bluuebunny/crossref_metadata_2025 huggingface dataset:
SGLT-2i para a prevenção de eventos cardiovasculares em portadores com Diabetes mellitus tipo 2
Authors: Barros Wellington Felipe do Nascimento , Oliveira Fábio Henrique Portella Corrêa de
Published: June 2022

Objetivo: Abordar a utilização dos SGLT-2i para a prevenção de eventos cardiovasculares em portadores com diabetes mellitus tipo 2. Materiais e Métodos: Trata-se de um estudo descritivo, do tipo revisão integrativa da literatura. As buscas literárias ocorreram a partir de artigos indexados na SciELO, PubMed e MEDLINE, este último via BVS, no idioma em inglês entre 2017 a 2022 (últimos 5 anos). Para a realização das buscas, foram considerados termos em DeSC e MeSH em associação com operadores booleanos: (Diabetes Mellitus, Type 2) AND (Cardiovascular Diseases) AND (Prevention) AND (Sodium-Glucose Transporter 2 Inhibitors). Resultados: No geral, as análises dos estudos revelaram benefícios em diversos desfechos cardiovasculares. Os SGLT-2i reduziram ECAM, o composto de (morte cardiovascular e HIC), infarto do miocárdio não fatal, HIC ou IC, morte cardiovascular, morte por todas as causas, porém, sem eficácia nos eventos cerebrovasculares. Analisando os resultados cardiovasculares, foram descobertos proteção nos eventos renais, com diminuição na progressão da albuminúria, insuficiência renal e compostos renais. Verificando os subgrupos de pacientes, os SGLT-2i diminuíram vários eventos cardiovasculares principalmente nos indivíduos com IC, DCV, função renal reduzida e DRC, notando-se neste último, melhoras nos eventos renais. Comparações dos SGLT-2i versus outros agentes antidiabéticos realizaram-se, na qual se observaram menores riscos em diferentes eventos cardiovasculares e renais com os SGLT-2i. Conclusão: De fato, a prevenção em diversos desfechos cardiovasculares foi comprovada com os SGLT-2i nos portadores de diabetes mellitus tipo 2.
A relação da variável postural durante o ato miccional com o aparecimento de agravos uroginecológicos: uma revisão integrativa
Authors: Lima Bruna Daniella de Sousa de , Silva Amanda Maria Brito da , Matos Ana Beatriz de Oliveira Vieira , Silva Isadora Lima , Leal Evaldo Sales
Published: June 2022

Objetivou-se analisar a atitude adotada por mulheres durante o ato miccional em situações de higiene precária de sanitários públicos e a relação da variável postural com o aparecimento de agravos uroginecológicos. O presente estudo tratou-se de uma revisão integrativa, realizada com busca em diferentes bases de dados (Sistema Online de Busca e Análise de Literatura Médica (Medical Literature Analysis and Retrieval System Online) (MEDLINE®), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Base de dados em Enfermagem (BDENF) e na Physiotherapy Evidence Database (PEDro), com a utilização dos Descritores em Ciências da Saúde (DeCS): micção, postura, saúde da mulher e avaliação de sintomas. Chegou-se a um total de 01 artigo na MEDLINE, 03 artigos na LILACS, 01 artigo na BDENF e 03 artigos na PEDro. Aponta-se que o comportamento adotado por mulheres durante o ato miccional em sanitários públicos e o aparecimento de agravos uroginecológicos estão interligados e diretamente relacionados a fatores comportamentais ao usar banheiros públicos e a fatores ambientais, acarretando assim, o aparecimento de sintomas do trato urinário inferior. A desmistificação faz-se necessário, e é de suma importância a atuação de uma equipe multiprofissional, ofertando promoção, prevenção, recuperação e a reabilitação à saúde. Compreende-se que, apesar dos importantes achados desse estudo que subsidiarão ações voltadas à agravos uroginecológicos, há algumas limitações, como por exemplo, a escassez de estudos aplicados a temática, o que se leva a necessidade de otimizar a produção acadêmica e científica na área.
O sistema de justiça brasileiro tratado em material paradidático no Ensino Médio Integrado: inquietudes e possibilidades
Authors: Leite Rafael Félix , Melo Beatriz Medeiros de
Published: June 2022

É consenso que a crise do sistema prisional brasileiro representa uma das principais mazelas sociais da história recente do país. Este artigo tem por objetivo apresentar o percurso investigativo na construção de um material paradidático que contribua na qualificação desse debate no Ensino Médio Integrado, dialogando diretamente com o conteúdo programático do componente curricular Sociologia. Essa pesquisa foi desenvolvida no contexto do Programa de Pós-Graduação em Educação Profissional e Tecnológica (ProfEPT/Ifal) a partir da metodologia qualitativa, no tipo Investigación-Acción-Participativa de Fals Borda (1987). Em princípio, realizamos revisão bibliográfica e na etapa diagnóstica aplicamos questionários com o corpo docente de Sociologia de diversos campi do Ifal, realizamos entrevistas semi estruturadas com cinco desses/as profissionais e aplicamos questionários em estudantes do curso de Estradas do campus Maceió. As entrevistas foram processadas à luz da Análise de Conteúdo de Bardin (2011) e foram gerados gráficos para melhor visualização dos dados. A partir desses dados, construímos a versão prévia do Caderno Reflexivo. Esse material foi validado por quatro pesquisadoras/es da temática abordada e por dez professoras/es de Sociologia do Ifal. Avaliamos que esse Caderno pode contribuir para qualificar a discussão sobre o sistema prisional e possibilitar espaços reflexivos em sala de aula que representam um esforço na superação de desigualdades sociais, e que esforços precisam continuar sendo empreendidos neste sentido.
Respostas hemodinâmicas agudas durante exercícios resistidos associados à restrição do fluxo sanguíneo: uma revisão sistemática
Authors: Gomes João Victor Souza , Almeida Maria Tereza de Oliveira , Lima Fernanda Kelly de Melo , Paulo Luana Rocha , Lara Bárbara Marques de Castro , Campos Helton Oliveira
Published: June 2022

O exercício resistido associado à restrição do fluxo sanguíneo tem se mostrado eficaz para hipertrofia e ganho de força muscular. Analisar as respostas hemodinâmicas agudas após exercício resistido associado à restrição do fluxo sanguíneo. MÉTODOS: Para isso, foi realizada uma revisão sistemática de acordo com as diretrizes PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis). As bases de dados utilizadas para a busca na literatura foram PubMed e Web of Science, utilizando os seguintes descritores: blood flow restriction AND hemodynamic responses OR hemodynamic monitoring OR blood pressure OR cardiac output OR heart rate OR vascular resistance. Estudos que analisaram as respostas hemodinâmicas agudas após uma sessão de exercício resistido associado à restrição do fluxo sanguíneo foram incluídos nesta revisão sistemática. Onze estudos que avaliaram variáveis ​​hemodinâmicas foram incluídos. A análise sistemática dos resultados indica que o exercício físico resistido associado à restrição do fluxo sanguíneo resulta em aumento imediato dos níveis pressóricos e da frequência cardíaca. Nos estudos analisados, dez desenhos experimentais avaliaram a pressão arterial sistólica (PAS), diastólica (PAD) e média (PAM). Destes, sete, oito e nove delineamentos experimentais apresentaram aumentos significativos nessas variáveis, respectivamente. Com base na escala PEDro, cinco estudos foram classificados como artigos com baixo risco de viés, enquanto os outros seis foram classificados como médio risco de viés. Com base nos resultados encontrados, conclui-se que o exercício resistido associado à restrição do fluxo sanguíneo tende a promover aumentos significativos nas variáveis ​​hemodinâmicas, como PAS, PAD, PAM e FC.
Estratégias para administração segura de medicamentos utilizadas pelos profissionais de enfermagem no ambiente hospitalar: revisão de escopo
Authors: Silva Maria Amália Lima , Sátiro Luana Silva Pereira , Araújo Amanda Lisboa de , Rodrigues Cláudia Cristiane Filgueira Martins , Alves Kisna Yasmin Andrade , Oliveira Patrícia Medeiros da Silva , Brito Albirea Shinobu Inaoka , Tibúrcio Manuela Pinto , Salvador Pétala Tuani Candido de Oliveira
Published: June 2022

Objetiva-se mapear as estratégias para administração segura de medicamentos utilizadas pelos profissionais de enfermagem no ambiente hospitalar. Trata-se de scoping review conduzida de acordo com a metodologia do Joanna Briggs Institute (JBI). Um protocolo de scoping review foi construído. Foram analisadas publicações da literatura branca e cinzenta. Utilizou-se o software Rayyan para gerenciamento da coleta e seleção dos estudos. A análise se deu por estatística descritiva simples. A amostra final incluiu 97 estudos. Identificou-se uma predominância de estudos publicados na última década, com destaque para maiores publicações no Brasil e o maior número de autores graduados em Enfermagem. Em relação às estratégias utilizadas para administração segura de medicamentos, foram utilizadas 81 (83,51%) “Estratégia para Avaliar”, 15 (15,46%) “Estratégias para Promover” e uma pesquisa utilizou tanto “Estratégias para Promover e Avaliar” (1,03%) a administração segura de medicamentos. As seguintes estratégias foram utilizadas para promover a administração segura de medicamentos: questionários, discussão sobre o tema, observação direta e indireta, checklist, fotografia local, formulários e entrevistas, registro dos erros de medicação, caracterização dos incidentes registrados, técnica de grupo nominal e estruturação de cenários para simulação de eventos adversos.
Ferramentas digitais para o ensino da produção oral em língua inglesa de estudantes equatorianos: uma revisão sistemática
Authors: Santos Jardel Coutinho dos , Soares Emiliana Souza , Costa Mariana Santana Santos Pereira da
Published: June 2022

Este trabalho apresenta uma revisão sistemática com base nos estudos empreendidos por Intriago et al., (2016), Calero et al., (2018), Santamaria et al., (2018), Sevy-Biloon e Chroman (2019), Yumi-Guacho et al., (2020) e Cabrera-Solano (2020 cujo objetivo foi apresentar evidências empíricas sobre a utilização das ferramentas digitais para o ensino da produção oral em língua inglesa no contexto equatoriano de ensino considerando o recorte temporal de 2016 – 2021. A coleta dos dados foi feita nas plataformas digitais nacionais e internacionais de estudos (Google Acadêmico, SCOPUS, Web of Knowledge, Latindex, ERIC). Inicialmente, durante a fase de seleção de artigos, foram encontrados 23 estudos, entretanto, somente seis foram usados segundo os critérios de inclusão e exclusão. Os resultados encontrados mostraram seis diferentes ferramentas (google apps, soundcloud, video blogging, video chat, whatsApp, e portafolio digital) que foram utilizadas em sala de aula e contribuíram no desenvolvimento da produção oral dos estudantes. As implicações desta pesquisa mostram a lacuna de estudos que focam na competência da produção oral dos estudantes da educação básica, além da falta de pesquisas voltadas para aspectos específicos da produção oral, como a melhora da fluidez ou pronunciação.
A Arte na escola e sua importância no processo de Inclusão de pessoas com deficiências
Authors: Barbosa Alex do Carmo , Gonçalo Camilla Viana de Souza , Ferreira Liliane Musumeci
Published: June 2022

O presente artigo visa investigar sobre as contribuições que a Arte pode promover no processo de implantação de uma escola inclusiva. Aborda as relações existentes entre Arte e Inclusão justamente pelo fato desta temática apresentar grande importância no contexto educacional. A pesquisa em questão busca explanar as contribuições que os conhecimentos relacionados à Arte podem promover no processo de transformação de uma escola excludente em uma escola realmente inclusiva. O estudo está pautado na pesquisa do tipo Revisão Bibliográfica ou Revisão Sistemática da Literatura, elaborada a partir de materiais publicados em revistas científicas e sites institucionais além de livros e artigos a fim de obter dados qualitativos uma vez que estes dados visam abordar os aspectos subjetivos de fenômenos sociais e do comportamento humano.
RANCANG BANGUN SISTEM INFORMASI KAS KECIL PADA PERUSAHAAN JASA
Authors: Utami Lila Dini , Tofan Andika , Ayu Kinanti Denissa , Miharja Kasmanto
Published: June 2022

Teknologi adalah sarana yang memudahkan pengguna dalam bentuk informasi yang tepat dan lebih akurat. Teknologi sering digunakan dalam penggunaan aplikasi yang telah diprogram secara otomatis digunakan dalam bidang informasi. Perusahaan jasa adalah salah satu perusahaan yang bergerak di perusahaan pembiayaan yang saat ini memproses dana kas kecil masih menggunakan catatan tertulis dalam buku dan Microsoft Excel, tingkat pengawasan dana keluar relatif rendah, dan risiko kehilangan data laporan atau kerusakan pelaporan data akibat kecelakaan kecil dalam kegiatan sehari-hari juga sering terjadi secara tidak sengaja. Untuk mengatasinya, sistem kas kecil harus mencakup penerimaan kas kecil, prosedur pengeluaran kas kecil, hingga laporan kas kecil. Dalam hal ini, metode waterfall cocok untuk membuat sistem kas kecil sesuai dengan kebutuhan yang dibutuhkan. Sistem kas kecil yang dibuat diharapkan membuat prosedur untuk mengeluarkan dana kas kecil lebih terstruktur dan memberikan kemudahan dalam proses pengolahan data sehingga proses pembuatan laporan menjadi lebih baik di perusahaan jasa
RANCANG BANGUN SISTEM INFORMASI KEARSIPAN PADA BAGIAN KEARSIPAN DAN DOKUMENTASI MAHKAMAH AGUNG RI
Authors: Suryanto Ade , Putra Rizqy Pratama
Published: June 2022

The Indonesian Supreme Court Archives and Documentation Sub-Section requires an information system that supports and provides satisfactory services for archivists, because the current system is still operated conventionally and has not been computerized. The Supreme Court of the Republic of Indonesia as a judicial institution that applies a modern judicial body, currently records management is still using the manual method, namely by using paper. This can cause several problems including corrupted or lost archive data and spending a lot of time in the process of collecting new records. The best solution is to design a web-based archiving information system using the waterfall method, using several web-based application processing software. Hopefully this is the Supreme Court Archives and Documentation Sub Division of the Republic of Indonesia Supreme Court that is easier to collect data on archives and prevent lost or damaged data. Archive staff also benefit from this system because it will reduce the time to find the required records.
IMPLEMENTASI APLIKASI E-COMMERCE UNTUK PEMBERDAYAAN HOME INDUSTRI
Authors: Hermaliani Eni Heni , Fatimah Lia , Qomariyyah Nurul
Published: June 2022

Perkembangan teknologi yang sangat pesat secara langsung maupun tidak langsung mempengaruhi sistem perdagangan. Home Industri merupakan usaha mandiri yang bergerak dibidang penjualan dalam hal ini memproduksi boneka. Mekanisme sistem penjualan saat ini masih menggunakan sistem konvensional dalam hal pencatatan data barang dan laporan data penjualan, sehingga menyulitkan pemilik dalam memperoleh informasi yang akurat. Penelitian ini bertujuan untuk membuat aplikasi e-commerce sebagai aplikasi penjualan online yang dapat membantu masyarakat untuk mendapatkan informasi aktual seputar hasil evaluasi, pengetahuan dan kegiatan-kegiatan pada home industri. Sedangkan metode penelitian meliputi pengumpulan data berupa observasi dan wawancara. Kemudian  model pengembangan sistem dengan metode pendekatan SDLC (System Deployment Life Cycle). Tujuan adanya aplikasi diharapkan dapat memberikan kemudahan kepada masyarakat untuk melakukan pembelian produk tanpa harus datang ke lokasi dan membantu home industri dalam melakukan proses promosi dan penjualan boneka secara efektif dan efisien.
APLIKASI PENCARIAN TEMPAT REPARASI KOMPUTER BERBASIS ANDROID
Authors: Febriyansyah Andri , Kuswanto Herman
Published: June 2022

Komputer merupakan sebuah teknologi yang memiliki beragam kegunaan, sehingga komputer menjadi salah satu hal penting dalam melakukan berbagai kegiatan yang berkaitan dengan pengolahan data. Bagi sebagian pengguna komputer belum mengetahui tentang troubleshooting komputer, hal ini akan menjadi masalah ketika pada saat komputer mengalami kerusakan. Untuk mencari tempat reparasi komputer terkadang masih sulit, bahkan tidak semua tempat dapat menangani kerusakan komputer secara spesifik, sehingga hal ini dapat membuang waktu dan tenaga. Penerapan Sistem Informasi Geografis (SIG) dalam aplikasi smartphone dapat mempermudah seseorang untuk mencari alamat tujuan, sedangkan untuk mencari titik lokasi terdekat pada peta dapat menggunakan algoritma Haversine Formula. Oleh karena itu dibutuhkan suatu aplikasi yang dapat memberikan informasi tentang keberadaan lokasi tempat reparasi komputer. Selain itu untuk kemudahan pengguna juga ditambahkan fitur pada aplikasi yang dapat menghubungkan antara pengguna dengan penyedia jasa reparasi komputer misalnya dengan memberikan status reparasi.
PENERAPAN MODEL PROTOTIPE APLIKASI PERANGKAT LUNAK PEMESANAN AIR BERSIH PDAM TIRTA PAKUAN KOTA BOGOR
Authors: Sismadi Sismadi
Published: June 2022

Pergantian musim penghujan ke kemarau pada suatu wilayah berbeda-beda, akibat siklus tahuanan ini menyisakan berbagai masalah terutama ketersedian air minum sebagai kebutuhan dasar keberlangsungan hidup manusia. Hal ini berdampak pada tinggi-rendahnya transaksi pembelian air minum tangki pada PDAM tirta pakuan yang terletak dikota bogor. Perusahaan air minum pemerintah ini dalam menerima pesanan transaksi pembelian air masih bersifat konvensional atau manual yang tercatat pada buku kertas biasa. Hal ini menimbulkan permasalahan diantaranya kurang akurat dalam pencatatan data pelanggan yang melakukan pemesanan, tidak standarnya akurasi informasi yang tercatat sebab setiap petugas memiliki model tulisan yang berbeda. Pada akhir bulan kesulitan dalam pembuatan laporan terutama pada musim kemarau, pesanan air minum tangki sangat tinggi. Kondisi ini harus dicarikan jalan pemecahannya. Solusi yang memungkinkan dan berbiaya rendah adalah implementasi kedalam sistem berbasis computer. Dengan sistem ini keakuratan informasi terjamin dan terstandarisasi, tidak tergantung dengan kondisi petugas, kemudahan dalam pembuatan laporan diakhir bulan teratasi. Pelanggan tetap dapat diberikan perlakuan lebih baik sehingga pendapatan instansi meningkat. Tingginya transaksi pemesanan pada musim kemarau dapat diatasi dengan baik sehingga kinerja PDAM tirta pakuan  akan menjadi lebih baik dan profit perusahaan terjaga. Pada penerapan sistem pemesanan air minum tangki ini menggunakan model pengembangan perangkat lunak prototype, yang memiliki beberapa tahapan. Perancangan dapat dengan mudah disesuaikan dengan kebutuhan pelanggan dan sangat adaptif terhadap perubahan permintaan pelanggan sehingga sistem sangat ramah dan mudah dioperasikan. Model ini salah satu yang banyak digunakan pada perancangan sistem untuk skala kecil hingga menengah.
ANLISIS MODEL BISNIS SISTEM E-PROCURERMENT TANDAN BUAH SEGAR (TBS) SAWIT PETANI SWADAYA UNTUK MENDUKUNG PROGRAM PENGEMBANGAN BIODIESEL
Authors: Falgenti Kursehi
Published: June 2022

The biodiesel biofuel conversion program requires more Crude Palm Oil (CPO) to produce environmentally friendly fuels. Fresh Fruit Bunches (FFB) from independent smallholders' oil palm lands are relied on to meet CPO needs. To ensure independent smallholders 'palm fruit is actually used in the biodiesel and green fuel program, it is necessary to carry out a digital transformation in the procurement of independent smallholders' FFB by building an integrated e-procurement system makes it easier for DPDPKS to monitor the procurement of FFB by cooperatives and the production of CPO by PKS as raw material for biodiesel. This study aims to analyze the business processes of independent smallholders' FFB procurement to design an integrated independent smallholder FFB e-procurement system, ensuring that CPO production for biodiesel comes from independent smallholder oil palm lands. E-procurement also integrates the FFB harvest schedule managed by the cooperative and the CPO production schedule created by the Palm Oil Mill (PKS). This e-procurement will facilitate the coordination of FFB procurement between PKS and cooperatives and between cooperatives and independent smallholders. This e-procurement is supported by cloud computing technology, allows realtime services to be accessed anytime and anywhere. All procurement activities are recorded in the cloud servicse so that the amount of FFB supply from independent farmers for biodiesel can be monitored as well as downstream biodiesel shipments can be monitored ensuring subsidies for biodiesel distribution are right on target.
PENILAIAN KINERJA TIM EVALUASI PERIJINAN PEMBUKAAN PROGRAM STUDI DENGAN TEKNIK CLUSTERING K-MEANS
Authors: Akil Ibnu
Published: June 2022

Abstrak: Mengelompokan karyawan atau staff mana yang memiliki kinerja yang baik dengan yang kurang baik bisa jadi hal yang krusial. Evaluasi perijinan program studi memerlukan kinerja tim penilai yang tinggi karenanya perlu dikelompokan mana tim penilai yang kinerjanya baik dan yang kurang baik. Clustering merupakan Teknik data mining yang efektif untuk melakukan pengelompokkan. Clustering termasuk ke dalam unsupervised learning. Salah satu Teknik clustering yang cukup terbukti secara empiris adalah K-Means. Tujuan dari penelitian ini adalah melakukan pengelompokkan tim penilai yang berkinerja tinggi dengan yang biasa saja dengan menggunakan Teknik clustering K-Means, guna meningkatkan atau mempercepat proses evaluasi usulan perijinan Program Studi pada Kementerian Pendidikan dan Kebudayaan.
Foraging by estuarine juveniles of two paralichthyid flounders: experimental analyses of the effects of light level, turbidity, and prey type
Authors: Howson UA , Targett TE , Grecay PA , Gaffney PM
Published: June 2022

Juvenile summer flounder Paralichthys dentatus and southern flounder P. lethostigma inhabit turbid salt marsh estuaries. Predation rates by juveniles (50-90 mm) were examined at 5 daytime light levels (6 × 1011 to 2 × 1014 quanta s-1 cm-2) and in darkness and 4 turbidity levels (clear [≤1], 11, 20, and 40 NTU) at an intermediate light level. Both species fed equally well on benthopelagic mysid shrimp and benthic spionid polychaetes at all daytime light levels tested. However, predation on mysids was significantly reduced in the dark. Consumption of polychaetes was not reduced in the dark by either species, illustrating the effectiveness of non-visual foraging methods on benthic prey. Turbidity levels tested did not affect predation on either prey type by either flounder species. Locomotor behavior was examined at the same turbidity levels. P. lethostigma spent more time swimming in the water column than P. dentatus in lower turbidity (clear-20 NTU), and both species reduced swimming at 40 NTU. It appears that both species primarily use a benthic-oriented ambush foraging strategy under high turbidity conditions. This is a particularly pronounced switch in foraging style for P. lethostigma. Estuarine turbidity is increasing due to the impacts of climate change. When turbidity is elevated enough to eliminate light sufficient for visual feeding on mysids (between darkness and the lowest light level tested), feeding on this motile prey is negatively impacted for both species. Turbidity can thus alter foraging modes and types of prey consumed, affecting nursery habitat quality and the prey base supporting these young fishes.
Does antinerve growth factor affect isolated ileal contractility in rat?
Authors: Koc E , Yavuzer S , Ocakcioglu B
Published: June 2022

This study investigates the effects of antinerve growth factor (anti-NGF) application on isolated ileal contractility in the rat. For this purpose, rats were divided into four groups. The control animals (n=8) received only intraperitoneal injection of an isotonic NaCl solution (i.p). Anti-NGF was daily administered intraperitoneally at the dose of 1 ng/g level in the first experimental group (n=8), and at doses of 10 ng/g (n=7) and 40 ng/g (n=7) in the second and third experimental groups, respectively. Seven days after the injections rats were sacrificed and ileum segments were isolated. Responses to acetylcholine (ACh) were evaluated by using standard Tyrode, double-calcium Tyrode and calcium-free Tyrode solutions. The average peak amplitude of ACh-induced contractions recorded in standard Tyrode solution was significantly decreased in all three experimental groups as compared to the control group (p 0.05). When double-calcium Tyrode solution was used as the perfusion medium, the responses to ACh were also lower in all anti-NGF applied groups as compared to its control group (p 0.05). Our results showed that the application of anti-NGF reduced the contractile responses of the rat isolated ileum apparently by decreasing the calcium influx from the extracellular medium.
DEVELOPMENT OF MATHEMATICS LEARNING INSTRUMENTS OF PROBLEM BASED LEARNING MODEL ON SETS MATERIAL FOR THE 7TH GRADE OF JUNIOR HIGH SCHOOL
Authors: Erika Meilinda , Solfitri Titi , Zulkarnain
Published: June 2022

This research purpose is to produce mathematics learning devices such as syllabus, lesson plans, and student worksheets by using Problem Based Learning on sets material for the seventh grade of junior high school. The development model used in this research is the 3-D model, which consists of defining, designing, and developing. Method development in this research is discussion, questions and answers, and assignment. The learning devices that have been developed were validated by three validators and revised according to suggestions from the validators. The average score of the validation results for the syllabus, lesson plans, and student worksheets are 90.25%, 91.25%, and 91.75% with very valid categories. The results of this validation indicate that the syllabus, lesson plans, and student worksheets are feasible to be tested. The researcher conducted trials one by one on six students to see the students’ responses and readability to student worksheets developed with a Problem Based Learning model. It was found that the student worksheets being developed can help them in studying the set material, is easy to understand, the explanation is clear enough and the students’ worksheets look interesting. The product of this research is device learning that is the syllabus, lesson plans, and student worksheets. Based on the results of data analysis and discussion, the syllabus, lesson plans, and student worksheets by using Problem Based Learning model on sets material for the seventh grade of junior high school has fulfilled valid.
TRAVELLING AND DISCOVERING NEW DESTINATIONS AFTER THE COVID-19’S LOCKDOWN: THE ROLE OF ROUTINES AND HABITS
Authors: Borges Ana Pinto , De Almeida António Lopes , Vieira Elvira , Beluccio Matheus
Published: June 2022

The paper identifies the level of importance determined by the consumer as far as traveling and discovering new destinations are concerned, after the lockdown caused by the health crisis triggered by the coronavirus pandemic. A sample of 445 respondents is used, and an ordered logit econometric model is applied to estimate the importance level of travelling and enjoying a new destination considering the respondents’ sociodemographic characteristics and the level of importance attributed to meeting new people, visiting their families, going back to work, meeting their friends, eating out in a restaurant and attending musical and other cultural events. The main conclusions are related to consumers who believe it is very important to travel for specific reasons, such as meeting new people and friends or visiting their families, eating out in a restaurant or attending musical or other cultural events. Family and friends play an important role, considering that to visit them is seen as a priority. This study provides a relevant assessment regarding the priorities defined by the consumers in the scope of the discovery of new destinations, thus providing inputs to the different stakeholders involved in the definition of strategies for the promotion of tourism destinations.
THE CONNECTION BETWEEN COMPETITIVENESS AND SUSTAINABILITY IN TOURISM DESTINATIONS: EXAMINING THE HARD, SOFT, AND MODERATING EFFECTS OF KNOWLEDGE SHARING
Authors: Chin Chee Hua , Lo May Chiun , Winnie Wong Poh Ming
Published: June 2022

This paper aims to assess the impact of hard and soft measures on the competitiveness of tourism destinations. Additionally, this article examines the impact of tourism destination competitiveness on rural tourism sustainability management. Following that, knowledge sharing is used as a moderator variable to demonstrate its moderating effect on the relationship between tourism destination competitiveness and rural tourism sustainability. A total of 390 respondents, including both domestic and international tourists, who visited the six rural tourism destinations in Sarawak, Malaysia, voluntarily participated in this study. A PLS-SEM approach was used to evaluate the developed model, and WarpPLS software was used to perform the PLS estimate and hypotheses testing. The empirical findings indicated that destination appeal, tourism infrastructure, and service quality all have a significant and positive effect on the competitiveness of tourism destinations. Additionally, it was discovered that tourism destination competitiveness has a positive and significant effect on the sustainable management of rural tourism destinations.
THE IMPACT OF HOTEL RESPONSES TO ONLINE NEGATIVE REVIEWS ON CONSUMERS' PURCHASE INTENTION
Authors: Kumar Jeetesh , Maidullah Sana
Published: June 2022

This research investigates the hotel response strategies of businesses being responsive online to stimulate customers purchase intention in eWOM communications. Specifically, this study explores the online managerial responses in terms of length, speed, and relevance of management response to customer negative reviews and how customer personality moderates the purchase intention of the hotel. A non-probability convenience sampling technique was applied to collect 441 responses from Chinese residents who have made online hotel reservations and selected the hotel only after checking the online reviews and the hotel responses. The findings confirm that hotel response to negative reviews has an essential impact on 'consumers' purchase intention and consumer personality traits. Further, the research includes the practical implications for hotels to set up the reply format and carry out effective service recovery through different expression ways of negative reviews response.
Medida del Bienestar Individual con indicadores socioemocionales. Aplicaciones al caso europeo.
Authors: Lasierra Esteban Jose Manuel
Published: June 2022

Con datos de la Encuesta Europea de Calidad de Vida 2011, se exponen las razones y el método para la elaboración de un indicador de bienestar socioemocional subjetivo de tipo cuantitativo aplicando un Sistema de Ecuaciones Estructurales. Las diferencias entre 25 países europeos apuntan a diversos factores socioeconómicos nacionales. A partir de una selección de 7 países del conjunto inicial, se analizan esos factores determinantes del Indicador mediante regresiones. Como variables explicativas encontramos la satisfacción con el trabajo, el nivel de vida, cuestiones relacionadas con la familia, las relaciones sociales y factores sociopolíticos como la confianza institucional y las políticas de bienestar. Los resultados señalan que ese indicador de bienestar permite establecer comparaciones más aproximadas a la realidad que otras medidas. Se observa que las diferencias nacionales muestran realidades dispares a tener en cuenta en las políticas públicas.
Do turbulent business environments shape asymmetric trade policy responses? Insights into the Covid-19 pandemic and the Great Recession
Authors: Kicsi Rozalia , Burciu Aurel , Grosu Veronica , Bostan Ionel
Published: June 2022

Today's pandemic and the Great Recession are the most turbulent moments of the 21st century. The aim of the paper is to explore the pattern of response through mixes of harmful trade policy interventions during these two systemic crises.The descriptive assessment focuses on two broad categories of measures, i.e. import-related and export-related harmful interventions. Some stylized facts emerged from this analysis and conclude that the two major crises led to different responses from governments, driven by specific reasons and needs. These patterns of response challenge the future of international trading system and the behavior of companies in the global business environment. Therefore, this research provides valuable information not only for the business community, but also for policymakers.
Extraction of Biocompatible Collagen From Blue Shark Skins Through the Conventional Extraction Process Intensification Using Natural Deep Eutectic Solvents
Authors: Batista Miguel P. , Fernández Naiara , Gaspar Frédéric B. , Bronze Maria do Rosário , Duarte Ana Rita C.
Published: June 2022

The disposal of large amounts of skin waste resulting from the blue shark fishing industry presents several industrial and environmental waste management concerns. In addition, these marine subproducts are interesting sources of collagen, a fibrous protein that shows high social and economic interest in a broad range of biomedical, pharmaceutical, and cosmetic applications. However, blue shark wasted skins are a poorly explored matrix for this purpose, and conventional collagen recovery methodologies involve several pre-treatment steps, long extraction times and low temperatures. This work presents a new green and sustainable collagen extraction approach using a natural deep eutectic solvent composed of citric acid:xylitol:water at a 1:1:10 molar ratio, and the chemical characterization of the extracted collagen by discontinuous electrophoresis, thermogravimetric analysis, Fourier transformed infrared spectroscopy and circular dichroism. The extracted material was a pure type I collagen, and the novel approach presented an extraction yield 2.5 times higher than the conventional one, without pre-treatment of raw material and reducing the procedure time from 96 to 1 h. Furthermore, the in vitro cytotoxicity evaluation, performed with a mouse fibroblasts cell line, has proven the biocompatibility of the extracted material. Overall, the obtained results demonstrate a simple, quick, cheap and environmentally sustainable process to obtain marine collagen with promising properties for biomedical and cosmetic applications.
Demoralization Effects of Sustainability: Development of a Theoretical Framework and Exploratory Pilot-Study on Moralization and Demoralization Effects in (M)Eating Behavior
Authors: Fenzl Thomas , Weder Franzisca , Voci Denise , Lemke Stella
Published: June 2022

Sustainability is not only a moral compass for organizations of all kinds and shapes; increasingly it can be identified as social representation influencing social practices and behavior. Conceptually inspired by the idea of preferences, conventions, and moral convictions influencing individual behavior and an innovative concept of moral harmonization strategies, this paper introduces a theoretical framework for the conceptualization of moralization effects in sustainability communication in general and food choices in particular. The framework is linked to empirical data from an exploratory qualitative pilot study, in which we conducted guideline-based interviews with 25 international students to gather information on individual perceptions of food choices and eating behaviors. Interview data were analyzed using inductive category formation to explore what role sustainability plays on an individual level in terms of coming in as a value or norm and how much sustainability as a normative principle influences individual decision-making processes and behavior. Based on the results of the pilot study, we hypothesize that food is less “morally overloaded” than expected and sustainability is not a moral imperative related to specific eating behavior. In line with previous findings, our results confirmed that food choices and changes in meat consumption involve a multi-faceted and complex decision-making process, which among others may be heavily influenced by inherent social norms within a person's social network, including family, friends as well as important other peers. Thus, with this preliminary study, we critically challenge existing literature on the influence of sustainability as moral imperative guiding and influencing individual behavior, at least in the domain of food and eating behavior. To elaborate on our proposed framework, additional empirical research is needed from a cultural, sustainability, language, and communication perspective.
A Randomized Controlled Trial on the Efficacy of Xinnaoning Capsule in the Treatment of CSAP Complicated With Qi Stagnation and Blood Stasis Syndrome
Authors: Li Jing , Zhang Ping , Zhang Ying , Wang Haiyun , Wu Liqi , Zhao Junnan , Liu Yue , Zeng Wenying , Guo Renzhen , Mei Jun , Xu Fengqin
Published: June 2022

Objective

This study was designed to explore the efficacy and safety of Xinnaoning Capsule (XNNC) in the treatment of patients with chronic stable angina pectoris (CSAP) complicated with Qi stagnation and blood stasis syndrome.

Methods

A total of 240 patients with CSAP complicated with Qi stagnation and blood stasis syndrome who met the inclusion criteria were enrolled from 8 medical centers across China. The trial treatment lasted 14 weeks, including a 2-week lead-in period and a 12-week double-blind treatment period. Patients in the experimental group were treated with XNNC, while patients in the control group were treated with placebos. Thereafter, examinations were conducted on the efficacy of angina pectoris before and after treatment and the relief of symptoms, followed by the recording of grading changes in angina severity, changes in the number of angina pectoris, and the amount of taken nitroglycerin. Finally, adverse events were assessed.

Results

Compared with the control group, the total score and the effective rate of angina pectoris were significantly increased in the experimental group, accompanied by the statistically significant improvement in the severity of angina pectoris (all p < 0.05). Furthermore, there was no statistically significant difference in the adverse events and serious adverse events between the experimental group and the control group (p = 1.0000) before and after treatment.

Conclusion

XNNC is a safe and effective medicine for patients with CSAP complicated with Qi stagnation and blood stasis syndrome.
Catheter-Based Therapies Decrease Mortality in Patients With Intermediate and High-Risk Pulmonary Embolism: Evidence From Meta-Analysis of 65,589 Patients
Authors: Pietrasik Arkadiusz , Gąsecka Aleksandra , Szarpak Łukasz , Pruc Michał , Kopiec Tomasz , Darocha Szymon , Banaszkiewicz Marta , Niewada Maciej , Grabowski Marcin , Kurzyna Marcin
Published: June 2022

Background

Catheter-directed therapies (CDT) are an alternative to systemic thrombolysis (ST) in pulmonary embolism (PE) patients, but the mortality benefit of CDT is unclear.

Objective

We conducted a systematic review with meta-analysis to compare the efficacy and safety of CDT and ST in intermediate-high and high-risk PE.

Methods

We included (P) participants, adult PE patients; (I) intervention, CDT; (C) comparison, ST; (O) outcomes, mortality, complications, in-hospital treatment, and length of hospital stay; (S) study design, randomized controlled trials (RCTs), or cohort comparing CDT and ST. The primary endpoint was 30-day mortality. Secondary outcomes included treatment-related complications including bleeding, the use of hospital resources, and length of hospital stay.

Results

Eleven studies including 65,589 patients met the inclusion criteria. Thirty-day mortality was lower in the CDT group, compared to ST group [7.3 vs. 13.6%; odds ratio (OR) = 0.51, 95% confidence interval (CI) 0.38–0.69, p < 0.001]. The rates of myocardial injury, cardiac arrest, and stroke were lower in CDT group, compared to ST group (p < 0.001 for all). The rates of any major bleeding, intracranial hemorrhage, hemoptysis, and red blood cell transfusion were lower in patients treated with CDT, compared to ST (p ≤ 0.01 for all). Extracorporeal life support was used more often in patients treated with CDT, compared to ST (0.5 vs. 0.2%, OR = 2.52, 95% CI 1.88–3.39, p < 0.001). The use of hospital resources and length of hospital stay were comparable in both groups.

Conclusion

CDT might decrease mortality in patients with intermediate-high and high-risk PE and were associated with fewer complications, including major bleeding.
Thermo-Hydro-Mechanical Coupling Model of Unsaturated Soil Based on Modified VG Model and Numerical Analysis
Authors: Chen Peipei , Zhang Huanwei , Yang Guangchang , Guo Zhiguang , Yang Gaosheng
Published: June 2022

A modified VG model considering both pore ratio and temperature effect is constructed. Based on the wet-thermal elasticity theory and mixture theory, coupled thermo-hydro-mechanical (THM) equations for moisture migration, heat transfer, and deformation in unsaturated soil are derived. The numerical implementation of the coupled theory was implemented by secondary development in the finite element platform. The validity of the established theoretical equation was verified by comparing it with the experimental data. Then the THM coupling response characteristics and internal mechanism of axisymmetric soil samples were numerically analyzed. Study shows that the water in unsaturated soil migrates from high-temperature zone to low-temperature zone under temperature load, and the permeability will change during the process of moisture absorption and dehydration. Particular attention should pay to the reasonable determination of the parameters in the modified VG model for the warming and cooling process of different measurement points during the numerical calculation. The higher the heat source temperature, the greater the saturation at the specific measurement point of the soil sample at thermal stability. The lower the heat source temperature, the shorter the time required for the saturation to stabilize at the specific measuring point. The volumetric strain of unsaturated soil results from a combination of wet expansion and thermal expansion, which is dominated by wet expansion near the heat source and mainly by thermal expansion far from the heat source. The change of the total displacement with time is dominated by the z-direction displacement, and its change trend along the radial direction is similar to that in the r-direction. The peak of the total displacement curve keeps moving backward with time.
Facilitating the Use of Data From Multiple Sources for Formative Learning in the Context of Digital Assessments: Informing the Design and Development of Learning Analytic Dashboards
Authors: Kannan Priya , Zapata-Rivera Diego
Published: June 2022

Learning analytic dashboards (LADs) are data visualization systems that use dynamic data in digital learning environments to provide students, teachers, and administrators with a wealth of information about student’s engagement, experiences, and performance on tasks. LADs have become increasingly popular, particularly in formative learning contexts, and help teachers make data-informed decisions about a student’s developing skills on a topic. LADs afford the possibility for teachers to obtain real-time data on student performance, response processes, and progress on academic learning tasks. However, data presented on LADs are often not based on an evaluation of stakeholder needs, and have been found to not be clearly interpretable and actionable for teachers to readily adapt their pedagogical actions based on these insights. We elaborate on how insights from research focused on interpretation and use of Score Reporting systems and research on open learner models (OLMs) can be used to inform a research agenda aimed at exploring the design and evaluation of LADs.
Prolactin: The Third Hormone in Breast Cancer
Authors: Schuler Linda A. , O’Leary Kathleen A.
Published: June 2022

Prolactin coordinates with the ovarian steroids to orchestrate mammary development and lactation, culminating in nourishment and an increasingly appreciated array of other benefits for neonates. Its central activities in mammary epithelial growth and differentiation suggest that it plays a role(s) in breast cancer, but it has been challenging to identify its contributions, essential for incorporation into prevention and treatment approaches. Large prospective epidemiologic studies have linked higher prolactin exposure to increased risk, particularly for ER+ breast cancer in postmenopausal women. However, it has been more difficult to determine its actions and clinical consequences in established tumors. Here we review experimental data implicating multiple mechanisms by which prolactin may increase the risk of breast cancer. We then consider the evidence for role(s) of prolactin and its downstream signaling cascades in disease progression and treatment responses, and discuss how new approaches are beginning to illuminate the biology behind the seemingly conflicting epidemiologic and experimental studies of prolactin actions across diverse breast cancers.
Genome-Wide Identification of N6-Methyladenosine Associated SNPs as Potential Functional Variants for Type 1 Diabetes
Authors: Chen Yang , Shen Min , Ji Chen , Huang Yanqian , Shi Yun , Ji Li , Qin Yao , Gu Yong , Fu Qi , Chen Heng , Xu Kuanfeng , Yang Tao
Published: June 2022

Objectives

N6-methyladenosine (m6A) is essential in the regulation of the immune system, but the role that its single nucleotide polymorphisms (SNPs) play in the pathogenesis of type 1 diabetes (T1D) remains unknown. This study demonstrated the association between genetic variants in m6A regulators and T1D risk based on a case-control study in a Chinese population.

Methods

The tagging SNPs in m6A regulators were genotyped in 1005 autoantibody-positive patients with T1D and 1257 controls using the Illumina Human OmniZhongHua-8 platform. Islet-specific autoantibodies were examined by radioimmunoprecipitation in all the patients. The mixed-meal glucose tolerance test was performed on 355 newly diagnosed patients to evaluate their residual islet function. The functional annotations for the identified SNPs were performed in silico. Using 102 samples from a whole-genome expression microarray, key signaling pathways associated with m6A regulators in T1D were comprehendingly evaluated.

Results

Under the additive model, we observed three tag SNPs in the noncoding region of the PRRC2A (rs2260051, rs3130623) and YTHDC2 (rs1862315) gene are associated with T1D risk. Although no association was found between these SNPs and islet function, patients carrying risk variants had a higher positive rate for ZnT8A, GADA, and IA-2A. Further analyses showed that rs2260051[T] was associated with increased expression of PRRC2A mRNA (P = 7.0E-13), and PRRC2A mRNA was significantly higher in peripheral blood mononuclear cell samples from patients with T1D compared to normal samples (P = 0.022). Enrichment analyses indicated that increased PRRC2A expression engages in the most significant hallmarks of cytokine-cytokine receptor interaction, cell adhesion and chemotaxis, and neurotransmitter regulation pathways. The potential role of increased PRRC2A in disrupting immune homeostasis is through the PI3K/AKT pathway and neuro-immune interactions.

Conclusion

This study found intronic variants in PRRC2A and YTHDC2 associated with T1D risk in a Chinese Han population. PRRC2A rs2260051[T] may be implicated in unbalanced immune homeostasis by affecting the expression of PRRC2A mRNA. These findings enriched our understanding of m6A regulators and their intronic SNPs that underlie the pathogenesis of T1D.