bluuebunny/crossref_metadata_2025 huggingface dataset:
High Density Display of an Anti-Angiogenic Peptide on Micelle Surfaces Enhances Their Inhibition of αvβ3 Integrin-Mediated Neovascularization In Vitro
Authors: Nagaraj Rajini , Stack Trevor , Yi Sijia , Mathew Benjamin , Shull Kenneth R , Scott Evan A , Mathew Mathew T , Bijukumar Divya Rani
Published: March 2020

Diabetic retinopathy (DR), Retinopathy of Pre-maturity (ROP), and Age-related Macular Degeneration (AMD) are multifactorial manifestations associated with abnormal growth of blood vessels in the retina. These three diseases account for 5% of the total blindness and vision impairment in the US alone. The current treatment options involve heavily invasive techniques such as frequent intravitreal administration of anti-VEGF (vascular endothelial growth factor) antibodies, which pose serious risks of endophthalmitis, retinal detachment and a multitude of adverse effects stemming from the diverse physiological processes that involve VEGF. To overcome these limitations, this current study utilizes a micellar delivery vehicle (MC) decorated with an anti-angiogenic peptide (aANGP) that inhibits αvβ3 mediated neovascularization using primary endothelial cells (HUVEC). Stable incorporation of the peptide into the micelles (aANGP-MCs) for high valency surface display was achieved with a lipidated peptide construct. After 24 h of treatment, aANGP-MCs showed significantly higher inhibition of proliferation and migration compared to free from aANGP peptide. A tube formation assay clearly demonstrated a dose-dependent angiogenic inhibitory effect of aANGP-MCs with a maximum inhibition at 4 μg/mL, a 1000-fold lower concentration than that required for free from aANGP to display a biological effect. These results demonstrate valency-dependent enhancement in the therapeutic efficacy of a bioactive peptide following conjugation to nanoparticle surfaces and present a possible treatment alternative to anti-VEGF antibody therapy with decreased side effects and more versatile options for controlled delivery.
The Effect of Whey Protein Supplementation on Myofibrillar Protein Synthesis and Performance Recovery in Resistance-Trained Men
Authors: Davies Robert W. , Bass Joseph J. , Carson Brian P. , Norton Catherine , Kozior Marta , Wilkinson Daniel J. , Brook Matthew S. , Atherton Philip J. , Smith Ken , Jakeman Philip M.
Published: March 2020

Background: The aim of this study was to investigate the effect of whey protein supplementation on myofibrillar protein synthesis (myoPS) and muscle recovery over a 7-d period of intensified resistance training (RT). Methods: In a double-blind randomised parallel group design, 16 resistance-trained men aged 18 to 35 years completed a 7-d RT protocol, consisting of three lower-body RT sessions on non-consecutive days. Participants consumed a controlled diet (146 kJ·kg−1·d−1, 1.7 g·kg−1·d−1 protein) with either a whey protein supplement or an isonitrogenous control (0.33 g·kg−1·d−1 protein). To measure myoPS, 400 ml of deuterium oxide (D2O) (70 atom %) was ingested the day prior to starting the study and m. vastus lateralis biopsies were taken before and after RT-intervention. Myofibrillar fractional synthetic rate (myoFSR) was calculated via deuterium labelling of myofibrillar-bound alanine, measured by gas chromatography-pyrolysis-isotope ratio mass spectrometry (GC-Pyr-IRMS). Muscle recovery parameters (i.e., countermovement jump height, isometric-squat force, muscle soreness and serum creatine kinase) were assessed daily. Results: MyoFSR PRE was 1.6 (0.2) %∙d−1 (mean (SD)). Whey protein supplementation had no effect on myoFSR (p = 0.771) or any recovery parameter (p = 0.390–0.989). Conclusions: Over an intense 7-d RT protocol, 0.33 g·kg−1·d−1 of supplemental whey protein does not enhance day-to-day measures of myoPS or postexercise recovery in resistance-trained men.
Incorporating Milk Protein Isolate into an Energy-Restricted Western-Style Eating Pattern Augments Improvements in Blood Pressure and Triglycerides, but Not Body Composition Changes in Adults Classified as Overweight or Obese: A Randomized Controlled Trial
Authors: Hudson Joshua L. , Zhou Jing , Kim Jung Eun , Campbell Wayne W.
Published: March 2020

Unhealthy Western-style eating patterns (WSEP) predominate, adversely affecting health. Resistance to improving dietary patterns prompts interest to incorporate a potentially health-promoting ingredient into typical WSEP foods and beverages. We assessed the effect of incorporating isocalorically matched carbohydrates versus milk protein isolate (MPI) into a WSEP on weight loss-induced changes in cardiometabolic health and body composition. In a randomized, double-blind, parallel-design study, 44 participants (age 52 ± 1 years, body mass index (BMI) 31.4 ± 0.5 kg/m2, mean ± standard error) consumed a weight maintenance WSEP (0.8 g total protein/kg/day) for 3 weeks (baseline). After, participants consumed an energy-restricted (750 kcal/day below estimated requirement) WSEP for 16 weeks, randomly assigned to contain either an additional 0.7 g carbohydrate/kg/d (CON: n = 23, 0.8 g total protein/kg/day) or 0.7 g protein/kg/d from MPI (MPI: n = 21, 1.5 g total protein/kg/day) incorporated into foods and beverages. Compared to CON, the MPI favored reductions in average 24 h and sleeping systolic and diastolic blood pressures (BP), waking hours systolic BP, and fasting plasma triglyceride concentrations. Reductions in fasting plasma insulin, glucose, total cholesterol, and low-density lipoprotein cholesterol concentrations were not different between groups. Among all participants, whole body mass, lean mass, fat mass, and thigh muscle area, each decreased over time. For adults finding it difficult to deviate from a WSEP, replacing a portion of their carbohydrate with foods and beverages containing MPI may be an effective dietary strategy to reduce BP after weight loss.
Genomic Features of Cladobotryum dendroides, Which Causes Cobweb Disease in Edible Mushrooms, and Identification of Genes Related to Pathogenicity and Mycoparasitism
Authors: Xu Rong , Liu Xiaochen , Peng Bing , Liu Peibin , Li Zhuang , Dai Yueting , Xiao Shijun
Published: March 2020

Cladobotryum dendroides, which causes cobweb disease in edible mushrooms, is one of the major fungal pathogens. Our previous studies focused on the genetic and morphological characterization of this fungus, as well as its pathogenicity and the identification of appropriate fungicides. However, little is known about the genome characters, pathogenic genes, and molecular pathogenic mechanisms of C. dendroides. Herein, we reported a high-quality de novo genomic sequence of C. dendroides and compared it with closely-related fungi. The assembled C. dendroides genome was 36.69 Mb, consisting of eight contigs, with an N50 of 4.76 Mb. This genome was similar in size to that of C. protrusum, and shared highly conserved syntenic blocks and a few inversions with C. protrusum. Phylogenetic analysis revealed that, within the Hypocreaceae, Cladobotryum was closer to Mycogone than to Trichoderma, which is consistent with phenotypic evidence. A significant number of the predicted expanded gene families were strongly associated with pathogenicity, virulence, and adaptation. Our findings will be instrumental for the understanding of fungi–fungi interactions, and for exploring efficient management strategies to control cobweb disease.
Response of Human Neutrophil Granulocytes to the Hyphae of the Emerging Fungal Pathogen Curvularia lunata
Authors: Tóth Eszter Judit , Varga Mónika , Takó Miklós , Homa Mónika , Jáger Olivér , Hermesz Edit , Orvos Hajnalka , Nagy Gábor , Vágvölgyi Csaba , Papp Tamás
Published: March 2020

Curvularia lunata is an ascomycete filamentous fungus causing local and invasive phaeohyphomycoses in both immunocompromised and immunocompetent patients. Neutrophils are crucial participants of the first line host defense against fungal infections. They migrate to the infected site and eliminate the infectious agents by various mechanisms including phagocytoses, oxidative damage, or formation of neutrophil extracellular trap (NET). Neutropenia may be a risk factor for phaeohyphomycoses, and restoration of the neutrophil function can improve the outcome of the infection. In the present study, interaction of primary human neutrophil granulocytes with the hyphae C. lunata was examined and compared to that with the well characterized filamentous fungal pathogen Aspergillus fumigatus. Neutrophils could recognize the serum opsonized hyphae of C. lunata and attach to them. Myeloperoxidase release was also activated by a soluble factor present in the culture supernatant of the fungus. Induction of the oxidative burst was found to depend on serum opsonization of the hyphae. Although extracellular hydrogen peroxide production was induced, the fungus efficiently blocked the oxidative burst by acidifying the reaction environment. This blockage also affected the NET forming ability of the neutrophils.
Enhancing Clinical Pharmacy Specialist Involvement in Transitions of Care Focusing on Ambulatory Care Sensitive Conditions within a Veterans Affairs Healthcare System
Authors: Fisher Morgan , Cardoza Amber , Gordon Autumn , Howard Molly , Neighbors Lynsey , Ragan Addison
Published: March 2020

The purpose of this quality improvement project was to evaluate the impact of clinical pharmacy specialist (CPS) involvement in the post-discharge period on 30-day readmission rates within a Veterans Affairs Healthcare System. Patients eligible for inclusion were discharged from a Veterans Affairs (VA) acute care facility with a principle or secondary diagnosis of heart failure (HF), chronic obstructive pulmonary disease (COPD), or both HF and COPD from 15 October 2018 through 14 January 2019. CPSs functioning as a mid-level provider with a scope of practice conducted telephone and in-clinic medication management appointments within 7 and 21 days post-discharge for qualifying patients discharged with a principle or secondary diagnosis of HF or COPD. CPS appointments focused on medication reconciliation, ensuring continuity of care, disease state counseling, and medication management. By enhancing the role of the CPS in the post-discharge period, there was an observed decrease in 30-day COPD index (p = 0.35), HF index (p = 0.23), and all-cause (p = 0.62) readmission rates from pre- to post-intervention. The results of this intervention show that CPS intervention in the post-discharge period may reduce index and all-cause readmission rates for patients discharged with a principle or secondary discharge diagnosis of COPD or HF.
Differential Localization of Structural and Non-Structural Proteins during the Bluetongue Virus Replication Cycle
Authors: Mohl Bjorn-Patrick , Kerviel Adeline , Labadie Thomas , Matsuo Eiko , Roy Polly
Published: March 2020

Members of the Reoviridae family assemble virus factories within the cytoplasm of infected cells to replicate and assemble virus particles. Bluetongue virus (BTV) forms virus inclusion bodies (VIBs) that are aggregates of viral RNA, certain viral proteins, and host factors, and have been shown to be sites of the initial assembly of transcriptionally active virus-like particles. This study sought to characterize the formation, composition, and ultrastructure of VIBs, particularly in relation to virus replication. In this study we have utilized various microscopic techniques, including structured illumination microscopy, and virological assays to show for the first time that the outer capsid protein VP5, which is essential for virus maturation, is also associated with VIBs. The addition of VP5 to assembled virus cores exiting VIBs is required to arrest transcriptionally active core particles, facilitating virus maturation. Furthermore, we observed a time-dependent association of the glycosylated non-structural protein 3 (NS3) with VIBs, and report on the importance of the two polybasic motifs within NS3 that facilitate virus trafficking and egress from infected cells at the plasma membrane. Thus, the presence of VP5 and the dynamic nature of NS3 association with VIBs that we report here provide novel insight into these previously less well-characterized processes.
Human Papillomavirus (HPV69/HPV73) Coinfection associated with Simultaneous Squamous Cell Carcinoma of the Anus and Presumed Lung Metastasis
Authors: Shea Stephanie , Muñoz Marina , Ward Stephen C. , Beasley Mary B. , Gitman Melissa R , Nowak Michael D , Houldsworth Jane , Sordillo Emilia Mia , Ramirez Juan David , Paniz Mondolfi Alberto E.
Published: March 2020

Background: Human papillomaviruses (HPVs) have been linked to a variety of human cancers. As the landscape of HPV-related neoplasia continues to expand, uncommon and rare HPV genotypes have also started to emerge. Host-virus interplay is recognized as a key driver in HPV carcinogenesis, with host immune status, virus genetic variants and coinfection highly influencing the dynamics of malignant transformation. Immunosuppression and tissue tropism are also known to influence HPV pathogenesis. Methods: Herein, we present a case of a patient who, in the setting of HIV positivity, developed anal squamous cell carcinoma associated with HPV69 and later developed squamous cell carcinoma in the lungs, clinically presumed to be metastatic disease, associated with HPV73. Consensus PCR screening for HPV was performed by real-time PCR amplification of the L1 gene region, amplification of the E6 regions with High-Resolution Melting Curve Analysis followed by Sanger sequencing confirmation and phylogenetic analysis. Results: Sanger sequencing of the consensus PCR amplification product determined that the anal tissue sample was positive for HPV 69, and the lung tissue sample was positive for HPV 73. Conclusions: This case underscores the importance of recognizing the emerging role of these rare “possibly carcinogenic” HPV types in human carcinogenesis.
Protective Effect of Seasonal Influenza Vaccination in Elderly Individuals with Disability in Taiwan: A Propensity Score–Matched, Nationwide, Population-Based Cohort Study
Authors: Chang Yu-Chia , Yu-Tung Huang , Chen Long-Sheng , Tung Ho-Jui , Huang Kuang-Hua , Ernawaty Ernawaty , Wu Szu-Yuan
Published: March 2020

This is the first and largest population-based cohort study to demonstrate that influenza vaccination reduced all-cause mortality and influenza-related hospitalization in elderly individuals with a disability. Purpose: To estimate the protective effect of influenza vaccination in elderly individuals with a disability by conducting a propensity score-matched (PSM), nationwide, population-based cohort study. Methods: Data from Taiwan’s National Health Insurance Research Database were used in this study. Generalized estimating equations (GEEs) were used to compare outcomes between the vaccinated and unvaccinated cohorts. The GEE logit was used to estimate the relative risks of death and hospitalization after influenza vaccination. Adjusted odds ratios (aORs) were used to estimate relative risk. Results: The matching process yielded a final cohort of 272 896 elderly individuals with a disability (136 448 individuals in each cohort). In multivariate GEE analyses, aOR (vaccinated vs. unvaccinated) and 95% confidence interval (CI) of death were 0.70 (0.68–0.72). The aORs (95% CIs) of hospitalization for influenza and pneumonia, respiratory diseases, respiratory failure, heart disease, hemorrhagic stroke, and ischemic stroke were 0.98 (0.95–1.01), 0.96 (0.94–0.99), 0.85 (0.82–0.89), 0.96 (0.93–0.99), 0.85 (0.75–0.97), and 0.89 (0.84–0.95), respectively. The length of stay and medical expenditure exhibited greater reduction in vaccinated elderly individuals with a severe and very severe disability than in unvaccinated elderly individuals. Conclusions: Influenza vaccination reduced all-cause mortality, influenza-related hospitalization, length of stay, and medical expenditure in elderly individuals with a disability. The decrease in the length of stay and medical expenditure because of influenza vaccination was proportional to the severity of disability.
Contributions of critical thinking as a form of participation and political deliberation
Authors: Arbeláez-Campillo Diego Felipe , Tatsiy Vasyl Ya. , Rojas-Bahamón Magda Julissa , Danilyan Oleg G.
Published: March 2020

Critical thinking is an attribute of consciousness that can be manifested in all human activities where it is required, as a condition of possibility, in the use of critical reason and deliberation. Consequently, it is in the domains of politics that critical thinking is used more frequently, to discuss the scope and concrete significance of the discourses and practices that, from the exercise of public powers, are deployed on intelligent citizenship and with the minimum necessary of information for peer deliberation. The objective of this article is to deconstruct the most common contributions of critical thinking as a form of participation and political deliberation. Methodologically it is a research of documentary design developed in the coordinates of the philosophical essay, next to the Latin American philosopher and the revision of the most popular political theory. Among the main findings, the idea that critical thinking is not the exclusive patrimony of certain self-defined political and ideological tendencies as progressive in the region stands out. It is concluded that, this way of thinking is uncomfortable per se for all the paradigms that serve as the basis for the status quo, in politics and society.
Burnout Determinants and Consequences Among University Lecturers
Authors: Shawkat Mohammed Sarkhel , Suleyman Celik , Taylan Budur
Published: March 2020

The aim of the study is to investigate the Lecturers’ burnout behaviors and consequences in public and private higher education institutions in the Kurdistan region of Iraq. Because of the economic and political problems in the region public sector employees suffered from irregular salary payments, even at about 15 months without any payment between 2014-2016. Based on the current paper aimed to search the consequences of these problems on the Lecturers. To do this a survey questionnaire organized and distributed between the two universities. In total, 170 questionnaires were them appropriate to further evaluation. As conclusion, it is noted that depersonalization is the next level of emotional exhaustion. Further, it can be said that depersonalization is a deeper psychological problem after emotional exhaustion.
Regulatory Provision of the Passenger's Rights in the System of Warranties of their Compliance and Realization
Authors: Samoylenko Georgiy , Shchypanova Olga , Bychkivskyi Oleksii , Luts Dmytro , Nikolaienko Ihor
Published: March 2020

The article deals with topical issues of securing the rights of the passenger. As violations of this kind of rights are frequent and the means of protection of their rights, except for air transport, are virtually absent under the transport law of Ukraine, except for the possibility of compensation for non-pecuniary damage, the presence and amount of which is determined by court procedure, there is an urgent need to determine and regulate this civil rights, how it is under EU law on new civilizational approaches; securing regulatory safeguards to enforce and exercise their rights. The authors conclude that according to the legislation of Ukraine there are practically no guarantees for the exercise of the rights of the passenger, which is unacceptable at this stage of civilization development. As the mechanism for securing this kind of civil rights under EU law, which is based on the concept of creating a competitive environment, regulating and securing the rights of passengers, establishing negative consequences for the carrier in the event of a violation of the passenger's rights in the form of compensation amounts, despite the fact that he is debatable and imperfect, however, it can be implemented into the national legislation of Ukraine. In addition to the right to require the carrier to deliver it to its destination, the basic rights of the passenger must be legally enshrined and guaranteed: security, human rights, mobility, non-discrimination, assistance in transportation, accessibility, full and reliable information, on the use of remedies, on compensation in case of violation of rights, etc.
A STUDY ON VIRAL ETIOLOGIES OF LOWER RESPIRATORY INFECTIONS IN CHILDREN HOSPITALIZED IN HUE CENTRAL HOSPITAL FROM MARCH-2010 TO APRIL 2011
Authors: Le Van An , Huynh Thi Hai Duong , Nguyen Chien Thang , Nguyen Hoang Bach , Phan Thi Bich Chi , Le Thi Ngoc Viet , Dinh Quang Tuan , Cappuccinelli Piero
Published: March 2020

Introduction: Lower respiratory infections caused by respiratory viruses have played an important role in morbility and mortality in young children. Identification of viral etiologies has not been done in poor countries due to the lack of laboratory facilities for viral diagnosis. This study was to determine viral etiologies in children hospitalized with lower respiratory infections.
Patients and methods: Nasal pharyngeal swabs or throat swabs were collected from 216 children hospitalized clinically with lower respiratory infections and processed for viral identification by RT-PCR and PCR.
Results: Viral respiratory infections were detected in 91 children (42%) with 107 respiratory viruses, majority of infected children were younger than 5 years of age. among them 76 children (84%) have single infection and 15 children (16%) have co-infections of 2 or 3 viruses. The most common respiratory virus was influenza A virus with 41 cases (45%), followed by RSV with 38 cases (42%), adenovirus in 11 cases (12%), influenza B virus in 7 (8%) and parainfluenza virus type 1 and 3 in 5 cases (5%) each. RSV infections were found in several months, whereas, influenza virus infections were found in high numbers in rainy and cold months from October of 2010 to February of following year, influenza A(H1N1)pdm09 was the predominant subtype of influenza A virus.
Conclusion: Respiratory viruses were found with the high rate in children hospitalized with lower respiratory infections; the common viruses detected were influenza A(H1N1) pdm09 virus and RSV. Key words: influenza, RSV, lower respiratory infections
STUDY OF PRENATAL SCREENING AND DIAGNOSIS FOR DOWN, EDWARD AND PATAU SYNDROME IN THE CENTRAL OF VIETNAM
Authors: Doan Huu Nhat Binh , Le Tuan Linh , Nguyen Viet Nhan , Ha Thi Minh Thi , Doan Thi Duyen Anh , Le Phan Tuong Quynh
Published: March 2020

Background: This study aimed to evaluate the results of prenatal screening and diagnosis for Down, Edward and Patau syndrome in the central of Vietnam.
Materials and method: First trimester screening using combined serum marker test (free β-HCG, PAPP-A) including nuchal translucency by the FMF software. The high risk pregnancies was tested by QF-PCR diagnosis using amniotic fluid.
Results: Screening for 1516 pregnancies, 145 pregnancies at high risk for Down, Edward and Patau syndrome. However, there was only 78 of them agreed to participate in diagnostic amniocentesis. Found 7 cases of abnormal number of chromosomes.
Conclusion: The rate of high-risk pregnancies was 9.6%. Percentage of pregnancy with high-risk diagnostic agreement was 53.8%. The rate of abnormal number of chromosomes was 9.0%, in which 85.7% of T21, 14.3% of T18, did not find any cases of T13 detected by QF-PCR technique.
BMI AND CARDIAC PHYSIOLOGICAL PARAMETERS OF SECONDARY SCHOOL PUPILS OF SOME ETHNIC GROUPS IN KONTUM
Authors: Vo Van Toan , Le Van Trong
Published: March 2020

Objectives: Research the index morphology and physiology of the pupil in the ages of 11 to 14.
Subjects and Methods: Subjects the pupil in the ages from 11 to 14 years including Kinh, Dẻ, Xê Đăng, Rơ Ngao and Mơ Nâm. Researching indicators include: BMI, heart rate, arterial blood pressure. Methods: Routine methods were standardized to examine the morphological and physiological indicators.
Results:
(i) Research results show that in the period from 11 to 14 years the index morphology and physiology of the pupil is still not stable.
(ii) Height and weight increases with age class. The change in height and weight make changes in BMI.
(iii) Based on BMI can see that most pupils are not provided adequate nutrition.
Conclusion: In the period 11-14 years, operation of the circulatory system is stabilized gradually, heart frequency decreases but blood pressure increases with age
EFFECTS OF INONIZING RADIATION CAUSED HEAT STRESS ON THE HUMAN BODY FOR STANDARD ISO 7243
Authors: Le Van Trong , Nguyen Thi Tuyet Mai , Nguyen Thi Xuan Duyen , Nguyen Ba Luan , Pham Tuyen , Phan Vu Cao Quang , Le Thi Cam Tu
Published: March 2020

Objectives: Presents heat stress Standard ISO 7243, which is based upon the wet bulb globe temperature index (WBGT), and considers its suitability for use worldwide.
Materials and Methods: The WBGT index are considered and how it is used in ISO 7243 and across the world as a simple index for monitoring and assessing hot environments.
Results: Management systems, involving risk assessments, that take account of context and culture, are required to ensure successful use of the standard and global applicability. For use outdoors, a WBGT equation that includes solar absorptivity is recommended. A ‘clothed WBGT’ is proposed to account for the effects of clothing.
Conclusion: ISO 7243 is a simple tool to assess the heat stress and may be applicated worldwide.
EVALUATION OF THE EFFECTIVENESS OF NECK SHOULDER PAIN TREAMENT BY ACUPUNCTURE, MASSAGE AND TRADITIONAL MEDICINE REMEDY
Authors: Nguyen Thi Tan
Published: March 2020

Objectives: To assess the effectiveness neck shoulder pain treatment by acupuncture, massage and traditional medicine remedy.
Materials and Methods: 42 patients included in the inpatient and outpatient at the Department of Traditional Medicine, Hue Central Hospital and Traditional Medicine Hospital of Thua Thien Hue, was diagnosed as neck shoulder pain. Patients were treated with acupuncture, massage and medicine, according to the research methodology, assessing the results before and after treatment.
Results: The age accounted for the highest proportion of 31-45 (42.49%), the second is between the ages of 46-60 (26.18%) and> 60 (26.18%). Incidence in the city (66.67%) than rural (33.33%) (p <0:05). Patients presented with neck shoulder pain (100%), together with the head pain, pain in the shoulder, arm numbness, movement restrictions tilted head bowed.
Conclusion: good variety and accounted for 71.42% of which are quite good account of 14.28%, only 2.38% is poor. Results of good, high aged 31-45 (35.72%) and in patients with a course of treatment (66.66%).

Key words: neck shoulder pain, acupuncture, massage, traditional medicine remedy.
TOTAL POLYPHENOL CONTENT, FREE RADICAL SCAVENGING, ALPHA-GLUCOSIDASE INHIBITION CAPACITY, THE EFFICACY IN CONTROLLING BLOOD GLUCOSE OF DIABETIC RATS OF THE MIXTURE VOS EXTRACTED FROM THE LEAVES OF CLEISTOCALYX OPERCULATUS, PSIDIUM GUAJAVA AND NELUMBO NUCIFERA
Authors: Truong Tuyet Mai , Nguyen Thi Lam , Pham Lan Anh , Truong Hoang Kien
Published: March 2020

Objective: Plant polyphenols have antioxidant capacity and alpha-glucosidase inhibition to supporting for prevention and treatment of diabetes.
Materials and Method: Present study was conducted to determine the content of total polyphenols, free radical scavenging and alpha-glucosidase inhibition of the VOS mixture that extracted from leaves (Voi leaves - Cleistocalyx operculatus (V), Oi leaves - Psidium guajava (O), Sen leaves - Nelumbo nucifera (S)).
Results: The efficacy of blood glucose controlling in diabetic mice was investigated. After 8 weeks of administration with 200 mg VOS/kg body weight and 400 mg VOS/kg body weight, VOS diabetic mice had significantly reduced blood glucose level as compared to control diabetic mice. VOS diabetic mice with 400 mg dosage are lower in blood glucose levels than that of the diabetic mice with 200 mg. Also, the significant reducing in HbA1c was observed in VOS diabetic mice as compared with control diabetic mice.
Conclusion: VOS-product extracted from Cleistocalyx operculatus leaves, guava leaves, lotus leaves might be considered as a safe product and to be a potential product in the supporting of prevention and treatment of diabetes.
TO RESEARCH MORPHOLOGIC FEATURES, SIGNAL CHARACTERISTICS ON SONOGRAPHY AND DYNAMIC COMPUTED TOMOGRAPHY OF HEPATIC HEMANGIOMAS
Authors: Huynh Vi Thang , Le Trong Khoan , Vo Trong Hao
Published: March 2020

Objectives: To assess morphologic features, signal characteristics on sonography and dynamic computed tomography of hepatic hemangiomas. To compare the agreement degree of diagnosis of hepatic hemangiomas between sonography and computed tomography. Material and methods: We researched the sonography and computed tomography findings in 50 patients including 82 lesions hepatic hemangiomas at Hue university hospital and Hue central hospital from march 2012 to june 2013, 21 men and 29 women, mean age 51.7 ± 13.9 (range 30 – 89). Results: Mean mass diameter was 3.7 ± 1.9 cm. Sonography revealed hyperechonic pattern in 97.6% and hypoechonic pattern in 2.4%. On nonenhanced computed tomography, almost tumors (70.8%) showed hypodense, 26.8% had cleftlike areas of lower density than the main mass and 2.4% showed hyperdense lesions in a hypodense fatty liver. Almost tumors were periperally hyperdense on early contrast - enhanced computed tomography, progressive centripetal enhancement and in the delayed phase 85.4% displayed isodense and 14.6% displayed hyperdense fill-in. Conclusions: Triphasic helical computed tomography has additional values for sonography in diagnosis of hepatic hemangioma with typical characteristics: hypodense lesion on nonenhanced computed tomography, periperally hyperdense on early contrast - enhanced computed tomography, progressive centripetal enhancement and complete isodense fill-in of the lesion in the delayed phase. For tiny lesion smaller than 15mm (especially smaller than 10 mm), computed tomography plays a less important role.

Key words: Hepatic hemangiomas, signal characteristics, sonography, computed tomography, research.
ECHOCARDIOGRPAHY STUDY ON SYSTOLIC FUNCTION OF RIGHT VENTRICLE IN NORMAL ADULTS
Authors: Nguyen Anh Vu
Published: March 2020

Purpose: The ASE and ESC have recently published (2010) a guideline to assess the function of the right ventricle. The aim of this study was to get some Echo-Doppler parameters of the right ventricular systolic function in healthy adults. Method: We assessed 106 healthy adults (age 18-59). All were normal on clinic examination, ECG, X ray, and echocardiography. Results: Fractional area change 49.76 ± 7.328 %; Tricuspid annular plane systolic excursion (TAPSE) 22.5 ± 2.597mm; TDI velocity at the tricuspide annulus (S) 13.8 ± 2.138 cm/s; Tissue Doppler MPI (Tei index) 0.47 ± 0.049.A moderate correlation between S velocity and TAPSE (r = 0.38 p<0.01); Tei index and TAPSE (r = - 0.31, p < 0.01); ICT, IRT and age (r=0.29 p<0.01). Conclusion: All the received parameters are in the normal range of the guideline of ASE and ESC.

Key words: right ventricular function, TAPSE.
EVALUATION OF THE METHOSD FOR DETECTION METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS.
Authors: Nguyen Thi Kim Chi , Tran Dinh Binh , Nguyen Thi Nam Lien , Mai Van Tuan , Sylvain Godreuil
Published: March 2020

Objective: To evaluate the infections that caused by Methicillin-resistant Staphylococcus aureus and the value of the tests to detect Methicillin-resistant Staphylococcus aureus. Subjects and Methods: Used routine techniques to culture and isolate S.aureus, test the antibiotic sensitivity by Kirby-Bauerr, determination the Methicillin-resistant Staphylococcus aureus by Oxacillin and cefoxitin disc and PCR in identified the mecA gene Staphylococcus aureus. Results: The rate of Staphylococcus aureus isolated is highest which isolated from pus specimens (55.06%). In 267 strains of Staphylococcus aureus isolated in the Department of Microbiology, Hue Central Hospital the Methicillin resistance Staphylococcus aureus was 61.42%. The level of antibiotic resistant strains of Methicillin-resistant Staphylococcus aureus is higher than that in Methicillin-sensitive strains. Conclusion: Cefoxitin 30 microg disk diffusion method to detect Methicillin resistance is effective for determinate Methicillin-resistant Staphylococcus aureus (sensitivity and specificity are all 100.00%).

Key words: Staphylococcus aureus Methicillin-resistant.
Perth scoring system for assessment of the cleft lip
Authors: Monshizadeh Linda , Vijayasekaran Vijith
Published: March 2020

Background: Currently, there is no standardised assessment tool to assess facial aesthetics in cleft lip and palate surgery. Inter-centre comparison is hampered by the use of different aesthetic indices with low intra- and inter-rater reliability.
Aim: The Perth scoring system is a new assessment tool for unilateral cleft lip which scores four key components of the cleft lip/nose repair: lip length, white roll, alar insertion point and vermillion. The aim of this study was to validate the Perth scoring system as a reliable and useful new assessment tool and to demonstrate the use of the scoring system to measure improvements after cleft lip revision.
Method: Nineteen patients who underwent cleft lip revision by the senior author were selected. Pre- and postoperative photos were presented to a panel of raters to score. Scores were analysed to determine the intra-and inter-rater reliability and to compare outcomes.
Results: Almost all patients (15/16) had improvement in scores (range 1.09–5.59) after cleft lip revision. Intra raters’ agreement scores from lowest to highest were: lip length (0.65), white roll (0.7), alar insertion point (0.78) and vermillion (0.78). The total intra-class correlation coefficient was 0.96 (0.94–0.98, 95% CI, P<0.000).
Conclusion: This new scoring system is a valid and useful tool for assessment of the unilateral cleft lip. The high rate of intra- and inter-rater reliability allow it to serve as a useful tool to compare surgical outcomes both within and between centres. Further field testing with a larger cohort of patients is required.
Conservative treatment of subcapital phalangeal fracture malunions
Authors: McCombe David , Sandvall Brinkley , Coombs Christopher
Published: March 2020

Displaced subcapital phalangeal fractures of the middle or proximal phalanges occur primarily in children. The degree and direction of displacement, patient age and time since injury influence treatment decisions and patient outcomes. Delayed presentation with malunion and reduced joint motion is common. This paper presents a case series of displaced subcapital phalangeal fracture early malunions managed conservatively. Near complete remodelling of dorsal angular deformity was seen in all patients. Conservative management of phalangeal subcapital fracture malunions is a viable alternative to the complex procedure of corrective osteotomy.
Triquetral fractures—a retrospective, multi-centre study of management and outcomes
Authors: Hopkins Alyse , Bowman Sebastian RA , Preketes Angelo P , Dowd Michael B
Published: March 2020

Introduction: This study examines triquetral fracture data from six hospital centres between 2009 and 2018. The study focuses on elements of triquetral fracture management within these six centres, outlining common fracture patterns, the short-term and long-term outcomes and the common mechanisms of injury. To the authors’ knowledge, this is the largest cohort of triquetral fractures studied to date and outlines investigation recommendations for improved identification of these fractures.
Methods: Data was obtained by reviewing the charts of patients presenting to emergency departments within the Nepean and Blue Mountains local health district of New South Wales, Australia. (Nepean Hospital ethics approval no: NBM18/805)
Results: Triquetral fractures can be hard to identify with radiography and can be commonly mistaken as lunate fractures.12 Our results indicate that 18.9 per cent of patients required CT imaging to correctly diagnose triquetral fracture.
Conclusion: Where there are ongoing symptoms and a high clinical suspicion of a triquetral fracture, CT may be indicated and, in future practice, may be justified as a first line imaging modality. This study also demonstrates that short arm-wrist immobilsing casts are an effective option for managing triquetral fractures.
An update on the management of nerve gaps
Authors: Alexander William , Coombs Christopher
Published: March 2020

No abstract required
Incisional negative pressure wound therapy in bilateral breast reductions patients
Authors: Savage Nicholas , Jain Mohit , Champion Robert , Snell Broughton
Published: March 2020

Introduction: Incisional negative pressure wound therapy (iNPWT) has been applied to bilateral breast reduction patients and shown a reduction in surgical complications. However, its effects on opioid use and hospitalisation length in this patient group has not been investigated.Methods: In this single surgeon retrospective cohort study, 52 patients who underwent bilateral breast reduction were analysed, with 23 patients in the iNPWT cohort and 29 in the standard-of-care (SOC) wound dressing cohort. Hospitalisation length, postoperative opioid use and surgical site complications were compared between cohorts. Mean (range) follow-up time was 369.15 (77-1329) days.Results: Hospitalisation length in days was significantly less in the iNPWT cohort (1.35) than the SOC cohort (2.03). Total ward opioid use was significantly reduced in the iNPWT cohort (45.50mg) compared to the SOC cohort (62.50mg). Discharge opioid prescription was significantly reduced in the iNPWT cohort (125.50mg) compared to the SOC cohort (230.00mg). The number of surgical site complications was significantly different between the groups (p=0.014).Discussion: This study suggests the use of iNPWT in bilateral breast reduction provides significant benefit through the reduction of hospitalisation, complications and opioid use. Conclusion: This is the first study to provide evidence for iNPWT in bilateral breast reduction in reducing postoperative opioid use and hospitalisation. It supports current literature showing a reduction in surgical site complications using iNPWT in bilateral breast reduction.
How can AHPRA improve compliance of health practitioner advertising?
Authors: Atkin Jodie
Published: March 2020

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Ikigai: a balanced life in plastic surgery
Authors: Lee Mark , Ashton Mark
Published: March 2020

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The overview of mechanical properties of short natural fiber reinforced geopolymer composites
Authors: Korniejenko Kinga , łach Michał , Doğan Sağlamtimur Neslihan , Furtos Gabriel , Mikuła Janusz
Published: March 2020

In the EU there is a pressing need for the change of the current economy into a so-called circular economy in recent years. The rational management of natural resources and the use of waste materials are becoming more and more important. It is also supported by the growing ecological awareness of society, including the consciousness of sustainable development. Nowadays, it is the construction industry that has the most significant impact on pollution. Therefore, numerous attempts are made to reduce energy consumption and the amount of waste generated by it. These are the main issues stimulating the research on new innovative materials such as geopolymer composites. They have a significantly lower carbon footprint than traditional construction materials. Moreover, the synthesis of geopolymers requires 2-3 times less energy than traditional Portland cement, not to mention the fact that 4-8 times less CO2 is generated. In addition, the above process has another environmental benefit i.e. the possibility of using anthropogenic raw materials (minerals) such as slags and fly ashes for the production. One of the limitations for the wide use of such materials is their relatively low brittle fracture behaviour. Nowadays, one of the most important research areas is the improvement of their mechanical properties. To improve the mechanical properties it is possible to reinforce the matrix by fibres addition, especially natural fibres that are renewable resources. The main objective of the article is to analyse the mechanical properties of new composites and assessment the possibility to replace traditional building materials within eco-friendly alternatives.
La bioética como herramienta para enfrentar el bullying en la Educación Básica Regular
Authors: Ruiz Alvarado José Rogelio
Published: March 2020

En cualquier situación que un país enfrente y represente una problemática social, la educación será siempre una de las mejores armas de lucha para acabar con ella. La Educación Básica Regular en el Perú, ha cambiado en las últimas décadas, ahora ya no se restringe solamente a la adquisición de contenidos curriculares, sino que ahora cuenta con los llamados ejes transversales, que se convierten en un trasfondo del proceso educativo incluyendo así temas con relevancia social y orientados a la difusión de los valores y principios buscando siempre el bien común.

Los estudiantes de EBR enfrentan, además de sus propias responsabilidades académicas y los cambios propios de su etapa, una gran problemática: el acoso escolar o más conocido Bullying, el cual a través de sus distintas manifestaciones atentan directamente contra la dignidad humana de cada estudiante.

La interiorización que realizarán los estudiantes de los principios bioéticos gracias a la transversalidad en los planes educativos, permitirá que ellos mismos identifiquen qué situación representa alguna vulneración o lesión de su dignidad humana y tomar las medidas para superarlas con la ayuda de las personas preparadas para ello.
De la familia a la Biofamilia
Authors: Jiménez Carbajal Alicia Ruth
Published: March 2020

El término Biofamilia se puede considerar un neologismo necesario para los estudios e investigaciones acerca de la familia. Ésta, con sus costumbres y comportamientos también adquiere interés desde la ética. De la ética aplicada a la familia surge el término biofamilia, el cual hace referencia al primer grupo de vida, donde la persona se humaniza. La globalización ha permitido que ingresen ideologías que le quitan a la familia natural el lugar que le corresponde, las políticas públicas deben considerar la estructura y funcionamiento de la biofamilia como fundamento para el desarrollo de la sociedad. La relativización del concepto de familia por parte de los organismos supranacionales ha contribuido a aumentar la confusión. El desarrollo del concepto de biofamilia, en los ambientes académicos y de investigación permitirá no desvirtuar el concepto de familia.
Percepción del adulto mayor sobre su interrelación familiar. Sector II del distrito La Victoria-Chiclayo-2018
Authors: Peña Soplapuco Delia , Pizarro Coronado Luz Bella , Constantino Facundo Francisca
Published: March 2020

La presente  investigación es de tipo cualitativa con abordaje metodológico de estudio de caso el cual  tuvo como objetivo describir, analizar y comprender la percepción del adulto mayor sobre su interrelación familiar. Sector II del distrito La Victoria-Chiclayo-2018. Los sujetos de investigación fueron 15 adultos mayores, y 15 familiares que viven con el adulto mayor, ambas muestras fueron determinadas por la técnica de saturación y redundancia, para la recolección de datos se utilizó la entrevista semiestructurada que fue validada por juicio de expertos. Estos datos se procesaron a través del análisis de contenido temático obteniéndose cuatro categorías: El adulto mayor y su relación familiar, Apoyo de los hijos como parte importante de la relación familiar,  Sintiéndose útil: Participación del adulto mayor en las actividades del hogar y Actuación del adulto mayor como consejero en la familia. En todo momento de la investigación se tuvo en cuenta los criterios de rigor éticos y científicos. Concluyendo que  la mayoría de  adultos mayores y  familiares consideran a  la relación  familiar como buena salvo algunas excepciones y refieren  que para que exista esta buena relación es  importante que estén los elementos de afecto, comunicación y compañía los cuales deben estar entrelazados uno de los otros, también el  apoyo de los hijos a los padres es  importante, como el permitir que el adulto mayor realice actividades dentro del hogar y lo más relevante es que son considerados  como consejeros y orientadores en el seno familiar.

Palabras claves: Percepción, anciano, interrelación, familia
Aportes a la formación del talento humano desde la filosofía de la educación de pensadores peruanos representativos
Authors: Melèndez Ilatoma Antonio
Published: March 2020

Para que la educación sea de calidad, se debe mejorar factores económicos y de gestión, así como fortalecer y desarrollar las distintas potencialidades del estudiante, es decir, el talento humano. En perspectiva de la investigación científica educacional en Perú, son escasos los estudios sobre el impacto económico, la gestión o tarea educativa en el desarrollo nacional, así como, también investigaciones de historia, filosofía y filosofía de la educación. Por ello, este proyecto de investigación formativa busca rescatar las ideas filosóficas de pensadores peruanos relacionadas con la formación del talento humano de tal manera, que se sustente filosóficamente en los aportes de autores peruanos representativos que han ayudado a la elaboración y construcción de una filosofía de la educación peruana referida a la formación del talento humano.
“Amo porque amo, Amo por amar”. La evidencia y la tarea
Authors: Bravo Díaz César Eduardo
Published: March 2020

La presente entrega forma parte de uno de los libros básicos de entre las principales colecciones editadas por el ahora Instituto Teológico Juan Pablo II para estudios sobre el matrimonio y la familia (Roma), impreso en el 2007 y profundamente vigente para los estudios actuales sobre el tema. Esto precisamente porque el autor afirma aunarse a la intención de reflexionar sobre el amor, el matrimonio y la familia desde la base de las dos ramas filosóficas más apeladas en las últimas décadas: la antropología y la ética, revelando así su profundo interés de participar del estilo reflexivo de Juan Pablo II y el Cardenal Angelo Scola, en lo que llamará la antropología del misterio nupcial.
Relaciones entre el Estado y las confesiones religiosas en España. Apuntes históricos y regulación actual a la luz de la jurisprudencia del Tribunal Europeo de Derechos Humanos
Authors: Cañamares Arribas Santiago
Published: March 2020

Hasta la entrada en vigor de la Constitución, el modelo constitucional de relaciones Iglesia-Estado se caracterizó, salvo algunas breves excepciones, por la confesionalidad católica. Bajo el actual régimen constitucional se ha instaurado un régimen de laicidad positiva que viene enmarcado por el principio de cooperación entre el Estado y las confesiones y que sirve, a su vez, como garantía de la libertad religiosa.
DEL ACTIVISMO A LA DEMIURGIA JUDICIAL: ¿CUÁL ES EL VALOR REAL DE UN TRATADO INTERNACIONAL DE DERECHOS HUMANOS?
Authors: Bazán José Luis
Published: March 2020

La práctica, cada vez más extendida en los tribunales internacionales de derechos humanos, de superar la letra y el espíritu de los tratados internacionales que han de interpretar, y de reconfigurar unilateralmente  su contenido obligacional sin respetar los procedimientos previstos de reforma, está modificando sustancialmente el derecho internacional de los derechos humanos. La interpretación se convierte, de este modo, en una práctica demiúrgica que crea ex novo y sin fundamento legal nuevos derechos (o incluso, pretendidos e inexistentes “derechos”) que no sólo no se contienen en los tratados, sino que, en no pocos casos, pueden minar seriamente el contenido sustancial de derechos explícita y generalmente reconocidos como fundamentales. La incertidumbre jurídica y los altos riesgos de interpretación ideológica y arbitraria de los derechos que genera este activismo judicial se añaden a la vulneración de principios tan básicos como el consentimiento del Estado Parte como fuente de obligaciones internacionales convencionales. La integridad de los derechos humanos exige que los tribunales internacionales abandonen tales prácticas arbitrarias, respeten los límites de su mandato interpretativo otorgado y dejen de operar de facto y abusivamente como órganos legisladores