bluuebunny/crossref_metadata_2025 huggingface dataset:
THAP9‐AS1 Promotes Tumorigenesis and Reduces ROS Generation through the JAK2/STAT3 Signaling Pathway by Increasing SOCS3 Promoter Methylation in Osteosarcoma
Authors: Yang Shuai , Wang Bing , Liu Chang , Wang Qizun , Wang Ronghuan , Su Weiliang , Zhu Youfu , Li Maohua , Guo Zhaoyang , Wu Xiaolin , Chen Feng
Published: October 2021

Increasing studies have demonstrated that dysfunction of long noncoding RNAs (lncRNAs) plays critical roles in the development of human cancers. THAP9‐AS1 has been reported to be dysregulated and associated with tumor progression in some cancers. However, the function and mechanism of THAP9‐AS1 in osteosarcoma (OS) remain unclear. In the present study, we found that the expression of THAP9‐AS1 was significantly upregulated in OS tissues and associated with the advanced stage of tumors and poor prognosis of patients. Blast comparison results showed that the SOCS3 promoter region and THAP9‐AS1 had base complementary pairing binding sites. The interactions between THAP9‐AS1, DNA methyltransferases (DNMTs), and SOCS3 were assessed by RIP and ChIP assays. The results of methylation‐specific PCR (MSP) and bisulfite sequencing PCR (BSP) validated that THAP9‐AS1 enhanced the methylation level of the SOCS3 promoter. The mRNA levels of SOCS3 in OS cells could be reversed by the demethylation agent 5‐aza‐2 ′‐deoxycytidine. The mRNA expression of SOCS3 was downregulated in OS tissues and negatively correlated with THAP9‐AS1 expression in tumors. Moreover, the western blot and immunofluorescence (IF) assay data showed that THAP9‐AS1 activated the JAK2/STAT3 signaling pathway by upregulating p‐JAK2 and p‐STAT3 and the nuclear translocation of p‐STAT3. Functionally, ectopic expression of THAP9‐AS1 promoted cell proliferation, migration, and invasion and inhibited apoptosis, and this phenomenon could be reversed by SOCS3. Introduction of the JAK/STAT inhibitor AG490 partially abolished the stimulative effect of THAP9‐AS1 on cellular processes. In addition, THAP9‐AS1 decreased oxidative stress by reducing reactive oxygen species (ROS) and enhancing the mitochondrial membrane potential of OS cells via the SOCS3/JAK2/STAT3 pathway. Stable overexpression of THAP9‐AS1 contributed to tumor growth and metastasis in vivo. In total, our findings suggested that upregulation of THAP9‐AS1 might recruit DNMTs to epigenetically inhibit SOCS3, thereby activating the JAK2/STAT3 signaling pathway and oncogenesis of OS. These results provide novel insights for the understanding of OS progression.
Activation of FGD5-AS1 Promotes Progression of Cervical Cancer through Regulating BST2 to Inhibit Macrophage M1 Polarization
Authors: Liu Guokun , Du Xuan , Xiao Li , Zeng Qing , Liu QianLing
Published: October 2021

Accumulating evidence has elucidated the biological function of lncRNAs in various tumors. FGD5 antisense RNA 1 (FGD5-AS1) is identified as a significant tumor regulator in malignancies. Up to now, the detailed function of FGD5-AS1 in cervical cancer and its underlying molecular mechanisms remain uninvestigated. Bone marrow stromal cell antigen 2 (BST2) can play critical roles in immune response, and the roles of BST2 in cervical cancer was explored currently. The level of FGD5-AS1 and BST2 was detected by qRT-PCR in cervical cancer cells. FGD5-AS1 and BST2 expression was significantly upregulated in cervical cancer cells. Then, the decrease of FGD5-AS1 greatly repressed cervical cancer cell growth in vitro. In addition, FGD5-AS1 silencing repressed BST2 expression and suppressed M2 macrophage polarization. Mechanistically, we confirmed that FGD5-AS1 sponged miR-129-5p to reduce its inhibition on BST2. Furthermore, lack of BST2 depressed cervical cancer cell growth, while inducing apoptosis. Loss of BST2 induced M1 macrophage polarization while blocking M2 macrophage polarization. For another, we demonstrated that FGD5-AS1-triggered M2 macrophage polarization was remarkably reversed by miR-129-5p via suppressing BST2. In conclusion, FGD5-AS1 induced M2 macrophage polarization via sponging miR-129-5p and modulating BST2, thus contributing to cervical cancer development. Our findings revealed FGD5-AS1/miR-129-5p/BST2 as a new potential target for cervical cancer.
A FJSSP Method Based on Dynamic Multi-Objective Squirrel Search Algorithm
Authors: Wang Yanjiao , Han Jieru
Published: October 2021

This paper comprehensively analyzes the characteristics of flexible job shop scheduling problem (FJSSP), takes the dynamic factors in the actual scheduling process such as the arrival and departure of jobs, the breakdown and recovery of machines into account at the same time, and establishes a new dynamic multi-objective mathematical model. Take the Squirrel Search Algorithm (SSA) as the core evolution strategy, and combine the multi-objective framework and the dynamic processing technology to solve the established mathematical model. Experimental results show that the mathematical model proposed in this paper can solve the flexible job shop scheduling problem effectively. Compared with other mathematical models, the mathematical model established in this paper can keep better balance between the efficiency and stability.
Analysis of Shared Genetic Regulatory Networks for Alzheimer’s Disease and Epilepsy
Authors: Wang Xiao-Dan , Liu Shuai , Lu Hui , Guan Yalin , Wu Hao , Ji Yong
Published: October 2021

Alzheimer’s disease (AD) and epilepsy are neurological disorders that affect a large cohort of people worldwide. Although both of the two diseases could be influenced by genetic factors, the shared genetic mechanism underlying the pathogenesis of them is still unclear. In this study, we aimed to identify the shared genetic networks and corresponding hub genes for AD and epilepsy. Firstly, the gene coexpression modules (GCMs) were constructed by weighted gene coexpression network analysis (WGCNA), and 16 GCMs were identified. Through further integration of GCMs, genome‐wide association studies (GWASs), and expression quantitative trait loci (eQTLs), 4 shared GCMs of AD and epilepsy were identified. Functional enrichment analysis was performed to analyze the shared biological processes of these GCMs and explore the functional overlaps between these two diseases. The results showed that the genes in shared GCMs were significantly enriched in nervous system‐related pathways, such as Alzheimer’s disease and neuroactive ligand‐receptor interaction pathways. Furthermore, the hub genes of AD‐ and epilepsy‐associated GCMs were captured by weighted key driver analysis (wKDA), including TRPC1, C2ORF40, NR3C1, KIAA0368, MMT00043109, STEAP1, MSX1, KL, and CLIC6. The shared GCMs and hub genes might provide novel therapeutic targets for AD and epilepsy.
A Case of Nasopharyngeal Mycobacteriosis with Bony Erosion of the External Skull Base
Authors: Matsuo Kohei , Tanaka Satoshi , Sakata Masayuki , Takeda Hiroki , Nagata Akihiro , Mori Masashi , Ito Rie , Yamamoto Yoshifumi , Ueno Kiyonobu , Uno Atsuhiko
Published: October 2021

Primary nasopharyngeal mycobacteriosis is a rare disease. We present a case in which skull base bone erosion appeared and was alleviated during the course of the treatment. Bone complications occur in osteoarticular mycobacteriosis, but their occurrence in primary nasopharyngeal mycobacteriosis has not been reported. A 77-year-old immunocompromised Asian woman presented with a right occipitotemporal headache. An ulcerative mass covered with a thick yellowish discharge was found in the roof and posterior walls of the right nasopharynx. Because histopathological examination indicated the presence of mycobacterial infection, we began using antituberculosis medication for the treatment because of the possibility of primary nasopharyngeal tuberculosis. However, this was followed by glossopharyngeal and vagus nerve paralysis. Computed tomography (CT) showed a diffuse enhancing mucosal irregularity in the nasopharynx with bony erosion of the external skull base. Deep tissue biopsy was repeated to differentiate it from malignant lesions, and drainage of pus from the right nasopharynx was confirmed. Subsequently, the headache, neurological findings, and the yellowish discharge disappeared, and the bony erosion of the external skull base was alleviated. Surgical intervention should also be considered for drug-resistant mycobacteriosis. We concluded that mycobacteriosis should also be considered apart from carcinoma even if CT shows a diffuse enhancing mucosal irregularity with bone destruction in the nasopharynx.
Research Progress of Crop Disease Image Recognition Based on Wireless Network Communication and Deep Learning
Authors: Yu Yuanhui
Published: October 2021

The traditional digital image processing technology has its limitations. It requires manual design features, which consumes manpower and material resources, and identifies crops with a single type, and the results are bad. Therefore, to find an efficient and fast real‐time disease image recognition method is very meaningful. Deep learning is a machine learning algorithm that can automatically learn representative features to achieve better results in areas of image recognition. Therefore, the purpose of this paper is to use deep learning methods to identify crop pests and diseases and to find efficient and fast real‐time image recognition methods of disease. Deep learning is a newly developed discipline in recent years. Its purpose is to study how to actively obtain a variety of feature representation methods from data samples and rely on data‐driven methods, a series of nonlinear transformations are applied to finally collect the original data from specific to abstract, from general to specified semantics, and from low‐level to high‐level characteristic forms. This paper analyzes the classical and the latest neural network structure based on the theory of deep learning. For the problem that the network based on natural image classification is not suitable for crop pest and disease identification tasks, this paper has improved the network structure that can take care of both recognition speed and recognition accuracy. We discussed the influence of the crop pest and disease feature extraction layer on recognition performance. Finally, we used the inner layer as the main structure to be the pest and disease feature extraction layer by comparing the advantages and disadvantages of the inner and global average pooling layers. We analyze various loss functions such as Softmax Loss, Center Loss, and Angular Softmax Loss for pest identification. In view of the shortcomings of difficulty in loss function training, convergence, and operation, making the distance between pests and diseases smaller and the distance between classes more greater improved the loss function and introduced techniques such as feature normalization and weight normalization. The experimental results show that the method can effectively enhance the characteristic expression ability of pests and diseases and thus improve the recognition rate of pests and diseases. Moreover, the method makes the pest identification network training simpler and can improve the pest and disease recognition rate better.
Intervention Effect of Rapid Rehabilitation Nursing Combined with Continuous Nursing after Discharge on Patients with Cerebral Infarction in Recovery Period and the Changes in Motor Function, Mental State, and Quality of Life
Authors: Xie Rongxiang , Chen Yi , Chen Kailang , Chen Zan
Published: October 2021

Objective. To explore the effect of rapid rehabilitation nursing combined with continuous nursing after discharge on patients with cerebral infarction (CI) in recovery period and its influence on motor function, mental state, and quality of life. Methods. From January 2018 to December 2020, 136 patients with CI in recovery period were selected and randomly divided into control group (n = 68) and observation group (n = 68). The control group was given routine nursing, and the observation group was given rapid rehabilitation nursing combined with continuous nursing after discharge. The general clinical data of the two groups were recorded, and the nursing efficiency, modified Barthel index scale (MBI), stroke patients motor assessment scale (MAS), self-rating anxiety and depression scale (SAS and SDS), and quality of life assessment scale (QLI) were compared between the two groups. Results. The nursing effective rate of the observation group (94.12%, 64/68) was higher than that of the control group (82.35%, 56/68) (

P
<
0.05

). The MBI score, MAS score, and QLI score in the observation group were higher than those in the control group, while the SAS and SDS scores in the observation group were lower than those in the control group (

P
<
0.05

). Conclusion. Rapid rehabilitation nursing combined with continuous nursing after discharge can promote the rapid recovery of patients with CI in recovery period, which can improve the patient’s motor function, reduce unhealthy psychology, and improve the quality of life.
Mineral Composition, Phenolic Content, and In Vitro Antidiabetic and Antioxidant Properties of Aqueous and Organic Extracts of Haloxylon scoparium Aerial Parts
Authors: Lachkar Nacima , Lamchouri Fatima , Bouabid Khadija , Boulfia Mohamed , Senhaji Souad , Stitou Mourad , Toufik Hamid
Published: October 2021

Haloxylon scoparium is a plant widely used in traditional medicine for the treatment of diabetes. Hence, this study focuses on the mineralogical and chemical composition and evaluation of the antidiabetic and antioxidant activities of the aerial part of this species. The mineralogical analysis was done by inductively coupled plasma atomic emission spectrometry (ICP-AES). The phytochemical study consisted in the preparation of different extracts from the aerial part by aqueous and organic extraction using Soxhlet and cold maceration. Then, phytochemical screening was performed on the plant powder and on the extracts, which is completed by spectrophotometric quantification of total polyphenols, flavonoids, and catechic tannins. The evaluation of antidiabetic activity was done by three enzymes: a-amylase, a-glucosidase, and ß-galactosidase, and that of antioxidant activity was done by five methods: H2O2, DPPH, ABTS, FRAP, and reducing power (RP). Mineralogical analysis revealed the presence of iron, potassium, magnesium, phosphorus, sodium, copper, calcium, strontium, selenium, and zinc. The studied part is rich in alkaloids, flavonoids, catechic tannins, and saponins. The methanolic extract is rich in total polyphenols (161.65 ± 1.52 Ug EAG/mg E), and the ethyl acetate extract has high levels of catechic tannins (23.69 ± 0.6 Ug EC/mg E). In addition, the decoctate expresses a high flavonoid content of 306.59 ± 4.35 Ug EQ/mg E. The in vitro evaluation of the antidiabetic activity showed that the decoctate has a higher inhibitory capacity on a-glucosidase (IC50 = 181.7 ± 21.15 ug/mL) than acarbose (IC50 = 195 ± 6.12 ug/mL). The results of the antioxidant activity showed that the methanolic extract and the decoctate present a percentage of hydrogen peroxide (H2O2) scavenging (20.91 ± 0.27 and 16.21 ± 0.39%) higher than that of ascorbic acid (14.35 ± 0.002%). Positive correlations obtained between the total polyphenol content and the antioxidant activity of the extracts were studied. A positive correlation of a-amylase inhibitory activity was also recorded with the antioxidant activity tests.
Immunosuppressant Management in Renal Transplant Patients with COVID‐19
Authors: Ahmadian Elham , Zununi Vahed Sepideh , Mammadova Shakar , Abediazar Sima
Published: October 2021

The coronavirus disease 2019 (COVID‐19) pandemic poses a special risk for both immunosuppressed patients, especially transplant recipients. Although the knowledge about this infection is growing, many uncertainties remain, particularly regarding the kidney. Kidney transplant recipients (KDRs) should be considered immunocompromised hosts since a potential risk for infection, comorbidity, and immunosuppression exposure exists. Additionally, the management of immunosuppressive agents in KDRs remains challenging. Potential drug interactions with immunosuppressive treatment escalated the risk of unwanted side effects. In this review, we aimed to attain an augmented awareness and improved management immunosuppressant for COVID‐19 KDRs.
The Mechanism Causing an Increase in Farmland Transfer Rent and the Restraining Effect of High Rent on Grain Production
Authors: Li Hong , Zhang Xian
Published: October 2021

The rent of farmland transfer represents the economic realization of farmland contracts and management rights of agricultural households. A three-stage dynamic game model with three players is constructed in this paper to study the mechanism causing an increase in farmland transfer rent. Based on the theory of producer equilibrium and production possibility boundaries, this paper studies the restraining effect of high rent on grain production and analyzes the factors that prevent the decline in grain production at present. Combined with the process of farmland transfer in a village, both the mechanism causing an increase in farmland transfer rent and the restraining effect of high rent on grain production are empirically analyzed. The conclusion is as follows: the basic direction of farmland transfer is from farmers with a low production capacity to farmers with a high production capacity, and the rent level is determined by the transferors with high production capacity; about half of the economies of scale profits and two-thirds of transferees’ subsidies are converted into farmland transfer rents. High farmland transfer rent reinforces “nongrain” and “nonagricultural” behaviors. Finally, it is suggested that farmers should be given vocational training in agricultural production, “farmland transfer tax” should be levied on excessive farmland transfer rent, and transferees should be subsidized for grain production.
Experimental Study on the Dynamic Modulus and Damping Ratio of Compacted Loess under Circular Dynamic Stress Paths
Authors: Yang Liguo , Shao Shengjun , Wang Zhi
Published: October 2021

Dynamic loads such as earthquakes and traffic will simultaneously generate vertical dynamic stress and horizontal shear stress in the foundation soil. When the vertical dynamic stress amplitude is twice the horizontal shear dynamic stress amplitude, and the phase difference between them is 90°, a circular dynamic stress path is formed in the τzθd ~ (σzd − σθd)/2 stress coordinate system. To simulate the stress state of soil in the area of the circular dynamic stress path caused by bidirectional dynamic stress coupling, a series of tests of compacted loess under the action of a circular dynamic stress path were carried out using a hollow cylindrical torsion shear apparatus. The effects of the mean principal stress, dry density, and deviatoric stress ratio (the ratio of deviator stress to average principal stress) on the dynamic modulus and damping ratio of compacted loess were mainly studied. The test results show that, under the action of the circular dynamic stress path, the larger the mean principal stress is, the larger the dynamic compression modulus and dynamic shear modulus are. The dynamic compression modulus increases obviously with increasing dry density, but the dynamic shear modulus increases only slightly. When the deviator stress ratio increases from 0 to 0.4, the dynamic compression modulus and dynamic shear modulus increase to a certain extent. In addition, the greater the dry density and deviatoric stress ratio are, the greater the initial dynamic compression modulus and initial dynamic shear modulus of the compacted loess. The dynamic compression damping ratio of compacted loess increases with increasing mean principal stress, but the dynamic shear damping ratio decreases with increasing mean principal stress. Dry density basically has no effect on the dynamic compression damping ratio and dynamic shear damping ratio of compacted loess. When the dynamic strain exceeds 1%, the greater the deviatoric stress ratio is, the smaller the dynamic compression damping ratio and the dynamic shear damping ratio are. The research results can provide reference for the study of dynamic modulus and damping ratio of loess under special stress paths.
Association between Congenital Cytomegalovirus Infection and Brain Injury in Neonates: A Meta-analysis of Cohort Studies
Authors: Zhang Li , Li Zhankui , Han Xiang , Du Hongyan , Cao Yingli , Liu Yingmei , Wang Wenfeng
Published: October 2021

Objective. To assess association between congenital cytomegalovirus (CMV) infection and brain injury in neonates. Methods. The literatures from inception to November 4, 2020, were searched through PubMed, Embase, Cochrane Library, and Web of Science. Heterogeneity test was conducted for each indicator and measured byI2statistics. IfI2≥50%, the random effects model was applied; otherwise, the fixed effects model was used. Sensitivity analysis was performed for all models. Weighed mean difference (WMD) was used as the effect size for measurement data, and risk ratio (RR) was as the effect indicator. Results. A total of 13 studies, including 4,262 congenital CMV infection neonates, were enrolled in this study. Our results showed that the rate of hearing impairment (RR: 2.105, 95% CI: (1.115, 3.971),P=0.002), sensorineural hearing loss (SNHL) (RR: 17.051, 95% CI: (6.201, 46.886),P<0.001), and microcephaly (RR: 2.283, 95% CI: (1.325, 3.935), P =0.003) in neonates infected congenital CMV was higher than that in control group. Conclusion. The risks of hearing impairment, SNHL, and microcephaly in neonates during childhood may be associated with congenital CMV infection. It is necessary to establish neonatal screening programs and comprehensive diagnostic tests for patients to reduce the risk of adverse brain damage to the congenital CMV infection as early as possible and to improve the prognosis of the newborn.
CAx Integration and Its Design Application Based on Feature Extension of Sensor Components
Authors: Tang Yaohong , Song Mengmeng , Xiao Shungen , Liu Xiangui , Liang Guoxiang
Published: October 2021

In order to improve the information and product originality level of intelligent manufacturing industry based on sensor technology, this paper summarizes the current situation of CAx integration based on sensor technology and its design application and analyzes the shortcomings of existing CAx integration, aiming at accurate, complete, timely, and barrier‐free transfer of sensor product data and information between CAx system and MRPII/ERP management information system. The concept and information model of feature extension of sensor components oriented to the whole process of sensor intelligent manufacturing is presented. Taking feature extension of sensor components as the integration link, CAx integration framework structure and its design application mode based on feature extension are established, while key technologies and implementation ideas to realize the integration and the design application are put forward, which provides an effective path to realize the sensor integration of CAx and management information systems such as MRPII/ERP.
[Retracted] Human Motion Representation and Motion Pattern Recognition Based on Complex Fuzzy Theory
Authors: Li Xiangkun , Sun Guoqing , Li Yifei
Published: October 2021

With the development of science and technology, the introduction of virtual reality technology has pushed the development of human‐computer interaction technology to a new height. The combination of virtual reality and human‐computer interaction technology has been applied more and more in military simulation, medical rehabilitation, game creation, and other fields. Action is the basis of human behavior. Among them, human behavior and action analysis is an important research direction. In human behavior and action, recognition research based on behavior and action has the characteristics of convenience, intuition, strong interaction, rich expression information, and so on. It has become the first choice of many researchers for human behavior analysis. However, human motion and motion pictures are complex objects with many ambiguous factors, which are difficult to express and process. Traditional motion recognition is usually based on two‐dimensional color images, while two‐dimensional RGB images are vulnerable to background disturbance, light, environment, and other factors that interfere with human target detection. In recent years, more and more researchers have begun to use fuzzy mathematics theory to identify human behaviors. The plantar pressure data under different motion modes were collected through experiments, and the current gait information was analyzed. The key gait events including toe‐off and heel touch were identified by dynamic baseline monitoring. For the error monitoring of key gait events, the screen window is used to filter the repeated recognition events in a certain period of time, which greatly improves the recognition accuracy and provides important gait information for motion pattern recognition. The similarity matching is performed on each template, the correct rate of motion feature extraction is 90.2%, and the correct rate of motion pattern recognition is 96.3%, which verifies the feasibility and effectiveness of human motion recognition based on fuzzy theory. It is hoped to provide processing techniques and application examples for artificial intelligence recognition applications.
Phase Behavior Analysis of CO2 and Formation Oil System
Authors: Tang Lei , Zhang Tongyao , Li Baogang , Zhang Lu , Han Dong
Published: October 2021

In this paper, there are nine oil samples to explore the characteristics of formation oil at different CO2 injection rate, and the characteristics include bubble point pressure, volume expansion coefficient, viscosity, density, and average molecular weight, composition of gas and liquid phase, and asphalt sediment. According to the experimental results of early nine oil samples of swelling tests, in high temperature and high pressure conditions, characteristics and changing rules of properties of formation oil, including bubble point pressure, volume expansion coefficient, viscosity, density, and average molecular weight, composition of gas and liquid phase, and asphalt sediment, were evaluated and analyzed at different CO2 injection rate systematically. The research not only can provide guides for petroleum engineers when they need to adjust the injection and production programs, but also can provide comparatively comprehensive experimental rules for researches on enhanced oil recovery (EOR) mechanisms of gas miscible and nonmiscible flooding. Moreover, phase parameters of different formation oil system can be extracted for reservoir numerical simulation.
Epstein-Barr Virus Induces Lymphangiogenesis and Lympth Node Metastasis via Upregulation of VEGF-C in Nasopharyngeal Carcinoma
Authors: Li Deng-Ke , Chen Xing-Rui , Wang Li-Na , Wang Jia-Hong , Wen Yue-Ting , Zhou Zi-Ying , Li Ji-Ke , Liu Jing-Xian , Cai Lin-Bo , Zhong Shui-Sheng , Lyu Xiao-Ming , Damola Faleti Oluwasijibomi , Li Min-Ying , Zhang Jing-Jing , Zeng Yu-Mei , Wang Qian-Li , Zhang Qian-Bing , Lyu Hao , Fu Xiao-Yan , Wang Wei , Li Xin , Huang Zhong-Xi , Yao Kai-Tai
Published: October 2021

Lymphatic metastasis is a common clinical symptom in nasopharyngeal carcinoma (NPC), the most common Epstein-Barr virus (EBV)-associated head and neck malignancy. However, the effect of EBV on NPC lymph node (LN) metastasis is still unclear. In this study, we demonstrated that EBV infection is strongly associated with advanced clinical N stage and lymphangiogenesis of NPC. We found that NPC cells infected with EBV promote LN metastasis by inducing cancer-associated lymphangiogenesis, whereas these changes were abolished upon clearance of EBV genomes. Mechanistically, EBV-induced VEGF-C contributed to lymphangiogenesis and LN metastasis, and PHLPP1, a target of miR-BART15, partially contributed to AKT/HIF1a hyperactivity and subsequent VEGF-C transcriptional activation. In addition, administration of anti-VEGF-C antibody or HIF1α inhibitors attenuated the lymphangiogenesis and LN metastasis induced by EBV. Finally, we verified the clinical significance of this prometastatic EBV/VEGF-C axis by determining the expression of PHLPP1, AKT, HIF1a, and VEGF-C in NPC specimens with and without EBV. These results uncover a reasonable mechanism for the EBV-modulated LN metastasis microenvironment in NPC, indicating that EBV is a potential therapeutic target for NPC with lymphatic metastasis.

Implications:

This research demonstrates that EBV induces lymphangiogenesis in NPC by regulating PHLPP1/p-AKT/HIF1a/VEGF-C, providing a new therapeutic target for NPC with lymphatic metastasis.
Evolving Views on the Pallium
Authors: Medina Loreta , Abellán Antonio , Desfilis Ester
Published: October 2021

The pallium is the largest part of the telencephalon in amniotes, and comparison of its subdivisions across species has been extremely difficult and controversial due to its high divergence. Comparative embryonic genoarchitecture studies have greatly contributed to propose models of pallial fundamental divisions, which can be compared across species and be used to extract general organizing principles as well as to ask more focused and insightful research questions. The use of these models is crucial to discern between conservation, convergence or divergence in the neural populations and networks found in the pallium. Here we provide a critical review of the models proposed using this approach, including tetrapartite, hexapartite and double-ring models, and compare them to other models. While recognizing the power of these models for understanding brain architecture, development and evolution, we also highlight limitations and comment on aspects that require attention for improvement. We also discuss on the use of transcriptomic data for understanding pallial evolution and advise for better contextualization of these data by discerning between gene regulatory networks involved in the generation of specific units and cell populations versus genes expressed later, many of which are activity dependent and their expression is more likely subjected to convergent evolution.
The Feasibility of Mechanical Thrombectomy on Single-Plane Angiosuite: An In-Depth Analysis of Procedure Time
Authors: Inoue Hiroyasu , Oomura Masahiro , Nishikawa Yusuke , Mase Mitsuhito , Matsukawa Noriyuki
Published: October 2021

Introduction: Mechanical thrombectomy (MT) is usually performed on biplane (BP) angiosuites. When the BP angiosuite is not available, the single-plane (SP) angiosuite may be a substitute. However, the feasibility of MT performed on the SP angiosuite is yet to be elucidated. Therefore, we investigated the alternative effect of the SP angiosuite on the detailed division of procedure time, recanalization rate, and outcome in patients with anterior circulation infarction. Methods: The subjects included 80 consecutive patients with anterior circulation infarction who underwent MT at our hospital between May 2015 and December 2020. Demographics and characteristics of the BP and SP groups were assessed and compared. The time from puncture to guiding catheter placement (P-G), time from guiding catheter placement to recanalization (G-R), and time from puncture to recanalization (P-R) were also extracted. A good outcome was defined as a modified Rankin scale score ≤2 at 3 months. Results: Of the 80 patients, 67 and 13 were treated with BP and SP angiosuites, respectively. There were no differences in age, sex, complications, Alberta Stroke Program Early CT Score, National Institutes of Health Stroke Scale score at onset, occlusion site, rate of recombinant tissue-type plasminogen activator administration, stroke subtype, recanalization rate, and complications between the 2 groups. The rate of a good outcome was not different between the 2 groups. P-G was significantly longer in the SP group than in the BP group, whereas there was no significant difference in G-R and P-R between the 2 groups (P-G: BP 29.9 ± 21.8 vs. SP 48.5 ± 43.6 min, p = 0.04). Conclusion: MT performed on the SP angiosuite tended to prolong the time for guiding catheter placement. However, there was no difference in the overall procedure time, recanalization rate, or outcome between BP and SP angiosuites. Therefore, if the BP angiosuite is not available, the use of the SP angiosuite should be encouraged.
Corpora, translation, terminology… and beyond: objectives and perspectives
Authors: Maia Belinda
Published: October 2021

This paper will not describe any specific research in corpus linguistics. Instead, it will first reflect on the way many of us teaching languages and translation in university departments develop and use corpora in our research and teaching methodology. One of the objectives is to highlight the work by Professor Stella Tagnin and those of us with whom she has worked over twenty years, even if it does not bring anything new to the immediate area. It will go on to analyze how, apart from the didactic uses of these resources, and related research, their potential for Natural Language Processing (NLP) became increasingly important, and demonstrate how the methodology of corpus linguistics is now used in various disciplines, especially in interdisciplinary research. This analysis was prompted by involvement in a project to advise universities in two Central Asian countries on the creation of a masters’ degree in computational linguistics. The languages of these countries are very different from Western European languages, which obliged a re-assessment of my experience in linguistics and NLP in the context of English and Portuguese, when considering how the world’s less-resourced languages could join the mainstream of computational linguistics.
Tradução intralinguística, estratégias de equivalência e acessibilidade textual e terminológica
Authors: Finatto Maria José Bocorny , Tcacenco Lucas Meireles
Published: October 2021

O artigo situa a simplificação de textos especializados como tradução intralinguística. À luz de estratégias de equivalência descritas por Baker ([1992] 2018), contrastam-se textos originais e simplificados de um corpus composto por textos que acompanham experimentos em um museu de ciências e tecnologia do Brasil. Do pareamento entre textos-fonte considerados complexos, escritos para público leigo em geral, e suas versões lexical e sintaticamente adaptadas para público infanto-juvenil, verificam-se estratégias de equivalência nas simplificações. Por fim, apresentam-se ponderações teóricas e metodológicas para a simplificação de textos de temática científica em meio aos estudos de Tradução, Terminologia e Linguística de Corpus.
A complexidade de enunciados de tarefas de produção escrita no Celpe-Bras e no Enem
Authors: Nagasawa Ellen Yurika , Schlatter Margarete
Published: October 2021

Inferências feitas a partir de avaliações padronizadas têm grande impacto na vida de examinandos. Partindo dessa preocupação social e ética, este artigo analisa características dos enunciados das tarefas de produção escrita do Celpe-Bras e do Enem (corpus de referência), para descrever sua complexidade, assumindo-a como um dos fatores preditivos do sucesso em responder a tarefa. Utilizando métodos da Linguística de Corpus, os corpora foram analisados para identificação de complexidade textual e padrões lexicais e sintáticos. A análise mostra enunciados com construções específicas para cada exame e diferenças quanto a seus níveis de complexidade e ao grau de explicitação de orientações para a escrita. Os resultados podem contribuir para o debate acerca da validade de exames de alto impacto e de seus usos sociais.
Learning from others' experience: A taste of parallel corpus analysis for translation students and budding corpus researchers
Authors: Bernardini Silvia
Published: October 2021

This contribution describes the potential of parallel corpus analysis for the development of research skills in the translation classroom. Using culinary texts as a case in point, and more specifically a culturally salient Italian text from the turn of the 19th century (Pellegrino Artusi's La scienza in cucina e l'arte del mangiar bene/Science in the kitchen and the art of eating well, in its original Italian and translated English version), a detailed analysis is offered of the Italian equivalents of the verb lemma COOK and of the English equivalents of the Italian verb lemma CUOCERE, showing how the paradigmatic and syntagmatic insights thus obtained could be used to construct bilingual lexical/terminological profiles of units of meaning, and/or to shed light on translation strategies and norms, depending on one's research hypotheses and variables. Two more unorthodox uses of parallel corpora to tap into translators' domain-specific knowledge, and as aids in the interpretation of culturally salient historical and literary texts, are also discussed.
Sobre a busca por equivalentes funcionais em um corpus comparável português-inglês de críticas gastronômicas
Authors: Rebechi Rozane Rodrigues , Schabbach Giulia Rotava , Freitag Patrícia Helena
Published: October 2021

O objetivo deste artigo é apresentar a metodologia adotada na busca por equivalentes para os termos e fraseologias que compõem um glossário bilíngue português-inglês de críticas gastronômicas. As traduções de textos culinários muitas vezes revelam apagamento de elementos culturais e perda de convencionalidade, possivelmente devido à escassez de obras de referência na área. Para auxiliar tradutores e redatores a produzirem textos que levem em conta a naturalidade e as diferenças entre línguas e culturas, compilamos um corpus comparável português brasileiro-inglês estadunidense de críticas gastronômicas e fizemos um levantamento de termos funcionalmente equivalentes. Apoiamo‑nos nos pressupostos da Linguística de Corpus e da Teoria Funcionalista da Tradução. As análises quantitativa e qualitativa mostraram que, em diferentes graus nos dois idiomas, esse gênero textual faz uso expressivo de linguagem metafórica e idiomática na descrição de serviços, ambientes e pratos.
Trio elétrico ou bandwagon? Um estudo das estratégias de tradução de referentes culturais em textos turísticos
Authors: Marqueze Giovana Martins de Castro
Published: October 2021

Para que o fluxo de turistas estrangeiros que chegam ao Brasil tenha acesso a informações sobre os serviços oferecidos pelo setor turístico, textos turísticos são produzidos em larga escala e em diversos idiomas. Como é de se esperar, referentes culturais abundam nesses textos, sendo um desafio constante com o qual os tradutores devem lidar. Dessa forma, à luz da teoria funcionalista da tradução de Nord (1991, 1997) e de Reiss e Vermeer (1984) e com a Linguística de Corpus como metodologia, analisamos as traduções do português para o inglês de textos turísticos sobre o Brasil publicados pela EMBRATUR a fim de descobrir quais estratégias são empregadas na tradução de referentes culturais e se elas colaboram para o cumprimento do propósito desses textos na cultura-meta. As estratégias são descritas com base na lista de estratégias para tradução de referentes culturais proposta por Marco (2002).
The Impact of Corequisite Math on Community College Student Outcomes:
Evidence from Texas
Authors: Meiselman Akiva Yonah , Schudde Lauren
Published: October 2021

Developmental education (dev-ed) aims to help students acquire knowledge and skills necessary to succeed in college-level coursework. The traditional prerequisite approach to postsecondary dev-ed—where students take remedial courses that do not count toward a credential—appears to stymie progress toward a degree. At community colleges across the country, most students require remediation in math, creating a barrier to college-level credits under the traditional approach. Corequisite coursework is a structural reform that places students directly into a college-level course in the same term they receive dev-ed support. Using administrative data from Texas community colleges and a regression discontinuity design, we examine whether corequisite math improves student success compared with traditional prerequisite dev-ed. We find that corequisite math quickly improves student completion of math requirements without any obvious drawbacks, but students in corequisite math were not substantially closer to degree completion than their peers in traditional dev-ed after three years.
Planning disorders in patients with schizophrenia: potential role of short-term memory and attention
Authors: Alekseev Andrey A. , Rupchev George E. , Tkhostov Alexander Sh.
Published: October 2021

Background. Although planning disorders in schizophrenia are a fairly reliably established fact, the mechanisms of these disorders remain not fully clarified. Given the complex nature of planning, the presence of its disturbances can be influenced by disturbances of other mental processes. Objective. Comparison of the links between planning, short-term memory, attention and abstract thinking in patients with schizophrenia and in normal. Design. 50 patients with schizophrenia (14 females, age 34.92±8.54; illness duration 8.34±5.87) and 50 healthy volunteers (14 females, age 32.42±7.26) were examined. Assessment included: Tower of London-Test (TOL-DX) for planning assessment; Benton’s test (BVTR) for short-term memory assessment; sub-test Similarity (from WAIS) for abstract thinking assessment; Schulte Tables for assessment of attention; Wisconsin Card Sorting Test to assess cognitive flexibility. Results. Patients showed significantly worse results in all parameters, which indicates that patients have impairments in all assessed cognitive functions. The revealed relationships between planning and other cognitive processes in schizophrenic patients and healthy subjects were significantly different. In healthy subjects, the effectiveness of planning was found to be associated only with abstract thinking. At the same time, in patients with schizophrenia, associations were found between the effectiveness of planning and all the other cognitive processes (short-term memory, attention, set-shifting). Conclusion. The preservation of planning in schizophrenia is associated with the preservation of other mental processes. Short-term memory and attention are necessary, but not sufficient conditions for the realization of the planning process.
Psychological predictors of apathy in the middle and late adulthood
Authors: Zolotareva Alena A. , Averina Polina A. , Timoshina Anastasiia L.
Published: October 2021

Background. Apathy is one of the most common symptoms in the adulthood, however, its psychological predictors are still poorly understood. Objective. This study was aimed to examine the psychological predictors of apathy in the middle and late adulthood. Design. The sample consisted of 188 participants aged 50 to 83 years. This study is cross-sectional. Potential predictors of apathy (i.e., depression, subjective vitality, subjective happiness and satisfaction with life) were evaluated using multiple regression analysis. The diagnostic battery included the Zolotareva’s Apathy Scale and Russian-language versions of the Geriatric Depression Scale (GDS-SF), Subjective Vitality Scale (SVS), Subjective Happiness Scale (SHS), Satisfaction With Life Scale (SWLS), and Satisfaction Index for the Third Age-Short Form (LSITA-SF). Results. Multiple regression analysis has shown that subjective vitality is a negative specific predictor of apathy in the middle adulthood, and depression is a positive universal predictor of apathy in both middle and late adulthood. Conclusion. The findings can be used in the Russian gerontopsychology to prevent apathy in persons with depressive symptoms and a low level of subjective vitality.
Adolescent Aggressiveness Towards Teacher: frequency, factors, consequences, prevention
Authors: Rean Artur A. , Egorova Anna V.
Published: October 2021

Background. The relevance of studying students’ aggressive behavior towards teachers lies in the fact that despite the ongoing discussion in society, modern research shows that this problem is not given enough attention. The Objective. is to consider the students’ aggressive behavior towards teachers: to assess the prevalence of this problem, to analyze the background of students’ aggressive behavior towards teachers, and to assess the consequences of such behavior. Design. The paper presents an analysis of foreign and Russian research on the problem of aggression towards teachers. In addition, attempts are made to find the causes of students’ aggressive behavior towards the teacher through the analysis of psychological theories. The article also offers recommendations for reducing and preventing aggression towards teacher on the part of students. Research results. The indicators that demonstrate prevalence of aggression towards teachers raise the concern that this problem has negative long-term consequences for the lives of students, teachers and educational institutions. The use of psychological theories, models and concepts in explaining the reasons of aggression in the teacher’s direction on the part of students, allows not only to determine the reasons for aggressive behavior, but also to consider this problem at different levels of the educational process. The influence of school climate on the victimization of teachers was considered and recommendations were made for the implementation of preventive measures. Conclusion. On the basis of the analysis conducted, the study presents possible directions for further study of this problem. In particular, it is necessary to study the prevalence of aggressive behavior towards teachers in Russian schools and to develop a set of preventive measures aimed at the elimination of aggression towards teachers.
CONSCIOUS SELF-REGULATION AS A METARESOURCE FOR ACHIEVING GOALS AND SOLVING THE PROBLEMS OF HUMAN ACTIVITY
Authors: Morosanovа Varvara I.
Published: October 2021

Background. In political, economic, social and environmental crisis conditions, a great importance is given to the investigation and search for the human psychological resources, which make it possible to successfully cope with usual and challenging life tasks in the conditions when the world order and the life styles drastically change. Objective of this article is to summarize the results of theoretical and empirical research for developing the resource approach to the study of the conscious self-regulation of human activity considered as a system of psychological means of consciously setting the goals and managing their achievement. Design. The resource approach provisions were substantiated theoretically and verified empirically in the laboratory of the self-regulation psychology of the Federal State Budgetary Scientific Institution “Psychological Institute of the Russian Academy of Education.” The studies were carried out on the large samples of schoolchildren, students, and professionals. Cognitive, personality and regulatory techniques included questionnaires and experimental tasks. Both cross-sectional and longitudinal design were applied. Results. The generalization of the empirical results made it possible to verify the developed scientific ideas of the conscious self-regulation of achieving goals as a system of the human universal and special regulatory resources, depending on the “globality” of the tasks they are intended for. The person’s regulatory competences implementing this system contribute to the productive aspects of achieving educational and professional goals. They also serve as a mechanism for mobilizing, coordinating, mediating and accumulating the entire palette of other individual resources and human reserves for solving various problems in human activity. Among these tasks are the personality self-development and self-education, professional self-determination, maintaining and increasing psychological well-being. The development of the conscious self-regulation resources contributes to successful learning and work in the context of rapid digitalization, serves as the basis for adaptation and formation of new self-organization of life, and also prevents acute stress reactions and negative emotional states under conditions of the coronavirus pandemic. Conclusions. Conscious self-regulation is a human meta-resource, since it not only makes a significant contribution to achieving the goals of practical activity, but also contributes to solution of the broader life tasks.