bluuebunny/crossref_metadata_2025 huggingface dataset:
Determinant of customer satisfaction and loyalty in using online shopping applications
Authors: Febrianti Adjeng Mariana , Sihombing Ruth Margaret Violenta , Soetjipto Salsabila Jannatain Catur
Published: March 2022

Advances in technology and increasing business competition have caused many companies to revisit strategies in order to retain customers. Factors of satisfaction and loyalty are things that have always been the company's goal in obtaining growth. Therefore, understanding the factors that influence satisfaction and loyalty is important. This study was proposed to investigate the factors that can affect consumer satisfaction and loyalty to online application users in booking hotels. This research is a quantitative research using an explanatory research approach. The results show that the goodness of fit as a whole has met the feasibility of the model. Based on the results of the study, practically researchers can recommend the hospitality industry service platform to maintain the quality of Perceived Value and the application of Relational Quality to customers who directly come to the hotel by providing a respectful, empathetic, polite and mild attitude to help what customers need.
Análise bioeconômica da relação custo-benefício de dois protocolos de IATF utilizados em vacas zebuínas
Authors: Ferreira Jorge Luís , Rodrigues Matheus Henrique Dias , Peres Gabriel Almeida , Silva Junior Murilo Ferreira da , Vilches Júnior Mário Antônio , Santos Helcileia Dias , Ferraz José Bento Sterman
Published: March 2022

O objetivo foi avaliar a viabilidade econômica de dois experimentos realizados nos anos de 2019 e 2020, em que o primeiro experimento (P1) avaliou o efeito de dose adicional de Prostaglandina (PGF2α) e o segundo (P2) o efeito da associação de butafosfan e cianocobalamina, na taxa de prenhez de vacas de corte submetidas a inseminação artificial em tempo fixo (IATF). Para os cálculos foram considerados os custos fixos e aleatórios da prática, em reais (R$), praticados na região de Araguaína-TO em 13/05/2021. As análises financeiras foram realizadas pelo Microsoft Excel® considerando 100 vacas por tratamento de cada experimento. Foi verificado, em ambos os experimentos, que os grupos tratados tiveram maiores custos por IATF (R$: 63,98 e 67,58) em relação ao controle (R$: 60,58 e 60,58) para o P1 e P2 respectivamente, com menor custo por prenhez (R$: 95,97 e 110,26) em relação ao controle (R$: 146,58 e 133,29) resultando em melhor retorno e viabilidade econômica. Na comparação entre os protocolos (P1 e P2), P1 teve uma receita liquida de R$ 12. 853,35 e um investimento no custo de IATF de R$ 360,00. Entretanto, apesar de haver diferença financeira nessa simulação, a escolha por um ou outro protocolo deve ser tomada considerando a necessidade do rebanho, sendo que ambos os protocolos de IATF experimentais tiveram incrementos nos índices zootécnicos e resultados financeiros em comparação ao controle.
Trophic relationships in the zooplankton – gelatinous zooplankton food chain in the shelf areas of the Crimean coast of the Black Sea
Authors: Finenko G. A. , Datsyk N. A. , Anninsky B. E. , Zagorodnyaya Yu. A.
Published: March 2022

The seasonal and spatial dynamics of the key trophic characteristics were studied (food spectrum, feeding rate, and predatory impact on mesozooplankton) for populations of the jellyfish Aurelia aurita (Linnaeus, 1758) and ctenophore Mnemiopsis leidyi A. Agassiz, 1865. The investigation was carried out during four cruises of the RV “Professor Vodyanitsky” in the shelf areas of Crimean Peninsula in January to October 2016. The area was divided into inner (depth of < 50 m) and outer (51–150 m) shelves. To study the food spectrum and feeding rate of gelatinous predators, the composition of food items in the gastric cavity was analyzed under a binocular microscope. Daily ration (R, mg C·ind.−1·day−1) was calculated by the formula: R = Bz × DT−1 × 24, where Bz is zooplankton biomass in the predator gastric cavity (mg), and DT is zooplankton digestion time (h). Predatory impact of gelatinous zooplankton was estimated by the values of daily ration and mesozooplankton biomass. Zooplankton was sampled with a Juday plankton net with mouth diameter of 38 cm and mesh size of 140 µm. Vertical net hauls were performed: at the inner shelf stations, from the sea surface down to the bottom; at the outer shelf stations, down to the boundary of the hydrogen sulfide zone (δt = 16.2 conventional units according to a Sea-Bird probe). In the samples fixed with 4 % formalin solution, zooplankton abundance, its taxonomic composition, and size–age structure were quantified by standard method. In the food spectrum of the jellyfish, seasonal differences were revealed: predominance of Bivalvia veligers in winter and spring and wide species composition of Crustacea and other groups of prey in summer. The feeding rates of the studied species were similar: specific daily rations in winter, spring, and autumn did not exceed tenth of a percent of the carbon content in the body. Both species fed at a maximum rate in summer on the outer shelf: the specific rations reached 12.9 and 5.1 % C of the body for the jellyfish and ctenophore, respectively. A. aurita and M. leidyi populations consumed 0.2 to 5 % of the fodder zooplankton biomass per day; it did not result in a drastic reduction in zooplankton abundance and provided favorable feeding conditions for small planktivorous pelagic fish.
The Kaleidoscope of the Re-Presentations of Yeh/hsien (the Chinese 'Cinderella' Story)
Authors: Hu Bin
Published: March 2022

See article
Does an enquiry for socialistic changes exist in Russia?
Authors: Latov Yu. V.
Published: March 2022

Objective: to study the problem of the request for change from the viewpoint of answering the question whether there is a reactionary desire of the least modernized strata of Russians to “return to the USSR”, completely abandoning the results of the “liberal revolution” of the 1990s.

Methods: to answer the question whether there is a request for the restoration of the “Soviet socialism” in modern Russia, the materials of the all-Russian sociological surveys on a representative sample (mainly the pre-COVID survey of 2019), organized by the Institute of Sociology of the FCTAS RAS, are analyzed.

Results: it is proved that, although the popularity of more authoritarian models of the state has been growing among the Russians in the last decade, at the same time, there is an active “habituation” to private property institutions and entrepreneurship. It is concluded that at present the main object of protest sentiments is not the exploitation of labor by capital, but bureaucratic corruption. This means that the high “demand for change” is objectively connected with the mass desire not to “return to the USSR”, but to complete the dismantling of quasi-socialist (political) institutions, which began in the 1990s, but then interrupted and partially canceled.

Scientific novelty: based on the original databases of all-Russian surveys, non-trivial conclusions were drawn about the direction of the “request for change”, which controvert with the statement popular in the recent years about the request for the USSR restoration.

Practical significance: understanding the direction of the mass request for change makes it possible, without waiting for a social explosion, to plan in advance those socio-economic reforms that best meet the requirements of the Russian citizens.
Changing the paradigm of the economic science under innovative development
Authors: Petrenko T. V.
Published: March 2022

Objective: to analyze the evolution of the economic science paradigm aimed at forming a system paradigm that allows changing the style of scientific thinking, generating system solutions, in particular, in the field of transformation of labor potential relative to the demands of the digital economy.

Methods: the main method of research is the method of unity of the historical and the logical in relation to the evolution of the economic system, scientific views and principles that characterize it, as well as the principle of methodological system, which allows forming an idea of the modern economic system as a multidimensional object.

Results: the article briefly examines the evolutionary stages of the economics paradigm; it is revealed that innovative development as an objective process of changing the environment causes the modernization of key subsystems, actualizing the application of a system paradigm that allows linking and presenting an adequate interpretation of emerging facts, events, and phenomena characteristic of the modern realities of the digital economy. The need to expand the innovative potential of labor resources, observed at all stages of the reproduction process, rethinking of the role of labor and its main components puts forward the requirements for its qualitative modernization. The symbiosis of labor relations with cultural, mental and other subsystems, forming the foundations of labor consciousness and the construction of labor behavior, is considered to be an essential argument for expanding research based on a systematic approach. In this regard, scientific and applied developments aimed at the formation of mobile institutional mechanisms and structures, like institutional interaction centers focused on the development of labor potential and its harmonious improvement, enable to expand the range of the used mechanisms, setting them a vector that meets the needs of society.

Scientific novelty: based on a systematic approach, a characteristic of new institutional structures is proposed, which is related to social partnership and allows solving the problem of adaptation of labor potential to the demands of the digital economy.

Practical significance: the main provisions and conclusions of the article can be used in scientific and pedagogical activities for the formation of institutional centers of interaction.
Keynes trilemma from the viewpoint of Kleiner tetrad under the cataclysms in the society
Authors: Nikonova A. A.
Published: March 2022

Objective:to study the relations of a pair of the social system sectors in G. B. Kleyner’s tetrad, the state and the society, in different situations; to confirm the hypothesis about the difference in the society’s demands and the state’s response to environmental change, including the current crisis; to investigate the factors and possible ways to balance the interactions of the pair of sectors.

Methods:the trilemma of J. M. Keynes is studied in the application to the internal policy of the state from the standpoint of the systemic economic paradigm developed at the CEMI RAS under the supervision of G. B. Kleyner.

Results:using the tetrad model, the conditions for balanced interactions between the state and society are identified in the interpretation of the Keynes trilemma from the standpoint of welfare, freedoms, and justice. Based on the spatial-temporal analysis, Keynes’ hypothesis of the incompatibility of these goals simultaneously in the state policy is confirmed. The importance of adaptive policy is growing in a period of instability, when the structure of people’s requests is changing: the need for freedom becomes less relevant than the request for protection and quality of life.

Scientific novelty:based on the idea of the cyclical nature of the interaction between the state and society in the course of social development, patterns of sporadic occurrence and reproduction of threats to society in the absence of a reactive response to changes in the requests of agents during the exchange of resources in the macro-system are established. The key factors include the immanent basic conditions and foundations of human existence, which are the root cause of the shifting balance in the dynamics of relations (the balance of expectations of society and state policy), depending on how these needs are met. The hypothesis of a close connection of these driving factors with the critical signs of social relations in the existing model of the economy of the Russian Federation and other countries is empirically confirmed. The expansion of knowledge of the relationship between the structural and functional characteristics of the macro-system contributes to the solution of the central task of systems research.

Practical significance:the results revealed the prerequisites for the shifting of the public policy accents under the modern cataclysms. The joint use of the Keynes trilemma and Kleyner’s tetrad in such a research perspective can contribute to the formation of a synthetic approach to the analysis and modeling of mutual expectations of the key agents, the coordination of requests, and the development of divergent policies that contribute to the system harmonization.
Study Protocol: Evaluation of the ‘Flavour School’ Sensory Food Education Programme: A Cluster-Randomised Controlled Trial in UK Primary School Children, Aged 4-7 Years, to Determine Impact on Confidence and Curiosity in Tasting Vegetables and Fruit
Authors: Wilkinson Nicholas Mansel , Kannan Srimathi , Ganguri Harish B , Hetherington Marion , Evans Charlotte E.L.
Published: March 2022

Background: Many children would benefit from a diet richer in vegetables and fruit. ‘Flavour School’ is a programme of ‘sensory food education’, which aims to increase children’s confidence and curiosity in exploring foods and flavours, especially vegetables and fruit. This study will conduct a cluster-randomised controlled trial to assess the outcomes of the Flavour School programme in primary school children aged 4-7 years. Methods: 400+ children from 4+ schools will either complete the Flavour School programme (experimental group) or have no intervention with normal school teaching (control group), cluster-randomised within-schools, by school class. Baseline data collection will consist of video recorded behavioural observation during a tasting activity, and post-intervention data collection will repeat this activity after the experimental group have completed the intervention. Process measures will be assessed using a teacher engagement feedback questionnaire.Discussion: This study will provide causal data on the efficacy of a sensory food education intervention for increasing children’s confidence and curiosity in exploring foods and flavours, especially vegetables and fruit. This new knowledge will help educators and policy makers to make evidence based decisions on uptake of sensory food education.Trial registration: ISRCTN: 40249947 Date assigned 17/03/2020 Last edited 22/09/2021 Version 1.2Trial Acronym OASES (Outcomes Assessment of Sensory Education in Schools)
Glacial Debris Flow Blockage Event (2018) in the Sedongpu Basin of the Yarlung Zangbo River, China: Occurrence Factors and its Implications
Authors: baojuan huai , Ding Minghu , Xiao Cunde , Wang Junyao , Zou Xiaowei , Ai Songtao , Sun Weijun , Wang Yetang , Gao Jiajia
Published: March 2022

The cryospheric disasters, especially glacier disasters and permafrost disasters, has arose great risks to people’s lives in Tibetan Plateau under climate warming. In this paper, the glacial debris flow blockage event on October 17th, 2018, in the Sedongpu basin of the Yarlung Zangbo River is taken as an example to analyse the occurrence and development of glacier disasters in the region. It is found that the topography and climate background determine the hazard happens periodically, and they are fundamental for the weak vulnerability here. It can be reflected by the glacier dynamic simulation with Elmer/Ice model, which showed that the ice flow was extremely fast. Both heavy rain and an earthquake were triggering factors of the ice avalanche that led to the glacial debris flow. Combining analysis with documented records, we also proposed an assessment procedure for disaster-prone glaciers in this region, with key identification indices such as the type of glacier, presence of debris, slope of glacier, etc. The results indicated that the glacier disasters may seriously affected the Sichuan-Tibet Highway and local people. This synthesis study has extensive applicability and practical significance in glacier disaster prevention and mitigation under a changing climate.
Fretting Wear and Lubrication Characteristics of the Steel Ring of a Metal Belt-Type Continuously Variable Transmission
Authors: Han Ling , Zhao Wei , Cao Yue , Wang Wu Jin
Published: March 2022

The multi-field coupling mechanism of a continuously variable transmission (CVT) system has a greater impact on its overall friction loss. The friction loss of steel rings represents the internal loss of the metal belt occurring between the steel ring group and friction plate, and it is the main reason for the loss of CVT energy. This study is based on the dissipative wear model of the CVT steel ring friction pair, and it innovatively establishes a steel ring wear depth model that relates the wear depth to the macro- and micro-factors. Here, a mixed lubrication model between the friction pairs of steel rings is constructed, and the change law of oil film thickness, pressure, and temperature between the contacting bodies is obtained. On the basis of the wear depth model of the steel ring, the results of the wear depth of the steel ring are obtained via simulation using torque, speed, fretting frequency, and other operating parameters. The surface wear of the steel ring at different fretting frequencies is observed via SEM, and the simulation and test results are compared. Subsequently, the obtained results of the wear depth and oil film thickness tests are used to determine the safety margin of the application efficiency of the steel ring friction pair in the CVT working range via the interpolation processing method. According to the simulation results, the overall performance area of the safety margin of the application efficiency of the steel ring friction pair is between −1 and 1. When the torque is greater than 130 N•m, the safety margin value decreases below 0, the safety failure probability of the steel ring increases significantly, and the safety margin decreases gradually. This research can provide new insights into solving the reliability and service life of CVTs.
An Agile Model Of A Hybrid Approach To Enhance The Sustainability Of Production Management System In Industry 4.0
Authors: Tripathi Varun , Chattopadhyaya Somnath , Mukhopadhyay A.K. , Sharma Shubham , Singh Jujhar , Li Changhe , Bona Gianpaolo Di
Published: March 2022

In industry 4.0, industry individuals are emphasizing enhancing the adaptability of the production management system by a suitable approach. To accomplish it, the management individuals use various process optimization approaches includes lean manufacturing, smart manufacturing, computational intelligence, and hybrid approaches. Process optimization approaches are used to enhance production within limited constraints. The present research aims to develop an agile model using a hybrid approach for productivity enhancement in industry 4.0, this hybrid approach is the integration of lean, smart, and computational intelligence. The developed model has been validated through a case study of real production conditions in industry 4.0. The results obtained in the case study shown that the developed model can enhance production within limited constraints in industry 4.0. The authors believe that the developed model would be able to obtain productivity enhancement and providing guidelines to industry personals for improvement in the sustainability of the production management system in industry 4.0.
Superimposed Multilayer Randomly Distributed Graphene Quantum Dots and Broadband Terahertz Perfect Absorber
Authors: Deljou Seyyed Hadi , Rostami Ali , Yadipour Reza
Published: March 2022

For investigating broadband perfect absorption in the Terahertz region, a multilayer structure using superimposed Graphene quantum dots with Gaussian distribution radius is proposed. At first, a three-layer metamaterial structure, which is composed of graphene quantum dots at the top layer, dielectric material at the middle layer, and finally gold layer at the bottom is considered and investigated. The radius Gaussian distribution for three radii 400, 450, and 500 nm is considered. Results for the proposed structure including 3, 5, and 7 layers are extracted and compared. Simulation results for the 7-layer case show a broadband absorption range of (4.2THz to 8.1THz), and (4.3THz to 8.71THz) absorption value above 70%. The dielectric material is Si3N4 in the proposed structure.
Epidemiology and prognostic nomogram for esophageal cancer with liver metastasis based on the Surveillance, Epidemiology, and End Results database
Authors: Xiong Huacai , Hu Danfei , Li Mingyao , Chen Tian , Jiang Wei , Xiang Zhenfei
Published: March 2022

Background
The prognosis of esophageal cancer with liver metastasis (ECLM) is poor. This study evaluated the incidence and prognostic factors of ECLM at initial diagnosis and developed a visual nomogram to predict outcomes.
Methods
1892 eligible ECLM patients diagnosed between 2010 and 2016 were extracted from the Surveillance, Epidemiology, and End Results database (SEER). The incidence, patient overall survival (OS), and prognosis of liver metastasis were evaluated according to patient information, tumor characteristics, and therapy. Cox regression analyses were applied to evaluate prognostic factors. Based on the significant demographic and clinicopathologic factors, a novel visual nomogram was established to predict 6-month and 1-year survival for ECLM patients.
Results
The incidence of ECLM increased with age, but survival rates showed the opposite trend. From 2010 to 2016, as age increased, the incidence also increased annually, peaking at age 70 to 79 years and then decreasing. The 1-, 3-, 6-, 9- and 12-month relative cancer survival rates for ECLM patients were 84.6%, 61.3%, 44.0%, 31.4%, and 21.8%, respectively. Multivariate cox regression analysis revealed that age, gender, grade, histological type, bone metastasis, lung metastasis, brain metastasis, chemotherapy and local treatment were independent prognostic factors related to OS. Moreover, our nomogram predicted the 6-month and 1-year survival times of the population, with a C-index of 0.735 (95% CI: 0.723–0.748). The nomogram demonstrated good clinical applicability.
Conclusions
The incidence of ECLM increased with age, but survival rates showed the opposite trend. Age, gender, tumor characteristics, and therapy should be considered when predicting the prognosis of ECLM patients. The nomogram may improve clinicians’ abilities to predict individual survival and recommend treatments for ECLM patients.
Experiences and satisfaction of patients in communicating with care providers: The case of Afaan Oromoo speaker patients at Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia, 2021
Authors: Gadisa Lalisa M , Belete Yibeltal Siraneh , Demshasha Sifessa D , Nuramo Biniam Gintamo
Published: March 2022

Background
Miscommunication between patient and care provider in health service setting puts great pressure on patient satisfaction even up to life threatening especially for official language minority group. However Oromoo people is largest ethnic group in Ethiopia, there is no study conducted pertaining experiences and satisfaction of Afaan Oromoo Speaking Patients in Saint Pauls’ Hospital Millennium Medical College (SPHMMC).
Objective
Objective of this study was to explore experiences and satisfaction of Afaan Oromo speaking patients in communicating with care providers in the SPHMMC, Addis Ababa, Ethiopia, 2021.
Methods and Materials:
A phenomenological qualitative study design was employed. To select Afaan Oromoo speaking patients from each departments of SPHMMC, purposive non-probability sampling technique was used. Data collection instrument for this study was in-depth interview, observation and Focus Group Discussion. Before data analysis and interpretation, collected data was transcribed, translated, coded and managed to simplify for analysis by computer assisted software open-code version-4. The raw data was handled carefully from loosing of valuable data using computer password. After core meaning of collected data was identified and explained using method of thematic content analysis, final report/finding was written.
Result
Experiences AOSPs in communicating with care providers showed indicated, most of health care providers were not used translator and to handle the problem they use non-verbal communication. Misunderstanding of patient condition, difficulty to record accurate patient assessment, misunderstanding of Afaan Oromoo word which caused for diagnosis of seemed diagnosis were observed from patient phenomena. Six themes which were taken from patient experience indicated dissatisfaction to health service and are: Service delay, mistrust b/n care providers and patients, loss of confidence and loss of self-esteem among patients, exposing to unnecessary expenditure, and communication gap in service provision.
Conclusion & recommendation:
Experiences of AOSPs in communicating with health care providers clearly indicated their dissatisfaction to health service. Thus, SPHMMC, FMoH and RHBO have been recommended to establish LAS, professional interpreters, and to function corporately with concerned stakeholders.
Fungal Community Compositional Diversity and Fragrant Components in Medium- and High-Temperature Taorong-Type Daqu
Authors: liu yanbo , Li Xin , Li Haideng , Zhang Huimin , Shen Xiangkun , Zhang Lixin , Han Suna , Pan Chunmei
Published: March 2022

The microbial communities and fragrant components of Taorong-typed were analyzed using high-throughput sequencing (HTS) and headspace-solid phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS). At the phylum and genus levels with abundance ≥0.01% as the threshold, 3 phyla including Mucoromycota, Ascomycota, Basidiomycota were found in both medium-and high-temperature Daqu, but the abundances differed. At the genus level, 15 and 13 genera were recognized. Rhizopus (72.40%) and Thermomyces (53.32%) accounted for the largest proportions in medium- and high-temperature Daqu respectively. The medium-temperature Daqu and high-temperature Daqu were found with 40 and 29 fragrant components respectively, and contained the highest proportions of pyrazines (53.12%) and acids (32.68%) respectively. Correlation analyses between microbes and fragrant components showed Aspergillus , Hyphopichia , Trichosporon and Alternaria were all highly and positively correlated with pyrazines, but the dominant fungal communities were highly correlated only with a few single acid compounds, but not with acid compounds on the whole.
Development Of COVID-19 Severity Assessment Score In Adults Presenting With COVID-19 To The Emergency Department
Authors: Subhani Faysal , Chhotani Abdul Ahad , Waheed Shahan , Zahid Rana Osama , Azizi Kiran , Buksh Ahmed Raheem
Published: March 2022

Background: Critically-ill Covid-19 patients require extensive resources which can overburden a healthcare system already under strain due to a pandemic. A good disease severity prediction score can help allocate resources to where they are needed most. Objectives: We developed a Covid-19 Severity Assessment Score (CoSAS) to predict those patients likely to suffer from mortalities within 28 days of hospital admission. We also compared this score to Quick Sequential Organ Failure Assessment (qSOFA) in adults.Methods: CoSAS includes the following 10 components: Age, gender, Clinical Frailty Score, number of comorbidities, Ferritin level, D-dimer level, neutrophil/lymphocyte ratio, C-reactive Protein levels, systolic blood pressure and oxygen saturation. Our study was a single center study with data collected via chart review and phone calls. 309 patients were included in the study.Results: CoSAS proved to be a good score to predict Covid-19 mortality with an Area under the Curve (AUC) of 0.78. It also proved better than qSOFA (AUC of 0.70). More studies are needed to externally validate CoSAS.Conclusion: CoSAS is an accurate score to predict Covid-19 mortality in the Pakistani population.
Morphometric parameterization of flash flood risk assessment
Authors: Zelenakova Martina , Harbulakova Vlasta Ondrejka , Junakova Natalia , Hlinkova Maria , Fijko Rastislav , Abd-Elhamid Hany F.
Published: March 2022

Individual morphometric characteristics of river basins have a significant impact on its activity; affect the flow rate of water, water accumulation in the river basin, water runoff time and other attributes that affect their intensity during flash floods as well as hydrological droughts. The aim of the paper is to express the risk and impact of flash floods in the Topla River basin (Slovakia) and its sub-basins with regard to the morphometric characteristics of the area. The studied locality, especially spring of the Topla river, belongs to the area with an existing, potentially significant flood risk threatening not only important localities but also the population. The objective is to support the territories with flood mitigation measures by assessing the basin morphometric factors and to classify such areas into high, medium and low risk categories of flash floods. The model situation is developed in the ArcGIS program where the selected important morphological characteristics are assigned to all sub-basins for the Topla river together with its assessment and for each characteristic, the level of risk affecting the flash flood is determined. An important part of this study is developing a river basin susceptibility scales to flood activity in the terms of morphometric characteristics obtained from available literature, empirical relationships and human experiences The result of the sensitivity risk map of the upper part of the Topla river basin is to show, where adverse impacts on people and the surrounding environment are expected after flash floods hitting (or in the event of hydrological droughts).
Association of Periprocedural Phentolamine Infusion with Favorable Outcome in Patients with Chronic Kidney Disease and Chronic Coronary Syndrome undergoing coronary catheterization: A Prospective Randomized Controlled Study
Authors: Hamila Mohamed Abo , Ghawaby Helmy El , Zaki Mohamed , Soliman Mohamed , Gabr Khaled
Published: March 2022

BackgroundChronic kidney disease (CKD) is a major risk factor for contrast induced nephropathy acute kidney injury (CIN-AKI) in chronic coronary syndrome (CCS) patients undergoing coronary catheterization. We aimed to evaluate the efficacy of phentolamine in prevention of CIN-AKI in CKD and CCS patients undergoing percutaneous coronary catheterization for diagnostic angiography ± stenting.MethodsParticipants with CKD and CCS planned for percutaneous coronary catheterization were included, while participants with normal kidney functions were excluded. A consecutive sample of 107 participants (mean age 58.62 ± 8.96 years, 64.5% males) was selected, underwent diagnostic coronary angiography or percutaneous coronary intervention, and received either conventional CIN-AKI prevention strategy (group 1) or periprocedural phentolamine and conventional CIN-AKI prevention strategy (group 2).ResultsThe percentages of study participants who had CIN-AKI were 82.9% for group 1 and 17.1% for group 2, respectively. There were a statistically significant association between periprocedural phentolamine and prevention of CIN-AKI (OR = 0.041, 95% CI 0.0149–0.1128, P < 0.0001) and statistically significant differences between group 1 versus group 2 regarding the urine output (ml/kg) and the urine output (ml/hour) within 72 hours post procedure, the peak change in serum creatinine within 72 hours post procedure, the percentage of change relative to the baseline serum creatinine at 72 hours post procedure, and the incidence rate of major adverse cardiac and cerebrovascular events within 90 days post procedure (t(105)= -0.69, p < 0.001, t(105)= -52.46, p < 0.001, t(102) = 0.2, p 0.018, t(102) = 23.54, p < 0.001, and t(102) = 1.168, P < 0.001, respectively).ConclusionsThe incidence of CIN-AKI and the peak change in serum creatinine within 72 hours post procedure was lower in CKD patients who underwent coronary catherization and received phentolamine infusion versus intravenous saline. The significant association of phentolamine infusion with prevention of CIN-AKI highlights the potential role of phentolamine for protection of the kidney in CKD patients planned for coronary catherization.Trial Registration Number:I-111015 Date of Trial Registration: 01/06/2016
Morphology of subsurface cracks induced by Vickers indentation observed by synchrotron X-ray multiscale tomography: a case study of CaO−Al 2 O 3 −SiO 2 glass- ceramic
Authors: Okuma Gaku , Maeda Kei , Yoshida Satoshi , Takeuchi Akihisa , Wakai Fumihiro
Published: March 2022

The characterization of subsurface cracks induced by indentation is a challenge for understanding contact damage, impact, wear, erosion, and abrasion of brittle materials, because the crack pattern observable on the surface is only a part of the total crack system. Here we applied synchrotron X-ray multiscale tomography to observe the morphology of subsurface cracks produced by Vickers indentation in a novel CaO-Al2O3-SiO2 glass-ceramic with plate-like crystals forming a house-of-cards microstructure. It revealed a diverse type of crack systems around the semispherical microcrack zone beneath the indent, including a new mode II inclined lateral crack driven by the maximum shear stress. Tomography images provided knowledge on how the heterogeneous microstructure affected the toughening processes such as crack deflection, crack bridging, and microcracking.
A novel microbial-plant coupled reactor for remediating acid mine drainage and optimization of carbon sources
Authors: Lin Hai , Tang Yalu , Dong Yingbo
Published: March 2022

Acid mine drainage (AMD) is recognized as one of the most serious contamination sources in the nonferrous metal mining industry. In this study, aerobic strains VCZ02 and VCZ09, which were identified as Leclercia adecarboxylata and Klebsiella aerogenes, were screened from 11 strains of copper-zinc-resistant bacteria in the soil of the Dexing copper mine with Cu2+/Zn2+ removal rates of 46.32% / 41.03% and 57.96% / 67.05%, respectively. The composition of extracellular polymers plays an important role in the removal of heavy metals by these two strains. A mixed community consisting of VCZ02 and VCZ09 was coupled with Sagittaria sagittifolia L. to construct a microbial-plant coupled reactor to remediate AMD. Under the optimal condition of sodium acetate as carbon source, the pH of AMD increased from less than 5 to above 6.5, showing Cu2+/Zn2+ removal rates of 70-80% and above 30%, respectively. SEM–EDS results showed that VZC02 and VZC09 in the coupled reactor also helped with resisting the toxicity of heavy metals to plants by forming biofilms on the root surface and increasing the content of heavy metals on the surface of roots, thus improving the treatment effect of plants. This study provides a theoretical basis for the bioremediation of AMD and its application.
dsSynthetic: Synthetic data generation for the DataSHIELD federated analysis system
Authors: banerjee soumya , Bishop Tom RP
Published: March 2022

Objective Platforms such as DataSHIELD allow users to analyse sensitive data remotely, without having full access to the detailed data items (federated analysis). While this feature helps to overcome difficulties with data sharing, it can make it challenging to write code without full visibility of the data. One solution is to generate realistic, non-disclosive synthetic data that can be transferred to the analyst so they can perfect their code without the access limitation. When this process is complete, they can run the code on the real data. Results We have created a package in DataSHIELD ( dsSynthetic ) which allows generation of realistic synthetic data, building on existing packages. In our paper and accompanying tutorial we demonstrate how the use of synthetic data generated with our package can help DataSHIELD users with tasks such as writing analysis scripts and harmonising data to common scales and measures.
Evaluation Of Porcine Somatic And Testicular Germ Cells During Differentiation And Proliferation
Authors: Tabar Amirreza Niazi , Azizi Hossein , Roshan Mehdi Mehdinezhad , Alipour Hiva
Published: March 2022

Background: Spermatogenesis is the complex process of sperm production to transmit paternal genetic information to the subsequent generation. This process is determined by the collaboration of several germ and somatic cells, most importantly spermatogonia stem cells and Sertoli cells. To characterize germ and somatic cells in the tubule seminiferous contort in porcine and consequently has an impact on the analysis of porcine fertility.Materials and methods: Germ cells were extracted from porcine testis by enzymatic digestion before being expanded on Sandos inbred mice (SIM) embryo-derived thioguanine and ouabain-resistant fibroblasts (STO) feeder layer supplemented with FGF, EGF, and GDNF. Immunohistochemistry (IHC) and immunocytochemistry (ICC) analysis for Sox9, Vimentin, and PLZF markers were performed to examine the generated colonies of porcine testicular cells. Electron microscopy was also utilized to analyze the morphological features of the extracted porcine germ cells.Results: IHC analysis revealed that Sox9 and Vimentin were expressed in the basal compartment of the seminiferous tubules. Moreover, ICC results showed that the cells have low expression of PLZF while expressing vimentin. Heterogeneity of the in vitro cultured cells was detected via morphological analysis by the electron microscope. Conclusion: In this experimental study, we tried to reveal the exclusive information which obviously could be helpful for future success in achievement to proper therapies against infertility and sterility as an important global issue.
Genetic and Immunological Characterization of Commercial Infectious Bronchitis Virus (IBV) Vaccines Used in Korea
Authors: Park Jeongho , Jung Ji Seung , Lee Rangyeon , Yoon Sung-il , Lee Geun-Shik , Sung Hann Woo , Kwon Hyuk Moo
Published: March 2022

Infectious bronchitis virus (IBV) is the avian coronavirus that was first isolated eight decades ago and it has remained as a major contagious pathogen in the poultry industry. Although vaccination is considered the most effective preventive strategy, continuously emerging variants prohibit vaccine efficacy and cross protection. In the last two decades, because nephropathogenic strains have been prevalent, the basic structure of numerous live attenuated vaccines was based on them. For a better understanding of their antigenic and immunogenic properties, this study obtained three commercial IBV vaccines commercially available in Korea and analyzed their genetic and immunogenic features. S1 gene sequence comparison with other field strains clustered those vaccine strains into the GI-19 or GI-15 lineage. The genetic variance of vaccine strains from their parental viruses was mostly detected in HVRI. Although each vaccine strain targets both respiratory and nephrotropic IBVs, their amino acid residues were not comparable at multiple locations. Conversely, antigenic stimulation with commercial vaccines and regional IBV variants was not sufficient to modify major immune cell phenotypes. Our study suggests that vaccine selection should be carefully considered according to their structural background because genetic variance can still exist even during the manufacturing process. Further investigation of the precise immune response by each vaccine strain can improve quarantine strategies.
Rapid and Cost-Efficient Screening of Bacterial Antibiotic Susceptibility in Enterobacteriaceae – An Assay Measured by Absorbance
Authors: Axelsson Carolina , Nilson Bo , Rehnstam-Holm Ann-Sofi
Published: March 2022

Objectives: Due to the rise in antimicrobial resistance worldwide, it is becoming increasingly important to rapidly receive information on the antimicrobial susceptibility of isolated bacteria. Traditional phenotypic methods are slow but remain useful and have advantages such as low cost, as well as being easy to perform and having established analysis criteria. The objective of this study was to develop and evaluate a rapid assay that can detect antibiotic resistant bacteria phenotypically in less than 2 hours.Methods: The microplate assay is based on absorbance measurements of bacterial strains grown in liquid media with and without antibiotics (cefotaxime, meropenem and ciprofloxacin). The absorbance was measured at the beginning of the assay, and after 90 minutes of incubation. If a bacterial isolate in absence of antibiotic had more than a 50% growth increase after 90 minutes, then the susceptibility/resistance was calculated by comparing the absorbance value of the culture in the presence of antibiotic at 90 minutes with the initial absorbance value.Results: Here we show that it is possible to phenotypically screen antibiotic susceptibility of both clinical and environmental Enterobacteriaceae isolates in 90 minutes for three different antibiotics. The test showed an accuracy of 98,5%, a sensitivity of 97,4%, and a specificity of 99,3%. False susceptibility rates were 0,4% and false resistance rates were 1,2%. Conclusion: This rapid and simple absorbance test has proven suitable for screening of antibiotic susceptibility for a large number of Enterobacteriaceae strains with high accuracy and sensitivity. The method can be performed without specialized and costly materials and/or equipment, which makes it highly suitable for laboratories with limited resources and might be especially important in laboratories situated in low income countries.
Reallocating time to physical activity and sleep: Associations with Quality of Life in cancer survivors
Authors: Hidde Mary C , Lyden Kate , Henry Kim , Leach Heather J
Published: March 2022

Purpose
Quality of Life (QOL) is an important psychosocial outcome in cancer survivors (CS). Physical activity (PA), reducing sedentary time (ST), and sleep can help CS improve QOL, however these behaviors are commonly studied in isolation, despite their interdependence during the 24-hour day (i.e., time in one activity cannot increase without time decreasing in another activity). This study examined the effects of reallocating time between moderate to vigorous PA (MVPA), light PA, ST, and sleep on QOL in a mixed sample of CS.
Methods
A cross-sectional sample of CS (N = 73) diagnosed with breast (29.7%), colorectal (33.8%), or other (36.5%) cancer. MVPA, light PA, and ST were measured using the activPAL™ accelerometer, and sleep duration using the Actiwatch™ accelerometer. Both were worn for 7-days, 24-hours per day. QOL was self-reported using the Functional Assessment of Cancer Therapy-General (FACT-G) questionnaire. Isotemporal substitution models were used to reallocate 30-minutes between activities. Statistical significance was set at p < .05.
Results
Participants accumulated, M = 24.0 ± 18.9 minutes/day of MVPA, 291.7 ± 100.4 minutes/day of light PA, 593.1 ± 108.3 minutes/day of ST, and 486.6 ± 57.6 minutes/night of sleep. Isotemporal substitution effects for reallocating time between MVPA, light PA, ST and sleep were not significantly associated with QOL.
Conclusions
Findings from this study suggest that among CS who are achieving adequate levels of PA and sleep, changes in 30-minutes of these activities may not impact QOL. Future studies should aim to recruit a larger, more representative sample and explore the role of bouted activity time.
Extending the visible light absorption of NH2-UiO-66 through diazotization reaction for photocatalytic chromium (VI) reduction
Authors: Hosseini Mahdiyeh-Sadat , Abbasi Alireza , Masteri-Farahani Majid
Published: March 2022

The optical properties of NH2-UiO-66 as a visible light-active metal organic framework was further enhanced through the diazotization reaction with π-conjugated 1-naphthol reagent. Diffuse reflectance UV-Vis spectrum of diazotized MOF, named as Azo-UiO-66, exhibited a significant red shift compared to unfunctionalized NH2-UiO-66 due to the formation of diazo compound. Also, Tauc calculations indicated considerable decrease in band gap energy from 2.68 to 1.7 eV, resulted in improvement of visible light harvesting. Furthermore, other physicochemical techniques e.g. X-ray diffraction (XRD), N2 adsorption-desorption analysis, thermogravimetric analysis (TGA), energy dispersive X-ray (EDX), and CHN elemental analyses demonstrated the successful MOF diazotization with 1-naphthol and preservation of NH2-UiO-66 framework upon post modification process. The reduction of hexavalent chromium, Cr(VI), as a serious contaminant in wastewater to less toxic Cr(III) was performed over prepared photocatalyst, which demonstrated the positive role of ligand functionalization and enhancement of visible light absorption on overall photocatalytic performance of Azo-UiO-66.
Emitting Laser Array of Coherent Beam Combination System Revisited: Angular Domain Perspective and the Fractal-Based Optimization
Authors: Hou Tianyue , Chang Qi , Ma Pengfei , Long Jinhu , Su Rongtao , Ma Yanxing , Zhou Pu
Published: March 2022

Coherent beam combination (CBC) of fiber lasers holds promise for achieving high brightness laser systems, which have given rise to widespread applications such as particle accelerator, space debris removal, and industrial fabrication. The emitting laser array of CBC systems offers intriguing features in terms of agile beam steering, flexible beam shaping, and high scalability for output power and array elements. However, the theoretical model of the laser array in CBC systems is less well explored beyond the routine angular-spectrum method, where methods for optimizing the laser array configuration are more limited. Here, we explore the theory for the laser array of CBC systems in the view of angular domain. The laser array is represented by the composition of angular harmonics, the orthogonal basis over the azimuthal plane, and we elucidate the formation of mainlobe and sidelobes of the far-field interference pattern by using the orbital angular momentum spectrum analysis and azimuthal decomposition. Based on our findings, a fractal-based laser array configuration is proposed to enhance the performance of the combining system. Our work offers a deeper insight into the theoretical study and application of laser beam combination and opens opportunities for the further optimization of CBC implementations.
Dexmedetomidine attenuates ferroptosis in OGD/R H9C2 cells through regulation of miR-326-5p/LCN2 axis
Authors: Huan Sheng , Ji Yihao , Yin Guoping
Published: March 2022

Myocardial ischemia-reperfusion injury (IRI) is a common complication in cardiac surgery. A series of cascade reactions occurs during IRI, including apoptosis, necrosis, autophagy and focal death. Ferroptosis, a new way of programmed death, has been found play key role in IRI. Alleviating ferroptosis may be a potential direction of IRI treatment. In this study, we found mir-326-5p was differently expressed in four myocardial injury-related GEO database. Importantly, it could affect cell activity and regulate ferroptosis in oxygen-glucose deprivation/reperfusion (OGD/R) H9C2 cells via acting on its target gene LCN2. Interestingly, besides ferroptosis, we also found that mir-326-5p/LCN2 axis had a synergistic effect on inflammatory response and autophagy in OGD/R H9C2. Notably, we identified dexmedetomidine (DEX) as a natural agonist of mir-326-5p. In general, DEX significantly increased the expression of mir-326-5p and decreased the expression of LCN2 in OGD/R H9C2 cells, clearing cellular Fe2+ and inhibiting ferroptosis.