bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and validation of a high throughput whole blood thrombolysis plate assay
Authors: Bonnard T. , Law L. S. , Tennant Z. , Hagemeyer C. E.
Published: May 2017

The objective of this work was to develop a high throughput assay for testing in vitro the thrombolytic activity using citrated whole blood samples, and to overcome the limitations of currently available techniques. We successfully developed a method that involves forming halo shaped, tissue factor induced, whole blood clots in 96 well plates, and then precisely measuring the thrombolysis process with a spectrophotometer plate reader. We here describe the implementation of this novel method, which we refer to as halo assay, and its validation with plasmin, urokinase and tissue plasminogen activator at different doses. The resulting data is a highly detailed thrombolysis profile, allowing comparison of different fibrinolytic agents. The time point analysis allows kinetic data to be collected and calculated to determine key parameters such as the activation time and the rate of fibrinolysis. We also assessed the capacity of the model to study the effect of clot maturation time on the fibrinolytic rate, an aspect of thrombosis rather unexplored with currently available methods, but of increasing importance in drug development. This novel thrombolysis assay could be an extremely useful research tool; to study the complex process of thrombolysis, and a valuable translational clinical tool; as a screening device to rapidly identify hypo- or hyper-fibrinolysis.
High visibility first-order subwavelength interference based on light pulse storage via electromagnetically induced transparency
Authors: Li Zhixiang , Liu Jianji , Fan Hongming , Liu Jiachen , Zhang Guoquan
Published: May 2017

We achieved high visibility first-order subwavelength interference based on light pulse storage and retrieval technique via electromagnetically induced transparency (EIT) effect in a Pr3+:Y2SiO5 crystal. The interference field distribution of a double-slit was first stored in a Pr3+:Y2SiO5 crystal based on EIT effect, and then it was read out by a spatially modulated readout beam. The retrieved output field is proportional to the product of the input interference field of the double-slit and the spatially modulated readout field. High visibility first-order subwavelength interference with an effective wavelength of λ/n, where λ is the wavelength of the input light field and n is any positive integer, can be obtained by designing the spatial modulation structure of the readout field. Experimentally, first-order subwavelength interference with an effective wavelength of λ/3 and a visibility of 67% were demonstrated. Such first-order subwavelength interference has important applications on high resolution optical lithography.
Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants
Authors: Böhm Sybille , Riedmayr Lisa M. , Nguyen O. N. Phuong , Gießl Andreas , Liebscher Toni , Butz Elisabeth S. , Schön Christian , Michalakis Stylianos , Wahl-Schott Christian , Biel Martin , Becirovic Elvir
Published: May 2017

Mutations in the photoreceptor outer segment (OS) specific peripherin-2 lead to autosomal dominant retinitis pigmentosa (adRP). By contrast, mutations in the peripherin-2 homolog Rom-1 cause digenic RP in combination with certain heterozygous mutations in peripherin-2. The mechanisms underlying the differential role of peripherin-2 and Rom-1 in RP pathophysiology remained elusive so far. Here, focusing on two adRP-linked peripherin-2 mutants, P210L and C214S, we analyzed the binding characteristics, protein assembly, and rod OS targeting of wild type (perWT), mutant peripherin-2 (perMT), or Rom-1 complexes, which can be formed in patients heterozygous for peripherin-2 mutations. Both mutants are misfolded and lead to decreased binding to perWT and Rom-1. Furthermore, both mutants are preferentially forming non-covalent perMT-perMT, perWT-perMT, and Rom-1-perMT dimers. However, only perWT-perMT, but not perMT-perMT or Rom-1-perMT complexes could be targeted to murine rod OS. Our study provides first evidence that non-covalent perWT-perMT dimers can be targeted to rod OS. Finally, our study unravels unexpected opposing roles of perWT and Rom-1 in rod OS targeting of adRP-linked peripherin-2 mutants and suggests a new treatment strategy for the affected individuals.
Optogenetic excitation of cholinergic inputs to hippocampus primes future contextual fear associations
Authors: Hersman Sarah , Cushman Jesse , Lemelson Noah , Wassum Kate , Lotfipour Shahrdad , Fanselow Michael S.
Published: May 2017

Learning about context is essential for appropriate behavioral strategies, but important contingencies may not arise during initial learning. A variant of contextual fear conditioning, context pre-exposure facilitation, allows us to directly test the relationship between novelty-induced acetylcholine release and later contextual associability. We demonstrate that optogenetically-enhanced acetylcholine during initial contextual exploration leads to stronger fear after subsequent pairing with shock, suggesting that novelty-induced acetylcholine release primes future contextual associations.
Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial
Authors: Canfora Emanuel E. , van der Beek Christina M. , Jocken Johan W. E. , Goossens Gijs H. , Holst Jens J. , Olde Damink Steven W. M. , Lenaerts Kaatje , Dejong Cornelis H. C. , Blaak Ellen E.
Published: May 2017

Short-chain fatty acids (SCFA), formed by microbial fermentation, are believed to be involved in the aetiology of obesity and diabetes. This study investigated the effects of colonic administration of physiologically relevant SCFA mixtures on human substrate and energy metabolism. In this randomized, double-blind, crossover study, twelve normoglycaemic men (BMI 25–35 kg/m2) underwent four investigational days, during which SCFA mixtures (200 mmol/L) high in either acetate (HA), propionate (HP), butyrate (HB) or placebo (PLA) were rectally administered during fasting and postprandial conditions (oral glucose load). Before and for two hours after colonic infusions, indirect calorimetry was performed and blood samples were collected. All three SCFA mixtures increased fasting fat oxidation (P < 0.01), whilst resting energy expenditure increased after HA and HP compared with PLA (P < 0.05). In addition, all three SCFA mixtures increased fasting and postprandial plasma peptide YY (PYY) concentrations, and attenuated fasting free glycerol concentrations versus PLA (P < 0.05). Colonic infusions of SCFA mixtures, in concentrations and ratios reached after fibre intake, increased fat oxidation, energy expenditure and PYY, and decreased lipolysis in overweight/obese men. Human intervention studies are warranted to investigate whether these effects translate into long-term benefits for body weight control and insulin sensitivity in the obese insulin resistant state.
The role of retinol dehydrogenase 10 in the cone visual cycle
Authors: Xue Yunlu , Sato Shinya , Razafsky David , Sahu Bhubanananda , Shen Susan Q. , Potter Chloe , Sandell Lisa L. , Corbo Joseph C. , Palczewski Krzysztof , Maeda Akiko , Hodzic Didier , Kefalov Vladimir J.
Published: May 2017

Pigment regeneration is critical for the function of cone photoreceptors in bright and rapidly-changing light conditions. This process is facilitated by the recently-characterized retina visual cycle, in which Müller cells recycle spent all-trans-retinol visual chromophore back to 11-cis-retinol. This 11-cis-retinol is oxidized selectively in cones to the 11-cis-retinal used for pigment regeneration. However, the enzyme responsible for the oxidation of 11-cis-retinol remains unknown. Here, we sought to determine whether retinol dehydrogenase 10 (RDH10), upregulated in rod/cone hybrid retinas and expressed abundantly in Müller cells, is the enzyme that drives this reaction. We created mice lacking RDH10 either in cone photoreceptors, Müller cells, or the entire retina. In vivo electroretinography and transretinal recordings revealed normal cone photoresponses in all RDH10-deficient mouse lines. Notably, their cone-driven dark adaptation both in vivo and in isolated retina was unaffected, indicating that RDH10 is not required for the function of the retina visual cycle. We also generated transgenic mice expressing RDH10 ectopically in rod cells. However, rod dark adaptation was unaffected by the expression of RDH10 and transgenic rods were unable to use cis-retinol for pigment regeneration. We conclude that RDH10 is not the dominant retina 11-cis-RDH, leaving its primary function in the retina unknown.
Temporal dynamics of TMS interference over preparatory alpha activity during semantic decisions
Authors: Spadone Sara , Sestieri Carlo , Baldassarre Antonello , Capotosto Paolo
Published: May 2017

The mean amplitude of the EEG alpha (8–12 Hz) power de-synchronization (ERD) is a robust electrophysiological correlate of task anticipation. Furthermore, in paradigms using a fixed period between warning and target stimuli, such alpha de-synchronization tends to increase and to peak just before target presentation. Previous studies from our group showed that the anticipatory alpha ERD can be modulated when magnetic stimulation is delivered over specific cortical regions during a variety of cognitive tasks. In this study we investigate the temporal dynamics of the anticipatory alpha ERD and test whether the magnetic stimulation produces either a general attenuation or an interruption of the typical development of alpha ERD. We report that, during a semantic decision task, rTMS over left AG, a region previously associated to semantic memory retrieval, shortened the peak latency and decreased the peak amplitude of the anticipatory alpha de-synchronization as compared to both active (left IPS) and non-active (Sham) TMS conditions. These results, while supporting the causal role of the left AG in the anticipation of a semantic decision task, suggest that magnetic interference not simply reduces the mean amplitude of anticipatory alpha ERD but also interrupts its typical temporal evolution in paradigms employing fixed cue-target intervals.
A Second Mortuary Hiatus on Lake Baikal in Siberia and the Arrival of Small-Scale Pastoralism
Authors: Losey Robert J. , Waters-Rist Andrea L. , Nomokonova Tatiana , Kharinskii Artur A.
Published: May 2017

The spread of pastoralism in Asia is poorly understood, including how such processes affected northern forager populations. Lake Baikal’s western shore has a rich Holocene archaeological record that tracks these processes. The Early Bronze Age here is evidenced by numerous forager burials. The Early Iron Age (EIA) is thought to mark the arrival of pastoralists, but archaeological remains from this period have received little analysis. New radiocarbon dates for EIA human remains from 23 cemeteries indicate that no burials were created along this shore for ~900 years. This period, from ~3670 to 2760 cal. BP, spans from the end of the Early Bronze Age to the advent of the EIA. The burial gap may mark disruption of local foraging populations through incursions by non-local pastoralists. Radiocarbon dates on faunal remains indicate that domestic herd animals first appear around 3275 cal. BP, just prior to the first EIA human burials. Stable carbon and nitrogen isotope analysis of human remains and zooarchaeological data indicate that domestic fauna were minor dietary components for EIA people. Like preceding foragers, the EIA groups relied extensively on Baikal’s aquatic food sources, indicating that the scale of pastoralism during this period was relatively limited.
Salmonella produce microRNA-like RNA fragment Sal-1 in the infected cells to facilitate intracellular survival
Authors: Gu Hongwei , Zhao Chihao , Zhang Tianfu , Liang Hongwei , Wang Xiao-Ming , Pan Yi , Chen Xi , Zhao Quan , Li Donghai , Liu Fenyong , Zhang Chen-Yu , Zen Ke
Published: May 2017

Salmonella have developed a sophisticated machinery to evade immune clearance and promote survival in the infected cells. Previous studies were mostly focused on either bacteria itself or host cells, the interaction mechanism of host-pathogen awaits further exploration. In the present study, we show that Salmonella can exploit mammalian cell non-classical microRNA processing machinery to further process bacterial small non-coding RNAs into microRNA-like fragments. Sal-1, one such fragment with the highest copy number in the infected cells, is derived from Salmonella 5′-leader of the ribosomal RNA transcript and has a ‘stem’ structure-containing precursor. Processing of Sal-1 precursors to mature Sal-1 is dependent on host cell Argonaute 2 (AGO2) but not Dicer. Functionally, depleting cellular Sal-1 strongly renders the Salmonella bacteria less resistant to the host defenses both in vitro and in vivo. In conclusion, we demonstrate a novel strategy for Salmonella evading the host immune clearance, in which Salmonella produce microRNA-like functional RNA fragments to establish a microenvironment facilitating bacterial survival.
Enhanced photoelectrochemical response of plasmonic Au embedded BiVO4/Fe2O3 heterojunction
Authors: Verma Anuradha , Srivastav Anupam , Khan Saif A. , Rani Satsangi Vibha , Shrivastav Rohit , Kumar Avasthi Devesh , Dass Sahab
Published: May 2017

The effect of embedding Au nanoparticles (NPs) in a BiVO4/Fe2O3 heterojunction for photoelectrochemical water splitting is studied here for the first time.
Evolution of the structural, energetic, and electronic properties of the 3d, 4d, and 5d transition-metal clusters (30 TMn systems for n = 2–15): a density functional theory investigation
Authors: Chaves Anderson S. , Piotrowski Maurício J. , Da Silva Juarez L. F.
Published: May 2017

Subnanometric transition-metal (TM) clusters have attracted great attention due to their unexpected physical and chemical properties, leastwise compared to their bulk counterparts.
4N electron aromatic cycles in polycyclic hydrocarbons
Authors: Mauksch Michael , Tsogoeva Svetlana B.
Published: May 2017

Antiaromatic frameworks become aromatic in polycyclics through fusion, resulting in 4N electron hydrocarbons that possess aromatic properties by energetic, magnetic and geometric criteria.
Syntheses and catalytic oxotransfer activities of oxo molybdenum(vi) complexes of a new aminoalcohol phenolate ligand
Authors: Hossain M. K. , Haukka M. , Sillanpää R. , Hrovat D. A. , Richmond M. G. , Nordlander E. , Lehtonen A.
Published: May 2017

A novel trimeric complex [{MoO2(L)}3] (L = tridentate aminoalcohol phenolate ligand) produces monomeric solvent adducts [MoO2(L)(solv)] in coordinating solvents. All complexes have been investigated as catalysts in oxotransfer reactions.
Synthetic and structural studies of phosphine coordinated boronium salts
Authors: Hill Anthony F. , Ward Jas S.
Published: May 2017

The reactions of BrH2B·SMe2 or Br2HB·SMe2 with a variety of primary, secondary, tertiary and chelating phosphines affords a range of boronium salts of the form [HXB(PR3)2]Br (X = H, Br), e.g., the ferrocenophane shown. The equilibrium between such species and the neutral haloborane adducts HXBr(PR3) is discussed.
LaTiO2N–LaCrO3: continuous solid solutions towards enhanced photocatalytic H2 evolution under visible-light irradiation
Authors: Shi Jinwen , Zhang Yazhou , Zhou Zhaohui , Zhao Yixiang , Liu Jingyuan , Liu Hongbing , Liao Xiang , Hu Yuchao , Zhao Daming , Shen Shaohua
Published: May 2017

(LaTiO2N)1−x(LaCrO3)x continuous solid solutions were developed and showed enhanced photocatalytic H2-evolution activities under visible-light irradiation because of their narrowed bandgaps and increased lattice distortion.
A substituent effect of phenylacetic acid coligand perturbed structures and magnetic properties observed in two triple-bridged azido-Cu(ii) chain compounds with ferromagnetic ordering and slow magnetic relaxation
Authors: Liu Xiangyu , Ma Xiaohui , Cen Peipei , Wu Yuewei , Zhang Chengcheng , Shi Quan , Song Weiming , Xie Gang , Chen Sanping
Published: May 2017

Two triple-bridged azido-Cu(ii) chains exhibit distinct magnetic behaviors.
Paper microfluidics for nucleic acid amplification testing (NAAT) of infectious diseases
Authors: Magro Laura , Escadafal Camille , Garneret Pierre , Jacquelin Béatrice , Kwasiborski Aurélia , Manuguerra Jean-Claude , Monti Fabrice , Sakuntabhai Anavaj , Vanhomwegen Jessica , Lafaye Pierre , Tabeling Patrick
Published: May 2017

On-field infectious disease diagnostics can be performed with paper microfluidics through sample preparation and nucleic acid amplification.
Integrated pretreatment and desalination by electrocoagulation (EC)–ion concentration polarization (ICP) hybrid
Authors: Choi Siwon , Kim Bumjoo , Han Jongyoon
Published: May 2017

We integrated desalination and particle removal technologies into a single electrochemical system and demonstrated its operation on a microfluidic platform.
Pt–Co deposited on polyaniline-modified carbon for the electro-reduction of oxygen: the interaction between Pt–Co nanoparticles and polyaniline
Authors: Liu Yang , Chen Nanjun , Wang Fanghui , Cai Yezheng , Zhu Hong
Published: May 2017

PANI partially decomposed at 500 °C and metal–nitrogen bonds appeared in Pt–Co/C-PANI-500 °C, improving the ORR activity.
Tunable near-infrared fluorescent gold nanoclusters: temperature sensor and targeted bioimaging
Authors: Sun Yuanqing , Wu Jiapeng , Wang Chuanxi , Zhao Yueqi , Lin Quan
Published: May 2017

Tunable near-infrared fluorescent FA-conjugated GSH–AuNCs with thermosensitivity could be able to target HeLa cells.
Mechanism of Zn(OTf)2catalyzed hydroamination–hydrogenation of alkynes with amines: insight from theory
Authors: Nisa Riffat Un , Ayub Khurshid
Published: May 2017

Zn(OTf)2catalyzed hydroamination of alkynes with amines proceeds through an outer sphere mechanism which is contrary to other late transition metals.
Ligand effect on the synthesis of emission-tunable near-infrared Ag2S quantum dots
Authors: Jiang Peng , Chen Zilin
Published: May 2017

The ligand effect on the formation of Ag2S QDs was investigated, and it was found that the mixed oleic acid and 1-octanethiol ligand made the synthesis of small Ag2S QDs more controllable. By modulating the ligand composition and growth time, the emission of Ag2S QDs could be tuned from 665 to 845 nm.
Water-mediated and promoted eco-friendly one-pot synthesis of azaarene substituted isoxazoles
Authors: Nagaraju Dharavath , Rajanarendar Eligeti , Praveen Kumar Pittala , Nagi Reddy Modugu
Published: May 2017

An efficient and green approach for the sp3 C–H bond functionalization of 2-methyl azaarenes to 3-methyl-4-nitro-5-styrylisoxazoles in water has been described.
Application of primary halogenated hydrocarbons for the synthesis of 3-aryl and 3-alkyl indolizines
Authors: Liu Yan , Hu Huayou , Zhou Junyu , Wang Wenhui , He Youliang , Wang Chao
Published: May 2017

A transition-metal-free synthetic route to 3-aryl and 3-alkyl indolizines from electron-deficient alkenes, pyridines and primary halogenated hydrocarbons is reported for the first time using a tandem reaction.
AlCl3 catalyzed coupling of N-benzylic sulfonamides with 2-substituted cyanoacetates through carbon–nitrogen bond cleavage
Authors: Hu Chen , Hong Gang , Qian Xiaofei , Kim Kwang Rim , Zhu Xiaoyan , Wang Limin
Published: May 2017

A new cross-coupling reaction of N-benzylic sulfonamides with 2-substituted cyanoacetates for the synthesis of 2-substituted benzylbenzene was reported.
Catalytic enantioselective aza-Reformatsky reaction with seven-membered cyclic imines dibenzo[b,f][1,4]oxazepines
Authors: De Munck Lode , Sukowski Verena , Vila Carlos , Muñoz M. Carmen , Pedro José R.
Published: May 2017

A catalytic enantioselective aza-Reformatsky reaction with cyclic dibenzo[b,f][1,4]oxazepines and ethyl iodoacetate is reported.
Reduction of package-induced error for the composition analysis of in-package liquid products based on transmission spectrum
Authors: Zhang Shengzhao , Li Gang , Wang Jiexi , Wang Donggen , Han Ying , Liu Minxia , Lin Ling
Published: May 2017

The influence of packaging on the spectral analysis of in-package liquid products was studied in this work, and a method was proposed to formulate a calibration model to inhibit the effect of different absorptions of the package due to different thicknesses of the package.
Effective n-type F-doped MoSe2 monolayers
Authors: Zhao Xu , Zhang Xiaonan , Wang Tianxing , Wei Shuyi , Yang Lin
Published: May 2017

Using a first-principles method, based on the Vienna Ab-initio Simulation Package (VASP), we have studied the electronic structure, formation energy and transition level of a MoSe2 monolayer doped with V and VII atoms.
Enhanced efficiency of planar perovskite solar cells via a two-step deposition using DMF as an additive to optimize the crystal growth behavior
Authors: Mo Jiajie , Zhang Chunfu , Chang Jingjing , Yang Haifeng , Xi He , Chen Dazheng , Lin Zhenhua , Lu Gang , Zhang Jincheng , Hao Yue
Published: May 2017

We present a facile way towards the use of the polar solvent additive in the inter-diffusion two-step sequential deposition method for a high quality perovskite film.
Strategies of constructing stable and high sulfur loading cathodes based on the blade-casting technique
Authors: Zeng Fanglei , Wang Anbang , Wang Weikun , Jin Zhaoqing , Yang Yu-Sheng
Published: May 2017

In this work, a micro–nano-structured CS@CTAB/ABS + CNTS electrode with a high sulfur content of 76 wt% and a high sulfur mass loading of 6.7–11.1 mg cm−2 was constructed for application in Li–S batteries via the blade-casting technique, which could deliver a high areal capacity of 11.22 mA h cm−2.
Triethylene glycol-modified iridium(iii) complexes for fluorescence imaging of Schistosoma japonicum
Authors: Wu Yongquan , Zeng Guanjie , Lvyue Nannan , Wu Weihua , Jiang Tianyu , Wu Rongle , Guo Wei , Li Xun , Fan Xiaolin
Published: May 2017

Novel iridium(iii) complexes for fluorescence imaging of Schistosoma japonicum.
Zebrafish models for functional and toxicological screening of nanoscale drug delivery systems: promoting preclinical applications
Authors: Lee Keon Yong , Jang Gun Hyuk , Byun Cho Hyun , Jeun Minhong , Searson Peter C. , Lee Kwan Hyi
Published: May 2017

Preclinical screening with animal models is an important initial step in clinical translation of new drug delivery systems. However, establishing efficacy, biodistribution, and biotoxicity of complex, multicomponent systems in small animal models can be expensive and time-consuming. Zebrafish models represent an alternative for preclinical studies for nanoscale drug delivery systems. These models allow easy optical imaging, large sample size, and organ-specific studies, and hence an increasing number of preclinical studies are employing zebrafish models. In this review, we introduce various models and discuss recent studies of nanoscale drug delivery systems in zebrafish models. Also in the end, we proposed a guideline for the preclinical trials to accelerate the progress in this field.
Kidney, heart and brain: three organs targeted by ageing and glycation
Authors: Frimat Marie , Daroux Maité , Litke Rachel , Nevière Rémi , Tessier Frédéric J. , Boulanger Eric
Published: May 2017

Advanced glycation end-product (AGE) is the generic term for a heterogeneous group of derivatives arising from a non-enzymatic reaction between reducing sugars and proteins. In recent years, evidence has accumulated that incriminates AGEs in pathogenic processes associated with both chronic hyperglycaemia and age-related diseases. Regardless of their exogenous or endogenous origin, the accumulation of AGEs and their derivatives could promote accelerated ageing by leading to protein modifications and activating several inflammatory signalling pathways via AGE-specific receptors. However, it remains to be demonstrated whether preventing the accumulation of AGEs and their effects is an important therapeutic option for successful ageing. The present review gives an overview of the current knowledge on the pathogenic role of AGEs by focusing on three AGE target organs: kidney, heart and brain. For each of these organs we concentrate on an age-related disease, each of which is a major public health issue: chronic kidney disease, heart dysfunction and neurodegenerative diseases. Even though strong connections have been highlighted between glycation and age-related pathogenesis, causal links still need to be validated. In each case, we report evidence and uncertainties suggested by animal or epidemiological studies on the possible link between pathogenesis and glycation in a chronic hyperglycaemic state, in the absence of diabetes, and with exogenous AGEs alone. Finally, we present some promising anti-AGE strategies that are currently being studied.
Effect of Electrode Montage and Head Position on Air-Conducted Ocular Vestibular Evoked Myogenic Potential
Authors: Makowiec Kathryn , McCaslin Devin L. , Jacobson Gary P. , Hatton Kelsey , Lee John
Published: May 2017

Purpose

The purpose of this investigation was to identify the optimal recording parameters for evoking the ocular vestibular evoked myogenic potential (oVEMP) using air-conduction stimuli.

Method

Subjects were 17 otologically and neurologically intact adults (age:
M
= 24.18 years,
SD
= 1.91 years). The oVEMP responses were elicited using a 500-Hz tone burst air-conduction stimulus presented at an intensity of 95 dB nHL. The setting was a balance function laboratory that was part of a large tertiary care otology clinic.

Results

The oVEMP electrode montage and body position that yielded the largest oVEMP amplitude was the belly-tendon montage (Sandhu, George, & Rea, 2013), recorded with the subject in the sitting position. The N1 latency recorded with the belly-tendon montage was significantly shorter than that recorded for the infraorbital montage in both the sitting and supine positions.

Conclusion

The belly-tendon recording montage with the subject sitting yields significantly larger oVEMP amplitudes and shorter N1 latencies than do traditional bipolar infraorbital recordings.
Towards controller placement problem for software‐defined network using affinity propagation
Authors: Zhao Jianlong , Qu Hua , Zhao Jihong , Luan Zhirong , Guo Ya
Published: May 2017

This Letter investigates multi‐controller placement problem for software‐defined network aiming at minimising the propagation latency between switches and associated controllers. Distinct from the standard clustering‐based partition approaches, a modified exemplar‐based clustering method based on affinity propagation is presented to address the problem. Instead of specifying beforehand the number and locations of controllers, this method can learn the optimal number and locations of controllers adaptively according to network topology. Extensive simulation results demonstrate that the proposed method can provide more stable and accurate controller placement results in terms of latency minimisation compared with k‐median and k‐centre methods.
Wideband excitation technology of substrate integrated waveguide TE30 mode and its antenna application
Authors: Sun Lubing , Zhang Yongsong , Cai Yang , Qian Zuping
Published: May 2017

An excitation technology of TE30 mode in substrate integrated waveguide (SIW) and its application for designing a compact Yagi–Uda antenna array is proposed. Coplanar waveguide (CPW) structure is adopted as the input and two slots of CPW are further extended in the SIW along the third lines in the longitudinal direction to convert the electromagnetic field pattern between the slot and SIW. Therefore, TE30 mode is successfully excited. A Yagi–Uda antenna array fed by the SIW operating at TE30 mode is fabricated and measured. A broad impedance bandwidth of 46% (|S11| < −10 dB) ranging from 7.8 to 12.4 GHz is achieved with obtaining a maximum gain of 8.5 dBi. Compared with the traditional SIW antenna array based on TE10 mode, the higher mode excitation technology not only simplifies the feeding network but also reduces the difficulty of processing.
On the improvement of foreground–background model‐based object tracker
Authors: Hanif Muhammad Shehzad , Ahmad Shafiq , Khurshid Khurram
Published: May 2017

In this study, the authors propose two kinds of improvements to a baseline tracker that employs the tracking‐by‐detection framework. First, they explore different feature spaces by employing features commonly used in object detection to improve the performance of detector in feature space. Second, they propose a robust scale estimation algorithm that estimates the size of the object in the current frame. Their experimental results on the challenging online tracking benchmark‐13 dataset show that reduced dimensionality histogram of oriented gradients boosts the performance of the tracker. The proposed scale estimation algorithm provides a significant gain and reduces the failure of the tracker in challenging scenarios. The improved tracker is compared with 13 state‐of‐the‐art trackers. The quantitative and qualitative results show that the performance of the tracker is comparable with the state of the art against initialisation errors, variations in illumination, scale and motion, out‐of‐plane and in‐plane rotations, deformations and low resolution.
Forecasting degradation rates of different photovoltaic systems using robust principal component analysis and ARIMA
Authors: Pieri Elena , Kyprianou Andreas , Phinikarides Alexander , Makrides George , Georghiou George E.
Published: May 2017

Degradation rates based on forecasting of performance ratio, , time series are computed and compared with actual degradation rates. A 3‐year forecasting of monthly , measured from photovoltaic (PV) connected systems of various technologies is performed using the seasonal auto‐regressive integrating moving average (ARIMA) time series model. The seasonal ARIMA model is estimated using monthly measured over a 5‐year period and based on this model forecasting is implemented for the subsequent 3 years. The degradation rate at the end of the forecasting period, eighth year, is computed using a robust principal component analysis based methodology. The degradation rates obtained for various (PV) systems are then compared with the ones obtained using the actual 8‐year data.
Solvothermal synthesis of sub‐200 nm Fe3O4 submicrospheres with enhanced catalytic performances by using acicular goethite as solid precursor
Authors: Chen Wu , Xiong Leisha , Chen Fengxi
Published: May 2017

A facile and low‐cost chemical method is still in need to make Fe3O4 submicrospheres with the size below 200 nm. In this study, Fe3O4 submicrospheres of ca. 173 nm with soft‐magnetic properties were made by conversion of goethite under solvothermal conditions, and exhibited the good catalytic activity and reusability for selective oxidation of benzyl alcohol to benzaldehyde with H2O2 in water (yield: 43.5–46.2% after being recycled seven times).
Single-machine batch scheduling problem with job rejection and resource dependent processing times
Authors: Huang Weifan , Wu Chin-Chia , Liu Shangchia
Published: May 2017

This paper addresses single-machine batch scheduling with job rejection and convex resource allocation. A job is either rejected, in which case a rejection penalty will be incurred, or accepted and processed on the machine. The accepted jobs are combined to form batches containing contiguously scheduled jobs. For each batch, a batch-dependent machine setup time, which is a function of the number of batches processed previously, is required before the first job in the batch is processed. Both the setup times and job processing times are controllable by allocating a continuously divisible nonrenewable resource to the jobs. The objective is to determine an accepted job sequence, a rejected job set, a partition of the accepted job sequence into batches, and resource allocation that jointly minimize a cost function based on the total delivery dates of the accepted jobs, and the job holding, resource consumption, and rejection penalties. An dynamic programming solution algorithm with running time O (n6) is developed for the problem. It is also shown that the case of the problem with a common setup time can be solved in O (n5) time.
Highly Regio- and Diastereoselective [3+2]-Annulation Reaction of Morita–Baylis–Hillman Carbonates with Pyrazolones Catalyzed by Tertiary Phosphines
Authors: Miao Zhiwei , Zheng Weiping , Li Yuming , Zhang Jiayong , Du Siyi
Published: May 2017

A phosphine-catalyzed [3+2] annulation between N-phenylpyrazolone derivatives and Morita–Baylis–Hillman carbonates for the synthesis of chiral heterocyclic systems containing spiro[cyclopentane-3,3′-pyrazole] scaffolds has been developed. The reaction afforded the desired products in moderate to high yields (up to 97%) with good to excellent diastereoselectivities (up to 20:1). A plausible reaction mechanism has also been proposed based on previous literature.
Surgical Treatment of Posttraumatic Laterognathia: A Case Report and a Literature Review, Focused on the Effects of a Condylar Fracture on the Face
Authors: Pereira Felipe Ladeira , de Marilac de Alencar Pinheiro Luísa , Araújo Phelype Maia , Chihara LetíciaLiana , Maia Nogueira Renato Luiz , Sant'Ana Eduardo
Published: May 2017

Facial asymmetry, following early childhood condylar trauma, is a common complaint among patients who seek surgical treatment. G.D.M., a 27-year-old male patient, sought professional help to correct his cosmetic flaw, caused by a condylar fracture when he was 8-years-old. After the proper orthodontic treatment, he underwent a double jaw orthognathic surgery and, 9 months later, a second one to correct the remaining asymmetry. Two years after this second procedure, the patient is still under surveillance and has no complaints.
Vereinbarkeit von Familie und Beruf bei Beschäftigten im Gesundheitswesen als Handlungsfeld der Versorgungsforschung
Authors: Lukasczik Matthias , Ahnert Jutta , Ströbl Veronika , Vogel Heiner , Donath Carolin , Enger Ilka , Gräßel Elmar , Heyelmann Lena , Lux Heidemarie , Maurer Jochen , Özbe Dominik , Spieckenbaum Stefanie , Voigtländer Elzbieta , Wildner Manfred , Zapf Andreas , Zellner Angela , Hollederer Alfons
Published: May 2017

Hintergrund/Ziele Beschäftigte im Gesundheitswesen sind mit besonderen beruflichen Rahmenbedingungen und Anforderungen konfrontiert, die sich auf das Verhältnis von Familie und Arbeit/Beruf auswirken können und mittelbar auch die Qualität der Gesundheitsversorgung beeinflussen. Ziel des vorliegenden Beitrags ist es, einen Überblick über den Forschungsstand zu diesem Thema zu geben. Dieser ist für die Versorgungsforschung von Relevanz. Er kann als Ausgangspunkt dafür dienen, Strukturen im Gesundheitswesen (auch in ländlichen Regionen) dahingehend zu verändern, dass sie eine bessere Vereinbarkeit von Familie und Beruf ermöglichen.

Methode Es wurde eine systematische nationale und internationale Literaturrecherche in Form eines Scoping Review durchgeführt, um den aktuellen Forschungsstand zur Vereinbarkeit von Familie und Gesundheitsberuf zu dokumentieren. Als inhaltliche Suchkriterien wurden definiert: Vereinbarkeit von Beruf und Familie (allgemein); Vereinbarkeitserleben und -konflikte bei Gesundheitsberufen; Vereinbarkeit von Familie und Gesundheitsberuf im ländlichen Raum; Interventionsansätze zur Förderung der Vereinbarkeit von Beruf und Familie. Im Ergebnis eines mehrstufigen Selektionsprozesses wurden 145 Publikationen in die inhaltliche Auswertung einbezogen.

Ergebnisse Die dokumentierte Literatur bezieht sich schwerpunktmäßig auf die Berufsgruppen Ärzte und beruflich Pflegende, für andere Berufsgruppen liegen kaum Arbeiten vor. Die methodische Qualität der Studien ist meist niedrig, Metaanalysen liegen nicht vor. Mehrere Arbeiten dokumentieren eine Unzufriedenheit bei Ärzten und beruflich Pflegenden bzgl. Möglichkeiten der Vereinbarkeit von Familie und Beruf. Es konnten nur wenige Interventionsstudien zur Förderung der Vereinbarkeit von Familie und Beruf gefunden werden, diese sind wiederum nur teilweise spezifisch auf Gesundheitsberufe ausgerichtet. Defizite bestehen zudem hinsichtlich der Vernetzung mit Fragen der Verbesserung der Gesundheitsversorgung in ländlichen Gebieten.

Schlussfolgerung Zur Thematik „Vereinbarkeit von Familie und Gesundheitsberuf“ existiert national wie international nur wenig systematische Forschung. Insbesondere zur Evaluation von Maßnahmen bestehen Defizite. Der Literaturüberblick ermöglicht die Ableitung von Ansatzpunkten, um eine Verbesserung der Vereinbarkeit von Familie und Beruf zu erreichen.
A Genetic Marker Associated with Shoulder Dislocation
Authors: Kim Stuart , Kleimeyer John , Ahmed Marwa , Avins Andy , Fredericson Michael , Dragoo Jason , Ioannidis John
Published: May 2017

Shoulder dislocations are common shoulder injuries associated with athletic activity in contact sports, such as football, rugby, wrestling, and hockey. Identifying genetic loci associated with shoulder dislocation could shed light on underlying mechanisms for injury and identify predictive genetic markers. To identify DNA polymorphisms associated with shoulder dislocation, a genome-wide association screen was performed using publically available data from the Research Program in Genes, Environment and Health including 662 cases of shoulder dislocation and 82 602 controls from the European ancestry group. rs12913965 showed an association with shoulder dislocation at genome-wide significance (p=9.7×10−9; odds ratio=1.6) from the European ancestry group. Individuals carrying one copy of the risk allele (T) at rs12913965 showed a 69% increased risk for shoulder dislocation in our cohort. rs12913965 is located within an intron of the TICRR gene, which encodes TOPBP1 interacting checkpoint and replication regulator involved in the cell cycle. rs12913965 is also associated with changes in expression of the ISG20 gene, which encodes an antiviral nuclease induced by interferons. This genetic marker may one day be used to identify athletes with a higher genetic risk for shoulder dislocation. It will be important to replicate this finding in future studies.
Koinzidenz und Therapie von Beinachsdeviationen bei degenerativen Knorpelschäden des Kniegelenks. Ergebnisse aus dem Deutschen KnorpelRegister DGOU
Authors: Spahn Gunter , Fritz Jürgen , Albrecht Dirk , Angele Peter , Fickert Stefan , Aurich Matthias , Hofmann Gunther , Niemeyer Phillip
Published: May 2017

Zielsetzung Ziel dieser arthroskopischen Multicenterstudie war es, die Koinzidenz von degenerativ bedingten Knorpelschäden mit Varus- oder Valgusfehlstellungen zu bestimmen. Weiterhin war es Ziel, die Häufigkeit von die knorpelregenerativen Eingriffe begleitenden Korrekturoperationen von Varus- oder Valgusfehlstellungen in der deutschen Versorgungsrealität zu ermitteln.

Material und Methode Von insgesamt 1778 Patienten, die zum Stichtag 01.08.2016 im Deutschen KnorpelRegister registriert waren, wurde in 90,9% der Fälle die Beinachse durch den Operateur klinisch und in 56,0% der Fälle durch eine radiologische Messung bestimmt. In die Auswertung wurden insgesamt 614 Patienten mit einem fokalen degenerativ bedingten Knorpelschaden aufgenommen, bei denen präoperativ sowohl eine klinische als auch eine radiologische Beinachsendiagnostik erfolgt war.

Ergebnisse Der durchschnittliche mechanische Tibia-Femur-Winkel nach Paley (mTFA) betrug bei klinisch neutraler Beinachse 0,2° (SD 0,6; 0 – 5), bei klinischem Varus 5,0° (SD 3,2; 0 – 15) und bei klinischem Valgus − 4,7° (SD − 4,0; − 15 – 0). Damit hatten 76,9% der Patienten eine normale Beinachse. Ein Varus wurde in 18,9% und ein Valgus in 4,2% der Fälle bestimmt. Varusfehlstellungen waren häufiger mit Knorpelschäden im medialen und Valgusfehlstellungen häufiger mit Schäden im Bereich des lateralen Kompartiments assoziiert. In 72,4% wurde bei vorliegendem Varus der Knorpeleingriff mit einem zeitnahen Korrektureingriff der Beinachse kombiniert. Beim Vorliegen einer Valgusfehlstellung wurde dies in der Hälfte der Fälle vorgenommen. Auf die Entscheidung des Operateurs zur gleichzeitigen Achskorrektur hatte die Wahl des knorpelregenerativen Verfahrens keinen Einfluss.

Schlussfolgerungen Degenerative Knorpelschäden im Bereich des Kniegelenks sind in etwa einem Viertel der Fälle mit pathologischen Abweichungen der Beinachse (18,9% Varus; 4,2% Valgus) assoziiert. In einem hohen Prozentsatz solcher Fehlstellungen werden durch die Operateure zusätzlich zum knorpelregenerativen Eingriff zeitnah Korrektureingriffe vorgenommen. Dabei ist jedoch bislang unklar, inwieweit dies die Prognose und das Ergebnis beeinflusst.
Salvia plebeia Extract Inhibits Xanthine Oxidase Activity In Vitro and Reduces Serum Uric Acid in an Animal Model of Hyperuricemia
Authors: Kim Jin , Kim Woo , Hyun Jung , Lee Jong , Kwon Jin , Seo Changon , Song Myung-Jin , Choi Chun , Hong Seong , Park Kyuhee , Kim Pansoo , Sung Hachang , Lee Jin , Choi Yongmun
Published: May 2017

Hyperuricemia is a clinical condition characterized by an elevated level of serum uric acid and is a key risk factor for the development of gout and metabolic disorders. The existing urate-lowering therapies are often impractical for certain patient populations, providing a rationale to explore new agents with improved safety and efficacy. Here, we discovered that Salvia plebeia extract inhibited the enzyme activity of xanthine oxidase, which is a key enzyme generating uric acid in the liver. In an animal model of hyperuricemia, S. plebeia extract reduced serum urate to the levels observed in control animals. The urate-lowering effect of S. plebeia extract in vivo was supported by the identification of compounds that inhibit xanthine oxidase enzyme activity in vitro. Nepetin, scutellarein, and luteolin contributed significantly to S. plebeia bioactivity in vitro. These compounds showed the highest potency against xanthine oxidase with IC50 values of 2.35, 1.74, and 1.90 µM, respectively, and were present at moderate quantities. These observations serve as a basis for further elaboration of the S. plebeia extracts for the development of new therapeutics for hyperuricemia and related diseases.
A numerical and theoretical study on viscoelastic fluid slip flows
Authors: Ferrás L. L. , Afonso A. M. , Nóbrega J. M. , Pinho F. T.
Published: May 2017

This work describes a theoretical and numerical investigation of viscoelastic fluid flows, considering slip boundary conditions. The viscoelastic fluid is described by the simplified Phan-Thien-Tanner model, and the governing equations with slip boundary conditions are solved by a finite volume method using (1) a recently proposed methodology to control the growth of the slip velocity along the iterative process (named the SIMPLE-slip method) where some simplifications are assumed at the wall, and also (2) a slip formulation where the complete stress tensor at the wall is taken into account. Analytical and semi-analytical solutions are also provided for the fully developed flow between parallel plates of viscoelastic fluids, assuming Thomson and Troian and Lau and Schowalter non-linear wall slip models. For verification purposes, the numerical results were compared with the analytical solution for fully developed slip-flow in a planar channel using two non-linear slip models. Simulations were carried out in a classical benchmark problem in computational rheology, the viscoelastic fluid flow in a slip-stick geometry, aiming to identify the influence of slip intensity on the flow patterns, velocity, and stress growth at the singularity region.
Density functional study of structure and dynamics in liquid antimony and Sbn clusters
Authors: Jones R. O. , Ahlstedt O. , Akola J. , Ropo M.
Published: May 2017

Density functional/molecular dynamics simulations have been performed on liquid antimony (588 atoms and six temperatures between 600 K and 1300 K) and on neutral Sb clusters with up to 14 atoms. We study structural patterns (coordination numbers, bond angles, and ring patterns, structure factors, pair distribution functions) and dynamical properties (vibration frequencies, diffusion constants, power spectra, dynamical structure factors, viscosity) and compare with available experimental results and with the results of our previous simulations on Bi. Three short covalent bonds characteristic of pnictogens are common in the clusters, and higher temperatures lead in the liquid to broader bond angle distributions, larger total cavity volumes, and weaker correlations between neighboring bond lengths. There are clear similarities between the properties of Sb and Bi aggregates.
Correlated matrix-fluctuation-mediated activated transport of dilute penetrants in glass-forming liquids and suspensions
Authors: Zhang Rui , Schweizer Kenneth S.
Published: May 2017

We formulate a microscopic, force-level statistical mechanical theory for the activated diffusion of dilute penetrants in dense liquids, colloidal suspensions, and glasses. The approach explicitly and self-consistently accounts for coupling between penetrant hopping and matrix dynamic displacements that actively facilitate the hopping event. The key new ideas involve two mechanistically (at a stochastic trajectory level) coupled dynamic free energy functions for the matrix and spherical penetrant particles. A single dynamic coupling parameter quantifies how much the matrix displaces relative to the penetrant when the latter reaches its transition state which is determined via the enforcement of a temporal causality or coincidence condition. The theory is implemented for dilute penetrants smaller than the matrix particles, with or without penetrant-matrix attractive forces. Model calculations reveal a rich dependence of the penetrant diffusion constant and degree of dynamic coupling on size ratio, volume fraction, and attraction strength. In the absence of attractions, a near exponential decrease of penetrant diffusivity with size ratio over an intermediate range is predicted, in contrast to the much steeper, non-exponential variation if one assumes local matrix dynamical fluctuations are not correlated with penetrant motion. For sticky penetrants, the relative and absolute influence of caging versus physical bond formation is studied. The conditions for a dynamic crossover from the case where a time scale separation between penetrant and matrix activated hopping exists to a “slaved” or “constraint release” fully coupled regime are determined. The particle mixture model is mapped to treat experimental thermal systems and applied to make predictions for the diffusivity of water, toluene, methanol, and oxygen in polyvinylacetate liquids and glasses. The theory agrees well with experiment with values of the penetrant-matrix size ratio close to their chemically intuitive values.
Conductivity tensor for anisotropic plasma in gyrokinetic theory
Authors: Porazik Peter , Johnson Jay R.
Published: May 2017

It has been argued that oblique firehose and mirror instabilities are important candidates for the regulation of temperature anisotropy in solar wind. To quantify the role of anisotropy driven instabilities, global kinetic simulations of the solar wind would be extremely useful. However, due to long time scales involved, such simulations are prohibitively expensive. Gyrokinetic theory and simulations have proven to be valuable tools for the study of low frequency phenomena in nonuniform plasmas; however, there are discrepancies between the anisotropy driven instabilities appearing in the gyrokinetic theory and those of a fully kinetic one. We present a derivation of the conductivity tensor based on the arbitrary frequency gyrokinetics and show that relaxing the condition ω/Ω≪1, where ω is the wave frequency, and the Ω is the cyclotron frequency, eliminates these discrepancies, while preserving the advantages of the gyorkinetic theory for global kinetic simulations.