bluuebunny/crossref_metadata_2025 huggingface dataset:
Intrahepatic Cholangiocarcinoma With Sarcomatous Transformation: Demonstrating the Transition Zone
Authors: Shimoda Tomonari , Takahashi Kazuhiro , Asayama Kei , Matsuoka Ryota , Oda Tatsuya
Published: September 2024

Intrahepatic cholangiocarcinoma with sarcomatous transformation (ICC-S) is a rare, aggressive neoplasm with epithelial and sarcomatous elements. We report a rapid progression of ICC-S in a 66-year-old woman. Initially, a seemingly benign 8-cm mass was observed. However, the tumor doubled to 16 cm within 3 months during follow-up. Partial hepatectomy confirmed ICC-S and histopathological examination showed cytokeratin 7 and vimentin positivity in epithelial and sarcomatous components, respectively. An analysis of transition zone indicated epithelial–mesenchymal transition as a mechanism for sarcomatous transformation. We provide the first detailed immunohistochemical analysis of the transition zone in ICC-S, highlighting epithelial–mesenchymal transition's role in pathogenesis.
Complications of chronic hypoparathyroidism according to analysis database Russian Registry
Authors: Kovaleva E. V. , Salimkhanov R. K. , Elfimova A. R. , Eremkina A. K. , Pershina-Miliutina A. P. , Bibik E. E. , Gorbacheva A. M. , Vikulova O. K. , Mokrysheva N. G.
Published: September 2024

BACKGROUND. Chronic hypoparathyroidism (HypoPT) is a relatively rare endocrine disorder. Adequate control of the disease requires the prescription of lifelong multicomponent therapy. Lack of sustained compensation of HypoPT is associated with the development of both early and delayed complications, including functional and structural renal pathology, cataracts, cerebral calcification, cardiac rhythm and/or conduction disorders, and others.

AIM. To study the associations of clinical, laboratory and instrumental parameters, as well as the medical therapy, with long-term complications of chronic HypoPT.

MATERIALS AND METHODS. The observational, continuous study was based on the data of the Russian Registry of Patients with Chronic Postoperative and Nonsurgical HypoPT; 1776 patients from 81 regions of the Russian Federation were included in the study.

RESULTS. In the study population, 26,3% of patients (n=467) had at least one of the HypoPT complications, among them nephrolithiasis/nephromicrolithiasis was diagnosed in 33,4%. Nephrocalcinosis was observed in 10,7% and was more often bilateral (93,5%). In 17,4% of patients there was a significant decrease in GFR, corresponding to CKD stages 3a-5. Cataract was present in 34,7% of patients with chronic HypoPT. Statistically significant associations were found for disease duration with impaired renal filtration function (p<0,001), nephrocalcinosis/nephrolithiasis (p=0,001) and cataract (p<0,001). Patients with impaired renal function had higher serum ionized calcium level (p=0,0071) and lower phosphorus level (p=0,002). Cataract was predominantly diagnosed in patients of older age group (p<0,001), predominant in the presence of hypocalcemia by ionized calcium level (p=0,001). In patients undergoing brain MSCT for neurological symptoms, basal ganglia calcifications were detected in more than half of the cases (56,2%). Brain calcification was associated with younger patient age (p<0,001), hyperphosphatemia (p<0,001), hypomagnesemia (p=0,010). Statistically significant associations were observed between calcification of brain structures and higher doses of alfacalcidol and calcium carbonate (p=0,007).

CONCLUSION. The analysis of the database revealed a number of associations between clinical, laboratory and instrumental parameters and long-term complications of HypoPT. The most significant factors in the development of renal pathology and cataracts are the duration of the disease, as well as off-target indicators of calcium-phosphorus metabolism.
Direct Electric System untuk Mengeliminasi Nematoda Radopholus similis pada Medium Tanam Dracaena reflexa
Authors: Indahsari Rizkhi , Supramana Supramana , Munif Abdul , Syafutra Heriyanto
Published: September 2024

Tanaman Song of India (Dracaena reflexa) merupakan komoditas ekspor Indonesia dengan tujuan Jepang, Malaysia, Korea Selatan, Singapura dan Eropa. Ditemukannya nematoda pelubang akar Radopholus similis pada medium tanam kokopit menyebabkan dikeluarkannya Notification of Non-Compliance (NNC) oleh negara tujuan. Penelitian ini bertujuan mengekplorasi penggunaan teknik Direct Electric System (DES) untuk mengeliminasi nematoda pelubang akar R. similis yang ditemukan pada medium tanam kokopit. Percobaan laboratorium dilakukan untuk mengevaluasi efek penggunakan DES pada berbagai tegangan, jarak elektroda dan lama pemaparan pada medium tanah dan kokpit terhadap mortalitas R. similis. Percobaan rumah kaca dilakukan untuk mengetahui pengaruh DES terhadap mortalitas R. similis dan pertumbuhan tanaman D. reflexa. Hasil penelitian menunjukkan bahwa pada medium tanah dan kokopit kematian nematoda berturut-turut sebesar 83.46% dan 86.17% tercapai dengan tegangan DES 1500 V, serta jarak elektroda 1 dan 2 cm selama 15 menit. Perlakuan DES pada tegangan 1500 V selama 15 menit pada medium kokopit tidak menurunkan pertumbuhan D. reflexa di rumah kaca.
Comparative Evaluation of Tooth Enamel Surface Microhardness Exposed to Novel Modified Casein Phosphopeptide Amorphous Calcium Phosphate, APF Gel and GC Tooth Mousse
Authors:   Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India, Rahmath Meeral P , Pandiyan Indumathy ,   Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India, Arumugham Meignana ,   Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
Published: September 2024

Objective: The acidic pH of remineralizing agents is beneficial in etching the enamel to facilitate increased remineralization. This study aims to modify the pH of Casein Phosphopeptide Amorphous Calcium phosphate to acidic and evaluate the enamel surface microhardness exposed to acidified CPP ACPF, acidulated phosphate fluoride (APF gel), and conventional CPP ACPF. Methods: The pH of conventional CPP ACPF (GC Tooth Mousse) is acidified. 24 tooth samples were assigned into three groups receiving as follows: Group 1 (n = 8) acidified CPP ACPF, Group 2 (n = 8) APF gel, and Group 3 (n = 8) CPP ACPF for four minutes. Baseline and post-exposure microhardness values were evaluated using Vicker’s microhardness number. Descriptive and inferential statistics were done. Results: The mean post-surface microhardness was highest in the acidified CPP ACPF group (323 ± 26.0) while lowest in the CPP ACPF group (307 ± 31). The APF gel group had a 312.4±18.6. A one-way ANOVA test between the groups showed statistical significance (p value 0.054), post hoc Tuckey test showed significance between the acidified CPP ACPF and CPP ACPF groups (p value 0.05). Conclusion: Acidified CPP ACPF increased the surface microhardness less than APF gel in a single exposure for four minutes.
Clinical Features of Anterior Teeth Affected by Molar Incisor Hypomineralization and Treatment Experiences Using Transilluminated Light: A Cross-Sectional Study
Authors:   Hanoi National Hospital of Odonto-Stomatology, Hanoi, Vietnam. Address: 40B Trang Thi Street, Hang Bong Ward, Hoan Kiem District, Hanoi 100000, Vietnam, Thanh Ha Pham , Phuong Huyen Nguyen ,   Hanoi National Hospital of Odonto-Stomatology, Hanoi, Vietnam. Address: 40B Trang Thi Street, Hang Bong Ward, Hoan Kiem District, Hanoi 100000, Vietnam, Kim Thanh Pham ,   Phuong Thanh Dental Center, Dong Thap, Vietnam. Address: 483 Hung Vuong Street, Ward 1, Sa Dec City, Dong Thap 81000, Vietnam, Minh Hang Luong ,   School of Dentistry, Hanoi Medical University, Hanoi, Vietnam. Address: 1 Ton That Tung Street, Kim Lien Ward, Dong Da District, Hanoi 100000, Vietnam, Tuan Anh Tran ,   Becamex International Hospital, Binh Duong, Vietnam. Address: Go Cat Area, Lai Thieu Ward, Thuan An City, Binh Duong 82000, Vietnam, Truong Nhu Ngoc Vo ,   School of Dentistry, Hanoi Medical University, Hanoi, Vietnam. Address: 1 Ton That Tung Street, Kim Lien Ward, Dong Da District, Hanoi 100000, Vietnam, Kha Anh Le ,   Division of Research and Treatment for Oral Maxillofacial Congenital Anomalies, Aichi Gakuin University, Japan. Address: 2-11 Suemori-dori, Chikusa-ku, Nagoya 464-8651, Japan, Anh Tuan Tran ,   School of Dentistry, Hanoi Medical University, Hanoi, Vietnam. Address: 1 Ton That Tung Street, Kim Lien Ward, Dong Da District, Hanoi 100000, Vietnam, Thanh Dong Ta ,   School of Dentistry, Hanoi Medical University, Hanoi, Vietnam. Address: 1 Ton That Tung Street, Kim Lien Ward, Dong Da District, Hanoi 100000, Vietnam
Published: September 2024

Classification and resin infiltration treatment of MIH-related permanent anterior teeth are increasingly receiving attention nowadays. Objective: The study aims to evaluate the characteristics of these teeth; and to assess factors regarding treatment. Methods: A cross-sectional study was conducted using transilluminated and reflected light photographs, and the lesion was classified according to its color, size, type, heterogeneity and surface integrity. The data were analyzed using a chi-square test and multivariate logistic regression analysis to evaluate enamel craze lines (ECL), post-eruptive breakdown (PEB), and treatment procedures. Results: 73 teeth from 46 patients were included, in which 53 teeth had been treated. Size I showed the highest rate of PEB (66.67%). Females (OR = 20.39 (95%CI: 1.62 – 256.18)) and colored lesions (OR = 13.01 (95%CI: 1.82 – 93.13)) were associated with ECL/PEB. Microabrasion and etching cycles were inversely proportional and PEB required 4.33 etching cycles on average. A significant relationship was observed between surface integrity and composite fillings, between yellow/brown spot transformation and lesion color, sex and homogeneity. Conclusion: Lesion color, size, and sex are significant factors influencing ECL and PEB, while sex, surface integrity, lesion color, and homogeneity affect the treatment. Dental practitioners should consider these factors to provide appropriate treatment planning and consultation.
Macrophages modulate skeletal muscle wasting and recovery in acute lung injury in mice
Authors: Krall Jennifer T. W. , Belfield Lanazha , Strysick Claire , Liu Chun , Purcell Lina , Stapleton Renee , Toth Michael , Poynter Matthew , Zhu Xuewei , Gibbs Kevin , Files D. Clark
Published: September 2024

Skeletal muscle dysfunction in critical illnesses leaves survivors weak and functionally impaired. Macrophages infiltrate muscles; however, their functional role is unclear. We aim to examine muscle leukocyte composition and the effect of macrophages on muscle mass and function in the murine acute lung injury (ALI)‐associated skeletal muscle wasting model. We performed flow cytometry of hindlimb muscle to identify myeloid cells pre‐injury and time points up to 29 days after intratracheal lipopolysaccharide ALI. We evaluated muscle force and morphometrics after systemic and intramuscular clodronate‐induced macrophage depletions between peak lung injury and recovery (day 5–6) versus vehicle control. Our results show muscle leukocytes changed over ALI course with day 3 neutrophil infiltration (130.5 ± 95.6cells/mg control to 236.3 ± 70.6cells/mg day 3) and increased day 10 monocyte abundance (5.0 ± 3.4%CD45+CD11b+ day 3 to 14.0 ± 2.6%CD45+CD11b+ day 10, p = 0.005). Although macrophage count did not significantly change, pro‐inflammatory (27.0 ± 7.2% day 3 to 7.2 ± 3.8% day 10, p = 0.02) and anti‐inflammatory (30.5 ± 11.1% day 3 to 52.7 ± 9.7% day 10, p = 0.09) surface marker expression changed over the course of ALI. Macrophage depletion following peak lung injury increased muscle mass and force generation. These data suggest muscle macrophages beyond peak lung injury limit or delay muscle recovery. Targeting macrophages could augment muscle recovery following lung injury.
Cigarette smoke exposure impairs early‐stage recovery from lengthening contraction‐induced muscle injury in male mice
Authors: Stevens Nicole E. , Loreti Mafalda , Ramirez‐Sanchez Israel , Dos Reis Felipe C. G. , Sacco Alessandra , Breen Ellen C. , Nogueira Leonardo
Published: September 2024

The use of tobacco cigarettes produces locomotor muscle weakness and fatigue intolerance. Also, smokers and chronic obstructive pulmonary disease patients have a greater incidence of muscle injury and a deficient myogenic response. However, the effects of smoke exposure on the recovery from eccentric exercise‐induced muscle injuries are unknown. Mice were exposed daily to cigarette smoke (CS) or room air (Air) for 4 months; the anterior crural muscles from one limb were injured by a lengthening contractions protocol (LCP) and recovered for 7 days. Lung compliance was greater, and body weights were lower, in CS‐exposed than in the Air group. In LCP‐subjected limbs, CS exposure lowered tibialis anterior myofiber cross‐sectional area, decreased the size of centrally nucleated myofibers, and decreased extensor digitorum longus (EDL) mass, but did not affect EDL force from both limbs. CS exposure upregulated the mRNA levels of several myogenic (Pax7, Myf5, nNOS) genes in the EDL. The combination of CS exposure and LCP decreased Myf5 and nNOS mRNA levels and exacerbated pro‐inflammatory mRNA levels. These data suggest that smoke exposure leads to an excessive pro‐inflammatory response in regenerating muscle that is associated with a lower muscle mass recovery from a type of injury that often occurs during strenuous exercise.
Current developments and advancements of 3-dimensional printing in personalized medication and drug screening
Authors: Tonk Megha , Gupta Vishal , Dhwaj Amar , Sachdeva Monika
Published: September 2024

Introduction

3-Dimensional printing (3DP) is an additive manufacturing (AM) technique that is expanding quickly because of its low cost and excellent efficiency. The 3D printing industry grew by 19.5 % in 2021 in spite of the COVID-19 epidemic, and by 2026, the worldwide market is expected to be valued up to 37.2 billion US dollars.

Content

Science Direct, Scopus, MEDLINE, EMBASE, PubMed, DOAJ, and other academic databases provide evidence of the increased interest in 3DP technology and innovative drug delivery approaches in recent times.

In this review four main 3DP technologies that are appropriate for pharmaceutical applications: extrusion-based, powder-based, liquid-based, and sheet lamination-based systems are discussed. This study is focused on certain 3DP technologies that may be used to create dosage forms, pharmaceutical goods, and other items with broad regulatory acceptance and technological viability for use in commercial manufacturing. It also discusses pharmaceutical applications of 3DP in drug delivery and drug screening.

Outlook

The pharmaceutical sector has seen the prospect of 3D printing in risk assessment, medical personalisation, and the manufacture of complicated dose formulas at a reasonable cost. AM has great promise to revolutionise the manufacturing and use of medicines, especially in the field of personalized medicine. The need to understand more about the potential applications of 3DP in medical and pharmacological contexts has grown over time.
Green synthesis and effective genistein production by fungal β-glucosidase immobilized on Al2O3 nanocrystals synthesized in Cajanus cajan L. (Millsp.) leaf extracts
Authors: Ali Sikander , Ejaz Afra , Rukhma  , Usman Ahmad M. , Ullah Najeeb , Sarwar Abid , Aziz Tariq , Albekairi Thamer H. , Alshammari Abdulrahman
Published: September 2024

The research deals with the isoflavone genistein production, followed by the β-glucosidase production from Aspergillus oryzae. The Cajanus cajan leaf extract was prepared and the optimized extraction parameters were leaf powder weight (1 g), agitation time (75 min), and temperature (60°C). The optimal conditions for β-glucosidase production by submerged fermentation were 0.4% (w/v) (NH4)2SO4 as nitrogen source, 0.05% (w/v) MgSO4 as magnesium source, 2 ml (v/v) size of inoculum, and 60 min incubation time. The Al2O3 nanocrystals (NCs) were synthesized by optimal volume of leaf extract (25 ml) and procurement period (50 min) along with Al2NO3 and NaOH. The β-glucosidase immobilization on Al2O3 NCs improved the specific activity from 2.38 ± 0.002 to 5.64 ± 0.07 U·mg−1. The maximum genistein production was achieved with the rate of biotransformation (48 h) and enzyme concentration (1% (v/v)) along with the substrate level. In fourier transform infrared spectroscopy analysis, the difference between both β-glucosidases free and Al2O3 immobilized was obtained with peaks at 1,120 and 2,150 cm−1. The X-ray diffraction analysis for the NCs was obtained from 10° to 80° with several intensities. and zeta potential size distribution was recorded at 16.2% of intensity with 206.4 d nm. After immobilization, the stability of the β-glucosidase was increased, thereby increasing its potential in the pharmaceutical, biofuel, food, and beverage industries.
Group boundaries in humor in the online public sphere
Authors: Fiadotava Anastasiya , Chłopicki Władysław
Published: September 2024

One of the fundamental functions of humor is establishing the boundaries between groups. While it is very easy to trace this function in private settings, it often becomes more challenging in the online public sphere, where different groups of humor audiences overlap; there, using audience-restricting references can be counterproductive by establishing boundaries and preventing the efficient spread of jokes. Using the database on humor and conflicts in the public sphere, we look at how humor producers use both in-group specific and widely known humorous references (that we call universal) to create jokes and memes. Based on a corpus of Belarusian and Polish public humor, we outline the most common specific categories of references, analyze how the prevalence of certain categories and types of references depends on the nature of the controversies, and explore the connections between the types of references (verbal or visual) and their nature (in-group and universal).
Migration of two rigid spheres translating within an infinite couple stress fluid under the impact of magnetic field
Authors: El-Sapa Shreen , Alotaibi Munirah Aali
Published: September 2024

In this study, we examine the movement of two hard spheres aligned in a straight line within an incompressible couple stress fluid under the impact of the magnetic field. Both objects have distinct shapes and move along an axis connecting their centers with varying velocities. As a first step, an incompressible analytical analysis is performed on a fluid with couple stress properties around an axially symmetric particle. Using the superposition principle, a general solution is developed for couple stress fluid flows over two moving objects. In order to achieve the boundary conditions, the boundary collocation strategy is applied to the surfaces of the two spheres. A set of tables and graphs illustrates numerical estimates of the dimensionless drag forces acting on two spherical objects. In addition, a drop in Hartmann number or an increase in couple stress viscosity will increase the dimensionless drag force on each spherical particle.
The evolutionary dynamics of grammatical gender in Torricelli languages
Authors: Jódar-Sánchez Jose A. , Allassonnière-Tang Marc
Published: September 2024

Grammatical gender in New Guinea is an often neglected area in typological research, even though it is extremely diverse. For example, in New Guinea, some languages have grammatical gender systems with two sex-based categories, more than four gender-indexing targets, and no gender marking on nouns, while some languages have grammatical gender systems with much more categories, which are only marginally sex-based. This paper infers the processes of development and change of grammatical gender in Torricelli languages from two perspectives. First, it synthesizes the available data in the existing literature and hypothesizes the evolutionary pathway of gender systems in Torricelli languages. Nineteen Torricelli languages are selected as a representative coverage of the 55 Torricelli languages listed in Glottolog within the limits of the available documentation. These languages are then coded based on 6 presence-absence features relating to gender marking on verbs, adjectives, nouns, numerals, pronouns, and demonstratives. Second, it conducts an analysis with phylogenetic comparative methods to provide a quantitative assessment of the evolutionary possibilities for gender systems in Torricelli languages. The preliminary results show that gender is likely marked at the root of Torricelli languages, with pronouns and verbs being at the core of the system. This is in agreement with trends reflecting the evolution of gender systems in languages across the world.
Improvement and optimization of Cu2ZnSn(S1-xSex)4 structure for optoelectronic applications
Authors:   LATSI Laboratory, Faculty of Technology, University of Saad Dahlab Blida1, Algeria, Skender A. , Aissat A. ,   University of Ahmed Draia, Adrar, Algeria, Vilcot J. P. ,   Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR CNRS 8520, University of Sciences and Technologies of Lille 1, Avenue Poincare, 60069, 59652 Villeneuve of Ascq, France
Published: September 2024

The use of semiconductors based on abundant and less expensive materials in photovoltaic industry has grown since electricity consumption has increased, alloys such as Cu2ZnSn(S1-xSex)4 have recently attracted attention, due to its structural, optical and electronic properties which make it a very promising candidate as an absorber layer in photovoltaic applications. The lattice mismatch of Cu2ZnSn(S1-xSex)4 with Cu2NiGeS4 as substrate for solar cell architecture reveals that low Se content (0.1≤x≤0.4) is favorable, and thus, by reducing Se content from 40 to 10% induces a decrease in optical parameters such as refractive index from 5.475 to 3.834 for near-infrared wavelengths, and both extinction and absorption coefficients are from 0.478 to 0.211 and from 7.956×104 to 6.912×104 cm-1 , respectively, for almost along the visible spectrum. Additionally, the bandgap energy of Cu2ZnSn(S1-xSex)4 in kesterite structure increases from 1.267 to 1.442 eV at room temperature, while the compressive strain of the epitaxial layer reduces from 3.93 to 2.39% and from 4.62 to 3.17% on the growth plane and following the direction of growth, respectively.
Mathematical modeling of various CdTe/CISSe based hetero-structure photovoltaic cells incorporating Si and CdS: using Scaps 1D simulator
Authors:   Department of Electrical and Electronic Engineering, Southeast University, Bangladesh, Jahan N. A. , Parash S. I. ,   Department of Electrical and Electronic Engineering, Southeast University, Bangladesh, Hossain Asif ,   Department of Electrical and Electronic Engineering, Southeast University, Bangladesh, Chowdhury T. ,   Department of Electrical and Electronic Engineering, Southeast University, Bangladesh
Published: September 2024

In this study, the primary focus was on enhancing the performance of Photovoltaic devices by modifying the ETL and HTL transport layers. We conducted a comprehensive analysis of efficiency and fill factor variations resulting from adjustments in key device parameters, notably the active layer` thickness. The HTL layer employed materials such as CdTe (Cadmium telluride) and CISSe (Copper indium sulfur selenide), while the ETL layer utilized CdS (Cadmium sulfide), ZnO (Zinc oxide), SnOx (Stannous oxalte), SnO2 (Tin oxide), and TiO2 (Titanium dioxide). Additionally, Silicon (Si) was incorporated into our structure. Our highest efficiency recorded was 27.38%, marking a significant achievement for our proposed cell design. In summary, our simulation results underscore the promising performance of the CdTe/CISSe/Si/CdS/ZnO structure, yielding an efficiency of 27.38%, an open-circuit voltage (Voc) of 0.8136V, a short-circuit current density (Jsc) of 41.17428 mA/cm2 , and a fill factor (FF) of 79.36%. The discussions presented herein suggest that our proposed Photovoltaic (PV) Solar Cell holds great potential for adequate performance and improved power conversion efficiency, making it a compelling choice for solar energy applications.
Effect of carrier gas on copper antimony sulfide thin films by spray pyrolytic approach
Authors:   Solar Energy Laboratory, Mohan Babu University (Erstwhile Sree Vidyanikethan Engineering College), Tirupati-517102, India, Kishore Kumar Y. B. , Guru Prasad S. ,   Department of Physics, N.T.R. Government Degree College, Vayalpad-517299, India, Swapna Smitha A. S. ,   Department of Physics, Government Degree College, Puttur-517583, India, Chalapathi U. ,   Department of Electronic Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk, 38541, South Korea, Suresh Babu G. ,   Department of Physics, Government Degree College, Puttur-517583, India, Jayasree Y. ,   Department of Physics, S.P.W. Degree and PG College, Tirupati-517502, India, Uday Bhaskar P. ,   National Institute of Solar Energy, Gwal Pahari, Haryana and Mundra Solar Technology LTD (Adani Solar), Mundra, Gujarat-370435, India, Park Si-Hyun ,   Department of Electronic Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk, 38541, South Korea
Published: September 2024

This study explores the ternary compound semiconductor as a potential absorber layer for third-generation solar cells. CuSbS2, a promising candidate for thin film absorber layers, is fabricated using a simple spray pyrolysis method. The research specifically investigates the influence of two different carrier gases during the fabrication process. X-ray diffraction as well as Raman studies confirm that the films exhibit a chalcostibite structure. Notably, films fabricated with nitrogen as the carrier gas demonstrate enhanced crystallinity, accompanied by reduced microstrain and dislocation density. Furthermore, these films exhibit a significantly improved absorption coefficient, reaching 105 cm-1 . Optical studies indicate that the materials possess a direct band gap of 1.50 eV and exhibit p-type conductivity. CuSbS2 thin film heterojunction solar cell exhibits a maximum efficiency of 0.49%.
Synthesis, structural, and optical characterizations of zinc oxide: silver oxide nanoparticles conjunction with polymer polyvinylpyrrolidone
Authors:   Physics department, college of science, Mustansiriyah University, Baghdad-Iraq, Hamood S. S. , Khalaf M. S. ,   Ministry of Science and Technology, Directorate of treatment of Military, b Biological, and Chemical, Disposal, Baghdad-Iraq, Mohammed F. S. ,   Physics department, college of science, Mustansiriyah University, Baghdad-Iraq
Published: September 2024

Pulsed laser ablation (PLA) technology has been utilized for creating nano-sized particles from silver oxide, zinc oxide, and mixed oxide (Ag2O, ZnO, ZnO: Ag2O) combined with polyvinylpyrrolidone (PVP) for environmental applications, especially the filtration regarding oil-polluted water in rivers. A range of analytical methods have been employed to describe the prepared as well as polymer-supported nanomaterials' characteristics. Energy-dispersive X-ray spectroscopy, scanning \ transmission electron microscopy (SEM \ TEM) analysis, X-ray diffraction \ fluorescence (XRD \ XRF), Fourier-transform infrared spectroscopy, and photoluminescence measurements (PL) were among them. The nanocomposite ZnO: Ag2O showed numerous nanostructures with diverse orientations, according to XRD analysis. SEM imaging of the Ag2O nanoparticles indicated polydispersed spherical particles with widespread aggregation. Furthermore, the study incorporated the use of polymer-supported nanomaterials, with PVP selected for its excellent chemical and thermal resistance. Various membrane structures with differing porosities were prepared and effectively employed for the filtration of oil-polluted water, as validated through TEM, XRF, and other measurements. In this context, the polymer functioned akin to a sponge for water pollution remediation.
A novel heterozygous likely pathogenic SLC5A2 variant in a diabetic patient with glucosuria and aminoaciduria
Authors: Inthasot Saohoine , Vanderhulst Julien , Janssens Peter , Van Daele Sien , Van Hoof Evelien , Kint Cyrielle , Iconaru Laura , de Filette Jeroen
Published: September 2024

Familial renal glucosuria (FRG) is a rare renal tubular disorder characterized by increased urinary glucose excretion despite normoglycemia. It is most commonly caused by pathogenic variants in the solute carrier family V member 2 (SLC5A2) gene. This gene encodes the sodium–glucose cotransporter 2, crucial for glucose reabsorption. We report the case of a 44-year-old male referred to the endocrinology outpatient clinic for unexplained glucosuria despite well-controlled diabetes mellitus with metformin and gliclazide therapy. His main complaints were nocturia and an unintentional 5 kg weight loss in 1 year. A 24-h urinary collection revealed overt glucosuria (23.3 g/1.73 m2/24 h), generalized aminoaciduria, and increased uric acid excretion (fractional excretion: 6.4%). Whole-exome sequencing revealed a novel heterozygous c.469-1G>A likely pathogenic variant in the SLC5A2 gene. Specific analysis of the maturity-onset diabetes of the young type (MODY) gene panel showed no pathogenic variants in the hepatocyte nuclear factor-1A (HNF-1A; MODY3) nor in other MODY-associated genes. We assume that the association of glucosuria, aminoaciduria, and increased uric acid excretion can be explained by the combination of diabetes and the likely pathogenic SLC5A2 variant in this patient. In conclusion, we describe a well-controlled diabetic patient with FRG, associated with a novel heterozygous c.469-1G>A likely pathogenic variant in the SLC5A2 gene.

Learning points

The diagnosis of a renal tubular disorder should be considered in patients with unexplained glucosuria and diabetes mellitus, especially if the latter is well controlled.

FRG usually presents with glucosuria but may be associated with generalized aminoaciduria and hyperuricosuria.

Genetic analysis should be considered in patients with young-onset diabetes and glucosuria, particularly with a positive family history.
CORRUGATED SEMICONDUCTOR NANOMEMBRANES BASED ON STRAINED HETEROSTRUCTURES: FABRICATION AND MAGNETOTRANSPORT
Authors: СЕЛЕЗНЕВ В.А. , ГОЛОД С.В. , ВОРОБЬЁВ А.Б. , КОЗИК Е.В. , ПРИНЦ А.В. , ПРИНЦ В.Я.
Published: September 2024

Работа посвящена фундаментальным исследованиям в области наномеханики гофрированных полупроводниковых наномембран из напряжённых гетероструктур. Приводятся результаты исследования магнитотранспорта двумерного электронного газа в гофрированной наномембране из гетероплёнки GaAs/InGaAs.

The manuscript considers fundamental research in the field of nanomechanics of corrugated semiconductor nanomembranes composed of strained heterostructures. The results of a study of the magnetotransport of a two-dimensional electron gas in a corrugated nanomembrane made of a GaAs/InGaAs heterofilm are presented.
LOW-TEMPERATURE CONDUCTANCE OF NANOSYSTEMS UNDER CONDITIONS OF WEAK COUPLING WITH A MICROWAVE GENERATOR
Authors: ЯРОШЕВИЧ А.С. , ТКАЧЕНКО В.А. , КВОН З.Д. , КУЗЬМИН Н.С. , ТКАЧЕНКО О.А. , БАКШЕЕВ Д.Г. , МАРЧИШИН И.В. , БАКАРОВ А.К. , РОДЯКИНА Е.Е. , АНТОНОВ В.А. , ПОПОВ В.П. , ЛАТЫШЕВ А.В.
Published: September 2024

Сильный отклик наносистем на воздействие слабой СВЧ-мощности через зазор между образцом и концом коаксиального кабеля от генератора микроволн обнаружен измерениями при 4,2 К кондактанса короткоканального кремниевого транзистора p -типа, а также образцов с коротким квантовым точечным контактом в двумерном электронном газе гетероструктур GaAs/AlGaAs. Отклик кондактанса был гигантским в туннельном режиме устройств, а вне этого режима знак СВЧ-фотокондактанса зависел от мезоскопического состояния образца и изучаемого интервала по затворному напряжению. Механизм обнаруженных эффектов выяснен моделированием мезоскопического транспорта в рамках одночастичной квантовой механики и формулы Ландауэра, а также анализом принципиальных схем электрического управления полупроводниковым устройством. Найденной основной причиной отклика наносистем на СВЧ-воздействие являются вынужденные синфазные осцилляции заряда в контактах к полупроводнику из-за ёмкостных связей в ближнем металлическом окружении образца.

A strong response of nanosystems to the action of weak microwave power through the gap between the sample and the end of the coaxial cable from the microwave generator is detected by measurements at 4.2 K of the conductance of a short-channel p-type silicon transistor, as well as samples with a short quantum point contact in a two-dimensional electron gas of GaAs/AlGaAs heterostructures. The conductance response is gigantic in the tunnel regime of the devices; outside this regime, the sign of the microwave photoconductance depends on the mesoscopic state of the sample and the gate voltage interval under study. The mechanism of the discovered effects is elucidated by modeling mesoscopic transport within the framework of single-particle quantum mechanics and the Landauer formula, as well as by analyzing the basic circuits of electrical control of the semiconductor device. The main reason for the response of nanosystems to microwave exposure is found to be forced in-phase charge oscillations in contacts to the semiconductor due to capacitive connections in the near metallic environment of the sample.
EFFECT OF HUMIDITY AND ELECTRIC FIELD ON THE PROCESS OF LOCAL ANODIC OXIDATION OF THE SI(111) SURFACE BY AN AFM PROBE
Authors: ЩЕГЛОВ Д.В. , ФЕДИНА Л.И. , ЛАТЫШЕВ А.В.
Published: September 2024

Исследовано локальное анодное окисление (ЛАО) поверхности Si(111) в контактном режиме работы атомно-силового микроскопа (АСМ) в зависимости от относительной влажности окружающей среды Θ (35-75) % при двух потенциалах U (-8 и -10 В), приложенных к зонду АСМ. Показано, что ЛАО для U = -8 В реализуется при Θ ≥ 40 % в отсутствие роста оксидных линий в ширину, а при U = -10 В их высота и ширина линейно растут во всём интервале значений Θ. Предложена обобщённая модель зависимости процесса ЛАО от U и Θ на основе детального анализа ЛАО и изгиба балки кантилевера при подводе и отводе зонда от поверхности при вариации Θ без напряжения на зонде с учётом данных научной литературы для полуконтактного режима работы АСМ.

Local anodic oxidation (LAO) of the Si(111) surface in the contact mode of an atomic force microscope (AFM) is studied depending on the relative humidity of the ambience - (35-75)% at two potentials U (-8 and -10 V) applied to the AFM probe. It is shown that LAO for U = -8V is realized at Θ ≥ 40% in the absence of growth of oxide lines in width; at U = -10V, their height and width increase linearly over the entire range of Θ values. Based on a detailed analysis of LAO and the deviation of the cantilever during the approach and retraction of the probe from the surface with variation of Θwithout voltage on the probe, taking into account literature data for the semi-contact mode of AFM operation, a generalized model of the dependence of the LAO process on U and Θis proposed.
SURFACE-ENHANCED RAMAN SCATTERING FROM GAP NANOWIRES WITH A GALLIUM DROPLET
Authors: ТАРАНЕНКО А.В. , БАСАЛАЕВА Л.С. , ФЁДОРОВ В.В. , ТУМАШЕВ В.С. , МИЛЁХИН А.Г.
Published: September 2024

Представлены результаты исследования структурных и оптических свойств массивов и одиночных нанопроволок (НП) GaP ориентации (111) с помощью спектроскопии комбинационного рассеяния света (КРС) и атомно-силовой микроскопии (АСМ). Массивы НП GaP были выращены на подложке Si(111) методом самокаталитического роста по механизму пар - жидкость - кристалл. Одиночные НП GaP были механически перенесены на золотую поверхность. В спектрах КРС НП GaP наблюдались моды поперечных (TO), продольных (LO) и поверхностных (SO) оптических фононов. Обнаружено поверхностно-усиленное КРС фононными модами GaP вблизи галлиевой капли, обусловленное возникающим локализованным поверхностным плазмонным резонансом в капле. Получены карты КРС НП GaP для различной геометрии рассеяния. Коэффициент усиления сигнала КРС для НП GaP диаметром 104 и 60 нм достигает значений ~11 и 6 соответственно.

This paper presents the results of a study of the structural and optical properties of arrays of (111)-oriented GaP nanowires (NWs) and single NWs using Raman spectroscopy and atomic force microscopy (AFM). GaP NW arrays are grown on a (111)-Si substrate by self-catalytic growth via the vapor-liquid-crystal mechanism. Single GaP NWs are mechanically transferred onto a gold surface. Transverse (TO), longitudinal (LO), and surface (SO) optical phonon modes are observed in the Raman spectra of GaP NWs. Surface-enhanced Raman scattering by optical phonon modes in GaP NWs near a gallium droplet is detected, due to the localized surface plasmon resonance in the droplet. Raman maps for GaP NWs recorded on various scattering geometries are obtained. The Raman enhancement factor for GaP NWs with a diameter of 104 and 60 nm reaches values of ~11 and 6, respectively.
IDENTIFICATION OF ACOUSTIC EMISSION SIGNATURES OF THE DIRECT LASER MELTING PROCESS
Authors: СТЕПАНОВА К.А. , КУЗИВАНОВ Д.О. , ФЕДОРОВ А.В. , КИНЖАГУЛОВ И.Ю.
Published: September 2024

Представлены результаты формирования акустико-эмиссионных образов процессов, происходящих при прямом лазерном выращивании. В рамках экспериментального исследования на различных режимах проведено выращивание образцов из порошкового сплава ЭП 648 с одновременной регистрацией сигналов акустической эмиссии. По результатам анализа параметров зарегистрированных сигналов сформированы их характерные паттерны распределения при лазерном выращивании бездефектных и дефектного образцов.

The paper presents results of identification of acoustic emission signatures of processes occurring during direct laser melting. As part of the experimental study, samples from the powder alloy EP 648 are grown in various modes with simultaneous recording of acoustic emission signals. Based on the results of the analysis of the registered signals parameters, their characteristic distribution patterns are formed during laser melting of defect-free and defective samples.
CRUSHED ROCK STRENGTH TESTING AT IRON RIDGE DEPOSIT
Authors: БАБЕЛЛО В.А. , ЛИЗУНКИН В.М. , ЛИЗУНКИН М.В. , СОБОЛЕВ С.А.
Published: September 2024

Для расчета устойчивости ограждающей дамбы хвостохранилища проведены экспериментальные исследования раздробленных скальных пород на крупногабаритном стенде методом среза целиков. Определены их прочностные свойства при различных значениях гранулометрического состава и плотности, а также диаметра срезных колец и нормального давления. Установлено, что угол внутреннего трения раздробленных скальных пород в уплотненном состоянии изменяется в диапазоне 35 -40°, сцепление от 0.0256 до 0.0293 МПа, в неуплотненном состоянии в диапазоне 25 - 30° и от 0.0163 до 0.0184 МПа соответственно.

Crushed rock shear tests are carried out to determine stability of a tailings pond dam. The tests allow finding the rock strength at different grain composition and density of rocks, as well as at different shear ring diameters and normal pressures. It is found that the internal friction angle and cohesion range as 35-40° and 0.0256-0.0293 MPa, respectively, in compacted rocks, and as 25-30° and 0.0163-0.0184 MPa, respectively, in uncompacted rocks.
ACTION CHART AND MAIN CONTROLLABLE PARAMETERS OF DUTY CYCLE OF PNEUMATIC PERCUSSION MACHINE
Authors: ПЛОХИХ В.В. , ДАНИЛОВ Б.Б. , ЧЕЩИН Д.О.
Published: September 2024

Проведен анализ конструктивных схем пневматических ударных машин и обосновано применение пневмоударной машины, созданной на основе комбинированного воздухораспределения с использованием упругого клапана, для реализации адаптивных технологических процессов. Представлены результаты теоретических и экспериментальных исследований динамики рабочего цикла пневмоударного устройства с возможностью регулировки его энергетических параметров в процессе работы.

The structural layouts of pneumatic percussion machines are reviewed. The use of a pneumatic percussion machines with mixed-type air distribution via elastic valve is substantiated for implementation of adaptive technologies. The authors present the theoretical and experimental studies into dynamics of duty cycle of a pneumatic percussion tool with on-line power adjustability.
SELECTING ORGANIC COLLECTORS FOR LUMINOPHORE-BEARING MODIFYING AGENTS TO EXTRACT WEAKLY FLUORESCENT DIAMONDS
Authors: МОРОЗОВ В.В. , ЧАНТУРИЯ В.А. , ДВОЙЧЕНКОВА Г.П. , ЧАНТУРИЯ Е.Л. , ПОДКАМЕННЫЙ Ю.А.
Published: September 2024

Получены зависимости спектрального распределения мощности люминесцентного излучения и спектрально-кинетические характеристики сигнала рентгенолюминесценции органических коллекторов, обосновывающие возможность их применения в составе реагентов-модификаторов. На основе комплексной оценки эффективности органических жидкостей по их адгезионной способности к алмазам и экстракционной способности к неорганическим люминофорам выбраны следующие органические коллекторы: дизельная техническая фракция, тяжелый газойль каталитического крекинга, их смеси. Установлена возможность замещения спектральных функций органических люминофоров содержащимися в органических коллекторах полиароматическими углеводородами, которые формируют интенсивный сигнал, близкий к сигналу органических люминофоров. Показана высокая эффективность реагентов-модификаторов, включающих в состав композиций органические коллекторы и гидрофобизированные люминофоры Э-515-115-Г5 и ФЛ-530-Г3. В качестве органического коллектора применялась смесь тяжелого газойля каталитического крекинга и дизельной технической фракции в соотношении 6:1 - 9:1. Извлечение слабо- и аномально люминесцирующих алмазов составило 80 -90 %, кимберлита не более 1 %. Полученные результаты позволяют рекомендовать разработанные реагенты-модификаторы для применения в промышленных схемах рентгенолюминесцентной сепарации алмазосодержащего материала.

The authors have correlated the fluorescence spectrum with the spectrum and kinetics of X-ray luminescence of organic collectors. The correlations prove applicability of organic collectors with modifying agents. From the integrated evaluation of organic liquids by the criteria of their adhesion capacity relative to diamonds and extraction capacity relative to inorganic luminophores, the selected organic collectors are: diesel, heavy gasoil of catalytic cracking, and their mixture. The spectral functions of organic luminophores contained in organic collectors are replaceable with polyaromatic hydrocarbons which generate intense signals similar to the signals of organic luminophores. Efficiency of modifying agents containing organic collectors and hydrophobic luminophores E-515-115-G5 and FL-530-GZ is high. The test organic collector was heavy gas oil of catalytic cracking and diesel fraction at a ratio of 61-9:1. Recovery of weakly and abnormally fluorescent diamonds was 80-90%, while recovery of kimberlite was not higher than 1%. The results allow recommending the developed modifying agents for the commercial-scale X-ray luminescence separation of diamond-bearing materials.
FUNCTIONALIZED MAGNETIC NANOSORBENTS FOR COPPER EXTRACTION FROM SOLUTIONS
Authors: БРАГИН В.И. , БАКШЕЕВА И.И. , ПЛОТНИКОВА А.А. , БУРДАКОВА Е.А.
Published: September 2024

Обоснована перспективность использования функционализированных магнитных наночастиц для извлечения металлов из технологических растворов и кондиционирования промышленных сточных вод. Приведены результаты экспериментальных исследований по извлечению меди из растворов с использованием магнитного наносорбента на основе магнетита, функционализированного тиоктовой кислотой. Определены характеристики сорбции в зависимости от исходной концентрации растворов в сравнении с нефункционализированным наноразмерным магнетитом. Описан механизм формирования медьсодержащего осадка, включающий хемосорбцию на активных центрах тиоктовой кислоты, сорбцию на чистой поверхности магнетита и дальнейшую перекристаллизацию сорбата в собственные минеральные медьсодержащие фазы. Изучен фазовый состав меди в осадке, показана возможность ее извлечения. Предложена технология кондиционирования медьсодержащих растворов. При стадиальном использовании магнитного наносорбента достигается очистка технологических растворов до норм предельно допустимых концентраций с одновременным получением концентрата для последующей гидрометаллургической переработки.

The article proves the promising nature of using functionalized magnetic nano particles in extraction of metals from process solutions and in treatment of industrial effluents. The experimental copper extraction from solutions using a magnetic nanosorbent made of lipoic acid-functionalized magnetite is described. Sorption efficiency is determined as function of the initial concentration of solutions as compared with non-functionalized nano-size magnetite. The copper-bearing sedimentation mechanism includes chemosorption at active centers of lipoic acid, adsorption at clean magnetite surface and re-crystallization of sorbate in intrinsic copper-bearing phases. The phase composition of copper in the sediments is examined, and the copper extractability is illustrated. The conditioning technology is proposed for copper-bearing solutions. The stage-wise use of the magnetic nanosorbent enables process solution purification up to the maximum allowable concentration at simultaneous production of a concentrate suitable for hydrometallurgical processing.
POST-LEACHING OF SILVER FROM A NON-SULFIDE LEAD-ZINC ORE FLOTATION TAILING LEACH RESIDUE IN A COPPER-AMMONIUM THIOSULFATE SOLUTION: A FUZZY LOGIC PREDICTION
Authors: ХУССАИНИ Ш. , ТИТА А.М. , КУРСУНОГЛУ С. , КУРСУНОГЛУ Н. , ТОП С. , КАЯ М.
Published: September 2024

Рассмотрен метод выщелачивания серебра. Установлена высокая доля растворения серебра 89.7% при концентрации тиосульфата аммония 30 г/л, концентрации сульфата меди 0.5 г/л, температуре выщелачивания 25 °C, продолжительности выщелачивания 4 ч. Построена модель прогнозирования условий растворения серебра на базе нечеткой логики. В качестве критериев выбраны: концентрация тиосульфата аммония, сульфата меди и продолжительность выщелачивания. Данная модель хорошо согласуется с экспериментальными данными. Полученные результаты позволяют применять моделирование на базе нечеткой логики для прогнозирования параметров выщелачивания серебра из хвостов обогащения.

The post-leaching of silver (Ag) from a non-sulfide lead-zinc (Pb-Zn) ore flotation tailing leach residue in a copper-ammonium thiosulfate solution was investigated. Ag (89.7%) was extracted into the leaching solution under the following conditions: 30 g/l ammonium thiosulfate, 0.5 g/l copper sulfate, 25°C leaching temperature and 4 h leaching time. On the basis of the experimental results, a fuzzy logic prediction was made. Ammonium thiosulfate, copper sulfate and leaching period were chosen as predictive criteria in this step. The fuzzy prediction model was found to be very consistent with the experimental data (R2:0.9657). Based on these findings, the application of the fuzzy logic prediction approach to the silver dissolution from the leach residue could be considered.
IMPACT OF INCREASED WATER INFLOW ON MAIN DRAINAGE SYSTEM EFFICIENCY IN MINE
Authors: ОВЧИННИКОВ Н.П. , ЗЫРЯНОВ И.В.
Published: September 2024

Рассмотрено влияние водопритока на работу главной водоотливной установки подземного рудника “Удачный” АК “АЛРОСА”. Установлено, что содержание твердых частиц в шахтных водах повышается при росте водопритока в рудник. Предложен способ по недопущению попадания в рудник в теплое время года дополнительного водопритока, обусловленного планируемым демонтажем одной из насосных станций из-за осыпей бортов нерабочего карьера. Рассчитан ожидаемый срок окупаемости предлагаемого технологического решения.

The article analyzes the impact of water inflow in a mine on the efficiency of the main mine water drainage system as a case-study of Udachny Mine, ALROSA. It is found that the content of solid particles in mine water grows with the increasing water inflow in the mine. A method is proposed to eliminate excessive water inflow in the mine in warm season in case of a pumping station teardown because of the spoil bank slide. The expected payback time of the proposed engineering solution is calculated.