bluuebunny/crossref_metadata_2025 huggingface dataset:
Upotreba Kaizen filozofije u upravljačkim strukturama kompanija u Srbiji / The Use of Keizen Philosophy in the Managing Structures in the Companies in Serbia
Authors: Žikić Simona
Published: May 2023

In the moment when there is a question mark over the economy of every country and the markets are not stable, but ever changing, moving forward, and/or collapsing, one of the most successful approaches to the survival and improvement of the management of the companies is Keizen concept. Keizen concept of management is philosophy that is initially used in Japan, where it comes from, but in other places all around the world as well, mostly in America and the countries in Western civilization. Keizen philosophy is the concept of continuous improvement, which, strategically observed, contributes improvement and prosperity of the companies. Having in mind its occurrence, the first results of Keizen philosophy’s approach can be identified in the development of Japanese economy, which reached unbelievable results and improvement only few years after the Second World War. Japanese companies very soon became competitive at the global market thanks to Kaizen philosophy, no matter the fact that his approach includes managing concepts and concepts of business organization which are diametrically opposite to the current dominant opinion and application of the concepts of managing business organization from the Western companies. This is the reason why the idea of this paper is to show the main values that are in the core of Kaizen philosophy and to show that the application of this business concept is possible in Serbia, besides the small number of those who already did it. The aim of this paper is to bring closer the importance of the development of human resources and their influence on the structure of the companies’ management, because only with the human resources department based well, there is a possibility of Keizen philosophy application.
Book Review: Rađanje evropske modernosti i Đordano Bruno – recenzija knjige Aleksandre Mančić Đordano Bruno i komunikacija: prevođenje ideja
Authors: Đurić Dubravka
Published: May 2023

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Discourses on Woman/Body and the Politics of Movement in Ballet, Dance and Hip-Hop
Authors: Pejović Marko
Published: May 2023

The aim of this study is to point out the relationship of ballet, modern dance and hip-hop towards the female body. The main question that the text deals with is whether ballet, modern dance and hip-hop and their politics of movement have only maintained or have also significantly influenced the discourses on the body and women. To what extent have these practices utilized the mechanism of splitting in generating a monolithic matrix of the female body, and how much has such a matrix been a basis for controlling and disciplining the female performer? What means have individual authors used when stepping away from existing models of body-incorporation, namely the submission of the body to the dominant systems of power within these practices? These questions will be treated through examples of work by Maguy Marin, Yvonne Rainer and Major Lazer.
Perfil neurocognitivo y afectivo en personas con esquema maladaptativo temprano de abandono / pérdida
Authors: Álvarez Posada José Luis
Published: May 2023

El articulo presenta resultados de la investigación dirigida a describir el perfil neurocognitivo y afectivo en participantes con esquema maladaptativo temprano de abandono / pérdida, en edades comprendidas entre 20 y 40. Se empleó una metodología cuantitativa del nivel descriptivo, la muestra estuvo conformada por 12 participantes controles (sin ningún tipo de diagnóstico neurológico, neuropsicológico ni esquema maladaptativo temprano de abandono / pérdida) y 12 participantes sin ningún tipo de diagnóstico neurológico, neuropsicológico pero con presencia de esquema maladaptativo temprano de abandono / pérdida. Se encuentra entonces que el perfil neurocognitivo de los participantes con EMT de abandono / pérdida, difiere significativamente del perfil de los participantes que no presentan dicho EMT, pues se hallaron diferencias estadísticamente significativas en comprensión, semejanzas, memoria figura compleja de Rey y palabra color (Stroop). Específicamente los participantes con EMT A/P presentaron un desempeño superior en dichas variables y una mayor predisposición a desarrollar cuadros depresivos y de ansiedad bajo ciertas circunstancias de separación y abandono.
Relación entre perfil neurocognitivo y depresión y ansiedad en pacientes con diagnóstico de esclerosis múltiple de subtipos primaria progresiva y remitente recurrente
Authors: Villa Londoño Antonio Jose
Published: May 2023

El articulo presenta resultados de la investigación dirigida a correlacionar el perfil neuropsicológico de 22 pacientes con diagnóstico de esclerosis múltiple, de los cuales 13 pacientes con subtipo primaria progresiva y 9 pacientes con subtipo remitente recurrente (Arana, M. 2011), con ansiedad y depresión. A los 22 pacientes a quienes se les aplico la batería neuropsicológica, la cual permitió determinar dicho perfil, se les aplico los test de depresión y ansiedad de Beck. Por tanto, se cruzaron las variables diagnósticas (Esclerosis Múltiple, y Sujetos Sanos) con las variables psicológicas (Ansiedad y depresión) para establecer la comparación y la descripción de las mismas (N, media, desviación estándar), de acuerdo a los grupos establecidos (Personas con diagnóstico de esclerosis: progresiva primaria y remitente recurrente). Esto se llevó a cabo por medio del software estadístico SPSS 19.0. Hallando que, en cuanto a las variables sociodemográficas, se observan correlaciones entre los años de educación y la variable de ansiedad, siendo esta relación moderada e inversamente proporcional. Para la variable de depresión se observa relación con la variable años de educación, aunque es una relación débil también tiene una direccionalidad inversamente proporcional. En cuanto a las variables tenidas para la medición del perfil neurocognitivo, se encuentra que la población se presenta con una distribución normal, se utiliza la diferencia entre medias, donde se encuentran diferencias estadísticamente significativas para la ansiedad, siendo mayor esta diferencia en el grupo de esclerosis progresiva primaria; mientras que la depresión no indica diferencias estadísticamente significativas, rechazando la hipótesis planteada. Se encuentra específicamente alteración en el perfil neurocognitivo en la función atencional pues se evidencia que la variable de atención Test de Símbolos y Dígitos Oral presenta diferencias estadísticamente significativas con relación a la ansiedad siendo mayor esta diferencia en el grupo de personas con un alto grado de ansiedad. La variable Test de Símbolos y Dígitos Escrita, presenta de igual modo diferencias estadísticamente significativas. De otra parte se encuentran alteraciones en las funciones ejecutivas, pues una de las variables donde se encuentran diferencias estadísticamente significativas con relación a la ansiedad asumiéndose la no igualdad de varianzas es la variable de función ejecutiva PASAT P2, siendo mayor esta diferencia en el grupo de personas con un alto grado de ansiedad, y la variable función ejecutiva PASAT P3.
Editorial Vol. 8 N 12
Authors: Klimenko Olena
Published: May 2023

Editorial Vol. 8 N 12
The Contribution of Photon, Z Boson, Higgs, Radion and Unparticle to the Process in Randall-Sundrum model
Authors: Mai Dung Le , Thi Le Thuy Dao
Published: May 2023

The process is studied from unparticle physics perspective in Randall-Sundrum model. We calculated and evaluated the cross sections independently for photon (γ), Z boson (Z), vector unparticle (Uμ), Higgs (h), radion ( ), scalar unparticle (U) exchange. Numerical calculations showed that the contribution of unparticle exchange dominates in a very high energy region. While γ and Z contribute mainly in the lower region, h and contribution is negligible in comparison with the other exchanges. The results are plotted in the energy ranges available in the present designs of accelerators and near future high energy frontier muon colliders as shown by International Muon Collider Collaboration articles.

Keywords: Muon production, unparticle physics, collisions, muon colliders, Randall-Sundrum model.
Enhancement of Magnetic Field Strength and Gradient Produced by an Array of Micro-sized Parallelepiped Magnets
Authors: Tiep Nguyen Huy , Tu Bui Dinh , Cuong Le Viet
Published: May 2023

In this work, we carried out survey on magnetic field strength and gradient in space around arrays of micro-sized parallelepipedic magnets by simulation and calculation. Magnetic field distributions are a function of magnet’s size and position with respect to magnet’s surface. Our purpose is to explain how magnetic interactions evolve while dimensions of magnetic sources are reduced. Firstly, the simulations and calculations were executed for a magnet with a large surface size of 1,000×1,000 µm2, a thickness of 5 µm, and a residual magnetism of 1.6T perpendicular to its surface. Then, the similar works were also performed for arrays of magnets with smaller surface sizes, e.g. 1,000×500 µm2; 1,000×200 µm2; 1,000×100 µm2; 1,000×50 µm2 and 1,000×10 µm2. Consequently, both the magnetic field strength and gradient in the space which is above and near the surface of the magnets, particularly, the space from the surface of the magnets to the height of 100 µm far from the surface of the magnets, were enhanced when the magnets’ size were appropriately reduced. This suggests that the application field of the magnets will be expanded and their integration into microsystems will be grown as the size of the magnets is reduced.
Effect of Confined Optical Phonons on Photo-Stimulated Ettingshausen Effect in Rectangular Quantum Wires with A Perpendicular Magnetic Field
Authors: Nguyet Anh Nguyen Thi , Tung Luon Van , Bau Nguyen Quang , Dien Tang Thi
Published: May 2023

We applied the quantum kinetic equation method to investigate the influence of confined optical phonons (confined OP) on the photo-stimulated Ettingshausen effect in rectangular quantum wires (RQW) subjected to a perpendicular magnetic field. We considered the case where the confined electrons-confined OP scattering is the dominant mechanism. Analytical expressions for the kinetic tensors, the EC are obtained. The EC is a function of external fields, the temperature of the system, especially the quantum numbers m1 and m2 characterizing confined OP. When the width of the wire increases to infinity, the results of the bulk semiconductors can be gained. The numerical results are numerically evaluated and discussed for the GaAs/AlGaAs RQW. The magnitude of the resonance peaks has been increased for each value of m1, m2, found when examining the dependence of the EC on the photon energy. Furthermore, the EC is decreased considerably when the amplitude of EMW increases, which is obtained when investigating the dependence of the EC on the amplitude of EMW (laser). These results are important for further researches and could be helped to complete the theory of the thermo - magnetoelectric effects in the low dimensional system.
Enhancing Poly(3,4-ethylenedioxythiophene) Polystyrene Sulfonate (PEDOT:PSS) Conductivity by Dimethyl Sulfoxide (DMSO) Dopant
Authors: Xuan Hao Nguyen , Nhat Minh Nguyen , Duc Anh Ngo , Le Ngoc Thu Nguyen , Ngoc Duy Huynh Ha , Gia Man Nguyen Bui , Nhat Giang Doan , Hoai Nhan Luong , Vinh Quang Dang
Published: May 2023

Poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), a type of conducting polymer has caught lots of attraction from scientists for its excellent properties as low-cost, non-toxic, etc. This also is a potential material for various applications as transparent electrodes, flexible and stretchable devices, thus improving the electrical properties of this polymer plays an important role. Among various methods such as post-treatment, doping with glycerol, and d-sorbitol herein, DMSO was chosen as an additive to enhance the conductivity of PEDOT:PSS. The results, including the increase in the films conductance according to the rise of DMSO dopant ratio from 0 to 2, good transmittance and surface morphology were clearly presented. This will be the platform for the further study of the utilization of PEDOT:PSS in various potential optoelectronic devices in the future.
Efficacy of inhaled Desmopressin in pregnant women with idiopathic oligohydramnios – a randomized controlled trial
Authors: LotfAlizadeh Marziye ,   Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, MoeinDarbari Somayeh ,   Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, MohebbanAzad Neshat ,   Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran, Ghomian Nayereh ,   Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran,   * Corresponding Author: Nayereh Ghomian, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. E-mail: Ghomiann@mums.ac.ir
Published: May 2023

The aim of this study was to investigate the therapeutic effect of inhaled Desmopressin (DDAVP) in pregnant women with idiopathic oligohydramnios. This randomized, double-blind clinical trial involved 44 pregnant women at 28–37 weeks of gestation with idiopathic oligohydramnios admitted in 2 academic hospitals in Mashhad, Iran, from 2018 to 2019. In the intervention group, 10µg DDAVP was nasally sprayed. The control group received intravenous maintenance fluid. The hematocrit, electrolytes, blood pressure and urine-specific gravity were evaluated at baseline and 3, 8, and 24 hours later. Amniotic fluid index (AFI) was measured using ultrasound at baseline, 24 and 48 hours later. There was no significant difference in the basic characteristics (age, body mass index, and gestational age) between the two groups. The pattern of changes of AFI (baseline, 24 and 48 hours later) increased in the intervention (4.16±0.86, 7.08±1.453 and 7.76±1.62, p<0.001) and control groups (4.23±0.70, 5.39±1.079 and 5.68±1.10, p<0.001). Serum sodium levels significantly declined in the intervention group (p<0.001) but not in the control group (p=0.07). There were no significant differences in potassium (p=0.89), hematocrit (p=0.23), systolic blood pressure (p=0.21) and diastolic blood pressure (p=0.97). However, urine-specific gravity had an increasing pattern in the intervention group (p<0.001) and a decreasing pattern in the control group (p<0.001). This study showed that Desmopressin inhalation could increase the AFI and urine specific gravity, enhancing oligohydramnios treatment in pregnant women, compared to serum administration.
Investigating the efficacy of Ginkgo biloba on the cognitive function of patients undergoing treatment with electric shock: a double-blind clinical trial
Authors: Nazarinasab Masoumeh ,   Department of Psychiatry, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran,   * Corresponding Author: Masoumeh Nazarinasab, Department of Psychiatry, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. E-mail: nazarinasab-m@ajums.ac.ir, Behrouzian Forouzan ,   Department of Psychiatry, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Negahban Saeedeh ,   Department of Psychiatry, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Sadegh Amirali Moghadam ,   Department of Psychiatry, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, Zeynali Elham ,   Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Published: May 2023

Cognitive impairment is common in patients undergoing electroconvulsive therapy (ECT). Researchers are seeking pharmaceutical compounds with low side effects to decrease these outcomes. This study aimed to investigate the effectiveness of Ginkgo biloba therapy on the cognitive function of patients treated with electroshock. In a double-blinded clinical trial, 80 patients with psychiatric disorders who were candidates for ECT in 2019 were randomly assigned to two groups: the intervention group (receiving Ginkgo biloba drug) and the control group (receiving placebo). We used the Mini-Mental State Examination (MMSE) and Wechsler Memory Scale Recipe III (WMS-III) questionnaires to evaluate the efficacy of the drug on the cognitive function at time 0, after 4 sessions and 72 hours post-final session of ECT. The data were analyzed by SPSS version 22, with a significance level of 0.05. Patients' assessment after the intervention showed that the average MMSE scores in the intervention group (28.92±1.04) were statistically higher than in the control group (27.85±1.56). The average scores of the WMS-III in the intervention group and the control group were 97.45±8.04 and 92.00±4.45 after 4 sessions of ECT, and 100.26±8.33 and 92.40±3.92 after the intervention (p=0.001). According to the findings, Gingko biloba increased MMSE and WMS-III scores in older patients (patients over 40 had better scores in both questionnaires, the drug was more effective, and with no side effects).
The effect of mindfulness-based stress reduction (MBSR) training on serum cortisol levels, depression, stress, and anxiety in type 2 diabetic older adults during the COVID-19 outbreak
Authors: Sayadi Ahmad Reza ,   Department of Psychiatric Nursing, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran,   Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran, Bagheri Seyed Hamid Seyed ,   Department of Pediatric and Neonatal Nursing, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran,   Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran, Khodadadi Ali ,   Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran,   Department of Medical Surgical Nursing, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran, Torababadi Reza Jafari ,   Department of Geriatric Nursing, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran,   * Corresponding Author: Reza Jafari Torababadi, Department of Geriatric Nursing, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. E-mail: sayadiahmad@yahoo.com
Published: May 2023

Old age is rapidly increasing and is linked to with chronic diseases, especially diabetes. Diabetes is associated with increased anxiety, stress, and depression and, in turn, can increase cortisol secretion. To this end, the present research studied the impact of mindfulness-based stress reduction (MBSR) training on serum cortisol levels, depression, anxiety, and stress in type 2 diabetic (T2DM) older adults during the COVID-19 epidemic. The participants in this interventional work were 56 older adult patients with type 2 diabetes chosen through systematic random sampling and then randomly divided into control and intervention groups containing equal members. In the intervention group, the participants attended eight mindfulness-based stress reduction (MBSR) training sessions. The subjects in the control group received no intervention. Since four patients left the study, only data for 52 patients were collected using the Depression Anxiety Stress Scale (DASS-21) and a demographic and disease information questionnaire. Data were examined with SPSS18 software using the Kolmogorov-Smirnov test, chi-square test, Fisher test, independent samples t-test, and two-way ANOVA; the significance was p<0.05. Statistically significant differences were observed between the mean scores of anxiety, stress, depression, and cortisol levels in the intervention group (p<0.00001) before, directly after, and three months after the intervention. However, no statistically significant difference was observed in the mentioned variables in the control group. The mindfulness-based stress reduction (MBSR) intervention can improve anxiety, depression, stress, and cortisol levels in older adults suffering from T2DM.
The effect of serum uric acid concentration on the severity of chronic congestive heart failure
Authors: Alshamari Ali Hasan Ismaeel ,   Department of Medicine, College of Medicine, Kufa University, Kufa, Iraq,   * Corresponding Author: Ali Hasan Ismaeel Alshamari, Department of Medicine, College of Medicine, Kufa University, Kufa, Iraq. E-mail: alihasan200872@yahoo.com, Kadhim Rossal Kamil ,   Department of Medicine, College of Medicine, University of Babylon, Babylon, Iraq, AL-Mohana Sadiq Jebar Ali ,   Department of Medicine, College of Medicine, Kufa University, Kufa, Iraq
Published: May 2023

This study aimed to investigate the adverse effects of serum uric acid concentration on the severity of chronic congestive heart failure. One hundred patients with chronic congestive heart failure (several risk factors include hypertension, smoking, and diabetes mellitus) were enrolled in this study (51 females and 49 males). Participants were admitted to Alsader Medical City in Al-Najaf from August 2018 to March 2019. Detailed medical history and complete clinical examination were performed for all patients. The patients' ages ranged from 13–90 years, with a mean of 62.1±15.8 years, and the median was 65 years. No statistically significant age difference was observed between males and females (P-value=0.687). Increased serum uric acid had a directly negative effect on the severity of chronic congestive heart failure and hypertension. High serum uric acid concentration was associated with increased severity of chronic congestive heart failure class NYHA III and NYHA IV and a decrement in ejection fraction of the left ventricle.
Assessment of thyroid function tests in patients with chronic obstructive pulmonary disease
Authors: Alshamari Ali Hasan Ismaeel ,   Department of Medicine, College of Medicine, University of Kufa, Najaf, Iraq,   * Corresponding Author: Ali Hasan Ismaeel Alshamari, Department of Medicine, College of Medicine, University of Kufa, Najaf, Iraq. E-mail: alihasan200872@yahoo.com, Deli Falah ,   Department of Medicine, College of Medicine, University of Kufa, Najaf, Iraq, Kadhum Hesham Ibrahim ,   Babylon Health Directorate, Alsadiq Teaching Hospital, Babylon, Iraq, Kadhim Iman Jabar ,   Department of Community Medicine, College of Medicine, University of Kufa, Najaf, Iraq
Published: May 2023

Chronic obstructive pulmonary disease (COPD), a group of diseases of distinct aetio-pathological consideration with different phenotypic presentations where smoking is the leading cause, all share the ultimate result of airflow limitation. This study aimed to evaluate thyroid function tests (TFT) in patients with COPD. Pulmonary function tests (PFT) were performed for 30 patients with obstructive lung disease and fifteen healthy control individuals. We measured SPO2 to confirm COPD and assess the severity of the disease and assessed TT3, TT4, and TSH using the ELISA test. The values of VC, FVC, and FEV in the first second and PEF, TSH, and SPO2 were lower in the COPD group than in the control group (P-value=0.001). In severe COPD (FEV1<50%), there was a significant reduction in T3 but not T4 or TSH compared to mild-moderate COPD patients. Thyroid dysfunction was observed in patients with COPD pointing to a metabolic response; patients with lower weight indices had a lower TSH and, consequently, T3.
125 years of the Wertheim operation. What next?
Authors: Drouin Emmanuel ,   Neurology Service, Lille Catholic Institute Hospital Group, Lomme cedex, France,   * Corresponding Author: Emmanuel Drouin, Neurology Service, Lille Catholic Institute Hospital Group, Lomme cedex, France. E-mail: emmanuel.drouin@univ-catholille.fr, Classe Jean-Marc ,   Ouest Cancer Institute, Saint Herblain, France,   Department of Cancerology, Medical University, Nantes, France, Hautecoeur Patrick ,   Neurology Service, Lille Catholic Institute Hospital Group, Lomme cedex, France
Published: May 2023

The Austrian gynecologist Ernst Wertheim (1864-1920) was a pioneer in the surgical treatment of cancer. The principle of Wertheim’s hysterectomy was to remove the uterus and the cervix with appropriate parametrium and tissues surrounding the upper vagina and pelvic lymph nodes. However, in the early 2000s, a meta-analysis of randomized trials revealed that radiotherapy and concomitant chemotherapy without surgical removal of the uterus were more effective in the historical treatment of advanced cervical cancer. This finding challenged the use of radical abdominal hysterectomy (RAH) in such cases and demonstrated the superiority of radiotherapy and chemotherapy in terms of overall survival.
In vitro and in vivo antidiabetic activity of bitter honey in streptozotocin-nicotinamide-induced diabetic Wistar rats
Authors: Koodathil Joshna ,   Department of Pharmacognosy, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India,   * Corresponding Author: Joshna Koodathil, Department of Pharmacognosy, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India. E-mail: joshnak4@gmail.com, Venkatachalam Gopal ,   Department of Pharmacognosy, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India, Bhaskaran Kavitha ,   Department of Pharmacognosy, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India
Published: May 2023

Diabetes mellitus is a metabolic syndrome considered one of the life-threatening diseases in the last two decades. This research aimed to investigate the anti-diabetic potential of bitter honey collected from Nilgiris using both in vitro and in vivo methods. The mineral content of bitter honey was also estimated using atomic absorption spectrophotometer. Bitter honey had a higher amount of zinc and copper, while heavy metals like lead, nickel, and cadmium were below the detection limit. The in vitro antidiabetic study was performed using alpha-amylase and alpha-glucosidase inhibition methods. Acute toxicity (OECD 423) was conducted in female Wistar rats to determine the lethal dose of bitter honey. The antidiabetic activity was carried out in type-2 diabetic Wistar Albino rats induced with streptozotocin and nicotinamide. The experimental rats were categorized into five groups (n=8): the normal group, the diabetic control group, standard glibenclamide-treated diabetic group, bitter honey 200 mg/kg, and 400 mg/kg b.w. treated diabetic group. After the treatment period (28 days), blood samples were collected for biochemical studies, and the pancreas was dissected for histopathological studies. The in vitro antidiabetic studies revealed the antidiabetic potential of bitter honey compared to standard acarbose. Treatment of diabetic rats with bitter honey revealed a statistically significant reduction (P<0.05) in the levels of fasting blood glucose (FBG) compared to untreated diabetic rats. This was accompanied by an elevated HDL and a decrease in LDL, VLDL, triglycerides, total cholesterol, SGOT, SGPT, urea, and creatinine. Histopathological changes in the pancreas indicated a marked improvement in a dose-dependent manner. The study concluded that bitter honey could potentially decrease the levels of FBG in diabetic rats and the various biochemical and histopathological abnormalities associated with diabetes mellitus.
Breast cancer relapses considering molecular biological characteristics
Authors: Smolanka Ivan Ivanovich ,   National Cancer Institute, Ministry of Health, Kyiv, Ukraine, Movchan Oleksii Volodimirovich ,   National Cancer Institute, Ministry of Health, Kyiv, Ukraine, Bagmut Irina Yuriivna ,   Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine, Sheremet Michael Ivanovich ,   Department of Surgery No.1, Bukovinian State Medical University, Chernivtsi, Ukraine,   * Corresponding Author: Michael Ivanovich Sheremet, Department of Surgery No.1, Bukovinian State Medical University, Chernivtsi, Ukraine. E-mail: mihayl71@gmail.com, Kolisnyk Igor Leonidovich ,   Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine, Dosenko Irina Viktorivna ,   National Cancer Institute, Ministry of Health, Kyiv, Ukraine, Lyashcnko Andriy Oleksandrovich ,   National Cancer Institute, Ministry of Health, Kyiv, Ukraine, Ivankova Oksana Mykolaivna ,   National Cancer Institute, Ministry of Health, Kyiv, Ukraine, Loboda Anton Dmitrovich ,   National Cancer Institute, Ministry of Health, Kyiv, Ukraine, Shidlovskyi Oleksandr Viktorovich ,   Department of Surgery, Ivan Horhachevsky Ternopil National Medical University, Ternopil, Ukraine
Published: May 2023

We aimed to analyze the frequency of breast cancer relapses and their relationship with molecular and biological tumor characteristics. We studied 6,136 breast cancer patients, including 146 with relapses (Group 1) and 455 without relapses (Group 2). We divided the patients based on age, menstrual function, disease stage, histology form and grade, and molecular-biological subtype. The 5-year relapse-free rate for Group 1 was longer for Lum A and TN subtypes (60% and 40%, respectively) but shorter for Lum B and HER-2/neu-amplified subtypes (38% and 31%, respectively). Disease stage, tumor histology, and grade did not significantly affect relapse frequency in these patients. Relapses were more common in premenopausal patients and the Lum B subtype.
HER2/positive and HER2/low in inflammatory breast cancer recurrence
Authors: Movchan Oleksii Volodimirovich ,   National Cancer Institute, Ministry of Health, Kyiv, Ukraine, Bagmut Irina Yuriivna ,   Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine, Shipko Andriy Fedorovich ,   National Cancer Institute, Ministry of Health, Kyiv, Ukraine, Smolanka (Senior) Ivan Ivanovich ,   National Cancer Institute, Ministry of Health, Kyiv, Ukraine, Sheremet Michael Ivanovich ,   Department of Surgery No.1, Bukovinian State Medical University, Chernivtsi, Ukraine,   * Corresponding Author: Michael Ivanovich Sheremet, Department of Surgery No.1, Bukovinian State Medical University, Chernivtsi, Ukraine. E-mail: mihayl71@gmail.com, Kolisnyk Igor Leonidovich ,   Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine, Bagmut Oleksandr Vasyliovych ,   Faculty of Computer Sciences, Karazin Kharkiv National University, Kharkiv, Ukraine, Lyashenko Andriy Oleksandrovich ,   National Cancer Institute, Ministry of Health, Kyiv, Ukraine, Loboda Anton Dmitrovich ,   National Cancer Institute, Ministry of Health, Kyiv, Ukraine, Ivankova Oksana Mykolaivna ,   National Cancer Institute, Ministry of Health, Kyiv, Ukraine, Dosenko Irina Viktorivna ,   National Cancer Institute, Ministry of Health, Kyiv, Ukraine, Lazaruk Oleksandr Volodimirovich ,   Department of Pathology, Bukovinian State Medical University, Chernivtsi, Ukraine, Gyrla Yan Viktorovich ,   Department of Surgery No.1, Bukovinian State Medical University, Chernivtsi, Ukraine, Bilookyi Oleksandr Vyacheslavovich ,   Department of Surgery No.1, Bukovinian State Medical University, Chernivtsi, Ukraine
Published: May 2023

This study aimed to investigate the impact of HER2-low on the risk of recurrence in individuals with inflammatory breast cancer (IBC). 60 females with HER2-low and HER2-positive IBC underwent surgery between July 2020 and July 2022. Patients were divided into three groups of 20 patients: (1) HRplus/HER2-, (2) HRplus/HERplus, and (3) HR-/HER2plus. All patients underwent chemotherapy in adjuvant mode, following this scheme: TCH=docetaxel and carboplatin plus Herceptin (HER2 target – 4 mg/kg as the loading dose and 6 mg/kg as subsequent doses throughout every 21 days, entire 52 weeks of Herceptin therapy). HRplus/HERplus group had an OS of 76.9% compared with 77.0% in the group with the HRplus/HER2plus subtype and 74.4% in the HR-/HER2plus group. Moreover, recurrence-free survival was 19.1% for the HRplus/HER2-group, 21.3% for the HRplus/HERplus group, and 11.7% for the HR-/HER2plus group. In our study, patients with HER2-low IBC could acquire a perfect response with preliminary systemic therapy, without disease progression or with stable disease on target alone. Further examination is important to decide on the most effective treatment regimens, in addition to mixing chemotherapy with HER2-low-focused on agents.
A meta-analysis of normal human blood cholinesterase activities determined by a modified electrometric method
Authors: Garmavy Hishyar Mohammed Salih ,   Department of Pharmacology, College of Pharmacy, University of Duhok, Duhok, Iraq, Mohammed Ammar Ahmed ,   Department of Pharmacology, College of Pharmacy, University of Duhok, Duhok, Iraq, Rashid Hussein Mohammed ,   Department of Pharmacology, College of Pharmacy, University of Duhok, Duhok, Iraq, Mohammad Fouad Kasim ,   Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq,   * Corresponding Author: Fouad Kasim Mohammad, Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq. E-mail: fouadmohammad@yahoo.com
Published: May 2023

Measurements of blood cholinesterase (ChE) activities, including those of erythrocytes (EChE), plasma or serum (PChE), and whole blood (WBChE), are used to assess exposure to ChE-inhibiting pesticides. The purpose of this review was to report normal reference ChE activities in the blood of healthy adult humans, as determined by a modified electrometric method. We performed a systematic review following PRISMA guidelines. Single-group meta-analysis of means of PChE, EChE, and WBChE activities of adult healthy subjects was conducted using the random effects model. The programs used were Open-Meta Analyst and Meta-Essentials Version 1.5. Studies selected for analysis comprised 21, 19, and 4 reports of normal reference/baseline PChE, EChE, and WBChE activities in 690, 635, and 121 healthy adult males and/or females, respectively. The meta-analysis showed normal reference values of the means (effect sizes) with 95% CI of PChE, EChE, and WBChE activities of healthy adult subjects, which were 1.078 (1.015, 1.142), 1.075 (1.024, 1.125) and 1.331 (1.226, 1.436), respectively. By the subgroup analysis, heterogeneity (I2>89%) was considerably reduced in females to 4.4% and 30.1% for PChE and EChE, respectively. Funnel plots indicated no publication bias. However, Egger's regression confirmed the symmetry of the data points for PChE and WBChE activities with a significant effect on EChE. This meta-analysis showed normal reference values of PChE, EChE, and WBChE activities, measured by a modified electrometric method, in healthy adult humans.
Nicotine dependence and visceral adiposity as risk factors for the development and severity of carotid artery stenosis
Authors: Khazaal Mahmood Shaker ,   Department of Physiology, College of Medicine, Al-Nahrain University, Baghdad, Iraq, Hamdan Farqad Bader ,   Department of Physiology, College of Medicine, Al-Nahrain University, Baghdad, Iraq, Al-Mayah Qasim Sharhan ,   Medical Research Unit, College of Medicine, Al-Nahrain University, Baghdad, Iraq,   * Corresponding Author: Qasim Sharhan Al-Mayah, Medical Research Unit, College of Medicine, Al-Nahrain University, Baghdad, Iraq. E-mail: sciencefond2015@gmail.com
Published: May 2023

Nicotine dependence (ND) and visceral adiposity are emerging as independent risk factors for cardiovascular diseases, including carotid artery stenosis (CAS). This study aimed to determine the relationship between ND and the contribution of abdominal fat to the onset of CAS, which is indicated by a luminal narrowing of at least 60% as determined by duplex and/or Doppler ultrasound. We prospectively collected data from 60 patients with CAS and 60 age- and gender-matched healthy subjects. The Fagerström Test for Nicotine Dependence (FTND), a common research tool, was used in the study. The original questionnaire was designed to gather social and demographic data. Anthropometric measurements, visceral adiposity index (VAI), and lipid accumulation products (LAP) were used to assess obesity. Most patients showed a high or mild-moderate degree of ND: 46.67% and 35%, respectively. The median visceral adiposity index (VAI) and lipid accumulation product (LAP) in patients was 3.92 and 32.83, respectively. Prolonged smoking duration, increased intensity, and high ND are hallmarks of CAS patients.
The relationship between maternal health and neonatal low birth weight in Amman, Jordan: a case-control study
Authors: Sindiani Amer ,   Department of Obstetrics and Gynecology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan,   * Corresponding Author: Amer Sindiani, Department of Obstetrics and Gynecology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan. E-mail: amsindiani0@just.edu.jo, Awadallah Ekram ,   Department of Public Health, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan, Alshdaifat Eman ,   Department of Obstetrics and Gynecology, Faculty of Medicine, Yarmouk University, Irbid, Jordan, Melhem Shatha ,   Department of Obstetrics and Gynecology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan, Kheirallah Khalid ,   Department of Public Health, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan
Published: May 2023

This study aimed to examine the relationship between maternal health during pregnancy and low birth weight (LBW), as well as the impact of COVID-19 on the socio-economic status of pregnant women and its effect on LBW. The study was conducted in Amman, Jordan, and included 2260 mothers who visited Abu-Nusair comprehensive health center between January and December 2020. A matched case-control design was used with 72 cases and 148 controls selected for data collection through medical records and face-to-face interviews. Results showed that factors such as a monthly income of 400 JD or less, living with an extended family, exposure to passive smoking, maternal weight gain of 6–10 kg, maternal anemia, maternal hypertension, delivery by cesarean section, and previous history of LBW newborns were positively associated with an increased risk of LBW. Conversely, factors such as a monthly income above 700 JD, living with a core family, daily intake of iron, calcium, and vitamin D, prenatal visits, healthy food intake, and planning for pregnancy were associated with a lower risk of LBW. COVID-19 infection and its effects on work, family finances, antenatal care visits, and food supply were also positively linked with LBW. In conclusion, socioeconomic status, maternal health, COVID-19, and its impacts were significant risk factors for LBW.
Surgical treatment of liver echinococcosis
Authors: Yakubov Farkhod Radjabovich ,   Department of General Surgery, Urgench Branch of Tashkent Medical Academy, Urgench, Republic of Uzbekistan, Sapaev Duschan Shukhratovich ,   Department of General Surgery, Urgench Branch of Tashkent Medical Academy, Urgench, Republic of Uzbekistan,   * Corresponding Author: Duschan Shukhratovich Sapaev, Department of General Surgery, Urgench Branch of Tashkent Medical Academy, Urgench, Republic of Uzbekistan. E-mail: nodira.bakieva2221@gmail.com; duschanboy.sapaev@mail.ru
Published: May 2023

This article is based on the treatment results of primary and recurrent epidural infection among 1230 patients treated at three medical institutions: Khorezm Regional Multidisciplinary Medical Center, Clinic of Andijan State Medical Institute, Republican Specialized Scientific and Practical Medical Center for Surgery, between 2015–2020. The comparison group included 621 patients (from 2015 to 2017) who underwent a retrospective analysis. In comparison, the main group of the study included 609 patients (from 2018 to 2020). In the main group of patients, traditional echinococcectomy (EE) was performed in 80.1% of cases, LapEE in 12.3%, and PAIR and PEVAC techniques in 7.6%. The overall incidence of complications from the residual cavity in the comparison group was 36.4% after the PAIR technique, 39.1% after the PEVAC technique, 21.7% after LapEE, and 6.9% (37 out of 503) after traditional and resection EE. The proposed algorithm for selecting a method for treating exocrine pancreatic insufficiency (EPI) made it feasible to optimize tactical approaches to perform traditional and minimally invasive interventions, which ensured a decrease in the incidence of complications from the residual cavity and, accordingly, the need for repeated minimally invasive and open interventions and conservative therapy.
Evaluation of anti-atherosclerotic effects of Sitagliptin via modulation of the mTOR pathway in male rabbits
Authors: Sahib Hussam Hamza ,   Department of Clinical Laboratory Sciences, College of Pharmacy, University of Al-Qadisiyah, Diwaniya, Iraq, Mohammad Bassim ,   Department of Pharmacology and Therapeutics, College of Medicine, University of Al-Qadisiyah, Diwaniya, Iraq, Hadi Najah Rayish ,   Department of Pharmacology & Therapeutics, Faculty of Medicine, University of Kufa, Kufa, Iraq,   * Corresponding Author: Najah Rayish Hadi, Department of Pharmacology & Therapeutics, Faculty of Medicine, University of Kufa, Kufa, Iraq. E-mail: drnajahhadi@yahoo.com
Published: May 2023

Atherosclerosis is a common and serious vascular disease that underlies many cardiovascular and cerebrovascular illnesses, including heart attack and stroke. Atherosclerosis-related illnesses have increased in prevalence and now pose a substantial burden on individuals and society. Autophagy (AP) is a process in which cytoplasmic components are engulfed by a double-membrane structure, such as defective organelles and aged, damaged, and flawed proteins. Autophagy is essential for maintaining a proper cellular equilibrium and plays a vital homeostatic role in physiological settings by liberating nutrients from macromolecules and removing undesirable cellular components. This study aimed to investigate the effect of Sitagliptin on the progression of atherosclerosis. Twenty-one male New Zealand White rabbits weighing 2-2.5 kg each were split into three groups: normal control, atherogenic control, and Sitagliptin-treated. The following parameters: serum triglycerides (TG), total cholesterol (TC), LDL, and a tissue autophagy marker (p62) using ELISA, aortic mRNA expression of mTORC1 marker using Real-Time Quantitative PCR(RT-qPCR), and histological inspection of the aorta were assessed. The mRNA expression of mTORC1 and the lipid profile of aortic tissue are considerably elevated in atherogenic diet-fed animals. Histopathological analysis confirmed the presence of a substantial atherosclerotic lesion in the animals fed an atherogenic diet. However, compared to an atherogenic control group, Sitagliptin dramatically reduced lipid profile, P62 aortic level, and mRNA expression of mTORC1. Sitagliptin medication slowed the development of atherosclerosis via increasing autophagy through suppression of the mTORC1 signaling pathway.
Determining the level of stromal and epithelial cells activity in normal and hyperplastic endometrium of late reproductive and perimenopausal women
Authors: Chumak Zinaida Vasilyvna ,   Odessa City Center for Climacteric Problems, Odesa, Ukraine,   Department of Obstetrics and Gynecology, Odesa National Medical University, Odesa, Ukraine, Artyomenko Volodymyr Victorovich ,   Department of Obstetrics and Gynecology, Odesa National Medical University, Odesa, Ukraine,   * Corresponding Author: Volodymyr Victorovich Artyomenko, Department of Obstetrics and Gynecology, Odesa National Medical University, Odesa, Ukraine. E-mail: vartyomenko2017@gmail.com, Shapoval Mykola Vitaliiovich ,   Department of Obstetrics and Gynecology, Odesa National Medical University, Odesa, Ukraine, Mnih Liudmyla Volodymyrivna ,   Department of Obstetrics and Gynecology, Odesa National Medical University, Odesa, Ukraine, Kozhukhar Ganna Volodymyrivna ,   Department of Obstetrics and Gynecology, Odesa National Medical University, Odesa, Ukraine, Derishov Serhii Vasilyovich ,   Department of Obstetrics and Gynecology, Odesa National Medical University, Odesa, Ukraine
Published: May 2023

Hyperplastic processes of the endometrium (HPE) are a group of benign endometrial and stromal cells that have undergone altered growth. This study aimed to investigate the potential role of hypoxia (as indicated by Hif-1α) and apoptosis markers (p53 and BCL-2) in the development of hyperplastic processes of the endometrium (HPE). Results showed that endometrial cells with atypical hyperplasia had increased levels of Hif-1ɑ, which indicates the presence of endometrial hypoxia and may trigger pathological manifestations. Though this result was not statistically significant, it could be the cause of atypia hyperplasia in the late reproductive period (Hif-1ɑ=1.89±0.09 units) and the perimenopausal period (Hif-1ɑ=2.09±0.07 units). Additionally, the study found that p53 markers were elevated in epithelial cells in the late reproductive period, and similar patterns were observed in the perimenopausal period, with the biggest expression in atypical hyperplasia. The study also found that the high expression of BCL-2 indicator (+++) was less common in late reproductive period women with atypia than those without it (χ2=7.2 p=0.01). A similar situation was observed in women in the perimenopausal period (χ2=4.2 p=0.04). These findings suggest that hypoxia may play a role in the development of HPE, as well as changes in apoptotic markers present in the endometrial tissue.