bluuebunny/crossref_metadata_2025 huggingface dataset:
Law Enforcement in the Practice of Bribery in Business and Trade in Indonesia: Between Theory and Practice
Authors: Atikasari Hartini , Amira Btari , Arifin Ridwan
Published: March 2022

Abstract: Abuse of power for the sake of business and trade profit has become an increasingly average occurrence in the practice of public procurement in this era of moral disruption. It is commonplace that government officials make an illicit arrangement with companies through bribery scheme to win tenders in the procurement of goods and services. This practice resulted in a shift of ideology and abuse of authority by government officials. This practice is contrary to the professional code of ethics, so it is necessary to settle such cases through juridical channels. The intervention of public officials in determining the award of contracts of government projects to certain parties has resulted in a crisis of public trust in law enforcement in Indonesia. This article reviews the basic principles of the criminal act of corruption and the commitment and integrity of government officials in implementing the professional code of ethics, and upholding honesty in order to achieve equitable law enforcement. This paper proves and confirms that the abuse of power by government officials for the sake of business profit in the public procurement has weakened Indonesia’s investment sector. In many cases, these activities may even lead to unfair competition in the trade and business sectors.Abstrak: Memperdagangkan otoritas guna melancarkan praktik bisnis dan perdagangan merupakan hal yang banyak terjadi di era disrupsi moral ini. Para pejabat pemerintah sering kali bekerja sama dengan para pengusaha dengan cara membantu memberikan stimulus berupa kemenangan tender dalam pengadaan barang dan jasa. Praktik tersebut mengakibatkan terjadinya penyalahgunaan wewenang oleh para pejabat pemerintah. Hal ini bertentangan dengan kode etik profesi, sehingga diperlukan penyelesaian perkara melalui jalur yuridis. Adanya intervensi pejabat publik dalam penetapan pihak yang menangani proyek pemerintah menyebabkan terjadinya krisis kepercayaan publik terhadap penegakan hukum di Indonesia. Artikel ini menelaah ulang dasar pokok aturan-aturan tentang tindak pidana korupsi serta bagaimana komitmen dan integritas para pejabat pemerintah dalam melaksanakan kode etik profesi, menjunjung tinggi kejujuran guna mewujudkan penegakan hukum yang adil. Tulisan ini membuktikan dan menegaskan bahwa perdagangan otoritas dalam praktik bisnis melemahkan sektor investasi Indonesia. Pada banyak kasus, kegiatan ini bahkan cenderung memperkuat kondisi persaingan tidak sehat dalam sektor perdagangan dan bisnis.
Konsekuensi Yuridis Putusan MKRI No. 137/PUU-XIII/2015 terhadap Pergeseran Kewenangan Pengujian Peraturan Daerah dan Peraturan Kepala Daerah Kabupaten/Kota oleh Gubernur
Authors: Kartika Adhitya Widya
Published: March 2022

Abstract: The dynamics of the local government system follow the dynamics of the law that overshadows it. Constitutional Court Decision No. 137/PUU-XIII/2015 has caused a shift in the power to review regional regulations district/city and even other legal structures in the regional government system. This shift in authority affects the implementation of local government functions, particularly at the district/city level. This article examines the consequences of shifting the authority to review regional regulations and regional head regulations for districts/cities. This study uses a regulatory approach and legal doctrine with a juridical analysis method. From the study that has been carried out, it is concluded that the testing of district/city regulations was initially carried out by the governor in the regional legislation process. However, since the Constitutional Court Decision No. 137/PUU-XIII/2015, the governor no longer has the authority to do so. The authority to review district/city regulations is transferred to the Supreme Court. This shift of authority was initially an oversight executive review but later became a judicial review. However, the governor has the authority to limit the implementation of autonomy in regent/mayor regulations, but not to district/city regional regulations, which are also an element of deconcentration.Abstrak: Dinamika sistem pemerintahan daerah mengikuti dinamika hukum yang menaunginya. Putusan Mahkamah Konstitusi RI No. 137/PUU-XIII/2015 telah menyebabkan terjadinya pergeseran kekuasaan pengujian peraturan daerah (perda) kabupaten/kota bahkan struktur hukum lain pada sistem pemerintahan daerah. Pergeseran kewenangan ini mempengaruhi pelaksanaan fungsi pemerintahan daerah, khususnya di tingkat kabupaten/kota. Artikel ini mengkaji tentang konsekuensi pergeseran kewenangan pengujian peraturan daerah dan peraturan kepala daerah (perkepda) kabupaten/kota. Penelitian ini menggunakan pendekatan peraturan dan doktrin hukum dengan metode analisis yuridis. Dari kajian yang telah dilakukan diperoleh simpulan bahwa pengujian perda kabupaten/kota pada mulanya dilakukan oleh gubernur pada proses legislasi daerah. Akan tetapi semenjak adanya putusan Mahkamah Konstitusi No. 137/PUU-XIII/2015, gubernur tidak lagi memiliki kewenangan untuk itu. Adapun kewenangan pengujian perda kabupaten/kota beralih kepada Mahkamah Agung. Pergeseran kewenangan ini awalnya merupakan pengawasan executive review namun kemudian menjadi judicial review. Namun demikian, gubernur memiliki kewenangan melakukan pembatasan terhadap implementasi otonomi dalam peraturan bupati/walikota, tetapi tidak terhadap peraturan daerah kabupaten/kota yang juga merupakan unsur dekonsentrasi.
Crítica de la experiencia del tiempo en el mundo contemporáneo
Authors: Forero Fernando
Published: March 2022

El mundo moderno creó un régimen temporal de horarios, presiones, exigencias de efectividad, rendimientos, etc., que somete a los individuos a procesos de alienación, pero esa lógica temporal no ha sido suficientemente politizada ni se ha llegado a ver qué pasa con nuestra experiencia de tiempo. La lógica temporal de la modernidad parece natural. El propósito de este artículo es volver sobre la realidad del tiempo. Aquí nos apoyamos en un primer momento en el proyecto crítico de Hartmut Rosa y lo conectamos con una consideración del tiempo que debemos buscar en otros autores, presuntamente ajenos a la teoría crítica, a saber, Heidegger y Gadamer.
Cambio climático y desobediencia coercitiva
Authors: García Gibson Francisco
Published: March 2022

Este artículo sostiene que la desobediencia coercitiva motivada por el cambio climá-tico a veces es antidemocrática, pero no por eso es impermisible. El cambio climático representa un peligro tan grave para los derechos básicos de millones de personas en todo el mundo, que incluso el derecho básico a la democracia puede verse justificadamente desplazado como medio para disminuir el riesgo de una catástrofe climática. El artículo responde también a quienes afirman que la desobediencia coercitiva climática es siempre democrática porque sirve para igualar la influencia informal sobre las decisiones públicas o protege las precondiciones de la democracia. Estos argumentos solo rescatan algunos actos de desobediencia climática coercitiva. Los demás son antidemocráticos, pero no por eso impermisibles.
Vital Labors: Transacting Oocytes across Borders in the Post-Soviet Space
Authors: Reeves Madeleine
Published: March 2022

Anthropological accounts of labor mobility in the post-Soviet region have tended to focus on the commoditization, securitization, and illegalization of migrant wage labor, rather than on the generation of surplus through the harnessing of mobile life itself. Bringing together discussions of “clinical labor” (Cooper and Waldby 2014) with analysis of migrant wage work, the essay explores strategies of transnational recruitment for supposed Asian oocyte vendors by Russian, Georgian, and Ukrainian fertility clinics seeking to meet a growing demand for donor eggs for Chinese commissioning couples. In this bioeconomy, value is generated from the differential mobility and transactional value of human and nonhuman bodies, body parts, and genetic material across territorial, administrative, and juridical borders. The essay investigates how the recruitment of oocyte vendors intersects with other unequal circuits of movement to argue for an expanded account of labor migration in the post-Soviet space.
Gambling, Dignity, and the Narcotic of Time in Tokyo’s Day-Laborer District, San’ya
Authors: Hammering Klaus K. Y.
Published: March 2022

This article examines the social practice of gambling among stigmatized construction workers in Tokyo’s vanishing day laborer district, San’ya. By considering the abstract temporality of surplus extraction imposed on the manual laborer at the construction site, and the deadening effects of this discipline on his sensorial experience of the world, the article demonstrates how the enactment of masculinity through gambling involves a transformation of the abstract time of the working day into what Walter Benjamin has described as a “narcotic.” Whereas manual labor demands that the construction worker shield and numb himself against interruptive contingencies of accidents and material stimuli, the gambler seeks an embodied exposure to the penetrating contingency of victory or defeat in a moment of risk. The article argues that the form of this transformation of time propels the gambler, and that it is through debt and credit that he actualizes his reputation as a man.
Tarekat dan Modal Sosial dalam Sistem Pendidikan Nahdlatul Wathan, 1966-1997
Authors: Rasyad Abdul , Dienaputra Reiza D. , Zakaria Mumuh Muhsin , Mulyadi Raden Muhammad
Published: March 2022

Tarekat [Islamic congregation] is always interesting to be studied, including the Tarekat Hizib that developed in the Islamic organization of Nahdlatul Wathan (NW). This paper aims to explain the development and exposes a system of tarekat education and understand the social capital relations involved in the NW organization. This study is a historical study which is carried out in four stages, namely heuristics, criticism, interpretation, and historiography. According to the study, the education system developed by NW combines the salafiyyah [An education system that condemns theological innovation and advocates strict adherence to shari'a and to the social structures existing in the earliest days of Islam] and khalafiyyah, in which on the one hand maintains the traditional education in pesantren [Islamic boarding schools], but on the other hand also follows government regulations in implementing the national education system. Meanwhile, tarekat relations in the tarekat education system become a social capital in the religious life of NW followers and shaping the characteristics and personality of the community as well as the spiritual messages outlined by the tarekat founders. During the period 1966 to 1997, it was the main period as well as the antithesis in changing the orientation of the spiritual life perspective among the NW followers which has been getting stronger.
Bagaimana Menulis Biografi Audiovisual Poststrukturalis?
Authors: Wijaya I Nyoman
Published: March 2022

Poststructuralist audiovisual biography is written using a poststructuralist historical approach and audiovisual archives. This study presents a new method in writing concise and concise biographies for the purpose of making papers and publication articles. The problem is focused on how the writing technique is? Like poststructuralist history, this biography model departs from the actor's present situation in the past. The goal is to explore the actor’s experience that brought him to where he is now. The actor’s successness or failureness today depend on the capital (resources) he has. Are these resources in accordance with the profession? Resources are formed from habits that have undergone internalization to form habits as a guide for actors in thinking and acting when dealing with social reality. Considering this biography model is relatively unknown to academics and history students in genera. This study also discusses the method to write biography as well as the theory that can be used as a basis for thinking. Thus, Bourdieu's generative structural theory is considered very relevant to be used.
Bahasa sebagai Jejaring Budaya Asia Tenggara
Authors: Suwignyo Agus
Published: March 2022

The connection of Southeast Asian region was a result of migration and trade. While this holds true according to the mainstream studies, there has been a growing scholarly attention paid to the role of languages. Languages significantly shaped the roots of cultural identity of the region. The aim of this paper is to examine languages as an objective factor in the construction of Southeast Asian cultural connection. This paper argues that the linguistic roots of Southeast Asia created shared elements of cultural identities by which Southeast Asian nations had developed. In the nineteenth and twentieth century, the shared elements moved into different trajectories of identities especially as they were fostered by the formation of colonial and post-colonial states. Although today the nations of Southeast Asia speak of their own “national language”, the same language elements remain to exist. This shows a strong sense of shared elements on which the cultural network of Southeast Asian region was based.
Pertunjukan Kethoprak Ngesti Pandowo, 1950-1996
Authors: Utama Mahendra Pudji , Puguh Dhanang Respati , Amaruli Rabith Jihan
Published: March 2022

The study about Ngesti Pandowo's kethoprak performance is always enchanting because not enough attention yet been got in various studies. This article discusses the Ngesti Pandowo's kethoprak performance in the period of the 1950s-1996 using the historical method. Kethoprak has been performed by Ngesti Pandowo since the early independence of Indonesia. In it’s heyday in the 1950-1970s, kethoprak had receded and only to provide entertainment to the audience in the different type. In the 1980s, Ngesti Pandowo began entered a receding period. Its prestige as a kitsch theater began faded because the the main artists died and was no successor. It was no more creative artists who capable becoming maecenas. In this situation, Ngesti Pandowo's kethoprak performances have actually increased and can be a salvage lid to keep getting viewers.
On the nonlinear perturbations of self-adjoint operators
Authors: Bełdziński Michał , Galewski Marek , Majdak Witold
Published: March 2022

Using elements of the theory of linear operators in Hilbert spaces and monotonicity tools we obtain the existence and uniqueness results for a wide class of nonlinear problems driven by the equation

T
x
=
N

(

x

)

Tx=N\left(x)

, where

T

T

is a self-adjoint operator in a real Hilbert space

ℋ

{\mathcal{ {\mathcal H} }}

and

N

N

is a nonlinear perturbation. Both potential and nonpotential perturbations are considered. This approach is an extension of the results known for elliptic operators.
Lipschitz estimates for partial trace operators with extremal Hessian eigenvalues
Authors: Vitolo Antonio
Published: March 2022

We consider the Dirichlet problem for partial trace operators which include the smallest and the largest eigenvalue of the Hessian matrix. It is related to two-player zero-sum differential games. No Lipschitz regularity result is known for the solutions, to our knowledge. If some eigenvalue is missing, such operators are nonlinear, degenerate, non-uniformly elliptic, neither convex nor concave. Here we prove an interior Lipschitz estimate under a non-standard assumption: that the solution exists in a larger, unbounded domain, and vanishes at infinity. In other words, we need a condition coming from far away. We also provide existence results showing that this condition is satisfied for a large class of solutions. On the occasion, we also extend a few qualitative properties of solutions, known for uniformly elliptic operators, to partial trace operators.
Experimental and analytical study on the behavior of hybrid GFRP/steel bars in reinforced concrete deep beams
Authors: Shoeib Ata El-Kareim , Arafa Ahmed Noureldean Mohamed , El Rady Ramy Abd El-Hakeem Abd , Tawhed Waleed Mohamed Fouad
Published: March 2022

The deep beam is one of the essential members of high-rise buildings structures, so the deep beams are used as a transfer girder; in walls water structures, the deep beam behavior is different from the slender beam behavior; the deep beam plane section before does not remain plane after bending. In recent years, the use of FRP as a composite material in reinforced concrete structures has been growing up to cover problems by weight of structure buildings, corrosion, repairing, and construction cost. This paper presents an experimental, analytical study to assign the variation of mechanical properties of reinforced concrete deep beams using vertical and horizontal GFRP stirrups. This paper investigates the mechanical properties of test specimens for deep beams reinforced in shear with GFRP or steel bars as web reinforcement. The deep beams are reinforced with glass fiber reinforced polymer (GFRP) in various ratios as a web reinforcement configuration (0, 0.25%, and 0.40%) rather than traditional steel web reinforcement. All tested specimens have the same span to depth ratio of 0.40 (a/d); the primary and secondary reinforcement is steel bars. The web reinforcement ratio significantly affected deep beams’ load capacity and mechanical behavior. The GFRP enhancement the mechanical behavior of the reinforced concrete deep. Increasing the GFRP web reinforcement ratio enhances the deep beam load capacity. The test results compared with the traditional ACI design method strut-tie model to demonstrate the effect of web reinforcement ratio on deep beam load capacity and strut width. The test results have been verified by ABAQUS 6.13.
TLP diffusion bonding of C–C composite and TC4 alloy using AgCuNiLi alloy as joining material
Authors: Wang Jie , Li Ge , Yang Haotian , Li Penghao , Liu Jing , Feng Yang , Fang Qingyu , Luo Han
Published: March 2022

In this study, AgCuNiLi alloy was successfully used as the intermediate layer to join Ti-6Al-4V (TC4) alloy and silicon carbide (SiC) coated carbon–carbon (C–C) composites by transient liquid phase diffusion bonding (TLP). Through the characterization and analysis of microstructure, element distribution, phases and fracture behavior of as-prepared joints by optical microscopy, scanning electron microscope, energy dispersive X-ray spectrometry, X-ray diffraction, mechanical testing etc., the influences of the SiC coating on the surface of C–C composites on the microstructure and mechanical properties of the joints were studied. Experimental results indicate that joints with a gradient structure of “C–C|SiC coating|Ti–Cu intermetallic|Ag-based solid solution|Ti–Cu intermetallic|diffusion layer|TC4” can be formed during the bonding procedure. The presence of SiC coating greatly improves the continuity and density of the interfacial layer adjacent C–C composites, which is beneficial to the overall performance of the joint. The average shear strength of as-prepared joint achieves 26.5 MPa, and the fracture tends to occur along the interface of C–C|SiC and adjacent areas.
Analysis of the expression and prognostic value of MT1-MMP, β1-integrin and YAP1 in glioma
Authors: Zhai Yangyang , Sang Wei , Su Liping , Shen Yusheng , Hu Yanran , Zhang Wei
Published: March 2022

Increased expression of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP14) is associated with the development of many cancers. MT1-MMP may promote the entry of yes-associated protein1 (YAP1) into the nucleus by regulating the regulation of β1-integrin. The purpose of this study was to investigate the effects of MT1-MMP, β1-integrin and YAP1 on the prognosis of gliomas. The expression of proteins was detected by bioinformatics and immunohistochemistry. The relationship between three proteins and clinicopathological parameters was analyzed by the χ
2 test. Survival analysis was used to investigate the effects of three proteins on prognosis. The results showed that high expressions of MT1-MMP, β1-integrin and YAP1 were found in glioblastoma (GBM) compared with lower-grade glioma (LGG). There was a significantly positive correlation between MT1-MMP and β1-integrin (r = 0.387), MT1-MMP and YAP1 (r = 0.443), β1-integrin and YAP1 (r = 0.348). Survival analysis showed that patients with overexpression of MT1-MMP, β1-integrin and YAP1 had a worse prognosis. YAP1 expression was the independent prognostic factor for progression-free survival (PFS). There was a statistical correlation between the expression of MT1-MMP and YAP1 and isocitrate dehydrogenase 1 (IDHl) mutation. Thus, this study suggested that MT1-MMP, β1-integrin and YAP1, as tumor suppressors, are expected to be promising prognostic biomarkers and therapeutic targets for glioma patients.
Oscillation and Property B for Semi-Canonical Third-Order Advanced Difference Equations
Authors: Chatzarakis G.E. , Srinivasan R. , Thandapani E.
Published: March 2022

In this paper, we present sufficient conditions for the third-order nonlinear advanced difference equations of the form

Δ

(

a

(
n
)

)

Δ

(

b

(
n
)

Δ
y

(

(
n
)

)

)

=
p

(
n
)

f

(

y

(

σ

(
n
)

)

)

\Delta \left( {a\left( n \right)} \right)\Delta \left( {b\left( n \right)\Delta y\left( {\left( n \right)} \right)} \right) = p\left( n \right)f\left( {y\left( {\sigma \left( n \right)} \right)} \right)

to have property B or to be oscillatory. These conditions are based on monotonic properties and estimates of nonoscillatory solutions of corresponding canonical type equations. The obtained results extended and improve known results mentioned in the literature.
Nanocolloid simulators of luminescent solar concentrator photovoltaic windows
Authors: Darwish Abdalla M. , Sarkisov Sergey S. , Patel Darayas N. , Mele Paolo , Latronico Giovanna , Wilson Simeon , Cho Kyu , Giri Anit , Koplitz Brent , Hui David
Published: March 2022

Transparent luminescent solar concentrator (LSC) windows with edge-attached photovoltaic (PV) cells have the potential for improving building efficiency without compromising aesthetics and comfort. Optimization of such windows requires an inexpensive simulator for experimenting with various designs. We report, for the first time to the best of our knowledge, the simulator of a transparent LSC window in the form of a plastic container filled with a colloid of photoluminescent nanoparticles (NPs) in an organic solvent (1-propanol). The exemplary NPs were produced by ball milling of the powder of rare earth (RE)-doped phosphor NaYF4:Yb3+,Er3+ synthesized by the wet method. The NPs converted the ultraviolet (UV) solar spectrum into visible/near infrared (NIR) via spectral down-shifting and down-conversion (quantum cutting). With a photoluminescence quantum yield (PLQY) of the phosphor <0.4%, the LSC at a nanocolloid concentration of ∼0.1 g solids per 100 mL liquids demonstrated a power conversion efficiency of 0.34% and a power concentration ratio of ∼0.022 comparable to the LSCs with RE-doped NPs with 200 times greater PLQY. At the same time, the 3 cm thick LSC window simulator had ∼90% transmittance to the sunlight. The content and concentration of the nanocolloid could be easily modified to optimize the LSC window performance without a costly window making process.
Compressive strength and anti-chloride ion penetration assessment of geopolymer mortar merging PVA fiber and nano-SiO2 using RBF–BP composite neural network
Authors: Zhang Xuemei , Zhang Peng , Wang Tingya , Zheng Ying , Qiu Linhong , Sun Siwen
Published: March 2022

In this study, we investigated the mechanical properties and chloride ion permeation resistance of geopolymer mortars based on fly ash modified with nano-SiO2 (NS) and polyvinyl alcohol (PVA) fiber and metakaolin (MK) at dose levels of 0–1.2% for PVA fiber and 0–2.5% for NS. The Levenberg–Marquardt (L–M) back propagation (BP) neural network, as well as the radial-based function (RBF) neural network, was used to predict the compressive strength and chloride ion permeation resistance of the geopolymer mortar with different admixtures of nanoparticles and PVA fiber, wherein the electric flux value was used as the index for chloride ion permeation performance. The RBF–BP composite neural network was constructed to study the compressive strength and chloride ion permeation resistance of nanoparticle-doped and PVA fiber ground geopolymer mortars. According to the experimental results of the RBF–BP composite neural network model, the mean square error (MSE) was observed to be 0.00071943, root mean square error (RMSE) was 0.026822, and mean absolute error (MAE) was 0.026822, thereby showing higher prediction accuracy, faster convergence, and better fitting effect compared with the single BP neural network and RBF neural network models. In this study, we combined the RBF–BP composite artificial neural network, providing a new method for the future assessment of the compressive strength and chloride ion penetration resistance of geopolymer mortar merging PVA fibers and NS in experiments and engineering studies.
Akzeptanz der CO2-Bepreisung in Deutschland: Die große Bedeutung einer Rückverteilung der Einnahmen
Authors: Frondel Manuel , Helmers Viola , Mattauch Linus , Pahle Michael , Sommer Stephan , Schmidt Christoph M. , Edenhofer Ottmar
Published: March 2022

Im Jahr 2021 wurde in Deutschland die sogenannte CO2-Bepreisung fossiler Kraft- und Brennstoffe eingeführt, um deren Verbrauch zum Zwecke des Klimaschutzes zu reduzieren. Dieser Preisaufschlag auf fossile Energieträger wird in den kommenden Jahren sukzessive erhöht. In diesem Beitrag untersuchen die Autoren die Akzeptanz der CO2-Bepreisung für die Zeit vor Einführung des CO2-Preises im Jahr 2019. Eine Erhebung unter mehr als 6.000 Haushalten zeigt, dass eine leichte absolute Mehrheit von 53,7 Prozent der Befragten grundsätzlich bereit ist, zu Klimaschutzzwecken höhere Kosten in Kauf zu nehmen. Die Zustimmung zu einer CO2-Bepreisung nimmt jedoch mit sinkendem Einkommen deutlich ab: Bei Befragten der untersten Einkommensgruppe liegt die Zustimmungsrate knapp unter 40 Prozent. Erwartungsgemäß verringert sich die Zustimmung auch mit der Höhe des CO2-Preises. So wurde ein CO2-Preis von 50 Euro von einer Mehrheit der Befragten von 50,6 Prozent abgelehnt. Um bei bis zum Jahr 2025 auf 55 Euro steigenden CO2-Preisen die mehrheitliche Akzeptanz der Bürger zu gewinnen, wird hier für einen breit angelegten Ausgleichsmechanismus durch die Reduzierung verzerrender und sozial ungerechter Steuern und Abgaben auf den Strompreis plädiert, die insbesondere Gering- und Durchschnittsverdienern zugutekommt. Andernfalls könnten die über die Zeit steigenden CO2-Preise eine hohe soziale Sprengkraft entfalten.
Método para identificar el dispositivo de captura de una imagen digital no manipulada basado en la distancia de Hellinger
Authors: Quintanar Reséndiz Ana Laura , Hernández Sánchez Jerónimo de Jesús , Juárez Santiago Brenda , Santos Osorio Rene , Ledesma Uribe Norma Alejandra , Vázquez Medina Rubén
Published: March 2022

Se propone un método basado en la distancia de Hellinger y la función de densidad de probabilidad de señales (Photo Response Non-Uniformity [PRNU]) para identificar el dispositivo de captura de imágenes digitales. El método asocia una imagen digital no modificada (imagen en disputa) con uno de un conjunto de dispositivos de captura candidatos, al comparar la huella digital insertada en la imagen en disputa contra la base de datos creada con las huellas digitales de los dispositivos de captura. El método propuesto se implementó en MatlabTM para demostrar su funcionamiento, luego se comparó en un caso de estudio controlado contra dos métodos diferentes: uno propuesto por Goljan et al. (2009) con un porcentaje de similitud promedio del 100% y el otro por Quintanar-Reséndiz et al. (2021) con el 99.35%, y para el método propuesto resultó ser de 97.68%.
BURSA İLİ KIRSAL BÖLGELERİNDEKİ İÇME SUYU AMAÇLI KULLANILAN KUYU SULARININ AĞIR METAL SEVİYELERİNİN BELİRLENMESİ
Authors: KURT Ayşe , KANDER Selman , ÇOPUR Ömer Utku
Published: March 2022

Bu çalışma kapsamında Bursa ili kırsal bölgelerindeki 10 farklı noktadan içme suyu amaçlı kullanılan kuyu suyu toplanmış ve analiz edilmiştir. Numunelerin içerdikleri ağır metallerin ortalama seviyeleri (µg/L); Cu (183.40) > Fe (86.29) > Al (55.75) > Mn (20.2) > Cr (7.33) > Cd (5) > Ni (2.54) > As (2.23) > Se (1.99) > Pb (1.55) > Hg (1) > Sb (0.70) > B (0.0002) olarak bulunmuştur. Tüm kuyu sularına ait su kalite indeksi (WQI) değerleri < 50 olduğu için su kaliteleri DSÖ (2011) kriterlerine göre “mükemmel” olarak tanımlanmıştır. Ağır metal kirliliği (HPI) değerleri <100 olduğundan sağlık açısından olumsuz etkilere yol açmadığı sonucuna varılmıştır. Ağır metal değerlendirme indeksi (HEI) <10 ve çok düşük değerlerde olduğundan sonuçlar su kaynaklarında kayda değer bir kirliliğin olmadığını göstermiştir. Tüm kuyulara ait suların maksimum kirletici seviyeleri (MCL) EPA (2018)’e göre 0.01 mg/L’nin altında olup insan ve hayvan için kanserojen risk içermemektedirler.
Histological, functional and transcriptomic alterations in the juvenile hippocampus in a mouse model of thyroid hormone resistance
Authors: Fang Yingxin , Dang Pingping , Liang Yue , Zhao Defa , Wang Ranran , Xi Yue , Zhang Dan , Wang Wei , Shan Zhongyan , Teng Weiping , Teng Xiaochun
Published: March 2022

Background

Proper thyroid hormone signaling via the TRα1 nuclear receptor is required for normal neurodevelopmental processes. The specific downstream mechanisms mediated by TRα1 that impact brain development remain to be investigated.

Methods

In this study, the structure, function and transcriptome of hippocampal tissue in a mouse model expressing the first RTHα mutation discovered in a patient, THRA
E403X, were analyzed. RNAscope was used to visualize the spatial and temporal expression of Thra1 mRNA in the hippocampus of WT mice, which is corresponding to THRA1 mRNA in humans. The morphological structure was analyzed by Nissl staining, and the synaptic transmission was analyzed on the basis of long-term potentiation. The Morris water maze test and the zero maze test were used to evaluate the behavior. RNA-seq and quantitative real-time PCR were used to analyze the differentially expressed genes (DEGs) of the hippocampal tissues in the mouse model expressing the Thra
E403X mutation.

Results

The juvenile mutant Thra
E403X mice presented with delayed neuronal migration, disordered neuronal distribution, and decreased synaptic plasticity. A total of 754 DEGs, including 361 upregulated genes and 393 downregulated genes, were identified by RNA-seq. DEG-enriched Gene Ontology (GO) and KEGG pathways were associated with PI3K-Akt signaling, ECM−receptor interaction, neuroactive ligand−receptor interaction, and a range of immune-related pathways. 25 DEGs were validated by qPCR.

Conclusions

The ThraE403X mutation results in histological and functional abnormalities, as well as transcriptomic alterations in the juvenile mouse hippocampus. This study of the ThraE403X mutant offers new insights into the biological cause of RTHα-associated neurological diseases.
Design of Experiment Method – An Application in Improving Quality of Magnesium Hydroxide Produced from Natural Seawater Bittern
Authors: Le-Minh Tam , Hoang Dong Nam , Nguyen Tan Dzung
Published: March 2022

Seawater bittern is an important resource for production of magnesium hydroxide. It is particularly meaningful for countries of which long beaches and high temperatures are available as natural advantages. This production process bases on the main reaction between solutions containing magnesium and various alkaline agents. Among of precipitants, lime slurry is frequently used as an inexpensive reactant. However, the contamination of calcium in the final magnesium hydroxide is a major problem which limits applicability of this product in many fields required extremely high quality of magnesium hydroxide such as pharmaceuticals, and catalyst, etc. In this work, magnesium hydroxide with more than 99% purity will be recovered from natural seawater bitterns by using the design of experiment (DOE) method. Selected from nine potential factors, a full factorial design considering four main effects was applied to construct a second-order regression model which allows predicting favorable conditions to pursuit high purity of magnesium hydroxide from multi-component seawater bittern and lime milk. On the one hand, the results for a 1.0 L batch investigation proved that factors such as concentration of Ca(OH)2 in lime suspension and residence time have strong negative influences on the product purity, besides positive effects of reaction temperature. On the other hand, magnesium concentration in the bittern was absent in the regression model. At the optimal conditions, the chemical purity of the solid product was obtained at a value of 99.35%. Thus, this product, and therefore its corresponding production conditions, can be recommended for applications required high quality of magnesium hydroxide.
Efectividad de la autovacuna en un caso de papilomavirus canino en un perro Gran Danés en Costa Rica
Authors: Alfaro-Mora Ramsés , Dolz Gaby
Published: March 2022

El objetivo del presente estudio fue determinar la efectividad de una autovacuna para papilomas ocasionados por papilomavirus canino (CPV) en la región facial de un perro Gran Danés de tres meses. Se colectó un grupo de papilomas de la cara del paciente y se analizaron mediante técnicas moleculares (amplificación de un segmento del gen que codifica para la proteína L1 mediante PCR y secuenciación). Para el análisis de la secuencia se utilizó el algoritmo BLAST. El estudio histológico se realizó mediante tinción de hematoxilina-eosina del tejido y análisis en microscopio de luz a 20X. Se elaboró una autovacuna a partir de los papilomas escindidos, la cual fue administrada intradérmica en cuatro ocasiones a intervalos de siete días. Se estableció la presencia de CPV genotipo 1 en el papiloma analizado. La histopatología estableció formación de papilas epidérmicas exofíticas soportadas por un corion fibrovascular con hiperqueratosis (ortoqueratotica) e hiperplasia del estrato espinoso y con queratinocitos (coilocitos). Los papilomas desaparecieron después de la tercera aplicación de la autovacuna. Este es el primer reporte de CPV-1 en Costa Rica. La autovacuna mostró ser un tratamiento eficaz en el manejo de papilomatosis facial en el paciente.
Actividad ovárica y comportamiento reproductivo posparto de vacas de doble propósito con y sin suplementación en el trópico subhúmedo de México
Authors: Armenta-Carmona Julia , Centurión-Castro Fernando , Magaña-Monforte Juan Gabriel , Delgado-León Roger , Segura-Correa José Candelario , Aguilar-Pérez Carlos
Published: March 2022

El objetivo del trabajo fue caracterizar la actividad ovárica y el comportamiento reproductivo posparto de vacas de doble propósito en pastoreo con y sin suplementación. Se utilizaron 30 vacas multíparas Bos taurus x Bos indicus en la zona centro del estado de Yucatán, México. El peso y la condición corporal (CC) se registraron semanalmente y los ovarios fueron monitoreados mediante ecografía cada dos días. Se registró el número y el diámetro de los folículos, así como la presencia o no de cuerpo lúteo (CL). Solamente se consideró la presencia de folículos grandes (>10 mm). Se determinó como actividad ovárica: el intervalo parto-primer folículo dominante (IPPF), el tiempo de permanencia del primer folículo dominante (TPPF), el número de folículos dominantes antes del primer estro (NFDAE) y antes del primer cuerpo lúteo (NFDACL), y como desempeño reproductivo el intervalo parto-primer estro (IPPE), el intervalo parto-primer cuerpo lúteo (IPPCL) y la tasa de preñez (TP). Los efectos de la suplementación fueron significativos para la pérdida de peso y CC, TPPFD, IPPE (p<0.05). La suplementación alimenticia mitigó las pérdidas de peso y CC pero tuvo efecto mínimo sobre la actividad ovárica y desempeño reproductivo posparto.
Valor nutricional, producción de gas in vitro y degradación ruminal in situ de ensilaje de maíz enriquecido con Saccharomyces cerevisiae
Authors: Aragadvay-Yungán Ramon , Barros Rodríguez Marcos , Basantes-Basantes Edwin , Carrasco Cando Ángela
Published: March 2022

El objetivo del estudio fue valorar nutricionalmente al ensilaje de maíz (EMz) enriquecido con Saccharomyces cerevisiae (Sc) y cuantificar la producción de gas in vitro y degradación ruminal in situ. Los tratamientos fueron T0: EMz, T1: EMz + 10% Sc, T2: EMz + 20% Sc. El contenido de fibra neutro detergente (FND) y fibra ácido detergente (FAD) mostró una tendencia lineal decreciente con respecto al incremento de los niveles de Sc y fue menor en T1 y T2 en comparación con T0. La digestibilidad de la materia orgánica y energía metabolizable (EM) mostró una tendencia lineal decreciente a medida que los niveles de Sc fueron adicionados. The lowest in vitro gas production corresponded to T1 (118.75 ml gas/0.5 g MSF). The greater amount of soluble fraction degraded in situ was evidenced in T2 (328.12 g/kg MS), also showing an increasing linear trend with the addition of Sc. It is concluded that the enrichment with 20% of Sc in the elaboration of EMz showed a lower production of gas in vitro and favoured the parameters the rumen degradation in situ.
Microplásticos en el “cangrejo peludo” Romaleon setosum (Molina, 1782) (Cancridae) del Perú
Authors: Iannacone José , Príncipe Fabiola , Alvariño Lorena , Minaya David , Panduro Grober , Ayala Yuri
Published: March 2022

El objetivo de esta investigación fue caracterizar los microplásticos (MP) en el cangrejo peludo Romaleon setosum (Molina, 1782) (Cancridae), especie de importancia para el consumo humano. Se evaluaron 15 individuos de R. setosum adquiridos entre diciembre de 2020 y enero de 2021 en el Mercado Mayorista Pesquero de Ventanilla, Callao, Perú. El músculo, branquia y tracto digestivo de cada cangrejo fue sometido a digestión con KOH al 10%, seguido por un proceso de filtración para la búsqueda de los MP. Todos los individuos presentaron MP en músculo, branquias y tracto digestivo. Las fibras azules de MP fueron más abundantes en el músculo, las azules y rojas en la branquia, y el negro y azul en el tracto digestivo. En el caso del MP tipo film, el color blanco fue el dominante en el músculo y en el tracto digestivo, en tanto que el verde se observó en las branquias. Para los fragmentos, el color azul fue el más abundante en la branquia y en el tracto digestivo, no siendo observado en el músculo. El número de partículas de MP se presentó con la siguiente secuencia: tracto digestivo > branquia > músculo y con relación a su forma fue fibra > fragmento > film. Los MP de color azul y negro fueron los dominantes. La longitud del cefalotórax se observó relacionada con el número de partículas de MP totales, con el músculo y con el color azul.
Relative contribution of liver disease risk factors in the Prediction of liver diseases using artificial intelligence
Authors: Alkhatib Ahed J
Published: March 2022

The liver is a key organ that filters blood from the digestive tract before it is passed on to the rest of the body. Liver illnesses are diverse, and liver function tests, such as alanine transaminase (ALT), can be used to diagnose them. The study's major goals were to employ neural network analysis to forecast liver disease and to determine the relative contribution of different liver disease predictors. A Kaggle dataset of Indian liver patients was used to do the analysis for liver disease prediction. There were 583 people in the study, and 71.4 percent of them had liver disease. Age, gender, ALT, aspartate aminotransferase (AST), bilirubin, albumin, total protein, albumin/globulin ratio, and alkaline phosphatase were all included as predictors in the study. The prediction model was successful in predicting liver illness in 79.6% of cases. ALT was the most important predictor, while alkaline phosphatase was the least important. Overall, neural network analysis is effective in predicting liver illness from one perspective, and it may be enhanced to provide more accurate results from the other perspective
Molecular characterisation and phylogenetic study of the fusion gene of Newcastle disease viruses isolated from broiler farms of Iran in 2018-2019
Authors: Allahyari E. , Allymehr M. , Molouki A. , Fallah Mehrabadi M. H. , Talebi A.
Published: March 2022

Avian orthoavulavirus, commonly known as Newcastle disease virus (NDV) has been a constant threat for the poultry industry of Iran for decades. Recently, a couple of preliminary studies on backyard and commercial chicken suggested that a major subgenotype circulating in Iran may be VII(L) subgenotype, which is now known as VII.1.1 according to the new classification system. The unique subgenotype was not reported from other parts of the world and was slightly (≥3%) different from the closest group that was VIId. The study was conducted between July 2018 and March 2019 to determine the exact NDV genotypes/subgenotypes circulating in Iranian broiler poultry farms; five-hundred and forty chickens were sampled from thirty-six broiler farms located in eighteen provinces of Iran. As other genotypes/subgenotypes such as XIII and VI.2 are circulating in neighbouring countries, border provinces were also sampled. The F gene of the NDV isolates was sequenced and phylogenetic analysis was conducted. All the isolates clustered under the VII.1.1 group. The evolutionary analysis also revealed that the distances were between 0.0 and 0.7% meaning that the Iranian NDV circulating in broiler farms were not only of VII.1.1 sub-genotype, but also genetically very identical, indicating that the routine control measures for ND in Iran were not able to prevent the circulating NDVs. Although stricter biosecurity measures have been really effective in developed countries, surveillance of NDV to determine the circulating genotypes might also help us to implement better vaccination strategies in the future.
Cytotoxicity of the Fusarium mycotoxin deoxynivalenol on mammalian and avian cell lines
Authors: Todorova K. , Georgieva A. , Milcheva R. , Ivanov D. , Kalkanov I.
Published: March 2022

Trichothecenes are mycotoxins that occur in grains and can lead to acute and chronic poisoning in animals and humans. Deoxynivalenol (DON) is a type B trichothecene affecting protein synthesis, immune system, leading to brain, blood and kidney disorders. The aim of this work was to evaluate in vitro the cytotoxicity and the pathological effects of DON in short-term experiments on cells from non-tumour and tumour permanent cell lines and to compare their sensitivity. Cell cultivation of BALB/c 3T3, DEC 99, MDA-MB-231, MCF-7 and Hela cells was performed. Quantitative and qualitative methods evaluating cytotoxicity on the base of statistical and morphological analyses for determining the impact on the viability and proliferative activity were used: Neutral Red Uptake (NRU) cytotoxicity test, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test and fluorescence microscopy. The cytotoxic effect of DON was assessed after an exposure period of 24 h. DON treatment induced significant alterations in the growth and morphology of the cells, involving early and late apoptosis and necrosis signs. Statistically significant decrease of the viability of all cell lines was established at concentrations of DON starting from 1.9 µg/mL to 3.7 µg/mL, the mean IC50 concentrations were calculated. According to the IC50 values the hierarchical order of cell lines’ sensitivity was determined.
New records and range extension of Euphractus sexcinctus (Linnaeus, 1758) (Cingulata, Chlamyphoridae) in Rondônia state, Brazil
Authors: Barbosa Raul Afonso Pommer , Oliveira Marcela Alvares
Published: March 2022

We report two new records of occurrence of Six-banded Armadillo, Euphractus sexcinctus (Linnaeus, 1758), in the state of Rondônia, Brazil, based on roadkills. These new records extend the geographic distribution of this species by 70 km. The records are from the region with a high deforestation rate called the “Arc of Deforestation”, which includes the state of Rondônia. Euphractus sexcinctus was recorded in an area with a high loss of vegetation cover, where the forest is being converted to pasture.
Complications of diagnostics of rare congenita mitochondrial pathology — the combined deficit of the oxidizing phosphorylating 26 in a child of early age: clinical case
Authors:   Bukovynian State Medical University, Chernivtsi, Ukraine, Koloskova O.K. , Koliubakina L.V. ,   Bukovynian State Medical University, Chernivtsi, Ukraine, Bohutska N.K. ,   Bukovynian State Medical University, Chernivtsi, Ukraine, Tkachuk R.V. ,   Bukovynian State Medical University, Chernivtsi, Ukraine
Published: March 2022

Hereditary mitochondrial diseases are a consequence of congenital errors in energy metabolism with very variable and predominantly multisystem manifestations, they require differential diagnosis with a wide range of phenotypically similar nosologies, and their verification is a complex problem with a need of a multidisciplinary approach. The article describes a rare clinical case diagnosed in a girl of early age of a congenital mitochondrial pathology with autosomal recessive inheritance — a combined oxidative phosphorylation deficiency of type 26 (COXPD-26) due to two mutations in the heterozygous state of the TRMT5 gene (tRNA methyltransferase 5) on the chromosome 14q23. The patient's illness was accompanied by a debut from birth and was characterized by insufficient weight gain, manifestations of cardiomyopathy, repeated intercurrent infectious diseases with increased activity of blood transaminases, creatine kinase-MB, hepatopathy with hypoalbuminemia, convulsive syndrome, intolerance to valproic acid, progressive delay in stato-kinetic and psychoverbal development, that is, the symptomatology was characterized by progression, multisystem character with predominant damage to the heart, liver and nervous system. The diagnostic algorithm for mitochondrial diseases is one of the most complex in medical practice. In young children, persistent or progressive multisystem disorder of unknown etiology, unknown multiple complex neurological manifestations or neurological monosymptom with involvement of other systems, less often — specific clinical symptoms; persistent lactic acidosis, other positive or questionable laboratory screening findings are suspicious of probable mitochondrial pathology. Numerous hospitalizations, repeated consultations by different specialists, multiple additional labtests, and multiple conflicting diagnoses may indicate a possible mitochondrial pathology. Only whole exome sequencing of a blood sample with an analysis of variations in the number of copies of genes and genomic sequencing of a new generation with targeted genetic testing made it possible to diagnose in a child a hereditary metabolic disorder from the group of defects in the mitochondrial respiratory chain — a combined deficiency of oxidative phosphorylation type 26, previously described in only a few patients. The research was carried out in accordance with the principles of the Helsinki declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: mitochondrial pathology, combined deficiency of oxidative phosphorylation of type 26 (COXPD-26), clinical case.