bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPACT OF OPTIMAL ENERGY MIX ON ENVIRONMENTAL QUALITY IN NIGERIA
Authors:   Department of Science Policy and Innovation Studies., Adeteju Omimakinde Elizabeth , Akintayo Omimakinde John ,   Finance and Account Department.National Centre for Technology Management, Obafemi Awolowo University, Ile Ife.
Published: June 2022

The paper aims at giving insight on the energy mix that is suitable for Nigeria environment between 1981 and 2021 using a technique of Fully Modified OLS (FMOLS)The results show that the level of renewable energy consumption that is environmentally friendly is higher than that of non-renewable energy consumption. Also, the two energy consumption components (renewable and non-renewable energy consumptions) had significant effect on environmental quality in Nigeria. It is recommended that greater effort should be made in enhancing environmental quality towards reducing global warming. This is as a result of the fact that renewable energy is portrayed as cleaner energy source, which could be used as alternative to non-renewable energy to curb the problem of environmental hazard arising from carbon emission in the environment.
ASSESSMENT OF ANTHROPOMETRIC FAILURE AMONGST UNDER FIVE CHILDREN IN AN URBANIZED VILLAGE OF DELHI: A CROSS SECTIONAL STUDY
Authors:   Senior Resident, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi., Singh Nidhi , Tiwari Poornima ,   Director Professor, Vardhman Mahavir Medical College & Safdarjung Hospital, Delhi.
Published: June 2022

Background:Childhood malnutrition is a major public health problem be it a developing or developed country. It is a major contributor to the deaths among the under-five group. This highlights the need for an accurate index to measure the burden of malnutrition correctly as traditionally used indices underestimate the burden.A new index, the Composite Index of Anthropometric Failure- CIAF can give a better approximation of the burden of malnutrition amongst under five children. Objective:To assess the nutritional status in terms of Composite Index of Anthropometric Failure (CIAF) amongst under five children in the study population. Methods:A cross-sectional study was conducted to include 260 children under five yearsusing stratified random sampling, in an urbanized village of Delhi from November 2018 to April 2020. Data was collected using pre-designed, semi structured questionnaire. Anthropometric measurements were taken according to World Health Organization (WHO) guidelines. Using WHO 2006 growth charts, Weight-for-Age, Height-for-Age and Weight-for-Height were determined for each child and were used to calculate Composite Index of Anthropometric Failure (CIAF) Prevalence (%).Descriptive statistics and chi square test were applied. Results and Conclusion:Out of the total 260 study participants, only 80 (30.8%) participants had no anthropometric failure i.e., 69.2% had one or more type of anthropometric failure. According to standard anthropometric indices, 39.2% were underweight, 40.8% stunted and 47.3% were wasted. CIAF can act as a single aggregated figure to determine the status of undernourished children in the community.
TRIMALLEOLARFRACTURES :- FRAGMENT SPECIFIC FIXATION AND ITS FUNCTIONAL OUTCOMES
Authors:   Senior Resident, Deptt. Of Orthopaedics, Govt. Medical College, Jammu., Mahajan Rahul , Choudhary Nitin ,   Prof. and HOD, Deptt. Of Orthopaedics, Govt. Medical College, Jammu., Gupta Sanjeev ,   Prof. and HOD, Deptt. Of Orthopaedics, Govt. Medical College, Jammu., Mahajan Neeraj ,   Lecturer, Deptt. Of Orthopaedics, Govt. Medical College, Jammu.
Published: June 2022

Trimalleolar fractures are disabling injuries if not managed properly. Clinical and functional outcomes oftrimalleolar fracture are worse as compared to bimalleolar fractures not involving the posterior malleolus. Various surgical approaches and techniques to reduce and fix these fractures described in the literature.In this case study of 11 patients with trimalleolar fractures, a posterolateral approach was used for fixation of posterior malleolus as well as lateral malleolus in all the cases. A preoperative CT scan was done in all the cases. The Olerud and Molendar scoring system was used to assess the functional outcome.The average age of patients was 52.6 years. The most common mode of sustaining injury was twisting of the ankle joint (n = 7). The average time to union and full weight-bearing was 12 weeks (range 10â€“14 weeks). An excellent functional outcome in 6 patients and a good outcome in 5 patients were obtained at the end of 12 months of follow-up. No significant complications were encountered. The posterolateral approach provides good exposure to fix both posterior and lateral malleolus via single incision. Stable fixation of posterior malleolus plays a vital role in obtaining good clinical and functional outcomes.
Dietary fiber is a reliable and apparent element of treatment for patients with type 2 diabetes mellitus and cardiovascular diseases: an easy solution to a complicated problem
Authors: Demidova T. Yu. , Korotkova T. N. , Kochina A. S.
Published: June 2022

Cardiovascular diseases are a frequent comorbid condition in patients with type 2 diabetes mellitus (t2DM). This problem tends to remain acute because of the progression of t2DM, which increases the chances of cardiovascular events. Medicine today has a range of innovative hypoglycemic drugs, which proved their safety and effectiveness towards diseases of cardiovascular system. However, high cardiovascular mortality demonstrates that the medication is not enough effective. Partly lack of success may be explained by not enough work with unmodified risk factors, such as physical activity, smoking and excessive and wrong nutrition. Studies about dietary fiber (DF) let us discuss their including in the dietary plan of patients with t2DM and cardiovascular diseases. One of the promising DF types is Cyamopsis tetragonoloba extract. It showed its effectiveness concerning carbohydrate metabolism and lipid profile, improving, metabolic features of t2DM patients and lowering the risks of cardiovascular events. What is more, the advantage of Cyamopsis tetragonoloba extract is easy to use and has no side effects.
Antenatal glucocorticosteroids treatment: mechanisms of child healths programming
Authors: Shaitarova A. V. , Suplotova L. A.
Published: June 2022

Synthetic glucocorticoids are widely used in pregnancies at risk of preterm delivery and in pregnant women at risk of having a child with severe 21-hydroxylase deficiency. The positive effects of reducing mortality in preterm and virilisation in girls with congenital adrenal hyperplasia are now unquestionable. The adrenogenital syndrome responding to 21-hydroxylase deficiency is a common, potential fatal disease. Its incidence calculated on the basis of neonatal screening data makes 1 case for 14000 live newborns among the worldwide population, 1 for 9638 – In Russia. DEX passes through the placenta and decreases fetal ACTH production thereby suppressing the fetal production of androgens. The prenatal treatment does not preclude from a life-long treatment in future and it is not prevention of a salt-losing syndrome at the postnatal period, and dexamethasone safety in relation to cognitive development of children prenatally treated with dexamethasone is still up for debate. Adding to the concern is the fact that the doses of DEX that the fetus is exposed to are estimated to be 60 times the normal fetal cortisol level. The glucocorticoid and the mineralocorticoid receptors are highly expressed in the hippocampus, amygdala, and prefrontal cortex. These areas, important for executive functioning, emotional regulation, and memory, are vulnerable to high doses of GCs. Most experimental data from animal have shown that prenatal exposure to synthetic glucocorticoids programs the foetal HPA and may lead to altered susceptibility to metabolic and cardiovascular disease i.e. metabolic syndrome, high blood pressure. Prenatal glucocorticoid exposure also leads to modification of HPAassociated behaviours and cognition.
Study of equivalence and comparable immunogenicity of biosimilar insulin aspart in comparison with the registered analogue
Authors: Karonova Т. L. , Mayorov A. Y.
Published: June 2022

The increase in the prevalence of diabetes mellitus has accelerated significantly in recent years. The situation has been greatly complicated by the COVID-19 pandemic. On the one hand, diabetes mellitus is a risk factor for a severe course of infection, and on the other hand, COVID-19 increases the risk of developing diabetes mellitus. There remain other negative factors that reduce the effectiveness of measures taken to combat the disease: lack of public awareness about diabetes, its effects and preventive measures, which contributes to low vigilance against the disease and neglect of active prevention of diabetes in order to eliminate correctable risk factors. In turn, this leads to an increase in the number of people with insulin resistance and prediabetes. Another important aspect is the lack of effective continuous glycemic control in many patients with diabetes, which increases the risk of complications and disability later in life. The availability of drugs for treatment, especially insulin, is also a problem that can be solved by developing and introducing biosimilars of original insulin drugs on the pharmaceutical market. An important condition for the possibility of transferring patients to more affordable insulin biosimilars is comparability with the reference insulin at all stages of preclinical and clinical trials, proven in accordance with current ESE recommendations. These include the use of the hyperinsulinemic euglycemic clamp method to evaluate pharmacokinetics and pharmacodynamics, as well as immunogenicity studies.
Experience with olaparib in a patient with luminal HER2-positive metastatic breast cancer
Authors: Bolotina L. V. , Kornietskaya A. L. , Kachmazov A. A. , Prizova N. S. , Paichadze A. A. , Ustinova T. V. , Deshkina T. I. , Evdokimova S. F.
Published: June 2022

Hereditary breast cancer (BC) accounts for about 5-10% of cases. BRCA-associated tumors have been identified as a separate group of malignant neoplasms with distinctive clinical manifestations and specific treatment features. Understanding of biological mechanisms leading to cancer in BRCA1/2 mutation carriers and discovery of potential molecular targets, such as poly (ADP-ribose) polymerase (PARP), involved in base excision repair mechanisms, led to the development of a new class of targeted drugs belonging to the PARP inhibitors group. PARP inhibition leads to the preservation of single-stranded DNA breaks, the arrest of the replication fork, and the realization of the “synthetic lethality” phenomenon due to the inability to repair double-stranded DNA breaks by homologous recombination in cells with mutations in the BRCA1/2 genes. Two randomized trials OlympiAD and EMBRACA evaluated and proved the effectiveness of PARP inhibitors in patients with metastatic BRCA-mutated HER2-negative breast cancer in comparison with standard chemotherapy. At the same time, data on the potential use of PARP inhibitors for the treatment of BRCA-mutated HER2-positive breast cancer patients are extremely limited. This article presents a clinical example of the use of olaparib in a patient with BRCA-mutated HER2-positive metastatic breast cancer.
Evaluation of Associated Structural and Chromosomal Abnormalities in Patients with Fetal Cerebral Ventriculomegaly Detected in Ultrasonographic Imaging
Authors: Cagliyan Erkan , Ozmen Samican , Saridas Demir Sureyya , Aydin Ceren , Bilen Egehan , Guleryuz Handan , Yasar Elif , Ercal Derya , Bora Elcin , Cankaya Tufan
Published: June 2022

OBJECTIVE: Fetal cerebral ventriculomegaly is defined as enlarged cerebral lateral ventricles. The etiology of fetal cerebral ventriculomegaly is multifactorial. Aneuploidy in ventriculomegaly is detected especially in moderate and severe ventriculomegaly accompanied by structural anomalies. This study aims to evaluate patients with fetal cerebral ventriculomegaly for associated structural and genetic abnormalities and their obstetric and neonatal outcomes.
STUDY DESIGN: This retrospective cohort study was conducted at Dokuz Eylul University Faculty of Medicine, Obstetrics and Gynecology Department between January 2009 and December 2019. Eighty-seven cases were included in the study and were evaluated for associated structural abnormalities. The results of genetic diagnostic tests were evaluated retrospectively. Postpartum information of the cases was obtained from the hospital records and neurodevelopmental development of the newborns was recorded.
RESULTS: Patients were classified as mild, moderate, and severe ventriculomegaly. Concomitant structural abnormalities were observed in 64% of the patients. Corpus callosum agenesis was the most common abnormality. The incidence of accompanying anomalies in severe ventriculomegaly was found to be significantly higher. Invasive prenatal tests were performed on 27 patients and one of them had a chromosomal abnormality. No significant correlation was observed between the incidence of postpartum neurodevelopmental disorders and the degrees of ventriculomegaly.
CONCLUSIONS: Fetal cerebral ventriculomegaly is a dynamic process. The etiology is multifactorial and abnormalities can be detected during follow-up. All patients should be evaluated carefully for associated abnormalities. The cases should also be evaluated for neurodevelopmental outcomes after birth. All diagnosis, follow-up, and treatment options should be handled with a multidisciplinary approach.
Groundwater levels hierarchical clustering and regional groundwater drought assessment in heavily drafted aquifers
Authors: Yin Jina , Medellín-Azuara Josué , Escriva-Bou Alvar
Published: June 2022

Groundwater overexploitation along with decreasing precipitation exacerbates groundwater level decline and causes groundwater drought. Efficient assessment of the drought is critical to water management, especially in drought-prone agriculture regions. It remains challenging to characterize groundwater drought quantitatively due to the difficulty in obtaining groundwater observation data and the complexity of groundwater flow systems. To this end, agglomerative hierarchical cluster analysis was performed on long-term groundwater levels to classify wells in the San Joaquin River Basin, California. A Modified Mann–Kendall (MMK) test was undertaken to detect seasonal groundwater level trends from 1980 to 2019, and the magnitude was calculated using Sen's slope estimator. A nonparametric Standardized Groundwater level Index (SGI) was used to quantify the characteristics of groundwater drought. Results show that long-term (40-year) temporal patterns in groundwater levels varied significantly over the San Joaquin River Basin. Significantly decreasing trends were observed among more than 34.6% of wells, with an average decline of 0.69 m/year. Wells suffered frequent and severe groundwater droughts in the last decade, which were mainly driven by heavy groundwater exploitation. Findings provide useful information about the long-term behavior of regional groundwater levels, which in turn help stakeholders monitor droughts and adapt groundwater management strategies.
A comprehensive framework model for the trend, period and evaluation of the precipitation enhancement effect: TPEM
Authors: Liu Chengshuai , Sun Yue , Yu Qiying , Niu Chaojie , Soomro Shan-e-hyder , Hu Caihong
Published: June 2022

In this study, a framework model (TPEM) for evaluating the temporal and spatial variation of urban precipitation is established. TPEM includes seven calculation methods at the same time. Taking the annual precipitation and flood season precipitation data of eight meteorological stations in Zhengzhou, China, from 1960 to 2020 as an example, the trend and period of rain island effect in Zhengzhou are analyzed from the annual and flood season rainfall scale, and the distance method is introduced to quantitatively evaluate the rain island effect. The results show that the rain island effect in the central urban area of Zhengzhou has a sudden increase trend in 1997 and 2004 respectively, and the increasing trend of rain island effect on the scale of annual and flood season rainfall lasts for four and ten years respectively. At the same time, it has fluctuation periods of 8–10a, 16–18a, 3–5a, 17–20a, 5–7a, and 2–3a respectively. The rain island effect in Zhengzhou is concentrated in the flood season. The research can provide a scientific basis for cities to deal with the rain island effect in the future.
Survival-related Factors in HIV/AIDS Patients: A Retrospective Cohort
Study from 2011 to 2019 in Kermanshah, Iran
Authors: Ghadiri Keyghobad , Lorestani Roya Chegene , Kazemisafa Narges , Rostamian Mosayeb , Akya Alisha , Rezaeian Shahab , Bashiri Homayoon , Jasemi Seyed Vahid
Published: June 2022

Introduction:

Accurate evaluation of the survival rate among HIV-positive populations is pivotal for HIV management.

Objective:

This study aimed to investigate the survival rate and potential survival-related factors in HIV/AIDS patients from 2011 to 2019 in the city of Kermanshah in the west of Iran.

Method:

In this study, 915 HIV-positive patients registered by the Kermanshah Behavioral diseases counseling center, were surveyed from 2011 to 2019. By reading the patients' files, the proper data related to the survival factors were extracted and statistically analyzed.

Results:

Of 915 patients, 220 (24%) died. The one-year, five-year, and ten-year survival rates were 84%, 72%, and 62%, respectively. There was a significant relationship between the survival rate and many other parameters, including treatment variables, CD4+ T cell count, the way of HIV transmission, level of education, gender, and marital status. Over time, timely initiation of treatment has increased. The data also showed that HIV transmission through drug injection has decreased, while the sexual transmission of HIV has increased.

Conclusions:

The results showed that in recent years, due to the appropriate treatment, the survival rate of HIV patients has increased. The highest risk factor of death was for people with low CD4+ T cell count, lack of antiretroviral therapy, low level of education, male gender, and people who inject drugs. These people need more attention to get tested for HIV- related indexes and to receive proper treatment.
Serum Level of Soluble Human Leukocyte Antigen G in Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis
Authors: khodashahi Mandana , Rezaieyazdi Zahra , Rezaeian Amin
Published: June 2022

Background:

This study aimed to evaluate the serum level of human leukocyte antigen
G [HLA-G] in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)
compared to healthy controls; moreover, it attempted to assess its relationship with SLE and RA
disease activity indices.

Methods:

This descriptive study was conducted on 31 SLE patients (17 cases with a recent diagnosis
and 14 cases with a previous diagnosis), 21 RA patients (7 cases with a recent diagnosis and 14
cases with a previous diagnosis), and 18 healthy controls who visited Ghaem Hospital affiliated to
Mashhad University of Medical Sciences, Mahhad, Iran. SLE and RA activity indices were measured
and recorded. Furthemore, soluble isoforms, including shed HLA-G1 and HLA-G5, were
measured in serum samples via the ELISA method.

Results:

A comparison of the five groups showed no significant differences in the serum level of
sHLA-G. However, sHLA-G serum level was significantly higher in SLE and RA patients compared
to healthy controls (P<0.05). sHLA-G level showed no correlation with disease duration and
activity in SLE and RA patients (P>0.05). However, a strong positive correlation was observed between
the serum level of sHLA-G and 24-h urine protein in the previously diagnosed SLE group
(r=0.83, P=0.01).

Conclusion:

It seems that the serum level of sHLA-G is higher in RA and SLE patients compared
to healthy controls. Furthermore, a strong correlation was found between sHLA-G serum levels and
24-h urine protein in cases with a previous diagnosis of SLE.
Emerging Role of miRNAs in the Pathogenesis of Periodontitis
Authors: Taheri Mohammad , Khoshbakht Tayyebeh , Hussen Bashdar Mahmud , Abdullah Sara Tharwat , Ghafouri-Fard Soudeh , Sayad Arezou
Published: June 2022

MicroRNAs (miRNAs) have been found to participate in the pathogenesis of several
immune-related conditions through the modulation of the expression of cytokine coding genes and
other molecules that affect the activity of the immune system. Periodontitis is an example of these
conditions associated with the dysregulation of several miRNAs. Several miRNAs such as let-7
family, miR-125, miR-378, miR-543, miR-302, miR-214, miR-200, miR-146, miR-142, miR-30
and miR-21 have been shown to be dysregulated in patients with periodontitis. miR-146 is the most
assessed miRNA in these patients, which is up-regulated in most studies in patients with periodontitis.
In the present review, we describe the impact of miRNAs dysregulation on the pathoetiology of
periodontitis.
SpBLRSR: Schatten p-norm Constrained Bounded Low-rank Subspace
Recovery for Predicting N7-methylguanosine (m7G)-disease Associations
Authors: Ma Jiani , Zhang Lin , Chen Xiangzhi , Liu Hui
Published: June 2022

Background:

As an essential positively charged RNA modification, N7-methylguanosine (m7G) has been reported to be associated with multiple diseases including cancers. While transcriptome-wide m7G sites have been identified by high-throughput sequencing approaches, the disease-associated m7G sites are still largely unknown. Therefore, computational methods are urgently needed to predict potential m7G-disease associations, which is crucial for understanding the biosynthetic pathways of tumorigenesis at the epi-transcriptome layer.

Objective:

We hope to develop an effective computational method that can accurately predict the associations between m7G sites and diseases, and then to prioritizing candidate m7G sites for novel diseases.

Method:

In this article, we proposed a Schatten p-norm constrained bounded low-rank subspace recovery (SpBLRSR) method for m7G-disease association prediction. An m7G-disease block matrix was built to alleviate the sparseness during the association pattern discovery process. By incorporating the low-rank representation (LRR) model and sparse subspace clustering (SSC) model, SpBLRSR was designed to capture both the global and local structures of the association pattern.

Results:

Compared with the benchmark methods, SpBLRSR achieved the
best performance in predicting associations between m7G sites and disease, and in prioritizing m7G sites for novel diseases. Then the robustness of Schatten p-norm in our method was further validated via a noise contamination experiment. Finally, case study of breast cancer was performed to elucidate the biological meaning of our method.

Conclusion:

SpBLRSR exploits the disease pathogenesis at the epitranscriptome layer by predicting potential m7A sites for disease.
Impact of COVID-19 on Brain and Psychological Health, its Possible Mechanisms, and Coping Strategies
Authors: Simnani Faizan Zarreen , Singh Dibyangshee , Choudhury Anmol , Akhtar Ansab
Published: June 2022

Abstracts:

COVID-19 pandemic has been depicted to possess a robust association with psychological disorders. SARS-CoV-2 is the most recent virus of the coronavirus family and has the potential to bind the angiotensin-converting enzyme (ACE) receptor. The receptor is mainly present peripherally and to some extent in the brain. Different psychological and neurodegenerative disorders can arise due to the peripheral origin of destruction. These triggers could be inflammatory pathways releasing pro-inflammatory cytokines reaching the brain and causing neuroinflammation. In continuation with traditional viruses, SARS-CoV-2 too might lead to brain diseases like meningitis, encephalitis, etc. Besides, several peripheral hormonal changes like cortisol can influence neurochemical alterations, thereby inflicting mood-related activities and psychological phenomena. In this regard, health care workers, frontline line warriors and relatives of COVID-19 patients can be the secondary victims; however, patients with COVID-19 remain the primary ones prone to neurological health problems. Several strategies like socialization, engagement, physical activity, etc., are well-opted measures to get relief from and check psychiatric disturbances. The worth of this review can be attributed to the understanding of brain-related mechanisms of COVID-19 in the context of its mechanism of action to create the pathology pertaining to brain disorder, precisely psychological devastation. Likewise, its epidemiological relevance has concisely been mentioned. Furthermore, different categories and classes of people prone to psychological deterioration are briefly elaborated on. Lastly, some coping strategies and approaches have been discussed to minimize or combat mental health problems.
The TP53 Gene and COVID-19 Virus: A Correlation Analysis
Authors: Anand C. Lakshmi , Namboori P.K. Krishnan
Published: June 2022

Aim:

This study aimed to discover the most effective anti-cancer medicine for cancer patients
infected with SARS-CoV-2.

Background:

The correlation between TP53 and SARS-CoV-2 was examined using biomolecular
networking analysis.

Objective:

Cancer patients with TP53 gene mutations are more likely to be infected with the SARSCoV-
2 virus since it is the most frequently mutated tumor suppressor gene in human cancer. The main
goal of this study is to discover the most effective and efficient anti-cancer therapy for patients with
SARS-CoV-2 infection.

Materials and Methods:

Topp gene analysis was used to prioritize candidate genes based on molecular
function, biological process, and pathway analysis. Biomolecular networking was carried out using
Cytoscape 2.8.2. The protein-protein interaction network was used to identify the functionally associated
proteins. The protein-drug interaction network was used to observe the molecular therapeutic efficiency
of drugs. The network was further analyzed using CytoHubba to find the hub nodes. The molecular
docking was used to study the protein-ligand interaction, and the protein-ligand complex was
further evaluated through molecular dynamic simulation to determine its stability.

Results:

Functionally relevant genes were prioritized through Toppgene analysis. Using Cytohabba, it
was found that the genes UBE2N, BRCA1, BARD1, TP53, and DPP4 had a high degree and centrality
score. The drugs 5-fluorouracil, Methotrexate, Temozolomide, Favipiravir, and Levofloxacin have a
substantial association with the hub protein, according to protein-drug interaction analysis. Finally, a
docking study revealed that 5-fluorouracil has the highest connection value and stability compared to
Methotrexate, Favipiravir, and Levofloxacin.

Conclusion:

The biomolecular networking study was used to discover the link between TP53 and SARSCoV-
2, and it was found that 5-fluorouracil had a higher affinity for binding to TP53 and its related
genes, such as UBE2N, BRCA1, RARD1, and SARS-CoV-2 specific DPP4. For cancer patients with
TP53 gene mutations and Covid-19 infection, this treatment is determined to be the most effective.
Effect of Curcumin on Oxidative Stress, Inflammatory Response and
Kidney Biochemical Parameters Among Kidney Disease Patients: A
Systematic Review
Authors: Emami Elham , Talebi-Boroujeni Parham , Sherwin Catherine M.T. , Heidari-Soureshjani Saeid , Mohammadi Somayeh
Published: June 2022

Background:

Chronic kidney disease (CKD) and end-stage renal diseases have high
global morbidity and mortality.

Objective:

We aimed to investigate the antioxidant and anti-inflammatory properties of curcumin
and its impact on kidney biochemical parameters associated with kidney disease among CKD and
hemodialysis (HD) patients.

Methods:

The intended keywords were used in the literature search. Clinical trial studies from the
beginning to December 25th, 2021, indexed in the Institute for Scientific Information (ISI),
Scopus, and PubMed databases, were included in the review. Records with no accessible full texts,
non-English language articles, and studies that were not related to the study aim were excluded.
The agreement for exclusion required all authors to concur. Finally, after reviewing all available
literature, 27 articles were included in this systematic review.

Results:

Curcumin supplementation increased antioxidant capacity by improving catalase (CAT)
activity, free radical scavenging activity, and nuclear factor erythroid 2–related factor 2 (Nrf2). It
also reduced hs-CRP, IL-6, and TNF-a levels in patients with CKD and HD patients. Different
results were reported regarding the effect of curcumin on kidney-related biochemical parameters.
But mostly, the results showed that no significant changes were seen in glomerular filtration
(GFR), albumin (Alb), serum creatinine (sCr), proteinuria (PRO), and blood urea nitrogen (BUN)
in these patients.

Conclusion:

Although it seems curcumin improved antioxidant capacity and decreased inflammatory
cytokines in CKD and HD patients, it did not affect renal biochemical parameters. More clinical
studies with larger sample sizes appear to be needed.
Potential Plant Secondary Metabolites for the Prevention of Skin Cancers
and their Mechanism: A Review
Authors: Kadian Jai Parkash , Kaushik Madan Lal , Chauhan Bhupendra , Singh Aniruddh Dev
Published: June 2022

Skin carcinoma is the most common malignancy, including malignant melanoma and
non-malignant melanoma throughout the world, and in the last three decades, its incidences have
been increasing drastically. High cost, severe side effects and development of resistance from conventional
chemotherapy have decreased its acceptability and increased the urge for the search for
alternate options. Therefore, plant derived phytochemicals have come up with cost effectiveness,
ease of availability and promising potential for skin related cancers. In spite of the lack of clinical
data involving humans to support the positive effects of phytochemicals on different types of skin
cancers, topical application of these plant derived anticancer phytochemicals is extremely promising.
Many mechanisms and pathways underlie the antitumor activity of plant-derived phytochemicals
, such as loss of mitochondrial membrane potential, the release of cytochrome-c, suppression of
antiapoptotic proteins and induction of proapoptotic proteins, activation of caspases, Fas, FADD and
p53 signaling pathway, inhibition of Akt signaling pathway, phosphorylation of ERK, P13K, Raf,
survivin gene, STAT 3 and NF-kB. The use of cell line models in the in vitro study of skin cancer
offers the opportunity to identify the mechanisms of action of plant derived phytochemicals against
various types of skin cancer. As such, this article aims at providing a comprehensive review of plant
extracts and phytochemicals, which have been reported to exhibit promising anti-carcinogenic properties
in animal models and against various skin cancer cell lines.
Focus, vertrouwen, veerkracht: en andere mentale aspecten van sport en presteren
Authors: van Yperen Nico
Published: June 2022

In dit boek wordt wetenschappelijke kennis omtrent de mentale aspecten van sport en presteren toegankelijk gemaakt. Niet alleen voor sporters, coaches, trainers en andere sportgeïnteresseerden, maar ook voor lezers die niet veel met sport hebben, maar wel willen leren van de (top)sport. Immers, ook op het werk, op school, in het theater, in de kunst, wetenschap, politiek en zakenwereld wordt vaak prestatiedruk ervaren. Dus ook in die domeinen spelen factoren als focus, vertrouwen, veerkracht, passie, plezier, perfectionisme, doelen, motivatie en teamgeest een belangrijke rol. Meer inzicht in deze mentale factoren, en vooral ook de bijbehorende training en ervaring, zullen helpen mentaal sterker te worden. Wie wil dat niet?
Ritual Counsellors’ Value Tensions in Profiling. A Pilot Study Using Organizational Constellations
Authors: Mulder André , Stoof Angela
Published: June 2022

Ritual counsellors are self-employed entrepreneurs that mainly guide funeral rites. Literature suggests that ritual counsellors may experience tensions between values in profiling themselves to the media and funeral market. Assigned by the Dutch professional organization for ritual counsellors (LBVR), a qualitative case study was designed. Using the innovative method of organizational constellations, we investigate underlying tensions in a profiling situation. 10 Dutch ritual counsellors participated. Results indicate that they experience a tension between ‘money’ and ‘being there for other people’. Normatively, ‘money’ is valued less than ‘being there’. Ritual counsellors render multiple, sometimes contradicting meanings of ‘money’ that include mental, normative and felt elements. The tension is on a deeper level related to ‘acknowledgment’.
Time to Say Goodbye? A Study on Music, Ritual and Death in the Netherlands
Authors: Bruin-Mollenhorst Janieke
Published: June 2022

Summary of the dissertation "Time to Say Goodbye? A Study on Music, Ritual and Death in the Netherlands".
Comfort in Luther and Bach. A Study of the Comforting Value of Martin Luther’s Church Songs and Interpretation of Comfort in the Choral Cantatas of Johann Sebastian Bach
Authors: Vroegindeweij Lydia
Published: June 2022

Summary of the dissertation "Comfort in Luther and Bach. A Study of the Comforting Value of Martin Luther’s Church Songs and Interpretation of Comfort in the Choral Cantatas of Johann Sebastian Bach".
Pengembangan Modul Pembelajaran Penggunaan ArcGIS Online untuk Pembuatan Peta Penyebaran Gedung: Studi Kasus pada Peta Penyebaran SMK Kompetensi Keahlian DPIB di Daerah Istimewa Yogyakarta
Authors: Sukmantari Hanna Nursanti , Marsudi Ilham , Raharjo Nuryadin Eko
Published: June 2022

ABSTRACTThe purpose of this study was to develop a learning module for the use of ArcGIS Online in making the distribution map of the SMK DPIB expertise program in DIY in the Geomatics Practicum II course in the Department of Civil Engineering and Planning UNY. This research is included in research and development or Research and Development (RD), the 4D (four-D) method by Thiagarajan. The data collection technique spreads questionnaires to respondents. Qualitative descriptive technique as a data analysis technique. The results of this study are: (1) The development of learning media through the 4D stage. The defining stage (Define) is to obtain the needs in using ArcGIS Online., The selected media design stage is the learning module, the development stage (Develop) stage is validated by material experts, and media experts then a feasibility test is carried out on the user ,, and the dissemination stage (Disseminate), the dissemination stage is carried out by spreading the media that has been developed. The learning media developed is a learning module. The feasibility of the learning module is based on the assessment of the material expert, namely 3.93 with the "Feasible" category, media experts of 4.77 with the "Very Appropriate" category, and the user feasibility test of 4.23 with the "Very Appropriate" category.Keywords: ArcGIS Online, Learning Module, DevelopmentABSTRAKTujuan dari penelitian ini adalah untuk mengembangkan modul pembelajaran penggunaan ArcGIS Online dalam pembuatan peta sebaran SMK program keahlian DPIB di DIY pada mata kuliah Praktikum Geomatika II di Jurusan Pendidikan Teknik Sipil dan Perencanaan UNY. Penelitian ini termasuk ke dalam penelitian dan pengembangan atau Research and Development (RD), menggunakan metode 4D (four-D) oleh Thiagarajan. Teknik pengumpulan data menggunakan menyebar angket kepada responden. Teknik yang digunakan berupa deskriptif kualitatif sebagai teknik analisis data. Hasil penelitian mendapatkan hasil yaitu Pengembangan media pembelajaran melalui tahap 4D. Tahap pendefinisian (Define) adalah untuk memperoleh kebutuhan penggunaan ArcGIS Online, tahap perancangan (Design) media yang dipilih yaitu modul pembelajaran, tahap pengembangan (Develop) tahap ini dilakukan validasi ahli materi, dan ahli media kemudian dilakukan uji kelayakan kepada pengguna, dan tahap penyebaran (Disseminate), tahap penyebaran dilakukan dengan menyebarkan media yang telah dikembangkan. Media pembelajaran yang dikembangkan adalah modul pembelajaran. Kelayakan modul pembelajaran berdasarkan penilaian dari ahli materi, yaitu 3,93 dengan kategori “Layak”, untuk ahli media sebesar 4,77 dengan kategori “Sangat Layak”, sdangkan uji kelayakan pengguna sebesar 4,23 dengan kategori “Sangat Layak”.
Pengembangan Modul Pembelajaran Mata Kuliah Praktik Kerja Plambing dan Sanitasi di Prodi Pendidikan Teknik Sipil dan Perencanaan FT UNY
Authors: Syamsudin Rudi Nur , Hidayat Nur , Prihadi Wisnu Rachmad , Malik Abdul , Wibowo Dian Eksana
Published: June 2022

ABSTRACTThis study aims to: (1) understand and carry out the stages of preparing the learning module for the plumbing and sanitation work practice course; (2) determine the feasibility level of the learning module for the plumbing and sanitation work practice course. This study uses a 4-D model research and development approach which consists of four stages, namely: defining, planning, developing, and disseminating. The results of the module development research are: (1) define, there is no learning module for plumbing and sanitation work practice courses, (2) design, there are sixteen material discussions that are adjusted based on the curriculum and learning outcomes and are composed of learning objectives, material descriptions, summaries. , independent assignments,worksheets; (3) development, the assessment of the material obtained a score of 3.45 in the very appropriate category, the media assessment obtained a score of 3.37 in the appropriate category, and the assessment of the lecturer in charge of the subject received a score of 3.11 in the appropriate category; (4) dissemination, submission of modules to lecturers who are in charge of plumbing and sanitation work practices in the form of hardcopy and softcopy.Keywords: Module, Plumbing, Sanitation, Model 4-DABSTRAKPenelitian ini bertujuan untuk: (1) memahami dan melaksanakan cara penyusunan modul pembelajaran mata kuliah praktek kerja plambing dan sanitasi; (2) mengetahui kelayakan modul pembelajaran mata kuliah praktek kerja plambing dan sanitasi. Metodologi dalam penelitian ini menggunakan pendekatan penelitian dan pengembangan model 4-D yang terdiri dari empat tahap, yaitu: define (pendefinisian), design (perencanaan), develop (pengembangan), disseminate (penyebarluasan). Hasil penelitian pengembangan modul ini adalah: (1) define, belum tersedianya modul pembelajaran pembelajaran mata kuliah praktek kerja plambing dan sanitasi, (2) design, terdapat empat pembahasan materi, modul tersusun dari tujuan pembelajaran, uraian materi, rangkuman, dan soal latihan; (3) development, saran yang didapat adalah (detail materi dilengkapi, komposisi gambar dengan keterangan, dan ilustrasi menggunakan warna kontras dengan latar). Penilaian pada materi memperoleh skor 3,50 kategori sangat layak, penilaian media memperoleh skor 3,02 kategori layak, dan penilaian guru memperoleh skor 3,59 kategori sangat layak; (4) disseminate, penyerahan modul kepada dosen pengampu mata kuliah praktek kerja plambing dan sanitasi berupa softfile dan hardfile.
Building a proper churn prediction model for Vietnam's mobile banking service
Authors:   Faculty of Banking and Finance, Foreign Trade University, Hanoi, Vietnam, Thanh Nguyen Thi Ha , Vy Nguyen Thao ,   MB Shinsei Finance Limited Liability Company, Hanoi, Vietnam
Published: June 2022

This study aims to build a model predicting the churn rate of customers using mobile banking services in Vietnam by applying data mining techniques. Customer churn is an issue that any service provider must pay attention to because it is decisive to the development of the business. The competition between banks is getting tougher, hence customer churn prediction has become of great concern to banking service companies. It is necessary for banks to collect colossal data and establish a valued model for classifying types of customers. In this study, three supervised statistical learning methods which are KNN, Random Forest, and Gradient Boosting are applied to the churn prediction model using the data source of VIB’s customers. In addition to selecting models belonging to the group of weak single learners such as Neural Networks, Naïve Bayes Classifier, and K-nearest Neighbor..., this paper utilizes Random Forest and Gradient Boosting which are assessed as better models because they can combine weak learners for improving model efficiency and capable of classification. The results exhibited that Gradient Boosting is the best performance in the three above classifiers with a 79.71% of accuracy rate, and 86.23% of ROC (Receiver Operating Characteristic) curve graph. Moreover, the decision tree algorithm generates readable rules for churner and non-churner classification which are potentially helpful to managers. Finally, this study suggests a proper model that can be used to forecast churners of mobile banking services in Vietnam.
Worldwide Presence of National Anesthesia Societies on Four Major Social Networks in 2021: Observational Case Study
Authors: Clavier Thomas , Occhiali Emilie , Guenet Claire , Vannier Naurine , Hache Camille , Compere Vincent , Selim Jean , Besnier Emmanuel
Published: June 2022

Background

Although the presence of medical societies on social networks (SNs) could be interesting for disseminating professional information, there is no study investigating their presence on SNs.

Objective

The aim of this viewpoint is to describe the worldwide presence and activity of national anesthesia societies on SNs.

Methods

This observational study assessed the active presence (≥1 post in the year preceding the collection date) of the World Federation of Societies of Anesthesiologists member societies on the SNs Twitter, Facebook, Instagram, and YouTube. We collected data concerning each anesthesia society on the World Federation of Societies of Anesthesiologists website.

Results

Among the 136 societies, 66 (48.5%) had an active presence on at least one SN. The most used SN was Facebook (n=60, 44.1%), followed by Twitter (n=37, 27.2%), YouTube (n=26, 19.1%), and Instagram (n=16, 11.8%). The SN with the largest number of followers was Facebook for 52 (78.8%) societies and Twitter for 12 (18.2%) societies. The number of followers was 361 (IQR 75-1806) on Twitter, 2494 (IQR 1049-5369) on Facebook, 1400 (IQR 303-3058) on Instagram, and 214 (IQR 33-955) on YouTube. There was a strong correlation between the number of posts and the number of followers on Twitter (r=0.95, 95% CI 0.91-0.97; P<.001), Instagram (r=0.83, 95% CI 0.58-0.94; P<.001), and YouTube (r=0.69, 95% CI 0.42-0.85; P<.001). According to the density of anesthetists in the country, there was no difference between societies with and without active SN accounts.

Conclusions

Less than half of national anesthesia societies have at least one active account on SNs. Twitter and Facebook are the most used SNs.
Exploring the Association of Cancer and Depression in Electronic Health Records: Combining Encoded Diagnosis and Mining Free-Text Clinical Notes
Authors: Leis Angela , Casadevall David , Albanell Joan , Posso Margarita , Macià Francesc , Castells Xavier , Ramírez-Anguita Juan Manuel , Martínez Roldán Jordi , Furlong Laura I , Sanz Ferran , Ronzano Francesco , Mayer Miguel A
Published: June 2022

Background

A cancer diagnosis is a source of psychological and emotional stress, which are often maintained for sustained periods of time that may lead to depressive disorders. Depression is one of the most common psychological conditions in patients with cancer. According to the Global Cancer Observatory, breast and colorectal cancers are the most prevalent cancers in both sexes and across all age groups in Spain.

Objective

This study aimed to compare the prevalence of depression in patients before and after the diagnosis of breast or colorectal cancer, as well as to assess the usefulness of the analysis of free-text clinical notes in 2 languages (Spanish or Catalan) for detecting depression in combination with encoded diagnoses.

Methods

We carried out an analysis of the electronic health records from a general hospital by considering the different sources of clinical information related to depression in patients with breast and colorectal cancer. This analysis included ICD-9-CM (International Classification of Diseases, Ninth Revision, Clinical Modification) diagnosis codes and unstructured information extracted by mining free-text clinical notes via natural language processing tools based on Systematized Nomenclature of Medicine Clinical Terms that mentions symptoms and drugs used for the treatment of depression.

Results

We observed that the percentage of patients diagnosed with depressive disorders significantly increased after cancer diagnosis in the 2 types of cancer considered—breast and colorectal cancers. We managed to identify a higher number of patients with depression by mining free-text clinical notes than the group selected exclusively on ICD-9-CM codes, increasing the number of patients diagnosed with depression by 34.8% (441/1269). In addition, the number of patients with depression who received chemotherapy was higher than those who did not receive this treatment, with significant differences (P<.001).

Conclusions

This study provides new clinical evidence of the depression-cancer comorbidity and supports the use of natural language processing for extracting and analyzing free-text clinical notes from electronic health records, contributing to the identification of additional clinical data that complements those provided by coded data to improve the management of these patients.
Understanding How and by Whom COVID-19 Misinformation is Spread on Social Media: Coding and Network Analyses (Preprint)
Authors: Zhao Yuehua , Zhu Sicheng , Wan Qiang , Li Tianyi , Zou Chun , Wang Hao , Deng Sanhong
Published: June 2022

BACKGROUND

During global health crises such as the COVID-19 pandemic, rapid spread of misinformation on social media has occurred. The misinformation associated with COVID-19 has been analyzed, but little attention has been paid to developing a comprehensive analytical framework to study its spread on social media.

OBJECTIVE

We propose an elaboration likelihood model–based theoretical model to understand the persuasion process of COVID-19–related misinformation on social media.

METHODS

The proposed model incorporates the central route feature (content feature) and peripheral features (including creator authority, social proof, and emotion). The central-level COVID-19–related misinformation feature includes five topics: medical information, social issues and people’s livelihoods, government response, epidemic spread, and international issues. First, we created a data set of COVID-19 pandemic–related misinformation based on fact-checking sources and a data set of posts that contained this misinformation on real-world social media. Based on the collected posts, we analyzed the dissemination patterns.

RESULTS

Our data set included 11,450 misinformation posts, with medical misinformation as the largest category (n=5359, 46.80%). Moreover, the results suggest that both the least (4660/11,301, 41.24%) and most (2320/11,301, 20.53%) active users are prone to sharing misinformation. Further, posts related to international topics that have the greatest chance of producing a profound and lasting impact on social media exhibited the highest distribution depth (maximum depth=14) and width (maximum width=2355). Additionally, 97.00% (2364/2437) of the spread was characterized by radiation dissemination.

CONCLUSIONS

Our proposed model and findings could help to combat the spread of misinformation by detecting suspicious users and identifying propagation characteristics.