bluuebunny/crossref_metadata_2025 huggingface dataset:
Mobile Gas Leakage Detection System
Authors: R Anagha , Rao Abhishek
Published: July 2022

Abstract: The most prominent industrial disasters are caused due to gas leakage. One of the preventive methods to stop accident associated with the gas leakage is to install mobile gas leakage detection system at vulnerable places. The aim of this paper is to present such a design that can automatically detect the gas leakage and send alerts to the nearby workers in vulnerable premises. Gas sensor has been used which has high sensitivity for propane (C3H8) and butane (C4H10). Gas leakage system consists of Arduino microcontroller with inbuilt Wi-fi module (ESP8266), ultrasonic sensor for crack detection, MQ2 sensor for gas leakage detection and Blynk app to receive the alerts. This paper provides the design approach on both software and hardware
Block Chain Based Information Storage with Concealment and Authentication in Internet of Things
Authors: Thrishu E.
Published: July 2022

Abstract: In both academics and industry, the Internet of Things (IOT) is driving a digital revolution. It makes people's life easier, but it also raises concerns about security and privacy. Blockchain, a decentralised database based on cryptographic principles, has the potential to impact a wide range of industries, including manufacturing, banking, and commerce. Though researchers offer a variety of security and data storage solutions, only a few are suitable for WSN- enabled IoTs. As a result, a blockchain- based decentralised framework with authentication and concealment- preserving techniques has been established for secure communication in WSN-enabled IoTs. Cluster heads send the collected data to the Base Station (BS) in this scheme. As a result, BS keeps track of all the key parameters on the distributed blockchain, which is quite extensive.
User Behavior Prediction of Social Hotspots Using Interaction with Multiple Messages and Neural Networks
Authors: Bharathi Mrs. N.
Published: July 2022

Abstract: The variety of communications under social hot topics has a significant impact on user engagement behaviour in network public opinion study. This article suggests a prediction model of user participation behaviour during repeated messaging of trending social issues, taking into account interactions between numerous messages and complicated user behaviours. A multimessage interaction influence-driving method was first presented to better precisely forecast user involvement behaviour by taking into account the impact of multimessage interaction on user participation behaviour. Second, this study proposes a user participant behaviour prediction model of social hotspots based on a multimessage interaction-driving mechanism and the BP neural network. This is done in light of the behavioural complexity of users participating in multimessage hotspots and the simple structure of backpropagation (BP) neural networks (which can map complex nonlinear relationships).
A New Technique for Wireless Sensor Network Intrusion Prevention Using Dense Artificial Neural Networks
Authors: Shrivastava Saurabh
Published: July 2022

Abstract: A wide range of industries, including security, healthcare, and industrial settings, currently employ wireless sensor networks (WSNs). With a limited power supply, bandwidth, and energy consumption, WSNs are unique. While traditional networks can be protected in many ways, WSNs cannot be protected in the same way. In order to enhance the service safety of wireless sensor networks, new concepts as well as methodologies were needed. In WSNs, intrusion prevention is the most important issue. For WSN Intrusion Detection (IDS), this research used Dense Artificial Neural Networks (DANN) to develop a DL technique (DeepANN). Compared to the previous models, the proposed Analytical model achieved a 95 percent accuracy rate. The ANN model outperforms the other ML models, with F1 scores of 99, 98, and 96.
DoSMit: A Novel Way for the Mitigation of Denial of Service Attacks in Software Defined Networking
Authors: N G Sreejesh
Published: July 2022

Abstract: Software Defined Networking (SDN) is a rapidly evolving technology in the field of networking. It allows the computer networks to be managed via software instead of hardware devices. It gives the benefit of simplicity in management and easiness to apply new features in the network. Thus scalability, performance and maintainability become more sophisticated compared to the legacy hardware driven networks. But the SDN has more chances of being attacked by hackers, thus compromising the entire network. One common such threat is Denial of Service (DoS). Apart from such attacks in the legacy networks, the DoS attacks can be aimed at the SDN controller, Openflow switch and the controller-switch link by exhausting their resources. This paper proposes a novel and simple method to detect and mitigate such attacks through a Heavy Packet-in Flow Mitigation feature. Also it introduces an add-on feature ARP Flood Rule to reduce the number of ARP packets during the network initial boot up time. With both the features enabled, the network can reduce the packet-in flows to the controller and rescue the controller from overwhelming with huge packet-in message processing.
Review on Effect of Anti-Stripping Agent and Cement on Indirect Tensile Strength of Bituminous Concrete
Authors: . Vishwakarma Vinod Kr
Published: July 2022

Abstract: Pavement engineers much concerned about the tensile properties of bituminous mix because of the problems associated with cracking. Hence tensile strength of bituminous concrete mix is important in pavement applications. The Indirect Tensile Strength (ITS) test is used to assess the tensile properties of the bituminous mix. Addition of cement or lime is known to impart Anti-Stripping properties to bituminous mixes. For adverse conditions however use of Anti-Stripping chemicals is desired. It is important to ensure that addition of such compound may not have adverse effect on other properties. Many researches were done on ITS individually; however, a combination has not been tried yet. In this proposal, an effort has been made to study the techniques of addition of Anti-Stripping and Cement material both individually and combined in suitable proportions on bituminous concrete.
Programmable DC-DC Buck Converter
Authors: Verma Vipin
Published: July 2022

Abstract: Design of the power electronics circuitry are now-a-days reducing the size, space and weight of converter and inverter circuits. This is possible because of the availability of new high switching frequency devices. This paper presents a generalized model of buck converters that is programmable. The converter used for stepping down the voltage is called buck converter. Buck converter is designed, analysed, simulated & developed. The proposed model of this Buck converter consists of two parts: (a) Main converter circuits with the components like switch, inductor, diode, capacitor, and a load, (b) A control circuit for controlling the operation of the switch using microcontroller through digital potentiometer. This model can accurately give the power output voltage up-to three decimals.
Driver Drowsiness Detection Using OpenCV and Raspberry Pi
Authors: D.C Pooja
Published: July 2022

Abstract: A countless number of people drive on the highway day and night. People traveling long-distance suffer from lack of sleep. Due to which it becomes very dangerous to drive when feeling sleepy. The majority of accidents happen due to the drowsiness of the driver. According to a thorough investigation, there are over 500,000 accidents in India alone each year. Furthermore, driver fatigue is a factor in almost 60 percent of these accidents. In this paper, we provide a real-time monitoring system that makes use of face / eye identification and image processing algorithm. Driver drowsiness detection is a vehicle safety technology which prevents accidents when the driver is getting drowsy.
Обобщенные модели долговечности и их применение для решения задач прогнозирования определяющих характеристик композитов
Authors:   Институт проблем нефти и газа ФИЦ “Якутский научный центр Сибирского отделения РАН”, Гусев Е. Л , Бакулин В. Н. ,   Институт математики и информатики Северо-Восточного Федерального университета,   Институт прикладной механики РАН,   Московский авиационный институт (Национальный исследовательский университет)
Published: July 2022

Работа посвящена актуальной проблеме прогнозирования долговечности полимерных композитов при воздействии экстремальных факторов внешней среды и эксплуатационных нагрузок. Оценивали возможности эффективного прогнозирования определяющих характеристик (остаточного ресурса, прочности, надежности, долговечности) на основе информации, полученной в первые годы эксплуатации. В основу разработки обобщенных моделей долговечности композитов в экстремальных условиях положены базовые положения современной молекулярно-кинетической теории (МКТ), учитывающей возможности химических превращений в композитах как на межмолекулярном, так и на внутримолекулярном уровне. На основе современных положений МКТ исследован вопрос о согласовании определяющих параметров математических моделей, учитывающих результаты экспериментальных измерений на макроуровне, с соответствующими определяющими параметрами физических моделей, описывающих молекулярные взаимодействия на микроуровне. Приведены результаты вычислительных экспериментов.
Механика деформирования тест-образцов из слоистых волокнистых композитов со структурой [±45°] при испытаниях на растяжение и сжатие. 1. Теоретико-экспериментальные методы определения механических характеристик и параметров напряженно-деформированного состояния
Authors:   Казанский национальный исследовательский технический университет им. А. Н. Туполева, Паймушин В. Н. , Газизуллин Р. К. , Холмогоров С. А. , Шишов М. А. ,   Казанский (Приволжский) федеральный университет
Published: July 2022

Проведен анализ теоретико-экспериментальных методов определения механических характеристик слоистых волокнистых композитных материалов (ВКМ) при испытаниях на растяжение и сжатие плоских тест-образцов со структурами [0°]s, [90°]s, [±45°]2s. Для ВКМ со структурой [±45°]2s выведены соотношения для нахождения деформаций и напряжений в осях ортотропии материала отдельного монослоя ВКМ через замеряемые в эксперименте осевую деформацию и коэффициент Пуассона образца. Они основаны на построении соотношений, исходя из рассмотрения геометрической картины деформирования и анализа известных кинематических и физических соотношений теории упругости, составленных для каждого монослоя композита в предположении о формировании в нем плоского напряженнодеформированного состояния. Проведены упрощения последних в предположении о том, что в косоугольно армированном ВКМ два смежных слоя со структурами [±  ] допустимо считать как один симметрично армированный слой с ортотропными свойствами. В линейной постановке двух- и трехмерных задач в программной системе конечно-элементного анализа ANSYS проведены численные эксперименты по определению параметров напряженно-деформированного состояния образцов, состоящих из двух и четырех жестких монослоев однонаправленного волокнистого композитного материала со структурой [±45°]2s, путем введения в рассмотрение между смежными жесткими слоями менее жестких адгезионных слоев малой толщины, состоящих только из материала связующего. Рассмотрены случаи растяжения удлиненных и сжатия коротких тест-образцов, проведен анализ формирующихся компонент напряжений вдоль волокон, расположенных в центральной части и в окрестностях угловых точек образцов. Проведены эксперименты на растяжение плоских тест-образцов из волокнистого композита со схемой укладки [±45°]2s по определению деформированного состояния с использованием системы бесконтактного измерения деформаций. Полученные результаты позволяют указать области, в которых в процессе нагружения происходит локализация деформаций и начинается разрушение тест-образцов. Показано, что в случае растяжения (сжатия) тест-образцов со структурой [±45°]2s волокна в композите находятся под действием не только касательных, но и осевых растягивающих (сжимающих) напряжений. Установлено, что в осях ортотропии каждого монослоя осевые растягивающие напряжения по величине значительно превосходят поперечные, которыми можно пренебречь.
Анализ свободных колебаний слоистых микропластин с пластинками графена и пьезоэлектрическими лицевыми слоями, покоящихся на упругом основании и подверженных термоэлектрическим нагрузкам
Authors:   Faculty of Engineering, Shahrekord University, Аббаспур Ф. , Арвин Х.
Published: July 2022

Выполнен анализ свободных колебаний микропластин, армированных пластинками графена, опирающихся на упругое основание и подверженных электрическому напряжению в условиях термической окружающей среды. Для вычисления их кинетической энергии и энергии деформирования использовали теорию сдвигового деформирования первого порядка и модифицированную теорию моментных напряжений. Термомеханические характеристики слоя сердцевины, армированного пластинками графена, определены с помощью микромеханической модели Халпина—Цая. Для нахождения соответствующих собственных частот при разных граничных условиях использовали метод Ритца. Исследовано влияние геометрии пластинок графена, их массового содержания, приращения температуры, электрического напряжения и граничных условий на характеристики свободных колебаний. Полученные результаты показали, что декремент основной собственной частоты микропластин зависит от приращения температуры.
Improvement of sentencing Guidelines
Authors:   Wonkwang University Legal Research Institute has, Kim Hye Kyung
Published: July 2022

Since the establishment and application of the sentencing guidelines for murder crimes began in 2009, a total of 44 sentencing standards for crime types have been established or revised by the 8th Sentencing Committee over the past 13 years. And more than 90% of cases that are already subject to trial have sentencing standards. Now, it is necessary to explore the direction of the sentencing committee in the future and pursue righteous punishment and fair sentencing.
Here is aimed to review some issues that need to be improved regarding the 'reasonable sentencing guideline' necessary to form a fair future of justice. First of all, based on the contents of the analysis of the application status of the sentencing guidelines, it is intended to analyze how the sentencing factors are actually affecting the application of the sentencing guidelines. Next will discuss whether the sentencing criteria should bind the court's judgment. This is because if the sentencing guideline does not bind the court, and it becomes a judicial practice to deviate from the sentencing guideline, it may not be necessary to establish the sentencing guidelines. In addition, the meaning of judges complying with the sentencing guidelines can be a criterion for evaluating the public's trust in judicial law.
In addition, it is necessary to verify the validity of the grounds for considering probation. Until now, among the special sentencing factors, the mitigation factor has been recognized as a positive factor for probation, and the aggravated factor has been cross-applied as a negative factor. However, it is necessary to determine whether such cross-application is reasonable. This is also a matter of connection between the two. In addition, the possibility of establishing the selection criteria for imprisonment and fines should be studied. The criminal law selectively stipulates imprisonment and fines for most crimes. Therefore, it will be necessary to objectively ensure the predictability of what punishment criminals will be imposed.
Finally, we will look at the problem of harmony with the day fines system. This is because it is difficult to harmonize with the day fines system that converts the amount of illegality into days if the upper and lower limits of fines are set while creating the penalty standard for fines.
Through these studies, it is necessary to establish righteous punishment and fair sentencing, and to ensure the people's judicial trust through those.
Cytomorphological and biochemical implications of UV-B priming in fennel (Foeniculum vulgare Mill.)
Authors:   Plant Genetics Laboratory, Department of Botany, University of Allahabad, Prayagraj-211 002, India, Mishra M. , Kumar G. ,   Plant Genetics Laboratory, Department of Botany, University of Allahabad, Prayagraj-211 002, India, Tripathi K. ,   Plant Genetics Laboratory, Department of Botany, University of Allahabad, Prayagraj-211 002, India
Published: July 2022

Aim: The aim of this study was to create variability on the morphogenetic make- up, and biochemical attributes of fennel plant which incurred as a result of different exposure of UV-B radiation. Methodology: Seedlings of Foeniculum vulgare Mill. were treated with four different exposure times viz. Set A for Control, Set B for 20 min, Set C for 40 min, Set D for 60 min and Set E for 80 min, respectively. UV-B exposure seedlings with respect to control were transplanted to their respective pots and fields. Three replicates were prepared for each treatment. During the course of growth and development, few morphological, biochemical, and cytological parameters were estimated. Results: The results clearly elucidate that the higher exposure to UV-B radiation substantially affected the growth parameters whereas UV-B radiation (40 min) induced certain beneficial traits viz., increased plant height, intermodal length, etc. Various types of chromosomal aberrations such as stickiness, scattering, precocious, laggard, etc., were also observed. Scattering was the main chromosomal abnormality encountered at longer durations (60-80 min) to UV-B exposure. It was also observed that withincrease in the duration of UV-B exposure (20-80 min), there was a decrease in chlorophyll a (0.98 to 0.82) and chlorophyll b (0.68), and increase in carotenoids (at lower duration of UV-B radiation) was also observed. A maximum increment in carotenoid content was recorded in 40 min treated sets. Interpretation: The present research would be helpful in selecting doses which impart characters of interest in Foeniculum vulgare Mill. The cytological alterations caused by UV-B radiation changes the genetic makeup of fennel, which can be inherited to the subsequent generation to create agronomical superior mutants which will be promising materials for plant breeders in near future.
Water using source of a perennial semi-shrub Reaumuria soongorica as measured by water isotopes in Gobi Desert, Inner Mongolia, China
Authors:   College of Desert Control Science and Engineering, Inner Mongolia Agricultural University. 306 Zhaowuda Road, Saihan District,  Hohhot, Inner Mongolia, People’s Republic of China-010 010, Liu R.X. , Ma Y.M. ,   College of Desert Control Science and Engineering, Inner Mongolia Agricultural University. 306 Zhaowuda Road, Saihan District,  Hohhot, Inner Mongolia, People’s Republic of China-010 010, Liu B. ,   College of Desert Control Science and Engineering, Inner Mongolia Agricultural University. 306 Zhaowuda Road, Saihan District,  Hohhot, Inner Mongolia, People’s Republic of China-010 010, Chen S.C. ,   College of Desert Control Science and Engineering, Inner Mongolia Agricultural University. 306 Zhaowuda Road, Saihan District,  Hohhot, Inner Mongolia, People’s Republic of China-010 010, Hu H.F. ,   Institute of Grassland Research, Chinese Academy of Agricultural Sciences, 120 East Wulanchabu Road, Saihan District,  Hohhot, Inner Mongolia, 010018, People’s Republic of China, Mi Y.J. ,   College of Desert Control Science and Engineering, Inner Mongolia Agricultural University. 306 Zhaowuda Road, Saihan District,  Hohhot, Inner Mongolia, People’s Republic of China-010 010
Published: July 2022

Aim: Reaumuria soongorica plays significant role in wind induced soil erosion and combating desertification due to its unique adaptation mechanisms in the Gobi Desert. This study was conducted to investigate its water using sources revealed by hydrogen and oxygen stable isotope as one of its adaptive strategies in Gobi Desert. Methodology: Field experiment was designed in Alashan Desert, China to evaluate the soil and plant water conditions from two R. soongorica sampling sites. Plant and soil water potential were measured by using the Psypro dew point water potential meter equipped with C-52 sample chamber. Water isotopes was measured based on hydrogen (Δ2H) and oxygen (δ18O) stable isotopes. Results: The results showed that the highest soil moisture content in both sites at 70~100 cm was 2.08% and 1.28%, respectively. The average leaf water content of R. soongorica ranged from 18.032% to 38.063% and the average water potential of its root, stem, and leaf was -8.89 and -9.71 MPa for site I and II, respectively. Δ2H and δ18O stable isotope analysis showed that soil water source for R. soongorica for both sites was from layer of 70~100 cm. Interpretation: R. soongorica uses water mainly from the medium soil layer and the results uncover its water using strategies as one of adaptive mechanism in Gobi Desert.
INTEGRAÇÃO A CONTEXTOS DE L2 DOMINANTES E ADAPTABILIDADE FONOLÓGICA DE L1: UMA ANÁLISE DA PRODUÇÃO DAS PLOSIVAS SURDAS DO PORTUGUÊS BRASILEIRO
Authors: Kupske Felipe Flores , Lima Jr Ronaldo Mangueira
Published: July 2022

Adotando a Teoria dos Sistemas Dinâmicos Complexos, este trabalho investiga o relacionamento entre padrões de integração à língua e ao país hospedeiro e a adaptabilidade fonológica de L1. Uma análise da produção do VOT do PB, originalmente curto (short lag), por imigrantes brasileiros de primeira geração no Reino Unido (N = 24), contexto de inglês dominante, língua de VOT longo (long lag) foi conduzida. A análise acústica, medição de VOT em milissegundos, é reportada. Para análise estatística inferencial, foram ajustados três modelos bayesianos de regressão linear com efeitos mistos. Os modelos preveem, com alta credibilidade, aumentos na duração de VOT do PB ao passar do tempo, sendo que um aumento maior é previsto para o grupo de falantes afiliados ao contexto de L2 dominante. Os dados apontam que há consistência lógica para a hipótese de que a fonologia é impulsionada/afetada pelo uso e, consequentemente, é sensível ao contexto/ambiente.
Robo-advisors as part of industry 4.0 in financial markets: Evolutionary development, methods, and first performance insights
Authors: Holtfort Thomas , Horsch Andreas , Schwarz Joachim
Published: July 2022

Today, an essential disruptive trend of the fourth industrial revolution is robo-advisors that offer innovative asset management services (Tao, Su, Xiao, Dai, & Khalid, 2021). They are automated investment platforms that use quantitative algorithms to produce advice to investors to help them manage their portfolios and are accessible to clients online (Beketov, Lehmann, & Wittke, 2018). Until now, there has been no comprehensive analysis of the development of these innovative advisors, the asset allocation methods used, and the performance (also concerning the Corona crisis). Thus, the paper takes robo-advisory-related research a step further by analyzing the development of robo-advisory on a global scale from an evolutionary point of view, at the same time focusing on the variety of methods applied by the advisors and the factors influencing their performance between 2018 and 2021 by regression analysis. Our results show that modern portfolio theory remains the primary framework used by robo-advisors, even though some use new approaches. The average performance of robo-advisors appears to beat the market benchmark, however not significantly during the Corona-crash period. Important factors influencing their performance are the number of allocation methods applied and, specifically, the technique of rebalancing. The findings demonstrate that in the context of Industry 4.0, robo-advisors can offer advantages not only in terms of costs and technical processes but also in terms of performance.
A monoterpene synthase regulates geraniol formation and plant defense via alternative splicing in tea plants
Authors: Jiang Hao , Zhang Mengting , Yu Feng , Li Xuehui , Jin Jieyang , Zhou Youjia , Wang Qiang , Jing Tingting , Wu Yi , Wan Xiao-Chun , Schwab Wilfried , Song Chuankui
Published: July 2022

Geraniol is an important contributor to the pleasant floral scent of tea
products and one of the most abundant aroma compounds in tea plants;
however, its biosynthesis and physiological function in response to
stress in tea plants remain unclear. Here, we studied eight terpene
synthases with expression levels that were correlated with geraniol
accumulation in different tissues of tea plants. The proteins encoded by
the full-length terpene synthase ( CsTPS1) and its alternative
splicing isoform ( CsTPS1- AS) could catalyze the
formation of geraniol when GPP was used as a substrate in vitro,
whereas the expression of CsTPS1- AS was only
significantly induced by Colletotrichum gloeosporioides and
Neopestalotiopsis sp. infection. Silencing of CsTPS1 and
CsTPS1- AS resulted in a significant decrease in the
geraniol content in tea plants. The geraniol content and antifungal
activity of tea plants were compared when CsTPS1 and
CsTPS1- AS were silenced. Down-regulation of the
expression of CsTPS1- AS reduced the accumulation of
geraniol, and the silenced tea plants exhibited greater susceptibility
to pathogen infection than control plants. However, the geraniol content
and pathogen resistance of CsTPS1-silenced plants and control
plants did not significantly differ. Further analysis showed that
silencing of CsTPS1- AS led to a decrease in the
expression of the defense-related genes PR1 and PR2 and
the expression of SA pathway-related genes in tea plants, which
increased the susceptibility of tea plants to pathogenic fungal
infections . Both in vitro and in vivo results
indicated that CsTPS1 is involved in the regulation of geraniol
formation and plant defense via alternative splicing in tea plants. The
results of this study provide new insights into geraniol biosynthesis
and highlight the role of monoterpene synthases in modulating plant
disease resistance via alternative splicing.
BUCCAL KAPOSI’S SARCOMA ASSOCIATED WITH HIV INFECTION AND COVID-19: A case report
Authors: Ndrianarivony Simon Carnot , Randriamanantena Tahiriarivelo , Harimbonona Zo
Published: July 2022

Kaposi’s sarcoma is a common cancer associated with HIV infection. Since
the COVID-19 pandemic, the prevalence of this pathology has increased.
We report a case of a 33-year-old patient who presented with Kaposi’s
sarcoma associated with Covid-19 and HIV coinfection. It promotes the
progression of cancers and increases mortality.
Analytical and Numerical Study of a Nonlinear Volterra Integro-differential Equation with the Caputo-Fabrizio Fractional Derivative
Authors: Bekkouche Mohamed Moumen , Ahmed Abdelaziz Azeb , Djeradi Fatima , Ziadi Raouf , yazid Fares
Published: July 2022

In this paper we interest concerns an integro-differential equation of
Volterra when the derivative of the solution appears under the sign of
integration in a non-linear way. The derivation is the Caputo-Fabrizio
Fractional Derivative (CF-FD), which increases the interest of this
study. we built Lipchitz conditions to obtain the existence and
uniqueness of the solution in a Banach space specific to the derivative
of Caputo. The analytical study is followed by a complete numerical
study.
Novel biallelic mutations in TMEM126B cause splicing defects and lead to Leigh syndrome with severe complex I deficiency
Authors: Wang Ya , Zhou Xiyue , Lou Xiaoting , Zhou Yuwei , Xie Yaojun , Dong Qiyu , Ying Xiaojie , Laurentinah Mahlatsi Refiloe , Zhang Luyi , Chen Zhehui , Li Dongxiao , fang hezhi , Lu Jianxin , yanling Yang
Published: July 2022

Leigh syndrome (LS) is one of the most common mitochondrial disease
subtypes, caused by mutations in either the nuclear or mitochondrial
genomes. TMEM126B was identified as a mitochondrial complex I assembly
factor. Here, we identified a novel intronic mutation
(c.82-2A>G) and a novel exonic insertion mutation
(c.290dupT) in TMEM126B from a Chinese patient with clinical
manifestations of LS. In silico predictions, minigene splicing
assays and patients’ RNA analyses determined that the
c.82-2A>G mutation resulted in complete exon 2 skipping,
and the c.290dupT mutation provoked partial and complete exon 3
skipping, leading to translational frameshifts and premature
termination. Functional analysis revealed the impaired mitochondrial
function in patient-derived lymphocytes due to the complex I content and
assembly defect. Although TMEM126B mutations have been related to
multi-symptoms (exercise intolerance, severe muscle weakness,
hyperlactic acidemia, pure myopathy, chronic renal failure and
cardiomyopathy), we found the patient carrying these two mutations
developed an middle-onset LS. Altogether, this is the first report that
the patient carrying TMEM126B mutations was diagnosed with LS.
Our data uncover the functional effect and the molecular mechanism of
the pathogenic variants c.82-2A>G and c.290dupT, which
expand gene mutation spectrum of LS and clinical spectrum caused by
TMEM126B mutations.
A closed, autologous bioprocess optimized for TCR-T cell therapies
Authors: Stevens Jennitte , Liu Yijun , Zah Eugenia , Arbelaez Carlos , Kim Haejin , Gros Edwige , Buck Ranelle , Cox Kayley , Kim Sungeun , Kopp Martina , Henckels Kathryn
Published: July 2022

Autologous cell therapy has proven to be an effective treatment for
hematological malignancies. Cell therapies for solid tumors are on the
horizon, however the high cost and complexity of manufacturing these
therapies remain a challenge. Routinely used open steps to transfer
cells and reagents through unit operations further burden the workflow
reducing efficiency and increasing the chance for human error. Here we
describe a fully closed, autologous bioprocess generating MAGE-B2 TCR-T
cells. This bioprocess yielded 5 – 12e9 MAGE-B2-specific TCR-expressing
T cells, transduced at low MOIs, within 7 to 10 days, and cells
exhibited an enriched memory T cell phenotype and enhanced metabolic
fitness. It was demonstrated that activating, transducing, and expanding
leuko-apheresed cells in a single bioreactor without a T cell enrichment
step promoted lentivirus transduction efficiency while resulting in
comparable level of T cell purity (~97%) as that of
leukopak cells that went through CD8+ and CD4+ positive selection. The
critical process parameters of the bioreactor, including culturing at a
high cell density (7e6 cells/mL), adjusting rocking agitations during
phases of scale up, lowering glycolysis through addition of
2-Deoxy-D-glucose (2-DG), and modulating IL-2 levels, were shown to
positively regulate TCR expression and cell doubling time, and promote
resistance to effector-associated apoptosis of TCR-T cells. The
bioprocess described herein supports scale-out feasibility by enabling
processing of multiple patients’ batches in parallel within a Grade C
cleanroom.
A case of complex congenital heart malformation in an adult: double Inlet-Double Outlet Right Ventricle
Authors: Li Jing , Nie Fang , wang xiao
Published: July 2022

A 31-year-old woman was admitted to our hospital with progressive
intermittent headache, dizziness, nausea, and vomiting over two weeks.
BP: 120/78mmHg. Brain MRI considers brain abscess. Transthoracic
echocardiography (TTE) showed: Atrial ortho position, left ventricular
loop, enlarged right ventricle, narrow left ventricle, aorta in the
anterior left (AO=16mm), a pulmonary artery in the posterior right
(PA=35mm), both connected to the right ventricle, mitral and tricuspid
valves at the same level, both opening into the right ventricle, mitral
regurgitation (1+), tricuspid regurgitation (1+), Continuous
interruption of the upper interventricular septum, about 25mm in size;
The atrial septum is continuous and intact. The echo and opening of the
aortic and pulmonary valves were normal. Ventricular septum and right
ventricular wall thickened, left ventricular wall thickness normal
range, normal range of motion. No strange echo was observed in the
pericardium—Aorta right arch descending right (Figure 1). Ultrasonic
diagnosis: Complex Congenital Heart Disease: Right ventricular double
exports, in a double entry, abnormal arteries relations, a right aortic
arch, ventricular septal defect (pulmonary valve type), right
ventricular hypertrophy, left ventricular dysplasia, pulmonary
hypertension (semi), the proper ventricular systolic function is normal,
mitral valve regurgitation (1 +), tricuspid regurgitation (1 +), at the
same time further cardiac CTA confirmed echocardiographic diagnosis
(Figure 2).
SOCIALLY RESPONSIBLE INVESTING AS THE DI-RECTION OF CAPITAL MARKET DEVELOPMENT
Authors: Michalczuk Grażyna , Konarzewska Urszula
Published: July 2022

Socially responsible investing (SRI) is becoming an increasingly fast-growing segment of the capital market. It refers to transactions in which the investment objective is determined not only by financial criteria (expected rate of return and risk) but also by non-financial aspects related to environmental, social and corporate governance (ESG) issues. The aim of the article is to diagnose socially responsible investing in the capital markets in spatial terms. An additional aim is to identify the strategies implemented by investors in individual markets. The classical methods of research were used in this article, such as the study of the literature concerning socially responsible investing and the method of desk research based on documents showing global trends in socially responsible investing in terms of value and investment strategies used by investors. Referring to statistics, it can be seen that socially responsible investing becomes a significant form of locating funds in a global capital market. In 2020, the global value of the SRI market amounted to over USD 35 trillion. However, it is not a homogeneous market, as evidenced by the varying rates of development of socially responsible investing in different regions of the world. It is also a market that evolves in terms of the investment strategies used. This is reflected in moving away from making investment decisions mainly with the use of negative/exclusionary screening to investments made on the basis of ESG integration.
Simulation study of citric acid effects on pyrolysis of hydrochloric acid pickling waste liquor
Authors: Chao Lv , Hongxin Yin , Minghe Sun , Hangyu Zhu
Published: July 2022

During pyrolysis of hydrochloric acid pickling waste liquid in a Venturi
Reactor from iron and steel enterprises, the reaction products agglomera ted
and hindered product recovery. Addition of citric acid to materials at the
inlet improved product distribution. In this paper, a numerical simulation
of the combustion, phase change, and gas-solid chemistry involved in a
citric acid-added pickling waste liquid was conducted. These results showed
that citric acid added to the inlet resulted in a peak concentration of
carbon dioxide (CO2) in the back half of the venturi throat, and some ferric
oxide (Fe2O3) underwent a secondary reaction to afford ferroferric oxide
(Fe3O4). As the addition of citric acid increased, the flow of Fe2O3 at the
outlet first increased and then decreased, while the flow rate of Fe3O4
first decreased and then increased. When the ratio of citric acid was 7%,
the flow rate of Fe2O3 was the smallest and the flow rate of Fe3O4 was the
largest.
Effect of aspect ratio on coupled solute-thermocapillary convection instability in half-zone liquid bridge
Authors: Zou Yong , Huang Hulin , Ding Shoujun , Huang Xianshan , Ma Jianjun , Chen Hongmei
Published: July 2022

Floating zone method is an important technology for growth of high integrity and high uniformity single crystal materials due to its free of crucible contamination. However, capillary convection in the melt is a great challenge to floating zone crystal growth. In this paper, numerical simulations are performed to investigate the coupled solute-thermocapillary convection in SixGe1-x system of the half-zone liquid bridge. The impact of aspect ratio, As, is also investigated on stability of capillary convection. For As = 0.5, the results show that pure solute capillary convection is very weak, which presents 2-D axisymmetric structure. The temperature field is mainly determined by thermal diffusion, while the concentration field is dominated by convection and solute diffusion together. Coupled solute-thermocapillary convection exhibits 3-D periodic and rotating oscillatory flow with the azimuthal wavenumber m = 4, while the pure thermocapillary convection presents a 3-D steady non-axisymmetric flow while solute capillary convection is absent. This means that instability of convection will increase when two kinds of capillary convection are coupled. When the height of the liquid bridge is changed from 5 mm to 10 mm with a constant radius of 10 mm, azimuthal wavenumber, m, of coupled capillary convection shows a strong dependence on aspect ratio. The relationship between the azimuthal wavenumber and aspect ratio can be written as m ? As = 2 or m ? As = 2.2. Further results indicated that when velocity of the monitoring point is large, corresponding concentration is also high at that moment, but the phases of concentration and velocity are not completely synchronized.
Numerical simulation and experimental research of multi-pipe jet fireball
Authors: Tai Bin , Hao Xiaojian
Published: July 2022

This paper studies a self-designed high temperature fireball quasi-static simulation device to understand the temperature distribution of each substance inside the fireball under the multi-pipe injection technology. The changes in the physical field of the high temperature fireball are obtained through numerical simulation. The simulation model in this paper adopts the turbulent k-? model, and simulates the material transfer process according to Fick's law. The commercial software COMSOL multiphysics is used to give and analyze the local characteristics of fluid-flow and heat transfer. The simulation device formed a high temperature fireball under the interaction of the three-way jet fire. The experimental data verified the accuracy of the simulation results, and the experimental results were in good agreement with the simulation results. This method of analyzing the actual temperature field through simulation can be used to provide a powerful verification scheme for the detection of complex multi-temperature fields in the future.
Study on recovery and purification technology of sulfur hexafluoride gas under zero emission constraint
Authors: Zhang Lijun , Zeng Siming , Liu Kecheng , Han Hesong
Published: July 2022

In order to improve the efficiency of sulfur hexafluoride gas recovery and purification, an optimization method of technical parameters for sulfur hexafluoride gas recovery and purification based on quantitative characteristic parameter analysis is proposed. Combined with the reaction temperature, concentration of sulfur hexafluoride gas, concentration of SF6 gas, NOx, CO and other sulfur hexafluoride gas, the technical index constrained programming model of sulfur hexafluoride gas recovery and purification was established by using the equivalent constraint and zero emission constraint analysis method. Combined with the experimental test analysis method, the entropy weight characteristic analysis model of sulfur hexafluoride gas recovery and purification was established, and the quantitative parameter analysis of sulfur hexafluoride gas recovery and purification was carried out by combining the comprehensive index parameter analysis. The entropy weight analysis technology is used to analyze the influence of different recovery and purification parameters on the concentration of sulfur hexafluoride gas, and a quantitative analysis model of sulfur hexafluoride gas emission concentration is established. According to quantitative characteristic parameter analysis and data fusion technology, the technical parameters of sulfur hexafluoride gas recovery and purification are optimized. The experimental results show that by optimizing the technical parameters of sulfur hexafluoride gas recovery and purification, the content of toxic substances in sulfur hexafluoride gas is reduced, the effective separation capacity of sulfur hexafluoride is improved, and the energy cost is reduced.
Synergistic effect of potassium and calcium ions on coal pyrolysis behaviors: Experimental and kinetic model investigations
Authors: Liang Zhanwei , Qiao Jiafei , Yang Xin , Chen Hongwei , Zhang Zheng
Published: July 2022

A low rank coal was first used to investigate the synergistic effect of inherent and loaded potassium and calcium ions on the pyrolysis behaviors. The non-isothermal thermal analysis with higher heating rate to medium pyrolysis temperature was carried out by thermogravimetric analyzer for the selected raw and treated coal samples. Preliminary experiments conducted show that the particle size smaller than 160 mm can eliminate heat and mass transfer effect, and the most of volatile matter was released by heating the raw coal (R-coal) to 750?C. Moreover, the effect of heating rate, inherent and loaded potassium and calcium on moisture evaporation and devolatilization is systematically investigated, and the devolatilization index is introduced to estimate the activity of pyrolysis pr?cess. A comparison among the acid pickling coal (H-coal), acid pickling coal loaded with calcium (H-coal-C), and potassium (H-coal-P) shows that potassium and calcium have improved the inner water holding capacity. Finally, the influence of inherent and loaded potassium and calcium on the kinetic characteristics of volatile matter release stage was studied with Coats-Redfern integral method.
Fogs on the Yenisei River (Krasnoyarsk, Russia)
Authors: Shaparev Nikolai , Tokarev Alexey , Yakubailik Oleg
Published: July 2022

This work presents a study of the formation of cooling and steam fogs on the
Yenisei River during 2020. The formation of the above types of fogs resulted
from changes in the hydrothermal regime downstream the Krasnoyarsk
hydroelectric power station after its construction and it is also
associated with a combination of weather conditions and water temperature in
the river. Advective cooling fogs form in summer when moist air cools over
the surface of cold moving water. The formation of steam fogs in winter,
autumn and spring is associated with the cooling of water vapor above the
river surface by cold lower layers of air. The conditions for the formation
of fogs are analyzed depending on the air temperature and humidity, water
temperature, and wind speed. Based on the remote sensing data, the spatial
distribution of steam fogs along the river is determined.
The Effect of Alleged Financial Statement Fraud on Audit Fees and Short Interest
Authors: Lee Sam (Sunghan) , Rezaee Zabihollah
Published: July 2022

We examine auditors' consideration of audit risk information from the disclosure of alleged financial statement fraud (FSF) by investigating whether audit fees are higher for firms that allegedly committed fraud and for firms with ongoing FSF challenges and high short interest. We find a positive association between audit fees and FSF disclosures, and this association increases with the level of short interest. Auditors also consider ongoing FSF challenges reflected in the level of short interest when determining their audit fees. We find, however, that short sellers do not consider increased audit fees associated with the public disclosure of alleged FSF. Short sellers do not appear to contemplate audit fees and audit risk in analyzing the business risk of alleged FSF in determining their short positions. Our study has policy, practical, and educational implications for auditors, short sellers, and forensic accountants who investigate FSF.

Data Availability: The data used in this study are available from the sources identified in the study.

JEL Classifications: G32, M40, M42.
Exercise-Linked Skeletal Irisin Ameliorates Diabetes-Associated Osteoporosis by Inhibiting the Oxidative Damage–Dependent miR-150-FNDC5/Pyroptosis Axis
Authors: Behera Jyotirmaya , Ison Jessica , Voor Michael J. , Tyagi Neetu
Published: July 2022

Recent evidence suggests that physical exercise (EX) promotes skeletal development. However, the impact of EX on the progression of bone loss and deterioration of mechanical strength in mice with type 2 diabetic mellitus (T2DM) remains unexplored. In the current study, we investigated the effect of EX on bone mass and mechanical quality using a diabetic mouse model. The T2DM mouse model was established with a high-fat diet with two streptozotocin injections (50 mg/kg/body wt) in C57BL/6 female mice. The diabetic mice underwent treadmill exercises (5 days/week at 7–11 m/min for 60 min/day) for 8 weeks. The data showed that diabetes upregulated miR-150 expression through oxidative stress and suppressed FNDC5/Irisin by binding to its 3′-untranslated region. The decreased level of irisin further triggers the pyroptosis response in diabetic bone tissue. EX or N-acetyl cysteine or anti–miRNA-150 transfection in T2DM mice restored FNDC5/Irisin expression and bone formation. Furthermore, EX or recombinant irisin administration prevented T2DM-Induced hyperglycemia and improved glucose intolerance in diabetic mice. Furthermore, osteoblastic knockdown of Nlrp3 silencing (si-Nlrp3) or pyroptosis inhibitor (Ac-YVADCMK [AYC]) treatment restores bone mineralization in diabetic mice. Micro–computed tomography scans and mechanical testing revealed that trabecular bone microarchitecture and bone mechanical properties were improved after EX in diabetic mice. Irisin, either induced by skeleton or daily EX or directly administered, prevents bone loss by mitigating inflammasome-associated pyroptosis signaling in diabetic mice. This study demonstrates that EX-induced skeletal irisin ameliorates diabetes-associated glucose intolerance and bone loss and possibly provides a mechanism of its effects on metabolic osteoporosis.
Weight Cycling Impairs Pancreatic Insulin Secretion but Does Not Perturb Whole-Body Insulin Action in Mice With Diet-Induced Obesity
Authors: Winn Nathan C. , Cottam Matthew A. , Bhanot Monica , Caslin Heather L. , Garcia Jamie N. , Arrojo e Drigo Rafael , Hasty Alyssa H.
Published: July 2022

In the setting of obesity and insulin resistance, glycemia is controlled in part by β-cell compensation and subsequent hyperinsulinemia. Weight loss improves glycemia and decreases hyperinsulinemia, whereas weight cycling worsens glycemic control. The mechanisms responsible for weight cycling–induced deterioration in glucose homeostasis are poorly understood. Thus, we aimed to pinpoint the main regulatory junctions at which weight cycling alters glucose homeostasis in mice. Using in vivo and ex vivo procedures we show that despite having worsened glucose tolerance, weight-cycled mice do not manifest impaired whole-body insulin action. Instead, weight cycling reduces insulin secretory capacity in vivo during clamped hyperglycemia and ex vivo in perifused islets. Islets from weight-cycled mice have reduced expression of factors essential for β-cell function (Mafa, Pdx1, Nkx6.1, Ucn3) and lower islet insulin content, compared with those from obese mice, suggesting inadequate transcriptional and posttranscriptional response to repeated nutrient overload. Collectively, these data support a model in which pancreatic plasticity is challenged in the face of large fluctuations in body weight resulting in a mismatch between glycemia and insulin secretion in mice.