bluuebunny/crossref_metadata_2025 huggingface dataset:
Postsynaptic Protein Shank3a Deficiency Synergizes with Alzheimer's Disease Neuropathology to Impair Cognitive Performance in the 3xTg-AD Murine Model
Authors: Landry Olivier , François Arnaud , Oye Mintsa Mi-Mba Méryl-Farelle , Traversy Marie-Therese , Tremblay Cyntia , Emond Vincent , Bennett David A. , Gylys Karen H. , Buxbaum Joseph D. , Calon Frédéric
Published: May 2023

Synaptic loss is intrinsically linked to Alzheimer's disease (AD) neuropathology and symptoms, but its direct impact on clinical symptoms remains elusive. The postsynaptic protein Shank3 (SH3 and multiple ankyrin repeat domains) is of particular interest, as the loss of a single allele of theSHANK3gene is sufficient to cause profound cognitive symptoms in children. We thus sought to determine whether a SHANK3 deficiency could contribute to the emergence or worsening of AD symptoms and neuropathology. We first found a 30%-50% postmortem loss of SHANK3a associated with cognitive decline in the parietal cortex of individuals with AD. To further probe the role of SHANK3 in AD, we crossed male and female 3xTg-AD mice modelling Aβ and tau pathologies withShank3a-deficient mice (Shank3Δex4-9). We observed synergistic deleterious effects of Shank3a deficiency and AD neuropathology on object recognition memory at 9, 12, and 18 months of age and on anxious behavior at 9 and 12 months of age in hemizygous Shank3Δex4-9-3xTg-AD mice. In addition to the expected 50% loss of Shank3a, levels of other synaptic proteins, such as PSD-95, drebrin, and homer1, remained unchanged in the parietotemporal cortex of hemizygous Shank3Δex4-9animals. However, Shank3a deficiency increased the levels of soluble Aβ42and human tau at 18 months of age compared with 3xTg-AD mice with normal Shank3 expression. The results of this study in human brain samples and in transgenic mice are consistent with the hypothesis that Shank3 deficiency makes a key contribution to cognitive impairment in AD.

SIGNIFICANCE STATEMENTAlthough the loss of several synaptic proteins has been described in Alzheimer's disease (AD), it remains unclear whether their reduction contributes to clinical symptoms. The results of this study in human samples show lower levels of SHANK3a in AD brain, correlating with cognitive decline. Data gathered in a novel transgenic mouse suggest that Shank3a deficiency synergizes with AD neuropathology to induce cognitive impairment, consistent with a causal role in AD. Therefore, treatment aiming at preserving Shank3 in the aging brain may be beneficial to prevent AD.
Ovol1/2 loss‐induced epidermal defects elicit skin immune activation and alter global metabolism
Authors: Dragan Morgan , Chen Zeyu , Li Yumei , Le Johnny , Sun Peng , Haensel Daniel , Sureshchandra Suhas , Pham Anh , Lu Eddie , Pham Katherine Thanh , Verlande Amandine , Vu Remy , Gutierrez Guadalupe , Li Wei , Jang Cholsoon , Masri Selma , Dai Xing
Published: May 2023

Skin epidermis constitutes the outer permeability barrier that protects the body from dehydration, heat loss, and myriad external assaults. Mechanisms that maintain barrier integrity in constantly challenged adult skin and how epidermal dysregulation shapes the local immune microenvironment and whole‐body metabolism remain poorly understood. Here, we demonstrate that inducible and simultaneous ablation of transcription factor‐encoding Ovol1 and Ovol2 in adult epidermis results in barrier dysregulation through impacting epithelial‐mesenchymal plasticity and inflammatory gene expression. We find that aberrant skin immune activation then ensues, featuring Langerhans cell mobilization and T cell responses, and leading to elevated levels of secreted inflammatory factors in circulation. Finally, we identify failure to gain body weight and accumulate body fat as long‐term consequences of epidermal‐specific Ovol1/2 loss and show that these global metabolic changes along with the skin barrier/immune defects are partially rescued by immunosuppressant dexamethasone. Collectively, our study reveals key regulators of adult barrier maintenance and suggests a causal connection between epidermal dysregulation and whole‐body metabolism that is in part mediated through aberrant immune activation.
O‐GlcNAcylation promotes topoisomerase IIα catalytic activity in breast cancer chemoresistance
Authors: Liu Yangzhi , Yu Kairan , Zhang Keren , Niu Mingshan , Chen Qiushi , Liu Yajie , Wang Lingyan , Zhang Nana , Li Wenli , Zhong Xiaomin , Li Guohui , Wu Sijin , Zhang Jianing , Liu Yubo
Published: May 2023

DNA topoisomerase IIα (TOP2A) plays a vital role in replication and cell division by catalytically altering DNA topology. It is a prominent target for anticancer drugs, but clinical efficacy is often compromised due to chemoresistance. In this study, we investigate the role of TOP2A O‐GlcNAcylation in breast cancer cells and patient tumor tissues. Our results demonstrate that elevated TOP2A, especially its O‐GlcNAcylation, promotes breast cancer malignant progression and resistance to adriamycin (Adm). O‐GlcNAcylation at Ser1469 enhances TOP2A chromatin DNA binding and catalytic activity, leading to resistance to Adm in breast cancer cells and xenograft models. Mechanistically, O‐GlcNAcylation‐modulated interactions between TOP2A and cell cycle regulators influence downstream gene expression and contribute to breast cancer drug resistance. These results reveal a previously unrecognized mechanistic role for TOP2A O‐GlcNAcylation in breast cancer chemotherapy resistance and provide support for targeting TOP2A O‐GlcNAcylation in cancer therapy.
The Analysis of Leverage, Return on Assets, and Firm Size on Tax Avoidance
Authors: Paramita Astriyani Sandya , Ardiansah Muhammad Noor , Delyuzar Raissa Arham , Dzulfikar Arif
Published: May 2023

Purpose : The study aims to analyze the effect of leverage, return on assets, and firm size on tax avoidance in Property and Real Estate Companies listed on the Indonesia Stock Exchange (IDX) for the 2010-2016 period.

Method : The population in this research are real estate companies listed on the Indonesia Stock Exchange. The sample selection process in this research used a purposive sampling method. Testing the effect of leverage, return on assets, and firm size on tax avoidance is done using multiple linear regression analysis models.

Findings : Based on the results of the study, the CETR level is positively and significantly influenced by the level of return on assets and company size. Meanwhile, CETR is negatively and significantly affected by the level of leverage.

Novelty : In this study, the sample is focused on property and real estate companies listed on the Indonesia Stock Exchange based on sharia stocks because related research has not been widely studied, so it is necessary to do more about tax avoidance in sharia stocks.

Keywords : Tax Avoidance; Return on Assets; Leverage; Firm Size
What Factors Determine Banking Profitability In Indonesia During The Covid-19 Pandemic?
Authors: Rohman Abdul , Nurkhin Ahmad
Published: May 2023

Purpose : The banking industry faced significant challenges during the COVID-19 pandemic. Banking performance is being scrutinized for interested parties to evaluate future business projections. The purpose of this study is to analysis the profitability of Indonesian banks during the COVID-19 pandemic and to investigate what factors influence the profitability.

Method : This research is quantitative research and uses panel data. The research sample is a banking company listed on the Indonesia Stock Exchange with a two-year observation period (2020-2021), that is, during the COVID-19 pandemic. There are 49 banks and unbalanced panel data obtained from 97-unit analysis. Return on Assets (ROA), Return on Equity (ROE), and Net Interest Margin are all used to measure banking profitability (NIM). The documentation method was used to collect data. The data was analyzed using descriptive statistics and multiple regression analysis with random effect model.

Findings : The result indicate that only NPL has a significant negative effect on ROA and ROE, according to the findings. Meanwhile, even though it is negative, CAR has a significant impact on ROA and ROE. The effects of size and liquidity on ROA and ROE were not significant. Similarly, there is no significant evidence of size, liquidity, CAR, or NPL on the Indonesian banking NIM. It can be concluded that only NPL and CAR have a significant impact on Indonesian banking profitability.

Novelty : The novelty in this paper is an analysis of banking profitability in Indonesia during the COVID-19 pandemic (2020-2021) and a study of the factors that influence it. Unbalanced data panel regression with random effect model was used to analyze the data.

Keywords : Profitability; Return on Assets; Return on Equity; Net Interest Margin; Non-Performing Loan
Mesenchymal stem cell secretome alters gene expression and upregulates motility of human endometrial stromal cells
Authors: Zhao Qingshi , Larios Karla , Naaldijk Yahaira , Sherman Lauren S , Chemerinski Anat , Okereke Kennisha , Rameshwar Pranela , Lemenze Alexander , Douglas Nataki C , Morelli Sara S
Published: May 2023

In brief

Endometrial stromal cell motility is fundamental to regeneration and repair of this tissue and crucial for successful reproduction. This paper shows a role for the mesenchymal stem cell (MSC) secretome in enhancing endometrial stromal cell motility.

Cyclic regeneration and repair of the endometrium are crucial for successful reproduction. Mesenchymal stem cells (MSCs) derived from bone marrow (BM-MSC) and umbilical cord (UC-MSC) facilitate tissue repair via their secretome, which contains growth factors and cytokines that promote wound healing. Despite the implication of MSCs in endometrial regeneration and repair, mechanisms remain unclear. This study tested the hypothesis that the BM-MSC and UC-MSC secretomes upregulate human endometrial stromal cell (HESC) proliferation, migration, and invasion and activate pathways to increase HESC motility. BM-MSCs were purchased from ATCC and cultured from the BM aspirate of three healthy female donors. UC-MSCs were cultured from umbilical cords of two healthy male term infants. Using indirect co-culture of MSCs and hTERT-immortalized HESCs via a transwell system, we demonstrated that co-culture of HESCs with BM-MSCs or UC-MSCs from all donors significantly increased HESC migration and invasion, whereas effects on HESC proliferation varied among BM-MSC and UC-MSC donors. Analysis of gene expression by mRNA sequencing and RT-qPCR showed that expression of CCL2 and HGF was upregulated in HESCs that had been cocultured with BM-MSCs or UC-MSCs. Validation studies revealed that exposure to recombinant CCL2 for 48 h significantly increased HESC migration and invasion. Increased HESC motility by the BM-MSC and UC-MSC secretome appears to be mediated in part by upregulated HESC CCL2 expression. Our data support the potential for leveraging MSC secretome as a novel cell-free therapy to treat disorders of endometrial regeneration.
“ŞÜPHELİNİN KOLLUK TARAFINDAN ALDATILMASI”
Authors: GÖKPINAR Mahmut
Published: May 2023

Ceza muhakemesinde şüpheli-sanığın irade özgürlüğünün müdahaleye en açık olduğu ve bu nedenle de yaşamsal öneme sahip olduğu devre, soruşturma evresidir. Bu süreçte, kolluk tarafından gerçekleştirilen özellikle ifade alma olmak üzere kimi işlemlerde onun iradesi aleyhine meydana gelen ihlaller, bazı durumlarda kendisi hakkında verilecek hükmün maddi gerçekle bağdaşmayacak şekilde ortaya çıkmasına neden olacaktır. Bu ihlallerin en önemlisi kolluk tarafından gerçekleştirilen aldatmadır. Şüphelinin yapılan işlemin ve karşısındakinin kolluk görevlisi olduğunun farkında olduğu halde aldatılması mümkündür. Bunun dışında işlemi ya da gerçekleştireninin asıl kimliğini bilmeksizin de aldatılabilir. Şüphelinin bilgi verdiği, sponton açıklama yaptığı, dinleme tuzaklarına maruz kaldığı sırada bir müdafii yardımı alma imkanının olmaması konuyu daha da önemli hale getirmektedir. Soruşturma sırasında cezai kurnazlık, vazgeçilmesi mümkün olmayan bir hususu oluşturmaktadır. Kanunların kriminalistik bir kurnazlığı yasaklaması söz konusu olamaz. Bu nedenle de bir davranışın aldatma teşkil edip etmediği, dar bir şekilde yorumlanmalıdır. Şüpheliye karşı kurnazca davranışlar sergileyerek itiraf almak ile onu yanıltarak karar verme iradesini fiilen elinden almak suretiyle itiraf elde etmek birbirinden farklıdır
“People’s libraries” of the Society of zealots of Russian historical enlightenment at the turn of the 19th and 20th centuries
Authors: Yu Jie
Published: May 2023

At the beginning of the reign of Nicholas II, representatives of the conservativeoriented élite and their supporters from other social strata established the Society of Zealots of Russian Historical Enlightenment in memory of Emperor Alexander III with the aims of maintaining the ideological course of the Emperor (who died in 1894), as well as preventing the return to the reforms in the spirit of Alexander II. One of the directions of its activity was propaganda of political values of Alexander III among common people. For this purpose, in the late 1890s the society began to organise “people’s libraries”, where rural and urban residents could read the relevant ideological literature and where educational talks would be held with them within the ideological guidelines of the Society. The Society’s leadership was careful in deciding who among its members would be entrusted with the organisation of such libraries. To prevent the libraries from receiving ideologically undesirable literature, a complex centralised system of supplying them with both already published editions and new ones was developed. In the fi rst years of its implementation, before the political crisis of 1905–1906 and following liberal reforms, this project of the Society can generally be regarded as successful. An extensive network of libraries was established throughout Russia, and these librarians managed to handle the demands of their users. However, this stage witnessed a growing interest of readers in current events and the necessity to provide libraries with periodicals. Readers were mainly interested in fi ction and popular historical works, while spiritual literature was less asked for, except for the period of Lent. Later, during the liberalisation of the internal political life of the country, these trends could not but create diffi culties for libraries in terms of maintaining their ideological orientation.
Documents of the authorities of Moscow diocese on penitential prayers in the territory of Moscow on the occasion of national disasters in 1919
Authors: Borisyuk Andrey
Published: May 2023

The publication presents documents of the Moscow Diocesan authorities related to the organization of national penitential events in 1919: the Message of Archbishop Joasaph (Kallistov) on the need for repentance from August 2, 1919, the Decree of the Moscow Diocesan Council on penitential services, Appendices to the decree: permanent additions to the services (litanies and penitential prayer), the Brochure "Repentance is the need of our time". These documents appeared as a reaction of the diocesan authorities to the nationwide disasters that occurred after the revolution (poverty, famine, epidemics) and were sent to the churches of the Moscow Diocese. They contain both practical instructions of a liturgical nature and a theoretical understanding of the events taking place from a theological point of view. The hardships of the time experienced are perceived in these sources as the result of a sin that requires repentance. The idea is substantiated that without the elimination of the spiritual causes of disasters, any other struggle against them will not be successful. The need to organize special church penitential events was noted by the supreme Ecclesiastical authority (represented by the Patriarch), and was also the most important activity of the Moscow Diocesan Council in 1919, while to this day this activity remains practically unexplored. The documents presented in this article are published for the first time.
Two letters of commendation to st. Evfrosin of Pskov about the lands for the monastery (1450s — 1465)
Authors: Postnikov Arsenii
Published: May 2023

The article reports on the discovery of new texts of Pskov charateic charters of the XV – beginning of the XVI century, originating from the patrimonial archive of the Three-Holy Eleazar Monastery. They were preserved in the form of lists around 1732. The discovery was made by the author during the work on the identification and scientific description of the available composition of documents of the XVI–XVIII centuries. in the collection of the Ancient Repository of the Pskov Museum. The study showed that the Copy Notebook found as part of the book binding includes lists with 21 letters. Among them are complete documents and their fragments. This publication presents the experience of studying two acts from the Copy Book of the Three-Holy Monastery. These are certificates No. 6 and No. 11 in order in the collection. They are remarkable in that they are directly related to the history of the monastery's creation, since in the middle of the XV century they were given to the Most Reverend Euphrosyne on the land for the monastery he had built. The plots of land were located in the Krivovitsky rural district of the Belsky ambush of Pskov County between the Tolva River and a small forest lake. Transferred from the previous owners "to oderen", that is, to full unconditional ownership, they created the core of the patrimony and remained with the current monastery, despite the later secularization of 1764. The same lands are part of the modern borders of the restored monastery. Temples, monastic cells, a cemetery, a refectory, a cow village, a hotel and all other buildings necessary for a statutory life are located on them. The new letters of the era of the Veche Pskov are a valuable source for the study of the ancient Pskov script, the ancient topography of the Pskov land, church history and monastic land ownership.
The Effect of Creating 3D Objects with Block Codes on Spatial and Computational Thinking Skills
Authors: Küçük Mehmet , Talan Tarık , Demirbilek Muhammet
Published: May 2023

This study investigated the effects of 3D model building activities with block codes on students' spatial thinking and computational thinking skills. The study group consists of 5th grade students in a secondary school in the Central Anatolia region of Turkey. For the study, a pretest-posttest control group was utilized within the experimental design. A total of 66 students participated, 23 in the experimental group and 43 in the control group. While the activities prepared on the Tinkercad platform were applied in the experimental group, the courses were taught using the traditional teaching method in the control group. The study covers a period of three-weeks in the course information technologies and software. The study used the computational thinking levels scale and spatial thinking test scales as data collection instruments. The data was analyzed using both descriptive statistics and independent samples t-tests. Based on the study findings, there were no significant differences observed in the levels of computational thinking skills levels and spatial thinking test scores between the experimental and control groups.
CRYPTOPOETICS OF V. NABOKOV’S NOVEL “THE REAL LIFE OF SEBASTIAN KNIGHT”
Authors: Kibalnik Sergey
Published: May 2023

The article examines the cryptopoetics of V. V. Nabokov’s first Eng- lish-language novel “The Real Life of Sebastian Knight” (1938–1939). It demon- strates that this novel is a curious example of the writer’s cryptopoetics, in which many specific circumstances of his personal life were obscured and radically transformed. A special role in the cryptopoetics of the novel is played by the allusive chess symbolism, which has been discussed more than once, but the meaning of which remained unclear. The key to this meaning turns out to be the deeply camouflaged autobiographical subtext of “The Real Life…”. Written shortly after Nabokov’s profound infatuation with Nina Guadanini, this novel is structured this way to show that Sebastian Knight’s only true love was Claire Bishop, and Madame Lecerf (Nina Toorovetz-Rechnoy) was just an episode in his life. The chess mystery of the novel, in which the queen (Madame Lecerf) is defeated by the bishop (Claire Bishop), is set up in unison with this motif. Meanwhile, the surname of the heroine of the novel “Bishop” allusively refers to the writer’s wife Vera Slonim. Thus, not only the crypto-, but also the psychopoetics of the novel is important for understanding the text
PARAPHRASES AND PARALLELS IN THE 1917–1918 FEUILLETONS BY A. V. AMFITEATROV
Authors: Alexandrov Alexander
Published: May 2023

The article focuses on the poetic devices that are a part of the artistic system of A. V. Amfiteatrov, a well-known publicist and prose writer, a leading feuilletonist of the early 20th century. The subject of the study is his feuilletons of the post-Revolution period published in Russia until August 1918. The paper reveals the political stance of the publicist on the revolutionary events of 1917, his attitude to the February and October revolutions. The paper provides an overview of the themes and plots of Amfiteatrov’s printed speeches of this period — these are the responses to socio-political events and social issues. Further, the paper analyzes specific examples of rhetorical devices from his articles — direct parallels, paraphrases, deliberate citation of works of classical literature. The author’s artistic and ideological goal-setting paradigms are traced; the critical attitude of the author to the post-revolutionary reality that emerges through comic techniques is revealed. The main sources of paraphrases and parallels for Amphiteatrov are, first of all, satirical works from Russian classical literature — N. V. Gogol, M. E. Saltykov-Shchedrin; as well as G. I. Uspensky, A. P. Chekhov and L. N. Tolstoy, M. Gorky. He extrapolates the quotes and specific situations from these texts onto contemporary reality. The article also provides unknown biographical facts related to the life and work of the publicist in 1917–1918.
Paid Family Caregiving for Children With Medical Complexity
Authors: Brittan Mark S. , Chavez Catia , Blakely Christy , Holliman Brooke Dorsey , Zuk Jeannie
Published: May 2023

OBJECTIVES

We evaluated Colorado’s paid family caregiver certified nursing assistant (CNA) program by assessing stakeholders’ perceptions of the model’s strengths and potential areas for improvement.

METHODS

A professional bilingual research assistant conducted key informant interviews of English- and Spanish-speaking certified nursing assistant (CNA) family caregivers (FCs), primary care providers, and pediatric home health administrators of children with medical complexity in the family caregiver CNA program. Interview questions focused on the program’s benefits, drawbacks, and implications for the child and caregiver’s quality of life. Transcripts were coded and analyzed, and themes summarizing program benefits and disadvantages were identified.

RESULTS

Semistructured interviews were completed by phone with 25 FCs, 10 home health administrators, and 10 primary care providers between September 2020 and June 2021. Overall, the program was highly valued and uniformly recommended for prospective families. Perceived benefits included: (1) fulfilling the desire to be a good parent, (2) providing stable and high-quality home health care, (3) benefitting the child’s health and wellbeing, and (4) enhancing family financial stability. Perceived drawbacks included: (1) FCs experiencing mental and physical health burdens, (2) difficult access for some community members, (3) extraneous training requirements, and (4) low program visibility.

CONCLUSIONS

Given the perceived benefits of the family CNA program, the model may be considered for future dissemination to other communities. However, additional research and program improvements are needed to help make this a more equitable and sustainable home health care model for children with medical complexity.
ІННОВАЦІЙНА ТЕХНОЛОГІЯ ПІДГОТУВАННЯ ВОДИ ДЛЯ ВИРОБНИЦТВА ФЕРМЕНТОВАНОГО НАПОЮ КОМБУЧА
Authors: Дулька Ольга С. , Прибильський Віталій Л. , Федосов Олексій Л. , Олійник Світлана І. , Куц Анатолій М. , Шаран Лариса О. , Корецька Ірина Л. , Тюрікова Інна С.
Published: May 2023

У статті наведено результати теоретичних та експериментальних досліджень з удосконалення технології підготовки води для виробництва безалкогольного ферментованого напою комбуча. Комплексна дія досліджених матеріалів із адсорбційними, іонообмінними та окисно-відновними властивостями забезпечує кондиціювання води та інтенсифікацію технологічного процесу, досягнення високих органолептичних показників готового продукту. Встановлено доцільність використання клиноптилоліту, гірського кришталю та активного вугілля у технології підготовки води для приготування комбучі. При обробці води з різних джерел запропонованими матеріалами зменшувалась її загальна жорсткість, вміст загального заліза, збільшувався вміст біологічно активних речовин в готовому напої, покращувались органолептичні характеристики. В готовому напої збільшувався вміст поліфенольних речовин в середньому у 2,7 рази у порівнянні з використанням необробленої води. Встановлено, що висока жорсткість води негативно впливала зброджування сусла культурою Medusomyces gisevii та погіршувала органолептичні якості готового напою. Визначено кореляцію між показниками води, динамікою бродіння сусла та органолептичною оцінкою готових напоїв. Найвищу органолептичну оцінку отримали зразки напою, що приготовлені з використанням води, обробленої послідовно клиноптилолітом, активним вугіллям та гірським кришталем.
ДОСЛІДЖЕННЯ ІНФРАЧЕРВОНИХ СПЕКТРІВ ГЕЛЕВИХ СИСТЕМ НА ОСНОВІ АГАРУ ДЛЯ ВИРОБНИЦТВА ЖЕЛЕЙНИХ БАТОНЧИКІВ
Authors: Боковець Сергій П. , Перцевой Федір В. , Мурликіна Наталя В. , Сметанська Ірина М. , Боранкулова Асель С. , Янчик Марія В. , Омельченко Світлана Б. , Гринченко Ольга О. , Гринченко Наталя Г. , Діхтярь Альона М. , Котляр Олег В. , Ярмош Тетяна А.
Published: May 2023

Метою роботи було визначення впливу гліцерину TM BASF, меду соняшникового та порошку кунжутного TM "Korysne Boroshno" на стан води у гелевих системах на основі агару 1200 ТМ "Fujian Province" для виробництва желейних батончиків. Дослідження проводили із застосуванням інфрачервоної спектроскопії на Фурьє-спектрометрі Perkin-Elmer Spectrum One FTIR Spectrometer. Було встановлено, що процес гелеутворення в системі «агар-вода-гліцерин» супроводжується перерозподілом асоційованих і неасоційованих груп ОН, збільшенням кількості асоційованих гідроксилів та адсорбційнозвязаної води, що підтверджується появою у ІЧ спекрі широкої інтенсивної смуги поглинання в області 3700–2600 см–1 характерної для валентних коливань ОН-групи. Додавання меду до гелевої системи призводить до зміни інтенсивності смуги валентних коливань зв’язку С–С у вуглеводах меду (при 1245 см–1) та зміщення її у бік вищих частот порівняно з гелем «агар-вода-гліцерин», що підтверджується наявністю смуги поглинання в області 1200–700 см–1. Також дані спектроскопії показали, що додавання кунжутного порошку при виготовленні гелю на основі агару, знизило інтенсивність валентних коливань ОН групи води (2151 cm–1), а також призвело до зсуву інтенсивної широкої смуги у бік вищих частот порівняно з гелями без кунжуту (2139 см–1).
ФАЗОВІ РІВНОВАГИ В СИСТЕМІ La2O3-Lu2O3-Er2O3 ЗА 1500 і 1600 °
Authors: Чудінович Ольга В. , Широков Олександр В. , Самелюк Анатолій В.
Published: May 2023

Фазові співвідношення в потрійній системі La2O3-Lu2O3-Er2O3 за 1500 і 1600 °С вивчали в усьому діапазоні концентрацій методами рентгенівської дифракції (РФА) і скануючої електронної мікроскопії (СЕМ). Як вихідні речовини використовували оксиди La, Lu та Er (99.99 %). Зразки готували з кроком концентрування 1–5 мол. %. Оксиди розчиняли в HNO3 (1 : 1) з наступним випарюванням розчинів і розкладанням нітратів за 800 °C протягом 2 годин. Зразки піддавали термічній обробці за 1500 °C (протягом 70 годин) та 1600 °C (протягом 10 годин) на повітрі. Фазовий склад досліджуваних зразків вивчали за допомогою рентгенофазового (РФА, ДРОН-3), мікроструктурного та електронно-мікрозондового (Superprobe-733, JEOL, Японія, Пало-Альто, Каліфорнія) аналізів. У системі виявлено тверді розчини на основі різних поліморфних форм вихідних оксидів і впорядкованих фаз LaLuO3 (LaErO3). Нових фаз у системі не виявлено. Ізотермічні перерізи фазової діаграми стану La2O3-Lu2O3-Er2O3 при 1500 і 1600 °С характеризуються наявністю трьох однофазних (A-La2O3, R, C-Lu2O3 (Er2O3)) і двох двофазних (C+R, A+R) областей. Система утворює безперервні серії твердих розчинів на основі кубічної модифікації C-Lu2O3(Er2O3) та впорядкованої фази типу перовскіту (R-фаза). Визначено межі розчинності та побудовано концентраційні залежності періодів і параметрів ґратки елементарної комірки фаз, що утворюються в системі. Діапазон гомогенності твердих розчинів на основі R-фази простягається від 46 до 54 мол. % La2O3 за 1500 °C і від ~48 до 54 мол. % La2O3 за 1600 °C. Оксиди лютецію та ербію утворюють неперервний ряд твердих розчинів оксидів C-REE.
ВПЛИВ ПАРАМЕТРІВ ЕКСТРАГУВАННЯ НА ВЛАСТИВОСТІ СУБКРИТИЧНИХ ВОДНИХ ЕКСТРАКТІВ СОЄВОГО ШРОТУ
Authors: Сукманов Валерій О. , Ковальчук Олена В.
Published: May 2023

Робота присвячена дослідженню процесу екстрагування субкритичною водою соєвого шроту та впливу па-раметрів екстрагування на властивості рідких та сухих екстрактів. Метою дослідження є встановлення впли-ву параметрів процесу субкритичного водного екстрагування (температура: 120–160 °С, тривалість екстра-гування: 5…15 хв, гідромодуль: 1 : 15…25) на властивості рідких та сухих екстрактів соєвого шроту та їх опти-мальних значень. Характер залежності показників екстрактів від параметрів процесу екстрагування встано-влено емпірично. Для визначення коефіцієнтів інтерполяційної моделі було заплановано проведення дроб-нофакторного експерименту 33–1 за ортогональним композиційним планом 2-го порядку. Рідкі екстракти отримано на лабораторній установці на базі реактора високого тиску. Сухі екстракти отримували методом випарювання. Для рідких екстрактів визначали pH та вміст сухих речовин. Для сухих екстрактів визначали вміст мінеральних речовин, залишкової води, білку та ізофлавонів. Аналіз екстрактів виконували за інструментальними методиками відповідно до вимог Державної фармакопеї України, із використанням сучасного обладнання. Встановлено коефіцієнти квадратичних інтерполяційних моделей, аналіз яких дозволив встановити оптимальні параметри екстрагування. Встановлено, що на досліджуваних діапазонах тривалості та температури екстрагування вміст сухих речовин у рідких екстрактах та вміст білка у сухих екстрактах мають максимуми, величина яких монотонно зростає зі збільшенням частки води в екст-ракційній суміші. Вміст мінеральних речовин мав максимум лише за температурою, а ізофлавонів – за трива-лістю екстрагування. Отримані результати можуть бути використані при удосконаленні технології отриман-ня соєвих білкових концентратів та ізолятів із застосуванням методу субкритичного водного екстрагування.
Mujeres del Sur en el quehacer teatral costarricense (1970-1990)
Authors: Gutiérrez Rojas Marisol , Barrionuevo Claudia
Published: May 2023

Esta investigación identifica y sistematiza los aportes de las chilenas Carmen Bunster, Sara Astica y Bélgica Castro y las argentinas Haydée de Lev, Gladys Catania y Ana María Barrionuevo, en tres décadas medulares para las artes escénicas de Costa Rica: 1970-1990. La actuación, la enseñanza del teatro y la divulgación de la tarea teatral, así como el trabajo en cine, radio o actividades gremiales, marcan el trabajo de estas mujeres quienes, por migración voluntaria o por exilio político, llegaron al país. La revisión del contexto cultural y teatral de esos treinta años del siglo pasado evidencian un camino que va desde la profesionalización del teatro en la década de 1970 hasta el teatro comercial y ligero de la década de 1990, pasando por las interrogantes de un teatro de 1980 en busca de su identidad.
Women freemasons in Hungary from the beginnings
Authors: Vári László
Published: May 2023

Resistance to women's freemasonry is slowly dissolving in Hungary. It was only after the change of regime (1990) that women's and mixed lodges of foreign origin were established in Hungary. In the history of Hungarian freemasonry there have been only three Hungarian women were initiated in the 18th century, two were admitted to lodges in the 19th century. The only female masonic-like organisation in Hungary, the Eastern Star, died shortly after its foundation. Despite the lack of tradition, today we can speak of a well-functioning mixed and a women's lodge.
cuestión masónica en la izquierda italiana
Authors: Novarino Marco
Published: May 2023

La moción antimasónica, votada en el congreso del Partido Socialista Italiano (PSI) de 1914, zanjó una polémica en el movimiento socialista desde principios del siglo XX y que había creado una cesura en las relaciones entre las dos organizaciones. Cuando, en 1919, el PSI decidió adherirse a la nueva Internacional comunista, la polémica antimasónica formó parte de los debates en los congresos de antes de la muerte de Lenin. Sobre todo, cuando resultó claro que muchos socialistas-masones se habían adherido al Partido comunista francés, la Internacional, principalmente por voluntad de Trotsky, que adoptó posiciones muy rígidas sobre la cuestión.
Inhabilitación absoluta y perpetua de Vicent Sampedro Ramo
Authors: Vicente Sánchez Hector
Published: May 2023

Reseña del libro Inhabilitación absoluta y perpetua. La represión franquista contra los masones de Castelló de Vicent Sampedro Ramo. Castelló de la Plana: Universitat Jaume I, 2020. 374 páginas. ISBN: 978-84-17900-86-1.
masonería española en el exilio
Authors: Cruz Orozco José Ignacio
Published: May 2023

La masonería española sufrió un duro exilio al finalizar la Guerra Civil. Más de un millar de masones se vieron obligados a salir del país. y un grupo destacado pudo reconstruir sus estructuras básicas en México. Las relaciones entre las potencias de ese país y las españolas estuvieron presididas, por lo que se ha podido documentar, por el acuerdo y la solidaridad. Las americanas concedieron decretos de asilo a las españolas y apoyaron en sus reivindicaciones contra el régimen franquista. En correspondencia, las españolas expresaron repetidamente su agradecimiento a las mexicanas, en especial a la Gran Logia Valle de México.
Geopolítica y masonería en el proyecto de Parques Nacionales de Lázaro Cárdenas
Authors: Huerta García Marco Antonio
Published: May 2023

Este trabajo tiene como objetivo revelar el vínculo geopolítico de la masonería con el proyecto de parques nacionales en el sexenio del general Lázaro Cárdenas, derivado del análisis de fuerzas políticas de las entidades federativas y de los servicios ecosistémicos de sobresaliente necesidad para la población. En una primera parte, se presenta un análisis geopolítico de los decretos cardenistas investigados. En la segunda, se identifica la pertenencia masónica de varios gobernadores de los 18 Estados y ecorregiones donde se expandió el proyecto de parques nacionales, que permite apreciar la importancia de estos vínculos geopolíticos y masónicos entorno a Cárdenas.
Estudios de la masonería en América Latina y el Caribe, eds. Mariana Annecchini, Yván Pozuelo Andrés y Ana María T. Rodríguez
Authors: Aragón Rogelio
Published: May 2023

Estudios de la masonería en América Latina y el Caribe: Siglos xix y xx, editado por Mariana Annecchini, Yván Pozuelo Andrés y Ana María T. Rodríguez. Santa Rosa, Argentina: IEHSOLP Ediciones, 2020. 272 páginas. ISBN 978-98-74752-628.
Katipunan
Authors: Cuartero Escobes Susana
Published: May 2023

En el último tercio del siglo XIX el Pacífico español se había convertido en un incontrolable polvorín. Diversas cuestiones no resueltas y agravadas con el paso del tiempo, confluyeron en la misma trayectoria y los maltrechos cimientos de una agotada metrópoli se vinieron abajo mediante una insurrección. La política que la monarquía borbónica imprimió en sus posesiones ultramarinas fue fraguando en un movimiento nacionalista anticolonial y antimasónico que llegó a su culmen en 1896 con la sublevación tagala y a la ruptura definitiva con España en 1898.
Antimasonería y anticlericalismo
Authors: García Robles Marco Antonio
Published: May 2023

En el presente texto se muestran hechos y documentaciones de diferentes etapas históricas en México relacionadas con la masonería y la oposición de las agrupaciones religiosas, especialmente, pero no exclusivamente, la católica. Se incluyen ejemplos de publicaciones antimasónicas, con énfasis en contra del Rito de York y el Rito Escocés Antiguo y Aceptado; además, se cuenta hechos poco conocidos, como la difusión de listas negras de masones entre los “cristeros” o la participación de diplomáticos masones en ceremonias religiosas en el Vaticano.
ANALISIS TERHADAP PEMBAGIAN WARISAN BAGI ANAK PEREMPUAN PERSPEKTIF HUKUM ISLAM
Authors: Syahrial Mohd , Asasriwarni Asasriwarni , Elfia Elfia
Published: May 2023

Studi ini menyorot jumlah bagian warisan untuk anak perempuan lebih besar dari bagian warisan untuk anak anak laki-laki berdasarkan beberapa kasus yang ada di Kecamatan Tanah Cogok. Pembagian warisan terhadap anak perempuan ini dilaksanakan melalui cara ishlah. Adapun tujuan yang ingin dicapai dalam tesis ini adalah: (1) Untuk mengetahui alasan, cara, pendapat para ulama serta tokoh adat dan perspektif hukum Islam terhadap Pembagian warisan hanya untuk anak perempuan. Penelitian ini menggunakan metode penelitian empiris, yaitu penelitian dengan adanya data-data lapangan sebagai sumber data utama. Berdasarkan hasil penelitian dapat disimpulkan bahwa pembagian warisan terhadap anak perempuan di Kecamatan Tanah Cogok adalah: (1) Alasan perempuan mendapatkan bagian warisan lebih banyak dari laki-laki adalah: tingkat kesulitan dalam menjaga serta mengurus kedua orang tua semasa masih hidup, sedangkan laki-laki sibuk dengan pekerjaannya sendiri. (2) cara pembagian warisan adalah: Warisan dibagikan setelah pewaris meninggal dunia serta setelah dilunasi semua hutang-hutangnya. (3) Pendapat toko adat dan ulama adalah dengan cara ishlah, dalam pembagian tersebut mereka tidak menemukan perseteruan antara ahli waris karena telah saling ridha. Kelompok toko ulama dan toko adat tidak setuju dengan alasan bahwa cara tersebut tidak sesuai dengan ketentuan hukum waris Islam. (4) praktek pelaksanaan pembagian warisan terhadap perempuan di Kecamatan Tanah Cogok secara teori tidak sejalan dengan hukum kewarisan Islam karena telah bertentangan dengan beberapa prinsip asas ijbari.
PROBLEMS IN THE IMPLEMENTATION OF ISLAMIC LAW IN THE CONTEMPORARY ERA
Authors: Meirison Meirison , Yusna Darni
Published: May 2023

One of the biggest obstacles to applying Islam as a social system in the modern secular state is the dilemma of codifying the provisions of Islamic Sharia within the mold of the Western legal system. Methods of preparing and promulgating those laws. Islamic Sharia, in its essence, is spiritual and devotional, and its material legislation tends to organize society so that it is possible to establish the orders of religion, achieve its purposes for people, and reform their conditions in this world and the Hereafter. Therefore, Sharia does not know boundaries, geographical boundaries, and the boundaries between this world and the Hereafter. And because the purposes of Western legislation are, in essence, purely materialistic, it seeks to achieve immediate material benefit to society. It does not concern itself with the condition of people in the Hereafter. The invocation of the concept of the Hereafter is a limit. The same when discussing Western legislation may cause ridicule and belittling among its supporters; Therefore, the hegemony of Western legislation with its vocabulary over Islam would result in a significant dilemma. The imams who are followed and accepted by a group of people, or the scholars whom others trust and obey, are human beings who make mistakes and are right. Their rulings are necessarily and inevitably affected by the level of knowledge, intelligence, integrity, whim, error, ignorance, and bias. When applying these rulings, they naturally need authority compelling political and capable of executing and implementing the provisions. And this authority is gained power by predominance and control, or the people elect it. Thus, whoever decides legitimacy is either a dominant political-military authority or an elected politician protected by a social contract upon which all or most of the citizens agree!
Investigating gaming structural features associated with gaming disorder and proposing a revised taxonomical model: A scoping review
Authors: Saini Nirav , Hodgins David Carson
Published: May 2023

Background and aims

Gaming disorder (GD) is a mental health concern that has been heavily contested by experts. This scoping review synthesizes the literature to identify the structural features of video game design that can contribute to GD. Furthermore, a taxonomy of the structural features implicated with GD is proposed, revised from earlier work.

Methods

Seven databases, in addition to Google Scholar, were searched. Peer-reviewed studies were included if they assessed a link between gaming structural characteristics and GD or a proxy. The final pool included 105 articles.

Results

Avatar creation and customizability, multiplayer characteristics, and reward and punishment features were highly represented in the literature. There was no evidence for three categories in the original taxonomy: support network features, sexual content, and explicit language. Furthermore, structural feature sub-categories emerged that were absent from the previous taxonomy, such as general socialization features, type of virtual world, and in-game currency. Manipulation and control features and presentation features were less represented than social features, narrative and identity features, and reward and punishment features. The reviewers propose two broad classes of addictive gaming structural features: ‘features enhancing in-game immersion and realism’ and ‘gambling-like features’.

Discussion and conclusions

Numerous studies found a relationship between social, narrative and identity, and reward and punishment structural characteristics with GD. Two broad classes of gaming structural features were associated with addiction. The first, ‘features enhancing in-game immersion and realism,’ including social gameplay, avatar creation, storytelling, and graphics/sound. The second, ‘gambling-like features,’ included different mechanisms of rewards-and-punishment.
Achieving optimal physical fitness and health safety in 19-21 year old judo athletes
Authors: Boychenko Natalia , Jagiello Wladyslaw
Published: May 2023

Background and Study Aim. Physical fitness is crucial for the success of athletes in competitive sports. However, often the impact of physical exertion on athlete health is overlooked. The study aims to investigate the relationship between the level of physical fitness and competitive performance of judokas aged 19-21.
Material and Methods. Judo athletes (n=30) participated in the study. The study used video recordings of competitive bouts of 30 judokas aged 19-21 in different weight categories. The athletes were tested for various physical fitness indicators, including strength endurance, coordination abilities, speed-strength abilities, endurance, speed abilities, and flexibility. The SPSS 22 program was used to conduct correlation analysis.
Results. The study showed that throws Ippon Seoi Nage, Seoi Otoshi, Kо soto Gake, O Uchi Gari and Ko uchi gar, Ko Soto Gari were the most commonly used techniques across all weight categories. Lighter weight categories favored a throw over the head (Sumi Gaeshi, Tomoe Nage) with an emphasis on speed and coordination, while heavier weight categories favored bending throws (Ura nage) that required strength and flexibility.
Conclusions. Based on the study findings, a list of recommended technical judo techniques for each weight category has been proposed. These recommended techniques are closely related to the athletes' level of physical fitness, and coaches can use them to optimize training programs for young judokas.
The influence of volleyball classes on the physical fitness and health outcomes of college students
Authors: Shesterova Lyudmila , Piatnytska Daria , Gryshchenko Lyudmila , Wnorowski Krzysztof
Published: May 2023

Background and Study Aim. The difficult situation in Ukraine related to military operations has created significant challenges for education and sports. This study aimed to examine the impact of volleyball training on the physical fitness and mental health of college students in this context. Physical activity and sports have been shown to have numerous benefits for both physical and mental health. The purpose of this study is to examine the impact of volleyball classes on the physical fitness and health outcomes of college students.
Materials and Methods. Ten third-year college students participated in the study, all of whom agreed to participate voluntarily. Over a period of three months, the students attended volleyball classes. The following tests were used to measure physical fitness: Shuttle run 3×10 meters (seconds), Running 60 meters (seconds), Jumping up (centimeters), and Jumping over a rope in 30 seconds. Data were analyzed using SPSS software.
Results: A comparison of the results at the beginning and end of the study showed significant changes in jumping up and jumping over a rope in 30 seconds (p<0.001). The results of the other tests also showed improvement.
Conclusions. The results of this study suggest that volleyball classes had a positive effect on the physical fitness of college students. Specifically, the classes contributed to improvements in all of the tests used to measure physical fitness. Therefore, volleyball classes may be an effective means of promoting physical activity and improving the physical fitness and health outcomes of college students. However, it is recommended that colleges prioritize the safety and well-being of their students above all else by continuing to offer online classes and minimizing in-person gatherings, including sports activities, as much as possible.
The Estimating of the Conditional Density with Application to the Mode Function in Scalar-On-Function Regression Structure: Local Linear Approach with Missing at Random
Authors: Bouabsa Wahiba
Published: May 2023

The aim of this research was to study a nonparametric estimator of the density and mode function of a scalar response variable given a functional variable, when the observations are i.i.d. This proposed estimator is given by combining Missing At Random (MAR) with the local linear approach. Finally, a comparison study based on simulated data is also provided to illustrate the finite sample performances and the usefulness of the local linear approach with MAR to the presence of even a small proportion of outliers in the data.