bluuebunny/crossref_metadata_2025 huggingface dataset:
AMPK and TBC1D1 Regulate Muscle Glucose Uptake After, but Not During, Exercise and Contraction
Authors: Kjøbsted Rasmus , Roll Julie L.W. , Jørgensen Nicolas O. , Birk Jesper B. , Foretz Marc , Viollet Benoit , Chadt Alexandra , Al-Hasani Hadi , Wojtaszewski Jørgen F.P.
Published: April 2019

Exercise increases glucose uptake in skeletal muscle independently of insulin signaling. This makes exercise an effective stimulus to increase glucose uptake in insulin-resistant skeletal muscle. AMPK has been suggested to regulate muscle glucose uptake during exercise/contraction, but findings from studies of various AMPK transgenic animals have not reached consensus on this matter. Comparing methods used in these studies reveals a hitherto unappreciated difference between those studies reporting a role of AMPK and those that do not. This led us to test the hypothesis that AMPK and downstream target TBC1D1 are involved in regulating muscle glucose uptake in the immediate period after exercise/contraction but not during exercise/contraction. Here we demonstrate that glucose uptake during exercise/contraction was not compromised in AMPK-deficient skeletal muscle, whereas reversal of glucose uptake toward resting levels after exercise/contraction was markedly faster in AMPK-deficient muscle compared with wild-type muscle. Moreover, muscle glucose uptake after contraction was positively associated with phosphorylation of TBC1D1, and skeletal muscle from TBC1D1-deficient mice displayed impaired glucose uptake after contraction. These findings reconcile previous observed discrepancies and redefine the role of AMPK activation during exercise/contraction as being important for maintaining glucose permeability in skeletal muscle in the period after, but not during, exercise/contraction.
Closed-loop gap bridging control for remote laser welding of aluminum components based on first principle energy and mass balance
Authors: Franciosa Pasquale , Serino Armando , Botros Rehab Al , Ceglarek Darek
Published: April 2019

Remote laser welding (RLW) has been successfully deployed for steel products, particularly doors, closures, and hang-on parts with overlap seam welding configurations. The growing demand for light-weight body structures has created interesting opportunities to apply RLW to fillet welding with the application to aluminum components. However, seamless migration from seam welding of steel to fillet welding of aluminum is limited by the following challenges: weld seam tracking capability to compensate trim edge variations; hot cracking resulting from the interaction between material chemistry and heat dissipation; and form error variations leading to unwanted part-to-part gaps, which in the absence of filling material must be bridged only by autogenous material. This paper focuses on the aspect of the part-to-part gap bridging and proposes a model to select and adjust welding process parameters to control the volume of the molten pool and achieve gap bridging. The proposed model is based on the observation that gap bridging is impaired by five distinct failure modes. Each mode is modeled by first-principle energy and mass balance criteria. Selection of welding parameters is presented by a set of gap bridging capability charts which helps to prevent failure modes and select feasible weld process parameters.
Hyperspectral and thermal temperature estimation during laser cladding
Authors: Lison Margot , Devesse Wim , de Baere Dieter , Hinderdael Michaël , Guillaume Patrick
Published: April 2019

Although there is no doubt about the tremendous industrial potential of metal additive manufacturing techniques such as laser metal deposition, the technology still has some intrinsic quality challenges to overcome before reaching its industrial maturity. Noncontact in situ monitoring of the temperature evolution of the workpiece could provide the necessary information to implement an automated closed-loop process control system and optimize the manufacturing process, providing a robust solution to these issues. However, measuring absolute temperatures is not self-evident: wavelength-dependent emissivity values vary between solid, liquid, and mushy metallic regions, requiring spectral information and dedicated postprocessing to relate the amount of emitted infrared radiation to the material temperature. This paper compares the temperature estimation results obtained from a visible and near-infrared hyperspectral line camera and a conventional short-wave infrared (SWIR) thermal camera during the laser melting and cladding of a 316L steel sample. Both methods show agreeing results for the temperature distribution inside the melt pool, with the SWIR camera extending the temperature measurements beyond the melt pool boundaries into the solid region.
PENGGUNAAN ATRAKTAN DAUN TALAS (Colocasia esculenta) DENGAN VARIASI PESTISIDA NABATI TERHADAP POPULASI KEONG MAS Pomacea canaliculata Lamarck (Mollusca : Ampullariidae) PADA PADI DI SUMATERA UTARA
Authors: Nadeak Vorly Junesna , Siregar Ameilia Zuliyanti
Published: April 2019

Keong mas (Pomacea canaliculata Lamarck) merupakan salah satu hama utama pada tanaman padi yang sampai saat ini belum dapat dikendalikan dengan baik dengan perkembangbiakan sangat cepat. Pengendalian dengan moluskisida kimia meninggalkan residu lingkungan, sehingga dicari alternatif pengendalian yang ramah lingkungan menggunakan kombinasi atraktan. Penelitian ini bertujuan untuk mendapatkan tanaman yang efektif sebagai pestisida nabati yang dapat digunakan untuk mengendalikan keong mas di lapangan. Penelitian ini dilaksanakan pada bulan April sampai Mei 2017 di Susuk VIII, Padang Bulan, Medan Selayang.  Metode yang digunakan adalah rancangan acak lengkap non faktorial dengan 6 perlakuan dan 4 ulangan yaitu (kontrol), serbuk pinang (Areca catechu), serbuk serai (Cymbopogon citrates), serbuk daun sukun (Artocarpus altilis), serbuk mengkudu (Morinda citrifolia), dan serbuk eceng gondok (Eichhornia crassipes). Hasil penelitian menunjukkan serbuk pinang (Areca catechu) paling efektif mengontrol mortalitas keong mas pada hari ke-7 (100%). Perhitungan persentase rumpun padi yang terserang keong mas terendah pada perlakuan serbuk pinang dengan rata-rata  adalah 0,062 pada waktu kematian 2 hari setelah aplikasi. Hasil penelitian menunjukkan kelima serbuk pestisida nabati ini dapat mengendalikan keong mas pada tanaman padi di Sumatera Utara.
ANALISIS MUTU KIMIA DAN ORGANOLEPTIK PUPUK ORGANIK TANDAN KOSONG KELAPA SAWIT DENGAN DOSIS EM-4 BERBEDA
Authors: Mustika Ade Maya , Suryani Penti , Aulawi Tahrir
Published: April 2019

This research was conducted from August to December 2016 at the PEM Laboratory of the Faculty of Agriculture and Animal Sciences State Islamic University of Sultan Syarif Kasim Riau and Central Plantation Service Laboratory. The study aims to 1). Analyzing the chemical and organoleptic qualites of Oil Palm Empty Bunches organic fertilizer with the addition of different EM-4 doses 2). Determine the best quality on the quality of Oil Palm Empty Bunches organic fertilizer. The experimental design was Completely Randomized Design (CRD) and three replications. The treatment were application of (EM4) consist of 0 ml, 5 ml, 10 ml, 15 ml, 20 ml, and 25 ml. Results analysis using ANOVA variance, simple linear regression and validity and reliability analysis. The results showed that the addition of EM-4 resulted in quality in accordance with SNI 19-7030-2004 with the dose of 5 ml, 10 ml, and 15 ml, respectively, but on the measurement of fertilizer pH organic Oil Palm Empty Bunches does not meet SNI: 19-7030-2004.
SIFAT KIMIA TANAH DAN PRODUKTIVITAS KELAPA SAWIT (Elaeis guineensis Jacq.) PADA TINGGI MUKA AIR TANAH YANG BERBEDA DI LAHAN GAMBUT
Authors: Wawan Wawan , Ariani Erlida , Lubis Heru Rahmatsyah
Published: April 2019

The aims of this study to be determine the soil chemical properties and productivity of oil palm (Elaeis guineensis Jacq.) at different water levels on peatlands. The research was carried out in PT. Tabung Haji Indo Plantation (PT. THIP) Indragiri Hilir and the analys of soil chemical properties were conducted at the Laboratory of Soil Science, Faculty of Agriculture, Universitas Riau, Tampan District, Pekanbaru. This research was held started July to October 2017. This research conducted used survey method. The sampling location in this research are divided into 3 strata in 3 difference blocks and 3 samples that had been determined are named: TMA1 = 20- 40 cm, TMA2 = 41-60 cm and TMA3 => 60 cm carried out experimental used completely randomized design (CRD). There are three times repeatation treatments and 27 samples units in total. The observation data that obtained are analyzed statistically using analysis of variance (ANOVA). The results of variance analysis were continued by Duncan's multiple range test at the 5% level. The parameters of observation carried out include soil chemical properties: pH, C-organic, N-total, P-total, K-total, cation exchange capacity (CEC), saturation of bases (KB) and productivity of oil palm. The results showed that peatland with a water level of > 60 cm had soil pH, organic C, N-total, P-total, K-total, and CEC was higher than the water level of 20-40 cm and 41-60 cm, while KB at a depth of 20-40 cm had a higher KB value than the water level of 41-60 cm and > 60 cm.
Religious and Cultural Differences and Youth of India in The Novels of Chetan Bhagat
Authors: Tiwari Sapna
Published: April 2019

“Chetan Bhagat” is the writer of five bestselling novels in Indian writing in English. He is the writer of young generation and he has raised problems of youth through his novels.This paper attempts the differences of the various cultures and different religion existing in India being portrayed in his novels. The research shows the actual picture of the society where vividness and then unity has come up in a shape.
HRM Practices & Organizational Culture Have Positive Impact : A Study of Few Selected Organisations
Authors: Chaturvedi Dr. Rachna
Published: April 2019

HR has an important role of play in Organisational Culture, as it is the people who work for the organization, who embrace and develop a particular culture within the organization, any desired changes to the culture of the organization has been made through the people and by the people. HR provides the organization with effective means of facilitating an organizational culture. The present study focuses on the positive significant relationship between HRM practices and organizational culture in few private sector organizations. There is a positive significant relationship between HRM practices and variables of organizational culture operationalised in terms of self-realization, status enhancement, inventive values and social economic support.
The Key Criminal Economic Policies towards Real Estate Turnover
Authors:   Ural State Law University, Dryga Vasily Alekseevich
Published: April 2019

The study looks at the key criminal economic poli-cies on real estate turnover, their development and objectives. The analysis of current legislation and relevant statistical data demonstrates that there is an ineffective anti-criminal mechanism in this field in Russia. The research examines the urgent issues related to economic security; the procedure of real estate turnover; the protection of property rights; the protection of the rights and freedoms of citi-zens, legal entities, and public authorities from ille-gal real estate turnover and crime that leads to such violations. The paper describes the strategic and tactical foundations of criminal economic policy as a tool to counter real estate crime. The terms ‘strategy’ and ‘tactics’ are defined as well. It is argued that interdepartmental communication should be estab-lished among state agencies responsible for real estate accounting and distribution by creating a single database. A ban on modifying data in state electronic systems by restricting access to them can be treated as a preventive measure in this regard. While developing the basic criminal economic poli-cies, one should have expertise in real estate turno-ver and realize the nature of real estate, its regulato-ry mechanisms and functioning.
Crime Scene Technician Workstation: Requirements and Modern Solutions
Authors:   Volgograd Academy of  the Ministry of Internal Affairs of  the Russian Federation, Duseva Nina Yurievna
Published: April 2019

The study looks at the fact that modern technology facilitates the detection and investigation of crimes and discusses the prerequisites for introducing modern technical developments and information technology into expert activities to investigate ele-ments subject to examination and improve the work-flow of highly specialized staff. Based on forensic literature, the author analyzes the concept of work-station and defines the characteristics, advantages, principles, and arrangements of a crime scene tech-nician workstation. The relevant requirements should be fulfilled. In particular, it is necessary to provide a high level of information security and pro-tect against unauthorized access to system data-bases designed to automate expert activities and increase their efficiency. In the author’s opinion, in addition to the considerable importance of equip-ment and technology that help develop professional skills, the full-fledged information support for work-stations plays a great role in performing the tasks assigned to crime scene technicians. Software and hardware systems necessary for traditional examina-tions are exemplified. The emphasis is placed on the need to train qualified staff capable of using the developments under discussion.
The Social and Economic Characteristics of Municipality in the Context of the Theory of Sustainable Development
Authors:   Nizhnevartovsk branch of  Southern Ural State National Research University, Morozkov Vladimir Anatolyevich , Prokopyeva Tatyana Vladimirovna ,   Nizhnevartovsk branch of  Southern Ural State National Research University, Prokopyev Alexander Vladimirovich ,   Nizhnevartovsk branch of  Southern Ural State National Research University
Published: April 2019

The research analyzes the sustainable development of municipalities in the context of the unstable ex-ternal environment, scarce resources, and innovative trends at the state level. The paper discusses vari-ous approaches to studying the problems of region-al and municipal sustainable development. The au-thors examine relevant international models focused on various economic growth factors and conclude that these models cannot always be applied to the meso-level systems such as municipalities. The study reveals that environmental and location fac-tors with a social and economic potential have a considerable impact on the sustainability of munici-palities. The challenges of sustainable economic and social development of Nizhnevartovsk and Nizhnevartovsky District are described. The recom-mendations are proposed to improve the policy on sustainable development of municipalities.
The Structure of Russian Legislative Process: Its Stages and Steps
Authors:   Taganrog Institute of Management and Economics, Zolotukhina Tatiana Aleksandrovna
Published: April 2019

The research proposes and substantiates the novel approach to classifying the stages of and the steps in the legislative process as a pivotal element of law-making. Having analyzed the current legislation of the Russian Federation, legislative practices and procedures, and studies on this issue, the author describes the pre-parliamentary, parliamentary, and post-parliamentary stages. They can be divided into the following steps: introduction of a bill, discus-sion of a bill, adoption of a law, promulgation of law and coming into force. The research critically exam-ines the divergent views of legal experts on the number and content of the steps in the evolving legislative process and its stages. The author con-cludes that this process should be developed in both theoretical and practical terms based on previ-ous practices in this regard.
Dos décadas de conflicto en torno al uso propio de semillas de soja genéticamente modificada en Argentina: fases del enfrentamiento, acumulación de capital y actores sociales (1996-2018)
Authors: Pérez Trento Nicolás
Published: April 2019

En este trabajo buscaremos analizar el contenido del conflicto suscitado en la Argentina en torno a las semillas de soja genéticamente modificada, que involucró a una multiplicidad de actores sociales. En efecto, si bien el reclamo por el pago de regalías fue liderado por Monsanto, los criaderos de variedades también exigirían lo propio, aliándose con aquélla. Estas pretensiones serían enfrentadas por distintas organizaciones, entre las que destacan la Sociedad Rural Argentina y la Federación Agraria Argentina. Por su parte, también el gobierno kirchnerista enfrentaría estas exigencias, aunque con distinta vehemencia. Tras caracterizar brevemente la dinámica del conflicto, valiéndonos de documentos, notas periodísticas y entrevistas, procuraremos explicar su contenido a partir del análisis de la riqueza social en juego en el contexto de la especificidad que toma la acumulación de capital en la Argentina.
Agricultura a pequeña escala en tierras altas y tierras bajas. Estudio comparativo entre la Quebrada de Humahuaca y el partido de Florencio Varela
Authors: Castro Mora , FABRON Giorgina
Published: April 2019

Se analiza la agricultura de dos áreas de la Argentina unidas por la migración de grupos familiares, desde tierras altas hacia el periurbano bonaerense, indagando en la producción a pequeña escala, en los desafíos metodológicos para caracterizar a la misma y en la transmisión de conocimientos locales. La metodología se basó en el análisis de distintas fuentes censales con trabajo etnográfico. Como resultado se caracterizó a las familias productoras y se logró identificar prácticas y saberes productivos - alimentarios, así como las articulaciones en el cambio de las condiciones socioambientales de los mismos en el territorio migrante. Se concluye que la agricultura a pequeña escala resulta una categoría adecuada para este caso y que las familias migrantes consolidaron en el proceso de migración conocimientos productivos - alimentarios desde la agricultura familiar, lo que posibilita considerar la existencia de un tipo de soberanía alimentaria desde el consumo.
Wavelets Defined Over Non Nested Tetrahedral Grids: A Theoretical Approach
Authors: Boscardin Liliana B. , Castro Silvia M. , Castro Liliana R.
Published: April 2019

The main contribution of this paper is the definition of wavelets over non nested tetrahedral grids, allowing the representation of functions defined on an a irregular tetrahedralization. In this way, it is possible to represent different attributes of a 3D object such as its color, brightness, density, etc. This representation consists of a set of coefficients corresponding to a coarse resolution followed by a set of detail coefficients that measures the error between two successive approximations. In this work the analysis matrix that allows going from a fine to a coarser resolution and the synthesis matrix needed for going from a coarse resolution to a finer one, are presented. All this is within the framework of non nested tetrahedral grids.
A Reference Architecture for Ontology Engineering Web Environments
Authors: Braun German Alejandro , Estevez Elsa , Fillottrani Pablo
Published: April 2019

Ontology authoring, maintenance and use are never easy tasks, mostly due to the complexity of real domains and how they dynamically change as well as different background possessed by modellers about methodologies and formal languages. However, although the needs for ontologies are well-understood, not less important is to provide editing tools to manipulate and understand them. In this context, this work proposes and documents a reference architecture for such tools running in web environments. Moreover, it provides the rationale for boosting the collaborative development of a novel tool based on this architecture, named crowd. Previous surveys reveal that few Web-based ontology engineering environments have been developed and in addition, almost all of them are mere visualisers, with limited graphical features and lacking inference services
Educational Serious Games as a Service: Challenges and Solutions
Authors: Sandí Delgado Juan Carlos , Bazán Patricia
Published: April 2019

Cloud computing is a distributed computing technology that facilitates access to resources in a dynamic and scalable way which is highly available.  One of the service models is SaaS (Software as a Service) which allows executing Web applications flexible and elastically while offering collaborative characteristics. The integration of SaaS in educational environments promotes academic performance and facilitates knowledge management, allowing for storage, exchange, access, and synchronization of information.  On the other hand, serious educational games promote among the people involved: collaboration, communication, social abilities, critical thinking, and problems solving. The present work analyzes the challenges that SaaS, with its collaborative and Multi-Tenant characteristics, offer to the execution of serious educational games, this is named JSEaaS –Serious Educational Games as a Service.  The analysis was developed based on an exhaustive and systematic bibliographic revision with a qualitative methodological focus, which generated investigation questions, search strategies, keywords and inclusion and exclusion criteria that were applied to identify articles in different sources. This work allowed for the development of a list of the functional characteristics that the serious educational games will acquire when used as software as a service.
THE HISTORY OF SURGICAL TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE
Authors: Tarbaev I. S. , Akhmatov A. M. , Vasilevskii D. I. , Rutenburg G. M.
Published: April 2019

The most important historical stages of formation of scientific ideas of gastroesophageal reflux and its complications are presented in the article; the main milestones in the development of gastroesophageal reflux disease surgery are reflected.
A BRIEF HISTORY OF UNIVERSITY CLINICS IN RUSSIA AND IN THE WORLD
Authors: Kochorova L. V. , Potapchuk A. A. , Afanasieva V. V.
Published: April 2019

The article discusses the importance of university clinics and historical aspects of their development both abroad and in Russia. The history of the development of university clinics goes side by side with the development of medical education in general. The concept of university clinics has been laid down since the time of the ancient East. The European stage of the formation of university clinics dates back to the Middle Ages and the Renaissance period. Nowadays, university clinics work according to the model of cooperation between the university and the clinic, or according to the model of integration of the clinic into the university. In Russia, in fact, Peter the First laid the notion of university clinics that facilitated the opening of hospital schools. The importance of combining the educational and therapeutic process is proved. Thus, this combination improves the quality of medical care.
ECONOMIC EFFICIENCY OF THE ORGANIZATION OF THE REHABILITATION CENTER FOR CHILDREN WITH INFECTIOUS DISEASES
Authors: Samoylova I. G.
Published: April 2019

Introduction. Infectious diseases make a significant contribution to the recurrence and disability, and therefore cause economic damage to the country, which is an indisputable argument in favor of the creation of a system of rehabilitation of children with infectious diseases.

The objective of the study was the economic justification of the need to organize a multidisciplinary children’s rehabilitation center, including after infectious diseases. 

Material and methods. Based on the long-term experience of the only center in the Russian Federation for the treatment of children’s infections and the data of the statistical service we calculated the economic effect obtained as a result of reducing the recurrence of infectious diseases and disability caused by them among the child population.

Results. The study found that the annual economic losses associated with the treatment of relapses of infectious diseases among children would be 4.344 billion rubles and 39.713 billion rubles due to the payment of disability benefits. The economic loss associated with the reduction of days of incapacity of parents obliged to care for children who need care due to infectious diseases is 2.791 billion rubles. In addition, the indirect economic loss caused by the under-produced products and the GDP decline due to the disability of such children already in working age is 30.102 billion rubles.

Conclusion. We proved the significant economic effect that would be received at the opening of the rehabilitation center for children. The economic effect is caused by the reduction of both direct and indirect economic losses.
ANALYSIS OF SECONDARY CARE PROVIDED TO TRAUMA VICTIMS WITH THORACIC AND LUMBAR SPINE INJURIES IN A SETTING OF AN URBAN CENTRE FOR ACUTE SPINAL SURGERY
Authors: Dulaev A. K. , Manukovski V. A. , Kutyanov D. I. , Parshin M. S. , Dulaev D. V. , Brizhan S. L. , Iskrovskiy S. V. , Zhelnov P. V.
Published: April 2019

Background.Foundation of specialised centres or units of acute spinal surgery in general acute hospitals is to be considered a tendency of much importance in development of metropolitan systems for management of trauma victims with spinal injuries.

Objective. To analyse size and structure of the patient inflow, contents and outcomes of treatment of trauma victims with thoracic and lumbar spine injuries in a setting of a specialised centre for acute spinal surgery located in a major city in our country.

Material and methods. 1,760 trauma victims with thoracic and lumbar spine injuries admitted to an urban centre for acute spinal surgery of St. Petersburg in 2010 through 2016: 1,204 (68.4%) – isolated neurologically intact, 410 (23.3%) – isolated with spinal cord injury, 146 (8.3%) – spinal injuries in polytraumatised patients. An analysis of health administrative and clinical data was performed using non-parametric statistics.

Results.During the period the centre worked, the number of annually admitted trauma victims increased 3.44 times, while notably, in the annual structure of the inflow, of which a fraction of isolated neurologically intact injuries decreased from 75.4% to 64.5%, there was an increase in fractions of persons with isolated spine and cord injuries (from 20.2 to 25.0%; р=0.2878) and with spinal injuries and polytrauma (from 4.4 to 10.5%; р=0.0718). The surgical rate was observed to increase from 69.3% to 81.9% (р = 0.0036), especially in trauma victims with unstable isolated neurologically intact injuries. In the annual structure of surgical work, a fraction of early procedures constantly increased (from 27.8 to 91.6%; р=0.0001), the increase rate appearing most stable in neurologically intact patients with isolated injuries. The treatment outcomes showed high values by all measures.

Conclusion.The setting of a specialised secondary care centre for acute spinal surgery of a major city delivers high effectiveness and favourable outcomes of treatment of trauma victims with spinal injuries owing to the centralisation of their inflow, broad use of modern medical technology, and the tactic of early surgery.
INTERRELATIONSHIP OF THE MEDIATOR OF ANGIOGENESIS OF VEGF-A WITH GLUTATHIONE METABOLISM PARAMETERS AND THE CLINICAL CHARACTERISTICS OF SYSTEMIC AUTOIMMUNE DISEASES WITH JOINT DAMAGE
Authors: Alexandrova L. A. , Filippova N. A. , Iman A. , Subbotina T. F. , Trofimov V. I.
Published: April 2019

Introduction.In systemic autoimmune diseases with joint damage (SADJD), impaired angiogenesis occurs, which plays a key role in the progression of proliferative synovitis and in the development of lesions of the internal organs. Excessive production of vascular endothelial growth factor VEGF-A, the main mediator of angiogenesis, leads to an increase of the inflammatory process.

The objectiveof the work was to study the relationship of VEGF-A with glutathione metabolism parameters, activity of the process and immune status in systemic autoimmune diseases with joint damage.

Material and methods.58 patients with systemic autoimmune diseases with joint damage were examined. The comparison group consisted of 45 healthy individuals. The main clinical parameters and rheumatoid factor (RF) were analyzed. To determine the activity of the process, we calculated the indices DAS28 for patients with rheumatoid arthritis (RA) and BASDAI for patients with ankylosing spondylarthritis (AS). The activities of the enzymes glutathione peroxidase (GPO), glutathione reductase (GR), superoxide dismutase (SOD) and the content of GSH were determined in erythrocytes.

Results. The level of serum VEGF-A in patients with systemic autoimmune diseases with joint damage was increased more than 30 %, in erythrocytes the concentration of GSH and GPO activity were 2 times lower and almost 2 times lower respectively, and GR activity was reduced by about 20 % compared with donors. A correlation was found between the level of VEGF-A and GR activity (R = 0.579; P = 0.03) in RA patients with moderate activity of the process, and absence of relationship between these parameters and the activity of the process in AS. The activity of both GPO and GR in patients with RF was lower by more than 1.5 times, and SOD activity was twice lower than control. The VEGF-A level in the blood plasma was determined by the method of non-competitive enzyme immunoassay.

Conclusion.The increase in VEGF-A level in the blood plasma of patients with systemic autoimmune diseases with joint damage is most pronounced in RA patients with moderate activity of the process and is associated with the presence of RF. The relationship of VEGF-A and GR activity indicates a special role for this enzyme in the regulation of angiogenesis in RA.
TO THE 160TH ANNIVERSARY OF THE BIRTH OF SERGEI IAKOVLEVICH KULNEV
Authors: Krasnoselskikh T. V. , Sokolovskii E. V.
Published: April 2019

Professor Sergei Iakovlevich Kulnev, student and follower of the founder of the Russian syphilidology Veniamin Mikhailovich Tarnovsky, was the head of the Department of Skin and Venereal Diseases at St. Petersburg Medical Institute for Women in the difficult years of its formation – from 1903 to 1924. In fact, the merit of establishing the Department with clinic in the newly formed educational institution for women belongs to him. In 1913, with the active participation of S.Ia. Kulnev, the separate building for the Department of Skin and Venereal Diseases was built, and to this day, it is still located at this premise. Also, for almost a quarter of a century (from 1901 to 1924) S.Ia. Kulnev was the chief physician of the Kalinkinsky Hospital, the oldest specialized dermatological and venereal hospital in Russia and in Europe, where, in fact, Russian syphilidology was born.

In Soviet times, the merits of S.Ia. Kulnev who was an actual state councillor and representative of the famous noble Russian family, as an organizer of the Department with Clinic of Skin and Venereal Diseases, was undeservedly ignored.His activity appeared to be in the shadow of achievements of his brightest students, graduates of Medical Institute for Women A. A. Sakhnovskaia and O.N. Podvysotskaia, who alternately headed the Department after the death of Sergei Iakovlevich.

The objective of the article, dedicated to the 160th anniversary of the birth of Professor Kulnev, was the desire to pay tribute to the memory of a remarkable physician, teacher and man, whose whole life was devoted to the development of Dermatovenereology and the organization of women’s medical education in Russia. The property of S. Ia. Kulnev is not only a thing of the past. His works laid the foundation of today’s educational, scientific and medical activities of the Dermatovenereology Department of Pavlov First St. Petersburg State Medical University.
The Evaluation of Lecturer's Performance and Sekolah Tinggi Perikanan's Performance Through Intellectual Capital
Authors: Aida VitayalaS. Hubeis Mextaria Yuliana, Anggraini Sukmawati,
Published: April 2019

Intellectual capital is an intangible resource owned by the organization that can be used to create value for the organization. Intellectual capital consists of the source of human capital, the organization itself and its relationship to the environment. The purpose of this research is to analyze the effect of intellectual capital on lecturer and organizational performance and the effect of lecturer performance on organizational performance. Lecturer performance was measured by Key Performance Indicator value. Organizational performance was measured by perspective of costumer, finance, internal business process, learning and growth. Respondents of this research were 106 lecturers in Sekolah Tinggi Perikanan. Data was analyzed by descriptive analysis and Structural Equation Modeling (SEM) with LISREL. The results showed that intellectual capital has positive effect and significant on lecturer and organizational performance. Lecturer performance has positive effect on organizational performance, but insignificant. University is the organization which high intellectual capital, so organization could be able to manage them for improving performance.
Tim Brady: Music for Large Ensemble (CD Review)
Authors: Boyd Alastair
Published: April 2019

[no abstract]
Perbandingan Ketahanan Gempa SNI 03-1726-2002 & SNI 03-1726-2012 Pada Perencanaan Bangunan Gedung Di Kota Aceh
Authors: Hastono Budi , Syamsudin Ryan
Published: April 2019

Sejarah pedoman perencanaan struktur beton bertulang untuk bangunan gedung di Indonesia terus berkembang, yang pertama PBI’ 71, kemudian diperbarui SK-SNI T-15-1991-03, diperbaruhi SNI 03-2847-2002. Pada saat ini telah diterbitkan pedoman edisi terbaru yaitu SNI 03-2847-2013. Untuk pedoman perencanaan ketahanan gempa juga mengalami pembaharuan, yang telah lama digunakan adalah SNI 03-1726-2002, dan untuk saat ini telah juga terbit edisi terbaru SNI 03-1726-2012. Terkait dengan perkembangan pedoman perencaaan tersebut tentunya terdapat beberapa perubahan-perubahan atau penyederhanaan dalam perencanaan yang perlu untuk diketahui, khususnya yang terjadi pada ketahan gempa. Metode perencanaan diaplikasikan pada bangunan gedung 3 lantai yang terdapat di kota aceh dengan sistem Struktur Rangka Pemikul Momen Khusus (SRPMK) berpedoman pada SNI 03-2847-2013, untuk perencanaan ketahanan gempa dengan menggunakan 2 pedoman yaitu SNI 03-1726-2002 dan SNI 03-1726-2012. Pedoman SNI 03-1726-2002 menghasilkan faktor percepatan respon (C) gempa maksimum 0.83 terjadi pada waktu getar alami 0,2 detik dan beban gaya geser static ekuivalen akibat pengaruh gempa rencana (V) 10.518 kgf pada arah X dan 19.515 kgf pada arah Y. Pedoman SNI 03-1726-2012 menghasilkan faktor percepatan respon (SA) gempa maksimum 0.9 terjadi pada waktu getar alami 0,143 detik dan beban gaya geser static ekuivalen akibat pengaruh gempa rencana (V) 12,129 kgf pada arah X dan 22,483 kgf pada arah Y. Hasil perbandingan perhitungannya adalah nilai respon spektrum SNI 03-1726-2012 lebih besar 8,5 % dari SNI 03-1726-2002 dan untuk statik ekuivalen SNI 2012 lebih besar 14 % dari SNI 2002, sehingga berpengaruh momen yang bekerja pada balok yang menyebabkan perbedaan dimensi dan kebutuhan tulangannya, dan dari hasil perhitungannya SNI 2012 lebih besar 3% dari SNI 2002 namun pada gaya aksial yang bekerja pada kolom dan pondasi nilainya sama pada masing-masing sni, sehingga design dan perhitungannya sama.
Pengaruh Variasi Komposisi Campuran Mortar Terhadap Kuat Tekan
Authors: Zuraidah Safrin , Hastono Budi
Published: April 2019

Di Indonesia khususnya penggunaan mortar sudah sangat populer. Dimana dalam membangun sebuah konstruksi beton, mortar selalu digunakan sebagai bagian dari sebuah konstruksi. Tetapi proses pembuatan campuran mortar terkadang masyarakat kurang benar dalam membuat campuran jika ditinjau dari segi ekonomis dan kualitasnya. Berdasarkan uraian tersebut, maka penulis tertarik untuk mengadakan penelitian pengaruh variasi komposisi campuran mortar terhadap kuat tekan, dengan dua sampel jenis semen. Mortar menggunakan mortar dari Semen Gresik dan dari Semen Holcim tanpa bahan tambahan lain. penelitian menunjukan bahwa semakin bertambahnya komposisi pasir  maka kuat tekan mortar semakin menurun. Dimana kuat tekan mortar pada umur 28 hari untuk variasi komposisi campuran dengan menggunakan Semen Gresik  1:4 sebesar 9,5 Mpa; 1:5 sebesar 11,68 Mpa; 1:6 sebesar 7,86 Mpa dan 1:7 sebesar 5,31.sedangkan nilai kuat tekan untuk mortar yang menggunakan Semen Holcim berturut sebesar 13,38 Mpa; 12,95 Mpa; 7,65 Mpa dan 3,19 Mpa. Hasil resapan air pada mortar dengan menambahkan jumlah pasir akan mengakibatkan semakin besar nilai penurunan kuat tekan masing –masing variasi mortar.Sehingga campuran plesteran dinding atau spesi untuk merekatkan keramik lantai dan dinding bangunan sederhana mortar yang direkomendasikan adalah komposisi campuran dengan perbandingan semen:pasir 1:5 untuk Semen Gresik dan 1:4 dan 1:5 untuk Semen Holcim.
Kajian Tingkat Kerusakan Menggunakan Metode PCI Pada Ruas Jalan Ir. Sutami Kota Probolinggo
Authors: Hidayat Samsul Rian , Santosa Rudy
Published: April 2019

Jalan merupakan prasarana penting dalam transportasi yang dapat berpengaruh terhadap kemajuan bidang ekonomi, sosial, budaya maupun politik di suatu wilayah. Namun umur jalan yang sudah direncanakan pada kenyataannya tidak sesuai dengan yang terjadi di lapangan. Tujuan dari penelitian ini adalah untuk menilai kondisi perkerasan Jalan Ir. Sutami Kecamatan Wonoasih Kota Probolinggo. Metode yang digunakan dalam penelitian ini yaitu metode PCI (Pavement Condition Index). PCI (Pavement Condition Index) adalah sistem penilaian kondisi perkerasan jalan berdasarkan jenis, tingkat dan luas kerusakan yang terjadi, dan dapat digunakan sebagai acuan dalam usaha pemeliharaan. Jalan Ir. Sutami Kecamatan Wonoasih Kota Probolinggo dengan panjang 2.4 km dibagi menjadi beberapa segmen dengan ukuran 200 x 7 m per segmennya. Masing-masing segmen di evaluasi dengan mengukur dimensi, identifikasi jenis dan tingkatan kerusakannya untuk mendapatkan nilai PCI. Hasil Penelitian Menunjukkan terdapat 7 macam kerusakan yang terjadi pada ruas Jalan Ir. Sutami Kecamatan Wonoasih Kota Probolinggo. Jenis kerusakannya adalah Alur (Rutting) sebesar 50,03%, Tambalan (Patching) sebesar 26,34%, Retak Kulit Buaya (Alligator Cracking) sebesar 20,37%, Pelapukan dan Butitran Lepas (Weathering and Raveling) sebesar 2,2%, Persilangan Jalan Rel (Railroad Crossing) sebesar 0,69%, Lubang (Pothole) sebesar 0,17%, dan yang terakhir Amblas (Depression) sebesar 0,02%. Nilai rata – rata PCI sebesar 51,5 yang menunjukkan kondisi perkerasan jalan dalam kondisi Sedang/Fair, sehingga perlu suatu penanganan serius dari pemerintah untuk segera melakukan perbaikan sebelum kerusakan menjadi lebih parah.
Optimalisasi Profil Baja IWF Pada Konstruksi Bangunan Parkir Sepeda Motor 4 Lantai (Studi Kasus Gedung Spazio Tower 2, Surabaya)
Authors: Santina Azmi Cindi , Zuraidah Safrin , Hastono Budi
Published: April 2019

Keterbatasan lahan merupakan penyebab pembangunan pada saat ini dibangun vertikal, begitu pula dengan pembangunan tempat parkir sepeda motor lantai 4 gedung Spazio Tower 2 dengan menggunakan struktur baja. Namun pembangunan tersebut dirasa belum optimal, sehingga perlu direncanakan ulang pemilihan profil baja IWF yang paling optimal pada struktur portal (balok dan kolom) serta tetap dapat menahan beban-beban dalam yang terjadi.Dalam pengoptimalisasian ini perhitungan mengacu pada Spesifikasi untuk Banguna Gedung Baja Struktural (SNI 1729:2015), dan pembebanan mengacu pada Pedoman Perencanaan Pembebanan untuk Rumah dan Gedung  (PPURG 1987) serta pembebanan gempa mengacu pada Standar Perencanaan Ketahanan Gempa untuk Struktur Bangunan Gedung  (SNI 1726-2002) dengan menggunankan permodelan 2D pada analisis struktur menggunakan SAP2000.Berdasarkan hasil analisis struktur dan perencanaan ulang profil baru pada struktur portal pembangunan tempat parkir sepeda motor 4 lantai dihasilkan profil IWF yang optimal untuk komponen balok memanjang menggunakan  IWF 400 x 200 x 7 x 11, komponen balok melintang  menggunakan IWF 350 x 175 x 6 x 9 dan pada kolom baik memanjang maupun melintang menggunakan IWF 350 x 350 x 10 x 16. Dengan presentase pengurangan pada dimensi sebesar 33% dari eksisting, 45,1 % pada momen nominal terfaktor dan 2,1% pada kuat tekan nominal dibandingkan kondisi eksisting.
Kajian Analisis Lalulintas Simpang Bersinyal di By Pass Krian Untuk Perencanaan Pelebaran Jalan dan Fly Over
Authors: Wibisono R. Endro , Muhtadi Adhi , Cahyono Donny
Published: April 2019

Krian Bypass intersection is a very crowded route because of its location near Sidoarjo and Mojokerto Regencies for the economic distribution of Surabaya City. There needs to be phase regulation, road widening or fly over so that the intersection traffic volume is not getting saturated. As a benchmark is the forecasting of traffic performance carried out for 3 years from 2018 to 2021. Based on the results of forecasting, the Krian Bypass intersection will decrease its DS value by widening the road so that the green time cycle will be low and turn right impact the DS value below 1 (one). The lowest 2018 DS is 1.61, while the highest DS is 2.49. While the lowest year 2021 DS is 2.72, while the highest DS is 4.85. For the solution with the right turn phase for each intersection to the north DS = 1.02, U-RT = 0.82, S = 1.38, S-RT = 0.69, T = 1.24, T-RT = 0.78, B = 1.79, B-RT = 0.04 . The solution for forecasting the flow of Krian Bypass in 2021. The calculation results made with effective width engineering, turn right and green time can reduce the DS value (Degree of Saturation) still shows DS value> 0.75 - 1, then fly over is constructed with a scenario of 20% vehicles through existing and 80% of vehicles through fly over. Year 2021 The impact of fly over shows North DS = 0.4, South = 0.51, East = 0.56, and West = 0.45
Analisis Kinerja Dan Manajemen Lalu Lintas pada Bundaran ITS dan Bundaran Mulyosari Kota Surabaya
Authors: Satoinong Laif , Mardijono Mardijono , Donny Shofwan , Ray Norman , Budi Leonardus Setia
Published: April 2019

The aim of this thesis is solving the problem of jamming it happen at ITS roundabout and Mulyosari. In research and management of data, and theory which use is MKJI of 1997. The solving of this thesis needed as traffic light data on existing situation. Then, there are survey data at ITC roundabout and Mulyosari roundabout on 2018.  The function of this survey is to know about the real condition performance both of Circles.  Finally, both of circles are not effective (Jamming traffic light). Forward, predictions of performance traffic light in 5 years later until 2022 from 2018, finally more not effective. In this thesis gives the solution in case should use the traffic light. Finally, the solution as counting, that both of roundabout about traffic light become effective.
Optimalisasi Anggaran Biaya Proyek Pembangunan Villa Grand Sinensis Menggunakan Metode Value Engineering
Authors: Koilmo Markus , Yakin Kusnul , Octaviani Maulidya
Published: April 2019

Along with the time, the rise of development in various cities in Indonesia is also increasing. This phenomenon leads to the increase of development demands in all fields, especially in developing cities. One specific place in Malang City that is under the elite settlements construction is the one that located in Tegal Rejo Street 22, Ketindang, Lawang. Based on the previous description, it is very important to implement value engineering in the construction project of Grand Sinensis Villa which is expected to bring alternatives to replace old work items as recommendations for the relevant parties, which provides benefits in the form of cost savings. In the process of budget analysis using the value engineering method, there are 4 stages that will be analyzed, namely: Information Phase, Creative Phase, Analysis Phase and Recommendation Phase. From the results of analysis using Value Engineering method, there are obtained several alternatives that can be proposed, namely: work of concrete items using floordeck with cost savings of: 30,910,797 rupiahs and the installation of water heather using GAS with cost savings of 3.230.000 rupiahs.
DNA Barcoding a Complete Matrix of Stereoisomeric Small Molecules
Authors: Gerry Christopher , Wawer Mathias , Clemons Paul , Schreiber Stuart
Published: April 2019

It is challenging to incorporate stereochemical diversity and topographic complexity into DNA-encoded libraries (DELs) because DEL syntheses cannot fully exploit the capabilities of modern synthetic organic chemistry. Here, we describe the design, construction, and validation of DOS-DEL-1, a library of 107,616 DNA-barcoded chiral 2,3-disubsituted azetidines and pyrrolidines. We used stereospecific C–H arylation chemistry to furnish complex scaffolds primed for DEL synthesis, and we developed an improved on-DNA Suzuki reaction to maximize library quality. We then studied both the structural diversity of the library and the physicochemical properties of individual compounds using Tanimoto multi-fusion similarity analysis, among other techniques. These analyses revealed not only that most DOS-DEL-1 members have “drug-like” properties, but also that the library more closely resembles compound collections derived from diversity synthesis than those from other sources (e.g., commercial vendors). Finally, we performed validation screens against horseradish peroxidase and carbonic anhydrase IX, and we developed a novel, Poisson-based statistical framework to analyze the results. A set of assay positives were successfully translated into potent carbonic anhydrase inhibitors (IC50 = 20.1–68.7 nM), which confirmed the success of the synthesis and screening procedures. These results establish a strategy to synthesize DELs with scaffold-based stereochemical diversity and complexity that does not require the development of novel DNA-compatible chemistry.
Experimental Assessment of the Practical Oxidative Stability of Lithium Thiophosphate Solid Electrolytes
Authors: Dewald Georg , Ohno Saneyuki , Kraft Marvin , Koerver Raimund , Till Paul , Vargas Nella , Janek Juergen , Zeier Wolfgang
Published: April 2019

All-solid-state batteries are often expected to replace conventional lithium-ion batteries in the future. However, the practical electrochemical and cycling stability of the best-conducting solid electrolytes, i.e. lithium thiophosphates, are still critical issues that prevent long-term stable high-energy cells. In this study, we use stepwisecyclic voltammetry to obtain information on the practical oxidative stability limit of Li10GeP2S12, a Li2S‑P2S5glass, as well as the argyrodite Li6PS5Cl solid electrolytes. We employ indium metal and carbon black as the counter and working electrode, respectively, the latter to increase the interfacial contact area to the electrolyte as compared to the commonly used planar steel electrodes. Using a stepwise increase in the reversal potentials, the onset potential at 25 °C of oxidative decomposition at the electrode-electrolyte interface is identified. X‑ray photoelectron spectroscopy is used to investigate the oxidation of sulfur(-II) in the thiophosphate polyanions to sulfur(0) as the dominant redox process in all electrolytes tested. Our results suggest that after the formation of these decomposition products, significant redox behavior is observed. This explains previously reported redox activity of thiophosphate solid electrolytes, which contributes to the overall cell performance in solid-state batteries. The stepwise cyclic voltammetryapproach presented here shows that the practical oxidative stability at 25 °C of thiophosphate solid electrolytes against carbon is kinetically higher than predicted by thermodynamic calculations. The method serves as an efficient guideline for the determination of practical, kinetic stability limits of solid electrolytes.