bluuebunny/crossref_metadata_2025 huggingface dataset:
Students Perceptions of Learning Biology at SMA Negeri 1 Binjai
Authors: Zahra Maurin , Ulfa Syarifah Widya , Jayanti Ummi Nur Afinni Dwi
Published: October 2023

This study aims to identify students' perceptions of learning biology at SMA Negeri 1 Binjai Kab. Langkat. This research is directed at learning that takes place at the school and classes X-IPA, XI-IPA and XII-IPA as research samples. This study uses a survey method. Sampling is by means of probability random sampling in the form of proportionate stratified random sampling. because the study population was divided into several strata or sub-groups and separate samples were taken from each sub-group. The number of respondents obtained is 123 students. The instrument used is a questionnaire that has been prepared in such a way and has been validated previously. The results of the analysis show that students' perceptions of biology learning on average show negative results. So the student's perception of learning biology at SMA Negeri 1 Binjai Kab. Langkat is in the unfavorable category. Some of the things that influence students' perceptions of learning biology at SMA Negeri 1 Binjai Kab. Langkat are internal and external factors. Internal factors include students' learning abilities, motivation towards biology lessons and the ability to develop a knowledge. While external factors include the strategies used, learning media and physical conditions that support learning when it is in progress.
Analisis Penggunaan Dialek Tengger Pada Masyarakat Desa Ngadirejo Kecamatan Tutur dan Desa Mororejo Kecamatan Tosari (Kajian Dialektologi)
Authors: Dwi Windi Agustia , Widayati Wahyu , Tobing Victor Maroli Tua , Utami Sri , Haerussaleh Haerussaleh
Published: October 2023

Penelitian ini membahas tentang penggunaan dialek suku tengger pada Masyarakat Desa Ngadirejo Kecamatan Tutur dan Desa Mororejo Kecamatan Tosari (Kajian Dialektologi). Tujuan dari penelitian ini yaitu Mendeskripsikan Perbedaan fonologis variasi dialek bahasa Suku Tengger di Desa Ngadirejo Kecamatan Tutur dan Desa Mororejo Kecamatan Tosari dan Menganalisis penggunaan kosakata pada masyarakat Desa Ngadirejo Kecamatan Tutur dan Desa Mororejo Kecamatan Tosari. Sumber data yang diambil dalam penelitian ini yaitu percakapan atau tuturan dalam keseharian masyarakat Desa Ngadirejo dan Desa Mororejo. Metode yang digunakan dalam penelitian ini yaitu metode simak dan metode simak libat bebas cakap. Metode analisis data yang digunakan adalah metode padan. Kesimpulan dalam penelitian ini Terdapat Dialek Suku Tengger pada Masyarakat Desa Ngadirejo dan Desa Mororejo yaitu perbedaan fonologi berupa Vokal, Konsosnan, Diftong dan Kluster dan Terdapat Penggunaan Kosakata pada Dialek Suku Tengger berupa Kosakata Dasar, Kosakata Aktif dan Pasif, Kosakata Umum dan Khusus dan Kata Benda.

Kata kunci: Dialek, Suku Tengger, Kajian Dialektologi
Analisi Analisis Bahan Ajar Bahasa Indonesia Ditinjau dari Kurikulum Merdeka
Authors: Pertami Ovinita Wikantari , Numertayasa I Wayan
Published: October 2023

Penelitian ini merupakan penelitian kualitatif deskriptif. Subjek penelitian dilakukan di SMA Negeri 1 Rendang yang bertujuan untuk menganalisis bahan ajar Bahasa Indonesia yang ditinjau dari kurikulum merdeka. Metode pengumpulan data yang digunakan adalah dengan wawancara, kuisioner, dan obsevasi. Pengambilan data dilakukan di kelas XA dan XB di SMA Negeri 1 Rendang. Penelitian ini bertujuan untuk mengetahui apakah dengan adanya perubahan kurikulum bahan ajar yang digunakan sudah sesuai dengan kurikulum merdeka. Bahan ajar yang menjadi Fokus penelitian adalah buku paket Bahasa Indonesia, LKS Bahasa Indonesia dan hal terkait bahan ajar yang menggunakan kurikulum merdeka. Hasil yang diperoleh dari penelitian ini menunjukkan bahwa seiring perubahan kurikulum bahan ajar juga mengikuti peruhannya, dari bahan ajar berupa buku paket dan LKS yang sudah ada di sekolah sudah memakai kurikulum merdeka, sebagai sekolah penggerak.
Pengembangan Media Flash Card dalam Penguatan Pembelajaran Keterampilan Menulis Teks Deskriptif Siswa SMP
Authors: Irawan Riyan Wik , Nugrahani Farida , Sudiyana Benedictus
Published: October 2023

Penelitian ini betujuan untuk mengembangkan media pembelajaran flashcard dan mengetahui kelayakanya serta mengetahui peningkatan keterampilan menulis teks deskriptif siswa. Penelitian ini menerapkan metode penelitian pengembangan atau R&D (Reseach and Development) dengan menggunakan    rancangan pengembangan Borg & Gall melalui enam langkah dengan produk flashcard yang dilengkapi dengan barcode. Sebagai subjek penelitian adalah seorang ahli materi, seorang ahli media, dan seorang guru bahasa Indonesia SMP. Pegumpulan data melaliu kuesioner kelayakan media, observasi, wawancara, dan dokumentasi. Analisis data menggunakan statistik deskriptif kuantitatif. Hasil penelitian menunjukan bahwa (1) media pembelajaran menulis teks deskripsi dapat  dikembangkan melaui media flashcard; (2) media pembelajaran flashcard sangat layak karena mendapatkan penilaian kelayakan 92,7% dari ahli materi, ahli media, dan guru; (3) media pembelajaran flashcard meningkatan keterampilan menulis teks deskriptif siswa Siswa sekolah menengah pertama terbukti dengan naiknya rata-rata nilai siswa sebesar 9.Siswa dapat mengambil manfaat dari penggunaan media flashcard yang diproduksi sebagai alat pembelajaran. Penelitian ini menyarankan agar para guru yang ingin mengedukasi siswanya tentang cara membuat teks deskriptif yang efektif dapat melakukannya.
Pengembangan Bahan Ajar Teks Sastra Bahasa Indonesia Madrasah Ibtidaiyah Berbasis Moderasi Beragama
Authors: Rosita Farida Yufarlina , Puspidalia Yuentie Sova , Afifah Neny Nur
Published: October 2023

Penelitian ini bertujuan menghasilkan bahan ajar teks sastra bahasa Indonesia berbasis moderasi beragama dan melihat efektivitas penggunaan bahan ajar. Penelitian ini menggunakan jenis penelitian pengembangan (R&D) dengan model 4-D. Uji validasi dilakukan oleh empat ahli, masing-masing dua ahli dari segi materi dan dua ahli dari segi media. Beberapa aspek yang menjadi penilaian ahli materi yaitu dari segi isi materi, bahasa, dan penyajian. Sementara itu, ahli media menilai aspek tampilan bahan ajar dan karakteristik bahan ajar. Uji efektivitas bahan ajar juga dilakukan pada siswa kelas I MI Maarif Panjeng, Ponorogo. Hasil uji t menunjukkan bahwa t hitung (8,492) > t tabel (2,01808). Hal itu menunjukkan bahwa bahan ajar yang dikembangkan efektif digunakan oleh siswa kelas I MI Maarif Panjeng, Ponorogo.
Peningkatan Keterampilan Menulis Teks Deskripsi Menggunakan Metode Bermain Peran (Role Playing) pada Peserta Didik Kelas VII A SMP Negeri 5 Sangatta Utara Tahun Pelajaran 2023/2024
Authors: Wakhid Sahari Nor
Published: October 2023

Penelitian ini dilaksanakan berdasarkan kondisi kemampuan menulis teks deskripsi peserta didik di kelas VII SMP Negeri 5 Sangatta Utara yang masih rendah. Tujuan dilaksanakannya penelitian ini untuk mendeskripsikan peningkatan keterampilan menulis teks deskripsi menggunakan metode bermain peran (role playing) pada peserta didik kelas VIIA SMP Negeri 5 Sangatta Utara tahun pelajaran 2023/2024. Penelitian Tindakan Kelas ini menggunakan pendekatan bersifat deskriptif kualitatif dan pengumpulan data, sedangkan teknik yang dipakai adalah tes dan observasi. Subjek penelitian yakni peserta didik kelas VII A SMP Negeri 5 Sangatta Utara berjumlah 32. Hasil analisis data yang didapat setelah melaksanakan penelitian dengan menggunakan metode beramin peran (role playing) adalah terjadinya peningkatan keterampilan menulis teks deskripsi peserta didik. Hal ini terlihat rata-rata keterampilan menulis teks deskripsi peserta didik dari data yang telah diperoleh pada siklus 1 yakni 75 dan meningkat pada siklus 2 yakni 85. Berbanding lurus dengan data juga menunjukkan peserta didik yang memenuhi dan melampaui Kriteria Ketercapaian Tujuan Pembelajaran (KKTP) berdasarkan interval nilai yang telah ditetapkan terjadi peningkatan pada setiap siklus, yakni pada siklus 1 62,5% dan pada siklus 2 87,5%.
Pengaruh Model Contextual Teaching and Learning Terhadap Kemampuan Menulis Teks Deskripsi Di Kelas VII SMP HKBP Sidorame Medan Tahun Ajaran 2023/2024
Authors: Silalahi Nia Rusadi , Sitohang Tigor , Siagian Beslina Afriani
Published: October 2023

Populasi dalam penelitian ini adalah seluruh siswa kelas VII SMP HKBP Sidorame Medan Tahun Ajaran 2023/2024 berjumlah 30 siswa. Penelitian ini menggunakan pendekatan eksperimen dengan desain One-Grup Pretest-Posttest Design .Untuk memperoleh data digunakan penugasan menulis teks deskripsi di kelas VII SMP HKBP Sidorame Medan sebelum model Contextual Teaching and Learning diperoleh skor terendah 35 dan skor tertinggi 85 dengan rata-rata 59,66 dan sesudah menggunakan model Contextual Teaching and Learning diperoleh skor terendah 45 dan skor tertinggi 95 dengan rata-rata 72,33. Berdasarkan hasil perhitungan yang dilakukan diperoleh Thitung = 4,127 dan Ttabel = 2,045 dengan taraf signifikan 5% = 2,045 menuju Thitung > Ttabel. maka hipotesis alternatif (Ha) diterima. Berdasarkan hasil penelitian maka dapat disimpulkan bahwa model Contextual Teaching and Learning berpengaruh terhadap kemampuan menulis teks deskripsi kelas VII SMP HKBP Sidorame Medan.
Ocular surface disease in atopic dermatitis and the effect of dupilumab treatment
Authors:   , Achten Roselie Edith
Published: October 2023

This thesis discussed ocular surface disease (OSD) in patients with atopic dermatitis (AD) and the effect of dupilumab treatment. The clinical characteristics, risk factors and pathomechanism of OSD were investigated. It was found that 90% of patients with moderate-serious AD already had OSD, and that these patients had fewer conjunctival goblet cells compared with healthy controls. Also, we found higher biomarkers related to the severity of AD in the tear fluid of patients with moderate-to-severe OSD compared to patients with no or mild OSD.
During dupilumab treatment, the function of these goblet cells decreased. Eyelid eczema appeared to be associated with developing OSD both before and during dupilumab treatment. Also, we found that dupilumab reached the eye, as dupilumab was detectable in the tear fluid of dupilumab-treated AD patients. Examination of patients' tear fluid showed that patients with more severe OSD during dupilumab treatment had higher dupilumab tear fluid levels. Early treatment or adjustment of the dupilumab dosing interval may help improve these ocular abnormalities. A multidisciplinary approach to these ocular abnormalities involving both dermatologists and ophthalmologists is important to early diagnose and treat OSD.
Everlasting flowers between the pages: Forms of knowledge and the making of seventeenth-century florilegia
Authors:   , Chen Wei-Hsuan
Published: October 2023

The florilegium is a genre of images that visually documented flowers and decorative plants that were rare and curious in the long seventeenth century (ca. 1550–1725). Flowers such as tulips, narcissi, sunflowers, and many more kinds of colorful species and their varieties, were rarities and curiosities to be cultivated and collected in gardens. These books of flowers were expensive picture books with little text, with the early modern liefhebbers being the main owners and readers. Aside from having them as a status symbol, what was the purpose(s) of producing luscious books with mostly (colored) pictures of flowers? Turning to the makers of florilegia, this research offers new insights into the genre as material objects that highlight and showcase many forms of knowledge. From the gardeners who grew and cultivated the flowers that are the modeled subjects for florilegia; to the compilers who gathered and presented the visual and textual information about rare and curious flowers; to the image makers who drafted and/or colored the images of these floral rarities and curiosities; several kinds of makers contributed their knowledge and expertise to produce living specimens and immortalize rare and curious flowers on papers and parchments. To better understand what kinds of knowledge and expertise makers of florilegia had, this research engages with hands-on and performative methods. By remaking selected florilegium pages and reworking historically oriented horticultural techniques, this research unpacks how different forms of practices and practical knowledge came together to create everlasting flowers between the pages.
Comparison of palliative care education for family caregivers in high-and-low-income countries: An integrative review
Authors: Kristanti Martina Sinta , Hidayati Nurdina Wahyu , Maryadi
Published: October 2023

Background: In most resource-limited countries, palliative care is still under development. Despite the differences, the involvement of family caregivers is fundamental in both High-Income Countries (HICs) and Low-Income Countries (LICs). The lack of formal support in LICs implies that educational interventions to support family caregivers in this region could be more complex and urgently needed than in HICs. To comprehend the existing situation and identify the gaps in LICs, using HICs as a benchmark standard and conducting a review comparing educational interventions in both regions is essential.
Objective: To identify and compare the existing implementation of education for family caregivers of patients with advanced cancer in LICs and HICs.
Design: An integrative review guideline by Whittemore and Knafl was followed. Interventional studies related to education for family caregivers providing care for adult patients with cancer were included, and review articles were excluded.
Data Sources: Data were obtained from PubMed, EBSCO, ProQuest, and ClinicalKey. The search was conducted on 18 November 2021 and updated on 9 August 2023.
Review methods: Data reduction, data comparison, conclusion drawing, and data verification were conducted.
Results: Out of the 11 studies included, nine were randomized controlled trials, and two were quasi-experimental studies. Among them, seven (63%) were conducted in HICs, and four (37%) were carried out in LICs. In both regions, the psychological aspect was the most commonly addressed subject in palliative care education for family caregivers. However, in LICs, no articles specifically addressed the social and spiritual aspects of family caregivers’ education. Research conducted in LICs mostly involved nurses, while studies in HICs included a more diverse range of healthcare professionals. Typically, these programs required two to three sessions, with 30-60 minutes duration for 3-12 weeks.
Conclusion: The social and spiritual aspects can be integrated into family caregivers’ training programs in LICs in the near future. Nurses, as an integral part of the multidisciplinary team, are capable of contributing to the development of educational programs for family caregivers, especially in resource-limited countries where patients rely heavily on their caregivers and relatives. Support from nurses is fundamental in such contexts.
Exploring the aftermath: Work demands, workplace violence, and job satisfaction among nurses in a public hospital in the post-COVID-19 era
Authors: Sulistyowati Dita , Handiyani Hanny , Kurniawan Moh Heri , Syukrini Rahma Dwi , Turyatiningsih
Published: October 2023

Background: Despite the shift from the COVID-19 pandemic to an endemic phase, many individuals, including nurses, may still be facing psychosocial challenges after enduring three years of the pandemic. Although the anticipation that psychosocial issues, such as work demand and workplace violence, have diminished and nurses’ job satisfaction has improved, there is a scarcity of studies in Indonesia investigating this matter.
Objective: This study aimed to 1) explore the current state of nurses’ work demands, workplace violence, and job satisfaction and 2) examine the relationships between work demands, workplace violence, and respondents’ characteristics with nurses’ job satisfaction.
Methods: The study employed a cross-sectional survey design involving 247 nurses from a regional general hospital in Jakarta, Indonesia. Simple random sampling was used to select the participants, and the Copenhagen Psychosocial Questionnaire (COPSOQ) III was used for data collection. Data were analyzed using multiple linear regression.
Results: The types of cognitive demands (M = 12.46, SD = 3.461), demands for hiding emotion (M = 11.66, SD = 3.554), and work pace (M = 9.87, SD = 2.847) scored an average close to or within the “sometimes/quite extensive” range on the scale. All types of workplace violence and conflicts occurred among nurses (Mean range = 1.21-2.57). Nurses perceived themselves as fairly satisfied with their job (M = 18.47, SD = 3.18). The results of the multiple linear regression indicated that nurses’ job satisfaction was predominantly influenced by workplace violence (β = -0.191), followed by the type of care unit (β = -0.167) and work demands (β = -0.126). These factors collectively accounted for 9.1% of the variance in the job satisfaction variable (R2 = 0.091, p <0.005)
Conclusion: Despite the decreasing number of COVID-19 cases, nurses still experience high work demands and continue to face workplace violence. These factors, as well as the type of care unit, influence nurses’ job satisfaction. Therefore, further actions need to be taken by hospital management to address these psychosocial conditions. It is recommended that future research explore the role of nurse managers in managing the psychosocial factors associated with these three factors.
Social determinants of health and glycemic control in persons with type 2 diabetes mellitus attending a tertiary hospital in Nepal: A cross-sectional study
Authors: Adhikari Prava , Sriyuktasuth Aurawamon , Phligbua Warunee
Published: October 2023

Background: Diabetes mellitus (DM) is an emerging global public health challenge worldwide, including Nepal. Social determinants of health (SDOH) play a major role in glycemic control among persons with type 2 DM (T2DM). However, little is known about the association between SDOH and glycemic control among individuals with T2DM in Nepal.
Objective: This study aimed to identify the level of glycemic control and SDOH associated with glycemic control among Nepalese with T2DM.
Methods: This cross-sectional study was conducted at a tertiary hospital in Kathmandu, Nepal, among 135 Nepalese diagnosed with T2DM who attended follow-up appointments. Convenience sampling and inclusion criteria were utilized for participant selection. Data were collected from April to June 2021 using validated scales. Descriptive statistics, Chi-square test, and binary logistic regression were employed to analyze the data.
Results: The mean age of the participants in this study was 53.84 (SD = 11.78) years, and the average monthly household income was 567.64 (SD = 362.30) USD. The majority of the participants (77.8%) were literate and had no health insurance coverage (73.3%). Approximately 64.4% of the participants showed suboptimal glycemic control indicated by glycated hemoglobin (HbA1c) ≥7%. The significant determinants of good glycemic control included monthly household income of  >850 USD (odds ratio  [OR] = 12.20, 95% confident interval [CI] = 1.76–84.61, p = 0.011) and 341–600 USD (OR = 7.64, 95% CI 1.35–42.98, p = 0.021), being literate (OR = 6.37, 95% CI = 1.65–24.49, p = 0.007), having health insurance (OR = 5.82, 95% CI = 1.49–22.65, p = 0.011), sufficient health literacy (OR = 3.46, 95% CI = 1.10–10.83, p = 0.03), and high (OR = 16.17, 95% CI = 2.36–110.67, p = 0.005)  and moderate (OR = 7.02, 95% CI = 1.26–39.07, p = 0.026) food availability, respectively.
Conclusion: The study revealed suboptimal glycemic control in Nepalese with T2DM. This study presents essential social determinants of glycemic control in this population. Therefore, healthcare providers, particularly nurses, should pay more attention to assessing social determinants and provide targeted interventions to patients with T2DM who have low income, are illiterate, have no health insurance coverage, have insufficient health literacy, and have low resources for food availability.
Experiences of Indonesian nurses in improving preterm oral feeding readiness in special care units: A qualitative descriptive study
Authors: Astuti Dyah Dwi , Rohsiswatmo Rinawati , Wanda Dessie , Utari Diah Mulyawati
Published: October 2023

Background: Many preterm infants face feeding difficulties during the transition from enteral to oral feeding due to organ immaturity, resulting in aspiration, airway instability, and oral feeding intolerance. These challenges can increase morbidity and mortality among preterm infants. Nurses play a vital role in providing interventions to minimize negative impacts and enhance the safety of preterm oral feeding.
Objective: This study aimed to explore the experiences of Indonesian nurses in improving preterm oral feeding readiness.
Methods: A qualitative descriptive study was conducted involving ten nurses working in intensive care units as participants through purposive sampling. Data were collected through semi-structured, in-depth interviews conducted from January to March 2023. Thematic analysis was applied for data analysis.
Results: Four key themes developed in this study: 1) comprehensive and holistic nursing assessment, 2) challenging and complex nursing issues, 3) the need for nutritional management skills, and 4) the necessity of collaborative support.
Conclusion: Nurses play a pivotal role in enhancing oral feeding readiness among premature infants. Their responsibilities include assessing oral feeding readiness, addressing nursing challenges, and implementing multidisciplinary stimulation involving parents. This study provides a foundational framework for developing interventions to improve preterm oral feeding readiness.
Patient compliance: A concept analysis
Authors: Thummak Saowaluk , Uppor Wassana , Wannarit La-Ongdao
Published: October 2023

Background: Patient compliance with regimens is one of the most researched and least-understood behavioral concerns in the healthcare profession due to the many meanings employed in multidiscipline over time. Thus, a thorough examination of the idea of patient compliance is necessary.
Objective: This paper aims to explore and identify the essence of the term patient compliance to achieve an operational definition of the concept.
Method: Walker and Avant’s eight-step approach was used. A literature search was conducted using keywords of patient compliance AND healthcare profession from five databases: PubMed, Medline, CINAHL, ProQuest, ScienceDirect, and Cochrane database, published from 1995 to 2022.
Results: The attributes of patient compliance include 1) self-care behavior, 2) following health recommendations, and 3) willing collaboration with health professionals. Antecedents of patient compliance were characteristics of therapeutic regimens, communication of health advice, and patients’ attitudes toward professional recommendations. Consequences include improved clinical outcomes, quality of life, and lifestyle or behavior modification.
Conclusion: This concept analysis offers a valuable perspective on patient compliance that guides the nursing practice in providing better interventions to promote compliance among patients.
Development and psychometric properties of the Person-centered Palliative Care Nursing Instrument (PPCNI) in the Philippines
Authors: Soriano Gil P. , Calong Calong Kathyrine A. , Martinez Rudolf Cymorr Kirby , Ito Hirokazu , Yasuhara Yuko , Abalos Evalyn , Tanioka Tetsuya
Published: October 2023

Background: Over the years, a few tools and instruments have been developed to assist in the assessment within a palliative care setting. However, many of these tools and instruments do not reflect a person-centered palliative care model.
Objective: This study aims to develop a Person-centered Palliative Care Nursing Instrument (PPCNI) in the Philippines.
Methods: An exhaustive search of the literature was conducted to develop a pool of items for the instrument. The validity of the instrument was evaluated using the content validity index (CVI), while the factor structure was assessed using exploratory factor analysis (EFA) using maximum likelihood estimation with Promax rotation. Also, the internal reliability was evaluated using Cronbach’s alpha.
Results: EFA yielded three factors: 1) Caring as maintaining person’s dignity (13 items), 2) caring as empowerment of person’s autonomy (14 items), and 3) caring as understanding person’s momentary concerns (10 items). Whereas the internal consistency reliability of these subscales appeared excellent (i.e., 0.95, 0.96, and 0.93, respectively), the Cronbach’s alpha for the overall scale was 0.98. The item-total correlation coefficients were >0.30 for all items, ranging from 0.310 to 0.726.
Conclusion: Findings support a three-factor, 37-item PPCNI that can be used in clinical practice to ensure that nurses provide palliative care based on patient needs and preferences.
Double Trisomy 16 and 22 Clinically Mimic Partial Hydatidiform Mole in a Case of Subsequent Pregnancy Loss
Authors: Gergely L , Korbeľ M , Adamec A , Repiská V , Babál P , Melišová K , Priščáková P
Published: October 2023

A case of double trisomy 16 and 22 in the second pregnancy loss is presented. DNA analyses (short tandem repeats genotyping) of miscarriage specimen was indicated because of ultrasound suspicion of partial hydatidiform mole. After the partial hydatidiform mole exclusion, further DNA analyses focused on the most common aneuploidies causing pregnancy loss, detected double trisomy 16 and 22 in the product of conception. The couple was referred to clinical genetic consultation and normal parental karyotypes were proved. For further explanatory purposes, archived material from the first pregnancy loss was analyzed and trisomy of chromosome 18 was detected. By comparison of allelic profiles of the mother, father, and both losses, the maternal origin of all aneuploidies was proven what can be attributed to frequent meiosis errors, probably due to advanced maternal age (44 years at the first loss and 45 years at the second loss). In conclusion, aneuploidies can mimic partial hydatidiform mole. Genetic analysis is helpful on the one hand to rule out partial hydatidiform mole and on the other hand to identify aneuploidies and in this way to determine the cause of miscarriage.
Current Status of the Applications of Conditioned Media Derived from Mesenchymal Stem Cells for Regenerative Medicine
Authors: Smolinská V , Boháč M , Danišovič Ľ
Published: October 2023

Recently published studies suggest that the paracrine substances released by mesenchymal stem cells (MSCs) are the primary motive behind the therapeutic action reported in these cells. Pre-clinical and clinical research on MSCs has produced promising outcomes. Furthermore, these cells are generally safe for therapeutic use and may be extracted from a variety of anatomical regions. Recent research has indicated, however, that transplanted cells do not live long and that the advantages of MSC treatment may be attributable to the large diversity of bioactive substances they create, which play a crucial role in the control of essential physiological processes. Secretome derivatives, such as conditioned media or exosomes, may provide significant benefits over cells in terms of manufacture, preservation, handling, longevity of the product, and potential as a ready-to-use biologic product. Despite their immunophenotypic similarities, the secretome of MSCs appears to vary greatly depending on the host's age and the niches in which the cells live. The secretome's effect on multiple biological processes such as angiogenesis, neurogenesis, tissue repair, immunomodulation, wound healing, anti-fibrotic, and anti-tumor for tissue maintenance and regeneration has been discovered. Defining the secretome of cultured cultivated MSC populations by conditioned media analysis will allow us to assess its potential as a novel treatment approach. This review will concentrate on accumulating data from pre-clinical and clinical trials pointing to the therapeutic value of the conditioned medium. At last, the necessity of characterizing the conditioned medium for determining its potential for cell-free treatment therapy will be emphasized in this study.
Molecular Biomarkers of Bladder Cancer: A Mini-Review
Authors: VARCHULOVÁ NOVÁKOVÁ Z , KUNIAKOVÁ M , ŽIARAN S , HARSÁNYI Š
Published: October 2023

Cancers are quite common, but mostly very serious diseases and therefore belong to the most important areas of scientific research activity. Bladder cancer is one of the most common malignancies, it is a heterogeneous disease with significant diagnostic, therapeutic, and prognostic problems. It represents a disease with a variable course and a different response to therapy. The “conventional” prognostic markers used so far cannot reliably predict the natural course of the disease or estimate the tumor response to the chosen type of treatment. Molecular markers can provide us with the opportunity to diagnose a bladder tumor early, identify patients who are at risk of recurrence, or predict how tumors will respond to therapeutic approaches. As a result, diagnostics are found to help clinicians find the best therapeutic options for patients with bladder cancer. In this study, we focused on a brief description of potential molecular markers in bladder tumors in the context of precise diagnostics. Last but not least, we also focused on a new approach to the treatment of cancer using nanomaterials.
Improving fifth- grade students’ learning outcomes using problem-based learning model in the integrated thematic learning
Authors: Diniyyah Dian , Ningsih Yarisda
Published: October 2023

The study was motivated by the learning process that has not been student-cantered, students were less active in learning, teachers had not applied innovative group-based models, and student learning outcomes were still low. The approach used by researchers in this study was a combination of qualitative and quantitative approach. the method used in this study was classroom action research (CAR). This study was conducted in the first semester of the 2022/2023 school year. The subjects in this study were 23 students. The data source was the process and results of implementing integrated thematic learning with a problem-based learning model. The techniques used were observation, tests and non-tests. The results of the study showed that students’ learning outcomes increased from the learning activities in cycle I to cycle II. This study concluded that the problem-based learning model can improve student learning outcomes in integrated thematic learning.
Optimization design and thinking of new knowledge of primary school mathematics under the perspective of high-order thinking cultivation: Take the surface area of the cylinder as an example
Authors: Zhang Simin , Jie Qin , Pereira Jerito
Published: October 2023

The 20th report clearly emphasizes the importance of training innovative talents, and the cultivation of higher-order thinking has been paid attention to. Micro-lesson is a new teaching method to cultivate and develop students' high-level thinking. Taking cylindrical surface micro-lesson design as an example, this paper, starting from practice, compares the micro-lesson design and fragment record before and after optimization, and puts forward suggestions for optimization design: Pay attention to the construction of knowledge system and develop general thinking; Pay attention to summary reflection, form critical thinking; Pay attention to situation creation and develop innovative thinking; Focus on problem chain design and develop logical thinking. In order to provide reference for primary school mathematics classroom micro-lesson design. In order to provide reference for primary school mathematics classroom micro-lesson design.
Development of monopoly media based on QR-Code on the theme of rich my country
Authors: Sari Lusti Indah , Mulyawati Yuli , Mirawati Mira
Published: October 2023

This study aims to design and develop QR Code-based monopoly media on the subject matter of my rich country in Class IV SDN Sindang Barang 2 Bogor City. This research method is used to produce several products and to test the effectiveness of these products. The design of this study uses the ADDIE model which consists of the stages of Analysis (Problem Analysis), Design (Product Design), Development (Development), Implementation (Implementation), and Evaluation (Evaluation). This study involved media experts, linguists, and material experts to provide assessments as well as students as media users. The results of this study are that monopoly media based on QR Code has received eligibility validation on the aspect of media suitability based on ISO 9126 quality with a percentage of 83.63%, linguistic aspects by linguists with a percentage of 100%, and material aspects for the sake of material experts with a percentage of 96.36%.. Monopoly learning media based on the QR Code also received a positive response from 33 students with a percentage of 90.8% in the "Very Good" category. Based on this description, QR Code-based monopoly media is very feasible and can be implemented for teaching and learning activities with the theme Kaya Negeriku Class IV SD.
Application of the Flipped Classroom Model Using Games-Based Learning Multimedia in Increasing Students’ Learning Outcomes
Authors: Pradikto Bayu , Sofino Sofino
Published: October 2023

This paper discusses the low students’ learning outcomes and students’ satisfaction, which continues to decline. In contrast, distance and face-to-face learning are limited to non-formal education learning technology courses. The study aimed to improve learning in the Non-Formal Education Learning Technology course in the S1 Non-Formal Education Study Program by implementing games-based learning multimedia with the flipped classroom model. The research was conducted on 30 students in semester III/A. By applying the flipped classroom model, the research was conducted in the classroom and at each student's home. The research used a Pre-Experimental Design with a One-Group Pretest-Posttest Design. The data collection technique was carried out by testing. The pre-test was carried out to collect data on students' initial abilities, while the post-test was carried out to test the effect of the treatment. The study used three statistical tests, namely (1) normality, (2) homogeneity, and (3) hypothesis testing. The results indicate that the control class sample data were normally distributed. After treatment, initial data on students' abilities are interpreted as normal or homogeneous. The results of hypothesis testing show that there is a significant effect of flipped classrooms based on game multimedia in non-formal education learning technology courses with an average value of the experimental class at 81.63.
The Effect of Student Team Achievement (STAD) Cooperative Learning Model on the Fourth-Grade Students’ Learning Outcomes at Assisi Medan Elementary School
Authors: Kristina Saskia , Lumbanraja Bogor , Silaban Patri Janson , Gaol Rumiris Lumban , Juliana Juliana
Published: October 2023

This paper discusses the effect of applying the Student Team Achievement Division (STAD) cooperative learning model on student learning outcomes on the theme of the area where I live in class IV of SD Assisi Medan in the academic year 2022/2023. The research uses quantitative methods. The research population involves 180 fourth-grade students at SD Assisi Medan. The sampling used simple random sampling and the sample used was 44 fourth-grade students. The research results indicate that students’ learning outcomes using the Student Team Achievement Division (STAD) cooperative learning model are in the very good category with an average score of 83.48. The correlation test result is 0.958, which means rcount (0.958) ≥ rtable (0.297), so that Ha is accepted. Thus, there is a significant effect between the use of the Student Team Achievement Division (STAD) cooperative learning model on students’ learning outcomes on the theme of the area where I live in class IV of SD Assisi Medan. It can be seen from the results of the T-test research where tcount 21,720 ≥ ttable 2,015 so it can be stated that Ha is accepted. It indicates that there is a significant positive effect from the use of the Student Team Achievement Division (STAD) cooperative learning model on students’ learning outcomes on the theme of the area where I live in class IV of SD Assisi Medan in the academic year 2022/2023.
The Relationship Between Teacher's Communication Skills and Students’ Learning Interest in the Fourth-Grade Social Science Learning Subject in Elementary School
Authors: Sirait Eirene , Lumbanraja Bogor , Silaban Patri Janson , Anzelina Dewi , Sitepu Anton
Published: October 2023

This paper discusses the relationship between teacher communication skills and students’ learning interest in social science learning subjects. The research was conducted in class IV at SD Negeri Medan Johor. Researchers used associative quantitative research methods. The population used was 36 students at class IV SD Negeri 060938 Medan Johor. Sampling used saturated sampling. The research results indicate that the results obtained from the correlation test can be seen in the correlation coefficient,  rcount 0.946 ≥ rtable 0.329. Hence, it can be concluded that the alternative hypothesis (Ha) is accepted where there is a significant relationship between communication skills and students' learning interests at SD Negeri 060938 Medan Johor. In addition, it can be seen from the results of the t-test where tcount 17.052 ≥ ttable 2.030, hence the hypothesis (Ha) is accepted. It shows that there is a positive significant relationship between teacher communication skills and students’ learning interests in social science learning subjects in class IV at SD Negeri Medan Johor in the academic year 2022/2023.
Giving Rewards as an Attempt to Increase Teacher Motivation at SDN 006 Kota Baru Kampar
Authors: Sukardi Ahmad
Published: October 2023

This paper investigates a study that aims to find out whether motivational achievement can be increased through giving rewards at SDN 006 Kota Baru Kampar or not. If the teachers have motivational achievement, they will carry out their work seriously to achieve the success of the organizational goals that have been determined. In addition, the focus of the research is related to reward giving as an attempt to increase teachers’ motivational achievement. The research is school action research (PTS), which was carried out at SDN 006 Kota Baru Kampar. The research subjects involved 19 teachers. The research was conducted in two cycles. Based on the description of data processing and discussion, it is concluded that motivational achievement can be increased through giving rewards at SDN 006 Kota Baru Kampar. It can be seen from the aspect of giving rewards presented by the teachers, which indicates that it increased from cycle I to cycle II. If the average score indicates 20 in cycle I, then it increases to the average score of 32 in cycle II. In terms of teacher motivational achievement, it is found that in cycle I the average percentage is 52.6% with a fairly good category and in cycle II it increases to 86.8% with very good category.
Basic Teaching Skills for Teachers at SD GP Kumelembuai
Authors: Mesra Romi , Tagaku Afriono , Simbar Triven , Wangkanusa Seltia , Mangar Siska , Podung Olvinia A. C , Andale Anjelita
Published: October 2023

This paper discusses a study that takes a closer look at how educators carry out the teaching and learning process using curriculum development and basic education evaluation systems that have been implemented properly. Basic teaching skills are important for teachers to know and implement. It is related to the effectiveness of the teacher in the teaching and learning process carried out in learning. The purpose of the research is to describe how basic teacher-teaching skills are implemented at SD GP Kumelembaai. The research is a descriptive qualitative research. The research data and findings come from the value of skills that form the basic education of grade 1, 2, and 3 teachers at SD GP Kumelembai. The data collected are data about the basic teaching skills of teachers through the stages of observation, interviews, and documentation. Based on the research findings and basic teaching skills, teachers in remote areas, especially at SD GP Kumelembai, are not yet skilled in applying basic teaching skills in learning, such as opening and closing lessons, asking questions, explaining, guiding small group discussions, teaching individually, managing classes, providing reinforcement, and providing variety.
Evaluation of the reliability and accuracy of femur measurements acquired from computed tomography images
Authors: GÜLHAN Öznur
Published: October 2023

The biological profile holds notable significance within forensic assessments, as it plays a crucial role in determining biological identity. Moreover, it possesses substantial potential for applications in fields such as medical legal cases and forensic anthropology. Recent advancements in technology, specifically in the field of computed tomography, have enabled the accurate acquisition of detailed anatomical data from CT scans present in extensive medical repositories. The validity of new methods developed through the application of these techniques should therefore be analyzed. The primary intent of this research was to investigate the measurement accuracy obtained from CT-generated 3D femur models. To investigate the accuracy and reliability of measurements obtained from CT-generated 3D femur models, 3 different studies were conducted. A dataset comprising fifteen femurs was employed for analysis and measurement purposes. The obtained images were subsequently compared to twelve measurements acquired from the dry femora, enabling an assessment of the reliability and accuracy of both measurement protocols. To investigate the effect of CT parameters and soft tissue, 4 femurs were used. The analysis of twelve femur measurements obtained from the CT images processed with OsiriX software was carried out using Excel software packages and SPSS 24.0. From the results of this study, it can be observed that there is no discernible pattern regarding the reliability of image acquisition in any particular way. This implies that both dry femur bone and 3D virtual femur models can be used interchangeably for the 12 metric measurements used in this study, and at the same time, different scanning parameters or soft tissue influence for these measurements do not make a statistically significant difference.
ROMA HUKUKUNDA AKIL HASTALARININ FİİL EHLİYETİ
Authors: ÖZYILDIRIM Mehmet Mert
Published: October 2023

Fiil ehliyeti kavramı, kişinin kendi fiilleri aracılığıyla hukuki sonuç doğurabilecek işlemleri bizzat yapabilme salâhiyetini ifade etmektedir. Akıl hastalarının, her ne kadar belirli koşullarda hak ehliyetine sahip olmaları mümkün olsa da Roma Hukuku’nun Eski Hukuk Dönemi’nden beri fiil ehliyetlerinin kısıtlanması gerektiğine karar verilmiştir. Bu kapsamda, ilgili kişilerin malvarlıklarının yönetimi açısından kendilerine bir kayyım (curator furiosi) tayin edilmesi uygun görülmüştür. Tayin edilen kayyımların, akıl hastasının hukuki işlemlerine izin veya onam vermesi yetmemekte, fakat bu işlemleri akıl hastası adına bizzat kendilerinin yapması gerekmektedir. Ancak istisnai olarak, akıl hastalarının bizzat kendi fiilleri sonucunda taraf olabileceği hukuki işlemler de mevcut olduğu için konunun dikkatlice irdelenmesi önem arz etmektedir. Bu bağlamda çalışmada, öncelikle akıl hastalığının tanımına yer verilerek Roma Hukuku’ndaki terminoloji sorunu üzerinde durulmuş, daha sonra hastalığın teşhis edilmesi ile curator atanması süreçleri incelenmiş, son olarak da bu kişilerin fiil ehliyetinin kısıtlanmasının hukuki sonuçları, aile hukuku, borçlar hukuku ve eşya hukuku kapsamında ayrı ayrı ele alınmıştır.
ÜRÜN GÜVENLİĞİ VE TEKNİK DÜZENLEMELER KANUNU’NDA YER ALAN ÜRÜN SORUMLULUĞU KURALLARI İLE ÜRÜN GÜVENLİĞİ KURALLARININ İLİŞKİSİ
Authors: KARAŞAHİN Yasin Alperen
Published: October 2023

Ürün Güvenliği ve Teknik Düzenlemeler Kanunu, imalatçıları ve başka bazı iktisadî işletmecileri piyasada bulundurdukları tehlikeli ürünlerin kişiye ve eşyaya verdikleri zarardan kusur aramaksızın sorumlu tutmaktadır. Söz konusu kanun, ürün güvenliğine dair hükümler ile ürün sorumluluğuna dair hükümleri ortak kavramlara dayalı olarak ve iç içe geçmiş bir şekilde düzenlemiştir. Bu nedenle, ürün sorumluluğuna dair hükümler yorumlanırken ürün güvenliğine dair düzenlemelerin de dikkate alınması ve her iki hukuk alanına uygun olacak şekilde kanun hükümlerinin yorumlanması gereklidir. Ürün kavramının tanımında kullanılan “eşya” kelimesi “emtia” olarak anlaşılmalıdır. Ürün sorumluluğunun doğması için ürünün uygunsuz olması yerine tehlikeli olması (güvenli olmaması) şartı kabul edilmelidir. Ürün hem normal kullanımı hem de makul olarak öngörülebilen normal dışı kullanımı sırasında güvenli olmalıdır. Teknik düzenlemelere uygunluk sorumluluktan kurtuluş sebebi teşkil etmemektedir. Zarar gören, ürünün olağan veya makul olarak öngörülebilen olağandışı kullanımı sırasında zarara sebebiyet verdiğini ispat ederse, ürünün tehlikeli olduğu ve tehlike ile zarar arasında nedensellik bağı bulunduğu yönünde bir fiilî karine kabul edilmelidir.
EVALUASI PELAKSANAAN PERATURAN DAERAH KABUPATEN SUKOHARJO NOMOR 12 TAHUN 2020 TENTANG KABUPATEN LAYAK ANAK DALAM PEMENUHAN HAK ANAK
Authors: Destiawan Risqi Ibnu , Eviany Eva
Published: October 2023

Berbagai kegiatan telah dilaksanakan dan beberapa penghargaan telah diraih dalam penerapan Program Kabupaten Layak Anak (KLA) dalam rangka perlindungan anak di Kabupaten Sukoharjo. Namun, masih ditemukan permasalahan dalam pemenuhan hak anak, seperti kasus kekerasan terhadap anak, kasus stunting, dan kasus pernikahan dini. Penelitian ini bertujuan untuk mendeskripsikan dan menganalisis evaluasi serta faktor pendukung dan penghambat pelaksanaan peraturan daerah ini di Kabupaten Sukoharjo. Metode penelitian adalah metode penelitian kualitatif deskriptif melalui wawancara kepada 17 orang informan, dan dokumentasi. Hasil penelitian ini menunjukkan bahwa secara umum pelaksanaan Program KLA di Kabupaten Sukoharjo sudah berjalan sesuai dengan kebutuhan/hak anak dan peraturan yang ada, tetapi masih terdapat beberapa kekurangan seperti terbatasnya sarana dan prasarana, serta sumber daya manusia, dan masih minimnya pemahaman masyarakat terkait program KLA ini. Pemerintah Kabupaten Sukoharjo diharapkan lebih memberikan perhatian pada pemenuhan hak anak melalui pelaksanaan Program KLA, sehingga pemenuhan hak anak di Kabupaten Sukoharjo dapat lebih maksimal.

 

 

Kata Kunci: Evaluasi; Program; Kabupaten Layak Anak; Pemenuhan Hak Anak.