bluuebunny/crossref_metadata_2025 huggingface dataset:
Financial stability and local economic development: the experience of Italian labour market areas
Authors: Barra Cristian , Zotti Roberto
Published: May 2021

Regulators should ensure the smooth functioning of the system and promote regional development. Making the health of financial institutions is therefore a prerequisite for a sustainable economic development. This paper contributes to the literature on the relationship between the financial stability and growth within the area of one country. This implies that institutional, legal, and cultural factors are more adequately controlled for and financial markets are more accurately bounded. Using a rich sample of Italian banks over the 2001–2012 period, this paper addresses whether different measures of financial distress affect economic development of labour market areas in Italy. Results show that the financial stability has a positive effect on local economic development, robust to alternative variables capturing financial vulnerability. The presence of spatial effects is tested showing that better financial conditions of the banking system in neighbouring areas have a detrimental effect on an area’s growth.
Investigation of different dietary-fibre-ingredients for the design of a fibre enriched bread formulation low in FODMAPs based on wheat starch and vital gluten
Authors: Atzler Jonas J. , Sahin Aylin W. , Gallagher Eimear , Zannini Emanuele , Arendt Elke K.
Published: May 2021

Consumption of fermentable oligo-, di-, monosaccharides and polyols (FODMAPs) often induces symptoms of irritable bowel syndrome (IBS). Since FODMAPs and dietary fibre (DF) share certain characteristics, IBS-patients have a limited intake of DF. Therefore, enrichment of a low FODMAP model bread (based on 84% wheat starch and 16% vital gluten) with various fibres (bamboo, cellulose, psyllium, guar gum) in two different concentrations (3 g/100 g and 6 g/100 g) was investigated. Physico-chemical properties of doughs and breads were analysed (fermentation quality, gluten development, specific volume and hardness), as well as the release of reducing sugars during in vitro digestion. High performance anion exchange chromatography with coupled pulsed amperometric detection (HPAEC-PAD) was used to determine the FODMAP levels (contents of mannitol, sorbitol, fructose in excess of glucose, fructans and α-galactooligosaccharides) of both dough and bread. Prototypes were compared with wheat flour-based breads (bakers’ flour with and without wheat bran addition) to assess the performance of these prototypes. Prototypes showed a decreased quality compared to a baker’s flour control, however, a quality comparable to commercial wheat bran breads was found. This in combination with a lower release of reducing sugars during in vitro digestion underline the potential of fibre enriched breads as part of a healthier and more palateable low FODMAP diet. Furthermore, this study highlights the importance of the type (viscous and insoluble) and the concentration of fibres used. Application of psyllium in a concentration of 3 g/100 g showed the most beneficial impact on both physical (specific volume, hardness after 0 h and 24 h) and nutritional aspects of bread.
Prevalence of pathological FFRCT values without coronary artery stenosis in an asymptomatic marathon runner cohort
Authors: Gassenmaier Sebastian , Tsiflikas Ilias , Greulich Simon , Kuebler Jens , Hagen Florian , Nikolaou Konstantin , Niess Andreas M. , Burgstahler Christof , Krumm Patrick
Published: May 2021

Objectives

To evaluate computed tomography fractional flow reserve (FFRCT) values in distal parts of the coronaries in an asymptomatic cohort of marathon runners without any coronary stenosis for potentially false-positive values.

Methods

Ninety-eight asymptomatic male marathon runners (age 53 ± 7 years) were enrolled in a prospective monocentric study and underwent coronary computed tomography angiography (CCTA). CCTA data were analyzed for visual coronary artery stenosis. FFRCT was evaluated in 59 participants without coronary artery stenosis in proximal, mid, and distal coronary sections using an on-site software prototype.

Results

In participants without coronary artery stenosis, abnormal FFRCT values ≤ 0.8 in distal segments were found in 22 participants (37%); in 19 participants in the LAD; in 5 participants in the LCX; and in 4 participants in the RCA. Vessel diameters in participants with FFRCT values > 0.80 compared to ≤ 0.80 were 1.6 ± 0.3 mm versus 1.5 ± 0.3 mm for distal LAD (p = 0.025), 1.8 ± 0.3 mm versus 1.6 ± 0.5 mm for distal LCX (p = 0.183), and 2.0 ± 0.4 mm versus 1.5 ± 0.2 mm for distal RCA (p < 0.001).

Conclusions

Abnormal FFRCT values of ≤ 0.8 frequently occurred in distal coronary segments in subjects without any anatomical coronary artery stenosis. This effect is only to some degree explainable by small distal vessel diameters. Therefore, the validity of hemodynamic relevance evaluation using FFRCT in distal coronary artery segment stenosis is reduced.

Key Points

• Abnormal FFRCT values (≤ 0.8) occurred in over a third of the subjects in the distal LAD despite the absence of coronary artery stenosis..

• Therefore, the validity of hemodynamic relevance evaluation in distal coronary artery segment stenosis is reduced.

• Decision-making based on abnormal FFRCT values in distal vessel sections should be performed with caution and only in combination with visual assessment of the grade of stenosis..
Sex-specific differences and long-term outcome of patients with coronary artery disease and chronic kidney disease: the Coronary Artery Disease and Renal Failure (CAD-REF) Registry
Authors: Engelbertz Christiane , Pinnschmidt Hans O. , Freisinger Eva , Reinecke Holger , Schmitz Boris , Fobker Manfred , Schmieder Roland E. , Wegscheider Karl , Breithardt Günter , Pavenstädt Hermann , Brand Eva
Published: May 2021

Background

Cardiovascular morbidity and mortality are closely linked to chronic kidney disease (CKD). Sex-specific long-term outcome data of patients with coronary artery disease (CAD) and CKD are scarce.

Methods

In the prospective observational multicenter Coronary Artery Disease and REnal F﻿ailure (CAD-REF) Registry, 773 (23.1%) women and 2,579 (76.9%) men with angiographically documented CAD and different stages of CKD were consecutively enrolled and followed for up to 8 years. Long-term outcome was evaluated using survival analysis and multivariable Cox-regression models.

Results

At enrollment, women were significantly older than men, and suffered from more comorbidities like CKD, hypertension, diabetes mellitus, and multivessel coronary disease. Regarding long-term mortality, no sex-specific differences were observed (Kaplan–Meier survival estimates: 69% in women vs. 69% in men, plog-rank = 0.7). Survival rates decreased from 89% for patients without CKD at enrollment to 72% for patients with CKD stages 1–2 at enrollment and 49% for patients with CKD stages 3–5 at enrollment (plog-rank < 0.001). Cox-regression analysis revealed that sex or multivessel coronary disease were no independent predictors of long-term mortality, while age, CKD stages 3–5, albumin/creatinine ratio, diabetes, valvular heart disease, peripheral artery disease, and left-ventricular ejection fraction were predictors of long-term mortality.

Conclusions

Sex differences in CAD patients mainly exist in the cardiovascular risk profile and the extent of CAD. Long-term mortality was not depended on sex or multivessel disease. More attention should be given to treatment of comorbidities such as CKD and peripheral artery disease being independent predictors of death.

Clinical Trail Registration ClinicalTrials.gov Identifier: NCT00679419

Graphic abstract
Mutations in MT-ATP6 are a frequent cause of adult-onset spinocerebellar ataxia
Authors: Nolte Dagmar , Kang Jun-Suk , Hofmann Amrei , Schwaab Eva , Krämer Heidrun H. , Müller Ulrich
Published: May 2021

Adult-onset ataxias are a genetically and clinically heterogeneous group of movement disorders. In addition to nuclear gene mutations, sequence changes have also been described in the mitochondrial genome. Here, we present findings of mutation analysis of the mitochondrial gene MT-ATP6. We analyzed 94 patients with adult-onset spinocerebellar ataxia (SCA), including 34 sporadic cases. In all patients, common sequence changes found in SCAs such as repeat expansions and point mutations had been excluded previously. We found pathogenic MT-ATP variants in five of these patients (5.32%), two of whom were sporadic. Four of the five mutations have not previously been described in ataxias. All but one of these mutations affect transmembrane helices of subunit-α of ATP synthase. Two mutations (p.G16S, and p.P18S) disrupt transmembrane helix 1 (TMH1), one mutation (p.G167D) affects TMH5, and another one (p.L217P) TMH6. The fifth mutation (p.T96A) describes an amino acid change in close proximity to transmembrane helix 3 (TMH3). The level of heteroplasmy was either complete or very high ranging from 87 to 99%. The high prevalence of pathogenic MT-ATP6 variants suggests that analysis of this gene should be included in the routine workup of both hereditary and sporadic ataxias.
Numerical effectiveness investigation of the automatic ball balancer with a deep chamber
Authors: Pakuła Sebastian
Published: May 2021

The article describes the simulation results of an unbalanced rotary machine with an automatic ball balancer with a deep chamber (ABB-DC) based on a mathematical model of such a system. The ABB chamber has a cylindrical shape and is filled with balls that can move freely in general motion. The model takes into account mutual collisions between the balls, as well as between the balls and the chamber. The model also includes friction forces and rolling resistance. The comparison of simulation results performed with two different construction types of the chamber, classic single-layer drum (ABB-SC) and ABB-DC, confirmed the better efficiency of the ABB-DC in the optimal range of the number of balls. The machine body movement was limited to planar motion. The correctness of such a limitation has been verified by analyzing waveforms of reaction forces of constraints and their moments. Waveforms were divided into transient and steady states. The results of the analysis indicate the additional constraints do not significantly affect machine body movements. However, this might affect the ball arranging process in the ABB chamber. The paper also presents details of performing numerical simulations based on the developed mathematical model and numerical tests to determine the optimal integration time-step.
Comparative analysis of the fragility curves for Italian residential masonry and RC buildings
Authors: da Porto Francesca , Donà Marco , Rosti Annalisa , Rota Maria , Lagomarsino Sergio , Cattari Serena , Borzi Barbara , Onida Mauro , De Gregorio Daniela , Perelli Francesca Linda , Del Gaudio Carlo , Ricci Paolo , Speranza Elena
Published: May 2021

The Department of Civil Protection (DPC), in compliance with the EU decision 1313/2013 and at the request of the Sendai Framework for Disaster Risk Reduction 2015–2030 to update the disaster risk assessments by various countries, released the latest National Risk Assessment for Italy at the end of 2018. Specifically, as regards the seismic risk assessment, six research units belonging to two centres of competence of the DPC collaborated under its guidance to update the risk maps of the Italian residential heritage. This extensive collaboration complied with the recent Italian code for Civil Protection, which requires a broad scientific consensus for risk assessment. During this research activity, six fragility models were developed, according to some common criteria (four for masonry buildings and two for RC buildings). These models were then implemented by the DPC for the definition of the national seismic risk. Within this context, the aim of this paper is to evaluate the risk results provided by these models, compare their features, and assess and validate their prediction capabilities. In particular, this paper shows the comparison of predicted and observed damage scenarios and consequences on building stock and the population of two seismic events, i.e. L’Aquila 2009 and Amatrice 2016. Furthermore, the paper provides some interesting damage and risk predictions at a national level. Overall, the forecasts and comparisons made in this study demonstrate the validity of the approach adopted by the DPC for the assessment of national seismic risk.
Assessment of water contamination by potentially toxic elements in mangrove lagoons of the Red Sea, Saudi Arabia
Authors: Alamri Dhafer Ali , Al-Solaimani Samir G. , Abohassan Refaat A. , Rinklebe Jörg , Shaheen Sabry M.
Published: May 2021

Mangrove (Avicennia marina) forests in the Red Sea cost have great concern from environmental, biological, economic, and social points of view. Therefore, assessing water contamination in this ecosystem is worth to be investigated. Consequently, here we aimed to examine the levels of salinity, acidity, and the total content of Fe, Mn, Cu, Zn, Cd, Cr, Ni, and Pb in water samples collected from the upper, middle, and lower part of three mangrove lagoons (i.e., Al-Shuaiba, Yanbu, and Jeddah), Red Sea, Saudi Arabia. The total metal content (µg L−1) in water samples differed significantly among the studied areas and ranged from 286.2 to 4815.0 for Fe, 86.4–483.0 for Mn, 22.9–468.8 for Cu, 199.2–366.6 for Zn, 44.1–99.8 for Cd, 25.6–80.3 for Cr, 11.6–41.5 for Ni, and from 17.7 to 102.0 for Pb. The mean values of Cu, Zn, Cd, and Pb were higher than the WHO water quality standards for fisheries. Water samples in Yanbu were more contaminated and contained higher concentrations of all metals than Jeddah and Al-Shuaiba, due to the petrochemical industries in this industrial area. Our findings suggest that the high metal content in the water of these mangrove sites, particularly in Yanbu, should be considered due to the high potential environmental and human health risks in these ecosystems. These results may help for demonstrating effective approaches for the management of these lagoons. More studies will be carried out on the sediment and mangrove plants in this ecosystem.
The far-infrared spectroscopic surveyor (FIRSS)
Authors: Rigopoulou D. , Pearson C. , Ellison B. , Wiedner M. , Okada V. Ossenkopf , Tan B. K. , Garcia-Bernete I. , Gerin M. , Yassin G. , Caux E. , Molinari S. , Goicoechea J. R. , Savini G. , Hunt L. K. , Lis D. C. , Goldsmith P. F. , Aalto S. , Magdis G. , Kramer C.
Published: May 2021

We are standing at the crossroads of powerful new facilities emerging in the next decade on the ground and in space like ELT, SKA, JWST, and Athena. Turning the narrative of the star formation potential of galaxies into a quantitative theory will provide answers to many outstanding questions in astrophysics, from the formation of planets to the evolution of galaxies and the origin of heavy elements. To achieve this goal, there is an urgent need for a dedicated space-borne, far-infrared spectroscopic facility capable of delivering, for the first time, large scale, high spectral resolution (velocity resolved) multiwavelength studies of the chemistry and dynamics of the ISM of our own Milky Way and nearby galaxies. The Far Infrared Spectroscopic Surveyor (FIRSS) fulfills these requirements and by exploiting the legacy of recent photometric surveys it seizes the opportunity to shed light on the fundamental building processes of our Universe.
Exoplanet mass estimation for a sample of targets for the Ariel mission
Authors: Barnes J. R. , Haswell C. A.
Published: May 2021

Ariel’s ambitious goal to survey a quarter of known exoplanets will transform our knowledge of planetary atmospheres. Masses measured directly with the radial velocity technique are essential for well determined planetary bulk properties. Radial velocity masses will provide important checks of masses derived from atmospheric fits or alternatively can be treated as a fixed input parameter to reduce possible degeneracies in atmospheric retrievals. We quantify the impact of stellar activity on planet mass recovery for the Ariel mission sample using Sun-like spot models scaled for active stars combined with other noise sources. Planets with necessarily well-determined ephemerides will be selected for characterisation with Ariel. With this prior requirement, we simulate the derived planet mass precision as a function of the number of observations for a prospective sample of Ariel targets. We find that quadrature sampling can significantly reduce the time commitment required for follow-up RVs, and is most effective when the planetary RV signature is larger than the RV noise. For a typical radial velocity instrument operating on a 4 m class telescope and achieving 1 m s−1 precision, between ~17% and ~ 37% of the time commitment is spent on the 7% of planets with mass Mp < 10 M⊕. In many low activity cases, the time required is limited by asteroseismic and photon noise. For low mass or faint systems, we can recover masses with the same precision up to ~3 times more quickly with an instrumental precision of ~10 cm s−1.
Multi-Wavelength Densitometer for Experimental Research on the Optical Characteristics of Smoke Layers
Authors: Węgrzyński Wojciech , Antosiewicz Piotr , Fangrat Jadwiga
Published: May 2021

A novel multi-wavelength densitometer was built for the purpose of continuous and simultaneous measurements of light obscuration in smoke layers, concurrently in five bands (λ = 450 nm, 520 nm, 658 nm, 830 nm and 980 nm). This device was used for determining transmittance and visibility in smoke parameters of a smoke layer from the fire of 1.00 dm3 of n-Heptane in a 0.33 × 0.33 m tray located in a test chamber (9.60 × 9.80 × 4.00 m3). The performance of the device was compared with a commercial Lorenz densitometer at 880 nm. Significant differences in measured value of transmittance were observed between the different sensors – from 65% at 450 nm (blue light), 80% at 658 nm (red light) to 95% at 980 nm (IR). The visibility in smoke, estimated following the theory of Jin for light reflecting signs (K = 3), ranged from 7.5 m (blue light) to 12 m (red light) and for the light-emitting (K = 8) signs from 18 to 32 m, respectively. The performed experiment has confirmed the applicability and added value of multi-wavelength measurements of light-extinction in fire experiments. The device was sensitive to temperature variations and requires active cooling and careful warm-up prior to experiments, to reach the expected sensitivity.
Symplectic Quantization I: Dynamics of Quantum Fluctuations in a Relativistic Field Theory
Authors: Gradenigo Giacomo , Livi Roberto
Published: May 2021

We propose here a new symplectic quantization scheme, where quantum fluctuations of a scalar field theory stem from two main assumptions: relativistic invariance and equiprobability of the field configurations with identical value of the action. In this approach the fictitious time of stochastic quantization becomes a genuine additional time variable, with respect to the coordinate time of relativity. Thisintrinsic timeis associated to a symplectic evolution in the action space, which allows one to investigate not only asymptotic, i.e. equilibrium, properties of the theory, but also its non-equilibrium transient evolution. In this paper, which is the first one in a series of two, we introduce a formalism which will be applied to general relativity in its companion work (Gradenigo, Symplectic quantization II: dynamics of space-time quantum fluctuations and the cosmological constant, 2021).
Reducing Library Characterization Time for Cell-aware Test while Maintaining Test Quality
Authors: Gao Zhan , Hu Min-Chun , Malagi Santosh , Swenton Joe , Huisken Jos , Goossens Kees , Marinissen Erik Jan
Published: May 2021

Cell-aware test (CAT) explicitly targets faults caused by defects inside library cells to improve test quality, compared with conventional automatic test pattern generation (ATPG) approaches, which target faults only at the boundaries of library cells. The CAT methodology consists of two stages. Stage 1, based on dedicated analog simulation, library characterization per cell identifies which cell-level test pattern detects which cell-internal defect; this detection information is encoded in a defect detection matrix (DDM). In Stage 2, with the DDMs as inputs, cell-aware ATPG generates chip-level test patterns per circuit design that is build up of interconnected instances of library cells. This paper focuses on Stage 1, library characterization, as both test quality and cost are determined by the set of cell-internal defects identified and simulated in the CAT tool flow. With the aim to achieve the best test quality, we first propose an approach to identify a comprehensive set, referred to as full set, of potential open- and short-defect locations based on cell layout. However, the full set of defects can be large even for a single cell, making the time cost of the defect simulation in Stage 1 unaffordable. Subsequently, to reduce the simulation time, we collapse the full set to a compact set of defects which serves as input of the defect simulation. The full set is stored for the diagnosis and failure analysis. With inspecting the simulation results, we propose a method to verify the test quality based on the compact set of defects and, if necessary, to compensate the test quality to the same level as that based on the full set of defects. For 351 combinational library cells in Cadence’s GPDK045 45nm library, we simulate only 5.4% defects from the full set to achieve the same test quality based on the full set of defects. In total, the simulation time, via linear extrapolation per cell, would be reduced by 96.4% compared with the time based on the full set of defects.
Performing Expertise in Building Regulation: ‘Codespeak’ and Fire Safety Experts
Authors: Law Angus , Spinardi Graham
Published: May 2021

Fire safety expertise was in great demand following the Grenfell Tower fire in London in June 2017. The government established a review of building regulations and an expert panel to inform its responses to Grenfell, and many other relevant organisations also formed their own expert panels. However, expert knowledge in fire safety is a highly contested domain, with knowledge claims based on differing sources. Fire fighters can claim expertise based on their experience of fighting fires, scientists and science-based engineers can claim expertise from experimentation, and those who create and enact regulations can claim expertise in what can termed ’codespeak’—the language of regulation. Although distanced from fundamental empirical experience of fire, codespeak is powerful because of its relative clarity and certainty, and legal status. Building users also bring their own form of ‘local’ expertise—they have first-hand experience of the practicalities of the solutions wrought by the other experts. Policy-makers thus face many competing forms of expert advice on fire safety, and their ability to judge what is most relevant in any particular case rests on the existence of a sufficient range and depth of in-house government expertise.
Better state pictures facilitating state machine characteristic conjecture
Authors: Bui Dang Duy , Ogata Kazuhiro
Published: May 2021

The mutual exclusion protocol invented by Mellor-Crummey and Scott (called MCS protocol) is used to exemplify that state picture designs based on which the state machine graphical animation (SMGA) tool produces graphical animations should be better visualized. Variants of MCS protocol have been used in Java virtual machines and therefore the 2006 Edsger W. Dijkstra Prize in Distributed Computing went to their paper on MCS protocol. The new state picture design of a state machine formalizing MCS protocol is assessed based on Gestalt principles, more specifically proximity principle and similarity principle. We report on a core part of a formal verification case study in which the new state picture design and the SMGA tool largely contributed to the successful completion of the formal proof that MCS protocol enjoys the mutual exclusion property. The lessons learned acquired through our experiments are summarized as two groups of tips. The first group is some new tips on how to make state picture designs. The second one is some tips on how to conjecture state machine characteristics by using the SMGA tool. We also report on one more case study in which the state picture design has been made for the mutual exclusion protocol invented by Anderson (called Anderson protocol) and some characteristics of the protocol have been discovered based on the tips.
Learning-based nonlinear model predictive control with accurate uncertainty compensation
Authors: Xie Jingjie , Zhao Xiaowei , Dong Hongyang
Published: May 2021

A learning-based nonlinear model predictive control (LBNMPC) method is proposed in this paper for general nonlinear systems under system uncertainties and subject to state and input constraints. The proposed LBNMPC strategy decouples the robustness and performance requirements by employing an additional learned model and introducing it into the MPC framework along with the nominal model. The nominal model helps to ensure the closed-loop system’s safety and stability, and the learned model aims to improve the tracking behaviors. As a core of the learned model construction, an online parameter estimator is designed to deal with system uncertainties. This estimation process effectively evaluates both the current and historical effects of uncertainties, leading to superior estimating performance compared with conventional methods. By constructing an invariant terminal constraint set, we prove that the LBNMPC is recursively feasible and robustly asymptotically stable. Numerical verifications for a two-link manipulator are conducted to validate the effectiveness and robustness of the proposed control scheme.
Association Between Conflicts of Interest and Authors’ Positions on Harms of Varenicline: a Cross-Sectional Analysis
Authors: Fabbri Alice , Nejstgaard Camilla Hansen , Grundy Quinn , Bero Lisa , Dunn Adam G. , Mohammad Annim , Mintzes Barbara
Published: May 2021

Background

Few studies have investigated the relationship between industry funding/conflicts of interest and authors’ positions in opinion pieces on drug safety. Harmful effects of varenicline, a treatment for smoking cessation, have been highly contested.

Objective

To examine the association between pharmaceutical industry funding/authors’ financial conflicts of interest and position on varenicline in opinion articles, especially in relation to the minimization of harms; to assess whether opinion pieces on drug safety issues written by authors with conflicts of interest are more frequently cited in the news or social media.

Design

Cross-sectional analysis.

Participants

English language opinion pieces and narrative reviews about varenicline published between May 2006 and February 2019.

Main Measures

Odds ratios and 95% confidence intervals; the Mann-Whitney two-sample statistic was used to test for differences in Altmetric scores, a measure of media attention.

Key Results

Of the 221 included articles, 30.3% (67) disclosed the funding source and 62.9% (139) disclosed authors’ conflicts of interest. Authors of opinion pieces on varenicline who reported financial ties to the pharmaceutical industry (as a conflict of interest or funding source) were more likely to minimise the cardiovascular and psychiatric risk of varenicline compared to those without conflicts of interest or industry funding (OR: 4.00; 95% CI: 1.32 to 12.16 for cardiovascular risk; OR: 8.51; 95% CI: 3.79 to 19.11 for psychiatric risk). These associations persisted in sensitivity analyses. No statistically significant difference in Altmetric score was found between articles with (mean 15.83, median 3) and without (mean 11.90, median 1) conflicts of interest, indicating similar media attention (p-value=0.11).

Conclusions

We found that authors with financial ties to drug companies were more likely to publish opinion pieces that minimised harms of varenicline. These results raise questions about journals’ editorial policies to accept reviews of treatments from authors with financial relationships with manufacturers.
Theoretical approaches to teachers’ lesson designs involving the adaptation of mathematics textbooks: two cases from kyouzai kenkyuu in Japan
Authors: Shinno Yusuke , Mizoguchi Tatsuya
Published: May 2021

In this paper, we explore theoretical approaches to Japanese teachers’ lesson designs involving the adaptation of mathematics textbooks for instructional change. In Japan, although most teachers use textbooks as the main resource for lesson planning, calledkyouzai kenkyuu,the ways in which they use textbooks can differ. In akyouzai kenkyuupractice, Japanese teachers sometimes attempt to design innovative tasks and/or learning trajectories beyond or parallel to the textbooks and curriculum guidelines. Such practice is often invisible to international researchers, since it is culturally situated in the local context. To make it more visible, in this study we address and advance theoretical approaches using two frameworks which are well-established for research in mathematics education, namely, Anthropological Theory of the Didactic (ATD) and Documentational Approach to Didactics (DAD). Two cases of lesson design regarding fractions using the same textbook chapter for 3rd graders in primary schools in Japan, are used as examples to illustrate crucial elements of each framework and ways of combining and coordinating both frameworks. As a result, we conceptualise teachers’kyouzai kenkyuupractice using two approaches: from a praxeological analysis based on ATD, the difference in teachers’ mathematical and didactic knowledge was emphasised, while within DAD, the difference in the instrumentalisation process was emphasised. This analysis implies that the two theoretical approaches can be compatible, and used to gain deeper insight into the relationship between lesson design using the textbook and teacher knowledge.
Complex-Valued (p, q)-Harmonic Morphisms from Riemannian Manifolds
Authors: Ghandour Elsa , Gudmundsson Sigmundur
Published: May 2021

We introduce the natural notion of (p, q)-harmonic morphisms between Riemannian manifolds. This unifies several theories that have been studied during the last decades. We then study the special case when the maps involved are complex-valued. For these we find a characterisation and provide new non-trivial examples in important cases.
Fast and efficient removal of caffeine from water using dielectric barrier discharge
Authors: Al Bratty Mohammed , Al-Rajab Abdul Jabbar , Rehman Zia ur , Sharma Mukul , Alhazmi Hassan A. , Najmi Asim , Muzafar Hisham M. A. , Javed Sadique A.
Published: May 2021

Caffeine is a well-known central nervous system stimulant, which can cause anxiety, insomnia and nervousness. Domestic wastes of caffeinated drinks, beverages and chocolates are the major sources for entry of caffeine in the environmental system. Caffeine has been widely detected in natural water resources. The current study describes a method for efficient removal of caffeine from aqueous solution by a laboratory scale dielectric barrier discharge (DBD) in open air. Caffeine concentrations in various sample solutions were monitored by high-performance liquid chromatography, and the degradation products were identified by directly injecting the sample to mass spectrometer. The consequences of varied parameters such as input power, initial concentration and initial pH of the solution on the degradation of caffeine were investigated. Removal efficiency of caffeine from aqueous solution was 72.6% and 96.6% for the initial concentrations of 100 and 1 µg/mL, respectively, at initial pH 7 after 4 min treatment in DBD plasma system with 60 W input powers. Caffeine removal efficiency was less in acidic solutions (initial pH 4), and insignificant degradation was observed in alkaline solutions (initial pH 10). Furthermore, the degradation of caffeine was also enhanced by increasing the input power in DBD system. The DBD system used in this study has been considered to be fast, effective and economical. It was operated at atmospheric condition in open air without using catalyst, expensive gases or organic solvents, and significant degradation of caffeine was achieved in a short (4 min) treatment time.
Forecast Hesitancy: Why are People Reluctant to Believe, Accept, or Respond to Various Weather, Water, and Climate Hazard-Related Forecasts?
Authors: Glantz Michael H. , Pierce Gregory E.
Published: May 2021

Current discussions of the social phenomenon of “vaccine hesitancy” with regard to Covid-19 provide an opportunity to use hesitancy as a means to shift thinking about untimely and delayed responses to forecasts of hydrometeorological hazards. Hesitancy, that is, provides a paradigm through which such regrettably delayed responses to hydromet hazards might be better understood and effectively addressed. Without exaggeration, just about every hydromet event provides an example of how hesitancy hinders individual, community, and national government risk-reducing preventive and mitigative responses to forecasts of foreseeable, relatively near-term climate, water, or weather hazards. Reasons for such hesitancy (for vaccine and forecast use alike) include—among others—lack of trust in the science, lack of confidence in government, and persistent concern about the uncertainties that surround forecasting—both meteorological and public health. As such, a better understanding of the causes that lead to individual and group hesitancy can better inform hydromet forecasters and affected communities about ways in which beneficial actions in response to timely forecasts are often delayed. This better understanding will facilitate, where necessary, targeted interventions to enhance the societal value of forecasting by reducing this long-observed challenge of “forecast hesitancy.” First, this article focuses on incidents of “vaccine hesitancy” that, for various reasons, people around the world are even now experiencing with regard to several now-available, and confirmed efficacious, Covid-19 vaccines. Reports of such incidents of indecisiveness first increased dramatically over the first few months of 2021, despite the strong scientific confidence that vaccination would significantly lower personal risk of contracting as well as spreading the virus. After, the notion of forecast hesitancy with regard to hydrometeorological hazards is discussed.

It’s not what you say, it’s what people hear.

-Frank Luntz (2007)
Comparison of clinical features and outcomes in COVID-19 and influenza pneumonia patients requiring intensive care unit admission
Authors: Oliva A. , Ceccarelli G. , Borrazzo C. , Ridolfi M. , D.’Ettorre G. , Alessandri F. , Ruberto F. , Pugliese F. , Raponi G. M. , Russo A. , Falletta A. , Mastroianni C. M. , Venditti M.
Published: May 2021

Background

Little is known in distinguishing clinical features and outcomes between coronavirus disease-19 (COVID-19) and influenza (FLU).

Materials/methods

Retrospective, single-centre study including patients with COVID-19 or FLU pneumonia admitted to the Intensive care Unit (ICU) of Policlinico Umberto I (Rome). Aims were: (1) to assess clinical features and differences of patients with COVID-19 and FLU, (2) to identify clinical and/or laboratory factors associated with FLU or COVID-19 and (3) to evaluate 30-day mortality, bacterial superinfections, thrombotic events and invasive pulmonary aspergillosis (IPA) in patients with FLU versus COVID-19.

Results

Overall, 74 patients were included (19, 25.7%, FLU and 55, 74.3%, COVID-19), median age 67 years (58–76). COVID-19 patients were more male (p = 0.013), with a lower percentage of COPD (Chronic Obstructive Pulmonary Disease) and chronic kidney disease (CKD) (p = 0.001 and p = 0.037, respectively) than FLU. SOFA score was higher (p = 0.020) and lymphocytes were significantly lower in FLU than in COVID-19 [395.5 vs 770.0 cells/mmc, p = 0.005]. At multivariable analysis, male sex (OR 6.1, p < 0.002), age > 65 years (OR 2.4, p = 0.024) and lymphocyte count > 725 cells/mmc at ICU admission (OR 5.1, p = 0.024) were significantly associated with COVID-19, whereas CKD and COPD were associated with FLU (OR 0.1 and OR 0.16, p = 0.020 and p < 0.001, respectively). No differences in mortality, bacterial superinfections and thrombotic events were observed, whereas IPA was mostly associated with FLU (31.5% vs 3.6%, p = 0.0029).

Conclusions

In critically ill patients, male sex, age > 65 years and lymphocytes > 725 cells/mmc are related to COVID-19. FLU is associated with a significantly higher risk of IPA than COVID-19.
Geometrical nonlinearities and shape effects in electromechanical models of piezoelectric bridge structures
Authors: Ohlsson Fredrik , Johannisson Pontus , Rusu Cristina
Published: May 2021

We consider nonlinear shape effects appearing in the lumped electromechanical model of a bimorph piezoelectric bridge structure due to the interaction between the electromechanical constitutive model and the geometry of the structure. At finite proof-mass displacement and electrode voltage, the shape of the beams is no longer given by Euler-Bernoulli theory which implies that shape effects enter in both the electrical and mechanical domains and in the coupling between them. Accounting for such effects is important for the accurate modelling of, e.g., piezoelectrical energy harvesters and actuators in the regime of large deflections and voltages. We present a general method, based on a variational approach minimizing the Gibbs enthalpy of the system, for computing corrections to the nominal shape function and the associated corrections to the lumped model. The lowest order correction is derived explicitly and is shown to produce significant improvements in model accuracy, both in terms of the Gibbs enthalpy and the shape function itself, over a large range of displacements and voltages. Furthermore, we validate the theoretical model using large deflection finite element simulations of the bridge structure and conclude that the lowest order correction substantially improve the model, obtaining a level of accuracy expected to be sufficient for most applications. Finally, we derive the equations of motion for the lowest order corrected model and show how the coupling between the electromechanical properties and the geometry of the bridge structure introduces nonlinear interaction terms.
SIM boxing – why mobile regulators need to act now
Authors: Gent Andy
Published: May 2021

Mobile operators lose more than $28bn a year to telecoms fraud and revenue loss, according to the Communications Fraud Control Association (CFCA). In an industry where margins are increasingly being squeezed, fraud represents the single biggest preventable revenue threat to mobile operators, and in some regions SIM boxing is a significant contributor to the problem.

Fraud represents the single biggest preventable revenue threat to mobile operators, and in some regions SIM boxing is a significant contributor to the problem.

SIM box or bypass fraud takes place when individuals or organisations buy thousands of SIM cards to unlawfully terminate calls. A multi-layered approach, using intelligent technology solutions combined with tighter control over SIM card sales, and penalties for poor fraud management performance, are new weapons in network regulators' armoury in the fight against criminals, says Andy Gent of Revector.
Are we losing the fight against cybercrime?
Authors: Delcher Pierre
Published: May 2021

Cyber security researchers, governmental bodies, independent threat hunters, private cyber security organisations – we all do our jobs as part of a broader mission of building a safer world. Yet, somehow, we are failing.
(Mis)Informed: What Americans Know About Social Groups and Why it Matters for Politics
Authors: Abrajano Marisa , Lajevardi Nazita
Published: May 2021

This Element examines just how much the public knows about some of America's most stigmatized social groups, who comprise 40.3% of the population, and evaluates whether misinformation matters for shaping policy attitudes and candidate support. The authors design and field an original survey containing large national samples of Black, Latino, Asian, Muslim, and White Americans, and include measures of misinformation designed to assess the amount of factual information that individuals possess about these groups. They find that Republicans, Whites, the most racially resentful, and consumers of conservative news outlets are the most likely to be misinformed about socially marginalized groups. Their analysis also indicates that misinformation predicts hostile policy support on racialized issues; it is also positively correlated with support for Trump. They then conducted three studies aimed at correcting misinformation. Their research speaks to the prospects of a well-functioning democracy, and its ramifications on the most marginalized.
High-power non-perturbative laser delivery diagnostics at the final focus of 100-TW-class laser pulses
Authors: Isono Fumika , van Tilborg Jeroen , Barber Samuel K. , Natal Joseph , Berger Curtis , Tsai Hai-En , Ostermayr Tobias , Gonsalves Anthony , Geddes Cameron , Esarey Eric
Published: May 2021

Controlling the delivery of multi-terawatt and petawatt laser pulses to final focus, both in position and angle, is critical to many laser applications such as optical guiding, laser–plasma acceleration, and laser-produced secondary radiation. We present an online, non-destructive laser diagnostic, capable of measuring the transverse position and pointing angle at focus. The diagnostic is based on a unique double-surface-coated wedged-mirror design for the final steering optic in the laser line, producing a witness beam highly correlated with the main beam. By propagating low-power kilohertz pulses to focus, we observed spectra of focus position and pointing angle fluctuations dominated by frequencies below 70 Hz. The setup was also used to characterize the excellent position and pointing angle correlation of the 1 Hz high-power laser pulses to this low-power kilohertz pulse train, opening a promising path to fast non-perturbative feedback concepts even on few-hertz-class high-power laser systems.
Evaluation of a continuously active disinfectant for decontamination of portable medical equipment
Authors: Redmond Sarah N. , Cadnum Jennifer L. , Silva Sandra Y. , Pearlmutter Basya S. , Jencson Annette L. , Alhmidi Heba , Wilson Brigid M. , Donskey Curtis J.
Published: May 2021

A single spray application of a continuously active disinfectant on portable equipment resulted in significant reductions in aerobic colony counts over 7 days and in recovery of Staphylococcus aureus and enterococci: 3 of 93 cultures (3%) versus 11 of 97 (11%) and 20 of 97 (21%) in quaternary ammonium disinfectant and untreated control groups, respectively.
LYRIC LOCATION AND PERFORMANCE CIRCUMSTANCES IN SAPPHO AND ALCAEUS: A COGNITIVE APPROACH
Authors: Gribble David
Published: May 2021

A striking feature of the songs of Sappho and Alcaeus is their constant use of ‘deictic’ signals (‘I’, ‘you’, ‘this’, ‘here’, ‘now’) to establish a setting in a specific location in time and space. This article examines the created worlds of Sappho and Alcaeus, drawing on cognitive methodologies, in particular Text World Theory. It argues for the importance of a methodological distinction between the circumstances of performance of the songs, and the cognitive world they create (‘discourse world’ and ‘text world’). The locations established by the songs are designed to assimilate to, or mirror, the plausible/potential circumstances of actual performance, but are distinct from them, and are just as constructed as the artful lyric locations of Horace or Thomas Gray. Close readings of the songs show how Sappho and Alcaeus use ‘location’ as a tool in their poetics, exploiting the interaction between the world created by the songs and the circumstances of their performance.
Testing carbon and nitrogen sources for thein vitrogrowth of the model lichenized fungusEndocarpon pusillumHedw.
Authors: Mead Oliver L. , Gueidan Cécile
Published: May 2021

To improve the efficiency of isolating and culturing lichen mycobionts, we performed a growth assay on an Australian strain of the soil-crust lichenized fungusEndocarpon pusillumHedw. This assay determined the preferred nitrogen and carbon sources of the fungus by limiting the available nitrogen or carbon sources to single compounds found in soils, plants and lichen thalli. We found that the non-proteinaceous amino acid, GABA, produced the most growth of all nutrients when provided as the sole nitrogen source but was a poor carbon source. Fructose, glucose, cellobiose and sorbitol produced the most growth of all the carbon sources tested. Ammonium, nitrate and polyamines were poor nutrient sources. These findings correspond with reports of primary metabolite pools in other lichen species and may guide future studies involving growth of recalcitrant lichen mycobionts.
Distribution and habitat preference of protected reindeer lichen species (Cladonia arbuscula, C. mitis and C. rangiferina) in the Balaton Uplands (Hungary)
Authors: Sinigla Mónika , Szurdoki Erzsébet , Lőkös László , Bartha Dénes , Galambos István , Bidló András , Farkas Edit
Published: May 2021

The maintenance of protected lichen species and their biodiversity in general depends on good management practices based on their distribution and habitat preferences. To date, 10 of the 17 protected lichen species of Hungary have been recorded in the Bakony Mts including the Balaton Uplands region. Habitat preferences of three protected Cladonia species (C. arbuscula, C. mitis and C. rangiferina) growing on underlying rocks of red sandstone, basalt, Pannonian sandstone and gravel were investigated by detailed sampling. We recorded aspect, underlying rock type, soil depth, pH and CaCO3 content, habitat type (as defined by the General National Habitat Classification System Á-NÉR), all species of lichen, bryophyte and vascular plants as well as percentage cover of exposed rock, total bryophytes, lichens, vascular plants and canopy, degree of disturbance and animal impacts. Sporadic populations of these species mostly exist at the top of hills and mountains in open acidofrequent oak forests, but they may occur in other habitats, such as closed acidofrequent oak forests, slope steppes on stony soils, siliceous open rocky grasslands, open sand steppes, wet and mesic pioneer scrub and dry Calluna heaths. Cladonia rangiferina was found to grow beneath higher canopy cover than either C. arbuscula or C. mitis in the Balaton Uplands. Furthermore, there were significant differences in canopy cover between occupied and unoccupied quadrats in the case of all three species. Cladonia rangiferina is a good indicator species of natural habitats in Hungary due to its restricted distribution and low ecological tolerance. These results may lead to the adoption of effective conservation methods (e.g. game exclusion, artificial dispersal) in the future.
Three new species of crustoseTeloschistaceaein Siberia and the Far East
Authors: Frolov Ivan V. , Vondrák Jan , Konoreva Liudmila A. , Chesnokov Sergey V. , Himelbrant Dmitry E. , Arup Ulf , Stepanchikova Irina S. , Prokopiev Ilya A. , Yakovchenko Lidia S. , Davydov Evgeny A.
Published: May 2021

Three species of the familyTeloschistaceae(lichenized Ascomycota) are described as new to science from Southern and Eastern Siberia and the Far East. CorticolousCaloplaca savicziibelongs to the genusCaloplacas. str.; it hasC. cerina-like apothecia and green to grey-green, crateriform soralia with a white rim.Lendemeriella aureopruinosais a saxicolous taxon with a thin grey thallus and small apothecia 0.3–0.6 mm in diameter, with a dark orange disc usually bearing epipsamma and often with a grey true exciple containing the pigment Cinereorufa-green.Orientophila infirmais a corticolous species with an endophloeodal thallus and small orange apothecia, 0.2–0.3 mm in diameter, usually with an inconspicuous thalline exciple. All new taxa presumably have a boreal north-eastern distribution in Asia.