bluuebunny/crossref_metadata_2025 huggingface dataset:
Eros und Polemos
Authors: von Bülow Ulrich
Published: October 2021

«Wenn das bekannt wird, ist mein Ruf als Genie dahin» – so oder so ähnlich äußerte sich Peter Sloterdijk, als wir in seinem Keller hinter Weinvorräten unter Bergen von Büchern zahlreiche verstaubte Ordner und Mappen voller Exzerpte fanden. Sie stammen aus seiner Studienzeit um 1970 und zeugen von einem ungewöhnlichen Lesehunger und einer beeindruckenden Arbeitsdisziplin. Um sich den Inhalt des Gelesenen noch gründlicher anzueignen, setzte er sich nach der Lektüre eines Buches an den Schreibtisch und formulierte in sauberer Handschrift oder mithilfe der Schreibmaschine mit Zitaten gespickte Zusammenfassungen.
HIGH ENTROPY ALLOWS A BETTER AFFINITY BETWEEN METAL IONS AND ACTIVATED CARBON FIBRES
Authors: Choi Sang Sun , Lee Soon Hong , Yun Kyung Jae , Jin Young Min , Lee Joon Hyuk
Published: October 2021

Recent numerical approaches to extracting metal species using carbonaceous materials have de facto stimulated an interest in the field of microextraction, but theoretical observations inspired by randomness changes have been elusive. In this contribution, we present the degree of randomness using Cu (II) and Pb (II). Here, activated carbon fibres were employed as the skeleton adsorbent, providing scientific insights via the aqueous phase. Coupled isotherms of Langmuir and Freundlich were represented to unravel the aforementioned thermodynamics. Findings revealed that the Langmuir isotherm best described the equilibrium state and the trend was in accordance with the energy computation. The maximum microextraction performance was 84.75 mg/g and 102.04 mg/g for Cu (II) and Pb (II), respectively. Under all circumstances, there was a high randomness change as the microextraction performance increased.
PREPARATION OF ATO NANOPOWDERS WITH Co-PRECIPITATION AND THEIR LASER-REFLECTION PROPERTIES
Authors: Zhang Jing
Published: October 2021

Antimony tin oxide (ATO) nanoparticles were prepared using co-precipitation with tin chloride and antimony chloride as the main raw materials. X-ray diffraction (XRD), field-emission scanning electron microscopy (FESEM) and ultraviolet-visible spectrophotometry were used to characterize the crystal structure, morphology and laser reflectivity. The effects of the pH value, co-precipitation reaction temperature, calcination temperature and calcination time on the laser reflectivity of ATO nanoparticles were studied. The results show that, compared with the undoped SnO2 powder, the reflectivity of a Sb-doped ATO powder at a laser wavelength of 1.06 µm is significantly reduced, and with an increase in the Sb doping, the reflectivity of the ATO powder at 1.06 µm first decreases and then increases. When the Sb/Sn molar ratio is 2/10, the reflectivity decreases to the lowest point, which is caused by the high concentration of Sb5+. ATO powders (Sb/Sn = 2/10) prepared at a titration-end-point pH of 2, co-precipitation temperature of 70 °C, calcination temperature of 800 °C and calcination time of 6 h have the lowest laser reflectivity at the laser wavelength of 1.06 µm, which is less than 0.02 %.
Analysis of the feasibility of the use of rainwater: A case study for standard school infrastructures
Authors: Batista Karmem Julya Miron , Nunes de Melo Allan Jayson , Duarte Marques Soares Maria Carolina , Da Silva Simone Rosa
Published: October 2021

With the growth in water demand worldwide, cities are experiencing increasing difficulties to guarantee the public supply of drinking water. Therefore, the search for alternatives that replace the available sources needs to be disseminated. An alternative to reduce the demand for drinking water is to use the Rainwater harvesting system. This work analyzes the feasibility of implementing a system for capturing, storing, and distributing rainwater for non-drinking purposes in three standard projects of the National Fund for the Development of Education in three locations in the state of Pernambuco: Recife, Caruaru, and Petrolina. To achieve this objective, local rainfall data, the catchment area used and the demand for non-drinking water in the building were analyzed. Then, sizing calculations of the storage reservoir were performed by different methods. The time for return on investment was considered satisfactory for all types located in Recife and for the 1-room type in Caruaru and Petrolina, considering the benefit from the system in the long term. Therefore, the typologies of 6 and 12 rooms in Caruaru and Petrolina were excluded since they had a return time of more than 24 years. The advantages are not only financial, but also environmental, cultural, and educational.
EVALUATION OF PELVIC VENOUS DILATATION WITH COMPUTED TOMOGRAPHY IN PATIENTS WITH CELIAC DISEASE
Authors: DÜNDAR İlyas , GOYA Cemil , TÜRKO Ensar , ÖZKAÇMAZ Sercan , ÖZGÖKÇE Mesut , DURMAZ Fatma , AYYILDIZ Veysel  Atilla
Published: October 2021

Objective

Celiac disease (CD) is characterized by an immune

response in genetically gluten-sensitive individuals

resulting in inflammatory damage of the small

intestine. The radiological identification of pelvic

venous dilatation (PVD) is important as it can

contribute to the diagnosis of different spectrums of

pelvic and systemic diseases. In our study, we aimed

to determine the prevalence of PVD in CD patients

and to present our findings with the literature.

Materials and Methods

This retrospective observational study was approved

by the institutional review board in our institution. All

patients were patients diagnosed with CD by clinical

evaluation, serological data, and intestinal biopsy,

and who underwent CT between October 2011

and March 2020 in our medical center. CD patients

(n=149) and control group (n=250) who had contrastenhanced

CT were evaluated for PVD. In all patients,

PVD prevalence was examined in the patient and the

control group. The diameter of the pelvic veins was

measured and noted. Complaints of the patients were

noted from the hospital records.

Results

Among a total of 149 histopathologically proven patient

groups, there were 93 female and 56 male patients

with a mean age of 35.11±13.03 and 36.23±15.06

years, respectively. Among a total of 250 control

groups; there were 145 females and 105 males with

a mean age of 38.65±15.38 and 37.25±13.56 years,

respectively. PVD prevalence in the female and

male were 60.22% (n=56) and 41.07% (n=23) in CD

patients, respectively. 46.75% (n=36) CD patients

had abdominal pain and were correlated with PVD

(p
Un año de edición en Wikipedia: el caso del artículo «COVID-19» en diez lenguas
Authors: Tavares Lourenço Ricardo
Published: October 2021

Wikipedia, a big collective and collaborative work by its linguistic magnitude, has permitted to appreciate the writing and editing evolution of articles about emergent and changing themes as more and more data is revealed of different sources. After a year of official declaration of the World Health Organization of the COVID-19 pandemic existence, and the officialization of the disease´s name, it is an enough cycle to analyze how the editing of «COVID-19» article has been done since February 2020. Because of this, the available statistics in each version in the ten languages of the countries with more contagions were revised (English, German, French, Russian, Italian, Spanish, Chinese, Portuguese, Turkish and Hindi), and the number of editors involved on the volume and frequency of editions, rate of editing month to month were analyzed. In addition, the subtitles of the article in each studied language were compared to verify their order and hierarchy. The aim of this study is to consider no only the information’s density availability, but also to understand the weighing of some languages over others on popular science texts. We found out that the more number of editors, the longer and denser the articles are, and they prefer publishing information in global languages, regardless of the case number of contagions. Also, the editors agree on the order of the subtitles considering the target.
Prolegómenos a una teoría sobre la corrección de textos
Authors: Gómez Belart Nuria
Published: October 2021

Since the end of the 19th century, in Latin America, there has been a quite particular phenomenon in the publishing market. The different activities that were developed in this market began a slow process towards the professionalization of the tasks. Writers, translators, editors, journalists, and advertisers were no longer engaged in other activities in parallel, but instead invested all their energy in what, until now, was perceived as a hobby and not as a job that it deserved to be recognized as such. Thus, new professions arose along with spaces for formal education, and, progressively, scientific disciplines were born that provided the necessary academic support to each of them.In the particular case of proofreading and copyediting, professionalization was late and erratic. This is why, this article presents the contributions of those who promoted this transformation process during the first half of the 20th century: Manuel Benítez, Pelegrín Melús and Francisco Millá —two Spanish copyeditors who were taken as references in Argentina—, Eduardo Miragaya, José M. Rafols, Constancio C. Vigil, Raúl E. Lagomarsino and Carlos Pellegrini.Thus, taking as a starting point the emergence of the first institutions dedicated to the academic training of copyeditors, it reflects on the role of the copyeditor in the process of creating and publishing a text, the competencies that are required to carry out the task, the academicization process experienced by correction as a professional practice and the need to advance in the studies of Correctology, as an emerging linguistic discipline with a delimited object of study and a methodological base framed in Pragmatics and Text Linguistics.
Lenguaje claro en el siglo XXI: panorama general y propuesta de aplicación al proceso de traducción y corrección
Authors: Marazzato Sparano Romina
Published: October 2021

We present here an overview of plain language as an approach to writing and as a movement aligned with the right to understand as a civil right, and explore its role in informative texts, with particular interest in its application to translation and editing. We start from a functional and multifaceted conceptualization of the writing, translation and editing processes, reflected in ISO and ASTM standards. First, we present the definition of plain language developed within the International Plain Language Federation (IPLF) and adopted as a starting point for the development of ISO Standard 24495 on plain language (still underway). We also offer a historical overview of the milestones of plain language as a movement started in the 20th century—both internationally and in the Spanish-speaking world. Next, we present key principles of plain language as outlined by experts, including relevance, accessibility, intelligibility, and applicability; we suggest the principle of intelligibility be broken down into textuality and adequacy to enable a stepwise approach to text revisions. Finally, in considering the notion of text, we borrow from functional linguistics to contextualize the strategies presented to promote clarity. We focus on strategies to solve intelligibility problems, both in the writing and editing of monolingual text (source or target) and in translation, as these tasks specifically pertain to the work of translators and editors.
Analysis of Related Factors of Depression and Malnutrition in Elderly Hospitalized Patients v1
Authors: Ju Yanmin
Published: October 2021

SUMMARY: BACKGROUND:Depression and malnutrition are very common among elderly hospitalized patients and may lead to undesirable consequences. OBJECTIVE:To explore the correlation between depression and malnutrition through statistical methods to provide a theoretical basis for preventing the occurrence of depression and malnutrition in elderly hospitalized patients so as to improve their quality of life. METHODS:This is a retrospective analysis of 179 elderly inpatients in the Cadre Ward Unit of the First Hospital of Jilin University. Relevant data of the participants required for the study were obtained from the electronic medical record system and comprehensive geriatric assessment (CGA) database of the First Hospital of Jilin University. The correlation between depression and malnutrition was determined using logistic regression analysis. RESULTS:The percentage of included elderly inpatients without depression was 64.8%（median age=78.4 ± 10.3 years）, while the percentage of patients with depression was 35.2%（median age of 81.8 ± 8.4 years） . The prevalence of depression among the participants in the study was 35.2%, and the highest prevalence of depression combined with malnutrition was 58.9%, followed by 42.4% prevalence of depression combined with risk of malnutrition. After controlling for other relevant factors, the Mini Nutritional Assessment(MNA)(P=0.008,OR=0.821), albumin (P=0.005,OR=0.834) and calf circumference (P=0.004,OR=0.790) were independently associated with depression. CONCLUSION: There is a correlation between depression and malnutrition, and MNA, albumin and calf circumference are independent protective factors for depression, respectively. KEYWORDS:depression;malnutrition;elderly
Capacidade preditiva dos componentes do lucro e incerteza política: evidências de países da América Latina
Authors: Passos Lineker Costa , Cavalcante Paulo Roberto
Published: October 2021

Objetivo: Examinar se a capacidade dos componentes fluxo de caixa e accruals atuais em predizer futuros fluxos de caixa é afetada em períodos de incerteza política.Método: Considerou-se o ano de eleições nacionais como proxy para incerteza política, ao passo que a equação de previsão de fluxos de caixa de um período à frente, estimada por Sys-GMM, foi utilizada para captar a capacidade preditiva dos componentes do lucro segundo períodos de incerteza política. Amostra: Constituída por 386 firmas (4.127 observações-ano) listadas nas bolsas da Argentina, do Brasil, do Chile e do México.
Resultados: A capacidade preditiva do componente fluxo de caixa atual sofreu influência negativa de períodos de incerteza política, ao passo que a capacidade do componente accruals não se mostrou afetada por aqueles períodos. Conclui-se que incerteza política afeta negativamente a capacidade preditiva dos componentes do lucro divulgado, contudo tal efeito se mostrou conclusivo apenas para o componente fluxo de caixa atual.
Contribuições: Apresentação da realidade do mercado de capitais de países emergentes se constitui na principal contribuição do estudo. Ademais, adiciona-se conhecimento à literatura relacionada à hipótese de incerteza política, lançando luz sobre o impacto desse evento na oferta e disponibilidade de informações úteis em mercado de capitais de países emergentes. Também se mostra relevante para agentes que realizam previsões sobre fluxos de caixa futuros das firmas.
Cultura Organizacional, Nível de Parceria da Controladoria e Sistemas de Avaliação de Desempenho
Authors: Bassi Marília , Tadeu Russo Paschoal , Oyadomari José Carlos Tiomatsu , Oyadomari José Carlos Tiomatsu , Antunes Maria Thereza
Published: October 2021

Objetivo: Compreender as associações existentes entre as diferentes intensidades de tipificações de cultura organizacional (CO), níveis de parceria exercidos pelo setor de controladoria (NPC) e a amplitude dos sistemas de avaliação de desempenho organizacional (ASADO).Método: Estudo descritivo, com abordagem quantitativa, por meio de uma survey com 89 respondentes, especialmente controllers, cujas percepções foram avaliadas de acordo com as três variáveis mencionadas, mediante análise multivariada (ANACOR e HOMALS).
Resultados: Os resultados revelam que organizações com culturas organizacionais mais fortes estão diretamente associadas a setores de controladoria mais participativos (níveis mais elevados de parceria da controladoria), os quais utilizam sistemas de avaliação de desempenho mais amplos. Mostram, ainda, ausência de associação direta entre cultura organizacional e amplitude de sistemas de avaliação de desempenho. Contribuições: Para a academia, evidenciar a compreensão da associação direta entre NPC e ASADO e a impossibilidade de mostrar associação direta entre CO e ASADO. Com isso, o estudo transcende as usuais abordagens explicativas da Teoria da Contingência. Para a prática profissional, sobretudo para os responsáveis pela área de controladoria, oferece uma visão clara da associação de culturas organizacionais fortes com níveis superiores de parceria da área, e desta com a maior amplitude dos sistemas de avaliação desenvolvidos pela área.
Deleuze’s reading of the Critique of Pure Reason
Authors: Pachilla Pablo
Published: October 2021

The aim of this paper is to provide an analysis of Gilles Deleuze’s interpretation of the Critique of Pure Reason such as it appears in his 1963 monographic work La Philosophie critique de Kant. We will show that the originality of Deleuze’s reading lies in reading the critical project in retrospect, taking the sensus communis problem from the Critique of the Power of Judgment and applying it to the first Critique. In so doing, he points out the survival of a pre-established harmony, now interiorized, both between heterogeneous faculties and between the matter of phenomena and the Ideas of reason. This implies a reinterpretation of the critical project that has passed unnoticed within Kantian studies and that places the Third Critique as the ground of the previous ones, unveiling common sense as a condition of possibility of knowledge.
Validación de contenido y adaptación de la escala de sentido de coherencia 29 para la población colombiana
Authors: Sánchez Palacio Natalia , Vélez Álvarez Consuelo , Betancurth Loaiza Diana Paola
Published: October 2021

Objetivo: Validar el contenido de la escala de sentido de coherencia 29 para la población colombiana, la cual mide la capacidad de las personas para aprovechar los recursos materiales e inmateriales que dispone para enfrentar los estímulos presentes a lo largo de la vida. Metodología: Investigación del tipo validación de instrumentos, realizada bajo la técnica de juicio de expertos. El procedimiento contiene cinco pasos: preparación de instrucciones y planilla, selección de expertos, explicación del contexto, discusión y establecimiento de acuerdos. Los criterios de calidad valorados para la validación de contenido fueron: “pertinencia”, “relevancia”, “utilidad”, “suficiencia”, “claridad” y “apariencia”. Se contó con el consentimiento informado de los participantes. Resultados: La escala de sentido de coherencia fue adaptada acorde con ciertos términos desde el punto de vista semántico y sintáctico, y según las pruebas realizadas, posee buena consistencia interna, con un Alfa de Cronbach de 0,838 y un valor global del índice de validez de contenido considerado como esencial de 0,83. Conclusiones: Los hallazgos cuantitativos y cualitativos del proceso de validación confirman que la escala en versión español puede ser aplicada en población colombiana, con el fin de medir el sentido de coherencia, entendido como la capacidad de aprovechar los recursos para enfrentar los estímulos.
Evaluación psicométrica de la escala de calidad de servicios de atención en donantes de un banco de sangre en Medellín, Colombia, 2019
Authors: Tabares Molina Erika Johanna , Hernández Ramírez Brayan
Published: October 2021

Objetivo: Evaluar la adaptabilidad del modelo Service Quality (SERVQUAL), con el fin de valorar la calidad del servicio en la atención de los donantes de un banco de sangre en la ciudad de Medellín. Metodología: Se llevó a cabo una evaluación psicométrica en 301 donantes de sangre, para determinar la calidad percibida. Se realizaron pruebas de consistencia interna con alpha de Cronbach e índice de discriminación, y se evaluó la validez de contenido de los dos cuestionarios y la estructura factorial, mediante análisis factorial exploratorio. Resultados: El alpha de Cronbach fue de 0,86; en las subescalas de expectativas, 0,87, y en percepciones, 0,77. Se observó una mayor consistencia interna en el cuestionario de expectativas que de percepciones. Aunque se obtuvo una baja consistencia interna en algunas dimensiones, no se afecta la escala de manera global. Conclusión: La escala SERVQUAL presenta un adecuado desempeño psicométrico y, por tanto, es útil para evaluar la calidad percibida en la atención en donantes de sangre, siempre y cuando sea abordada de forma unidimensional.
Evaluation of Trichoderma asperellum B1902 in Controlling Fusarium Wilt of Cavendish Banana Cultivar
Authors: Syd Abdul Rahman Sharifah Siti Maryam , Mohd Zainudin Nur Ain Izzati , Abd. Aziz Nor Azwady
Published: October 2021

Trichoderma species is one of the microorganisms with antagonistic properties as biological control agents. In the banana industry, Fusarium wilt disease caused by Fusarium oxysporum f. sp. cubense (Foc) has been practically managed using chemical pesticides that led to environmental disruptions, ineffective conditions and disease resistance. In preliminary study, T. asperellum gave better result compared to other species in inhibiting the growth of Foc in in vitro condition. Therefore, the aim of this study was to examine the effects of T. asperellum as a biological control of Fusarium wilt disease of banana. A total of 326 fungal isolates were isolated from soil samples obtained around Malaysia and identified as Trichoderma species based on phenotype characteristics. The species identity for the best candidates from dual culture test was confirmed based on internal transcribed spacers (ITS) and translation elongation factor 1 alpha (TEF-1α) sequence identity. In dual culture test, findings showed that three isolates with a high percentage inhibition of radial growth (PIRG) were observed in plates of T. asperellum isolates B1902 (84.85%), T2007 (77.78%) and C1667 (75.76%), which successfully inhibited the growth of F. oxysporum f. sp. cubense isolate 9888. Based on in vivo test, the best candidate was T. asperellum B1902 with lower disease severity index (DSI) value of 0.2 compared to the inoculated control with DSI of 3.6. As a conclusion, T. asperellum B1902 can be used as an alternative treatment in managing Fusarium wilt disease. Hence, future study should be focused on applying T. asperellum as a biocontrol agent in the field and controlling other plant diseases in the agricultural plantation.
Biological Activities and Chemical Profiles of Selected Soil Fungi Isolated from Sirindhorn Peat Swamp Forest of Narathiwat, Thailand
Authors: Dej-adisai Sukanya , Kaewchutima Narisorn , Wattanapiromsakul Chatchai , Phoopha Sathianpong
Published: October 2021

A total of 54 soil fungi were collected from Sirindhorn peat swamp forest in Narathiwat Province which is the last peat swamp forests in Thailand. They were extracted using four different solvents and 104 crude extracts were obtained. The bioactivity screening of these samples was done employing alpha-glucosidase inhibition, anti-inflammation using nitric oxide inhibition and cytotoxicity using cancer cell line (MCF-7). The results showed that SPSF224 crude extract had the best biological activities in the screening tests and was then selected for further study. The SPSF224 was identified as Penicillium maximae. The crude extracts of P. maximae were determined for chemical profile, IC50 value of alpha-glucosidase inhibition, antioxidant and antimicrobial activities against Staphylococcus aureus, Trichophyton mentagrophytes, and T. rubrum. This was the first report of chemical investigation and biological activity evaluation of P. maximae.
In-Silico Characterization and Expression Analysis of NB-ARC Genes in Response to Erwinia mallotivora in Carica papaya
Authors: Abu Bakar Nur Syazana , Saidi Noor Baity , Rozano Lina , Abdullah Mohd Puad , Supian Suhaina
Published: October 2021

Disease resistance in plants is commonly associated with resistance (R) genes that encode nucleotide binding site-leucine rich repeat (NBS-LRR) domains that are essential for pathogen recognition and defence signalling. In this study, we identified and analyzed the sequence of putative pathogen-responsive NB-ARC transcripts from Carica papaya transcriptome database, carried out the structural and phylogenetic analysis, and determined the expression profile of the transcripts in C. papaya challenged with Erwinia mallotivora. The findings indicate CpNBS1, the only pathogen-responsive NB-ARC protein identified in this study belongs to the CC-NBS-LRR group. Semi-quantitative PCR showed CpNBS1 was differentially expressed in response to E. mallotivora. Structural analysis of the 4993-Eksotika and 4993-Viorica translated proteins showed striking differences in terms of the number of β-sheets and α-helixes as well their ligand-binding surface, suggesting the role of the LRR domain in determining the specificity of recognition of E. mallotivora effector. Collectively, this study provides new insights into the role of NBS-LRR genes in C. papaya and its implications for enhancing of plant disease resistance through genetic engineering.
Alkaloid Caulerpin and Cytotoxic Activity against NCL-H460 Lung Cancer Cells Isolated along with β-sitosterol from the Halimeda cylindracea Decaisne
Authors: Dini Iwan , Soekamto Nunuk Hariani , Firdaus Firdaus , Supratman Unang , Latip Jalifah
Published: October 2021

Alkaloid caulerpin (1), along with β-sitosterol (2), were isolated from the n-hexane extract of the macroalga Halimeda cylindracea Decaisne. The chemical structure was identified by a spectroscopic method including IR, MS, UV, NMR 1D, NMR 2D, and comparison with data of spectra previously reported. Compounds (1) and (2) were isolated for the first time from this macroalga. Compund (1) were evaluated for their cytotoxicity activity against NCL-H460 lung cancer cells in vitro and showed moderate activity with IC50 value of 20.05 µg/mL.
Diversification of Agricultural Areas in Indonesia using Dynamic Copula Modeling and K-Means Clustering
Authors: Ahdika Atina , Kartikasari Mujiati Dwi , Dini Sekti Kartika , Ramadhani Intan
Published: October 2021

Agriculture is one of the main pillars of economic growth in Indonesia. Failure in this sector can result in faltering economic stability of the country. Thus, to minimize these failures, mapping of areas with particular commodity potential is needed. One of the main factors affecting the growth of crops is rainfall. Therefore, this paper aims to model the potential distribution of commodity growth based on rainfall precipitation using dynamic copula. The modeling results are then used as a basis for grouping the potential of food crop commodities in Indonesia. The determination of the group was carried out using the k-means clustering method. We expect that the result of the modeling can provide an overview for farmers or the government to make policies related to the optimization of Indonesia's agricultural sector. This result will enable the government to offer facilities that can minimize agricultural losses, such as superior seeds that are resistant to weather changes and the provision of training for enhancing farming skills. In addition, it is also suggested to diversify farm areas to reduce the failures due to dependence on a single agricultural product.
Yeni Bir Hücre Ölüm Şekli Olarak Ferroptozis
Authors: ÇELENK Alper
Published: October 2021

Ferroptozis, geleneksel apoptoz ve nekrozdan farklılık gösteren, demir bağımlı lipid peroksit birikiminden kaynaklanan ve yeni keşfedilen bir hücre ölüm şeklidir. Bu hücre ölümü, hücre hacminin küçülmesi ve artan mitokondriyal membran yoğunluğu dahil olmak üzere sitolojik değişiklikler ile karakterize edilmektedir. Morfolojik olarak, mitokondriyal membran yoğunlaşması ve ruptürü, mitokondriyon kristalarının küçülmesi veya yok olması ile mitokondri normalden daha küçük görülebilir. Ferroptozis, sınıf 1 ve sınıf 2 ferroptozis indükleyiciler olarak bilinen iki küçük molekül sınıfı ile indüklenebilir. Bu moleküllere ek olarak sorafenib ve artemisin türevi ilaçlar tarafından da uyarılabilmektedir. Kanser hücrelerinde ve böbrek tübül hücreleri gibi bazı normal hücrelerde, bu ilaçlar ve sınıf 1 ve 2 ferroptozis indükleyiciler ile ferroptozis tetiklenebilmektedir. Mitokondriyal voltaj bağımlı anyon kanallarının ve mitojen ile aktive olan protein kinazların aktivasyonu, endoplazmik retikulum stresinin artması ve sistin-glutamat taşıma sisteminin inhibisyonu da ferroptozisin indüklenmesinde rol oynamaktadır. Bu durum, demir metabolizmasından türetilen lipit peroksidasyon ürünlerinin ve reaktif oksijen türlerinin (ROS) birikmesi ile oluşmaktadır. Ferroptozis, demir şelatörler (örn., Deferoksamin) ve lipid peroksidasyon inhibitörleri (örn., Ferrostatin) tarafından inhibe edilebilir. Ferroptozis, lenfositoma, pankreas duktal hücre kanseri, renal hücreli karsinoma (RCC) ve hepatosellüler karsinoma (HCC) gibi bazı tümör hücrelerinin proliferasyonunda etkin bir rol oynamaktadır.
Analisis Ketentuan Hak Tanggungan Elektronik pada Peraturan menteri Agraria dan Tata Ruang Nomor 9 Tahun 2019 tentang Pelayanan Hak Tanggungan
Authors: Amalia Nailu Vina , Qurbani Alifia Soraya , Kumara Salvian
Published: October 2021

The purpose of this study is to analyze the provisions on Electronic Mortgage. The study uses normative-empirical legal research methods. The approach used is included in the category of Non-Judicial Case Study, which is a legal case study approach without conflict. The data in this study are secondary data obtained from literature sources and existing sources. The analysis used is a descriptive qualitative analysis that describes the actual state of a particular fact. Based on the Regulation of the Minister of Agrarian Affairs and Spatial Planning on Electronic Integrated Mortgage Rights Services, it provides various facilities in its submission. There are several gaps in the regulation that can be used to disadvantage certain parties so that the regulation still needs improvement so that it does not produce a premature product.
Essential Facilities Doctrine Untuk Membatasi Hak Eksklusif Paten
Authors: Pramoediyanto Fidyani Leirta
Published: October 2021

This study aimed to discuss the exclusive rights of patents and the efforts to limit them through freedom of fair business competition. The study used normative legal research methods with a statutory approach and a conceptual approach. Data analysis was descriptive analysis. The results showed that the exclusive rights in patents were limited by several provisions to eliminate fair business competition. An exclusive right to a patent owner was a patent right was to use the patent and prohibits other parties from using, producing, distributing, selling, leasing or otherwise without the permission of the patent owner. Patents were limited to a period of 20 years after which they could be used by the public. Restrictions on patents as intellectual property by considering account aspects of public interest, public order, morals and religious morals. The essential facilities for doctrine were one of the efforts to overcome the abuse of exclusive rights, namely by requiring business actors to give opportunities to their competitors to use these important facilities owned by patent holders.
Penerapan Model Pembelajaran Teams Games Tournament Berbasis Ranking One Civic Education Untuk Meningkatkan Hasil Belajar Siswa
Authors: Laili Innayatul , Dayati Umi , Rochmadi Nur Wahyu
Published: October 2021

The purpose of this study was to explain the feasibility of learning using the team games tournament-based Ranking One Civic Education (ROCE) model in teaching and learning activities on Pancasila and Civic Education (PPKn) subjects and to analyze the improvement of student learning outcomes after the ROCE Game-based learning method was applied to PPKn subjects. This study used a classroom action research approach with qualitative and quantitative data as material for analysis. This study used two cycles with two meetings for each cycle. As for the process of implementing the ROCE Game, it was found that 13-14 indicators were carried out well in cycle I, while in the learning process in cycle II, an average of 15 indicators were obtained from a total of 17 indicators of learning implementation by teachers. In the first cycle, an average of 11 indicators was obtained and in the second cycle, an average of 12-13 indicators was obtained from a total of 14 indicators of learning implementation by students. The increase in learning outcomes taken based on the post-test score in cycle I was 77.7%, then an increase in the post-test score in cycle II became 86.1%. So, tournament-based teams games learning model Ranking One Civic Education could increase student learning outcomes.
Analisis Yuridis Penyimpanan Minuta Akta Notaris Secara Elektronik
Authors: Engelbert Lendo Theo , Widhianti Hanif Nur , Wisnuwardhani Diah Aju
Published: October 2021

This study aimed to discuss and analyze problems regarding the storage of minutes of notary deeds made electronically. This study used a normative research method. The approach used a statutory approach and a conceptual approach. The minutes of the notarial deeds can be made electronically because they were permitted by several regulations. Electronic deed minutes can be stored as long as the original deed was still made and stored conventionally. The validity of the position of the minutes of the determined that was stored electronically as evidence was determined by the judge's consideration.
Perilaku Menyimpang Mahasiswa dalam Kinerja Akademik di Perguruan Tinggi
Authors: Mawarti Rista Ayu , Hakim Suparlan Al , Habibi Muhammad Mujtaba , Pramesti Lilya Windi , Shofa Abd. Mu'id Aris , Alfaqi Mifdal Zusron
Published: October 2021

This study aimed to describe the forms, causes, and efforts to minimize the occurrence of deviant behavior patterns in college students. This study used a qualitative approach with the type of case study research. The main subjects in this study were students of the Pancasila and Citizenship Education Study Program, Faculty of Social Sciences, State University of Malang, who were supported by the involvement of lecturers and teaching staff as supporting informants. Observations, interviews, and documentation were used as procedures for data collection techniques. Data analysis was carried out through several stages, including data reduction, data presentation, and drawing conclusions. The results of the study showed that there were three forms of student deviant behavior in academic performance, namely the fabrication of research proposals in the Pancasila and Citizenship Education Seminar, falsification of assignments for the Personality Psychology course, and plagiarism of Public Policy course assignments. The causes of this deviant behavior were laziness, lack of time management, and lack of learning discipline. The two-way communication process through deliberation and delivery of commitments to improve behavior was chosen as an effort to minimize the occurrence of deviant behavior in academic performance in universities.
Perbandingan Tindak Pidana Makar dalam KUHP Indonesia, Malaysia, Austria dan Konsep Hukum Islam
Authors: Silfiah Rossa Ilma
Published: October 2021

This study aimed to analyze the forms of treason and a comparison of the criminal acts of treason against the Indonesian, Malaysian, Austrian, and Indonesian Criminal Codes and the concept of Islamic law. The research used a normative law with a statutory approach and a comparative approach. The research data were analyzed descriptively. The results of this study found that forms of treason included treason that attacked the legal interests of the head of state, territorial integrity, and government. The crime of treason in Indonesia was distinguished between crimes against security within the country and outside the country, both committed by diplomats and the military. Sanctions for perpetrators of the crime of treason in Malaysia range from the threat of capital punishment, imprisonment, and fines. The crime of treason in Austria did not affect the sentence and did not distinguish between crimes against justice and against the government, all those involved in treason were sentenced to death. The concept of Islamic law provided an extraordinary warning for perpetrators of treason against the government because state security greatly determined the smooth running of worship and the welfare of all citizens.
NILAI-NILAI ENTREPRENEUR PADA BUKU TEKS MATA PELAJARAN SEJARAH DAN IMPLEMENTASINYA DI SMA NEGERI 1 INDRALAYA
Authors: Dhita Aulia Novemy , Asmi Adhitya Rol , Yunani Yunani
Published: October 2021

Historical events have a lot of treasure that contains learning values, one of which is entrepreneurial values. This value is very important in educating students, with historical material in textbooks such as Arrived Hindu-Buddha in Indonesia, Hindu-Buddha Kingdom in Indonesia, Islam Kingdom in Indonesia, and History of Colonial in Indonesia, which so far have only been memorized as events only. The great potential contained in the history textbook, becomes the background for analyzing the values of entrepreneurs in the use of history textbooks in Senior High School Number 1 in Indralaya. This study aims to get clear any material that contains the values of entrepreneurs in history textbooks at Senior High School Number 1 in Indralaya. The method used in this research is naturalistic qualitative research. Data collection is done by observation, documentation, and triangulation, while data analysis is done by reducing, describing data and drawing conclusions. The results showed that history textbooks contain entrepreneurial values that are independent, creative, risk-taking, action-oriented, leadership, hard work, concepts and skills Masa lalu menyimpan banyak harta karun yang mengandung nilai-nilai pembelajaran, salah satunya nilai-nilai entrepreneur. Penerapan nilai-nilai entrepreneur tidak hanya melalui kegiatan praktek wirausaha, tetapi dapat diterapkan melalui buku teks pelajaran, sehingga mengandung niai-nilai entrepreneur. Salah satunya buku teks mata pelajaran sejarah SMA. Sangat penting untuk mengetahui kandungan entrepreneur dalam buku teks mata pelajaran sejarah SMA dan penerapannya di sekolah. Potensi besar yang terdapat dalam buku teks sejarah tersebut, menjadi latar belakang untuk melakukan analisis nilai-nilai entrepreuner dalam penggunaan buku teks mata pelajaran Sejarah di SMA Negeri 1 Indralaya.Penelitian ini bertujuan untuk mendapatkan secara jelas materi apa saja yang mengandung nilai-nilai entrepreneur dalam buku teks mata pelajaran Sejarah  dan implementasinya di SMA Negeri 1 Indralaya. Metode yang digunakan dalam penelitian ini adalah penelitian kualitatif naturalistik. Pengumpulan data dilakukan dengan observasi, wawancara, dokumentasi dan triangulasi. Sedangkan analisis data dilakukan dengan mereduksi, menguraikan data dan menarik kesimpulan. Hasil penelitian menunjukkan bahwa buku teks sejarah mengandung nilai-nilai entrepreneur yaitu mandiri, kreatif, berani mengambil resiko, berorientasi pada tindakan, kepemimpinan, kerja keras, konsep dan skill/keterampilan. Implementasi nilai-nilai entrepreneur yang terkandung dalam buku teks mata pelajaran sejarah, dilakukan secara tidak langsung oleh guru sejarah, dalam berbagai kegiatan di sekolah. KATA KUNCINilai, Entrepreneur, Buku Teks, Sejarah
WATERS TOWARDS RICE TRADE FLOW IN 14TH CENTURY OF JAVA
Authors: Surya Riza Afita , Fikriya Rif'atul
Published: October 2021

Waters as rain, rivers, and seas are one the most common feature found upon Southeast Asian region. It has been establishing this region significantly distinctive along with others. Water is such profound thing everywhere, but it helds most importantly in Southeast Asia Maritime region, with its long shorelines in relation to it landmass, and with the enormous expanses of surrounding Island of Southeast Asia and abutting the shores of Mainland Southeast Asia. Waters in form such rain, rivers, and seas undoubtly giving a certain pattern of social and economical circumstance towards society. Java was known as the biggest rice producer until 19th century, especially manufactured among Javanese kingdoms. Rice had been the trademark of exchange in Java that was contributed across the land overtime. Here, wet rice cultivation has been a typical technique engaged in Java and remains until presents. This article discusses the water impact towards rice trade in Java during 14th century.
Increased Interest in Science Learning Through Integrated Learning of Local Snacks with The Discovery Learning Model
Authors: Nisa Wilda Muhimmatun , Wilujeng Insih , Pradana Diego
Published: October 2021

This study aimed to determine the interest in learning science after using integrated learning of local snacks in Cangkringan with Discovery Learning model at Cangkringan Junior High School 1. This study is a pre-experimental design that used a onee-group pretest-posttest design. The sample in this study were 31 students of class VIIIA lesson 2019/2020. Data collection techniques by using a observation and questionnaire of interest in learning before and after treatment in order to measure student interest in learning. Observations carried out by holding observations of activities that are taking place in class. The indicator of learning interest instruments, in the questionnaire is interest, pleasure, attention, and desire or awareness. Learning interest data generated in the form of scores (quantitative data) with 4 scale were strongly agree (SS), agree (S), less agree (KS), and disagree (TS). The questionnaire was developed by researchers by showing indicators of interest in learning with 23 questions. Data analysis techniques by using N-Gain analysis techniques and descriptive analysis by converting the results of percentage analysis. the result showeed that the students' interest in learning science after implementation of integrated learning of local potential with discovery learning models increases with an N-gain score of 0.59 in the medium category. The average percentage value of descriptive analysis of student learning interest has increased from 72.01 percent with moderate criteria to 88.56 percent with high criteria.
Acute Transient Macular Edema after Uneventful Cataract Surgery
Authors: Beisekeeva J. S. , Bezrukov A. V. , Kochergin S. A. , Samoylenko A. I.
Published: October 2021

Purpose: to provide a clinical case of recurrent keratoconus from our practice.

Materials and method. A patient came to the clinic with a complaint of decreased visual acuity in the right eye. A series of standard instrumental examinations and Scheimpflug keratotopography were performed, and astigmatism of the right eye was diagnosed. Similar examinations were carried out during the patient’s attendance at follow-up examinations.

Results. Based on the results of scanning Scheimpflug keratotopography, the diagnosis of keratoconus (forme fruste) was made. On examination after 1 year, there were no complaints of decreased visual acuity and data from the same instrumental examinations indicating keratoconus. After this examination, the patient came 3.5 years later with complaints of a new decreased visual acuity in the right eye. During instrumental examinations and keratopography, data were obtained indicating the presence of posterior keratoconus. After 1 year, a follow-up examination took place without complaints. The data of instrumental studies are identical to the previous visit; keratotopography revealed a decrease in posterior elevation.

Discussions and conclusion. It was revealed that the patient was constantly taking the hydroxyurea drug against the background of systemic disease up to the 3rd visit, at the time of the 4th visit she had not taken it for 1 year. There are publications in the literature on the effect of this type of drugs on the collagen of the dermis of the skin, the type of which corresponds to the collagen of the cornea. We hypothesize that drugs may have an effect on the biomechanical properties of the cornea, which requires further in-depth study.
Expert (Medical) Assessment of the Main Patients Complaints with Computer Visual Syndrome
Authors: Ovechkin I. G. , Kovrigina E. I. , Leksunov O. G. , Konovalov M. E.
Published: October 2021

The purpose is to conduct an expert (medical) assessment of the main complaints of patients with symptoms of computer visual syndrome (CVS).

Methods: as part of the preliminary stage of work, an individual interview was performed (according to the standard developed methodology) with 100 patients aged 24–36 years, whose professional daily activity (at least 2 years) was characterized as visually-intense work associated with electronic systems displaying information (at least 4 hours a day) and with a fairly high level of responsibility for the final result. During the main stage of the study, a special questionnaire was developed, in which the identified complaints were transformed into questions. The task of the expert — ophthalmologist was to assess the relevance of each of the questions in terms of the severity of the impact on the “quality of life” of the patient. In this case, the assessment was carried out on a 10-point scale, where 0 points — the question is not relevant; 10 points — the question is very relevant. The study involved 96 ophthalmologists aged 41.3 ± 1.6 years (age range from 32 to 62 years) with an average of 17.3 ± 1.4 years of professional experience (range from 6 to 37 years).

Results: more pronounced “ocular” manifestations of the CVS were established (mean score — 8.0 ± 0.2, range from 5.0 to 9.4 points, the highest scores for 8 complaints from 8.6 to 9.4 points) compared with “visual” (average score — 6.5 ± 0.2, range from 4.1 to 8.8 points, the highest scores for 5 complaints from 7.8 to 8.8 points). A sufficiently high level of practical significance of “professional” subjective manifestations of the CVS has been established.

Conclusion. The obtained data can be basic in the framework of the prospective development of a questionnaire for assessing the “quality of life” of patients with CVS symptoms, since the use of an expert (medical) assessment of identified complaints from the position of the severity of a change in subjective status significantly increases the level of reliability, reliability, as well as meaningful and constructive validity methods of assessing the “quality of life”.