bluuebunny/crossref_metadata_2025 huggingface dataset:
Bersinar di Era Digital: Strategi Manajemen Berbahasa Indonesia untuk Meningkatkan Minat Generasi Milenial dan Gen-Z
Authors: Anisa Resha Yanur , Rahmi Aisyah Alya , Haniyah Siti Muanah , Agustiani Fauziah Nur , Pajriati Nur , Rizkyanfi Mochamad Whilky
Published: May 2024

Technology has an important role in today's digital era. The existence of the digital era increases communication skills, it is important for Indonesian management to continue to innovate and adapt the use of technology in order to effectively attract and influence millennials and gen-Z who are active in digital platforms. The method used was qualitative by conducting interviews with three banking employees in the city of Bandung. The collected data are analyzed, reduced, presented and conclusions drawn. The results showed that there is a link between the success of the company and effective Indonesian-language management. Understanding consumers, especially to attract millennials and gen-Z, can be done by improving services by utilizing digitalization. The service digitalization strategy was developed to facilitate consumers and improve the company in market competition. The use of EYD-compliant Indonesian makes it easier for consumers to understand the service and avoid misunderstandings. Good service, structured Indonesian-language management shows a professional company image and is trusted by consumers. Research is expected to increase the use of good and correct Indonesian in a company when providing information to consumers and increase the attractiveness and involvement of millennials and gen-Z as consumers
Fungsi Manajamen dalam Al-Quran dan Hadist: Studi Literatur
Authors: Basri Henny Hamdani , Heliwasnimar Heliwasnimar , Satriadi Inong
Published: May 2024

Management is an activity that starts from planning, organizing, mobilizing, supervising to coordinate existing resources to achieve common goals in an organization. In the Islamic view, the function of education management reviewed in the Qur'an has several discussions including: (1) planning, (2) organizing; (3) actuating, and (4) controlling. This paper aims to describe verses, hadiths and the relevance between theories and the interpretation of management functions. This research is library research and is included in the qualitative research approach. Data collection is carried out directly from various relevant literature including the Quran, hadith, books, and research articles. Data analysis is carried out qualitatively consisting of data reduction, data presentation, and conclusions. The results of data analysis show that the management function has the word of God that regulates it starting from the functions of planning, organizing, moving and supervising
Implementasi Perilaku Organisasi di Madrasah Aliyah Negeri Keterampilan
Authors: Asmira Asmira , Kurnia Dela , Asmendri Asmendri , Sari Milya
Published: May 2024

Organizational behavior in Madrasah Aliyah Negeri (MAN) Skills are very helpful and support the achievement and realization of the vision of the madrasah well and effectively. Organizational Behavior (PO) is a field of study that studies the interaction of individuals, groups and organizations in the context of work. PO can help MAN Skills improve their effectiveness by understanding and managing the behavior of teachers and employees and students. The main purpose of this article is to explain the concept and purpose of PO, provide examples of how PO can be implemented in MAN skills, discuss the benefits of implementing PO in MAN Skills. This research uses a qualitative approach through the literature study method. Research data is sourced from various literature, namely scientific articles, books, and other relevant scientific sources. The data analysis technique used in this study is content analysis. The results of the data analysis concluded that PO is an important style for MAN Skills to improve its effectiveness and competitiveness. By implementing PO effectively and sustainably, MAN skills can achieve its vision to become a madrasah of excellence and character
Current status of word and sentence practice teaching for 3rd grade students towards developing language capabilities at some primary schools in tuyen quang province
Authors: Yen Nguyen Hoang , Nhung Nguyen Thi Cam , Hoat Ma Trong , Hong Chuyen Dr. Nguyen Thi
Published: May 2024

The article is based on an investigation and survey of 3rd grade teachers and students regarding the current situation of word and sentence practice teaching with a focus on developing language capabilities at some primary schools in Tuyen Quang province. From the survey of teaching and learning practices of teachers and students, we have assessed the advantages, difficulties, and reasons for word and sentence practice teaching with a focus on developing language capabilities. The results show that the application of teaching methods of practicing words and sentences in the direction of developing language capabilities in some primary schools in Tuyen Quang province, despite some limitations, has brought many significant benefits, generating interest and enthusiasm for developing necessary skills and qualities for success in both learning and life for students.
MEDIDAS ECONÔMICAS ADOTADAS NO BRASIL NO ÂMBITO DA SAÚDE PÚBLICA NO DECÊNIO DE 2011 A 2021: ANÁLISE DO CENÁRIO
Authors: Lima Egilson da Silva
Published: May 2024

O artigo tem como objetivo analisar as medidas econômicas praticadas na área de saúde durante os governos Dilma Rousseff (2011-2016), Michel Temer (2016-2018) e Jair Bolsonaro (2019-2021), aferindo suas similaridades e diferenças, criando-se assim um panorama da saúde pública no Brasil no último decênio. Neste sentido, verifica-se que Dilma deu ênfase na atenção básica e na atuação focalizada dos Agentes Comunitários de Saúde (ACS), sendo que nos últimos anos de seu governo percebe-se uma retomada ao projeto político ultra neoliberal, no qual foram articuladas possibilidades de acumulação de capital, ao mesmo tem que favorecia a classe econômica dominante do Brasil, há uma redução na participação da União na despesa pública na saúde, crescendo a participação dos Estados e Municípios. No Governo Temer é retomado o projeto político ultra neoliberal, no qual foram articuladas possibilidades de acumulação de capital, ao mesmo tempo que favorecia a classe econômica dominante do Brasil, os gastos federais com saúde continuaram em queda e foi aprovada a PEC 241 (ou 55). Já no Governo Bolsonaro, apesar dos investimentos em decorrência da pandemia do COVID-19, percebe-se que os gastos permaneceram estagnados nos últimos 10 anos.
CAPACITAÇÃO DOS PROFISSIONAIS DE ENFERMAGEM NO PROCESSO DE ACOLHIMENTO DO GENITOR NO PRÉ-NATAL
Authors: Bezerra Emily Cristina Lopes , Santos Luciana Lima Benevides dos , Santos Diana Cláudia de Paiva dos
Published: May 2024

O acolhimento do genitor nas consultas pré-natais é crucial para a saúde da mãe e do bebê. Essa pesquisa explora os desafios que envolvem os procedimentos de acolhimento dos genitores por enfermeiros durante o pré-natal em Unidades Básicas de Saúde. Conforme destacado por Rocha et al. (2022), o preparo e capacitação dos enfermeiros no processo de acolhimento no pré-natal do genitor sãofundamentais para garantir a inclusão adequada do mesmo durante a assistência. A metodologia adotada na pesquisa é dada por meio de revisão bibliográfica, a natureza da pesquisa é do tipo exploratória e o conteúdo possui uma narrativa explicativa e qualitativa. A estrutura do texto é delineada por argumentos baseados em artigos científicos, trabalhos de conclusão de curso, documentos oficiais com recomendações do Ministério da Saúde do Brasil e demais publicações periódicas, que descrevem e aplicam o tema na área da saúde no Brasil. Dessa forma, o estudo evidencia a importância de políticas públicas claras e estratégias eficazes com o foco em superar esses desafios e promover mudanças positivas e consistentes no que diz respeito à capacitação de enfermeiros. Contudo, propõe-se também a ideia de que é fundamental que haja a revisão dos atuais protocolos estabelecidos pelo Ministério da Saúde do Brasil em relação ao cuidado pré-natal adequado, afim de promover a conscientização sobre o assunto.
МОЛДО КЫЛЫЧ - ПРОСВЕТИТЕЛЬ И ОБЩЕСТВЕННЫЙ ДЕЯТЕЛЬ
Authors: ИСМАЙЫЛОВА Б.З.
Published: May 2024

Предметом исследования является поэт Молдо Кылыч - просветитель и общественный деятель. Цель исследования - оценка педагогических и общественно-политических идей в произведений поэта Молдо Кылыча. Являясь образованным сыном своего времени Молдо Кылыч тяжело переживал от безграмотности, раздробленности кыргызского общества. В своих стихах автор пишет, что причиной всех бед общества заключается в отторжении от религии, от отсутсвия образования и т.д. Единственным спасением общества по мнению Кылыча является образование народа. Автор статьи рассматривает произведения Молдо Кылыча в контексте социально-экономической особенности той эпохи, обратил внимание на отношение Молдо Кылыча к изменениям в обществе. Многие проявления цивилизации, рыночные отношения, казались для него удивительными, не понятными, более того доводили до растерянности.
İlyas Efendiyev’in Piyeslerinde Vuslat Teması
Authors: Okumuş Nisa
Published: May 2024

İlyas Efendiyev (1914-1996), 20. yüzyılın ikinci yarısından itibaren Azerbaycan edebiyatının güçlü bir nesir ve piyes yazarı olarak bilinmektedir. Efendiyev, klasik ve modern sanatın izlerini taşıyan zengin bir edebî mirasa sahiptir. 1960’lı yılların kısmi de olsa demokratik atmosferi Sovyet edebiyatının gelişmesine olanak sağlamıştır. İlyas Efendiyev sırf dönemin alt yapısını hazırlayan sanatkârlardan biridir. Efendiyev, eserleri ile Çağdaş Azerbaycan edebiyatına büyük katkılar sağlamış ve yenilikler getirmiş; edebiyatı konu, biçim ve içerik bakımından geliştirmiştir. İlyas Efendiyev Azerbaycan tiyatro tarihinin en az 50 yılına damga vuran en önemli isimdir. Piyeslerinde ele aldığı konulara, kaleminin gücüne ve Azerbaycan sahnesinde en fazla oynanan eser sayısına göre “İlyas Efendiyev Tiyatrosu” olarak adlandırılan bir dönem oluşturmuştur. Çalışmamızda İlyas Efendiyev’in “Mahnı Dağlarda Kaldı”, “Hükümdar ve Kızı”, “Sevgililerin Cehennemde Vuslatı” ve “Tenha İğde Ağacı” isimli dört piyesinde vuslat teması ele alınmıştır. Asıl konusunu tarihten alan bu piyeslerin savaş, kahramanlık, ayrılık, aşk gibi temaları vardır. Aynı zamanda, adı geçen piyeslerde sevgililerin kavuşması anlamına gelen vuslat teması dikkat çekmektedir. Fakat bu tema sadece sevgiliye vuslat olarak değil vatana, geçmişe, aile bireylerine, ağaca, toprağa vuslat olarak görülmektedir. Efendiyev piyeslerinde vuslat kavramının farklı anlam yükleri olduğu, vuslatın boyutunun değiştiği ve hatta vuslatın ölümle birlikte anılması, ayrıca hicran ile vuslatın birbiriyle olan döngüsü bu konuyu inceleme ihtiyacı doğurmuştur. Çalışmamızda İlyas Efendiyev’in dört piyesi ayrı ayrı başlıklar altında değerlendirilerek bu eserlerdeki vuslat temasının boyutları ve işlenme şekilleri incelenmiştir.
Ethnomusicological Perspectives on Gaomi Miaoqiang: Unveiling the Cultural Tapestry
Authors: Tan Xuyao
Published: May 2024

This ethnomusicological study delves into the vibrant tapestry of Gaomi Miaoqiang, a traditional Chinese folk opera hailing from the Shandong province, exploring its historical evolution, linguistic intricacies, musical characteristics, and cultural implications. With a foundation rooted in the "肘鼓子" (Zhou Guzi) series of Shandong local operas, Gaomi Miaoqiang has evolved over centuries, blending folk singing styles and incorporating influences from Huagu yangge and Lüqin opera. Acknowledged as China's 67th National Intangible Cultural Heritage, Gaomi Miaoqiang represents a profound cultural legacy.The study scrutinizes the language features of Gaomi Miaoqiang, emphasizing simplicity, clarity, and the integration of local dialects, reflecting the rural life of the Gaomi community. Musical analysis unveils the operatic singing styles, instrumental accompaniment, and the evolution of musical composition. From the authentic tones of the "Original Board" to the intricate patterns of the "Dayoutou Board," Gaomi Miaoqiang's musical journey embodies emotional depth and narrative complexity. The study also explores the roles, makeup, costumes, and stage art, highlighting the art form's transition from grassroots performances to professional troupes. Furthermore, Gaomi Miaoqiang's cultural significance is illuminated, portraying its role as a conduit for spiritual solace and emotional release within local communities. Recognizing its enduring influence, the study advocates for the preservation of Gaomi Miaoqiang's distinctiveness amid urban influences. As Gaomi Miaoqiang navigates the intersection of tradition and modernity, it emerges as a cultural beacon, casting light on the rich legacy of Chinese folk opera and emphasizing the critical role of ethnomusicology in unraveling the intricate threads of cultural heritage.
Blood Donation System using Geo-Tracking and Machine Learning
Authors: Sable Sumit Shriram
Published: May 2024

This paper addresses blood donation by making use of advanced technologies to make the process easy and efficient. It emphasizes the importance of tailored systems and highlights successful studies implementing innovative solutions. Incorporating various technologies like Geographical Tracking and Machine Learning, the project explores various prediction algorithms and libraries used to build an efficient, innovative, and easy-to-use solution. The paper aims to demonstrate and explain in detail the various tools and techniques used to attempt to bring this idea to fruition, and the benefits that the usage of this technology has brought to the table not only for us as developers, but for the potential users of this app as well. Key Words: API, Java, Python, Geo-Tracking, Machine Learning, Deep Learning, Maps
Empowering the Edge: Research advances from doors 2024
Authors: Vakaliuk Tetiana A. , Semerikov Serhiy O.
Published: May 2024

The 4th Edge Computing Workshop (doors 2024) held in Zhytomyr, Ukraine, aimed to bring together researchers to share advances and applications in edge computing, a critical technology for enabling the Internet of Things and analytics close to data sources. This report summarises the event, highlighting the peer-reviewed papers covering topics from edge hardware to AI and security. The nine accepted papers, selected from 19 submissions, propose innovative approaches to advance the field. Common themes include leveraging edge computing for sensing applications and addressing resource utilisation and management challenges. The workshop stimulated valuable discussion and collaboration around these important research directions.
Yoga in Stress Alleviation: a Therapeutic and Psychodynamic Approach
Authors: Bandyopadhyay Amit , Das Tamal , Mukherjee Debajyoti
Published: May 2024

Yoga has been an increasing topic of interest over the past few years. Alleviation of stress, which is the main purpose of yoga, can be interpreted from different contexts based on one’s level of contemplation and basis of understanding.  Today, it is effectively prescribed and implemented as an alternate to medicine therapy. Based on the acute beneficial effects that yoga ought to enjoy, it is often considered by chiropractors, physiotherapists, clinicians as an integral constituent of their medical treatment. Yogasanas and exercise postures in inclusion to pranayama, are widely adopted today as remediations for various symptoms, which if left derelicted, can manifest to life-long impairments.  The therapeutic standpoint of Yoga mainly lays stress on the clinical implications and practicality of yoga today. On the contrary, the psychodynamic approach mainly emphasizes on the behavioral regulations and apprehensions of their general mechanisms. The review primarily depicts the portrayal of Yoga from times of its inception, modern day understanding of yoga from the global perspectives, and its relationship with stress. The ultimate objective of this review is to enumerate the impacts of yoga from both the therapeutic and psychodynamic standpoints thereby justifying the validity of yoga as a patent restorer of physiological homeostasis.
Dose-dependent alteration in hepatic and cerebral glucose metabolism following exposure to polystyrene microplastic in Wistar rats
Authors: Pal Sudipta , Chakraborty Susmita , Mondal Sumana
Published: May 2024

Background: Recently, microplastics (MPs) with dimensions less than 5 mm have gained more attention due to their adverse impact on the environment and living creatures. Polystyrene (PS) particle is a key element of primary microplastics, which are causing numerous health issues such as interruption of energy metabolism, oxidative stress, neurotoxicity, immunotoxicity, digestive gland disorders, reproductive disruption, and genotoxicity in marine living organisms. Method: Alteration in carbohydrate metabolism was evaluated in male Wistar rats (six weeks of age) after four weeks of oral exposure to polystyrene microplastic (PS-MP) at three different doses (0.5mg/L, 5mg/L and 50 mg/L via drinking water). Results: Polystyrene exposure caused a significant decrease in blood glucose, liver glycogen, and pyruvic acid content in liver and cerebral tissue. Free amino nitrogen content significantly altered in the liver and cerebrum in a dose-specific manner. The LDH activity was found to be decreased in the liver, whereas it increased in the cerebral cortex of rats in a dose-responsive fashion. Enzymes like glucose 6-phosphatase, GOT, GPT, and succinate dehydrogenase activities demonstrated differential effects on the liver and cerebrum of rats in terms of energy metabolism. Conclusion: It is suggested that sub-acute polystyrene exposure significantly perturbs glucose metabolism by inducing hypoglycemia associated with decreased glycolysis and increased TCA cycle enzyme function in rat liver in a dose-dependent manner. Gluconeogenesis is also affected differentially by metabolic adjustment in the studied organs.
Amelioration of L-methionine production by Alcaligenes faecalis ATCXT3624: Empirical optimization of culture conditions
Authors: Ganguly Subhadeep , Hazra Abhijit , Bhattacharyya Kaustav
Published: May 2024

Background: L-methionine production at the industrial scale suffers from various drawbacks, including the production and separation of the L-enantiomer of the amino acid methionine by chemical production methods. This strain exhibiting resilience to feedback inhibition by L-methionine provided a promising avenue for enhanced production. The present study has tried to uplift the production rate of the amino acid by a developed L-methionine-resistant strain Alcaligenes faecalis ATCXT 3624 through surpassing feedback inhibition. Methods: Empirical optimization of all fermentation conditions was studied by observing the effects of initial pH, temperature, inoculum age, medium volume, cell density, and different micronutrients, which enhanced L-methionine production. In addition, efforts were made to find suitable nitrogen and carbon sources.  Results: Eventually, 23.8±0.22 mg/mL of L-methionine was obtained under optimized fermentation conditions, which is significantly (p<0.05) higher than that produced before optimized fermentation conditions. Conclusion: Eventually, it can be assumed that the strain effectively produced the amino acid at an enhanced rate under optimized conditions.
Los principios de Desconcentración y Descentralización en el Derecho Administrativo ecuatoriano
Authors: Silva Conde Danny Israel
Published: May 2024

Los principios de desconcentración y descentralización en el Derecho Administrativo ecuatoriano surgieron en la Constitución Política de 1979 como una herramienta para distribuir de manera equitativa los recursos y servicios públicos. La Constitución de la República del Ecuador promulgado en el 2008 establece que la administración pública debe estar enfocada en el servicio comunitario y otorgar servicios adecuados a la ciudadanía. La característica fundamental de desconcentración es la transferencia de competencias a órganos de la misma línea organizativa como la entrega de competencias para lograr transparencia y calidad de servicio. El principio de descentralización se caracteriza por transferir las funciones a entidades autónomas del Estado y la descentralización territorial y sectorial, así como las funciones de los organismos autónomos en los poderes ejecutivo, legislativo, judicial y de control. Es necesario que exista la competencia como el órgano fundamental para los principios de descentralización y desconcentración en el Estado ecuatoriano, se debe comprender a la competencia como el poder de otorgar por la ley a una institución para que esta entidad pueda realizar una actividad basada en su territorio, la naturaleza, en la jerarquía, y la transferencia de funciones. En el presente trabajo investigativo se tiene como objetivo profundizar en la definición, conceptos de desconcentración y descentralización, así como su origen y características, a través del método documental, descriptivo – jurídico, el cual permitió la revisión registrada en estados de arte por medio de la lectura y el análisis de la información de fuentes bibliográficas.
AVTOTRANSPORT VOSITALARINING TOVAR KODLARINI TAKOMILLASHTIRISH
Authors: Hamroyev Ulug‘bek Rustamovich
Published: May 2024

Ushbu maqolada Bojxona amaliyotida ixtisoslashgan transport vositalarini import yoki eksport qiluvchilarda gidravlika “avtokran” avtotransport vositalariga nisbatan tasniflanishida 2 ta tovar pozitsiyasida tasniflanishida havola moyilligi va munozarali holatlari yuzaga kelishi kuzatiladi. Model LT1130 avtokranining texnik tavsifini 8705 va 8426 tovar pozitsiyalariga nisbatan tasniflanishi to‘g‘risida nazariy asoslari keltirilgan. Shuningdek, LT1130 model avtokrani talqin etishning asosiy qoidasi (OPI)ning 1 va 2- qoidalariga muvofiq 8705 tovar pozitsiyasi, ya’ni 8705 10 subpozitsiyasida tasniflanishi to‘g‘risida ma’lumotlar bayon qilingan.
BENZOKSAZOLIN-2-TION PROPION KISLOTA VA Сo (II) IONI ASOSIDA YANGI KOMPLEKS SINTEZI HAMDA UNING IQ-SPEKTRAL VA NAZARIY TAHLILLARI
Authors: Amanov Baxodir Sharifovich , Ashurov Jamshid Mengnorovich , Rasulov Abdusamat Abdujabborovich , Alimnazarov Bekmurod Xurramovich , Sharifova Lola Baxodirovna
Published: May 2024

Ushbu maqolada benzoksazolin-2-tion propion kislota (BPK) va kobalt (II) ioni bilan yangi [Co(BPK)2(H2O)4]H2O tarkibli kompleksining sintezi hamda tadqiqot natijalari keltirilgan. Sintez qilingan metallokompleksning tarkibi, molekulyar va kristall tuzilishlari  rentgen tuzilish tahlili (RTT) usulida aniqlangan. RTT natijalariga ko‘ra kompleksda kobalt (II) kationiga ikkita BPK ligandlari monodentat holatda va to‘rtta suv molekulalari ham monodentat holatda bog’lanib oktaedr tuzilishli akvokompleks hosil qiladi. Bundan tashqari, assimetrik birlikdagi tashqi koordinatsion soha bitta suv molekulasini o‘z ichiga oladi. Sintez qilingan metallokompleksning IQ-spektri hamda RTT ma’lumotlari asosida molekulalararo ta’sirlashish energiyalari va  Hirshfeld sirt tahlili ham o‘rganilgan.
PHOLOMOIDES SPECIOSA O’SIMLIGINING BIOLOGIK FAOL MODDALARI
Authors: Abdullayeva Feruza Qamaraliyevna , Mexmonxonov Murodulla Maqsudxon o’g’li , Xaydarova Dilrabo Rаhimjonovna , Abdullayev Shavkat Vohidovich
Published: May 2024

Ushbu maqolada  Phlomoides speciosa o’simligining  biologik faol birikmalarni aniqlash uchun  o’tkazilgan sifat tahlili  yoritib berilgan. Aktivlangan ko’mir adsorbenti yordamida spirtli fraksiyalarga bo’linib kraxmal va algin kislotasi ilk bor Phlomoides speciosa o’simligidan ajratildi.
ХИМИЧЕСКИЙ СОСТАВ ГЛИЦИНА И ЕГО ПРИМЕНЕНИЕ В МЕДИЦИНЕ
Authors: Обидова Шохсанам Акромджон кизи
Published: May 2024

В статье с использованием механизма действия и квантово-химического метода изучен химический состав глицина – простейшего представителя аминокислот, применяемых при заболеваниях нервной системы. При этом в результате изучения геометрии и электронного строения глицина была оценена и уточнена специфическими методами реакционная способность молекулы.
Natural Language Processing Tools for Romanian – Going Beyond a Low-Resource Language.
Authors: Nitu Melania , Dascalu Mihai
Published: May 2024

Advances in Natural Language Processing bring innovative instruments to the educational field to improve the quality of the didactic process by addressing challenges like language barriers and creating personalized learning experiences. Most research in the domain is dedicated to high-resource languages, such as English, while languages with limited coverage, like Romanian, are still underrepresented in the field. Operating on low-resource languages is essential to ensure equitable access to educational opportunities and to preserve linguistic diversity. Through continuous investments in developing Romanian educational instruments, we are rapidly going beyond a low-resource language. This paper presents recent educational instruments and frameworks dedicated to Romanian, leveraging state-of-the-art NLP techniques, such as building advanced Romanian language models and benchmarks encompassing tools for language learning, text comprehension, question answering, automatic essay scoring, and information retrieval. The methods and insights gained are transferable to other low-resource languages, emphasizing methodological adaptability, collaborative frameworks, and technology transfer to address similar challenges in diverse linguistic contexts. Two use cases are presented, focusing on assessing student performance in Moodle courses and extracting main ideas from students’ feedback. These practical applications in Romanian academic settings serve as examples for enhancing educational practices in other less-resourced languages.
Sex-related differences in benefits of anticoagulation therapy in elderly patients with atrial fibrillation: a subanalysis of the EMERG-AF study
Authors: Varona Mercedes , Martín Alfonso , Sánchez Juan , Tamargo Juan , Cancio Manuel , Sánchez Susana , Carbajosa José , Fernández de Simón Amparo , Ríos José , del Arco Carmen , Ormaetxe José , Suero Coral , Coll-Vinent Blanca
Published: May 2024

Objetivos. Analizar los beneficios y seguridad a largo plazo de la anticoagulación oral (ACO) prescrita en los servicios de urgencias (SU) a pacientes mayores con fibrilación auricular (FA) y las diferencias en función del sexo. Método. Se trata de un análisis post-hoc del estudio EMERG-AF. Se incluyeron pacientes consecutivos $ 75 años, que consultaron en 62 SU por FA. Se recogieron datos clínicos y ACO. La variable principal estuvo compuesta por muerte, tromboembolia o sangrado mayor en 1 año. Resultados. Se incluyeron 690 pacientes, 386 mujeres (55,9%). Al alta, 575 pacientes (83,3%) estaban con ACO. En 96 de ellos se inició en el SU. Tras 1 año, la variable principal sucedió en 158 pacientes (22,9%): 118 (17,1%) fallecieron, 22 (2,7%) tuvieron una complicación tromboembólica y 34 (4,9%) una hemorragia mayor. Tras ajustar por las principales características clínicas, la ACO se asoció a una reducción en la variable principal (HR: 0,372, IC 95%: 0,236-0,587, p < 0,001), pero no se asoció con la hemorragia mayor. En las mujeres, la ACO se asoció con una reducción en la variable principal (HR: 0,372, IC 95%: 0,236-0,587, p < 0,001) y una menor mortalidad (HR: 0,281, IC 95%: 0,168-0,469, p < 0,001), incluidos pacientes con nueva prescripción y en aquellos dados de alta. Esta asociación no alcanzó significación en los hombres. Conclusiones. La prescripción de ACO en los SU a pacientes mayores con FA es segura y contribuye a reducir la mortalidad. En este grupo etario, las mujeres se benefician más que los hombres de iniciar la ACO en la fase aguda.
Changes in cortical and hippocampal EEG activity accompanying spontaneous electrocortical seizures in rats
Authors: Gralewicz Sławomir , Łuczak Cezary
Published: May 2024

The purpose of the present study was to find out whether the occurrence of bursts of spontaneous spike-wave discharges (SWD) in rat neocortex is related to a particular state of vigilance (level of arousal), as some authors suggested, or rather to transitions from one state to another as postulated by others. Patterns of cortical and hippocampal EEG preceding and following the SWD bursts were studied in rats. It has been found that the beginning of an SWD episode is usually preceded by a shift of cortical activity toward synchronization and replacement of the rhythmic slow activity (RSA) in the hippocampus by large irregular activity (LIA). After SWD, the cortical activity is usually more desynchronized and RSA is present more frequently than just before its onset. An analysis of selected episode-free and episode-rich EEG segments revealed that SWD's occur in abundance at the periods characterized by frequent changes of the hippocampal EEG pattern but are absent during the periods in which long-lasting RSA trains dominate in the record. Thus, the data confirm that SWD occurrence is related more to transitions from one state to another than to a particular state as such. They also indicate that the preferable conditions for SWD's appear when arousal is decreasing from a moderate to a lower level.
Effects of MK-801 and ganglioside GM1 on postischemic prostanoid release and hippocampal lesion in gerbil brain
Authors: Łazarewicz Jerzy , Salińska Elżbieta , Speina Elżbieta , Gadamski Roman
Published: May 2024

In this study Mongolian gerbils were submitted to a normothermic bilateral carotid ligation lasting 5 min. A noncompetitive antagonist of NMDA receptors, MK-801, 0.8 mg/kg, was injected i.p. 30 min before ischemia, or the ganglioside GM1, 30 mg/kg, was given i.p. for 3 days, twice a day. The morphology of the hippocampal CA1 neurones and the brain content of cyclooxygenase metabolites of arachidonic acid: prostaglandin 6-keto PGF1 alpha and thromboxane Tx B2 were studied. Untreated ischemia induced the accumulation in brain of the 6-keto PGF1 alpha and Tx B2 immunoreactive materials, and resulted in a lesion of 70% of CA1 neurones. In the MK-801- and GM1-pretreated groups the postischemic levels of Tx B2 were significantly decreased. However MK-801 and GM1 did not prevent damage to the CA 1 neurones in gerbils normothermic after ischemia, whereas a partial neuroprotection was observed in hypothermic, MK-801 treated gerbils. The results of this study indicate that NMDA receptors may participate in the mechanism of postischemic release of eicosanoids in brain. They also confirm a potential modulatory role of gangliosides. These results are discussed in terms of the involvement of cyclooxygenase metabolites of arachidonic acid in the mechanism of a selective delayed neuronal damage to the hippocampus CA1 after ischemia.
The role of dopamine in the regulation of melatonin biosynthesis in vertebrate retina
Authors: Zawilska Jolanta
Published: May 2024

The vertebrate retina rhythmically synthesizes melatonin, a hormone involved in the regulation of several intraocular processes cued by environmental lighting conditions. The rhythm of retinal melatonin production, with maximal synthesis at night in darkness, is driven by the photoperiodic environment to which animals are exposed, and is generated by an endogenous circadian clock(s). This article reviews data on the role of dopamine, an established retinal neurotransmitter and paracrine factor, as a mediator of acute suppressive and entrainment action of light on the melatonin generating system in the retina. Special emphasis is given to the characterization of dopamine receptor types involved in the control of retinal melatonin formation.
Dissociable neuronal mechanism for different crossmodal correspondence effects in humans
Authors: Jaap Carina , Rose Michael
Published: May 2024

Crossmodal correspondences (CMCs) refer to associations between seemingly arbitrary stimulus features in different sensory modalities. Pitch‑size correspondences refer to the strong association of e.g., small objects with high pitches. Pitch‑elevation correspondences refer to the strong association of e.g., visuospatial elevated objects with high pitches. We used functional magnetic resonance imaging (fMRI) to study the neural components, which underlie the CMCs in pitch‑size and spatial pitch‑elevation. This study focuses on answering the question of whether or not different CMCs are driven by similar neural mechanisms. The comparison of congruent against incongruent trials allows the estimation of CMC effects across different CMCs. The analysis of the measured neural activity in different CMCs strongly pointed toward different mechanisms which are involved in the processing of pitch‑size and pitch‑elevation correspondences. Differential, whole brain effects were observed within the superior parietal lobule (SPL), cerebellum and Heschls’ gyrus (HG). Further, the angular gyrus (AnG), the intraparietal sulcus (IPS) and anterior cingulate cortex (ACC) were engaged in processing the CMCs but showed different effects for processing congruent compared to incongruent stimulus presentations. Within pitch‑size significant effects in the AnG and ACC were found for congruent stimulus presentations whereas for pitch‑elevation, significant effects in the ACC and IPS were found for incongruent stimulus presentations. In summary, the present results indicated differential neural processing in different simple audio‑visual CMCs.
Coagulant and flocculant effect of Opuntia ficus-indica in water treatment
Authors: Gaviria-Bedoya Andrés , Rubio-Clemente Ainhoa
Published: May 2024

One of the most relevant processes in potable and wastewater treatment plants is coagulation-flocculation, which gives rise to the destabilization of dissolving solids, for the subsequent generation of flocs using a coagulating agent. Aluminum sulfate (Al2(SO4)3) is the most used coagulant internationally, due to its efficiency and low cost. However, its utilization can leave a residue of aluminum in water and bring with it a variety of health problems due to its bioaccumulative characteristics, implying both the deterioration of ecosystems and problems for human health. In this regard, it is necessary to establish alternatives that avoid the permanence of this heavy metal in water, so that the mucilage of Opuntia ficus-indica becomes a natural coagulant of great interest. Likewise, it is a sustainable alternative for water treatment, given its characteristics of biodegradability, low toxicity, commercial cost, relative abundance, renewability, and high efficiency, allowing a low generation of sludge, which can be biodegraded through a fair treatment with a high valuation spectrum
A Novel Approach to a Recurrent Fuzzy Logic Controller Design Applied to Systems with Multiple Disturbances
Authors: Cruz Múñoz-Esparza José , Jaime-Leal José Enrique
Published: May 2024

In any process, control plays a vital role in the quality of the product. The influence of a controller's operation on a process is linked to its success or failure. However, using a controller that works properly presents several obstacles, such as non-linearity or the lack of a model that adequately represents the behavior of the process. Different approaches have been devised and studied to deal with these difficulties. One of the most promising and widely applied and studied in recent years is fuzzy control due to its ability to operate systems with no precise plant model. Herein, a set of rules and a fuzzy control structure are proposed, with fewer design parameters than a conventional fuzzy controller and better performance. The global stochastic optimization tool Differential Evolution is used to obtain the design parameters of the proposed fuzzy controller.
Comparing the antibacterial activity of plants against bacteria
Authors: Uddin Sameer
Published: May 2024

Plants and their secondary metabolites are potentially beneficial since they produce a number of medicinal substances. They have a variety of biological functions and characteristics that are influenced by various outside variables. The objective of this research is to examine the antibacterial activity of two plant extracts, Helicteresisora and Piper longum, against gramme positive bacteria, Staphylococcus epidermidis, and gramme negative bacteria, Escherichia coli, using the micro dilution method. Additionally, the quantity and efficiency of these extracts will be examined in relation to changes in extraction and storage temperatures. The extracts were extracted at 90°C temperatures. To determine whether Helicteresisora and Piper longum were present, qualitative testing and statistical test carried out. By the time the trials were over, it was determined that Helicteresisora appears to be more efficient against Escherichia coli and Staphylococcus epidermidis than Piper longum, as indicated by a graphical representation. it can be concluded that the inhibition zone of Helicteresisora and Piper longum against Staphylococcus epidermidis and Escherichia coli shows significant differences as most standard deviation values do not overlap
Bacterial mediated synthesis and characterization of copper oxide nanoparticles and their antimicrobial and dye remediation applications
Authors: Gota1 Tirishya , Kulkarni1 Pragya
Published: May 2024

The globe is currently dealing with serious issues related to health and water pollution. Some frequent sources of water contamination are municipal sewage systems and industrial water.This study examined the antibacterial capabilities of CuO NPs made using a green approach, as well as their impact on polluted water. Because of their many uses and unique qualities, copper oxide nanoparticles, or CuO NPs, have garnered a lot of interest in a variety of sectors, including biomedical sciences and nanomedicine. There are several ways to create copper oxide nanoparticles, including chemical, physical, and biological techniques. The physicochemical methods use a lot of energy, are costly, and discharge a lot of hazardous chemicals into the environment. Conversely, the biological approach offers a simple, comfortable, economical, dependable, and environmentally beneficial means of producing copper oxide nanoparticles. Systematic analysis with UV-Vis, FTIR, XRD and Antimicrobial study validated the synthesis of Copper oxide nanoparticles. The bio mediated synthesis of copper oxide nanoparticles is examined in this review, along with their medicinal uses, which include antibacterial, antifungal, and antiviral.
A vivência de familiares de pacientes oncológicos em cuidados paliativos: uma revisão de escopo
Authors: Silva Mirele Emily Pires da , Lima Leticia Viotto , Campos Elisangela Cristina de , Barbosa Guilherme Correa , Jamas Milena Temer
Published: May 2024

Esta pesquisa objetivou analisar os mecanismos de adaptação psicológica utilizados na vivência de familiares de pacientes oncológicos em cuidados paliativos. Método: Trata-se de uma revisão de escopo envolvendo as bases de dados SCOPUS, Web of Science, PubMed e LILACS. Selecionou-se 33 artigos a partir dos critérios de inclusão: publicações que abordavam o coping, sem delimitação de tempo ou idioma. Os critérios de exclusão foram: artigos duplicados e aqueles que não respondiam à questão norteadora. Resultados: Identificaram temas importantes através da análise dos estudos, relacionados com a invisibilidade do cuidador, concomitantemente com o fato de que a maioria dos cuidadores familiares eram do sexo feminino; as principais estratégias adaptativas foram evitação, esperança, espiritualidade e apoio familiar. Conclusão: Este estudo permitiu evidenciar as principais estratégias de enfrentamento utilizadas pelos familiares de pacientes oncológicos em cuidados paliativos. Algumas intervenções como novos instrumentos de identificação do tipo de coping e escala de satisfação dos cuidadores com a equipe de saúde poderiam ser facilitadores do cuidado com esse público.
Students’ learning obstacle in operations of integer
Authors: Kurniasi Rima , Nurjanah Nurjanah , Cahya Endang
Published: May 2024

This study aims to describe the learning obstacles faced by students in the operation of integers. The research method used is a qualitative method with a case study design. The data was taken from 16 students in grade 7, a junior high school in Batang Hari, Jambi. The data collection technique used was triangulation data. There are written tests, interviews with both students and the teacher, and document analysis. The data collection instrument used was a test of integer operations, interview guidelines, and documents (lesson plan and textbook). The results of the research showed that there are learning obstacles in the operations of integers, namely, ontogenic obstacles (difference in knowledge between natural number operations and integer operations), epistemological obstacles (limited understanding), and didactical obstacles (obstacles that come from the didactic system). Other researchers can create lesson plans based on the obstacles found in this research.
Analysis of Health Services at Sukamerindu Community Health Center in Bengkulu City
Authors: Rinaldo Rofi , Aminuddin Achmad , Agus Nourfarozi
Published: May 2024

This study assesses the quality of health services at Sukamerindu Community Health Center in Bengkulu City, Indonesia, utilizing a descriptive qualitative research approach. Through observation, interviews, and documentation, the research examines five dimensions: Available & Sustainable, Reasonably Acceptable, Achievability, Easy to Reach, and Quality. While the health center effectively organizes services, achieves reasonable acceptability, and is easy to reach, challenges exist in guaranteeing service products and optimizing physical facilities. Overall, the health services at Sukamerindu Community Health Center fall short of community expectations. Addressing these gaps is essential for enhancing the health center's effectiveness and aligning services with community needs and preferences.
Hemoglobina y parámetros indicativos de anemia ferropénica en adultos mayores con diabetes mellitus II, Centro de Salud Las Naves 2023
Authors: Guapulema-Peñaloza Ginger Jessica , Zambrano-Macías Coralia
Published: May 2024

La anemia ferropénica es el resultado de una deficiencia de hierro, que afecta directamente la síntesis de hemoglobina, esta es una proteína presente en los glóbulos rojos que desempeña un papel crucial en el transporte de oxígeno a los tejidos y la eliminación de dióxido de carbono. El objetivo de la investigación fue analizar la hemoglobina y parámetros indicativos de anemia ferropénica en adultos mayores con diabetes mellitus 2, Centro de Salud Las Naves 2023. La metodología presentada para esta fue un enfoque cualitativo y descriptivo retrospectivo. Se trabajó con un total de 80 adultos mayores de 60 años con diagnóstico de diabetes mellitus tipo 2. Los resultados se presentaron en tablas que muestran el perfil de hemoglobina, parámetros indicativos de anemia ferropénica y relación entre los niveles de hemoglobina y estos parámetros. Los hallazgos revelaron una asociación significativa entre niveles alterados de hemoglobina, hematocrito, el volumen corpuscular medio, concentración de hemoglobina corpuscular media, ferritina sérica y nivel de hierro sérico, y la presencia de anemia ferropénica. La prevalencia de anemia ferropénica en la población estudiada fue del 8.75%. Se concluyó que, la prevalencia de la anemia ferropénica en los adultos mayores que presentan diabetes mellitus tipo 2 no es tan alta comparada con otras investigaciones.
Estrategias pedagógicas para potenciar la habilidad lectora en el entorno digital: un enfoque transformador en estudiantes de primer año de bachillerato técnico automotriz
Authors: Molina-Romero Ana María , Molina-Romero María Rosa , Cacoango-Yucta Washington Iván , Zúñiga-Delgado Mireya Stefanía
Published: May 2024

La capacidad de leer es esencial para el desarrollo académico y personal, ya que permite a los estudiantes adquirir nuevos conocimientos y desarrollar el pensamiento crítico. A medida que los estudiantes avanzan en su educación, enfrentan el desafío de hacer la transición del aprendizaje a la lectura, un cambio de paradigma que ocurre en el cuarto grado. Este estudio tuvo como objetivo examinar el impacto de las estrategias pedagógicas digitales en las habilidades de comprensión lectora en estudiantes de primer año de bachillerato técnico automotriz de la unidad educativa. Doctor Andrés F. Córdova. Se utilizó un enfoque mixto, combinando métodos cualitativos y cuantitativos para proporcionar una comprensión completa de la influencia de las estrategias digitales en la comprensión del lector. Para recopilar datos sobre la percepción y eficacia de estas estrategias se utilizó una encuesta estructurada en escala Likert, complementada con entrevistas a docentes. Se realizó un análisis estadístico de las respuestas de 60 estudiantes y cuatro profesores, evaluando las perspectivas de estudiantes y profesores sobre el uso de tecnologías educativas digitales. Los datos mostraron una actitud generalmente positiva hacia el uso de estrategias pedagógicas digitales, tanto entre estudiantes como entre profesores. Las entrevistas revelaron un consenso entre los docentes sobre la necesidad de personalizar el aprendizaje y utilizar herramientas digitales alineadas con los objetivos educativos. La cuidadosa selección de contenidos digitales y la personalización del aprendizaje son claves para el éxito de estas estrategias. Sin embargo, se identificaron desafíos como el acceso equitativo a la tecnología y la necesidad de formación docente continua.
MANIFESTAÇÕES GASTROINTESTINAIS E COMPLICAÇÕES CLÍNICAS DA SÍNDROME DE PEUTZ-JEGHERS: REVISÃO INTEGRATIVA DE LITERATURA
Authors: Almeida Ana Valéria Santos Pereira de , Mendonça Filho Carlos Alberto , Santos Gustavo Araujo dos , Oliveira Marcos Vinicius Costa , Bezerra Plutarco Rodrigues
Published: May 2024

O objetivo desta revisão integrativa é aprofundar o entendimento das manifestações gastrointestinais e complicações clínicas associadas à Síndrome de Peutz-Jeghers (SPJ), contribuindo para o avanço do conhecimento científico sobre essa condição genética rara. A SPJ é caracterizada por pólipos hamartomatosos no trato gastrointestinal e pigmentação mucocutânea, apresentando complicações graves, como sangramento gastrointestinal e risco aumentado de câncer. Portanto, destaca-se a importância do reconhecimento precoce e do manejo adequado das manifestações gastrointestinais e das complicações potencialmente graves. A metodologia inclui uma revisão integrativa de literatura, com critérios de inclusão envolvendo estudos sobre SPJ e suas características gastrointestinais, publicados nos últimos cinco anos em inglês, português ou espanhol. Os resultados desta revisão ressaltaram a gravidade das complicações associadas à SPJ, incluindo sangramento gastrointestinal, anemia, intussuscepção e um risco aumentado de câncer, especialmente após a quarta década de vida. Além disso, a análise revelou a importância fundamental do diagnóstico precoce por meio de métodos de imagem, tais como cápsula endoscópica, enterografia por ressonância magnética, por tomografia computadorizada ou colonoscopia. Conclui-se que o manejo eficaz da SPJ requer diagnóstico precoce, vigilância regular e intervenção terapêutica oportuna para prevenir complicações graves e melhorar a qualidade de vida dos pacientes.