bluuebunny/crossref_metadata_2025 huggingface dataset:
Vinegar Extract Produced Using Ripe Fruits of Wild Genotype of Citrus depressa Hayata in Okinawa
Authors: Hanagasaki Takashi
Published: July 2023

Shikuwasa (Citrus depressa Hayata) is known as Taiwan tangerine. Various local cultivars are grown, among which the most famous is the ‘Kugani’, which is considered a breeding cultivar. The fruits of this cultivar are used for various purposes (juices, jams, vinegar, etc.) and as a fruit for consumption. The local landrace Ishikunibu is considered wild and is not cultivated on a larger scale because it is dwarf and tastes sour even when harvested in February. This article showed the results of experiments that aimed to show that Ishikunibu fruits are suitable as an addition to the cultivation of these fruits for producing vinegar extract. The results indicate that the vinegar extract of Ishikunibu has properties similar to that of ‘Kugani’. Such vinegar extracts using Ishikunibu have more ascorbic acid (115.2 μg·L−1 vs. 38.9 μg·L−1) and titratable acidity than that of ‘Kugani’. The other quality parameters of such produced vinegar extracts did not differ significantly. The sensory evaluation of vinegar extracts showed no differences in aroma, green smell, and general flavor but vinegar extract of Ishikunibu tasted less bitter. Therefore, Ishikunibu, the wild genotype of shikuwasa, is deemed useful in producing vinegar extracts.
The Storage Ability of Broccoli after 1-Methylcyclopropene Treatment
Authors: Grzegorzewska Maria , Badełek Ewa , Ciecierska Anna , Fabiszewski Karol , Rutkowski Krzysztof P.
Published: July 2023

The study evaluated the effect of 1-methylcyclopropene (1-MCP) treatment on broccoli quality and storage ability. Broccoli ‘Parthenon’ was treated the day after harvest with 1.0 or 3.0 cm3·m−3 1-MCP. The treatment was performed at 5 °C for 20 h, and then the plant material was stored at 0–1 °C for 30 or 60 d. After 30 d of refrigerated storage, broccoli was transferred to conditions simulating retail (15 °C) for 6 d. During 30 d of storage, the broccoli crowns maintained excellent quality. The fleshy stalks were slightly inferior due to the darkening of the leaf scar areas. After 60 d, there was a marked reduction in broccoli quality. Still, the positive effect of 1-MCP treatment on broccoli was observed as inhibiting the senescence of the remaining petiole fragments. During shelf life after 30 days of cold storage, broccoli treated with 1-MCP retained better quality of the crowns and fleshy stems, evident after six days of shelf life evaluation. The study did not find that 1-MCP treatment inhibited the respiration rate of broccoli, or ethylene production.
Prediction of Fruit Production in India: An Econometric Approach
Authors: Ray Soumik , Mishra Pradeep , Ayad Hicham , Kumari Prity , Sharma Rajnee , Kumari Binita , Al Khatib Abdullah Mohammad Ghazi , Tamang Anant , Biswas Tufleuddin
Published: July 2023

Forecasting is valuable to countries because it enables them to make informed business decisions and develop data-driven strategies. Fruit production offers promising economic opportunities to reduce rural poverty and unemployment in developing countries and is a crucial component of farm diversification strategies. After vegetables, fruits are the most affordable source of essential vitamins and minerals for human health. India's fruit production strategies should be developed based on accurate predictions and the best forecasting models. This study focused on the forecasting behavior of production of apples, bananas, grapes, mangoes, guavas, and pineapples in India using data from 1961 to 2015 (modelling set) and 2016–2020 (predicting set). Two unit root tests were used, the Ng–Perron (2001) test, and the Dickey–Fuller test with bootstrapping critical values depending on the Park (2003) technique. The results show that all variables are stationary at first differences. Autoregressive integrated moving average (ARIMA) and exponential smoothing (ETS) models were used and compared based on goodness of fit. The results indicated that the ETS model was the best in all the cases, as the predictions using ETS had the smallest errors and deviations between forecasting and actual values. This result was confirmed using three tests: Diebold–Mariano, Giacomini–White, and Clark–West. According to the best models, forecasts for production during 2021–2027 were obtained. In terms of production, an increase is expected for apples, bananas, grapes, mangoes, mangosteens, guavas, and pineapples in India during this period. The current outcomes of the forecasts could enable policymakers to create an enabling environment for farmers, exporters, and other stakeholders, leading to stable markets and enhanced economic growth. Policymakers can use the insights from forecasting to design strategies that ensure a diverse and nutritious fruit supply for the population. This can include initiatives like promoting small-scale farming, improving postharvest storage and processing facilities, and establishing effective distribution networks to reach vulnerable communities.
A Parameter Estimation Algorithm for Damped Real-value Sinusoid in Noise
Authors: Chen Peng , Su Xin , Shen Ting’ao , Mou Ling
Published: July 2023

To improve the parameter estimation performance of damped real-value sinusoid in noise, a novel algorithm with high accuracy and computational efficiency is proposed that combines the characteristics of good anti-interference, small computation of frequency-domain methods, and high parameter estimation accuracy of time-domain methods. First, the Discrete Fourier Transform (DFT) algorithm and the two-point spectrum interpolation algorithm of the frequency-domain methods are used to improve the noise immunity. Then, the linear prediction property and the enhancement filter of the time-domain methods are used to improve the parameter estimation accuracy. In addition, the parameter estimation performance of the proposed algorithm is verified by computational complexity analysis and test experiments, and the practical application effectiveness of the proposed algorithm is demonstrated on the Coriolis Mass Flowmeter (CMF) experimental platform. The experimental results show that the proposed algorithm effectively improves the real-time performance and the parameter estimation accuracy is better than that of the existing excellent algorithms.
Study on Time-frequency Imaging of Ultrasonic Detection with Phase Shifted Fiber Bragg Grating Sensing
Authors: Meng Lijun , Tan Xin , Yu Quanquan
Published: July 2023

The influence of the wavelength difference between the laser source and the phase-shifted fiber Bragg grating (PS-FBG) on the intensity of the power demodulation system based on an adjustable laser source was studied experimentally, and the optimum of the output laser wavelength was determined. Then, the research on time-frequency imaging damage identification based on smooth pseudo-Wigner-Ville distribution was carried out. The Time of Flight of the acoustic wave signal was calculated and time compensation was made according to the Wigner-Ville distribution and the Lamb wave dispersion curve. The ultrasonic waves before and after damage were measured with spatially arranged PS-FBGs. The difference signals were processed in a window, and then the time-frequency energy of the normalized difference signal was imaged to assess the damage detection and location. Although the mode and group velocity of ultrasound measured by each fiber grating were different, the accurate location and identification of artificial damage in an aluminum alloy plate was realized by using only three PS-FBGs and a smooth Wigner time-frequency imaging method.
Conversion of the Bruker Minispec Instrumentation into the Static Magnetic Field Standard
Authors: Andris Peter , Frollo Ivan , Přibil Jiří , Gogola Daniel , Dermek Tomáš
Published: July 2023

The static magnetic field standard is part of many scientific experiments aimed at measuring the magnetic field. Often this device has to be built by oneself, if there is no possibility to buy it off the shelf. One possibility is also to convert a suitable device into a static magnetic field standard. Such a method is also described in this article. When the first experiments showed that the key parts could not be obtained under the existing conditions, it was decided to convert Bruker’s Minispec into a static magnetic field standard. Such a standard will not be completely universal, but it will accommodate many experiments, and the experience may help in the future when a more perfect standard is built. This article describes the design of the apparatus, briefly describing all the equipment, which includes many parts of the original device. The parts specific to the new construction are described in more detail. An alternative solution for frequency deviation calculation using a software quadrature detector, tested only in the form of a computer simulation, is also described.
The Apparatus for Thermomechanical Analysis of Clay-based Ceramics
Authors: Húlan Tomáš , Štubňa Igor , Al-Shantir Omar , Trník Anton
Published: July 2023

A dynamic thermomechanical analysis (D-TMA) apparatus is described for measuring the resonant frequency of the flexural vibration and the internal damping of the sample using the impulse excitation technique (IET). Since the measurement is conducted at temperatures up to 1250 °C, an electromagnetic impulser is used for excitation. The free vibrations are registered by an electret microphone, stored and then converted into a frequency spectrum using the fast Fourier transform, from which the resonant frequency can be found. The furnace is built from refractory porous alumina bricks and alumina fiber pads. The heating elements are four SiC rods connected to a temperature controller. The temperature is measured with a Pt-PtRh10 thermocouple in close proximity to the sample.
The Influence of the Movement Method on the Results of Machine Tool Positioning Accuracy Analysis
Authors: Budimir Alexander , Tabaković Slobodan , Zeljković Milan
Published: July 2023

The improvement of machine tools, and therefore, of industrial production, requires high accuracy of machining while adapting to the different dimensions of the workpieces and to the machines themselves. As a result, the improvement of testing procedures and the analysis of positioning accuracy results represent an important research task in modern manufacturing engineering. The paper presents the results of the research carried out with the aim of determining the influence of the choice of parameters for standardized testing of positioning accuracy on the measurement results with reference to the characteristics of the machines from the point of view of the size of the workspace and the machines themselves. In this way, it is possible to choose the appropriate test parameters of the machine tools depending on their geometrical characteristics and test conditions and within the existing standards.
The analysis of the predictive factors of mortality in patients with acute mesenteric ischemia
Authors: Renáta Moriczi , Ruxandra Daniealopol , István Kiss Botond , Valentin Daniealopol , Loránd-Tibor Reman , Radu Neagoe , Árpád Török
Published: July 2023

Background: The acute mesenteric ischemia is a rare life-threatening surgical condition, followed by high mortality and morbidity rate. Disparate etiologies and nonspecific symptoms make the diagnosis and the surgery delayed, which leads to a higher mortality rate (60-80%).

Methods: This research was designed as a retrospective study, including a total of 86 patients operated for acute mesenteric ischemia between 2014 and 2020 at the 2nd Department of Surgery in Mureș County Emergency Clinical Hospital. We recorded and analyzed the demographic, clinical, pre-operative radiological and laboratory, and surgical findings of the patients. Results: We analyzed the findings of 86 patients (59,3% men, 40,7% women), the mortality rate was 77,9% (77% in women, 78% in men), and the average age was 76,81 years. The youngest patient was 39 years old and the oldest was 96 in the moment of the diagnosis. The mortality rate was higher (93%) in patients, who suffered just an explorative laparotomy surgery (in 50% of the cases, p=0,001, Chi-squared test). The presence of the peritonitis (12 cases) had a negative impact on the survival rate, every patient who had peritonitis described on the computed tomography died after the surgical intervention (p=0,047, Chi-square test). Statistically, there was not a positive relationship between the time spent in the Emergency Room and the mortality rate, but this time was much longer in the group of patients who died after the surgery, 408,22 minutes, compared to the group of the patients who survived, 352,47 minutes (p=0,431, T-test). The survival rate was higher in patients who had abdominal surgery in the personal history (p=0,021, Chi-square test).

Conclusions: The symptoms and the paraclinical findings of patients with acute mesenteric ischemia are not specific, so the fast radiological examinations and the optimal time for the surgical intervention represent the key of the improvement of the survival rate.
Cytomorphological analysis of histologically confirmed cases of medullary thyroid carcinoma
Authors: Tibor Mezei , Mónika Gyenge , Kriszta-Beáta Gurza , Ildikó Orbán , Zsuzsanna Réti , Ionela Pașcanu , Melinda Kolcsár
Published: July 2023

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine malignant tumor of parafollicular C-cell origin of the thyroid gland, whose tumor cells typically produce calcitonin. The serum level of calcitonin produced by tumor cells is a sensitive tumor marker. An elevated serum level of this and the simultaneous presence of a thyroid nodule confirmed by ultrasound raise a reasonable suspicion of MTC. Still, the first-line MTC confirmation method in diagnosing MTC is fine-needle aspiration cytology (FNA). Objective: The aim of our study was the clinicopathological and cytomorphological analysis of histologically confirmed MTC cases obtained with FNA, as well as their comparison with the clinicopathological and cytomorphological characteristics of papillary thyroid carcinoma (PTC). Material and method: In our retrospective study, we analyzed the FNA cytology findings of patients with nodular goiter examined between 2013-2019 and the available clinical data. Results: In the 7-year period, 1,808 fine-needle aspiration examinations were performed, of which we identified 12 MTC and 77 PTC cases. The average age of patients diagnosed with MTC was 53±13 years. There were nine women and three men in examined cases. The average diameter of the nodules was 14±5 mm. All of our cases were of the sporadic type. The average age of patients diagnosed with MTC was greater than that of patients diagnosed with PTC (53 vs. 44 years, p=0.02367). A female predominance is observed in both diseases, although this is more pronounced in PTC. The diameter of the MTC nodules does not differ significantly from the mean size of the PTC nodules (14 vs. 17 mm, p=0.3138). The cytomorphological characteristics of the MTC cases we examined correspond to those described in the international literature, with minor differences. Conclusions: MTC is one of the rarer thyroid cancers, which is often difficult to distinguish from other types of thyroid cancer based on clinical features alone. Average age at diagnosis is greater than patients with PTC. Accurate diagnosis is critical as it requires a different approach than other types of thyroid cancer, it may require a different surgical approach, and may benefit from targeted therapy. Therefore, knowledge of the cytomorphology of MTC is essential for accurate diagnosis and optimal patient care.
An efficient repeat masking library for the genomic data of coconut and related trees
Authors: Prasad Shri Hari , Mathew Deepu , Valsalan Ravisankar
Published: July 2023

Even though repeat masking using custom designed libraries significantly improves the genome annotation and gene prediction, such libraries for palm trees are yet to be designed and made accessible to the researchers. In this study, a repeat library was designed and validated for use in coconut and related palm genomes. Coconut genome with chromosome-level assembly was used to design independent libraries for tall and dwarf ecotypes, which were subsequently merged. Efficiency of the combined de novo library in genome annotation and gene prediction was assessed in comparison with the conventional libraries (Dfam+RepBase), using RepeatMasker. De novo library had 76.3 % efficiency in coconut genomes compared to 3.51 % in custom libraries and number of genes predicted was reduced from an average of 193,099 to 31,022. In date palm, oil pam and sago palm also, combined library gave higher repeat masking and reduced the number of genes predicted. The de novo library can be accessed at http://www.kau.in/repeat-libraries.
SNPs Detection and Genetic Analysis of Chionanthus retusus via Genotyping-by-Sequencing
Authors: Huang Song , Zheng Wei , Liang Xiangpeng , Duan Qingda , Wang Juan , Sun Yaoqing , Ma Tianxiao
Published: July 2023

Chionanthus retusus is one of the well-known ornamental trees in East Asia and America. Not only its value in the market but also had the potential as a source for producing antioxidant. However, due to uncontrolled exploitation, the number of wild C. retusus in China is decreasing rapidly. The genetic study of C. retusus is limited. In order to investigate the genetic diversity and the distribution of C. retusus in China, 47 samples from 8 different provinces have been sequenced via restriction site-associated DNA sequencing (RAD-seq). Totally, 31, 402 high-quality single nucleotide polymorphisms (SNP) were obtained. According to the phylogenetic tree and the principal component analysis, the samples were divided into four populations, including 3 major populations and 1 hybrid population. Population1 were the samples from Jiangsu and Yunnan province and the Population2 were mainly from northern and northeast of China including Liaoning and Hubei province, while the Population4 were from Shandong and Henan province, which were in central China. As the admixture showed, the population3 were the offspring of the other 3 populations by hybridization. The mean heterozygosity of Chinese Fringe tree from different province is 0.42 %, with the highest heterozygosity, which is as high as 0.63 %, from Jiangsu province and the lowest heterozygosity, which is only 0.19, from Henan province. This is the first report about the genetic diversity and relationship of Chionanthus retusus, which will provide value information for further genetic study, genomic study, conservation and breeding.
SNPscan breeder – a computer program to test genomic tools in breeding programs
Authors: Degen Bernd , Müller Niels A.
Published: July 2023

SNPscan breeder is a software that enables the simulation of breeding programs using simulated individual whole genome data, different genetic architectures of a trait of interest, different mating designs and different selection criteria, i.e. pheno-types, breeding values from progeny tests, marker-assisted selection (MAS) and genomic selection (GS). The impact of breeding population size, mating design, selection intensity, genetic architecture, heritability and selection criteria on genetic gains, kinship, inbreeding and genetic diversity can be evaluated to optimize the breeding program. A special feature is the possibility for post-hoc analysis of different strategies to identify causal SNPs and allele effects within the frame of genome-wide association studies (GWAS). The proportion of true and false positive SNPs and the correlation of estimated and true allelic effects can be measured and the overall impact of their use for MAS on the success of the breeding program can be tested.
Riparian Invasive Alien Plant Species in Southern Transylvania (Romania): History of Introduction, Chorology and Ecology
Authors: Danci Oana , Drăgulescu Constantin
Published: July 2023

The establishment and spread of invasive alien plant species (IAPS) outside their natural habitats have irreversibly affected native biodiversity in almost every habitat type.

For Southern Transylvania, we recognise that there are about 200 adventive plants. From those, we selected 18 IAPS that occupy riparian habitats, the most common, abundant, frequent or with higher impact on habitats and human health. We studied the history of their introduction in the study area, their distribution paths and means of spreading in the wild, their chorology and ecology.
An Evaluation of the Success and Failure of Traps Designed for Exotic Sea Snail (Rapana venosa) Fishing Located on the South-Eastern Black Sea Coast
Authors: Zengin Mustafa , Süer Serdar , Rüzgar Melih , Üzer Uğur
Published: July 2023

Research trials were carried out in the Samsun shelf region, where snail fishing is most common, in summer and autumn. The design of the net in the trap trials was inspired by the model used in South Korea. In the trials, the traps were kept in the sea for 24, 48, and 72 hours. According to the findings, an average of 0.31, 0.13, and 0.10 kg/day/basket were caught in the summer period, and an average of 0.15, 0.06, and 0.04 kg/day/basket in the fall for all three holding periods, respectively. In terms of catch per unit effort (CPUE) compared to the traditional beam trawler, economically satisfactory results could not be obtained.
Distribution of Macrobrachium nipponense (De Haan, 1894) (Decapoda, Palemonidae) in the Republic of Moldova
Authors: Munjiu Oxana , Şuberneţkii Igori , Bulat Dumitru , Bulat Denis , Toderaş Ion
Published: July 2023

Data on the distribution, abundance, biomass, and morphological features of Macrobranchium nipponense from 1986-2022 collected in the Republic of Moldova are presented. Maximum length of Macrobrachium nipponense was 117 mm, which is bigger than in other places, maximum weight was 13.8 g. The highest abundance was 12 individuals/m2. M. nipponense dispersed from the place of introduction on a distance of 210 km. The most probable pathways of dispersal are the natural spread in the rivers, and unintentional or intentional introduction by fishponds owners in isolated ponds. Since 1986 M. nipponense population on our territory became tolerant to low winter temperatures of water 0.2°С-2.5 С, this fact also contributed to extension of their area and in the neighboring countries water bodies.
Differences in Growth Pattern in Two Freshwater Fish Species (Leuciscidae) During Summer Drought in North-West Italy
Authors: Virga Gianmarco , Arnieri Fabrizio , Costantino Matteo
Published: July 2023

This study aim is to assess how the water shortage impacted on the growth of two endemic freshwater fish species, the Italian riffle dace Telestes muticellus (Bonaparte, 1837) and Phoxinus spp. complex, in a pre-alpine area in North-West Italy. Both species’ specimens growth depended on the streamflow rate: in particular low water levels weighted on Phoxinus spp. specimens, since they showed a negative growth pattern during dry months, while the Telestes muticellus ones continually had a positive growth pattern in the same time frame. The streamflow rate plays a key role in fish growth during severe drought in this area but mechanisms that allow Telestes muticellus specimens to outcompete Phoxinus spp. ones throughout water shortage periods are still unknown.
Natura 2000 A Panacea? Natura 2000 Site Oltul Mijlociucibin-Hârtibaciu (ROSCI0132) ‒ a Local Extinction of a Native Fish Species and a New Alien Fish Arrival Case Study
Authors: Bănăduc Doru , Bakhshalizadeh Shima , Curtean-Bănăduc Angela
Published: July 2023

The Romanian Oltul Mijlociu-Cibin-Hârtibaciu Natura 2000 site of community importance (SCI) was designated for the purpose of protecting biodiversity and maintaining the wild flora and fauna in a favourable conservation status, as well as the natural habitats of conservation interest. This research focused on the possible disparition of one protected fish species Pelecus cultratus (Linnaeus, 1758) and the appearance of an alien one Babka gymnotrachelus (Kessler, 1857), as ecological indicators of the fact that at least this Natura 2000 site is far from being properly protected and a new, more responsible way should be followed and different administrators put in charge of the areas management.
Analysis of the kinetic path of some physical measurements and kinetic abilities in terms of the direct attack in the foil
Authors: Aziz Rita , Al-Haddad Noor
Published: July 2023

Through the researchers' acquaintance with the previous studies, the problem was identified as that the preparation of training curricula in all its units must be based on accurate scientific foundations. Positively affect the type of attack and its implication in the presence of correlational relations, whether direct or indirect, i.e., precedence in training and in preparing units Therefore, the researcher decided to build a causal model to know the relationships to show the best model of the direct straight attack. The study aimed to build a causal model for the most important physical measurements and kinetic capabilities of the direct straight attack in the research sample. The two researchers used the descriptive approach in the manner of causal relationships, so the two researchers conducted the experiment on a sample of the second stage students, whose number is (85) students out of (109) students, and they were chosen according to the equation. Stephen Sampson After conducting the exploratory experiment and performing the measurements and tests of the research, they were classified and treated statistically, so they conclude the validity of the causal model in stating the precedence of the variables.
Building a battery to measure some physical indicators as an indicator for evaluating female students aged (16-18) years in Tikrit district
Authors: Karim Taha , Rashid Faten
Published: July 2023

The study aims to:

- Building arak sensory-motor tests for some basic badminton skills for (advanced) players.

- Codification of arak sensory-motor tests of some basic badminton skills for (advanced) players.

      The researcher used the descriptive approach in a survey method for its suitability and the nature of the problem, and the research community included the badminton players of the Iraqi Premier League badminton clubs in the 2020-2021 season, and they numbered 52 players and Based on the requirements for building and legalizing the tests under study, the sample was divided into an exploratory sample of (2) players, a construction sample of (12) players, and a sample of the main experiment of (35) players, and (3) players were excluded because they are participants with the Iraqi team Badminton in external tournaments, and after viewing the specifications of the vocabulary of each testThe apparent honesty, subjective honesty, hypothetical honesty (veracity of discrimination), verification of objectivity, difficulty and ease of tests, finding stability coefficients to reach the final version of each test and experimenting with it exploratory and after completing these steps according to the determinants of measurement and evaluation in physical education sciences, the researcher deliberately On applying it to the main experiment sample (rationing), and processing the results of the spss social statistical bag to derive the criteria for each test. The researcher concluded that the perceptual-kinesthetic tests of some basic badminton skills for (advanced) players measure the purposes for which they were designed and are appropriate for their level, age and the specialized game and are characterized by ease of application and low financial cost and do not require many devices or tools. Perception - kinesthetics of some basic badminton skills for advanced players that have been built, The researcher recommends that it is necessary to rely on the perceptual-kinesthetic tests of some basic skills in badminton when evaluating the players, and the need to follow the systematic sequential steps according to the determinants of measurement and evaluation in physical education sciences and sports sciences when constructing or modifying perceptual-motor tests, and conducting studies Similar on larger or different samples (age and gender), and conducting similar studies by adopting the steps of this study to build tests in games and other sporting events, and to benefit from this test when developing training programs and selecting players to serve this game.
Izmir Earthquake Experience of Healthcare Professionals During Pandemics: A Qualitative Study
Authors: DÜZGÜN Gönül , POLAT Gökşen , HAKVERDİOĞLU YÖNT Gülendam , ŞENUZUN AYKAR Fisun
Published: July 2023

Introduction: During the period where the effects of Covid-19 pandemics have been intensively experienced, a 6.9 magnitude earthquake struck off İzmir province, resulting in devastating consequences. The earthquake during pandemics cause to increase work overload to healthcare professionals, leading to additional challenges in the management of the process. Aim: This is phenomenological research conducted to depict experiences and practices of healthcare professionals who experienced an earthquake together with pandemics. Materials and Methods: The study was conducted with 11 healthcare professionals working in the emergency department of a private healthcare facility in İZMİR. The data were collected using a semi-structured, online interview. Results: Overall, 3 primary and 18 sub-themes were revealed regarding the experiences and practices of the nurses. Most participants experienced emotions such as fear, shock, panic, and sadness at the time of the earthquake and when faced with earthquake victims. They experienced shortness in resources, safety concerns for themselves and their families as well as health issues and their management. Conclusion and suggestions:Participants reported that knowledge regarding competence in the profession, communication skills, ingenuity, and innovation in providing care due to shortness of resources, professional, triage, to provide psychological care, and follow-up skills are required in this challenging. Highlights: During disasters, healthcare professionals work in difficult conditions with limited resources and face problems and difficulties more than those experienced during their daily practice. This study presents very important information about health professionals' need to support not only the organization but also psychological support when is been living more than one disaster.
Long-term use of glucocorticoids in patients with active rheumatoid arthritis: therapeutic "freeze frame"
Authors: Gordeev Andrey V. , Matyanova Elena V. , Galushko Elena A.
Published: July 2023

Background. In Russia, as well as throughout the world, the use of glucocorticoids (GC) in the treatment of rheumatoid arthritis (RA) is widespread, often going beyond the recommendations for both duration and dose regimen, which makes it relevant to study the long-term consequences of such a wrong (EULAR, 2022) use of GC in RA therapy.
Materials and methods. Of 1143 patients with active RA (ACR/EULAR 2010), two groups were formed: A (n=782) RA patients with more than 6 months of experience with systemic GC; group B (n=245) no experience of taking GC. The cumulative disease index (CIRS) was used to assess the comorbidity profile.
Results. Patients in group A were older (p0.0001), with a longer duration of RA (p=0.0004) and more often with IV radiological stage (p=0.02). With comparable (DAS28) RA activity, the D2T variant of RA was more often detected in them (p=0.036). RA therapy in group A was characterized by a large number of used disease-modifying anti-rheumatic drugs (p=0.0003), more frequent development of methotrexate-induced hepatitis (p=0.03). In group A, the time interval between the onset of RA and the initiation of biological therapy was longer (p=0.0001) and directly correlated with the duration of GC therapy (Rs=0.38) with a comparable qualitative structure of the used b/tsDMARDs. In the same group, tuberculosis, hypertension, chronic kidney disease, cataract and osteoporosis (p0.05) and its complications were diagnosed significantly more often with a comparable frequency of cardiovascular disease, diabetes, and gastrointestinal lesions. In group A, a higher CIRS multimorbidity index was detected, and the CIRS severity index was lower than in group B (p0.05).
Conclusion. Long-term use of GC did not lead to a decrease in disease activity, inhibition of radiographic progression, delayed the timely administration of b/tsDMARDS and was accompanied by an increase in the multimorbid load.
A new integral enthesial-comorbididity index of psoriatic arthritis activity
Authors: Korsakova Yulia L. , Korotaeva Tatiana V. , Loginova Elena Yu. , Gubar Elena E. , Vorobyeva Lyubov D. , Glukhova Svetlana I. , Nasonov Evgeny L.
Published: July 2023

Aim. To develop an integral index of psoriatic arthritis (PsA) activity.
Materials and methods. 117 patients with PsA (M/F 63/54) were included. Patients age 4411 years, psoriasis (Ps) duration 213153 months, PsA duration 73.478.5 months. Patients underwent standard clinical examination of PsA activity: tender (out of 68) and swollen (out of 66) joint counts (TJC, SJC), LEI, tenderness of the plantar fascia (PF), skin lesion severity (BSA), presence of nail Ps, body mass index (BMI), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), DAPSA, FACIT-F. Parametric and nonparametric statistic methods, correlation and ROC analysis were used.
Results. Mean DAPSA was 3821, TJC 14.210.6, SJC 10.68.3, ESR 30.529.5 mm/h, CRP 23.329 mg/l, LEI 1.21.5, FACIT-F 3211, BMI 27.46.2 kg/m2. The following significant positive correlations were revealed: between DAPSA and BMI, patients age, ESR, PsA and Ps duration, TJC, SJC, LEI, presence of PF enthesitis, skin lesion severity, presence of nail Ps. A negative correlation between FACIT-F and male sex was found. Based on the predictive model of parameters, the Entesial-Comorbid Index of PsA (ECIPsA) was created: 3.81LEI+13.72PF+0.54Age-0.25FACIT-F+7.36BSA+7.94PsA duration+5.5Nail Ps+0.32BMI-3.52, namely LEI Leeds Enthesial Index; PF pain in the PF; patients age; FACIT-F fatigue scale; BSA3%=0, 3%=1; PsA duration2 years=0, 2 years=1; presence of nail Ps=1, absence=0; ECIPsA28 corresponds with high PsA activity according to DAPSA28. ROC analysis of sensitivity and specificity of the prognostic model demonstrated high correctness of the index: the area under the ROC curve was 0.768, 95% confidence interval (0.6240.913).
Conclusion. The new PsA activity index corresponds to the existing ones and takes into consideration the clinical heterogeneity and comorbidity of the disease.
AL amyloidosis mimicking IgG4-related disease: case report
Authors: Chaltsev Bogdan D. , Torgashina Anna V.
Published: July 2023

The article describes a unique clinical case of AL amyloidosis mimicking IgG4-related disease. Plasma cell dyscrasias can mimic clinical and laboratory manifestations of rheumatic diseases, which can lead to a delay in diagnosis and inappropriate therapy.
Diastolic dysfunction of ventricles in patients with calcium pyrophosphate crystal deposition disease while receiving anti-inflammatory therapy
Authors: Eliseev Maxim S. , Zheliabina Olga V. , Kirillova Irina G. , Korsakova Yulia O.
Published: July 2023

Background. Calcium pyrophosphate crystal deposition disease (CPPD) may be associated with developing of diastolic dysfunction (DD).
Aim. To determine the variability of echocardiographic parameters in patients with CPPD receiving anti-inflammatory therapy.
Materials and methods. Twenty six patients with CPPD and osteoarthritis (OA) from 18 to 65 years old were included in the case-control study. All patients underwent echocardiography, laboratory parameters at baseline and after 6 months. Patients with CPPD received methotrexate 15 mg per week or hydroxychloroquine 200 mg once a day, or colchicine 1 mg per day. Diastolic function according to echocardiography was assessed.
Results. Diastolic dysfunction was detected in 19 patients: in 11 (42%) patients with CPPD and 8 (31%) patients with OA (p=0.39). The baseline serum CRP level was higher in the CPPD group (p=0.03), no differences were found for other indicators. Twenty-two patients with CPPD and 19 patients with OA completed the study. In patients with OA, there were no significant changes in indicators reflecting the diastolic function of ventricles.
Conclusion. CPPD therapy with colchicine, hydroxychloroquine and methotrexate has a positive effect on indicators of diastolic ventricular function.
Physical activity and nutritional status in women with rheumatoid arthritis and sarcopenic phenotype of body composition
Authors: Dobrovolskaya Olga V. , Feklistov Alexey Yu. , Demin Nikolay V. , Kozyreva Maria V. , Toroptsova Natalia V.
Published: July 2023

Aim. To assess physical activity (PA) and nutritional status and their relationship with the sarcopenic phenotype of body composition in women with rheumatoid arthritis (RA).
Material and methods. 104 women (mean age 59.58.7 years) with RA underwent clinical and laboratory examination, dual-energy X-ray absorptiometry. The level of PA and nutritional status were assessed using the International Physical Activity Questionnaire (IPAQ) and Mini Nutritional Assessment (MNA) questionnaires, respectively.
Results. Sarcopenic phenotype was diagnosed in 37.1% of patients. Moderate and low PA levels were detected in 44.2 and 7.8%, respectively, risk of malnutrition in 50% of persons. In multivariate logistic regression analysis, factors associated with the sarcopenic phenotype were determined: the frequency of vigorous PA3 times a week [odds ratio OR 5.12 (95% confidence interval CI 1.1522.94); p=0.032], walking 1 hour a day [OR 4.98 (95% CI 1.1421.74); p=0.033], risk of malnutrition by MNA [OR 4.13 (95% CI 1.1215.32); p=0.034], body mass index 25 kg/m2 [OR 8.11 (95% CI 1.8635.32); p=0.006] and daily calcium intake 500 mg [OR 4.62 (95% CI 1.0620.08); p=0.041].
Conclusion. 52% of women with RA had moderate оr low PA levels, and 50% of patients were at risk of malnutrition. The risk of sarcopenic phenotype associated with a low frequency of vigorous PA, low walking time, risk of malnutrition, body mass index 25 kg/m2 and insufficient calcium intake.
Mental disorders in patients with systemic lupus erythematosus: association with activity and the course of rheumatic disease
Authors: Borisova Anastasia B. , Lisitsyna Tatiana A. , Veltishchev Dmitry Yu. , Reshetnyak Tatiana M.
Published: July 2023

Aim. To clarify the relationship between the clinical and psychopathological features of mental disorders, clinical and laboratory manifestations of activity and the nature of the course of systemic lupus erythematosus (SLE).
Materials and methods. The study included 119 patients 98 (82.4%) women, mean age 36.512.4 years (MSD) with a reliable diagnosis of SLE (EULAR/ACR 2019 criteria), 51 (29.5%) of them with secondary antiphospholipid syndrome APS (International criteria of 2006).
Results. Among patients with SLE a high frequency of anxiety-depressive spectrum disorders (ADSD) and cognitive impairment (CI) was revealed. There was an association of greater severity of depression with high SLE activity index, acute/subacute onset of the disease course according to the classification of V.A. Nasonova, relapsing-remitting and chronic active current disease activity patterns of SLE according to the classification of S. Barr M. Petri. Anxiety disorders were associated with subacute onset and relapsing-remitting disease activity patterns of SLE and were not associated with SLE activity index. Bipolar disorder was detected more often in patients with chronic SLE. Acute psychosis/delirium was associated with acute onset of SLE. Organic CI was associated with APS, chronic onset and long quiescent disease activity patterns of SLE. The episindrome and schizotypal disorder in patients with SLE are more often caused by concomitant APS.
Conclusion. Patients with high SLE activity index should be of particular concern to rheumatologists regarding the diagnosis of depressive disorders. Patients with concomitant APS need timely diagnosis and treatment of CI and episindrome in order to improve the prognosis of the disease and the overall quality of life.
The structure of post/long COVID fatigue syndrome. Prospects for correction
Authors: Kuznetsova Polina I. , Tanashyan Marine M. , Raskurazhev Anton A. , Zaslavskaya Kira Ia.
Published: July 2023

Aim. To study the features of post-COVID asthenic syndrome and evaluate the effectiveness of the drug containing the succinic acid complex with trimethylhydrazinium in its treatment.
Materials and methods. A prospective, multicenter, comparative, randomized, double-blind, placebo-controlled study of the efficacy of sequential therapy with BRAINMAX included 160 patients with a history of coronavirus infection within 12 to 16 weeks (not more than 12 months). The study was conducted at 6 healthcare centers in different regions of the Russian Federation. Testing was performed on the following scores: VAS for headache score, MFI-20 asthenia score, PSQI test, FAS-10 fatigue score, DHI dizziness score, MoCA cognitive impairment score, Beck anxiety score, vegetative index of Kerdo.
Results. PSQI questionnaire showed significant improvement in sleep quality in the study group: by -2.5 points [-4; -1] (p0.001); there was a more pronounced significant decrease in the MFI-20 score of -19.5 points [-27; -11] (p0.001); a significant decrease in the FAS-10 fatigue score by -9 [-13.5; -4] points (p0.001); DHI dizziness score showed a decrease by -6 [-12; 0] points in the BRAINMAX group (p=0.001); the score of Beck anxiety and depression scale decreased by -5 [-11; -2] points (p0.001). Multiple linear regression data showed a significant increase of 0.56 (p=0.02) in the MoCA score.
Conclusion. Our study convincingly showed the effectiveness of therapy with BRAINMAX in a wide range of symptoms in patients with the post-COVID syndrome.
Structural and functional characteristics of the brain and their role in the development of eating behaviour in obesity: A review
Authors: Samoilova Iuliia G. , Podchinenova Daria V. , Matveeva Mariia V. , Kudlay Dmitry A. , Oleynik Oxana A. , Tolmachev Ivan V. , Kaverina Irina S. , Vachadze Tamara D. , Kovarenko Margarita A. , Loginova Olga A.
Published: July 2023

Obesity is a major public health problem that requires new approaches. Despite all interventions, the behavioural and therapeutic interventions developed have demonstrated limited effectiveness in curbing the obesity epidemic. Findings from imaging studies of the brain suggest the existence of neural vulnerabilities and structural changes that are associated with the development of obesity and eating disorders. This review highlights the clinical relevance of brain neuroimaging research in obese individuals to prevent risky behaviour, early diagnosis, and the development of new safer and more effective treatments.
Systemic lupus erythematosus and antiphospholipid syndrome: past, present, future
Authors: Nasonov Evgeny L. , Reshetnyak Tatiana M. , Solovyev Sergey K. , Popkova Tatiana V.
Published: July 2023

Immune-inflammatory (autoimmune and autoinflammatory) rheumatic diseases are widespread severe chronic inflammatory diseases and also models for studying the fundamental mechanisms of pathogenesis and approach to pharmacotherapy of other diseases associated with autoimmunity and/or autoinflammation. Uncontrolled inflammation leading to hypercoagulation forms the basis of thromboinflammation, which is considered a universal pathogenetic mechanism of organ involvement in immune-inflammatory rheumatic diseases, as well as in COVID-19 and atherosclerotic vascular lesions (atherothrombosis). Thrombo-inflammatory mechanisms play a crucial role in systemic lupus erythematosus and antiphospholipid syndrome. Russian rheumatology, under the leadership of academician Valentina Alexandrovna Nasonova, greatly contributed to the research of these disorders. This article addresses the current view about the overlapping pathogenetic mechanisms of thrombosis in systemic lupus erythematosus and antiphospholipid syndrome, the relevance of these studies during the COVID-19 pandemic, and the prospects for antithrombotic and anti-inflammatory therapy.
The use of sodium hyaluronate to treat upper limb disease: A review
Authors: Filatova Yulia S. , Ilyin Mikhail V.
Published: July 2023

The most common diseases of the upper limb are osteoarthritis (OA) of the joints of the hands, lateral epiconlitis, tendinitis of the shoulder muscles, adhesive capsulitis. OA of the shoulder and acromioclavicular joints is less common. The development of acute and subacute pain in the elbow and shoulder joints in the vast majority of cases is determined by the pathology of soft tissues: muscles, ligamentous apparatus and related synovial bags, making it difficult to diagnose. A clinical and radiological heterogeneity of OA of the joints of the hands is a very complex pathology for the study, and also to create a unified algorithms for therapy. Therapy nonsteroidal anti-inflammatory drugs are effective in the short term, but it has several side effects. Despite a variety of attempts at therapy with successful and unsuccessful outcome, the attention of researchers for several decades converted to the injection therapy with hyaluronic acid. The article presents the data of studies demonstrating the anti-inflammatory effect of hyaluronic acid in the treatment of OA, as well as the results of clinical trials and data system of meta-analysis demonstrating the effectiveness of intra-articular and extra-articular therapy tendinopathy of the upper limb. Most of the cited studies demonstrated the efficacy and good tolerance of 1% sodium hyaluronate. In the domestic market it is presented in the drug Flexotron Forte. The authors provide the results of the study results, demonstrating the efficacy and safety of using Flexotron Forte to clinical practice.
Formulation and Evaluation of Transdermal Patches of Clotrimazole
Authors: Jagadeesh Yelamanda
Published: July 2023

The aim of the present research work was to formulate Transdermal patches of Clotrimazole and to enhance effectiveness and to avoid side effects of the drug. Transdermal patch of clotrimazole was prepared with EC and HPMC in different ratios in order to improve the drug diffusion. Clotrimazole has formulated Transdermal patches were prepared by solvent evaporation technique. Drug and polymers has been characterized by FT-IR. The FTIR spectra of formulation shows that no interaction between drug and excipient. The evaluation of Transdermal patches of Clotrimazole were performed mainly for their Physical parameters such as Weight variation, Thickness, Folding endurance test And also for their Drug content and In-vitro Drug diffusion studies. The patch prepared by solvent evaporation technique passes the prepared patch were found to be non irritant, weight variation was found in the range of 39±5.81 to 48±2.90mg, thickness in the range of 0.08±0.09 to 0.04±0.08 mm, Folding endurance of patches was found to be in the range of 98 ±0.57 to 128±0.59, The tensile strength of the patches was ranging from 1.95±1.2to 3.98±1.9, The percentage elongation ranges from 10.6 to 18.6, drug content uniformity was in between 78.25 to 89.76 %. The in-vitro drug diffusion profiles of the formulations in pH 7.4 show differences depending on their composition. A Tran’s dermal patches of all the preparations were observed by the diffusion test. It was also observed that F6 showed highest drug release.