bluuebunny/crossref_metadata_2025 huggingface dataset:
Arsenic Metabolism, Toxicity and Accumulation in the White Button Mushroom Agaricus bisporus
Authors: Dong Owen , Powers Michael , Liu Zijuan , Yoshinaga Masafumi
Published: September 2022

Mushrooms have unique properties in arsenic metabolism. In many commercial and wild-grown mushrooms, arsenobetaine (AsB), a non-toxic arsenical, was found as the dominant arsenic species. The AsB biosynthesis remains unknown, so we designed experiments to study conditions for AsB formation in the white button mushroom, Agaricus bisporus. The mushrooms were treated with various arsenic species including arsenite (As(III)), arsenate (As(V)), methylarsenate (MAs(V)), dimethylarsenate (DMAs(V)) and trimethylarsine oxide (TMAsO), and their accumulation and metabolism were determined using inductively coupled mass spectrometer (ICP-MS) and high-pressure liquid chromatography coupled with ICP-MS (HPLC-ICP-MS), respectively. Our results showed that mycelia have a higher accumulation for inorganic arsenicals while fruiting bodies showed higher accumulation for methylated arsenic species. Two major arsenic metabolites were produced in fruiting bodies: DMAs(V) and AsB. Among tested arsenicals, only MAs(V) was methylated to DMAs(V). Surprisingly, AsB was only detected as the major arsenic product when TMAsO was supplied. Additionally, AsB was only detected in the fruiting body, but not mycelium, suggesting that methylated products were transported to the fruiting body for arsenobetaine formation. Overall, our results support that methylation and AsB formation are two connected pathways where trimethylated arsenic is the optimal precursor for AsB formation.
Evaluation of Bisphenol A in Pregnant Women from 10 Caribbean Countries
Authors: Forde Martin S. , Côté Suzanne , Laouan Sidi Elhadji A. , Gaudreau Éric , Ayotte Pierre
Published: September 2022

Bisphenol A (BPA), a phenolic chemical incorporated into many plastic products, has been found to act as an endocrine disruptor that potentially is linked to adverse neurodevelopmental outcomes. Prenatal BPA concentration levels were assessed in 10 English-speaking Caribbean countries by randomly selecting 15 maternal urine samples from approximately 50 pregnant women samples collected in each island and then comparing the findings with comparable data from Canada and the U.S. BPA was detected in all samples ranging from a low geometric mean of 1.46 μg/L (St. Lucia) to a high of 4.88 μg/L (St. Kitts & Nevis). All of the Caribbean islands sampled had geometric mean concentration levels that were higher than those recorded in two Canadian biomonitoring surveys (1.26 μg/L and 0.80 μg/L) and the U.S. NHANES survey (1.39 μg/L). This first biomonitoring survey of BPA concentration levels in maternal urine samples taken from Caribbean countries clearly points to the need for Caribbean governments and public health officials to first engage in legislative and regulatory efforts to ban or minimize the importation and use of BPA products used the Caribbean and, second, to continue to conduct biomonitoring surveys so as to ensure that these laws and regulations are indeed leading to a decrease of BPA concentrations in Caribbean populations.
Event-Based Anomaly Detection for Searches for New Physics
Authors: Chekanov Sergei , Hopkins Walter
Published: September 2022

This paper discusses model-agnostic searches for new physics at the Large Hadron Collider using anomaly-detection techniques for the identification of event signatures that deviate from the Standard Model (SM). We investigate anomaly detection in the context of a machine-learning approach based on autoencoders. The analysis uses Monte Carlo simulations for the SM background and several selected exotic models. We also investigate the input space for the event-based anomaly detection and illustrate the shapes of invariant masses in the outlier region which will be used to perform searches for resonant phenomena beyond the SM. Challenges and conceptual limitations of this approach are discussed.
Metalloprotease-Dependent S2′-Activation Promotes Cell–Cell Fusion and Syncytiation of SARS-CoV-2
Authors: Harte James V. , Wakerlin Samantha L. , Lindsay Andrew J. , McCarthy Justin V. , Coleman-Vaughan Caroline
Published: September 2022

SARS-CoV-2 cell–cell fusion and syncytiation is an emerging pathomechanism in COVID-19, but the precise factors contributing to the process remain ill-defined. In this study, we show that metalloproteases promote SARS-CoV-2 spike protein-induced syncytiation in the absence of established serine proteases using in vitro cell–cell fusion assays. We also show that metalloproteases promote S2′-activation of the SARS-CoV-2 spike protein, and that metalloprotease inhibition significantly reduces the syncytiation of SARS-CoV-2 variants of concern. In the presence of serine proteases, however, metalloprotease inhibition does not reduce spike protein-induced syncytiation and a combination of metalloprotease and serine protease inhibition is necessitated. Moreover, we show that the spike protein induces metalloprotease-dependent ectodomain shedding of the ACE2 receptor and that ACE2 shedding contributes to spike protein-induced syncytiation. These observations suggest a benefit to the incorporation of pharmacological inhibitors of metalloproteases into treatment strategies for patients with COVID-19.
Origin of New Lineages by Recombination and Mutation in Avian Infectious Bronchitis Virus from South America
Authors: Marandino Ana , Vagnozzi Ariel , Tomás Gonzalo , Techera Claudia , Gerez Rocío , Hernández Martín , Williman Joaquín , Realpe Mauricio , Greif Gonzalo , Panzera Yanina , Pérez Ruben
Published: September 2022

The gammacoronavirus avian infectious bronchitis virus (IBV) is a highly contagious respiratory pathogen of primary economic importance to the global poultry industry. Two IBV lineages (GI-11 and GI-16) have been widely circulating for decades in South America. GI-11 is endemic to South America, and the GI-16 is globally distributed. We obtained full-length IBV genomes from Argentine and Uruguayan farms using Illumina sequencing. Genomes of the GI-11 and GI-16 lineages from Argentina and Uruguay differ in part of the spike coding region. The remaining genome regions are similar to the Chinese and Italian strains of the GI-16 lineage that emerged in Asia or Europe in the 1970s. Our findings support that the indigenous GI-11 strains recombine extensively with the invasive GI-16 strains. During the recombination process, GI-11 acquired most of the sequences of the GI-16, retaining the original S1 sequence. GI-11 strains with recombinant genomes are circulating forms that underwent further local evolution. The current IBV scenario in South America includes the GI-16 lineage, recombinant GI-11 strains sharing high similarity with GI-16 outside S1, and Brazilian GI-11 strains with a divergent genomic background. There is also sporadic recombinant in the GI-11 and GI-16 lineages among vaccine and field strains. Our findings exemplified the ability of IBV to generate emergent lineage by using the S gene in different genomic backgrounds. This unique example of recombinational microevolution underscores the genomic plasticity of IBV in South America.
Correction: Mase et al. Genetic Analysis of the Complete S1 Gene in Japanese Infectious Bronchitis Virus Strains. Viruses 2022, 14, 716
Authors: Mase Masaji , Hiramatsu Kanae , Watanabe Satoko , Iseki Hiroshi
Published: September 2022

In the original publication [...]
Viral Agents as Potential Drivers of Diffuse Large B-Cell Lymphoma Tumorigenesis
Authors: Bilajac Esma , Mahmutović Lejla , Lundstrom Kenneth , Glamočlija Una , Šutković Jasmin , Sezer Abas , Hromić-Jahjefendić Altijana
Published: September 2022

Among numerous causative agents recognized as oncogenic drivers, 13% of total cancer cases occur as a result of viral infections. The intricacy and diversity of carcinogenic processes, however, raise significant concerns about the mechanistic function of viruses in cancer. All tumor-associated viruses have been shown to encode viral oncogenes with a potential for cell transformation and the development of malignancies, including diffuse large B-cell lymphoma (DLBCL). Given the difficulties in identifying single mechanistic explanations, it is necessary to combine ideas from systems biology and viral evolution to comprehend the processes driving viral cancer. The potential for more efficient and acceptable therapies lies in targeted medicines that aim at viral proteins or trigger immune responses to either avoid infection or eliminate infected or cancerous cells. In this review, we aim to describe the role of viral infections and their mechanistic approaches in DLBCL tumorigenesis. To the best of our knowledge, this is the first review summarizing the oncogenic potential of numerous viral agents in DLBCL development.
Biolayer Interferometry Analysis for a Higher Throughput Quantification of In-Process Samples of a Rotavirus Vaccine
Authors: Carvalho Sofia B. , Dias Mafalda M. , Matheise Jean-Philippe , Knott Isabelle , Gomes-Alves Patrícia , Alves Paula M.
Published: September 2022

Rotavirus A infection is a global leading cause of severe acute gastroenteritis associated with life-threatening diarrheal episodes in infants and young children. The disease burden is being reduced, namely due to a wider access to rotavirus vaccines. However, there is a demand to expand rotavirus vaccination programs, and to achieve this, it is critical to improve high-throughput in-process product quality control and vaccine manufacturing monitoring. Here, we present the development of an analytical method for the quantification of rotavirus particles contained in a licensed vaccine. The binding of rotavirus proteins to distinct glycoconjugate receptors and monoclonal antibodies was evaluated using biolayer interferometry analysis, applied on an Octet platform. The antibody strategy presented the best results with a linear response range within 2.5 × 107–1.0 × 108 particles·mL−1 and limits of detection and quantification of 2.5 × 106 and 7.5 × 106 particles·mL−1, respectively. Method suitability for the quantification of in-process samples was shown using samples from different manufacturing stages and their titers were comparable with the approved CCID(50) method. This cell-free method enables a fast and high-throughput analysis, compatible with time constraints during bioprocess development and it is suitable to be adapted to other viral particle-based drug products.
Recent Advances in DNA Vaccines against Lung Cancer: A Mini Review
Authors: Huang Ting , Liu Li , Lv Zheng , Zhao Kelei , Yi Qiong , Zhang Jing
Published: September 2022

Lung cancer is regarded as the major causes of patient death around the world. Although the novel tumor immunotherapy has made great progress in the past decades, such as utilizing immune checkpoint inhibitors or oncolytic viruses, the overall 5-year survival of patients with lung cancers is still low. Thus, development of effective vaccines to treat lung cancer is urgently required. In this regard, DNA vaccines are now considered as a promising immunotherapy strategy to activate the host immune system against lung cancer. DNA vaccines are able to induce both effective humoral and cellular immune responses, and they possess several potential advantages such as greater stability, higher safety, and being easier to manufacture compared to conventional vaccination. In the present review, we provide a global overview of the mechanism of cancer DNA vaccines and summarize the innovative neoantigens, delivery platforms, and adjuvants in lung cancer that have been investigated or approved. Importantly, we highlight the recent advance of clinical studies in the field of lung cancer DNA vaccine, focusing on their safety and efficacy, which might accelerate the personalized design of DNA vaccine against lung cancer.
Identification of Shared Neoantigens in BRCA1-Related Breast Cancer
Authors: Ruangapirom Lucksica , Sutivijit Nannapat , Teerapakpinyo Chinachote , Mutirangura Apiwat , Doungkamchan Chatchanan
Published: September 2022

Personalized neoantigen-based cancer vaccines have been shown to be safe and immunogenic in cancer patients; however, the manufacturing process can be costly and bring about delays in treatment. Using off-the-shelf cancer vaccines targeting shared neoantigens may circumvent these problems. Unique mutational signatures and similar phenotypes found among BRCA1-mutated breast cancer make it an ideal candidate for discovering shared neoantigens within the group. We obtained genome sequencing data of breast cancer samples with or without somatic BRCA1 mutations (BRCA1-positive and BRCA1-negative, respectively) from the three public cancer databases; The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), and Catalogue of Somatic Mutations in Cancer (COSMIC); and from three studies with whole genome/exome sequencing data of samples with germline BRCA1 mutations. Data were analyzed separately within the same database/cohort. We found PIK3CA H1047R, E545K, E542K, and N345K recurrently in BRCA1-negative groups across all databases, whereas recurrent somatic mutations in BRCA1-positive groups were discordant among databases. For germline BRCA1-mutated breast cancer, TP53 R175H was unanimously the most frequent mutation among the three germline cohorts. Our study provides lists of potential shared neoantigens among BRCA1-related breast cancer, which may be used in developing off-the-shelf neoantigen-based vaccines.
Immunoinformatics Studies and Design of a Potential Multi-Epitope Peptide Vaccine to Combat the Fatal Visceral Leishmaniasis
Authors: Onile Olugbenga Samson , Musaigwa Fungai , Ayawei Nimibofa , Omoboyede Victor , Onile Tolulope Adelonpe , Oghenevovwero Eyarefe , Aruleba Raphael Taiwo
Published: September 2022

Leishmaniasis is a neglected tropical disease caused by parasitic intracellular protozoa of the genus Leishmania. The visceral form of this disease caused by Leishmania donovani continues to constitute a major public health crisis, especially in countries of endemicity. In some cases, it is asymptomatic and comes with acute and chronic clinical outcomes such as weight loss, pancytopenia, hepatosplenomegaly, and death if left untreated. Over the years, the treatment of VL has relied solely on chemotherapeutic agents, but unfortunately, these drugs are now faced with challenges. Despite all efforts, no successful vaccine has been approved for VL. This could be as a result of limited knowledge/understanding of the immune mechanisms necessary to regulate parasite growth. Using a computational approach, this study explored the prospect of harnessing the properties of a disulfide isomerase protein of L. donovani amastigotses to develop a multi-epitope subunit vaccine candidate against the parasite. We designed a 248-amino acid multi-epitope vaccine with a predicted antigenicity probability of 0.897372. Analyses of immunogenicity, allergenicity, and multiple physiochemical parameters indicated that the constructed vaccine candidate was stable, non-allergenic, and immunogenic, making it compatible with humans and hence, a potentially viable and safe vaccine candidate against Leishmania spp. Parasites.
Real Time Predictive and Adaptive Hybrid Powertrain Control Development via Neuroevolution
Authors: Jacquelin Frederic , Bae Jungyun , Chen Bo , Robinette Darrell , Santhosh Pruthwiraj , Kraemer Troy , Henderson Bonnie
Published: September 2022

The real-time application of powertrain-based predictive energy management (PrEM) brings the prospect of additional energy savings for hybrid powertrains. Torque split optimal control methodologies have been a focus in the automotive industry and academia for many years. Their real-time application in modern vehicles is, however, still lagging behind. While conventional exact and non-exact optimal control techniques such as Dynamic Programming and Model Predictive Control have been demonstrated, they suffer from the curse of dimensionality and quickly display limitations with high system complexity and highly stochastic environment operation. This paper demonstrates that Neuroevolution associated drive cycle classification algorithms can infer optimal control strategies for any system complexity and environment, hence streamlining and speeding up the control development process. Neuroevolution also circumvents the integration of low fidelity online plant models, further avoiding prohibitive embedded computing requirements and fidelity loss. This brings the prospect of optimal control to complex multi-physics system applications. The methodology presented here covers the development of the drive cycles used to train and validate the neurocontrollers and classifiers, as well as the application of the Neuroevolution process.
Stuttering Priapism in a Dog—First Report
Authors: Roux Françoise A. , Le Breuil Florian , Branchereau Julien , Deschamps Jack-Yves
Published: September 2022

A 5-year-old recently castrated male Doberman dog presented for prolonged erection of one week’s duration with associated pain and dysuria. This was the fourth episode within a year. Each episode was associated with an unusual event, which was stressful for the dog. Castration performed two months prior to the final episode did not prevent recurrence. Due to tissue necrosis, penile amputation and urethrostomy had to be performed. The dog recovered fully. Prolonged erection that persists beyond or that is unrelated to sexual stimulation is called “priapism”. This term refers to the Greek god Priapus, a god of fertility, memorialized in sculptures for his giant phallus. In humans, depending on the mechanism involved, priapism is classified as nonischemic or ischemic. Because prognosis and treatment are different, priapism must be determined to be nonischemic or ischemic. Nonischemic priapism is a rare condition observed when an increase in penile arterial blood flow overwhelms the capacity of venous drainage; it is often associated with penile trauma, and does not require medical intervention. Ischemic priapism is associated with decreased venous return. In humans, ischemic priapism accounts for 95% of cases, the majority of which are idiopathic. Ischemic priapism is a urological emergency; simple conservative measures such as aspiration of blood from the corpora cavernosa and intracavernosal injection of an adrenergic agent are often successful. Stuttering priapism, also called recurrent or intermittent priapism, is a particular form of ischemic priapism reported in humans that is characterized by repetitive episodes of prolonged erections. Management consists of treating each new episode as an episode of acute ischemic priapism, and preventing recurrence with oral medications such as dutasteride and/or baclofen, gabapentin, or tadalafil. To the authors’ knowledge, this case is the first report of stuttering priapism in a dog.
Fibroblast Growth Factor-2 (FGF-2) Expression in Pterygia Using Cell Spot Arrays
Authors: Mastronikolis Stylianos , Tsiambas Evangelos , Kagkelaris Konstantinos , Pagkalou Marina , Plotas Panagiotis , Mastronikoli Sofianiki , Roukas Dimitrios , Georgakopoulos Constantinos D.
Published: September 2022

Fibroblast growth factor (FGF) is a main regulator of cell differentiation, cell migration and angiogenesis in normal and abnormal conjunctiva epithelia, but specific mechanisms of its aberrant expression are yet to be investigated. In the present study, we investigated FGF-2 protein expression within several pterygia. Using a liquid-based cytology assay, we obtained cell specimens from pterygia and healthy tissues directly from patients. A combination of immunocytochemistry followed by digital image analysis showed significant overexpression of FGF-2 in all the examined pterygia. In 30/60 (50%) cases there were high levels of staining intensity, whereas in the remaining 30/60 (50%) cases there were moderate levels of expression. FGF-2 levels of the control group were significantly lower in comparison with the pterygia group. There was no significant correlation between FGF-2 levels and either sex or location of the pterygium. FGF-2 levels had a significant correlation with morphological characteristics of the pterygia. More specifically, FGF-2 levels were significantly higher in the pterygia with a fleshy morphology. Interestingly, recurrent lesions demonstrated high expression levels. An overexpression of FGF-2 has been observed frequently in pterygia, where it may play a crucial role in determining the lesion’s progression. FGF-2 upregulation correlates with the morphology of pterygia and its tendency to recur. Cell spot analysis based on liquid-based cytology is a simple, yet effective, method for detecting a broad spectrum of protein markers and could be useful in analyzing potential pterygia patient samples.
The Colours of Octopus: Using Spectral Data to Measure Octopus Camouflage
Authors: Nahmad-Rohen Luis , Qureshi Yusuf H. , Vorobyev Misha
Published: September 2022

No animal can so effectively camouflage in such a wide range of environments as the octopus. Thanks to their highly malleable skin, they are capable of adapting their body patterns to the brightness and texture of their immediate environment, and they often seemingly match the colour of background objects. However, octopuses are colour-blind as their eyes have only one type of visual pigment. Therefore, chromatophores in their skin are likely to respond to changes in brightness, not chromaticity. To determine whether octopuses actually match background colours, we used a SpectraScan® PR-655 spectroradiometer to measure the reflectance spectra of Octopus tetricus skin in captivity. The spectra were compared with those of green algae, brown algae, and sponges—all of these being colourful objects commonly found in the octopus’s natural environment. Even though we show that octopuses change both lightness and chromaticity, allowing them to potentially camouflage in a wide range of backgrounds in an effective manner, the overall octopus colours did not reach the same level of saturation compared to some background objects. Spectra were then modelled under the visual systems of four potential octopus predators: one dichromatic fish (Heller’s barracuda), two trichromatic fish (blue-spotted stingray and two-spotted red snapper), and one tetrachromatic bird (wedge-tailed shearwater). We show that octopuses are able to match certain background colours for some visual systems. How a colour-blind animal is capable of colour-matching is still unknown.
Comparison of Two Convergence Criterion in the Optimization Process Using a Recursive Method in a Multi-Reservoir System
Authors: Mendoza-Ramírez Rosalva , Silva Rodolfo , Domínguez-Mora Ramón , Juan-Diego Eduardo , Carrizosa-Elizondo Eliseo
Published: September 2022

Stochastic dynamic programming (SDP) is an optimization technique used in the operation of reservoirs for many years. However, being an iterative method requiring considerable computational time, it is important to establish adequate convergence criterion for its most effective use. Based on two previous studies for the optimization of operations in one of the most important multi-reservoir systems in Mexico, this work uses SDP, centred on the interest in the convergence criterion used in the optimization process. In the first trial, following the recommendations in the literature consulted, the difference in the absolute value of two consecutive iterations was taken and compared against a set tolerance value and a discount factor. In the second trial, it was decided to take the squared difference of the two consecutive iterations. In each of the trials, the computational time taken to obtain the optimal operating policy was quantified, along with whether the optimal operating policy was obtained by meeting the convergence criterion or by reaching the maximum number of iterations. With each optimization policy, the operation of the system under study was simulated and four variables were taken as evaluators of the system behaviour. The results showed few differences in the two operation policies but notable differences in the computation time used in the optimization process, as well as in the fulfilment of the convergence criterion.
Accounting for Climate Change in Extreme Sea Level Estimation
Authors: D’Arcy Eleanor , Tawn Jonathan A. , Sifnioti Dafni E.
Published: September 2022

Extreme sea level estimates are fundamental for mitigating coastal flooding as they provide insight for defence engineering. As the global climate changes, rising sea levels combined with increases in storm intensity and frequency pose an increasing risk to coastline communities. We present a new method for estimating extreme sea levels that accounts for the effects of climate change on extreme events that are not accounted for by mean sea level trends. We follow a joint probabilities methodology, considering skew surge and peak tides as the only components of sea levels. We model extreme skew surges using a non-stationary generalised Pareto distribution (GPD) with covariates accounting for climate change, seasonality and skew surge–peak tide interaction. We develop methods to efficiently test for extreme skew surge trends across different coastlines and seasons. We illustrate our methods using data from four UK tide gauges and estimate sea level return levels when accounting for these long-term trends.
Is Investment Contributing to Competitiveness in Nautical Tourism in the Atlantic Area?
Authors: Santos Eleonora , Castanho Rui Alexandre , Meyer Daniel
Published: September 2022

The blue economy contributes significantly to the creation of the Atlantic Area’s identity. In addition, the search for outdoor experiences after the COVID-19 lockdown suspensions has renewed the popularity of nautical tourism in this area and in the world. Despite the negative effects of the economic crisis on tourism, evidence suggests that some tourist destinations in the Atlantic area are resilient. Thus, whereas some branches of the blue economy face considerable challenges to increasing competitiveness, others offer opportunities for economic growth and employment. In this context, investment is necessary to lay the foundations for the sustainable development of nautical tourism. However, regarding the role of investment in productivity and competitiveness in the context of crisis, there is no consensus among academics. Thus, we investigate whether the investment contributed to competitiveness in nautical tourism in the Atlantic Area in 2016–2020. We collected data from ORBIS for 29 nautical-tourism companies and performed a quantitative and qualitative narrative analysis of competitiveness indicators, enabling comparisons pre and during crisis. The results highlight the multiplicity of ways in which crisis impacts nautical-tourism firms. The research fills a gap in the literature by investigating the dynamic capabilities of nautical-tourism SMEs in periods of recession, with a special focus on restructuring and competitiveness strategies. Some recommendations are outlined to promote the efficiency of resources and stimulate the competitiveness of companies to allow the regional development of nautical tourism in the territory of the Atlantic area.
The Impact of Dissolved Organic Matter on Arsenic Mobilization from Goethite in the Presence of Silicic Acid and Phosphate under Reducing Conditions
Authors: Aftabtalab Adeleh , Moreno-Jiménez Eduardo , Henschel Jonas , Nowak Sascha , Schaller Jörg , Knorr Klaus-Holger
Published: September 2022

The release of arsenic (As) adsorbed onto iron oxide (Fe-oxide) surfaces is affected by dissolved organic matter (DOM), phosphate (hereafter referred to as PO4), and silicic acid (H4SiO4). Further, the reductive dissolution of As from Fe-oxide phases is also affected in reduced soils and sediments. Thus, the aim of this study was to understand the adsorption competition and redox-related mechanisms by which DOM affects As mobilization from Fe-oxide in a complex system containing both H4SiO4 and PO4. The results demonstrated that the DOM-driven, microbially mediated As biotransformation, and, thus, mobilization of As significantly increased when both dissolved inorganic H4SiO4 and PO4 were present, as the co-presence of H4SiO4 and PO4 decreased As adsorption sites on Fe-oxides. The availability of DOM in the co-presence of H4SiO4 and PO4 increased the microbial activity in the system by providing more substrates for microbial metabolism, which also decreased the redox potential (reducing conditions) and consumed acidity, causing the pH to increase from 4 to 6.8. In addition, DOM, H4SiO4, and PO4 competed with As for sorption sites on Fe-oxides. The effects of DOM on As mobility by DOM-mediated or -triggered redox reactions were apparently stronger in the co-presence of H4SiO4 and PO4 than DOM competition with arsenate for sorption sites on Fe-oxide alone. These findings advance our understanding of As mobilization processes in natural systems and can provide information for soil As management.
Divalent Lead in Aqueous Solution Changes the Surface Morphology of Dolomite and Inhibits Dissolution
Authors: Li Liang , Wu Bingjin , Guan Tianyu , Wang Wenhai , Wei Dongwen
Published: September 2022

In groundwater systems, heavy metal ions as solutes (e.g., Pb) can adsorb onto the surface of calcite group rocks and influence their dissolution processes. The dolomite surface was examined using field emission scanning electron microscopy (SEM) and various characterization tools and the changes in water chemistry indexes were reviewed throughout the dissolution process. Pb adsorption on the dolomite surface was evident after 15 days of exposure to 1 mg/L or 50 mg/L divalent Pb salt solutions; the Pb surface phase was mainly PbCO3 with an octahedral ligand structure. SEM images show that dolomite in divalent Pb salt solutions can lead to the surface morphology exhibiting curved dissolution steps. In the closed system with Pb (1 mg/L), the total alkalinity and conductivity of the solution were lower than in the Pb-free system, and the pH difference was slight, indicating that the dibasic metal ion Pb inhibited the dolomite dissolution process. Combined with the composition of the final solid phase, it is suggested that the dolomite surface preferentially adsorbs Pb2+ on the active sites and that the newly grown solid phase is PbCO3 possesses an octahedral ligand structure. Part of the surface-active site is occupied, resulting in a change in the dissolution profile, and thus preventing further development of the dissolution profile. Ultimately, the entire dolomite surface area is prevented from dissolution. The results of this study suggest that Pb2+ may be an effective inhibitor of dolomite dissolution and may help to further refine the geological carbon sink.
Occurrence of helminth infections in the urban environment
Authors:   FSBEI HE Dagestan State Medical University of the Ministry of Health of Russia, Nurmagomedova S. G. , Trunova S. A. ,   FSBEI HE Dagestan State Medical University of the Ministry of Health of Russia, Magomedova U. A. ,   FSBEI HE Dagestan State Medical University of the Ministry of Health of Russia, Bartykhanova K. M. ,   FSBEI HE Dagestan State Medical University of the Ministry of Health of Russia, Adilkhanova D. B. ,   FSBEI HE Dagestan State Medical University of the Ministry of Health of Russia
Published: September 2022

Statistical studies indicate that there is a higher incidence of helminth infections in urban residents compared to rural dwellers. The problem of helminth infection remains relevant despite the growth in the standard of living of the population. In this article, the authors explain their point of view on helminth infection in an urban environment, which is more comfortable for human life. The study contains brief information about the most common diseases, their locations, ways of infection, and the severity of the diseases.
The application of dry garlic powder and humic feed additive Humiton to increase the efficiency of sturgeons stock material growing in aquaculture
Authors:   Siberian Research Institute of Agriculture and Peat — the Branch of Federal State Budgetary Scientific Institution of Siberian Federal Research Center of Agro-Bio Technologies of the Russian Academy of Sciences (Siberian Research Institute of Agriculture and Peat), Russia, Tomsk, Udintsev S.N. , Zhilyakovа T.P. ,   Siberian Research Institute of Agriculture and Peat — the Branch of Federal State Budgetary Scientific Institution of Siberian Federal Research Center of Agro-Bio Technologies of the Russian Academy of Sciences (Siberian Research Institute of Agriculture and Peat), Russia, Tomsk, Kinev G.V. ,   Tomsk research and production fish breeding complex, Russia, Tomsk
Published: September 2022

Restoring the population of relic fish sturgeons is a priority for international environmental protection measures. This problem is solved by mass production of fish fries in aquaculture for natural water bodies stocking. In this regard the effective technologies of production of such material is elevant. For this purpose the feeds for fries growing are enriches with additives of natural origin, which increase the viability and productivity of objects and have no negative impact on product quality and environment. As such additives, preparations based on food and medicinal plants — phytobiotics, as well as complex natural organic molecules — humic substances are used. In this experiment, Siberian sturgeon (Acipenser baerii Brandt, 1869) fries with an initial weight of 153.8±14.3 mg were fed with standard feed enriched with various doses of dry garlic powder as phytobiotic and humic feed additive Humiton. The inclusion of garlic powder at a dose of 30 g/kg and Humiton at the rate of 1 g/kg of humic acids to feed composition significantly increased the efficiency of fish rearing. After 5 weeks of experiment the survive of objects exceeded the control by 9.9%; the mass of fries was higher by 77.6% against the control and by 50% higher than the value of the calculated indicator of the factory juvenile sturgeons mass intended for stocking. The result obtained makes it possible to increase the efficiency of growing sturgeon fries in aquaculture in order to increase the mass and viability of the fish stock.
The use of new fish species in polyculture in fish farming
Authors:   Russian Research Institute of Integrated Fish Breeding — Branch of the Federal Science Center for Animal Husbandry named after academy Member L.K. Ernst, Russia, Moscow region, village named after Vorovsky, Servetnik G.E.
Published: September 2022

Increasing the potential productivity of biocenoses and their resistance to abiotic stresses, as well as increasing the productive and environmental functions of ecosystems, is also an urgent task. The main direction of development of the strategy of even carp farms is considered to be the presence of a much larger number of additional fish. In modern conditions, the most important means of increasing the fish productivity of ponds and natural reservoirs can be considered the expansion of the range of bred fish, taking into account the available feed base and the level of biotechnics. The traditional set of fish, which is recommended to be included in the polyculture of the north-western regions for the fullest use of the feed base, is represented by the following fish: planktophages (peled), benthophages (chir, pyjian, carp, etc.), predators (pike perch, pike, trout, etc.), phyto-, zooplanktophages (white amur and motley carp), in some cases herbivorous (white cupid). Depending on the specific conditions, these or other objects are preferable. For example, in the fertilized lakes of the north-west, the main species feeding in pelagial is considered to be pelage, but it is better that this zone is mastered by silver carp, which is also a filter of phytoplankton and detritus (they make up 80–90% of the food lump). It is better than peled to master the nectobentos of the Chudsky whitefish, muksun and hybrids of peled with chir. Along with whitefish, it is advisable to grow carp or crucian carp in shallow lakes. Depending on the composition of the native ichthyofauna, which plays an essential role in the biocenosis, a polyculture may consist of a less familiar set of fish. Reservoirs built on peat workings of low-lying swamps are quite suitable for growing fish in polyculture: carp, tench, white amur, mottled and white carp, golden and silver carp, pike, walleye and even under particularly favorable conditions — trout and whitefish.
THE PHYSICAL ESSENCE OF CONCRETE AND REINFORCED CONCRETE RESISTANCE FROM DISLOCATIONS TO CRACKS
Authors:   Southwestern State University, KOLCHUNOV VL.I.
Published: September 2022

The physical essence of resistance of concrete and reinforced concrete from dislocations, micro-cracks to macro-cracks and its experimental justification is investigated. For the "eight" structure of crystals of different materials (concrete and steel) a general model in the form of a sphere was developed. For it the summation of volume sectors, levels - radii from the matrix of sliding planes (including octahedral and pure shear) is written down. This uses an alternative to the theory of plasticity in the form of energy interpretation on the surface of the sphere and determining the integral of the mean square of the tangential stresses. It is important to obtain dislocations in the microcrack, angular and linear deformations, and displacements in a representative volume of the concrete cube. As the intensity increases, the deformation process proceeds already to the mainline cracks, where the double-concole elements of tension, compression, transverse shear and torsion (its internal parameters) are refined. Significant issues are the dilatation modulus and transverse coefficient, for which functions have been developed at the stages of the stress-strain state of concrete during the evolution of the transition from crack formation to main cracks. Concrete compression and tension diagrams for strain intensity or minimum pure shear use shear stresses. The fundamental difference of the stress diagram in the downward section is the use of the ultimate resistance of the concrete. Stress reduction in a material whose failure has a "tear-off" character is an unnatural phenomenon, and the limiting resistance of concrete at and reduction of prism strength at the i-th step is . The deformation pattern of concrete during the formation of earlier microcracks and then later main cracks is oriented along for compression or across the loading line for tensile force.
Guia para inovação
Authors: Bizeto Marcos Augusto , Silva Sylvia Maria Affonso
Published: September 2022

Material consultivo para inventores e inventoras da Unifesp que tenham como objetivo conhecer os procedimentos que norteiam ações da agência de inovação tecnológica e social da Universidade Federal de São Paulo.
Bioclimatologie et syntaxonomie des forêts de chêne vert (Quercus rotundifoliaLam.) du Dahra oriental dans la région de Tipaza (Algérie) / Bioclimatology and syntaxonomy of the Holm Oak forests (Quercus rotundifolia Lam.) of eastern Dahra in the Tipaza region (Algeria)
Authors: Bouzahar Chafika , Kadid Yamina , Siab-Farsi Badia , Bioret Frédéric , Boulenouar Yacine , Boubaker Zoubir
Published: September 2022

Le chêne vert Quercus rotundifolia Lam. est une espèce du bassin méditerranéen qui se développe essentiellement dans sa partie occidentale en général et en Afrique du Nord en particulier. Il présente une répartition altitudinale remarquable et une très large plasticité vis-à-vis des facteurs mésologiques, et se trouve surtout au niveau des étages mésoméditerranéen et supraméditerranéen, où il forme des structures sylvatiques en bioclimats humides et subhumides. Les végétations à chêne vert dans le mésoméditerranéen et le thermoméditerranéen ont été étudiées sur les massifs du Dahra oriental. Après avoir analysé les caractéristiques bioclimatiques, en utilisant les données bioclimatiques extraites de WorldClim et les paramètres de WBCS, une typologie phytosociologique a été élaborée. La corrélation entre les données bioclimatiques, les groupements végétaux obtenus et le facteur altitudinal a permis d’élaborer une classification écologique des étages de végétation de Quercus rotundifolia. Les résultats sont présentés et discutés en vue de leur intégration dans un prochain travail de phytosociologie dynamicocaténale du Dahra oriental.
The Role of Islamic Philanthropy Institutions in Realizing the 5th Core on Pancasila : The Role of Lazismu in Realizing The Values of Social Justice
Authors: Farhan, S.IP. Muhammad
Published: September 2022

Pancasila is our philosophy and guideline in nation and state. In realizing the values of Pancasila, it is very difficult because this nation is very large. Therefore, the State really needs help from civil society. Philanthropy is an activity to do good or give charity to others so as to bring prosperity to the community. A philanthropic activity is needed to flatten the welfare of the people. This paper contains the actions of one of the Islamic Philanthropy institutions namely Lazismu in combating poverty evenly throughout Indonesia. Lazismu is an Islamic Philanthropy organization under the auspices of Muhammadiyah. The institution is helping the government to realize social welfare as mandated by Pancasila. This paper uses qualitative methods and descriptive analysis. Lazismu's role in the distribution of people's welfare in its strategic programs is very helpful for the government. As a result, the Government and Lazismu along with other social movements can ground Pancasila values in Indonesia, especially the 5th principle
 
Analysis of Factors Affecting the Interest of Buying Muslim Consumers in Minimarket 212 Mart and Indomaret in Kecamatan Pagedangan Kabupaten Tangerang, Banten Province - Indonesia
Authors: Muklis Muklis , Masitoh Siti
Published: September 2022

This study aims to determine what factors influence consumer buying interest in minimarkets 212 Mart in Pagedangan and Indomaret in Pagedangan. The method used in this research is a quantitative method using the Analytical Hierarchy Process (AHP) model. The criteria used in this study are location, service, price, facilities and products. The sampling technique used in this research is purposive sampling technique which is carried out by distributing questionnaires to all consumers who have bought at 212 Mart in Pagedangan and Indomaret in Pagedangan as many as 96 respondents. The results showed that the results of the assessment of the level of importance of the criteria in consumer buying interest at the 212 Mart Pagedangan and Indomaret in Pagedangan minimarkets produced the following priority / weight scales: Product priority I (0.2897), priority II price (0.2896), Priority III location (0.1681) , Priority IV services (0.1320) and Priority V facilities (0.1206). from the results of the assessment of the level of alternative importance in consumer buying interest at the minimarkets 212 Mart in Pagedangan and Indomaret in Pagedangan produces the following priority / weight scales: Indomaret I Priority (0.6373) and 212 Mart (0.3627).
The Effect of E-Samsat Implementation, Tax Knowledge, Service Quality, and Tax Sactions on Motor Vehicle Tax payer Compliance in East Surabaya
Authors: Congda Lysia
Published: September 2022

One of the things that affects the taxpayer in carrying out his obligations as a good citizen is compliance in paying taxes. Taxpayer compliance is an important factor in realizing tax revenue targets. The higher the compliance of the taxpayer, the higher the tax revenue will increase, and vice versa. The questionnaire used in this study were 100 questionnaire with the determination of samples is using the method of accidental sampling. Data collection is done by questionnaire method. There are several research methods used to achieve this research objective including descriptive statistical analysis, validity test, rehabilitation test, classical assumption test (normality test, multicollinearity test, heteroskedasticity test), multiple linear regression analysis, and t test.The results of this study show that the application of E-Samsat and tax sanctions has a positive effect on the compliance of motor vehicle taxpayers in East Surabaya. While The Knowledge of Taxation, and Quality of Service has no effect on the compliance of east Surabaya motor vehicle taxpayers.
THE CONCEPT «AMERICAN DREAM»: DIACHRONIC ANALYSIS
Authors: Saifullina M.
Published: September 2022

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El ordenamiento territorial como elemento clave en la gestión integral de hábitat
Authors: Gargantini Daniela Mariana , Martinez Matilde María del Carmen
Published: September 2022

Política habitacional y política urbana se encuentran íntimamente relacionadas. La política habitacional depende de definiciones vinculadas al ordenamiento y desarrollo territorial, porque la naturaleza de la vivienda en su concepción integral, que la asemeja a la noción de hábitat, requiere su articulación con otros servicios y bienes urbanos para su apropiado funcionamiento; de la misma manera que los espacios habitacionales influyen en forma significativa en la disposición de las estructuras urbanas y territoriales.Frente al impulso dado a nivel nacional a las políticas de desarrollo territorial en el último bienio, y tomando como eje de estudio el proceso conducente a su definición y futura sanción, este artículo analiza desde un enfoque crítico y reuniendo aportes de diferentes referentes en la materia, los avances y aspectos aún no considerados en la Ley de ordenamiento territorial de la provincia de Santa Fe, a fin de avanzar hacia una política integral del hábitat en la provincia y sus gobiernos locales.
Tomas de tierras promovidas, loteos informales y proyectos de viviendas de interés social, en barrios del noroeste del Gran Buenos Aires
Authors: Dombroski Lucas Jordán
Published: September 2022

El presente artículo explora un proceso de tomas de tierras, entre 2011 y 2015, considerando las relaciones entre el entramado actoral y las formas urbanas que resultan, a los fines de iluminar las formas de construcción, uso y apropiación del espacio, y con ello dar cuenta del lugar que ocupó la vivienda en diferentes momentos. El análisis ilumina las estrategias y representaciones de un elenco heterogéneo de actores, sus modos de operar así como sus acuerdos, negociaciones y disputas en y por el territorio. Metodológicamente, se trató de un estudio de caso, que se reconstruyó recurriendo a documentos, entrevistas semiestruc­turadas y a la elaboración de cartografía analítica. Se entiende que revisar las formas territoriales suma nuevas aristas a las investigaciones sobre la problemática.
Rehabilitation Framework for HIV/AIDS Clients in the Public Health Field Practice of Nursing Students: A Case Study
Authors: Sukatemin  , Santosa Budi Joko , Zakirullah Zakirullah , Hardy Syaifoel
Published: September 2022

One of the phenomena of people living with HIV/AIDS in the rehabilitation phase in rural areas is that there is not enough space for them to get optimal rehabilitation services. The objective of this study was to provide a public health field practice framework for nursing students in the rehabilitation of people with HIV/AIDS. This research used a case study with a collective design. The primary data were taken from in-depth interviews of 3 informants. Secondary data was from reputable journals. Data processing was done by organizing, sorting, grouping, coding, marking, and categorizing based on specific groupings. The analysis used descriptive analysis. The study found three problems i.e. HIV/AIDS material is in the curriculum, public health field practice is held in semester 5, and no specific guidelines for public health practice programs on the rehabilitation of HIV/AIDS. This study recommended student interventions in the rehabilitation framework for people with HIV/AIDS referring to public health field practices based on the 2019 National Guidelines for HIV/AIDS Management.