bluuebunny/crossref_metadata_2025 huggingface dataset:
Human-to-monkey transfer learning identifies the frontal white matter as a key determinant for predicting monkey brain age
Authors: He Sheng , Guan Yi , Cheng Chia Hsin , Moore Tara L. , Luebke Jennifer I. , Killiany Ronald J. , Rosene Douglas L. , Koo Bang-Bon , Ou Yangming
Published: November 2023

The application of artificial intelligence (AI) to summarize a whole-brain magnetic resonance image (MRI) into an effective “brain age” metric can provide a holistic, individualized, and objective view of how the brain interacts with various factors (e.g., genetics and lifestyle) during aging. Brain age predictions using deep learning (DL) have been widely used to quantify the developmental status of human brains, but their wider application to serve biomedical purposes is under criticism for requiring large samples and complicated interpretability. Animal models, i.e., rhesus monkeys, have offered a unique lens to understand the human brain - being a species in which aging patterns are similar, for which environmental and lifestyle factors are more readily controlled. However, applying DL methods in animal models suffers from data insufficiency as the availability of animal brain MRIs is limited compared to many thousands of human MRIs. We showed that transfer learning can mitigate the sample size problem, where transferring the pre-trained AI models from 8,859 human brain MRIs improved monkey brain age estimation accuracy and stability. The highest accuracy and stability occurred when transferring the 3D ResNet [mean absolute error (MAE) = 1.83 years] and the 2D global-local transformer (MAE = 1.92 years) models. Our models identified the frontal white matter as the most important feature for monkey brain age predictions, which is consistent with previous histological findings. This first DL-based, anatomically interpretable, and adaptive brain age estimator could broaden the application of AI techniques to various animal or disease samples and widen opportunities for research in non-human primate brains across the lifespan.
Pediatric neurosurgical-oncology scope and management paradigms in Sub-Saharan Africa: a collaboration among 7 referral hospitals on the subcontinent
Authors: Haizel-Cobbina Joseline , Chotai Silky , Labuschagne Jason , Belete Addisalem , Ashagere Yordanos , Shabani Hamisi K. , Copeland William , Sichizya Kachinga , Ahmad Misbahu Haruna , Nketiah-Boakye Frank , Dewan Michael C.
Published: November 2023

Background

Understanding of the epidemiology and biology of pediatric CNS tumors has advanced dramatically over the last decade; however there remains a discrepancy in the understanding of epidemiologic data and clinical capacity between high- and lower-income countries.

Objective

We collected and analyzed hospital-level burden and capacity-oriented data from pediatric neurosurgical oncology units at 7 referral hospitals in Sub-Saharan Africa (SSA).

Methods

A cross sectional epidemiological survey was conducted using REDCap at the 7 SSA sites, capturing 3-month aggregate data for patients managed over a total of 9 months. Descriptive statistical analyses for the aggregate data were performed.

Results

Across the neurosurgical spectrum, 15% of neurosurgery outpatient and 16% of neurosurgery operative volume was represented by pediatric neuro-oncology across the 7 study sites. Eighty-six percent and 87% of patients who received surgery underwent preoperative CT scan and/or MRI respectively. Among 312 patients evaluated with a CNS tumor, 211 (68%) underwent surgery. Mean surgery wait time was 26.6 ± 36.3 days after initial presentation at the clinic. The most common tumor location was posterior fossa (n=94, 30%), followed by sellar/suprasellar region (n=56, 18%). Histopathologic analysis was performed for 189 patients (89%). The most common pathologic diagnosis was low grade glioma (n=43, 23%), followed by medulloblastoma (n=37, 20%), and craniopharyngioma (n=31, 17%). Among patients for whom adjuvant therapy was indicated, only 26% received chemotherapy and 15% received radiotherapy.

Conclusion

The histopathologic variety of pediatric brain and spinal tumors managed across 7 SSA referral hospitals was similar to published accounts from other parts of the world. About two-thirds of patients received a tumor-directed surgery with significant inter-institutional variability. Less than a third of patients received adjuvant therapy when indicated. Multi-dimensional capacity building efforts in neuro-oncology are necessary to approach parity in the management of children with brain and spinal tumors in SSA.
De-escalated radiotherapy for HER2-overexpressing breast cancer patients with 1-3 positive lymph nodes undergoing anti-HER2 targeted therapy
Authors: Liu Jing , Huang Suning , Bi Zhuofei , Zhang Xiaoxue , He Ziqing , Lan Xiaowen , Tan Yuting , Lin Xiao , Zhou Wenyi , Huang Xiaobo
Published: November 2023

Background

In the era of anti-HER2 targeted therapy, the potential clinical feasibility of considering HER2-overexpressing breast cancer cases presenting with 1-3 positive axillary lymph nodes as low-risk, and thereby contemplating postoperative radiotherapy reduction, remains an important subject for in-depth examination. The aim of this retrospective study was to evaluate the effectiveness of de-escalated radiotherapy in T1-2N1M0 HER2-overexpressing breast cancer patients receiving anti-HER2 targeted therapy. Specifically, omitting regional lymph node irradiation (RNI) after breast-conserving surgery and only performing whole-breast irradiation or omitting postmastectomy radiation therapy.

Methods

A retrospective analysis was conducted on 429 patients with stage T1-2N1M0 primary invasive HER2-overexpressing breast cancer from our center between 2004 and 2018. Patients who received anti-HER2 targeted therapy were divided into an RNI group and a no RNI group to assess the role of RNI. The prognostic role of RNI was investigated via the Kaplan-Meier method and Cox proportional hazards modeling.

Results

The median follow-up time was 46.8 months (range 7.1–225.8 months). In the anti-HER2 targeted therapy group RNI yielded no significant improvements in invasive disease-free survival (IDFS) (p = 0.940), local-regional recurrence-free survival (p = 0.380), distant metastases-free survival (p = 0.698), or overall survival (p = 0.403). Estrogen receptor (ER) status (hazard ratio [HR] 0.105, 95% confidence interval [CI] 0.023–0.749, p = 0.004) and lymph vascular invasion status (LVI) (HR 5.721, 95% CI 1.586–20.633, p = 0.008) were identified as independent prognostic factors for IDFS, and ER-positive and LVI-negative patients exhibited better prognoses.

Conclusion

Omitting RNI may be a safe option in T1-2N1 HER2-overexpressing breast cancer patients receiving standardized anti-HER2 targeted therapy; particularly in ER-positive or LVI-negative subgroups.
Antioxidant and antidiabetic activity and phytoconstituents of lichen extracts with temperate and polar distribution
Authors: Torres-Benítez Alfredo , Ortega-Valencia José Erick , Jara-Pinuer Nicolás , Sanchez Marta , Vargas-Arana Gabriel , Gómez-Serranillos María Pilar , Simirgiotis Mario J.
Published: November 2023

The objective of this research was to characterize the chemical composition of ethanolic extracts of the lichen species Placopsis contortuplicata, Ochrolechia frigida, and Umbilicaria antarctica, their antioxidant activity, and enzymatic inhibition through in vitro and molecular docking analysis. In total phenol content, FRAP, ORAC, and DPPH assays, the extracts showed significant antioxidant activity, and in in vitro assays for the inhibition of pancreatic lipase, α-glucosidase, and α-amylase enzymes, together with in silico studies for the prediction of pharmacokinetic properties, toxicity risks, and intermolecular interactions of compounds, the extracts evidenced inhibitory potential. A total of 13 compounds were identified by UHPLC-ESI-QTOF-MS in P. contortuplicata, 18 compounds in O. frigida, and 12 compounds in U. antarctica. This study contributes to the knowledge of the pool of bioactive compounds present in lichens of temperate and polar distribution and biological characteristics that increase interest in the discovery of natural products that offer alternatives for treatment studies of diseases related to oxidative stress and metabolic syndrome.
Large chemokine binding spectrum of human and mouse atypical chemokine receptor GPR182 (ACKR5)
Authors: Bonnavion Remy , Liu Shangmin , Kawase Haruya , Roquid Kenneth Anthony , Offermanns Stefan
Published: November 2023

Atypical chemokine receptors (ACKRs) play pivotal roles in immune regulation by binding chemokines and regulating their spatial distribution without inducing G-protein activation. Recently, GPR182, provisionally named ACKR5, was identified as a novel ACKR expressed in microvascular and lymphatic endothelial cells, with functions in hematopoietic stem cell homeostasis. Here, we comprehensively investigated the chemokine binding profile of human and mouse GPR182. Competitive binding assays using flow cytometry revealed that besides CXCL10, CXCL12 and CXCL13, also human and mouse CXCL11, CXCL14 and CCL25, as well as human CCL1, CCL11, CCL19, CCL26, XCL1 and mouse CCL22, CCL24, CCL27 and CCL28 bind with an affinity of less than 100 nM to GPR182. In line with the binding affinity observed in vitro, elevated serum levels of CCL22, CCL24, CCL25, and CCL27 were observed in GPR182-deficient mice, underscoring the role of GPR182 in chemokine scavenging. These data show a broader chemokine binding repertoire of GPR182 than previously reported and they will be important for future work exploring the physiological and pathophysiological roles of GPR182, which we propose to be renamed atypical chemokine receptor 5 (ACKR5).
Applied imagination
Authors: Finn Ed , Torrejon Capurro Carolina , Bennett Michael G. , Wylie Ruth
Published: November 2023

Imagination is a fundamental human capacity, and to navigate our current global challenges, we need to define and encourage the practice of imagination, or what we term “applied imagination.” In this study, we convened a series of focus groups or “virtual salons” to address three guiding questions: (1) How might we define imagination? (2) How might we (or should we) measure imagination? And (3) How might we foster imagination? Our efforts to define applied imagination highlight the crucial role imagination plays in human survival and thriving, the role of social forces in fostering or discouraging imagination, the connection between imagination and faith, and the “dark side” or maladaptive aspects of imagination. The discussions on measuring imagination were quite divided, with some salon participants arguing for the potential of indirect modes for measuring imaginative capacity while others argued that measuring imagination was functionally impossible and morally suspect. Finally, our results around fostering imagination suggest the importance of using play and humor, separating imaginative activities from the everyday, and employing constraints to prompt imaginative responses. We end with a discussion of possible directions for future research and a call to create a transdisciplinary field of imagination studies.
Understanding identity construction among deaf adolescents and young adults: implications for the delivery of person and family-centered care in audiological rehabilitation
Authors: Hlayisi Vera-Genevey , Sekoto Lieketseng Victoria
Published: November 2023

Introduction

The provision of holistic person and family-centered care in the audiological rehabilitation of adolescents and young adults (AYA) requires in-depth consideration of identity construction. The purpose of this research study was to describe the lived experience of identity construction among deaf AYA. The thoughts, perceptions, and feelings of AYA on their identity and the processes underlying the construction of identity, with a focus on navigating disability, social relations and roles, community assimilation and self-perception were explored.

Methods

A qualitative interpretive phenomenological approach was adopted. Participants were a purposive sample of 5 AYA, aged 15 to 19 years. Participants had moderate to profound deafness and were enrolled in schools for the deaf where they partook in semi-structured phenomenological conversations, detailing their lived experiences with identity construction.

Results

The superordinate themes of creating a self-concept, belonging, stress and being deaf emerged from participants' narratives. Identity construction occurs concurrently at several levels. At the personal level, AYA create self-conceived ideals of who they are. At relational level, identity is fostered through person-to-person and person-to-group interactions. At societal level, AYA navigate inherent challenges with hearing impairment and their positionality as deaf individuals.

Conclusions

Understanding the nuances of identity construction gives insights for further research and highlights the self-ascribed identity domains and related psychosocial variables that appeal to person and family-centered care, uncovering opportunities and barriers to successful delivery. Findings have implications for the transitional care of deaf AYA that is responsive to their needs.
U.S. Small-Scale Livestock Operation Approach to Biosecurity
Authors: Morris Glen , Ehlers Shawn , Shutske John
Published: November 2023

Agricultural biosecurity is a pressing global issue that must be given continuous attention by researchers, producers, consumers, and government agencies responsible for food security. This article examines the relevant literature specifically related to recommended practices for U.S. small-scale farms and ranches to minimize potential disease susceptibility in animals and humans. Current training and educational resources appear to focus on mechanisms of disease transmission and ecological and/or social factors that support mitigation efforts. Training against biological incursion and knowledge of diseases are typically focused on serving the continuing educational needs of veterinarians, epidemiological groups, and animal health technicians for large-scale facilities. However, there is a gap in the available resources that could be beneficial to keepers of livestock, smaller farmers, and ranchers who lack the financial capability to employ the most proven prevention or mitigation strategies. There have been limited comprehensive reviews in the U.S. of disease control, perception, education, or analysis on current prevention measures among small-scale producers. Findings from a review of the literature were used to formulate disease-prevention training resources and outreach strategies directed at U.S. small-scale farm operators and those likely to be involved in disease outbreak situations (e.g., veterinarians, first responders, and family members). The evaluation of the current types and causes of diseases, along with their respective level of current threat to agriculture, was a fundamental strategy to achieve this goal while reviewing literature focused on U.S. biosecurity and international biosecurity. Developing an evidence-based approach to prevention measures for biosecurity operations will allow for more effective execution and adoption of protocols for small-scale farms.
Current Knowledge on the Transportation by Road of Cattle, including Unweaned Calves
Authors: Buckham-Sporer Kelly , Earley Bernadette , Marti Sonia
Published: November 2023

Transport conditions have the potential to alter the physiological responses of animals to the psychological or physical stress of transport. Transportation may introduce multiple physical and psychological stressors to unweaned calves and adult cattle, including noise, overcrowding, food and water deprivation, extreme temperatures, commingling with unfamiliar animals, handling by unfamiliar humans, and being placed in a novel environment upon arrival. Apart from these factors, the type of road and even driving skill may affect the welfare of animals. One of the concerns regarding cattle transport is that the handling and marketing of animals prior to a journey may lengthen the period of feed withdrawal. Furthermore, feed withdrawal can impact animal welfare through hunger and metabolic stress. Transportation is also associated with a decrease in animal performance as well as an increase in the incidence of bovine respiratory disease. It is well established that the transportation of cattle is a stressor that causes a quantifiable response; however, excessive stress during transport resulting in physiological or pathological changes can be reduced with best management practices. The objective of this review was to analyse the available scientific literature pertaining to the transport by road of cattle, including unweaned calves.
Overview of Reptile Diversity from Bobaomby Complex, Northern Tip of Madagascar
Authors: Randriamialisoa  , Andriantsimanarilafy Raphali R. , Rakotondrina Alain J. V. , Rakotoarisoa Josué A. , Nasaina Ranaivoson T. , Rabearivony Jeanneney , Raselimanana Achille P.
Published: November 2023

Many studies on reptiles have been conducted across Madagascar but some areas are poorly known in terms of the diversity of reptiles such as the Bobaomby Complex in the northern tip of Madagascar. In February and March 2018, we conducted a biodiversity survey within five sites. This biological survey is to collect scientific information for helping new protected creations. Three main methods were used including pitfall trap, visual and acoustic searching along the transect and refuge examination. In total, we recorded 42 species including 5 chameleons, 8 skinks, 11 geckos, 16 snakes and 2 blinds snake species. All recorded species are endemic to Madagascar except Hemidactylus frenatus, Ebenavia inunguis and Phelsuma abbotti. Rare species known only from a few specimens have been recorded in the Bobaomby Complex: Heteroliodon fohy, Pseudoxyrhopus ambreensis, and Madascincus arenicola. Thirteen species are classified as threatened on the IUCN Red List, of which three are Critically Endangered: Paracontias minimus, Madascincus arenicola, and Paroedura lohatsara; three are Endangered: Heteroliodon fohy, Lycodryas inopinae, and Phisalixella variabilis; and seven are Vulnerable: Brookesia ebenaui, Furcifer petteri, Blaesodactylus boivini, Uroplatus ebenaui, Uroplatus henkeli, Liophidium therezieni and Flexiseps ardouini. Our results reveal the importance of the Bobaomby Complex for conserving reptile diversity and highlight the need to protect it.
Preparation of Graphene Oxide Hydrogels and Their Adsorption Applications toward Various Heavy Metal Ions in Aqueous Media
Authors: Liu Miao , Wang Yi , Wu Yingjun , Liu Chunyang , Liu Xin
Published: November 2023

Graphene oxide is a two-dimensional material that has been extensively studied in various fields due to its good mechanical properties, water dispersibility, and a large number of oxygen-containing functionalities on its surface. In this study, graphene oxide powder was prepared using graphite powder to take advantage of its large specific surface area and abundance of oxygen-containing functional groups. The graphene oxide powder was cross-linked with acrylic acid and acrylamide and polymerized to produce graphene oxide hydrogels, which were used to adsorb four metal ions including Cu(II), Pb(II), Zn(II), and Cd(II) from aqueous solutions. The adsorption performance of the graphene oxide hydrogels was investigated at different pHs, temperatures, initial metal ion concentrations, and competition principles, as well as their adsorption and desorption after three repeated adsorption–desorption experiments. It was found that the graphene oxide hydrogels exhibited good adsorption performance for all four metal ions under different conditions. The graphene oxide hydrogels for the adsorption of Cu(II), Pb(II), Zn(II), and Cd(II) ions were best fitted using the Langmuir monolayer adsorption model and the quasi-secondary reaction kinetic model. Good adsorption was achieved for all four metal ions under different competing adsorption principles. After three adsorption–desorption cycles, the adsorption capacity of the graphene oxide hydrogels for all four metal ions remained at 88% and above. These results indicate that graphene oxide hydrogels are a stable, efficient, low-cost, and reusable adsorbent material for the treatment of metal ions in solution.
Mechanical and Optical Characterization of Lithium-Ion Battery Cell Components/Cross-Ply Lamination Effect
Authors: Sypeck David , Zhu Feng , Deng Jie , Bae Chulheung
Published: November 2023

Excessive mechanical loading of lithium-ion batteries can impair performance and safety. Their ability to resist loads depends upon the properties of the materials they are made from and how they are constructed and loaded. Here, prismatic lithium-ion battery cell components were mechanically and optically characterized to examine details of material morphology, construction, and mechanical loading response. Tensile tests were conducted on the cell case enclosure, anodes, cathodes, and separators. Compression tests on stacks of anodes, cathodes, separators, and jellyrolls were made from them. Substantially differing behaviors were observed amongst all components tested. An optical examination of the anodes, cathodes, and separators revealed homogeneities, anisotropies, and defects. Substantial texturing was present parallel to the winding direction. When highly compressed, jellyrolls develop well-defined V-shaped cracks aligned parallel to the texturing. Like many laminates, altering the lay-up construction affects jellyroll mechanical performance. To demonstrate, a cross-ply jellyroll was fabricated by rotating every other complete component set (cathode/separator/anode/separator), reassembling, and compressing. A distinctly different fracture pattern and increased compressive strength were observed.
Spatial Patterns of Frangula alnus (Rosales: Rhamnaceae): Implications for Invasive Plant Management
Authors: Greenleaf Jennifer , Karimzadeh Roghaiyeh , Park Yong-Lak
Published: November 2023

Glossy buckthorn (Frangula alnus) (Rosales: Rhamnaceae) is an invasive shrub from Europe that has been invading North America for over a century and threatening native vegetation in open and disturbed habitats. The treatment of F. alnus is currently restricted to the roadside, suggesting any individual F. alnus residing within the forest would be left unmanaged and would continue to spread in the area. This research was conducted to determine the spatial patterns and relationship of F. alnus with forest roads. The presence and density of F. alnus at 1412 sample points were recorded on four sites in the Allegheny National Forest, Pennsylvania, USA. Buffer analyses were conducted along roads to determine the relationship between F. alnus density and proximity to forest roads. Geostatistics and spatial analysis by distance indices (SADIE) were used to characterize the spatial pattern of F. alnus. Results of this study showed that F. alnus was spatially aggregated and resided beyond forest roads. Both the density and presence of F. alnus decreased as the distance from the forest road increased. These results imply the potential for precision management of F. alnus by locating and managing only where F. alnus presents.
A Validated LC-MS/MS Method for Performing Belatacept Drug Monitoring in Renal Transplantation
Authors: Chhun Stéphanie , Trauchessec Mathieu , Melicine Sophie , Nicolas Frédéric , Miele Agathe , Lukic Srboljub , Vilain Estelle , Amrouche Lucile , Lebert Dorothée , Anglicheau Dany , Tartour Eric , Zuber Julien
Published: November 2023

Belatacept, a CTLA4-Ig, was designed to prevent rejection and graft loss in kidney transplant recipients. This immunotherapy showed a long-term clinical benefit mainly on renal function and better glycemic control but was also associated with a higher number of severe infectious diseases, particularly CMV disease, and lymphoproliferative disease. Therapeutic drug monitoring usually guides the benefit–risk assessment of long-term immunosuppression. In this study, an analytical method by LC-MS/MS was developed in 20 microL of plasma for the belatacept quantification. Intra- and inter-assay precision and accuracy were lower than 20% for the limit of quantification, and 15% for higher concentrations. The method was implemented in our lab and provided data about the inter-variability (N = 108) and intra-variability (N = 33) of belatacept concentrations in kidney transplant recipients with a stable renal function, after conversion from a CNI- to a belatacept-based regimen.
Advances in Shape Memory Alloy-Based Reinforcement in Steel Structures: A Review
Authors: Shao Chenxi , Huang Yonghui
Published: November 2023

The utilization of shape memory alloys (SMAs) to reinforce steel structures has been proven to be an efficient and reliable method, the structural strengthening needs can be met without the need for tensioning equipment by activating the SMAs to generate restoring stresses. This paper firstly introduces the properties of SMA, and then presents the latest research progress, opportunities and challenges of SMA in the field of steel structural reinforcement, both in terms of basic components and applications. In terms of components, the construction forms and working mechanisms of Fe-SMA strips, SMA/CFRP composite patches and SMA dampers are introduced. On this basis, the application of SMA in steel structures reinforcement is introduced, and its effect is analyzed from three aspects: crack restoration, seismic retrofitting and structural strengthening. Finally, the results of the current research are summarized and the shortcomings are analyzed, hoping to provide a reference for the research of SMA in the field of steel structures reinforcement.
A Bibliometric Analysis on Pulsed Electrolysis: Electronic Effect, Double Layer Effect, and Mass Transport
Authors: Wang Zhuowen , Liu Yijun , Liu Sibei , Cao Yuxuan , Qiu Shan , Deng Fengxia
Published: November 2023

Pulsed electrolysis endowed merits of high current density, low energy consumption, and simple operation; thus, a booming in their publication numbers has been witnessed in recent years. In this review, we aim to summarize the state-of-the-art pulsed current/potential strategy to enhance electrochemical reactions, such as oxygen reduction reactions (ORR), CO2 reduction (CO2RR), CO reduction (COR), etc. It begins with historic analysis of pulsed electrolysis via a bibliometric method, aiming at providing a progress over the course of around 40 years in a quantitative way. Then, the definition along with its influence of electronic effect, double layer effect and mass transport have been reviewed based on a mechanism point of view for the first time. To sum up the review, several current challenges and future prospects of pulsed electrolysis have provided for the future smart design of electrochemical process.
Assessing Property Exposure to Cyclonic Winds under Climate Change
Authors: Shu Evelyn G. , Pope Mariah , Wilson Bradley , Bauer Mark , Amodeo Mike , Freeman Neil , Porter Jeremy R.
Published: November 2023

Properties in the United States face increasing exposure to tropical storm-level winds due to climate change. Driving this increasing risk are severe hurricanes that are more likely to occur when hurricanes form in the future and the northward shift of Atlantic-formed hurricanes, increasing the estimated exposure of buildings and infrastructure to damaging winds. The wind model presented here combines open data and science by utilizing high-resolution topography, computer-modeled hurricane tracks, and property data to create hyper-local tropical cyclone wind exposure information for the Contiguous United States (CONUS) from current time to 2053 under RCP 4.5. This allows for a detailed evaluation of probable wind speeds by several return periods, probabilities of cyclonic thresholds being reached or surpassed, and a comparison of this cyclone-level wind exposure between the current year and 30 years into the future under climatic changes. The results of this research reveal extensive exposure along the Gulf and Southeastern Atlantic Coasts, with significant growing exposure in the Mid-Atlantic and Northeastern regions of the country.
Correction: Lightburn, K.D. Can a Symbolic Mega-Unit of Radiative Forcing (RF) Improve Understanding and Assessment of Global Warming and of Mitigation Methods Using Albedo Enhancement from Algae, Cloud, and Land (AEfACL)? Climate 2023, 11, 62
Authors: Lightburn Kenneth D.
Published: November 2023

There were errors in the original publication [...]
Lung Cancer Staging: Imaging and Potential Pitfalls
Authors: Erasmus Lauren T. , Strange Taylor A. , Agrawal Rishi , Strange Chad D. , Ahuja Jitesh , Shroff Girish S. , Truong Mylene T.
Published: November 2023

Lung cancer is the leading cause of cancer deaths in men and women in the United States. Accurate staging is needed to determine prognosis and devise effective treatment plans. The International Association for the Study of Lung Cancer (IASLC) has made multiple revisions to the tumor, node, metastasis (TNM) staging system used by the Union for International Cancer Control and the American Joint Committee on Cancer to stage lung cancer. The eighth edition of this staging system includes modifications to the T classification with cut points of 1 cm increments in tumor size, grouping of lung cancers associated with partial or complete lung atelectasis or pneumonitis, grouping of tumors with involvement of a main bronchus regardless of distance from the carina, and upstaging of diaphragmatic invasion to T4. The N classification describes the spread to regional lymph nodes and no changes were proposed for TNM-8. In the M classification, metastatic disease is divided into intra- versus extrathoracic metastasis, and single versus multiple metastases. In order to optimize patient outcomes, it is important to understand the nuances of the TNM staging system, the strengths and weaknesses of various imaging modalities used in lung cancer staging, and potential pitfalls in image interpretation.
Benign and Malignant Oral Lesion Image Classification Using Fine-Tuned Transfer Learning Techniques
Authors: Islam Md. Monirul , Alam K. M. Rafiqul , Uddin Jia , Ashraf Imran , Samad Md Abdus
Published: November 2023

Oral lesions are a prevalent manifestation of oral disease, and the timely identification of oral lesions is imperative for effective intervention. Fortunately, deep learning algorithms have shown great potential for automated lesion detection. The primary aim of this study was to employ deep learning-based image classification algorithms to identify oral lesions. We used three deep learning models, namely VGG19, DeIT, and MobileNet, to assess the efficacy of various categorization methods. To evaluate the accuracy and reliability of the models, we employed a dataset consisting of oral pictures encompassing two distinct categories: benign and malignant lesions. The experimental findings indicate that VGG19 and MobileNet attained an almost perfect accuracy rate of 100%, while DeIT achieved a slightly lower accuracy rate of 98.73%. The results of this study indicate that deep learning algorithms for picture classification demonstrate a high level of effectiveness in detecting oral lesions by achieving 100% for VGG19 and MobileNet and 98.73% for DeIT. Specifically, the VGG19 and MobileNet models exhibit notable suitability for this particular task.
Many-Dimensional Model of Adolescent School Enjoyment: A Test Using Machine Learning from Behavioral and Social-Emotional Problems
Authors: Ali Farhan , Ang Rebecca P.
Published: November 2023

There is an emerging, many-dimensional model of human functioning that has yet to be rigorously tested in adolescent psychopathology. The model is based, in part, on research suggesting stronger predictive power at the level of single items compared to the commonly used smaller number of higher-level constructs represented by scores or factors. Here, the model is tested in research relevant for the understanding how psychopathology relates to adolescent school enjoyment. We compared, explained, and clustered machine learning model results from a set of 99 self-reported items from different instruments that measured the behavioral and social-emotional problems of adolescents to predict school enjoyment. There is support for a many-dimensional model. Individual items had unique variances beyond noise that incrementally added out-of-sample predictive power above construct-level prediction, particularly for nonlinear machine learning classifiers. Explainable machine learning uncovered important predictors of low school enjoyment, and these were specific nuances of withdrawn/depressive behaviors, elevated fears and anxieties, lowered sensation-seeking, and some conduct problems—what we term risk nuances (cf. risk factors). Clustering further identified shared risk nuances among different groups of individuals with low school enjoyment. Our results suggest that item nuances are important in revealing many ways in which adolescents’ behavioral and social-emotional problems relate to school enjoyment at the individual and group levels. A many-dimensional model can complement current descriptive, predictive, and intervention efforts in adolescent psychopathology.
Attribute-Based Encryption Scheme with k-Out-of-n Oblivious Transfer
Authors: Zhang Hao , Zhao Yue , Meng Jintao , Wang Xue , Wu Kaijun
Published: November 2023

Attribute-based encryption enables users to flexibly exchange and share files with others. In these schemes, users utilize their own attributes to acquire public-private key pairs from the key generation center. However, achieving this for users who wish to keep their attributes private poses a challenge. To address this contradiction, we propose an original scheme that combines ciphertext policy attribute-based encryption with a k-out-of-n oblivious transfer protocol. This scheme allows the distribution of corresponding public-private key pairs to users without the key generation center needing to obtain specific user attributes. Furthermore, it ensures the privacy of the key generation center. Security analysis demonstrates that the scheme is secure in the random oracle model. Our performance comparison and experimental results indicate that the scheme is both flexible and efficient.
Experimental Evaluation of the Deposition Dynamics of Different Petroleum Blends in a Benchtop Heat Exchanger Test Instrument
Authors: Villardi H. G. D. , de Medeiros F. F. , Orrico L. C. , de Souza A. L. B. , Junior I. M. , Liporace F. S. , Pessoa F. L. P.
Published: November 2023

The article delves into the intricate phenomenon of deposition in heat exchangers and how a piece of equipment known as the benchtop heat exchanger test instrument (BHETI) has been developed to expedite the examination of this phenomenon. The BHETI subjects samples to substantial stress, facilitating the assessment of an oil’s tendency to generate deposits. Tests were conducted on two crude oil blends referred to as blend A and blend B using a BHETI unit. This equipment permits testing under various controlled conditions, including temperature, pressure, and volumetric flow rate. The results indicated that blend A exhibited a higher susceptibility to deposition compared to blend B due to its elevated concentration of light hydrocarbons. The wall temperature exerted a significant influence on the deposition rate, with higher temperatures leading to elevated deposition rates. Conversely, lower oil flow rates resulted in increased deposition rates. Furthermore, extended-term tests unveiled fluctuations in deposition rates over time when blending the two oil samples, suggesting intermittent fouling processes, possibly attributable to thermodynamic imbalances induced by mixing, rendering the oil’s asphaltenes less stable. The outcomes were subjected to analysis employing the Colloidal Instability Index (CII), which indicated that the majority of samples exhibited values exceeding 0.9, signifying asphaltene instability. Additionally, the examination of saturated, aromatic, and NSO (nitrogen, sulfur, oxygen) fractions revealed decreased saturation and increased aromatics after the deposition tests.
Analysis of the Exothermic Reaction of Flame Ignition in the Combustion Chamber of a Gas Turbine Unit
Authors: Maspanov Sergej , Bogov Igor , Martynenko Svetlana , Sukhanov Vladimir
Published: November 2023

This article analyses the exothermic reaction of flame ignition in the combustion chamber of a gas turbine unit, which is characteristic of combustion chambers operating on traditional hydrocarbon fuels. The combustion of gases as an explosive process in confined and semi-enclosed areas remains a poorly understood section of thermal physics. Without a detailed review of the physical and chemical processes taking place in the combustion chamber, it cannot be said whether the gas turbine unit will run sustainably. It is also important to know what combustion modes are in principle possible after a loss of stability in the combustion chamber in order to take action against this in advance. To describe flame ignition and quenching in the flow of the fuel–air mixture through a combustion chamber, a system of differential conservation equations of energy and reactive species supplemented with the equation of state is used. Nonstationary combustion processes in gas-turbine engines were studied, and flame ignition and blow-off were determined by the heat balance and by the continuity of chemical processes. Calculation methodologies for various operating modes of the combustion chamber of a gas turbine unit are developed and realized. The results of the calculations that were carried out are presented with graphical interpretation and with their analysis provided in sufficient detail. Based on this analysis, recommendations are then provided. From the graphs, it can be observed that the combustion chamber of a gas turbine unit reaches its maximum limit of stable operation at the optimum value of the reduced flow velocity in the openings of the air supply to the combustion and the mixing zones of the flame tube (λOC)opt = 0.22 when the fuel–air mixture is at maximum depletion, ensuring that combustion does not stop and flame failure does not occur. The topic of this article relates to the intensification of hydrocarbon fuel combustion and the technological improvement of combustion chambers in gas turbine units. This topic is of exceptional importance and relevance, emphasizing its significance. The purpose of this work is to develop and implement a methodology for calculating various modes of operation of the combustion chamber of a gas turbine unit.
Carbon Sequestration by Soils of Ash Dump Forest Areas in the Middle Urals (Russia)
Authors: Nekrasova Olga , Radchenko Tatiana , Betekhtina Anna , Petrova Tatiana , Uchaev Anton , Dergacheva Maria
Published: November 2023

The purpose of this article was to assess the participation of young soils of ash dump forest communities in carbon sequestration by soils of southern taiga forests, considering the physico-chemical properties of the ash substrate and forest litter (pH, TOC, TN, content of P and K mobile compounds, and exchangeable Ca and Mg ions). It was revealed that on three Middle Ural ash dumps (composed of fly ash from various brown coals) over 50–60 years, forest communities spontaneously formed according to the zonal type (with the dominance of Betula pendula Roth and Populus tremula L.) with poorly differentiated young soils—technosols. For the first time, as a result of using an integrated approach to assess the direction of forest ecosystem formation on fly ash dumps, a tendency to increase carbon stocks in technogenic soils that have not reached the level of zonal soils was revealed, as well as the dependence of C accumulation on some physico-chemical characteristics of ash was established. Carbon stocks in Technosols are on average equal to 44 t/ha but vary significantly. It was shown that there is a medium negative relationship between the content and stocks of organic carbon in soils formed on a technogenic substrate and the content of mobile phosphorus compounds in them (the correlation coefficient is −0.58 and −0.53, respectively). The average carbon stocks in the litter of technosols, which is the main source of organic carbon in forest soils, are 3.2 t/ha. It was revealed that the carbon stocks in the litter are most influenced by the content of exchangeable calcium cations and magnesium in it (the correlation coefficients are −0.68 and −0.69, respectively). Any correlation between the studied litter parameters and carbon accumulation in the soils of ash dumps was found. The study revealed that the carbon stocks in the technosols of ash dump forest communities are two times less than the carbon stocks in the zonal forest soils of the Middle Ural southern taiga. The stocks of this element in the litter of young soils are equal to 1/3 of the litter of zonal soils. The composition of the humus substance system formed in the soils of forest areas of ash dumps and zonal soils is similar. The results of this study can serve to fill gaps in the knowledge about carbon sequestration by soils and aim to draw attention to forest communities of technogenic ecosystems to consider the contribution of their components to carbon sequestration.
Near-Infrared Spectroscopy Procedure for Online Determination of Sodium and Potassium Content in Low-Salt Cured Hams
Authors: Campos María Isabel , Debán Luis , Pardo Rafael
Published: November 2023

This paper reports the development of a near-infrared spectroscopy (NIRS) calibration procedure for the determination of sodium and potassium content in cured ham samples. Sliced samples of hams treated with different salts in different percentages were included in the study. Calibration models developed using partial least squares regression were cross-validated and predictive models were tested using the samples of cured ham with low sodium content. The results showed that the developed NIRS procedure is capable of directly measuring the potassium content of packaged dry-cured ham slices with low sodium content with a fitting accuracy of 91.44%, and that it can indirectly determine the sodium content by applying a correction factor to the values obtained for potassium. The prediction error between the calculated and actual sodium values determined using inductively coupled plasma atomic emission spectrophotometry (ICP-AES) was 0.004%, and this confirms that the NIRS procedure is a viable option for the determination of sodium and potassium content in this type of sample.
Case Report and Literature Review of Parvimonas micra: Difficult-to-Treat Arthritis in Hiding
Authors: Cenicacelaya Olabarrieta Xabier , Cabello Vallejo Margarita , Morell-Hita José Luis , Macía-Villa Cristina
Published: November 2023

Septic arthritis is a life-threatening rheumatological syndrome that is highly related to a patient’s immune status and comorbidities, and although the most common clinical presentation is rapid-onset monoarthritis, it can also appear as subacute or chronic joint swelling. In these cases, differential diagnosis is more challenging, but early diagnosis and treatment is no less urgent to ensure a good global prognosis and the best outcome of the affected joint. Anaerobic microorganisms, such as Parvimonas micra, are an uncommon cause of septic arthritis (less than 5% of cases) but may be the cause of subacute arthritis. Knowledge about Parvimonas micra is important, as it is difficult to culture in the laboratory and generates a synovial fluid with atypical characteristics for septic arthritis so that, if not suspected, its diagnosis can be easily overlooked and underdiagnosed. We present the case of a 76-year-old woman with subacute arthritis of the left knee, describe the difficult diagnosis and treatment of its unexpected cause (Parvimonas micra), and review previously described cases, identifying the possible common comorbidities that may help clinicians easily find and treat this cause of subacute septic arthritis.
Management and Outcomes of Invasive Procedures in Individuals with Hemophilia A on Emicizumab Prophylaxis: A Single Center Experience
Authors: Rener Karla , Anžej Doma Saša , Fink Martina , Podgornik Helena , Preložnik Zupan Irena
Published: November 2023

Prophylactic treatment with emicizumab has become an important and effective bleeding prevention for people with hemophilia A (PwHA). Perioperative management of PwHA using emicizumab prophylaxis is still challenging due to a lack of experience. Medical records of perioperative management and outcomes were reviewed, and data were collected for adult PwHA receiving emicizumab and undergoing surgical procedures between August 2019 and July 2022 at the University Medical Center Ljubljana. Twelve surgical procedures were performed in eight PwHA (one with FVIII inhibitors) while on emicizumab prophylaxis. Three minor procedures included cataract surgery, cystoscopic lithotripsy, and percutaneous coronary intervention. Nine major surgeries included four osteosyntheses, necrectomy of chronic osteomyelitis with new ankle arthrodesis, two below-knee amputations, total knee replacement, and placement of ventriculostomy after a spontaneous intraventricular hemorrhage. No major bleeds, thrombotic events or deaths, or new inhibitors appeared. Our real-world experience demonstrates that minor and major surgeries can be performed safely in PwHA on emicizumab prophylaxis. Additional data are needed to optimize dosing/duration of additional hemostatic agents in diverse invasive procedures and complex clinical situations.
The Sociocultural Influences on Breast Cancer Screening among Rural African Women in South Africa
Authors: Sarmah Nelisha , Sibiya Maureen Nokuthula , Khoza Thandokuhle Emmanuel
Published: November 2023

The incidence of breast cancer in South Africa is increasing, with rural South African women presenting with advanced stages of the disease. A woman’s breasts are a symbol of her womanhood; they also constitute a social definition of her femininity. Women with breast cancer in rural South Africa are heavily stigmatized and suffer from various sociocultural interpretations of the disease. Breast cancer is frequently interpreted in rural South Africa as a symbol of witchcraft, sin, and punishment, and traditionally, it is treated by offering animal sacrifices, consumption of herbs, and prayer to ancestors. Using care-seeking behaviour theory as the theoretical framework, we intend to explore the sociocultural factors influencing breast cancer screening practices among rural South African women. A qualitative exploratory study was conducted using semi-structured interviews with 22 rural South African women selected by purposive sampling. Thematic analysis was used to analyse the data. The study identified four sociocultural factors influencing women’s practices of breast cancer screening in rural South Africa, including psychological factors, habits, beliefs, and perceptions of healthcare. Women in rural South African communities have deep-rooted traditional beliefs and practices regarding breast cancer. Consequently, this influences women’s preventative health behaviours regarding breast cancer screening. The development of culturally appropriate health education programs involving traditional healers and influential community leaders is essential to increasing the number of women being screened for breast cancer in rural South Africa.