bluuebunny/crossref_metadata_2025 huggingface dataset:
Open-loop polarization mode dispersion mitigation for fibre-optic time and frequency transfer
Authors: Fordell Thomas
Published: February 2022

The non-reciprocal and dynamic nature of polarization mode dispersion (PMD) in optical fibers can be a problem for accurate time and frequency transfer. Here, a simple, passive solution is put forward that is based on transmitting optical pulses with alternating orthogonal polarization. The fast and deterministic polarization modulation means that the PMD noise is pushed far away from the frequencies of interest. Furthermore, upon reflection from a Faraday mirror at the receiver, the pulses have a well-defined polarization when they return to the transmitter, which facilitates stable optical phase detection and fibre phase compensation. In an open-loop test setup that uses a mode-locked laser and a simple pulse interleaver, the polarization mode dispersion is shown to be reduced by more than two orders of magnitude.
Tunable structural colors generated by hybrid Si3N4 and Al metasurfaces
Authors: Wang Lu , Wang Tao , Yan Ruoqin , Yue Xinzhao , Wang Huimin , Wang Yuandong , Zhang Jinyan
Published: February 2022

Metasurfaces with the capability of spectrum manipulation at subwavelength can generate structural colors. However, their practical applications in dynamic displays are limited because their optical performance is immutable after the fabrication of the metasurfaces. In this study, we demonstrate a color-tunable metasurface using numerical analysis. Moreover, we select a low-refractive-index dielectric material, Si3N4, which leaks the electric field to its surroundings. We investigate the potencial of these metasurfaces by simulations to achieve color-tuneable devices with encrypted watermarks. This modulation of colors can be applied to encrypted watermarks, anti-counterfeiting, and dynamic displays.
Low-threshold all-optical nonlinear activation function based on a Ge/Si hybrid structure in a microring resonator
Authors: Wu Bo , Li Hengkang , Tong Weiyu , Dong Jianji , Zhang Xinliang
Published: February 2022

Optical nonlinear activation function is an indispensable part of the optical neural network. While linear matrix computation has thrived in an integrated optical neural network, there are many challenges for nonlinear activation function on a chip such as large latency, high power consumption and high threshold. Here, we demonstrate that Ge/Si hybrid structure would be a qualified candidate owing to its property of CMOS-compatibility, low nonlinear threshold and compact footprint. Thanks to the strong thermal-optic effect of germanium in conjunction with micro-ring resonator, we experimentally demonstrate three different types of nonlinear function (Radial basis, Relu and ELU functions) with a lowest threshold of 0.74 mW among our measured nonlinear functions and they can work well with a repetition rate below 100 kHz. Simultaneous size shrinkage of germanium and resonance constraint inside germanium is proposed to speed up response time. Furthermore, we apply our measured nonlinear activation function to the task of classification of MNIST handwritten digit image dataset and improve the test accuracy from 91.8% to 94.8% with feedforward full-connected neural network containing three hidden layers. It proves that our scheme has potential in the future optical neural network.
ABO blood type and clinical characteristics of patients with ulcerative colitis: A hospital-based study in central Taiwan
Authors: Lai Hsiang-Chun , Chou Jen-Wei , Wu Yi-Hua , Huang Po-Ju , Cheng Ken-Sheng , Chen Tsung-Wei
Published: February 2022

Background

The variations in ABO blood groups are reported to be associated with multiple disorders, including ulcerative colitis (UC). We aimed to investigate the distribution of ABO blood groups in UC patients and explore its impact on disease severity.

Methods

We retrospectively collected 129 UC patients diagnosed at our hospital between January 2000 and November 2019. Clinical characteristics, ABO blood groups, and operation rates were analyzed.

Results

The mean diagnostic age of patients was 38.97 years. Males accounted for the majority of all patients (62.8%). Of 129 patients, 43 (33.3%) were blood type O, 41 (31.8%) were blood type A, 38 (29.5%) were blood type B, and 7 (5.4%) were blood type AB. Although our patients had higher ratio of blood type A comparing our general population, there was no statistically significant association of ABO blood types distribution between these two groups (p = 0.1906). In the subgroup analysis, there were no significant difference of disease locations and operation rates between different ABO blood groups. Furthermore, blood type A patients had higher serum hemoglobin (Hb) levels compared to blood type O patients (13.31 g/dL vs. 12.30 g/dL, p = 0.0347). Blood type A patients had lower serum erythrocyte sedimentation rate (ESR) levels compared to blood type O patients (12.46 mm/hour vs. 21.5 mm/hour, p = 0.0288). Blood type O had higher serum ESR levels compared to non-O groups (p = 0.0228). In the ABO blood groups and mean diagnostic age (≤ 40 years or > 40 years), there were no statistically significant difference between these two age groups, p = 0.5515.

Conclusions

Our results showed ABO blood groups are not associated with UC in spite of a higher ratio of blood type A in our patients. Blood type O patients had higher serum ESR levels; however, blood type A patients had higher Hb levels.
Selected by bioinformatics and molecular docking analysis, Dhea and 2–14,15-Eg are effective against cholangiocarcinoma
Authors: Qin Lei , Kuai Jun , Yang Fang , Yang Lu , Sun Peisheng , Zhang Lanfang , Li Guangpeng
Published: February 2022

Object

To identify novel targets for the diagnosis, treatment and prognosis of cholangiocarcinoma, we screen ideal lead compounds and preclinical drug candidates with MYC inhibitory effect from the ZINC database, and verify the therapeutic effect of Dhea and 2–14,15-Eg on cholangiocarcinoma.

Methods

The gene expression profiles of GSE132305, GSE89749, and GSE45001 were obtained respectively from the Gene Expression Omnibus database. The DEGs were identified by comparing the gene expression profiles of cholangiocarcinoma and normal tissues. GO, KEGG analysis and PPI network analyses were performed. LibDock, ADME and toxicity prediction, molecular docking and molecular dynamics simulations were used to identify potential inhibitors of MYC. Moreover, in vitro, MTT assay, colony-forming assay, the scratch assay and Western blotting were performed to verify the therapeutic effect of Dhea and 2–14,15-Eg.

Results

PPI network analysis showed that ALB, MYC, APOB, IGF1 and KNG1 were hub genes, of which MYC was mainly studied in this study. A battery of computer-aided virtual techniques showed that Dhea and 2–14,15-Eg have lower rodent carcinogenicity, Ames mutagenicity, developmental toxicity potential, and high tolerance to cytochrome P4502D6, as well as could exist stably in natural circumstances. In vitro assays showed that Dhea and 2–14,15-Eg inhibited cholangiocarcinoma cellular viability, proliferation, and migration inhibiting expression of MYC.

Conclusion

This study suggested that Dhea and 2–14,15-Eg were novel potential inhibitors of MYC targeting, as well as are a promising drug in dealing with cholangiocarcinoma and have a perspective application.
The development and pilot testing of a behavioral activation-based treatment for depressed mood and multiple health behavior change in patients with recent acute coronary syndrome
Authors: Gathright Emily C. , Vickery Katherine Diaz , Ayenew Woubeshet , Whited Matthew C. , Adkins-Hempel Melissa , Chrastek Michelle , Carter Jill K. , Rosen Rochelle K. , Wu Wen-Chih , Busch Andrew M.
Published: February 2022

Background

Patients with acute coronary syndrome (ACS) with depressed mood demonstrate poor cardiovascular behavioral risk profiles and elevated risk for recurrent ACS and mortality. Behavioral Activation (BA) offers an intervention framework for an integrated treatment targeting both depression and critical health behaviors post-ACS. Behavioral Activation for Health and Depression (BA-HD) was developed and pilot tested in a multiphase iterative process.

Methods

First, an initial treatment manual was conceptualized based on the team’s prior work, as well as the extant literature. Second, qualitative interviews were conducted with target patients and target providers on the proposed BA-HD treatment rationale, content, and structure. Framework matrix analyses were used to summarize and aggregate responses. Third, an expert panel was convened to elicit additional manual refinements. Finally, patients with post-ACS depression and health behavior non-adherence were recruited to complete an open pilot trial to evaluate acceptability (Client Satisfaction Questionnaire [CSQ], exit interview) and treatment engagement (number of sessions attended; treatment completion was considered completion of 8 out of 10 possible sessions).

Results

The initial BA-HD treatment manual expanded an existing treatment manual for post-ACS BA-based mood management and smoking cessation to target four health behaviors relevant to post-ACS patients (e.g., smoking cessation, medication adherence, physical activity, and diet). After the initial conceptualization, ten post-ACS patients and eight cardiac rehabilitation professionals completed qualitative interviews. Patients endorsed bi-directional interactions between mood and health behaviors post-ACS. Both patients and providers expressed general support of the proposed treatment rationale and values-guided, collaborative goal-setting approach. Patients, providers, and experts provided feedback that shaped the iterative manual development. After the BA-HD manual was finalized, eight participants were enrolled in a single-arm pilot trial. The mean CSQ score was 30.57 ± 2.23, indicating high satisfaction. Seven out of eight (88%) completed treatment. Pre- to post treatment improvements in depressed mood and health behaviors were promising.

Conclusions

BA-HD treatment is an acceptable approach to target both mood and health behaviors in post-ACS patients with depression. A future larger, controlled trial is needed to evaluate the efficacy of the BA-HD treatment.

Trial registration

ClinicalTrials.gov Identifier: NCT04158219
Adapting to change: How has COVID-19 affected people’s work and personal goals?
Authors: Vowels Laura M. , Francois-Walcott Rachel R. R. , Carnelley Katherine B. , Checksfield Emily L.
Published: February 2022

COVID-19 has had a devastating impact on the global economy and affected millions of people’s work and personal lives across the world. The purpose of the present study was to better understand how individuals’ work and personal goals have been affected by the pandemic and how they have adapted to these changes. We conducted qualitative semi-structured interviews (n = 48) and surveyed participants (n = 200) weekly for 5 weeks. Both methods revealed similar themes regarding the adaptation and pursuit of goals (social support, handling unpredictable situations, logistics, solving problems creatively, goal postponement, and no changes). Survey responses also showed that most individuals experienced their goals as more difficult (79%; 13% easier; 9% no change) and found that many had had to adapt or postpone their work and personal goals, often due to logistical difficulties. Businesses and governments should do more to help individuals adapt their goals to the new circumstances.
Bullying victimization among internationally adopted adolescents: Psychosocial adjustment and moderating factors
Authors: Ferrari Laura , Caravita Simona , Ranieri Sonia , Canzi Elena , Rosnati Rosa
Published: February 2022

Bullying constitutes a serious risk factor for the psychosocial adjustment of young people in both the general population and minority groups. Among minorities, international adoptees are likely to show a specific vulnerability to the experience of being bullied, moderated by specific risk and protective factors. This study aimed to investigate the association between adoptees’ experience of bullying victimization and their psychosocial adjustment, and to explore the moderating role of adoptive identity and reflected minority categorization. An online, anonymous self-report questionnaire was completed by 140 adolescents (13–17 years), who were internationally adopted by Italian families. Findings showed that being victimized was associated with higher levels of emotional and behavioral difficulties, but that the strength of this relation varied according to the levels of adoptive identity and reflected minority categorization. Specifically, victimization was found to have a more detrimental and negative impact on psychological adjustment for adoptees who were highly identified with the adoptive group, and reported to be less perceived by others as members of the minority group. Results are discussed in relation to recommendations for further research as well as for professionals working with internationally adopted adolescents.
Narratives and counter-narratives in religious responses to COVID-19: A computational text analysis
Authors: Idler Ellen , Bernau John A. , Zaras Dimitrios
Published: February 2022

Religious responses to COVID-19 as portrayed in a major news source raise the issue of conflict or cooperation between religious bodies and public health authorities. We compared articles in the New York Times relating to religion and COVID-19 with the COVID-19 statements posted on 63 faith-based organizations’ web sites, and with the guidance documents published by the Centers for Disease Control and Prevention (CDC) and World Health Organization (WHO) specifically for religious bodies. We used computational text analysis to identify and compare sentiments and topics in the three bodies of text. Sentiment analysis showed consistent positive values for faith-based organizations’ texts throughout the period. The initial negative sentiment of religion—COVID-19 coverage in the New York Times rose over the period and eventually converged with the consistently positive sentiment of faith-based documents. In our topic modelling analysis, rank order and regression analysis showed that topic prevalence was similar in the faith-based and public health sources, and both showed statistically significant differences from the New York Times. We conclude that there is evidence of both narratives and counter-narratives, and that these showed demonstrable shifts over time. Text analysis of public documents shows alignment of the interests of public health and religious bodies, which can be discerned for the benefit of communities if parties are trusted and religious messages are consistent with public health communications.
Preventive practices toward sexually transmitted infections and their determinants among young people in Ethiopia: A protocol for systematic review and meta-analysis
Authors: Anbesu Etsay Woldu , Aychiluhm Setognal Birara , Alemayehu Mussie
Published: February 2022

Background

Globally, the estimated annual number of new cases of curable sexually transmitted infections occurring among young people aged 15–24 years is approximately 178.5 million. There are fragmented and inconsistent findings on preventive practices for sexually transmitted infections. Thus, this systematic review and meta-analysis protocol aimed to estimate the pooled prevalence of preventive practices of sexually transmitted infections and identify its determinants among young people in Ethiopia.

Methods

The Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) will be used to develop the review protocol. Online databases such as PubMed, CINAHL, Scopus, Google, and Google Scholar will be used to search published and unpublished studies. The Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument will be used to assess the quality of the study. Statistical heterogeneity will be checked using the Cochran Q test and I2 statistics. Subgroup analysis and meta-regression will be performed to identify the sources of heterogeneity. The statistical analysis will be performed using STATA version 14 software. A random-effects model will be performed to estimate the pooled prevalence and identify determinants of preventive practices of sexually transmitted infections.

Discussion

Young people have a high unmet need for sexual and reproductive health services and poor preventive practices toward sexually transmitted infections. Although there are studies on preventive practices for sexually transmitted infections, there is no study finding on the pooled prevalence of preventive practices for sexually transmitted infections and its determinants among young people in Ethiopia. Thus, this systematic review and meta-analysis protocol will help to develop appropriate strategies.
Psychosis risk among pregnant women in Ghana
Authors: Adjorlolo Samuel , Mensah Gwendolyn , Badzi Caroline Dinam
Published: February 2022

Introduction

Psychotic illness, although is rare, has been reported in the perinatal period. Individuals diagnosed with psychotic illness tend to first exhibit psychotic-like experiences (PLEs), defined as subclinical psychotic symptoms that occur outside the context of sleep or drug use. However, there is a paucity of empirical data on PLEs in pregnancy to advance scholarly discourse and support professional practice. The current study investigated the prevalence and correlates of PLEs among pregnant women in Ghana, a West African state.

Design

A cross-sectional survey design was used to collect data from 702 pregnant women who responded to measures of PLEs, COVID-19 concerns and behavioral maladies such as anxiety and depressive symptoms. Descriptive and inferential statistics, namely chi square, exploratory factor analysis, MANOVA and multinomial logistic regression were used to analyze the data.

Results

The results showed that 54.2%, 27.3% and 18.5% of participants were at no/low, moderate and high risk for psychosis, respectively. A total of 44.4% participants were not distressed by PLEs, whereas 32.2% and 23.4% were a bit/quite and very distressed, respectively. Psychosis risk was elevated among pregnant women who were more concerned about the COVID-19 effects, scored high in suicidal ideation, depressive symptoms and sleep difficulties.

Conclusion

The study showed that psychosis risk is present in pregnancy.

Implications

Screening for psychosis risk in pregnancy should be prioritized for pregnant women with behavioral maladies, including suicidal tendencies, depressive symptoms, sleep difficulties and heightened concerns about COVID-19.
Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness
Authors: Dror Amiel A. , Morozov Nicole , Daoud Amani , Namir Yoav , Yakir Orly , Shachar Yair , Lifshitz Mark , Segal Ella , Fisher Lior , Mizrachi Matti , Eisenbach Netanel , Rayan Doaa , Gruber Maayan , Bashkin Amir , Kaykov Edward , Barhoum Masad , Edelstein Michael , Sela Eyal
Published: February 2022

Objective

Studies have demonstrated a potential correlation between low vitamin D status and both an increased risk of infection with SARS-CoV-2 and poorer clinical outcomes. This retrospective study examines if, and to what degree, a relationship exists between pre-infection serum 25-hydroxyvitamin D (25(OH)D) level and disease severity and mortality due to SARS-CoV-2.

Participants

The records of individuals admitted between April 7th, 2020 and February 4th, 2021 to the Galilee Medical Center (GMC) in Nahariya, Israel, with positive polymerase chain reaction (PCR) tests for SARS-CoV-2 (COVID-19) were searched for historical 25(OH)D levels measured 14 to 730 days prior to the positive PCR test.

Design

Patients admitted to GMC with COVID-19 were categorized according to disease severity and level of 25(OH)D. An association between pre-infection 25(OH)D levels, divided between four categories (deficient, insufficient, adequate, and high-normal), and COVID-19 severity was ascertained utilizing a multivariable regression analysis. To isolate the possible influence of the sinusoidal pattern of seasonal 25(OH)D changes throughout the year, a cosinor model was used.

Results

Of 1176 patients admitted, 253 had records of a 25(OH)D level prior to COVID-19 infection. A lower vitamin D status was more common in patients with the severe or critical disease (<20 ng/mL [87.4%]) than in individuals with mild or moderate disease (<20 ng/mL [34.3%] p < 0.001). Patients with vitamin D deficiency (<20 ng/mL) were 14 times more likely to have severe or critical disease than patients with 25(OH)D ≥40 ng/mL (odds ratio [OR], 14; 95% confidence interval [CI], 4 to 51; p < 0.001).

Conclusions

Among hospitalized COVID-19 patients, pre-infection deficiency of vitamin D was associated with increased disease severity and mortality.
Linguistic metaconcepts can improve grammatical understanding in L1 education evidence from a Dutch quasi-experimental study
Authors: van Rijt Jimmy , Myhill Debra , De Maeyer Sven , Coppen Peter-Arno
Published: February 2022

This mixed-method quasi-experimental study examined whether metaconceptual grammar teaching impacts on (a) students’ L1 grammatical understanding, (b) their ‘blind’ use of grammatical concepts and (c) their preference of using explicit grammatical concepts over everyday concepts in explaining grammatical problems. Previous research, involving single group pre-postintervention designs, found positive effects for metaconceptual interventions on secondary school students’ grammatical reasoning ability, although a negative side effect seemed to be that some students started using grammatical concepts ‘blindly’ (i.e., in an inaccurate way). While there are thus important clues that metaconceptual grammar teaching may lead to increased grammatical understanding, there is a great need for more robust empirical research. The current study, involving 196 Dutch 14-year old pre-university students, is a methodological improvement of previous work, adopting a switching replications design. Bayesian multivariate analyses indicate medium to large effects from the metaconceptual intervention on students’ grammatical understanding. The study found a similar effect of the intervention on students’ ability to use explicit grammatical concepts over everyday concepts in tackling grammatical problems. No evidence for increased ‘blind’ concept use as a negative byproduct of the intervention was found. Additional qualitative analyses of in-intervention tasks provided further evidence for the effectiveness of metaconceptual interventions, and seemed to indicate that cases of blind concept use, rather than being a negative side effect, might actually be part of a gradual process of students’ growing understanding of grammatical (meta)concepts. We discuss these findings in relation to previous work and conclude that linguistic metaconcepts can improve L1 grammatical understanding.
Founder transformants of cotton (Gossypium hirsutum L.) obtained through the introduction of DS-Red, Rec, Rep and CRISPR/Cas9 expressing constructs for developing base lines of recombinase mediated gene stacking
Authors: Aslam Sabin , Khan Sultan Habibullah , Ahmad Aftab , Walawage Sriema Lalani , Dandekar Abhaya M.
Published: February 2022

Cotton being the major fiber crop across the world is exposed to numerous biotic and abiotic stresses. Genetic transformation of cotton is vital to meet the world’s food, feed and fiber demands. Genetic manipulation by randomly transferring the genes emanate variable gene expression. Targeted gene insertion by latest genome editing tools results in predictable expression of genes at a specified location. Gene stacking technology emerged as an adaptive strategy to combat biotic and abiotic stresses by integrating 2–3 genes simultaneously and at a specific site to avoid variable gene expression at diverse locations. This study explains the development of cotton’s founder transformants to be used as a base line for multiple gene stacking projects. We introduced Cre and PhiC31 mediated recombination sites to specify the locus of incoming genes. CRISPR-Cas9 gene was integrated for developing CRISPR based founder lines of cotton. Cas9 gene along with gRNA was integrated to target Rep (replication) region of cotton leaf curl virus. Replication region of virus was specifically targeted to diminish further proliferation and preventing the virus to develop new strains. To successfully develop these primary transformants, a model transformation system has been optimized with the red color visualization (DS-Red). Following red color transformation system, three baselines with recombination specified site (Rec), targeted replication region (Rep) and Cas9 founder lines have been developed. These founder transformants are useful for developing recombinase mediated and CRISPR/Cas9 based originator lines of cotton. Moreover, these transformants will set up a base system for all the recombinase mediated gene stacking projects.
Analysis of breast cancer survival in a northeastern Brazilian state based on prognostic factors: A retrospective cohort study
Authors: Marques Adriane Dórea , Moura Alex Rodrigues , Hora Evânia Curvelo , Brito Érika de Abreu Costa , Oliviera Leonardo Souto , Feitosa Ionara Rodrigues , Freitas Flavia Fernandes , Lima Marcela Sampaio , de Carvalho Barreto Íkaro Daniel , Santos Marceli Oliveira , da Silva Angela Maria , Lima Carlos Anselmo
Published: February 2022

Breast cancer is a major health problem worldwide. Analysis of breast cancer epidemiology in emerging countries enables assessment of prognostic factors, cancer care quality, and the equity of resource distribution. We aimed to estimate the overall (OS) and cancer-specific survival (SS) of breast cancer patients in the northeastern Brazilian state of Sergipe to identify independent prognostic factors. We analyzed a cohort for the factors age at diagnosis, place of residence, time to treatment, staging, and molecular classification, using the Kaplan–Meier method, log-rank test, Pearson’s chi-squared test and Cox regression model. The outcome was the vital status at the end of the study. Our analysis showed an OS probability of 0.72 and an SS probability of 0.75. In multivariate analysis, time to treatment within 60 days, stage IV, and triple-negative classification remained independent prognostic factors for both OS [unadjusted hazard ratio (HRp) 1.50 (1.21; 1.86), HRp 16.56 (8.35; 32.85), and HRp 2.73 (1.73; 4.29), respectively] and SS [HRp 1.43 (1.13; 1.81), HRp 20.53 (9.45; 44.56), and HRp 3.14 (1.88; 5.26), respectively]. Better survival was demonstrated for the following patients: those receiving their first treatment after 60 days, with an OS of 52.5 months (51.2; 53.8) and SS of 53.5 months (52.3; 54.7); stage I patients, with an OS of 58.8 months (57.7; 60.0) and SS of 59.2 months (58.1; 60.3); patients without nodal metastasis, with an OS of 54.2 months (53.0; 55.4) and SS of 55.6 months (54.5; 56.7); and patients with luminal A classification, with an OS of 56.8 months (55.0; 58.5) and SS of 57.8 months (56.2; 59.4). This study identified independent prognostic factors and that OS and SS were lower for patients from Sergipe than for patients in high-income areas. Therefore, determining the profiles of breast cancer patients in this population will inform specific cancer care.
Exploration of clinicians’ decision-making regarding transfer of patient care from the emergency department to a medical assessment unit: A qualitative study
Authors: Cleak Helen , Osborne Sonya R. , de Looze Julian W. M.
Published: February 2022

Background

Hospitals face immense pressures in balancing patient throughput. Medical assessment units have emerged as a commonplace response to improve the flow of medical patients presenting to the emergency department requiring hospital admission and to ease overcrowding in the emergency department. The aim of this study was to understand factors influencing the decision-making behaviour of key stakeholders involved in the transfer of care of medical patients from one service to the other in a large, tertiary teaching hospital in Queensland, Australia.

Methods

We used a qualitative approach drawing on data from focus groups with key informant health and professional staff involved in the transfer of care. A theoretically-informed, semi-structured focus group guide was used to facilitate discussion and explore factors impacting on decisions made to transfer care of patients from the emergency department to the medical assessment unit. Thematic analysis was undertaken to look for patterns in the data.

Results

Two focus groups were conducted with a total of 15 participants. Four main themes were identified: (1) we have a process—we just don’t use it; (2) I can do it, but can they; (3) if only we could skype them; and (4) why can’t they just go up. Patient flow relies on efficiency in two processes—the transfer of care and the physical re-location of the patient from one service to the other. The findings suggest that factors other than clinical reasoning are at play in influencing decision-making behaviour.

Conclusions

Acknowledgement of the interaction within and between professional and health staff (human factors) with the organisational imperatives, policies, and process (system factors) may be critical to improve efficiencies in the service and minimise the introduction of workarounds that might compromise patient safety.
Quantitative determination of pulmonary emphysema in follow-up LD-CTs of patients with COVID-19 infection
Authors: Celik Erkan , Nelles Christian , Kottlors Jonathan , Fervers Philipp , Goertz Lukas , Pinto dos Santos Daniel , Achenbach Tobias , Maintz David , Persigehl Thorsten
Published: February 2022

Purpose

To evaluate the association between the coronavirus disease 2019 (COVID-19) and post-inflammatory emphysematous lung alterations on follow-up low-dose CT scans.

Methods

Consecutive patients with proven COVID-19 infection and a follow-up CT were retrospectively reviewed. The severity of pulmonary involvement was classified as mild, moderate and severe. Total lung volume, emphysema volume and the ratio of emphysema/-to-lung volume were quantified semi-automatically and compared inter-individually between initial and follow-up CT and to a control group of healthy, age- and sex-matched patients. Lung density was further assessed by drawing circular regions of interest (ROIs) into non-affected regions of the upper lobes.

Results

A total of 32 individuals (mean age: 64 ± 13 years, 12 females) with at least one follow-up CT (mean: 52 ± 66 days, range: 5–259) were included. In the overall cohort, total lung volume, emphysema volume and the ratio of lung-to-emphysema volume did not differ significantly between the initial and follow-up scans. In the subgroup of COVID-19 patients with > 30 days of follow-up, the emphysema volume was significantly larger as compared to the subgroup with a follow-up < 30 days (p = 0.045). Manually measured single ROIs generally yielded lower attenuation values prior to COVID-19 pneumonia, but the difference was not significant between groups (all p > 0.05).

Conclusion

COVID-19 patients with a follow-up CT >30 days showed significant emphysematous lung alterations. These findings may help to explain the long-term effect of COVID-19 on pulmonary function and warrant validation by further studies.
Occurrence and spatial distribution of heavy metals in landfill leachates and impacted freshwater ecosystem: An environmental and human health threat
Authors: Essien Joseph P. , Ikpe Donald I. , Inam Edu D. , Okon Aniefiokmkpong O. , Ebong Godwin A. , Benson Nsikak U.
Published: February 2022

Municipal landfill leachates are a source of toxic heavy metals that have been shown to have a detrimental effect on human health and the environment. This study aimed to assess heavy metal contamination in leachates, surface water, and sediments from non-sanitary landfills in Uyo, Nigeria, and to identify potential health and environmental effects of leachate contamination. Over the wet and dry seasons, surface water and sediment samples were collected from an impacted freshwater ecosystem, and leachates samples from six monitoring wells. Elemental analyses of samples were conducted following standard analytical procedures and methods. The results indicated that leachate, surface water, and sediment samples all had elevated levels of heavy metals, implying a significant impact from landfills. Pollution indices such as the potential ecological risk index (PERI), pollution load index (PLI), degree of contamination (Cd), modified degree of contamination (mCd), enrichment factor (EF), geoaccumulation index (Igeo), and Nemerov pollution index (NPI) were used to assess the ecological impacts of landfill leachates. The following values were derived: PERI (29.09), PLI (1.96E-07), Cd (0.13), mCd (0.16), EF (0.97–1.79E-03), Igeo (0), and NPI (0.74). Pollution indicators suggested that the sediment samples were low to moderately polluted by chemical contaminants from the non-sanitary landfills, and may pose negative risks due to bioaccumulation. Human health risks were also assessed using standard risk models. For adults, children, and kids, the incremental lifetime cancer rate (ILCR) values were within the acceptable range of 1.00E-06–1.00E-04. The lifetime carcinogenicity risks associated with oral ingestion exposure to heavy metals were 9.09E-05, 1.21E-05, and 3.60 E-05 for kids, adults, and children, respectively. The mean cumulative risk values for dermal exposures were 3.24E-07, 1.89E-06, and 1.17E-05 for adults, children, and kids, respectively. These findings emphasized the risks of human and biota exposure to contaminants from landfills.
A systematic review on risk factors for khat chewing among adolescents in the African continent and Arabian Peninsula
Authors: Fiidow Osman Abubakar , Minhat Halimatus Sakdiah , Zulkefli Nor Afiah Mohd , Ahmad Norliza
Published: February 2022

Introduction

Khat is a flowering plant with stimulant effect on the nervous system and produce psychological dependence. Despite its harmful effects, the ingestion of khat has been part of cultural norms and the legality of khat varies by region.

Objective

This systematic review aimed at critically evaluating the available evidence on the risk factors of khat chewing among adolescents.

Methods

A systematic review was conducted on published research studies from five databases Scopus, PubMed, Science-direct, Ovid and google scholar using keywords khat chewing OR qat chewing AND associated factors OR risk factors OR contributing factors AND adolescents OR teenagers. Articles included were either cross-sectional, cohort, case-control or qualitative studies which were published between the year 1990 till present. Excluded articles were the non-English written articles, descriptive studies and irrelevant topics being studied.

Results

Out of 2617 records identified and screened, six were included for the analysis and interpretation of the data. All included studies were cross-sectional study design. All six studies reported having family members who chewed khat significantly predict khat chewing among adolescents, followed by five articles for friends or peers who also chewed khat and four articles for male gender. Smoking was also found to have the highest odds (OR = 18.2; 95% CI: 12.95–25.72) for khat chewing among adolescents.

Conclusion

The review highlights the crucial role of family members, friends or peers and male gender to predict khat chewing among adolescents. Effectiveness of health promotion programs to educate and reduce khat chewing among adolescents will require active participation of family members and friends.
Effect of collagen casing on the quality characteristics of fermented sausage
Authors: Yan Xinlei , Yang Le , Zhang Yanni , Han Wenying , Duan Yan
Published: February 2022

Objective

Fermented sausage is popular all over the world for its rich nutrition and unique flavor. Sausage casing is one of the key factors affecting the quality of fermented sausage. However, there is little information involved in this field.

Methods

In this study, collagen casings were used as a wrapping material, and natural casings (pig casings) were used as a control. The effects of the two types of casings on biogenic amine content and other quality characteristics of fermented sausage were analyzed with increasing the storage time.

Results

The results showed that with storage time increasing, the hardness and gumminess of fermented sausage in collagen casing (CC) group were higher than those in pig casing (PC) group (P<0.05), while the elasticity in CC group was lower than that in PC group (P<0.05). In the processing and storage period, there was no significant difference in the type and content of flavor substances between the two groups. More importantly, the contents of tryptamine, putrescine, cadaverine, histamine, tyramine and phenyethylamine in fermented sausage of CC group were lower than those in PC group (P<0.05).

Conclusion

In conclusion, this study revealed that CC could improve the quality characteristics of fermented sausage and reduce the content of biogenic amines in fermented sausage, which provides a theoretical basis for the choice of casings in industrial production in the future.
Guideline adherence in speech and language therapy in stroke aftercare. A health insurance claims data analysis
Authors: Schindel Daniel , Mandl Lena , Schilling Ralph , Meisel Andreas , Schenk Liane
Published: February 2022

Background

Impairments to comprehension and production of speech (aphasia, dysarthria) and swallowing disorders (dysphagia) are common sequelae of stroke, reducing patients’ quality of life and social participation. Treatment oriented on evidence-based guidelines seems likely to improve outcomes. Currently, little is known about guideline adherence in stroke aftercare for the above-mentioned sequelae. This study aims to analyse guideline adherence in the treatment of aphasia, dysarthria and dysphagia after stroke, based on suitable test parameters, and to determine factors that influence the implementation of recommended therapies.

Methods

Six test parameters were defined, based on systematic study of guidelines for the treatment of speech impairments and swallowing disorders (e.g. comprehensive diagnostics, early initiation and continuity). Guideline adherence in treatment was tested using claims data from four statutory health insurance companies. Multivariate logistic and linear regression analyses were performed in order to test the outcomes.

Results

4,486 stroke patients who were diagnosed with specific disorders or received speech therapy were included in the study. The median age was 78 years; the proportion of women was 55.9%. Within the first year after the stroke, 90.3% of patients were diagnosed with speech impairments and swallowing disorders. Overall, 44.1% of patients received outpatient speech and language therapy aftercare. Women were less frequently diagnosed with specific disorders (OR 0.70 [95%CI:0.55/0.88], p = 0.003) and less frequently received longer therapy sessions (OR 0.64 [95%CI:0.43/0.94], p = 0.022). Older age and longer hospitalization duration increased the likelihood of guideline recommendations being implemented and of earlier initiation of stroke aftercare measures.

Conclusions

Our observations indicate deficits in the implementation of guideline recommendations in stroke aftercare. At the same time, they underscore the need for regular monitoring of implementation measures in stroke aftercare to address group-based disparities in care.
Clinical practice guidelines and consensus statements for antenatal oral healthcare: An assessment of their methodological quality and content of recommendations
Authors: Wilson Annika , Hoang Ha , Bridgman Heather , Crocombe Leonard , Bettiol Silvana
Published: February 2022

Objectives

To review the content of recommendations within antenatal oral healthcare guidance documents and appraise the quality of their methodology to inform areas of development, clinical practice, and research focus.

Method

A systematic search of five electronic databases, Google search engine, and databases from relevant professional and guideline development groups published in English, developed countries, and between 2010 and 2020 was undertaken to identify guidance documents related to antenatal oral healthcare. Quality of documents was appraised using the Appraisal of Guidelines Research and Evaluation II tool, and a 3-step quality cut-off value was used. Inductive thematic analysis was employed to categories discreet recommendations into themes.

Results

Six guidelines and one consensus statement were analysed. Two documents developed within Australia scored ≥60% across five of the six domains of the quality appraisal tool and were recommended for use. Four documents (developed in the United States and Canada) were recommended for use with modifications, whilst one document (developed in Europe) was not recommended. A total of 98 discreet recommendations were identified and demonstrated considerable unanimity but differed in scope and level of information. The main content and number of recommendations were inductively categorised within the following clinical practice points: risk factor assessments (n = 2), screening and assessment (n = 10), pre-pregnancy care (referral, n = 1), antenatal care (health education and advice, n = 14; management of nausea and vomiting, n = 7; referral, n = 2), postnatal care (health education and advice, n = 1; anticipatory guidance, n = 6), documentation (n = 4), coordinated care (n = 4), capacity building (n = 6), and community engagement (n = 1).

Conclusion

The methodological rigour of included guidance documents revealed areas of strengths and limitations and posit areas for improvement. Further research could centre on adapting antenatal oral healthcare guidelines and consensus statements to local contexts. More high-quality studies examining interventions within antenatal oral healthcare are needed to support the development of recommendations.
Impact of face masks and sunglasses on emotion recognition in South Koreans
Authors: Kim Garam , Seong So Hyun , Hong Seok-Sung , Choi Eunsoo
Published: February 2022

Due to the prolonged COVID-19 pandemic, wearing masks has become essential for social interaction, disturbing emotion recognition in daily life. In the present study, a total of 39 Korean participants (female = 20, mean age = 24.2 years) inferred seven emotions (happiness, surprise, fear, sadness, disgust, anger, surprise, and neutral) from uncovered, mask-covered, sunglasses-covered faces. The recognition rates were the lowest under mask conditions, followed by the sunglasses and uncovered conditions. In identifying emotions, different emotion types were associated with different areas of the face. Specifically, the mouth was the most critical area for happiness, surprise, sadness, disgust, and anger recognition, but fear was most recognized from the eyes. By simultaneously comparing faces with different parts covered, we were able to more accurately examine the impact of different facial areas on emotion recognition. We discuss the potential cultural differences and the ways in which individuals can cope with communication in which facial expressions are paramount.
Romkocsma mint bricolage: Élményközpontú szolgáltatásérték-teremtés a romkocsmákban
Authors: Mitev Ariel , Kelemen-Erdős Anikó
Published: February 2022

A romkocsma-jelenség jól leírható a bricolage fogalmával, melynek középpontjában a fogyasztói élmények megteremtése (fabrikálása) áll. A szolgáltatás folyamatainak kulcsa ugyanis a service-dominant logic (szolgál­tatás-központú elmélet), melynek keretében a közös értékteremtést, az elkötelezettséget, valamint az élmények rendszerét elemezzük. Célunk annak vizsgálata, hogy a fogyasztói és vállalati kölcsönös értékteremtés és az elkötelezettség, miként értelmezhető és hogyan van jelen a romkocsmáknál, valamint ezek miként hatnak az élmény-értékre és a vásárlási szándékra. Varianciaalapú SEM modellezés segítségével bemutatjuk az értékte­remtési folyamat meghatározó észlelt elemeit, valamint a köztük lévő összefüggéseket.
Látogatómenedzsment a hazai védett természeti területeken
Authors: Benkhard Borbála , Martonné Erdős Katalin
Published: February 2022

A védett természeti területeken folyó turizmus tervezésekor, szervezésekor az értékek védelme érdekében kiemelt figyelmet kell fordítani a látogatómenedzsment-technikák tudatos és széles körű alkalmazására. Míg külföldön ennek a kérdéskörnek a kutatottsága, szakirodalma és gyakorlati alkalmazása egyaránt jelentős, addig hazánkban az egyes eszközök előnyei kevésbé ismertek, illetve korántsem aknázzuk ki a ben­nük rejlő lehetőségeket. Az egyes védett területeken bevezetett intézkedések, technikák között tapasztalha­tó különbségek többnyire az eltérő területi adottságokra vezethetőek vissza. Ugyanakkor megfigyelhető, hogy a nemzetipark-igazgatóságok ökoturisztikai szakemberei eltérően vélekednek azok hatékonyságáról és elfogadottságáról, aminek oka a látogatók körének különbözősége mellett az alkalmazható, illetve alkalmazott módszerek előnyeinek alacsony kihasználtsága.
(Re)ver, (re)lembrar e bordar
Authors: Mariano Julia , Rodrigues Borges Deborah
Published: February 2022

Esta escrita sustenta-se em memórias de experiências vividas por duas educadoras-fotógrafas em oficinas de fotografias com idosos alunos da Universidade Aberta à Terceira Idade (UNATI- PUC Goiás).  A partir das memórias das vivências em um projeto de bordar lembranças sobre fotografias de álbuns de família, são trazidas aprendizagens que emergiram em contatos e trocas de saberes dessa experiência intergeracional e interinstitucional, possibilitando o reviver de memórias e a emergência de novas narrativas sobre elas.
Narrativas de um mundo em ruínas:
Authors: Amaral Sales Tiago , Alves Maria Carolina , Gomes Lourenço Keyme , Paixão Lelis da Silva Roberta , Machado Borges Nicole Cristina , Dinelli Estevinho Lúcia de Fátima , Franco Carvalho Daniela
Published: February 2022

Em meio à pandemia de covid-19, olhamos para os lados e percebemos um mundo em ruínas, desmoronando incessantemente. A partir dos encontros proporcionados pela disciplina Conexões entre Ciências, Artes e Culturas do Programa de Pós-graduação em Educação da Universidade Federal de Uberlândia, produzimos narrativas que foram entretecidas neste texto. Entre o caos e esgotamento de possíveis, colocamo-nos em movimentos de criar nas conexões entre ciência, arte e educação. Dando vazão aos afetos que pediam passagens em nossos corpos, dialogamos com autores como Ailton Krenak, Anna Tsing, Gilles Deleuze, Félix Guattari, Donna Haraway e Pereira e colaboradores para pensar no Antropoceno, buscar saídas e, quando não as encontramos, criar fugas e outros caminhos.
Family Financial Socialization and Wealth Decisions
Authors: Bucciol Alessandro , Manfrè Martina , Veronesi Marcella
Published: February 2022

We study the relationship between family financial socialization acquired during adolescence and a wide range of wealth decisions during adulthood, and compare the correlation of family financial socialization with that of financial literacy. Our findings highlight the importance of family financial socialization during young age on all the dimensions investigated, except for risky asset holding. The correlations between family financial socialization and wealth decisions are not different from those of financial literacy except for the size of financial assets, risky assets holding, and debt holding. While for males both financial literacy and financial socialization are correlated with wealth decisions, for females mainly family financial socialization seems to matter. Our findings underline the importance of acquiring financial education not only through proper educational programs, but also in the family environment during adolescence, where teens can learn positive attitudes towards money that are maintained throughout their life.