bluuebunny/crossref_metadata_2025 huggingface dataset:
On Hostile Soil: Spanish Republican Diplomats in Berlin at the Onset of the Spanish Civil War
Authors: MORENTE FRANCISCO
Published: November 2016

German intervention in the Spanish Civil War was decisive for its development and result. Traditionally scholars have focused their attention on the support given by the Third Reich to the military rebels; however, they have widely neglected the study of the relationship between Germany and the Spanish Republic during the first four months of the war, when both countries maintained diplomatic relations. This paper aims at exploring a crucial aspect of that historical period, namely the circumstances of the Spanish diplomats in Berlin during those first four months, and the strategies that the German and the Spanish governments carried out in the harsh diplomatic battle that they ended up fighting. The author explains the difficult working conditions of the Spanish diplomats who were loyal to the Republic and stayed in Berlin in July 1936, when most of their colleagues deserted. Finally, he explores how the German Foreign Affairs Department, in collaboration with the Gestapo, managed to restrain the Spanish Republic diplomatic action in Germany.
Neuroscience Fiction as Eidolá: Social Reflection and Neuroethical Obligations in Depictions of Neuroscience in Film
Authors: WURZMAN RACHEL , YADEN DAVID , GIORDANO JAMES
Published: November 2016

Neuroscience and neurotechnology are increasingly being employed to assess and alter cognition, emotions, and behaviors, and the knowledge and implications of neuroscience have the potential to radically affect, if not redefine, notions of what constitutes humanity, the human condition, and the “self.” Such capability renders neuroscience a compelling theme that is becoming ubiquitous in literary and cinematic fiction. Such neuro-SciFi (or “NeuroS/F”) may be seen as eidolá: a created likeness that can either accurately—or superficially, in a limited way—represent that which it depicts. Such eidolá assume discursive properties implicitly, as emotionally salient references for responding to cultural events and technological objects reminiscent of fictional portrayal; and explicitly, through characters and plots that consider the influence of neurotechnological advances from various perspectives. We argue that in this way, neuroS/F eidolá serve as allegorical discourse on sociopolitical or cultural phenomena, have power to restructure technological constructs, and thereby alter the trajectory of technological development. This fosters neuroethical responsibility for monitoring neuroS/F eidolá and the sociocultural context from which—and into which—the ideas of eidolá are projected. We propose three approaches to this: evaluating reciprocal effects of imaginary depictions on real-world neurotechnological development; tracking changing sociocultural expectations of neuroscience and its uses; and analyzing the actual process of social interpretation of neuroscience to reveal shifts in heuristics, ideas, and attitudes. Neuroethicists are further obliged to engage with other discourse actors about neuroS/F interpretations to ensure that meanings assigned to neuroscientific advances are well communicated and more fully appreciated.
The Dialectic between Confrontation and Commitment: Religious-Zionism and the Settlement Project
Authors: Hellinger Moshe , Hershkowitz Isaac , Susser Bernard
Published: November 2016

Religious Zionists have been the driving force behind the settlement project in Israel for the past 40 years. They often see settling in the Greater Land of Israel as a messianic activity. It might be thought that when state policy clashes with radical messianic movements, the result would be violent, bloody confrontations. This study seeks to explain why this has not been the case in Israel despite the dismantling of settlements in the Sinai and Gaza and the controversial Oslo process. Although there has been turmoil and resistance, most religious Zionists have refrained from serious violence. We suggest that a “theological-normative balance” prevents all-out de-legitimation of the state and life-threatening violence against it.
Remembering Irving I. Gottesman: Twin Research Colleague and Friend Extraordinaire/Research Studies: Face-Lift Technique Comparison in Identical Twins; Raising Preterm Twins; Fetal Behavior in Dichorionic Twin Pregnancies; Co-Bedding and Stress Reduction in Twins/Public Interest: Identical Co-Twins’ Same Day Delivery; Teaching Twins in Bosnia; Twin Auctioneers;Sister, the Play
Authors: Segal Nancy L.
Published: November 2016

Dr Irving I. Gottesman, a colleague, friend, and long-time member of the International Society of Twin Studies passed away on June 29, 2016. His contributions to twin research and some personal reflections are presented to honor both the man and the memory. This tribute is followed by short reviews of twin research concerning differences between cosmetic surgical techniques, the rearing of preterm twins, behavioral observations of dichorionic fetal twins, and the outcomes of co-bedding twins with reference to stress reduction. Interesting and informative articles in the media describe identical co-twins who delivered infants on the same day, educational policies regarding twins in Bosnia and the United Kingdom, unusual practices of twin auctioneers, and a theatrical production,Sister, featuring identical twins in the leading roles.
Normale und abnorme kolposkopische Befunde
Authors: Betschart Cornelia , Ghisu Gian-Piero , Fink Daniel
Published: November 2016

Zusammenfassung. Die Kolposkopie ist ein wichtiges Instrument in der Früherkennung des Zervixkarzinoms. Die Kombination von Zytologie und Kolposkopie bleibt unabhängig von der Möglichkeit der HPV-Typenbestimmung zurzeit die akkurateste Methode, hochgradige intrazervikale Läsionen der Portio zu detektieren. Dank der Kolposkopie kann die zytologische Diagnose bestätigt oder revidiert, die Grösse und Lokalisation des dysplastischen Befundes erfasst und die notwendige Therapie sowie Nachsorge eingeleitet werden. Die HPV-Bestimmung sagt wohl etwas über das onkogene Potenzial des HPV aus, nicht jedoch, ob eine Dysplasie vorliegt, die über Jahre in ein Karzinom übergehen kann. Kolposkopisch abnorme Befunde der Ektozervix werden mit einer Knipsbiopsie histologisch abgeklärt, intrazervikale Befunde mittels einer endozervikalen Kürettage und eines tiefen Zytobrushes.
Patientenorientierte Psychotherapieforschung
Authors: Stulz Niklaus
Published: November 2016

Zusammenfassung. Die Wirksamkeit von Psychotherapie ist für eine Vielzahl von psychischen Störungen durch zahlreiche randomisierte kontrollierte Studien (RCT) und Metaanalysen gut belegt. Aus Sicht der praktisch tätigen Psychotherapeuten sind RCT jedoch aufgrund ihrer Eigenschaften (z.B. strenge Ein- und Ausschlusskriterien) oft nur mässig klinisch relevant. Ziel der patientenorientierten Psychotherapieforschung ist es, die psychotherapeutische Praxis durch empirisch fundierte und auf den Einzelfall zugeschnittene Rückmeldungen zum Psychotherapieverlauf unmittelbar zu unterstützen. Dazu beschäftigt sich die patientenorientierte Psychotherapieforschung mit dem Monitoring und der Vorhersage des individuellen Fortschritts während der Behandlung, mit dessen Evaluation durch Entscheidungsregeln und mit der zeitnahen Rückmeldung des Therapieverlaufs an die Behandler und Patienten während der noch laufenden Behandlung.
CME: Bakterielle Meningitis bei Erwachsenen
Authors: Jeger Victor , Hasse Barbara , Hildenbrand Florian
Published: November 2016

Zusammenfassung. Die akute bakterielle Meningitis ist ein seltenes Krankheitsbild in der hausärztlichen Praxis mit jedoch hoher Mortalität. Deshalb ist die rasche Diagnose, unmittelbare Hospitalisierung und Einleitung einer empirischen Antibiotikatherapie eine grosse Herausforderung. Die klassische klinische Trias bestehend aus Fieber, Meningismus und Bewusstseinsveränderung ist unspezifisch, und oft sind erste Symptome bei einer Grippe oder einem gastrointestinalen Infekt sehr ähnlich. Bereits bei geringem Verdacht sollte eine Liquorpunktion erfolgen, wobei diese die erste Gabe von Ceftriaxon i.v. nicht verzögern darf. In der empirischen Therapie müssen Meningokokken, Pneumokokken und je nach Risikoprofil auch Listerien sowie mögliche resistente Keime abgedeckt werden.
Salinity tolerance loci revealed in rice using high-throughput non-invasive phenotyping
Authors: Al-Tamimi Nadia , Brien Chris , Oakey Helena , Berger Bettina , Saade Stephanie , Ho Yung Shwen , Schmöckel Sandra M. , Tester Mark , Negrão Sónia
Published: November 2016

High-throughput phenotyping produces multiple measurements over time, which require new methods of analyses that are flexible in their quantification of plant growth and transpiration, yet are computationally economic. Here we develop such analyses and apply this to a rice population genotyped with a 700k SNP high-density array. Two rice diversity panels, indica and aus, containing a total of 553 genotypes, are phenotyped in waterlogged conditions. Using cubic smoothing splines to estimate plant growth and transpiration, we identify four time intervals that characterize the early responses of rice to salinity. Relative growth rate, transpiration rate and transpiration use efficiency (TUE) are analysed using a new association model that takes into account the interaction between treatment (control and salt) and genetic marker. This model allows the identification of previously undetected loci affecting TUE on chromosome 11, providing insights into the early responses of rice to salinity, in particular into the effects of salinity on plant growth and transpiration.
Axin2-expressing cells execute regeneration after skeletal injury
Authors: Ransom R. C. , Hunter D. J. , Hyman S. , Singh G. , Ransom S. C. , Shen E. Z. , Perez K. C. , Gillette M. , Li J. , Liu B. , Brunski J. B. , Helms J. A.
Published: November 2016

The mammalian skeleton performs a diverse range of vital functions, requiring mechanisms of regeneration that restore functional skeletal cell populations after injury. We hypothesized that the Wnt pathway specifies distinct functional subsets of skeletal cell types, and that lineage tracing of Wnt-responding cells (WRCs) using the Axin2 gene in mice identifies a population of long-lived skeletal cells on the periosteum of long bone. Ablation of these WRCs disrupts healing after injury, and three-dimensional finite element modeling of the regenerate delineates their essential role in functional bone regeneration. These progenitor cells in the periosteum are activated upon injury and give rise to both cartilage and bone. Indeed, our findings suggest that WRCs may serve as a therapeutic target in the setting of impaired skeletal regeneration.
Exosomes derived from embryonal and alveolar rhabdomyosarcoma carry differential miRNA cargo and promote invasion of recipient fibroblasts
Authors: Ghayad Sandra E. , Rammal Ghina , Ghamloush Farah , Basma Hussein , Nasr Rihab , Diab-Assaf Mona , Chelala Claude , Saab Raya
Published: November 2016

Rhabdomyosarcoma (RMS) is an aggressive childhood soft tissue tumor, which exists in oncoprotein PAX-FOXO1 fusion positive and fusion negative subtypes, with the fusion-positive RMS being characterized by a more aggressive clinical behavior. Exosomes are small membranous vesicles secreted into body fluids by multiple cell types, including tumor cells, and have been implicated in metastatic progression through paracrine signaling. We characterized exosomes secreted by a panel of 5 RMS cell lines. Expression array analysis showed that, for both fusion-positive and fusion-negative cells, exosome miRNA clustered well together and to a higher extent than cellular miRNA. While enriched miRNA in exosomes of fusion-negative RMS cells were distinct from those of fusion-positive RMS cells, the most significant predicted disease and functions in both groups were related to processes relevant to cancer and tissue remodelling. Functionally, we found that RMS-derived exosomes exerted a positive effect on cellular proliferation of recipient RMS cells and fibroblasts, induced cellular migration and invasion of fibroblasts, and promoted angiogenesis. These findings show that RMS-derived exosomes enhance invasive properties of recipient cells, and that exosome content of fusion-positive RMS is different than that of fusion-negative RMS, possibly contributing to the different metastatic propensity of the two subtypes.
Tropomyosin Receptor Kinase C Targeted Delivery of a Peptidomimetic Ligand-Photosensitizer Conjugate Induces Antitumor Immune Responses Following Photodynamic Therapy
Authors: Kue Chin Siang , Kamkaew Anyanee , Voon Siew Hui , Kiew Lik Voon , Chung Lip Yong , Burgess Kevin , Lee Hong Boon
Published: November 2016

Tropomyosin receptor kinase C (TrkC) targeted ligand-photosensitizer construct, IYIY-diiodo-boron-dipyrromethene (IYIY-I2-BODIPY) and its scrambled counterpart YIYI-I2-BODIPY have been prepared. IYIY-I2-BODIPY binds TrkC similar to neurotrophin-3 (NT-3), and NT-3 has been reported to modulate immune responses. Moreover, it could be shown that photodynamic therapy (PDT) elevates antitumor immune responses. This prompted us to investigate the immunological impacts mediated by IYIY-I2-BODIPY in pre- and post-PDT conditions. We demonstrated that IYIY-I2-BODIPY (strong response) and YIYI-I2-BODIPY (weak response) at 10 mg/kg, but not I2-BODIPY control, increased the levels of IL-2, IL-4, IL-6 and IL-17, but decreased the levels of systemic immunoregulatory mediators TGF-β, myeloid-derived suppressor cells and regulatory T-cells. Only IYIY-I2-BODIPY enhanced the IFN-γ+ and IL-17+ T-lymphocytes, and delayed tumor growth (~20% smaller size) in mice when administrated daily for 5 days. All those effects were observed without irradiation; when irradiated (520 nm, 100 J/cm2, 160 mW/cm2) to produce PDT effects (drug-light interval 1 h), IYIY-I2-BODIPY induced stronger responses. Moreover, photoirradiated IYIY-I2-BODIPY treated mice had high levels of effector T-cells compared to controls. Adoptive transfer of immune cells from IYIY-I2-BODIPY-treated survivor mice that were photoirradiated gave significantly delayed tumor growth (~40–50% smaller size) in recipient mice. IYIY-I2-BODIPY alone and in combination with PDT modulates the immune response in such a way that tumor growth is suppressed. Unlike immunosuppressive conventional chemotherapy, IYIY-I2-BODIPY can act as an immune-stimulatory chemotherapeutic agent with potential applications in clinical cancer treatment.
Resting-state high-frequency heart rate variability is related to respiratory frequency in individuals with severe mental illness but not healthy controls
Authors: Quintana Daniel S. , Elstad Maja , Kaufmann Tobias , Brandt Christine L. , Haatveit Beathe , Haram Marit , Nerhus Mari , Westlye Lars T. , Andreassen Ole A.
Published: November 2016

Heart rate variability (HRV) has become central to biobehavioral models of self-regulation and interpersonal interaction. While research on healthy populations suggests changes in respiratory frequency do not affect short-term HRV, thus negating the need to include respiratory frequency as a HRV covariate, the nature of the relationship between these two variables in psychiatric illness is poorly understood. Therefore, the aim of this study was to investigate the association between HRV and respiratory frequency in a sample of individuals with severe psychiatric illness (n = 55) and a healthy control comparison group (n = 149). While there was no significant correlation between HF-HRV and respiration in the control group, we observed a significant negative correlation in the psychiatric illness group, with a 94.1% probability that these two relationships are different. Thus, we provide preliminary evidence suggesting that HF-HRV is related to respiratory frequency in severe mental illness, but not in healthy controls, suggesting that HRV research in this population may need to account for respiratory frequency. Future work is required to better understand the complex relationship between respiration and HRV in other clinical samples with psychiatric diseases.
Digital Detection of Exosomes by Interferometric Imaging
Authors: Daaboul George G. , Gagni Paola , Benussi Luisa , Bettotti Paolo , Ciani Miriam , Cretich Marina , Freedman David S. , Ghidoni Roberta , Ozkumur Ayca Yalcin , Piotto Chiara , Prosperi Davide , Santini Benedetta , Ünlü M. Selim , Chiari Marcella
Published: November 2016

Exosomes, which are membranous nanovesicles, are actively released by cells and have been attributed to roles in cell-cell communication, cancer metastasis, and early disease diagnostics. The small size (30–100 nm) along with low refractive index contrast of exosomes makes direct characterization and phenotypical classification very difficult. In this work we present a method based on Single Particle Interferometric Reflectance Imaging Sensor (SP-IRIS) that allows multiplexed phenotyping and digital counting of various populations of individual exosomes (>50 nm) captured on a microarray-based solid phase chip. We demonstrate these characterization concepts using purified exosomes from a HEK 293 cell culture. As a demonstration of clinical utility, we characterize exosomes directly from human cerebrospinal fluid (hCSF). Our interferometric imaging method could capture, from a very small hCSF volume (20 uL), nanoparticles that have a size compatible with exosomes, using antibodies directed against tetraspanins. With this unprecedented capability, we foresee revolutionary implications in the clinical field with improvements in diagnosis and stratification of patients affected by different disorders.
Modulation of light-driven arousal by LIM-homeodomain transcription factor Apterous in large PDF-positive lateral neurons of the Drosophila brain
Authors: Shimada Naoto , Inami Show , Sato Shoma , Kitamoto Toshihiro , Sakai Takaomi
Published: November 2016

Apterous (Ap), the best studied LIM-homeodomain transcription factor in Drosophila, cooperates with the cofactor Chip (Chi) to regulate transcription of specific target genes. Although Ap regulates various developmental processes, its function in the adult brain remains unclear. Here, we report that Ap and Chi in the neurons expressing PDF, a neuropeptide, play important roles in proper sleep/wake regulation in adult flies. PDF-expressing neurons consist of two neuronal clusters: small ventral-lateral neurons (s-LNvs) acting as the circadian pacemaker and large ventral-lateral neurons (l-LNvs) regulating light-driven arousal. We identified that Ap localizes to the nuclei of s-LNvs and l-LNvs. In light-dark (LD) cycles, RNAi knockdown or the targeted expression of dominant-negative forms of Ap or Chi in PDF-expressing neurons or l-LNvs promoted arousal. In contrast, in constant darkness, knockdown of Ap in PDF-expressing neurons did not promote arousal, indicating that a reduced Ap function in PDF-expressing neurons promotes light-driven arousal. Furthermore, Ap expression in l-LNvs showed daily rhythms (peaking at midnight), which are generated by a direct light-dependent mechanism rather than by the endogenous clock. These results raise the possibility that the daily oscillation of Ap expression in l-LNvs may contribute to the buffering of light-driven arousal in wild-type flies.
Mechanism of Consistent Gyrus Formation: an Experimental and Computational Study
Authors: Zhang Tuo , Razavi Mir Jalil , Li Xiao , Chen Hanbo , Liu Tianming , Wang Xianqiao
Published: November 2016

As a significant type of cerebral cortical convolution pattern, the gyrus is widely preserved across species. Although many hypotheses have been proposed to study the underlying mechanisms of gyrus formation, it is currently still far from clear which factors contribute to the regulation of consistent gyrus formation. In this paper, we employ a joint analysis scheme of experimental data and computational modeling to investigate the fundamental mechanism of gyrus formation. Experimental data on mature human brains and fetal brains show that thicker cortices are consistently found in gyral regions and gyral cortices have higher growth rates. We hypothesize that gyral convolution patterns might stem from heterogeneous regional growth in the cortex. Our computational simulations show that gyral convex patterns may occur in locations where the cortical plate grows faster than the cortex of the brain. Global differential growth can only produce a random gyrification pattern, but it cannot guarantee gyrus formation at certain locations. Based on extensive computational modeling and simulations, it is suggested that a special area in the cerebral cortex with a relatively faster growth speed could consistently engender gyri.
Molecular analysis of the factorless internal ribosome entry site in Cricket Paralysis virus infection
Authors: Kerr Craig H. , Ma Zi Wang , Jang Christopher J. , Thompson Sunnie R. , Jan Eric
Published: November 2016

The dicistrovirus Cricket Paralysis virus contains a unique dicistronic RNA genome arrangement, encoding two main open reading frames that are driven by distinct internal ribosome entry sites (IRES). The intergenic region (IGR) IRES adopts an unusual structure that directly recruits the ribosome and drives translation of viral structural proteins in a factor-independent manner. While structural, biochemical, and biophysical approaches have provided mechanistic details into IGR IRES translation, these studies have been limited to in vitro systems and little is known about the behavior of these IRESs during infection. Here, we examined the role of previously characterized IGR IRES mutations on viral yield and translation in CrPV-infected Drosophila S2 cells. Using a recently generated infectious CrPV clone, introduction of a subset of mutations that are known to disrupt IRES activity failed to produce virus, demonstrating the physiological relevance of specific structural elements within the IRES for virus infection. However, a subset of mutations still led to virus production, thus revealing the key IRES-ribosome interactions for IGR IRES translation in infected cells, which highlights the importance of examining IRES activity in its physiological context. This is the first study to examine IGR IRES translation in its native context during virus infection.
Imprinting of cerebral cytochrome P450s in offsprings prenatally exposed to cypermethrin augments toxicity on rechallenge
Authors: Singh Anshuman , Agrahari Anita , Singh RadhaDutt , Yadav Sanjay , Srivastava Vikas , Parmar Devendra
Published: November 2016

Epigenetic studies were carried in the rat offsprings, born to dams treated with cypermethrin (orally; 5.0 mg/kg) from gestation day (GD) 5 to 21 and rechallenged with cypermethrin (orally; 10 mg/kg for 6 days), at adulthood (12 weeks) to understand the mechanism underlying the overexpression of cerebral cytochrome P450s (CYPs) in exposed offsprings. The data revealed alterations in histone H3 acetylation and DNA methylation in promoter regions of CYP1A- and 2B- isoenzymes in the brain isolated from rechallenged animals. Further, bisulphite sequencing revealed critical CpG methylation changes in BARBIE BOX (Barbiturate response element) and BTE (Basal transcription element) in promoter of CYP2B1 in the brain isolated from rechallenged animals. Western blotting and DNA laddering/fragmentation studies revealed a greater magnitude of increase in the signalling pathways associated with apoptosis in the rechallenged animals. The data have indicated that overexpression of cerebral CYPs could be due to the imprinting of CYPs. Further, increased apoptosis observed in the rechallenged offsprings has suggested that these epigenetic changes in CYPs may predispose the prenatally exposed offsprings to the neurotoxic effects of other centrally acting drugs and chemicals when subsequently rechallenged later at life.
Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1
Authors: Gerakis Yannis , Dunys Julie , Bauer Charlotte , Checler Fréderic
Published: November 2016

The aspartyl protease β-site APP cleaving enzyme, BACE1, is the rate-limiting enzyme involved in the production of amyloid-β peptide, which accumulates in both sporadic and familial cases of Alzheimer’s disease and is at the center of gravity of the amyloid cascade hypothesis. In this context, unravelling the molecular mechanisms controlling BACE1 expression and activity in both physiological and pathological conditions remains of major importance. We previously demonstrated that Aβ controlled BACE1 transcription in an NFκB-dependent manner. Here, we delineate an additional cellular pathway by which natural and synthetic Aβ42 oligomers enhance active X-box binding protein XBP-1s. XBP-1s lowers BACE1 expression and activity indirectly, via the up-regulation of the ubiquitin-ligase HRD1 that acts as an endogenous down-regulator of BACE1. Thus, we delineate a novel pathway by which cells could compensate for Aβ42 oligomers production and thus, associated toxicity, by triggering a compensatory mechanism aimed at lowering BACE-1-mediated Aβ production by a molecular cascade involving XBP-1s and HRD1. It thus identifies HRD1 as a potential target for a novel Aβ-centered therapeutic strategy.
Quantitative determination of calcium ions by means of enhanced fluorescence of silver nanocluster complex
Authors: Lu Liang , An Xueqin , Huang Wenxue
Published: November 2016

A simple and green method for the synthesis of fluorescent silver nanocluster–nanoparticle complexes (AgNCs–AgNPs) is presented.
A new flow-injection chromatography method exploiting linear-gradient elution for fast quantitative screening of parabens in cosmetics
Authors: Barbatsi Margarita , Koupparis Michael , Economou Anastasios
Published: November 2016

Linear gradient elution flow injection chromatography with flow rate modulation was used for the determination of 4 parabens.
Graphene oxide–alizarin yellow R–magnetic chitosan nanocomposite: a selective and efficient sorbent for sub-trace determination of aluminum in water samples
Authors: Sadeghi Seyed Jamal , Seidi Shahram , Ghasemi Jahan B.
Published: November 2016

Dispersive solid phase extraction using graphene oxide–alizarin yellow R–magnetic chitosan nanocomposite as a selective sorbent for sub-trace determination of aluminum.
Chiral nanoscale pores created during the surface explosion of tartaric acid on Cu(111)
Authors: Therrien A. J. , Lawton T. J. , Mernoff B. , Lucci F. R. , Pushkarev V. V. , Gellman A. J. , Sykes E. C. H.
Published: November 2016

The autocatalytic decomposition of tartaric acid on Cu(111) exhibits unique kinetics, which are linked to a hexagonal surface structure adopted at high coverage.
Sequence-specific recognition of methylated DNA by an engineered transcription activator-like effector protein
Authors: Tsuji Shogo , Futaki Shiroh , Imanishi Miki
Published: November 2016

We created a 5mC-selective TALE-repeat and controlled the expression of an endogenous gene in a methylation status-dependent manner.
A platform for the development of novel biosensors by configuring allosteric transcription factor recognition with amplified luminescent proximity homogeneous assays
Authors: Li Shanshan , Zhou Li , Yao Yongpeng , Fan Keqiang , Li Zilong , Zhang Lixin , Wang Weishan , Yang Keqian
Published: November 2016

Using isolated allosteric transcription factors as recognition elements, a versatile platform was established in vitro to develop sensitive biosensors for the detection of various chemicals.
Plug-and-playable fluorescent cell imaging modular toolkits using the bacterial superglue, SpyTag/SpyCatcher
Authors: Moon Hyojin , Bae Yoonji , Kim Hansol , Kang Sebyung
Published: November 2016

Simple plug-and-playable fluorescent cell imaging modular toolkits are established and target cells are visualized with selective colors on demand.
Membrane-less organic–inorganic aqueous flow batteries with improved cell potential
Authors: Leung P. K. , Martin T. , Shah A. A. , Anderson M. A. , Palma J.
Published: November 2016

A new organic–inorganic membrane-less flow battery based on low cost materials with stable performance.
Phase engineering of MoS2 through GaN/AlN substrate coupling and electron doping
Authors: Ouyang Bin , Ou Pengfei , Wang Yongjie , Mi Zetian , Song Jun
Published: November 2016

A first principles study was performed to investigate the interface induced phase stability transition within MoS2 on top of GaN and AlN.
Diffusive dynamics of polymer chains in an array of nanoposts
Authors: Ye Yi , Du Zhongjie , Tian Ming , Zhang Liqun , Mi Jianguo
Published: November 2016

The diffusion of the head, side, and middle segments in confined polymer chains displays different dynamics in different directions.
DFT calculations in the assignment of solid-state NMR and crystal structure elucidation of a lanthanum(iii) complex with dithiocarbamate and phenanthroline
Authors: Gowda Vasantha , Laitinen Risto S. , Telkki Ville-Veikko , Larsson Anna-Carin , Antzutkin Oleg N. , Lantto Perttu
Published: November 2016

Structure of a novel rare-earth lanthanum(iii) complex resolved by a combination of DFT modelling, NMR spectroscopy, and single crystal XRD.
(E)-4-Methyl-N-((quinolin-2-yl)ethylidene)aniline as ligand for IIB supramolecular complexes: synthesis, structure, aggregation-induced emission enhancement and application in PMMA-doped hybrid material
Authors: Wang Ani , Fan Ruiqing , Dong Yuwei , Chen Wei , Song Yang , Wang Ping , Hao Sue , Liu Zhigang , Yang Yulin
Published: November 2016

Complexes 1–5 with AIEE properties were synthesized and 1 was incorporated into PMMA.
Hierarchical ternary Ni–Co–Se nanowires for high-performance supercapacitor device design
Authors: Guo Kailu , Cui Shizhong , Hou Hongwei , Chen Weihua , Mi Liwei
Published: November 2016

Large-scale uniform Ni–Co–Se bimetallic ternary nanowires have been successfully synthesized through a successive cation exchange.
Controlling the magnetic properties of dysprosium metallofullerene within metal–organic frameworks
Authors: Li Yongjian , Wang Taishan , Meng Haibing , Zhao Chong , Nie Mingzhe , Jiang Li , Wang Chunru
Published: November 2016

The hysteresis and quantum tunneling of magnetism for a metallofullerene DySc2N@C80 single-molecule magnet were modulated through trapping in MOF-177.
Mesoporous lignite-coke as an effective adsorbent for coal gasification wastewater treatment
Authors: An Hongguang , Liu Zhenqiang , Cao Xiaoxin , Teng Jilin , Miao Wenhua , Liu Junfeng , Li Ruozheng , Li Peng
Published: November 2016

Mesoporous lignite-coke as an effective adsorbent for high molecular weight refractory compounds in coal gasification wastewater treatment.
Molecular frame photoemission by a comb of elliptical high-order harmonics: a sensitive probe of both photodynamics and harmonic complete polarization state
Authors: Veyrinas K. , Gruson V. , Weber S. J. , Barreau L. , Ruchon T. , Hergott J.-F. , Houver J.-C. , Lucchese R. R. , Salières P. , Dowek D.
Published: November 2016

Due to the intimate anisotropic interaction between an XUV light field and a molecule resulting in photoionization (PI), molecular frame photoelectron angular distributions (MFPADs) are most sensitive probes of both electronic/nuclear dynamics and the polarization state of the ionizing light field. Consequently, they encode the complex dipole matrix elements describing the dynamics of the PI transition, as well as the three normalized Stokes parameters s1, s2, s3 characterizing the complete polarization state of the light, operating as molecular polarimetry. The remarkable development of advanced light sources delivering attosecond XUV pulses opens the perspective to visualize the primary steps of photochemical dynamics in time-resolved studies, at the natural attosecond to few femtosecond time-scales of electron dynamics and fast nuclear motion. It is thus timely to investigate the feasibility of measurement of MFPADs when PI is induced e.g., by an attosecond pulse train (APT) corresponding to a comb of discrete high-order harmonics. In the work presented here, we report MFPAD studies based on coincident electron-ion 3D momentum imaging in the context of ultrafast molecular dynamics investigated at the PLFA facility (CEA-SLIC), with two perspectives: (i) using APTs generated in atoms/molecules as a source for MFPAD-resolved PI studies, and (ii) taking advantage of molecular polarimetry to perform a complete polarization analysis of the harmonic emission of molecules, a major challenge of high harmonic spectroscopy. Recent results illustrating both aspects are reported for APTs generated in unaligned SF6 molecules by an elliptically polarized infrared driving field. The observed fingerprints of the elliptically polarized harmonics include the first direct determination of the complete s1, s2, s3 Stokes vector, equivalent to (ψ, ε, P), the orientation and the signed ellipticity of the polarization ellipse, and the degree of polarization P. They are compared to so far incomplete results of XUV optical polarimetry. We finally discuss the comparison between the outcomes of photoionization and high harmonic spectroscopy for the description of molecular photodynamics.
Reaction rate theory: summarising remarks
Authors: Chandler David , Manolopoulos David E.
Published: November 2016

This paper summarizes the contributions to the Faraday Discussion on reaction rate theory. The topics range from contemporary usage of transition state theory, including rare event sampling, to instantons and non-adiabatic dynamics.
DNA and BSA damage inhibitory activities, and anti-acetylcholinesterase, anti-porcine α-amylase and antioxidant properties of Dolichos lablab beans
Authors: Habib Hosam M. , Theuri Serah W. , Kheadr Ehab , Mohamed Fedah E.
Published: November 2016

The underutilized Kenyan variety of Dolichos lablab bean seeds serve as a good source of natural antioxidants, which can probably be effective in reducing the risk of occurrence of several diseases.
High-throughput metabolomics approach reveals new mechanistic insights for drug response of phenotypes of geniposide towards alcohol-induced liver injury by using liquid chromatography coupled to high resolution mass spectrometry
Authors: Zhang Tianlei , Zhang Aihua , Qiu Shi , Sun Hui , Han Ying , Guan Yu , Wang Xijun
Published: November 2016

Alcohol-induced liver injury (ALD) shows obvious metabolic disorders, categorized by a wide range of metabolite abnormalities.
An organic polymer-grafted ionic liquid as a catalyst for the cycloaddition of CO2 to epoxides
Authors: Xing Dan , Lu Bin , Wang Hongxia , Zhao Jingxiang , Cai Qinghai
Published: November 2016

Chemical fixation of CO2 to a cyclic carbonate catalyzed by benzyl chloride polymer-supported imidazolium ionic liquids.
Metal-mediated generation of triazapentadienate-terminated di- and trinuclear μ2-pyrazolate NiIIspecies and control of their nuclearity
Authors: Andrusenko Elena V. , Kabin Evgeniy V. , Novikov Alexander S. , Bokach Nadezhda A. , Starova Galina L. , Kukushkin Vadim Yu.
Published: November 2016

Nuclearity control of nickel(ii)–azole systems for the generation of well-defined (azolate)2NiIIspecies.
Chemo-enzymatic modification of eukaryotic mRNA
Authors: Muttach Fabian , Muthmann Nils , Rentmeister Andrea
Published: November 2016

Posttranscriptional modification at its 5′ cap renders mRNA amenable to bioorthogonal click reactions which can be performed in living cells.
Spin-labelled diketopiperazines and peptide–peptoid chimera by Ugi-multi-component-reactions
Authors: Sultani Haider N. , Haeri Haleh H. , Hinderberger Dariush , Westermann Bernhard
Published: November 2016

Ugi-multi-component reactions can be used to synthesize spin-labelled compounds suitable for EPR.
Asymmetric chemoenzymatic synthesis of 1,3-diols and 2,4-disubstituted aryloxetanes by using whole cell biocatalysts
Authors: Vitale Paola , Perna Filippo Maria , Agrimi Gennaro , Scilimati Antonio , Salomone Antonio , Cardellicchio Cosimo , Capriati Vito
Published: November 2016

A simple and efficient chemoenzymatic approach for the asymmetric synthesis of 1,3-diols and 2,4-disubstituted aryloxetanes has been established.
Synthesis and self-assembly of diblock glycopolypeptide analogues PMAgala-b-PBLG as multifunctional biomaterials for protein recognition, drug delivery and hepatoma cell targeting
Authors: Wang Zhao , Sheng Ruilong , Luo Ting , Sun Jingjing , Cao Amin
Published: November 2016

PMAgala-b-PBLG glycopolypeptide analogues might serve as redox-responsive, highly biocompatible multifunctional biomaterial platforms for practical applications.
Preparation of water-soluble hyperbranched polymers with tunable thermosensitivity using chain-growth CuAAC copolymerization
Authors: Shi Yi , Cao Xiaosong , Zou Lei , Gan Weiping , Gao Haifeng
Published: November 2016

Thermoresponsive hyperbranched polymers with dangling oligo(ethylene oxide) chain on every monomer unit were constructed using the chain-growth copper-catalyzed azide–alkyne cycloaddition (CuAAC) copolymerization of two AB2-F monomers.
Stepwise membrane fouling model for shear-enhanced filtration of alfalfa juice: experimental and modeling studies
Authors: Zhang Wenxiang , Ding Luhui , Jaffrin Michel Y. , Grimi Nabil , Tang Bing
Published: November 2016

Stepwise membrane fouling model.
Metal–organic framework channelled graphene composite membranes for H2/CO2separation
Authors: Li Wanbin , Zhang Yufan , Su Pengcheng , Xu Zehai , Zhang Guoliang , Shen Chong , Meng Qin
Published: November 2016

MOF nanosheets werein situcrystallized between rGO to form composite membranes with excellent H2/CO2separation performance.
Thermally activated delayed fluorescence blue dopants and hosts: from the design strategy to organic light-emitting diode applications
Authors: Godumala Mallesham , Choi Suna , Cho Min Ju , Choi Dong Hoon
Published: November 2016

Thermally activated delayed fluorescence materials exhibited outstanding external quantum efficiencies in OLEDs along with good CIE color coordinates and improved device stabilities. Hence these are most promising for commercialization of OLEDs.
14-Year Results of Bilateral versus Single Internal Thoracic Artery Grafts for Left-Sided Myocardial Revascularization in Young Diabetic Patients
Authors: Delalic Alem , Eszlari Edgar , Eichinger Walter , Gansera Brigitte
Published: November 2016

Objectives Despite encouraging late outcomes, the use of bilateral internal thoracic artery (BITA) grafting for myocardial revascularization in diabetic patients remains controversial because of an increased risk of sternal wound complications. In the present study, early- and long-term outcomes of the use of left-sided BITA versus single internal thoracic artery (SITA) grafting in young (< 65 years of age) diabetic patients were reviewed retrospectively.

Methods A total of 250 propensity score pair-matched diabetic patients, operated on between February 2000 and December 2011, receiving either BITA (n = 125) or SITA (n = 125) grafting were analyzed retrospectively. In each group, 104 patients were males, and mean age was 60.1 ± 5.3 years. Follow-up was 2.1 to 14.8 years (mean, 9.3 ± 3.5 years) and complete for 100%.

Results Incidence of deep sternal wound infection was 2.4 versus 3.2% (p = 0.722). Rethoracotomy due to bleeding occurred in 4.8 versus 3.2% (p = 0.608). The 5-, 10-, and 14-year estimates of survival were 93.4, 76.6, and 67.5% (BITA) versus 89.5, 81.5, and 32.8% (SITA); p = 0.288. Freedom from reangiography/intervention (60.5 vs. 63.9%) during follow-up was comparable (p = 0.507) as well as infarction rate (93.8 vs. 95.1%, p = 0.833) and redoes (p = 0.672, exclusively valve surgery) were comparable. Freedom from thromboembolic or cerebrovascular events did not show any significant differences (94.0 vs. 94.0%, p = 0.78). Multivariate analysis identified poor ejection fraction as predictor for decreased long-term survival. Neither age nor gender or urgency had an influence on long-term mortality.

Conclusion Left-sided BITA grafting may be performed routinely even in diabetic patients without increased incidence of postoperative wound-healing complications. Survival rates after 5, 10, and 14 years were comparable for BITA and SITA grafting.
Damit ihr mich versteht
Authors: Maxeiner Sandra , Rühle Hedda
Published: November 2016

Viele Depressive fühlen sich wertlos und als Bürde für ihre Mitmenschen. Oft sehen sie Suizid als einzigen Ausweg. Kommunizieren Depressive ihre Erkrankung nach außen, stoßen sie häufig auf Unverständnis. Dies bestätigt ihr Gefühl, unverstanden zu sein. Mit unserer Logik als Maßstab lässt sich die innere Not von Betroffenen nicht begreifen. Urteilsfreies Zuhören dagegen hilft, ihre Situation nachzuempfinden.
Online measurements of surface tensions and viscosities based on the hydrodynamics of Taylor flow in a microchannel
Authors: Sun Yanhong , Guo Chaohong , Jiang Yuyan , Wang Tao , Zhang Lei
Published: November 2016

This paper demonstrates an online measurement technique which can measure both surface tension and viscosity for confined fluids in microfluidic systems. The surface tension and viscosity are determined by monitoring the liquid film thickness deposited in a microchannel based on the hydrodynamics of Taylor flow. Measurements were carried out for pure liquids and binary aqueous liquid mixtures. The results agreed well with reference data and theoretical models. This novel method has considerable potential for measuring dynamic interfacial tension of complex mixtures. Furthermore, it offers opportunity for integrating property measurement with two-phase flow in microchannel, opening new lines of applications.
Introducing new reactivity descriptors: “Bond reactivity indices.” Comparison of the new definitions and atomic reactivity indices
Authors: Sánchez-Márquez Jesús
Published: November 2016

A new methodology to obtain reactivity indices has been defined. This is based on reactivity functions such as the Fukui function or the dual descriptor and makes it possible to project the information of reactivity functions over molecular orbitals instead of the atoms of the molecule (atomic reactivity indices). The methodology focuses on the molecule’s natural bond orbitals (bond reactivity indices) because these orbitals (with physical meaning) have the advantage of being very localized, allowing the reaction site of an electrophile or nucleophile to be determined within a very precise molecular region. This methodology gives a reactivity index for every Natural Bond Orbital (NBO), and we have verified that they have equivalent information to the reactivity functions. A representative set of molecules has been used to test the new definitions. Also, the bond reactivity index has been related with the atomic reactivity one, and complementary information has been obtained from the comparison. Finally, a new atomic reactivity index has been defined and compared with previous definitions.
Analyzing signal attenuation in PFG anomalous diffusion via a non-Gaussian phase distribution approximation approach by fractional derivatives
Authors: Lin Guoxing
Published: November 2016

Anomalous diffusion exists widely in polymer and biological systems. Pulsed-field gradient (PFG) techniques have been increasingly used to study anomalous diffusion in nuclear magnetic resonance and magnetic resonance imaging. However, the interpretation of PFG anomalous diffusion is complicated. Moreover, the exact signal attenuation expression including the finite gradient pulse width effect has not been obtained based on fractional derivatives for PFG anomalous diffusion. In this paper, a new method, a Mainardi-Luchko-Pagnini (MLP) phase distribution approximation, is proposed to describe PFG fractional diffusion. MLP phase distribution is a non-Gaussian phase distribution. From the fractional derivative model, both the probability density function (PDF) of a spin in real space and the PDF of the spin’s accumulating phase shift in virtual phase space are MLP distributions. The MLP phase distribution leads to a Mittag-Leffler function based PFG signal attenuation, which differs significantly from the exponential attenuation for normal diffusion and from the stretched exponential attenuation for fractional diffusion based on the fractal derivative model. A complete signal attenuation expression Eα(−Dfbα,β*) including the finite gradient pulse width effect was obtained and it can handle all three types of PFG fractional diffusions. The result was also extended in a straightforward way to give a signal attenuation expression of fractional diffusion in PFG intramolecular multiple quantum coherence experiments, which has an nβ dependence upon the order of coherence which is different from the familiar n2 dependence in normal diffusion. The results obtained in this study are in agreement with the results from the literature. The results in this paper provide a set of new, convenient approximation formalisms to interpret complex PFG fractional diffusion experiments.
Small-charge underwater explosion bubble experiments under various boundary conditions
Authors: Cui P. , Zhang A. M. , Wang S. P.
Published: November 2016

Small-charge underwater explosion experiments were performed to investigate bubbles subjected to gravity and various boundary conditions, including single boundary (free surface and rigid wall boundary), combined boundaries of free surface and solid wall, solid wall boundaries with a circular opening, and resilient wall boundaries. With high speed camera and pressure sensors, the behavior of explosion bubbles was studied and features of associated pressure pulses were analyzed. Detailed image analysis on the final stages of bubble collapse was carried out and revealed a possible explanation for the weakening of pressure waves at bubble rebound as the bubble approaches a wall boundary. Certain features also indicate that the magnitude of the pressure peaks induced by bubble rebound is related to the shape of the bubble shape during collapse. Pressure pulses arising from the two types of bubble behavior, specifically the collision of an annular jet and the impact of a jet with the wall boundary, were measured. Other curious types of bubble behavior were found, including jetting induced by suction when a bubble collapses covering a circular opening on a solid wall, and bubble splitting in interaction with a resilient wall boundary.
Quantum hydrodynamics in the rotating reference frame
Authors: Trukhanova Mariya Iv.
Published: November 2016

In this paper, we apply quantum hydrodynamics (QHD) to study the quantum evolution of a system of spinning particles and particles that have the electric dipole moments (EDM) in the rotating reference frame. The method presented is based on the many-particle microscopic Schrodinger equation in the rotating reference frame. Fundamental QHD equations for charged or neutral spinning and EDM-bearing particles were shaped due to this method and contain the spin-dependent inertial force field. The polarization dynamics in systems of neutral particles in the rotating frame is shown to cause formation of a new type of waves, the dipole-inertial waves. We have analyzed elementary excitations in a system of neutral polarized fluids placed into an external electric field in 2D and 3D cases. We predict the novel type of 2D dipole-inertial wave and 3D-polarization wave modified by rotation in systems of particles with dipole-dipole interactions.
Verification of the SPEC code in stellarator geometries
Authors: Loizu J. , Hudson S. R. , Nührenberg C.
Published: November 2016

We present the first calculations performed with the Stepped-Pressure Equilibrium Code (SPEC) in stellarator geometry. Provided a boundary magnetic surface, stellarator vacuum fields with islands are computed and verified to machine precision, for both a classical l = 2 stellarator field and a Wendelstein 7-X limiter configuration of the first experimental campaign. Beyond verification, a detailed comparison of SPEC solutions to Biot-Savart solutions for the corresponding coil currents is shown. The level of agreement is quantified, and the error is shown to be dominated by the accuracy with which the boundary representation is given. Finally, partially relaxed stellarator equilibria are computed with SPEC, and verification is presented with force-balance down to machine precision.