bluuebunny/crossref_metadata_2025 huggingface dataset:
Solitary Choroid Plexus Metastasis of Clear Cell Renal Carcinoma 11years after nephrectomy : A case report
Authors: Trifa Amine , Benhaddou Lyna , Parker Fabrice
Published: November 2021

Brain metastasis are the most commun intracranial tumours amongst adults. While brain metastasis of Renal cell carcinoma (RCC) are less commun, intraventricular localisation is particularly rare. There are few small series and mostly case reports which have noted intraventricular involvement of RCC metastasis. Here we report a new case of Solitary choroid plexus metastasis of clear cell renal carcinoma 11 years after nephrectomy.It’s about a 51-year-old patient, diagnosed with renal tumor in 2010 and a nephrectomy was performed. He presented with a frontal syndrome consecutive to a left frontal intraventricular tumor with ipsilateral ventricular dilation. He was operated on for a complete excision of this tumor. Histopathological examinations revealed a metastasis of clear cell renal carcinoma. He underwent 3 radiosurgery sessions one month later. At 6 months of follow-up, he has described an important clinical improvement, mainly of his frontal syndrome.BM secondary to RCC tend to be located in the ventricular system with close association to the choroid plexus. Early detection of brain metastases, and a therapeutic strategy including surgery and radiosurgery can offer patients an extended survival.
Protection offered by COVID-19 vaccines in reducing SARS-CoV-2 infection frequency; severity and mortality, among Indian Healthcare Workers: Multicenter, pan-Fortis study
Authors: Acharya Subrat , Mahindra Gaurav , Nirala Purushottam , Tripathi Sulabh , Panigrahi Bishnu , Misra Anoop , Pandit Rahul , Goel Manoj , Chowdhury S. R. , Sircar Mrinal , Maurya Vikas , Jha R. S. , Kumar Avi , Mandal Amit K. , Micu Padmakumar , Gupta Ayush , Aithal Nagaraj , Queen Edel , Baghel Paritosh
Published: November 2021

During COVID-19 pandemic, Healthcare Workers (HCWs) were at increased risk for exposure to SARS-CoV-2 virus and prioritized for early administration of COVID-19 vaccines in India. Real-life scenario information among vaccinated HCWs acquiring COVID-19 infection, is scarce. We retrospectively analyzed COVID-19 infection frequency, severity, and associated mortality among healthcare workers, immunized with either Covishield or Covaxin vaccines at 27 Fortis Hospitals across 11 Indian states. Positive cases were identified based on RT-PCR or rapid antigen tests for SARS-CoV-2 between 16th January 2021 till 15th May 2021. 20034 HCWs received vaccination. 3971 received 1 dose, 16063 received 2 doses. Post-vaccination, 1139 HCWs acquired COVID-19 infection, 180 (4.53%) and 959 (5.97%) among partially and fully vaccinated category, respectively. Breakthrough infection occurred among 913 (5.68%) HCWs. Concurrently, Case Positivity Rate was 11.9%, among general population (control). Among 1139 positive cases, mild, moderate, and severe infections were 1059 (93%), 71 (6.2%) and 9 (0.8%), respectively with Case Fatality Rate of 0.18%, compared to 0.92% among general population (p=0.0043). The Case Fatality Rate in vaccinated HCWs was found to be 80% less than that in general population (control). Hence, COVID-19 vaccines available in India seem to be effective against SARS-CoV-2 virus.
Determinants of Anemia Among Pregnant Women Attending Antenatal Care in Bale-Robe Town Health Facilities, Bale zone, Southeast Ethiopia: A Case-Control Study
Authors: Badeso Mohammed Hasen , Kalili Falaho Sani , Abdulle Mohammed Seid
Published: November 2021

IntroductionIn Ethiopia, the prevalence of anemia in pregnant women differs geographically and ranged from 15.8–56.8%. The objective of this study is to identify the determinants of anemia among pregnant women attending antenatal care in health facilities of Bale-Robe Town, Southeast Ethiopia.MethodsA facility-based case-control study was conducted in Bale-Robe hospital and Baha-biftu health center in Bale-Robe, Southeast Ethiopia. A total of 282 pregnant women participated in the study (141 cases and 141 controls). Cases were pregnant women with altitude-adjusted hemoglobin value < 11.0 g/dl at the first and third trimesters, and < 10.5 g/dl at the second trimester. Controls were pregnant women with hemoglobin value ≥ 11.0 g/dl at first and third trimesters and ≥ 10.5 g/dl at the second trimester. A structured and pretested questionnaire was used to collect data. A multivariable logistic regression analysis was applied to assess the determinants of anemia. Determinants were categorized as sociodemographic and economic, obstetric and medical, and dietary intake and behavioral.ResultsHousewife occupation (AOR=2.1, 95% CI=1.12-3.92), prolonged menstrual bleeding (AOR=2.33, 95% CI=1.38-3.92) and undernutrition (AOR=4.03, 95% CI=1.38-11.83) were factors significantly associated with anemia in pregnant women.ConclusionHousewife occupation, prolonged menstrual bleeding, and malnutrition were the determinants of anemia in pregnant women. Hence, anemia prevention and control strategy in pregnant women should include adequate dietary intake, and strengthening nutritional counseling for pregnant women during antenatal care is also required by the health care provider.
RETRACTED: New Criterion for Shutter Designing by Dry Pluviation Method
Authors: Cheshomi Akbar - , Sadeghi Ali , Zadeh
Published: November 2021

The authors have requested that this preprint be removed from Research Square.
Mesoscopic collective dynamics in liquids and the Dual Model
Authors: Peluso Fabio
Published: November 2021

In the present article it is shown how a series of experimental evidences and theoretical developments on liquid modelling, gathered for the first time, can all be framed in a mesoscopic view of liquids that are hypothesized as constituted by a population of wave packets, responsible for the propagation of elastic and thermal perturbations, and of dynamic aggregates of molecules, in continuous re-arrangement, diving in an ocean of amorphous, disordered liquid. This model, dubbed Dual Model of Liquids (DML), is complementary to the Phonon theory of Liquid Thermodynamics (PLT), recently proposed by an independent group. The pseudo-crystalline dynamic structures, evidenced by high energy inelastic scattering experiments, interact with a statistical population of harmonic elastic waves and anharmonic wave-packets propagating within and among the structures themselves, respectively. The expression for the interaction term is derived from “first principles” based on general considerations related to the pressure exerted by elastic waves travelling in condensed media. The anharmonic character of the interaction allows the exchange not only of energy but also of momentum between wave packets and clusters, thus determining both the displacement of the latter within the medium, and the redistribution of the energy between external, or translatory degrees of freedom of the clusters, and internal collective, vibratory degrees. Using these concepts it is possible to calculate some dynamic and thermodynamic quantities concerning the dynamics of liquids. Moreover, the interpretation of the relaxation times of the processes involved in momentum and energy transport is given, their Order-of-Magnitude is calculated, and the way in which these times are involved in the different phases of the collective dynamics of liquids is discussed. A comparison is provided with results obtained in the frame of PLT and with the forecasts for the visco-elastic transition regions, in particular with systems exhibiting k-gap.In the last part of the paper, theoretical developments and experiments are suggested that should be performed to provide additional details to the model.
A Correlation Study of Sustainable Development Goal (SDG) Interactions
Authors: pakkan sheeba , Sudhakar Christopher , Tripathi Shubham , Rao Mahabaleshwara
Published: November 2021

As universities are the change agent of society, institutions from all nations set their goals to transform the world by exploring various societal challenges that humans are facing. Together, the higher education systems across the world developing strategies based on the United Nations’ Sustainable Development Goals (SDGs). This paper assesses the influence of 16 SDGs on each other paving the way for the universities to set a clear goal in attaining Sustainable Development goals by 2030. To analyze the SDGs interactions towards each other, 201844 research publications from India during five years on 16 SDGs are retrieved from the Scopus database. Spearman Rank Correlation is applied to understand the contribution of each SDG towards one another. We could observe converging results out of the interactions among the SDGs. A significant positive and moderately positive correlation between pairs of SDGs are identified. While a significant number of negative correlation is also classified which need deep thinking among researchers to make it positively correlated. The most frequent interactions between SDGs is a positive sign to any university in strategising the goal towards SDGs. The association of all university stakeholders and some constitutional and cultural changes are necessary to put SDGs at the core of the management of the university. Embracing this task by researchers will improve the overall performance of universities.
Cold Start Aware Hybrid Recommender System Approach for E-Commerce Users
Authors: Patro S Gopal Krishna , Mishra Brojo Kishore , Panda Sanjaya Kumar , Kumar Raghvendra , Long Hoang Viet , Taniar David
Published: November 2021

Collaborative Filtering (CF) schemes are very popular in Recommender System (RS) and offer specialized suggestions to users in e-commerce and social websites. But, they suffer from the Cold Start Problem (CSP) that occurs due to the lack of sufficient information about the new customers, purchase history, and browsing data. Moreover, data sparsity problems may arise when the interaction is made among a limited amount of items. This not only poses a negative impact on recommendation but also significantly condenses the diversity of choices available in the particular platform. To tackle these issues, a novel methodological approach called Sparsity and Cold Start Aware Hybrid Recommended System (SCSHRS) is designed to suppress data sparsity and CSP in RS. The proposed SCSHRS methodology comprises four stages. At the initial stage, the data sparsity is reduced and at stage 2, the similar users are grouped by Ant-Lion based k-means clustering. At stage 3, Higher-Order Singular Value Decomposition (HOSVD) method decomposes the data to a lesser dimension. At the final stage, the Adaptive Neuro-Fuzzy Inference System (ANFIS) uses IF-THEN rules and machine learning abilities to predict the output. The performance of the proposed SCSHRS method is tested on MovieLens-20M, Last. FM, and Book-Crossing datasets and compared with the prevailing techniques. Based on the evaluation report, the proposed SCSHRS system gives Mean Absolute Percentage Error (MAPE) of 40%, and, precision (0.16), recall (0.08), F-measure (0.1), and Normalized Discounted Cumulative Gain (NDCD) of 0.65. Hence, SCSHRS is proved to be a more efficient means of recommendation against cold start and sparsity problems.
Identification and Characterization of a Novel Potyvirus Infecting Paris Yunnanensis
Authors: Lan Pingxiu , He Peng , Cao Mengji , Zhou Guohua , Li Chenrong , Tan Guanlin , Chen Xiaojiao , Yang Jie , Wei Taiyun , Li Fan
Published: November 2021

The complete genomic sequence of a novel potyvirus from Paris yunnanensis was determined by high-throughput sequencing then confirmed by Sanger sequencing. Its genomic RNA consists 9600 nucleotides (nt) excluding the 3’-terminal poly (A) tail, containing a typical large open reading frame (ORF) of potyviruses and encoding a putative polyprotein of 3098 amino acids (aa). Pairwise comparison analysis showed the virus shares sequence identity with other members of Potyvirus was 53.0% to 57.8% at genome sequence level, and 39.3% to 51.2% at polyprotein sequence level. Phylogenetic analysis indicated that the virus was most closely related to the subgroup of plum pox virus and that of chilli veinal mottle virus within the genus Potyvirus. These results suggest that the virus should be considered as a distinct species within the genus Potyvirus and was tentatively named as “Paris mottle associated virus” (PMaV).
Designing Multi-Layer Security Using Chaotic Map in Cloud Environment
Authors: Rezaei Azita , Broumandnia Ali , Mirabedini Seyed Javad
Published: November 2021

Security level is a major subject that is considered rapidly. Major solution is focus on fault prevention against attacks. Many applications are monitored by fault tolerance. This implies clients have intend to tailor their application in special environment. This paper introduces an innovative on creating and managing security level that leads to boost service provider’s confidence and user satisfaction. This method allows user to specify and apply their security layer without requiring any knowledge about its implementation with SLA. This study proposes a multi- layer security that includes four main steps: Data Segmentation, Making Fake Services, Heuristic chaotic mapping and private key (PK) segment and Cryptography Code. PK is performed by chaotic maps and broker uses MQTT framework to facilitate security parameters. Experimental results show that the solution can balance the performance and security ranking and the propose scheme demonstrate security penalty cost is descended by 77%; the total penalty cost is decreased by 61.41% and the user satisfaction is grown by 60.67%. As a result, it ascends demanding and performance in cloud computing, compared with exiting approaches in encryption theories.
Consumption and Impacts of Water-Borne Polypropylene Microplastics on Daphnia Similis
Authors: Jeyavani Jeyaraj , Sibiya Ashokkumar , Gopi Narayanan , Mahboob Shahid , Al-Ghanim Khalid A. , Al-Misned Fahad A. M. , Ahmed Zubair , Riaz Mian Nadeem , Palaniappa Balasubramanian , Govindarajan Marimuthu , Vaseeharan Baskaralingam
Published: November 2021

Polypropylene microplastics are the primary pollutant in aquatic ecosystems and their toxicity assessment study remains limited. The proposed study focuses on acute exposure of polypropylene microplastic in Daphnia similis, which alters the biochemical parameter due to the accumulation of microplastics in the digestive tract. Moreover, the commercially available polypropylene bags have been converted into microplastic using xylene. FTIR results showed the absence of xylene residue in prepared microplastics particles and it was spherical shaped, size range (FE-SEM) from 11.86µm – 44.62µm. The outcome of the impact reveals that acute exposure to polypropylene microplastic in D. similis leads to immobilization. Further, the biochemical results showed that ingestion of microplastics increases reactive oxygen species (ROS) production. This leads to an increase in the antioxidant enzymes of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and a non-antioxidant enzyme of reduced glutathione (GSH) and also oxidative stress effects in lipid (lipid peroxidation - LPO), protein (Carbonyl protein - CP) gradually increases due to production of free radicals in D. similis. In addition, the neurotransmitter enzyme acetylcholinesterase (AChE) level diminished. These results reflect that accumulation of polypropylene microplastic should exacerbate harmful pollutants on filter-feeding organisms.
Assessing Enzyme Immobilization on Reverse Asymmetric Membranes and Biocatalytic Reactor Performance
Authors: Zahirulain Amirah Syakirah , Marpani Fauziah , Pauzi Syazana Mohamad , Rahim 'Azzah Nazihah Che Abd , Cao Hang Thi Thuy , Alias Nur Hashimah , Othman Nur Hidayati
Published: November 2021

Integration of membrane filtration and biocatalysis has appealing benefits in terms of simultaneous substrate conversion and product separation in one reactor. Nevertheless, the interaction between enzymes and membrane is complex and the mechanism of enzyme docking on membrane is similar to membrane fouling. In this study, focus is given on the assessment of enzyme immobilization mechanism on reverse asymmetric polymer membrane based on the permeate flux data during the procedure. Evaluation of membrane performance in terms of its permeability, fouling mechanisms, enzyme loading, enzyme reusability and biocatalytic productivity were also conducted. Alcohol Dehydrogenase (EC 1.1.1.1), able to catalyze formaldehyde to methanol with subsequent oxidation of NADH to NAD was selected as the model enzyme. Two commercial, asymmetric, flat sheet polymer membranes (PES and PVDF) were immobilized with the enzyme in the reverse mode. Combination of concentration polarization phenomenon and pressure driven filtration successfully immobilized almost 100% of the enzymes in the feed solutions. The biocatalytic membrane reactor recorded more than 90% conversion, stable permeate flux with no enzyme leaching even after 5 cycles. The technique showing promising results to be expanded to continuous membrane separation setup for repeated use of enzymes.
Parametric Investigation of EP To Enhance Surface Characteristics of Maraging Steel With Organic Electrolyte
Authors: Kumar Abhinav , Kumar Suraj , Das Manas
Published: November 2021

Maraging steel 300 is widely used in aircraft, tools, and automotive industries, which requires a polished surface for better performance. In conventional methods of polishing, the abrasives directly contact the workpiece surface and deteriorate its property. Thus, a non-conventional method like Electropolishing (EP), is utilized to finish maraging steel with acetic acid (99.7 wt.%) and perchloric acid (70 wt.%) mixed in the volume of 3:1. Linear sweep voltammetry (LSV) is performed to determine the passive region that gives the best electropolishing performance. Different parameters, namely temperature, agitation, and polishing time and their effect on surface roughness and surface reflectance, are observed during EP. The optimized process parameters which give the best EP performance are the temperature at 60ºC, rotation of magnetic stirrer at 400 rpm, and polishing time of 6 minutes. An improvement of 56% in surface roughness and 60% in surface reflectance from its initial value of 21% is observed. EP makes the surface hydrophilic as the contact angle changes from 111.2º to 68.6º. Energy-Dispersive X-Ray Spectroscopy analysis suggests that after EP, a metal oxide layer forms on the surface which helps in increasing corrosion resistance.
Effect of Mirogabalin on Chemotherapy-induced Peripheral Neuropathy Caused by Gemcitabine Plus Nab-paclitaxel Therapy in Pancreatic Cancer Patients: A Pilot Study
Authors: Takasaki Yusuke , Fujisawa Toshio , Ushio Mako , Takahashi Sho , Yamagata Wataru , Suzuki Akinori , Ito Koichi , Ochiai Kazushige , Tomishima Ko , Ishi Shigeto , Isayama Hiroyuki
Published: November 2021

PurposeGemcitabine/nab-paclitaxel therapy (GnP) is widely used to treat pancreatic cancer (PC), but chemotherapy-induced peripheral neuropathy (CIPN) is common. Mirogabalin is a novel drug for treating peripheral neuropathy. We investigated the effects of mirogabalin on CIPN due to GnP.MethodsPatients who had received GnP for PC and had taken mirogabalin for CIPN, were included. Patients completed a questionnaire about their symptoms before and after taking mirogabalin. The outcome was the change in numbness and tingling scores on the patient-reported outcomes version of the Common Terminology Criteria for Adverse Events, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire–Chemotherapy-Induced Peripheral Neuropathy (EORTC-QLQ-CIPN20), numerical rating scale, and adverse events (AEs).ResultsIncreased numbness and tingling severity (1.84 vs. 1.76; P=0.63) and interference (1.42 vs. 1.44; P=0.80) were not seen in any of the 25 enrolled patients. The scores on the sensory subscale of the EORTC-QLQ-CIPN improved significantly after treatment (17.5 vs. 15.7; P=0.02). AEs occurred in 22 patients (88%), but there were no serious AEs (≥ grade 3).ConclusionsMirogabalin may control the progression of CIPN caused by GnP and significantly improved sensory neuropathy. However, since the incidence of AEs is high, mirogabalin should be used with caution.
Body Mass Index and Serum Markers Associated with Progression Free Survival in Lung Cancer Patients Treated with Immune Checkpoint Inhibitors
Authors: Liu Zhenzhen , Diao Yuzhu , Li Xiaoling
Published: November 2021

Background: ICIs have remarkably affected the treatment strategies for numerous malignancies, including lung cancer. However, only a fraction of patients experiences durable responses to ICIs, thus there is an urgent need to identify the parameters related to ICIs therapeutic effect. In this study, we investigated nutritional status surrogates and several serum markers to estimate the efficacy of ICIs.Materials and methods: The records of 66 patients with stage Ⅲ/Ⅳ lung cancer who received ICIs were retrospectively analyzed. Features of patients’ clinical pathology, including age, sex, histology, line of treatment, BMI, serum albumin, serum creatinine, and serum inflammatory markers such as LMR and PLR, were examined. Progression-free survival was primary endpoints. Relationships among categorical variables were assessed by the chi-squared test. Survival analysis was performed using Kaplan–Meier method followed by log-rank test. Cox multivariate analysis was performed to analyze the association between each variable and the survival time of patients. Results: The patients with BMI≥25(kg/m2)，serum ALB≥37(g/dL)，serum creatinine≥61.8(μmol/L), LMR≥2.12 had a significantly prolonged PFS in comparison with BMI＜25(kg/m2)，ALB＜37(g/dL)，creatinine＜61.8(μmol/L)，LMR＜2.12 (p < 0.05). No statistically significant difference was detected between patients with PLR＜135 and PLR≥135 (p=0.612).The multivariate analysis revealed that ALB≥37(g/dL) and creatinine≥61.8(μmol/L) were associated with prolonged PFS, while statistical significance was not achieved in BMI groups. Conclusions: The current results indicated that high BMI is related to longer PFS in lung cancer patients treated with ICIs, which may be correlated with high levels of serum albumin and creatinine.
m 6 A-Related lncRNAs are Potential Biomarkers for Predicting Prognoses in Patients With Breast Cancer
Authors: Liao Yuwei , Liang Simon X , He Dong , Chen Zhikai , Yao Jinxiu , Liang Hongfeng , Yang Liye
Published: November 2021

Background: Breast cancer (BRCA) is a common cancer and major cause of cancer mortality in females around the world. N6-methyladenosine (m6A) and m6A-associated long non-coding RNAs (lncRNAs) play vital roles in the prognostic value of BRCA. However, how m6A-related lncRNAs affect the survival of BRCA patients remains unclear. Methods: In this study, we obtained m6A-related lncRNAs by gene co-expression and used univariate least absolute shrinkage and selection operator (LASSO), and multivariate Cox regression analyses to construct a comprehensive m6A-related lncRNA model. Based on this model, a risk score was calculated for each patient. Next, Kaplan-Meier analyses, cell type enrichment analysis, and gene ontology (GO) enrichment were used to analyze the risk model. Finally, performance comparison was made between risk model and other common prognostic biomarkers in BRCA using ROC curve and nomogram. Results: The comprehensive risk model of 39 genes (10 m6A-related lncRNAs and 29 other genes) and basic clinical factors showed better performance in BRCA prognosis compared to other common prognostic biomarkers. By regrouping the patients with this model, we found that patients in the high-risk group had higher tumor mutation burden (TMB) and differentially expressed genes between high- and low risk patients were enriched in tumor-related inflammation response pathway and lipid droplet pathway. Conclusions: These results demonstrate that our comprehensive 39-genes risk model based on the m6A-related lncRNAs is promising for clinical prediction and provides a treatment guide for BRCA patients.
Volatile dripping onto substrate (vDoS) extensional rheology of viscoelastic polymer solutions
Authors: Robertson Benjamin P. , Calabrese Michelle A.
Published: November 2021

Extensional flow properties of volatile polymer solutions govern many industrially-relevant coating processes, but existing instrumentation lacks the environmental control necessary to control evaporation. To mitigate evaporation during volatile dripping-onto-substrate (vDoS) extensional rheology measurements, we developed a chamber to enclose the sample in an environment saturated with solvent vapor. We validated the vDoS device by measuring a model high molecular weight polyethy-lene oxide (PEO) in various organic solvents both inside and outside of the chamber. Evaporation substantially increased the extensional relaxation time λ E for PEO in volatile solvents like dichloromethane (DCM) and chloroform. PEO/chloroform solutions displayed an over 20-fold increase in λ E due to the formation of an evaporation-induced surface film; evaporation studies confirmed surface features and skin formation reminiscent of buckling instabilities commonly observed during drying in polymer solutions. Finally, the relaxation times of semi-dilute PEO/chloroform solutions were measured with environmental control, where λ E scaled with concentration by the exponent m=0.62. These measurements validate the vDoS device by confirming that chloroform is a good solvent for PEO, with a Flory exponent of ν=0.54. Our results demonstrate the first environmental control of evaporation during DoS extensional rheology, and provide guidelines establishing when environmental control is necessary to obtain accurate rheological parameters.
Sodium Arsenite Induces Bronchial Epithelial Cell Cancer With Mitochondrial Dysfunction by Affecting Cell Cycle
Authors: Liu Rong , Deng Zifeng , Lin Mo , Ruan Fengkai , Luo Guangping , Luo Zhen , Dou Liangding , Wang Lei , Qiu Guihua , Huang Zhi , Hou Xin , Yao Youliang , Zhang Yongxing
Published: November 2021

Background: Arsenide, a kind of pollution widely existing in the environment, and the mechanism of occurrence and development of lung cancer leading by long-term arsenic exposure still needs further research up to present. We investigated how high and low doses of arsenic induce human bronchial epithelial cell transformation and the molecular mechanisms involvedMethods: After exposing human bronchial epithelial cells(Beas-2B) to different doses of sodium arsenite for 24 h, RNA-seq analysis was performed to detect arsenic-regulated genes; for cell viability and status and for cell cycle changes and mitochondrial function; long-term exposure to 1μM sodium arsenite after 20 consecutive passages for cell cycle changes and mitochondrial function.Results: In the study, human bronchial epithelial cells were exposed to varying high-dose sodium arsenite in short term or treated with low dose in a long term, and the data showed that both short and long terms treatment promoted G1/S transition of Beas-2B cells, inducing significant increases of expression of AKAP95, cyclin D1, cyclin D2 and cyclin E1. However, silencing AKAP95 by treating cells with siAKAP95 showed a protective function that inhibited G1/S transition, suggesting that regulatory mechanism of AKAP95 on cell cycle during cell malignant transformation induced by sodium arsenite. In addition, we also noticed some mitochondrial dysfunctions occurred during sodium arsenite exposure, including the disappearance of mitochondrial double membrane structure, the formation of vacuole structure, the decrease of mitochondrial membrane potential, the change of expression levels of mitochondrial related proteins Tim22, Tim23, Tom40 and OPA1, the release of lactate dehydrogenase (LDH) and the decrease of reduced glutathione.Beas-2B cells, which exposed to low-dose sodium arsenite for a long term, were subcultured for 20 generations, and it was found that the exposure time was positively proportional to the growth and migration rate of cells. The exposed cells were used in tumor bearing transplantation experiment (mice), and results showed that the longer the exposure time, the faster the tumor volume growth rate of As-Beas-2B cells. Tumor tissues were taken out for HE staining, and it was found that the cell morphology changed and the volume increasedConclusion: high and low doses of sodium arsenite induced malignant transformation of human bronchial epithelial cells by promoting G1/S turnover through AKAP95 with associated cyclins, accompanied by the development of mitochondrial dysfunction.
Efficacy and Safety of Bivalirudin Versus Heparin Anticoagulation Therapy for Extracorporeal Membrane Oxygenation: Meta-Analysis
Authors: Gu Jie , Yu Hongjie , Lin Dang
Published: November 2021

Background

We aimed to compare the efficacy and safety of bivalirudin versus heparin as the anticoagulant in patients undergoing Extracorporeal Membrane Oxygenation (ECMO).
Methods

We conducted a search in PubMed, Embase and the Cochrane Library for all the studies in which bivalirudin was compared to heparin as the anticoagulant for ECMO. Efficacy outcomes were defined as the time to reach therapeutic levels, time within therapeutic range (TTR), thrombotic events, circuit thrombosis, circuit exchanges. Safety outcomes were reported as Heparin-Induced Thrombocytopenia (HIT), major bleeding events, minor bleeding events. Other outcomes included hospital length of stay (LOS), ICU LOS, mortality, 30-day mortality and in-hospital mortality.
Results

Ten studies were included, involving 1091 patients (Bivalirudin was administered in 405 patients while 686 patients were treated with heparin). A significant reduction in thrombotic events [OR 0.51, 95%CI 0.36,0.73, p=0.0002, I2=0%], major bleeding events [OR 0.31, 95%CI 0.10,0.92, p=0.04, I2=75%] and in-hospital mortality [OR 0.63, 95%CI 0.44,0.89, p=0.009, I2=0%] treated with bivalirudin were found compared with heparin. There were no significant differences between groups regarding the time to reach therapeutic levels[MD 3.53, 95%CI -4.02,11.09, p=0.36, I2=49%], TTR[MD 8.64, 95%CI -1.72,18.65, p=0.10, I2=77%], circuit exchanges[OR 0.92, 95%CI 0.27,3.12, p=0.90, I2=38%], Heparin-Induced Thrombocytopenia (HIT)[OR 0.25, 95%CI 0.02,2.52, p=0.24, I2=0%], minor bleeding events[OR 0.93, 95%CI 0.38,2.29, p=0.87, I2=0%], hospital LOS[MD -2.93, 95%CI -9.01,3.15, p=0.34, I2=45%], ICU LOS[MD -4.22, 95%CI -10.07,1.62, p=0.16, I2=0%], mortality[OR 1.84, 95%CI 0.58,5.85, p=0.30, I2=60%] and 30-day mortality[OR 0.75, 95%CI 0.38,1.48, p=0.41, I2=0%]. The benefit of bivalirudin over heparin was not significant for patients undergoing ECMO for major bleeding events while ruling out the Rivosecchi’s study (OR 0.44, 95%CI 0.71-1.14). Subgroup analysis by patient’s type revealed that studies in children generated lower rate of thrombotic events and major bleeding events compared with adults.
Conclusion

Our meta-analysis suggests that bivalirudin use as the anticoagulant for ECMO are associated with lower thrombotic events, major bleeding events and in-hospital mortality. Meanwhile, the differences are more pronounced in children than adults. However, the results should be interpreted with caution and further larger, randomized trials are needed to confirm the results.
Midgut-Specific Expression of P450 Gene Increases Deltamethrin Tolerance in The Fall Armyworm, Spodoptera Frugiperda
Authors: Palli Subba Reddy , Chen Xien
Published: November 2021

The piggyBac-based germline transformation system was recently established in a global agricultural pest, the fall armyworm (FAW), Spodoptera frugiperda. Tissue-specific promoters are needed to apply this transformation system to express transgenes in a tissue-specific manner. Highly expressed genes in the midgut were identified by RNA sequencing and RT-qPCR. Promoter regions of 11 genes highly expressed in the midgut were identified and cloned. Baculoviruses expressing the luciferase under the control of these promoters were produced and tested in the FAW. These baculoviruses did not show significant luciferase activity in the FAW midgut. Four transgenic FAW lines, expressing the luciferase under the control of SfSP38/P2000, SfCalphotin/P2000, SfMG17/P2000, and SfCPH38/P2000 promoters were generated using piggyBac-based germline transformation methods. Significantly higher luciferase activity was detected in the midgut than in other tissues of transgenic FAW. SfCPH38/P2000 promoter with the highest activity and midgut-specificity was used to drive the expression of a P450, SfCYP321A8 known to be involved in deltamethrin resistance. Higher mRNA levels of SfCYP321A8 and P450 activity were detected in the midgut of transgenic larvae than in wild-type larvae. Bioassays showed that the transgenic larvae expressing SfCYP321A8 in the midgut are tolerant to deltamethrin. Here, we presented methods for the identification of midgut-specific promoters in the FAW and used them to study the role of P450 overexpression in the midgut on insecticide resistance. These methods could also be used to identify other tissue-specific promoters for applications of piggyBac-based germline transformation in functional genomics in FAW and other non-model insects.
Current priorities of the program content ‘Around the world’, for first and second grade in primary school, with an accent inclusive education
Authors: Ekaterina Ivanova
Published: November 2021

Positive changes in the educational system of Bulgaria towards the process of inclusion, namely to ensure equal access to quality education for each child, regardless of his health or social status, ethnic or religious affiliation, also reflect on the program content of “Around the world” for first and second grade in primary school. The subject is aimed at enriching the sensory cognitive experience of children, as well as mastering related to their close public and social environment, knowledge and skills. By accepting a social role student, the child learns another type of interaction with others, acquires the skills to listen and talk with his interlocutors, focus on tasks. The current program content of the learning themes focuses on priorities such as: skills of deal with problems, communication with other students and manifestation of tolerant relationships, and acceptance of differences. The artistic-illustrative material depicting events, situations, circumstances of everyday life of students, bringing them closer to reality. Tasks require students to work independently: monitoring, research, data collection, sharing personal experiences, group work, and this promotes the development of their intellectual potential, as well as successful adaptation, socialization and inclusion in society.
Strategies to control and address aggression in school
Authors: Deyan Staykov
Published: November 2021

Violence has become part of our daily lives. We meet it in real life, on the TV in the computer room. Each of you probably know about the case of child victims of violence – in school, on the street or home. More serious problem is the aggressiveness of students to one another. Many of them feel seriously threatened and forced to resort to self-defense, but some – even refuse to go to school. The problems of adolescents are always up to date, but in times of social instability and moral values, devalue sharpen. Bad micro social conditions are a source of psychological traumas. Adolescents appear to be more susceptible to stressful situations in the family and in society in general. We all experience personal and public dramas but youth is prone to radical reactions due to mental and physical characteristics of the age.
Developing children emotional intelligence through game and movement situational trening
Authors: Sanda Toma-Urichianu
Published: November 2021

This study refers to the socio-emotional, psychological and motor skills development in children. School must give more attention to the harmonious physical and mental development of children, especially at elementary school age when study and movement represent their main activities. Hypothesis: In this study we aim at demonstrating that increasing the dynamic games instructive-educational potential we can achieve children emotional intelligence development and better adjusting to the demands of the school and social environment. Results: Some educated, proficient and highly scoring children can’t manage to have friends, are not happy with their careers, and lives. What makes the difference is a certain development level of social, emotional psychological and movement skills. Conclusions: Social, emotional and motor development contribute heavily to future personal and professional achievements of children. Keywords: competence, emotional intelligence, development, education, school age.
Level of the specific motricity of the begginers women soccer players (10-12 years old)
Authors: D V Gidu
Published: November 2021

Aim. The aim of this study is to assess the level of the specific motricity of the beginer women soccer players. Method. In this study were participated 20 women soccer players from Selena SN Constanta junior team. To investigate the specific abilities of girls there were used tests mentioned by the literature: juggling, the precision of the shot, controlled speed dribling, kicking ball, dribbling through cones. Results. At all tests our girls obtaining significant smaller values than those proposed by our Federation for boys same age (10-12 years old).Conclusions. The level of specific motricity in beginer women soccer players from our junior team is one unsatisfactory.
A war scenario in the Black Sea area. Secondary operation Dobrogea
Authors: Marian ZIDARU
Published: November 2021

In the course of 2018, on the background of increasing tensions with USA on Ukraine and Siria, Russian President Vladimir Putin decide to liquidate the conflict in Ukraine by destroying Ukrainian army and invading southern part of this country. The aims of the operation, are: -Denial of Ukraine access to the Black Sea; -Getting Russia's access to Danube. -Providing Russia's access from the mainland to the Crimea; -Preventing the creation of NATO's bases in southern Ukraine. As a Secondary Direction: An attack against Dobrogea in order to distract NATO's main operation and prevent the alliance to intervene before reaching primary objective in Ukraine by Russian troops: conquering the south of Ukraine. We develop this scenario in order to show our defense weaknesses at the Black Sea area.
Black Sea littoral military operations - environment impact
Authors: V Novac
Published: November 2021

The firstobjective of this article is to highlight the main features of the Black Sea environmentfrom the perspective of the military littoral operations.Variousoceanographic data, especially wind and wave data coming from observations or numericalmodelswere analyzed in order to find out the aspects which impact on the military littoral operations as a whole, as also the equipment, sensors, personnel or tactics. The present paper also gives some tactical guidance regarding planning and executing such operations and draw a comparison between the littoral battle space and open-sea warfare.
Some features of intraoperative infusion-transfusion therapy when performing cytoreductive operations with the use of hyperthermic intraperitoneal chemotherapy in patients with ovarian cancer: retrospective cohort study
Authors: Morikov D. D. , Shelekhov A. V. , Gorbachev Vladimir I. , Dvornichenko V. V. , Pavlov A. G. , Radostev S. I.
Published: November 2021

Introduction. Сytoreductive operations with using hyperthermic intraoperative intraperitoneal chemotherapy(CR + HIPEC) is an effective technology in the treatment of locally advanced and metastatic ovarian cancer, the relevance of the treatment of this one’s is beyond doubt. The neсessity of protection organs and systems of the body from a stress response, correction of water and electrolyte balance, blood loss, volemia, and prevention of the toxic effects of chemotherapy make infusion-transfusion therapy (ITT) one of the main components of anesthesia during such operations. Objectives. An analyze the qualitative and quantitative composition of perioperative infusion-transfusion therapy in patients with advanced stages of ovarian cancer during cytoreductive operation with the addition of HIPEC of the abdominal cavity. Materials and methods. In retrospective study 84 patients, 2 types of surgical interventions and anesthetic accompaniment were analyzed, depending on the availability of HIPEC. The duration of the anesthetic treatment, the doses of the anesthetics, the volume of blood loss, the volume and quality of intraoperative infusion therapy were assessed. Results. With ITT carried out with cytoreduction using GIIH, the volume of administration of crystalloid solutions increases by 2.3 times; the average value of the infusion volume increases by 16 (10,5–20) ml/kg/hour. When analyzing the proportional ratio of crystalloid and colloidal solutions, their qualitative composition with CR + GIIH consists of: erythrocyte suspension 3.1 %, FFP 13.6 %, colloidal solutions 8.52 %, crystalloid solutions 74.6 % of total infusion’s volume. Conclusions. Perioperative ITT performed with cytoreduction using GIIH differs significantly from ITT without that. The necessity for high-volume infusion-transfusion therapy by increasing the introduction of crystalloids during cytoreductive operations with hyperthermic intraoperative intraperitoneal chemotherapy was revealed. This technique had no complications and allowed maintaining the stability of hemodynamics, volumetric volume and the required volume of diuresis. The use of a “balanced electrolyte solution” is preferable for intraoperative high-volume ITT.
The Holistic Approach in Education Development Programs: Case of Indonesia Mengajar
Authors: Fibra Adsina , Berewot Juliana
Published: November 2021

This paper aims to describe one of sustainable projects of improving education quality in archipelagic nations. Indonesia Mengajar is an Indonesian NGO based in Jakarta which promotes volunteerism by being young educators. Their projects aim to fill the shortage of primary school teachers, especially in remote areas. By sending the best Indonesian university graduates which have been intensively trained to work as teachers for one consecutive year, it was expected they will be able to inspire young people to choose careers as educators. It is a qualitative study on how the organization plans and executes their projects. The findings stimulate further questions on how to solve the issue of quality education in Indonesia.
Vocational English Training for “Go Clean” Partners
Authors: Herlina Clara
Published: November 2021

Nowadays, almost all people living in Jakarta use application for everyday needs, from transportation, buy food until cleaning houses. One of the companies that provide those services through online application is GOJEK.  GOJEK offered a lot of services, such as GO Ride, GO Food, GO Massage and Go Clean.  Go Clean is particularly giving service for cleaning houses or apartments and it has a lot of customers.  Unfortunately, Go Clean partners often have to decline customers, particularly foreigners, because they are not able to converse in English. Thus, this community program is created to give training to Go Clean partners so that they will be able to conduct a simple conversation in English with foreign customers. The materials include introduction, parts of the house and price negotiation. After the training, it is expected that the workers will gain more customers and eventually it will increase their income.
TOEFL Preparation for University Students’ Candidates from Asak Paroki MKK
Authors: Herlina Clara
Published: November 2021

Some private universities in Jakarta use TOEFL or TOEFL-like test as the admission requirement for new students.  Therefore, students’ candidates should prepare well to achieve the minimum score for being admitted. Unfortunately, their high school did not give enough training in doing the TOEFL test. The purpose of this community development program is to train high school students to do TOEFL test, especially the Reading section.  The participants of the program were seven 12th grade high school students who were included in ASAK Paroki MKK community.  They were trying to qualify for admission in Binus University.  The program was created in the form of classroom teaching and individual assignment.  In this program, we taught them about the TOEFL Reading test types, strategies and tips for doing the test.  After the training, the students reported their understanding of TOEFL and confidence in preparing the university admission test.
Exuberant as Trend Forecast Method for Kertabumi Klinik Sampah Community Plastic Recycling
Authors: Chadijah Siti , Latif Fauziah , Fanthi Reno
Published: November 2021

Recycling movement is such a never- ending campaign. This movement are grown larger in the society whether in individual or group activities. Any of the groups with the same spirit and vision are blurred in the community to achieve wider impact of recycling plastic. One of the active campaigner is Kertabumi Klinik  Sampah which  well-known  in  tinkering any  of  the  recycling technique within the communities around Jakarta. Communities under Kertabumi facilitation are encouraged to turned plastic waste into unique and valuable products. Fostering creativity is the idea of this research aiming to observe the possibility of trend design implementation on the plastic recycle product. Exuberant trend forecasting is used as an approach to designing functional and aesthetical aspect on the product. Moreover, the styling result is offered as a design recommendation for the community to develop their product in the future.
Empowering Teacher Engagement in Primary Schools Through Video Intervention Program
Authors: Rabiha Sucianna Ghadati , Sasmoko Sasmoko , Indrianti Yasinta
Published: November 2021

Teacher engagement basically shows that the personal and existence of a qualified teacher is positioned not only as a teacher but as an integrated whole of an educator who is professional and has an Indonesian character. This concept is in line with the mandate of the 2015-2019 RPJMN as stipulated in the Ministry of Research and Technology Strategic Plan where the government seeks to strengthen overall development by emphasizing the development of economic competitive advantages, one of which is based on quality institutions and resources. Based on the results of the trials conducted, it can be concluded that the engagement of elementary school teachers in Jakarta, Bekasi and South Tangerang can be increased through the Video Intervention Program. After empowering teachers through the Video Intervention Program, elementary school teachers in Jakarta, Bekasi and South Tangerang experienced significant engagement at α<0.05. Furthermore, through the results of the self-assessment, it was found that teacher empowerment through the Video Intervention Program will further increase teacher engagement in Jakarta, Bekasi and South Tangerang, if these teachers improve themselves in carrying out religious orders.