bluuebunny/crossref_metadata_2025 huggingface dataset:
Design of a particle damper and experimental study on vibration damping of the pipeline
Authors: Jin Gen , Zhao Zihao , Liu Binbin , Cun Wenyuan , Zhao Zhengda , Hou Minli , Chen Guo
Published: September 2021

In this work, we designed a particle damper which can be conveniently clamped on to a pipeline without affecting the existing structure, showing a promising application in vibration reduction of real aircraft. Based on the designed particle damper, the impact of particle filling rate on the vibration reduction effect, the effect of EDEM simulation on the energy consumption of particles in the vibration process of the damper, and the result of actual vibration reduction test of particle damper installed on hydraulic pipeline were investigated. It is found that the vibration of the pipeline decreases first and then increases with the increase of particle filling rate. The particle filling rate corresponding to the maximum particle energy consumption rate is consistent with that of the minimum pipeline vibration acceleration during the test, that is, from 94.9% to 97.9%. The simulation results are in good agreement with the test results. Moreover, the vibration of the hydraulic pipeline and actual aircraft pipeline are both obviously suppressed after the installation of the particle damper. These results fully demonstrate the effectiveness and practicability of the aircraft pipeline particle damper.
Ultra-precision grinding of 4H-SiC wafer by PAV/PF composite sol-gel diamond wheel
Authors: Feng Kaiping , Zhao Tianchen , Lyu Binghai , Zhou Zhaozhong
Published: September 2021

To eliminate the deep scratches on the 4H-SiC wafer surface in the grinding process, a PVA/PF composite sol-gel diamond wheel was proposed. Diamond and fillers are sheared and dispersed in the polyvinyl alcohol-phenolic resin composite sol glue, repeatedly frozen at a low temperature of −20°C to gel, then 180°C sintering to obtain the diamond wheel. Study shows that the molecular chain of polyvinyl alcohol-phenolic resin is physically cross-linked to form gel under low-temperature conditions. Tested by mechanical property testing machines, microhardness tester, and SEM. The results show that micromorphology is more uniform, the strength of the sol-gel diamond wheel is higher, the hardness uniformity is better than that of the hot pressing diamond wheel. Grinding experiments of 4H-SiC wafer were carried out with the prepared sol-gel diamond wheel. The influence of grinding speed, feed rate, and grinding depth on the surface roughness was investigated. The results showed that by using the sol-gel diamond wheel, the surface quality of 4H-SiC wafer with an average surface roughness Ra 6.42 nm was obtained under grinding wheel speed 7000 r/min, grinding feed rate 6 µm/min, and grinding depth 15 µm, the surface quality was better than that of using hot pressing diamond wheel.
Fine reconstruction of underwater images for environmental feature fusion
Authors: Xu Tao , Zhou Jiyong , Guo Wentao , Cai Lei , Ma Yukun
Published: September 2021

Complicated underwater environments, such as occlusion by foreign objects and dim light, causes serious loss of underwater targets feature. Furthermore, underwater ripples cause target deformation, which greatly increases the difficulty of feature extraction. Then, existing image reconstruction models cannot effectively achieve target reconstruction due to insufficient underwater target features, and there is a blurred texture in the reconstructed area. To solve the above problems, a fine reconstruction of underwater images with the target feature missing from the environment feature was proposed. Firstly, the salient features of underwater images are obtained in terms of positive and negative sample learning. Secondly, a layered environmental attention mechanism is proposed to retrieve the relevant local and global features in the context. Finally, a coarse-to-fine image reconstruction model, with gradient penalty constraints, is constructed to obtain the fine restoration results. Contrast experiment between the proposed algorithm and the existing image reconstruction methods has been done in stereo quantitative underwater image data set, real-world underwater image enhancement data set, and underwater image data set, clearly proving that the proposed one is more effective and superior.
Online Self-Disclosure and Social Sharing of Emotions of Women with Breast Cancer Using Instagram–Qualitative Conventional Content Analysis
Authors: Pluta Magdalena
Published: September 2021

Objectives

Women with breast cancer share their experiences and emotions about the illness on Instagram – a tool understudied when it comes to chronic illness. The paper characterizes the women's activities, and both online self-disclosure and social sharing of emotions concepts are used to help explain the women's practices.

Methods

Using qualitative conventional content analysis, four profiles of women are manually analysed, with posts as the unit of analysis ( n  =  811). Based on eleven subcategories, three broad analytical categories are introduced: self-disclosure of negative information (C1), self-disclosure of positive information (C2) and disclosure of information about other people (C3).

Results

The women post narratives about suffering resulting from cancer, and the fears they experience. Also, the posts relate to positive emotions, joyful life events, self-acceptance, or self-affirmation. While writing, the women share information about people supporting them on their way to recovery.

Discussion

The activity of women cannot be explained only by their online self-disclosure, where anonymity and lack of offline support are often emphasized. Women on Instagram are not anonymous and report on support by relatives and other people. Rimé's concept of social sharing of emotions is used to explain this phenomenon.
Women’s understanding of economic abuse in North-Western Tanzania
Authors: Serpa Pimentel Anna de , Mshana Gerry , Aloyce Diana , Peter Esther , Mchome Zaina , Malibwa Donati , Dwarumpudi Annapoorna , Kapiga Saidi , Stöckl Heidi
Published: September 2021

Introduction:

Economic abuse is a form of intimate partner violence that still lacks a clear conceptualization and therefore is often overlooked next to physical, sexual and psychological abuse. While existing categorizations recognize economic intimate partner violence as economic control, economic exploitation and employment sabotage, current measurements of economic abuse rarely capture all its forms, and the issue has not been widely explored in low- and middle-income country settings.

Methods:

We conducted in-depth interviews with 18 women in Mwanza, Tanzania to understand local perceptions and experiences of economic intimate partner violence. We used a thematic analysis approach.

Results:

Our study illustrates the complexity of economic abuse as a unique form of intimate partner violence, with women experiencing economic exploitation, employment sabotage, economic control and male economic irresponsibility. Gender norms and expectations actively played a key role in furthering abusive economic behaviour as women attempted to generate their own income and participate in financial decisions. Women’s constructs and reactions to economic abuse diverged sharply from the traditional marital expectations of dutifully accepting male control and the men being the main breadwinners in the family. Despite it being widespread, women did not find economic abuse acceptable.

Conclusion:

The results highlight that economic abuse is a complex issue and that more research on the pathways and manifestations of economic abuse globally would be beneficial. Existing measurement tools should be widened to address all dimensions of economic abuse. Addressing economic abuse will require multi-strategy interventions, working at the individual and community-level to address gender roles and masculinity norms, working with both men and women.
Comparison of intrahepatic progression patterns of hepatocellular carcinoma and colorectal liver metastases following CT-guided high dose-rate brachytherapy
Authors: Xu Han , Schmidt Robin , Hamm Charlie Alexander , Schobert Isabel Theresa , He Yubei , Böning Georg , Jonczyk Martin , Hamm Bernd , Gebauer Bernhard , Savic Lynn Jeanette
Published: September 2021

Introduction:

Given the metachronous and multifocal occurrence of hepatocellular carcinoma (HCC) and colorectal cancer metastases in the liver (CRLM), this study aimed to compare intrahepatic progression patterns after computed tomography (CT)-guided high dose-rate brachytherapy.

Patients and methods:

This retrospective analysis included 164 patients (114 HCC, 50 CRLM) treated with brachytherapy between January 2016 and January 2018. Patients received multiparametric magnetic resonance imaging (MRI) before, and about 8 weeks after brachytherapy, then every 3 months for the first, and every 6 months for the following years, until progression or death. MRI scans were assessed for local or distant intrahepatic tumor progression according to RECIST 1.1 and electronic medical records were reviewed prior to therapy. The primary endpoint was progression-free survival (PFS). Specifically, local and distant intra-hepatic PFS were assessed to determine differences between the intrahepatic progression patterns of HCC and CRLM. Secondary endpoints included the identification of predictors of PFS, time to progression (TTP), and overall survival (OS). Statistics included Kaplan–Meier analysis and univariate and multivariate Cox regression modeling.

Results:

PFS was longer in HCC [11.30 (1.33–35.37) months] than in CRLM patients [8.03 (0.73–19.80) months, p = 0.048], respectively. Specifically, local recurrence occurred later in HCC [PFS: 36.83 (1.33–40.27) months] than CRLM patients [PFS: 12.43 (0.73–21.90) months, p = 0.001]. In contrast, distant intrahepatic progression occurred earlier in HCC [PFS: 13.50 (1.33–27.80) months] than in CRLM patients [PFS: 19.80 (1.43–19.80) months, p = 0.456] but without statistical significance. Multivariate Cox regression confirmed tumor type and patient age as independent predictors for PFS.

Conclusion:

Brachytherapy proved to achieve better local tumor control and overall PFS in patients with unresectable HCC as compared to those with CRLM. However, distant progression preceded local recurrence in HCC. As a result, these findings may help design disease-specific surveillance strategies and personalized treatment planning that highlights the strengths of brachytherapy. They may also help elucidate the potential benefits of combinations with other loco-regional or systemic therapies.
Neuropeptide Y: a potential theranostic biomarker for diabetic peripheral neuropathy in patients with type-2 diabetes
Authors: Cho Noo Ree , Yu Yeuni , Oh Chang-Kyu , Ko Dai Sik , Myung Kyungjae , Lee Yoonsung , Na Hee Sam , Kim Yun Hak
Published: September 2021

Background:

Diabetic peripheral neuropathy (DPN), the most common microvascular complication of type-2 diabetes mellitus (T2DM), results in nontraumatic lower-limb amputations. When DPN is not detected early, disease progression is irreversible. Thus, biomarkers for diagnosing DPN are needed.

Methods:

We analyzed three data sets of T2DM DPN: two for mouse models (GSE70852 and GSE34889) and one for a human model (GSE24290). We found common differentially expressed genes (DEGs) in the two mouse data sets and validated them in the human data set. To identify the phenotypic function of the DEGs, we overexpressed them in zebrafish embryos. Clinical information and serum samples of T2DM patients with and without DPN were obtained from the Korea Biobank Network. To assess the plausibility of DEGs as biomarkers of DPN, we performed an enzyme-linked immunosorbent assay.

Results:

Among the DEGs, only NPY and SLPI were validated in the human data set. As npy is conserved in zebrafish, its mRNA was injected into zebrafish embryos, and it was observed that the branches of the central nervous system became thicker and the number of dendritic branches increased. Baseline characteristics between T2DM patients with and without DPN did not differ, except for the sex ratio. The mean serum NPY level was higher in T2DM patients with DPN than in those without DPN ( p = 0.0328), whereas serum SLPI levels did not differ ( p = 0.9651).

Conclusion:

In the pathogenesis of DPN, NPY may play a protective role in the peripheral nervous system and may be useful as a biomarker for detecting T2DM DPN.
An Examination of Location-Based Real-Time Dating Application Infrastructure, Profile Features, and Cybervictimization
Authors: Centelles Vanessa , Powers Ráchael A. , Moule Richard K.
Published: September 2021

The use of location-based real-time dating applications (LBRTDAs) has become commonplace among college-aged persons. With an increase in their use, these applications may serve as vectors for experiencing cybervictimization. Limited research has examined the implications that application usage has on individual experiences with cybervictimization, particularly cyberstalking, cyberharassment, image-based abuse, and identity deception. Using a sample of college students ( N = 324; 73% female), and concentrating primarily on Tinder users, this study examines the correlates of experiencing these forms of cybervictimization, concentrating on the influence that application infrastructure and profile features (e.g., Global Positioning System [GPS] functionality) have on the likelihood of cybervictimization. Results indicate inconsistent and largely insignificant effects, suggesting that opting into the use of safety features and protective measures cannot guarantee protection from application-based forms of cybervictimization. As such, policy implications and directions for future research are discussed.
Foreign Independent Directors (FID) on Chinese Firms: The Isomorphism and Conformance-Performance Conflict
Authors: Huo Chunhui , Malik Tariq H. , Wang Xiaorui
Published: September 2021

The globalization of businesses has induced the globalization of boards, and to conform to this trend in the globalization of boards, Chinese firms have had to hire foreign independent directors (FID) as a counterpart to domestic independent directors (DID). Agency theory suggests that an FID contributes to a firm’s financial performance by monitoring and advising the firm’s management. This article explores whether the FID indeed predicts the financial performance of the firm as output and input. Output financial performance refers to the return on investment, and input performance refers to the attraction of foreign investors to the firm after hiring the FID. The evidence from the top 200 Chinese firms shows that the FID does not affect the firm’s financial performance in terms of ROA (return on assets) or ROI (return on investment). However, the FID positively correlates with foreign investment, suggesting that the FID outperforms the DID in attracting foreign investment. These findings point to an alternative explanation, one of which aligns with institutional theory and isomorphism. Institutional theory explains that FID appointments serve conformance rationality more than they serve technical performance rationality. Instead of financial performance pressure, normative conformance pressure influences Chinese firms to adapt to global norms and standards. Such memetic practices support their search for international legitimacy.
A comparative study to evaluate disc degeneration on magnetic resonance imaging in patients with chronic low back pain and asymptomatic individuals
Authors: Singh Roop , Kumar Pradeep , Wadhwani Jitendra , Yadav Rohtas K , Khanna Mohit , Kaur Svareen
Published: September 2021

Objectives

The present study aimed to investigate the association of disc degeneration with low back pain and the effect of ageing on disc degeneration in low back pain versus asymptomatic individuals.

Methodology

A total of 50 patients with chronic low back pain (Group A) were compared to 25 healthy controls (Group B). Both the groups were subjected to magnetic resonance imaging of the lumbar spine and the disc degeneration was measured by the Pfirrmann grading system. The study group (Group A) was further sub-grouped into A1 (lumbar spondylosis, n = 11), A2 (mechanical back pain, n = –13) and A3 (lumbar disc herniation, n = 26).

Results

There was a statistically significant difference in degeneration at the L4-L5 ( p = 0.001) and L5-S1 disc levels ( p = 0.001) between the two groups and contiguous disc involvement was more in low back pain patients. The subgroups of group A showed no statistically significant difference. Age showed a strong positive correlation ( r > 0.5) at all the lumbar levels (except at the L5-S1, r = 0.487) with Pfirrmann grading in Group A ( p = 0.001). There was a weak positive correlation ( r = 0.414) between age and Pfirrmann grade in the controls ( p = 0.04) at the L4-L5 level only.

Conclusions

Significantly higher Pfirrmann grading on magnetic resonance imaging was found at the L4-5 and L5-S1 levels in symptomatic patients suggesting higher involvement of these levels. Progressive disc degeneration is seen with ageing but in patients with low back pain, it is significantly accelerated.
Arthroscopic Bankart Repair Versus Open Latarjet for Recurrent Shoulder Instability in Athletes
Authors: Hurley Eoghan T. , Davey Martin S. , Montgomery Connor , O’Doherty Ross , Gaafar Mohamed , Pauzenberger Leo , Mullett Hannan
Published: September 2021

Background:

In athletes with recurrent shoulder instability, arthroscopic Bankart repair (ABR) and the open Latarjet procedure (OL) are commonly indicated to restore stability and allow them to return to play (RTP).

Purpose:

To compare the outcomes of ABR and OL in athletes with recurrent shoulder instability.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

We performed a retrospective review of patients with recurrent shoulder instability who underwent ABR and OL and had a minimum 24-month follow-up. Indications for OL over ABR in this population were those considered at high risk for recurrence, including patients with glenohumeral bone loss. The patients were pair-matched in a 1:1 ratio (OL and ABR) by age, sex, sport, and level of preoperative play. We evaluated the rate, level, and timing of RTP, and the Shoulder Instability–Return to Sport after Injury (SIRSI) score between procedures. Additionally we compared the recurrence rate, visual analog scale (VAS) pain score, Subjective Shoulder Value (SSV), Rowe score, satisfaction, and whether patients would undergo the same surgery again.

Results:

Participants included 62 athletes who underwent ABR and 62 who underwent OL, with a mean follow-up of 47.7 months. There was no significant difference between ABR and OL in rate of RTP, return to preinjury level, time to return, SIRSI score, VAS score, SSV, or patient satisfaction. OL resulted in a significantly lower recurrence rate (1.6% vs 16.1% for ABR; P = .009) and a significantly higher Rowe score (mean ± SD, 90.5 ± 12.2 vs 82.2 ± 20.8 for ABR; P = .008). In collision athletes, there was no significant difference between ABR and OL regarding RTP rate (89.1% vs 94.5%; P = .489) or SIRSI score (70.4 ± 24.8 vs 73.8 ± 19.6; P = .426), but OL resulted in a lower recurrence rate (14.5% vs 1.8%; P = .031).

Conclusion:

ABR and OL resulted in excellent clinical outcomes, with high rates of RTP in athletes. However, lower recurrence rates were seen with OL.
Traumatic Leg Fractures in UEFA Football Athletes: A Matched-Cohort Analysis of Return to Play, Reinjury, Player Retention, and Performance Outcomes
Authors: Lavoie-Gagne Ophelie , Gong Matthew F. , Patel Sumit , Cohn Matthew R. , Korrapati Avinaash , Forlenza Enrico M. , Barmonyallah Moses , Parvaresh Kevin C. , Wolfson Theodore S. , Forsythe Brian
Published: September 2021

Background:

The average professional soccer team experiences 1 to 2 traumatic leg fractures per season, with unknown effects on player performance.

Purpose:

To (1) determine the rate and time to return to play (RTP) following leg fracture, (2) investigate the rate of reinjury following RTP, and (3) investigate long-term effects that lower extremity (LE) fracture may have on elite soccer player performance.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

Using publicly available records, we identified athletes sustaining a traumatic leg fracture across the 5 major European soccer leagues (English Premier League, Bundesliga, La Liga, Ligue 1, and Serie A) between 2000 and 2016. Athletes with leg fracture (femur, tibia, and/or fibula) were matched 1:2 to controls by demographic characteristics and performance metrics 1 season before the index timepoint. Investigations included the RTP rate, reinjury rate, player characteristics associated with RTP within 2 seasons, long-term player retention, performance metrics during the 4 following seasons, and subgroup analysis by player position.

Results:

A total of 112 players with LE fracture and 224 controls were identified. Players with LE fractures were absent for a mean of 157 days (range, 24-601 days) and 21 games (range, 2-68 games). The rate of RTP within 1 season was 80%, with 4% experiencing subsequent refracture. Injured players remained active in the league at a higher rate than their uninjured counterparts. As compared with controls, injured athletes played 309 fewer total minutes ( P < .05), scored 0.09 more assists per game ( P < .01) 1 season after injury, and scored 0.12 more points per game 4 seasons after injury ( P < .01). Defenders were most affected by an LE fracture, playing 5.24 fewer games ( P < .05), 603 fewer total minutes ( P < .01), and recording 0.19 more assists per 90 minutes of play as compared with controls 1 season after injury ( P < .001). Attackers and midfielders demonstrated no significant difference in metrics after RTP when compared with controls.

Conclusion:

Most players sustaining an LE fracture returned to elite soccer at the same level after a significant loss of playing time, with a 4% rate of refracture. Player retention was higher for those sustaining an LE fracture versus uninjured controls. Overall, injured players did not experience a decline in performance after recovery from an LE fracture.
Joko Widodo’s Fleeting Maritime Ambitions: An Actor-Specific Analysis of Indonesia’s Global Maritime Fulcrum
Authors: Agastia I Gusti Bagus Dharma
Published: September 2021

This study seeks to understand why President Joko ‘Jokowi’ Widodo decided to implement the Global Maritime Fulcrum (GMF) the way he did. It examines his foreign policy decisions through the actor-specific approach in foreign policy, specifically focusing on the role of the highest executive leader in making foreign policy decisions. This study seeks to understand why the GMF declined in its importance through the lens of actor-specific theory. It examines the relation between Jokowi’s psycho-milieu and his choices of foreign policy within the context of implementing the GMF vision by drawing from insights at the individual level, namely by understanding Jokowi’s political ‘self’. This study makes two observations. First, Jokowi’s inexperience in foreign policy led to a ‘hands-off’ approach in the issue areas observed. Second, his overt technocratic outlook contributed to ad-hoc decisions, which eventually impeded the development of key GMF policies. This study examines three issue areas related to the GMF: maritime policymaking, infrastructure development and diplomacy. Across these three areas, Jokowi has shown a tendency to avoid involvement in areas where he lacks expertise, which results in a haphazard implementation of the GMF.
Mission Rediscovered: Transforming Discipleship; A Commentary on the Arusha Call to Discipleship
Authors: Bevans Stephen
Published: September 2021

This review locates Kenneth Ross’s book Mission Rediscovered in the context of the history of World Mission Conferences of the World Council of Churches’ Commission on World Mission and Evangelism, the latest of which took place in Arusha, Tanzania, in March 2018. The book is a commentary on “The Arusha Call to Discipleship,” a twelve-point call to mission that was approved unanimously by the conference participants. This is an ideal book to be discussed by local congregations who want to know the latest thinking about the mission of the church.
COVID-19 and the Mission of the Church: Some Notes on the New Normal
Authors: Zandroto Iman Jaya
Published: September 2021

The COVID-19 pandemic has caused major changes in all areas of life, including the life of the church. It has caused the church to live in a new normal, challenging the church’s ability and perspective on how to carry out its mission. This article explores the mission of the church in the new normal. It provides consideration of health protocols, the use of technology, spirituality, and the church’s attitudes and actions toward the issues that are part of the new normal.
Information preferences about treatment options in diffuse cutaneous systemic sclerosis: A Delphi consensus study
Authors: Spierings Julia , Nienhuis Hilde , van Lieshout Eva , van Laar Jacob M , Pieterse Arwen H
Published: September 2021

Objectives:

The aim of this study was to identify and prioritize aspects essential for decision making in patients with diffuse cutaneous systemic sclerosis (dcSSc) and to gain insight into information preferences of treatment options which could guide development of a leaflet for patients.

Methods:

A three-round Delphi study was conducted with a panel of patients with dcSSc. The questionnaire was based on a systematic literature search regarding benefits and harms of four main treatment options in dcSSc: methotrexate, mycophenolate mofetil, cyclophosphamide pulses and stem cell transplantation. Patients were asked to identify information that is essential for making a treatment decision. After the third round, a live, online discussion was held in order to reach consensus on these items and to discuss the content and design of the leaflet. Consensus was defined as ⩾75% agreement among panel members.

Results:

Of the 36 patients invited, 78% (n = 28) participated in one or more rounds, 67% (n = 24) completed the first, 69% (n = 25) the second and 75% (n = 27) the third round. In the last round, median age of participants was 51 years (interquartile range, 18) and median disease duration 4 years (interquartile range, 5); 52% were female. Patients had been treated with mycophenolate mofetil (67%), methotrexate (44%), cyclophosphamide (41%), autologous stem cell transplantation (26%), rituximab (4%) or were treatment-naïve (7%). Eight patients joined the live panel discussion. The panel reached consensus on seven benefits (prolonged progression-free survival, improved quality of life, improved daily functioning, improved pulmonary function, improved skin thickness, improved mobility and reduced fatigue) and four harms (treatment-related mortality, infections, cardiac damage, increased risk of cancer) as essential information for decision making. Also a design of a leaflet was made.

Conclusion:

This study identified information about treatment options in dcSSc that should be addressed with patients. Our results can be used to develop effective patient information.
Latent Medical Conditions of Drivers Involved in Road Traffic Collisions in Ghana: Implication from Autopsy Findings
Authors: Ossei Paul Poku Sampene , Agyeman-Duah Eric , Ayibor William Gilbert , Niako Nicholas , Safo Kwakye Foster
Published: September 2021

Background:

Unlike some neighboring countries like Nigeria, few studies on actual causes, impact and the prevention of road traffic collisions have been carried out in Ghana. There is the need for further research and this study sought to link injuries that caused the death of drivers involved in vehicular collisions to the latent possible contributing diseases and medical conditions in these drivers and how these conditions predispose them to the collisions.

Methods:

This is a retrospective study that used the forensic autopsy records of driver fatalities and various injuries and medical conditions of drivers involved in road traffic collisions. Information on all drivers was retrieved from archives at the Komfo Anokye Teaching Hospital’ Pathology Unit. Demographics and cause of death were used in selecting the cases, including all driver-related road traffic collisions from 2009 to 2014.

Results:

A total of 1842 road traffic collisions were recorded with 127 of them being driver related. There were 31 cases (24.4%) in 2014; the highest cases recorded for this study, with the least recorded in 2009 with only 12 cases (9.4%). There were 121 (95.3%) male drivers and 6 female drivers (4.7%). Most of the male drivers were between the ages of 30 and 39 with 39 cases, while that of females was between 40 and 49 years with 6 cases. There was no significant statistical correlation between age and sex ( P = .124). No statistical correlation also existed between sex and year ( P = .331). Pathologies of all body systems were established. Cardiovascular diseases were the most prevalent systemic medical condition seen in the drivers with 44.1%.

Conclusion:

The study established that the drivers had various latent medical conditions and all these could lead to possible incapacitation, affecting driver judgment, leading to collisions on the road. The National Road Safety Commission (NRSC) should request medical screening before issuing driver licenses.
Primary mediastinal large B-cell lymphoma
Authors: Savage Kerry J.
Published: September 2021

Primary mediastinal large B-cell lymphoma (PMBCL) is a separate entity in the World Health Organization’s classification, based on clinicopathologic features and a distinct molecular signature that overlaps with nodular sclerosis classic Hodgkin lymphoma (cHL). Molecular classifiers can distinguish PMBCL from diffuse large B-cell lymphoma (DLBCL) using ribonucleic acid derived from paraffin-embedded tissue and are integral to future studies. However, given that ∼5% of DLBCL can have a molecular PMBCL phenotype in the absence of mediastinal involvement, clinical information remains critical for diagnosis. Studies during the past 10 to 20 years have elucidated the biologic hallmarks of PMBCL that are reminiscent of cHL, including the importance of the JAK-STAT and NF-κB signaling pathways, as well as an immune evasion phenotype through multiple converging genetic aberrations. The outcome of PMBCL has improved in the modern rituximab era; however, whether there is a single standard treatment for all patients and when to integrate radiotherapy remains controversial. Regardless of the frontline therapy, refractory disease can occur in up to 10% of patients and correlates with poor outcome. With emerging data supporting the high efficacy of PD1 inhibitors in PMBCL, studies are underway that integrate them into the up-front setting.
Micro-scale Realization of Compliant Mechanisms: Manufacturing Processes and Constituent Materials—A Review
Authors: Wang Minchang , Ge Daohan , Zhang Liqiang , Herder Just L.
Published: September 2021

Compliant micromechanisms (CMMs) acquire mobility from the deflection of elastic members and have been proven to be robust by millions of silicon MEMS devices. However, the limited deflection of silicon impedes the realization of more sophisticated CMMs, which often require larger deflections. Recently, some novel manufacturing processes have emerged but are not well known by the community. In this paper, the realization of CMMs is reviewed, aiming to provide help to mechanical designers to quickly find the proper realization method for their CMM designs. To this end, the literature surveyed was classified and statistically analyzed, and representative processes were summarized individually to reflect the state of the art of CMM manufacturing. Furthermore, the features of each process were collected into tables to facilitate the reference of readers, and the guidelines for process selection were discussed. The review results indicate that, even though the silicon process remains dominant, great progress has been made in the development of polymer-related and composite-related processes, such as micromolding, SU-8 process, laser ablation, 3D printing, and the CNT frameworking. These processes result in constituent materials with a lower Young’s modulus and larger maximum allowable strain than silicon, and therefore allow larger deflection. The geometrical capabilities (e.g., aspect ratio) of the realization methods should also be considered, because different types of CMMs have different requirements. We conclude that the SU-8 process, 3D printing, and carbon nanotube frameworking will play more important roles in the future owing to their excellent comprehensive capabilities.
Strategies and Structure Feature of the Aboveground and Belowground Microbial Community Respond to Drought in Wild Rice (Oryza longistaminata)
Authors: Xie Jian , Wang Xiaoqing , Xu Jiawang , Xie Hongwei , Cai Yaohui , Liu Yizheng , Ding Xia
Published: September 2021

Background

Drought is global environmental stress that limits crop yields. Plant-associated microbiomes play a crucial role in determining plant fitness in response to drought, yet the fundamental mechanisms for maintaining microbial community stability under drought disturbances in wild rice are poorly understood. We make explicit comparisons of leaf, stem, root and rhizosphere microbiomes from the drought-tolerant wild rice (Oryza longistaminata) in response to drought stress.

Results

We find that the response of the wild rice microbiome to drought was divided into aboveground–underground patterns. Drought reduced the leaf and stem microbial community diversity and networks stability, but not that of the roots and rhizospheres. Contrary to the aboveground microbial networks, the drought-negative response taxa exhibited much closer interconnections than the drought-positive response taxa and were the dominant network hubs of belowground co-occurrence networks, which may contribute to the stability of the belowground network. Notably, drought induces enrichment of Actinobacteria in belowground compartments, but not the aboveground compartment. Additionally, the rhizosphere microbiome exhibited a higher proportion of generalists and broader habitat niche breadth than the microbiome at other compartments, and drought enhanced the proportion of specialists in all compartments. Null model analysis revealed that both the aboveground and belowground-community were governed primarily by the stochastic assembly process, moreover, drought decreased ‘dispersal limitation’, and enhanced ‘drift’.

Conclusions

Our results provide new insight into the different strategies and assembly mechanisms of the above and belowground microbial community in response to drought, including enrichment of taxonomic groups, and highlight the important role of the stochastic assembly process in shaping microbial community under drought stress.
An iteration model for identifying essential proteins by combining comprehensive PPI network with biological information
Authors: Li Shiyuan , Zhang Zhen , Li Xueyong , Tan Yihong , Wang Lei , Chen Zhiping
Published: September 2021

Background

Essential proteins have great impacts on cell survival and development, and played important roles in disease analysis and new drug design. However, since it is inefficient and costly to identify essential proteins by using biological experiments, then there is an urgent need for automated and accurate detection methods. In recent years, the recognition of essential proteins in protein interaction networks (PPI) has become a research hotspot, and many computational models for predicting essential proteins have been proposed successively.

Results

In order to achieve higher prediction performance, in this paper, a new prediction model called TGSO is proposed. In TGSO, a protein aggregation degree network is constructed first by adopting the node density measurement method for complex networks. And simultaneously, a protein co-expression interactive network is constructed by combining the gene expression information with the network connectivity, and a protein co-localization interaction network is constructed based on the subcellular localization data. And then, through integrating these three kinds of newly constructed networks, a comprehensive protein–protein interaction network will be obtained. Finally, based on the homology information, scores can be calculated out iteratively for different proteins, which can be utilized to estimate the importance of proteins effectively. Moreover, in order to evaluate the identification performance of TGSO, we have compared TGSO with 13 different latest competitive methods based on three kinds of yeast databases. And experimental results show that TGSO can achieve identification accuracies of 94%, 82% and 72% out of the top 1%, 5% and 10% candidate proteins respectively, which are to some degree superior to these state-of-the-art competitive models.

Conclusions

We constructed a comprehensive interactive network based on multi-source data to reduce the noise and errors in the initial PPI, and combined with iterative methods to improve the accuracy of necessary protein prediction, and means that TGSO may be conducive to the future development of essential protein recognition as well.
DI2: prior-free and multi-item discretization of biological data and its applications
Authors: Alexandre Leonardo , Costa Rafael S. , Henriques Rui
Published: September 2021

Background

A considerable number of data mining approaches for biomedical data analysis, including state-of-the-art associative models, require a form of data discretization. Although diverse discretization approaches have been proposed, they generally work under a strict set of statistical assumptions which are arguably insufficient to handle the diversity and heterogeneity of clinical and molecular variables within a given dataset. In addition, although an increasing number of symbolic approaches in bioinformatics are able to assign multiple items to values occurring near discretization boundaries for superior robustness, there are no reference principles on how to perform multi-item discretizations.

Results

In this study, an unsupervised discretization method, DI2, for variables with arbitrarily skewed distributions is proposed. Statistical tests applied to assess differences in performance confirm that DI2 generally outperforms well-established discretizations methods with statistical significance. Within classification tasks, DI2 displays either competitive or superior levels of predictive accuracy, particularly delineate for classifiers able to accommodate border values.

Conclusions

This work proposes a new unsupervised method for data discretization, DI2, that takes into account the underlying data regularities, the presence of outlier values disrupting expected regularities, as well as the relevance of border values. DI2 is available at https://github.com/JupitersMight/DI2
RPocket: an intuitive database of RNA pocket topology information with RNA-ligand data resources
Authors: Zhou Ting , Wang Huiwen , Zeng Chen , Zhao Yunjie
Published: September 2021

Background

RNA regulates a variety of biological functions by interacting with other molecules. The ligand often binds in the RNA pocket to trigger structural changes or functions. Thus, it is essential to explore and visualize the RNA pocket to elucidate the structural and recognition mechanism for the RNA-ligand complex formation.

Results

In this work, we developed one user-friendly bioinformatics tool, RPocket. This database provides geometrical size, centroid, shape, secondary structure element for RNA pocket, RNA-ligand interaction information, and functional sites. We extracted 240 RNA pockets from 94 non-redundant RNA-ligand complex structures. We developed RPDescriptor to calculate the pocket geometrical property quantitatively. The geometrical information was then subjected to RNA-ligand binding analysis by incorporating the sequence, secondary structure, and geometrical combinations. This new approach takes advantage of both the atom-level precision of the structure and the nucleotide-level tertiary interactions. The results show that the higher-level topological pattern indeed improves the tertiary structure prediction. We also proposed a potential mechanism for RNA-ligand complex formation. The electrostatic interactions are responsible for long-range recognition, while the Van der Waals and hydrophobic contacts for short-range binding and optimization. These interaction pairs can be considered as distance constraints to guide complex structural modeling and drug design.

Conclusion

RPocket database would facilitate RNA-ligand engineering to regulate the complex formation for biological or medical applications. RPocket is available at http://zhaoserver.com.cn/RPocket/RPocket.html.
An integrated strategy for target SSR genotyping with toleration of nucleotide variations in the SSRs and flanking regions
Authors: Huo Yongxue , Zhao Yikun , Xu Liwen , Yi Hongmei , Zhang Yunlong , Jia Xianqing , Zhao Han , Zhao Jiuran , Wang Fengge
Published: September 2021

Background

With the broad application of high-throughput sequencing and its reduced cost, simple sequence repeat (SSR) genotyping by sequencing (SSR-GBS) has been widely used for interpreting genetic data across different fields, including population genetic diversity and structure analysis, the construction of genetic maps, and the investigation of intraspecies relationships. The development of accurate and efficient typing strategies for SSR-GBS is urgently needed and several tools have been published. However, to date, no suitable accurate genotyping method can tolerate single nucleotide variations (SNVs) in SSRs and flanking regions. These SNVs may be caused by PCR and sequencing errors or SNPs among varieties, and they directly affect sequence alignment and genotyping accuracy.

Results

Here, we report a new integrated strategy named the accurate microsatellite genotyping tool based on targeted sequencing (AMGT-TS) and provide a user-friendly web-based platform and command-line version of AMGT-TS. To handle SNVs in the SSRs or flanking regions, we developed a broad matching algorithm (BMA) that can quickly and accurately achieve SSR typing for ultradeep coverage and high-throughput analysis of loci with SNVs compatibility and grouping of typed reads for further in-depth information mining. To evaluate this tool, we tested 21 randomly sampled loci in eight maize varieties, accompanied by experimental validation on actual and simulated sequencing data. Our evaluation showed that, compared to other tools, AMGT-TS presented extremely accurate typing results with single base resolution for both homozygous and heterozygous samples.

Conclusion

This integrated strategy can achieve accurate SSR genotyping based on targeted sequencing, and it can tolerate single nucleotide variations in the SSRs and flanking regions. This method can be readily applied to divergent sequencing platforms and species and has excellent application prospects in genetic and population biology research. The web-based platform and command-line version of AMGT-TS are available at https://amgt-ts.plantdna.site:8445 and https://github.com/plantdna/amgt-ts, respectively.
How the seed coat affects the mother’s oviposition preference and larval performance in the bean beetle (Acanthoscelides obtectus, Coleoptera: Chrysomelidae, Bruchinae) in leguminous species
Authors: Szentesi Árpád
Published: September 2021

Background

The host specificity and host range of the dry bean beetle, Acanthoscelides obtectus (Coleoptera: Chrysomelidae, Bruchinae), a seed predator of beans, is poorly known. In addition, the female oviposition preference and larval performance relationship is complicated by the respective importance of seed coat and cotyledon, because, paradoxically, females lay eggs on the basis of stimuli of the seed coat alone, without directly being able to assess the quality of the cotyledon’s suitability for larval development. Conversely, the thickness of seed coat may prevent first instar larvae from entering the seeds, even if cotyledons are suitable for development.

Methods

The seeds of 62 leguminous species and 75 cultivars and accessions occurring in Hungary were evaluated for preference-performance relations. The preference of female bean beetles for seeds was measured in no-choice egg-laying tests. The ability of first instar larvae to overcome the seed coat as a physical barrier was tested with intact seed coat, while pre-drilled seed coats allowed the larvae to assess the suitability of cotyledon for development. The number of emerging adults was recorded. The thickness of seed coats and the weight of seeds were measured. Nonparametric tests and logistic regression were used for the statistical analyses of data and effect sizes were also calculated.

Results

Seeds of 18 leguminous species (35% of them Lathyrus) supported larval development to adults if the seed coat was pre-drilled; however, only nine leguminous species supported development to adults if the seed coat was intact. Seed coat thickness beyond a critical threshold of 0.1 mm strongly influenced survival of first instar larvae. There was no overall positive correlation between oviposition preference and larval performance, except for 16 so-called acceptable non-hosts (Kendall’s τ = 0.3088). A. obtectus females also showed an ovipositional hierarchy of legume species even in no-choice tests.

Conclusions

The results suggest that whereas the use of some acceptable non-host species by the A. obtectus is possible in seed stores, the same is unlikely under outdoor conditions, where the recognition of a diverse set of seed pod-related compounds would be necessary to induce egg-laying.
Association between the modified Nutrition Risk in Critically Ill (mNUTRIC) score and clinical outcomes in the intensive care unit: a secondary analysis of a large prospective observational study
Authors: Wang Na , Wang Mei-Ping , Jiang Li , Du Bin , Zhu Bo , Xi Xiu-Ming
Published: September 2021

Background

Malnutrition in intensive care unit (ICU) patients is associated with adverse clinical outcomes. The modified nutrition risk in the critically ill score (mNUTRIC) was proposed as an appropriate nutritional assessment tool in critically ill patients, but it has not been fully demonstrated and widely used. Our study was conducted to identify the nutritional risk in ICU patients using the mNUTRIC score and explore the relationship between 28-day mortality and high mNUTRIC scores.

Methods

This study is a secondary analysis, the data were extracted from The Beijing Acute Kidney Injury Trial (BAKIT). In total, 9049 patients were admitted consecutively, and 3107 patients with complete clinical data were included in this study. We divided the study population into high nutritional risk (mNUTRIC score ≥ 5 points) and low nutritional risk (mNUTRIC score < 5 points) groups. The predictive capacity of the mNUTRIC score was studied by receiver operating characteristic (ROC) curve analysis, appropriate cut-off was identified by highest combined sensitivity and specificity using Youden’s index. The significance level was set at 5%.

Results

Among the 3107 patients, the 28-day mortality rate was 17.4% (540 patients died). Nearly 28.2% of patients admitted to the ICU were at risk of malnutrition, high nutritional risk patients were older (P < 0.001), with higher illness severity scores than low nutritional risk patients. Multivariate analysis revealed that the mNUTRIC score was an independent risk factor for 28-day mortality and mortality increased with increasing scores (p = 0.000). The calculated area under curve (AUC) for the mNUTRIC score was 0.763 (CI 0.740–0.786). According to Youden’s index, we found a suitable cut-off > 4 for the mNUTRIC score to predict the 28-day mortality.

Conclusions

Patients admitted to the ICU were at high risk of malnutrition, and a high mNUTRIC score was associated with increased ICU length of stay and higher mortality. More large prospective studies are needed to demonstrate the validity of this score.

Trial registration

This study was registered at www.chictr.org.cn (registration number Chi
CTR-ONC-11001875). Registered on 14 December 2011.