bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Senam Nifas Terhadap Kecepatan Involusi Uterus Pada Ibu Nifas Di PMB Hj. Nining Mutbaiyah Pamarayan Kabupaten Serang Tahun 2021
Authors: Setianingsih Lilis Zuniawati , Halimatusyadiah Leni
Published: July 2023

Penelitian ini bertujuan untuk mengetahui pengaruh senam nifas terhadap kecepatan proses involusi pada ibu postpartum di PMB Hj. Nining Mutbaiyah tahun 2021. Desain Penelitian ini adalah pra eksperimen dengan posttest only with control group design, dengan responden berjumlah 42 ibu post partum normal di PMB Hj. Nining Mutbaiyah, terdiri dari 21 ibu yang melakukan senam nifas (kelompok responden eksperimen) dan 21 ibu yang tidak melakukan senam nifas (kelompok responden kontrol). Penjaringan datanya menggunakan observasi, sedangkan analisis datanya menggunakan rumus komparasi non-parametris Mann-Whitney. Hasil Penelitian: Kecepatan involusi uterus pada ibu nifas yang melakukan senam nifas mayoritas berada pada kategori cepat sebanyak 16 orang (76,19%). Kecepatan involusi uterus pada ibu nifas yang tidak melakukan senam nifas mayoritas berada pada kategori tepat sebanyak 16 orang (76,19%); Terdapat pengaruh dari senam nifas terhadap kecepatan involusi uterus pada ibu nifas di PMB Hj. Nining Mutbaiyah, dengan perolehan nilai Mann-Whitney U = 66,000 (p = 0,0001 < 0,05). Kesimpulan: Terdapat pengaruh dari senam nifas terhadap kecepatan involusi uterus pada ibu nifas.
Faktor-Faktor yang Berhubungan dengan Kejadian Mastitis pada Ibu Post Partum yang Menyusui di Wilayah Kerja Puskesmas Banjar Agung Kota Serang Tahun 2021
Authors: Lustiani Ika , Sari Dwinda
Published: July 2023

Penelitian ini mengetahui faktor-faktor yang berhubungan dengan kejadian mastitis pada ibu post partum yang menyusui di wilayah kerja Puskesmas Banjar Agung  Kota Serang tahun 2021. Metode penelitian bersifat deskriptif analitik dengan desain cross sectional. Populasi adalah seluruh ibu post partum yang menyusui sebanyak 325 ibu menyusui di Puskesmas Banjar Agung Kota Serang Tahun 2021 (Data Primer). Teknik sampling yang digunakan adalah tehnik Quota Sampling yaitu teknik yang dilakukan dengan cara menetapkan sejumlah anggota sampel secara quotum atau jatah. Data umur, pendidikan, paritas dan pekerjaan diperoleh dari wawancara dengan kuesioner. Analisis Bivariat dilakukan dengan Chi-Square. Dari hasil penelitian dapat disimpulkan bahwa Ada hubungan antara umur dengan Kejadian Mastitis pada ibu post partum yang menyusui. ada hubungan antara pendidikan dengan Kejadian Mastitis pada ibu post partum yang menyusui, ada hubungan antara paritas dengan Kejadian Mastitis pada ibu post partum yang menyusui, ada hubungan antara pekerjaan dengan Kejadian Mastitis pada ibu post partum yang menyusui.
Formulasi Sediaan Pemerah Pipi Sari Kulit Buah Naga Merah (Hylocereus polyrhizus), dan Sari Kunyit (Curcuma domestica L) dalam Bentuk Stick
Authors: Nurmay Stiani Sofi , Ayuni Eka Sirly , Kurnia Nia Marlina , Yusransyah Yusransyah
Published: July 2023

The purpose of this study was to make rouge using natural dyes on the skin of red dragon fruit (Hylocereus polyrhizus) and turmeric (Curcuma domestica L). Natural dyes are obtained by smoothing the skin of red dragon fruit (Hylocereus polyrhizus) and turmeric extract (Curcuma domestica L). cheek coloring formula made using a combination of red dragon fruit peel juice (Hylocereus polyrhizus) and turmeric juice (Curcuma domestica L) with concentrations of 10% and 2% (Formula I), 20% and 2.5% (Formula II), 30% and 3% (Formula III). The results of the study with a concentration of 10%: 2%, 20%: 2.5% and 30%: 3% produced a homogeneous blush, aroma, color and good smearing power. pH 4-7, rouge preparations do not cause a reaction (irritation) when applied and the concentration that is preferred by panelists is formula III (30%: 3%). The conclusion of this study is that the combination of red dragon fruit peel juice (Hylocereus polyrhizus) and turmeric juice (Curcuma domestica L) can be used as a natural dye, increasing the concentration of the juice used to increase the dark color pigment in the preparation.
 
Tujuan penelitian ini adalah untuk membuat pemerah pipi dengan memanfaatkan pewarna alami pada kulit buah naga merah (Hylocereus polyrhizus) dan kunyit (Curcuma domestica L). Pewarna alami diperoleh dengan cara menghaluskan kulit buah naga merah (Hylocereus polyrhizus) dan kunyit (Curcuma domestica L). formula pewarna pipi yang dibuat menggunakan zat kombinasi dari sari kulit buah naga merah (Hylocereus polyrhizus) dan sari kunyit (Curcuma domestica L) dengan konsetrasi 10% dan 2% (Formula I), 20% dan 2,5% (Formula II), 30% dan 3% (Formula III). Hasil penelitian dengan konsentrasi 10% : 2%, 20% : 2,5% dan 30% : 3% menghasilkan pemerah pipi yang homogen, aroma, warna dan daya oles yang baik. pH 4-7, sediaan pemerah pipi tidak menimbulkan reaksi (iritasi) saat dioleskan dan konsentrasi yang banyak disukai panelis adalah formula III dengan konsentrasi 30% : 3%. Kesimpulan dari penelitian ini adalah kombinasi sari kulit buah naga merah (Hylocereus polyrhizus) dan sari kunyit (Curcuma domestica L) dapat digunakan sebagai pewarna alami, semakin tinggi konsentrasi ekstrak yang digunakan maka semakin gelap pigmen warna pada sediaan.
The Influence of Brand Image and Price on Toyota Avanza Car Purchasing Decision
Authors: Bakri Muhammad
Published: July 2023

This study intends to investigate the impact of Brand Image and Price on Purchasing Decisions for Toyota Avanza Automobiles at PT Hadji Kalla Urip Sumoharjo Branch Makassar. 76 respondents were gathered using primary data collected from 311 consumers of Toyota Cars on Toyota Avanza Cars at PT Hadji Kalla Urip Sumoharjo Branch Makassar. The results of the questionnaire have been evaluated for their validity and reliability, as well as for the classical assumptions of normality and multicollinearity. The method for analyzing data employs multiple regression techniques. Brand Image and Price have a positive and significant influence on the decision to purchase a Toyota Avanza automobile at PT Hadji Kalla Urip Sumoharjo Branch Makassar, as demonstrated by the research findings.
Entrepreneurship Training as A Form of Business Development for The People of Sanrobone Village, Takalar Regency
Authors: Bahari Andi Faisal
Published: July 2023

Technological advances have an impact on all aspects of human life.   The economy has not got rid of the impact of technology.  Technology   provides a variety of facilities for the economy, which undoubtedly greatly supports the existing economic system. One of them is the role of technology in business, which is now known as e-commerce in developing the business further.  In today's digital age, student awareness, especially in remote villages, has not been effective in maximizing the use of technology, and most students have smartphones.  Although using Internet access is quite possible for a person to interact or even trade in the world of online technology (Internet), it can become a new land for entrepreneurs young to promote and market their products.  It is hoped that the socialization of this service team can be the first step for students, especially those in the village, and create new entrepreneurs.  The purpose of implementing this socialization is to allow students to have an account in the field of online trading and operate separately.
Science and Technology for the Community Compilation of Financial Statements Based on SAK ETAP
Authors: Subhan Subhan
Published: July 2023

The PkM program developed is the implementation of preparing financial reports based on Entity Financial Standards Without Public Accountability (SAK ETAP). SAK ETAP is a standard issued by the Indonesian Accounting Standards Board (DSAK) that must be applied by all companies. The method used in implementing this PkM activity program is the provision of counseling and training to partner employees using direct methods for transactions that occur in company activities. The results of the activity are expected that partner employees can know and carry out the preparation of financial reports based on Financial Accounting Standards for Entities Without Public Accountability (SAK ETAP).
Impact of Regional Revenue and Expenditure Budgets and Economic Growth on the Human Development Index
Authors: Maknun Mappaujung
Published: July 2023

This study aims to examine and analyze the Influence of Expenditure Budget and Economic Growth on the Human Development Index in Makassar City. The data sources for this research were taken from the Regional Financial and Asset Management Agency (BPKAD) and the Central Bureau of Statistics (BPS) for Makassar City. The data collection technique uses documentation in the form of Budget Realization Reports and Gross Domestic Product based on Current Prices according to Expenditures from 2010-2019. The data that has been collected will be analyzed with several stages of testing, including descriptive statistical tests, classic assumption tests consisting of (normality test, multicollinearity test, heteroscedasticity test, autocorrelation test), and testing of all hypotheses which will be proven through a coefficient of determination test, test partial (t test) and simultaneous test (f test). The results of the research that has been done state that the APBD variable has a very weak effect because it has no real effect and is not significant to the Human Development Index in Makassar City. While the variable Economic Growth has a positive and significant effect on the Human Development Index, which means that if Economic Growth is increased it will increase the value of the Human Development index in Makassar City
Intellectual Capital and Corporate Social Responsibility on Stock Returns
Authors: Ameliana Yana , Lantara Niniek F , Arfah Aryati , Arif Muhammad
Published: July 2023

This study aimed to determine the effect of intellectual capital and corporate social responsibility on stock returns in manufacturing companies listed on the Indonesia Stock Exchange. The type of data used in this study is quantitative data in the form of values or numbers obtained from financial reports. The source of data in this research is secondary data. The population in this study were all manufacturing companies listed on the Indonesia Stock Exchange, totaling 17 companies. Using a purposive sampling method, the total sample in this study is 51 data from 17 companies. The data in this study will be tested with several stages of testing, namely descriptive statistical tests, classic assumption tests (normality test, heteroscedasticity test, multicollinearity test), and testing of all hypotheses through the partial test (t test), simultaneous test and coefficient test determination. The results of this study indicate that intellectual capital and corporate social responsibility have a positive and significant effect on stock returns in manufacturing companies listed on the Indonesia Stock Exchange (IDX). This means that the increasing value of intellectual capital and corporate social responsibility, the stock return will also increase.
Effect of Working Capital Effectiveness and Growth Opportunity on Profitability
Authors: Sari Ratna
Published: July 2023

This study aimed to analyze the effect of cash turnover, accounts receivable turnover, inventory turnover and Growth Opportunity on Manufacturing Companies' Profitability on the Indonesia Stock Exchange. The type of data used in this study is quantitative data in the form of numbers in the form of financial reports on manufacturing companies listed on the Indonesia Stock Exchange in the period 2017 -2020 . Data sources in research are secondary data, namely in written form or company documents. The data in this study will be tested with several stages of testing, namely descriptive statistical tests, classic assumption tests (normality test, heteroscedasticity test, multicollinearity test, autocorrelation test), and testing all hypotheses through the partial test (t test) and coefficient test determination. Based on hypothesis testing this study, it shows that the variable cash turnover, accounts receivable turnover, and inventory turnover positively and significantly affect profitability proxied by return on assets (ROA). In contrast, the growth opportunity variable has no significant effect on profitability proxied by return on assets (ROA)
Unaffected by Working Capital, Liquidity, and Solvency Profitability: Evidence from Indonesia
Authors: Rahman Abdul
Published: July 2023

This study aims to determine the influence of Working Capital Turnover, Current Ratio, and Debt to Asset Ratio on the Return on Assets of Food and Beverage Companies listed on the Indonesia Stock Exchange. This study's sample comprises Indonesia Stock Exchange (IDX) companies. This study's samples contained ten large corporations in the food and beverage manufacturing industry chosen through systematic sampling. This study utilizes secondary data extracted from the website of the Indonesia Stock Exchange about the financial statements of food and beverage companies. This investigation used multiple linear analysis methods employing the WCT, CR, and DAR ratios. In addition, data analysis is performed, which includes descriptive statistical analysis, validity tests, reliability tests, normality tests, multicollinearity tests, heteroscedasticity tests, and hypothesis testing via the coefficient of determination test, t-test, and f-test. Working Capital Turnover has a negative and insignificant influence on Return On Asset, Current Ratio has a negative and significant impact on Return On Asset, and Debt To Asset Ratio has a positive and insignificant effect on Return On Asset, according to the partial test results.
Implications of Service and Product Attributes on Customer Loyalty
Authors: Haris Abdul
Published: July 2023

The research objectives are to determine the effect of service quality on customer loyalty at KFC Pengayoman in Makassar. To assess the impact of product attributes on customer loyalty at KFC Pengayoman in Makassar. To find out whether, among the service quality variables and product attribute variables, it is suspected that the product attribute variable has a more dominant effect on customer loyalty at KFC Pengayoman in Makassar. The data collection method in this study is to use field research. Researchers go directly to the object of research to obtain the data needed. The techniques used are observation, questionnaires (questionnaires), and library data. This study's types and data sources come from primary and secondary data. Preliminary data is obtained from respondents, namely people who go and buy KFC Pengayoman Products in Makassar City, by giving several questions as research instruments. Secondary data, namely data obtained to complement primary data in the form of documents or reports that can support the discussion about this research. The results showed that service quality variables significantly affected customer loyalty. Product attribute variables have no significant effect on customer loyalty. Service quality is the dominant variable affecting customer loyalty at KFC Pengayoman Makassar because it has a higher coefficient value and a better significance level than other variables.
Relationship between Working Capital Elements and Company Profitability
Authors: Arifani Arifani
Published: July 2023

This study aimed to determine the effect of working capital elements consisting of cash turnover, accounts receivable turnover, inventory turnover, and current debt turnover on profitability in food and beverage companies listed on the Indonesia Stock Exchange. The population in this study are food and beverage companies listed on the Indonesia Stock Exchange. Using the purposive sampling method, the total sample in this study was ten companies. The type of data used in this study is quantitative data in the form of values or numbers obtained from financial statements. The data source in this study is secondary data. The data in this study will be tested with several stages of testing, namely, the classic assumption test consisting of (the normality test, autocorrelation test, multicollinearity test), and testing all hypotheses through the partial test (t test), simultaneous test and determination coefficient test. This study's results indicate that cash and inventory turnover positively but insignificant affect profitability (ROA). At the same time, the variables of accounts receivable turnover and current debt turnover have a negative and insignificant impact on profitability (ROA).
The Role of Internal Auditor of Government Companies: Perceptions of the Auditee
Authors: Fuada Nurul
Published: July 2023

This study aims to determine the auditee's perception of the role of internal auditors in one of the government companies, namely PT. PLN (Persero) Sulselrabar Main Unit. The research data was obtained from a questionnaire (primary) on employees (as auditees) which were distributed to 30 respondents. There are three variable dimensions used, namely the role of internal auditors as supervisors, consultants, and catalysts. Based on the research results it is known that the role of internal auditors as supervisors has an average value (mean) ranging from 2.87 to 3.37, while for the role of internal auditors as consultants has an average value ranging from 3.00 to 3.40, and for the role of internal auditors as a catalyst has an average value ranging from 2.90 to 3.27. So it can be concluded that the auditee's perception indicates that the role of the internal auditor at PT. PLN (Persero) Main Unit for Sulselrabar Region has been quite effective in its implementation. This can be seen from all of these variables the respondent (auditee) gives a positive perception of the role of the internal auditor
The Influence of Task Complexity, Independence and Integrity on Internal Audit Quality
Authors: Ahmad Hamzah
Published: July 2023

Penelitian ini bertujuan untuk menguji dan mengetahui pengaruh kompleksitas tugas, independensi dan integritas terhadap kualitas audit internal pada Inspektorat Kabupaten Bantaeng. Penelitian ini merupakan penelitian kuantitatif dengan pendekatan deskriptif. Populasi dalam penelitian ini adalah aparat inspektorat Kabupaten Bantaeng yang berjumlah 35 orang. Metode penentuan sampel yang digunakan dalam penelitian adalah sensus sampling, dengan metode pengolahan data menggunakan analisis regresi linear berganda. Data yang digunakan dalam penelitian ini merupakan data primer yang dikumpulkan dengan membagikan kuesioner secara langsung kepada responden. Hasil penelitian menunjukkan bahwa kompleksitas tugas berpengaruh negatif dan signifikan terhadap kualitas audit internal sementara independensi dan integritas berpengaruh positif dan signifikan terhadap kualitas audit internal.
Professional Skepticism, Audit Experience, Time Pressure and Fraud Detection
Authors: Subhan Subhan
Published: July 2023

The purpose of this study was to identify and analyze the influence of professional skepticism, audit experience, and time pressure on fraud detection at the Selayar Islands District Inspectorate. The population in this study were all employees working at the Inspectorate of the Selayar Islands Regency totaling 48 people. The sampling technique for this study used a purposive sampling technique. The data used in this study are primary data collected by distributing questionnaires to all respondents, with data analysis techniques that will be carried out namely validity and reliability tests, classical assumption tests, multiple linear regression analysis and hypothesis testing consisting of partial tests (t test ) and simultaneous test (test f). The results showed that professional skepticism and audit experience had a positive effect on fraud detection at the Selayar Islands District Inspectorate. Meanwhile, time pressure has a negative effect on the detection of fraud at the Inspectorate of the Selayar Islands Regency.
E-Commerce Tax Implementation: A Study on South Korean Product Online Shop Business
Authors: Zahirah Zahirah , Pramukti Andika , Arsyad Muhammad
Published: July 2023

Regarding the growing demand for South Korean goods among Indonesian entrepreneurs. E-commerce services provide a convenient and quick way for them to sell these items via the internet, bypassing the need for a physical encounter between the buyer and seller. The study's goal is to examine how well South Korean internet store owners comprehend e-commerce tax. A qualitative descriptive approach was taken for this investigation. Primary sources were employed for this study. Google Forms were used to collect data from a set sample of respondents, and online interviews were conducted virtually. Main findings this study, some online store owners selling South Korean products are already familiar with e-commerce taxes, while others are still in the dark about them due to a lack of socialization from the tax office.
Towards Optimal Taxes: Impact of Tax Extensification and Intensification on Individual Income Tax Receipts
Authors: Pasolo Muhammad Ridhwansyah , Ermawati Yana , Sonjaya Yaya , Sumartono Sumartono
Published: July 2023

This study seeks to investigate the impact of tax extension and intensification on personal income tax collections. The sample was selected using a specific procedure to ensure that it was representative of the population; the sample size was 100 respondents. The data source employed is primary data, i.e., data collected directly from respondents via questionnaire by researchers. The methodology employed in this study is multiple linear analysis. In addition, descriptive statistical analysis, validity tests, reliability tests, normality tests, heteroscedasticity tests, multicollinearity tests, and hypothesis testing with the coefficient of determination test, t test, and f test were performed on the data. The results of the analysis indicate that Tax Extensification has a positive and significant impact on Individual Income Tax Receipts, while Tax Intensification has a similar effect.
William S. Campbell. Romans: A Social Identity Commentary
Authors: Rodríguez Rafael
Published: July 2023

No abstract is available.
Order Reconfiguration under Width Constraints
Authors: Arrighi Emmanuel , Fernau Henning , De Oliveira Oliveira Mateus , Wolf Petra
Published: July 2023

In this work, we consider the following order reconfiguration problem:
Given a graph $G$ together with linear orders $\omega$ and $\omega'$
of the vertices of $G$, can one transform $\omega$ into $\omega'$ by a
sequence of swaps of adjacent elements in such a way that, at each time step, the resulting linear
order has cutwidth (pathwidth) at most $k$? We show that this problem
always has an affirmative answer when the input linear orders $\omega$ and $\omega'$
have cutwidth (pathwidth) of at most
$k/2$. This result also holds in a weighted setting.
Using this result, we establish a connection between two apparently unrelated
problems: the reachability problem for two-letter string rewriting systems and the graph
isomorphism problem for graphs of bounded cutwidth. This opens an avenue for the study of
the famous graph isomorphism problem using techniques from term rewriting theory.
Innovative therapeutic applications in wound healing treatment
Authors:   University of Szeged Department of Dermatology and Allergology Albert Szent-Györgyi Medical Center, Bende Balázs , Lovászi Borbála , Szűcs Diána , Monostori Tamás , Kun-Varga Anikó , Shahram Parvaneh , Göblös Anikó , Veréb Zoltán
Published: July 2023

Even today, the treatment of wounds, especially chronic wounds, is still a major burden on healthcare. In addition to the many pharmaceutical and surgical interventions, the use of skin substitutes gains ground in this field. Skin substitutes can be considered as artificial tissues, they can help the skin to regenerate and they can model the main functions of the skin, but they have the disadvantage of being mechanically fragile and not durable. They do not contain all the cellular elements of the skin, often only the specific extracellular matrix proteins. New innovative applications aim at creating more complex skin substitutes, using artificial skin tissues created by three-dimensional tissue printing, not only for pre-clinical studies but also for clinical therapeutic use.
Milestones of electrochemotherapy
Authors:   University of Szeged Department of Dermatology and Allergology Albert Szent-Györgyi Medical Center, Kis Erika , Baltás Eszter , Ócsai Henriette , Csányi Ildikó , Ottlakán Aurél , Lázár György , Vass Gábor , Ágoston Dóra , Rózsa Petra , Bottyán Krisztina , Dalmády Szandra , Nagy András , Tóth-Molnár Edit , Oláh Judit
Published: July 2023

Electrochemotherapy is a widely used locoregional method for the treatment of superficial tumors with different histologies. During treatment, a chemotherapeutic drug, usually bleomycin, is electroporated into the tumor cells, resulting in an increased cytotoxic effect. Beyond its effectiveness, electrochemoterapy is a repeatable and minimally invasive intervention that induces few side effects. The application of electrochemotherapy is expanding with the treatment of deep seated, visceral and benign tumors, and intensive research is in progress in order to investigate its combination with modern systemic therapies.
Changes in the surgical treatment of melanoma malignum at the Department of Dermatology and Allergology University of Szeged over the last decade
Authors:   University of Szeged Department of Dermatology and Allergology Albert Szent-Györgyi Medical Center, Varga Ákos , Bende Balázs , Baltás Eszter , Németh István , Varga Erika , Vass Gábor , Kis Erika , Oláh Judit , Varga János , Kocsis Ádám
Published: July 2023

Based on large international multicentre trials sentinel lymph node biopsy was found clinically relevant in intermediate thickness melanomas, furthermore sentinel lymph node positivity proved to be the single most important factor in overall survival. However, there is an ongoing debate in the literature regarding the need of sentinel lymph node biopsy in thin (<1mm) and thick (>4mm) melanomas. We aimed to analyse the clinicopathologic predictors of SNB positivity and the possible advantages of the procedure.
Cutaneous pathological aspects of biological and targeted therapies in daily practice
Authors:   University of Szeged Department of Dermatology and Allergology Albert Szent-Györgyi Medical Center, Varga Erika , Horváth Zsófia , Németh István Balázs , Korom Irma
Published: July 2023

Biological and targeted therapies are the most up-todate treatment modalities in numerous inflammatory and neoplastic cutaneous diseases however they can induce adverse events. Among them skin adverse reactions are very frequent and can draw the attention to other organ’s involvement. Skin symptoms are variable and not specific for the causative agent. Lichenoid and maculopapulous reactions, psoriasiform dermatitis, autoimmune skin disease, vitiligo and granulomatous reaction can all be developed. In order to establish the proper histological diagnosis pathologist should be aware of the treatment and the possible skin symptoms caused by it. Authors describe such cutaneous adverse reactions through case presentations.
Advances in the treatment of psoriasis in the past twenty years
Authors:   University of Szeged Department of Dermatology and Allergology Albert Szent-Györgyi Medical Center, Kui Róbert , Kovács Réka , Nagy Géza , Baltás Eszter
Published: July 2023

Psoriasis vulgaris is one of the most common immune-mediated skin diseases with characteristic skin symptoms. Authors provide an overview of the advancement in the psoriasis treatment over the past twenty years. They discuss the therapeutic options and the latest developments in the field of topical therapy, phototherapy, small-molecule systemic drugs and revolutionary biological treatments.
Anorectal infections caused by sexually transmissible pathogens
Authors:   University of Pécs Medical School Department of Dermatology, Venereology and Oncodermatology, Rózsa Annamária , Bognár Máté , Kövesdi Dorottya , Kondor Ariella Edina , Moezzi Mehdi
Published: July 2023

The authors present the case of a 20-year-old male patient, who was refered to their department by his family doctor with suspected drug allergy. He had several proctological examinations in the last half year, because of a chronic intermittently bleeding anal fissure, which has been treated with analgesic rectal cream and wound healing gel. During physical examination multiple maculopapular rash all over the body, infiltrated brownish papules on the soles and purulent discharge on the pharyngeal wall were detected. Differential diagnosis included secondary syphilis, viral exanthema and drug eruption. The syphilis serological tests confirmed the diagnosis of secondary syphilis. The patient received benzathine-penicillin treatment. Due to the non-healing anal fissure pelvic MR was performed, which did not reveal definitive fistula. Further STI screening tests showed Neisseria gonorrhoeae infection of the anus and after ceftriaxon administration the patient’s anorectal symptoms healed. Our case emphasizes the importance of sexually transmitted co-infections.
Management of hydradenitis suppurativa in the clinical routine between 2013–2023 in the Department of Dermatology, Venereology and Oncodermatology, University of Pécs
Authors:   University of Pécs Medical School Department of Dermatology, Venereology and Oncodermatology, Kádár Zsolt , Durkot Patrícia , Kovács András L. , Németh Csongor , Horváth Zsuzsanna , Kinyó Ágnes
Published: July 2023

In the past 10 years, significant progress has been made in the treatment of hydradenitis suppurativa worldwide, including the Department of Dermatology, Venereology and Oncodermatology, University of Pécs. In our hydradenitis outpatient clinic, 100-120 patients a year have been treated in cooperation with dermatologist and surgeons. In mild cases topical treatment and deroofing technique is the first choice of therapy, in severe cases biological treatment and/or major surgical approaches are recommended. Based on the author’s experiences, deroofing surgeries resulted in a long-lasting improvement in mild cases, while in severe hydradenitis, wide excision shows final resolution of the disease
miR-252 targeting temperature receptor CcTRPM to mediate the transition from summer-form to winter-form of Cacopsylla chinensis
Authors: Zhang Songdou , Li Jianying , Zhang Dongyue , Zhang Zhixian , Meng Shili , Li Zhen , Liu Xiaoxia
Published: July 2023

Temperature determines the geographical distribution of organisms and affects the outbreak and damage of pests. Insects seasonal polyphenism is a successful strategy adopted by some species to adapt the changeable external environment.
Cacopsylla chinensis
(Yang & Li) showed two seasonal morphotypes, summer-form and winter-form, with significant differences in morphological characteristics. Low temperature is the key environmental factor to induce its transition from summer-form to winter-form. However, the detailed molecular mechanism remains unknown. Here, we firstly confirmed that low temperature of 10°C induced the transition from summer-form to winter-form by affecting the cuticle thickness and chitin content. Subsequently, we demonstrated that
CcTRPM
functions as a temperature receptor to regulate this transition. In addition, miR-252 was identified to mediate the expression of
CcTRPM
to involve in this behavioral transition. Finally, we found
CcTre1
and
CcCHS1
, two rate-limiting enzymes of insect chitin biosyntheis, act as the critical down-stream signal of
CcTRPM
in mediating this behavioral transition. Taken together, our results revealed that a novel signal transduction cascade mediates the seasonal polyphenism in
C. chinensis
. These findings not only lay a solid foundation for fully clarifying the ecological adaptation mechanism of
C. chinensis
outbreak, but also broaden our understanding about insect polymorphism.
Optogenetic stimulation of the locus coeruleus enhances appetitive extinction in rats
Authors: Lui Simon , Brink Ashleigh , Corbit Laura
Published: July 2023

Extinction is a specific example of learning where a previously reinforced stimulus or response is no longer reinforced, and the previously learned behaviour is no longer necessary and must be modified. Current theories suggest extinction is not the erasure of the original learning but involves new learning that acts to suppress the original behaviour. Evidence for this can be found when the original behaviour recovers following the passage of time (spontaneous recovery), or reintroduction of the reinforcement (i.e., reinstatement). Recent studies have shown that pharmacological manipulation of noradrenaline (NA) or its receptors can influence appetitive extinction, however, the role and source of endogenous NA in these effects is unknown. Here, we examined the role of the locus coeruleus (LC) in appetitive extinction. Specifically, we tested whether optogenetic stimulation of LC neurons during extinction of a food-seeking behaviour would enhance extinction evidenced by reduced spontaneous recovery in future tests. LC stimulation during extinction trials did not change the rate of extinction but did serve to reduce subsequent spontaneous recovery suggesting that stimulation of the LC can augment reward-related extinction. Optogenetic inhibition of the LC during extinction trials reduced responding during the trials where it was applied, but no long-lasting changes in the retention of extinction were observed. Since not all LC cells expressed halorhodopisn, is possible that more complete LC inhibition or pathway-specific targeting would be more effective at suppressing extinction learning. These results provide further insight into the neural basis of appetitive extinction, and in particular the role of the LC. A deeper understanding of the physiological bases of extinction can aid development of more effective extinction-based therapies.
Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states
Authors: Lin David Yin-wei , Kueffer Lauren E. , Juneja Puneet , Wales Thomas , Engen John R. , Andreotti Amy H.
Published: July 2023

Full-length BTK has been refractory to structural analysis. The nearest full-length structure of BTK to date consists of the autoinhibited SH3-SH2-kinase core. Precisely how the BTK N-terminal domains (the Pleckstrin homology/Tec homology (PHTH) domain and proline-rich regions (PRR) contain linker) contribute to BTK regulation remains unclear. We have produced crystals of full-length BTK for the first time but despite efforts to stabilize the autoinhibited state, the diffraction data still reveals only the SH3-SH2-kinase core with no electron density visible for the PHTH-PRR segment. CryoEM data of full-length BTK, on the other hand, provide the first view of the PHTH domain within full-length BTK. CryoEM reconstructions support conformational heterogeneity in the PHTH-PRR region wherein the globular PHTH domain adopts a range of states arrayed around the autoinhibited SH3-SH2-kinase core. On the way to activation, disassembly of the SH3-SH2-kinase core opens a new autoinhibitory site on the kinase domain for PHTH domain binding that is ultimately released upon interaction of PHTH with PIP
3
. Membrane-induced dimerization activates BTK and we present here a crystal structure of an activation loop swapped BTK kinase domain dimer that likely represents the conformational state leading to trans-autophosphorylation. Together, these data provide the first structural elucidation of full-length BTK and allow a deeper understanding of allosteric control over the BTK kinase domain during distinct stages of activation.
Avaliação da pesquisa contábil: os critérios dos principais periódicos brasileiros
Authors: Ferreira Mônica Aparecida , De Carvalho Hugo Leonardo Menezes , Lemes Sirlei , Farias Manoel Raimundo Santana
Published: July 2023

Considerando a fase de avaliação como importante etapa para o desenvolvimento científico da área e disseminação do conhecimento, este estudo teve como objetivo verificar os critérios estabelecidos pelos principais periódicos de Contabilidade no processo de avaliação das pesquisas desenvolvidas no Brasil. Para tanto, utilizou-se das instruções existentes a respeito do processo de avaliação dos estudos encaminhados nos sítios eletrônicos de todos os periódicos do estrato “A” Qualis/Capes, e um periódico de cada estrato inferior “B1”, “B2”e “B3”, da área de contabilidade. Assim, foi possível identificar os critérios, suas definições e realizar um comparativo entre os periódicos analisados, pelo que se demonstrou a falta de uniformização na transparência dos critérios, objetivos esperados por eles e um isomorfismo avaliativo pela replicação de critérios dos periódicos do estrato “A” Qualis/Capes pelas revistas do estrato “B1”, “B2”e “B3”. Esses resultados indicam, do ponto de vista epistemológico, um estágio ainda pouco maturado de evolução nesse quesito da avaliação, bem como contribui para uma melhor compreensão sobre a forma de ocorrência do processo de avaliação da pesquisa contábil brasileira, sob o enfoque dos critérios estabelecidos e expostos pelos periódicos na sua avaliação.
Neuroscience of Cognitive Adaptations in Space: A Review Article
Authors: . Harshita , Acharya Sourya , Shukla Samarth , Khare Mansi , Sachdev Ankita
Published: July 2023

The brain can continuously adapt to changing circumstances and environmental needs. Astronauts must adjust to a brand-new, weightless environment in space. Numerous space mission-specific environmental factors may impact neurocognitive function. Previous research has found that multiple psychomotor functions, such as postural control, accuracy of movement patterns, internal synchronisation, spatial orientation, and the neurological management of ongoing work, have deteriorated during space flight. Apart from disease and injury, toxic radiation, decompression mishaps, pharmaceutical side-effects, and excessive radiation exposure may all impact neurocognitive performance in space. Computerised exams and exercise equipment are just a couple of the instruments developed to evaluate and address these deficiencies and issues. How the brain will adjust to extended space travel is still a mystery. This review article thoroughly analyses state-of-the-art and upcoming challenges in cognitive neuroscience in space, from analog missions and computer simulations to orbit around the Earth and beyond. Thus; the aim of this review is to provide a better understanding of the various phases that our brain undergoes while exposed to entirely different environments.
Treatment Modalities of Cutaneous and Genital Warts: A Narrative Review
Authors: Pugalia Nidhi , Singh Adarsh Lata , Chandak Meenakshi
Published: July 2023

Human Papillomavirus (HPV) are non enveloped Deoxyribonucleic Acid (DNA) viruses, sized between 50-55 nm, that form two distinct groups to cause epithelial proliferation at cutaneous and mucosal surfaces, which are mostly benign. With more than 100 different HPV types, estimated 30-40 strains affect human genital tract. Of which, 16, 18, 31, 33, 35, 39, 45, 51, 52, and 5 are the oncogenic (high-risk) types associated with cervical, vulvar, vaginal, and anal cancers, and 6, 11, 40, 42, 43, 44, and 54 are non oncogenic (low-risk) types and are associated with genital warts. HPV 6 and 11 are more commonly associated with genital warts and are also responsible for approximately 90% of these lesions. Despite a series of modalities available to treat HPV, that range from topical to immunotherapeutic modalities to surgically destructive procedures, there is no promising, stand-alone modality which still is a cause of dilemma for Dermatologists while treating warts. The present article reviews all the treatment modalities commonly applied in practice and also the areas less explored by their level of evidences.
A Case of Renal Sarcoidosis: A Diagnostic Dilemma
Authors: Bhagavath Aravind , Pramod GR , Nataraju Kamalesh Tagadur , Reddy Srimannarayan
Published: July 2023

Sarcoidosis is a multi-system disease of unknown aetiology, characterised by non-caseating granulomas. It can involve any organ in the body, but commonly affects the lungs and lymph nodes. The worldwide prevalence of sarcoidosis is 20-60 per/100,000 and people, while in India, it is 61.2 per 100,000. The probable cause is an inflammatory response triggered by various environmental agents in genetically sensitive individuals. Approximately one-third of patients with sarcoidosis remain asymptomatic. Typical symptoms include non-specific pulmonary symptoms such as cough, dyspnoea and chest pain. Cutaneous or ocular manifestations may include malar rash, erythema nodosum, keratoconjunctivitis, anterior uveitis and chorioretinitis. The presence of hilar lymphadenopathy on chest X-ray is highly suggestive of sarcoidosis. In this case, a 68-year-old female patients, presented with complaints of anorexia and fatigue for the past three months. She was found to have anaemia, hypercalcaemia, and abnormal renal function. Abdominal ultrasonography (USG) showed normal findings. The patient was initially evaluated for Tuberculosis (TB) and started on empirical Anti-Tubercular Therapy (ATT). However, as the patient did not show any improvement, further evaluation was conducted, leading to a diagnosis of sarcoidosis. Treatment options for sarcoidosis include systemic steroids, immunosuppresants, and cytotoxic drugs. Biologics such as anti-Tumour Necrosis Factor (TNF) agents (etanercept, golimumab, and infliximab) have also been considered in the treatment. Sarcoidosis can present a diagnostic dilemma as seen in this patient who initially had features resembling disseminated TB. This highlights the importance of strong clinical suspicion by the treating physician and thorough evaluation.
Complementary Value of Tissue Doppler Imaging in Dobutamine Stress Echocardiography: A Prospective Cohort Study
Authors: Kumary V Sudha , Pillai Jayaprakash Kesava , Misiriya KJ Raihanathul
Published: July 2023

Introduction: In patients with Coronary Artery Diseases (CAD), the presence of viable myocardium predicts the recovery of Left Ventricular (LV) systolic function after revascularisation. The identification of myocardial viability during dobutamine stress echocardiography is subjective and with observer bias. Tissue Doppler Imaging (TDI) echocardiography has opened new possibilities for non-invasive quantification of myocardial function by directly interrogating myocardial velocity with high temporal and spatial resolution. Aim: To determine the baseline regional myocardial and mitral annular Maximum Systolic Velocities (MSV) in patients with LV dysfunction and to compare the MSV values in viable and nonviable myocardium. Materials and Methods: In this prospective Cohort study, TDI of regional and annular LV myocardial velocities was performed at the baseline (at rest) in 352 patients with CAD and LV dysfunction who were referred for Dobutamine stress Echocardiography. Viability assessment by 2 Dimensional (2D) methods was done simultaneously using routine Dobutamine stress protocol. Patients were grouped in two groups based on the presence or absence of viability with 2D stress echocardiography. TDI velocities were compared in the two groups of patients with and without myocardial viability. Measurements of regional wall thickness, Ejection Fraction(EF) and Wall Motion Score Index (WMSI) were done to assess the regional and global LV function in these patients. Those patients who underwent revascularisation were subsequently assessed for functional recovery by 2D and TDI echocardiography before discharge from the hospital. Analyses were conducted using Statistical Package for Social Sciences(SPSS) version 16.0. Results: Among 352 patients studied (124 females and 228 males), mean age 58 years (range 36 to 75 years). A total of 243 patients (69%) with viable myocardium as per 2D echocardiography had higher cut-off Baseline Regional Maximum Systolic Velocity (BRMSV) >0.03 m/s and baseline mitral annular systolic velocity >0.06 m/s with high sensitivity and specificity compared to patients with severe contractile dysfunction and non-viable myocardium. Conclusion: Tissue doppler parameters like regional myocardial systolic and mitral annular velocities have shown significantly higher cut-off values in those patients with ischaemic and viable myocardium compared to non-viable myocardium.
Correlation between Temporomandibular Joint Disorders, Sleep Quality and Stress among Dental Students: A Cross-sectional Study
Authors: Gaikwad Shamali , Waingade Manjushri , Medikeri Raghavendra S , Jangam Daya K
Published: July 2023

Introduction: Dental students are subjected to high levels of stress during their academic performance. The quality of sleep could also be affected in those with increased stress levels. Stress and sleep quality could be considered as risk factors in Temporomandibular Joint Disorders (TMD). Identification of the risk factors in TMD at the initial stages can lead to minimising the long term effects. Aim: To investigate the relationship between TMD symptoms, sleep quality and stress among dental students. Materials and Methods: A cross-sectional questionnairebased survey was conducted in the Department of Oral Medicine and Radiology, Sinhgad Dental College and Hospital, Pune, Maharashtra, India, from November 2021 to December 2021 among 255 dental students. Fonseca Anamnestic Index (FAI) questionnaire was used for evaluation of TMD, while Perceived Stress Scale (PSS) and Pittsburgh Sleep Quality Index (PSQI) were used to assess stress scores and sleep quality, respectively. The students were surveyed to categorise them, if they were showing any symptoms of mild, moderate or severe TMD. Similarly the sleep quality and stress scores were assessed. The relationship between TMD with stress and sleep quality was also evaluated. Data analysis was done using International Business Machines (IBM) Statistical Package for Social Sciences (SPSS) version 26.0. Comparison of frequencies of scores of PSS, PSQI and FAI within groups was done using Chi-square test. Bivariate correlation between PSS/PSQI, PSS/ FAI ad FAI/PSQI was assessed using correlation coefficient. Results: Out of 255 participants, 182 were females and 73 were males. It was observed that 221 (86.7%) students reported moderate stress levels, 21 (8.2%) students showed mild and 13 (5.1%) subjects showed high stress levels. Temporomandibular symptoms were reported as mild, moderate and severe in 130 (51%), 21 (8.2%) and 9 (3.5%) students, respectively. A total of 229 (89.8%) students showed poor sleep quality and 26 (10.2%) students showed good sleep quality. Moderate stress was correlated with poor sleep quality and mild TMD. Conclusion: The stress levels were significantly correlated with sleep quality and TMD symptoms. Thus, increased stress and poor sleep may be considered as risk factors of TMD. However, longitudinal studies in large samples are required to determine the cause and effect relationships between sleep quality, stress levels and TMD.