bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacogenetic Testing and Therapeutic Drug Monitoring Of Sertraline at a Residential Treatment Center for Children and Adolescents: A Pilot Study
Authors: France Katelyn , Ammend David , Brown Jacob
Published: December 2022

Background: Sertraline is commonly prescribed to children for the treatment of anxiety and major depressive disorder and is metabolized in part by CYP2C19. While dosing recommendations based on CYP2C19 genotype exist, there is sparse data in children on the relationship between sertraline concentrations and CYP2C19 genotype. Additionally, although rarely utilized in the United States, therapeutic drug monitoring can also help to guide dosing. The primary objective of this pilot study was to compare sertraline concentrations with CYP2C19 genotype. Secondary objectives included exploring the feasibility of using pharmacogenetic testing and therapeutic drug monitoring in a residential treatment center for children and adolescents.
Methods: This study was a prospective, open-label study of children prescribed sertraline being treated at a residential treatment center for children and adolescents. Individuals were included if they were < 18 years of age, taking sertraline for at least 2 weeks allowing them to reach steady-state concentrations, being treated through the residential treatment program, and able to understand and speak English.
Results: A total of 20 participants (80% female) completed all study procedures, including pharmacogenetic testing and therapeutic drug monitoring, with an average age of 15.4 years (range: 9-17 years). Forty percent (n=8) of participants had a diagnosis of Generalized Anxiety Disorder, while 30% (n=6) had a diagnosis of Major Depressive Disorder. Overall, average sertraline and desmethylsertraline concentrations were 21.1 ng/ml (range: 1-78 ng/ml) and 52.4 ng/ml (range: 1-258 n/ml). Based on CYP2C19 genotypes, 60% (n=12) were normal metabolizers, 10% (n=2) were intermediate metabolizers, and 30% (n=6) were rapid metabolizers. Daily sertraline dose (mg/day) accounted for a significant amount of the observed variability in sertraline (p<0.0001; r2=0.62) and desmethylsertraline concentrations (p<0.001; r2=0.45). When comparing weight-based dosing by sertraline and desmethylsertraline concentrations, sertraline daily dose by weight (mg/kg/day) also accounted for a significant amount of the observed variability in sertraline (p<0.0001; r2=0.60) and desmethylsertraline (p<0.0001; r2=0.59) concentrations. Average daily and weight-based doses for CYP2C19 intermediate, normal, and rapid metabolizers were 75 mg/day, 87.5 mg/day, and 79.2 mg/day and 1.5 mg/kg/day, 1.3 mg/kg/day, and 1.1 mg/kg/day, though these were not significantly different.
Conclusion: This small, pilot study showed sertraline dose to be significantly associated with sertraline and desmethylsertraline concentrations. No differences were noted between CYP2C19 metabolizer groups, likely due to the limited sample size. These results also suggest that ordering pharmacogenetic testing and therapeutic drug monitoring in the setting of a child and adolescent residential treatment center is feasible.
Rasch Measurement and Patient Reported Value Claims: A Primer for Hemophilia
Authors: Langley Paul C
Published: December 2022

This commentary proposes that Rasch Measurement Theory (RMT) is an innovative method for assessments of patient-centric therapy response in hemophilia A and B, as they are in other disease states or target patient populations. RMT is a necessary and sufficient approach to moving from ordinal observations to interval measurement, which has arithmetic properties. This applies across the board in hemophilia and other disease states for clinical value claims, patient centric or subjective value claims as well as those for anticipated drug utilization and other medical care resources. The purpose of this commentary is to point out limitations regarding current methods for making claims regarding hemophilia response and to propose a new start in hemophilia studies to identify core claims that meet required measurement standards. This applies to both the development of new patient reported outcome instruments as well as the evaluation of existing instruments, with a focus on polytomous instruments and their sub-domains, to evaluate their possible application as measures that approximate RMT requirements.
Applied Machine Learning Algorithms and Landsat 8 for Estimating Aboveground Carbon Stock in Evergreen Broadleaf Forest in Binh Phuoc Province
Authors: Thanh Tuan Nguyen , Phu Nguyen Van , Quy Nguyen Van , Nhung Hoang Thi Phuong
Published: December 2022

Abstract: The assessment of carbon stocks is one of the key measurements to support climate change mitigation policies. The research applied Landsat 8 satellite imagery combined with field-measurements using four machine learning methods (random forest - RF, artificial neural networks - NNET, support vector machines – SVM, and linear regression - LM) to estimate aboveground carbon in evergreen broadleaf forest in Binh Phuoc province. The field sample plots were randomly divided into training (96 plots) and testing (24 plots) data. The results showed that RF yielded the greatest precision with an R2 value above 0,9 and RMSE below 6 ton/ha on the training data, with an R2 value of 0,41 and RMSE of 11,04 ton/ha on the testing data. The estimate of forest carbon stock increased distinctly from the mean value of 59,80 ton/ha in the very poor forest to 87,78 ton/ha in the rich forest. The results found in the present study demonstrated that Landsat 8 imagery in conjunction with RF has the appropriate to estimate aboveground carbon stock in evergreen broadleaf forest-leaved in Binh Phuoc province.

Keywords: Random forest, aboveground carbon, REDD+, forest carbon estimation.
Acute aortic occlusion leading to spinal cord ischemia in a 73-year-old: A case report
Authors: Taghlabi Khaled M. , Bhenderu Lokeshwar S. , Guerrero Jaime R. , Sulhan Suraj , Jenson Amanda V. , Cruz-Garza Jesus G. , Faraji Amir H.
Published: December 2022

Background:

Cauda equina syndrome (CES) is typically caused by a compressive etiology from a herniated disk, tumor, or fracture of the spine compressing the thecal sac. Here, we report a CES mimic – acute aortic occlusion (AAO), a rare disease that is associated with high morbidity and mortality. AAO can compromise spinal cord blood supply and leads to spinal cord ischemia.

Case Description:

Our patient presented with an acute onset of bilateral lower extremity pain and weakness with bowel/bladder incontinence, a constellation of symptoms concerning for CES. However, on initial imaging, there was no compression of his thecal sac to explain his symptomology. Further, investigation revealed an AAO. The patient underwent an emergent aortic thrombectomy with resolution of symptoms.

Conclusion:

AAO can mimic CES and should be considered in one’s differential diagnosis when imaging is negative for any spinal compressive etiologies.
Botulinum Toksinin Gummy Smile Tedavisinde Kullanımı
Authors: Gürbüz Ezgi , Kaçar Zeki
Published: December 2022

Clostridium botulinum adlı bakteri tarafından üretilen botulinum toksininin terapötik etkisi, kolinerjik nöron sinapslarında asetilkolin salınımını bloke etmesinden ve kas kontraksiyonuna engel olmasından kaynaklanmaktadır. Terapötik amacın yanı sıra kozmetik amaçla da uygulanan botulinum toksininin kullanımı oftalmoloji, gastroenteroloji, üroloji, ortopedi ve dermatoloji gibi birçok medikal alana yayılmıştır. Baş ve boyun bölgesinde trigeminal nevralji, migren, larenjektomi sonrası özofageal konuşma, fasiyal sinir paralizi, siyalore, temporomandibular eklem bozuklukları, bruksizm, çiğneme kaslarında miyalji ve hemifasiyal spazm gibi birçok durumda terapötik amaçla kullanılmaktadır. Botulinum toksini aynı zamanda gummy smile, gülme asimetrisi, unilateral masseter hipertrofisine bağlı gelişen fasiyal asimetri gibi perioral kozmetik uygulamalarda da başarıyla kullanılmaktadır. Hiperaktif dudak kaslarının neden olduğu gummy smile tedavisinde botulinum toksini enjeksiyonu, uygulama kolaylığı ve güvenliği açısından minimal invaziv bir yaklaşım olarak tercih edilmektedir. Bu geleneksel derlemede, elektronik ortamda kaynak taraması yapılarak botulinum toksininin gummy smile tedavisinde kullanımına dair elde edilen güncel bilgiler yer almaktadır.
Graph neural networks for prediction of protein isoelectric points
Authors: Brenner Tom
Published: December 2022

Graph neural networks were used to model protein isoelectric points. Predictions contained markedly fewer outliers (predicted with errors > 0.5 pH units) compared to tools published in the literature, despite slightly higher root-mean-squared errors. This result was reproduced for graph convolutional and graph isomorphism networks when node features used only one-hot encoding of amino acid sequences. Graph isomorphism networks could also produce similar predictive powers when employing physical descriptors of the amino acids, either alone or in addition to the one-hot encoded features.
An Analytical Platform for Near Real-Time Drug Landscape Monitoring using Paraphernalia Residues
Authors: Appley Meghan G , Robinson Elizabeth L , Thomson Allison , Russell Erin , Sisco Edward
Published: December 2022

Deaths attributed to drug overdoses are constantly on the rise, but drug trends are frequently changing and often differ across geographical regions. Current analytical techniques are limited in their abilities to rapidly identify drugs that would inform both public health and law enforcement officials about the evolving drug landscape. The work presented here outlines an analytical platform that utilizes ambient ionization mass spectrometry and additional techniques (e.g., tandem mass spectrometry) to qualitatively analyze trace residues from drug paraphernalia to quickly detect both drugs and cutting agents. To demonstrate proof-of-concept, samples collected from syringe service programs throughout the state of Maryland were analyzed by direct analysis in real time – mass spectrometry (DART-MS) to provide rapid, near complete chemical profiles (drugs, cutting agents, and other compounds of interest). To obtain a more complete chemical profile, it was found that a small subset of samples (7.5 %) benefited from additional analysis by either direct analysis in real time – tandem mass spectrometry (DART-MS/MS) or liquid chromatography – tandem mass spectrometry (LC-MS/MS). This additional analysis enabled confirmation of the presence or absence of questioned compounds, assisted in identification of new compounds, and provided isomer differentiation without hindering the rapid reporting of results. This analytical platform utilizing DART-MS and, where necessary, tandem mass spectrometry techniques, was found to detect a wide range of drugs and cutting agents in a manner that can better inform public health and public safety personnel about the drug landscape in “near real-time”.
Process-informed adsorbent design guidelines for direct air capture
Authors: Young John , Mcilwaine Fergus , Smit Berend , Garcia Susana , van der Spek Mijndert
Published: December 2022

Direct air capture using solid adsorbents is a proven technology critical to reducing our net greenhouse gas emissions to zero and beyond. Currently, academic research into the technology mainly focuses on the development of new adsorbents. However, there is a discord between the adsorbent design and process performance. Many materials scientists focus on maximising metrics such as the CO2 capacity of their adsorbent. Here, we combine detailed process modelling, machine learning, and extensive global sensitivity analysis, which entails varying all of the model parameters together, on a direct air capture process to show that the dry CO2 adsorption capacity does not influence process performance for an amine-functionalised adsorbent operating in a temperature vacuum swing adsorption (TVSA) process, while it is important in a steam-assisted TVSA (S-TVSA) process. In fact, adsorption kinetics, density, and thermal conductivity are all critical attributes to obtaining a low energy penalty and reduced costs. The analysis also highlights the importance of heat transfer, directing process engineers to (alternative) adsorber designs that maximise this. By an in-depth evaluation of how process performance indicators are affected by materials properties and process operating parameters, this work provides guidance to both material scientists and process engineers towards the design of a "unicorn adsorbent" and intensified DAC processes. This will improve the performance of solid adsorbent direct air capture and help drive down the costs of this vital technology to avert the worst impacts of climate change.
A biomimetic approach to promote cellular uptake and enhance photoacoustic properties of tumor-seeking dyes
Authors: East Amanda , Lee Michael , Jiang Chang , Sikander Qasim , Chan Jefferson
Published: December 2022

The attachment of glucose to drugs and imaging agents enables cancer cell targeting via interactions with GLUT1 overexpressed on the cell surface. While an added benefit of this modification is the remarkable solubilizing effect of carbohydrates, in the context of imaging agents, aqueous solubility does not guarantee decreased π-stacking or aggregation. The resulting broadening of the absorbance spectrum is a detriment to photoacoustic (PA) imaging since the signal intensity, accuracy, and image quality all rely on reliable spectral unmixing. To address this major limitation and further enhance the tumor-targeting ability of imaging agents, we have taken a biomimetic approach to design a multivalent glucose moiety (mvGlu). We show-case the utility of this new group by developing aza-BODIPY-based contrast agents boasting a significant PA signal enhancement greater than 11-fold after spectral unmixing. Moreover, when applied to targeting cancer cells, effective staining could be achieved with ultra-low dye concentrations (50 nM) and compared to a non-targeted analog, the signal intensity was >1000-fold higher. Lastly, we employed the mvGlu technology to develop a logic-gated acoustogenic probe to detect intratumoral Cu(I), which is an emerging cancer biomarker, in a murine model of breast tumor. This was exciting application not possible using other acoustogenic probes previously developed for copper sensing.
The winning team reached the terra incognita: Enantioselective synthesis of ferrocene 1,3-derivatives via distal C-H activation by Pd(II)/norbornene cooperative catalysis
Authors: Gupta Princi , Tiwari Prakash Chandra , Madhavan Suchithra , Kapur Manmohan
Published: December 2022

Together they solved the cold case! Activation of the distal C-H bonds of ferrocene and its stereoselective functionalization is not a dream anymore. Here we report, regio-and stereo selective catalytic distal C-H functionalization of ferrocenes actualizing the synthesis of ferrocene-1,3-derivatives by a Catellani-type reaction. The winning Pd/norbornene catalyst combination is able to reach hitherto inaccessible reaction site of ferrocene and accomplishes the regio-and stereoselective arylation of ferrocenylmethylamine. The ligand controlled synergistic Pd/norbornene metal-organic cooperative catalysis under aerobic conditions successfully achieves the synthesis of 30 ferrocene-1,3 derivatives in moderate to good yields and with high enantioselectivity in the substrates scanned.
GAS-SENSITIVE COMPOSITE NANOSTRUCTURES BASED ON ZINC OXIDE FOR DETECTING ORGANIC SOLVENT VAPORS
Authors: Налимова Светлана Сергеевна , Шомахов Замир Валериевич , Герасимова Ксения Валерьевна , Пунегова Ксения Николаевна , Гукетлов Аслан Мухамедович , Калмыков Рустам Мухамедович
Published: December 2022

В работе показаны возможности применения композитных структур ZnO-Fe в качестве газочувствительных слоев для детектирования паров органических растворителей на примере изопропилового спирта. Композитные структуры получены на основе наностержней оксида цинка, синтезированных гидротермальным методом, за счет изменения их состава при выдержке в растворе сульфата железа. Исследование химического состава поверхности проводили с помощью рентгеновской фотоэлектронной спектроскопии. Показано, что при использовании раствора сульфата железа с концентрацией 0,025 моль/л на поверхности наблюдаются атомы железа и цинка. Повышение концентрации раствора до 0,05 моль/л приводит к осаждению частиц оксида железа на поверхность слоя наностержней. Исследование газочувствительных характеристик проводили при температуре 250°С при воздействии паров изопропилового спирта в диапазоне концентраций от 200 до 1000 млн. Установлено, что величина отклика композитных структур ZnO-Fe (0,025) превышает соответствующее значение для наностержней оксида цинка, что может быть обусловлено большим содержанием кислородных вакансий в композитном образце.

The paper shows the possibilities of using ZnO-Fe composite structures as gas-sensitive layers for detecting organic solvent vapors exemplifying on isopropyl alcohol. Composite structures were formed based on zinc oxide nanorods synthesized by the hydrothermal method, due to changes in their composition in a ferrous sulfate solution. The chemical composition of the surface was studied using X-ray photoelectron spectroscopy. It is shown that when using a ferrous sulfate solution with a concentration of 0,025 mol/l, iron and zinc atoms are observed on the surface. An increase in the concentration of the solution to 0,05 mol/l leads to the deposition of iron oxide particles on the surface of the nanorods. The study of some gas-sensitive characteristics was carried out at 250°C when exposed to isopropyl alcohol vapors in the concentration range from 200 to 1000 ppm. It was found that the response value of composite structures ZnO-Fe (0,025) exceeds the corresponding value for the zinc oxide nanorods, that may be due to the high content of oxygen vacancies in the composite sample.
Modelo de asignación y co-localización de actividades marítimas para el ordenamiento marino-costero en el departamento de Bolívar, Colombia
Authors: Afanador Franco Fernando , Molina Jiménez Maria Paula , Pusquin Ospina Lady Tatiana , González Bustillo María José , Banda Lepesqueur Carlos , Berrío Reyes Yerlis Paola , Escobar Olaya Germán Augusto , Castro Mercado Iván
Published: December 2022

La tendencia al crecimiento del sector marítimo debido al aumento en la población, al desarrollo urbanístico y a la industrialización, han generado la diversificación de usos en las zonas marino-costeras causando conflictos por la relación uso/espacio. Por esto la Dirección General Marítima Colombiana (Dimar), ha desarrollado una metodología que permite analizar las condiciones futuras para el desarrollo de actividades marítimas en las aguas y costas colombianas, a través del Ordenamiento Marino Costero: Visión de Autoridad Marítima (OMC:VAM), que en su proceso metodológico plantea el Modelo de Asignación y Co-localización (MAYC), el cual busca establecer la localización espacial de las áreas más adecuadas para actividades marítimas, teniendo en cuenta criterios técnicos, ambientales y variables de eficiencia/eficacia establecidos por la DIMAR, tipo de actividad marítima, disponibilidad y cobertura de la información. El modelo se aplicó en la zona marino-costera del departamento de Bolívar, encontrando, con base en los criterios seleccionados para las diferentes actividades, que un 90 % del área es apta para llevar a cabo actividades de acuicultura, un 84 % es apta para instalación de parques eólicos y un 0.39 % de área es adecuado para construcción de marinas-embarcaderos.
CONTROLE DA APLICAÇÃO DO PADRÃO DECISÓRIO: TÉCNICA DA DISTINGUISHING
Authors: Murta Antônio Carlos Diniz , Saraiva Carmen Ferreira , Campos Marcelo Barroso Lima Brito de
Published: December 2022

Este artigo versa sobre a teoria dos precedentes judiciais estadunidense de referencial obrigatório dos fatos e sua adaptação ao modelo brasileiro de fixação de tese jurídica vinculativa pautada na razão de decidir. Os julgados que direcionam a solução de controvérsias posteriores são parâmetros utilizados na verificação da distinção entre a questão a ser solucionada no caso concreto e a tese impositiva, pretérita, genérica e abstrata. Na investigação adota-se pesquisa bibliográfica, por meio do método dedutivo e comparativo, com foco na tendência de universalização de ideias e de uniformização jurisprudencial do Supremo Tribunal Federal.
O ZONEAMENTO ECOLÓGICO ECONÔMICO COMO INSTRUMENTO DE PLANEJAMENTO DE POLÍTICAS PÚBLICAS MUNICIPAIS: UM ESTUDO SOB A PERSPECTIVA DO CICLO DE POLÍTICAS PÚBLICAS
Authors: De Freitas Reis Vilela Ribeiro Patrícia , Junqueira Ribeiro José Cláudio
Published: December 2022

O artigo trata do Zoneamento Ecológico Econômico como instrumento para o planejamento municipal, a partir da abordagem do Ciclo de Políticas Públicas. A pesquisa foi realizada pelo método qualitativo, dogmático, descritivo e hipotético-dedutivo. Evidenciou-se haver norma vinculante de sua utilização na elaboração do Plano Diretor. Concluiu-se que o ZEE consiste em instrumento de formulação de políticas públicas, ante seu potencial para fornecer diagnósticos de questões a serem tratadas pelo Poder Público, e diretrizes para organização territorial e desenvolvimento socioeconômico sustentável, inclusive, para solução de controvérsias nas tomadas de decisão.
VIOLÊNCIA SEXUAL INFANTIL: UMA COMPARAÇÃO ENTRE A POLÍTICA PÚBLICA DE ENFRENTAMENTO DO BRASIL E DA NORUEGA
Authors: De almeida Vanessa therezinha sousa , Hogemann Edna Raquel Rodrigues Santos , Oliveira Arianne Albuquerque de Lima
Published: December 2022

Analisa as semelhanças e diferenças entre Brasil e Noruega no enfrentamento da violência sexual infantil, em especial, no que se refere à colheita das declarações da vítima, que deve servir tanto para a proteção dela como para a punição do ofensor concomitantemente. Discorre sobre os modelos do Barnahus e dos Centros Integrados, mas também tece considerações sobre a atuação descentralizada em caso de inexistência dos Centros. Recorre a uma base teórica de inspiração funcionalista e universalista. Classifica-se a pesquisa como exploratória, qualitativa, com recursos bibliográficos e método dialético, trazendo discussões sobre contribuições possíveis para os dois países.
INTERPRETAÇÃO DAS NORMAS PELAS LENTES DA PERSPECTIVA DE GÊNERO SEGUNDO TEORIA DE JUSTIÇA DE NANCY FRASER
Authors: Barroso Carolina Pyles , Tavares Neto Jose Querino
Published: December 2022

O presente trabalho tem como escopo contribuir epistemologicamente com o Poder Judiciário na análise do Direito em uma perspectiva de gênero e na efetivação do direito das mulheres ao acesso à justiça, pois embora exista grande arcabouço normativo, os direitos fundamentais e sociais no que tange as relações de gênero, permanecem, desassistidos. Será realizada revisão de literatura, de caráter exploratório, sobre direito fundamental de igualdade de gênero, com especial atenção sobre a mulher no mercado de trabalho, ao modelo da teoria de justiça de Nancy Fraser, expondo sobre o direito à igualdade de gênero por meio da norma constitucional.
TRABALHO INFANTIL NO MEIO AMBIENTE DO TRABALHO RURAL, RISCOS E DANOS À SAÚDE DE CRIANÇAS E ADOLESCENTES E POSSÍVEIS MEDIDAS AO SEU ENFRENTAMENTO
Authors: Franco Dulcely Silva , De Almeida Silva Samara Tavares Agapto das Neves , Padilha Norma Sueli
Published: December 2022

O trabalho infantil rural expõe crianças e adolescentes a condições perversaspróprias do trabalho no campo, prejudicando-lhes a saúde e o desenvolvimento. Este artigoobjetiva descrever os riscos e danos sofridos por esses sujeitos no meio ambiente do trabalhorural. O método utilizado é o hipotético-dedutivo, as técnicas de pesquisa são a bibliográfica ea documental. Conclui-se que o trabalho infantil rural precisa ser combatido e, para tanto, faz-se necessário maior fiscalização do Poder Público, desenvolvimento de políticas públicascapazes de implementar as legislações que protegem as crianças e adolescentes desse tipo deatividade e estudos acadêmicos a respeito.
СТРОЕНИЕ И ТЕРМОДИНАМИЧЕСКИЕ ХАРАКТЕРИСТИКИ ПРОМЕЖУТОЧНЫХ КАТАЛИТИЧЕСКИХ АДДУКТОВ В ОКИСЛЕНИИ КУМОЛА В ПРИСУТСТВИИ 2-ЭТИЛГЕКСАНОАТА МЕТАЛЛА 2-ОЙ ГРУППЫ
Authors: Улитин Н.В. , Анисимова В.И. , Хурсан C.Л. , Балдинов А.А. , Суворова И.А. , Нуруллина Н.М. , Шиян Д.А. , Терещенко К.А. , Бадртдинова А.И. , Денисова М.Н. , Харлампиди Х.Э. , Гржегоржевский К.В. , Абрамов П.А.
Published: December 2022

Экспериментально исследована кинетика окисления кумола в присутствии 2-этилгексаноата Mg, Ca, Sr, Ba, при этом обнаружено, что лучшим катализатором с точки зрения активности является 2-этилгексаноат Mg. Методом PBEPBE-GD3/def2TZVP показано, что промежуточные аддукты кумола, гидропероксида кумола (гош- и транс- конформеры) и диметилфенилкарбинола с 2-этилгексаноатом Mg термодинамически возможны. На основе квантово-химических расчетов (PBEPBE-GD3/def2TZVP) получены данные о строении промежуточных аддуктов и распределении электронной плотности. По совокупности структурных, энергетических параметров аддуктов, характера распределения электронной плотности, прочности связи О–О установлено, что промежуточный аддукт гидропероксида кумола (транс-конформер) с 2-этилгексаноатом Mg наиболее быстро распадается на свободные радикалы. По результатам квантово-химического моделирования предложен механизм каталитического действия 2-этилгексаноата Mg в окислении кумола.
Молекулярно-динамическое моделирование деформационного поведения композита графен/Al
Authors: Сафина Л.Р. , Рожнова Е.А.
Published: December 2022

В работе представлены результаты моделирования методом молекулярной динамики деформационного поведения композита графен/Al. Рассмотрены и подобраны параметры потенциала Морзе для описания взаимодействия в системе графен/Al. Показано, что выдержка при комнатной температуре с последующим гидростатическим сжатием при 300 К и 600 К позволяет получать прочные композитные материалы. В работе получено, что максимальный предел прочности имеет композит графен/Al, сформированной при 600 К, который также демонстрирует высокую пластичность. Показано, что за счет слабой энергии связи между графеном и Al в процессе деформационной обработки наночастицы Al стремятся коагулировать. Наличие наночастиц алюминия с одной стороны повышает пластичность композита, но с другой стороны именно на наночастицах происходит его дальнейшее разрушение. Полученные результаты способствуют лучшему понимаю процессов формирования композитов на основе скомканного графена и наночастиц Al.
Outcomes of post-exposure vaccination by modified vaccinia Ankara to prevent mpox (formerly monkeypox): a retrospective observational study in Lyon, France, June to August 2022
Authors: Merad Yanis , Gaymard Alexandre , Cotte Laurent , Perpoint Thomas , Alfaiate Dulce , Godinot Matthieu , Becker Agathe , Cannesson Olivier , Batalla Anne-Sophie , Oria-Yassir Fatima , Landré Sophie , Morfin Florence , Bouscambert Maude , Valour Florent , Ader Florence , Conrad Anne
Published: December 2022

Modified vaccinia virus Ankara vaccine (MVA-BN; Bavarian Nordic) is recommended to contacts of mpox cases up to 14 days post-exposure but the effectiveness of this strategy is unknown. Among 108 adults (≥ 18 years old) who received one dose of MVA-BN after exposure to mpox, 11 (10%) cases of breakthrough mpox were observed. Sexual exposure was associated with the risk of breakthrough mpox (p = 0.0179). Samples taken from vaccinated breakthrough mpox cases had similar rates of infectious virus isolation than unvaccinated mpox cases.
Multidrug-resistant organisms in patients from Ukraine in the Netherlands, March to August 2022
Authors: Zwittink Romy D , Wielders Cornelia CH , Notermans Daan W , Verkaik Nelianne J , Schoffelen Annelot F , Witteveen Sandra , Ganesh Varisha A , de Haan Angela , Bos Jeroen , Bakker Jacinta , Schneeberger-van der Linden Caroline , Kuijper Ed J , de Greeff Sabine C , Hendrickx Antoni PA ,   on behalf of the Dutch CPE and MRSA Surveillance Study Groups
Published: December 2022

Since March 2022, there has been an emergence of multidrug-resistant organisms (MDRO) in the Netherlands in patients originating from Ukraine (58 patients, 75 isolates). For about half of these patients, recent hospitalisation in Ukraine was reported. Genomic surveillance revealed that the majority of the MDRO represent globally spread epidemic lineages and that 60% contain New Delhi metallo-β-lactamase (NDM) genes. Professionals should be aware of an increase in such MDRO associated with migration and medical evacuation of people from Ukraine.
Increase in NDM-1 and NDM-1/OXA-48-producing Klebsiella pneumoniae in Germany associated with the war in Ukraine, 2022
Authors: Sandfort Mirco , Hans Jörg B , Fischer Martin A , Reichert Felix , Cremanns Martina , Eisfeld Jessica , Pfeifer Yvonne , Heck Annika , Eckmanns Tim , Werner Guido , Gatermann Sören , Haller Sebastian , Pfennigwerth Niels
Published: December 2022

In 2022, German surveillance systems observed rapidly increasing numbers of NDM-1- and NDM-1/OXA-48-producing Klebsiella pneumoniae, which may in part reflect recurring pre-pandemic trends. Among these cases, however, a presence in Ukraine before diagnosis was frequently reported. Whole genome sequencing of 200 isolates showed a high prevalence of sequence types ST147, ST307, ST395 and ST23, including clusters corresponding to clonal dissemination and suggesting onward transmission in Germany. Screening and isolation of patients from Ukraine may help avoid onward transmission.
Recubrimiento biodegradable antifúngico a base de quitosano y aceite esencial de cítricos para la conservación de papaya (Carica papaya L.) en poscosecha
Authors: García-Mateos María del Rosario , Corrales-García Joel , Cornejo-Vivar Teresita , Hernández-Ramos Lyzbeth
Published: December 2022

La papaya es una fruta climatérica altamente perecedera. La antracnosis, enfermedad provocada por hongos, es una de las principales causas de pérdida poscosecha. La actividad de extractos vegetales ha permitido la inhibición del desarrollo de microorganismos, en particular se ha reportado la actividad antifúngica de aceites esenciales. El objetivo de la presente investigación fue evaluar el efecto de un recubrimiento biodegradable a base de quitosano con aceite esencial de cítricos, aplicado en etapa poscosecha, en las propiedades físicoquímicas, fisiológicas e inhibición del crecimiento del hongo Colletotrichum gloeosporioides en frutos de papaya (Carica papaya L.). El recubrimiento se preparó con quitosano, glicerol, ácido acético, aceite esencial de Citrus reticulata (0.5 %, 1.0 % y 1.5 %) y Tween® 80. La solución se aplicó con una brocha en la epidermis de los frutos de papaya y se almacenaron a temperatura ambiente (24 °C ± 2 °C) por 10 d, junto con los frutos testigo. Las variables evaluadas en los frutos fueron color, pH, sólidos solubles totales (SST), firmeza, pérdida de peso, producción de CO2, de etileno y daño por antracnosis. Se utilizó un modelo estadístico completamente al azar. Los datos se sometieron al análisis de varianza (ANOVA) y comparación de medias por la prueba de Tukey (P < 0.05). El recubrimiento aplicado retrasó el cambio de color de la epidermis de los frutos de papaya, la pérdida de peso, firmeza y SST respecto a los frutos testigo. Los cambios estuvieron asociados a la modificación de la tasa de respiración y de producción de etileno de los frutos con recubrimiento. La matriz del quitosano conteniendo aceites esenciales, usada como recubrimiento, mejoró significativamente la vida de anaquel de la papaya y disminuyó más del 80 % el daño por antracnosis.
Calidad microbiológica: detección de Aeromonas sp y Pseudomonas sp en garrafones provenientes de pequeñas plantas purificadoras de agua
Authors: Venegas Berenice , Tello-Hernández Marco Antonio , Cepeda-Cornejo Verónica , Molina-Romero Dalia
Published: December 2022

Las plantas purificadoras de agua que carecen de un adecuado sistema de control de calidad pueden generar problemas de salud pública. El objetivo de este estudio fue examinar la calidad microbiológica del agua proveniente de pequeñas plantas purificadoras de la ciudad de Puebla, así como, determinar la existencia de bacterias Aeromonas sp y Pseudomonas sp, y caracterizar si presentan un fenotipo patógeno oportunista. Se recolectaron 70 muestras de garrafones de agua de 25 establecimientos. La cuantificación bacteriana se realizó mediante el método de goteo en placa. Se comprobaron los géneros microbianos mediante análisis bioquímico. En las cepas que mostraron discrepancia se utilizó la identificación molecular con base a secuencias parciales del gen 16S rRNA para confirmar su especie y se les evaluaron sus características de patogenicidad: multirresistencia a antibióticos, producción de biopelícula y actividad hemolítica. El 40 % de las plantas purificadoras no cumplieron con la calidad microbiológica del agua para consumo humano. El 41.4 % de los garrafones de agua muestreados incumplió la normativa, presentando coliformes totales 35.7 %, Pseudomonas 30 %, Enterococcus faecalis 8.6 % y bacterias coliformes fecales el 5.7 %. Se obtuvieron 56 aislados, provenientes de los 29 garrafones contaminados; 10 de ellos se caracterizaron molecularmente, resultando 7 aislados relacionados con especies diferentes de P. aeruginosa y 3 con especies de Aeromonas. De los aislados de Pseudomonas, 5 presentaron resistencia a 2 familias de antibióticos y 2 mostraron multirresistencia. El 36 % de los 10 aislados produjeron hemólisis y biopelícula. Dos cepas de Aeromonas mostraron resistencia a Cefalosporina 3a generación pero no produjeron hemólisis. Los 10 aislados analizados fueron clasificados como no patógenos. Es necesario un seguimiento sanitario más estricto para lograr el cumplimiento de las normas nacionales e internacionales relacionadas con el consumo de agua purificada, para evitar dañar la salud de los consumidores.
Rastgele orman algoritması ve Sentinel-2 MSI ile fındık ekili alanların belirlenmesi: Piraziz Örneği
Authors: TERZİ TÜRK Seda , BALÇIK Filiz
Published: December 2022

Türkiye’de yetiştirilen sert kabuklu meyvelerin başında gelen fındık, özellikle Doğu Karadeniz bölgesi için ekonomik olarak büyük önem taşımaktadır. Bu çalışmada, 22 Ekim, 2020 tarihli Sentinel-2 MSI uydu görüntüsü bantları ve hesaplanan indeksler ile oluşturulan farklı veri setleri kullanılarak fındık ekili tarım alanları belirlenmiştir. Çalışmaya dâhil edilen farklı bitki indekslerinin hesaplanması ile 5 veri seti üretilmiştir. Giresun ili Piraziz ilçesi çalışma bölgesi seçilmiştir. Sınıflandırma işlemi için rastgele orman (RO) görüntü sınıflandırma yöntemi kullanılmıştır. Çalışma alanında 7 farklı Arazi Kullanımı/Arazi Örtüsü (AKAÖ) tipleri tanımlanmıştır. Birinci veri seti için; seçilen Sentinel-2 MSI bantları RO algoritması ile sınıflandırılmıştır. Diğer veri setlerinde sırasıyla; Normalize Edilmiş Fark Bitki Örtüsü İndeksi (NDVI), Yeşil Bant Normalize Edilmiş Fark Bitki Örtüsü İndeksi (GNDVI) ve Normalize Edilmiş Fark Kırmızı Kenar İndeksi (NDVIre) eklenmiştir. 5 veri setine ait sınıflandırma sonuçları hata matrisi kullanılarak karşılaştırılmıştır. McNemar testi sonuçlarına göre her veri seti için sınıflandırma doğruluğu arasındaki farkların istatistiksel olarak anlamlı olmadığı görülmüştür. Veri seti 1 için hesaplanan genel doğruluk %98.98 ve Kappa değeri 0,98 ile diğer dört veri setinden daha yüksek elde edilmiştir.
Novel g.2055A>C and g.2064T>A Polymorphisms of KISS1 Gene and Its Association with Reproductive Traits in Local Indonesian Goats
Authors: FEBRİANA Achiriah , KURNİANTO Edy , BAKAR Abu , SABİR Sabir , PRAMONO Yoyok Budi , SUTOPO Sutopo
Published: December 2022

Kisspeptins are known as neuropeptides encoded by the KISS1 gene, which potentiates GnRH neuron excitability. Unfortunately, the role of the KISS1 gene in reproductive traits remains unclear in Indonesian native goat breeds. The current study purposed to detect the genetic variation of the KISS1 gene and investigate the association with reproductive traits in goats to acquire marker-assisted selection (MAS) for the breeding program. Further, ninety blood samples from randomly selected animals were used for DNA isolation and SNP genotyping. The blood serum was collected from sixteen treated goat does to assess FSH levels using ELISA method. The differences between studied parameters were determined using independent samples T-test from SAS Software. Two SNPs, g.2055A>C (SNP1) and g.2064T>A (SNP2) were discovered in intron 1 of KISS1 gene in Indonesian native goat breeds. Two genotypes were identified from each SNPs: AA and AC at SNP1 and TT and TA at SNP2. The allele A (0.96) at SNP1 and allele T (0.93) at SNP2 were discovered as dominant alleles in the population. Furthermore, chi-square test showed that both SNPs were under Hardy-Weinberg equilibrium. The variants of KISS1 gene have no effect on litter size (p>0.05). Moreover, AA genotype of SNP1 had a higher FSH level than that observed in AC genotype (p<0.0001), especially in the follicular phase. SNP2 does not correlate with FSH level relatively (p=0.23). Furthermore, using of AA genotype at SNP1 of KISS1 gene as MAS for the breeding selection program could escalate the reproductive traits in goats
Cations-Base Application in Rubber Plantation: The Change of Calcium, Magnesium, and Potassium Status in the Soil and Leaves and Its Relation to Latex Yield
Authors: PUTRA Irwan Agusnu , HANUM Hamidah , TISTAMA Radite , PURBA Edison
Published: December 2022

Nutrient balance in the soil support plant growth and yield. The objective of this study was aimed to obtain doses of calcium, magnesium, and potassium fertilizers in relation to the ratio of cations-base (Ca2+, Mg2+, K+) to increase latex yield in rubber plants. The study was conducted on a rubber plantation in Dolok Masihul Sub-district, Serdang Bedagai District, North Sumatra, Indonesia, from January to August 2019. The treatment was used with three factors, including the first factor was CaCO3 (0; 1 500 g/tree/year), the second factor of MgSO4.H2O (0; 1 500; 3 000; 4 500 g/tree/year), and the third factor by KCl (0; 500; 1 000; 1 500 g/tree/year) in a Randomized Block Design (RBD) within three replicates. Results showed that the calcium of 1 500 g/tree/year increased the Mg-latex and latex yield by 160.70 g/tree/tapping. An increase in the three cations-base in soil, leaves, latex, and latex yield was also observed after the application of magnesium ranged by 1 500 to 4 500 g/tree/year. The potassium 500 - 1 500 g/tree/year increased the cations-base in soil, latex, and Ca-leaves. The interaction of calcium 1 500 + magnesium 1 500 - 4 500 and potassium 0-1 500 g/tree/year increased the exchange-K, Mg-latex, and also Mg- and K-leaves. The ratio of Ca:Mg:K in soil, leaves, and latex were 2: 1: 2 (optimum), 5: 1: 11 (high), and 1: 11: 32. The Ca, Mg, K in leaves and K-latex positively correlates and increases latex yield due to the three fertilizations.
The Strategy of Improving the Performance of Cooperatives in the Review of Organizational Culture, Innovation is Mediated by the Entrepreneurial Orientation in Surabaya
Authors: Andjarwati Tri , Budiarti Endah , Setiono Beni Agus
Published: December 2022

Purpose: The aim of research to proved and analyzed strategy to improve cooperative performance through organizational culture, innovation in mediation with entrepreneurship orientation in surabaya city.

Design/methodology/approach: The type of this research was surveying research and the data from questionnaire will be as primer data.

Findings: The results showed that organizational culture positive and significant effect against the entrepreneurial orientation, innovation is a positive and significant effect against the entrepreneurial orientation, organizational culture positive and significant effect performance improvement strategies towards cooperative, positive effect not significant innovation strategy improved performance of cooperatives, entrepreneurial orientation effect positive and significant performance improvement strategies against the cooperative.

Research limitations/implications: The data collected were declared valid and reliable, then processed for analysis using structural equation model or Structural Equation Modeling (SEM).

Practical implications: The population study for this research was all primary cooperatives in Surabaya with total  400 cooperatives that have the following characteristics: (a) has a member of a minimum of 100 people, (b) active of operations and implement RAT for 3 years successively, (c) has more than two business units (d) and has assets of over 1 billion rupiah. The sample for this research was 138 primary cooperation.

Originality/value: This paper is original

Paper type: Literature review
Digital Marketing at SMES by Bibliometric Analisys
Authors: Naldi Syafri , Maulina Erna , Herawaty Tetty
Published: December 2022

Purpose: Digital marketing has evolved from the marketing of products and services to digital channels for activities, institutions, and processes facilitated by digital technology. This study provides a disciplinary broad overview of the academic contribution to the marketing revolution by exploring changes in digital marketing research in SMEs cited by scientific researchers over 19 years (2001-2020). Thus, this paper presents a systematic literature review using bibliometric analysis with the aim of examining development trends, identifying gaps, understanding the advantages and benefits of digital marketing on SMEs and mapping out new hypotheses for future research.

Design/methodology/approach: The method used is a bibliometric study to search for articles related to the research theme

Findings: The results show that social media is the keyword that is often employed. Related research has been achieved in many countries, and the most predominant are England and America.

Research limitations/implications: This study is limited to a single database, Scopus, from 2001 to 2020.

Practical implications: The findings of this study are likely to serve as a starting point for future research in digital marketing.Besides, it becomes a resource to make the most of social media marketing to grow SMEs.

Originality/value: This paper is original.

Paper type: a Research Paper
Who's Publishing Systematic Reviews? An Examination Beyond the Health Sciences
Authors: Slebodnik Maribeth , Pardon Kevin , Hermer Janice
Published: December 2022

The number of systematic reviews (SRs) published continues to grow, and the methodology of evidence synthesis has been adopted in many fields outside of its traditional health sciences origins. SRs are now published in fields as wide ranging as business, environmental science, education, and engineering; however, there is little research looking at the nature and prevalence of non-health sciences systematic reviews (non-HSSRs). In this study, a large sample from the Scopus database was used as the basis for analyzing SRs published outside the health sciences. To map the current state of non-HSSRs, their characteristics were investigated and the subject areas publishing them determined. The results showed that a majority of the non-HSSRs examined were lacking at least one characteristic commonly expected in health sciences systematic review (HSSRs) methodology. The broad subject areas publishing non-HSSRs fall mostly within the social sciences and physical sciences.
Peranan konselor dalam konseling keluarga untuk meningkatkan keharmonisan keluarga
Authors: Putri Julia Eva , Mudjiran Mudjiran , Nirwana Herman , Karneli Yeni
Published: December 2022

Kehidupan berkeluarga merupakan perjalanan yang dibentuk oleh dua insan yang terikat dalam pernikahan. Dalam perjalanan kehidupan tersebut akan selalu ada masalah yang menghampiri baik itu bersumber dari dalam ataupun dari luar diri individu yang menjalaninya. Berbagai permasalahan permasalahan keluarga tersebut dapat di selesaikan melalui konseling keluarga. Konseling keluarga efektif untuk mengatasi masalah dalam keluarga. Konseling keluarga dapat membantu anggota keluarga mendapatkan keharmonisan dalam keluarga karena dalam proses konseling, konseli akan berupaya mengetahui, mengenali, memperhatikan, menerima dan berusaha untuk mempertahankan keluarganya. Konseling keluarga dapat membantu mencegah dan mengatasi masalah dalam keluarga sehingga konseli dapat mempertahankan keharmonisan keluarganya.
Pengembangan Bahan Ajar Leksikon Gender Bermuatan Kearifan Lokal Pada Materi Variasi Bahasa Mata Kuliah Sosiolinguistik
Authors: Jafar Syamsinas , Syahbuddin Syahbuddin , M. Ali Nasaruddin , Aswandikari Aswandikari , Kaharuddin Kaharuddin
Published: December 2022

Penelitian ini merupakan penelitian pengembangan bahan ajar dalam mata kuliah sosiolinguistik pada Program Studi Pendidikan Bahasa dan Sastra Indonessia FKIP Universitas Mataram. Penelitian ini bertujuan (a) merancang bahan ajar leksikon gender bahasa Sasak yang bermuatan nilai kearifan lokal pada materi variasi bahasa mata kuliah sosiolinguistik menjadi produk/model bahan ajar, (b) mengetahui  keefektifan dan kelayakan bahan  ajar leksikon gender bahasa Sasak bermuatan nilai kearifan lokal pada materi variasi bahasa mata kuliah sosiolinguistik digunakan sebagai produk/model bahan ajar. Metode yang digunakan dalam penelitian ini jenis kualitatif berupa penelitian pengembangan R and D (Research and Development) dengan pendekatan model ADDIE. Model ADDIE ini dilaksanakan mengikuti langkah-langkah pengembangan yaitu (1) analisis (analize), (2) disain (design), (3) pengembangan (development), implementasi (implementation), dan evaluasi (evaluation). Penelitian pengembangan ini telah menghasilkan rancangan produk/model bahan ajar leksikon gender bahasa Sasak yang bermuatan kearifan lokal dalam submateri variasi bahasa gender pada mata kuliah sosiolinguistik dengan prosentase sangat baik (93,75) berdasarkan hasil validasi para ahli. Sebagai produk/model, bahan ajar ini telah diimplementasikan dan dievaluasi pada kelas besar mahasiswa pada mata kuliah sosiolinguistik, dengan kategori keefektifan dan kelayakan baik dengan prosentase 74, 4%.   Bahan ajar leksikon gender bahasa Sasak bermuatan kearifan lokal sebagai produk telah dicantumkan dalam RPS mata kuliah sosiolinguistik sebagai submateri pada materi variasi bahasa gender.
Pengaruh Permainan Penyae Terhadap Kemampuan Berhitung Matematika Siswa Kelas II SD Yayasan Hadi Sakti Tahun Ajaran 2022
Authors: Kurnia Dwi Agam , Safruddin Safruddin , Rosyidah Awal Nur Kholifatur
Published: December 2022

Siswa kelas II SD Yayasan Hadi Sakti memiliki kemampuan berhitung yang masih dibawah rata-rata, hal ini dapat dilihat dari hasil belajar siswa yang belum mencapai nilai KKM pada mata pelajaran matematika. KKM pada mata pelajaran matematika di SD Yayasan Hadi Sakti di adalah 75, sedangkan di kelas II mendapat rata-rata nilai yaitu 60. Untuk mengatasi masalah tersebut mata pelajaran matematika dapat dikolaborasikan dengan permainan tradisional, salah satunya adalah permainan penyae. Tujuan dari penelitian ini adalah melihat pengaruh permainan penyae terhadap kemampuan matematika siswa kelas II. Penelitian berlokasi di SD Yayasan Hadi Sakti kelurahan Bertais, kecamatan Sandubaya, kota Mataram. Jenis penelitian yang digunakan adalah penelitian eksperimen, dengan desain one group pretest-posttest (satu kelompok pretest-posttest). Jumlah sampel yang digunakan adalah sebanyak 17 siswa, diantaranya 8 siswa perempuan dan 9 siswa laki-laki. Instrumen yang digunakan dalam penelitian adalah tes kemampuan berhitung, lembar observasi keterlaksanaan pembelajaran dan dokumentasi. Hasil penelitian didapatkan adanya peningkatan rata-rata nilai dalam pretest dan posttest sebesar 26,76, pretest mendapatkan nilai rata-rata 59,71 dan posttest mendapat nilai rata-rata 86,18. Berdasarkan uji hipotesis menggunakan uji paired sample t-test didapatkan nilai signifikasi 0,00 dengan ketentuan jika <0,05 maka ada perbedaaan nilai rata-rata pretest dan posttest. Sehingga kesimpulan dari penelitian adalah permainan penyae berpengaruh terhadap kemampuan berhitung siswa kelas II SD Yayasan Hadi Sakti.