bluuebunny/crossref_metadata_2025 huggingface dataset:
PIN1 Maintains Redox Balance via the c-Myc/NRF2 Axis to Counteract Kras-Induced Mitochondrial Respiratory Injury in Pancreatic Cancer Cells
Authors: Liang Chen , Shi Si , Liu Mingyang , Qin Yi , Meng Qingcai , Hua Jie , Ji Shunrong , Zhang Yuqing , Yang Jingxuan , Xu Jin , Ni Quanxing , Li Min , Yu Xianjun
Published: October 2018

Kras is a decisive oncogene in pancreatic ductal adenocarcinoma (PDAC). PIN1 is a key effector involved in the Kras/ERK axis, synergistically mediating various cellular events. However, the underlying mechanism by which PIN1 promotes the development of PDAC remains unclear. Here we sought to elucidate the effect of PIN1 on redox homeostasis in Kras-driven PDAC. PIN1 was prevalently upregulated in PDAC and predicted the prognosis of the disease, especially Kras-mutant PDAC. Downregulation of PIN1 inhibited PDAC cell growth and promoted apoptosis, partially due to mitochondrial dysfunction. Silencing of PIN1 damaged basal mitochondrial function by significantly increasing intracellular ROS. Furthermore, PIN1 maintained redox balance via synergistic activation of c-Myc and NRF2 to upregulate expression of antioxidant response element driven genes in PDAC cells. This study elucidates a new mechanism by which Kras/ERK/NRF2 promotes tumor growth and identifies PIN1 as a decisive target in therapeutic strategies aimed at disturbing the redox balance in pancreatic cancer.

Significance:

This study suggests that antioxidation protects Kras-mutant pancreatic cancer cells from oxidative injury, which may contribute to development of a targeted therapeutic strategy for Kras-driven PDAC by impairing redox homeostasis.
Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma
Authors: Rahrmann Eric P. , Wolf Natalie K. , Otto George M. , Heltemes-Harris Lynn , Ramsey Laura B. , Shu Jingmin , LaRue Rebecca S. , Linden Michael A. , Rathe Susan K. , Starr Timothy K. , Farrar Michael A. , Moriarity Branden S. , Largaespada David A.
Published: October 2018

Follicular lymphoma and diffuse large B-cell lymphoma (DLBCL) are the most common non-Hodgkin lymphomas distinguishable by unique mutations, chromosomal rearrangements, and gene expression patterns. Here, it is demonstrated that early B-cell progenitors express 2′,3′-cyclic-nucleotide 3′ phosphodiesterase (CNP) and that when targeted with Sleeping Beauty (SB) mutagenesis, Trp53R270H mutation or Pten loss gave rise to highly penetrant lymphoid diseases, predominantly follicular lymphoma and DLBCL. In efforts to identify the genetic drivers and signaling pathways that are functionally important in lymphomagenesis, SB transposon insertions were analyzed from splenomegaly specimens of SB-mutagenized mice (n = 23) and SB-mutagenized mice on a Trp53R270H background (n = 7) and identified 48 and 12 sites with statistically recurrent transposon insertion events, respectively. Comparison with human data sets revealed novel and known driver genes for B-cell development, disease, and signaling pathways: PI3K–AKT–mTOR, MAPK, NFκB, and B-cell receptor (BCR). Finally, functional data indicate that modulating Ras-responsive element-binding protein 1 (RREB1) expression in human DLBCL cell lines in vitro alters KRAS expression, signaling, and proliferation; thus, suggesting that this proto-oncogene is a common mechanism of RAS/MAPK hyperactivation in human DLBCL.

Implications:

A forward genetic screen identified new genetic drivers of human B-cell lymphoma and uncovered a RAS/MAPK–activating mechanism not previously appreciated in human lymphoid disease. Overall, these data support targeting the RAS/MAPK pathway as a viable therapeutic target in a subset of human patients with DLBCL.
Atypical Manifestation of Disseminated Sporotrichosis in an AIDS Patient
Authors: Ferreira Thiago Amparo , Trope Beatriz Moritz , Barreiros Glória , Quintela Danielle Carvalho , Ramos-e-Silva Marcia
Published: October 2018

Sporotrichosis is an infection caused by fungi of the Sporothrix complex. The clinical lymphocutaneous presentation corresponds to the great majority of cases. With the increased incidence of sporotrichosis in the State of Rio de Janeiro, Brazil, atypical clinical forms have been reported with increasing frequency, usually associated with immunosuppression. We report the case of a 47-year-old female, with HIV and disseminated sporotrichosis, presenting molluscum-like skin lesions, as well as lung, nasal, and oral mucosa involvement. We also report the first demonstration of culture of Sporothrix in scales of the skin lesion, a fact not identified in the consulted literature.
Cumulative Sum Analysis of the Learning Curve for Modified Retroperitoneoscopic Living-Donor Nephrectomy
Authors: Zhu Dongdong , Hong Peng , Zhu Jun , Ye Xin , Chen Yuke , Fan Yu , Zhang Zhongyuan , Shen Cheng , Yu Wei , Jin Jie
Published: October 2018

Objectives: To introduce our modified retroperitoneoscopic living-donor nephrectomy (RPLDN) techniques and estimate the learning curve. Methods: We retrospectively evaluated 121 consecutive donors who underwent modified RPLDN performed by a single surgeon. While the surgeon controlled the renal vessels, one hand was inserted through an abdominal incision for assistance. The kidney was manually retrieved through the abdominal incision. The learning curve was evaluated using the cumulative sum (CUSUM) method, which was a graphical method showing changes in individual surgical performance. Results: The mean operating time and warm ischemic time (WIT) were 129.4 min and 154.5 s, respectively. The mean estimated blood loss (EBL) was 44.4 mL. Regarding intraoperative complications, no open conversions or blood transfusions were required. The CUSUM learning curve included the following 3 unique phases: phase 1 (the initial 32 cases), representing the initial learning curve; phase 2 (the middle 38 cases), representing expert competence; and phase 3 (the final 51 cases), representing mastery. Conclusions: Our modified method has the advantages of a short operating time, an optimized WIT, a low EBL, and acceptable complication rates. The surgeon completed the initial learning phase of RPLDN after 32 cases and could effectively perform RPLDN after 70 cases.
2-O-Methylmagnolol Induces Apoptosis and Inhibits IL-6/STAT3 Signaling in Oral Squamous Cell Carcinoma
Authors: Wang Tong-Hong , Fang Jia-You , Wu Shu-Ju , Liu Yi-Wen , Chan Chieh-Wen , Chuang Shih-Yi , Chen Chi-Yuan 
Published: October 2018

Background/Aims: 2-O-methylmagnolol (MM1), a derivative of magnolol bearing one methoxy moiety, has been shown to display improved anti-tumor activity against skin cancers. In this study, we examined the anti-tumor effects of magnolol and MM1 on oral squamous cell carcinoma (OSCC). Methods: Trypane blue staining and clonogenic assays were performed to determine the cytotoxic effects of magnolol and MM1 in OSCC cells. Migration and matrigel invasion assays were carried out to examine the metastasis effects of magnolol and MM1 in OSCC cells. IL6-stimulation, Western blot, and immunohistochemistry were used to investigate the IL-6/STAT3 signaling and apoptosis. A bioluminescent mouse model of orthotopically implanted SAS cells was used to determine the anti-tumor activity of MM1 in vivo. Results: MM1 displays greater activity than magnolol on affecting the cytotoxicity, migration, and invasion of OSCC cells cultured in vitro. The improved anti-tumor activity of MM1 was shown to associate with its greater activity to inhibit STAT3 signaling and to induce apoptosis in the OSCC. In addition, we presented evidence that MM1 is effective in inhibiting the growth of orthotopic implanted OSCC cells in vivo. Conclusion: Our data indicate that MM1 displays greater anti-tumor activity than magnolol in OSCC and is an attractive agent to be further explored for its potential clinical application.
Activation of Nrf2 by Sulforaphane Inhibits High Glucose-Induced Progression of Pancreatic Cancer via AMPK Dependent Signaling
Authors: Chen Xin , Jiang Zhengdong , Zhou Cancan , Chen Ke , Li Xuqi , Wang Zheng , Wu Zheng , Ma Jiguang , Ma Qingyong , Duan Wanxing
Published: October 2018

Background/Aims: Sulforaphane (SFN) is known for its potent bioactive properties, such as anti-inflammatory and anti-tumor effects. However, its anti-tumor effect on pancreatic cancer is still poorly understood. In the present study, we explored the therapeutic potential of SFN for pancreatic cancer and disclosed the underlying mechanism. Methods: Panc-1 and MiaPaca-2 cell lines were used in vitro. The biological function of SFN in pancreatic cancer was measured using EdU staining, colony formation, apoptosis, migration and invasion assays. Reactive oxygen species (ROS) production was measured using 2’-7’-Dichlorofluorescein diacetate (DCF-DA) fluorometric analysis. Western blotting and immunofluorescence were used to measure the protein levels of p-AMPK and epithelial-mesenchymal transition (EMT) pathway-related proteins, and cellular translocation of nuclear factor erythroid 2-related factor 2 (Nrf2). Nude mice and transgenic pancreatic cancer mouse model were used to measure the therapeutic potential of SFN on pancreatic cancer. Results: SFN can inhibit pancreatic cancer cell growth， promote apoptosis, curb colony formation and temper the migratory and invasion ability of pancreatic cancer cells. Mechanistically, excessive ROS production induced by SFN activated AMPK signaling and promoted the translocation of Nrf2, resulting in cell viability inhibition of pancreatic cancer. Pretreatment with compound C, a small molecular inhibitor of AMPK signaling, reversed the subcellular translocation of Nrf2 and rescued cell invasion ability. With nude mice and pancreatic cancer transgenic mouse, we identified SFN could inhibit tumor progression, with smaller tumor size and slower tumor progression in SFN treatment group. Conclusion: Our study not only elucidates the mechanism of SFN-induced inhibition of pancreatic cancer in both normal and high glucose condition, but also testifies the dual-role of ROS in pancreatic cancer progression. Collectively, our research suggests that SFN may serve as a potential therapeutic choice for pancreatic cancer.
The Effects of miR-195-5p/MMP14 on Proliferation and Invasion of Cervical Carcinoma Cells Through TNF Signaling Pathway Based on Bioinformatics Analysis of Microarray Profiling
Authors: Li Min , Ren Chun-Xia , Zhang Jian-Mei , Xin Xiao-Yan , Hua Teng , Wang Hong-Bin , Wang Hong-Bo
Published: October 2018

Background/Aims: This study is aimed at identification of miR-195-5p/MMP14 expression in cervical cancer (CC) and their roles on cell proliferation and invasion profile of CC cells through TNF signaling pathway in CC. Methods: Microarray analysis, gene set enrichment analysis (GSEA) and DAVID were used to analyze differentially expressed miRNAs, mRNAs and signaling pathways. MiR-195-5p and MMP14 expression levels in CC cell were determined by qRT-PCR. Western blot was employed to measure MMP14 and TNF signaling pathway-relating protein level. Luciferase reporter system was used to confirm the targeting relationship between MMP14 and miR-195-5p. Cell proliferation and invasion was respectively deeded by CCK8, transwell. In vivo experiment was carried out to study the impact of MMP14 and miR-195-5p on CC development in mice. Results: The microarray analysis and the results of qRT-PCR determined that miR-195-5p was under-expressed and MMP14 was over-expressed in CC cells. GSEA and DAVID analysis showed that TNF signaling pathway was regulated by miR-195-5p/MMP14 and activated in cervical carcinoma cells. The miR-195-5p and MMP14 have a negative regulation relation. In vivo experiment found that down-regulated MMP14 and up-regulated miR-195-5p suppressed the tumor development. Conclusion: Our results suggest that MMP14 is a direct target of miR-195-5p, and down-regulated MMP14 and up-regulated miR-195-5p suppressed proliferation and invasion of CC cells by inhibiting TNF signaling pathway.
Circulating Long Noncoding RNAs as Biomarkers for Predicting Head and Neck Squamous Cell Carcinoma
Authors: Yao Yao , Chen Xinyuan , Lu Shuai , Zhou Chao , Xu Guolong , Yan Zhongyi , Yang Jianrong , Yu Tonghua , Chen Wei , Qian Yichun , Ding Shounian , Tang Junwei , Chen Yun , Zhang Yuan
Published: October 2018

Background/Aims: The anatomical complexity of the head and neck region and the lack of sufficiently specific and sensitive biomarkers often lead to the diagnosis of head and neck squamous cell carcinoma (HNSCC) at advanced stages. To identify novel biomarkers for early diagnosis of primary HNSCC through a minimally invasive method, we investigated circulating long noncoding RNA (lncRNA) levels in plasma of HNSCC patients. Methods: The global lncRNA expression profiles of HNSCC patients were measured using microarray and next-generation RNA-sequencing (RNA-seq) data from both circulating and tissue samples. The diagnosis prediction model based on the lncRNA signatures and clinical features was evaluated by multi-stage validation and risk score analysis. Results: The data showed that 432 lncRNA transcripts were differentially expressed by fold changes of > 4 in circulating samples and 333 in tissues samples, respectively. Only 12 lncRNAs consistently emerged in these two kinds of samples. After the risk score analysis including a multistage validation, we identified three lncRNAs, namely, HOXA11-AS, LINC00964 and MALAT1, which were up-regulated in the plasma of HNSCC patients compared with those in healthy controls with merged areas under the curve (AUCs) in training and validation sets of 0.925 and 0.839, respectively. Conclusion: HOXA11-AS, LINC00964 and MALAT1 might be potential circulating biomarkers for the early detection of HNSCC in the future.
Triflamp, a snake venom metalloproteinase, reduces neutrophil-platelet adhesion through proteolysis of PSGL-1 but not glycoprotein Ibα
Authors: Tseng Yu-Lun , Lee Chia-Jung , Hsu Chun-Chieh , Huang Tur-Fu
Published: October 2018

Triflamp, a metalloproteinase isolated from Trimeresurus flavoviridis, inhibits heterotypic adhesion between platelets and neutrophils. Coincubation studies demonstrate that direct interaction of triflamp with neutrophils is sufficient to inhibit the formation of neutrophil-platelet complexes. Its anti-adhesive effect is in a concentrationand incubation time-dependent manner. Triflamp reduces the expression of P-selectin glycoprotein ligand-1 (PSGL-1) on neutrophils and glycoprotein (GP) Ibα on platelets as probed by flow cytometry and Western blot. Moreover, triflamp disrupts P-selectin-mediated adhesion by cleaving PSGL-1 from the neutrophil surface.There are obvious differences regarding PSGL-1 proteolysis by triflamp and cathepsin G. Besides the NH2-terminus of PSGL-1, other sites are truncated by triflamp. The inhibitory effect of triflamp on PSGL-1 expression was prevented by pretreatment with a metalloproteinase inhibitor, phenanthroline. However, triflamptreated platelets fully keep the ability for binding to PAFor fMLP-stimulated neutrophils. Our results indicate that degradation of platelet GPIbα by triflamp does not interfere with neutrophil-platelet adhesion. Its effect on neutrophil PSGL-1 appears to be a critical factor for its inhibition on neutrophilplatelet interaction.
Pharmacokinetic Modelling to Predict FVIII:C Response to Desmopressin and Its Reproducibility in Nonsevere Haemophilia A Patients
Authors: Schütte Lisette , van Hest Reinier , Stoof Sara , Leebeek Frank , Cnossen Marjon , Kruip Marieke , Mathôt Ron
Published: October 2018

Background Nonsevere haemophilia A (HA) patients can be treated with desmopressin. Response of factor VIII activity (FVIII:C) differs between patients and is difficult to predict.

Objectives Our aims were to describe FVIII:C response after desmopressin and its reproducibility by population pharmacokinetic (PK) modelling.

Patients and Methods Retrospective data of 128 nonsevere HA patients (age 7–75 years) receiving an intravenous or intranasal dose of desmopressin were used. PK modelling of FVIII:C was performed by nonlinear mixed effect modelling. Reproducibility of FVIII:C response was defined as less than 25% difference in peak FVIII:C between administrations.

Results A total of 623 FVIII:C measurements from 142 desmopressin administrations were available; 14 patients had received two administrations at different occasions. The FVIII:C time profile was best described by a two-compartment model with first-order absorption and elimination. Interindividual variability of the estimated baseline FVIII:C, central volume of distribution and clearance were 37, 43 and 50%, respectively. The most recently measured FVIII:C (FVIII-recent) was significantly associated with FVIII:C response to desmopressin (p < 0.001). Desmopressin administration resulted in an absolute FVIII:C increase of 0.47 IU/mL (median, interquartile range: 0.32–0.65 IU/mL, n = 142). FVIII:C response was reproducible in 6 out of 14 patients receiving two desmopressin administrations.

Conclusion FVIII:C response to desmopressin in nonsevere HA patients was adequately described by a population PK model. Large variability in FVIII:C response was observed, which could only partially be explained by FVIII-recent. FVIII:C response was not reproducible in a small subset of patients. Therefore, monitoring FVIII:C around surgeries or bleeding might be considered. Research is needed to study this further.
Treatment Challenges in Venous Thromboembolism: An Appraisal of Rivaroxaban Studies
Authors: Weitz Jeffrey , Khorana Alok
Published: October 2018

Venous thromboembolism (VTE) presents a continuing clinical burden to healthcare systems and there are patient groups for whom VTE management is challenging. Depending on the patient profile, the optimal duration of anticoagulation for VTE treatment can be unclear. EINSTEIN CHOICE was a Phase III, randomized, double-blind trial that compared the safety and efficacy of two once-daily (od) doses of the direct, oral factor Xa inhibitor rivaroxaban (20 and 10 mg) with acetylsalicylic acid (ASA; 100 mg daily) for prevention of recurrent VTE. Extended therapy with rivaroxaban at either dose was more effective than ASA at preventing recurrent VTE without increasing bleeding risk. Another group that is challenging to treat in the context of VTE is patients with cancer-associated thrombosis. Cancer is associated with a hypercoagulable state, while cancer treatment itself may increase VTE risk. Evidence supporting the use of non-vitamin K antagonist oral anticoagulants in patients with cancer is growing through specifically designed studies. Cancer Associated thrombosis—expLoring soLutions for patIentS through Treatment and prevention with rivarOxaban (CALLISTO) is an international research program exploring the role of rivaroxaban for the prevention and treatment of cancer-associated thrombosis. Here, we present overviews of three CALLISTO studies: PRO-LAPS II, CASTA-DIVA and COSIMO. Currently available and anticipated results from studies in a variety of patients at risk of or with VTE will provide valuable insights and seek to optimize future VTE management.
Effects of a Community Population Health Initiative on Blood Pressure Control in Latinos
Authors: Langabeer James R. , Henry Timothy D. , Perez Aldana Carlos , DeLuna Larissa , Silva Nora , Champagne‐Langabeer Tiffany
Published: October 2018

Background

Hypertension remains one of the most important, modifiable cardiovascular risk factors. Yet, the largest minority ethnic group (Hispanics/Latinos) often have different health outcomes and behavior, making hypertension management more difficult. We explored the effects of an American Heart Association–sponsored population health intervention aimed at modifying behavior of Latinos living in Texas.

Methods and Results

We enrolled 8071 patients, and 5714 (65.7%) completed the 90‐day program (58.5 years ±11.7; 59% female) from July 2016 to June 2018. Navigators identified patients with risk factors; initial and final blood pressure (
BP
) readings were performed in the physician's office; and interim home measurements were recorded telephonically. The intervention incorporated home
BP
monitoring, fitness and nutritional counseling, and regular follow‐up. Primary outcomes were change in systolic
BP
and health‐related quality of life. Using a univariate paired‐samples pre–post design, we found an average 5.5% (7.6‐mm Hg) improvement in systolic
BP
(139.1 versus 131.5, t=10.32,
P
<0.001). Quality of life measured by the European quality of life 5‐dimension visual analog scale improved from 0.79 to 0.82 (t=31.03,
P
<0.001). After multivariate regression analyses, improvements in quality of life and overall body mass index were significantly associated with reductions in systolic
BP
.

Conclusions

A noninvasive, population health initiative that encourages routine engagement in patients’ own BP control was associated with improvements in systolic BP and quality of life for this largely Latino community.
Change of Kidney Function Is Associated With All‐Cause Mortality and Cardiovascular Diseases: Results From the Kailuan Study
Authors: Guo Yidan , Cui Liufu , Ye Pengpeng , Li Junjuan , Wu Shouling , Luo Yang
Published: October 2018

Background

Current evaluation about the relationship of sequential change in estimated glomerular filtration rate (
eGFR
) and clinical outcomes are still inconsistent. We aimed to investigate the association between the change in kidney function over time and the risk of all‐cause mortality and cardiovascular disease.

Methods and Results

This prospective cohort including 37 691 participants aged ≥45 years used data from the Kailuan Health Registry. The relationship of the annual percentage and absolute change in
eGFR
and outcomes were analyzed with Cox proportional regression. The participants were stratified according to the quintiles distribution of the percentage annual change in
eGFR
(Q1–Q5). After adjusting for baseline covariates including initial
eGFR
, participants with annual
eGFR
decline were at significantly greater risk for all‐cause mortality (Q1: hazard ratio, 1.22 [95% confidence interval, 1.04–1.43]; Q2: 1.19 [1.01–1.40]) than noted for patients in Q3. Cardiovascular disease risk was also significantly higher in participants with annual
eGFR
decline (Q1 and Q2). No significantly increased risk of adverse outcomes was noted for patients with annual
eGFR
increased groups (Q4 and Q5). When considering the absolute
eGFR
annual change rate (no/mild/rapid decline), we obtained similar results in chronic kidney disease participants, whereas non–chronic kidney disease participants had less pronounced association of
eGFR
decline with cardiovascular disease, though not with mortality.

Conclusions

A decline in
eGFR
over time is associated with higher risk for all‐cause mortality and cardiovascular disease independent of initial
eGFR
and other known risk factors at baseline. Our data support the serial evaluation of change in kidney function as a better prognostic indicator than single
eGFR
assessments.
New synonyms and typifications in Chionoloma tenuirostre (Pottiaceae, Bryophyta)
Authors: ALONSO MARTA , JIMÉNEZ JUAN A. , CANO MARÍA J.
Published: October 2018

Names within Chionoloma tenuirostre are evaluated for proper taxonomic position. A total of 20 names are treated as synonyms, among them, 10 are here synonymised for the first time (Hyophila acutiuscula, Leptodontium subintegrum, Oxystegus cylindricus var. filifer, Trichostomum angustifolium, T. fallax, T. fallax f. minutum, T. fragilifolium, T. prionodon, T. siamense and T. uncinifolium) and three names are excluded from the synonymy (Barbula wollei, Tortula cylindrotheca and Trichostomum burmense). In order to maintain nomenclatural stability, the typification of 12 names is discussed and lectotypes are designated.
A new species of Chimarra from China (Trichoptera, Philopotamidae) with description of its larva
Authors: HU YAN-LI , WANG BEI-XIN , SUN CHANG-HAI
Published: October 2018

The adult male and larva of a new species in the genus Chimarra Stephens, Chimarra paramonorum n. sp., are described, diagnosed, and illustrated based on the specimens collected in Zhejiang Province, China. The larva and adult male were associated by mtCOI gene sequences. The male can be separated from C. monorum and C. thienemanni mainly by small preanal appendages and by wrinkled, hairless endotheca. The larva of the new species can be separated from other congeners by a combination of characters including the notch on the anterior margin of the frontoclypeus, the teeth of the mandibles, and the length of the seta-bearing process of each forecoxa. The larval description is the first for Chimarra in China.
Impact of Gauge Representative Error on a Radar Rainfall Uncertainty Model
Authors: Dai Qiang , Yang Qiqi , Zhang Jun , Zhang Shuliang
Published: October 2018

In modeling the radar rainfall uncertainty, rain gauge measurement is generally regarded as the areal “true” rainfall. However, the inconsistent scales between radar and gauge may introduce a new uncertainty (also known as gauge representative uncertainty), which is erroneously identified as radar rainfall uncertainty and therefore called pseudouncertainty. It is crucial to comprehend what percentage of the estimated radar rainfall uncertainty actually stems from such pseudouncertainty rather than radar rainfall itself. For this reason, based on a fully formulated radar rainfall uncertainty model, this study aims to explore how the gauge representative error affects the distribution, spatial dependence, and temporal dependence of hourly accumulated radar rainfall uncertainty, and consequently affects the produced radar rainfall uncertainty band. Three group scenarios that delineate various degrees of gauge representative errors were designed to configure and run the uncertainty model. In the setting of a long-term analysis (almost 7 years) of the Brue catchment in the United Kingdom, we found that the gauge representative error affected the simulation of the marginal distribution of radar rainfall error, and had a considerable effect on temporal dependence estimation of radar rainfall uncertainty. The spread of the rainfall uncertainty band decreased with the growth of the gauge density in a radar pixel. The scenario with the lowest representative error only had 78% uncertainty spread of the scenario that has the largest error. This indicated there was a large impact of the representative error on radar rainfall uncertainty models. It is hoped that more catchments with diverse climate and geographical conditions and more radar data with various spatial scales could be explored by the research community to further investigate this crucial issue.
Extratropical Influence on 200-hPa Easterly Acceleration over the Western Indian Ocean Preceding Madden–Julian Oscillation Convective Onset
Authors: Gahtan Jennifer , Roundy Paul
Published: October 2018

The onset of Madden–Julian oscillation (MJO) deep convection often occurs over the western Indian Ocean and has upper-tropospheric circulation precursors that consist of eastward-circumnavigating tropical easterlies and subtropical cyclonic Rossby gyres near eastern Africa. Moreover, the evolution of the large-scale circulation and its ability to reduce subsidence may be necessary for the initial development of organized deep convection. To better understand the evolution of the circulation precursors and their interaction with convective onset, this paper analyzes the upper-tropospheric zonal momentum budget using a regional index based on the temporal progression of the meridional structure of intraseasonal outgoing longwave radiation anomalies over eastern Africa and the western Indian Ocean. The circumnavigating intraseasonal easterly acceleration produces upper-level divergence when it reaches the western extent of a region of intraseasonal westerlies and may provide a forcing for the in-phase midtropospheric upward vertical motion. For about three-quarters of the identified cases, the easterly acceleration over the western Indian Ocean is a response to the zonal pressure gradient over the region. In the composite, the negative pressure gradient force may be initially induced by the injection of negative geopotential height anomalies from the extratropics of both hemispheres to the tropics over eastern Africa, though tropically circumnavigating and local signals may also contribute to the easterly acceleration, especially in the days following convective onset.
Inhomogeneous Mixing in Lagrangian Cloud Models: Effects on the Production of Precipitation Embryos
Authors: Hoffmann Fabian , Yamaguchi Takanobu , Feingold Graham
Published: October 2018

Although small-scale turbulent mixing at cloud edge has substantial effects on the microphysics of clouds, most models do not represent these processes explicitly, or parameterize them rather crudely. This study presents a first use of the linear eddy model (LEM) to represent unresolved turbulent mixing at the subgrid scale (SGS) of large-eddy simulations (LESs) with a coupled Lagrangian cloud model (LCM). The method utilizes Lagrangian particles to provide the trajectory of air masses within LES grid boxes, while the LEM is used to redistribute these air masses among the Lagrangian particles based on the local features of turbulence, allowing for the appropriate representation of inhomogeneous to homogeneous SGS mixing. The new approach has the salutary effect of mitigating spurious supersaturations. At low turbulence intensities, as found in the early stages of an idealized bubble cloud simulation, cloud-edge SGS mixing tends to be inhomogeneous and the new approach is shown to be essential for the production of raindrop embryos. At higher turbulence intensities, as found in a field of shallow cumulus, SGS mixing tends to be more homogeneous and the new approach does not significantly alter the results, indicating that a grid spacing of 20 m may be sufficient to resolve all relevant scales of inhomogeneous mixing. In both cases, droplet in-cloud residence times are important for the production of precipitation embryos in the absence of small-scale inhomogeneous mixing, either naturally due to strong turbulence or artificially as a result of coarse resolution or by not using the LEM as an SGS model.
A Nonstationary ENSO–NAO Relationship Due to AMO Modulation
Authors: Zhang Wenjun , Mei Xuebin , Geng Xin , Turner Andrew G. , Jin Fei-Fei
Published: October 2018

Many previous studies have demonstrated a high uncertainty in the relationship between El Niño–Southern Oscillation (ENSO) and the North Atlantic Oscillation (NAO). In the present work, decadal modulation by the Atlantic multidecadal oscillation (AMO) is investigated as a possible cause of the nonstationary ENSO–NAO relationship based on observed and reanalysis data. It is found that the negative ENSO–NAO correlation in late winter is significant only when ENSO and the AMO are in phase (AMO+/El Niño and AMO−/La Niña). However, no significant ENSO-driven atmospheric anomalies can be observed over the North Atlantic when ENSO and the AMO are out of phase (AMO−/El Niño and AMO+/La Niña). Further analysis indicates that the sea surface temperature anomaly (SSTA) in the tropical North Atlantic (TNA) plays an essential role in this modulating effect. Because of broadly analogous TNA SSTA responses to both ENSO and the AMO during late winter, a warm SSTA in the TNA is evident when El Niño occurs during a positive AMO phase, resulting in a significantly weakened NAO, and vice versa when La Niña occurs during a negative AMO phase. In contrast, neither the TNA SSTA nor the NAO shows a prominent change under out-of-phase combinations of ENSO and AMO. The AMO modulation and the associated effect of the TNA SSTA are shown to be well reproduced by historical simulations of the HadCM3 coupled model and further verified by forced experiments using an atmospheric circulation model. These offer hope that similar models will be able to make predictions for the NAO when appropriately initialized.
Impact of GVF Derivation Methods on Noah Land Surface Model Simulations and WRF Model Forecasts
Authors: Fang Li , Zhan Xiwu , Hain Christopher R. , Yin Jifu , Liu Jicheng
Published: October 2018

Green vegetation fraction (GVF) plays a crucial role in the atmosphere–land water and energy exchanges. It is one of the essential parameters in the Noah land surface model (LSM) that serves as the land component of a number of operational numerical weather prediction models at the National Centers for Environmental Prediction (NCEP) of NOAA. The satellite GVF products used in NCEP models are derived from a simple linear conversion of either the normalized difference vegetation index (NDVI) from the Advanced Very High Resolution Radiometer (AVHRR) currently or the enhanced vegetation index (EVI) from the Visible Infrared Imaging Radiometer Suite (VIIRS) planned for the near future. Since the NDVI or EVI is a simple spectral index of vegetation cover, GVFs derived from them may lack the biophysical meaning required in the Noah LSM. Moreover, the NDVI- or EVI-based GVF data products may be systematically biased over densely vegetated regions resulting from the saturation issue associated with spectral vegetation indices. On the other hand, the GVF is physically related to the leaf area index (LAI), and thus it could be beneficial to derive GVF from LAI data products. In this paper, the EVI-based and the LAI-based GVF derivation methods are mathematically analyzed and are found to be significantly different from each other. Impacts of GVF differences on the Noah LSM simulations and on weather forecasts of the Weather Research and Forecasting (WRF) Model are further assessed. Results indicate that LAI-based GVF outperforms the EVI-based one when used in both the offline Noah LSM and WRF Model.
The right thalamic glutamate level correlates with functional connectivity with right dorsal anterior cingulate cortex/middle occipital gyrus in unmedicated obsessive–compulsive disorder: A combined fMRI and 1H-MRS study
Authors: Chen Yongjun , Meng Ziyu , Zhang Zongfeng , Zhu Yajing , Gao Rui , Cao Xuan , Tan Ling , Wang Zhen , Zhang Haiyin , Li Yao , Fan Qing
Published: October 2018

Objective:

The imbalance in neurotransmitter and neuronal metabolite concentration within cortico-striato-thalamo-cortical (CSTC) circuit contributes to obsessive–compulsive disorder’s (OCD) onset. Previous studies showed that glutamate mediated upregulation of resting-state activity in healthy people. However, there have been few studies investigating the correlational features between functional and neurochemical alterations in OCD.

Methods:

We utilize a combined resting-state functional magnetic resonance imaging (rs-fMRI) and proton magnetic resonance spectroscopy (1H-MRS) approach to investigate the altered functional connectivity (FC) in association with glutamatergic dysfunction in OCD pathophysiology. Three regions of interest are investigated, i.e., medial prefrontal cortex and bilateral thalamus, for seed-based whole-brain FC analysis as well as MRS data acquisition. There are 23 unmedicated adult OCD patients and 23 healthy controls recruited for brain FC analysis. Among them, 12 OCD and 8 controls are performed MRS data acquisition.

Results:

Besides abnormal FC within CSTC circuit, we also find altered FCs in large-scale networks outside CSTC circuit, including occipital area and limbic and motor systems. The decreased FC between right thalamus and right middle occipital gyrus (MOG) is correlated with glutamatergic signal within right thalamus in OCD patients. Moreover, the FC between right thalamus and right dorsal anterior cingulate cortex (dACC) is associated with glutamate level in right thalamus, specifically in patient’s group. Finally, the FC between right thalamus and right MOG is correlated with patient’s Yale–Brown Obsessive Compulsive Scale (YBOCS) compulsion and total scores, while the right thalamic glutamatergic signal is associated with YBOCS-compulsion score.

Conclusion:

Our findings showed that the coupled intrinsic functional–biochemical alterations existed both within CSTC circuit and from CSTC to occipital lobe in OCD pathophysiology.
Anger as a Mediator Between Peer Victimization and Deviant Behavior in South Korea: A Cross-Cultural Application of General Strain Theory
Authors: Oh Gyeongseok , Connolly Eric J.
Published: October 2018

Little is known about the longitudinal effect of peer victimization on deviant behavior in non-Western cultural contexts and the mediating role of theoretically relevant variables, such as anger, on this association. The current study aimed to address this gap by analyzing data from a nationally representative sample of South Korean youth. Peer victimization was found to increase risk for anger and deviant behavior. Anger accounted for 27.06% of the total direct effect of peer victimization experienced during late childhood on deviant behavior during early adolescence. Results from the current study provide support for the cross-cultural application of general strain theory to help explain the longitudinal link between peer victimization and deviant behavior in a non-Western context such as South Korea.
The Influence of Type of Defense Counsel on Prosecutorial and Judicial Decision Making in Domestic Violence Cases
Authors: Kutateladze Besiki Luka , Leimberg Anna
Published: October 2018

This study examines the influence of the type of defense counsel on prosecutorial and judicial decisions in domestic violence cases. We found that the type of defense counsel mattered more in sentencing compared with previous decision points. Cases handled by private attorneys were less likely to experience charge reductions at screening and be dismissed. However, decision patterns are reversed postarraignment, where charges start to decrease at a higher rate for cases represented by private counsel. Defendants represented by private lawyers were less likely to plead guilty, but they were also markedly less likely to face incarceration.
Effect of interlayer carbon fiber dispersion on the low-velocity impact performance of woven flax-carbon hybrid composites
Authors: Ravandi M , Kureemun U , Banu M , Teo WS , Tong Liu , Tay TE , Lee HP
Published: October 2018

This work investigates the effects of interlayer hybrid fiber dispersion on the impact response of carbon-flax epoxy hybrid laminates at low carbon volume fractions, and benchmarks the mechanical performance enhancement against the non-hybrid flax epoxy. Five hybrid laminate stacking sequences with similar carbon-to-flax weight ratio were fabricated and subjected to low-velocity impact at three different energy values, generating non-perforated and perforated damage states. A virtual drop-weight impact test that models intralaminar failure based on continuum damage mechanics approach, and delamination using cohesive elements, was also implemented to evaluate the material behavior and damage development in the composites. Simulation results were then verified against experimental data. Results suggested that positioning stiffer carbon plies at the impact face does not necessarily lead to enhancement of the hybrid's impact properties. On the contrary, flax plies at the impacted side lead to significant improvement in impact resistance compared to the non-hybrid flax composite with similar thickness. Results of finite element analysis showed that carbon plies play a significant role in the hybrid laminate's energy absorption characteristics due to lower failure strain.
Effects of carbon nanotubes additive on thermal conductivity and thermal energy storage properties of a novel composite phase change material
Authors: Sarı Ahmet , Biçer Alper , Hekimoğlu Gökhan
Published: October 2018

Fatty acids are commonly preferred as phase change materials for passive solar thermoregulation due to their several advantageous latent heat thermal energy storage (LHTES) properties. However, further storage container requirement of fatty acids against leakage problem during heating period and also low thermal conductivity significantly limit their application fields. To overcome these drawbacks of capric acid–stearic acid eutectic mixture as phase change material, it was first impregnated with expanded vermiculite clay by melting/blending method and then doped with carbon nanotubes. The effects of carbon nanotubes additive on the chemical/morphological structures and LHTES properties of the composite phase change material and thermal enhanced change phase change materials were investigated by scanning electron microscope, Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry and thermogravimetric analysis analysis techniques. The differential scanning calorimetry results showed that the form-stable composite phase change materials and thermal enhanced composite phase change materials have melting temperatures in the range of 24.35–24.64℃ and latent heat capacities between 76.32 and 73.13 J/g. Thermal conductivity of the composite phase change materials was increased as 83.3, 125.0 and 258.3% by carbon nanotubes doping 1, 3 and 5 wt%. The heat charging and discharging times of the thermal enhanced -composite phase change materials were reduced appreciably due to the enhanced thermal conductivity without notably influencing their LHTES properties. Furthermore, the thermal cycling test and thermogravimetric analysis findings proved that all fabricated composites had admirable thermal durability, cycling LHTES performance and chemical stability.
Genome Editing: A New Horizon for Oral and Craniofacial Research
Authors: Yu N. , Yang J. , Mishina Y. , Giannobile W.V.
Published: October 2018

Precise and efficient genetic manipulations have enabled researchers to understand gene functions in disease and development, providing a platform to search for molecular cures. Over the past decade, the unprecedented advancement of genome editing techniques has revolutionized the biological research fields. Early genome editing strategies involved many naturally occurring nucleases, including meganucleases, zinc finger nucleases, and transcription activator-like effector-based nucleases. More recently, the clustered regularly interspaced short palindromic repeats (CRISPR) / CRISPR-associated nucleases (CRISPR/Cas) system has greatly enriched genetic manipulation methods in conducting research. Those nucleases generate double-strand breaks in the target gene sequences and then utilize DNA repair mechanisms to permit precise yet versatile genetic manipulations. The oral and craniofacial field harbors a plethora of diseases and developmental defects that require genetic models that can exploit these genome editing techniques. This review provides an overview of the genome editing techniques, particularly the CRISPR/Cas9 technique, for the oral and craniofacial research community. We also discuss the details about the emerging applications of genome editing in oral and craniofacial biology.
Emotion Words Modulate Early Conflict Processing in a Flanker Task: Differentiating Emotion-Label Words and Emotion-Laden Words in Second Language
Authors: Zhang Juan , Teo Timothy , Wu Chenggang
Published: October 2018

Emotion words modulate conflict processing, even at an early stage (i.e., N200). However, the previous studies implicitly mixed emotion-label words and emotion-laden words together and mostly concentrated on first language (L1) rather than on second language (L2). The current study aimed to investigate whether L2 negative emotion-label words, negative emotion-laden words, and neutral words would affect conflict processing in a flanker task by using event-related potential (ERP) measurements. Twenty Chinese-English bilinguals completed a modified flanker task to decide the color of the target words. The results revealed that only L2 negative emotion-label words elicited larger left frontal N200 in the incongruent condition than in the congruent condition. No significant difference between the two conditions was observed for L2 negative emotion-laden words or neutral words. This research demonstrated that L2 emotion words could also modulate early conflict processing, at least for L2 negative emotion-label words.
Extracurricular Activities and Disadvantaged Youth: A Complicated—But Promising—Story
Authors: Heath Ryan D. , Anderson Charity , Turner Ashley Cureton , Payne Charles M.
Published: October 2018

Increased political and research interest in extracurricular activities stems, in part, from the claim that these programs especially benefit disadvantaged youth. However, little literature has synthesized studies across types of disadvantage to assess this claim. This article reviews research on disadvantaged youth in extracurricular programs, including differences by gender, socioeconomic status, race/ethnicity, and immigrant status. Our review reveals a promising, if complicated, picture. Although disadvantaged youth are less likely to participate in extracurricular activities, they often experience greater benefits, depending on the risk status and activity type. Evidence clearly supports expanding access to extracurricular programs for disadvantaged youth.
Meet Me at the Corner: The Intersection of Literacy Instruction and Race for Urban Education
Authors: Croom Marcus
Published: October 2018

This article focuses on some languaging that occurred during a race event within a literacy lesson involving a racially White, female adult and a racially Black, male child. I analyze an excerpt from this race event, illustrating an approach to race analysis which might be useful to the field of urban education. I ask, “What is the racial significance of this teacher’s language during literacy instruction?” In other words, I am pursuing what a practice theory of race might allow us to know when this alternative account of race is used to examine an observed episode of teaching. Accordingly, I introduce practice of race theory (PRT) and report my race critical discourse analysis of one teacher’s observed instructional language. Findings are relevant to literacy instruction, and future literacy research is recommended, especially in urban education.
Some Methods for the Analysis of Event Sequence Data from Multiple Respondents
Authors: Martin John Levi , Murphy James P.
Published: October 2018

The analysis of sequence data poses a great challenge; existing methods for the comparison of sequences take what theoretical grounding they have from other fields (most importantly, genetics). We argue that set theory provides a way of establishing the relations between sequences that has a natural application to the case in which the sequences are orderings of a set of events, all compatible with an underlying partial order shared by multiple respondents. We also examine the possibility that observed differences in sequence data come from a stochastic process in which some events are poorly ordered because respondents cannot discriminate between them. We show that such methods shed light on several quantities that have been of interest to researchers, such as the degree of consensus within a group as to ideal sequences, the degree of respondent accuracy in reporting, and the degree to which plans and reality coincide.