bluuebunny/crossref_metadata_2025 huggingface dataset:
PELATIHAN SOCIAL MEDIA STORYTELLING UNTUK WARGA DAN KOMUNITAS ADAT BEKERJA SAMA DENGAN PERKUMPULAN TERAS MITRA
Authors: Nasrullah Nasrullah , Wijaya Taufan , Veronika Veronika , Bintang Samiaji , Wardhana Aditya Heru
Published: November 2024

Technology can support the dissemination and exchange of information to encourage increased welfare and economic independence of residents in the village. The Community Service Team (PKM) Multimedia Nusantara University collaborates with the Teras Mitra association with the aim of encouraging the use of the internet and social media in governance, production, and knowledge distribution and local wisdom of village communities. Teras Mitra was chosen as a partner because of the association's reputation for assisting the empowerment of 60 villages in Indonesia. PKM lasts for nine months (March-December 2021), at the initial stage it is agreed to organize a podcast training. There were 19 participants representing communities in Bali, Kupang, Pontianak, Banyumas, Bogor, Wakatobi, Bantul, Karanganyar, Lombok, Kab. Bandung, Solo, Mojokerto. The training lasted for four meetings. The training activity begins with an introduction to the platform that will be used and its current potential. In the second session, participants learned to look for podcast ideas and then the design stage. In the third session, participants trained their vocal skills to maximize podcast production and practiced audio editing. In the last session, participants presented the podcast they produced and received input. The trainees gain knowledge and skills in storytelling. The result of the training is a podcast uploaded on the Sportify platformAbstract in bahasaTeknologi dapat mendukung penyebaran dan pertukaran informasi untuk mendorong peningkatan kesejahteraan dan kemandirian ekonomi penduduk di desa. Tim Pengabdian Kepada Masyarakat (PKM) Universitas Multimedia Nusantara berkolaborasi dengan perkumpulan Teras Mitra dengan tujuan mendorong pemanfaatan internet dan media sosial dalam tata kelola, produksi, hingga distribusi pengetahuan dan kearifan lokal komunitas desa. Teras Mitra dipilih sebagai rekan karena reputasi perkumpulan ini yang mendampingi pemberdayaan 60 desa di Indonesia. PKM berlangsung selama sembilan bulan (Maret-Desember 2021), di tahap awal disepakati penyelenggaraan pelatihan siniar (podcast). Ada 19 peserta perwakilan komunitas di Bali, Kupang, Pontianak, Banyumas, Bogor, Wakatobi, Bantul, Karanganyar, Lombok, Kab. Bandung, Solo, Mojokerto. Pelatihan berlangsung selama empat pertemuan. Kegiatan pelatihan dimulai dengan pengenalan platform yang akan digunakan dan potensinya saat ini. Sesi kedua, peserta belajar mencari ide podcast kemudian tahap perancangannya. Sesi ketiga peserta melatih kemampuan vokalnya untuk memaksimalkan produksi podcast serta berlatih editing audio. Sesi terakhir peserta melakukan presentasi podcast yang diproduksi dan mendapatkan masukan. Peserta pelatihan mendapat pengetahuan dan keahlian dalam bercerita. Hasil pelatihan adalah podcast yang diunggah di platform Sportify.
USAHA KECIL KRUPUK IKAN GABUS DI DUSUN SUMBER REJO DUKUH KAUMAN SURABAYA
Authors: Kartika Chandra , Chamariyah Chamariyah , Sarie Rena Febrita
Published: November 2024

The purpose of this activity is to help business actors of Krupuk Ikan Gabus SME Partners to provide understanding to business actors about the factors supporting business activities, namely legality and business management factors so that the business activities carried out are not only profit-oriented. The target of PPM activities in this snakehead fish product partner is to make employee SOPs, training on making simple financial reports, making new krupuk packaging, helping digital marketing so that revenue increases, coaching and training employees for hygenic product production, training and coaching management in inventory and good business management, helping to create logos, media banners and pamlets for advertising. The method applied in this PPM activity is through business mentoring techniques including partner mindset coaching, business capital assistance online marketing training, training and financial report coaching, product promotion assistance, quality and quality krupuk production assistance, business management training, and training on selecting the most desired krupuk flavor. The results of the activities can increase the income and productivity of this group of community partners higher before, significantly understand the business well, ranging from good production, very fast sales and digital marketing as well as an increase in hygenic knowledge in the management of this krupuk product.abstract in bahasaTujuan dari kegiatan ini adalah untuk membantu pelaku usaha Mitra UKM Krupuk Ikan Gabus untuk memberikan pemahaman kepada pelaku usaha mengenai faktor-faktor pendukung kegiatan usaha yaitu faktor legalitas dan manajemen usaha sehingga kegiatan usaha yang dilakukan tidak hanya berorientasi pada profit. Target kegiatan PPM di mitra produk ikan gabus ini adalah membuat SOP karyawan, pelatihan pembuatan laporan keuangan sederhana, pembuatan kemasan krupuk baru, membantu digital marketing sehingga pendapatan meningkat, pembinaan dan pelatihan karyawan untuk produksi produk hygenic, pelatihan dan pembinaan manajemen dalam inventory dan manajemen bisnis yang baik, membantu membuat logo,  spanduk media dan pamlet untuk iklan. Metode yang diterapkan dalam kegiatan PPM ini adalah melalui teknik pendampingan usaha meliputi pembinaan pola pikir mitra, pendampingan modal usaha pelatihan pemasaran online, pelatihan dan pembinaan laporan keuangan, pendampingan promosi produk, bantuan produksi krupuk yang berkualitas dan berkualitas, pelatihan manajemen usaha, dan pelatihan pemilihan rasa krupuk yang paling diinginkan. Hasil kegiatan dapat meningkatkan pendapatan dan produktivitas kelompok mitra masyarakat ini lebih tinggi sebelumnya, secara signifikan memahami bisnis dengan baik, mulai dari produksi yang baik, penjualan yang sangat cepat dan pemasaran digital serta peningkatan ilmu hygenis dalam pengelolaan produk krupuk ini.
DISEMINASI PERKEMBANGAN TEKNOLOGI ASPAL DALAM SEMINAR “ASPHALT DAY 2022”
Authors: Daniel Christian Gerald , Purba Sadvent Martondang
Published: November 2024

Kegiatan seminar Asphalt Day 2022 ini dibuat dalam dua tahap. Sesi pertama diadakan di tanggal 27 Januari 2022 bekerja sama dengan PT. Enceha Pacific dan Nouryon Southeast Asia mengangkat topik pengantar mengenai teknologi aspal, sedangkan sesi kedua diselenggarakan di tanggal 30 November 2022 dengan mengajak PT. Buntara Megah Inti, PT. Jaya Konstruksi Manggala Pratama serta Iterchemica untuk bersama-sama membagikan materi mengenai aspal modifikasi polimer dan aspal rekayasa daur ulang. Seminar tahap pertama diikuti oleh 217 orang dan mengalami peningkatan hingga 23.5% di tahap kedua dengan rata-rata peserta berasal dari kontraktor, dan parameter kesuksesan acara ini diukur dari hasil survei yang diberikan ke peserta. Survei menunjukkan bahwa tingkat kepuasan akan acara dan materi yang dibawakan mencapai lebih dari 90%, dengan materi yang dibawakan dianggap sangat relevan dengan kebutuhan professional peserta, secara khusus pada topik kajian teoritis aspal modifikasi polimer dan aspal daur ulang.
EDUKASI KESEHATAN REPRODUKSI DAN GERAKAN SADARI KEPADA REMAJA PUTRI DI SMA NEGERI 5 DEPOK
Authors: Lestari Bonieta Dwi , Samaria Dora , Febriani Nelly , Rahma Annisa , Meta Melani , Izza Nurul , Apriliana Vionita
Published: November 2024

Adolescence or childhood to adulthood is a condition characterized by the maturation of reproductive organs and functions. In adolescent girls, it is marked by the first menstruation (menarche), and also secondary signs such as the introduction of breast cells that must be handled optimally so that it does not lead to something undesirable such as breasts. Therefore, activities are needed to identify factors of adolescent knowledge and health education to equip their reproductive health knowledge. Thus, the purpose of this activity is to analyze the knowledge factor about the reproductive system of adolescent girls at SMAN 5 Depok, followed by a demonstration of the Breast Self-Examination (BSE). The method of activity is carried out offline, using a pre-experimental design with a one group pre-test post-test design. In addition, a simulation of SADARI examination per group was carried out using phantom breasts. From the PKM that has been carried out, it is found that there is an increase in knowledge related to the reproductive system in adolescents and the introduction of SADARI, and is supported by the acquisition of significant pretest and posttest score.abstract in bahasaRemaja atau masa peralihan anak-anak menuju dewasa adalah suatu kondisi yang ditandai dengan matangnya organ dan fungsi reproduksi. Pada remaja wanita ditandai dengan menstruasi pertama (menarche), dan juga tanda-tanda sekunder seperti pembesaran sel-sel payudara yang harus dirawat secara maksimal agar tidak tidak mengarah ke suatu hal yang tidak diinginkan seperti kanker payudara. Oleh karena itu, diperlukan kegiatan untuk mengidentifikasi faktor pengetahuan remaja dan edukasi kesehatan untuk membekali pengetahuan kesehatan reproduksi mereka. Dengan demikian, tujuan kegiatan ini adalah untuk menganalisis faktor pengetahuan mengenai sistem reproduksi remaja putri di SMAN 5 Depok, diikuti dengan pendemonstrasian gerakan Periksa Payudara Sendiri (SADARI). Dengan adanya kegiatan pengabdian masyarakat (PKM) ini diharapkan dapat meningkatkan pengetahuan para remaja putri di SMAN 5 Depok tentang sistem reproduksi khususnya menstruasi dan kanker payudara. Metode kegiatan dilakukan secara luring, menggunakan rancangan one group pretest and posttest design. Selain itu, simulasi pemeriksaan SADARI per kelompok dilakukan dengan menggunakan phantom payudara. Dari PKM yang telah dilaksanakan didapatkan hasil bahwa ada peningkatan pengetahuan terkait sistem reproduksi wanita pada remaja dan pengenalan SADARI, dan pernyataan ini didukung oleh perolehan score pretest dan posttest yang signifikan.
PELATIHAN PEMBUATAN BAHAN AJAR KURIKULUM MERDEKA BAGI GURU DI SMP FELLYCIA
Authors: Martha Kurniawati , Sianipar Lia , Izaak Maya Puspitasari , Gunanto Yohanes Edi , Sitompul Henni
Published: November 2024

Kurikulum Merdeka memiliki konsep kurikulum yang menuntut kreatifitas guru di mana guru sebagai pendidik memiliki keleluasaan untuk merancang modul ajar yang disesuaikan dengan karakteristik peserta didik, kebutuhan peserta didik dan ketersediaan sarana prasarana yang dimiliki sekolah. Adapun tujuan dari Kurikulum Merdeka adalah untuk menjawab tantangan pendidikan di era revolusi industri 4.0 dalam menyiapkan generasi muda agar dapat berkontribusi dan menghadapi tantangan di era globalisasi. Oleh karena itu, guru memerlukan kemampuan untuk merancang bahan ajar yang di dalamnya terdapat komponen-komponen seperti tujuan pembelajaran, langkah pembelajaran, penilaian dan media pembelajaran. Berdasarkan analisis kebutuhan yang dilakukan, didapati guru-guru di SMP Fellycia belum sepenuhnya memahami konsep Kurikulum Merdeka. Hal ini menyebabkan guru-guru memiliki kesulitan dalam membuat, memodifikasi, dan mengembangkan modul ajar.Untuk mengatasi permasalahan tersebut, tim memberikan pelatihan pembuatan bahan ajar dengan berdasarkan pada Kurikulum Merdeka. Tujuan kegiatan PKM adalah membekali guru SMP Fellycia agar dapat membuat bahan ajar, memodifikasi, dan mengembangkan berdasarkan pada Kurikulum Merdeka. Metode pelatihan adalah dengan ceramah, tanya jawab, brainstorming, dan presentasi peserta. Hasil kegiatan PkM adalah 71% guru-guru di SMP Fellycia dapat memahami esensi dari Kurikulum Merdeka dan dapat membuat, memodifikasi, dan mengembangkan bahan ajar Kurikulum Merdeka Belajar.
IMPROVING DATA LITERACY AMONG JOURNALISTS THROUGH WORKSHOP AND CONFERENCE TO ADVANCE THE ANALYTICAL SKILLS IN REPORTING
Authors: Kusumawati, Setianto Utami, Yearry Diah, Panji
Published: November 2024

In an extraordinary situation such as pandemic and disaster, journalists perform a beneficial function in presenting accurate and reliable information. Information is passed on to the public who are in dire need of guidance during an emergency situation especially when the public is overloaded with unreliable information. Therefore, journalists have an obligation to present truth and eliminate disinformation by providing fact-based storytelling to the public as stated in one of the elements of journalism. The practice of data journalism has become popular as we are becoming more familiar with the presence of data as well as the development of technology. Thus, improving data literacy among journalists has become essential. The creation of Data and Computational Journalism Conference and Workshop Indonesia (DCJ-CI) 2022 aims to enhance the data skills of journalists nationwide by presenting a series of hands-on workshops, talk shows, seminars, and networking sessions to journalists, journalism students and lecturers, as well as data enthusiasts in Indonesia. This event was attended by hundreds of participants throughout the country and joined by speakers and experts from countries like U.S., England, India, Singapore, Nepal, and Indonesia. DCJ-CI resulted in data journalism and computational products published in several media in Indonesia.
ANALISIS NON-PARAMETRIK TERHADAP FAKTOR-FAKTOR YANG MEMENGARUHI DETAK JANTUNG MAKSIMUM DI DALAM INDUSTRI KESEHATAN [NON-PARAMETRIC ANALYSIS OF FACTORS INFLUENCING MAXIMUM HEART RATE IN THE HEALTHCARE SECTOR]
Authors: Tanubrata Nicholas Andrew , Sambow William Samuel , Christian Jonathan , Ferdinand Ferry Vincenttius
Published: November 2024

This study aims to analyze factors that influence maximum heart rate using a non-parametric statistical analysis approach, which is flexible in analyzing data with unknown or non-normal distributions. Factors analyzed include resting electrocardiogram (ECG) examination results, type of chest pain, and blood pressure. Respondents were classified based on these factors to facilitate analysis. Methods used in this study included the Expanded Median Test (K-Sample), Pearson Correlation Test, and Kruskal-Wallis Test, which were chosen because they were appropriate for the type of data and the objectives of the study that involved testing the median between multiple groups. Results showed that ECG and chest pain type significantly influenced maximum heart rate, while blood pressure did not show a significant effect. The main contribution of this study is that it provides an empirical basis for detecting modifiable cardiovascular risk factors, supporting heart attack prevention efforts through early detection, and directing further research for a more comprehensive analysis.

Bahasa Indonesia Abstract:

Penelitian ini bertujuan untuk menganalisis faktor-faktor yang memengaruhi detak jantung maksimum menggunakan pendekatan analisis statistik non-parametrik, yang fleksibel dalam menganalisis data dengan distribusi yang tidak diketahui atau tidak normal. Faktor yang dianalisis meliputi hasil pemeriksaan elektrokardiogram (EKG) istirahat, tipe nyeri dada, dan tekanan darah. Responden diklasifikasikan ke dalam kelompok risiko berdasarkan faktor-faktor ini untuk memudahkan analisis. Metode yang digunakan dalam penelitian ini mencakup Perluasan Uji Median (K-Sampel), Uji Korelasi Pearson, dan Uji Kruskal-Wallis, yang dipilih karena sesuai dengan jenis data dan tujuan penelitian yang melibatkan pengujian median antara beberapa kelompok. Hasil menunjukkan bahwa EKG dan tipe nyeri dada secara signifikan memengaruhi detak jantung maksimum, sedangkan tekanan darah tidak menunjukkan pengaruh signifikan. Kontribusi utama penelitian ini adalah memberikan dasar empiris untuk mendeteksi faktor risiko kardiovaskular yang dapat dimodifikasi, mendukung upaya pencegahan serangan jantung melalui deteksi dini, dan mengarahkan penelitian lanjutan untuk analisis yang lebih komprehensif.
Problems Faced by Judges in Determining Rehabilitation for Narcotics Abusers
Authors: Tobing Christina Natal Megawati , Hutapea Tumbur Palti D.
Published: November 2024

Addicts and victims of narcotic abuse should be placed in medical and social rehabilitation institutions. However, in empirical practice in the field, judges rarely exercise their powers to dive into a drug abuser accused of being brought to court through an assessment instrument. An assessment is needed to determine whether the defendant has a network of dealers or is just an addict or victim of narcotics abuse. The focus of this research problem is the obstacle for judges in determining the implementation of rehabilitation for narcotics abusers. The purpose is to identify the judge, in his decision, can determine medical rehabilitation for drug abusers in accordance with the mandate of the law. This research uses normative legal method based on positive legal studies with secondary data. The judge can consider whether the assessment results from the Integrated Assessment Team (TAT) allow them to be attached to the case file. Even the results of the assessment can be equated with expert testimony, which is an expert opinion written in a letter.
O que não foi contado após a independência do Brasil
Authors: Teixeira Paulo Eduardo , Cunha Maísa Faleiros
Published: November 2024

Este artigo é fruto de pesquisa concluída que apontou as possíveis imbricações entre o crescimento populacional e a dinâmica demográfica (natalidade, mortalidade, migração e nupcialidade) verificados em dois municípios da Província de São Paulo, sobretudo após a independência do Brasil em 1822. À luz de processos socioeconômicos mais amplos, à localização geográfica, à disponibilidade de terras e de recursos naturais, analisamos as populações de pessoas livres e escravizadas em Campinas e Franca. As fontes utilizadas foram os registros paroquiais (batismo, óbito e casamento) e censos produzidos em São Paulo. Da análise resultante podemos destacar o papel dos fluxos migratórios no efetivo povoamento e as elevadas taxas de crescimento natural da população no período considerado.
Evaluasi Program Kawasan Sehat di Wilayah Layanan Kesehatan Cuma-Cuma Dompet Dhuafa Nusa Tenggara Barat dalam Upaya Pencegahan dan Penanganan Stunting
Authors: Samara Shafira Salsabila , Selawati Selawati , Sari Martina Tirta , Amelia Kurnia , Wisastra Danan Panggih , Khotibi Zulkarnaen
Published: November 2024

Latar Belakang: Masalah gizi anak masih menjadi isu kesehatan yang perlu diperhatikan, salah satunya stunting sebagai prioritas negara. Data Survei Status Gizi Indonesia menunjukkan kenaikan prevalensi stunting di Provinsi Nusa Tenggara Barat (NTB) dari 31,4% (2021) menjadi 32,7% (2022). Lembaga Dompet Dhuafa memiliki Program Kawasan Sehat yang membantu pemerintah dalam membangun pola hidup sehat masyarakat khususnya pencegahan stunting.
Tujuan: Mengevaluasi Program Kawasan Sehat dalam upaya pencegahan dan penanganan stunting di wilayah Layanan Kesehatan Cuma-Cuma NTB.
Metode: Penelitian evaluatif ini menggunakan metode campuran. Data dikumpulkan melalui wawancara, observasi, dan telaah dokumen. Informan dipilih dengan teknik purposive sampling. Analisis data kualitatif dilakukan dengan tahapan reduksi data, penyajian data, dan penarikan kesimpulan. Data kuantitatif dianalisis secara deskriptif untuk melihat prevalensi stunting dan capaian indikator program.
Hasil: Program Kawasan Sehat berkontribusi dalam upaya pencegahan dan penanganan stunting. Komponen input pada program tersebut mampu mendorong program berjalan dengan baik, dimana SDM dan anggaran tercukupi dengan adanya kemitraan. Komponen proses berjalan dengan sistematis mulai dari perencanaan yang melibatkan stakeholder, pelaksanaan dengan gabungan metode pemberdayaan masyarakat dan charity, serta pengawasan. Berbagai intervensi dilakukan mulai dari pendampingan ibu hamil, ibu menyusui, bayi dan balita. Keberhasihan output terlihat dari adanya penurunan prevalensi stunting di kawasan sehat NTB dan ketercapaian indikator program.
Kesimpulan: Keseluruhan program kawasan sehat terkait intervensi stunting sudah dapat dikatakan berhasil (input, proses, output). Penguatan pemberdayaan masyarakat harus selalu dilakukan sebagai upaya membiasakan masyarakat berperilaku hidup bersih dan sehat.
Dietary Intake, Lifestyle Factors, and Metabolic Risk: Insights from Health Check-Ups at a Private Healthcare Facility in Coimbatore, India
Authors: Dhandapani Shanthi , Afshan Kamar , Shreya Sesham , Vincy Catherine Lily , Yuvaraj V. , Krithika V.
Published: November 2024

Background: Over the last decade (2014–2024), the global prevalence of metabolic risk factors such as dyslipidemia (5-8%), hypertension (5-10%), obesity (10-15%) and elevated blood glucose levels (10-15%) has been steadily increasing.
Objectives: To determine the correlation among the dietary consumption, lifestyle factors, and metabolic risk factors among the respondent of age 18-65 years.
Methods: The respondent (n=419) were enrolled from August 2023 to February 2024 in Coimbatore, India. The sociodemographic characteristics, dietary intake, stress levels, and physical activity were measured using questionnaires. The respondent’s anthropometry, HbA1c level, blood pressure, and liver function tests were examined, and those with abnormal liver enzymes underwent abdominal ultrasonography for fatty liver diagnosis. The descriptive, Chi square and Kendall’s tau correlation coefficient were performed for statistical analysis.
Results: This research showed a weak correlation among protein intake of the respondent and obesity (r=0.084 and p-value=0.026). A significant association was observed among blood pressure range and the consumption of fat (r=0.079, p-value=0.039), protein (r=0.158, p-value<0.001). Correspondingly, the intake of nutrient such as energy (r=0.102, p-value<0.001), carbohydrate (r=0.089, p-value<0.001), and fat (r=0.156, p-value<0.001) was positively correlated with an increased hyperglycaemic risk. Further, energy (r=0.202, p-value<0.001), carbohydrate (r=0.146, p-value<0.001) consumption level had positive correlation with fatty liver disease.
Conclusions: A significant positive correlation as observed between and metabolic risk factors and dietary intake. Modifying the interventions to target these risk factors may aid lower the risk of hypertension, obesity, hyperglycaemia, and fatty liver disease in diverse inhabitants.
Konsumsi Makan dan Tingkat Pendapatan Keluarga dengan Kejadian Kekurangan Energi Kronik Pada Ibu Hamil di Wilayah Pesisir di Indonesia: Tinjauan Pustaka Sistematis
Authors: Ningtyias Farida Wahyu , Jamil Alifia Istnaini , Antika Ruli Bahyu
Published: November 2024

Latar Belakang: Defisit energi kronis (KEK) merupakan malnutrisi pada ibu hamil dan menjadi masalah gizi di Indonesia. KEK pada ibu hamil menyebabkan anemia, perdarahan, tidak teraturnya kenaikan berat badan ibu, dan infeksi. KEK dipengaruhi asupan konsumsi makanan, yang secara tidak langsung juga dipengaruhi oleh faktor budaya dan tingkat pendapatan keluarga. Ibu hamil yang tinggal di wilayah pesisir cenderung memiliki daya beli rendah.
Tujuan: Menganalisis hubungan antara pola konsumsi makan dan tingkat pendapatan keluarga dengan kejadian KEK selama kehamilan di wilayah pesisir berdasarkan hasil penelitian penulis lain.
Metode: Manuskrip ini merupakan hasil tinjauan literatur sistematis. Sumber data berasal dari PubMed, DOAJ, Garuda Portal, Proquest, dan Google Scholar mulai tahun 2013-2022. Kata kunci yang digunakan adalah  “Food Consumption” AND “Family Income” AND “Chronic Energy Deficiency Incidence” AND “Pregnancy in Coastal Areas”, AND “Socio-Cultural”, AND “Health Services”, AND “Food Access” dan menghasilkan 18  artikel. Prisma digunakan untuk seleksi dan menilai kualitas artikel.
Diskusi: Tiga belas dari 18 artikel yang dikaji hanya membahas satu variabel yaitu konsumsi makanan atau pendapatan keluarga dan lima jurnal membahas dua variabel yaitu konsumsi makanan dan pendapatan keluarga. Dua belas dari tiga belas artikel tersebut menyatakan terdapat hubungan yang signifikan antara konsumsi pangan dengan kejadian KEK pada kehamilan di wilayah pesisir dan satu artikel menyimpulkan hal sebaliknya. Ibu hamil di wilayah pesisir memiliki risiko lebih tinggi mengalami KEK karena rendahnya pendapatan keluarga dan kurangnya akses terhadap makanan bergizi.
Kesimpulan: Pencegahan KEK ibu hamil di wilayah pesisir dilakukan dengan meningkatkan pendapatan keluarga dan akses makanan bergizi yang mencukupi.
Levotiroksin Tedavisi Alan Ötiroid Hashimoto Hastalarında Tiroid Dışı Kanserler: Tek Bir Tersiyer Merkezin Hastalarına Bakış
Authors: Sezer Havva
Published: November 2024

Levotiroksin (LT4) tedavisi alan ötiroid Hashimoto hastalarında tiroid dışı kanser (TDK) sıklığını araştırmayı amaçladık. Ayrıca kanser gelişiminin demografik, klinik, biyokimyasal ve metabolik parametrelerle ilişkili olup olmadığını da belirledik. Aralık 2016 ile Aralık 2023 tarihleri arasında tek bir tersiyer merkezde Hashimoto tiroiditi (HT) kaynaklı hipotiroidi tanısı alan 18 yaş üzeri takipteki ardışık katılımcılar çalışmaya dahil edildi. Toplam 577 Hashimoto hastası retrospektif olarak analiz edildi. Çalışma popülasyonu TDK olup olmamasına göre iki alt gruba ayrıldı. Kanserli ve kansersiz hastalarda demografik, klinik, biyokimyasal ve metabolik parametreler karşılaştırıldı.Bulgular: Ortalama yaş 52,6±13,5 yıldı. Beş yüz yetmiş yedi hastanın %87,3'ü kadın, %12,7'si erkekti. HT’ne eşlik eden en sık iki komorbidite metabolik sendrom (%36,4) ve obezite (%31,2) idi. HT ile TDK’in birlikte görülme sıklığı %13,3 idi. En sık görülen iki kanser meme (%46,2) ve over (%8,7) oldu. Çok değişkenli analizde, ileri yaşın (OR 1,030, %95 CI 1,012-1,049, p=0,001), pozitif aile öyküsünün (OR 1,859, %95 CI 1,117-3,092, p=0,017) ve yüksek açlık kan şekerinin (OR) 1,022, %95 CI 1,007-1,037, p=0,005) artan kanser riski ile anlamlı pozitif korelasyona sahip olduğu bulunmuştur. Bu çalışma, LT4 tedavisi alan ötiroid Hashimoto hastalarında TDK sıklığının %13,3 olduğunu ortaya çıkardı. Meme kanseri, çalışma popülasyonunu etkileyen en yaygın kanserdi. İleri yaş, pozitif aile öyküsü ve yüksek açlık kan şekeri, kanser gelişimi için bağımsız risk faktörleri olarak tanımlandı.
Three-Dimensional Printing/Bioprinting and Cellular Therapies for Regenerative Medicine: Current Advances
Authors: Sousa Ana Catarina , Alvites Rui , Lopes Bruna , Sousa Patrícia , Moreira Alícia , Coelho André , Santos José Domingos , Atayde Luís , Alves Nuno , Maurício Ana Colette
Published: November 2024

The application of three-dimensional (3D) printing/bioprinting technologies and cell therapies has garnered significant attention due to their potential in the field of regen-erative medicine. This paper aims to provide a comprehensive overview of 3D print-ing/bioprinting technology and cell therapies, highlighting their results in diverse medical applications, while also discussing the capabilities and limitations of their com-bined use. The synergistic combination of 3D printing and cellular therapies has been recognised as a promising and innovative approach, and it is expected that these tech-nologies will progressively assume a crucial role in the treatment of various diseases and conditions in the foreseeable future. This review concludes with a forward-looking perspective on the future impact of these technologies, highlighting their potential to revolutionize regenerative medicine through enhanced tissue repair and organ re-placement strategies.
A UAV Mission Computer Operation Modes Optimization Focusing on Computational Energy Efficiency and System Responsiveness
Authors: Liubimov Oleksandr , Turkin Ihor , Volobuyeva Lina
Published: November 2024

The rising popularity of UAVs and other autonomous control systems, coupled with real-time operating systems, has increased the complexity of developing systems with the proper robustness, performance, and reactivity. Concurrently, the growing demand for more sophisticated computational tasks, proportionally bigger payloads, battery limitations, and smaller take-off mass necessitates higher energy efficiency for all avionics and mission computers. The purpose of this paper is to develop the technology for experimental studies of indicators of reactivity and energy consumption of the computing platform for unmanned aerial vehicles (UAVs). The paper provides an experimental assessment of the ’Boryviter’ 0.1 computing platform, which is implemented on the ATSAMV71 microprocessor and operates under the open-source FreeRTOS operating system. The results obtained are the basis for developing algorithms and energy-efficient design strategies for the mission computer to solve the optimization problem. The paper provides experimental results of measurements of the energy consumed by the microcontroller and estimates of the reduction in system energy consumption due to additional time costs for suspending and resuming the computer’s operation. The results show that the ’Boryviter’ 0.1 computing platform can be used as a UAV mission computer for typical flight control tasks that require real-time computing under the influence of external factors. As the further work direction, authors plan to carry out the investigation of the proposed energy saving algorithms in scope of the planned NASA’s F’Prime software flight framework. Such an investigation that should be done with the real flight computation load for the mission computer, will help to qualify the obtained energy saving methods and their implementation results.
Rationality of Neurological Clinical Trials: A Challenge that the FDA must Resolve
Authors: Niazi Sarfaraz K.
Published: November 2024

Antibodies approved by the FDA are failing to treat neurological disorders, and recently, it was reported that these trials may have violated patient’s rights and subjected them to high, likely lethal risk. The challenge with developing antibodies to treat neurological orders is their almost negligible bioavailability, requiring high dosing that can be toxic. The high potency of these drugs should also be viewed considering the placebo effects since all antibodies have shown severe side effects that are not prevented by the placebo responses. In this critical and urgent advice to the FDA, I am suggesting a guideline amendment to all clinical trials requiring proof of sufficient bioavailability at the site of action, where it is known. For antibodies to cross the blood-brain barrier, there are proven solutions such as conjugating with transferrin protein, making clinical trials in its absence more questionable and unethical.
Overview on Clinical Relevance of Antibodies Against Oxidized Low-Density Lipoprotein (oLAb) Within Three Decades by ELISA Technology
Authors: Wonisch Willibald , Tatzber Franz , Lindschinger Meinrad , Falk Andreas , Resch Ulrike , Mörkl Sabrina , Zarkovic Neven , Cvirn Gerhard
Published: November 2024

One of the most prominent actions of oxidative stress is the attack of free radicals on polyunsaturated fatty acids (PUFAs), initiating a chain reaction to modify these PUFAs and generate oxidized modifications on all biomolecules. In the last quarter of the 20th century, intensive research was carried out to identify antibodies against such modifications. In the mid-90s, the first enzyme-linked immunosorbent assay (ELISA) was introduced to the market, significantly accelerating research activities and knowledge gain. During this pioneering period, the main focus was on cardiovascular diseases, cancer, diabetes and other diseases associated with oxidative stress. Subsequently, a standard range of these antibodies against oxidized LDL (oLAb) was determined in the population. Further, the impact of exhaustive physical activity and diet on oLAb titers and the correlation between newborns and mothers after delivery, as well as concerning nutritional intake in newborns was evaluated. Subsequently, the harmful effects of smoking, and many other areas regarding oLAb titer were published, resulting in novel approaches for prognostic and therapeutic options, in particular through studies with antioxidants, which were able to influence oLAb significantly. This review presents an overview of the research activities obtained with this ELISA over the past three decades.
Effects of a Serratus Anterior Plane Block After Lung Wedge Re-Section: A Prospective, Randomized Controlled Trial
Authors: Lee Seok Jin , Sung Tae-Yun , Cho Choon-Kyu , Lee Gyuwon , Kwon Woojin
Published: November 2024

Background: Video-assisted thoracoscopic surgery (VATS) is associated with less postoperative pain than traditional open thoracotomy. However, trocar and chest tube placement may damage the intercostal nerves, causing significant discomfort. An ultrasound-guided serratus anterior plane block (SAPB) is a promising mode of pain management; this reduces the need for opioids and the associated side-effects. This study evaluated whether SAPB, compared to intravenous analgesia alone, reduces opioid consumption after thoracoscopic, lung wedge resection. Methods: In total, 22 patients undergoing VATS lung wedge resections were randomized into two groups (SAPB and control): both received intravenous patient-controlled analgesia (PCA) and one group received additional SAPB. The primary outcome was cumulative intravenous fentanyl consumption at 8 hours postoperatively. The visual analog scale (VAS) pain scores, and the incidence of postoperative complications were assessed over 48 h post-surgery. Results: Fentanyl consumption by 8 h post-surgery was significantly lower in the SAPB group than in the control group (183 ± 107 μg vs. 347 ± 202 μg, p = 0.035). Although VAS scores decreased with time in both groups, the differences were not statistically significant. The SAPB group required less opioids by 48 h. No significant between-group differences were observed in postoperative complications, including nausea and vomiting. Conclusions: SAPB effectively reduced opioid consumption after VATS lung wedge resection. SABP may serve as a valuable component of multimodal pain management.
Time in a Quantum Sensitive Extension of Special Relativity
Authors: Yurchenko Sergey B.
Published: November 2024

This paper proposes an extension of special relativity (SR) motivated by the properties of the mathematical continuum in nonstandard analysis of infinitesimals, with a direct impact on the fundamental aspects of quantum physics. The Planck length emerges spontaneously in Minkowski space as a halo around a lightlike point of the actual local present, induced by a hyperbolic metric. The halo generates an event horizon of the point, collapsing under observation/measurement. Unlike virtual black holes, the halo appears as a fundamental property of spacetime, regarded then as quantum foam that evaporates immediately by passing into the past. The extended SR (SRE) entails the following corollaries: (i) the relativity of extended simultaneity, (ii) Bell temporal non-separability, (iii) time vanishes at the cosmological horizon of the universe, (iv) the universe is closed from the inside. There is a complementarity in Bohr’s sense between classical SR and quantum-sensitive SRE by formally endowing the halo with the properties of a complex Hilbert space.
Introducing ActiveInference.jl: A Julia Library for Simulation and Parameter Estimation with Active Inference Models
Authors: Nehrer Samuel William , Ehrenreich Laursen Jonathan , Heins Conor , Friston Karl , Mathys Christoph , Thestrup Waade Peter
Published: November 2024

We introduce a new software package for the Julia programming language, the library ActiveInference.jl. To make active inference agents with Partially-Observable Markov Decision Process (POMDP) generative models available to the growing research community using Julia, we re-implemented the pymdp library for Python. ActiveInference.jl is compatible with cutting-edge Julia libraries designed for cognitive and behavioral modeling as it is used in computational psychiatry, cognitive science, and neuroscience. This means that POMDP active inference models can now easily be fit to empirically observed behavior, using sampling as well as variational methods. In this article, we show how ActiveInference.jl makes building POMDP active inference models straightforward, and how it enables researchers to use them for simulation as well as fitting them to data or to do model comparison.
Detecting Delirium in Older People: The Development of a Web-based Tool for Family Caregivers
Authors: Hou Jia , Wongpakaran Tinakon , Tamdee Decha , Rattakorn Phuanjai , TSOH Joshua , Wongpakaran Nahathai
Published: November 2024

Background and Objectives: Delirium is a common neuropsychiatric syndrome in older adults, often identified by caregivers. However, there are currently no accessible tools for family caregivers in Thailand to detect delirium. This study aimed to develop a web-based tool, ‘delirium-detect,’ to assist caregivers in identifying delirium in older individuals.
Methods: A research and development approach was employed, involving literature reviews, expert and key informant interviews, focus groups, content validity assessments, and pilot testing. The final tool features a 22-item symptom checklist that guides caregivers in assessing delirium, available on both PCs and mobile devices in Thai and English. It also provides daily home care guidance and emphasizes early detection. Expert reviews confirmed high validity (content validity index of 1.00). Results: All participants completed the questionnaires in a pilot test with 11 caregivers of older adults diagnosed with delirium, indicating criterion validity. The overall satisfaction was high, with 54.5% "liking" the tool and reporting ease of use. Participants spent an average of 9.09 minutes using the tool, with around 5 minutes for the questionnaire.
Conclusions: The ‘delirium-detect’ tool proved practical and user-friendly, highlighting its potential for early delirium detection in older adults. Further research is needed for broader implementation.
Stress Analysis in Conversion Hip Arthroplasty After Intertrochanteric Femoral Fracture Surgery: A Finite Element Method on the Impact of Stem Length on Distal Screw Hole Stress
Authors: Shimasaki Koshiro , Nishino Tomofumi , Yoshizawa Tomohiro , Watanabe Ryunosuke , Hirose Fumi , Yasunaga Shota , Mishima Hajime
Published: November 2024

Background/Objectives: Proximal femoral fractures are particularly common in older adults and cases requiring conversion to total hip arthroplasty may arise because of treatment failure or osteoarthritis. Fractures around the distal screw removal holes can be problematic. This study aimed to analyze the relationship between stem length and femoral stress distribution to determine the optimal stem length. Methods: A finite element analysis simulation was conducted using pre-existing femoral computed tomography data, an intramedullary nail, and three types of stems of varying lengths. Loads simulating normal walking and stair climbing were applied and the average and maximum equivalent stresses were measured on both the medial and lateral sides of the distal screw removal hole for each stem length. Statistical analysis was then performed to evaluate the stress distributions. Results: The average stress around the distal screw removal hole tended to decrease as stem length increased. The maximum stress was significantly lower with the 160-mm stem, which provides a 40-mm bridging length, compared to the 120-mm and 130-mm stems, where the stem tip aligned with or only slightly extended past the distal screw removal hole (bridging lengths of 0 mm and 10 mm, respectively). Conclusion: In conversion hip total arthroplasty following proximal femoral fractures, using a sufficiently long stem can help avoid stress concentration around the distal screw removal hole, thereby potentially reducing the risk of periprosthetic fractures.
Management Of Forecast Risk With Usage Of Monte Carlo Simulations For Solving Veridical Type Paradoxes
Authors: Pavlik Martin , Michalski Grzegorz
Published: November 2024

Managing forecast risk is key during the treasury management process. The entire treasury management process [8] is moving into the future and is therefore based on the prediction of future free cash flows discounted at the cost of capital. We used both numerical method and analytical method to solve veridical type paradoxes. We used Monte Carlo simulation as numerical method. Following analytical methods were used: conditional probability [10], Bayes' rule and Bayes' rule with multiple conditions. We successfully solved all the veridical type paradoxes and discovered why such a big discussion of Monty Hall problem appeared in 90s. We varied Monty Hall problem, using different doors count and prizes count.
Energy Demand Response in a Food Processing Plant: A Deep Reinforcement Learning Approach
Authors: Wohlgenannt Philipp , Hegenbart Sebastian , Eder Elias , Kolhe Mohan Lal , Kepplinger Peter
Published: November 2024

The food industry faces significant challenges in managing operational costs due to its high energy intensity and rising energy prices. Industrial food processing facilities, with substantial thermal capacities and large demands for cooling and heating, offer promising opportunities for demand response (DR) strategies. This study explores the application of deep reinforcement learning (RL) as an innovative, data-driven approach for DR in the food industry. By leveraging the adaptive, self-learning capabilities of RL, energy costs in the investigated plant are effectively decreased. The RL algorithm is compared with the well-established optimization method mixed integer linear programming (MILP), and both are benchmarked against a reference scenario without DR. The two optimization strategies demonstrate cost savings of 17.57% and 18.65% for RL and MILP, respectively. Although RL is slightly less efficient in cost reduction, it significantly outperforms in computational speed, being approximately 20 times faster. During operation, RL only needs 2 ms per optimization compared to 19 s per MILP, making it a promising optimization tool for edge computing. Moreover, while MILP's computation time increases considerably with the number of binary variables, RL efficiently learns dynamic system behavior and scales to more complex systems without significant performance degradation. These results highlight that deep RL, when applied to DR, offers substantial cost savings and computational efficiency, with broad applicability to energy management in various applications.
Sustainable Development Goals (SDGs) as a framework for Resident-Visitor Interaction at a Music Festival
Authors: Chiya Amos , Funck Carolin
Published: November 2024

This study uses action research at a rural community music festival, to explore the community-based exchanges between local community members and visiting musicians and how it aligns with Sustainable Development Goals (SDGs) 3, 4, and 11—focusing on good health and well-being, quality education, and sustainable cities and communities, respectively. Adapting the framework of social exchange theory, authoethnography, informal conversations, surveys, and interview with local community members and stakeholders were used in this study. The findings revealed exchanges aligned with the targets of the SDGs, and how reciprocal benefits of cultural interactions foster both individual well-being and collective community resilience, contributing to sustainable community revitalization. The study not only extends current academic discussions on cultural sustainability but also provides practical insights for policymakers and community planners aiming to leverage cultural activities for regional development.
Statistical Complexity Analysis of Sleep Stages
Authors: Duarte Cristina D. , Pacheco Marianela , Iaconis Francisco R. , Rosso Osvaldo A. , Gasaneo Gustavo , Delrieux Claudio A.
Published: November 2024

Studying sleep stages is crucial for understanding sleep architecture, which can help identify various health conditions, including insomnia, sleep apnea, and neurodegenerative diseases, and allowing for better diagnosis and treatment interventions In this paper we explore the effectiveness of generalized weighted permutation entropy (GWPE) in distinguishing between different sleep stages from EEG signals. We provide a comparison of the performance of various machine learning algorithms using features derived from both standard permutation entropy and GWPE, demonstrating that GWPE significantly improves classification accuracy, particularly in identifying the transition between N1 and REM sleep. The results highlight the potential of GWPE as a valuable tool for understanding sleep neurophysiology and improving the diagnosis of sleep disorders.
Deriving an Explicit Solution for Midsegment Triangles: Extending Pythagorean Principles in Spatial Geometry
Authors: Dos Santos Bernardes Marco Aurélio
Published: November 2024

In a foundational study, dos Santos Bernardes 2024 explored how connecting points on a triangle's midsegment to its vertices forms triangles that conform to the Pythagorean theorem in both two- and three-dimensional spaces, unveiling deeper geometric relationships and extending Pythagorean principles to spatial geometry with an implicit solution. Building on this work, I present the derivation of an explicit solution, further elucidating these geometric relationships and enhancing our understanding of their spatial applications.
The Influence of Lateral Spacing of TiO2 Nanotube Coated Surfaces on the Early In Vivo Osseointegration
Authors: Negrescu Andreea Mariana , Ionascu Iuliana , Necula Madalina Georgiana , Tudor Niculae , Kamaleev Maksim , Zarnescu Otilia , Mazare Anca , Schmuki Patrik , Cimpean Anisoara
Published: November 2024

Due to the bio-inert nature of titanium (Ti) and subsequent accompanying chronic inflammatory response, the implant’s stability and function can be significantly affected, leading in time to a poor osseointegration process. To overcome this challenge and improve the overall performance of Ti implants, various surface modifications have been employed, amongst them the deposition of titanium oxide (TiO2) nanotubes (TNTs) onto the native surface through the anodic oxidation method. While numerous in vitro and in vivo studies have already reported the importance of nanotube diameter on cell behaviour and osteogenesis, information regarding the effects of nanotube lateral spacing on the in vivo osseointegration process is insufficient and hard to find. Considering this, in the present study two types of TNTs with different lateral spacing, e.g. 25 nm (TNTs) and 92 nm (spTNTs) were fabricated and comparatively investigated in terms of their effect on the early peri-implant new bone formation. The microscopic examination at 1-month post-implantation revealed that both nanotubular surfaces, particularly spTNTs, were capable of inducing new bone formation without a significant bone destruction. Overall, our results indicate that the lateral spacing of the TNT-coated Ti surfaces can influence the in vivo outcome, thus representing a significant factor in implant design.
Banking Credit and Innovation Technology: a Global Perspective
Authors: Costantiello Alberto , Arnone Massimo , Leogrande Angelo
Published: November 2024

The article reviews the linkage of banking credit with technological innovation at global level underlining that access to finance is important for and innovation. The domestic credit percentage involving the private sector to GDP allows projects of high risk but with a very high reward, projects that are key in increasing productivity and global competitiveness significantly. This paper explores that dynamic in infrastructure, creative industries, and greening technologies. Indeed, findings from such studies do show positive correlations, such as between credit and infrastructure development or creative exports, suggesting the capability of systems of finance to transform. These findings indicate the positive relationships that exist in some contexts, such as reduced R&D investment. Taking into account the ecological bottom line, this research underlines ecosystem-based strategies of banking, green credit, and poised financial regulations for sustainable development. Synthesizing into this paper provides actionable insight into how policy makers, financial institutions, and researchers can tap into the synergy between the financial system and innovation.