bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of enamel surface after bracket debonding and adhesive removal with six different methods
Authors: Arbutina Adriana , Arapovic-Savic Marijana , Umicevic-Davidovic Mirjana , Kuzmanovic-Radman Irena , Nedeljkovic Nenad , Glisic Branislav
Published: January 2020

Introduction/Objective. After an orthodontic brackets debonding procedure it is necessary to remove any residual adhesive from the tooth surface, as this is a common cause of enamel damage. The aim of this study is to evaluate the enamel surface after the application of six different methods of adhesive removal following brackets debonding, as well as to compare the duration of these procedures. Methods. For the purpose of this study, 245 human premolars were extracted as part of the orthodontic treatment. Metal brackets were bonded to 210 human premolars with the Aspire adhesive system. After the debonding of brackets, the samples were divided into six groups according to the adhesive removal method applied: tapered fissure tungsten carbide bur, round tungsten carbide bur, composite bur, abrasive disc, adhesive removing pliers, and ultrasonic scaler. Out of 245 premolars, 35 served as a control group. The duration of adhesive removal was recorded. Enamel damages were estimated according to the enamel surface index on the scanning electron microscopy images. Results. Maximum preservation of the enamel surface was accomplished by using a composite bur (1.08). The application of abrasive disc was significantly less time-consuming in comparison to the application of a composite bur (p < 0.01) and an ultrasonic scaler (p < 0.01). Conclusion. The most harmful for the enamel surface was the use of an ultrasonic scaler as well as a round tungsten carbide bur. Adhesive removal done by an abrasive disc thus proved one of the least damaging and the least time-consuming methods.
Perivascular Adipose Tissue Controls Insulin-Stimulated Perfusion, Mitochondrial Protein Expression, and Glucose Uptake in Muscle Through Adipomuscular Arterioles
Authors: Turaihi Alexander H. , Serné Erik H. , Molthoff Carla F.M. , Koning Jasper J. , Knol Jaco , Niessen Hans W. , Goumans Marie Jose T.H. , van Poelgeest Erik M. , Yudkin John S. , Smulders Yvo M. , Jimenez Connie R. , van Hinsbergh Victor W.M. , Eringa Etto C.
Published: January 2020

Insulin-mediated microvascular recruitment (IMVR) regulates delivery of insulin and glucose to insulin-sensitive tissues. We have previously proposed that perivascular adipose tissue (PVAT) controls vascular function through outside-to-inside communication and through vessel-to-vessel, or “vasocrine,” signaling. However, direct experimental evidence supporting a role of local PVAT in regulating IMVR and insulin sensitivity in vivo is lacking. Here, we studied muscles with and without PVAT in mice using combined contrast-enhanced ultrasonography and intravital microscopy to measure IMVR and gracilis artery diameter at baseline and during the hyperinsulinemic-euglycemic clamp. We show, using microsurgical removal of PVAT from the muscle microcirculation, that local PVAT depots regulate insulin-stimulated muscle perfusion and glucose uptake in vivo. We discovered direct microvascular connections between PVAT and the distal muscle microcirculation, or adipomuscular arterioles, the removal of which abolished IMVR. Local removal of intramuscular PVAT altered protein clusters in the connected muscle, including upregulation of a cluster featuring Hsp90ab1 and Hsp70 and downregulation of a cluster of mitochondrial protein components of complexes III, IV, and V. These data highlight the importance of PVAT in vascular and metabolic physiology and are likely relevant for obesity and diabetes.
Lamin C Counteracts Glucose Intolerance in Aging, Obesity, and Diabetes Through β-Cell Adaptation
Authors: de Toledo Marion , Lopez-Mejia Isabel C. , Cavelier Patricia , Pratlong Marine , Barrachina Célia , Gromada Xavier , Annicotte Jean-Sébastien , Tazi Jamal , Chavey Carine
Published: January 2020

Aging-dependent changes in tissue function are associated with the development of metabolic diseases. However, the molecular connections linking aging, obesity, and diabetes remain unclear. Lamin A, lamin C, and progerin, products of the Lmna gene, have antagonistic functions on energy metabolism and life span. Lamin C, albeit promoting obesity, increases life span, suggesting that this isoform is crucial for maintaining healthy conditions under metabolic stresses. Because β-cell loss during obesity or aging leads to diabetes, we investigated the contribution of lamin C to β-cell function in physiopathological conditions. We demonstrate that aged lamin C only–expressing mice (LmnaLCS/LCS) become obese but remain glucose tolerant due to adaptive mechanisms including increased β-cell mass and insulin secretion. Triggering diabetes in young mice revealed that LmnaLCS/LCS animals normalize their fasting glycemia by both increasing insulin secretion and regenerating β-cells. Genome-wide analyses combined to functional analyses revealed an increase of mitochondrial biogenesis and global translational rate in LmnaLCS/LCS islets, two major processes involved in insulin secretion. Altogether, our results demonstrate for the first time that the sole expression of lamin C protects from glucose intolerance through a β-cell–adaptive transcriptional program during metabolic stresses, highlighting Lmna gene processing as a new therapeutic target for diabetes treatment.
The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition
Authors: Capozzi Megan E. , Coch Reilly W. , Koech Jepchumba , Astapova Inna I. , Wait Jacob B. , Encisco Sara E. , Douros Jonathan D. , El Kimberly , Finan Brian , Sloop Kyle W. , Herman Mark A. , D’Alessio David A. , Campbell Jonathan E.
Published: January 2020

Glucagon is classically described as a counterregulatory hormone that plays an essential role in the protection against hypoglycemia. In addition to its role in the regulation of glucose metabolism, glucagon has been described to promote ketosis in the fasted state. Sodium–glucose cotransporter 2 inhibitors (SGLT2i) are a new class of glucose-lowering drugs that act primarily in the kidney, but some reports have described direct effects of SGLT2i on α-cells to stimulate glucagon secretion. Interestingly, SGLT2 inhibition also results in increased endogenous glucose production and ketone production, features common to glucagon action. Here, we directly test the ketogenic role of glucagon in mice, demonstrating that neither fasting- nor SGLT2i-induced ketosis is altered by interruption of glucagon signaling. Moreover, any effect of glucagon to stimulate ketogenesis is severely limited by its insulinotropic actions. Collectively, our data suggest that fasting-associated ketosis and the ketogenic effects of SGLT2 inhibitors occur almost entirely independent of glucagon.
PENINGKATAN PRODUKTIVITAS PADI HIBRIDA MELALUI PEMBERIAN PUPUK N DENGAN SISTEM RATUN DI LAHAN PASANG SURUT
Authors: Gribaldi Gribaldi , Nurlaili Nurlaili , Danial Ekawati
Published: January 2020

Penelitian bertujuan untuk mengetahui peningkatan produktivitas padi hibrida dengan sistem ratun pada beberapa dosis dan aplikasi pupuk N di Lahan pasang surut.  Penelitian  dilaksanakan pada bulan April - Agustus 2019 di Lahan Percobaan Dinas Pertanian Kabupaten Banyuasin, dengan menggunakan Rancangan Acak Kelompok Faktorial (RAKF) yang diulang  tiga kali.  Faktor faktor yang diteliti terdiri dari; Perlakuan dosis pupuk (N): dosis 90 kg N/ha (N1),  dosis 135 kg N/ha (N2). Perlakuan aplikasi pupuk (A): aplikasi pupuk ½ dosis saat tanam + ½ dosis fase primordia (A1); aplikasi pupuk 1/3 dosis saat tanam + 1/3 dosis fase primordia + 1/3 dosis saat panen (A2), aplikasi pupuk 1/3 dosis saat tanam + 1/3 dosis fase primordia + 1/6 dosis saat panen + 1/6 dosis pada  21 hari setelah panen (A3). Hasil penelitian menunjukan, dosis dan aplikasi pupuk N berpengaruh terhadap  peningkatan produktivitas padi hibrida di lahan pasang surut, Peningkatan produktivitas padi hibrida pada beberapa dosis dan aplikasi pupuk N berkisar 37.3-63.2 persen.  Peningkatan produktivitas tertinggi didapat pada perlakuan  pemupukan dosis 135 kgN/ha dan aplikasinya 1/3 dosis saat tanam+1/3 dosis saat primordia dan 1/3 dosis saat panen, yaitu  sebesar 63,2 persen atau dengan hasil gabah sebesar  7,28 ton/ha.
Efektifitas Pembelajaran Berbasis Masalah dalam Meningkatkan Sikap Kepedulian Lingkungan Siswa (Studi Kasus pada Permasalahan Lingkungan Global)
Authors: Agustian Dita
Published: January 2020

Penelitian ini dilakukan atas dasar keprihatinan terhadap perilaku masyarakat yang terkesan acuh terhadap permasalahan lingkungan yang terjadi di lingkungan sekitarnya, serta adanya harapan untuk membentuk generasi muda yang peduli dan memiliki etika lingkungan yang lebih baik. Penelitian ini bertujuan untuk mengetahui efektifitas pembelajaran berbasis masalah dalam meningkatkan sikap kesadaran lingkungan siswa khususnya pada kasus-kasus permasalahan lingkungan global. Metode penelitian ini menggunakan Quasi Experimental dengan desain One Group Pretest-Posttest Design dan pengambilan sampel secara Purposive Sampling. Data diperoleh melalui skala sikap kepedulian lingkungan berdasarkan tingkatan ranah sikap menurut Krathwohl, Bloom, dan Masia. Hasil menunjukkan bahwa model pembelajaran berbasis masalah melalui penggunaan permasalahan lingkungan global, efektif dalam meningkatkan sikap kepedulian lingkungan siswa. Hal ini ditunjukkan dengan nilai indeks gain sebesar 0,52 yang termasuk kategori sedang dan rerata nilai sikap di atas Kriteria Ketuntasan Minimal (KKM) yaitu 81,4. Indikator sikap kesadaran lingkungan yang memiliki nilai paling tinggi yaitu peduli atau sadar dengan nilai 95, dan yang paling rendah yaitu komitmen dengan nilai 55. Hasil penelitian ini diharapkan bisa diimplementasikan di dalam kegiatan pembelajaran sehari-hari untuk membiasakan siswa supaya memiliki kepedulian dan karakter yang baik terhadap lingkungan di sekitarnya
Kemampuan Guru Biologi dalam Pengimplementasian Kurikulum 2013 Ditinjau dari Kompetensi Pedagogik
Authors: Harfian Binar Azwar Anas
Published: January 2020

Penelitian ini bertujuan untuk mengetahui tingkat kemampuan guru biologi dalam mengimplementasikan Kurikulum 2013 di sekolah ditinjau dari kompetensi pedagogik di SMA Negeri Kabupaten Sleman. Penelitian ini menggunakan metode survei dengan sampel lima orang guru dari populasi sebanyak tujuh orang guru. Teknik pengambilan sampelnya dengan purposive sampling. Instrumen yang digunakan adalah angket, pedoman wawancara, pedoman observasi, dan dokumentasi. Analisis data dengan teknik analisis deskriptif kuantitatif dan kualitatif. Hasil penelitiannya adalah tingkat kemampuan guru biologi dalam mengimplementasikan Kurikulum 2013 ditinjau dari kompetensi pedagogik di SMA Negeri Kabupaten Sleman yaitu satu orang guru dengan kategori sangat mampu, tiga orang guru dengan kategori mampu, serta satu orang guru dengan kategori cukup mampu.
Kuliah Lapangan Terpadu Berbasis Inkuiri untuk Meningkatkan Penguasaan Konsep Mahasiswa Pendidikan Biologi
Authors: Ibrahim Yusuf
Published: January 2020

Kuliah lapangan merupakan pengalaman belajar penting bagi mahasiswa calon guru biologi. Tujuan dari penelitian ini adalah untuk mengetahui  peningkatan penguasaan konsep mahasiswa melalui pengalaman belajar kuliah lapangan terpadu berbasis inkuiri. Subjek penelitian dalam penelitian ini adalah mahasiswa calon guru biologi di salah satu iniversitas swasta di kota Bandung (n=30). Instrumen yang digunakan dalam penelitian ini adalah tes penguasaan konsep. Metodologi penelitian yang digunakan dalam penelitian ini adalah metode kuasi ekperimen dengan desain one group postes postes design. Hasil penelitian menunjukan bahwa implementasi pengalaman belajar kuliah lapangan terpadu berbasis inkuiri dapat meningkatkan penguasaan konsep mahasiswa calon guru biologi (N-gain=0,62). Pengalaman belajar melalui kuliah lapangan terpadu berbasis inkuiri dapat membantu mahasiswa meningkatkan penguasaan konsepnya.
Analisis Kecerdasan Ekologis Mahasiswa Calon Guru Biologi Melalui Model Pembelajaran Berbasis Masalah dengan Bantuan Diagram Vee
Authors: Chaidir Diki Muhammad
Published: January 2020

Latar belakang penelitian ini adalah kegiatan pembelajaran lebih terfokus kepada pemahaman teori saja serta berpusat kepada dosen (teacher centered oriented), sehingga mengakibatkan masih rendahnya kemampuan berpikir tingkat tinggi serta masih banyak yang membuang sampah sembarangan yang menandakan masih kurangnya kecerdasan ekologis. Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran berbasis masalah dengan bantuan diagram Vee terhadap kecerdasan ekologis mahasiswa calon guru biologi pada mata kuliah Ekologi Tumbuhan. Pengukuran kecerdasan ekologis menggunakan tes pilihan ganda dengan jumlah lima pilihan yang disesuaikan dengan indikator kecerdasan ekologis. Dari hasil penelitian dapat disimpulkan bahwa implementasi model pembelajaran berbasis masalah dengan bantuan diagram Vee pada kelas eksperimen memiliki perbedaan hasil kecerdasan ekologis dibandingkan mahasiswa calon guru biologi dengan kelas kontrol yang proses pembelajarannya menggunakan model pembelajaran langsung, model pembelajaran berbasis masalah dengan bantuan diagram Vee mempunyai rata-rata N-Gain yang lebih baik dibandingkan dengan model pembelajaran konvensional terhadap kecerdasan ekologis mahasiswa calon guru biologi. Persentase peningkatan kecerdasan ekologis tertinggi pada kelas eksperimen terdapat pada indikator pengetahuan tentang prediksi permasalahan lingkungan di masa yang akan datang.
Penggunaan Metode Pembelajaran Outdoor Learning untuk Meningkatkan Hasil Belajar Siswa pada Subkonsep Vertebrata
Authors: Maulana Gina ganjar , Saputra Jusep
Published: January 2020

Tujuan dari penelitian ini adalah untuk mendapatkan informasi tentang metode pembelajaran Outdoor Learning untuk meningkatkan hasil belajar siswa, khususnya sub konsep vertebrata dalam proses pembelajaran. Metode penelitian kuasi eksperimental dengan rancangan kelompok kontrol kuasi eksperimental tanpa kuadrat (tidak ada rancangan kelompok kontrol yang setara) yang melibatkan setidaknya dua kelompok. Subjek adalah siswa SMA Pasundan 3 kelas Bandung X-1 dan X-2 dengan jumlah siswa pada masing-masing 30 orang. Data diperoleh dengan hasil pretes dan postes. Instrumen dalam penelitian ini adalah uji pilihan ganda pilihan sebanyak 20 pertanyaan. Berdasarkan hasil penilitian, metode pembelajaran Outdoor Learning dapat meningkatkan hasil belajar
Implementasi E-learning Berbasis Assessment For Learning Untuk Meningkatkan Performa Belajar Mahasiswa
Authors: Ardiansyah Ryan , Diella Dea
Published: January 2020

Penelitian ini bertujuan untuk mengungkap pengaruh implemenetasi E-learning berbasis Assessment for learning terhadap performa belajar mahasiswa. Performa belajar mahasiswa terdiri atas hasil belajar, motivasi belajar dan aktifitas (keaktifan) belajar yang meliputi aktifitas bertanya dan memberikan tanggapan dalam proses diskusi di kelas. Metode yang digunakan untuk mencapai tujuan penelitian adalah metode true eksperimen. Desain yang akan digunakan yaitu posttest only control group – design. Kelompok eksperimen dan kontrol akan mendapatkan posttest. Partisipan penelitian ini adalah perwakilan mahasiswa semester 4 yang mengontrak matakuliah evaluasi dan asesmen. Instrumen penelitian yang digunakan meliputi soal kognitif untuk menjaring data hasil belajar, angket motivasi untuk menjaring data motivasi , dan lembar observasi keaktifan. Temuan penelitian ini menunjukkan bahwa elearning berbasis assessmen for learning (AfL) berupa pemberian feedback menunjukkan pengaruh yang signifikan terhadap hasil belajar, motivasi dan keaktifan. Perlakuan terhadap hasil belajar memiliki effect size sebesar 0.60 yang berarti sedang.
PENGARUH PENDEKATAN KONSTRUKTIVISME TERHADAP HASIL BELAJAR IPA DI KELAS V SDN KOTA PADANG
Authors: Adriantoni Adri Antoni , Syafitri Altika
Published: January 2020

Abstrak: Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan pendekatan  onstruktivisme terhadap hasil belajar IPA di kelas V SD Kota Padang. Populasi penelitian ini adalah siswa kelas V SD Kota Padang dengan teknik penentuan sampel secara jenuh, yaitu pengambilan anggota sampel dari populasi dilakukan secara acak tanpa memperhatikan strata yang ada dalam populasi, kelas A sebagai kelas eksperimen menggunakan pendekatan konstruktivisme, dan kelas B sebagai kelas control menggunakan pembelajaran  konvensional, dengan rancangan penelitian posttest only control design. Pengumpulan data dalam penelitian ini adalah menggunakan tes hasil belajar berupa soal objektif sebanyak 16 butir soal, data yang diperoleh dianalisis dengan menggunakan uji t. berdasarkan hasil penelitian, terlihat bahwa  dan  dan taraf signifikan 5%. Berdasarkan pengujian  maka hipotesis atau H1 diterima.  Dari hasil penelitian terbukti bahwa  penggunaan pendekatan konstruktivisme memberikan pengaruh terhadap hasil belajar IPA  di kelas V SD Kota Padang  Tahun ajaran 2017/2018.Kata Kunci: Pengaruh, Pendekatan Konstruktivisme, Hasil Belajar IPA Abstrac: This study aims to determine the effect of using constructivism approach to science learning outcomes in class V SDN 33 Kalumbuk Padang City. The population of this research is the students of grade V SDN 33 Kalumbuk Padang with sample determination technique is saturated sample, that is taking of sample member from the population is done randomly without  considering  the strata that exist in population, class A as experiment class using constructivism approach and class B as control using conventional learning, with a post-test only control design study design. Data collection in this research is using test result of learning in the form of objective matter as much as 16 items, the data obtained is analyzed by using test. Based on the result of this research show that and and significant level 5%. Based on the  then hypothesis  or H1 accepted. From the result of research proved that the use of contructivism approach gives effect to science learning outcomes in class V SDN 33 Kalumbuk City of Padang academic year 2017/2018Keywords: Influence, Contructivism Approach, Learning Result of Science .
IMPLEMENTASI PEMBELAJARAN TEMATIK DI RAUDHOTUL ATHFAL AL-MUSLIMUN KOTA PALANGKA RAYA
Authors: Hidayati Sri , Muzakki Muzakki , Azmy Asmail
Published: January 2020

Kurikulum 2013 PAUD dalam proses pelaksanaannya menggunakan pembelajaran tematik. Pembelajaran tematik dipandang sesuai dengan pola kerja otak karena membahas satu tema dari berbagai konsep dan aspek perkembangan. Tujuan dari penelitian ini (1) mendiskripsikan perencanaan pembelajaran tematik di RA Al-Muslimun kota Palangka Raya. (2) mendiskripsikan pelaksanaan pembelajaran tematik di RA Al-Muslimun kota Palangka Raya. (3) mendiskripsikan penilaian pembelajaran tematik di RA Al-Muslimun kota Palangka Raya.
Structured telephone support programs in chronic heart failure may be affected by a learning curve
Authors: Tersalvi Gregorio , Vicenzi Marco , Kirsch Katharina , Gunold Hilka , Thiele Holger , Lombardi Federico , Mangner Norman , Sandri Marcus
Published: January 2020

Aims

The efficacy of a telephone support program in chronic heart failure has been questioned particularly when considering short-term follow-up. This study is aimed to assess the impact of the HeartNetCare telephone support program in chronic heart failure within 18 months of observation and to verify a possible effect of a learning-to-care curve on outcome.

Methods

We retrospectively compared a cohort of 269 chronic heart failure patients included in HeartNetCare program with 200 patients receiving usual care as a control group. All-cause death and hospitalization for heart failure or implantation of left ventricular assist device were the primary composite outcome. Secondary endpoints were the changes in left ventricular ejection fraction and in New York Heart Association (NYHA) functional class. Outcome data were also analyzed in relation to the time of enrollment from program initiation.

Results

At baseline, HeartNetCare group showed lower ejection fraction and higher NYHA class. At the follow-up, 59 HeartNetCare patients (21.9%) and 49 usual care patients (24.5%) reached the primary endpoint (P = 0.51). After 18 months of follow-up, HeartNetCare patients improved ejection fraction and NYHA class compared with the usual care patients (P < 0.001). We also observed that the HeartNetCare patients enrolled after 12 months from the initiation of the program had a more favorable outcome in primary endpoint compared with controls.

Conclusion

These results indicate that the long-term impact of a structured telephone support program might be able to positively influence symptoms and reduce events in chronic heart failure. These appreciable effects where more evident after an initial period essential for completing the learning-to-care curve.
Adherence to guidelines in the management of patients with chronic heart failure follow-up: role of periodic echocardiographic examinations
Authors: Bosso Giorgio , Valvano Antonio , Guarnaccia Franco , Fimiani Biagio , Carbone Vincenzo , Cittadini Antonio , Zito Giovanni Battista , Oliviero Ugo
Published: January 2020

Background and aim

The Adherence to Guidelines in the Treatment of patients with Chronic Heart Failure trial showed a poor adherence to the current therapeutic guidelines in 660 chronic heart failure (CHF) patients. The second phase, Adherence to Guidelines in the Treatment of patients with Chronic Heart Failure follow-up, was aimed to determine if periodic echocardiographic evaluations could improve the prognosis of CHF patients and/or increase the adherence to the guidelines.

Material and methods

Among 528 CHF patients with reduced ejection fraction from the ALERT registry, 436 patients accepted to participate in the second phase of the study between February and September 2013 and completed the 3-year follow-up phase between February and September 2016. They were randomized into two groups: Group A (n = 218) followed by clinical evaluation and ECG every 3 months, and echocardiography every 6 months and Group B (n = 218) monitored only with clinical evaluation and ECG every 3 months.

Results

The number of vascular events that occurred resulted as similar in both the groups: there were 78 hospitalizations (37 in Group A vs. 41 in Group B); 9 home-treated vascular events (4 in Group A and five in Group B); and 16 cardiovascular deaths (9 and 7, respectively). The adherence to the guidelines at the end of the trial resulted as significantly improved in both the groups in comparison with the basal evaluation, without differences between the two groups.

Conclusion

A strict follow-up of CHF patients was associated with a lower number of events and an improvement in the adherence to the guidelines. Periodic echocardiography does not modify these results.
Potential role of macrophage migration inhibitory factor in the pathogenesis of Marek’s disease
Authors: Fan Zhongjun , Wang Huanli , Pan Jiahao , Yu Shupei , Xia Wenlong
Published: January 2020

Introduction

Marek’s disease virus (MDV) can cause malignant T-cell lymphomas and immunosuppression in chickens. Macrophage migration inhibitory factor (MIF) not only plays a critical role in inhibiting T-cell responses, but also contributes to multiple aspects of tumour progression. The aim of this study was to reveal the potential role of MIF in the pathogenesis of MDV infection.

Material and Methods

MIF gene expression levels were measured by using real-time PCR. Expression was assayed at different times in chicken embryo fibroblast (CEF) cells and tissue samples of SPF chickens infected with different MDV strains and fold change was calculated by the 2–△△CT method.

Results

The expression of MIF was significantly downregulated (p < 0.05 and FC > 2) in CEF cells infected with the very virulent MDV RB1B strain at 48 h post infection (hpi) and in the skin and spleen at 14 days post infection (dpi). The reduction of MIF expression was also found in CEF cells infected by reticuloendotheliosis virus (REV), avian leukosis virus subgroup J (ALV-J), and MDV vaccine strain CVI988 or in HD11 cells stimulated with TLR2, 3, 4, and 7 ligands. Interestingly, MIF expression decreased continuously from 7 to 28 dpi in the thymus after RB1B virus infection while it increased after CVI988 virus infection. Upregulated expression of MIF was found in CEF infected with RB1B at 96 hpi and in the spleen and skin at 21 and 28 dpi.

Conclusion

The present study revealed the different expression pattern of MIF in response to MDV infection and indicated that MIF level may be associated with MDV pathogenesis.
KARAKTERISASI PENGARUH KECEPATAN LAS PADA PENGELASAN MIG AA5083H116 DENGAN ELEKTRODA ER5356
Authors: Mudjijana Mudjijana , Ilman Moch. Noer , Iswanto Priyo Tri
Published: January 2020

Abstract. Indonesia is a maritime country where 2/3 of its territory is ocean. Therefore, many ships are needed for transportation from one island to the nother within NKRI region. The AA5083H116 materials are widely used in maritime transportation vehicle due to its low density and high weldability. The research propose is to characterize the influence of welding speed of Metal Inert Gas (MIG) of AA5083H116 using ER5356 electrode on the welded joint properties. The AA5083H116 materials of 3 mm x 1200 mm x 2400 mm dimension were cut into welding specimens of 3 mm x 75 mm x 300 mm size. Any pair of specimens was welded using electrode of 0.8 mm diameter. The welding parameters being used are 19 volts of electrical voltage, 120 amperes of electrical current, and 8, 10, 12 mm/s of welding speeds. The characterization were carried out on angle distortion that measured using dial indicator on a milling machine table, X-ray radiography test, as well as physical and mechanical properties tests i.e. microstructure, Vickers micro hardness, tensile and bending strength. The research results show that the smallest distortion angle was found at welding speed of 12 mm/s, all of the welding results satisfy the distortion angle of < 5o, and the radiographic results satisfy the DEPNAKER RI regulation standard. The microstructure exhibits Al2Mg3 precipitation, Vickers hardness distributions, while the highest tensile and bending strength were obtained at welding speed of 10 mm/s.
PENGARUH DERAJAT DEFORMASI TERHADAP EVOLUSI STRUKTUR MIKRO DAN NILAI KEKERASAN LADAM DAN PAKU KUDA AKIBAT PROSES FORGING
Authors: Permana Muki Satya
Published: January 2020

This paper presents the results of advanced work as a continuation of previous observations about the identification of material and process of the horseshoe fabrication for racehorses as published in the “Jurnal Poros Vol. 15 No. 2, November 2017”. This further research is more focused on the evolution of microstructure and the value of hardness as a function of deformation degree variations of the forging process for horseshoes and horse nails. This is performed to investigate how much degree of deformation can produce form, type and phase distribution on the microstructure and the value of hardness that are relevant to the characteristics of imported products. Through this stage, the material characteristics of imported products can be approached and obtained from the local products. Thus, the quality of horseshoes and horse nails similar to imported products are expected to be able to fabricate in the local SME (Small Medium Enterprise). From the microstructure aspect, there are differences in grain shapes for Local, Australian and Swedish products because the grain forms fabricated in Sweden and Australia are more elongated than local products. This represents that the value of hardness is higher than local products except products fabricated in Australia. Local product nails have better grain because they are more equiaxial and have finer grains so that they have a high hardness value and better toughness compared to imported products. Local horseshoe show a much lower value of hardness compared to imported products. There is a peculiarity in the horseshoe because the hardness value decreases when the degree of deformation increases that is from the percentage of the work process 20% to 80%. From the microstructure of the horseshoe, the increasing deformation degree of the work process percentage 20% to 80%, the grain size is coarser and the grain size is smoother back when the percentage of the work process reaches 100%. This is proven when the percentage of the work process reaches 100%, the value of hardness increases to 147 VHN.
Fair and Flexible?! Explanations Can Improve Applicant Reactions Toward Asynchronous Video Interviews
Authors: Basch Johannes , Melchers Klaus
Published: January 2020

Asynchronous video interviews are used more and more for the preselection of potential job candidates. However, recent research has shown that they are less accepted by applicants than face-to-face interviews. Our study aimed to identify ways to improve perceptions of video interviews by using explanations that emphasize standardization and flexibility. Our results showed that an explanation stressing the higher level of standardization improved fairness perceptions, whereas an explanation stressing the flexibility concerning interview scheduling improved perceptions of usability. Additionally, the improvement of fairness perceptions eventually influenced perceived organizational attractiveness. Furthermore, older participants accepted video interviews less. Practical implications and recommendations for future research are discussed.
Data Mining Crystallization Kinetics
Authors: Brown Cameron , Maldonado Diego , Vassileiou Antony , Johnston Blair , Florence Alastair
Published: January 2020

Population balance model is a valuable modelling tool which facilitates the optimization and understanding of crystallization processes. However, in order to use this tool, it is necessary to have previous knowledge of the crystallization kinetics, specifically crystal growth and nucleation. The majority of approaches to achieve proper estimations of kinetic parameters required experimental data. Across time, a vast literature about the estimation of kinetic parameters and population balances have been published. Considering the availability of data, this work built a database with information on solute, solvent, kinetic expression, parameters, crystallization method and seeding. Correlations were assessed and clusters structures identified by hierarchical clustering analysis. The final database contains 336 data of kinetic parameters from 185 different sources. The data were analysed using kinetic parameters of the most common expressions. Subsequently, clusters were identified for each kinetic model. With these clusters, classification random forest models were made using solute descriptors, seeding, solvent, and crystallization methods as classifiers. Random forest models had an overall classification accuracy higher than 70% whereby they were useful to provide rough estimates of kinetic parameters, although these methods have some limitations.
Negligible Voltage Hysteresis with Strong Anionic Redox in Conventional Battery Electrode
Authors: Dai Kehua , Mao Jing , Zhuo Zengqing , Ai Guo , Mao Wenfeng , Feng Yan , Pan Feng , Chuang Yi-de , Liu Gao , Yang Wanli
Published: January 2020

Lattice oxygen redox reactions (ORR) offers opportunities for developing highcapacity batteries, however, suffers the notoriously high voltage hysteresis and low initial coulombic efficiency, which hinder its practical applications. Particularly, ORR was widely considered inherent to these kinetic issues. In this paper, unambiguous evidence of strong and reversible ORR is found in Na2/3Ni1/3Mn2/3O2, which displays negligible voltage hysteresis (0.1 V) and high initial coulombic efficiency with a highly stable electrochemical profile. Our independent and quantitative analysis of all the Ni, Mn and O states consistently interpret the redox mechanism of Na2/3Ni1/3Mn2/3O2, which reveals, for the first time, a conventional 3d transition-metal ORR system with facile kinetics and highly stable electrochemical profile that previously found only in cationic redox systems.
Grand-reaction method for simulations of ionization equilibria coupled to ion partitioning
Authors: Landsgesell Jonas , Rud Oleg , Hebbeker Pascal , Lunkad Raju , Košovan Peter , Holm Christian
Published: January 2020

We developed a new method for coarse-grained simulations of acid-base equilibria in a system coupled to a reservoir at a given pH and concentration of added salt, that we term the Grand-reaction method. More generally, it can be used for simulations of any reactive system coupled to a reservoir of a known composition. Conceptually, it can be regarded as an extension of the reaction ensemble, combining explicit simulations of reactions within the system and Grand-canonical exchange of particles with the reservoir. To demonstrate its strength, we applied our method to a solution of weak polyelectrolytes in equilibrium with a reservoir. Our results show that the ionization and swelling of a weak polyelectrolyte are affected by the Donnan effect due to the partitioning of ions and by the polyelectrolyte effect due to electrostatic repulsion along the chain. Both effects lead to a similar shift in ionization and swelling as a function of pH; albeit for different physical reasons. By comparison with published results, we showed that neglecting one or the other effect may lead to erroneous predictions or misinterpretations of results. In contrast, the Grand-reaction method accounts for both effects on the results and allows us to quantify them. Finally, we outline possible extensions and generalizations of the method and provide a set of guidelines for its safe application by a broad community of users.
Discovering new lipidomic features using cell type specific fluorophore expression to provide spatial and biological specificity in a multimodal workflow with MALDI IMS
Authors: Jones Marissa A. , Cho Sung Hoon , Patterson Nathan Heath , Van de Plas Raf , Spraggins Jeffrey , Boothby Mark R. , Caprioli Richard M.
Published: January 2020

Identifying the spatial distributions of biomolecules in tissue is crucial for understanding integrated function. Imaging Mass Spectrometry (IMS) allows simultaneous mapping of thousands of biosynthetic products such as lipids but has needed a means of identifying specific cell-types or functional states to correlate with molecular localization. We report here advances starting from identity marking with a genetically encoded fluorophore. The fluorescence emission data were integrated with IMS data through multimodal image processing with advanced registration techniques and data-driven image fusion. In an unbiased analysis of spleens, this integrated technology enabled identification of ether lipid species preferentially enriched in germinal centers. We propose that this use of genetic marking for microanatomical regions of interest can be paired with molecular information from IMS for any tissue, cell-type, or activity state for which fluorescence is driven by a gene-tracking allele and ultimately with outputs of other means of spatial mapping.
PEMODELAN TARIKAN PERJALANAN ANGKUTAN BARANG DI PROVINSI KALIMANTAN TIMUR
Authors: Arifin Triana Sharly P.
Published: January 2020

Abstract East Kalimantan is a province with a large area in Indonesia. This causes the transportation of goods in the province is also large. The pattern of movement of goods in East Kalimantan Province is influenced by the potential of its natural resources. This study aims to analyze the attraction model of the movement of freight transportation in East Kalimantan Province, using the Origin and Destination Matrix of movement for 9 districts/cities in East Kalimantan Province, as well as the movement of 3 external zones. Furthermore the Origin and Destination Matrix of the movement is converted to trip units/year based on the type of truck most often used to transport goods. This is done so that in the analysis process, variables can be correlated with socio-economic data as independent variables. The analysis was performed using a zone-based correlation model, a step-by-step method of type 1. The results show that the best model for the attraction of freight transportation in East Kalimantan Province is a model that uses independent variables of egg production and chicken livestock, with a coefficient of determination of 0.564. Keywords: trip attraction,freight  transportation, Origin and Destination Matrix, external zone  Abstrak Kalimantan Timur merupakan suatu provinsi dengan luas wilayah yang besar di Indonesia. Hal ini menyebabkan angkutan barang di provinsi ini besar pula. Pola pergerakan barang di Provinsi Kalimantan Timur dipengaruhi oleh potensi sumber daya alam yang dimilikinya. Studi ini bertujuan untuk menganalisis model tarikan pergerakan angkutan barang di Provinsi Kalimantan Timur, dengan menggunakan Matriks Asal Tujuan pergerakan untuk  9 kabupaten/kota di Provinsi Kalimantan Timur, serta pergerakan 3 zona eksternal. Selanjutnya Matriks Asal Tujuan pergerakan dikonversikan ke satuan trip/tahun berdasarkan jenis truk yang paling sering digunakan untuk mengangkut barang. Hal ini dilakukan agar dalam proses analisis, variabel dapat dikorelasikan dengan data sosial-ekonomi sebagai variabel bebas. Analisis dilakukan dengan menggunakan model korelasi berbasis zona, metode langkah demi langkah tipe 1. Dari hasil pemodelan diperoleh bahwa model terbaik untuk tarikan angkutan barang di Provinsi Kalimantan Timur adalah model yang menggunakan variabel-variabel bebas pro-duksi telur dan ternak ayam, dengan koefisien determinasi sebesar 0,564. Kata-kata kunci: tarikan pergerakan, angkutan barang, Matriks Asal dan Tujuan, zona eksternal
KAJIAN SPASIAL LOKASI BERBELANJA DI KOTA BANDUNG
Authors: Joewono Tri Basuki , Andrianto Marco
Published: January 2020

Abstract Shoppers consider many aspects in choosing specific location from variety of shopping location. Spatial analysis is used to determine the catchment area of shopping location based on the location of shoppers’ residence along with the correlation with shoppers’ activity and characteristic. The purposes of this study are to analyze the catchment area of shopping location in Bandung based on shopper’s preferences and to analyze the shopping travel pattern. The questionnaire data about the grocery shopping trip is analyzed using Thiessen Polygon and Buffering Method. The analysis shows that there is a mismatch between the market service coverage and the preferences of respondent destination. Analysis shows that shoppers will choose the shopping location by considering the distance of shopping location from home, travel costs, and travel duration in selecting any type of shopping location. Keywords: shopping location, spatial analysis, GIS, catchment area, shopping trip characteristics  Abstrak Ada banyak hal yang dipertimbangkan oleh pelaku belanja dalam memilih lokasi berbelanja yang beragam. Analisis spasial dipergunakan untuk menjelaskan daerah cakupan lokasi belanja berdasarkan lokasi tempat tinggal serta keterkaitannya dengan aktivitas dan karakteristik pelaku belanja. Tujuan penelitian ini adalah menganalisis daerah cakupan lokasi berbelanja pilihan pelaku belanja di Kota Bandung dan menganalisis pola perjalanan berbelanja. Data hasil penyebaran kuisioner mengenai perjalanan berbelanja kebutuhan sehari-hari dianalisis menggunakan Metode Thiessen Polygon dan Metode Buffer. Hasil analisis menunjukkan bahwa terdapat ketidaksesuaian antara luas cakupan layanan suatu lokasi belanja dengan luas jangkauan layanan lokasi pilihan pelaku belanja. Analisis menunjukkan bahwa pelaku belanja memilih lokasi belanja dengan mempertimbangkan jarak dari tempat tinggal, durasi, dan biaya perjalanan. Kata-kata kunci: lokasi berbelanja, analisis spasial, GIS, daerah cakupan, karakteristik perjalanan berbelanja
Variabilidade e Tendências das Precipitações Pluviais em Rio do Sul – SC
Authors: Murara Pedro , Mendonça Magaly
Published: January 2020

As inundações urbanas compreendem uma das principais problemáticas socionaturais. Conhecer a vulnerabilidade da população atingida pelas inundações é fundamental para a compreensão de ações que visem a mitigar a ocorrência desse fenômeno. Um dos primeiros passos da investigação da vulnerabilidade a inundações é conhecer a dinâmica pluvial da localidade. Nesse contexto, o presente artigo objetivou caracterizar a variabilidade das precipitações pluviais e sua relação com a ocorrência de inundações no município de Rio do Sul, localizado na mesorregião do Vale do Itajaí, no Estado de Santa Catarina. A metodologia envolveu uma intensa análise de dados de precipitações pluviais e registros de inundações, por meio de técnicas estatísticas e aplicação dos índices ClimPACT. Os resultados identificaram a estação de verão como a mais chuvosa e o outono como o período de diminuição nos totais de chuva, no entanto, as chuvas mais intensas ocorrem na estação de inverno, período em que há os maiores registros de inundações. Por fim, evidenciou-se que a região apresentou aumento nos registros dos totais pluviais e tendência à ocorrência de eventos extremos de chuvas.  Variability and Trends of Rainfall Precipitation in Rio do Sul - SC A B S T R A C TUrban floods comprise one of the main socialnatural problems. Knowing the vulnerability of the population affected by floods is fundamental for understanding actions that aim to mitigate the occurrence of this phenomenon. One of the first steps in the investigation of vulnerability to floods is to know the pluvial dynamics of the locality. In this context, the present article aimed to characterize the rainfall variability and its relation with the occurrence of floods in the municipality of Rio do Sul, located in the mesoregion of the Itajaí Valley, in the State of Santa Catarina. The methodology involved an intense analysis of rainfall data and flood records, using statistical techniques and application of the ClimPACT indices. The results identified the summer season as the rainy season and autumn as the period of decline in rainfall totals, however, the most intense rains occur in the winter season, when there are the highest flood records. Finally, it was evidenced that the region presented an increase in rainfall total records and tendency to extreme rainfall events.Keywords: Rainfall, Historic Serie, Software R, ClimPACT.
Adaptações estruturais e potencial plástico de Schinus terebinthifolia Raddi. (Anacardiaceae) em diferentes formações de restinga
Authors: Melo Júnior João Carlos Ferreira , Gonçalves Taise Milena , Schöne Raissa Iana Leite Jardim
Published: January 2020

Plantas da Restinga se desenvolvem sob condições ambientais heterogêneas, principalmente quando se distribuem ao longo de um gradiente. O presente estudo avaliou as adaptações morfoanatômicas foliares de Schinus terebinthifolia Raddi (Anacardiaceae) ocorrente em perfis fitofisionômicos de restinga: arbustiva, arbustivo-arbórea e floresta de transição. Em cada perfil fitofisionômico foram selecionados dez indivíduos dos quais foram coletadas quinze folhas totalmente expandidas para análise de atributos morfoanatômicos funcionais, tais como: massa fresca e seca, área foliar, área específica foliar, densidade foliar e estomática e espessura de tecidos. Variáveis ambientais como nutrição edáfica e radiação luminosa foram mensuradas. As populações foram comparadas por meio de ANOVA e PCA. Os atributos anatômicos mostraram-se menos plásticos que os morfológicos. As populações mostraram-se distintas entre si, sendo tipicamente xeromórfica na formação arbustiva e mesomórfica na fisionomia florestal, em função da oferta nutricional do solo, além da variância de temperatura e umidade. As diferenças encontradas são uma resposta aos fatores ambientais, principalmente ao gradiente edáfico que atua como um filtro ambiental que direcionada as adaptações estruturais da espécie.  Structural adaptations and plastic potential of Schinus terebinthifolia Raddi. (Anacardiaceae) in different Restinga formations A B S T R A C TRestinga plants develop under heterogeneous environmental conditions, mainly when are distributed along a gradient. The present study evaluated the foliar morphoanatomy adaptations in Schinus terebinthifolia Raddi. (Anacardiaceae) occurring in three different formations of Restinga: shrubby restinga, shrubby and wooded restinga and transition forest. In each formation were selected ten individuals were selected from which 15 fully expanded leaves were collected for analysis of function morphoanatomic attributes. Environmental variables as edaphic nutrition and light radiation were measured. Populations had been compared by analysis of variance (ANOVA) and PCA. The anatomic attributes were less plastic than the morphologic. The populations were distinct from each other, being typically xeromorphic in the shrubby formation and mesomorphic in transition forest, as a function of a better or worse supply of soil nutrition. The differences found are an answer to the environmental factors, mainly the edaphic gradient which acts as an environmental filter that directs the structural adaptations of the species.Keywords: conservation of biodiversity, leaf morphoanatomy, edaphic gradient, phenotypic plasticity, oligotrophic scleromorphism.
Impact Optimization of Battery Energy Storage System in Microgrid Operation
Authors: Adjei Bernard , Donkoh Elvis K. , Otoo Dominic , Owusu-Ansah Emmanuel De-Graft Johnson , Mahama Francois
Published: January 2020

In microgrid operation, one of the most vital tasks of the system control is to wiselydecide between selling excess power to the local grid or charge the Battery Energy Storage System (BESS). Our study uses Mixed-Integer Linear Programming to investigate the impact of storage system on the operational cost of a microgrid. The results suggested that the presence of BESS would relieve the pressure on the utility grid but not the cost of electricity due to the expensiveÂ nature of the storage plant. In view of this, it will be more beneficial to sell excess renewable generated power to the utility grid than to invest in a storage system for larger microgrids.
Simple Properties and Existence Theorem for the Henstock-Kurzweil-Stieltjes Integral of Functions Taking Values on C[a,b] Space-valued Functions
Authors: Cunanan Andrew Felix IV Suarez , Benitez Julius
Published: January 2020

Henstock--Kurzweil integral, a nonabsolute integral, is a natural extension of the Riemann integral that was studied independently by Ralph Henstock and Jaroslav Kurzweil. This paper will introduce the Henstock--Kurzweil--Stieltjes integral of $\mathcal{C}[a,b]$-valued functions defined on a closed interval $[f,g]\subseteq\mathcal{C}[a,b]$, where $\mathcal{C}[a,b]$ is the space of all continuous real-valued functions defined on $[a,b]\subseteq\mathbb{R}$. Some simple properties of this integral will be formulated including the Cauchy criterion and an existence theorem will be provided.