bluuebunny/crossref_metadata_2025 huggingface dataset:
From Gas Phase Observations to Solid State Reality: The Identification and Isolation of Trinuclear Salicylaldoximato Copper Complexes
Authors: Roach Benjamin D. , Forgan Ross S. , Kamenetzky Eduardo , Parsons Simon , Plieger Paul G. , White Fraser J. , Woodhouse Sidney , Tasker Peter A.
Published: September 2022

Conditions have been identified in which phenolic aldoximes and ketoximes of the types used in commercial solvent extraction processes can be doubly deprotonated and generate polynuclear Cu complexes with lower extractant:Cu molar ratios than those found in commercial operations. Electrospray mass spectrometry has provided an insight into the solution speciation in extraction experiments and has identified conditions to allow isolation and characterization of polynuclear Cu-complexes. Elevation of pH is effective in enhancing the formation of trinuclear complexes containing planar {Cu3-μ3-O}4+ or {Cu3-μ3-OH}5+ units. DFT calculations suggest that such trinuclear complexes are more stable than other polynuclear species. Solid structures of complexes formed by a salicylaldoxime with a piperidino substituent ortho to the phenolic OH group (L9H2) contain two trinuclear units in a supramolecular assembly, {[Cu3OH(L9H)3(ClO4)](ClO4)} 2, formed by H-bonding between the central {Cu3-μ3-OH}5+ units and oxygen atoms in the ligands of an adjacent complex. Whilst the lower ligand:Cu molar ratios provide more efficient Cu-loading in solvent extraction processes, the requirement to raise the pH of the aqueous phase to achieve this will make it impractical in most commercial operations because extraction will be accompanied by the precipitation (as oxyhydroxides) of Fe(III) which is present in significant quantities in feed solutions generated by acid leaching of most Cu ores.
Preparation of Biocomposites with Natural Reinforcements: The Effect of Native Starch and Sugarcane Bagasse Fibers
Authors: Józó Muriel , Várdai Róbert , Bartos András , Móczó János , Pukánszky Béla
Published: September 2022

Biocomposites were prepared from poly(lactic acid) and two natural reinforcements, a native starch and sugarcane bagasse fibers. The strength of interfacial adhesion was estimated by model calculations, and local deformation processes were followed by acoustic emission testing. The results showed that the two additives influence properties differently. The strength of interfacial adhesion and thus the extent of reinforcement are similar because of similarities in chemical structure, the large number of OH groups in both reinforcements. Relatively strong interfacial adhesion develops between the components, which renders coupling inefficient. Dissimilar particle characteristics influence local deformation processes considerably. The smaller particle size of starch results in larger debonding stress and thus larger composite strength. The fracture of the bagasse fibers leads to larger energy consumption and to increased impact resistance. Although the environmental benefit of the prepared biocomposites is similar, the overall performance of the bagasse fiber reinforced PLA composites is better than that offered by the PLA/starch composites.
Meta-Optics-Empowered Switchable Integrated Mode Converter Based on the Adjoint Method
Authors: Ha Yingli , Guo Yinghui , Pu Mingbo , Xu Mingfeng , Li Xiong , Ma Xiaoliang , Zou Fang , Luo Xiangang
Published: September 2022

Monolithic integrated mode converters with high integration are essential to photonic integrated circuits (PICs), and they are widely used in next-generation optical communications and complex quantum systems. It is expected that PICs will become more miniaturized, multifunctional, and intelligent with the development of micro/nano-technology. The increase in design space makes it difficult to realize high-performance device design based on traditional parameter sweeping or heuristic design, especially in the optimal design of reconfigurable PIC devices. Combining the mode coupling theory and adjoint calculation method, we proposed a design method for a switchable mode converter. The device could realize the transmission of TE0 mode and the conversion from TE0 to TE1 mode with a footprint of 0.9 × 7.5 μm2 based on the phase change materials (PCMs). We also found that the mode purity could reach 78.2% in both states at the working wavelength of 1.55 μm. The designed method will provide a new impetus for programmable photonic integrated devices and find broad application prospects in communication, optical neural networks, and sensing.
A Nanoscale Sensor Based on a Toroidal Cavity with a Built-In Elliptical Ring Structure for Temperature Sensing Application
Authors: Liu Feng , Yan Shubin , Shen Lifang , Liu Pengwei , Chen Lili , Zhang Xiaoyu , Liu Guang , Liu Jilai , Li Tingsong , Ren Yifeng
Published: September 2022

In this article, a refractive index sensor based on Fano resonance, which is generated by the coupling of a metal–insulator–metal (MIM) waveguide structure and a toroidal cavity with a built-in elliptical ring (TCER) structure, is presented. The finite element method (FEM) was employed to analyze the propagation characteristics of the integral structure. The effects of refractive index and different geometric parameters of the structure on the sensing characteristics were evaluated. The maximum sensitivity was 2220 nm/RIU with a figure of merit (FOM) of 58.7, which is the best performance level that the designed structure could achieve. Moreover, due to its high sensitivity and simple structure, the refractive index sensor can be applied in the field of temperature detection, and its sensitivity is calculated to be 1.187 nm/℃.
Possible Synergies of Nanomaterial-Assisted Tissue Regeneration in Plasma Medicine: Mechanisms and Safety Concerns
Authors: Shaw Priyanka , Vanraes Patrick , Kumar Naresh , Bogaerts Annemie
Published: September 2022

Cold atmospheric plasma and nanomedicine originally emerged as individual domains, but are increasingly applied in combination with each other. Most research is performed in the context of cancer treatment, with only little focus yet on the possible synergies. Many questions remain on the potential of this promising hybrid technology, particularly regarding regenerative medicine and tissue engineering. In this perspective article, we therefore start from the fundamental mechanisms in the individual technologies, in order to envision possible synergies for wound healing and tissue recovery, as well as research strategies to discover and optimize them. Among these strategies, we demonstrate how cold plasmas and nanomaterials can enhance each other’s strengths and overcome each other’s limitations. The parallels with cancer research, biotechnology and plasma surface modification further serve as inspiration for the envisioned synergies in tissue regeneration. The discovery and optimization of synergies may also be realized based on a profound understanding of the underlying redox- and field-related biological processes. Finally, we emphasize the toxicity concerns in plasma and nanomedicine, which may be partly remediated by their combination, but also partly amplified. A widespread use of standardized protocols and materials is therefore strongly recommended, to ensure both a fast and safe clinical implementation.
Thermal Transport Properties of Diamond Phonons by Electric Field
Authors: Zhao Yongsheng , Yan Fengyun , Liu Xue , Ma Hongfeng , Zhang Zhenyu , Jiao Aisheng
Published: September 2022

For the preparation of diamond heat sinks with ultra-high thermal conductivity by Chemical Vapor Deposition (CVD) technology, the influence of diamond growth direction and electric field on thermal conductivity is worth exploring. In this work, the phonon and thermal transport properties of diamond in three crystal orientation groups (<100>, <110>, and <111>) were investigated using first-principles calculations by electric field. The results show that the response of the diamond in the three-crystal orientation groups presented an obvious anisotropy under positive and negative electric fields. The electric field can break the symmetry of the diamond lattice, causing the electron density around the C atoms to be segregated with the direction of the electric field. Then the phonon spectrum and the thermodynamic properties of diamond were changed. At the same time, due to the coupling relationship between electrons and phonons, the electric field can affect the phonon group velocity, phonon mean free path, phonon–phonon interaction strength and phonon lifetime of the diamond. In the crystal orientation [111], when the electric field strength is ±0.004 a.u., the thermal conductivity is 2654 and 1283 W·m−1K−1, respectively. The main reason for the change in the thermal conductivity of the diamond lattice caused by the electric field is that the electric field has an acceleration effect on the extranuclear electrons of the C atoms in the diamond. Due to the coupling relationship between the electrons and the phonons, the thermodynamic and phonon properties of the diamond change.
A Review on the Different Aspects and Challenges of the Dry Reforming of Methane (DRM) Reaction
Authors: Hussien Aseel G. S. , Polychronopoulou Kyriaki
Published: September 2022

The dry reforming of methane (DRM) reaction is among the most popular catalytic reactions for the production of syngas (H2/CO) with a H2:CO ratio favorable for the Fischer–Tropsch reaction; this makes the DRM reaction important from an industrial perspective, as unlimited possibilities for production of valuable products are presented by the FT process. At the same time, simultaneously tackling two major contributors to the greenhouse effect (CH4 and CO2) is an additional contribution of the DRM reaction. The main players in the DRM arena—Ni-supported catalysts—suffer from both coking and sintering, while the activation of the two reactants (CO2 and CH4) through different approaches merits further exploration, opening new pathways for innovation. In this review, different families of materials are explored and discussed, ranging from metal-supported catalysts, to layered materials, to organic frameworks. DRM catalyst design criteria—such as support basicity and surface area, bimetallic active sites and promoters, and metal–support interaction—are all discussed. To evaluate the reactivity of the surface and understand the energetics of the process, density-functional theory calculations are used as a unique tool.
Functional Silane-Based Nanohybrid Materials for the Development of Hydrophobic and Water-Based Stain Resistant Cotton Fabrics Coatings
Authors: Sfameni Silvia , Lawnick Tim , Rando Giulia , Visco Annamaria , Textor Torsten , Plutino Maria Rosaria
Published: September 2022

The textile-finishing industry, is one of the main sources of persistent organic pollutants in water; in this regard, it is necessary to develop and employ new sustainable approaches for fabric finishing and treatment. This research study shows the development of an efficient and eco-friendly procedure to form highly hydrophobic surfaces on cotton fabrics using different modified silica sols. In particular, the formation of highly hydrophobic surfaces on cotton fabrics was studied by using a two-step treatment procedure, i.e., first applying a hybrid silica sol obtained by hydrolysis and subsequent condensation of (3-Glycidyloxypropyl)trimethoxy silane with different alkyl(trialkoxy)silane under acid conditions, and then applying hydrolyzed hexadecyltrimethoxysilane on the treated fabrics to further improve the fabrics’ hydrophobicity. The treated cotton fabrics showed excellent water repellency with a water contact angle above 150° under optimum treatment conditions. The cooperative action of rough surface structure due to the silica sol nanoparticles and the low surface energy caused by long-chain alkyl(trialkoxy)silane in the nanocomposite coating, combined with the expected roughness on microscale due to the fabrics and fiber structure, provided the treated cotton fabrics with excellent, almost super, hydrophobicity and water-based stain resistance in an eco-sustainable way.
Template-Free Hydrothermal Synthesis of Octahedron-, Diamond-, and Plate-like ZrO2 Mono-Dispersions
Authors: Gao Ling , Zhi Hao , Zhang Shengnan , Liu Shifeng
Published: September 2022

Anisotropic ZrO2 particles with octahedron-, diamond- and plate-like morphologies are successfully synthesized by a facile hydrothermal treatment approach using NaBF4 as mineralizer. The concentration of mineralizers play a crucial role on the formation of shape-controlled ZrO2 particles thus affect the particle size. With the increasing concentration of mineralizer, the crystalline sizes of the primary single-crystal and the secondary particle size both increase. With the introduction of NaBF4, F− plays an essential role in tuning the crystallinity and size of primary ZrO2 nanorods along [001] direction. The synergistic effect of F− and B3+ result in different epitaxial growth rate. And the secondary particles mainly crystallize on the small primary nanoparticles through the oriented attachment mechanism. The as-prepared ZrO2 particles with different sizes and shapes exhibit different photocatalytic efficiency for the degradation of organic dyes. Under UV irradiation, the highest MB degradation rate of 88% was observed within 60 min for ZrO2 photocatalyst synthesized with 0.01 mol/L NaBF4 mineralizer.
Microstructure and Mechanical Properties of Unidirectional, Laminated Cf/SiC Composites with α-Al2O3 Nanoparticles as Filler
Authors: Yang Lixia , Wang Fei , Liao Jiahao , Chen Zhaofeng , Kou Zongde
Published: September 2022

The effects of an α-Al2O3 nanoparticle filler in the SiC matrix on the mechanical properties and failure mechanism of the unidirectional, laminated carbon fiber-reinforced SiC composites were investigated in this work. First, α-Al2O3 nanoparticles were added to the carbon fiber bundles using a slurry impregnation method, and then the Cf/SiC composite with an α-Al2O3 nanoparticle filler (Cf/SiC-Al2O3) was fabricated using a precursor infiltration and pyrolysis method. The microstructure of the Cf/SiC-Al2O3 composite showed chemical compatibility between the α-Al2O3 and the pyrolysis SiC. The Cf/SiC-Al2O3 composite with a low porosity of ~6.67% achieved a good flexural strength of 629.3 MPa and a good fracture toughness of 25.2 MPa·m1/2. The interlaminar shear strength of the Cf/SiC-Al2O3 composite was 11.7 MPa. The SiC-Al2O3 matrix also presented a considerable Young’s modulus of 138.2 ± 8.66 GPa and hardness of 10.3 ± 1.03 GPa. Further analysis indicated that the good mechanical properties with the addition of an α-Al2O3 filler were not only related to the dense matrix and the improvement of the mechanical properties of the matrix. They also originated from the thermal residual compressive stress in the SiC matrix close to the α-Al2O3 nanoparticles caused by the thermal expansion mismatch, which could reflect and close the cracks in the matrix. The findings of this study provide more methods for designing new composites exhibiting a good performance.
The Role of STING in Liver Injury Is Both Stimulus- and Time-Dependent
Authors: Siao Kevin , Le Guillou Dounia , Maher Jacquelyn J. , Duwaerts Caroline C.
Published: September 2022

STING, Tmem173, is involved in liver injury caused by both infectious and sterile inflammatory models. Its role in toxic liver injury and non-alcoholic fatty liver disease (NAFLD), however, is less clear. While a few groups have investigated its role in NAFLD pathogenesis, results have been conflicting. The objective of this study was to clarify the exact role of STING in toxic liver injury and NAFLD models. Goldenticket mice (Tmem173gt), which lack STING protein, were subjected to either a toxic liver injury with tunicamycin (TM) or one of two dietary models of non-alcoholic fatty liver disease: high fructose feeding or Fructose-Palmitate-Cholesterol (FPC) feeding. Three days after TM injection, Tmem173gt mice demonstrated less liver injury (average ALT of 54 ± 5 IU/L) than control mice (average ALT 108 ± 24 IU/L). In contrast, no significant differences in liver injury were seen between WT and Tmem173gt mice fed either high fructose or FPC. Tmem173gt mice only distinguished themselves from WT mice in their increased insulin resistance. In conclusion, while STING appears to play a role in toxic liver injury mediated by TM, it plays little to no role in two dietary models of NAFLD. The exact role of STING appears to be stimulus-dependent.
Implementation of Universal School Meals during COVID-19 and beyond: Challenges and Benefits for School Meals Programs in Maine
Authors: Cohen Juliana F. W. , Polacsek Michele , Hecht Christina E. , Hecht Ken , Read Margaret , Olarte Deborah A. , Patel Anisha I. , Schwartz Marlene B. , Turner Lindsey , Zuercher Monica , Gosliner Wendi , Ritchie Lorrene D.
Published: September 2022

School meals play a major role in supporting children’s diets and food security, and policies for universal school meals (USM) have the potential to contribute to positive child health outcomes. During the COVID-19 pandemic, schools provided free school meals to all students in the United States, but this national USM policy ended in school year (SY) 2022–2023; however, a few states have adopted policies to continue USM statewide for SY 2022–2023. Research examining the challenges and strategies for successful continuation of USM is essential, along with studying pandemic-related challenges that are likely to persist in schools. Therefore, we conducted a study in Maine (with a USM policy) to evaluate the impact of COVID-19 and the concurrent implementation of USM, as well as examine differences in implementation by school characteristics, throughout the state. A total of n = 43 school food authorities (SFAs) throughout Maine completed surveys. SFAs reported multiple benefits of USM including increased school meal participation; reductions in the perceived stigma for students from lower-income households and their families; and no longer experiencing unpaid meal charges and debt. SFAs also experienced challenges due to the COVID-19 pandemic, particularly regarding costs. When considering future challenges, most respondents were concerned with obtaining income information from families, product and ingredient availability, and the costs/financial sustainability of the school meal programs. Overall, USM may have multiple important benefits for students and schools, and other states should consider implementation of a USM policy.
The Performances of SNAQ, GLIM, mNICE, and ASPEN for Identification of Neurocritically Ill Patients at High Risk of Developing Refeeding Syndrome
Authors: Liu Na , Zhao Xiao-Lin , Xiong Rui-Qi , Chen Quan-Feng , Wu Yong-Ming , Lin Zhen-Zhou , Wang Sheng-Nan , Wu Tong , Pan Su-Yue , Huang Kai-Bin
Published: September 2022

We previously found that neurocritically ill patients are prone to refeeding syndrome (RFS), a potentially life-threatening complication. However, there is no unified or validated consensus on the screening tool for RFS so far. We aimed to validate and compare the performance of four screening tools for RFS in neurocritically ill patients. We conducted a single-center, observational, retrospective cohort study among neurocritically ill adult patients who were admitted to the neurocritical care unit (NCU), and who received enteral nutrition for 72 h or longer. They were scored on the Short Nutritional Assessment Questionnaire (SNAQ), the Global Leadership Initiative on Malnutrition (GLIM), the modified criteria of the Britain’s National Institute for Health and Care Excellence (mNICE), and ASPEN Consensus Recommendations for Refeeding Syndrome (ASPEN) scales to predict RFS risk via admission data. The performance of each scale in predicting RFS was evaluated. Logistic regression analysis was used to identify the independent risk factors for RFS, and they were added to the above scales to strengthen the identification of RFS. Of the 478 patients included, 84 (17.57%) developed RFS. The sensitivity of the SNAQ and GLIM was only 20.2% (12.6–30.7%), although they had excellent specificities of 84.8% (80.8–88.1%) and 86.0% (82.1–89.2%), respectively; mNICE predicted RFS with a sensitivity of 48.8% (37.8–59.9%) and a specificity of 65.0% (60.0–69.9%); ASPEN had the highest Youden index, with a sensitivity and specificity of 53.6% (42.4–64.4%) and 64.7% (59.8–69.4%), respectively. The Area Under the receiver operating characteristic Curves (AUC) of SNAQ, GLIM, mNICE, and ASPEN to predict RFS were 0.516 (0.470–0.561), 0.533 (0.487–0.579), 0.568 (0.522–0.613), and 0.597 (0.551–0.641), respectively. We identified age, Acute Physiology and Chronic Health Evaluation II (APACHE II), Sequential Organ Failure Assessment (SOFA), and Glasgow Coma Scale (GCS) score as independent risk factors of RFS, and the combination of GCS and age can improve the AUC of ASPEN to 0.664 (0.620–0.706) for predicting RFS. SNAQ, GLIM, mNICE, and ASPEN do not perform well in identifying neurocritically ill patients at high risk of RFS, although ASPEN appears to have relatively a good validity among them. Combining GCS and age with ASPEN slightly improves RFS recognition, but it still leaves a lot of room for improvement.
Management Strategies and Nursing Activities for Nutritional Care in Hospitalized Patients with Cognitive Decline: A Scoping Review
Authors: Liquori Gloria , De Leo Aurora , De Nuzzo Daniele , D’Inzeo Victoria , Arancio Rosario Marco , Di Simone Emanuele , Dionisi Sara , Giannetta Noemi , Ricciardi Francesco , Fabbian Fabio , Orsi Giovanni Battista , Di Muzio Marco , Napoli Christian
Published: September 2022

Cognitive impairment and dementia can negatively impact the nutritional capacities of older people. Malnutrition is common in hospitalized frail elderly people with cognitive impairment and negatively affects prognosis. Malnutrition worsens the quality of life and increases morbidity and mortality. This scoping review aimed to identify factors affecting the risk of malnutrition and preventive strategies in hospitalized patients with cognitive impairment, focusing on nursing interventions. The authors researched population, context, and concept in international databases of nursing interest. Full texts that met the inclusion criteria were selected and reviewed. The extracted data were subject to thematic analysis. A five-stage approach, already reported in the scientific literature, was utilized in the following scoping review. Of 638 articles yielded, 9 were included. Two focus areas were identified as follows: (1) prevalence and risk factors of malnutrition in older patients with cognitive decline; (2) nursing strategies used to enhance clinical outcomes. Nursing health interventions aim to recognize and reduce malnutrition risk, positively impacting this phenomenon. A multidisciplinary team is essential to meet the nutritional needs of these patients.
β-Cyclodextrin-Aided Aqueous Extraction of Antioxidant Polyphenols from Peppermint (Mentha × piperita L.)
Authors: Athanasiadis Vassilis , Palaiogiannis Dimitrios , Bozinou Eleni , Lalas Stavros I. , Makris Dimitris P.
Published: September 2022

This study explored the use of β-cyclodextrin (β-CD) as an additive to improve the aqueous extraction of antioxidant polyphenols from peppermint (Mentha × piperita). For this purpose, an initial single-factor screening was performed to test the effect of β-CD concentration on the yield of polyphenol extraction. In the following step, the extraction process was optimized through response surface methodology, considering β-CD and temperature as the process variables. The experimental design included the yield in total polyphenols and total flavonoids, the ferric-reducing power and the antiradical activity as the responses. The optimization showed that each response was maximized at different levels of β-CD concentration, but in all cases, 80 °C was the optimum extraction temperature. The composition of the extracts produced was profiled by high-performance liquid chromatography (HPLC). A comparison of the β-CD extract with the aqueous and hydroethanolic extracts revealed that the addition of β-CD at a specified concentration might boost aqueous polyphenol extraction. On the other hand, the hydroethanolic extract exhibited the richest polyphenolic profile. It was also shown that the β-CD extracts might possess improved antiradical activity. It was concluded that β-CD-aided polyphenol extraction from M. piperita may provide extracts with enriched polyphenolic composition and improved antioxidant characteristics, and this technique may be considered an alternative to solvent extraction.
SIGLEC-1 in Systemic Sclerosis: A Useful Biomarker for Differential Diagnosis
Authors: Höppner Jakob , Casteleyn Vincent , Biesen Robert , Rose Thomas , Windisch Wolfram , Burmester Gerd Rüdiger , Siegert Elise
Published: September 2022

Systemic Sclerosis (SSc) is a clinically heterogeneous disease that includes an upregulation of type I interferons (IFNs). The aim of this observational study was to investigate the IFN-regulated protein Sialic Acid–Binding Ig-like Lectin 1 (SIGLEC-1) as a biomarker for disease phenotype, therapeutic response, and differential diagnosis in SSc. Levels of SIGLEC-1 expression on monocytes of 203 SSc patients were determined in a cross-sectional and longitudinal analysis using multicolor flow cytometry, then compared to 119 patients with other rheumatic diseases and 13 healthy controls. SSc patients higher SIGLEC-1 expression on monocytes (2097.94 ± 2134.39) than HCs (1167.45 ± 380.93; p = 0.49), but significantly lower levels than SLE (8761.66 ± 8325.74; p < 0.001) and MCTD (6414.50 ± 1846.55; p < 0.001) patients. A positive SIGELC-1 signature was associated with reduced forced expiratory volume (p = 0.007); however, we were unable to find an association with fibrotic or vascular disease manifestations. SIGLEC-1 remained stable over time and was independent of changes in immunosuppressive therapy. However, SIGLEC-1 is suitable for differentiating SSc from other connective tissue diseases. SIGLEC-1 expression on monocytes can be useful in the differential diagnosis of connective tissue disease but not as a biomarker for SSc disease manifestations or activity.
Fluorinated Protein and Peptide Materials for Biomedical Applications
Authors: Monkovic Julia M. , Gibson Halle , Sun Jonathan W. , Montclare Jin Kim
Published: September 2022

Fluorination represents one of the most powerful modern design strategies to impart biomacromolecules with unique functionality, empowering them for widespread application in the biomedical realm. However, the properties of fluorinated protein materials remain unpredictable due to the heavy context-dependency of the surrounding atoms influenced by fluorine’s strong electron-withdrawing tendencies. This review aims to discern patterns and elucidate design principles governing the biochemical synthesis and rational installation of fluorine into protein and peptide sequences for diverse biomedical applications. Several case studies are presented to deconvolute the overgeneralized fluorous stabilization effect and critically examine the duplicitous nature of the resultant enhanced chemical and thermostability as it applies to use as biomimetic therapeutics, drug delivery vehicles, and bioimaging modalities.
Development and Validation of a HPLC–MS/MS Method to Measure Nifuroxazide and Its Application in Healthy and Glioblastoma-Bearing Mice
Authors: Ceruti Tommaso , D’Alessandris Quintino Giorgio , Frapolli Roberta , Gopalakrishnan Jay , Buccarelli Mariachiara , Meroni Marina , Lauretti Liverana , Ricci-Vitiani Lucia , Pallini Roberto , Zucchetti Massimo
Published: September 2022

Nifuroxazide (NAZ), a nitrofuran derivative used to treat diarrhea, has been recently shown to possess anticancer activity. However, its pharmacokinetic profile is poorly known. The pharmacokinetic profile of NAZ was thus investigated in mice using a newly developed method based on high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS). We determined the concentrations of NAZ in the plasma and brain tissue of mice treated with the drug. The method proved to be specific, reproducible, precise, and accurate. It also demonstrated high sensitivity, reaching an LOQ in the order of ppb for both matrices, using samples of 100 µL or 0.2 g. The new HPLC–MS/MS assay was successfully applied to study the pharmacokinetics of NAZ after chronic intraperitoneal administration in mice at a dose of 30 mg/kg. One hour after treatment, plasma concentrations of NAZ were in the range of 336–2640 ng/mL. Moreover, unlike the brains of healthy mice or those with healed mechanical injuries, we found that NAZ was able to cross the injured blood–brain barrier of tumor-infiltrated brains. Thus, following i.p. administration, NAZ reaches systemic levels suitable for testing its efficacy in preclinical models of glioblastoma. Overall, these pharmacokinetic data provide robust evidence supporting the repositioning of NAZ as an antitumor drug.
Clinical and Electrophysiological Changes in Pediatric Spinal Muscular Atrophy after 2 Years of Nusinersen Treatment
Authors: Axente Mihaela , Mirea Andrada , Sporea Corina , Pădure Liliana , Drăgoi Cristina Manuela , Nicolae Alina Crenguța , Ion Daniela Adriana
Published: September 2022

In the new therapeutic era, disease-modifying treatment (nusinersen) has changed the natural evolution of spinal muscular atrophy (SMA), creating new phenotypes. The main purpose of the retrospective observational study was to explore changes in clinical evolution and electrophysiological data after 2 years of nusinersen treatment. We assessed distal compound motor action potential (CMAP) on the ulnar nerve and motor abilities in 34 SMA patients, aged between 1 and 16 years old, under nusinersen treatment, using specific motor scales for types 1, 2 and 3. The evaluations were performed at treatment initiation and 26 months later. There were registered increased values for CMAP amplitudes after 2 years of nusinersen, significantly correlated with motor function evolution in SMA type 1 patients (p < 0.005, r = 0.667). In total, 45% of non-sitters became sitters and 25% of sitters became walkers. For SMA types 1 and 2, the age at the treatment initialization is highly significant (p < 0.0001) and correlated with treatment yield. A strong negative correlation (r = −0.633) was observed for SMA type 1 and a very strong negative correlation (r = −0.813) for SMA type 2. In treated SMA cases, the distal amplitude of the CMAP and motor functional scales are important prognostic factors, and early diagnosis and treatment are essential for a better outcome.
Full Poincaré Mueller Polarimetry Using a CCD Camera
Authors: Suárez-Bermejo Juan Carlos , González de Sande Juan Carlos , Piquero Gemma , Failla Antonio Virgilio , Santarsiero Massimo
Published: September 2022

A new method is proposed to perform Mueller matrix polarimetry using a Full Poincaré beam (i.e., a non-uniformly polarized beam presenting all polarization states across its section) as a parallel polarization state generator and a charge-coupled device (CCD) camera as a detector of the polarization state analyzer. In this way, the polarization change is measured for all possible input states simultaneously. To obtain the Mueller matrix of the sample, the overdetermined system of equations that relates the input and output states of polarization is solved by means of the Moore–Penrose pseudo-inverse. Preliminary numerical simulations are performed to identify and exhaustively analyze the main sources of error. In order to test the method, experimental measurements are presented for several known samples, showing an excellent agreement between the experimentally obtained Mueller matrices and the theoretically expected ones.
Heat-Induced Emission Enhancement in a Yb:YAG Crystal-Derived Silica Fiber
Authors: Zou Kai , Wen Jianxiang , Wan Ying , Wu Yan , Pang Fufei , Wang Tingyun
Published: September 2022

We fabricated a Yb:YAG crystal-derived silica fiber (YCDSF) by the melt-in-tube method with a CO2 laser-heated drawing tower and explored the influences of the heat treatment method on fluorescent properties in the YCDSF. After the heat treatment, the intensity of the emission peaks and the fluorescence lifetime of the YCDSFs improved. In particular, after 1350 °C of heat treatment, a series of sharp peaks appeared in the core layer, which may form a new crystalline phase. Moreover, its emission intensity at 1030 nm was significantly enhanced, over 2 times greater than before the heat treatment. Additionally, the fluorescence lifetime of Yb ions was also increased from 129 to 621 μs, indicating the changes in local environments around Yb ions. Then, schematic models were set up to show how the local environments around Yb ions are gradually changing. These results revealed that the assessed YCDSF is of excellent performance; after the heat treatment, it may be a potential material for realizing optical amplification, light sources, fiber lasers, and so on.
Analysis of In Vivo Radachlorin Accumulation through FLIM-Assisted Examination of Ex Vivo Histological Samples
Authors: Belashov Andrey V. , Zhikhoreva Anna A. , Kruglov Stepan S. , Panchenko Andrey V. , Semenova Irina V. , Vasyutinskii Oleg S.
Published: September 2022

We report an investigation of the in vivo accumulation of Radachlorin photosensitizer in a murine model in several types of normal and tumor tissues based on an FLIM-assisted analysis of fluorescence intensity images, time-resolved fluorescence signals, and phasor plots. Experiments were performed on ex vivo histological samples of normal and tumor tissues. It was shown that the investigation of fluorescence intensity distributions combined with that of time-resolved fluorescence images can be used for qualitative and—under some limitations—quantitative analyses of the relative uptake of this photosensitizer in tissues. The phasor plot representations of time-resolved fluorescence signals were shown to be suitable for identification of the accumulation of predominant photosensitizers in tissues.
On Laminated Object Manufactured FDM-Printed ABS/TPU Multimaterial Specimens: An Insight into Mechanical and Morphological Characteristics
Authors: Kumar S. , Singh I. , R. Koloor S. S. , Kumar D. , Yahya M. Y.
Published: September 2022

Fused deposition modeling (FDM) printing of commercial and reinforced filaments is a proven and well-explored method for the enhancement of mechanical properties. However, little has hitherto been reported on the multi-material components, fused or laminated together into a single specimen by using the laminated object manufacturing (LOM) technique for sustainable/renewable polymers. TPU is one such durable and flexible, sustainable material exhibiting renewable and biocompatible properties that have been explored very less often in combination with the ABS polymer matrix in a single specimen, such as the LOM specimen. The current research work presents the LOM manufacturing of 3D-printed flexural specimens of two different, widely used polymers available viz. ABS and TPU and tested as per ASTM D790 standards. The specimens were made and laminated in three layers. They were grouped into two categories, namely ABS: TPU: ABS (ATA) and TPU: ABS: TPU (TAT), which are functionally graded, sandwiched structures of polymeric material. The investigation of the flexural properties, microscopic imaging, and porosity characteristics of the specimens was made for the above categories. The results of the study suggest that ATA-based samples held larger flexural strength than TAT laminated manufactured samples. A significant improvement in the peak elongation and break elongation of the samples was achieved and has shown a 187% increase in the break elongation. Similarly, for the TAT-based specimen, flexural strength was improved significantly from approximately 6.8 MPa to 13 MPa, which represents a nearly 92% increase in the flexural strength. The morphological testing using Tool Maker’s microscopic analysis and porosity analysis has supported the observed trends of mechanical behavior of ATA and TAT samples.
κ-Carrageenan Hydrogel as a Matrix for Therapeutic Enzyme Immobilization
Authors: Makshakova Olga N. , Bogdanova Liliya R. , Makarova Anastasiya O. , Kusova Aleksandra M. , Ermakova Elena A. , Kazantseva Mariia A. , Zuev Yuriy F.
Published: September 2022

During the last few decades, polysaccharide hydrogels attract more and more attention as therapeutic protein delivery systems due to their biocompatibility and the simplicity of the biodegradation of natural polymers. The protein retention by and release from the polysaccharide gel network is regulated by geometry and physical interactions of protein with the matrix. In the present work, we studied the molecular details of interactions between κ-carrageenan and three lipases, namely the lipases from Candida rugosa, Mucor javanicus, and Rhizomucor miehei—which differ in their size and net charge—upon protein immobilization in microparticles of polysaccharide gel. The kinetics of protein release revealed the different capability of κ-carrageenan to retain lipases, which are generally negatively charged; that was shown to be in line with the energy of interactions between polysaccharides and positively charged epitopes on the protein surface. These data create a platform for the novel design of nanocarriers for biomedical probes of enzymatic origin.
Effect of Hydrothermal Environment on Mechanical Properties and Electrical Response Behavior of Continuous Carbon Fiber/Epoxy Composite Plates
Authors: Zhu Runtian , Li Xiaolu , Wu Cankun , Du Longji , Du Xusheng , Tafsirojjaman T.
Published: September 2022

In this work, the effect of a hydrothermal environment on mechanical properties and the electrical response behavior of continuous carbon fiber/epoxy (CFRE) composite produced by the pultrusion method were investigated. Due to the relatively uniform distribution of fibers and lack of resin-rich interlayer area, this effect for the pultruded CFRE composite plates is different from the common CFRE laminated composites. Firstly, its hygroscopicity behavior was studied. The absorption ratio increases rapidly to 1.02% within 3 days before reaching a relatively stable state. A three-point bending test, a Vickers hardness test, a thermogravimetric analysis (TGA), and a scanning electron microscope (SEM) analysis were performed to investigate the effect of the hydrothermal environment on the mechanical properties and thermal stability of the CFRE composite. The results indicated that the bending strength decreased quickly within 3 days of hydrothermal treatment, followed by a stable trend, which coincided with that of the hygroscopicity behavior of the composites. The fracture surface analysis indicated that the interfacial properties of carbon fibers in the epoxy matrix were decreased after the hydrothermal treatment, and more carbon fibers could be pulled out from the CFRE in the hygroscopic state. After the hydrothermal treatment, the micro-hardness of the composites was reduced by 25%. TGA confirmed the decreased thermal stability of the CFRE composites after the hydrothermal treatment as well. Moreover, the hydrothermally treated CFRE composites could a reach stable resistance response more readily. The revealing of the effect of moisture and hot environment on the mechanical properties and electrical response behavior of pultruded CFRE composites prepares the ground for their design and practical application in the corresponding environment.
Influence of Novel Experimental Light-Cured Resin Cement on Microtensile Bond Strength
Authors: Kawamura Midori , Toida Yu , Hoshika Shuhei , Islam Md Refat Readul , Li Yitong , Yao Ye , Liu Yunqing , Islam Rafiqul , Sato Takaaki , Shimada Yasushi , Sano Hidehiko
Published: September 2022

The purpose of this study was to evaluate the microtensile bond strength (µTBS) and Knoop hardness number (KHN) of a novel experimental light-cured resin cement (HL). Eighteen flat dentin surfaces of human molars were polished using #600 SiC paper and bonded to CAD/CAM resin blocks with the respective resin cements and composites: HL, Panavia V5 (PV), and Clearfil AP-X (AP). All specimens were stored in distilled water at 37 °C for 24 h and 7 days. Scanning electron microscope (SEM) and energy dispersive X-ray (EDX) observations were performed to evaluate filler morphology and to detect the elements. The resin cements had a significant effect on the immediate µTBS (F = 22.59, p < 0.05) and after water storage µTBS (F = 22.83, p < 0.05). Significant differences (p < 0.05) in the KHN between the tested materials were observed, and HL indicated the highest KHN when compared with PV. HL showed a combination of the regular-shaped filler and spherical-shaped filler within the matrix. Silicon was detected in HL from the EDX evaluation. HL exhibited better bonding performance and polymerization, which may have contributed to the improvement of the adhesive strength.
Hydrophobisation of Silica Nanoparticles Using Lauroyl Ethyl Arginate and Chitosan Mixtures to Induce the Foaming Process
Authors: Krzan Marcel , Jarek Ewelina , Petkova Hristina , Santini Eva , Szyk-Warszynska Lilianna , Ravera Francesca , Liggieri Libero , Mileva Elena , Warszynski Piotr
Published: September 2022

We studied silica suspensions with chitosan and biodegradable synthetic surfactant lauroyl ethyl arginate (LAE). Hydrophilic and negatively charged silica nanoparticles were neutralised due to the coating with chitosan. That presence of LAE led to the partial hydrophobisation of their surface, which favoured their attachment to the surface of a thin foam film. It was found that the presence of small and medium-sized (6–9 nm) hydrophobic particles in the interfacial layer of lamella foam film inhibited the coalescence and coarsening processes, which prolonged the life of the foam. Furthermore, hydrophobising of 30 nm particles allowed the formation of large aggregates precipitating from the mixture under steady-state conditions. These aggregates, however, under the conditions of the dynamic froth flotation process in the foam column, were floated into the foam layer. As a result, they were trapped in the foam film and Plateau borders, effectively preventing liquid leakage out of the foam. These results demonstrate the efficiency of using chitosan-LAE mixtures to remove silica nanoparticles from aqueous phase by foaming and flotation.
Methylethynyl-Terminated Polyimide Nanofibrous Membranes: High-Temperature-Resistant Adhesives with Low-Temperature Processability
Authors: Qi Haoran , Ren Xi , Liu Yuang , Dai Shengwei , Yang Changxu , Wang Xiaolei , Liu Jingang
Published: September 2022

As an alternative to traditional riveting and welding materials, high-temperature-resistant adhesives, with their unique advantages, have been widely used in aviation, aerospace, and other fields. Among them, polyimide (PI) adhesives have been one of the most studied species both from basic and practical application aspects. However, in the main applications of solvent-type PI adhesives, pinholes or bubbles often exist in the cured PI adhesive layers due to the solvent volatilization and dehydration reaction, which directly affect the adhesive performance. To address this issue, electrospun PI nanofibrous membranes (NFMs) were employed as solvent-free or solvent-less adhesives for stainless steel in the current work. To enhance the adhesion of PI adhesives to the metal substrates, phenolphthalein groups and flexible ether bonds were introduced into the main chain of PIs via the monomers of 4,4′-oxydiphthalic anhydride (ODPA) and 3,3-bis[4-(4-aminophenoxy)phenyl] phthalide (BAPPT). At the same time, the methylethynyl group was used as the end-capping component, and the crosslinking reaction of the alkynyl group at high temperature further increased the adhesive strength of the PI adhesives. Three kinds of methylethynyl-terminated PI (METI) NFMs with the set molecular weights of 5000, 10,000, and 20,000 g/mol were first prepared via the one-step high-temperature polycondensation procedure. Then, the PI NFMs were fabricated via the standard electrospinning procedure from the soluble METI solutions. The afforded METI NFMs showed excellent melt-flowing behaviors at high temperature. Incorporation of the methylethynyl end-capping achieved a crosslinking reaction at 280−310 °C for the NFMs, which was about 70 °C lower than those of the phenylacetylene end-capping counterparts. Using the METI NFMs as adhesive, stainless steel adherends were successfully bonded, and the single-lap shear strength (LSS) was higher than 20.0 MPa at both room temperature (25 °C) and high temperature (200 °C).
The Effect of Seawater on Mortar Matrix Coated with Hybrid Nano-Silica-Modified Surface Protection Materials
Authors: Gu Yue , Fan Ruyan , Xia Kailun , Lyu Kai , Wei Zhenhua , Guo Mingzhi
Published: September 2022

Surface treatment technology is an effective method to reinforce the durability of concrete. In this study, cement-based materials containing industrial solid wastes were modified by hybrid nano-silica (HN), then applied as a novel surface protection material (SPM-HN). The effect of SPM-HN on surface hardness of mortar matrix exposed to seawater was investigated. Further, the microstructure was characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and mercury intrusion porosimetry (MIP). The results show SPM-HN could significantly enhance the surface hardness of matrix in seawater curing, and the rebound number is increased by 94%.The microstructure analysis demonstrates that the incorporation of HN inhibits the formation of ettringite, thaumasite, and Friedel’s salt. In addition, thermodynamic modeling shows the incorporation of hybrid nano-silica could generate more C-S-H, and decrease the maximum volume of Friedel’s salt when SPM is exposed to seawater. This research indicates SPM-HN can be applied as a concrete protective layer in the marine environment.
Opting out of Religious Education and the Religiosity of Youth in Poland: A Qualitative Analysis
Authors: Mąkosa Paweł Michał , Zając Marian , Zakrzewski Grzegorz
Published: September 2022

For several years now, a large number of secondary school students in Poland have given up Religious Education. The basic hypothesis is that the religiosity of young people is the main correlate with the abandoning of religion classes. In order to analyze this phenomenon, qualitative research was carried out in the form of in-depth interviews with secondary school students who had opted out of religion classes. The interviews were conducted in January and February 2022, with 29 students of randomly selected general secondary schools from various cities of Poland who had opted out of Religious Education. The technique called computer-assisted web interview (CAWI) was used. Young people were first asked about their reasons for giving up Religious Education, and then about their religiosity. The 16 questions in the interviews were divided into the following groups: attitude to Religious Education at school; and attitude to faith and religious practices, with reference to the Church and Catholic morality. These studies have shown that an increasing percentage of young people do not identify with the Catholic Church and do not want to participate in confessional Catholic Religious Education. The main conclusion of the study is to rethink the current concept of Religious Education in Poland so that it will be more open to students with different religious beliefs and worldviews.
Belief and Belonging: Ritual Ramifications of the Failed Assassination Attempts on Emperor Alexander II of Russia
Authors: Stephanov Darin
Published: September 2022

This article opens up a new scholarly subfield (royal-assassination-attempt commemoration) within the long-neglected field of annual (especially, provincial) ruler festivities in the nineteenth-century Russian Empire. It does so by subjecting an array of untapped, geographically dispersed sources to a systematic, highly theoretically underwritten analysis. As a result, the article generates many insights into the principles and pathways of pious thought and action of Russian imperial subjects from all walks of life vis-à-vis their monarch. In the process, it provides a methodological template for future studies of the intersections between belief and belonging going into the modern age, not only in Russia, but across the world.