bluuebunny/crossref_metadata_2025 huggingface dataset:
Simulation Of The K-Means Clustering Algorithm With The Elbow Method in Making Clusters Of Provincial Poverty Levels in Indonesia
Authors: Riyono Joko , Pujiastuti Christina Eni
Published: April 2024

One way to ensure that government programs and assistance for each province are right on target is to create a model of grouping or clustering provinces in Indonesia based on poverty levels. Algorithm K Means is one of the clustering methods in Data Mining to divide n observations into k groups so that each observation is in the group with the closest mean. In this study, provincial poverty level clustering in Indonesia will be made based on three poverty level indicators, namely the Percentage of Poor Population (P0), Poverty Depth (P1), and Poverty Severity (P2) with the K-Means Algorithm using the Elbow Method assisted by the Python Program. The results obtained are 5 optimal clusters of provincial poverty rates in Indonesia.
Developing A Secure Cryptosystem with Rainbow Vertex Antimagic Coloring of Cycle Graph
Authors: Marsidi Marsidi
Published: April 2024

An edge labeling of graph G is a function g from the edge set of graph G to the first natural numbers up to the number of the edge set. Graph G admits a rainbow vertex antimagic coloring if, for any two vertices, there is a path with different colors of all internal vertices. The vertex color of graph G is assigned by vertex weight. The vertex weight of graph G is obtained by summing all edge labels that incident with that vertex. The rainbow vertex antimagic connection number of graph G, denoted by rvac(G) is the smallest number of different colors induced by rainbow vertex antimagic coloring. In this research, we determine the upper bound of the rainbow vertex antimagic connection number (rvac)  on a cycle graph (Cn) and create a secured cryptosystem using a modified Affine Cipher based on rainbow vertex antimagic coloring.
Effect of streptococcal arginine deiminase on the function of CD4+ and CD8+T lymphocytes
Authors: Starikova E. A. , Mammedova J. T. , Ozhiganova A. , Lebedeva A. M. , Leveshko T. A. , Burova L. A. , Kudryavtsev I. V.
Published: April 2024

Arginine metabolism plays an important role in regulating the functions of immune cells in mammals. Pathogenic microbes use the mechanism of arginine depletion to suppress the immune response during infection. Arginine deiminase is a microbial arginine-hydrolyzing enzyme important for survival at low pH in the focus of infection, or in phagolysosomes, as well as under low-glucose conditions. The effect of bacterial arginine deiminase on the functions of adaptive immune cells remains poorly understood. The aim of our study was to evaluate the effect of streptococcal arginine deiminase on the proliferation and autophagy of CD4+ and CD8+ human peripheral blood T lymphocytes.

The enzyme effects were studied with supernates of ultrasonic lysates from parental Streptococcus pyogenes M49-16, and its isogenic mutant with inactivated arcA gene (Streptococcus pyogenes M49-16delarcA). The study was performed with blood samples of healthy donors. The fraction of mononuclear leukocytes was isolated by centrifugation in a Ficoll density gradient. To evaluate proliferation levels, a method based on the staining of intracellular proteins with vital fluorescent dye carboxyfluorescein succinimidyl ester (CFSE) was used. The level of autophagy was studied using the fluorescent Lysotracker Green DND-26 dye. To analyze the proliferation and autophagy of T helper cells (CD3+CD4+) and cytotoxic T lymphocytes (CD3+CD4-), the obtained cell suspensions were stained with antibodies against CD4, CD45RA, and CD3. The proportion of necrotic cells was determined by staining with a fluorescent DNA-binding DAPI dye. The normality of the distribution was assessed by Shapiro–Wilk test. The data were analyzed using Kruskal–Wallis criterion, followed by Mann–Whitney criterion for pairwise comparisons and expressed as median and interquartile ranges (Q0.25-Q0.75).

When comparing the effects of supernatants from the parental and mutant streptococcal strains, which differed in expression of arginine deiminase gene, we have shown that the bacterial enzyme had no effect on the functions of inactive lymphocytes. However, streptococcal arginine deiminase completely suppressed proliferation of CD4+ and CD8+T lymphocytes stimulated with anti-CD2/CD3/CD28 antibodies. These effects were accompanied by a decrease in the autophagy levels. At the same time, arginine deiminase did not exert cytotoxic effects upon lymphocytes. L-arginine applied at the doses exceeding physiological levels caused restoration of the cellular functions. There were no differences between the studied parameters of CD4+ and CD8+T lymphocyte subsets.

The obtained data show that the antiproliferative effect of arginine demimnase may be associated with ability of the enzyme to inhibit autophagy and confirm an opportunity of the bacterial enzyme to suppress host adaptive immune responses.
Experience of using immunomodulatory therapy in the complex treatment of mild community-acquired pneumonia and its long-term results
Authors: Kostinov M. P. , Gainitdinova V. V. , Kazharova S. V. , Vlasenko A. E. , Polishchuk V. B. , Allaberdina D. U.
Published: April 2024

A decrease of nonspecific body resistance, an imbalance of local and systemic immunity and a free-radical oxidation abnormality substantially contribute to the pathogenesis of community-acquired pneumonia (CAP).

Purpose: To study the efficiency of including immunomodulators into the comprehensive treatment of nonsevere community-acquired pneumonia and assess the long-term effects of the treatment conducted.

Patients (n = 55) with non-severe CAP (41 (31-48) years old, with CRB-65 score of 0.15 (0-1)) are included in the study. Group 1 (control) received only standard CAP therapy; the other two groups received immunomodulators concurrently with the standard therapy: bacterial lysate (BL) for group 2 and azoximer bromide (AzB) for group 3. TNFα and IL-6 concentration was determined on the day of visit, on day 13 and day 60 of follow-up. During 2 years, the incidence of low respiratory tract infections (LRTI) was studied in the same patients with CAP in past (n = 55). All patients (n = 55) had clinical signs of non-severe community-acquired pneumonia. The overall duration of all symptoms was lower in immunomodulators groups as compared to the control group: 12 (11-13) days in BL group (p < 0.001) and 12 (11-12) days in AzB group (p < 0.001) with no statistically significant difference between intervention groups (p = 0.36). During treatment, TNFα and IL-6 concentration decreased on day 13 and day 60 in all patients; in patients who received immunomodulators, TNFα and IL-6 were reliably lower as compared to the control. Changes of TNFα and IL-6 concentration in the groups on day 60 of the study as compared to the baseline showed a decrease in BL group by 85 (-89 – -82) % and 86 (-90 – -85) % (p < 0.001; p = 0.001 and control); in AzB group by 82 (-86 – -80) % and 86 (-88 – -84) % (p = 0.002; p = 0.007 and control). Intensity of IL-6 concentration decrease on day 60 in BL and AzB groups did not differ (p = 0.72). Gender- and age-adjusted odds ratio for the development of low respiratory tract diseases (during 2 years after CAP) in AzB group was 0.15 (0.02-0.93) (p = 0.04) suggesting its protective effect. Inclusion of immunomodulators in basic treatment of non-severe community-acquired pneumonia reduces duration of symptoms and is associated with improvement of the proinflammatory cytokine profile. In 2 years of follow-up, long-term effects of the immunomodulatory therapy showed statistically significant lower incidence of low respiratory tract infections in AzB group only.
Role of non-canonical T cells in homeostasis and pathology
Authors: Toptygina A. P.
Published: April 2024

In addition to the subsets of T lymphocytes and innate lymphocytes (innate lymphoid cells), the well-known players in adaptive immunity, there is an intermediate group of lymphocytes (innate-like cells) that already possess the T cell receptor, but with a restricted repertoire. This group includes γδT cells, subsets of type I and II NKT cells carrying both T cell receptor and NK-cell receptors, and mucosal-associated invariant T (MAIT) cells. The development of innate-like cells occurs in the thymus, but their positive and negative selection takes place without the participation of thymic epithelial cells. A distinctive feature is that innate-like cells acquire an effector phenotype already in the thymus, and therefore do not require complex activation reactions during antigen recognition. Upon exit from the thymus, noncanonical T cells express chemokine receptors, allowing them to migrate into barrier tissues at an early age. A characteristic feature of the T cell receptor innate-like cells is the recognition of non-peptide antigens presented in non-polymorphic histocompatibility molecules (MHC-Ib). This type of molecule includes the CD1 a/b/c/d/e molecule and the MR1 molecule. These molecules present lipid, glycolipid antigens and metabolites of B vitamins, synthesized by various representatives of the microbiota. The presence of functionally different subpopulations of innate-like cells with an activated phenotype allows them to quickly respond to the antigen by producing cytokines typical of Th1, Th2, Th17. They also exhibit cytotoxic and immunoregulatory activity. These cells are actively involved in regulation of barrier tissue homeostasis and interaction with microbiota. They synthesize growth factors for epithelial cells, fibroblasts, and vascular endothelium, which are required for regeneration of damaged tissues. They also participate in anti-infectious defense, directing the development of the immune response. Moreover, they have been found to be involved in many autoimmune diseases. The special functions of innate-like cells make them a promising target for therapeutic interventions. It has been shown that antibiotics, salicylates and some other well-known drugs exert certain effects on the innate-like cells. Different dietary options also affect the activity of these cells.
The role of Pseudomonas aeruginosa pneumonia in the development of cardiovascular events in patients with heart failure
Authors: Podzolkov V. I. , Tarzimanova A. I. , Ponomareva L. A. , Ivannikov A. A. , Chinova A. A. , Popova E. N. , Ponomarev A. B. , Morozova O. A. , Gladun L. G. , Isaeva A. Yu.
Published: April 2024

Aim. To assess the contribution of Pseudomonas aeruginosa pneumonia to the development of cardiovascular events in patients with heart failure (HF).

Material and methods. The study included 219 patients who were divided into a group of patients with pneumonia caused by P. aeruginosa (Group I) and a group of patients with pneumonia caused by S. aureus, S. pneumoniae (Group II). All patients underwent chest computed tomography (CT), blood tests, echocardiography, electrocardiography (ECG), 24-hour Holter ECG monitoring, pulse oximetry (SpO2), and Doppler ultrasound of the lower limb veins.

Results. According to the study, cardiovascular events were more often observed in the group of patients with P. aeruginosa pneumonia as follows: death from cardiovascular events was registered in 11,4% of patients in group I and 0% of patients in group II (p=0,001); acute coronary syndrome — in 8,7 vs 0% (p=0,002), lower limb thrombosis — in 14 vs 1,9% (p=0,001). The occurrence of P. aeruginosa pneumonia in patients with HF increased the cardiovascular death risk by 8,8 times (95% confidence interval (CI): 1,2-65,7; p=0,005), acute coronary syndrome — in 8,0 times (95% CI: 1,1-60,2; p=0,014), lower limb thrombosis — in 9,6 times (95% CI: 1,3-71,2; p=0,004).

Conclusion. Patients with HF and P. aeruginosa pneumonia are at greater risk of cardiovascular events than patients with pneumonia caused by S. pneumonia and S. aureus.
UNRAVELLING THE ROLE OF ENERGETIC POLYBENZOXAZINES IN MODERN REACTIVE STRUCTURE MATERIALS
Authors: Derradji Mehdi
Published: April 2024

The development of polymers suitable to be used as reactive structure materials has been seen as a long path with major obstacles. This was due to the lack of monomers and polymers combining both the structural rigidity along with appropriate energetic performances. Hopefully, a new era is starting to emerge thanks to the dedicated work of several talented researchers around the world. The energetic polybenzoxazines discussed in this article provide a good substitute to the polyoxetanes in the field of reactive structure materials and can effectively and safely combine high thermomechanical properties and sufficient detonation properties. Therefore, this work not only unravels to enormous potential of the polybenzoxazines in the energetic field, but also effectively reviews all the previous efforts aiming at developing reactive structure materials with high glass transition temperatures. This also seeks to consolidate the existing research findings in this area, with the goal of emphasizing the potential of these materials and their significance in the future development of energetic materials.
Verification of the presence of superabsorbent polymers (SAP) in fresh concrete: results of an interlaboratory study of RILEM TC 260-RSC
Authors: Wyrzykowski Mateusz , Schroefl Christof , Toropovs Nikolajs , Lura Pietro , Snoeck Didier , Bettencourt Ribeiro António , Kara De Maeijer Patricia , Moon Juhyuk , Assmann Alexander , Igarashi Shin-Ichi , Klemm Agnieszka , Almeida Fernando C. R. , Boshoff Billy , Erk Kendra A. , Falikman Vyatcheslav , Agostinho Livia Borba , Mechtcherine Viktor
Published: April 2024

New methods are proposed for the verification of the presence of superabsorbent polymers (SAP) in freshly mixed concrete and estimation of SAP quantity. The methods are in general based on flushing concrete with excess water. They allow separating the light, water-sorbed hydrogel particles from the mineral components in the fresh concrete and making these particles available for further tests. Two types of tests are proposed: Test 1 serves for a visual verification of the presence of SAP (qualitative test), while Test 2 enables quantifying the mass of the collected SAP as a proxy of their concentration in concrete (quantitative test). Different procedures are proposed for these two test methods and their performance is evaluated. The testing procedures were scrutinized in an interlaboratory study carried out by 14 participants from 12 countries. All participating groups detected the presence of SAP in the mix using the qualitative procedures (Test 1). Based on this outcome, we suggest that this method should be applied in the field. In contrast, while most participants obtained reasonably reliable results with the quantification procedure of Test 2, some participants reported large errors. Therefore, the quantification method needs to be further refined, starting from the experience gained in this interlaboratory study.
Application of variational mode decomposition in vibration-based bridge damage detection
Authors: Shandiz Shahrooz Khalkhali
Published: April 2024

Bridges are critical infrastructure that require continuous structural health monitoring to ensure safety. Vibration-based methods use changes in dynamic response for damage detection. In this study, variational mode decomposition (VMD), a signal analysis technique, was applied to detect damage in a three-span beam bridge model subjected to moving loads. A finite-element model was developed to represent the bridge–vehicle interaction and damage was simulated by reducing the flexural stiffness of the bridge. Sensors placed on each span recorded the vibrations during vehicle passage. VMD was used to decompose the signals for analysis of damage indications. Different damage levels (30–50% stiffness reduction) and locations (each span) were evaluated. The vehicle speed was also varied to assess its effect. Damage was identified as peaks in the instantaneous energy diagrams of decomposed signals, correctly indicating the axle locations. Detection was improved with sensors nearer the damage and lower vehicle speed. The results demonstrate the ability of VMD to detect and locate damage without a baseline, indicating its potential as a non-baseline vibration-based damage detection method for bridges.
Bitcoin Price Prediction with Fuzzy Logic
Authors: Ozdemir Gulcihan
Published: April 2024

Due to cryptocurrencies' rising prices, like bitcoin, more and more people are becoming interested in them. Success in this business depends on a good price prediction. Several methods, including heuristic and machine-learning-based ones, can currently estimate the price with varied degrees of success. This study will use the Adaptive Neuro-Fuzzy Inference Systems (ANFIS) model to predict the price's general direction over the next 10 days. Along with popular traders' indicators, the previous day's price will be used. The findings demonstrated that, despite errors, price direction predictions—an increase, a drop, or a stable price—are typically accurate.
DFT Calculations, Molecular Docking, and Pharmacological Properties Investigation for 5-Benzoxazolecarboxylic Acid as a Target Anti-Cancer Agent
Authors: Küçük Ceyhun
Published: April 2024

In this study, the electronic properties of the 5-Benzoxazolecarboxylic acid molecule, a benzoxazole derivative, were calculated at the DFT/B3LYP/6-311++G(d,p) level of theory. Electronic properties and chemical reactivity of the optimized structure, such as Frontier molecular orbital (FMO), global and chemical reactivity descriptors, molecular electrostatic potential (MEP), and charge analyses (APT, Hirshfeld, and NBO), were investigated. Also, electronic properties are supported by electron localization function (ELF) and localized orbital locator (LOL) analyses. Toxicity effects such as mutagenic, tumorigenic, irritant, reproductive effect, and physicochemical properties such as druglikeness and drugscore were investigated. Molecular docking studies were conducted with the vascular endothelial growth factor receptor VEGFR-2 and the PARP-2 inhibitor, which is involved in many critical cellular processes, including DNA single-stranded fracture repair and cell death control, and its effectiveness in cancer treatment was investigated.
VARIANTS FOR RETRANSLATION CLASSIC WORKS OF LITERATURE (BY THE EXAMPLE OF W. SHAKESPEARE'S SONNET 116)
Authors: Efremova Lyudmila , Lashkova Galina
Published: April 2024

The article presents part of the research on retranslation in modern translation studies both in Russia and abroad. Some factors and causes are characterised as being important for choosing world classical works of literature, namely the status of the author and his/her creative works in the world community, his/her popularity at a certain time of the society development, the obsolescence of previous translations, from the view point of modern cultural realia, the aim of the translator to present his/her interpretation of the original text, etc. Of great importance is the study of William Shakespeare’s works who is a world literature classic. The translations of Shakespeare’s works into Russian are considered to be the best translations from English into a foreign language. The article analyses the degree of translation’s adequacy which is one of the most important criteria of translation quality.
The reproductive biology of Marathrum rubrum Novelo & C. T. Philbrick: morphological and anatomical changes during flower development
Authors: Guzmán-Merodio Diana , Luna-Ramos Raúl , Núñez-Farfán Juan , Collazo-Ortega Margarita , Márquez-Guzmán Judith
Published: April 2024

Background: Podostemaceae is the largest family of strictly aquatic angiosperms. Species of this family possess unusual morphological and reproductive characters, grow attached to rocks in rivers with strong currents, and have a life cycle tightly linked to seasonality. Due to its reduced floral structures, which characterizes most species, the analysis of developmental stages and events such as anthesis or stigma receptivity has proven difficult.
Question: How floral morphology, floral development and stigma receptivity of different stages of flower development of Marathrum rubrum Novelo & C. T. Philbrick are related among them?
Studied species: Marathrum rubrum Novelo & C. T. Philbrick.
Study site and dates: Horcones River, Jalisco, Mexico. January, 2014 and 2015.
Methods: We made an in situ and lab analyses of flower morphology to assess the relationships between flower morphology, stages of development, reproductive structures, and stigma receptivity, during different stages of flower development.
Results: When flowers emerge from the spathella, both the ovules and pollen grains are fully developed, implying that sporogenesis and gametogenesis take place within the stem while the plant is still submerged.
Conclusions: The morphological changes observed in the flowers of M. rubrum during the analyzed stages are related only to events associated with fertilization and fruit development. The time-course of morphological changes in the flowers, from anthesis to fruit formation, lasts 20 to 30 days. The detailed observation of the aerial reproductive biology of M. rubrum bears important implications to the genetic structure of populations, plant fitness and conservation biology in threatened environments.
Post-fire regeneration of oak-pine forest across a chronosequence in western Mexico: key species for forest restoration
Authors: Atondo-Bueno Edel Joshua , Zuloaga-Aguilar Susana , Muñiz-Castro Miguel Ángel , Cuevas-Guzmán Ramón , López-Barrera Fabiola , Alanís-Rodríguez Eduardo
Published: April 2024

Background: High-severity fires are serious anthropogenic threats to forests, as they can cause forest degradation on unrecoverable scales. Therefore, understanding the patterns and drivers of post-fire regeneration is essential to designing restoration proposals.
Hypotheses: After a high-severity fire, we expected greater species richness and abundance of individuals in flat sites than in hillside sites since seeds, nutrients, and organic matter accumulate in flat landforms. Compared to some Pinus species, Quercus species are more drought-tolerant after a forest fire and, therefore, they are expected to dominate post-fire chronosequences.
Study site: The study was conducted in the “La Primavera” Flora and Fauna Protection Area.
Methods: We sampled vegetation and microenvironmental variables from 2021 to 2022 at 18 sites located on flat and hillside areas, at 3, 9, and ≥ 20 years since the last high-severity forest fires (TSF).
Results: The richness of woody and herbaceous species was higher at 3 TSF and 9 TSF. The topographic condition did not significantly drive the richness and abundance of woody species, but richness and abundance of herbaceous species were significantly greater in flat sites. The oak tree Quercus resinosa Liebm. was the dominant species throughout the chronosequence.
Conclusions: Quercus resinosa represents a foundational species for recovering forest structure and composition. Flat sites may act as regeneration nuclei, but hillside sites require greater restoration efforts.
ИСТОРИЯ РАЗВИТИЯ СОБСТВЕННЫХ ТОРГОВЫХ МАРОК В АПТЕЧНОМ РИТЕЙЛЕ
Authors:   Воронежский государственный университет, ЖУРАВЛЕВА Т.И. , ЧУПАНДИНА Е.Е.
Published: April 2024

Одним из факторов успеха компаний является наличие сильного узнаваемого бренда и впоследствии реализация продукции собственной торговой марки (далее - СТМ). История СТМ в продовольственном ритейле началась в конце XIX в. с реализации бекона под торговым наименованием компании в Великобритании. В России впервые СТМ ввел в свой ассортимент супермаркет «Перекресток» в 2001 г., предлагая своим покупателям воду в объеме 5 л. Впервые товары СТМ в аптечный ритейл были введены компанией «36,6» в 2004 г., на тот момент это были самые распространённые ассортиментные позиции по «сносной цене». В 2012 г. в ассортименте уже 10 компаний имели продукцию СТМ. Сейчас направление СТМ является динамичным и быстроразвивающимся: в ассортиментном портфеле некоторый компаний насчитывается свыше 2000 ассортиментных позиций СТМ, ежегодно организуется Международная премия по контрактному производству. Было установлено, что на региональном рынке (на примере г. Воронежа) из 30 исследуемых аптечных организаций (далее - АО) в своем ассортименте имеют продукцию СТМ - 20 компаний. Введение продукции СТМ в ассортимент является одной из стратегий устойчивости компаний, поскольку позволяет повысить рентабельность бизнеса и выделить свою компанию среди конкурентов.
ИССЛЕДОВАНИЕ ПОКАЗАТЕЛЕЙ ЗАБОЛЕВАЕМОСТИ НАСЕЛЕНИЯ ВОРОНЕЖСКОЙ ОБЛАСТИ НОВООБРАЗОВАНИЯМИ
Authors:   Воронежский государственный университет, КУРОЛАП М.С. , МАЛЕВА А.Б. , ЧУПАНДИНА Е.Е.
Published: April 2024

Целью исследования выступил анализ показателей заболеваемости новообразованиями населения Воронежской области за 20-ти летний период (2001 - 2020 гг.). Информационная база исследования: статистические данные Департамента здравоохранения Воронежской области. Методы исследования: картографический, расчетно аналитический. Анализ динамики общей заболеваемости населения новообразованиями выявил ежегодный рост и общий прирост за 20 лет по взрослому населению составил 14,4%, по подросткам 109%, по детям 92,4%. Группировка районов Воронежской области по уровню заболеваемости новообразованиями и картографический анализ полученных результатов среди взрослого и детского населения выявил наиболее проблемные районы - Аннинский, Репьевский, Эртильский (взрослые) и Семилукский, Новоусманский (дети).
ФАРМАЦЕВТИЧЕСКАЯ ОТРАСЛЬ: ТОВАРОВЕДЧЕСКИЙ АНАЛИЗ ФИЗИЧЕСКОЙ ДОСТУПНОСТИ ЛЕКАРСТВЕННЫХ ФОРМ ОГРАНИЧИТЕЛЬНЫХ ПЕРЕЧНЕЙ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ
Authors:   Орловский государственный университет имени И. С. Тургенева, САМОЩЕНКОВА И.Ф. , КОНДРАТОВА Д.В. , ЦЫГАНОВ В.С. , ЛЕБЕДЕВ И.А. , ГАРАНКИНА Р.Ю. ,   Первый Московский государственный медицинский университет имени И.М. Сеченова
Published: April 2024

За счет формирования и реализации утвержденных ограничительных перечней ЛП, обеспечивается в первую очередь доступность ЛП и качество гарантированной лекарственной помощи для населения. Перечень препаратов минимального ассортимента (МАЛП) динамичен. С каждым годом ассортимент МАЛП либо дополняют новые препараты для лечения различных патологий, либо не востребованные исключаются из списка. Ответственность за наличие препаратов минимального ассортимента должна ложиться между всеми участниками процесса закупок, включая производителей и оптовых поставщиков, т.к. наказывать за отсутствие каких-либо лекарств из перечня только аптеки несправедливо, поскольку они находятся в прямой зависимости от дистрибьюторов и фармпроизводителей.
ИССЛЕДОВАНИЕ ДИУРЕТИЧЕСКОЙ АКТИВНОСТИ ДОРУСИМ
Authors:   Ташкентская медицинская академия, ХАКИМОВ З.З. , РАХМАНОВ А.Х. , БАБАЖАНОВ А.У. , ТУРСУНОВА Л.И. ,   Узбекский научно-исследовательский химико-фармацевтический институт им А. Султанова
Published: April 2024

В экспериментальных исследованиях показано отчетливая диуретическая активность фито композиции дорусима равной экустиму, а при экспериментальном асептическом цистите не уступает фито препарату канефрону. Считают, что фито композиция дорусим может быть рекомендован в качестве патогенетического средства для лечения острых циститов.
THE EFFECT OF NEW TEMOZOLOMIDE ANALOGUES ON APOPTOSIS OF TUMOR CELL LINES TO JUSTIFY THE CREATION OF DRUGS FOR THE TREATMENT OF ONCOLOGICAL DISEASES
Authors:   Volgograd State Medical University, AL-HUMAIRI A.H.
Published: April 2024

The purpose of the study was to study the cytostatic activity of temozolomide analogues in vitro. The MTT test method was usedfor the study. The compounds were used in final concentrations from 0.25 to 10.0 mmol/l.The obtained data can be used as a basis for the selection of substances for further to study their genotoxic and metabolic properties on cell models and laboratory animals as substances with antitumor activity
ИЗУЧЕНИЕ ВЛИЯНИЯ ГУСТЫХ ЭКСТРАКТОВ ПОБЕГОВ БОЯРЫШНИКА НА ВЫДЕЛИТЕЛЬНУЮ ФУНКЦИЮ ПОЧЕК
Authors:   Самарский государственный медицинский университет, ЗАЙЦЕВА Е.Н. , ВОЛКОВА Н.А. , ЦИБИНА А.С. , АЛТАРЕВА А.И. , ШАРОВА О.В.
Published: April 2024

Плоды и цветки боярышника применяют в качестве лекарственного растительного сырья для получения кардиотонических средств. Одним из возможных видов сырья боярышника для получения лекарственных препаратов являются побеги первого года, собранные на стадии цветения растения. Цель исследования - изучение выделительной работы почек на фоне введения густых экстрактов, полученных на основе побегов боярышника кроваво-красного (Crataegus sanguinea Pall.) и боярышника мягковатого (Crataegus submollis Sarg.). Полученные результаты свидетельствует о креатининуретическом действии исследуемых густых экстрактов. Густой экстракт побегов боярышника кроваво-красного в дозе 10 мг/кг достоверно увеличивает креатининурез за 4 и 24 часа эксперимента, густой экстракт побегов боярышника мягковатого в аналогичной дозе достоверно увеличивает креатининурез только за 4 часа эксперимента.
ОСОБЕННОСТИ ПОЛУСИСТЕМАТИЧЕСКИХ ЛАТИНСКИХ НАЗВАНИЙ ЛЕКАРСТВЕННЫХ ВЕЩЕСТВ В Г ОСУДАРСТВЕННОЙ ФАРМАКОПЕЕ РФ XIV ИЗДАНИЯ
Authors:   Воронежский государственный университет, ТУРОВСКИЙ А.В.
Published: April 2024

Рассматриваются особенности терминологического оформления полусистематических химизированных латинских названий лекарственных веществ в ГФ РФ XIV издания и соответствие их грамматике латинского языка и современной химической номенклатуре
Tinnitus in children – diagnosis and management
Authors: Mazurek Łukasz , Raj-Koziak Danuta
Published: April 2024

Szumy uszne u dzieci występują dużo częściej niż są rozpoznawane, ponieważ dzieci nie potrafią w sposób jasny wyrazić swoich dolegliwości. Na podstawie analizy dostępnego piśmiennictwa, zaleceń Brytyjskiego Towarzystwa Audiologicznego (British Society of Audiology) przygotowanego we współpracy z grupą roboczą (Pediatric Tinnitus Working Group) oraz doświadczeń własnych przedstawiono charakterystykę dziecięcych szumów usznych, ich wpływ na różne aspekty życia pacjentów pediatrycznych oraz zalecenia diagnostyczne. Ponadto omówiono sposoby postępowania i terapii szumów usznych u dzieci.
Problems of hyperacusis and misophonia occurring in patients with tinnitus
Authors: Raj-Koziak Danuta , Gos Elżbieta , Kutyba Justyna , Skarżyński Piotr H. , Skarżyński Henryk
Published: April 2024

Wprowadzenie

Nadwrażliwość słuchowa i mizofonia to rodzaje obniżonej tolerancji na dźwięk. Obie te dysfunkcje mają pewne cechy wspólne, jednak każda z nich ma swoją specyfikę. Szczególnie często występują w przebiegu szumów usznych, stanowiąc dodatkową dolegliwość dla pacjentów. Celem pracy jest określenie rodzaju i nasilenia problemów związanych z obniżoną tolerancją na dźwięki, tj. nadwrażliwością słuchową i mizofonią, zgłaszanych przez pacjentów z szumami usznymi.

Materiał i metody

W badaniu wzięło udział 101 pacjentów (54 kobiety i 47 mężczyzn) z szumami usznymi, w wieku od 19 do 72 lat. Wszyscy zgłaszali dodatkowe problemy związane z obniżoną tolerancją na dźwięki. Badanie audiologiczne obejmowało: wywiad, wideootoskopię, audiometrię tonalną i impedancyjną oraz ocenę poziomu nieprzyjemnego słyszenia. Pacjenci wypełniali: Kwestionariusz uciążliwości szumów usznych (THI), Wizualną skalę analogową (VAS) oraz autorski Kwestionariusz nadwrażliwości słuchowej (KNS).

Wyniki

Progi słyszenia wynosiły przeciętnie około 16–18 dB HL dla przewodnictwa powietrznego i około 10 dB HL dla przewodnictwa kostnego. Prawidłowe wynik tympanometrii stwierdzono
u 97% pacjentów. Przeciętny próg dyskomfortu wynosił około 72–76 dB HL. Stwierdzono korelację między uciążliwością szumów usznych a nadwrażliwością słuchową (rho = 0,31), natomiast brak było związku między uciążliwością szumów usznych a mizofonią (rho = 0,04).

Wnioski

Nadwrażliwość słuchowa oraz mizofonia, będące rodzajem obniżonej tolerancji na dźwięki, często współwystępują z szumami usznymi. W praktyce klinicznej powinny być różnicowane
i wskazane jest, by ich diagnostyka i terapia były prowadzone przez wielodyscyplinarny zespół specjalistów.
Review of mobile apps for self-testing of hearing in Polish language
Authors: Pastucha Małgorzata , Kochanek Krzysztof , Piłka Edyta , Jędrzejczak Wiesław W.
Published: April 2024

Wstęp

Dynamiczny rozwój technologii informacyjno-komunikacyjnych stanowi ogromny potencjał dla obszaru opieki zdrowotnej. Pozwala on na wdrażanie nowoczesnych rozwiązań, które mogą być pomocne w usprawnianiu usług związanych ze zdrowiem. Należą do nich m.in. aplikacje mobilne, których liczba wzrasta z każdym rokiem. Efektem tego jest szybki rozwój rynku aplikacji, a ich powszechna dostępność sprawia, że już teraz są wykorzystywane m.in. do wstępnej samooceny słuchu, a w przyszłości mogą wspomóc klasyczne badania przesiewowe wykonywane z użyciem specjalnych urządzeń. Celem pracy było zidentyfikowanie dostępnych aplikacji mobilnych w języku polskim umożliwiających wyznaczenie progu słyszenia.

Materiał i metody

Przeglądu dokonano z wykorzystaniem platformy Google Play Store. Do dalszej analizy włączono darmowe aplikacje w języku polskim służące do wyznaczania progu słyszenia.

Wyniki

W wyniku wyszukiwania zidentyfikowano 5 aplikacji spełniających kryteria włączenia, czyli umożliwiających m.in. wykonanie audiometrii tonalnej (AT) w standardowym zakresie częstotliwości (do 8000 Hz). Dodatkowo aplikacja „Badanie słuchu e-audiologia.pl”
pozwala na wyznaczenie progu słyszenia także dla wyższych częstotliwości (10 000–18 000 Hz) oraz na sprawdzenie zrozumiałości mowy w szumie. Żadna ze znalezionych aplikacji nie zawiera funkcjonalności, która umożliwiałaby wykonanie tzw. audiometrii zabawowej, wykorzystywanej do badania słuchu małych dzieci.

Wnioski

Na rynku istnieje kilka aplikacji mobilnych, które mogą służyć do samooceny słuchu. Dużą lukę, zwłaszcza na rynku polskim, stanowi zupełny brak aplikacji mobilnych, dzięki którym możliwe byłoby wyznaczenie progu słyszenia u dzieci za pomocą tzw. audiometrii zabawowej.
La medición de la vulnerabilidad en las dimensiones de la sostenibilidad. Apuntes desde la infrarrepresentación de las ciencias sociales
Authors: Masdeu-Valdivia Mireia , García-Parra Raquel , Relinque Medina Fernando
Published: April 2024

La calidad de la medición de la vulnerabilidad ambiental, económica y social ante fenómenos naturales adversos y ante el cambio climático es primordial para un diagnóstico, con un enfoque integral, de los riesgos e impactos que permita el desarrollo de estrategias de desarrollo sostenible eficientes y adaptadas a las características socioespaciales del territorio en el que se implementen. Sin embargo, los estudios científicos de vulnerabilidad de estos fenómenos ambientales están siendo desarrollados principalmente por áreas de investigación relacionadas con las ciencias físicas y naturales, ocupando las ciencias sociales una clara posición de desventaja en este ámbito. Los resultados muestran cómo esta infrarrepresentación de las ciencias sociales está favoreciendo evaluaciones de vulnerabilidad sesgados, con sistemas de indicadores incompletos, que ponen en riesgo un diagnóstico correcto de la situación de vulnerabilidad social, lo que puede derivar en políticas y estrategias de sostenibilidad que no se ajusten a las necesidades los territorios que sufren las consecuencias no deseadas de estos fenómenos y que afectan, con especial virulencia, a la población con mayor índice de vulnerabilidad social.
Identification of microorganisms in wet coffee fermentation Coffea arabica Var Catimor and Castillo in Jardín, Antioquia-Colombia, using culture-dependent methods
Authors:   Universidad de Antioquia, Motato Rocha Karina Edith , Gonzalez-Montero Valentina ,   Universidad de Antioquia, Román-Morales María Orfilia ,   Universidad de Antioquia
Published: April 2024

Background: Mild Colombian coffees are recognized worldwide for their high-quality coffee cup. However, there have been some failures in post-harvest practices, such as coffee grain fermentation. These failures could occasionally lead to defects and inconsistencies in quality products and economic losses for coffee farmers. In Colombia, one of the fermentation methods most used by coffee growers is wet fermentation, conducted by submerging the de-pulped coffee beans for enough time in water tanks to remove the mucilage. Objectives: We evaluated the effect of the water (g)/de-pulped coffee (g) ratio (I: 0/25, II: 10/25, III: 20/25) and final fermentation time (24, 48, and 72 hours) on the total number of microbial groups. We also identified microorganisms of interest as starter cultures. Methods: We used a completely randomized experimental design with two factors; the effect of the water (g)/de-pulped coffee (g) ratio (I: 0/25, II: 10/25, III: 20/25) and final fermentation time (24, 48, and 72 hours), for 9 treatments with two replicates. During the coffee fermentation (1,950 g), the pH and °Brix were monitored. Total counts of different microbial groups (mesophiles, coliforms, lactic-acid bacteria, acetic-acid bacteria, and yeasts) were performed. Various isolates of microorganisms of interest as starter cultures (lactic-acid bacteria and yeasts) were identified using molecular sequencing techniques. Results: 21 lactic-acid bacteria (LAB) isolates and 22 yeasts were obtained from the different mini-batch fermentation systems. The most abundant lactic-acid bacteria species found were Lactiplantibacillus plantarum (46%) and Levilactobacillus brevis (31%). Pichia kluivery (39%) and Torulaspora delbrueckii (22%) were the most abundant yeast species. Conclusion The studied factors did not have effect over the microorganism’s development. The identified bacterial and yeasts species have potential as starter cultures for better-quality coffees and in fermentation-related applications.
Review of LoRaWAN: Performance, Key Issues and Future Perspectives
Authors:   Department of Electrical and Electronic Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Malaysia, Che Kamarudin Muhammad Naim , Ayob Afida ,   Department of Electrical and Electronic Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Malaysia, Hussain Aini ,   Department of Electrical and Electronic Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Malaysia, Ansari Shaheer ,   Department of Electrical and Electronic Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Malaysia, Abdolrasol Maher. G. M. ,   Department of Electrical and Electronic Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Malaysia, Md Saad Mohamad Hanif ,   Department of Mechanical and Manufacturing Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Malaysia
Published: April 2024

In the last few years, the Low-powered wide area networks (LPWAN) have gained popularity and massively deployed, especially in smart cities and agriculture, due to their advantages, such as energy efficiency, extensive coverage, and low cost. The long-range wide area networks (LoRaWAN) protocol is a new technology. It attracts the attention of many research centers worldwide as it allows data transmission at a low cost across long distances. This article reviews the performance of LoRa and LoRaWAN for both investigations in indoor and outdoor environments. Moreover, a performance analysis of this technology is made by focusing on five main indicators, which are coverage, time on air (TOA), packet error rate (PER), received signal strength indication (RSSI), and signal-to-noise ratio (SNR) while considering technical characteristics is included. The investigation settings were divided into two categories: simulation and testbed in a real-world application. Consequently, a table of summary of indicators used by the researcher was made to make it easier for other researchers to find references for their topics relevant to this review. Next, the identified key issues and solutions are discussed in this review. The issues discussed significantly affect the performance of various monitoring technologies regarding energy management, quality of service, coverage, signal interference, and data handling. Finally, this review will discuss the future perspective, provide valuable suggestions for future research works, and lead toward improving current LoRaWAN technology.
Assessing Cleaning in Remanufacturing: A Case Study of Shot Blasting Efficiency to Alternator Design
Authors:   Department of Mechanical and Manufacturing Engineering, Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia, Abdul Malek Noraini , Abd Wahab Dzuraidah ,   Department of Mechanical and Manufacturing Engineering, Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia, Harun Zambri ,   Department of Mechanical and Manufacturing Engineering, Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia, Abd Aziz Nurhasyimah ,   Department of Mechanical and Manufacturing Engineering, Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia, Azman Abdul Hadi ,   Department of Mechanical and Manufacturing Engineering, Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia, Abu Mansor Mohd Radzi ,   Department of Mechanical and Manufacturing Engineering, Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia
Published: April 2024

Cleaning is a crucial step in the remanufacturing of end-of-life components. The main purpose of cleaning is to remove all contaminant items such as dirt, oils, dust in order to facilitate the process of core inspection before moving on to the subsequent step to complete the remanufacturing activity. However, there are issues/challenges related to the cleaning methods that affect the process efficiency. It has also been reported that the cleaning process is time consuming and has adverse impact to the environment. Cleaning is directly influenced by the various cleaning methods and the design features of each core/incoming parts. Therefore, the aim of this paper is to evaluate the effectiveness of shot blasting cleaning method from core design perspectives in the case of an alternator. The results will be assessed based cleanliness level after the cleaning process on the core surface, complex shape, geometry, and joining method. The outcome demonstrates that the complexity of the core design also affects the cleaning process efficiency. According to the study shot blasting cleaning method without any pretreatment process was insufficient to fully clean the core. Hence, it is suggested to consider several parameters to enhance the shot blasting method to clean the used alternator for remanufacturing process.
Method and Use in Implementation of Integration BIM and GIS and Its Potential in the Drainage System Management: A Review
Authors:   Jabatan Kejuruteraan Awam, Fakulti Kejuruteraan dan Alam Bina, Universiti Kebangsaan Malaysia, 43650, UKM Bangi, Selangor Malaysia, Ahmad Abdullah ,   Cawangan Dasar dan Pengurusan Korporat, Jabatan Kerja Raya Malaysia, Menara Kerja Raya, Ibu Pejabat JKR, Jalan Sultan Salahuddin, 50480 Kuala Lumpur, Abdul Maulud Khairul Nizam ,   Jabatan Kejuruteraan Awam, Fakulti Kejuruteraan dan Alam Bina, Universiti Kebangsaan Malaysia, 43650, UKM Bangi, Selangor Malaysia,   Pusat Pencerapan Bumi, Institut Perubahan Iklim, Universiti Kebangsaan Malaysia, 43650, UKM Bangi, Selangor Malaysia, Syed Abdul Rahman Syed Ahmad Fadhli ,   Pusat Pencerapan Bumi, Institut Perubahan Iklim, Universiti Kebangsaan Malaysia, 43650, UKM Bangi, Selangor Malaysia,   Bahagian Kadaster, Jabatan Ukur dan Pemetaan Malaysia, 50578 Kuala Lumpur
Published: April 2024

The ability of Geographic Information System (GIS) applications to manage three-dimensional (3D) data is increasing along with advancements in current technology, and this ability can be further enhanced through the integration of Building Information Modeling (BIM) technology. While the combination of BIM and GIS technologies provides significant benefits to human life, there are several challenges and limitations that need to be addressed for successful implementation. Therefore, research on previous articles will be conducted to examine the challenges and potential of this integration. This paper will begin with searching for relevant previous articles using appropriate keywords on Web of Science and Scopus. The search will be conducted in two parts, articles related to BIM-GIS integration with keywords "BIM" AND "GIS," and articles concerning the usage of 3D data in GIS applications for drainage system management using keywords "GIS" AND "3D" AND "DRAINAGE." From these articles, observations will be made regarding (1) the structure of BIM-GIS integration data, (2) implemented integration methods, (3) utilization of integration models, and (4) the potential of BIM-GIS Integration in managing 3D drainage system data. The research identifies key challenges in BIM-GIS integration, including differences in class numbers, dissimilar class arrangement, geometry creation methods, and georeference system application. To address these challenges, standard protocols based on specific requirements need to be established by considering organizational needs to ensure a consistent integration process. The paper also recognizes significant potential in employing BIM-GIS integration for drainage system management.
Semi-Transparent PV and Double-Glazed Windows for Heat Reduction and Electricity Generation: A Study for Office Buildings in Tropical Climate
Authors:   Department of Electrical Engineering, Universitas Islam Negeri Sultan Syarif Kasim Riau, 28293, Pekanbaru, Indonesia, Jelita Marhama , - Miftahuddin ,   Department of Islamic Guidance and Counselling, Universitas Islam Negeri Sultan Syarif Kasim Riau, 28293, Pekanbaru, Indonesia, - Suhaimi ,   Department of Islamic Guidance and Counselling, Universitas Islam Negeri Sultan Syarif Kasim Riau, 28293, Pekanbaru, Indonesia, Saleh Habibis ,   Mathematics Education Department, Universitas Islam Negeri Sultan Syarif Kasim Riau, 28293, Pekanbaru, Indonesia
Published: April 2024

This research aims to develop a methodology for the evaluation of the potential energy saving and energy generation of semi-transparent PV and double-glazed window in Indonesia office buildings. The evaluation is based on Comsol software. The heat transfer equations for the inside the enclosure between the glass have been constructed according to the natural convection equation. The simulations were accomplished for four orientations from January until December and compared to a single-glazed window. The results show that it is possible to reduce the energy consumption for artificial lighting and air-conditioning using appropriate control systems and furthermore to generate electricity using semi-transparent photovoltaic panels in windows. The use of semi-transparent PV and double-glazed window has proven to be more effective in reducing heat transfer in buildings and generate electricity. East-facing double-glazed windows produce the most electricity, approximately 341 kWh.