bluuebunny/crossref_metadata_2025 huggingface dataset:
Developing home cleaning intervention through community engagement to reduce infections and antimicrobial resistance in Ghanaian homes
Authors: Tsekleves Emmanuel , de Souza Dziedzom , Pickup Roger , Ahorlu Collins , Darby Andy
Published: June 2023

Globally Antimicrobial Resistance (AMR) constitutes a health crisis, particularly in developing countries, where infectious disease are commonly fatal. There is clear evidence for microbial exposure and infection transmission within the home. Personal and environmental hygiene are the best ways of reducing household infections thus decreasing the need for antibiotics and consequently diminishing AMR. Despite this being an obvious step, research efforts to understand the home environment and its impact on AMR, cleaning and possible interventions on household cleaning are limited. We combined design and microbiology methods in an innovative mixed-method approach. A traditional survey design (n = 240), a design ethnography (n = 12), a co-design workshop and a pre-intervention microbiological dust sample analysis was undertaken to provide insights for codesign workshops in which new cleaning practices might be developed to minimise any AMR bacteria present in the household environments located in the Greater Accra Region of Ghana. Microbiological analysis of household dust showed that 36.6% of bacterial isolates detected were found to carry at least one resistance to the panel of antibiotics tested. Four scenarios were generated from an economic segmentation of the survey data. 50 ethnographic insights were ‘presented’ and descriptions of 12 bacteria species that showed resistance to one or more antibiotics (representing 176 bacterial isolates that showed resistance to one or more antibiotics found in the dust samples) were presented to the participants in a codesign workshop. An intervention, a new regime of cleaning practices agreed through the co-design workshop and practiced for thirty days, was made in (n = 7) households. The high prevalence of multidrug resistance observed in this study indicate the need for antibiotics surveillance program, not only in hospital settings but also in the household environment. There is, thus, an urgent need for targeting of interventions at the household level. Activating knowledge through community engagement in the research helps in increasing public perception and breaking down the scientist-public barrier.
A novel approach based on neutrosophic Bonferroni mean operator of trapezoidal and triangular neutrosophic interval environments in multi-attribute group decision making
Authors: Nagarajan D. , Kanchana A. , Jacob Kavikumar , Kausar Nasreen , Edalatpanah Seyyed Ahmad , Shah Mohd Asif
Published: June 2023

Neutrosophic multicriteria is a method of decision-making that uses indeterminacy to combine several criteria or elements, frequently with incomplete or ambiguous information, to find a solution. The neutrosophic multicriteria analysis enables the assessment of qualitative and subjective aspects and can assist in resolving conflicting goals and preferences. In the Neutrosophic Multi-Attribute Group Decision Making (NMAGDM) problems, all the information provided by the decision makers (DMs) is expressed as single value neutrosophic triangular and trapezoidal numbers examined in this study which can provide more flexibility and accuracy in capturing uncertainty and aggregating preferences. We offer a novel approach for determining the neutrosophic possibility degree of two and three trapezoidal and triangular neutrosophic sets and the concepts of neutrosophic possibility mean value. The trapezoidal and triangular neutrosophic Bonferroni mean (TITRNBM) operator and the trapezoidal and triangular neutrosophic weighted Bonferroni mean (TITRNWBM) operator are two aggregation methods we then create. Further, we examine the TITRNBM and TITRNWBM attributes and their uniqueness. The NMAGDM approach with trapezoidal and triangular information is suggested based on the TITRNWBM operator and possibility degree. Finally, a concrete example of manufacturing companies searching for the best supplier for assembling the critical parts is provided to validate the established strategies and show their practical applicability and efficacy.
Conflicting findings on the effectiveness of hydrogen therapy for ameliorating vascular leakage in a 5-day post hypoxic-ischemic survival piglet model
Authors: Htun Yinmon , Nakamura Shinji , Nakao Yasuhiro , Mitsuie Tsutomu , Ohta Kenichi , Arioka Makoto , Yokota Takayuki , Inoue Eri , Inoue Kota , Tsuchiya Toi , Koyano Kosuke , Konishi Yukihiko , Miki Takanori , Ueno Masaki , Kusaka Takashi
Published: June 2023

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of morbidity and mortality in newborns in both high- and low-income countries. The important determinants of its pathophysiology are neural cells and vascular components. In neonatal HIE, increased vascular permeability due to damage to the blood–brain barrier is associated with seizures and poor outcomes in both translational and clinical studies. In our previous studies, hydrogen gas (H2) improved the neurological outcome of HIE and ameliorated the cell death. In this study, we used albumin immunohistochemistry to assess if H2 inhalation effectively reduced the cerebral vascular leakage. Of 33 piglets subjected to a hypoxic-ischemic insult, 26 piglets were ultimately analyzed. After the insult, the piglets were grouped into normothermia (NT), H2 ventilation (H2), therapeutic hypothermia (TH), and H2 combined with TH (H2-TH) groups. The ratio of albumin stained to unstained areas was analyzed and found to be lower in the H2 group than in the other groups, although the difference was not statistically significant. In this study, H2 therapy did not significantly improve albumin leakage despite the histological images suggesting signs of improvement. Further investigations are warranted to study the efficacy of H2 gas for vascular leakage in neonatal HIE.
Ribosome biosynthesis and Hedgehog activity are cooperative actionable signaling mechanisms in breast cancer following radiotherapy
Authors: Metge Brandon J. , Alsheikh Heba A. , Chen Dongquan , Elhamamsy Amr R. , Hinshaw Dominique C. , Chen Bo-Ruei , Sleckman Barry P. , Samant Rajeev S. , Shevde Lalita A.
Published: June 2023

Hyperactivated ribosome biosynthesis is attributed to a need for elevated protein synthesis that accommodates cell growth and division, and is characterized by nucleomorphometric alterations and increased nucleolar counts. Ribosome biogenesis is challenged when DNA-damaging treatments such as radiotherapy are utilized. Tumor cells that survive radiotherapy form the basis of recurrence, tumor progression, and metastasis. In order to survive and become metabolically revitalized, tumor cells need to reactivate RNA Polymerase I (RNA Pol I) to synthesize ribosomal RNA, an integral component of ribosomes. In this study, we showed that following radiation therapy, tumor cells from breast cancer patients demonstrate activation of a ribosome biosynthesis signature concurrent with enrichment of a signature of Hedgehog (Hh) activity. We hypothesized that GLI1 activates RNA Pol I in response to irradiation and licenses the emergence of a radioresistant tumor population. Our work establishes a novel role for GLI1 in orchestrating RNA Pol I activity in irradiated breast cancer cells. Furthermore, we present evidence that in these irradiated tumor cells, Treacle ribosome biogenesis factor 1 (TCOF1), a nucleolar protein that is important in ribosome biogenesis, facilitates nucleolar translocation of GLI1. Inhibiting Hh activity and RNA Pol I activity disabled the outgrowth of breast cancer cells in the lungs. As such, ribosome biosynthesis and Hh activity present as actionable signaling mechanisms to enhance the effectiveness of radiotherapy.
MoOx-decorated Ru/TiO2 with a monomeric structure boosts the selective one-pot conversion of levulinic acid to 1,4-pentanediol
Authors: Rodiansono  , Azzahra Atina Sabila , Dewi Heny Puspita , Adilina Indri Badria , Sembiring Kiky Corneliasari
Published: June 2023

Molybdenum oxide-decorated Ru/TiO2 with a monomeric structure boosts the selective one-pot conversion of levulinic acid to afford a high yield of 1,4-PeD (91%) at 110 °C and 40 bar H2 for 6 h.
Selective halogenation of central and end-units of nonfullerene acceptors enables enhanced molecular packing and photovoltaic performance
Authors: Xie Meiling , Shi Yanan , Zhu Lingyun , Zhang Jianqi , Cheng Qian , Zhang Hao , Yan Yangjun , Zhu Mingquan , Zhou Huiqiong , Lu Kun , Wei Zhixiang
Published: June 2023

Qx-p-4Cl with both apara-fluorinated central unit and chlorinated end groups exhibits enhanced molecular packing, facilitating efficient charge transport, and thus achieving a power conversion efficiency (PCE) of 18.78% when blended with donor PM6.
Overall performance improvement of direct-current triboelectric nanogenerators by charge leakage and ternary dielectric evaluation
Authors: Li Qianying , Fu Shaoke , Li Xiaochuan , Chen Huilin , He Wencong , Yang Qianxi , Zhang Xuemei , Yang Huake , Ren Dahu , Xi Yi
Published: June 2023

By coupling the charge leakage effect and the ternary dielectric triboelectrification effect, our work improves the overall performance of DC-TENGs and creates new records in average power density, peak factor and output charge density.
Metabolism disturbance by light/dark cycle switching depends on the rat health status: the role of grape seed flavanols
Authors: Soliz-Rueda Jorge R. , López-Fernández-Sobrino Raúl , Torres-Fuentes Cristina , Bravo Francisca I. , Suárez Manuel , Mulero Miquel , Muguerza Begoña
Published: June 2023

Changes in light/dark cycles and obesogenic diets are related to metabolic disorders.
Compositional and functional features of the intestinal lactobacilli associated with different long-term diet types
Authors: Yi Shanrong , Zhang Chengcheng , Yin Pingping , Yu Leilei , Tian Fengwei , Chen Wei , Zhai Qixiao
Published: June 2023

Meta-analysis of the effects of diet types on the compositional and the function of lactobacilli in the gut, demonstrating omnivorous diet increased the abundance of L. ruminis, while lactobacilli under vegetarian diet showed more special functions.
Zinc oxide nanoparticles embedded photo-crosslinkable PLA-block-PEG toward effective antibacterial coatings
Authors: Maity Nabasmita , Bruchiel-Spanier Netta , Sharabani-Yosef Orna , Mandler Daniel , Eliaz Noam
Published: June 2023

A novel photo-crosslinkable, biocompatible, fouling resistant, UV-assisted coating composed of ZnO nanoparticles in methacrylate end-terminal PLA-block-PEG copolymers for combatting implant-associated infections.
3D multicellular micropatterning biomaterials for hair regeneration and vascularization
Authors: Ma Jingge , Qin Chen , Wu Jinfu , Zhuang Hui , Du Lin , Xu Jinfu , Wu Chengtie
Published: June 2023

The magnesium silicate (MS) nanospheres-incorporated 3D multicellular micropatterns that mimic the structure of vessel networks and hair follicles are developed to reconstruct vasculature and hair growth for functional skin regeneration.
Tumor-targeted dual-action NSAID-platinum(iv) anticancer prodrugs
Authors: Kastner Alexander , Mendrina Theresa , Bachmann Florian , Berger Walter , Keppler Bernhard K. , Heffeter Petra , Kowol Christian R.
Published: June 2023

We investigated the first oxaliplatin(iv) complexes releasing acetylsalicylic acid (aspirin) upon reduction. The albumin-targeted derivative showed distinctly improved antitumor activity compared to asplatin, a recently reported cisplatin(iv) analog.
Efficient photothermal conversion of MXenes and their application in biomedicine
Authors: Lu Haozi , Wang Junhua , Li Huimin , Zhou Wei , Yuan Quan , Liu Song
Published: June 2023

This paper mainly introduces the application of photothermal conversion of MXenes in the biomedical field, including photothermal therapy of tumors, drug delivery, photoacoustic imaging, and antibacterial agents.
Progress of electrocatalytic urea synthesis: strategic design, reactor engineering, mechanistic details and techno-commercial study
Authors: Paul Sourav , Adalder Ashadul , Ghorai Uttam Kumar
Published: June 2023

Green urea synthesis is a novel way to convert N2/NOx and CO2 as compared to the industrial method, which is an expensive and high energy demanding process. Mechanistic insights of urea synthesis are important to increase efficiency of the process.
Electrochemical oxidative radical cascade reactions for the synthesis of difluoromethylated benzoxazines
Authors: Chen Xiang , Jiang Jun , Huang Xiao-Jun , He Wei-Min
Published: June 2023

An efficient electrochemical synthesis of fluoroethylated benzoxazines via oxyfluoromethylation was developed. The broad applicability and general utility were tested and highlighted by the substrate scope and late-stage synthesis.
High-precision zinc isotopic characterization of twenty soil reference materials from China determined by MC-ICP-MS
Authors: Zhai Hua-Ye , Wang Xuan-Ce , Li Chao-Feng , Wilde Simon A. , Li Xiang-Zhong , Xu Bei , Zhang Xian-Liang , Zhang Ping
Published: June 2023

Zn isotopic composition was firstly analyzed in twenty soil reference materials. A powerful new tool for tracing biochemical metal cycling at Earth's surface has been provided.
Mechanism of 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) in controlling microbial problems in aircraft fuel systems
Authors: Yan Xiaohan , Han Ruifang , Fan Weijie , Shan Borong , Yang Jie , Zhao Xiaodong
Published: June 2023

This research investigated the potential use of 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) as a biocide in aircraft fuel systems, which is rarely studied due to the unique properties of such systems.
Boron-based octahedral dication experimentally detected: DFT surface confirms its availability
Authors: Keller Willi , Sárosi Menyhárt B. , Fanfrlík Jindřich , Straka Michal , Holub Josef , McKee Michael L. , Hnyk Drahomír
Published: June 2023

The synthetic efforts and spectroscopic characterization have afforded the first closo-dicationic octahedral phosphahexaborane along with new closo-monocationic pnictogenahexaboranes of the same shapes, whose formation has been DFT-examined.
Impact of residence time distributions in reacting magnesium packed beds on Grignard reagent formation – pump-induced flow behaviour in non-reacting magnesium beds (part 1)
Authors: Deitmann Eva , Maskos Michael , Menges-Flanagan Gabriele , Ziegenbalg Dirk
Published: June 2023

The RTD within a randomly packed bed of non-uniform, non-spherical Mg turnings depends on the properties of the Mg turnings and the pump-induced flow behavior. Using oscillatory flow rates, Bodenstein numbers can be increased by up to 70%.
From energy storage to pathogen eradication: unveiling the antibacterial and antiviral capacities of flexible solid-state carbon cloth supercapacitors
Authors: Beikzadeh Sara , Akbarinejad Alireza , Taylor John , Perera Janesha , Ross Jacqueline , Swift Simon , Kilmartin Paul A. , Travas-Sejdic Jadranka
Published: June 2023

Unleashing the versatility of supercapacitors: Uniting energy storage prowess with post-charging antibacterial and antiviral functionalities.
Central Auditory Processing Dysfunction in Service Members and Veterans: Treatment Considerations and Strategies
Authors: Tepe Victoria , Guillory Lisa , Boudin-George Amy , Cantelmo Tasha , Murphy Sara
Published: June 2023

Purpose:

Military risk factors such as blast exposure, noise exposure, head trauma, and neurotoxin exposure place Service members and Veterans at risk for deficits associated with auditory processing dysfunction. However, there is no clinical guidance specific to the treatment of auditory processing deficits in this unique population. We provide an overview of available treatments and their limited supporting evidence for use in adults, emphasizing the need for multidisciplinary case management and interdisciplinary research to support evidence-based solutions.

Method:

We explored relevant literature to inform the treatment of auditory processing dysfunction in adults, with emphasis on findings involving active or former military personnel. We were able to identify a limited number of studies, pertaining primarily to the treatment of auditory processing deficits through the use of assistive technologies and training strategies. We assessed the current state of the science for knowledge gaps that warrant additional study.

Conclusions:

Auditory processing deficits often co-occur with other military injuries and may pose significant risk in military operational and occupational settings. Research is needed to advance clinical diagnostic and rehabilitative capabilities, guide treatment planning, support effective multidisciplinary management, and inform fitness-for-duty standards. We emphasize the need for an inclusive approach to the assessment and treatment of auditory processing concerns in Service members and Veterans and for evidence-based solutions to address complex military risk factors and injuries.
Apsidal motion in the α CrB binary system revealed through X-ray and optical eclipse timing
Authors: Schmitt J. H. M. M. , Czesla S. , Wichmann R. , Robrade J.
Published: June 2023

The α CrB system is among the brightest known eclipsing binaries in an eccentric orbit. In such systems, the periods between successive primary (Pprim) and secondary minima (Psec) typically differ, and the difference between the two periods provides information on apsidal motion in the system. However, with a binary period of 17.36 days and eclipse durations of more than 8 h, these eclipses are difficult to observe from the ground. We present new photometric observations of primary and secondary eclipses of α CrB obtained with the TESS satellite and we re-examine the available X-ray observations of α CrB at the time of secondary optical minimum. We also combine the optical and X-ray data to determine precise values of Pprim and Psec to explore the consequences for apsidal motion in the α CrB system. We have determined an internal structure constant that is in good agreement with theoretical expectations and we show that there is no need to invoke any substantial misalignment between the rotation and orbital axes of the primary.
Activity time series of old stars from late F to early K
Authors: Meunier N. , Pous R. , Sulis S. , Mary D. , Lagrange A.-M.
Published: June 2023

Context. Stellar variability impacts radial velocities (hereafter RVs) at various timescales and therefore the detectability of exoplanets and the mass determination based on this technique. Detecting and characterising Earth-like planets in the habitable zone of solar-type stars represents an important challenge in the coming years, however. It is therefore necessary to implement systematic studies of this issue, for example to delineate the current limitations of RV techniques.

Aims. A first aim of this paper is to investigate whether the targeted 10% mass uncertainty from RV follow-up of transits detected by PLATO can be reached. A second aim of this paper is to analyse and quantify Earth-like planet detectability for various spectral types.

Methods. For this purpose, we implemented blind tests based on a large data set (more than 20 000) of realistic synthetic time series reproducing different phenomena leading to stellar variability such as magnetic activity patterns similar to the solar configuration as well as flows (oscillations, granulation, and supergranulation), covering F6-K4 stars and a wide range of activity levels.

Results. We find that the 10% mass uncertainty for a 1 MEarth in the habitable zone of a G2 star cannot be reached, even with an improved version of the usual correction of stellar activity (here based on a non-linear relation with log R′HK and cycle phase instead of a linear correlation) and even for long-duration (10 yr) well-sampled observations. This level can be reached, however, for masses above 3 MEarth or for K4 stars alone. We quantify the maximum dispersion of the RV residuals needed to reach this 10% level, assuming the activity correction method and models do not affect the planetary signal. Several other methods, also based on a correction using log R′HK in various ways (including several denoising techniques and Gaussian processes) or photometry, were tested and do not allow a significantly improvement of this limited performance. Similarly, such low-mass planets in the habitable zone cannot be detected with a similar correction: blind tests lead to very low detection rates for 1 MEarth and to a very high level of false positives. We also studied the residuals after correction of the stellar signal, and found significant power in the periodogram at short and long timescales, corresponding to masses higher than 1 MEarth in this period range.

Conclusions. We conclude that very significant and new improvements with respect to methods based on activity indicators to correct for stellar activity must be devised at all timescales to reach the objective of 10% uncertainty on the mass or to detect such planets in RV. Methods based on the correlation with activity indicators are unlikely to be sufficient.
The LOFAR view of massive early-type galaxies: Transition from radio AGN to host emission
Authors: Capetti A. , Brienza M.
Published: June 2023

We extend the study of the radio emission in early-type galaxies (ETGs) in the nearby Universe (recession velocity < 7500 km s−1) as seen by the 150 MHz Low-Frequency ARray (LOFAR) observations and extend the sample from giant ETGs to massive (∼6 × 1010 − 3 × 1011 M⊙) ETGs (mETGS) with −25 < MK < −23.5. Images from the second data release of the LOFAR Two-metre Sky Survey were available for 432 mETGs, 48% of which are detected above a typical luminosity of ∼3 × 1020 W Hz−1. Most (85%) of the detected sources are compact, with sizes ≲4 kpc. The radio emission of 31 mETGs is extended on scales ranging from 2 to 180 kpc (median 12 kpc). In several cases, it is aligned with the host galaxy. We set a limit of ≲1% to the fraction of remnant or restarted objects, which is ≲16% of the extended sources. We found that the properties of the radio sources are connected with the stellar mass of the ETGs (the median radio power, the fraction of extended radio sources, and the link with the large-scale environment). However, these results only describe statistical trends because the radio properties of sources of similar stellar mass and environment show a large spread of radio properties. These trends break at the lowest host luminosities (MK > −24.5). This effect is strengthened by the analysis of even less massive ETGs, with −23.5 < MK < −21.5. This suggests that at a mass of ∼2 × 1011 M⊙, a general transition occurs from radio emission produced from radio-loud active galactic nuclei (AGN) to processes related to the host galaxy and (or) radio quiet AGN. At this luminosity, a transition in the stellar surface brightness profile also occurs from Sérsic galaxies to those with a depleted stellar core, the so-called core galaxies. This finding is in line with previous results that indicated that only core galaxies host radio-loud AGN.
Safety flight envelope calculation and protection control of UAV based on disturbance observer
Authors: Ma Biao , Chen Mou
Published: June 2023

In this paper, as for the unmanned air vehicle (UAV) under external disturbance, an attainable-equilibrium-set-based safety fight envelope (SFE) calculation method is proposed, based on which a prescribed performance protection control scheme is presented. Firstly, the existing definition of the SFE based on attainable equilibrium set (AES) is extended to make it consistent and suitable for the UAV system under disturbance. Secondly, a higher-order disturbance observer (HODO) is developed to estimate the disturbances and the disturbance estimation is applied in the computation of the SFE. Thirdly, by using the calculated SFE, a desired safety trajectory based on the time-varying safety margin function and first-order filter is developed to prevent the states of the UAV system from exceeding the SFE. Moreover, an SFE protection controller is proposed by combining the desired safety trajectory, backstepping method, HODO design, and prescribed performance (PP) control technique. In particular, the closed-loop system is established on the basis of disturbance estimation error, filter error, and tracking error. Finally, the stability of the closed-loop system is verified by the Lyapunov stability theory, and the simulations are presented to illustrate the effectiveness of the proposed control scheme.
Family influences on adolescent loneliness
Authors: Ying Mingjun
Published: June 2023

Loneliness is one of the negative emotions that is often brought up in everyday life. Loneliness has a variety of negative effects and can lead to suicidal thoughts at best. Loneliness can be felt at different levels at different ages, and adolescents are the most likely to experience it. Therefore, interventions for adolescent loneliness are necessary. Among the many factors that influence adolescent loneliness, the family, as the environment that adolescents are most familiar with and most often exposed to, has a different impact on adolescent loneliness in different dimensions. There are many studies that directly explore family and adolescent loneliness, but the categories are rather heterogeneous. Therefore, this paper collates and summarises three main aspects, namely family function, parenting style, and parent-child relationship, and analyses the effects of these three aspects on adolescent loneliness, finding that they all negatively predict adolescent loneliness. Meanwhile, factors such as personality, peer attachment, and self-esteem play different roles. Therefore, the study suggests that parents should spend more time with their children and adopt positive parenting styles to reduce adolescent loneliness.
Exploring the Nature and Impact of School Bullying: The effects of individual and environmental factors
Authors: Wang Qi
Published: June 2023

School bullying is a severe issue that accounts for a considerable proportion of juvenile delinquency. The increasing amount of research from different countries and ages related to school bullying shows various findings that confuse the public. As a result, this paper aims to review the leading causes and impacts of general school bullying that covers elementary children to high school students and school response to students’ bullying behavior. Regarding the bully, their behavior is associated with gender, grades, relationships, family, and other factors. Not only individual and environmental risk factors triggering the bullying are interpreted, but also the mental health problems and academic achievement influence of victims who suffered from bullying are revealed in the result.
The Role of Comprehensive Sex Education on the Prevention of Sexual Assault Against Minors and Its Suggestions
Authors: Zhang Yangfan , Yu Na
Published: June 2023

At present, the current situation of the phenomenon of sexual assault against minors in China presents the characteristics of large number and obvious characteristics of low age, acquaintances commit serious crimes, strong concealment, many times and long duration, and rising proportion of male victims. However, the current sex education in China belongs to chastity education, which cannot effectively play a preventive role. It is urgent to promote comprehensive sex education in terms of establishing advanced education concept and healthy sexual values, changing sex education mode, implementing age-specific education and strengthening supervision, so as to prevent sexual abuse of minors.
The impact of COVID-19 on student health behavior in k-12 public schools in Alabama
Authors: Chen Henry
Published: June 2023

COVID-19 has had a significant impact on the health behavior of students all over the world. This study aims to explain the critical role of COVID-19 in changing students’ health behaviors and to provide suggestions for improving students’ health by preventing the usage of harmful substances. This study uses data from the Alabama Department of Education, focusing on subject and enrollment data. Excel and SPSS are used to analyze the trend of the total number of students in each state with time, and the mean values of school data before and during COVID-19 are compared. People may expect that the pressure from the lockdown and studying online causes severe abuse of alcohol, drugs, and tobacco. However, this study finds an opposite conclusion that COVID-19 actually discouraged the use of those substances. The study shows that the total usage of alcohol, drugs, and tobacco illustrates a downward trend due to the blockade of COVID-19. However, after COVID-19 stabilized, the total amount of the three substances suddenly increased. In 2021-2022, there is a significant difference in the total amount used between k-6 and 7-9. These could be mainly explained by peer effect and parent controls which had less impact during covid-19 and became a dominant health effect factor after COVID-19. Finally, we give some suggestions for schools and parents to prevent the problem from worsening.
Using Cognitive Therapy to Explore the Potential Application of Traditional Therapy and Metaverse Therapy from a Cognitive Perspective
Authors: Yang Chuanhua
Published: June 2023

Depression, as a common mental disorder, results in a large number of individuals developing depression from depressive tendencies every year. However, due to the significant gap in mental health service access and geographical limitations, individuals experiencing symptoms of depression are unable to receive timely treatment. With the development of metaverse technology, it is now possible to use metaverse technology for widespread depression treatment. This article proposes some potential ideas for treating depressive tendencies and depression using a combination of traditional cognitive therapy methods and metaverse approaches. This aims to provide ideas for the future development of metaverse diagnostic and therapeutic technologies and to promote the reduction of the number of individuals who develop depression from depressive tendencies.
Can sustained development of education lead to employment - an empirical study based on TVP-VAR model
Authors: Xia Yuling , Luo Yuexin , Zhou Anan , Jiang Sheng
Published: June 2023

This paper explores the time-varying nature of the continuous development of education and employment from 1993-2021, completes the measurement of education integrated scale and education integrated talent indicators using the entropy power method, constructs a TVP-VAR model, and completes the investigation of the dynamic relationship between changes in education development and changes in employment growth using equally spaced impulse responses and time-point impulse responses. It is found that: there are different degrees of positive and negative impact fluctuations of the change in increase in education expenditure, the change in increase in education integrated scale and the change in increase in the number of education integrated talents on the change in employment growth, and overall the change in increase in education expenditure, the change in increase in education integrated scale and the change in the number of education integrated talents positively affect the change in employment growth under medium-term shocks. Based on the results of the study, this paper puts forward relevant suggestions for further promoting the positive impact of continuous development of education on employment growth.
The construction and practice of Curriculum Ideological and political education of apparel majors in applied undergraduate universities
Authors: Yin Xue-Feng , Fu Ju-Fen
Published: June 2023

Since the 18th Party Congress, the status and role of curriculum ideological and political education in the ideological and political work of universities have been further clarified and strengthened. Based on the positioning of talent cultivation and the attributes of the apparel major in Applied Technology College of Soochow University, this paper refines Chinese excellent traditional costume culture and skill transmission as the core ideological and political education concept for the major construction. In turn, this paper refines the corresponding elements of ideological and political education. It further proposes the implementation path of talent cultivation of this major under the ideological and political education concept, as well as the construction process of the specific course ideological and political education demonstration course The construction points and the mapping relationship between each link and the elements of ideological and political education in the construction process of specific courses of ideological and political education have achieved remarkable results and demonstration effects. The resulting construction program of curriculum ideological and political education under the dual drive of professional and ideological and political education provides ideas for other majors to draw on for the construction of curriculum ideological and political education.
Language, the Signifier, and the “Point de Caption”: From Saussure to Lacan and Žižek
Authors: Yang Shujun
Published: June 2023

The paper aims to return to the structural linguistics of Ferdinand de Saussure to examine the application of the structural linguistic terminologies in Lacanian psychoanalysis and the critique of ideology by Slavoj Žižek. First, the author examines Saussure’s structural linguistics terminologies in his book Course in General Linguistics. Then, the differences between its original definitions and their application in Lacanian psychoanalysis and the critique of the ideology of Slavoj Žižek are compared. The author found that although the French psychoanalyst Jacques Lacan used various linguistic terminologies that are initially from Saussure’s structural linguistics, he radically rewrote those concepts and perfectly “quilt” them into his theory of psychoanalysis. Besides, Slovenian philosopher Slavoj Žižek carefully examined the Lacanian linguistic view and applied it to the critique of ideology. Indeed, many correlations between Lacanian linguistic terminologies and Saussure’s terminologies in his structural linguistics have been fully concerned by scholars around the world. Nevertheless, from the author’s point of view, it is essential for people nowadays who would like to examine contemporary philosophy deeply, psychoanalysis as well as the critique of ideology to return to Saussure’s book and carefully examine the original forms of the linguistic terms. Thus, this paper mainly focuses on the idea of Sassure’s structural linguistics to give readers some new inspiration by tracing the origin of structural linguistic terms.
A study on the factors influencing undergraduate students’ sense of learning gain based on learning experience
Authors: Jiang Tianying , Guo Qian , Xiao Zezhong , Zhang Bo , Liang Yiwen
Published: June 2023

Undergraduate students, as the core group in higher education teaching activities, the sense of learning gain is an important manifestation of the education work in universities. Based on this, a questionnaire survey was conducted on the learning experience of undergraduate students in a certain university in Beijing from six dimensions: learning engagement, classroom experience, learning methods, teacher influence on students’ learning, school support for students’ learning, and sense of learning gain. And based on survey data, we will focus on exploring the influencing factors that affect students’ sense of learning gain, in order to provide reference for universities to identify the path to improve students’ sense of learning gain, and to achieve high-quality development of higher education.
Analysis of the Hotspots and Trends of New-media Ideological and Political Research: Citespace Visual Analysis Based on the Literature from 2012 to 2021
Authors: Dongjie Wu , Yonggang Zhang , Sisi Huang
Published: June 2023

Nowadays, the rapid development of Internet technology and the wide application of new media technology have brought unprecedented challenges and opportunities to the ideological and political work in colleges and universities. Against this background, promoting the high integration of traditional advantages of ideological and political work with information technology is conducive to enhancing ideological and political education’s keeping pace with the times and its appeal. To this end, based on the analysis of Citespace visual data of related literature from 2012 to 2021, this research investigates the frontier hotspots and theoretical focus of new media ideological and political research in China. As a whole, the discussion on the research trend of ideological and political work based on the new-media environment reveals that future related research will focus on the new-media turn of traditional ideological and political work, encompassing the transformation of concepts, the innovation of paths, as well as the cultivation of talent teams.
On the Legal Protection of Campus Online Loans and Its Regulation
Authors: Xu Bing
Published: June 2023

With the continuous development of campus online loans, many problems have emerged while bringing convenience to college students. Some campus online lending institutions have false propaganda and unfair competition, charging high and unreasonable fees when students take out loans, tempting students to “use loans to support loans”, buying and selling students’ personal privacy information, and using violent collection methods when students cannot repay the loans in time. In the face of these problems, the government should improve the supervision system of campus online lenders, establish a database to provide personal credit assessment, and schools should enhance the management of campus online lending, regularly carry out mapping work, and enhance the legal awareness of college students, while promoting the participation of governmental supervision departments, schools, and society, so that campus online lending can develop in a benign way and provide more convenience forcollege students.
Push-Pull Factors Influencing Chinese Mainland Students Attending IBCs: A Case Study
Authors: Chen Lu
Published: June 2023

This qualitative study, applying in-depth interview and push-pull theory, analyzed the factors influencing Chinese students’ choices to attend international branch campuses (IBCs) in China. The results showed that the pull factors can be found from admission policies, pedagogical characteristics, and postgraduation issues, while the push factors are caused by China’s higher education entrance examination. This study also discussed the reverse-push and reverse-pull factors, finding that the overseas universities tend to have a pull force that attracting Chinese students to leave IBCs, and factors like social recognition and course arrangement may discourage Chinese students to attend IBCs.
Anhedonia symptom of depressive disorder in adolescents
Authors: Li Sarah
Published: June 2023

Major Depressive Disorder is a mental disorder that’s common among adolescents, while anhedonia, characterized by the diminish in ability to enjoy pleasurable activities and loss of interest. The essay is written to examine factors that can contribute to onset of adolescent anhedonia in the context of MDD and its impacts on adolescents. The author read and analyze scientific studies pulished in National Library of Medicine, then combine her personal observation and experience with knowledge she had gained online. Past studies concluded that adolescent anhedonia is a result of a combination of varying factors such as reduced activities in the reward system, emotional neglect in childhood, social pressure. Adolescents who have anhedonia tend to be less motivated and have less expectation of future events, which will hinder their performance in school or outside of school. Despite of past studies that are conducted to help finding a cure for adolescent anhedonia, more research is needed to be conducted concentrating on adolescent with anehdonia as an individual.
Research and analysis of the current situation of the learning needs of Chinese middle-aged and elderly users
Authors: Wang Yan , Ma QianHui , Wang Jinghao , Li Qiuyuan , Du Mingxuan
Published: June 2023

As the issue of aging society gradually emerges, it has attracted widespread attention from society. Among them, the issue of the demand of some elderly groups for online course learning has also caught the attention of the authors. The aim of this thesis research is therefore to help the elderly adapt to an intelligent society as an entry point, to enable them to embrace the beauty of the Internet and to promote the achievement of active aging as the ultimate goal. This paper uses questionnaires and interviews to research older people aged 55-60 through online and offline research. It also provides research data to discover the current problems of elderly users and proposes solutions. It provides new directions for companies to develop business models for the elderly.It also enriches the theoretical connotation of the concept of senior communication and allows for further cross-disciplinary field integration between aging communication and business strategy.
Research and Exploration on the Reform of Engineering Training Mode
Authors: Xue Kaifeng , Xing Mingming , Yin Yuliang
Published: June 2023

This paper discusses the reform of engineering training mode to improve teaching quality and effectiveness. The current problems, such as the disconnection between theory and practice and insufficient student ability training, are analyzed. The proposed reform measures include enhancing practical teaching, innovating course settings, establishing engineering laboratories and practice bases, and strengthening student ability training. This paper emphasizes the importance of the reform of engineering training mode as a trend and future direction of higher education. Only through continuous reform and innovation can we better adapt to social changes and make greater contributions to cultivating high-quality engineering talents. Schools, teachers, and students should work together to optimize course settings, focus on practical teaching, and improve the practical effectiveness of courses. In conclusion, this paper provides a comprehensive analysis of the reform of engineering training mode, highlighting the importance of practical teaching and student ability training. Practical and effective reform measures and methods are proposed, providing useful insights for the cultivation of high-quality engineering talents.
Research on the Co-evolution of Professional Managers and Enterprises under the Background of Transnational Technology Transfer in Service Industry
Authors: Chen Ying , Sun Wenxia
Published: June 2023

Transnational technology transfer of service industry has become a new trend of international economic development. By using second-hand data, the professional managers of ten service multinational companies from different countries in China are selected as the research objects for empirical research. Taking pthe degree of localization of middle-and high-level professional managers in the multinational companies as dependent variables, and the year when multinational companies entered China, the type of industries, the scale of enterprises and the geographical distance from China as independent variables, this paper deduces by SPSS.18, and makes an empirical study on this basis. The conclusion of this paper is that cultural differences are the most important factors that determine the localization of professional managers serving multinational companies. Geographically close to China, the cultural gap will be smaller than that of countries far from China, and the degree of localization and operation of multinational enterprises will be higher, otherwise, the degree of localization will be lower.
Prevalence of Thyroid Peroxidase and Thyroglobulin Autoantibodies in
the Swedish Population
Authors: Bergemann Neele , Jonsdottir Berglind , Nilsson Anna-Lena , Lantz Mikael , Lind Alexander
Published: June 2023

Autoimmune thyroid disease (AITD) may be detected prior to clinical symptoms
through the presence of autoantibodies against thyroid peroxidase (TPOab),
thyroglobulin (TGab), or both.

The present study aimed to develop a novel radiobinding assay (RBA) for TPOab and
to determine the prevalence of TPOab and TGab in the Swedish population.

Patient samples from 27 newly diagnosed Graves’ disease patients in
longitudinal follow-up and 124 AITD autoantibody-positive children in
prospective follow-up for increased risk of type 1 diabetes were included to
validate the novel RBA for TPO. The results of RBA were compared with those
obtained by commercial radioimmunoassay (RIA) and electrochemiluminescence
(ECL). Furthermore, 476 serum samples from adult blood donors and 297 from
13-year-old school children were analyzed for the presence of TPOab and
TGab.

Receiver operating characteristics analysis for the novel TPOab resulted in an
area under curve (AUC) value of 0.82 (p<0.0001), a sensitivity of
77.8%, and a specificity of 91.9% in adult blood donors, and an
AUC value of 0.70 (p<0.0001), a sensitivity of 53.2% and a
specificity of 95.3% in the 13-year-old school children, respectively.
TPOab levels in RBA correlated with both ECL (r=0.8950,
p<0.0001) and RIA (r=0.9295, p<0.0001). The prevalence
of TPOab and TGab was 6.3% and 7.6% in adult blood donors and
2.9 and 3.7% in 13-year-old school children.

In conclusion, a novel RBA for the determination of TPOab was developed and
validated with current methodologies. This study also reports an increasing
prevalence of thyroid autoantibodies from adolescence to adulthood.
Spinal Surgery in Patients with Type-1 Neurofibromatosis: A Comprehensive Review
Authors: Joaquim Andrei Fernandes
Published: June 2023

Type-1 neurofibromatosis (NF1) is a neurocutaneous syndrome classically known as peripheral NF to distinguish it from type-2 NF (central NF). Its main characteristic is the high predisposition to the growth of multiple tumors, which specially arouses the interest of spinal surgeons due to the presence of spinal cord compression and spinal deformities.

Considering this, we have performed a comprehensive review, with illustrative cases of the main manifestations of NF1, focusing on the perspective of the spine surgeon. Articles were grouped according to the following subjects: diagnosis, skeletal complications, spinal deformity, and spinal tumors. For all of them, a detailed discussion on pearls for practice was presented.

The diagnosis of NF1 is based on the presence of at least two out of seven criteria. Cutaneous findings are very common in NF1, and the most usual tumor is cutaneous neurofibroma (NFB). Plexiform neurofibromas are also found and present a high risk of becoming malignant peripheral nerve sheath tumors (MPNSTs), reducing life expectancy. Astrocytomas, especially pilocytic astrocytomas, are the most common central nervous system tumor, including in the spinal cord. Surgery is necessary to resect as much as possible without adding new neurological deficits. Spinal deformities are also commonly found (in 30–70% of the cases), potentially associated with dystrophic changes, which may result in acute and rapid progression.

In the present review, we discuss specific characteristics found in this group of patients which are of paramount importance to properly manage this challenging disease.