bluuebunny/crossref_metadata_2025 huggingface dataset:
Overexpression of S100A1 in Osteosarcoma Inhibits Tumor Proliferation and Progression
Authors: Xing Wenhua , Zhao Yanbin , Lin Liuwan , Zhao Zhenqun , Yang Mengchen , Wang Na , Cui Shuxia , Bai Rui , Zhao Aiqing
Published: December 2022

Background: Osteosarcoma is the most common primary malignant tumor of bone. Abnormal expression of S100A1 protein is closely related to the occurrence and development of malignant tumors. However, S100A1 in osteosarcoma has not been studied.
Methods: All osteosarcoma tissues were collected from patients who received surgical therapy at the Affiliated Hospital of Inner Mongolia Medical University, China in 2020. QRT-PCR and western blot assays were used to detect the expression of S100A1 in osteosarcoma tissues and cells. The negative effect of S100A1 on osteosarcoma cell growth was confirmed by vitro and vivo experiments.
Results: S100A1 inhibited the growth of osteosarcoma cells in vitro. Overexpression of S100A1 may inhibit the proliferation of osteosarcoma cells by preventing the activation of AKT signaling pathway by western blot assay. Finally, animal experiments confirmed that overexpression of S100A1 could inhibit the proliferation of osteosarcoma cells. Overexpression of S100A1 obtained better survival benefit in mice.
Conclusion: Our findings provided a new insight to the treatment of osteosarcoma. It also raised the possibility that S100A1 could be used in targeted therapies for osteosarcoma.
Trends in the Epidemiology of Brucellosis Cases in Iran during the Last Decade
Authors: Zeinali Mohammad , Doosti Sara , Amiri Behzad , Gouya Mohammad Mehdi , Nutifafa Godwin Gidiglo
Published: December 2022

Background: Brucellosis is one of the most important zoonotic diseases that impose a serious public health burden on some countries in the world. Annually, the WHO reports more than 500000 new cases of human brucellosis. The disease is endemic in most parts of Iran; especially, in areas where people live in close contact with infected animals. According to data from the Iranian Ministry of Health, the average incidence of brucellosis in Iran was 22 cases per 100000 population, with a decreasing trend of surveillance.
Methods: This cross-sectional survey was carried out within 2011-2020 in all provinces of Iran and from patients with clinical symptoms.
Results: During the last decade, a total of 173526 cases were reported from different provinces of Iran, with a higher frequency of occurrence in males (58.2%) living in rural areas (77%), as compared to those in urban areas (23%). Moreover, brucellosis was more common in the summer season (June) and most of the cases were via contact with infected livestock (91%) and consumption of unpasteurized dairy products (78% in rural areas and 76% in the urban areas).
Conclusion: The failure to effectively control brucellosis may be attributed to lack of knowledge about the disease, consumption of unpasteurized dairy and raw meat, lack of proper and safe vaccines for prevention and eradication programs, lack of rapid detection systems, and ineffective methods of isolating infected animals. Therefore, education and advancement of people’s knowledge are key to the prevention and control of the disease.
Risk Factors of Work-Related Head and Neck Injuries: A National Survey
Authors: Masinaei Masoud , Asady Hadi , Shahtaheri Seyed Jamaleddin
Published: December 2022

Background: Occupational accidents made injuries in different parts of the body; two important parts of them are head and neck. We aimed to identify the risk factors of work-related head and neck injuries with using of a nationwide occupational accident data.
Methods: This analytical cross-sectional study was conducted on the nationwide data that was gathered in 2013-2018. The target population was industrialized and non-industrialized adults, aged 18 yr or older. Dependent variable was the head and neck injuries. The independent variables were included, age, sex, education level, work experience, job, shift work, injury cause, referred center, season, accident day, accident time, and action after accident. Univariate logistic regression analyses and subsequently, a multivariate logistic regression model was used for analysis.
Results: Out of the 17066 injured workers, 4072 (23.86%) subjects had head and neck injuries. The results of multivariate logistic regressions model showed, age ranges 30-39 (OR = 1.218; 95% CI: 1.036,1.433; P= 0.017), 40-49 (OR = 1.313; 95% CI: 1.044,1.652; P= 0.020), and >= 60 (OR=1.620; 95%CI: 1.028,2.553; P=0.038) and having male sex (OR = 1.657; 95% CI: 1.075,2.555; P= 0.022) were final work-related risk factors of head and neck injuries in Iran. Also winter season (OR = 1.212; 95% CI: 1.00,1.469; P= 0.050) could increase the head and neck injuries odds.
Conclusion: Older workers in Iran are more vulnerable against the occupational head and neck injuries. Moreover, having male sex was other risk factor of the head and neck injuries.
A Patient with MELAS Syndrome Carried an M.3243A>G Mutation in Mitochondrial DNA and Multiple Nuclear Genetic Variants: A Case Report
Authors: Chu Xin , Dai Jie , Cui Hengxiang , Shen Hailin , Wu Qi , Zhu Xiangyang , Zhu Baofeng
Published: December 2022

We discuss the involvement of nuclear genetic variants correlating to observed phenotype in this case study. In January 2020, the 19-year-old boy from Nantong, Jiangsu Province, China with epilepsy symptom was identified to have myelin loss in the motor and sensory nerves in the electromyogram examination. Brain magnetic resonance imaging (MRI) demonstrated high-intensity areas of small multifocal gray matter regions in the bilateral temporal, parietal, and occipital lobes. In the serum of the patient, the levels of lactate dehydrogenase (LDH) and lactic acid were higher than the normal range values in multiple tests. By subsequent whole exome sequencing (WES) including analysis of the mitochondrial genome, the patient was revealed to carry an m.3243A>G mutation in mitochondria MTTL1 gene which was confirmed by direct Sanger sequencing analysis. Thus, disease of the patient was diagnosed as mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome. According to WES analysis, the patient also carried multiple homozygous variants, which correlating to myelinloss and epilepsy in nuclear genes. The peripheral neuropathy of the patient carrying single mitochondrial m.3243A>G mutation could be caused by multiple nuclear DNA defect.
Training in the Manufacture and Utilization of Black Garlic as an Immunity Booster During COVID-19
Authors: Lutfika Dewi Mentari , Ega Priani Sani , Muhammad Fakih Taufik , . Suwendar
Published: December 2022

Immunity is one of the most important things to considered when trying control the spread, and reduce the severity of COVID-19. There are many ways to boost the immune system. One method is the use of the herb Thibbun Nabawi, black garlic. Black arlic contains high levels of S-allyl cysteine. It is six times higher than raw garlic. This compound is known to increase the levels and activity of the immune components such as natural killer cell, cytokine. To increase immunity during the Covid-19 pandemic, a training program was conducted to increase knowledge surrounding the use of black garlic. The program was conducted in the Tamansari sub-district, Bandung and used the Training for Trainers (TFT) method. The evaluation of the training was carried out through pre-test and post-test questionnaires as well as through direct questions to participants. Results showed that there was an increase in public knowledge regarding the manufacture and utilization of black garlic to boost immunity. It was 33.546% and 47.151%, respectively.
Keywords: training, immunity, black garlic
Criteria for the Development and Evaluation of the Implementation of a Sustainable Pedestrian Bridge
Authors: Hendrawan H. , Amelia S.
Published: December 2022

The Pedestrian Bridge (Indonesian: JPO) is a vital facility to reduce traffic conflicts and accidents. There is a need to optimize the use of JPO while encouraging sustainable infrastructure development. This requires sustainability criteria. This study aimed to develop and evaluate the implementation of a sustainable JPO criteria in Indonesia by constructing an ”eco JPO” prototype in Surakarta City. A qualitative and quantitative descriptive questionnaire instrument in the form of a Likert scale was used, and further analysis was done using interest performance analysis. The results showed that two criteria must be met, namely, planning criteria and design criteria. Planning criteria included suitability to people’s needs and location. The design criteria included seven measures: attractive design, environmentally friendly, energy self-sufficient, safe, artistic, comfortable, and safe. Based on the evaluation of the design criteria, the overall JPO criteria relatively had the same importance value, namely ”important” with values between 4.47 - 4.85, and weights between 5.8% - 6.57%. The satisfaction aspect showed a somewhat similar value, namely ”satisfied” with the grade between 3.67 - 4.61, and weights between 5.45% - 6.73%.
Keywords: Sustainable, pedestrian bridge, criteria
The Improvement of the Dissolution and Release Characteristics of Ibuprofen Suppository Through Inclusion Complexes with
Authors: Darusman F. , I. Septian M. , Kartadarma E.
Published: December 2022

Ibuprofen is classified as a BCS class II because of its low solubility and high permeability. Inclusion complex formation using β-cyclodextrin is one method to increase a drug’s solubility. In addition to the method of increasing the solubility, the choice of dosage form and route of administration has a big role in the success of therapy because it can increase the onset of action of drugs while avoiding side effects. Rectal suppositories can provide a faster antipyretic effect than oral preparations. The purpose of this study was to determine the effect of inclusion complexes formation with β-cyclodextrin in increasing the dissolution rate and release characteristics of ibuprofen suppositories. The suppository formulation used various concentrations of cetylalcohol to increase the consistency of the cocoa butter base. The release characteristics of ibuprofen in suppositories were evaluated, including, organoleptic, melting time, weight diversity, dissolution rate and dissolution efficiency, by comparing ibuprofen inclusion complex suppositories with β-cyclodextrin all three mole ratios, namely 1:1, 1:2 and 2:1, to pure ibuprofen suppositories. The inclusion complex of ibuprofen with β-cyclodextrin at a mole ratio of 2:1 showed to increase the solubility and dissolution rate of ibuprofen in suppositories with good physical and release characteristics.
Keywords: ibuprofen, inclusion complexes, suppository
CENCHRUS LONGISPINUS (HACK.) FERNALD ON ANTHROPOGENICLY TRANSFORMED AREAS OF THE DNIESTER DISTRICT
Authors: Bondarenko О. Yu. , Myronov S. L.
Published: December 2022

During the study of flora of ecotopes of the railway tracks of the Dniester embankment, 14 localities of  the North American species Cenchrus longispinus  were identified. On the sand the plants are better  developed, have more lateral shoots. On crushed stone substrate, especially in the interrail space of  the railway, plants are low – 7 (10) cm high. In addition, Cenchrus longispinus on the Dniester  embankment was found in areas where no radical  transformation of the ecotope (beach) is detected.
Problem. The adventive species Cenchrus longispinus (Hack.) Fernald in Ukraine is at the expansion stage. It poses significant potential threat to the environment due to stress tolerance, wide ecological amplitude, high degree of naturalization, significant coenotic activity and so on. Much attention is now being paid to the study of the conditions for the emergence and naturalization of new adventitious species, especially quarantine ones.
Cenchrus longispinus originates from North America and is distributed with grain bulks. The species has spread to many countries - it has been found in South Africa, India, Moldova, Russia, in a number of European countries. Навести яких.
In Ukraine, the species was first detected in the southern regions. It is a kenophyte, agrio-epecophyte and belongs to the quarantine organisms that are partially distributed in Ukraine (A-2). In the ecological sense, the species prefers arid soil conditions. It is a heliophyte, in ecological and coenotic terms - a psammophyte. Most of its populations are concentrated in anthropogenic ecotopes.
Methods. In the summer of 2021, anthropogenically transformed areas of the Dniester embankment were surveyed by a route method. The flora of the railway tracks between the railway stations Karolinа-Bugas and Sonyachna was studied.
Results. 14 localities of Cenchrus longispinus were identified. Their coordinates are given in the publication. Plants are mostly localized in areas of unauthorized or organised pedestrian crossings over railway tracks. The substrate is crushed stone of railway tracks or adjacent sandy soil.
Conclusions. On sand plants, by sight, are better developed, have more lateral shoots, are higher. On the crushed stone substrate of railway tracks, especially in the interrail space, the plants are low - 7 (10) cm high. Specimens on both types of substrate, even those that undergo moderate and severe mechanical damage by pedestrians, possess a significant number of grown additional shoots. Almost all shoots have developed fruit.
Cenchrus longispinus on the Dniester embankment is represented not only in areas with strong anthropogenic impact, but also where human influence is moderate or apparently nonexistent. However, all surveyed areas are visited by pedestrians or vacationers.
Exploring the Correlation among Employee Performance, Motivation, and Social Life Satisfaction: A Study on Private Commercial Banks in Bangladesh
Authors: Shariful Islam Dr. Mohd.
Published: December 2022

As a key component of economic growth, commercial banks play a pivotal role in the development of trade and industry in a country. At present, 61 scheduled banks are operating in Bangladesh of which 43 are private commercial banks. The performance of these banks’ employees plays a vital role in the economic sustainability and growth of the country. This study focuses on these employees’ performance in the light of their motivation and social life satisfaction.  The data were collected from 204 respondents from the three renowned private commercial banks (Islami Bank Bangladesh Limited, Dutch-Bangla Bank Limited, and Jamuna Bank Limited) through a structured questionnaire. A 5-Point Likert Scale was used to collect primary data and Statistical Package for the Social Science (SPSS) software was used to analyze it. The study revealed that there is a significant positive correlation between employee performance and motivation as well as social life satisfaction. Furthermore, social life satisfaction has the highest positive contribution to performance. Finally, some actionable recommendations were outlined based on the findings of the study.
Necrosis uterina tras sutura de compresión hemostática: reporte de caso y revisión de la literatura
Authors: García-Guerra Raquel , Assaf-Balut Myrna , El-Bakkali Sara , Pérez de Ávila-Benavides Irene , Huertas-Fernández Miguel Ángel
Published: December 2022

Objetivos: presentar un caso de necrosis uterina tras técnica de sutura hemostática por hemorragia posparto y hacer una revisión de la literatura para determinar la técnica de sutura utilizada, los hallazgos clínicos, la técnica diagnóstica y el tratamiento realizado en los casos clínicos descritos. Materiales y métodos: se presenta el caso de una mujer de 34 años que consultó por dolor abdominal al octavo día tras cesárea por placenta previa, que precisó sutura de B-Lynch por atonía uterina y cuyo diagnóstico fue necrosis uterina. La paciente requirió histerectomía abdominal total, con evolución satisfactoria. Se realizó una búsqueda sistemática de la literatura en las bases de datos Medline vía Pubmed, Embase y Web of Science. Se buscaron series y reportes de casos y cohortes de mujeres con necrosis uterina posterior al uso de suturas de compresión uterina para control de hemorragia posparto. Se analizaron variables sociodemográficas y clínicas al diagnóstico, técnica de sutura, pruebas diagnósticas y tratamiento. Resultados: se incluyeron 23 estudios con 24 pacientes. El 83 % de las necrosis ocurrieron tras cesárea. La técnica más utilizada fue B-Lynch (66 %), seguida de Cho (25 %). Los síntomas más frecuentes fueron fiebre y dolor abdominal. La prueba diagnóstica más utilizada fue la tomografía computarizada (9 de 24 casos). En la mayoría de casos se realizó histerectomía (75 %). Conclusiones: la necrosis de la pared uterina es una complicación infrecuente pero grave. Sería recomendable el diseño de cohortes de seguimiento de mujeres sometidas a estos procedimientos para determinar la incidencia de complicaciones asociadas.
Centaurea ptosimopappa var. elegans Güzel. A New Centaurea L. (Asteraceae) taxa from Turkey with taxonomical notes on sect. Ptosimopappus and with lectotypification
Authors: GÜZEL Yelda
Published: December 2022

A new variety of Centaurea (Asteraceae) section Ptosimopappus from the Amanus Mountains, South Anatolia was described. The new taxon is considered as a variety of C. ptosimopappa due to shared morphological characters such as sterile and fertile leathery basal rosettes and branched shrub habits. On the other hand, it differs by achene morphology and by involucre, spinule and cauline leave sizes as well as other morphological and anatomical differences. Detailed morphological, carpological and microsculptural analyses were carried out in order to reveal the differences between the variety. Also, Lectotype for C. ptosimopappa var. ptosimopappa based on isotypes of its basionym Ptosimopappus bracteatus was designated
Ege Bölgesi Bağ Alanlarında Fitoplazma Hastalıklarının ve Olası Vektör Böcek Türlerinin Belirlenmesi
Authors: ERİLMEZ Serpil , KAYA Aydan , ÜSTÜN Nursen , GÜVEN Neziha , ALTINDİŞLİ Ferhunde Özlem , ÖZSEMERCİ Fatma
Published: December 2022

Bu çalışma 2013-2015 yıllarında, Ege Bölgesi’nde Çanakkale, Denizli, İzmir ve Manisa illerinde bağlarda fitoplazma hastalık etmenleri Candidatus Phytoplasma vitis (Flavescence doree (FD)) ve Candidatus Phytoplasma solani (Bois noir (BN)) moleküler yöntemlerle belirlemek amacıyla gerçekleştirilmiştir. Çalışma alanını kapsayan 4 ilin, 13 ilçesindeki 119 bağda Eylül-Kasım aylarında tesadüfi örnekleme yöntemine göre sürveyler gerçekleştirilmiştir. Survey alanında gelişme geriliği, yapraklarda renk değişikliği, kızarma, sararma, içe ve aşağı doğru yaprak kıvrılması, düzensiz olgunlaşma belirtileri gösteren toplam 194 asmanın yıllık sürgünlerinden yaprak ve sürgün örnekleri alınmıştır. Hastalık etmenlerinin tanılanması moleküler yöntemler kullanılarak yapılmıştır. Multiplex nested PCR yöntemiyle yapılan tanılamada 22 adet örnek FD’nin yer aldığı 16 Sr V grubu, 14 örnek ise BN’nin bulunduğu 16 Sr XII grubu için pozitif reaksiyon vermiştir. Yapılan çift yönlü DNA sekans analizinden elde edilen verilerin NCBI-BLAST analizine göre 16 Sr V grubuna ait olduğu belirlenen 22 adet izolat gen bankasında kayıtlı Candidatus Phytoplasma vitis izolatları ile % 97’nin altında benzerlik gösterdiğinden tür düzeyinde bu etmenin varlığı doğrulanmamıştır. Öte yandan, 16 Sr XII grubunda yer alan 14 adet izolatın 2 adedi gen bankasında kayıtlı Candidatus Phytoplasma solani (BN) izolatları (Acc. No. JQ977744.1) ile % 99 benzerlikte saptanmış ve bu izolatlar Candidatus Phytoplasma solani olarak tanımlanmıştır. Söz konusu 2 izolat Denizli ili Bekilli ilçesinden alınan örneklerdir. Vektör böceklerin saptanabilmesi amacıyla, hastalık etmenlerinin tespit edildiği bitkilerde görülen Hemiptera takımına ait böcekler toplanmıştır. Teşhis sonucunda çalışmada elde edilen türlerin fitoplazma hastalığının vektörü olduğu bilinen türlerden farklı olduğu belirlenmiştir. Ege Bölgesi bağ alanlarında BN saptanmasına rağmen yayılmasında etkili olan vektör böceklerin bu alanlarda bulunmadığı ortaya koyulmuştur.
POLÍTICAS PÚBLICAS DE BIBLIOTECAS, LEITURA E ESCRITA NO BRASIL
Authors: Ferreira Maria Mary , Martins Carlos Wellington
Published: December 2022

O artigo discute políticas de bibliotecas, leitura e informação na construção de um Estado Nação. Reflete como a leitura e a informação se constituem canais para construção de sujeitos politicos e como esta perspectiva foi pensada nos governos de Luiz Inácio Lula da Silva e Dilma Rousseff com a implementação do Plano Nacional do Livro e da Leitura criado em 2006 e esvaziado nos governos de Temer e Bolsonaro. Observa que a falta de informação, pobreza e analfabetismo de um País, atinge em proporções agudas o acesso à informação através de serviços adequados de bibliotecas públicas, o que se constitui uma necessidade urgente, porém a total desarticulação do PNLL contribuiu para a descontinuidade desta política, interferindo na construção do Estado de Direito cuja dimensão é democrática, não condiz com autoritarismo e prescinde de programas de leitura e informação para se consolidar
PANC como ferramenta de ensino na Educação Ambiental Crítica
Authors: Guimarães Juliana , Mello Nilvania Aparecida de , Pereira Giovana Faneco
Published: December 2022

A Educação Ambiental Crítica precisa ser incorporada na prática pedagógica dos professores, sendo essencial a utilização de estratégias que façam parte do contexto dos indivíduos. As Panc (Plantas Alimentícias Não Convencionais) destacam-se como importantes ferramentas de ensino, pois possibilitam, entre outros, a valorização dos saberes, promovem a diversidade, segurança e autonomia alimentar, além disso, permitem deduzir as características e condições do solo. O objetivo geral deste trabalho é demonstrar a importância das Panc como ferramenta de ensino na Educação Ambiental Crítica. Enfatiza-se que por meio das oficinas pedagógicas, foi possível constatar que as Panc tem um potencial significativo como ferramenta de ensino, no entanto, é primordial investir na formação continuada dos docentes que atuam desde a Educação Infantil até o Ensino Superior, para que assim os mesmos estejam aptos e sintam-se seguros para atuarem como agentes multiplicadores do conhecimento.
A necessidade de ratificação da convenção 190 da organização internacional do trabalho pelo Brasil
Authors: Fontoura Isadora Hörbe Neves da , Reis Suzéte da Silva
Published: December 2022

O presente artigo tem como objetivo analisar a necessidade de ratificação da Convenção 190 da Organização Internacional do Trabalho pelo Brasil. Nesta seara, faz-se necessário responder ao seguinte questionamento: Por quais razões o Brasil deve ratificar a Convenção 190 da Organização Internacional do Trabalho? O método que será utilizado no estudo será o dedutivo, o método de procedimento utilizar-se-á o bibliográfico e às técnicas de pesquisa serão realizadas por meio de pesquisa bibliográfica em livros, revistas, periódicos, notícias e dissertações. A Convenção 190 da OIT tem por finalidade erradicar o assédio moral e o assédio sexual na vida de todos os trabalhadores. Dados e pesquisas comprovam que o Brasil é um país que possui este fenômeno com muita presença e, por esta razão, é inquestionável que ele deva ratificar a mencionada Convenção para que possa diminuir os casos de assédio e permitir que os trabalhadores possuam uma vida tranquila.
IDIOSSINCRASIAS NIILISTAS NO SERTÃO BAIANO: Wilson Lins e as políticas da 'Boa vontade”
Authors: Rosa Roberto Sávio
Published: December 2022

O objetivo do presente ensaio é apontar como intuições Filosófico-literárias conseguiram arrebatar, por meio de lampejos e traços, o inefável descomunal partícipe da condição humana e como o esforço empregado, na busca por definições e aclaramentos, pavimentou e familiarizou, às avessas, os pastores do povo quanto à triste valoração dos caracteres que insistem em dissimular. Para a execução do propósito requeremos o auxílio da cartografia singular de nautas corajosos. A navegação empreendida objetiva singrar os mares inóspitos do niilismo de Dostoievski a Nietzsche em direção ao ancoradouro receptivo de Wilson Lins.
DE BUTLER A FOUCAULT: um ensaio sobre a transformação crítica de nós mesmos
Authors: Stephan Cassiana Lopes
Published: December 2022

No presente ensaio, revisitamos a atitude crítica, concebida por Foucault como a arte da inservidão voluntária e da indocilidade refletida, sob a luz da tematização butleriana da responsabilidade ética e da vida psíquica do poder. Por meio deste movimento analítico, que nos desloca de Butler a Foucault, compreendemos que a transformação crítica de nós mesmos depende da mobilização estratégica do mundo plural de cuja experiência desponta a prática da autarquia tal que implicada à responsabilidade ética pelo presente, pelos outros e pelo mundo. Ademais, partindo de Butler em direção a Foucault, somos capazes de entrever a dimensão criativa da crítica que se atrela à estética da existência e que, na via do mundo plural, ativa um conjunto de tecnologias que subvertem a lógica sacrificial da constituição das identidades. Portanto, neste ensaio, buscamos mostrar que a crítica viabiliza a modificação do si na medida em que o vincula ética e politicamente aos outros e ao mundo.
A DIMENSÃO COMUNITÁRIA DA CRÍTICA DA RAZÃO NA FENOMENOLOGIA: Ciência, mundo da vida e história
Authors: Madalosso Yuri , Santos Eder Soares
Published: December 2022

Neste artigo, o objetivo geral é elucidar a “crítica da razão” enquanto tarefa ampla na fenomenologia, assim como sua dimensão histórica e comunalizada. Enquanto objetivos específicos, busca-se explicar os pressupostos epistemológicos e a própria noção de fenomenologia implicada na crítica histórica do mundo da vida. Além disso, iremos clarificar a noção de justificação e de autorresponsabilidade como correlatas na crítica fenomenológica. Por fim, mostraremos que a crítica histórica e à tradição pressupõem um desenvolvimento dinâmico, mas desigual que se inicia na primeira filosofia husserliana. Nossa hipótese de interpretação é de que, se Husserl pensa a fenomenologia como tarefa infinita historicamente desenvolvida e crítica às tradições, ela o é no sentido de uma crítica global à razão a partir de um conceito amplo de “ciência”. Para defendê-la, iremos explicitar como, desde as Investigações lógicas, o conceito de “crítica do conhecimento” foi se transformando, paulatinamente, na fenomenologia como filosofia crítica da razão teórica, prática e valorativa, enquanto uma práxis racional da vida autorresponsável.
MOVILIZACIÓN CLIMÁTICA URBANA Y PODERES SALVAJES: EL PAPEL DE LOS DERECHOS HUMANOS EN LA DEFENSA DE BIENES COMUNES
Authors: Hincapié Sandra
Published: December 2022

En este artículo se analiza el papel que han tenido los derechos humanos en movilizaciones climáticas urbanas para la protección de ecosistemas de páramos, característicos de la Cordillera de los Andes y considerados bienes comunes. Através de un estudio de caso profundizo en el análisis de la movilización y el papel que han jugado las ideas y mecanismos de derechos humanos. Específicamente examino el comportamiento y prácticas en losmecanismos de transparencia/rendición de cuentas y arbitraje del Banco Mundial, al comparar la movilización sociolegal en los litigios a nivel interno con dinámicas de movilización transnacional y los mecanismos extraterritoriales de resolución de conflictos.
DECRESCIMENTO DA ECONOMIA E BENS COMUNS: UMA AGENDA PARA A CRISE SOCIOAMBIENTAL
Authors: Walmrath Lucas Lemos
Published: December 2022

Resenha sobre o livro:  HICKEL, J. Less is more: how degrowth will save the world. Londres: William Heinemann, 2020. Versão ebook.
O exercício da docência em um contexto de reformas educacionais
Authors: Alves Maria Aparecida
Published: December 2022

O presente artigo tem por objetivo analisar a interface entre as recentes reformas educacionais e o trabalho docente, bem como suas implicações sobre a formação de professores da educação básica. Este tema insere-se no atual contexto de mercantilização e privatização na área da educação, em que os agentes privados têm ampliado seu poder de influência sobre a esfera educacional e, com isso, passam a interferir nas políticas públicas de educação, como é o caso das propostas de reformas nessa área. O foco da análise são as mudanças mais recentes propostas para o sistema educacional, tendo como recorte a Reforma do Ensino Médio (Lei 13.415/2017), a Base Nacional Comum Curricular (Resolução nº 4 de 2018) e a Resolução CNE/CP nº 2/2019, que institui a Base Nacional Comum para a Formação Inicial de Professores da Educação Básica (BNC-Formação). Parte-se da hipótese de que a implementação destas reformas intensifica o quadro de precarização das condições de trabalho, da carreira e da formação docente. Dentre os principais resultados da análise, observou-se que estas reformas têm levado à desvalorização do saber docente e do trabalho intelectual, ao esvaziamento da formação de professores, à redução de trabalhadores qualificados e à precarização do trabalho docente. Este trabalho se baseia no referencial teórico e metodológico do materialismo histórico-dialético e apoia-se nas áreas da Sociologia da Educação e do Trabalho.
O postítulo em literatura infantil e juvenil da cidade de Buenos Aires
Authors: Lima Sheila Oliveira
Published: December 2022

Este artigo descreve e analisa uma experiência de formação continuada realizada pela Escuela de Capacitación do Centro de Pedagogías de Antecipación do governo de Buenos Aires, entre os anos 2000 e 2011. Trata-se de um curso de especialização em literatura infantil e juvenil, direcionado a professores e bibliotecários da capital argentina, que alcançou resultados muito relevantes, tendo baseado suas atividades em uma perspectiva dialógica de ensino. A partir de uma prática etnográfica, este estudo articula diversas fontes de informação sobre o Postítulo en literatura Infantil y Juvenil, como forma de reconhecer os elementos que favoreceram o sucesso da experiência formativa. Conclui-se que os elementos distintivos do processo analisado fundam-se na prática da conversação como metodologia e na consequente constituição de uma rede-de-afetos, demarcada pela coesão ética entre os participantes.
A formação continuada de professores pedagogos paranaenses do município de Almirante Tamandaré com vistas ao seu desenvolvimento profissional
Authors: Scholochuski Virginia do Carmo Pabst , Hagemeyer Regina Cely de Campos
Published: December 2022

O presente artigo integra a uma das categorias de análise de uma tese de doutorado intitulada como: A formação e a identidade do professor pedagogo da rede estadual do Paraná: implicações para o desenvolvimento profissional no contexto da escola básica contemporânea. Seu objetivo é analisar as atividades de formação continuada ofertadas aos professores pedagogos das escolas estaduais localizadas no município de Almirante Tamandaré, para identificar de que forma elas contribuem para a sua atuação e desenvolvimento profissional na escola básica. Para conceituar e analisar formação continuada e desenvolvimento profissional do pedagogo apoiou-se em Marcelo Garcia (1999, 2009), André (2010), Nóvoa (2008), Imbernón (2002, 2010) e Fiorentini (2013).  Para discutir sobre a função do pedagogo escolar nas unidades educativas, utilizou-se das contribuições de Libâneo (2006 e 2010), Franco (2003) e Placco e Souza (2008). A abordagem metodológica escolhida foi a da pesquisa qualitativa e as técnicas de coletas de dados utilizadas foram: questionários aplicados aos professores pedagogos que atuam nas escolas estaduais do município de Almirante Tamandaré – PR, entrevistas semiestruturadas, observação participante dos cursos destinados aos professores pedagogos e análise documental. Assim, verificou-se que os encontros formativos disponibilizados pela SEED-PR e comprometidos com o desenvolvimento profissional devem promover a escuta dos professores pedagogos para a planificação do curso, levando em consideração as suas necessidades profissionais específicas, e investindo em estudos, grupos de pesquisa e redes de comunicação profissional, a partir de interesses e necessidades locais e contextuais, que levam ao incentivo e investimento em estudo e na pesquisa.
Entrevista com a Professora Dra. Márcia de Souza Hobold: “Formação continuada de professores da educação básica: investimento no processo de emancipação humana”
Authors: Romanowski Joana Paulin , Damião Maria Helena , Nascimento Ilma Vieira do
Published: December 2022

A entrevista desse dossiê, que focaliza a “Formação continuada de professores da educação básica: investimento no processo de emancipação humana”, foi concedida pela professora doutora Márcia de Souza Hobold às organizadoras do dossiê Joana Paulin Romanowski (UNINTER, Brasil), Maria Helena Damião (FPCE-UC. Portugal) e Ilma Vieira do Nascimento (UFMA, Brasil) e realizada por Joana Paulin Romanowski. O dossiê focaliza  a formação continuada por princípios de emancipação do trabalho do professor, no acolhimento da reflexão crítica para promover a profissionalização dos professores. Márcia de Souza Hobold é formada em Pedagogia e Psicologia, fez especialização em Psicopedagogia, tem mestrado e doutorado em Educação, e estágio de pós-doutoramento na PUCSP. É professora na Universidade Federal de Santa Catarina (UFSC) na disciplina de Didática nos cursos de licenciatura e na disciplina de Formação de Professores no Programa de Pós-Graduação em Educação da UFSC. Foi professora da educação básica por dezenove anos, lecionando desde os anos iniciais do ensino fundamental até a atuação na coordenação pedagógica do ensino médio. É bolsista de produtividade em pesquisa pelo CNPq – bolsa PQ. Tem uma atuação em pesquisa no campo de formação de professores, com participação em associações (ANPEd, ANFOPE, RIPEFOR) e grupos de pesquisa marcada por colaboração e voluntariado na coordenação e comitês científicos.
Prospects for the treatment of gluten-associated diseases: on our daily bread, celiac disease, gluten proteins and more…
Authors: Bakulin Igor G. , Avalueva Elena B. , Semenova Elena A. , Оrеshkо Ludmila S. , Serkova Margarita Y. , Sitkin Stanislav I.
Published: December 2022

Food safety all over the world is largely dependent on production of grains that are cultivated in 60% of agricultural lands. Wheat is the main food for millions of people and one of the three most commonly cultivated grain cultures worldwide, along with corn and rice. Modern wheat is a product of gene engineering interventions aimed at increased productivity, yields, nutrient quota, and storage time, as well as immunogenic properties. However, the consumption of gluten, a proline and glutamine-rich wheat, rye and barley protein, triggers gluten-dependent disorders, such as celiac disease, wheat allergy, baker's asthma and wheat-dependent exercise-induced anaphylaxis. This group of disorders are curable provided the correct diagnosis has been made and strict lifelong gluten-free diet is implemented. Continuous patient's adherence to the gluten-free diet is associated with a number of medical and paramedical challenges, and the adherence level of the most compliant patients does not exceed 80%. The paper discuss other treatment strategies to improve the nutrition of people with gluten-sensitive disorders, in particular, the reduction grain gluten content, gluten sequestration in the gut before its digestion, prevention of gluten absorption and subsequent immune cell activation, and administration of tissue transglutaminase 2 inhibitors.
Actinic keratosis as a predictor of primary multiple synchronous squamous cell skin cancer: a clinical case
Authors: Sedova Tatiana G.
Published: December 2022

We present a clinical case of a primary multiple synchronous highly differentiated keratinizing squamous cell skin cancer in an 84-year old patient with multiple actinic keratosis and actinic cheilitis. The clinical case is unique for the simultaneous development of primary multiple squamous cell carcinoma of the tip of the nose and the vermilion zone of the lower lip in a patient with a past occupational and solar burden, a light phenotype, and signs of chronic photo injury the skin. Clinical, dermatoscopic and sonographic signs of keratotic actinic keratosis were identified in the patient and confirmed by pathomorphological examination. The risk factors for malignant transformation of actinic keratosis were found, such as multiple efflorescences and a long disease history. The malignant transformation of the actinic areas manifested as rapidly progressive ulceration zones more than 1 cm in diameter, pronounced hyperkeratosis, inflammation and infiltration of the underlying tissues, increased bleeding and pain. It is to be underlined that definitive and differential diagnosis requires pathomorphological assessment of the skin biopsy sample. This clinical case indicates that patients with multiple foci of actinic keratosis should be under a lifelong follow-up by dermatovenereologists, with mandatory treatment and prevention measure.
Os sócios dos escritórios estabelecidos
Authors: Visser Ricardo , Siqueira Gustavo
Published: December 2022

o artigo faz uma análise de oito entrevistas semiestruturadas com advogados empregadores e com rendimentos de alto volume. A investigação focaliza em três principais eixos: a) a origem social e ingresso na advocacia; b) o perfil da clientela e formas de inserção profissional; c) prestação de serviços e passagem por carreiras de Estado. No primeiro quesito, delimitou-se três padrões de influência familiar: a direta, na qual o contexto familiar define as possibilidades de carreira do entrevistado; indireta, na qual há influência, mas o entrevistado se coloca como independente; e a reprodução de um contexto familiar favorável ao sucesso escolar, mas sem uma ingerência específica. No que concerne ao perfil da clientela, observamos que nessa predomina clientes empresariais. Neste âmbito, foi possível detectar a mobilização de capitais políticos e sociais, além da competência jurídica. Por fim, foram analisadas passagens por cargos em órgãos estatais. Ainda que não constitua regra geral entre os entrevistados, sua ocorrência também é acidental.
Modern development of the agro-industrial complex of the northern region of Russia on the basis of public-private partnership
Authors: Yudin A. , Tarabukina T. , Saenko I.
Published: December 2022

The article discusses the mechanisms of interaction between government and business in the form of public-private partnership in the field of agricultural production of the Komi Republic and the Kostanay region of the Republic of Kazakhstan. The paper analyzes the program-target approach implemented through regional and departmental target programs, including through the State Program for the development of agriculture and regulation of agricultural products, raw materials and food markets. The strategy of socio-economic development for the period up to 2035 is presented, one of the priorities of which is to ensure stable economic growth, including the development of the territory of the smart agro-industrial complex, providing the population with its own high-quality and environmentally friendly products. Its main measures and tasks for the implementation of the policy in this direction are outlined.

The most important tool for implementing the Strategy is considered, particularly the state program of the Republic of Komi “Development of agriculture and regulation of agricultural products, raw materials and food markets, development of the fisheries complex”, approved by the Decree of the Government of the Republic of Komi dated October 31, 2019 № 525, which has its own conditions, features and targets. The actual data on the state of agriculture in the Komi Republic for 2018-2021, the level of self-sufficiency in the main types of agricultural products, the production of agricultural products, the level of average monthly wages of agricultural workers, the level of profitability of goods sold (works, services) are presented.

The conclusion is made about the importance of state support and regulation of the agricultural sector.
Assessment of potato varieties and variety samples selected by the Ural Research Institute of Agriculture from the collection of the A.V. Zhuravsky Institute of Agrobiotechnologies FRC Komi SC UB RAS
Authors: Bykov S. , Turlakova A. , Zaynullin V.
Published: December 2022

The article discusses the results of testing varieties and variety samples of potato selected by the Ural Research Institute of Agriculture. By the obtained data of 2021, the microclonal propagation is an efficient method in terms of tuberization, as evidenced by the weight ratio of potato tubers to tops (it is comparatively high in the yield of minitubers (p≤0.05)) with domination of first fraction tubers (tubers weighing more than 80 g). According to the assessment of varieties and variety samples of 2021-2022, the study early and early-ripening varieties are dominated by the Meteor and Terra varieties being noticeable through early yield (in 65 days) and marketability (more than 80%). These varieties yield more than 20 t/ha. The Terra, Meteor, Shakh, Mishka varieties and the 14-27-6 variety sample showed a high overall yield of more 36 t/ha.
Using GPS-Paradata to Control the Data Collection Process: Review of Existing Methods and Analysis of GPS-Paradata Quality
Authors: Lebedev Daniil
Published: December 2022

The use of face-to-face interviews is still a very common data collection method in social sciences. The danger associated with the use of such data collection methods is a reduction in the resulting survey data’s quality due to interviewers’ fabrications or falsifications, which in turn has led to the emergence of a large set of methods for controlling the data collection process, the focus of which is limited and bypasses the behavioral characteristics of interviewers. In this context, paradata and GPS-paradata are an important new tool for use in the process of quality control of collected data or as part of a methodological audit, allowing not only to potentially identify and prevent falsification or fabrication by interviewers, but also to assess the correctness of methodological instructions. This article provides an overview of the available and practiced methods for using GPS-paradata in two main strategies (data point analysis and interviewer path analysis): geofencing, strand length, curbstoning, connecting interviews’ locations and interviewer path analysis. The possibilities of using such control methods depend on the sample design and on the methodological features of the surveys in general. However, the use of GPS-paradata to control the data collection process is not in itself a surefire method for detecting interviewers’ fabrications or falsifications, as it may be subject to technical inaccuracies or unintentional interviewer errors. It is a useful additional method aimed at identifying “suspicious” interviews which require the use of more resource-intensive methods of control (for example, repeated contact). In addition, the article presents an analysis of the quality of acquired GPS-paradata on the example of 26th wave of the RLMS-HSE, based on analyzing missing data and quality of measurements (HDOP). The results show that the quality of GPS-paradata can be related both to the region where the interview is conducted and to the characteristics of the interviewers.
The Characteristics of Social Service in Different Types of Settlements: As Seen by Consumers of Services (Based on the Results of an all-Russian Survey)
Authors: Arkhipova Elena , Borodkina Olga
Published: December 2022

Today the system of social services is being transformed, the number of social service providers is growing, and new forms of interaction with recipients of social assistance are being introduced. A special role in the new configuration of the social service system is given to socially oriented non-profits and social entrepreneurs. This article presents the results of a study of the social service system from the viewpoint of recipients of social services. The main method for collecting information was an all-Russian online survey among social service clients or their representatives. The research methodology involved distinguishing 5 clusters according to type of settlement (megacities, cities with a million-plus population, large cities, small towns and rural areas). The sample consisted of 2267 people. Based on the results of the study, main groups of social services in various types of settlements were proposed. The results showed a lack of development of the non-state service sector in all identified clusters. Barriers preventing the involvement of NGOs in the social services system are associated, on the one hand, with the conviction of the citizens themselves (especially the older generation) that only state institutions can provide quality and free services. On the other hand, many NGOs do not want to be listed in regional registries of social service providers, primarily due to low tariffs, reporting mechanisms and cost recovery. Residents of small towns and rural areas often face a lack of choice, the dominance of one type of provider, underdeveloped social infrastructure in their area, and a limited list of services available to them free of charge.
A “Prophet” in the Country of “Pharisees”. “Social and cultural dynamics” by Pitirim Sorokin and its Critics. Article 1. Pitirim Sorokin and Alexander Goldenweiser
Authors: Sapov Vadim
Published: December 2022

The article is devoted to the history of the controversy that arose after the publication of the first three volumes of “Social and Cultural Dynamics” by Pitirim Sorokin and American anthropologist Alexander Goldenweiser. The reasons why Sorokin’s work was rejected by academic American sociology are analyzed. A full list of reviews on “Dynamics” is provided that was published by international media in 1937–1942. The possible causes of the conflict that broke out between Sorokin and Goldeneizer over the authorship of the “principle of limited opportunities” or the “principle of limit” are analyzed. The appendix to the article includes Goldenweiser’s review of Sorokin’s “Dynamics”, written in the form of a “platonic dialogue”, and Sorokin’s response to it, translated to Russian for the first time.
Being a Muslim In a Catholic Family and Vice Versa: Religious Education in Mixed-Faith Families in Flores, Eastern Indonesia
Authors: Widyawati Fransiska
Published: December 2022

This study explores religious education and identity formation among families within mixed-faith families in Flores, Eastern Indonesia, specifically, Muslim-Catholic families. This ethnographic research observes and holds in-depth interviews with eight mixed-faith families comprising four to eight family members. This study finds that mixed-faith families continue to carry out the process of faith education and identity formation for all their members. However, the presence of family members with different religions gives a distinctive character because there are always negotiations, adaptations, and even transformations. The form, intensity, and model of faith education between families differ depending on the context of a mixed-faith family formation, one's position and power in the family, one's way of thinking about religion, and the spiritual environment around the family. Faith education in a mixed-faith family can positively deepen faith, strengthen religious identity, increase knowledge about other religions, foster tolerance, and appreciate diversity. This can also fade away the identity and belief of the minority and even can lead to conversion. However, the bond of family love does not cause differences, fights and conversions into one meaningful conflict.