bluuebunny/crossref_metadata_2025 huggingface dataset:
Mitochondrial Adaptations in Aged Skeletal Muscle: Effect of Exercise Training
Authors: ZIAALDINI M. M. , HOSSEINI S. R. A. , FATHI M.
Published: December 2019

The aging process is associated with a decline in mitochondrial functions. Mitochondria dysfunction is involved in initiation and progression of many health problems including neuromuscular, metabolic and cardiovascular diseases. It is well known that endurance exercise improves mitochondrial function, especially in the elderly. However, recent studies have demonstrated that resistance training lead also to substantial increases in mitochondrial function in skeletal muscle. A comprehensive understanding of the cellular mechanisms involved in the skeletal muscle mitochondrial adaptations to exercise training in healthy elderly subjects, can help practitioners to design and prescribe more effective exercise trainings.
Resveratrol Alleviates Ethanol-Induced Hormonal and Metabolic Disturbances in the Rat
Authors: SZKUDELSKA K. , DENIZIAK M. , ROŚ P. , GWÓŹDŹ K. , SZKUDELSKI T.
Published: December 2019

Resveratrol is a polyphenol found in different plant species and having numerous health-promoting properties in animals and humans. However, its protective action against deleterious effects of ethanol is poorly elucidated. In the present study, the influence of resveratrol (10 mg/kg/day) on some hormones and metabolic parameters was determined in rats ingesting 10 % ethanol solution for two weeks. Blood levels of insulin, glucagon and adiponectin were affected by ethanol, however, resveratrol partially ameliorated these changes. Moreover, in ethanol drinking rats, liver lipid accumulation was increased, whereas resveratrol was capable of reducing liver lipid content, probably due to decrease in fatty acid synthesis. Resveratrol decreased also blood levels of triglycerides and free fatty acids and reduced γ-glutamyl transferase activity in animals ingesting ethanol. These results show that resveratrol, already at low dose, alleviates hormonal and metabolic changes induced by ethanol in the rat and may be useful in preventing and treating some consequences of alcohol consumption.
Obestatin Modulates Ghrelin’s Effects on the Basal and Stimulated Testosterone Secretion by the Testis of Rat: an In Vitro Study
Authors: AFSAR T. , JAHAN S. , RAZAK S. , ALMAJWAL A. , ABULMEATY M. , WAZIR H. , MAJEED A.
Published: December 2019

The functional antagonism between obestatin and ghrelin in the testis is under investigation. We investigated the ability of obestatin to counteract the inhibitory effect of ghrelin on basal and stimulated testosterone (T) secretion in vitro. Testicular strips from adult rats were incubated with 10 ng/ml and 100 ng/ml of obestatin alone, ghrelin alone and obestatin + ghrelin. Obestatin modulation of stimulated T secretion was evaluated by incubation of testicular samples with 10 ng/ml and 100 ng/ml obestatin, ghrelin and obestatin + ghrelin in the absence and presence of 10 IU of human chorionic gonadotrophin (hCG). T concentrations in the hCG treated groups were significantly (P<0.0001) higher than those in the control groups. Obestatin caused a significant increase in basal T secretion in a dose-dependent manner; however, obestatin at the both 10 ng/ml and 100 ng/ml significantly (P<0.0001) increased hCG-stimulated T secretion. In contrast, ghrelin in a dose-dependent manner significantly (P<0.001) decreased both basal and hCG-induced T secretion by testicular slices. Obestatin opposed the inhibitory effect of ghrelin on T secretion under both basal and hCG-stimulated conditions at all doses tested. In conclusions, administration of obestatin was able to antagonize the inhibitory effect of ghrelin on testosterone secretion in vitro.
The Molecular Genetic Background of Familial Hypercholesterolemia: Data From the Slovak Nation-Wide Survey
Authors: GABČOVÁ D. , VOHNOUT B. , STANÍKOVÁ D. , HUČKOVÁ M. , KADUROVÁ M. , DEBREOVÁ M. , KOZÁROVÁ M. , FÁBRYOVÁ Ľ. , SLOVAK FH STUDY GROUP  , STANÍK J. , KLIMEŠ I. , RAŠLOVÁ K. , GAŠPERIKOVÁ D.
Published: December 2019

Familial hypercholesterolemia (FH) is most frequently caused by LDLR or APOB mutations. Therefore, the aim of our study was to examine the genetic background of Slovak patients suspected of FH. Patients with clinical suspicion of FH (235 unrelated probands and 124 family relatives) were recruited throughout Slovakia during the years 2011-2015. The order of DNA analyses in probands was as follows: 1. APOB mutation p.Arg3527Gln by real-time PCR method, 2. direct sequencing of the LDLR gene 3. MLPA analysis of the LDLR gene. We have identified 14 probands and 2 relatives with an APOB mutation p.Arg3527Gln, and 89 probands and 75 relatives with 54 different LDLR mutations. Nine of LDLR mutations were novel (i.e. p.Asp90Glu, c.314-2A>G, p.Asp136Tyr, p.Ser177Pro, p.Lys225_Glu228delinsCysLys, p.Gly478Glu, p.Gly675Trpfs*42, p.Leu680Pro, p.Thr832Argfs*3). This is the first study on molecular genetics of FH in Slovakia encompassing the analysis of whole LDLR gene. Genetic etiology of FH was confirmed in 103 probands (43.8 %). Out of them, 86.4 % of probands carried the LDLR gene mutation and remaining 13.6 % probands carried the p.Arg3527Gln APOB mutation.
Vasodilatory Responses of Renal Interlobular Arteries to Epoxyeicosatrienoic Acids Analog Are Not Enhanced in Ren-2 Transgenic Hypertensive Rats: Evidence Against a Role of Direct Vascular Effects of Epoxyeicosatrienoic Acids in Progression of Experimental Heart Failure
Authors: SPORKOVÁ A. , HUSKOVÁ Z. , ŠKAROUPKOVÁ P. , RAMI REDDY N. , FALCK J. R. , SADOWSKI J. , ČERVENKA L.
Published: December 2019

Pathophysiological mechanisms underlying the development of renal dysfunction and progression of congestive heart failure (CHF) remain poorly understood. Recent studies have revealed striking differences in the role of epoxyeicosatrienoic acids (EETs), active products of cytochrome P-450-dependent epoxygenase pathway of arachidonic acid, in the progression of aorto-caval fistula (ACF)-induced CHF between hypertensive Ren-2 renin transgenic rats (TGR) and transgene-negative normotensive Hannover Sprague-Dawley (HanSD) controls. Both ACF TGR and ACF HanSD strains exhibited marked intrarenal EETs deficiency and impairment of renal function, and in both strains chronic pharmacologic inhibition of soluble epoxide hydrolase (sEH) (which normally degrades EETs) normalized EETs levels. However, the treatment improved the survival rate and attenuated renal function impairment in ACF TGR only. Here we aimed to establish if the reported improved renal function and attenuation of progression of CHF in ACF TGR observed after sEH blockade depends on increased vasodilatory responsiveness of renal resistance arteries to EETs. Therefore, we examined the responses of interlobar arteries from kidneys of ACF TGR and ACF HanSD rats to EET-A, a new stable 14,15-EET analog. We found that the arteries from ACF HanSD kidneys rats exhibited greater vasodilator responses when compared to the ACF TGR arteries. Hence, reduced renal vasodilatory responsiveness cannot be responsible for the lack of beneficial effects of chronic sEH inhibition on the development of renal dysfunction and progression of CHF in ACF HanSD rats.
QUANTUM CODES FROM CODES OVER THE RING $\mathbb{F}_{2^m}+\alpha \mathbb{F}_{2^m}+\beta \mathbb{F}_{2^m}+ \gamma \mathbb{F}_{2^m}$
Authors: GÜZELTEPE Murat , ERÖZ Mustafa
Published: December 2019

Let $i,j,k$ be elements of real quaternions $\mathbb{H}$. Let $\alpha , \beta , \gamma$ be the elements corresponding to $1+i, 1+j, 1+k,$ respectively. In this study,  quantum codes from classical codes over $\mathbb{F}_{2^m}+\alpha \mathbb{F}_{2^m}+\beta \mathbb{F}_{2^m}+ \gamma \mathbb{F}_{2^m}$ are obtained.
RETRACTED: Modeling Cardiac Dysfunction Following Traumatic Hemorrhage Injury: Impact on Myocardial Integrity
Authors: Wall Johanna , Naganathar Sriveena , Praditsuktavorn Banjerd , Bugg Oscar F. , McArthur Simon , Thiemermann Christoph , Tremoleda Jordi L. , Brohi Karim
Published: December 2019

Cardiac dysfunction (CD) importantly contributes to mortality in trauma patients, who survive their initial injuries following successful hemostatic resuscitation. This poor outcome has been correlated with elevated biomarkers of myocardial injury, but the pathophysiology triggering this CD remains unknown. We investigated the pathophysiology of acute CD after trauma using a mouse model of trauma hemorrhage shock (THS)-induced CD with echocardiographic guidance of fluid resuscitation, to assess the THS impact on myocardial integrity and function. Mice were subjected to trauma (soft tissue and bone fracture) and different degrees of hemorrhage severity (pressure controlled ~MABP < 35 mmHg or <65 mmHg) for 1 h, to characterize the acute impact on cardiac function. In a second study, mice were subjected to trauma and hemorrhage (MABP < 35 mmHg) for 1 h, then underwent two echocardiographic-guided resuscitations to baseline stroke volume at 60 and 120 min, and were monitored up to 180 min to study the longer impact of THS following resuscitation. Naïve and sham animals were used as controls. At 60 min post-THS injury, animals showed a lower cardiac output (CO) and stroke volume (SV) and an early rise of heart fatty acid-binding protein (H-FABP = 167 ± 38 ng/ml; 90% increase from shams, 3.54 ± 3.06 ng/ml), when subjected to severe hemorrhage and injury. Despite resuscitation, these animals maintained lower CO (6 ml/min vs. 23 ml/min), lower SV (10 μl vs. 46 μl; both ~75% decreased), and higher H-FABP (levels (340 ± 115 ng/ml vs. 10.3 ± 0.2 ng/ml; all THS vs. shams, P < 0.001) at 180 min post-THS injury. Histopathological and flow-cytometry analysis of the heart confirmed an influx of circulatory leukocytes, compared to non-injured hearts. Myocardial injury was supported by an increase of troponin I and h-FABP and the widespread ultrastructural disorganization of the morphology of sarcomeres and mitochondria. DNA fragmentation and chromatin condensation driven by leakage of apoptosis-inducing factor (AIF) may suggest a mitochondria-driven progressive cell death. THS modeling in the mouse results in cardiomyocyte damage and reduced myocardial function, which mimics the cardiac dysfunction seen in trauma patients. This CD model may, therefore, provide further understanding to the mechanisms underlying CD and act as a tool for developing cardioprotective therapeutics to improve survival after injury.
Using Interval Analysis to Compute the Invariant Set of a Nonlinear Closed-Loop Control System
Authors: Romig Swantje , Jaulin Luc , Rauh Andreas
Published: December 2019

In recent years, many applications, as well as theoretical properties of interval analysis have been investigated. Without any claim for completeness, such applications and methodologies range from enclosing the effect of round-off errors in highly accurate numerical computations over simulating guaranteed enclosures of all reachable states of a dynamic system model with bounded uncertainty in parameters and initial conditions, to the solution of global optimization tasks. By exploiting the fundamental enclosure properties of interval analysis, this paper aims at computing invariant sets of nonlinear closed-loop control systems. For that purpose, Lyapunov-like functions and interval analysis are combined in a novel manner. To demonstrate the proposed techniques for enclosing invariant sets, the systems examined in this paper are controlled via sliding mode techniques with subsequently enclosing the invariant sets by an interval based set inversion technique. The applied methods for the control synthesis make use of a suitably chosen Gröbner basis, which is employed to solve Bézout’s identity. Illustrating simulation results conclude this paper to visualize the novel combination of sliding mode control with an interval based computation of invariant sets.
Are Older Patients with Cervical Cancer Managed Differently to Younger Patients? An International Survey
Authors: Frelaut Maxime , De Glas Nienke , Zapardiel Ignacio , Kaidar-Person Orit , Kfoury Maria , You Benoit , Banerjee Susana , Brain Etienne , Falandry Claire , Rodrigues Manuel
Published: December 2019

Although a quarter of cervical cancers occur after the age of 65 years, there is no treatment consensus for these patients. The aim of this work was to survey how physicians treat patients with advanced cervical cancer, focusing on treatment adjustments according to age and frailty status. Specialists were invited to an online survey. Data collected included information on respondent and treatment strategy in four cases (FIGO IIb, FIGO IVa, FIGO IVb, metastatic recurrence) with three age scenarios (45-year-old, 75-year-old and fit, 75-year-old and unfit). We received 237 responses of which 117 were fully completed. Thirty-four percent of respondents reported they had available access to a geriatric team and 25% used a frailty screening tool in routine. Therapeutic strategies did not differ between young and old fit patients. However, treatment modalities and intensity were different for old and unfit patients. Physicians answered that they would treat old fit patients as their younger counterparts but would reduce treatment intensity for old unfit patients. However, even if they were willing to adapt their treatment strategy based on frailty status, most of them do not use the tools that would allow distinguishing “fit” and “unfit” older patients, leaving room for improving accurate geriatric evaluation.
Multifunctional Magnetic Nanowires: Design, Fabrication, and Future Prospects as Cancer Therapeutics
Authors: Nana Abu Bakr A. , Marimuthu Thashree , Kondiah Pierre P. D. , Choonara Yahya E. , Du Toit Lisa C. , Pillay Viness
Published: December 2019

Traditional cancer therapeutics are limited by factors such as multi-drug resistance and a plethora of adverse effect. These limitations need to be overcome for the progression of cancer treatment. In order to overcome these limitations, multifunctional nanosystems have recently been introduced into the market. The employment of multifunctional nanosystems provide for the enhancement of treatment efficacy and therapeutic effect as well as a decrease in drug toxicity. However, in addition to these effects, magnetic nanowires bring specific advantages over traditional nanoparticles in multifunctional systems in terms of the formulation and application into a therapeutic system. The most significant of which is its larger surface area, larger net magnetic moment compared to nanoparticles, and interaction under a magnetic field. This results in magnetic nanowires producing a greater drug delivery and therapeutic platform with specific regard to magnetic drug targeting, magnetic hyperthermia, and magnetic actuation. This, in turn, increases the potential of magnetic nanowires for decreasing adverse effects and improving patient therapeutic outcomes. This review focuses on the design, fabrication, and future potential of multifunctional magnetic nanowire systems with the emphasis on improving patient chemotherapeutic outcomes.
ALDH3A1 Overexpression in Melanoma and Lung Tumors Drives Cancer Stem Cell Expansion, Impairing Immune Surveillance through Enhanced PD-L1 Output
Authors: Terzuoli Erika , Bellan Cristiana , Aversa Sara , Ciccone Valerio , Morbidelli Lucia , Giachetti Antonio , Donnini Sandra , Ziche Marina
Published: December 2019

Melanoma and non-small-cell lung carcinoma (NSCLC) cell lines are characterized by an intrinsic population of cancer stem-like cells (CSC), and high expression of detoxifying isozymes, the aldehyde dehydrogenases (ALDHs), regulating the redox state. In this study, using melanoma and NSCLC cells, we demonstrate that ALDH3A1 isozyme overexpression and activity is closely associated with a highly aggressive mesenchymal and immunosuppressive profile. The contribution of ALDH3A1 to the stemness and immunogenic status of melanoma and NSCLC cells was evaluated by their ability to grow in 3D forming tumorspheres, and by the expression of markers for stemness, epithelial to mesenchymal transition (EMT), and inflammation. Furthermore, in specimens from melanoma and NSCLC patients, we investigated the expression of ALDH3A1, PD-L1, and cyclooxygenase-2 (COX-2) by immunohistochemistry. We show that cells engineered to overexpress the ALDH3A1 enzyme enriched the CSCs population in melanoma and NSCLC cultures, changing their transcriptome. In fact, we found increased expression of EMT markers, such as vimentin, fibronectin, and Zeb1, and of pro-inflammatory and immunosuppressive mediators, such as NFkB, prostaglandin E2, and interleukin-6 and -13. ALDH3A1 overexpression enhanced PD-L1 output in tumor cells and resulted in reduced proliferation of peripheral blood mononuclear cells when co-cultured with tumor cells. Furthermore, in tumor specimens from melanoma and NSCLC patients, ALDH3A1 expression was invariably correlated with PD-L1 and the pro-inflammatory marker COX-2. These findings link ALDH3A1 expression to tumor stemness, EMT and PD-L1 expression, and suggest that aldehyde detoxification is a redox metabolic pathway that tunes the immunological output of tumors.
Effects of Substitution Pattern in Phosphite Ligands Used in Rhodium-Catalyzed Hydroformylation on Reactivity and Hydrolysis Stability
Authors: Kloß Svenja , Selent Detlef , Spannenberg Anke , Franke Robert , Börner Armin , Sharif Muhammad
Published: December 2019

The stability of homogeneous catalytic systems is an industrially crucial topic, which, however, receives comparatively little attention from academic research. Phosphites are among the most frequently used ligands in industrial, rhodium-catalyzed n-regioselective hydroformylation. However, they are particularly vulnerable to hydrolysis. Since the decomposition of ligands should be dependent on the substitution patterns, phenyl, tert-butyl and condensed ring systems of benzopinacolphosphites were evaluated concerning their activity, regioselectivity and hydrolysis stability. A series of twelve strongly related phosphites were synthesized, tested in the hydroformylation of isomeric n-octenes, and studied in hydrolysis experiments using in situ NMR spectroscopy. Our results show that substituents in the ortho-position, especially tert-butyl substituents, enhance hydrolysis stability while maintaining compelling activity and regioselectivity. In contrast, substituents in the para-position may destabilize the phosphite.
Interleukin-22 Induces the Infiltration of Visceral Fat Tissue by a Discrete Subset of Duffy Antigen Receptor for Chemokine-Positive M2-Like Macrophages in Response to a High Fat Diet
Authors: Kim Eun-Young , Noh Hye Mi , Choi Bongkun , Park Ji-Eun , Kim Ji-Eun , Jang Youngsaeng , Lee Hyung Keun , Chang Eun-Ju
Published: December 2019

Interleukin-22 (IL-22) is a cytokine with important functions in host defense and inflammatory responses and has recently been suggested to play a role in immune-inflammatory system in the context of obesity and its metabolic consequences. The specific cellular targets and mechanisms of IL-22-mediated obesity are largely unknown however. We here identified a previously unknown subset of monocyte-derived Duffy antigen receptors for chemokines (DARC)+ macrophages in epididymal fat adipose tissue and found that they are preferentially recruited into the crown-like structures of adipose tissue in the mouse upon high fat diet-induced obesity. Importantly, DARC+ macrophages highly express the IL-22 receptor (IL-22Ra1). Exposure to recombinant IL-22 shifts macrophages to an alternative M2 polarization pathway and augments DARC expression via a STAT5b signaling axis. STAT5b directly binds to the DARC promoter and a STAT5 inhibitor abrogates the IL-22-mediated induction of DARC. These M2-like DARC+ subpopulations of monocytes/macrophages were elevated in obese db/db mice compared to WT lean mice. Furthermore, subsets of CD14+ and/or CD16+ monocytes/macrophages within human peripheral blood mononuclear cell populations express DARC and the prevalence of these subsets is enhanced by IL-22 stimuli. This suggested that IL-22 is a critical cytokine that promotes the infiltration of adipose tissue macrophages, that regulate inflammatory processes. Taken together, our present findings provide important insights into the molecular mechanism by which IL-22 signal modulates DARC expression in M2-like macrophages.
Hydrogen Peroxide Sensors for Biomedical Applications
Authors: Meier Jakob , M Hofferber Eric , A Stapleton Joseph , M Iverson Nicole
Published: December 2019

Hydrogen peroxide (H2O2) is an important molecule within the human body, but many of its roles in physiology and pathophysiology are not well understood. To better understand the importance of H2O2 in biological systems, it is essential that researchers are able to quantify this reactive species in various settings, including in vitro, ex vivo and in vivo systems. This review covers a broad range of H2O2 sensors that have been used in biological systems, highlighting advancements that have taken place since 2015.
Effect of Powder Mixture Composition on the Deposition Efficiency in Cold Spay: Modelling and Experimental Validation
Authors: Lapushkina E. , Sova A.
Published: December 2019

In this paper, a new semiempirical probability model, allowing for prediction of the composition of multimaterial cold spray coating in dependence on the initial percentage of blend components, is developed and applied. The proposed modeling approach takes into account the deposition efficiencies and the particle sizes of each component of the spraying powder blend. The experimental validation using several Cu/Cr2C3NiCr mixtures with different percentages of copper and cermet powders showed that the simulation results were in a good agreement with the experimental data. It was demonstrated that the deposition efficiency of the Cr2C3NiCr cermet powder strongly decreased when its mass percentage in the Cu/Cr2C3NiCr mixture increased from 5% to 75%. It was also shown that the dependence of the Cr2C3NiCr content in the coating on the initial percentage in the blend was nonlinear and the standard rule of mixtures was not applicable for prediction of copper–cermet coating composition.
Utilising the Social Return on Investment (SROI) Framework to Gauge Social Value in the Fast Forward Program
Authors: Ravulo Jioji , Said Shannon , Micsko Jim , Purchase Gayl
Published: December 2019

A market paradigm shift towards a ‘knowledge-based economy’ means Australia is moving towards a major skills crisis whereby the workface will lack skills attainable from higher education. Moreover, those from low socio-economic backgrounds, and who are confronted with disadvantage, still face challenges in gaining entry to university. The Fast Forward Program (FFP) aims to increase attainment of higher education for X high school students in years 9–12, with a focus on dismantling the social barriers preventing attainment. To achieve this aim, the program hosts a range of student and parent in-school workshops and on-campus visits. To capture the social impact of the program for all participants, the social return on investment (SROI) methodology was implemented. The SROI ratio is represented as a return in dollar value for every dollar invested; due to the success of the program, the investment represented $5.73 for every $1 spent. The key findings indicated that students and parents gained a deeper familiarity and understanding of university which, in turn, created a deeper confidence and motivation for students to enter higher education. Additionally, participants reported being able to better use their time to cater for study, and were more comfortable about going onto a university campus.
Soil Type, Topography, and Land Use Interact to Control the Response of Soil Respiration to Climate Variation
Authors: Wang Chun , Lai Xiaoming , Zhu Qing , Castellano Michael J. , Yang Guishan
Published: December 2019

The effects of soil and topography on the responses of soil respiration (Rs) to climatic variables must be investigated in the southeastern mountainous areas of China due to the rapid land-use change from forest to agriculture. In this study, we investigated the response of Rs to soil temperature (ST), precipitation over the previous seven days (AP7), and soil water content (SWC) across two hillslopes that had different land uses: a tea garden (TG) and a bamboo forest (BF). Meanwhile, the roles of soil properties including soil clay content and total nitrogen (TN), and topography including elevation, profile curvature (PRC), and slope on the different responses of Rs to these climatic variables were investigated. Results showed that mean Rs on the BF hillslope (2.21 umol C m−2 s−1) was 1.71 times of that on the TG hillslope (1.29 umol C m−2 s−1). Soil clay content, elevation, and PRC had negative correlations (p < 0.05) with spatial variation of Rs, and ST was positively correlated (p < 0.01) with temporal variation of Rs on both hillslopes. Across both hillslopes ST explained 33%–73% and AP7 explained 24%–38% of the temporal variations in Rs. The mean temperature sensitivities (Q10s) of Rs were 2.02 and 3.22, respectively, on the TG and BF hillslopes. The Q10 was positively correlated (p < 0.05) with the temporal mean of SWC and TN, and negatively correlated (p < 0.05) with clay and slope. The mean AP7 sensitivities (a concept similar to Q10) were greatly affected by clay and PRC. When Rs was normalized to that at 10 °C, power or quadratic relationships between Rs and SWC were observed in different sites, and the SWC explained 12%–32% of the temporal variation in Rs. When ST and SWC were integrated and considered, improved explanations (45%–81%) were achieved for the Rs temporal variation. In addition, clay and elevation had vital influences on the responses of Rs to SWC. These results highlight the influences of soil, topographic features, and land use on the spatial variations of the Rs, as well as on the responses of Rs to different climatic variables, which will supplement the understanding of controlling mechanisms of Rs on tea and bamboo land-use types in Southeastern China.
An Efficient Dynamic Load Balancing Scheme Based on Nash Bargaining in SDN
Authors: Li Guoyan , Li Kaixin , Liu Yi , Pan Yuheng
Published: December 2019

Static multi-controller deployment architecture cannot adapt to the drastic changes of network traffic, which will lead to a load imbalance between controllers, resulting in a high packet loss rate, high latency, and other network performance degradation problems. In this paper, an efficient dynamic load balancing scheme based on Nash bargaining is proposed for a distributed software-defined network. Firstly, considering the connectivity of network nodes, the switch migration problem is transformed into a network mapping relationship reconstruction problem. Then, we establish the Nash bargaining game model to fairly optimize the two contradictory goals of migration cost and load balance. Finally, the model is solved by an improved firefly algorithm, and the optimal network mapping state is obtained. The experimental results show that this scheme can optimize the migration cost and load balance at the same time. Compared with the existing research schemes, the migration process of the switch is optimized, and, while effectively balancing the load of the control plane, the migration cost is reduced by 14.5%.
A Political Action against the Good Immigrant Narrative
Authors: Campos Ramales Liliana
Published: December 2019

This brief article draws from research on the undocumented student experience and incorporates personal perspectives about the complexity behind the good immigrant-model, minority narrative on identity formation. From a de-colonial lens, this article aims to emphasize the impact of the DREAM(Development, Relief and Education for Alien Minors)-er narrative on the immigrants right’s movement and urges a need to separate the narrative from the movement as a political action to continue to diversify immigration reform advocacy as more inclusive of various immigrant and undocumented sub-communities. Lastly, this article aims to challenge the sociopolitical construct of the undocumented term on identity and introduces the importance of person-centered language to externalize undocumented legal status from the individual to position it as a circumstance rather than an identity.
Weighted Genomic Best Linear Unbiased Prediction for Carcass Traits in Hanwoo Cattle
Authors: Lopez Bryan Irvine , Lee Seung-Hwan , Park Jong-Eun , Shin Dong-Hyun , Oh Jae-Don , de las Heras-Saldana Sara , van der Werf Julius , Chai Han-Ha , Park Woncheoul , Lim Dajeong
Published: December 2019

The genomic best linear unbiased prediction (GBLUP) method has been widely used in routine genomic evaluation as it assumes a common variance for all single nucleotide polymorphism (SNP). However, this is unlikely in the case of traits influenced by major SNP. Hence, the present study aimed to improve the accuracy of GBLUP by using the weighted GBLUP (WGBLUP), which gives more weight to important markers for various carcass traits of Hanwoo cattle, such as backfat thickness (BFT), carcass weight (CWT), eye muscle area (EMA), and marbling score (MS). Linear and different nonlinearA SNP weighting procedures under WGBLUP were evaluated and compared with unweighted GBLUP and traditional pedigree-based methods (PBLUP). WGBLUP methods were assessed over ten iterations. Phenotypic data from 10,215 animals from different commercial herds that were slaughtered at approximately 30-month-old of age were used. All these animals were genotyped using Illumina Bovine 50k SNP chip and were divided into a training and a validation population by birth date on 1 November 2015. Genomic prediction accuracies obtained in the nonlinearA weighting methods were higher than those of the linear weighting for all traits. Moreover, unlike with linear methods, no sudden drops in the accuracy were noted after the peak was reached in nonlinearA methods. The average accuracies using PBLUP were 0.37, 0.49, 0.40, and 0.37, and 0.62, 0.74, 0.67, and 0.65 using GBLUP for BFT, CWT, EMA, and MS, respectively. Moreover, these accuracies of genomic prediction were further increased to 4.84% and 2.70% for BFT and CWT, respectively by using the nonlinearA method under the WGBLUP model. For EMA and MS, WGBLUP was as accurate as GBLUP. Our results indicate that the WGBLUP using a nonlinearA weighting method provides improved predictions for CWT and BFT, suggesting that the ability of WGBLUP over the other models by weighting selected SNPs appears to be trait-dependent.
School-Related Risk Factors of Internet Use Disorders
Authors: Kindt Sophie , Szász-Janocha Carolin , Rehbein Florian , Lindenberg Katajun
Published: December 2019

A growing body of research focusing on the risk factors of Internet use disorder (IUD) underlines the effect of sociodemographic variables like age and gender or comorbid mental disorders on IUD symptoms. The relation between IUD symptoms and school-related variables has to date been insufficiently studied. The present study closes this gap by investigating the relation between school-relevant factors such as absenteeism, school grades, procrastination, school-related social behavior, and learning behavior and IUD symptoms in a high-risk sample. n = 418 students between 11 and 21 years of age (M = 15.10, SD = 1.97), screened for elevated risk of IUD, participated in the study. Sociodemographic data, school grades and absent days, Internet use variables (time spent online and gaming), as well as school-related psychological variables (procrastination, learning behavior, and social behavior) were assessed via self-report questionnaires. IUD symptoms were assessed with an adapted version of the German Video Game Dependency Scale (CSAS), which is based on the 9 criteria for Internet gaming disorder in the DSM-5. The instrument was adapted to include the assessment of non-gaming IUD symptoms. Taking the hierarchical structure of the data into account, a multilevel modeling approach was used to analyze the data. Procrastination, time spent online, and gaming were significant predictors of IUD symptoms at the individual level, whereas social behavior significantly predicted symptoms of IUD at the school level. In addition to previous findings on risk factors of IUD, this study indicates the importance of school-related factors in the development of IUD, especially psychological factors that play a role in the school setting. The early age of IUD onset and the high relevance of prevention of IUD at the school age underline the relevance of this finding.
Restorative Effects of Multi-Sensory Perception in Urban Green Space: A Case Study of Urban Park in Guangzhou, China
Authors: Zhang Tianyao , Liu Jiahui , Li Hongyang
Published: December 2019

Urban green space is believed as a beneficial landscape for mental restoration in the urban settings. This study aims to examine the restorative quality of the urban green space from a multi-sensory perspective, focusing on both direct and indirect connections between visual, auditory, and tactile sensations and mental restoration. Two hundred and fifty park users of Tianhe Park in Guangzhou, China, were surveyed. Data were collected regarding their three types of sensations, i.e., the perceived mental restoration, health-related behavioral activities and emotional responses in the urban park. As a result, visual and auditory sensation were found to be linked with mental restoration directly and indirectly, while the tactile sensation was only associated with mental restoration indirectly; and health-related behaviors and emotional response mediated the relations between the three sensations and mental restoration significantly. It is concluded that the greater effects of auditory sensation and the under-studied potential effects of tactile sensation on mental restoration should be more emphasized in the future design of urban park. This is expected to contribute to the high restorative quality of the urban green space and promote public health.
Toward an Expanded Focus for Occupational Safety and Health: A Commentary
Authors: Schulte Paul A. , Delclos George , Felknor Sarah A. , Chosewood L. Casey
Published: December 2019

Powerful and ongoing changes in how people work, the workforce, and the workplace require a more holistic view of each of these. We argue that an expanded focus for occupational safety and health (OSH) is necessary to prepare for and respond rapidly to future changes in the world of work that will certainly challenge traditional OSH systems. The WHO Model for Action, various European efforts at well-being, and the Total Worker Health concept provide a foundation for addressing changes in the world of work. However, a paradigm expansion to include the recognition of worker and workforce well-being as an important outcome of OSH will be needed. It will also be vital to stimulate transdisciplinary efforts and find innovative ways to attract and train students into OSH professions as the paradigm expands. This will require active marketing of the OSH field as vibrant career choice, as a profession filled with meaningful, engaging responsibilities, and as a well-placed investment for industry and society. An expanded paradigm will result in the need for new disciplines and specialties in OSH, which may be useful in new market efforts to attract new professionals. Ultimately, to achieve worker and workforce well-being we must consider how to implement this expanded focus.
The Physical Activity Questionnaire for the Elderly (PAQE): A Polish Adaptation
Authors: Król-Zielińska Magdalena , Ciekot-Sołtysiak Monika , Osiński Wiesław , Kantanista Adam , Zieliński Jacek , Szeklicki Robert
Published: December 2019

The aim of the study is to assess the reliability and validity of the Polish adaptation of the Physical Activity Questionnaire for the Elderly (PAQE-PL). One hundred and four older adults (75 women and 29 men) aged 65 to 89 (mean 72.2 ± 5.7 years) participated in the study. The test–retest procedure was used to evaluate the reliability of the PAQE-PL. Validity was assessed by comparing the results of the PAQE-PL with the measurements from an accelerometer (ActiGraph wGT3X+) and two questionnaires: the Polish version of the Community Healthy Activities Model Program for Seniors (CHAMPS-PL) and the Polish version of the Yale Physical Activity Survey (YPAS-PL). All test–retest interclass correlation coefficients (ICCs) were significant (ranged from 0.64 to 0.92). The long-term stability showed significant ICCs (ranged from 0.38 to 0.87) for all participants. In regard to validity, the obtained correlation coefficients were relatively low but statistically significant for all participants between the PAQE-PL scores and energy expenditure (r ranging from 0.25 to 0.26) measured by the accelerometer. The PAQE-PL correlated with almost all CHAMPS-PL indices, YPAS-PL energy expenditure, and total physical activity time. The results suggest that the adaptation of the PAQE-PL is an acceptable tool to estimate the physical activity level among older adults in the Polish population. We recommend the cautious and well-thought-out use of the PAQE-PL with a population of older women.
Influence of Health Literacy on the Physical Activity of Working Adults: A Cross-Sectional Analysis of the TRISEARCH Trial
Authors: Rudolf Kevin , Biallas Bianca , Dejonghe Lea A. L. , Grieben Christopher , Rückel Lisa-Marie , Schaller Andrea , Stassen Gerrit , Pfaff Holger , Froböse Ingo
Published: December 2019

Studies show that high health literacy (HL) can support the promotion and maintenance of healthy behavior such as physical activity (PA). However, most studies rely on subjective data. The aim of the present study is to investigate the relationship between HL and PA, not only with subjectively but also with objectively measured PA data. The present study is a pooled analysis of baseline data from the research association TRISEARCH (2015–2018), which focused on the HL of working adults. HL was measured by Lenartz’ questionnaire, and PA by the Global Physical Activity Questionnaire (GPAQ; n = 1056). A subsample (n = 124) also received accelerometers (Actigraph GT3X+) to provide more objective PA data. Partial correlations and regression models were used to investigate the relationship between HL and questionnaire- and accelerometer-derived PA. Very low and medium partial correlations could be found for HL subscales and daily PA by questionnaire (r = −0.06, p < 0.05) and accelerometer (r = 0.26, p < 0.01). No subscale of HL made a significant contribution to the amount of daily PA (all p > 0.05). Not all subscales of HL seem to have an influence on the occurrence of healthy behavior, such as PA. This should be considered when HL-based interventions are designed. Further investigation of the relationship between HL and PA is needed. Objective assessments of both HL and PA can provide additional information for this task.
Revenge among Parents Who Have Broken up Their Relationship through Family Law Courts: Its Dimensions and Measurement Proposal
Authors: Clemente Miguel , Padilla-Racero Dolores , Espinosa Pablo
Published: December 2019

This work analyzes inter-parental revenge after a breakup process, as it relates to the dark triad of personality, moral disengagement, and sex role ideology. Our objective was to test a predictive model for revenge based on these variables. Additionally, a scale to measure revenge among parents was developed. A sample of 384 participants who had minor children, had broken up their relationship, and had undergone or were undergoing problematic judicial procedures regarding their children completed a survey. They answered to measures of the dark triad of personality (Machiavellianism, narcissism, psychopathy); moral disengagement strategies; sex role ideology, and revenge. An instrument (the R scale), with adequate reliability and validity was developed to test revenge. Results show that revenge behaviors are perpetrated by 1 to 5% of participants. Revenge has three components: revenge through the child, revenge through economic manipulation, and revenge by cutting off communication. Results also show that for males, but not for females, sex role ideology mediates the relationship between the components of the dark triad, moral disengagement, and revenge. This paper aims at providing some insight for the protection of minors from manipulation by means of the Family Courts.
Implications of Cardioprotective Assumptions for National Drinking Guidelines and Alcohol Harm Monitoring Systems
Authors: Sherk Adam , Gilmore William , Churchill Samuel , Lensvelt Eveline , Stockwell Tim , Chikritzhs Tanya
Published: December 2019

The existence and potential level of cardioprotection from alcohol use is contested in alcohol studies. Assumptions regarding the risk relationship between alcohol use and ischaemic heart disease (IHD) are critical when providing advice for national drinking guidelines and for designing alcohol harm monitoring systems. We use three meta-analyses regarding alcohol use and IHD risk to investigate how varying assumptions lead to differential estimates of alcohol-attributable (AA) deaths and weighted relative risk (RR) functions, in Australia and Canada. Alcohol exposure and mortality data were acquired from administrative sources and AA fractions were calculated using the International Model of Alcohol Harms and Policies. We then customized a recent Global Burden of Disease (GBD) analysis to inform drinking guidelines internationally. Australians drink slightly more than Canadians, per person, but are also more likely to identify as lifetime abstainers. Cardioprotective scenarios resulted in substantial differences in estimates of net AA deaths in Australia (between 2933 and 4570) and Canada (between 5179 and 8024), using GBD risk functions for all other alcohol-related conditions. Country-specific weighted RR functions were analyzed to provide advice toward drinking guidelines: Minimum risk was achieved at or below alcohol use levels of 10 g/day ethanol, depending on scenario. Consumption levels resulting in ‘no added’ risk from drinking were found to be between 10 and 15 g/day, by country, gender, and scenario. These recommendations are lower than current guidelines in Australia, Canada, and some other high-income countries: These guidelines may be in need of downward revision.
Changes in Physical Activity Behaviour and Psychosocial Correlates Unique to the Transition from Primary to Secondary Schooling in Adolescent Females: A Longitudinal Cohort Study
Authors: Ridley Kate , Dollman James
Published: December 2019

Few studies have investigated physical activity changes over the transition from primary to secondary school. This study assessed change in physical activity and the psychosocial correlates across 12 months in two cohorts of adolescent girls, who were either in primary school in year 1, moving to secondary school in year 2 (Transition cohort) or an older cohort (Secondary cohort) who remained in early secondary school. Female adolescents (n = 191; 38% response rate) in South Australia self-reported physical activity and psychosocial correlates of physical activity. Changes between baseline and 12-month follow-up were assessed using paired t-tests. Multiple regression modelling identified psychosocial predictors of physical activity change. Physical activity declined in the transition but not the secondary cohort. The decline was most pronounced during school break times. Independent predictors of physical activity change were: change in enjoyment in the transition cohort; and changes in enjoyment, perceived outcomes, and friend encouragement in the secondary cohort. Transitioning from primary to secondary school is a critical period during which physical activity typically declines, particularly among females. Effective physical activity promotion in this vulnerable group will depend on a deeper understanding of the sociocultural, curricular and environmental influences on physical activity that are unique to each school context.
Chocolate, “Food of the Gods”: History, Science, and Human Health
Authors: Montagna Maria Teresa , Diella Giusy , Triggiano Francesco , Caponio Giusy Rita , Giglio Osvalda De , Caggiano Giuseppina , Ciaula Agostino Di , Portincasa Piero
Published: December 2019

Chocolate is well known for its fine flavor, and its history began in ancient times, when the Maya considered chocolate (a cocoa drink prepared with hot water) the “Food of the Gods”. The food industry produces many different types of chocolate: in recent years, dark chocolate, in particular, has gained great popularity. Interest in chocolate has grown, owing to its physiological and potential health effects, such as regulation of blood pressure, insulin levels, vascular functions, oxidation processes, prebiotic effects, glucose homeostasis, and lipid metabolism. However, further translational and epidemiologic studies are needed to confirm available results and to evaluate other possible effects related to the consumption of cocoa and chocolate, verifying in humans the effects hitherto demonstrated only in vitro, and suggesting how best to consume (in terms of dose, mode, and time) chocolate in the daily diet.
The Mediating Effect of Sleep Quality on the Relationship between Emotional and Behavioral Problems and Suicidal Ideation
Authors: Xiao Luyao , Zhang Sheng , Li Wenyan , Wu Ruipeng , Wang Wanxin , Wang Tian , Guo Lan , Lu Ciyong
Published: December 2019

Emotional and behavioral problems in adolescents are associated with suicidal ideation, but different dimensions of problems may be associated with different levels of suicidal ideation. The aim of this large-scale study was to explore the relationship between different dimensions of emotional and behavioral problems and suicidal ideation in Chinese adolescents and to determine whether sleep disorders play a mediating role in the relationship. In total, 20,475 students completed the questionnaire regarding emotional and behavioral problems, sleep quality and suicidal ideation. After adjustment for covariates, total emotional and behavioral difficulties (adjusted odds ratios (AOR) = 1.22, 95% confidence interval (CI) = 1.21–1.23) and sleep disorders (AOR = 4.17, 95% CI = 3.82–4.54) increased the risk of suicidal ideation, while prosocial problems (AOR = 0.91, 95% CI = 0.90–0.93) decreased the risk of suicidal ideation. Sleep quality partially mediated the relationship between emotional and behavioral problems and suicidal ideation. The standardized indirect effects of emotional and behavioral difficulties on suicidal ideation (standardized β estimate = 0.031, 95% CI = 0.020, 0.044) and the effects of prosocial problems on suicidal ideation (standardized β estimate = −0.039, 95% CI = −0.045, −0.035) mediated by sleep quality were statistically significant (p < 0.001). Our study indicates that emotional and behavioral problems increase the risk of suicidal ideation. Additionally, sleep quality plays a mediating role in the association between emotional and behavioral problems and suicidal ideation.