bluuebunny/crossref_metadata_2025 huggingface dataset:
Chinese Medicine as an Adjunctive Treatment for Gastric Cancer: Methodological Investigation of meta-Analyses and Evidence Map
Authors: Lu Cuncun , Ke Lixin , Li Jieyun , Wu Shuilin , Feng Lufang , Wang Youyou , Mentis Alexios Fotios A. , Xu Peng , Zhao Xiaoxiao , Yang Kehu
Published: January 2022

Background: Many meta-analyses (MAs) on Chinese medicine (CM) as an adjunctive treatment for gastric cancer have been published in recent years. However, the pooled evidence reported in MAs and their methodological quality remain unknown. Therefore, we designed a study to comprehensively evaluate and summarize the current evidence of CMs for gastric cancer in published MAs.

Methods: A systematic search on MAs published in English from inception to 1st September 2021 was conducted in PubMed and Embase. The AMSTAR-2 tool was used to evaluate the methodological quality of the included MAs, and the results of the quality assessment were visualized using the evidence mapping method. Stata 17/SE was used for statistical analysis (Registration number: INPLASY202190005).

Results: A total of 20 MAs (16 pairwise and 4 network MAs) were included from 118 records. These MAs were published in 14 journals from 2013 to 2021, with the number of patients and trials ranging from 688 to 6,857, and from 10 to 85, respectively. A large number of CMs (e.g., AiDi, FuFangKuShen, and HuaChanSu) in combination with chemotherapy for gastric cancer were identified among the included MAs. According to the pooled results reported in MAs, when compared to chemotherapy alone, CMs in combination with chemotherapy not only improve various outcomes on efficacy (e.g., objective response rate, quality of life) but also reduce various adverse reactions (e.g., leucopenia, nausea and vomiting). Only 2 MAs were low in terms of the overall methodological quality, while the other 18 MAs were all critically low. The methodology was required to be advanced significantly, mainly involving: study protocol and registration, explanation for the inclusion of study design, list of excluded studies with justifications, adequate details of included studies, reporting on funding sources of primary studies, and evaluation of the potential impact of risk of bias. In addition, MAs that received funds support (β = 2.68; 95%CI: 0.40 to 4.96; p = 0.024) or were published in journals with higher impact factor (β = 2.81; 95%CI: 0.69 to 4.92; p = 0.012) had a higher score on the overall methodological quality in the univariate analysis, but the results were not statistically significant according to the multivariate analysis.

Conclusion: Combining CMs with chemotherapy can potentially improve clinical outcomes and reduce the relevant adverse effects in patients with gastric cancer. However, the methodological quality of relevant MAs requires significant improvement, and the current evidence needs to be validated through multinational trials that are well-designed and have a large sample size.
Emerging Therapeutic Strategies for Attenuating Tubular EMT and Kidney Fibrosis by Targeting Wnt/β-Catenin Signaling
Authors: Hu Lichao , Ding Mengyuan , He Weichun
Published: January 2022

Epithelial-mesenchymal transition (EMT) is defined as a process in which differentiated epithelial cells undergo phenotypic transformation into myofibroblasts capable of producing extracellular matrix, and is generally regarded as an integral part of fibrogenesis after tissue injury. Although there is evidence that the complete EMT of tubular epithelial cells (TECs) is not a major contributor to interstitial myofibroblasts in kidney fibrosis, the partial EMT, a status that damaged TECs remain inside tubules, and co-express both epithelial and mesenchymal markers, has been demonstrated to be a crucial stage for intensifying fibrogenesis in the interstitium. The process of tubular EMT is governed by multiple intracellular pathways, among which Wnt/β-catenin signaling is considered to be essential mainly because it controls the transcriptome associated with EMT, making it a potential therapeutic target against kidney fibrosis. A growing body of data suggest that reducing the hyperactivity of Wnt/β-catenin by natural compounds, specific inhibitors, or manipulation of genes expression attenuates tubular EMT, and interstitial fibrogenesis in the TECs cultured under profibrotic environments and in animal models of kidney fibrosis. These emerging therapeutic strategies in basic researches may provide beneficial ideas for clinical prevention and treatment of chronic kidney disease.
Development of Mechanical Stability in Late-Stage Embryonic Erythroid Cells: Insights From Fluorescence Imaged Micro-Deformation Studies
Authors: Delgadillo Luis F. , Huang Yu Shan , Leon Sami , Palis James , Waugh Richard E.
Published: January 2022

The combined use of fluorescence labeling and micro-manipulation of red blood cells has proven to be a powerful tool for understanding and characterizing fundamental mechanisms underlying the mechanical behavior of cells. Here we used this approach to study the development of the membrane-associated cytoskeleton (MAS) in primary embryonic erythroid cells. Erythropoiesis comes in two forms in the mammalian embryo, primitive and definitive, characterized by intra- and extra-vascular maturation, respectively. Primitive erythroid precursors in the murine embryo first begin to circulate at embryonic day (E) 8.25 and mature as a semi-synchronous cohort before enucleating between E12.5 and E16.5. Previously, we determined that the major components of the MAS become localized to the membrane between E10.5 and E12.5, and that this localization is associated with an increase in membrane mechanical stability over this same period. The change in mechanical stability was reflected in the creation of MAS-free regions of the membrane at the tips of the projections formed when cells were aspirated into micropipettes. The tendency to form MAS-free regions decreases as primitive erythroid cells continue to mature through E14.5, at least 2 days after all detectable cytoskeletal components are localized to the membrane, indicating continued strengthening of membrane cohesion after membrane localization of cytoskeletal components. Here we demonstrate that the formation of MAS-free regions is the result of a mechanical failure within the MAS, and not the detachment of membrane bilayer from the MAS. Once a “hole” is formed in the MAS, the skeletal network contracts laterally along the aspirated projection to form the MAS-free region. In protein 4.1-null primitive erythroid cells, the tendency to form MAS-free regions is markedly enhanced. Of note, similar MAS-free regions were observed in maturing erythroid cells from human marrow, indicating that similar processes occur in definitive erythroid cells. We conclude that localization of cytoskeletal components to the cell membrane of mammalian erythroid cells during maturation is insufficient by itself to produce a mature MAS, but that subsequent processes are additionally required to strengthen intraskeletal interactions.
Imaging of Fibrosis in Chronic Pancreatitis
Authors: Yamashita Yasunobu , Ashida Reiko , Kitano Masayuki
Published: January 2022

Chronic pancreatitis (CP) describes long-standing inflammation of the pancreas, which leads to irreversible and progressive inflammation of the pancreas with fibrosis. CP also leads to abdominal pain, malnutrition, and permanent impairment of exocrine/endocrine functions. However, it is difficult to assess CP pathologically, and imaging modalities therefore play an important role in the diagnosis and assessment of CP. There are four modalities typically used to assess CP. Pancreatic duct features are assessed with magnetic resonance cholangiopancreatography (MRCP) and endoscopic retrograde cholangiopancreatography (ERCP). However, ERCP is a rather invasive diagnostic modality for CP, and can result in adverse events such as post-ERCP pancreatitis. Computed tomography (CT) is often the most appropriate initial imaging modality for patients with suspected CP, and has high diagnostic specificity. However, CT findings typically only appear in advanced stages of CP, and it is difficult to detect early CP. Endoscopic ultrasonography (EUS) provides superior spatial resolution compared with other imaging modalities such as CT and magnetic resonance imaging (MRI), and is considered the most reliable and efficient diagnostic modality for pancreatic diseases. The EUS-based Rosemont classification plays an important role in diagnosing CP in clinical practice. Evaluation of tissue stiffness can be another option to assess the diagnosis and progression of CP, and MRI and EUS can be used to assess CP not only with imaging, but also with elasticity measurement. MR and EUS elastography are expected to provide new alternative diagnostic tools for assessment of fibrosis in CP, which is difficult to evaluate pathologically.
Tissue Inhibitor of Metalloproteinase-3 Ameliorates Diabetes-Induced Retinal Inflammation
Authors: Abu El-Asrar Ahmed M. , Ahmad Ajmal , Nawaz Mohd Imtiaz , Siddiquei Mohammad Mairaj , De Zutter Alexandra , Vanbrabant Lotte , Gikandi Priscilla W. , Opdenakker Ghislain , Struyf Sofie
Published: January 2022

Purpose: Endogenous tissue inhibitor of matrix metalloproteinase-3 (TIMP-3) has powerful regulatory effects on inflammation and angiogenesis. In this study, we investigated the role of TIMP-3 in regulating inflammation in the diabetic retina.

Methods: Vitreous samples from patients with proliferative diabetic retinopathy (PDR) and non-diabetic patients were subjected to Western blot analysis. Streptozotocin-treated rats were used as a preclinical diabetic retinopathy (DR) model. Blood-retinal barrier (BRB) breakdown was assessed with fluorescein isothiocyanate (FITC)-conjugated dextran. Rat retinas, human retinal microvascular endothelial cells (HRMECs) and human retinal Müller glial cells were studied by Western blot analysis and ELISA. Adherence of human monocytes to HRMECs was assessed and in vitro angiogenesis assays were performed.

Results: Tissue inhibitor of matrix metalloproteinase-3 in vitreous samples was largely glycosylated. Intravitreal injection of TIMP-3 attenuated diabetes-induced BRB breakdown. This effect was associated with downregulation of diabetes-induced upregulation of the p65 subunit of NF-κB, intercellular adhesion molecule-1 (ICAM-1), and vascular endothelial growth factor (VEGF), whereas phospho-ERK1/2 levels were not altered. In Müller cell cultures, TIMP-3 significantly attenuated VEGF upregulation induced by high-glucose (HG), the hypoxia mimetic agent cobalt chloride (CoCl2) and TNF-α and attenuated MCP-1 upregulation induced by CoCl2 and TNF-α, but not by HG. TIMP-3 attenuated HG-induced upregulation of phospho-ERK1/2, caspase-3 and the mature form of ADAM17, but not the levels of the p65 subunit of NF-κB and the proform of ADAM17 in Müller cells. TIMP-3 significantly downregulated TNF-α-induced upregulation of ICAM-1 and VCAM-1 in HRMECs. Accordingly, TIMP-3 significantly decreased spontaneous and TNF-α- and VEGF-induced adherence of monocytes to HRMECs. Finally, TIMP-3 significantly attenuated VEGF-induced migration, chemotaxis and proliferation of HRMECs.

Conclusion:In vitro and in vivo data point to anti-inflammatory and anti-angiogenic effects of TIMP-3 and support further studies for its applications in the treatment of DR.
Root Morphogenesis of Arabidopsis thaliana Tuned by Plant Growth-Promoting Streptomyces Isolated From Root-Associated Soil of Artemisia annua
Authors: Fu Wenbo , Pan Yanshuo , Shi Yuhua , Chen Jieyin , Gong Daozhi , Li Yuzhong , Hao Guangfei , Han Dongfei
Published: January 2022

In this study, the capacity to tune root morphogenesis by a plant growth-promoting rhizobacterium, Streptomyces lincolnensis L4, was investigated from various aspects including microbial physiology, root development, and root endophytic microbial community. Strain L4 was isolated from the root-associated soil of 7-year plantation of Artemisia annua. Aiming at revealing the promotion mechanism of Streptomyces on root growth and development, this study first evaluated the growth promotion characters of S. lincolnensis L4, followed by investigation in the effect of L4 inoculation on root morphology, endophytic microbiota of root system, and expression of genes involved in root development in Arabidopsis thaliana. Streptomyces lincolnensis L4 is able to hydrolyze organic and inorganic phosphorus, fix nitrogen, and produce IAA, ACC deaminase, and siderophore, which shaped specific structure of endophytic bacterial community with dominant Streptomyces in roots and promoted the development of roots. From the observation of root development characteristics, root length, root diameter, and the number of root hairs were increased by inoculation of strain L4, which were verified by the differential expression of root development-related genes in A. thaliana. Genomic traits of S. lincolnensis L4 which further revealed its capacity for plant growth promotion in which genes involved in phosphorus solubilization, ACC deamination, iron transportation, and IAA production were identified. This root growth-promoting strain has the potential to develop green method for regulating plant development. These findings provide us ecological knowledge of microenvironment around root system and a new approach for regulating root development.
The Cell Differentiation of Idioblast Myrosin Cells: Similarities With Vascular and Guard Cells
Authors: Shirakawa Makoto , Tanida Mai , Ito Toshiro
Published: January 2022

Idioblasts are defined by abnormal shapes, sizes, and contents that are different from neighboring cells. Myrosin cells are Brassicales-specific idioblasts and accumulate a large amount of thioglucoside glucohydrolases (TGGs, also known as myrosinases) in their vacuoles. Myrosinases convert their substrates, glucosinolates, into toxic compounds when herbivories and pests attack plants. In this review, we highlight the similarities and differences between myrosin cells and vascular cells/guard cells (GCs) because myrosin cells are distributed along vascular cells, especially the phloem parenchyma, and myrosin cells share the master transcription factor FAMA with GCs for their cell differentiation. In addition, we analyzed the overlap of cell type-specific genes between myrosin cells and GCs by using published single-cell transcriptomics (scRNA-seq) data, suggesting significant similarities in the gene expression patterns of these two specialized cells.
Lessons From Rojava for the Paradigm of Social Ecology
Authors: Hammy Cihad , Miley Thomas Jeffrey
Published: January 2022

This essay addresses two related questions raised by the editors of the research topic for “Beyond the Frontiers of Political Science: Is Good Governance Possible in Cataclysmic Times?” In particular, it explores: 1) how we can identify new tools and perspectives from which to address the multiple and mutually reinforcing problems accumulating around climate change; and 2) what institutional alternatives to the nation-state need to be created and empowered to tackle such complex problems. It does so through an in-depth treatment of the paradigm of “social ecology” and the associated political project of “democratic confederalism.” It begins with an overview of the argument, first advanced by Murray Bookchin and subsequently adopted and adapted by the imprisoned Kurdish leader Abdullah Öcalan, that building an ecological society requires an assault on hierarchy in all its forms, and the construction of alternative, direct-democratic institutions capable of transcending the system of the capitalist nation-state. It sketches the institutional architecture of popular assemblies central to this project, both emphasizing their potential to contest capitalist social-property relations and hierarchies intrinsic to the nation-state and pointing out some sources of resilience of the existing system. It hones in on the experience of the revolutionary forces in control of the Autonomous Administration of North East Syria (AANES), who have been directly inspired by Öcalan’s ideas. It highlights both the AANES’s achievements as well as the significant obstacles it has encountered in the attempt to bring into being a radically-egalitarian, ecological society. It concludes by drawing lessons from these difficulties.
Improving the Sustainable Usage Intention of Mobile Payments: Extended Unified Theory of Acceptance and Use of Technology Model Combined With the Information System Success Model and Initial Trust Model
Authors: Lin Xin , Suanpong Kwanrat , Ruangkanjanases Athapol , Lim Yong-Taek , Chen Shih-Chih
Published: January 2022

Under the background of global cross-border mobile commerce (m-commerce) integration, the importance of cross-border payment research is becoming increasingly prominent and urgent. The important value of this study is to empirically research the influence power of key elements in using two different mobile payment (m-payment) platforms in Korea. The extended unified theory of acceptance and use of technology (UTAUT2) has been widely applied in various studies because of its strong interpretive power. In Korea, there are a few empirical studies on Chinese users. Based on a survey of 908 Chinese participants (486 WeChat Pay’s Chinese users and 465 Kakao Pay’s Korean users) in Korea, this study is one application extending UTAUT2 by incorporating multi-group and multi-model constructs: UTAUT2, information system success (ISS) model, and an initial trust model (ITM), considering a multi-group analysis with some mediating variables (payment difference). By comparing the two different payment platforms’ characters, this manuscript provides a set of targeted measures to ensure Chinese WeChat Payment platform decision-makers create effective long-term strategic policies for cross-border m-payments in Korea, and eventually, benefit cross-border m-commerce and economic cooperation in Southeast Asia.
Feel to Heal: Negative Emotion Differentiation Promotes Medication Adherence in Multiple Sclerosis
Authors: Seah T. H. Stanley , Almahmoud Shaima , Coifman Karin G.
Published: January 2022

Multiple Sclerosis (MS) is a debilitating chronic autoimmune disease of the central nervous system that results in lower quality of life. Medication adherence is important for reducing relapse, disease progression, and MS-related symptoms, particularly during the early stages of MS. However, adherence may be impacted by negative emotional states. Therefore, it is important to identify protective factors. Past research suggests that the ability to discriminate between negative emotional states, also known as negative emotion differentiation (NED), may be protective against enactment of maladaptive risk-related behaviors. However, less is known as to how NED may promote adaptive health behaviors such as medication adherence. Utilizing weekly diaries, we investigated whether NED moderates the association between negative affect and medication adherence rates across 58 weeks among patients (n = 27) newly diagnosed with MS (following McDonald criteria). Results revealed that NED significantly moderated the relationship between negative affect and medication adherence. Specifically, greater negative affect was associated with lower adherence only for individuals reporting low NED. However, this link disappeared for those reporting moderate to high NED. Building upon past research, our findings suggest that NED may promote adaptive health behaviors and have important clinical implications for the treatment and management of chronic illness.
Learning Social Media Content Optimization: How Can SMEs Draw the Users' Attention on Official WeChat Accounts?
Authors: Zeng Xueyun , Xu Xuening , Wu Yenchun Jim
Published: January 2022

Application of artificial intelligence is accelerating the digital transformation of enterprises, and digital content optimization is crucial to take the users' attention in social media usage. The purpose of this work is to demonstrate how social media content reaches and impresses more users. Using a sample of 345 articles released by Chinese small and medium-sized enterprises (SMEs) on their official WeChat accounts, we employ the self-determination theory to analyze the effects of content optimization strategies on social media visibility. It is found that articles with enterprise-related information optimized for content related to users' psychological needs (heart-based content optimization, mind-based content optimization, and knowledge-based content optimization) achieved higher visibility than that of sheer enterprise-related information, whereas the enterprise-related information embedded with material incentive (benefits-based content optimization) brings lower visibility. The results confirm the positive effect of psychological needs on the diffusion of enterprise-related information, and provide guidance for SMEs to apply artificial intelligence technology to social media practice.
The Influence of Technical and Contextual Variables of the Last Stroke on Point Outcome in Men’s and Women’s Singles Badminton
Authors: Sheng Yi , Yi Qing , Gómez-Ruano Miguel-Ángel , Chen Peijie
Published: January 2022

The purpose of this study was to identify the effects of the technical and context-related variables of last strokes in rallies on the point outcomes of both men’s and women’s players in elite singles badminton matches. A total of 100 matches during the 2018 and 2019 seasons were analyzed, and the data of 4,080 men’s rallies and 4,339 women’s rallies were collected. The technical variables including strokes per rally, forehand strokes, overhead strokes, and defensive action, and the context-related variables including game status, result against serve, importance of rally, and importance of set, were modeled with Probit regression modeling as the predictor variables. The binary variables of “winner or not” and “error or not” were considered the response variables. The results showed that defensive actions had the greatest impacts on the winners and errors of both the men’s and women’s singles players, and the forehand and overhead strokes were negatively associated with the winners and errors of the women’s singles players and the winners of the men’s singles players. No significant effects were found for the strokes per rally on the winners and errors of the men’s singles players, while significant effects were found for the women’s singles players. The context-related variables appeared to have positive effects on the winners and negative effects on the errors of both sexes. These findings can provide important insights for coaches and players to evaluate their performances of last strokes in rallies and to improve training interventions and match tactics and strategies.
Emotional Intelligence, Emotional Regulation Strategies, and Subjective Well-Being Among University Teachers: A Moderated Mediation Analysis
Authors: Sha Jingrong , Tang Tianqi , Shu Hong , He Kejian , Shen Sha
Published: January 2022

This study aimed to explore the mediating role of emotional regulation strategies in the relationship between emotional intelligence (EI) and subjective well-being (SWB) among Chinese university teachers, and evaluate whether effort-reward imbalance moderated the mediating effect of emotional regulation strategies. A total of 308 Chinese university teachers were recruited for this study. The results showed that emotional regulation strategies played a partial mediating role in the relationship between EI and SWB. Moreover, an effort-reward imbalance moderated the relationship between emotional regulation strategies and SWB. For individuals with more balanced perceptions, EI had a significant effect on SWB via cognitive reappraisal, while for individuals with more imbalanced perceptions, EI did not have a significant effect on SWB via cognitive reappraisal. These findings provide a better understanding of the effects of EI and emotional regulation strategies on SWB, which could provide interventions for promoting SWB among teachers.
Post-traumatic Stress Disorder Symptoms and Quality of Life of COVID-19 Survivors at 6-Month Follow-Up: A Cross-Sectional Observational Study
Authors: Huang Liqun , Xu Xiaohua , Zhang Lingjie , Zheng Danwen , Liu Yuntao , Feng Bing , Hu Jiajun , Lin Qiaoli , Xi Xiaotu , Wang Qian , Lin Meixuan , Zhou Xin , He Zehui , Weng Heng , Deng Qiuying , Ding Banghan , Guo Jianwen , Zhang Zhongde
Published: January 2022

Background: Post-traumatic stress disorder (PTSD) is the most common psychiatric sequelae among novel coronavirus disease (COVID-19) patients. The aim of this study was to determine the prevalence of PTSD symptoms, PTSD-related factors, and its relationship with quality of life at long-term follow-up in hospitalized COVID-19 survivors.

Methods: A cross-sectional study was undertaken to evaluate the health consequences of hospitalized COVID-19 survivors. All participants were interviewed face-to-face through a series of questionnaires: a researcher-developed symptom questionnaire, the Post-traumatic Stress Disorder Checklist–Civilian Version, the Generalized Anxiety Disorder 7-item, and the 36-item Short Form.

Results: A total of 574 participants were enrolled with an average age of 57 years. The median follow-up time post-discharge was 193.9 days (SD = 15.32). Among the participants, 77.9% of survivors presented with at least one symptom, where fatigue or muscle weakness (47.9%) was reported the most frequently, followed by chest distress (29.4%) and sleep difficulty (29.4%). The prevalence of PTSD was 11.15% [95% confidence interval (CI): 8.56, 13.73] with a cut-off score of 44. Factors such as respiratory symptoms [odds ratio (OR): 3.53; 95% CI: 1.68–7.42], anxiety (OR: 14.64; 95% CI: 7.09–30.21), and sleep difficulty (OR: 2.17; 95% CI: 1.14–4.16) were positively related to PTSD. Those COVID-19 survivors with potential PTSD had significantly lower quality of life than those without (P < 0.05).

Conclusion: Our study illustrated that a significant number of COVID-19 survivors were suffering from physical or mental distress to varying degrees at 6 months post-discharge. People with PTSD were more likely to experience persistent respiratory symptoms and sleep difficulty, as well as anxiety and a decreased quality of life. Such survivors require greater attention to their mental health, particularly the PTSD symptoms at the early phase, which may play an important role in the recovery of both the physical and psychological health of COVID-19 survivors.
Exploring the Neuropsychiatric Sequalae of Perceived COVID-19 Exposure in College Students: A Pilot Digital Phenotyping Study
Authors: Patel Suraj K. , Torous John
Published: January 2022

The urgency to understand the long-term neuropsychiatric sequala of COVID-19, a part of the Post-Acute COVID-19 Syndrome (PACS), is expanding as millions of infected individuals experience new unexplained symptoms related to mood, anxiety, insomnia, headache, pain, and more. Much research on PACS involves cross sectional surveys which limits ability to understand the dynamic trajectory of this emerging phenomenon. In this secondary analysis, we analyzed data from a 4-week observational digital phenotyping study using the mindLAMP app for 695 college students with elevated stress who specified if they were exposed to COVID-19. Students also completed a biweekly survey of clinical assessments to obtain active data. Additionally, passive data streams like GPS, accelerometer, and screen state were extracted from phone sensors and through features the group built. Three hundred and eighty-second number participants successfully specified their COVID-19 exposure and completed the biweekly survey. From active smartphone data, we found significantly higher scores for the Prodromal Questionnaire (PQ) and the Pittsburgh Sleep Quality Index (PSQI) for students reporting exposure to COVID-19 compared to those who were not (ps < 0.05). Additionally, we found significantly decreased sleep duration as captured from the smartphone via passive data for the COVID-19 exposed group (p < 0.05). No significant differences were detected for other surveys or passive sensors. Smartphones can capture both self-reported symptoms and behavioral changes related to PACS. Our results around changes in sleep highlight how digital phenotyping methods can be used in a scalable and accessible manner toward better capturing the evolving phenomena of PACS. The present study further provides a foundation for future research to implement improving digital phenotyping methods.
Adjunctive Magnetic Seizure Therapy for Schizophrenia: A Systematic Review
Authors: Zhang Xin-Yang , Chen Huo-Di , Liang Wan-Nian , Yang Xin-Hu , Cai Dong-Bin , Huang Xiong , Huang Xing-Bing , Liu Cheng-Yi , Zheng Wei
Published: January 2022

Objective: The efficacy and safety of adjunctive magnetic seizure therapy (MST) for patients with schizophrenia are unclear. This systematic review was conducted to examine the efficacy and safety of adjunctive MST for schizophrenia.

Methods: Chinese (WanFang and Chinese Journal Net) and English (PubMed, EMBASE, PsycINFO, and the Cochrane Library) databases were systematically searched.

Results: Two open-label self-controlled studies (n = 16) were included and analyzed in this review. In these studies, the Positive and Negative Syndrome Scale (PANSS) total scores and Brief Psychiatric Rating Scale (BPRS) total scores significantly decreased from baseline to post-MST (all Ps < 0.05), without serious adverse neurocognitive effects. Mixed findings on the neurocognitive effects of adjunctive MST for schizophrenia were reported in the two studies. A discontinuation rate of treatment of up to 50% (4/8) was reported in both studies. The rate of adverse drug reactions (ADRs) was evaluated in only one study, where the most common ADRs were found to be dizziness (25%, 2/8) and subjective memory loss (12.5%, 1/8).

Conclusion: There is inconsistent evidence for MST-related adverse neurocognitive effects and preliminary evidence for the alleviation of psychotic symptoms in schizophrenia.
The Importance of Biobehavioral Research to Examine the Physiological Effects of Racial and Ethnic Discrimination in the Latinx Population
Authors: Martínez Airín D. , Mercado Evelyn , Barbieri Marielena , Kim Su Yeong , Granger Douglas A.
Published: January 2022

A growing body of research is documenting how racial and ethnic populations embody social inequalities throughout the life course. Some scholars recommend the integration of biospecimens representing the hypothalamic-pituitary-adrenal axis, neurological and endocrinological processes, and inflammation to capture the embodiment of inequality. However, in comparison to other racial and ethnic groups, there has been little research examining how Hispanic/Latinx persons embody racial and ethnic discrimination, much less resulting from institutional and structural racism. We provide a rationale for expanding biobehavioral research examining the physiological consequences of racism among Latinx persons. We identify gaps and make recommendations for a future research agenda in which biobehavioral research can expand knowledge about chronic disease inequities among Latinx populations and inform behavioral and institutional interventions. We end by cautioning readers to approach the recommendations in this article as a call to expand the embodiment of racism research to include the diverse Latinx population as the United States addresses racial inequity.
Cost-Effectiveness Analysis of Tyrosine Kinase Inhibitors in Gastrointestinal Stromal Tumor: A Systematic Review
Authors: Feng Mingyang , Yang Yang , Liao Weiting , Li Qiu
Published: January 2022

Background: The introduction of tyrosine kinase inhibitor (TKI) therapy has dramatically improved the clinical effectiveness of patients with locally advanced and/or metastatic gastrointestinal stromal tumors (GIST), and this systematic review was conducted aiming at the cost-effectiveness analysis of TKIs in GIST.

Methods: A thorough literature search of online databases was performed, using appropriate terms such as “gastrointestinal stromal tumor or GIST,” “cost-effectiveness,” and “economic evaluation.” Data extraction was conducted independently by two authors, and completeness of reporting and quality of the evaluation were assessed. The systematic review was conducted following the PRISMA statement.

Results: Published between 2005 and 2020, 15 articles were incorporated into the systematic review. For advanced GIST, imatinib followed by sunitinib was considered cost-effective, and regorafenib was cost-effective compared with imatinib re-challenge therapy in the third-line treatment. For resectable GIST, 3-year adjuvant imatinib therapy represented a cost-effective treatment option. The precision medicine-assisted imatinib treatment was cost-effective compared with empirical treatment.

Conclusion: Although identified studies varied in predicted costs and quality-adjusted life years, there was general agreement in study conclusions. More cost-effectiveness analysis should be conducted regarding more TKIs that have been approved for the treatment of GIST.

Systematic Review Registration:https://www.crd.york.ac.uk/, PROSPERO: CRD42021225253.
The Superficial Anastomosing Veins of the Human Brain Cortex: A Microneurosurgical Anatomical Study
Authors: Tomasi S. Ottavio , Umana Giuseppe Emmanuele , Scalia Gianluca , Raudino Giuseppe , Graziano Francesca , Palmisciano Paolo , Priola Stefano M. , Cappai Pier Francesco , Capone Crescenzo , Lawrence Peter M. , Erös Christian A. , Martin Klaus D. , Chaurasia Bipin , Maugeri Rosario , Iacopino Gerardo , Da Ros Valerio , Lawton Michael T. , Griessenauer Christoph J. , Winkler Peter A.
Published: January 2022

Introduction: In this microneurosurgical and anatomical study, we characterized the superficial anastomosing veins of the human brain cortex in human specimens.

Material and Methods: We used 21 brain preparations fixed in formalin (5%) that showed no pathological changes and came from the autopsy sections. The superficial veins were dissected out of the arachnoid with the aid of a surgical microscope.

Results: We dissected nine female and 12 male brain specimens, with an average age of 71 ± 11 years (range 51–88 years). We classified the superficial veins in five types: (I) the vein of Trolard as the dominat vein; (II) the vein of Labbé as the dominant vein; (III) a dominant sylvian vein group, and the veins of Trolard and Labbé nonexistent or only rudimentary present without contact to the Sylvian vein group; (IV) very weak sylvian veins with the veins of Trolard and Labbé codominant; and V) direct connection of Trolard and Labbé bypassing the Sylvian vein group. The vein of Trolard was dominant (Type I) in 21.4% and the vein of Labbé (Type II) in 16.7%. A dominant sylvian vein group (Type III) was found in 42.9%. Type IV and Type V were found in 14.3 and 4.7% respectively.

Conclusion: No systematic description or numerical distribution of the superior anastomotic vein (V. Trolard) and inferior anastomotic vein (V. Labbé) has been found in the existing literature. This study aimed to fill this gap in current literature and provide data to neurosurgeons for the practical planning of surgical approaches.
First Report of Fecal Microflora of Wild Bar-Headed Goose in Tibet Plateau
Authors: Dong Shixiong , Xu Shijun , Zhang Jian , Hussain Riaz , Lu Hong , Ye Yourong , Mehmood Khalid , Zhang Hui , Shang Peng
Published: January 2022

The bar-headed goose (Anser indicus) has two black spots on its head. It is considered an important bird in China. It breeds in plateau lakes, especially saltwater lakes, and swamp areas. However, the intestinal flora of wild bar-headed geese in the Tibet Autonomous Region is currently not known. In this study, 16S rDNA sequencing was performed on the intestinal microbes of wild bar-headed geese. A total of 513,505 reads of raw data were obtained, and the results analyzed the average number of 128,376 ± 2,392 reads per sample. The microbiota of all samples consists of 10 main bacterial phyla, including Firmicutes, Proteobacteria, Bacteroidetes, Actinobacteria, Cyanobacteria, Patescibacteria, Deferribacteres, Planctomy-cetes, Fusobacteria, and Tenericutes. The results indicated that Firmicutes (67.34%) was the predominant phylum, followed by Proteobacteria (29.03%) and Cyanobacteria (1.97%). In our research, we identified the intestinal flora of the wild bar-headed goose, which provides valuable information for further research on the gene function of the bar-headed goose and the intestinal flora of wild animals. These findings are also useful and valuable for genetic and high-altitude research in the Tibet Autonomous Region.
The Influence of Residue Mixing on the Decomposition of Pepper Root Residues
Authors: Zhang Xianhong , Wang Zhilin , Wu Fengzhi , Zhou Xingang
Published: January 2022

(1) Background: Residue degradation plays a very important role in terrestrial ecosystems and residue mixing is the main factor affecting the degradation rates. However, in the agricultural systems, the effect of residue mixing on the degradation of pepper residues and the microbial community in pepper root residues is not clear. (2) Methods: In this study, we added different residues into soil by using double-layered nylon litterbags in culture bottles. The treatments including pepper root (P: Capsicum annuum L.), soybean [S: Glycine max (L.) Merr.] and maize (M: Zea mays L.) residue, as well as mixtures of soybean + pepper (SP), maize + pepper (MP), maize + soybean + pepper (MSP) mixtures. Litterbags were harvested after 7, 14, 28, and 56 days, respectively. Mass loss and nitrogen and phosphorus contents in pepper residue were quantified and bacterial and fungal community levels in pepper residues were analyzed using quantitative PCR and high throughput amplicon sequencing; (3) Results: The study showed that the mass loss and fungal community abundance of pepper root residue in mixtures were higher than P, except day 7. The phosphorus contents in MSP-P and MP-P were significantly lower than that for P at day 28 and day 56. Illumina MiSeq sequencing showed that the presence of maize residue significantly altered the microbial community composition of pepper root pepper. Day 56. (4) Conclusions: Our results suggest that residue mixing changed the microbial community abundance in pepper residue and promoted the degradation of pepper residues compared to pepper residue decomposition alone, especially for mixtures with soybean.
Relationship between Precipitation Characteristics at Different Scales and Drought/Flood during the Past 40 Years in Longchuan River, Southwestern China
Authors: Liu Yuan , Yan Dongchun , Wen Anbang , Shi Zhonglin , Chen Taili , Chen Ruiyin
Published: January 2022

In this study, the temporal and spatial patterns of rainfall in the Longchuan River basin from 1977 to 2017 were analyzed, to assess the feature of precipitation. Based on the daily precipitation time series, the Lorenz curve, precipitation concentration index (PCI), precipitation concentration degree (PCD), and the precipitation concentration period (PCP) were used to evaluate the precipitation distribution characteristics. The PCI, PCD and PCP in five categories, defined by the fixed thresholds, were proposed to investigate the concentrations, and the average values indicated the higher concentrations in the higher intensities. The indices showed strong irregularity of daily and monthly precipitation distributions in this basin. The decrease in the PCD revealed an increase in the proportion of precipitation in the dry season. The rainy days of slight precipitation in the upper and lower basins with significant downward trends (−13.13 d/10 a, −7.78 d/10 a) led to longer dry spells and an increase in the risk of drought, even severe in the lower area. In the upper basin, the increase in rainfall erosivity was supported by the upward trend in the PCIw of heavy precipitation and the simple daily intensity index (SDII) of extreme precipitation. Moreover, the PCP of light precipitation, moderate precipitation, and heavy precipitation concentrated earlier at the end of July. The results of this study can provide beneficial reference information to water resource planning, reservoir operation, and agricultural production in the basin.
The Impact of Agricultural Use of Retisols on the Molecular Structure of Humic Substances
Authors: Lodygin Evgeny , Abakumov Evgeny
Published: January 2022

Agricultural soil use does not only affect the amount of soil organic matter, but also the molecular composition of humic (HAs) and fulvic acids (FAs). Changed hydrothermal conditions and composition of the incoming plant residues are reflected in the rate of humification and its products. The objective of this study was to compare the molecular composition of HAs and FAs isolated from Eutric Albic Stagnic Histic Retisol (Loamic), two Eutric Albic Retisols (Loamic)—mature and arable. Plots of mature Retisols are located at a middle taiga (Komi Republic, Russia) in a bilberry-green-moss birch-spruce forest. The plot of Retisols arable is located in the fields of the Syktyvkar state farm, which is 3.3 km northeast of mature Retisol plots. The development period is about 40 years, it is sowed with a pea-oat mixture. The results obtained indicate that soil reclamation essentially increases the proportion of aromatic components and decreases the content of carboxyl and ester groups in the humic substance (HS) structure. An increased extent of hydromorphism of Retisols leads to the enrichment of HS with aliphatic fragments.
Over-Optimistic Projected Future Wheat Yield Potential in the North China Plain: The Role of Future Climate Extremes
Authors: Yang Rui , Dai Panhong , Wang Bin , Jin Tao , Liu Ke , Fahad Shah , Harrison Matthew Tom , Man Jianguo , Shang Jiandong , Meinke Holger , Liu Deli , Wang Xiaoyan , Zhang Yunbo , Zhou Meixue , Tian Yingbing , Yan Haoliang
Published: January 2022

Global warming and altered precipitation patterns pose a serious threat to crop production in the North China Plain (NCP). Quantifying the frequency of adverse climate events (e.g., frost, heat and drought) under future climates and assessing how those climatic extreme events would affect yield are important to effectively inform and make science-based adaptation options for agriculture in a changing climate. In this study, we evaluated the effects of heat and frost stress during sensitive phenological stages at four representative sites in the NCP using the APSIM-wheat model. climate data included historical and future climates, the latter being informed by projections from 22 Global Climate Models (GCMs) in the Coupled Model Inter-comparison Project phase 6 (CMIP6) for the period 2031–2060 (2050s). Our results show that current projections of future wheat yield potential in the North China Plain may be overestimated; after more accurately accounting for the effects of frost and heat stress in the model, yield projections for 2031-60 decreased from 31% to 9%. Clustering of common drought-stress seasonal patterns into key groups revealed that moderate drought stress environments are likely to be alleviated in the future, although the frequency of severe drought-stress environments would remain similar (25%) to that occurring under the current climate. We highlight the importance of mechanistically accounting for temperature stress on crop physiology, enabling more robust projections of crop yields under future the burgeoning climate crisis.
Absorption and Distribution of Calcium (45Ca) Applied to the Surface of Orange (Citrus sinensis) Fruits at Different Developmental Stages
Authors: Bonomelli Claudia , Fernández Victoria , Capurro Franco , Palma Carola , Videla Ximena , Rojas-Silva Ximena , Nario Adriana , Mártiz Johanna
Published: January 2022

In this study, the rate of absorption and transport of calcium (Ca) in orange fruits (Citrus sinensis cv. Fukumoto) after surface treatment with 45Ca was evaluated by supplying treatments at different dates between fruit set and mid-phase II of growth (i.e., 30, 44, 66 and 99 days after full bloom, DAFB). 45Ca absorption was always detected, but 45Ca application at the fruit set was associated with the highest rates of Ca transport into the pulp (39%) compared to the other treatments (17–19%). Scanning electron microscopy SEM) images of the fruit surface showed the occurrence of stomata along with the entire rind at all the developmental stages evaluated. However, from the beginning of stage I, stomata began to collapse and develop plugs, and this became frequent as the fruit age increased. From 44 DAFB, oil gland density increased, and Ca oxalates (CaOx) were found in the fruit flavedo and albedo. Fruit Ca (not labeled) concentration increased from fruit set (30 DAFB) to 99 DAFB, although oil gland formation and rind growth and differentiation likely hindered Ca transport to internal fruit tissues (pulp). The total Ca concentration in the pedicel was always higher than that in the fruit, with no differences between the first three treatments. The information obtained in this study may be essential for improving Ca fertilizer efficacy in citrus by spray applications.
Analysis of the Acceptance of Sustainable Practices in Water Management for the Intensive Agriculture of the Costa de Hermosillo (Mexico)
Authors: Ochoa-Noriega Claudia , Velasco-Muñoz Juan F. , Aznar-Sánchez José A. , López-Felices Belén
Published: January 2022

Mexico, as many countries, relies on its aquifers to provide at least 60% of all irrigation water to produce crops every year. Often, the water withdrawal goes beyond what the aquifer can be replenished by the little rainfall. Mexico is a country that has experienced a successful process of regional development based on the adoption of intensive agricultural systems. However, this development has occurred in an unplanned way and displays shortcomings in terms of sustainability, particularly in the management of water resources. This study analysed the case of Costa de Hermosillo, which is one of the Mexican regions in which this model of intensive agriculture has been developed and where there is a high level of overexploitation of its groundwater resources. Based on the application of a qualitative methodology involving different stakeholders (farmers, policymakers, and researchers), the main barriers and facilitators for achieving sustainability in water resources management have been identified. A series of consensus-based measures were contemplated, which may lead to the adoption of sustainable practices in water management. Useful lessons can be drawn from this analysis and be applied to other agricultural areas where ground and surface water resources are overexploited, alternative water sources are overlooked, and where stakeholders have conflicting interests in water management.
Impact of Sowing Time on Chickpea (Cicer arietinum L.) Biomass Accumulation and Yield
Authors: Richards Mark F. , Maphosa Lancelot , Preston Aaron L.
Published: January 2022

Chickpea growth, development and grain yield are affected by a range of climatic and environmental factors. Experiments were conducted across four sowing dates from mid-April to the end of May, over two years at Trangie in central western New South Wales (NSW), and Leeton, Wagga Wagga and Yanco (one year) in southern NSW, to examine the influence of sowing time on biomass accumulation, grain yield and plant yield components. Climatic and experimental location data were recorded during the growing seasons. Early sowing (mid-April) resulted in taller plants, higher bottom and top pod heights, fewer pods, more unfilled pods and greater biomass accumulation, but low harvest index due to reduced grain yield compared with late sowing (end of May). Grain number was positively correlated with grain yield and was the main yield component accounting for most of the variation in yield. There was largely a positive correlation between biomass and yield, especially with delayed sowing except for Leeton experiments. This study concludes that sowing around the end of April in central western NSW and mid-May in southern NSW is conducive to higher grain yield as it minimises exposure to abiotic stresses at critical growth periods and allows efficient conversion of biomass to grain yield.