bluuebunny/crossref_metadata_2025 huggingface dataset:
Ethnobotanical Survey of Some Medicinal Plants used in Ikpoba-Okha Local Government Area, Edo State, Nigeria
Authors:   University of Benin, Nigeria, Osayimwen Friday Ekhorutomwen , Osadolor Nosayaba , Okoogua Stainless Obaile
Published: June 2023

Traditional use of plants for medicine has been an agelong practice among different ethnicities of the globe before the advent of modern medicine. A study was conducted among the people of Ikpoba-Okha Local Government Area of Edo State, Nigeria, to find out the ethnomedicinal knowledge of the traditional medical practitioners in the area for the purpose of documenting the available information relating to medicinal plants. Ikpoba-Okha Local Government Area comprise of 73 communities, out of which 32 (44%) communities were selected using stratified random sampling. Ethnobotanical data was collected using closed-end questionnaire, group discussion and guided field walk. A total of 500 questionnaire were administered to 37 local herb sellers, 144 traditional medical practitioner and 318 other local informants. Questionnaires used for the interview was divided into Part A & B; A containing demographic information of respondent and part B contained information on medicinal plant such as plant local name, life form, part of plant used, ailments treated, method of preparation, mode of administration, dosage etc. The data was analyzed using descriptive statistical method. The investigation revealed that 111 plant species belonging to 53 families are used for the prevention and treatment of 80 ailments. 22.64% of the plant species use for medicinal purpose belong to the ‘’Fabaceae’’ family. The most common of traditional medicinal preparation and administration methods were decoction and oral administration among others. The study revealed that the most of the traditional medicine knowledge in the area is still strictly held in secrecy, with the older generation being the major practitioners. This greatly puts the knowledge of the medicine plants at risk of being eroded in the near future and therefore requires an urgent need for more documentations.
Empowering Amazonian Communities: The Importance of Participatory Planning and Local Knowledge in Agroforest Systems
Authors: Pauletto Daniela , Lima Pricila da Silva Ferreira de , Silva Ádria Fernandes da , Sousa Verena Santos de , Oliveira Thiago Gomes de Sousa , Rode Rafael , Almeida Everton Cristo de
Published: June 2023

Agroforestry systems (AFS) represent an alternative production method for family farmers, allowing for the optimization of land use through product diversity and income generation. Considering that the socioeconomic condition of floodplain communities is based on extractive economies and that the implementation of intercropped crops should be done in a participatory and constructive manner, this work aims to report an experience emphasizing the steps and main tools adopted in the planning and establishment of an AFS. The fieldwork was conducted in the community of Ipaupixuna, in the floodplain region of Lake Maic´ a, municipality of Santar´em, Par´ a, Brazil. The actions of this work were concentrated between February and October 2019, as part of the research project ”Floodplains and Riverbanks of the Lower Amazon.” The main tools used in this work were a systemic approach with the community of Ipaupixuna, which sought to understand the environment and its interactions, through various stages such as mapping, workshops, interviews, planning, area preparation, and logistical organization for implementation. The actions and results of the project showed that participatory planning and community knowledge are crucial for the successful establishment of an AFS in communities. It was concluded that the community embraced the intercropping project and showed interest and collaboration in the activities carried out. This work reinforces the need to consider resources and tools for the necessary mapping and development of appropriate agroforestry designs for producers in similar initiatives.
Ageism and Physician Employment Opportunities
Authors: Lazarus Arthur
Published: June 2023

Ageism and age discrimination — stereotyping, prejudice, or discrimination against older adults — are evident in all manner of workplaces, including healthcare. Biases in the hiring and firing of older physicians are usually rooted in concerns about their performance and safety records. Relatively little data, however, is available related to the effect of age on the skills and performance of non-clinical physicians working in industry settings — for example, pharmaceutical and health insurance companies. Managers should be aware of bias “blind spots” in their hiring recommendations.
Assessing athlete readiness using physical, physiological, and perceptual markers
Authors: Janetzki Samuel J. , Bourdon Pitre C. , Burgess Darren J. , Barratt Georgina K. , Bellenger Clint R.
Published: June 2023

This systematic review and meta-analysis evaluated the validity of tests / markers of athletic readiness to predict physical performance in elite team and individual sport athletes. Ovid MEDLINE, Embase, Emcare, Scopus and SPORT Discus databases were searched from inception until 15 March 2023. Included articles examined physiological and psychological tests / markers of athletic readiness prior to a physical performance measure. 165 studies were included in the systematic review and 27 studies included in the meta-analysis. 20 markers / tests of athletic readiness were identified, of which five were meta-analysed. Countermovement jump (CMJ) jump height had a large correlation with improved 10m sprint speed / time (r = 0.69; p = .00), but not maximal velocity (r = 0.46; p = .57). Non-significant correlations were observed for peak power (r = 0.13; p = .87) and jump height (r = 0.70; p = .17) from squat jump, and 10m sprint speed / time. CMJ jump height (r = 0.38; p = .41) and salivary cortisol (r = -0.01; p = .99) did not correlate with total distance. Sub-maximal exercise heart rate (r = -0.65; p = .47) and heart rate variability (r = 0.66; p = .31) did not correlate with Yo-Yo Intermittent Recovery Test 1 performance. No correlation was observed between blood C-reactive protein and competition load (r = 0.33; p = .89). CMJ jump height can predict sprint and acceleration qualities in elite athletes. The validity of the other readiness tests / markers meta-analysed warrants further investigation.
Projeto de uma miniusina piloto de baixo custo para produção de biodiesel a partir do óleo de cozinha usado
Authors: Ravaglia Patrick Marques , Corrente Thayane Silva , Chagas Marcelo , Zanelato Erick Bernabé
Published: June 2023

A energia é um dos fatores socioeconômicos mais importantes no desenvolvimento humano, e grande parte da matriz energética atual provém de fontes não renováveis. Consequentemente, geram-se grandes problemas, como elevado crescimento da poluição e crises energéticas. Diante desse cenário, os biocombustíveis estão se mostrando uma alternativa atraente pelo seu desempenho e a possibilidade de uso de resíduos como fonte de matéria prima, como o óleo de cozinha usado, que é um grande poluidor devido ao seu descarte, geralmente, irregular. Dentre os diferentes tipos de biocombustíveis, está o biodiesel, o qual pode ser conceituado como um combustível renovável proveniente comumente da reação de transesterificação. No projeto da miniusina piloto foram considerados diversos fatores que estão diretamente relacionados com as partes técnica e econômica do processo de produção do biodiesel, como materiais a serem utilizados, temperatura, tempo de operação, reagentes e proporções da reação química. Muitas pesquisas apontam altos níveis de conversão dos triglicerídeos (óleo) para éster (biodiesel) utilizando hidróxido de potássio e etanol como reagentes, aquecidos a 60 ºC durante 50 minutos. Após fazer um estudo acerta dos elementos necessários para a usina piloto, visando baixar o custo, são apresentados os projetos e os elementos que compõem sua produção, com tubulações, tanques, válvulas, estrutura de sustentação, termostatos e um motor. O gasto total com equipamento foi de em média R$2.500,00 e o custo por batelada (reagentes e energia elétrica) foi em média R$1,726 por litro.
OPTIMIZING PROACTIVE COLLABORATIVE AND COOPERATIVE RELATIONSHIPS BETWEEN FOOD SUPPLIERS AND RESTAURANTS
Authors:   University of Transilvania from Brașov, Romania, Gruia Romulus ,   Academy of the Romanian Scientists, Romania,   Academy of Agricultural and Forestry Sciences ",   Gheorghe Ionescu-Sisesti",   , Romania,   National Institute of Economics Research, Romanian Academy, Romania, Gaceu Liviu ,   University of Transilvania from Brașov, Romania; Academy of the Romanian Scientists, Romania; National Institute of Economics Research, Romanian Academy, Romania
Published: June 2023

Currently, agri-gastronomy and the ”tourist-catering” subsector have an increasingly well-defined role in the realization and commercialization of goods and services offered in terms of food quality and systemic efficiency. This study aims to identify that tourist destinations and many local communities offer a variety of gastronomic products and services and that the supply sector in semi-structured and still needs improvements in quality, safety and a wider commercial network. The paper highlights the need for suppliers to reinvent themselves and create new market opportunities to benefit from rapid growth in key sectors of the integrated food system. A number of relational solutions are analyzed with the potential to generate an authentic cuisine based on tradition and sustainability, with strong elements of originality. Consequently, it is highlighted that the consolidated and optimized relationships in the producer-processor network may be able to ensure diversified and quality local products, which gives restaurants a competitive advantage in the post-pandemic recovery.
Romanian mountain entrepreneurship from a statistical perspective: EVIDENCES on commercial and logistics sectors
Authors:   CBM International University & University of Oradea, Romania, COVACI Brîndușa , BREJEA Radu ,   University of Oradea, Romania; Academy of Romanian Scientists, Romania, CONSTANTIN Marian ,   Academy of Romanian Scientists, Romania, COVACI Mihai ,   CBM International University & Hyperion University, Romania
Published: June 2023

The paper aims to replace in the Civil Society Organizations in Romania the way that has been performed so far, as for them to acquire the transformation in order to achieve superior, modern, sustainable results and progress in their development.
AVALIAÇÃO E MANEJO DA DOR NA UNIDADE DE TERAPIA INTENSIVA
Authors: Tavares Cícera Luana Cruz , Pinheiro Isabelly de Oliveira , Brito Marcella Prado Araujo , Cesário Bruna Kerolayni Leite , Cruz Allana Maria Garcia Sampaio , Fernandes Camila Grangeiro , De Oliveira Yasmin Neri Duarte
Published: June 2023

Pacientes submetidos a internação em unidades de terapia intensiva (UTI) são submetidos a procedimentos invasivos, dolorosos e desconfortáveis e experienciam o conceito de dor total que aborda as dimensões do sofrimento humano (físico, mental, social e espiritual). Para aliviar o sofrimento e garantir a dignidade do indivíduo alguns procedimentos farmacológicos e não-farmacológicos são utilizados.   Foi realizada uma busca eletrônica por artigos publicados em periódicos indexados através da base de dados PubMed, as recomendações metodológicas foram seguidas para esse tipo de estudo de revisão utilizando o protocolo PRISMA. Foram admitidos estudos publicados entre janeiro de 2017 e novembro de 2022. Com o avanço da medicina humanizada e do entendimento da complexidade de cada indivíduo, o tratamento farmacológico e não farmacológico para o alívio da dor passou a ser utilizado para minimizar o sofrimento e fornecer maior qualidade de vida durante a internação.
ATUAÇÃO DA FISIOTERAPIA NO PÓS-OPERATÓRIO DE FRATURA DE FÊMUR EM IDOSOS
Authors: Torres Sabrina Bezerra , Alves Ádila Ferreira , Cruz Adyla Fernanda da Silva , da Silva Lívia Maria , De Lira Monyk Drielly Gomes , Barros Nyelle Nunes , Araújo Vitória Celice Campos , Cabral Rosangela de Melo
Published: June 2023

O envelhecimento populacional é um fenômeno que vem ocorrendo em todo o mundo devido ao aumento da expectativa de vida e à diminuição da taxa de fecundidade. Isso tem levado a um aumento do número de pessoas idosas, o que traz desafios para os sistemas de saúde e para a sociedade em geral. As alterações fisiológicas que ocorrem durante o envelhecimento são complexas e afetam diversos sistemas do corpo, incluindo o cardiovascular, o respiratório, o muscular, o esquelético e o nervoso Tais mudanças culminam para o aumento do risco de quedas, fator que está diretamente ligado à incidência das fraturas, que em sua grande maioria são no fêmur. A atuação do fisioterapeuta estará voltada para a execução das atividades diárias do idoso após o acidente, consequentemente melhorando sua funcionalidade. Verificar os aspectos do profissional fisioterapeuta com significância para a reabilitação pós-operatória de idosos submetidos a grande cirurgia de fêmur. Foram sumarizados 5 artigos que abordaram a importância da especialidade de fisioterapia. Diante dos resultados, a avaliação clínica inicial torna-se de extrema importância, além de achados radiológicos de consolidação de fratura, que irão determinar a melhora ou piora na cicatrização do paciente. Conclui-se que a fisioterapia desempenha um papel fundamental no pós-operatório de fratura de fêmur em idosos, contribuindo, sobretudo para a melhoria na execução das atividades diárias, como melhorando sua funcionalidade, pois o fortalecimento muscular, a descarga de peso efetiva e o treino de equilíbrio, por exemplo, são fundamentais no processo de recuperação.
Yedinci Sınıf Fen Bilimleri Ders Kitaplarında Yer Alan Fiziksel Olaylar Konu Alanı Sorularının Üst Düzey Düşünme Becerileri Açısından İncelenmesi
Authors: EROL Yasemin , EZBERCİ ÇEVİK Ebru
Published: June 2023

Bu çalışmada Üst Düzey Düşünme Becerileri (ÜDDB) açısından yedinci sınıf fen bilimleri ders kitaplarında yer alan fiziksel olaylar konu alanı sorularının incelenmesi amaçlanmıştır. Bu bağlamda ÜDDB’den analitik düşünme, eleştirel düşünme, problem çözme, yaratıcı düşünme ve karar verme becerileri araştırmaya dahil edilmiştir. Araştırma nitel bir çalışma olup, araştırma desenlerinden durum çalışması modeline göre hazırlanmıştır. Araştırmada veri kaynağı olarak biri MEB Yayınevi, diğeri ise Eğitim Bilişim Ağında (EBA) yayınlanmış özel bir yayınevine ait fen bilimleri ders kitapları kullanılmıştır. Verilerin analizinde betimsel analiz kullanılmıştır. Verilerin analizi sonucunda, ders kitaplarında yer alan soruların en fazla analitik düşünme ve eleştirel düşünme becerilerine yönelik, en az yaratıcı düşünme becerisine yönelik olduğu tespit edilmiştir. Elde edilen bulgular doğrultusunda, ders kitaplarındaki soruların yaratıcı düşünme ve karar verme becerileri açısından geliştirilmesi gerektiği ve tüm becerilerin ders kitaplarında eşit bir şekilde dağıtılması gerektiğine yönelik sonuçlara ulaşılarak ilgili önerilerde bulunulmuştur.
Cómo surgen las nuevas iglesias
Authors: Rode Daniel Julio
Published: June 2023

La obra de Rode es el fruto de las experiencias de cuarenta años como pastor, profesor y fundador de iglesias.El material está enriquecido con la historia latinoamericana de lafundación de iglesias y las vivencias de cientos de pastores y alumnos de los posgrados donde el autor enseñó. Tal condición la convierte en una obra relevante para el contexto latinoamericano interdenominacional.Los ejemplos tomados de la realidad le confieren un valor práctico para los miembros y líderes cristianos interesados en fundar iglesias.El libro expone algunos ejemplos de cómo se iniciaron diversas iglesias cristianas en Latinoamérica. Presenta la base teológica de las “comunidades religiosas pequeñas” en el Antiguo y el Nuevo Testamento. Reflexiona sobre el potencial de los jóvenes para fundar iglesias, especialmente en las ciudades. Considera la pregunta “¿por qué fundar iglesias?” y trata las objeciones y razones para plantar iglesias. Finalmente, con diversos modelosprácticos, el autor muestra cómo hacerlo.
Effect of Microcredit on Welfare of Rural Households in Oyo State, Nigeria
Authors: Dada Obadimu Olajumoke , Yusuf Sulaiman Adesina , Yusuf Wasiu Akintunde , Olusegun Obadimu Olusola , Olatunji Olajide Oyebisi , James Fasakin Idowu
Published: June 2023

The impact of microcredit on the livelihoods of poor rural households and its contribution to the socioeconomic development of the poor cannot be underestimated. This study investigated the effect of microcredit on rural households irrespective of the enterprises engaged. Primary data was collected through semi-structured questionnaires. A total of one hundred and fifty rural household heads were interviewed using a multi-stage sampling technique to select the respondents and only 134 (89.33%) questionnaires were used for the analysis. The data collected were analyzed using descriptive statistics, Mean Per Capita Household Expenditure (MPCHE), and ordered logistic regression models. The results of findings showed that 57.46% of the respondents were males, 82.84% were married and 67.91% were literate. The mean of age, household size, and years of formal education were 38.9years, 6.22, and 9.59years respectively. The findings further revealed that household size (Pα0.5), years of formal education (Pα0.1), years of experience (Pα0.1), the interest charged on the credit (Pα0.0a 5), the time lag of credit delivery (Pα0.05), payback period (Pα0.01), and distance to credit source (Pα0.1) were significant to microcredit access in the study area. The ordered logit result revealed that distance to credit source and household total expenditure were significant to welfare level at Pα0.1 and Pα0.01 respectively however, household size and amount borrowed are negatively correlated to welfare level and significant at Pα0.01 and Pα0.1 respectively. The Mean Per Capita Household Expenditure (MPCHE) was N7064.14 with a welfare line of N709.36 and the welfare categories are low (18.66%), average (41.04%), and high (40.30%). It is therefore recommended that the payback period should be extended to allow ease of repayment with low-interest rates and the means of accessing credit should be improved so that more households could benefit. Also, the government should intensify efforts toward education beyond the primary level among rural households.
Bankacılıkta Dijitalleşmenin Etkileri ve Türkiye’deki Analizi
Authors: KOCATÜRK Yaren
Published: June 2023

Finansal sektörlerden bankacılık sektörü dijitalleşmeyle en hızlı gelişme gösteren sektörlerden biri olmuştur. Dijitalleşme sayesinde bankalar sadece şube kanalından değil, mobil ve internet bankacılığı ile hizmetlerin tümünü sunabilir hale gelmiştir. Müşteriler akıllı telefon, bilgisayar ve tablet üzerinden zaman ve mekan sınırı olmadan istedikleri her yerde işlem yapma imkanı bulmaktadırlar. Dijitalleşme maliyet avantajı, gelir artışı, hızlı işlem yapma, işlem takibi ve işlem çeşitliliği gibi bir çok avantajı beraberinde getirmiştir. Dijital bankacılık sistemi büyük ve küçük ölçekli bankaları yakın seviyeye getirmeye zemin hazırlamıştır. Teknolojik altyapısını sürekli geliştirip, tecrübe ve sistem yönetimi öne ile çıkan bankalar avantajlı olmaktadır. Bu çalışmada, mobil ve internet bankacılığı işlemleri, banka şube sayısı ve çalışan sayılarına ilişkin güncel verilere bakılarak dijital bankacılığın avantajlarını vurgulamak ve bankacılık sektörünün nasıl etkilendiğini ortaya koymak amaçlanmaktadır.
Plataformas flexíveis para experimentação: o caminho para atender as novas demandas de experimentação científica em TICs
Authors: Mondin Leandro , Dias Gustavo
Published: June 2023

Neste artigo são discutidos os principais desafios na oferta de ambientes para experimentação científica (Testbeds) em TICs, cujas demandas têm se caracterizado pela crescente necessidade de ensaios mais heterogêneos e complexos. A busca pelo equilíbrio entre oferecer uma plataforma para experimentação flexíveis o suficiente para acolher pesquisas interdisciplinares e, ainda assim, que possibilite experimentações especializadas têm sido a abordagem adotada pelo Serviço de Testbeds RNP. Os autores detalham neste trabalho as iniciativas adotadas pela RNP com o propósito de buscar este equilíbrio e expandir o escopo de atendimento das infraestruturas de experimentação disponíveis.
Information
Authors: Hjørland Birger
Published: June 2023

This article presents a brief history of the term “information” and its different meanings, which are both important and difficult because the different meanings of the term imply whole theories of knowledge. The article further considers the relation between “information” and the concepts “matter and energy”, “data”, “sign and meaning”, “knowledge” and “communication”. It presents and analyses the influence of information in information studies and knowledge organization and contains a presentation and critical analysis of some compound terms such as “information need”, “information overload” and “information retrieval”, which illuminate the use of the term information in information studies. An appendix provides a chronological list of definitions of information.
The Effect of Al2O3 Concentration in Annular Fuels for a Typical VVER-1000 Core
Authors: Ghazanfari Valiyollah
Published: June 2023

In this study, the effect of Al2O3 with various volume percentages in annular fuels for a typical VVER-1000 core is investigated. CFD is used to simulate the fuel rod. The results of the present study are compared with those of other published studies. Furthermore, the mentioned analytical methods are validated by comparing the final safety analysis report (FSAR). By comparing the results, it was found that the results are in good agreement with other studies. The results show that using annular fuel instead of solid fuel in the core of the reactor will increase the security and efficiency of the nuclear power plant. By increasing the volumetric concentration of nanofluid from 0.1 to 0.2, the rate in decrease of the peak temperature in the central fuel increases from 9% to 13%. Moreover, the clad temperature decreases from 626 K to 620 K (the clad temperature with pure water is 635 K).
Estimating the Calorific Value and Potential of Electrical Energy Recovery of Organic Fraction of Municipal Solid Waste through Empirically Equations and Theoretically Way
Authors: Made Gunamantha
Published: June 2023

This chapter aimed to estimate the calorific value and potential of electrical energy that can be generated from the organic fraction of municipal solid waste through mathematical models, bioconversion, and thermochemical approach. The calorific values were calculated using the empirical relationship between higher heating value and ultimate analysis data, stoichiometric manner, and thermochemistry concept. The potential of electrical energy that can be produced was calculated based on literature data on the specified power plant. The result showed that the calorific value and potential of electrical energy recovery of the thermochemical approach are higher than others.
Cyanobacteria as the Source of Antioxidants
Authors: Tyagi Rashi , Kumar Singh Pankaj , Tiwari Archana
Published: June 2023

The present-day scenario in the health sector calls for alternative medicine sources with no risk of resistance, effective in the mode of action, and eco-friendly. Cyanobacteria are microbial factories for a wide range of products. They are reservoirs of bioactive compounds which have the potential to act as precursors of novel drug molecules. A plethora of algae have been documented for their therapeutic abilities in treating diseases. A plethora of antioxidative compounds along with enzymes are present in cyanobacteria, possessing applications in nutraceuticals and cosmeceuticals, which is quite evident from the products available in the market. This chapter highlights the significant leads in the area of cyanobacteria-based antioxidants. A sustainable approach to envisaging cyanobacteria as competent antioxidants can open new doors in prevention, treatment, and control of a plethora of diseases.
Essential Role of Symbiotic Microorganisms Supporting Forests in East Asia under Changing Environment
Authors: Wang Yannan , Qu Laiye , Tamai Yutaka , Watanabe Toshihiro , Koike Takayoshi
Published: June 2023

Regeneration success of forests is strongly dependent on symbiotic microorganisms, that is, arbuscular mycorrhiza (AM) and ectomycorrhiza (ECM). In the northeastern part of Asia, larch and birch are used as timber resources, and in the south, fir, cedar, cypress, and oak are used as timber resources. Planted forests have reached the time of harvesting and/or thinning, and after the forestry practices, it is expected that they will become mixed forests equipped with resistance to weather damage; that is, drought, heat, typhoons, etc. On the other hand, the physical production environment has changed greatly, therefore, we investigated the growth of the major trees and the role of mycorrhizal fungi in the northeastern Asia. Elevated O3 decreased growth, colonization rates of ECM, and the biodiversity; however, elevated CO2 moderated or increased them in larch. Except for disease of rot and damping off, we discuss wise use of symbiotic microbe in far East Asia.
The Role of the Gluten-Free Diet in the Development of Malignancies in Celiac Disease
Authors: Botosso Maiara , Damasceno Renatta , Farage Priscila
Published: June 2023

Celiac disease (CD) is an autoimmune disorder that can lead to serious health consequences, including cancer. The gluten-free diet (GFD) is the primary treatment for CD and has been shown to lead to clinical remission of the disease. However, the effect of the GFD on cancer development in CD patients is not well understood. This narrative review analyzed observational studies investigating the association between cancer development and adherence to the GFD in CD patients. The most common cancer identified was non-Hodgkin’s lymphoma, followed by others such as colon carcinoma and thyroid cancer. Late diagnosis, type of cancer, and type of CD were factors relevant to the protective role of the GFD. However, there is still no consensus in the scientific literature regarding the GFD’s role in cancer development in CD. While some studies suggest a protective role, others have not identified an association between the GFD and cancer. More research is needed to understand the relationship between the GFD and cancer development in CD patients. Nonetheless, the GFD is essential for the clinical, serological, and histological remission of CD and improved quality of life.
Perspective Chapter: Tissue Specificity of Exosomes and Their Prospects as a Drug Delivery System
Authors: Petkevich Alisa , Abramov Aleksandr , Pospelov Vadim
Published: June 2023

This chapter reviewed the various sources of exosomes and their characteristics. Exosomes, which in the context of the proposed chapter are the synonym for extracellular vesicles up to 200 nm, play a pivotal role in cell to cell communication thus leading to the involvement of exosomes in inflammation and cancer development. This brings exosomes to the forefront of promising markers of a sub-clinical stage of the disease, which makes identifying exosome’s source and destination one of the main goals in exosome research. However, due to some biogenesis features and technological difficulties, which are discussed further, identification of a certain exosome’s address, or its specificity for a certain tissue or cell type, becomes a non-trivial task. The chapter covers the following questions: some of the main barriers on the way of testing tissue specificity hypothesis of exosomes, exosomes from synovial fluid and CSF and their features, exosomes from mesenchymal stem cells (MSCs) of different origins, and some membrane and cargo exosomal markers for tissue specificity and the prospect of exosomes as a drug delivery approach.
Skin Care Nanocosmetics
Authors: Scherer Santos Júlia , Sousa Ponciano Carolina , Nogueira Barradas Thaís , Pascoal Costa Mirsiane , Diniz Tavares Guilherme
Published: June 2023

The improvement of stability, solubility, spreadability and skin penetration of cosmetics as well as the reduction of oxidation may be achieved by nanocarriers. In that regard, many cosmetic industries have launched nanocosmetics due to their performance improvement. Sunscreens, moisturizers and anti-aging products based on nanotechnology are available worldwide. In addition, vegetable extracts loaded into nanocarriers have also been employed as a strategy to increase their skin penetration. In this chapter, the main contributions of polymeric nanocarriers, lipid nanocarriers and vesicular nanocarriers to skin care cosmetics were approached.
Biofiction and History: A Comparative Reading of the Lives of Captain Cook, Sultan Selim III, and Kuchuk Huseyin Pasha
Authors: Bakay Gönül
Published: June 2023

Biofiction is a hybrid literary genre that appropriates historical lives and molds them into the subject of fiction; it uses historical characters rather than representing them. This literary genre, which has stimulated a vast array of reactions over the past few decades, is not a branch of history or biography. Anna Enquist’s 2005 novel The Homecoming is a successful example of biofiction that revolves around the illustrious life of Thomas Cook but tells the story from the perspective of his wife Elizabeth Cook. Through the reconstructed voices of these historical figures, the reader is offered alternative perspectives into their lives as well as into the British Empire in the eighteenth century. Stanford Shaw’s critically acclaimed Between Old and New (1971), on the other hand, is a history book that aims to offer a factual representation of the eighteenth-century Ottoman Empire, particularly the reign of Sultan Selim III. This chapter aims to examine the interesting parallels and differences in the lives of these historical figures as depicted in a work of biofiction and a history book and show how differences in genre implicate the portrayal of historical figures.
Chlamydia trachomatis Infection in Women
Authors: Surmen Usta Sibel
Published: June 2023

Chlamydia trachomatis infections are the most commonly encountered sexually transmitted disease worldwide. Multiple partners and failure to use condoms are the well-defined risk factors. A significant proportion of females are asymptomatic. Treatment modalities such as a single 1-g dose of azithromycin orally, or doxycycline 100 mg twice per day for 7 days have been widely used for noncomplicated genital infections. However, untreated C. trachomatis infections can cause late complications, including salpingitis, ectopic pregnancy, and female factor infertility. Screening is a possible strategy to control asymptomatic cases and women at increased risk of infection in a proportional group of women.
Endoplasmic Reticulum Involvement in Heart Injury: An Overview
Authors: Favero Gaia , Bonomini Francesca , Gianò Marzia , Rezzani Rita
Published: June 2023

The Endoplasmic Reticulum (ER) is a multifunctional organelle present in the cytoplasm of the eukaryotic cells. It is involved in many aspects of cellular physiology and it presents important interaction with other cellular organelles. Different physiological and/or pathological factors may alter ER morphology and homeostasis, resulting in the accumulation of a large number of unfolded/misfolded proteins in the ER lumen and so inducing ER stress. Alterations in ER have been found to be related to different disorders. In particular, ER stress is implicated in the development and progression of various heart injuries, such as myocardial infarction, ischemia/reperfusion, heart failure, diabetic cardiomyopathy, arrhythmias and cardiotoxicity. Furthermore, the efficiency to counteract the ER stress declines significantly during the physiopathological aging process. In this chapter, we present the correlation between the ER and cardiac injury focusing mainly on the aging process and then we report a brief overview of the potential involvement of some bioactive molecules as preventive/therapeutic compounds that can contrast heart disorders through ER modulation.
Urban Bus Network Electrification
Authors: Földes Dávid , Csonka Bálint , Ákos Szilassy Péter
Published: June 2023

Electric busses are spreading in cities in hope of mitigating local air pollution. Currently, battery electric busses are more expensive and require novel operational methods to optimize their use (e.g., applying daytime charging, and operating trolleybuses). Despite these, the electrification of urban busses is usually ad-hoc, preliminary planning is superficial, and does not consider the relationships among bus lines. This chapter introduces a method regarding charging infrastructure planning, electric bus type selection, and cost estimation. Based on the characteristics of the vehicle, charging infrastructure, bus service (lines, timetable, etc.), and energy consumption, a line-group optimization is introduced, which is the main novelty. The method was applied in a case study considering static terminal and dynamic catenary charging. The results help operators to boost the electrification of the urban bus network.
The Role of CA19-9 and CA125 in Differentiation of Ovarian Dermoid Cyst and Ovarian Malignancy: A Case-Control Study
Authors: Shamshiri Khamene Sima , Mohammad Khawajah Izat , Mahboobipour Amir Ali , Ataei Jafari Zahra , Feizabad Elham , Adabi Khadijeh , Rezaei Zahra
Published: June 2023

Background: An ovarian dermoid cyst is one of the most prevalent benign tumors in women of reproductive age. They can get complicated or be mistaken for malignant tumors. Most of the time, their pathology will not be discovered until after surgery. Objectives: Finding the role of CA19-9 and CA125 tumor markers in diagnosing the dermoid cyst before surgery and distinguishing it from the malignant type. Methods: A case-control study was conducted on all cases of dermoid cysts and malignant tumors (both diagnosed by pathology) from 2019 to 2021. Required information such as age, level of tumor markers, size, and whether it is unilateral or bilateral were extracted, and the tumor marker levels were analyzed in benign and malignant groups. Results: In this study, 95 cases of ovarian cysts and 85 control of malignant ovarian tumors were included. The mean level of CA19-9 and CA125 in the patients with dermoid cysts was 32.26 ± 5.45 units/mL and 31.37 ± 4.77 units/mL, respectively. In the malignant ovarian tumor group, the average level of CA19-9 and CA125 was equal to 9.56 ± 3.54 units/mL and 233.79 ± 54.57 units/mL, respectively. CA19-9 level was significantly higher in the dermoid cyst group (P-value < 0.001). CA125 level was significantly elevated among the malignant group (P-value < 0.001). It was observed that there was a significant relationship between the level of CA19-9 with the size of the cyst and the level of CA125 with the age of the patients. No significant relationship was found between the level of tumor markers and whether they were unilateral or bilateral. Conclusions: Regarding the correlation between the cyst size and CA19-9 in the comparison of the two groups, this tumor marker may be a suitable diagnostic marker in benign ovarian cysts along with ultrasound.
Effects of Komouni Formulation (Herbal Product of Persian Medicine) With a Low-Calorie Diet on Cardiometabolic Risk Factors in Overweight and Obese Women: A Triple-Blinded Randomized Clinical Trial
Authors: Aghabeiglooei Zahra , Namazi Nazli , Karimi Mehrdad , Soleymani Samaneh , Ayati Mohammad Hossein , Rezaeizadeh Hossein
Published: June 2023

Background: The prevalence of obesity has almost tripled since 1975, and obesity places a heavy economic burden on healthcare systems. There is a high tendency to use a variety of complementary medicine modalities for weight management among obese patients. Persian Medicine is an ancient medical school practiced for thousands of years in Iran. Found in reliable Iranian traditional resources, Komouni formulation (KF) is a compound medicine that can be effective in the treatment of obesity. It comprises black caraway (Bunium persicum Boiss.), anise (Pimpinella anisum L.), fennel (Foeniculum vulgare Miller), and ajwain (Trachyspemum ammi L.) Objectives: This study aimed to determine the effects of KF on anthropometric indices and metabolic parameters in overweight and obese women. Methods: This triple-blinded randomized controlled clinical trial was performed on 70 overweight or obese women aged 20 - 40 years, with a body mass index (BMI) of 25 - 34.9 kg/m2. The subjects were randomly divided into two groups (each group n = 35) to receive a calorie-restricted diet with 2 g/day (500 mg 30 minutes before breakfast, 1000 mg 30 minutes before lunch, and 500 mg 30 minutes before dinner) KF or placebo for 8 weeks. Anthropometric indices, food intake, and biochemical parameters were measured at baseline and after the intervention. Results: A total of 60 women (intervention = 30; placebo = 30) completed the trial. After the intervention, the KF group experienced a significant reduction in weight (-4.8 vs. -3.2 kg; P = 0.0001), BMI (-1.8 vs. -0.79 kg/m2; P = 0.0001), waist circumference (-5.28 vs. -3.20 cm; P = 0.004), hip circumference (-0.018 vs. -0.008 cm; P = 0.047), fasting blood sugar (-5.6 vs. 0.33; P = 0.025), and low-density lipoprotein (-11.7 vs. 6.7; P = 0.0001), compared to the placebo group. None of the patients in the intervention and placebo groups reported any side effects. Conclusions: Using KF, along with a calorie-restricted diet, can reduce cardiometabolic risk factors in overweight and obese women. However, further studies are needed to elucidate the efficacy of KF as a complementary therapy in obesity.
Spinoza’s Model of God: Pantheism or Panentheism?
Authors: Petrufová Joppová Michaela
Published: June 2023

The philosophical God of Spinoza is branded as a pantheistic God so often that, regarding at least Western philosophy and philosophical commentaries, Spinozism seems to be practically synonymous with pantheism. Since the times of German idealism, there have also been attempts at a panentheistic reading, which are still alive to this day. The article analyses both theological models in their core claims to adequately qualify Spinoza’s theological system while considering the established levels of philosophical-theological interpretation. By identifying systemic pantheism and essentialist panentheism in his system, it is argued that both accounts or readings of Spinoza’s theory might be correct in their own way, provided that the models behind them are correctly applied to their respective levels of thought.
The Social, Therapeutic and Didactic Dimension of Shame in Seneca’s Thinking
Authors: Fraňo Peter , Novosád Dominik
Published: June 2023

This paper analyses the problem of shame in the thinking of Lucius Annaeus Seneca. The authors examine this problem primarily in two contexts. The first, social meaning, understands shame as an emotion that appears during a conflict between a person’s “self” and social norms. Seneca mainly tackles this question concerning providing “benefits” (beneficia) in his On Benefits and eighty-first letter of Moral Epistles. The second therapeutic and didactic meaning utilises shame as an instrument to manage some illnesses of the mind (for example, anger). Moreover, to educate a “Stoic disciple” (proficiens), deliberate exposure to shame in public marks one of the important techniques to near the perfect ideal of “the wise man” (sapiens) and to prepare oneself for service in public office. Especially in Moral Epistles, we find a detailed description of this didactic approach and the limiting factors to using this technique.
Exploring the Road of Digital Transformation of Agricultural Marketing Based on the Perspective of Platform Economy
Authors: Chen Jiaxian , Zhang Yu , Zhang Rixin
Published: June 2023

In order to meet the trend of digital transformation and build a marketing system for agricultural products in the form of platform economy, this paper adopts the literature research method to analyze the coupling of the two concepts of platform economy and agricultural products marketing under the framework of digital transformation, and explain the immaturity of marketing subjects, non-standardized marketing channels, unsuitable logistics system, unsuitable marketing products and unclear marketing rules under the current digital transformation mode of agricultural products marketing. The problems of quality assurance and unclear marketing rules. As a result, this paper puts forward policy suggestions, namely, taking the government as the leader, actively exploring new thinking, new ideas and new roads for digital transformation of agricultural products on the basis of improving the legal system, and building a standardized, extensive and innovative Internet agricultural products marketing platform by strengthening the training for relevant practitioners.
ملامح توظيف الفضاء السيبراني في عالمنا المعاصر (الحرب الروسية – الأوكرانية انموذجا)
Authors: علي حسين حميد  , انغام عادي حبيب
Published: June 2023

لم يقتصر تأثير اختراق الثورة التكنولوجية مجالات الحياة المختلفة على التفاعلات السياسية والاقتصادية والمجتمعية للدول والافراد، بل امتدت لخلق ساحة جديدة من الحروب غير التقليدية، بعيدا عن ساحات البر والبحر والجو، الا وهي ساحة الفضاء السيبراني التي توافرت فيها عوامل عديدة حفزت الفواعل الدولية وغير الدولية على استخدامها كإحدى أدوات التنافس والهيمنة والصراع والإرهاب غير التقليدي، لدرجة قد تنقل العالم من الهجمات الالكترونية المختلفة الى "حرب سيبرانية" Cyber War.

تعد روسيا من أوائل الدول التي استغلت الفضاء السيبراني في المجال العسكري، اذ اهتمت بتطوير وزيادة قدراتها الهجومية في هذا المجال منذ عام 1998، وتعتمد الاستراتيجية الروسية في نزاعها مع أوكرانيا على الأسلحة الالكترونية الهجومية باعتبارها انها قوة مضاعفة في الحروب، بمعنى انها تزيد من القدرات القتالية للدولة اذا ما استخدمت الى جانب قدرات عسكرية أخرى، كما تعتمد هذه الاستراتيجية على محاولة تعطيل البنية التحتية المعلوماتية للخصم والاتصالات العسكرية والمدنية له قبل الشروع في العمليات العسكرية.
Collective Responsibility as Resistance to White Supremacy
Authors: Adelsberg Geoffrey ,   Philosophy Documentation Center
Published: June 2023

This article offers a model of collective responsibility that arises out of group implication in the persistent injustices of racism and colonialism. It engages with a case study of Jewish refugees who arrived in the Americas in the aftermath of the 1492 Spanish Edict of Expulsion. There, it identifies a strategy of survival grounded in identification with white Christians at the top of the colonial hierarchy and disidentification with Black and Native peoples at the bottom. This identification yielded benefits for colonial Jews and those (the author included) who inherit their place in the colonial racial hierarchy. These benefits were at the expense of Black and Native peoples in the Americas. The article highlights the relational harms—to others and themselves—inherent in group complicity with white supremacy. It concludes by outlining the forms of collective responsibility that could counteract these harms and create relationality beyond white supremacy.
Filosofia da educação e desenvolvimento da pessoa humana por meio da construção de conceitos éticos
Authors: Soares Filomena Maria Rates , Costa Lins Maria Judith Sucupira
Published: June 2023

Esse artigo resgata a formação moral e ética para transformação da pessoa por meio das virtudes e a prepara para lidar com as emoções. Levantamos a hipótese de que somos movidos pelas emoções e precisamos investir na formação da pessoa por meio da educação das virtudes para sermos capazes de construir uma sociedade de pessoas felizes e justas. O objetivo é levar à reflexão sobre educação, conceito de pessoa e construção dos valores éticos na formação humana baseados na hermenêutica de Paul Ricoeur (2008) que nos permite entender os conceitos selecionados. O artigo levanta duas questões: identificar até que ponto a educação por meio das virtudes transforma a pessoa e porque é necessário compreender o conceito de pessoa. Fundamenta-se em Aristóteles (a.C. IV, 1999), Maritain (1959) Mounier (1964) e Sucupira Costa Lins (2014). Esses autores oferecem suporte para nosso objetivo pela preocupação com a formação da pessoa por meio das virtudes.
 
Palavras-chave: Educação Filosófica. Conceito de pessoa. Formação humana. Educação Integral.
Práticas pedagógicas críticas no Ensino Superior: Educação Emancipadora em curso de Bacharelado de Ciências Contábeis
Authors: Mineiro Márcia , D'Ávila Cristina
Published: June 2023

Este artigo resulta de pesquisa bibliográfica e reflexão sistemática sobre uma prática pedagógica no Ensino Superior de apresentação da Educação Emancipadora a futuros bacharéis de Ciências Contábeis que atuarão como professores. Teve como objetivos: levantar compreensões conceituais sobre a Educação Emancipadora; e identificar entendimentos da importância e possíveis efeitos da Educação Emancipadora na formação docente inicial de prováveis bacharéis-professores. Com cunho exploratório, pautou-se na abordagem metodológica qualitativa, pelo paradigma interacionista. Procedimentalmente, além da análise sobre dados conceituais provindos da pesquisa bibliográfica, apresenta relatos produzidos pelos estudantes em mural digital e compreendidos pela análise de conteúdo com duas categorias a priori. Concluiu-se que, embora tenha sido elementar, a prática permitiu desequilíbrios, desafios cognitivos e reflexões críticas aventando potencialidades da Educação Emancipadora em curso de bacharelado.
GENETIC ANALYSIS OF WHEAT ACCESSIONS FOR YIELD CONTRIBUTING TRAITS UNDER WATER DEFICIT CONDITION
Authors: Mustafa Asma , Naeem Atif , Kausar Hina , Ismail Shaguhfta , Mubarak Sidra , Kanwal Bilqees , Naqvi Syed Muhammad Taseer Abbas , Ahmed Zaheer , Maqbool Rizwana
Published: June 2023

Current research was conducted in the field area of Department of Plant Breeding and Genetics, University of Agriculture Faisalabad during 2018-19. Six parents were used as female lines and three parents as male testers. F1 along with their parents were sown under drought and normal conditions in a randomized complete block design. Data were recorded for flag leaf area, chlorophyll contents, plant height, spike length, spikelets per spike, grains per spike, grain weight per spike, relative water contents, spike density, weight of 1000-grain, grain yield from each plant and tillers per plant. F1 plants and their parents were evaluated for general as well as for specific combining ability. The SSR marker-based screening of parental genotypes was also conducted using 4SSR markers related to drought tolerance. Under normal water conditions, parent Chakwal-50 was a good general combiner for plant height and 1000 grain weight, 9774 perform best for spike length and grain weight per spike. Line BARS-2009 performed best for tillers per plant, number of spikes per plant. In drought conditions, for plant height parent AAS11, Chakwal-50 and 10137 gave significant results. Line BARS-2009 and 9774 gave desirable results for number of tillers per plant. Under normal water condition, cross 9774 × Kohistan 97, Chakwal-50 × Sialkot-13, Chakwal-50 × 9733, BARS-2009 × 9496 and Punjab 2011 × Sialkot-13 performed well for chlorophyll content, flag leaf area, 1000-grain weight and tillers/plant. In drought conditions, crosses 9774 × Kohistan 97, AAS-11 × Sialkot-13, 10137 × Sialkot-13 and 10137 × 9496 performed good for plant height, grain weight per spike, flag leaf area and yield per plant. So, it was concluded from physiological and molecular analysis results that among parents Chalwal-50, BARS-2009, 9496 and 10137 were better performing for drought and can be included in future breeding program.