bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Meditasi Musik Sufistik terhadap Kualitas Kesadaran Spiritual Santri
Authors: Yana Lusi
Published: February 2023

Abstrak

               

The Effect of Sufistic Music Meditation on the Quality of Spiritual Awareness of Santri. In fact, Islamic boarding schools are also starting to experience the same crisis. Balancing one side is an important thing. Therefore this research is important to study so that it can be seen its significance to the problems that occur. This study aims to find out: 1) Does Sufistic music meditation affect the quality of the spiritual awareness of the students? 2) Are there any differences between the experimental group and the control group? To reveal this, a quantitative approach to the experimental pre-post control group design was used. This research is aimed at 20 students who live in PP. Annuqayah Lubangsa Selatan Putri. The final conclusions from the results of this study are: 1) There is an effect of Vx on Vy with a Paired Sample test of 0.041 <0.05, then Ha is accepted. 2) There is no significant difference between the two groups with Independent Sample results of 0.260 and 0.261> 0.05, then from these results H0 is accepted.

Keywords: Santri, Meditation, Music, Sufistik, Spiritual Awareness
THE DIFFERENCES IN INTERPRETATION OF THE HADITH: A Study of The Hadith al-Jannatu tahta Aqdam al-Ummahat
Authors: Huda Miftahul
Published: February 2023

The study of the differences in the interpretation of the hadith about heaven under the soles of the mother’s feet, aims to examine and analyze the differences in views and debates of the scholars as well as the method of understanding the hadith on heaven under the soles of the mother’s feet (al-jannatu tahta aqdam al-ummahat) contextually. In this study, the method used is qualitative literary study with an analytic-descriptive approach. As for the data analysis using qualitative descriptive analytics, namely describing and analyzing the hadith about al-jannatu tahta aqdam al-ummahat. The results of this study indicate that the status of the hadith about heaven under the soles of the mother’s feet gives rise to two statuses, namely authentic and dhaif. As narrated from Mu’awiyah bin Jahimah, he concluded that the hadith had the status of authentic. Whereas what was narrated by Anas bin Malik with a different path and proof, is declared to have the status of dhaif. The debate of hadith scholars in understanding this hadith is more directed at disputes about hadith narrations with various methods and approaches used, namely the sanad, narrator, and language methods. From the different views of scholars regarding this hadith, it does not lead to the substance of the hadith in question, which commands to do good to parents. This hadith positions a woman (mother) is in Islam as a highly glorified figure.

[Kajian mengenai perbedaan dalam penafisran hadis tentang surga di bawah telapak kaki ibu, bertujuan untuk mengkaji dan menganalisa perbedaan pandangan dan perdebatan para ulama serta metode memahami hadis surga di bawah telapak kaki ibu (al-jannatu tahta aqdam al-ummahat) secara kontekstual. Dalam penelitian ini metode yang digunakan yaitu kualitatif bersifat studi kepustakaan dengan pendekatan desktiptif analitik. Adapun analisis data menggunakan kualitatif deskriptif analitik yaitu mendeskripsikan dan menganalisis hadis tentang surga di bawah telapak kaki ibu (al-jannatu tahta aqdam al-ummahat). Hasil penelitian ini menunjukkan bahwa status hadis tentang surga dibawah telapak kaki Ibu menimbulkan dua status yaitu shahih dan dhaif. Seperti yang diriwayatkan dari Mu’awiyah bin Jahimah, ia menyimpulkan bahwa hadis tersebut berstatus shahih. Sedangkan yang diriwayatkan oleh Anas bin Malik dengan jalur dan hujjah berbeda, yaitu dinyatakan berstatus dhaif. Perdebatan para ulama hadis dalam memahami hadis ini lebih mengarah pada perselisihan riwayat hadis dengan berbagai metode dan pedekatan yang digunakan yaitu metode sanad, rawi serta bahasa.  Dari perbedaan pandangan para ulama dan cendikiawan mengenai hadis tersebut, tidak mengarah kepada substansi hadis ini yang memerintahkan untuk melakukan berbuat baik kepada orang tua. Hadis ini memposisikan seorang perempuan (ibu) dalam Islam sebagai sosok yang sangat dimuliakan.]
Development of Three-Tier Test Instrument Based on Scientific Literacy in Electrolyte and Non-Electrolyte Solution Topics
Authors: Dewi Aulia Mirta , Haryani Sri
Published: February 2023

The scientific literacy is very important for students as a provision to face the challenges of the 21st century. The scientific literacy of students in Indonesia is low. One of the factors which causes students' scientific literacy tend to be low is that students have not been trained in answering questions with typical as on PISA. Efforts to train students to be familiar with scientific literacy include developing test instruments based on scientific literacy. This study aims to examine the feasibility and characteristics of the scientific literacy test instrument for electrolyte and non-electrolyte solutions; besides, examine the profile of students' scientific literacy abilities. The type of this study was Research & Development with a 4D model which includes the stages: define, design, develop, and disseminate. The research subjects were students of class X Science SMAN 1 Sragen. The results of the study show that (1) the scientific literacy test instrument which is developed is feasible and valid to be used with a validity of 34 of 35 questions which is declared valid and reliability of 0.86; (2) the characteristics of the test instrument is that using three aspects of scientific literacy in one question at once and can be used to determine the student's scientific literacy profile well; (3) the profile of students' scientific literacy skills is in a fairly good criterion with a percentage of 59%. The profile of students' scientific literacy abilities from the aspect of scientific competence is obtained as much as 57.21%; 59.72%; and 60.46%.
Analysis of Science Literacy Teaching Book Class XI at SMA Negeri Surakarta on Acid-Base Material
Authors: Pertiwi Nanda Putri , Nurhayati Nanik Dwi , Saputro Sulistyo
Published: February 2023

This descriptive research aims to explain the scope of scientific literacy in chemistry textbooks used in Surakarta. This research data are in the form of quantity from 4 categories of scientific literacy with 26 subcategories as indicators of grouping text units in textbook analysis. The data sources in this study were five textbooks for class XI with different publishers. The technique of taking the object of research uses a purposive sampling technique. Based on the results of data analysis based on the category of scientific literacy, the average results of the proportion of scientific literacy are obtained as follows: (1) Science as a body of knowledge was 69.98% (2 ) Science as a way of an investigation by 14.43% (3) Science as a way of thinking by 10.63% (4) Interaction of science with technology and society by 4.98%. The results of the fulfilment of the scientific literacy category in book A have a ratio of the category of science as knowledge: science as a way of investigation: interaction of science, technology, and society: category of science as a way of thinking that is 9:1:1:1. The ratio in book B is 6:2:0:1, the ratio in book C is 4:2:0:1, the ratio in book D is 9:0:0:1, and the ratio in book E is 6:2:1: 1. Therefore, from the results of this study, the recommended textbook for use is the book E because it includes aspects of scientific literacy that are complete and more balanced than the other four books.
Inorganic Chemistry Textbook-Integrated Science and Religion as Characteristics of Islamic Higher Education
Authors: Syamsuri M. Mahfudz Fauzi , Fadiawati Noor
Published: February 2023

Nowadays, studies related to the integration between religion and science were attracting the interest of many researchers from religious universities in order to confirm the paradigm of the general public about the dichotomy between religion and science. This study used the ADDIE instructional design to develop an inorganic chemistry textbook that was integrated with science and religion, describing the textbook's characteristics as well as responses from lecturers and students about the developed textbook. This textbook's features are based on chemical representations (macroscopic, submicroscopic, and symbolic) and are integrated with Qur’an verses and research findings. Validators have given an excellent assessment of the aspects of construction, readability, content suitability, and presentation of the material from the developed textbook with percentages of 100%, 92.5%, 96.88%, and 88.57%, respectively. Lecturers have responded favorably to aspects of content suitability and presentation, as well as attractiveness and usefulness. The graphic aspect, as well as the attractiveness, have elicited very positive responses from students. Based on this, the developed textbooks could be approved for use.
Interactive Multimedia by Stimulating Visual-Spatial Intelligence Trial
Authors: Ainyn Qurrota , Dwiningsih Kusumawati
Published: February 2023

Covalent bonding is an abstract and unobservable therefore it is necessary to develop interactive multimedia which present visualization in three dimension (3D) as an aid to represent unobservable matter. This study focuses on investigating the effectiveness of interactive multimedia by stimulating visual spatial intelligence on the covalent bond that has been developed. This study is according to the Research and Development model based on Sugiyono’s model including finding potential & problem, collecting data, product design, product validation, product revision and limited to product trials (Stage 6). The effectiveness of interactive multimedia is examined from the improvement of student learning outcomes after using interactive multimedia.  N-gain results shows that interactive multimedia was effective to enhance learning outcomes. The results showed that 81.2% of students in high category and 18.2% in the medium category. This study shows that there is an increase in student learning outcomes after using interactive multimedia by stimulating visual-spatial intelligence
Mapping Waqf Research: Bibliometric Analysis
Authors: Rosyidah Norma , Hidayati Athi'
Published: February 2023

The purpose of this study is to examine Indonesia's waqf development pattern. Waqf-related research includes, among other things, the study of waqf law, productive waqf schemes, empowering waqf for poverty, stock waqf, and waqf connected to sukuk. The most popular articles are frequently those that discuss how waqf can reduce poverty and promote economic empowerment. Studies on the professionalism of waqf institutions in Indonesia are relatively few. A review of the literature on the management of waqf institutions in favor of professionalism was done by the researchers in light of this. This study is a quantitative investigation that makes use of bibliometric analysis. A quantitative strategy for examining bibliographic information in papers and journals is called bibliometrics. In this study, a waqf journal that Google Scholar has indexed served as the population. Publish or Perish 8 was used to select the samples for this study, which were publications with the keywords "management of waqf institutions," "waqf institutions," and "professionalism of Nazhir" in Indonesia. The information demonstrated an increase in the number of publications since the average year. According to Google Scholars, there were 82, 89, 110, 141, 147, 143, and 195 more publications about endowment per year from 2015 to 2021. The research's key themes were the effects of waqf on the role of nazhirs, effective waqf management, and nazhir certification. Future research plans are anticipated to concentrate on the professional behavior of waqf institutions and how to best foster professionalism through waqf institutions. In Indonesian waqf institutions, there is a level of professionalism known as nazhir certification. This study is intended to advance waqf research both domestically and internationally so that waqf research can expand with new topics and become more diverse.
Plan de negocios para la producción de truchas en el departamento de Junín para su comercialización en Lima moderna
Authors:   , Barba Walters Claudia Sofia , Chapoñan Evangelista Joel , Cisneros Moya Eder , Navarro Llocya Mercedes Geraldine , Seras Zamudio Emerson Junior
Published: February 2023

Nuestro Perú destaca en el rubro de la producción de trucha en diversos puntos del país, entre uno de los departamentos que desarrollan dicha actividad se ubica en Puno, Huancavelica, Pasco y Junín. La trucha es una especie de pescado proveniente de la familia salmónidos, es un pez de agua dulce ubicado exclusivamente en la zona alto andina del país, los ríos en esta zona reúnen todas las condiciones necesarias que les permite desarrollarse adecuadamente. Nuestro presente proyecto de investigación expondrá el nivel de producción de trucha en el departamento de Junín para su posterior comercialización en la zona limeña exactamente nos ubicaremos en Lima Moderna. El nivel de consumo de trucha se ha mantenido en una alta tendencia durante todos estos últimos años, se toma en cuenta la importancia en la búsqueda por parte del consumidor de un producto de origen natural y de fácil accesibilidad para su consumo y/o adquisición. La trucha es una especie que se encuentra presente en el mercado nacional, sin embargo, encontramos diversos factores positivos y negativos que intervienen en el proceso. Como objeto de investigación desarrollaremos un análisis interno y externo que influye en nuestro estudio a fin de poder identificar la viabilidad de nuestro estudio. Nuestra investigación no solo determinara factores que influyen en la comercialización de truchas para su posterior consumo, además de ello brindaremos soluciones actuales que influirán de manera positiva en la correcta toma de decisión por el consumidor, satisfaciendo lo que busca nuestro público objetivo a través del uso e implementación de nuestro estudio de mercado, plan de marketing, análisis económico y financiero que impactará en el mercado actual.
Diseño de un plan de negocio para la creación de una empresa de blockchain en el departamento de Lima
Authors:   , Ávalos Cortez Julia Elisa , Taco Gamion Luis , Estrella Ramírez Carla Alexandra
Published: February 2023

La evolución tecnológica ha obtenido tantos logros en ámbitos tan inimaginables, que le han permitido situarse en podio para marcar el ritmo del proceso de evolución de las empresas y en consecuencia del ser humano a nivel individual. Por lo tanto, la tecnificación constante y el diseño de estrategias a futuro que permita a las empresas ser más competitivas en un mercado, supone un reto para las empresas como consecuencia de la globalización de la economía. Hoy en día se ofrece toda una diversidad de servicios, que van desde lo financiero, hasta la implementación de carteras digitales, donde los principios como la sostenibilidad, la transparencia y la tecnología son esenciales en cada uno de los procesos. Actualmente se está produciendo un cambio de paradigma en el funcionamiento de las empresas, donde la alineación de la contabilidad y la tecnología blockchain son herramientas valiosas y eficaces para alcanzar estos objetivos y disponer de información precisa, trazable e inmediata para comunicarla y utilizarla en la toma de decisiones en el futuro.
Relación entre marketing mix y desempeño exportador en empresas exportadoras de arándanos frescos a Estados Unidos, 2021
Authors:   , Alarcon Luyo Danixa , Quispe Santos Olenka Brilly
Published: February 2023

El objetivo principal de este estudio era determinar la relación entre la combinación de comercialización y los resultados de exportación de las empresas que exportaron arándanos frescos a EE.UU. en 2021. Se trató de un estudio cuantitativo de ruta, con un diseño transversal, no experimental, de tipo básico. Las empresas exportadoras de arándanos frescos a EE.UU. conformaron la población, que ascendió a 54 empresas cuando se utilizó la base de datos del segundo semestre de 2021. Se seleccionaron 39 empresas como base para el muestreo de conveniencia no probabilístico. Se utilizaron dos escalas tipo Likert como herramientas de medición y una encuesta para recopilar los datos. La validez interna y la validez de contenido de la herramienta de investigación se determinaron a partir del criterio de jueces expertos y del estadístico de fiabilidad "alfa de Cronbach", que arrojaron valores de 0,986 y 0,995, respectivamente, lo que indica que la herramienta presenta una fiabilidad extremadamente adecuada. Los resultados revelaron una significación estadística de 0,000 y un coeficiente de correlación de 0,548 entre la mezcla de marketing y el rendimiento de las exportaciones en las empresas que exportan arándanos frescos a Estados Unidos en 2021, según la prueba estadística rho de Spearman. Asimismo, en las empresas que exportan arándanos frescos a Estados Unidos en 2021, se constató que existe una relación positiva y significativa entre la combinación de comercialización y el rendimiento de las exportaciones.
Resistencia a la tracción en dentina con sellado dentinario inmediato unida a una resina bis-acrílica: un estudio in vitro
Authors:   , Castro Ruiz Rodrigo
Published: February 2023

Introducción: La co-polimerización de dobles enlaces residuales presente en la capa inhibida de oxígeno puede causar la adhesión química del material provisional en la superficie del sellado dentinario inmediato (SDI). Objetivo: Comparar la resistencia a la tracción en dentina con sellado dentinario inmediato unida a una resina bis-acrílica utilizando glicerina en gel y agua destilada en spray para el tratamiento de la capa inhibida de oxígeno. Metodología: 45 incisivos centrales y laterales inferiores bovinos con SDI unidos a la resina bis-acrílica Protemp (3M ESPE) distribuidos en 3 grupos según el tratamiento de la capa inhibida de oxígeno: (Control: Adhesivo Single Bond Universal (3M ESPE), Unidad LED Elipar Deep Cure-S (3M ESPE). G1: Glicerina (KY), Agua destilada (Matraz). G2: Agua destilada), seguido del test de tracción con la máquina de ensayos universales (CMT-5L; LG; 7419; Corea) a una velocidad de 1 mm/min respecto a la formula RU = F / A. Resultados: G1 mostró el promedio más alto de resistencia a la tracción (3,42 ± 0,302), seguido por Control (1,71 ± 0,152) y G2 (1,26 ± 0,131), el Post-Hoc de Tukey mostró diferencias significativas (p=0,0001) entre todos los grupos. Conclusiones: G2 presentó el promedio de resistencia a la tracción más bajo (1,26 ± 0,131), siendo la técnica más eficaz para reducir la resistencia a la tracción del material provisional al SDI.
Remoción de cromo (VI) de agua residual de curtiembre empleando materia orgánica vegetal (MOV), en un reactor biológico secuencial (RBS) aerobio
Authors:   , Camacllanqui Huamanlazo Alex Orestes
Published: February 2023

[Objetivo]: Utilizar materia orgánica vegetal (MOV) en un reactor biológico secuencial (RBS) aerobio, como fuente de remoción de Cromo (VI), en el tratamiento de aguas residuales de curtiembre. [Metodología]: Se implementó 3 sistemas RBS aerobios; 2 controles (RBS1 y RBS2) y uno materia de estudio (RBS+MOV), todas alimentadas con agua residual de curtiembre y conectados a un sistema de aireación. El lodo, fundamental para el funcionamiento de los sistemas RBS, se obtuvo a partir del cultivo selectivo de bacterias reductoras de Cromo (VI) (BRCrVI) tomadas del agua residual en estudio, e integradas al RBS2 y RBS+MOV. La MOV se obtuvo a partir de la fragmentación de Stenotaphrum secundatum, tamizado, esterilizado e integrado al RBS+MOV. [Resultados]: El sistema SRB+MOV alcanzó el mayor porcentaje de remoción de Cromo (VI) (93 %), seguido por SBR2 (80.1 %), y por último RBS1 (2.8 %). Con respecto a la DQO y SST, la prueba estadística (Tukey) arrojó que no había diferencia significativa entre el sistema en estudio y los controles, alcanzando porcentajes de remoción de DQO que van de 87.8 % a 88.4 %, y SST que van de 63.8 % a 69.2 %. [Conclusiones]: Se ha evidenciado la capacidad de la MOV dentro de un sistema RBS aerobio, como una alternativa ambientalmente eficiente en la remoción de Cromo (VI), en el tratamiento de aguas residuales de curtiembre. Además, su uso no representa en lo mínimo un aumento de DQO y SST al final del tratamiento.
Signature Based V2X Communication and Authentications Using Resourceful Signcryption and Optimised Ecc
Authors: Priyanka j , M Ramakrishnan
Published: February 2023

Vehicular ad hoc networks (VANETs) serve as the backbone of the intelligent transportation system, connecting vehicles together (ITS). VANET is becoming more and more popular as the number of vehicles that are capable of interacting with one another grows. When a vehicle comes within radio transmission range of the message source or another informed vehicle, it can receive the message and be notified of its location and status. In VANET the communication has been done by V2V, V2I and V2X, since wireless networks are available, maintaining communication protection and privacy has become a major challenge for VANETs. A method of protecting the privacy of automobiles in vehicular ad hoc networks (VANs) was proposed in the study. There has been various research carried out to secure communication on VANET. In this work the secure communication has been designed with the Optimised ECC as well as Signcryption with duple pseudonyms generator. This signature-based protocol to upgrade the master key in regular interval to avoid impersonation attacks and threats to identity privacy. The work has been analysis with the other efficient protocol over VANET simulation environment with the performance metrics of beacon overhead, authentication delay and Unknown Neighbouring ratio. The efficiency of the Optimised Elliptic curve Signcryption compared with the other related work.
Kirschner wires as blocking screws technique in extra-articular fractures of the distal tibia treated with intramedullary nail
Authors: liu jun , Huang Wenzhou , Dai Simin , Xie Lifeng , Deng Hui , Yang Peng , Tao Jun , Gao Guicheng
Published: February 2023

Background
To explore the clinical efficacy and safety of Kirschner wires (KW) as blocking screws technique in extra-articular fractures of the distal tibia treated with intramedullary nail (IMN).
Methods
61 patients treated with IMN for extra-articular fractures of the distal tibia assisted with KW as blocking screws technique or Poller screws (PS) technique. The operation time, times of fluoroscopy, number of blocking screws used, blood loss and time to union were compared between the two groups. Also, the functional outcomes of the two groups were compared using range of motion (ROM), visual analogue scale (VAS), American Orthopedic Foot and Ankle Society (AOFAS), and Lysholm scores.
Results
Compared with the PS group, the operation time of the KW group was significantly shorter, the times of fluoroscopy and the amount of blood loss during the surgery of KW were also significantly reduced (P < 0.05). Regarding the functional outcomes, there were no significant differences in ROM, VAS, AOFAS and Lysholm scores between the two groups (P > 0.05).
Conclusion
In the treatment of extra-articular fractures of the distal tibia with nails, KW as blocking screws technique is safe and reliable.
Distinct CSF biomarker-associated DNA methylation in Alzheimer's disease and cognitively normal subjects
Authors: Zhang Wei , Young Juan I. , Gomez Lissette , Schmidt Michael A. , Lukacsovich David , Varma Achintya , Chen X. Steven , Martin Eden R. , Wang Lily
Published: February 2023

Background
Growing evidence has demonstrated that DNA methylation (DNAm) plays an important role in Alzheimer's disease (AD) and that DNAm differences can be detected in the blood of AD subjects. Most studies have correlated blood DNAm with the clinical diagnosis of AD in living individuals. However, as the pathophysiological process of AD can begin many years before the onset of clinical symptoms, there is often disagreement between neuropathology in the brain and clinical phenotypes. Therefore, blood DNAm associated with AD neuropathology, rather than with clinical data, would provide more relevant information on AD pathogenesis.
Methods
We performed a comprehensive analysis to identify blood DNAm associated with cerebrospinal fluid (CSF) pathological biomarkers for AD. Our study included matched samples of whole blood DNA methylation, CSF Aβ42, phosphorylated tau181 (pTau181), and total tau (tTau) biomarkers data, measured on the same subjects and at the same clinical visits from a total of 202 subjects (123 CN or cognitively normal, 79 AD) in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. To validate our findings, we also examined the association between premortem blood DNAm and postmortem brain neuropathology measured on a group of 69 subjects in the London dataset.
Results
We identified a number of novel associations between blood DNAm and CSF biomarkers, demonstrating that changes in pathological processes in the CSF are reflected in the blood epigenome. Overall, the CSF biomarker-associated DNAm is relatively distinct in CN and AD subjects, highlighting the importance of analyzing omics data measured on cognitively normal subjects (which includes preclinical AD subjects) to identify diagnostic biomarkers, and considering disease stages in the development and testing of AD treatment strategies. Moreover, our analysis revealed biological processes associated with early brain impairment relevant to AD are marked by DNAm in the blood, and blood DNAm at several CpGs in the DMR on HOXA5 gene are associated with pTau181 in the CSF, as well as tau-pathology and DNAm in the brain, nominating DNAm at this locus as a promising candidate AD biomarker.
Conclusions
Our study provides a valuable resource for future mechanistic and biomarker studies of DNAm in AD.
Bidirectional Generation of Structure and Properties Through a Single Molecular Foundation Model
Authors: Chang Jinho , Ye Jong Chul
Published: February 2023

Despite the impressive successes of deep learning approaches for various chemical problems such as property prediction, virtual screening, and de novo molecule design, separately designed models for specific tasks are usually required, and it is often difficult to synergistically combine these models for novel tasks. To address this, here we present a bidirectional molecular foundation model that can be used for both molecular structure and property inferences through a single model, inspired by recent multimodal learning methods such as VLP. Furthermore, thanks to the outstanding structure/property alignment in a common embedding space, experimental results confirm that our method leads to state-of-the-art performance and interpretable attention maps in both multimodal and unimodal tasks, including conditional molecule generation, property prediction, molecule classification, and reaction prediction.
The first report of the isotope-derived feeding ecology of copepods in the eastern Arabian Sea
Authors: D’souza Analiza , Gauns Mangesh , Bardhan Pratirupa , Kurian Siby
Published: February 2023

The seasonal variations of δ15N and δ13C of copepods and suspended particulate organic matter is examined to comprehend the feeding habits of copepods of the marine food web over the western continental shelf of India. This study provides baseline information on seasonal variation of the isotopic composition in copepods. Seasonal divergence in δ15N and δ13C values in Paracalanidae, Oncaeidae, Subeucalanus spp., Acartia spp. and Temora spp. conspicuously revealed herbivorous/omnivorous feeding habit. Such omnivorous feeding habit of copepods seems to play important role in trophodynamics of zooplankton and transfer of carbon and nitrogen to other trophic levels over the western continental shelf of India.
Introducing Digital Pathology in Fast-Frozen Section by Validating the Whole Slide Imaging Scanner Slideview VS200 Research Slide Scanner
Authors: Williams Julie Margaret , Noack Jeppe , Zeuthen Mette Christa , Necip Filis , Qvist Camilla C.
Published: February 2023

Background: The implementation and usage of digital pathology has undergone a huge development in recent years however the area of intraoperative consultation has not yet become digitized or fully investigated. The aim of this study was to explore the possibilities to digitize this area and consistency between the diagnoses based on the digital slides versus the traditional microscope. The whole slide image scanner Olympus VS200 STL proclaimed that it would be able to scan glass slides with wet mounting glue.
Method: To find the optimal scanning profile a field of four different scan profiles was tested in different contexts. The chosen profile was used to generate 126 digital slides from 60 cases. These slides were assessed on three parameters; compliance between diagnosis of the digital and traditional method, compliance with the visual quality and could the scan time including operating time be completed within 180 seconds pr slide.
Results: The overall result showed no deviation between diagnoses made with conventional microscope and the digital slide in 83% of the cases and the average operation time were 92.5 seconds.
Conclusion: Olympus VS200 STL has the potential to become implemented in a clinical pathology department for use in intraoperative diagnostics without affecting workflow, diagnostic accuracy, and acceptable timeframe (180 seconds pr slide).
Gasless robot-assisted transaxillary hemithyroidectomy (RATH): learning curve and complications
Authors: Xu Pengfei , Fang Qi , Mai Junhao , Zhao Zheng , Cao Fei , Wu Di , Liu Xuekui
Published: February 2023

Purpose: Gasless robot-assisted transaxillary hemithyroidectomy (RATH) is regarded as an alternative surgical option for thyroid operations. However, the associated steep learning curve is a clinical concern. This study evaluated the learning curve of RATH for surgeons without experience of endoscopic surgery and the early surgical outcomes of RATH.
Methods: We conducted a retrospective study of patients who underwent gasless RATH and conventional hemithyroidectomy (CH) at Sun Yat-sen University Cancer Center, Guangzhou, China, from June 2021 to August 2022. The learning curve and early surgical outcomes of gasless RATH were evaluated. And the early surgical outcomes of gasless RATH were compared to CH.
Results: In total, 105 patients who underwent gasless RATH and 104 patients who underwent CH were matched and assessed. The cumulative sum techniques (CUSUM) analysis showed that the peak point of gasless RATH operative time occurred at the 31st case. No clear single peak was identified in the CUSUM plot for drainage amount and blood loss. No significant difference in perioperative complications was observed between these two groups. Moreover, the number of postoperative patients who got sense of thyroid area traction were fewer in the gasless RATH group (n=11, 10.5%) than in the CH group (n=32, 30.8%).
Conclusion: Gasless RATH can be considered as an alternative approach to the conventional open procedure, as it is an easy remote access technique, with shorter learning curves and certain advantage such as less sense of thyroid area traction.
Complex mathematical statements useful as criterion for Landau-Siegel Zeros
Authors: louiz akram
Published: February 2023

This is a mathematical article that deals with the domain of complex numbers in order to contribute in the worldwide collaboration of mathematicians who want to study and explain the Riemann's Zeta Function.
The aim of this work is to propose new mathematical statements of complex numbers and to give a new easy criterion that may help to identify or deny the possible Landau-Siegel Zeros. Furthermore, this work invites the mathematicians to study a new possible useful homomorphism.
Hence, this is a good article to be read by specialists of Analysis or Algebra and even by the beginners of mathematics who want to improve their skills.
Micromechanical analysis of magnetoelectric coupling of composites containing nonlinear magnetostrictive and piezoelectric constituents
Authors: Lin Chien-hong , Lin Chung-Yi
Published: February 2023

This paper is a reformulation of the simplified unit-cell and Mori-Tanaka micromechanics theories in their applications to nonlinear magnetoelectric analysis of two-phase 0-3, 1-3 and 2-2 composites. We elucidate the similarity between the two models insofar as concentration-factor matrices are concerned. The representations of the bulk magnetostrictive and piezoelectric phases are based on nonlinear constitutive equations. Due to material nonlinearity, the mathematical frameworks are accomplished via incremental formulation that provides a system of linear algebraic equations at each increment which is obviously a great advantage over nonlinear one. The derived nonlinear composite constitutive relations that govern the hysteresis behavior of composites are implemented to study the composite composed of Terfenol-D and PZT constituents. The responses of this composite to a complete cycle of magnetic field are shown and the micromechanics predictions are compared in light of existing experimental data.
Optimization of Standard Reference Cerebral Ventricular Volumes Measuring Protocol using Magnetic Resonance Imaging Techniques for Clinical Applications
Authors: Issahaku Shirazu , Dapaah Isaac , Tiburu Elvis. k. , Dapaah ken , Sackey Theophilus A.
Published: February 2023

Introduction

Cerebral ventricular morphology and morphometric changes in response to some ensuing cerebral pathological processes. These changes may be use as an indication to detect pathological processes. Thus, it is imperative to establish a measuring procedure to measure very vital organ dimensions to aid clinal diagnoses and to optimize these procedures for clinical application. In addition to establishing baseline data of ventricular volumes to enable research and clinical comparison, and adopting an easy-to-use graphical user interface for the computation of organ dimensions.

Aim

The study aimed at establishing standard measuring protocol in addition to baseline reference data using normal Magnetic Resonance Images of the brains and developing a user-friendly graphical user interface for the estimation of ventricular volume for clinical applications.

Methodology

A retrospective study design approach was adopted, and a convenient sampling technique was used to collect a total of 200 magnetic resonance images and 112 of that met the inclusion criteria were analysed at two imaging facilities in Ghana. Data samples were processed using MeVisLab (MVL) DICOM image analysis and processing software application tools for segmentation and measurements of the images. Minitab statistical tool was used for statistical modeling of ventricular volume models, and script writing (coding) was done using Python application programme and was also used to design and developed a GUI for the ventricular volume calculator.

Results

The overall mean age for the study is 54 years and ranged between 20-89yrs. The overall mean and S.D of the ventricular volume calculated in the study was 33.60 ± 12.07 cm3. The mean Total Ventricular volume (TVV) per each age group, that is, for 20–29 yrs, 30–39 yrs, 40–49 yrs, 50–59 yrs, 60–69 yrs, 70–79 yrs and 80–89 yrs were; (15.49 ± 2.09cm3), (23.47 ± 2.30cm3), (29.41 ± 2.93cm3), (32.14 ± 1.83cm3), (35.54 ± 1.48cm3), (47.54 ± 2.01cm3) and (51.60 ± 3.66cm3) respectively. Regression linear equations modeled per ventricle were as follows: for left lateral ventricle volume [LLVV (cm3) = 0.95 + 1.89L*W*T], for right lateral ventricle volume [RLVV (cm3) = 2.41 + 1.51L*W*T], for the third ventricle volume [3RDVV (cm3) = 0.81 + 0.77L*W*T] and for the fourth ventricle volume [4THVV (cm3) = 0.88 + 0.95L*W*T].

Conclusion

Optimized standard reference dataset of ventricular volumes and sizes of normal brains are crucial baseline determinants for early detection of cerebral diseases and mathematical modeling and GUI holds high prospects in the computation of these organ dimensions in medical imaging.
Repetitive and compulsive behavior after Early-Life-Pain in mice
Authors: Vogel Alexandra , Ueberbach Timo , Wilken-Schmitz Annett , Hahnefeld Lisa , Franck Luisa , Weyer Marc-Philipp , Jungenitz Tassilo , Schmid Tobias , Buchmann Giulia , Freudenberg Florian , Brandes Ralf P. , Gurke Robert , Schwarzacher Stephan W. , Geisslinger Gerd , Mittmann Thomas , Tegeder Irmgard
Published: February 2023

Pain in early life may affect cortical development and risk of chronic pain. We developed an optogenetic Cre/loxP mouse model of "early-life-pain" (ELP) using mice with transgenic expression of channelrhodopsin-2 (ChR2) under control of the Advillin (Avil) promoter, which drives expression of ChR2 in peripheral somatosensory neurons. Avil-ChR2 (Cre+) and ChR2-flfl control mice were exposed to blue light in a chamber once daily from P1-P5 together with their Cre-negative mother. ELP caused cortical hyperexcitability at P8-9 as assessed via multi-electrode array recordings that coincided with reduced expression of synaptic genes (RNAseq) including Grin2b, neurexins, piccolo and voltage gated calcium and sodium channels, suggesting activity-dependent synaptic pruning. Young adult (8-16 wks) Avil-ChR2 mice presented with nociceptive hypersensitivity upon heat or mechanical stimulation, which did not resolve up until one year of age. The persistent "pain" phenotype was reflected by capsaicin hypersensitivity in primary sensory neurons of aged mice (1 year) as assessed by calcium imaging. Adult Avil-ChR2 mice behaved like controls in maze tests of anxiety, social interaction and spatial memory but IntelliCage behavioral studies revealed repetitive nosepokes and corner visits and compulsive lickings. Compulsiveness at the behavioral level was associated with a reduction of sphingomyelin species in brain and plasma lipidomic studies pointing to alterations of sphingolipid metabolisms, which have been previously described in the context of addiction and psychiatric diseases. Hence, ELP may predispose to chronic pain and compulsive psychopathology.
The burden of Ischemic Heart Disease and the Epidemiologic Transition in the Eastern Mediterranean Region: 1990-2019
Authors: Sadeghi Masoumeh , Jamalian Marjan , Mehrabani-Zeinabad Kamran , Turk-Adawi Karam , Kopec Jacek , AlMahmeed Wael , Rahim Hanan Abdul F. , Farhan Hasan Ali , Anwar Wagida , Manla Yosef , Fadhil Ibtihal , Lui Michelle , Roohafza Hamidreza , Islam Sheikh Mohammed Shariful , Sulaiman Kadhim , Bazargani Nooshin , Saade George , Hassen Nejat , Alandejani Amani , Abdin Amr , Alhabib Khalid F , Bokhari Saira , Roth Gregory A , Johnson Catherine , Stark Benjamin , Sarrafzadegan Nizal , Mokdad Ali H.
Published: February 2023

Introduction

The purpose of this study is to investigate the trends of the burden of ischemic heart disease (IHD) in the Eastern Mediterranean Region (EMR) countries from 1990 to 2019.

Method

Prevalence, disability-adjusted life years (DALYs), death, DALYs attribution risk factors, healthcare access and quality index (HAQ), and universal health care (UHC) were extracted from the database of the Global Burden of Disease study (GBD) for the EMR countries. Data stratification is based on the social demographic index (SDI). Cardiac rehabilitation data was obtained from the International Council of Cardiovascular Prevention and Rehabilitation (ICCPR) and other information was e obtained by an advanced search of individualized countries’ data.

Result

IHD age-standardized prevalence increased from 4.96% to 5.31% in the EMR from 1990-2019 while it decreased at the global level. In the EMR, the trend of age-standardized IHD death and DALYs rates decreased by 11.39% and 15.36% between 1990 and 2019 respectively, however, both rates were higher than the global rates. The burden of IHD in males was higher than females.
The highest decrease of IHD age-standardized prevalence, death and DALYs rate in the EMR countries occurred in Bahrain (-3.72%, -64.95%and-69.08%, respectively). However, the most increase of prevalence happened in Oman with a change of 14.40% and for death and DALY rates was in Pakistan (29.62% and 31.93%, respectively) in the studied period.
The top three attributed risk factor to IHD DALYs in the EMR in 2019 were high systolic blood pressure, high low-density lipoprotein cholesterol, and particular matter pollution. The 29-year trend of an attributed risk factor to IHD DALYs in the EMR (1990-2019) showed that the two factors of high fasting plasma glucose (64.03%) and high BMI (23.39%) had an increasing trend, respectively.

Conclusion

Our results showed an increased trend of the prevalence of IHD in the EMR that requires well planned prevention and treatment strategies. Developing and implementing programs to address the risk factors through health promotion and education, preventive programs, and medical care should be a priority for countries in this region.
Eco-friendly one-step synthesis of highly functionalized-spirooxindole-pyranopyrazoles and their in-vitro anticancer studies
Authors: Asif Mohd , Aqil Farrukh , Almalki Amani salem , Alasmary Fatmah Ali , Khan Abdul Rahman , Nasibullah Malik
Published: February 2023

Herein, the one-step, multi-component reaction (MCR) of a series of spirooxindole-pyranopyrazole derivatives (5a-g), via a Knoevenagel condensation and Michael addition cascade, under mild and green reaction conditions, is reported. The newly synthesized derivatives were screened for in vitro anti-cancer activity against 60 human cancer cell lines at the National Cancer Institute (NCI), USA. We found that compounds 5c, 5d, and 5g showed good activity against the HOP-92 (lung cancer), UO-31 (renal cancer), KM-12, SW-620 (colon cancer), and HS578T (breast cancer) cell lines. Compound 5c showed 43.19% and 21.18% growth inhibition at 10 µM for HOP-92 and UO-31 cell lines, respectively, while compound 5g showed 82.02% growth inhibition for the KM12 cell line at the same concentration. Therefore, the compound 5g could be further derivatized as a futuristic lead molecule for colorectal cancer.
High-performance Supercapacitors Enabled by N/S Dual-doped Porous Carbon and DMO-regulated Electrolyte
Authors: Zhao jingyuan , Wang Meng , Jiang Chaojie , Liu Zhenyan , Lin Jiayu , Meng Xue , Zhang Pengfei , Deng Kuilin
Published: February 2023

The pristine carbon materials and traditional electrolytes can not fully meet the increasing practical demand for the high-performance of supercapacitors. Herein, a petal-like multicyclic polycondensate precursor (PCDP) was first prepared by Knoevenagel reaction and amine/aldehyde condensation between 3-aminorhodanine and p-phthalaldehyde. The subsequent activation of PCDP by KOH and final carbonization at different temperatures (600–900 ℃) was performed to get N/S-dual doped porous carbon (N/S-DDPCs) as electrode materials. For N/S-DDPC8 carbonized at 800 ℃, the highest specific surface area was measured as 2047 m2 g− 1, with a large number of interconnected microporous and mesoporous structures and the higher N and S contents of 3.57% and 2.31%, respectively. In addition, Zn(CF3SO3)2 aqueous electrolyte regulated by dimethyl oxalate (DMO) was fabricated in order to further enhance and stabilize the electrochemical performance for N/S-DDPCs. In contrast to the traditional Zn(CF3SO3)2 electrolyte, the energy density and power density of N/S-DDPC8 in DMO-regulated Zn(CF3SO3)2 electrolyte was significantly increased to 36.4 Wh kg− 1 from 11.7 Wh kg− 1 and to 642 W kg− 1 from 250 W kg− 1 at a current density of 0.5 A g− 1, respectively. Most excitedly, N/S-DDPC8-DMO-D can maintain 100% specific capacitance even after 10000 cycles, showing the superhigh electrochemical stability. In brief, N/S-dual doped porous N/S-DDPCs and DMO-regulated electrolyte prepared in this study provides a useful reference for the synergistically enhancing the electrochemical performance for the supercapacitors.
Model test study of oil and gas pipeline crossing landslide
Authors: Wang Yuan Dong
Published: February 2023

As an ultra-long linear project, oil and gas pipelines are vulnerable to landslide disasters, which poses a serious threat to the normal operation of pipelines and the safety of national property. Taking shallow soil and lateral landslide, which are the most common in pipeline landslide accidents, as the main research objects, large-scale model tests were carried out. Different slopes and different landslide displacement conditions were controlled and changed by model box loading device, and the stress response rule and deformation failure characteristics of pipeline under the action of lateral landslide were studied. The research results show that the pipeline buckling occurs locally in the midspan, and the whole pipeline is in the form of beam symmetric bending failure. When the pipeline is in the elastic and elastic-plastic stage, the test value of the pipeline axial strain is basically consistent with the results of numerical simulation (PSI model and solid element model), and the test value of the pipeline buckling failure is significantly greater than the numerical simulation results. The research results have important guiding significance for the laying and prevention of oil and gas pipelines in mountainous areas.
The efficacy and safety of CT-guided 125I seed implantation by coplanar template as a salvage therapy for vertebral metastases after failure of external beam radiation therapy: a retrospective study
Authors: Li Peishun , Man Qirong , Bai Yunling , Xing Chao , Yuan Qianqian , Yang Wanying , Ren Yanchen , Zhang Kaixian
Published: February 2023

Purpose
To evaluate the efficacy and safety of computed tomography (CT)-guided 125I seed implantation by coplanar template for vertebral metastases after failure of external beam radiation therapy. We also want to compare the dosimetry of 3D printed coplanar template-assisted interstitial 125I brachytherapy preoperative and postoperative, and to explore the accuracy of this technology.
Material and methods
We retrospectively collected and analyzedthe results of 56 patients with vertebral metastases after failure of external beam radiation therapy, who underwent interstitial 125I brachytherapy as a salvage treatment with a CT-guided coplanar template-assisted technique from January 2015 to January 2017.
Results
The NRS score for worst pain was 6.1 ± 1.1 before 125I seed implantation. The mean posto-perative NRS score decreased significantly at T4w (3.5 ± 0.9, p < 0.01), T8w (2.1 ± 0.9, p < 0.01), T12w (1.5 ± 0.7, p < 0.01) and T6m (1.2 ± 0.6, p < 0.01) respectively. There was no significant difference in scores among T0, T24h (P = 0.10) and T1w (P = 0.09). The local control rates after 3, 6, 9 and 12 months were 100% (58/58), 92.5% (49/53), 90.2% (46/51), and 85.1% (40/47), respectively. By performing paired t-test analysis, there were no significant differences in D90, D100, V90, V100, V150, V200, GTV volume, CI, EI and HI between preoperative and postoperative(p༞0.05). Postoperative D90 was an independent influencing factor of local control time (HR: 1.047, 95% CI: 0.998–1.098, p = 0.043). The optimal Cut-off value of postoperative D90 was 130 Gy.
Conclusions
Interstitial 125I seed implantation can be used as a salvage treatment forpatients with vertebral metastases after failure of external beam radiation therapy. With the auxiliary function of 3D printed coplanar template, the main dosimetry parameters verified after the operation can meet the requirements of the preoperative plan with good treatment accuracy.