bluuebunny/crossref_metadata_2025 huggingface dataset:
Pediatric Echinococcosis of the Liver in Austria: Clinical and Therapeutical Considerations
Authors: Hager Josef , Sergi Consolato M.
Published: April 2023

Echinococcosis is considered a neglected disease in most European countries. However, migratory flows of populations, long-term stays in endemic areas, uninterrupted tourism (travel to Echinococcus-endemic countries), traveling dogs and dog translocations from endemic areas, and inappropriate hygiene practices are potential factors that alarm public health officials. Identifying a cyst-like mass in the liver or lung of an individual with a travel history of likely exposure to sheepdogs in an area where the parasite Echinococcus (E.) granulosus (sive cysticus) is endemic advocates for a prompt preliminary diagnosis of cystic echinococcosis (CE), no matter the age of the affected individuals. Routine imaging techniques, including ultrasonography, computed tomography (CT) scans, and magnetic resonance imaging (MRI) scans, are used to detect cysts. After a cyst has been discovered, serologic investigations are used to confirm the diagnosis. Typically, alveolar echinococcosis (AE) is found in older individuals. Yet young people are also affected because frequent oral exploration of the environment is a regular behavior for infants and toddlers. In this review, therapeutic considerations for pediatric echinococcosis—drug-based benzimidazole therapy; AE: atypical liver resection, the resection of individual or multiple segments, a right or left hemi-hepatectomy, or an extended hemi-hepatectomy; CE: PAIR-technique, cyst excision, liver segment(s) resection (laparoscopically or conventionally)—are revised following experience in one of the most affected regions of Europe. In addition, we performed a systematic review using three databases (i.e., PubMed, EMBASE, and Scopus) to evaluate the quality of evidence in published studies on pediatric echinococcosis.
A Modified Shielding and Rapid Transition DDES Model for Separated Flows
Authors: Lei Da , Yang Hui , Zheng Yun , Gao Qingzhe , Jin Xiubo
Published: April 2023

In this paper, the major problems associated with detached eddy simulation (DES) (namely, modeled stress depletion (MSD) and slowing of the RANS to LES transition (RLT)) are discussed and reviewed, and relevant improvements are developed. A modified version for the delayed DES (DDES) method with adaptive modified adequate shielding and rapid transition is proposed; this is called MSRT DDES. The modified shielding strategy can be adjusted adaptively according to the local flow conditions: keeping the RANS behavior in the whole boundary layer when there is no resolved turbulence, and weakening the shielding function when resolved turbulence exists in the mainstream over the boundary layer. This strategy can significantly ameliorate the MSD in the RANS boundary layer, regardless of the mesh refinement, and avoid excessive shielding in the fully developed resolved turbulence that may otherwise delay the development of the separated and reattached flow. Three cases are designed to test the modified DDES, namely, complete shielding in the RANS zone of a boundary layer (the zero-pressure gradient turbulent boundary layer with the refined mesh), modified adaptive improved shielding with a rapid transition (the flow over a hump), and the overall performance in a complex 3D separation (the corner separation in a compressor cascade). The results show that the modified shielding function is more physical than earlier proposals compared to shielding functions, and according to detailed comparisons of the wall skin friction coefficients, velocity profiles, total pressure-loss coefficients, entropy production analyses, and so on, the MSD and RLT problems are moderately alleviated by the MSRT DDES.
Dimensionless Groups by Entropic Similarity: I — Diffusion, Chemical Reaction and Dispersion Processes
Authors: Niven Robert K.
Published: April 2023

Since the time of Buckingham in 1914, dimensional analysis and similarity arguments based on dimensionless groups have served as powerful tools for the analysis of systems in all branches of science and engineering. Dimensionless groups are generally classified into those arising from geometric similarity, based on ratios of length scales; kinematic similarity, based on ratios of velocities or accelerations; and dynamic similarity, based on ratios of forces. We propose an additional category of dimensionless groups based on entropic similarity, defined by ratios of (i) entropy production terms; (ii) entropy flow rates or fluxes; or (iii) information flow rates or fluxes. Since all processes involving work against friction, dissipation, diffusion, dispersion, mixing, separation, chemical reaction, gain of information or other irreversible changes are driven by (or must overcome) the second law of thermodynamics, it is appropriate to analyze them directly in terms of competing entropy-producing and transporting phenomena and the dominant entropic regime, rather than indirectly in terms of forces. In this study, entropic groups are derived for a wide variety of diffusion, chemical reaction and dispersion processes relevant to fluid mechanics, chemical engineering and environmental engineering. It is shown that many dimensionless groups traditionally derived by kinematic or dynamic similarity (including the Reynolds number) can also be recovered by entropic similarity—with a different entropic interpretation—while many new dimensionless groups can also be identified. The analyses significantly expand the scope of dimensional analysis and similarity arguments for the resolution of new and existing problems in science and engineering.
Interdisciplinarity in Physical Education: Effect on Students’ Situational Interest
Authors: Tonnetti Benoit , Lentillon-Kaestner Vanessa
Published: April 2023

The purpose of this paper is to estimate the effect of interdisciplinary teaching in physical education (PE) on the interest of upper secondary students by considering the extent to which different disciplines are integrated. Three interdisciplinary projects are studied and compared to their discipline-based counterparts. Depending on the extent to which the disciplines are integrated, some sequences are considered interdisciplinary (project 1), while others are considered multidisciplinary (projects 2 and 3). The experimental design includes a total of 90 students and six teachers. Student interest is measured using a situational interest (SI) scale and an individual interest (II) scale. Paired t-tests show significant differences for Maintained-SI Feelings in PE (p = 0.008) in favor of the interdisciplinary sequence for project 1 (PE and art), as well as for Maintained-SI Feelings (p = 0.004) and Maintained-SI Value (p = 0.002) in art (project 1). However, when integration is limited (projects 2 and 3), higher Maintained-SI Feelings (p < 0.001) are measured in the disciplinary sequence during the PE lessons. These results show that interdisciplinary sequences have positive effects on students’ interest when the disciplines are sufficiently integrated, indicating that training must be initially developed and maintained accordingly.
Optimizing Large-Scale PV Systems with Machine Learning: A Neuro-Fuzzy MPPT Control for PSCs with Uncertainties
Authors: Asif  , Ahmad Waleed , Qureshi Muhammad Bilal , Khan Muhammad Mohsin , Fayyaz Muhammad A. B. , Nawaz Raheel
Published: April 2023

The article proposes a new approach to maximum power point tracking (MPPT) for photovoltaic (PV) systems operating under partial shading conditions (PSCs) that improves upon the limitations of traditional methods in identifying the global maximum power (GMP), resulting in reduced system efficiency. The proposed approach uses a two-stage MPPT method that employs machine learning (ML) and terminal sliding mode control (TSMC). In the first stage, a neuro fuzzy network (NFN) is used to improve the accuracy of the reference voltage generation for MPPT, while in the second stage, a TSMC is used to track the MPP voltage using a non-inverting DC—DC buck-boost converter. The proposed method has been validated through numerical simulations and experiments, demonstrating significant enhancements in MPPT performance even under challenging scenarios. A comprehensive comparison study was conducted with two traditional MPPT algorithms, PID and P&O, which demonstrated the superiority of the proposed method in generating higher power and less control time. The proposed method generates the least power loss in both steady and dynamic states and exhibits an 8.2% higher average power and 60% less control time compared to traditional methods, indicating its superior performance. The proposed method was also found to perform well under real-world conditions and load variations, resulting in 56.1% less variability and only 2–3 W standard deviation at the GMPP.
Research on Detection and Recognition Technology of a Visible and Infrared Dim and Small Target Based on Deep Learning
Authors: Dong Yuxing , Li Yan , Li Zhen
Published: April 2023

With the increasing trend towards informatization and intelligence in modern warfare, high-intensity and continuous reconnaissance activities are becoming increasingly common in battlefield environments via airborne, vehicle, UAV, satellite and other platforms. Visible and infrared images are preferred due to their high resolution, strong contrast, rich texture details and color features, and strong information expression ability. However, the quality of imaging is easily affected by environmental factors, making it crucial to quickly and accurately filter useful information from massive image data. To this end, super-resolution image preprocessing can improve the detection performance of UAV, and reduce false detection and missed detection of targets. Additionally, super-resolution reconstruction results in high-quality images that can be used to expand UAV datasets and enhance the UAV characteristics, thereby enabling the enhancement of small targets. In response to the challenge of “low-slow small” UAV targets at long distances, we propose a multi-scale fusion super-resolution reconstruction (MFSRCNN) algorithm based on the fast super-resolution reconstruction (FSRCNN) algorithm and multi-scale fusion. Our experiments confirm the feasibility of the algorithm in reconstructing detailed information of the UAV target. On average, the MFSRCNN reconstruction time is 0.028 s, with the average confidence before and after reconstruction being 80.73% and 86.59%, respectively, resulting in an average increase of 6.72%.
Techno-Economic Evaluation of Hydrogen-Based Cooking Solutions in Remote African Communities—The Case of Kenya
Authors: Schöne Nikolas , Dumitrescu Raluca , Heinz Boris
Published: April 2023

Hydrogen has recently been proposed as a versatile energy carrier to contribute to archiving universal access to clean cooking. In hard-to-reach rural settings, decentralized produced hydrogen may be utilized (i) as a clean fuel via direct combustion in pure gaseous form or blended with Liquid Petroleum Gas (LPG), or (ii) via power-to-hydrogen-to-power (P2H2P) to serve electric cooking (e-cooking) appliances. Here, we present the first techno-economic evaluation of hydrogen-based cooking solutions. We apply mathematical optimization via energy system modeling to assess the minimal cost configuration of each respective energy system on technical and economic measures under present and future parameters. We further compare the potential costs of cooking for the end user with the costs of cooking with traditional fuels. Today, P2H2P-based e-cooking and production of hydrogen for utilization via combustion integrated into the electricity supply system have almost equal energy system costs to simultaneously satisfy the cooking and electricity needs of the isolated rural Kenyan village studied. P2H2P-based e-cooking might become advantageous in the near future when improving the energy efficiency of e-cooking appliances. The economic efficiency of producing hydrogen for utilization by end users via combustion benefits from integrating the water electrolysis into the electricity supply system. More efficient and cheaper hydrogen technologies expected by 2050 may improve the economic performance of integrated hydrogen production and utilization via combustion to be competitive with P2H2P-based e-cooking. The monthly costs of cooking per household may be lower than the traditional use of firewood and charcoal even today when applying the current life-line tariff for the electricity consumed or utilizing hydrogen via combustion. Driven by likely future technological improvements and the expected increase in traditional and fossil fuel prices, any hydrogen-based cooking pathway may be cheaper for end users than using charcoal and firewood by 2030, and LPG by 2040. The results suggest that providing clean cooking in rural villages could economically and environmentally benefit from utilizing hydrogen. However, facing the complexity of clean cooking projects, we emphasize the importance of embedding the results of our techno-economic analysis in holistic energy delivery models. We propose useful starting points for future aspects to be investigated in the discussion section, including business and financing models.
Multi-Microgrid Collaborative Optimization Scheduling Using an Improved Multi-Agent Soft Actor-Critic Algorithm
Authors: Gao Jiankai , Li Yang , Wang Bin , Wu Haibo
Published: April 2023

The implementation of a multi-microgrid (MMG) system with multiple renewable energy sources enables the facilitation of electricity trading. To tackle the energy management problem of an MMG system, which consists of multiple renewable energy microgrids belonging to different operating entities, this paper proposes an MMG collaborative optimization scheduling model based on a multi-agent centralized training distributed execution framework. To enhance the generalization ability of dealing with various uncertainties, we also propose an improved multi-agent soft actor-critic (MASAC) algorithm, which facilitates energy transactions between multi-agents in MMG, and employs automated machine learning (AutoML) to optimize the MASAC hyperparameters to further improve the generalization of deep reinforcement learning (DRL). The test results demonstrate that the proposed method successfully achieves power complementarity between different entities and reduces the MMG system’s operating cost. Additionally, the proposal significantly outperforms other state-of-the-art reinforcement learning algorithms with better economy and higher calculation efficiency.
Novel Planning Methodology for Spatially Optimized RES Development Which Minimizes Flexibility Requirements for Their Integration into the Power System
Authors: Škrbić Bojana , Đurišić Željko
Published: April 2023

An optimization model which determines optimal spatial allocation of wind (WPPs) and PV power plants (PVPPs) for an energy independent power system is developed in this paper. Complementarity of the natural generation profiles of WPPs and PVPPs, as well as differences between generation profiles of WPPs and PVPPs located in different regions, gives us opportunity to optimize the generation capacity structure and spatial allocation of renewable energy sources (RES) in order to satisfy the energy needs while alleviating the total flexibility requirements in the power system. The optimization model is based on least squared error minimization under constraints where the error represents the difference between total wind and solar generation and the referent consumption profile. This model leverages between total energy and total power requirements that flexibility resources in the considered power system need to provide in the sense that the total balancing energy minimization implicitly bounds the power imbalances over the considered time period. Bounding the power imbalances is important for minimizing investment costs for additional flexibility resources. The optimization constraints bound the installed power plant capacity in each region according to the estimated technically available area and force the total energy production to equal the targeted energy needs. The proposed methodology is demonstrated through the example of long-term RES planning development for complete decarbonization of electric energy generation in Serbia. These results could be used as a foundation for the development of the national energy strategy by serving as a guidance for defining capacity targets for regional capacity auctions in order to direct the investments in wind and solar power plants and achieve transition to dominantly renewable electricity production.
A Review on Power Electronic Converters for Modular BMS with Active Balancing
Authors: Miranda João P. D. , Barros Luis A. M. , Pinto José Gabriel
Published: April 2023

Electric vehicles (EVs) are becoming increasingly popular due to their low emissions, energy efficiency, and reduced reliance on fossil fuels. One of the most critical components in an EV is the energy storage and management system, which requires compactness, lightweight, high efficiency, and superior build quality. Active cell equalization circuits such as those used in battery management systems (BMS) have been developed to balance the voltage and state of charge (SoC) of individual cells, ensuring the safety and reliability of the energy storage system. The use of these types of equalization circuits offers several benefits including improved battery performance, extended battery life, and enhanced safety, which are essential for the successful adoption of EVs. This paper provides a comprehensive overview of the research works related to active cell equalization circuits. This review highlights the important aspects, advantages and disadvantages, and specifications.
Examining the Effects of Environmental Knowledge and Health Insurance Coverage on Health Status
Authors: Liu Yong , Ruiz-Menjivar Jorge , Lepheana Mosili , Carr Brent R.
Published: April 2023

Rural women in developing nations are especially vulnerable to higher health risks due to environmental pollution exposure and are more likely to experience poorer health outcomes. Using data from the 2013 China General Social Survey CGSS2013, this study empirically examined the relationship among environmental knowledge (EK), pollution, health investment (i.e., holding and purchasing a public health insurance policy, engaging in frequent physical activity, and acquiring commercial insurance), and health status. The sample was composed of 1930 women residing in rural regions in China. Three main research questions are investigated: whether environmental knowledge affects health investment and health status, whether health investments impact health status, and whether the relationship between environmental knowledge and health status is mediated by health investment. Our results showed that the level of EK for women in rural China significantly impacted their self-reported physical and mental health. To account for potential endogeneity due to mutual causality, this study employed television usage and network usage as two instrumental variables (IVs) of EK and used an IV-probit method. Additionally, we estimated a model that replaced health status with the variable Body Mass Index (BMI) to assess the reliability and robustness of our results. The results were consistent, providing evidence of robustness. Additionally, we examined the relationship between health investment (holding and purchasing a public health insurance policy, engaging in frequent physical activity, and acquiring commercial insurance) and health status. Our results indicated that the level of EK had no significant impact on participating in the new rural cooperative medical system. However, the preference for purchasing commercial insurance was positively impacted by EK, though it did not directly affect health status. Conversely, an increase in EK and pollution was associated with a greater likelihood of engaging in physical exercise, which, in turn, improved overall mental health.
Modeling-Based Risks Assessment and Management of Climate Change in South Korean Forests
Authors: Hong Mina , Song Cholho , Kim Moonil , Kim Jiwon , Roh Minwoo , Ko Youngjin , Cho Kijong , Son Yowhan , Jeon Seongwoo , Kraxner Florian , Lee Woo-Kyun
Published: April 2023

The IPCC emphasizes the role of forests in the sequestration of greenhouse gases, a significant cause of climate change. Accordingly, it shows the importance of predicting changes in forests due to climate change, evaluating them to reduce vulnerability under adaptive capacity, and finding ways to find climate resilient development pathways. In this study, the KO-G-Dynamic model, a Korean growth model, was linked with the frameworks of AR5 and 6 to assess risk dynamics in the forest growth sector. At this time, the sensitivity is a variability due to the reduction in forest growth, the exposure is the forest as an object, the hazard is climate change, the adaptive capacity is forest management, and the vulnerability is a mechanism that sensitivity could not be adjusted according to adaptive capacity. The risk was assessed by ranking overall risks derived from the process of vulnerability generated by the interaction of the above factors. As a result, the current forests in Korea are age class imbalanced, and the effects of distribution are centered on fast-growing tree species. If climate change and overprotection continue, the vulnerable area expands as sensitivity increases, since the total growth reduces due to increasing over-matured forests. From the regional-based analysis, Gangwon-do and Gyeongsangnam-do mostly consist of the higher V age class, the ratio of ‘very high’ risk grade was high and the area of ‘high’ risk grade changed rapidly. However, after applying forest management scenarios of adaptive capacity such as harvesting, reforestation, and thinning based on Republic of Korea’s forest management policy, the ratio of ‘Low’ risk grades increased according to the reduction of vulnerability areas. Therefore, forest management can act as an important factor to reduce the risk of forest growth in response to climate change.
Gastric Syphilis Presenting as a Nodal Inflammatory Pseudotumor Mimicking a Neoplasm: Don’t Forget the Treponema! Case Report and Scoping Review of the Literature of the Last 65 Years
Authors: Sinagra Emanuele , Macaione Ina , Stella Mario , Shahini Endrit , Maida Marcello , Pompei Giancarlo , Rossi Francesca , Conoscenti Giuseppe , Alloro Rita , Di Ganci Simona , Ricotta Calogero , Testai Sergio , Marasà Marta , Scarpulla Giuseppe , Rizzo Aroldo Gabriele , Raimondo Dario
Published: April 2023

Despite the fact that gastric syphilis is considered rare, it is reported as a type of organic involvement that is present in a large proportion of secondary syphilis cases, even though gastritis presenting with symptoms is extremely rare. Clinical, radiological, and endoscopic findings are non-specific and frequently mimic the symptoms of gastric adenocarcinoma or lymphoma, making diagnosis difficult. Immunostaining is required for this diagnosis. We would like to emphasize the importance of being suspicious of GS when a gastric mass exhibits the histologic features of an inflammatory pseudotumor (IPT), as previously reported for nodal IPT caused by luetic infection. We described a 56-year-old man who presented to the oncology department with a 3-month history of anorexia, epigastric pain, nausea, vomiting, and weight loss, as well as an initial radiological and endoscopic suspicion of gastric adenocarcinoma, in which immune staining allowed us to diagnose GS. In addition, we conducted an updated scoping review of the scientific literature to show the clinical, laboratory, and therapeutic findings in GS patients over the last 65 years.
An MPS-Based 50plex Microhaplotype Assay for Forensic DNA Analysis
Authors: Zhang Ranran , Xue Jiaming , Tan Mengyu , Chen Dezhi , Xiao Yuanyuan , Liu Guihong , Zheng Yazi , Wu Qiushuo , Liao Miao , Lv Meili , Qu Shengqiu , Liang Weibo
Published: April 2023

Microhaplotypes (MHs) are widely accepted as powerful markers in forensic studies. They have the advantage of both short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs), with no stutter and amplification bias, short fragments and amplicons, low mutation and recombination rates, and high polymorphisms. In this study, we constructed a panel of 50 MHs that are distributed on 21 chromosomes and analyzed them using the Multiseq multiple polymerase chain reaction (multi-PCR) targeted capture sequencing protocol based on the massively parallel sequencing (MPS) platform. The sizes of markers and amplicons ranged between 11–81 bp and 123–198 bp, respectively. The sensitivity was 0.25 ng, and the calling results were consistent with Sanger sequencing and the Integrative Genomics Viewer (IGV). It showed measurable polymorphism among sequenced 137 Southwest Chinese Han individuals. No significant deviations in the Hardy–Weinberg equilibrium (HWE) and linkage disequilibrium (LD) were found at all MHs after Bonferroni correction. Furthermore, the specificity was 1:40 for simulated two-person mixtures, and the detection rates of highly degraded single samples and mixtures were 100% and 93–100%, respectively. Moreover, animal DNA testing was incomplete and low depth. Overall, our MPS-based 50-plex MH panel is a powerful forensic tool that provides a strong supplement and enhancement for some existing panels.
Investigation of NLR Genes Reveals Divergent Evolution on NLRome in Diploid and Polyploid Species in Genus Trifolium
Authors: Areej Amna , Nawaz Hummera , Aslam Iqra , Danial Muhammad , Qayyum Zohaib , Rasool Usama Akhtar , Asif Jehanzaib , Khalid Afia , Serfraz Saad , Saleem Fozia , Mubin Muhammad , Shoaib Muhammad , Shahnawaz-ul-Rehman Muhammad , Nahid Nazia , Alkahtani Saad
Published: April 2023

Crop wild relatives contain a greater variety of phenotypic and genotypic diversity compared to their domesticated counterparts. Trifolium crop species have limited genetic diversity to cope with biotic and abiotic stresses due to artificial selection for consumer preferences. Here, we investigated the distribution and evolution of nucleotide-binding site leucine-rich repeat receptor (NLR) genes in the genus of Trifolium with the objective to identify reference NLR genes. We identified 412, 350, 306, 389 and 241 NLR genes were identified from Trifolium. subterraneum, T. pratense, T. occidentale, subgenome-A of T. repens and subgenome-B of T. repens, respectively. Phylogenetic and clustering analysis reveals seven sub-groups in genus Trifolium. Specific subgroups such as G4-CNL, CCG10-CNL and TIR-CNL show distinct duplication patterns in specific species, which suggests subgroup duplications that are the hallmarks of their divergent evolution. Furthermore, our results strongly suggest the overall expansion of NLR repertoire in T. subterraneum is due to gene duplication events and birth of gene families after speciation. Moreover, the NLRome of the allopolyploid species T. repens has evolved asymmetrically, with the subgenome -A showing expansion, while the subgenome-B underwent contraction. These findings provide crucial background data for comprehending NLR evolution in the Fabaceae family and offer a more comprehensive analysis of NLR genes as disease resistance genes.
Genome-Wide Identification and Expression Analysis of the SHI-Related Sequence Family in Cassava
Authors: Huang Huling , Song Jiming , Feng Yating , Zheng Linling , Chen Yinhua , Luo Kai
Published: April 2023

The SHORT INTERNODES (SHI)-related sequences (SRS) are plant-specific transcription factors that have been quantitatively characterized during plant growth, regeneration, and stress responses. However, the genome-wide discovery of SRS family genes and their involvement in abiotic stress-related activities in cassava have not been documented. A genome-wide search strategy was used to identify eight family members of the SRS gene family in cassava (Manihot esculenta Crantz). Based on their evolutionary linkages, all MeSRS genes featured homologous RING-like zinc finger and IXGH domains. Genetic architecture and conserved motif analysis validated the categorization of MeSRS genes into four groups. Eight pairs of segmental duplications were detected, resulting in an increase in the number of MeSRS genes. Orthologous studies of SRS genes among cassava and three different plant species (Arabidopsis thaliana, Oryza sativa, and Populus trichocarpa) provided important insights into the probable history of the MeSRS gene family. The functionality of MeSRS genes was elucidated through the prediction of protein–protein interaction networks and cis-acting domains. RNA-seq data demonstrated tissue/organ expression selectivity and preference of the MeSRS genes. Furthermore, qRT-PCR investigation of MeSRS gene expression after exposure to salicylic acid (SA) and methyl jasmonate (MeJA) hormone treatments, as well as salt (NaCl) and osmotic (polyethylene glycol, PEG) stresses, showed their stress-responsive patterns. This genome-wide characterization and identification of the evolutionary relationships and expression profiles of the cassava MeSRS family genes will be helpful for further research into this gene family and its function in stress response. It may also assist future agricultural efforts to increase the stress tolerance of cassava.
Shakespeare and the Book of Henry
Authors: Herman Peter C.
Published: April 2023

In this article, I argue that the four plays of the Henriad (Richard II, 1 and 2 Henry IV, and Henry V), as presented in the 1623 Folio, constitute a unified whole intended for reading. The plays are connected not only by the endings of one play leading directly into the beginning of the next, but they are also unified by thematic and verbal echoes. I will focus first on establishing the connections between the plays, and then on the thematic resonances. I show how the plays are connected by verbal echoes, some thematically relevant, some not. I then show how Shakespeare provides differing accounts of Richard’s fall and invites the reader the compare and contrast them with each other. Finally, I turn to Shakespeare’s treatment of the common soldier, which culminates in the confrontation between the disguised Henry V and Michael Williams, Alexander Court, and John Bates, a scene not present in the quarto version of this play. Although this scene can stand alone, one has to have read the previous chapters of the Henriad to comprehend the full force of Shakespeare’s revision.
Comparison of Acute Arterial Responses Following a Rescue Simulation and Maximal Exercise in Professional Firefighters
Authors: Santos Vanessa , Massuça Luís Miguel , Monteiro Luís , Angarten Vítor , Abel Mark G. , Fernhall Bo , Santa-Clara Helena
Published: April 2023

Cardiovascular events are the leading cause of on-duty deaths among firefighters. Screening firefighters for risk of sudden cardiac event is a critical element of a comprehensive medical program. Although intense physical exertion has been shown to trigger sudden cardiac events in the general population, it is unclear how hemodynamic responses following clinical exercise testing compare to that of performing firefighting tasks in personal protective equipment. Therefore, the purpose of this study was to compare hemodynamic responses following rescue simulation (RS) and maximal exercise in firefighters. This was a cross-over repeated measures study. Thirty-eight professional firefighters (31.8 ± 5.2 yr; VO2peak: 57.9 mL/kg/min) completed a maximal aerobic exercise test (MAET) and an RS. Pulse wave velocity (PWV), pulse pressure (PP), and brachial and central mean arterial pressure (MAP) were measured before and 5 and 15 min post-exercise. The findings indicated that femoral PWV decreased after MAET and RS at both time points (p < 0.005). No significant differences were found in aortic and carotid PWV over time or between conditions (p ≥ 0.05). Significant increases in brachial and central PP and MAP were noted 5 min post-MAET and RS (p = 0.004). In conclusion, the present study demonstrated that peripheral arterial stiffness (AS) decreased in firefighters following both conditions, with no differences in central AS. Our findings provide valuable information on hemodynamic responses similar between RS and MAET, and are important for controlling CVD risk and the AS response.
“Sex Should Not be Part of the Lives of Persons with Disabilities, but They Are Human Beings too”: Perceptions of Healthcare Providers and Factors Affecting Service Delivery in Ghana
Authors: Seidu Abdul-Aziz , Malau-Aduli Bunmi S. , McBain-Rigg Kristin , Malau-Aduli Aduli E. O. , Emeto Theophilus I.
Published: April 2023

Persons with disabilities (PwDs) constitute about 16% of the global population and face many challenges in every society, including access to sexual and reproductive healthcare. The attitudes of healthcare providers (HPs) exert a major influence on PwDs accessing sexual and reproductive healthcare (SRH). A sequential explanatory mixed methods design was used to investigate the attitudes and perceptions of HPs towards PwDs and SRH delivery in Ghana’s Ashanti region. Quantitative data analysis indicated that overall, 82% of HPs had received information on disability-related issues and had relatively positive attitude towards PwDs, which varied across sub-scales of the Attitude Towards Disability score and associated with their sociodemographic characteristics. HPs faced several challenges in SRH services delivery to PwDs, which included a lack of funding and training, and inadequate staff. Inductive thematic analysis of the qualitative data revealed eight overarching themes. The findings revealed that HPs had prejudice about the mental and sexual health abilities of PwDs. Inadequate skill set, inadequate resources, and limited funding were major challenges identified. Nonetheless, compassion and benevolence towards PwDs, improvision, economic and educational support, awareness creation, and referrals were strategies adopted to overcome these challenges. Mandatory training of HPs is recommended to ensure improved SRH service delivery to PwDs. Future research could explore the perceptions and coping strategies of PwDs.
Molecular Tumor Boards: The Next Step towards Precision Therapy in Cancer Care
Authors: Liu Angela , Vicenzi Paige , Sharma Ishna , Orr Kaci , Teller Christa , Koentz Micha , Trinkman Heidi , Vallance Kelly , Ray Anish
Published: April 2023

The application of molecular tumor profiles in clinical decision making remains a challenge. To aid in the interpretation of complex biomarkers, molecular tumor boards (MTBs) have been established worldwide. In the present study, we show that a multidisciplinary approach is essential to the success of MTBs. Our MTB, consisting of pediatric oncologists, pathologists, and pharmacists, evaluated 115 cases diagnosed between March 2016 and September 2021. If targetable mutations were identified, pharmacists aided in the evaluation of treatment options based on drug accessibility. Treatable genetic alterations detected through molecular testing most frequently involved the cell cycle. For 85% of the cases evaluated, our MTB provided treatment recommendations based on the patient’s history and results of molecular tumor testing. Only three patients, however, received MTB-recommended targeted therapy, and only one of these patients demonstrated an improved clinical outcome. For the remaining patients, MTB-recommended treatment often was not administered because molecular tumor profiling was not performed until late in the disease course. For the three patients who did receive MTB-recommended therapy, such treatment was not administered until months after diagnosis due to physician preference. Thus, the education of healthcare providers regarding the benefits of targeted therapy may increase acceptance of these novel agents and subsequently improve patient survival.
Antibacterial Activity of Ginkgo biloba Extracts against Clavibacter michiganensis subsp. michiganensis, Pseudomonas spp., and Xanthomonas vesicatoria
Authors: Sánchez-Hernández Eva , González-García Vicente , Palacio-Bielsa Ana , Lorenzo-Vidal Belén , Buzón-Durán Laura , Martín-Gil Jesús , Martín-Ramos Pablo
Published: April 2023

Phytopathogenic bacteria represent a risk to global food production by impacting a variety of crops. The aim of this study was to characterize the contents of bioactive constituents in extracts from Ginkgo biloba L. leaves and fruits and test their activity against six phytopathogenic bacteria that affect horticultural crops. Gas chromatography–mass spectrometry (GC−MS) was used for the chemical profiling of the aqueous methanol extracts, and their bacteriostatic activity against Clavibacter michiganensis subsp. michiganensis, Pseudomonas cichorii, Pseudomonas syringae pv. pisi, Pseudomonas syringae pv. syringae, Pseudomonas syringae pv. tomato, and Xanthomonas vesicatoria (formerly Xanthomonas campestris pv. vesicatoria) was determined in vitro through the agar dilution method. The protective effect of the leaf extract was tested in vivo against the most relevant bacterial pathogens based on their economic/scientific importance, i.e., C. michiganensis subsp. michiganensis and P. syringae pv. pisi, in tomato (Solanum lycopersicum L.) and pea (Pisum sativum L.) plants, respectively, under greenhouse conditions. The GC−MS characterization of G. biloba extracts revealed the presence of dihydro-4-hydroxy-2(3H)-furanone, 2,4-dimethyl-3-hexanol, catechol, 3-O-methyl-D-fructose, 4,6-di-O-methyl-α-D-galactose, methyl 2-O-methyl-α-D-xylofuranoside, and 3-methyl mannoside. In vitro growth inhibition tests showed that, while the fruit extract had no activity, the leaf extract exhibited minimum inhibitory concentrations between 500 and 1000 μg mL−1, which may be attributed to the presence of 2,4-dimethyl-3-hexanol and catechol. In vivo tests of the leaf extract demonstrated full protection in tomato and pea plants at 1000 and 1500 μg∙mL−1, respectively. The results indicate that G. biloba leaves may be employed as a biorational source for integrated pest management in horticulture.
The Effectiveness of Online Mental Health First Aid Training in Community Rugby: A Mixed-Methods Approach
Authors: Russell Suzanna , Kelly Vincent , Polman Remco , Warren-James Matthew
Published: April 2023

Mental Health First Aid (MHFA) training exists to improve supportive behaviours towards peers, increase mental health literacy, and reduce stigma. Community sport clubs have potential to successfully deliver mental health programs. This study investigated the effectiveness of online MHFA training undertaken by members of the rugby community and evaluated the feasibility and usefulness of the online delivery mode and users’ engagement with it. A mixed-methods approach was used to provide depth of understanding through qualitative analysis, combined with quantitative outcomes. Online surveys examining participants’ knowledge and perceptions were administered pre- and post-MHFA training. Significant improvements (p < 0.05) across all assessed domains were observed post- compared to pre-MHFA training. A large effect size was identified in relation to advice giving and sign and symptom identification. A moderate effect size pre- to post-improvement was identified for users’ perceptions of therapy’s effectiveness, the ability of people with severe mental health conditions to recover, and benefit of a healthcare professional. Participants endorsed the MHFA program to improve mental health literacy, advance non-technical skills, and improve confidence. MHFA training can increase the awareness and knowledge of mental health issues in key individuals in community sport clubs and enable them to aid people with mental health concerns. Online MHFA training is associated with improved mental health literacy and may be a suitable and economically sustainable model for community sport.
Transport Channels of Air Pollutants Affecting the Southern Sichuan Basin Based on Gridded Dispersion Simulation
Authors: Mo Yinpeng , Shi Guangming , Jiang Xia , Luo Tianzhi , Zhou Shuhua , Yang Fumo
Published: April 2023

Air pollutants suspended in the atmosphere have a large impact on air quality, climate, and human health. As one of the important populated and industrialized regions in China, the Sichuan Basin (SCB) has confronted severe air pollution in recent years. Previous studies have shown that regional transport played a significant role in the formation of regional pollution in the SCB, particularly in the southern basin. Using Yibin and Zigong as representative receptor cities, we further identified the transport channels affecting the southern basin by conducting gridded dispersion simulations. A total of seven channels were identified, including three for cyclonic transport, three through the mountainous areas between the Longquan Mountain and the Huaying Mountain, and one along the Yangtze River. Varying seasonal distributions of their occurrence frequencies were observed. Furthermore, observational evidence for several universal channels was presented during a typical transport case. The transport pathways identified in this study can guide the planning of regional distribution of emission sources and the measures for regional joint prevention and control of air pollution.
Prevention Aiming at Functioning—Describing Prevention in the Context of Rehabilitation: A Discussion Paper
Authors: Gutenbrunner Christoph , Nugraha Boya , Meyer Thorsten
Published: April 2023

The widely accepted model of prevention, including primary, secondary and tertiary prevention, focuses predominantly on diseases. The WHO provides a comprehensive model of health conceptualized on the basis of the International Classification of Functioning, Disability and Health (ICF). This paper develops a conceptual description of prevention aimed at functioning on the basis of the ICF model. Starting from the ICF-based conceptual descriptions of rehabilitation as a health strategy, a conceptual description of functioning prevention has been developed. Prevention aiming at functioning is the health strategy that applies approaches to avoid or reduce risks of impairing bodily functions and structures, activity limitations and participation restrictions; to strengthen the resources of the person; to optimize capacity and performance; to prevent impairments of bodily functions and structures; to prevent activity limitations and participation restrictions; to reduce contextual risk factors and barriers, including personal and environmental factors; to promote and strengthen contextual facilitators, with the goal of enabling people with impairments and people at risk of disability; and to maintain or improve the level of functioning in interactions with the environment. The proposed concept widens the scope of prevention to all aspects of functioning, including contextual factors.
The Role of Diet and Specific Nutrients during the COVID-19 Pandemic: What Have We Learned over the Last Three Years?
Authors: Rust Petra , Ekmekcioglu Cem
Published: April 2023

Nutrients and diets have an important impact on our immune system and infection risk and a huge number of papers have been published dealing with various aspects of nutrition in relation to SARS-CoV-2 infection risk or COVID-19 severity. This narrative review aims to give an update on this association and tries to summarize some of the most important findings after three years of pandemic. The analysis of major studies and systematic reviews leads to the conclusion that a healthy plant-based diet reduces the risks for SARS-CoV-2 infection and especially COVID-19 severity. Regarding micronutrients, vitamin D is to the fore, but also zinc, vitamin C and, to some extent, selenium may play a role in COVID-19. Furthermore, omega-3-fatty acids with their anti-inflammatory effects also deserve attention. Therefore, a major aim of societal nutritional efforts in future should be to foster a high quality plant-based diet, which not only exerts beneficial effects on the immune system but also reduces the risk for non-communicable diseases such as type 2 diabetes or obesity which are also primary risk factors for worse COVID-19 outcomes. Another aim should be to focus on a good supply of critical immune-effective nutrients, such as vitamin D and zinc.
Characteristics of Pressure on the Apophysis in the Course of Paediatric Heel Pain—Preliminary Report
Authors: Bitenc-Jasiejko Aleksandra , Walińska Anna , Konior Krzysztof , Gonta Kinga , Skomro Piotr , Kijak Konrad , Kowacka Małgorzata , Lietz-Kijak Danuta
Published: April 2023

Increased pressure on the heel apophysis is often implicated as a cause of paediatric heel pain. However, there are few reports on the causes of the increased pressure and its origin. Therefore, the aim of this study was to analyse the distribution of pressure on the feet in children with heel pain. The study included 33 paediatric patients with non-traumatic heel pain, i.e., 24 boys (73%) and 9 girls (27%), aged on average 11.2 years (±3 years). Pedobarographic diagnostics proved a decrease in the pressure on the heels in relation to the ground and the transfer of the projection of the centre of gravity to the forefoot. While standing, the average contribution of the pressure on the heel was 0.52, SD = 0.14 in children with normal and reduced weight. In overweight children, the average pressure on the heel was higher (0.60, SD = 0.08), but the small number of children with this characteristic (n = 4) did not allow conclusions to be drawn in this area. Heel underload was also demonstrated during gait. However, the assessment of this aspect requires additional observational analyses in the field of propulsion and gait phases. The reduced pressure on the heel promotes apophysis traction, causing intracanal compression. Studies have shown that the causes of apophysis traction may be postural defects (in particular, forward inclination of body posture) and overpronation of the foot, or defects in the metatarsal area.
Persistence of Immune Response Elicited by Three Doses of mRNA Vaccine against SARS-CoV-2 in a Cohort of Patients with Solid Tumors: A One-Year Follow-Up
Authors: Lasagna Angioletta , Cassaniti Irene , Arena Francesca , Bergami Federica , Percivalle Elena , Comolli Giuditta , Sarasini Antonella , Ferrari Alessandro , Cicognini Daniela , Schiavo Roberta , Lo Cascio Giuliana , Pedrazzoli Paolo , Baldanti Fausto
Published: April 2023

The role and durability of the immunogenicity of the BNT162b2 mRNA vaccine against severe acute respiratory virus 2 (SARS-CoV-2), in cancer patients one year after receiving the third dose have to be elucidated. We have prospectively evaluated the long-term immunogenicity of the third dose of the SARS-CoV-2 BNT162b2 mRNA vaccine in 55 patients undergoing active treatment. Neutralizing antibody (NT Ab) titers against Omicron variants and total anti-trimeric S IgG levels were measured one year after the third dose. Heparinized whole-blood samples were used for the assessment of the SARS-CoV-2 interferon-γ release assay (IGRA). Thirty-seven patients (67.3%) showed positive total anti-trimeric S IgG one year after the third dose. Looking at the T-cell response against the spike protein, the frequency of responder patients did not decrease significantly between six and twelve months after the third dose. Finally, less than 20% of cancer patients showed an undetectable NT Ab titer against BA.1 and BA.5 variants of concern (VOCs). Underlying therapies seem to not affect the magnitude or frequency of the immune response. Our work underlines the persistence of humoral and cellular immune responses against BNT162b2 in a cohort of cancer patients one year after receiving the third dose, regardless of the type of underlying therapy.