function, promotes mindfulness and regulates breathing, significantly alleviating stress and improving self-awareness, thus fostering overall health. As a holistic health promotion approach, yoga demonstrates broad application prospects and profound social impact, and is gaining increasing popularity worldwide.
Assessing The Role of Spleen in Development of Myeloid Bias Amongst Haematopoietic Stem Cells
Authors:   Clem Jones Centre for Regenerative Medicine, Faculty of Health Sciences & Medicine, Bond University, Gold Coast, QLD, Australia., Short Christie , O’Neill Helen , Tan Jonathan ,   Clem Jones Centre for Regenerative Medicine, Faculty of Health Sciences & Medicine, Bond University, Gold Coast, QLD, Australia.
Published: December 2024

Myeloproliferative disorders are common in aged individuals, and ageing is associated with a skewing of haematopoiesis towards myeloid lineage. The spleen houses a distinct resident population of HSC primed for myelopoiesis which retain this myeloid bias even after migration to bone marrow niches. The importance of spleen in the phenotype of myeloid bias with ageing has therefore been investigated here.

Two animal models were studied using CD150hi expression as an indicator of long term (LT)-HSC with a myeloid-biased phenotype. A steady-state model investigated a role for spleen in the age-related increase in myeloid-biased HSC by comparing splenectomised aged female mice with age-matched normal animals. This study showed no significant reduction in the proportion of CD150hi myeloid-biased LT-HSC in splenectomised aged mice compared with age-matched controls, discounting a role for spleen. The second model tested whether extramedullary haematopoiesis in spleen during pregnancy accelerates the redistribution of HSC and increases the myeloid-bias amongst bone marrow LT-HSC. The model utilised exbreeder mice were tested and shown to contain higher numbers of LT-HSC in bone marrow than did age-matched controls, indicating an important role for pregnancy in myeloid bias. The importance of spleen on myeloid bias detected in exbreeder mice was also tested. Young female mice were splenectomised and then exposed to multiple rounds of pregnancy. However, no significant role for spleen was indicated in myeloid bias. A further study compared the number of migratory CD150hi myeloid biased LT-HSC in bone marrow in young and old mice, and in old mice which had undergone splenectomy. The results showed that old mice had no more CCR2+ LT-HSC than young mice, and no significant difference was detected between old and splenectomised old mice, indicating that spleen was not important in expanding the number of migratory CCR2+ LT-HSC.

This study identifies a subset of quiescent, bone marrow resident primitive LT-HSC which acquire myeloid bias with ageing. These are present in higher number in old mice, and in exbreeder mice which have undergone multiple rounds of pregnancy leading to extramedullary hematopoiesis. Data shown here also indicate that spleen plays no significant role in the maintenance of this subset in bone marrow or in the peripheral migration of these cells.
https://www.azpharmjournal.org/en/jurnal/azerbaycan-florasinin-perspektiv-yabani
Authors:   Head of department Nakhchivan State University, Department of pharmacy and biochemistry, Nakhchivan, Azerbaijan,, S.A. Rahimova , N.K. Abbasov ,   Associate Professor, Nakhchivan State University, Faculty of Natural Science and Agriculture, Department of Biology, S.N Abbasli ,   The teacher, Department of basic medical subjects, Nakhchivan State University, Z.M Seyidzada ,   The teacher, Department of pharmacy and biochemistry
Published: December 2024

Studying the antioxidant activity of various fruit plants is an important issue for researchers and is very important in terms of human health and prevention of many diseases. Antioxidant activity of 2 varieties of Prunus cerasifera species growing in the territory of Nakhchivan AR was studied by the DPPH method. The absorbance values of the fruit samples were measured spectrophotometrically at a wavelength of 517 nm by mixing the sample with radical in a ratio of 1:1. The radical scavenging power of antioxidant substances was calculated by drawing an exponential graph from the obtained values. The antioxidant activity of red cherry plum variety was DPPH SC50 (mg/mL) 1.01 ± 0.038 in the sample weighed 6.70g/20 mL, and 2.83 ± 0.043 in the sample weighed 8.97g/20 mL yellow cherry plum variety. Thus, the antioxidant activity of the yellow cherry variety is higher than that of the red cherry variety.
PROTECTIVE ACTIVITY OF HYBRID DERIVATIVES OF TRITERPENOID COUMA-RINS AGAINST INFLUENZA AND HERPES VIRUSES
Authors:   St. Petersburg State Chemical Pharmaceutical University of the Ministry of Health of Russia, A.Z. Abyshev , E.M. Agaev ,   Azerbaijan State Advanced Training Institute for Doctors, A. Aliyev, R.A. Abyshev ,   St. Petersburg State Chemical Pharmaceutical University of the Ministry of Health of Russia, K.B. Nguyen ,   St. Petersburg State Chemical Pharmaceutical University of the Ministry of Health of Russia, A.A. Shtro ,   Research Institute of Influenza, A.A. Smorodintsev, Ministry of Health of Russia
Published: December 2024

The aim of this study was to evaluate the protective properties of new hybrid deriva-tives of triterpenoid-coumarins using models of lethal influenza pneumonia and herpetic con-junctivitis.
Materials and Methods. Animals. The study used two types of animals: female Balb/c mice (16-18 g) and male guinea pigs (400 g). The study employed the influenza virus strain A/California/07/09 (H1N1)pdm09, adapted to mice, from the collection of the Research Insti-tute of Influenza, A.A. Smorodintsev, Ministry of Health of Russia. Passage history: E4/E3M8E1.
Conclusions. The protective activity of some hybrid derivatives of triterpenoid-coumarin was studied in the model of lethal influenza pneumonia caused by the influenza vi-rus and in the model of herpetic conjunctivitis during therapeutic and preventive use.
It was shown that in the model of lethal influenza pneumonia using high doses of the influen-za virus, the use of all compounds improved the dynamics of animal weight, even if the animal mortality coincided with that of the control group. All the tested compounds, except for AV-49, positively affected the dynamics of death in infected animals. The most active compounds were AV-41, AV-42, and AV-53, with protection indices of 45%, 56%, and 34%, respective-ly.
When studying the activity of compounds AV-41, AV-49, and AV-54 with lower doses of the virus, the protective properties of AV-41 and AV-53 were preserved at levels comparable to the reference drug oseltamivir.
When investigating the protective activity of AV-42 and AV-53 in the model of her-petic conjunctivitis, it was shown that both drugs reduced the severity of disease symptoms (both keratitis and blepharitis), though less effectively than the reference drug acyclovir.
Based on the overall protective activity in both viral models, the group of new hybrid triterpe-noid-coumarin derivatives appears promising for further antiviral research.
SYNTHESIS AND STUDY OF ANTIMICROBIAL PROPERTIES OF SULFUR-CONTAINING AMINOMETHOXY COMPOUNDS
Authors:   MSE AR Institute of Petrochemical Processes, Baku, Azerbaijan, Mammadbayli Eldar H. , Jafarov Isa A. ,   Azerbaijan State Pedagogical University, Baku, Azerbaijan, Iskenderova Kamalya O. ,   Azerbaijan State Pedagogical University, Baku, Azerbaijan, Gahramanova Saliga N. ,   Azerbaijan State Pedagogical University, Baku, Azerbaijan, Abiyev Huseyn A. ,   Azerbaijan Medical University, Department of Biological Chemistry, Baku, Azerbaijan
Published: December 2024

Objective of the study: Synthesis of new sulfur-containing Mannich bases based on 1-octylthiohexan-2-ol, secondary amines (diethylamine, dibutylamine, piperidine, morpholine, hexamethyleneimine) and formaldehyde and study of their antimicrobial properties.
Materials and methods: A three-component Mannich reaction was used to synthesize the target products. Elemental analysis, IR, 1H NMR spectroscopy and mass spectrometry were used to determine the structure of the obtained compounds. The disk diffusion method was used to study the antimicrobial activity of the synthesized Mannich bases.
Results: It was found that the synthesized compounds have high antimicrobial activity against gram-positive and gram-negative bacteria (S. aureus, E. coli, P. aeruginosa, K. pneu-moniae), as well as yeast-like fungi of the genus Candida in comparison with standards (rivanol, furacilin, carbolic acid, chloramine).
Conclusion: Based on the obtained results, the synthesized compounds are proposed for use as antimicrobial drugs.
STUDY OF DRUG RESISTANCE OF MALARIA PLASMODIA
Authors:   Department of Intectious Deseaes, Azerbaijan Medical University, Huseynov E. M.
Published: December 2024

Malaria is the main cause of death in tropical and subtropical countries, killing more than 1 million people worldwide each year. Although there are now effective methods to control malaria, the number of malaria cases is still increasing due to several factors. In this emergency, prompt and effec-tive diagnostic and treatment methods are essential for fighting and controlling malaria.Two groups were used for the purpose of research. The standard treatment was held in the first group (3 days), and the prolonged treatment (5 days) - in the second group. All cases with severe malaria course ended by recovery, while besides chemical therapy 33 (94.3%) patients received intravenous desintoxication therapy. Fever duration at the stationary was 3.80±0.42 days, which was longer than chemical therapy. Subfebrilitet duration was observed up to 4 days at the post-fever period in 3 (8.6%) patients. Most of all, asthenic syndrome was observed on average for 17.20±1.49 days in 30 (85.7%) patients during discharging from stationary. The duration of intoxication, complication development, and asthenic syndrome was a reason for a longer period of hospitalization - 18.30±1.39 days. The main treatment of malaria vivax is still chloroquine, which was received by 98.2% of patients. The extension of the treatment course with chloroquine up to 5 days allowed for avoiding the development of earlier re-lapse in the control group.
Efektivitas Online Shop terhadap Kemudahan Belanja Mahasiswa di Yogyakarta
Authors: Pratama Muhammad Rizqi , Khotimah Intan Nur , Taqya Rona Huriya
Published: December 2024

This study aims to examine the influence of Online Shop Effectiveness and Ease of Online Shopping on the shopping experience of students in Yogyakarta. In an increasingly digital era, students, as a group heavily reliant on technology, are opting for e-commerce platforms to fulfill their shopping needs. This research uses a quantitative approach with a sample of 105 students living in Yogyakarta. Data were collected through questionnaires, which were tested using validity, reliability, normality, and hypothesis testing. The results show a significant influence of Online Shop Effectiveness and Ease of Online Shopping on students' satisfaction and convenience in online shopping, with a significance value of 0.00. These findings indicate that factors such as ease of navigation, fast delivery, and flexible payment methods contribute significantly to a positive shopping experience for students. The implications of this research provide insights for e-commerce platform managers to improve their services to meet the growing demand of the student market. This study also contributes to the development of the Technology Acceptance Model (TAM) theory in the context of e-commerce in Indonesia.
İnsani Yardım Lojistiği; Gazze Örneği
Authors: Köseoğlu Salih
Published: December 2024

İnsanlık tarihinden bu yana doğal ve insan kaynaklı afetler, toplumu ciddi şekilde etkileyerek maddi ve manevi kayıplara yol açmıştır. Küreselleşme ile birlikte bu afetlerin sayısı artmış ve toplumların baş etme kapasitelerini zorlamıştır. Afet sonrası insani yardımlar, temel ihtiyaçların karşılanmasında hayati bir rol oynamaktadır. Doğru zaman, yer, kişi ve yöntemle yapılan yardımlar, insani yardım lojistiğinin temelini oluşturur. Bu kavram, özellikle Gazze gibi ambargo ve çatışma altında olan bölgelerde daha da önem kazanmaktadır.
Gazze Şeridi, 2,3 milyonluk nüfusunun büyük çoğunluğunun yoksulluk sınırının altında yaşadığı, küresel çapta en yoğun nüfuslu bölgelerden biridir. 7 Ekim 2023'te başlayan Filistin-İsrail çatışmaları, bölgedeki insani krizi derinleştirmiştir. Ambargolar nedeniyle temel insani ihtiyaçlar karşılanamamakta ve yardım dağıtımı büyük zorluklarla gerçekleştirilmektedir.
Çalışma, insani yardım lojistiğinin önemini vurgulamakta ve Gazze’deki acil ihtiyaçlara odaklanmaktadır. Yardımların hızlı ve etkili bir şekilde ulaştırılması için çözüm önerileri sunulacak, bölgeye yapılan ulusal ve uluslararası yardımlar incelenecektir. Ayrıca, kısa ve uzun vadede insani yardımların sürdürülebilirliğini sağlamak için gerekli stratejiler tartışılacaktır. Gazze’deki durum, insani yardım lojistiğinin çatışma bölgelerinde karşılaştığı zorlukları somut bir örnekle ele almak açısından kritik bir öneme sahiptir.
Dijital Dönüşümün Türkiye'deki Lojistik Firmalarının Operasyonel Verimliliği Üzerindeki Etkileri
Authors: Aktepe Çağlar
Published: December 2024

Dijital dönüşümün lojistik sektöründe özellikle verimlilik, çeviklik ve rekabetçilik açısından kritik bir güç haline geldiği kabul gören bir görüş olmaktadır. Gelişmiş dijital teknolojilerin entegrasyonu ile lojistik operasyonların yeniden şekillendiği ve hizmet kalitesinin arttığı görülmektedir. Bu dönüşüm yalnızca teknolojik olarak gerçekleşmemekte, aynı zamanda organizasyon kültürlerinde ve iş modellerinde de değişim ve gelişimlere sebep olmaktadır. Ancak her yenilik sürecinde olduğu gibi dijital dönüşüm süreci de beraberinde zorluklarla gelmektedir. Lojistik gibi rekabetin yoğun ve karmaşık olduğu bir sektörde ise bu zorluklar daha belirgin ve aşılması güç olmaktadır. Bu sebeple dijital dönüşümün firmaların operasyonel verimlilikleri üzerindeki etkilerini, dijital dönüşüm sürecinde karşılaşılan zorlukları ve başarı faktörlerini anlamak başarıya giden yolda hayati öneme sahiptir. Bu amaca yönelik olarak lojistik sektöründe faaliyet gösteren 8 işletmenin katılımcıları ile birebir yarı yapılandırılmış görüşmeler gerçekleştirilmiştir. Nitel araştırma tasarımı ile analiz edilen bulgular doğrultusunda, dijital dönüşümün operasyonel verimlilik üzerindeki temel kazanımları süreçlerin hızlanması, hata oranlarında azalma ve maliyet düşüşü olarak ortaya çıkmıştır. Dijital dönüşüm sürecindeki temel zorluklar ise kültürel direnç, teknolojik entegrasyon zorlukları ile bütçe sınırlamaları olarak belirtilmiştir. Firmaların bu zorlukların önüne geçmek için uyguladığı stratejiler ise eğitim programlarının düzenlenmesi, etkin değişim yönetimi ve kademeli dijitalleşme süreci olarak ifade edilmiştir. Çalışma, dijital dönüşüm süreçlerinin lojistik sektöründeki çıktılarını ortaya koyması bakımından önem arz etmektedir. Elde edilen bulgular doğrultusunda uygulayıcılara yönelik strateji ve önerilere çalışma sonucunda yer verilmiştir.
Local Wisdom Integration Training in PAIKEM Learning at MTs Salafiyah Syafi'iyah Mojokerto
Authors: Mochammad Yasir  , Try Hartiningsih  , Wiwin Puspita Hadi  , Mochammad Ahied
Published: December 2024

One form of student-centered learning is by integrating local wisdom into PAIKEM learning. Integrating local wisdom into PAIKEM learning is something new at MTs Salafiyah Syafi'iyah Mojokerto because teachers still rarely use local wisdom as a context and content of learning and its use in PAIKEM so that there needs to be community service in the form of training on integrating local wisdom into PAIKEM learning at MTs Salafiyah Syafi'iyah Mojokerto. The purpose of this activity is to train the skills of MTs Salafiyah Syafi'iyah Mojokerto educators in developing PAIKEM learning based on local wisdom to improve the quality of learning. The methods in this activity include (a) expository; (b) question and answer; (c) discussion; (d) demonstration; (e) FGD. The results of this community service activity are that there is an increase in the skills of MTs Salafiyah Syafi'iyah Mojokerto educators in developing PAIKEM learning based on local wisdom in the high category of 23 people and low category of 2 people. The results of these activities can be concluded that the training activities for integrating local wisdom into PAIKEM learning at MTs Salafiyah Syafi'iyah Mojokerto can improve the skills of educators in developing PAIKEM learning based on local wisdom to improve the quality of learning.
Socialization of Aisyiyah Women's Participation
Authors: Adawiyah Sa'diyah El , Endang Sulastri
Published: December 2024

Political participation is the activity of a person or a group of people to actively participate in political life by electing state leaders directly or indirectly, in influencing government policies. Community service activities carried out by the Jakarta PWA Law and Human Rights Council in the Socialization Activity to Increase Women's Participation in the 2024 Jakarta Regional Elections with the following objectives: Increasing the understanding and knowledge of 'Aisyiyah women in political participation in the 2024 regional elections, especially their rights and votes. The activity is in the form of socialization of women's participation in the 2024 regional elections. The participants who attended were representatives of the DKI Jakarta PWA Assembly and institutions, members of the DKI Jakarta PWA Law and Human Rights Assembly, PDA throughout DKI Jakarta, the chairman of the regional leadership of NA, IPM, IMM and IGASI and IGABA, which in total met 150 participants. The results of this community service activity have added new and refreshing insights for 'Aisyiyah women. Increasing knowledge and changing attitudes about the regional elections and the role of 'Aisyiyah women in making them aware of the role of women in fighting for better women's rights through general elections by electing candidates for governor and deputy governor who understand women's rights
Financial Digitalization for SMEs through the SIAPIK Application
Authors: Fisla Wirda  , H Herizon  , Y Yulherniwati
Published: December 2024

Good financial reporting is needed so that financial reports are available accurately and on time. Azizah's crackers business is an SME located in Batu Gadang Village, Lubuk Kilangan District, Padang City  West Sumatra Province. One of the problems in this business is that financial recording is still done manually, so it requires a long process and a high error rate and it is difficult to know the cash flow position quickly and accurately. Making good financial reports requires time as well as knowledge and expertise in the field of accounting, but not all business people have good knowledge and skills in this field. For this reason, an application is needed that helps create financial reports. In this community service activity, the SIAPIK Application (Financial Information Reporting Application System) because this application is issued by Bank Indonesia which has the standards of the Indonesian Accounting Association, is free, and can be used for all types of businesses including manufacturing. Method of implementing activities: planning and preparation through surveys or initial interviews with cracker Uzziah leaders to understand needs and problems, Implementation by providing training and assistance in using SIAPIK, Evaluation is carried out by assessing participants abilities in running the SIAPIK application, Monitoring and follow-up assistance by scheduling periodic visits, Reporting by making activity reports. Azizah's crackers employees participated in the training well and smoothly, the SIAPIK application has been installed on their smartphones, and employees can input data, make transactions, and issue business financial reports
Optimizing Pregnancy Outcomes: The Importance of Pre-Marital and Preconception Care
Authors: Mulyaningsih Erika Agung , Novi Anggraeni  , Amirul Amalia
Published: December 2024

Premarital and preconception care are essential components in improving maternal and newborn health outcomes. This community service aims to evaluate the importance of premarital and preconception counseling, with a focus on its role in reducing the risks associated with unplanned pregnancy, complications during pregnancy, and adverse neonatal outcomes. Although the benefits of premarital and preconception care are clear, access and awareness are still limited in Indonesia, especially among couples planning to marry. This community service was carried out through a national webinar attended by midwifery students, midwives and midwifery/health lecturers. The number of participants was 815 people. Based on the questionnaire that we gave to the midwives, only a few received preconception visits even though the implementation of premarital and preconception care can significantly improve reproductive health outcomes, reduce maternal and infant mortality, and help prospective couples plan a healthy pregnancy. The results of this activity identified barriers to accessing these services, including lack of awareness and education. The hope from this activity is that midwives can expand health education programs aimed at increasing community awareness of the benefits of premarital and preconception care in creating healthier family planning outcomes
Influence of Profit Management, Transfer Pricing, and Capital Intensity on Tax Avoidance with Company Size as A Moderation Variable
Authors: Fitriani Riri , Taqi Muhamad
Published: December 2024

This research aims to determine the effect of earnings management, transfer pricing, and capital intensity on tax avoidance with company size as a moderating variable. The research objects used in this research are manufacturing companies listed on the Indonesia Stock Exchange (BEI) in 2018-2023. This research is a type of quantitative research with multiple linear regression models and Moderated Regression Analysis (MRA). In selecting samples that met the criteria, 30 companies were obtained. This research uses secondary data based on manufacturing company financial reports obtained from the Indonesia Stock Exchange website and related company websites. Data processing was carried out using the SPSS 25 application program. Partial research results showed that earnings management had an effect on tax avoidance, transfer pricing had an effect on tax avoidance, capital intensity had no effect on tax avoidance while moderated regression analysis (MRA) testing showed that company size moderated the effect of earnings management on tax avoidance, company size cannot moderate the effect of transfer pricing on tax avoidance, and company size cannot moderate the effect of capital intensity on tax avoidance.
МЕТОДИЧЕСКИЕ АСПЕКТЫ ФОРМИРОВАНИЯ И РАЗВИТИЯ КОММУНИКАТИВНЫХ КОМПЕТЕНЦИЙ УЧАЩИХСЯ 5-9-х КЛАССОВ
Authors: Давлеткулова Г.Ш. , Тагирова С.А.
Published: December 2024

В данной статье описываются интонационные умения и навыки, которыми должны владеть учащиеся 5-9 классов общеобразовательных организаций, ход экспериментальных исследований, итоги констатирующего и опытного экспериментов, приводятся примерные упражнения и задания для совершенствования интонационных умений и навыков учащихся.
Методы формирования компьютерных неологизмов
Authors: Аубакирова Б.К. , Абильмажинова Б. Ж.
Published: December 2024

В статье рассмотрена закономерность естественного происхождения новых слов в области языка, которые постоянно появляются и постепенно выходят из процесса последующего употребления. В связи с указанными изменениями возникает актуальность процесса определения номинативного наименования возникающих новых понятий. В результате развития информационных технологий возникли новые формы коммуникативной деятельности. Известно, что резкое возникновение проблем создания нового слова по причине происходящих в результате изменений коммуникативной деятельности процессов является естественным процессом. Динамично развивающаяся социальная среда, постоянные изменения и инновации в научно-техническом направлении оказывают мощное влияние на языковую сферу. В связи с этим словарный состав языка постоянно интенсивно пополняется новыми элементами. В рамках нашей небольшой исследовательской работы было рассмотрено, как явление гибкой части общей лексики в направлении языковой сферы, склонной к процессу изменения. Рассмотрены влияние различных факторов, развивающихся в обществе, специфические особенности использования нелогизмов, активно применяемых и в области информационных технологий, направления создания и использования компьютерных языковых единиц. Это связано с тем, что в настоящее время каждый язык постоянно пополняется новыми лексическими единицами благодаря средствам массовой информации. Закономерность возникновения и формирования нового понятия в языке рассматривалась с точки зрения функционального аспекта языка в современном обществе. Здесь предусматривалось раскрытие приоритетных направлений выявления неологизма, входящих в главную проблему - появление новых слов, способы распознавания их значений, определение их функциональной функции. В соответствии с прагматической потребностью общества были дифференцированы на основе анализа факторов, повлиявших на их появление, способов употребления новых слов, изучения моделей построения. Рассмотрен языковой характер общения, осуществляемого через Компьютер. Своеобразные мотивы англицизмов, адаптированные и официально вошедшие в словарный запас, получили теоретический обзор и научные определения трудов отечественных и зарубежных ученых.
ҚАЗІРГІ ЖАСӨСПІРІМДЕР АРАСЫНДА СПОРТТЫ ДАМЫТУ
Authors: Оразбаева К.О. , Жансерик З.
Published: December 2024

Мақалада келтірілген материалдар қазіргі жасөспірімдердің физикалық және психофизиологиялық денсаулығын спорт арқылы нығайту және салауатты өмір салтын қалыптастыру мақсатында теориялық тұрғыдан қарастырылған. Сонымен қатар ғалымдардың еңбектеріне шолу жасай отырып, қоғам ортасында жасөспірімдердің жетістікке жету жолдарының көптеген мүмкіндіктері бар екендігі айтылған. Жасөспірімдер арасында спортта жетістікке жету үшін психологиялық-педагогикалық жағдай жасау, яғни олардың жағдайларын анықтауға мүмкіндік береді. Демек, озық дәстүрлерін қалпына келтіру жасөспірімдер арасында спортты дамытудың жаңа тиімді тетіктерін іздестіру, әртүрлі ортада жасөспірімдерді дене шынықтыру және сауықтыру іс-шараларына тарту маңызды міндеттер болып отыр. Спорттың жасөспірімдердің тұлғалық және кәсіби өсуіне ықпалы зор, сондықтан да спортқа мемлекет тарапынан барлық деңгейде қолдау көрсетіледі. Осыған байланысты жасөспірімдер арасында спортты дамыту қажеттілігін қарастырудың маңыздылығы арта түседі.