bluuebunny/crossref_metadata_2025 huggingface dataset:
Bioquímica clínica de las bases teóricas a la práctica
Authors:   Universidad de Cartagena, Moneriz Pretell Carlos , Alvear Sedán Ciro César , Pedroza Bedoya José , Reyes Hernández Melissa
Published: January 2025

Este libro hace parte de la Colección Edgar Parra Chacón, que surge de la Cuarta convocatoria interna para la publicación de libros académicos y/o de creación artística, como parte del plan de convocatorias de la Vicerrectoría de Investigación de la Universidad de Cartagena. El presente libro está escrito y dirigido a estudiantes de pregrado y posgrado que cursan la asignatura Bioquímica, pertenecientes tanto a las ciencias de salud o ciencias biomédicas, como a las ciencias exactas. Actualmente es reconocido el papel y la importancia de la enseñanza de la Bioquímica y de su aplicación clínica en la formación de profesionales de diversas áreas del conocimiento: médicos, biólogos, químicos, farmacéuticos, odontólogos, enfermeros, bacteriólogos, nutricionistas, entre otros, que deben apropiarse comprensivamente de su contenido, para que puedan desarrollar sus competencias con rigor científico en el campo de su desempeño profesional. El libro posee una estructura sistemática en cuatro secciones. Cada una de ellas hace una descripción de las principales técnicas y métodos bioquímicos, los cuales abarcan desde la fundamentación teórica básica de cada técnica de laboratorio hasta los principios metodológicos que la sustentan
The Correlation Between Vocabulary Mastery and Translation Ability to Students of SMA Negeri 4 Pangkalpinang
Authors: Rasuan Zulfikri B , Fauzi Fauzi
Published: January 2025

This research focuses on the correlation between vocabulary mastery and translation ability to students of Senior High School (SMA) 4 Pangkalpinang. This study will be conducted by applying a correlational design. It will be used to measure and describe the relationship between two variables in this study namely Independent and Dependent variables. The Independent variable is students’ vocabulary mastery and the dependent variable is the students’ translation ability of the students of SMAN 4 Pangkalpinang. the population of this study were all of the students of grade XI of SMAN 4 Pangkalpinang in academic year 2021/2022. The finding of the research can be concluded that the vocabulary achievement is fair. It can be seen from the computation in which the mean score of the students’ vocabulary achievement is 63.2 when it is consulted to the table of category level scores by John W. Best (2021:260); the score is categorized in fair. the translation ability is fair. It can be seen from the computation in which the mean score of the students’ translation ability is 70.77 when it is consulted to the table of category level scores by John W. Best (2021:260); the score is categorized in fair. There is a significant positive correlation between the vocabulary mastery and translation ability. There is a significant positive correlation between the vocabulary mastery (X) and translation ability (Y).
Challenging Mental Health Professionals to Look Beyond the Consulting Room
Authors: Searight Russell
Published: January 2025

William Doherty and Tai Mendenhall's work on the "Citizen Therapist" model bridges psychotherapy with social engagement, emphasizing the interplay between mental health and societal factors. Their book critiques hyper-individualism in therapy, advocating for therapists to address systemic issues such as political polarization, racism, and culturally sensitive healthcare. In addition to outlining the rationale and practical guidelines for mental health professionals to collaborate with their fellow citizens, the book provides examples of programs aimed at addressing community conflicts, promoting healthy lifestyles, and enhancing family life. The model emphasizes community-driven solutions while maintaining professional boundaries, highlighting the connection between individual well-being and societal health.
Stresna osjetljivost svinja - stanje i trendovi
Authors: Škorput Dubravko , Delić Petra , Kaić Ana , Luković Zoran , Karolyi Danijel
Published: January 2025

Genetski uvjetovana stresna osjetljivost svinja jedan je od najpoznatijih problema koji se javlja u proizvodnji i preradi svinjskog mesa. Imajući u vidu ekonomsku važnost proizvodnje svinjskog mesa ova se pojava nastoji izbjeći budući da može povećati mortalitet u završnoj fazi proizvodnje uslijed razvoja maligne hipertermije te uzrokovati probleme za mesnu industriju zbog loše kvalitete svinjskog mesa koje je manje pogodno za tržište ili preradu zbog nepovoljnih fizikalno-kemijskih karakteristika. Cilj ovog rada bio je prikazati mehanizam nastanka sindroma maligne hipertermije kod stresno osjetljivih svinja, čimbenike koji pridonose ovoj pojavi, opisati pasmine svinja koje su podložne stresnoj osjetljivosti, definirati utjecaj stresne osjetljivosti na svojstva i kakvoću mesa, te mjere za prevenciju kako bi proizvodnja svinjskog mesa bila što ekonomičnija i bez navedenih gubitaka. Uz genetske analize i selekciju protiv mutiranog ryanodin receptor-1 gena (RYR1), stres kod svinja nastoji se izbjeći strožim zakonima vezanima za dobrobit životinja usmjerenim na pravilno postupanje sa životinjama. Osiguranjem adekvatnog prijevoza, mikroklimatskih uvjeta na farmama i prijevoznim sredstvima, te blažim postupcima neposredno pred klanje i pravilnim omamljivanjem može se smanjiti stres kod svinja, a pri tome izbjeći negativne promjene na mesu. Trenutno stanje glede stresne osjetljivosti svinja u Republici Hrvatskoj je zadovoljavajuće, s obzirom da laboratorijskim analizama nije utvrđena prisutnost recesivnih homozigota, uz mali broj heterozigota za gen odgovoran za pojavu stresne osjetljivosti.
Biomarcadores en el diagnóstico temprano de las enfermedades neurodegenerativas
Authors: Castro Jácome Deisy Nataly , Yauli Flores Carlos Fernando
Published: January 2025

Introducción. las enfermedades neurodegenerativas hacen referencia a un conjunto heterogéneo de trastornos cuyo inicio es desconocido y que afectan de forma progresiva a la degeneración de circuitos neuronales, como consecuencia una pérdida progresiva de funciones como la memoria, el movimiento y el habla. El Alzheimer, el Parkinson, Esclerosis Lateral Amiotrófica y Huntington son ejemplos comunes de estas enfermedades. El Alzheimer es causada por la acumulación de beta amiloide dando lugar a la formación de placas que dañan las neuronas, Parkinson se da una degeneración progresiva de las neuronas en una región específica del cerebro llamada sustancia negra. Esclerosis Lateral Amiotrófica caracterizada por la degeneración selectiva de las neuronas motoras, lo que conduce a debilidad muscular y Huntington afecta principalmente a una región del cerebro llamada estriado. Objetivos: investigar y evaluar el impacto y la eficacia de los biomarcadores en el diagnóstico temprano de las enfermedades neurodegenerativas. Metodología: Para la redacción se basó en una metodología rigurosa en la revisión bibliográfica, en la que se priorice la transparencia en la presentación de la información. Todas las fuentes consultadas fueron debidamente citadas y referenciadas, dando seguridad de la trazabilidad de los datos y la posibilidad de verificar la información. Resultados: los biomarcadores en la detección temprana de enfermedades neurodegenerativas permiten detectar alteraciones antes de que aparezcan los síntomas clínicos, de tal modo que facilite la elección de tratamientos efectivos, el seguimiento de la enfermedad y la personalización de las terapias. El presente artículo revisa de manera exhaustiva información actualizada sobre los distintos tipos de biomarcadores de las patologías neurodegenerativas para poder brindar una nueva panorámica acerca de las mismas. Conclusiones: Los biomarcadores en su rol actual y futuro se considera una herramienta importante para la detección temprana de enfermedades neurodegenerativas como el Alzheimer, Parkinson, Esclerosis Lateral Amiotrófica y Huntington, debido a que permite identificar proteínas anormales específicas de cada patología en fluidos como el líquido cefalorraquídeo, sangre o tejidos, otorgando un mayor grado de especificidad que contribuye de forma significativa en la calidad de vida de los pacientes. Área de estudio general: Ciencias de la Salud. Área de estudio específica: Laboratorio clínico. Tipo de estudio: Revisión Bibliográfica.
Edukasi Peningkatan Kesadaran Masyarakat Dalam Menjaga Primitive Horseshoe Crab (Belangkas) Sebagai Biota Yang Dilindungi Di Desa Sungsang, Kabupaten Banyuasin, Sumatera Selatan
Authors: Fauziyah Fauziyah , Ningsih Ellis Nurjuliasti , Agustriani Fitri , Nur Muhamad , Melki Melki , Rozirwan Rozirwan , Febrianti Amanda Astri Pratiwi
Published: January 2025

Penangkapan ikan di perairan Banyuasin seperti belangkas (horseshoe crab) menimbulkan kekhawatiran terhadap kelestarian spesies ini. Oleh karena itu, diperlukan upaya untuk meningkatkan kesadaran untuk menjaga biota laut yang dilindungi dan melestarikan lingkungan. Kegiatan pengabdian ini bertujuan untuk meningkatkan kesadaran masyarakat untuk menjaga biota laut yang dilindungi dari ancaman kepunahan di wilayahnya dan lebih menghargai lingkungan serta saling berbagi pengalaman di antara mereka. Metode yang dilakukan adalah wawancara dan memberikan edukasi. Instrumen yang digunakan sebagai alat ukur keberhasilan kegiatan adalah Pre dan post-test serta umpan balik. Kegiatan pengabdian ini dilaksanakan pada bulan September 2023 di Desa Sungsang, Kabupaten Banyuasin, Sumatera Selatan. Hasil pengabdian adalah terjadi pemahaman yang meningkat dari responden dalam mengenali horseshoe crab (dari 97,8% menjadi 100%) dan mampu membedakan jantan dan betina (semula 38,6% menjadi 80%). Selain itu, kesadaran responden meningkat untuk melepaskan horseshoe crab yang terjaring alat tangkap ke perairan (semula 50,9% menjadi 100%) dan peningkatan kesadaran bahwa horseshoe crab adalah biota yang dilindungi (semula 68,9% menjadi 100%). Mayoritas responden (98,2%) menerima secara positif kegiatan pengabdian ini.
Peningkatan Ekonomi Masyarakat Dengan Memproduksi Produk Olahan Bawang Merah Di Desa Pejok, Kecamatan Kedungadem, Kabupaten Bojonegoro
Authors: Purwanto Gunawan Hadi , Istikomah Istikomah , Lestari Greyana Mia Dwi , Kamila Tarisa Syafa
Published: January 2025

UMKM Desa Pejok yang dikelola oleh ibu-ibu kader PKK merupakan UMKM yang berfokus pada pengolahan bawang merah menjadi produk bawang goreng. UMKM ini menghadapi tantangan dalam pemasaran produk, karena saat ini pemasaran dilakukan secara terbatas, yang mengakibatkan penjualan yang kurang optimal. Penelitian atau Pengapdian kepada Masyarakat ini bertujuan untuk memaksimalkan potensi produk olahan bawang merah sebagai upaya meningkatkan ekonomi masyarakat di Desa Pejok, Kecamatan Kedungadem, Kabupaten Bojonegoro. Kegiatan ini dilakukan melalui metode pelatihan dan pendampingan. Dari pelatihan yang telah dilakukan mengenai pembuatan bawang goreng kepada 55 kader PKK, pemahaman ibu-ibu terhadap proses pembuatan bawang goreng dari bahan baku bawang merah telah meningkat. Melalui pelatihan ini, ibu-ibu kader PKK dapat mengoptimalkan penggunaan bawang merah sebagai bahan utama dalam menghasilkan bawang goreng yang diminati pasar, sehingga menciptakan produk olahan dengan nilai ekonomi yang tinggi. Pendampingan yang dilakukan oleh tim KKN dalam pengelolaan UMKM telah berhasil membawa dampak signifikan terhadap penjualan bawang goreng. Dalam kurun waktu 2 minggu, terjual sebanyak 100 pcs. Peningkatan penjualan ini menunjukkan bahwa strategi pemasaran yang diterapkan, termasuk perubahan pada kemasan, logo, dan desain produk, memberikan hasil positif bagi UMKM.
EFFECTS OF TEMPERATURE AND MOISTURE ON THE RESPONSE OF JOINTED CONCRETE PAVEMENTS
Authors: Rao Chetana , Barenberg Ernest J. , Snyder Mark B. , Schmidt Sarah
Published: January 2025

This paper includes a study of curling and warping in jointed Portland Cement Concrete (PCC) pavements based on the temperature and moisture conditions at the time of paving and immediately following construction. Field data collected from fully instrumented sections at two locations, Phoenix, Arizona and Mankato, Minnesota, were used in this study. These sections were paved at nighttime and daytime respectively. Temperature data were collected through the slab thickness at different times of the day and profile measurements were recorded along the longitudinal edge, transverse edge and the diagonal of the slab. As the data at Mankato were 7th International Conference on Concrete Pavements - Orlando, Florida, USA - September 9-13, 2001 collected for three days immediately following construction and later at the end of 15 days, 40 days and two years, this section provided data suitable for the study of early age and longterm behavior of PCC slabs. On the other hand, the test sections at Arizona with data collected at 3 days and 40 days provided a comparison of the effects of slab length and restraint conditions on the curling and warping of PCC slabs. Material properties determined from lab tests were used in modeling using the Finite Element Method (FEM) program, ISLAB2000. Based on theoretical analysis, an “equivalent temperature gradient” was determined at different ages to account for the combined effects of built-in curl, shrinkage and creep. It was observed that paving during daytime induced high negative gradients that further increased as the pavement underwent drying shrinkage and creep. At the end of two years, as a result of creep in concrete, the pavement appeared to relax its upward curling and warping. Furthermore, the equivalent temperature gradient increased with larger slab length and decreased with the presence of load transfer mechanisms. Finally, it was concluded that in addition to actual temperature gradients, the effects of not only built-in curl but also shrinkage and creep have to be considered in pavement analysis and design.
DYNAMIC ANALYSIS OF RIGID PAVEMENTS WITH DIFFERENT SUBGRADE SUPPORT MODELS
Authors: Chatti Karim , Kim Taekuk
Published: January 2025

It has long been recognized that the accuracy of any slab-on-grade model is strongly dependent on the foundation model used. Therefore, using an accurate structural model for the concrete slab system does not guarantee an accurate response for the slab-subgrade system. Thus, characterizing the subgrade support correctly is essential in order to obtain accurate predictions of the rigid pavement response. Most existing finite-element programs for rigid pavements use the Winkler model as the primary model for subgrade characterization. This paper describes the development of an expanded version of the DYNASLAB computer program with the addition of a frequency-dependent Winkler foundation and a layered foundation model. Using the new DYNASLAB program, several dynamic analyses were conducted to compare results from the two foundation models.
CHARACTERIZATION OF MECHANICAL PROPERTIES AND VARIABILITY OF PCC MATERIALS FOR RIGID PAVEMENT DESIGN
Authors: Mallela Jagannath , Titus-Glover Leslie , Ayers Michael E. , Wilson Thomas P.
Published: January 2025

The FHWA-supervised Long-Term Pavement Performance (LTPP) project includes many experimental Special Pavement Studies (SPS) pavements from which concrete materials were sampled and tested for a variety of concrete mechanical properties. The materials and techniques used in constructing the SPS test pavements represent modern concrete pavement construction practices. The information collected includes compressive strength, flexural strength, split tensile strength, and static elastic modulus. The ages at which the specimens were tested for the various strength parameters ranged from 14 to 500 days. This paper describes an analysis of strength data from the LTPP SPS-2 experiment. The authors studied the rate of strength gain under the varied influences of climate/curing conditions, specimen type, and cement type. The variability of strength data obtained from a given project and the differences between “as-specified” and “as-built” strengths were also investigated. Both strength development and variability are important input parameters for pavement design and reliability analysis. Finally, commonly cited relationships between the various strength parameters were also analyzed. This paper provides typical concrete material inputs to the rigid pavement mechanistic-empirical design process.
Clinical and organizational features of ulcerative colitis and Crohn's disease differential diagnosis: the experience of the specialized City clinic for Inflammatory Bowel Diseases
Authors: Uspenskiy Yu. P. , Ivanov S. V. , Fominykh Yu. A. , Lykova E. A. , Panasyuk A. S. , Dikarev K. V. , Gakhramanova A. A.
Published: January 2025

Introduction. The initial diagnosis of ulcerative colitis and Crohn's disease – inflammatory bowel diseases (IBD) – is quite difficult, requiring a comprehensive evaluation of clinical and anamnesis data, the results of ilecolonoscopy with multifocal biopsy and, results of imaging diagnostic methods (in some cases).

The aim of the study: to estimate the duration of the time period required to establish the IBD diagnosis of and to assess the potential consequences of untimely establishment of this diagnosis.

Materials and methods. The data of 253 patients with ulcerative colitis and 263 patients with Crohn's disease who applied to the city center of St. Petersburg.

Results. In 59 % of ulcerative colitis patients with and in 65 % Crohn's disease patients the diagnosis was established within 3 months from first clinical sighs appearance. Evaluation of the possible association between the duration of the period required to establish the diagnosis of IBD and features of the course of IBD after diagnosis did not reveal a statistically significant association with the rate of recurrence and the risk of developing non-life-threatening complications. When studying the development of life-threatening complications of IBD it was found that only 59 % of such complications occurred after the diagnosis of IBD, while in the remaining cases they occurred either before or caused the diagnosis. Untimely diagnosis of IBD increased the risk of life-threatening complications by 18 times in patients with ulcerative colitis, and by 13 times in patients with Crohn's disease, compared to the situation when the diagnosis was established timely and specific IBD therapy for was initiated.

Conclusion. The majority of IBD patients, who suffered a life-threatening complication before the diagnosis was established, potentially had a temporary «window of opportunity», when on the basis of clinical data it was possible to suspect the presence of IBD, establish the diagnosis with the subsequent timely initiation of specific therapy to prevent a complicated course of the disease.
Antispasmodics in the treatment of abdominal syndrome in IBS and IBS-like syndrome in modern clinical practice
Authors: Osadchuk M. A. , Osadchuk M. M.
Published: January 2025

The presented review evaluates the effectiveness of various antispasmodics in the treatment of abdominal pain in irritable bowel syndrome (IBS) and IBS-like syndrome. Based on the study, it was concluded that the most significant effectiveness of myotropic antispasmodics, and in particular, mebeverin in the treatment of pain syndrome and other clinical manifestations of IBS and IBS-like syndrome and the absence of significant adverse events regardless of the duration of therapy.
La Imagen Aumentada a través de los dispositivos de producción visual
Authors: Infante Barbosa M.ª Ángeles , González Ibáñez Edurne , López Izquierdo M.ª Ángeles
Published: January 2025

Las Imágenes Aumentadas se sustentan en la idea de la imagen especular, puesto que proyectan ambientes y autoimágenes parcialmente alteradas gracias a la identificación de escenarios mediante software de Realidad Aumentada. Se trata de imágenes recicladas y manipuladas, en constante circulación, que exceden la realidad misma y componen una realidad superlativa. A lo largo de la Historia de la humanidad, se ha llevado a cabo el desarrollo de determinadas tecnologías y dispositivos que han facilitado la inclusión de elementos que a simple vista no se ven en el mundo de lo real, permitiendo de esta manera el florecimiento de las Imágenes Aumentadas, en tanto que no solo representan un fragmento de la realidad, sino que también pueden constituir nuevas realidades potencialmente materializables.
VGS: Building a Statewide Legislative Simulation from an Idea to Final Gavel
Authors: Gentry Bobbi , Rackaway Chapman , Wintersieck Amanda
Published: January 2025

After a year of planning and preparation, the first ever intercollegiate Virginia Government Simulation opened with debate on the House of Delegates floor in October 2024. The original conception for VGS was modeled from other intercollegiate legislative simulations, but built on unique perspectives of faculty who were delegates themselves in college, taught simulations, or brought the simulation to life with gavels. This paper examines the strategies, choices, and success of VGS and tackles the learning moments throughout the process. We hope to make the process accessible, so that other faculty can give their students a once in a lifetime experience in their own state model legislatures.
Alpha-gal syndrome and the gastrointestinal reaction: a narrative review
Authors: Propst Susan B. H. , Thompson Dorothea K.
Published: January 2025

Gastrointestinal (GI) disturbances such as abdominal pain, nausea, and diarrhea are infrequently attributed to food allergies as an initial diagnosis in the absence of more traditional allergic reactions like hives, angioedema, or anaphylaxis. Alpha-gal syndrome (AGS) is an atypical and under-recognized allergy characterized by a delayed hypersensitivity reaction to the oligosaccharide galactose-α-1,3-galactose, a carbohydrate found in non-primate mammalian meat and derived products. This review of the current literature on AGS focuses on GI manifestations and diagnostic challenges. While clinical presentations of AGS vary widely, predominant or isolated GI symptoms, when manifested, can overlap with other disorders, thus making a timely and accurate diagnosis challenging. Here we provide an updated review of the epidemiology, pathophysiology, clinical presentation, and management of AGS. Current diagnostic approaches, treatment strategies, and areas requiring further research are also discussed.
Comprehensive safety and toxicity analysis of 2,2’-Bipyridine derivatives in combating MRSA biofilm formation and persistence
Authors: Priyanka  , Sharma Mohini , Vaid Bhavna , Bharti Ram , Raut Sachin , Jolly R. S. , Khatri Neeraj
Published: January 2025

Introduction

Methicillin-resistant Staphylococcus aureus (MRSA) infections have become arduous to treat due to their capacity to form biofilms, develop persistence, and exhibit significant antimicrobial resistance. These factors contribute to the complexity of managing MRSA infections and highlight the urgent need for innovative treatment strategies.

Objectives

This endeavor aims to evaluate the safety of 2,2’-Bipyridine (2,2’-Bipy) derivatives and their antimicrobial, anti-biofilm, and anti-persister activities in treating MRSA Infections.

Methods

Six derivatives were screened for their ADMET properties and tested for minimum inhibitory concentrations against various bacterial strains using agar well diffusion and broth dilution. Safety studies were conducted through hemolysis tests, cell viability assays, and in vivo acute oral toxicity examinations. Bactericidal mechanisms and biofilm disruption effects were analyzed using crystal violet staining and confocal microscopy assays. The murine thigh infection model was also used to investigate the in vivo efficacy.

Results

All derivatives exhibited favorable physicochemical profiles and ADMET properties and are predicted to be safe based on their drug-like properties. in vitro studies demonstrated that derivatives are non-toxic to 3T3 L1, and in vivo studies confirmed their safety in mice at a dose of 300 mg/kg and their non-hemolytic nature against rabbit red blood cells. All compounds showed potent antibacterial activity against the tested bacteria, including the resistant MRSA strain 831. They inhibited biofilm formation and eradicated biofilms in a dose-dependent manner against MTCC 737 and MRSA 831, and they effectively eliminated MRSA persister cells, outperforming the reference antibiotic vancomycin. These derivatives were found to depolarize the mitochondrial membrane and accumulate intracellular reactive oxygen species. These derivatives significantly reduced the bacterial load in the murine thigh infection model.

Conclusion

The study concluded that 2,2’-Bipy derivatives possess significant antimicrobial activity, are non-toxic, and are effective in inhibiting biofilm formation and killing persister cells.
Climate change and migration dynamics in Somalia: a time series analysis of environmental displacement
Authors: Mohamed Abdikadir Ahmed , Omar Ibtisam Mohamed , Yusuf Ibey Abdi Majid , Omar Mahdi Mohamed
Published: January 2025

Climate change is a significant driver of human migration, especially in vulnerable regions like Somalia. This study investigates the relationship between climate variables—average annual precipitation, temperature, and CO₂ emissions—and net migration in Somalia, using time series data from 1990 to 2020. Additionally, it examines the role of population growth as a factor influencing migration. Applying the Autoregressive Distributed Lag (ARDL) model, this research captures both short- and long-term dynamics, providing insights into how environmental and demographic factors impact migration in this climate-sensitive region. The results indicate that favorable rainfall conditions positively influence net migration, as improved agricultural productivity stabilizes livelihoods, reducing pressures to migrate. In contrast, increased CO₂ emissions, associated with environmental degradation, negatively impact migration by limiting financial capacity, creating a “trapped population” effect. Population growth also intensifies migration pressures by increasing competition for limited resources. Interestingly, temperature variations do not significantly influence migration, possibly due to adaptive strategies or resilience to temperature fluctuations in the region. These findings underscore the need for policies focused on enhancing agricultural resilience, restoring degraded environments, and creating economic opportunities to reduce migration pressures in Somalia. Investments in sustainable land use, climate adaptation, and population management strategies are essential to address the complex challenges of climate-induced migration.
The impact of type 2 diabetes on left ventricular function in hypertensive patients: a three-dimensional speckle-tracking imaging study
Authors: Qingmei Yang , Xiaoyan Chen , Jianxiu Fang
Published: January 2025

Objectives

The study aimed to evaluate the impact of the co-occurrence of hypertension and type 2 diabetes mellitus (T2DM) on the deterioration of left ventricular (LV) structure and function using three-dimensional speckle-tracking imaging (3D-STI), compared to patients with only hypertension.

Methods

Data from 272 hypertensive patients, including 85 with T2DM and 187 without, along with 45 normal controls, were analyzed. Participant characteristics were assessed before and after propensity score matching (PSM). 3D-STI-derived parameters, including LV function and global strain parameters, were compared among controls and different patient groups. Multivariable linear regression analyses were conducted to determine the impacts of T2DM on LV function and global strain. Additionally, linear mixed-effects regression models were used to evaluate the associations between 3D-STI-derived parameters and T2DM over time in hypertensive patients.

Results

Significant increases in the E/e' ratio and declines in the LV global radial strain (GRS) were observed across the control group, HTN (T2DM-) group, and HTN (T2DM+) group. After adjusting for various factors using PSM analysis, LV global circumferential strain (GCS) and global area strain (GAS) were also found to be significantly decreased in the HTN (T2DM+) group compared to the HTN (T2DM-) group. Multivariable regression analyses, accounting for various covariates, indicated that T2DM was independently linked to LV strains (LV GAS: β = 0.95, 95% CI: 0.90–1.00, p = 0.029; LV GRS: β = 1.03, 95% CI: 1.01–1.06, p = 0.014) in hypertensive patients. Furthermore, linear mixed-model analysis revealed that LV GCS (β = 1.20, 95% CI: 0.38–2.01, p = 0.004) and GRS (β = −2.82, 95% CI: −4.97–0.68, p = 0.010) deteriorated over the 12-month period.

Conclusions

T2DM exacerbates the decline in LV global and regional strains in patients with hypertension, and 3D-STI may be a valuable tool for detecting these asymptomatic preclinical abnormalities.
What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition?
Authors: Yap Nathan Angelo Lecaros , Khan Zahid , He Xingwei , Lee Jae-Geun , Maung Soe , Morgan Kimberley R. , Zhou Tingquan , Precht Helle , Serruys Patrick W. , Garcia-Garcia Hector M. , Onuma Yoshinobu , Hynes Sean , Kelle Sebastian , Mathur Anthony , Baumbach Andreas , Bourantas Christos V.
Published: January 2025

Accurate evaluation of coronary artery pathology is essential for risk stratification and tailoring appropriate treatment. Intravascular imaging was introduced for this purpose 40 years ago enabling for the first time in vivo plaque characterization. Since then, several studies have evaluated the efficacy of the existing intravascular imaging modalities in assessing plaque pathology and composition and their potential in guiding intervention and predicting vulnerable plaques. Today it is known that intravascular imaging is an indispensable tool in percutaneous coronary intervention planning, but the existing modalities have a limited efficacy in predicting lesion vulnerability; a fact that should be attributed to their advantages and limitations in accurately assessing morpho-pathological features that are common in advanced atherosclerotic plaques. This review aims to provide a comprehensive evaluation of the performance of intravascular imaging in characterizing plaque phenotypes using histology as a reference standard; it summarizes the studies comparing the available invasive imaging techniques against histology, discusses the findings and limitations of these studies and highlights the potential of novel intravascular imaging approaches that were introduced for a more complete and comprehensive evaluation of plaque pathobiology.
Video games and metacognition in the classroom for the development of 21st century skills: a systematic review
Authors: Checa-Romero Mirian , Gimenez-Lozano José Miguel
Published: January 2025

Introduction

Game-based learning is a methodology that has gained importance in the world of education due to the benefits of implementing ICT in the classroom. Due to the intellectual and competence demands that some commercial video games promote, they can be very valuable tools to stimulate and promote metacognitive abilities in students. Therefore, this paper aimed to analyze the use of commercial video games in educational contexts and their impact on the development of metacognitive skills.

Methods

For the analysis of the study, a systematic review of the literature was carried out following the PRISMA statement. Specialized databases such as Scopus, WoS, PsyInfo, PubMed, SciELO, and Eric were consulted, which helped capture the essence of the problem between 2004 and 2024.

Results

The review was then carried out on 10 selected articles. The results obtained show the following evidence: (a) commercial video games, together with the use of metacognitive strategies, enrich academic and social aspects as well as the metacognitive level, and (b) commercial video games are as effective in promoting metacognition as other more traditional methodologies or tools.

Discussion

Finally, there is a need to rethink the implications of the use of video games in the classroom if we want students to acquire skills that will be essential to successfully respond to the demands and challenges of their academic and professional future.
Dyscalculia and dyslexia in school-aged children: comorbidity, support, and future prospects
Authors: Han Weifeng
Published: January 2025

The comorbidity of dyscalculia and dyslexia represents a significant challenge in education, affecting a considerable number of school-aged children globally. This Mini Review synthesizes literature from the last decade (2015–2024) to provide an updated perspective on the prevalence, etiology, and educational implications of these co-occurring learning differences. Despite recent advancements in screening, diagnostic, and intervention tools, significant gaps remain in addressing the unique needs of children facing both dyscalculia and dyslexia. This review highlights the limitations of current research, particularly the scarcity of studies focused on culturally and linguistically diverse (CALD) populations and socio-economic disparities and explores the urgent need for more comprehensive, integrated approaches. Future directions include leveraging technological innovations, fostering interdisciplinary collaborations, and adopting neurodiversity-based educational models to support affected learners effectively. Addressing these gaps can foster an inclusive learning environment and improve outcomes for children navigating the complexities of both dyscalculia and dyslexia.
Clinical significance of hyperuricaemia in biopsy-proven diabetic kidney disease ━ a single-centre retrospective study
Authors: Yu Jin , Tu Xiao , Xu Kunyue , Tang Xuanli , Wu Yufan , Jiang Xue
Published: January 2025

Aims

Hyperuricaemia is associated with the development of Diabetic kidney disease (DKD). However, the mechanism of hyperuricaemia causing the progression of DKD remain unclear.

Methods

This is a single-centre retrospective study. 155 biopsy-proven DKD patients were grouped into hyperuricaemia and non-hyperuricaemia groups. Kaplan-Meier analysis and landmark curves were performed to explore predictors of end-stage renal disease (ESRD), Cox regression analysis was used to screen for factors, a nomogram was constructed to predict the renal prognosis of DKD.

Results

Patients in hyperuricaemia group had higher serum creatinine (Scr), degree of mesangial expansion and IFTA score and lower GFR, haemoglobin. SUA level was positively correlated with IFTA scores. The Kaplan-Meier curve and landmark analysis revealed worse survival in hyperuricaemia group, especially after 12 months. 11 variables, including age, sex, haemoglobin, Scr, SUA, and pathological score were collected to make a nomogram model. In the testing and training sets, the AUCs at 1, 3, and 5 years were 0.888, 0.939, and 0.886 and 0.947, 0.867, and 0.905, respectively.

Conclusion

The clinicopathologic manifestation of DKD patients with hyperuricaemia was much more severe, and hyperuricaemia predicted a worse renal prognosis. A new renal prognosis prediction model including SUA was constructed for DKD with higher accuracy.
Case report: A panorama gene profile of ovarian cancer metastasized to axillary lymph node
Authors: Xia Yu , Huang Yu , Liu Zheng , Song Siyuan , Wang Yi , Luo Jing
Published: January 2025

Background

Ovarian cancer is among the most lethal gynecologic malignancies, with a high proportion of patients diagnosed at advanced stages, leading to poor survival outcomes. Axillary lymph node metastasis from ovarian cancer is extremely rare and the mechanism is still unclear.

Methods

A comprehensive set of clinical and gynecologic oncology assessments were performed, including ultrasound, mammography, MRI, transvaginal ultrasound, and tissue staining. To unravel the carcinogenesis, the next-generation sequencing (NGS) was performed.

Results

Conventional examinations and imaging suggested the presence of both occult breast cancer and ovarian cancer. However, immunohistochemical staining confirmed the diagnosis of high-grade serous ovarian carcinoma. Further analysis of NGS identified two novel missense mutations, D326E in BTK (Bruton’s tyrosine kinase) at SH2 domain and D251E in EPHA5 (EPH receptor A5), along with other known cancer- associated mutations. These mutations, particularly the novel missense mutations, may lead to metastasis to the axillary lymph nodes and drug resistance. Therefore, based on these findings, the chemotherapy regimen was adjusted accordingly.

Conclusion

This is the first report on the panorama gene profile of ovarian cancer metastasis to axillary lymph node and we found two novel mutations (BTK pD326E and EPHA5 pD251E). This study unraveled the potential mechanism of genetic mutation for tumor metabolism, drug resistance, and metastasis.
Acoustic tags versus camera—a case study on feeding behaviour of European seabass in sea cages
Authors: Chen I-Hao , Georgopoulou Dimitra G. , Ebbesson Lars O. E. , Voskakis Dimitris , Munthe-Kaas Antonella Zanna , Papandroulakis Nikos
Published: January 2025

Intoduction

With the expansion of the aquaculture industry, the need arises for scalable, reliable, and robust methods to assess fish behaviour in sea cages to guide operational management, which includes feeding optimisation and welfare assessments. Fish cage monitoring utilising either acoustic transmitters or underwater cameras is well-studied. However, the relationship between those two different measurement types seems to have not been explored, nor have they been evaluated together in one experimental site.

Methods

In our 1-month study, we compared the activity of 14 sentinel fish and the artificial intelligence (AI)-inferred speed of individuals from the European seabass (Dicentrarchus labrax) sea cage population in three feeding trials. Comparisons include a maximum activity comparison using persistent peaks, fish behavioural pattern establishment and retention, and periodical behavioural patterns.

Results

Our results demonstrate that under certain circumstances, both technologies are interchangeable from the perspective of persistent peaks and periodicity, but complementary when it comes to behaviour analysis such as food anticipatory behaviour (FAB).

Discussion

We anticipate that our findings will stimulate advances where multiple sensor types are in use to achieve a more holistic understanding of fish behaviour in the aquaculture sector using underwater technologies.
Association between intrahepatic cccDNA and the severity of liver inflammation in chronic hepatitis B virus infection patients
Authors: Zhao Suxian , Dong Chen , Chang Chudi , Zhang Jiaming , Li Jing , Zhang Xiaoxiao , Ren Weiguang , Zhang Ying , Nan Yuemin
Published: January 2025

Background and aims

This research aimed to examine the association between hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and liver inflammation in chronic hepatitis B (CHB) infection patients.

Methods

From August 2013 to June 2022, CHB patients at Hebei Medical University Third Hospital (Hebei, China) were recruited. Intrahepatic cccDNA was quantified and its association with liver inflammation was analyzed. Liver inflammation was assessed using the Ishak-modified histological activity index (HAI). Biochemical and viral indicators as well as hepatic inflammation biomarkers were monitored.

Results

In total, 55 CHB patients were enrolled. The average HBV-cccDNA level was markedly elevated in HBeAg+ patients compared to HBeAg patients. Intrahepatic cccDNA levels differed significantly in different liver inflammation groups and showed a positive correlation with the HAI score for hepatic inflammation.

Conclusion

HBV-cccDNA level was associated with liver inflammation.
Progress in the role of nanoparticles in the diagnosis and treatment of bone and joint tuberculosis
Authors: Ding Yitong , Li Baiyun , Yi Yangfei , Liu Can , Wen Jie , Jian Xiaohong , Li Yufei
Published: January 2025

Bone and joint tuberculosis (BJTB), caused by Mycobacterium tuberculosis (MTB), is a prevalent form of extrapulmonary tuberculosis that poses significant challenges to global public health due to difficulties in early diagnosis, prolonged treatment cycles, and drug resistance. Recent advancements in nanotechnology have introduced novel solutions for the early detection and precise treatment of BJTB, leveraging unique physicochemical properties such as high specific surface area, targeted delivery capabilities, sustained drug release, and excellent biocompatibility. In diagnostic applications, nanomaterials markedly enhance the sensitivity and accuracy of detection methods while reducing testing time. These technologies are adaptable to resource-limited settings, enabling earlier patient intervention and mitigating disease progression risk. In therapeutic applications, nanomaterials prolong drug retention in bone tissue through targeted delivery, thereby decreasing medication frequency and minimizing toxic side effects, which significantly improves treatment efficacy. Despite substantial progress, further research is required to address long-term safety concerns, broaden clinical applicability, and evaluate performance under complex pathological conditions. This review summarizes recent advancements in nanomaterials for diagnosing and treating BJTB and identifies key areas for future research, laying the groundwork for advancing precision medicine and personalized treatments.
Infusion line contamination in preterm neonates: impact of infusion line design, length, and use duration: the multicenter ChronoBIOline study
Authors: Dos Santos Sandra , Valentin Anne-Sophie , Farizon Mathilde , Charbonneau Manon , Boukhris Mohamed Riadh , Brat Roselyne , Cazzorla Fabiana , Chauvel Jennifer , Cneude Fabrice , Coutable Pauline , Demasure Maryvonne , Duminil Emeline , Faraut-Derouin Vénonique , Muselli Maud Gits , Gorin Valérie , Goujon Rosemary , Guillouche-Puissant Melinda , Hacinlioglu Nadine , Landelle Caroline , Lefebvre Annick , Leroy-Terquem Elise , Martinet Aurore , Massebeuf Camille , Orfanos Nadia Mazille , Menard Guillaume , Menvielle Laure , Monin Vanessa , Morange Virginie , Patkai Juliana , Perrault Nathalie , Prat Emilie , van der Mee-Marquet Nathalie
Published: January 2025

Introduction

Central venous catheters are critical in preterm neonatal care but increase the risk of central line-associated bloodstream infections (CLABSIs). The incidence of S. haemolyticus-associated CLABSIs in French neonates is increasing, but the mechanisms underlying this trend remain unclear.

Methods

We examined microorganisms in 108 central line infusion sets used in preterm infants across 12 neonatal intensive care units, and collected at the time of removal.

Results

The infusion sets varied widely in type (28 types; 1-6 parts) and length (10-180 cm, mean 52.9 cm). Contamination was detected in 24 infusion sets (22.2%), mainly by coagulase-negative Staphylococci (50.0%) and Bacillus species (41.7%). Higher contamination rates were linked to longer infusion lines (> 50 cm; p < 0.001), usage beyond 7 days (p = 0.002), and multi-line infusion systems (p < 0.001).

Discussion

Our findings are fully consistent with guidelines, which recommend simpler designs and a 4 or 7-day use of infusion sets, emphasizing the importance of adhering to these guidelines to reduce the risk of CLABSIs. Additionally, our findings raise concerns regarding the use of multi-line infusion systems. These devices, which combine extended infusion line length, manufacturer-authorized use of up to 21 days, and intermittent use of certain infusion lines, are easily contaminated during use, creating a high-risk situation for central line contamination.
Translingual neural stimulation induced changes in intra- and inter-network functional connectivity in mild-moderate traumatic brain injury patients
Authors: Chu Daniel Y. , Hou Jiancheng , Hosseini Thomas , Nair Veena A. , Adluru Nagesh , Danilov Yuri , Kaczmarek Kurt A. , Meyerand Mary E. , Tyler Mitchell , Prabhakaran Vivek
Published: January 2025

Introduction

Mild-to-moderate traumatic brain injury (mmTBI) that lead to deficits in balance and gait are difficult to resolve through standard therapy protocols, and these deficits can severely impact a patient's quality of life. Recently, translingual neural stimulation (TLNS) has emerged as a potential therapy for mmTBI-related balance and gait deficits by inducing neuroplastic changes in the brain gray matter structure. However, it is still unclear how interactions within and between functional networks in brain are affected by TLNS. The current study aimed to extend our previous resting-state functional connectivity (RSFC) study investigating the effects of TLNS intervention on outcome measures related to gait and balance.

Methods

An experimental PoNS device was utilized to deliver the TLNS. The 2-week TLNS intervention program, specifically stimulation during focused physical therapy focused on recovery of gait and balance, included twice-daily treatment in the laboratory and the same program at home during the intervening weekend. The resting-state fMRI datasets at pre- and post-interventions were collected by 3T MRI scanner with nine mmTBI patients. All participants also received both Sensory Organization Test (SOT) and Dynamic Gait Index (DGI) testing pre- and post-intervention as part of the behavioral assessment.

Results

Compared to baseline, TLNS intervention led to statistically significant improvements in both the SOT [t(8) = 2.742, p = 0.028] and the DGI [t(8) = 2.855, p = 0.024] scores. Moreover, significant increases in intra- and inter-network RSFC were observed, particularly within the visual, default mode, dorsal attention, frontoparietal (FPN), and somatosensory (SMN) networks. Additionally, there were significant correlations between the SOT and inter-network FC [between FPN and SMN, r(9) = –0.784, p = 0.012] and between the DGI and intra-network FC [within SMN, r(9) = 0.728, p = 0.026].

Discussion

These findings suggest that TLNS intervention is an effective in increasing somatosensory processing, vestibular-visual interaction, executive control and flexible shifting, and TLNS may be an effective approach to inducing brain network plasticity and may serve as a potential therapy for mmTBI-related gait and balance deficits.
Efficacy of fish oil supplementation on metabolic dysfunction-associated steatotic liver disease: a meta-analysis
Authors: Zhou Like , Sun Dongmei , Bai Houqiao
Published: January 2025

Objective

Globally, the occurrence of Metabolic dysfunction-associated steatotic liver disease (MASLD) is on a steady rise. Fish oil has anti-inflammatory effects and can improve lipid metabolism. The article aims to assess the impact of fish oil supplementation on MASLD.

Methods

We conducted a systematic search of Cochrane, Embase, PubMed, and Web of Science up to September 31, 2024, for randomized control trials (RCTs). The risk of bias of the included RCTs was evaluated using the Cochrane Collaboration’s tool. Outcomes measured were aspects of liver injury, lipid profile, insulin resistance, anthropometric measurements, and more.

Results

Seven randomized controlled trials (RCTs) involving 439 participants were incorporated into the analysis. In general, the risk of bias in these RCTs was either low or not clearly defined. Pooled analysis showed that triglycerides [TG, pooled standard mean difference (SMD): −0.40 (95% CI: −0.58 to −0.21)], aspartate transaminase [AST, SMD: −0.29 (95% CI: −0.48 to −0.10)], HOMA-IR [SMD: −2.06 (95% CI: −3.36 to −0.49)] and waist circumference [Waist-C, SMD: −0.31 (95% CI: −0.54 to −0.08)] were significantly improved. But showed no significant benefits on alanine transaminase [ALT, SMD: −0.15 (95% CI: −0.45 to 0.15)], gamma-glutamyl transpeptidase [GGT, SMD: −0.07 (95% CI: −0.26 to 0.12)], body mass index [BMI, SMD: 0.16 (95% CI: −0.34 to 0.02)], high-density lipoprotein cholesterol [HDL, SMD: 0.02 (95% CI: −0.18 to 0.22)], low-density lipoprotein cholesterol [LDL, SMD: −0.01 (95% CI: −0.20 to 0.18)], Total Cholesterol [TC, SMD: −0.34 (95% CI: −0.70 to 0.01)] and so on.

Conclusion

The current evidence supports the fish oil supplementation in improving MASLD. Fish oil supplementation may also regulate blood lipids and improve glucose metabolism disorders.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/#myprospero, identifier CRD42024513246.