bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of PSA at death in patients with metastatic castration-resistant prostate cancer.
Authors: Bikkasani Krishna , Qin Qian , Lin Justin , Galsky Matt D. , Liaw Bobby Chi-Hung , Oh William K. , Tsao Che-Kai
Published: March 2019

184

Background: Prostate Specific Antigen (PSA) is a valuable prognostic and predictive biomarker in prostate cancer (PC). Currently, the significance of PSA at death is undefined. In this single institution retrospective study, we aim to characterize the significance of PSA at death in patients with metastatic castration-resistant prostate cancer (mCRPC). Methods: Using the Mount Sinai Genitourinary (GU) Cancer Biorepository, an IRB approved database containing all consented GU cancer patients seen between 2010-2018, we stratified patients into the following cohorts based on their PSA at death: < 10, 10-100, 100-1000, and > 1000 ng/ml. We excluded data of patients who had less than 3 visits to the Mount Sinai Hospital. A descriptive analysis was performed to assess clinical characteristics of disease, treatment response, and outcomes. Results: We identified 1097 PC patients, and 101 were found to be deceased following a diagnosis of mCRPC. Cohorts of higher PSA level at death were associated with: a lower Gleason score at diagnosis, a longer time to castration resistance, higher burden of metastatic disease at death (non-visceral and visceral), and longer OS in patients with mCRPC (see table). Conclusions: In this study, PSA at death is associated with several important clinical characteristics and outcome, including overall survival. These differences may be attributed to their underlying biologic behavior. These results are hypothesis generating, and larger studies will be needed to further assess the significance of these findings. [Table: see text]
Clinical outcomes in Caucasian (C), African American (AA) and Asian men with metastatic castration-resistant prostate cancer (mCRPC).
Authors: Halabi Susan , Dutta Sandipan , Chi Kim N. , Tangen Catherine M. , Petrylak Daniel Peter , Araujo John C. , Fizazi Karim , Quinn David I. , Higano Celestia S. , Tannock Ian , Small Eric Jay , Kelly William Kevin
Published: March 2019

186

Background: We have previously shown in multivariable analysis that African American (AA) men had 19% lower risk of death than Caucasian (C) men with metastatic castration resistant prostate cancer (mCRPC) treated with a docetaxel (D) prednisone (P) based regimen. The primary goal of this analysis was to compare progression-free survival (PFS) and PSA PFS in C men, AA men, and Asian men with mCRPC treated with a DP based regimen. Methods: Individual patient data from 8,820 mCRPC men randomized on nine phase III trials to a DP containing regimen were combined. Race used in the analysis was based on self-report. The endpoints were PFS and PSA PFS. Per protocol definition of PFS was used in the analysis while PSA PFS was defined per PCWG3 criteria. The proportional hazards model was used to assess the prognostic importance of race in predicting PFS and PSA PFS, adjusting for treatment arm and prognostic factors that were common across the trials (performance status, and sites of metastases). Results: Of 8,820 patients, 7,528 (85%) were C, 500 (6%) were AA, 424 (5%) were Asian and 368 (4%) had race unspecified. Men with race unspecified were excluded from the analysis, leaving 8,452 men. Median PFS was 8.3 months (m) (95% CI = 8.1-8.5), 8.2 m (95% CI = 7.4-8.8), and 8.3 m (95% CI = 7.6-8.8) in C, AA and Asian men, respectively. In multivariable analysis adjusting for risk factors, the pooled hazard ratios for AA vs. C was 1.04 (95% CI = 0.94-1.15, p-value = 0.461) and 1.08 (95% CI = 0.96-1.21, p-value = 0.192) for Asian vs. C. PSA data were available for 6,685 (89%) C, 456 (91%) AA and 412 (97%) Asian men. Median PSA PFS were 9.7 m (95% CI = 9.4-10), 8.5 m (95% CI = 7.6-10) and 10.0 m (95% CI = 9.5-11.8) in C, AA and Asian, respectively. In multivariable analysis, the pooled hazard ratios were 1.05 (95% CI = 0.94-1.16, p-value = 0.408) for AA vs. C and 1.00 (95% CI = 0.82-1.22, p-value = 0.996) for Asian vs. C. Conclusions: There were no differences in PFS and PSA PFS outcomes in C, AA, or Asian men with mCRPC enrolled on these phase III clinical trials with DP. Clinical trial information: NCT00004001.
Docetaxel in older patients for metastatic prostate cancer.
Authors: Mark Frances May , Pollard Adam , Thomson Alastair H
Published: March 2019

187

Background: Docetaxel use has led to a significant prolongation in overall survival in metastatic prostate cancer (MPC). There is however limited information on treatment tolerance and outcomes in patients 80 years old and over in routine clinical practice. With the ever aging population it is becoming more important to assess outcomes in this age group. Methods: Patients diagnosed with MPC and treated with docetaxel from 2006 to 2016 were identified and their records retrospectively reviewed via electronic clinical and prescribing systems in a single centre in the UK. Data was assessed for prostate specific antigen (PSA) response, number of cycles and dosing of docetaxel and castrate resistant overall survival (OS). Results: 209 consecutive patients with MPC receiving docetaxel were reviewed. Three patient groups were identified; younger than 75 years old (n = 150, 37 early (as part of initial therapy) docetaxel), 75-79 years (n = 40, 2 early docetaxel) and 80 years or over (n = 19, no early docetaxel). When comparing mean OS excluding early docetaxel treatment, respective mean survival times for each of the three age groups, younger to older were 1001, 1045 and 1294 days, with between class difference being insignificant. The PSA response rates to docetaxel excluding first line use were compared between the age groups and did not show a significant difference at 39% in the youngest group, 38% in the intermediate age group and 42% for the oldest patients. There was a trend that the older the patient, the more likely docetaxel was the final systemic treatment given at 42% (80 years or over), 32% (75-79 years) and 23% (younger than 75 years). The 80 years or over group received fewer docetaxel cycles (3.8, p = 0.006) and less dose per course (226mg/m2, p = 0.004) than the group less than 75 years (5.8 cycles, 409mg/m2) and 75-79 years (5.1 cycles, 341mg/m2). Conclusions: In this group of patients, in routine clinical practice, the 80 years and over age group received fewer cycles of docetaxel in MPC and less dose per course, but nevertheless achieved similar PSA response rates and castrate resistant OS. Given these results, docetaxel should be considered as a treatment option in suitable patients of 80 years and over.
Whole blood FOLH1 mRNA expression and treatment response in metastatic castration-resistant prostate cancer (mCRPC).
Authors: Kwan Edmond Michael , To Sarah Q , Fettke Heidi C , Docanto Maria M , Bukczynska Patricia , Mant Andrew Michael , Pook David William , Ng Nicole , Graham Lisa-Jane K , Segelov Eva , Mahon Kate , Davis Ian D. , Parente Phillip , Pezaro Carmel Jo , Horvath Lisa , Azad Arun
Published: March 2019

188

Background: Identifying predictive biomarkers for mCRPC patients receiving androgen receptor signalling inhibitors (ARSI) or chemotherapy remains an unmet clinical need. FOLH1 encodes for Prostate-Specific Membrane Antigen (PSMA), a type II glycoprotein highly expressed on prostate cancer cells. We designed a whole blood assay to detect FOLH1 mRNA, and correlated expression with clinical outcomes in patients commencing ARSI (abiraterone or enzalutamide) or chemotherapy (docetaxel or cabazitaxel). Methods: mCRPC patients commencing ARSI or chemotherapy were prospectively recruited at three Australian centres from June 2016 to July 2018. A quantitative reverse transcription polymerase chain reaction assay was used to detect FOLH1 transcript from whole blood samples collected in PAXgene® RNA tubes. Pre-treatment FOLH1 expression was correlated with PSA response rate (Fisher’s exact test) and PSA progression-free survival (PSA-PFS) (log-rank test). Results: Median follow-up was 13.6 months (IQR 9.7–19.3). In total, 88 pre-treatment samples were analysed, of which 75 (85%) were FOLH1-positive. In patients receiving ARSI, outcomes favoured FOLH1-positive patients compared to FOLH1-negative patients, with higher PSA response rates (39/60, 65% vs. 2/7, 29%; p = 0.1) and longer PSA-PFS (median 9.0 months [95% CI, 7.2-10.8] vs. 2.8 months [95% CI, 2.3-3.3]; p = 0.03). Conversely, in chemotherapy-treated patients, inferior outcomes were observed in FOLH1-positive patients compared to FOLH1-negative patients, with lower PSA response rates (4/15, 27% vs. 5/6, 83%, p = 0.05) and shorter PSA-PFS (median 2.9 months [95% CI, 2.8-3.0] vs. 4.1 months [95% CI, 3.7-4.5]; p = 0.32). Conclusions: Pre-treatment FOLH1 expression may differentiate between outcomes on ARSI vs. chemotherapy in mCRPC patients. The utility of FOLH1 as a predictive biomarker in mCRPC warrants further evaluation in larger, independent cohorts. [Table: see text]
Decreased Early Mortality in Young Adult Patients With Acute Lymphoblastic Leukemia Treated at Specialized Cancer Centers in California
Authors: Alvarez Elysia M. , Malogolowkin Marcio , Li Qian , Brunson Ann , Pollock Brad H. , Muffly Lori , Wun Ted , Keegan Theresa H.M.
Published: March 2019

PURPOSE:

Studies suggest that patients with acute lymphoblastic leukemia (ALL) have superior survival when treated at specialized cancer centers (SCCs). However, the association of early mortality (< 60 days) with location of initial care, sociodemographic factors, and complications has not been evaluated in pediatric and young adult (YA) patients with ALL.

METHODS:

Using the California Cancer Registry linked to hospitalization data, we identified pediatric and YA patients with ALL who received inpatient leukemia treatment between 1991 and 2014. Patients were classified as receiving all or part/none of their care at an SCC (Children’s Oncology Group– or National Cancer Institute–designated cancer center). Propensity scores were created for treatment at an SCC in each age group. Multivariable, inverse probability–weighted Cox proportional hazards regression models identified factors associated with early mortality. Results are presented as hazard ratios (HRs) and 95% CIs.

RESULTS:

Among 6,531 newly diagnosed pediatric (≤ 18 years) and YA (19 to 39 years of age) patients with ALL, 1.6% of children and 5.4% of YAs died within 60 days of diagnosis. Most children received all of their care at an SCC (n = 4,752; 85.7%) compared with 35.5% of YAs (n = 1,779). Early mortality rates were lower in pediatric patients and those receiving all care at an SCC (pediatric: all, 1.5%, v part/none, 2.4%; P = .049; YAs: all, 3.2%, v part/none, 6.6%; P = .001). However, in adjusted models, receiving all care at an SCC was associated with significantly lower early mortality in YAs (HR, 0.51; 95% CI, 0.32 to 0.81), but not in pediatric patients (HR, 0.77; 95% CI, 0.47 to 1.25).

CONCLUSION:

YAs with ALL experience significant reductions in early mortality after treatment at SCCs.
Plasma Fibroblast Growth Factor 21 Is Associated With Severity of Nonalcoholic Steatohepatitis in Patients With Obesity and Type 2 Diabetes
Authors: Barb Diana , Bril Fernando , Kalavalapalli Srilaxmi , Cusi Kenneth
Published: March 2019

Context

The relationship between plasma fibroblast growth factor 21 (FGF21), insulin resistance, and steatohepatitis has not been systematically assessed.

Objective

To determine if higher plasma FGF21 is associated with worse steatohepatitis on liver biopsy in patients with nonalcoholic fatty liver disease (NAFLD).

Design and Setting

Cross-sectional study in a university hospital.

Patients Interventions and Main Outcome Measures

Patients with a body mass index >25 (n = 187) underwent: (i) euglycemic hyperinsulinemic clamp to assess tissue-specific insulin resistance (IR); (ii) liver magnetic resonance spectroscopy for intrahepatic triglyceride quantification, (iii) liver biopsy (if NAFLD present; n = 146); and (iv) fasting plasma FGF21 levels.

Methods and Results

Patients were divided into three groups: (i) No NAFLD (n = 41); (ii) No nonalcoholic steatohepatitis (NASH) (patients with isolated steatosis or borderline NASH; n = 52); and (iii) NASH (patients with definite NASH; n = 94). Groups were well-matched for age/sex, prevalence of type 2 diabetes mellitus, and hemoglobin A1c. During euglycemic hyperinsulinemic insulin clamp, insulin sensitivity in skeletal muscle and adipose tissue worsened from No NAFLD to NASH (both P < 0.001). Plasma FGF21 levels correlated inversely with insulin sensitivity in adipose tissue (r = −0.17, P = 0.006) and skeletal muscle (r = −0.23, P = 0.007), but not with liver insulin sensitivity. Plasma FGF21 was higher in patients with NASH (453 ± 262 pg/mL) when compared with the No NASH (341 ± 198 pg/mL, P = 0.03) or No NAFLD (325 ± 289 pg/mL, P = 0.02) groups. Plasma FGF21 increased with the severity of necroinflammation (P = 0.02), and most significantly with worse fibrosis (P < 0.001), but not with worsening steatosis (P = 0.60).

Conclusions

Plasma FGF21 correlates with severity of steatohepatitis, in particular of fibrosis, in patients with NASH. Measurement of FGF21 may help identify patients at the highest risk of disease progression.
Skeletal Fragility and Its Clinical Determinants in Children With Type 1 Diabetes
Authors: Chen Suet Ching , Shepherd Sheila , McMillan Martin , McNeilly Jane , Foster John , Wong Sze Choong , Robertson Kenneth J , Ahmed S Faisal
Published: March 2019

Context

Type 1 diabetes (T1D) is associated with an increased fracture risk at all ages.

Objective

To understand the determinants of bone health and fractures in children with T1D.

Design

Case-control study of children with T1D on bone-turnover markers, dual-energy X-ray absorptiometry, and 3 Tesla-MRI of the proximal tibia to assess bone microarchitecture and vertebral marrow adiposity compared with age- and sex-matched healthy children.

Results

Thirty-two children with T1D at a median (range) age of 13.7 years (10.4, 16.7) and 26 controls, aged 13.8 years (10.2, 17.8), were recruited. In children with T1D, serum bone-specific alkaline phosphatase (BAP) SD score (SDS), C-terminal telopeptide of type I collagen SDS, and total body (TB) and lumbar spine bone mineral density (BMD) SDS were lower (all P < 0.05). Children with T1D also had lower trabecular volume [0.55 (0.47, 0.63) vs 0.59 (0.47, 0.63); P = 0.024], lower trabecular number [1.67 (1.56, 1.93) vs 1.82 (1.56, 1.99); P = 0.004], and higher trabecular separation [0.27 (0.21, 0.32) vs 0.24 (0.20, 0.33); P = 0.001] than controls. Marrow adiposity was similar in both groups (P = 0.25). Bone formation, as assessed by BAP, was lower in children with poorer glycemic control (P = 0.009) and who were acidotic at initial presentation (P = 0.017) but higher in children on continuous subcutaneous insulin infusion (P = 0.025). Fractures were more likely to be encountered in children with T1D compared with controls (31% vs 19%; P< 0.001). Compared with those without fractures, the T1D children with a fracture history had poorer glycemic control (P = 0.007) and lower TB BMD (P < 0.001) but no differences in bone microarchitecture.

Conclusion

Children with T1D display a low bone-turnover state with reduced bone mineralization and poorer bone microarchitecture.
Turner Blazes a Trail for Audience Targeting on Television with Operations Research and Advanced Analytics
Authors: Carbajal José Antonio , Williams Peter , Popescu Andreea , Chaar Wes
Published: March 2019

Short abstract: The authors describe how Turner used operations research and advanced analytics to design and implement innovative and integrated forecasting and optimization models to forecast audiences, generate media deals across all Turner networks, and schedule commercials, balancing the objectives of all of the various types of advertising spots.
Analytics Makes Inventory Planning a Lights-Out Activity at Intel Corporation
Authors: Manary Matthew P. , Wieland Brian , Willems Sean P. , Kempf Karl G.
Published: March 2019

The authors document more than a decade of work to develop an automated inventory target-setting process to enable Intel to manage more than $1 billion of finished-goods inventory.
How effective are organ donation committees, and how can they be improved?
Authors: Silva Geeth , Gor Ratan , Patel Nishil , Gupta Shubham , Manivannan Thulashie , Manu Susan , Sharma Ashwini , Gardiner Dale , Cox Benita
Published: March 2019

Background:

Organ donation committees were established in 2008 by NHS Blood and Transplant to improve the rates of organ donation in the UK.

Aims:

The aims of this study were three-fold: to review the role and structure of organ donation committees in England; to assess how effective organ donation committees are at driving improvements; and to make recommendations regarding the future role, responsibilities and structure of organ donation committees.

Methods:

This study adopted a cross-sectional mixed-methods research approach using questionnaires and semi-structured interviews.

Results:

There was a divergence between how each committee functioned and how effective they were in achieving their aims.

Discussion:

There were seven key findings which related to the effectiveness of organ donation committees. These included, but were not limited to, a lack of consistency in how the role of an organ donation committee was viewed by members of NHS Blood and Transplant; and that the influence a chair has within their respective NHS Trust is key to an organ donation committee being effective in achieving its aims.

Conclusion:

A framework and several recommendations were produced and aimed to help improve the effectiveness of organ donation committees.
Patient arrival pattern and waiting time analysis for a tertiary hospital radiology department
Authors: Idigo Felicitas Ugochinyere , Agwu Kenneth Kalu , Onwujekwe Obinna Emmanuel , Okeji Mark Chukwudi , Anakwue Angel-Mary Chukwunyelu
Published: March 2019

Background:

High patient load and ineffective appointment scheduling has been linked to hospital overcrowding. This article investigated the appointment scheduling method, patient waiting times and overall treatment times. These figures were subsequently compared against patient arrival and examination times.

Method:

In total, 768 adult ambulant patients were part of a real-time observation that was conducted in a tertiary hospital's radiology department in Nigeria. The scheduling method, arrival time, treatment time and waiting time for each patient was noted. The analytical software, MATLAB, was used for data analysis.

Results:

A single block appointment time of 7.30 was given to all patients. For any given day, mean patient arrival per hour (arrival rate) was 7 ± 5.4 patients per hour. Patient arrival rate distribution showed a pattern that resulted in the identification of three segments with stable arrival rates: 7:00–10:00, 10:00-13:00 and 13:00-16:00 with arrival rates of 12, 6 and 2 patients per hour, respectively. The mean waiting time was 116.2 minutes.
How can ways of working with others be developed to improve perinatal mental health care?
Authors: Ablett Lucy
Published: March 2019

There is a national drive to improve perinatal mental healthcare, as a significant proportion of maternal deaths are attributed to mental health problems. This report will evaluate how ways of working with others could be developed to improve perinatal mental healthcare, by linking theoretical frameworks and models to practice. There are many ways in which working together can improve perinatal mental healthcare, including partnering with other organisations such as charities to use available resources; developing interprofessional training sessions and communities of practice to enhance learning; encouraging collective leadership to support and motivate staff to advance healthcare practice; and encouraging effective teamwork to reiterate goals and build strong relationships. Systemic changes must be made to improve perinatal mental health care to address people's physical, social and psychological needs.
Mentor, coach, teacher, role model: what's in a name?
Authors: Power Alison , Wilson Alice
Published: March 2019

In its new standards for education and training, the Nursing and Midwifery Council (NMC) states that students should be ‘empowered and provided with the learning opportunities they need to achieve the desired proficiencies and programme outcomes’ ( NMC, 2018a:5 ). This concept of empowerment, with students as active, rather than passive learners, will be supported by the introduction of practice assessors and supervisors, providing personalised support according to the student's proficiency and confidence. The mentor, traditionally perceived as a ‘teacher’, will be replaced by the practice assessor and supervisor as ‘role models’ and ‘coaches’.

A previous article in this series ( Power and Jewell, 2018 ) looked at the introduction of a coaching model of student support in practice. This article will discuss a third-year student midwife's experiences of her final labour ward placement and her reflections on her mentor's approach to student support using the coaching model.
HPV during pregnancy
Authors: Morris Anthea
Published: March 2019

In the run up to HPV Awareness Day on 4 March, Anthea Morris, Director of Better2Know, offers advice on the human papillomavirus and its implications during pregnancy
Claiming damages for psychiatric injury during childbirth
Authors: Symon Andrew
Published: March 2019

The issue of psychatric harm caused to a mother who experienced poor birth outcomes has once again been raised. Andrew Symon reports on YAH v Medway NHS Foundation Trust
The effect of a training program of hearing-impaired children with cochlear implants on the development of their receptive and expressive language
Authors: العتوم نعيم
Published: March 2019

هدفت الدراسة إلى تعرّف أثر برنامج تدريبي للأطفال المعاقين سمعياً من زارعي القوقعة الإلكترونيةفي تنمية اللغة الاستقبالية والتعبيرية. وتكونت العينة من ) 30 ( طفلاً ممن أجري لهم عملية زراعةالقوقعة في مدينة الحسين الطبية في الأردن ووقع اختيارهم قصدياً، وقسموا إلى مجموعتين؛ تجريبية7( سنوات وقدم - وضابطة بالتساوي. وروعي الجنس في المجموعتين، وبلغت أعمارهم ما بين ) 5لهم برنامج تدريبي لمدة ) 3( أشهر، وأشارت النتائج إلى تحسن اللغة الاستقبالية والتعبيرية للأطفالالمعاقين سمعياً إذ ازدادت حصيلة المفردات اللغوية ونمت قدرتهم على استقبال الكلمات والجملالمنطوقة وفهمها، وتحسنت حاسة السمع بشكل ملحوظ، وأصبحت اللغة المنطوقة هي وسيلة تواصلهممع الآخرين، وخلصت النتائج إلى عدم وجود فروق تعزى لمتغيّر الجنس، ويوصي الباحث الجهاتذات العلاقة بالموضوع المبحوث بعقد ورشات عمل تدريبية للآباء والمعلمين حول كيفية تدريبهم لتنميةالمهارات اللغوية للمعاقين سمعياً.
المعوّقات التي تواجه مقدّري ضريبة الدّخل في الأردن وأثرها على // The obstacles that face income tax assessors and the impact on estimate competency (A field study from the perspective of tax assessors)
Authors: النوايسة محمد
Published: March 2019

تهدف الدّراسة إلى تعرّف أثر المعوقات الإدارية والمحاسبية التي يواجهها مقدّرو ضريبة الدّخل على
التقديرات الضريبية التي يقومون بها، بالإضافة إلى تعرّف مدى إدراك مقدري الضّريبة للمتطلبات
الضرورية للتقدير الضريبي. وزّع الباحث ) 140 ( استبانة على مقدري الضريبة. ومن أهم نتائج الدراسة
أن ) 70.9 %( من أفراد العينة يؤكدون على وجود مشكلات إدارية تواجههم أثناء العمل، كما أن المعوقات
،)% الإدارية التي تواجه مقدري الضريبة لها أثر ذو دلالة إحصائية على التقديرات الضريبية بنسبة ) 5.3
وأن ) 74.62 %( من أفراد عينة الدراسة يؤكدون على وجود مشكلات محاسبية تواجههم أثناء العمل
وبنسبة تأثير ) 10.1 %(، الأمر الذي يشير إلى أنّ المعوقات المحاسبية لها تأثير أكثر من المعوقات الإدارية
على التقديرات الضريبية. أوصت الدراسة بضرورة إجراء أبحاث ميدانية لدراسة المعوقات الاجتماعية
والثقافية التي يواجهها مقدرو الضرائب.
لا تعبر الأفكار الواردة في المخطوطة عن أفكار هيئة تحرير المجلة أو عمادة البحث العلمي في جامعة بيت لحم. يعتبر المؤلف
المسؤول الوحيد عن مضمون المخطوطة أو أية أخطاء فيها.
أهمية إنشاء مرجعية موحدة لحوكمة نظام التعليم والتدريب
المهني والتقني في فلسطين // Developing a standardized governance framework for technical education and vocational training systems in Palestine and its importance //
Authors: الزرو صلاح
Published: March 2019

ناقشت هذه الورقة إشكالية الحاكمية التي يواجهها نظام التعليم والتدريب المهني والتقني في فلسطين
بسبب غياب مرجعية موحد لإدارته، وراجعت الورقة أيضاً الجهود الوطنية التي بذلت منذ قيام السلطة
الفلسطينية لإصلاح هذا النظام وتطويره، ليكون قادراً على تدريب الطلبة على المهارات والكفاءات
اللازمة الفلسطيني، والاستجابة لاحتياجات سوق العمل. وقد هدفت الورقة إلى توثيق النقاش الوطني
حول موضوع الحاكمية في هذا القطاع، وإفساح المجال أمام الأكاديميين للمشاركة في هذا النقاش.
اعتمدت الورقة المنهج الكيفي في البحث، إذ وظّفت التجربة الشخصية للباحث بوصفه أحد صناع
2014 . كما أجريت - السياسات المباشرين في قطاع التعليم والتدريب المهني والتقني من 2000
مقابلات شبه مفتوحة مع عينة قصدية من الأشخاص ذوي العلاقة بموضوع الدراسة. ومع إدراكنا التام
على أن اختيار الأسلوب الأفضل لإدارة نظام التعليم والتدريب المهني والتقني وحوكمته في أي دولة
يعتمد على جملة من العوامل الداخلية، فقد دعت الورقة إلى إنشاء هيئة عامة للتعليم والتدريب المهني
والتقني في فلسطين لتتولى إدارة النظام وقيادته، وتنسيق الاستراتيجيات والسياسات العامة، والخطط
التنفيذية المتعلقة بتطوير قطاع التعليم والتدريب المهني والتقني في فلسطين. وناقشت الورقة كذلك
الغاية من هذه الهيئة المقترحة ومسوّغات إنشائها، وأهدافها ومسؤولياتها، وطبيعتها الإدارية، وآفاق
تمويلها.
لا تعبر الأفكار الواردة في المخطوطة عن أفكار هيئة تحرير المجلة أو عمادة البحث العلمي في جامعة بيت لحم. يعتبر
المؤلف المسؤول الوحيد عن مضمون المخطوطة أو أية أخطاء فيها.
Perspectives of Students and Faculty at Bethlehem University towards Plagiarism: Challenges and Solutions // الانتحال/ السرقة الادبية من وجهة نظر الطلاب والهيئة التدريسية في
جامعة بيت لحم: تحديات وحلول
Authors: Dayyeh Imad Abu , Skakiyya Imad
Published: March 2019

This study sought to identify the perspectives of Bethlehem University students and faculty members on plagiarism in academic writing. Three major aspects of plagiarism were explored: awareness of the phenomenon, its causes, and possible solutions. This study was conducted on (727) Bethlehem University freshmen students and (198) full-time and part-time faculty members during the 2014–15 academic year. Data was collected via two electronically administered survey questionnaires: one for students and another for teachers. The results revealed clear differences between the students’ and faculty members’ awareness of plagiarism and attitudes toward the relationship between the prevalence of plagiarism and the existence of a policy against plagiarism. The results also showed that most of the faculty members lack a general awareness of plagiarism. The study further revealed that there was a clear correlation between plagiarism and the difficulties faced by students in writing in English and their misunderstanding of plagiarism as well as the lack of research skills among students. The paper proposes possible practical solutions to address this problem.
Meaning from movement: Blurring the temporal border between animation and comics
Authors: Gowdy Joshua
Published: March 2019

This article is informed by my current research in the communicative potential of animated elements within digital comics. Drawing on the writings of Thierry Groensteen and Barbara Postema, I adopt the viewpoint that comics are a complex system in which individual signs and multiple codes combine and interact to communicate meaning. From this foundation, I propose that animated movement can add additional layers of signification, contributing connotative meaning to mostly denotational images. Within the article I recognize that attempts to incorporate animated elements into digital comics have often inadvertently illustrated the difficult relationship and potential incompatibility between cinematic animation and the specific conventions of comics. This discord can be attributed to competing temporal qualities; cinematic animation is a linear time-based art form while time in comics is illusory and implied largely through space. Eschewing a cinematic approach to animation, my research builds on an observation by Daniel Goodbrey (2013) that animated elements are most successfully employed within panels as short animated loops. Unlike linear animated sequences, the indefinite timing of loops does not challenge comics’ temporal code. As exemplars of this more harmonious application of animation to the comic form, Jen Lee’s ThunderPaw: In the Ashes of Fire Mountain (2012–16) is discussed alongside my current studio work, Tepid Waters (Gowdy 2017), a digital comic in which the use of illusionistic movement is secondary to animated elements that communicate on symbolic or connotative levels.
Utilização da ferramenta request for proposal (RFP) nas vendas de um hotel de negócios / Using the request for proposal (RFP) tool in the sales of a business hotel
Authors: Albuquerque Francivaldo Dos Santos , Bezerra Maria Do Socorro Coelho , Silva Alexandre César Batista da , Braulio Giulia Cipolla , Libonati Jeronymo José
Published: March 2019

O objetivo deste trabalho foi identificar os impactos nas vendas de um hotel de negócios com a utilização da ferramenta RFP. Metodologicamente o trabalho caracteriza-se, quanto aos objetivos, como exploratório e descritivo; com relação aos procedimentos utilizou-se a pesquisa documental, a bibliográfica e o estudo de caso; com relação a abordagem do problema, apresenta-se como uma pesquisa mista.  O estudo foi operacionalizado com a análise de dados financeiros e índices de desempenho da empresa, além de entrevista junto a gerente de vendas do hotel. Os resultados demonstram que apesar dos números apresentados não serem aparentemente significativos, quando analisados separadamente, são importantes em relação aos resultados gerais do hotel, mostrando o potencial da ferramenta. Pode-se concluir que os retornos auferidos comprovam impactos positivos para as vendas do hotel, pois a ferramenta influi não apenas nas vendas de hospedagem, mas também em setores como alimentos e bebidas, eventos, telefonia e lavanderia. Palavras-chave: Hotelaria. Vendas. Request  for proposal. Impactos.
Cuidados e métodos não-farmacológicos de alívio da dor nas gestantes em trabalho de parto / Non-pharmacological Care and Methods of Pain Relief in Pregnant Women in Labor
Authors: Melo Jayane Kelly Gomes de , Barroso Marianna Leite , Alencar Juliana Saraiva de , Bandeira Luiz Arthur Bevilaqua , Melo Antônio Marlos Duarte de , Mesquita Neto Edmar , Oliveira Gislene Farias de
Published: March 2019

A dor é uma experiência sensorial subjetiva, que pode alcançar diferente proporções a depender a pessoa, e, dentre várias causas das quais pode decorrer, representa um sinal de início de trabalho de parto para a paciente. O objetivo do presente estudo foi discutir, à luz da literatura sobre os cuidados e métodos não-farmacológicos de alívio da dor nas gestantes em trabalho de parto. Os resultados revelaram diversas estratégias, dentre elas:  o relaxamento, a terapia do toque, massagem, hidroterapia, técnicas de respiração. Concliu-se que são positivos os resultados do uso dessas estratégias não farmacológicas no trabalho de parto, como coadjuvante no alívio das dores, motivo pelo qual acreditamos ser importante o desenvolvimento de estudos mais contundentes acerca da temática.
Gramaticalização do item linguístico chegar: analisando um verbo de/em movimento no Português / Grammaticalization of the linguistic item "chegar": analyzing a verb of / in moviment in Portuguese Language
Authors: Rocha Nayara Crisley Barreto Brasil Farias , Sousa Valéria Viana
Published: March 2019

Este artigo tem como objetivo apresentar o percurso do verbo chegar rumo a gramaticalização dentro da Língua Portuguesa falada no Brasil (PB) e, em específico, no vernáculo conquistense. Inicialmente, partimos da hipótese de que esse verbo traça um caminho do uso [+ concreto] > [+ abstrato] em perífrases do tipo [V1 (e) + V2], em que V1 é o verbo chegare V2 o verbo principal. Para tanto, delineamos um percurso, de cunho sociofuncionalista sobre o item em estudo, partindo da sua origem etimológica e de dicionários diversos e observando os registros em gramáticas históricas, prescritivas e descritivas.
A Percepção e o Perfil Ambiental de Graduandos de Educação a Distância: Um Estudo de Caso / The Perception and Environmental Profile of Students of Distance Education: A Case Study
Authors: Machado Caroline Silva , Albuquerque José De Lima , Quevedo Andressa Pacífico Franco , Correia Neto Jorge Da Silva , Souza Eliabe Roberto De
Published: March 2019

Esta pesquisa teve por objetivo avaliar a percepção e o perfil ambiental de alunos da Licenciatura em Artes Visuais com ênfase em Digitais da UAEADTEC/UFRPE no Polo Presencial UAB Camaçari/BA.  A pesquisa de natureza qualitativa e quantitativa foi realizada por meio de questionário fechado, aplicado para 26 participantes. Os resultados demonstram incertezas quanto a alguns aspectos relacionados à cidadania e meio ambiente e à percepção discente sobre a inserção da temática ambiental na composição das disciplinas do curso.  Conclui-se, então, que a percepção ambiental dos discentes está em processo de amadurecimento, porém há necessidade de maiores incentivos quanto à participação ativa nas atividades em sala de aula e no ambiente virtual de aprendizagem, assim como o estímulo periódico na reelaboração do projeto pedagógico do curso.
“Casa das Estrelas”: Uma Análise da Infância na Contemporaneidade / “House of Stars”: A Childhood Analysis in Contemporany
Authors: Oleques Bruna Guerra , Zucolotto Marcele Pereira da Rosa
Published: March 2019

Neste artigo, pretende-se investigar a criança e a infância tendo como material de análise o livro “Casa das Estrelas – O universo contado pelas crianças”, uma espécie de dicionário onde o significado das palavras é dito pelas crianças. Pretende-se mostrar o quanto os conceitos de criança e de infância foram se modificando ao longo dos séculos, trazendo, na atualidade,possibilidades de inovação, novidade, inventividade, experiência e historicidade. Aponta-se, com estas considerações, a potência de criação das crianças, seu poder de inventividade e o quanto é importante darmos voz a elas.
Cuidados de Enfermagem ao Paciente acometido por Acidente Vascular Cerebral: Revisão Integrativa / Nursing Care for Patients caused by Cerebral Vascular Accidents: Integration Review
Authors: Carvalho Manoel Renan De Sousa , Miranda Nádia Maria Santos Spíndola , Lustosa Verbena Rodrigues , Silva Bárbara Gomes Santos , Rodrigues Vitória Eduarda Silva , Oliveira Francisco Gerlai Lima , Amorim Júnior José De Siqueira , Santos Rosana Serejo dos , Sousa Júnior Ribeiro de
Published: March 2019

O acidente Vascular Cerebral é apontado como uma das doenças mais incapacitante, pois cerca de 70% das pessoas que são acometidas pela patologia não conseguem retomar as suas atividades diárias e aproximadamente 50% dos indivíduos ficam dependentes de outras pessoas. O estudo objetivou-se em analisar e descrever quais as principais intervenções de enfermagem ao paciente acometido por AVC. O estudo trata-se de uma revisão integrativa onde a busca dos artigos ocorreu no mês de agosto de 2018, foram utilizados os descritores acidente vascular cerebral, assistência ao paciente e enfermagem, cruzados com o operador booleano AND, nas bibliotecas virtuais BVS e SciELO, na PUBMED foram utilizados os descritores cadastrados no Medical Subject Headings (MesH): “Stroke” AND “Patient Care” AND “Nursing”. As buscas resultaram num total de 3723 em todas as bases de dados, onde após os critérios de inclusão e exclusão foram selecionados 09 artigos para compor o estudo. As intervenções da equipe de Enfermagem devem ser direcionadas aos cuidados assistenciais ao paciente envolvendo ações que variam desde uma avaliação do indivíduo, como a realização de atividades direcionadas ao treinamento da fala, marcha, avaliação do hábito miccional, avaliação da higiene oral e assistência direcionada ao posicionamento correto do paciente, além da avaliação dos riscos de quedas e prevenção de um novo AVC. Diante disso, é necessário que o enfermeiro esteja apto a desenvolver um plano de cuidados voltado para a reabilitação do paciente, sendo necessária a integração de uma equipe multidisciplinar, promovendo assim, um cuidado humanizado e integral.
Bullying nas Instituições de Ensino Superior: Revisão Sistemática / Bullying in Higher Education Institutions: Systematic Review
Authors: Gadelha Maria do Socorro Vieira , Santos Ranyelson Lucas Matias , Ferreira Maria Eduarda Do Nascimento , Costa Diego Oliveira , Araújo Maria Luana , Roque Joaquim Iarley Brito
Published: March 2019

O fenômeno bullying é caracterizado como uma forma de violência a um indivíduo mais fraco ou em desvantagem em relação ao agressor de forma repetitiva ou crônica. Foi realizada uma pesquisa de revisão sistemática abordando o bullying no contexto universitário, utilizando os descritores “bullying” e “universities”, no período de 2009 a 2018. Selecionou-se artigos científicos mediante pesquisa eletrônica indexados em bases de dados como Literatura Latino-Americana e do Caribe em Ciências da Saúde, Medical Literature Analysis and Retrieval System Online, Education Resources Information Center, Periódicos Eletrônicos de Psicologia, Scientific Electronic Library Online, Serviço da Biblioteca Nacional de Medina dos Estados Unidos para acesso gratuito ao Medline. Foram selecionadas 769 publicações científicas, entretanto apenas 54 delas apresentavam os critérios de inclusão na pesquisa. Geralmente, as vítimas do bullying possuem traços diferenciados de orientação sexual e/ou identidade de gênero, sofrem de violência psicológica, passando por situações de humilhação e perseguição. O comportamento das pessoas que promovem o bullying violam os direitos do ofendido, incidindo em dano moral e favorecendo as vítimas a requererem judicialmente seu devido ressarcimento.
Gestão Ambiental nas Universidades Públicas Federais: A Apropriação do Conceito de Desenvolvimento Sustentável a Partir da Agenda Ambiental na Administração Pública (A3P) / Environmental Management in the Federal Public Universities: The Appropriation of the Concept of Sustainable Development from the Environmental Agenda in Public Administration (A3P)
Authors: Batista Agleilson Souto , De Moraes Ionete Cavalcante , Albuquerque José De Lima , Correia Neto Jorge Da Silva
Published: March 2019

Refletir sobre desenvolvimento sustentável, Agenda 21 global, Agenda 21 brasileira e Agenda Ambiental da Administração Pública (A3P) é indispensável no contexto atual da administração pública brasileira, e em especial para as Universidades Públicas Federais. O setor público, como um todo, está passando por um processo de adesão à A3P, mas a sustentabilidade não pode ficar apenas nos discursos políticos, precisa permear as ações governamentais. Nesse estudo, foi feito um recorte para delinear a evolução da adesão dos órgãos públicos à A3P, em especial pelas universidades federais. Acredita-se que a discussão sobre as definições aqui apresentadas e o levantamento acerca do tema em recorte possam auxiliar nas futuras atuações e proposições de Políticas Públicas com foco no Desenvolvimento Sustentável.
Sarcoma Primário de Pulmão: um Desafio a Clínica / Primary Lung Sarcoma: A Clinical Challenge
Authors: Nascimento Caio Andrade , Medeiros Maria Clara Rodrigues Lima , Moraes Laysa Andrade Almeida , Araújo José Klerton Luz , Silva Igor Marcelo Castro e
Published: March 2019

Os sarcomas primários do pulmão são entidades nosológicas raras, representando 0,1% de todas as neoplasias pulmonares malignas. Relatamos o caso de um paciente masculino, tabagista, com diagnóstico de leiomiossarcoma primário de pulmão (LPP), originado no brônquio em fase avançada da doença.
Redução e Mitigação de Impactos Ambientais: Desafios e Oportunidades para o Tratamento e Reuso de Água em um Matadouro de Bovinos
Authors: Silva Karina Melo da , Sousa Josiano Cesar de , Sousa Francielle Rossato de
Published: March 2019

A conscientização para redução e mitigação de impactos ambientais vem ganhando destaque ao longo do tempo. Ações no âmbito público e privado que induzem ao consumo consciente e preservação ou reuso da água crescem a cada dia. Com o objetivo de analisar desafios e oportunidades para o tratamento e reuso da água na atividade frigorífica, o presente artigo foi elaborado utilizando-se da metodologia de estudo de caso, tendo como objeto de estudo um matadouro de bovinos. Como resultado, observou-se que é possível diminuir o consumo de água no matadouro em diferentes etapas, como também é possível que seja reaproveitada a água que é gasta em atividades secundárias, diminuindo o consumo de água potável. A principal contribuição deste artigo foi constatar que o reuso da água pode contribuir para tornar a atividade desenvolvida pela empresa “mais limpa” e ecologicamente sustentável. Mitigação. Impactos ambientais. Matadouro. Reuso de água.
A Educação Ambiental nos anos Iniciais do Ensino Fundamental / Environmental Education in the Early Years of Elementary Education
Authors: Viana Elaine Cristina Da Silva , Oliveira Júnior Geraldo Martins de , Sobral Elayne Cristina Luz Menezes Novaes Cecílio , Sobral Stevens Emanuel Cecílio , Lima Otoniel Moreira Leite
Published: March 2019

A Educação Ambiental exerce um papel importantíssimo na contemporaneidade, uma vez que as ações ao meio ambiente, principalmente as antrópicas, tem aumentado consideravelmente no decorrer dos anos. Este trabalho objetivou analisar o ensino da Educação Ambiental em uma instituição, especificamente no fundamental. A metodologia utilizada foi qualitativa. Os dados foram coletados através de entrevista semiestruturada realizada com discentes que cursam 6º e 7º ano, totalizando 50 entrevistados. Todos alunos da escola Municipal Francisco Filgueira Sampaio, em Serrita, Pernambuco. Os resultados demonstraram que os discentes conhecem o conceito de Educação Ambiental, e compreendem que grande parte das ações causadas à natureza partem do homem. Verificou-se que a educação ambiental é trabalhada principalmente nas disciplinas de Ciências e Geografias (55% e 40%, respectivamente). Quanto ao interesse por assuntos relacionados ao Meio Ambiente, 52% tem interesse razoável. Os entrevistados apontaram a necessidade de mais trabalhos relacionados a temática. Constatou-se que a Educação Ambiental é consideravelmente trabalhada com os discentes,  porém o interesse pelo assunto ainda é razoavelmente considerado, visto que a metodologia aplicada não estimula-os a prática de ações intervencionistas diretas no meio ambiente, considerando a realidade em que vivem.
Auditoria Operacional: Operação Técnica do Aterro Sanitário do Município de Maceió / Operational Auditing: Technical Operation of the Landfill of the Municipality of Maceió
Authors: Vasconcelos Bergson De Mendonça , Baía Amândio Pereira
Published: March 2019

A Auditoria Operacional é um instrumento de controle externo adotado pelo Tribunal de Contas, e tem o objetivo de contribuir para a melhor gestão dos recursos públicos aplicados e destinados a melhoria da qualidade de vida da população, minimizando falhas que penalizam toda uma coletividade. Surge então a necessidade de gerenciar estes procedimentos utilizando como ferramenta a fiscalização, o que permite a apuração de todos os aspectos de uma ação ou programa governamental, desde sua concepção até os resultados efetivos que eles trouxeram à sociedade. Assim, o presente trabalho pretendeu desenvolver um estudo da Auditoria Operacional, relativo à Operação Técnica do Aterro Sanitário do Município de Maceió no Estado de Alagoas, nos anos de 2010, e 2014 – 2016, foram analisadas às células domiciliares (espalhamento, a compactação e a cobertura com argila dos resíduos sólidos, o chorume gerado pelos resíduos na célula que devem ser captados através de drenos e direcionados para a Estação de Tratamento); as podas e compostagem; a estação de beneficiamento de entulhos; os taludes; e a estação de tratamento do percolado, com a finalidade de pontuar os achados (pontos a serem corrigidos) e explicitar as devidas recomendações.
A Evolução Conceitual do Goodwill segundo as Teorias do Intangível, Resíduos, Sinergia e Superlucro
Authors: Galindo Jessica Fernanda , Lima Filho Raimundo Nonato , Soares Sandro Vieira
Published: March 2019

A mudança contínua na sua estrutura e as múltiplas alterações no desenvolvimento do tratamento contábil, com um crescimento rápido e significativo entre todos os outros ativos intangíveis são fatores que justificam o interesse em se pesquisar sobre o goodwill, uma vez que, apesar de ser um tema bastante discutido, ainda permanece em ampla discussão. Assim, este estudo apresenta a evolução conceitual a partir das definições desenvolvidas por estudiosos ao longo das últimas décadas, publicadas em revistas e livros disponíveis em bases e indexadores internacionais e/ou nacionais de Contabilidade. Nesse contexto, o objetivo desta revisão de literatura foi analisar a evolução do conceito goodwilla partir das teorias: intangível, resíduos, sinergia e superlucro, oferecendo uma visão geral das suas definições, para entendê-lo através dos conceitos mencionados por acadêmicos e organismos profissionais de Contabilidade. Esta pesquisa é o resultado de uma análise qualitativa cronológica do conceito de goodwill, trazendo definições existentes datadas a partir de 1897, com os efeitos nas demonstrações contábeis que estão associadas às atividades empresariais, fazendo com que seja de extrema importância para a tomada de decisão.
Política Educacional do PROJOVEM Urbano: Uma Revisão Bibliográfica em Relação à Invisibilidade Social / Urban PROJOVEM's Educational Policy: A Bibliographic Review Concerning the Social Invisibility
Authors: Alencar Cláudio , Rocha Lima Murilo Campos
Published: March 2019

O presente artigo tem como principal objetivo de discutir e analisar sobre o programa Projovem Urbano, refletindo sobre as questões do preconceito e da invisibilidade social através da metodologia de classe qualitativa, sendo constituída a partir de uma pesquisa e revisão bibliográfica que subsidiou a coleta de dados primários, a partir de livros, revistas, sites e outros tipos. Fazendo uma análise textual sobre os principais pontos a serem abordados deste a estrutura do Programa Projovem até as Políticas Públicas que envolvem os direitos da educação e da cidadania. Demonstrando a ligação da Politica Pública Educacional com o Projovem Urbano na dinâmica do seu público-alvo na questão da invisibilidade social.
A Lei Complementar nº 131/2009 (Lei da Transparência) e a Gestão Pública / The Complementary Law 131/2009 (Transparency Law) and Public Management
Authors: Bezerra Letícia Lauany Gomes , Ramos Júlio Cezar Costa
Published: March 2019

Com o avanço da globalização, o Setor Público vem sofrendo mudanças, sendo uma delas a Lei de Responsabilidade Fiscal nª 101 de 2000. Esta tem objetivos voltados para a responsabilidade e transparência do setor, bem como a Lei da Transparência nº 131 de 2009, que evidencia a divulgação dos dados públicos por meio do portal da transparência.  No presente trabalho buscou-se analisar a gestão pública no município de Araripina, sertão de Pernambuco, sobre a evolução da transparência na gestão pública.  A pesquisa além de descritiva envolve a legislação e instrumentos da tecnologia da informação relacionados a publicidade das informações da gestão municipal. Os resultados evidenciam que ainda é preciso avançar nos mecanismos contra a corrupção, já que não bastam a existência de leis que obriguem a gestão pública a trabalhar de forma ética e idônea. É necessário uma mudança de paradigmas nos cidadãos. evitando-se os interesses pessoais.