bluuebunny/crossref_metadata_2025 huggingface dataset:
EVALUATION OF BILATERAL FOOT DEFORMITY IN PATIENTS WITH HEMIPLEGIC TYPE CEREBRAL PALSY
Authors: Durmaz Sevda Canbay , OZBAG Davut , Solgun Selma , Canbay Ali
Published: January 2024

Aim: The aim of our study is to determine the potential degree of the
deformity that can occur on the healthy foot, which is often neglected
during treatment, in the case that the patient can walk independently,
by evaluating the feet, the stiff and healthy side of patients with
hemiplegic type CP. Patients and Methods: 13 girls and 15 boys, a total
of 28 patients who were diagnosed with hemiplegic type CP were included
in the study. A foot examination was done with a feiss line to determine
the patient’s foot deformity. The midpoint of the patient’s malleolus
medialis and the midpoint of their first metatarsophalangeal joint were
connected with a straight line. Tuberositas ossis navicularis in the os
naviculare was also marked and detected, and its perpendicular distance
to the straight line was approximately measured in centimeters with a
soft tape measure. These measurements were repeated on both feet.
Results: 13 of the participants in the study were girls and 15 of them
were boys. 12 of the patients had right side hemiplegic type CP, while
16 of them had left side hemiplegic type CP. 17 of the patients could
walk independently, 11 could walk with support or an assisting device or
could only stand but not actively walk. The age average of the patients
was 14.5; 42.9% of them were under the age of 10 and 57.1% of them
were 10 years old and above. Conclusion: It could be concluded that the
existing deformities on the stiff side can worsen over time, and a new
deformity can ensue on the healthy side over time as well. We think that
deformities can advance quicker especially in cases who can walk, due to
the effectiveness of their muscle weaknesses, and that these situations
must definitely be evaluated in the treatment.
The impact of COVID-19 pandemic on access to treatment for children with cancer in India and treating centre practices: Results of the InPOG-ACC-20-04 study
Authors: Sharma Jyotsna , mahajan amita , Bakhshi Sameer , Patil Veerendra , Verma Nishant , Radhakrishnan Venkatraman , Singh Amitabh , Kayal Smita , Seth Rachna , Pushpam Deepam , Arora Ramandeep
Published: January 2024

Background The COVID-19 pandemic had led the Indian government to
announce a nationwide lockdown on the 23rd of March 2020. This study
(InPOG-ACC-20-04) aimed to explore the impact of this on the
accessibility of care of children with cancer in India and to see
strategies adopted by hospitals for service delivery during the
lockdown. Procedure Weekly average childhood cancer (<18
years) patient registrations during pre-lockdown period (Jan 1st, 2020
to March 23rd 2020) were compared with the post-lockdown period (Mar
24th, 2020 to May 31st, 2020). The effect on the scheduled treatment was
investigated for the post-lockdown period. A survey of health care
providers was conducted to determine centres’ strategies to deal with
the effect of COVID-19. Results In 30 centres participating in this
study, 1146 childhood cancer patients were registered from Jan 1st, 2020
to May 31st 2020. The weekly average patient registration was 67.3
pre-lockdown and 35.5 post-lockdown which was a decline of 47.3% with
travel distance being a factor. While most centres experience this
decline, there were a few who saw an increase in patient registrations.
Of those patients scheduled for treatment during the post-lockdown
period, 36.1% experience delays in one or more modalities. Centres
adopted several strategies to including modifications to treatment
protocols, increased use of growth factors, and increased support from
social organisations. Conclusion Our multicentre study from India
suggests that the COVID19 pandemic and the lockdown impacted two out of
three children with cancer. The effect of this on survival remains to be
established.
Infiltrative Renal Masses as the First Presentation of Acute Lymphoblastic Leukemia and a Review of the Literature
Authors: Offenbacher Rachel , Heisler Shenel , Ostrodka Leanne , Gennarini Lisa , Tal Adit
Published: January 2024

Acute lymphoblastic leukemia (ALL) accounts for approximately 30 percent
of all childhood cancer. Leukemic infiltration is generally present in
the bone marrow, liver and spleen. It is uncommon to demonstrate
infiltration to the kidneys as an initial presenting feature. We present
the case of an 11-year-old boy who presented with back pain, without
peripheral evidence of bone marrow involvement, who was found to have
bilateral renal masses and 70 percent leukemic blasts upon bone marrow
evaluation.
Management of adrenoleukodystrophy: From pre-clinical studies to the development of new therapies
Authors: Ma Chui Yan , Li Cheng , Zhou Xiaoya , Zhang Zhao , Jiang Hua , Liu Hongsheng , Liao Can , Lian Qizhou
Published: January 2024

X-linked adrenoleukodystrophy (X-ALD) is an inherited neurodegenerative
disorder associated with mutations of the ABCD1 gene that encodes a
peroxisomal transmembrane protein. It results in accumulation of very
long chain fatty acids in tissues and body fluid. Along with other
factors such as epigenetic and environmental involvement, ABCD1
mutation-provoked disorders can present different phenotypes including
cerebral adrenoleukodystrophy (cALD), Adrenomyeloneuropathy (AMN), and
Addison’s disease. cALD is a life-threatening form that causes death in
young children. Bone marrow transplantation and hematopoietic stem cell
gene therapy are only effective when performed at an early stage of
onsets in cALD. Nonetheless, current research and development of novel
therapies are hampered by a lack of in-depth understanding disease
pathophysiology and a lack of reliable cALD models. The ABCD1- and
ABCD1-/ABCD2-/- mouse models and ABCD1- rabbit models created in our
lab, do not develop cALD phenotypes observed in human being. In this
review, we summarize the clinical and biochemical features of X-ALD, the
progress of pre-clinical and clinical studies. Challenges and
perspectives for future X-ALD studies are also discussed.
Study on hemorrhage complications of Coadministration of Dronedarone and Rivaroxaban after Catheter Ablation for Atrial Fibrillation
Authors: Peng Zhang , Mao-Jing WANG , Qing ZHAO , Pin SUN , Shang-Lang CAI , Yan-Qing LIU
Published: January 2024

Objectives To compare the hemorrhage complications between the
coadministration of dronedarone and rivaroxaban and that of amiodarone
and rivaroxaban after radiofrequency ablation in patients with atrial
fibrillation (AF). Methods Fifty patients with AF and abnormal thyroid
function were administered dronedarone and rivaroxaban (Group D-R) after
catheter ablation, and fifty patients with AF and normal thyroid
function received dronedarone and rivaroxaban (Group A-R) after the
operation were matched using propensity score matching. All patients
returned for follow-up once a month for 3 months. The incidence of minor
hemorrhage, massive hemorrhage, thromboembolism, and the recurrence rate
of atrial fibrillation were observed. Results No significant difference
was noted in the incidence of postoperative minor bleeding between the
Group D-R and the Group A-R（2% versus 4%, P=0.558）, and no massive
hemorrhage and ischemic events were detected in both groups. Also, no
significant difference was observed in recurrence rate of AF between two
groups(18% versus 16%, P=0.790). Conclusions Compared to the
coadministration of amiodarone and rivaroxaban, that of dronedarone and
rivaroxaban does not increase the risk of hemorrhage, thromboembolism
and AF recurrence after radiofrequency ablation.
A review of advanced separators for rechargeable batteries
Authors: Luo Wei , Cheng Siling , Zhang Xianghua , Yang Dan , Rui Xianhong
Published: January 2024

The separator is a key component for rechargeable batteries. It
separates the positive and negative electrodes to prevent short-circuit
of the battery and also acts as an electrolyte reservoir facilitating
metal ion transportation during charging and discharging cycles.
Separator selection and use significantly impact the electrochemical
performance and safety of rechargeable batteries. This paper reviews the
basic requirements of rechargeable battery membrane separators and
describes the features, benefits and drawbacks of different types of
membrane separators. The structure, characteristics, fabrication,
modification, and performance of the separators are discussed, including
the microporous membrane, modified microporous membrane, nonwoven
membrane, composite membrane, and electrolyte membrane. Finally, it also
provides the outlook and suggests future directions for this field of
study.
To Treat or Not to Treat? Facing Spontaneous Remission of a Neonatal Malignant Mesenchymal Spindle-Cell Neoplasia
Authors: Venturelli Francesco , Babini Micol , Toni Francesco , Zucchelli Mino , Stella Marcello , Righi Alberto , Melchionda Fraia , Pession Andrea
Published: January 2024

We report a case of malignant mesenchymal spindle-cell neoplasia of the
skull, diagnosed in a female newborn at 13 days of age by biopsy and
subtotal resection. Considering the good clinical condition, the age,
tumor histology and the risks associated with surgery and chemotherapy,
we proposed a “wait and see” approach with a close radiologic
monitoring of the tumor lesion. Surprisingly the tumor showed
spontaneous regression both at MRI and ultrasound evaluations. To date,
after 12 months of observation, MRI showed sustained remission: the
infant recovered from surgery and maintains good clinical condition
while follow-up is ongoing.
Existence and asymptotic behavior of positive solutions for fractional magnetic Kirchhoff type problems with steep potential well
Authors: Huang Ling , wang li , Feng shenghao
Published: January 2024

{We study the existence and asymptotic behavior of positive solutions
for the following fractional magnetic Kirchhoff equation with steep
potential well \begin{align*}
\renewcommand{\arraystretch}{1.25}
\begin{array}{ll} \ds
\left \{
\begin{array}{ll} \ds
\left(a+b\int_{\R^{3}}|(-\Delta)_A^\frac{s}{2}u|^2\,
dx\right)(-\Delta)_A^s
u+V_{\lambda}u=|u|^{p-2}u~~~in~\mathbb{R}^3,
\\ u\in
H^s(\R^3), \\
\end{array} \right .
\end{array} \end{align*} where
$a,~b>0$ are constants, $2
Thalidomide combined with interleukin-2 and interferon α-2b in the treatment of refractory multicentric Castleman disease：Two cases report and literature review
Authors: He Zhendong , Zhou Shengsheng , Yang Haiyan , Huang Fengxiang , Mo Qinli , Bin Yehong , Lan Dong , Ma Jie , Peng Zhigang
Published: January 2024

Castleman’s disease (CD) is a rare lymphoproliferative disease. In
clinical practice, the first-line treatment of multicentric Castleman
disease (MCD) includes glucocorticoid, conventional chemotherapy,
immunomodulators, and anti-IL-6. However, not all patients benefited
from the first-line regimen, a subset of patients does not respond to
front-line therapy and is considered to have primary refractory MCD.
Thus, it is urgent to explore alternative treatments to provide new hope
for the treatment of MCD. We report two cases of refractory MCD who
achieved complete remission by thalidomide combined with interleukin-2
and interferon α-2b. The literature on the treatment of refractory MCD
is reviewed.
Investigation of biochemical changes in barley inoculated with Trichoderma harzianum T-22 under salt stress
Authors: Gupta Sneha , Smith Penelope , Boughton Berin , Rupasinghe Thusitha , Natera Siria , Roessner Ute
Published: January 2024

Increases in soil salinity impact growth and agricultural yield by
inhibiting plant functions. Interactions of fungal endophytes with crop
plants can improve tolerance and is a less expensive approach. Here, the
role of Trichoderma harzianum T-22 in alleviating NaCl-induced stress in
two barley genotypes (cv. Vlamingh and cv. Gairdner) has been
investigated. Metabolomics using GC-MS for polar metabolites and LC-MS
for lipids was employed to provide insights into the biochemical changes
in inoculated roots during the early stages of interaction. T. harzianum
improved root growth of both genotypes in saline conditions whereas
uninoculated roots were significantly shorter after salt treatment. The
fungus reduced relative concentration of sugars in both genotypes under
saline conditions but there was no change in organic acids. Amino acids
decreased only in cv. Gairdner in fungus-inoculated roots under saline
conditions. Lipid analysis suggested that salt stress causes large
changes in roots but that inoculation with fungus greatly reduces the
extent of these changes. By studying a tolerant and a sensitive genotype
and their responses to salt and inoculation we have been able to develop
hypotheses that explain the tolerance of Vlamingh to salt and how fungal
inoculation changes the response of Gairdner to improve its tolerance.
Safe management of acute respiratory failure by mediastinal lymphoma: Transient endotracheal stent placement with short-term extracorporeal membrane oxygenation
Authors: Oyake Momoko , Suenobu Souichi , Hirano Naoki , Goto Hironori , Kuga Shuji , Ihara Kenji
Published: January 2024

Intensive respiratory management under extracorporeal membrane
oxygenation (ECMO) is essential for patients with severe respiratory
failure; however, critical complications during ECMO management are a
matter of concern. We report the case of an adolescent with T-cell
lymphoblastic lymphoma with a respiratory emergency due to compression
of the trachea by an anterior mediastinum tumor, for whom ECMO followed
by endotracheal stent (ES) was urgently introduced. Biopsy and initial
chemotherapy were introduced under short-term management by ECMO for 23
hours. Transient ECMO followed by ES would be a robust option for the
patients at risk of respiratory crisis due to mediastinal tumors.
Hidden Danger of COVID-19 Outbreak: Evaluation of Subclinical Myocardial Dysfunction in Patients with Mild Symptoms
Authors: Gül Murat , İnci Sinan , Aktas Halil , Yildirim Oguz , Alsancak Yakup
Published: January 2024

Background: The COVID 19 infection, which is caused by the novel
coronavirus SARS-CoV-2, has rapidly emerged as a global public health
issue. This study aimed to evaluate whether subclinical myocardial
dysfunction using left ventricular global longitudinal strain (LVGLS) in
non-hospitalized mildly symptomatic COVID-19 patients. Methods: Fifty
(26 male, 24 female) non-hospitalized COVID-19 patients and 50 age- and
sex-matched healthy volunteers have included in the study. Apical four-,
three-, and two-chamber images were analyzed longitudinally by
conventional methods and speckle tracking echocardiography (STE) for
left ventricle functions. Results: The mean age of the COVID-19 patients
was 39.55±8.96, 52% of them were male. The most prevalent presenting
symptoms were fever (in 34 (68%)), asthenia (in 30 (60%)), loss of
appetite (in 21 (42%)), myalgia (in 20 (40%)), and cough (in 13
(26%)). Plasma levels of C-reactive protein (CRP) were significantly
higher in the COVID-19 patients than in the controls (10.84±12.44 vs.
4.50±2.81, p < 0.001). There was no significant difference
between the groups in terms of standard echocardiography and Doppler
parameters (p>0.05). Left ventricular longitudinal strain
and strain velocity parameters were significantly decreased in COVID-19
patients compared to healthy individuals. LV-GLS values (-21,72 ± 3,85%
vs. -23,11 ± 4,16%; P =0,003) were significantly lower in COVID-19
patients when compared with the healthy controls. Conclusion: Mildly
symptomatic COVID-19 patients also have subclinical myocardial
dysfunction similar to hospitalized patients. STE has the potential for
detecting subclinical LV systolic dysfunction and can provide useful
information on the risk stratification in the mildly symptomatic
COVID-19 population.
Sex-specific reference limits of left ventricular ejection fraction and volumes estimated by gated myocardial perfusion imaging for low-likehood patients in China: a comparison between three quantitative software
Authors: Li Jiajun , Chen Xiangyi , Liu Jingzhe , Fang Wei , Wang Dawei , He Zuo-Xiang
Published: January 2024

Our aim was to derive male and female reference limits of
left-ventricular functional parameters for patients with low-likehood
coronary heart disease using three quantitative methods and determined
the effect of gender, age and body weight on cardiac functional
parameters. One hundred and seventy-five consecutive patients who
defined as low-likehood coronary heart disease patients underwent
adenosine or exercise stress 99mTc-MIBI gated myocardial perfusion
single photon emission computed tomography (SPECT) imaging, left
ventricular (LV) ejection fraction (EF)，end-diastolic volume (EDV)，and
end-systolic volume (ESV) were obtained by QGS, ECToolbox and 4D-MSPECT,
respectively. LVEF and LV volumes determined by gated SPECT are
significantly affected by gender and age, with body weight as a
significant predictor for cardiac volumes. The values of EDV and EF
determined by three methods could be different although they correlate
very well; the reference limit of EDV, ESV and EF calculated by three
methods are established.
Statistical Analysis of Atom-Bond Connectivity related Descriptors and their Polynomials of some molecular structures of COVID-19 drugs
Authors: RAJU CHALUVA , SHAIKH Ameer Basha , D Vyshnavi
Published: January 2024

The statistical analysis of the different versions of the Atom-Bond
Connectivity (ABC) Descriptors (indices) are used to infer the drug
molecular structures that are helpful for chemical and medical
scientists to nd out the chemical and biological characteristics of
drugs. In this article, we compute and analyze the linear and non-linear
regression models of the different versions of ABC indices and their
polynomials of some Molecular structures of COVID-19 drugs.
Efficacy of a Wound Dressing Material on Post-Tooth Extraction Pain and Alveolar Osteitis: A Split-Mouth Randomized Controlled Clinical Trial
Authors: Bedeloğlu Elçin , Arısan Volkan
Published: January 2024

Objective: The aim of this clinical trial was to compare the incidence
of pain and alveolar osteitis following the administration of a
wound-dressing material after the extraction of maxillary premolar
teeth. Material and methods: A total of 112 maxillary premolar teeth
(right and left) in 56 patients were extracted simultaneously. Patients
were randomly divided into two groups: a cotton/gauze pack was applied
in the control group and a wound dressing material was applied in the
experimental group. Incidence of pain (+/-) and alveolar osteitis (+/-)
were recorded after three days. Chi-square test and multiple logistic
regression analysis were used for the statistical analysis
(p<0.05). Results: The final analysis included 51 patients and
102 teeth. A pain was reported by 44 patients (86.27%) at 88 sockets
(86.27%) and alveolar osteitis was detected in 8 sockets (7.84%) of 8
patients (15.68%). A positive pain score was significantly associated
with the sockets in the control group (Odds ratio [OR] = 1.828, 95%
CI = 1.212-3.66, p=0.18), smoking (OR = 1.214, 95% CI = 1.101-3.25,
p=0.012) and insufficient oral hygiene (OR = 1.154, 95% CI =
1.011-3.11, p=0.014). All the sockets with alveolar osteitis (n=8) were
in the control group. Conclusion: The wound dressing material used in
this study might alleviate the pain experienced after the extraction of
maxillary premolar teeth.
Tuning Electronic Structure over Gold Nanocatalysts towards Enhanced Gas-phase Oxidation of Alcohols
Authors: Zhou Yuheng , Wang Zhiqiang , Ye Bin , Ye Bin , Deng Hui
Published: January 2024

Electronic structure of catalysts has a great influence on their
performance and understanding these functional mechanism of electrons
quantitatively in the molecular-scale is of importance to design
efficient catalysts. Herein we study the regulation of electronic effect
on gold catalysts by using the atmospheric oxidation of alcohols as
probe reaction. Binding ligands results in a turnover frequency increase
(6197 h-1 at 220 oC) closing to the best gold catalyst (twinning
structure) reported before. Combining results from X-ray absorption
spectroscopy along with a series of in-situ studies, we reveal that
electronic-rich processes could provide additional active sites for the
reactants under solvent free gas-phase conditions. Theoretical
calculations clarify the regularity that gold surface with lower work
function is favorable to the thermal oxidation process. It provides a
pathway for us to rational design highly efficient precious metal
catalysts in the gas-phase reaction.
Investigation of the effects of cation/anion structure in ionic liquids for extractive desulfurization: QSPR approach
Authors: Moheb-Aleaba Zahra , Nikou Mohammad Reza Khosravi
Published: January 2024

In the present research the best structural descriptors for different
cation and anion were investigated using quantitative structure−property
relationship (QSPR) approach to find proper ionic liquid (IL) for
extractive desulfurization. Five different datasets were collected from
the literature
containing{(Cation/[NTf2]−thiophene−n-heptane),(Cation/[NTf2]−thiophene−n-hexane),(Cation/[FAP]−thiophene−n-heptane),(Cation/[TCM]−thiophene−n-heptane),([C2MIM]/Anion−thiophene−hydrocarbon),([C8MIM]/Anion–thiophene−hydrocarbon)}.
By investigating the various kinds of molecular descriptors, it was
found that the increment of Spanning Tree Number (STN) descriptor as
cation structure descriptor, causes a decrease in mole fraction of
thiophene in IL-rich phase due to the increase in steric hindrance.
Also, it was found that an increase in E1p which represents the density
of atoms projected along the length or unfilled space of the anion value
as anion structure descriptor leads to the decrement of mole fraction of
thiophene in the IL-rich phase
Dynamical analysis of a fractional SIRS model on complex heterogeneous networks
Authors: El-Saka Hala , Arafa Anas , Gouda Mohammed
Published: January 2024

In this paper, a fractional SIRS model on heterogeneous complex networks
is introduced. The asymptotic local and global stability of equilibrium
points are studied, numerical simulation is used to support our
theoretical results and show the effect of fractional order q and the
influence of connectivity between individuals which represented as ψ(t).
Histopathological Changes with Acute Pioglitazone Intoxication and the Effects of Intralipid Emulsion Treatment in Rats
Authors: Taşçı Abdullah , Ak Rohat , Taşçı Ecem Deniz Kırkpantur , Öztürk Tuba Cimilli , Turan Cansu Arslan
Published: January 2024

Introduction: The primary aim of this study is to investigate the
histopathologic effects of acute pioglitazone intoxication and the
effects of intralipid emulsion treatment in reversing these possible
unwanted effects in a rat model. Methods: For the study, 32
Spraque-Dawley rats weighing between 250-300 g were randomly divided
into 4 groups. The first group was the control group and 12.4 ml/kg
normal saline was given by intravenously (IV). 12.4 ml/kg intralipid
emulsion was given to the second group by IV route. ½ LD50 pioglitazone
(1000 mg/kg) per oral (PO) followed by 12.4 ml/kg normal saline IV was
given to the third group. ½ LD50 pioglitazone (1000 mg / kg) PO followed
by 12.4 ml / kg intralipid emulsion IV was then given to the fourth
group. After 24 hours, rats were decapitated and tissue samples were
taken for histopathological examination. Results: The histopathological
scores of liver tissue in the third and fourth groups were significantly
higher than the other groups. The histopathological scores of the kidney
tissue were significantly higher in the second, third and fourth groups
compared to the control group. The histopathological scores of the heart
tissue were examined, no statistically significant difference was found
in our model. ILE itself were found toxic to kidney cells. Conclusion:
Although toxic effects can be observed in the liver and kidney tissues
due to pioglitazone usage, intralipid emulsion treatment is insufficient
to reverse these toxic effects. Toxic effects can be seen in the kidney
tissue due to intralipid treatment and studies on different doses and
timing are needed. Keywords: Pioglitazone, intravenous lipid emulsion,
intoxication, animal model
PORTABLE SINGLE-LEAD EKG KARDIA MOBILE DEVICE IS ACCURATE FOR QTc EVALUATION OF HOSPITALIZED PATIENTS WITH SUSPECTED OF SARS-CoV-2 INFECTION (COVID-19)
Authors: MARIN MARIA , García Angel , Muñoz Oscar , Castellanos Julio , Cáceres Edward
Published: January 2024

INTRODUCTION: The COVID-19 infection, along with various drugs
administered for its treatment may prolong ventricular repolarization
and QT interval, increasing the risk of potentially fatal arrhythmias.
Electrocardiogram (ECG) tracing with conventional devices increases
health worker exposure to COVID-19. METHODS: In sequential tests,
corrected QT interval (QTc) of electrocardiographic tracing obtained
with AliveCor® single-lead (DI) Kardia Mobile (KM) was compared to QTc
obtained with a 12-lead ECG. Authors evaluated numeric precision
(proportion of measurements with a difference <10 msec), and
consistency between the two devices in determining QTc prolongation (QTc
≥470 ms in male, or ≥480 ms in female), with kappa statistics. RESULTS:
Records of 128 hospitalized patients with a suspected or confirmed
COVID-19 diagnosis in the Hospital Universitario San Ignacio, Bogotá
D.C. (Colombia) were included. The QTc interval measured with KM was
similar to the interval measured with conventional ECG (442.5 ± 40.5 vs.
442.4 ± 40.2 ms, p: 0.986). Numeric precision was 93%. Concordance
between the two devices for determining QTc prolongation was excellent,
both in females (kappa: 0.901) and males (kappa: 0.896). CONCLUSION:
Single-lead electrocardiographic tracing obtained with the AliveCor®
Kardia Mobile allows accurate QTc interval assessment. Since KM use is
fast and practical, it is ideal for reducing the exposure time of
healthcare workers in the COVID-19 pandemic. The KM is capable of
detecting prolonged QTc during treatment in COVID-19 patients. KEY
WORDS: Kardia Mobile; AliveCor; corrected QT; QT interval; smart phone,
ventricular arrhythmias, COVID-19.
Omics-guided bacterial engineering of Escherichia coli ER2566 for recombinant protein expression
Authors: Zhou Liz , Ma Yue , Wang Kaihang , Chen Tingting , Huang Yang , Liu Liqin , Li Yuqian , Sun Jie , Hu Yisha , Li Tingting , Wang Yingbin , Zheng Qingbing , Zhao Qinjian , Zhang Jun , Gu Ying , Yu Hai , Li Shaowei , Xia Ningshao
Published: January 2024

The production of exogenous recombinant proteins is constrained by the
complexity of the connections between cellular physiology and
recombinant protein synthesis. Here, we developed a rational and highly
efficient approach to improve bacterial engineering, using HPV16-L1 as a
protein candidate. Comparing the transcriptomic profiles of the strain
under leaky expression and low temperature-induced stress, we found that
leaky expression accelerated host energy metabolism and altered ribosome
synthesis assembly, and inducing overexpression of the heterologous
protein under low-temperature conditions led to an upregulation in
polysaccharide transport, and cell motility, and a downregulation in
oxidation-reduction, and anaerobic respiration. Subsequently, we
selected and knocked out 36 hub genes to determine the potential impact
of these genes on protein production. Deletion of bluF, cydA, mngR, and
udp led to a significant decrease in soluble recombinant protein
production. Moreover, knocking out several motility-related DEGs
(ER2666-ΔflgH-ΔflgL, ER2666-ΔflgH-ΔflgL-ΔflgK) simultaneously improved
the protein yield by 1.5-fold at 24°C or 37°C induction. This study
highlights a rational and efficient strategy to increase the yield of
recombinant proteins in model or non-model organisms, and lays a solid
foundation for the engineering of bacterial strains for recombinant
technological advances.
Comparison of the Outcome of Mechanical Versus Biological Prosthetic Replacement of the Tricuspid Valve in the Ebstein's Anomaly
Authors: Liu Peng , Xia Dong-Sheng , Zhang Guo-Bao , Dong Nianguo , Chen Si
Published: January 2024

Background: Presently, it is still lack of evidence whether a mechanical
prosthesis is superior or inferior to a biological prosthesis in
patients with Ebstein’s anomaly. The aim of this study was to compare
the long-term results of mechanical and biological prostheses of
patients with Ebstein’s anomaly at two major cardiac surgical centers in
central China. Methods: From January 1999 to June 2020, 85 patients with
Ebstein’s anomaly (mean age: 42 ± 17 years, male to female ratio = 19:
66) underwent tricuspid valve replacement. 22 patients (26%) underwent
mechanical valve implantation, and 63 (74%) were implanted with a
bioprosthesis. Median follow-up duration was 145 months and mean
follow-up duration was 146 ± 13 months. Operative results, long-term
survival, and tricuspid valve-related events were compared. Results:
Eight patients suffered from cardiac failure and died within 30 days
after the surgery. Mechanical prostheses demonstrated a better survival
outcome compared with biological prostheses before (p = 0.043) and after
(p = 0.039) propensity score matching. Tricuspid valve-related events
occurred in 20 patients. There was no statistical significance between
mechanical and biological tricuspid valves before (p = 0.87) and after
(p = 0.91) propensity score matching. Conclusions: Tricuspid valve
replacement for patients with Ebstein’s anomaly is a high-risk operation
and should be cautious, especially for patients with poor conditions.
Although mechanical prostheses demonstrated a better survival outcome
compared with biological prostheses in our study, the selection of
prostheses should be individualized and consider each patient’s
characteristics and needs.
Vaping Induced lung Injury in a 14-year-old Girl
Authors: Smith Jonathan , Smedley Matthew , Kansra Sonal , Kulkarni Hemant
Published: January 2024

A previously fit 14-year old girl presented with a 3-day history of
cough, chest discomfort, abdominal pain and rigors, following her first
exposure to vaping 48 hours earlier. Her symptoms rapidly progressed and
she required escalating amounts of respiratory support. Within 48-hours
of presentation she was ventilated at high pressure and progressed to
need oscillation and nitric oxide. She improved by day-8 of symptom
onset and was breathing unassisted in air prior to discharge from
intensive care.
Corrected transposition of great arteries with exertional angina: A case report
Authors: Wan Yu , Xie Zixin , Yang Qi , Deng Mingbin
Published: January 2024

The corrected transposition of great arteries without ventricular septal
defect and pulmonary stenosis is rare in the clinic. We reported a case
of ccTGA with tricuspid valve regurgitation that lead his exertional
angina. Various echocardiographic and CTA methods were useful for its
diagnosis. Although the patient didn’t choose the surgical treatment,
further follow-up was still needed during his conservative treatment
procedure.
Mercury-induced changes in plant proteomes
Authors: Ahmad Javed , Ali Arlene A , Iqbal Muhammad , Qureshi M. Irfan
Published: January 2024

Heavy-metal toxicity severely affects agricultural productivity as well
as the human health worldwide. Among heavy metals with noticeable
noxious effects, mercury (Hg) acts as a potential contaminant, having a
crucial impact on natural resources and crop production. Hg-tolerance
mechanisms in plants are not very clear. Over the years, proteomics has
emerged as a significant tool to explore the plant response and
tolerance mechanisms to Hg stress. Proteins are the functional players
of cells as they regulate the physiological processes. Hg-induced
modulation of proteins has been documented in several plant systems.
Identification of key proteins and their roles in Hg tolerance are
crucial to produce Hg resistance crops, thus contributing to global food
security. Proteomic studies give us a comprehensive idea of protein
networks and signalling pathways involved in Hg detoxification. The
present review provides an overview of proteomic research about Hg
tolerance in the model and non-model plants, offers a broad insight of
stress proteins and highlights various proteomic approaches used to
identify stress-responsive proteins.
Left Ventricle Twist/Torsion Evaluation 6 Months after Rheumatic Aortic Valve Replacement using 2D Speckle Tracking Echocardiography
Authors: Lou Yu Mei , Ge Xiao Ying , Lian Jiang Fang , Shen Wen Jun , Lou Ke Nan , Shao Guo Feng , Tai I Hsin , Hsieh Kai-Sheng
Published: January 2024

Objective: This study aimed to assess the rotation and torsion in the
endocardial, epicardial, and global myocardium using two-dimensional
speckle tracking imaging(2D-STI) in patients with rheumatic heart
disease who underwent aortic valve replacement (AVR). Methods: This
study included 42 AVR patients [(23 F/19 M, aged (62.7±11.2) years]
and 25 normal control [(16 F/9 M, aged (63.3±10.5) years]. 2D-STI
was performed in five consecutive heart beats, and data were stored for
offline analysis using Q-Lab. The peak systolic rotation of the
endocardial, epicardial, and global myocardium in the left ventricular
basal and apical walls were measured using 2D-STI. The torsion and
twisting angles of the sub-endocardial, sub-epicardial, and global
myocardium were calculated. Results: Rotation at the left ventricular
basal level of the study group was not significantly reduced compared
with that in the normal control group. However, at the apical level,
rotation was significantly reduced (p=0.03, 0.003, 0.004). The torsion
angle of the study group was significantly reduced compared with that of
the normal control group (p=0.006, 0.003, 0.003). Furthermore, patients
with different left ventricular ejection function after AVR showed
differences in torsion of the endocardial, epicardial, and global
myocardium. Conclusions: The systolic rotation and twist of the
subendocardial, sub-epicardial, and global myocardium in the left
ventricle were reduced, whereas those at the basal level remained
unchanged. After AVR, old patients have an almost complete recovery of
left ventricular rotational motion at the basal level. 2D-STI is a
useful non-invasive tool for evaluation of the left ventricular regional
function.
Competition shapes individual foraging strategies and fitness consequences in a desert rodent ensemble
Authors: Manlick Philip , Maldonado Karin , Newsome Seth
Published: January 2024

Intraspecific diet variation is widespread, but the causes and
consequences of individual foraging strategies are unclear. Interactions
between competition and resources dictate foraging strategies, but
classical paradigms like optimal foraging and niche theory offer
contrasting predictions for individual consumers. Further, both
paradigms assume that individual foraging strategies optimize fitness,
yet this prediction is rarely tested. We used over 3,500 stable isotope
measurements and six years of capture-mark-recapture data to quantify
the relationship between environmental variation, individual foraging,
and consumer fitness in four desert rodent species. Consistent with
niche theory, we found that individuals contracted their dietary niches
and increased specialisation in response to both intraspecific and
interspecific competition, but the effect was mediated by resource
abundance. However, individual specialists obtained no apparent fitness
benefit from dietary niche contractions and exhibited lower survival
than generalists. These results suggest diet-mediated fitness
consequences can regulate population and community dynamics in
stochastic resource environments.
Clinical characteristics between influenza A and B in emergency from 2018/2019
Authors: Cai Xingdong , Che Li , Zhang Miao , Gao Wutong , Yang Ying , Huang Yuanshun , Zhang Minmin , Zhang Yanrong , Liu Shengming
Published: January 2024

Objectives: This study analyzed the clinical characteristics and
hematologic examination indexes to tell the type of influenza among
patients and provide a basis for the early diagnosis and treatment of
influenza patients. Methods: We collected demographic characteristics
and clinical data from 726 influenza patients and analyzed the impact of
different clinical manifestations and hematological tests on the
measured values of influenza types. Results: The common clinical
manifestations of influenza patients were fever (99.2%), pharyngeal
congestion (97.1%) and cough (80.4%), et al. Those with oneset of
illness with were 19-49 years of age (OR= 0.335, 95% CI: 0.196-0.573)
or had nasal congestion (OR= 0.566, 95% CI: 0.349-0.919) and fever for
more than 3 days (OR= 0.368, 95% CI: 0.214-0.632) tend to were
diagnosed asprone to have influenza B. While those patients with
symptoms of cough (OR=2.119, 95% CI: 1.322-3.389), headache (OR=1.834,
95% CI: 1.157-2.908), muscle pain (OR=1.811, 95% CI: 1.139-2.880), and
blood CPR>8mg/L (OR=2.315, 95% CI: 1.501-3.589) were prone
to have influenza A. Conclusion: By combining clinical manifestations
and laboratory findings, it is possible to initially distinguish the
type of influenza, which can provide assistance in the early treatment
and prognosis of influenza.
Error analysis of an explicit symmetric fourth-order exponential wave integrator Fourier pseudo-spectral method for the Klein-Gordon-Schrödinger equation
Authors: Li Jiyong
Published: January 2024

In this paper, we propose a fourth-order exponential wave integrator
Fourier pseudo-spectral method for the
Klein-Gordon-Schr\”{o}dinger (KGS) equation. The
proposed method is time symmetric and explicit so it is easy to apply by
the fast Fourier transform (FFT). By using the standard energy method
and the mathematical induction, we make a rigorously convergence
analysis and establish error estimates without any CFL condition
restrictions on the grid ratio. The convergence rates of the proposed
scheme are proved to be at the fourth-order in time and spectral-order
in space, respectively, in a generic $H^m$-norm. Extensive
numerical results are reported to confirm our error bounds. Because that
our error estimates are given under the general $H^m$-norm, the
conclusion can easily be extended to two- and three-dimensional problems
without the stability (or CFL) condition under sufficient regular
conditions. The proposed fourth-order method could also find
applications to solve other coupled system such as the
Klein-Gordon-Dirac system.
Dynamical behavior of a stochastic predator-prey system incorporating a prey refuge
Authors: Fu Jing , Zhao Kaili , Cao Siyu
Published: January 2024

In this paper, a stochastic predator-prey system incorporating a prey
refuge is proposed and studied. Sufficient criteria for the existence
and uniqueness of an ergodic stationary distribution of positive
solutions to the system are established through Lyapunov analysis
method. Moreover, we also obtain sufficient criteria for extinction of
the predator population.
Solute carrier family 47 member 1 gene polymorphism detection improves the therapeutic effect of diabetes.
Authors: Song Jing , Luan Jiajie
Published: January 2024

Abstract: Purpose: To explore the impact of SLC47A1 ( Solute carrier
family 47 member 1, SLC47A1 ) gene polymorphism on the treatment of
diabetes, we conducted a statistical analysis of the SLC47A1 genetic
testing results and patient data in the second quarter of 2019 in our
hospital. Methods: We investigated 372 cases of SLC47A1 gene test
reports and patient medical records, collected information on gender,
age, diabetes type, complications and the relationship between genotype
and biochemical indicators before and after metformin treatment to
explore the guiding effect of SLC47A1 gene test on metformin. Results:
GG genotype had the highest incidence in men, <30 years or
type 2 diabetes patients; GA genotypes have the highest incidence in
women, >30 years or type 2 diabetes patients; and AA
genotype have the highest incidence in men, <30 years or type
1 diabetes. Besides, the complications that each genotype tended to
occur were also significantly different. At the same time, compared with
the biochemical parameters before the guidance, the biochemical
parameters after the guidance were significantly improved. In addition,
in all genotypes patients, only patients with AA genotype had the best
improvement in biochemical parameters, Among them, the HbA1b parameters
of the GG genotype patients were significantly reduced; the 2h-CP, HbA1b
and HbA1c parameters of the GA genotype patients were significantly
reduced; and also the Glu, 2h -CP, HbA1b and HbA1c parameters of AA
genotype patients were all significantly reduced. Conclusion: The
guidance of SLC47A1 gene polymorphism on metformin medication could
improve diabetes treatment effect, and patients with AA genotype had the
best treatment effect.
THE THEORY OF THE SINGULAR NUMBERS OF RAMANUJAN-ALHENA
Authors: ORELLANA CARLOS , Orellana Geminis
Published: January 2024

From the erroneous conjecture proposed by Ramanujan in the equation
“2n-A = x2”; “The Ramanujan-Alhena Singular Numbers Theorem” is
proposed so that the substraction of every number 2n with A and whose
result is a perfect square, there will always be one or two integer
answers, only for the case of A = 7; the possibility of infinite
singular numbers is presented.
Pregnancy Outcomes and Associated Factors for Uterine Rupture: A population-based retrospective study
Authors: Wan Sheng , Yang Mengnan , Pei Jindan , Zhao Xiaobo , Zhou Chenchen , Wu Yuelin , Sun Qianqian , Wu Guizhu , Hua Xiaolin
Published: January 2024

Objective To assess the incidence of uterine rupture, its association
with previous uterine surgery and vaginal birth after a caesarean
section (VBAC), and the maternal and perinatal implications. Design
Population-based retrospective study. Setting Shanghai, China.
Participants A total of 209,112 deliveries were attended and 41 uterine
rupture cases were included. Methods All pregnant women treated for
ruptured uterus in one center between 2013 and 2020 were included. Their
case folders retrieved from the medical records room were
retrospectively reviewed. Main outcome measure Adverse maternal and
neonatal outcomes. Results The incidence of uterine rupture was 1.96/10
000 births. 16 (39.0%) had maternal and fetal complications. There were
no maternal deaths secondary to uterine rupture, while perinatal
mortality attributable to uterine rupture was 7.32 %. Among all case,
38 (92.68%) were scarred uterus and 3(7.32%) were unscarred uterus.
The most common cause of uterine rupture was previous cesarean section
while cases with a history of laparoscopic myomectomy often had serious
adverse outcome. 24 (59%) of ruptures were anterior lower uterine
segment. Fetal heart rate monitoring changes are the most reliable
presenting clinical symptom in our study. Conclusion Incidence of
uterine rupture in the study area was consistent with developed
countries. Further improvement in obstetric care and strong
collaboration with referring health facilities was needed to ensure
maternal and perinatal safety.
Salivary biomarkers in COVID-19 patients: the rabbit out of the hat!
Authors: Napodano Cecilia , Callà Cinzia Anna , Fiorito Antonella , Marino Mariapaola , Taddei Eleonora , Cesare Tiziana Di , Passali Giulio Cesare , Santo Riccardo Di , Fantoni Massimo , Urbani Andrea , Paludetti Gaetano , Rapaccini Gian Ludovico , Ciasca Gabriele , Basile Umberto
Published: January 2024

Background: The ongoing outbreak of Coronavirus Disease 2019 (COVID-19)
represents a major threat to human health, which impairs the
functionality of several organs. One of the hardest challenges in the
fight against COVID-19 is the development of wide-scale, effective, and
rapid laboratory tests to control disease severity, progression, and
possible sudden worsening. Monitoring patients in real-time is indeed
highly demanded in this pandemic era when physicians need reliable and
quantitative tools to prioritize patients’ access to intensive care
departments. In this regard, salivary biomarkers are extremely
promising, as they allow for a fast and non-invasive specimens’
collection, which can be repeated multiple times. Methods: We compare
salivary levels of immunoglobulin A subclasses (IgA1 and IgA2) and
free-light chains (FLC k and λ) in a cohort of 29 SARS-CoV-2 patients
and 21 healthy subjects. Results: We found that each biomarkers differs
significantly between the two groups, with p-values ranging from 10-8 to
10-4. The performance ranking of these markers, shows that λFLC level
(p=1.4e-8) is the best-suited candidate to discriminate the two groups,
with an accuracy of 0.94 (0.87-1.00 95% CI), a precision of 0.91
(0.81-1.00 95% CI), a sensitivity of 1.00 (0.96-1.00 95% CI) and a
specificity of 0.86 (0.70-1.00 95% CI). Conclusion: These results
suggest λFLC as an ideal indicator of patient conditions. This is more
strengthened in consideration that λFLC half-life (approximately 6
hours) is significantly shorter than the IgA one (21 days): thus λFLC
appears displaying the potential to effectively monitor patients
fluctuation in real-time
A field theory of life
Authors: Sánchez Francisco , Battaner Eduardo
Published: January 2024

Darwinism and its later developments together constitute a
well-established paradigm. Nevertheless, some aspects of the paradigm
continue to be the subject of animated debate. We show here how field
theory, of the kind habitually used in physics, may offer a fresh
complementary interpretation. We posit the existence of a classical
scalar field, the vital field, whose intensity is sensitive to the
inverse of specific entropy, such that its distribution tends to very
high values in the interior of living beings. The field equations give
rise to the existence of vital field waves, with their corresponding
corpuscles, which we call vitons. To test this model, we have applied it
to two specific problems: a) the intriguing existence of such
progressively complex and improbable living beings, and b) the rapid
difusion of the mutation of an individual to become a collective
mutation of the entire species. This model is neither teleological nor
based on the anthropic principle.
Effect of green tea on antioxidant status in adults: A Systematic Review and Meta-analysis of Randomized Clinical Trials
Authors: Rasaei Niloufar , Aabaghi Omid , Setayesh Leila , Gholami Fatemeh , Siveid Neda , Casazza Krista , MIRZAE khadiheh
Published: January 2024

Abstract Aim: Oxidative stress represents a cornerstone of a wide range
of chronic diseases. Studies have identified an inconsistent effect of
green tea on regulating oxidative stress. We aimed to examine the
evidence from randomized clinical trials (RCTs) to assess the effects of
green tea on oxidative stress markers including malondialdehyde (MDA),
and total antioxidant capacity (TAC) in adults. Methods: A systematic
search of English language publications in PubMed, Scopus and Embase was
performed up to September 1, 2020. Data were pooled using the
random-effects method and were expressed as weighted mean difference
(WMD) and 95% confidence intervals (CI). Results: Fourteen RCTs met
inclusion criteria. There was a significant relationship between green
tea and TAC. Our results indicated that green tea had significant
effects on TAC (weighted mean difference [WMD]: 0.18; 95 % CI,
0.07, 0.29, P =0.001) and significant heterogeneity between studies (I2
= 98.6%, p <0.001) which was largely related to sex and BMI.
Subgroup analysis in TAC identified a significant relationship except in
low dose and obese individuals. No relationship between MDA and green
tea was observed overall and in all subgroups. Conclusions: We found
that the intervention with green tea significantly increased the TAC,
while, it had no significant effect on MDA. Key Words: green tea,
oxidative stress, total antioxidant capacity, malondialdehyde.