bluuebunny/crossref_metadata_2025 huggingface dataset:
Peculiarities of cerebral hemodynamics and cerebral bioelectric activity under infectious mite borreliosis
Authors: Cherepova O. V. , Gusakova S. V. , Zlobina M. V.
Published: April 2021

Cerebral hemodynamics state and peculiarities of bioelectric cerebral activity in patients with infectious mite borreliosis (IMB) have been investigated. 24 patients out of acute stage have been examined; the control group has been consisted of 10 healthy people. Values of rheographic index, index of vessel peripheral resistance, time of pulse wave spread, venous drainage index and elastic resistance index have been evaluated by rheoencephalography method (REG). ElectroEncephaloGram (EEG) has been registered in 12 abstractions according to the international system 10—20. Amplitude, frequency and indices of α-, β-, δ- and θ-rhythms, asymmetry degree and presence of paroxysmal activity have been evaluated. Use of EEG at patients with IMB has marked the α-rhythm suppression and increase of slow activity of δ- and θ-ranges, electric activity asymmetry and presence of paroxysmal discharges. By REG method there have been revealed expressed functional disturbances of cerebral circulation. Together with the impediment of venous drainage, this leads to the regulatory imbalance and the decrease of hemodynamic supply to separate cortex parts that may be a reason of bioelectric cerebral activity disturbances in patients with IMB.
Pharmacological incompatibility
Authors: Vengerovsky A. I.
Published: April 2021

In the lecture there have been studied pharmacokinetic and pharmacodynamic mechanisms of drug undesirable interaction at combined pharmacotherapy and have been cited the urgent for general practitioner examples of pharmacological incompatibility.
Hepatic cryosurgery in experiment and clinic
Authors: Alperovich B. I. , Potapov A. V. , Salo V. N.
Published: April 2021

The aim of the investigation – to study changes in hepatic tissue resulting from the influence of low temperatures (– 195,8 °C) in experiments and clinic. Hepatic tissue investigations in experiment have been carried out using electron and light microscopy. During the surgery instruments of original design have been used – cryoscalpels and cryodestructors. Experiments have been carried out on 45 sexually mature dogs of both sexes. Animals have been separated into 3 groups. On the first group (consisting of 12 animals), in the acute experiment, there have been studied features of cryoscalpel design characteristics. In the second series of experiment (on 22 dogs) there have been made a comparative study of hepatic resection using cryoultrasonic scalpel and simple surgical scalpel by means of the study of hemorrhage quantity. In 11 cases there have been studied hepatic morphological changes affected by cryoeffect. By the effect of low temperature ice crystals are appeared in hepatic tissue intracellularly and outside the cell, they cause mechanical injury and rupture of hepatic tissue. In 45 days connective tissue elements are formed at the place of cryodestruction. The use of cryoultrasonic scalpel in hepatic resection in the experiment decreases the hemorrhage quantity by 1,26 times as compared to the traditional methods. Positive experimental investigations allowed to use the low temperature with success in clinical practice at 253 patients with different localized hepatic diseases with 13 lethal outcomes (5,1%). Thus, the used cryosurgical technique during surgical operations allows to decrease significantly the hemorrhage, to eliminate parenchymatous bleeding and to prevent relapses of disease both at growths and at parasitic hepatic affection.
Physical factors for medical rehabilitation of patients with Lyme-borreliosis
Authors: Ryeshetova G. G. , Titskaya Ye. V. , Zaripova T. N. , Pyerova T. B. , Shevtsova N. M. , Shakhova S. S. , Dostavalova O. V. , Shevtsova O. V.
Published: April 2021

Investigations made on 96 patients with chronic Lyme-borreliosis accompanied with predominant joint affection have allowed to ground scientifically an advisability of two-stages treatment, with administration of physical factor complex at the second stage. A treatment technology has been developed that allowed to improve significantly the state of 82,4% of patients with good tolerance.
Result catamnesis of the treatment of patients with acute Lyme mite borreliosis
Authors: Dobkina M. N. , Lepyekhin A. V. , Zhukova N. G. , Lukashova L. V. , Zaviyalova G. N. , Kiyutsina T. A.
Published: April 2021

The aim of the work is to study the efficiency of different antibacterial medication combinations for the treatment of patients with acute Lyme mite borreliosis. 156 patients aged 20—76 have been on regular medical check-up. Different penicillin and tetracycline antibiotics have been applied as well as cephalosporins of 1 and 3 generation. The treatment duration has been 7—14 days. The duration of general intoxication syndrome, terms of clinical symptom dissapearance, antibody titer dynamics in indirect immunofluorescence reaction with borreliosis antigen, presence of side actions and long-term results of the treatment have been taken into account in the evaluation of different antibiotic combination efficiency. 1 year after discharge from the hospital 69,2% of observed persons considered themselves healthy, 15,4% obtained the diagnosis of chronic clinical LMB with predominant joint or nervous system damages. Thus, analysis of the investigation result shows that currently used etiotropic therapy regimens are not sufficiently effective. They allow recovery of 69,2% of patients with acute Lyme mite borreliosis only.
Consequences of colectomy: pathogenetic damages and correction outlooks
Authors: Bashirov S. R.
Published: April 2021

On the base of experimental and clinical investigations there has been found that continent reservoir ileorectostomies after colectomy under the rectal contents effect had been exposed to degenerative and dysplastic mucous changes. These damages prohibit from stool formation and increase the risk of reservoir malignization. A method of continent reservoir ileorectostomy formation with restraining and areflux mechanism has been developed for pathological transformation of ileal structure. Results of morphological and instrumental investigation methods made on 33 dogs and 6 patients after colectomy show that the restraining and areflux mechanism permits to avoid displastic and degenerative changes in ileal reservoir mucous coat and to recover the stool formation due to motor-evacuation function regulation and keeping the constant physical, chemical and bacterial reservoir and rectum properties after colectomy.
Strictures of biliary tracts during opisthorchosis
Authors: Brazhnikova N. A. , Tskhay V. F.
Published: April 2021

1170 patients with chronic opisthorchosis have been operated by surgeons of Tomsk hepatology center for 35 years, 4756 patients have been treated. In 730 operated patients different strictures of biliary tracts have been revealed, strictures of cystic duct have been observed in 372 patients (51%), strictures of choledoch distal section and major duodenal papilla (MDP) of expanded character — in 124 patients (17%), stricture combination — in 205 patients (28%) and sclerosing cholangitis — in 29 (4%). The treatment of opisthorchosis strictures of biliary tracts is surgical. In case of any its localization a cholecystectomy is necessary, in case of strictures of choledoch distal section and MDP a supraduodenal choledochoduodenostomy is necessary. In early postsurgical period it is prescribed an anthelmintic therapy with iodinol through external drainage of bile ducts. Good farther results have been marked at 79,4% of patients.
Relief of the pain syndrome in patients with disseminated prostate cancer
Authors: Leonov O. V. , Dolgikh V. T. , Lukach V. N. , Shirokorad V. I. , Demin D. I. , Kopyltsov Ye. I. , Volodin I. A. , Dolgikh D. V.
Published: April 2021

In the present investigation it has been foreseen to develop pathogenetically founded methods of the chronic pain syndrome relief in patients with disseminated prostate cancer. 47 men with the prostate cancer of III—IV stage have been examined and treated. It has been stated that either a long-term epidural sensory block created with hydrochloride morphine or anekaine, or an intrathecal hormonotherapy with synesthrol and hydrocortisone had significantly decreased the pain syndrome and the level of prostatespecific antigen in blood serum, had significantly improved the urodynamics increasing an average and maximum rate of urine flow and urine volume, reducing the time of urination, and had improved the patients’ life quality by 17—30%.
Peculiarities of blood rheology in patients with chronic generalized periodontitis combined with gastrointestinal tract disturbances
Authors: Kiritchuk V. F. , Shirokov V. Yu.
Published: April 2021

The aim of investigation is to study blood rheological properties in patients with chronic generalised periodontitis combined with gastrointestinal tract disturbances. 205 patients have been examined including those with erosive ulcerous involvement of gastroduodenal area — 51, with stomach ulcer and duodenal ulcer — 62, with chronic colitis — 39, with nonspecific ulcer colitis — 53. Blood viscosity properties, indices of erythrocyte aggregation and deformability, rate of oxygen delivery to tissues have been evaluated by rotary viscometer АBR-2 (Russia). It has been revealed that blood rheological properties in patients with chronic generalised periodontitis combined with gastrointestinal tract disturbances had been disturbed, that was accompanied with the blood viscosity rise, erythrocyte aggregation increase and with the decrease of deformability and rate of oxygen delivery to tissues. The degree of violations in blood rheology indices was mostly expressed under chronic and plural erosions of gastroduodenal area, duodenal ulcer and severe course of chronic nonspecific ulcer colitis.
Detection of children with bronchopulmonary pathology and risk of its forming using the «EDIFAR» computer system
Authors: Zabolotskikh T. V. , Mizernitsky Yu. L. , Dartau L. A.
Published: April 2021

In the article it has been shown the efficiency of children detection with bronchopulmonary pathology and risk of its forming using the «EDIFAR» computer system. Screening with this computer technology allows in short terms a pictorial view of children’s health on the primary health service territory. This investigation has been made in pediatric polyclinic ‹ 4 in Blagoveshchensk. The results show the actual prevalence of respiratory diseases at children aged 0—7 years and are an evidence of a significant exceeding of disease indices as compared to the official statistic data. Information get with the computer system is necessary not only for address aid but is useful in conditions of insurance medicine and market principles of funds spending for health protection as well.
Functional-morphological changes in small intestine in early post-resuscitation period
Authors: Konyaeva T. P. , Dolgikh V. T. , Yelomenko S. N.
Published: April 2021

The aim of investigation is revelation of regularities of post-resuscitation parietal digestion disturbances based on the study of small intestine mucous tunic. 5-minute apparent death by sharp bloodletting has been simulated at 40 rats. They have been used in 30 and 90 minutes; 3 and 6 hours after resuscitation for the study of small intestine mucous tunic with the methods of: 1) enzyme step-desorption; 2) perfusion in vivo; 3) section coloration by hematoxylin-eosin. In 30 minutes after the resuscitation the activity of all amylase fractions has risen sharply: activity of abdominal fraction — by 52%, of desorbed fractions — by 67% and of intracellular fraction — by 26% regarding to the control level (p < 0,001). In 3 hours the activity of amylase abdominal fraction has increased by 79% and activity of intracellular fraction has, on the contrary, decreased by 23% up to the control level (p < 0,001). These changes have prevailed in proximal part of small intestine that was connected with the peculiarities of its blood supply and innervation. In the early post-resuscitation period two picks of amylolytic enzyme activity have been observed. They are connected with the processes of ischemia-reperfusion in pancreaticoduodenal area and the morphological changes of mucous tunic confirm visually the increase of permeability in proximal parts of small intestine.
Some characteristics of the treatment of generalized and disseminated renal cell carcinoma
Authors: Leonov O. V. , Dolgikh V. T. , Shirocorad V. I. , Kopyltsov Ye. I. , Dolgikh D. V.
Published: April 2021

In the article 206 treatment results of generalized and disseminated renal cell carcinoma are presented. It has been found that disseminated forms of hypernephroma required a combined surgical treatment without fail; nephrectomy added by adrenalectomy is recommended insuperpolar tumour localization. Combined surgery with resection or ablation of the affected organ seems to be advisable in disseminated renal cell carcinoma. Such an active surgical approach improves the prognosis. Medicamental antineoplastic therapy including immunotherapy in postoperative period can raise patients survivability and quality of life.
Antimutagenic activity of the Siberian herbs
Authors: Yefimov S. N. , Dmitruk S. I. , Ilyinskikh N. N.
Published: April 2021

The antimutagenic activity of 41 Siberian herbs has been studied with microcores analysis method (calculation of micronucleous erythrocyte number in peripheral blood of mice). The most active species have been composed in herb preparations and the preparation with the most activity has been revealed with microcores analysis method. The microcore number decrease has been observed up to 1,80‰. Antimutagenic herb preparation activity is defined by the content of vitamins, pigments, coumarins, polyphenol complex, flavonoids, terpenic saponins, lactones and other compounds.
Historical and modern preconditions to the creation of social work faculty in Siberian State Medical University
Authors: Kornetov N. A.
Published: April 2021

Historical and modern data of the need of the creation of social work faculty in Siberian State Medical University is discussed in the present paper. The need of university education renovation in the sphere of mental health protection is a ground of the social specialist training. It is suggested a development of biopsychosocial education model that requires the training of social workers in the sphere of clinical psychology, psychotherapeutic supports and psychiatry. The analysis of the current state of social service efficiency in Russia reveals the need of the training of new generation specialists for the development of the social net, social assistance, support and rehabilitation of persons having temporary or chronic mental and behavioural disorders or in crisis living situations.
Quality performance of medical service in rural treatment-and-prophylactic institutions in Tomsk region
Authors: Zakotnova N. V.
Published: April 2021

Rural treatment-and-prophylactic institutions (TPI) and mainly central regional hospitals (CRH) – the key rural health protection units – insufficiently control and improve the medical service system quality due to a number of reasons. In rural CRH a number of incomplete examination cases and, consequently, a number of wrong diagnosis cases is higher significantly. Incomplete treatment becomes evident in rural areas more frequently as well. As a result the treatment quality in rural CRH is lower significantly than in Tomsk TPI. It is necessary to draw a special attention to the problem of rural medical service quality increase and to liven up the control of privided medical service quality in regional centers.
A.A. Opokin – an outstanding Siberian surgeon (to the 125th birthday anniversary)
Authors: Nekrylov S. A. , Ronzhin S. G.
Published: April 2021

The life of the outstanding person, famous Russian and Soviet surgeon Alexander Alexandrovich Opokin is a striking example of whole-hearted service to the Motherland and medicine. Being a pioneer of thoracic and oncologic surgery in Siberia, a brilliant field-military surgeon and a teacher of a whole pleiad of disciples, he has contributed a lot into the development of domestic surgery. The 125-th birthday anniversary A.A. Opokin is a significant reason to recall his name and actions, to bow down before him and to compare the own life guiding line.
Peculiarities of inflammatory response during collagenosis
Authors: Trofimenko N. A. , Zorina V. N. , Arkhipova S. V. , Gorbatovsky Ya. A. , Zorina R. M.
Published: April 2021

Concentrations of cytokines (IL-1β, IL-6, TNF-α) of α2-macroglobulin (MG), α1-antitrypsin (AT) plasminogen (PL), whole protein, albumin and uric acid in blood serum of patients with collagenosis have been investigated aiming the study of their complex interaction and the possibility of their use during differential diagnostics. The blood serum of 60 healthy donors, 53 patients with rheumatoid arthritis (RA), 15 patients with reactive arthritis (REA) and 16 patients with systemic lupus erythematosus (SLE) has been studied. IL-1β, IL-6 and TNF-α concentrations have been defined by ELISA, MG, AT and PL-rocket immunoelectrophoresis, the whole protein, albumin and uric acid — by biochemical methods. The albumin level decreased in all groups of patients. The whole protein concentration decreased at the first RA activity degree. MG, AT and PL levels had no difference at all diseases as compared to the control group. IL-6 concentration increased significantly at all patients groups. TNF-α increased with the RA severity but differed statistically significantly from REA and SLE only at the most severe degree. Analogous trends in IL-1β concentration have been found in cases of RA and SLE but at REA great individual fluctuations with the high average level have been found. Synchronous change of the studied cytokine concentrations without associated MG level change is evidence of the damage of traffic and regulatory functions of this protein. The uric acid can be used for SLE diagnostics and the dynamic supervision of IL-1β and TNF-α can be a prognostic criterion at RA.
Peculiarities of ageing at patients with stomach ulcer
Authors: Vavilov A. M.
Published: April 2021

The aim of investigation is to compare the rate of ageing at patients with stomach ulcer (SU) and of practically healthy people. Dynamics of biological age of 406 patients with SU aged 40—59 years and of comparable practically healthy groups has been observed. The ageing of patients with peptic mediagastric pyloroduodenal ulcers develops faster than of practically healthy people. The rate of ageing at patients with peptic mediagastric pyloroduodenal ulcers depends on the clinical course and effected therapy.
Hematosis regulation theory
Authors: Dygai A. M.
Published: April 2021

It has been revealed that blood system changes observed under the impact of pathogenic factors, different by their nature, and mechanisms laying in their basis were, in many respects, of the same kind. However the specific blood system response is defined by the nature of the acting exciter owing to specific changes in regulation structure functioning. Therefore changes in white blood, and at the acute hemorrhage – in red blood, prevail at inflammation during stress along with the proportional stimulation of different medullary hematosis outgrowths. Repeated extreme impacts lead to the emaciation of adaptive abilities of hemopoietic tissue as a result of the expressed hemopoiesis rocess irregulation.
Organization of field medical aid for the population of northern areas of Tomsk region
Authors: Solomatina T. V. , Chernova N. A. , Pershina S. A. , Engel Ye. E. , Kapilevich L. V.
Published: April 2021

Field medical aid is most effective in providing the population of northern areas of Tomsk region with qualitative and accessible medical services. Development of such organization form is the most perspective way of health protection system perfection in the region. The most results will be achieved while providing the interaction and coordination of the activity of territorial treatment-and-diagnostic institutions and field medical teams. The field forms of aid should complete the activity of regional hospitals, provide the accessibility of medical services in remote areas and equalize the quality of medical aid in areas particularly regarding high-tech treatment-and-diagnostic procedures.
The present vaccinoprophilaxis of tick-borne encephalitis and vaccines for its provision
Authors: Vorob’Eva M. S. , Rashchepkina M. N. , Pavlova L. I. , Bystritsky L. D. , Stavitskaya N. H. , Iltchenko T. E. , Bilalova G. P. , Mishchenko I. A. , Sharova O. I.
Published: April 2021

The high rate of tick-borne encephalitis (TBE) morbidity is lasting for recent years in many areas of Russian Federation. Vac- cination with TBE vaccine is considered to be most effective mean of TBE prophylaxis in endemic areas. VIRION branch (in Tomsk) of MICROGEN State Company have been producing inactivated TBE vaccines for more than 40 years. Since 2001 VIRION have been producing and selling novel purified concentrated TBE vaccine EnceVir. Vaccine EnceVir contains inactivated TBE virus of Far Eastern subtype as active substance with high level of its purity. The vaccine substantiated high level of immuno- genicy and safety in adult and children clinical trials. Postmarketing surveillance during 2001—2005 has verified these conclusions. Hence EnceVir is effective, safe and most available regarding value vaccine for mass vaccination campaign in Russian Federation.
Diversity Borrelia burgdorferi sensu lato in natural foci of Novosibirsk region
Authors: Fomenko N. V. , Romanova Ye. V. , Karavaeva Yu. Yu. , Panov V. V. , Chernousova N. Ya. , Livanova N. N.
Published: April 2021

PCR assays were used to test sample from Ixodes persulcatus, blood and tissues of small mammals, human blood after tick bi- tes, as well as isolates from adult ticks. It was demonstrated the presence of two Borrelia species: B. garinii and B. afzelii. Mainly DNA B. garinii NT29 were determined.
«The life to the emperor, the honour - to nobody»: The moral choice of the Yeugeniy Sergeyevich Botkin (to 140th anniversary of the birthday)
Authors: Ronzhin S. G. , Ryazantsev A. A. , Ronzhin I. S.
Published: April 2021

Twenty three steps down the basement of the Ipatiev house in Ekaterinburg, the steps into the chasm and the darkness, the movement into the immortality. The moral choice of the last emperor's physician, doctor Yeugeniy Sergeyevich Botkin - it is the choice of the nobleman officer, patriot and the citizen, the choice of autocratic and God-carried Russia romantic. The changes of the governments and epochs as well as of the partialities and the values are possible, but the admiration from the Russian intellectual's soul's force, with his vulnerable conscience is invariable example. The honour - to nobody, never and in spite of any difficulties - the simple and the attractive formula of the doctor's Botkin fate.
The detoxication peculiarities by microsomal oxidation enzymes and glutathione dependent enzymes under pseudotuberculosis at children
Authors: Zhavoronok T. V. , Nosareva O. L. , Pomogayeva A. P. , Butusova V. N. , Starikov Yu. V. , Klimanova Ye. M. , Petina G. V. , Stepovaya Ye. A.
Published: April 2021

There was evaluated detoxication function state by the antipyrine test and glutathione dependent enzymes activity among the children with combined form of middle-degree pseudotuberculosis of sharp smooth tendency. Liver disorder was proven by the clin-ical and biochemical approaches. Our results show that it is desirable to allow detoxication biochemical processes peculiarities un-der Yersinia pseudotuberculosis infection while determining disease prognosis.
Integration of cardiac rhythmogenesis levels: cardiac rhythm generator in the brain
Authors: Pokrovsky V. M.
Published: April 2021

Data which were obtained last time allow to re-comprehend ideas concerning mechanisms of cardiac rhythm regeneration and demonstrate existence of rhythm generator in the central nervous system in addition to such in the heart itself. Intracardiac generator is a life-supporting factor which supports pumping function of the heart while central nervous system is in deep inhibition status. Central generator provides adaptive reactions of the heart in natural medium. Integration of the two hierarchic levels of rhythmogenesis provides reliability and functional perfection of cardiac rhythm generation system in the organism.
Mechanisms of bronchial asthma control disturbance in using 2-agonists
Authors: Vas'kovsky N. V. , Koulikov Ye. S.
Published: April 2021

Despite exclusively high clinical efficacy of 2-agonists in bronchospasm, their regular using is associated with increased level of bronchial asthma control and the development of severe and life-threatening states which in turn is associated with increasing bronchial hyper-reactivity, development of partial tolerance, increased allergic load and masking of the disease aggravation. Deve- lopment of tolerance to 2-agonists and increasing sensibility of bronchi to bronchoconstrictive stimuli are based on specific mecha-nisms including desensitization of 2-adrenoreceptor, increasing expression of C phospholipase and mechanisms associated with gene AP variants which are not studied enough.
Factor analysis in maternal mortality study in Omsk region in 1995-2003
Authors: Fyodorova G. V. , Butova E. A. , Banyushevich I. A.
Published: April 2021

Practice factor analysis, information statistical method based on K. Iberle theory (1980) are presented in the article. With the method the factors which influence on maternal mortality were scientifically proved. The factors have been ranged and the most es-sential were exposed. The data obtained may be abailable in working out measures to decrease a maternal mortality rate - an index which characterizes to a certain extent the guality of functionaling in the region health care system.
Mechanisms of psychological defense and strategies of control stress of mothers who have children suffering from cerebral paralysis
Authors: Kolpakova L. M.
Published: April 2021

The problem of studying adaptive potential of mothers who have children with cerebral paralysis is considered which may be useful for the choice of diagnosis and preventive accesses in the framework of preventive measures directed to the prevention of disturbances of personality and diseases under stress events of life. Analysis data of mechanisms’ structure of psychological defense in the age dynamics compared to control group of women having healthy children. Psychological adaptive mechanisms are differentiated which help to transform negative internal emotions into more adequate form taking into account specificity of the situation in which mothers with such children are. Mechanisms of controlling behavior are revealed which have preventive function and increase personal resources of women-mother in the situation of stress events which are associated with her child disease.
More than 30 years later
Authors: Goldberg D. I.
Published: April 2021

The earlier not published appearance of professor D.I. Goldberg in the meeting of graduating students of 1929 of medical faculty of the Tomsk State University which was held in Moscow in 1963.
Morphologic changes of retina cellular elements under long low intensity light exposure
Authors: Logvinov S. V. , Varakouta Ye. Yu. , Potapov A. V. , Mikhoulya Ye. P. , Zhdankina A. A.
Published: April 2021

Structural changes of eye retina in 40 male white rats under the influence of light with intensity of 200 lk during 1, 7, 14 and 30 days were studied using electron microscopy method and morphometric analysis. Structural changes of all cell elements of retina were revealed which were particularly expressed in neurosensory cells and in radial gliocytes. Maximum number of neurosensory cells with destruction of nucleus was observed after 7 days of exposure and achieves its maximum (4,6 ± 0,3)% compared to controls (0,40 ± 0,02)%. Changes of radial glial cells have both regressive and progressively -proliferative character. Changes of neurons of retina internal layers have mainly reversible character.
The role of opioid peptides in the regulation of secretin-stimulated bile secretion
Authors: Medvedev M. A. , Roudin I. V.
Published: April 2021

Influence of intraperitoneal dalargin (dand m-opioid agonist), DADLE (d-opioid agonist), DAGO (m-opioid agonist) and U50488 (k-opioid agonist) on bile secretion which is stimulated by secretin was studied in sharp experiments on white rats. All opioids studied is demonstrated to suppress secretory response of liver upon secretin in different extent. We suppose that opioidergic regulation system has different effect on bile secretion in dependence of baseline level of physiologic secretion.
Diagnosis of osteopenic syndrome. Osteopenic syndrome in bronchial asthma patients
Authors: Zorkaltseva O. P. , Zavadovskaya V. D. , Kobyakova O. S. , Kilina O. Yu. , Nigmatova E. Sh.
Published: April 2021

Osteopenic syndrome in chronic obstructive pulmonary diseases including bronchial asthma represents actual and insufficiently studied area of medical science in view of ambiguous data on influence of glucocorticosteroid therapy and inflammation as basic pathogenetic mechanisms of bronchial asthma on bone metabolism. This review covers issues of pathogenesis and diagnosis of secondary osteopenic syndrome in patients with bronchial asthma.
Phenomenology and classification of food behavior disturbances (literature review, part I)
Authors: Romatsky V. V. , Syomin I. R.
Published: April 2021

Literature data of epidemioloc character concerning prevalence of food behavior disturbances in the historical aspect are presented in the review. Modern diagnosis signs of this form of pathology are described, criteria of their perfection are discussed. The very high percent of comorbidity of food behavior disturbances with psychic and somatic disorders is noted by home and foreign authors.
Chronobiologic aspects of fetus sex differentiation
Authors: Kalentyeva S. V.
Published: April 2021

The analysis results of 5 213 delivery histories revealed that number of newborn boys was 10 percents more than number of newborn girls. During first pregnancy, conception of boys is more probable in autumn and during the 4-6 months after mother’s birthday. During repetitive pregnancies, conception of boys is more probable in spring and during 3months before mother’s birthday. Conception of boys prevails in young mothers especially in winter and 1-3 months before mother’s birthday. Conception of girls occurs in older women generally more often but conception of boys is more possible in spring and during first 3 months after mother’s birthday.
Polymorphism of chemokine receptor gene CCR5 in multiple sclerosis patients and in healthy subjects in the Siberian region
Authors: Orlova Yu. Yu. , Alifirova V. M. , Cherdyntseva N. V. , Gervas P. A.
Published: April 2021

Multiple sclerosis is chronic inflammatory disease of the central nervous system in the development of which chemokines of the type Tx1 play the leading role. Chemokines and their receptors participate in the development of multiple sclerosis as a result of drawing immune cells into central nervous system. Mutation of CCR5 delta32 decreases functional activity of the appropriate receptor on cellular surface and thus can reduce migration of leucocytes into foci of injury. Aimed at studying the role of mutation in multiple sclerosis, we compared frequency of gene type CCR5 in peripheral mononuclears of 102 multiple sclerosis patients and in 136 healthy subjects. The results obtained allow to conclude that polymorphism of chemokine receptor gene CCR5del32 is not a leading factor in the susceptibility to multiple sclerosis in the studied population.
Whether the intraoperative irradiation influences the life quality of lung cancer patients?
Authors: Khodkevich B. S. , Zaviyalov A. A. , Miller S. V.
Published: April 2021

The life quality of patients with lung cancer after the intraoperative irradiation with a dose 15 Gy during the surgery (loband pneumonoectomies) for the period of two years has been studied. The form developed by the European Organization for Research and Treatment of Cancer EORTC QLQ-C 30 and the QLQ-LC 13 module were used. It is shown that the life quality of patients with lung cancer after combined therapy is determined mainly by the volume of surgery made, rather than by the adjuvant therapy conducted. Of great importance for patients was the period needed for the adaptation of the organism to new living conditions. In general, no significant differences in the main life quality indices were revealed among patients of both groups. Based on the results obtained, one can say that the addition of surgery with intraoperative radiotherapy with a total focal dose 15 Gy does not lead to the considerable worsening of life quality of patients and can be recommended for clinical application.
Attitude to illness in pancreatic diabetes patients
Authors: Petrova M. M. , Rachko T. A.
Published: April 2021

The study of the psychological status of 224 type 1 and 2 pancreatic diabetes (PD) patients has revealed the dominant types of the attitude to illness. In type 1 PD patients, regardless of the sex, the dominant type was ergopatic, which may lead tounsatisfactory results of treatment. However, the anosognosiс type of attitude was observed reliably more often in men with type PD than in women. In type 2 PD patients, the harmonic type dominated. At the same time, the disturbing type was observed in women, but not diagnosed in men with type 2 PD.
Assessment of the incidence of Opisthorchis felineus (Rivolta, 1884) and Metorchis bilis (Braun, 1890) infections in population of several regions of the West Siberia
Authors: Ilyinskikh Ye. N. , Novitsky V. V. , Ilyinskikh N. N. , Lepyokhin A. V.
Published: April 2021

The incidence of Opisthorchis felineu s (Rivolta, 1884) and Metorchis bilis (Braun, 1890) infections among people lived in several regions of the Ob-Irtysh River basin in the West Siberia has been assessed. Our results suggest that Metorchis bilis infection was common in many of the serologically tested people. Moreover, this helminth was obtained from the biliary ducts of humans in autopsy.
The ultrasonic characterization and functional status of a thyroid gland in the population living in ecologically unsuccessful region
Authors: Afanasyeva S. A. , Gouzhikhina Ye. Ye. , Kravets Ye. B.
Published: April 2021

The problem of iodine deficiency has serious consequences for physical, intellectual, and reproductive health of the population. Tomsk falls in the group of mixed ecological regions, in which high anthropogenic pollution of the atmosphere is observed along with the slight iodine deficiency. The results of the analysis of the volume, structure, and functional status of a thyroid gland at 114 children and teenagers and 101 adult patients are presented. The combined examination included clinical inspection, ultrasonic study, and hormonal investigation of the thyroid gland. It was found that the structure of the thyroid gland deteriorates with age and the transformation of the diffuse goiter into the nodular one increases.
Modeling methodology of correlations inconvertibility, complexity and information processes
Authors: Melik-Haikazyan I. V.
Published: April 2021

Considering the postneclassic methodology concepts (V.S. Stepin) the information-synergetic approach (I.V. Melik-Haikazjan) was worked out. The main point of the approach can be seen in the following statements: information is the inconvertible multi- phase process; information processes are the mechanism of complex systems self-organization. Within the frames of the approach there is a capability to construct models relevant to dynamics of complex systems, including socio-cultural systems. The mechanism of complex systems self-organization revealing clarifies the correlation of the system functions and cultural configurations. Thus the permissible limits of axiological and ethical transformations can be defined, when innovations do not bring inconvertible damage to human universe.
Philosophy of developing harmony as a principle approving the bases of medical anthropology
Authors: Vidgof V. M.
Published: April 2021

The article reveals the methodological potential of system principle of developing harmony used to approve the bases of medi- cal anthropology.
Health and pathology: biomedical and humanitarian aspects
Authors: Kochergin A. N.
Published: April 2021

В статье обосновывается необходимость выделения из суммы антропологических учений биомедицинской антрополо- гии. Обсуждается предметная область и концептуальные основания биомедицинской антропологии.
Human responsibility in postmodernistic culture
Authors: Vetoshkina I. V.
Published: April 2021

The article deals with essence and specification of responsibility phenomenon in postmodern culture.
The interrelation dynamics of Fundamental Science and Society (on an example of nanotechnology)
Authors: Zhoukova Ye. A.
Published: April 2021

This article represents the results of the research granted by RFFS № 04-06-80192. The high technologies foundation is based on fundamental research. Inclusion of bioethical and environmental problems in a context of scientific activity becomes the specifics of a modern science. Nanotechnology fundamental researches lead to a change of the world picture, which bases now on the laws of quantum mechanics. Creating nanotechnology, a person enters competition with the nature as aspires to receive the control over mi- croscopic processes and structures, although himself can become a slave of nanotechnology.
Clinical-economic analysis of morphologic diagnosis methods of irreversible myocardial changes aimed at selecting optimal strategy of surgical treatment of ischemic cardiomyopathy patients
Authors: Kalitvyanskaya T. A. , Yusoubova Ye. V. , Kazakov V. A. , Soukhodolo I. V. , Shipoulin V. M.
Published: April 2021

The aim of the study was performing clinical-economic analysis of the assessment methods of morphologic-functional status of left ventricular myocardium in ischemic cardiomyopathy patients. The assessment of expenses of morphologic study methods of before operation and intra-operation diagnosis of myocardial dysfunction irreversibility stage was done. Method of minimizing ex-penses was chosen to analyze these two approaches. Comparative analysis of morphologic methods showed that the most economi-cally profitable is before operation method. The economic assessment was performed for optimization of morphologic studies in the work of cardiovascular surgery department of the Institute of Cardiology, TSC RAMS (Tomsk). The necessity of myocardial dys-function state analysis is due to the selection of optimal approach to surgical treatment of ischemic cardiomyopathy patients or re-vealing contraindications to it.
The role of potential staying duration of the cells in peripheral blood
Authors: Svischenko V. V. , Stakhin N. A.
Published: April 2021

For evaluation of potential staying duration of cells in peripheral blood on the character of cell kinetics, method of mathemati-cal modeling was used. Potential staying duration of cells in peripheral blood was numerically shown to deeply influence on anemia, but only for the small share of cells' death.
Cytochemical and mycrobicide activity of blood phagocytes in pulmonary tuberculosis patients
Authors: Filinyuk O. V. , Zemlyanaya N. A. , Strelis A. K. , Ourazova O. I. , Voronkova O. V. , Shevtsova N. M. , Yesimova I. Ye.
Published: April 2021

Aimed at non-specific reactivity of the organism, cytochemical activity and microbicidal properties of blood neutrophils and peripheral blood monocytes were studied in 102 patients with drug-sensitive pulmonary tuberculosis before the treatment, after in-tensive phase of therapy and after stopping anti-tuberculosis therapy. Increased hydrolytic enzymes' activity of leucocytes, levels of non- cationic proteins and decreased levels of cellular glycogen and induced NBT-test were observed without their dependence on drug-sensitivity of mycobacterial tuberculosis before and during the treatment.. At the same time, content of lipids in neutrophils and monocytes undergoes different changes.
Hormonal-immunologic status and peculiarities of nourishment in obese subjects
Authors: Troshina I. A. , Petrov I. M. , Gagina T. A. , Medvedeva I. V. , Maleyev V. V.
Published: April 2021

Nourishment peculiarities of 120 patients aged from 41 years having excess body mass and obesity were investigated. Interre-lations with changed hormonal-immune status were assessed. Method of food taking rate developed in the Institute of Nourishment, RAMS, taking into account nourishing peculiarities of Russian population was used. Study results revealed, that patients had imbal-ance concerning main macro- and micronutrients: nourishment regimen was disturbed in 90% of cases, taking main part of energy value was shifted to the second half of a day, increased calorie content of nourishment, excess of monosaccharides in the setting of decreased physical activity were seen which plays the main role in the development and advancing obesity, increased level of leuco-cytes, of TNF-α, IFN-γ, humoral immunity link imbalance, increased serum concentration of leptin and insulin which is closely cor-relates with excess body mass and nourishment peculiarities.
The aging rates and antioxidative status of workers in conditionof the industrial influence of xenobiotics
Authors: Maksimov S. A.
Published: April 2021

The purpose of the investigation is studying aging rates and antioxidative status of workers the influence of industrial xenobiotics. 833 workers are examined for biological age, activities of antioxidative ferments, concentration of the peroxidation products. The general regularities of the influence of industrial factors on the studied processes are established. The unfavorable influence is noted in workers with long length of service subjected to the influence of the xenobiotics in concentrations corresponding to class 3 degree 3-4.
Morbidity analysis of youth due to call-up of the Tomsk region
Authors: Astankin S. V.
Published: April 2021

The 2-fold increase of pre-conscription youth and youth due to call-up morbidity is noted in Russian Federation during past decade. While recruiting of troops, for about 60% of the youth due to call-up were attributed to the 1-st group of health. More than 40% of the youth can not bear exercise which occurs during military labor. Index of unfitness to military service increased from 5.5 to 35% in the West Siberian regions. Armed forces are recruited with significant share of subjects having signs of protein - energetic insufficiency. All this necessitates studying condition of health and physical development of pre-conscription youth and youth due to call-up aimed at assessing causes of aggravated health and developing preventive measures in this category of mens population of the country.
Application of a system of immune status complex inspection in personnel ofchemical production
Authors: Radzivil T. T. , Oradovskay I. V. , Antipin V. T.
Published: April 2021

Screening examinations of chemical industry workers aimed at early revealing immunodeficiency status, subclinical forms of thyroid gland diseases, oncologic diseases, diseases of a gastrointestinal tract and pathology of mammary glands. Levels of a thyrotrophic hormone (TTH) and of free thyroxin, oncologic organ-specific markers, basic subpopulations of lymphocytes were determined blood serum. The study results revealed basic immune-pathologic syndromes which require immune corrective measures in practically healthy people; subclinical forms of thyroid gland diseases, cancers of various localization. Necessity of introduction the given kinds of studies in periodic medical surveys which are annually performed in enterprises nuclear industry.
Assessment of pulmonary mechanical properties influence on patternsand indices of their ventilation mechanics in various biologicalconditions
Authors: Karzilov A. I. , Tetenev F. F. , Bodrova T. N.
Published: April 2021

Patterns and mechanics of pulmonary ventilation are studied in sharp experiment on living rabbits (n= 15), after their sacrificing (n= 15) and on isolated lungs (n= 7). The data obtained revealed that mechanical properties of lungs and thorax - pulmonary integrity influence on forming patterns and parameters of lung mechanics during their ventilation independently regulatory influences of living organism. Classical Donders model of lung operation is incorrect for considering mechanical processes of lung ventilation because it take into account influence of mechanical lung properties and a thorax on forming patterns and parameters of ventilation mechanics.
Innovations in medicine and patent right
Authors: Zoubareva N. G.
Published: April 2021

The aim of the article is to show some problems which occur in the process of innovation activity in medicine and ways of their possible solution using the patent right norm.
Main complications after major liver resections and possible waysof prevention
Authors: Fyodorov V. D. , Vishnevsky V. A. , Nazarenko N. A. , Ikramov R. Z. , Kozyrin I. A.
Published: April 2021

Results of 325 major liver resections were investigated. The common indications were malignant and benign lesions, hydatid cysts, purulent cholangitis, posttraumatic liver necrosis. The main complications after liver resections were massive intraoperative bleedings and acute postoperative liver failure. The main causes of blood loss and liver failure were discovered. The most effective means to prevent bleeding was anatomical liver resection. Lobe vascular occlusion is essential for minimal blood loss. Postoperative liver failure was strong associated with the small volume of the remnant liver and decrease in functional liver capacity. Precision selection of patients and preoperative portal vein embolisation lead to decrease the rate of liver failure (5,4%).
Modern approaches to etiology, pathogenesis and treatment of cholangitis andbiliary sepsis
Authors: Bagnenko S. F. , Shlyapnikov S. A. , Korolkov A. Yu.
Published: April 2021

To develop the optimum medical-diagnostic algorithm, allowing to lower the lethality and frequency of complications at patients with acute cholangitis and biliary sepsis. To define interrelation and to reveal distinctions between acute cholangitis and biliary sepsis. Patients with acute cholangitis and biliary sepsis of various severity and etiology; cases history. Development of the given problem will allow to lower lethality at purulent cholangitis and biliary sepsis.
Portal-systemic by-pass and the analysis of survival rate research resultsin patients with liver cirrhosis
Authors: Nazyrov F. G. , Devyatov A. V. , Ibadov R. A.
Published: April 2021

The present research is based on the analysis of 500 patients with liver cirrhosis with complicated portal hypertension. All patients were examined and operated in the department of portal hypertension and pancreatic-duodenal zone surgery of acad. V. Vakhidov Republican Specialized Surgery Centre (Tashkent) during the period of 1976 - January 2007, included. The appreciation of survival rate curve in patients with liver cirrhosis after portal-systemic shunting is given on the basis of the prognosis factors stratification, that predetermines individual approach to each patient in the choice of surgical tactics and rehabilitation actions. We have mostly studied results and efficacy of different variants of portal-systemic shunting in stratificated groups, that allowed to reveal the most favourable group of patients with LC in respect of long-term prognosis after portal-systemic shunting.
The principles of planned surgical treatment of chronic duodenal ulcer(40-years experience of Clinic named for S.P. Fyodorov)
Authors: Maystrenko N. A. , Kurygin A. A. , Kurygin Al. A.
Published: April 2021

The experience of planned treatment more than 2 000 patients with chronic duodenal ulcer makes it possible to work out the diagnostic algorithm, based on complex research of acidic stomach secretion. The principles of choosing of interference (organ-retaining, resecting or combining interference) and kind of pyloroplasty were defined. The right choice of operation of complicated duodenal ulcer secures excellent and good results for 85% patients.