Beyond Vienna: MS/MS Option for the Neoma MC-ICP-MS.
Authors: Craig Grant , Roberts Jenny , Pfeifer Markus , Bouman Claudia , Lloyd Nicholas , Schwieters Johannes 
Published: March 2022

&lt;p&gt;The introduction and rapid adoption of triple quadrupole ICP-MS/MS in the last decade&lt;sup&gt;1&lt;/sup&gt; has seen the development of many exciting isotope ratio geoscience applications, including &lt;em&gt;in-situ&lt;/em&gt; Rb/Sr dating&lt;sup&gt;2&lt;/sup&gt;. By being able to restrict ions of specific mass-to-charge ratios (&lt;em&gt;m/z)&lt;/em&gt; only entering the collision/reaction cell, reactive gases such as O&lt;sub&gt;2&lt;/sub&gt;, NH&lt;sub&gt;3&lt;/sub&gt; and SF&lt;sub&gt;6&lt;/sub&gt; can be used to measure ions free of isobaric interferences. &amp;#160;However, many of the isotope ratio applications developed on triple quadrupole ICP-MS/MS would benefit from the excellent isotope ratio precision available from multicollector inductively coupled plasma mass spectrometry (MC-ICP-MS). In order to test the feasibility of MC-ICP-MS/MS, Thermo Fisher Scientific&amp;#8482; produced two prototype MC-ICP-MS/MS based on the Thermo Scientific&amp;#8482; Neptune Series&amp;#8482; MC-ICP-MS, named Proteus&lt;sup&gt;3&lt;/sup&gt; (in collaboration with the University of Bristol, UK) and Vienna&lt;sup&gt;4&lt;/sup&gt;. The Vienna MC-ICP-MS/MS improved on Proteus by introducing a novel pre-cell mass filter and hexapole collision/reaction cell, retaining the sensitivity and predictable mass bias of the Neptune Series MC-ICP-MS. For in-situ Rb/Sr dating both prototype systems reported better than fivefold improvements in precision over triple quadrupole ICP-MS/MS.&lt;/p&gt;&lt;p&gt;Since the development of the Vienna MC-ICP-MS/MS prototype, Thermo Fisher Scientific has introduced the Thermo Scientific Neoma&amp;#8482; MC-ICP-MS, blending cutting-edge and field proven technology from our Thermo Scientific&amp;#160;Ultra&amp;#8482;&amp;#160;high resolution IRMS and iCAP Qnova&amp;#8482; ICP-MS&lt;sup&gt;5&lt;/sup&gt;. Now with the MS/MS Option, the novel pre-cell mass filter and hexapole collision reaction cell design pioneered in Vienna has been bought to this most modern MC-ICP-MS platform. Any Neoma MC-ICP-MS can now be upgraded to full MS/MS capability, with the resulting MC-ICP-MS/MS having no compromises in sensitivity, accuracy or precision. With the ability to select a discrete range of masses to enter the collision/reaction cell, reactive gases such as O&lt;sub&gt;2&lt;/sub&gt;, SF&lt;sub&gt;6 &lt;/sub&gt;and NH&lt;sub&gt;3&lt;/sub&gt; can be used alongside H&lt;sub&gt;2&lt;/sub&gt; and He. Here we demonstrate how the Neoma MC-ICP-MS/MS can be used for a variety of applications, such as Ti, Fe, U and &lt;em&gt;in-situ&lt;/em&gt; Rb/Sr dating.&lt;/p&gt;&lt;p&gt;1.Tanimizu, M.; Sugiyama, N.; Ponzevera, E.; Bayon, G. Determination of Ultra-Low 236U/238U Isotope Ratios by Tandem Quadrupole ICP-MS/MS. &lt;em&gt;J. Anal. At. Spectrom.&lt;/em&gt; &lt;strong&gt;2013&lt;/strong&gt;, &lt;em&gt;28&lt;/em&gt;, 1372&amp;#8211;1376.&lt;/p&gt;&lt;p&gt;2. Zack, T.; Hogmalm, K. J. Laser Ablation Rb/Sr Dating by Online Chemical Separation of Rb and Sr in an Oxygen-Filled Reaction Cell. &lt;em&gt;Chem. Geol.&lt;/em&gt; &lt;strong&gt;2016&lt;/strong&gt;, &lt;em&gt;437&lt;/em&gt;, 120&amp;#8211;133.&lt;/p&gt;&lt;p&gt;3. Bevan, D.; Coath, C. D.; Lewis, J.; Schwieters, J.; Lloyd, N.; Craig, G.; Wehrs, H.; Elliott, T. In Situ Rb&amp;#8211;Sr Dating by Collision Cell, Multicollection Inductively-Coupled Plasma Mass-Spectrometry with Pre-Cell Mass-Filter, (CC-MC-ICPMS/MS). &lt;em&gt;J. Anal. At. Spectrom.&lt;/em&gt; &lt;strong&gt;2021&lt;/strong&gt;, &lt;em&gt;36&lt;/em&gt;, 917&amp;#8211;931.&lt;/p&gt;&lt;p&gt;4. Craig, G.; Wehrs, H.; Bevan, D. G.; Pfeifer, M.; Lewis, J.; Coath, C. D.; Elliott, T.; Huang, C.; Lloyd, N. S.; Schwieters, J. B. Project Vienna: A Novel Precell Mass Filter for Collision/Reaction Cell MC-ICPMS/MS. &lt;em&gt;Anal. Chem.&lt;/em&gt; &lt;strong&gt;2021&lt;/strong&gt;, &lt;em&gt;93&lt;/em&gt; (30), 10519&amp;#8211;10527.&lt;/p&gt;&lt;p&gt;5. Brochure: &lt;em&gt;Neoma Multicollector ICP-MS - Illuminating the edge of discovery&lt;/em&gt;&lt;span&gt; https://assets.thermofisher.com/TFS-Assets/CMD/brochures/br-30600-neoma-mc-icp-ms-br30600-en.pdf&lt;/span&gt;&lt;/p&gt;