bluuebunny/crossref_metadata_2025 huggingface dataset:
Editorial: Artes Visuais, imaginários de esquerda e capitalismo na América Latina
Authors: Bugnone Ana , Fetter Bruna , Cabral de Lira Jordao Fabricia , Cavalcanti Raiza , Fabris Yasmin , De la rosa Natália
Published: November 2024

Editorial
Artes Visuais, imaginários de esquerda e capitalismo na América Latina
 
O imaginário revolucionário cumpre um papel importante na relação entre arte e política. Inclusive, foi a violência revolucionária e o laicismo iconoclasta da Revolução Francesa que produziu a noção moderna de arte (Groys, 2021). Na América Latina, a partir da década de  1960, os imaginários atrelados às revoluções francesa e soviética foram atualizados e reformulados desde as experiências históricas coloniais, o triunfo da revolução cubana (1953-1959) e os sucessivos golpes de Estado que estabeleceram governos ditatoriais no Brasil (1964), Bolívia (1964), Argentina (1966 e depois em 1976), Chile (1973) e Uruguai (1973). Para Ana Longoni (2014), vanguarda e revolução funcionaram como “ideias-forças” na arte desse período. A associação entre revolução e vanguarda, sobretudo nos primeiros anos das ditaduras militares do Cone Sul, redefiniu o papel da arte e dos artistas. 
O léxico político-ideológico assume o protagonismo nos enunciados, nas produções poéticas de artistas e nas formulações críticas e teóricas do continente, agregando novas camadas de significação para o gesto artístico, agora convertido em ação revolucionária. No Brasil, o ideário ético-político-estético vigente no período se evidenciou em conceituações como “geração tranca-ruas” (Bittencourt, 1970) e “arte de guerrilha” (Morais, 1970), empregadas por críticos e artistas na tentativa de dar unidade e, ao mesmo tempo, distinguir uma vasta e
diversificada produção que foi difundida em mostras como Opinião 65 (1965), Arte no Aterro (1968), Do corpo à Terra (1970) e Domingos de criação (1971). 
No entanto, a crença na possibilidade de produzir uma forma artística revolucionária, a partir do paradigma da intervenção da experiência estética na realidade social, subjacente à relação arte e política dentro do espectro socialista, rapidamente encontrou seu limite. A partir daí,  diversos artistas entraram em um impasse: como constituir um imaginário político nas artes visuais que não estivesse atrelado a projetos políticos-revolucionários instrumentalizadores do estético, e que também valorizavam o uso da violência, do matar e do morrer, como opção legítima da atividade política?
Subwavelength topological interface modes in a multilayered vibroacoustic metamaterial
Authors: Gzal Majdi O. , Tempelman Joshua R. , Matlack Kathryn H. , Vakakis Alexander F.
Published: November 2024

We present a systematic and rigorous analytical approach, based on the transfer matrix methodology, to study the existence, evolution, and robustness of subwavelength topological interface states in practical multilayered vibroacoustic phononic lattices. These lattices, composed of membrane-air cavity unit cells, exhibit complex band structures with various bandgaps, including Bragg, band-splitting induced, local resonance, and plasma bandgaps. Focusing on the challenging low-frequency range and assuming axisymmetric modes, we show that topological interface states are confined to Bragg-like band-splitting induced bandgaps. Unlike the Su-Schrieffer-Heeger model, the vibroacoustic lattice exhibits diverse topological phase transitions across infinite bands, enabling broadband, multi-frequency vibroacoustics in the subwavelength regime. We establish three criteria for the existence of these states: the Zak phase, surface impedance, and a new reflection coefficient concept, all derived from transfer matrix components. Notably, we provide an explicit expression for the exact location of topological interface states within the band structure, offering insight for their predictive implementation. We confirm the robustness of these states against structural variations and identify delocalization as bandgaps narrow. Our work provides a complete and exact analytical characterization of topological interface states, demonstrating the effectiveness of the transfer matrix method. Beyond its analytical depth, our approach provides a useful framework and design tool for topological phononic lattices, advancing applications such as efficient sound filters, waveguides, noise control, and acoustic sensors in the subwavelength regime. Its versatility extends beyond the vibroacoustic systems, encompassing a broader range of phononic and photonic crystals with repetitive inversion-symmetric unit cells.
Feeding chicory silage, but not Se-yeast or a single injection of inorganic Se, affects metabolism, fat in milk, and type I immunity in transition ewes
Authors: Ford Hunter , Hasan Daniella , Ates Serkan , Puerto-Hernandez Gracia , Klopfenstein Joseph J. , Trevisi Erminio , Smallman Mary , Matra Maharach , Bionaz Massimo
Published: November 2024

In the study, we assessed the effect on performance and health of a single injection of inorganic Se prepartum or feeding chicory silage and organic Se supplementation during the peripartum in ewes. Approximately one month before lambing, 45 pregnant Polypay ewes were moved into single pens and randomly assigned to 5 groups to be fed either grass or chicory silage and supplemented or not with 3.6 mg Se/day as selenium yeast or given a single prepartum injection of Na-selenite. Daily dry matter intake (DMI), water intake, milk production and components, blood metabolic, immune and inflammatory parameters, and blood micromineral levels were measured. DMI was lower in ewes fed chicory silage, although no statistical differences in milk yield were observed. Very few differences were observed in milk components, except fat %, which was higher among ewes fed chicory silage. The type of silage had a significant effect on the fatty acid profile of the milk, with the milk from ewes fed chicory having a higher proportion of unsaturated fatty acids and overall improved health indices compared to the milk from ewes fed grass silage. Blood NEFA and BHBA were higher in ewes fed chicory vs. grass silage. Neither silage type nor Se supplementation had a strong effect on most of the parameters associated with immune or inflammatory function, except for the liver enzymes GGT and GOT, which were lower, and a larger type I/type II ratio immune response measured by the DxD2 assay among ewes fed chicory vs. grass silage. No effects on parasite fecal egg counts were observed. Supplementation of ewes with Se-yeast resulted in higher blood levels of Se, whereas the one-time prepartum injection had no significant effect on whole blood Se levels. Feeding chicory silage and supplementing Se during the transition period had a minimal impact on ewe performance and health.
Numerical study on a new adjustable multi-hole throttling device for natural gas flooding
Authors: Xing Xuesong , Chen Huan , Ma Yingwen , Yu Jifei , Xue Dedong , Zou Minghua , Kou Lei
Published: November 2024

Natural gas flooding represents a significant technique for the enhancement of oil recovery, thereby facilitating the efficient utilization of oil and gas resources. In the injection and production system, the throttling gas nozzle is a key component that adjust the injection pressure according to the reservoir’s pressure. However, current throttling gas nozzles utilize a fixed structure, which presents a challenge in achieving online control of flow rate and pressure drop. Therefore, a new adjustable multi-hole throttling device was proposed in this paper, allowing for the regulation of pressure loss by changing the number of flowing holes. In order to gain insight into the operational principles and pressure drop characteristics of this new throttling device, the SST k-ω turbulence model and the NIST physical property model were employed to simulate the supercritical natural gas flow in the nozzle. The results demonstrate that there is an uneven distribution of velocity between the channels of the downhole multi-hole throttling device. The velocity in a single nozzle channel exhibits a trend of initially increasing rapidly and then decreasing, while the pressure exhibits an initial decrease, which is then followed by a slight increase. The pressure drops of the nozzle under different flow rates and flowing hole numbers were acquired, revealing that the pressure drop of the multi-hole throttling device is inversely proportional to the number of holes. The adjustment accuracy of pressure drop and flow rate is higher when the number of holes is between 4 and 6. However, a significant increase in pressure drop occurs when the number of holes is less than 3, resulting in poorer regulation accuracy. Furthermore, a pressure drop prediction model was developed based on the numerical results, which provides guidance for the application and design of the throttling device. In this study, a new natural gas flooding throttling device is proposed, offering a new approach for downhole equipment development. Additionally, this research provides guidance for the practical application and iterative improvement of this throttling device in future use.
Apigeninidin chloride disrupts Toxoplasma gondii Mitochondrial membrane potential and induce reactive oxygen species and metabolites production
Authors: Moon Miya Janelle , Kamasah Japhet Senyo , Sharma Homa Nath , Robertson Boakai K. , Abugri Daniel A.
Published: November 2024

Introduction

Apigeninidin chloride (APi) is a form of 3-deoxyanthrocyanidins (3-DAs) abundantly produced by the red Sorghum bicolor plant. It has been previously reported to be effective against Toxoplasma gondii (T. gondii) tachyzoites grown in vitro with less cytotoxic effect. However, its possible mechanism(s) of action has not been elucidated. Biochemically, we discovered that APi induced high reactive oxygen species (ROS) and mitochondria superoxide (MitoSOX) productions in tachyzoites, leading to mitochondrial membrane potential (MMP) disruption in vitro.

Methods

To confirm our biochemical results at the molecular level, we performed a liquid chromatography-mass spectrometry (LC-MS) analysis on APi-treated parasites to assess any metabolite and lipid alterations often associated with high ROS/MitoSOX production in cells.

Results

Noteworthy is that we detected several important oxidative stress-induced metabolites such as hexanal, aldehydes, methyl undeo10-enoate, butadiynyl phenyl ketone, 16-hydroxyhexadecanoic acid (16-OH, 16:0), 2-hydroxytricosanoic acid (C23:0; O), 3-oxodecanosanoic acid (C22:1; O), 2-hydroxypropylsterate, and furan fatty acids F6 (19FU-FA).

Discussion

These metabolites are associated with lipid, protein, and nucleic acid disruptions. Using atovaquone (Atov) as a control, we observed that it disrupted intracellular tachyzoites’ mitochondrial membrane potential, increased ROS and MitoSOX production, and altered metabolite and lipid production similar to what was observed with our experimental compound APi. Overall, our results indicated that APi targets T. gondii tachyzoite growth through inducing oxidative stress, mitochondrial dysfunction, and eventually parasite death.
Gesture alignment in teacher–student interaction: a study concerning office hour consultations using English as the lingua franca
Authors: Opazo Paloma , Cienki Alan , Oben Bert , Brône Geert
Published: November 2024

Introduction

In this study, we explore the presence of gesture alignment in office hour consultations, a form of academic talk characterized by private face-to-face dialogues between a lecturer and a university student. Unlike classroom interactions, the topic of these consultations is initiated by the student. Our objectives were to describe the patterns of gesture alignment in these educational settings, to determine the direction of the copied behavior (i.e., who copies whom?), and to understand the temporal structuring of these instances.

Methods

We analyzed 12 office hour consultations, involving Spanish undergraduate students and lecturers from universities in England, Ireland, and Sweden. All the conversations were held in English. The annotation considered three domains: the timing of matching gestures (i.e., if the aligned gestures appeared in a Simultaneous, Consecutive, or Later manner), the form features of the aligned gestures (hand shape, movement, and orientation), and the function of the gestures (representational, deictic, or pragmatic).

Results

Our results show that although there are important differences between dyads, there were four general findings. First, aligned gestures mostly took place in a Consecutive manner. Second, gesture alignment is shown to achieve shared understanding between interactants, but this can be manifested in different ways: from the active negotiation of meaning to the signaling of agreement. Third, paired gestures become useful in educational contexts where the teachers and students include native and non-native speakers, as they contribute to disambiguating meaning. Fourth, many cases of matching gestures happen due to the presence of recurrent gestural forms.

Discussion

Overall, our results are in line with previous evidence that has highlighted the role of gesture alignment in grounding processes, related to the achievement of mutual agreement between participants. Matching gestures are a helpful resource during office hour consultations—a form of academic talk where content is being explained and negotiated.
Association of metabolic score for insulin resistance with progression or regression of prediabetes: evidence from a multicenter Chinese medical examination cohort study
Authors: Sheng Guotai , Kuang Maobin , Yang Ruijuan , Zou Yang
Published: November 2024

Objective

Few studies have evaluated the changes in blood glucose status in individuals with prediabetes, and this study aimed to analyze the association between metabolic score for insulin resistance (MetS-IR) and the progression or regression of prediabetes.

Methods

This retrospective cohort study used research data from medical examination institutions under the Rich Healthcare Group in 32 regions across 11 cities in China. Progression of prediabetes to diabetes and regression to normal fasting glucose (NFG) were defined based on glycemic changes during follow-up. The association between MetS-IR and the progression or regression of prediabetes was analyzed using multivariate Cox regression, restricted cubic splines, and piecewise regression models.

Results

Data from 15,421 prediabetic subjects were analyzed. Over an average follow-up of 2.96 years, 6,481 individuals (42.03%) returned to NFG, and 2,424 (15.72%) progressed to diabetes. After controlling for confounding factors, an increase in MetS-IR was observed to increase the risk of diabetes onset in the prediabetic population, whereas a decrease in MetS-IR had a protective effect for returning to NFG. Additionally, a nonlinear relationship between MetS-IR and prediabetes regression was observed, with 37.22 identified as the inflection point; prediabetes regression rates were significantly higher before this point and markedly decreased after it.

Conclusion

For individuals with prediabetes, an increase in MetS-IR may lead to an increased risk of diabetes; conversely, a decrease in MetS-IR enhances the protective effect for returning to NFG and keeping MetS-IR below 37.22 is significant for the regression of prediabetes.
A U-shaped relationship between the atherogenic index of plasma and repeated target vessel revascularization in patients undergoing percutaneous coronary intervention: a retrospective study
Authors: Huang Xingjie , Wen Song , Huang Zehan , Qin Guishi , Zhou Hanli , Xia Zhonghua
Published: November 2024

Background

Atherogenic index of plasma (AIP) has been recognized as a novel and practical marker for the assessment of cardiometabolic risk, but the relevance of AIP as a prognostic biomarker in coronary artery disease (CAD) remains debated. This study investigated the association between AIP and major adverse cardiac and cerebrovascular events (MACCEs) in CAD patients receiving percutaneous coronary intervention (PCI) with drug-eluting stents (DES).

Methods

A total of 2,250 patients undergoing PCI with DES were included in this retrospective cohort study. The primary endpoint was MACCEs, encompassing acute myocardial infarction, repeat target vessel revascularization (TVR), stroke, and all-cause mortality. Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines were applied to explore the dose–response associations. And subgroup analysis was conducted to evaluate potential relationship between AIP and MACCEs across different subgroups.

Results

During a medium follow-up of 29.8 (25.6–34.0) months, 106 (4.7%) patients experienced TVR. After adjusting for confounders, AIP (per 1 SD increase) was positively associated with TVR (odds ratio [OR] = 1.26, 95% confidence interval [CI] = 1.01–1.58, P = 0.042). In females, there was a significant association (OR = 2.33, 95% CI = 1.40–3.98, P = 0.002), but no significant association was observed in males. There was an interaction between AIP and gender (P = 0.017). Restricted cubic spline analysis depicted a U-shaped relationship between AIP and TVR (Pnonlinear = 0.016), with an elevated risk evident from an AIP of 0.20.

Conclusion

AIP showed a U-shaped relationship with TVR in PCI patients with DES, particularly pronounced among females. We suggested that the AIP should be used as a plasma marker of key interest for preventing TVR after DES implantation in patients with CAD.
Dysregulated CD38 expression on T cells was associated with rapidly progressive interstitial lung disease in anti-melanoma differentiation-associated gene 5 positive dermatomyositis
Authors: Guo Yixue , Liu Hongjiang , Chen Bo , Zhang Keyi , Meng Liye , Yan Lin , Niu Qian , Zhang Junlong , Yin Geng , Li Yi
Published: November 2024

Background

Anti-melanoma differentiation-associated gene 5 positive dermatomyositis (MDA5+ DM) is a life-threatening disease due to rapidly progressive interstitial lung disease (RP-ILD). We aimed to investigate the expression profile of T cell subsets in MDA5+ DM patients, seeking for possible disease-causing T cell subsets and potential biomarkers to distinguish ILD, especially RP-ILD patients.

Methods

Peripheral blood T cell subpopulations were immunophenotyped in 24 MDA5+ DM patients and 21 healthy controls (HCs) by flow cytometry. The proportion of T cell subsets and clinical characteristics were analyzed. The quantitative determination of cytokines in the plasma was measured by using a microsphere-based immunofluorescence assaying kit.

Results

The proportion of naïve and CD38+ T cells were much higher, whereas the proportion of central memory T cells were lower in MDA5+ DM patients than in HCs. Notably, the proportion of CD38+CD4+ T cells and CD38+CD8+ T cells on T cells in in RP-ILD group were significantly elevated compared to C-ILD, non-ILD group and HCs. Moreover, serum IFN-α levels were significantly increased in MDA5+ DM patients with RP-ILD. Further, the frequencies of CD38+CD4+ T cells and CD38+CD8+ T cells were positively correlated with IFN-α levels. Finally, ROC analysis indicated that CD38+CD4+ T cells and CD38+CD8+ T cells could be potential biomarkers for predicting ILD/RP-ILD in MDA5+ DM patients.

Conclusion

Dysregulated CD38 expression on T cell subsets was associated with lung involvement, especially RP-ILD in MDA5+ DM patients. CD38+ T cell subsets could be used as potential biomarkers for predicting ILD/RP-ILD in MDA5+ DM patients.
Angiotensin type-1 receptor autoantibodies promote alpha-synuclein aggregation in dopaminergic neurons
Authors: Lage Lucia , Rodríguez-Perez Ana I. , Labandeira-Garcia Jose L. , Dominguez-Meijide Antonio
Published: November 2024

Angiotensin, through its type-1 receptor (AT1), is a major inducer of inflammation and oxidative stress, contributing to several diseases. Autoimmune processes have been involved in neurodegeneration, including Parkinson’s disease (PD). AT1 autoantibodies (AT1-AA) enhance neurodegeneration and PD, which was related to increased neuronal oxidative stress and neuroinflammation. However, the effect of AT1-AA on α-synuclein aggregation, a major factor in PD progression, has not been studied. In cultures of dopaminergic neurons, we observed that AT1-AA promote aggregation of α-synuclein, as AT1-AA upregulated major mechanisms involved in the α-synuclein aggregation process such as NADPH-oxidase activation and intracellular calcium raising. The results further support the role of AT1 receptors in dopaminergic neuron degeneration, and several recent clinical studies observing the neuroprotective effects of AT1 receptor blockers.
Immunogenicity of dupilumab in adult and pediatric patients with atopic dermatitis
Authors: Kamal Mohamed A. , Kosloski Matthew P. , Lai Ching-Ha , Partridge Michael A. , Rajadhyaksha Manoj , Kanamaluru Vanaja , Bansal Ashish , Shabbir Arsalan , Shumel Brad , Ardeleanu Marius , Richards Susan M. , Yan Hong , Xu Christine R. , Rodríguez-Marco Ainara , Xiao Jing , Khokhar Faisal A. , Gherardi Guy , Babilonia Elisa , Maloney Jennifer , Mortensen Eric , Akinlade Bolanle , Braunstein Ned , Stahl Neil , Torri Albert , Davis John D. , DiCioccio A. Thomas
Published: November 2024

Background

Development of anti-drug antibodies (ADAs) and neutralizing antibodies (NAbs) to monoclonal antibodies may adversely impact pharmacokinetics, efficacy, and/or safety.

Objective

To describe incidence, titer, and persistence of dupilumab ADAs and NAbs, and their effects on pharmacokinetics, efficacy, and safety in patients with atopic dermatitis (AD).

Methods

This analysis included seven phase 3 randomized, placebo-controlled (N=2,992) and two long-term open-label extension (N=2,287) trials of subcutaneous dupilumab in adults and pediatric patients with moderate-to-severe AD. ADA, NAb, and dupilumab concentration in serum were assessed using validated immunoassays. ADA impacts on efficacy (EASI) and safety were assessed.

Results

Treatment-emergent ADAs were observed in up to 8.6% (aged ≥18 years), 16.0% (12-17 years), 5.3% (6-11 years), and 2.0% (6 months to 5 years) dupilumab-treated patients. Among dupilumab-treated patients, ≤3.7% had persistent responses, <1% had high titers (≥10,000), and ≤5.1% were NAb-positive. NAbs were more common in patients with moderate- and high-titer ADA responses. High-titer ADAs, while infrequent, were the variable most associated with lower dupilumab concentrations in serum and loss of efficacy, independent of NAb status. Efficacy was generally similar in ADA-positive and -negative patients. For most patients with high- or moderate-titer ADAs, titers decreased and efficacy improved over time with continued dupilumab treatment. ADA-positive and -negative patients had similar incidences of treatment-emergent and serious treatment-emergent adverse events. One patient with high-titer ADAs developed serum sickness.

Conclusion

In patients with AD, ADAs and NAbs had minimal impact on dupilumab concentration, efficacy, and safety, except for high-titer ADAs in a small number of patients.

Clinical trial registration

ClinicalTrials.gov, identifiers (NCT02277743, NCT02277769, NCT02260986, NCT02395133, NCT01949311, NCT03054428, NCT03345914, NCT02612454, and NCT03346434).
Comparison of adjuvant treatment regimens for high-risk hepatocellular carcinoma: a Bayesian network meta analysis and systematic review
Authors: Li Jiahao , Liu Yingnan , Qiu Yuqi , Qu Chao , Li Jiarui
Published: November 2024

Background

The five-year recurrence rate for patients with hepatocellular carcinoma (HCC) is as high as 70%. Patients with high-risk recurrence factors experience significantly poorer prognosis. Local regional therapies, including transarterial chemoembolisation (TACE), hepatic arterial infusion chemotherapy (HAIC), radiotherapy, and emerging immunotherapy, are commonly used adjuvant treatment options. We conducted an indirect comparison of these adjuvant therapies for such patients.

Methods

We conducted a systematic search in public databases for relevant studies and assessed the efficacy and safety of the corresponding therapies by consolidating disease-free survival (DFS), overall survival (OS), and adverse events (AEs).

Results

A total of eight randomised controlled trials were ultimately included. The Gelman-Rubin plot and kernel density estimation indicate that the stability of the combined model is satisfactory.

Conclusion

immunotherapy is not inferior to local regional therapies in delaying tumour recurrence, however, the higher incidence of AEs remains a significant concern. Adjuvant radiotherapy demonstrated superior efficacy in delaying tumour recurrence compared to adjuvant TACE, although further support from phase III clinical trial evidence is required.

Systematic review registration

https://www.crd.york.ac.uk/prospero/, identifier CRD42024576316.
Casting a sustainable future: a study on dynamic prediction and influencing factors of economic resilience in fisheries management
Authors: Chen Xiaoyu , Wang Haohan , Zhang Yujie
Published: November 2024

Marine fisheries are a critical component of the marine economy. Examining the changes in the economic resilience of marine fisheries allows for identifying potential development risks and supports informed decision-making to optimize growth patterns and mitigate risks. This study applied the CRITIC-based combined weights model to calculate China’s Marine Fisheries Economic Resilience (MFER). It investigated the temporal and spatial evolution of MFER and analyzed the influencing factors using the Geographical Detector and a Two-way fixed-effects model. Furthermore, the future development trends of MFER were predicted using the Markov chain. The results show that the overall MFER in China’s coastal provinces increased steadily from 2001 to 2020. Second, MFER exhibits a clear pattern, with low-value regions improving and high-value areas shifting toward medium- and low-value provinces. Fourth, the trajectory of the MFER center is moving from north to south, with high-value regions expanding in the same direction. Fourth, factors such as EDL, TEC, SPE, and SYS positively impact MFER, while OPE has a negative effect. Finally, the results of the Markov chain indicate that the current development state of MFER is relatively stable, with evidence of club convergence. However, the probability of maintaining the current development level is gradually decreasing. Based on these findings, provide suggestions for the preservation of marine economic security.
Source apportionment of organic carbon and black carbon in the surface sediments of the Pearl River Estuary and its adjacent South China Sea: insight from stable carbon and nitrogen isotopes
Authors: Cao Ruixue , Lao Qibin , Huang Chao , Han Jiajun , Jin Guangzhe , Lu Xuan , Cai Minggang , Chen Chunqing , Chen Fajin
Published: November 2024

Coastal estuaries and adjacent continental shelf seas constitute vital global carbon reservoirs, and the sources and transformations of organic carbon in these regions are crucial to global biogeochemical cycles and climate change. This study investigated the total organic carbon (TOC), total nitrogen (TN), black carbon (BC), and their stable carbon and nitrogen isotopes (δ15NTN, δ13CTOC, δ13CBC) in the surface sediments of the Pearl River Estuary (PRE) and its adjacent northern South China Sea (NSCS) aiming to assess the impact of human activities on organic carbon dynamics in these areas. Results showed that the highest TOC concentrations occurred in the inner PRE due to intense human activities, and decreased seaward. The west side of the PRE exhibited higher TOC levels than the east side, which was attributed to differences in hydrodynamic processes and human activities. The westward flow of the Pearl River diluted water, which carried terrestrial organic matter inputs due to the influence of the Coriolis effect and intense local human activities, was a primary contributor to higher TOC levels on the west side (terrestrial source). In contrast, increased productivity and intensive mariculture activities on the east side predominated as sources of organic matter (marine source). Similar to the TOC, BC and TN sources were mainly influenced by human activities. δ15NTN distribution shows that TN in the east side of PRE mainly originated from industrial wastewater input from the Pearl River, while in the east side TN was mainly from domestic sewage discharge. Additionally, BC sources have shifted from primarily biomass combustion in the 1990s to fossil fuel emissions presently. Isotopic analysis revealed that over 70% of BC originated from fossil fuel inputs and C3 plant combustion, highlighting the significant influence of human activities in the PRE and adjacent NSCS, and underscoring the need for effective management and protection of the eco-environment in these regions.
Case report: A case of blood culture-negative Bartonella quintana endocarditis: blood mNGS is an efficient method for early diagnosis
Authors: Pu Jun-fan , Zhou Yan-ling , Deng Min , Wu Jing
Published: November 2024

Bartonella quintana is one of the main causes of blood culture-negative endocarditis, and routine blood culture and serological methods are difficult to achieve early diagnosis. We report a case of blood culture-negative Bartonella quintana endocarditis from southwestern Chongqing. The patient was a 67-year-old male scavenger who presented with heart failure without fever as the main clinical manifestation upon admission. He stated having had contact with stray cats in the past 2 months. The combination of clinical symptoms, echocardiography, and blood mNGS testing confirmed the infection of Bartonella quintana.
Scientific landscape of oxidative stress in sarcopenia: from bibliometric analysis to hotspots review
Authors: Wang Linjie , Guo Dongliang , Huang Yi , Long Pan , Zhang Xin , Bai Ling , Liu Jiancheng , Hu Xiaomin , Pang Rizhao , Gou Xiang
Published: November 2024

Objective

Sarcopenia is a significant healthcare challenge in the aging population. Oxidative stress (OS) is acknowledged to play a pivotal role in the pathological progression of sarcopenia. Numerous studies have demonstrated that mitigating or eliminating OS can ameliorate the pathological manifestations associated with sarcopenia. However, current clinical antioxidant therapies often fall short of anticipated outcomes. This bibliometric analysis aims to delineate prevailing research trends, thematic emphases, focal points, and developmental trajectories within the domain of OS in sarcopenia, while also endeavoring to explore prospective anti-oxidative stress strategies for future clinical interventions.

Methods

Relevant publications were retrieved from the Web of Science (WOS) Core Collection database for the period 2000-2024. Citespace was employed for retrieving and analyzing trends and emerging topics.

Results

In the field of OS in sarcopenia, the number of publications has significantly increased from 2000 to 2024. The United States and China are the primary contributors to global publication output. The most productive research institution is INRAE. The most prolific author is Holly Van Remmen from the United States, while the most frequently cited author is Cruz-Jentoft AJ from Spain. Experimental Gerontology is the journal with the highest volume of published articles, whereas the Journal of Gerontology Series A: Biological Sciences and Medical Sciences holds the record for the highest number of citations. The research keywords in this field can be categorized into eight domains: “Physiology and anatomy”, “Physiological mechanisms”, “Pathology associations”, “Experimental studies”, “Nutrition and metabolism”, “Sports and physical activities”, “Age” and “Oxidation and antioxidation”. Moreover, recent years have seen the emergence of “TNF-α,” “insulin resistance”, “mitochondrial autophagy”, “signal pathways”, and “mechanisms” as focal points in the realm of OS in sarcopenia, encompassing related fundamental research and clinical translation.

Conclusion

This bibliometric and visualization provides a comprehensive analysis of the global research landscape in the field of OS in sarcopenia, identifies priorities, summarizes the current research status and suggests possible future research priorities. In addition, in order to benefit more sarcopenia patients, strengthening cooperation and communication between institutions and research teams is the key to the future development of this field. Given the expectation that research on OS in sarcopenia will remain a prominent area of interest in the future, this article could serve as a valuable resource for scholars seeking to shape future studies through an understanding of influential scholarly contributions and key research findings.

Systematic review registration

https://www.crd.york.ac.uk, identifier CRD42024528628.
Impact of soil legacy on plant–soil feedback in grasses and legumes through beneficial and pathogenic microbiota accumulation
Authors: Idbella Mohamed , Abd-ElGawad Ahmed M. , Chouyia Fatima Ezzahra , Bonanomi Giuliano
Published: November 2024

Plants shape their surrounding soil, influencing subsequent plant growth in a phenomenon known as plant–soil feedback (PSF). This feedback is driven by chemical and microbial legacies. Here, we cultivated six crops from two functional groups, i.e., three grasses (Lolium, Triticum, and Zea) and three legumes (Glycine, Lens, and Medicago), to condition a living soil. Subsequently, the same species were sown as response plants on conspecific and heterospecific soils. We employed high-throughput sequencing in tandem with soil chemistry, including total organic matter, pH, total nitrogen, electrical conductivity, phosphorus, and macro and micro-nutrients. Our results showed that Glycine exhibited the strongest negative PSF, followed by Triticum and Zea, while Lolium displayed low feedback. Conversely, Lens demonstrated robust positive PSF, with Medicago exhibiting slight positive feedback. Soil chemistry significance indicated only higher Cl content in Triticum soil, while Lens displayed higher Zn and Mn contents. Microbial diversity exhibited no significant variations among the six soils. Although conditioning influenced the abundance of functionally important microbial phyla associated with each plant, no specificity was observed between the two functional groups. Moreover, each crop conditioned its soil with a substantial proportion of fungal pathogens. However, co-occurrence analysis revealed a strong negative correlation between all crop’s biomass and fungal pathogens, except Glycine, which exhibited a strong negative correlation with mutualists such as Arthrobacter and Bacillus. This underscores the complexity of predicting PSFs, emphasizing the need for a comprehensive understanding of plant interactions with both pathogens and mutualists, rather than focusing solely on host-specific pathogens.
Matrine regulates autophagy in ileal epithelial cells in a porcine circovirus type 2-infected murine model
Authors: Wang Hong , Sun Na , Sun Panpan , Zhang Hua , Yin Wei , Zheng Xiaozhong , Fan Kuohai , Sun Yaogui , Li Hongquan
Published: November 2024

Introduction

Porcine circovirus type 2 (PCV2) is an important pathogen that causes diarrhea in nursery and fattening pigs, resulting in huge economic losses for commercial pig farms. Protective efficacy of vaccines is compromised by mutations in pathogens. There is an urgent need to articulate the mechanism by which PCV2 destroys the host’s intestinal mucosal barrier and to find effective therapeutic drugs. Increasing attention has been paid to the natural antiviral compounds extracted from traditional Chinese medicines. In the present study, we investigated the role of Matrine in mitigating PCV2-induced intestinal damage and enhancing autophagy as a potential therapeutic strategy in mice.

Methods

A total of 40 female, specific-pathogen-free-grade Kunming mice were randomly divided into four groups with 10 mice in each group: control, PCV2 infection, Matrine treatment (40 mg/kg Matrine), and Ribavirin treatment (40 mg/kg Ribavirin). Except for the control group, all mice were injected intraperitoneally with 0.5 mL 105.4 50% tissue culture infectious dose (TCID50)/mL PCV2.

Results

While attenuating PCV2-induced downregulation of ZO-1 and occludin and restoring intestinal barrier function in a PCV2 Kunming mouse model, treatment with Matrine (40 mg/kg) attenuated ultrastructural damage and improved intestinal morphology. Mechanistically, Matrine reversed PCV2-induced autophagosome accumulation by inhibiting signal transducer and activator of transcription 3 (STAT3) phosphorylation and upregulating Beclin1 protein expression, thus resisting viral hijacking of enterocyte autophagy.

Discussion

Our findings demonstrate that Matrine may be a novel, potential antiviral agent against PCV2 by activating intestine cellular autophagy, which provides a new strategy for host-directed drug discovery.
Impact of low FODMAP sourdough bread on gut microbiota using an in vitro colonic fermentation model
Authors: Koc Fatma , Arendt Elke , Coffey Aidan , Ross R. Paul , Stanton Catherine
Published: November 2024

This study explores the development of whole-grain sourdough bread with reduced FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) content to offer dietary solutions for individuals with irritable bowel syndrome (IBS). Three sourdough breads were prepared using different lactic acid bacteria (LAB) strains including Lactiplantibacillus plantarum FST1.7 (SD-FST1.7), Lacticaseibacillus paracasei R3 (SD-R3), and Pediococcus pentosaceus RYE106 (SD-RYE106). A control sourdough bread was prepared using baker’s yeast (SD-control). In vitro digestion and in vitro colonic fermentation were employed on bread samples with cellulose (negative control) and inulin (positive control), followed by 16S rRNA sequencing and short-chain fatty acid (SCFA) analysis to evaluate the impact on gut microbiota and SCFA levels. Alpha and beta diversity did not reveal any significant differences within the groups following in vitro colonic fermentation (FDR > 0.05). Taxonomic analysis displayed Firmicutes as the predominant phylum across all fecal samples at the end of colonic fermentation. Actinobacteriota was significantly lower in cellulose fermented fecal samples compared to samples fermented with SD-Control (ANCOMBC, FDR = 0.02) and inulin (ANCOMBC, FDR = 0.0001). Fecal samples fermented with inulin had significantly higher Bacteroidota levels compared to those fermented with cellulose (ANCOMBC, FDR =0.002). Acetate levels were higher in fecal samples fermented with SD-FST1.7 compared to those fermented with SD-R3 and SD-RYE106 (p = 0.03 for both). Positive correlations between butyrate and Lachnospira, Agathobacter, and Bifidobacterium were observed, demonstrating the potential of sourdough fermentation to influence gut health and support IBS management.
Efficacy of acupuncture in ameliorating anxiety in Parkinson's disease: a systematic review and meta-analysis with trial sequential analysis
Authors: Wu Zhennan , Liu Chang , Chan Vickie , Wu Xiaofeng , Huang Fan , Guo Zining , Liu Wenhao , Lu Liming , Xu Nenggui
Published: November 2024

Background

Although numerous studies have explored acupuncture for alleviating Parkinson's disease (PD) symptoms, specific methods focusing on reducing anxiety in these patients are lacking. Preliminary research indicates that acupuncture may improve anxiety in patients with Parkinson's; however, high-quality evidence is lacking. Therefore, we conducted a meta-analysis and trial sequential analysis (TSA) to assess the efficacy of acupuncture in managing anxiety symptoms in PD.

Methods

We systematically searched eight databases for randomized controlled trials (RCTs) evaluating the efficacy of acupuncture for the treatment of anxiety in patients with PD. Primary outcomes were measured using the Hamilton Anxiety Scale (HAMA) and the Self-Rating Anxiety Scale (SAS). Secondary outcomes included the Parkinson's Disease Questionnaire-39 (PDQ-39) and the Unified Parkinson's Disease Rating Scale (UPDRS). Risk of bias was assessed using the Cochrane RoB 2.0 tool, and certainty of evidence was assessed using the GRADE system. The Trial Sequential Analysis (TSA) was used to assess the sufficiency of the evidence.

Results

Our meta-analysis included 14 studies. The Manual acupuncture (MA) + routine drug treatment (RDT) group improved more than the RDT alone group. MA was more effective than sham acupuncture. MA+ traditional Chinese medicine (TCM) was also more effective than TCM. Auricular therapy (AT) was not as effective as control therapy (CT). The Electroacupuncture (EA) + routine drug treatment (RDT) group was not as effective as RDT. PDQ-39 and UPDRS subgroup analysis showed that the acupuncture group had better clinical efficacy than CT. The GRADE assessment rated the overall certainty of evidence for anxiety outcomes as low, PDQ-39 as very low and UPDRS as low. TSA results indicate insufficient evidence; further high-quality RCTs are needed to substantiate these findings.

Conclusion

Our analysis suggests that MA combined with RDT may help ameliorate anxiety in PD patients, although the evidence is weak due to low quality RCTs. EA and AT showed no significant effects, highlighting the need for more rigorous studies with better controls and longer follow-up. The potential of acupuncture for PD-related anxiety should be considered with caution until stronger evidence becomes available.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/.
The effectiveness of olfactory training for chronic olfactory disorder following COVID-19: a systematic review
Authors: Treder-Rochna Natalia , Mańkowska Aleksandra , Kujawa Wiktoria , Harciarek Michał
Published: November 2024

Background

Chronic olfactory disorders are some of the most frequent post-COVID-19 presentations. Olfactory training (OT) is currently the most popular method used for treating post-viral olfactory dysfunction (PVOD). We evaluated the effect of olfactory training on the chronic olfactory disorders of patients infected with COVID-19.

Methodology

A systematic literature search was performed per PRISMA guidelines in PubMed, Scopus, Web of Science, EBSCOhost, and the Cochrane Library. Only patients with chronic olfactory disorders of 30 days or more were included. The primary outcome was the olfactory score at the end of follow-up. In all studies, improvement was defined as a positive change over time in the results of objective psychophysical olfactory tests. The most commonly used test was the Sniffin' Sticks. Typically, outcome measures involved comparing the mean olfactory scores. In the Sniffin' Sticks test, an improvement was also indicated by a change of 5.5 points or more in the Threshold, Discrimination, and Identification scores.

Results

Fourteen studies (1.596 participants) were included in this review. Among the included studies, up to 10 were RCTs. Nine studies assessed the combined effects of adjuvant therapy and olfactory training, while five studies assessed only OT.

Conclusions

In our assessment, olfactory training alone produces significant improvements in chronic olfactory dysfunctions. However, a combined therapy approach is essential to achieve more effective outcomes. Integrating olfactory training with adjuvants like CoUltraPEALut, Cerebrolysin, and oral Vitamin A has demonstrated substantial benefits in enhancing post-COVID-19 olfactory function. Strict adherence to the OT protocol and extending the duration of OT to 3 months or more significantly enhance treatment outcomes.
Dispensing of zolpidem and benzodiazepines in Brazilian private pharmacies: a retrospective cohort study from 2014 to 2021
Authors: Carvalho Fabiana , Tonon André Comiran , Hidalgo Maria Paz , Martins Costa Manuela , Mengue Sotero Serrate
Published: November 2024

Objective

The study aimed to evaluate Zolpidem and Benzodiazepines prescription and dispensing data in private pharmacies in Brazil from 2014 to 2021. Methods: This retrospective cohort study was carried out with retrospective open data from the Brazilian Federal Government from January 2014 to August 2021 containing medicines registered in the National Controlled Products Management System (SNGPC).

Results

Between January 2014 and August 2021, a total of 32,441,392 sales of thirteen drugs from the z-drug and benzodiazepine classes used to treat sleep disorders were recorded in Brazil. Throughout the entire period, clonazepam emerged as the most popular drug, accounting for 29.8% of total sales. Alprazolam followed in second place with 20.6% of sales, while zolpidem came in third with 14.4%. The normal-release form of zolpidem was consistently the highest-selling variant during the evaluation period. However, the fast-acting-release form exhibited the most significant growth, indicated by a noticeable upward trend in sales since 2020. In contrast, the extended-release form of zolpidem remained stable over the years.

Conclusion

The increased sales of zolpidem in Brazilian private pharmacies raise concerns about potential misuse and dependence on this drug mainly for the treatment of insomnia. The epidemic of sleeping pills arises in a scenario of expectancy of short-term amelioration of symptoms, with no correspondence in best clinical practice. Education and counseling for both healthcare professionals and the general population are essential to address this growing health concern and ensure the safe and appropriate use of medications for sleep disorders.
EAF2: a tumor suppressor gene with multi-aspect functions
Authors: Ji Wen-Tong , Cui Chun-Guo , Wang Yao
Published: November 2024

Since ELL-associated factor 2 (EAF2) was identified in 1997 as an androgen response gene, it has been of medical and scientific interest. Early studies demonstrated the tumor-suppressing function of EAF2 in the prostate. Sequencing studies indicated an association between EAF2 and several other malignant diseases and multiple physiological processes, such as transcription, apoptosis, embryogenesis, and DNA repair. Further understanding of EAF2 will provide new opportunities and therapeutic approaches for cancers, especially prostate cancer. This narrative review summarizes the existing knowledge of EAF2 and outlines its potential significance. To our knowledge, this is the first review of the role of this novel tumor suppressor gene and its possible functions.