bluuebunny/crossref_metadata_2025 huggingface dataset:
USING FLIPGRID AS ELECTRONIC PORTFOLIO IN SPEAKING ASSESSMENT
Authors: Subiana Ismiati Purwaningsih , Sukyadi Didi , Purnawarman Pupung
Published: July 2022

 

Given the prolonged pandemic situation that forced schools to run online in both synchronous and asynchronous modes has impacted some changes in either teaching practice or conducting the assessment. With the limited timetable provided to each school subject, there is a significant adjustment that the teachers should take to make the teaching and learning meaningful, not to mention in assessing students’ learning. In the English as a Foreign Language (EFL) setting, assessing speaking is another challenge the teachers encounter specifically during online teaching. Consequently, English teachers are required to have specific strategies to manage this assessment still. Electronic portfolio-based assessment has been shown to serve both as an effective learning tool and assessment tool. Hence, this study was aimed to investigate the use of the Flipgrid as the electronic portfolio in assessing speaking. The qualitative design was applied in this study with students' scores, teacher’s field notes, and questionnaires as the instruments to collect data. This study was expected to describe the washback of the Flipgrid as electronic portfolios in speaking assessment.

 

BAHASA INDONESIA ABSTRAK

Situasi pandemi yang berkelanjutan telah memaksa setiap sekolah untuk melaksanakan pembelajaran daring baik secara synchronous maupun asynchronous. Hal ini berdampak pada berubahnya praktik mengajar dan penilaian dalam pembelajaran. Dengan jadwal pembelajaran yang terbatas untuk setiap mata pelajaran, guru harus dapat melakukan penyesuaian yang signifikan untuk membuat proses kegiatan belajar mengajar menjadi berarti, begitu pula dengan penilaian hasil belajar siswa. Pada pembelajaran bahasa Inggris sebagai bahasa asing, penilaian keterampilan berbicara menjadi tantangan tersendiri bagi para guru khususnya pada saat pembelajaran daring. Sebagai konsekuensinya, setiap guru bahasa Inggris harus memiliki strategi tertentu untuk dapat mengelola penilaian dalam proses pembelajaran. Penilaian berbasis portofolio elektronik telah menunjukkan bahwa penilaian ini digunakan sebagai alat pembelajaran dan penilaian yang efektif. Oleh karena itu, penelitian ini bertujuan untuk menelaah penggunaan Flipgrid sebagai portofolio elektronik pada penilaian keterampilan berbicara dalam pembelajaran Bahasa Inggris. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan kualitatif dengan menggunakan nilai siswa, catatan lapangan guru, dan kuesioner sebagai instrumen untuk mengumpulkan data. Penelitian ini diharapkan dapat mendeskripsikan dampak penggunaan Flipgrid sebagai portofolio elektronik pada penilaian keterampilan berbicara dalam pembelajaran Bahasa Inggris.

 
Issues of COVID-19 morphological diagnosis in the practice of forensic medicine
Authors: Stepanov S. A. , Zhiganova M. S. , Pavlova O. N.
Published: July 2022

The study of the human corpses who died from the coronavirus infection COVID-19 allows to define the exact cause of death, which helps clinicians in choosing a timely and effective treatment to reduce mortality. The study analyzed the current literature with the results of studies of cadaveric material and described macro- and microscopic autopsy findings we observed. The description of autopsy cases of those who died from COVID-19 is certainly important for a comprehensive analysis of this problem and is of high clinical and epidemiological interest.
Recommendations for improving the regional regulatory framework in the implementation of multiorgan transplantation programs
Authors: Yaremin B. I. , Gubarev K. K. , Selutin A. A. , Bogdanov R. I.
Published: July 2022

These recommendations were approved at the meeting of the Samara regional branch of the Society of Transplantologists, protocol № 6, 2022. They contain recommendations for the actions of health authorities at the beginning of multiorgan transplantation programs.
Breastfeeding Self Effi cacy and Effective Breastfeeding on Postpartum Mother
Authors: Pradanie Retnayu
Published: July 2022

Introduction: Breastfeeding has been identifi ed as the optimal source of nutrition for infants. However, many mothers do not breastfeed their infants excusively. The possible modifi able factors to improve breastfeeding rates are breastfeeding self effi cacy and effective breastfeeding behavior. The aim of this study was to analyze the breastfeeding support package to improve breastfeeding self effi cacy and impact on effective breastfeeding behavior.Methods: This study was a quasy experiment pre-post test non equivalent control group design. Samples were 20 respondents recruited using consecutive sampling in Navy Hospital Dr. Ramelan who met the inclusion criteria. Instruments that used in this study were breastfeeding self effi cacy short form and LATCH assessment tool.Results: The score of breastfeeding self effi cacy on experiment group was improve higher than control group. But, the hypothesis test showed that there were no difference score between experiment and control group after intervention (p = 0.104). The correlation between breastfeeding self effi cacy and effective breastfeeding behavior was not signifi cant (p = 0.976). Conclusion: The antecedent of breastfeeding self effi cacy were not only the information resources but also job and education level. Breastfeeding self effi cacy was not an antecedent of effective breastfeeding behavior.
Response and Coping on Physically to Side Effect Cemotherapy in Women Suffered Cervical Cancer
Authors: Ambarwati Winarsih Nur , Wardani Erlinda Kusuma
Published: July 2022

Introduction: The Cervical cancer is a cancer that causes most deaths especially in developing countries. The management for most cancer is chemotherapy. Chemotherapy has many impacts in many areas of life, among others, the impact lays on the physical and psychological. Lack of information about the side effects of chemotherapy treatments cause the quality of life of patients continued to decline. The Objective of the research: It: is to develop the concept of responses and coping physically of the cervical cancer patients who received the chemotherapy. Methods: The study design was designed using qualitative methods. The approach used was qualitative research of the Phenomenology Study. The subjects of the research were the women with cervical cancer treated by chemotherapy in Hospital of Dr. Moewardi of Surakarta. The sampling technique was the purposive sampling. The research instruments were interview guidelines, observation guidelines, stationery and recording devices, and fi eld notes. The data analysis would be conducted by using qualitative analysis.Result: The physical response of cervical cancer patients on chemotherapy include nausea, vomiting, constipation, peripheral neuropathy, fatigue, weight loss, alopecia, skin toxicity, decreased appetite, pain, change in taste on the tongue. The coping of the patients generally use traditional ways or leave it, and very few pharmacological were used to resolve the problem.Conclusion: Chemotherapy give real effect to the physical. Patients in general were coping by traditional and non-pharmacological means. Suggestion: the results of the research can be used as evidence-based research in the treatment of cervical cancer patients with chemotherapy and used as the basis for the development of interventions to improve the life quality of the patients.
An Ergonomic Desk and Chair Prototype to Improve Seating Position on Senior High School Students at Kabupaten Gresik
Authors: Nilamsari Neffrety , Soebijanto Soebijanto , S.M. Lientje , B.R. Setokoesoemo
Published: July 2022

Introduction: The need of desks and chairs at school which appropriate with student’s anthropometry are very important. Desks and chairs which not suit with student’s anthropometry will lead to fatigue. At Kabupaten Gresik, the provision of desks and chairs which suit with student’s anthropometry still less in number. This study was aimed to provide recomendation for an ergonomic desk and chair prototype to improve seating position on senior high school students at Kabupaten Gresik.Methods: This was preexperiment research with one group pre post test design. Research subjects were students at SMAN 1 Menganti and SMAN 1 Cerme, Kabupaten Gresik, 139 students were involved.Results: The recomendation of ergonomic desks and chairs specifi cation according to student’s anthropometry were: 1) Prototypechair N, length = 48 cm, wide = 43 cm, cushion base’s height from floor surfaces = 47 cm, bag keeper’s height from floor surfaces =3cm, bag keeper’s wide= 43 cm, bag keeper’s length = 47 cm, cushion’s wide = 41 cm, cushion’s length = 46cm, handrest’s height = 22 cm, handrest’s length = 30 cm, backrest’s height = 38 cm, backrest’s wide = 43 cm, cushion’s foam thickness = 4 cm, backrest’s foam thickness = 4 cm; 2) Prototype desk N, length = 50 cm, wide = 66 cm, back section’s height = 85 cm, front section’s height = 75 cm, footrest from fl oor surfaces = 10 cm, drawer’s height = 10cm, front bamper’s height = 40 cm, and table’s angle = 10o.Conclusion: An ergonomic desks and chairs are very important for students at school, it will help teaching learning process run well and comfortable. The measurement of desk and chair must be reviewed after fi ve years, because of student’s anthropometric development. So then students will feel no fatigue.
Modification of Breast Pump as a Negative Pressure Wound Therapy for Accelerating Wound Healing of Diabetic Ulcer
Authors: Sari Yunita , Purnawan Iwan , Hartono Hartono
Published: July 2022

Introduction: Negative Pressure Wound Therapy (NPWT) is considered as the best treatment for accelerating wound healing, including diabetic ulcer. However, this device is still not available in Indonesia. Therefore, the purpose of this study were to make NPWT by using modifi cation of breast pump, and to elucidate the effect of this device on acceleration of wound healing in diabetic ulcer.Methods: NPWT was made by using digital breast pump. Wounds were divided into two groups; wound-treated by NPWT (experimental group) and wound-untreated by NPWT (control). The negative pressure used for this study was 85 mmHg. Rats were sacrifi ced on day 7, and wound samples and surrounding skin were stained with Hematoxylin and Eosyn. Infl ammation, intensity of necrotic tissue, and wound closure were observed.Results: The device could deliver a negative pressure at a range of 85–140 mmHg. Wound size in the experimental group was smaller than in control group. Infl ammation was also less in the experimental group than control group.Conclusion: The modifi cation of breast pump could be used as a negative pressure therapy for wounds, and has effect on reducing infl ammation and necrotic tissue. Further study is needed to elucidate the effect of this device on human subject.
Cognitive Support Increase CD4 Level on Patient with HIV at Kota Kediri
Authors: Peristiowati Yuly , Siyoto Sandu , Wardani Ratna
Published: July 2022

Introduction: HIV still becomes health problem that threaten Indonesia and many countries around the world. When HIV enters the body, it looks for CD4 cells and begins to replicate itself. Once replicated and left the dead CD4, the new viral particles will be looking for and infecting new CD4. The purpose of this study was to determine the effects of cognitive supports on CD4 level people living with HIV. Those cognitive supports consist of information, psychological, and spiritual support in order to increase the levels of CD4.Methods: This was quasy experiment research with posttest group design. Population were all people living with HIV at Kota Kediri. Samples were 20 respondents who meet the criteria, divided into two groups, intervention and control. The independent variable was cognitive support, while dependent variable was CD4 level of people living with HIV. Blood samples were collected to examine CD4 level. Data were then analyzed by using Anova test and T-test.Results: Results indicated that the cognitive supports had an effect in increasing the levels of absolute CD4 and CD4 percentage of people living with HIV at a signifi cance value of 0.003. However, there was no signifi cant difference between the control groups taking ARV regularly and irregularly.Conclusion: The provision of cognitive support was capable to stimulate the immune system by increasing T lymphocytes that have CD4 molecular markers. Thus, an increase in the levels of CD4 is expected to improve the quality of life of people living with HIV.
Hopelessness Experience among Stroke Survivor in Semarang
Authors: Sawab Sawab , Bahrudin Moch. , Catharina Daulima Novy Helena
Published: July 2022

Introduction: Hopelessness was a negative feelings about goal achievement and powerlessness feeling against an expectation. Hopelessness in stroke survivors can occur due to prolonged disability and neurologic defi cit. This condition can lead to emotional and mental disorders even a suicide action. Therefore, it was a need to explore hopelessness experience in stroke survivors.Methods: This study was a qualitative descriptive phenomenology with 6 participants.Results: 7 themes were revealed in this study, (1) Physical changes as a response on hopelessness, (2) Loss response as a hopelessness stressor, (3) Dysfunction of the family process, (4) Loss of meaning of life, (5) Self support and motivation as a coping resource against hopelessness, (6) The spiritual meaning behind hopelessness, (7) Can go through a better life.Conclusion: This study suggests to develop a nursing care standards in hopelessness, encourage a family support and family psychoeducation for stroke survivors.
The Effectiveness of Nursing Care: Social Isolation Implementation in Mental PMHNPM to Patient’s Capability
Authors: Syafrini Retty Octi Syafrini Octi , Keliat Budi Anna , Eka Putri Yossie Susanti
Published: July 2022

Introduction: Nursing care: social isolation is one of the pillars in Professional Mental Health Nursing Practice Model (PMHNPM). This study was aimed to determine the relationship between the implementation of nursing care in PMHNPM with the ability of clients and families client’s.Methods: This study was used a correlational design with cross-sectional approach. Samples were associate nurse who already follow PMHNPM training 58 respondents, client with social isolation problem who hospitalized at RSJD Prov. Jambi 32 respondents, and client’s family 12 respondents. Independent variable was PMHNPM implementation by associate nurse, while dependent variables were the result of nursing care to client with social isolation problem and family. Data were collected by using questionnaire. Data were then analyzed by using frequency distribution for categoric data, central tendency for numeric data, and pearson correlation.Results: The results showen that nursing management capabilities signifi cantly associated (p < 0.05) with the client’s ability and the ability of the family. The ability of nurses in providing nursing care social isolation were signifi cantly associated (p < 0.05) with a decrease in signs and symptoms of client upgrades.Conclusion: Associate nurses ability on nursing care and PMHNPM implementation could reduce a signs and symptoms, improve an ability of the client and families client’s social isolation.
A Nursing Management Model to Increase Medication Adherence and Nutritional Status of Patients with Pulmonary TB
Authors: Mar’ah Has Eka Mishbahatul
Published: July 2022

Introduction: High dropout rate, inadequate treatment, and resistance to medication, still become an obstacle in the treatment of pulmonary TB. Pulmonary TB patient care management at home can be done actively through telenursing. N-SMSI (Ners-Short Message Service Intervention) is one of community nursing intervention, in which community nurses send short messages to remind patients to take medication and nutrition. The aim of this study was to analyze the effect of nursing management model N-SMSI to increased medication adherence and nutritional status of patients with pulmonary TB.Methods: This study was used prospective design. The populations were new pulmonary TB patient at intensive phase, at Puskesmas Pegirian Surabaya. Samples were taken by purposive sampling technique; consist of 30 people, divided into treatment and control groups. The independent variable was N-SMSI. The dependent variables were medication adherence collected by using questionnaire and nutritional status by using measurement of body weight (kg). The data were then analyzed by using Wilcoxon Signed Rank Test, Mann Whitney, and Independent t-test with α ≤ 0.05.Results: The results of wilcoxon signed rank test had showed difference in the nutritional status of the treatment group before and after intervention, with p = 0.001. It’s similar with the control group, with p = 0.002. Mann whitney test results had showed no signifi cant difference in nutritional status between treatment and control group, as indicated by the value of p=0.589. While independent t-test had showed difference in compliance between treatment and control group, with p=0.031.Conslusion: N-SMSI can improve medication adherence of patient with Pulmonary TB. This model can be developed by nurse as alternative methods to improve medication adherence in patients with Pulmonary TB. Further research should modify nursing management model which can improve the nutritional status of patient with Pulmonary TB.
Individual Reminiscence Therapy can Decrease Depression Level on Elderly at Social Homes
Authors: Hidayati Laily Nur , Mustikasari Mustikasari , Eka Putri Yossie Susanti
Published: July 2022

Introduction: Aging is a natural process in oldest old. The psychosocial development of the elderly to enhance self-integration. Reminiscence therapy is one of psychosocial treatment for elderly using memory recall of one’s life event in the past. The purpose of this study was to determine the effect of individual reminiscence therapy on depression among elderly in the social homes.Method: The study design was used Quasy-Eksperiment Pre-Post Test with Control Group. A total of 60 elderly people were recruited in this study and assigned into two groups,  31 participants in the intervention group and 29 participants in the control group. Independent variable was reminiscence therapy five sessions, which given to the intervention group. While, dependent variable was the level of depression on elderly. Data were collected by using GDS, then analyzed by using Wilcoxon and Mann-Whitney statistical test with level of significance α≤0.05.Result: After providing individual reminiscence therapy, the intervention group showed a significant decrease in depression as compared to those in the control group was found (p=0.008).Discussion: The individual reminiscence therapy is useful to overcome depression among elderly. The nurse can know the personality of each elderly so as to improve the quality of nursing care for elderly.
Sap Extract Papaya for Autolitic Debridement Chronic Wound
Authors: Agus Yuswanto Tri Johan , Hariyanto Tanto
Published: July 2022

Introduction: The high cost of drugs or specific wound dressings for chronic wounds can be healed at least in two weeks depending on the stage of the wound and blood sugar levels. Hence the need for an innovative processing of natural resources (NR) to produce a chronic wound care products that are accessible to all people.  One of the current trends is to use protease enzymes (sap extract papaya) that serves as autolitic debridement in the treatment of chronic wounds. The aims of this research was to indentify characteristics of protease enzyme present in sap of papaya.Method: This study was a descriptive exploratory that doing pure protease enzyme extract of papaya sap. Results: Molecular weight measurement using a kit Pre-stained Protein Markers (Broad Range) for SDS PAGE, Nacalai tesque No. 02525 showed a homogeneous molecular weight that slightly above 28 kD. Measurements of the enzyme levels using NanoDrop Spectrophotometer ND kit-1000 (with a distilled water marker) showed a relatively homogeneous enzyme level with a range between 43% - 61% and 53, 88% in average. The addition of papaya sap extract into each tube containing 7 ml gelatin obtained.Results: the control group there were clots perfectly on gelatin; groups with the addition of 2 drops (± 0.5 ml) obtained 50% hydrolyzed gelatin; and groups with the addition of 4 drops (± 0.5 ml) obtained 75% hydrolyzed gelatin.Discussion: The results showed that papaya sap extraction synonymous with protease enzyme. Papaya sap extraction activity (protease enzymes) on hydrolyzing gelatin shows a qualitative picture. Therefore, it can be used as autholitic debridement. Further, the following study is essential to identify structure and activity of the enzyme with a more determinant (temperature, time, and dose).
The Incident of Diarrhea among Cervical Cancer Patients Post Chemoterapy Treatment
Authors: Armini Ni ketut alit , Muhayanah Masfin , Nastiti Aria
Published: July 2022

Backgrounds :  Cervical cancer is second most diseases suffered by women. Chemotherapy is primary treatment for cervical cancer. Chemotherpy has some side effect, and one of them is diarrhea. Diarrhea make cervical cancer suffered more. The purpose of this research was to analyze the correlation of factor’s that cause diarrhea on  cervical cancer.Methods : This research uses descriptive analitic method with retrospective design. The population in this research is all patients who had post first chemotherapy. Sample in this study were 21 respondents, with purposive sampling. Variable independent were type of chemotherapy drugs, character of chemotheraphy, staging, stress and dietary. Variable dependent was diarrhea. Data collected using quesionare. Data were analyzed using chi square test with level of significant α≤0,05.Results : The result of the study reveals that type of the chemotherapy drug p:0,598, character of chemotheraphy p:0,336,. Staging  has correlation with diarrhea significant of p:0,022. Stress and dietary analysisis presented p:0,00. It means that there was significant correlation with diarrhea.Conclusion : It can be concluded that diarrhea  incident  related to staging, stress and dietarry. There‘s no correlation between type of chemotherapy drug, character of chemotheraphy with diarrhea Further studies should give health education about dietary causing diarrhea, chemotherapy procedural and sides effect’s, increase supports for patient with cervical cancer.
Deteksi Dini Derajat Kesadaran Menggunakan Pengukuran Nilai Kritis Mean Artery Pressure
Authors: Martono Martono , Sudiro Sudiro , Satino Satino
Published: July 2022

Introduction: The Impact of the trauma cranio cerebral can affect the volume autoregulation disorders any intracranial disease that consists of the brain and cerebrospinal fluid and the blood in the veins. The changes one of the volume without followed the response of compensation from the other factors will cause overt increased intracranial pressure changes and the amount of blood flow from the systemic circulation required to give oxygen and glucose intake to the metabolism of the brain. One of the things that is very important in nursing nursery on patients with injury head is to maintain the adequacy of Mean Artery Pressure cerebral. This research aims to know the adequacy of critical value mean artery pressure in detecting the level of consciousness in patients who suffered injury on the head.Methods: This research using explanatory design research with cross sectional approach that explains the influence and the prediction of the adequacy of the critical value mean arteria pressure against the degree of awareness in patients with injury head which numbered 34 samples. This research statistics tests using simple regression.Results: The results of the study showed that there is a positive influence critical value mean artery pressure against the degree of awareness that indicated the value of p=0.00<0.05 and value of mean artery pressure is able to detect the level of consciousness patients injury head of 77.8%.Discussion: Increased critical value mean arterial pressure is more than 65 mmHg can improve mikrosirkulasi and autoreglasi brain, so that prevent the decline of awareness in patients with wounds of the head.
Implementasi Sistem Manajemen Mutu Pelayanan Keperawatan Melalui Kepemimpinan Mutu Kepala Ruangan
Authors: Hidayat Aziz Alimul , Pratiwi Ana , Agustin Ratna
Published: July 2022

Introduction: The quality management system is an order that ensures the achievement of goals and quality objectives which are planned in nursing care. One of the factors that may affect the implementation of quality management systems in the inpatient units is the quality leadership of head nurse. This study aims to determine the effect of the quality leadership of the head nurse to the implementation of quality management systems of nursing cares in hospital.Methods: The research method uses analytical research with cross-sectional approach. The sample of this study consists of eight wards; They are Multazam pavillion, Arofah, Sakinah, Shofa Marwah, Annisa, Mina, Ismail, and ICU which meet with the inclusion and exclusion criteria. The data was taken by using simple random sampling. The data collection by using questionnaires, interviews and observation. Data analysis used a simple statistical linear regression tests with a significance the value of α ≤ 0.05.Results: The results showed that the quality of leadership of the head of wards is mostly good (50%) and the implementation of quality management system of nursing care is mostly good (62.5%). Results of analysis of the simple linear regression test on the influence of leadership quality of the head nurse through the implementation of the quality management system of inpatient units (ρ = 0.024).Conclusion: The results of this study expect the nurses to increase the commitment and responsibility in implementing the quality management system of nursing cares in the inpatient units so as to achieve the excellent quality of nursing cares and can boost confidence, satisfaction of patients, families, and communities on nursing care.
Model Pembelajaran Reproduksi Sehat Melalui Kelompok Sebaya pada Remaja Putri
Authors: Azza Awatiful , Susilo Cipto
Published: July 2022

Introduction: Teen problems are conditions that need to be considered in national development in Indonesia. Teenagers problems occur, because they are not prepared regarding knowledge of aspects related to the problem of transition from childhood to adulthood. One of the problems faced by teenagers today is about the health of adolescents, especially related to reproductive health.Methods: This study uses a quantitative approach pre experiment with pre - post test design, the purpose of research, construction of models of healthy reproductive learning through peer groups in traditional schools and analyze the application of learning through peer group against knowledge female students  about reproductive health. The sample was female students in Boarding school Miftahul Hasan Gunung Sepikul amounted to 50 female students, with purposive sampling technique.Results of analysis using Spearman's rho test ,P value of 0.00 obtained value where the value is < less than 0.05 so it can be concluded that there is a learning effect of reproductive health through peer groups for knowledge  female students .Conclusion: Boarding schools need to provide curriculum on reproductive health in order to improve the understanding of female students in healthy living behavior associated with reproductive organs.
Ekspresi HSP 70 dan Ekspresi Reseptor Opioid Mu pada Penurunan Nyeri Terapi Bekam Basah
Authors: Subadi Imam , Laswati Hening , JM Harjanto
Published: July 2022

Introduction: Wet cupping therapy widely used to reduce the pain, but the mechanisms of pain reduction on wet cuppig therapy is unclear. Stretching and punctures on wet cupping therapy cause stress on the cell. Cells that are stressed express HSP 70 and mu opioid receptors. This study aims to prove the correlation increased expression of HSP 70 and an increase in post-mu opioid receptor wet cupping therapy.Methods: The study is an experimental research design with randomized control group post-test only design. Twenty-four rats type Wistar (Rattus norvegicus) were randomly divided into three groups, each consisting of eight mice are negative control group (normal mice), group induction of pain with Complete Freund's Adjuvant (CFA) alone (positive control) and group by induction of pain and bekam basah therapy (10 puncture and negative pressure: - 200 mmHg, 5 minutes). Samples were taken from the skin and immunohistochemical examination with the monoclonal antibody anti mu opioid receptors. The reaction time pain threshold measured using a hot-plate. Data were analyzed by oneway ANOVA and Pearson Correlation using SPSS version 17.Results: This study shows that there is an increased expression of HSP 70 (P <0.05) compared to the positive control group (p <0.05) and increased expression of mu opioid receptors ( p <0.05) compared to the positive control group (p <0.05). There is an increased pain threshold reaction time (p <0.05) compared to the positive controls (11.78 ± 3.56). There is a correlation between an increased expression of HSP 70 and an increase in mu opioid receptor (β = 0893; p = 0.000) and there was a correlation between the increase in mu opioid receptor with a reaction time of pain threshold (β = 0713; p = 0.002).Discussion: Wet cupping therapy increase HSP 70 expression, opioid mu receptor, and decrease pain level.
Effect of Health Education on Mothers’ Knowledge in the Prevention of Acute Respiratory Infection in Toddlers in Waimital Village, Maluku
Authors: Tunny Ira Sandi , Soamole Idham , Wibowo Suhendra Agung , Purnamasari Ira , Rumaolat Wiwi
Published: July 2022

ABSTRACTIntroduction: Acute Respiratory Infection (ARI) is a disease caused by infectious agents that are usually toddlers, so it is expected that the family, especially the mother, plays a role in terms of having good knowledge about the prevention of ARI transmission.  Health education through visual aid leaflets is very effective to increase knowledge and understanding in preventing ARI disease.  The aim of this study was to determine the effect of health education on the level of maternal knowledge in the prevention of ARI in children under.Methods: The research design used was a pre-experiment with one group and a pretest-posttest design approach.  Intervention was carried out by way of house visits on a sample of 129 people. The research instrument used was questionnaire data analysis using the Wilcoxon test at a significance of (α <0.05).Results: Before doing health education, good knowledge was seen in 2 respondents or 1.6% and after the action of health education using leaflets, good knowledge was seen in 33 respondents or 25.6%. Statistical analysis of respondents' knowledge after treatment obtained an average value for knowledge of 68.84; the lowest value was 30 and the highest was 100, significant with a p-value = 0.000 (α <0.05).Conclusion: Health education using leaflets can increase mothers' knowledge so that it encourages self-efficacy and self-management and increases awareness in the prevention of disease.  There is an influence of health education on the level of maternal knowledge in the prevention of ARI among children under five.
Peer Group Support Decrease Depression Level In Menopause Woman
Authors: Yusuf Ah. , Armini Ni Ketut Alit , Hardiyan Deka
Published: July 2022

Introduction: Menopause woman has higher depression level than pre and postmenopause woman. Many woman who are getting menopause will feel lonely and don’t have any friends to talk, if this situation continue it can cause menopausal depression. Peer group support is one of group therapy which gives opportunity to menopause woman to get mutual support and help them to face the problem. This aimed of this study was to analyze the effect of peer group support in the menopause woman depression level.Methods: A quasy experimental pre-post test design was used in this study. There were 16 menopause women taken from Cepokomulyo Kepanjen. The independent variable was peer group support and the dependent variable was the depression level. Data were analyzed by Wilcoxon Signed Rank Test and Mann Whitney U Test with the significance level α<0.05.Results: Result showed that there was an effect of peer group support in the menopause woman depression level with significance level p=0.011 (treatment group) and p=0.23 (controlled group) and the result of Mann Whitney U Test showed that p=0.02.Conclusion: It can be concluded that peer group support can reduce the menopause woman depression level. It can be suggested to the institutional to practice peer group support to help menopause woman reduce their depression level.
The Role of The Koran Therapy on Anxiety and Immunity of Hospitalized Patients
Authors: Hammad Hammad
Published: July 2022

Introduction: Patient in the hospital faced with anxiety, in feel stronge with the hospital, medicine and treatment action although unsure prognosis of desease. The anxiety will inflict a financial loss because it will influence the attitude of the patient and immunology respons that will effect on how long the patient stay in the hospital and how much cost of treatment. This study was aimed to explain the anxiety level and imunity of patient in the hospital before and after The Al Qur’an therapy. Method: This study used Pre experiment pre-posttest design  involved 7 respondents, taken by accidental sampling.  The independent variable was The Al Qur’an therapy and the dependent variable were anxiety level and imunity (basofil, eosinofil, monocyt, limfocyt  and leucocyt). Anxiety level were collected by Hamilton Anxiey Rating Scale and the imunity were gotten from laboratory result of basofil, eosinofil, monocyt, limfocyt  and leucocyt . Data were analyzed using Wilcoxon Sign Rank Test for anxiety level and Mc Nemar for imunity with level of significance α ≤ 0.05.Result:  Results showed that The Al Qur’an therapy has an effect on decreasing anxiety level (p=0.016). In contrast, there was no effect on imunity after therapy (p = 0,625).  incision. It can be concluded that the Koran therapy was proven to reduce anxiety level and increased on imunity on patients hospitalized. Discussion: For future Further studies should be developed and include larger responden to obtain more accurate results.
The Predictors of Caregiver’s Burden and Depression Level in Caring Elderly People with Dementia at Community
Authors: Putri Yossie Susanti Eka , Riasmini Ni Made
Published: July 2022

Introduction: Most older people with dementia in Indonesia stay at home, cared by family members. Family caregivers even experience physical, psychological, social, and fi nancial problems. Care giving demands often lead to caregiver burden and depression. The objective of this study was to determine factors which contribute burden and depression experienced by the caregivers of older people with dementia.Method: Design was descriptive analytic with cross sectional approach. The population were caregivers living with older people with dementia. Sample size were 183 respondents. The independent variables were caregiver’s contextual factors, stressor caregiving, and intervening factor. The dependent variables were the burden of care and level of caregivers’ depression. Data were collected using questionnaire. Data were analyzed using linier regresion.Results: Statistical analyses showed marital status was significantly related to caregivers’ burden. While worked, education, and relationships with older people were significantly related with caregivers’ depression level. Memory and behavior problem, the task of caring and satisfaction of caring were related with caregivers’ burden and depression level. Multivariate analyses show health status was the most factors related to caregivers’ depression level. Memory and behavior problems was main factor related to caregivers’ burden of caring for older people with dementia.Conclusion: The results are expected to provide information about the extent of caregivers’ burden and depression which experienced in care giving, therefore the services can be designed based on the needs of the caregivers of persons with dementia in the community.
Solubility, acidifying power and sensory properties of fumaric acid in water, hydro-alcoholic solutions, musts and wines compared to tartaric, malic, lactic and citric acids
Authors: Gancel Anne-Laure , Payan Claire , Koltunova Tatiana , Jourdes Michael , Christmann Monika , Teissedre Pierre-Louis
Published: July 2022

The lower content of organic acids in grape berries due to global warming, and therefore high pHs, is forcing winegrowers to acidify must or wine to preserve their microbiological stability and their physico-chemical equilibrium. Acidification is essential to avoid damageable consequences on the colour and the sensory quality of the wines. Of the possible modes of acidification, chemical acidification is still the most common one used by OIV country members. It consists of adding lactic, malic, tartaric or citric acids to the musts and wines. Fumaric acid, with its high acidifying power and availability on the market, could be an interesting alternative at lower cost than other acids. Very few studies describing the effects of the addition of this acid on the chemical and organoleptic quality of musts and wines have been published. The present study therefore investigated the impacts of fumaric acid - namely its solubility, acidifying power, and impacts on colour and phenolic compounds - on musts and wines in comparison to other acids. Sensory analyses were also carried out to evaluate the perception threshold of each acid in the wines and compare how the acids are perceived. Except for its low solubility, fumaric acid seems to be a good candidate for an economic alternative to wine acidification. It had the highest acidifying power and slightly affected wine chemistry and organoleptic qualities. Further studies are needed to determine the appropriate step during which this acid should be added during winemaking.
Instantaneous Quantum Description of Photonic Wavefronts and Applications
Authors: Vatarescu Andre
Published: July 2022

Three physical elements are missing from the conventional formalism of quantum photonics: 1) the quantum Rayleigh spontaneous and stimulated emissions; 2) the unavoidable parametric amplification; and 3) the mixed time-frequency spectral structure of a photonic field which specifies its duration or spatial extent. As a single photon enters a dielectric medium, the quantum Rayleigh scattering prevents it from propagating in a straight-line, thereby destroying any possible entanglement. A pure dynamic and coherent state composed of two consecutive number states, delivers the correct expectation values for the number of photons carried by a photonic wave front, its complex optical field, and phase quadratures. The intrinsic longitudinal and lateral field profiles associated with a group of photons for any instantaneous number of photons are independent of the source. These photonic properties enable a step-by-step analysis of the correlation functions characterizing counting of coincident numbers of photons or intensities with unity visibility interference, spanning the classical and quantum optic regimes
A Simplistic and Cost-Effective Design for Real-World Development of an Ambient Assisted Living System for Fall Detection and Indoor Localization: Proof of Concept
Authors: Thakur Nirmalya , Han Chia Y.
Published: July 2022

Falls, highly common in the constantly increasing global aging population, can have a variety of negative effects on their health, well-being, and quality of life, including restricting their capabilities to conduct Activities of Daily Living (ADLs), which are crucial for one’s sustenance. Timely assistance during falls is highly necessary, which involves tracking the indoor location of the elderly during their diverse navigational patterns associated with ADLs to detect the precise location of a fall. With the decreasing caregiver population on a global scale, it is important that the future of intelligent living environments can detect falls during ADL.s while being able to track the indoor location of the elderly in the real world. Prior works in these fields have several limitations, such as – the lack of functionalities to detect both falls and indoor locations, high cost of implementation, complicated design, the requirement of multiple hardware components for deployment, and the necessity to develop new hardware for implementation, which make the wide-scale deployment of such technologies challenging. To address these challenges, this work proposes a cost-effective and simplistic design paradigm for an Ambient Assisted Living system that can capture multimodal components of user behaviors during ADLs that are necessary for performing fall detection and indoor localization in a simultaneous manner in the real world. Proof of concept results from real-world experiments are presented to uphold the effective working of the system. The findings from two comparison studies with prior works in this field are also presented to uphold the novelty of this work. The first comparison study shows how the proposed system outperforms prior works in the areas of indoor localization and fall detection in terms of the effectiveness of its software design and hardware design. The second comparison study shows that the cost for the development of this system is the least as compared to prior works in these fields, which involved real-world development of the underlining systems, thereby upholding its cost-effective nature.
Use of Deep Learning to Detect the Maternal Heart Rate and False Signals on Fetal Heart Rate Recordings
Authors: Boudet Samuel , Houzé de l'Aulnoit Agathe , Peyrodie Laurent , Demailly Romain , Houzé de l'Aulnoit Denis
Published: July 2022

We have developed deep learning models for automatic identification of the maternal heart rate (MHR) and, more generally, false signals (FSs) on fetal heart rate (FHR) recordings. The models can be used to preprocess FHR data prior to automated analysis or as a clinical alert system to assist the practitioner. Three models were developed and used to detect (i) FSs on the MHR channel (the FSMHR model), (ii) the MHR and FSs on the Doppler FHR sensor (the FSDop model), and (iii) FSs on the scalp ECG channel (the FSScalp model). The FSDop model was the most useful because FSs are far more frequent on the Doppler FHR channel. All three models were based on a multilayer, symmetric, GRU and were trained on data recorded during the first and second stages of delivery. The FSMHR and FSDop models were also trained on antepartum recordings. The training dataset contained 1030 expert-annotated periods (mean duration: 36 min) from 635 recordings. In an initial evaluation of routine clinical practice, 30 fully annotated recordings for each sensor type (mean duration: 5 h for MHR and Doppler sensors, and 3 h for the scalp ECG sensor) were analyzed. The sensitivity, positive predictive value (PPV) and accuracy were respectively 62.20%, 87.1% and 99.90% for the FSMHR model, 93.1%, 95.6% and 99.68% for the FSDop model, and 44.6%, 87.2% and 99.93% for the FSScalp model. We built a second test dataset with a more solid ground truth by selecting 45 periods (lasting 20 min, on average) on which the Doppler FHR and scalp ECG signals were recorded simultaneously. Using scalp ECG data, the experts estimated the true FHR value more reliably and thus annotated the Doppler FHR channel more precisely. The models achieved a sensitivity of 53.3%, a PPV of 62.4%, and an accuracy of 97.29%. In comparison, two experts (blinded to the scalp ECG data) respectively achieved a sensitivity of 15.7%, a PPV of 74.3%, and an accuracy of 96.91% and a sensitivity of 60.7%, a PPV of 83.5% and an accuracy of 98.24%. Hence, the models performed at expert level (better than one expert and worse than the other), although a well-trained expert with good knowledge of FSs could probably do better in some cases. The models and datasets have been included in the Fetal Heart Rate Morphological Analysis open-source MATLAB toolbox and can be used freely for research purposes.
Fine Epitope Mapping of the Vibrio cholera Toxins A, B, and P and an ELISA Assay
Authors: De-Simone Salvatore Giovanni , Napoleão-Pêgo Paloma , Gonçalves Priscilla Simone , Lechuga Guilher Curty , Cardozo Sergian Vianna , Provance David William , Morel Carlos Meicis , Silva Flavio Rocha
Published: July 2022

Oral immunization with the choleric toxin (CT) elicits a high level of protection against its enterotoxin activities and can control cholera in endemic settings. However, the complete B-cell epitope map of the CT responsible for protection remains to be clarified. Here, we have mapped the B-cell linear epitopes of the three chains of the CT protein (CTP) prepared by Spot synthesis. The immunoreactivity of sera from mice immunized with an oral, inactivated vaccine (Schankol†™) was measured against membrane-bound peptides for mapping. Results: Eighteen IgG epitopes were identified; eight in the CTA, three in the CTB, and seven in the protein P. Three epitopes, TQTGFVRHDDGYVST (aa 66-77, Vc/TxA-3), KNGAIFQVE VPGSQN (aa 64-78, Vc/TxB-11), and LNDEHK (aa 90-95, Vc/TxP-16), were chosen to synthesize a multiple antigen peptide that was used to coat ELISA plates to screen immunized mouse sera as a test for an in vitro diagnostics for cholera. Conclusion: Vaccination with inactive CT-generated antibodies against multiple linear epitopes and the selected epitopes can be used to construct immunological reagents for rapid serological diagnosis of cholera with high sensitivity and specificity.
Somatic Variation in Normal Tissues: Friend or Foe of Cancer Early Detection?
Authors: Acha-Sagredo Amelia , Ganguli Piyali , Ciccarelli Francesca D.
Published: July 2022

Seemingly normal tissues progressively become populated by mutant clones over time. Most of these clones bear mutations in well-known cancer genes but only rarely do they transform into cancer. This poses questions on what triggers cancer initiation and what implications somatic variation has for cancer early detection. We analysed recent mutational screens of healthy and cancer-free diseased tissues to compare somatic drivers and the causes of somatic variation across tissues. We then reviewed the mechanisms of clonal expansion and their relationships with age and diseases other than cancer. We finally discussed the relevance of somatic variation for cancer initiation and how it can help or hinder cancer detection and prevention. The extent of somatic variation is highly variable across tissues and depends on intrinsic features, such as tissue architecture and turnover, as well as the exposure to endogenous and exogenous insults. Most somatic mutations driving clone expansion are tissue-specific and inactivate tumour suppressor genes involved in chromatin modification and cell growth signalling. Some of these genes are more frequently mutated in normal tissues than cancer, indicating a context-dependent cancer promoting or protective role. Mutant clones can persist over a long time or disappear rapidly, suggesting that their fitness depends on the dynamic equilibrium with the environment. The disruption of this equilibrium is likely responsible for their transformation into malignant clones and knowing what triggers this process is key for cancer prevention and early detection. Somatic variation should be considered in liquid biopsy, where it may contribute cancer-independent mutations, and in the identification of cancer drivers, since not all mutated genes favouring clonal expansion also drive tumourigenesis. Somatic variation and the factors governing homeostasis of normal tissues should be taken into account when devising strategies for cancer prevention and early detection.