bluuebunny/crossref_metadata_2025 huggingface dataset:
Primula meishanensis (Primulaceae), a new species from Sichuan, China
Authors: Li Tingyu , Chen Xinyu , Li Bo , Hua Donglai , Luo Can , Luo Huixian , Liang Yun , Yue Jieli , Xi Xiaodan , Huang Ke , Fu Zhixi
Published: October 2024

Primula meishanensis K.Huang & Z.X.Fu, sp. nov., a new species of Primulaceae from Meishan City, Sichuan Province, China, is described and illustrated. The morphological data and phylogenetic analysis, based on the complete chloroplast genome, suggest that Primula meishanensis is a separate species closely related to Primula dejuniana. The complete chloroplast genome of Primula meishanensis was 152,175 bp and the complete chloroplast genome of Primula dejuniana was 151,988 bp. The new species differs from the latter by the solitary scape, the length of petiole, acute leaf blade apex and pin flower. The distribution map, morphological comparison of related species and conservation status of the new species are also provided.
Prologue: Spondyloarthritis Unmet Research Needs Conference IV
Authors: Colbert Robert A. , Carroll Ellen , Dubreuil Maureen , Gensler Lianne S. , Haroon Nigil , Howard Richard , Ogdie Alexis R. , Shafer Cassie , Weiss Pamela F. , Kuhn Kristine A.
Published: October 2024

The Spondylitis Association of America (SAA) and the National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS) convened a conference on the campus of the National Institutes of Health (NIH) on September 28 and 29, 2023, to identify unmet needs in spondyloarthritis (SpA) research. The conference featured presentations by experts in areas of disease endotypes, pain, innovative imaging in SpA, health disparities in rheumatic diseases, and therapeutics. Members of the conference planning committee moderated the sessions and led the development of manuscripts summarizing recommendations to address unmet research needs. Early career investigators were invited to submit abstracts, which were presented at a networking session during the conference. Here, we highlight each of the sessions comprising the conference in the form of manuscripts published together as a conference summary.
Are There Disease Endotypes in Axial Spondyloarthritis and How Would We Define Them?
Authors: Deane Kevin D. , Donlin Laura T. , Ritchlin Christopher T. , Kuhn Kristine A.
Published: October 2024

Is axial spondyloarthritis (axSpA) one disease or does it comprise multiple types? If the latter, how do we define those types—through clinical or imaging features, HLA-B27 status, or by other immunologic features? Data comparing disease outcomes for individuals with nonradiographic vs radiographic axSpA, or for male vs female patients, demonstrate distinctions. So then, how should we define endotypes? Endotypes are known as the subtype of a health condition defined by a functional or pathophysiologic function. Here, we review the endotypes used for defining rheumatoid arthritis, asthma, and psoriatic arthritis. Taking the lessons learned from these diseases, we discuss how they can be applied to defining endotypes in axSpA. A key unmet need for axSpA is access to affected tissues for interrogation of their pathologic mechanisms, from which tissue-specific endotypes can be defined. These tissue-based features should be combined with clinical data and imaging to inform classification criteria in the future.
Enhancing Equity in Clinical Research: A Multifaceted Proposal for Spondyloarthritis
Authors: Dubreuil Maureen , Ferucci Elizabeth D. , El-Gabalawy Hani , Hasni Sarfaraz , Williams Edith M.
Published: October 2024

Clinical research advances medical knowledge and improves healthcare outcomes. However, disparities in research participation hinder progress. The Unmet Research Needs in Spondyloarthritis Conference IV highlighted critical insights and strategies to enhance equity in clinical research. Talks focused on engaging underrepresented communities and addressing disparities in rheumatic diseases, particularly spondyloarthritis (SpA), to ensure research results are generalizable and inclusive. Disparities in SpA management, such as greater back pain severity among Black and Hispanic Americans and sex-based differences in pain management, emphasize the need for equitable research. Dr. Elizabeth Ferucci discussed the racial disparities in rheumatologic care, highlighting the importance of early access to rheumatologists and culturally informed primary care to improve outcomes. Dr. Hani El-Gabalawy’s talk on engaging Indigenous communities stressed the importance of community consent and reciprocal benefits. Dr. Sarfaraz Hasni’s presentation on mitigating disparities in research participation underscored the need for inclusive practices and strategies to promote diverse representation. Finally, Dr. Edith Williams emphasized institutional approaches to fostering equity, including diverse recruitment practices and institutional review board alignment with diversity priorities. Strategies to enhance equity in clinical research include community engagement, addressing logistical barriers to participation, and ensuring diverse research teams. These approaches can dismantle barriers for underrepresented communities, making research more accessible and reflective of the broader population. The SpA research community must commit to creating structures that foster inclusivity, ensuring medical advancements benefit all populations, especially historically underrepresented groups. The principles and strategies proposed serve as a roadmap for achieving equity in SpA research.
Kidney transplantation in the elderly
Authors: Park Byung Hwa , Kil Song Yi , Kim Ye Na , Shin Ho Sik , Jung Yeonsoon , Rim Hark
Published: October 2024

Interest in kidney transplant studies in the elderly population is increasing as more research has been conducted on the immune system. With this review, we hope to encourage the need for research on kidney transplantation in the elderly.
Les étudiants anglais à Douai et Saint-Omer (1568-1603) : réseau transnational et insertions locales du refuge catholique
Authors: Junot Yves
Published: October 2024

L’activation d’un refuge de dissidents catholiques anglais dans les Pays-Bas espagnols donne naissance au modèle du collège-séminaire regroupant la diaspora ecclésiastique et universitaire dans une « dorsale académique » dont Douai et Saint-Omer deviennent des pivots. Leur but est de former de nouvelles générations cléricales et laïques pour assurer le renouvellement d’une élite catholique en Angleterre et appuyer une éventuelle succession catholique d’Élisabeth I ère . Ces groupes d’étudiants ne s’assimilent pas dans leur société d’accueil, provisoire par définition. Ils maintiennent leur spécificité par le marqueur national mais aussi confessionnel tridentin et jésuite, et par leur hispanophilie au service de la monarchie de Philippe II et des ultra-catholiques de la Ligue en France, jouant de leur implantation aux frontières de France et d’Angleterre. Leur action en réseaux transnationaux explique aussi les rejets locaux dont ils sont parfois victimes, avec leur expulsion de Douai en 1578 et leur repli de France vers Douai et Saint-Omer en 1593.
« Migrations africaines, circulations et imaginaires migratoires ». Compte rendu de la journée d’étude pluridisciplinaire du laboratoire MIGRINTER, Poitiers, le 26 mars 2009
Authors: Garnier Julie , Lassailly-Jacob Véronique , Sall Leyla
Published: October 2024

Cette journée d’études poursuit la réflexion engagée depuis 1990 par le laboratoire Migrinter sur la circulation migratoire, le transnationalisme et les déplacements forcés. Pour approfondir ce questionnement, nous avons souhaité recentrer la réflexion sur les rapports entre imaginaires1 et circulations migratoires.
L’archive ouverte HAL-SHS : Comment ça marche, pourquoi s’en servir ?
Authors: Abela Caroline
Published: October 2024

Tired of having your work locked in the ivory tower? Break out1. C’est ainsi que le mouvement du libre accès à l’information scientifique incite les chercheurs à sortir du modèle économique des publications payantes pour rendre leur production accessible au plus grand nombre. Cette incitation obéit à deux logiques qui s’entrecroisent : d’une part la documentation scientifique est coûteuse, d’autre part le libre accès à l’information scientifique est devenu un enjeu de société, un appel humaniste au partage de la connaissance considérée comme « bien commun ». Dans ce contexte, les archives ouvertes ont pour vocation de faciliter la communication des résultats de la recherche.
Rechercher l’asile en Europe (1974 - 2009)
Authors: Clochard Olivier
Published: October 2024

Les ouvrages et les articles en langue française, anglaise, espagnole et italienne sur les demandeurs d’asile et les réfugiés en Europe sont nombreux, que ce soit dans le champ scientifique ou dans celui des associations et des Ong. À cela s’ajoutent des rapports d’institutions internationales comme le Hcr, Ecre ou le Conseil de l’Europe, qui présentent et analysent la problématique à une échelle nationale ou européenne, voire à partir d’un thème. Et depuis une dizaine d’années, la recherche de publications sur Internet est devenue une artère incontournable pour celles et ceux qui s’intéressent à l’asile.
« Logement et représentations du logement pour les migrants et populations itinérantes »
Authors: Hoyez Anne-Cécile
Published: October 2024

Ce séminaire, le troisième des quatre dans le cadre du programme franco-britannique « Migration, santé et bien-être », a eu pour objet l’accès au logement et ses impacts en matière de santé et de bien-être, en France et en Grande-Bretagne, pour les populations migrantes et itinérantes1. Les conditions matérielles de logement sont en effet souvent citées comme l’un des déterminants de la santé et du bien-être.
Parcours migratoires des mineurs isolés étrangers, catégorisation et traitement social de leur situation en France
Authors: Etiemble Angelina
Published: October 2024

Cette communication a pour objet une réflexion sur l’interaction entre les motifs, réels ou supposés, du départ du pays d’origine des mineurs isolés étrangers et le traitement social de leur situation en France, en particulier tel qu’il apparaît à travers les pratiques professionnelles des acteurs de la Protection de l’Enfance.
Unleashing Ethical Issues in Neurodisorder Diagnosis
Authors: Singh Bhupinder , Kaunert Christian , Malviya Rishabha , Arora Manmeet Kaur , Lal Sahil
Published: October 2024

The advancements in computational intelligence have revolutionized the diagnosis of neurodisorders, paving the way for more precise and personalized psychiatric therapy. However, this progress raises significant ethical concerns and requires careful consideration. With integrating machine learning and AI into neurodisorder diagnosis and treatment, computational intelligence is set to enhance diagnostic accuracy and enable more individualized care plans, allowing for earlier interventions. The methodological innovations in the computational intelligence techniques have revolutionized some aspects of neurodisorder diagnosis which, according to evidence, should be considered especially by providing a more accurate and personalized psychiatric treatment. But this advance also raises crucial ethical issues that need to be addressed with caution.
Social Inclusion Tactics for People With Intellectual and Developmental Disabilities
Authors: Goronga Pedzisai , Mashiri Webster
Published: October 2024

This chapter examined the psychological experience of learners with intellectual and developmental disabilities (IDD). It explored the unique strengths, challenges, and resilience demonstrated by this population. The chapter highlighted the cognitive, emotional, and social dimensions of living with an IDD. Key issues included self-concept development, strategies for emotion regulation, the impact of societal attitudes, and the role of family and community support systems. Ultimately, the chapter provided a nuanced, empathetic perspective on the lived experiences of people with IDD and to dispel common misconceptions. Clinicians, educators, policymakers, and the general public can benefit from the insights presented to foster greater inclusion and improve the quality of life for this vulnerable yet resilient population. The development and promotion of intervention programmes tailored to the unique socio-cultural context of individuals with intellectual and developmental disabilities (IDDs) in Zimbabwe are recommended.
Empowering Organizations Through Adaptation With the Learning Loop
Authors: Dandona Anu
Published: October 2024

In today's business world, adaptability is imperative for survival. This chapter explores the “Learning Loop,” vital for navigating change, fostering innovation, and ensuring growth. It delves into core principles, strategies, and real-life examples, illustrating how the Loop enables continuous learning, unlearning, and adaptation. Through case studies, it shows how businesses leverage it to thrive, driving innovation and sustainable growth in uncertain environments. Ultimately, the Learning Loop emerges as a robust approach for organizations to realize their potential amidst complexity and uncertainty.
Learning Loops and the Process of Continuous Improvement
Authors: Lakshmi H. , Ajay Shilpa
Published: October 2024

Learning loops summarize the iterative process of continuous improvement, emphasizing the importance of ongoing learning and adaptation in response to internal and external stimuli within organizations. They serve as dynamic feedback mechanisms, enabling organizations to understand, explore novel methods, and iterate on their processes. This chapter explores the mission of learning loops to promote adaptive learning cultures and their concerns about resistance to change, organizational inertia, and effective feedback mechanisms. Implementing learning loops requires a cultural shift towards openness, experimentation, and learning from failure, which can meet skepticism from employees used to hierarchical structures. Overcoming this resistance needs strong leadership, effective communication, and psychological safety and robust feedback mechanisms. Through strategic leadership, cultural transformation, and investment in learning infrastructure, organizations can harness learning loops for consistent growth and excellence.
Breaking the Glass Ceiling
Authors: Andrabi Ulfat , Chhibber Priyanka , Gani Raashidah , Qazi Atif Javed
Published: October 2024

The phrase "glass ceiling" describes the hidden obstacles that keep women from rising to authority of leadership. Apart from a basic human right, gender equality is absolutely essential for reaching sustainable development and building a fair society. Though great progress has been achieved in recent years, gender equality is still a difficult and elusive target in many societies all around. The complete realization of an inclusive and diverse working environment is impeded by gender discrepancies.
Higher Education's Place and Space in Society
Authors: Crawford Caroline M. , Dillard James L.
Published: October 2024

Higher education's place and space within the cultural milieu of society reflects a previously deft organizational maneuverability. The history as an elastic and responsive organization supported the acquisition and disbursement of knowledge within the larger society and offering the perception of a greater good as a value statement. Yet within more recent decades, the viability and value of the higher education organization has been discussed as a questionable entity that may or may not be a viable organization within the developing generations of citizenry and within the digital age within which artificial intelligence and other forms of large language models step into the more easily replaced and replicated responsibilities of employment. This work presents a multiple case study approach, reflecting a deeply personal and professional journey through higher education organizations, with narratives towards the ability of an educational institution to learn, unlearn, and maneuver to meet the needs of the larger societal and cultural needs.
Unlearning for Organizational Resilience and Adaptation.
Authors: Bhanot Neeraj , Sharma Rahul
Published: October 2024

In an era of rapidly changing technology and uncertain market conditions, the need for organizational resilience is very important. Organizational unlearning is one such capability that has become increasingly important for adaptability and innovation since it involves eliminating outdated knowledge to embrace new ideas. Despite its significance, little is known about different forms of unlearning and their benefits to practice. This study aims to bridge this gap by doing a bibliometric analysis of the organization's unlearning. Web of Science and Scopus databases were used to analyze intellectual maps using co-citation, bibliographic coupling and co-occurrence analysis. The results show significant growth in research, pointing out major publications and shift in thematic trends. A strong thematic connection is observed that exist among cited works, and highlight unlearning as a promoter of innovation, strategic change and flexibility. This study enhances understanding of organizational unlearning theory and its applications, offering a concise review and future research directions.
Edible Electronics for Smart Technology Solutions
Authors: Hemanth Babitha , Meghashree Meghashree , Sanjay P. K. (dfcfcaa8-1eca-48f1-a106-cc836dcd53ab  , Kalungade Rutesh R.
Published: October 2024

The advent of edible electronics marks a groundbreaking advancement in the field of food packaging, ushering in a new era of sustainability, functionality, and consumer engagement. This abstract explores the transformative potential of edible electronics and its implications for the food industry. Edible electronics represent a paradigm shift where traditional packaging materials are augmented with electronic components, rendering them not only biodegradable but also functional beyond containment. By seamlessly integrating sensors, actuators, and other electronic elements into edible substrates, such as films or coatings, these innovative packaging solutions offer unparalleled benefits. One of the primary advantages of edible electronics is their ability to extend the shelf life of perishable goods through real-time monitoring of environmental conditions. This ensures optimal storage conditions and reduces food waste, addressing a critical challenge in the global food supply chain.
Advancements in Edible Electronics and Robotics for Smart Food Packaging Processes
Authors: J. Sudhakara Rao , Behera Gitanjali , K. S. Shreenidhi , Anandaram Harishchander , Mani G. Durai Muthu
Published: October 2024

This chapter explores recent advancements in edible electronics and robotics for smart food packaging, focusing on sustainability, food safety, and consumer interaction. Edible electronics, designed for human consumption, offer new applications in food quality monitoring, including real-time detection of spoilage, monitoring nutritional content, and product authentication, thereby enhancing food safety Robotics and other technologies will enable innovative functionalities like dynamic packaging responses, automated freshness indicators, and active interventions to extend shelf life. The chapter delves into the intricacies of edible sensors and robotic systems, examining their materials, technologies, design, regulatory, safety, and ethical implications. The study explores the potential of IoT in packaging for supply chain management, personalized nutrition, and waste reduction, highlighting its integration into digital ecosystems, presenting a shift in food distribution, safety, and sustainability.
From Ingestible to Edible
Authors: Dey Snehasis
Published: October 2024

Edible electronics symbolize a departure from the traditional concept of ingestible electronics, characterized by devices that are not only tailored for ingestion but also completely disintegrate in the body and can be safely released into the environment without the need for retrieval. In recent years, there has been a swift progression in the field of Green Electronics, marked by a significant rise in the number of research groups showcasing remarkable achievements in the realm of edible and biodegradable electronics. On this context this chapter caters to the study of edible electronics, its physical characterization and their role in environment monitoring. Thus, researchers are putting hard time out to discover the development of electronic components from food waste which controls the wastage and creation of proper sustainable approach towards edible electronics which also monitors the environment. This chapter dives into the edible electronics role in environment monitoring as well as its future advancement and current research.
A Bibliometric Study of Social Innovation and Sustainable Territorial Development
Authors: El Maaqili Younes , Ouchen Abdessamad
Published: October 2024

This article examines the evolution of research on social innovation and sustainable territorial development in the context of a multiplication of studies in this field. Despite this increase in research publications, a gap remains in the understanding of key trends and research orientations, as well as their alignment with immediate environmental needs. To address this gap, a bibliometric analysis was carried out to examine scientific publications, highlighting a steady growth in research with a diversification of topics covered. The results highlight a steady growth in research, with a diversification of topics covered, such as rural development initiatives, innovative practices for a socially responsible economy and sustainable development objectives. The implications of this research underline the importance of continuing research in this field, focusing on specific areas such as the comparison of rural development policies and support programs for social innovation, and the integration of sustainable development objectives into organizational practices.
Inclusive Education in the Artificial Intelligence Era
Authors: Salhab Reham Ahmed
Published: October 2024

This chapter delves into the influence of Artificial Intelligence (AI) on inclusive education. This chapter explores how AI might support inclusive education. Moreover, it delves into challenges of this support. To achieve this, a phenomenological qualitative approach is adopted. Experiences with qualitative approach was used. Engaging 45 college instructors from diverse academic specialties, qualifications, and experiences. This study conducted three focus group sessions and 15 semi structured interviews. Thematic analysis was used to analyze data. For opportunities, three themes emerged: AI tailored experience with five subthemes, improved accessibility, and insights into Students' Needs. Three themes also emerged for challenges: algorithm bias, data privacy, and professional development. More empirical studies should be conducted with different groups.
Adopting AI in Education
Authors: Kaddouri Mehdi , Mhamdi Khalid , Chniete Ilham , Marhraoui Meriem , Khaldi Mohamed , Jmad Sabrine
Published: October 2024

Artificial intelligence (AI) is profoundly transforming the way we live and work, raising ethical, legal, and social questions. This chapter examines the technical and ethical implications of AI in education. Technical challenges are categorized into three key areas: infrastructure and implementation, data collection and management, and the development of tailored algorithms. A contextualized approach and customized training are essential to avoid inappropriate pedagogical decisions. Critical ethical issues include privacy protection, equity, and transparency of AI systems. Three strategic axes for the ethical adoption of AI are presented: establishing appropriate regulatory and policy frameworks, training and raising awareness among relevant stakeholders, and the ethical design of AI systems. The chapter concludes with perspectives on integrating AI into immersive learning environments, requiring a systemic redesign of pedagogical approaches, teacher training programs, and educational curricula.
Enhancing GeoHealth: A step-by-step procedure for spatiotemporal disease mapping
Authors: Roelofs Bart , Weitkamp Gerd
Published: October 2024

Cartography, or geographical visualization of disease is an essential aspect of the field of GeoHealth, yet there is limited guidance on the visualization of spatiotemporal disease maps. In order to adequately contribute to understanding disease outbreaks, disease maps should be crafted carefully and according to relevant cartographic guidelines. This article aims to increase the understanding of space-time visualization techniques that are relevant to the field of GeoHealth, by providing a step-by-step framework for the creation of space-time disease visualizations. This study introduces a systematic approach to spatiotemporal disease mapping by integrating operations from the Generalized Space Time Cube (GSTC) Framework with established cartographic symbology guidelines. This resulted in an overview table that contains both the relevant GSTC operations and cartographic guidelines, as well as a step-by-step procedure that guides users through the process of creating informative spatiotemporal disease maps. The practical application of this step-by-step procedure is demonstrated with an example using Dutch COVID-19 data. By providing a clear, practical step by step procedure, this study enhances the capacity of public health professionals, policymakers, and researchers to monitor, understand, and respond to the spatial and temporal dynamics of diseases.
Almost equivariant maps for td-groups
Authors: Bartels Arthur Clemens , Lück Wolfgang
Published: October 2024

We construct certain maps from buildings associated to td-groups to a space closely related to the classifying numerable

G

-space for the family

\mathcal{C}\mathrm{vcy}

of covirtually cyclic subgroups. These maps are used elsewhere to study the K-theory of Hecke algebras in the spirit of the Farrell–Jones conjecture.
Central limit theorems and the geometry of polynomials
Authors: Michelen Marcus , Sahasrabudhe Julian
Published: October 2024

Let

X \in \{0,\ldots,n \}

be a random variable with mean

\mu

, standard deviation

\sigma

, and let

f_{X}(z) = \sum_{k}\mathbb{P}(X = k) z^{k}

be its probability generating function. Pemantle conjectured that if

\sigma

is large and

f_{X}

has no roots close to

1\in \mathbb{C}

, then

X

must be approximately normal. We completely resolve this conjecture in the following strong quantitative form, obtaining sharp bounds. If

\delta = \min_{\zeta}|\zeta-1|

over the complex roots

\zeta

of

f_{X}

, and

X^{\ast}:= (X-\mu)/\sigma

, then

\sup_{t \in \mathbb{R}}|\mathbb{P}(X^{\ast}\leq t) - \mathbb{P}( Z \leq t) | = O(({\log n})/({\delta\sigma}))

, where

Z \sim \mathcal{N}(0,1)

is a standard normal variable. This gives the best possible version of a result of Lebowitz, Pittel, Ruelle and Speer. We also show that if

f_{X}

has no roots with small
argument
, then

X

must be approximately normal, again in a sharp quantitative form: if we set

\delta = \min_{\zeta}|{\arg(\zeta)}|

, then

\sup_{t \in \mathbb{R}}|\mathbb{P}(X^{\ast}\leq t) - \mathbb{P}( Z \leq t)| = O({1}/({\delta\sigma}))

. Using this result, we answer a question of Ghosh, Liggett and Pemantle by proving a sharp multivariate central limit theorem for random variables with real-stable probability generating functions.
Enhancing the functionality of mesenchymal stem cells: An attractive treatment strategy for metabolic dysfunction-associated steatotic liver disease?
Authors: Shan Xiao-Qian , Zhao Lan
Published: October 2024

The intrinsic heterogeneity of metabolic dysfunction-associated fatty liver disease (MASLD) and the intricate pathogenesis have impeded the advancement and clinical implementation of therapeutic interventions, underscoring the critical demand for novel treatments. A recent publication by Li et al proposes mesenchymal stem cells as promising effectors for the treatment of MASLD. This editorial is a continuum of the article published by Jiang et al which focuses on the significance of strategies to enhance the functionality of mesenchymal stem cells to improve efficacy in curing MASLD, including physical pretreatment, drug or chemical pretreatment, pretreatment with bioactive substances, and genetic engineering.
Developmental assets and hedonic well-being among youths: In the perspective of students’ characteristics
Authors: Dejenie Meseret Ayalew , Getahun Dawit Asrat , Abebe Amare Sahle
Published: October 2024

This study examined the effect of gender and school types on developmental assets and hedonic well-being, encompassing positive affect, negative affect, and life satisfaction. The sample consisted of 614 randomly selected students from private, public, rural, and urban secondary schools. Data were collected using adapted items from life satisfaction, positive and negative affect, and developmental asset profile scales. The analysis employed Pearson correlation, two-way ANOVA, one-way ANCOVA, and two-way MANOVA. The results indicated no significant correlation between academic achievement and internal assets or life satisfaction. However, the interaction and main effect of gender and school type on internal asset experiences was significant. Additionally, the scores for internal and external asset profile scores varied significantly as a function of gender and private, public rural and public urban schools. The MANOVA result further revealed significant differences in positive affect, negative affect, and life satisfaction concerning gender and school type. It is concluded that students in the rural context have significantly better experience of internal and external asset profiles than students in private and public urban schools. This suggests the need for a thorough investigation of Context-based assets of rural areas, and their adaptation for application in urban settings.
Effect of sacubitril and valsartan combined with conventional therapy on patients with heart failure
Authors: Wu Zhenyu , Cui Wen , Li Guoliang , Li Ling , Bian Yi
Published: October 2024

Purpose: To investigate the clinical effectiveness of the combination of sacubitril and valsartan with conventional therapy in the  treatment of patients with heart failure.
Methods: This was a retrospective study comprising 100 heart failure patients randomized into  study (n = 57) and control groups (n = 43). The study group received sacubitril/valsartan along with conventional drug therapy while  control group received only conventional drugs, viz, irbesartan, metoprolol slow release, and furosemide tablets. Echocardiogram  showing left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), left anterior descending artery  (LAD), Nterminal pro-b-type natriuretic peptide (NT-proBNP), C-reactive protein (CRP), glomerular filtration rate (eGFR), and  homocysteine (HCY) of the two groups were compared before and after treatment. Multiple regression was used to analyze the  correlation between re-hospitalization and sacubitril/valsartan intervention.
Results: The study group showed significantly lower LVEF,  LVESD, LVEDD, LAD, NT-proBNP, and homocysteine levels after treatment compared to control group (p < 0.05). Re-hospitalization for abnormal cardiovascular events between the two groups was significantly different in the adjusted Cox proportional hazards regression  model. Furthermore, multiple regression analysis showed that sacubitril/valsartan treatment was the independent variable (p < 0.001). 
Conclusion: Sacubitril/valsartan improves heart function, with reduced incidence of adverse effects without affecting renal function.  Further studies are required to validate these findings by expanding sample size, strictly controlling data quality and strengthening  follow-up.
Effect of N-acetylcysteine in treatment of COPD with pulmonary interstitial fibrosis, inflammatory factors and VEGF levels
Authors: Yang Jie , Cai Yuanping , Lu Qiaofa , Zhang Bo
Published: October 2024

Purpose: To investigate the efficacy of N-acetylcysteine as an adjuvant therapy in chronic obstructive pulmonary disease (COPD) with  pulmonary interstitial fibrosis (PIF), and its effect on inflammatory factors and serum vascular endothelial growth factor (VEGF) levels.
Methods: A total of 94 patients with COPD-PIF from May 2020 to May 2022 in Wuhan Fourth Hospital, China were equally randomized into  study and control groups. Control group was administered conventional treatment while the study group was given N-acetylcysteine  in addition to conventional treatment. Therapeutic efficacy, forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), FEV1/FVC, blood gas, pulmonary fibrosis, and oxidative stress were evaluated. Changes in inflammatory factors, serum  vascular endothelial growth factor (VEGF), and incidence of adverse drug reactions were compared.
Results: The study group showed  significantly higher efficacy, FEV1, FVC, FEV1/FVC compared to control group (p < 0.05). Also, study group showed significantly higher  partial pressure of oxygen (PaO2), blood oxygen saturation, superoxide dismutase (SOD), and glutathione (GSH) levels after treatment  compared to control group (p < 0.05). Platelet-derived growth factor (PDGF), transforming growth factor (TGF-β), vascular cell adhesion  molecule (VCAM), tumor necrosis factor (TNF), interleukin-6 (IL-6), and vascular endothelial growth factor (VEGF) levels after treatment  were significantly lower in the study group than in the control group (p < 0.05).
Conclusion: N-acetylcysteine as an adjuvant therapy for  COPD-IF is highly effective, improves lung function and oxidative stress, reduces airway inflammation, and VEGF, and attenuates the  degree of hypoxia and pulmonary fibrosis with no serious adverse effects. A larger sample size, multicenter, randomized trials to validate  these findings and evaluate the downstream regulatory mechanism of Nacetylcysteine in COPD-PIF.
Ling gui shen fu decoction ameliorates cardiac injury in ischemic heart disease rats by regulating ANP32A/HIF2α/HMGB1 signal route
Authors: Gong Juanfen , Chen Yuanyuan
Published: October 2024

Purpose: To investigate the effect of ling gui shen fu decoction (LGSFD) on cardiac injury and cardiomyocyte apoptosis in rats with  ischemic heart disease (IHD), and to elucidate the underlying molecular mechanism.
Methods: An IHD rat model was established by performing coronary artery occlusion surgery on the left anterior descending (LAD) of  rats. The rats were assigned equally to 5 groups: sham-operated group (sham group), IHD group, IHD + perindopril group, IHD + low- dose LGSFD group (IHD + LGSFD-L group), and IHD + high-dose LGSFD group (IHD+LGSFD-H group). The LGSFD was given via gavage. A  hypoxia-induced cardiomyocyte model was established by subjecting H9C2 cells to hypoxia. Then, LGSFD-containing serum or blank  serum was used to treat the hypoxic rat cardiomyocytes (H9C2). The severity of cardiac injury and extent of apoptotic changes in  cardiomyocytes was determined using hematoxylin-eosin (H&E) staining and TUNEL staining, while immunoblotting was used to  measure the protein expressions of ANP32A, p-AKT, AKT, HIF-2α, p-mTOR, mTOR and HMGB1.
Results: The cardiac injury of rats in the  LGSFD groups was significantly reversed, relative to the IHD group (p < 0.05). Moreover, LGSFD reduced the level of apoptosis in hypoxia- induced H9C2 cells and upregulated the concentrations of ANP32A, p-AKT, HIF-2α and p-mTOR. However, the expression levels of HMGB1  were decreased in the heart tissues of IHD rats and hypoxic H9C2 cells. Silencing of ANP32A with ANP32A siRNA (siANP32A) down- regulated ANP32A, p-AKT, HIF-2α and p-mTOR, but up-regulated apoptosis and expression levels of HMGB1 in hypoxic H9C2 cells.  
Conclusion: LGSFD ameliorates cardiac injury in IHD rats by inhibiting cardiomyocyte apoptosis via the ANP32A/HIF-2α/HMGB1 axis.  Further investigations are recommended into the specific mechanism of LGSFD effect using clinical samples, in order to facilitate its  clinical development.
Efficacy of Sini SAN combined with Sijunzi decoction in tic disorder, and intestinal microbiota in children
Authors: Guo Jianbo , Han Yangfei , Hao Feng , Song Lina , Zhang Wei
Published: October 2024

Purpose: To evaluate the efficacy of Sini SAN and Sijunzi decoction in tic disorder, and intestinal microbiota in children.
Methods: This study enrolled 100 children with tic disorder from April 2020 to January 2023 in First Affiliated Hospital of Heilongjiang  University of Chinese Medicine, Harbin, China. The control group (n = 45) was administered tiapride hydrochloride 50 mg daily, (gradually  increased to thrice daily over 1 - 3 months, then reduced to once daily for 1 month, with a total treatment duration of 6 months). On the other hand, the study group (n = 55) received tiapride hydrochloride in addition to traditional Chinese medicine (TCM), including Sini San  and Sijunzi decoction with specific herbs (Radix pseudostellariae, white peony), for 6 months. Efficacy, TCM syndrome scores, Yale Global  Tic Severity Scale (YGTSS) scores, amino acid neurotransmitter levels, and α-diversity of intestinal microbiota were assessed in both  groups before treatment and at 4th and 8th weeks after commencement of treatment.
Results: There was no significant difference in  baseline characteristics between the study and control groups, indicating comparability (p > 0.05). The study group had a significantly  higher total effectiveness/efficacy (p < 0.05). It exhibited greater improvements in Traditional Chinese Medicine (TCM) syndrome scores  and YGTSS scores in the 4th and 8th week of treatment compared to control group (p < 0.05). Additionally, the study group exhibited  significant decrease in glutamate and aspartate levels and a significant increase (p < 0.05) in α-diversity of intestinal microbiota except for  Simpson index (p > 0.05).
Conclusion: The combination of TCM and tiapride hydrochloride improves efficacy, modulates neurotransmitter levels, alleviates symptoms, and improves α-diversity of intestinal microbiota.
Protective effect of evodiamine on acetic acid-induced gastric ulcers in rats through regulation of ROS/ICAM1/Nrf2 signaling pathway
Authors: Trinh Pham Thi Nhat , Dung Le Tien , Ngoc Pham Hong , Trang Nguyen Thi Thuy , Khoa Nguyen Cuu , Anh Hoang Ngoc , Osipov Alexey V. , Cheremnykh Elena G. , Utkin Yuri N.
Published: October 2024

Purpose: To investigate the anti-inflammatory and antiprotozoal effects as well as chemical profile of ethanol extracts of Hedyotis diffusa  (Rubiaceae) (HDE) and Scutellaria barbata (Lamiaceae) (SBE).
Methods: Dried whole plants collected in Vietnam were extracted with ethanol (30 and 96 %) by maceration for 4 weeks. The resulting  extracts obtained after evaporating the solvent were stored in a refrigerator at 4 oC. Mouse carrageenan-induced inflammation and  mouse macrophage cell line RAW264.7 were used to assess the in vivo and in vitro anti-inflammatory activities, respectively, while ciliate,  Tetrahymena pyriformis was used to determine antiprotozoal effects. Ultra-high-performance liquid chromatography coupled with  quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) was employed to analyze the chemical profiles of the extracts.
Results:  All the extracts manifested anti-inflammatory effects in vitro and in vivo. The HDE exhibited significantly higher in vitro anti-inflammatory  activity than SBE (p < 0.05). Furthermore, in vivo antiinflammatory activity was higher in SBE compared to HDE. Both extracts exhibited  antiprotozoal effects. The 96 % ethanol extract of both plants were more active than the 30 % ethanol extracts. Analysis by UHPLC‐Q‐TOF- MS revealed the presence of chrysin, apigenin and apigenin derivatives, naringenin, wogonin, quercetin and quercetin derivatives, as well  as scutellarin.
Conclusion: The HDE and SBE extracts from Vietnam exhibit significant in vivo and in vitro antiinflammatory activities  and in addition, antiprotozoal activity against Tetrahymena pyriformis. These plants, therefore, are potential sources of antiprotozoal  agents.
Dissolution of metals in NCM622 cathode through the Dissimilatory process with Na-lactate by Shewanella putrefaciens
Authors: Park Sang-Hee , Jung Haesung
Published: October 2024

Objectives:The objective of this study is to confirm the possibility of reduction and consequent dissolution of Li, Ni, Co, and Mn from NCM622 cathodes in spent Li-ion batteries through the anaerobic respiration with Na-lactate by Shewanella putrefaciens.Methods:The method involves using anaerobic microbial respiration to mimic dissimilatory metal oxide reduction, allowing metals to be leached from NCM622 cathodes (LiNi0.6Co0.2Mn0.2O2) under near-neutral pH conditions (~7.5).Results and Discussion:The results show that approximately 26 wt% of the total Li, Ni, Co, and Mn were successfully leached into the solution within two weeks. This approach differs significantly from conventional acidic leaching processes, offering a more environmentally friendly and sustainable alternative. In addition, we provide quantitative information regarding the dissolution of NCM622 when it is exposed in environmental systems.Conclusion:In conclusion, microbial-based metal leaching presents a novel, sustainable pathway for recovering metals from spent Li-ion batteries, addressing environmental concerns and reducing dependence on traditional energy-intensive recovery methods.
Non-State Actors in Asymmetric Conflicts: What does It Mean and What Follows of It
Authors: Deriglazova L. V.
Published: October 2024

The article examines the problem of the participation of non-state actors in armed conflicts in the post-war period. The study is based on the theory of asymmetric conflict, which offers hypotheses about the reasons for the paradoxical defeat of developed countries against relatively weak opponents, including non-state actors. The empirical basis of the study is armed conflict databases, which allow us to test sole observations and hypotheses about the characteristics of asymmetric armed conflicts. The study uses the databases of the Uppsala Conflict Data Program Project (Sweden) and the COSIMO Project (University of Heidelberg, Germany) as well as publications of the Stockholm International Peace Research Institute (SIPRI). The study shows that the phenomenon of asymmetric conflicts reflects several important patterns of armed conflicts in the post-war period: the predominance of intrastate over interstate conflicts; the internationalisation of armed conflicts through the involvement of other countries, international organisations or non-state actors; the direct or indirect involvement of great powers in such conflicts; and the majority of armed conflicts occurring in Asia, Africa and the Middle East. Post-war armed conflicts are often referred to as “proxy wars” because the direct participants in the conflict are supported by external actors –  states or non-state actors.  The issues in conflicts between states and non-state actors are often political in nature, and the fundamental distinction between domestic and foreign policy has been overcome. The post-war period shows a gradual change of attitude towards the participation of non-state actors in armed conflicts, which reflects the recognition of their legitimacy as participants in the conflict, the negotiation and conclusion of agreements on the cessation of hostilities. Non-state actors in armed conflicts are themselves legitimised as representing the interests of particular groups and the goals of their struggle. UN peacekeeping operations since the end of the Cold War confirm these changes. Research on the participation of non-state actors in armed conflict reveals a broadening of the agenda and methodology for the study of post-war armed conflict, reflecting significant changes in the practice of international relations. These changes concern who is recognised as a legitimate actor in international relations, what role non-state actors play in armed conflict, and how non-state actors are viewed by other actors in international relations – states, international governmental and non-governmental organisations.
Caseous Lymphadenitis in sheep and goats – “Cheese Glands”
Authors: Dopuđ Maja , Reil Irena , Zdelar-Tuk Maja , Špičić Silvio , Duvnjak Sanja
Published: October 2024

Caseous lymphadenitis (CLA) is a chronic infectious disease that affects small ruminants and is caused by Corynebacterium pseudotuberculosis. This highly contagious pathogen leads to significant economic losses in the livestock industry due to loss of productivity, rejection of carcasses, and increased veterinary costs. CLA is characterised by the formation of abscesses in lymph nodes and internal organs. Rupture of these nodes can lead to additional contamination of the environment and further transmission. Diagnosis of CLA involves clinical examination, bacterial cultures, serological testing, and advanced molecular techniques for more accurate detection. Treatment options are limited and often ineffective as the pathogen can survive in abscesses and evade the host's immune response. Antibiotic therapy can provide temporary relief but does not eliminate infection, emphasising the importance of prevention measures. Control strategies focus on biosecurity, culling infected animals, and vaccination. While currently available vaccines reduce the incidence and severity of the disease, they do not provide complete immunity and need to be further improved. Understanding the virulence mechanisms of the pathogen and the interactions between the host and pathogen is crucial for the development of more effective vaccines and therapeutic approaches. Ongoing research and new ideas are crucial to reduce the impact of CLA on animal health and the farm economy. This emphasises the need for comprehensive management strategies, including strict hygiene measures, regular checks, and targeted vaccination plans. In addition, due to its zoonotic potential, C. pseudotuberculosis can contaminate meat and milk from infected animals, posing a risk to consumers. The ability of the pathogen to infect both animals and humans emphasises the importance of research into its prevention and diagnosis.
Evolución de la estrategia ambiental y climática de China para la Nueva Era Global: neutralidad de carbono para 2060
Authors:   Universidad Nacional de La Plata, Schulz Sebastián
Published: October 2024

En septiembre de 2020, Xi Jinping anunció el compromiso de China por alcanzar el máximo de emisiones de carbono para antes de 2030 y la neutralidad de carbono para 2060. El presente trabajo se propone analizar los objetivos y alcances de estos anuncios, centrándonos no solo en la intención de China de presentarse como un líder global en materia ambiental, sino también como portavoz de los países emergentes y en desarrollo. A su vez, se enmarcará este anuncio como la continuidad de una política estatal en materia medioambiental llevada adelante a partir de la década de los 90, en sintonía con el ascenso del protagonismo internacional de China. Para ello, se recurrirá a documentos y fuentes oficiales, y se contrastará con la literatura sobre la temática. Finalmente, se plantea que el objetivo anunciado puede lograrse, pero bajo ciertas condiciones específicas.
Framework of Family Business Process Reengineering Success and Failure Factors
Authors: Alnahdi Saleh Mobarak , Alqahtani Ammar .
Published: October 2024

The study aimed to build a family framework to re-engineer family businesses’ success and failure processes in the Kingdom of Saudi Arabia. Documentary methods are the techniques used to categorize, investigate, interpret and identify the limitations of physical sources, most commonly written documents, whether in the private or public domain (personal papers, commercial records, state archives, communications, or legislation). The data that will be examined is the data for the period 2021-2022. The data was obtained through observations and documentation. The study revealed that family businesses in the Kingdom of Saudi Arabia need to be restructured to keep pace with the Kingdom’s vision 2030 and the requirements of the local and international capital markets for achieving tangible success in the business sector in Saudi Arabia.