bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of transverse momentum distributions in p−Pb interactions at 0.9 TeV and 5.02 TeV
Authors: Ali Q. , Ali Y. , Haseeb M. , Tabassam U. , Ajaz M. , Ullah S.
Published: September 2018

This work is aimed to investigate the transverse momentum ([Formula: see text]) distributions of primary charged particles produced in p[Formula: see text][Formula: see text]Pb collisions at [Formula: see text][Formula: see text]0.9 TeV and 5.02 TeV. In this perspective, we have considered the pseudorapidity [Formula: see text] regions of [Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text] and [Formula: see text] and the transverse momentum range of [Formula: see text]. In order to check the validity of simulation, we have compared the prediction of EPOS-1.99, EPOS-LHC and QGSJETII-04 models with the measurement of the [Formula: see text] distribution of ALICE experiment at [Formula: see text][Formula: see text]5.02 TeV for [Formula: see text], [Formula: see text], [Formula: see text], and with the CMS experiment for [Formula: see text]. We discovered that all the models overpredict the distribution of the experimental data for [Formula: see text][Formula: see text]5 GeV/c while presenting consistent result with each other at 0.9 TeV as well as 5.02 TeV. For [Formula: see text][Formula: see text]5 GeV/c, the models seem to be consistent with the experimental data where the EPOS-LHC describes both the ALICE and CMS data very well.
Equilibrium electric current of massive electrons with anomalous magnetic moments induced by a magnetic field and the electroweak interaction with matter
Authors: Dvornikov Maxim
Published: September 2018

We study the possibility of the existence of the electric current, formed by massive electrons and positrons, flowing along an external magnetic field. The charged fermions are supposed to have nonzero anomalous magnetic moments and electroweakly interact with background matter. The expression for the current is obtained on the basis of the exact solution of the Dirac equation in the corresponding external fields. We demonstrate that, in the state of equilibrium, such a current is vanishing for any characteristics of the electron–positron plasma as well as the external fields. Our results are compared with the recent findings of other authors.
Carbon nanoflakes as a promising anode for sodium-ion batteries
Authors: Zhu Xiaocui , Savilov S. V. , Ni Jiangfeng , Li Liang
Published: September 2018

The sharp increase in the cost of lithium resource has driven the research on sodium-ion batteries (SIBs) as sodium shares a similar electrochemical property as lithium. Carbonaceous materials are important anodes for rechargeable batteries, but the prevailing graphite only shows a limited activity towards sodium storage. Herein, we demonstrate that carbon nanoflakes serve as an efficient anode material for SIBs, exhibiting a stable capacity of 148[Formula: see text]mAh[Formula: see text]g[Formula: see text] over 600 continuous cycles at 150[Formula: see text]mA[Formula: see text]g[Formula: see text] and an excellent rate capability of 120[Formula: see text]mAh[Formula: see text]g[Formula: see text] at 1500[Formula: see text]mA[Formula: see text]g[Formula: see text]. More importantly, sodium storage in carbon nanoflakes exhibits a pseudocapacitive behavior, possibly due to their larger interlayer spacing and less-ordered structure vs. crystallized carbon.
Resistive switching effect enhanced by light irradiation in C/BaTiO3/C memory structure
Authors: Wu Liangchen , Chen Peng
Published: September 2018

The Ta/[C/BaTiO3/C]/Si device was obtained. The resistive switching (RS) behaviors of the Ta/[C/BaTiO3/C]/Si device are studied in the dark and under white-light illumination with various power densities. The results show that the device displays bipolar RS effect, which can be modulated by the white light. And the RS memory device shows biggish resistance ratio, which is more than 105 under white-light irradiation with a power density of 40[Formula: see text]mW/cm2, and the ratio can stabilize at nearly 71 cycles. This work is helpful for the optical control non-volatile memory.
Complex and thermodynamic properties of polar liquids using time domain reflectometry
Authors: Tabassum Shagufta , Pawar V. P.
Published: September 2018

The study of complex properties in a binary mixture of 1,2-dichloroethane (DE) and [Formula: see text]-methylformamide (NMF) polar liquids has been carried out in the frequency range of 10[Formula: see text]MHz to 30[Formula: see text]GHz for 11 different concentrations using time domain reflectometry technique at 283, 288, 293 and 298[Formula: see text]K temperatures. Complex property of binary liquids indicates the type of distribution of the dielectric relaxation time. The Bruggeman parameter gives the information about molecular interactions within binary polar liquids. Thermodynamic parameter deals with the passing of a dipole across a potential barrier which separates the minima of energy.
The susceptibility of glacigenic deposits to liquefaction under seismic loading conditions: a case study relating to nuclear site characterization in West Cumbria
Authors: Cross Martin , Attya Anass , Evans David J. A.
Published: September 2018

Previous research has established a chronostratigraphy of glacial/deglacial events together with a lithostratigraphical framework for the Quaternary deposits of the Sellafield area in West Cumbria. The glacial record is dominated by sediments and landforms laid down during the deglaciation of the Devensian ice sheet. The Quaternary deposits are characterized by complex sequences resulting from oscillating ice sheet margins, changing glacial lake and outwash environments, relative sea level changes and glacio-tectonic deformation. The resulting deposits comprise sequences which possess a wide range of grain size, shape and sorting; some are normally consolidated and have very low to low in situ density. An understanding of the geotechnical behaviour of these deposits is critical during geological site characterization studies for the design of new buildings and infrastructure on existing and proposed nuclear sites. The geotechnical engineering behaviour of a sequence of glacial deposits on the Sellafield nuclear site is evaluated together with their susceptibility to potential liquefaction under certain seismic load conditions. The evaluation identified that layers of very loose to loose deposits within the ice sheet marginal landsystem are particularly susceptible to liquefaction under specified seismic loading conditions that are required to be modelled by the UK Office for Nuclear Regulation (ONR).
A Survey on Compiler Autotuning using Machine Learning
Authors: Ashouri Amir H. , Killian William , Cavazos John , Palermo Gianluca , Silvano Cristina
Published: September 2018

Since the mid-1990s, researchers have been trying to use machine-learning-based approaches to solve a number of different compiler optimization problems. These techniques primarily enhance the quality of the obtained results and, more importantly, make it feasible to tackle two main compiler optimization problems: optimization selection (choosing which optimizations to apply) and phase-ordering (choosing the order of applying optimizations). The compiler optimization space continues to grow due to the advancement of applications, increasing number of compiler optimizations, and new target architectures. Generic optimization passes in compilers cannot fully leverage newly introduced optimizations and, therefore, cannot keep up with the pace of increasing options. This survey summarizes and classifies the recent advances in using machine learning for the compiler optimization field, particularly on the two major problems of (1) selecting the best optimizations, and (2) the phase-ordering of optimizations. The survey highlights the approaches taken so far, the obtained results, the fine-grain classification among different approaches, and finally, the influential papers of the field.
Sex- and Age-Specific Optimal Anthropometric Indices as Screening Tools for Metabolic Syndrome in Chinese Adults
Authors: Zhang Jia , Zhu Wenhua , Qiu Lifeng , Huang Lijuan , Fang Lizheng
Published: September 2018

Objectives. To compare the predictive ability of six anthropometric indices for identification of metabolic syndrome (MetS) and to determine their optimal cut-off points among Chinese adults. Methods. A total of 59,029 participants were enrolled. Body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), a body shape index (ABSI), body roundness index (BRI), and conicity index (CI) were measured. Receiver-operating characteristic curves analyses were performed to determine the discriminatory power of these indices for the identification of cardiometabolic risks and diagnosis of MetS. The differences in the area under the curve (AUC) values among the indices were evaluated. The Youden index was used to determine the optimal cut-off points. Results. WHtR and BRI exhibited the highest AUC values for identifying MetS and most cardiometabolic risk factors in both sexes, whereas ABSI showed the lowest AUC value. The general optimal cut-off points in women were 23.03 kg/m2 for BMI, 77.25 cm for WC, 0.490 for WHtR, and 3.179 for BRI; those in men were 24.64 kg/m2 for BMI, 87.25 cm for WC, 0.510 for WHtR, and 3.547 for BRI. The AUC values and cut-off points of the indices were also analyzed in each age and BMI category. Conclusions. In Chinese adults, WHtR and BRI showed a superior predictive power for MetS in both sexes, which can be used as simple and effective screening tools for cardiometabolic risks and MetS in clinical practice.
Severe Preeclampsia, Antiphospholipid Syndrome, and Ulnar Artery Thrombosis in a Teenage Pregnancy: A Rare Association
Authors: Patabendige M. , Barnasuriya G. , Mampitiya I.
Published: September 2018

Antiphospholipid syndrome (APS) is associated with vascular thrombosis and pregnancy complications. It causes recurrent miscarriage and it is associated with other adverse pregnancy outcomes such as preterm delivery, intrauterine growth restriction, preeclampsia, and HELLP syndrome. Obstetric morbidity is one of the major manifestations of APS with a wide variety of clinical manifestations. This case describes a case of a severe preeclampsia in a 16-year-old primigravida at 29 weeks resulting in a caesarean delivery and subsequent finding of an ulnar artery thrombosis in postpartum period. APS was diagnosed on further investigations of her symptoms and signs.
Localized Increment and Decrement in the Total Electron Content of the Ionosphere as a Response to the April 20, 2018, Geomagnetic Storm
Authors: Sotomayor-Beltran Carlos
Published: September 2018

A moderate geomagnetic storm occurred on April 20, 2018. Using vertical total electron content (VTEC) maps provided by the Center for Orbit Determination in Europe, ionospheric responses to the geomagnetic storm could be identified in generated two-dimensional differential VTEC maps. During the day of the storm the enhancement of the equatorial ionization anomaly (EIA), product of the super-fountain effect was identified. A localized TEC enhancement (LTE) was also observed to the south of the EIA on April 20, 2018. It was also possible to visualize this LTE in a longitudinal section of the EIA as a third crest. The maximum increment of VTEC for the LTE was 204%. This LTE is quite unique because it happened during the expected solar cycle 24 and 25 minimum, and according to a previous study no LTE observation could be done for the last solar two-cycle minimum. The origin of the observed LTE is suggested to be partly product of the super-fountain effect. Finally, a localized TEC decrement (LTD) was observed towards the end of the day, April 20, 2018. Because this LTD consisted in the disappearance of the northern and southern crests of the EIA and this occurred during the recovery phase of the geomagnetic storm, it can be suggested that the LTD origin is due to the westward disturbance electric field. This mechanism was put forward by a past study that also analyzed the responses to a geomagnetic storm (the 2015 St. Patrick’s day storm), being one of the responses the inhibition of both crests of the EIA.
Smoking Ban in Psychiatric Inpatient Unit: An Iranian Study on the Views and Attitudes of the Mental Health Staff and Psychiatric Patients
Authors: Beyraghi Narges , Mazaheri Meybodi Azadeh , Jafarian Bahri Reyhaneh Sadat
Published: September 2018

Although the move to smoke-free mental health inpatient settings is an internationally common and popular trend, these policies are neither implemented nor supported by any national program in Iran. This study investigates the attitude of mental health staff and psychiatric patients toward smoking cessation in 2 psychiatric inpatient units (psychosomatic and adult general psychiatry) in the Taleghani general hospital in Tehran. One hundred and twenty participants of this cross-sectional study consist of 30 mental health staff and 90 psychiatric patients. An eight-item questionnaire was used for collecting information. Both staff and patients expressed a positive attitude towards smoking cessation. Patients favoured the implementation of these policies and expressed a more positive attitude towards the feasibility. Sixty-three percent of patients and 57% of staff were opposed to smoking in the units. Seventy percent of patients reported the smoke-free ban as a feasible policy compared to 45% of staff who did the same. The implementation of the smoke-free policy has more support in both staff and patients than the continuation of smoking in psychiatric units. There is a need for an ongoing education and training for mental health care providers, in order to have a successful implementation of smoke-free policy.
A Case of Renal Pelvic Cancer Complicated by Horseshoe Kidney Treated with RoboSurgeon Gasless Single-Port Retroperitoneoscopic Nephroureterectomy
Authors: Suzuki Hiroaki , Takemura Kosuke , Sakamoto Kazumasa , Kataoka Madoka , Ito Masaya , Nakanishi Yasukazu , Tobisu Ken-ichi , Koga Fumitaka
Published: September 2018

A 78-year-old man who had a horseshoe kidney (HSK) visited us because of gross hematuria and suspicious urine cytology. CT and MRI revealed a right renal pelvic tumor of 28 mm in diameter. He underwent gasless single-port retroperitoneoscopic nephroureterectomy with division of the isthmus via the right pararectal small incision using the RoboSurgeon system. Pathological diagnosis was invasive urothelial carcinoma, grade 3, pT3, pN0, LVI0, RM0. He was discharged from hospital on the 6th postoperative day without any perioperative complication. He has no evidence of disease clinically and radiologically 19 months after the operation. Only a few cases of upper tract urothelial carcinoma complicated by HSK treated with minimally invasive surgery have been reported in English literature. This is the first case successfully managed with RoboSurgeon gasless single-port retroperitoneoscopic nephroureterectomy.
CRISPR/Cas9 System: A Bacterial Tailor for Genomic Engineering
Authors: Lone Bilal Ahmad , Karna Shibendra Kumar Lal , Ahmad Faiz , Shahi Nerina , Pokharel Yuba Raj
Published: September 2018

Microbes use diverse defence strategies that allow them to withstand exposure to a variety of genome invaders such as bacteriophages and plasmids. One such defence strategy is the use of RNA guided endonuclease called CRISPR-associated (Cas) 9 protein. The Cas9 protein, derived from type II CRISPR/Cas system, has been adapted as a versatile tool for genome targeting and engineering due to its simplicity and high efficiency over the earlier tools such as ZFNs and TALENs. With recent advancements, CRISPR/Cas9 technology has emerged as a revolutionary tool for modulating the genome in living cells and inspires innovative translational applications in different fields. In this paper we review the developments and its potential uses in the CRISPR/Cas9 technology as well as recent advancements in genome engineering using CRISPR/Cas9.
Postpartum Depression and Risk Factors among Vietnamese Women
Authors: Do Thi Kim Ly , Nguyen Thi Thanh Huong , Pham Thi Thu Huong
Published: September 2018

Postpartum depression (PPD) places a burden on maternal health. PPD exerts a negative impact on mothers’ health and children’s life. The purpose of this research was to identify the prevalence of PPD and the risk factors contributing to PPD. Therefore, a cross-sectional quantitative study was conducted. 116 women were categorized into two groups. One category included new mothers who received scores of Edinburgh Postpartum Depression Scale (EPDS) 12 or more. The other category included mothers who received scores less than 12. Descriptive statistic and then binary logistic regression were also performed. For EPDS ≥ 12, the prevalence of PPD was 27.6% among new mothers during the first year after delivery. Level of education, diseases during pregnancy, being the first-time mothers, dissatisfaction about family, and limited communication and interaction with others were significant predictors of PPD.
Resectional One Anastomosis Gastric Bypass/Mini Gastric Bypass as a Novel Option for Revision of Restrictive Procedures: Preliminary Results
Authors: Noun Roger , Slim Rita , Chakhtoura Ghassan , Gharios Joseph , Chouillard Elie , Tohmé-Noun Carla
Published: September 2018

Background. Revisional surgery is becoming a common and challenging practice in bariatric centers. The aim of this study was to evaluate resectional one anastomosis gastric bypass/mini gastric bypass (R-OAGB/MGB) as a revisional procedure. Methods. From January 2016 to February 2017, data on 21 consecutive patients undergoing R-OAGB/MGB for weight loss failure after primary restrictive procedures were prospectively collected and analysed. Results. Mean age was 39 ± 12 years (18–65), and 11 (52.3%) were women. The mean operative time was 96.4 ± 20.9 min (range, 122–80), and the mean postoperative stay was 47.8 ± 7.4 hours (range, 36–73). There were no deaths and no procedure-related complications. The mean body mass index (BMI) decreased from 42.9 ± 6.5 at the time of R-OAGB/MGB to 28.5 ± 4 at the 12-month follow-up. At that time point, the mean percentage of BMI loss (%EBL) and the mean percentage of total body weight loss (%TWL) reached 81.6 ± 0.17% and 35 ± 0.01%, respectively. Conclusion. R-OAGB/MGB was technically straightforward, effective, and safe in this at-surgical risk population. R-OAGB/MGB should be added to the armamentarium of revisional bariatric procedures considering its technical aspects and the potential advantage on weight loss.
Viral and Nonviral Engineering of Natural Killer Cells as Emerging Adoptive Cancer Immunotherapies
Authors: Matosevic Sandro
Published: September 2018

Natural killer (NK) cells are powerful immune effectors whose antitumor activity is regulated through a sophisticated network of activating and inhibitory receptors. As effectors of cancer immunotherapy, NK cells are attractive as they do not attack healthy self-tissues nor do they induce T cell-driven inflammatory cytokine storm, enabling their use as allogeneic adoptive cellular therapies. Clinical responses to adoptive NK-based immunotherapy have been thwarted, however, by the profound immunosuppression induced by the tumor microenvironment, particularly severe in the context of solid tumors. In addition, the short postinfusion persistence of NK cellsin vivohas limited their clinical efficacy. Enhancing the antitumor immunity of NK cells through genetic engineering has been fueled by the promise that impaired cytotoxic functionality can be restored or augmented with the use of synthetic genetic approaches. Alongside expressing chimeric antigen receptors to overcome immune escape by cancer cells, enhance their recognition, and mediate their killing, NK cells have been genetically modified to enhance their persistencein vivoby the expression of cytokines such as IL-15, avoid functional and metabolic tumor microenvironment suppression, or improve their homing ability, enabling enhanced targeting of solid tumors. However, NK cells are notoriously adverse to endogenous gene uptake, resulting in low gene uptake and transgene expression with many vector systems. Though viral vectors have achieved the highest gene transfer efficiencies with NK cells, nonviral vectors and gene transfer approaches—electroporation, lipofection, nanoparticles, and trogocytosis—are emerging. And while the use of NK cell lines has achieved improved gene transfer efficiencies particularly with viral vectors, challenges with primary NK cells remain. Here, we discuss the genetic engineering of NK cells as they relate to NK immunobiology within the context of cancer immunotherapy, highlighting the most recent breakthroughs in viral vectors and nonviral approaches aimed at genetic reprogramming of NK cells for improved adoptive immunotherapy of cancer, and, finally, address their clinical status.
A New Trajectory Optimizing Method Using Input Shaping Principles
Authors: Zhao Pu , Zhou Yunfei , Zhou Rougang
Published: September 2018

Input shaping is an efficient control technique which has motivated a great number of contributions in recent years. Such a technique generates command signals that can manoeuvre flexible structures without exciting their vibration modes. This paper introduces a new trajectory optimizing method based on input‐shaping principles. The main characteristic of this method in comparison with traditional input‐shaping technique is the generating process of final trajectory. By adding reversion and postprocessing procedures before input shapers, time‐delay and most of the trajectory deviation can be removed. The improvement of the proposed method compared with a traditional method is evaluated by simulations. It will be shown that the proposed method leads to no time‐delay and highly decreased trajectory deviation and little change of robustness.
Magnetic-Guided Capsule Endoscopy in the Diagnosis of Gastrointestinal Diseases in Minors
Authors: Qian Yuting , Bai Tingting , Li Juanjuan , Zang Yi , Li Tong , Xie Mingping , Wang Qi , Wang Lifu , Shen Ruizhe
Published: September 2018

Objective. This study aimed at investigating the clinical value of magnetic-guided capsule endoscopy (MGCE) in the diagnosis of gastrointestinal diseases in minors. Methods. Eighty-four minor patients hospitalized in the pediatric department at Ruijin Hospital between June 2015 and January 2018 were enrolled for this study. Following bowel preparation, all patients underwent MGCE. The feasibility, safety, diagnostic yield, and sensitivity of MGCE were analyzed. Patients were followed up for more than 2 weeks. Results. The main indications for MGCE in minors were Crohn’s disease, gastrointestinal bleeding, and abdominal pain. The main causes of gastric disease were gastric inflammatory hyperplasia, exudative gastritis, and polyps. The most common small bowel diseases in minors were Crohn’s disease, Henoch-Schonlein purpura, and polyps. The diagnostic yield in the stomach and small intestine was 13.1% and 28.6%, respectively, and the sensitivity was 100% and 96.0%, respectively. No adverse events occurred. Conclusion. MGCE is a safe, effective, and well-tolerated procedure with good sensitivity and has a potential clinic value for the diagnosis of gastrointestinal diseases in minors.
Bone Marrow-Derived Endothelial Progenitor Cells Contribute to Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats via Inhibition of Store-Operated Ca2+ Channels
Authors: Miao Ran , Wan Jun , Liu Jie , Yuan Jason X.-J. , Wang Jing , Xie Wanmu , Zhai Zhenguo , Wang Chen
Published: September 2018

Purpose. This study aimed to explore whether bone marrow- (BM-) derived endothelial progenitor cells (EPCs) contributing to monocrotaline- (MCT-) induced pulmonary arterial hypertension (PAH) in rats via modulating store-operated Ca2+ channels (SOC). Methods. Sprague Dawley (SD) rats were assigned into MCT group (n = 30) and control group (n = 20). Rats in MCT group were subcutaneously administered with 60 mg/kg MCT solution, and rats in control group were injected with equal amount of vehicle. After 3 weeks of treatment, right ventricular systolic pressure (RVSP) and right ventricular hypertrophy index (RVHI) of two groups were measured, and BM-derived EPCs were isolated. Immunochemistry identification and vasculogenesis detection of EPCs were then performed. Ca2+cyt measurement was performed to detect store-operated calcium entry (SOCE) in two groups, followed by determination of Orai and canonical transient receptor potential (TRPC) channels expression. Results. After 3 weeks of treatment, there were significant increases in RVSP and RVHI in MCT group compared with control group, indicating that MCT successfully induced PAH in rats. Moreover, the SOCE (Ca2+cyt rise) in BM-derived EPCs of MCT group was lower than that of control group. Furthermore, the expression levels of Orai3, TRPC1, TRPC3, and TRPC6 in BM-derived EPCs were decreased in MCT group in comparison with control group. Conclusions. The SOC activities were inhibited in BM-derived EPCs of MCT-treated rats. These results may be associated with the depressed expression of Orai3, TRPC1, TRPC3, and TRPC6, which are major mediators of SOC.
A Novel Frequency Scanning Leaky-Wave Antenna Based on Corrugated Substrate Integrated Waveguide
Authors: Chen Ke , Zhang Yunhua , He Siyuan , Chen Haitao , Zhu Guoqiang
Published: September 2018

In order to facilitate the integration of active devices, a leaky-wave antenna (LWA) based on corrugated substrate integrated waveguide (CSIW) structure is proposed. By introducing rectangular ring slots on the CSIW structure, the proposed LWA is capable of beam scanning from backward to forward. The rectangular ring slots do not only enable energy leaking but also provide series capacitance. In addition, the grounded vias and quarter-wave open-circuit stubs provide shunt inductance. Thus, the proposed CSIW exhibits left-handed characteristic which enables beam scanning through the broadside. To further facilitate the design and suppress open-stopband of beam scanning antenna based on CSIW structure, an equivalent circuit model is developed and the relationships between structure parameters and the equivalent circuit parameters are presented. Based on this design guide, a leaky wave antenna is designed with radiation angle ranging from −53° to 23°. This proposed novel CSIW LWA has great potential in tunable or reconfigurable antenna design due to its ease of integration with active devices.
Iterative Rupture of the Patellar Tendon: A Case Report of an Original Technique for Revision Reconstruction Using an Adjustable Loop and an Artificial Ligament
Authors: Bouguennec N. , Colombet P.
Published: September 2018

Chronic rupture of the patellar tendon is a severe injury that leads to dramatic functional consequences including lack of extension and walking difficulty. Surgery is the gold standard to treat this type of injury, but revision reconstructions are problematic because an ipsilateral graft was often harvested for the initial surgery. Because fibrotic tissues on the patellar tendon need to be debrided, another graft must be added to reinforce the tendon. We reported the case of a former semiprofessional handball player, a 29-year-old man who presented an iterative rupture with the fracture of the transverse patellar tunnel 6 months after reconstruction using a semitendinosus graft and suture repair. We performed revision reconstruction surgery using an artificial ligament placed between the extensor mechanism and the tibia for extra-articular reinforcement to maintain extensor mechanism continuity. Two adjustable loops were also used to repair the patellar tendon tear. At 2-year follow-up, the patient was able to resume the practice of handball at a competitive level with good clinical and functional results. This technique can therefore be used as a salvage procedure for chronic iterative rupture of the patellar tendon.
Experimental Study on the Concept of Hollow-Core Photonic Bandgap Fiber Stethoscope
Authors: Abdallah Adel
Published: September 2018

An experiment is proposed to show the feasibility of using hollow-core photonic bandgap fibers (HC-PBF) in the fiber-optic interferometric stethoscopes to generally improve the sensitivity and overcome the problems associated with the electronic stethoscopes. In the experiment, the HC-1550 is used as a measuring arm of an unbalanced Mach-Zehnder interferometer (MZI) and the conventional single-mode optical fiber (SMF) is used as an isolated reference arm. Detection and demodulation of the relative phase shift is performed passively using phase-generated carrier homodyne technique (PGC). The proposed results indicate the significance of using HC-PBFs in the future stethoscopes.
High Rate Performance of Ca-Doped Li4Ti5O12Anode Nanomaterial for the Lithium-Ion Batteries
Authors: Deng Heming , Liang Wei , Nie Dexin , Wang Jian , Gao Xu , Tang Shun , Liu Cui , Cao Yuan-Cheng
Published: September 2018

The spinel Li4Ti5O12(LTO) has been doped by Ca2+via a solid-state reaction route, generating highly crystalline Li3.9Ca0.1Ti5O12powders in order to improve the electrochemical performance as an anode. The structure changes, morphologies, and electrochemical properties of the resultant powders have been characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and cyclic voltammetry (CV), respectively. Crystal structure and composition were analyzed, and results were obtained with various tests of LTO. Electrochemical measurements revealed that Li3.9Ca0.1Ti5O12anodes exhibit better rate capability, better cycling stability, and a higher specific capacity than pure LTO anodes.
Drug Effect of Thulium(III)-Arsenazo III Complex on Herring Sperm DNA
Authors: Li Hongbo , Lei Shutao , Tang Yongqiong , Zou Liyuan , Hu Hongqin , Wang Suqin
Published: September 2018

To assess the potential cytostatic properties of the thulium(III)-arsenazo III complex as a probe of rare earth complex antitumor drugs, the interaction information of the thulium(III)-arsenazo III complex with DNA was obtained by using spectroscopy, viscosity measurements, and voltammetric methods. The thermodynamic functions demonstrated that the binding constants of the thulium(III)-arsenazo III complex with DNA were Kθ298.15K = 4.84 × 106 L·mol−1 and Kθ308.15K = 4.48 × 106 L·mol−1, and the binding process was enthalpy driven. The increase in relative viscosity of DNA with the addition of the thulium(III)-arsenazo III complex and the results from Scatchard and voltammetric methods showed that the interaction mode between the thulium(III)-arsenazo III complex and DNA was groove binding along with weak intercalative binding.
Beneficial Effects of Poplar Buds on Hyperglycemia, Dyslipidemia, Oxidative Stress, and Inflammation in Streptozotocin-Induced Type-2 Diabetes
Authors: Peng Shiqin , Wei Ping , Lu Qun , Liu Rui , Ding Yue , Zhang Jiuliang
Published: September 2018

The effects of propolis on blood glucose regulation and the alleviation of various complications caused by diabetes have been widely studied. The main source of propolis in the northern temperate zone is poplar buds. However, there is limited research on the antidiabetic activity of poplar buds. In order to evaluate the effect of poplar buds on type-2 diabetes, crude extract and 50% fraction of poplar buds were used to feed streptozotocin-induced type-2 diabetic mice. The results showed that 50% fraction could increase insulin sensitivity and reduce insulin resistance, as well as decrease the levels of fasting blood glucose, glycated hemoglobin, and glycosylated serum proteins in diabetic mice. Compared with the model control group, the 50% fraction-treated group showed significant decreases of malondialdehyde (MDA) and increases of superoxide dismutase (SOD) in serum and liver homogenate. Moreover, 50% fraction could significantly decrease total cholesterol (TC), alleviate abnormal lipid metabolism, and enhance antioxidant capacity in the serum. For inflammatory factors, feeding of 50% fraction could also reduce the levels of interleukin 6 (IL-6), tumor necrosis factorα(TNF-α), monocyte chemotactic protein 1 (MCP-1), and cyclooxygenase-2 (COX-2) in liver homogenate. Taken together, our results suggest that crude extract and 50% fraction of poplar buds, particularly the latter, can decrease blood glucose levels and insulin resistance, and 50% fraction can significantly relieve dyslipidemia, oxidative stress, and inflammation caused by type-2 diabetes.
Trends in Route of Hysterectomy after the Implementation of a Comprehensive Robotic Training Program
Authors: Papalekas Eleni , Fisher Jay
Published: September 2018

Objective. To evaluate trends in surgical approach for hysterectomy following the introduction and implementation of a comprehensive robotic surgery program. Methods. A retrospective review of all hysterectomies done at two institutions, a community hospital and a suburban, tertiary-care teaching hospital, in the same health system over a five-year period, January 2010 through December 2014. A robotic surgery training program was implemented during the first year of the study and trends in route of hysterectomy were evaluated in the subsequent years. Results. A total of 5175 patients undergoing hysterectomy, for both benign and malignant indications, were included in the study. There was a significant decrease in the percent of cases performed through an abdominal approach at both the community and teaching hospitals (19.3% decline at each institution). There was an inversely related significant increase in the percent of robotic procedures at both the community and teaching hospitals (44.5% and 17%, respectively). A decrease in number of cases performed vaginally over this period was only noted in the community hospital site (25.2% decrease), and there was a slightly higher rate of vaginal hysterectomies at the teaching hospital over this study period (21.9% in 2010, 24.1% in 2014). Conclusion. The decrease in number of abdominal and laparoscopic hysterectomies and increase in number of robotic hysterectomies that was seen are consistent with national trends. The initiation of a robotic training program did not prevent the proliferation of use of the robot but did aim to ensure proficiency on the robot prior to gaining privileges for patient use. This type of comprehensive training and monitoring program could be applied to future technologic advances to ensure a standard level of surgical proficiency. Trends in route of hysterectomy are clearly multifactorial and involve patient, provider, and location-specific factors that are likely to continue to change.
Heart Rate Variability and Cardiovascular Reflex Tests for Assessment of Autonomic Functions in Preeclampsia
Authors: Chaswal Meenakshi , Kapoor Raj , Batra Achla , Verma Savita , Yadav Bhupendra S.
Published: September 2018

Alterations in the autonomic cardiovascular control have been implicated to play an important etiologic role in preeclampsia. The present study was designed to evaluate autonomic functions in preeclamptic pregnant women and compare the values with normotensive pregnant and healthy nonpregnant controls. Assessment of autonomic functions was done by cardiovascular reflex tests and by analysis of heart rate variability (HRV). Cardiovascular reflex tests included deep breathing test (DBT) and lying to standing test (LST). HRV was analyzed in both time and frequency domain for quantifying the tone of autonomic nervous system to the heart. The time domain measures included standard deviation of normal R-R intervals (SDNN) and square root of mean squared differences of successive R-R intervals (RMSSD). In the frequency domain we measured total power (TP), high frequency (HF) power, low frequency (LF) power, and LF/HF ratio. Cardiovascular reflex tests showed a significant parasympathetic deficit in preeclamptic women. Among parameters of HRV, preeclamptic group had lower values of SDNN, RMSSD, TP, HF, and LF (ms2) and higher value of LF in normalised units along with high LF/HF ratio compared to normotensive pregnant and nonpregnant controls. Furthermore, normotensive pregnant women had lower values of SDNN, TP, and LF component in both absolute power and normalised units compared to nonpregnant females. The results confirm that normal pregnancy is associated with autonomic disturbances which get exaggerated in the state of preeclampsia.
Effects of Oral Supplementation with Docosahexaenoic Acid (DHA) plus Antioxidants in Pseudoexfoliative Glaucoma: A 6-Month Open-Label Randomized Trial
Authors: Romeo Villadóniga Stéphanie , Rodríguez García Elena , Sagastagoia Epelde Olatz , Álvarez Díaz M. Dolores , Domingo Pedrol Joan Carles
Published: September 2018

Purpose. To assess the effects of antioxidant oral supplementation based on docosahexaenoic acid (DHA) in pseudoexfoliative (PEX) glaucoma. Patients and Methods. A prospective 6-month open-label randomized controlled trial was conducted in patients with PEX glaucoma and adequate intraocular pressure (IOP) control. Patients in the DHA group received a high-rich DHA (1 g) nutraceutical formulation. Ophthalmological examination, DHA erythrocyte membrane content (% total fatty acids), plasma total antioxidant capacity (TAC), plasma malondialdehyde (MDA), and plasma IL-6 levels were assessed. Results. Forty-seven patients (DHA group 23, controls 24; mean age 70.3 years) were included. In the DHA group, the mean IOP in the right eye decreased from 14.7 [3.3] mmHg at baseline to 12.1 [1.5] mmHg at 6 months (P=0.01). In the left eye, IOP decreased from 15.1 [3.3] mmHg at baseline to 12.2 [2.4] mmHg at 6 months (P=0.007). DHA erythrocyte content increased in the DHA group, with significant differences versus controls at 3 months and 6 months (8.1% [0.9] vs. 4.4% [0.7]; P<0.0001). At 6 months and in the DHA group only, TAC levels as compared with baseline increased significantly (919.7 [117.9] vs. 856.9 [180.3] µM copper-reducing equivalents; P=0.01), and both MDA (4.4 [0.8] vs. 5.2 [1.1] nmol/mL; P  =  0.02) and IL-6 (2.8 [1.3] vs. 4.7 [2.3] pg/mL; P=0.006) levels were lower than in controls. Conclusions. Targeting pathophysiology mechanisms of PEX glaucoma by reducing oxidative stress and inflammation with a high-rich DHA supplement might be an attractive therapeutic approach. Despite the short duration of treatment, decrease in IOP supports the clinical significance of DHA supplementation.
An Efficient Teager Energy Operator-Based Automated QRS Complex Detection
Authors: Beyramienanlou Hamed , Lotfivand Nasser
Published: September 2018

Database. The efficiency and robustness of the proposed method has been tested on Fantasia Database (FTD), MIT-BIH Arrhythmia Database (MIT-AD), and MIT-BIH Normal Sinus Rhythm Database (MIT-NSD). Aim. Because of the importance of QRS complex in the diagnosis of cardiovascular diseases, improvement in accuracy of its measurement has been set as a target. The present study provides an algorithm for automatic detection of QRS complex on the ECG signal, with the benefit of energy and reduced impact of noise on the ECG signal. Method. The method is basically based on the Teager energy operator (TEO), which facilitates the detection of the baseline threshold and extracts QRS complex from the ECG signal. Results. The testing of the undertaken method on the Fanatasia Database showed the following results: sensitivity (Se) = 99.971%, positive prediction (P+) = 99.973%, detection error rate (DER) = 0.056%, and accuracy (Acc) = 99.944%. On MIT-AD involvement, Se = 99.74%, P+ = 99.97%, DER = 0.291%, and Acc = 99.71%. On MIT-NSD involvement, Se = 99.878%, P+ = 99.989%, DER = 0.134%, and Acc = 99.867%. Conclusion. Despite the closeness of the recorded peaks which inflicts a constraint in detection of the two consecutive QRS complexes, the proposed method, by applying 4 simple and quick steps, has effectively and reliably detected the QRS complexes which make it suitable for practical purposes and applications.
Optimal Use of Ganciclovir and Valganciclovir in Transplanted Patients: How Does It Relate to the Outcome?
Authors: Mozaffar Maryam , Shahidi Shahrzad , Mansourian Marjan , Badri Shirinsadat
Published: September 2018

Objective. Organ transplant recipients receive immunosuppressive regimens to prevent transplant rejection, which put them at increased risk for opportunistic infections like cytomegalovirus (CMV). Ganciclovir and Valganciclovir are mostly used to prevent or treat CMV. Any incorrect use of the drug may have serious consequences for patients. In this study, the outcome of transplant recipients was assessed in relation to the optimal or suboptimal use of Ganciclovir or Valganciclovir.Methods. This study was performed on 148 hospitalized patients who received Ganciclovir or Valganciclovir in the nephrology and kidney transplantation departments of our university hospitals, from March 2012 to December 2016. Patients’ demographic and clinical data including dose and duration of treatment were collected and then analyzed in comparison with the standard CMV treatment protocols.Findings. About 94.6% of patients received Ganciclovir or Valganciclovir therapy consistent with the standard defined indications. The mean ratio of prescribed daily dose to the optimal dose was 2.9 in the first dose, 2.0 in the second dose, 1.3 in the third dose, and 1.5 in the fourth dose. From 148 included patients, 26.5% experienced CMV infection once, 7.2% experienced CMV infection twice, and 1.2% had CMV infection for 3 times, within six-month follow-up after first episode of antiviral therapy during hospitalization.Conclusion. In this study, empiric anti-CMV therapy was initially given. The doses used were generally higher than recommended but we could not find more adverse events in the patients receiving high initial doses. In any case, it seems necessary to advocate use of standard treatment guidelines to avoid adverse outcomes.
A Chinese Traditional Therapy for Bleomycin-Induced Pulmonary Fibrosis in Mice
Authors: Sun Lifang , Mao Minjie , Yan Zhisheng , Zuo Cuiyun , Zhang Xiaojie
Published: September 2018

Pulmonary fibrosis is a chronic and fatal disease of lung tissue with high incidence and mortality in the world. The exploration of effective treatment for pulmonary fibrosis remains an urgent challenge. In our study, Qingfei Xieding was investigated as a novel Chinese traditional patent medicine against pulmonary fibrosis. A pulmonary fibrosis mouse model was constructed by injecting with bleomycin sulfate. Following Qingfei Xieding administration, lung samples were collected to assess pulmonary phenotype changes by analyzing lung coefficient, wet/dry, and histopathologic section. Levels of nitric oxide (NO), hydroxyproline (HYP), malondialdehyde (MDA), and total antioxidant capacity were measured to evaluate the degree of oxidation. A single-cell gel electrophoresis (SCGE) assay was used to evaluate bleomycin-induced DNA damage. Western blotting and real-time quantitative PCR were performed to determine the abundance of inducible nitric oxide synthase (iNOS), connective tissue growth factor (CTGF), alpha smooth muscle actin (α-SMA), and fibronectin (FN). In the present study, Qingfei Xieding administration significantly attenuated bleomycin-induced pulmonary fibrosis in mice by reducing lung coefficient, wet/dry, NO, HYP, and MDA as well as the expression of iNOS, CTGF, α-SMA, FN, and DNA damage. The results indicated that Qingfei Xieding is effective to resist oxidative damage and histopathologic lesion, serving a protection role on bleomycin-induced pulmonary fibrosis.
Benefit of Contact Force Sensing Catheter Technology for Successful Left Atrial Anterior Line Formation: A Prospective Randomized Trial
Authors: Fichtner Stephanie , Wakili Reza , Rizas Konstantinos , Siebermair Johannes , Sinner Moritz F. , Wiktor Thomas , Lackermair Korbinian , Schuessler Franziska , Olesch Lucia , Rainer Susanne , Kääb Stefan , Curta Adrian , Kramer Harald , Estner Heidi L.
Published: September 2018

Introduction. The value of contact force information for ablation of LA anterior line is unknown. In a prospective randomized clinical trial, we investigated if information on contact force during left atrial (LA) anterior line ablation reduces total radiofrequency time and results in higher rates of bidirectional line block in patients undergoing pulmonary vein isolation (PVI) plus substrate modification. Methods. We included patients with indication for pulmonary vein isolation (PVI) and additional substrate modification. For LA anterior line ablation, patients were randomized to contact force information visible (n=35) or blinded (n=37). Patients received contrast enhanced cardiac magnetic resonance imaging (cMRI) before and 3-6 months after ablation to visualize the LA anterior line. Primary endpoint was radiofrequency time to achieve bidirectional line block. Secondary endpoints were completeness of the LA anterior line on cMRI, distribution of contact force, procedural data, adverse events, and 12 months success rate. Results. In 72 patients (64±9 years, 68% male), bidirectional LA anterior line block was achieved in 70 (97%) patients. Radiofrequency time to bidirectional block did not differ significantly across groups (contact force information visible 23±18min versus contact force information blinded 21±15min, p=0.50). The LA anterior line was discernable on cMRI in 40 patients (82%) without significant differences across randomization groups (p=0.46). No difference in applied contact force was found depending on cMRI line visibility. Twelve-month success and adverse event rates were comparable across groups. Conclusion. Information on contact force does not significantly improve the ablation of LA anterior lines. Clinical Trial Registration. The trial was registered at http://www.clinicaltrials.gov by identifier: NCT02217657.
Comprehensive Phenotypic Characterization of Human Invasive Lobular Carcinoma Cell Lines in 2D and 3D Cultures
Authors: Tasdemir Nilgun , Bossart Emily A. , Li Zheqi , Zhu Li , Sikora Matthew J. , Levine Kevin M. , Jacobsen Britta M. , Tseng George C. , Davidson Nancy E. , Oesterreich Steffi
Published: September 2018

Invasive lobular carcinoma (ILC) is the second most common subtype of breast cancer following invasive ductal carcinoma (IDC) and characterized by the loss of E-cadherin–mediated adherens junctions. Despite displaying unique histologic and clinical features, ILC still remains a chronically understudied disease, with limited knowledge gleaned from available laboratory research models. Here we report a comprehensive 2D and 3D phenotypic characterization of four estrogen receptor–positive human ILC cell lines: MDA-MB-134, SUM44, MDA-MB-330, and BCK4. Compared with the IDC cell lines MCF7, T47D, and MDA-MB-231, ultra-low attachment culture conditions revealed remarkable anchorage independence unique to ILC cells, a feature not evident in soft-agar gels. Three-dimensional Collagen I and Matrigel culture indicated a generally loose morphology for ILC cell lines, which exhibited differing preferences for adhesion to extracellular matrix proteins in 2D. Furthermore, ILC cells were limited in their ability to migrate and invade in wound-scratch and transwell assays, with the exception of haptotaxis to Collagen I. Transcriptional comparison of these cell lines confirmed the decreased cell proliferation and E-cadherin–mediated intercellular junctions in ILC while uncovering the induction of novel pathways related to cyclic nucleotide phosphodiesterase activity, ion channels, drug metabolism, and alternative cell adhesion molecules such as N-cadherin, some of which were differentially regulated in ILC versus IDC tumors. Altogether, these studies provide an invaluable resource for the breast cancer research community and facilitate further functional discoveries toward understanding ILC, identifying novel drug targets, and ultimately improving the outcome of patients with ILC.

Significance: These findings provide the breast cancer research community with a comprehensive assessment of human invasive lobular carcinoma (ILC) cell line signaling and behavior in various culture conditions, aiding future endeavors to develop therapies and to ultimately improve survival in patients with ILC. Cancer Res; 78(21); 6209–22. ©2018 AACR.