bluuebunny/crossref_metadata_2025 huggingface dataset:
Hover Handling Qualities of Fixed-Pitch, Variable-RPM Quadcopters of Increasing Size
Authors: Walter Ariel , McKay Michael , Niemiec Robert , Gandhi Farhan , Ivler Christina
Published: June 2022

Fixed-pitch, variable-RPM quadcopters of increasing size are simulated in hover. Three aircraft sizes are considered, with rotor diameters of 4, 6, and 8 ft(1.2, 1.8, and 2.4 m) and gross weights of 300, 680, and 1200 lb (136, 308, and 544 kg) respectively. Control design is performed
for each aircraft using CONDUITR, first using standard ADS-33E-PRF handling qualities specifications. Froude scaling is then applied to the specifications in order to design more comparable, aggressive controllers for the two smaller aircraft. Piloted commands and gust inputs are
simulated in the time domain in order to estimate the necessary motor current margins needed for adequate maneuverability local to hover. Of the maneuvers considered, a yaw rate step requires the highest current margin for the smallest aircraft, while the longitudinal velocity step requires
the highest current margin for the others, regardless of the Froude scaling of the handling qualities metrics. Using the maximum current values from these simulations, the motor weight fraction is 8.3–10.6% for the 300-lb vehicle, 11.6–13.0% for the 680-lb vehicle, and 15.8% for
the 1200 lb. Motor weight requirements can be reduced on the larger two aircraft by flying with the pitch and roll axes exclusively in the attitude command, attitude hold mode, rather than translational rate command. In this case, step commands in yaw rate are limiting for the 680-lb vehicle
(10.7–11.8% motor weight fraction) and heave commands are limiting for the 1200-lb vehicle (13.6% motor weight fraction). Estimated motor weight requirements are also reduced by decreasing the rotor inertia and introducing additional filtering into the aircraft commands.
Severe hyponatremia due to water intoxication in a child with sickle cell disease: A case report
Authors: Rossi Roberta , Castagno Emanuele , Matarazzo Patrizia , Tuli Gerdi , Saracco Paola , Urbino Antonio F. , Bondone Claudia
Published: June 2022

Water intoxication is a potentially fatal hypo-osmolar syndrome with brain function impairment. Isolated symptomatic excessive ingestion of free water is very rare in childhood. We report a case of acute hyponatremia due to water intoxication without Antidiuretic Hormone (ADH) excess in a child with sickle cell disease. The boy was admitted to our Emergency Department because of new-onset prolonged generalized seizures. Blood test showed hyponatremia, and elevated creatine kinase value; neuroimaging was negative. His recent medical history revealed that on the day before he had drunk about 4 liters of water in 2 hours to prevent sickling, because of back pain. He was treated with mild i.v. hydration with normal saline solution and showed progressive clinical improvement and normalization of laboratory test. Rhabdomyolysis is a rare complication of hyponatremia whose underlying mechanism is still unclear.
‘Kufa kwa jongololo nkhusiya mphete’: A critique of gender injustice procreation cultural practices of the Sena of Malawi
Authors: Chibambo Lucy T.
Published: June 2022

The central argument of this article is that kufa kwa jongololo nkhusiya mphete, a concept that is used to encourage procreation amongst the Sena people of Nsanje District in Malawi, is a dehumanising concept for the barren men and women, in the context of HIV and AIDS and gender justice, where men and women need concepts that affirm life in all its fullness. The study uses feminist cultural hermeneutics as a tool to analyse dehumanising cultural practices, through the examination of three Sena cultural practices.Contribution: The study also questions the methodology used to engage indigenous knowledge, a methodology that denies traditional communities the right to maintain secrecy on some treasured indigenous practices. At the same time, the article argues that no protection should be afforded to indigenous practices that dehumanise the lives of people on the margins of power.
Lichenoid dermatitis treated with Ayurveda therapies
Authors: Javed Danish , Anwar Sana , Gupta Divya
Published: June 2022

Lichenoid dermatitis is a type of chronic eczema. Eczema can be correlated with Vicharchika (~wet eczema) described in Ayurveda. In acute conditions, this disease responds well to treatment, but in chronic presentations, it is difficult to manage due to its recurrent nature. Panchakarma (~five biopurification therapies) is well-known measure to improve the quality of life and prevention of recurrence in chronic diseases. In this case report, a 27-year-old male patient presented with chronic lichenoid dermatitis having symptoms of Kandu (~itching), Daha (~burning sensation), Ruja (~pain), Pidaka (~papules/eruptions), Srava (~discharge), Vaivarnya (~discoloration), and Rukshata (~dryness) treated with Ayurvedic interventions. Virechana (~therapeutic purgation) along with Ayurvedic oral medicines and wholesome dietary regimen were given for 12 weeks. Encouraging relief in various symptoms was observed after treatment. Rasayana (~rejuvenation) was also given to patient for prevention of recurrence. The patient has shown well tolerance and satisfactory adherence to treatment. No adverse event was reported during the course of therapy. After three months of treatment, disease progression was fully stopped and lesions resolved completely.
Bibliometric Mapping of Trends, Applications and Challenges of Artificial Intelligence in Smart Cities
Authors: Harnal Shilpi , Sharma Gaurav , Malik Swati , Kaur Gagandeep , Khurana Savita , Kaur Prabhjot , Simaiya Sarita , Bagga Deepak
Published: June 2022

INTRODUCTION: The continued growth of urbanization presents new challenges. This, in turn, will lead to pressure for sustainable environment initiatives, with demands for more and better infrastructure in the diminishing space available and improved quality of life for city dwellers at a more affordable cost. Smart Cities are part of the solution to the growing challenges of urbanization. The adoption of new technologies like artificial intelligence (AI) is transforming cities, making them smarter, faster, and predicting opportunities for improvement.
OBJECTIVES: This study is conducting a detailed bibliometric survey to investigate the applications and trends of Artificial Intelligence research for different areas of smart cities and emphasizing the potential effects and challenges of AI adaptation in smart cities over the past 30.5 years.
METHODS: For this study, the Scopus database was used to collect a total of 1925 documents published between 1991-2021 (July). The bibliometric analysis includes document types, subject categorization, document growth, as well as top contributing sources, countries, authors, and funding sponsors. It also analyses keywords, abstracts, titles, and characteristics of most cited documents.
RESULTS: The analyzed findings of this research study reflect not only the significance of AI technology for various applications within numerous sectors in the smart city but also major obstacles in AI research for various sectors of smart cities.
CONCLUSION: The research demonstrates that AI has the ability to construct today’s and tomorrow’s smart cities, but that each region’s potentials, conditions, and circumstances must be addressed in order to achieve a smooth internet city development.
Mapping what we know
Authors: Rabia Öztürk Sare
Published: June 2022

This article offers an outline of the literary translation flow from Turkish to Arabic between 1923 and 2005 based on a catalogue of translated literary works that were published in this period that was compiled for the purposes of this research. The aim of the article is to understand what kinds of works make it into a literary-linguistic domain when the host system has a turbulent history with the source system (in the case of Turkey and the Arab Middle East, a series of ideological and political factors were behind such turmoil). Based on Even-Zohar’s concept of clusters, the bibliographic data are consulted to trace the systemic infrastructure that helped determine which works from the source literature were admitted into the host literature. The process is carried out through identifying sets of relatable elements (translations, agents) that clustered around six thematic elements to form the repertoire of translated Turkish literature in the Arabic literary system. The analysis shows that the translation flow from Turkish to Arabic continued despite the historical rancour between Turkey and the Arab Middle East.
Anaesthesia related complications – a single centre data analysis at a tertiary hospital in central Switzerland
Authors: Gehrer Franziska , Hansen Damon , Konrad Christoph J.
Published: June 2022

AIMS: Anaesthesia safety has improved over time with severe anaesthesia-related complications and death becoming rare events. We investigated anaesthesia-related complications over a period of 17 years in this single centre retrospective observational cohort study. The main aims were to assess the temporal trends of anaesthesia-related complications, their distribution among clinics and their relation to emergency versus non-emergency interventions.

METHODS: In this retrospective, observational cohort study, anaesthesia and event protocols of patients who suffered from an anaesthesia-related complication were collected in the period from 1 January 2003 to 31 December 2019. These data sets were anonymised and grouped into demographic information, ASA physical status, information about dental status and hospital department. Out of the total of 257 cases that were reported to the department of anaesthesia at the Luzerner Kantonsspital, 110 were excluded as they were not anaesthesia-related and 14 because of incomplete reporting forms. The different complications were categorised by the severity injury scale score. The total number of anaesthetics during the study period amounted to 399,583.
RESULTS: 133 patients with complications were included. Six patients died owing to a partially anaesthesia-related complication, two suffered from permanent damage, 62 had temporary symptoms and in 63 patients dental damage occurred. The temporal trend showed a major decrease in severe anaesthesia complications and deaths, whiledental injuries were the main complications after 2010. Most of the complications were reported in the orthopaedic department, whereas dental injuries were predominantly reported in the otorhinolaryngology department. The majority of complications occurred during elective surgery although this was not significant (p = 0.53).
CONCLUSIONS: Severe anaesthesia-related complications and death decreased dramatically during the study period. Anaesthesia complications are not more frequent in emergency surgeries. Overall, complications occurred more frequently in orthopaedics, and dental injuries predominated in otorhinolaryngology.
Mediating role of corporate reputation in the relationship between corporate social responsibility and repurchase intention: A case study of McDonald’s fast food restaurant chain
Authors: Ha Nguyen Minh , Phong Le Quoc , Thang Tran Kiem Viet , Tam Huynh Luong , Dang Tran Hai , Hoa Nguyen Thi Mai
Published: June 2022

This study builds on a strong theoretical background to investigate the relationship between Corporate Social Responsibility (CSR) and consumer repurchase intention through a corporate reputation for McDonald’s distribution channel in Viet Nam. The study was carried out using two methods, qualitative and quantitative research. Qualitative research was conducted using deep interviews with twelve respondents. After being added from qualitative research, the official scale with twenty-one observed variables is used in quantitative research. A quantitative research approach with 279 valid samples was conducted to test the scale and theoretical model. Collected data were analyzed by using SPSS and AMOS software. The results demonstrated a positive impact of CSR on corporate reputation and repurchase intention. This study adds to the existing literature on the role of CSR in marketing by finding that a good corporate reputation along with relevant and integrated CSR activities has a much stronger impact on the repurchase intention of consumers. Findings from research have shown that inappropriate CSR practices can negatively impact the behavior of certain consumers. In the short term, McDonald’s CSR activities may convince consumers to repurchase, but it may not be very convincing and there is no guarantee that this repurchasing behavior will last, as only continuous CSR activities contribute to sustainable behaviour. Therefore, the theoretical contribution of this study is to introduce corporate reputation as a long-term benefit to the relationship between CSR and consumer repurchase intention.
Pembatalan Perkawinan Anak Perempuan di Bawah Usia Minimal Karena Unsur Paksaan Oleh Orangtua Pada Masa Pandemi Covid-19
Authors: Evelyn Santoso  , Setiawan Yuzak Eliezer
Published: June 2022

Perkawinan yang dilakukan oleh anak-anak dibawah umur (atau bisa disebut perkawinan dini) yang dipaksakan oleh orang tua kepada anaknya mengalami kenaikan Indonesia karena beberapa faktor. Faktor-faktor yang menyebabkan meningkatnya perkawinan anak di tengah pandemi antara lain karena masalah ekonomi mengingat para orang tua mereka banyak yang diberhentikan dari pekerjaannya atau usaha mengalami penurunan pendapatan secara drastis. Keadaan ekonomi yang sulit membuat beberapa orangtua beranggapan bahwa dengan mengawinkan anak mereka dapat meringankan beban keluarga. Berdasarkan latar belakang tersebut, maka rumusan masalah yang dibahas adalah Bagaimana akibat hukum terhadap perkawinan dibawah usia minimal yang dilandasi unsur paksaan oleh orangtua. Tujuan penelitian untuk menganalisa akibat hukum terhadap perkawinan dibawah umur yang dipaksakan oleh orangtua khususnya karena tekanan ekonomi akibat COVID-19. Kegunaan penelitian diharapkan dapat memberikan penjelasan mengenai akibat perkawinan yang memuat unsur paksaan, alasan-alasan pembatalan perkawinan, pihak yang dapat membatalkan, serta terpenting adalah akibat perkawinan dibawah umur bagi anak secara fisik maupun psikis. Metode penelitian menggunakan metode yuridis-normatif. Hasil penelitian, bahwa berdasarkan Pasal 7 ayat (1) Undang-Undang Nomor 16 Tahun 2019 tentang Perubahan atas Undang- Undang Nomor 1 Tahun 1974 tentang Perkawinan (“UU 16/2019”) mengatur bahwa perkawinan hanya diizinkan jika pihak laki-laki dan perempuan sudah mencapai umur 19 tahun. Serta Berdasarkan Pasal 6 ayat (1) Undang-Undang Nomor 1 Tahun 1974 tentang Perkawinan menyatakan bahwa: “Perkawinan harus didasarkan atas persetujuan kedua calon mempelai.” Perkawinan dibawah umur dipaksakan dapat dibatalkan mengingat anak akan mengalami beberapa permasalahan mental dan kesehatan seperti masalah kehamilan, penyakit menular, dan kematian pada bayi maupun ibu. Kesimpulan Perkawinan dibawah usia minimal yang dilandasi unsur paksaan oleh orangtua dapat dibatalkan oleh pihak-pihak yang ditentukan berdasarkan Pasal 23 UU Perkawinan atau (bagi yang beragama Islam) berdasarkan Pasal 73 Kompilasi Hukum Islam.
La investigación científica. Una aventura epistémica, creativa e intelectual
Authors: Avellaneda Callirgos Lolo , Morante Gamarra Percy Carlos , Dávila Cisneros Juan Diego
Published: June 2022

Es una realidad que la investigación científica se ha convertido en un desafío intelectual, tanto para las instituciones formativas como para los profesionales en ejercicios, es una realidad demostrada que las carreras profesionales deben asumir como eje transversal el estudio de la investigación científica como parte consustancial de la formación. El propósito se reconoce en la necesidad de brindar un referente teórico metodológico para el desarrollo de la investigación educativa. La sistematización teórica realizada permitió el abordaje de los temas y el entendimiento del proceso investigativo de manera holística, lógica y transformadora. O sea, comprender que la Metodología de la Investigación Científica es una, con sus especificidades según las áreas del conocimiento; sus resultados transformadores y aportadores al enriquecimiento de la práctica histórico social concreta depende de la lógica investigativa con que se desarrolle el proceso investigativo, de la flexibilidad, compromiso y de los análisis valorativos que se realicen, desde posiciones éticas y de compromiso social y humano. Justamente, el resultado científico debe estar en función de la creación de bienes materiales o espirituales, debe ser compartido con la comunidad de investigadores, y no, para un grupo determinado de intereses, que muchas veces se sienten más atacados que favorecidos, se deben entender como valor de un momento histórico social concreto, desde concepciones integracionistas y transformadoras, con enfoques inclusivos, de equidad e interacción social brinde soluciones sostenibles con el propósito de resolver los problemas socioeconómicas, políticas, culturales y ecológicas.
THE EFFECT OF DRIVER SAFETY PRIORITY ON SLEEPY DRIVING BEHAVIOR: LINEAR AND NON-LINEAR REGRESSION ANALYSIS
Authors: KARA Karahan , İPEKÇİ Emre
Published: June 2022

Driver safety priority is among the factors that affect the sleepy driving behavior of truck drivers. The aim of this paper is to determine the effect of truck drivers' driver safety priority on sleepy driving behavior with linear and non-linear models. Two hypotheses have been developed within the scope of the research. The sample area consists of 399 Turkish truck drivers. Surveys were collected face to face and online between January 2022 and April 2022. The sample area has been determined by simple random method. "Driver safety priority" and "Sleepy driving behavior" scales is used, which is tested for reliability and validity. Simple regression analysis has been performed for the linear model. In the selection of non-linear models, curve estimation models have been tested. The “Power” estimation model has been determined as the best model. According to the research findings, driver safety priority has a negative and significant effect on sleepy driving behavior in both linear and non-linear models. In addition, it has been determined that there is no significant difference between the percentages of explanation of linear and non-linear models. It has also been determined that the coefficient of the driver safety priority of the linear model on sleepy driving behavior is higher than the non-linear model. Based on the empirical findings, implications for both managers and drivers have been presented.
RESULTS OF THE FIRST STAGE OF THE STRATEGY FOR THE SOCIO-ECONOMIC DEVELOPMENT OF THE CHUVASH REPUBLIC UNTIL 2035
Authors: Zotikov Nikolay Z.
Published: June 2022

The Chuvash Republic is one of the 14 regions that make up the Volga Federal District. The Republic has great innovative potential and unrealized competitive advantages. In assessing the total investment potential of the constituent entities of the Russian Federation, the leaders are 5 regions of the district with high rates of socio-economic development (the Republics of Tatarstan and Bashkortostan, Perm Territory, Nizhny Novgorod and Samara regions). Taking leading positions in certain industries (electrotechnical cluster, potato and milk production, etc.), in terms of a number of indicators of social and economic development, the republic is ranked 13–14th in the Volga Federal District and 50–60th in Russia. With this in mind, by decision of the Government of the Russian Federation, the Chuvash Republic was included into the list of 10 regions of the country with a low level of socio-economic development. The strategy is to be implemented within a five-year period, the implementation of the strategy is divided into three stages: the first stage – 2020-2021, the second – 2022-2025, the third – 2026–2035. The purpose of the study is to analyze the implementation of the first stage of the Strategy for the socio-economic development of the Chuvash Republic until 2035, and to assess the impact of the results of the first stage on achieving the goals set in the Strategy-2035. The relevance of the study is caused by the fact that the socio-economic situation of the whole country depends on the results of the socio-economic development of the regions. The study found that the average annual growth rate of indicators (production volume, gross regional product, budget revenues, and quality of life indicators), estimated based on the duration of the Strategy, were not met at the 1st stage. Indicators characterizing the state of development of small and medium-sized enterprises (the number of small enterprises, the number of people employed in them, their share in budget revenues) are deteriorating.
APPROACHES TO THE ASSESSMENT OF THE COMPANY MARKET VALUE
Authors: Ivanitskaya Iraida P.
Published: June 2022

The relevance of the research topic is due to the fact that most modern appraisers use Western methods and valuation standards when assessing the market value of a business. All this leads to some difficulties at various stages of the assessment, and subsequently leads to errors and inaccuracies in the resulting assessment. Modern assessment experience in Russia shows that the methods that are currently used do not always take into account, or do not fully take into account industry specifics. Due to the lack of evidence-based guidelines, appraisers themselves determine the need to take into account certain features of the company. Despite the fact that the methodological apparatus of valuation is being constantly improved, the problems of estimating the market value of an enterprise, as well as the company's shares, are not sufficiently covered in the economic literature. The purpose of the article is to study the modern practice of forming the market value of Russian enterprises. The scientific novelty lies in the systematization of methods for estimating the value of companies that can be applied in the valuation. The practical significance of the study lies in the fact that the main provisions and conclusions can be applied in the educational process when delivering lecture courses. Russian enterprises can use the results of the study to develop their investment policy, and to assess the effectiveness of investments in the stock market, government agencies can use them to regulate the securities market.
THE LEGAL NATURE OF ELECTRONIC EVIDENCE IN CIVIL PROCEEDINGS IN THE CONTEXT OF DIGITALIZATION
Authors: Aleksandrova Nadezhda V. , Ivanov Nikolay V.
Published: June 2022

The relevance of the article is due to the fact that in civil proceedings, electronic evidence can be considered the most popular method of obtaining evidence to date. However, in law enforcement practice, there are many gaps in the formation of the institution of electronic evidence. The advantage of electronic evidence in civil proceedings is quite obvious, which makes it necessary to take a different look at this type of evidence. The courts, certainly, strive to respect the interests of the parties when considering cases on the basis of competition and equality of the parties, but the study of judicial practice shows that the presence of electronic evidence stands out against the other evidence and acquires a special status that requires research, detailed legislative development and procedural regulation. At the same time, it should be noted that there has been insufficient research on this topic in the scientific and procedural doctrine; in this connection, the opinions of researchers and their assessment are given. The purpose of the article is to determine the legal nature of electronic evidence in civil proceedings, especially in the context of the development of digitalization and electronic information technologies. The procedural legal, formal legal, logical, dialectical and other methods of scientific research make up the methodological basis. Based on the results of the study, it was concluded that the legal nature of electronic evidence is closely related to modern technical means, and the position on the need to consolidate procedural measures, the use of information and communication tools to provide civil proceedings in the modern judicial system is also justified.
NEW DIGITAL RIGHTS AND THEIR TYPES: PROBLEMS OF LEGAL QUALIFICATION IN CIVIL LAW
Authors: Khuzhin Alfir M. , Aleksandrova Nadezhda V.
Published: June 2022

The article reveals the features of the legal regulation of digital rights, their regulatory and legal consolidation in civil legislation, the peculiarities of their application in civil and property turnover, and the existence of a close connection of this category of rights with information technologies and resources. Attention is focused on the norm-definition of the concept of "digital rights". The opinions of scientists and researchers on the importance of the problem of digital rights and its legal qualification and consolidation at the legal level are given. Certain types of digital rights that have found consolidation in industry legislation are considered. The purpose of the study is to analyze the category and legal content of digital rights and their types: problems of legal qualification within the framework of the current civil legislation. According to the results of the study, the authors believe that digital rights should be recognized as new objects of civil rights. It is necessary to expand the legal novel on the definition of digital rights and consolidate it in law, taking into account the practical civil turnover, which will make it possible to bring digital rights to a higher legal level and defining new types, criteria and objects of digital rights.
Comorbid Diabetes and Depression among Older Adults – Prevalence, Correlates, Disability and Healthcare Utilisation
Authors: Abdin Edimansyah , Vaingankar Janhavi A , Picco Louisa , Seow Esmond , Chua Boon Yiang , Ng Li Ling , Mahendran Rathi , Chua Hong Choon , Heng Derrick MK , Chong Siow Ann
Published: June 2022

Introduction: The objectives of this current study were to: 1) examine the prevalence and correlates of diabetes mellitus (DM) among older adults (aged 60 years and above) in a multi-ethnic population; 2) examine the prevalence and correlates of comorbid DM and depression among them; and 3) assess the effect of comorbid depression on disability, cognition and healthcare utilisation. Materials and Methods: Data for the current study came from the Well-being of the Singapore Elderly (WiSE) study; a single phase, cross-sectional survey conducted among Singapore residents aged 60 years and above. A total of 2565 respondents completed the survey; depression was assessed using the Automated Geriatric Examination for Computer Assisted Taxonomy (AGECAT) while a diagnosis of DM was considered if respondents stated that a doctor had diagnosed them with DM. Results: DM was reported by 25.5% of the population. The prevalence of depression was significantly higher in those diagnosed with DM than those without DM (6% vs 3%). After adjusting for sociodemographic correlates, smoking and other chronic conditions, DM remained significantly associated with depression and subsyndromal depression. However, after including measures of functioning and cognitive impairment as covariates, DM was not significantly related to depression and subsyndromal depression. Those with comorbid DM and depression were more likely to be of Indian and Malay ethnicity, aged 75 to 84 years (versus 60 to 74 years) and widowed. Conclusion: Given the significant association of certain sociodemographic groups with comorbid depression among those with DM, targeted interventions for prevention and early diagnosis in these groups should be considered. Key words: Direct medical care costs, Singapore, Well-being of the Singapore elderly
Estudos bioquímicos do efeito leishmanicida de inibidores de enzimas modificadoras de histonas em Leishmania braziliensis in vitro e in vivo em modelo murino
Authors:   , Souza Luciana Ângelo de
Published: June 2022

As leishmanioses são doenças tropicais negligenciadas causadas por espécies patogênicas do gênero Leishmania. Leishmania braziliensis é a principal espécie causadora de leishmaniose tegumentar americana (LTA) no Novo Mundo. O tratamento das leishmanioses é limitado, causa efeitos colaterais graves e os parasitos têm desenvolvido resistência. Histonas Deacetilases (HDACs), Proteínas Argininas Metiltransferase (PRMTs) e Amino-oxidases Dependentes de FAD (LSD1) são enzimas envolvidas no controle da estrutura da cromatina e são possíveis alvos para novos medicamentos contra as leishmanioses. Neste trabalho foram testados 86 inibidores dessas enzimas contra amastigotas intracelulares de L. braziliensis na infecção in vitro e três inibidores foram testados em modelo de infecção animal. Os resultados mostram que oito inibidores de PRMTs e LSD1 apresentaram baixa toxicidade para macrófagos e efeito leishmanicida superior a 50% nos ensaios de infecção. BSF2 foi o inibidor selecionado com o melhor potencial leishmanicida. Para os inibidores de HDAC (HDACi), cinco mostraram efeito leishmanicida significativo, com EC 50 entre 4,38 - 10,21 μM e índice de seletividade de 6 a 21,7. Resultados de citometria de fluxo corroboram com análises de microscopia eletrônica de transmissão indicando que os HDACi levam a alterações no ciclo celular e indução de apoptose em L. braziliensis. A produção de óxido nítrico pelos macrófagos infectados não foi alterada após o tratamento com os cinco principais HDACi. Na experimentação animal, os compostos TH60 (5 mg/kg) e o TH74 (10 mg/kg) diminuíram a lesão na pata dos camundongos infectados, sendo o efeito maior e igual ao do medicamento Glucantime®, respectivamente. A diminuição da lesão corroborou com a ausência de parasitos nas lesões e com o aumento de TNF e INF-γ. As análises bioquímicas e histopatológicas mostraram menor toxicidade dos HDACi em relação ao Glucantime®. Esses resultados demonstram que inibidores de HDAC, PRMTs e LSD1 podem ser promissores para o tratamento da LTA. Palavras-chave: Epigenética. HDACs. Inibidores de HDACs. Leishmania braziliensis
Relação entre Investimento em Intangíveis e Desempenho Econômico-Financeiro
Authors: Panucci Filho Laurindo , Hein Nelson , Kroenke Adriana
Published: June 2022

O objetivo desta pesquisa consiste em analisar a relação entre investimentos em intangíveis e desempenho econômico-financeiro. Com base no objetivo classifica-se como uma pesquisa descritiva, documental e quantitativa. A amostra foi composta de 4480 empresas de 35 países do G20 analisando-se um período de sete anos. Utilizou-se o indicador sintético DP2 para avaliar as empresas por meio de 25 indicadores econômico-financeiros e 3 indicadores de intangibilidade representados, portanto, por um único índice de intangíveis e outro de desempenho econômico-financeiro para posterior aplicação de modelos de regressão linear. Analisou-se três modelos, a saber: um testando a relação entre intangíveis e desempenho econômico-financeiro, outro testando a mesma relação diferenciando os países e o terceiro diferenciando por setor de atuação. Os resultados apontam para uma relação positiva entre investimentos em intangíveis e desempenho econômico-financeiro e essa relação se mantém ao analisar os países, embora tenha algumas alterações para alguns países. Quanto aos setores de atuação essa relação se mantém. Conclui-se, portanto, que a relação é positiva e significativa quando se trata de investimentos em intangíveis e desempenho econômico-financeiro em empresas do G20 e que para EUA essa relação foi negativa, o que pode ser justificado pela composição de suas empresas. Os setores que mais representativos são aqueles que necessitam de inovação em produtos e serviços destacando-se com novas tecnologias. Espera-se contribuir com gestores para que possam avaliar a importância dos investimentos em intangíveis em diferentes contextos e como estes podem contribuir com a melhoria do desempenho da empresa.
As ações do Programa de Erradicação do Trabalho Infantil (PETI) em uma cidade da fronteira amazônica no período de 2014 a 2020.
Authors: Olavo Antônio Vagner Almeida , Pineda Carmen Nebot , Silveira Suely de Fátima Ramos , Mota Marinete Lourenço , Chagas Francisca Carla Ferreira das
Published: June 2022

Este artigo tem como objetivo verificar as ações realizadas pelo Programa de Erradicação do Trabalho Infantil (PETI) no Benjamin Constant – Amazonas. Como procedimento metodológico foi utilizado uma abordagem qualitativa com análise de documentos e a realização de entrevistas com os coordenadores do programa. Como resultado é apresentado 111 ações distribuídas nos eixos informação e mobilização, identificação, proteção social, defesa e responsabilização e monitoramento. Foi identificado ainda que as visitas dos ACS são uma estratégia utilizada para a identificação. Assim como a formação de parcerias nos eixos de identificação e proteção social. Contudo, algumas limitações foram evidenciadas como o quantitativo de servidores públicos que atuam no programa, registros de casos e a falta de parcerias internacionais. Conclui-se que o PETI no município de Benjamin Constant possui ações que atendem os eixos do programa. Contudo para que as ações tenham um maior alcance é necessário superar algumas limitações como o quantitativo de servidores, torna-se estratégico e por fim buscar parcerias internacionais.
Primary defect of ileal mesentery presenting as internal herniation and strangulation of the small bowel: Case Report
Authors: Marya Saleem  , Haris Janjua  , Muhammad Zeeshan Sarwar  , Syed Asghar Naqi
Published: June 2022

Primary internal hernia is a rare entity of acute intestinal obstruction. Delay in diagnosis and surgical intervention can cause ischaemia or gangrene of the small bowel and result in high morbidity and mortality. A 14-year-old boy presented to the emergency department with acute intestinal obstruction. On exploration, 3-4cm mesenteric defect was noted in the ileal region. Strangulated loops of the small bowel had gone through the mesenteric defect in a complicated way. Primary anastomosis was done after resection of the gangrenous small bowel.
Key words: Primary internal hernia, Acute intestinal obstruction.
A gender-based study of symptoms and risk factors associated with mortality in COVID-19 patients in a tertiary care hospital, Lahore
Authors: Bukhari Syeda Filzah , Saad Butt  , Muhammad Nadeem Yousaf
Published: June 2022

Objective: To determine the symptoms and risk factors associated with gender-specific mortality among coronavirus disease-2019 patients.
Method: The retrospective, descriptive, cross-sectional study was conducted at the coronavirus disease-2019 ward of the Jinnah Hospital, Lahore, Pakistan, and comprised record of confirmed cases of coronavirus disease-2019 diagnosed on the basis of characteristic clinical symptoms, radiological findings and polymerase chain reaction positivity from May 1 to August 31, 2020. Clinical symptoms, comorbidities and outcomes were extracted from the medical records. Data was analysed using SPSS 23.
Results: Of 337 cases, 132(39.2%) died. Among the deceased, 84(64%) were males with median age 61.5 (interquartile range: 22) and 48(36%) were females with median age 54.5 (interquartile range: 25).There were more female non-survivors who suffered from kidney disease 10(66.7%) than male non-survivors 5(33.3%) (p<0.05). Ischemic heart disease was more common among males than females (p=1.62).
Conclusion: The mortality rate in males was higher compared to females. The symptoms and risk factors associated with mortality varied between the genders.
Key Words: Mortality, Gender, Risk factors.
Health and Immune Boosting Techniques of General Adult Pakistani Population- A KAP Study
Authors: Khan Iman , Farooqi Shaheer , Vahidy Ahmed Safi , Qamar Mohammad Aadil , Dhillon Rubaid Azhar , Azam Ahmed
Published: June 2022

Objective: To discover Pakistani adult population’s perception about their general health, immune status and knowledge regarding immunity, and to highlight their efforts to improve it.
Method: The knowledge-attitude-practice study was conducted from January to May 2021, after approval ethics review committee of the Islamic International Medical College, Rawalpindi, Pakistan, and comprised individuals of either gender from the community aged 18 years or more and not suffering from any physical disability or mental illness. Data was collected using a pre-tested, self-administered questionnaire that was disseminated through online platforms. The collected data was analysed using SPSS 25.
Results: All the 455(100%) individuals approached responded to the questionnaire. The mean age of the subjects was the mean age was 22.6±7.579 years. There were 256(56.3%) female respondents, 283(62.2%) were aged 20-21 years, and 359(78.9%) hailed for the Sindh province. Most participants perceived their general health as ‘good’ 197(43.3%). The immune system function was reported ‘good’ by 200(44%), and the perception of general knowledge of immunity was reported ‘good’ by 189(41.5%) subjects. Inverse relationships were identified between stress levels and self-perceived health, and between receiving effective homeopathic treatment and ‘very good’ self-perceived immune status (p<0.05). People willing to take non-obligatory vaccines had a positive opinion about their self-perceived knowledge on immunity that produced a direct relationship (p<0.05).
Conclusion: The findings provide a framework of practices that should be promoted to improve health status of adult population in Pakistan.
Key Words: Health status, Immunity, Attitude to health, Healthy lifestyle, Knowledge, Practices.
Application of Soft Skills Among Prospective TVET Teachers to Face the Industrial Revolution 4.0
Authors: Mohd Fadel Nur Syazhirah , Mohd Ishar Mohamad Izzuan , Jabor Mohd Khata , Mohd Ahyan Nurul Aini , Janius Naldo
Published: June 2022

The development of Malaysia's social and economic capital depends on the younger generation as a result of the country's education system. Education is also the trigger for creativity and the generator of innovation that equips the younger generation with the skills needed to compete in the job market and enable overall economic development. In this regard, in the national education system, teachers play a role as human builders to produce a younger generation in meeting the needs of the ethical industry revolution 4.0 (IR 4.0). Thus, a quantitative study was conducted on final year students who took TVET education programs at IPTAs in Malaysia to review the readiness and knowledge of the soft skills of future TVET teachers to meet the challenges of the Industrial Revolution 4.0. A set of questionnaires containing 62 items including demographics of respondents using 5 Likert scales was constructed using the Google Form application and distributed to a total of 175 respondents. The findings of the study were analyzed using Statistical Package for Social Sciences (SPSS) Version 20 software to identify the mean, standard deviation, and Pearson’s correlation coefficient. Overall, it was found that the level of readiness and acceptance of students towards IR 4.0 is still at a moderate level and there is a significant relationship between the level of students' knowledge of soft skills with the readiness of prospective TVET teachers to face the challenges of the Industrial Revolution 4.0.
The Effect of Nurses Stressogenic Factors and Psychoemotic State on Care Cooperation
Authors: Šleinytė Ieva , Mikaliūkštienė Aldona
Published: June 2022

Nurses inevitably experience stress in their work, which affects their psycho-emotional state. Complicated business and interpersonal relationships, conflicts with colleagues, patients and their relatives, high workload, difficulty in decision-making, nursing of dying patients, working in pandemic conditions cause stress, anxiety, fear, sleep disturbances, exhaustion and depression, which affect the psycho-emotional state of nurses and cooperation between them.

Cooperation between nurses is important not only for the quality of work of the nurses themselves, but also for the staff of other health care institutions and for the well-being of patients.

The aim of the research - to analyze the scientific literature on the nurses stress experience at work, their emotional state and their impact on mutual cooperation. Research methods: systematic search of articles in PubMed, Cochrane ClinicalKey, BMJ Best Practice, ScienceDirect and Google Scholar databases. The results showed that stress and psychoemotional status of nurses are related and affect their cooperation. As a result of constant stress, most nurses experience both physical and psychological health problems, which affect teamwork.
Polygamy is an Affront to Romantic Relationship: A Critical Analysis in Mariama Ba'S So Long a Letter and Ama Ata Aidoo’s Changes.
Authors: Apio Lydia
Published: June 2022

Studies show that majority of African men engage in polygamous marriages, where the men marry more than one wife. Mariama Ba's So Long a Letter and Ama Ata Aidoo's Changes are two texts that portray polygamy as an affront to romantic love. The present study seeks to highlight the various constructions of polygamy in the texts and to showcase how polygamy deprives women of romantic love and critique its effects on the lives of characters in the texts. This study, therefore, is worth examining to shed a light of the social ills of polygamy in the society today. The study is a qualitative one, it employs textual and critical analysis to analyse the texts. The analysis indicates that polygamous marriages do not guarantee healthy relationship between spouses, men use polygamy to subject women to inferior positions, women in polygamous marriages are depressed, lonely and are also deprived of joy and love and there is also disintegration between the children in polygamous homes. The study adopts polygamy as the main theoretical framework in theorizing the work. Findings of the study have implications for scholars and society to reorient their minds about polygamous marriages.
EFFECTS OF SYNONYMS IN ENGLISH AS SECOND LANGUAGE IN KENYA; A CRITICAL LITERATURE REVIEW
Authors: Obata Albert
Published: June 2022

Purpose: Synonym is a paradigmatic relation that enables lexically simple units to have same meaning as lexically complex units and vice versa. It is necessary to develop student’s vocabulary by use of synonyms. By learning the synonym, the students not only know one word but also other words that have nearly same meaning on the text. The purpose of the study therefore is to evaluate the effects of synonyms in English as second language in Kenya.

Methodology: The paper used a desk study review methodology where relevant empirical literature was reviewed to identify main themes and to extract knowledge gaps.

Conclusion: Learning vocabulary is one of the most efficient ways in improving the English students’ comprehension. The study concluded that it is necessary to develop students’ vocabulary by use of synonyms. By learning the synonym, the students not only know one word but also other words that have nearly same meaning on the text.

Recommendations: The study concluded that teachers can use synonym in learning vocabulary with their own strategy or other subject to enrich students’ knowledge of English vocabulary. Also, students can use synonym in learning certain subject when the aim of their learning is comprehended. Further there is need for the government to procure and distribute enough teaching and learning materials that can facilitate the improvement of learning English vocabulary.
Conservative management and minimal intervention in patients with natal and neonatal teeth: Report of four cases
Authors: Pardo Hernández Carolina , Guerrero Torres Claudia Isabel , González Bejarano Laila Yaned
Published: June 2022

Natal and neonatal teeth are present at birth or in the first month of life. They are observed more frequently in the mandibular central incisors, and in most cases, these teeth represent the true primary teeth. Clinical characteristics, possible complications and the clinical course are parameters to consider for proper management. Nevertheless, different reports argue that complications may occur after extraction in newborns. To date, there are no documented cases reported in the literature describing complications in retained teeth, such as aspiration of a tooth. The objective of the present study is to introduce four cases, three of which were treated with conservative management. Considering that the prevalence has increased progressively in recent years, neonatologists and pediatric dentists must make an early diagnosis and offer adequate treatment, providing general and oral wellness for each patient. The success of the treatment depends on periodic follow-up.
ABAY’S PHILOSOPHY AND THE CULTURAL CODE OF THE KAZAKHS
Authors:   Institute of Philosophy, Political Science and Religious Studies of the RK MES CS, Barlybaeva G. , Shaidulina D. ,   Institute of Philosophy, Political Science and Religious Studies of the RK MES CS, Nussipova G. ,   Institute of Philosophy, Political Science and Religious Studies of the RK MES CS
Published: June 2022

The article discusses the philosophical heritage of Abay, in whose ethical teaching Kazakh philosophy reaches its most mature stage. It is noted that the thinker was able to embody in his creations the thoughts and aspirations of the Kazakhs, their concepts of being, morality and ethics. All the work of the Kazakh philosopher is full of deep reflections on a whole, universal, harmonious and moral person, and his main goal was to teach what to do and what not to do in order to become a Person, to acquaint people with the true essence of good and evil. Abay is one of those philosophers and poets who form a person’s soul, the soul of the Kazakh people, and therefore, their national identity,the formation of which proceeded in the conditions of nomadic lifestyle accompanied by interactions with other cultures. He tries to reveal a unique character of the Kazakhs’ world, i.e. their cultural code. Abay's philosophical views, permeated with the ideas of moral improvement, kindness, mercy, justice, and tolerance, perform as the basis of the Kazakh national worldview, which forms the Kazakhs’ cultural code.
Knowledge and Association of Solar Pump Users Regarding Vegetable Production Technology in Jaipur Rajasthan
Authors: k Pramod , Gupta Shobhana , Sharma K. C. , Badhala B. S. , Sharma R. N.
Published: June 2022

Rajasthan has outstanding solar radiation in India and a solar water pump is a great investment that makes money in the long run. The present study was conducted in Jaipur district with 120 beneficiary and non- beneficiary farmers regarding knowledge about the improved practices of vegetable production possessed by solar pump users during 2020. The practices namely- selection of improved seed variety, time of sowing, seed treatment, organic and chemical manure application of irrigation at the right time, intercultural operations, weed management, insect and disease management etc. were found as popular practices. The results of the study revealed that majority (95%) of beneficiary fall into the category of medium to high level of knowledge against 80 per cent of the non-beneficiary were falling under low to medium knowledge level. It can be summarized that the variables viz., education, occupation, annual family income, size of land holding, farm mechanization, utilization of information, contact with extension agents etc. were found significant with their knowledge of vegetable production technology. The results also depicted that age was found in non-significant relationship with knowledge of vegetable production technology. There was a significant association between knowledge of vegetable production technology of non-beneficiaries with their occupation, size of land holding and contact with extension agents. In case of age no association was found between age and knowledge of vegetable production technology for both the beneficiary and non-beneficiary farmers.