bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH FASILITAS BELAJAR TERHADAP MOVASI BELAJAR SISWA KELAS XI IPS SMA NEGERI 1 KRAKSAAN PROBOLINGGO TAHUN 2018
Authors: Yugiswara Anton , Sukidin Sukidin , Kartini Titin
Published: April 2020

Tujuan penelitian ini adalah untuk mengetahui adakah pengaruh yang signifikan fasilitas belajar terhadap motivasi belajar siswa kelas XI IPS SMA Negeri 1 Kraksaan Probolinggo tahun 2018. Penelitian ini merupakan penelitian kuantitatif. Penentuan lokasi penelitian menggunakan metode purposive area, sedangkan responden sebanyak 105 (3 kelas) responden. Metode pengumpulan data yang digunakan terdiri dari metode: angket dan wawancara. Analisis data yang akan digunakan yaitu analisis inferensial (yang terdiri: analisis garis regresi linier sederhana dan uji F). Hasil analisis menunjukkan F hitung = 470,104 > F tabel = 3,93 dengan σ = 0,05 > Sig F 0,000 artinya variabel bebas  Fasilitas Belajar yang terdiri dari indikator ruang, media informasi, dan buku berpengaruh signifikan terhadap variabel terikat motivasi belajar siswa kelas XI IPS SMA Negeri 1 Kraksaan Probolinggo.
PENERAPAN MODEL PROBLEM BASED LEARNING (PBL) UNTUK MENINGKATKAN MINAT DAN HASIL BELAJAR SISWA (Studi Kasus Pada Siswa Kelas VIII di SMP Plus Sunan Drajat Jember Mata Pelajaran IPS Kompetensi Dasar Mengidentifikasi Bentuk Pasar Dalam Kegiatan Ekonomi Masya
Authors: Saiful Rizal M. , Kantun Sri , Kartini Titin
Published: April 2020

Penelitian ini bertujuan untuk meningkatkan minat dan hasil belajar siswa dengan menerapkan model Problem Based Learning (PBL) di kelas VIII SMP Plus Sunan Drajat Jember pada mata pelajaran IPS kompetensi dasar mengidentifikasi bentuk pasar dalam kegiatan ekonomi masyarakat semester genap tahun ajaran 2018/2019. Penelitian ini merupakan penelitian tindakan kelas yang dilakukan selama 2 siklus, setiap siklus terdiri dari 4 tahap yaitu tahap perencanaan, pelaksanaan tindakan, observasi dan refleksi. Subjek penelitian berjumlah 28 siswa. Metode pengumpulan data yang digunakan yaitu metode observasi, tes, wawancara dan dokumen. Penelitian ini menggunakan analisis data deskriptif kualitatif. Hasil penelitian menunjukkan bahwa minat belajar siswa pada siklus I mendapatkan kategori  sedang dengan skor rata-rata sebesar 2,67 meningkat menjadi kategori tinggi pada siklus II dengan skor rata-rata 3,62. Peningkatan hasil belajar siswa dapat dilihat dari nilai rata-rata siswa pada siklus I yaitu 78,03 dengan ketuntasan klasikal 71,42% menjadi 86,42 dengan ketuntasan klasikal sebesar 92,86% pada siklus II.
EFEKTIVITAS PENERAPAN MOBILE APPLICATION “KAI ACCESS” OLEH KONSUMEN DI PT. KERETA API INDONESIA PERSERO DAERAH OPERASI 9 STASIUN JEMBER
Authors: Ayu Wangi Diantini Ni Putu , Sukidin Sukidin , Hartanto Wiwin
Published: April 2020

Suatu perusahaan akan berupaya meningkatkan kualitas pelayanan untuk masyarakat. Salah satu perusahaan yang sudah mengembangkan beberapa inovasi yaitu PT. Kereta Api Indonesia (Persero) dengan menciptakan mobile application “KAI Access” yaitu aplikasi yang digunakan untuk membeli tiket secara online tanpa harus mengantri diloket stasiun. Oleh karena itu tujuan penelitian ini adalah untuk mengetahui efektivitas penerapan mobile application “KAI Access” di Stasiun Jember yang mengacu pada 6 (enam) aspek penilaian yaitu kualitas sistem, kualitas informasi, kualitas pelayanan, penggunaan, kepuasan pengguna, manfaat bersih. Penelitian ini merupakan penelitian deskriptif kuantitatif bertujuan untuk mengetahui nilai variabel mandiri yaitu efektivitas penerapan mobile application “KAI Access” tanpa membuat suatu perbandingan atau menghubungkan dengan variabel lain. Populasi dalam penelitian ini yaitu seluruh penumpang kereta api yang menggunakan mobile application “KAI Access” di Stasiun Jember yang terdiri dri 87 responden. Metode pengumpulan data yang digunakan adalah kuesioner, wawancara dan observasi.

Hasil penelitian menunjukkan bahwa efektivitas penerapan mobile application “KAI Access” oleh konsumen di PT. Kereta Api Indonesia (Persero) Daerah Operasi 9 Stasiun Jember dapat dikatakan sangat efektif. Hal ini dapat dilihat dari penilaian setiap sub variabel efektivitas yaitu kualitas sistem sebesar 85,28%, kualitas informasi sebesar 81%, kualitas pelayanan sebesar 80,85%, penggunaan sebesar 86%, kepuasan pengguna sebesar 82%, manfaat bersih sebesar 80,25%. Berdasarkan persentase nilai responden tersebut maka efektivitas penerapan mobile application “KAI Access” oleh konsumen di PT. Kereta Api Indonesia (Persero) Daerah Operasi 9 Stasiun Jember dinyatakan sangat efektif dimana termasuk dalam rentan nilai diatas 80%.
PENGARUH PENGALAMAN KERJA TERHADAP VOLUME PRODUKSI USAHA BATU BATA DI DESA SONOPATIK KABUPATEN NGANJUK
Authors: Sasongko Bhakti Dimas , Wahyuni Sri , Kartini Titin
Published: April 2020

Penelitian ini brtujuan untuk mengetahui pengaruh yang signifikan pengalaman kerja terhadap volume produksi. Adapun penentuan lokasi penelitian menggunakan metode purposive area yaitu di Desa Sonopatik Kabupaten Nganjuk,  sedangkan pengambilan sampel dilakukan dengan menggunakan metode Qouta Sampling dengan jumlah responden 80 pengrajin. Hasil penelitian menunjukkan bahwa pengalaman kerja memiliki pengaruh yang signifikan terhadap volume produksi usaha batu bata di Dea Sonopatik Kabupaten Nganjuk. Hasil Uji F menunjukkan Fhitung = 323,820 > Ftabel = 3,963 dengan tingkat signifikansi 0,000 < a = 0,05 dengan persamaan regresi sederhana Ŷ = 489.756 + 156.319X. Hasil perhitungan koefisien determinasi (R2) sebesar 0,806, hal ini menunjukkan bahwa besarnya persentase pengaruh Pengalaman kerja memiliki pengaruh yang signifikan terhadap volume produksi usaha batu bata di Dea Sonopatik Kabupaten Nganjuk sebesar 80,6%, sedangkan sisanya yakni 19,4% dipengaruhi oleh variabel bebas lain yang tidak diteliti dalam penelitian ini.
INOVASI PRODUK KUE DALAM MEMPERTAHANKAN SIKLUS HIDUP PADA PERUSAHAAN AMANDA BROWNIES
Authors: Mashita Nadya Cahya Umi , Widodo Joko , Zulianto Mukhamad
Published: April 2020

Penelitian ini bertujuan untuk mendeskripsikan inovasi produk kue dalam mempertahankan siklus hidup pada perusahaan Amanda Brownies. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif. Subjek dalam penelitian ini adalah manager kantor Amanda Brownies cabang Jember, sedangkan informan penelitian yaitu karyawan dan konsumen Amanda Brownies cabang Jember. Metode pengumpulan data yang digunakan yaitu metode wawancara, observasi dan dokumentasi. Metode Analisis data yang digunakan yaitu tahap reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa perusahaan Amanda Brownies melakukan inovasi produk kue dalam mempertahankan siklus hidup produknya. Inovasi produk yang dilakukan perusahaan Amanda Brownies yaitu inovasi berbasis modulasi, inovasi berbasis kemasan, inovasi berbasis desain dan inovasi berbasis pengembangan bahan komplementer. Dengan adanya inovasi produk kue yang dilakukan perusahaan Amanda Brownies mampu mempertahankan siklus hidup produknya sehingga perusahaan Amanda Brownies sampai saat ini masih berada pada tahap pertumbuhan dan tetap bertahan sampai saat ini dengan wilayah pemasaran yang semakin luas hampir di seluruh kota di Indonesia seperti Jember, Situbondo, dan Lumajang meskipun saat ini banyak perusahaan pesaing yang memproduksi produk sejenis.
ANALISIS KONSEPTUAL TEORETIK PENDIDIKAN KEWIRAUSAHAAN SEBAGAI SOLUSI DAMPAK ERA INDUSTRI 4.0 DI INDONESIA
Authors: Sumarno Sumarno , Gimin Gimin
Published: April 2020

This article aims to find out entrepreneurial education as a solution to the impact of the industrial era 4.0 (E.I.4.0). The data were collected by documentation techniques and observation, and then analyzed using descriptive exploratory techniques. The results indicate that E.I.4.0 had a negative impact is the loss of various jobs, but on the other hand had a positive impact, that are the emergence of business and employment opportunities. In E.I.4.0, human resources are required to have the ability to create, innovate, think critically, and collaborate and self-confidence. Entrepreneurship education provides knowledge and skills and develops attitudes that can be a solution to the impact of E.I 4.0. Entrepreneurial knowledge, skills and attitudes will shape human beings in accordance with E.I.4.0, which were the ability to create, innovate, think critically, collaborate, and be confident.  This ability will be able to reach opportunities that arise in order to replace lost jobs. At the level of pre-school education, basic education and general secondary education (SMA/MA), entrepreneurship education should be emphasized more on developing entrepreneurial attitudes and knowledge. At the level of vocational secondary education (SMK/MAK) and higher education, entrepreneurship education should be emphasized more on the development of entrepreneurial skills. Effective implementation of entrepreneurship education for E.I.4.0 requires synergy and integration between subjects or subjects, teachers / lecturers, education levels, and among various stakeholders in a sustainable.

 

Keywords: Industrial era 4.0, entrepreneurship, entrepreneurship education.
PENGGUNAAN MEDIA PREZI UNTUK MENINGKATKAN MOTIVASI DAN HASIL BELAJAR SISWA PADA MATERI JURNAL PENYESUAIAN PERUSAHAAN DAGANG (Studi Kasus Pada Kelas XII IPS 2 SMA Negeri 4 Jember Tahun Ajaran 2018/2019)
Authors: Widyastuti Diah , Kartini Titin , Kantun Sri
Published: April 2020

Penelitian ini bertujuan untuk mendeskripsikan penggunaan media Prezi dalam meningkatkan motivasi dan hasil belajar siswa kelas XII IPS 2 SMA Negeri 4 Jember pada materi jurnal penyesuaian perusahaan dagang semester genap tahun ajaran 2018/2019. Penelitian ini adalah Penelitian Tindakan Kelas (PTK) yang dilakukan sebanyak 2 siklus  mulai dari tahap perencanaan, pelaksaan tindakan, observasi, dan refleksi. Subjek penelitian berjumlah 36 siswa kelas XII IPS 2 SMA Negeri 4 Jember. Metode pengumpulan data menggunakan metode observasi, tes, wawancara, dan dokumen. Analisis data yang digunakan secara deskriptif dengan pendekatan kualitatif. Hasil penelitian menunjukkan bahwa penggunaan media Prezi dapat meningkatkan motivasi dan hasil belajar siswa. Pada siklus I motivasi belajar siswa termasuk dalam kategori sedang dengan skor 1,2 dan mengalami peningkatan pada siklus II dengan skor 1,8 dalam kategori tinggi. Hasil belajar siswa pada siklus I sebesar 79,06 dengan ketuntasan klasikal sebesar 77,7% dan mengalami peningkatan menjadi 82,5 dengan ketuntasan klasikal sebesar 88,8% pada siklus II.
ANALISIS LOYALITAS MEREK LAPTOP ASUS DENGAN NET PROMOTERS SCORE (Studi Kasus pada Mahasiswa Fakultas Ilmu Komputer Program Studi Sistem Informasi Angkatan 2016 Universitas Jember)
Authors: Puspitaningtias Riang , Widodo Joko , Zulianto Mukhamad
Published: April 2020

Penelitian ini bertujuan untuk menganalisis tingkat loyalitas merek asus pada laptop mahasiswa Program Studi Sistem Informasi angkatan 2016 Universitas Jermber dengan menggunakan Net Promoter Score. Subjek penelitian berjumlah 35 mahasiswa Program studi Sistem Informasi Angkatan 2016 Universitas Jember. Metode pengumpulan data menggunakan metode wawancara. Analisis data yang digunakan secara deskriptif dengan pendekatan kualitatif. Hasil penelitian menunjukkan mahasiswa Sistem Informasi angkatan 2016 Universitas Jember loyal terhadap merek laptop Asus. Pada penelitian 22 mahasiswa dari 35 mahasiswa termasuk kedalam kategori promoter dan hanya 6 mahasiswa yang termasuk kedalam kategori Detractor. Hasil Net Promoter Score dari tingkat loyalitas mahasiswa sistem informasi adalah 46.
ANALISIS EFISIENSI PENGGUNAAN MODAL KERJA PADA KOPERASI KARYAWAN SEKAR JEMBER TAHUN BUKU 2015-2017
Authors: Ilhamidya Dessy Nur , Kantun Sri , Kartini Titin
Published: April 2020

Penelitian ini bertujuan untuk menganalisis efisiensi penggunaan modal kerja pada Koperasi Karyawan Sekar Jember tahun buku 2015-2017. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif. Metode pengumpulan data yang digunakan yaitu dokumen dan wawancara. Metode analisis data yang digunakan yaitu analisis rasio efisiensi. Hasil penelitian menunjukkan bahwa tingkat perputaran modal kerja tahun 2015-2017 mengalami kenaikan dan penurunan, yaitu tahun 2015 sebanyak 1,27 kali, tahun 2016 sebanyak 1,03 kali dan 2017 berputar sebanyak 1,04 per tahun dengan kategori kurang efisien. Hasil rentabilitas modal kerjanya mengalami kenaikan setiap tahunnya, yaitu tahun 2015 sebesar 12,80%, tahun 2016 sebesar 13,75% dan tahun 2017 sebesar 16,25% dengan kategori sangat efisien.
PEMAKNAAN BRAND AWARENESS TAS ELIZABETH SEBAGAI BENTUK IDENTITAS DAN KOMUNIKASI GAYA HIDUP SOSIAL (STUDI KASUS MAHASISWI PENDIDIKAN EKONOMI, FAKULTAS KEGURUAN DAN ILMU PENDIDIKAN, UNIVERSITAS JEMBER)
Authors: Jumaiyah Karimatul , Suharso Pudjo , Hartanto Wiwin
Published: April 2020

Kini penampilan menjadi faktor utama dalam menilai status sosial seseorang. Hal yang menyebabkan masyarakat lebih konsumtif karena mereka akan memperbarui penampilan menurut budaya populer dilingkungannya. Budaya populer dilingkungan mahasiswi Pendidikan Ekonomi menggunakan tas Elizabeth, dengan menggunakan tas Elizabeth mahasiswi terlihat lebih percaya diri. Penelitian ini bertujuan untuk mendeskripsikan pemaknaan brand awareness tas Elizabeth sebagai bentuk identitas dan komunikasi gaya hidup sosial (studi kasus mahasiswi Pendidikan Ekonomi, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Jember). Jenis penelitian yang digunakan dalam penelitian ini yaitu penelitian deskriptif dengan pendekatan kualitatif. Metode pengumpulan data menggunakan metode wawancara, metode observasi dan metode dokumentasi. Tahap analisis data, penelitian ini menggunakan reduksi data, penyajian data dan pengambilan kesimpulan. Hasil dari penelitian ini yaitu perbedaan pandangan mahasiswi Pendidikan Ekonomi terhadap tas Elizabeth. Mereka menggunakan tas Elizabeth sebagai penilaian status sosial setiap mahasiswi karena tas Elizabeth memiliki brand image yang baik dilingkungan mahasiswi Pendidikan Ekonomi. Bukan hanya dari brand image, mahasiswi menyadari keunggulan lain yang dimiliki oleh tas Elizabeth. Tas Elizabeth dinilai memiliki kualitas yang baik, model tasnya up to date, memiliki berbagai macam bentuk yang lucu dan tidak mudah rusak. Kesadaran konsumen tentang keunggulan tas Elizabeth inilah menjadi hal terpenting karena tas Elizabeth akan tetap diingat oleh para konsumennya dari segi keunggulan yang dimiliki.
PEMASARAN RELASIONAL PADA TOKO IJEN DESA CINDOGO, KECAMATAN TAPEN, KABUPAEN BONDOWOSO.
Authors: Rizkianingsih Wira , Widodo Joko , Wahyuni Sri
Published: April 2020

Penelitian ini bertujuan untuk mendeskripsikan pemasaran relasional untuk mempertahankan konsumen pada Toko Ijen Desa Cindogo Kecamatan Tapen Kabupaten Bondowoso. Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif. Subjek dalam penelitian ini adalah pemilik toko Ijen, sedangkan informan penelitian yaitu konsumen dari toko ijen. Metode pengumpulan data yang digunakan yaitu observasi, wawancara dan dokumentasi. Analisis data yang digunakan yaitu reduksi data, penyajian data dan verifikasi data. Hasil penelitian ini menunjukkan bahwa Pemasaran Relasional pada Toko Ijen Desa Cindogo Kecamatan Tapen Kabupaten Bondowoso memiliki empat aspek dalam Pemasaran Relasional. Pemasaran Relasional yang dilakukan oleh toko Ijen yang Pertama adalah ikatan, Ikatan yang dilakukan oleh pemilik toko kepada konsumen, memberikan jika konsumen mau berhutang. Kedua kepedulian, kepedulian yang diberikan pemilik toko, Menginformasikan jauh-jauh hari jika toko tidak buka. Ketiga Hubungan Jangka Panjang, hubungan yang diberikan kepada konsumen, mengadakan tasyakuran bersama dengan konsumen. Keempat kepercayaan yang diberikan adalah,  memberikan barang yang masa kadaluarsanya masih lama. dengan adanya keempat elemen tersebut membuat konsumen akan semakin loyal dengan barang yang diual di tempat tersebut. Dengan adanya pemasaran relasional yang dilakukan oleh pemilik toko Ijen mampu mempertahankan pelanggan sehingga toko Ijen mampu bertahan ditengah persaingan dengan toko-toko lain meskipun banyak yang menjual barang sejenis.
Stereo Foto Yorumlama Teknikleri İle Toprak Etüd ve Haritalama Çalışmalarında Multispektral Verilerin Katkısı
Authors: ESETLİLİ Mustafa Tolga , KURUCU Yusuf , ÖZDEN Nejat , ŞANLI Füsun Balık , ÖZEN Fulsen , BOLCA Mustafa
Published: April 2020

Amaç: Araştırmada stereo foto yorum yöntemiyle yapılan toprak etüd ve haritalama çalışmaları sürecinde, çok bantlı uydu görüntülerinden de yararlanma olanağının sağlanması ve bu kazanımın toprak etüd ve haritalama çalışmalarına yapacağı katkı düzeyinin araştırılması amaçlanmıştır.Materyal ve Metot: Çalışma, iki ana bölümden oluşmaktır. Birinci bölümde, geleneksel toprak etüd ve haritalama çalışmaları, ikinci bölümde ise gerçekleştirilen seri bazındaki etüd çalışmalarına birleştirilmiş uydu görüntülerinin katkısının araştırılması şeklinde gerçekleştirilmiştir.Bulgular: Bu araştırma ile çalışma alanı içerisinde kalan topraklar seri bazında tanımlanmış, haritalanmış ve toprak sınıflandırma sistemlerine göre taksonomik sınıfının da belirlenmesiyle birlikte toprak etüd ve haritalama çalışmaları tamamlanmıştır. Bu amaçla, toprakların morfolojik özellikleri yanı sıra laboratuvarda belirlenen ve toprak sınıflandırmada kriter olarak kullanılan fiziksel ve kimyasal analizleri de yapılmıştır. Toprakların sınıflandırması, uluslararası platformlarda kabul görmüş ve günümüzde ülkemizde de kullanılmakta olan Toprak Taksonomisi sınıflandırma sistemi kullanılarak gerçekleştirilmiştir.Çalışmanın ikinci bölümünü oluşturulan uydu görüntülerinin hava fotoğraflarıyla birleştirilmesinden sonra spektral açıdan zenginleştirilmiş görüntü ve bunun toprak etüd ve haritalama çalışmalarına olan katkıları araştırılmıştır. Spektral açıdan zayıf kalan hava fotoğraflarının, birleştirme tekniği (fusion) uygulaması sonucunda uydu görüntülerinden kazanılan spektral zenginlik ile foto yorumlama aşamasında sınır belirleme doğruluk oranını artırabilecek önemli özellikler kazandığı saptanmıştır.Sonuç: Bu araştırma ile stereo ortamda toprak haritası amaçlı yorum yapma çalışmalarında çok bantlı görüntüleme tekniğinin sağladığı verilerin katkısı araştırılmıştır. Araştırmada stereo hava fotoğrafları ile WW2 uydu görüntülerinden sağlanan kızılötesi başta olmak üzere çok bantlı veriler “Fuse” tekniği ile birleştirilmiş, oluşturulan yeni stereo görüntü ile toprak haritası oluşturma amaçlı yorumlama örneklenmiştir.
FilterNet: A Many-to-Many Deep Learning Architecture for Time Series Classification
Authors: Chambers Robert D. , Yoder Nathanael C.
Published: April 2020

We present and benchmark FilterNet, a flexible deep learning architecture for time series classification tasks, such as activity recognition via multichannel sensor data. It adapts popular CNN and CNN-LSTM motifs which have excelled in activity recognition benchmarks, implementing them in a many-to-many architecture to markedly improve frame-by-frame accuracy, event segmentation accuracy, model size, and computational efficiency. We propose several model variants, evaluate them alongside other published models using the Opportunity benchmark dataset, demonstrate the effect of model ensembling and of altering key parameters, and quantify the quality of the models’ segmentation of discrete events. We also offer recommendations for use and suggest potential model extensions. FilterNet advances the state of the art in all measured accuracy and speed metrics on the benchmarked dataset, and it can be extensively customized for other applications.
An Approach to Screen COVID-19 Patients: With Special Reference to Pakistan
Authors: Durrani Faiza , Zaheer Farhat
Published: April 2020

The World Health Organisation declared Covid-19 as a pandemic on 11th March 2020. The main approach to tackle Covid-19 worldwide is to screen and provide supportive care to patients. For screening purpose RT-qPCR based test are used as an initial detections assay. The test is expensive, time consuming and not suitable for mass scale screening/ confirmation requirement. A recent advancement is development of Immunoassay procedures (liquid Phase tests or bed side 10-20minute strip test). In order to help and accelerate bringing life to normal after lock down, Pakistan is in dire need to develop and adopt the immunoassay procedures for mass scale screening and confirmation of COVID-19 infection. It is cheap and easy to perform without a lab requirement.
Chinese Guidelines Related to Novel Coronavirus Pneumonia
Authors: Qiu Tingting , Liang Shuyao , Dabbous Monique , Wang Yitong , Han Ru , Toumi Mondher
Published: April 2020

Background and Objective: China has managed to control the coronavirus disease (COVID-19) with confinement measurements and treatment strategies, while other countries are struggling to contain the spread. This study discusses the guidelines related to COVID-19 in China in order to provide important references for other countries in the fight against COVID-19. Methods: Chinese guidelines relevant to COVID-19 were systematically searched via the China National Knowledge Infrastructure database, YiMaiTong database, and World Health Organization (WHO) COVID-19 database on March 20th, 2020. Guideline information was extracted, including date of publication, source, objectives and the target population. Guidelines specific to the pharmacological treatment of COVID-19 were further investigated to identify the types of antivirus drugs recommended and to report on how treatment recommendations for COVID-19 have evolved overtime. Results: A total of 114 guidelines were identified, of which 87 were national guidelines and 27 were regional guidelines. The scope of included guidelines consisted of: the diagnosis and treatment of COVID-19, the management of hospital departments and specific diseases during the outbreak of COVID-19. Sixty-four of the included guidelines targeted all COVID-19 patients, while the remaining guidelines concentrated on special patient populations (i.e., geriatric population, pediatric population, and pregnant population) or patients with coexisting diseases. Twenty-three guidelines focused on the pharmacological treatments for all COVID-19 patients. Interferon, Lopinavir/Ritonavir, Ribavirin, Chloroquine, and Umifenovir represented the most recommended antivirus drugs. With the emergence of encouraging results from preclinical and preliminary clinical studies, Chloroquine Phosphate was recommended in the national Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (6th version) on February 19th, 2020. Thereafter, more detailed guidelines regarding the adjustment of dosage regimens and the monitoring of adverse events of Chloroquine Phosphate were published. To date, 8 Chinese guidelines have recommended Chloroquine Phosphate or Hydroxychloroquine as mainstream antivirus drug for the treatment of COVID-19. Conclusions: China has generated a plethora of guidelines covering almost all aspects of COVID-19. Chloroquine, as one widely affordable treatment, holds great potential to become the gold standard choice as more clinical evidence is shared by researchers from China as well as other countries.
Development of a Field-deployable RT-qPCR Workflow for COVID-19 Detection
Authors: Nyaruaba Raphael , Zhang Bo , Muema Caroline , Muturi Elishiba , Oyejobi Greater , Xiong Jin , Li Bei , Shi Zhengli , Mwaliko Caroline , Yu Junping , Li Xiaohong , Wei Hongping
Published: April 2020

Outbreaks of coronavirus disease 2019 (COVID-19) have been recorded in different countries across the globe. The virus is highly contagious, hence early detection, isolation, and quarantine of infected patients will play an important role in containing the viral spread. Diagnosis in a mobile lab can aid to find infected patients in time. Here, we develop a field-deployable diagnostic workflow that can reliably detect COVID-19. Instruments used in this workflow could easily fit in a mobile cabin hospital and also be installed in the community. Different steps from sample inactivation to detection were optimized to find the fastest steps and portable instruments in detection of COVID-19. Each step was compared to that of the normal laboratory diagnosis set-up. From the results, our proposed workflow (80 min) was two times faster compared to that of the normal laboratory workflow (183 min) and a maximum of 32 samples could be detected at each run. Additionally, we showed that using 1% Rewocid WK-30 could inactivate the novel coronavirus directly without affecting the overall detection results. Comparison of our workflow using an in-house assay to that of a commercially acquired assay produced highly reliable results. From the 250 hospital samples tested, there was a high concordance 247/250 (98.8%) between the two assays. The in-house assay sensitivity and specificity were 116/116 (100%) and 131/134 (97.8%) compared to that of the commercial assay. Based on these results, we believe that our workflow is fast, reliable, adaptable and most importantly, field deployable.
The Shadow of M87* Black Hole within Rational Nonlinear Electrodynamics
Authors: Kruglov Sergey
Published: April 2020

We consider rational nonlinear electrodynamics coupled to General Relativity. The effective geometry induced by nonlinear electrodynamics corrections are found. We determine shadows of regular non-rotating magnetic black holes and compare them with the shadow of the super-massive M87* black hole imaged by the Event Horizon Telescope collaboration. This allows us to obtain the black hole magnetic charge. The size of the shadow is very close to the shadow of non-regular neutral Schwarzschild black holes. As a result, we can interpret the super-massive M87* black hole as a regular (without singularities) magnetized black hole.
Epigenetic Regulation Mediated by miRNA in the Susceptibility and Pathogenesis of Rheumatoid Arthritis
Authors: Guo Shicheng , Chang Cen , Xu Lingxia , Zhang Runrun , Jin Yehua , Xiong Momiao , He Dongyi
Published: April 2020

micro-RNA (miRNA) has been demonstrated to play important roles in the transcriptome regulation and disease development including cancer and autoimmune disease such as rheumatoid arthritis. However, a comprehensive map on how the mRNAs regulate transcripts, pathways, immune system differentiation and interaction with terminal cells like T-cells, fibroblast-like synoviocytes (FLS), osteoblast and osteoclast still unknown. In this review, we have provided a thorough summary on the roles of miRNAs in the susceptibility, pathogenesis, diagnosis, therapeutic intervention and prognosis. Numerous miRNAs were found abnormally expressed in rheumatoid arthritis relevant cells and regulated the target genes and pathways like NF-κB, Fas-FasL, JAK-STAT, IRE1-RIDD, mTOR pathway. In addition, miRNA act as gene expression regulators affect the T-cell differentiate to different cell types including Th17 and T-reg cells which provide promising gene therapy target to regulate immune systems in rheumatoid arthritis. We also summarized interesting diagnosis and prognosis roles of blood and cell-free based miRNAs which provided novel opportunity to work together with rheumatoid factors (RF), anti-CCP to provide accurate diagnosis and prognosis especially for seronegative patients. Furthermore, functional genetic variants in miRNA-499 and miRNA-146a explained part of missing susceptibility of rheumatoid arthritis. Finally, miRNAs were showed as promising biomarker to indicate the DMRDS and immunotherapy efficiency, drug response and resistance. What’s more, autotherapeutic effect of miRNA intervention provided promising to develop miRNA based rheumatoid arthritis drugs. Overall, current evidence supports miRNAs as the interesting targets to better understand the pathogenetic mechanism and therapeutic intervention of rheumatoid arthritis.
Dengue Epidemic Is a Global Recurrent Crisis: Review of the Literature
Authors: Araf Yusha , Ullah Md. Asad , Faruqui Nairita Ahsan , Mowna Sadrina Afrin , Prium Durdana Hossain , Sarkar Bishajit
Published: April 2020

Purpose: This review highlights the global scenario of dengue outbreaks, dengue pathogenesis, symptoms, immune response, diagnosis methods and preventive measures which facilitates the better understanding of the global expansion and concerns relating to the disease. Recent Findings: A recent study showed that natural killer cells of the infected person become activated soon after the infection which may help in treatment and vaccine development. A research team has also produced synthetically engineered mosquitoes that can prevent the transmission and dissemination of the dengue virus by the activation of an antibody. Furthermore, a mutation in the protein envelope of the dengue virus leads to variation in shapes, developing resistance towards the vaccine. Summary: The mosquito vectors marked their worldwide distribution through an increasing number of reported cases which was further facilitated by the growth in the shipping and commerce industries. The immune system, through activation of the innate and adaptive immune responses, facilitates the recruitment of an array of leukocytes which help neutralize the virus. Apart from the laboratory standard PRNT method, several other dengue detection methods such as ELISA, RT-LAMP and several optical, microfluidic and electrochemical methods have been developed. The existence of the 4 different viral serotypes makes the secondary infection life-threatening and also leads to difficulties in vaccine development. Since Dengvaxia® (CYD-TDV) has its own set of drawbacks and limitations, several companies have been investing for the production of more potential vaccines that are currently in trial.
Periacetabular Osteotomy for Developmental Dysplasia of the Hip and Femoroacetabular Impingement
Authors: Holleyman Richard , Sohatee Mark Andrew , Witt Johan , Bankes Marcus J.K. , Andrade Tony J. , Board Tim , Lee Conroy Jonathan , Wilson Matthew , McBryde Callum , Khanduja Vikas , Malviya Ajay
Published: April 2020

Background:

Periacetabular osteotomy (PAO) is a well-recognized procedure for the treatment of hip dysplasia in young adults and can be used for the surgical management of femoroacetabular impingement (FAI) with acetabular retroversion. The aim of this study was to use a national database to assess the outcomes of PAO for developmental dysplasia of the hip (DDH) and for FAI.

Methods:

All patients in whom an isolated PAO had been performed between January 2012 and February 2019 were identified in the Non-Arthroplasty Hip Registry (NAHR). Their outcomes were assessed using the EuroQol-5 Dimensions (EQ-5D) index and the International Hip Outcome Tool (iHOT)-12 preoperatively and then at 6 months, 12 months, and 2 years postoperatively.

Results:

Six hundred and thirty (630) PAOs were identified, with 558 (89%) performed for DDH and 72 (11%) performed for FAI. Most patients (90%) were female. The mean age in the DDH group (31.2 years) was significantly higher (p < 0.0001) than that in the FAI group (26.5 years). There were no other significant between-group demographic differences. Preoperatively and at each follow-up time-period, iHOT-12 scores were better in the DDH group than in the FAI group; however, only the preoperative scores differed significantly. There was significant improvement between the preoperative and 6-month iHOT-12 and EQ-5D index scores in both the DDH and the FAI group. This improvement was maintained at 12 months postoperatively, by which time almost 90% of the patients had achieved the minimum clinically important difference (MCID) in their iHOT-12 score.

Conclusions:

This study shows that PAO is a successful surgical intervention for DDH and FAI in the short term, with significant improvement in patient-reported outcome scores that is maintained up to 2 years postoperatively.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
MAXIMUM SUSTAINABLE YIELD OF TRAWL FISHERY ALONG THE SOUTH-WEST COAST OF INDIA: BAYESIAN ESTIMATION APPROACH
Authors: Sathianandan T. V. , Kuriakose Somy , Mini K. G. , Safeena P. K.
Published: April 2020

The south-west region of the Indian coast is shared by three maritime states and it contributes nearly 32% to the total marine fish production of the country. Mechanised trawl fishery accounts for 44% of the marine fish harvest in the south-west coast and a number of resources are harvested by trawl nets from this region. An assessment of the trawl fishery to determine sustainable harvest levels for mechanised trawlers in the region was carried out using time series data on annual landings and fishing effort of mechanised trawlers during the period 1990-2015. A Bayesian estimation method for Schaefer model was used for the analysis. Posterior probability densities of parameters of the model, maximum sustainable yield (MSY) and corresponding biomass were obtained through Bayesian estimation for the trawl fishery in south-west coast and the harvest levels were found to be above MSY from 2012 onwards. Forecasts of biomass and fish landings by mechanised trawlers upto 2025 under different levels of fishing effort were also simulated using the model to study the dynamic changes over time. It was found that the numbers of multiday trawlers and single day trawlers operating in this region have to be reduced by 207 and 36 respectively to retain the harvest at sustainable level.
EFFECT OF POLYPHENOLS SUPPLEMENTED CANOLA MEAL BASED DIET ON GROWTH PERFORMANCE, NUTRIENT DIGESTIBILITY AND ANTIOXIDANT ACTIVITY OF COMMON CARP (CYPRINUS CARPIO LINNAEUS, 1758) FINGERLINGS
Authors: Hussain Syed Makhdoom , Gohar Hina , Razul Azhar , Shahzad Muhammad Mudassar , Akram Afia Muhammad , Tariq Muhammad , Hussain Majid , Ali Mukthar , Khhalid Anam
Published: April 2020

A 70-days feeding trial was conducted to assess the impact of polyphenols supplemented canola meal based diets on growth performance, nutrient digestibility and antioxidant activity of common carp (Cyprinus carpio Linnaeus, 1758) fingerlings. Seven experimental diets viz., T0, T1, T2, T3, T4, T5, T6 and T7 with graded levels of polyphenols at 0, 100, 200, 300, 400, 500 and 600 mg kg-1 respectively were formulated. Each treatment diet was fed to fishes in triplicate tanks and in each replicate, fifteen fingerlings were stocked. Effect of each treatment on the weight gain, feed conversion ratio (FCR), specific growth rate (SGR), nutrient digestibility and antioxidant activity were assessed. Maximum growth performance, highest SGR (1.41) and best FCR (1.31) was observed in fish fed test diet T4 having 400 mg kg-1 of polyphenols. Nutrient digestibility in terms of crude protein (72%), crude fat (76%) and gross energy (67%) also significantly increased (p<0.05) by supplementation of polyphenols at 400 mg kg-1 level. With respect to antioxidant activity, increasing trend was observed with increasing levels of dietary polyphenols with the highest antioxidant activity recorded in fish fed T6 diet supplemented with 600 mg kg-1 of polyphenols.
IN SILICO CHARACTERISATION AND HOMOLOGY MODELLING OF TOLL/TOLL LIKE RECEPTORS (TLRS) FROM PENAEID SHRIMPS
Authors: Angela Mercy A. , Hemamalini N. , Aruljothi K. , Chrisolite B. , Karalmarx K.
Published: April 2020

Toll or Toll-like receptors are conserved receptors, which act as the first line of defense against infection by pathogens. To use Toll/Toll like receptors as drug targets, it is essential to understand their physico-chemical properties and three dimensional structures. In the present study, physico-chemical properties and secondary structure of Toll/Toll like receptors from selected species of penaeid shrimps viz., Penaeus chinensis, P. vannamei, P. monodon and P. japonicus were computed using online servers. Three dimensional structure was predicted by homology modelling using different softwares, SWISS-MODEL, Phyre2 and Geno3D softwares were validated using online tools to find the best model for the protein under study. From the physicochemical properties, nature of the Toll/Toll like receptor protein was revealed as acidic, thermostable, hydrophobic and transmembrane protein. Structural analysis indicated the presence of alpha helices and random coils as predominant elements followed by extended stands and beta turns. Three dimensional structures predicted using SWISS-MODEL was validated as extremely good model using Protein Quality Predictor online server.
EVALUATION OF DIETARY SUPPLEMENTATION OF L-LYSINE AND PHYTASE IN CORN GLUTEN MEAL-SOYBEAN MEAL BASED DIETS FOR PACIFIC WHITE SHRIMP PENAEUS VANNAMEI (BOONE, 1931)
Authors: Manikandan K. , Felix N.
Published: April 2020

An eight-weeks feeding trial was conducted to study the effects of dietary L-lysine and/or phytase supplementation in corn gluten meal-soybean meal (CGM-SBM) protein blend diets on the growth, apparent digestibility, whole body chemical composition and digestive enzyme activity of Pacific white shrimp Penaeus vannamei (Boone, 1931) juveniles. Five isonitrogenous and isolipidic diets were formulated viz., control diet (T0), with 20% fishmeal was compared against four CGM-SBM based diets, T1 with no supplementation, T2 supplemented with L-lysine, T3 supplemented with phytase and T4 supplemented with L-lysine + phytase. Dietary lysine supplementation had a significant effect (p<0.05) on growth performance and feed conversion ratio (FCR), while supplementation of dietary phytase had no effect on growth performance. Apparent digestibility coefficient (ADC) value for crude protein increased by 2.5 to 3% on supplementation of phytase (500 FTU kg-1 feed) in the diets. The protein digestibility increased by 8 to 11% with the addition of dietary phytase than other treatment groups with no supplementation of phytase. The amylase and lipase enzyme activity of T3 and T4 supplemented with dietary phytase was higher than the groups that were not supplemented with dietary phytase. Higher protease activity was observed in T2 diet supplemented with dietary L-lysine. L-lysine and phytase supplementation in plant based CGM-SBM protein blend diets resulted in better growth performance of P. vannamei.
Affordances and Constraints of Implementing Lesson Study for Teachers’ Professional Development: A Review
Authors: KIHWELE JIMMY
Published: April 2020

Lesson Study (LS) has been adopted worldwide as a research tool for teachers who teach the same subjects to cooperate in identifying problems, planning a lesson, teaching that lesson and coming up with solutions to the problem identified. This helps them grow professionally. This study is a review of approaches to implementing LS in different places, of opportunities that the use of LS provides, and of constraints on its effectiveness and sustainability. In this study, 30 published research articles were thoroughly studied and analyzed so as to answer three key questions that serve as its underpinning. The findings show that the methods used to implement LS vary in many places. However, in several cases, LS practitioners try to implement the original structure of LS as it was implemented in Japan in the 1960s. The findings show that LS affords more pedagogical opportunities than constraint: teachers learn new professional skills and knowledge and they improve their understanding of the subject matter and change their attitudes, beliefs and views on collaborative working.
Professionalism, Leadership Style, Understanding of Governance and Role of Supervision in Affecting Auditor Performance
Authors: Salman Kautsar Riza , Hatta Devi Saidul
Published: April 2020

Auditors’ performance in general is the result of an objective audit assignment towards the financial statements of a company or other organization in order to determine whether the financial statements have been fairly presented in accordance with generally accepted accounting principles. This study aims to determine the effect of professionalism, leadership style, understanding of governance, and the role of supervision of auditor performance. This study uses a questionnaire filled out by BPKP government auditors in East Java Province. Data analysis from this study uses multiple linear regression test using SPSS 23 program. This study found that only professionalism influences auditor performance. This result implies the importance of professionalism of the auditors because it can affect performance. The results of the study also imply that external factors such as leadership style, understanding of governance, and the role of supervision are not important factors in influencing auditor performance.
Analysing Iraqi Railways Network by Applying Specific Criteria Using the GIS Techniques
Authors: Et al. Naji
Published: April 2020

The railways network is one of the huge infrastructure projects. Therefore, dealing with these projects such as analyzing and developing should be done using appropriate tools, i.e. GIS tools. Because, traditional methods will consume resources, time, money and the results maybe not accurate. In this research, the train stations in all of Iraq’s provinces were studied and analyzed using network analysis, which is one of the most powerful techniques within GIS. A free trial copy of ArcGIS®10.2 software was used in this research in order to achieve the aim of this study. The analysis of current train stations has been done depending on the road network, because people used roads to reach those train stations. The data layers for this study were collected and prepared to meet the requirements of network analyses within GIS. In this study, the current train stations in Iraq were analyzed and studied depending on accessibility value for those stations.  Also, to know the numbers of people who can reach those stations within a walking time of 20 minutes. So, this study aims to analyze the current train stations according to multiple criteria by using network analysis in order to find the serviced areas around those stations. Results will be presented as digital maps layers with their attribute tables that show the beneficiaries from those train stations and serviced areas around those stations depending on specific criteria, with a view to determine the size of this problem and to support the decision makers in case of locating new train stations within the best locations for it.
Correlation Between Ischemia-Modified Albumin Level and Coronary Collateral Circulation
Authors: Chen Xin , Lin Yan , Tian Lihua , Wang Zhiquan
Published: April 2020

Objective: To investigate the correlation between ischemia-modified albumin (IMA) levels and coronary collateral circulation (CCC) in patients with chronic total occlusive (CTO). Methods: Coronary angiography was performed in the Department of Cardiology, Zhongnan Hospital of Wuhan University from 2017-08 to 2019-02 to identify 128 patients with CTO lesions in at least one major coronary artery. According to the Rentrop evaluation criteria, the degree of CCC formation was divided into the poor CCC formation group (Rentrop0-1 grade,n=69) and the good CCC formation group(Rentrop2-3 grade,n=59). The IMA level of the patients was measured using an albumin-cobalt binding assay. The general data, routine blood panel, total bilirubin (TBIL), blood lipids, uric acid (UA), left ventricular ejection fraction (LVEF) and other indicators of the patients were recorded and analyzed while assessing the patients' blood vessel occlusion. Results: The proportion of platelet count and diabetes in the poor CCC group was higher than that in the good CCC group (P<0.05). The ratio of ischemia-modified albumin and total bilirubin in the poor CCC group was lower than that in the good CCC group (P<0.05). Multivariate logistic regression analysis showed that ischemia-modified albumin was positively correlated with CCC formation [OR=1.190,95% CI(1.092-1.297),P<0.001], while diabetes was negatively correlated with CCC formation [OR=0.285,95% CI(0.094-0.864),P<0.05]. Ischemic modified albumin predicted good formation of CCC according to the ROC curve, and the area under the ROC curve was 0.769(95% CI:0.686-0.851，P＜0.001); the optimal cut-off value was 63.35 KU/L, and the sensitivity was 71.2%,specificity is 71%. Conclusion: The IMA level is closely related to good formation of CCC. Higher IMA levels can be used as an effective predictor of good CCC formation in patients with CTO.
Impact of the Ebola virus disease outbreak (2014-2016) on Tuberculosis Surveillance Activities in Guinea's National Tuberculosis Program: A Time Series Analysis
Authors: Magassouba Aboubacar Sidiki , Diallo Boubacar Djelo , Camara Lansana Mady , Sow Kadiatou , Camara Souleymane , Bah Boubacar , Barry Alpha Oumar , Diallo Thierno Hassane , Aboubacar Camara , Bangoura Adama Marie , Sow Oumou Younoussa
Published: April 2020

Background: Most countries in Subsaharan Africa have well-established National Tuberculosis Control Programs with relatively stable routine performances. However, major epidemiological events may result in significant disruptions. In March 2014, the World Health Organization announced the outbreak of Ebola virus disease in Guinea, a country with a high incidence of TB and HIV. Our study aims to assess the impact of the Ebola virus disease outbreak on TB notification, treatment and surveillance, using main indicators.Methods: This is a retrospective cohort study that compares TB trends using surveillance data from the periods before (2011-2013), during (2014-2016) and after (2017-2018) Ebola virus disease outbreak. A time series analysis is conducted to investigate the linkages between the decline in TB notification and the Ebola virus disease outbreak through cross-correlation. The lag in the cross-correlation test is evaluated using ANCOVA type II delayed variable dependent model. The surveillance system is assessed using TB surveillance standards and benchmarks and vital registration systems recommended by WHO, compared with those of 2015 during the Ebola virus disease.Results: The rate of reporting of TB declined from 120 cases per 100,000 in 2011 to 100 cases per 100,000 in 2014, at the peak of the Ebola virus disease outbreak. The time series cross-correlation test of all notified cases of TB and Ebola shows a significant lag of -0.4 (40%), reflecting a drop in the rate of notification (F-value=5.7 [95% CI: 0.2-21.3]). However, the Ebola virus disease had no negative impact on patient treatment outcomes (F-value=1.3 [95% CI: 0.002-8.8179]). Regarding the surveillance system, five out of 13 WHO standards and benchmarks were met following their evaluation in 2019, after the Ebola virus disease outbreak, compared to three in 2015.Conclusion: Major epidemics such as the Ebola virus disease outbreak may have a significant impact on well-established TB control programs as shown in the example of Guinea. On the other hand, it is noticed that, sudden disruptions of routine performance may lead programs to improve their surveillance system.