bluuebunny/crossref_metadata_2025 huggingface dataset:
دور الوسطية في وحدة الأمة الإسلامية
Authors: Hoque Mesbahul , Abd Kadir Kauthar , Mohamed Yuslina , Abdul Rab Muneer Ali
Published: October 2023

الوسطيّة هي وسيلة هامّة لوحدة هذه الأمّة وسلامتها وأمنها من التفرقة والتشرذم، حيث إن الفكرة الوسطيّة هي التي تضمن وحدة الأطراف المتنازعة وجمعهم على صعيد واحد، كما أن الوسطيّة تنقذ الأمّة من الوقوع في براثن الكفر والتكفير والضلال. وأيّ جنوح عن الوسطية سيؤدي بصاحبه إلى الإفراط أو التفريط، وكلا هما سبب من أسباب تفرق الأمة وتشتتها، وضياع أمنها وسلامتها، ولذا وصف الله سبحانه الوسطية كسمة لهذه الأمة، حيث قال الله تعالى: ﴿ وَكَذَلِكَ جَعَلْنَاكُمْ أُمَّةً وَسَطًا لِتَكُونُوا شُهَدَاءَ عَلَى النَّاسِ وَيَكُونَ الرَّسُولُ عَلَيْكُمْ شَهِيدًا ﴾ [البقرة: 143]، ويأتي هذا البحث ليلقي الضوء على الوسطية وتأثيرها على وحدة الأمة  باستخدام بعض المناهج المناسبة لها كالمنهج الوصفي والاستقرائي والتحليلي، ومن أهم نتائج البحث أن الوسطية لها مفهوم واسع في الإسلام، وهي معيار وحدة الأمة وسفينة أمنها من الهلاك.
Moderation is a means for the unity, safety and security of this Ummah from division and fragmentation, as the moderate idea is what guarantees the unity of the conflicting parties and their gathering on one level. Moderation saves also the Ummah from falling into the clutches of infidelity, blasphemy and misguidance. Any deviation from moderation will lead the person to excessiveness or negligence, both of which are among the causes of the Ummah’s disunity and dispersal, and the loss of its security and safety. Therefore, Allah S. W.T describe the moderation as a characteristic of this Ummah, as Allah S.W.T said: “And thus, we have made you a middle nation so that you may be witnesses over people and that the Messenger will be witnesses for you” (Al-Baqarah:143). This study comes to shed light on moderation and its impact on the unity and integrity of the Ummah by using some appropriate approaches to it, such as the descriptive, inductive and analytical method. One of the most important results of the study is that moderation has a broad concept in Islam, and it is the criterion of the nation’s unity and its safety ship from destruction.
Effect of refraction and field of view of acrylic viewports of shallow water spherical pressure hull
Authors: Pranesh Bhaskaran , Sathianarayanan Dharmaraj
Published: October 2023

A shallow water spherical hull for manned submersible has been designed and developed by National Institute of Ocean Technology, India. During the design phase, a detailed study was carried out concerning the conical acrylic viewports, to understand the limit of aperture, field of view through viewports, field of view of seafloor, and reflection. It is also important to understand the effect of refraction due to acrylic and sea water, which is significant for making engineering judgements while collecting samples from the seabed. This study recommends having larger diameter viewports and larger angles between the primary and secondary viewports. A limitation would be that increasing the diameter of the viewport would increase the size of the viewport flange.
Highlights

The layout of the observation windows, field of view, field of view of the sea floor, and refraction effects are studied
Effect of refraction due to acrylic and sea water, which is significant for making engineering judgements while collecting samples from the seabed
The distortion depends on the viewing angle, thickness of the viewport window, and object distance inside the sea water
Minimum overlapping regions in the fields of view of viewports need to be maintained so that two crews can see the objects together which fall in the common field of view
PENGGUNAAN VIDEO DALAM PENGAJARAN DAN PEMBELAJARAN PENDIDIKAN MORAL TINGKATAN 2 [USAGE OF VIDEO IN TEACHING AND LEARNING IN MORAL EDUCATION FORM 2]
Authors: YAHYA SA’ADATUL FARHANA , OTHMAN MUHAMMAD ATIULLAH
Published: October 2023

This study was conducted to overview the usage of video in the teaching and learning of form 2 moral education. The objective of the first study was to examine the implementation of video usage activities in the classroom while the second objective is to examine the effectiveness of video usage activities to attract students and the third objective is to study the use of video shows bynhancing students' understanding. The study methodology is inquiry research which used interview methods for six respondents who had undertaken teaching and learning activities using video presentation method. The analysis of the data was done qualitatively based on the answers given by the respondents. The findings show that teaching and learning using video can increase interest, attitude and prominent understanding in Moral Education among students in schools. Most teachers are able to guide students to think and master knowledge through contextual experience, developing skills to collect, process, and analyse data and information and even inculcate noble values.
INTERDISCIPLINARIDADE E A TEORIA GERAL DOS SISTEMAS
Authors: Colossi Nelson , Baade Joel Haroldo
Published: October 2023

Resumo: Esta reflexão tem por objetivo resgatar a origem e o significado da Teoria Geral dos Sistemas, no âmbito das ciências em geral, particularmente no campo das ciências sociais e no estudo da Teoria das Organizações, ressaltando, por fim, a congruência desse desenvolvimento com o movimento interdisciplinar nas ciências. Pode ser caracterizado como histórico-interpretativo, cujo objetivo é apresentar origens e desenvolvimento de um fenômeno e, assim, oferecer noções e ideias para posicionamentos futuros sobre o tema. Conclui-se que a TGS, que expressivamente influenciou e ainda influencia a Teoria das Organizações, é uma possibilidade de resgate da interdisciplinaridade inerente aos fenômenos próprios do comportamento humano, também no âmbito organizacional.Palavras-Chave: Interdisciplinaridade. Teoria Geral dos Sistemas. Teorias das Organizações. Liderança.INTERDISCIPLINARITY AND GENERAL THEORY OF SYSTEMSAbstract: This reflection aims to rescue the origin and meaning of General Systems Theory, in the context of science in general, particularly in the social sciences and the study of Organizational Theory, pointing out, finally, the congruence of this development with the movement interdisciplinary sciences. It can be characterized as historical and interpretive, whose goal is to present the origins and development of a phenomenon and thus offer notions and ideas for future positions on the subject. It follows that the General Systems Theory, which significantly influenced and still influences the Theory of Organizations, is a possibility of redemption of the inherent interdisciplinarity to the very phenomena of human behavior, also at the organizational level.Keywords: Interdisciplinarity. General Systems Theory. Organizational theories. Leadership.
Development of an English module based on Bugis' local wisdom
Authors: Mujahidah  , Hidayat Wahyu , Dj Muhammad Zuhri , Ishak
Published: October 2023

This study aims at developing high school English learning modules based on Bugis culture. This research applied Development Design Research (DDR) approach and involved several parties related to the development of the EMBOS module, namely high school English teachers and experts. Data were collected by using Focus Group Discussion. The data were analyzed qualitatively using the N-VIVO software, and the quantitative data were analyzed using the Fuzzy Delphi and Aiken's V methods. Needs analysis using the Group Interview method or Focus Group Discussion resulted in several issues or themes. The results of expert approval using the Fuzzy Delphi method found that the Mappadendang topic received approval in the song/narrative material with a Threshold (d) value of 0.038 and an average of Fuzzy Number 0.787. The topic of Mappadinding received approval on the Explanation Text/ Description Text material with a Threshold (d) value of 0.038 and an average fuzzy number of 0.787. Nene Malomo's topic on Traditional Story/Narrative Text/Reading Comprehension material with a Threshold (d) value of 0.038 and an average of Fuzzy Number 0.787. Developing an English learning module based on Bugis Local Wisdom consists of the beginning, content and the end. Experts have validated the EMBOS module. The results of expert validation indicate that this module is generally suitable for use in learning English at the high school level or equivalent. An English learning module based on Bugis local wisdom can be implemented as an alternative to bring students closer to their environment or contextual learning.
Prototipe Otomatisasi dan Pemantauan Sistem Hidroponik Berbasis IoT dengan Pemanfaatan Solar Panel Sebagai Sumber Energi
Authors: Erlangga Apta Prana Mas , Dinatha Ketut Saha Kesta , Nainggolan Frisca Elfrisa , Prayogi Soni
Published: October 2023

Penelitian ini menghadirkan sebuah prototipe otomatisasi dan pemantauan sistem hidroponik berbasis Internet of Things (IoT) yang dioptimalkan dengan pemanfaatan panel surya sebagai sumber energi. Sistem ini dirancang untuk meningkatkan efisiensi pertanian hidroponik modern dengan memantau dan mengontrol parameter lingkungan seperti tingkat kelembaban, suhu, pH, dan pencahayaan tanaman secara real-time. Panel surya digunakan untuk menyediakan sumber energi berkelanjutan, menjadikan sistem ini ramah lingkungan dan otonom. Prototipe ini terhubung ke platform IoT yang memungkinkan pengguna untuk mengakses dan mengontrol sistem melalui aplikasi ponsel pintar atau komputer. Selain itu, data lingkungan yang terkumpul dapat dianalisis untuk meningkatkan hasil pertanian dan meminimalkan konsumsi sumber daya. Penelitian ini mewakili langkah penting dalam menggabungkan teknologi IoT dan energi terbarukan untuk meningkatkan produktivitas pertanian modern dengan cara yang berkelanjutan dan efisien.
Enhancing UI/UX of The Smart Village System Website Using User-Centered Design Methods
Authors: Wijaya Alek , Azhiman Fauzan
Published: October 2023

The Smart Village System is a platform specifically designed to help publicize village potential. Of course, it is very important to test UI/UX on sidespin websites which are still very far from perfect, so it becomes a question of whether the UI/UX sidespin is in line with the expectations of the community as the target user. This study intends to design UI/UX on sidespin websites by utilizing the UCD method which aims to improve interface quality, efficiency, and productivity as well as community satisfaction. The UI/UX design on this sidespin website uses the UCD method because several stages involve establishing a relationship and interaction between users. 5 people are willing to become User Personas who can provide input on user satisfaction which will be evaluated using a Heuristic Evaluation which will be combined with Survey Ratings. The results of this study state that all aspects of the satisfaction level of the User Persona are in the satisfied category. Recommendations were found to be developed by the Smart Village System Team, among others, in terms of the principles of Heuristic Evaluation 4, 5, and 6. Consistency and Standards have restructured sentences and are consistent from one page to another. Error Prevention has added many features to the sidespin and finally, Recognition rather than recall has implemented local and rural nuances on the page sidespin.
Effectiveness of Using MIT App Inventor as an Android-Based Learning Media
Authors: Jannah Miftahul , Khairunnisa Khairunnisa , Lorosae Teguh Ansyor , Ramadhan Sahrul
Published: October 2023

Massive updates on technology make teachers have to be more extra in determining the learning materials and media used. The technology used must be up-to-date and provide good results as a learning medium that must be used. Technological developments must truly be transferable as learning media, given that Revolution 5.0 is targeting innovation and development in more sophisticated technologies such as AI, IoT, and robots. Humans can slowly be replaced with machines and everything may be computerized. By being given knowledge from now on, at least students have provisions for the future. The process of transferring knowledge is not only done by speaking in front of the class, the process also requires media or intermediaries to bridge it so that the process of transferring knowledge becomes more optimal and faster. The use of appropriate learning media can certainly make students better understand what is being taught. On this basis, the purpose of this study was to determine the effectiveness of using Mit App Inventor as a learning medium. The method used is Descriptive Quantitative. Data collection was carried out by distributing questionnaires to students of SMK 1 Muhammadiyah Bima who had used Mit App Inventor in their learning process. The results of this study indicate that the use of Mit App Inventor at SMK 1 Muhammadiyah Bima is effective. The first indicator "Platform Quality" gets a percentage of 88.5%, the second indicator "Student Understanding" gets a percentage of 93.9%, the third indicator gets a percentage of "Student Preference" 81.2% and the fourth indicator "Benefits Obtained" gets a percentage 80.3%. It can be said that Mit App Inventor is of good quality, easy to understand, and provides good benefits for the learning process.
Machine Learning-Based Classification for Scholarship Selection
Authors: Asriyanik Asriyanik , Pambudi Agung
Published: October 2023

University of Muhammadiyah Sukabumi (UMMI) is a university that accepts KIP scholarship every year. However, KIP student applicants always exceed the quota, so it requires a re-selection process to determine KIP Shcolarship Awardee. UMMI does not have a clear method to support decisions in the selection process for KIP Shcholarship Awardee. To solve this problem, a classification modeling process will be carried out from previous data using machine learning algorithms, namely with Decision Tree (DT) and Support Vector Machine (SVM) algorithms. The general method for its development uses the SEMMA method (Sample, Explore, Modify, Model, Assess). Starting with collecting a dataset of KIP recipients studying at UMMI from 2021-2022 which amounted to 519 data with 16 attributes. From the results of exploration, the main attributes that became features for modeling were DTKS Status, P3KE Status, Combined income of father and mother and achievement. These attributes are converted into numeric data for easy data modeling. The results of K-Fold Cross-Validation for the DT model in the case of classification of KIP Kuliah recipients resulted in an accuracy of 78.44% of the entire test dataset, a precision of 0.73107 indicating that 73.11% of the model's predictions were correct, recall (sensitivity level) of 78.45% and an F1 score of 73.20%. The results of modeling and validation with SVM are 80.17% accuracy, 84.44% precision and 80.17% recall. The SVM model shows slightly better in terms of accuracy and precision, both models show competitive performance in classifying KIP scholarship recipients studying at UMMI.
Optimization of Village Budget Plan Selection Based on Priorities Using Method Promethee and Borda
Authors: Laily Dwi Yanti , Dedi Irawan Muhammad
Published: October 2023

The rapid information technology that is happening now

has a significant impact on human life, including various

activities that occur at the village office. The village head

is responsible for managing funds at the village level

including the collection and accountability of funds in

accordance with the provisions of law no.33 of 2004

concerning the balance of central and regional

governments. This study aims to implement a decision

support system by combining two methods, namely the

promethee and borda methods in selecting village budget

plans in Tegal Sari village based on priority. The method

used in this research is the Research and Development

(R&D) method. The method used for calculations is the

PROMETHEE and Borda methods. The PROMETHEE

method is used to manage individual decisions from each

decision maker, while the Borda method is used to

manage group decisions resulting from the PROMETHEE

ranking method. The criteria in this study are Cost,

Completion Time, Impact on Regions/Society, Profits

from Sustainable Investment, Factors of Interest. The

results obtained from this research are Pemb. Health

Sarpras as an alternative priority for the village budget.
Regionális különbségek alakulása Magyarországon – kapcsolódási pontok a gazdasági teljesítménnyel és a kereskedelmi tendenciákkal
Authors: Dobó Róbert , Pintér Tibor
Published: October 2023

A tanulmány legfőbb célkitűzése, hogy kimutassa hogyan alakultak 2000 és 2021 között a regionális különbségek Magyarországon. Ehhez a szakirodalomban fellelhető legfontosabb mutatókat alkalmazzák a szerzők: Hoover-index, súlyozott relatív szórás és Theil-index. Az volt a kezdeti feltételezésünk, hogy az egyenlőtlenségek fokozódása és kiegyenlítődése bizonyos korszakokban váltotta egymást, ezt a mutatók eredményei vissza is igazolják. Mindezek mellett azt vizsgáltuk még munkánk során, hogy a területi kiegyenlítődés folyamata vélelmezhetően milyen kapcsolatban van Magyarország nemzetgazdasági, külgazdasági teljesítményével? Ehhez a térséghez viszonyított relatív gazdasági növekedési rés, valamint a kereskedelmi arány és a külkereskedelmi egyenleg mutatóit vettük figyelembe. Azt mutatják eredményeink, hogy a relatíve kedvezőtlen nemzetgazdasági teljesítmény és a relatíve magasabb külkereskedelmi mérleghiány negatív hatást gyakorolt a területi kiegyenlítődésre. A regionális különbségek alakulása és a nemzetgazdasági teljesítmény közötti összefüggések természetesen összetettek és változóak lehetnek. Általában azonban a fejlettebb régiókban magasabb a GDP és az életszínvonal, mint a kevésbé fejlett régiókban. A külkereskedelmi mérleg egyenlege a gyakorlatban szintén befolyásolhatja a regionális különbségeket, mivel a gazdasági tevékenység különböző formái eltérő mértékben függenek a külkereskedelmi áramlásoktól. A gazdaságokban tapasztalható kereslet- és kínálati tényezők változása és az árszintek is befolyásolhatják a kereskedelem és a gazdasági tevékenység eloszlását a régiók között. Általános következtetésként magállapítható, hogy a kedvező nemzetközi kereskedelmi feltételek elősegíthetik a régiók közötti egyenlőbb fejlődést, míg az ezzel ellentétes tendenciák gátolják a gazdasági konvergenciát.
DNA CODES FROM REVERSIBLE GROUP CODES BY A VIRUS OPTIMISATION ALGORITHM
Authors: KORBAN Adrian , ŞAHİNKAYA Serap , ÜSTÜN Deniz
Published: October 2023

In this paper, we employ group rings and some known results on group codes to study reversible group DNA codes. We define and study reversible cyclic DNA codes from a group ring point of view and we also introduce the notion for self-reciprocal group ring elements. Moreover, we search for reversible group DNA codes with the use of a virus optimisation algorithm. We obtain many good DNA codes that satisfy the Hamming distance, the reverse, the reverse-complement and the fixed GC-content constraints.
Analisis Keberpihakan dan Framming Pemberitaan Kecurangan Pilpres 2019 Pada Media Detik.com
Authors: Raihan Muhammad
Published: October 2023

Pemberitaan kecurangan pilpres 2019 oleh Detik.com mengalami pembingkaian akibat adanya keberpihakan terhadap kubu BPN Prabowo pada pilpres 2019. Pemberitaan kecurangan pilpres 2019 oleh Detik.com lebih banyak dibandingkan dengan media Suara.com, Gelora.co, Kontan.co.id, dan Republika.co.id. Penelitian ini betujuan untuk membahas keberpihakan media Detik.com dalam framing pemberitaan kecurangan pilpres 2019. Penelitian ini menggunakan teori framing dan konsep keberpihakan media. Metode yang digunakan adalah kualitatif deskriptif dengan menggunakan sumber data primer dan data sekunder. Penelitian ini menggunakan paradigma kritis untuk melihat fakta, posisi media, ideologi, pandangan media yang terlibat dalam teks berita, kepentingan pemilik terhadap konten berita. Teknik pengambilan sampel dilakukan dengan melakukan wawancara, bahan dokumentasi, dan studi pustaka. Penulis menggunakan empat tahapan analisis data framing berita menurut William A. Gamson, yaitu penggunaan kalimat mencolok, perincian informasi tertentu, kata atau istilah tertentu, dan visualisasi gambar. Hasil akhir penelitian ini menunjukan media Detik.com berusaha menyangkal kalau berpihak terhadap kubu BPN Prabowo, namun pada kenyataannya pemilik media yaitu Chairul Tanjung memiliki kepentingan pragmatis, keterkaitan ideologi pemilik media, kepentingan politik pemilik media, kepentingan ekonomi pemilik media, posisi kepemilikan media yang dekat dengan capres Prabowo oleh Chairul Tanjung yang mempengaruhi wartawan maupun reporter dalam proses pembuatan berita dan mempengaruhi terhadap hasil liputan terhadap framing pemberitaan kecurangan pilpres 2019 yang lebih cenderung terhadap kubu BPN Prabowo guna memenangkan Prabowo sebagai presiden yang diusung oleh koalisi BPN Prabowo. Penelitian ini menyimpulkan bahwa pemilik media memiliki pengaruh dalam memutuskan berita yang penting diberitakan kepada masyarakat
Implementasi Program Tenaga Kerja Mandiri (TKM) Dalam Mengurangi Pengangguran Di Wilayah Jakarta Utara
Authors: Rahayu Erina Latri , Firman Firman
Published: October 2023

Tulisan ini bertujuan untuk menganalisis Implementasi Program Tenaga Kerja Mandiri (TKM) Dalam Mengurangi Pengangguran Di Jakarta Utara. Pengangguran merupakan masalah sosial yang serius di Wilayah Jakarta Utara. Untuk mengatasi permasalahan ini, pemerintah telah meluncurkan program tenaga kerja mandiri yang bertujuan untuk memberdayakan masyarakat dengan keterampilan dan pengetahuan yang diperlukan untuk memulai usaha sendiri. Implementasi program ini melibatkan sejumlah langkah strategis yang ditujukan untuk meningkatkan peluang kerja dan mengurangi tingkat pengangguran. Metode penelitian yang di gunakan adalah deskript kualitatif dengan teknik pengumpulan datanya yaitu wawancara, dokumentasi dan observasi. Program Ini berfokus pada penelitian dan keterampilan. Peserta program diberikan pelatihan dalam berbagai bidang seperti bidang kue, tata rias, service ac dan menjait. Dengan keterampilan yang ditingkatkan, akan membantu peserta akan membantu mereka dalam mencari peluang kera yang lebih baik. Program ini juga menciptakan jembatan antara usaha mandiri dengan perusahaan yang membutuhkan layanan atau produk tertentu. Dengan kolaborasi semacam ini, para peserta program memiliki kesempatan untuk memperluas jangkauan pasar mereka. Program ini dapat menyediakan bantuan keuangan berupa pinjaman dengan suku bunga rendah atau hibah modal usaha bagi peserta yang telah menyelesaikan pelatihan dan memiliki rencana bisnis. Bantuan keuangan ini membantu mereka memulai bisnis tanpa hambatan besar. Kemudian program ini menyediakan bantuan fasilitas untuk memulai usaha mandiri. Program ini juga melibatkan pembinaan dan pendampingan usaha. Peserta program didampingi pendamping dari Suku Dinas Tenaga Kerja Transmigrasi dan Energi, yang membantu mereka menghadapi tantangan dan memberikan saran untuk mengembangkan bisnis mereka secara berkelanjutan. Program ini dapat memberikan kontribusi signifikan dalam meningkatkan kesempatan kerja, mengurangi pengangguran, dan meningkatkan kesejahteraan masyarakat di wilayah tersebut
IDEA TESTING AND ANALOGY PREDICT CREATIVITY OF BIOLOGY STUDENTS IN ONLINE LEARNING
Authors: Diki  , Vi Sara Dem , Yuliastuti Endah Sulistyawati Eko , Dwisatyadini Mutimanda
Published: October 2023

Identifying factors affecting students’ success is important. This is a study on creativity of biology students to solve their learning problem. The participants are biology students at Universitas Terbuka (UT), the only single mode distance learning university in Indonesia.  conducting online tutorial in introductory biology. Descriptive and bivariate correlation statistics data are collected, including one dependent variable about improvement of problem-solving skill and six independent variables. The six independent variables are problem identification, information searching, idea generation, analogy, integrating different concepts, and idea testing. Demographic data are age, gender, and length of daily online activities. There are 73 students returned the survey with 23.4% response rate. Most students (more than 60%) agree to some extent in all the variables. There are different levels of agreement about the use of online tutorial regarding gender, age and length of daily online activities. There are only two out of six independent variables that have significant correlation (0.05 significance level, two-tailed) with improvement of problem-solving skill, which are analogy and idea testing.

Keywords: creativity, biology, problem-solving, distance learning, online learning
Försörjningsstöd är inte förtidspension
Authors: Thorson Jan
Published: October 2023

Egenförsörjning av klienter med försörjningsstöd är en utmaning för kommunerna, särskilt socialtjänsten. Sjuka eller störda och arbetsoförmögna klienter intar ofta och länge en odefinierad position. Personlighetsvariationer, psykisk sjukdom av oklar eller sammansatt natur, men även neurologisk diagnos, kan innebära lång tid med försörjningsstöd, trots arbetsoförmåga eller avsaknad av anställningsbarhet. Den socialmedicinska vardagen för tanken till Inghes arbete om fattiga i folkhemmet (1958), och Grunewalds kamp för rättvis omsorg om förståndshandikappade, bl a att de fick rätt till sina egna pengar, ekar i korridorerna (2008). Motsvarande insats för arbetsoförmögna sjuka, som under senare år beviljats försörjningsstöd, är sjukersättning. Sådan fordrar samarbete mellan vården, socialtjänsten och Försäkringskassan. Lagarna, Socialförsäkringsbalken (SFB) (SFS 2010:110) och Socialtjänstlagen (SoL) (SFS 2001:453) främst, med prejudikat är fundamentet. Och det duger.
Lyrik: Olle Jilkén
Authors: Jilkén Olle
Published: October 2023

Jilkén doktorerar inom företagsekonomi på sektionen för management, organisation och samhälle vid Stockholms universitet. Jilkén har en kandidatexamen i företagsekonomi med inriktning konst och kultur samt en masterexamen i genusvetenskap. Jilkéns aktuella avhandlingsprojekt undersöker svensk mångfalds- och inkluderingsarbete utefter emotionssociologiska teorier.
Factors and co-factors influencing clinical manifestations in nsLTPs allergy: between the good and the bad
Authors: Ridolo Erminia , Barone Alessandro , Ottoni Martina , Peveri Silvia , Montagni Marcello , Nicoletta Francesca
Published: October 2023

Non-specific lipid transfer proteins (nsLTPs) are a family of plant pan-allergens that represent the primary cause of food allergies in the Mediterranean area, characterized by a wide range of clinical manifestations, ranging from the total absence of symptoms up to anaphylaxis. This wide variety of symptoms is related to the intrinsic capacity of nsLTPs to cause an allergic reaction in a specific subject, but also to the presence of co-factors exacerbating (i.e., exercise, NSAIDs, PPIs, alcohol, cannabis, prolonged fasting, menstruation, acute infections, sleep deprivation, chronic urticaria) or protecting from (i.e., co-sensitization to PR10, profilin or polcalcin) severe reactions. In this picture, recognizing some nsLTPs-related peculiarities (i.e., route, type and number of sensitizations, concentration of the allergen, cross-reactions) and eventual co-factors may help the allergist to define the risk profile of the single patient, in order to promote the appropriate management of the allergy from dietary advices up to the prescription of life-saving epinephrine autoinjector.
Real flue gas CO2 hydrogenation to formate by an enzymatic reactor using O2- and CO-tolerant hydrogenase and formate dehydrogenase
Authors: Cha Jaehyun , Lee Jinhee , Jeon Byoung Wook , Kim Yong Hwan , Kwon Inchan
Published: October 2023

It is challenging to capture carbon dioxide (CO2), a major greenhouse gas in the atmosphere, due to its high chemical stability. One potential practical solution to eliminate CO2 is to convert CO2 into formate using hydrogen (H2) (CO2 hydrogenation), which can be accomplished with inexpensive hydrogen from sustainable sources. While industrial flue gas could provide an adequate source of hydrogen, a suitable catalyst is needed that can tolerate other gas components, such as carbon monoxide (CO) and oxygen (O2), potential inhibitors. Our proposed CO2 hydrogenation system uses the hydrogenase derived from Ralstonia eutropha H16 (ReSH) and formate dehydrogenase derived from Methylobacterium extorquens AM1 (MeFDH1). Both enzymes are tolerant to CO and O2, which are typical inhibitors of metalloenzymes found in flue gas. We have successfully demonstrated that combining ReSH- and MeFDH1-immobilized resins can convert H2 and CO2 in real flue gas to formate via a nicotinamide adenine dinucleotide-dependent cascade reaction. We anticipated that this enzyme system would enable the utilization of diverse H2 and CO2 sources, including waste gases, biomass, and gasified plastics.
The AMPK-like protein kinases Sik2 and Sik3 interact with Hipk and induce synergistic tumorigenesis in a Drosophila cancer model
Authors: Yu Kewei , Ramkumar Niveditha , Wong Kenneth Kin Lam , Tettweiler Gritta , Verheyen Esther M.
Published: October 2023

Homeodomain-interacting protein kinases (Hipks) regulate cell proliferation, apoptosis, and tissue development. Overexpression of Hipk in Drosophila causes tumorigenic phenotypes in larval imaginal discs. We find that depletion of Salt-inducible kinases Sik2 or Sik3 can suppress Hipk-induced overgrowth. Furthermore, co-expression of constitutively active forms of Sik2 or Sik3 with Hipk caused significant tissue hyperplasia and tissue distortion, indicating that both Sik2 and Sik3 can synergize with Hipk to promote tumorous phenotypes, accompanied by elevated dMyc, Armadillo/β-catenin, and the Yorkie target gene expanded. Larvae expressing these hyperplastic growths also display an extended larval phase, characteristic of other Drosophila tumour models. Examination of total protein levels from fly tissues showed that Hipk proteins were reduced when Siks were depleted through RNAi, suggesting that Siks may regulate Hipk protein stability and/or activity. Conversely, expression of constitutively active Siks with Hipk leads to increased Hipk protein levels. Furthermore, Hipk can interact with Sik2 and Sik3 by co-immunoprecipitation. Co-expression of both proteins leads to a mobility shift of Hipk protein, suggesting it is post-translationally modified. In summary, our research demonstrates a novel function of Siks in synergizing with Hipk to promote tumour growth.
The effect of Toll-like receptor agonists on the immunogenicity of MVA-SARS-2-S vaccine after intranasal administration in mice
Authors: Do Kim Thi Hoang , Willenzon Stefanie , Ristenpart Jasmin , Janssen Anika , Volz Asisa , Sutter Gerd , Förster Reinhold , Bošnjak Berislav
Published: October 2023

Background and aims

Modified Vaccinia virus Ankara (MVA) represents a promising vaccine vector for respiratory administration to induce protective lung immunity including tertiary lymphoid structure, the bronchus-associated lymphoid tissue (BALT). However, MVA expressing the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike protein (MVA-SARS-2-S) required prime-boost administration to induce high titers of anti-Spike antibodies in serum and bronchoalveolar lavage (BAL). As the addition of adjuvants enables efficient tailoring of the immune responses even to live vaccines, we tested whether Toll-like receptor (TLR)-agonists affect immune responses induced by a single dose of intranasally applied MVA-SARS-2-S.

Methods

We intranasally immunized C57BL/6 mice with MVA-SARS-2-S vaccine in the presence of either TLR3 agonist polyinosinic polycytidylic acid [poly(I:C)], TLR4 agonist bacterial lipopolysaccharide (LPS) from Escherichia coli, or TLR9 agonist CpG oligodeoxynucleotide (CpG ODN) 1826. At different time-points after immunization, we analyzed induced immune responses using flow cytometry, immunofluorescent microscopy, and ELISA.

Results

TLR agonists had profound effects on MVA-SARS-2-S-induced immune responses. At day 1 post intranasal application, the TLR4 agonist significantly affected MVA-induced activation of dendritic cells (DCs) within the draining bronchial lymph nodes, increasing the ratio of CD11b+CD86+ to CD103+CD86+ DCs. Nevertheless, the number of Spike-specific CD8+ T cells within the lungs at day 12 after vaccination was increased in mice that received MVA-SARS-2-S co-administered with TLR3 but not TLR4 agonists. TLR9 agonist did neither significantly affect MVA-induced DC activation nor the induction of Spike-specific CD8+ T cells but reduced both number and size of bronchus-associated lymphoid tissue. Surprisingly, the addition of all TLR agonists failed to boost the levels of Spike-specific antibodies in serum and bronchoalveolar lavage.

Conclusions

Our study indicates a potential role of TLR-agonists as a tool to modulate immune responses to live vector vaccines. Particularly TLR3 agonists hold a promise to potentiate MVA-induced cellular immune responses. On the other hand, additional research is necessary to identify optimal combinations of agonists that could enhance MVA-induced humoral responses.
Genetic relatedness of Tunisian Sign Language and French Sign Language
Authors: Nefaa Aymen
Published: October 2023

This article constitutes the first cognate study aiming at the verification of the genetic link between LSF (French Sign Language) and LST (Tunisian Sign Language) through a lexicostatistical analysis of both sign languages (SLs). To do this, an orthographic/graphic 100 basic lexical items list was utilized to elicit LST lexical items from Tunisian deaf signers with a mean age of 20.86 from three different governorates in the country (Tunis, Nabeul, and Douz). The lists were then compared to LSF lexical signs from two LSF dictionaries (Elix and IVT). Results of the lexicostatistical analysis between the varieties of LST in the three governorates and LSF suggest a proposed distant genetic relationship between the two SLs.
Epicardial fat volume, an independent risk factor for major adverse cardiovascular events, had an incremental prognostic value to myocardial perfusion imaging in Chinese populations with suspected or known coronary artery disease with a normal left ventricular ejection fraction
Authors: Yang Le , Yu Wenji , Wan Peng , Wang JingWen , Shao Xiaoliang , Zhang Feifei , Yang Xiaoyu , Chen Yongjun , Li Qi , Jiang Dan , Wang Yufeng , Jiang Qi , Wang Jianfeng , Wang Yuetao
Published: October 2023

Background

Most coronary artery disease (CAD) patients with a normal left ventricular ejection fraction (LVEF) experience a poor prognosis. Single-photon emission computerized tomography (SPECT)–myocardial perfusion imaging (MPI), a routine examination, is useful in assessing risk and predicting major adverse cardiovascular events (MACEs) in populations with suspected or known CAD. SPECT/CT is a “one-stop shop” examination, which, through non-contrast CT, can produce attenuation correction for MPI and obtain information on coronary artery calcium (CAC) and epicardial fat volume (EFV) simultaneously. This study aims to investigate the predictive and incremental value of EFV to MPI for MACE in Chinese populations with suspected or known CAD with a normal LVEF.

Methods and results

We retrospectively studied 290 suspected or known CAD inpatients with a normal LVEF who underwent SPECT/CT between February 2014 and December 2017. Abnormal MPI was defined as a summed stress score ≥4 or summed difference score ≥2. EFV and CAC were calculated using non-contrast CT. The end date of follow-ups was in February 2022. The follow-up information was obtained from the clinical case notes of the patients or reviews of telephone calls. MACE was defined as cardiac death, late coronary revascularization ≥3 months after MPI, non-fatal myocardial infarction, angina-related rehospitalization, heart failure, and stroke. During the 76-month follow-up, the event rate was 32.0% (93/290). Univariate and multivariate Cox regression analyses concluded that high EFV (>108.3 cm3) [hazard ratio (HR): 3.3, 95% CI: 2.1–5.2, P < 0.000] and abnormal MPI (HR: 1.8, 95% CI: 1.1–2.8, P = 0.010) were independent risk factors for MACE. The event-free survival of patients with high EFV was significantly lower than that of the low EFV group (log-rank test P < 0.001). In the subgroup with normal MPI, high EFV was associated with reduced event-free survival (log-rank P < 0.01), with a higher annualized event rate (8.3% vs. 1.9%). Adding high EFV to MPI could predict MACEs more effectively, with a higher concordance index (0.56–0.69, P < 0.01), higher global chi square (7.2–41.4, P < 0.01), positive integrated discrimination improvement (0.10, P < 0.01), and net reclassification index (0.37, P < 0.01).

Conclusions

In Chinese populations with suspected or known CAD with normal LVEF, high EFV was an independent risk factor for MACE after adjusting for traditional risk factors, CAC and MPI. In subgroups with normal MPI, EFV could also improve risk stratification. Adding EFV to MPI had an incremental value for predicting MACE.
Association of serum 25-hydroxyvitamin D concentrations with all-cause mortality among individuals with kidney stone disease: the NHANES database prospective cohort study
Authors: Gao Meng , Liu Minghui , Chen Jinbo , Zhu Zewu , Chen Hequn
Published: October 2023

Background

The purpose of this study was to investigate the correlation between serum 25(OH)D concentrations and all-cause mortality in patients with kidney stone disease (KSD) as the effects of a deficiency in 25-hydroxyvitamin D on KSD patients are currently unclear.

Methods

For our prospective cohort study, we included 2,916 participants from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. The National Death Index (NDI) was utilized to identify all causes of death and cause-specific mortality until December 31, 2018. We calculated hazard ratios (HR) and 95% confidence intervals (CIs) using multivariate Cox regression models.

Results

During the 18,859 person-years of follow-up, a total of 375 fatalities occurred, including 83 deaths from cardiovascular disease (CVD) and 79 deaths from cancer. At baseline, individuals with higher blood 25(OH)D concentrations had lower levels of glucose, glycohemoglobin, CRP, and insulin, as well as higher levels of HDL cholesterol (P < 0.01). In the fully adjusted model (Model 3), compared to the group with the lowest 25(OH)D concentrations, those with serum 25(OH)D concentrations ≥75 nmol/L had hazard ratios (HRs) and 95% confidence intervals (CIs) of 0.48 (0.26, 0.87) for all-cause mortality (P=0.02, P for trend = 0.02). The association between serum 25(OH)D concentrations and all-cause mortality in KSD patients was found to be significantly non-linear. A 7% decrease in the risk of death from all causes was observed for each unit-nmol/L increase in serum 25(OH)D concentrations when the concentrations were below 27.7 nmol/L (P < 0.05).

Conclusion

Based on the findings, KSD patients with insufficient serum 25(OH)D concentrations were at a higher risk of all-cause mortality. Therefore, it is crucial to maintain sufficient blood 25(OH)D concentrations and prevent 25(OH)D insufficiency in order to extend the lifespan of KSD patients.
The use of liquid chromatography-tandem mass spectrometry in newborn screening for congenital adrenal hyperplasia: improvements and future perspectives
Authors: de Hora Mark , Heather Natasha , Webster Dianne , Albert Benjamin , Hofman Paul
Published: October 2023

Newborn screening for congenital adrenal hyperplasia using 17-hydroxyprogesterone by immunoassay remains controversial despite screening been available for almost 40 years. Screening is confounded by poor immunoassay specificity, fetal adrenal physiology, stress, and illness which can result in a large number of false positive screening tests. Screening programmes apply higher screening thresholds based on co-variates such as birthweight or gestational age but the false positive rate using immunoassay remains high. Mass spectrometry was first applied to newborn screening for congenital adrenal hyperplasia over 15 years ago. Elevated 17-hydroxprogesterone by immunoassay can be retested with a specific liquid chromatography tandem mass spectrometry assay that may include additional steroid markers. Laboratories register with quality assurance programme providers to ensure accurate steroid measurements. This has led to improvements in screening but there are additional costs and added laboratory workload. The search for novel steroid markers may inform further improvements to screening. Studies have shown that 11-oxygenated androgens are elevated in untreated patients and that the adrenal steroidogenesis backdoor pathway is more active in babies with congenital adrenal hyperplasia. There is continual interest in 21-deoxycortisol, a specific marker of 21-hydroxylase deficiency. The measurement of androgenic steroids and their precursors by liquid chromatography tandem mass spectrometry in bloodspots may inform improvements for screening, diagnosis, and treatment monitoring. In this review, we describe how liquid chromatography tandem mass spectrometry has improved newborn screening for congenital adrenal hyperplasia and explore how future developments may inform further improvements to screening and diagnosis.
The published trend of studies on COVID-19 and diabetes: bibliometric analysis
Authors: Li Yuanyuan , Peng Lei , Gu Wei
Published: October 2023

Background

Since the COVID-19 pandemic outbreak, diabetes mellitus (DM) has been at the core of the confirmed risk factors for fatal or critical care unit-treated COVID-19 and COVID-19 related complications. Although relevant studies on DM have developed rapidly during the COVID-19 pandemic. However, the aforementioned research results have not been systematically quantified by means of bibliometric analysis.

Purpose

The purpose of this study is to provide a comprehensive analysis of the current status and trends of publications related to DM research during the COVID19 epidemic.

Methods

A bibliometric analysis was performed using the Web of Science database. In this study, we used citespace, R software and R-Bibliometrix to analyze keywords, most-cited authors, most-cited countries, most-cited global documents, and co-occurrence and co-citation networks.

Results

A total of 1688 publications was included in this study. Investigators from the United States contributed the most publications. The United States, China and Europe have the most collaboration with the other countries/regions. A total of 3355 institutions made contributions to this study. Of the top 10 institutions with the most publications, N8 Research Partnership showed the most centrality. Among the top 10 journals, Diabetes Research and Clinical Practice published the most articles. Among authors included, Khunti Kamlesh is rated first with 27 papers and has the highest centrality. The most frequently co-cited article is entitled “Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study”. The most popular keywords included diabetes, mortality, diabetes, outcome, occurrences, risk, and type 1 diabetes.

Conclusion

This bibliometric study provides an overall picture of DM research and research trends during the COVID-19 pandemic and provides a basis for researchers to develop their next research strategies.
Design-based system performance assessment of a combined power and freshwater cogeneration system
Authors: Elfizon Elfizon , Nuñez Alvarez José Ricardo , Chammam Abdeljelil , Al-Kharsan Ibrahim H. , Jweeg Muhsin J. , Yánez-Moretta Patricio , Alayi Reza , Khan Imran , Byun Yung-Cheol , Madsen Dag Øivind
Published: October 2023

In this research, the design and use of combined systems for the simultaneous production of water, heat, and energy have been proposed, and, to fulfill the water, electricity, and heat demands of a hotel, modeling of the multi-effect evaporative desalination (MED) and combined heat and power (CHP) generation system was done. Then, the design of these two systems was administered in a combined way. This design was applied in order to evaluate the economy of the combined system compared to separate systems. The performed scenario was executed every 24 h during the two seasons of the year. The genetic algorithm was used to optimize this system, and it was considered the objective function to minimize the annual costs. The results showed that the nominal capacity of the gas turbine and backup boiler in the CHP + MED + thermal energy storage (TES) system was (14%) larger and (8.2%) smaller, respectively, compared to the CHP+ MED system. In addition, by using the energy storage tank in the combined CHP + MED system, 5.1% of the annual costs were reduced.
Can green investment improve China’s regional energy consumption structure? novel findings and implications from sustainable energy systems perspective
Authors: Liu Zhengyuan , Lam Johnny F. I. , Chen Hongxi , Lin Guochao , Chen Huangxin
Published: October 2023

Green investment can promote the low-carbon development of energy consumption structure in direct and indirect ways through financial support for new energy industry and pulling effect on environmental protection industry, which is of great significance to the sustainable development of economy and society. Through empirical analysis of the panel data of provinces and municipalities in China, this paper finds that the impact of green investment on the energy consumption structure is highly differentiated between regions: the development of green investment in the eastern region will inhibit the increase of the proportion of coal and other polluting energy sources in the energy consumption structure, which will help the energy consumption structure tend to develop in a decarbonized way; in the central region, the impact of green investment on the energy consumption structure is insignificant; and in the western region, green investment instead promotes the development of the energy consumption structure in a decarbonized way. In the western region, green investment instead promotes the proportion of coal and other polluting energy in the energy consumption structure. The main reason for this is that there are big differences in the level of economic development, characteristics of industrial structure, population size and technological level between the East, the Middle East and the West. It is an important measure to strengthen green investment and improve energy consumption structure to dynamically adjust green development goals, strengthen financial support for energy conservation and environmental protection industries, and narrow the regional development gap in all directions.