bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of the Potential Impact of Industry 4.0 Technologies on the Levers of Lean Manufacturing in Manufacturing Industries in Morocco
Authors:   Industrial Management and Plastics Forming Technology Team. Mechanics, Engineering and Innovation Laboratory, LM2I - ENSEM- Hassan II University Casablanca, Morocco, Ghouat Mohammed , Benhadou Mariam , Benhadou Basma , Haddout Abdellah
Published: July 2022

To increase their productivity, industrial companies are investing in the implementation of the Lean Manufacturing (LM) approach. Based on an analysis of the value chain, the approach reduces waste between the different production processes. The scope of this concept remains limited because it is based on static data. The technologies of the industry 4.0 concept allow the collection of data in real time. In this article, we present the results of a study conducted among companies in the automotive industry based in Morocco, in order to assess the level of deployment of the technologies of the 4.0 industry concept, and then analyze the impact of these technologies on the levers and key performance indicators of the Lean manufacturing approach. We have highlighted the technologies that have the most impact, namely: ERP, machine-to-machine communication (M2M communication), AIDC (Automatic Identification and Data Capture) and data analysis. The most impacted performance indicators are: Cycle Time, Takt Time, Lead Time and OEE.
Design of Taiwan High Speed Rail's Emergency Measures Using Petri Nets
Authors:   epartment of Electrical Engineering, National Kaohsiung University of Science and Technology, Kaohsiung 80778, Taiwan., Wang Tai Chun , Ching Huang Jong , Liang  Pan Yen , Yi Tian Mau
Published: July 2022

Nowadays, high-speed trains (HST), called highspeed rail (HSR), are considered more energy-efficient or equivalent to other modes of transit per passenger mile. One main factor is that due to infrastructure design in many countries, highway and air travel systems are constrained, cannot expand, and are often overloaded. Based on the above situations, Taiwan High-Speed Rail (THSR) started being built in 2000 and started running in 2007, respectively. However, Taiwan is located in the Eurasian seismic zone, and many earthquakes occur every year. Undoubtedly, how to take correct emergency measures in THSR has become very important. It would cause incredible results if the emergency measure cannot efficiently and be fast enough to let every support units take their position, disperse the crowd and repair the rail immediately. Therefore, this paper tries to design the data flow of THSR's emergency measure using Petri nets. The final simulation results reveal that the proposed model is deadlock-free and practical.
Performance Evaluation of Energy Harvesting Method on Intelligent Wearable Travel Aid Device for Blind Person
Authors:   Centre of Excellence for Robotic, and Industrial Automation (CERIA), Rehabilitation and Assistive Engineering Technology Research Group (REAT), Faculty of Electrical Engineering, Universiti Teknikal Malaysia Melaka, Hang Tuah Jaya, Durian Tunggal, 76100 Melaka, MALAYSIA, Kassim A. M. , Ayub N. N. , Shukor A. Z. , Abid M. A. A , Jaya A. K. R. A. , Yasuno T.
Published: July 2022

The intelligent wearable travel aid device has been developed for blind person usage for traveling purposes. The intelligent wearable travel aid device will be used along with the long cane that is usually used to detect any obstructions around the blind person. However, the problem on power supply to supply the electrical energy for the intelligent wearable travel aid device to work properly always been occurred. In order to fit the energy harvesting device on the intelligent wearable travel aid device, the comparison of the solar panel and photodiode is done. The performance evaluation to compare theenergy harvesting method on the developed intelligent wearable travel aid device for blind person has been conductedbased on the experiment result. The photodiode is proposed in this study due to small size and easy to arrange on top of developed wearable travel aid device compared to the solar panel which big size but commonly used as energy harvesting device. Consequently, the experimental result of the intelligent wearable travel aid device in terms of voltage, current and light intensity for the improved version with different type of configuration is proven respectively.
Zero Trust Architecture: Trend and Impact on Information Security
Authors:   uburn University at Montgomery, Department of Information Systems Alabama, United States, EDO Onome Christopher , Tenebe Theophilus , Etu Egbe-etu , Ayuwu Atamgbo , Emakhu Joshua , Adebiyi Shakiru
Published: July 2022

Traditional-based security models are a threat to information security; they have been regarded as weak and ineffective to meet the dynamics of information system trust. An emerging framework, Zero Trust Architecture (ZTA) seeks to close the trust gap in information security through enforcing policies based on identity and continuous authentication and verification. This framework is built on several trust nodes and logical components that attempt to close the trust gap that exists in an information system. The adoption of this framework is still in its teething stage which is a result of several misleading deductions and assumptions. We attempt to explore the intricacies in the framework and close the existing knowledge gap. we surveyed the literature on ZTA and provided a foundational discussion on its implementation and effectiveness from prior studies. while we do not critique other models, this paper studied the strength and variables of the zero-trust security architecture and attempt to provide an overview of the model and close the knowledge gap on the effectiveness of adopting a Zero trust philosophy.
Use of Blockchain Based Techniques in Healthcare: A Study
Authors:   Amity School of Engineering & Technology, Department of Computer Science & Engineering, Amity University Rajasthan, Jaipur, India, Deshmukh Varun , Pathak Sunil , Bhattacharya Pronaya
Published: July 2022

Blockchain is among the most significant discoveries and innovative trend that plays a critical role in the professional world today. Blockchain will redesign the way patients' electronic health records. Patient’s health records are shared, pre-served and secured in distributed peer-to-peer network in healthcare industries. A systematic organized analysis was undertaken to analyse the Blockchain and healthcare literature to further encourage understanding of Blockchain technologies and to recognize current issues and unanswered questions. This paper's vital contribution is to incorporate preliminary findings from a study of different applications in different areas on the implementation of Blockchain.
Private and Public in Surveillance Capitalism
Authors: Peša Anita
Published: July 2022

The paper deals with the protection of the private and public spheres in surveillance capitalism. Predictions on consumer behaviour or the so-called behavioural surpluses are extracted from the set of collected (big) data of users/consumers from the so-called digital footprints, which become intelligence data, commodities on the data market. In addition to predicting user behaviour, various behavioural techniques push, or nudge users in a particular desired consumer or political direction or action, or dark nudge techniques when it comes to unauthorized data collection on users in the digital sphere. Surveiling and nudging users is done in the range from caring for their health, well-being and benefits, as well as general and public well-being, to encouraging expenditure, desired behaviour or voting in the desired direction of subjects who create such incentives (corporations, political parties, governments, etc.). The subject of the paper is based on behavioural economics which has introduced behavioural techniques in the field of public policy. The author proposes conceptual model of protective and active approach in the era of surveillance capitalism in the private and public spheres. An overview of the current digital regulation in the EU is given, and the need for further development of the legislative framework that will regulate the issues of supervision and protection of privacy and user data is pointed out.
Cultures of Care
Authors: Chamberlayne Prue , King Annette
Published: July 2022

Cultures of Care uses an innovative biographical case study approach to compare caring situations and caring strategies in Britain and East and West Germany. The findings underline the significance of caring within social policy agendas and the need to change the parameters of comparative social policy.
Business Strategy Analysis of Cocoa Agribusiness Commodity Export Company at Agro Tama
Authors: Hapsari Marina Diah , Munizu Musran , Munir Abdul Razak
Published: July 2022

Cocoa, which is known as one of the people's plantations, is one of the commodities that has a positive contribution during the Covid-19 pandemic. The positive results of macro data related to the contribution of agriculture, especially cocoa to Indonesia's income during the pandemic, in fact experienced problems in raw materials which experienced a gradual decline in productivity in recent years, and also affected the productivity of several domestic cocoa companies. The decline in raw materials and the COVID-19 pandemic that has occurred since the end of 2019 also added to other problems faced by agricultural commodity export companies, including Agro Tama. Agro Tama is a domestic export company located in Makassar City which has been established for more than 20 years and contributes to the Indonesian economy through the export of cocoa beans. This study aims to analyze the company's internal and external factors, namely Strength, Weakness, Opportunity and Threat to produce an alternative strategy that is right for the company's condition. The results of the SWOT analysis show that the company's condition is in quadrant III strategy, namely WO (Weakness Opportunity) and produces 4 alternative strategies which are then analyzed again using the Analytical Hierarchy Process model. The results of the AHP analysis resulted in a proposed priority strategy, namely optimizing the company's export commodity diversification, with the main objective of the analysis model being the company's business development during the pandemic with a weight of 0.303.
Encouraging MSME Growth by Improving Financial Literature and Financial Inclusion in Sanur Kauh Village Community
Authors: Sawitri Ni Putu Yuliana Ria , Sudiyani Ni Nyoman , Putri I Gusti Agung Prabandari Tri , Putri Cokorda Istri Agung Vera Nindia , Geriadi Made Ayu Desy
Published: July 2022

Financial literacy has become a hotly discussed issue in recent years in Indonesia. The issues that arise cannot be separated from various polemics that have occurred, ranging from the Asean Economic Community (MEA) to the economic crisis that hit Indonesia in 1998. At this time financial literacy is an important thing and a necessity for the wider community, the public is required to know and understand financial literacy. The low level of public knowledge about the financial industry and its products causes people to be easily trapped in making investments that offer lucrative returns in the short term without considering the risks. This causes harm to the community itself. The government and financial institutions need to seek an understanding of financial literacy for the Indonesian people. One of the efforts to increase financial literacy is education related to legal investment through Community Service conducted by the Faculty of Economics and Business, Ngurah Rai University together with the Regional VIII Bali and Nusa Tenggara Financial Services Authority and the Bali Regional Development Bank for the community of Sanur Kauh Village.
Clustering Fiscal Management Behavior at Local School Districts: The Case of Local Education Finance
Authors:   The Korean Society For The Economics And Finance Of Education, Shim MinKyung , Han Juhi , Chung Il Hwan
Published: July 2022

There are growing concerns about efficient fiscal management and expenditure structure due to the decline of the school-age population, the expansion of educational autonomy, and the increase of block grant in education finance. The local education financial analysis system has been developed to fulfill fiscal responsibility and evaluate the efficiency and performance of fiscal management, but research on the operational performance and development potential of this system is insufficient. This study analyzed the financial soundness and financial efficiency index of the local school district based on the financial index of the local education finance analysis system through cluster analysis, a machine learning unsupervised learning approach. A result of the analysis reveals that heterogeneous clustering by financial indicators of local education offices was found, and this offers implications on how policy can be improved such as simplification of financial analysis indicators and data-based decision-making was presented.
An empirical analysis on the relationship between college students’ satisfaction on college efforts for student support and student withdrawal
Authors:   The Korean Society For The Economics And Finance Of Education, Kim Young-sik , Lee Hojun
Published: July 2022

The purpose of this study is to empirically investigate the relationship between college students’ satisfaction on college efforts for student support and students’ withdrawals. To achieve the goal, this study exploits 4th year dataset of KEEP II utilizing logit and fixed/random effect logit model.
The results of this study first show that students’ satisfaction on education and welfare facilities is positively related to the reduction of student withdrawal. Based on this result, we can conclude that facility improvement and space innovation for students are needed to curtail student withdrawal. Meanwhile, this study also finds that students’ satisfaction on psychological counselling and career/ employment/entrepreneurship services are not statistically related to students withdrawal.
The results suggest that it is needed to evaluate overall performance of student support services and to endeavor to improve the performance with further studies regarding this issue.
Understanding How Postnatal Depression Screening and Early Intervention Works in the Real World – A Singaporean Perspective
Authors: Lee Theresa MY , Bautista Dianne , Chen Helen Y
Published: July 2022

Postnatal depression is a major public health problem with clearly established adverse effects in child outcomes. This study examines the 4-year outcomes of a screening and early intervention programme, in relation to improvement in symptoms, functioning and health quality of life. Women were prospectively recruited up to 6 months postdelivery, using the Edinburgh Postnatal Depression Scale (EPDS) as a screening tool. High-scorers (EPDS >13), were offered psychiatric consultation, and those with borderline scores (EPDS 10-12) were provided counselling, and offered follow-up phone counselling by the assigned case manager. Outcome measures were obtained at baseline, and at 6 months or discharge if earlier, for levels of symptoms, functioning, and health quality of life. From 2008 to 2012, 5245 women were screened, with 307 (5.9%) women with EPDS >13 receiving intervention. Of these, 70.0% had depression, 4.6% anxiety and 3.4% psychosis. In the depression subgroup, the net change was improvement of 93.4% EPDS symptom scores, 92.2% Global Assessment of Functioning (GAF) scores, and 88.3% visual analogue scale (EQ VAS) health quality of life scores. Outcome scores across diagnostic categories demonstrated median changes of 10 points on EPDS, 20 points on GAF, and 25 points on EQ VAS, reflecting 73.9%, 36.4% and 41.7% change from baseline scores. Women with psychosis showed the biggest (80.0%) relative change in GAF functioning scores from baseline to discharge but had the lowest median change in EPDS symptom scores. A screening and intervention programme rightly-sited within an obstetric setting can improve clinical outcomes because of early detection and intervention.

Key words: Early detection, Maternal mental health, Postpartum mood
Prevalence and Risk Factors of Caregiver Dependence among Older Adults in a Southeast Asian Population
Authors: Picco Louisa , Abdin Edimansyah , Vaingankar Janhavi A , Pang Shirlene , Shafie Saleha , Sambasivam Rajeswari , Chong Siow Ann , Subramaniam Mythily
Published: July 2022

Introduction: Currently very little is known about the prevalence or magnitude of caregiver dependence in Singapore and thus, there is a need to fill this gap in this multiethnic ageing population. This study aims to determine the prevalence and risk factors of caregiver dependence among older adults in Singapore. Materials and Methods: Data were used from the Well-being of the Singapore Elderly (WiSE) study, a nationally representative, cross-sectional survey among Singapore residents aged 60 years and above. Caregiver dependence was ascertained by asking the informant (the person who knows the older person best) a series of open-ended questions about the older person’s care needs. Results: The older adult sample comprised 57.1% females and the majority were aged 60 to 74 years (74.8%), while 19.5% were 75 to 84 years, and 5.7% were 85 years and above. The prevalence of caregiver dependence was 17.2% among older adults. Significant sociodemographic risk factors of caregiver dependence included older age (75 to 84 years, and 85 years and above, P <0.001), Malay and Indian ethnicity (P <0.001), those who have never been married (P = 0.048) or have no education (P = 0.035), as well as being homemakers or retired (P <0.001). After adjusting for sociodemographic variables and all health conditions in multiple logistic regression analyses, dementia (P <0.001), depression (P = 0.011), stroke (P = 0.002), eyesight problems (P = 0.003), persistent cough (P = 0.016), paralysis (P <0.001), asthma (P = 0.016) and cancer (P = 0.026) were significantly associated with caregiver dependence. Conclusion: Various sociodemographic and health-related conditions were significantly associated with caregiver dependence. Dependent older adults will put greater demands on health and social services, resulting in greater healthcare expenditures. Hence, effective planning, services and support are crucial to meet the needs of dependent older adults and their caregivers.

Key words: Epidemiology, Multiethnic, Singapore
Characteristics and Risk Factors for Mortality in Paediatric In-Hospital Cardiac Events in Singapore: Retrospective Single Centre Experience
Authors: Mok Yee Hui , Loke Amanda PT , Loh Tsee Foong , Lee Jan Hau
Published: July 2022

Introduction: There is limited data on paediatric resuscitation outcomes in Asia. We aimed to describe outcomes of paediatric in-hospital cardiac arrests (IHCA) and peri-resuscitation factors associated with mortality in our institution. Materials and Methods: Using data from our hospital’s code registry from 2009 to 2014, we analysed all patients younger than 18 years of age with IHCA who required cardiopulmonary resuscitation (CPR). Exposure variables were obtained from clinical demographics, CPR and post-resuscitation data. Outcomes measured were: survival after initial CPR event and survival to hospital discharge. We analysed categorical and continuous variables with Fisher’s exact and Wilcoxon rank-sum tests respectively. Statistical significance was taken as P <0.05. Results: We identified 51 patients in the study period. Median age of patients was 1.9 (interquartile range [IQR]: 0.3, 5.5) years. Twenty-six (51%) patients had bradycardia as the first-recorded rhythm. The most common pre-existing medical condition was respiratory-related (n = 25, 48%). Thirty-eight (75%) achieved sustained return of spontaneous circulation, 24 (47%) survived to paediatric intensive care unit (PICU) discharge and 23 (45%) survived to hospital discharge. Risk factors for hospital mortality included: age, duration of CPR, adrenaline, calcium or bicarbonate administration during CPR, Paediatric Index of Mortality (PIM)-II scores, first recorded post-resuscitation pH and hyperglycaemia within 24 hours of resuscitation. Conclusion: We demonstrated an association between clinical demographics (age, PIM-II scores), CPR variables (duration of CPR and administration of adrenaline, calcium or bicarbonate) and post-resuscitation laboratory results (first recorded pH and hyperglycaemia within 24 hours) with PICU survival. The availability and quality of post-resuscitation care may have implications on survival after paediatric IHCA.

Key words: Cardiopulmonary resuscitation, Child, Infant
Anaphylaxis in Children: Experience of 485 Episodes in 1,272,482 Patient Attendances at a Tertiary Paediatric Emergency Department from 2007 to 2014
Authors: Ganapathy Sashikumar , Lwin Zaw , Ting Daniel HA , Goh Lynette SH , Chong Shu-Ling
Published: July 2022

Introduction: Anaphylaxis is a predominantly childhood disease. Most of the literature on anaphylaxis has emerged from Western countries. This study aimed to describe the incidence, triggers and clinical presentation of anaphylaxis among children in Singapore, look for predictors for anaphylaxis with severe outcomes, and study the incidence of biphasic reactions. Materials and Methods: We retrospectively reviewed records of children presenting with anaphylaxis to our paediatric emergency department from 1 January 2007 to 31 December 2014. Results: We identified 485 cases of anaphylaxis in 445 patients. Cutaneous symptoms (urticaria/angio-oedema) were the most common across all age groups (481 cases, 99%), followed by respiratory (412, 85%), gastrointestinal (118, 24%) and cardiovascular (35, 7.2%) symptoms. Central nervous system symptoms (drowsiness/irritability) were rare across all age groups (11, 2.2%). Food was identified as the most common trigger across all age groups (45% to 63%). Seafood was the most common food trigger (57, 25%). A total of 420 (86.6%) children were treated with adrenaline, 451 (93%) received steroids and 411 (85%) received antihistamines. Sixty-three (13%) children fulfilled the criteria of severe anaphylaxis.There was no statistically significant association between severe anaphylaxis and the type of trigger (P = 0.851), nor an overall past history of atopy (P = 0.428). The only independent predictor for severe anaphylaxis was a previous drug allergy (P = 0.016). A very low prevalence of biphasic reactions (0.6% of study population) was noted in our study. Conclusion: We described the presentation and management of anaphylaxis in the Singapore population. A history of drug allergy is associated with severe presentation. Biphasic reactions are rare in our population.

Key words: Allergy, Angioedema, Hypotension, Paediatrics
Disability in Singapore’s Elderly Population
Authors: Mahesh Mithila , Abdin Edimansyah , Vaingankar Janhavi Ajit , Picco Louisa , Jeyagurunathan Anita , Binte Shafie Saleha , Pang Shirlene , Sagayadevan Vathsala , Seow Esmond , Chong Siow Ann , Subramaniam Mythily
Published: July 2022

Introduction: Disability increases an individual’s dependence and negatively impacts their physical, mental, and social functioning. The current study aims to establish the prevalence and risk factors of disability in Singapore’s population. Materials and Methods: Data was extracted from the Well-being of the Singapore Elderly (WiSE) study. This cross-sectional study recruited participants aged 60 years and above (n = 2421) who were representative of Singapore’s multiethnic population. We used the World Health Organization Disability Assessment Schedule (WHODAS) 2.0 to assess the severity of disability in our sample while establishing its associations and correlations with cognitive levels, sociodemographic variables, and chronic illness. Results: Cognitive deficits, old age, female gender, Malay and Indian ethnicity, lack of education, retired or homemaker status, presence of chronic illness (specifically stroke, heart problems, depression, and dementia) were found to be significantly associated with disability in Singapore’s elderly population. As hypothesised, participants with deficits in cognition were more likely to indicate higher WHODAS scores. Conclusion: The findings highlighted specific factors associated with disability in this multiethnic population. The identification of these factors would lead the way to the development of appropriate interventions.

Key words: Chronic illness, Cognitive decline, Functioning, Old age
Evaluation of Efficacy of Chloroquine for Plasmodium Vivax Infection Using Parasite Clearance Times: A 10-Year Study and Systematic Review
Authors: Subramony Hariharan , Tangpukdee Noppadon , Krudsood Srivicha , Poovorawan Kittiyod , Muangnoicharoen Sant , Wilairatana Polrat
Published: July 2022

Introduction: Chloroquine, in combination with primaquine, is used as the firstline treatment for uncomplicated P. vivax malaria in Thailand. In view of the declining efficacy of chloroquine in many P. vivax endemic areas, the possibility of emergence of chloroquine-resistant P. vivax in Thailand is a concern. The aim of this study was to assess the trends in therapeutic efficacy of chloroquine and primaquine for the treatment of uncomplicated P. vivax malaria and to assess the utility of parasite clearance times as a measure of efficacy. Materials and Methods: This study consisted of: 1) review of medical records of patients who were hospitalised for a period during their treatment for uncomplicated P. vivax malaria at the Hospital for Tropical Diseases, Bangkok, Thailand between 2004 and 2013. Treatment consisted of chloroquine (1500 mg base administered over 3 days) or chloroquine (as before) plus primaquine (15 to 30 mg base/daily for 14 days from day 2); and 2) systematic review of the literature in English to assess current standards in the reporting of parasite clearance times. Results: The 28-day cure rate was 99.1%. The range of median parasite clearance time over the 10-year period was 46 to 59 hours, and there was statistical evidence for an increasing trend in parasite clearance times between 2009 and 2013. Heterogeneity was noted among previous chloroquine efficacy studies in the measurement and reporting of parasite clearance. Conclusion: The treatment of P. vivax infection with a combination of chloroquine and primaquine has remained efficacious in Thailand. Increasing rates of parasite clearance in a population over time may be a useful early warning mechanism for the emergence of chloroquine resistance. The utility of monitoring time-trends in parasite clearance to detect resistance may be enhanced if parasite clearance measurements are standardised.

Key words: Vivax malaria, Parasite clearance rates, Chloroquine resistance, Time-trends
Impact of Direct Cardiovascular Laboratory Activation by Emergency Physicians on False-Positive Activation Rates
Authors: Tay Julian CK , Lun Liou Wei , Liang Zhong , Chua Terrance SJ , Lim Swee Han , Wong Aaron SL , Ong Marcus EH , Ho Kay Woon
Published: July 2022

Introduction: Door-to-balloon (DTB) time is critical to ST elevation myocardial infarction (STEMI) patients’ survival. Although DTB time is reduced with direct cardiovascular laboratory (CVL) activation by emergency physicians, concerns regarding false-positive activation remain. We evaluate false-positive rates before and after direct CVL activation and factors associated with false-positive activations. Materials and Methods: This is a retrospective single centre study of all emergency CVL activation 3 years before and after introduction of direct activation in July 2007. False-positive activation is defined as either: 1) absence of culprit vessel with coronary artery thrombus or ulceration, or 2) presence of chronic total occlusion of culprit vessel, with no cardiac biomarker elevations and no regional wall abnormalities. All false-positive cases were verified by reviewing their coronary angiograms and patient records. Results: A total of 1809 subjects were recruited; 84 (4.64%) identified as false-positives. Incidence of false-positive before and after direct activation was 4.1% and 5.1% respectively, which was not significant (P = 0.315). In multivariate logistic regression analysis, factors associated with false-positive were: female (odds ratio (OR): 2.104 [1.247-3.548], P = 0.005), absence of chest pain (OR: 5.369 [3.024-9.531], P <0.0001) and presence of only left bundle branch block (LBBB) as indication for activation (OR: 65.691 [19.870-217.179], P <0.0001). Conclusion: Improvement in DTB time with direct CVL activation by emergency physicians is not associated with increased false-positive activations. Factors associated with false-positive, especially lack of chest pain or LBBB, can be taken into account to optimise STEMI management.

Key words: Cardiac, Catheterisation
Quality of Life in Obstructive Sleep Apnoea: A Role for Oxygen Desaturation Indices?
Authors: Huang Wenjie , Rangabashyam Mahalakshmi , Hao Ying , Liu Jiaying , Toh Song Tar
Published: July 2022

Introduction: This study aimed to determine the impact of obstructive sleep apnoea (OSA) on quality of life (QOL) and evaluate the utility of polysomnographic parameters in reflecting QOL. Materials and Methods: Eighty-eight patients who underwent polysomnography (PSG) between December 2010 and November 2012 consecutively were recruited and they completed the 36-Item Short-Form Health Survey (SF-36) and Epworth Sleepiness Scale (ESS) questionnaires. Based on the apnoea-hypopnoea index (AHI), patients were classified as primary snorers (AHI <5), suffering from mild (5 ≤15), moderate (15 ≤30) or severe OSA (≥30). Results: Seventy-nine male and 9 female patients with a mean age of 41 years were recruited. OSA patients scored significantly lower on 7 domains of SF-36 compared to the population. As AHI increased, only Physical Function (PF) and Physical Component Summary (PCS) but not ESS scores significantly worsened. PSG parameters correlated poorly with all QOL measures except PF, PCS and ESS. After adjusting for age, sex and body mass index (BMI), multiple linear regression revealed that only the oxygen desaturation parameters, but not sleep architecture indices or AHI were significant predictors of PF and ESS. For every fall in the lowest oxygen saturation (LSAT) by 1%, there was a decrease in PF by 0.59 points, and an increase in ESS by 0.13 points. Conclusion: OSA patients have a poor QOL compared to the population. The amount of physical impairment and daytime sleepiness they experience is better predicted by severity and duration of hypoxia and not AHI.

Key words: Apnoea-hypopnoea index, Polysomnography, Sleep-disordered breathing
Vermicomposting in Silver Oak Plantation Areas for Sustainable Waste Management and Enhanced Livelihood: A Case Study of Kolli Hills, Tamil Nadu, India
Authors:   Associate Professor of Economics, Indraprastha College for Women, University of Delhi, Delhi, India., Saha Anindita Roy
Published: July 2022

Silver Oak plantation on farmlands growing coffee and black pepper has gained importance in recent times in the areas surrounding the Kolli hills in the Namakkal district of Tamil Nadu, India. The Silver Oak trees shed significant quantities of dry leaves during the summer season which the local Malayali tribal community burns and/or leaves on ground. The current case study is based on an experiment of vermicomposting using local Silver Oak leaf litter, cow dung and earthworms. The results show that joint production of manure from agroforestry practices is an option in self-sufficiency for the rural communities and has the potential for a business model. Moreover, this ensures environmental sustainability by avoiding green-house gas emissions that are caused by the practice of burning leaves and/or leaving the mulch to rot. The present paper attempts to develop a sustainable model of vermicomposting in the Kolli hills region that can offer triple solutions encompassing organic manure production, environmental quality improvement and livelihood opportunity enhancement. Based on field surveys and physiochemical experiments in the Perungiraipatti village of the Kolli hills, the study presents a sustainable model of vermicomposting with specifications on nutritional quality, environmental sustainability and economic development.
A NOVEL ANALYTICAL APPROACH FOR SOLVING TIME-FRACTIONAL DIFFUSION EQUATIONS
Authors:   Department of Mathematics, University of Rajasthan, Jaipur, Rajasthan-302004, India., Bairwa R.K.
Published: July 2022

This article investigates the approximate analytical solutions of the time-fractional diffusion equations using a novel analytical approach, namely the Sumudu transform iterative method. The time-fractional derivatives are considered in the Caputo sense. The analytical solutions are found in closed form, in terms of Mittag-Leffler functions. Furthermore, the findings are shown graphically, and the solution graphs demonstrate a strong relationship between the approximate and exact solutions.
Analisis Diversifikasi, Merger, dan Akuisis Perusahaan
Authors: Warti Risma , Dara Audina Dea , Azizi Adelia
Published: July 2022

This research aims to analyze the diversification, mergers and acquisitions of manufacturing companies in Indonesia. The research method used is descriptive qualitative analysis with a literature study approach. The results show that the diversification analysis was developed with various objectives including increasing growth when the existing market/product has reached a maturity stage, maintaining stability by spreading the risk of profit fluctuations, increasing credibility in the capital market, to avoid dependence on a single item or product in circulation. in the market, fulfill the wishes of unsatisfied consumers, increase the attractiveness or interest of consumers, increase sales turnover, increase profits by using the same ingredients, and prevent consumer boredom.

Keywords: Diversification, Mergers, and Company Acquisitions.
A Systematic Review on Pharmacological Actions of Ficus hispida
Authors: D. K. Anvitha , M. Ashoka Shenoy , Hegde Karunakar , Shabaraya A. R.
Published: July 2022

Ficus hispida is commonly known as Hairy fig. It is a shrub or tree mainly found throughout India and also in parts of China, Sri Lanka, Australia and Myanmar. Various parts of Ficus hispida like leaf, bark, stem, root, leaves, fruits and also latex is used for medicinal purpose. Different extracts of Ficus hispida have been investigated for pharmacological actions such as anti-inflammatory, antineoplastic, hepatoprotective, anticonvulsant, anti-ulcer activities. Phyto constituents such as terpenoids, flavonoids, alkaloids, sterols and glycosides present in Ficus hispida contribute to these activities. Ficus hispida is rich in pharmacological activities and is used as traditional medicine from ancient times. This review article aims to discuss morphology, phytochemistry and pharmacological actions of Ficus hispida.
Role of Coformers in Solubility Enhancement of Poorly Soluble Drugs through Cocrystallization: An Overview
Authors: R Hema , N S Ganesh , Chandy Vineeth
Published: July 2022

Improving the solubility of poorly soluble pharmaceuticals is a key problem in the pharmaceutical industry, and it can be solved using a range of methods, such as particle size reduction, surface modification, and other procedures. Cocrystallization is a new method for enhancing solubility in the pharmaceutical industry, which can be done with the help of cocrystal former (Coformer). These are water- soluble stoichiometric cocrystals of the active pharmaceutical ingredient (API) with water-soluble small molecule coformers such as ascorbic acid, Nicotinamide etc. Selection of coformer is a principal challenge in evolution of cocrystals, which can be done by various approaches such as trial and error, supra molecular synthon, virtual screening, etc. Hydrogen bonding, halogen bonding, and π-π interactions all play a part in the development of cocrystals. Moisture absorption, cocrystal reactant dissolution, cocrystal nucleation, and growth are all factors that impact crystal formation. Cocrystals can be prepared by various methods such as Solution evaporation method, Solution cooling crystallization, Solid state grinding, Liquid assisted grinding method, Hot melt extrusion, etc. This review complies the various research works on cocrystals.
Stability Indicating RP-HPLC Method for the Estimation of Selumetinib in Capsule Dosage Form
Authors: Saindane Kamlesh Kashinath , Talapadatur Harshada , Munipalli Vijay Kumar , Singh Raman Mohan , Fegade Bharti , Bhaskar Vaidun
Published: July 2022

The principal objective of this study is to develop and validate a new, simple, accurate, fast, economical, precise, and reproducible Reverse Phase High-Performance Liquid Chromatography (RP-HPLC) for the estimation of selumetinib in a capsule dosage form. The chromatographic separation was performed on the Inert Sustain C18 (250 mm × 4.6 mm i.d., 5 μm particle size) column and a mobile phase comprising of 0.1 % Trifluoroacetic acid in Water and Acetonitrile in the ratio of (60:40 % v/v) was used. The diluent consisting of water and acetonitrile in the ratio of (50:50 % v/v) was used. The flow rate was kept at 1.1 ml/min and detection was carried out at 258 nm. The retention time of selumetinib was found to be about 5.9 min. The parameters such as accuracy, precision, linearity, ruggedness, robustness and LOD, LOQ were used for validating the developed method according to ICH guidelines. The method was linear over a concentration range of 50-175 μg/ml with a regression coefficient of 0.9998. Limit of Detection and Limit of Quantitation values for selumetinib was found to be 0.15 μg/ml and 0.47 μg/ml, respectively. The percentage RSD of every parameter was found within the limit. The stress testing studies were executed to give degradation products by exposing the drugs to hydrolytic, photolytic, oxidative, acid, alkali, and thermal degradation conditions. The acquired data showed that the degradation product successfully separated without any intrusion, which establishes the stability-indicating nature of a developed method. The accurate, simple, precise, economical, reliable, and easy for RP-HPLC method has been successfully developed and validated. The developed method was applied for routine quality control analysis of selumetinib in capsule dosage forms.
Comparative Study of Efficacy and Safety of Tamsulosin plus Tadalafil Combination Therapy versus Tamsulosin Monotherapy as Medical Expulsive Therapy of Ureteric Stone
Authors: Kumar Arun , Hameed Saajid , Kumar Manish , Mohan Lalit , Kumar Vijoy , Dikshit Harihar
Published: July 2022

Introduction: If surgical intervention is not indicated, current international guidelines and evidences recommend medical expulsive therapy (MET) involving the administration of drugs to improve spontaneous stone passage. Medical expulsive therapy has now become an established modality of treatment, and employs the use of various drugs that act on the ureter with different mechanisms. It is hypothesised that elevation of cyclic guanosine monophosphate in ureteral smooth muscle by phosphodiesterase type 5 (PDE5) inhibitors may result in ureteral relaxation and increased stone clearance. Aims/ objective: To investigate whether we can achieve better ureteric relaxation and reduction in intramural pressure in order to facilitate stone passage by tamsulosin plus tadalafil combination therapy. Materials and Method: Stone expulsion rate of tamsulosin + tadalafil when compared to tamsulosin was our primary endpoint. (Assessed by subjective response and confirmed by repeat plain X ray abdomen and if needed CT scan abdomen). The efficacy of the individual drugs was analysed and compared with the help of Pearson chi square test. p value <0.05 were considered as statistically significant. Results: 33 patients (66%) receiving tamsulosin and 43 patients (86%) receiving combination therapy showed positive outcome (expulsion of stones). So, tamsulosin plus tadalafil combination therapy had significantly better efficacy. In tamsulosin group 30 patients among 33 (90.9%) expelled the stone in less than 5 days. In tamsulosin plus tadalafil group, 37 patients among 43 (86%) expelled in less than 5 days. But the difference was not statistically significant. Both drugs were well tolerated by the study patients. Conclusion: Tamsulosin plus tadalafil is more efficacious, and well tolerated as medical expulsive therapy for distal ureteric stones compared to tamsulosin. Medical expulsive therapy also doesn’t carry post-operative morbidities as compared to surgical methods.
Фактическое питания и пищевой статуса у мужчин с ожирением
Authors: Шайхова Гули , Иброхимова Дилобар , Зокирхонова Шахзода , Шайхова М
Published: July 2022

Ожирение – хроническое рецидивирующее заболевание, сегодня является один из самых распространенных неинфекционных заболеваний: в 1998 г. в мире зарегистрировано 250 млн. больных ожирением, а к 2025 г., по расчету экспертов ВОЗ их число превысит 300 млн.Целью данной работы явилось изучение фактического питания и пищевого статуса, а также физической активности мужчин с ожирением. Материалы и методы. Обследовано 250 мужчин в возрасте от 40 до 55-летнего возраста, с диагнозом ожирение 1-11 и 111 степени, проживающих в г.Ташкенте и Ташкентской области. 30 мужчин составили контрольную группу. Исследование проводили в клинике Levelmed г.Ташкента.
Кредит-модуль тизимида мустақил таълимни ташкил этиш тамойиллари
Authors: Тошматов Гуломжон , Даминова Гулмира
Published: July 2022

Мақолада кредит-модуль тизими ва унинг тарихи, унинг афзаллиги, турлари, хорижий мамлакатларда ва мамлакатимизда қандай жорий этилиши, ECTS кредит тизими, академик кредит, академик модуль, талабанинг мустақил таълими(ТМИ), ўқитувчи раҳбарлигида талаба-нинг мустақил таълими (ЎРТМИ) ва унинг таркибий элементлари, талабаларнинг тасдиқланган шахсий ўқув режалари ҳақида маълумотлар берилган.
Понятие и сущность цифровизации в правовой сфере Республики Узбекистан
Authors: Тагаева Нигора
Published: July 2022

Данная статья приводит доводы о первых признаках цифровизации в истории человечества. Дает разъяснения понятию цифровизации. Широко освещает сведения о внедрении информационно-коммуникационных технологий в правовые сферы Республики Узбекистан. Разъясняет значение цифровизации в сфере защиты прав.
O IMAGINÁRIO ORIENTALISTA NOS RELATOS DE VIAGEM DE PABLO NERUDA
Authors: Loureiro Isabela Roque , Azevedo Suzana de Carvalho Barroso , Dazzi Camila Carneiro
Published: July 2022

Este artigo propõe-se a investigar os relatos de viagem do escritor chileno Pablo Neruda no início do século XX, quando vivencia sua carreira diplomática no exterior. Nosso objetivo é analisar esses textos buscando identificar as (des) continuidades de um Oriente místico, exótico e pitoresco, fruto de um imaginário construído no século XIX, sobretudo pela arte e pela literatura. Para tanto, valemo-nos de conceitos como imaginário, definido como um acervo coletivo de sentidos que motiva a ação, bem como do entendimento de relato de viagem como um gênero subjetivo, impressionista e de natureza, muitas vezes, política. As análises apontam para uma percepção híbrida e não idealizada de Neruda em relação ao Oriente, composta por construções orientalistas de singular beleza assim como por uma visão negativa, possivelmente derivada de sua experiência como um cidadão de um país que também teve a história marcada pelo processo de colonização. Dessa maneira, os relatos nerudianos transgridem a lógica hegemônica não só por terem sido escritos por um viajante de origem não europeia, mas também por subverterem um imaginário colonial sobre o Oriente, construído em um contexto de dominação violenta.
O ETHOS PELA HOMONÍMIA
Authors: Kristensen de Camargo Amanda , Paulo Bini Renan
Published: July 2022

Neste artigo, objetiva-se analisar o ethos das personagens Germán, Alfonso, Álvaro e Gabriel, da obra ficcional Cem anos de solidão (MÁRQUEZ, 2009), homônimas do grupo de intelectuais de Barranquilla citados na autobiografia Viver para Contá-la (MÁRQUEZ, 2003): Germán Vargas, Alfonso Fuenmayor, Álvaro Cepeda Samudio e Gabriel García Márquez, cujo comportamento social é sumarizado pela ficção. Para isso, propõe-se uma ponte teórico-analítica entre categorias específicas de duas áreas do conhecimento: o ethos discursivo, da Retórica; e a homonímia e a onomatomância, da Onomástica. Neste estudo, a homonímia e a onomatomância foram consideradas agentes cooperativos para a construção de determinados ethé ficcionais. Por meio da comparação da construção dos homônimos presentes na obra ficcional e na autobiografia de Márquez pôde-se realizar associação das identidades das personagens aos entes reais (segundo a perspectiva de Márquez), e explicitar o elo imagético e argumentativo presente nos fenômenos homonímico e onomatomântico, sendo passível de descrição, ainda, a perspectiva identitário-psicológica de tais fenômenos, principalmente a partir da memória subterrânea em La masacre de las bananeras, partilhada por ente ficcional - Gabriel - e autor - Gabriel García Márquez.
AS MEMÓRIAS DE UMA MESTIZA EM BORDERLANDS/LA FRONTERA
Authors: Martins dos Santos Ana Carolina
Published: July 2022

Este artigo busca investigar a relação entre língua e memória na (re)construção da identidade do sujeito transfronteiriço a partir de uma análise comparatista crítica da obra Borderlands/La frontera: La nueva mestiza (2016) de Gloria Anzaldúa. Interessa discutir de que modo a memória se constitui como elemento basilar na (re)construção identitária, frente a uma realidade entre línguas/mundos, em uma obra translíngue. A respeito do conceito de translinguismo, são utilizadas as considerações teóricas de Megale Siano e Esteves de Camargo (2015), Pratt (2011) e González Palmero (2019). Com relação às ponderações teóricas sobre memória e identidade, estão as discussões e análises de Assmann (2011), Candau (2011) e Ricoeur (2007). Desse modo, pretende-se compreender a relação que se estabelece entre língua-memória na constituição da identidade desse sujeito transfronteiriço.
DESDOBRAMENTO DA AUTOBIOGRAFIA EM HETEROBIOGRAFIA
Authors: Carvalho do Carmo Mirella , Portolomeos Andréa
Published: July 2022

Este artigo pretende discutir a estreita e conflituosa relação entre autobiografia e poesia em poemas da trilogia Boitempo, de Carlos Drummond de Andrade. A temática mostra-se significativa para a problematização de uma leitura mais ingênua que busca as razões do poema na esfera extraliterária, isto é, na vida do poeta, assim como para uma compreensão mais ampla sobre o sujeito lírico como um complexo elemento ficcional. Para isso, este trabalho baseia-se nas concepções teóricas de Hoisel (2019), Lejeune (2014), Arfuch (2010), Smith (1971) e Iser (1996, 2002), debatendo sobre o espaço autobiográfico na poesia e sobre uma recepção mais astuciosa da lírica memorialística de Drummond. O artigo discute, ainda, com o aporte de Halbwachs (1990), Silva (2009), Miranda (1988) e Santiago (2008, 2004), o ingrediente coletivo das memórias e a ressemantização do sujeito na ficção. As análises dos poemas dialogam com o suporte crítico de Candido (2000), Villaça (2006) e Pedrosa (2011) e visam esclarecer como os textos memorialísticos de Drummond propõem a recriação do passado de um “eu” que se reconhece como “outro” e projeta-se no “outro”, sendo constantemente coescrito no ato da leitura.