bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular expression of Forkhead Box C2 gene (FOXC2) and Prospero homeobox gene (PROX-1) in oral squamous carcinoma and their correlation with clinicopathological parameters: A prospective cohort study
Authors: Benitha Georgia , Ramani Pratibha , Jayakumar Selvaraj , Ramalingam Karthikeyan
Published: July 2024

Background:

Forkhead box C2 gene (FOXC2) acts as an epithelial–mesenchymal transition (EMT) inducer while Prospero homeobox 1 gene (PROX-1) function as a regulator of lymphangiogenesis and angiogenesis in oral squamous cell carcinoma (OSCC). It is presumed that PROX-1 has both tumour-suppressive and oncogenic effects. The main aim of this study is to evaluate the role of PROX-1 and FOXC2 in the invasion and progression of OSCC cases and to correlate their expression with various histopathological parameters.

Materials and Methods:

A prospective cohort study was conducted in a total sample size of 52 OSCC tissues and histologically tumour-free margins of 20. mRNA expression and protein levels of FOXC2 and PROX-1 were evaluated using real-time PCR and sandwich enzyme-linked immunosorbent assay techniques. Chi-square analysis and correlation analysis were done. Kaplan–Meier analysis evaluated the survival rate.

Results:

Mean Ct values of FOXC2 were 1.915 ± 0.519 and PROX-1 was 0.061 ± 0.173. There was a significant 2-fold increase in the FOXC2 expression and a 0.5-fold decrease in the PROX-1 expression in OSCC tissue. Increased levels of FOXC2 protein and decreased levels of PROX-1 with a mean difference of 1.64 ± 0.73 ng/ml and 1.27 ± 0.33 ng/ml were observed in OSCC compared to histologically tumour-free margins. A significant positive correlation was found between the FOXC2 expression and clinicopathological parameters such as staging, perineural invasion (PNI) and lymphovascular invasion (LVI) whereas PROX-1 showed a significant negative correlation with histopathological parameters such as staging, PNI, LVI and tumour staging. There was a significant positive correlation between the PROX-1 and histologically tumour-free margins in disease-free survival patients (P-value = 0.03).

Conclusion:

FOXC2 and PROX-1 expressions were correlated with lymphovascular invasion, OSCC tumour staging and PNI. Thus, FOXC2 and PROX-1 could be possible therapeutic targets in the treatment of OSCC that can inhibit the EMT in OSCC and thereby favouring a better prognosis.
Immunohistochemical analysis of p53 and p63 in selected odontogenic cysts and tumours
Authors: Bartake Anirudha R. , Sarode Sachin , Krishnapillai Rekha , Sarode Gargi , Narang Bindiya , Hallikeri Kaveri
Published: July 2024

Background:

It is a well-recognized fact that abnormal cell proliferation plays a crucial role in the development of odontogenic lesions. p53 is a tumour-suppressor gene which assists in cell cycle regulation and p63 is a homolog of p53 responsible for ectodermal differentiation and maintenance of stratified epithelial progenitor-cell. Analysing the tissue expression of p53 and p63 in odontogenic lesions may provide us with an insight into their potential role in the development of these lesions.

Objective:

The objective is to study the expression of p53 and p63 in selected odontogenic lesions using immunohistochemistry.

Materials and Methods:

Formalin-fixed paraffin-embedded tissues of 15 ameloblastomas, 10 adenomatoid odontogenic tumours (AOT), 15 odontogenic keratocysts (OKCs), 10 dentigerous cysts (DCs) along with 10 cases of normal mucosa were retrieved from the departmental archives. These specimens were then subjected to immunohistochemical staining using p53 and p63 oncoproteins.

Results:

p53 and p63 immune-expression showed mainly intranuclear localization. The mean positivity of p53 in ameloblastoma (59.45%) and OKC (26.38%) was significantly higher than AOT (6.77%) and DC (4%). In contrast, there was no significant difference in the positivity of p63 in between ameloblastoma (77.55%), AOT (69.50%), OKC (76.47%), and DC (50.69%).

Conclusion:

p53 expression can be correlated with the clinical behaviour of the odontogenic lesions and it can be used as a prognostic marker in odontogenic cysts and tumours. In contrast, p63 expression does not corelate with the biological behaviour of odontogenic lesions.
Deciphering the role of TLR3 polymorphisms in oral squamous cell carcinoma pathogenesis: A case-control study
Authors: Sharma Apoorva , Jaiswal Rohit , Singh Sarveshwarii , Asthana Prateek , Tandon Aanchal , Shakarwal Parul
Published: July 2024

Background:

Oral squamous cell carcinoma (OSCC) poses a significant global health burden, particularly prevalent in regions like India. Despite advancements in diagnostics, early detection of OSCC remains challenging, necessitating novel diagnostic modalities. Toll-like receptors (TLRs) and their polymorphisms have emerged as potential contributors to OSCC pathogenesis.

Methods:

This retrospective case-control study examined 120 individuals, including 60 OSCC cases and 60 healthy controls. Genotyping of TLR3 single-nucleotide polymorphisms (SNPs) rs3775290 and rs3775291 was conducted using TaqMan allelic discrimination real-time polymerase chain reaction. Functional consequence analysis and TLR3 expression profiling were performed to elucidate their role in OSCC pathogenesis.

Results:

Significant associations were observed between TLR3 SNPs and OSCC susceptibility, particularly at loci rs3775290 and rs3775291. Functional consequence analysis revealed pathogenic mutations in TLR3 genes, potentially affecting protein structure and function. TLR3 overexpression was detected in OSCC lesions, implicating its involvement in disease progression.

Conclusion:

TLR3 polymorphisms play a pivotal role in OSCC pathogenesis, offering potential biomarkers for diagnosis and prognosis. Targeting TLR3-mediated pathways may hold promise in personalised OSCC management. Further research is warranted to elucidate the precise mechanisms underlying TLR3-mediated carcinogenesis in OSCC, facilitating the development of tailored therapeutic strategies.
Analysis of total lip score system and total groove score for gender identification: A cross-sectional study
Authors: Alqarni Abdullah
Published: July 2024

Background:

Endless ink and pixel space have been spent to validate the use of cheiloscopy classification systems in the field of identification. It is becoming evident that lip-print patterns may provide indications about an individual’s gender, race, occupation, habits, blood type, and paternity. Over the course of time, much data have been collected on a substantial population in this field. In the present study, we strive to see how well a noble total lip scoring (TLS) system works in identifying a person’s gender among the College of Dentistry students. We also quantified the total groove score (TGS) and compared it with each quadrant for better authentication of the set study design.

Materials and Method:

A cross-sectional descriptive study was conducted among 60 dental students (30 males and 30 females), with an age range of 18–30 years. Lip prints were recorded using the writing pad method and subsequently digitalized by capturing the images using Adobe Photoshop CS 6 Extended Version, counted and summed up, quadrant-wise, in both upper and lower lips. The TLS and TGS between males and females were statistically calculated using the Jamovi project.

Results:

The mean value for TLS for males (n = 402; SD ± 92.1) is higher than that for females (n = 348; SD ± 86.1). The correlation matrix applying a non-parametric test for non-continuous data using Spearman’s ratio inferred a statistically significant correlation (-0.354) with a P-value of 0.005 for TLS, whereas a correlation (-0.162) of TGS with gender was not so significant with a P-value of 0.217.

Conclusion:

Our study proved the uniqueness of applying TLS as a novel approach to gender identification. The study revealed that males had a statistically higher lip score than females.

Clinical Significance/Future Implications:

Being unique, our study inferred the importance of TLS, which needs to be explored in detail for applying, evaluating, and validating its accuracy in forensic research that can help for errorless investigations as full-proof evidence in court.
Clinical management of bullous pemphigoid—The importance of cytology in diagnosis
Authors: Ramesh Preethi , Divyambika CV , Warrier Aravind S. , Joseph Leena Dennis
Published: July 2024

Bullous pemphigoid (BP) is a common immune-mediated blistering disorder with predominant skin involvement and occasionally oral manifestations. Vesiculobullous lesions of the oral mucosa present with similar clinical features, and hence arriving at a clinical diagnosis is aided by a valuable chairside investigation, exfoliative cytology. Cytology done in the present case ruled out pemphigus because of the absence of Tzanck cells in the smear. Biopsy and direct immunofluorescence further confirmed the diagnosis of BP. Treatment initiated with systemic steroids and immunomodulators, along with oral topical application of triamcinolone acetonide resulted in complete remission in 2 months. This case report highlights the role of cytology in the diagnosis of vesiculobullous lesions and management protocol for BP patients presenting with simultaneous skin and oral lesions.
Symptomatic Concomitant Pneumocephalus and Pneumorachis Following Spine Surgery: A Case Report and Review of Literature
Authors: Kanamarlapudi Gnana Shankar , Kumar Manoj , Bansal Tungish , Mittal Samarth
Published: July 2024

Lumbar spine decompression and fixation is one of the most common spine surgeries performed these days. Pneumocephalus and pneumorachis is pathological collection of air in cranial cavity and spinal canal respectively. An 82-year male underwent open lumbar decompression and fixation for lumbar spinal stenosis. There was no obvious intraoperative dural tear. In post-operative period patient complained of headache and dizziness. CT scan brain and whole spine and MRI brain obtained which showed the patient to have pneumocephalus and pneumorachis. The patient was managed conservatively with trendelenburg position, oxygen by mask. He improved symptomatically and follow up CT was suggestive of resolution of pneumocephalus. At 2 years follow-up the patient is doing well with no symptoms at present. We report a rare case of concomitant pneumocephalus with pneumorachis in a patient following lumbar decompression and fixation surgery and literature review.
Multitask Sentiment Analysis and Topic Classification Using BERT
Authors: Shah Parita , Patel Hiren , Swaminarayan Priya
Published: July 2024

In this study, a multitask model is proposed to perform simultaneous news category and sentiment classification of a diverse dataset comprising 3263 news records spanning across eight categories, including environment, health, education, tech, sports, business, lifestyle, and science. Leveraging the power of Bidirectional Encoder Representations from Transformers (BERT), the algorithm demonstrates remarkable results in both tasks. For topic classification, it achieves an accuracy of 98% along with balanced precision and recall, substantiating its proficiency in categorizing news articles. For sentiment analysis, the model maintains strong accuracy at 94%, distinguishing positive from negative sentiment effectively. This multitask approach showcases the model's versatility and its potential to comprehensively understand and classify news articles based on content and sentiment. This multitask model not only enhances classification accuracy but also improves the efficiency of handling extensive news datasets. Consequently, it empowers news agencies, content recommendation systems, and information retrieval services to offer more personalized and pertinent content to their users.
On a density conjecture about unit fractions (with an appendix by Thomas F. Bloom and Bhavik Mehta)
Authors: Bloom Thomas F.
Published: July 2024

We prove that any set

A\subset \mathbb{N}

of positive upper density contains a finite

S\subset A

such that

\sum_{n\in S}\frac{1}{n}=1

, answering a question of Erdős and Graham.
The use of task-based learning and teaching in ESP courses for tertiary students of kinesiology and dietetics
Authors: Jurša Potocco Barbara
Published: July 2024

This teaching report examines how the principles of task-based learning and teaching were applied to two university-level ESP courses, namely a course for second-cycle students of Dietetics and one for first-cycle students of Kinesiology. The paper briefly outlines the main language learning tasks used in these courses: for students of Dietetics, the tasks included a role play of a dietetic consultation with a focus on counselling skills and a clinical focus, a structured class debate on the universal applicability of plant-based diets, and a role-play of a job interview in the field. For students of Kinesiology, the tasks involved preparing a short physical activity break for the class, designing different sports and physical activities for different groups of clients, furnishing a fitness studio and pain assessment. The report also reflects on the teacher-perceived effectiveness of these tasks and the challenges accompanying their implementation.
Discipline, culture and community in writing: getting specific with EAP
Authors: Hyland Ken
Published: July 2024

It is almost a cliché now to say that writing (and reading) are not abstract skills but only make sense within wider social and cultural practices. This means that we must see the social context of an event as more than just the immediate environment surrounding it. We have to look beyond specific acts of writing to recognise how wider institutions and social groups influence them. We must, in other words, see communities as cultures. Culture is a key dimension of writing and of writing differences, and it can influence every aspect of language use. In this paper I will explore some of the ways that disciplinary cultures influence writing in academic contexts by looking at repeated patterns of language choices as evidence of specific cultural beliefs and practices. I discuss some data which supports the importance of specificity by drawing on some of my research over the last decade, arguing that identifying the particular language features, discourse practices, and communicative skills of target groups is central to teaching English in universities.
Il lessico architettonico nell’italiano delle origini
Authors: Đorović Danijela , Stanojević Slađana
Published: July 2024

Di tutte le terminologie artistiche quella dell’architettura fu prima a costituirsi come un sistema lessicale sovraregionale, sorta dai volgarizzamenti e dalle traduzioni vitruviane. Benché i primi testi architettonici in volgare risalgano alla fine del Quattrocento dando vita a un primo nucleo di termini architettonici di base, il Medioevo con le sue imponenti imprese edilizie non poté non disporre di una terminologia del settore. Questa prima fase dello sviluppo del lessico architettonico è caratterizzata dalla spiccata instabilità nonché dalla presenza di diverse varianti regionali, così come dall’apporto notevole dei vocaboli usati nei cantieri e nelle botteghe da capomastri, manovali e architetti e trasmessi, quasi esclusivamente per via orale. Il presente lavoro si pone l’obbiettivo di analizzare i termini architettonici più frequenti e la loro sorte nell’italiano delle origini, dal punto di vista morfologico, etimologico e semantico, partendo dal corpus del dizionario storico dell’italiano antico TLIO (Tesoro della lingua italiana delle origini) formato da testi documentari, scientifici e giuridici dai primi secoli del volgare fino al 1375.
Influence Of School Enviorment On The Learning Experience Of Stutterers In Inclusive Education In Owerri
Authors: James Eburikure Olayi , Uche Opara , J E Ewa , Jennifer C Egbuzieuzo
Published: July 2024

This study investigated influence of school environment on learners with stuttering in an inclusive school in Owerri, Imo State, Nigeria. Using a descriptive research design the study adopted simple random sampling technique to select 115 identified learners with stuttering from across. questionnaire on influence of environment on learners with stuttering from 10 schools with inclusive education program, (boys 62 and girls 53). The ten itemed questionnaire was administered to the respondents, data obtained from the respondents was analyzed using independent T-test and mean statistical tools at 0.05 level of significance. The study revealed that impact of stuttering influences negatively on learners with stuttering. With the result showing a composite mean value of 3.12 indicating a much higher outcome than the benchmark score of 2.50 expected of learners generally. Also, there was significant mean score difference in the learning experience of male and female learners who are stutterers as male students are much more affected by stuttering disorder than female learners in the studied schools. Therefore, it was recommended that students who are stutterers should endeavour to participate fully in classroom teaching and learning experience and practice their reading repeatedly so as to develop the capacity to master the pronunciations of words, sounds and syllables.
Social Networking And Students’ Academic Achievements In Mathematics In Senior Secondary Schools, Ikom Education Zone, Cross River State, Nigeria
Authors: John A Okri , Joseph O Joy , Etta I Idaka , Joseph B Ukpong , Njong T Catherine
Published: July 2024

This study examined social Networking and Students’ Academic achievement in Senior Secondary Schools in Ikom Education Zone, Cross River State, Nigeria. The Independence variables examine were: use of Facebook and YouTube while the dependent variable was students’ academic achievement in Mathematics. To achieve the purpose of the study, two research questions and two hypotheses were formulated to guide the study. Literature was reviewed based on the variables. The research design adopted was survey research design. One hundred and sixty-five (165) SS II students who offered Mathematics in public secondary schools were randomly selected for the study. The instruments used for data collection was a 20 – items questionnaire titled “Social Networking and Students’ Academic Achievement Questionnaire (SNASAAQ), and achievement test in Mathematics constructed by the researchers, Independent t-test was used as statistical tool for data analysis. Each of the hypotheses was tested at .05 level of significance. The findings of the study revealed that the use of Facebook and YouTube significantly influenced students’ academic achievement by SS II students in Mathematics. Based on the findings, it was recommended among other things that government/school proprietors should provide in-service training for Mathematics teachers to enhance achievement especially on use of social networking.
Humic substances in soils of diverse parent materials in humid tropical environment of south east nigeria.
Authors: M Afu S , M Olim D , O Nwamuo L , I Akpama A , E Aaron M
Published: July 2024

The knowledge of humic substances of soil is essential for soil fertility management and productivity. The study evaluated the humic substances (HS) and physicochemical properties of soils of different lithologies. Twenty composite soil samples were collected at the depths of 0-15 and 15-30 cm in both upland and inland of sandstone (SS), limestone (LS), mudstone (MS), basement complex (BC) and shale (SH) and analyzed for HS and physicochemical properties. HS were higher in surface than subsurface soils and in SH, SS and MS than other parent materials. Humic acid had mean values of 0.649 and 0.683 g/kg, 0.327 and 0.055 g/kg, 0.736 and 1.167 g/kg, 0.976 and 0.839 g/kg and 0.449 and 0.411 g/kg in surface soils of upland and inland in BC, MS, SS, SH and LS. In subsurface soils, average values of humic acid were 0.322 and 0.426 g/kg, 0.055 and 0.012 g/kg, 0.499 and 0.713 g/kg, 0.656 and 0.908 g/kg and 0.276 and 0.047 g/kg in the upland and inland of BC, MS, SS, SH and LS correspondingly. Fulvic acid had averages of 0.237 and 0.3125 g/kg, 0.533 and 0.751 g/kg, 0.297 and 0.707 mg/kg, 0.6524 and 0.568 g/kg and 0.220 and 0.007 g/kg in the surface soils of upland and inland of BC, MS, SS, SH and LS. In subsurface, fulvic acid had means of 0.244 and 0.363 g/kg, 0.227 and 0.328 g/kg, 0.056 and 0.128 g/kg, 0.040 and 0.402 g/kg and 0.001 and 0.415 g/kg in upland and inland of BC, MS, SS, SH and LS respectively. BC was higher in clay content than other parent materials. ECEC correlated significantly and positively with BS, Ca, Na, pH, silt, K and Mg while fulvic and humic acids correlated positively with TN and OM. pH was strongly acidic in soils of upland and varied from medium acid to slightly acid in inland. OC was high in inland and varied from high in MS, SH and SS to low in BC and LS in upland. Available P, TN, exchangeable bases, ECEC varied from low to high while BS was high in soils of both upland and inland.
Adherence to routinely prescribed medications among paediatric sickle cell disease patients in Kumasi, Ghana
Authors: A. Agyekum Merlene , B. Nguah Samuel , Attakorah Joseph , K. Nettey Gustav , G. Oppong Kwaku , Paintsil Vivian , O. Akoto Alex , O. Buabeng Kwame
Published: July 2024

Objective: To measure the adherence to routinely prescribed medications among Sickle Cell Disease (SCD) patients in Kumasi, GhanaDesign: A cohort study involving paediatric SCD patients presenting to the outpatient clinic at the Komfo Anokye Teaching Hospital (KATH).Setting: The Pediatric SCD Outpatient Clinic of KATH.Participants: Two hundred SCD patients visiting the outpatient clinicIntervention: NoneMain Outcome Measure: Cost and adherence to Penicillin V, Folic Acid, Hydroxyurea and Vitamins prescribed to SCD patients on routine outpatient visits.Results: Of the 200 participants, the highest and lowest phenotypes were Hb-SS (162, 80.1%) and Sβ-thal (3, 1.5%), respectively. The adherence rate to routine medications was 13.5% (95%CI: ut9.1% to 19.0%). Patient factors that affect adherence included forgetfulness 98(49%), cost 54(27%), and side effects 28(14%) of medication, and improvement in health 7(3.5%). Hydroxyurea was the costliest to the patients with a median (IQR) cost of GHc 75 (0, 450) or USD12 (0, 73), and the least was folic acid with a median of GHc 6 (0, 42) or USD 1 (0, 7). 44.5% of all medications prescribed were not obtained in full. 83% of those who did not purchase all the medicines attributed this to cost, with 13% indicating they had some at home.Conclusion: There is low adherence to routine medications used by SCD patients in Kumasi, and this could be because of their relatively high cost. Further studies should be made to assess the non-adherent effects of SCD medications on patients' health.
Is aqueous extract of soybeans neurotoxic? Preliminary evidence from histological evaluation of the cerebellum and cerebrum of Wistar rats.
Authors: Orheruata A.R. , Enogieru A.B.
Published: July 2024

BACKGROUND AND AIM: Reports indicate that there is a worldwide surge in plant-based eating patterns as typified by the increasing number of vegetarians and vegans. However, several medicinal and nutritional plants, seeds, and fruits can induce neurotoxicity. Accordingly, this study investigated the histological effects of aqueous Soybeans seed extract (ASSE) on the cerebellum and cerebrum of adult Wistar rats.
METHODOLOGY: Following purchase and acclimatization, twenty-four rats were randomly divided into four groups of six rats per group as follows: Group A (control) received 1 ml distilled water daily, group B received 250 mg/kg body weight of ASSE daily, group C received 500 mg/kg body weight of ASSE daily and group D received 1000 mg/kg body weight of ASSE daily. All administration, via an oral gavage, lasted for twenty-eight days. After sacrifice, the cerebellum and cerebrum were separated, weighed, and processed for histological assessment.
RESULTS: Results showed no significant difference (P>0.05) in the body, brain, cerebellar, relative cerebellar, cerebral, and relative cerebral weights of rats treated with all doses of ASSE compared to control. Also, no significant difference (P>0.05) was observed in the cerebellum-brain and cerebrum-brain ratios of treated rats in comparison to control. Histological findings revealed normal and intact histology of the cerebellum and cerebrum layers in treated rats when compared to control.
CONCLUSION: Taken together, these findings provide preliminary histological evidence demonstrating that ASSE was safe for the experimental rats and had no adverse effect on the cerebellum and cerebrum.
Media społecznościowe potrafią zabić - zjawisko wtórnej wiktymizacji po zbrodni 16. lipca 2023 r. w Poznaniu na przykładzie portalu Sadistic.pl
Authors: Sierocka Beata
Published: July 2024

The main thesis of the article – constructed from the standpoint of transcendental-pragmatic communicating philosophy – is to indicate aggression present in today’s media space as the most significant threat to discursive rationality. Elaborating on this thesis required, on the one hand, understanding how previous theories conceptualized aggression, and on the other hand, explaining the specificity of discursive rationality. On this basis, it was possible to propose a different approach to the problem of aggression, which, in subsequent steps, allowed the recognition that (1) due to communicative aggression present in the specific media space shaped by the latest media, the fundamental tendency toward consensus in communicative processes undergoes destruction precisely because of the specificity of this “megamedial” space. This (2) consequently prevents the maintenance of the discursive nature of human rationality, and thus (3) poses a fundamental threat to the existence of the communication community. In a “positive plan”, these diagnoses ultimately point to the principle of co-responsibility and the normative ethical framework based on it as determinants of social practices safeguarding the idea of consensus.
Employment With the Use of Artificial Intelligence: Opportunities and Risks
Authors: Bąba Michał
Published: July 2024

Human beings and artificial intelligence, although materially different, are never separate. Technology rests within man, in this resting it surpasses him. Technology draws the world and the human into itself and retains it. The opposites of man and artificial intelligence are in dispute. For an artificial intelligence system to be an artificial intelligence is to engage in a dispute between man and the essence of technology. What is the essence of technology? It lies in what the technology really is. It establishes this dispute in the form of an artificial intelligence system that makes it public. The human being, his or her rights, freedoms, duties, what appears to be inviolable, inalienable and unalienable in his or her being, what reaches him or her and is only given to him or her, without which he or she would not be a human being, is only experienced through the artificial intelligence system, being subjected to its influence. This article attempts to demonstrate that, in this dispute, technological development does not necessarily mean progress any more.
BUEN GOBIERNO Y GOBIERNO CORPORATIVO EN LA ADMINISTRACIÓN PÚBLICA Y SUS ENTIDADES INSTRUMENTALES
Authors: FAYA BARRIOS ANTONIO LUIS
Published: July 2024

Actas de las XVII Jornadas de Estudio del Gabinete Jurídico de la Junta de Andalucía. Sevilla, 19 y 20 de noviembre de 2015. Con estas Jornadas podemos determinar el conjunto de normas, principios, pautas, modelos y protocolos de actuación, que configuran la diligencia exigible al gestor público en el desarrollo de sus funciones.
The Effect of Profitability, Liquidity and Company Size on Capital Structure in Companies Listed on the Indonesian Stock Exchange
Authors: Wulandari Ica , Wulandari Ika
Published: July 2024

This study investigates the effect of profitability, liquidity, and firm size on the capital structure of firms listed on the Indonesia Stock Exchange (IDX). Using data from manufacturing firms, the study found that profitability and liquidity have a negative and significant influence on capital structure decisions, with more profitable firms tending to rely on less debt and more internal sources of funds. However, firm size does not consistently have a significant negative impact on capital structure, suggesting that external factors such as capital market conditions and economic policies have a more dominant role in determining a firm's capital structure. These results provide important insights for financial practitioners in designing appropriate funding strategies to maximise firm value and effectively manage financial risk in the Indonesian capital market.
The Effect of Transparency and Accountability of Village Fund Management on Community Welfare
Authors: Mani Christin Natalia , Nugraeni Nugraeni
Published: July 2024

The objectives of this study are as follows: 1) To find out how transparent management of village funds affects the welfare of the people of Umanen Lawalu Village, Central Malaka District. 2) To find out how the Accountability of Village Fund Management affects the welfare of the Community of Umanen Lawalu Village, Central Malaka District. The research method used in this research is a quantitative method. Research methods are scientific procedures, practices, or procedures for obtaining data for research purposes that have certain useful and usable objectives. Based on the results and conclusions of the research, it shows that accountability and transparency in processing funds in Umanen Lawalu village, Central Malaka have a positive effect. If accountability and transparency are able to provide a positive response and are able to account for the proper use of funds for the community.
Exploring Innovative Music Teaching Management Systems: A Systematic Literature Review
Authors: Arum Tania Ayu Sekar , Jacob Deden Witarsyah
Published: July 2024

This systematic literature review explores innovative music teaching management systems (MTMS) to understand current trends, technological advancements, and pedagogical approaches. The review synthesizes findings from various studies, focusing on how MTMS facilitate effective music education through digital tools, platforms, and methodologies. It highlights key innovations such as interactive software, online learning environments, and mobile applications that enhance both teaching and learning experiences. Additionally, the review examines the integration of artificial intelligence and machine learning in personalizing music education, providing adaptive feedback, and fostering student engagement. The pedagogical implications of these technologies are considered, emphasizing their role in supporting differentiated instruction and accommodating diverse learning styles. Furthermore, the review addresses the challenges and limitations associated with implementing MTMS, including issues of accessibility, teacher training, and the digital divide. The findings suggest that while MTMS offer significant potential for enriching music education, successful implementation requires a holistic approach that includes adequate infrastructure, professional development, and continuous evaluation. This review contributes to the field by providing a comprehensive overview of current MTMS innovations and their impact on music education, offering insights for educators, researchers, and policymakers aiming to enhance the quality and accessibility of music instruction through technology.
El rol de Atahualpa en la historia andina: un análisis de la memoria histórica y su representación en la educación digital
Authors: Ramirez Ivonne Celeste Carbo , Fiallos Jorge Luis Rodríguez , Salazar Crysthian Manuel Chávez , Jiménez Karina Marisol Moeses
Published: July 2024

El objetivo de este estudio es investigar las actitudes y preferencias de los usuarios hacia los recursos educativos digitales relacionadas con la historia andina y la figura de Atahualpa. Se busca comprender cómo los individuos perciben la calidad, la efectividad y la utilidad de estos recursos en su proceso de aprendizaje. A través de una encuesta diseñada específicamente, se pretende explorar la diversidad de opiniones y experiencias de los usuarios, desde una disposición positiva hacia el uso de recursos digitales hasta posibles preocupaciones o desafíos que puedan surgir en relación con su autenticidad, precisión histórica y capacidad para enriquecer la comprensión cultural. Además, se busca identificar los principales factores que influyen en la elección y la valoración de estos recursos, así como las oportunidades y desafíos asociados con su integración en la enseñanza y el aprendizaje de la historia andina y la figura de Atahualpa. Por último, se generan conocimientos y recomendaciones que puedan contribuir a mejorar la calidad y la efectividad de la educación histórica en entornos digitales, así como a informar el diseño y desarrollo de futuros recursos educativos digitales en este campo específico.
Sistematizacón de una experiencia pedagógica en una clase de matemáticas del sistema de educación superior ecuatoriano
Authors: Romero Nathaly Ragde Riofrio , Márquez Javier Oswaldo Yunga , Azan Jhon Paulino Camacho , Pindo Javier Martín Oyola , Rogel Elvis Mauricio Sánchez , Gadñay Alex German Gia , Macas Alexis Alonso González , Florin Johon Armando Luna
Published: July 2024

En este trabajo se comparó la metodología implementada en la enseñanza aprendizaje de la asignatura de Matemáticas II, con el método del ciclo del aprendizaje del constructivismo, se utilizó la sistematización de experiencias educativas para planificar, recolectar y reconstruir la experiencia vivida ,  para evidenciar cada una de las etapas del plan de sistematización se utilizó cámaras filmadoras, cámaras fotográficas, y encuestas, los datos de entrada que se obtuvieron en cada una de las etapas de la sistematización fueron analizados a través del método de la observación participativa, los resultados establecen que la forma que utiliza el docente para impartir su cátedra afecta la forma que tiene los estudiantes para aprender, siendo más adecuado el método del ciclo del aprendizaje ya que con él se logró obtener estudiantes más participativos y creadores de su propio conocimiento.
CAPÍTULO 6: INHIBIDORES DEL COTRANSPORTE SGLT-2
Authors: Inserra Felipe , Sanabria Hugo , Castaño Yanina , Castellaro Carlos , Márquez Diego , Dorado Enrique , Sivak Leonardo
Published: July 2024

Los inhibidores SGLT-2 han cambiado el horizonte del tratamiento de los pacientes con DM2 y también en aquellos que sin DM padecen enfermedad renal y/o ECV. Revisaremos la evidencia actual de estas drogas denominadas gliflozinas.
Durante los estudios realizados para evaluar, primariamente, seguridad CV en poblaciones con DM2, las complicaciones microvasculares, como la enfermedad renal que acompaña a la diabetes (ERD), se evaluaron como objetivos secundarios preespecificados.
En el estudio EMPA-REG OUTCOME, centralizado en pacientes con DM2 con ECV establecida se redujo un 39% el riesgo relativo (RR) en el objetivo preespecificado de nefropatía incidente o empeoramiento de la nefropatía, con resultados similares con ambas dosis de empagliflozina, 10 mg y 25 mg2. Un análisis post hoc de dicho estudio en pacientes sin ERC al inicio del tratamiento TFGe ≥60 ml/min/1,73 m2 o RAC ≤30 mg/g), el 47% mostró un RR para incidencia de ERD de 0,67 (0,47-0,94) y del compuesto renal (duplicación de creatinina basal, inicio de diálisis o trasplante o muerte renal) de 0,31 (0,16-0,63).
Comparative Study of Diabetic Retinopathy Detection Using Machine Learning Methods
Authors: Bhagyashree Madan  , Dr. Vijay Bhandari
Published: July 2024

Untreated diabetic retinopathy, a consequence of poorly managed chronic diabetes, can lead to complete vision loss. Early diagnosis and treatment are crucial to prevent severe complications. Currently, ophthalmologists dedicate significant time to manually diagnose diabetic retinopathy, causing discomfort to patients. Automated technologies offer a promising solution by swiftly identifying diabetic retinopathy and facilitating timely treatment to mitigate further ocular damage. This study proposes leveraging machine learning to extract and classify key features such as exudates, hemorrhages, and microaneurysms using a hybrid classifier combining support vector machines, k-nearest neighbors, and random forests.
Pengaruh Service Excellence dan E-Marketing terhadap Keputusan Pembelian Persewaan Alat Pesta Barokah Jaya di Sidoarjo
Authors: Hanafi M. Iqsan
Published: July 2024

Several factors, such as service quality and e-marketing, can influence purchasing decisions. This study examines the purchasing decisions of Barokah Jaya Sidoarjo. This study uses a descriptive quantitative approach. This study involved 99 customers of Barokah Jaya Sidoarjo from June to December 2023. However, the sample used consisted of 99 people who answered. The saturated sample method was used for sampling. Data collection was conducted through Google Form surveys featuring a range of statements rated on a Likert scale. The gathered data underwent several tests, including validity, reliability, normality, multicollinearity, heteroscedasticity tests, multiple linear regression analysis, and t-tests for individual significance. The findings indicate that service excellence has a significant influence on purchasing decisions for Barokah Jaya Sidoarjo and e-maketing has a significant influence on purchasing decisions.
Kewenangan Komisi Pemberantasan Korupsi dalam Fungsi Preventif Melalui Pendidikan Anti Korupsi
Authors: Angkat Ilham Syahputra , Koto Ismail
Published: July 2024

Indonesia is a state of law and has a variety of legal mechanisms for resolving various existing issues. Although it is not easy as a rule of law to prevent the occurrence of criminal acts of corruption, committed by certain people for their own benefit and as a means of enriching themselves, these acts are severely detrimental to the state and even the interests of the masses. As a developing country, corruption cases in Indonesia continue to occur, causing losses and hampering economic growth and development as well as the development of the country's infrastructure. All natural resources in Indonesia are utilized as well as possible for the prosperity of the Indonesian people as a manifestation of the practice of noble values in the nation and state. Therefore, eradicating corruption needs to be carried out to prevent the recurrence of criminal acts of corruption. In Indonesia, the Corruption Eradication Commission exists as a state instrument with the duty and authority to take action to prevent, eradicate, and handle the occurrence of criminal acts of corruption. One of the tasks of the Corruption Eradication Commission itself is to carry out a preventive function, namely carrying out preventive actions to avoid the occurrence of criminal acts of corruption in Indonesia. Therefore, one way for the Corruption Eradication Committee to take preventive action is to carry out anti-corruption education programs in society, especially for young people at school and at universities in Indonesia. With this, it is hoped that the Corruption Eradication Commission can make a real contribution to efforts to prevent acts of corruption in Indonesia.
Risiko Terjadinya Tindak Pidana Pencucian Uang Melalui Pasar Modal
Authors: Rahma Talitha , Elvaretta Elvia , Rato Dominikus , Setyawan Fendi
Published: July 2024

Capital markets, namely activities related to the offering and trading of company assets. In transactions in the capital market, several features of financial transactions are carried out quickly, adaptively and cross-border, allowing the capital market to be used as a means and medium for laundering money from illegal funds. The capital market can be said to be a unique financial sector compared to other financial services sectors. This is because the capital market can be used to launder illegal funds obtained from a criminal act which are then used to generate legitimate profits through fraudulent activities.
Fenomena Stigma Maskulinity terhadap Fanboy Kpop di Kota Medan
Authors: Fadhilatil Rizka , Zahra Sylva , Sazali Hasan
Published: July 2024

Changes in the meaning of men which are symbolized by k-pop boy bands foster a new ideology of maleness or masculinity. This ideology opens up a new social space for placing adolescents with their male identity built on aspects constructed by k-pop boy bands. This identity then becomes an interesting discourse to examine, with the question of how the meaning of masculinity is constructed, consumed and deconstructed by K-Pop fans. The researcher uses a qualitative approach with the aim of uncovering the data described by data sources and participants to find out about how the technological aspects of the library cooperation network and digital library information in the city of Medan, to obtain quality results from the research conducted. The results of this study resulted in the phenomenon of K-Pop boygroup fanboy masculinity which can create a stigma of masculinity that is given and even labeled for men who like K-Pop or become fanboys of K-Pop boygroups. There are already many non-K-Pop people or men who are literate and aware of the meaning of male masculinity, which does not have to be defined by having a well-built body, tanned and black skin, having a firm face and jawline that reflects a strong male figure. ..
Pengaruh Konten Sosial Media TikTok Terhadap Pemahaman Brand Knowledge VOffice Indonesia
Authors: Barelvi Faqih , Menati Fajar Rizki  , Mentari Anugrah Imsa
Published: July 2024

Brand knowledge plays a very important role in supporting a company's digital marketing efforts by building a positive image, increasing awareness, expanding online presence, building relationships with influential parties, managing crises, and increasing user engagement. vOffice is a virtual office space service provider in various locations in Indonesia. vOffice provides business solutions that include virtual office space rental, physical office space rental, and various other business support services, such as the availability of shared office services, there are various types of products to support the continuity of business activities such as office services, Event Space, Meeting Rooms, Legality Management services to virtual offices. This study aims to obtain information about the effect of tiktok social media content on understanding the brand knowledge of the Voffice Indonesia virtual office through tiktok social media. In this study, the theory used is the S-O-R theory (Stimulus- Organism-Response). S-O-R theory explains the process of how a stimulus produces a response. The most basic interaction occurs when individuals perform actions and receive responses from others The research method used is a quantitative approach with a survey method. This method comes from positivism, which emphasizes empirical experience instead of assumptions or logic. Based on his research objectives to be achieved, he found that the understanding of vOffice brand knowledge through TikTok social media has an influence of 86.6%. It can be concluded that the results of this study show that H0 is rejected and there is an effect of using the TikTok application has great potential as a marketing tool, especially in increasing purchase interest, brand awareness, and brand knowledge of consumers.
Pengaruh Media Sosial Terhadap Perilaku Konsumen : Studi Kasus Instagram dan Pembelian Produk Fashion
Authors: Nursapia Harahap  , Hafiz Mansyur  , Nadya Dwi Ananda  , Dwi Arlintang  , Elisa Damayanti  , Susan     Ramadhani  , Nisrina Ardra Hafizha  , Afrini Yuninda Silitonga  , Rangga Diva
Published: July 2024

This study aims to examine the influence of social media usage, particularly Instagram, on consumer behavior in the context of fashion product purchases. The method used in this research is a quantitative approach, with data collected through questionnaires distributed to respondents. The results show that Instagram usage has a significant impact on the frequency of fashion product purchases. The t-test reveals that each additional hour of Instagram use per day significantly increases the frequency of fashion purchases. These findings indicate the importance of Instagram as an effective marketing platform in the fashion industry.
Students’ Perceptions Of Tiktok As An Alternative Media To Enhance Speaking Skills
Authors: Olivia Farisca Adhani  , Silih Warni
Published: July 2024

In language learning, the ability to communicate orally plays a vital role, enabling individuals to interact and understand others in different social situations. Oral communication in language learning is crucial due to its relevance in daily interactions and academic endeavors. The research aims to investigate EFL students' perceptions on using TikTok as a learning tool, particularly its impact on speaking abilities. The study explores the effectiveness of TikTok in enhancing speaking proficiency. Through a descriptive qualitative methodology, the study examines the perspectives of EFL students at a school in Jakarta, Indonesia, regarding the use of TikTok for language learning. Purposive sampling was employed to select participants who utilize TikTok for their English language learning. Data collection involved observation and interviews to gain insights into students' experiences and perceptions.  Findings reveal diverse viewpoints among students regarding the utility of TikTok for English language learning, encompassing both positive and negative opinions. While TikTok offers opportunities for exposure to authentic language and engagement with native speakers, challenges such as accuracy and fluency are noted. Despite these challenges, TikTok is recognized as a potential platform for improving speaking skills due to its accessibility and engaging content. This research provides valuable insights into the perceptions of EFL students regarding TikTok's role in language learning. By addressing the research question of students' perceptions of TikTok's effectiveness in English language teaching, the study contributes to understanding the potential of social media platforms like TikTok as supplementary tools for language learning.
Analisis Penerapan Metode Akumulasi Biaya Sebagai Alat untuk Menentukan Harga Pokok Produksi pada Usaha Upiya Karanji Gorontalo
Authors: Monoarfa Valentina , Natalia Natalia , Wayan Dini Ari Ni
Published: July 2024

Determining the cost of production is an important thing to pay attention to because of the increasing competition between companies in producing quality products competitively in the Upiya Karanji Gorontalo Business. The aim of this research is to determine the application of the cost accumulation method as a tool for determining the cost of production using the full costing method. The research methads used to collect data are interviews, observation and documentation. The results of determining the cost of production using the full costing method are greater than the calculation of the company's cost of production, this occurs because the company does not calculate all factory overhead costs in detail, therefore it is recommended that Upiya Karanji's business calculate all overhead costs in detail and use the calculation method full costing.
Analisis Efisiensi Biaya Tenaga Kerja Langsung pada PT. Davincy Airindo
Authors: Monoarfa Valentina , Putri Taufik Lina , Putri Husain Kartika
Published: July 2024

This study was conducted with the aim to determine the efficiency of direct labor costs carried out by the company PT Davincy Airindo. In this study using literature review and observation, namely by conducting research in the field through direct interviews and data collection, related documents from the company through internet media. The data obtained is analyzed using the quantitative descriptive analysis method, namely how to compare labor costs that actually occur (actual). The results of the analysis will show whether direct labor costs are used efficiently to produce a product. This shows that Direct Labor Cost Control is in the efficient and stable category (in control).