bluuebunny/crossref_metadata_2025 huggingface dataset:
A mild method for the synthesis of β-enaminones and β-enamino esters using KH2PO4 as catalyst
Authors: Xu Feng , Lv Hong-Xia , Wang Jin-Ping , Tian You-Ping , Wang Jian-Jun
Published: December 2009

β-Enaminones and β-enamino esters have been produced by the direct condensation of amines with β-diketones and β-ketoesters using KH2PO4 as catalyst under mild, solvent-free conditions.
Synthesis of 1,3-thiazin-2-ylidene-substituted hydrazides via reaction of N-substituted-hydrazino-carbothioamides with 1,4-diphenylbut-2-yne-1,4-dione
Authors: Aly Ashraf A. , Hassan Alaa A. , Ibrahim Yusria R.
Published: December 2009

1,4-Diphenylbut-2-yne-1,4-dione reacts with N-substituted-hydrazino-carbothioamides to form the corresponding N’-6-benzoyl-4-phenyl-2H-1,3-thiazin-2-ylidene]-substituted-hydrazides.
AI2O3/MeSO3H (AMA) as a Novel Heterogeneous System for the Nitration of Aromatic Compounds by Magnesium Nitrate Hexahydrate
Authors: Hosseini-Sarvari Mona , Tavakolian Mina
Published: December 2009

Mg(NO3)2.6H2O was an efficient nitrating agent in the presence of a mixture of AI2O3/MeSO3H (AMA) as a novel heterogeneous system for the nitration of aromatic compounds without use of any organic solvents and with high selectivity. The reaction proceeds at room temperature for the nitration of highly reactive aromatic compounds such as phenols and anilines.
Synthesis and Conformational Studies of 2,11-Dithia[3]Metacyclo-[3](1,3)Pyrenophanes: The Ring Current Interactions Derived from Pyrene Ring
Authors: Paudel Arjun , Shimizu Tomoe , Hu Jian-yong , Yamato Takehiko
Published: December 2009

A series of 2,11-dithia[3]metacyclo[3](1,3)pyrenophanes are obtained by the coupling reaction of the corresponding 1,3-bis(bromomethyl)pyrene and bis(sulfanylmethyl)benzenes in ethanol under the high dilution conditions. The conformational studies of dithia[3]metacyclo[3](1,3)pyrenophanes as well as the ring current interactions derived from pyrene ring are described.
Fused quinoline heterocycles VIII. Synthesis of polyfunctionally substituted pyrazolo[4,3-c]quinolin-4(5H)-ones
Authors: Mekheimer Ramadan Ahmed , Refaey Saeed M. , Sadek Kamal Usef , Hameed Afaf Mohamed Abdel , Ibrahim Mohamed Ashry , Shah Anamik
Published: December 2009

Reaction of 2,4-dichloroquinoline-3-carbonitrile (1) with 4-methylpiperidine gave 2-chloro-4-(4-methylpiperidin-1-yl)quinoline-3-carbonitrile (2). Acid hydrolysis of 2 afforded the corresponding 2-quinolinones 3, which were N-alkylated in DMF to form the 1-methyl, -ethyl and -phenacyl quinolinones 6a–c. Fusion of 6a–c with hydrazine hydrate gave the 3-aminopyrazolo[4,3-c]quinolin-4-ones 8a–c. Diazotisation of 8a,b followed by reaction with sodium azide afforded the novel 3-azidopyrazolo[4,3-c]quinolin-4-ones 9a,b.
Addition–cyclisation of 3-(2-thienyl)acryloyl isothiocyanate with hydrazine derivatives as a source of triazoles and thiadiazoles
Authors: Hemdan Magdy M.
Published: December 2009

3-(2-Thienyl)acryloyl isothiocyanate reacts additively with hydrazine hydrate, phenylhydrazine, 2-pyridyl hydrazine, (thio) semicarbazides, as well as benzoyl- and ethoxycarbonyl hydrazine. Simultaneous or subsequent cyclisation of the resulting 1:1 adducts in acidic or alkaline media yields substituted 1,3,4-thiadiazoles or 1,2,4-triazoles respectively.
Synthesis, characterisation, cytotoxicity and radioprotective effect of novel chiral nitronyl nitroxyl radicals
Authors: Qin Xiang-Yang , Ding Gui-Rong , Wang Xiao-Wu , Tan Juan , Guo Guo-Zhen , Sun Xiao-Li
Published: December 2009

Nitroxyl compounds have been previously investigated as potential radioprotection drugs. To develop new radioprotectors, two kinds of novel chiral nitronyl nitroxyl radicals: L- tert-butyl 2-(4, 5-dihydro-4, 4, 5, 5-tetramethyl-3-oxido-1 H-imidazol-3-ium-1-oxyl-2-yl) pyrrolidine-1-carboxylate ( L-NNP) and L- tert-butyl 2-[(4-(4, 5-dihydro-4,4,5,5-tetramethyl-3-oxido-1 H-imidazol-3-ium-1-oxyl-2-yl)-2-methoxyphenoxy)methyl] pyrrolidine-1-carboxylate ( L-NNVP) have been synthesised. The cytotoxic and radioprotective effects of these two compounds were then evaluated in rat glioma C6 cells.
Synthesis and conformational studies of 9-methoxy- and 9-methyl-2,11-dithia[3.3]metacyclophanes
Authors: Shimizu Tomoe , Maeda Takayuki , Hida Katsuhiro , Yamato Takehiko
Published: December 2009

A series of 9-methoxy- and 9-methyl-2,11-dithia[3.3]metacyclophanes are obtained by the coupling reaction of the corresponding 1,3-bis(bromomethyl)benzenes and bis(sulfanylmethyl)benzenes in ethanol under the high dilution conditions. The conformational studies of 2,11-dithia[3.3]metacyclophanes as well as the ring current interactions derived from benzene ring are also described.
An efficient synthesis of pyridazinoindazolones
Authors: Teimouri Mohammad Bagher , Mansouri Farideh
Published: December 2009

An efficient synthesis of biologically interesting pyridazinoindazolone derivatives was achieved via a one-pot three-component p-toluenesulfonic acid-catalysed reaction of dimedone, differently substituted aldehydes, and 3,6-dihydroxypyridazine under solvent-free conditions. Two plausible mechanisms for the formation of pyridazinoindazolones are proposed.
Synthesis, anti-virus and anti-tumour activities of dibenzylbutyrolactone lignans and their analogues
Authors: Xia Yamu , You Jia , Zhang Yuanyuan , Su Zhongliang
Published: December 2009

An efficient synthesis of dibenzylbutyrolactone lignans and their analogues has been developed. Based on a Stobbe condensation of piperonal or veratraldehyde with diethylsuccinate and alkylation with 3,4-methylenedioxybenzyl bromide to give the skeleton of the lignan. The (±)-diacid was resolved with quinine and the functional groups were transformed to obtain three benzylbutyrolactone lignans and seven analogues. Four natural lignans were prepared by this method, and five lignans were synthesised for the first time. The synthesised compounds were evaluated for anti-HIV, anti-HSV, and anti-tumour activities. Results showed that the dibenzylbutyrolactone lignans and their analogues were inactive against HIV Tat transactivation and HSV-1 in vitro, but some compounds displayed significant activity against MDA-MB-435 human breast cancer cell.
A facile stereoselective synthesis of 1,3-dienyl and 1,4-dienyl sulfides by hydrostannylation-Stille tandem reaction of acetylenic sulfides
Authors: Yao Fang , Hao Wenyan , Cai Mingzhong
Published: December 2009

1,3-Dienyl and 1,4-dienyl sulfides can be stereoselectively synthesised in one pot under mild conditions in good yields by the palladium-catalysed hydrostannylation of acetylenic sulfides, followed by Stille coupling with alkenyl or allylic halides, respectively.
Synthesis and structures of 8-(tolylmethyl)[2.2]metacyclophanes and 8,8′-(ethane-1,2-diyl)bis(16-methoxy[2.2]metacyclophane)
Authors: Shimizu Tomoe , Tanaka Kan , Paudel Arjun , Yamato Takehiko
Published: December 2009

A convenient preparation of 8-(tolylmethyl)[2.2]metacyclophanes and 8,8′-(ethane-1,2-diyl)bis(16-methoxy[2.2]meta-cyclophane) using a cross-coupling reaction of 8-bromomethyl[2.2]metacyclophanes with tolylmagnesium bromides is described. The structures of these novel [2.2]metacyclophanes in solution are also discussed.
Synthesis of imidazo- and pyrazolothiadiazoles from dithiobiureas and dimethyl ethynedicarboxylate
Authors: Ibrahim Yusria R.
Published: December 2009

Microwave irradiation of 1-substituted-2, 5-dithiobiureas and 1, 6-disubstituted-2, 5-dithiobiureas with dimethyl ethynedicarboxylate gave methyl 2-{6-oxo-2-(substituted amino)imidazo-[2, 1- b][1, 3, 5]thiadiazol-5(6 H)-ylidene} acetate and methyl 7-oxo-1, 3-bis(substituted imino)-3, 7-dihydro-1 H-pyrazolo[1, 2- c][1, 3, 4]thiadiazole-5-carboxylate. Rationales for these transformations are presented.
Facile synthesis of novel tacrine analogues
Authors: Hu Huanan , Zhang Anjiang , Ding Lisheng
Published: December 2009

The synthesis of highly potent and selective acetylcholinesterase inhibitors, tacrine analogues with the structure of fused 4-aminoquinolines and 4-aminopyridines, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazoles with cyclic ketones using tin(IV) chloride as catalyst.
A new guaiane sesquiterpene from Paraixeris pinnatipartita
Authors: Shen Tong , Weng Cheng Wu , Xie Wei Dong , Row Kyung Ho
Published: December 2009

A new guaiane sesquiterpene, 3α,9α-dihydroxy-11βH-guai-4(15),10(1)-dien-12,6β-lactone, along with five known compounds were isolated from the whole plants of Paraixeris pinnatipartita. Their structures were identified on the basis of spectroscopic methods, including IR, EI-MS, HR-ESI-MS, 1D NMR and 2D NMR.
Iodine catalysed synthesis and antibacterial evaluation of thieno-[2,3-d]pyrimidine derivatives
Authors: Bakavoli Mehdi , Bagherzadeh Ghodsieh , Vaseghifar Maryam , Shiri Ali , Pordeli Parvaneh
Published: December 2009

A new route via iodine catalysed heterocyclisation of 2-amino-4,5-dimethylthiophene-3-carboxamide with aromatic aldehydes affording a series of thieno[2,3- d]pyrimidine derivatives in a single step have been developed. Some of these compounds exhibited antibacterial activities comparable to Streptomycin as reference drug.
Synthesis and crystal structure of cis-4-azido-L-proline methyl ester hydrochloride
Authors: Gong Jianzhi , Gong Yanqing , Xu Wenfang
Published: December 2009

The key precursor for the synthesis of novel influenza neuraminidase inhibitors, cis-4-azido-L-proline methyl ester hydrochloride (C6H11ClN4O2, Mr = 206.63), was prepared as white needle-shaped crystals and its structure was elucidated by single-crystal X-ray diffraction. In the crystal structure, molecules are linked through intermolecular hydrogen bonds, forming layers perpendicular to the bc plane.
Microwave-assisted synthesis of 1,3,4-thiadiazole aroylurea derivatives
Authors: Han Feng , Wan Rong , Wang Peng , Wang Yao , Wang Jintang
Published: December 2009

A rapid and efficient microwave-assisted synthesis method for the preparation of 1-aroyl-3-(5-aryl-1,3,4-thiadiazol-2-yl)urea is described. These 1,3,4-thiadiazole aroylureas (5a–f) were identified by IR, 1H NMR, elemental analyses and N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-ylcarbamoyl]-2,6-difluorobenzamide was confirmed by single-crystal X-ray diffraction. The target compounds were prepared under microwave in a shorter reaction time compared with conventional heating methods.
One pot synthesis of 1,3,4-thiadiazole thiazolidinone derivatives
Authors: Wang Peng , Wan Rong , Han Fen , Wang Yao
Published: December 2009

One pot synthesis of 2-(substitutedphenyl)-3-[5-(substitutedphenyl)-1,3,4-thiadiazol-2-yl]thiazolidin-4-one was developed by the reaction of 1,3,4-thiadiazole, substituted benzaldehyde and mercaptoacetic acid. These compounds were identified by IR, 1H NMR, elemental analyses and 2-(4-methoxyphenyl)-3-[5-(3-methylphenyl)-1,3,4-thiadiazol-2-yl]thiazolidin-4-one was confirmed by single-crystal X-ray diffraction.
Simple and efficient colourimetric F- sensors and a test paper for fluorine
Authors: Wei Tai-Bao , Li Yan , Lin Qi , Zhang You-Ming
Published: December 2009

A series of colourimetric fluoride ion sensors bearing azo-phenolic hydroxyl and Schiff base groups were synthesised. In CH3CN solutions, these sensors showed colourimetric single selectivity for F-. An easy-to-prepare test paper based on the sensor was developed, which could colourimetrically conveniently detect fluoride ion.
Oxidation of alkyl benzenes to corresponding carbonyl compounds with 1,4-dichloro-1,4-diazoniabicyclo [2,2,2] octane bis-chloride in water
Authors: Habibzadeh Setareh , Tajbakhsh Mahmood
Published: December 2009

The 1,4-dichloro-1,4-diazoniabicyclo [2,2,2] octane bis-chloride oxidation of various alkylbenzenes gives the corresponding carbonyl compounds in water as solvent.
One-pot three component reaction for the synthesis of chromone-linked naphthopyrans
Authors: Panja Suman Kalyan , Maiti Sourav , Bandyopadhyay Chandrakanta
Published: December 2009

Heating an equimolar mixture of 6-substituted chromone-3-carbaldehydes, β-naphthol and dimedone in AcOH produces 3,3-dimethyl-11-(4-oxo-4 H-1-benzopyran-3-yl)-1,2,3,4-tetrahydronaphtho[2,1- b]-1-benzopyran-11 H-1-ones, whereas under similar condition use of Meldrum's acid in place of dimedone gave 1 -benzopyrano[2,3- b]naphtho[1,2- e] pyran-7a H, 13 H-13-ones and 3,4-dihydro-4-(4-oxo-4 H-1-benzopyran-3-yl)naphtho[2,1- b]pyran-2 H-2-ones.
A Novel 2-D 5d-4f-3d Trimetal-Isonicotinic Acid Complex: Synthesis and Characterisation
Authors: Chen Wentong , Ying Shaoming , Liu Dongsheng , Liu Jiuhui
Published: December 2009

A novel trimetallic–isonicotinic acid complex [Zn0.5(H2O)]{(Hg2Cl5)[Eu(C6NO2H4)3(H2O)2]}(HgCl2)·H2O (1) has been synthesised and structurally characterised by single-crystal X-ray diffraction. Complex 1 features a novel 2-D {(Hg2Cl5)[Eu(C6NO2H4)3(H2O)2]} layer constructed from [Eu(C6NO2H4)3(H2O)2] chains interconnected by Hg2Cl5- linkers. The 2-D {(Hg2Cl5)[Eu(C6NO2H4)3(H2O)2]} layers are held together via hydrogen bonds and π–π interactions to yield a 3-D supramolecular framework with the lattice water molecules, the mercury chloride and the hydrated zinc ions located in the cavities.
Electrogenerated base promoted synthesis of N-substituted-4-hydroxy-4-methylthiazolidine-2-thione derivatives
Authors: Tissaoui Khalil , Raouafi Noureddine , Boujlel Khaled
Published: December 2009

Electrochemically-generated basic species from the reduction of acetonitrile assisted the condensation of carbon disulfide, primary arylmethylamines and chloroacetone to yield the corresponding N-substituted-4-hydroxy-4-methylthiazolidine-2-thione derivatives. In some cases, dehydration reaction led to the N-substituted-4-methylthiazole-2(3 H)-thione analogues. The effect of the electrogenerated base amount on the reaction yield was also studied.
Raney Ni–Al alloy-mediated reduction of alkylated phenols in water
Authors: Tan Song-Liang , Liu Guo-Bin , Gao Xiang , Thiemann Thies
Published: December 2009

Raney Ni–Al alloy in a dilute aqueous alkaline solution has been shown to be a very powerful reducing agent in the hydrogenation of phenol and alkylated phenols to the corresponding cyclohexanol derivatives.
Microwave-assisted one-pot synthesis of a, β-unsaturated amides under solvent-free conditions
Authors: Jiang Shilei , Xie Yuanyuan , Yu Xiaochun
Published: December 2009

Under microwave-assisted solvent-free conditions a one-pot reaction of triphenylphosphine, an aldehyde and N, N-diethyl chloroacetamide in the presence of zinc dust affords α, β-unsaturated amides stereoselectively in good yield. In comparison with the conventional heating method, the reaction was finished within five minutes under microwave irradiation.
Synthesis of novel silyl enol ethers from chlorodimethyl(naphthylphenylmethyl)silanes having a chiral centre and a ketone and their chirality transfer effects in crossed-aldol reactions
Authors: Miyakawa Kenichi , Konakahara Takeo , Sakai Norio , Kozawa Kozo , Gunji Takahiro , Nagao Yukinori
Published: December 2009

X-ray crystallography was used to determine the stereo structure of a novel chiral organosilicon compound, (2 R)-(–)-(1-cyclohexenyloxy)dimethyl(1-naphthylphenylmethyl) silane, which has a chiral centre next to the silicon atom. The crossed-aldol reaction of the silyl enol ether with benzaldehyde gave the corresponding aldol products with high chirality transfer.
Heteroannulation of chromene derivatives. Synthesis of chromeno[4,3-e] indazolone chromeno[4,3-f]quinazoline and pyrano[3,2-c]chromene derivatives
Authors: Mahmoud Mahmoud R. , El-Bassiouny Fakhry A. , Azab Mohamed E. , El-Kady Mohamed Y. , Rashed Hesham M.
Published: December 2009

Pentane-2,4-dione and 3-ethoxycarbonylcoumarin react in the presence of sodium ethoxide to form 10-acetyl-7,9-dihydroxy-6 H-benzo[ c]chromen-6-one (2). Compound 2 reacted with aromatic aldehydes and ethyl cyanoacetate to give the chromeno-chromenediones 3 and 4 respectively, with hydrazine hydrate to form the azine 5, with phenyl hydrazine giving the chromeno-indazole 6, with primary amines to form the imines 7a–f, and with thiourea to give the chromeno-quinazoline 8. Methyl 2-amino-4-(4-methoxyphenyl)-5-oxo-4,5-dihydro-pyrano[3,2- c]chromene-3-carboxylate (9a) and the corresponding 3-carbonitrile 9b were prepared, and the reactions of the ester 9a with phenacyl chloride, furoyl chloride, and hydrazine hydrate were investigated.
Diterpenoids from Isodon excisoides
Authors: Zhang Ji Xia , Wang Yong Xue , He Zhi An , Yan Fu Lin
Published: December 2009

Two new ent-kaurane diterpenoids taihangexcisoidesin A and B (1 and 2), together with 10 known diterpenoids, were isolated from the EtOAc extract of the leaves of Isodon excisoides. Their structures were determined on the basis of spectroscopic methods.
Synthesis and binding properties of two new fluorescent molecular clips based on diethoxycarbonyl glycoluril
Authors: Sheng-Li Hu , Shuai Wang , Yi-Tao Li , Li-Ping Cao , An-Xin Wu
Published: December 2009

Two new fluorescent molecular clips based on diethoxycarbonylglycoluril have been synthesised and their binding properties investigated by fluorescence spectroscopy to show that they can selectively bind Fe3+ with fluorescence quenching.
Rapid microwave-promoted solvent-free synthesis of hypervalent iodine reagents
Authors: Zhou Zhongshi , He Xuehan
Published: December 2009

Hypervalent hydroxy(sulfonyloxy)iodoarenes, hydroxy(phosphoryloxy)iodoarenes and bis(trifluoroactoxy)iodo-benzene have been synthesised by a fast and convenient solvent-free ligand exchange reaction from the (diacetoxyiodo)arene under microwave irradiation, providing a simple method for the synthesis of these hypervalent iodine reagents in good yield and in a short time.
Synthesis and Spectral Properties of 2,7-di-tert-butyl-4,9-bis(arylethynyl)-and 4,10-bis(arylethynyl)pyrenes
Authors: Hu Jian-yong , Paudel Arjun , Yamato Takehiko
Published: December 2009

Formylation of 2,7-di- tert-butylpyrene with dichloromethyl methyl ether in the presense of AlCl3 afforded a mixture of 2,7-di- tert-butylpyrene-4,9-biscarbaldehyde and 4,10-biscarbaldehyde in the ratio of 75:25, from which the corresponding bis(arylethynyl)pyrenes were obtained by the Wittig reaction with aryl methyl phosphonium ylides followed by bromination and dehydrobromination.
Arylation of 3-heterylmethylene-5-arylfuran-2(3H)-thiones
Authors: Abou-Elmagd Wael S.I. , Hashem Ahmed I.
Published: December 2009

The behaviour of 3-heterylmethylene-5-arylfuran-2(3 H)-thiones towards the Lewis acid AlCl3 under Friedel–Crafts reaction conditions compared with their oxygen analogues, the furan-2(3 H)-ones is studied. Although the later are known to undergo alkyl/oxygen ring cleavage to give resonance stabilised carbocations which can exhibit either intra- or intermolecular alkylations, furanthiones gave 1, 4-adducts with the furan ring remaining intact. This difference in behaviour is explained in terms of both electronic and steric effects.
Microwave Activation of Alumina and its use as a Catalyst in Synthetic Reactions
Authors: Dadush Eric , Green James F. , Sease Aaron , Naravane Abhijit , Pagni Richard M. , Kabalka George W.
Published: December 2009

Microwave irradiation is a simple and efficient method of activating gamma alumina. Alumina activated in this manner is an excellent medium in which to carry out the Diels–Alder reaction and, in conjunction with additional microwave irradiation, the Claisen rearrangement. Several 2-allylphenols formed in the Claisen rearrangement rapidly undergo ring closure on alumina to form dihydrobenzofurans demonstrating the Brønsted acidity of the solid.
Oxidation of Arylaminomagnesium Compounds by Copper Salts
Authors: Zhang Ming , Zhang Rongli , Zhang Ai-Qin , Zhao Yongli , Wang Tao
Published: December 2009

Oxidation of arylaminomagnesium compounds by cupric chloride has been investigated. A possible oxidation reaction mechanism is considered.
Synthesis of Substituted Quinolines from Arylamines and Aldehydes via Tandem Reaction Promoted by Chlorotrimethylsilane
Authors: Bian Xiaoqin , Liu Lanhai , Geng Xin , Xie Zengyang , Li Shuangshuang , Wang Cunde
Published: December 2009

Substituted quinolines were effectively synthesised by utilising chlorotrimethylsilane (TMSCl) as an efficient catalyst in the cyclisation condensation of aromatic amines and enolisable aldehydes via a tandem process in air and DMSO. The clean, mild reaction conditions, operational simplicity and high yields were attractive features of the reaction which enables a facile preparative procedure for building the quinoline ring.
Synthesis and Structure of Novel 1,2,4-triazole Derivatives Containing the 2,4-dinitrophenylthio Group
Authors: Ding Qichun , Lei Xinxiang , Jin Jianyu , Zhang Lixue , Du Huiai , Zhang Haile
Published: December 2009

Some novel 1,2,4-triazole derivatives containing the 2,4-dinitrophenylthio group have been synthesised in high yields by means of the reactions of 3-substituted-4-amino −1 H-1,2,4-triazole-5(4 H)-thiones or ( E)-3-aryl-4-(benzylideneamino)-1 H-1,2,4-triazole-5(4 H)-thiones with 1-chloro-2,4-dinitrobenzene. The ( E)-3-aryl-4-(benzylideneamino)-1 H-1,2,4-triazole-5(4 H)-thiones were prepared by the reaction of 4-amino-3-aryl-2 H-1,2,4-triazole-3(4 H)-thiones and diverse aromatic aldehydes. The 2, 4-dinitrophenyl group linked to the S atom, not to the N atom, was confirmed by the crystal structures. The structures of all the compounds were determined by elemental analysis, IR, MS, 1H NMR and 13C NMR.
New Functionalised C,C-pyridylpyrazoles: Synthesis and Cation Binding Properties
Authors: Radi Smaail , Attayibat Ahmed , Ramdani Abdelkrim , Bacquet Maryse
Published: December 2009

The synthesis of two new C,C-pyridylpyrazole isomers with a functionalised arm is described. The complexation capabilities of these ligands compared to their homologues towards bivalent metals (Hg2+, Cd2+, Pb2+, Cu2+, Zn2+) and alkali metal ions (K+, Na+, Li+) were investigated using a liquid–liquid extraction process. The percentage limits of extraction were determined by atomic absorption measurements.
Four-Component Reaction of cyclohexyl isocyanide, acetylenic esters, carboxylic acids and pyrrole. Synthesis of dialkyl 2-alkanoyloxy (or benzoyloxy)-3-[cyclohexylimino(1H-pyrrol-2-yl)methyl]succinates
Authors: Anary-Abbasinejad Mohammad , Anaraki-Ardakani Hossain
Published: December 2009

An improved four-component reaction of isocyanides is described. The reaction between cyclohexyl isocyanide, dialkyl acetylenedicarboxylates, carboxylic acids and pyrrole in dichloromethane at room temperature leads to 2-alkanoyloxy (or benzoyloxy)-3-[cyclohexylamino(1 H-pyrrol-2-yl)methyl]succinates in good yields.
A Green Efficient Synthesis of spiro[indoline-3,4′(1H‘)-pyrano [2,3-c]pyrazol]-2-one derivatives
Authors: Liu Ying , Zhou Dong , Ren Zhongjiao , Cao Weiguo , Chen Jie , Deng Hongmei , Gu Qing
Published: December 2009

A highly efficient and green method has been described for the synthesis of spiropyranopyrazole-oxindole in water. The reaction was carried out at ambient temperature and the products were obtained in excellent isolated yields. The structure of the product (4e) was confirmed by X-ray diffraction analysis.
Debromocymopolone from the Green Alga, Cymopolia Barbata
Authors: Gallimore Winklet A. , Sambo Tandose , Campbell Theresa
Published: December 2009

Investigation of a Jamaican green alga, Cymopolia barbata led to the isolation of a new geranyl-1,4-dihydroxybenzene, debromocymopolone, the structure of which was elucidated by spectroscopic techniques.
Two New Glyceroglycolipids from the Fruits of Cucurbita Moschata
Authors: Jiang Zhi-Guo , Dua Qi-Zhen
Published: December 2009

A phytochemical study of Cucurbita moschata resulted in the characterisation of two new glyceroglycolipids, 1-O-(9 Z, 12 Z,15Z-octadecatrienoyl)-3-a[β-D-galactopyranosyl-(1→6)-0-β-D-galactopyranosyl-(1→6)- O-β-D-galactopyranosyl] glycerol (1) and 1- O-(9 Z,12 Z-octadecadienoyl)-3- O-[β-D-galactopyranosyl-(1→6)- O-β-D-galactopyranosyl-(1→6)- O-β-D-galactopyranosyl] glycerol (2). Their structures were elucidated on the basis of spectroscopic analysis especially 2D-NMR (TOCSY, HMQC, HMBC, and NOESY) combined with chemical method.
Conversion of 3-Arylphthalides into Anthrones with a Methylcarbonyl Substituent at the C-10 Position
Authors: Bieniek Adam , Bartczak Monika M. , Epsztajn Jan
Published: December 2009

The ortho-lithiation of a benzoic acid anilide followed by condensation with an aryl aldehyde gave a 3-arylphthalide. Reductive alkylation with 1-methoxy-1-trimethylsilyloxyethene gave a substituted aromatic carboxylic acid which was cyclised to an anthrone bearing a methoxycarbonyl methylene unit at C-10.
Synthesis of 1,5-benzothiazepines with Microwave Irradiation under Solvent and Catalyst-free Conditions
Authors: Rahman M. , Roy A. , Majee A. , Hajra A.
Published: December 2009

Microwave irradiation of α,β-p-unsaturated ketones (chalcones) and o-aminothiophenol in the absence of solvent and catalyst provides a highly efficient methodology for the synthesis of 1,5-benzothiazepines in moderate to good yields.
The Cyclisation of 2′-aminochalcones using Silica-Supported Yb(OTf)3 under Solvent-free Conditions
Authors: Li Jianjun , Jin Linyong , Yu Chuanming , Su Weike
Published: December 2009

Silica-supported Yb(OTf)3 is utilised as a catalyst for the synthesis of 2-substituted dihydroquinolinones from 2′-amino chalcones in good yields. The catalyst is easily prepared and is active under solvent-free conditions and environmentally friendly conditions.
Synthesis and Langmuir Monolayer Characterisation of Some Nitro Derivatives of Polyphenyl Carboxylic Acids
Authors: Dynarowicz-Łątka Patrycja , Milart Piotr
Published: December 2009

Derivatives of 5′-phenyl-1,1′:3′,1″-terphenyl-4-carboxylic acid (PTCA), each with 4′-nitro-substituents (2 and 5) have been synthesised and characterised as Langmuir monolayers at the air/water interface. Surface pressure and electric surface potential measurements of the monolayers under a variety of experimental conditions have been made. The presence of the nitro-substituent (in 2 cf 2′) was found to change the sign of the measured surface potential, indicating that the nitro-derivative is oriented with the -NO2 group towards the air side, while the carboxylic group is anchored into the water subphase. Upon introducing two more side phenyl groups into the hydrophobic core of the nitro derivative 2 to give 5, the measured surface potential (and the resulting apparent dipole moment) change sign to positive, indicating the prevalence of the dipolar contribution from the hydrophobic moiety over that of the hydrophilic part of the molecule. Our results show that the contribution of the double layer potential arising from ionisation of the carboxylic group of the investigated molecules is | 0.1 | V.
Ultrasound-assisted Wittig Reaction and Synthesis of 5-alkyl- and 5-alkenyl-resorcinols
Authors: Wu Li-Qiang , Yang Chun-Guang , Yang Li-Ming , Yang Li-Juan
Published: December 2009

Some 5-alkyl- and 5-alkenyl-resorcinols were synthesised from commercially available 3,5-bis(benzyloxy)benzaldehyde by ultrasound-assisted Wittig reaction with alkyltriphenyl phosphonium bromides in basic aqueous condition, followed by debenzylation and simultaneously reduction of a double bond of the styrene type with Na/n-BuOH in overall yields of 62–72%.
Novel Synthesis of 6,12-dihydroindolo[3,2-b]carbazoles catalysed by p-toluenesulfonic acid
Authors: Jin Can , Zhang Bo , Yu Chuanming , Su Weike
Published: December 2009

An efficient and straightforward procedure for the synthesis of 6,12-dihydroindolo[3,2- b]carbazoles has been achieved through the one-pot reaction of indole with aromatic aldehydes in the presence of p-toluenesulfonic acid ( pTSA) as the catalyst.
Determination and Evaluation of the Second-Order Rate Constants for the Oxidation of Maleic and Fumaric Acid Derivatives with Alkaline Potassium Permanganate
Authors: Halim S. Rahimah Abdul , French Gilly M. , Hughes Alexandra J.N. , Smith C.A. Olivia Prankerd , Hughes D.E. Peter
Published: December 2009

The second-order rate constants for the oxidation of maleic ( Z-butenedioc) and fumaric ( E-butenedioc) acid derivatives by potassium permanganate at pH 13 were determined. These constants varied by a factor of 104. The results suggested that the rates of attack of the permanganate ion on the double bonds were largely governed by steric factors with electrostatic and electronic effects playing only a minor role.
Synthesis, Spectroscopic and Crystal Structure Analysis of Two Dihydropyrimidines
Authors: Begum Noor Shahina , Vasundhara D.E.
Published: December 2009

The preparation of two reduced pyrimidine derivatives, ethyl 3-acetyl-4-(4-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate and ethyl 4-(3,4-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylate, is described, along with details of their crystal structure analysis.
Ferric Hydrogensulfate as a Recyclable Catalyst for the Synthesis of Some New bis(indolyl)methane Derivatives
Authors: Rahimizadeh Mohammad , Eshghi Hossein , Bakhtiarpoor Zahra , Pordel Mehdi
Published: December 2009

New bis(indolyl)methanes were synthesised in excellent yields by the reaction of indole derivatives with aromatic and aliphatic aldehydes in the presence of ferric hydrogensulfate as an efficient, inexpensive, heterogeneous, reusable and non-toxic catalyst.
Synthesis and Cytotoxicity of Novel 3-amido-4-indolylmaleimide Derivatives
Authors: Zhao Sheng Yin , Mou Shi Wei , Chen Zhi Long , Yue Yun , Sun Yun
Published: December 2009

A series of novel 3-amido-4-indolylmaleimides have been synthesised from succinimide in five steps sequence consisting of bromination, indole addition, azide substitution, reduction and selective acylation. Cytotoxicity was evaluated for the products against cervical cancer Hela cell lines and human hepatocellular cancer SMMC 7721 cell line by standard MTT assay in vitro. Some of these compounds showed moderate cytotoxic potencies.
Synthesis and Characterisation of 2,3a,5,6,7a-pentaacetoxy-octahydro-1H-indene from indan-2-ol
Authors: Balci Neslihan , Kelebekli Latif , Goksu Suleyman , Anil Baris , Sahin Ertan
Published: December 2009

A synthesis of 2,3a,5,6,7a-pentaacetoxyoctahydro-1 H-indene has been achieved starting from indan-2-ol. The Birch reduction of indan-2-ol gave 4,7-dihydro-2-indanol in high yield which when followed by acetylation, resulted in the corresponding acetates. The OsO4 oxidation of the 2-acetoxy-4,7-dihydroindane followed by acetylation furnished the desired pentaacetates in high yield.
Methylation of Phenolic Hydroxyl Group and Demethylation of Anisoles
Authors: Sato Nobuhiro , Endo Hiroyuki
Published: December 2009

A mild methylation of phenolic hydroxyl groups with iodomethane was enabled in the presence of sodium bis(trimethylsilyl)amide at room temperature. The reverse reaction, namely demethylation of methyl phenyl ethers, was easily achieved by microwave heating with neat iodotrimethylsilane.
Synthesis and Characterisation of 2,3,4a,6,8a-penta-acetoxy decahydronaphthalene from 1,2,3,4-tetrahydronaphthalen-2-ol
Authors: Oztaskin Necla , Kelebekli Latif , Goksu Suleyman , Anil Baris , Sahin Ertan
Published: December 2009

2,3,4a,6,8a-Penta-acetoxy decahydronaphthalene has been synthesised starting from 1,2,3,4-tetrahydronaphthalen-2-ol. The Birch reduction of 1,2,3,4-tetrahydronaphthalen-2-ol gave a high yield of 1,2,3,4,5,8-hexahydronaphthalen-2-ol which was acetylated. The OsO4 oxidation of the 1,2,3,4,5,8-hexahydronaphthalen-2-yl acetate followed by further acetylation gave the pentaacetates.
A Route to a Tetrabenzothiazole from Michael Bis-Addition Compounds
Authors: Wang Guowei , Zhuang Linghua , Wang Jintang
Published: December 2009

An efficient and practical synthesis of a tetrabenzothiazole has been developed by condensation of Michael bis-adducts with 2-aminothiophenol.
Preparation and Reactions of 2-azidoquinoline-3-carboxaldehyde with Primary Amines and Active Methylene Compounds
Authors: Ibrahim Nabila M. , Yosef Hisham Abdallah A. , Mahran Mohamed Refat H.
Published: December 2009

Preparation of 2-azidoquinoline-3-carboxaldehyde has been attempted and its tautomerism has been discussed. The reactivity of 2-azidoquinoline-3-carboxaldehyde towards primary amines, hydrazines and active methylene compounds has been investigated. Analytical and spectroscopic measurements have assisted the assignment of appropriate structures to the new reaction products.
Synthesis of Symmetrical Bisamides by Reaction between Aromatic Aldehydes and Alkyl Nitriles in the Presence of Chlorosulfonic Acid
Authors: Anary-Abbasinejad Mohammad , Mosslemin Mohammad H. , Hassanabadi Alireza
Published: December 2009

Reaction between aromatic aldehydes and alkyl nitriles in the presence of chlorosulfonic acid leads to N-[alkanoylamino-(aryl)-methyl]- amide derivatives in excellent yields.
Facile Synthesis of 1H, 4H-cyclopenta[c]pyrrolo[1,2-b]isoquinolin-2(3H)-one
Authors: Sun Mo Ran , Lu Hong Tao , Yang Hua
Published: December 2009

A novel and facile method for the synthesis of 4H-cyclopenta[c]pyrrolo[1,2-b] isoquinolin-2(3H)-one has been developed by employing the [2, 3] Stevens rearrangement of methyl N-allyl-N-benzylpyrrolidine 2-carboxylate to methyl 2-allyl-l-benzyl-pyrrolidine 2-carboxylate and acid-lactonisation as key transformations. The synthetic strategy from readily available materials provided a model skeletal analogue of cephalotaxine and should have general applicability in the synthesis of Cephalotaxus alkaloids.
Regio-Controlled Michaelis-Arbuzov Reactions of 3-(halomethyl)-coumarins
Authors: Rashamuse Thompo J. , Musa Musiliyu A. , Klein Rosalyn , Kaye Perry T.
Published: December 2009

3-(Iodomethyl)coumarins and 3-(chloromethyl)coumarins, obtained chemoselectively via Baylis–Hillman reactions of salicylaldehyde derivatives with t-butyl acrylate, can be reacted with triethyl phosphite to afford regioisomeric Michaelis-Arbuzov products. Under nitrogen, the 3-(iodomethyl)coumarins undergo direct displacement of iodide to afford the expected 1′-phosphonated derivatives. The reactions with 3-(chloromethyl)coumarins in air, however, proceed with overall allylic rearrangement to afford the regioisomeric 3-methyl-4-phosphonated derivatives.
Chemistry of Phosphorus Ylides. Part 27. Metal Complexes of 4-hydroxyquinaldine, its Mannich Base and Phosphonium Ylide
Authors: Soliman Fouad , Abd-Ellah Ibrahim , Maigali Soher , Abd-El-Naim Gamal
Published: December 2009

The reaction of Hg2+,Cd2+,Co2+, and Ni2+ ions with 1 mol of the ligands 2-methylquinoline-4-ol,3[(diethylamino)methyl]-2-methylquinoline-4-ol, and methyl-3-(4-hyrdoxy-2-methylquinoline-3-yl)-2-(triphenylphosphoranylidene)propanoate, has been investigated to give the corresponding 1:1 metal:ligand complexes. Reaction of 2 mol of the ligand gave the corresponding 1:2 metal:ligand complexes. The coordination takes place only through the quinoline nitrogen atom. The spectroscopic and the physicochemical data of the new metal complexes are discussed.
Stereochemistry of Products of Reactions between 3-diazo-naphthalene-1,2,4-trione and β-dicarbonyl Compounds. Structure of ethyl 2-[(3-hydroxy-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)-hydrazono]-3-phenyl-3-oxo-propionate
Authors: da Silva Fernando de C. , Ferreira Vitor F. , Lopes Patrícia de O. , Wardell James L. , Wardell Solange M. S. V.
Published: December 2009

3-Hydroxy-2-[(R1CO)(R2CO)]C=NNH-1,4-naphthoquinones, obtained from reactions of 3-diazonaphthalene-1,2,4-trione with β-diketones, R1C(O)CH2COR2, have been previously found to have high antibacterial activity. However, confirmation of the stereochemistry about the C=N bond could not be achieved by spectroscopic means for products having different R1 and R2 groups, thereby limiting the utility of the reaction. Full characterisation of the product isolated from reaction of 3-diazonaphthalene-1,2,4-trione with PhC(O)CH2CO2Et is now reported, from a single crystal X-ray structure determination: the product, 3-hydroxy-2-[(PhCO)(EtCO2)]C=NNH-1,4-naphthoquinone has a ( Z)-stereochemistry. The Z-isomer is obtained rather than the E form due to the preferred formation of the stronger intramolecular N–H—O hydrogen-bond with the ester carbonyl oxygen rather than a weaker one with the ketone oxygen. Weaker C–H—O hydrogen bonds link the molecules into columns. It is suggested that similar Z geometries will arise from other RC(O)CH2CO2Ri reactants.
Synthesis and anti-bacterial screening of ethyl 6-oxo-3-phenyl-1,6-dihydropyrano[3,2-e]indole-2-carboxylate and 7-phenyl-5H-pyrano [3′,2′:4,5]indolo[1,2-a]quinoxaline-6,10-dione
Authors: Mir Abid Ali , Mulwad Vinata V.
Published: December 2009

Ethyl 6-oxo-3-phenyl-1,6-dihydropyrano[3,2- e]indole-2-carboxylate 3a-c were synthesised from ethyl 2-[(2-oxo-2 H-1-benzopyran-6-yl)-hydrazono]-3-phenylpropanoate 2a-c. Compounds 2a-c was in turn prepared by reacting diasotised solution of 6-aminocoumarin and ethyl-2-benzylacetoacetate. N-nitroarylation of ethyl 6-oxo-3-phenyl-1,6-dihydropyrano[3,2- e]indole-2-carboxylate 3a-c was carried out with 2-chloronitrobenzene to give ethyl 1-(2-nitrophenyl)-6-oxo-3-phenyl-1,6-dihydropyrano[3,2- e]indole-2-carboxylate 4a-c, which on catalytic reductive cyclisation with H2/Ni affords 7-phenyl-5 H-pyrano[3′,2′:4,5]indolo[1,2- a]quinoxaline-6,10-dione 5a-c. The structures of all these compounds have been established on the basis of analytical and spectral data. All the compounds show significant antibacterial activity.
A New Diarylheptanoid from the Bark of Myrica Nana
Authors: Zeng Lingjie , Chen Lihua , Liu Linsheng
Published: December 2009

A new diarylheptanoid, 3,5-dimethoxyl-17-hydroxyl-4,19-diketo-11-ene-[7,0]metacyclophane, named as nanaone, was isolated from the bark of Myrica nana along with six known compounds. Their structures were elucidated by various spectroscopic methods including 2D-NMR techniques or comparison with authentic samples.
Synthesis of perialkynylated tetrapyrazinoporphyrazines and its Optical Properties
Authors: Jang Chun Keun , Jaung Jae Yun
Published: December 2009

Some phthalocyanines soluble in organic solvents have been developed by peripheral introduction of substituent groups. We report a new method for preparation of the polyphenyl-substituted dicyanopyrazines based on the [2 + 4] Diels-Alder cycloaddition of the tetraphenylcyclopentadienone to an ethynyl compound. The synthesised tetrapyrazinoporphyrazinato metal complexes were characterised by UV-visible spectroscopy, MALDI-TOF-Ms (matrix-assisted laser desorption ionisation time-of-flight mass) spectroscopy, and 1H NMR spectroscopy.
Stereoselective synthesis of 3-[2-(dialkoxyphosphoryl)-1,2-dialkoxycarbonyl-ethyl]-4-hydroxycoumarins by reaction between trialkyl phosphites, dialkyl acetylenedicarboxylates and 4-hydroxycoumarin
Authors: Anary-Abbasinejad Mohammad , Charkhati Khadijeh , Hassanabadi Alireza
Published: December 2009

A three-component reaction between trialkyl phosphites, dialkyl acetylenedicarboxylates and 4-hydroxycoumarin is described as a simple and efficient route for the synthesis of 3-[2-(dialkoxyphosphoryl)-1,2-dialkoxycarbonyl-ethyl]-4-hydroxycoumarins in high yields.
Anticancer Activities of bis(pyrazol-1-ylthiocarbonyl)disulfides against HeLa cells
Authors: Keter Frankline K. , Nell Margo J. , Guzei Ilia A. , Omondi Bernard , Darkwa James
Published: December 2009

Oxidation of the pyrazol-1-yldithiocarbamate compounds {[3,5-R2C3HN2CS2]- (R = H, Me} and indazol-1-lydithiocarbamate by iodine produces the sulfur-sulfur coupling compounds {R'C(S)S-S(S)CR'} (R’ = pyrazolyl, 3,5-dimethylpyrazolyl, indazolyl). All compounds were spectroscopically characterised, and, in some cases, structurally characterised. The X-ray structures reveal that these compounds contain a disulfide bridging the pyrazolylthiocarbonyl units. Two of the three disulfide compounds showed very good anticancer activities against HeLa cells at micromolar concentrations, with the most active compound active being 9.6 times more selective in its activity towards tumour cells than normal cells.
Vicinal Benzo[b]thiophene-5,6-dicarboxaldehyde in Heterocyclic Synthesis: A Reagent for Fluorescence Determination of Amino Acids
Authors: El-Borai Mohamed A. , Rizk Hala F.
Published: December 2009

Benzo[ b]thiophene-5,6-dicarboxaldehyde reacts with dibenzyl ketone, thiodiacetic acid dimethyl ester, hydrazine, p-toluidine, p-aminoacetophenone and nitromethane to give the corresponding seven, six and five-membered rings condensed to benzo[ b]thiophene. Reaction of benzo[ b]thiophene-5,6-dicarboxaldehyde with p-toluidine in the presence of 2-mercaptoethanol gives highly fluorescent compounds. Also, benzo[ b]thiophene-5,6-dicarboxaldehyde was applied to fluorogenic reaction with some amino acids and the obtained data were compared with the reported data in the case of o-phthaldehyde. The synthesised compounds were characterised by their elemental analysis, IR, 1H NMR and mass spectrometry
Synthesis and Studies of Hydrolysis of p-nitrophenyl picolinate catalysed by Schiff base zinc (II) complexes with aza-crown ether or morpholino-pendants
Authors: Feng Xue-song , Tang Ying , Li Jian-zhang , Zhang Jin , Qin Sheng-ying
Published: December 2009

Four Schiff base zinc (II) complexes with either benzo-10-aza-crown ether pendants or morpholino-pendants have been synthesised and employed as models for hydrolase enzymes by studying the kinetics of their hydrolysis reactions with p-nitrophenyl picolinate (PNPP). A kinetic model of PNPP cleavage catalysed by these complexes is proposed. The effects of complex structures and reaction temperature on the rate of catalytic PNPP hydrolysis have been also examined. The rate increases with pH of the buffer solution; all four complexes exhibited high activity in the catalytic PNPP hydrolysis. Compared with their crown-free analogues, the crowned Schiff base complexes exhibit higher catalytic activity. The catalytic activity of a phenyl-bridged Schiff base complex is larger than that of an ethyl-bridged Schiff base complex under the same substitute groups and metal ion.
Synthesis, Characterisation and Photophysical Properties of α,β-diaryl-acrylonitrile Derivatives
Authors: Yue Youfeng , Fang Haiyan , Wang Meijun , Wang Zhiyuan , Yu Mingxin
Published: December 2009

α,β-Diarylacrylonitrile derivatives can be prepared by two different routes: (1) the intermolecular condensation of the same arylacetonitriles (2) the condensation of arylaldehydes and arylacetonitriles with a catalytic amount of NaOCH3 at room temperature. Several α,β-diarylacrylonitrile derivatives have been synthesised in this paper and characterised. The UV-vis absorption and photoluminescent (PL) spectra of the products were investigated.
Synthesis of a Series of perfluoroalkyl containing spiro cyclic barbituric acid derivatives
Authors: Zhang Shunli , Shi Zhijian , Cao Weiguo , Gao Tianyun , Deng Hongmei
Published: December 2009

An efficient and versatile method for the preparation of a series of perfluoroalkyl containing spiro cyclic barbituric acid derivatives is described. 7,9-Dimethyl-2-(iodomethyl)-3-(perfluoroalkylmethyl) 7,9-diazaspiro[4.5]decane-6,8,10-trione were prepared in good yields from 1,3-dimethylbarbituric acid. The structures of these compounds were confirmed by 1H NMR, 13C NMR, IR, MS spectra and elemental analysis.
The Structure of the Colourant/Pigment, Carmine Derived from Carminic Acid
Authors: Harris Michael , Stein Bridget K. , Tyman John H.P. , Williams Christopher M.
Published: December 2009

The colourant/pigment carmine synthesised from carminic acid and calcium and aluminium acetates has been examined chemically and spectroscopically to determine its structure. As with alizarin, it appears probable that the material is a tetramer but composed of four carminic acid units with aluminium involved with the 5,6-dioxy groups in five-membered rings and calcium chelated with the 10-carbonyl group of the anthraquinone system.
Synthesis of homoallylic alcohols by allylation of aldehydes and ketones catalysed by a mesoporous material (MCM-41)-supported cyano palladium complex
Authors: Yao Fang , Huang Bin , Cai Mingzhong
Published: December 2009

A variety of homoallylic alcohols has been conveniently synthesised in good to high yields by the allylation of aldehydes and ketones with allylic chlorides catalysed by an MCM-41-supported cyano palladium complex in DMF using SnCl2 as reducing agent. This polymeric palladium complex can be recovered and reused with some loss of activity.
Ervahainanmine, a new indole alkaloid from the stems of Ervatamia hainanensis
Authors: Zhan Zha-Jun , Zhang Li-Wen , Shan Wei-Guang
Published: December 2009

A new sarpagine-type alkaloid with N-oxide group, called ervahainanmine, and three known ones including coronaridine, 19(S)-heyneanineguan, and coronaridine hydroxyindolenineguan were isolated from the stems of Evratamia hainanensis. The structure was established by spectroscopic methods, especially 2D NMR techniques.
Synthesis and Photophysical Properties of Conjugated Quinolines
Authors: Yue Youfeng , Yu Mingxin , Zhu Longguan
Published: December 2009

Aryl halides were prepared by condensation of 2-methylquinoline and bromo- or chloro-arylaldehydes in acetic anhydride. Diarylamines reacted with the aryl halides to afford novel triarylamine derivatives using Pd(OAc)2/P ( o-tolyl)3 as catalyst. These compounds have potential as organic light-emitting device materials and were characterised by FT-IR, 1H NMR and elemental analyses. The UV-vis absorption and photoluminescent spectra of the compounds in CH2CI2 were investigated. The lowest absorption band of the triarylamine derivatives centred at about 400 nm was assigned to a charge-transfer transition with an emission at 500–515 nm.
Iron-catalysed Sonogashira Reactions
Authors: Pan Changduo , Luo Fang , Wang Wenhui , Ye Zhishi , Liu Miaochang
Published: December 2009

A catalytic system has been developed that used an iron/ligand combination for the Sonogashira cross coupling of terminal alkynes with aryl iodides, which affords products in good to excellent yields.
Synthesis, crystal structure, binding properies of a noncyclic crown-type receptor derived from diethoxycarbonyl glycoluril
Authors: Bao-Han Zhou , Li-Ping Cao , An-Xin Wu
Published: December 2009

A novel noncyclic crown-type diethoxycarbonyl glycoluril derivative receptor was synthesised and its crystal structure was obtained. The study of its binding behaviour towards neutral guests showed that it can bind hydroquinone, resorcinol and catechol.
Synthesis, spectral characterisation and anti-microbial activity of novel 3-substituted-2, 4-dihydro-12H-3λ5-tribenzo [f, j, n] [1, 5, 9,12, 3] dioxadiazaphosphacyclopentadecine-3-selones
Authors: Reddy S. Subba , Rao V. Koteswara , Dadapeer E. , Raju C. Naga
Published: December 2009

Tris(bromomethyl)phosphineoxide and 2-[(2-[( Z)-1-(2-hydroxyphenyl)methylidene]aminophenyl)imino]methylphenol have been utilised as precursors in the synthesis of novel pentaco-ordinate dioxadiazaphosphacyclopentadecines[e.g. 3-[(2-hydroxyethoxy)methyl]-2,4-dihydro-12 H-3λ5-tribenzo[ f, j, n][1,5,9,12,3]dioxadiazaphosphacyclopentadecine-3-selone] in moderate (overall) yields. The synthesised compounds were characterised by elemental and spectral (IR, 1H, 13C, 31P NMR and MS) studies and their anti-microbial activity was evaluated.
Synthesis, Structure and Property of a Metal sulfochloride–Hg3S2CI2
Authors: Chen Hua-Long , Kuang Han-Mao , Chen Wen-Tong , Ying Shao-Ming , Liu Jiu-Hui
Published: December 2009

The compound [Hg3S2CI2] has been obtained by solid-state reactions. It crystallises in the acentric space group R3 of the rhombohedral system with six formula units in a cell [ a = b = 12.654(3), c = 7.753(4) Å, V = 1075.1(6) Å3, CI2Hg3S2, M r = 736.79, D c = 6.828 g cm−3, S = 0.987, μ(Mo Kα) = 65.308 mm−1, F(000) = 1836, R = 0.0631 and wR = 0.1443] and is characterised by a 3-D framework structure, which is composed of interconnected right-handed helices formed by tetrahedral Hg atoms. Optical absorption spectra reveal the presence of an optical bandgap of 2.51 eV and the composition Hg3S2CI2 is confirmed by semiquantitative microscope analysis.