bluuebunny/crossref_metadata_2025 huggingface dataset:
Risks and opportunities of the socio-digital environment in the context of education: philosophical and sociological research
Authors: Краузе А.А. , Шишигин А.В.
Published: July 2024

Данная статья носит характер междисциплинарного исследования. В ней рассматривается феномен цифровизации с точки зрения философского и социологического подходов в контексте сложившихся условий в современном российском обществе. Авторы выделяют основные аспекты, раскрывающие природу и специфику «цифровой среды» в сфере образования, характеризуют цифровую среду как институт и рассматривают как предмет социальной практики. В исследовании с точки зрения философско-социологического анализа раскрываются субъектные трансформации и динамика ценностных ориентаций личности в условиях развития цифрового и сетевого общества. Дается анализ современного дискурса образования в контексте включенности субъектов образовательного процесса в цифровые реалии. Свои выводы авторы подкрепляют данными социологического опроса учителей, проведенного в крупных городах семи регионов РФ для определения интериоризации цифрового дискурса субъектами системы современного образования. Основываясь на результатах исследования, авторы приходят к выводу, что педагогическое сообщество взвешенно и объективно оценивает риски и возможности цифровизации современного общества, видит необходимость стратегического, методиче ского и ценностного обоснования ее осуществления.

This article is in the nature of an interdisciplinary study. It examines the phenomenon of digitalization from the point of view of philosophical and sociological approaches in the context of the prevailing conditions in modern Russian society. The authors identify the main aspects that reveal the nature and specifics of the "digital environment" in the field of education, characterize the digital environment as an institution and consider it as a subject of social practice. In the study, from the point of view of philosophical and sociological analysis, the subjective transformations and dynamics of value orientations of the individual in the conditions of development of digital and networked society are revealed. The analysis of the modern discourse of education in the context of the inclusion of the subjects of the educational process in digital realities is given. The authors support their conclusions with the data of a sociological survey of teachers conducted in large cities of seven regions of the Russian Federation to determine the internalization of digital discourse by the subjects of the modern education system. Based on the results of the study, the authors conclude that the pedagogical community carefully and objectively assesses the risks and opportunities of digitalization of modern society, sees the need for strategic, methodological and value justification of its implementation.
Американская эпопея епископа Нестора (Засса)
Authors: Pechatnov V.V. , Pechatnov V.O.
Published: July 2024

The article is devoted to the life and work of Bishop Nestor (Zassa) during his leadership of the Aleutian and Alaska diocese (1878–1882). It is written on the basis of documents from the archive of the Russian Orthodox Church in Alaska and represents the first attempt in Russian and foreign historiography to analyze the role and place of His Grace Nestor in the formation and development of the Russian spiritual Mission in the USA.. It also gives a portrait of this unusual and tragic figure; it shows how his fragile and exalted nature could not withstand a collision with the reality of church administration in the difficult conditions of internal intrigues and alien environment. Through the prism of the personality of the pastor, the picture of the daily life of the Russian Orthodox clergy in America in the 1870s–1880s is given. The article also gives a concrete idea of how the mechanism of diocesan administration and interaction of church and secular authorities worked in the Russian Empire.

Статья посвящена жизни и деятельности епископа Нестора (Засса) в период руководства им Алеутской и Аляскинской епархией (1878–1882 гг.). Она написана на основе документов архива Русской православной церкви на Аляске и представляет собой первую в российской и зарубежной историографии попытку дать анализ роли и места преосвященного Нестора в становлении и развитии Русской духовной миссии в США. В ней также дается портрет этой необычной и трагической фигуры; показывается, как его хрупкая и возвышенная натура не выдержала столкновения с реальностью церковного управления в тяжелых условиях внутренних интриг и чужеродного окружения. Через призму личности пастыря дается картина повседневной жизни российского православного духовенства в Америке 1870–1880-х гг. Статья также дает конкретное представление о том, как в Российской империи работал механизм епархиального управления и взаимодействия церковных и светских властей.
Из истории трансформации имперской стратегии и политики оформления фрактального «педагогического пространства» Санкт-Петербурга XVIII в.
Authors: Onishchenko E.V. , Malyazina M.A.
Published: July 2024

The tasks of modernization of the system of vocational education in the Russian Federation at the present turn of the historical spiral of development raise the question of the need for a systematic assessment of the origins and leading aspects of the formation and design of the system of higher vocational training in Russia, which took place in the XVIII century. The article presents for the first time a comparative analysis of the organization and reform of Russian education in this historical period on the example of the design of individual "pedagogical corners" of the urbanized environment of St. Petersburg as a special Westernized metropolis. The authors, based on a binary system of original criteria, gave a fractal assessment of the educational space of the "northern capital", stated the innovative aspects of the characteristics of the historical dynamics of the axiological attitudes of the implementation of the imperial educational strategy during the XVIII century – from the "utilitarian-practical" (reign of Peter I) through the "aesthetic" (reign of Elizabeth Petrovna) to the "ethical" (period the reign of Catherine II). The materials of the article can be applied in pedagogical practice in the development of the necessary specialized trajectory and algorithm of historical and pedagogical training in the conditions of modernization of the vocational training system in modern Russia.

Задачи модернизации системы профессионального образования в Российской Федерации на современном витке исторической спирали развития ставят вопрос о необходимости системной оценки истоков и ведущих аспектов становления и оформления системы высшей профессиональной подготовки в России, которое происходило в XVIII веке. В статье впервые представлен сравнительный анализ организации и реформирования российского образования в данный исторический период на примере оформления отдельных «педагогических уголков» урбанизированной среды Санкт-Петербурга как особого вестернизированного мегаполиса. Авторами на основе бинарной системы оригинальных критериев дана фрактальная оценка образовательного пространства «северной столицы», заявлены новационные аспекты характеристики исторической динамики аксиологических установок реализации имперской образовательной стратегии в течение XVIII века – от «утилитарно-практической» (правление Петра I) через «эстетическую» (правление Елизаветы Петровны) к «этической» (период правления Екатерины II). Материалы статьи могут быть применены в педагогической практике при выработке необходимой специализированной траектории и алгоритма историко-педагогической подготовки в условиях модернизации системы профессионального обучения в современной России.
Студенческая научно-практическая конференция «Язык, личность, деятельность: взгляд молодых исследователей»: актуальная тематика, научный поиск, дискуссия
Authors: Tatarinova M.N. , Beresneva V.A.
Published: July 2024

An important area of work of Russian universities is the organization and holding of student scientific and practical conferences. They contribute to the improvement of students' research activities, the growth of its theoretical and practical significance. Teachers of the Department of Foreign Languages and Methods of Teaching Foreign Languages at the Faculty of Linguistics of Vyatka State University have accumulated useful experience in preparing and conducting student scientific and practical conferences of various levels. The purpose of the article is to characterize the process of organizing and holding the faculty student scientific and practical conference "Language, personality, activity: the view of young researchers". The conference was part of the implementation of the traditional annual cathedral project of the same name. Reports on relevant methodological topics were made at the plenary session. They are devoted to the problems of realizing the educational potential of the subject "Foreign language", the comprehensive development of students by means of this subject. The interim results of the cathedral project were summed up, the most active and successful participants of the faculty stage of the design and educational intensive of the Institute of Humanities and Social Sciences were awarded. The continuation of the conference was the work of its sections, where students of the final courses of bachelor's and master's degrees demonstrated the results of research work on the methodology of teaching foreign languages. The reports of undergraduates raised issues of the use of emotionally colored techniques, collaborative technologies, modular organization of foreign language teaching, etc. The reports of graduates of the bachelor's degree touched upon the problems of formation of foreign language lexical skills, the use of role-playing, "edutainment" technologies and the development of critical thinking in teaching various types of foreign language speech activity.
An algorithm for redistributing virtualized computing and communication resources of a data center based on ACS metaheuristics
Authors: Бумажкина Н.Ю.
Published: July 2024

Перераспределение виртуализированных вычислительных и коммуникационных ресурсов в центрах обработки данных представляет собой значительную проблему в контексте облачных технологий, осложняя обеспечение стабильного функционирования сервисов. Эти сервисы должны соответствовать критериям качества обслуживания, оценки производительности и условиям контрактов на обслуживание, которые предъявляют поставщики облачных услуг. Главная цель перераспределения виртуализированных вычислительных и коммуникационных ресурсов – оптимальное размещение подмножества активных виртуальных машин на минимальном количестве физических машин с учетом их многомерных потребностей в вычислительных и коммуникационных ресурсах. Что значительно улучшит эффективность работы виртуализированного центра обработки данных. Проблема перераспределения вычислительных и коммуникационных ресурсов центра обработки данных попадает под класс проблем, определяемых как «NP-трудные» проблемы, так как предполагает обширное пространство решений. Поэтому необходимо больше времени для нахождения оптимального варианта. В предыдущих исследованиях ряда таких проблем было доказано, что метаэвристические стратегии позволяют находить приемлемые решения за пригодное время. В статье предлагается использовать модифицированный вариант метаэвристического алгоритма муравьиной колонии для решения задачи перераспределения вычислительных и коммуникационных ресурсов между виртуальными машинами центра обработки данных, рассматриваемой в рамках задачи многомерной векторной упаковки.

The redistribution of virtualized computing and communication resources in data centers is a significant problem in the context of cloud technologies, making it difficult to ensure the stable functioning of services. These services must meet the criteria for quality of service, performance evaluation, and terms of service contracts imposed by cloud service providers. The main goal of the redistribution of virtualized computing and communication resources is the optimal placement of a subset of active virtual machines on a minimum number of physical machines, taking into account their multidimensional needs for computing and communication resources. Which will significantly improve the efficiency of a virtualized data center. The problem of redistributing computing and communication resources of a data processing center falls under the class of problems defined as "NP-hard" problems, since it involves a vast space of solutions. Therefore, more time is needed to find the optimal option. In previous studies of a number of such problems, it has been proven that metaheuristic strategies make it possible to find acceptable solutions in a suitable time. The article proposes to use a modified version of the ant colony metaheuristic algorithm to solve the problem of redistributing computing and communication resources between virtual machines of a data processing center, considered within the framework of the multidimensional vector packaging problem.
Copper-Catalyzed Enantioselective [4π + 2σ] Cycloaddition of Bicyclobutanes with Nitrones
Authors: Zhang Xuan-Ge , Zhou Zi-Yang , Li Jia-Xin , Chen Jun-Jia , Zhou Qi-Lin
Published: July 2024

The selective construction of bridged bicyclic scaffolds has garnered increasing attention due to their extensive use as saturated bio-isosteres of arene in pharmaceutical industry. However, in sharp contrast to their racemic counterparts, assembling chiral bridged bicyclic structures in an enantioselective and regioselective manner remains challenging. Herein, we describe our protocol for constructing chiral 2-oxa-3- azabicyclo[3.1.1]heptanes (BCHeps) by enantioselective [4π + 2σ] cycloadditions of bicyclo[1.1.0]butanes (BCBs) and nitrones taking advantage of a chiral copper(II) complex as Lewis acid catalyst. This method features mild condition, good functional group tolerance, high yield (up to 99%) and excellent enantioselectivity (up to 99% ee). Density functional theory (DFT) calculation elucidates the origin of the reaction's enantioselectivity and the mechanism of BCB activation by Cu(II) complex.
Carbon footprint comparison of liquid organic hydrogen carriers cycled thermochemically and electrochemically
Authors: Chilunda Moses D. , Talipov Sarvarjon A. , Biddinger Elizabeth J.
Published: July 2024

Hydrogen (H2) has been proposed as a way to store energy for long durations with minimal carbon footprint. The challenges of using H2 to store energy are that it has very low volumetric density and diffuses rapidly through container walls. Liquid organic hydrogen carriers (LOHCs) have been proposed as a method of storing hydrogen in the molecular backbone of stable organic chemicals, addressing many of the concerns of molecular hydrogen. The majority of LOHC systems proposed have utilized thermochemical cycling for the hydrogenation (to store hydrogen) and dehydrogenation (to release hydrogen). Thermochemical cycling requires heating of the reactors, which results in an increased carbon footprint, and is not easily amenable to dynamic operating with the variable renewable electricity grid. Electrochemical LOHC cycling has been proposed as an alternative to thermochemical cycling because it can pair directly with the variable renewable grid and operate more dynamically. To understand the viability of the thermochemical and electrochemical processes, a comparative carbon footprint analysis is necessary. The primary finding from this analysis was that the electrochemical LOHC cycling process has the lowest carbon footprint only when highly concentrated LOHCs were used as the feed. The carbon footprint in electrochemical cycling of diluted LOHC was primarily contributed to by the LOHC distillation separation process. A sensitivity analysis showed the carbon footprint LOHC concentration dependence during the electrochemical cycling process. Moreover, the electrolyte composition significantly affects the carbon footprint during electrochemical LOHC cycling. Decisions regarding use of thermochemical versus electrochemical cycling need to include separation system boundaries, not just the reactors themselves.
Controlling carbodiimide-driven reaction networks through the reversible formation of pyridine adducts
Authors: Salvia William S. , Mantel Georgia , Saha Nirob K. , Rajawasam Chamoni W. H. , Konkolewicz Dominik , Hartley C. Scott
Published: July 2024

Carbodiimides and pyridines form reversible adducts that slowly deliver carbodiimide “fuels” to out-of-equilibrium reaction networks, slowing activation kinetics and elongating transient state lifetimes. More-nucleophilic pyridines give more adduct under typical conditions. This approach can be used to extend the lifetimes of transient polymer hydrogels.
SUSTAINABLE FINANCE – A WAY TO IMPROVE SOCIAL AND ECONOMIC SUSTAINABILITY. THE ROMANIAN EXPERIENCE
Authors: TRANDAFIR Adina
Published: July 2024

Sustainable finance is a concept that refers not only to environmental problems, but also to social objectives such as those social goals included in the 2030 Agenda for Sustainable Development. Summarizing, it refers to societal impact. In literature, this term - societal impact – is used with the meaning of social, environmental, medical or cultural impact [Rizzi F. et al., 2018; EVPA Report, 2017].
The current challenges regarding the future development of the social finance market refer to the opacity of its conceptual bases. For this reason, this article aims, among other things, to clarify the basic concepts and instruments of social finance and their continuously developing market, analyzing the literature in the field. Thus, first of all, we analyze the structuration processes that take place in social finance and the institutional actors involved. Also, a conceptual delimitation of social investments and the way in which they are selected is necessary.
Last but not least, reviewing the literature, this article addresses to the analysis of the financial instruments (FI) used on the social finance market and their impact, also addressing the issue of the usefulness of tailored finance of a social purpose organization.
Regarding the experience on the social finance market in Romania, this article aims a static and dynamic analysis of the financial instruments used, as well as of the entities in the Romanian social economy, proposing solutions to improve public policies in terms of sustainable finance and social economy from our country.
Strategic Total Rewards accross Generations during Pandemic
Authors: Mabaso Calvin , Barkhuizen Nicolene , Ankiah Thylanu
Published: July 2024

This study explored the influence of the Fourth Industrial Revolution (4IR) on total rewards within the pharmaceutical industry, specifically focusing on Middle and Senior Managers as the sample. The study explored the total rewards that the sample found valuable based on their gender and generational cohort, ie, Baby Boomers, Gen X and Millennials.  A qualitative research approach utilised for the current study uses phenomenology to explore employees' lived experiences in the pharmaceutical industry.  Data was gathered by conducting semi-structured interviews, with open-ended questions, to gain insight into specific topics, such as 4IR, COVID-19, total reward preferences, age and gender. The research findings indicated that 4IR and Covid-19 influenced pharmaceutical industry employees’ total rewards preferences. The findings also indicated that total rewards preferences are dependent on an employee's age, gender and life roles. An interesting finding was that regardless of age and gender, all employees valued the total reward of well-being above all others, but this reward was the most difficult to attain from their employer. The findings from the study may enable companies to become employers of choice.
Baú de Anuências e Aceites. Projetos do LADI-UnB que foram aprovados e viabilizados I
Authors: Mota Marcus
Published: July 2024

Neste artigo são disponibilizados projetos do Laboratório de Dramaturgia da Universidade que foram propostos para vários órgãos de financiamento de pesquisa e que foram aprovados. Tais projetos foram o fundamento conceptual para diversos processos criativos, artigos e livros.
Espaço Cênico-Musical: vida em movimento – ação
Authors: Matos Elvis de Azevedo
Published: July 2024

O presente artigo tem intuito de fazer um mapeamento panorâmico das metodologias, formas de ensaio e de montagem dos espetáculos do Coral da Universidade Federal do Ceará. Pretende-se discutir com mais circunspecção a concepção de espetáculo mais atualmente orquestrada pelos regentes do coro, na esteira do trabalho da estudiosa Izaíra Silvino. Nessa perspectiva, o espetáculo, ainda que se utilize de procedimentos e aspectos teatrais, se encaminha para uma forma de performance que põe em relevo o coro como personagem coletivo e diretivo nas ações cênicas, enfatizando o caráter plurissemiótico das várias linguagens utilizadas em cena.
A performance musical na pintura dos vasos áticos e ápulos (séc. VIIV a.C.): os instrumentos de corda
Authors: Cerqueira Fábio Vergara
Published: July 2024

O presente artigo tem o propósito de analisar a performance dos instrumentos de corda na Antiguidade grega, focando os séculos VI a IV a.C. e os espaços da Grécia egeia, particularizado em Atenas, e da Grécia ocidental, circunstanciado na Itália Meridional, em Tarento e na Apúlia, a hinterlândia indígena itálica. Estudo especificamente a representação iconográfica das técnicas do krouein (tocar as cordas com o plektron) e do psallein (tocar com os dedos), interpretando aspectos culturais relacionados. Observo também a emergência no Sul da Itália de um gosto pela música instrumental, como um efeito local da Nova Música.
Singing Homer’s Spell. The Disyllabic Contonation and the Proposition Made by East Roman Manuscripts
Authors: David A. P.
Published: July 2024

Neste ensaio, propõe-se a reconstituição do perfil melódico do verso homérico, de forma a se possibilitar a compreensão e reperformance de textos como Ilíada e Odisseia.
Dossiê entre mídias: Dramaturgia e Tradução. A narração oral de Guimarães Rosa: do papel para a voz
Authors: Almeida Maria Elisa Pereira de
Published: July 2024

Para meschonnic (1989), a literatura é, por excelência, morada da oralidade, fluxo iluminador de sentido. Em zumthor (2014), vemos que, mesmo em leitura silen- ciosa, o texto literário é performático, provocando reações diversas em nosso corpo. O grupo miguilim (cordisburgo/mg) há 25 anos forma jovens para a arte da narração oral de textos de guimarães rosa. As narradoras diretoras do grupo atuam também como dramaturgas, produzindo as versões dos textos rosianos que são levados à cena da narração oral por meio do procedimento dramatúrgi- co que denominaram recorte. Ainda que o recorte implique em uma interferên- cia menor no texto original, ele não deixa de ser fruto de escolha pessoal, como acontece em qualquer outra dramaturgia.
Problematika logistiky pri skladovaní tvárniacich nástrojov a otázka opotrebovania činných dielov
Authors: Melo Borislav ,   University of Žilina
Published: July 2024

The article deals with the specific issue of the logistics of forming tools within the company. The submitted contribution in a brief overview points to possible situations that may arise in the production process when applying forming tools. It is also pointed out the possibilities of solving the situations that arise in the production preparation stage. An addition is also pointing out the issue of wear and tear of active parts of clippers and their renovation.
Vplyv teploty na Barkhausenov šum v Co a Gd
Authors: Neslušan Miroslav ,   University of Žilina, Čížek Jakub , Mičietová Anna , Čilliková Mária
Published: July 2024

The present paper deals with Barkhausen noise emission in Gd. Barkhausen noise emission was investigated in the temperature range mainly below the Gd Curie temperature when the spontaneous magnetization in Gd occurs. Barkhausen noise from the heavy rare-earth Gd is compared with Barkhausen noise emission from the transition metal Co measured at the same magnetizing and other conditions. This study demonstrates that Barkhausen noise emitted from Gd is much weaker than that originating from Co. This is a consequence of different spin exchange interaction among the neighbouring atoms, domain wall thickness as a well as domain wall energies. Moreover, Barkhausen noise is temperature sensitive especially for Gd sample as a result of the altering magneto-crystalline anisotropy.
Kovokeramické trecie materiály využívané v práškovej metalurgi
Authors: Kantoríková Elena ,   University of Žilina
Published: July 2024

Metal-ceramic materials are produced from a mixture of metal and ceramic powders. These are primarily sintered carbides for cutting tools and friction materials for brake linings. Their use is important in cases where it is not possible to use normal friction materials. Important is a high coefficient of friction even at high temperature, good thermal conductivity, strength and resistance to abrasion.
Features of “Sculpture” and “Painting” in Buddhist Statue Art
Authors: Guan Guifa
Published: July 2024

The solemn radiance of the Buddha, coupled with delicate brushwork, vibrant colors and exquisite craftsmanship, captivates and dominates the art of painted Buddhist statues. This art form, characterized by a unique style of representation, integrates the elements of sculpture, painting, engraving and drawing, enhancing the charm and spirituality of Buddhist statue art. Artists leverage their imagination and masterful skills, incorporating the essence of Tibetan Buddhism to depict the spiritual beliefs of mythical worlds vividly.
Exploration of Ideological and Political Education in the Comprehensive Japanese Course Based on the BOPPPS Model
Authors: Chen Boqiao
Published: July 2024

Course ideological and political education is not a rigid combination of curriculum and ideological and political elements, but a systematic project that requires continuous restructuring, design, and construction of course content. This article takes the fourth lesson of the Comprehensive Japanese 2 course as an example of designing ideological and political education based on the BOPPPS model. The ideological and political elements are integrated into each aspect of the teaching silently, in order to enable students to naturally accept the guidance of socialist core values and achieve the goal of cultivating morality and nurturing people.
A Study on the Difficulties and Countermeasures of Bilingual Chinese Language Learning for Shui Elementary School Students
Authors: Wei Tingna , Xiang Rong , Mao Yuxin , Liu Ying , Li Qingfei
Published: July 2024

This study aims to explore the difficulties and reasons faced by Shui ethnic elementary school students in bilingual Chinese language learning. Using literature review and case analysis methods, the study analyzes the manifestations and influencing factors of learning difficulties and proposes corresponding solutions and countermeasures, such as proposing learning strategies, optimizing teaching modes, family support, and school management strategies, to provide better support and assistance for Shui ethnic elementary school students in Chinese language learning. The study of the difficulties and countermeasures in bilingual Chinese language learning for Shui ethnic primary school students can promote educational equity, strengthen multicultural education, promote the development of education in ethnic minority areas, and also help improve the quality of bilingual Chinese language learning for Shui ethnic primary school students, enhance teaching effectiveness, which has essential practical and educational significance.
Characterization of blaNDM Gene in Multidrug-Resistant Pathogens
Authors: Zaman Ayesha , Sultan Hafiz Muhammad , Malik Noor Ul Ain , Waseem Raazia , Farooq Jawaria
Published: July 2024

Antibiotics have been a cornerstone of treatment approaches as they protect against bacteria; however, they are often used without checks and balances. Over time, these antibiotics have become less effective due to bacterial resistance mechanisms. Through natural selection and random mutation, bacterial pathogens have developed resistance against several classes of antibiotics. One such resistance is beta-lactam resistance, caused by gene variants including the NDM gene. To date, comprehensive studies on this gene and its variants are limited in Pakistan. In our present study, multiple antibiotics were used to determine the susceptibility of bacterial samples, including Acinetobacter, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli. 82% of the samples were bla-NDM gene positive, as determined through molecular characterization using multiplex PCR. Further studies should be conducted on a larger sample scale to obtain more impactful results regarding antibiotic resistance in various bacteria.
Stem Cells and Exosomes-associated Therapeutic Applications
Authors: Ahmed Usama , Abubakar Muhammad , Ayyoub Rooma , Rehman Baqaur
Published: July 2024

Exosomes are extracellular vesicles with sizes from 30 to 150 nm in diameter and modulate the transport of multiple intracellular biological molecules including proteins, nucleic acids, lipids, and metabolites. They regulate a large number of cells and are involved in different pathological and physiological activities including carcinogenesis, viral infection, cell-cell communication and immune responses as well. Stem cell-derived exosomes carry many benefits over simple stem cells in the form of easy access, freedom from tumourigenic capabilities, non-infusion toxicity, effortless preservation, and immunogenicity. Exosomes have almost the same properties and perform functions effectively in the same way as their parental cells do like adult stem cells and embryonic stem cells. Due to their pluripotent or multipotent abilities, stem cells (SCs) transform into several types of cells. In addition to other secretions, SC also give exosomes, which in turn shows therapeutic significance for many disorders, including cancer, diabetes mellitus, skin allergies and regenerative medicine. Exosomes originating from mesenchymal stem cells (MSCs) have miRNAs, lipids, and proteins that trigger diabetes and cancer situations in humans. Exosomes from SCs (sc-exos) are preferred to SC as there are fewer side effects and other challenges, including effectiveness, drug delivery, lower immunogenicity and tumourigenicity. In the current review, we summarize the data from the last 5 years’ articles about exosomes and stem cell-derived microvesicles for the therapeutic potential of various diseases such as cancer, Alzheimer’s disease, diabetes, and Parkinson’s disease with clinical challenges and future aspects.
Research Progress of Assessment Tools for Peripheral Venous Access Difficulties in Children
Authors: Zhang Ruifen , Xiao Litao , Dong Jing
Published: July 2024

Objective: To review the research progress of peripheral venous access difficulty assessment tools in children and to provide a reference for clinical nurses to select and develop appropriate assessment tools. Methods: Search the literature at home and abroad and summarize and analyze the existing evaluation tools. Results: There is no unified assessment tool about difficult venous access in children at home and abroad. The existing tools include the difficult venous access assessment scale and peripheral venous grading assessment tool. Conclusion: The current assessment tools for venous access difficulties in children have their own limitations, and it is necessary to develop further the assessment tools suitable for the cultural background of children’s venous access difficulties. This paper summarized the current progress of research on peripheral venous access difficulty assessment tools. It also analyzed and summarized the shortcomings of existing tools to provide a reference for clinical staff to choose appropriate assessment tools.
Effect of Continuous Double-Lumen Irrigation Drainage at Constant Temperature on the Control of Abdominal Infection After Surgery
Authors: Lin Junlu
Published: July 2024

Objective: To investigate the effect of continuous double-lumen irrigation drainage at constant temperature on the control of abdominal infection after surgery, providing a reference for clinical treatment. Methods: From December 2022 to August 2023, 100 patients with abdominal infections after surgery were selected from Wendeng People’s Hospital in Weihai. They were randomly divided into a control group (50 cases, using conventional single-hole rubber irrigation drainage) and an observation group (50 cases, using continuous double-lumen irrigation drainage at constant temperature). The inflammatory and immune indicators of the two groups were compared after different interventions, and the specific conditions of abdominal infection were statistically analyzed. Results: There was no significant difference in inflammatory indicators between the two groups before intervention (P > 0.05). After the intervention, the inflammatory indicators of the observation group were significantly lower (P < 0.05). There was no significant difference in immune function indicators between the two groups before intervention (P > 0.05). After intervention, the immune function indicators of the observation group showed significant improvement (P < 0.05). The control of abdominal infection in the observation group was better than in the control group (P < 0.05). Conclusion: Continuous double-lumen irrigation drainage at constant temperature has a better effect on controlling abdominal infection after surgery, improving the infection condition, and enhancing the immune function of patients.
Clinical Observation of Regorafenib Combined with Immune Checkpoint Inhibitor for Advanced Colorectal Cancer of pMMR/MSS Type
Authors: Shi Zhe , Zhou Liyuan , Zhao Guodong
Published: July 2024

Objective: To observe the clinical efficacy and safety of regorafenib combined with immune checkpoint inhibitors in the treatment of patients with advanced colorectal cancer of pMMR/MSS type. Methods: 42 patients with advanced colorectal cancer of pMMR/MSS type admitted to the Department of Oncology of our hospital from January 2022 to September 2023 were randomly divided into the observation group and the control group, 21 cases each. The observation group was treated with the addition of regorafenib combined with immune checkpoint inhibitors, while the control group was given regorafenib monotherapy, and the efficacy, adverse effects, and survival of patients in the two groups were observed. Results: the total remission rate of the control group was 23.81%, and the total remission rate of the observation group was 57.14%, and the difference between the two groups was statistically significant (P < 0.05); there were 14 cases of adverse reactions in the two groups, with an incidence rate of 33.33% (14/42); and the overall survival rate of the observation and control groups was 71.43% and 47.62%, respectively. The survival rate of the observation group was higher than that of the control group, but the difference was not statistically significant (P > 0.05). Conclusion: Regorafenib combined with anti-PD-1 monoclonal antibody can significantly improve the efficacy and prognosis of advanced colorectal cancer without increasing adverse effects.
Analysis of the Effect and Adverse Reaction of Cisplatin Metronomic Chemotherapy Combined with Radiotherapy in the Treatment of Stage II–IV Nasopharyngeal Carcinoma
Authors: Yasheng Maimaiti Yiming , Rouzi Mireguli , Yasen Shokaya , Li Ainivarjiang Abdu Rousu
Published: July 2024

Objective: To analyze the effect and adverse reaction of cisplatin metronomic chemotherapy combined with radiotherapy in the treatment of stage II–IV nasopharyngeal carcinoma. Methods: Fifty nasopharyngeal cancer patients (in stage II–IV) admitted to our hospital from January 2022 to December 2023 were selected and randomly divided into a control group and an observation group of 25 cases each. The control group was treated with cisplatin conventional chemotherapy combined with radiotherapy and the observation group was treated with cisplatin metronomic chemotherapy combined with radiotherapy. Both groups were compared in terms of recent efficacy, adverse effects, natural killer (NK) cell activity, T-cell subpopulation changes, and treatment adherence. Results: The clinical remission rate of the two groups were not significant (P > 0.05), but the incidence of adverse reactions in the observation group was lower than that in the control group, and the levels of NK cell activity, CD3, CD4, and CD4/CD8 cells in the observation group were higher than that in the control group after treatment (P < 0.05). The treatment compliance in the observation group was higher than that in the control group (P < 0.05). Conclusion: In the treatment of stage II–IV nasopharyngeal carcinoma, adopting cisplatin metronomic chemotherapy combined with radiotherapy therapy achieved better therapeutic efficacy, reduced adverse reactions, increased NK cell activity, regulated T-cell subsets, and has an overall high application value.
Rule Based System to Support Decisions on Determining Employee Status (Lecturers) for Scholarship Student Graduates
Authors: Sipayung Hotma Sadariahta , Andriyani Widyastuti , Purnomosidi Dwi Putranto Bambang , Kriestanto Danny
Published: July 2024

Salah satu permasalahan yang terjadi di Universitas Teknologi Digital Indonesia (UTDI) adalah proses seleksi yayasan Dosen Tetap yang disebut-sebut baru untuk diterapkan kepada mahasiswa penerima calon beasiswa S2 di Magister Teknologi Informasi (MTI). UTDI Yogyakarta. Kriteria yang digunakan dalam aturan tersebut adalah Indeks Prestasi (IP) Semester 1, IP Semester 2, IP Semester 3, Indeks Prestasi Kumulatif (IPK), Makalah (karya ilmiah), Kerjasama, Disiplin, Komunikasi, Pra Tesis, Tesis, Nilai C. , dan Durasi Studi yang diperoleh dari MTI UTDI, selanjutnya akan menggunakan Algoritma C4.5 untuk menghasilkan pohon keputusan yang akan dipelajari aturan dalam sistem. Penelitian ini menggunakan kaidah yang diperoleh dari MTI UTDI oleh Ketua Program Studi (Kaprodi) yaitu 41 data latih dan 8 data uji. Menggunakan forward chaining sebagai metode dalam sistem pakar yang mencari solusi melalui permasalahan, kemudian menggunakan Algoritma C4.5 yang merupakan algoritma yang digunakan untuk membentuk pohon keputusan. Aturan yang terbentuk kemudian digunakan untuk memprediksi kelayakan lulusan beasiswa Magister menjadi Dosen Tetap, Dosen Kontrak, atau tidak memenuhi persyaratan. Hasil prediksi tersebut kemudian dievaluasi menggunakan Confusion Matrix dan memperoleh nilai akurasi sebesar 75%, Precision sebesar 77,78%, dan Recall sebesar 77,78%. Sehingga Algoritma C4.5 dengan menggunakan aplikasi RapidMiner cukup layak digunakan untuk mendukung pengambilan keputusan dalam pemilihan mahasiswa penerima beasiswa Magister yang akan diangkat menjadi Dosen Tetap, Dosen Kontrak maupun yang tidak memenuhi syarat sebagai Dosen di UTDI. Fakultas Teknologi Informasi
Prolegómenos a una ontología del texto traducido
Authors: Martínez Villarreal Gabriel
Published: July 2024

Como cimentación teórica para una propuesta interdisciplinaria de filosofía de la traducción, se presentan unos prolegómenos a una ontología del texto traducido. A partir de las categorías de “ser ahí” y “ser así” en Nicolai Hartmann, de la noción de relación en cuanto relación como concepto metafísico absoluto en José Luis Cisneros Arellano y de la teoría del ensamblaje en Manuel DeLanda, se ofrece una respuesta a la pregunta ontológica fundamental por el ser de la traducción en cuanto que ente textual. Tras argumentar a favor de la ontología como disciplina pertinente para la traductología, se defienden las tesis correspondientes sobre la traducción como ente relacional, cuyo vínculo constitutivo con su texto original se expresa en las relaciones de no identidad y de dependencia ontológica, tanto en el “ser ahí” como en el “ser así”. Con esto se logra un esclarecimiento de la estructura ontológica de las traducciones interlingüísticas escritas.
Las nuevas conciencias: Feminismo y ambientalismo en el Movimiento Chicano
Authors: Martínez Martínez Mayra Jocelin , De los Reyes Patiño Reynaldo
Published: July 2024

El movimiento chicano surgió en la década de 1960 como reacción a la marginación y la violencia ejercida contra los mexicoamericanos en Estados Unidos, particularmente en zonas rurales y en el sistema educativo. En las décadas siguientes, aparecieron otras corrientes del movimiento como la chicana feminism y los ambientalistas, formando parte de una “conciencia oposicional” que contribuyó a su éxito y reproducción. En este artículo, analizaremos cómo estos movimientos se diferenciaron de sus vertientes hegemónicas al destacar su condición de subalternidad. A su vez, examinaremos cómo estas perspectivas han derivado en un trabajos académicos, desde la filosofía a la antropología y la ecología, que siguen una lógica similar, cuestionando los relatos hegemónicos y proponiendo alternativas que, aunque arraigadas en experiencias históricas específicas, tienen relevancia global.
Projeto Orla como estratégia de posicionamento para um destino turístico costeiro
Authors: Dantas Alves Albuquerque Wilisvete , Fernandes Ferreira Lissa Valéria , Oliveira Gonçalves da Silva Cavalcante Islaine Cristiane
Published: July 2024

Este estudo analisa a importância do Projeto Orla no marketing turístico e na promoção de Natal, no Rio Grande do Norte (RN). Foi realizado um estudo aprofundado sobre o gerenciamento e ordenamento da orla, com destaque para a praia de Ponta Negra/RN, um atrativo turístico relevante na categoria "sol e praia". O estudo é qualitativo, intencional, exploratório e descritivo. Foram conduzidas entrevistas com gestores públicos ligados ao comitê gestor do Projeto Orla. Como resultado, verificou-se que o marketing desempenha um papel crucial na melhoria dos serviços, aumentando a credibilidade junto à população, que espera resultados de excelência dos serviços públicos. Isso reforça o relevante papel do marketing na administração pública, por meio da interação entre os atores envolvidos, visando ao aprimoramento do desempenho dos serviços e à satisfação tanto da população quanto dos turistas. Conclui-se que é importante envolver e valorizar a população local, impulsionando a economia e gerando negócios, investimentos, empregos, renda e oportunidades para os moradores, sempre com respeito e preservação dos atrativos naturais. Este trabalho valida o papel relevante e influente do Projeto Orla no marketing turístico e na gestão pública da orla. Para estudos futuros, sugere-se investigar a implementação e atuação do comitê gestor municipal, bem como a responsabilidade dos setores envolvidos, visando à melhoria contínua da qualidade das estruturas e dos serviços, o que se refletirá no turismo e na qualidade de vida dos residentes.
Bulyying behavior in vocational school students in west sumatra province
Authors: Latupasjana Zikry , Firman Firman
Published: July 2024

The problem of bullying in high school students in the province of West Sumatra, the problems in this study are what are the characteristics, factors, impacts, and efforts that have been made by tutors in overcoming bullying behavior? The method used is a descriptive research method that is used is survey research. The research data are counseling guidance teachers, students, classes, parents, and school principals. Data collection techniques, interviews, observation, and documentation. The intermediary data used are interview guidelines, observation results, larger, and absent research results, there are already internal ones such as wanting to be in power and being seen as great, high self-confidence, rebels against themselves, while external factors are, adoptive parents, social environment children, unable to accept what they are facing and encourage students to take bullying and have a negative impact. What has been done is to provide orientation services, individual counseling information services.
Family, Friends and Colleagues' Support as Correlates of Job Performance among Non-Teaching Staff of Public Universities in Benue State: Implications for Counselling
Authors: Kpum Moses Mhide
Published: July 2024

The study investigated how family, friends and colleagues' support as correlates with job performance of non-teaching staff of public universities in Benue State for counselling implications. The study adopted a correlation research design. The population comprises 2,703 non-teaching staff from three public universities in Benue State: Joseph Sarwuan Tarka University in Makurdi, Benue State University in Makurdi, and the Federal University of Health Sciences in Otukpo. The sample size for the study was 348 non-teaching staff. The sample was selected using proportionate stratified and accidental sampling techniques. The instrument for data collection was a structured questionnaire titled “"Family Support, Friend's Support, and Colleagues' Support, and Job Performance Questionnaire" (FSFSCSJPQ). The questionnaire was validated by experts. The reliability of the questionnaire was established using Cronbach Alpha method which yielded coefficients of 0.81 and 0.84 for sections A and B respectively. Data collected for the study were analyzed using Pearson Product Moment Correlation Coefficient. The study's findings revealed that there is a high positive relationship between family support and job performance of non-teaching staff of public universities in Benue State, and that the relationship was significant. It was also found that, friends’ support and colleagues’ support had a high and significant positive relationship with job performance of non-teaching staff of public universities in Benue State. The study concluded that support networks, including family, friends, and colleagues; significantly contribute to the enhanced job performance of non-teaching staff in public universities in Benue State. Recommendation were made that public universities should organize employee assistance programs and workshops on communication and interpersonal skills using counsellors as facilitators to help build and maintain support networks and public universities in Benue State should establish or expand Counselling services for their non-teaching staff that can address both personal and professional challenges that may affect their job performance.
Urgensi kecerdasan emosional dalam meningkatkan prestasi belajar remaja
Authors: Pandri Desep Pria , Husna Fitratul
Published: July 2024

Prestasi belajar adalah kesempurnaan yang dicapai seseorang dalam berpikir, Prestasi belajar tidak lepas dari proses pembelajaran, pembelajaran adalah suatu proses yang kompleks karena remaja diharapkan tidak sekedar mendengar informasi, tetapi melibatkan diri secara penuh dalam berbagai kegiatan pembelajaran untuk menghasilkan pengalaman dan menyerap ilmu pengetahuan. Prestasi belajar dipengaruhi oleh faktor internal dan faktor ekternal. kecerdasan emosional  merupakan faktor internal  dan dukungan sosial orangtua adalah bagian dari faktor ekternal Penelitian ini bertujuan untuk menganalisis (1) Prestasi belajar, kecerdasan emosional, (2) kontribusi kecerdasan emosional secara sendiri-sendiri maupun secara bersama-sama terhadap prestasi belajar Remaja. Penelitian menggunakan metode kuantitatif jenis deskriptif korelasional. Populasi penelitian adalah Remaja kelas XI yang terdaftar pada semester ganjil tahun ajaran  sebanyak 436 remaja. Sampel penelitian sebanyak 209 Remaja, yang dipilih dengan teknik proportional stratified random sampling.. Instrumen menggunakan skala dukungan sosial orangtua, skala kecerdasan emosional dan hasil legger nilai Remaja. Data penelitian dianalisis menggunakan statistik deskriptif, regresi sederhana, regresi ganda. Temuan penelitian menunjukkan bahwa: (1) kecerdasan emosional berada pada kategori sedang,  (2) kecerdasan emosional berkontribusi terhadap prestasi belajar Remaja sebesar 31,5%, Implikasi hasil penelitian ini dapat digunakan sebagai bahan masukan untuk membuat program layanan konseling dalam meningkatkan pretsasi belajar remaja.