bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study of Teachers’ Self-Efficacy Beliefs, Motivation to Teach, and Curriculum Fidelity: A Path Analysis Model
Authors: AYTAÇ Alper
Published: November 2021

The aim of this study is to test a path analysis model that examines teachers’ self-efficacy beliefs, motivation to teach, and curriculum fidelity. A correlational survey model was used while designing the study. The study sample consisted of 414 teachers working in a province of Turkey during the spring semester of the 2019-2020 academic year. The Teacher Self-Efficacy Beliefs Scale, the Teachers’ Motivation to Teach Scale, and the Curriculum Fidelity Scale were all used as data collection tools. Prior to data analysis, the data set was tested for both univariate and multivariate normality; descriptive statistics, Pearson’s correlation, and path analysis were also used to test the data. Results gathered from the study show that teachers have strong self-efficacy beliefs; while they had a high level of intrinsic motivation, their extrinsic motivation was found to be at a moderate level. Based on the results of the path analysis, teachers’ self-efficacy beliefs were found to directly and indirectly predict both their motivation to teach and their curriculum fidelity. In addition, teachers’ levels of intrinsic motivation were found to predict curriculum fidelity directly, while their levels of extrinsic motivation were found to affect curriculum fidelity indirectly.
Comparison of PISA and PIAAC Participants’ Reading Habits and Strategies in Terms of Reading Achievement
Authors: YALÇIN Seher , BAYRAKTAR Ayşegül
Published: November 2021

The aim of this study was to compare reading strategies and habits in terms of reading achievement of select age-group participants from the Programme for International Student Assessment (PISA) 2009 and the International Assessment of Adult Competencies (PIAAC) 2015 within Turkey. A cohort design was utilised because it was assumed that reading literacy from PISA and PIAAC were comparable as well as that participants from PISA 2009 would be in the age range of participants at the time of PIAAC in 2015. The participant population selected from PISA 2009 for the current study consisted of 4719 Turkish students (2334 girls, 2385 boys) aged 15 years-old, while those chosen from PIAAC 2015 consisted of 308 Turkish individuals (141 men, 167 women) aged 20-22 years-old. Data analysis was conducted through latent class analysis based on participants’ gender, the number of books in the home, and reading achievement. Results revealed that female participants were more successful than male participants in PISA, whereas male participants outperformed female participants in PIAAC.
Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Authors: Tarantino Paolo , Carmagnani Pestana Roberto , Corti Chiara , Modi Shanu , Bardia Aditya , Tolaney Sara M. , Cortes Javier , Soria Jean‐Charles , Curigliano Giuseppe
Published: November 2021

As distinct cancer biomarkers have been discovered in recent years, a need to reclassify tumors by more than their histology has been proposed, and therapies are now tailored to treat cancers based on specific molecular aberrations and immunologic markers. In fact, multiple histology‐agnostic therapies are currently adopted in clinical practice for treating patients regardless of their tumor site of origin. In parallel with this new model for drug development, in the past few years, several novel antibody–drug conjugates (ADCs) have been approved to treat solid tumors, benefiting from engineering improvements in the conjugation process and the introduction of novel linkers and payloads. With the recognition that numerous surface targets are expressed across various cancer histologies, alongside the remarkable activity of modern ADCs, this drug class has been increasingly evaluated as suitable for a histology‐agnostic expansion of indication. For illustration, the anti‐HER2 ADC trastuzumab deruxtecan has demonstrated compelling activity in HER2‐overexpressing breast, gastric, colorectal, and lung cancer. Examples of additional novel and potentially histology‐agnostic ADC targets include trophoblast cell‐surface antigen 2 (Trop‐2) and nectin‐4, among others. In the current review article, the authors summarize the current approvals of ADCs by the US Food and Drug Administration focusing on solid tumors and discuss the challenges and opportunities posed by the multihistological expansion of ADCs.
Composição corporal e índice de massa corporal de mulheres praticantes de Pilates de duas cidades gaúchas
Authors: Mathucheski Bruna , Reis Susiane , Bulso Junior Orlando , Rodrigues Pinto Francine , Dias Arieli Fernandes , Gaya Anelise Reis , Haas Aline Nogueira
Published: November 2021

Introdução: O Método Pilates (MP) se desenvolveu muito nos últimos anos, fazendo-se necessário compreender seus efeitos na composição corporal de seus praticantes. Objetivo: Avaliar e comparar o Índice de Massa Corporal (IMC) e a composição corporal de mulheres praticantes do MP de duas cidades do Estado do Rio Grande do Sul. Métodos: Foram avaliadas 30 mulheres praticantes do MP contemporâneo há pelo menos três meses, com frequência de uma ou duas vezes por semana, com idade média 40,50 ± 10,94 anos, sendo 15 delas em Encruzilhada do Sul (GE), e as outras 15, em Viamão (GV). Foram aferidas seis dobras cutâneas, seis perímetros, nove diâmetros e nove comprimentos, além de peso e altura para obter o IMC. Foi realizada estatística descritiva e teste t para amostras independentes, adotando nível de significância de p < 0,05. Resultados: Não foram encontradas diferenças estatísticas significativa entre os grupos na composição corporal e no IMC. Ocorreu diferença estatística significativa entre os dois grupos com relação ao tempo de prática (p = 0,01). Conclusão: Conclui-se que os grupos apresentam composição corporal e IMC semelhantes. Porém, evidencia-se uma tendência a maiores níveis de gordura corporal e índices de obesidade no GV, devido ao menor tempo de prática do MP.
Análise dos marcos do desenvolvimento em prematuros utilizando a Escala Bayley
Authors: Souza dos Santos Ligiane , Soria Lilian Cristina Munhoz , Santos Janaina Senhorini dos , Antoniucci Juliana Marinho , Rodrigues Olga Maria Piazentin Rolim
Published: November 2021

Prematuros apresentam risco aumentado para atrasos na aquisição de habilidades neuromotoras.  Os marcos do desenvolvimento preconizam que um bebê a termo de seis meses seja capaz de manter-se sentado com apoio, aos nove meses se locomova utilizando o movimento de engatinhar e, aos 12 meses, troque passos com apoio. Esse estudo pretendeu analisar o desenvolvimento motor grosseiro de bebês nascidos pré termo quanto a aquisição das habilidades do sentar, engatinhar e andar, utilizando os escores da Escala Bayley-III, aplicada aos seis, nove e 12 meses em participantes de um programa de intervenção precoce, relacionando-as ao sexo e idade gestacional. Observou-se que dos 129 participantes, 37,21% dos bebês sentaram com apoio por 30 segundos aos seis meses. Quanto a série engatinhar, avaliada aos nove meses, 27,91% dos bebês apresentaram o movimento nesta idade. Aos 12 meses, a maioria dos participantes (82,17%) apresentou o andar com apoio, o esperado para a idade. Considerando sexo e idade gestacional,
observou-se que quanto menos semanas gestacionais menos bebês alcançaram as metas para a idade/mês e essa ocorrência é mais frequente em meninos.
Efeitos de um programa de condicionamento físico no equilíbrio e funcionalidade da marcha em indivíduos pós acidente vascular cerebral
Authors: Asa Sabrina Kyoko de Paula , Oliveira Elaine Menezes de , Matuti Gabriela da Silva , Oliveira Clarissa Barros de
Published: November 2021

O Acidente Vascular Cerebral (AVC) pode gerar diminuição do nível de atividade física, força muscular e capacidade aeróbica e com isso levar à redução da velocidade e à qualidade da marcha. O presente estudo teve como objetivo investigar os efeitos que exercícios aeróbios associados ao fortalecimento de membros inferiores podem ter sobre o equilíbrio e a funcionalidade da marcha em indivíduos que sofreram AVC. Foram avaliados indivíduos submetidos a um protocolo de condicionamento físico na Associação de Assistência à Criança Deficiente (AACD). Foram observadas mudanças em todas as variáveis analisadas (Teste de caminhada de 6 minutos, Teste de caminhada de 10 metros, Timed Up and Go e Mini BEST-test) após o término do protocolo e 3 meses de follow-up. A melhora encontrada no mini BEST-test foi estatisticamente significante. O protocolo de condicionamento físico realizado promoveu melhora no desempenho da marcha e influência significativa no equilíbrio dos indivíduos estudados.
Ocorrência de quedas e oferta de atividade física em instituições de longa permanência para idosos no Distrito Federal, Brasil
Authors: Santana Érica Merces Macêdo de , Safons Marisete Peralta
Published: November 2021

Introdução: O envelhecimento é um processo natural que provoca declínios na saúde. Residentes em instituições de longa permanência para idosos (ILPI) apresentam maiores índices de quedas que os idosos da comunidade, necessitando de maior atenção. Objetivo: Descrever a ocorrência de quedas em idosos institucionalizados e a oferta de atividade física disponível dentro das ILPI do Distrito Federal, Brasil. Métodos: Estudo transversal, descritivo, exploratório, de abordagem quantitativa, tendo como cenário as ILPI do Distrito Federal. Variáveis descritivas foram organizadas em planilha de Excel®, a análise dos dados foi feita através de frequência absoluta e relativa. Resultados: Dez ILPI participaram do estudo, sendo estas de caráter privado, filantrópica e mista, podendo ter imóvel próprio ou alugado. A maioria dos residentes são do sexo feminino, e a faixa etária foi de 60 a 104 anos entre os idosos. Todas as ILPI possuíam oferta de atividade física e a incidência de quedas esteve entre 0% e 27,27% no ano de 2017 nas instituições pesquisadas. Conclusão: Em todas as instituições, o fisioterapeuta era profissional responsável pela oferta de atividades físicas, considerando que este profissional tem formação para prescrever atividades voltadas a reabilitação físico funcional. Maiores estudos precisam ser conduzidos sobre esse tema para a realização de futuras intervenções com este público.
Influência do protagonismo do paciente no tratamento fisioterapêutico da dor crônica na coluna vertebral
Authors: Melz Bruna Maria , Jaeger Lydia Koetz , Grave Magali Teresinha Quevedo
Published: November 2021

Este estudo buscou descrever o perfil sociodemográfico de pacientes de fisioterapia com dor crônica (DC) na coluna vertebral (CV) e a relação psicossocial com o protagonismo após a realização de exercícios físicos. Estudo exploratório-descritivo, de intervenção, com análise quantitativa dos dados, realizado na Clínica Escola de Fisioterapia (CEF) da Universidade do Vale do Taquari - Univates, Lajeado, RS. A coleta de dados se deu por questionário de identificação e os protocolos Start Back Screening Tool (SBST), Fear Avoidance Belief Questionnaire (FABQ), Questionário de Qualidade de Vida SF-36 e Índice Oswestry de Incapacidade (IOI). Participaram nove pacientes com DC na CV, sendo alocados em grupos: intervenção, participou de um grupo de promoção à saúde durante quatro semanas, duas vezes na semana, para a realização de exercícios na CEF; controle, recebeu cartilha com os mesmos exercícios para serem realizados no domicílio pelo mesmo período. Ambos os grupos apresentaram melhora no SF-36, SBST e IOI. No FABQ, apresentaram melhora no item atividade física e piora no trabalho. Conclui-se que o programa de exercícios utilizado em pacientes que apresentam DC na CV é positivo na melhora do prognóstico e qualidade de vida; redução de incapacidades e crenças. Ainda, exercícios domiciliares incentivam o protagonismo dos pacientes.
NOVO CORONAVÍRUS (COVID-19) E A AGRICULTURA FAMILIAR NO LITORAL DO PARANÁ:
Authors: Anacleto Adilson , Frare Emmanuel Lehn , Neves João Vitor Batista das
Published: November 2021

Visando subsidiar uma melhor compreensão do cenário atual da crise instalada pelo Novo Coronavírus no campo, apresenta-se o resultado de uma pesquisa exploratória descritiva junto a 21 pequenos produtores rurais no litoral do Paraná. Os resultados evidenciaram que a pandemia gerou uma redução na renda familiar na ordem de 63,4%. O temor pelo futuro gerou implicações psicológicas, tendo sido registrados quadros marcados pelo medo, tensão e desconfiança, porém não houve evolução para quadros depressivos. A provável explicação para essa situação pode residir no fato de que as famílias mantiveram suas atividades laborais, o que pode ter contribuído para o combate aos efeitos psicológicos. Ademais, as novas tecnologias e redes sociais se apresentaram como as principais formas de atingir o distante consumidor, tendo as novas gerações assumido um papel comercial nas vendas, sendo essas medidas apontadas como a principal ação de enfrentamento à pandemia. A partir desse contexto, urge que seja pensado pelos produtores rurais o fortalecimento da classe, o que pode conferir maior poder de barganha, e que se façam ter visibilidade, visto que essa é uma situação ainda não percebida pelo poder público nesse período de pandemia causado pelo Novo Coronavírus.
Impacto del control ciudadano en el cumplimiento normativo de los portales de transparencia estándar en empresas de saneamiento del sur del Perú
Authors: Calderón Paniagua Dennys Geovanni , Quispe Vilca Grisely Rosalie , Paniagua Quispe Braulia , Flores Choquecota Hugo
Published: November 2021

La investigación tuvo como objetivo principal, analizar el impacto del control ciudadano en el cumplimiento normativo de los portales de transparencia estándar (PTE) de las empresas de saneamiento del sur del Perú. Respecto al tipo de investigación, se encuentra enmarcada en el tipo básica, sobre el diseño de investigación, fue de nivel descriptivo, toda vez que tiene la finalidad de generar nuevos conocimientos, al evaluar el impacto que se genera en el nivel de cumplimiento de las normas aplicables en los PTE de las empresas de saneamiento de las regiones ubicadas en el sur del Perú mediante la aplicación del control ciudadano, dentro de las normas legales de acceso a la información pública y control social, lo cual fortalece la participación ciudadana. La población y muestra estuvo constituida por las 4 empresas de saneamiento ubicadas en las regiones sur del territorio peruano, específicamente en las regiones de Arequipa, Moquegua y Tacna, asimismo, se empleó un análisis registral. Se concluye que el impacto generado luego de la aplicación del control ciudadano en la verificación del nivel de cumplimiento normativo de los PTE en las empresas de saneamiento del sur del Perú fue de un porcentaje de cumplimiento al 30.5 % categorizado con la calificación de “necesitan mejorar”, este resultado evidencia el bajo nivel de cumplimiento normativo y demuestra la deficiente transparencia de información pública que tienen dichas empresas hacia la población.
A Study on Strongly Almost Convergent and Strongly Almost Null Binomial Double Sequence Spaces
Authors: ERDEM Sezer , DEMİRİZ Serkan
Published: November 2021

The 4 dimensional (4d) binomial matrix and its domains on the classical double sequence spaces $\mathcal{L}_{p}$, $\mathcal{M}_{u}$, $\mathcal{C}_{P}$, $\mathcal{C}_{bP}$, $\mathcal{C}_{r}$, $\mathcal{C}_{f}$ and $\mathcal{C}_{f_0}$ have been described and examined by Demiriz and Erdem in the papers \cite{e.d.2}-\cite{e.d.3}. In this article, we describe two double sequence spaces with the aid of the aforementioned matrix and study some properties of these. After giving inclusion relations, we compute $\alpha-$, $\beta(bp)-$ and $\gamma-$duals and give some new matrix classes related them.
FEASIBILITY STUDY OF ORNAMENTAL PLANT BUSINESS IN COVID PANDEMIC AT BATURAJA OKU SOUTH SUMATERA
Authors: Sari Fifian Permata , Munajat Munajat
Published: November 2021

The ornamental plant business is a very profitable and promising venture, made even more so by the fact that there is an ornamental plant trend at the start of 2019. Certain types of ornamental plants can be quite expensive, and some customers are willing to pay a premium for them to add to their ornamental plant collection. As a result, the number of florists has increased, particularly in Baturaja City. During the Covid-19 pandemic, numerous businesses, including ornamental plant businesses, suffered financial losses. Some businesses have been unable to survive due to losses as a result of people's limited purchasing power for ornamental plants. The goal of this research is to determine the viability of the ornamental plant business in Baturaja, especially in the event of a pandemic. In this study, the census method was used, and the saturated sampling method was used for sampling. The analysis was carried out using a feasibility analysis with R/C ratio analysis. In Baturaja, data was gathered from 15 ornamental plant business actors. With an R/C of 1.65, the study's findings indicated that the ornamental plant business in the city of Baturaja would be viable in the event of a pandemic. 

Keywords: Feasibility study, ornamental plant business, pandemic Covid

 

Abstrak

Bisnis tanaman hias merupakan bisnis yang sangat menjanjikan dan menguntungkan, apalagi setelah terjadi trend tanaman hias di awal tahun 2019. Beberapa jenis tanaman hias dapat dijual dengan harga yang tinggi dan konsumen mau membeli dengan harga tinggi tersebut, untuk menambah koleksi. Fenomena ini juga terjadi di kota Baturaja. Selama pandemi Covid-19, banyak bisnis yang merugi, termasuk bisnis tanaman hias. Turun nya daya beli masyarakat juga berpengaruh terhadap bisnis tanaman hias. Membuat para pelaku usaha bisnis ini tidak mampu bertahan karena merugi. Penelitian ini bertujuan untuk menganalisis kelayakan usaha tanaman hias di kota Baturaja khususnya pada masa pandemi Covid-19. Metode yang digunakan dalam penelitian ini adalah metode sensus dan metode penarikan contoh yang digunakan adalah metode acak jenuh.  Metode analisis yang digunakan dalam pengolahan data penelitian adalah analisis kelayakan menggunakan R/C ratio. Sedangkan data yang dikumpulkan berasal dari 15 pelaku usaha tanaman hias di kota Baturaja.  Hasil penelitian menunjukkan bahwa usaha tanaman hias di kota Baturaja di masa pandemic Covid masih layak untuk terus diusahakan dengan nilai R/C sebesar 1.65.

Kata kunci: Analisis kelayakan, bisnis tanaman hias, pandemic Covid
THE ROLE OF BUSINESS TRUST, CONSUMER CONFIDENCE AND THE DEVELOPMENT OF INFORMATION AND COMMUNICATION TECHNOLOGY ON ECONOMIC GROWTH IN G20 COUNTRIES
Authors: Syahputra Hardiansa Nur , Marselina Marselina , Aida Neli
Published: November 2021

This study aims to analyze the condition of business trust, consumer trust, rule of law, developments in technology,information, and communication, and their influence on ASEAN economic growth. The data used is panel dataconsisting of time series data for 2009 – 2020 and a cross-section of 10 countries with the highest level of businessconfidence in G20 Member countries. The variables used are economic growth, conditions of business trust,consumer confidence, rule of law, development of technology, information, and communication. The analyticaltool used is panel data regression, namely the Fixed Effect Model (FEM). An increase in business confidence andconsumer confidence will have an impact on increasing economic growth. In the research results, business trust has the most influence.

Keywords: Economic Growth, Conditions of Business Trust, and Consumer Confidence.

 

Abstrak

Penelitian ini bertujuan untuk menganalisis kondisi kepercayaan bisnis, kepercayaan konsumen, supremasi hukum, perkembangan teknologi, informasi, dan komunikasi, serta pengaruhnya terhadap pertumbuhan ekonomi ASEAN. Data yang digunakan adalah data panel yang terdiri dari data time series tahun 2009 – 2020 dan cross section dari 10 negara dengan tingkat kepercayaan bisnis tertinggi di negara-negara Anggota G20. Variabel yang digunakan adalah pertumbuhan ekonomi, kondisi kepercayaan bisnis, kepercayaan konsumen, supremasi hukum, perkembangan teknologi, informasi, dan komunikasi. Alat analisis yang digunakan adalah regresi data panel yaitu Fixed Effect Model (FEM). Meningkatnya kepercayaan bisnis dan kepercayaan konsumen akan berdampak pada peningkatan pertumbuhan ekonomi. Dalam hasil penelitian, kepercayaan bisnis memiliki pengaruh paling besar.

Kata Kunci: Pertumbuhan Ekonomi, Kepercayaan Bisnis, dan Kepercayaan Konsumen.
NON-TAX STATE REVENUE (PNBP) IN PUBLIC WATER FISHERIES RESEARCH CENTERS AND FISHERIES EXPLANATION (BRPPUPP)
Authors: Putri Tike Dwi
Published: November 2021

This study aims to analyze Non-Tax State Revenue (PNBP) at the Public Water Fisheries Research Institute and Fisheries Extension (BRPPUPP) Tax in terms of recording accuracy, management compliance, and effectiveness. then analyzed using descriptive qualitative analysis method. The results of this study indicate that the percentage of PNBP for the Public Water Fisheries Research Center and Fisheries Extension in 2019 the realization of PNBP receipts does not reach the target which shows that the performance of achieving the target is 89.5%, while the amount of revenue in 2020 illustrates the effectiveness of the PNBP policy exceeding the target of 198.9 %.

Keywords: PNBP, BRPPUPP

 

Abstrak

Penelitian ini bertujuan untuk menganalisa Penerimaan Negara Bukan Pajak (PNBP) di Balai Riset Perikanan Perairan Umum dan Penyuluhan Perikanan (BRPPUPP) Pajak yang ditinjau dari sisi keakuratan pencatatan, kepatuhan pengelolaan, serta tingkat keefektifan. kemudian dianalisis dengan menggunakan Metode analisis deskriptif kualitatif. Hasil penelitian ini menjukan bahwa persentase PNBP untuk di Balai Riset Perikanan Perairan Umum dan Penyuluhan Perikanan di tahun 2019 realisasi penerimaan PNBP tidak mencapai target yang menunjukan bahwa kinerja pencapaian target sebesar  89.5%, Sedangkan jumlah penerimaan pada tahun 2020 menggambarkan keefektifan kebijakan PNBP  melebihi target sebesar 198.9%.

Kata kunci: PNBP,BRPPUPP
NORMALIZATION OF THE METABOLISM OF ESSENTIAL FATTY ACIDS OF PHOSOLIPIDS OF THE LIVER OF RATS RECEIVED WITH PALM OIL ON THE BACKGROUND OF DISBIOSIS BY THE PHYTOPREPARATION “KVERTULIN”
Authors:   Odessa National Academy of Food Technologies, Levitsky A. P. , Markov A. V. ,   Lviv National Medical University named after Danylo Halytsky, Pupin T. I. ,   Lviv National Medical University named after Danylo Halytsky, Zubachik V. M. ,   Lviv National Medical University named after Danylo Halytsky
Published: November 2021

Keywords: liver, phospholipids, essential fatty acids, palm oil, dysbiosis, herbal medicine. Aim. To study the effect of the phytopreparation kvertulin on the processes of biosynthesis of PUFA of liver phospholipids in rats treated with palm oil against the background of dysbiosis. Methods. Rats consumed a fat-free diet (group 1), a diet with 15 % palm oil (group 2), a diet with 15 % palm oil on the background of experimental dysbiosis (group 3) and a diet with 15 % palm oil on background of dysbiosis + kvertulin. The duration of the experiment is 40 days. The content of fatty acids in liver phospholipids was determined by gas chromatography. The ratio of the PUFA content was used to calculate the “activity” of ω-3-desaturase, the intensity of synthesis of arachidonic acid, and the intensity of synthesis of docosahexaenoic acid. Results: In rats of the 3rd group, which received palm oil against the background of dysbiosis, there was a decrease in the content of ω-3 PUFA, an increase in the ratio of ω-6 / ω-3 PUFA, and a decrease in the “activity” of ω-3-desaturase. In rats of the 4th group, which received kvertulin, the content of PUFA was completely restored and the “activity” of enzymes of their biosynthesis was normalized. Conclusion. The use of the phytopreparation kvertulin normalizes the endogenous biosynthesis of PUFA of liver phospholipids in rats consuming palm oil against the background of dysbiosis.
No One in Control? China's Battler Poetry
Authors: Van Crevel Maghiel
Published: November 2021

No literary genre is fully predictable or controllable – but some are more unpredictable and uncontrollable than others, and China's battler poetry is a case in point. In China, up to three hundred million people have left the countryside to flee from poverty and make their way into city life. Exposed to the extreme dynamic of global capitalism, these ‘battlers’ are the foot soldiers of China's economic rise but not invariably its beneficiaries. Many live and work under gruelling conditions and are deprived of basic civil rights, as second-class citizens in socio-economic and cultural terms. And… they write poetry. Not all of them by any means, but enough for a phenomenon called ‘battler poetry’ to enter the public eye. What is battler poetry, and what does it do? What happens when dominant logics of ideology, literary aesthetics and cultural expectations encounter the circumstances of battler life? The force field around this poetry is dizzyingly complex and rife with opportunities for disconnect and the unexpected, throwing into sharp relief the randomness that is part and parcel of cultural production.
The Ontopolitics of Mountain Bike Trail Building: Addressing Issues of Access and Conflict in the More-than Human English Countryside
Authors: Cherrington Jim
Published: November 2021

In recent years there have been calls for scholars working within sport and physical culture to recognise the (increasing) confluence of nature and culture. Situated within an emerging body of new materialist research, such accounts have shown how various activities are polluted by, fused to, and assembled with non-human entities. However, more work is needed on the political possibilities afforded by non-human agency, and by extension, the implications that such flat ontological arrangements might raise for the management and governance of physical culture. Building on research conducted with mountain bike trail builders, this article seeks to explore what it means to know, to be, and to govern a human subject in the Anthropocene. Specifically, I draw on James Ash’s (2019) post-phenomenological theory of space and David Chandler’s (2018) notion of onto-political hacking to show how the playful, contingent, and transformative practices of the mountain bike assemblage confront the linear and calculated governance of the English countryside. In doing so, mountain bike trails are positioned as objects of hope that allow for a collective re-imagining of political democracy in a more-than-human landscape.
‘We are Not a Nation of Softies, But We Could Become One’: Exploring the Materiality of Fitness Testing in the President's Council on Youth Fitness
Authors: Esmonde Katelyn , Jette Shannon
Published: November 2021

In this article, we peer into the scientific networks of humans and non-humans that were assembled to articulate youth fitness in the United States during the Cold War era when the perceived ‘muscle gap’ between United States youth and their European and Soviet counterparts lent urgency to the establishment of national fitness testing standards and plans. We draw on Actor-Network Theory as a theory/method to foreground the materiality of the body and measurement tools whilst also highlighting the contingency of scientific claims about the body and fitness. In particular, we discuss and contextualise two interrelated networks of fitness testing. First, we examine the Kraus-Weber Tests for Minimum Muscular Fitness in Children (K-W tests), whose results were published in 1953 and brought the ‘muscle gap’ to national attention. Second, we explore the networks assembled within the President's Council on Youth Fitness in order to implement fitness testing on a national scale, illustrating how they connected to, and extended, a variety of other networks, including the K-W tests. Throughout our analysis, we seek to illuminate the political implications of the technical work undertaken to articulate youth ‘fitness’.
Mitochondria-Targeted Nanocarriers Promote Highly Efficient Cancer Therapy: A Review
Authors: Zeng Zeng , Fang Chao , Zhang Ying , Chen Cong-Xian , Zhang Yi-Feng , Zhang Kun
Published: November 2021

Mitochondria are the primary organelles which can produce adenosine triphosphate (ATP). They play vital roles in maintaining normal functions. They also regulated apoptotic pathways of cancer cells. Given that, designing therapeutic agents that precisely target mitochondria is of great importance for cancer treatment. Nanocarriers can combine the mitochondria with other therapeutic modalities in cancer treatment, thus showing great potential to cancer therapy in the past few years. Herein, we summarized lipophilic cation- and peptide-based nanosystems for mitochondria targeting. This review described how mitochondria-targeted nanocarriers promoted highly efficient cancer treatment in photodynamic therapy (PDT), chemotherapy, combined immunotherapy, and sonodynamic therapy (SDT). We further discussed mitochondria-targeted nanocarriers’ major challenges and future prospects in clinical cancer treatment.
Dynamic Expression and Regulatory Network of Circular RNA for Abdominal Preadipocytes Differentiation in Chicken (Gallus gallus)
Authors: Tian Weihua , Zhang Bo , Zhong Haian , Nie Ruixue , Ling Yao , Zhang Hao , Wu Changxin
Published: November 2021

Circular RNA (circRNA), as a novel endogenous biomolecule, has been emergingly demonstrated to play crucial roles in mammalian lipid metabolism and obesity. However, little is known about their genome-wide identification, expression profile, and function in chicken adipogenesis. In present study, the adipogenic differentiation of chicken abdominal preadipocyte was successfully induced, and the regulatory functional circRNAs in chicken adipogenesis were identified from abdominal adipocytes at different differentiation stages using Ribo-Zero RNA-seq. A total of 1,068 circRNA candidates were identified and mostly derived from exons. Of these, 111 differentially expressed circRNAs (DE-circRNAs) were detected, characterized by stage-specific expression, and enriched in several lipid-related pathways, such as Hippo signaling pathway, mTOR signaling pathway. Through weighted gene co-expression network analyses (WGCNA) and K-means clustering analyses, two DE-circRNAs, Z:35565770|35568133 and Z:54674624|54755962, were identified as candidate regulatory circRNAs in chicken adipogenic differentiation. Z:35565770|35568133 might compete splicing with its parental gene, ABHD17B, owing to its strictly negative co-expression. We also constructed competing endogenous RNA (ceRNA) network based on DE-circRNA, DE-miRNA, DE-mRNAs, revealing that Z:54674624|54755962 might function as a ceRNA to regulate chicken adipogenic differentiation through the gga-miR-1635-AHR2/IRF1/MGAT3/ABCA1/AADAC and/or the novel_miR_232-STAT5A axis. Translation activity analysis showed that Z:35565770|35568133 and Z:54674624|54755962 have no protein-coding potential. These findings provide valuable evidence for a better understanding of the specific functions and molecular mechanisms of circRNAs underlying avian adipogenesis.
Epigenetic Repression of Chloride Channel Accessory 2 Transcription in Cardiac Fibroblast: Implication in Cardiac Fibrosis
Authors: Shao Tinghui , Xue Yujia , Fang Mingming
Published: November 2021

Cardiac fibrosis is a key pathophysiological process that contributes to heart failure. Cardiac resident fibroblasts, exposed to various stimuli, are able to trans-differentiate into myofibroblasts and mediate the pro-fibrogenic response in the heart. The present study aims to investigate the mechanism whereby transcription of chloride channel accessory 2 (Clca2) is regulated in cardiac fibroblast and its potential implication in fibroblast-myofibroblast transition (FMyT). We report that Clca2 expression was down-regulated in activated cardiac fibroblasts (myofibroblasts) compared to quiescent cardiac fibroblasts in two different animal models of cardiac fibrosis. Clca2 expression was also down-regulated by TGF-β, a potent inducer of FMyT. TGF-β repressed Clca2 expression at the transcriptional level likely via the E-box element between −516 and −224 of the Clca2 promoter. Further analysis revealed that Twist1 bound directly to the E-box element whereas Twist1 depletion abrogated TGF-β induced Clca2 trans-repression. Twist1-mediated Clca2 repression was accompanied by erasure of histone H3/H4 acetylation from the Clca2 promoter. Mechanistically Twist1 interacted with HDAC1 and recruited HDAC1 to the Clca2 promoter to repress Clca2 transcription. Finally, it was observed that Clca2 over-expression attenuated whereas Clca2 knockdown enhanced FMyT. In conclusion, our data demonstrate that a Twist1-HDAC1 complex represses Clca2 transcription in cardiac fibroblasts, which may contribute to FMyT and cardiac fibrosis.
Regulated Cell Death in Urinary Malignancies
Authors: Nie Zhenyu , Chen Mei , Gao Yuanhui , Huang Denggao , Cao Hui , Peng Yanling , Guo Na , Zhang Shufang
Published: November 2021

Urinary malignancies refer to a series of malignant tumors that occur in the urinary system and mainly include kidney, bladder, and prostate cancers. Although local or systemic radiotherapy and chemotherapy, immunotherapy, castration therapy and other methods have been applied to treat these diseases, their high recurrence and metastasis rate remain problems for patients. With in-depth research on the pathogenesis of urinary malignant tumors, this work suggests that regulatory cell death (RCD) plays an important role in their occurrence and development. These RCD pathways are stimulated by various internal and external environmental factors and can induce cell death or permit cell survival under the control of various signal molecules, thereby affecting tumor progression or therapeutic efficacy. Among the previously reported RCD methods, necroptosis, pyroptosis, ferroptosis, and neutrophil extracellular traps (NETs) have attracted research attention. These modes transmit death signals through signal molecules, such as cysteine-aspartic proteases (caspase) family and tumor necrosis factor-α (TNF-α) that have a wide and profound influence on tumor proliferation or death and even change the sensitivity of tumor cells to therapy. This review discussed the effects of necroptosis, pyroptosis, ferroptosis, and NETs on kidney, bladder and prostate cancer and summarized the latest research and achievements in these fields. Future directions and possibility of improving the denouement of urinary system tumors treatment by targeting RCD therapy were also explored.
CircCRIM1 Promotes Hepatocellular Carcinoma Proliferation and Angiogenesis by Sponging miR-378a-3p and Regulating SKP2 Expression
Authors: Ji Yang , Yang Shikun , Yan Xueqi , Zhu Li , Yang Wenjie , Yang Xinchen , Yu Fei , Shi Longqing , Zhu Xi , Lu Yunjie , Zhang Chuanyong , Lu Hao , Zhang Feng
Published: November 2021

Mounting evidence has demonstrated that circular RNAs have an important function in tumorigenesis and cancer evolvement. CircCRIM1 has been shown to be a poor prognostic element in multiple human malignancies. However, the clinical significance and mechanism of circCRIM1 in hepatocellular carcinoma (HCC) is still unclear. The present study confirmed the expression level of circCRIM1 using quantitative real-time PCR. In addition, circCRIM1 siRNA and overexpression vectors were used for transfection into LM3 or Huh7 cells to down- or up-regulate the expression of circCRIM1. In vitro and in vivo experiments were performed to explore the function of circCRIM1 in HCC. RNA pull-down, RNA immunoprecipitation, fluorescent in situ hybridization, and luciferase reporter assays were conducted to confirm the relationship between miR-378a-3p and circCRIM1 or S-phase kinase-associated protein 2 (SKP2) in HCC. Then, circCRIM1 was up-regulated in HCC and its expression level was significantly associated with poor prognosis and clinicopathologic characteristics. CircCRIM1 enhanced the proliferation and angiogenesis of HCC cells in vitro and promoted xenograft growth in vivo. Moreover, circCRIM1 upregulated the expression of SKP2 by functioning as a sponge for miR-378a-3p. These findings suggest that circCRIM1 boosts the HCC progression via the miR-378-3p/SKP2 axis and may act as a crucial epigenetic therapeutic molecule target in HCC.
Ab Initio Calculations for the Electronic, Interfacial and Optical Properties of Two-Dimensional AlN/Zr2CO2 Heterostructure
Authors: Ren Kai , Zheng Ruxin , Lou Junbin , Yu Jin , Sun Qingyun , Li Jianping
Published: November 2021

Recently, expanding the applications of two-dimensional (2D) materials by constructing van der Waals (vdW) heterostructures has become very popular. In this work, the structural, electronic and optical absorption performances of the heterostructure based on AlN and Zr2CO2 monolayers are studied by first-principles simulation. It is found that AlN/Zr2CO2 heterostructure is a semiconductor with a band gap of 1.790 eV. In the meanwhile, a type-I band structure is constructed in AlN/Zr2CO2 heterostructure, which can provide a potential application of light emitting devices. The electron transfer between AlN and Zr2CO2 monolayer is calculated as 0.1603 |e| in the heterostructure, and the potential of AlN/Zr2CO2 heterostructure decreased by 0.663 eV from AlN layer to Zr2CO2 layer. Beisdes, the AlN/Zr2CO2 vdW heterostructure possesses excellent light absorption ability of in visible light region. Our research provides a theoretical guidance for the designing of advanced functional heterostructures.
The Ratio of NT-proBNP to CysC1.53 Predicts Heart Failure in Patients With Chronic Kidney Disease
Authors: Wang Sheng , Li Ming , Wang Xiangyu , Luo Jing , Zou Yulin , Hu Yang , Liu Xingtai , Ao Hua , Yao Xueer , Li Chufeng , Yang Tingting
Published: November 2021

Background: The N-terminal pro B type natriuretic peptide (NT-proBNP) is important for prognosis of heart failure in patients with chronic kidney disease (CKD). However, the NT-proBNP level is easily affected by renal insufficiency, which limits its clinical use.

Methods: This study included 396 patients with CKD. Plasma levels of NT-proBNP and cystatin C (CysC) were measured during hospitalization. The echocardiographic parameters were also detected. Patients were divided into the heart failure group and control group according to the European Society of Cardiology Guideline on Chronic Heart Failure 2021. Multiple modeling analysis of the values of NT-proBNP and CysC, including NT-proBNP/Cyscn and NT-proBNP/nCysC was performed. The receiver operating characteristic (ROC) curve, combined with the cardiac function, was used to determine the formula with the best diagnostic efficiency. Then, the sensitivity and specificity of new predictors for cardiac insufficiency in CKD patients were calculated. Pearson correlation analysis was used to analyze the relationship between new predictors and the NT-proBNP level. The clinical data of CKD patients from another local hospital were used to validate the new predictors and the cut-off values.

Results: An elevated NT-proBNP/CysC1.53 ratio was an independent risk factor for cardiac dysfunction in CKD and the best predictor derived from multiple modeling analysis. There was no correlation between the NT-proBNP/CysC1.53 ratio and the NT-proBNP level (r = 0.376, p = 6.909). The area under the ROC curve for the NT-proBNP/CysC1.53 ratio was 0.815 (95% confidence interval: 0.772–0.858), and for a cut-off point of 847.964, this ratio had a sensitivity of 78.24%, and a specificity of 69.44%. When applied to the data of CKD patients from another local hospital, the NT-proBNP to CysC1.53 ratio had a sensitivity of 70.27% and a specificity of 67.74%.

Conclusion: The NT-proBNP to CysC1.53 ratio was superior to NT-proBNP alone for predicting cardiac dysfunction in patients with CKD.
ECG Predictors for New-Onset Atrial Fibrillation Within a Year After Radiofrequency Ablation of Counterclockwise-Rotating Atrial Flutter
Authors: Liu Hailei , Gu Zhoushan , Zhu Chao , Li Mingfang , Jiao Jincheng , Chen Hongwu , Yang Gang , Ju Weizhu , Gu Kai , Zhang Fengxiang , Chen Lin Yee , Yang Di , Chen Minglong
Published: November 2021

Background: New-onset atrial fibrillation (AF) after ablation of typical atrial flutter (AFL) is not rare. This study aimed to investigate the predictive value of electrocardiographic parameters on new-onset AF post-typical AFL ablation.

Methods: A total of 158 consecutive patients (79.1% males, mean age 57.8 ± 14.3 years) with typical AFL were enrolled between January 2012 and August 2017 in this single-center study. Patients with a history of AF before ablation were excluded. ECGs during sinus rhythm (SR) and AFL were collected. The duration of the negative component of flutter wave in lead II (DFNII), proportion of the DFNII of the total circle length of AFL (DFNII%), amplitude of the negative component of flutter wave in lead II (AFNII), duration (DPNV1), and amplitude (APNV1) of negative component of the P wave in lead V1, and P wave duration in lead II (DPII) during sinus rhythm were measured.

Results: During a median follow-up of 26.9 ± 11.8 months, 22 cases (13.9%) developed new-onset AF. DFNII was significantly longer in patients with new-onset AF compared to patients without AF (114.7 ± 29.6 ms vs. 82.7 ± 12.8 ms, p < 0.0001). AFNII was significantly lower (0.118 ± 0.034 mV vs. 0.168 ± 0.051 mV, p < 0.0001), DPII (144.21 ± 23.77 ms vs. 111.46 ± 14.19 ms, p < 0.0001), and DPNV1 was significantly longer (81.07 ± 16.87 ms vs. 59.86 ± 14.42 ms, p < 0.0001) in patients with new-onset AF. In the multivariate analysis, DFNII [odds ratio (OR), 1.428; 95% CI, 1.039–1.962; p = 0.028] and DPII (OR, 1.429; 95% CI, 1.046–1.953; p = 0.025) were found to be independently associated with new-onset AF after typical AFL ablation.

Conclusion: Parameters representing left atrial activation time under both the SR and AFL were independently associated with new-onset AF post-typical AFL ablation and may be useful in risk prediction, which needs to be confirmed by further prospective studies.
Underground Hydro-Pumped Energy Storage Using Coal Mine Goafs: System Performance Analysis and a Case Study for China
Authors: Jiang Deyi , Chen Shao , Liu Wenhao , Ren Yiwei , Guo Pengyv , Li Zongze
Published: November 2021

In response to the Paris climate agreement, the Chinese government has taken actions to improve the energy structure by reducing the share of coal-fired thermal power and increasing the use of clean energy. However, due to the extreme shortage of large-scale energy storage facilities, the utilization efficiency of wind and solar power remains low. This paper proposes to use abandoned coal mine goafs serving as large-scale pumped hydro storage (PHS) reservoir. In this paper, suitability of coal mine goafs as PHS underground reservoirs was analyzed with respects to the storage capacity, usable capacity, and ventilation between goaf and outside. The storage capacity is 1.97 × 106 m3 for a typical mining area with an extent of 3 × 5 km2 and a coal seam thickness of 6 m. A typical goaf-PHS system with the energy type αw=0.74 has a performance of 82.8% in the case of annual operation, able to regulate solar-wind energy with an average value of 275 kW. The performance of the proposed goaf-PHS system was analyzed based on the reservoir estimation and meteorological information from a typical region in China. It has been found that using abandoned coal mine goafs to develop PHS plants is technically feasible in wind and solar-rich northwestern and southwestern China.
The Use of Herbal Medicines for the Prevention of Glucocorticoid-Induced Osteoporosis
Authors: Zhang Leiming , Li Xiaoli , Ying Tianhao , Wang Tian , Fu Fenghua
Published: November 2021

Glucocorticoids are drugs that are widely used to suppress inflammation and the activation of the immune system. However, the prolonged use or at high doses of glucocorticoid can result in adverse side effects including osteoporosis, bone loss, and an increased risk of fracture. A number of compounds derived from natural plant sources have been reported to exert anti-inflammatory activity by interacting with the glucocorticoid receptor (GR), likely owing to their chemical similarity to glucocorticoids, or by regulating GR, without a concomitant risk of treatment-related side effects such as osteoporosis. Other herbal compounds can counteract the pathogenic processes underlying glucocorticoid-induced osteoporosis (GIOP) by regulating homeostatic bone metabolic processes. Herein, we systematically searched the PubMed, Embase, and Cochrane library databases to identify articles discussing such compounds published as of May 01, 2021. Compounds reported to exert anti-inflammatory glucocorticoid-like activity without inducing GIOP include escin, ginsenosides, and glycyrrhizic acid, while compounds reported to alleviate GIOP by improving osteoblast function or modulating steroid hormone synthesis include tanshinol and icariin.
Prolactin-Induced Adaptation in Glucose Homeostasis in Mouse Pregnancy Is Mediated by the Pancreas and Not in the Forebrain
Authors: Khant Aung Zin , Kokay Ilona C. , Grattan David R. , Ladyman Sharon R.
Published: November 2021

Adaptive changes in glucose homeostasis during pregnancy require proliferation of insulin-secreting beta-cells in the pancreas, together with increased sensitivity for glucose-stimulated insulin secretion. Increased concentrations of maternal prolactin/placental lactogen contribute to these changes, but the site of action remains uncertain. Use of Cre-lox technology has generated pancreas-specific prolactin receptor (Prlr) knockouts that demonstrate the development of a gestational diabetic like state. However, many Cre-lines for the pancreas also express Cre in the hypothalamus and prolactin could act centrally to modulate glucose homeostasis. The aim of the current study was to examine the relative contribution of prolactin action in the pancreas and brain to these pregnancy-induced adaptations in glucose regulation. Deletion of prolactin receptor (Prlr) from the pancreas using Pdx-cre or Rip-cre led to impaired glucose tolerance and increased non-fasting blood glucose levels during pregnancy. Prlrlox/lox/Pdx-Cre mice also had impaired glucose-stimulated insulin secretion and attenuated pregnancy-induced increase in beta-cell fraction. Varying degrees of Prlr recombination in the hypothalamus with these Cre lines left open the possibility that central actions of prolactin could contribute to the pregnancy-induced changes in glucose homeostasis. Targeted deletion of Prlr specifically from the forebrain, including areas of expression induced by Pdx-Cre and Rip-cre, had no effect on pregnancy-induced adaptations in glucose homeostasis. These data emphasize the pancreas as the direct target of prolactin/placental lactogen action in driving adaptive changes in glucose homeostasis during pregnancy.