bluuebunny/crossref_metadata_2025 huggingface dataset:
FUTURISTIC TRENDS IN DIABETIC FOOT CARE
Authors: Suri Dr. Sandeep , Maiya Prof. G Arun , Sharma Dr. Sanjay
Published: June 2024

Foot complications are common in individuals with diabetes. They can occur due to prolonged hyperglycemia damaging the nerves and blood vessels in the feet. Risk factors include peripheral neuropathy, peripheral vascular disease, ulcers, infections, and Charcot arthropathy. The following review provides an overview of advancements in the field of diabetic foot. Technology helps us diagnose potential complications before they even occur. Various advanced devices can assist in monitoring risk factors such as temperature, pressure, and moisture levels to ensure optimal conditions. Wearable sensor technology, advanced imaging techniques, genetic & molecular markers, thermographic cameras, vascular flow monitoring, hyperspectral imaging, and neuropathy-detecting devices are some tools used for diagnosis. Using artificial intelligence and machine learning technologies, healthcare providers can analyze large amounts of patient data, such as medical history, imaging, blood parameters, and pressure readings. This analysis can help predict the likelihood of complications such as ulceration or infection. The management comprises various prevention and treatment options to improve the condition and quality of life. Therapeutic devices such as VELOX® Care, Natrox® Oxygen wound therapy, Topical wound oxygen therapy, Laser, electrical stimulation, matrix rhythm therapy, and Extra corporal Shock Wave therapy benefit in facilitating wound healing and preventing neuropathic symptoms by improving oxygen profusion, microvascular circulation, and nerve regeneration. The major method of preventing or treating diabetic foot ulcers entails Off-loading techniques, including removable and non-removable devices to relieve and optimize the pressure over the foot during weight-bearing activities. Advanced wound dressing techniques involve removing dead tissue and creating a moist environment for wound healing. Also, integrated surgical treatment of diabetic foot wounds can achieve satisfactory clinical results. We aim to comprehend the underlying causes and mechanisms leading to the development of conditions. Hence, we can leverage the latest technological advances and apply them more effectively in diagnosing and treating diabetic foot care.
CURRENT AND FUTURE TRENDS OF ARTIFICIAL INTELLIGENCE IN ORAL MEDICINE & RADIOLOGY
Authors: Najmuddin Dr. Mohammed , Saheb Dr. Safeena Abdul Khader
Published: June 2024

Introduction: Artificial Intelligence (AI) is referred as a branch of computer science which is customized to build up computer algorithms to do the works which are basically based on intelligence of human beings, like capability to understand and manage the tasks. Word "AI" is being utilized when computer manages to do some analytical tasks like "problem-solving and learning", that generally a man usually connect with brains of other human beings. This branch helps in planning diagnosis, decisions for projection, treatment and prognosis. AI is shown to uplift the efficiency, accuracy and precision similar to medical practitioners, but comparatively more fast and affordably. Materials and Method: The sources were searched from a database of PubMed library and Google Scholar for published literature from 2017 to 2023 (last 6 years). The inclusion criteria included key words of AI, recent trends in dentistry, applications of AI, Results: The 17 articles that met the selection criteria (most of them were review article and some observational studies) were included for this chapter. Conclusion: AI has become a promising tool by its various applications in dentistry. Although it cannot replace the role of dentists in health care system, but it can prove as a valuable adjunct by assisting in diagnosis and treatment planning in a fast and precise way. Still there is the need to understand the models and concepts of AI clearly in order to get proper benefits of this technology. To establish AI databases, dentists should also provide authenticated information, so that accurate results can be received from AI. The challenges should be managed in such a way that dentists can have a long-term reliability on AI models.
CURRENT & FUTURE TRENDS OF AI IN DENTAL RADIOLOGY
Authors: Shahbaz Dr. Syed
Published: June 2024

Artificial intelligence (AI) is described as "a branch of science and engineering focused on computationally comprehending what is commonly referred to as intelligent behavior and producing artifacts that demonstrate such behaviour". Artificial intelligence was once considered a distant and fantastical dream for the future, but it has progressively transformed into a tangible reality across various industries, including the dental and medical sectors. Notably, artificial intelligence has found recent applications in the domain of dentistry, particularly in the field of oral and maxillofacial (OMF) radiology, where it is employed to analyse radiographic images. This chapter intends to highlight the current and future trends of AI in Dental Radiology.
RECENT TRENDS IN ROOT CANAL IRRIGANT ACTIVATION DEVICES
Authors: P.S Dr. Pavitra , P Dr. Jayakrishnan , Narayanan Dr K Sathya , Shivanna Dr. Sushmita
Published: June 2024

According to contemporary standards in dentistry, the core focus of endodontic treatment revolves around achieving thorough chemo-mechanical disinfection of the root canal system. Integral to this procedure is the irrigation of the canals using specific solutions, coupled with the activation of these solutions. This chapter aims to consolidate and compare a range of techniques used to activate irrigants during endodontic treatment, including manual activation, sonic agitation, ultrasonic activation, pressure-based techniques, and laser-based approaches.
FORMULATION AND SHELF-LIFE ASSESSMENT OF WATERMELON (CITRULLUS LANATUS) SEEDS CHIKKI
Authors: V Sujitha , L Uthira , V Padmapriya
Published: June 2024

Food production and consumption generate a significant amount of processing waste, with fruit waste accounting for a large portion. Cucurbits with thick rinds, such as watermelons, musk melons, and pumpkins, produce large amounts of waste during their consumption. However, using natural 'food waste,' such as seeds and peels, which are high in vital nutrients, is being promoted as a long-term solution to food insecurity. Watermelon seeds was chosen for this study because they are the most discarded fruit seed. The procured watermelon seed was analysed for its proximate composition which is composed of good amounts of protein and fat (28.3g and 47.2g/100g). Three different varieties of Chikkis were made from watermelon seeds, but Variation II is the one used for the proximate analysis of Chikkis because it had the highest mean score during the organoleptic evaluation. The carbohydrate and protein contents of the watermelon seed Chikkis were 52.5g and 14.1g per 100g respectively. Chikkis were packed in an air tight container and stored at room temperature to evaluate moisture loss or gain over a period of 50 days. Overall, the results suggest that the utilization and consumption of watermelon seeds can promote and preserve health and the use of watermelon seeds for consumption will be a step forward for sustainable development to reduce food waste.
ARTIFICIAL INTELLIGENCE AND MACHINE LEARNING ENABLED MEDICAL DEVICES
Authors: Ingawale Dr Sushrut , Chheda Dr Mahek
Published: June 2024

The chapter delves into the dynamic convergence of AI and ML with healthcare technologies, elucidating their transformative impact on diagnostics, treatment, and patient care. Expounding upon the history of both AI and medical devices, the chapter highlights their integration, exemplifying applications across radiology, pathology, prosthetics, drug delivery, and more. From automated image interpretation and AI-assisted diagnoses to wearable health monitoring and telehealth platforms, the article illuminates diverse AI-driven innovations. The discussion accentuates ethical considerations, regulatory frameworks, and challenges such as bias mitigation and physician acceptance. Amidst the promises of enhanced personalized medicine and early disease detection, the chapter underscores the necessity of interdisciplinary research, collaboration, and responsible implementation to fully harness the potential of AI and ML-enabled medical devices, ultimately shaping a future where technology synergizes with healthcare for improved patient outcomes and a redefined medical landscape.
FROM IOT TO IOS: UNDERSTANDING THE THEORETICAL FRAMEWORK OF THE INTERNET OF SENSES
Authors: S Jeevakumar , D. C Christo Melbin
Published: June 2024

Advancements in technology by 2030 are poised to enable brain-to-device interfaces, making traditional input methods obsolete. Users will control digital devices through thought commands, eliminating the need for keyboards, mouses, and touch screens. AR glasses are expected to offer seamless information access, responding to thought requests. The interconnected nature of technology and human thoughts could lead to thought-based communication, allowing users to share information with others. However, concerns about privacy arise, with users wanting to keep thought data secure from advertisers and external access. Around half of consumers predict that minds will be essentially connected by 2030, enabling thought communication and sharing with loved ones. The shift prompts questions about the future business model as data privacy becomes paramount in a world where thoughts can be accessed and potentially monetized. Careful consideration is needed to preserve privacy and user trust in this transformative future.
THE SURGE OF ARTIFICIAL INTELLIGENCE IN HEALTHCARE SECTOR
Authors: Kaur Dr. Harpreet , Garg Dr. Ruchika , Singh Dr. Jagseer
Published: June 2024

Artificial intelligence (AI) is making intelligent machines for the purpose of solving the problems and tasks by combining various subfields like machine learning (ML) and deep learning (DL). AI has diverse applications in each branch of science. It solves the problem of understanding, replicating intelligence and cognitive processes. AI is also playing a crucial role in new drug discoveries and management of medical data. It improves the accuracy of health care analysis. Recently applications of AI in the healthcare sector have been increased with several advantages and some limitations.
ANALYTICAL QBD APPROACH TO HPLC METHOD DEVELOPMENT AND VALIDATION FOR PREGABALIN
Authors: K Shah Chandra , Zarna Dr. Dedania , Ronak Dr. Dedania , C Dr. Jain Vineet
Published: June 2024

Analytical QbD helps to provideanalytical life cycle management by systemic method development and maintenance. An efficient CCD - Central Composite Design was developed at 23 factorial designs; mobile phase composition and pH kept as two different factors at law(-1), medium(0) and high(+1) at three levels for RP-HPLC method. The response to be evaluated being retention time, peak asymmetry and theoretical plates. The chromatographic separation conditions were optimized with the Design Expert Software version10.0.1.0, i.e. Inertsil ODS column C18 (250×4.6mm, 5.0µm), mobile phase used werephosphate buffer: methanol: acetonitrile (92:5:3, v/v/v) adjusted to pH 5. The flow rate was set 1.2 ml/min and210 nm was set as detection wavelength with PDA detector.The above chromatographic condition for elution, Pregabalin was found to beeluted at 6.083 min of retention time. The linearity of developed RP-HPLC method was from 200-1000 µg/ml with r2 = 0.9992.The system suitability parameters were; 0.916 as value of tailing factor and 4238 as value of theoretical plates. The % RSD for inter day and intraday precision with 0.0112-0.0225 and 0.0058- 0.0182 respectively. The %RSD forprecision and robustness values were observed less than 2% indicate the preciseness of developed method. The assay results from pharmaceutical dosage form with 100.01 ± 0.72 %w/w. The chromatographic peak purity indicate only pregabalin peak at observed retention time and any other peaks were absent.The results of all the validation parameters were as per ICH guidelines within the acceptance criteria.This experiment provides a better knowledge of the parameters that improve chromatographic separation with more dependence on the capabilities of the created HPLC technique to meet their intended demand.It gives practical information understanding that aids in the construction of chromatographic optimization for future application. The QbD technique of method development has aided in the understanding of method variables, lowering the probability of failure during method validation and transfer.
EMERGING TRENDS IN GLOBAL HR
Authors: Joyce Dr. P. Rockeny
Published: June 2024

Since the epidemic, the future of HR has radically changed. With the emergence of generative AI, remote working, AR/VR, metaverse, and other technologies, the HR profession will radically change into a crucial component of the workplace. The change in HR workings will also have an impact on the future of work itself. To adapt to the times, the HR function is undergoing metamorphosis. HRM professionals have their work cut out for them, from the requirement to regularly update rules and procedures to the difficulty of managing a remote workforce. These issues may be properly and efficiently handled with the right approaches and solutions, allowing businesses to continue to operate profitably and productively. Therefore In this Paper, we'll examine the emerging trends that will be faced by HRM Professionals, and suggest solutions.
IOT & SMART HOME SYSTEM: A NEW WAY OF MANAGEMENT
Authors: Pingale Mrs. Sushma M.
Published: June 2024

A smart home system makes our life quite easy. We can monitor and control our household devices or home appliances remotely. The Internet of Things (IOT) is a network of different physical devices, vehicles, and appliances that are embedded with sensors, software, and network connectivity and it allows them to collect and share data. A smart home system is a major application of IOT. This paper represents the integration of IOT technologies with smart home systems to ease home automation tasks. Also discusses various problems and challenges in IOT and home automation systems.
MANAGING INFORMATION TECHNOLOGY RISKS IN BUSINESS
Authors: Chowdhury Dr. Subhasish Roy
Published: June 2024

New incidents of cyber-attacks often come up in the news where an organisation’s technological security infra web is compromised leading to loss and malafide use of confidential data. With the proliferation of such incidents at a high rate, it is pertinent and much wiser to assess the risk and volatility which exist in the domain of information technology, constantly and uninterruptedly with the help of a robust ‘Information Technology Risk Management Framework’. Such a framework should possess enough intelligence to spot and predict the risks proactively and apply ‘firewalls’ to resist such risk from attacking the techno infra as well as apply adequate and faster healer to the already assaulted techno infra and salvage it within no time lost.
FUTURISTIC TRENDS IN MANAGEMENT: REVOLUTIONIZING THE VIRTUAL CRYPTOCURRENCY AND INVESTMENT MARKET
Authors: Malaji Prashant Ganesh
Published: June 2024

In this ever-evolving world, the virtual market and cryptocurrency investment have become integral parts of our daily lsives. The global community has wholeheartedly embraced virtual activities, and an increasing number of individuals are connected to online networks, leveraging these platforms for both learning and earning opportunities. The convenience and accessibility of online networks have revolutionized how people connect with one another and manage their financial endeavours. Through these virtual platforms, individuals can explore various financial avenues and discover ways to earn money effectively. In this digital landscape, the online platform serves as an empowering tool, providing valuable financial insights and enabling users to seize opportunities in the cryptocurrency market. As a result, individuals can navigate this dynamic environment with greater ease and confidence, harnessing the potential of virtual technologies to secure their financial future.
ONLINE GAMING MANAGEMENT PLATFORM
Authors: Vishal Shrivastava Dr. , Sangeeta Sharma ER. , Mishra Saumya , Akhil Pandey Dr.
Published: June 2024

Online gaming management system in India is vast and growing rapidly, as the country has a large and growing population of gamers and a thriving gaming industry. But even though gamers and organizers do not have a single solution to build out the tournament along with the management. This provides single stage gamers data, Brands can avail trust through the platform, Digital content broadcasting and posting platform engagement and less human resources are utilized. To effectively plan, organize, and execute online gaming events that meet the needs and expectations of all organizers, gamers, and sponsors .While ensuring a positive return on investment and minimizing risk and Challenges. Lack of online gaming management platform, Lack of exposure and event aggregation, Lack of flexible data reporting system.
A REVIEW ON DIFFERENT MACHINE LEARNING ALGORITHMS TO BREAST CANCER RISK PREDICTION
Authors: Buri Ram Babu , Vishal Shrivastav Dr.
Published: June 2024

Breast cancer is the second most fatal kind of cancer in women, accounting for almost a quarter of all cancer deaths. About 10 percent of women worldwide are diagnosed with breast cancer at some time in their lives, making it one of the most frequent malignancies among women today. However, although the treatment for this cancer is now accessible in practically all first world and some third world countries, the primary problem occurs when the cancer is not appropriately detected at the very beginning of the disease's progression. Several researchers have made significant contributions to early diagnosis, improved prognosis, and better treatment of BC during the previous two decades, resulting in a decrease in the death rate. Machine Learning has shown to be quite useful in this discipline, particularly in the prediction of illnesses such as cancer. So far, classification and data mining approaches have shown to be dependable and successful means of categorizing data. These strategies have been used to forecast and make judgments in a variety of fields, particularly the medical industry. Throughout this study, we examined the current state of the art in BC prediction, which included breast cancer diagnosis, BC risk prediction using several machine learning algorithms, and breast cancer recurrence prediction.
PHARMACODYNAMICS
Authors: Rupam Supreet
Published: June 2024

Pharmacodynamics deals with the effect of drugs on different body systems and includes mechanism of action of drugs. When choosing the right molecules, evaluating the safety and effectiveness of therapeutic candidates, and creating the best clinical dosage regimens, it is essential to evaluate drug exposure as well as responses. Numerous factors, including those that are biological, psychological, genetic, pathological, environmental, and pharmacological, can alter how a drug acts, impacting every step from the prescription of the drug to the effects it has on the patient. If any of these conditions apply to a person, the medicine choice and dosage must be altered.
MANAGEMENT IN HEALTHCARE: STRATEGIES FOR SUCCESS
Authors: Venus Thakur Ms.
Published: June 2024

Effective administration is essential in the healthcare industry, where high-quality patient care, cost control, and efficient resource allocation are of the utmost importance. It includes planning, organising, staffing, directing, and regulating, the primary functions of healthcare management. To meet the diverse requirements of patients, healthcare providers, and other stakeholders, planning involves establishing strategic goals, developing policies, and designing operational frameworks. Organising involves structuring the healthcare organisation, establishing communication channels, and coordinating resources to ensure efficient operations. The staffing focuses on recruiting, training, and retaining qualified healthcare professionals, whereas directing requires leadership and guiding teams to achieve organisational objectives. Controlling involves monitoring performance, evaluating results, and implementing corrective measures to ensure quality improvement. It highlights the significance of evidence-based practises, quality improvement initiatives, and patient safety measures for improving clinical outcomes. In healthcare organisations, effective management contributes to streamlining processes, reducing medical errors, and nurturing a culture of continuous learning and improvement. Effective management is crucial for the success of healthcare organisations in meeting the demands of a swiftly changing healthcare environment. It emphasises the incorporation of health information systems, electronic health records, telemedicine, and data analytics in order to improve operational efficiency, facilitate evidence-based decision making, and increase patient engagement. Healthcare managers can create positive change and shape the future of healthcare delivery by embracing innovative approaches and leveraging technology.
A REVIEW ON SUPPOSITORIES
Authors: Bhaskar Jimidi Dr.
Published: June 2024

Suppositories are semisolid dose forms of medication intended for insertion into cavities of the body other than the mouth. They can be placed into the vagina, ear, nose, or rectum. To release the medication, they will either melt or dissolve in the bodily fluid.
ETHICAL AND PROFESSIONAL ISSUE IN NURSING
Authors: Solomon Alfred
Published: June 2024

Ethics is a crucial aspect of nursing, as it involves understanding one's own thoughts and societal perceptions of appropriate behavior. Nursing professionals often deal with clinical dilemmas with patients and decisions regarding specific diseases and treatments. The majority of ethical issues in the field of nursing center on human rights or direct client care issues. A profession with a strong foundation in moral principles and professional ethics is nursing, which includes principles such as human dignity, integrity, altruism, and justice. The nurse-patient relationship is a key idea in nursing theory and practice, focusing on human interactions, excellent communication skills, and mutual cooperation. Nurses must create and maint125-132ain a therapeutic nurse-patient relationship, which should be collaborative and patient-centered. This relationship requires nurses to support the patient's ability to survive and recover from illness, foster their independence, and, in cases of terminal illness, lessen physical symptoms like pain and foster dignity. Patients believe that the nurse-patient relationship is just as valuable as other clinical interventions, and establishing this kind of helpful relationship requires nurses to be accessible, spend enough time with them, and pay close attention to verbal outcomes. Critical reflection on various subjects, such as the function of a nurse, the appropriate interpersonal behaviors, and the moral qualities nurses should exhibit when providing nursing care, is necessary for high-quality nursing care to be provided. These are character traits, or more precisely, moral virtues. There are several ethical principles in nursing, autonomy, beneficence, non-maleficence, justice, veracity, and justice. In conclusion, ethical principles in nursing include autonomy, beneficence, justice, veracity, honesty, and truthfulness. By understanding these principles and applying them in practice, nurses can provide high-quality care to their patients and uphold the highest standards of ethical conduct in the field.
REVIEW ARTICLE ON NUCLEAR MEDICINE
Authors: Harsha. K. Donde Ms. , Archana. D. Kahar Ms. , Sachin B. Somwanshi Dr.
Published: June 2024

Over the course of decades, the field of nuclear medicine (NM) has undergone both progressive and dramatic developments, owing primarily to responsive and flexible shifts in the global manufacturing and utilization of radiation therapies (RPh), as well as the development of new technology. Imaging devices capable of characterizing pictures, such as single-photon emission computed tomography/computed tomography [CT], positron emission scanning [PET]/CT, and PET/magnetic response. Naturally, as the NMRPh progresses, many critical lessons are acquired along the road. To ensure effective communication with the referral medical community and health services officials, it is felt necessary for the NM-RPh belonging to have a list(s) of indications for NM, classified on the basis of value levels, at the NM coarse level as well as medical specialty-wise, and related value levels.
INTRODUCTION OF PHARMACOTHERAPEUTICS
Authors: Pankaj Mishra Dr. , Varsha Saini Ms.
Published: June 2024

Pharmacotherapeutics may be defined as a branch of pharmacology that deals with the therapeutic uses and effects of drugs. The main objective of Pharmacotherapeutics is too hence the safety of prescription maximum of the drug & minimum side effects. Importance of Pharmacotherapeutics when diagnosis the disease the provided the right treatment. It summarizes the possible therapeutic approach in disease management. Pharmacotherapeutics encompasses the use of Pharmacotherapeutics products such as drugs, vaccines or therapeutic devices, to cure, control or prevent disease or to maintain health.
PHARMACOLOGICAL EFFECT OF DESMODIUM GANGETICUM L. AS A BRONCHODILATOR
Authors: Kumar Santosh , Pal Deepika , Chetna Ms. , Aparadh Vasim Mansur
Published: June 2024

Desmodiumgangeticum L., commonly known as "Salparni" or "Gangetic Bedstraw," is a medicinal plant with a long history of use in traditional medicine systems, particularly in Ayurveda. Among its numerous therapeutic properties, one of the most notable is its bronchodilator effect. Bronchodilators are substances that relax and widen the airways in the lungs, providing relief to individuals suffering from respiratory conditions characterized by bronchoconstriction. This abstract presents a comprehensive review of the pharmacological effects of Desmodiumgangeticum as a bronchodilator. The bronchodilatory activity of this plant is attributed to its diverse phytochemical composition, with alkaloids, particularly vasicine and vasicinone, being the primary bioactive constituents responsible for the relaxant effect on bronchial smooth muscles. Experimental evidence from in vitro studies on isolated airway tissues and in vivo animal models supports the bronchodilatory activity of Desmodiumgangeticum. The plant's active compounds have demonstrated the ability to inhibit bronchoconstrictor responses induced by acetylcholine and histamine, suggesting its potential in preventing or alleviating bronchoconstriction. Moreover, Desmodiumgangeticum exhibits anti-inflammatory and antioxidant properties, which further contribute to its therapeutic potential in respiratory conditions. Its ability to reduce pro-inflammatory cytokines and neutralize reactive oxygen species may help in mitigating airway inflammation and oxidative stress, both of which are key factors in respiratory disease pathogenesis. While the experimental evidence is promising, human clinical trials are essential to establish the safety and efficacy of Desmodiumgangeticum as a bronchodilator in real-life settings. Preliminary clinical studies and case reports have demonstrated potential benefits in improving lung function and reducing respiratory symptoms in individuals with asthma and chronic obstructive pulmonary disease (COPD). In conclusion, Desmodiumgangeticum L. holds significant potential as a natural bronchodilator due to its diverse pharmacological effects. Further research, particularly human clinical trials, is warranted to validate its efficacy and safety, and to determine its optimal therapeutic applications in the management of respiratory diseases. As the interest in herbal medicine and natural remedies continues to grow, this ancient medicinal plant may offer a promising solution for respiratory conditions and could potentially complement existing therapeutic approaches.
MUCOADHESIVE OCULAR NANOFORMULATIONS: ADVANCEMENTS IN DRUG DELIVERY FOR IMPROVED OCULAR THERAPY
Authors: Maheshwari Shubhrat , Kumar Ajeet , Sharma Shubham , Dutta Sayantan , Yadav Jagat Pal , Pandey Sonia
Published: June 2024

Ocular drug delivery poses a significant challenge due to the intricate structure and protective barriers present in the eye. Traditional techniques, including systemic administration and topical eye drops, often have limited therapeutic efficacy and poor bioavailability. However, the emergence of mucoadhesive ocular nanoparticles has the potential to revolutionize ocular drug delivery by overcoming these challenges. Eye drops remain a popular non-invasive method of treating ocular ailments. Nevertheless, conventional eye drop formulations are associated with several limitations, such as rapid drainage from the eye, low bioavailability, and frequent administrations. Mucoadhesive nanoparticles present a promising solution to address these issues by enhancing drug retention and permeation in the eye. This chapter offers a comprehensive overview of recent developments in mucoadhesive ocular nanoparticles and their implications for ocular drug delivery. It discusses the anatomy and protective barriers of the eye that influence drug penetration and the need for innovative drug delivery systems. The chapter explores various natural and synthetic mucoadhesive polymers used in nanoparticle formulations and their interactions with ocular tissues. Additionally, it highlights the development and characterization of nanosystems, including micelles, liposomes, nanosuspensions, and nanogels, that incorporate mucoadhesive properties to enhance ocular drug delivery. The potential applications of mucoadhesive ocular nanoparticles in addressing ocular diseases affecting both the anterior and posterior segments are discussed. Furthermore, the chapter emphasizes the importance of understanding the anatomical and physiological challenges in ocular drug delivery to design effective and safe drug delivery systems. Overall, this book chapter serves as a valuable resource for researchers, scientists, and pharmaceutical experts working in the field of ocular drug delivery. It provides insights into the recent advancements in mucoadhesive ocular nanoparticles and their potential implications in improving therapeutic outcomes and patient compliance for various ocular disorders.
NATURAL MEDICINE IN DENTAL HYGIENE AND ASSOCIATED COMPLICATIONS
Authors: Srivastava Pragya , Patil Dinesh Prabhakar , Yadav Mandeep , Yadav Savisa
Published: June 2024

The integration of natural medicine into dental hygiene practices has garnered increasing attention due to its potential to offer effective, holistic approaches to maintaining oral health and managing associated complications. Natural products, derived from plants and other sources, possess a diverse array of bioactive compounds that contribute to antimicrobial, anti-inflammatory, and wound-healing properties. These substances, such as xylitol, propolis, and herbal extracts, play a pivotal role in preventing tooth decay, reducing plaque formation, and combating gum disease. Moreover, the antioxidant and immune-stimulating qualities found in various natural ingredients aid in promoting tissue healing and bolstering the body's defense mechanisms. Natural medicine also emphasizes a patient-centered approach, focusing on individualized care and preventive strategies. The use of phytoconstituents like curcumin, resveratrol, and quercetin showcases their potential to mitigate inflammation, combat pathogens, and support overall oral health. However, the integration of natural medicine into dental hygiene requires careful consideration, informed by evidence-based practices and professional guidance. As an emerging field, natural medicine in dental care holds promise in expanding our understanding of comprehensive oral health management while respecting the principles of sustainable and integrative healthcare.
PRIMASES: A POTENTIAL DRUG TARGET A BRIEF SUMMARY
Authors: Rai Dr. Praveen
Published: June 2024

DNA primases are more than just RNA primer makers for DNA replication. Primase has been classified into two types, one in DnaG and the other one isthe archaeo-eukaryotic primase (AEP) superfamily, which has many functions in different domains of life. AEPs can act as primase-polymerases, which can synthesize both RNA and DNA, and participate in various DNA processes, such as damage tolerance and repair. AEPs are diverse and multifunctional enzymes that deserve a new classification and more attention. Here in this book chapter, a brief discussion about both families with an example of drug targets.
AN ASSESSMENT OF DIFFERENT DIETARY APPROACHES FOR THE MANAGEMENT OF DIABETES
Authors: Ali Dr. Asghar , Garg Manika , Sharma Riya , Sarita Ms. , Firdaus Ruhi , Noorani Dr. Md Salik
Published: June 2024

Diabetes is a prevalent chronic condition necessitating effective dietary interventions for management. This chapter explores the efficacy of different dietary approaches, with a specific focus on low-carbohydrate and plant-based diets, in managing diabetes. Research indicates that both dietary approaches contribute to improved glycemic control and overall health outcomes in individuals with diabetes. Low-carbohydrate diets exhibit particular effectiveness in reducing blood sugar levels, while plant-based diets demonstrate the potential to enhance insulin sensitivity and reduce cardiovascular disease risk. Nevertheless, potential drawbacks include nutrient deficiencies in plant-based diets and high saturated fat intake in low-carbohydrate diets. Further research is essential to determine the optimal dietary strategies for diabetes management and to develop effective strategies to promote long-term adherence to healthy dietary habits among individuals with diabetes.
ITRAQ: A PROTEOMIC APPROACH FOR QUANTIFICATION OF PROTEIN AND DATA ANALYSIS
Authors: Lakhanil Komal G , Gupta Sheetal , Dwivedi Aditi , Marviya G. V.
Published: June 2024

Proteins are large, complex molecules and are considered the basis of life as they perform a wide range of functions in living organisms, including structural support, enzymatic catalysis, signalling, and regulation of gene expression. Proteomics, a branch of molecular biology, helps understand the comprehensive analysis of proteins, particularly their structures, functions, interactions, and abundances within a biological system. Over the years, several quantitative proteomic methods have been developed to measure protein abundances and compare protein expression levels between different conditions or samples. This facilitated studying dynamic changes in the proteome in response to various stimuli. Isobaric Tags for Relative and Absolute Quantification (iTRAQ) is a groundbreaking technique that has revolutionized proteomic research. iTRAQ is a bottom-up approach and shotgun-based quantitation technique that enables simultaneous identification and relative quantification of hundreds of proteins in up to eight different biological samples in a single experiment using mass spectrometry. This book chapter aims to provide a comprehensive overview of the iTRAQ technique, highlighting its principles, experimental workflow, data analysis strategies, and applications in various fields.
BIOREMEDIATION: HARNESSING NATURE'S POWER FOR ENVIRONMENTAL CLEANUP
Authors: Bajaj Mr. Gokul S.
Published: June 2024

The growing rate of urbanization and industrialization has led to an increase in several types of pollution caused by the release of toxic chemicals to the environment. This is usually perpetuated by the manufacturing industry (e.g. detergent and dye), agricultural sectors (e.g. fertilizers and pesticides), mining industry (e.g. cyanide and sulphuric acid) and construction companies (e.g. cement and metals). Bioremediation is an effective cleaning technique for removing toxic waste from polluted environments that is gaining popularity. Various microorganisms, including aerobes and anaerobes, are used in bioremediation to treat contaminated sites. Microorganisms play a major role in bioremediation, given that it is a process in which hazardous wastes and pollutants are eliminated, degraded, detoxified, and immobilized. Pollutants are degraded and converted to less toxic forms, which is a primary goal of bioremediation. Ex situ or in situ bioremediation can be used, depending on a variety of factors, such as cost, pollutant types, and concentration. As a result, a suitable bioremediation method has been chosen.
DE NOVO DRUG DESIGNING FOR INFLUENZA A VIRUS H11N9, LEAD FOR NEURAMINIDASE INHIBITORS
Authors: Tomer Archana , Vats Vishnu , Kumar Pravita , Kumar Yogendra , Sarkar Anjana
Published: June 2024

The study highlights the effectiveness of computer-aided de novo drug design, in swiftly and reliably generating novel target-specific drugs or lead-like molecules through in silico techniques. Using the e-Lea3D de novo design platform, a set of 20 distinct stereoisomers exhibiting drug/lead-like attributes were meticulously crafted within the protein's core. Emphasis was directed toward the de novo-generated molecules showcasing superior plant scores relative to their corresponding stereoisomers. Of 20 molecules 3 molecules were selected on the basis of high scores. Subsequent docking analyses of three selected molecules guided by the e-Lea3D outputs underscored the significance of these findings. These results hold immense promise for the advancement of potential neuraminidase inhibitors, presenting a pathway toward developing compounds with enhanced therapeutic potential.
THE PIVOTAL ROLE OF INSTRUMENTATION AND MEASUREMENT IN BIOTECHNOLOGY
Authors: Eswaran Dr. Ushaa , Eswaran Vivek , Murali Keerthna , Eswaran Vishal
Published: June 2024

Instrumentation and measurement techniques play a pivotal role in the advancement of biotechnology. This chapter explores the critical importance of tools like sensors and analyzers in enabling key applications, driving scientific discoveries, and catalyzing innovation across the biotechnology domain. Beginning with an overview of how real-time monitoring and precision measurements empower optimized bioprocesses and medical diagnostics, the narrative delves into the diverse landscape of sensor technologies for detecting biomolecules and environmental factors. Recent sensor advances have enabled enhanced accuracy, sensitivity, and real-time analysis, fueling progress in areas from medical diagnostics to environmental monitoring. The significance of precision in experimental measurements and data analysis is also discussed in relation to reproducibility, interpretation of biological phenomena, and convergence with emerging technologies. Additionally, the chapter traces the exponential trajectory of biotechnological progress enabled by advances in instrumentation like high-throughput sequencing, single cell analysis, and omics technologies. These innovations have unlocked new capabilities for unraveling genetic diversity, cellular heterogeneity, and molecular-level insights. The chapter concludes with a look at emerging trends in instrumentation that continue to transform real-time data collection and analytics across industries through integration of technologies like IoT, AI, and nanomaterials. Overall, the symbiotic relationship between biotechnology and cutting-edge instrumentation is highlighted as a key driver of scientific discoveries, therapeutic breakthroughs, and advanced analytical capabilities.
AN INSIGHT OF METAL OXIDE-BASED PHOSPHORMATERIALS AND THEIR APPLICATIONS
Authors: Sehrawat Supriya , Duhan Surender , Priya Ms.
Published: June 2024

Phosphor is a general term used for mainly such inorganic materials which have capability to exhibit luminescent properties by emitting the absorbed light in visible region mostly. When a radiation either present in electromagnetic spectrum or a beam of electrons as well as photons is imparted on the powdered surface of phosphors material, there is emission of light mainly in visible region, which further corresponds to various characteristic colours exhibiting phosphors. We can also assume phosphors materials to be working on the principle of same as that of transducer because of the phenomenon of conversion of one form of energy into another while emanating the light in mainly visible region. On the basis of usage of different source radiation for the excitation of phosphors materials, they can be classified into various categories such as photoluminescence, cathodoluminescence, electroluminescence, triboluminescence, X-ray luminescence, andchemo luminescence. In recent decades, there have been immense research on the metal oxide doped phosphors due to significant increased stability and comparatively very smooth synthetization process having great practical applicability in various fields. Further the principle of luminescence, which is, mainly based on excitation of valence electrons present in d and f orbitals of valence shell of metal oxide doped phosphors, will be discussed in details in this chapter. There are various characterization techniques that are used for the investigation and analysis of metal-oxide based phosphors such as Thermogravimetric/Differential Thermal Analysis (TG/DTA), Fourier Transform Infra-red (FTIR), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy, Photoluminescence spectroscopy along with Phonon Side Band Analysis, and Colorimetry, UV-Vis-NIR spectroscopy, Raman spectroscopy, X-ray Photoelectron spectroscopy and z-scan technique, are briefly discussed in the chapter. Finally, this chapter accounts briefly the various practical applications of metal oxide-based phosphors as light emitting diodes, LEDs, fluorescent lamps, cathode ray tubes, safety indicators, plasma displays etc.
EFFECT OF COATING ON DIFFERENT COMPONENTS OF THE LITHIUM BATTERIES FOR ENERGY STORAGE
Authors: Sachdev Devyanshu , Bhullar Navneet Kaur , Kumari Kamlesh
Published: June 2024

Energy storage has grown into a key area of research for both industry and academia in recent times, as the energy issue has gotten worse. Surface coatings play a significant role in the energy storage of various types including chemical, electrochemical, electrical, mechanical and thermal energy. Surface coatings are barriers that are artificial often comprised of electrochemically active or inactive coating materials, placed to the surfaces of different components of lithium ion batteries (LIBs) to provide a better electrochemical performance of the materials by limiting the potentially damaging side reactions. The selection of the right coating material and thickness is crucial which helps in improving different characteristics of the different components of batteries. By expanding the surface area, coatings also assist in improving the efficiency of storage systems. It is possible to incorporate coating materials directly into substrates without the need for further morphological deformations. This chapter focuses on the effect of coating on the different components of LIBs and its usage for energy storage.
STUDIES ON PHYSICOCHEMICAL PARAMETERS AND USE OF NATURAL COAGULANTS FOR WASTE WATER TREATMENT IN INDUSTRIAL AREA OF MAHASAMUND DISTRICT, CHHATTISGARH (INDIA)
Authors: Patel Anjali , Choubey Sonal
Published: June 2024

Turbidity is an accomplished challenge in water treatment. Moringa oleifera and Dolichos lablab were applied as locally accessible congenital coagulants in this reverie to break the turbidity of artificial water. After dosing, water-accountable extracts of Moringa oleifera and Dolichos lablab busted turbidity to 6.1 and 11.8 NTU, singly, from 100 NTU and 5.2 and 9.3 NTU, after dosing and filtration. Among the natural coagulants applied in this trance for turbidity abatement, Moringa oleifera was set up most effectual. It degraded up to 94.8% turbidity of the raw, muddy water. Natural coagulants answered better with altitudinous, muddy, water analogized to average muddy, water. Applying locally accessible natural coagulants, capable, effortless, and terrain- close accessories for water treatment were obeyed.
คลังปัญญาจุฬาฯ ขอระงับการเผยแพร่ทรัพยากรรายการนี้
Authors:   , suppressed temporarily
Published: June 2024

คลังปัญญาจุฬาฯ ขอระงับการเผยแพร่ทรัพยากรรายการนี้
Detection of hydrogen peroxide and persulfate ion by gold nanorod sensor
Authors:   , Chunnuan Petrada
Published: June 2024

Gold nanorods (GNRs) multicolor sensor were developed to determine hydrogen peroxide (H2O2) and persulfate (S2O82-) based on the etching of GNRs which was detected from either naked-eye or UV-visible spectroscopic method. The changed size of GNRs was directly related to the concentration of H2O2 and S2O82-. To obtain the optimum conditions for H2O2 and S2O82- determination, CTAB concentration, FeSO4 concentration and detection time were investigated. For H2O2, the working range was 0.20 to 3.0 mM where the good linear working range was in the range of 0.20 to 0.80 mM. LOD was 0.08 mM. Moreover, the GNRs conjugated hydrogel was tested for H2O2 determination. For S2O82-, the working range was 0.10 to 5.0 mM where the good linear working range was in the range of 0.10 to 1.0 mM. LOD was 0.022 mM. For the determination of S2O82- in real water sample, the effect of interfering anions was studied and found that the tolerance limits were 500 times over S2O82- concentration. This multicolor sensor could be used for S2O82- determination in pond-CU water sample with acceptable accuracy (%recovery = 104) and precision (%RSD < 2).
CONSTITUTIONAL CROSSROADS: INDIA’S PROPERTY RIGHTS SAGA IN CONSTITUTIONAL LORE
Authors: Lal Stuti , Kamboj Jayestha , Sharma Sarthak
Published: June 2024

The Right to own Property has been a contentious topic in India ever since the constitution was drafted. Originally protected by Article 31 as a Fundamental Right, it was progressively diluted by a series of changes designed to limit judicial interference and preserve the legislative branch's authority. Property rights were declared mere Constitutional Rights under Article 300A of the Constitution when the 44th amendment removed them from part III of the Constitution. Through land reforms, the founding fathers sought to strike a compromise between upholding pre-existing property rights and establishing an equitable society. Nevertheless, the battle between the courts and the legislature resulted in a number of corrective rulings and constitutional revisions between 1950 and 1980. The paper examines later modifications and significant cases pertaining to property rights, including certain cases and Amendments and further contrasts India's property rights with those of the United Kingdom and the United States, where they are based under Fundamental Law. This paper contends that the 44th Amendment violated the Socialist principles outlined in the preamble, making it in essence unlawful and has tried to showcase through various case laws, the arbitrariness that the government has portrayed while passing such Constitutional Amendments.
La infancia a la sombra de las catedrales: prosopografía y 'cursus honorum' de los clerizones de la catedral de Toledo (1450-1530)
Authors: De la Flor Gutiérrez Juan Carlos
Published: June 2024

Son escasos en el momento actual los estudios que descienden verdaderamente al nivel prosopográfico para observar exhaustivamente la realidad de los niños del coro de las catedrales hispanas bajomedievales. Ese es precisamente el objetivo de este artículo, complementar los estudios institucionales ya existentes para la catedral de Toledo con el enfoque prosopográfico. Gracias a los libros de Presencias en Tercios, a las Actas Capitulares y a los libros de Sucesión de Prebendas −todos en el Archivo Capitular de Toledo−, se puede comprender en gran medida la identidad de la infancia a la sombra de la catedral de Toledo. Tras recoger en una base de datos relacional y analizar la información cuantitativa y cualitativa seleccionada, se propone a los lectores un recorrido por la vida de estos «clerizones». Comenzará con una contextualización institucional, para después exponer sus orígenes geográficos y sociales, los emolumentos que recibían y su posterior carrera eclesiástica.