bluuebunny/crossref_metadata_2025 huggingface dataset:
Eco Art Bamboo and Silat Spirituality in the Integrated Space Design
Authors: Poerwoko Dr. Widya
Published: July 2020

ABSTRACTToday environmental damage has become an alarming issue. Such a problem also occurs at Sleman located in the foot of Mount Merapi, Yogyakarta. Illegal sand mining around settlements has resulted in shrinking plant populations and damage to land use, which has resulted in decreased groundwater and surface water. Environmental damage begins with fragmentation in people’s worldview resulting from the emerging humanism-ecology, knowledge-values, and the body-spirituality separations. Pencak silat, as an indigenous Indonesian martial art that is subject to the harmony between humans and the natural environment in which they live, can inspire the awareness of local people to reconsider the habits harmful to the environment and nature. The Integrated Space Design as an aesthetic manifestation of Eco-Art is an artwork created to address environmental problems occurring in the foothills of Mount Merapi by creating a space that bridges the interactions between humans, between humans and their artificial environment, and between humans and the surrounding natural environment by using bamboo plants as the main media, and silat spirituality as the primary inspiration the local community’s capacity of living, both ecologically and spiritually. ABSTRAK Perubahan iklim dalam fenomena Global Warming penting diperhatikan. Meski peristiwa tersebut sulit dibayangkan oleh masyarakat pedesaan, namun faktanya fenomena tersebut telah mengakibatkan para petani mengalami kegagalan panen dan hampir tidak dapat lagi memprediksi waktu tanam. Di luar fenomena tersebut, persoalan lingkungan juga terjadi di kaki Gunung Merapi, Sleman, Yogyakarta. Penambangan pasir di pemukiman, telah mengakibatkan menyusutnya populasi tumbuhan dan rusaknya tata guna lahan, sehingga berdampak pada menurunnya permukaan air tanah dan air permukaan. Kerusakan lingkungan berawal dari terpecahnya cara pandang orang akibat dari munculnya pembedaan antara humanisme dengan ekologis, pengetahuan dengan nilai-nilai, dan tubuh dengan spiritualitas. Pencak silat, sebagai seni bela diri Indonesia yang tunduk pada keselarasan antara manusia dengan lingkungan alam tempat hidupnya, dapat menggugah kesadaran orang setempat untuk mempertimbangkan kembali kebiasaannya yang dapat merugikan lingkungan dan alam. Integrated Space Design sebagai manifestasi estetis Eco Art, merupakan karya seni yang diciptakan untuk menjawab persoalan lingkungan yang terjadi di kawasan kaki Gunung Merapi, yaitu dengan mewujudkan ruang, wadah atau jembatan interaksi antar manusia, manusia dengan lingkungan buatannya dan alam seputar hidupnya, dengan menggunakan tanaman bambu sebagai medium utamanya, dan spiritualitas silat sebagai inspirasinya sehingga dapat melestarikan daya hidup masyarakat setempat, baik secara ekologis maupun spiritual.
ANALISIS KEPUASAN WISATAWAN DOMESTIK PADA ATRAKSI DOLPHIN DI PANTAI LOVINA, BULELENG
Authors: Ayu Antari Kadek , Suardana I Wayan , Dewi LGLK.
Published: July 2020

Lovina beach is known for the dolphin attraction. Watching dolphin attraction, tourists were transported by boat. As a provider, the helmsman tried to give the best of service to the tourists. However, there were various views of both positive and negative opinions from tourists regarding the services rendered during used. Thus, it must be known to be the dosmetic tourist satisfaction using boat service at Lovina Beach. Data collected by the method of observation, interviews, questionnaires, documentation and literature study. Determination of the sample using purposive sampling technique. Data analysis techniques using customer satisfaction index and importance performance analysis in the form of a Cartesius diagram. The results show that the level of tourist expectation is 4.28 which means it is in the very important category. Furthermore, the value of the captain's performance level obtained a value of 3.77 which was categorized as good. Calculation of the gap value shows the gap between the level of expectation and the level of performance with the acquisition of a value of -0.51. Analysis of the level of tourist satisfaction based on the calculation of the customer satisfaction index shows that tourists are satisfied with a value of 75.54%. There are 4 indicators that need to be prioritized to be improved, including the availability of life jackets, responsibility for the safety of tourists, a sense of security while using a boat and the helmsman has the ability to create good relationships with tourists.
Model data warehouse untuk Operasional petugas pemadam kebakaran Pada dinas pemadam kebakaran provinsi DKI Jakarta
Authors: Munawar Kharis , Spits Warnars Harco Leslie Hendric
Published: July 2020

In this paper we design 2 data warehouse design models for the DKI Jakarta fire department. The first data warehouse design model is categorized as a fact constellation schema, where there are 3 fact tables, 2 dimensional tables and 1 sub dimension table, while the second data warehouse design model is a fact constellation schema which consists of only 3 fact tables as well. Both of these data warehouse models are displayed with the intention that the implementation of the data warehouse based on the fire extinguisher data will look different and that will certainly be faster by using the 2nd model which is categorized as an non normal data warehouse model which only consists of 3 fact tables which the lack of a join process in the fact table and the dimensions of the data warehouse will speed up the query process in building the data warehouse report. The design model of the data warehouse is designed based on 4 excel table files, each of which has 1 table downloaded from the DKI Jakarta fire department's website on the website data.jakarta.go.id.
Pengaruh Media Video Tentang Pariwisata di Kabupaten Pesawaran Terhadap Peningkatan Pengetahuan Mahasiswa
Authors: Zainal Anna Gustina
Published: July 2020

This study uses realistic visualization in the form of photos which are the result of photographic elements, as well as visualization with infographic forms which are illustrative elements in visual communication design. the research uses True Experimental method with 2x2 factorial design and uses Pretest, Posttest, and Control Group Design. The purpose of this study is to examine the effect of visual presentation and language style through video media for increasing student knowledge and analyzing the most effective combination of messages on video media about tourism in Pesawaran District. From this research it is found that visual presentation and language style through video may influence improvement of student knowledge about tourism in Pesawaran Regency. All combinations of visual presentation and language style will influence knowledge improvement.Keywords: Video Media, Tourism, Pesawaran Regency
Rekomendasi Kebijakan Pemulihan Pariwisata Pasca Wabah Corona Virus Disease 2019 (Covid-19) di Kota Bandung
Authors: Herdiana Dian
Published: July 2020

COVID-19 is a pandemic disease that has infected many cities in Indonesia, the impact caused by the spread of COVID-19 involves many aspects including economic, social, cultural, tourism and many more. Based on the problems mentioned above, this article is intended to describe the impact of COVID-19 on tourism in the city of Bandung which is one of the tourism city in the province of West Java, this article is also intended to recommend what policy should be made by the government of the Bandung City to restore tourism to the condition before the COVID-19 outbreak. This study uses a model building method with a descriptive analysis approach. The results revealed that tourism is one of the sectors most affected by the COVID-19 outbreak in the city of Bandung, efforts to restore tourism from COVID-19 must be comprehensive and sustainable. Bandung City Government and tourism entrepreneurs are demanded to carry out communication and coordination to develop tourism recovery policy instruments which include internal recovery efforts such as disaster management, organizational capacity building and external recovery efforts such as tourism relaxation policy and tourism promotion.

Keywords: Village Tourism, Community, Empowerment, Development
Wisata Kelautan Berkelanjutan di Labuanbajo, Nusa Tenggara Timur: Sebuah Study Tentang Persepsi Masyarakat Kawasan Pesisir
Authors: Khan Alexander M. A. , Musthofa Imam , Aminuddin Indarwati , Handayani Fitri , Kuswara Ratna N. , Wulandari Ajeng
Published: July 2020

Community-based tourism is one type of tourism that involves community participation to achieve the goal of sustainable tourism development. The purpose of this study is to determine the tourism potential to be managed by the community based on people's perceptions of the existing tourism potential, as well as identifying people's perceptions of national, regional, and also traditional policies in tourism. This research was divided into several data collection, internal-external factor analysis, data analysis and development strategy analysis using the SWOT matrix. The conclusions of this study are (1) Natural resources in Labuan Bajo which can be used as tourist attractions that have not been managed and developed properly. Those are Ara Mountain, Ina Mountain, Namong Island, Kelaki Island, Kima Island, Komodo, wild horses and buffalo, savannah, Rangka Cave, Gosong, Pasir Timbul, Mangrove and several underwater object such as Manta and coral reefs. (2) Based on a quantitative strategy, the development strategy that is suitable to be carried out in Labuan Bajo is the S-O Strategy which is carried out by utilizing the strength needed to achieve the opportunities that exist. (3) Based on a qualitative strategy, a suitable strategy to be carried out in Labuan Bajo is related to the improvement of public facilities, partnerships with universities, improvement of the people's economy, and the improvement of regional and group economies.

Keywords: Community based tourism, local communities, natural resources, potencies, SWOT analysis
Strategi Penanganan Krisis Dampak Erupsi Gunung Agung oleh Pelaku Pariwisata Ubud
Authors: Dewi Gusti Ayu Marcela , Sunarta I Nyoman , Arida I Nyoman Sukma
Published: July 2020

The phenomenon of Mount Agung eruption has a negative impact on Ubud tourism. The impact of this event was greater than the 2002 Bali bombing. Generally, governments and tourism actors in Ubud have no yet a specific management to reduce the negative impact of Mount Agung eruptions. This research is qualitative descriptive method approach with case study research. Primary data in this study were obtained from interviews with informants namely; government, tourism institutions (NGOs) and tourism industry players in Ubud. Researchers also used online desk research to collect the secondary data that already exists on the internet from trusted sources in the form of public documents (images, e-news), or personal documents (e-mail, work reports and results of minute meetings). The result of this study, there were obtained four stages of crisis handling carried out by Ubud’s tourism actors namely 4R such as, reduction, readiness, response, and recovery. To minimize the negative impact of Mount Agung eruption, stakeholder needs synergetic all elements such government, non-government organizations (NGOs), industry actors, communities and other stakeholders to keep tourism sector remains conducive.

Keywords: strategy of tourism actors, Mount Agung eruption, crisis
Menikmati Kopi, Memaknai “Joss” Studi Eksploratif terhadap Pengalaman Wisatawan Domestik didalam Mengonsumsi Kopi Joss
Authors: Hartono Yudo , Wijanarti Sri Widya
Published: July 2020

This study aims to explore the meaning from the experience of Kopi Joss consumption from domestic tourist’s perspective. Kopi Joss is a name of coffee little shop that called angkringan near Malioboro Street in Yogyakarta. In this study, Holt’s Typology is used to analyze the meaning of the consumption from cultural and social perspective and this research uses qualitative perspective with domain analysis to describe the depth of the data. The result shows Kopi Joss meaning is related to the context where the consumption took place and the result can be used to strengthen the position of Kopi Joss in the future.

Keywords: Kopi Joss, Domain analysis, coffee meaning
Caracterização e qualidade de vida de cuidadores familiares: proposta de tecnologia educacional
Authors: Santos do Monte Letícia , Castro de Andrade Grayce Daynara , Barbosa Magalhães João Lucas , Picanço da Silva Thamilly Joaquina , Celis de Cárdenas Anneli Mercedes , Pinheiro da Silva Marlucilena , Uchôa Maira Beatrine da Rocha , Oliveira do Nascimento Rosana , Rodrigues Barbosa Nemer Camila , Hage-Melim Lorane Izabel da Silva
Published: July 2020

Objetivo: Propor um instrumento tecnológico para auxiliar os hábitos de vida e saúde dos cuidadores familiares. Métodos: Estudo descritivo, exploratório, de abordagem quantitativa. Sendo os participantes do estudo cuidadores familiares de pacientes com Parkinson e/ou Alzheimer do projeto REVIVER da Universidade Federal do Amapá. Utilizaram-se dois instrumentos para coleta de dados: o Questionário Adaptado do IBGE e o WHOQOL-BREF. Os dados coletados foram tabulados em Excel e analisados por meio do software SPSS. A proposta tecnológica envolveu apresentação de um protótipo composto por vídeos desenvolvidos em quatro etapas: 1) Aplicação de questionários; 2) Planejamento e Roteiro do instrumento audiovisual; 3) Definição de espaço de produção; 4) Edição final. Resultados: Participaram do estudo 25 cuidadores familiares – a maioria mulheres (80%); maiores de 50 anos (80%); com renda familiar de até 3 salários mínimos (60%). Os domínios da vida considerados foram: realização das atividades físicas do cotidiano; desempenho para trabalho, sono e repouso, os cuidadores apresentaram frequência de pensamentos negativos. Com base no perfil coletado neste estudo, optou-se por proposta metodológica audiovisual. Conclusão: O instrumento proposto visa facilitar o acesso à informação, utilizando conteúdo didático, além de fornecer proposituras para minimizar as adversidades enfrentadas pelos cuidadores.
The accidental loss of guidewire during emergency femoral central venous cannulation: A case report
Authors: Goyal Sham Sunder , Panditrao Mridul Madhav , Garg Asha
Published: July 2020

Many complications are reported with placement of the central venous catheter. They can be varied and graded as minor/insignificant, self-limiting, and not requiring any intervention to major/serious and requiring urgent intervention to save the life of the patient. Most of them can be minimized with certain precautions, use of aids and improved skill and experience of the operator. We are presenting a case report with such a complication, which is much rarer, happened, even in the hands of a very senior and experienced operator, requiring urgent intervention.
LUPUS: Trends of the disease in Northwest Punjab
Authors: Singh Bhandari Gurbir
Published: July 2020

Objectives:

The aim of this study was to study the clinical profile of systemic lupus erythematosus (SLE) patients from a tertiary care center in Northwest Punjab.

Materials and Methods:

It was an observational cross-sectional study conducted at the Rheumatology Clinic, Adesh Hospital, Bathinda. Twenty-five patients classified to be suffering from SLE as per standard classification criteria (Systemic Lupus International Collaborating Clinics [SLICC]) were enrolled after obtaining consent for the same. Socio-demographic data, disease duration, disease activity, and treatment received were recorded. Analysis was performed for the various parameters.

Results:

The majority of patients (88%) were females with a female to male ratio of 7.3:1 with mean age of 30.5 years. Mucocutaneous involvement (92%) followed by musculoskeletal (84%). Nephritis was seen in 36%, deforming arthritis in 8%, and pleural involvement in 36% while ILD in 12%. Pericarditis was seen in 16%, and myocarditis was seen in 12%. Neurological involvement was seen in 36% patients with two cases of thrombotic CVA, one case of SAH and three cases of seizure disorder. Psychiatric symptoms were observed in 16% cases. AIHA was seen in 12%, leukopenia in 44%, and thrombocytopenia in 68%. Most common antibody was anti-dsDNA being present in 48% cases, followed by Anti Ro-60, Ro-52, Anti Sm, and Anti U1RNP antibody.

Conclusion:

We found a striking difference in the prevalence of pleuropulmonary features, neuropsychiatric features, Leukopenia, and thrombocytopenia in our subgroup of population as compared to the earlier studies from central and southern parts of India thus further emphasizing the fact that ethnic backgrounds predispose a patient for different phenotype.
Klasifikasi Komentar Bullying pada Instagram Menggunakan Metode K-Nearest Neighbor
Authors: Candra Reski Mai , Nanda Rozana Anindya
Published: July 2020

Bullying merupakan tindakan negatif yang dilakukan oleh orang lain secara terus menerus atau berulang. Tindakan ini kerap kali menyebabkan korban tidak berdaya, terluka secara fisik maupun mental. Tindakan bullying kini telah memasuki dunia sosial media. Instagram menjadi salah satu media sosial yang menjadi tempat terjadinya bullying melalui komentar pada foto/video yang diunggah oleh artis/selebgram. Salah satu cara mewaspadai tindakan bullying adalah dengan cara mengklasifikasi komentar yang bersangkutan di media sosial (dalam hal ini Instagram) menggunakan metode klasifikasi K-Nearest Neighbor (KNN). Jumlah data yang digunakan sebanyak 1000 data, dimana 500 merupakan bullying dan 500 tidak bully. Dengan adanya penelitian ini diharapkan dapat membantu seseorang untuk mengetahui perbedaan komentar bullying dan yang bukan bullying. Metode KNN telah diuji menggunakan 5 nilai k yang berbeda (7, 9, 11, 13, 15) dengan pembagian data 70:30, 80:20 dan 90:10 menggunakan confusion matrix, dengan masing-masing fold yang dibentuk 4, 5 dan 10 sehingga menghasilkan total 95 fold pengujian, pengujian ini menghasilkan akurasi rata-rata sebesar 58,83%. Akurasi tertinggi terdapat pada k 13 dengan perbandingan 90:10 data pada fold ke 6 yaitu sebesar 77%.
Modified PC/ASA/PMMA Blends: Improved Compatibility, Mechanical Properties and Synergistic Effects with Natural Rubber
Authors: Tang Ruogu , Dong Wenfa , Chen Dingfang
Published: July 2020

In this work, ABS-g-MAH was used as the compatibilizer in poly carbonate/acrylonitrile styrene acrylate/poly(methyl methacrylate) blends. The polymer blends were prepared via a two-step method: first, raw PC, ASA, PMMA resins and ABS-g-MAH additives were completely mixed and granulated by extrusion molding, and then the standard PC/ASA/PMMA blends samples were obtained by injection molding. A comprehensive characterizations were performed on the PC/ASA/PMMA blends of their morphologies, mechanical properties and thermal properties. The results showed that the addition of ABS-g-MAH could promote the compatibilities among PC, ASA and PMMA, and ABS-g-MAH would significantly alter the mechanical and thermal properties of blends. In addition, the modified PC/ASA/PMMA was well compatible with natural rubber and cause less cytotoxicity when interacting with cells.
KinFragLib: Exploring the Kinase Inhibitor Space Using Subpocket-Focused Fragmentation and Recombination
Authors: Sydow Dominique , Schmiel Paula , Mortier Jérémie , Volkamer Andrea
Published: July 2020

Protein kinases play a crucial role in many cell signaling processes, making them one of the most important families of drug targets. In this context, fragment-based drug design strategies have been successfully applied to develop novel kinase inhibitors, usually following a knowledge-driven approach to optimize a focused set of fragments to a potent kinase inhibitor.

Alternatively, KinFragLib is a new method that allows to explore and extend the chemical space of kinase inhibitors using data-driven fragmentation and recombination, built on available structural kinome data from the KLIFS database for over 2,500 kinase DFG-in complexes. The computational fragmentation method splits the co-crystallized non-covalent kinase inhibitors into fragments with respect to their 3D proximity to six predefined functionally relevant subpocket centers. The resulting fragment library consists of six subpocket pools with over 7,000 fragments, available at https://github.com/volkamerlab/KinFragLib.

KinFragLib offers two main applications: (i) In-depth analyses of the chemical space of known kinase inhibitors, subpocket characteristics and connections, as well as (ii) subpocket-informed recombination of fragments to generate potential novel inhibitors. The latter showed that recombining only a subset of 624 representative fragments generated a combinatorial library of 6.7 million molecules, containing, besides some known kinase inhibitors, more than 99% novel chemical matter compared to ChEMBL and 63% molecules compliant with Lipinski's rule of five.
D4h Local Symmetric dysprosium(III) Single-Molecule Magnet with Energy Barrier Exceeding 2000 K
Authors: Ding Xia-Li , Zhai Yuan-Qi , Han Tian , Chen Wei-Peng , Ding You-Song , Zheng Yan-Zhen
Published: July 2020

Three six-coordinate Dy(III) single-molecule magnets (SMMs) [Dy(OtBu)2(L)4]+ with D4h local symmetry are obtained by optimising the equatorial ligands. Compound 1 where L = 4-phenylpyridine shows an energy barrier (Ueff) of 2075(11) K, which is the third largest Ueff, and the first Ueff > 2000 K for SMMs with axial-type symmetry so far.
Ultra-Fine Ni2P Nanoparticles Decorated R-GO: Novel Phosphidation Approach and Dibenzothiophene Hydrodesulfurization
Authors: Tzitzios Vasileios , Pillai Vishnu , Gioti Christina , Katsiotis Marios , Karagiannis Thomas , Gournis Dimitrios , Karakassides Michael A , Alhassan Saeed
Published: July 2020

Nanostructured transition metal phosphides gathered last years an elevated scientific interest, due to their unique physical-chemical properties. Nickel phosphide nanoparticles, with the controllable crystal structure, from the metal rich tetragonal Ni12P5 to the phosphorous rich hexagonal Ni2P, and hcp Ni2P decorated r-GO (reduced graphene oxide), nano-hybrid materials have been synthesized via a novel one step organometallic approach in primary-tertiary aliphatic amines mixture. The nanoparticles are monodispersed, with spherical shape and controllable size in the sub-10 nm regime and decorate uniformly the surface of the r-GO, leading to the formation of Ni2P/r-GO hybrid materials. The materials were characterized by powder XRD, TEM and Raman spectroscopy and catalytically evaluated for the dibenzothiophene hydrodesulphurization (HDS) reaction. The results show that the role of the tertiary amine is crucial for the phosphidation process and the r-GO is an ideal alternative, to the traditional inorganic ones, support for the immobilization of the catalytically active component, preventing significantly sintering effects.
Role of Computed Tomography in Evaluation of Renal Masses
Authors: Shrishail Adke  , Dinesh Potdar
Published: July 2020

At present there are various ways to recognize and evaluate kidney mass. A systematic methodological approach is needed to ensure a complete assessment of the suspected kidney mass, because each x-ray modality has relative strengths and weaknesses for an accurate diagnosis. Despite the lack of sensitivity and specificity, intravenous pyelography (IVP) remains the original diagnostic method in many cases because it plays a role in the assessment of hematuria. Intravenous pyelography with or without nephrotomography can detect a lot of kidney mass and provide information about kidney function. As the modality of imaging has expanded extensively, the measurement of adverse renal mass has improved significantly. The heterogeneous development, necrosis or calcification of such a by-of renal cell carcinoma is strongly suggestive. This research describes early-stage accidental renal cell carcinoma as correlated with symptoms of patients with renal cell carcinoma. It has significant implications on therapeutic strategies such as partial nephrectomy, etc. and increases the recovery of premature lesions. It suggests that the renal mass requires monitoring at age over 40 and high-risk classes such as the background of renal cell carcinoma, VHL, etc. The most common and successful modality for the measurement and characterisation of renal weight remains computational multidetector tomography (MDCT). The diagnostic efficiency of RCC in characterising and predicting the severity of disease is vastly enhanced by MDCT scans with an increase in spatial resolution and the potential to provide multiplanar and 3D recreations.
Protective Effects of Edible Plants against Nicotine Induced Reproductive Toxicity –A Review
Authors: Kanimozhi S  , Bupesh G  , Sumathy G  , Jeganath S
Published: July 2020

Numerous examinations have announced that the Nicotine present in tobacco smoke adverse affects sperm parameters, fundamental plasma, and different other richness factors. These harms are because of the natural finding that smoking expands the degree of free radicals, consequently bringing about oxidative pressure. Accordingly, an increment of free radicals, DNA harm and lipid peroxidation in human sperm may happen to bring about impedance of sperm quality. nicotine organization in trial creatures was initiate to influence spermatogenesis, epididymal sperm count, motility and treating capability of sperms. Huge quantities of restorative herbs have been recorded in siddha framework that improve spermatogenesis and increment the nature of sperm. The present review gives an outline on the relationship between male richness incited by nicotine and defensive impacts of different natural plants on it. The paper additionally features the dynamic, common standards, and rough concentrates of plants, which have been valuable in improving nicotine instigated testicular harms and supportive in spermatogenesis and multiplication. Despite the fact that the discoveries of this survey propose numerous herbs are extremely viable against nicotine actuated male barrenness still increasingly clinical preliminaries are prescribed to show their viability on nicotine instigated male infertility
Enhancing the content uniformity of low dose drugs by using different granulation techniques
Authors: Ajmal K T  , Arun Radhakrishnan
Published: July 2020

Progress in pharmaceutical research has delivered very strong medications, which require cautious definition and creation so as to deliver strong oral measurement structures with satisfactory homogeneity and physical stability. Mixing and formulation of low dose medications can be individually testing because of issues identified with isolation, content uniformity and physical stability. A cautious control on these variables is vital while fabricating low dose drugs. Choice of excipients for the particular strides during detailing/process improvement is basic to build up a homogenous and isolation free low portion definition. Numerous sorts of categories of gear have been intended towards encourage blending of low portion drugs with excipients. A side from traditional detailing strategies (like wet granulation, dry granulation, and direct compression) different new procedures have been announced, for example, high shear granulation, requested blending and spry drying. These innovative headways ensure enhanced the assembling and nature of low dose drugs items by accomplishing their predefined goal of substance consistency through outblending and plan of low dose drugs. Blending and detailing of low portion drugs are advanced work and includes part of issues related to isolation, content consistency and physical soundness which can be constrained by right choice of material, strategy and machine. This article surveys current headways identified with plan systems of low dose drugs.
Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1highmemory phenotype CD4 T cells
Authors: Symonds Alistair LJ , Zheng Wei , Miao Tizong , Wang Haiyu , Wang TieShang , Kiome Ruth , Hou Xiujuan , Li Suling , Wang Ping
Published: July 2020

The transcription factors Egr2 and 3 are essential for controlling inflammatory autoimmune responses of memory phenotype (MP) CD4 T cells. However, the mechanism is still unclear. We have now found that the Egr2+subset (PD-1highMP) of MP CD4 T cells expresses high levels of checkpoint molecules (PD-1 and Lag3) and also markers of effector T cells (CXCR3 and ICAM-1). Egr2/3 are not required for PD-1highMP CD4 cell development but mediate a unique transcriptional programme that effectively controls their inflammatory responses, while promoting homeostatic proliferation and adaptive responses. Egr2 negative PD-1highMP CD4 T cells are impaired in homeostatic proliferation and adaptive responses against viral infection but display inflammatory responses to innate stimulation such as IL-12. PD-1highMP CD4 T cells have recently been implicated in rheumatoid arthritis pathogenesis, and we have now found that Egr2 expression is reduced in PD-1highMP CD4 T cells from patients with active rheumatoid arthritis compared with healthy controls. These findings demonstrate that Egr2/3 control the inflammatory responses of PD-1highMP CD4 T cells and maintain their adaptive immune fitness.
O jornalismo empresarial no Brasil e o papel institucional da imprensa enquanto “voz da sociedade”: os jornais O Globo e O Estado de São Paulo na reabertura democrática após o golpe civil militar de 1964
Authors: Da Luz Thaíze Ferreira
Published: July 2020

Este artigo tem por objetivo fazer uma análise, ainda que introdutória, sobre o papel institucional da imprensa brasileira durante o período de transição democrática e implantação da Nova República identificando a mudança de postura desses periódicos em momentos distintos da História do Brasil, ou seja, analisar o discurso empregado por essas folhas na defesa do golpe civil militar de 1964 e posteriormente, um discurso de defesa de liberdades e garantias individuais na transição democrática. Nossa análise documental foi feita a partir do discurso presente nos jornais O Globo e O Estado de S. Paulo e bibliografia de apoio, tendo como marco temporal a implantação regime autoritário em março e abril de 1964 e, posteriormente os anos de 1988 e 1989, já na transição democrática. Preliminarmente nossos resultados indicam que em ambos os casos a justificativa dos jornais analisados foi a mesma: a defesa de interesses públicos. Palavras-chave: Papel institucional da imprensa brasileira. Redemocratização. O Globo. O Estado de S. Paulo. Eleições de 1989
Desafios e dificuldades no cotidiano da crítica jornalística: a experiência de ombudsman no Jornal da Manhã (PR)
Authors: Gadini Sergio Luiz
Published: July 2020

Dia 2 de Setembro de 2007, o Jornal da Manhã (JM), de Ponta Grossa, Paraná, apresentava ao leitor uma versão atualizada do projeto gráfico e editorial do periódico mais antigo em circulação contínua na Cidade. Na remodelação, o JM lança um espaço inédito para crítica de mídia na história do jornalismo diário paranaense: a coluna Ombudsman. Era a primeira vez que um diário local/regional criava espaço para análise da produção jornalística no Estado. O presente texto descreve a experiência da criação e manutenção da coluna de ombudsman no JM, até a extinção do espaço de crítica institucional pelo próprio diário. O relato e a descrição do exercício da crítica dialogam com os desafios da implantação da proposta e as dificuldades no fazer cotidiano da análise jornalística. De 02/09/2007 até 30/03/2011, tempo em que a coluna circulou semanalmente no Jornal, na edição de domingo, o espaço contou com a participação de quatro jornalistas que fizeram a crítica diária, em um mandato de 12 meses cada. De forma analítica, o artigo recupera a experiência, no período em que o JM manteve o espaço de crítica (com blog para atualização diária e uma página standard na edição dominical), destacando as características, limites e desafios da análise jornalística, com ênfase no período do primeiro mandato de ombudsman no JM, que compreende os 12 meses iniciais da experiência de crítica (02/09/2007 a 31/08/2008).
ABORTO CONSENTIDO: DIREITO FUNDAMENTAL DA MULHER QUE DEVE SER TUTELADO PELO TRIBUNAL CONSTITUCIONAL ENQUANTO GARANTE DA DEMOCRACIA
Authors: Forni João Paulo , Kurkowski Rafael Schwez
Published: July 2020

O presente artigo defende a legitimidade do STF para descriminalizar o aborto consentido até o primeiro trimestre da gestação. Mediante análise documental e revisão bibliográfica, demonstra-se que a democracia, para além do critério majoritário, exige o respeito aos direitos fundamentais, não obstante contra maiorias. A tutela desses direitos incumbe ao Tribunal Constitucional, o qual, ao empregar razões públicas de forma racional, representa argumentativamente a sociedade. Porque o aborto consentido caracteriza um direito fundamental da mulher, decorrente da sua dignidade, o Tribunal Constitucional deve tutelá-lo, o que resulta na inconstitucionalidade da legislação penal que incrimina o aborto, desde que realizado no primeiro trimestre da gestação.
JUDICIALIZAÇÃO DO DIREITO À SAÚDE: REFLEXÃO ACERCA DO FORNECIMENTO DE MEDICAMENTOS NÃO INCLUÍDOS EM ATOS NORMATIVOS DO SUS
Authors: Martins Urá Lobato
Published: July 2020

RESUMO: O artigo realiza uma análise crítica sobre a judicialização do direito à saúde, com enfoque para o caso do fornecimento de medicamentos não incluídos em atos normativos do Sistema Único de Saúde (SUS). Dessa forma, o artigo visa dar resposta às seguintes questões norteadoras: o Poder Público deve ser obrigado a fornecer medicamentos não incluídos na lista do SUS? Qual o posicionamento atual dos Tribunais Superiores a respeito do tema? Quais critérios foram definidos pelo Superior Tribunal de Justiça durante o julgamento do Recurso Especial n.º 1.657.156-RJ? Para tanto, será feita revisão da literatura com a finalidade de demonstrar as correntes doutrinárias sobre as questões controversas sobre o tema, seguindo abordagem qualitativa, com pesquisa bibliográfica, documental e jurisprudencial sobre o direito à saúde. Ao final, serão apresentadas reflexões acerca dos critérios e parâmetros utilizados para legitimar a decisão judicial que obrigue o Estado a fornecer medicamentos não incluídos na lista do SUS.
DE NOVO, O SISTEMA REGISTAL AUSTRÍACO
Authors: Jardim Mónica
Published: July 2020

Através deste estudo pretende-se dar uma perspectiva geral do sistema registral austríaco. Visando tal objetivo, começamos por fazer uma sucinta resenha histórica e breve apresentação da função desempenhada pela publicidade registral, do sistema tabular ou do livro fundiário austríaco, na alteração da situação jurídico-real. De seguida, apresentamos as características do sistema tabular ou do livro fundiário. Posteriormente, analisamos o sistema tabular ou do livro fundiário, nos aspectos que de seguida se enumeram: i) Os livros de registro; ii) Assentos registrais; iii) O processo de registro; iv). O Recurso do decreto tabular; v). A ação de cancelamento da entabulação/extabulação e a sua anotação; vi). A prescrição extratabular ou contratabular (auberbücherliche Ersitzung). Por fim, examinamos, brevemente, uma figura característica do direito austríaco: a Anmerkung der Rangordnung der beabsichtigten Veräuberung – a anotação da ordem de precedência ou a anotação da ordem de prioridade.
The Right to Vote: Implications of New Zealand's International Legal Obligations and the New Zealand Bill of Rights Act 1990
Authors: McClelland Sarah
Published: July 2020

This article challenges several aspects of the then-new electoral laws outlining the MMP ("Mixed Member Proportional") system, and claims that they are not consistent with international obligations or with the right to vote set out in the New Zealand Bill of Rights Act 1990. The aspects covered are the rules relating to voting by prisoners, the residential requirements for voting, and the election of list MPs.
10-year Trajectories of Alcohol Consumption in Older Adult New Zealanders
Authors: Szabó Ágnes , Towers Andy , Sheridan Janie , Newcombe David
Published: July 2020

Objectives
Older adults are often treated as a homogeneous drinking group, but research suggests that they engage with alcohol in various ways, ranging from abstention to heavy drinking. The study aimed to (i) identify subgroups of older adults based on changes in frequency and quantity of alcohol use over 10 years and (ii) examine co-occurring changes in mental and physical health.

Method
Data were collected biennially between 2006 and 2016 from 2,632 New Zealanders (55–70 years old at baseline). Latent class growth analysis was performed to identify trajectories of alcohol use. Co-occurring changes in physical and mental health were examined using latent growth curve analysis.

Results
Five drinking profiles emerged: (i) infrequent, low-quantity consumers; (ii) highly frequent, low-quantity consumers; (iii) moderately frequent, high-quantity consumers; (iv) moderately frequent, low-quantity consumers; and (v) highly frequent, high-quantity consumers. Drinking trajectories demonstrated no change or slight declines in frequency and quantity over time. Frequent and moderately frequent, high-quantity drinking was more prevalent among men, younger participants, and active smokers. Moderately frequent, heavy drinkers were in very poor health. Frequent and moderately frequent, low-quantity drinking was associated with better health and economic well-being. Infrequent, low-quantity consumers were more likely to be women and in poor health.

Discussion
The five drinking profiles indicate that older adults engage with alcohol in diverse ways. Two of these patterns indicated potentially hazardous use, which highlights the need for screening and intervention in this age group.
Monomyth or Monogamyth? Polyamory’s Conceptual Challenges to the Hero’s Journey
Authors: Beggan James K.
Published: July 2020

In the context of polyamorous relationships, a unicorn can be defined as a single, bisexual woman interested in forming a relationship with a heterosexual couple. Heroism scholars have suggested that the hero’s journey (or monomyth) can be used as a framework for understanding everyone’s life. By extension, it would be possible to frame the search for a receptive unicorn as a hero’s quest. Unicorn hunters are stigmatized by the general public for challenging the monogamyth, i.e., the monogamy norm. They are also criticized by the polyamorous community for privileging their own interests ahead of those of the women they are seeking. By finding a unicorn, a couple may disrupt the stability of their own relationship in addition to harming the unicorn’s well-being. The quest for a unicorn raises a warning about encouraging people to “follow their bliss” because of the possibility of producing collateral damage to the parties involved. In some instances, refraining from undertaking a heroic quest may be the better option.
History of Chhattisgarhi literature: an introduction
Authors: Sahu Yogesh
Published: July 2020

Chhattisgarh has its own historical background, in which Chhattisgarhi literature has been confined for a hundred years. The development of Chhattisgarhi folk literature has been created by the beliefs, culture and civilizations of Chhattisgarhi folk. Literary works composed in Chhattisgarhi language had started about a thousand years ago, but there was not enough literature created at that time, yet Chhattisgarhi Literary Tours literary works composed in different times are available. "This one thousand years literary journey is divided into three classes based on different eras. 1: -1. Saga era: from 1000 to 1500 AD2. Bhakti era: from 1500 to 1900 AD3. Modern era: 1900 to date

 

छत्तीसगढ़ की अपनी ऐतिहासिक पृष्ठभूमि है, जिसमें छत्तीसगढ़ी साहित्य को सौ वर्षों तक सीमित कर दिया गया है। छत्तीसगढ़ी लोक-साहित्य का विकास छत्तीसगढ़ी लोक की मान्यताओं, संस्कृति तथा उसकी सभ्यताओं से निर्मित हुआ है। छत्तीसगढ़ी भाषा में रचित साहित्यिक रचनाओं का आरंभ लगभग एक हजार वर्ष पूर्व हो चुका था, लेकिन उस समय पर्याप्त मात्रा में साहित्य-सृजन नहीं हुआ था फिर भी छत्तीसगढ़ी साहित्यिक-यात्रा विभिन्न कालों में रचित साहित्यिक रचनाएँ उपलब्ध हैं। ‘‘इस एक हजार वर्षों के साहित्यिक यात्रा को विभिन्न युगों के आधार पर तीन वर्गों में विभाजित किया गया है1:-1. गाथा युग: 1000 से 1500 ई. तक 2. भक्ति युग: 1500 से 1900 ई. तक3. आधुनिक युग: सन् 1900 से आज तक
The Effect of Using Music Classic (Mozart) towards Student Anxiety Before The Exams
Authors: Yuspitasari Risa , Rahmawati  , Dalimunthe Raudah Zaimah
Published: July 2020

This research aimed to discover the level of anxiety in students before the exam and the effect of music classic (Mozart) to reduce such anxiety. The study was conducted at SMP Negeri 1 Ciruas with students with a high level of anxiety, which has been revealed from the results of the anxiety scale questionnaire using a purposive sampling technique with a total of 68 respondents. This research was used with an experimental method consisting of an experimental group and a control group. From the treatment, the results showed pre-test 12.55 in the high category and post-test 7.852 in the medium category. This shows changes in the results before and after the treatment is given. It can be concluded that the effect of the use of music (Mozart) can reduce student anxiety before the test.
Mekanisme Penjualan Produk Tanpa Label Kadaluwarsa Perspektif Ekonomi Islam
Authors: Yarmunida Miti , Darmiati Eni
Published: July 2020

The purpose of this study is to describe the perspective of Islamic economics about the mechanism of selling products without an expiration date on the Home Industry Bread Hidayah in the Edge of the City of Bengkulu Hybrids. This study uses descriptive qualitative methods, data collection techniques by means of literature studies and interviews. Data analysis starts with a data reduction display and conclusion. This study concludes that the practice of selling products without an expiry date conducted by the owner of the home industry Roti Hidayah in the Edge of the City of Bengkulu Hybrids has not applied the principle of justice to consumers, namely by not including the expiration date of its business products.
NILAI-NILAI TASAWUF GENERASI MILENIAL
Authors: Nuraini Nuraini , Marhayati Nelly
Published: July 2020

Nilai-nilai Tasawuf Generasi Milenial. Tasawuf atau sufi sme merupakan hasil dari peradaban Islam yang keberadaannya sudah ada sejak dulu. Tasawuf seperti mengalami fase Revitalisasi di era generasi millennial ini. Perkembangan ilmu pengetahuan dan teknologi yang tak diimbangi dengan ajaran agama yang luhur membuat generasi millennial menjadi rakus dan jauh dari Tuhan. Kehadiran Tasawuf semakin bermakna, ketika tasawuf mampu menjadi oase di padang pasir yang tandus dan gersang bagi masyarakat modern yang mengalami krisis spiritual. Tasawuf dalam bentuk tarekat ataupun dalam bentuk yang sudah termodifi kasi akan menjadi solusi yang tepat ataupun obat bagi modernisasi dengan segala dampak dan konsekuensinya. Tasawuf dengan ajaran kerohaniannya dan akhlak mulianya semakin berperan penting dalam kehidupan masyarakat yang mulai terkikis dengan moral yang luhur. Tasawuf yang dulunya diklaim menjadi salah satu penyebab kemunduran Islam, dan ditanggapi dengan sikap yang negatif oleh beberapa tokoh Islam ketika itu, seperti Fazlur Rahman dan Al-Faruqi, kini semakin mendapat tempat di kalangan generasi millennial yang serba modern.
AKTUALISASI KURIKULUM KERANGKA KUALIFIKASI NASIONAL INDONESIA: Studi di Perguruan Tinggi Keagamaan Islam Swasta Bengkulu
Authors: Suradi A. Suradi , Amaliyah Aam
Published: July 2020

Aktualisasi Kurikulum Kerangka Kualifi kasi Nasional Indonesia:Studi di Perguruan Tinggi Keagamaan Islam Swasta Bengkulu. Penelitian ini untuk mengungkap tentang kesiapan perguruan tinggi keagamaan Islam di Provinsi Bengkulu dalam implementasi kurikulum yang mengacu pada Kerangka Kualifi kasi Nasional Indonesia (KKNI), tenaga pengajarnya, serta sarana dan prasarana. Penelitian ini merupakan penelitian kualitatif menggunakan desain penelitian studi kasus dengan teknik pengumpulan data menggunakan wawancara, observasi dan dokumentasi. Teknik analisis data dengan reduksi data, penyajian data dan penarikan kesimpulan/ verifi kasi. Hasil penelitian ini menggambarkan bahwa kesiapan perguruan tinggi keagamaan Islam di Provinsi Bengkulu implementasi kurikulum yang mengacu pada KKNI tergolong belum siap, hal ini dapat di lihat dari beberapa indikator bahwa 1). Steckholder belum pernah mengikuti workshop, pelatihan atau diklat tentang penyusunan kurikulum berbasis KKNI, 2). Belum pernah mendapatkan sosialisasi mengenai kurikulum yang mengacu kepada KKNI, dan 3). Belum mempunyai panduan penyusunan kurikulum tentang KKNI. Kesiapan dosen dalam implementasi kurikulum yang mengacu pada KKNI di perguruan tinggi keagamaan Islam di Provinsi Bengkulu juga tergolong belum siap, hal ini dapat di lihat dari kurangnya pemahaman dosen-dosen tentang kurikulum yang mengacu kepada KKNI, sistem pengajaran yang di sampaikan oleh para dosen masih cenderung secara konvensional. Dari segi sarana dan prasarana dapat di katakan sudah cukup memadai dalam implementasi kurikulum yang mengacu kepada KKNI.
PERAN HUMAS DALAM MEMBANGUN CITRA SEKOLAH BERBUDAYA DI MADRASAH ALIYAH NEGERI 1 PALEMBANG (Studi kasus terhadap peran humas dalam membangun citra di MAN 1 Palembang)
Authors: Annur Saipul , Audina Ulia
Published: July 2020

Peran Humas Dalam Membangun Citra Sekolah Berbudaya Di Madrasah Aliyah Negeri 1 Palembang (Studi Kasus Terhadap Peran Humas Dalam Membangun Citra Di MAN 1 Palembang). Penelitian ini bertujuan untuk mengetahui dan mendeskripsikan tentang peran humas dalam membangun citra sekolah berbudaya di Madrasah. Metode yang digunakan dalam penelitian ini adalah metode deskripsi kualitatif untuk mengetahui peran Humas dalam membangun citra sekolah. Teknik pengumpulan data menggunakan teknik observasi, wawancara dan dokumentasi yang digunakan untuk menghimpun data tentang keadaan peran humas dan lain-lain. Peran humas dalam membangun citra sekolah berbudaya di Madrasah sudah menjalankan peran dan fungsinya dalam katagori cukup baik. Hal tersebut digambarkan dengan kontribusi Waka Humas maupun staf kehumasan dalam perumusan rencana serta pelaksanaan program Humas, peran Humas dalam membangun citra sekolah berbudaya di Madrasah Aliyah Negeri 1 Palembang yaitu adanya dukungan yang tinggi dari pihak pimpinan Madrasah, adanya komunikasi yang baik antar anggota Humas sehingga dapat berbagi informasi mengenai berita-berita yang ada di Madrasah maupun di luar Madrasah. Faktor penghambat peran Humas dalam membangun citra sekolah berbudaya adalah belum maksimalnya sosialisasi dan terbatasnya waktu yang dimiliki pihak Humas karena berperan ganda, selain sebagai Humas juga menjadi guru mata pelajaran.
PEMBAHARUAN HUKUM KELUARGA DI DUNIA ISLAM (Analisis Terhadap Regulasi Poligami dan Keberanjakannya dari fikih)
Authors: Andiko Toha
Published: July 2020

Tulisan ini menjelaskan regulasi poligami di lima negara Islam, khususnya tentang sebab-sebab kebolehan dan pelarangannya. Metode yang umum digunakan untuk pembaruan hukum keluarga di lima negara tersebut, tampaknya lebih dominan menggunakan metode extra-doctrinal reform dan sedikit dengan intra-docrinal reform, itupun masing-masing dengan modifikasi dan tekanan yang berbeda-beda. Secara vertikal, keberanjakan hukum keluarga pada kelima negara di atas dari kitab-kitab fikih mazhab cukup tinggi. Yang tertinggi adalah Iran, disusul Malaysia, lalu Somalia, dan terakhir Indonesia. Semakin rinci dan banyak sebab yang disebutkan untuk kebolehan poligami karena keadaan istri, berarti semakin longgar dan besar peluang poligami. Sedangkan Tunisia melarang poligami secara mutlak.