bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding students’ academic help-seeking on digital devices – a qualitative analysis
Authors: Schlusche Christian , Schnaubert Lenka , Bodemer Daniel
Published: February 2023

Undergraduate students are expected to regulate their learning processes and overcome knowledge-related obstacles. Academic help-seeking (HS) is a social strategy to acquire missing information or explanations. As mobile devices are a popular means for communication between students, services on those devices are of interest for computer-mediated academic HS. The goal of the presented study is to determine requirements for the design of digital services that support asking for and receiving help. The article presents students’ perspectives on the knowledge-related obstacles that cause them to seek help through computer-mediated communication via mobile devices. Moreover, it presents respondents’ perceived inhibitions about asking peers for help. Finally, the perceived technical drawbacks of popular services are outlined. Data acquired from N = 59 semi-structured interviews were analyzed using qualitative content analysis. The students reported that they experience knowledge-related obstacles while working on assignments and that they avoid HS when they are worried about social humiliation. They also reported that a messenger service was used most frequently for HS. The results are valuable for designers and practitioners in the field of computer-mediated academic HS.
Cognitive and affective effects of teachers’ annotations and talking heads on asynchronous video lectures in a web development course
Authors: Garcia Manuel B. , Yousef Ahmed Mohamed Fahmy
Published: February 2023

When it comes to asynchronous online learning, the literature recommends multimedia content like videos of lectures and demonstrations. However, the lack of emotional connection and the absence of teacher support in these video materials can be detrimental to student success. We proposed incorporating talking heads and annotations to alleviate these weaknesses. In this study, we investigated the cognitive and affective effects of integrating these solutions in asynchronous video lectures. Guided by the theoretical lens of Cognitive Theory of Multimedia Learning and Cognitive-Affective Theory of Learning with Media, we produced a total of 72 videos (average = four videos per subtopic) with a mean duration of 258 seconds (range = 193 to 318 seconds). To comparatively assess our video treatments (i.e., regular videos, videos with face, videos with annotation, or videos with face and annotation), we conducted an educational-based cluster randomized controlled trial within a 14-week academic period with four cohorts of students enrolled in an introductory web design and development course. We recorded a total of 42,425 total page views (212.13 page views per student) for all web browsing activities within the online learning platform. Moreover, 39.92% (16,935 views) of these page views were attributed to the video pages accumulating a total of 47,665 minutes of watch time. Our findings suggest that combining talking heads and annotations in asynchronous video lectures yielded the highest learning performance, longest watch time, and highest satisfaction, engagement, and attitude scores. These discoveries have significant implications for designing video lectures for online education to support students’ activities and engagement. Therefore, we concluded that academic institutions, curriculum developers, instructional designers, and educators should consider these findings before relocating face-to-face courses to online learning systems to maximize the benefits of video-based learning.
Interest-Driven Creator Theory: case study of embodiment in an experimental school in Taiwan
Authors: Looi Chee-Kit , Wong Su Luan , Kong Siu-Cheung , Chan Tak-Wai , Shih Ju-Ling , Chang Ben , Wu Ying-Tien , Liu Chen-Chung , Yeh Charles Y. C. , Chen Zhi-Hong , Chien Tzu-Chao , Chou Chih-Yueh , Hung Hui-Chun , Cheng Hercy , Liao Calvin C. Y.
Published: February 2023

Cognisant that the examination-driven culture in most Asian schools will hinder future educational innovation, a group of concerned Asian researchers started collaboration in 2014 to develop a theory to serve as a guide to design interest- driven learning activities. This endeavour then spawned the development of the Interest-Driven Creator (IDC) Theory. The theory postulates that when their learning is driven by interest, students can be engaged in knowledge creation. The continued practice of this creation process in their daily learning routines can lead students to excel in learning performance, develop 21st century competences and eventually form creation habits to be lifelong learners. This paper, therefore, adds on to the current articulation of IDC Theory by highlighting the implementation of an IDC experimental school in Taiwan and by presenting the story of how it embodies the spirit of IDC. The school curriculum prepares students to be lifelong readers and reflective writers with broad knowledge in the fields of Math, English Language, Science, and Interdisciplinary Social Studies. It emphasises not only students’ academic growth but also their physical wellness and character building. The endeavour intends to be a comprehensive example of practice-driven research, demonstrating how theory and practice can be bridged, and how a virtuous cycle of research improving practice and practice informing research can be developed. This paper also provides a glimpse of how IDC Theory can inspire the planning and integration of IDC-based education approaches in academic curricula beyond Taiwan. The paper ends with the call for a more concerted effort to create a sustainable alliance to share professional insights into IDC Theory through a non- governmental organisation.
Exploratory Model of Violence in The Era of Covid-19
Authors: García Lirios Cruz
Published: February 2023

The mitigation of the pandemic, social distancing and confinement, transferred workplace violence to the domestic space, diversifying the differences between the parties involved. The objective of this paper is to explore this structure of domestic and workplace violence, reported in the media and in the specialized literature. A non-experimental, cross-sectional and exploratory study was carried out with a selection of 100 students from a public university in central Mexico. The results show that organizational violence would be made up of eight factors: prejudice, depersonalization, benevolence, harassment, submission, objectification, stigma and harassment, which show the limits of the study and research guidelines in terms of equity.
Neurocognitive sequelae following COVID-19 infection in older adults with and without pre-infection neurocognitive impairment
Authors: J. Liu Andy
Published: February 2023

In this case report,we describe the clinical characteristics of three older adults aged >65years with cognitive difficulties prior to theirCOVID-19 infection who reported worsening of neurocognitive symptoms in the convalescent COVID-19 phase. Formal neuropsychological testingalong with neuroimaging were included with each patient. These patients described an initial worseningin cognitive functionafter recovering from the acute phase of COVID19. This case reportdescribes variable recoveryof cognitive abilities in the convalescent stage. The direct effectof the viral infection itselfon cognitive function are well documented. We hypothesize that the persistent inflammatory or immune response in the convalescent COVID-19 stage, more commonly referred to as the indirect mechanism, contributes to the clinical syndromeknown as the Post-Acute Sequelae of SARS-CoV-2 (PASC).
Level of Stress, Anxiety, Depression, and Resilience for Social Workers During Covid 19 Pandemic in Kosovo
Authors: Bojaxhiu Huçaj Behare
Published: February 2023

In January 2020, the WHO declared the outbreak of Coronavirus as a Public Health Emergency of international importance, the same happened in Kosovo. Public health actions, such as social distancing, isolation can make people feel lonely and can increase stress and anxiety. This research aims to show the relationship between stress, anxiety, depression, and the development of resilience of social workers in the period of pandemics. DASS will be used to measure S.A.D (Lovibond, SH & Lovibond, 1995) and the ARM to measure resilience (Ungar, 2008,2011). It is hypothesized that S. Workers who have developed resilience will easily cope with S.A.D, while workers who failed to develop resilience will be more vulnerable to S.A.D. Participants are 39 social workers of CSW Pristina. The findings of the study show that the level of SAD is toa moderate extent and the level of resilience is high.
KHẢO SÁT MÃ VẠCH ADN, ĐẶC ĐIỂM THỰC VẬT, CHIẾT XUẤT VÀ ĐỊNH TÍNH TINH DẦU CỦA CÂY KHUYNH DIỆP SỪNG CAO-HỌ SIM (MYRTACEAE)
Authors: Lý Hồng Hương Hạ , Võ Thị Bích Ngọc , Trần Trung Trĩnh , Nguyễn Thế Nhựt , Dương Nguyên Xuân Lâm
Published: February 2023

Đặt vấn đề: Lá của cây Khuynh diệp sừng cao được dùng trị cảm sốt, đau đầu, đau dạ dày, ăn không tiêu, phong thấp ở Trung Quốc, nhưng có ít các nghiên cứu đã được công bố. Mục tiêu nghiên cứu: Khảo sát mã vạch ADN, đặc điểm thực vật để góp phần định dạng đúng loài Khuynh diệp sừng cao; Chiết xuất và định tính tinh dầu bằng sắc ký khí. Đối tượng và phương pháp nghiên cứu: Cây Khuynh diệp sừng cao tươi được thu thập tại Trà Vinh, được phân tích, mô tả, chụp ảnh các đặc điểm hình thái, giải phẫu và bột dược liệu, kèm phân tích ADN lục lạp vùng ITS1. Chiết xuất tinh dầu. Phân tích thành phần tinh dầu trong lá bằng sắc ký khí. Kết quả: Loài Khuynh diệp sừng cao được định danh dựa trên hình thái và mã vạch ADN xác định tên khoa học là Eucalypstus tereticornis J. E. SM., kèm dữ liệu giải phẫu, bột vi học, hàm lượng tinh dầu và các thành phần trong tinh dầu. Kết luận: Nghiên cứu góp phần cung cấp dữ liệu định danh chính xác loài Khuynh diệp sừng cao và các cấu tử trong tinh dầu.
NGHIÊN CỨU ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VIÊM TAI GIỮA CẤP TRẺ EM VÀ ĐÁNH GIÁ KẾT QUẢ ĐIỀU TRỊ PHẪU THUẬT NỘI SOI ĐẶT ỐNG THÔNG KHÍ MÀNG NHĨ TẠI CẦN THƠ NĂM 2020-2022
Authors: Trương Lê Anh Kiệt , Phạm Thanh Thế , Nguyễn Kỳ Duy Tâm
Published: February 2023

Đặt vấn đề: Hình thái lâm sàng viêm tai giữa cấp ngày nay đã biến đổi rất nhiều nên người thầy thuốc rất dễ bỏ sót các triệu chứng kín đáo, âm thầm ở trẻ em. Nhĩ lượng đồ là một phương pháp khách quan giúp ta đánh giá những tổn thương tai giữa trong viêm tai giữa cấp. Phẫu thuật đặt ống thông khí nhằm dẫn lưu dịch mủ, khôi phục lại sự thông khí của hòm nhĩ, giảm bớt các đợt viêm tai giữa cấp tái diễn và đưa kháng sinh tại chỗ giúp điều trị viêm tai giữa cấp hiệu quả hơn. Mục tiêu nghiên cứu: Mô tả đặc điểm lâm sàng, cận lâm sàng viêm tai giữa cấp trẻ em, đánh giá kết quả điều trị phẫu thuật nội soi đặt ống thông khí màng nhĩ. Đối tượng và phương pháp nghiên cứu: 99 tai bị viêm tai giữa cấp được điều trị phẫu thuật nội soi đặt ống thông khí màng nhĩ, nghiên cứu mô tả tiến cứu có can thiệp, chọn mẫu thuận tiện. Kết quả: Đặc điểm lâm sàng: đau tai chiếm 87,7%, sốt 21,1%, triệu chứng thực thể: màng nhĩ phồng: 66,7%. Nhĩ lượng đồ: nhĩ đồ phẳng 81,8%. Thời gian khô tai: 2,1 tuần. Biến chứng sau đặt OTK: chảy tai (10.1%), tắc OTK (1%). Kết luận: Phẫu thuật đặt ống thông khí qua màng nhĩ là phẫu thuật rất hiệu quả trong điều trị viêm tai giữa cấp.
ĐÁNH GIÁ KIẾN THỨC VỀ 5S VÀ MỘT SỐ YẾU TỐ LIÊN QUAN ĐẾN KIẾN THỨC THỰC HÀNH 5S TẠI BỆNH VIỆN ĐA KHOA THÀNH PHỐ CẦN THƠ NĂM 2021
Authors: Lâm Hữu Đức , Trần Thanh Trí , Nguyễn Hoàng Thiên Thư
Published: February 2023

Đặt vấn đề: Phương pháp quản lý 5S là một hình thức quản lý trực quan có hệ thống, không chỉ đề cập đến sự sạch sẽ của tổ chức mà còn là sự tối đa hóa của hệ thống và lợi nhuận. Bệnh viện Đa khoa thành phố Cần Thơ hiện đang triển khai hệ thống quản lý chất lượng, kiến thức 5S của nhân viên y tế (NVYT) còn chưa được đánh giá. Mục tiêu nghiên cứu: Đánh giá về kiến thức 5S và một số yếu tố liên quan đến thực hành 5S của (NVYT) tại Bệnh viện Đa khoa thành phố Cần Thơ. Đối tượng và phương pháp nghiên cứu: Nghiên cứu thực hiện trên 96 NVYT hiện đang làm việc tại Bệnh viện Đa khoa thành phố Cần Thơ vào tháng 6/2021; nghiên cứu mô tả cắt ngang, lấy mẫu toàn bộ. Nghiên cứu sử dụng bảng kiểm 5S của tổ chức JICA gồm 37 nội dung và 6 mức điểm để đánh giá. Kết quả: Tỷ lệ NVYT có kiến thức đúng về 5S là 87,5%, cao nhất ở yếu tố sạch sẽ (90,63%) và thấp nhất sàng lọc (82,30%). Nam giới có số chênh về kiến thức 5S cao bằng 0,07 lần so với nữ giới; NVYT thuộc lĩnh vực hành chính có số chênh về kiến thức 5S cao bằng 0,23 lần so với đối tượng NVYT thuộc lĩnh vực khám chữa bệnh. Kết luận: Tăng cường phổ biến kiến thức về 5S cho NVYT, trong đó tập trung khâu Sàng lọc và nhóm NVYT thuộc lĩnh vực hành chính.
ĐÁNH GIÁ KẾT QUẢ ĐIỀU TRỊ THOÁT VỊ ĐĨA ĐỆM CỘT SỐNG CỔ BẰNG PHƯƠNG PHÁP CẮT ĐĨA, HÀN LIÊN THÂN ĐỐT LỐI TRƯỚC TẠI BỆNH VIỆN ĐA KHOA TRUNG ƯƠNG CẦN THƠ
Authors: Lâm Khải Duy , Nguyễn Hoàng Thuận , Nguyễn Thành Tấn
Published: February 2023

Đặt vấn đề: Thoát vị đĩa đệm cột sống cổ là bệnh lý do đĩa đệm cột sống cổ thoái hóa thoát vị, gây chèn ép tủy cổ hoặc rễ thần kinh. Phương pháp điều trị phẫu thuật lối trước lấy đĩa đệm hàn liên thân đốt sống bằng xương tự thân từ mào chậu là một tiêu chuẩn vàng trong điều trị thoát vị đĩa đệm. Mục tiêu nghiên cứu: Mô tả đặc điểm lâm sàng, cận lâm sàng và đánh giá kết quả điều trị thoát vị đĩa đệm cột sống cổ bằng phương pháp cắt đĩa, hàn liên thân đốt lối trước tại Bệnh viện Đa khoa Trung ương Cần Thơ năm 2021-2022. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 36 bệnh nhân thoát vị đĩa đệm cột sống cổ được phẫu thuật bằng phương pháp cắt đĩa, hàn liên thân đốt lối trước tại Bệnh viện Đa khoa Trung ương Cần Thơ từ tháng 02/2021 đến 11/2021. Kết quả: Bệnh nhân có hội chứng tủy gặp nhiều nhất (77,8%); hội chứng rễ thấp nhất (5,6%); hội chứng tủy-rễ (16,6%). Vị trí thoát vị: tầng C4-C5 nhiều nhất (44,4%), tầng C5-C6 (36,1%). Mức độ phục hồi độ ưỡn cột sống sau mổ là 80,1%. Tỷ lệ phục hồi R-R của thang điểm JOA: 88,24% đạt kết quả tốt và rất tốt, tạm chấp nhận 11,76%. Kết luận: Thoát vị đĩa đệm cột sống cổ được phẫu thuật cắt đĩa, hàn liên thân đốt lối trước giúp giải phóng chèn ép tuỷ và rễ thần kinh, với tỉ lệ phục hồi giải phẫu và chức năng rất cao, qua đó đem lại khả năng hoạt động bình thường cho bệnh nhân sau phẫu thuật.
Pengabdian kepada Masyarakat berupa Pendidikan Kesehatan Terkait Infeksi Saluran Pernapasan Akut (ISPA)
Authors: Suratmini Dwi , Jansen Susiana , Ardhiyanti Lusyta Puri
Published: February 2023

Infeksi Saluran Pernapasan Akut (ISPA) adalah penyakit paling menular di dunia. ISPA seringkali menyerang anak-anak, dimana ISPA menduduki 10 besar penyakit yang menjangkit anak-anak. Di Indonesia ISPA masih membutuhkan penanganan khusus. Penyuluhan berupa pendidikan kesehatan terkait ISPA di masyarakat diharapkan mampu meningkatkan pengetahuan masyarakat terkait ISPA serta mempengaruhi sikap masyarakat dalam pencegahan ISPA. Hasil dari kegiatan pengabdian kepada masyarakat di Puskesmas Cinere Kota Depok Jawa Barat ialah meningkatknya pengetahuan dan pemahaman masyarakat terkait ISPA mulai dari definisi, penyebab, klasifikasi, tanda gejala, factor risiko dan pencegahan terhadap ISPA.
Oral and peri-oral piercings: impact on the gingival tissues
Authors: O Halloran Apryl , MacCarthy Denise
Published: February 2023

##Introduction

Oral and peri-oral piercings have increased in popularity in recent years. As a result, general dental practitioners are more frequently seeing the destructive effects within the oral cavity. In this paper we will discuss two cases of gingival injury as a result of lip and tongue piercings, and their management.

##Discussion

The purpose of this paper is to highlight the potential negative effects of oral and peri-oral piercings, and the possible treatment options available, so that the dental team can discuss these with patients.

##Conclusion

These cases highlight the destructive effect of oral and peri-oral piercings on the gingival tissues, while demonstrating a treatment option to deal with gingival recession.
The impact of systemic conditions and polypharmacy on older patients’ oral health and dental treatment
Authors: Patton Barry , McPhillips Orla , Ní Ríordáin Richeal
Published: February 2023

Systemic diseases can affect people of any age, but they are much more common in the elderly population and are likely to become an increasingly prevalent issue as a progressively larger proportion of the population is aged over 65 years.

The effects of systemic diseases and their pharmacological management can have a multitude of oral presentations and impact on dentists’ ability to manage these patients’ oral health needs. This article discusses the effects of systemic diseases on the oral health of the elderly population, and how the general dentist can manage this patient cohort.
The Nature of Gender Portrayal in Editorial Cartoons: Analysis of Kenya’s Daily Nation and Standard Newspapers
Authors: Masinde Moses Wanyama , Lumala Masibo , Obuya Jared
Published: February 2023

Visual images often have lasting memory with the capacity to reveal the anguish of a tormented soul. It can stimulate sexual passion as well as generate intense feelings and excitement to the level of driving people to the bravery and barbaric acts.  These images evoke responses in people based on their interpretation of meanings informed by common beliefs and values. In most cases, the victims are subjected to gender-based humiliation in the public eye.  This paper investigates the nature of gender portrayal through selected editorial cartoons. This study is anchored on the relativist/interpretivist philosophical paradigm in which a qualitative case study design is adopted. The case in reference is the Daily Nation and the Standard newspapers of Kenya’s Nation Media Group and Standard Group, respectively. Data was generated from sampled cartoons published by the two dailies. The data was complemented by semi-structured in-depth interviews targeting the cartoonists, human rights activists, and gender specialists from selected organizations in Kenya. In total, 252 cartoons out of 2184 which is 11.5 percent, were sampled systematically through a six-week purposive sampling mechanism. Each week represented a month amounting to three years in a row. The findings of the study revealed that men were negatively represented in most of the cartoons. Specifically, men were linked to greed, corruption, political violence, and land grabbing among other issues. On the other hand, women were mostly portrayed as weak, helpless, vulnerable, and most afflicted. In over 30 of the sampled cartoons, women were projected as sexual objects and agents of beauty. And yet in some though only a few, the very women were projected as the voice of reason and one that could be entrusted with leadership and integrity. This study reveals the bias and increased stereotypical overtones and the inability of the two newspapers to adequately embrace gender sensitivity in the way cartoons portray both men and women to their readers. Editors, reporters, and cartoonists should remove bias and stereotypes in their portrayal of both men and women. To this end, urgent retraining and sensitization on gender sensitivity cartooning are highly recommended for media practitioners. Specific editorial guidelines for cartoonists and mentoring of female journalists to become cartoonists are equally required to mitigate biased cartooning.
Avrupa Birliği ve ASEAN Çerçevesinde Ekonomik Entegrasyonların Türkiye'nin Teknoloji Transferine Etkisi
Authors: Çakmaklı Bahadır Murat
Published: February 2023

Türkiye Cumhuriyeti kuruluşundan günümüze kadar içerde ve dışarda yaşamış olduğu acı tecrübeler sonrasında ekonomik kalkınmasını gelişmiş ülkeler seviyesine taşıyamadığı görülmektedir. Küreselleşmenin ülkelere dayattığı çıkmazlara karşı ayakta durabilmek adına teknolojik dönüşümün gerçekleştirmesi büyük önem taşımaktadır. Türkiye’de halen 2022 TÜİK rakamlarına göre yüksek teknoloji ihracatı %2.6 ile çok düşük seviyede olduğu görülmektedir. Bulunduğu coğrafya özelinde her konuda gelişmişlik göstermesi gereken Türkiye’nin bunu gerçekleştirirken ekonomik entegrasyonlar vasıtasıyla teknoloji transferini gerçekleştirmesi zaman ve maliyet açısından fayda sağlayacak ve nitelikli iş gücünün oluşması içinde zaman kazandıracaktır. Bu sebeple çalışmamızda ekonomik entegrasyonlar olarak AB ve ASEAN’ın Türkiye’nin gerçekleştireceği teknoloji transferine etkileri analiz edilerek, zaman ve maliyet açısından Türkiye’nin uygulayacağı politikaların belirlenmesi amaçlanmıştır. Böylece Türkiye’nin gelişmiş ülkeler liginde yer alması için hazırlanan samimi çalışmalarla birlikte literatürümüze katkı sağlayacağını düşünmekteyiz.
Turkey and the Future of Europe: A History
Authors: Casale Giancarlo
Published: February 2023

Throughout its history, Europe has never been simply a place but a complex set of ideas and aspirations in continual evolution—of which the European Union of 2022 is only the most recent iteration. As a result, while history cannot predict the future of Europe and its relationship to Turkey, what it can do is identify clearly recurrent patterns that are likely to continue. With this in mind, the present article provides a very long view—almost as old as history itself—of the evolution of the European idea as seen from Turkey, to provide a more rooted perspective on current debates about Turkey, Europe, and where the two are headed at a moment of dynamic change for both.
RESEACH ON THE RATE OF GLUCOSE -6-PHOSPHATE DEHYDROGENASE IN RBCS OF SOME ETHNICITIES IN THE NORTH OF VIETNAM
Authors: Nghiem Thi Thanh Nga , Dao Thi Mai Anh , Do Thi Tuyen
Published: February 2023

In the pentose phosphate pathway, glucose-6-phosphate dehydrogenase is an enzyme that helps red blood cells patients survive when they come into contact with oxidizing substances like oxygen, chemicals, or drugs. Glucose-6-phosphate dehydrogenase deficiency is an X-linked recessive genetic disorder brought on by gene mutations. The paper employs the formazan method to examine the prevalence of glucose -6-phosphate dehydrogenase deficiency in persimmons and its demand among different ethnic groups in the North of Vietnam.
KIỂM SOÁT QUYỀN LỰC NHÀ NƯỚC KHI THU HỒI ĐẤT THEO DỰ THẢO LUẬT ĐẤT ĐAI SỬA ĐỔI NĂM 2022
Authors: Phạm Thanh Nga
Published: February 2023

Hiện nay, Quốc hội đang lấy ý kiến của các tổ chức, cá nhân liên quan để hoàn thiện dự thảo và chuẩn bị ban hành Luật Đất đai sửa đổi. Trong bài viết này, tác giả phân tích sâu vấn đề kiểm soát quyền lực nhà nước khi thu hồi đất đai ở Việt Nam hiện nay. Từ đó, đề xuất các giải pháp để hoàn thiện hơn nữa pháp luật về đất đai khi tiến hành sửa đổi Luật Đất đai mới, nhằm bảo đảm quyền và lợi ích hợp pháp của cả nhà nước, doanh nghiệp và nhân dân trong thời gian tới.
NHÌN LẠI SỰ PHÁT TRIỂN CỦA KHOA HỌC GIÁO DỤC VIỆT NAM QUA CUỐN SÁCH “55 NĂM KHOA HỌC GIÁO DỤC VIỆT NAM: PHÂN TÍCH TỪ DỮ LIỆU SCOPUS”
Authors: Tạ Ngọc Thúy , Phạm Thị Oanh
Published: February 2023

Khoa học Giáo dục Việt Nam đã trải qua hơn 60 năm phát triển kể từ những nền móng đầu tiên khi Viện Nghiên cứu Giáo dục Việt Nam (nay là Viện Khoa học Giáo dục Việt Nam) được thành lập vào năm 1961. Trong suốt chiều dài đó, khoa học giáo dục Việt Nam đã có sự phát triển và hội nhập mạnh mẽ cùng với xu thế chung của nền khoa học Việt Nam. Cuốn sách “55 năm Khoa học Giáo dục Việt Nam: Phân tích từ dữ liệu Scopus” với sự hợp tác của Nhóm nghiên cứu Reduvation (Trường Đại học Thành Đô) và Trung tâm Nghiên cứu và Phát triển Giáo dục Edlab Asia vừa được Công ty cổ phần sách Omega Việt Nam xuất bản đã cung cấp tổng quan về sự phát triển Khoa học Giáo dục Việt Nam trong suốt chiều dài phát triển. Cuốn sách bao gồm hai chương chính với 132 trang đã cung cấp thông tin về khoa học giáo dục Việt Nam dựa trên những công bố quốc tế trong lĩnh vực này được chỉ mục trên cơ sở dữ liệu khoa học Scopus trong giai đoạn từ 1966 – 2020 thông qua phương pháp phân tích trắc lượng thư mục (bibliometric). Qua đó, nhóm tác giả đã giới thiệu về bức tranh phát triển của khoa học giáo dục Việt Nam như số lượng công bố, cộng đồng nghiên cứu, các nguồn tạp chí, mạng lưới hợp tác phát triển, các đơn vị nghiên cứu và các chủ đề, lĩnh vực nghiên cứu được các nhà khoa học giáo dục Việt Nam tập trung phát triển trong những năm qua. Phân tích trắc lượng thư mục là phương pháp được sử dụng rộng rãi trong trắc lượng khoa học. Phân tích trắc lượng thư mục giúp các nhà khoa học có thể phân tích được xu thế nghiên cứu của các lĩnh vực, so sánh sản phẩm khoa học giữa các nhóm nghiên cứu và các đơn vị khác.
BRINGING SPACE TECHNOLOGY TO MINING – BIOSENSORS FOR HEALTH MONITORING IN REAL TIME AS A MODERN MANAGEMENT PRACTICE
Authors:   University of Mining and Geology “St. Ivan Rilski”, Gicheva Gospodinka ,   Tokai University, Research Institute of Science & Technology, Hiratsuka city Kanagawa 259-1292, Japan, Chanachev Alexander ,   University of Mining and Geology “St. Ivan Rilski”, Kulinich Sergei ,   Tokai University, Research Institute of Science & Technology, Hiratsuka city Kanagawa 259-1292, Japan
Published: February 2023

Nowadays, mining industry is striving to be regarded as a modern and highly-technological field with no negative connotation to its name. The human factor is constantly increasing in significance, making mining industry more people oriented, and more and more efforts are being made to bring modern technologies into service and help create safer work environment. Utilising new types of biosensors provides remote health monitoring of workers in mining industry, thus enabling the real time monitoring of vitals of a person, permitting timely medical care and preventing long-term negative exposures. In this regard, the use of flexible, lightweight and wearable biosensors is seen as very convenient and patient-friendly in work environment without interfering with the daily activities. In this study we present a non-enzymatic glucose sensors based on ZnO nanoparticles prepared by a laser ablation in liquid method.
Peningkatkan Hasil Belajar Matematika Melalui Pendekatan Quantum Teaching
Authors: Idrus  , Nirmala Sri , Sardi Ahmed
Published: February 2023

Tujuan dari penelitian ini adalah untuk mengetahui Hasil belajar Matematika tentang hubungnan antar garis melalui pendekatan pembelajaran Quantum Teaching pada siswa kelas IVb SD Inpres Tantu tahun pelajaran 2019/2020. Penelitian ini merupakan Penelitian Tindakan Kelas (Classroom Action Research) dengan tahapan pelaksanaan meliputi: perencanaan, pelaksanaan tindakan, observasi, dan refleksi. Subjek penelitian ini adalah siswa kelas IVb SD Inpres Tantu kecamatan Duampanua Kabupaten Pinrang dengan jumlah siswa sebanyak 21 orang yang terdiri dari 8 laki-laki dan 13 Perempuan. Masing-masing siklus terdiri dari 4 tahapan adalah a) tahap perencanaan, b) tahap pelaksanaan tindakan, c) tahap observasi, dan d) tahap refleksi. Banyaknya siswa yang mencapai KKM Matematika pada siklus II ≥ 85% dari banyaknya siswa yang tuntas yaitu sebanyak 18 siswa atau 85.71% dari jumlak siswa yang ada sebanyak 21 siswa kelas IVb SD Inpres Tantu. Keaktifan siswa selama diterapkannya pendekatan pembelajaran Quantum Teaching meningkat, ditandai dengan adanya keseriusan dan perhatian siswa selama mengikuti proses belajar mengajar yang berlangsung.
Impact of Preparation Method in Co-Amorphous System
Authors: Soyata Amelia , Kenti Kenti , Sutoro Meylani , Sagita Novaliana
Published: February 2023

The co-amorphous solid dispersion system is one of the methods to improve the physicochemical characteristics and stability of a drug. With the appropriate material ratio and preparation method, a co-amorphous solid dispersion system can increase the bioavailability of the drug due to an increase in solubility. In addition, the co-amorphous system will maintain its amorphous shape longer than a single compound. However, using unsuitable materials and methods for co-amorphous fabrication will precipitate them and diminish their bioavailability. As a result, exploring the fundamentals of co-amorphous manufacturing methods is essential. This article discusses the physicochemical properties and solubility of co-amorphous mixtures prepared by solvent evaporation, milling, and quenching methods. Scopus, PubMed, and Google Scholar literature were obtained using the keywords 'co-amorphous preparation', 'co-amorphous method', 'solvent evaporation for co-amorphous preparation', 'milling methods for co-amorphous preparation', and 'quenching method for co-amorphous preparation'. We excluded literature whose application was not in the medical field. Based on the findings, the co-amorphous preparation methods have their respective advantages and disadvantages. Solvent evaporation can only be used on a small scale. Milling techniques are laborious and time-consuming but have a large yield and less chemical destruction, while the quenching method is only intended for thermostable compounds.
Pharmacophore Modeling and Molecular Docking of Flavonoid Derivatives in Abelmoschus manihot Against Human Estrogen Receptor Alpha of Breast Cancer
Authors: Patala Recky , Anggi Viani
Published: February 2023

Tamoxifen is the most commonly used anti-estrogen adjuvant therapy for estrogen receptor-positive breast cancer. However, it is associated with an increased risk of some serious side effects, such as uterine cancer, stroke, and pulmonary embolism. The flavonoid compounds in the leaves of A. manihot inhibited the growth of 4T1 breast cancer cells at a CTC50 concentration of 185.06 μg/ml. Therefore, this study aims to examine the molecular interactions and pharmacophore modeling based on the interaction of 4-OHT with human ER, followed by the molecular docking of the flavonoid derivatives with human ERα. The molecular docking simulations and 3D structure-based pharmacophore models were used to identify the molecular interactions of flavonoid derivatives in A. manihot on estrogen receptors (ERα) (PDB ID: 3ERT). The results showed that the binding energies of the flavonoid derivatives in isorhamnetin and isoquercitrin were -8.68 kcal/mol and -8.75 kcal/mol, respectively. This compound also interacted with Arg394 and Glu353 important amino acid residues in the ERα-binding pocket. Meanwhile, the pharmacophore fit scores of isorhamnetin and isoquercitrin were 82.36% and 84.91%, respectively. The flavonoid derivatives in A. manihot had pharmacophore fit resulting from the 4-OHT complex with ER, and therefore they had potential as ERα antagonists. Out of the 10 flavonoid derivatives, isorhamnetin and isoquercitrin showed the best docking scores and could be used as candidates for new anti-breast cancer drugs with antagonistic activity against ERα.
Randomized Open Clinical Trial to Evaluate Netratarpana Efficacy in Elderly Patients with Primary Insomnia (Anidra)
Authors: Kulkarni Satyajit , Chugule Pritam , Kulkarni Pallavi
Published: February 2023

Primary insomnia is the most prevalent health problem among the elderly in India. It is linked to musculoskeletal disorders, cardiac disorders, Chronic Obstructive Pulmonary Disease (COPD), depression, and schizophrenia. The incidence rate of primary insomnia among the elderly is 5%, and the prevalence rate is 20% or more. With an increase in the geriatric population, this prevalence rate will increase further. In Ayurveda, Netratarpana is described as a treatment modality for insomnia, but it was not studied yet. The study aimed to evaluate the efficacy of Netratarpana in Anidra (primary insomnia). In this RCT, 70 patients with Primary insomnia were randomly divided into two groups. In group A (n=35), Netratarpana was performed for 14 days, and group B (n= 35) was given Jatamansi powder 5 g at night with buffalo milk for 14 days as a comparison. The follow-up was taken on the 7th, 14th, and 21st day. The assessment was done using the Insomnia Severity Index (ISI) with the addition of Ayurvedic parameters. A total of 49 (70%) patients have an average age of 59.3 ± 3 years. There were 50 (71.4%) males and 20 (28.6 %) females. The sleep pattern was disturbed among 7 (10%), delayed among 19 (27.1%), and disturbed and delayed among 44 (62.9%). We found both Netratarpana and Jatamansi powder are effective in inducing sleep and preventing awakening during the night with a p-value of <0.05. It can be concluded that Netratarpana is effective in managing Anidra (primary insomnia), but the stability of the results needs to be confirmed by further study.
Pharmacological activities of bioactive compounds isolated from Acacia pennata (L) Willd: A comprehensive update and application of in-silico techniques for repurposing
Authors: Pegu Farida
Published: February 2023

Bioactive compounds (BACs) are naturally occurring compounds with pharmacological activities. BACs isolated from plants have significantly contributed to modern medicine. Multiple studies had reported the isolation of BACs with diverse pharmacological activities from Acacia pennata (L.) Willd. This review aims to compile all the available data on the pharmacological activities of the BACs that had been isolated from A. pennata. An online literature survey was carried out on academic databases namely Scopus, Science Direct, PubMed, and Google Scholar. Keywords such as ‘Acacia pennata’, ‘isolated compound’, and ‘pharmacological activity’ were used, either alone or in combination. A total of 52 articles published between the year 1980 to 2020 that contained relevant information on A. pennata were identified and collected. To date, a total of 29 compounds had been isolated from A. pennata. The compounds isolated from A. pennata belonged to secondary metabolites namely triterpenoid ketone, ceramide, alkaloid, saponin, flavonoid-glycoside, and terpenoid. A total of 22 BACs had been evaluated for biological activities such as anti-Alzheimer, anti-inflammatory, antioxidant, anti-diabetic, anti-obesity, anti-viral, anti-nociceptive, and anti-cancer activities. The pharmacological activities of 7 compounds isolated from A. pennata remained unexplored. A total of 14 compounds that had been isolated from A. pennata were also reported to be isolated from other plants. This comprehensive review provides an update on all the pharmacological works that had been carried out on the isolated BACs of A. pennata to date. In-silico techniques may be applied to repurpose the isolated BACs of A. pennata prior to wet lab studies.
In-silico study for African plants with possible beta-cell regeneration effect through inhibition of DYRK1A
Authors: Chikodili Igbokwe , Chioma Ibe , Chinwendu Nnorom , IfedibaluChukwu Ejiofor
Published: February 2023

The continuous destruction of normal insulin-producing pancreatic beta-cells is a contributing factor in all common forms of diabetes, due to insufficient production of insulin, especially in type 1 diabetes. There are attempts at beta-cells transplantation, but the cost and availability of donors pose a great challenge to the process. Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) plays a crucial role in beta-cells destruction. Our research targets to identify plants that can be utilized as a possible alternative approach to beta-cell replacement through a pharmacologically induced regeneration of new beta-cells in-silico. The 3D structure DYRK1A and 6511 phytochemicals were obtained from the Protein Data Bank and the African Natural Products Database respectively. They were duly prepared for molecular docking simulations (MDS). MDS was implemented, after validation of docking protocols, in AutoDock-Vina®, with virtual screening scripts. Phytocompounds with good binding affinities for DYRK1A were selected as frontrunners. The compounds were screened for toxicity, Lipinski’s rule confirmation with Data Warrior software followed by kinase inhibitory bioactivity prediction with the Molinspiration Chemoinformatics web tool. Twelve phytocompounds were found to be predictably highly active in-silico against DYRK1A with good drug-like property based on Lipinski’s rule, non-mutagenic, non-tumorigenic, no reproductive effect, and non-irritant, with high predicted bioactivity. In-silico active phytocompounds against DYRK1A with their plant sources and physicochemical parameters were identified. Further studies will be carried out in-vitro and in-vivo to validate the results of this study using plants containing the identified phytocompounds.
In-silico design and screening of cephalosporin derivatives for their inhibitory potential against Haemophilus influenza
Authors: Sangma Chikame , Chetia Dipak , Borthakur Malita , Patowary Lima , Tayeng Dubom
Published: February 2023

Antibiotics kill bacteria by blocking essential metabolic processes which prevent them from reproducing thereby allowing the immune system to fight bacterial infections. However, the emergence and the quick spread of bacterial resistance against clinically approved antibiotics have become alarming. This necessitates the development of novel treatment options and alternative antimicrobial therapies in the fight against bacterial infections. In this study, we aim to virtually design and carry out in-silico studies to identify a cephalosporin derivative with inhibitory potential against Haemophilus influenza. Data Warrior software, Discovery studio software, PyRx tool, Swiss ADME web tool, and ProTox-II web tool were used to screen the cephalosporin derivatives. Initially, 17 cephalosporin derivatives were preliminarily screened for their toxicity followed by in-silico ADME studies. Among the cephalosporin derivatives, C1, C6, and C12 were found to be the potential drug-like molecules with binding energies of -7.4 kcal/mol, -7.1 kcal/mol, and -7.1 kcal/mol, respectively. In particular, C1 was predicted to have a moderate biological activity with a high bioavailability score. Based on the ADME profile, toxicity, binding energy, drug-likeness, and drug score, we conclude C1 (‘F’ at the 3rd position) as the potential lead molecule to inhibit H. influenza.
An updated review of Rubus ellipticus (an edible shrub), its bioactive constituents and functional properties
Authors: Karn Abhishek , Quasim Md. , Hmar El Bethel , Paul Sujata , Sharma Hemanta
Published: February 2023

The vast majority of people continue to view medicinal plants as a low-cost source of medications and treatments. Numerous trees, herbs, plants, and shrubs have been used as remedies for various ailments since the dawn of time. Rubus ellipticus Smith, a weedy wild raspberry that flourishes in damp woods at high elevations, particularly those in the Himalayas and the Nilgiris area, is one of the important ethnomedicinal plants in the genus Rubus. Traditional Tibetan medicine places a great deal of importance on the plant R. ellipticus. Because of the abundance and diversity of phenolics and flavonoids in fruits or berries, which have a high concentration of both, they are generally regarded as inherently healthful foods. The roots and leaves, as well as the fruit, have traditionally been used as therapeutic agents for several illnesses including colic pain, gastrointestinal discomfort, wound healing, diarrhea, antifertility, antibacterial, analgesic, epilepsy, and others. The objective of the current review is to concentrate on the pharmacological characteristics, nutrition profile, phytoconstituents, and folkloric therapeutic applications of R. ellipticus, therefore achieving the review's overall subject.
Design and screening of tetracycline antibiotics: an in-silico approach
Authors: Barbhuyan Nahar , Tayeng Dubom , Gogoi Neelutpal , Patowary Lima , Chetia Dipak , Barthakur Malita
Published: February 2023

A prominent class of broad-spectrum antibiotics known as tetracycline works by inhibiting the synthesis of proteins, which prevents the development of bacteria. Tetracycline resistance is typically attributed to one or more of the following causes: ribosomal binding site mutations, acquisition of mobile genetic elements carrying tetracycline-specific resistance genes, and/or chromosomal mutations that increase the expression of intrinsic resistance mechanisms. In this research, our objective is to virtually plan and conduct in-silico experiments to find tetracycline derivatives with inhibitory capability against tetracycline resistance protein. The tetracycline derivatives were screened using the Data Warrior, Discovery Studio, PyRx, and Swiss ADME web tools. Initially, 19 tetracycline derivatives were primarily screened for ADME and toxicity study followed by docking study. Among the tetracycline derivatives, C1, C11, C12, C14, C16, and C17 were found to be the potential drug-like molecules with binding energies of -8.9 kcal/mol, -8.4 kcal/mol, -8.5 kcal/mol, -7.7 kcal/mol, -7.7 kcal/mol, -8.6 kcal/mol respectively. In particular, C1 was predicted to have a better binding affinity towards the target protein than the others.
Prevalent Pseudoprogression and Pseudoresidue in Patients With Rectal Cancer Treated With Neoadjuvant Immune Checkpoint Inhibitors
Authors: Xie Yumo , Lin Jinxin , Zhang Ning , Wang Xiaolin , Wang Puning , Peng Shaoyong , Li Juan , Wu Yuanhui , Huang Yaoyi , Zhuang Zhuokai , Shen Dingcheng , Zhu Mingxuan , Liu Xiaoxia , Liu Guangjian , Meng Xiaochun , Huang Meijin , Yu Huichuan , Luo Yanxin
Published: February 2023

Background: Immune checkpoint inhibitor (ICI) treatment in patients with microsatellite instability-high/mismatch repair deficient (MSI-H/dMMR) tumors holds promise in reshaping organ preservation in rectal cancer. However, the benefits are accompanied by distinctive patterns of response, introducing a dilemma in the response evaluation for clinical decision-making. Patients and Methods: Patients with locally advanced rectal cancer with MSI-H/dMMR tumors receiving neoadjuvant ICI (nICI) treatment (n=13) and matched patients receiving neoadjuvant chemoradiotherapy (nCRT; n=13) were included to compare clinical response and histopathologic features. Results: Among the 13 patients receiving nICI treatment, in the final radiologic evaluation prior to surgery (at a median of 103 days after initiation of therapy), progressive disease (n=3), stable disease (n=1), partial response (n=7), and complete response (n=2) were observed. However, these patients were later confirmed as having pathologic complete response, resulting in pseudoprogression and pseudoresidue with incidences of 23.1% (n=3) and 76.9% (n=10), respectively, whereas no pseudoprogression was found in the 13 patients receiving nCRT. We further revealed the histopathologic basis underlying the pseudoprogression and pseudoresidue by discovering the distinctive immune-related regression features after nICI treatment, including fibrogenesis, dense lymphocytes, and plasma cell infiltration. Conclusions: Pseudoprogression and pseudoresidue were unique and prevalent response patterns in MSI-H/dMMR rectal cancer after nICI treatment. Our findings highlight the importance of developing specific strategies for response evaluation in neoadjuvant immunotherapy to identify patients with a good response in whom sphincter/organ-preserving or watch-and-wait strategies may be considered.
Patient-Reported Outcome Measures in Chemotherapy-Induced Peripheral Neurotoxicity: Defining Minimal and Clinically Important Changes
Authors: Li Tiffany , Timmins Hannah C. , Trinh Terry , Mizrahi David , Harrison Michelle , Horvath Lisa G. , Grimison Peter , Friedlander Michael , Kiernan Matthew C. , King Madeleine T. , Rutherford Claudia , Goldstein David , Park Susanna B.
Published: February 2023

Background: Chemotherapy-induced peripheral neurotoxicity (CIPN) is a common complication of cancer treatment that produces functional disability. Increasingly, patient-reported outcome measures (PROMs) are used to assess CIPN, providing a broader symptom perspective than clinician-graded scales. Understanding when a reported change in CIPN symptoms meets the threshold for clinical significance is challenging. This study aimed to provide interpretation guidelines for validated CIPN PROMs, and thereby enable estimation of thresholds to identify clinically relevant symptoms. Methods: Patients commencing neurotoxic cancer treatments were assessed at 3 timepoints: baseline, midtreatment, and end-of-treatment. Trajectory of CIPN development was assessed by means of CIPN PROMs, EORTC Quality of Life – Chemotherapy-Induced Peripheral Neuropathy questionnaire (QLQ-CIPN20), and Functional Assessment of Cancer Therapy/Gynecologic Oncology Group – Neurotoxicity questionnaire (FACT/GOG-NTX). Thresholds were estimated for CIPN PROMs using the NCI CTCAE sensory neuropathy scale as the clinical anchor by midtreatment and end-of-treatment. Patients were assigned to a clinical change group according to CIPN development: either no development; grade 1 neuropathy (minimally important difference [MID]); or grade 2 neuropathy (clinically important difference). Distribution-based estimates (SD, 0.5) were also evaluated as supportive evidence. Results: In total, 406 patients were recruited to the study, of whom 62% (n=199/320) developed CIPN by midtreatment and 80% (n=274/343) by end-of-treatment. Anchor-based MID estimates by midtreatment were 5.06 (95% CI, 4.26–5.86) for the QLQ-CIPN20 and 3.54 (95% CI, 2.87–4.20) for the FACT/GOG-NTX. End-of-treatment MIDs were estimated to be 7.32 (95% CI, 6.23–8.40) for the QLQ-CIPN20 and 4.84 (95% CI, 3.98–5.70) for the FACT/GOG-NTX. Distribution-based MID estimations yielded lower values than anchor-based methods, at 3.73 for the QLQ-CIPN20 and 2.64 for the FACT/GOG-NTX at midtreatment and 5.52 for the QLQ-CIPN20 and 3.64 for the FACT/GOG-NTX at end-of-treatment. Conclusions: Findings from the present series aid meaningful interpretation for commonly used validated CIPN PROMs and provide thresholds that serve as guidance on how to interpret score changes, which will be useful for design and evaluation of clinical trials and clinical practice.
Effect of Yoga and Mediational Influence of Fatigue on Walking, Physical Activity, and Quality of Life Among Cancer Survivors
Authors: Lin Po-Ju , Altman Brian J. , Gilmore Nikesha J. , Loh Kah Poh , Dunne Richard F. , Bautista Javier , Fung Chunkit , Janelsins Michelle C. , Peppone Luke J. , Melnik Marianne K. , Gococo Kim O. , Messino Michael J. , Mustian Karen M.
Published: February 2023

Background: Cancer-related fatigue (CRF) negatively affects survivors’ walking, engagement in physical activity (PA), and quality of life (QoL). Yoga is an effective therapy for treating CRF; however, evidence from large clinical trials regarding how reducing CRF through yoga influences CRF’s interference with survivors’ walking, engagement in PA, and QoL is not available. We examined the effects of yoga and the mediational influence of CRF on CRF’s interference with walking, PA, and QoL among cancer survivors in a multicenter phase III randomized controlled trial. Patients and Methods: Cancer survivors (n=410) with insomnia 2 to 24 months posttreatment were randomized to a 4-week yoga intervention—Yoga for Cancer Survivors (YOCAS)—or standard care. A symptom inventory was used to assess how much CRF interfered with survivors’ walking, PA, and QoL. The Multidimensional Fatigue Symptom Inventory-Short Form was used to assess CRF. Two-tailed t tests and analyses of covariance were used to examine within-group and between-group differences. Path analysis was used to evaluate mediational relationships between CRF and changes in CRF’s interference with walking, PA, and QoL among survivors. Results: Compared with standard care controls, YOCAS participants reported significant improvements in CRF’s interference with walking, PA, and QoL at postintervention (all effect size = −0.33; all P≤.05). Improvements in CRF resulting from yoga accounted for significant proportions of the improvements in walking (44%), PA (53%), and QoL (45%; all P≤.05). Conclusions: A significant proportion (44%–53%) of the YOCAS effect on CRF’s interference with walking, PA, and QoL was due to improvements in CRF among cancer survivors. Yoga should be introduced and included as a treatment option for survivors experiencing fatigue. By reducing fatigue, survivors further improve their walking, engagement in PA, and QoL.