bluuebunny/crossref_metadata_2025 huggingface dataset:
Phase I study of repeated peripheral infusions of anti-EGFRvIII CAR T cells in combination with pembrolizumab in patients with newly diagnosed, MGMT-unmethylated glioblastoma
Authors: Bagley Stephen J. , Binder Zev A. , Desai Arati S. , Nasrallah Maclean P. , Maloney Eileen , Brem Steven , Lustig Robert , Kurtz Goldie , Alonso-Basanta Michelle , Mohan Suyash , Hwang Wei-Ting , Tang Oliver Y. , Logun Meghan , Bhattacharyya Meghna , Markowitz Kelly , Delman Devora , Marshall Amy , Alanio Cecile , Beatty Gregory L. , Brogdon Jennifer L. , Hexner Elizabeth , O'Rourke Donald M.
Published: March 2023

Treatment efficacy with chimeric antigen receptor (CAR) T cell therapy in glioblastoma (GBM) is undermined by an immunosuppressive tumor microenvironment (TME). We previously showed that CAR T cell therapy targeting epidermal growth factor receptor variant III (EGFRvIII) produces anti-tumor activity against recurrent GBM and causes upregulation of programmed death-ligand 1 (PD-L1) in the TME. Here, we conducted a phase I trial to study the impact of CART-EGFRvIII cells administered concomitantly with the PD-1 inhibitor pembrolizumab in patients (n = 7) with newly diagnosed, EGFRvIII + GBM. Treatment was well tolerated without incidence of dose-limiting toxicity. However, no signal of efficacy was detected with a median progression-free survival of 5.2 months (90% CI, 2.9–6.0 months) and median overall survival of 11.8 months (90% CI, 9.2–14.2 months). In addition, PD-1 expression in the CART-EGFRvIII infusion product did not correlate with outcomes, and peripheral CAR T cell engraftment was relatively short-lived. Together, these findings show the safety of combining CAR T cells and PD-1 inhibition in GBM but given the lack of efficacy, also indicate a need to consider alternative combinatorial strategies. ClinicalTrials.gov registration: NCT03726515.
Relativistic Particle Measurements in Jupiter’s Magnetosphere with Pix.PAN
Authors: Hulsman Johannes , Wu Xin , Azzarello Philipp , Bergmann Benedikt , Campbell Michael , Clark George , Cadoux Franck , Ilzawa Tomoya , Kollmann Peter , Llopart Xavier , Nénon Quentin , Paniccia Mercedes , Roussos Elias , Smolyanskiy Petr , Sukhonos Daniil , Thonet Pierre Alexandre
Published: March 2023

Pix.PAN is a compact cylindrical magnetic spectrometer, intended to provide excellent high energy particle measurements under high rate and hostile operating conditions in space. Its principal design is composed of 2 Halbach-array magnetic sectors and 6 Timepix4-based tracking layers; the latest hybrid silicon pixel detector readout ASIC designed. Due to Pix.PAN's compact and relatively simple design, it has the potential to be used for space missions exploring with measurements of unprecedented precision, high energy particles in radiation belts and the heliophere (solar energetic particles, anomalous and galactic cosmic rays). In this white paper, we discuss the design and expected performance of Pix.PAN for COMPASS (Comprehensive Observations of Magnetospheric Particle Acceleration, Sources, and Sinks), a mission concept submitted to NASA’s Call "B.16 Heliophysics Mission Concept Studies (HMCS)" in 2021 that targets the extreme high energy particle environment of Jupiter's inner radiation belts. We also discuss PixPAN's operational conditions and interface requirements. The conceptual design shows that is possible to achieve an energy resolution of <12% for electrons in the range of 10MeV-1GeV and <35% for protons between ~200MeV to a few GeV. Due to the timestamp precision of Timepix4, a time resolution (on an instrument level) of about 100ps can be achieved for time-of-flight measurements. In the most intense radiation environments of the COMPASS mission, Pix.PAN is expected to have a maximum hit rate of 44MHz/cm2 which is below the design limit of 360MHz/cm2 of Timepix4. Finally, a sensor design is proposed which allows the instrument to operate with a power budget of 20W without the loss of scientific performance.
Io: A Unique World in our Solar System
Authors: Pommier Anne , McEwen Alfred
Published: March 2023

Jupiter’s moon Io is the most volcanically active world in our Solar System. Eruptions on Io sustain its atmosphere, feed the Jovian magnetosphere, and contaminate neighboring moons. This unique volcanic and tectonic activity is powered by tidal heating, caused by its gravitational interactions with Jupiter and other moons. The silicate crust of Io is coated with sulfur compounds, and its interior—one that is exceptional for an outer-planet moon—is composed of a metallic core and a silicate mantle that may host a magma ocean. Such spectacular large-scale volcanism and high heat flow provide insights into the processes that shaped all terrestrial bodies. Future exploration of Io would answer key questions and herald a new era of discoveries about the evolution of terrestrial planets and moons within our Solar System and beyond.
Io’s Volcanic Activity and Atmosphere
Authors: Davies Ashley Gerard , Vorburger Audrey Helena
Published: March 2023

Driven by tidal heating, Io’s extreme volcanism has created a young, impact crater–free surface dominated by hundreds of active volcanic centres. From these volcanoes erupt voluminous, low-viscosity, high-temperature silicate lavas. Volcanic plumes, from venting gas and mobilised surface ices (primarily SO2 and S), contribute to Io’s thin atmosphere. Away from volcanoes, SO2 ice on the surface alternately sublimes during the daytime and condenses during eclipses and at night, resulting in a strong day/night atmospheric dichotomy. Sunlight and radiation bombardment at high altitude breaks the gas molecules apart, leading to the formation of SO, O, O2, S, K, Na, and Cl. These atoms reside as both neutral and charged particles in clouds that are found along Io’s orbit around Jupiter.
Institutional Problems of Spatial Development Strategization
Authors: Bukhvald E. M.
Published: March 2023

The Spatial Development Strategy of the Russian Federation adopted in 2019 for the period up to 2025 not only remains in the “field of view” of economic theorists and practitioners of public administration, but also in many ways continues to embody the complexity and inconsistency of the strategic planning system in the country. Of course, we have to admit that many of the initial assumptions of the development of this Strategy did not work out quite well. Thus, to date, it has not been possible to adopt the Concept of State Regional Policy, which has been repeatedly proposed in different versions, and on this basis to carry out a meaningful and targeted differentiation of the concepts of “regional” and “spatial” development. Contrary to the logic of the preparation of strategic planning documents, fixed already in the initial version of Federal law No.172, Spatial development strategy was developed and approved in the absence of a “basic” document defining the strategic objectives of the socio-economic development of the country for the future. The actual lack of a deep scientific and public expertise of this Strategy also played a negative role. Formally, there were a lot of different discussions; one draft document was replaced by another over and over again, but the comments and suggestions received were left without due attention, and these discussions did not give a positive result. As a result, it turned out that some variants of the Strategy were discussed, and a completely different one was adopted. As a result, there were more gaps in this Strategy than significant advances. Most of these gaps are still clearly visible today and, of course, need serious elaboration.
Preliminary Results of 2022 for the Consolidated Budgets of the Subjects of the Russian Federation. Adaptation or Crisis?
Authors: Lykova L. N.
Published: March 2023

The consolidated budgets of the subjects the Russian Federation execution in 2022 was carried out in conditions of massive sanctions pressure on the domestic economy, significant fluctuations in prices on world commodity markets, radical changes in economic logistics chains and an increase in the need for budget expenditures. In January-November 2022, the growth of regional budget revenues only slightly lagged behind the rate of inflation. At the same time, in a number of regions with a significant role of ferrous metallurgy and related mining industries, there was a marked reduction in tax revenues to regional budgets, and in some cases to the consolidated budget of the country. Receipts of corporate income tax during the year had a pronounced tendency to decrease. Budget revenues from personal income tax played a stabilizing role. The growth in the need for expenditures of regional budgets was reflected in their advanced growth in comparison with revenues. The result was a marked increase in the volume of public debt compared to the beginning of the year. At the same time, there has been a tendency to replace bank loans and bond loans with budget loans. Budget loans for some regions are beginning to play the role of instruments to compensate for the vertical financial imbalance.
Allogeneic Mesenchymal Stem Cells and Its Conditioned Medium as a Potential Adjuvant Therapy for COVID-19
Authors: Widowati Wahyu , Faried Ahmad , Kusuma Hanna Sari Widya , Hermanto Yulius , Harsono Ali Budi , Djuwantono Tono
Published: March 2023

Recent research has demonstrated that mesenchymal stem cells (MSCs) potentially benefit and enhance coronavirus disease (COVID-19) recovery. This benefit occurs via a mechanism that promotes viral clearance by phagocytes and macrophages. This action occurs through the innate (increase in IL-10 production and decrease in TNF-α and IL-12 production) and the adaptive immune system (decrease in IL-17 production, promote regulatory T cell proliferation and inhibit effectors T cell proliferation). MSCs are expected to act as an anti-inflammatory in the hyper-inflammatory state of COVID-19. MSCs enhance immune cell replacement that have been overwhelmed or have been lost due to cytokine storm. Although vaccines are the answer to this pandemic, MSCs can improve COVID-19 patients, especially in patients with chronic illnesses. The focus on keeping death-rates low is a great opportunity for MSCs-based therapy for severe or critically ill patients. MSCs and conditioned medium have the potential to serve as adjunctive therapy in preventing the body's overactive defense response or the so-called cytokine storm caused by COVID-19.Keywords: adjuvant therapy, COVID-19, mesenchymal stem cells, secretome
PROPRIEDADE INTELECTUAL, A INOVAÇÃO, E O SPINNER MODEL NO AGRONEGÓCIO
Authors: Mascarenhas Neto Aprígio Teles , Camargo Maria Emília
Published: March 2023

Trata-se de um estudo cujo tema é a propriedade intelectual, a inovação e no Spinner model no agronegócio. Tem o objetivo de traçar um panorama da relação entre a propriedade intelectual, a inovação e o Spinner model no setor do agronegócio. A metodologia adotada é da revisão sistemática com uma etapa bibliométrica, segundo as três leis da bibliometria, considerando os dez artigos mais citados na base Scopus entres os anos de 2013 a 2022. Os resultados mostram uma população de 129.362 achados com a amostra de 41 artigos, em que se observou a consonância com as três leis da bibliometria: poucos autores publicam mais, alguns periódicos se reptem e algumas palavras aparecem com mais frequência. A análise qualitativa permitiu selecionar 8 artigos que tratam mais especificamente dos temos, nos quais se destacam estudos que relacionam o agronegócio com inovação, e a inovação com o Spinner model. Esses estudos analisam a inovação tecnológica no campo, a necessidade de desenvolvimento sustentável, a criação e gestão do conhecimento e o método de avaliar a propensão a inovação das empresas, sejam grandes ou de pequeno porte. Os resultados mostram, também, que há muitos estudos que tratam dos quatros temas, porém, de forma isolada ou em conjugados com dois ou três, mas evidencia uma lacuna de estudos que abordam os quatros temas concomitantemente.
Recent Trends on Production Sources, Biosynthesis Pathways and Antiviral Efficacies of Artemisinin: A Candidate Phytomedicine against SARS-CoV-2
Authors: Hussain Adil
Published: March 2023

Background:

Artemisinin is a lactone sesquiterpenoid with an endo-peroxide bridge in the 1, 2, 3-trioxane structure employed for the treatment and management of lethal viral diseases. In the current review, emphasis has been given on the production of artemisinin from natural sources with biosynthesis pathways and potential antiviral activity.

Methods:

A wide-ranging inquiry on artemisinin was made electronically on the basis of articles published in peer-reviewed journals, abstracts, published in conference proceedings, government reports, preprints, books, Master’s and Ph.D. theses, etc. The research was carried out in different International scientific databases like Academic Search, Biological Abstracts, BIOSIS, BioOne Previews, CabDirect, Cochrane Library, Pubmed/Medline, GeoRef, Google Scholar, JSTOR, Journal Citation Reports, Mendeley, Publons, Researchgate, Scopus, SciELO, Springer Link, Science Direct, Web of Science, Taylor and Francis with particular keywords.

Results:

The evidence reviewed here indicates that out of the hundreds of species of the genus Artemisia mentioned in the literature, only 37 Artemisia species are reported to possess artemisinin naturally in their extracts with variable concentrations. This review further discusses the biosynthesis pathways and antiviral activities of artemisinin and its derivatives which have been used against more than 12 viral disease categories.

Conclusion:

On the whole, it is concluded that the primary natural sources of artemisinin and its derivatives are the Artemisia plants with antiviral activity, which are essential candidates for drug development against SARS-CoV-2 mainly from those Artemisia species screened for SARS-CoV- 2 infection.
BLDC Motor Drives with A Programmable Simplified C-Block to Generate Accurate Six-Step PWM Based on STM32 Microcontroller
Authors: Rusli Muhammad Rizani , Jati Mentari Putri , Nugroho Mochamad Ari Bagus , Qudsi Ony Asrarul , Sudiharto Indhana , Murdianto Farid Dwi , Wahjono Endro
Published: March 2023

This paper presents a digital implementation of a brushless direct current motor (BLDCM) drive with a six-step pulse width modulation (PWM) using a programmable simplified C-block based on the STM32 microcontroller. The implementation is conducted through the PSIM simulation platform, which is commonly used for power electronics and motor control. This approach combines the benefits of using a programmable simplified C-block for precise and flexible programming with the PWM concepts of the STM32 microcontroller. The PWM method used on the BLDCM drive is the unipolar upper PWM technique (H~PWM_L~ON). The performance of the PWM implementation is analyzed in detail, including the accuracy of the PWM generation using a Fast Fourier Transform (FFT), the gating of the IGBTs in the three-phase inverter, and the effect of the duty cycle on the BLDCM's speed, phase voltage, and phase current.
Strengthening nationalism and love of homeland in the global era through citizenship education as national defense education
Authors: Ali Yusuf Faisal
Published: March 2023

This study was to find out how to strengthen nationalism and love for the homeland in the global era through citizenship education as state defense education at STKIP Pasundan, Cimahi, West Java, Indonesia. This study used descriptive case study method, where data were obtained through interview, observation, and documentation studies in the field. The results showed that the strengthening of nationalism and love for the homeland in the global era through Citizenship Education as state defense education at STKIP Pasundan, Cimahi has been going well, proven by students’ awareness on nationalism and love for the homeland. In addition, through citizenship education courses, students were inhibited in strengthening nationalism and love for the homeland in the global era. This study could conclude that strengthening nationalism and love for the homeland in the global era through Citizenship Education as state defense education as to minimize behavior that did not reflect love for the homeland in the global era. Besides, the process of defending the country through Citizenship Education requires continuous effort.
Динамическая твердость и образование полос Портевена-Ле Шателье при ударном индентировании
Authors: Шибков А.А. , Золотов А.Е. , Денисов А.А. , Гасанов М.Ф. , Шибков Е.А. , Кочегаров С.С.
Published: March 2023

The effect of shock indentation on the formation and propagation of the Portevin-Le Chatelier deformation bands in an aluminum-magnesium alloy was studied experimentally using acoustic emission and high-speed video recording methods. Dynamic and nonlinear responses to shock indentation are revealed: the first include high values of dynamic hardness and local strain and loading rates, and the second - threshold and multiple nature of force and acoustic responses. It is shown that the bands of macrolocalized deformation represent a latent volumetric type of erosion damage, which reduces the mechanical stability and durability of the alloy.
Эволюция дефектов строения стекол SiO-=SUB=-2-=/SUB=--TiO-=SUB=-2-=/SUB=- при изменении концентрации TiO-=SUB=-2-=/SUB=- от нуля до разделения фаз
Authors: Щербаков И.П. , Нарыкова М.В. , Чмель А.Е.
Published: March 2023

The thermal expansion coefficient (TEC) of binary glasses SiO 2 -TiO 2 decreases as the TiO 2
concentration grows. At concentration of TiO 2 in the range of 4–6 mol% (in dependence of the
applied synthesis method) TEC becomes negative; at concentration of 8–11 mol% devitrification
occurs. A combination of photoluminescence (PL) and IR reflection techniques were applied for
studying the evolution of point and structural defects in the range of TiO 2 concentration from
zero to phase separation. The precision measurements of density showed its drop at TiO 2 content
of 7.9 mol% thus evidencing the conversion of glass into a polycrystalline substance consisting
of SiO 2 and TiO 2 crystallites. In the TiO 2 concentration range of compatibility of oxides, an
ensemble of point defects comprises ≡Si–O – and ≡Ti–O – centers as well as ≡Si–Si≡ and ≡Ti–Ti≡
neutral oxygen-vacancies. At the dopant concentration specific for phase separation (7.9 mol%),
the PL-active groups of Si–Ti go away, while the IR-detectable Si–O–Ti bridges remain
stable.
Uso y control de calidad de desinfectantes en esquemas de bioseguridad, para la prevención y contención de la marchitez por Fusarium Raza 4 Tropical
Authors: Betancourt Vásquez Mónica , Carmona Gutiérrez Sandra Lorena , Rodríguez Yzquierdo Gustavo Adolfo , Izquierdo García Luisa Fernanda , Soto Suárez Mauricio , Gómez Correa Juan Camilo , Zapata Henao Sebastián , González Ulloa Antonio José , Zuluaga Cruz Andrea Paola , Palacino Córdoba Jorge Hernán , Quintero Vargas Juliette Catalina , Castillo Urquiza Gloria Patricia , Dita Rodríguez Miguel Ángel
Published: March 2023

Uso y control de calidad de desinfectantes en esquemas de bioseguridad, para la prevención y contención de la marchitez por Fusarium Raza 4 Tropical resume el trabajo desarrollado por el ICA, AGROSAVIA y los gremios desde la llegada del marchitamiento por Foc R4T a plantaciones de banano en Colombia, con relación al uso correcto de desinfectantes, tanto en los esquemas de bioseguridad de las fincas afectadas y libres de la enfermedad, como en los puestos de control y lavado instalados por la Organización Nacional de Protección Fitosanitaria y los gremios. Se describen los principios de la dispersión del patógeno y las estrategias para mitigarlos; asimismo, se presenta un análisis de la evaluación microbiológica del funcionamiento de los esquemas de bioseguridad en el país. Además, se recoge de forma didáctica la información acerca de los métodos de evaluación de desinfectantes comerciales y los resultados validados para diferentes productos comerciales en Colombia. Los datos que contiene el manual se pueden usar en países de América Latina y El Caribe para el establecimiento de sus estrategias de bioseguridad, así como de los centros de investigación para las metodologías de evaluación de desinfectantes. Este documento se adapta a un público objetivo amplio: productores, asistentes técnicos, profesionales del agro y tomadores de decisiones, los cuales están involucrados con el sector bananero o platanicultor y orientados a la implementación de estrategias de bioseguridad en estos sistemas productivos.
Boletín de indicadores en ciencia, tecnología e innovación del sector agropecuario: indicadores de inversión pública nacional
Authors: Niño Vargas Edna Juliana , González Cerón Sandra Paola , Ramírez Beltrán Angélica María , Moreno Valderrama Maria Nancy , Uribe Galvis Claudia Patricia
Published: March 2023

La inversión pública agropecuaria proveniente del Fondo de Ciencia, Tecnología e Innovación del Sistema General de Regalías durante el periodo 2012 a 2020 es de $144.899,08 millones por año, lo que lo convierte en una de las principales fuentes sectoriales para desarrollar ACTI a través de los proyectos aprobados. No obstante lo anterior, el crecimiento desde su creación se ha reducido en casi 70 %, tendencia negativa que se mantuvo en 2020, cuyo aporte equivalente a $65.264,31 millones en 2015 representó 0,10 % en la participación respecto al PIBA; esto es una disminución de más de 80 % en recursos y 0,53 puntos en participación respecto al año anterior que como se mencionó genera un contraste entre el valor más alto (2019) y el más bajo (2020) hasta ahora reportados.
Boletín de indicadores de CTI del sector agropecuario: indicadores de inversión pública nacional y ejecución en ACTI del sector agropecuario
Authors: Niño Edna Juliana , González Sandra Paola , Ramírez Angélica María , Moreno Maria Nancy , Uribe Galvis Claudia Patricia
Published: March 2023

En inversión pública en ACTI agropecuaria, para 2019 se identificaron nueve (9) fuentes de financiación; AGROSAVIA (29,67 %), el Fondo de CTI del Sistema General de Regalías (28,28 %), el MADR (14,91 %), el SENA (10,76 %), los fondos parafiscales (10,29 %), la Agencia de Desarrollo Rural – ADR (2,6 %), la Unidad de Planificación Rural Agropecuaria – UPRA (1,65 %), la Autoridad Nacional de Acuicultura y Pesca – AUNAP (1,65 %) y el hoy Ministerio de Ciencia, Tecnología e Innovación (0,68 %).
Boletín de indicadores en ciencia, tecnología e innovación del sector agropecuario: capacidad del sector agropecuario
Authors: Niño Vargas Edna Juliana , González Cerón Sandra Paola , Ramírez Beltrán Angélica María , Moreno Valderrama Maria Nancy , Uribe Galvis Claudia Patricia
Published: March 2023

En 2020, se identificaron 38 activos entre bibliotecas centros de documentación especializados y museos, que brindaron servicio a los actores del sector agropecuario. Estas capacidades principalmente se ubican en Bogotá (8), Valle del Cauca (5), Antioquia (5), Caldas (5) y Risaralda (4) y se identifican 14 departamentos que no cuenta con estas capacidades sectoriales. Algunas de estas bibliotecas cuentan con cobertura a nivel nacional y regional a través de sus plataformas y canales virtuales.
Boletín Agroclimático Regional: mesa técnica agroclimática de Sucre junio 2022
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

La Mesa Técnica Agroclimática (MTA) de Sucre es un espacio de diálogo y análisis entre actores locales, nacionales y regionales, que busca comprender el posible comportamiento del clima a partir de información científica y conocimiento empírico, y generar recomendaciones para disminuir los riesgos asociados a la variabilidad climática en el sector agropecuario. En la última reunión celebrada el 7 de abril (modalidad presencial), se presentó la perspectiva climática para el trimestre abr – jun 2022 para Sucre. Con base en esta información, se discutieron impactos y recomendaciones para el sector agrícola. La información generada, se ha recopilado en el presente Boletín Agroclimático.
Boletín Agroclimático Regional: mesa técnica agroclimática de Boyacá octubre 2022
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

Este boletín es el resultado de la sesión de la Mesa Técnica Agroclimática ( realizada el 05 de octubre 2022 donde participaron diferentes expertos, técnicos y asociaciones de productores, con el apoyo de la FAO (Organización de las Naciones Unidas para la Alimentación y la Agricultura), Gobernación del Boyacá e IDEAM Esta iniciativa nacional, liderada por el Ministerio de Agricultura y Desarrollo Rural ( encamina a Colombia hacia una agricultura sostenible y adaptada al clima.
Boletín Agroclimático Nacional No.94
Authors:   https://repository.agrosavia.co/handle/20.500.12324/37782,   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

El Boletín Agroclimático Nacional es elaborado por la Mesa Técnica Agroclimática Nacional, liderada por el Ministerio de Agricultura y Desarrollo Rural-MADR, en alianza con la Organización de las Naciones Unidas para la Alimentación y la Agricultura – FAO y el Instituto de Hidrología, Meteorología y Estudios Ambientales-IDEAM y el apoyo de gremios del sector agropecuario, la academia, Secretarías de Agricultura, entre otros actores del orden nacional y local. Este documento contiene el análisis del comportamiento del clima en diferentes regiones del país y brinda recomendaciones para una mejor proyección de las actividades agrícolas y pecuarias.
Boletín Agroclimático Regional: mesa técnica agroclimática de Tolima julio 2022
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

La Mesa Técnica Agroclimática (MTA) de Tolima, es un espacio de diálogo y análisis entre actores locales, nacionales y regionales, que busca comprender el posible comportamiento del clima a partir de información científica y conocimiento empírico, y generar recomendaciones para disminuir los riesgos asociados a la variabilidad climática en el sector agropecuario.
Boletín Agroclimático Regional: mesa técnica agroclimática de Huila diciembre 2022
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

La Mesa Técnica Agroclimática ( de Huila, es un espacio de diálogo y análisis entre actores locales, regionales y nacionales que busca comprender el posible comportamiento del clima Se realizó esta reunión de carácter presencial donde se presentó la perspectiva climática para el trimestre diciembre de 2022 hasta febrero de 2023 para el departamento Con base en esta información se debatieron los posibles impactos y recomendaciones para el sector agropecuario de la región La información generada se ha recopilado en el presente Boletín Agroclimático para la edición correspondiente al mes de noviembre de 2022 a cargo de por La Universidad Surcolombiana el Ministerio de Agricultura y Desarrollo Rural ( FAO y el IDEAM y se presenta por cultivo o sector productivo.
Boletín Agroclimático Regional: mesa técnica agroclimática de Putumayo octubre 2022
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

La Mesa Técnica Agroclimática MTA de PUTUMAYO es un espacio de diálogo y análisis entre actores locales, nacionales y regionales, que busca comprender el posible comportamiento del clima a partir de información científica y conocimiento empírico, y generar recomendaciones para disminuir los riesgos asociados a la variabilidad climática en el sector agropecuario.
Boletín Agroclimático Nacional No.86
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

El Boletín Agroclimático Nacional es elaborado por la Mesa Técnica Agroclimática Nacional, liderada por el Ministerio de Agricultura y Desarrollo Rural-MADR, en alianza con el Instituto de Hidrología, Meteorología y Estudios Ambientales-Ideam y el apoyo de gremios del sector agropecuario, la academia, Secretarías de Agricultura, entre otros actores del orden nacional y local. Este documento contiene el análisis del comportamiento del clima en diferentes regiones del país y brinda recomendaciones para una mejor proyección de las actividades agrícolas y pecuarias.
Boletín Agroclimático Regional: mesa técnica agroclimática de Boyacá septiembre 2022
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

Este boletín es el resultado de la sesión de la Mesa Técnica Agroclimática (realizada el 08 de septiembre 2022,donde participaron diferentes expertos, técnicos y asociaciones de productores, con el apoyo de la FAO (Organización Organización de las Naciones Unidas para la Alimentación y la Agricultura), Gobernación del Boyacá el IDEAM. Esta iniciativa nacional, liderada por Ministerio de Agricultura de Colombia hacia una agricultura sostenible y adaptada al clima.
Boletín Agroclimático Regional: mesa técnica agroclimática de Sucre abril 2022
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

La Mesa Técnica Agroclimática (MTA) de Sucre es un espacio de diálogo y análisis entre actores locales, nacionales y regionales, que busca comprender el posible comportamiento del clima a partir de información científica y conocimiento empírico, y generar recomendaciones para disminuir los riesgos asociados a la variabilidad climática en el sector agropecuario. En la última reunión celebrada el 7 de abril (modalidad presencial), se presentó la perspectiva climática para el trimestre abr – jun 2022 para Sucre. Con base en esta información, se discutieron impactos y recomendaciones para el sector agrícola. La información generada, se ha recopilado en el presente Boletín Agroclimático.
Boletín Agroclimático Regional: mesa técnica agroclimática de Nariño septiembre 2022
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

La Mesa Técnica Agroclimática (MTA) de Nariño, es un espacio de diálogo y análisis entre actores locales, nacionales y regionales, que busca comprender el posible comportamiento del clima a partir de información científica y conocimiento empírico, y generar recomendaciones para disminuir los riesgos asociados a la variabilidad climática en el sector agropecuario.
Boletín Agroclimático Regional: mesa técnica agroclimática de Risaralda junio 2022
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

La Mesa Técnica Agroclimática (MTA) de Risaralda, es un espacio de diálogo y análisis entre actores locales, nacionales y regionales, que busca comprender el posible comportamiento del clima a partir de información científica y conocimiento empírico, y generar recomendaciones para disminuir los riesgos asociados a la variabilidad climática en el sector agropecuario.
Boletín Agroclimático Regional: mesa técnica agroclimática de Santander noviembre 2022
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

El cierre de la segunda temporada de lluvias en el departamento de Santander continua con probabilidad de lluvias por encima de los valores climatológicos para la época, a lo largo del departamento con mayor probabilidad en las provincias de Vélez, Comunera, Guanentá y García Rovira donde las lluvias fuertes en estas provincias se presentaran con actividad eléctrica frente al resto del departamento; y la probabilidad de un evento “La Niña” para el cierre del 2022 será una condición continuara con lluvias extremas en el departamento y que a su vez pueden alterar el comportamiento de la temperatura máxima y mínima dentro del departamento.
Boletín Agroclimático Regional: mesa técnica agroclimática de Putumayo agosto 2022
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Organización de las Naciones Unidas para la Alimentación y la Agricultura, Bogotá (Colombia),   Instituto de Hidrología, Meteorología y Estudios Ambientales, Bogotá (Colombia)
Published: March 2023

La Mesa Técnica Agroclimática (MTA) de Putumayo, es un espacio de diálogo y análisis entre actores locales, nacionales y regionales, que busca comprender el posible comportamiento del clima a partir de información científica y conocimiento empírico, y generar recomendaciones para disminuir los riesgos asociados a la variabilidad climática en el sector agropecuario.
A Novel Mobile App to Identify Patients With Multimorbidity in the Emergency Setting: Development of an App and Feasibility Trial
Authors: Rosen Claire Barthlow , Roberts Sanford Eugene , Syvyk Solomiya , Finn Caitlin , Tong Jason , Wirtalla Christopher , Spinks Hunter , Kelz Rachel Rapaport
Published: March 2023

Background

Multimorbidity is associated with an increased risk of poor surgical outcomes among older adults; however, identifying multimorbidity in the clinical setting can be a challenge.

Objective

We created the Multimorbid Patient Identifier App (MMApp) to easily identify patients with multimorbidity identified by the presence of a Qualifying Comorbidity Set and tested its feasibility for use in future clinical research, validation, and eventually to guide clinical decision-making.

Methods

We adapted the Qualifying Comorbidity Sets’ claims-based definition of multimorbidity for clinical use through a modified Delphi approach and developed MMApp. A total of 10 residents input 5 hypothetical emergency general surgery patient scenarios, common among older adults, into the MMApp and examined MMApp test characteristics for a total of 50 trials. For MMApp, comorbidities selected for each scenario were recorded, along with the number of comorbidities correctly chosen, incorrectly chosen, and missed for each scenario. The sensitivity and specificity of identifying a patient as multimorbid using MMApp were calculated using composite data from all scenarios. To assess model feasibility, we compared the mean task completion by scenario to that of the American College of Surgeons National Surgical Quality Improvement Program Surgical Risk Calculator (ACS-NSQIP-SRC) using paired t tests. Usability and satisfaction with MMApp were assessed using an 18-item questionnaire administered immediately after completing all 5 scenarios.

Results

There was no significant difference in the task completion time between the MMApp and the ACS-NSQIP-SRC for scenarios A (86.3 seconds vs 74.3 seconds, P=.85) or C (58.4 seconds vs 68.9 seconds,P=.064), MMapp took less time for scenarios B (76.1 seconds vs 87.4 seconds, P=.03) and E (20.7 seconds vs 73 seconds, P<.001), and more time for scenario D (78.8 seconds vs 58.5 seconds, P=.02). The MMApp identified multimorbidity with 96.7% (29/30) sensitivity and 95% (19/20) specificity. User feedback was positive regarding MMApp’s usability, efficiency, and usefulness.

Conclusions

The MMApp identified multimorbidity with high sensitivity and specificity and did not require significantly more time to complete than a commonly used web-based risk-stratification tool for most scenarios. Mean user times were well under 2 minutes. Feedback was overall positive from residents regarding the usability and usefulness of this app, even in the emergency general surgery setting. It would be feasible to use MMApp to identify patients with multimorbidity in the emergency general surgery setting for validation, research, and eventual clinical use. This type of mobile app could serve as a template for other research teams to create a tool to easily screen participants for potential enrollment.
Fluid Management for Critically Ill Patients with Acute Kidney Injury Receiving Kidney Replacement Therapy
Authors: Ledoux-Hutchinson Lawrence , Wald Ron , Malbrain Manu L.N.G. , Carrier François Martin , Bagshaw Sean M. , Bellomo Rinaldo , Adhikari Neill K.J. , Gallagher Martin , Silver Samuel A. , Bouchard Josée , Connor Jr Michael J. , Clark Edward G. , Côté Jean-Maxime , Neyra Javier A. , Denault André , Beaubien-Souligny William
Published: March 2023

Background

In critically ill patients receiving KRT, high ultrafiltration rates and persistent fluid accumulation are associated with adverse outcomes. The purpose of this international survey was to evaluate current practices and evidence gaps related to fluid removal with KRT in critically ill patients.

Methods

This was a multinational, web-based survey distributed by seven networks comprising nephrologists and intensivists. Physicians involved in the care of critically ill patients were invited to complete a 39-question survey about fluid management practices on KRT. The survey was distributed from September 2021 to December 2021.

Results

There were 757 respondents from 96 countries (response rate of 65%). Most respondents practiced adult medicine (89%) and worked in an academic center (69%). The majority (91%) reported aiming for a 0.5- to 2-L negative fluid balance per day when fluid removal is indicated, although there was important variability in what respondents considered a safe maximal target. Intensivists were more likely than nephrologists to use adjunct volume status assessment methods (i.e., ultrasound, hemodynamic markers, and intra-abdominal pressure), while nephrologists were more likely to deploy cointerventions aimed at improving tolerance to fluid removal (i.e., osmotic agents and low-temperature dialysate). There was a broad consensus that rapid decongestion should be prioritized when fluid accumulation is present, but the prevention of hypotension was also reported as a competing priority. A majority (77%) agreed that performing trials that compare fluid management strategies would be ethical and clinically relevant.

Conclusions

We have identified multiple areas of variability in current practice of fluid management for patients receiving KRT. Most nephrologists and intensivists agreed that several knowledge gaps related to fluid removal strategies should be investigated in future randomized controlled trials.
Design and Fabrication of Battery Operated 2-Wheeler Forklift
Authors: Madne Mr. Arvind , Lutade Samruddha , Ghuse Atharva , Bhowate Dhananjay , Fating Abhishek , Deshpande Ketan
Published: March 2023

Abstract: In today life there is wide of forklifts variety of forklifts from the large heavy loadings trucks to the one that works among narrow aisles forklifts have becomes one of basics transportation tools we use in our lives with all the forklifts in existence we find that there are some improvement that can be to bring forklifts to the better performance. Segway is a self-balancing transportation device with two wheel can operate in any level pedestrian environment In general the forklift can be defined as the machine capable of lifting heavy weights that is difficult for an ordinary human being to lift. It is similar to vehicle but a addition of two forks to lift the weight makes the difference. The operator using these forks can lift any heavy weight material on a click of button without any effort
Intervenções promotoras da capacidade de mentalização e função reflexiva: uma revisão integrativa
Authors: Pinheiro Schaefer Márcia , Becker Débora , Donelli Tagma Marina Schneider
Published: March 2023

Esta revisão integrativa da literatura objetivou sistematizar as possibilidades de intervenções promotoras da Capacidade de Mentalização (CM) e Função Reflexiva (FR), publicadas entre 2008 a 2019. Utilizou-se os descritores “reflective functioning OR mentalizing OR mentalization AND intervention” e incluiu-se artigos empíricos, disponibilizados em Inglês, Português ou Espanhol, provenientes de diferentes áreas. Analisou-se os dados através das categorias: objetivos; delineamentos; participantes; tipo de intervenção utilizada; instrumentos de avaliação da intervenção empregados; resultados. Encontrou-se 34 artigos que predominantemente verificaram a eficácia das intervenções, possuíam delineamento quantitativo, voltados para adultos e, ainda, intervenções com potencial para fortalecer os vínculos pais/cuidadores-criança. Concluiu-se sobre a necessidade de se desenvolver instrumentos específicos para avaliar FR e CM, estudos que abordem a realidade brasileira e, ainda, a sistematização desses conceitos, que na maioria dos artigos, se apresentaram como sinônimos.
¿Cómo contribuir, desde los nuevos escenarios sociales del siglo XXI, a una educación matemática accesible a las capacidades de todas y cada una de las personas?
Authors: Díaz Cynthia Marianela , Kovacic Gregorczuk María Victoria , Malik De Tchara Claudia , García Valeria Lourdes
Published: March 2023

El presente informe es realizado, en el marco del Proyecto de Investigación “Recursos didácticos para la enseñanza de la matemática en aulas inclusivas”, por recientes graduadas que comenzaron a participar del Proyecto siendo aún estudiantes de la carrera Profesorado para la Educación Primaria.

El proceso de formación de las estudiantes que participan en el Proyecto de Investigación mencionado articula la teoría y la práctica, es así que en el marco de la beca se apunta a que la tarea de investigación se sostenga con materiales que permitieran vincular el marco teórico objeto de investigación, las prácticas necesarias para el logro de los objetivos planteados y el abordaje metodológico que combina aspectos cualitativos y cuantitativos partiendo de la hipótesis central, que surge en el marco de una educación inclusiva y la contextualización del planteo de Cobeñas y Grimaldi (2017): ¿qué podemos pensar y hacer desde la Universidad, como colectivo de docentes, para enseñar Matemática en Aulas Inclusivas? En este contexto se constituye un espacio de producción y reflexión colectiva y se apunta a la incorporación de conocimientos acerca de las nuevas configuraciones de los escenarios sociales en el siglo XXI, que contribuyan a la problematización de la realidad social y educativa.

Reconociendo que el campo de la Educación Inclusiva está cubierto de incertidumbres, disputas y contradicciones, el análisis que se desarrolla busca dar respuesta a cómo contribuir a que la Educación Matemática sea accesible a las capacidades de todos/as los/as niños, jóvenes y adultos/as, pensando primeramente en el cómo incluir y cómo enseñar con equidad y justicia basada en la igualdad y valía de todos los seres humanos.
Thermal sensation models for environmental parameters testing
Authors: Kralikova Ruzena , Lumnitzer Ervin
Published: March 2023

Currently, there are various complex models that are used to predict the thermal load, or thermal comfort of the employee with different scales for evaluating the feeling of warmth or of cold, with the help of which it is possible not only to speed up the evaluation of the thermal load but also to make it more precise. With the help of thermal manikins, it is possible to simulate human reactions to heat and humidity conditions. The article deals with the possibilities of using thermal manikins as a useful aid in measuring heat exchange between the environment and the human body, testing thermal stress, etc. These tools will then be available for use by the industry to develop more efficient thermal comfort systems.
Optimal Hamiltonian simulation for time-periodic systems
Authors: Mizuta Kaoru , Fujii Keisuke
Published: March 2023

The implementation of time-evolution operators U(t), called Hamiltonian simulation, is one of the most promising usage of quantum computers. For time-independent Hamiltonians, qubitization has recently established efficient realization of time-evolution U(t)=e−iHt, with achieving the optimal computational resource both in time t and an allowable error ε. In contrast, those for time-dependent systems require larger cost due to the difficulty of handling time-dependency. In this paper, we establish optimal/nearly-optimal Hamiltonian simulation for generic time-dependent systems with time-periodicity, known as Floquet systems. By using a so-called Floquet-Hilbert space equipped with auxiliary states labeling Fourier indices, we develop a way to certainly obtain the target time-evolved state without relying on either time-ordered product or Dyson-series expansion. Consequently, the query complexity, which measures the cost for implementing the time-evolution, has optimal and nearly-optimal dependency respectively in time t and inverse error ε, and becomes sufficiently close to that of qubitization. Thus, our protocol tells us that, among generic time-dependent systems, time-periodic systems provides a class accessible as efficiently as time-independent systems despite the existence of time-dependency. As we also provide applications to simulation of nonequilibrium phenomena and adiabatic state preparation, our results will shed light on nonequilibrium phenomena in condensed matter physics and quantum chemistry, and quantum tasks yielding time-dependency in quantum computation.
Surface Dangling Bond Effect on Magnetic Property of Mn-doped ZnO Nanowires
Authors: N Tsogbadrakh , Choi Eun-Ae , Lee Woo-Jin , K. J Chang
Published: March 2023

We investigate the magnetic properties of Mn-doped ZnO nanowires (NWs) using the local spin density approximation (LSDA) and the LSDA+U approach, where U represents the on-site Coulomb interaction. In carrier-free (Zn,Mn)O NWs, the majority Mn ta states are fully occupied, leading to an antiferromagnetic ground state. We examine the effect of additional p-type doping on the ferromagnetism by considering surface O dangling bonds. Localized hole carriers are generated in the majority ta states and promote a ferromagnetic ordering via double exchange interactions, similar to the trend of bulk (Zn,Mn)O. The ferromagnetic coupling tends to increase with increasing of the hole carrier density.