bluuebunny/crossref_metadata_2025 huggingface dataset:
Preferential expression of T-cell receptor V beta-chains in atopic eczema.
Authors: Neuber K , Löliger C , Köhler I , Ring J.
Published: June 2023

Chronic skin colonization with Staphylococcus aureus is a characteristic feature of atopic eczema, and about 60% of S. aureus strains isolated from the skin of patients with atopic eczema secrete enterotoxins. T-cell stimulation by staphylococcal enterotoxins is restricted to the V beta-chain of the T-cell receptor. Therefore, the expression of different V beta-chains (V beta 3, 5 a,b,c, 6, 8, 12) on peripheral blood T-cells (CD4+) from patients with atopic eczema was measured by flowcytometry before and after stimulation with staphylococcal enterotoxin B. Lymphocytes from healthy donors served as controls. Additionally, the expression of V beta-chains in normal skin and in lesional skin of patients with atopic eczema was determined by immunofluorescence histology. In atopic eczema, higher numbers of CD4+ T-cells expressed V beta 3, V beta 8 and V beta 12 compared to the control group. No correlation between S. aureus enterotoxin B-stimulated V beta-expression and HLA-haplotypes was found. In lesional skin of patients with atopic eczema most of the infiltrating T-cells were V beta 3+, whereas in normal skin only very few T-cell receptor-expressing cells were detected. To evaluate the significance of these T-cell clones for allergic inflammation, T-cells from patients with atopic eczema and normal donors were stimulated with monoclonal antibodies against V beta 3, 5(c) and 8. Afterwards, the proliferative response of lymphocytes as well as IL-5 and IFN gamma synthesis were measured. T-cells from patients with atopic eczema showed a significantly higher proliferation and IL-5 secretion than normal donors after stimulation with monoclonal antibodies against V beta 3 and V beta 8. In contrast, the monoclonal antibodies directed to V beta 5(c) induced a markedly elevated proliferation and IFN gamma production of normal lymphocytes compared to patients with atopic eczema. Our results suggest a preferential expression of certain V beta-subgroups during inflammation in atopic eczema
Psoriasis treatment: bathing in a thermal lagoon combined with UVB, versus UVB treatment only.
Authors: Olafsson JH , Sigurgeirsson B , Pálsdóttir R.
Published: June 2023

We have compared bathing in a thermal lagoon in Iceland, combined with UVB treatment, to UVB treatment only in an open comparative study. Twenty-three psoriasis patients bathed 3 times daily and were treated with UVB 5 times a week for 4 weeks. The control group was only treated with UVB 5 times a week for 4 weeks. Psoriasis Area and Severity Index (PSAI) was used to estimate the severity of the disease. The mean PASI score in the bathing group decreased from 20.8 to 2.8 (p < 0.01). In the control UVB group, the PASI score decreased from 16. 7 to 6.9. The percentage difference between the groups was significant after 1, 2, 2 and 4 weeks. Bathing in the lagoon combined with UVB was found to be a very effective treatment and better than UVB treatment in our control group.
Integrin molecules: a clue to the non-metastasizing behaviour of basal cell carcinomas?
Authors: Baum HP , Schmid T , Reichrath J.
Published: June 2023

Does the integrin profile of basal cell carcinomas explain their non-metastasizing behaviour? Immunohistochemical Investigation of nodular (n = 31) and superficial (n = 17) tumours yielded a strong expression of alpha 2, alpha 3, alpha 6, beta 1, and beta 3 subunits and a weak expression of alpha 4 subunits by the epithelial tumour component. alpha 5 subunits were focally detected in superficial basal cell carcinomas but not in the nodular type. Tumour cells were nearly devoid of alpha v subunits. The integrin profile of basal cell carcinomas does not differ essentially from that of metastasizing tumour varieties and cannot be regarded as a major reason for the non-metastasizing phenotype of basal cell carcinomas.
Acute urticaria: clinical aspects and therapeutic responsiveness.
Authors: Zuberbier T , Iffländer J , Semmler C , Henz BM.
Published: June 2023

Although acute urticaria is common, its eliciting factors, clinical course and therapeutic responsiveness have not been intensively investigated. We have therefore prospectively studied all patients with acute urticaria attending the department of dermatology (n = 72) and a rural dermatology office (n = 37) during the course of 1 year. After a standardized history and physical examination, patients were randomized into treatment with either loratadine (10 mg/day for 3 days) or prednisolene (50 mg/day for 3 days). All patients were followed up until complete remission. Most patients suffered from moderate (42%) to severe (40%) disease. Possible eliciting factors were identified in less than 50% of the cases. Associated upper respiratory tract infections were found most commonly (39.5%), followed by possibly eliciting drugs, mostly analgesics (9.2%) and suspected food intolerance (0.9%). The course of the disease was self-limited in all cases, the longest episode lasting for 3 weeks. Both treatment regimens were effective in controlling whealing, but in corticosteroid-treated patients, symptoms ceased earlier, with complete remission occurring within 3 days of treatment in 93.8%, compared to 65.9% of patients treated with loratadine (p < 0.001). Acute urticaria is thus frequently idiopathic and only rarely associated with IgE-mediated events. It is, however, largely self-limited, with prompt response to symptomatic treatment.
Macular posterior pigmentary incontinence: its relation to macular amyloidosis and notalgia paresthetica.
Authors: Westermark P , Ridderström E , Vahlquist A.
Published: June 2023

Patients with clinical features of dorsal macular amyloidosis but without subepidermal amyloid deposits were followed for 2-11 years. The clinical appearance was fairly stable during this period of time, with little tendency of healing. Only 2 of the patients developed typical macular amyloidosis during the follow-up. It is concluded that a condition strongly resembling macular amyloidosis but without amyloid is an entity, and the designation "macular posterior pigmentary incontinence" is proposed. The relationship between macular posterior pigmentary incontinence and the two conditions macular amyloidosis and notalgia paresthetica is discussed.
Climatotherapy at the Dead Sea stimulates vitamin D3 metabolism.
Authors: Kragballe K , Avrach WW , Politi Y , Landau M , Brenner S.
Published: June 2023

No Abstract available.
Allopurinol therapy in post-kala-azar dermal leishmaniasis.
Authors: Ramesh V.
Published: June 2023

No Abstract available.
On T-cell recognition of nickel as a hapten.
Authors: Emtestam L , Olerup O.
Published: June 2023

T-cells recognize antigens as peptides associated with self-molecules encoded by genes of the HLA region. In patients with contact allergy to nickel, T-cells that are specific for non-peptide haptens have been described. Previously, we have isolated HLA class II-restricted nickel-specific T-cell clones from patients with nickel sensitivity. In this paper, data on the fine specificity of a nickel-specific HLA-DR4-restricted clone have been reevaluated. Genomic tissue typing employing polymerase chain reaction and sequence-specific primers were used. Nickel was presented to the T-cell clone by all three subtypes of HLA-DR4 included in our panel. Two different DRB4*0404-positive cells presented nickel, whereas only 3 of the 7 DRB1*0401-positive and one of the 3 DRB1*0408-positive cells restimulated the T-cell clone. These findings are compatible with the notion that nickel interacts with endogenous peptides in the antigen-presenting groove of the HLA molecule, thereby changing these peptides' antigenicity rather than their ability to bind to the HLA molecule. Variations of the endogenous peptide in the antigen-presenting groove as well as differences of the HLA molecules give the DR4 specificity of the nickel-specific clone MCE2.
Immunohistochemical studies of proinflammatory cytokines and their receptors in hair follicles of normal human skin.
Authors: Ahmed AA , Nordlind K , Schultzberg M , Brakenhoff J , Bristulf J , Novick D , Svenson SB , Azizi M , Lidén S.
Published: June 2023

Immunoreactivity to interleukin-1 alpha, interleukin-1 beta, interleukin-6 and tumour necrosis factor-alpha and their receptors, as well as the endogenous interleukin-1 receptor antagonist, was investigated in hair follicles in paraffin-embedded normal human skin. Interleukin-1 beta- and tumour necrosis factor-alpha-like immunoreactivities were found in the inner root sheath layer of hair follicles, at the suprapapillary level. Interleukin-1 receptor-like immunoreactivity was also found in this layer, while there was a variable immunoreactivity to the interleukin-1 receptor antagonist. In the outer root sheath there was a weak to moderate staining for the four cytokines, in addition to intense staining for their receptors and a weak staining for the antagonist. The fibrous root sheath had a moderate immunoreactivity for interleukin-1 alpha and interleukin-6. The distribution patterns suggest that these cytokines, particularly interleukin-1 beta and tumour necrosis factor-alpha, may have a protective role in hair formation, while all the investigated proinflammatory cytokines may have a role in the differentiation process.
Focal dermal hypoplasia (Goltz syndrome): a decreased accumulation of hyaluronic acid in three-dimensional culture.
Authors: Sato M , Ishikawa O , Yokoyama Y , Kondo A , Miyachi Y.
Published: June 2023

We report a 28-year-old female with focal dermal hypoplasia, (Goltz syndrome). We compared the growth kinetics and the production of type I collagen and glycosaminoglycans by fibroblasts from affected and unaffected skin. Fibroblasts were grown in conventional medium supplemented with ascorbic acid 2-phosphate, which makes fibroblasts from a tissue-like structure in vitro. The population doubling time of fibroblasts in affected skin was slightly shorter than that of unaffected skin. There was no difference in the levels of the carboxyterminal propeptide of type I procollagen liberated into the media between affected skin and unaffected skin. However, the cell layer of affected skin fibroblasts revealed a decreased amount of hyaluronic acid-derived disaccharide unit (delta Di-HA). The abnormal metabolism of glycosaminoglycan in the affected dermis might be involved in the development of skin changes in focal dermal hypoplasia.
Appearance of Sézary-like atypical lymphocytes in the regressing lesions of juvenile xanthogranuloma. Its role in the spontaneous regression.
Authors: Bang D , Cho NJ , Lee IJ , Ahn SK.
Published: June 2023

A case of juvenile xanthogranuloma of the skin was sequentially biopsied for 10 months. In the electron microscopic examination of the regressing lesions, we observed that cells with highly indented nuclei, Sézary-like cells, were in close apposition to vacuolated degenerating histiocytes in many foci. In immunohistochemical stain, the number of UCHL-1+ cells were increased in regressing lesions compared with early lesions. We speculate that these Sézary-like atypical lymphocytes may be closely related to the spontaneous regression of juvenile xanthogranuloma.
Sun-related behaviour in individuals with dysplastic naevus syndrome.
Authors: Brandberg Y , Jonell R , Broberg M , Sjödén PO , Rosdahl I.
Published: June 2023

In Sweden, individuals with dysplastic naevus syndrome are regularly screened and informed about self-examination and sun-protection at special clinics. This study describes sun-related behaviour in this group. A total of 54/65 consecutive patients with dysplastic naevus syndrome (28 women and 26 men) completed diary recordings of sun-related behaviour during 1 month in 1994. A majority (81%) reported sunbathing with the intention to get a tan, mean number of occasions 9.2, range 1-24 occasions, during the month of recordings. Out of these, 61% reported sunburns, some of them repeatedly up to 7 times. Sunbathing occurred mainly in bathing suits during midday in sunny weather, with a mean duration of 2.5 h per occasion. Such a hazardous behaviour in the sun in a melanoma high risk group is alarming. New models for intervention to support a more sun protective life style in this group of patient have to be elaborated.
Differential expression of desmosomal glycoproteins in keratoacanthoma and squamous cell carcinoma of the skin: an immunohistochemical aid to diagnosis.
Authors: Krunic AL , Garrod DR , Smith NP , Orchard GS , Cvijetic OB.
Published: June 2023

The distinction between keratoacanthoma and squamous cell carcinoma is a common dermatopathological dilemma. Although the mainstay of the diagnosis is still clinico-pathological correlation, many dermatopathologists now include keratoacanthomas in the spectrum of squamous cell carcinomas. Recent reports, however, have pointed out that keratoacanthoma is "deficient squamous cell carcinoma" since it loses the expression of bcl-2 antigen, consistent with initiation of apoptosis, i.e. its involution. Electron microscope studies performed in keratoacanthomas and squamous cell carcinomas also revealed significantly reduced desmosomes in squamous cell carcinoma, but not in keratoacanthoma. A series of 38 keratoacanthomas and 62 squamous cell carcinomas of the skin (28 well-differentiated, 21 moderately differentiated and 13 poorly differentiated) were stained immunohistochemically with the monoclonal antibody 32-2B to desmosomal glycoproteins desmoglein 1 and desmoglein 3. Thirty-five keratoacanthomas showed extensive pericellular desmoglein expression. Three keratoacanthomas and 20 squamous cell carcinomas (19 well-differentiated, 1 moderately differentiated) showed focal staining, and in 11 squamous cell carcinomas (2 moderately differentiated, 9 poorly differentiated) the staining was negative. The remaining 31 squamous cell carcinomas (9 well differentiated, 18 moderately differentiated, 4 poorly differentiated) showed juxtanuclear staining. None of the squamous cell carcinomas exhibited the extensive pericellular pattern found in keratoacanthomas. Assessment of staining intensity, by 3 independent examiners, revealed a strong negative correlation between desmoglein expression and degree of dysplasia in the squamous cell carcinomas (p < 0.01). This antibody therefore clearly distinguishes these tumours and may be of value in the differential diagnosis of keratoacanthoma and squamous cell carcinomas in routine histopathology.
Transient hyperpigmentation after calcipotriol ointment and PUVA therapy in psoriatic patients.
Authors: Vázqvez-López F , Pérez-Oliva N.
Published: June 2023

No abstract available.
Multiple keratoacanthomas, giant keratoacanthoma and keratoacanthoma centrifugum marginatum: development in a single patient and treatment with oral isotretinoin.
Authors: Schaller M , Korting HC , Wolff H , Schirren CG , Burgdorf W.
Published: June 2023

A 78-year-old man is described, who over 18 years developed three different types of keratoacanthoma: multiple keratoacanthomas, keratoacanthoma centrifugum marginatum and giant keratoacanthoma. Histological examination of the different neoplasms showed similar changes, all typical of a keratoacanthoma. In situ hybridisation revealed no human papilloma virus in the tumours. Complete examination showed no associated internal malignancy. After repeated surgical treatment oral isotretinoin treatment was administered (1 mg/kg per day). This treatment produced clearing of existing keratoacanthomas and, during a period of 2 months, further keratoacanthoma formation was completely suppressed. Treatment was stopped after 3 months by the patient because of side-effects. Numerous keratoacanthomas developed during the following 6 weeks.
Inguinal mycetoma.
Authors: Dogra D , Ramam M , Banerjee U.
Published: June 2023

No abstract available.
Cyclosporin A down-regulates the LTA4 hydrolase level in human keratinocyte cultures.
Authors: Iversen L , Svendsen M , Kragballe K.
Published: June 2023

Leukotriene A4 hydrolase is a key enzyme in the biosynthesis of leukotriene B4, a potent pro-inflammatory compound. The purpose of this study was to determine the capacity of antiinflammatory and anti-proliferative compounds to regulate the levels and activity of leukotriene A4 hydrolase in cultured human keratinocytes. The content of leukotriene A4 hydrolase was determined by Western blot analysis, and the activity of leukotriene A4 hydrolase was expressed as the leukotriene B4 formation after incubation of keratinocyte cultures with leukotriene A4. Leukotriene B4 was measured by revered-phase high performance liquid chromatography. Preincubation for 10 min of the cultured keratinocytes with the leukotriene A4 hydrolase inhibitor RP 64699 (0.1-10 microM) caused a significant dose-dependent inhibition of leukotriene B4 formation (IC50 = 0.7 microM). Cyclosporin A (0.1 micrograms/ml and 1.0 micrograms/ml) had no direct effect on leukotriene A4 hydrolase activity, but after incubation for 72 h there was a decrease in the mean leukotriene B4 formation per culture dish (35% and 48%, respectively). The decreased leukotriene B4 formation was caused mainly by a decrease in the mean leukotriene A4 hydrolase content per mg protein (30.1% at 0.1 micrograms/ml cyclosporin A and 40.0% at 1.0 micrograms/ml cyclosporin A), although keratinocyte proliferation was also slightly decreased. Incubations with 1.25-dihydroxyvitamin D3 (10(-7)-10(-10) M), all-trans retinoic acid (10(-6)-10(-10) M), eicosartienoic acid (10(-6)-10(-8) M), dexamethasone (10(-5)-10(-7) M), interferon-gamma (10 and 100 units/ml) or methotrexate (0.1-10 micrograms/ml) had no effect on either the leukotriene B4 formation or the amount of leukotriene A4 hydrolase in keratinocyte cultures. These results show that cyclosporin A, in contrast to other anti-inflammatory and anti-proliferative compounds, inhibits the level of leukotriene A4 hydrolase in keratinocyte cultures. Since similar cyclosporin A concentrations are obtained during treatment of psoriasis with cyclosporin A, the effect on leukotriene A4 hydrolase may play a role in the anti-inflammatory action of cyclosporin A.
Association of psychic stress with clinical severity and symptoms of psoriatic patients.
Authors: Harvima RJ , Viinamäki H , Harvima IT , Naukkarinen A , Savolainen L , Aalto ML , Horsmanheimo M.
Published: June 2023

The association of stress with psoriatic skin and joint symptoms was studied in 38 patients with psoriasis by dividing the patients into low-stress and high-stress groups based on their answers to four questionnaires (General health questionnaire, Somatization questionnaire, Depression questionnaire, and Life change questionnaire), measuring minor psychiatric disorder, psychosomatic reactivity, depression and life changes, respectively. Compared to the low-stress group (n = 21), the patients in the high-stress group (n = 17) had more severe skin and joint symptoms and a higher score, which in established psoriatic General severity score that was calculated by judging Psoriasis Area and Severity Index, activity of psoriasis and the presence of joint symptoms. All the four questionnaires showed higher morbidity frequency and higher score points. Actively spreading psoriasis was significantly associated with stressful life events for men but not for women. However, in the low-stress group, men had experienced significantly fewer stressful events than women. Psoriasis Area and Severity Index showed strong correlation with the Somatization score, but no differences between men and women. The General severity score correlated with the Somatization score, and the higher the General severity score (score > or = 6) the higher were all the four questionnaire scores. Also, patients having joint symptoms had higher scores in all of the four psychic questionnaires than patients without joint symptoms. By the chi-test, female patients with joint symptoms showed a significant correlation with the high General health questionnaire. The presence of joint symptoms showed a tendency for correlation in women with high depression level and in men with high somatization level. This study suggests that psychic stress is associated with exacerbation of psoriasis, and more attention to mental well-being should be paid at least in the case of those psoriatic patients seeking actively for medical care.
Nail surgery: an assessment of indications and outcome.
Authors: De Berker DA , Dahl MG , Comaish JS , Lawrence CM.
Published: June 2023

To examine the merits of nail surgery, we studied the surgical investigation, treatment and the outcome of 78 consecutive patients with nail pathology in the context of their complaint. A diagnosis was reached in 74/78 patients. Thirty-six out of seventy-eight (46%) of patients had tumours, 17/78 (22%) had a dermatosis, 21/78 (27%) had infection or trauma and 4/78 (5%) remained undiagnosed. The presenting complaint was treated with substantial or complete resolution in 66/78 (87%) patients. Ninety-seven per cent (35/36) of those with tumours were cured, including all 5/36 with malignant and dysplastic tumours. Post-operative splitting of the nail was seen in only one patient due to secondary infection of a longitudinal nail unit biopsy. Information from this study demonstrates the diagnostic and therapeutic value of nail surgery within dermatology.
Cutaneous manifestations of Takayasu arteritis.
Authors: Werfel T , Kuipers JG , Zeidler H , Kapp A , Kiehl P.
Published: June 2023

No abstract available
Familial Kaposi's sarcoma: case reports and review of the literature.
Authors: Cottoni E , Masia IM , Masala MV , Mulargia M , Contu L.
Published: June 2023

We report 4 new families with Kaposi's sarcoma, occurring in 2 members of the same family (2 pairs of brothers, uncle and nephew and father and son) in a series of 160 patients with Kaposi's sarcoma. In addition, HLA typing was also carried out for 6 of the 8 patients. A detailed review of the literature is also presented. The total number of familial cases of Kaposi's sarcoma is low (only 30 cases are described)
Brittle and sparse hair with normal cystine content caused by methionine deficiency?
Authors: Goerz G , Behrens W , Megahed M , Kuester W , Fohles J , Tsambaos D , Nikiforidis G , Balas C.
Published: June 2023

The unusual case of an 8-year-old girl with a hair disorder is presented, characterized by brittle, short and sparse hair. On polarizing microscopy the latter reveals a "tiger tail" pattern, whereas severe cuticular defects are detected on scanning electron microscopy. The patient's hair has a normal cystine content but is completely devoid of methionine and reveals distinct changes of its visoelastic parameters. It is presently unknown whether the lack of methionine may be implicated in the pathogenesis of this hair disorder, which to the best of our knowledge has not been previously described.
Morphologic features and clinical significance of skin involvement in patients with AIDS-related cryptococcosis.
Authors: Manfredi R , Mazzoni A , Nanetti A , Mastroianni A , Coronado O , Chiodo F.
Published: June 2023

Eight out of 30 consecutive patients with AIDS and cryptococcal meningoencephalitis (26,7%) presented cutaneous involvement, in the form of papulo-nodular lesions in 3 patients, molluscum contagiosum-like lesions in 3 patients, and pustular-ulcerative lesions in 2 patients. Skin localization represented an untoward prognostic sign, and in 3 out of 8 patients the lesions were diagnosed 2 to 6 weeks before the onset of systemic and neurologic signs and symptoms of the disease. A systematical examination of all suspected cutaneous lesions in subjects with advanced HIV disease may lead to an earlier diagnosis and treatment of disseminated cryptococcosis.
Ofuji's papuloerythroderma: report of a new case responding to PUVA.
Authors: Depaire F , Dereure O , Guilhou JJ.
Published: June 2023

No abstract available.
Use of XTT-assay to assess the cytotoxicity of different surfactants and metal salts in human keratinocytes (HaCaT). A feasible method for in vitro testing of skin irritants.
Authors: Brosin A , Wolf V , Mattheus A , Heise H.
Published: June 2023

Because of the increasing need of reliable skin irritation tests and in order to reduce the number of animal experiments, in vitro alternatives have to be developed. We studied four surfactants and five metal salts for their cytotoxic potency in HaCaT cells, a spontaneously immortalized human keratinocyte line. The endpoint used to assess cellular viability was metabolization of the tetrazolium salt XTT (2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino) carbonyl]-2H-tetrazolium hydroxide). The tested substances revealed a significant rank order of their cytotoxicity at an exposure time of 24 h. It was 1) benzalkonium chloride, 2) sodium lauryl sulphate, and 3) Tween 20 (polyoxyethylene sorbitanmonolaurate) and Tween 80 (polyoxyethylene sorbitanmonooleate), for the surfactants
Effects of dermabrasion on acne scarring. A review and a study of 25 cases.
Authors: Aronsson A , Eriksson T , Jacobsson S , Salemark L.
Published: June 2023

Acne scarring is often treated with dermabrasion and results are evaluated using photographs. We have studied 25 patients before treatment and up to 1 year after dermabrasion for acne scars. Comparisons of results evaluated in different ways show that dermabrasion works best for superficial scars, results for more severe forms of scarring being less predictable.
Pseudoxanthoma elasticum-like papillary dermal elastolysis. A report of two cases and review of the literature.
Authors: Vargas-Díez E , Peñas PF , Fraga J , Aragües M , García-Díez A.
Published: June 2023

Pseudoxanthoma elasticum-like papillary dermal elastolysis is a peculiar idiopathic elastolytic disorder with cutaneous lesions clinically resembling pseudoxanthoma elasticum with partial or total band-like elastolysis of the papillary dermis histopathologically, and without systemic complications. We here report 2 new cases and review the clinicopathological features of patients with this diagnosis in the literature. The possible pathogenesis of this recently described entity is discussed.
Histopathological and bacteriological findings in prurigo nodularis.
Authors: Mattila JO , Vornanen M , Katila ML.
Published: June 2023

Prurigo nodularis is a chronic disease with unknown aetiology. Biopsy specimens of 43 patients with prurigo nodularis were taken for histopathological and mycobacteriological analyses. By conventional histopathology, 25 (58%) samples, and by immunostaining for S100 protein, 31 (72%) samples had changes relevant to prurigo nodularis. Twelve (28%) of the samples were positive for acid fast bacilli in tissue staining by Ziehl-Neelsen technique, including 4 of the 6 samples also positive for mycobacteria in cultivation. The results verified the usefulness of S100 staining in detection of neural hyperplasia in dermal nerves, a feature regarded as diagnostic for prurigo nodularis. They also indicated that atypical mycobacteria may be a contributing factor in prurigo nodularis.
Melanosis naeviformis of Becker and scoliosis: a coincidence?
Authors: Maessen-Visch MB , Hulsmans RF , Hulsmans FJ , Neumann HA.
Published: June 2023

Melanosis naeviformis of Becker (MNB) can be associated with hypoplasia of soft tissue or extremities, spina bifida and scoliosis of the vertebral column. We have investigated 50 patients (42 men, 8 women) with MNB radiologically. Scoliosis was diagnosed in 13 patients (26%). The curves of scoliosis varied from 11 degrees to 17 degrees. Physical examination revealed no gross asymmetries of the trunk, extremities or breasts. No correlation was seen between the age of patients and the scoliotic curve. In one family the father and oldest son had MNB with scoliosis and the other son and daughter had MNB without scoliosis. Since only mild scoliosis is found in patients with MNB, X-ray examination of the vertebral column has no therapeutic consequences.
The effect of topical capsaicin on substance P immunoreactivity: a clinical trial and immunohistochemical analysis.
Authors: Munn SE , Burrows NP , Abadia-Molina F , Springall DR , Polak JM , Russell Jones
Published: June 2023

No abstract available.
Lentigo maligna treated with ruby laser.
Authors: Thissen M , Westerhof W.
Published: June 2023

No abstract available.
Ultrastructure of murine dermis following topical application of the vitamin D3 analogue KH-1060.
Authors: Kobayasi T.
Published: June 2023

The aim of this study, was to observe the effects of KH-1060, a new vitamin D3 analogue, on the dermis of hairless mice by electron microscopy. KH-1060 (0.2 micrograms/ml in isopropanol) or KH-1060 following betamethasone 17-valerate (2 mg/ml in isopropanol) was applied topically to the backs of hairless mice for 4 weeks. KH-1060 increased the number of dermal fibroblasts, the cytoplasm of which was dominated by secretory components. Mast cells contained normal mature granules and degranulated after disintegration. No extrusion of non-disintegrated granules was seen. Collagen fibrils were thickened and increased in number
Formation of active IL-1 beta from pro-IL-1 beta catalyzed by stratum corneum chymotryptic enzyme in vitro.
Authors: Nylander-Lundqvist E , Egelrud T.
Published: June 2023

Interleukin 1 beta (IL-1 beta) is produced as a biologically inactive 31 kD precursor, which is converted to the active 18 kD form by proteolytic processing. Keratinocytes express IL-1 beta but not the active form of the specific IL-1 beta converting enzyme (ICE). We have recently presented evidence that IL-1 beta activation in human epidermis occurs via an alternative mechanism involving hitherto unknown proteases. We asked whether stratum corneum chymotryptic enzyme (SCCE), which is a serine protease specifically expressed in keratinizing squamous epithelia, can act as an IL-1 beta activator in vitro. Recombinant human pro-IL-1 beta was incubated with recombinant SCCE, and the reaction products were characterized as regards molecular size and ability to induce expression of E-Selectin in human umbilical cord endothelial cells. SCCE caused degradation of pro-IL-1 beta and the accumulation of a component with electrophoretic mobility slightly lower than recombination mature IL-1 beta. Whereas incubation mixtures with pro-IL-1 beta which had been incubated in the absence of SCCE, or with SCCE, which had been incubated in the absence of pro-Il-1 beta, did not induce expression above baseline levels of E-Selectin, pro-Il1 beta which had been incubated with SCCE induced a significant increase in E-Selectin expression. This effect could be abolished by neutralizing antibodies to IL-1 beta, but not by antibodies to IL-1 alpha. In addition to IL-1 beta activation, SCCE also prepared to be able to catalyze a further degradation of IL-1 beta, leading to a loss of biological activity. We conclude that SCCE is a potential candidate for being responsible for IL-1 beta activation in human epidermis.
Porokeratosis of Mibelli. Overview and review of the literature.
Authors: Schamroth JM , Zlotogorski A , Gilead L.
Published: June 2023

Porokeratosis of Mibelli is an uncommon dermatosis, which may be associated with immunosuppression and may undergo malignant transformation. Due to the wide range of clinical presentations, numerous classifications have evolved, resulting in some confusion. This article examines the classification and presentation of porokeratosis and, in particular, reviews the association with immunosuppression.
Subacute and chronic prurigo effectively treated with recombination interferon-gamma: implications for participation of Th2 cells in the pathogenesis of prurigo.
Authors: Tokura Y , Yagi H , Hanaoka K , Ito T , Towyama K , Sachi Y , Tanaka M , Sakamoto T , Sekizuka T , Furukawa F , Takigawa M.
Published: June 2023

Subacute and chronic prurigo is notoriously resistant to usual therapies. Four of five patients with a subacute or chronic form of prurigo responded well to daily intravenous injections of recombinant interferon-gamma (rIFN-gamma) (0.25-2 x 10(6) Japan Reference Unit (JRU
Anti-230 kDa circulating IgE in bullous pemphigoid: relationship with disease activity.
Authors: Cozzani E , Micalizzi C , Parodi A , Rebora A.
Published: June 2023

No abstract available
Long-term follow-up of toe-nail onychomycosis treated with terbinafine.
Authors: Brandrup F , Larsen PO.
Published: June 2023

No abstract available
Higher herpes zoster infection frequency in right-handed patients and more frequent appearance in the left body side of females.
Authors: Ertunç V , Dane S , Karakuzu A , Deniz O.
Published: June 2023

No abstract available
Minocycline induces an increase in the number of excreting pilosebaceous follicles in acne vulgaris. A randomised study.
Authors: Bodokh I , Jacomet Y , Lacour JP , Ortonne JP.
Published: June 2023

The effects of treatment with minocycline 100 mg per day on sebaceous excretion in acne vulgaris using lipometry and Sebutape were studied in 45 patients in an open study as well as in a randomised placebo-controlled study. In both studies a subclinical increase in sebaceous excretion was noted from the 28th day of treatment. This effect continued for 1 month after the end of treatment. The increase in sebaceous excretion was concomitant with an increase in the number of excreting pilosebaceous follicles. Minocycline may cause the follicles to become unblocked by acting on the factors responsible for ostial hyperkeratosis, in addition to an antibacterial effect on retentional acne lesions.
Dominant dystrophic epidermolysis bullosa albopapuloidea Pasini -- ultrastructural observations of albopapuloid lesions and a type VII collagen DNA polymorphism study of a family.
Authors: Nomura K , Umeki K , Sawamura D , Hashimoto I.
Published: June 2023

We describe a case of dominant dystrophic epidermolysis bullosa (DDEB) albopapuloidea Pasini. The patient was a 42-year-old female with albopapuloid lesions on her back, which had developed when she was 17. Histological examination of the albopapuloid lesions showed prominent proliferation of immature collagen bundles and deposition of amorphous material, which stained positively with Alcian blue. Electron microscopy of her albopapuloid lesions revealed marked nodular proliferation of collagen bundles from just beneath the basal lamina to the mid-dermis. In the light of these findings, we speculate that such albopapuloid lesions result from a reactive accumulation of collagen and glycosaminoglycan occurring on the EB skin. A PvuII and AluI polymorphism study of type VII collagen DNA from the patient's family suggests that the candidate gene for DDEB in her pedigree could be the type VII collagen gene.
Urethritis associated with isotretinoin therapy.
Authors: Edwards S , Sonnex C.
Published: June 2023

No abstract available
Colocalization of somatostatin- and HLA-DR-like immunoreactivity in dendritic cells of psoriatic skin.
Authors: Talme T , Schultzberg M , Sundqvist KG , Marcusson JA.
Published: June 2023

This study presents an immunohistochemical characterization of somatostatin-positive dendritic cells in psoriatic lesions. Somatostatin is a neuropeptide with inhibitory action on several neuropeptides and hormones, but also with immunomodulating properties, and has been used in several studies as treatment for psoriasis. The number of somatostatin-positive dendritic cells was found to be larger in psoriatic lesions than in normal skin of psoriasis patients and healthy controls. Colocalization of somatostatin and HLA-DR immunoreactivity was demonstrated in a subgroup of dendritic cells of psoriatic skin, whereas double-labelled cells were not found in uninvolved skin. The somatostatin-positive cells in the epidermis and dermis did not co-express CD1a, CD35, CD45RB, CD45RO, CD68, factor XIIIa or S-100. On the basis of these findings, the somatostatin-positive cells seem to represent a specific population of dermal dendritic cells, distinct from Langerhans' cells and factor XIIIa-positive cells, which are found in elevated amounts in chronic plaque psoriasis.
Evaluation of PUVA bath phototoxicity.
Authors: Neumann NJ , Kerscher M , Ruzicka T , Lehmann P.
Published: June 2023

Administration of 8-methoxypsoralen in a dilute bath water solution is an effective therapeutic alternative to its systemic application, avoiding systemic side effects. Although PUVA bath photochemotherapy is now widely used, standardized guidelines are not yet available. Therefore, the aim of our study was to determine the optimal time interval between 8-methoxypsoralen bath and UVA irradiation and the persistence of photosensitivity after PUVA bath treatment. In volunteers the highest photosensitivity was observed following UVA irradiation immediately after PUVA bath. A sharp increase of the minimal phototoxic dose could be demonstrated after only 1 h, indicating a rapid loss of 8-methoxypsoralen activity. Irradiation 2 h after 8-methoxypsoralen bath failed to induce any PUVA erythema. This indicates that the optimal time for UVA irradiation is immediately after the 8-methoxypsoralen bath. In contrast to systemic PUVA therapy, 2 h after PUVA bath therapy, the remaining phototoxicity is minimal, so that no stringent restrictions of the patient's behaviour are needed.
A new patient with idiopathic tripe palms.
Authors: Siragusa M , Batolo D , Schepis C.
Published: June 2023

No Abstract available
A double-blind comparison of levels of terbinafine and itraconazole in plasma, skin, sebum, hair and nails during and after oral medication.
Authors: Faergemann J , Zehender H , Boukhabza A , Smith SG , Jones TC.
Published: June 2023

No Abstract available
Coevolution and Adaptation of Viral Infections, Susceptible Populations, Evolution of Disease and Variant Creation Related to SARS-CoV-2
Authors: Caldararo Niccolo
Published: June 2023

Covid-19 has created a major health challenge as a pandemic and demonstrates the threats that human populations face with increased population numbers and density of living situations. Pathogen adaptations to the human immune system are a treat to social complexity and evolution. Present theory argues that human social complexity has advanced in population density due to epidemiologic transition. Globalization and increase human needs for resources with increased density may be reaching limits of the potential for further transitions. The spread of the disease has resulted from mutations making the virus more easily transmitted. Analysis of the viral genome also shows substantial recombination among viral species, quasi-species and variants since an evolutionary event some 5,000 years ago that created several coronavirus groups. Rapid evolution due to recombination and purifying selection of the viral genome, pose a substantial difficulty in producing vaccines and methods of preventing transmission without onerous social distancing and other practices. Typical aspects of the natural history of pathogen infection in mammalian populations that limit the spread, duration and severity of disease (immunity, etc.) appear to be undermined by these features of viral mutation and gene exchange. Breakthrough infections, reinfection after disease and viral escape of vaccines due to evolution of mutations, indicate the possibility of endemic coronavirus in human populations.
Socio-Economic Structure & Sustainable Development of Indigenous Society: A Study on the Munda Community
Authors: Kumar Sarker Bipul
Published: June 2023

There are 50 indigenous or minority ethnic groups scattered across different regions of Bangladesh, of which the Mandas are a community. The Munda community has been living in the areas adjacent to the Sundarbans of Khulna and Satkhira districts for hundreds of years. Originally, their forefathers were the ones who cut down the forest and made the land suitable for cultivation without caring about the roar of the tiger and the snake. The ancestors of the Munda’s played a major role in cutting down the forests in the area surrounding the present Sundarbans and making them suitable for human settlement. The number of Munda’s scattered in the Sundarbans and its surrounding areas is decreasing day by day due to various types of adverse environment. On the other hand, the Munda’s own culture is also under threat due to the influence of Bengali culture. The main aim of this research is how to develop sustainable development of the Munda community from their current socioeconomic structure in view of the current condition of the Munda community. The study is mainly quantitative in nature. Koira and Dumuria upazila of Khulna district and Shyamnagar, Debhata and Tala upazila of Satkhira district were selected through convenient sampling technique for the purpose of collecting primary data, because a large part of Munda community lives in these areas. Structured questionnaire was used to collect data from 250 respondents from five preselected areas. The respondents were selected using simple random sampling technique. Data was analyzed in terms of statistical indicators of frequency and percentage. The results of the study show that social indicators, Economic indicators and Cultural factors are very weak among the Munda community. Among the social indicators, Munda women and men have very little interest in following hygiene rules (Sanitation, Birth Control). Economic indicators show Income Source, Jobs Opportunity Munda community is facing many challenges recently. Many educated boys and girls of the Munda community spend their days in agony due to lack of suitable jobs which has a negative impact on everyone in the community. Cultural factor shows that the Munda community, which is plagued by poverty, can celebrate its cultural events in a grand manner, so that other communities or ethnic groups do not get any idea about their culture. This research will be of great help to those who work with the indigenous communities of Bangladesh, especially the various ministries of the government, NGOs, policy makers, government and private research organizations will be benefited.
Social Movements in Brazil: From the 1970’s to the Present Day the Influence of Social Movements and their Relationship with Democracy and Party Organizations in the Last Fifty Years
Authors: Braga de Carvalho Roger Ricardo
Published: June 2023

This article discusses the relationship between social movements and democracy in the last fifty years in Brazil. This research aims to analyze the influence of demonstrations and street protests, which took place between 1970 and 2020, on the Brazilian democratic process and party institutions. The analysis starts from the social struggles against the dictatorship and Catholic Church through the CEBs (Base Ecclesiastical Communities) at the end of the 1970s. The struggles for redemocratization and for popular participation in the 1980s are also analyzed. The networked social movements and the new social movements, according to Alain Touraine, are also objects of this research. It is observed that social movements influence not only institutions and the democratic process but also individual and collective identities that share their ideologies, which expressively altered the political game and institutions’ functioning.
Dwelling the Violences in Today’s World: A Critical Sketches on Tim Ingold’s Poetics of Dwelling
Authors: Romeu Vivian
Published: June 2023

This text seeks to briefly reflect on [1] poetics of dwelling, which is relevant as a theory in the social sciences due to the dynamic nature with which it describes existence as an active living, that is, as a living co-creator of reality, of what happens. For this reason, the author’s commitment to make dwelling as a participatory and relational experience between the subject and his environment that constitutes a fundamental perspective to understand the existence of social life as a constituted historical-concrete process through action.
Innovative Ways of Treating Diabetic Peripheral Neuropathy in the United States: A Narrative Review
Authors: Joseph Saju
Published: June 2023

Diabetes is a prevalent disease in the United States with severe, life changing and costly complications. One such complication is peripheral neuropathy which manifests itself as a chronic pain and decreased sensation. The exact mechanism of its development is not completely understood; however, it has been determined that a prolonged state of hyperglycemia leads to oxidative and nitrosative stress to the nerve fibers, edema, inflammation, demyelination and ischemia. The current approach to treatment of diabetic neuropathy focuses on three main aspects: glycemic control, lifestyle modifications and management of neuropathic pain. Because the management of neuropathic pain has varied success among different patients and does not address the underlying pathophysiology of nerve damage, novel technologies and treatment techniques are being developed. Among those are the hyperbaric oxygen therapy and angiogenesis stimulating agents. Animal studies produced impressive results, such as enhanced angiogenesis, decreased inflammation and nerve regeneration. Human trials are also being conducted, and those technologies might be the next big step in the treatment of patients with diabetic peripheral neuropathy.
Evaluation of Sperm Selection Technique Using Hyaluronic Acid Binding During ICSI; A Randomized Controlled Trial
Authors: Hassan Eman Anwar
Published: June 2023

Objective: To compare between Hyaluronan binding system for sperm selection for ICSI procedures (PICSI) and conventional morphology sperm selection. In vitro sperm selection for ICSI is important as it has a direct influence on the paternal contribution of preimplantation embryogenesis. Various laboratory tests were developed to assess the functions of the spermatozoa. Among them, only the tests for sperm DNA fragmentation, hyperactivation of the spermatozoa and the hyaluronan-binding ability are simple and fast. Study Design: A randomized controlled trial where three-hundred cases with male infertility were divided into 3 equal groups according to semen abnormality (oligo, astheno and teratozoospermia) then each group was randomly divided into 2 equal subgroups one underwent PICSI and the other underwent conventional ICSI. The outcomes were fertilization,high quality embryos and clinical pregnancy rate. Results: A significant difference was found in favor of PICSI as regards both high-quality embryos and clinical pregnancy rate in all 3 groups. A significant difference was also found in fertilization rate in favor of PICSI group in both oligozoospermia and teratozoospermia groups but not in asthenozoospermia group. Conclusion: PICSI technique provides better high-quality embryos, fertilization, and clinical pregnancy rates in cases with male factor infertility; however, further studies are needed to define specific criteria for performing PICSI taking into consideration both the expenses and time of the technique.
Membrane Modification with Polydopamine to Improve Performances — A Mini Review
Authors: Muchtar Syawaliah , Yusuf Mukramah , Mulyati Sri , Syamsuddin Yanna , Fathanah Umi , Takagi Ryosuke
Published: June 2023

This paper provides an overview of some studies and investigations regarding the utilization of polydopamine as an additive in membrane fabrication. Polydopamine is widely used due to its high hydrophilicity and adhesive properties. The addition of polydopamine in to the membrane system mostly attributed to the improvement of membrane performance in terms of permeation, antifouling, and antibiofouling.