bluuebunny/crossref_metadata_2025 huggingface dataset:
Anticholinergic Load Is Associated with Swallowing Dysfunction in Convalescent Older Patients after a Stroke
Authors: Kose Eiji , Hirai Toshiyuki , Seki Toshiichi , Okudaira Michiyo , Yasuno Nobuhiro
Published: May 2022

This study aimed to establish whether anticholinergic load affects the swallowing function of geriatric stroke patients in convalescent stages, as no proven association between the anticholinergic load-based Anticholinergic Risk Scale and the swallowing dysfunction in Japanese patients was known. A retrospective cohort study was conducted on hospitalized older patients undergoing rehabilitation after stroke. The study outcomes included evaluating the patients at hospital discharge using the Functional Oral Intake Scale. To evaluate the effects of an increased anticholinergic load, we used a multivariate analysis to examine whether the change in the Anticholinergic Risk Scale during hospitalization was associated with the outcome. Of 542 enrolled patients, 345 (63.7%) presented with cerebral infarction, 148 (27.3%) with intracerebral hemorrhage, and 49 (9%) with subarachnoid hemorrhage. The change in the Anticholinergic Risk Scale was independently associated with the Functional Oral Intake Scale (β = −0.118, p = 0.0164) at discharge. Among anticholinergics, the use of chlorpromazine, hydroxyzine, haloperidol, metoclopramide, risperidone, etc., increased significantly from admission to discharge. An increased anticholinergic load was associated with swallowing dysfunction in older patients undergoing stroke rehabilitation.
Effects of Taro (Colocasia esculenta) Water-Soluble Non-Starch Polysaccharide, Lactobacillus acidophilus, Bifidobacterium breve, Bifidobacterium infantis, and Their Synbiotic Mixtures on Pro-Inflammatory Cytokine Interleukin-8 Production
Authors: Anwar Mylene , Mros Sonya , McConnell Michelle , Bekhit Alaa El-Din A.
Published: May 2022

In the past decades, the regulation of pro-inflammatory cytokine production, including interleukin-8 (IL-8), has been the goal of many targeted therapeutic interventions for Necrotising enterocolitis (NEC), a gastrointestinal disease commonly associated with a very low birth weight in preterm infants. In this study, the ability to regulate the production of IL-8 of the water-soluble non-starch polysaccharide (WS-NSP) from taro corm (Tc-WS-NSP) extracted using a conventional (CE) or improved conventional (ICE) extraction method, of the probiotics Lactobacillus acidophilus, Bifidobacterium breve, and Bifidobacterium infantis, and their synbiotic mixtures were evaluated. The TNF-α stimulated HT-29 cells were incubated with undigested or digested Tc-WS-NSPs (CE or ICE), probiotics, and their synbiotic mixtures with Klebsiella oxytoca, an NEC-positive-associated pathogen. Overall, the synbiotic mixtures of digested Tc-WS-NSP-ICE and high bacterial concentrations of L. acidophilus (5.57 × 109), B. breve (2.7 × 108 CFU/mL), and B. infantis (1.53 × 108) demonstrated higher (42.0%, 45.0%, 43.1%, respectively) ability to downregulate IL-8 compared to the sole use of Tc-WS-NSPs (24.5%), or the probiotics L. acidophilus (32.3%), B. breve (37.8%), or B. infantis (33.1%). The ability demonstrated by the Tc-WS-NSPs, the probiotics, and their synbiotics mixtures to downregulate IL-8 production in the presence of an NEC-positive-associated pathogen may be useful in the development of novel prophylactic agents against NEC.
In-Hospital Patient Education Markedly Reduces Alcohol Consumption after Alcohol-Induced Acute Pancreatitis
Authors: Nagy Rita , Ocskay Klementina , Váradi Alex , Papp Mária , Vitális Zsuzsanna , Izbéki Ferenc , Boros Eszter , Gajdán László , Szentesi Andrea , Erőss Bálint , Hegyi Péter Jenő , Vincze Áron , Bajor Judit , Sarlos Patricia , Mikó Alexandra , Márta Katalin , Pécsi Dániel , Párniczky Andrea , Hegyi Péter
Published: May 2022

Although excessive alcohol consumption is by far the most frequent cause of recurrent acute pancreatitis (AP) cases, specific therapy is still not well established to prevent recurrence. Generally, psychological therapy (e.g., brief intervention (BI)) is the cornerstone of cessation programs; however, it is not yet widely used in everyday practice. We conducted a post-hoc analysis of a prospectively collected database. Patients suffering from alcohol-induced AP between 2016 and 2021 received 30 min BI by a physician. Patient-reported alcohol consumption, serum gamma-glutamyl-transferase (GGT) level, and mean corpuscular volume (MCV) of red blood cells were collected on admission and at the 1-month follow-up visit to monitor patients’ drinking habits. Ninety-nine patients with alcohol-induced AP were enrolled in the study (mean age: 50 ± 11, 89% male). A significant decrease was detected both in mean GGT value (294 ± 251 U/L vs. 103 ± 113 U/L, p < 0.001) and in MCV level (93.7 ± 5.3 U/L vs. 92.1 ± 5.1 U/L, p < 0.001) in patients with elevated on-admission GGT levels. Notably, 79% of the patients (78/99) reported alcohol abstinence at the 1-month control visit. Brief intervention is an effective tool to reduce alcohol consumption and to prevent recurrent AP. Longitudinal randomized clinical studies are needed to identify the adequate structure and frequency of BIs in alcohol-induced AP.
The Role of Dietary Intake in Type 2 Diabetes Mellitus: Importance of Macro and Micronutrients in Glucose Homeostasis
Authors: Kheriji Nadia , Boukhalfa Wided , Mahjoub Faten , Hechmi Meriem , Dakhlaoui Thouraya , Mrad Mehdi , Hadj Salah Bahlous Afef , Ben Amor Nadia , Jamoussi Henda , Kefi Rym
Published: May 2022

The prevalence of Type 2 diabetes (T2D) is increasing worldwide. Genetics and lifestyle, especially diet, are contributing factors. Analyses of macro- and micronutrient intake across global populations may help to explain their impact on glucose homeostasis and disease development. To this end, 420 Tunisians were enrolled in a prospective cross-sectional study of daily food consumption. Various data were collected and blood samples were drawn for biochemical assay. A 24-h recall questionnaire was obtained from participants to evaluate dietary intake. Statistical analyses were conducted using Nutrilog and R software. Biochemical analyses stratified the studied population (n = 371) into three groups: diabetics (n = 106), prediabetics (n = 192) and controls (n = 73); 49 subjects were excluded. Our results showed that Tunisians had hypercaloric diets high in carbohydrates and fat with variability in the levels of some vitamins and minerals, including riboflavin and niacin, that were statistically different among groups. The lower intake of vitamin D was associated with a greater risk of T2D. Higher vitamin A and sodium intake were associated with poor glucose homeostasis, although protein intake may improve it. In perspective, nutrigenomic studies can provide insight into problematic diets and poor eating habits and offer opportunities to analyze the effects of behavioral changes that can mitigate T2D development and progression.
Formulation, Characterization and Optimization of β–Glucan and Pomegranate Juice Based Films for Its Potential in Diabetes
Authors: Avramia Ionut , Amariei Sonia
Published: May 2022

The aim of this study was to develop films based on β–glucans in association with pomegranate juice for its potential in metabolic disorders such as diabetes due to plenty of bioactive compounds from the film composition. Initially, a Box-Behnken design was generated by varying the level of β–glucan content (0.5, 1, 1.5 g), sodium alginate (0.2, 0.4, 0.6 g) and pomegranate juice (10, 20, 30 mL) for development of films. Subsequently, glycerin was added as 25% of the total dry matter. The optimization of the films prepared by the solvent casting method was conducted based on the different responses such as: water vapor transmission rate (WVTR), water vapor permeability (WVP), thickness, density, moisture content, solubility, film opacity and color. The water activity profile and FT–IR analysis were performed in all tests. The model was used to determine the optimal experimental values considering that the optimal film will make a sustained contribution to diabetes. The optimal values of the film sample made of β–glucans, sodium alginate, pomegranate juice and glycerin make it befitting for packaging dry powdered pharmaceuticals. Finally, antimicrobial activity against Gram-negative and Gram-positive bacteria, UV barrier properties and microcrack and pore detections through SEM were also investigated for the optimal film sample.
The Effects of “Diet–Smoking–Gender” Three-Way Interactions on Cognitive Impairment among Chinese Older Adults
Authors: Chen Huashuai , Zhang Xuxi , Feng Qiushi , Zeng Yi
Published: May 2022

Investigations on gender variations in the risk factors of cognitive impairment are required to promote future precision medicine among older adults, as well as to contribute to a better understanding of the “male–female health-survival paradox”. With this study, we aimed to investigate the effects of “diet–smoking–gender” three-way interactions on cognitive impairments among Chinese older adults. We conducted a 16-year prospective cohort study among 15,953, 15,555, 16,849, 9716, 7116, and 13,165 older adults from the 2002, 2005, 2008–2009, 2011–2012, 2014, and 2017–2018 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), respectively. Cognitive impairment was measured by the Mini-Mental State Examination (MMSE). The dietary diversity score (DDS) was calculated using the CLHLS food frequency questionnaire. Generalized estimating equations (GEE) were used to assess the “diet–smoking–gender” three-way interaction effects on cognitive impairment across the six waves of CLHLS. We found that higher dietary diversity was associated with lower probability of cognitive impairment among older adults (OR = 0.92; 95%CI = 0.90, 0.98). However, smoking behavior may negatively influence the protective effect of higher dietary diversity on cognitive function among females (OR = 1.26; 95%CI = 1.07, 1.49). Our findings imply that we should take gender differences and lifestyle behaviors into consideration in implementing dietary interventions to improve cognitive function among older adults.
Experimental Bovine Spongiform Encephalopathy in Squirrel Monkeys: The Same Complex Proteinopathy Appearing after Very Different Incubation Times
Authors: Piccardo Pedro , Cervenak Juraj , Goldmann Wilfred , Stewart Paula , Pomeroy Kitty , Gregori Luisa , Yakovleva Oksana , Asher David
Published: May 2022

Incubation periods in humans infected with transmissible spongiform encephalopathy (TSE) agents can exceed 50 years. In humans infected with bovine spongiform encephalopathy (BSE) agents, the effects of a “species barrier,” often observed when TSE infections are transmitted from one species to another, would be expected to increase incubation periods compared with transmissions of same infectious agents within the same species. As part of a long-term study investigating the susceptibility to BSE of cell cultures used to produce vaccines, we inoculated squirrel monkeys (Saimiri sp., here designated SQ) with serial dilutions of a bovine brain suspension containing the BSE agent and monitored them for as long as ten years. Previously, we showed that SQ infected with the original “classical” BSE agent (SQ-BSE) developed a neurological disease resembling that seen in humans with variant CJD (vCJD). Here, we report the final characterization of the SQ-BSE model. We observed an unexpectedly marked difference in incubation times between two animals inoculated with the same dilution and volume of the same C-BSE bovine brain extract on the same day. SQ-BSE developed, in addition to spongiform changes and astrogliosis typical of TSEs, a complex proteinopathy with severe accumulations of protease-resistant prion protein (PrPTSE), hyperphosphorylated tau (p-tau), ubiquitin, and α-synuclein, but without any amyloid plaques or β-amyloid protein (Aβ) typical of Alzheimer’s disease. These results suggest that PrPTSE enhanced the accumulation of several key proteins characteristically seen in human neurodegenerative diseases. The marked variation in incubation periods in the same experimental TSE should be taken into account when modeling the epidemiology of human TSEs.
Pericardial Effusion Due to Trichosporon japonicum: A Case Report and Review of the Literature
Authors: Menu Estelle , Kabtani Jihane , Roubin Johanna , Ranque Stéphane , L’Ollivier Coralie
Published: May 2022

Invasive infections due to Trichosporon spp. are life-threatening opportunistic fungal infections that may affect a wide array of organs. Here, we described a case of pericardial effusion due to Trichosporon japonicum in a 42-year-old female after a heart transplantation. T. japonicum was isolated from the pericardial fluid, pericardial drain hole and the swab of the sternal surgery scar wound. The late mycological diagnosis due to blood culture negative, the ineffective control of pulmonary bacterial infection and the late start antifungal therapy were the contributing factors in the patient’s death.
Nitro-Group-Containing Thiopeptide Derivatives as Promising Agents to Target Clostridioides difficile
Authors: Kim Dahyun , Kim Young-Rok , Hwang Hee-Jong , Ciufolini Marco A. , Lee Jusuk , Lee Hakyeong , Clovis Shyaka , Jung Sungji , Oh Sang-Hun , Son Young-Jin , Kwak Jin-Hwan
Published: May 2022

The US Centers for Disease Control and Prevention (CDC) lists Clostridioides difficile as an urgent bacterial threat. Yet, only two drugs, vancomycin and fidaxomicin, are approved by the FDA for the treatment of C. difficile infections as of this writing, while the global pipeline of new drugs is sparse at best. Thus, there is a clear and urgent need for new antibiotics against that organism. Herein, we disclose that AJ-024, a nitroimidazole derivative of a 26-membered thiopeptide, is a promising anti-C. difficile lead compound. Despite their unique mode of action, thiopeptides remain largely unexploited as anti-infective agents. AJ-024 combines potent in vitro activity against various strains of C. difficile with a noteworthy safety profile and desirable pharmacokinetic properties. Its time-kill kinetics against a hypervirulent C. difficile ribotype 027 and in vivo (mouse) efficacy compare favorably to vancomycin, and they define AJ-024 as a valuable platform for the development of new anti-C. difficile antibiotics.
Spectroscopy Approach for Highly-Efficient Screening of Lectin-Ligand Interactions in Application for Mannose Receptor and Molecular Containers for Antibacterial Drugs
Authors: Zlotnikov Igor D. , Kudryashova Elena V.
Published: May 2022

Rational search of a ligand for a specific receptor is a cornerstone of a typical drug discovery process. However, to make it more “rational” one would appreciate having detailed information on the functional groups involved in ligand-receptor interaction. Typically, the 3D structure of a ligand-receptor complex can be built on the basis of time-consuming X-ray crystallography data. Here, a combination of FTIR and fluorescence methods, together with appropriate processing, yields valuable information about the functional groups of both the ligand and receptor involved in the interaction, with the simplicity of conventional spectrophotometry. We have synthesized the “molecular containers” based on cyclodextrins, polyethyleneimines (PEI) or spermine with mannose-rich side-chains of different molecular architecture (reticulated, star-shaped and branched) with variable parameters to facilitate delivery to alveolar macrophages. We have shown that synthetic mannose-rich conjugates are highly affine to the model mannose receptor ConA: Kd ≈ 10−5–10−7 M vs. natural ligand trimannoside (10−5 M). Further, it was shown that molecular containers effectively load levofloxacin (dissociation constants are 5·10−4–5·10−6 M) and the eugenol adjuvant (up to 15–80 drug molecules for each conjugate molecule) by including them in the cyclodextrins cavities, as well as by interacting with polymer chains. Promising formulations of levofloxacin and its enhancer (eugenol) in star-shaped and polymer conjugates of high capacity were obtained. UV spectroscopy demonstrated a doubling of the release time of levofloxacin into the external solution from the complexes with conjugates, and the effective action time (time of 80% release) was increased from 0.5 to 20–70 h. The synergy effect of antibacterial activity of levofloxacin and its adjuvants eugenol and apiol on Escherichia coli was demonstrated: the minimum effective concentration of the antibiotic was approximately halved.
Metformin and Cancer, an Ambiguanidous Relationship
Authors: Skuli Sarah J. , Alomari Safwan , Gaitsch Hallie , Bakayoko A’ishah , Skuli Nicolas , Tyler Betty M.
Published: May 2022

The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus, drugs targeting cancer cell metabolism may have promising therapeutic potential. Previous reports demonstrate that the widely used normoglycemic agent, metformin, can decrease the risk of cancer in type 2 diabetics and inhibit cell growth in various cancers, including pancreatic, colon, prostate, ovarian, and breast cancer. While metformin is a known adenosine monophosphate-activated protein kinase (AMPK) agonist and an inhibitor of the electron transport chain complex I, its mechanism of action in cancer cells as well as its effect on cancer metabolism is not clearly established. In this review, we will give an update on the role of metformin as an antitumoral agent and detail relevant evidence on the potential use and mechanisms of action of metformin in cancer. Analyzing antitumoral, signaling, and metabolic impacts of metformin on cancer cells may provide promising new therapeutic strategies in oncology.
Spray-Drying Encapsulation of the Live Biotherapeutic Candidate Akkermansia muciniphila DSM 22959 to Survive Aerobic Storage
Authors: Barbosa Joana , Almeida Diana , Machado Daniela , Sousa Sérgio , Freitas Ana , Andrade José , Gomes Ana
Published: May 2022

Akkermansia muciniphila is regarded as a promising next-generation probiotic or live biotherapeutic candidate. Effective delivery strategies must be developed to ensure high enough viability of the probiotic strain throughout its industrial formulation, distribution chain, shelf-life, and, ultimately, the host’s gastrointestinal tract, where it should exert its beneficial effect(s). Among the possible methodologies, spray-drying is considered industrially attractive regarding its costs, efficiency, and scalability, with the due parameter customization. In this study, spray-drying was explored as a one-step process to encapsulate A. muciniphila DSM 22959, testing the drying settings and three different dairy-based matrices. Microcapsule morphology and size was assessed, and viability throughout storage at 4 or 22 °C and simulated gastrointestinal passage was determined. Akkermansia muciniphila microencapsulation by spray-drying, using 10% skim milk and inlet/outlet temperatures of 150/65 °C, is effective in terms of viability stabilization, both during prolonged aerobic storage and exposure to simulated gastrointestinal passage. Akkermansia muciniphila viability was maintained at around 107 CFU/g up to 28 days at 4 °C under aerobic conditions with viability losses inferior to 1 log reduction. This methodology provides the necessary conditions to efficiently deliver the recommended dose of live A. muciniphila in the human gut as a live biotherapeutic product.
The Influence of Short Motifs on the Anticancer Activity of HB43 Peptide
Authors: Herrera-León Claudia , Ramos-Martín Francisco , El Btaouri Hassan , Antonietti Viviane , Sonnet Pascal , Martiny Laurent , Zevolini Fabrizia , Falciani Chiara , Sarazin Catherine , D’Amelio Nicola
Published: May 2022

Despite the remarkable similarity in amino acid composition, many anticancer peptides (ACPs) display significant differences in terms of activity. This strongly suggests that particular relative dispositions of amino acids (motifs) play a role in the interaction with their biological target, which is often the cell membrane. To better verify this hypothesis, we intentionally modify HB43, an ACP active against a wide variety of cancers. Sequence alignment of related ACPs by ADAPTABLE web server highlighted the conserved motifs that could be at the origin of the activity. In this study, we show that changing the order of amino acids in such motifs results in a significant loss of activity against colon and breast cancer cell lines. On the contrary, amino acid substitution in key motifs may reinforce or weaken the activity, even when the alteration does not perturb the amphipathicity of the helix formed by HB43 on liposomes mimicking their surface. NMR and MD simulations with different membrane models (micelles, bicelles, and vesicles) indicate that the activity reflects the insertion capability in cancer-mimicking serine-exposing membranes, supported by the insertion of N-terminal phenylalanine in the FAK motif and the anchoring to the carboxylate of phosphatidylserine by means of arginine side chains.
Bioactive Loaded Novel Nano-Formulations for Targeted Drug Delivery and Their Therapeutic Potential
Authors: Kumari Sapna , Goyal Anju , Sönmez Gürer Eda , Algın Yapar Evren , Garg Madhukar , Sood Meenakshi , Sindhu Rakesh K.
Published: May 2022

Plant-based medicines have received a lot of attention in recent years. Such medicines have been employed to treat medical conditions since ancient times, and in those times only the observed symptoms were used to determine dose accuracy, dose efficacy, and therapy. Rather than novel formulations, the current research work on plant-based medicines has mostly concentrated on medicinal active phytoconstituents. In the past recent decades, however, researchers have made significant progress in developing “new drug delivery systems” (NDDS) to enhance therapeutic efficacy and reduce unwanted effects of bioactive compounds. Nanocapsules, polymer micelles, liposomes, nanogels, phytosomes, nano-emulsions, transferosomes, microspheres, ethosomes, injectable hydrogels, polymeric nanoparticles, dendrimers, and other innovative therapeutic formulations have all been created using bioactive compounds and plant extracts. The novel formulations can improve solubility, therapeutic efficacy, bioavailability, stability, tissue distribution, protection from physical and chemical damage, and prolonged and targeted administration, to name a few. The current study summarizes existing research and the development of new formulations, with a focus on herbal bioactive components.
Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule 188Re-ZHER2:41071
Authors: Liu Yongsheng , Vorobyeva Anzhelika , Orlova Anna , Konijnenberg Mark W. , Xu Tianqi , Bragina Olga , Loftenius Annika , Rosander Erica , Frejd Fredrik Y. , Tolmachev Vladimir
Published: May 2022

HER2-targeted radionuclide therapy might be helpful for the treatment of breast, gastric, and ovarian cancers which have developed resistance to antibody and antibody-drug conjugate-based therapies despite preserved high HER2-expression. Affibody molecules are small targeting proteins based on a non-immunoglobulin scaffold. The goal of this study was to test in an animal model a hypothesis that the second-generation HER2-targeting Affibody molecule 188Re-ZHER2:41071 might be useful for treatment of HER2-expressing malignant tumors. ZHER2:41071 was efficiently labeled with a beta-emitting radionuclide rhenium-188 (188Re). 188Re-ZHER2:41071 demonstrated preserved specificity and high affinity (KD = 5 ± 3 pM) of binding to HER2-expressing cells. In vivo studies demonstrated rapid washout of 188Re from kidneys. The uptake in HER2-expressing SKOV-3 xenografts was HER2-specific and significantly exceeded the renal uptake 4 h after injection and later. The median survival of mice, which were treated by three injections of 16 MBq 188Re-ZHER2:41071 was 68 days, which was significantly longer (<0.0001 in the log-rank Mantel-Cox test) than survival of mice in the control groups treated with vehicle (29 days) or unlabeled ZHER2:41071 (27.5 days). In conclusion, the experimental radionuclide therapy using 188Re-ZHER2:41071 enabled enhancement of survival of mice with human tumors without toxicity to the kidneys, which is the critical organ.
Solution and Solid-State Optical Properties of Trifluoromethylated 5-(Alkyl/aryl/heteroaryl)-2-methyl-pyrazolo[1,5-a]pyrimidine System
Authors: Stefanello Felipe S. , Vieira Jean C. B. , Araújo Juliane N. , Souza Vitória B. , Frizzo Clarissa P. , Martins Marcos A. P. , Zanatta Nilo , Iglesias Bernardo A. , Bonacorso Helio G.
Published: May 2022

This paper describes the photophysical properties of a series of seven selected examples of 5-(alkyl/aryl/heteroaryl)-2-methyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidines (3), which contain alkyl, aryl, and heteroaryl substituents attached to the scaffolds of 3. Given the electron-donor groups and -withdrawing groups, the optical absorption and emission in the solid state and solution showed interesting results. Absorption UV–Vis and fluorescence properties in several solvents of a pyrazolo[1,5-a]pyrimidines series were investigated, and all derivatives were absorbed in the ultraviolet region despite presenting higher quantum emission fluorescence yields in solution and moderate emission in the solid state. Moreover, the solid-state thermal stability of compounds 3a–g was assessed using thermogravimetric analysis. The thermal decomposition profile showed a single step with almost 100% mass loss for all compounds 3. Additionally, the values of T0.05 are considerably low (72–187 °C), especially for compound 3a (72 °C), indicating low thermal stability for this series of pyrazolo[1,5-a]pyrimidines.
Low-Velocity Impact Response of Auxetic Seamless Knits Combined with Non-Newtonian Fluids
Authors: Pais Vânia , Silva Pedro , Bessa João , Dias Hernâni , Duarte Maria Helena , Cunha Fernando , Fangueiro Raul
Published: May 2022

Low-velocity impact can cause serious damage to the person or structure that is hit. The development of barriers that can absorb the energy of the impact and, therefore, protect the other side of the impact is the ideal solution for the pointed situation. Auxetic materials and shear thickening fluids are two types of technologies that have great capabilities to absorb high levels of energy when an impact happens. Accordingly, within this study, the combination of auxetic knits with shear thickening fluids by the pad-dry-cure process was investigated. It was observed that, by applying knits with auxetic patterns produced with denser materials and combined with the shear thickening fluids, high performance in terms of absorbed energy from puncture impact is obtained. The increment rates obtained are higher than 100% when comparing the structures with and without shear thickening fluids.
Bio-Inspired 4D Printing of Dynamic Spider Silks
Authors: Li Guiwei , Tian Qi , Wu Wenzheng , Yang Shida , Wu Qian , Zhao Yihang , Wang Jiaqing , Zhou Xueli , Wang Kunyang , Ren Luquan , Zhao Ji , Liu Qingping
Published: May 2022

Spider silks exhibit excellent mechanical properties and have promising application prospects in engineering fields. Because natural spider silk fibers cannot be manufactured on a large scale, researchers have attempted to fabricate bio-inspired spider silks. However, the fabrication of bio-inspired spider silks with dynamically tunable mechanical properties and stimulation–response characteristics remains a challenge. Herein, the 4D printing of shape memory polyurethane is employed to produce dynamic bio-inspired spider silks. The bio-inspired spider silks have two types of energy-absorbing units that can be adjusted, one by means of 4D printing with predefined nodes, and the other through different stimulation methods to make the bio-inspired spider silks contract and undergo spiral deformation. The shape morphing behaviors of bio-inspired spider silks are programmed via pre-stress assemblies enabled by 4D printing. The energy-absorbing units of bio-inspired spider silks can be dynamically adjusted owing to stress release generated with the stimuli of temperature or humidity. Therefore, the mechanical properties of bio-inspired spider silks can be controlled to change dynamically. This can further help in developing applications of bio-inspired spider silks in engineering fields with dynamic changes of environment.
Experimental Modal Analysis and Characterization of Additively Manufactured Polymers
Authors: Nguyen Hieu Tri , Crittenden Kelly , Weiss Leland , Bardaweel Hamzeh
Published: May 2022

Modern 3D printed components are finding applications in dynamic structures. These structures are often subject to dynamic loadings. To date, research has mostly focused on investigating the mechanical properties of these 3D printed structures with minimum attention paid to their modal analysis. This work is focused on performing experimental modal analysis of 3D printed structures. The results show that the adhesion type has the most significant impact on the vibration response and parameters obtained from the modal analysis. The average dynamic modulus, natural frequency, and damping coefficient increased by approximately 12.5%, 5.5%, and 36%, respectively, for the specimens printed using skirt adhesion compared to those printed using raft adhesion. SEM analysis suggests that the 3D printed specimens with skirt adhesion yielded flattened layers, while raft adhesion resulted in rounded layers. The flattened layers of the specimens with skirt adhesion are likely an indication of an enhanced heat transfer between the 3D printer bed and the specimen. The printed specimens with skirt adhesion are in direct contact with the printer bed during the printing process. This enhances the heat transfer between the specimen and the printer bed, causing the layers to flatten out. The enhanced heat transfer yields a better inter-layer diffusion, resulting in improved physical bonding at the layers’ interface. The improved bonding yields higher stiffnesses and natural frequencies. For the specimens with skirt adhesion, the improved heat transfer process is also likely responsible for the enhanced damping properties. The strengthened inter-layer bonding at the layer–layer interface provides better energy dissipation along the contact lines between the layers.
Morphology-Controlled Synthesis of Polyphosphazene-Based Micro- and Nano-Materials and Their Application as Flame Retardants
Authors: Zhu Yuanzhao , Wu Wei , Xu Tong , Xu Hong , Zhong Yi , Zhang Linping , Ma Yimeng , Sui Xiaofeng , Wang Bijia , Feng Xueling , Mao Zhiping
Published: May 2022

Common flame retardants, such as halogen-based materials, are being phased-out owing to their harmful environmental and health effects. We prepared poly-(cyclotriphosphazene-co-4,4′-sulfonyldiphenol) (PZS) microspheres, nanotubes, capsicum-like nanotubes, and branched nanotubes as flame retardants. An increase in reaction temperature changed the morphology from nanotubes to microspheres. A PZS shape had a positive effect on the flame retardancy of polyethylene terephthalate (PET). The PZS with a capsicum-like nanotube morphology had the best flame retardancy, and the PET limiting oxygen index increased from 25.2% to 34.4%. The flame retardancy capability was followed by PZS microspheres (33.1%), branched nanotubes (32.8%), and nanotubes (32.5%). The capsicum-like nanotubes promote the formation of highly dense and continuous carbon layers, and they release a non-combustible gas (CO2). This study confirms polyphosphazene-based flame retardants as viable and environmentally-friendly alternatives to common flame retardants. It also presents a novel and facile design and synthesis of morphology-controlled nanomaterials with enhanced flame retardant properties.
A Review on Modeling Cure Kinetics and Mechanisms of Photopolymerization
Authors: Lang Margit , Hirner Stefan , Wiesbrock Frank , Fuchs Peter
Published: May 2022

Photopolymerizations, in which the initiation of a chemical-physical reaction occurs by the exposure of photosensitive monomers to a high-intensity light source, have become a well-accepted technology for manufacturing polymers. Providing significant advantages over thermal-initiated polymerizations, including fast and controllable reaction rates, as well as spatial and temporal control over the formation of material, this technology has found a large variety of industrial applications. The reaction mechanisms and kinetics are quite complex as the system moves quickly from a liquid monomer mixture to a solid polymer. Therefore, the study of curing kinetics is of utmost importance for industrial applications, providing both the understanding of the process development and the improvement of the quality of parts manufactured via photopolymerization. Consequently, this review aims at presenting the materials and curing chemistry of such ultrafast crosslinking polymerization reactions as well as the research efforts on theoretical models to reproduce cure kinetics and mechanisms for free-radical and cationic photopolymerizations including diffusion-controlled phenomena and oxygen inhibition reactions in free-radical systems.
Crosslinked 4-Vinylpyridine Monodisperse Functional Microspheres for Sorption of Ibuprofen and Ketoprofen
Authors: Grochowicz Marta , Szajnecki Łukasz , Rogulska Magdalena
Published: May 2022

Nowadays, ibuprofen and ketoprofen are widely used over-the-counter medications to treat inflammation, fever, or pain. Their high consumption and improper disposal cause them to get into the environment and often pollute surface water. In this study, the new polymeric porous microspheres based on 4-vinylpyridine (4VP) are presented as effective sorbents for ibuprofen and ketoprofen preconcentration and removal. The porous microspheres were obtained via seed swelling polymerization with the use of two types of methacrylate crosslinkers, i.e., trimethylolpropane trimethacrylate (TRIM) and 1,4-dimethacryloiloxybenzene (14DMB). Additionally, as a reference sorbent, a copolymer of styrene and divinylbenzene was obtained. Porous structure investigations showed that the microspheres possess a specific surface area of about 100 m2/g, but noticeable differences were observed in their internal topography depending on the type of crosslinker used. Moreover, the porous structure of dry and swollen microspheres differs significantly. Swollen copolymers reveal the presence of micropores. The 4VP microspheres are characterized by high thermal stability; their initial decomposition temperature is about 300 °C. The performance of the 4VP copolymers as sorbents in aqueous solutions of drugs was evaluated in static and dynamic modes at three pH values of 3, 7, and 11. The highest sorption efficiency was obtained for ibuprofen and ketoprofen in pH 3. Both 4VP copolymers indicate the high sorption capacity in a static sorption as follows: towards ketoprofen of about 40 mg/g whereas towards ibuprofen of about 90 mg/g and 75 mg/g on copolymer crosslinked with trimethylolpropane trimethacrylate and 1,4-dimethacryloiloxybenzene, respectively. The recovery of ibuprofen and ketoprofen after dynamic sorption experiments was higher than 90%.
From Theism to Spirit Beliefs
Authors: Van Eyghen Hans
Published: May 2022

I argue that arguments for the existence of God provide indirect support for the existence of other supernatural beings such as spirits. I defend three arguments: (i) the existence of spirits is more likely if there is a supernatural realm; (ii) an omnibenevolent God makes use of supernatural messengers; (iii) sacred scriptures attest to the existence of spirits. I defend all arguments and defend them against objections.
Equipping Families and Friends to Offer Spiritual Care to People Living with Dementia: Findings from a Meta-Synthesis
Authors: Jackson Darrell , Erwich René , Flynn Eleanor , Olorunnisola Titus S.
Published: May 2022

Our work presents a meta-synthesis of 76 peer-reviewed, qualitative-research journal articles related to our research interest in the spiritual care training available for relatives and friends of people living with dementia. A total of 244 articles was reviewed prior to the application of selection criteria. The final sample of 2698 research participants across our selection of 76 peer-reviewed qualitative-research studies serves to demonstrate the value of spiritual care as an aspect of holistic palliative and dementia care. The development and implementation of spiritual-care standards and practices in healthcare generally is increasingly widespread. Most current training resources are designed for healthcare professionals, and our meta-synthesis identifies the need for training resources that equip and train volunteer spiritual carers, namely, the relatives and friends of people living with dementia. Our meta-synthesis suggests there is a need to develop training resources that equip relatives and friends with skills that prioritise attentive presence, spiritual intelligence, emotional intelligence, and, primarily, sensory spiritual practices. Beyond this meta-synthesis, developing and trialling suitable training materials and events will become the focus of an action research project.
Analysis Ready Data: Enabling Analysis of the Landsat Archive
Authors: Dwyer John L. , Roy David P. , Sauer Brian , Jenkerson Calli B. , Zhang Hankui K. , Lymburner Leo
Published: May 2022

Data that have been processed to allow analysis with a minimum of additional user effort are often referred to as Analysis Ready Data (ARD). The ability to perform large scale Landsat analysis relies on the ability to access observations that are geometrically and radiometrically consistent, and have had non-target features (clouds) and poor quality observations flagged so that they can be excluded. The United States Geological Survey (USGS) has processed all of the Landsat 4 and 5 Thematic Mapper (TM), Landsat 7 Enhanced Thematic Mapper Plus (ETM+), Landsat 8 Operational Land Imager (OLI) and Thermal Infrared Sensor (TIRS) archive over the conterminous United States (CONUS), Alaska, and Hawaii, into Landsat ARD. The ARD are available to significantly reduce the burden of pre-processing on users of Landsat data. Provision of pre-prepared ARD is intended to make it easier for users to produce Landsat-based maps of land cover and land-cover change and other derived geophysical and biophysical products. The ARD are provided as tiled, georegistered, top of atmosphere and atmospherically corrected products defined in a common equal area projection, accompanied by spatially explicit quality assessment information, and appropriate metadata to enable further processing while retaining traceability of data provenance.
Hybrid Methodology Using Sentinel-1/Sentinel-2 for Soil Moisture Estimation
Authors: Nativel Simon , Ayari Emna , Rodriguez-Fernandez Nemesio , Baghdadi Nicolas , Madelon Remi , Albergel Clement , Zribi Mehrez
Published: May 2022

Soil moisture is an essential parameter for a better understanding of water processes in the soil–vegetation–atmosphere continuum. Satellite synthetic aperture radar (SAR) is well suited for monitoring water content at fine spatial resolutions on the order of 1 km or higher. Several methodologies are often considered in the inversion of SAR signals: machine learning techniques, such as neural networks, empirical models and change detection methods. In this study, we propose two hybrid methodologies by improving a change detection approach with vegetation consideration or by combining a change detection approach together with a neural network algorithm. The methodology is based on Sentinel-1 and Sentinel-2 data with the use of numerous metrics, including vertical–vertical (VV) and vertical–horizontal (VH) polarization radar signals, the classical change detection surface soil moisture (SSM) index ISSM, radar incidence angle, normalized difference vegetation index (NDVI) optical index, and the VH/VV ratio. Those approaches are tested using in situ data from the ISMN (International Soil Moisture Network) with observations covering different climatic contexts. The results show an improvement in soil moisture estimations using the hybrid algorithms, in particular the change detection with the neural network one, for which the correlation increases by 54% and 33% with respect to that of the neural network or change detection alone, respectively.
Sentinel-1 SAR Backscatter Response to Agricultural Drought in The Netherlands
Authors: Shorachi Maurice , Kumar Vineet , Steele-Dunne Susan C.
Published: May 2022

Drought is a major natural hazard that impacts agriculture, the environment, and socio-economic conditions. In 2018 and 2019, Europe experienced a severe drought due to below average precipitation and high temperatures. Drought stress affects the moisture content and structure of agricultural crops and can result in lower yields. Synthetic Aperture Radar (SAR) observations are sensitive to the dielectric and geometric characteristics of crops and underlying soils. This study uses data from ESA’s Sentinel-1 SAR satellite to investigate the influence of drought stress on major arable crops of the Netherlands, its regional variability and the impact of water management decisions on crop development. Sentinel-1 VV, VH and VH/VV backscatter data are used to quantify the variability in the spatio-temporal dynamics of agricultural crop parcels in response to drought. Results show that VV and VH backscatter values are 1 to 2 dB lower for crop parcels during the 2018 drought compared to values in 2017. In addition, the growth season indicated by the cross-ratio (CR, VH/VV) for maize and onion is shorter during the drought year. Differences due to irrigation restrictions are observed in backscatter response from maize parcels. Lower CR values in 2019 indicate the impact of drought on the start of the growing season. Results demonstrate that Sentinel-1 can detect changes in the seasonal cycle of arable crops in response to agricultural drought.
The Iterative Extraction of the Boundary of Coherence Region and Iterative Look-Up Table for Forest Height Estimation Using Polarimetric Interferometric Synthetic Aperture Radar Data
Authors: Huang Zenghui , Yun Ye , Chai Huiming , Lv Xiaolei
Published: May 2022

In this paper, we introduce a refined three-stage inversion algorithm (TSIA) for forest height estimation using polarimetric interferometric synthetic aperture radar (PolInSAR). Specifically, the iterative extraction of the boundary of the coherence region (IEBCR) and iterative look-up table (ILUT) are proposed to improve the efficiency of traditional TSIA. A class of refined TSIA utilizes the boundary of the coherence region (BCR) to alleviate the underestimation phenomenon in forest height estimation. Given many eigendecompositions in the extraction of BCR (EBCR), we analyze the relationship of eigenvectors between the adjacent points on the BCR and propose the IEBCR utilizing the power methods. In the final inversion stage of TSIA, the look-up table (LUT) uses the exhaustive search method to minimize the loss function in the 2-D grid with defined step sizes and thus costs high computational complexity. To alleviate the deficiency, we define the random volume over ground (RVoG) function based on the RVoG model and prove its monotonicity and convergence from the analytical and numerical points of view. After analyzing the relationship between the RVoG function and the loss function, we propose the ILUT for the inversion stage. The simulation and experiments based on the BioSAR 2008 campaign data illustrate that the IEBCR and ILUT greatly improve the computational efficiency almost without compromising on accuracy.
Formulation of a Structural Equation Relating Remotely Sensed Electron Transport Rate Index to Photosynthesis Activity
Authors: Liran Oded
Published: May 2022

Chlorophyll fluorescence can be remotely sensed in open fields via the Fraunhofer atmospheric absorption lines of oxygen and is termed Solar-Induced Fluorescence (SIF). SIF has been extensively related to carbon assimilation at global ecology scale and was interpreted as electron transport rate. However, SIF was shown to be unrelated directly to carbon assimilation at finer-scale resolution and may be related to other photosynthetic processes, such as non-photochemical quenching. This raises the question how exactly the SIF relates to actual photosynthetic activity. Based on a recently introduced spectral index that relates the photochemical fraction of SIF to the actual electron transport rate, this study presents the formulation of a structural equation, relating the remotely sensed electron transport rate index to fluorescence yield which considers the various fates of energetic quanta and electron excitation. The proposed structural equations are used to examine and interpret the relation between the novel spectral index and seasonal growth of corn (Z. mays Sh2, ‘super sweet’) on a platform of fertilization concentration gradient. Potential uses, practical and theoretical, for the proposed structural equations are discussed.
PFD-SLAM: A New RGB-D SLAM for Dynamic Indoor Environments Based on Non-Prior Semantic Segmentation
Authors: Zhang Chenyang , Zhang Rongchun , Jin Sheng , Yi Xuefeng
Published: May 2022

Now, most existing dynamic RGB-D SLAM methods are based on deep learning or mathematical models. Abundant training sample data is necessary for deep learning, and the selection diversity of semantic samples and camera motion modes are closely related to the robust detection of moving targets. Furthermore, the mathematical models are implemented at the feature-level of segmentation, which is likely to cause sub or over-segmentation of dynamic features. To address this problem, different from most feature-level dynamic segmentation based on mathematical models, a non-prior semantic dynamic segmentation based on a particle filter is proposed in this paper, which aims to attain the motion object segmentation. Firstly, GMS and optical flow are used to calculate an inter-frame difference image, which is considered an observation measurement of posterior estimation. Then, a motion equation of a particle filter is established using Gaussian distribution. Finally, our proposed segmentation method is integrated into the front end of visual SLAM and establishes a new dynamic SLAM, PFD-SLAM. Extensive experiments on the public TUM datasets and real dynamic scenes are conducted to verify location accuracy and practical performances of PFD-SLAM. Furthermore, we also compare experimental results with several state-of-the-art dynamic SLAM methods in terms of two evaluation indexes, RPE and ATE. Still, we provide visual comparisons between the camera estimation trajectories and ground truth. The comprehensive verification and testing experiments demonstrate that our PFD-SLAM can achieve better dynamic segmentation results and robust performances.
Hyperspectral Image Classification Based on Non-Parallel Support Vector Machine
Authors: Liu Guangxin , Wang Liguo , Liu Danfeng , Fei Lei , Yang Jinghui
Published: May 2022

Support vector machine (SVM) has a good effect in the supervised classification of hyperspectral images. In view of the shortcomings of the existing parallel structure SVM, this article proposes a non-parallel SVM model. Based on the traditional parallel boundary structure vector machine, this model adds an additional empirical risk minimization term to the original optimization problem by adding the least square term of the sample and obtains two non-parallel hyperplanes, respectively, forming a new non-parallel SVM algorithm to minimize the additional empirical risk of non-parallel SVM (Additional Empirical Risk Minimization Non-parallel Support Vector Machine, AERM-NPSVM). On the basis of AERM-NPSVM, the bias constraint is added to it, and AERM-NPSVM (BC-AERM-NPSVM) is further obtained. The experimental results show that, compared with the traditional parallel SVM model and the classical non-parallel SVM model, Twin Support Vector Machine (TWSVM), the new model, has a better effect in hyperspectral image classification and better generalization performance.