bluuebunny/crossref_metadata_2025 huggingface dataset:
Taman Hutan Kota Patriot Bina Bangsa sebagai Ruang Publik di Kota Bekasi
Authors: Rizky Avinda Ayu Mutiara , Soedwiwahjono Soedwiwahjono , Suminar Lintang
Published: June 2024

Penurunan kualitas kota dapat disebabkan olehbanyaknya pertumbuhan pembangunan yang tidak menyertakan keseimbangan alam. Taman kota dan hutan kota merupakan bagian dari Ruang Terbuka Hijau (RTH) Kawasan Perkotaan. Keduanya termasuk dalam ruang publik yang dapat menginteregasikan manfaat lingkungan dan sosial sekaligus dalam satu waktu. Dalam mencapai perannya, ketersediaan taman kota tidak cukup berdasarkan kuantitasnya saja tetapi perlu melihat kualitas supaya tercipta kawasan perkotaan yang baik dan seimbang. Taman Hutan Kota Patriot Bina Bangsa hadir sebagai taman kota yang memiliki karakteristik hutan kota yang terletak pada pusat Kota Bekasi.Tujuan dari penelitian ini adalah untuk menilai tingkat kualitas Taman Hutan Kota Patriot Bina Bangsa sebagai ruang publik dilihat dari kebutuhan pengunjung, hak pengunjung, dan kebermaknaan pada ruang. Penelitian ini merupakan penelitian kuantitatif dengan pendekatan deduktif. Teknik pengumpulan data yang dilakukan adalah dengan observasi lapangan secara langsung dan studi literatur. Penelitian ini menggunakan teknik analisis skoring dan analisis deskriptif. Penilaian tingkat kualitas Taman Hutan Kota Patriot Bina Bangsa diturunkan dari komponen pembentuk ruang publik yang baik, yaitu aspek kebutuhan pengunjung, aspek hak pengunjung, aspek bermakna pada ruang, dan aspek keamanan. Berdasarkan analisis terhadap keempat komponen tersebut, aspek hak pengunjung mendapatkan skor tertinggi dengan kualifikasi kualitas baik, diikuti dengan aspek bermakna pada ruang memiliki kualifikasi kualitas baik, aspek kebutuhan pengunjung memiliki kualifikasi kualitas baik, dan aspek keamanan memiliki nilai terendah dengan kualifikasi kualitas buruk. Berdasarkan hasil penilaian tingkat kualitas secara keseluruhan, Taman Hutan Kota Patriot Bina Bangsa termasuk dalam kategori kualitas baik.
Implementasi Media Manipulatif Untuk Pemahaman Siswa Dalam Pembelajaran Matematika
Authors: Cahyono Budi , Karoso Subianto , Sugito  , Baso Rachmie Sari
Published: June 2024

Penelitian ini bertujuan dari penelitian ini adalah untuk mengetahui kondisi obyektif media manipulatif dalam meningkatkan pemahaman siswa sekolah dasar khususnya pada mata pelajaran matematika di sekolah dasar, dengan menggunakan metode penelitian kualitatif deskriptif yaitu deskripsi hasil yang diperoleh dari observasi dan wawancara. Media memegang peranan penting dalam proses pembelajaran di kelas khusus pada mata pelajaran matematika yang membutuhkan pemahaman konsep abstrak ke konkret, sehingga guru dapat menggunakan media untuk membantu menyampaikan materi untuk meningkatkan keterlibatan dan ketertarikan siswa terhadap pelajaran di kelas. Hasil penelitian menunjukkan bahwa rata-rata guru dalam mengajar mata pelajaran matematika yang awalnya hanya menggunakan alat bantu sederhana yaitu buku pelajaran dan papan tulis sebagai alat peraga di kelas, kemudian menggunakan alat peraga manipulatif pada saat mentransfer materi kepada siswa agar siswa memahami konsep matematika dengan cara melihat secara langsung pada objek yang dapat mereka sentuh, sehingga dapat meningkatkan pemahaman siswa, serta aktif dan berminat dalam pembelajaran di kelas. Dengan demikian, dapat disimpulkan bahwa media manipulatif dapat meningkatkan pemahaman siswa khususnya pada mata pelajaran matematika, sehingga diharapkan dengan adanya penelitian ini, guru dapat mengembangkan media pembelajaran di kelas dengan menggunakan media manipulatif yang disesuaikan dengan materi dan tujuan pembelajaran yang ingin dicapai dengan menggunakan alat dan bahan.
Analisis Motivasi Belajar Informatika Elemen Praktik Lintas Bidang Model Pembelajaran Project Based Learning Berbantuan Media Scratch
Authors: Azariyah Devi Lutfiana , Basori  , Susilowati Emi Budi
Published: June 2024

Motivasi belajar memiliki peranan penting dalam memberikan dorongan, semangat dan rasa senang dalam belajar, sehingga mahasiswa yang memiliki motivasi tinggi akan memiliki energi lebih untuk melakukan proses pembelajaran. Penelitian ini bertujuan untuk mengetahui tingkat motivasi belajar mahasiswa pada mata kuliah informatika elemen praktik lintas bidang model pembelajaran project based learning berbantuan aplikasi Scratch untuk merumuskan sebuah kebijakan terkait proses pembelajaran informatika elemen praktik lintas bidang pada pembelajaran selanjutnya. Metode penelitian yang digunakan adalah metode deskriptif kuantitatif. Hasil penelitian ini diperoleh bahwa pembelajaran Informatika Elemen Praktik Lintas Bidang dengan menggunakan model pembelajaran Project Based Learning berbantuan Aplikasi Scratch dapat mendorong motivasi belajar mahasiswa dengan baik. Hal ini dapat dilihat dari rata-rata tingkat motivasi belajar siswa yang berada pada kategori motivasi belajar tinggi yaitu sebesar 61,9%. sehingga guru mata pelajaran informatika elemen Praktik Lintas Bidang dapat kembali menggunakan model pembelajaran Project Based Learning berbantuan aplikasi Scratch.
Impact of Using PhET and NI Multisim Simulation on Understanding Electrical Circuit Concepts
Authors: Halim A. , Alinda Maiza , Mahzum Elmi , Wahyuni Agus , Ngadimin Ngadimin
Published: June 2024

The lack of physics practicum equipment in schools is one of the reasons why practicum activities are rarely carried out, so many students still do not understand the physics concepts being taught. Therefore, one of the aims of this study is to apply two types of virtual practical media (PhET and NI Multisin simulations) and assess their effectiveness. This research uses a quasi-experimental approach with a non-equivalent control group design. In other words, the study utilized two experimental groups and one control group. All students in class 12 of high school from five localities comprised the research population, and a purposive sampling technique randomly selected a sample of three classes. So we got a sample of class 12-1 science for experimental group 1, class 12-2 science for experimental group 2, and class 12-3 science for the control group. After the testing prerequisites were met, the independent sample t-test at a significance level of 0.05 was used for data analysis. According to the data analysis results, there are significant differences in conceptual understanding between students in the control class, PhET class, and NI Multisim class. The research concludes that lecturers or teachers wishing to conduct virtual practicums in physics learning should utilize the NI Multisim simulation due to its ease of use and its more suitable facilities for the topic under study.
PENERAPAN MODEL PROJECT BASED LEARNING DENGAN ROLE PLAY UNTUK MENINGKATKAN KEMAMPUAN BERBICARA BAHASA JEPANG
Authors: Nurlaili Iva
Published: June 2024

Abstract: Japanese is one of the foreign language subjects in high school which has a level of difficulty for students when studying it. In learning, it was still found that students' Japanese speaking skills were still low. Therefore, this research was conducted with the aim of finding out how to improve students' speaking skills by implementing the Project Based Learning model with role play in class XI MIPA 1 SMA Progresf Bumi Shalawat. The subjects of this research were 25 Phase F students of SMA Progresif Bumi Shalawat. This Classroom Action Research was carried out in 2 learning cycles with 2 meetings each. Based on observations in cycle I, the percentage of completeness in students' speaking skills was 56% and the percentage of completeness in cycle II was 100%. This means that students' speaking ability has increased by 44%, noting that even though there was still 1 person who got a score according to the KKM, namely 75. The most visible thing is that when students work on a project to create speaking conversations, students are given the freedom to create conversations so that participants Students can develop speaking skills by playing roles with groups. So it can be concluded that the project based learning model with role play can improve the ability to speak Japanese on the material of Gakkou no Seikatsu in class XI students at SMA Progresif Bumi Shalawat.
SPECIALIZED CARE FOR CARDIOVASCULAR PATIENTS: SELECTED ASPECTS
Authors:   Russian Research Institute of Health, Moscow, Russia, Zubko Aleksandr
Published: June 2024

Significance. Diseases of the circulatory system are a class of diseases of high social importance and a reservoir for reducing mortality and increasing life expectancy, primarily through improving specialized medical care for working-age patients. The purpose of this study is to assess the results of improving specialized medical care for cardiovascular patients under the federal project “Fight against cardiovascular diseases”. Material and Methods. The analysis is based on data from statistical collections of the Federal Research Institute for Health Organization and Informatics of the Ministry of Health of the Russian Federation, and was focused on evaluating target and actual indicators of the federal project “Fight against cardiovascular diseases”. The content analysis of normative legal documents regulating provision of medical care to patients with cardiovascular diseases has been undertaken. Results. Results of the federal project implemented from October 1st, 2018 to December 31st, 2023, are as follows: 374 regional vascular centers and primary vascular departments were re-equipped (retrofitted); more than 310,000 therapeutic X-ray endovascular interventions were performed; 95.5% of patients who underwent through major cardiovascular surgery are provided with free medications; more than 70% of patients with a high risk of acute cardiovascular event are under medical follow-up and received medical care; hospital mortality from myocardial infarction is under 10%, and hospital mortality from acute cerebrovascular accidents is under16.2%. The standardized mortality rate from diseases of the circulatory system in Russia as a whole decreased by 6.0% in 2022 compared to 2018 and equaled to 408.8 per 100,000population. Conclusion. Implementation of the federal project “Fight against cardiovascular diseases” has made it possible to increase effectiveness of specialized medical care delivery in the Russian Federation primarily due to improved material and technical resources of health care facilities. Coverage of cardiovascular patients with quality clinical follow-up is a hard-to-implement component of the overall process of care delivery to such patients, requiring on-going improvements in the implementation approaches. Progress towards this target is the lowest. In order to achieve quality results in reducing morbidity and mortality from cardiovascular diseases, it is important to timely improve the regulatory framework rather than only develop the resource component.
Analitik Psikolojinin Bireyleşme Kavramı ile Tasavvufun Kemâl Kavramına Kıyaslamalı Bir Yaklaşım
Authors: Okur Süheyb
Published: June 2024

Yüzlerce yıllık bir geçmişe dayalı tasavvufî öğretinin bireyi ulaştırmayı hedeflediği “Kemâl” noktası ile analitik psikolojinin kurucusu Carl Gustav Jung tarafından geliştirilen “Bireyleşme” sistemi kıyaslanarak ele alınmıştır. Tasavvuf bireyi kemâle erdirmek amacıyla ortaya koyduğu ilkelerle sistematik bir yapıdır. İslamiyet çatısı altında var olan bu yapı Müslüman bireylerin kendilerine ve hayatlarına anlam yükleyen manevî bir eğitim metodu olarak birçok mistik öğretiyle benzeşmektedir. Bu mistik öğretilerden biri de Jung’un ortaya koyduğu bireyleşmedir. İnsanın psişik bütünlüğünü hedef alan bu yapı tasavvuf gibi kendi içerisinde belli ilkeleri göz önünde bulundurmaktadır. Bireyleşme dini bir olgu olmamakla birlikte ulaştığı noktada Tanrı vardır ve insanın aşkınlığını hedef alan yapısı ona mistik bir öğreti niteliği de kazandırmaktadır. Var olan bütün mistik öğretiler, insanın içinde potansiyel olarak bulunan aşkın olana-hakikate ulaşma ihtiyacının giderilmesi amacına matuftur. Tasavvuf ve bireyleşme, biri dini diğeri psikolojik bir alt yapıya sahip olarak, yöntemleri farklı olsa da ortak hedeflere giden iki ayrı yapıdır.
Hicrî Dördüncü Asırda Semerkant’ta Yaşayan Fakihler ve Fıkıh İlmine Hizmetleri
Authors: Özdemir Ahmet
Published: June 2024

Sâmânîler döneminde bir süre başşehir olan Semerkant, Mâverâünnehir bölgesinin şehirlerindendir. Semerkant İslam ilimleri için kıymetli âlimlerin yetiştiği ve eserlerin yazıldığı bir bölge olarak tarih boyunca önemini korumuştur. Bu çalışmada, hicrî dördüncü asırda Semerkant’ta yetişmiş fakihlerin hayatları, fıkıh eserleri, hocaları, öğrencileri, kendilerinden sonraki asırlara etkileri ve bölgenin fıkıh mirasına katkısı ele alınmaktadır. Hicrî dördüncü asırda Semerkant’ta fıkıh ilmine hizmet eden fakihlerin tespitinde Semerkant şehrinde doğmuş olanların yanında, başka şehirde doğmuş olmakla birlikte hayatının bir döneminde Semerkant’ta bulunmuş fakihlere de yer verilmiştir. Araştırma konusu dördüncü asırla sınırlandırıldığı için doğum tarihi dördüncü yüzyılın sonunda olup hayatının büyük kısmını beşinci yüzyılda yaşayan fakihlere makalede yer verilmemiştir. Semerkant âlimlerinin özellikle hoca-talebe irtibatı ile dönemin İslam dünyasının pek çok bölgesine tesirleri olmuştur. Makalede bu irtibatlar tespit edilmeye çalışılarak dördüncü asırda bölgeler arasındaki karşılıklı etkileşimin de tespit edilmesi hedeflenmiştir. Makalede Semerkant şehrinin yönetim şekli, yaşantı tarzı, ilim ve kültür hayatı hakkında bilgiler verildikten sonra bu asırda yaşadığı tespit edilebilen fakihlerin hayatı ele alınmıştır. Hicrî Dördüncü Asırda Semerkant’ta Fıkıh İlmi başlığı altında ise, Semerkant’ta mevcut olan fıkıh mezhepleri, bölgedeki fakihlerin yaptıkları hizmetler, eserleri ve etkileri ile öne çıkan fakihler ve Semerkant’ın fıkıh ilmi açısından İslam dünyasındaki konumu ele alınmıştır.
Zeydî Hadis Yorumunda Ehl-i Hadise Meyletme Belirtileri: Yahya b. Hüseyin (ö.298/911) ve Ahmed b. Süleyman (ö. 566/1171) Arasında Bir Karşılaştırma
Authors: Yolaçan Semih
Published: June 2024

Kuruluşu Zeyd b. Ali’ye (öl. 122/740) dayandırılan Zeydiyye mezhebi, Yahyâ b. Hüseyin (öl. 298/911) döneminde hadislerin sıhhatini belirlemede Kur’an’a arzı ve eleştirel aklı önceleyen yapısıyla dikkatleri çekmektedir. Buna göre muhaddisler görüşlerine muhalif olan rivayetleri keskin bir dille reddetme üslubunu tercih etmektedir. Peki, bu üslup aynı şekilde devam etmiş midir yoksa Zeydî düşünce içerisinde diğer fraksiyonlara, özellikle de Ehl-i sünnet düşüncesine yaklaşılarak bir söylem değişikliği olmuş mudur? Makalenin amacı bu soruya cevap bulmaktır. Bu sebeple Hicrî 3. Asırda yaşamış Zeydî âlim Yahyâ b. Hüseyin ile Hicrî 6. Asırda yaşamış olan Ahmed b. Süleyman (öl. 566/1171) arasında bir karşılaştırma yapılarak sorunun cevabı ortaya konulmaya çalışılmıştır. Çalışmamızı Yahyâ b. Hüseyin’in Kitabü’l-ahkâm ve el-Müntehab adlı eserleri ile Ahmed b. Süleyman’ın ahkâm hadislerini derlediği Usulü’l-ahkâm adlı eseri çerçevesinde yaptık. Konuyu iki ilim adamının farklı hükümleri ve aynı hükümlere farklı yorumları şeklinde iki ana başlık ve bunları takip eden alt başlıklar şeklinde ele aldık.
Fâtımî-Karmatî Siyasî ve Askerî İlişkileri (297-469/909-1076)
Authors: Erbaş Furkan
Published: June 2024

Şîa’nın aşırı kollarından bir tanesi olan İsmâiliyye’ye mensup Fâtımîler ile Karmatîler aynı mezhebe bağlı olmalarına rağmen tarihte birbirleriyle mücadele içerisinde olmuşlardır. Mezhep içerisinde yaşanan imâmet tartışmaları Fâtımî ve Karmatîler’in aynı çatı altında birleşmesini engellemiş ve birbirlerine karşı hasmane bir tutum sergilemelerine neden olmuştur. İki tarafın siyasî ve askerî olarak karşı karşıya geldikleri hicrî IV. (miladî X.) asrın ikinci yarısına kadar kendisini gizli düşmanlık olarak gösteren tutum, Halife Mu‘izz’in 359 (970) yılında Suriye topraklarını ele geçirmesiyle birlikte açık bir mücadeleye dönüşmüştür. Mısır, Filistin ve Suriye topraklarında karşı karşıya gelen iki taraf arasında kıyasıya bir rekabet söz konusu olmuştur. Mezhebin ana bünyesini temsil eden Fâtımîler sık sık Karmatîler’in itaatini sağlamaya çalışmasına rağmen bunda ciddi anlamda zorlanmışlardır. Bununla birlikte siyasî ve askerî olarak Karmatîler’e karşı hâkimiyet kurdukları anlarda kısmen de olsa itaatlerini sağlayabilmişlerdir. Fâtımî-Karmatî siyasî ve askerî ilişkilerini ele aldığımız bu çalışmanın amacı İsmâiliyye mezhebi içerisindeki bölünmenin sonraki süreçte ikili ilişkilere yaptığı etkiyi ortaya koymak olacaktır.
Pengaruh Kinerja Keuangan dan Corporate Governance terhadap Nilai Perusahaan Sub Sektor Perbankan
Authors: Sholikhah Lutfiatus , Kurniati Rini Rahayu , Trianti Khoiriyah
Published: June 2024

The aim of this study is to examine the impact of financial performance, namely earning per share (EPS) and debt to equity ratio (DER), as well as corporate governance, namely managerial ownership (MO) and institusional ownership (IO), on firm value measured by price to book value (PBV). Employing a quantitative approach, this research analyzes data extracted from the annual reports of 14 selected companies in the Banking sub-sector from 2018 to 2022. By employing purposive sampling technique, a total of 70 research samples were collected and analyzed using IBM SPSS version 27. The method utilized is multiple linear regression analysis. According to the research findings, earning per share (EPS), managerial ownership (MO), and institusional ownership (IO) in partial t-tests significantly influence firm value (PBV). Meanwhile, debt to equity ratio (DER) in partial t-tests does not significantly affect firm value (PBV). The results indicate that both financial performance (EPS and DER) and corporate governance (MO and IO) have significant impacts on firm value (PBV). The company must increase EPS and managerial ownership to attract investors and enhance its value. Additionally, effective management of DER is necessary to maintain financial stability. Good management of institutional ownership can enhance oversight and company performance, ultimately increasing the company’s value in the capital market
Sampling Conformational Ensembles of Highly Dynamic Proteins via Generative Deep Learning
Authors: Chang Chia-en , Ruzmetov Talant , Hung Ta I , Jonnalagedda Saisri Padmaja , Chen Si-han , Fasihianifard Parisa , Guo Zhefeng , Bhanu Bir
Published: June 2024

Proteins are inherently dynamic, and their conformational ensembles are functionally important in biology. Large-scale motions may govern protein structure–function relationship, and numerous transient but stable conformations of intrinsically disordered proteins (IDPs) can play a crucial role in biological function. Investigating conformational ensembles to understand regulations and disease-related aggregations of IDPs is challenging both experimentally and computationally. In this paper first an unsupervised deep learning-based model, termed Internal Coordinate Net (ICoN), is developed that learns the physical principles of conformational changes from molecular dynamics (MD) simulation data. Second, interpolating data points in the learned latent space are selected that rapidly identify novel synthetic conformations with sophisticated and large-scale sidechains and backbone arrangements. Third, with the highly dynamic amyloid-β1-42 (Aβ42) monomer, our deep learning model provided a comprehensive sampling of Aβ42’s conformational landscape. Analysis of these synthetic conformations revealed conformational clusters that can be used to rationalize experimental findings. Additionally, the method can identify novel conformations with important interactions in atomistic details that are not included in the training data. New synthetic conformations showed distinct sidechain rearrangements that are probed by our EPR and amino acid substitution studies. The proposed approach is highly transferable and can be used for any available data for training. The work also demonstrated the ability for deep learning to utilize learned natural atomistic motions in protein conformation sampling.
Structural Pattern of Emotional Schemas with Adolescents' Self-Injury Behavior Based on Mediating Role of Cognitive Emotion Regulation Strategies
Authors: Manesh Soudabeh Ershadi , Nejad Farzaneh Ghorbani , Moosivand Mahboobeh , Zaremohzzabieh Zeinab , Kulemarzi Mohammad Javad Bagian
Published: June 2024

Non-suicidal self-injury is a common mental health threat among adolescents. This study aimed to investigate the structural relationships between emotional schemas and adolescents' self-injury behavior based on the mediating role of cognitive emotion regulation strategies. The study employed a cross-sectional design, with the statistical population consisting of second high school students in Tehran during the school year of 2022–2023. In this study, 316 students were selected through multistage cluster sampling. Data were collected using a non-suicidal self-injury behavior questionnaire, emotional schemas, and cognitive emotion regulation strategies. Structural Equation Modeling (SEM) in AMOS version 26 was utilized to evaluate the proposed model. The findings indicate that the proposed model fits the data. The results of SEM showed that adaptive emotional schemas have a direct and negative effect on adolescents' self-injury. Additionally, adaptive emotional schemas have an indirect positive effect through maladaptive cognitive emotion regulation and a negative indirect effect through adaptive cognitive emotion regulation on adolescents' self-injury. Moving forward, this study provides an account of cumulative knowledge for addressing the issue of non-suicidal self-injury in Iranian adolescents and may inform future prevention and intervention strategies.
Increased chemosensitivity of IDH1-mutated gliomas due to impairment of RPA1-mediated DNA repair
Authors: Li Zhiqiang , Wang Danwen , Yu Donghu , Li Xinyi , Tang Feng , Wang Zefen
Published: June 2024

Isocitrate dehydrogenase 1 (IDH1) mutation, resulting in the expression of mutant IDH1 (mIDH1), is the most common genetic abnormality in low-grade gliomas and is recognized as a biological marker for better patient prognosis and a robust response to temozolomide (TMZ). To investigate the possible mechanisms of chemosensitivity differences between wild-type (WT) IDH1 and IDH1-mutated gliomas, we conducted immunoprecipitation–mass spectrometry (IP-MS) and coimmunoprecipitation (co-IP) in glioma cells expressing wild-type IDH1 and mIDH1 to identify the specific protein that directly interacts with mIDH1, namely, replication protein A1 (RPA1). Increased expression of RPA1 was significantly associated with low TMZ responsiveness and worse prognosis. Subsequently, we demonstrated that overexpression of RPA1, an essential functional factor in DNA damage repair (DDR), increased TMZ resistance in glioma cells, while treatment with an RPA1 inhibitor (HAMNO) sensitized glioma cells to TMZ both in vitro and in vivo. Moreover, TMZ induced a greater degree of general DNA damage in glioma cells coexpressing mIDH1 and RPA1 than in those coexpressing wild-type IDH1 and RPA1, indicating RPA1 dysfunction in IDH1-mutant glioma cells. Further, mIDH1 directly bound to the DNA binding domain (DBD-A) of RPA1 and then suppressed its binding to single-stranded DNA (ssDNA), consequently leading to blockade of the downstream ATR/CHK1 DNA repair signalling pathway, failure of DNA repair and apoptosis. Taken together, our findings reveal a novel molecular mechanism involved in the chemosensitivity of IDH-mutated gliomas and suggest that targeting RPA1-related DNA repair is a promising therapeutic strategy to increase the TMZ response of IDH1-mutant gliomas. Moreover, the combination of TMZ and (1Z)-1-[(2-hydroxyanilino)methylidene] naphthalen-2-one (HAMNO) may be a clinically effective treatment strategy.
Investigation of the quality characteristics of two varieties of aromatic tobacco leaves utilizing metagenomics and non-targeted metabolomics methodologies
Authors: Wei Jinbin , Zhang Jiandong , Song Kai , Zang Zhipeng , Yang Hongjing , Gao Yuzhen , Wang Zhen , Liu Chen
Published: June 2024

Background
During the fermentation process of tobacco leaves, microorganisms play a vital role in producing various aroma components that significantly influence the flavor of tobacco. Different types of microorganisms with specific functions contribute distinct aroma characteristics to tobacco leaves.
Methods
This study investigates the microbial profiles of light-flavored and strong-flavored tobacco leaves, utilizing Yuxi in Yunnan Province as a representative of light-flavored leaves and Yongzhou in Hunan Province for strong-flavored leaves. Using metagenomic technology, we aim to identify the core functional microorganisms present in these representative tobacco leaf types. In addition, non-targeted metabolomics is employed to identify metabolic differences between the two types of tobacco leaves.
Results
The predominant microorganisms in tobacco leaves consist of Pseudomonas, Sphingomonas, Methylobacterium, Pantoea, Methylorubrum, Aureimonas, Acinetobacter, Enterobacter, Stenotrophomonas, and Xanthomonas. Species difference analysis revealed significant divergences at the genus level between Yunnan (YN) and Hunan (HN) samples, implying that these microbial variances may influence the development of distinct flavors. Examination of the tobacco leaf microbiome through KEGG and CAZymes functional annotations exposed carbohydrate and amino acid metabolism as primary features, with glycoside hydrolases (GH), glycosyl transferases (GT), and carbohydrate esterases (CE) as the key enzymes. Correlation analysis between species and functions in the two tobacco leaf samples showed a notable positive relationship among Pseudomonas, Pantoea, Sphingomonas, and Methylobacterium genera in KEGG carbohydrate and amino acid metabolism functions, and CAZymes GH, CE, and AA annotations, suggesting their significant involvement in the chemical breakdown of tobacco leaves and their potential role in enhancing tobacco quality. Non-targeted metabolomic analysis identified 157 volatile and 648 non-volatile metabolites that differ between Yunnan (YN) and Hunan (HN) samples, indicating potential differences in tobacco styles.
Conclusion
This study provides a theoretical basis for guiding tobacco fermentation and has certain enlightening effects on reducing harmful substances during the fermentation process of tobacco leaves. Therefore, further research on tobacco microbiota will focus on these genera.
Study on finite element modeling method of oral soft and hard tissues based on CBCT images and digital scanning technology
Authors: Tang Ruize , Cui Qing , Ren Shuo , Unurjargal Khadbaatar , Li Jingxu
Published: June 2024

Objective
To study an accurate, efficient, and fast method for creating a three-dimensional finite element model using a combination of oral soft and hard tissue images obtained from various field of view CBCT scans and intra-oral 3D scan.
METHODS
An adult female volunteer was selected, and the mandible was scanned using two different field of view CBCT scans, the resulting images were imported into Mimics, Blue Sky Bio, and 3-Matic software using DICOM format, then it was used to create models of the teeth, periodontal ligament, and mandible bone, respectively. The oral soft tissues and dental arch were scanned using an intra-oral digital scanner. The obtained scans were processed using Geomagic and 3-Matic software to create a gingival model. The created model was meshed, and a three-dimensional finite element model consisting of a tetrahedral mesh was generated.
RESULTS
A comprehensive finite element model consisting of the mandible, dental arch, periodontal ligament, and gingiva was established. The model comprised a total of 222,873 nodes, with the following distribution: 892,871, 40,358, 405,043 and 234,224 for the mandible bone, periodontal ligament, teeth and gingiva, respectively.
CONCLUSION
The modeling method based on different field of view CBCT scans and Intra-oral scan can establish a comprehensive finite element model of the mandible bone and gingiva, which is more accurate, faster, and has a wide range of applicability.
Spatiotemporal prediction of landslide deformation based on temporal graph convolutional networks
Authors: Ma Juan , Yao Leihua , Deng Lizheng , Yang Qiang , Chen Yao , Ouyang Chengyu
Published: June 2024

The displacement-time curves of landslides accurately reflect their movement status. Precise prediction of landslide deformation is the key to successful early warning. Machine-learning techniques have been used to predict the deformation of individual landslide monitoring points with desirable results. However, previous studies have not considered the spatial correlation between the monitoring points arranged in the horizontal and vertical profiles. Based on the deep learning model of a temporal graph convolutional network (T-GCN), a feasible solution was provided to accurately predict the overall deformation of landslides. To capture spatial and temporal correlations simultaneously, this study proposed a T-GCN spatiotemporal prediction method that considers the temporal correlation effects of the external factors inducing landslide deformation and generates comprehensive prediction results. The model combines the characteristics of a graph convolutional network (GCN) and gated recurrent unit (GRU). The GCN was used to determine the spatial correlations between landslide monitoring points, whereas the GRU was used to capture dynamic changes in displacement over time. The T-GCN model was then applied to predict the spatiotemporal deformation of the Dawuchang landslide in the Three Gorges Reservoir area. The experimental results demonstrate that the T-GCN model provides a novel solution for spatiotemporal deformation prediction of landslides and can effectively predict the overall displacement of landslides.
Neural Phase Picker Trained on the Japan Meteorological Agency Unified Earthquake Catalog
Authors: Naoi Makoto , Tamaribuchi Koji , Shimojo Kengo , Katoh Shinya , Ohyanagi Shukei
Published: June 2024

In Japan, one of the most seismically active nations, seismic data from various institutions are shared in real-time and made accessible via the web, which facilitates research by numerous scholars. The Japan Meteorological Agency (JMA), in collaboration with the Ministry of Education, Culture, Sports, Science, and Technology (MEXT), processes these data to compile a “unified earthquake catalog.” This catalog is crucial for developing disaster prevention strategies and significantly enhances societal safety. To facilitate the efficient development of high-quality seismic catalogs from this data, we retrained a deep-learning phase picker, known as a neural phase picker, which has gained prominence in recent years. This retraining was based on manual arrival time measurements provided by the JMA. We utilized the PhaseNet architecture for our model and trained it using 6.1 million three-component seismic waveforms collected between 2014 and 2021. When the original PhaseNet model, which was trained with data from California, was applied to routine Japanese data, its performance was suboptimal, especially with ocean-bottom seismometer records. However, retraining the model with the JMA-unified catalogs and corresponding waveforms significantly enhanced its performance in reading arrival times of natural and low-frequency earthquakes. The retrained model reduced its dependency on the types of stations that were monitored when applying the original PhaseNet and displayed improved performance for waveforms even from stations not included in the training dataset. The performance of the model varied with earthquake magnitude, which highlights the reliance on extensive data on small events in the training set. When integrated into the automatic processing used in the routine operation of the JMA, the model identified a larger number of events, especially smaller ones with undetermined magnitudes, compared to the events recorded by the conventional procedure. Furthermore, leveraging approximately ten times more training data than the California study, we developed and trained PhaseNetWC, which is a model with greater expressiveness than the original PhaseNet. This new model surpassed the performance of its predecessor. The publication and dissemination of these models are anticipated to enhance the analysis of routine observational datasets in Japan.
Development of a framework for comprehensive oral health services provision to the Iranian older people
Authors: Azami-Aghdash Saber , Rastkar-Gharamaleki Shima , Pournaghi-Azar Fatemeh , Poorhashemi-Ardakani SM Hossein
Published: June 2024

Background: The older people faces many Oral Health (OH) problems which have wide range of detrimental effects on their life from different aspects. Countries need to have an effective framework to deal with these problems. Therefore, the aim of this study was to develop an effective framework to provide Comprehensive Oral Health Services (COHS) for the Iranian older people.
Methods: First, a scoping review was done. In the second phase of the study, the viewpoints of 11 experts and service providers were collected through semi-structured interviews. Afterward, a panel of experts was held for designing COHS framework. Finally, a modified Delphi method was used to validate the designed framework.
Results: The designed framework including seven main areas 1) the necessity of COHS 2) the process of providing COHS at different levels of service provision 3) the service package in each level of service provision and the composition of human resources required for them; 4) financing; 5) services providing assessment; 6) the role of organizations and communications to improve the OH and 7) Structures, policies and strategies for improving the OH older people.
Conclusion: The designed framework in this study can be used as an effective policy/approach to policymakers so as to provide a roadmap for improving the OH status of the older people.
Competitive Demands during International Sprint-Distance Triathlon Races according to the Circuit Type: Cycling Influence on the Subsequent Running Performance.
Authors: Espejo Raúl , Martínez-Sobrino Jesús , Veiga Santiago
Published: June 2024

Background. Despite the quantitative importance of the cycling segment in Sprint-Distance Triathlon (SDT), very few studies reported the power output of elite triathletes during races. The aim of this study was to analyse the competitive demands of elite triathletes during the cycling segment of SDT races and their influence on the subsequent running segment performance, considering the different types of race circuits.
Methods. Power variables during the cycling segment as well as the running performance metrics during 82 SDT races organised by World Triathlon (68 Continental Cups and Championships, 12 World Cups and 2 World Triathlon Series) were analysed in 10 male and 7 female U23 participants.
Results. The mean power output (MP) values for males, the number of power peaks (Peak 1 for males and Peak 2 for both genders) and the % of race time spent in high power bands increased as circuits presented a greater technical difficulty. Males spent more % of race time in the low (< 2W/kg) and high (> 6W/kg) but less % of time in the medium (2–6 W/kg) relative power bands than females (p < 0.05). Time spent in medium-high power bands showed large correlation with running ranking, both for males on rolling (r = 0.62) and technical (r = 0.55) courses and for females on rolling courses (r = 0.52).
Conclusions. The competitive demands of the cycling segment during SDT races seem to be dependent on the circuit type and should be taken into account to optimise the subsequent running performance.
Valence or semantic: The role of ambivalence on subjective well- being between cultures and within cultures
Authors: Chen Dian , Liu Ying , Guo Yiting , Zhang Yulin
Published: June 2024

This study explores the impact of two types of self-concept ambivalence—valence ambivalence and semantic ambivalence—on individuals’ subjective well-being. It aims to address why individuals in Eastern cultures, despite their tolerance for inconsistencies and contradictions in their self-concept, often report lower levels of subjective well-being. The results show a significant negative correlation between valence ambivalent self-concept and subjective well-being, while semantic ambivalent self-concept is associated with cognitive flexibility and positively predict subjective well-being. Additionally, the study finds that Chinese participants generally score higher on valence ambivalent self-concept than American participants, but no significant differences are observed in semantic ambivalent self-concept. The research emphasizes the importance of understanding and resolving ambivalent self-concepts for enhancing individuals’ subjective well-being and reveals the role of cultural differences in the relationship between ambivalent self-concept and subjective well-being.
Characteristics of the Integration Sites and Structures of the Tn916 and Its Family
Authors: Song Lei , Duan Jingxiu , Liu Tianren , Sun Jiaojiao
Published: June 2024

Tn916, the most typical conjugative transposon carrying the tetM resistance gene, has been identified in a wide range of genomes. This study utilized the sequence identity of the Tn916 internal integrase in Enterococcus faecalis DS16 to recognize Tn916 (with an identity of > 90%) and Tn916 family members (with identity between 60%-90%) in all currently complete genomes and chromosomes, naming them Tn916.1- Tn916.9, respectively. Tn916 and its family members have similar structures: AT-rich inverted repeats (IRs), with boundaries being AT-rich stem-loop structures; the coupling sequences in the middle are often 5 bp AT-rich regions, and their conserved base being the first base A or the last base T; the stem sequence from the host often matches or complement part of the IR (4 or 5bp). Most Tn916 family members have the ABC gene cluster as their resistance marker gene, and Tn916.7 has vancomycin resistance. Tn916 and its family integrate into genomes which have lower GC% more frequently. Our research revealed the flanking structure characteristics of Tn916 and its family, laying a molecular foundation for further determining their deletion and integration mechanisms, and aiding in controlling the spread of such antibiotic resistance in these conjugative transposons.
The treatment efficacy for Patients Undergoing Combined Transanal-Transabdominal Endoscopic Resection of Colorectal Anastomosis Stenosis
Authors: Wan Taixuan , Ye Fujin , Shi Yunxing , Huang Pinzhu , Alenzi Maram , Luo Shuanglin , Liu Zhanzhen , Cai Yonghua , Xie Hao , Zhou Yihang , Kang Liang , Huang Liang
Published: June 2024

Background: Combined transanal- transabdominal resection of anastomotic stenosis has the potential to restore bowel continuity for patients with instead of suffered colorectal anastomosis stenosis. The objective of this study was to assess the treatment efficacy for patientswho underwent combined transanal- transabdominal resection of colorectal anastomosis stenosis.
Methods: We retrospectively included a cohort of consecutive patients who underwent combined transanal-transabdominal endoscopic resection for colorectal anastomosis stenosis. This study encompassed the period from August 2019 to March 2023. We gathered data pertaining to intraoperative details, mortality, postoperative complications, and the rate of stoma closure. Functional outcomes were assessed using the low anterior resection syndrome (LARS) and Wexner incontinence questionnaires.
Results: A total of 54 patients, comprising 46 men and 8 women, met the inclusion criteria. All patients exhibited anastomotic stenosis resulting from anastomotic leakage or preoperative radiotherapy. The median duration of hospitalization was 15 (11-24) days. No instance of mortality was recorded. The morbidity rate was 15%. After a total follow-up period of 48 months, stoma closure was performed in 49 patients after a median delay of 3.8 (2.5-11) months. At the end of follow-up, two patients with failed stoma closure due to poor functional outcomes of anastomosis, while three patients experienced a recurrence of anastomotic stenosis. Among the 49 patients who were available for follow-up, 35 (71.4%) reported either no or minor LARS symptoms. The median Wexner incontinence score was 8 (0-18). Notably, 13 patients achieved a Wexner incontinence score of 0. Erectile function was assessed in 28 male patients, and 18 of them reported normal postoperative erectile function.
Conclusions: Combined transanal- transabdominal endoscopic resection is an effective approach for treating colorectal anastomosis stenosis, demonstrating a high stoma closure rate, low morbidity associated with complications, and favorable long-term functional outcomes.
A new conjugate gradient algorithm for nonconvex minimization
problem and its convergence properties
Authors: AKDAG Dilara , ALTIPARMAK Ebru , KARAHAN Ibrahim , Jolaoso Lateef Olakunle
Published: June 2024

The primary objective of this paper is to develop a novel and efficient
modified conjugate gradient algorithm for addressing nonconvex minimization
problems. The study demonstrates that the proposed method exhibits a
sufficient descent property regardless of the specific line search
techniques employed. Furthermore, the algorithm is globally convergent
towards solving the given problem, employing both Wolfe and Armijo line
search techniques. To reinforce its efficacy, a numerical example is
presented, utilizing image restoration problem.
COVID-19 vaccination coverage of school-aged children in Santiago, Chile, correlates with socioeconomic status: Longitudinal observational study
Authors: Guerrero-Araya Enzo , Ravello Cesar , Rosemblatt Mario , Perez-Acle Tomas
Published: June 2024

The burden of COVID-19 was heterogeneous, indicating that the effects of this disease are synergistic with both other non-communicable diseases and socioeconomic status (SES), highlighting its syndemic character. While the appearance of vaccines moderated the pandemic effects, their coverage was heterogeneous too, both when comparing different countries, and when comparing different populations within countries. Of note, once again SES appears to be a correlated factor.
We analyzed publicly available data detailing the percentage of school-aged, vaccinated children in different municipalities belonging to the Metropolitan Area (MA) of Santiago, Chile. Vaccination data was compiled per school type, either public, state-subsidized, or private, at three different dates during the COVID-19 pandemic to cover the dispersion of Delta, Omicron, and its subvariants BA.4 and BA.5. We computed the median vaccination ratio for each municipality and school type and calculated their Spearman’s rank correlation coefficient with each one of nine SES indices.
The percentage of school-age children who received vaccinations against COVID-19 correlates with SES. This strong correlation is observed in public and state-subsidized schools, but not in private schools. Although inequity in vaccination coverage decreased over time, it remained higher among students enrolled either in public or state-subsidized schools compared to those of private schools.
Although available data was insufficient to explore plausible causes behind lower vaccination coverage, it is likely that a combination of factors including the lack of proper information about the importance of vaccination, the lack of incentives for children’s vaccination, low trust in the government, and limited access to vaccines for lower-income people, may all have contributed. These findings raise the need to design better strategies to overcome shortcomings in vaccination campaigns to confront future pandemics.
Trial Registration: The present work does not involve clinical trials.
White-Light-Excited Organic Room-Temperature Phosphorescence for Improved In Vivo Bioimaging
Authors: Ding Dan , Li Jisen , Zhang Lutong , Zhang Yifan , Dai Wenbo , Gao Xue , Liu Miao-Chang , wu Hua-yue , Lei Yunxiang , Huang Xiaobo , Zhang Yufan
Published: June 2024

Organic phosphorescence materials offer significant advantages for bioimaging applications. However, most of these materials are excited exclusively by ultraviolet (UV) light, which poses risks to living organisms. Herein, six donor-acceptor type compounds incorporating triazine groups were designed as guests within a doped system. The triazine groups exhibit strong absorption capabilities, enabling the guests to achieve white-light-excited phosphorescence, ultimately resulting in the doped materials displaying a bright afterglow lasting 3-5 s under white-light excitation. The phosphorescence quantum yields of the doped system range from 15% to 75%, with lifetimes between 176 and 401 ms. By leveraging the ability of white-light to penetrate biological tissues, a bioimaging mode which the materials are first concentrated within the organism and then excited was developed, yielding superior imaging effects compared to the traditional method where materials are first excited and then concentrated. Furthermore, these materials were applied in the imaging diagnosis of arteriosclerosis plaques and intestinal diseases, as well as in the navigation for in situ liver tumor surgery, achieving excellent imaging outcomes. This work addresses the limitation of phosphorescent materials relying on UV-light, significantly enhancing their potential for practical applications in clinical imaging.
Towards Precision Medicine: Tailoring Diagnosis Based on MRI Evaluation of Adult Lateral Discoid Meniscus Injury
Authors: Li Minhong , Khan Laiba , Imran Sumera , Fatima Sampana , Wabasa Nasma , Khan Rafia Yasmin , Abrar Muhammad
Published: June 2024

Background
Amongst the various forms of knee joint pathology, lateral discoid meniscus injury presents unique challenge owing to rare incidence and diverse clinical presentations. The advent of MRI has significantly enhanced the ability to visualize and characterize soft tissue injuries, the translation of these imaging findings into meaningful clinical decisions remains a crucial aspect of patient care. The purpose of the study was to evaluate the efficacy of MRI in diagnosis of adult lateral discoid meniscus injury and quantify changes in associated parameters.
Main Body:
Results: The wedge sign was notably reduced in Group A compared to Group B, while the incidence of the fat angle sign exhibited a marked increase compared to Group B. Free edge height, body width, and free edge height/body height of meniscus showed significant elevation compared to Group B, conversely, joint capsule edge height and joint capsule edge height/body height displayed a significant decrease compared to Group B. (P<0.05).
Conclusion
MRI imaging proves to be efficacious in diagnosing lateral discoid meniscus injuries in adults, exhibiting notable differences in related parameters compared to individuals without injury. This underscores its value in injury diagnosis and highlights its potential clinical application.
Multimodal scene-graph matching for cheapfakes detection
Authors: Nguyen Minh-Tam , Nguyen Quynh T. , Dao Minh Son , Nguyen Binh T.
Published: June 2024

The development of technology and social media platforms has led to the proliferation of fake news, including the cheapfakes problem. Cheapfakes can be produced easily and spread quickly; a common type is out-of-context misinformation. It is worth investigating a proper algorithm that can efficiently detect such types of misinformation. In this work, we study a new approach to the detection problem of cheapfakes by using graphical neural networks to detect out-of-context samples using the dataset from the ICME 23 Grand Challenge on Detecting Cheapfakes. Specifically, our model utilizes scene graph matching and a language model pre-trained for the natural language inference task to solve task 1 of the challenge. We also propose effective methods to generate labeled data from an unlabeled training set of the challenge. Our proposed method achieved an F1-score of 85.69% and an accuracy score of 85.50% on the public testing set, surpassing the baseline by 4.69% and 3.60%, respectively.