bluuebunny/crossref_metadata_2025 huggingface dataset:
An online glaucoma educational course for patients to facilitate remote learning and patient empowerment
Authors: Hamid Sana , Minakaran Neda , Igwe Chinedu , Baneke Alex , Pedersen Marcus , Mathew Rashmi G
Published: January 2024

In both face-to-face and teleophthalmology glaucoma clinics, there are significant time constraints and limited resources available to educate the patient and their carers regarding the glaucoma condition. Glaucoma patients are often not satisfied with the content and amount of information they receive and have demonstrated a substantial lack of knowledge regarding their condition. Innovative educational tools that facilitate accessible digital remote patient education can be a powerful adjunct to empower patients in becoming healthcare partners.

We describe the development of a free, comprehensive, multimodal online glaucoma patient education course for adults with glaucoma, their family and friends and carers, with the aim of providing a readable resource to aid remote learning and understanding of the condition.

The working group for the development of the course comprised of consultants, medical practitioners and education specialists and expert patients. Given the specialised nature of ophthalmology and glaucoma, certain aspects can be difficult to conceptualise, and, therefore, clear and adequate explanations of concepts are provided in the course using diagrams, flow charts, medical illustrations, images, videos, written text, analogies and quizzes.

The course is available in a short and long version to suit different learning needs which take approximately 2 hours and 10 hours to complete respectively. The contents list allows course takers to find sections relevant to them and it can be taken anywhere, as long as there is Internet access.

We invite you to share this resource with your patients and their families, friends and carers.
Proof-of-concept solution to create an interoperable timeline of healthcare data
Authors: Trivedi Sapna , Hall Stephen , Inglis Fiona , Chaudhry Afzal
Published: January 2024

Objectives

To overcome the barriers of interoperability by sharing simulated patient data from different electronic health records systems and presenting them in an intuitive timeline of events.

Methods

The ‘Patient Story’ software comprising database and blockchain, PS Timeline Windows interface, PS Timeline Web interface and network relays on Azure cloud was customised for Epic and Lorenzo electonic patient record (EPR) systems used at different hospitals, using site-specific adapters.

Results

Each site could view their own clinical documents and view each other’s site specific, fully coded test sets of (Care Connect) medications, conditions and allergies, in an aggregated single view.

Discussion

This work has shown that clinical data from different EPR systems can be successfully integrated and visualised on a single timeline, accessible by clinicians and patients.

Conclusion

The Patient Story system combined the timeline visualisation with successful interoperability across healthcare settings, as well giving patients the ability to directly interact with their timeline.
Assessing the efficient use of the lightwave health information management system for health service delivery in Ghana
Authors: Agyemang Edward , Esia-Donkoh Kobina , Boateng Adu-Gyamfi Addae , Douri Juabie Bennin , Adoma Prince Owusu , Achampong Emmanuel Kusi
Published: January 2024

Background

In achieving the WHO’s Universal Health Coverage and the Global Developmental Agenda: Sustainable Development Goal 3 and 9, the Ministry of Health launched a nationwide deployment of the lightwave health information management system (LHIMS) in the Central Region to facilitate health service delivery. This paper assessed the efficient use of the LHIMS among health professionals in the Central Region.

Methods

A non-interventional descriptive cross-sectional study design was employed for this research. The study used stratified and simple random sampling for selecting 1126 study respondents from 10 health facilities that use the LHIMS. The respondents included prescribers, nurses, midwives and auxiliary staff. Descriptive statistics (weighted mean) was computed to determine the average weighted score for all the indicators under efficiency. Also, bivariate (χ2) and multivariate (ordinal logistic regression) analyses were conducted to test the study’s hypotheses.

Results

Findings revealed that the LHIMS enhanced efficient health service delivery. From the bivariate analysis, external factors; sex, educational qualification, work experience, profession type and computer literacy were associated with the efficient use of the LHIMS. However, training offered prior to the use of the LHIMS, and the duration of training had no association. At the multivariate level, only work experience and computer literacy significantly influenced the efficient use of the LHIMS.

Conclusion

The implementation of LHIMS has the potential to significantly improve health service delivery. General computing skills should be offered to system users by the Ministry of Health to improve literacy in the use of computers. Active participation in the use of LHIMS by all relevant healthcare professionals should be encouraged.
ChatGPT in Iranian medical licensing examination: evaluating the diagnostic accuracy and decision-making capabilities of an AI-based model
Authors: Ebrahimian Manoochehr , Behnam Behdad , Ghayebi Negin , Sobhrakhshankhah Elham
Published: January 2024

Introduction

Large language models such as ChatGPT have gained popularity for their ability to generate comprehensive responses to human queries. In the field of medicine, ChatGPT has shown promise in applications ranging from diagnostics to decision-making. However, its performance in medical examinations and its comparison to random guessing have not been extensively studied.

Methods

This study aimed to evaluate the performance of ChatGPT in the preinternship examination, a comprehensive medical assessment for students in Iran. The examination consisted of 200 multiple-choice questions categorised into basic science evaluation, diagnosis and decision-making. GPT-4 was used, and the questions were translated to English. A statistical analysis was conducted to assess the performance of ChatGPT and also compare it with a random test group.

Results

The results showed that ChatGPT performed exceptionally well, with 68.5% of the questions answered correctly, significantly surpassing the pass mark of 45%. It exhibited superior performance in decision-making and successfully passed all specialties. Comparing ChatGPT to the random test group, ChatGPT’s performance was significantly higher, demonstrating its ability to provide more accurate responses and reasoning.

Conclusion

This study highlights the potential of ChatGPT in medical licensing examinations and its advantage over random guessing. However, it is important to note that ChatGPT still falls short of human physicians in terms of diagnostic accuracy and decision-making capabilities. Caution should be exercised when using ChatGPT, and its results should be verified by human experts to ensure patient safety and avoid potential errors in the medical field.
Signal processing and machine learning algorithm to classify anaesthesia depth
Authors: Mosquera Dussan Oscar , Tuta-Quintero Eduardo , Botero-Rosas Daniel A.
Published: January 2024

Background

Poor assessment of anaesthetic depth (AD) has led to overdosing or underdosing of the anaesthetic agent, which requires continuous monitoring to avoid complications. The evaluation of the central nervous system activity and autonomic nervous system could provide additional information on the monitoring of AD during surgical procedures.

Methods

Observational analytical single-centre study, information on biological signals was collected during a surgical procedure under general anaesthesia for signal preprocessing, processing and postprocessing to feed a pattern classifier and determine AD status of patients. The development of the electroencephalography index was carried out through data processing and algorithm development using MATLAB V.8.1.

Results

A total of 25 men and 35 women were included, with a total time of procedure average of 109.62 min. The results show a high Pearson correlation between the Complexity Brainwave Index and the indices of the entropy module. A greater dispersion is observed in the state entropy and response entropy indices, a partial overlap can also be seen in the boxes associated with deep anaesthesia and general anaesthesia in these indices. A high Pearson correlation might be explained by the coinciding values corresponding to the awake and general anaesthesia states. A high Pearson correlation might be explained by the coinciding values corresponding to the awake and general anaesthesia states.

Conclusion

Biological signal filtering and a machine learning algorithm may be used to classify AD during a surgical procedure. Further studies will be needed to confirm these results and improve the decision-making of anaesthesiologists in general anaesthesia.
Electronic health record intervention to increase use of NSAIDs as analgesia for hospitalised patients: a cluster randomised controlled study
Authors: Bongiovanni Tasce , Pletcher Mark J , Robinson Andrew , Lancaster Elizabeth , Zhang Li , Behrends Matthias , Wick Elizabeth , Auerbach Andrew
Published: January 2024

Background

Prescribing non-opioid pain medications, such as non-steroidal anti-inflammatory (NSAIDs) medications, has been shown to reduce pain and decrease opioid use, but it is unclear how to effectively encourage multimodal pain medication prescribing for hospitalised patients. Therefore, the aim of this study is to evaluate the effect of prechecking non-opioid pain medication orders on clinician prescribing of NSAIDs among hospitalised adults.

Methods

This was a cluster randomised controlled trial of adult (≥18 years) hospitalised patients admitted to three hospital sites under one quaternary hospital system in the USA from 2 March 2022 to 3 March 2023. A multimodal pain order panel was embedded in the admission order set, with NSAIDs prechecked in the intervention group. The intervention group could uncheck the NSAID order. The control group had access to the same NSAID order. The primary outcome was an increase in NSAID ordering. Secondary outcomes include NSAID administration, inpatient pain scores and opioid use and prescribing and relevant clinical harms including acute kidney injury, new gastrointestinal bleed and in-hospital death.

Results

Overall, 1049 clinicians were randomised. The study included 6239 patients for a total of 9595 encounters. Both NSAID ordering (36 vs 43%, p<0.001) and administering (30 vs 34%, p=0.001) by the end of the first full hospital day were higher in the intervention (prechecked) group. There was no statistically significant difference in opioid outcomes during the hospitalisation and at discharge. There was a statistically but perhaps not clinically significant difference in pain scores during both the first and last full hospital day.

Conclusions

This cluster randomised controlled trial showed that prechecking an order for NSAIDs to promote multimodal pain management in the admission order set increased NSAID ordering and administration, although there were no changes to pain scores or opioid use. While prechecking orders is an important way to increase adoption, safety checks should be in place.
Hemorrhagic Shock from a Duodenal Ulcer Eroding into an Ectopic Varix
Authors: Singh Harjit , Kimchy Alexandra , Boustani Camille , Umoren Mfoniso , Rangnekar Amol , Smith Coleman
Published: January 2024

Ectopic varices are an infrequent yet fatal complication resulting from the progression of liver cirrhosis. Duodenal varices pose a significant challenge to clinicians as they are not easily visualized on endoscopy due to their submucosal location and lack of red color signs. Identification of duodenal varices is important given the risk of massive and life-threatening bleeding that is difficult to control. Patients may present in hemorrhagic shock requiring immediate resuscitation; however, confirmation of the bleeding source as variceal or non-variceal is critical in determining the optimal therapeutic intervention. Here, we report an unusual case of a duodenal ulcer that eroded into an ectopic varix resulting in hemorrhagic shock.
Microplastics in the Ecosystem: A Systematic Review of the Methods for Their Detection and Removal
Authors: Rubiños Santiago L. , Grados Juan H. , Medina Juan T. , Chávez Eduardo N. , Huarcaya Edwin , Rocha Victor E. , Grados Herbert J. , Neyra Milagros R.
Published: January 2024

Currently, research on microplastics (MPs) has increased due to their rapid distribution throughout the world and their harmful effects on the ecosystem. However, a detailed description of their dispersion and the methods for both detection and removal has not been given. The objective of this research is to carry out a bibliographic review that allows for a multidisciplinary analysis of microplastic contamination and current detection and removal methods. The method used is PRISMA in which articles from reliable databases such as Scopus, Web of science, and Google Scholar were collected and analyzed to finally provide details on the physical and chemical methods for detecting MPs, in addition to presenting the technologies for their removal. As a result of the analysis, critical information was obtained from the different studies on the impact of MPs on the ecosystem and the variation in detection and removal efficiency according to the type of pretreatment and methods applied to the sample. It is concluded that this research is essential to understand the consequences that MPs have on the ecosystem and provide tools to evaluate and improve current technologies, mainly detection and removal.
A Denoising Algorithm Combined with EMD and LMS for Precise Transmission Signal
Authors: Song Lei , Cao Yongjun , Zhou Yushan , You Dongdong
Published: January 2024

High accuracy and stability in mechanical transmission are crucial for various applications. In spite of the validity of mechanical enhancements, control algorithms’ fulfilment offers a cost-effective and efficient approach to mitigating the effects of noise signals. This study presents a hybrid algorithm that combines EMD with the least mean square (LMS) error to achieve online denoising. Within the algorithm, consecutive mean square error (CMSE) and the l2-norm metric are employed to assess the similarity between intrinsic mode functions (IMFs) and the original signal; therefore, IMFs are separated into three distinct components: noise components, information components, and mixed components. The denoised signal is obtained by partial reconstruction. Subsequently, the denoised signal is employed as a reference signal in the LMS algorithm, which is utilized for practical processing. The performance evaluation of the developed algorithm employs simulation and experimental signals. The obtained results illustrate that the presented approach achieves sufficient accuracy and stability.
Searching for a “Window of Opportunity” in the Treatment of Vulvar Lichen Sclerosus: Evidence for Therapeutic Benefits of an Early Corticosteroid Treatment
Authors: Borghi Alessandro , Flacco Maria Elena , Schettini Natale , Toni Giulia , Corazza Monica
Published: January 2024

Introduction: Vulvar lichen sclerosus (VLS) is characterized by progressive anatomical changes which become increasingly severe and irreversible. The objective of this study was to investigate if a “window of opportunity” exists in VLS, i.e., to assess if an early treatment may prevent disease progression and facilitate clearance of symptoms and/or signs. Methods: This retrospective, cohort study included VLS patients treated for the first time with a topical corticosteroid, namely with mometasone furoate 0.1% ointment, for 12 weeks (2016–2021). Scoring of subjective symptoms (global subjective score, GSS, and dyspareunia) and clinical features (global objective score [GOS] and sclerosis-scarring-atrophy) was performed at baseline (T0) and at the control visit (T1). We assessed if the achievement of clearance in GSS, GOS, sclerosis-scarring-atrophy, or dyspareunia depended on the time elapsed between VLS onset and treatment initiation. Results: Among the 168 patients (59.2 ± 13.2 years) included, the median time between VLS onset and first treatment was 14.0 months. At T1, 48.8% of patients achieved clearance of GSS, 28% of GOS and 11.9% of both GSS and GOS, 57.9% of dyspareunia, and 19.2% of sclerosis-scarring-atrophy. The logistic regression model showed that each 10-month increase in treatment initiation adversely affected the clearance of GSS while starting treatment within 6 months of disease onset was significantly associated with clearance of GOS and sclerosis-scarring-atrophy. Conclusion: Early treatment is crucial in determining a complete healing of VLS-related symptoms and signs, especially of tissue sclerosis-scarring-atrophy, which appear poorly responsive, or even unresponsive, after the earliest stages of the disease. Thus our findings provide evidence for a “window of opportunity” in VLS treatment.
Association of Higher N-3 Polyunsaturated Fatty Acid Consumption and Aerobic Exercise with Lower Neutrophil-to-Lymphocyte Ratio: Implications of Anti-Atherosclerotic Effect of Fish Consumption
Authors: Tani Shigemasa , Imatake Kazuhiro , Suzuki Yasuyuki , Yagi Tsukasa , Takahashi Atsuhiko
Published: January 2024

Introduction: N-3 polyunsaturated fatty acids (n-3 PUFAs), abundant in oily fish, exert anti-inflammatory cardiovascular protective effects. We aimed to investigate the association between fish-derived n-3 PUFAs, lifestyle habits, and neutrophil-to-lymphocyte ratio (NLR), an atherosclerotic cardiovascular disease (ASCVD) marker. Methods: This cross-sectional study included 6,950 participants with no history of ASCVD, who underwent annual health check-ups (average age, 46.3 ± 13.0 years; male:female ratio, 58.8%) between April 2019 and March 2020 at the Health Planning Center, Nihon University Hospital. We calculated n-3 PUFA consumption using a questionnaire and the Japan National Health and Nutrition Survey. Results: The average fish consumption frequency and fish-derived n-3 PUFA consumption were 2.20 ± 1.28 days/week and 5.20 ± 3.11 g/week, respectively. A higher fish-derived n-3 PUFA consumption was associated with a lower NLR. Multiple-stepwise regression analysis revealed that higher fish-derived n-3 PUFA consumption and more aerobic exercise habits were significant independent determinants of lower NLR. Furthermore, higher fish-derived n-3 PUFA consumption was associated with habitual aerobic exercise habits. Conclusion: Thus, higher fish-derived n-3 PUFA consumption and more aerobic exercise habits may be synergistically associated with lower NLR. This association may explain the preventive effects of fish consumption on the ASCVD risk.
Ecuadorian Acanthocinini: description of two new species and transference and notes on Sympagus cooperi Monné & Monné
Authors: VLASAK JOSEF , SANTOS-SILVA ANTONIO
Published: January 2024

Two new Acanthocinini are described from Ecuador: Nealcidion apunctatum sp. nov.; and Xenocona nubicola sp. nov. Sympagus cooperi Monné & Monné, 2017 is transferred to Stenolis Bates, 1864, and notes on the differences between these two genera are provided.
Sol-gel fabricated one-dimensional LiFePO4 microstructures for carbon nanotube-based nanocomposite freestanding sheet as cathode material for Li ion batteries
Authors: Al Shibli Hamda , Chaturvedi Prerna , Kanagaraj Amarsingh Bhabu , Zaghari Pouria , Choi Daniel S , Ryu Jong Eun
Published: January 2024

Lithium Iron Phosphate (LiFePO4) microstructures have been synthesized using the sol-gel process. One-dimensional (1D) LiFePO4 microstructures were fabricated using tissue paper as a template under different temperatures to form pure phase microstructures. XRD analysis confirmed the single phase nature of orthorhombic olivine-structured LiFePO4 with Pnma space group. SEM analysis authenticated the formation of 1D LiFePO4 microstructures along with some clusters of particles. LiFePO4-multi-walled carbon nanotubes (MWCNT) freestanding sheets were prepared using a tape-casting process. Further, the electrochemical properties of LiFePO4-MWCNT freestanding sheet were analyzed through electrochemical impedance spectroscopy, cyclic voltammetry, and galvanostatic charge-discharge analysis.
Organizing Sustainably: Introduction to the Special Issue
Authors: Delbridge Rick , Helfen Markus , Pekarek Andreas , Schuessler Elke , Zietsma Charlene
Published: January 2024

To confront the climate crisis requires fundamental system change in order to break the convention of relentless economic exploitation of nature. In this Special Issue we extend understanding of the opportunities for an organizing perspective on sustainability in order that organization studies might contribute more effectively to the challenges of organizing sustainably. This organizing perspective is particularly sensitive to (1) a variety of forms and practices of sustainable organizing in different societal spheres and on different levels, (2) the social institutions, logics and value systems in which these forms and practices are embedded, (3) the power and politics of promoting (or blocking) sustainable organization, and (4) the ways in which work, voice, participation, and inclusion are organized and contribute to developing societal capabilities. These features formed the basis of our original call for papers and we review selected literature on sustainability, including the contribution of organization studies and the articles in this Special Issue, through this organizing perspective. In so doing we identify four key themes of a future research agenda that builds from the foundations of existing research and addresses key current limitations in both theory and practice: sustainability requires social justice; connecting local and global scale shifts; democratizing governance; and acting collectively. We conclude with some implications for our own scholarship in organization studies if we are to meet the twin challenges of the need for new theorizing in combination with devising practically relevant support for change.
Association Between Draft Order and Stress Sonography of the Ulnar Collateral Ligament of the Elbow in Professional Baseball Pitchers: An 18-Year Study
Authors: Hanna Adeeb J. , Sonnier John H. , Fliegel Brian E. , Sherman Matthew B. , Ciccotti Michael G. , Jack Robert A. , Cohen Steven B.
Published: January 2024

Background:

The Major League Baseball (MLB) draft is a common route for players to enter professional baseball in the United States. Players taken in earlier rounds are typically higher-performing players. When looking at pitchers specifically, higher performance at the amateur level may be associated with an increased frequency of adaptive change in the throwing elbow.

Purpose:

To determine whether pitchers taken in earlier rounds of the MLB draft have a greater frequency or extent of pathological change in the elbow, as measured by dynamic stress ultrasound.

Study Design:

Cross-sectional study; Level of evidence, 3.

Methods:

Dynamic stress ultrasounds (SUSs) were performed over 18 years on the dominant and nondominant arms of 651 professional pitchers. The 383 drafted players were grouped according to the round in which they were drafted (rounds 1-5, 6-10, 11-20, 21+). Groups were compared with respect to “relative” ulnar collateral ligament (UCL) thickness (dominant-nondominant), relative ulnohumeral joint laxity (joint space distance under stress minus joint space at rest), and the presence of pathology (calcifications, tears, hypoechoic foci, osteophytes). In addition, a subgroup analysis was done to compare the progression of SUS findings over 3 years in players for which data were available.

Results:

Draft round groups did not differ by age, number of previous spring training, or handedness. Comparing baseline measurements, there was no significant relationship between draft round and relative UCL thickness ( P = .932), relative laxity ( P = .996), or presence of pathology detectable on SUS ( P = .642). However, increased relative UCL thickness was significantly associated with the presence of pathology on SUS (odds ratio, 1.45; 95% CI, 1.26-1.69; P < .001). Longitudinally, there was no significant relationship between draft round and 3-year progression of relative laxity, relative UCL thickness, or clinical progression of pathology.

Conclusion:

Higher-performing pitchers are drafted earlier in the MLB draft. This may be attributable to peak pitch velocity, in-game performance, visibility gained during player showcases, or any number of other sport-specific variables. However, despite this, there was no significant relationship between draft round and adaptive changes to the elbow or specific properties of the UCL on stress ultrasound.
Intermediate-Term Outcomes of Hip Arthroscopy for Femoroacetabular Impingement Syndrome in Patients With Global Versus Isolated Lateral Acetabular Overcoverage
Authors: Kingery Matthew T. , Akpinar Berkcan , Rynecki Nicole D. , Campbell Hilary T. , Lin Lawrence J. , Youm Thomas
Published: January 2024

Background:

Previous studies evaluating the outcomes of hip arthroscopy for patients with global acetabular overcoverage and focal superolateral acetabular overcoverage suffer from short-term follow-up and inconsistent radiographic criteria when defining these subpopulations of patients with femoroacetabular impingement syndrome (FAIS).

Purpose:

To evaluate the intermediate-term postoperative outcomes for patients with FAIS in the setting of global acetabular overcoverage, lateral acetabular overcoverage, and normal acetabular coverage.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

Patients undergoing hip arthroscopy for FAIS were enrolled in a prospective cohort study, and those with a minimum follow-up of 5 years were included in this analysis. Patients were grouped based on type of acetabular coverage: global overcoverage (lateral center-edge angle [LCEA] ≥40°, with coxa profunda), lateral overcoverage (LCEA ≥40°, without coxa profunda), and no overcoverage (LCEA <40°). Functional outcomes (modified Harris Hip Score and Nonarthritic Hip Score) and failure of primary hip arthroscopy were compared between groups.

Results:

In total, 94 patients (mean age, 41.9 ± 14.2 years) were included with a mean follow-up duration of 6.1 ± 0.9 years. Of these patients, 40.4% had no acetabular overcoverage, 36.2% had lateral overcoverage, and 23.4% had global overcoverage. There was no difference between groups with respect to percentage of patients who underwent reoperation for either revision arthroscopy or conversion to total hip arthroplasty (28.9% for the normal acetabular coverage group, 29.4% for the lateral overcoverage group, and 31.8% for the global overcoverage group; P = .971). Among patients for whom primary hip arthroscopy did not fail, there was no difference in 5-year functional outcomes between groups. Postoperative LCEA >40° (β = −13.3; 95% CI, –24.1 to −2.6; P = .016), female sex (β = −14.5; 95% CI, –22.7 to −6.2; P = .001), and higher body mass index (β = −1.9; 95% CI, –2.8 to −1.0; P < .001) were associated with worse intermediate-term hip function in terms of modified Harris Hip Score.

Conclusion:

There was no difference in functional outcomes or rate of reoperation at a minimum of 5 years postoperatively between those with global acetabular overcoverage, those with regional lateral overcoverage, and those with normal acetabular coverage. Provided that an appropriate acetabuloplasty is performed, there is no evidence to suggest that global acetabular overcoverage portends a worse prognosis than other FAIS subtypes.
Where Does Firearm-Related Violence Occur in Cities?
Authors: Ceccato Vania , Westman Jorun
Published: January 2024

This article reviews five decades of literature in English investigating the nature of locations where most firearm-related violence occurs in public places, with a focus on neighbourhood-level and land-use characteristics. A search for peer-reviewed articles in Scopus, Web of Science and PubMed from 1970 to 2022 resulted in 112 articles. A bibliometric followed by a thematic analysis of the articles shed light on two questions: Which types of neighbourhood characteristics attract firearm-related violence? and What are the typical land uses associated with firearm-related violence? The article concludes by reporting examples from research of safety interventions implemented to tackle firearm violence.
Likes vs. Loves (and Other Emoji Reactions): Facebook, Women, and the Gender Emoji Gap in US Election Campaigns
Authors: Phillips Justin Bonest
Published: January 2024

In 2017, Facebook’s news feed algorithm began weighting emoji reactions (e.g., love and angry) as five times more valuable than the like button. Such a change is theoretically intriguing because existing research largely suggests that women tend to use emojis more than men on social media. Within the context of political campaigns, prior work has revealed a host of other “gender gaps,” from documenting men’s and women’s differing tolerance for negative campaigns, to examining variations in online political participation and—more broadly—charting gendered imbalances in party demographic support. To date, however, no study has looked to investigate this potential gender emoji gap within the online political environment. This paper explores just such a gap, combining data across three US election cycles (2016–2020), over thirty million individual observations, and thousands of (federal and state) candidates. The data shows that women exhibited a greater preference for emoji reactions than men in response to posts from the 2016 presidential election candidates. Party, and candidate negativity, also appeared to moderate this effect. Likely due to this (moderated) gender gap, Democratic candidates continued to see a much higher proportion of emoji reactions to their posts, than Republicans in 2018, and 2020. In turn, the results offer clear evidence of a persistent emoji gender gap in US political campaigns on Facebook. Such findings strengthen our theoretical understanding of political communication and behavior online, and prompt important questions going forward for future research.
Working experience of nurse anesthetists with beneficence for patients
Authors: Panaso Chontira
Published: January 2024

Background

Nowadays, patients in Thailand have easier access to public health services, resulting in an increased number of patients undergoing surgery. Therefore, the Royal College of Anesthesiologists produces nurse anesthetists to reduce the shortage of anesthesiologists who can perform general anesthesia under the physician’s supervision. As a result, nurse anesthetists must have the consciousness to work on the basis of ethics and professional standards. Nurse anesthetists have work experience that aims to benefit patients and make them as safe as possible.

Objective

To investigate the working experience of nurse anesthetists with beneficence for patients.

Methods

This study employed qualitative research using in-depth interviews. The sample consisted of 33 nurse anesthetists who volunteered to participate in the research project with more than ten years of work experience and worked in tertiary care hospitals. The researcher used a qualitative content analysis method. Ethical considerations: Study after approval and certification of the research project from the Human Ethics Committee of Mahidol University, and Naval Medical Department.

Results

The working experience of nurse anesthetists with beneficence for patients involves communicating and listening with compassion, being considerate, knowledgeable, and standard operations, team communication, and awareness of patient safety, as a productive and non-harmful work experience.

Discussion

Nurse anesthetists working in situations of beneficial approaches to patient care need experience in appropriate communication, professional knowledge and skills to thoroughly assess patients, pass critical information to the team, and be aware of potential risks. Make patients receive care in a more suitable and safe way.

Conclusion

Working experience of nurse anesthetists with beneficence for patients exists with communication and listening with compassion, being considerate, communicating and forwarding the patient’s necessary information to the team to be aware of abnormalities, knowledgeable and standard operations, and awareness of patient safety in every phase of the performance consistently.
Functional Communication Training Including Discrimination and Tolerance to Denial for Elementary Age Students With Autism
Authors: Snyder Sara K. , Herrod Jessica L. , Whiteside Erinn E. , Ayres Kevin M.
Published: January 2024

Functional communication training (FCT) provides an efficient means for reducing a variety of challenging behaviors while increasing social communication. After establishing a functional communication response (FCR), interventionists may need to design a program to thin the schedule of reinforcement to provide more durable effects and maintenance in the natural environment. Hanley et al. provided one means for thinning schedules that involved the systematic introduction of extinction (or denial trials) following a process of delaying reinforcement. This study evaluates a southeastern U.S. classroom application of this thinning process with three elementary age students who engaged in a variety of aggression, self-injury, disruption, and crying. The results indicate positive effects of the FCT program with systematic introduction of denial trials once the participants demonstrated proficiency with the FCR. In addition, data for two participants show prolonged effects post-intervention. Results are discussed in terms of extending Hanley et al. and how these procedures can be used within typical school-based settings.
Not All That Post, Not All That New: The Disruption of Challenging Coloniality
Authors: Serra Undurraga Jacqueline Karen Andrea , Wyatt Jonathan
Published: January 2024

What happens when, as scholars who have habitually been working with posthumanism and the new materialisms, we find ourselves summoned by thinkers who critique the covert coloniality present in these approaches? This work is the result of a year-long project where we set up the task of feeling our way through these critiques, exploring how they change our work and ourselves; and attempting to find a way of relating to the challenge of decoloniality. We use collaborative writing as an approach to delve into our encounters with readings, our own histories, and our ways of relating to the academy and each other. In this work, we start from our differing histories and positionalities—a Chilean woman and a British man; now colleagues and with a history of being a PhD supervisee-supervisor. Then, we grapple with how posthumanism/new materialism has neglected to think about how coloniality is entangled in who the “humans” it speaks to are and how it is further reproducing colonial dynamics of ethnocentric erasure that effectively do not allow it to go beyond the “human.” After considering possibilities of integration, reparation, survival, and refusal, we conclude it is crucial to reflexively acknowledge and work with our concrete positionalities and interests, thereby making our conceptualizations necessarily provincial, limited, and in some ways problematic. Otherwise, we run the risk of engulfing decolonial, postcolonial, anticolonial, and indigenous theories without any fundamental change, thus furthering coloniality.
Peritoneal Dialysis-Associated Peritonitis Caused by Achromobacter xylosoxidans: A Case Report and Literature Review
Authors: Tawhari Ibrahim , Saggese Samantha , Alshahrani Shatha S. , Asiri Ghufran , Alshahrani Shatha A. , Summan Sarah , Al Qasim Yousef Y. , Al Majbar Yahya A.
Published: January 2024

Achromobacter xylosoxidans is a gram-negative bacterium that is responsible for rare peritonitis associated with peritoneal dialysis (PD). We present a case of a 64-year-old woman with a medical history of end-stage renal disease undergoing PD who was admitted to the emergency department with abdominal pain and nausea. Physical examination and laboratory studies revealed peritoneal signs and laboratory abnormalities consistent with peritonitis. Intraperitoneal catheter dysfunction was identified and subsequently resolved via laparoscopy. Following a peritoneal fluid culture, A xylosoxidans was identified, leading to the initiation of intraperitoneal meropenem treatment. After an initial improvement, the patient developed an ileus and recurrent abdominal symptoms, and further peritoneal cultures remained positive for A xylosoxidans. Subsequent treatment included intravenous meropenem and vancomycin for Clostridium difficile colitis. Owing to the high likelihood of biofilm formation on the PD catheter by A xylosoxidans, the catheter was removed, and the patient transitioned to hemodialysis. Intravenous meropenem was continued for 2 weeks post-catheter removal. This case highlights the challenges in managing recurrent peritonitis in PD patients caused by multidrug-resistant A xylosoxidans. A high index of suspicion, appropriate microbiological identification, and targeted intraperitoneal and systemic antibiotic treatment, along with catheter management, are crucial in achieving a favorable outcome in such cases.
The ACT in Health Activism: Teaching Street Theater to College Students
Authors: Mullany Anna L.
Published: January 2024

Street theater is historically a form of political performance art used to foster social change and is characterized by unscheduled performances in public spaces, interactive audience participation, and short performances often repeated in the same spot for passersby. Long used as a creative tool within social movements, street skits not only entertain but are used to educate and build awareness on pressing issues. It is an art form for the people, by the people, making theater available for all (“on the streets”) rather than solely for those who can afford it. Street theater also has its uses in public health education and organizing and has been used globally as an effective method of health promotion, especially in rural and low-literacy areas. This paper looks at a street theater project that university students at Clark University in Worcester, MA participated in as part of a “Health Rights: Advocacy and Action” course. Students were tasked with developing a street theater skit that educates on a public health issue and publicly perform the skit on campus. Three skits were produced: (1) “Deadly Derailment”: raised awareness on industry deregulation and the 2023 toxic chemical spill in East Palestine, OH; (2) “Harm Reduction Saves Lives”: addressed humane and non-victim blaming ways to address substance use; and (3) “End the STIgma”: educated on sexual health on a college campus. Teaching street theater as part of public health pedagogy is a creative approach to inspire students to use their voices and link health promotion and activism.
Experimental-based numerical simulation of interacting suspended ceiling-sprinkler piping systems
Authors: Soroushian Siavash , Rezvani Razieh , Zaghi Arash E , Maragakis Manos
Published: January 2024

Suspended ceiling and fire sprinkler piping (CP) systems are two of the most common interacting nonstructural elements inside the buildings. While each of these elements individually is prone to losses during the earthquakes, their interaction can even more intensify their associated damage. This article aims to integrate system-level modeling methodology by using existing subsystem-level models in OpenSees platform to simulate the interacting behavior of CP systems. To do so, the numerical model of the CP systems is developed by using a series of previously developed component-level nonlinear models. Experimental results from a shake table study of CP systems installed in a five-story building (fully scaled) are used for the validation of the proposed methodology. Experimental acceleration and displacement responses of CP systems at different locations as well as the damage-progression pattern in the suspended ceiling system are predicted well through the use of the proposed modeling technique.
Thrombospondin-1 is an endogenous substrate of cereblon responsible for immunomodulatory drug–induced thromboembolism
Authors: Hatakeyama Kiwamu , Kikushige Yoshikane , Ishihara Daisuke , Yamamoto Shunsuke , Kawano Gentaro , Tochigi Taro , Miyamoto Toshihiro , Sakoda Teppei , Christoforou Andy , Kunisaki Yuya , Fukata Mitsuhiro , Kato Koji , Ito Takumi , Handa Hiroshi , Akashi Koichi
Published: January 2024

Immunomodulatory drugs (IMiDs) are key drugs for treating multiple myeloma and myelodysplastic syndrome with chromosome 5q deletion. IMiDs exert their pleiotropic effects through the interaction between cell-specific substrates and cereblon, a substrate receptor of the E3 ubiquitin ligase complex. Thus, identification of cell-specific substrates is important for understanding the effects of IMiDs. IMiDs increase the risk of thromboembolism, which sometimes results in fatal clinical outcomes. In this study, we sought to clarify the molecular mechanisms underlying IMiDs-induced thrombosis. We investigated cereblon substrates in human megakaryocytes using liquid chromatography–mass spectrometry and found that thrombospondin-1 (THBS-1), which is an inhibitor of a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs 13, functions as an endogenous substrate in human megakaryocytes. IMiDs inhibited the proteasomal degradation of THBS-1 by impairing the recruitment of cereblon to THBS-1, leading to aberrant accumulation of THBS-1. We observed a significant increase in THBS-1 in peripheral blood mononuclear cells as well as larger von Willebrand factor multimers in the plasma of patients with myeloma, who were treated with IMiDs. These results collectively suggest that THBS-1 represents an endogenous substrate of cereblon. This pairing is disrupted by IMiDs, and the aberrant accumulation of THBS-1 plays an important role in the pathogenesis of IMiDs-induced thromboembolism.
Defining the impact of immune tolerance induction on clinically relevant outcomes in a US cohort of severe hemophilia A
Authors: Kempton Christine L. , Fedewa Stacey A.
Published: January 2024

Although the near-term benefit of immune tolerance induction (ITI) for the treatment of people with severe hemophilia A with inhibitor is apparent, the magnitude of the longer-term impact of ITI on clinical outcomes remains undefined. We examined the association between receiving ITI and the success of ITI on clinical outcomes including (1) clinical events, (2) health care use, (3) quality of life/function, (4) socioeconomic status, and (5) death, using the Community Counts (CC) registry of US Hemophilia Treatment Centers between 2013 and 2017. Multivariate logistic regression, negative binomial, and Poisson models were used. Included in this study were 3659 people with severe hemophilia A with median age of 21 years when entering the CC registry. Among 576 participants with inhibitors, 485 had received ITI (84%). ITI was successful in 299 (61.7%) and partially successful or failed in 95 (19.5%) or 91 (18.7%), respectively. Those that received ITI had fewer treated bleeds, less chronic pain, better function, and higher educational attainment than those not receiving ITI. Successful vs partially successful and failed ITI was associated with fewer treated bleeds, less health care use, less chronic pain, better function, and fewer missed days of school or work. Mortality was not associated with ITI, regardless of its success. Those with successful ITI had similar rates of treated bleeds, chronic pain, and health care use as those with no inhibitors. Undergoing ITI, particularly if successful, improved clinical outcomes but not mortality. These findings support decision making regarding initiation of ITI and inform future clinical trials.
MHESMMR: a multilevel model for predicting the regulation of miRNAs expression by small molecules
Authors: Guan Yong-Jian , Yu Chang-Qing , Li Li-Ping , You Zhu-Hong , Wei Meng-meng , Wang Xin-Fei , Yang Chen , Guo Lu-Xiang
Published: January 2024

According to the expression of miRNA in pathological processes, miRNAs can be divided into oncogenes or tumor suppressors. Prediction of the regulation relations between miRNAs and small molecules (SMs) becomes a vital goal for miRNA-target therapy. But traditional biological approaches are laborious and expensive. Thus, there is an urgent need to develop a computational model. In this study, we proposed a computational model to predict whether the regulatory relationship between miRNAs and SMs is up-regulated or down-regulated. Specifically, we first use the Large-scale Information Network Embedding (LINE) algorithm to construct the node features from the self-similarity networks, then use the General Attributed Multiplex Heterogeneous Network Embedding (GATNE) algorithm to extract the topological information from the attribute network, and finally utilize the Light Gradient Boosting Machine (LightGBM) algorithm to predict the regulatory relationship between miRNAs and SMs. In the fivefold cross-validation experiment, the average accuracies of the proposed model on the SM2miR dataset reached 79.59% and 80.37% for up-regulation pairs and down-regulation pairs, respectively. In addition, we compared our model with another published model. Moreover, in the case study for 5-FU, 7 of 10 candidate miRNAs are confirmed by related literature. Therefore, we believe that our model can promote the research of miRNA-targeted therapy.
Dating ancient splits in phylogenetic trees, with application to the human-Neanderthal split
Authors: Levinstein Hallak Keren , Rosset Saharon
Published: January 2024

Background

We tackle the problem of estimating species TMRCAs (Time to Most Recent Common Ancestor), given a genome sequence from each species and a large known phylogenetic tree with a known structure (typically from one of the species). The number of transitions at each site from the first sequence to the other is assumed to be Poisson distributed, and only the parity of the number of transitions is observed. The detailed phylogenetic tree contains information about the transition rates in each site. We use this formulation to develop and analyze multiple estimators of the species’ TMRCA. To test our methods, we use mtDNA substitution statistics from the well-established Phylotree as a baseline for data simulation such that the substitution rate per site mimics the real-world observed rates.

Results

We evaluate our methods using simulated data and compare them to the Bayesian optimizing software BEAST2, showing that our proposed estimators are accurate for a wide range of TMRCAs and significantly outperform BEAST2. We then apply the proposed estimators on Neanderthal, Denisovan, and Chimpanzee mtDNA genomes to better estimate their TMRCA with modern humans and find that their TMRCA is substantially later, compared to values cited recently in the literature.

Conclusions

Our methods utilize the transition statistics from the entire known human mtDNA phylogenetic tree (Phylotree), eliminating the requirement to reconstruct a tree encompassing the specific sequences of interest. Moreover, they demonstrate notable improvement in both running speed and accuracy compared to BEAST2, particularly for earlier TMRCAs like the human-Chimpanzee split. Our results date the human – Neanderthal TMRCA to be$$\sim 408,000$$∼408,000years ago, considerably later than values cited in other recent studies.