bluuebunny/crossref_metadata_2025 huggingface dataset:
The use of high-resolution photogrammetry for the survey and analysis of rock-climbing walls
Authors: Ruess Stefan , Paulus Gernot , Anders Karl-Heinrich
Published: June 2022

Abstract. In climbing, the routes that lead through a wall are mainly represented in two-dimensional maps. These climbing maps, also called "topos," help climbers and alpinists to plan their routes and find a way through the complex structures of a vertical or partially overhanging rock face. Today, a trend towards more realistic visualization techniques can be seen, where 3D representations are used for different geometric and topographic features (Kolecka, 2012). In this paper the focus is on 3D visualization and high-resolution data capturing at rock walls. Unmanned Aerial System (UAS) - based data collection has been conducted to collect digital images that are used to generate various outputs using a photogrammetry workflow. The photogrammetric processing of digital imagery results in dense 3D point clouds, digital surface models (DSM), textured 3D models and orthophotos of the test sites. How accurately is it possible to survey a vertical rock and how high the spatial resolution of the outputs will end up being is answered in this paper. After the data collection and the photogrammetric processing, a 3D climbing guide is created to answer the question if an enhanced visualization of climbing routes can be achieved. There are certain morphological features within the rock face that play a major role in climbing. For one, the climbing holds are important for climbers to continue the movement upwards. Other important factors are the dip angle and the dip direction of different rock facets. In this thesis the 3D point cloud is clustered into different sized facets, that share the same dip angle which is the angle of the center point of a cluster to a horizontal plane and the same dip direction which is the orientation of such a facet(Thanh, 2008). Using the analysis results, an automated climbing route construction is performed.
Geodata source retrieval by multilingual/semantic query expansion: the Case of Google Translate and WordNet version 3.1
Authors: Sajjadian Maryam , Scheider Simon
Published: June 2022

Abstract. In this article, we examined the potential of the current version of WordNet and Google Translate API to enhance the quality of geodata source retrieval in the Dutch geoinformation portal (PDOK) using semantic keywords for the geographic phenomena requested. Keywords gathered from real users’ questions in natural language extracted in an English corpus. Then, these keywords were expanded using WordNet and Google Translate API. Lastly, the results of query expansion were evaluated compared to a manual gold standard and based on information retrieval metrics. Our study shows that the results of query expansion help users by reformulating good alternative queries.
Rule-Based Quality Assurance Tool for 3D Buildings
Authors: Turunen Alpo
Published: June 2022

Abstract. This article presents a Data Quality Assurance (DQA) tool for 3D city buildings, which is developed using the FME Workbench application. It evaluates the quality of both CityGML and CityJSON data sets against predefined rules and produces quality information in the tabular or geometrical format. All violations are categorized based on their severity, which means that the tool can automatically discard or fix some of the found errors. By doing so, the tool can play an important role in Spatial Data Infrastructures (SDI) and improve data integration processes by improving data quality and interoperability.
Open source vector tile creation for spatial data infrastructure applications
Authors: Wallner Andreas Georg , Piechl Thomas , Paulus Gernot , Anders Karl-Heinrich
Published: June 2022

Abstract. Accessing geospatial data via the internet is a common way for data integration. This web mapping approach often relies on web services like the web map tile service (WMTS) for accessing maps or the web feature service (WFS) for accessing vector data. An alternative way, which combines aspects like the higher performance through tiling and the usage of vector data is the usage of tiled vector data. This short paper describes an approach for the creation of tiled vector data using standard PostgreSQL, with spatial extension PostGIS, functionality. For that, custom PostGIS functions are implemented to select relevant vector data out of the PostgreSQL database, dynamically generalize/simplify geometries and transform the data to Mapbox mvt format. This approach of creating tiled vector data shall be used for further implementations of web maps for building more efficient spatial data infrastructures.
A web-based application to support the interaction of spatial and semantic representation of knowledge
Authors: Zacharopoulou Dimitra , Kokla Margarita , Tomai Eleni , Kavouras Marinos
Published: June 2022

Abstract. The visualization of semantic information provides new ways for knowledge acquisition and access, since it enables users to explore and understand the meaning of information, as well as to identify associations among data and connections to existing knowledge. Maps on the other hand are extensively used as symbolic representations of spatial reality. Lately, researchers have delved deeper into formalizing the connection between the map and the semantics it conveys using knowledge-based formalisms such as knowledge graphs, ontologies, and linked data. Semantic visualization techniques may also enrich maps with the knowledge immanent therein and support knowledge visualization and exploration.The present paper describes the development of a web-based prototypical application that contains a spatial and a semantic component that interact. In addition to the representation of geospatial entities as cartographic features, the graph-based representation of semantic information is also implemented, to enable users to explore and understand the meaning and semantic relations between concepts and entities that appear on the map.
Towards geospatial blockchain: A review of research on blockchain technology applied to geospatial data
Authors: Zhao Pengxiang , Cedeno Jimenez Jesus Rodrigo , Brovelli Maria Antonia , Mansourian Ali
Published: June 2022

Abstract. In recent years, geospatial big data has been generated at a very high speed, and the data volume is becoming increasingly massive. In order to realize the full potential of geospatial big data, there has been a strong requirement and push to embrace the value of open science. However, it is still challenging to preserve the privacy and integrity of geospatial data in data sharing and management. Blockchain as d distributed ledger technology has a series of good characteristics, such as decentralization, trust-free, transparency, tamper-free, consensus and security, etc. These characteristics of blockchain are beneficial for facilitating geospatial data sharing and management, and hence promoting the development of open GIS. In this paper, we provide a comprehensive review on the literature that involves how blockchain technology is applied to geospatial data, especially in geospatial data privacy and integrity preservation. First, the background knowledge on geospatial data privacy and blockchain technology are introduced. Then, we reviewed how blockchain technology is applied to geospatial data, followed by the conclusion of the topic. This review is beneficial for understanding how blockchain technology can be applied to geospatial domain by integrating geospatial technologies like GIS and remote sensing.
Review: Safet Bandžović (urednik), Vrijeme i pamćenje: Muslimanske rezolucije 1941, Zbornik radova, Bošnjački institut – Fondacija Adila Zulfikarpašića, Sarajevo 2021, 207 str.
Authors:   Ministry of Civil Affairs of Bosnia and Herzegovina, Veladžić Edin
Published: June 2022

Review: Safet Bandžović (urednik), Vrijeme i pamćenje: Muslimanske rezolucije 1941, Zbornik radova, Bošnjački institut – Fondacija Adila Zulfikarpašića, Sarajevo 2021, 207 str.
Conference Report: Izvještaj sa Naučne manifestacije „Historijski pogledi 4“, Centar za istraživanje moderne i savremene historije Tuzla, Tuzla, 19. i 20. novembar 2021. godine
Authors:   Center for Research of Modern and Contemporary History Tuzla, Jajčević Jasmin
Published: June 2022

Conference Report: Izvještaj sa Naučne manifestacije „Historijski pogledi 4“, Centar za istraživanje moderne i savremene historije Tuzla, Tuzla, 19. i 20. novembar 2021. godine
Educational life in Sarajevo of the Ottoman era: Charity work of the citizens in the 18th and 19th century for the benefits of maktabs
Authors:   Faculty of Philosophy, University of Sarajevo, Filan Kerima
Published: June 2022

This paper explores how citizens took part in educational opportunities in the Ottoman Empire with their endowments (waqfs). The focus is on the charity work for the benefit of maktabs in the City of Sarajevo in the Ottoman Era. The paper expounds on the contribution the citizens made to maktabs – the institutions which provided elementary education for the children and youth. The time period the paper examines is 18th and 19th centuries, and the occasion is the event that took place in 1697, when Sarajevo was devastated under the attack of the Austrian Army. The research is based on waqfs dating back to those centuries, the records of which, predominantly in the form of transcripts, may be found in the Archives of the Gazi Husrev-Bay's Library in Sarajevo. It is indicated that over the period of several decades of the recovery of Sarajevo from the suffering of 1697, maktabs were rebuilt and supported for the greater part from endowments made by the citizens of Sarajevo, who donated their own property. In addition to rebuilding those maktabs which had been built next to mosques in the previous centuries, the citizens of Sarajevo also set up independent maktabs, away from the complex of a mosque. The endowments reveal that a rather widespread form of educational support provided by the citizens benefactors, both men and womene, was to allocate the income from an endowment for the teacher salaries. In that way, income for teachers was supplied in situations when the fundamental waqf from which a maktab was supported had been depleted. Examples show that benefactors assigned appropriate duties to the teaching staff in their waqf, which secured them (muallims) additional income. Support to educational opportunities was also reflected in giving gifts to students. Some benefactors specified that a portion of the income from an endowment was to be used to buy clothes for underprivileged students. Most often, students of a maktab, as well as other poorer inhabitants of a street block (mahalla) received from a waqf free bread, particularly in the holy days. The paper reveals that some citizens of Sarajevo allocated in their last will a one-off aid to maktabs from their inheritance. It also presents examples of private maktabs which were set up by wealthy, learned citizens to educate young people. Charity in general, particularly the one which was donated through the institute of waqfs, represented an important aspect of the activities of citizens in the Ottoman period. With those actions for the benefit of maktabs they supported educational opportunities in their own social communities. It was that very form of charity work that the citizens of Sarajevo maintained in the decades that followed after the end of the Ottoman rule.
COMPRESSION STRENGTHS CORRESPONDENCE OF CONCRETES ACCORDING TO THEIR CLASSES AND MARKS
Authors:   Technical University of Moldova, Croitoru Gheorghe
Published: June 2022

The article presents the problems related to the application of the provisions of the new European standards EN for concrete production, after the withdrawal of the obsolete national standards GOST regarding the correspondence of the classes to the concrete marks. In the context of the application of harmonized standards, there has been a need to establish the correspondence of classes to concrete marks, in order to help design and construction companies to correctly establish the strength mark of concrete to the corresponding class of concrete. The concrete class establishes the normative resistance of concrete for the calculation of constructions, for the service limit state, the prismatic resistance to compression adopted as normative resistance. The ratio between concrete classes and marks, in terms of compressive strength, is determined by the normative coefficient of variation V = 13.5%. The degree of homogeneity of the quality of the concrete is determined according to the values of the standard deviation σ and the average compressive strength of the concrete. As a result of the research, intermediate classes of concrete have been identified, which are not indicated in the normative documents, related to the production of concrete.
PERSPECTIVES FOR THE USE OF BIOMASS GENERATED BY SOME MISCANTHUS GENOTYPES IN THE PRODUCTION OF DENSIFIED SOLID BIOFUELS
Authors:   State Agrarian University of Moldova, Daraduda Nicolae , Marian Grigore ,   State Agrarian University of Moldova
Published: June 2022

Miscanthus is a Poaceae family perennial crop of C4 bioenergy characterized by the multilateral use potential, including the production of biofuels. The paper aimed to study the opportunity to use the biomass generated by two Miscanthus genotypes: Miscanthus × giganteus and Miscanthus sinensis in the production of densified solid biofuels. We quantified the biomass generated by crops that were 5 years old, harvested from both genotypes after the vegetation period, the year 2020. Samples were taken from the experimental lots of the Alexandru Ciubotaru National Botanical Garden (Institute) from the Republic of Moldova in autumn, immediately after the initial onset of senescence and in spring of the following year, before the start of the growing season. The results showed that the above-ground biomass generated by both Miscanthus genotypes harvested in spring had had significantly higher quality characteristics compared to the biomass harvested in autumn. Virtually all qualitative indices of the Miscanthus × giganteus biomass harvested in spring comply with the requirements of the ENPlus international standards for densified solid biofuels. The Miscanthus sinensis biomass, both, had lower indices than the Miscanthus × giganteus biomass from both qualitative and quantitative points of view and the former can be used as a filler in various mixtures of raw material for the production of solid biofuels.
SYNTHESIS AND IMPLEMENTATION OF BIOGAS PRODUCTION IN WASTEWATER TREATMENT PLANT
Authors:   Technical University of Moldova, Moldovan Artiom
Published: June 2022

In this paper, the problem was to carry out a study on the process of mass production of biogas and to deduce the analysis of an example implemented in the wastewater treatment plant. The main problem is the correct processing of the activated sludge and the extraction of the biogas with its basic components. The method described in the paper is current as a technology in the biogas production industry by treating activated sludge from a wastewater treatment plant. For the extraction of biogas according to EU standards and the possibility to use it at each stage of extraction, methods and technologies specific to this process are used and explained.
THE INFLUENCE OF MICROORGANISMS ON BEER QUALITY
Authors:   Technical University of Moldova, Sclifos Aliona , Scutaru Iurie ,   Technical University of Moldova
Published: June 2022

The paper investigated the influence of microorganisms on the quality of Oettinger and Timișoreana beer, in the context of improving the manufacturing methodology of the finished product. Two types of yeast were used for fermentation: Oettinger and SAB-5. At the end of the fermentation process, the microbiological sample was selected to determine the anaerobic bacteria harmful to the beer. Various methods of seeding and sampling were analyzed, such as seeding on several types of media: Wort, Endo and NBB-A, media used to determine the types of microorganisms present at each stage of production. As the level of free amino acids (FAN) is a significant indicator of the completion of the fermentation process, the influence of FAN on the dissociation of yeast and diacetyl content was also analyzed. Subsequently, at the end of the fermentation process, microbiological growths were determined.
The Effect of Machiavelli Leadership on Destructive Organizational Behaviors Through Mediation Job Stress
Authors: HAMMALİ Abdolhakim , NASTİEZAİE Naser
Published: June 2022

The purpose of this study was to investigate the effect of Machiavelli leadership on destructive organizational behaviors through mediation job stress. This study is an applied and correlation research method based on structural equation modeling. 191 elementary school teachers of Sarbaz city were studied by stratified random sampling method. To collect information, three questionnaires were used: Machiavelli leadership, job stress and destructive organizational behaviors. For data analysis the Pearson correlation coefficient and structural equation modeling were used by SPSS and Lisrel software. Based on the results the direct effect of Machiavelli leadership on destructive organizational behaviors, the direct effect of Machiavelli leadership on job stress and the direct effect of job stress on destructive organizational behaviors was positive and significant. The indirect effect of Machiavelli leadership on destructive organizational behaviors was also positive and significant with the mediator role of job stress. Thus, can conclude that managers with high Machiavelli increase staff job stress and job stress, in turn, increases destructive organizational behaviors.
The Role of Workplace Spirituality in Reducing Organizational Hypocrisy in Schools
Authors: SARUHAN Vildan , ÇINAR Seval Erden
Published: June 2022

In this research, the serial mediating effect of interaction anxiety and insight in the relationship between self-esteem and approval dependence in university students was examined. The study group of the research consists of 511 university students. Research data was collected via “Two-Dimensional Self-Esteem Scale”, “the Scale of Interpersonal Relationship Dimensions”, “Interaction Anxiousness Scale” and “Insight Scale”. Descriptive statistics were used in the analysis of the data, while Pearson Correlation Coefficient was used in determining the relationship between the variables, and Bootstrap method was used to test the mediation model. According to the mediation analysis results, it was revealed that interaction anxiousness and insight functioned as mediation variables in the relationship between self-esteem and approval dependence. According to the findings, increase in self-esteem causes a decline in interaction anxiousness, which causes an increase in insight, which in turn leads to a decline in approval dependence. Findings related to the model that was tested were discussed in accordance with the literature. Suggestions for researchers and field practitioners were listed. here to enter text.
Advice for Academician Mothers with Only Child: "I Wish He Had A Brother"
Authors: BATMAZ Hasan , ULUSOY Yağmur
Published: June 2022

The purpose of this research is to reveal what kind of reactions academic mothers get from having a only child and their thoughts on having a child again. In this study, descriptive phenomenology design, one of the qualitative research designs, was used. The study group of research was composed of 9 academician mothers (32-51 age range; age range at marriage: 22-35; duration of the marriage; between 7-23 years) with an only child (5-25 age range), using the criterion sampling method, which is one of the purposive sampling methods. Inclusion criteria for the research; They are academicians who have a child of at least 5 years old and have only child. A semi-structured interview was used to collect the data. Content analysis was used to analyze the data collected. As a result of the analysis, the theme of "I wish he had a brother" was reached. As a result, it has been seen that academic mothers with one child are supported by their spouses to have one child; however, most of them want to have a second child. tap here to enter text.
Real-world analysis of the effect of gefitinib as a first-line therapy in patients with advanced non-small cell lung cancer with EGFR mutations
Authors: Luan Pham Van , Tien Nguyen Dinh , Hai Nguyen Minh , Tien Nguyen Dao , Duyen Thi Thi
Published: June 2022

Objective: To evaluate the effect of gefitinib as a first-line therapy in patients with advanced non-small cell lung cancer (NSCLC) who were positive for epidermal growth factor receptor (EGFR) mutations. Subject and method: This prospective analysis included 120 patients with advanced NSCLC with EGFR mutations who were administered gefitinib as the first-line therapy. Patient follow-up and evaluation were performed every three months or when there were symptoms of progressive disease. The main criteria for the analysis of response were progression-free survival (PFS) and overall response rate (ORR). The secondary criteria were overall survival (OS) and disease control rate (DCR). Additionally, the relationship of OS with sex, smoking history, and performance status (PS), as well as gefitinib toxicity were analyzed. Result: The ORR and DCR were 59.2% and 95.8%, respectively. The median PFS was 14.5 months and the median OS was 33 months. The longer OS was statistically significant in women and non-smokers, and the patients had a good PS. Adverse events occurred in 59.2% patients, but most of them were grade 1 and 2 events. Conclusion: This study conducted in Vietnam suggests the effectiveness of gefitinib as a first-line treatment option in patients with advanced NSCLC and positive EGFR mutations regardless of whether the patients have a good PS or not. In particular, targeted therapy with gefitinib improved the OS in women and non-smokers.
Comparison of itraconazole and griseofulvin for treatment of tinea corporis in Bac Ninh Dermatology Hospital
Authors: Van Bui Thi , Em Dang Van , Anh Nguyen Lan , Hang Do Thi Nguyet , Nhung Vu Hoang , Tuan Pham Van
Published: June 2022

Objective: To compare the efficacy of oral itraconazole with griseofulvin for tinea corporis treatment at Bac Ninh Dermatologic Hospital. Subject and method: A randomized, comparative and prospective study was conducted to compare 66 patients with tinea corporis at Bac Ninh Dermatologic Hospital. These patients were divided into 2 groups: Group 1: Consisted of 31 patients treated with oral Itraconazole (Kbat), and Group 2: Had 35 patients treated with oral Griseofulvin. Result: The result of tinea corporis treatment both clinically and microscopically was the same in two groups. The adverse effects were most seen in the group treated with oral Itraconazole, and the cost for treatment in the Itraconazole group was 7 times higher than in the Griseofulvin group. Conclusion: Oral griseofulvin for tinea corporis was effective and not too pricey.
Severe psoriatic arthritis patient being managed by anti IL-17A inhibition therapy in 108 Military Central Hospital
Authors: Hoa Vu Thi Thanh , Anh Bui Hoang , Son Nguyen Minh , Nghi Tran Hong
Published: June 2022

The article would like to introduce a psoriatic arthritis (PsA) patient in the Department of Rheumatology of 108 Military Central Hospital. This case of PsA had the secondary tuberculosis infection after Tumor necrotic factor inhibitor (TNFi) treatment, nevertheless the articular destruction caused by PsA still went on. The next management in these patients is always a controversy among the rheumatologists because the lack of international and national recommendation of management step-by-step. In addition, there were not many articles mentioning about this problem. After doctors-patient discussion, patient decided to be administered with Interleukin 17A inhibitor (IL-17Ai) (four doses secukinumab 300mg SC) plus methotrexate, then the disease remission (Minimal disease activity) was achieved without burden of tuberculosis. This success could contribute to the clinical experiences of biologic therapy in patients with severe side effects of TNFi treatment which becomes the more and more popular and causing many difficulties for clinicians.
Apnoeic oxygenation with high‐flow oxygen for tracheal resection and reconstruction
Authors: Ly Nguyen Minh , Hung Tong Xuan , Hai Ngo Vi , Dung Dang Trung , Trang Dinh Thi Thu , Tho Nguyen Truong , Truong Nguyen Quang , Khai Dam Van , Khanh Nguyen Quoc , Dinh Ngo Van
Published: June 2022

Objective: This study aimed to evaluate the effectiveness of high‐flow oxygen as the sole method of gas exchange in apnoeic conditions during anastomosis construction. Subject and method: Between April 2019 and August 2020, 16 patients with tracheal stenosis, ages ranging from 19 to 70, underwent tracheal resection and reconstruction. Patients received total anesthesia and neuromuscular blocking agents for the duration of their surgery. During the anastomosis phase using high flow oxygen of 35 - 40 l.min‐1 delivered across an open tracheal with an endotracheal tube (ETT) at the glottis in apnoeic conditions. Result: The mean (SD) apnoea time was 20.91 ± 2.53 mins. Mean (SD) time anastomosis was 22.9 ± 2.41 mins. The saturation of oxygen was stable during all procedures at 98-100%. One patient experienced an oxygen desaturation episode to a value between 88% and 90% lasting less than 2 mins. Arterial blood gas analysis showed that there was hypercapnia and acidosis acute respiratory with pH 7.25 ± 0.04; PaCO2 67.57 ± 14.71mmHg, and PaO2 167.12 ± 76.23mmHg after 10 mins of apnoea and pH was 7.17 ± 0.05; PaCO2 79.63 ± 13.39mmHg and PaO2 186.19 ±  60.14mmHg after 20 mins apnoea, respectively. However, after 15 mins of ventilation, the parameters are ultimately returned to normal. The blood pressure and heart rate are stable at times. All 16 patients were extubated early and safely at the end of the operation. There were no complications, such as bleeding, hemothorax, pneumothorax, or barotrauma. Conclusion: High-flow oxygen across an open tracheal under apnoeic conditions can provide a satisfactory gas exchange to allow tubeless anesthesia for tracheal resection and reconstruction. The surgical field is ultimately in spacious, optimal conditions for anastomosis.
Association of ESBL and CTX-M gene with the clinical outcome of patients suffer from bloodstream infections caused by Escherichia coli and Klebsiella pneumoniae
Authors: Son Trinh Van , Trung Ngo Tat , Manh Nguyen Dang , Song Le Huu
Published: June 2022

Objective: To evaluate the value of CTX-M on the clinical outcome of bloodstream infection (BSI) patients caused by E. coli and K. pneumoniae. Subject and method: A total of 165 BSI patients were treated at 108 Military Central Hospital from Oct. 2014 to May 2016, including 115 cases caused by E. coli and 50 cases caused by K. pneumoniae. All strains were identified and performed antibiotic susceptible test by Vitek II system (Bio-Merieux, USA). CTX-M gene encoding ESBL was screened using polymerase chain reaction method. Result: In total, the percentage of ESBLs producing strains was 47.3% and CTX-M was detected in 62.4% (103/165) all of strains. We observed that there was not significant difference with the clinical outcome between BSI patients caused by CTX-M positive strains (septic shock 22.3% and fatality 21.4%) and BSI patients caused by cephalosporin resistant strains (17.9% - 22.5% with shock and 17.9% - 22.5% with fatality). However, when we analyzed the subgroup of BSI patients caused by cephalosporin susceptible strains. The proportion of shock and fatality in groups with CTX-M positive were higher than that in group with CTX-M negative (21.6% - 33.3% vs 14.6% - 19.2% with shock and 18.9% - 26.7% vs 10.4 - 15.4% with fatality). Additionally, the length of hospital stay in groups with CTX-M positive were significant longer than that in group with CTX-M negative. Conclusion: Our data showed a high prevalence of ESBL producing strains causing BSI patients, and also high prevalence of CTX-M positive strains. Moreover, in BSIs caused by cephalosporin susceptible strains, the clinical outcome of group with CTX-M positive were worse than that of group with CTX-M negative.
Evaluation of the effectiveness of the procedures of creating autologous stem cell product derived bone marrow fluid for treatment of ischemic stroke patients
Authors: Khai Ly Tuan , Ngoc Nguyen Hoang , Tuyen Nguyen Van , Truong Ho Xuan
Published: June 2022

Objective: To implement the process and to evaluate the effectiveness of extracting necessary stem cell components and removing unnecessary cell components. Subject and method: 57 patients (40 male and 17 female patients) with subacute ischemic stroke (7th day - 30th day) including 40 male and 17 female patients. 240ml of bone marrow taken from iliac crests of each patient had diluted in 60ml of heparin solution for anticoagulation. Then, we continued to implement concentration process to reduce the volume in order to remove erythrocytes, granulocyte cells, concentrate process on mononucleus cells (including stem cells). Result: After the process, the components of stem cell package collected after concentrating were as follows: The bone marrow-derived stem cell product had the mean concentration of nucleus cells which was 29.07 ± 18.29G/l, the mean concentration of CD34+ stem cells was 549.79 ± 378.55 cells/pl; the rate of CD34+ in total nuclear cells was 1.87 ± 0.94% and the viable CD34+ rate was 94.65 ± 4.62%. The retain ratio of CD34+ stem cells was 57.64 ± 32.35% equivalent to the mean total number of CD34+ stem cells which was 10.99 ± 7.37 × 106 cells. Removal ratio of granulocyte and erythrocyte was 90.09 ± 10.82% and 99.59 ± 0.23%, respectively. Conclusion: The process of creating autologous bone marrow-derived stem cell product for the treatment of patients with subacute ischemic stroke has been effectively performed in term of collecting useful stem cells and eliminating unnecessary cell components.
Efficacy assessment of shoulder rehabilitation with Contrex MJ robot in patients with periarthritis humeroscapularis
Authors: Thuy Bui Thi Hong , Luu Nguyen Trong , Hang Pham Thi Le , Hung Nguyen Manh
Published: June 2022

Objective: To assess the efficacy of shoulder rehabilitation program incorporating exercise with Contrex MJ robot in patients with periarthritis humeroscapularis. Subject and method: We evaluated a total of 62 patients (n = 62) suffered from the non-specific shoulder pain and frozen shoulder, who were admitted to our medical institution between June of 2016 and May of 2017. In these patients, the efficacy outcome measures were improved in Visual Analogue Scale, Range of motion. Result and conclusion: There were improvements of periarthritis humeroscapularis from five to fifteen day treatment period (p=0.04), there were not any cases with complications in our subjects.
An overview of applying virtual reality intervention to improve functional outcomes for post-stroke patients in rehabilitation
Authors: Duyen Pham Thi
Published: June 2022

Post-stroke patients may have to experience a wide range of impairments or deficits such as movement dysfunction or cognitive impairments that require early rehabilitation management to get better recovery. The rapid development in technology facilitates for many aspects in medicine and rehabilitation. In recent years, virtual reality intervention has been a novel therapy improving functional outcomes among post-stroke patients (Lee, Park, & Park, 2019). Specifically, virtual reality technology has created a life-like environment to stimulate physical activities that may encourage stroke survivors to take part in activities willingly through interaction in virtual environment which is quite similar with the real world (Kizony, Levin, Hughey, Perez, & Fung, 2010). This overview is going to analyse the effectiveness of virtual reality intervention in improving functional outcomes for post-stroke patients and give some recommendations in clinical practice.
The role of qualified elastography ultrasound in assessment of malignant thyroid nodules
Authors: Hanh Tuong Thi Hong , Hoang Nguyen Huy
Published: June 2022

Objective: To study the stiffness characteristics of benign and malignant thyroid nodules on elastography ultrasound and the evaluation of elastography ultrasound in the diagnosis of thyroid cancer. Subject and method: This study included 535 patients with 557 thyroid nodules confirmed by histopathology, from September 2019 to August 2020. All patients were evaluated by elastography ultrasound, using US machine (GE Logiq S8, US) and ROI Qualified Elastography, the class the score of stiffness according to the Rago T.‘s score (2007). Result: Of 557 thyroid nodules, 7 nodules with stiffness score 1 (1.3%), 78 nodules with stiffness of score 2 (14.0%), 197 nodules with stiffness of score 3 (35.4%), 170 nodules with stiffness of score 4 (40.3%), 105 nodules with stiffness of score 5 (18.8%). In the group’s low stiffness (score 1, 2), the rate of benign thyroid nodules was higher than that of malignant’s group with p<0.05. In contrast, in the group’s high stiffness (score 4, 5), the rate of malignant thyroid nodules was higher than benign’s group with p<0.05. In the group’s medium stiffness (score 3), the difference between groups of benign and malignant thyroid nodules was not statistically significant (p>0.05). Diagnosis of a malignant thyroid nodules by elastography ultrasound had a sensitivity of 57.4% and a specificity of 91.3%. Conclusion: The stiffness of the malignant thyroid nodules was higher than that of thyroid nodules by elastography ultrasound; The diagnostic value of the malignant thyroid nodules had a sensitivity of 57.3% and a specificity of 91.3%.
Study on clinical, subclinical characteristics, serum immunoglobulins concentration during and after of acute exacerbation of chronic obstructive pulmonary disease
Authors: Công Nguyễn Hải , Thắng Tạ Bá , Lực Nguyễn Huy
Published: June 2022

Objective: To describe the clinical, subclinical characteristics and serum immunoglobulin concentrations during and after of acute exacerbations (AE) of chronic obstructive pulmonary disease (COPD). Subject and method: A prospective observational study. 127 cases were enrolled: 30 healthy persons in control group and 97 patients with AE of COPD, being treated at 103 Military Hospital from October 2015 to August 2017. Result: Severe and very severe dyspnea accounted for the highest proportion, average mMRC score of 3.2 ± 0.7. Life-threatening AE accounted for 43.3%. Increased number of leukocytes was 54.6%. Disorders of blood glucose and kidney function were common, increasing serum PCT levels by 54.6%, and CRP by 68%. Increased pCO2 was 47.4% and respiratory acidosis was 33% in arterial blood gas in AE. The serum concentration of IgG, IgG1 during and after of AE were lower than the control group. The serum concentration of IgA in COPD patients were higher than control group (p<0.001). Conclusion: Severe clinical symptoms accounted for a high proportion in AE and life-threatening AE accounted for 43.3%. Leukocytosis, increased serum PCT and CRP levels were common in AE. Serum IgG concentrations during and after of AE were significantly lower than in the control group.
Giá trị chẩn đoán và tiên lượng mức độ suy gan của nồng độ interleukin-6 huyết tương ở bệnh nhân xơ gan
Authors: Tiến Đào Đức , Việt Nguyễn Đình , Huy Dương Quang
Published: June 2022

Mục tiêu: Xác định giá trị của interleukin-6 (IL-6) huyết tương trong chẩn đoán và tiên lượng mức độ suy gan ở bệnh nhân xơ gan. Đối tượng và phương pháp: Tiến cứu, mô tả cắt ngang 60 bệnh nhân xơ gan và 30 người khỏe mạnh được xét nghiệm IL-6 máu lúc đói theo phương pháp hấp thụ miễn dịch gắn enzyme tại Khoa Nội tiêu hóa - Bệnh viện Quân y 103. Kết quả: Trung vị nồng độ IL-6 huyết tương ở bệnh nhân xơ gan là 7,79pg/mL, cao hơn có ý nghĩa so với chỉ số tương ứng ở nhóm chứng 6,68pg/mL, p<0,001. Nồng độ IL-6 huyết thanh có giá trị chẩn đoán xơ gan với AUC = 0,85 (95% CI: 0,76 - 0,93). Nồng độ IL-6 huyết tương có tương quan thuận mức độ vừa với điểm Child-Pugh (r = 0,34, p=0,009) và có giá trị dự báo mức độ suy gan Child-Pugh B/C với AUC = 0,69 (95% CI: 0,54 - 0,83), tại điểm cắt 7,46pg/mL có độ nhạy 91,7%; độ đặc hiệu 45,8%. Kết luận: IL-6 huyết tương có giá trị chẩn đoán xơ gan và tiên lượng mức độ suy gan theo thang điểm Child-Pugh.
Nghiên cứu biểu hiện của ISG20 ở bệnh nhân ung thư biểu mô gan có liên quan đến HBV
Authors: Dũng Phạm Văn , Phương Nguyễn Viết , Duật Nguyễn Quang , Thanh Nguyễn Thị , Thảo Trần Thị Phương , Phượng Đào Thị , Uyển Nguyễn Ngọc , Tổng Hoàng Văn
Published: June 2022

Mục tiêu: Interferon stimulated gene 20 (ISG20) là một trong những ISG có tác dụng ức chế quá trình nhân lên của một số virus như Hepatitis B virus (HBV) và có mối liên quan đến một số bệnh lý ác tính trong đó có ung thư biểu mô tế bào gan (UTBG). Đối tượng và phương pháp: 41 bệnh nhân chẩn đoán UTBG được khai thác lâm sàng, cận lâm sàng và được điều trị bằng phẫu thuật sau đó lấy tổ chức khối u và tổ chức mô cạnh u RNA toàn phần được tách từ các mẫu mô sau đó chuyển thành cDNA và đánh giá mức độ biểu hiện ISG20 mRNA bằng phương pháp qRT-PCR. So sánh mức độ biểu hiện của ISG20 ở khối u và tổ chức mô cạnh u và đánh giá mối liên quan với một số chỉ số cận lâm sàng ở nhóm nghiên cứu. Kết quả: Biểu hiện ISG20 mRNA không khác nhau ở giữa trung tâm khối u so với tổ chức mô lành cạnh u (p=0,22), biểu hiện ISG20 mRNA khối u có mối tương quan chặt chẽ với chỉ số bilirubin toàn phần và không có mối liên quan đến nồng độ AFP với p>0,05. Kết luận: Không có sự khác biệt giữa biểu hiện ISG20 ở mô khối u và mô cạnh khối u. Biểu hiện ISG20 có liên quan đến một số biểu hiện lâm sàng của bệnh nhân UTBG.
So sánh hiệu quả điều trị hạt cơm bằng phương pháp xịt nitơ lỏng kết hợp bôi dung dịch castellani so với kết hợp bôi eosin 2% vào đáy tổn thương
Authors: Hào Nguyễn Trọng , Tuấn Trương Lê Anh , Nhi Phạm Thị Uyển , Ngọc Lê Thị Minh
Published: June 2022

Mục tiêu: So sánh hiệu quả điều trị hạt cơm bằng phương pháp xịt nitơ lỏng kết hợp bôi dung dịch castellani so với kết hợp bôi eosin 2% vào đáy tổn thương tại Bệnh viện Da Liễu Thành phố Hồ Chí Minh. Đối tượng và phương pháp: Nghiên cứu trên 52 bệnh nhân hạt cơm đến khám tại Bệnh viện Da Liễu Thành phố Hồ Chí Minh trong thời gian nghiên cứu. Trong đó, 26 bệnh nhân được điều trị bằng xịt nitơ lỏng kết hợp với bôi castellani (nhóm 1) và 26 bệnh nhân được xịt nitơ lỏng kết hợp với bôi eosin 2% (nhóm 2). Kết quả: Mẫu nghiên cứu có tỉ lệ nam - nữ tương đương nhau và đa số (51,90%) thuộc độ tuổi 11 - 30. Ở cả 2 nhóm nghiên cứu, số lượng hạt cơm trung bình là 2 với phần lớn trường hợp có thời gian mắc bệnh 3 - 6 tháng, 84,60% là bệnh nhân mới, chưa điều trị. Không có sự khác biệt có ý nghĩa thống kê về tình trạng phồng rộp thương tổn sau xịt nitơ lỏng giữa 2 nhóm nghiên cứu tại tuần 2, tuần 4 và tuần 8. Tuy nhiên, nhóm bệnh nhân có dùng castellani bôi ở đáy thương tổn cho tỉ lệ bong mài tổn thương cao hơn và nhanh hơn so với nhóm bôi eosin 2%. Ngoài ra, nhóm bệnh nhân dùng castellani có thời gian lành thương nhanh hơn. Kết luận: Nhóm bệnh nhân có kết hợp bôi castellani ở đáy thương tổn sau xịt nitơ lỏng cho tỉ lệ bong tổn thương cao hơn và nhanh hơn so với nhóm bôi eosin 2% vào đáy tổn thương và thời gian lành thương nhanh hơn.
Một số yếu tố liên quan và đặc điểm lâm sàng trong bệnh nấm da thân tại Bệnh viện Da liễu Bắc Ninh
Authors: Tuấn Phạm Văn , Vân Bùi Thị , Nhung Vũ Hoàng , Hằng Đỗ Thị Nguyệt
Published: June 2022

Mục tiêu: Nghiên cứu một số yếu tố liên quan và lâm sàng bệnh nấm da tại Bệnh viện Da liễu Bắc Ninh. Đối tượng và phương pháp: 66 bệnh nhân nấm da thân điều trị tại Bệnh viện Da liễu Bắc Ninh từ tháng 09/2018 đến tháng 09/2019, phương pháp tiến cứu, mô tả cắt ngang. Kết quả và kết luận: 39,4% bệnh nhân dưới 30 tuổi; tỷ lệ nam/nữ là 2,2/1; vị trí thương tổn thường gặp nhất là ở mông (45,5%); 59,1% bệnh nhân có diện tích thương tổn trên 100cm2; 100,0% bệnh nhân có đỏ da và ngứa.
Hiệu quả và an toàn của laser Q-switched Nd:YAG 532nm và laser xung dài alexandrite 755nm trong điều trị đốm nâu
Authors: Hào Nguyễn Trọng , Tú Trần Nguyên Ánh , Phượng Trần Kim , Quân Nguyễn Duy
Published: June 2022

Mục tiêu: Đánh giá hiệu quả và tính an toàn, cũng như so sánh hai phương pháp điều trị đốm nâu bằng laser Q-switched Nd:YAG 532nm và laser xung dài alexandrite 755nm. Đối tượng và phương pháp: Nghiên cứu loạt ca được thực hiện trên 32 bệnh nhân, trong đó có 3 bệnh nhân được điều trị bằng cả hai máy cho 2 đốm nâu khác nhau, như vậy chúng tôi ghi nhận 35 trường hợp, trong đó có 22 đốm nâu được điều trị bằng laser QS Nd:YAG 532nm và 13 đốm nâu được điều trị bằng laser alexandrite 755nm. Các bệnh nhân được điều trị từ 1 đến 3 lần, đánh giá các chỉ số Von-Luschan và Mexameter để xác định hiệu quả, cũng như ghi nhận lại các tác dụng phụ để đánh giá mức độ an toàn ở tuần thứ 4, 8 và 12. Kết quả: Nghiên cứu của chúng tôi nhận thấy, đối với QS Nd:YAG 532nm, độ giảm chỉ số Von-Luschan và Mexameter có ý nghĩa thống kê qua các lần điều trị (p=0,0001 và p=0,0005). Với Alexandrite 755nm, độ giảm chỉ số Von-Luschan có ý nghĩa thống kê qua các lần điều trị (p=0,0004). Tác dụng phụ chỉ ghi nhận một trường hợp tăng sắc tố sau viêm ở QS Nd:YAG 532nm (7,7%) và 2 trường hợp (một tăng sắc tố sau viêm và một đỏ da sau laser) ở alexandrite 755nm (9,1%). Kết quả so sánh cho thấy, mức độ đau ở bệnh nhân sử dụng laser QS Nd:YAG 532nm thấp hơn có ý nghĩa thống kê so với bệnh nhân sử dụng laser alexandrite 755nm. Đánh giá chỉ số Von-Luschan có sự khác biệt có ý nghĩa thống kê giữa QS Nd:YAG 532nm và alexandrite 755nm. Kết luận: Laser QS Nd:YAG 532nm và laser xung dài Alexandrite 755nm cho hiệu quả và tính an toàn cao trong điều trị đốm nâu. Bệnh nhân sử dụng laser QS Nd: YAG cảm giác ít đau hơn so với bệnh nhân sử dụng laser alexandrite 755nm. Laser QS Nd: YAG cho hiệu quả điều trị ưu thế hơn trong lần đầu điều trị, tuy nhiên, về lâu dài, hai loại laser này đều cho hiệu quả điều trị như nhau.
Đánh giá hiệu quả điều trị nha chu không phẫu thuật có/không có hỗ trọ laser diode lên kiểm soát đường huyết ở bệnh nhân đái tháo đường týp 2: Nghiên cứu thử nghiệm lâm sàng có đối chứng
Authors: Minh Nguyễn Văn , Tuấn Tạ Anh , Hùng Hoàng Tử
Published: June 2022

Mục tiêu: Đánh giá hiệu quả điều trị nha chu không phẫu thuật có/ không có hỗ trợ laser diode 810nm lên kiểm soát đường huyết ở bệnh nhân đái tháo đường týp 2. Đối tượng và phương pháp: 60 bệnh nhân đái tháo đường có viêm nha chu mạn tính được chọn ngẫu nhiên. Nhóm can thiệp (n = 30), được cạo cao-làm láng mặt gốc răng và chiếu hỗ trợ laser diode 810nm (SRP + DL). Nhóm chứng (n = 30), cạo cao-làm láng mặt gốc răng đơn thuần (SRP). Các chỉ số lâm sàng gồm: Chỉ số nướu (GI), chỉ số mảng bám răng (PI), độ sâu túi nha chu (PD), mất bám dính lâm sàng (CAL) và kết quả HbA1c được ghi nhận ở các thời điểm trước can thiệp và sau 3 tháng. Kết quả: Có sự cải thiện về lâm sàng, đường huyết ở cả hai nhóm sau 3 tháng điều trị. Các chỉ số lâm sàng nha chu (PI, GI, PD, CAL) giảm có ý nghĩa thống kê sau 3 tháng (p<0,001) ở cả hai nhóm. Chỉ số đường huyết ở nhóm SRP + DL giảm có ý nghĩa thống kê (p=0,04) sau 3 tháng điều trị nha chu và giảm có ý nghĩa thống kê (p=0,03) so với nhóm SRP đơn thuần. Kết luận: Điều trị nha chu có hỗ trợ laser diode giúp kiểm soát đường huyết (HbA1c) tốt hơn có ý nghĩa so với nhóm điều trị nha chu đơn thuần.
Đánh giá hiệu quả của siêu âm định vị trong phẫu thuật cắt bỏ u nội sọ
Authors: Yên Nguyễn Trọng , Dũng Trần Quang , Lân Đặng Hoài , Tiệp Vũ Quang
Published: June 2022

Mục tiêu: Đánh giá hiệu quả của siêu âm tích hợp với hệ thống định vị trong phẫu thuật cắt bỏ u nội sọ. Đối tượng và phương pháp: 32 bệnh nhân u nội sọ được phẫu thuật cắt bỏ u có sử dụng siêu âm trong mổ tích hợp với hệ thống định vị tại Khoa Ngoại thần kinh, Bệnh viện Trung ương Quân đội 108 trong thời gian từ tháng 1/2020 đến tháng 5/2020. Sau khi quá trình cắt bỏ khối u được hoàn thành, các đường viền vùng cắt bỏ của tất cả các bệnh nhân được kiểm tra bằng siêu âm với một đầu dò 13MHz. Bất kỳ vùng cản âm nào có độ dày > 5mm tính từ vùng phẫu thuật đến bề mặt não được xác định là còn tồn dư u. Một vòng cản âm liên tục có độ dày < 5mm được coi là bình thường. Các kết quả được đánh giá trong mối tương quan với cộng hưởng từ có tiêm thuốc đối quang từ chụp trong vòng 48 giờ sau phẫu thuật. Kết quả: Giá trị Kappa cho mối tương quan giữa hai phương pháp là 0,72. Có 4 trường hợp trên cộng hưởng từ xác định còn sót u mặc dù âm tính trên siêu âm. Sự phù não lan tỏa, các chất cầm máu (Surgicel) dọc theo các bờ của vùng mổ (2 ca u tế bào thần kinh đệm đa hình thái - GBM, 1 ca ung thư biểu mô di căn, 1 ca Anaplastic astrocytoma) có thể là lý do cho việc không phát hiện được phần còn sót lại. Kết luận: Siêu âm trong mổ tích hợp với hệ thóng định vị là một công cụ hiệu quả để tối đa hóa mức độ cắt bỏ khối u nội sọ.
Thông báo trường hợp hội chứng nội soi mức độ nặng sau nội soi cắt tuyến tiền liệt qua đường niệu đạo
Authors: Hùng Tống Xuân , Lý Nguyễn Minh , Trang Đinh Thị Thu , Khải Hoàng Khắc , Hường Nguyễn Thị Thúy , Định Ngô Văn
Published: June 2022

Hội chứng nội soi là tác dụng không mong muốn trong phẫu thuật nội soi cắt tuyến tiền liệt, tỷ lệ từ 0,78% - 1,4%. Nguyên nhân do hấp thu dịch rửa nội soi nhược trương, không chất điện giải vào lòng mạch gây quá tải tuần hoàn, giảm nồng độ natri máu, giảm áp lực thẩm thấu huyết thanh dẫn đến phù não, hôn mê, phù phổi cấp, trụy tim mạch, có thể gây tử vong. Chúng tôi báo cáo trường hợp lâm sàng hội chứng nội soi mức độ nặng với biểu hiện lâm sàng phù phổi, suy hô hấp cấp; xét nghiệm nồng độ Na+ máu 112,6mmol/l, áp lực thẩm thấu huyết thanh 234mOsmol/kg, pH: 7,23, pO2: 45mmHg, pCO2: 44mmHg. Xử trí: Thở CPAP-PSV Pro qua mặt nạ mặt với PEEP +5cmH2O, hỗ trợ áp lực 8cmH2O, FiO2 70% - 100%; tiêm tĩnh mạch 20mg furosemid, truyền 150ml NaCl 3%; 100ml natribicarbonat 8,4%. Bệnh nhân phục hồi tốt. Kết luận: Hội chứng nội soi mức độ nặng là tác dụng không mong muốn của phẫu thuật nội soi cắt tuyến tiền liệt có thể gây nguy hiểm đến tính mạng của bệnh nhân nên cần được theo dõi, phát hiện và xử trí kịp thời, phù hợp.
Báo cáo một trường hợp phẫu thuật nội soi sau phúc mạc bóc mạch bạch huyết trong điều trị bệnh đái dưỡng chấp
Authors: Dũng Trần Đức , Linh Trần Văn , Phúc Nguyễn Văn , Nguyên Lê Đình , Thịnh Nguyễn Thị
Published: June 2022

Đái dưỡng chấp là sự đi qua bất thường của dưỡng chấp trong nước tiểu. Bệnh thường gặp ở người lớn và có thể ở cả 2 bên thận, nguyên nhân phổ biến nhất là do nhiễm ký sinh trùng Wuchereria bancrofti. Các nguyên nhân khác bao gồm chấn thương, khối u, lao và dị tật bẩm sinh. Báo cáo này mô tả việc điều trị thành công 1 bệnh nhân bị đái dưỡng chấp bằng phẫu thuật nội soi ổ bụng qua đường sau phúc mạc. Trường hợp lâm sàng: Bệnh nhân nữ 61 tuổi phải chịu đựng lâu dài với các triệu chứng của tiểu dưỡng chấp 1 bên. Điều trị bảo tồn thất bại đã dẫn đến việc sử dụng kĩ thuật nội soi ổ bụng để cắt mạch bạch huyết thận. Thời gian mổ 60 phút, lượng máu mất 20ml. Không có biến chứng trong và sau mổ. Kết luận: Phẫu thuật nội soi ổ bụng qua đường sau phúc mạc cắt mạch bạch huyết cuống thận để điều trị tiểu dưỡng chấp là 1 kĩ thuật an toàn và hiệu quả với sự xâm lấn tối thiểu, ít đau, thời gian hậu phẫu ngắn, nhanh hồi phục