bluuebunny/crossref_metadata_2025 huggingface dataset:
Batteries not included
Authors: Hester Josiah , Sorber Jacob
Published: September 2019

Getting things done amid frequent power failures, batteryless intermittent research is rethinking how we build computing systems and paving the way to a sustainable and scalable digital future. The next trillion devices might be a little weird.
Dual-specificity phosphatase 1 regulates cell cycle progression and apoptosis in cumulus cells by affecting mitochondrial function, oxidative stress, and autophagy
Authors: Fu Xu-huang , Chen Cheng-zhen , Li Sheng , Han Dong-xu , Wang Yi-jie , Yuan Bao , Gao Yan , Zhang Jia-bao , Jiang Hao
Published: September 2019

Dual-specificity phosphatase 1 ( DUSP1) is differentially expressed in cumulus cells of different physiological states, but its specific function and mechanism of action remain unclear. In this study, we explored the effects of DUSP1 expression inhibition on cell cycle progression, proliferation, apoptosis, and lactate and cholesterol levels in cumulus cells and examined reactive oxygen species levels, mitochondrial function, autophagy, and the expression of key cytokine genes. The results showed that inhibition of DUSP1 in cumulus cells caused abnormal cell cycle progression, increased cell proliferation, decreased apoptosis rates, increased cholesterol synthesis and lactic acid content, and increased cell expansion. The main reason for these effects was that inhibition of DUSP1 reduced ROS accumulation, increased glutathione level and mitochondrial membrane potential, and reduced autophagy levels in cells. These results indicate that DUSP1 limits the biological function of bovine cumulus cells under normal physiological conditions and will greatly contribute to further explorations of the physiological functions of cumulus cells and the interactions of the cumulus-oocyte complex.
Stem cell antigen/Ly6a protects against bladder fibrosis in mice
Authors: Tassone Nicholas M. , Li Belinda , Patel Mehul S. , Devine Megan Y. , Firmiss Paula R. , Gould Andrew D. , Kochan Kirsten S. , Stubbee Reid A. , Bowen Diana K. , Dettman Robert W. , Gong Edward M.
Published: September 2019

We have defined a population of stem cell antigen (Sca)-1+/CD34+/lin−mesenchymal stem cells in the mouse urinary bladder. These cells are reduced after partial bladder outlet obstruction (PO). To test the role of Sca-1 expressed by these cells, we analyzed bladders from Sca-1 knockout (KO) mice in both uninjured male mice and male mice subjected to PO. We found that loss of Sca-1 alone had little effect on bladder development or function but reduced the total number of mesenchymal stem cells by 30%. After PO, bladders from Sca-1-null KO male mice were larger, with more collagen and less muscle, than obstructed wild-type mice. Steady-state levels of caldesmon were significantly reduced and levels of fibroblast-specific protein 1 were significantly increased in Sca-1 KO mice compared with wild-type mice after PO. In investigating the effects of PO on cell proliferation, we found that loss of Sca-1 changed the timing of cell division in CD34+/lin−, collagen-producing, and smooth muscle cells. PO in combination with loss of Sca-1 drastically reduced the ability of CD34+/lin−cells to form colonies in vitro. Our findings therefore support the hypothesis that Sca-1 protects the bladder from fibrotic remodeling after obstruction, in part by influencing the proliferation of cells responding to the injury.
Eye-head-hand coordination during visually guided reaches in head-unrestrained macaques
Authors: Arora Harbandhan Kaur , Bharmauria Vishal , Yan Xiaogang , Sun Saihong , Wang Hongying , Crawford John Douglas
Published: September 2019

Nonhuman primates have been used extensively to study eye-head coordination and eye-hand coordination, but the combination—eye-head-hand coordination—has not been studied. Our goal was to determine whether reaching influences eye-head coordination (and vice versa) in rhesus macaques. Eye, head, and hand motion were recorded in two animals with search coil and touch screen technology, respectively. Animals were seated in a customized “chair” that allowed unencumbered head motion and reaching in depth. In the reach condition, animals were trained to touch a central LED at waist level while maintaining central gaze and were then rewarded if they touched a target appearing at 1 of 15 locations in a 40° × 20° (visual angle) array. In other variants, initial hand or gaze position was varied in the horizontal plane. In similar control tasks, animals were rewarded for gaze accuracy in the absence of reach. In the Reach task, animals made eye-head gaze shifts toward the target followed by reaches that were accompanied by prolonged head motion toward the target. This resulted in significantly higher head velocities and amplitudes (and lower eye-in-head ranges) compared with the gaze control condition. Gaze shifts had shorter latencies and higher velocities and were more precise, despite the lack of gaze reward. Initial hand position did not influence gaze, but initial gaze position influenced reach latency. These results suggest that eye-head coordination is optimized for visually guided reach, first by quickly and accurately placing gaze at the target to guide reach transport and then by centering the eyes in the head, likely to improve depth vision as the hand approaches the target.

NEW & NOTEWORTHY Eye-head and eye-hand coordination have been studied in nonhuman primates but not the combination of all three effectors. Here we examined the timing and kinematics of eye-head-hand coordination in rhesus macaques during a simple reach-to-touch task. Our most novel finding was that (compared with hand-restrained gaze shifts) reaching produced prolonged, increased head rotation toward the target, tending to center the binocular field of view on the target/hand.
Postsaccadic eye position contributes to oculomotor error estimation in saccadic adaptation
Authors: Gremmler Svenja , Lappe Markus
Published: September 2019

We investigated whether the proprioceptive eye position signal after the execution of a saccadic eye movement is used to estimate the accuracy of the movement. If so, saccadic adaptation, the mechanism that maintains saccade accuracy, could use this signal in a similar way as it uses visual feedback after the saccade. To manipulate the availability of the proprioceptive eye position signal we utilized the finding that proprioceptive eye position information builds up gradually after a saccade over a time interval comparable to typical saccade latencies. We confined the retention time of gaze at the saccade landing point by asking participants to make fast return saccades to the fixation point that preempt the usability of proprioceptive eye position signals. In five experimental conditions we measured the influence of the visual and proprioceptive feedback, together and separately, on the development of adaptation. We found that the adaptation of the previously shortened saccades in the case of visual feedback being unavailable after the saccade was significantly weaker when the use of proprioceptive eye position information was impaired by fast return saccades. We conclude that adaptation can be driven by proprioceptive eye position feedback.

NEW & NOTEWORTHY We show that proprioceptive eye position information is used after a saccade to estimate motor error and adapt saccade control. Previous studies on saccadic adaptation focused on visual feedback about saccade accuracy. A multimodal error signal combining visual and proprioceptive information is likely more robust. Moreover, combining proprioceptive and visual measures of saccade performance can be helpful to keep vision, proprioception, and motor control in alignment and produce a coherent representation of space.
Diverse physiological properties of hypoglossal motoneurons innervating intrinsic and extrinsic tongue muscles
Authors: Wealing J. C. , Cholanian M. , Flanigan E. G. , Levine R. B. , Fregosi R. F.
Published: September 2019

The mammalian tongue contains eight muscles that collaborate to ensure that suckling, swallowing, and other critical functions are robust and reliable. Seven of the eight tongue muscles are innervated by hypoglossal motoneurons (XIIMNs). A somatotopic organization of the XII motor nucleus, defined in part by the mechanical action of a neuron’s target muscle, has been described, but whether or not XIIMNs within a compartment are functionally specialized is unsettled. We hypothesize that developing XIIMNs are assigned unique functional properties that reflect the challenges that their target muscle faces upon the transition from in utero to terrestrial life. To address this, we studied XIIMNs that innervate intrinsic and extrinsic tongue muscles, because intrinsic muscles play a more prominent role in suckling than the extrinsic muscles. We injected dextran-rhodamine into the intrinsic longitudinal muscles (IL) and the extrinsic genioglossus, and physiologically characterized the labeled XIIMNs. Consistent with earlier work, IL XIIMNs ( n = 150) were located more dorsally within the nucleus, and GG XIIMNs ( n = 55) more ventrally. Whole cell recordings showed that resting membrane potential was, on average, 9 mV more depolarized in IL than in GG XIIMNs ( P = 0.0019), and the firing threshold in response to current injection was lower in IL (−31 ± 23 pA) than in GG XIIMNs (225 ± 39 pA; P < 0.0001). We also found that the appearance of net outward currents in GG XIIMNs occurred at more hyperpolarized membrane potentials than IL XIIMNs, consistent with lower excitability in GG XIIMNs. These observations document muscle-specific functional specializations among XIIMNs.

NEW & NOTEWORTHY The hypoglossal motor nucleus contains motoneurons responsible for innervating one of seven different muscles with notably different biomechanics and patterns of use. Whether or not motoneurons innervating the different muscles also have unique functional properties (e.g., spiking behavior, synaptic physiology) is poorly understood. In this work we show that neonatal hypoglossal motoneurons innervating muscles that shape the tongue (intrinsic longitudinal muscles) have different electrical properties than those innervating the genioglossus, which controls tongue position.
Case studies in neuroscience: a novel amino acid duplication in the NH2-terminus of the brain sodium channel NaV1.1 underlying Dravet syndrome
Authors: Angus Madeline , Peters Colin H. , Poburko Damon , Brimble Elise , Spelbrink Emily M. , Ruben Peter C.
Published: September 2019

Dravet syndrome is a severe form of childhood epilepsy characterized by frequent temperature-sensitive seizures and delays in cognitive development. In the majority (80%) of cases, Dravet syndrome is caused by mutations in the SCN1A gene, encoding the voltage-gated sodium channel NaV1.1, which is abundant in the central nervous system. Dravet syndrome can be caused by either gain-of-function mutation or loss of function in NaV1.1, making it necessary to characterize each novel mutation. Here we use a combination of patch-clamp recordings and immunocytochemistry to characterize the first known NH2-terminal amino acid duplication mutation found in a patient with Dravet syndrome, M72dup. M72dup does not significantly alter rate of fast inactivation recovery or rate of fast inactivation onset at any measured membrane potential. M72dup significantly shifts the midpoint of the conductance voltage relationship to more hyperpolarized potentials. Most interestingly, M72dup significantly reduces peak current of NaV1.1 and reduces membrane expression. This suggests that M72dup acts as a loss-of-function mutation primarily by impacting the ability of the channel to localize to the plasma membrane.

NEW & NOTEWORTHY Genetic screening of a patient with Dravet syndrome revealed a novel mutation in SCN1A. Of over 700 SCN1A mutations known to cause Dravet syndrome, M72dup is the first to be identified in the NH2-terminus of NaV1.1. We studied M72dup using patch-clamp electrophysiology and immunocytochemistry. M72dup causes a decrease in membrane expression of NaV1.1 and overall loss of function, consistent with the role of the NH2-terminal region in membrane trafficking of NaV1.1.
Associations of osteopontin and NT-proBNP with circulating miRNA levels in acute coronary syndrome
Authors: Kwee Lydia Coulter , Neely Megan L. , Grass Elizabeth , Gregory Simon G. , Roe Matthew T. , Ohman E. Magnus , Fox Keith A. A. , White Harvey D. , Armstrong Paul W. , Bowsman Lenden M. , Haas Joseph V. , Duffin Kevin L. , Chan Mark Y. , Shah Svati H.
Published: September 2019

The genomic regulatory networks underlying the pathogenesis of non-ST-segment elevation acute coronary syndrome (NSTE-ACS) are incompletely understood. As intermediate traits, protein biomarkers report on underlying disease severity and prognosis in NSTE-ACS. We hypothesized that integration of dense microRNA (miRNA) profiling with biomarker measurements would highlight potential regulatory pathways that underlie the relationships between prognostic biomarkers, miRNAs, and cardiovascular phenotypes. We performed miRNA sequencing using whole blood from 186 patients from the TRILOGY-ACS trial. Seven circulating prognostic biomarkers were measured: NH2-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein, osteopontin (OPN), myeloperoxidase, growth differentiation factor 15, monocyte chemoattractant protein, and neopterin. We tested miRNAs for association with each biomarker with generalized linear models and controlled the false discovery rate at 0.05. Ten miRNAs, including known cardiac-related miRNAs 25-3p and 423-3p, were associated with NT-proBNP levels (min. P = 7.5 × 10−4) and 48 miRNAs, including cardiac-related miRNAs 378a-3p, 20b-5p and 320a, -b, and -d, were associated with OPN levels (min. P = 1.6 × 10−6). NT-proBNP and OPN were also associated with time to cardiovascular death, myocardial infarction (MI), or stroke in the sample. By integrating large-scale miRNA profiling with circulating biomarkers as intermediate traits, we identified associations of known cardiac-related and novel miRNAs with two prognostic biomarkers and identified potential genomic networks regulating these biomarkers. These results, highlighting plausible biological pathways connecting miRNAs with biomarkers and outcomes, may inform future studies seeking to delineate genomic pathways underlying NSTE-ACS outcomes.
Functional genomic characterization of the FTO locus in African Americans
Authors: Gill Richard , Stratigopoulos George , Lee Joseph H. , Leibel Rudolph L.
Published: September 2019

Background: SNPs in the first intron of the fat mass and obesity-associated ( FTO) gene represent the strongest genome-wide associations with adiposity [body mass index (BMI)]; the molecular basis for these associations is under intense investigation. In European populations, the focus of most genome-wide association studies conducted to date, the single nucleotide polymorphisms (SNPs) have indistinguishable associations due to the high level of linkage disequilibrium (LD). However, in African American (AA) individuals, reduced LD and increased haplotype diversity permit finer distinctions among obesity-associated SNPs. Such distinctions are important to mechanistic inferences and for selection of disease SNPs relevant to specific populations. Methods: To identify specific FTO SNP(s) directly related to adiposity, we performed: 1) haplotype analyses of individual-level data in 3,335 AAs from the Atherosclerosis Risk in Communities Cohort (ARIC) study; as well as 2) statistical fine-mapping using summary statistics from a study of FTO in over 20 000 AAs and over 1000 functional genomic annotations. Results: Our haplotype analyses suggest that in AAs at least two distinct signals underlie the intron 1 FTO-adiposity signal. Fine mapping showed that two SNPs have the highest posterior probability of association (PPA) with BMI: rs9927317 (PPA = 0.94) and rs62033405 (PPA = 0.99). These variants overlap possible enhancer sites and the 5′-regions of transcribed genes in the substantia nigra, chondrocytes, and white adipocytes. Conclusions: We found two SNPs in FTO with the highest probability of direct association with BMI in AAs, as well as tissue-specific mechanisms by which these variants may contribute to the pathogenesis of obesity.
Functional Evaluation of the Visual Pathway in Patients with Multiple Sclerosis Using a Multifunction Stimulator Monitor
Authors: Satue M. , Jarauta L. , Obis J. , Cipres M. , Rodrigo M. J. , Almarcegui C. , Dolz I. , Ara J. R. , Martin J. , Pablo L. E. , Garcia-Martin E.
Published: September 2019

Objectives. To assess the capability of the vision monitor unit Monpack One of detecting visual function alterations in patients with multiple sclerosis (MS) and to evaluate the correlation between structural retinal parameters and functional measurements obtained with this device. Methods. Forty-eight patients with MS and 46 healthy controls were included in a cross-sectional study. All participants underwent a complete functional evaluation of the visual pathway, which included low-contrast visual acuity (LCVA), contrast sensitivity vision (CSV), automated perimetry, multifocal visual evoked potentials (mfVEPs), and pattern electroretinogram (ERG). All tests were performed using the vision monitor unit Monpack One (Metrovision, France), a multifunction stimulator device. Retinal structural measurements were obtained in all subjects using Triton swept source optical coherence tomography (Topcon, Japan). Results. Patients with MS presented reduced low-contrast VA (p<0.001) and reduced CSV at medium (p=0.001, p=0.013) and low (p=0.001, p=0.002) spatial frequencies. All visual field parameters were found to be altered in MS patients compared with controls (≤0.001). Patients with MS presented lower amplitude of the P100 waveform of the mfVEP in areas corresponding to central (p<0.001), inferonasal (p=0.001), and inferotemporal (p=0.003) retina. The pattern ERG did not show significant differences. Significant correlations were observed between structural retinal measurements and functional parameters, especially between the inner macular areas and measurements corresponding to contrast sensitivity and perimetry indexes. Conclusions. Patients with MS present visual dysfunction detectable with the vision monitor unit Monpack One. This device may be a fast and useful tool to provide a full evaluation of axonal damage in patients with multiple sclerosis.
Candidate Animal Disease Model of Elizabethkingia Spp. Infection in Humans, Based on the Systematic Pathology and Oxidative Damage Caused by E. miricola in Pelophylax nigromaculatus
Authors: Huang Xiaoli , Feng Yang , Tang Hong , Xiong Guanqing , Li Liangyu , Yang Yucen , Wang Kaiyu , Ouyang Ping , Geng Yi , Chen Defang , Yang Shiyong
Published: September 2019

Most species of the genus Elizabethkingia are pathogenic to humans and animals, most commonly causing meningitis. However, our understanding of the pathogenic mechanisms involved is poor and there have been few pathological studies of Elizabethkingia spp. in animals. To understand the host injury induced by Elizabethkingia spp., we established a model of E. miricola infection in the black-spotted frog (Pelophylax nigromaculatus). The systematic pathology in and oxidative damage in the infection model were investigated. Our results show that recently isolated E. miricola is a bacterium that mainly parasitizes the host brain and that neurogenic organs are the predominant sites of damage. Infection mainly manifested as severe brain abscesses, meningoencephalitis, necrotic spondylitis, and necrotic retinitis. The liver, spleen, kidney, gastrointestinal tract, and lung were also affected to varying degrees, with bacterial necrotic inflammation. P. nigromaculatus also suffered enormous damage to its oxidative system during E. miricola infection, which may have further aggravated its disease state. Our results provide a preliminary reference for the study and treatment of Elizabethkingia spp.-induced neurological diseases in animals.
Preparation and Self-Repairing Properties of Urea Formaldehyde-Coated Epoxy Resin Microcapsules
Authors: Yan Xiaoxing , Chang Yijuan , Qian Xingyu
Published: September 2019

Urea formaldehyde resin-coated epoxy resin microcapsules were prepared by two-step in situ polymerization. The effects of five factors on the yield, coverage rate, repair rate, and morphology of the microcapsules were investigated by five factors and four levels of orthogonal test. These five factors were the mass ratio of the core to the wall material (Wcore:Wwall), the mass ratio of the emulsifier to the core material (Wemulsifier:Wcore), stirring rate, deposition time, and mass ratio of the emulsifier solution to the core material (Wemulsifier solution:Wcore). The ideal technological level of microcapsule synthesis was determined. According to the results of the range and variance of yield, coverage rate, and repair rate, the comprehensive properties of microcapsules became ideal. At this time, the Wcore:Wwall was 0.8 : 1, Wemulsifier:Wcore was 1 : 100, stirring rate was 600 r/min, deposition time was 32 h, and Wemulsifier solution:Wcore was 8 : 1. When the concentration of microcapsules in the epoxy resin was 10.0%, the self-repair rate was the best and the repair rate was 114.77%. This study is expected to provide a reference value for the preparation of a microcapsule self-healing technology and lay a foundation for the subsequent development of self-healing materials.
Research on Vibration Reduction Design of Foundation with Entangled Metallic Wire Material under High Temperature
Authors: Zhu Yue , Wu Yiwan , Bai Hongbai , Ding Zheyu , Shao Yichuan
Published: September 2019

When the submarine is sailing at full speed, the power cabin has an abnormally high temperature. However, in the previous research on the vibration reduction design of the foundation, the influence of high temperature on the vibration characteristics of the foundation is not taken into account. In this paper, a new composite foundation with entangled metallic wire material (EMWM) is presented to reduce the vibration of the foundation. The energy transfer path of the foundation was obtained by the power flow method, and then the layout of EMWM was determined. The optimization of the constraining layer was carried out by modal analysis. The damping performance of the composite foundation with EMWM was validated by the thermal‐vibration joint test. The results show that, at room temperature, the composite foundation has remarkable vibration reduction efficiency in the middle and high‐frequency bands. The maximum insertion loss can reach 15.37 dB. The insertion loss varies with the location of the excitation point. As the temperature rises to 300°C, the insertion loss in the low‐frequency band was improved, and the insertion loss is not influenced by the excitation position.
Deep Convolutional Neural Network for Ulcer Recognition in Wireless Capsule Endoscopy: Experimental Feasibility and Optimization
Authors: Wang Sen , Xing Yuxiang , Zhang Li , Gao Hewei , Zhang Hao
Published: September 2019

Wireless capsule endoscopy (WCE) has developed rapidly over the last several years and now enables physicians to examine the gastrointestinal tract without surgical operation. However, a large number of images must be analyzed to obtain a diagnosis. Deep convolutional neural networks (CNNs) have demonstrated impressive performance in different computer vision tasks. Thus, in this work, we aim to explore the feasibility of deep learning for ulcer recognition and optimize a CNN-based ulcer recognition architecture for WCE images. By analyzing the ulcer recognition task and characteristics of classic deep learning networks, we propose a HAnet architecture that uses ResNet-34 as the base network and fuses hyper features from the shallow layer with deep features in deeper layers to provide final diagnostic decisions. 1,416 independent WCE videos are collected for this study. The overall test accuracy of our HAnet is 92.05%, and its sensitivity and specificity are 91.64% and 92.42%, respectively. According to our comparisons of F1, F2, and ROC-AUC, the proposed method performs better than several off-the-shelf CNN models, including VGG, DenseNet, and Inception-ResNet-v2, and classical machine learning methods with handcrafted features for WCE image classification. Overall, this study demonstrates that recognizing ulcers in WCE images via the deep CNN method is feasible and could help reduce the tedious image reading work of physicians. Moreover, our HAnet architecture tailored for this problem gives a fine choice for the design of network structure.
Subcritical Water Extraction of Antioxidants from Curculigo latifolia Root
Authors: Zabidi Nur Athirah , Ishak Nur Akmal , Hamid Muhajir , Efliza Ashari Siti
Published: September 2019

This study aims to extract antioxidant compounds from Curculigo latifolia root by subcritical water extraction (SWE). The influence of extraction temperature and time on the antioxidant activity of C. latifolia root extract was investigated in terms of extraction yield, total phenolic content (TPC), total flavonoid content (TFC), 2, 2′-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. The highest extraction yield (36.5%), TPC (92.55 mg GAE/g), TFC (13.26 mg RE/g), and antioxidant activities by ABTS (66.8 mg trolox equivalent/g sample) and DPPH (128.7 mg trolox equivalent/g sample) were detected at 180°C and 30 minutes extraction time. Based on the results, the optimum condition was selected at 180°C and 30 minutes of extraction. The sample was screened by using liquid chromatography-mass spectrometry (LC-MS) analysis where the phenolic compounds detected were structured based on their [M-H]-peak. The detected phenolic compounds were monobenzone, hydroquinone, phloridzin, pomiferin, mundulone, scandenin, and dimethyl caffeic acid. According to these findings, SWE is a promising, environmentally friendly, and efficient technology in the exploitation of natural products for the development of food and nutraceutical commodities.
Identifying the Superior Reperfusion Technique in Liver Transplantation: A Network Meta-Analysis
Authors: Yao Yao , Wu Ping , Guo Tao
Published: September 2019

Objective. To investigate the clinical effects of different reperfusion techniques in liver transplantation based on network meta-analysis. Method. Literature retrieval was conducted in globally recognized databases, namely, MEDLINE, EMBASE, and Cochrane Central, to address relative randomized controlled trials (RCTs) investigating the clinical effects of respective reperfusion techniques in liver transplantation. Short- and long-term parametric data, including ICU stay, dysfunction rate (DFR), biliary complications (BC), 1-year graft survival (GS), and patient survival (PS), were quantitatively pooled and estimated based on the Bayesian theorem. The P values of surface under the cumulative ranking (SUCRA) probabilities regarding each parameter were calculated and ranked by various techniques. The Grades of Recommendations Assessment, Development and Evaluation (GRADE) criteria were utilized for the recommendations of evidence from pairwise direct comparisons. Results. Seven RCTs containing 6 different techniques were finally included for network meta-analysis. The results indicated that retrograde vena cava (RVC) reperfusion possessed the highest possibility of revealing the best clinical effects on DFR (SUCRA, P=0.93), ICU stay (SUCRA, P=0.76), and GS (SUCRA, P=0.44), while portal-arterial reperfusion (simultaneous initialize) seemed to exhibit the most benefits in reducing BC (SUCRA, P=0.67) and enhancing PS rate (SUCRA, P=0.48). Moreover, sensitivity analysis with the inconsistency approach clarified the reliability of the main results, and the evidence of the most direct comparisons was ranked low or very low. Conclusions. Current evidence demonstrated that RVC and portal-arterial reperfusion (simultaneously initialized) revealed superior clinical effects, compared to other interventions. Investigation of these 2 techniques should be a future research direction, and more high-quality RCTs are expected.
Acoustic Correlates of the Four-Way Laryngeal Contrast in Marathi
Authors: Dmitrieva Olga , Dutta Indranil
Published: September 2019

The study examines acoustic correlates of the four-way laryngeal contrast in Marathi, focusing on temporal parameters, voice quality, and onset f0. Acoustic correlates of the laryngeal contrast were investigated in the speech of 33 native speakers of Marathi, recorded in Mumbai, India, producing a word list containing six sets of words minimally contrastive in terms of laryngeal specification of word-initial velar stops. Measurements were made for the duration of prevoicing, release, and voicing during release. Fundamental frequency was measured at the onset of voicing following the stop and at 10 additional time points. As measures of voice quality, amplitude differences between the first and second harmonic (H1–H2) and between the first harmonic and the third formant (H1–A3) were calculated. The results demonstrated that laryngeal categories in Marathi are differentiated based on temporal measures, voice quality, and onset f0, although differences in each dimension were unequal in magnitude across different pairs of stop categories. We conclude that a single acoustic correlate, such as voice onset time, is insufficient to differentiate among all the laryngeal categories in languages such as Marathi, characterized by complex four-way laryngeal contrasts. Instead, a joint contribution of several acoustic correlates creates a robust multidimensional contrast.
Comparative Analysis of Radial Forearm Free Flap and Anterolateral Thigh Flap in Tongue Reconstruction after Radical Resection of Tongue Cancer
Authors: Cai Yong-Cong , Li Chao , Zeng Din-fen , Zhou Yu Qiu , Sun Rong Hao , Shui Chun Yan , Pei Jiao , Liu Wei , Wang Xu , Jiang Zheng Hua , Tang Zheng Qi , Jiang Jian , Wang Wei
Published: September 2019

Background: Surgery is still the preferred treatment for tongue cancer. Reconstruction should be performed immediately after extensive resection of the tumor. The purpose of this study was to investigate the clinical effect, advantages, and disadvantages of radial forearm free (RFF) flap and anterolateral thigh (ALT) flap in tongue reconstruction after radical resection of tongue cancer. Methods: Thirty-nine cases of tongue reconstruction with RFF flap or ALT flap from 2014 to 2018 were analyzed. The survival of the flap, the functional status after repair, and the influence on the donor area were examined, in addition to the advantages and disadvantages of the flap and the critical points of the technique. Results: Twenty-one cases with RFF flaps and 18 cases with ALT flaps showed complete flap survival. Among them, 1 case involved a venous vessel crisis after an ALT operation, and the flap survived after reoperation after thrombus removal and anastomosis. The recovery of tongue function was as follows: 41.0% patients exhibited normal speech, 43.6% patients exhibited near-normal speech, 12.8% patients exhibited vague speech, and 2.6% patients could not speak. There was no significant difference between the 2 groups (p = 0.134). The recovery of tongue flexibility was as follows: 41.0% of the patients had normal postoperative tongue flexibility, 43.6% of the patients had slightly limited tongue flexibility, 12.8% of the patients had severely limited tongue flexibility, and 2.6% of the patients were completely limited. The difference between the 2 groups was statistically significant (p = 0.045). The postoperative diet of patients was as follows: 51.3% of patients had a regular diet, 33.3% of patients had soft foods, 12.8% of patients received a fluid diet, and 2.6% of patients could not eat after the operation. There was no significant difference between the 2 groups (p = 0.209). The satisfaction of donor area was as follows: 46.2% of the patients were satisfied with the donor area, 51.3% of the patients were basically satisfied with the donor area satisfaction, and 2.6% of the patients were not satisfied with the donor area satisfaction. There was no significant difference between the 2 groups (p = 0.809). Conclusion: The RFF flap is the most widely used technique in tongue reconstruction, especially in patients with tongue defects less than half of tongue tissue. However, for a large number of tissue defects caused by radical resection of advanced tongue cancer, the ALT flaps can provide a sufficient tissue volume, conceal scars after the operation, cause fewer complications in the donor area, and facilitate tongue function and aesthetic quality.
Cell-Free Fetal DNA in the Early and Late First Trimester
Authors: Miltoft Caroline Borregaard , Rode Line , Bundgaard Jens René , Johansen Peter , Tabor Ann
Published: September 2019

Objective: The aim of this work was to investigate the association between maternal and fetal characteristics and the fetal fraction at 8–14 weeks’ gestation, with emphasis on the change in the fetal fraction upon repeat sampling. Method: One sample for cell-free DNA (cfDNA) testing was collected at the same time as the biochemical markers for combined first trimester screening (visit 1) and another at the nuchal translucency scan (visit 2). Chromosome-selective cfDNA analysis was performed on frozen plasma. Results: Overall, 321 women were included at visit 1, and 307 had a repeat blood sampling. A fetal fraction was obtained in 532 samples (238 samples with repeat fetal fraction). The fetal fraction decreased with maternal BMI (p < 0.001), was lower in Asian women (p = 0.03), and increased with β-hCG levels (p < 0.001) and gestational age (p = 0.04). Before 10 weeks’ gestation, the fetal fraction was lower (p = 0.02), as was the probability of a sufficient fetal fraction (p = 0.03) after adjustment for maternal BMI. Asian women had a higher increase in fetal fraction upon repeat sampling (p < 0.001). Conclusion: Before 10 weeks’ gestation, the fetal fraction is significantly lower but seems to increase more rapidly compared to later gestations. Presently, combined first trimester screening with cfDNA testing should not include samples before 10 weeks’ gestation.
Case Series: Minocycline-Associated Thyroiditis
Authors: Millington Kate , Charrow Alexandra , Smith Jessica
Published: September 2019

Introduction: Minocycline, a member of the tetracycline class of antibiotics, has been associated with benign thyroid pigmentation but reports of thyroid dysfunction are sparse. Methods: Cases were selected via an inquiry of the electronic medical records for patients with thyroid dysfunction and the use of a tetracycline antibiotic. Non-autoimmune thyroiditis was defined as abnormally low or suppressed thyroid-stimulating hormone (TSH, <0.3 µIU/mL), elevated free thyroxine or total thyroxine, and undetectable antithyroid antibodies. Results: Nine cases of thyroiditis without autoimmunity were identified out of 423 reviewed patients. Cases of thyroiditis occurred in adolescents ages 14–17 years who had been taking minocycline for 6 months to 4 years. In all cases, minocycline was prescribed for the treatment of acne. Four of the 9 received treatment for thyrotoxicosis with a β-blocker (in 3 cases) and/or antithyroid drug (in 2 cases). Thyroiditis was symptomatic in all but one individual who presented with painless goiter. All thyroiditis was transient and resolved after a median of 4.5 months (range 2–5 months). In one case, thyroiditis was followed by transient hypothyroidism. Discussion: Minocycline is known to cause thyroid abnormalities, although it has not been definitively linked to thyroid dysfunction. Here, we report 9 cases of non-autoimmune thyroiditis in adolescents receiving minocycline for acne. We recommend that minocycline exposure be considered in the differential diagnosis for thyroiditis and that patients receiving minocycline be counseled regarding the risk of thyroid dysfunction.
Traumatic Dorsoradial Trapezium-Metacarpal Joint Dislocation
Authors: Maalouly Joseph , Aouad Dany K. , Ayoubi Rami , Dib Nabil , Wehbe Joseph
Published: September 2019

A trapezium-metacarpal joint dislocation is a rare pathology reported in <1% of all hand injuries. Due to the rarity of this type of injury, no clear standard of treatment exists. Various treatment approaches are reported in the relevant literature, mainly consisting of anterior and posterior dislocation of the trapezium-metacarpal joint. In this case, a 38-year-old patient was treated for dorsoradial trapezium-metacarpal joint dislocation through open reduction with ligamentous reconstruction. Gradual improvement of the patient’s thumb mobility was observed following several physiotherapy sessions.
Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeutic Classes
Authors: Marston Nicholas A. , Giugliano Robert P. , Im KyungAh , Silverman Michael G. , O’Donoghue Michelle L. , Wiviott Stephen D. , Ference Brian A. , Sabatine Marc S.
Published: September 2019

Background:

Randomized trials of therapies that primarily lowered triglycerides have not consistently shown reductions in cardiovascular events.

Methods:

We performed a systematic review and trial-level meta-regression analysis of 3 classes of lipid-lowering therapies that reduce triglycerides to a greater extent than they do low-density lipoprotein cholesterol (LDL-C): fibrates, niacin, and marine-derived omega-3 fatty acids. Key inclusion criteria were a randomized controlled trial that reported major vascular events. We also incorporated data from a previous meta-regression of 25 statin trials. The main outcome measure was the risk ratio (RR) for major vascular events associated with absolute reductions in lipid parameters.

Results:

A total of 197 270 participants from 24 trials of nonstatin therapy with 25 218 major vascular events and 177 088 participants from 25 trials of statin therapy with 20 962 major vascular events were included, for a total of 374 358 patients and 46 180 major cardiovascular events. Starting with non–high-density lipoprotein cholesterol, a surrogate for very-low-density lipoproteins and low-density lipoproteins, the RR per 1-mmol/L reduction in non–high-density lipoprotein cholesterol was 0.79 (95% CI, 0.76–0.82;
P
<0.0001; 0.78 per 40 mg/dL). In a multivariable meta-regression model that included terms for both LDL-C and triglyceride (surrogates for low-density lipoproteins and very-low-density lipoproteins, respectively), the RR was 0.80 (95% CI, 0.76–0.85;
P
<0.0001) per 1-mmol/L (0.79 per 40 mg/dL) reduction in LDL-C and 0.84 (95% CI, 0.75–0.94;
P
=0.0026) per 1-mmol/L (0.92 per 40 mg/dL) reduction in triglycerides. REDUCE-IT (Reduction of Cardiovascular Events With Icosapent Ethyl–Intervention Trial) was a significant outlier and strongly influential trial in the meta-regression. When removed, the RRs became 0.79 (95% CI, 0.76–0.83;
P
<0.0001) per 1-mmol/L (0.78 per 40 mg/dL) reduction in LDL-C and 0.91 (95% CI, 0.81–1.006;
P
=0.06) per 1-mmol/L (0.96 per 40 mg/dL) reduction in triglycerides. In regard to omega-3 dose, each 1 g/d eicosapentaenoic acid administered was associated with a 7% relative risk reduction in major vascular events (RR, 0.93 [95% CI, 0.91–0.95];
P
<0.0001), whereas there was no significant association between the dose of docosahexaenoic acid and the relative risk reduction in major vascular events (RR 0.96 [95% CI, 0.89–1.03]).

Conclusions:

In randomized controlled trials, triglyceride lowering is associated with a lower risk of major vascular events, even after adjustment for LDL-C lowering, although the effect is less than that for LDL-C and attenuated when REDUCE-IT is excluded. Furthermore, the benefits of marine-derived omega-3 fatty acids, particularly high-dose eicosapentaenoic acid, appear to exceed their lipid-lowering effects.
Redescription of Amerila abdominalis (Rothschild, 1933), a little-known species of tiger moth from Southeast Asia (Lepidoptera: Erebidae: Arctiinae)
Authors: SPITSYN VITALY M. , POTAPOV GRIGORY S.
Published: September 2019

The genus Amerila Walker, 1855 is widely distributed from Africa to Australia with the maximum diversity in Africa (Häuser 1993, Häuser & Boppré 1997). Three species in this genus are recorded from Indochina (Dubatolov & de Vos 2010), including A. astreus (Drury, 1773) and A. omissa (Rothschild, 1910). These two are common and widely distributed, and their external morphology is well studied (Holloway 1988, Černý & Pinratana 2009, Bucsek 2012) and their genitalia are illustrated in the book of Dr. J.D. Holloway (1988). However the third one, A. abdominalis (Rothschild, 1933) is a rather poorly known species. The morphology of this species is known only from its original description (Rothschild 1933). There are no published images of genitalia of this species, and its female morphology is unknown. The image of a male of A. abdominalis was published by Bucsek (2012). Here, we give the detailed description of the morphology of A. abdominalis, including the male and female genitalia.
Reports of two peculiar pigmented new species of genus Homidia (Collembola: Entomobyridae) from Southern China, with description of subadults chaetotaxy
Authors: PAN ZHI-XIANG , YANG WAN-QIN
Published: September 2019

Two new species with peculiar pigmentation of the genus Homidia from Guangdong Province, Southern China are described here, Homidia chroma sp. nov. and Homidia leniseta sp. nov. H. chroma is characterized by chrome pigmentation on lateral side of terga, two macrochaetae on medial abdominal segment (Abd.) III and six macrochaetae on postero-medial Abd. IV, up to 68 sensory chaetae present on Abd. IV, and five apical smooth chaetae on posterior face of ventral tube. H. leniseta is easily identified by unique colour pattern, smooth labial chaetae l2, G1–4 and H1–3, and short trichobothria on Abd. II–IV. Illustrations of adults of this two new species, chaetotaxy of the first instar larvae of H. chroma and subadults of H. leniseta are provided herein.
A new species of freshwater crab of the genus Strengeriana Pretzmann, 1971, from El Jardín Natural Reserve, Quindío, Colombia (Crustacea: Decapoda: Pseudothelphusidae)
Authors: CAMPOS MARTHA R. , CAMACHO ROSA
Published: September 2019

A new species of Strengeriana Pretzmann, 1971, is described from the El Jardín Natural Reserve, Quindío Department, Colombia, on the western slope of the Central Andes. The genus is endemic to Colombia and is distributed in the Sierra Nevada de Santa Marta, and the Western and Central Andes, at elevations ranging from 700 to 2400 m. With the addition of the new species, Strengeriana now includes 17 species. Strengeriana quindiensis n. sp. is distinguished from its congeners mainly by the exopod of the third maxilliped being 0.92 times the length of the ischium and by the morphology of the first male gonopod, particularly the shapes of the mesial and lateral processes.
Two new species and a key to the dustywings of Mexico (Neuroptera, Coniopterygidae)
Authors: SARMIENTO-CORDERO MARIZA ARACELI , CONTRERAS-RAMOS ATILANO
Published: September 2019

Two new species of Coniopterygidae are described from Mexico: Neoconis szirakii sp. n. and Coniopteryx (Scotoconiopteryx) josephus sp. n., increasing the number of recorded species of dustywings from Mexico to 43. Descriptions and illustrations are based primarily on male genitalia. A key to the known species of Coniopterygidae from Mexico is included.
How Tropical Pacific Surface Cooling Contributed to Accelerated Sea Ice Melt from 2007 to 2012 as Ice Is Thinned by Anthropogenic Forcing
Authors: Baxter Ian , Ding Qinghua , Schweiger Axel , L’Heureux Michelle , Baxter Stephen , Wang Tao , Zhang Qin , Harnos Kirstin , Markle Bradley , Topal Daniel , Lu Jian
Published: September 2019

Over the past 40 years, the Arctic sea ice minimum in September has declined. The period between 2007 and 2012 showed accelerated melt contributed to the record minima of 2007 and 2012. Here, observational and model evidence shows that the changes in summer sea ice since the 2000s reflect a continuous anthropogenically forced melting masked by interdecadal variability of Arctic atmospheric circulation. This variation is partially driven by teleconnections originating from sea surface temperature (SST) changes in the east-central tropical Pacific via a Rossby wave train propagating into the Arctic [herein referred to as the Pacific–Arctic teleconnection (PARC)], which represents the leading internal mode connecting the pole to lower latitudes. This mode has contributed to accelerated warming and Arctic sea ice loss from 2007 to 2012, followed by slower declines in recent years, resulting in the appearance of a slowdown over the past 11 years. A pacemaker model simulation, in which we specify observed SST in the tropical eastern Pacific, demonstrates a physically plausible mechanism for the PARC mode. However, the model-based PARC mechanism is considerably weaker and only partially accounts for the observed acceleration of sea ice loss from 2007 to 2012. We also explore features of large-scale circulation patterns associated with extreme melting periods in a long (1800 yr) CESM preindustrial simulation. These results further support that remote SST forcing originating from the tropical Pacific can excite significant warm episodes in the Arctic. However, further research is needed to identify the reasons for model limitations in reproducing the observed PARC mode featuring a cold Pacific–warm Arctic connection.
A Multiscale Alignment Method for Ensemble Filtering with Displacement Errors
Authors: Ying Yue
Published: September 2019

High-resolution models nowadays simulate phenomena across many scales and pose challenges to the design of efficient data assimilation methods that reduce errors at all scales. Smaller-scale features experience rapid nonlinear error growth that gives rise to displacement errors, which cause suboptimal ensemble filter performance. Previous studies have started exploring methods that can reduce displacement errors. In this study, a multiscale alignment (MSA) method is proposed for ensemble filtering. The MSA method iteratively processes the model state from the largest to the smallest scales. At each scale, an ensemble filter is applied to update the state with observations, and the analysis increments are utilized to derive displacement vectors for each member that align the ensemble at smaller scales before the next iteration. The nonlinearity in smaller-scale priors is reduced by removing larger-scale displacement errors. Because the displacement vectors are derived from analysis increments in the state space rather than the nonlinear observation-space cost function formulated in previous studies, this method provides a less costly and more robust way to solve for the displacement vectors. Observing system simulation experiments using a two-layer quasigeostrophic model were conducted to provide a proof of concept of the MSA method. Results show that the MSA method significantly improves the accuracy of posteriors compared to the existing ensemble filter methods with or without multiscale localization. Advantage of the MSA method are more evident when the ensemble size is relatively small and the cycling period is comparable to the average eddy turnover time of the dynamical system.
The Lived Experience of Professional Mentorship and Its Implications for School-Based Mentoring Programs
Authors: McNeven Sean , McKay Loraine , Main Katherine
Published: September 2019

School-based mentoring (SBM) is an intervention that addresses the disengagement of “at-risk” youth. Currently, empirical evidence that SBM may help to stem youth disengagement remains largely inconclusive and inconsistent, and few studies have sought to examine the relational element of SBM. This article reports on a study that used a hermeneutic phenomenological methodology to identify and describe the constructs that constitute the lived experiences of two professional mentors working with young adolescents. The study’s analysis revealed the mentor–mentee relationship as the principal operative element of such programs and identified mechanisms for the successful generation of mentor–mentee relational quality.