bluuebunny/crossref_metadata_2025 huggingface dataset:
NOVEL SCHEME FOR THE FRACTAL–FRACTIONAL SHORT WATER WAVE MODEL WITH UNSMOOTH BOUNDARIES
Authors: WANG KANGLE
Published: November 2022

In this paper, for the first time, the fractal–fractional short water wave model (FFSWWM) is used to simulate the propagation of seawater waves with unsmooth boundaries or in microgravity, where the conformable fractional derivative sense is adopted. A new and simple approach is presented to derive a variety of fractal solitary wave solutions of FFSWWM, which is called the sech function wave method. These obtained fractal solitary wave solutions are completely new and different from the existing literature. The fractal dynamical behavior of the gained fractal solitary wave solutions is presented by sketching some 2D and 3D graphics with different fractal dimensions and fractal parameters, which are very helpful for further study of the propagation of complex ocean waves.
Comparing Norm-Based and Role-Based Strategies for Robot Communication of Role-Grounded Moral Norms
Authors: Wen Ruchen , Kim Boyoung , Phillips Elizabeth , Zhu Qin , Williams Tom
Published: November 2022

Because robots are perceived as moral agents, they must behave in accordance with human systems of morality. This responsibility is especially acute for language-capable robots because moral communication is a method for building moral ecosystems. Language capable robots must not only make sure that what they say adheres to moral norms; they must also actively engage in moral communication to regulate and encourage human compliance with those norms. In this work, we describe four experiments (total
N
=316) across which we systematically evaluate two different moral communication strategies that robots could use to influence human behavior: a norm-based strategy grounded in deontological ethics, and a role-based strategy grounded in role ethics. Specifically, we assess the effectiveness of robots that use these two strategies to encourage human compliance with norms grounded in expectations of behavior associated with certain social roles. Our results suggest two major findings, demonstrating the importance of moral reflection and moral practice for effective moral communication: First, opportunities for reflection on ethical principles may increase the efficacy of robots’ role-based moral language; and second, following robots’ moral language with opportunities for moral practice may facilitate role-based moral cultivation.
Effect of Recombination Catalyst Loading in PEMWE Membranes on Anodic Hydrogen Content Reduction
Authors: Abbas Dunia , Martin Agate , Trinke Patrick , Bierling Markus , Bensmann Boris , Thiele Simon , Hanke-Rauschenbach Richard , Böhm Thomas
Published: November 2022

Integrating platinum-based recombination catalysts into proton exchange membrane water electrolysis systems effectively reduces the anodic hydrogen content. We studied the effect of the platinum loading of an interlayer close to the anode within the membrane on the anodic hydrogen in oxygen content. For the investigated Pt-loadings between 1 μgPt cm−2 and 140 μgPt cm−2, the results revealed that for a 110 μm membrane, 7 μgPt cm−2 were sufficient to allow a safe operation at cathode pressures up to 10 bar. A further increase of the Pt-loading did not significantly improve the reduction of the anodic hydrogen in oxygen content.
Effect of Flow Conditions of Anode Hydrogen on Net Water Drag Coefficient of Polymer Electrolyte Fuel Cells
Authors: Ito Hiroshi , Wang Renjie , Ishida Masayoshi , Someya Satoshi , Munakata Tetsuo
Published: November 2022

The net water drag coefficient (

α

NWD

) is supposedly an essential index in water management, and must be negative for system operation for polymer electrolyte fuel cell (PEFC) systems. In this study,

α

NWD

is carefully examined by measurement of the water content in the gases supplied to and those discharged from the cell/stack under gas supply conditions similar to those in a real PEFC system. We focus on the effect of anode hydrogen (H2) flow conditions (i.e., flow rate and relative humidity) on

α

NWD

under a constant flow condition of cathode air. Measured characteristics of current density (

i

)-

α

NWD

in which the relative humidity of discharged H2 from the anode is constant at around 100%, show that

α

NWD

is stable when

i

exceeds a certain threshold. The value of

α

NWD

in this stable region is particularly sensitive to changes in the stoichiometric ratio of H2. These measurements also suggest that in the

α

NWD

stable region, almost the entire area of the membrane is fully hydrated, and the effect of back diffusion on

α

NWD

becomes negligible. Analysis of the observed relationships between

α

NWD

and several variables indicate that increasing the H2 circulation flow rate effectively prevents anode dry-out.
Prevalence of Campylobacter Species on Cattle Breeding Farms in Zimbabwe
Authors: Mahlangu Precious , Marambe Stephen T. , Mutengwa Iredale K. , Saidi Bamusi , Makaya Pious V. , Kagira John
Published: November 2022

Infertility remains a challenge in breeding herds in most developing countries. In the current study, 104 penile sheath washes were collected from bulls of different breeds and ages from different cattle breeding farms in Zimbabwe. The samples were submitted to the Central Veterinary Laboratory, Zimbabwe, for screening of Campylobacter species using the polymerase chain reaction (PCR). Based on the PCR results, the animal-level prevalence was 25.96% (range 0–73.98%) and all the positive samples came from four (57.14%) of the 7 herds tested. The current study shows that Campylobacter spp. could be a causative agent in infertility observed in a number of herds in Zimbabwe. Strategies for treatment and control of campylobacteriosis should be enhanced in the country. More research and surveillance are needed to determine the epidemiology of Campylobacter species in Zimbabwean cattle herds.
Hydrological and Meteorological Drought Monitoring and Trend Analysis in Abbay River Basin, Ethiopia
Authors: Abera Tareke Kassa , Gebeyehu Awoke Admasu
Published: November 2022

The definition of drought is very controversial due to its multi-dimensional impact and slow propagation in onset and end. Predicting the accurate occurrence of drought remains a challenging task for researchers. The study focused on hydrological and meteorological drought monitoring and trend analysis in the Abbay river basin, using the streamflow drought index (SDI), standardized precipitation index (SPI), and reconnaissance drought index (RDI), respectively, to fill this research gap. The study also looked into the interrelationships between the two drought indicators. The SDI, SPI, and RDI were calculated using long-term streamflow, precipitation, and temperature data collected from 1973 to 2014. The data were collected from eight streamflow stations and fifteen meteorological gauge stations. DrinC software (Drought Indices Calculator) was used to calculate the SDI, SPI, and RDI values. The result from meteorological drought using SPI12 and RDI12 shows that 1975, 1981, 1984, 1986, 1991, 1994, and 2010 were extreme drought years, whereas 1983, 1984, 2001, and 2010 were the most extreme hydrological drought years based on the SDI12 result. Except for Bahir Dar and Gondar, a severe drought occurs at least once a decade in all stations considered in this study. In general, the SPI, RDI, and SDI results indicated that the study area was exposed to the most prolonged severe and extreme drought from 1981 to 1991. The findings of this study also demonstrated that the occurrence of hydrometeorological droughts in the Abbay river basin has a positive correlation at long time scales of 6 and 12 months. The trend analysis using the Mann–Kendall test implied that there was a significant meteorological drought trend in two stations (Debre Berhan and Fiche) at SPI12 and RDI12 time scale, but for the remaining thirteen stations, there is no trend in all time scales. The hydrological drought trend analysis in the basin on a seasonal (SDI3) and yearly (SDI12) time scale also revealed that three streamflow stations have a positive trend (Kessie, Gummera, and Border). This implies that water resource management is still a vital tool for the sustainable development of the Abbay river basin in the future.
A Rapid and Satisfactory Outcome with Combined Immunosuppressive Therapy in Acquired Haemophilia A with Underlying Tuberculosis
Authors: Gamakaranage G. A. C. , Kulathilake C. , Nadeeshani P. G. N. , Fernandopulle K. H. B. P. , Moonesinghe C. S. , Gunawardena D. , Gamage R. S. , Perera N. , Indrakumar J.
Published: November 2022

Acquired haemophilia A (AHA) is a rare disorder with an incidence of 1.5 cases per million per year in the United Kingdom. The incidence could be underestimated due to difficulty in diagnosis and also due to the fact that people with low titre inhibitor levels are asymptomatic. It is usually a disease affecting elderly but a disease peak in the younger population is known. The common underlying diseases are autoimmune disorders, malignancies, infections, and drugs. However, approximately 50% of the cases do not have a specific aetiology and about 10% will not have bleeding manifestations. Therefore, an isolated prolongation of APTT should be evaluated, especially prior to any haemostatic challenges. We report a case of a middle-aged man who presented with bleeding due to AHA associated with high inhibitory titres and active pulmonary tuberculosis. He was treated with both antituberculous and combined-aggressive immunosuppressive therapy which resulted in satisfactory disease remission.
ATAD2 Upregulation Promotes Tumor Growth and Angiogenesis in Endometrial Cancer and Is Associated with Its Immune Infiltration
Authors: Wang Can , Yin Yue , Sun Zhenxing , Wang Yiru , Li Fei , Wang Yan , Zhang Zexue , Chen Xiuwei
Published: November 2022

Background. Endometrial cancer is one of the three major gynecologic malignancies, and its incidence continues to rise. ATPase family AAA structural domain-containing protein 2 (ATAD2) is an ATPase protein, which is an independent factor for poor prognosis in endometrial cancer. However, its role in the disease is yet to be determined. Methods. The Tumor IMmune Estimation Resource (TIMER) database was used to assess ATAD2 expression in pan-cancer, and the relevance of ATAD2 expression in Uterine Corpus Endometrial Carcinoma (UCEC) in clinical settings was obtained using Gene Expression Profiling Interactive Analysis (GEPIA) and UALCAN analysis. In addition, the Human Protein Atlas database was used to assess ATAD2 protein expression in UCEC. Furthermore, in vitro molecular biology and in vivo functional experiments were employed to ascertain the effect of ATAD2 expression on tumor angiogenesis and tumor growth. UALCAN was used to screen for ATAD2 coexpressed genes, and Sangerbox was utilized to perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of these coexpressed genes. Finally, the TIMER, Tumor Immune System Interaction and Drug Bank (TISIDB), and GEPIA databases were used to analyze the relationship between ATAD2 and immune infiltration. Results. ATAD2 is highly expressed in a variety of tumors, and in UCEC, it plays the role of a protooncogene. Basic experiments revealed that ATAD2 promotes vascular endothelial growth factor expression in endometrial cancer and affects tumor growth and angiogenesis. In addition, GO and KEGG enrichment analyses showed that ATAD2-associated genes were chiefly enriched in certain signaling pathways, such as herpes simplex virus 1 infection and that ATAD2 was associated with immune infiltration in UCEC. Conclusion. Our findings suggest that ATAD2 promotes tumor growth and angiogenesis in endometrial cancer. Furthermore, ATAD2 is associated with immune infiltration and is a potential diagnostic and therapeutic target.
EphA2 Promotes the Development of Cervical Cancer through the CXCL11/PD-L1 Pathway
Authors: Zhao Xinyue , Liu Jiaxi , Jin Dongdong , Ren Chenchen , Yang Li , Zhu Yuanhang , Huang Changhao , Ding Leilei , Wu Zimeng , Shen Ke , Zhang Zhen’an , Chen Huanhuan , Wang Nannan
Published: November 2022

Erythropoietin-producing hepatoma receptor A2 (EphA2), receptor tyrosine kinase, the most widespread member of the largest receptor tyrosine kinase family, plays a critical role in physiological and pathological conditions. In recent years, the role of EphA2 in the occurrence and development of cancer has become a research hotspot and is considered a promising potential target. Our previous studies have shown that EphA2 has an indisputable cancer-promoting role in cervical cancer, but its related mechanism requires further research. In this study, high-throughput sequencing was performed on EphA2 knockdown cervical cancer cells and the control group. An analysis of differentially expressed genes revealed that EphA2 may exert its cancer-promoting effect through C-X-C motif chemokine ligand 11 (CXCL11). In addition, we found that EphA2 could further regulate programmed cell death ligand 1 (PD-L1) through CXCL11. This has also been further demonstrated in in vivo experiments. Our study demonstrated that EphA2 plays a tumor-promoting role in cervical carcinoma through the CXCL11/PD-L1 pathway, providing new guidance for the targeted therapy and combination therapy of cervical carcinoma.
Efficacy of Surgery in Patients with Stage I Primary Parotid Gland Lymphoma: A Population-Based Study
Authors: He Xiaoyu , Gang Dongxu , Zhang Xiaoyuan , Ding Hanyi , Jiang Songfu
Published: November 2022

Background. Limited and controversial evidence is available on the efficacy of surgery for patients with stage I primary parotid gland lymphoma. Thus, we aimed to investigate whether surgery can enhance the prognosis of patients with stage I primary parotid gland lymphoma using large sample data. Methods. From 1998 to 2015, we searched the Surveillance, Epidemiology, and End Results (SEER) program database and extracted information regarding patients with stage I primary parotid gland lymphoma; we classified these patients into surgery and nonsurgery groups. We calculated overall survival (OS) and cancer-specific survival (CSS) using Kaplan–Meier curves and log-rank testing. Propensity score matching (PSM) analysis was also used to further account for confounding variables before comparing the OS and CSS again. We used the COX proportional hazard regression model in both multivariate and univariate analyses. Results. We enrolled 918 patients with stage I primary parotid gland lymphoma, among which 656 (71.5%) patients underwent surgery. Before PSM, the surgery group had better OS (hazard ratio (HR) = 0.673, 95% confidence interval (CI): 0.519–0.873, andp=0.003) and CSS (HR = 0.595, 95% CI: 0.403–0.879, andp=0.008) than the nonsurgery group. After PSM, surgery was still a beneficial factor for OS (HR = 0.569, 95% CI: 0.399–0.810, andp=0.002) and CSS (HR = 0.384, 95% CI: 0.220–0.669, andp=0.001). Furthermore, in univariate and multivariate analyses, total parotidectomy significantly increased OS (p=0.001andp=0.021, respectively) and CSS (p=0.001andp=0.037, respectively). Conclusions. In summary, the prognosis of patients with stage I primary parotid gland lymphoma can be significantly improved by surgery. Moreover, total parotidectomy was a protective factor for OS and CSS before and after PSM analysis, suggesting that surgery acts as a significant component in multimodal therapy for early primary parotid gland lymphoma.
Fractional Conformable Stochastic Integrodifferential Equations: Existence, Uniqueness, and Numerical Simulations Utilizing the Shifted Legendre Spectral Collocation Algorithm
Authors: Badawi Haneen , Shawagfeh Nabil , Abu Arqub Omar
Published: November 2022

Theoretical and numerical studies of fractional conformable stochastic integrodifferential equations are introduced in this study. Herein, to emphasize the solution’s existence, we provide proof based on Picard iterations and Arzela−Ascoli’s theorem, whilst the proof of the uniqueness mainly depends on the famous Gronwall’s inequality. Also, we introduce the basic concepts related to shifted Legendre orthogonal polynomials which are utilized to be the basic functions of the spectral collocation algorithm to obtain approximate solutions for the mentioned equations that are not easy to be solved analytically. The substantial idea of the proposed algorithm is to transform such equations into a system containing a finite number of algebraic equations that can be treated using familiar numerical methods. For computational aims, we make a suitable discretization to evaluate the values of the Brownian motion, the noise term considered in our problem, at specific points. In addition, the feasibility and efficiency of the proposed algorithm are proved through convergence analysis and mathematical examples. To exhibit the mathematical simulation, graphs and tables are lucidly shown. Obviously, the physical interpretation of the displayed graphics accurately describes the behavior of the solutions. Despite the simplicity of the presented technique, it produces accurate and reasonable results as notarized in the conclusion section.
Enhancing Reproductive Performance of Freshwater Finfish Species through Dietary Lipids
Authors: Torsabo Donald , Ishak Sairatul Dahlianis , Noordin Noordiyana Mat , Koh Ivan Chong Chu , Abduh Muhammad Yazed , Iber Benedict Terkula , Kuah Meng-Kiat , Abol-Munafi Ambok Bolong
Published: November 2022

Dietary lipid manipulation in the feed of commercially cultured finfish is used not only to improve production and culture but also to enhance their reproductive performances. The inclusion of lipid in broodstock diet positively affects growth, immunological responses, gonadogenesis, and larval survival. In this review, existing literature on the importance of freshwater finfish species to aquaculture and the inclusion of dietary lipid compounds in freshwater fish feed to accelerate the reproduction rate is being summarized and discussed. Although lipid compounds have been confirmed to improve reproductive performance, only a few members of the most economically important species have reaped benefits from quantitative and qualitative lipid studies. There is a knowledge gap on the effective inclusion and utilization of dietary lipids on gonad maturation, fecundity, fertilization, egg morphology, hatching rate, and consequently, larval quality contributing to the survival and good performance of freshwater fish culture. This review provides a baseline for potential future research for optimizing dietary lipid inclusion in freshwater broodstock diets.
Screening of Hub Genes in Hepatocellular Carcinoma Based on Network Analysis and Machine Learning
Authors: Zhang Yu , Xie Yongfang , Huang Xiaorong , Zhang Langlang , Shu Kunxian
Published: November 2022

Hepatocellular carcinoma (LIHC) is the fifth common cancer worldwide, and it requires effective diagnosis and treatment to prevent aggressive metastasis. The purpose of this study was to construct a machine learning-based diagnostic model for the diagnosis of liver cancer. Using weighted correlation network analysis (WGCNA), univariate analysis, and Lasso-Cox regression analysis, protein-protein interactions network analysis is used to construct gene networks from transcriptome data of hepatocellular carcinoma patients and find hub genes for machine learning. The five models, including gradient boosting, random forest, support vector machine, logistic regression, and integrated learning, were to identify a multigene prediction model of patients. Immunological assessment, TP53 gene mutation and promoter methylation level analysis, and KEGG pathway analysis were performed on these groups. Potential drug molecular targets for the corresponding hepatocellular carcinomas were obtained by molecular docking for analysis, resulting in the screening of 2 modules that may be relevant to the survival of hepatocellular carcinoma patients, and the construction of 5 diagnostic models and multiple interaction networks. The modes of action of drug-molecule interactions that may be effective against hepatocellular carcinoma core genes CCNA2, CCNB1, and CDK1 were investigated. This study is expected to provide research ideas for early diagnosis of hepatocellular carcinoma.
Effect of Elevated Temperature on the Properties of Self‐Compacting Mortar Containing Nanomaterials and Zircon Sand
Authors: Ruben Sahaya , Sophia M. , Raja M. A. , Masi Chandran
Published: November 2022

The present research work tries to assess the performance of a self‐compacting mortar containing zircon sand as a substitute for river aggregate in combination with nanoalumina and nanosilica as cement replacements. The fresh state results, as observed through the mini slump cone and mini V funnel, showed positive effects of zircon sand on workability attainment. The EFNARC limits of workability were even satisfied at high substitution levels of the nanoparticle due to the contribution of zircon sand. The mechanical properties, durability, and microstructure of the mortar were evaluated by conducting experiments at room temperature and then at 200°C, 400°C, 600°C, and 800°C. Results show that there was a significant improvement in the thermal stability of the RPC mixes due to the synergistic effect of nanomaterials and zircon sand addition. The addition of nanomaterials and zircon sand accelerated the microstructural buildup and durability at elevated temperatures. The findings thus suggest a novel and effective approach to using zircon sand as a potential alternative to quartz sand in RPC in combination with nanomaterials to produce temperature‐resistant concrete structures.
Appraisal and Simulation on Codynamics of Pneumonia and Meningitis with Vaccination Intervention: From a Mathematical Model Perspective
Authors: Kotola Belela Samuel , Gebru Dawit Melese , Alemneh Haileyesus Tessema
Published: November 2022

The membranes that encompass the brain and spinal cord become inflamed by the potentially fatal infectious disease called pneumococcal meningitis. Pneumonia and meningitis “coinfection” refers to the presence of both conditions in a single host. In this work, we accounted for the dynamics of pneumonia and meningitis coinfection in communities by erroneously using a compartment model to analyze and suggest management techniques to stakeholders. We have used the next generation matrix approach and derived the effective reproduction numbers. When the reproduction number is less than one, the constructed model yields a locally asymptotically stable disease-free equilibrium point. Additionally, we conducted a sensitivity analysis to determine how different factors affected the incidence and transmission rate, which revealed that both the pneumonia and meningitis transmission rates are extremely sensitive. The performance of our numerical simulation demonstrates that the endemic equilibrium point of the pneumonia and meningitis coinfection model is locally asymptotically stable when

max

 

R

1

,

R

2

>
1

. Finally, as preventative and control measures for the coinfection of pneumonia and meningitis illness, the stakeholders must concentrate on reducing the transmission rates, reducing vaccination wane rates, and boosting the portion of vaccination rates for both pneumonia and meningitis.
Modeling of an Electrical Energy Switching System in Multisource Power Plants: The Case of Grid Connected Photovoltaic and Wind Power Systems
Authors: Louossi Theodore , Mbakop Fabrice Kwefeu , Dadje Abdouramani , Djongyang Noel
Published: November 2022

This paper proposes a multisource power plant management strategy for the proposed structure. This power plant consists of photovoltaic, wind, and grid. The principle of this management strategy is based on the reference currents and defines two components of the current namely a harmonic component related to the harmonics contained in the load current and current called fundamental related to the fundamental of the load current. This proposed strategy allows the different renewable sources to supply the load partially or totally. The harmonic component performs the power quality function while the fundamental component feeds the load and injects the surplus production into the grid. The power management is done according to the established scenarios and responds to the demand of the load. The simulations were carried out with Matlab software, and these results show the performance of this strategy for this structure studied to fulfill the following functions: power supply to the load, power factor (PF) correction, harmonic elimination, reactive energy compensation, and injection in the network of a current with a low rate of harmonic distortion lower than 1% in accordance with the IEEE Std 519-2014 standard.
The Oxygen Saturation Index as Early Predictor of Outcomes in Congenital Diaphragmatic Hernia
Authors: Horn-Oudshoorn Emily J.J. , Vermeulen Marijn J. , Knol Ronny , te Pas Arjan B. , Cochius-den Otter Suzan C.M. , Schnater J. Marco , Reiss Irwin K.M. , DeKoninck Philip L.J.
Published: November 2022

Objective: The aim of the study was to evaluate the oxygen saturation index (OSI) as an early predictor of clinical deterioration in infants with congenital diaphragmatic hernia (CDH). Methods: A single-center retrospective cohort study was conducted in consecutive infants with isolated CDH with continuous OSI measurements collected in the first 24 h after birth between June 2017 and July 2021. Outcomes of interest were pulmonary hypertension, extracorporeal membrane oxygenation (ECMO)-therapy, and mortality. We evaluated the discriminative values of the maximum OSI value and of mean OSI values with receiver operator characteristic (ROC) analysis and the area under the ROC curve. Results: In 42 infants with 49,473 OSI measurements, the median OSI was 5.0 (interquartile range 3.1–10.6). Twenty-seven infants developed pulmonary hypertension on a median of day 1 (1-1), of which 15 infants had an indication for ECMO-therapy, and 6 infants died. Maximum OSI values were associated with pulmonary hypertension, ECMO-therapy, and mortality. Mean OSI values had an acceptable discriminative ability for pulmonary hypertension and an excellent discriminative ability for ECMO-therapy and mortality. Although OSI measurements were not always present in the first hours after birth, we determined discriminative cut-offs for mean OSI values already in these first hours for pulmonary hypertension, the need for ECMO-therapy, and mortality. Conclusions: Continuous OSI evaluation is a promising modality to identify those infants at highest risk for clinical deterioration already in the first hours after birth. This provides an opportunity to tailor postnatal management based on the individual patient’s needs.
Ophthalmomyiasis Externa due to Oestrus ovis Larvae: A Case Report
Authors: Schrecker Jens , Ahnert Rebecca
Published: November 2022

A 23-year-old female presented with redness, itchiness, tearing, and foreign body sensation in her right eye after spending her holiday in Egypt. Slit lamp examination revealed about 15 mobile, whitish maggots that were microbiologically classified as Oestrus ovis larvae. All parasites could be removed without subsequent complications.
Aortic Distensibility Measured by Automated Analysis of Magnetic Resonance Imaging Predicts Adverse Cardiovascular Events in UK Biobank
Authors: Cecelja Marina , Ruijsink Bram , Puyol‐Antón Esther , Li Ye , Godwin Harriet , King Andrew P. , Razavi Reza , Chowienczyk Phil
Published: November 2022

Background

Automated analysis of cardiovascular magnetic resonance images provides the potential to assess aortic distensibility in large populations. The aim of this study was to compare the prediction of cardiovascular events by automated cardiovascular magnetic resonance with those of other simple measures of aortic stiffness suitable for population screening.

Methods and Results

Aortic distensibility was measured from automated segmentation of aortic cine cardiovascular magnetic resonance using artificial intelligence in 8435 participants. The associations of distensibility, brachial pulse pressure, and stiffness index (obtained by finger photoplethysmography) with conventional risk factors was examined by multivariable regression and incident cardiovascular events by Cox proportional‐hazards regression. Mean (±SD) distensibility values for men and women were 1.77±1.15 and 2.10±1.45 (
P
<0.0001) 10
−3
mm Hg
−1
, respectively. There was a good correlation between automatically and manually obtained systolic and diastolic aortic areas (
r
=0.980 and
r
=0.985, respectively). In regression analysis, distensibility associated with age, mean arterial pressure, heart rate, weight, and plasma glucose but not male sex, cholesterol or current smoking. During an average follow‐up of 2.8±1.3 years, 86 participants experienced cardiovascular events 6 of whom died. Higher distensibility was associated with reduced risk of cardiovascular events (adjusted hazard ratio [HR], 0.61 per log unit of distensibility;
P
=0.016). There was no evidence of an association between pulse pressure (adjusted HR 1.00;
P
=0.715) or stiffness index (adjusted HR, 1.02;
P
=0.535) and risk of cardiovascular events.

Conclusions

Automated cardiovascular magnetic resonance‐derived aortic distensibility may be incorporated into routine clinical imaging. It shows a similar association to cardiovascular risk factors as other measures of arterial stiffness and predicts new‐onset cardiovascular events, making it a useful tool for the measurement of vascular aging and associated cardiovascular risk.
“Noel Baba Adam Değildir”: Türkiye’de Yılbaşı Kutlamaları Üzerine Bir Değerlendirme
Authors: KUMTEPE Mehmet Akif
Published: November 2022

Türkiye’de her sene 31 Aralık tarihi yaklaştığında, yılbaşı kutlamaları tartışma konularının başlarında yer almaktadır. Kutlamalara karşı olan ve destekleyen taraflar benzer argümanlarla tartışmalara dahil olmaktadırlar. Bir taraf dinsel ve kültürel gerekçelerle yılbaşı kutlamalarının karşısında yer alırken; diğer taraf kutlamaların dinsel boyutunun olmadığını ve bunun basit bir eğlencenin ötesine geçmediğini savunmuşlardır. Ancak bu tartışmalar yapılırken ekonomik ilişkilerden kaynaklanan gerekçeler gözden kaçırılmaktadır. Çalışmada Türkiye’de yılbaşı kutlamalarının tarih içerisinde izlediği seyir ele alınmaya çalışılırken, kültürel, siyasal ve dinsel gerekçelerin yanı sıra ekonomik ilişkilerle de bağlantısı kurulmaya çalışılacaktır. Bu bağlamda 20-29 Aralık 2019 tarihlerinde düzenlenen Christmas Maket’in Türkiye’deki yılbaşı kutlamalarındaki dinsel ve kültürel tartışmalardan açık bir şekilde ayrıldığı düşünülmektedir. Bu doğrultuda, Türkiye’nin giderek muhafazakârlaştığı bir dönemde, önemli ölçüde Batılı kültürel değerleri barındıran ve bunu dile getiren Christmas Market’in nereye konulabileceği tartışma konusu yapılacaktır.
UKRAYNA KİMLİK İNŞASINDA POLONYA ETKİSİ VE GÜNÜMÜZE YANSIMALARI
Authors: SATYMOVA Sabina , KÖROĞLU Nergiz Özkural
Published: November 2022

Ukrayna kimliği çok derin ve uzun bir süreç içerisinde yapılanmıştır. Ukrayna, Polonya (Lehistan- Litvanya Birliği dönemi) ve Rusya (1772-1795 arası Rusya İmparatorluk dönemi) topraklarına dâhil olmuş ve bu dönemlerde Ukrayna kimlik inşa süreci üzerinde söz konusu devletler belirli etkiler bırakmıştır. Bu makalede tarihsel süreç içerisinde Polonya-Ukrayna ilişkileri ve söz konusu ilişkilerin Ukrayna kimlik inşa sürecindeki etkileri ele alınacaktır. Ukrayna kimlik inşa sürecinde Polonya’nın etkisi bağlamında önemli olan unsurlar belirlendikten sonra geçmişten günümüze bu unsurlar nasıl oluştu bunlar detaylandırılarak günümüz siyasetine ışık tutulmaya çalışılacaktır. Bağımsızlık sonrası Ukrayna’da meydana gelen siyasi gelişmelerinde (Turuncu Devrim, Meydan Devrimi gibi) Polonya’nın tutumu ve söz konusu dönemde Ukrayna-Polonya ilişkilerin gelişmesi incelenecektir. Son olarak, günümüzün Ukrayna Cumhurbaşkanı Volodymyr Zelensky dış siyaseti Ukrayna-Polonya ilişkileri çerçevesinde değerlendirilecektir.
Template-based Abstractive Microblog Opinion Summarization
Authors: Bilal Iman Munire , Wang Bo , Tsakalidis Adam , Nguyen Dong , Procter Rob , Liakata Maria
Published: November 2022

We introduce the task of microblog opinion summarization (MOS) and share a dataset of 3100 gold-standard opinion summaries to facilitate research in this domain. The dataset contains summaries of tweets spanning a 2-year period and covers more topics than any other public Twitter summarization dataset. Summaries are abstractive in nature and have been created by journalists skilled in summarizing news articles following a template separating factual information (main story) from author opinions. Our method differs from previous work on generating gold-standard summaries from social media, which usually involves selecting representative posts and thus favors extractive summarization models. To showcase the dataset’s utility and challenges, we benchmark a range of abstractive and extractive state-of-the-art summarization models and achieve good performance, with the former outperforming the latter. We also show that fine-tuning is necessary to improve performance and investigate the benefits of using different sample sizes.
Neuron-level Interpretation of Deep NLP Models: A Survey
Authors: Sajjad Hassan , Durrani Nadir , Dalvi Fahim
Published: November 2022

The proliferation of Deep Neural Networks in various domains has seen an increased need for interpretability of these models. Preliminary work done along this line, and papers that surveyed such, are focused on high-level representation analysis. However, a recent branch of work has concentrated on interpretability at a more granular level of analyzing neurons within these models. In this paper, we survey the work done on neuron analysis including: i) methods to discover and understand neurons in a network; ii) evaluation methods; iii) major findings including cross architectural comparisons that neuron analysis has unraveled; iv) applications of neuron probing such as: controlling the model, domain adaptation, and so forth; and v) a discussion on open issues and future research directions.
The survival of the optative in New Testament Greek
Authors: Bianconi Michele , Magni Elisabetta
Published: November 2022

This article offers new insights on the status of the optative in New Testament Greek, mapping it against the diachronic encoding of modality in Ancient Greek in light of typology and pragmatics. Virtually all available scholarship on the subject focusses on the ‘decline’ of the optative; in this article, we choose to focus on its survival in fixed expressions and specific types of speech acts. Through a comprehensive reanalysis of the New Testament data, we argue that the optative is ‘pushed out’ of the strict domain of modality and syntax and into that of illocution and pragmatics. Evidence from ancient grammatical thought, sociolinguistics, and language contact corroborates this view.
“And Every Language that Has Been Voiced Became a Millet”: A Genealogy of the late Ottoman Millet
Authors: Sigalas Nikos
Published: November 2022

This article outlines the history of the polysemous word millet from early Ottoman times up to the reign of Mahmud ii (r. 1808–39), challenging the view that the Ottoman term millet had an exclusively religious meaning before the nineteenth century. In the early Ottoman era, millet had at least three different meanings: in theological discourse, it was used as an abstract concept related to dīn and sharīʿa; when pertaining to religious groups, it meant “a people shaped through belief”; and, in a more vernacular register, it was used in the sense of “a people”. The article examines how these meanings shifted over the longue durée of Ottoman history. In the process, it addresses major social, political, and cultural changes that affected the sociolinguistics of Ottoman Turkish: the development of an elaborate imperial language grounded on shariatic ethics from the mid-sixteenth century; the Ottoman Porte’s growing acquaintance with Westphalian diplomacy from the early eighteenth century; and the development of an Ottoman confessional policy from the mid-eighteenth century, notably under Mahmud ii. I conclude that the meaning of millet in two registers has shifted in modern times to the modern concepts of “nation” and “confession”, thereby combining two arguably antithetical aspects of Ottoman secularisation in one polysemous word.
Covid-19, Fatwas, and Socio-religious Praxis
Authors: Nubowo Andar
Published: November 2022

This paper highlights Muhammadiyah’s religious and social engagement and praxis in dealing with the pandemic in Indonesia. As Indonesia’s largest modernist Islamic organisation with approximately 30 million members, Muhammadiyah has been challenged to prove its progressive understanding of Islam during the COVID-19 pandemic. Since March 2020, the organisation has issued religious fatwas and policies to adjust their worship and social activities during the outbreak. However, conservative elements oppose these fatwas and policies by stating that Covid-19 is a global conspiracy to destroy Islam. Through its networks and resources, Muhammadiyah keeps issuing fatwas to boost public awareness of the virus’s dangers and mortality and protect and save lives. Thus, the paper seeks to discover why and how the organisation adopts new practices in their rituals and new sites of worship and, at the same time, fights against religious ignorance and hoaxes around the Covid-19. It also seeks to determine how Muhammadiyah mobilises its networks and resources to deal with the outbreak and opposition. Finally, it examines the organisation’s relationship with state and non-state actors, nationally and internationally, to face the impacts of such a contagious virus. Drawing upon Muhammadiyah’s official fatwas, policies, statements, and socio-religious praxis, this paper finds that Muhammadiyah’s social mission, caring, and engagement during the pandemic are based on its progressive and rational belief system.
Victory in the Time of COVID
Authors: Bauman Chad
Published: November 2022

The global COVID-19 pandemic of 2020–2021 required significant ritual adjustment in churches worldwide, particularly the larger ones. It has also provoked theological reflection on the origins on the virus, as well as on what God’s Word had to say in response. This article investigates the adjustments and reflections at one Indian megachurch, Bangalore’s Full Gospel Assembly of God (FGAG), with special reference to its utilization of a victory-oriented and defiant gospel of divine care, protection, and health. The question that animates this investigation is: Can a gospel of victory and health survive a global pandemic? The answer, somewhat counterintuitively (but in another sense – for those familiar with prosperity theology – not at all) is that it not only survives, but thrives. The article attempts to account for this thriving with reference to two distinctive characteristics of the soft version of the prosperity gospel that are manifest in FGAG’s victory gospel, both of which are inculcated through ritual repetition and performance: 1) Its paradoxically simultaneous insistence that the faithful are, by God, already victorious, and that miraculous reversals await those who aren’t, and 2) its boldly defiant response to evidence that all is not well..
Refocusing Body, Mind and Community Interconnections
Authors: Fisker-Nielsen Anne Mette
Published: November 2022

This paper explores responses to COVID-19 by the Buddhist organisation Soka Gakkai in Japan. Sōka means ‘value-creation’, but what kind of ‘value’ was created amidst a global pandemic? So-called ‘new religions’ in the context of Japan are typically presumed to embody a ‘flight from the human world’ into the exotic and remote. SG’s response, however, encouraged people to stay very much within a ‘human-bound world’. How did SG differ compared to other popular responses in Japan that drew on yōkai (or ‘spirits’) for comfort in defeating the soon objectified virus ‘monster’? SG may be well-built for responding to disaster in its extensive grassroots networks and its daily newspaper to provide information. Responding with a renewed focus on study, chanting and outreach also highlights, however, how the meaning of ‘hope’ and ‘well-being’ were generated by internal change while structurally working to realise the SDG s as part of more long-term solutions.
Three new species of Ancyronyx Erichson, 1847 (Coleoptera, Elmidae) from Mindanao, Philippines
Authors: Seno Christalle Beatriz N. , Delocado Emmanuel D. , Freitag Hendrik
Published: November 2022

Three new species of the genus Ancyronyx Erichson, 1847 from Greater Mindanao are described: A. kalasan sp. n., A. manobo sp. n., and A. zamboangaensis sp. n. Illustrations of habitus and line drawings of genitalia are presented. Molecular species delimitation using COI mtDNA barcodes supports the morphological species concept.
Madhuca kanchanaburiensis (Sapotaceae), a new species from Thailand
Authors: CHANTARANOTHAI PRANOM , KUNASIT PONGSAKORN , KLADWONG PORNCHAI
Published: November 2022

A new species of Madhuca from Thailand, M. kanchanaburiensis is described and illustrated. The species appears most similar to M. malaccensis and M. punctata, but differs in having conspicuous secondary veins toward the leaf margin, woolly filaments and longer corolla. The vernacular name and conservational status of this endemic species are also provided.
Asplenium coronatum (Aspleniaceae), a new fern species from the Brazilian Atlantic Forest
Authors: REIS ATILES , LINO VANESSA , MASSI MYNSSEN CLAUDINE , DA SILVA SYLVESTRE LANA
Published: November 2022

A new fern species, Asplenium coronatum (Aspleniaceae), endemic to the Atlantic Forest is described. This species belongs to the Asplenium serratum complex, which comprises species that have simple, entire laminae with free veins ending near the margin and no marginal vein. Asplenium coronatum is distinguished from A. serratum by its large scales, which are often more than 20 mm long and have regularly thick cell walls, and laminae with an irregular, entire to slightly crenulate margin and acute to acuminate-caudate apex, commonly bearing a proliferous tip.
On some species of Zygophylax Quelch, 1885 (Cnidaria: Hydrozoa: Zygophylacidae) from off New Caledonia
Authors: GALEA HORIA R. , MAGGIONI DAVIDE , GALLI PAOLO
Published: November 2022

Eleven species of hydroids belonging to the genus Zygophylax Quelch, 1885 are present in the material collected by the KANACONO, KANADEEP and KANADEEP 2 expeditions of the French Tropical Dee-Sea Benthos Program. Of these, ten represent known taxa and are fertile specimens, while the last one is unidentifiable in the absence of its gonosome. Seven species are new records for the study area. Zygophylax dispersa Peña Cantero, 2020 is assigned to the synonymy of Z. pseudafricana Vervoort & Watson, 2003, while Z. laertesi Peña Cantero, 2020 is comprehensively redescribed based on numerous and morphologically-varied specimens. Uncertainties exist as to the synonymy between Z. antipathes (Lamarck, 1816) and Z. rufa (Bale, 1884), but the oldest available binomen was nevertheless used. The presence of nematothecae is confirmed in Z. polycarpa Vervoort & Watson, 2003, a species with unusual gonothecae for the genus, now redescribed based on additional, abundant material. Zygophylax pseudosibogae Gu et al., 2022 is also redescribed, supplementing the original account. Finally, phylogenetic analyses, based on the 16S rRNA gene, allowed the genetic characterization of a total of twenty nominal species of Zygophylax, including sequences for eight taxa not considered so far. The number of Zygophylax species known from the New Caledonian area is raised from eight to sixteen.
Incidental Thyroid Carcinoma Identified by Positron Emission Tomography Scanning Obtained for Metastatic Evaluation
Authors: Davis Peyton W. , Perrier Nancy D. , Adler Lee , Levine Edward A.
Published: November 2022

Positron emission tomography (PET) scanning is an emerging technology with substantial implications for patients with solid tumors. PET is useful in identifying sites of metastatic disease as well as primary malignancy and evaluating suspicious findings found via other imaging modalities. PET is becoming a standard modality for metastatic evaluation of a variety of malignancies. However, this imaging is not limited by histology and may reveal clinically occult second lesions. We present five cases of a clinically occult thyroid cancer found in patients who underwent PET scanning for metastatic evaluations. The principal diagnoses included two patients with malignant melanoma, one each with gastric, rectal, and colonic adenocarcinoma. None of the cases had findings on physical examination. Increased uptake in the region of the thyroid was evident on the PET scan, and fine-needle aspiration biopsy indicated papillary carcinoma of the thyroid in all five cases. Although evaluation of metastatic disease is the primary purpose for PET in this setting the discovery of occult thyroid malignancy is an additional benefit of such imaging. This emphasizes the importance of investigating suspicious areas found by PET and not simply assuming that these are all sites of metastatic disease. Furthermore incidental findings of uptake in the region of the thyroid make consideration of a primary carcinoma mandatory.
Consequences of aberrated DNA methylation in Colon Adenocarcinoma: a bioinformatic-based multi-approach
Authors: Moradi Arash , Shahsavari Milad , Gowdini Erfan , Mohammadian Kamal , Alizamir Aida , Khalilollahi Mohammad , Abgarmi Zahara Mohammadi , Ganji Shahla Mohammad
Published: November 2022

Introduction

The biology of colorectal cancer (CRC) is remained to be elucidated. Numerous genetic and epigenetic modifications are in concert to create and progress CRC. DNA methylation as a principal epigenetic factor has gained increased attention and could be utilized for biological studies. This study aims to find novel methylated and downregulated genes with a focus on HAND2 in CRC and decipher the biological consequences.

Material and method

Data on DNA methylation from GEO and SMART databases and the expression GEPIA2 database were downloaded. Afterward, a set of hypermethylated and downregulated genes in CRC was chosen by overlapping genes. Consequently, HAND2 was selected as a key gene for further investigation and confirmed with cell lines methylation and expression data. The functions of HAND2 were further analyzed using gene ontology analyses and the protein–protein interaction network.

Results

The methylation (p < 0.01) and expression (p < 0.01) of HAND2 are significantly varied in CRC compared to normal control. The correlation analysis (Pearson's correlation coefficient = -0.44, p = 6.6e-14) conveys that HAND2 significantly downregulated and has a reverse correlation with the methylation status of CpG islands. The biological process analysis of HAND2 target genes conveyed that disruption in HAND2 expression could dysregulate ERK1 and ERK2 signaling pathways.

Conclusion

Together, the findings showed that DNA hypermethylation of HAND2 was critical evidence in CRC. Further validation and prospective studies are needed to utilize HAND2 methylation as a promising biomarker.