bluuebunny/crossref_metadata_2025 huggingface dataset:
Cloning and Expression of 3 Chymotrypsin-like Protease of SARS-CoV-2 in E. coli using pET28a Vector
Authors: Ly Vu Thi Duy , Giang Tran Thi Xuan , Trang Ngo Thu , Thai Dinh Nho , Nghia Phan Tuan , Loan Nguyen Thi Hong
Published: February 2023

The 3 chymotrypsin-like protease (3CLpro) of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is one of the primary targets for the development of antiviral drug therapies as it plays a critical role in viral replication. In this study, the gene encoding for SARS-CoV-2 3CLpro (918 bp) was amplified from the cDNA of the virus by polymerase chain reaction (PCR) and cloned into the pGEM-T vector. 3CLpro was then inserted into the expression vector pET28a at the end of the 6 histidine residue encoding sequence to form a fusion protein (6xHis-3CLpro). The 6xHis-3Clpro construct was successfully expressed in E. coli. The expression of 3CLpro was highest when E. coli BL21(DE3) RIL harboring pET28a-3CLpro vector was cultured in LB medium at 20 oC, induced by 1.0 mM Isopropyl thiogalactopyranosie (IPTG)  when cell density measured by optical density at 600 nm (OD600)  reached 0.7-0.8 and harvested after 24 hours of induction. The recombinant 3CLpro was purified by Ni-sepharose affinity chromatography under denaturation conditions. The purified 3CLpro showed to have a 41 kDa band on sodium dodesyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blotting using polyclonal anti-3CLpro antibody and hydrolyzed a fluorescent specific substrate of 3CLpro after renaturation.
Penjaja dan Wisata: Pedagang Kaki Lima di Pantai Padang, 2014-2019
Authors: Ayu Surinanda Siti , May Eni
Published: February 2023

Penelitian ini mengkaji kehidupan penjaja kaki lima di objek wisata Pantai Padang, Sumatera Barat. Tujuan dari penelitian ini adalah untuk menggambarkan dampak wisata Kota Padang terhadap kehidupan para penjaja kaki lima sebelum Covid-19. Metode penelitian menggunakan metode sejarah yang terdiri dari empat tahap; tahap pertama, pengumpulan data, kedua, tinjauan eksternal dan internal, interpretasi, dan penulisan hasil penelitian. Penelitian ini juga menggunakan sejarah lisan untuk mewawancarai orang-orang yang terkait dengan topik penelitian. Hasil penelitian menunjukkan bahwa potensi wisata Pantai Padang terkait erat dengan pengelolaan para penjaja kaki lima yang menjadi pendukung utama kepariwisataan.

Kata kunci: penjaja, Pantai Padang, wisata, covid-19, wawancara
The Conditions of the Mountains in the Verses of the Scenes of the Resurrection: Between Description and Simile
Authors: Hasan Murad
Published: February 2023

This study examines the linguistic depiction of mountains in the Doom’s day. The study, further, explores the continuity and  the diversity of the rhetoric  expressions and their relevance to the meaning they convey.
The Legal Intentions of the Contemporary Interpreters of the Holly verses
Authors: Ibrahim Muthanna
Published: February 2023

The Noble Qur’an came with many purposes, and among these objectives is what is related to legal rulings, between the Qur’an and Shari’a in general and in particular in terms of objectives, and the term “maqasid” is a modern term and is synonymous with the terms that I mentioned in the folds of the research such as (wisdom, reason, reason ... etc.). Understanding the purposes of the Sharia guarantees the soundness of thought from violating the intention of the text, and it is not possible to contemplate and properly understand the Qur’an without understanding its purposes and goals.

Thus, the main objective of Islamic Sharia is the formation of a secure Muslim society. Sharia is the comprehensive system that achieves people's happiness, fixes their affairs and achieves their interests in all aspects of life.
The Impact of Shafi’i Jurisprudence on the Egyptian Dar Al-Ifta - Issues of Purity, Prayer and Fasting
Authors: Khudair Emad
Published: February 2023

Purity, prayer, and fasting are different issues.  With every issue the research deals evidences presented by scholars concerning hadiths mentioned in the research.  The research, further higlights contemporary views of scholars concerning each issues. The research clarifies the correct opinion of each issues.  The research then showes the impact of Shafi’i jurisprudence.
Academic Licenses for the Hadiths of Nishapur and Isfahan
Authors: Ahmed Mohanad
Published: February 2023

The research deals with the scientific licenses of the hadiths    by Nishapur and Isfahan.  The study showes the role of women in memorizing the Prophet’s hadith in terms of endurance and performance. Among them is the endurance through scientific degrees, which is one of the important ways to know the degree of hadith by knowing the source and connection of the chain of transmission and why it emerged from the city of Nishapur. The study, furthermore, higlights the journey in seeking hadith, memorizing it and narrating it, and how they influenced the narration of a number of famous hadiths and texts written by outstanding  sheikhs like  Al-Mu’jam Al-Saghir and Al-Kabeer by Al-Tabarani and Al-Fitn by Na’im bin Hammad and other texts that were mentioned in the folds of this brief research.
The significance of the noun form of the command verb and its impact on legal rulings Examples of the verses of the Holy Quran
Authors: Khedr Ahmed
Published: February 2023

This research came under the title (The significance of the noun form of the command verb and its impact on legal rulings as examples from the verses of the Holy Qur’an). Formulas and their impact on legal rulings; Because the Holy Qur’an used many of these formulas to indicate the command of something, and the nature of the research required that I divide it into two chapters preceded by an introduction. And the terminology, and the second requirement showed the significance of the command and its meanings for fundamentalists, and the second topic mentioned in it the formula of the command verb’s noun and its impact on the legal rulings, and divided it into two requirements, in the first requirement I mentioned the command verb’s noun formulas contained in the Holy Qur’an, and the second requirement showed the command verb’s noun formulas and their impact on Sharia rulings in the Holy Quran, and concluded the research with the most important findings
Permissible monopoly in Islamic law
Authors: Rashid Ahmed , Rashid Sarah
Published: February 2023

Monopoly carries with it the seeds of doom and destruction because of the injustice, intransigence, high prices and affliction it causes, and the waste of freedom of trade and industry, and blocks the outlets for work and the doors of livelihood. What they possess until the price rises and they sell at a great profit without fear of Allah and care for the poor and needy of the nation. This phenomenon I witnessed in my wounded country, Iraq. Scholars and scholars have always warned about it, but few respond. Monopoly enjoys one of the pillars of the modern capitalist system, and a feature of economic dealings in most of the countries. Companies, if not in all of them, although it carries with it the seeds of destruction and destruction because of what it causes in injustice, intransigence, high prices, and affliction.
The significance of the utterance of the tools according to Al-Samin Al-Halabi (may God have mercy on him) in his book Umdat Al-Hafaz fi Tafsir Ashraf Al-Alfaz (d.
Authors: Khalaf Bashir , Ali Osman
Published: February 2023

ABSTRACT

   

                  Praise be to Allah, Lord of the Worlds, and prayers and peace be upon the Master of the Messengers, and upon his family and companions altogether.

This book is considered a source for linguists and interpreters at the same time, so the student of language vocabulary finds what he needs in it, as it meets a detailed analysis of the words of the Qur’an, their origins, derivations, development and uses, as well as the interpreter can use it in his interpretation, and this is the most important advantage of this book.

Among its advantages also: the author begins his book with an accurate index of the materials that he dealt with in his book, and this indicates its accuracy, good classification and organization, and also its richness in strange hadiths, Arabic evidence, and Arabic grammar research. With the linguistic truth of Al-Samin Al-Halabi (may  Allah  have mercy on him) in his book, which is: (pots - cups - paper), and these terms were stated by Al-Samin Al-Halabi (may  Allah  have mercy on him) in his book, and I took a share of the study in this research.
Lexical Density in EFL Indonesian Textbooks: A Comparative Analysis
Authors: Fadhil Ahmad , Gunawan Wawan , Wirza Yanty
Published: February 2023

The lexical density is known as the component determining the complexity level of the text. Hence, measurement of lexical density is needed to find out how challenging a particular text is to read.  However, it is important to know that the lexical density in English reading materials especially in Indonesian EFL textbooks between the Government Publisher and Non-Government Publisher is still less explored. This research will employ the Quantitative design to investigate how dense the lexical items are found in these two EFL Textbooks. The result showed that the lexical density of the non-government textbook is denser in all of the genres of the text compared to the government textbooks. In brief, by knowing the lexical density in the text, the teacher should have known what the appropriate text level should be taught to the students which is neither too low nor too high.
Cognitive behaviors in Indonesian-English translation: Exploring translation processes
Authors: Rustandi Andi
Published: February 2023

This present study investigated the cognitive behaviors in the processes of Indonesian-English translation. Two research questions were employed to find out; 1) what types of cognitive behaviors emerge in the translation processes, 2) and which types of cognitive behavior are the most dominant in the translation process? The data were taken from screen recording of translator activities in video supplemented by think-aloud protocols in TransCon6_ID.mp4 entitled "Panorama Sumba." The data were analysed qualitatively by following the steps: transcribing, identifying, classifying, and interpreting (Bailey, 2008). The result reveals that the translator uses several cognitive behaviors such as generating ideas, revising, elaborating, clarifying, retrieving, rehearsing, referencing or resourcing, and summarizing. However, the translator's most dominant behavior is referencing by seeking the dictionaries to solve the translation problem.
Perfil dos atendimentos dos serviços de urgência e emergência durante a pandemia pela Covid-19 no Brasil
Authors: Amaro Maria Eduarda Santos , Gomes Camila de Souza , Barbosa Gabriela Haydee Mayer de Figueiredo , Souza Grazyelle Ferreira de
Published: February 2023

Objetivo: Descrever as evidências científicas que abordam o perfil de atendimento dos serviços de urgência durante a pandemia da COVID-19 no Brasil. Métodos: Trata-se de uma revisão integrativa. O levantamento bibliográfico foi realizado de setembro a outubro de 2022, nas bases de dados: National Library of Medicine National Institutes of Health  (PubMed),  Scientific Eletronic Library Online (SciELO) e na Biblioteca Virtual de Saúde (BVS). Após a busca e análise dos artigos, foram selecionados 10 estudos. Resultados: Não houve mudança significativa na faixa etária dos usuários. A maioria dos estudos relatam maior atendimento a pessoas do sexo feminino, não havendo alteração no perfil de sexo quando relacionado ao período pré-pandemia. Apesar da diminuição no número de atendimentos, houve aumento proporcional de casos graves no pronto-socorro, concomitante a maiores taxas de internação, tempo e complicações pós-operatórias. Houve diminuição dos casos de infecção do trato gastrointestinal, pielonefrite obstrutiva aguda e conjuntivite. Por fim, houve aumento de casos de traumas domésticos e queixas respiratórias. Considerações finais: Destaca-se a necessidade de mais pesquisas sobre a temática abordada e espera-se que os resultados dessa pesquisa tragam à tona uma análise sobre os atendimentos realizados nos serviços de emergência durante a pandemia da COVID-19.
Associação entre depressão e ideação suicida em pacientes portadores de doenças crônicas
Authors: Gomes Ana Clara Ávila , Palma Ana Laura Xavier , Assis Daniele Silva , Assis Danielle da Conceição Resende , Pereira Júlia Kássia , Vidal Carlos Eduardo Leal
Published: February 2023

Objetivo: Verificar a associação de sintomas depressivos e ideação suicida entre portadores de doenças crônicas (DC).  Métodos: Trata-se de um estudo transversal em que foram avaliados portadores de DC nos ambulatórios de uma instituição de ensino superior. A avaliação foi feita com o instrumento clínico Mini International Neuropsychiatric Interview (MINI). A existência de associação entre as variáveis do estudo foi medida pelos testes de Qui-quadrado ou t de student, conforme o caso. O nível de significância foi de 5%. Resultados: A amostra foi composta por 345 entrevistados, com idade média de 59,9± 13,2 anos, sendo a maioria do sexo feminino (55,9%), religião católica (82,5%), casados (51,6%) e leucodermos (51,9%). Isoladamente, a hipertensão arterial foi a doença crônica mais identificada. A presença de depressão e ideação suicida foi verificada em um terço dos entrevistados. Houve associação positiva de depressão em mulheres, diabéticos e pacientes com mais de 10 anos de doença. Por outro lado, foi identificado como fator protetor da depressão e da ideação suicida, as variáveis estado civil casado e ser portador de apenas uma DC.  Conclusão: Os resultados indicaram que a associação entre depressão e ideação suicida em doentes crônicos foi superior ao observado na população geral.
On the manner of painting the tiles made in St. Petersburg in the first half of the 18th century
Authors: Реброва Р. В.
Published: February 2023

В статье впервые исследуются изразцы первой половины XVIII в., сделанные петербургскими мастерами для печей Летнего и Зимнего дворцов Петра I, Екатерингофа, Меншиковского дворца, Кадриорга, Рундальского замка, и археологический материал из раскопок в Санкт-Петербурге. Ставится вопрос о существовании единого стиля в росписи изразцов среди гончарных мастерских в первой половине XVIII в. и его происхождении.

The article examines for the first time ceramic tiles made in the first half of the 18th century for the stoves at Peter I's Winter and Summer palaces, as well as for Menshikov's palace, Kadriorg, Catherinehof, Rundale palace, and some archaeological finds in St. Petersburg. The author also investigates whether a single style in painting tiles did in fact exist among the potter's studios of the first half of the 18th century, and if yes, how it came to be.
A technological study of archaeological fragments of tiles at the Novodevichy Convent in Moscow
Authors: Шиманова М. А. , Лобзова Р. В.
Published: February 2023

В статье представлены исследования фрагментов изразцов, которые с высокой долей вероятности можно отнести к одному печному набору, обнаруженных во время ремонтно-реставрационных работ в Певческих палатах Новодевичьего монастыря в Москве. Приведены результаты микроскопических исследований образцов, электронно-микроскопический и рентгеноспектральный анализы глазури и черепка фрагментов изразцов. Представлены аналоги западноевропейских печей, которые могли бы служить прототипом одной из несохранившихся печей, бытовавшей в Новодевичьем монастыре в Москве.

The article presents a study of tile fragments which are highly likely to have belonged to a single set for a stove. The fragments were discovered during the restoration of the Choir Chambers (Pevcheskie Palaty) of Moscow's Novodevichy Convent. We provide data of the microscope study of the samples, as well as the electron-microsсopic and X-ray spectroscopic analysis of the glazing and shards of tile fragments. Also presented are the European stoves which might have served as a prototype of one of the now destroyed stoves which once stood in a convent building.
Local 12th to 18th century ceramics in the collection of Pereslavl Museum-Reserve: on its attribution and use in studies of architectural monuments
Authors: Шадунц Е. К.
Published: February 2023

Архитектурная керамика XII-XVIII вв. (плитки пола, простые и фигурные кирпичи, лемех для покрытия глав) из фондов Переславского музея-заповедника не выделена в отдельную коллекцию. Предметы, поступившие в музей во время археологических и реставрационных работ в Переславле-Залесском, связаны с памятниками архитектуры города. Целью работы являются обзор, уточнение атрибуции и первая публикация предметов из музейной коллекции. Сделаны выводы о первоначальном виде пола Спасо-Преображенского собора XII в., выполненного мастерами Юрия Долгорукого. Археологические находки подтверждают наличие собственного керамического производства в Переславле, которым занимались мастера гончарного дела

12th-17th century architectural ceramics, such as floor tiles, regular and ornate bricks, and the lemekh (shingle roofing), do not form a separate collection at the Pereslavl Museum-Reserve. All of these items were added to the museum collections in the course of archaeological and restoration works in the town, and are related to Pereslavl's monuments of architecture. The article aims to provide an overview and a more precise attribution and, for the first time, make some of the collection items public. The author offers some suggestions on what the original design of the floor made by Yuri Dolgoruky's team for the 12th century Transfiguration Cathedral might have looked like. Archaeological finds confirm that Pereslavl had a ceramics workshop of its own run by master potters.
On the history of restoring the ceramic decor at the Resurrection cathedral, the New Jerusalem monastery, in 1923
Authors: Баранова С. И.
Published: February 2023

В статье представлены материалы, связанные с реставрацией под руководством А. В. Филиппова керамического (изразцового) декора Воскресенского собора Ново-Иерусалимского монастыря в 1923 г. Она явилась продолжением реставрации 1915 г., когда А. В. Филипповым был «промыт» изразцовый наличник собора. Отработанные методики реставрации по удалению слоев закраски были использованы в 1923 г. более широко, что положило начало дальнейшей реставрационной истории памятника. На основании выявленных документов приводятся сведения о подходах к реставрации уникального декора, включающие его исследование

The article presents some sources dealing with the restoration of the ceramic (tiled) decor of the Resurrection cathedral of the New Jerusalem monastery. Led by A. V. Filippov, the restoration took place in 1923 and came as a continuation of the 1915 effort, when A. V. Filippov washed clean a piece of tiled window lining. The methods of peeling off the old paint, developed in 1915, were used in 1923 on a wider basis, which launched a new stage in the monument's restoration history. The documents we have found contain more details on how studying and restoring the original decor could be approached.
Dutch, Russian and Chinese ceramic tiles and the German glazed tiles in early St. Petersburg
Authors: Андреева Е. А.
Published: February 2023

Для Петра I Санкт-Петербург был одной из реформ, тем местом, в котором он пробовал все новое и отметал неподходящее. Это касалось и отделочных решений. В статье рассказывается, когда, как и в каком царском дворце впервые появилась голландская расписная фаянсовая плитка. На основании выявленных документов приводятся неизвестные ранее сведения об отделке голландской плиткой интерьеров домов знати и казенных построек. Повествуется также о попытке налаживания в Петербурге производства керамической плитки с подглазурной росписью. Кроме того, дается ответ на вопрос, поставленный в статьях И. И. Сергеенко: были ли доставлены в Петербург заказанные русским царем в Пекине фарфоровые печи.

Peter the Great saw St. Petersburg as one of his reforms, as a testing ground for novelties which could then be accepted or discarded. This was also true for choices of decor. The article focuses on when, under what circumstances and which particular royal palace first featured Dutch painted earthenware tiles. The documents we have discovered provide previously unknown information on how Dutch tiles were used to decorate the interiors of both private aristocratic homes and public buildings. They also tell the story of an attempt to set up local production of painted and then glazed tiles in St. Petersburg. In addition, we have found an answer to the question originally asked by I. I. Sergeyenko on whether the earthenware stoves ordered by the Russian tsar in Beijing were actually delivered to St. Petersburg.
Neglected Growing Skull Fracture: Details on Peroperative Findings and Surgical Repair
Authors:   Department of Neurosurgery, Faculty of Medicine, National Institute Mongi Ben Hmida of Neurology of Tunis, University Tunis al Manar, Road Jebbari 1007, Tunisia, A Khansa , BA Kerima ,   Department of Neurosurgery, Faculty of Medicine, National Institute Mongi Ben Hmida of Neurology of Tunis, University Tunis al Manar, Road Jebbari 1007, Tunisia, B Imen ,   Department of Neurosurgery, Faculty of Medicine, National Institute Mongi Ben Hmida of Neurology of Tunis, University Tunis al Manar, Road Jebbari 1007, Tunisia, K Jalel ,   Department of Neurosurgery, Faculty of Medicine, National Institute Mongi Ben Hmida of Neurology of Tunis, University Tunis al Manar, Road Jebbari 1007, Tunisia
Published: February 2023

Growing Skull Fracture (GSK) is a rare but significant complication of pediatric head trauma. It commonly develops after a head trauma with a linear skull fracture and an underlying dural tear. Delayed diagnosis and improper management can lead to severe complications. Few reports provide details on peropeartive findings and surgical management of GSF. Herein we report the case of a neglected growing skull fracture in a 2-year-old infant who suffered from an abuse head trauma at the age of three months. A progressive bulging at the site of the fracture was neglected by the family for months. CT scan of the brain showed gliotic brain tissue herniated through a large ragged skull defect. Surgery was indicated and the goals of operation were to remove safely nonviable herniated brain tissue and to protect the neural elements by restoring dural and bone defect. Surgery should be performed acutely in children with GSF to reduce the morbidity and improve outcome.
Role of CRISPR Cas-9 in Thyroid Cancer
Authors:   General Physician, Khairpur, Pakistan, S Sial
Published: February 2023

The regularly clustered and interspersed short palindromic repeats CRISPR are used for the treatment against many diseases. It is also widely used in the field of medicine. It can speedily screen the entire genome also facilitates the regulation of gene therapy for the certain diseases due to its strong specificity and high efficiency. CRISPR-CAS 9 can be used in the different field of tumor research for changing the genome to explore the mechanism of tumor development and. It is used for the treatment of tumors and knocks out specific genes.
Primary Hydatid Cyst of Gluteal Muscle, an Anusual Location: A Case Report and a Literature Review
Authors:   Department of Visceral Surgery, Mohammed Military Hospital, Rabat, Morocco, M Lamghari , EM Aboulfeth ,   Department of Visceral Surgery, Mohammed Military Hospital, Rabat, Morocco, M Sabur ,   Department of Visceral Surgery, Mohammed Military Hospital, Rabat, Morocco, A Maazouz ,   Department of Visceral Surgery, Mohammed Military Hospital, Rabat, Morocco, IE Azzoui ,   Department of Visceral Surgery, Mohammed Military Hospital, Rabat, Morocco, M Najih ,   Department of Visceral Surgery, Mohammed Military Hospital, Rabat, Morocco, HE Kaoui ,   Department of Visceral Surgery, Mohammed Military Hospital, Rabat, Morocco, A Bounaim ,   Department of Visceral Surgery, Mohammed Military Hospital, Rabat, Morocco
Published: February 2023

Introduction: Hydatid disease is a zoonosis caused by an infection with the larvae of the tapeworm echinococcus granulosus, it mostly involves liver and lungs but it may exceptionally affect muscle. Case Report: we report the case of a 22 years old man who was admitted to our surgical clinic with a primary hydatid cyst in gluteal muscle diagnosed by clinic examination, imaging and serological testing. The treatment was a complete pericystectomy and chemotherapy by antiparasit drugs. Discussion: Hydatid disease it‘s an endemic disease in sheep-producing regions, In human, this disease involves usually the liver and the lungs and exceptionally the muscle. The diagnosis may be challenging, as it should consider arguments such as history, physical examination, imaging and serological testing. The best treatment is pericystectomy with perioperatory chemotherapy to reduce risk of occurrence. Conclusion: The hydatid cyst of gluteal muscle is exceptional even in endemic area, the diagnosis may be challenging and the surgery is the gold standard of treatment.
A Case Report: Massive Spontaneous Hemorrhage of Neurofibromatosis Type 1 on Upper Back
Authors:   Division of Plastic Surgery, Department of Surgery, Chi-Mei Medical Center, Taiwan, CC Yeh
Published: February 2023

Neurofibromatosis type 1 (NF1) (von Recklinghausen’s disease) is an autosomal dominant disorder characterized by café-au-lait spots, pigmented hamartomas of the iris, and multiple neurofibromas. Patients can present with hemorrhage secondary to trauma or rarely with spontaneous hemorrhage. We report a 42-year-old man with long-term history of a giant neurofibroma on his back who suffered from spontaneous hemorrhage. Series examinations and treatments were given to stop bleeding and eventually to heal the wound.
Synthesis and Characterization of a Novel Polymorph of Glimepiride
Authors:   Indoco Remedies Ltd, R92/93, TTC Industrial Area, Rabale, India, S Jadhav , A Gosar ,   Indoco Remedies Ltd, R92/93, TTC Industrial Area, Rabale, India, G Mandawad ,   Maharashtra Udaygiri College, Udgir.413517.SRTM University, Nanded, India, M Patil ,   Indoco Remedies Ltd, R92/93, TTC Industrial Area, Rabale, India
Published: February 2023

Polymorphism in drug substances is a phenomenon that leads to a change in the efficacy of drugs due to changes in their physicochemical properties, particularly solubility and bioavailability. Glimepiride has two polymorphs described in the literature Glimepiride form I and Glimepiride form II.A new crystalline form-III was prepared by recrystallization from a Glimepiride form-I by using an N-methyl-2-pyrrolidone solvent system and ethyl acetate and acetone solvent mix 50/50 v/v. The solubility and melting properties of the novel polymorph are significantly different from the reported two polymorphs. A novel polymorph has been evaluated by using an X-ray diffractometer and differential scanning calorimeter, Thermogravimetric techniques, and image analysis. The crystal structure of Glimepiride form III is more thermodynamically stable than the previously reported form I and form II. A new crystalline form of glimepiride with a characteristic melting point of 276.2°C, a distinguished marker 2θpeak at 6.7°, 30.5°, and marker peak of form I and II in the region of 2θ 8-12.5 not observed in diffractogram of novel Glimepiride polymorph III which resulting in a unique Diffractogram pattern of form III.IR spectra show that the absorption band shows at 3325.28cm-1 which is different than reported for Glimepiride polymorph I absorption at 3290 and 3370 cm-1 and for Glimepiride form II absorption at 3370 and 3100 cm-1
Polyuria, Polydipsia and Papules in a 9-Year-Old Girl: A Case Report
Authors:   Department of Pediatrics, Inova L. J. Murphy Children’s Hospital, USA, H Busch , LM Nashed ,   Department of Pediatrics, Inova L. J. Murphy Children’s Hospital, USA, O Neacsu ,   Pediatric Specialists of Virginia, Department of Endocrinology, USA, RA Silverman ,   Department of Pediatrics, Medstar Georgetown, USA
Published: February 2023

Eruptive xanthomas can be cutaneous manifestations of hypertriglyceridemia but are commonly misdiagnosed as molluscum contagiosum. They appear as yellow papules without an umbilicated surface and have a broad differential. One benign etiology is papular acrodermatitis of childhood (Gianotti-Crosti syndrome) that may develop after several different viral illnesses and may be of similar size, number and location as eruptive xanthomas. Juvenile xanthogranulomas are another diagnostic differential but are more often a single lesion. When multiple xanthogranulomas are present, the clinician should look for NF-1 associated with hematologic malignancy. Pruritus is not a typical feature and, if present, should prompt further investigations, specifically to rule out cholestasis. Finally, xanthomas may also present with newly diagnosed diabetes mellitus as insulin is a key component of lipid metabolism. In such cases, eruptive xanthomas should be expected to resolve with adequate diabetic control, when presenting concomitantly; however, adult patients may require medical therapy.
Modern aspects of foreign trade policy of the Russian Federation and its export potential in the grain market
Authors: Nagovitsyna E. V. , Tusin D. S.
Published: February 2023

The article assesses the importance of the Russian Federation for global agricultural markets, describes relevant risks associated with the conflict in Ukraine and proposes ways to address the challenges of exporting Russian products to international markets in order to prevent famine and social problems in the world. The study includes an overview of Russian and foreign specialised literature, which allowed to systematize the ways to achieve the goal set that had already been proposed and develop new ones. Logical, economic and statistical methods as well as the methods of synthesis, system and SWOT analysis served as a basis for the study. Using the methods of theoretical analysis, the authors identified specific features of the Russian and global markets’ advancement. Economic and statistical methods provided an opportunity to describe trends and factors that determine the direction of the grain market’s development. Fundamental food security problems as well risks associated with the dependency of various states on the imports of feed and fertilizers from Ukraine and the Russian Federation were examined. A conclusion according to which the ambiguous geopolitical situation can hinder food exporting to many countries was made. The importance of restructuring the logistics system of grain supplies at the current stage was proved, and measures aimed at countering critical challenges of and threats to exporting agricultural products from the Russian Federation were proposed.
Features of event content and evaluation of significant life situations in persons with different levels of personal maturity
Authors: Andryushkova N. P.
Published: February 2023

The article examines personal maturity as a complex multicomponent phenomenon that can reach various levels of development. The relevance of the study of personal maturity through significant events of a person’s life path is noted. In order to identify the attitude towards the most significant life events and the specifics of interaction with the life situation, an empirical study was conducted and involved 277 people 25 to 40 years of age that represent the fields of education, medicine, service and trade, and mining industry. The subjects were divided into 2 groups according to their level of personal maturity and infantilism as polar characteristics. Based on the results of the study, the author points out significant differences in the experience and description of life events as well as the definition of significant life situations among subjects with different levels of personal maturity.
Reasons for the growth of destructive fear during the transformation of individual components of actual self-perception
Authors: Basimov M. M.
Published: February 2023

The article presents a causal view on the influence that components of the actual self-perception, “Suppressed – independent” and “Indifferent (indifferent) – included,” have on the transformation of destructive fear in a stressful life situation. None of the coefficients of linear correlation between the indicator of destructive fear and the components of actual self-perception exceed 0.25 in absolute value; they are too weak to be noted. However, in the model for quarts of the independent variable, two strong relationships were found through the use of the author’s method, showing the non-linear nature of destructive fear. Linear models are unacceptable in this case, since they can only distort the results extremely and lead to erroneous conclusions and interpretations. The author of the article provides descriptions of these dependencies as well as their visual graphical representation and explains in what way they would most likely be assessed using the traditional approach.
Research of problems and prospects of development of public control in the information and communication space
Authors: Okolyshev D. A.
Published: February 2023

The article is devoted to the study of problems and prospects of public control development in the information and communication space. An overview of studies in the interdisciplinary field of knowledge that are dedicated to potential threats in public political discourse affecting the consciousness of social groups is provided. The degree of elaboration regarding the issues facing the implementation of public control processes in the public administration system is assessed. The main issues facing the implementation of public control in information and communication networks are identified. It is substantiated that in the long term, intelligent systems will become a fundamental part of the communication flows analysis system. Based on the research conducted, a model of public control has been developed and tested in relation to the results of monitoring the provision of quality education. The study has established the strategic importance and advantage of using intelligent semantic analysis systems for the implementation of public control. It has been identified that fabricated information is not influenced by territorial affiliation. The object for which manipulation is intended and the target that affects the object by direct or indirect means, depending on the influence factors and the current socio-economic situation of the target subjects, are of primary importance. The author stresses that the study of specifics of the implementation of state policy in the public control system in conjunction with the assessment of municipal specifics is relevant and will serve further implementation of a decentralized system of public control. Based on the results of the study, a conclusion is made about the potential role of the state in the information and communication environment in the following years.
Modular Synthesis of Polar Spirocyclic Scaffolds Enabled by Radical Chemistry
Authors: Anwar Khadijah , Aguilar Troyano Francisco José , Abazid Ayham H. , El Yarroudi Oumayma , Funes-Ardoiz Ignacio , Gómez-Suárez Adrián
Published: February 2023

Exploration of three-dimensional structural space has become crucial for the development of novel bioactive molecules. In this context, polar spirocycles have emerged as key scaffolds due to their enhanced 3D character and well-defined spatial orientation. Herein, we report the development of a highly modular strategy to access beta-spirocyclic pyrrolidine derivatives from readily available starting materials, i.e., cyclic ketones and amino or oxamic acids. The sequence proceeds through a straightforward Knoevenagel condensation, followed by a domino Giese-type reaction/base-mediated cyclisation process, delivering a broad scope of polar spirocyclic scaffolds in good to excellent yields. The products can be readily diversified to access a wider range of spirocyclic cores (such as lactams or succinimides), thus increasing the versatility of our method to gain rapid access to libraries of potential drug-like molecules.
Critical Fluctuations in Liquid-Liquid Extraction Organic Phases Controlled by Extractant and Diluent Molecular Structure
Authors: Bonnett Brittany , Sheyfer Dina , Wimalasiri Pubudu , Nayak Srikanth , Lal Jyotsana , Zhang Qingteng , Seifert Soenke , Stephenson Brian , Servis Michael
Published: February 2023

Extractant aggregation in liquid-liquid extraction organic phases impacts extraction energetics and is related to the deleterious efficiency-limiting liquid-liquid phase transition known as third phase formation. Using small angle x-ray scattering, we find that structural heterogeneities across a wide range of compositions in binary mixtures of malonamide extractants and alkane diluents are well described by Ornstein-Zernike scattering. This suggests that structure in these simplified organic phases originates from the critical point associated with the liquid-liquid phase transition. To confirm this, we measure the temperature dependence of the organic phase structure, finding critical exponents consistent with the 3D Ising model. Molecular dynamics simulations were also consistent with this mechanism for extractant aggregation. Due to the absence of water or any other polar solutes required to form reverse-micellar-like nanostructures, these fluctuations are inherent to the binary extractant/diluent mixture. Our previous work found pseudobinary critical fluctuations near the critical point for more complex organic phases with extracted polar solutes, including water, acid and metal ions. Taken together, these results suggest this mechanism for explaining organic phase aggregation may dominate over a wide range of conditions encountered in practical liquid-liquid extraction organic phases. We also show how the molecular structure of the extractant and diluent modulate these critical concentration fluctuations by shifting the critical temperature: critical fluctuations are suppressed by increasing extractant alkyl tail lengths or decreasing diluent alkyl chain lengths. This is consistent with how extractant and diluent molecular structure are known to impact metal and acid loading capacity in many-component LLE organic phases, suggesting phase behavior of practical systems may be effectively studied in simplified organic phases. Overall, the explicit connection between molecular structure, aggregation and phase behavior demonstrated here will enable the design of more efficient separations processes.
THE MEMORIZED EFFECTIVENESS OF THE QUR’AN THROUGH THE TIKRAR TAFSIR METHOD OF INCREASING THE SPIRITUAL INTELLIGENCE OF FEMALE STUDENTS
Authors: . Suwarti , Trisanti Lita
Published: February 2023

Female students’ spiritual intelligence can be enhanced by applying the tikrar method of repeating scripture 20 times repeated by providing an interpretation for understanding the content of a memorized Qur’an scripture using an indicator of spiritual intelligence. The study aims to know the traditional effectiveness of the Qur’an through the tikrar tafsir method of increasing the spiritual intelligence of female students in Rumah Qur’an Ifititah Purbalingga. The experimental sample removal technique uses impressive sampling—research ten subjects of female students in Rumah Qur’an Iftitah Purbalingga. The data was collected using a spiritual intelligence scale instrument with the treatment given in the form of the tikrar interpretation method. The results showed that the tikrar interpretation method in memorizing the Qur’an effectively increased spiritual intelligence. This was indicated by an increase in the mean score on the pre-test (score = 16.1) and post-test (score = 25.3 ) with an average difference of 9.2. From the results of the data analysis test using the paired sample t-test technique, it was obtained that the value of p = 0.000 (p <0.05). Results of the data analysis using the t-test technique, the value is from p=0,000 (p<0,05). That value implies that there is a significant influence on the difference in treatment given to each variable.
CONSUMERS’ PREFERENCE FOR LOCAL RICE BRANDS IN IBADAN METROPOLIS, NIGERIA
Authors: Obayelu Oluwakemi Adeola , Agbohin Janet Abiola , Obisesan Omobolaji Olubukunmi
Published: February 2023

Despite a self-sufficiency in rice production in Nigeria, there is a huge supply deficit of local rice, which is augmented by importation. This shows a low demand for locally produced rice and a high importation bill for rice. This study therefore assessed consumers’ attitude to and preference for locally grown rice in Ibadan metropolis, Nigeria. A multi-stage sampling procedure was used to select three hundred consumers using a questionnaire. Data were analysed using descriptive statistics, Likert scale and double-hurdle regression. Consumers spent about a third (31%) of their monthly food expenditure on rice consumption. Preference for local rice was lower (48%) than imported rice (52%). Cleanliness and absence of stones were major attributes consumers consider when purchasing local rice brands. The attitude towards consumption of local rice was very limited among the consumers. A marginal increase in household expenditure on rice reduces the probability of a consumer’s preference for local rice brands. Policy thrusts aimed at mitigating spikes in price of local rice will impact its consumption positively.
ASSESSMENT OF PRECISION NUTRIENT MANAGEMENT PRACTICES ON CROP GROWTH, PRODUCTIVITY, AND PROFITABILITY OF MAIZE GROWN DURING WINTER IN CENTRAL TERAI, NEPAL
Authors: Pant Dipendra , Amgain Lal Prasad , Paudel Asmita , Guragain Grishma
Published: February 2023

To assess the effect of precision nutrient management practices on the growth, productivity, and profitability of different maize cultivars grown during winter, a field experiment was accomplished at Khairahani, Chitwan, during 2018/19. The field experiment was laid out in split-plot design with three replications for two maize cultivars as main-plot treatments (V1-Rampur Composite and V2-Rampur Hybrid-6) and four precision nutrient management practices as sub-plot treatments (T1-Blanket recommendation (60:30:30 kg NPK ha-1), T2-SSNM based Nutrient Expert-Maize model recommended dose (110:27:33 kg NPK ha-1), T3-Farmers’ fertilizer practices (82.5:34.5:15 kg NPK ha-1), T4-LCC based Nitrogen and farmers’ practice-based P and K). The experimental finding indicated that the overall performance of the Rampur Hybrid-6 cultivar was superior to Rampur Composite in terms of yield and yield attributes. SSNM-based NE-Maize model was superior to other nutrient management practices on growth attributes viz. plant height, leaf area index and crop growth rate, yield attributing characters viz. total number of kernels cob-1, number of rows cob-1, and kernel yield. SSNM-based NE- Maize model recorded the best performance with the highest BC ratio (2.47) followed by LCC-based Nitrogen over the farmer’s fertilizer practice-based P and K (2.42).
RECENT TRENDS ON ALLOCATION AND UTILIZATION OF BUDGET FOR AGRICULTURE SECTOR IN NEPALESE BUDGETARY PLAN
Authors: Pandit Samyam , Dhakal Shiva Chandra
Published: February 2023

A budget is a financial plan that plays a pivotal role in the functioning of the state. This study looks at recent changes in the distribution and use of the budget for the agriculture sector during the last ten fiscal years. Following a review of the numerous journals, publications, budgets, and economic surveys available on the Ministry of Finance websites, the secondary data is presented and analyzed using STATA 13 and Microsoft Excel. Results showed that agriculture’s share of the total gross domestic product has declined from 35.68 percent to 25.80 percent over the past ten years, while the national gross domestic product has increased by NRs. 2738.98 billion. Despite the country’s growing overall gross domestic product, the agriculture sector only received an average of 3 percent of the entire budget, which is below par with its contribution to the country’s gross domestic product i.e., 30 percent. However, the agriculture sector’s contribution is declining, which shows that other sectors (such as industry and services) are expanding. Additionally, the agriculture sector is growing as a result of increased agricultural production in comparison to previous years. More budget should be allocated to the agriculture sector in the upcoming fiscal years as results indicate that it considerably contributes to the nation’s overall gross domestic product.
SHARE OF AGRICULTURE ON EMPLOYMENT, INCOME AND TRADE
Authors: Gautam Susan , Dhakal Shiva Chandra
Published: February 2023

Nepal is a country having diverse range of agricultural life. Agriculture is a main source of income and employment. This paper assesses the current scenario and the trend of share of agriculture on employment, income and trade in Nepal. Secondary data from various sources were used for study. Statistical techniques including descriptive statistics and trend analysis was used. Share of agriculture on employment and income is decreasing and import of agricultural commodities is drastically heavy than the export of such products. The proportion of population engaged in agriculture has shown a sharp decline from 82.33% in 1991 to 64.38% in 2019. Agriculture made up 48.80 percent of the gross domestic product (GDP), in 1990 where share has been gradually decreasing and was a mere 23.13 percent in 2020. In 2019/20, total merchandise exports and imports stood at Rs. 97.71 billion and Rs. 1196.80 billion respectively where trade deficit stood at Rs. 1099.09 billion which is 27.9 percent of GDP. Nepal is shifting from agriculture-driven economy to industrial as well as remittance driven economy. Formulation and implementation of appropriate agriculture related policy to enhance agriculture for boosting up Nepalese economy is recommended.
Actual Guidance Is Enough
Authors: Fischer Stefan
Published: February 2023

In a recent article, Sharadin and van Someren Greve call into question an idea many philosophers take to be platitudinous, namely that deontic evaluation is capable of action guidance. In this critical note, I argue that their skeptical worries are unwarranted. The central problem in their argument, I claim, is a too unrestrained account of "actual guidance". According to  this account, an agent's deontic evaluation of an action alternative that bears the result that the action in question is both right and wrong would actually guide the agent with respect to whether or not to perform it. This, I argue, is implausible because it does not help the agent to settle the issue she is interested in. I propose an alternative account of actual guidance, according to which a deontic evaluation actually guides an agent with respect to whether or not to perform an action, X, if, and only if, it changes the agent's perception of the relative weight of the pros and cons of X-ing. This understanding of "actual guidance", I claim, is coherent, natural, and better captures our pre-theoretical sense of what it means for a consideration to help an agent to settle the question of whether or not to perform an action. However, since Sharadin's and van Someren Greve's skeptical endeavor entirely depends on the claim that we could not understand "actual guidance" in this way, their argument never really gets off the ground. I conclude that the authors do not provide a sufficient basis for doubting that deontic evaluation is capable of doing what it is for.