bluuebunny/crossref_metadata_2025 huggingface dataset:
Discursive construction of corporate identity through websites: An intercultural perspective on the commercial banks of the United States and China
Authors: Fu Heng , Zhu Huifen
Published: August 2022

With the assistance of the corpus analysis tool Wmatrix 4.0, this paper analyzes the semantic categories of the top 10 commercial banks of China and the United States to figure out their social-cultural behavior in the Internet business context. It is discovered that both common and distinctive identities were constructed: the common identities include the professional financial service provider, responsible corporation for employees, and relevant communities with environmental and social consciousness, while the distinctive identities are manifested in the communication strategy, style, and persuasion mode: (1) The Chinese Commercial Banks adopted the proactive strategy for corporate identity construction, are prone to take hierarchical and impersonal communication style, and more focused on the “credibility appeal” and “rational appeal” in persuasion mode; (2) the commercial banks of the United States are more reactive in the communication strategy, position themselves in short distance with the putative audience in communication style, and conform to the typical “affective appeal” regarding the persuasion mode. From the intercultural perspective, the distinctions are the representation of the peculiar high-context culture and low-context culture based on Hofstede's cultural dimensions theory. Chinese banks should try to shorten the cultural gap by adopting communication strategy in conformity with the local cultural when going global rather than sticking to the domestic communication strategy.
Relationship quality and exhibitors’ sustainable willingness to participate in exhibitions: A sociocultural perspective
Authors: Wang Pengfei , Liang Liuke , Pan Yu , Wang Yu , Li Linna , Chen Yanyan , Tian Yihan
Published: August 2022

Exhibition is a new economic business form in China. From a stakeholder perspective, all important roles in the context of hospitality and tourism are talents. From a socio-cultural perspective, interpersonal relationship quality plays a vital role in business and industrial operations. This constructs a causal model of relationship quality between exhibitors and exhibition organizers, and examined its influence on exhibitors’ willingness to sustainably participate in exhibitions. Data collected from a total of 251 exhibitors from 4 nation-representative exhibitions in Beijing were analyzed. The results found that the four antecedent variables—guanxi (as distinctive from relationship quality), service quality, communication, and exhibition effectiveness—have significant impacts on the relationship quality between exhibitors and exhibition organizers, which in turn, affect exhibitors’ willingness to participate in subsequent exhibitions (i.e., exhibitor loyalty). These findings provide a theoretical basis and policy recommendations talent management in exhibition context.
The road to green development: How can carbon emission trading pilot policy contribute to carbon peak attainment and neutrality? Evidence from China
Authors: Lan Junshi , Li Wenli , Zhu Xinwu
Published: August 2022

Carbon emission trading is not only a market-based instrument but also one of the government’s macro-policies, which is extremely crucial to fulfilling both carbon peak attainment and carbon neutrality goals. For this purpose, this paper adopts a 30-region dataset for the period from 2008 to 2020 in China and employs the difference-in-difference (DID) method to quantify the effect of the carbon emission trading pilot policy (CETP) on carbon emissions on the basis of introducing industrial structure upgrading and green technology innovation as moderating variables. The results show that (1) CETP has a statistically significant dampening effect on carbon emissions, while its carbon emission reduction effect follows a significant strengthening trend as the policy year of CETP implementation is delayed. (2) CETP has a significant carbon emission reduction effect. However, its effect demonstrates a gradual decrease from the eastern to the central and finally to the western regions. (3) CETP can inhibit carbon emissions depending on industrial structure upgrading to a certain extent, and this dependence is significant in the national and eastern regions but not in the central and western regions. (4) CETP’s carbon emission reduction effect is dependent on green technology innovation, which is only revealed in the western region and performs as a dampening effect in the national, eastern, and central regions, but not significantly.
Impact of psychological contract breach on firm’s innovative performance: A moderated mediation model
Authors: Zhang Lizhe
Published: August 2022

Organizations are seeking ways to be more competitive in the market. Globalization also paves the way for additional challenges for firms to compete in today’s knowledge-based economy and competitive corporate settings. The psychological contract breach (PCB) of employees could be a possible reason to slow down the firm’s innovative performance. Based on the social exchange theory, the present study assumes that a PCB negatively affects a firm’s innovative performance. The present study also assessed the mediating role of knowledge hiding (KH) and moral disengagement (MD) in the relationship between PCB and a firm’s innovative performance. This study also attempts to check the moderating role of perceived supervisor support (PSS) in the relationship between PCB and KH and between PCB and MD. For empirical investigation, the present study collected the data from 303 employees of various textile organizations in china through a structured questionnaire method using a convenient sampling technique. The present study applied partial least square structural equation modeling for empirical analyses using Smart PLS software. The present study revealed that a PCB does not directly influence a firm’s innovative performance. However, the results confirmed that KH negatively mediates the relationship between PCB and a firm’s innovative performance. On the other hand, results also confirmed that MD negatively mediates the relationship between PCB and a firm’s innovative performance. The finding also acknowledged that the PSS does not moderate the relationship between PCB and KH. Additionally, the findings confirmed that PSS positively moderates the relationship between PCB and moral disengagement. The present study offers important practical, theoretical, and managerial implications.
Prevalence and risk factors of depressive symptoms among 140,259 college students during the COVID-19 epidemic normalization in China: A cross-sectional survey
Authors: Luo Xiaoyu , Xu Qingqing , Fan Keliang , Wang Juan , Wei Dandan , Wang Xian , Lou Xiaomin , Lin Hualiang , Wang Chongjian , Wu Cuiping , Mao Zhenxing
Published: August 2022

Objective

College students are one of the most vulnerable populations to the COVID-19 pandemic's mental health effects. During the coronavirus disease 2019 (COVID-19) outbreak, we wanted to see how common depressive symptoms were among college students and what factors contributed to that.

Methods

Between 21 and 27 May 2021, 140,259 college students from three cities in Henan Province, China, were involved. The Patient Health Questionnaire-9 was used to determine depressive symptoms (PHQ-9). Multiple logistic regression analysis was used to calculate odds ratios (ORs) and 95% CIs for potential depressive symptom factors.

Results

Mild depressive symptoms and above are present in 21.12% of college students. Women had a higher prevalence of mild depressive symptoms than men (61.38 vs. 59.75%), and depressive symptoms were most prevalent among rural students and least prevalent among city students (21.44 vs. 20.29%). Participants with depressive symptoms are also more likely to have a poor-behavioral status. From none-to-severe depressive symptoms, 78.88, 15.78, 2.80, 1.67, and 0.88% had them. Gender, residential location, and behavioral status were found to be associated with depressive symptoms after adjusting for potential confounders.

Conclusion

This cross-sectional study identified the factors that influence the prevalence of depression in college students. It found that the government should pay more attention to mental health issues affecting college students in combating the COVID-19 epidemic normalization.
Impact of deamidation on the physicochemical properties and air-water interfacial behaviour of gliadin nanoparticles
Authors: Moraveji Maryam , Sadat Azin , Joye Iris J.
Published: August 2022

Gliadin due to its low water solubility is excellently suited to make biopolymeric nanoparticles through liquid antisolvent precipitation. These gliadin nanoparticles (GNPs) can be utilized to populate and stabilize interfaces. Gliadin, by nature a protein that carries a low charge, can be altered by deamidation. Deamidation effectively alters the physicochemical properties of gliadin through decreasing the protein’s isoelectric point (IEP). The objective of this study is to explore the effect of different degrees of deamidation on gliadin nanoparticle (interfacial) characteristics. Besides altering the physical stability of GNP suspensions, deamidation did alter the functionality of GNPs as interfacial agents. GNP behaviour at the air-water interface is substantially impacted by pH. Particles made with untreated and deamidated gliadin exhibited a greater tendency to adsorb and form strong viscoelastic films at the air-water interface and better foam structures closer to their IEP. The combination of SEM, confocal Raman microscopy and drop tensiometry provides unique insights in the dominant gliadin structures and interactions at the interfacial film. This study provides crucial insights into the potential of deamidation to tailor gliadin and GNP properties for specific food applications.
Transcriptome sequencing reveals differences between leydig cells and sertoli cells of yak
Authors: Wang Yaying , Pan Yangyang , Wang Meng , Afedo Seth Yaw , Zhao Ling , Han Xiaohong , Liu Minqing , Zhao Tian , Zhang Tongxiang , Ding Tianyi , Wang Jinglei , Cui Yan , Yu Sijiu
Published: August 2022

In this study, we detected the expression of mRNAs, lncRNAs, and miRNAs in primary cultured leydig cells (LCs) and sertoli cells (SCs) of yak by RNA sequencing technology. A total of 84 differently expression mRNAs (DEmRNAs) (LCs vs. SCs: 15 up and 69 down), 172 differently expression lncRNAs (DElncRNAs) (LCs vs. SCs: 36 up and 136 down), and 90 differently expression miRNAs (DEmiRNAs) (LCs vs. SCs: 72 up and 18 down) were obtained between the two types of cells. GO enrichment and KEGG analysis indicated that the differential expression genes (DEGs) were more enriched in the regulation of actin cytoskeleton, Rap1/MAPK signaling pathway, steroid biosynthesis, focal adhesion, and pathways associated with metabolism. Targeted regulation relationship pairs of 3β-HSD and MSTRG.54630.1, CNTLN and MSTRG.19058.1, BRCA2 and MSTRG.28299.4, CA2 and novel-miR-148, and ceRNA network of LAMC3-MSTRG.68870.1- bta-miR-7862/novel-miR-151/novel-miR-148 were constructed by Cytoscape software. In conclusion, the differences between LCs and SCs were mainly reflected in steroid hormone synthesis, cell proliferation and metabolism, and blood-testicular barrier (BTB) dynamic regulation, and 3β-HSD, CNTLN, BRCA2, CA2, and LAMC3 may be the key factors causing these differences, which may be regulated by ncRNAs. This study provides a basic direction for exploring the differential regulation of LCs and SCs by ncRNAs.
Effects of lipoteichoic and arachidonic acids on the immune-regulatory mechanism of bovine mammary epithelial cells using multi-omics analysis
Authors: Dong Weitao , Chen Yan , Zhang Quanwei , Zhao Xiaoxuan , Liu Peiwen , He Haijian , Lu Ting , He Yuxuan , Du Xianghong , Hu Junjie , Zhao Xingxu , Zhang Yong
Published: August 2022

Staphylococcus aureus is one of the most important pathogens causing mastitis in dairy cows. It mainly utilizes the properties of its pathogenic factor, lipoteichoic acid (LTA), to elicit a host-cell inflammatory response and evade the host-cell immune response. Arachidonic acid (AA) has a regulatory role in the inflammatory response, cell metabolism, and apoptosis. The study aimed to establish a cell model by determining the optimal concentration of LTA and AA for cell induction using the Cell Counting Kit−8 assay and the quantitative polymerase chain reaction of interleukin (IL)-1β, IL-2, and IL-6. MAC-T cells were planted in 36 10-cm2 culture dishes at a density of 1 × 107 cells per dish. They were treated with LTA for 24 h to constitute the LTA group and with AA for 12 h to constitute the AA group. The cells were pretreated with LTA for 24 h followed by treatment with AA for 12 h to constitute the LTA + AA group. Using proteomic, transcriptomic, and metabolomic analyses, this study determined that LTA can regulate the expression of Actin Related protein 2/3 complex (ARPC)3, ARPC4, Charged Multivesicular Body Protein 3, protein kinase cGMP-dependent, NF-κB Inhibitor Alpha,and other genes to affect cellular metabolism, immune regulation and promote apoptosis. In contrast, AA was observed to regulate the expression of genes such as ARPC3, ARPC4, Charged Multivesicular Body Protein 3, Laminin Gamma 1, Insulin Receptor, Filamin B, and Casein Kinase 1 Epsilon to inhibit cellular apoptosis and promote immune regulation, which provides a theoretical basis for future studies.
Gender Gap in Unhealthy Life Expectancy: The Role of Education Among Adults Aged 45+
Authors: Solé-Auró Aïda , Zueras Pilar , Lozano Mariona , Rentería Elisenda
Published: August 2022

Objectives: This paper examines the gender gap in unhealthy life expectancy across education levels and age in Spain to understand the extent to which the gender paradox exists over education and across ages.

Methods: Death registrations and vital status were taken from the Spanish Statistical Office, while the three health measures (chronic conditions, bad-self rated health and cognitive impairment) from the 2019 European Health Interview Survey. We used Sullivan’s method to compute unhealthy life expectancy by education level. We computed the gender and the education ratios of the proportion of unhealthy life years in each health measure by education and age.

Results: At almost all ages and all education levels, women significantly lived longer but in poorer health than men. Marked gender differences are seen across most age-groups, particularly among the low educated. We detected greater health inequalities by education level for women (confirming the gender paradox) and a health gradient due to aging and across the health measures charting the disablement process.

Conclusion: The new education distribution might improve the unhealthy life expectancy and might reduce the gender gap in the number of years spent in poor health.
Filtering and Estimation of State and Wind Disturbances Aiming Airship Control and Guidance
Authors: Marton Apolo Silva , Azinheira José Raul , Fioravanti André Ricardo , De Paiva Ely Carneiro , Carvalho José Reginaldo H , Costa Ramiro Romankevicius
Published: August 2022

Good state and wind estimation is a requirement for the development of guidance and control techniques for airships. However, usually this information is not directly available from the airship sensors. The typical solution applies filtering, estimation and sensor fusion methods. This paper presents a comparative study, evaluating three solutions for the state estimation of NOAMAY airship. We also present alternative versions for the crucial estimation of the wind velocity, combining Kalman filters with a data-driven Neural Network. Finally, we present special solutions to usual problems encountered in filtering implementation as the mitigation of delays caused by second-order filters. The sensors set considered is composed of a global positioning system, an inertial measurement unit and a one-dimensional Pitot probe. Comparative simulation results are presented with the use of a realistic nonlinear model of the airship.
Hoof Impact and Foot-Off Accelerations in Galloping Thoroughbred Racehorses Trialling Eight Shoe–Surface Combinations
Authors: Horan Kate , Coburn James , Kourdache Kieran , Day Peter , Carnall Henry , Brinkley Liam , Harborne Dan , Hammond Lucy , Peterson Mick , Millard Sean , Pfau Thilo
Published: August 2022

The athletic performance and safety of racehorses is influenced by hoof–surface interactions. This intervention study assessed the effect of eight horseshoe–surface combinations on hoof acceleration patterns at impact and foot-off in 13 galloping Thoroughbred racehorses retired from racing. Aluminium, barefoot, GluShu (aluminium–rubber composite) and steel shoeing conditions were trialled on turf and artificial (Martin Collins Activ-Track) surfaces. Shod conditions were applied across all four hooves. Tri-axial accelerometers (SlamStickX, range ±500 g, sampling rate 5000 Hz) were attached to the dorsal hoof wall (x: medio-lateral, medial = positive; y: along dorsal hoof wall, proximal = positive; and z: perpendicular to hoof wall, dorsal = positive). Linear mixed models assessed whether surface, shoeing condition or stride time influenced maximum (most positive) or minimum (most negative) accelerations in x, y and z directions, using ≥40,691 strides (significance at p < 0.05). Day and horse–rider pair were included as random factors, and stride time was included as a covariate. Collective mean accelerations across x, y and z axes were 22–98 g at impact and 17–89 g at foot-off. The mean stride time was 0.48 ± 0.07 s (mean ±2 SD). Impact accelerations were larger on turf in all directions for forelimbs and hindlimbs (p ≤ 0.015), with the exception of the forelimb z-minimum, and in absolute terms, maximum values were typically double the minimum values. The surface type affected all foot-off accelerations (p ≤ 0.022), with the exception of the hindlimb x-maximum; for example, there was an average increase of 17% in z-maximum across limbs on the artificial track. The shoeing condition influenced all impact and foot-off accelerations in the forelimb and hindlimb datasets (p ≤ 0.024), with the exception of the hindlimb impact y-maximum. Barefoot hooves generally experienced the lowest accelerations. The stride time affected all impact and foot-off accelerations (p < 0.001). Identifying factors influencing hoof vibrations upon landing and hoof motion during propulsion bears implication for injury risk and racing outcomes.
Bending Stresses and Deformations in Prismatic Profiled Shafts with Noncircular Contours Based on Higher Hybrid Trochoids
Authors: Ziaei Masoud
Published: August 2022

This paper presents an analytical method for determining the bending stresses and deformations in prismatic, noncircular profile shafts with trochoidal cross sections. The so-called higher trochoids can be used as form-fit shaft-hub connections. Hybrid (mixed) higher trochoids (M-profiles) were developed for the special application as a profile contour for the form-fit shaft and hub connections in an earlier work by the author. M-profiles combine the advantages of the two standardised polygonal and spline contours, which are used as shaft-hub connections for the transmission of high torques. In this study, the geometric and mechanical properties of the higher hybrid trochoids were investigated using complex functions to simplify the calculations. The pure bending stress and shaft deflection were determined for M-profiles using bending theory based on the theory of mathematical elasticity. The loading cases consisted of static and rotating bends. Analytical, numerical, and experimental results agreed well. The calculation formulas developed in this work enable reliable and low-cost dimensioning with regard to the stresses and elastic deformations of profile shafts subjected to bending loads.
Study of the Mesosphere and Lower Thermosphere by the Method of Creating Artificial Periodic Irregularities of the Ionospheric Plasma
Authors: Bakhmetieva Nataliya V. , Grigoriev Gennadiy I.
Published: August 2022

This article presented a brief review of studies of the Earth’s ionosphere at the heights of the mesosphere and lower thermosphere by a method based on the creation of artificial periodic inhomogeneities (APIs) of the ionospheric plasma by high-frequency radiation from powerful thermal installations. APIs are created by a standing wave due to the interference between upward-propagating radio waves and those reflected from the ionosphere. API studies of the ionosphere were based on Bragg scattering of probing impulse signals from an artificial periodic structure. The method makes it possible to measure the parameters of the neutral and ionized components of the Earth’s atmosphere. Note that, despite the fact that the API method assumes an artificial perturbation of the ionospheric plasma, the parameters of the mesosphere and lower thermosphere are determined at the stage of inhomogeneity relaxation and characterize the undisturbed medium. To date, periodic inhomogeneities have been observed at the heating points of Zimenki and Sura ionospheric heating facility (SURA, Vasilsursk, Russia), Gissar (Tajikistan), Arecibo (Puerto Rico, USA), High Power Auroral Stimulation Observatory (HIPAS) and High Frequency Active Auroral Research Program (HAARP, Gakona, AK, USA), and European Incoherent Scatter (EISCAT, Tromso, Norway). Most of the API studies of the ionosphere were carried out at the SURA mid-latitude heating facility (56.1° N; 46.1° E). The review presented the main results of determining the parameters of the ionosphere and neutral atmosphere at altitudes of 60–120 km and studies of the atmosphere during sunrise and sunset events and solar eclipses. In fact, the review is far from a complete illustration of the possibilities of using the API method to study the mesosphere and lower thermosphere.
Predicting Coordination Variability of Selected Lower Extremity Couplings during a Cutting Movement: An Investigation of Deep Neural Networks with the LSTM Structure
Authors: Shao Enze , Mei Qichang , Ye Jingyi , Ugbolue Ukadike C. , Chen Chaoyi , Gu Yaodong
Published: August 2022

There are still few portable methods for monitoring lower limb joint coordination during the cutting movements (CM). This study aims to obtain the relevant motion biomechanical parameters of the lower limb joints at 90°, 135°, and 180° CM by collecting IMU data of the human lower limbs, and utilizing the Long Short-Term Memory (LSTM) deep neural-network framework to predict the coordination variability of selected lower extremity couplings at the three CM directions. There was a significant (p < 0.001) difference between the three couplings during the swing, especially at 90° vs the other directions. At 135° and 180°, t13-he coordination variability of couplings was significantly greater than at 90° (p < 0.001). It is important to note that the coordination variability of Hip rotation/Knee flexion-extension was significantly higher at 90° than at 180° (p < 0.001). By the LSTM, the CM coordination variability for 90° (CMC = 0.99063, RMSE = 0.02358), 135° (CMC = 0.99018, RMSE = 0.02465) and 180° (CMC = 0.99485, RMSE = 0.01771) were accurately predicted. The predictive model could be used as a reliable tool for predicting the coordination variability of different CM directions in patients or athletes and real-world open scenarios using inertial sensors.
Deciphering the Biological Effects of Radiotherapy in Cancer Cells
Authors: Lu Zhou , Zheng Xueting , Ding Chenghe , Zou Zhiyan , Liang Yuanyuan , Zhou Yan , Li Xiaoan
Published: August 2022

Radiotherapy remains an effective conventional method of treatment for patients with cancer. However, the clinical efficacy of radiotherapy is compromised by the development of radioresistance of the tumor cells during the treatment. Consequently, there is need for a comprehensive understanding of the regulatory mechanisms of tumor cells in response to radiation to improve radiotherapy efficacy. The current study aims to highlight new developments that illustrate various forms of cancer cell death after exposure to radiation. A summary of the cellular pathways and important target proteins that are responsible for tumor radioresistance and metastasis is also provided. Further, the study outlines several mechanistic descriptions of the interaction between ionizing radiation and the host immune system. Therefore, the current review provides a reference for future research studies on the biological effects of new radiotherapy technologies, such as ultra-high-dose-rate (FLASH) radiotherapy, proton therapy, and heavy-ion therapy.
Exploring the Dynamics of Shikimate Kinase through Molecular Mechanics
Authors: Ojeda-May Pedro
Published: August 2022

Shikimate kinase (SK) enzyme is a suitable target for antimicrobial drugs as it is present in pathogenic microorganisms and absent in mammals. A complete understanding of the functioning of this enzyme can unveil novel methods to inactivate it. To do this, a clear understanding of SK performance is needed. Previously, the chemical step of SK was studied in detail, but a study of longer-term scale simulations is still missing. In the present work, we performed molecular dynamics (MD) simulations in the μs time scale that allowed us to explore further regions of the SK energy landscape than previously. Simulations were conducted on the wild-type (WT) enzyme and the R116A and R116K mutants. We analyzed the dynamics of the enzymes through standard MD tools, and we found that the global motions in the mutants were perturbed. These motions can be linked to the observed undetectable binding affinity of the WT enzyme and the R116A and R116K mutants.
The Extracellular Matrix Environment of Clear Cell Renal Cell Carcinoma
Authors: Oxburgh Leif
Published: August 2022

The extracellular matrix (ECM) of tumors is a complex mix of components characteristic of the tissue of origin. In the majority of clear cell renal cell carcinomas (ccRCCs), the tumor suppressor VHL is inactivated. VHL controls matrix organization and its loss promotes a loosely organized and angiogenic matrix, predicted to be an early step in tumor formation. During tumor evolution, cancer-associated fibroblasts (CAFs) accumulate, and they are predicted to produce abundant ECM. The ccRCC ECM composition qualitatively resembles that of the healthy kidney cortex in which the tumor arises, but there are important differences. One is the quantitative difference between a healthy cortex ECM and a tumor ECM; a tumor ECM contains a higher proportion of interstitial matrix components and a lower proportion of basement membrane components. Another is the breakdown of tissue compartments in the tumor with mixing of ECM components that are physically separated in healthy kidney cortex. Numerous studies reviewed in this work reveal effects of specific ECM components on the growth and invasive behaviors of ccRCCs, and extrapolation from other work suggests an important role for ECM in controlling ccRCC tumor rigidity, which is predicted to be a key determinant of invasive behavior.
Temsirolimus Enhances Anti-Cancer Immunity by Inducing Autophagy-Mediated Degradation of the Secretion of Small Extracellular Vesicle PD-L1
Authors: Park Seong-Sik , Kim Jong-In , Lee Chan-Hyeong , Bae Ju-Hyun , Park Ju-Mi , Choe Eun-Ji , Baek Moon-Chang
Published: August 2022

Tumor-derived small extracellular vesicle (sEV) programmed death-ligand 1 (PD-L1) contributes to the low reactivity of cells to immune checkpoint blockade therapy (ICBT), because sEV PD-L1 binds to programmed death 1 (PD-1) in immune cells. However, there are no commercially available anti-cancer drugs that activate immune cells by inhibiting tumor-derived sEV PD-L1 secretion and cellular PD-L1. Here, we aimed to investigate if temsirolimus (TEM) inhibits both sEV PD-L1 and cellular PD-L1 levels in MDA-MB-231 cells. In cancer cell autophagy activated by TEM, multivesicular bodies (MVBs) associated with the secretion of sEV are degraded through colocalization with autophagosomes or lysosomes. TEM promotes CD8+ T cell-mediated anti-cancer immunity in co-cultures of CD8+ T cells and tumor cells. Furthermore, the combination therapy of TEM and anti-PD-L1 antibodies enhanced anti-cancer immunity by increasing both the number and activity of CD4+ and CD8+ T cells in the tumor and draining lymph nodes (DLNs) of breast cancer-bearing immunocompetent mice. In contrast, the anti-cancer effect of the combination therapy with TEM and anti-PD-L1 antibodies was reversed by the injection of exogenous sEV PD-L1. These findings suggest that TEM, previously known as a targeted anti-cancer drug, can overcome the low reactivity of ICBT by inhibiting sEV PD-L1 and cellular PD-L1 levels.
Behavior Problems among Children of Mothers with Mild Intellectual Disability: The Role of Maternal Sensitivity, Trauma History, and Intelligence
Authors: Forslund Tommie , Lindberg Lene , Granqvist Pehr
Published: August 2022

Children of parents with intellectual disability (ID) are at risk of behavior problems, but few studies have systematically examined contributions from caregiving behavior and contextual factors. This cross-sectional matched comparison study examined whether the children display elevated behavior problems, and analyzed contributions from maternal sensitivity and maternal experiences of abuse, trauma and maltreatment (ATM). The roles of maternal and child intelligence were also examined. Participants were 26 mothers with mild ID and their children (mean age = 79 months; 58% boys), and 26 socioeconomically matched comparison dyads. Child behavior problems were assessed with maternal ratings, maternal sensitivity with structured observations, and maternal experiences of ATM with semi-structured interviews. Maternal intelligence was measured with a subtest from Wechsler Adult Intelligence Scales (WAIS-III), and child intelligence with the IQ-screen in Leiter-R. Children of mothers with ID had higher ratings on psychosomatic, anger, hyperactivity, and total problems, but not on anxiety. Sensitivity was negatively associated with anger, hyperactivity, and total child behavior problems. Maternal ATM was positively linked to child anger problems. Maternal intelligence was unrelated to child behavior problems, but low child intelligence marginally predicted behavior problems. Inclusion and equity for parents with ID and their children require that clinical practice boost sensitivity, especially among parents who have experienced ATM.
Logical Entropy of Information Sources
Authors: Xu Peng , Sayyari Yamin , Butt Saad Ihsan
Published: August 2022

In this paper, we present the concept of the logical entropy of order m, logical mutual information, and the logical entropy for information sources. We found upper and lower bounds for the logical entropy of a random variable by using convex functions. We show that the logical entropy of the joint distributions X1 and X2 is always less than the sum of the logical entropy of the variables X1 and X2. We define the logical Shannon entropy and logical metric permutation entropy to an information system and examine the properties of this kind of entropy. Finally, we examine the amount of the logical metric entropy and permutation logical entropy for maps.
Carbon-α-Fe2O3 Composite Active Material for High-Capacity Electrodes with High Mass Loading and Flat Current Collector for Quasi-Symmetric Supercapacitors
Authors: Najafi Maedeh , Bellani Sebastiano , Galli Valerio , Zappia Marilena Isabella , Bagheri Ahmad , Safarpour Milad , Beydaghi Hossein , Eredia Matilde , Pasquale Lea , Carzino Riccardo , Lauciello Simone , Panda Jaya-Kumar , Brescia Rosaria , Gabatel Luca , Pellegrini Vittorio , Bonaccorso Francesco
Published: August 2022

In this work, we report the synthesis of an active material for supercapacitors (SCs), namely α-Fe2O3/carbon composite (C-Fe2O3) made of elongated nanoparticles linearly connected into a worm-like morphology, by means of electrospinning followed by a calcination/carbonization process. The resulting active material powder can be directly processed in the form of slurry to produce SC electrodes with mass loadings higher than 1 mg cm−2 on practical flat current collectors, avoiding the need for bulky porous substrate, as often reported in the literature. In aqueous electrolyte (6 M KOH), the so-produced C-Fe2O3 electrodes display capacity as high as ~140 mAh g−1 at a scan rate of 2 mV s−1, while showing an optimal rate capability (capacity of 32.4 mAh g−1 at a scan rate of 400 mV s−1). Thanks to their poor catalytic activity towards water splitting reactions, the electrode can operate in a wide potential range (−1.6 V–0.3 V vs. Hg/HgO), enabling the realization of performant quasi-symmetric SCs based on electrodes with the same chemical composition (but different active material mass loadings), achieving energy density approaching 10 Wh kg−1 in aqueous electrolytes.
Modelling Structural Effect and Linkage on Carbon Emissions in China: An Environmentally Extended Semi-Closed Ghosh Input–Output Model
Authors: Nie Yongyou , Gao Yunhuan , He He
Published: August 2022

The carbon emissions of sectors and households enabled by primary inputs have practical significance in reality. Considering the mutual effect between the industrial sector and the household, this paper firstly constructed an environmentally extended semi-closed Ghosh input–output model with an endogenized household sector to analyze the relationship between carbon emissions and the Chinese economy from the supply-side perspective. The structural decomposition analysis and the hypothetical extraction method were remodified to identify the supply-side driving effects of the changes in carbon emissions and investigate the net carbon linkage. The results show that the electricity, gas, and water supply sector was the key sector with the highest carbon emission intensity enabled by primary inputs. The household sector had an above 93% indirect effect of the enabled intensity, with its enabled intensity dropping significantly by more than 55% from 2007 to 2017. The operating surplus and mixed income caused 3214.67 Gt (34.17%) of the enabled emissions in 2017. The supply-side economic activity, measured by the value added per capita, was the main factor of the carbon emission growth, mainly attributed to the development of the manufacturing sector and the electricity, gas, and water supply sector. The emission intensity and allocation structure both brought a decrease in carbon emissions. The electricity, gas, and water supply sector and the manufacturing sector were the major sources of the supply-induced cross-sectoral input emissions, while the commercial and service sector and the household sector were the top source of supply-induced cross-sectoral output emissions. This paper sheds light on the policies of the carbon emission abatement and the adjustment of the allocation structure from the perspective of supply.
Microgrid Harmonic Mitigation Strategy Based on the Optimal Allocation of Active Power and Harmonic Mitigation Capacities of Multi-Functional Grid-Connected Inverters
Authors: Wang Ning , Zheng Shuai , Gao Weiqiang
Published: August 2022

Harmonic pollution sources in microgrids have the characteristics of high penetration and decentralization, as well as forming a full network. Local harmonic mitigation is a traditional harmonic mitigation method, which has the disadvantages of complexity and costly operation. Based on the idea of the decentralized autonomy of power quality, this paper establishes a comprehensive optimization model of the active power and harmonic mitigation capacities of grid-connected inverters based on two-layer optimization and realizes harmonic mitigation. Firstly, based on the harmonic sensitivity analysis, the calculation method of harmonic mitigation capacity is given. Secondly, a two-layer model of harmonic mitigation optimization is established. The upper-layer optimization model takes the minimum operation cost of the microgrid as the objective and the active power reduction in the multi-functional grid-connected inverter (MFGCI) as the optimization variable. The lower-layer optimization model offers the best harmonic mitigation effect as the objective and the harmonic current compensation as the optimization variable. According to the relationship between the total remaining capacity of MFGCI and the capacity required for harmonic mitigation, there are three different objective functions in the lower-layer optimization model. Then, the model solving steps are provided. Finally, an example shows that the proposed optimization model can achieve harmonic mitigation at different times. Compared with the case without active power optimization, the operation cost of the whole system can be reduced by up to 14.6%, while ensuring the harmonic mitigation effect. The proposed method has the advantages of a harmonic mitigation effect and economical system operation.
Modified Activated Carbon as an Effective Hydrogen Adsorbent
Authors: Baran Paweł , Buczek Bronisław , Zarębska Katarzyna
Published: August 2022

Hydrogen adsorption measurements were taken by the weighting method using the Sartorius low-pressure microbalance. Experiments were conducted at two temperatures: 77.5 and 300 K; the adsorbent used was active carbon obtained from wood and modified with potassium hydroxide. The porous structure of the carbon prior to and after modification was evaluated based on the nitrogen adsorption and desorption data. Thus, the densimetric characteristic of active carbon was modified; porous structures were developed in the range of micro-, meso- and macropores and the volume of hydrogen adsorbed at 77.5 K showed an almost four-fold increase. Modified active carbons are found to be suitable for applications in hydrogen storage systems.
The Change in Growth, Osmolyte Production and Antioxidant Enzymes Activity Explains the Cadmium Tolerance in Four Tree Species at the Saplings Stage
Authors: Zafar Zikria , Rasheed Fahad , Khan Waseem Razzaq , Mohsin Muhammad , Rashid Muhammad Zahid , Magiman Mohamad Maulana , Raza Zohaib , Rosli Zamri , Afzal Shazia , Bakar Fauziah Abu
Published: August 2022

Phytoremediation is a green technology; however, very few species of arid environments have been identified as hyperaccumulators and fast growers. Therefore, a greenhouse experiment was performed to evidence the phytoaccumulation potential of Conocarpus erectus, Syzygium cumini, Populus deltoides and Morus alba at the sapling stage. Six-month-old plant saplings were subjected to control (CK; 0 µM) and cadmium treatments (Cd; CdCl2; 200 µM). The results depicted that plant growth, dry biomass production (leaf and stem) and chl a, b and carotenoid contents decreased significantly in all four species under Cd treatment; however, the lowest decrease was evidenced in Conocarpus erectus. The concentration of hydrogen peroxide and superoxide radical increased significantly in all four species, with the highest increase observed in Morus alba. Osmolytes production, antioxidant enzymes activity (superoxide dismutase, peroxidase, catalase and ascorbate peroxidase) and Cd accumulation in the leaves, stem and root increased significantly in all four species under Cd treatment, with the highest increase observed in Conocarpus erectus. The translocation factor was >1 in Conocarpus erectus, Syzyngoim cumini and Populus deltoides and was <1 in Morus alba. The study revealed a better Cd tolerance in Conocarpus erectus, which was driven by the effective osmolyte balance and antioxidant enzymes mechanism.
Optimization and Implementation of Fed-Batch Strategy to Produce Ligninolytic Enzyme from the White-Rot Basidiomycete Pycnoporus sanguineus in Bubble Column Reactor
Authors: de Souza Evanildo F. , Santos Isabella M. T. S. , Souto Felipe , Calado Verônica , Pereira Nei
Published: August 2022

The current work evaluates the production of ligninolytic enzyme optimization via response surface methodology using different inducers: acid cellulignin (CA); MnSO4 (Mn2+); CuSO4·5H2O (Cu2+); veratryl (3, 4-dimethoxybenzyl); alcohol (VA); Tween 80% (T80); and the carbon-to-nitrogen ratio (C/N). A further goal was implementing a fed-batch strategy to produce ligninolytic enzyme extracts from P. sanguineus 2512 using a bubble column reactor (BCR). The best optimized experimental condition in the shake flasks was a 7.5 C/N ratio, 0.025 g/L Cu2+, 1.5 mM Mn2+, 3.0 mM VA and 0.025 mM T80, resulting in 64,580, 9.10 and 80.72 U/L for Laccase (Lac), Manganese (MnP) and Lignin peroxidase (LiP) activities, respectively. In the BCR, three feedings were performed at 24 h intervals on the 6th, 7th and 8th days with a significant increase in Lac (99,600 U/L) and MnP (47.53 U/L) activities on the 8th day and a reduction on the 9th day of cultivation. The LiP activity peak was achieved on the 5th day (416 U/L) of cultivation, decreasing thereafter. Enzyme cocktails concentrated in hollow fiber in the third cultivation batch showed contents of 4 × 105 U/L, 220 U/L and 2.5 g/L for Lac, MnP and total proteins, respectively. The enzymatic cocktail with the highest LiP activity (1200 U/L) was obtained in the first batch. The results showed that the optimization of the biosynthesis of the ligninolytic enzymes provided satisfactory improvement in terms of Lac and MnP production per run.
The Potential Use of Endophyte-Free inebrians as Sheep Feed Evaluated with In Vitro Fermentation
Authors: Ma Yaling , Wang Hucheng , Li Chunjie , Malik Kamran
Published: August 2022

Endophytic fungal infection is the major reason for intoxication of animals caused by drunken horse grass. Fortunately, it has been established that seed detoxification techniques and isolation of endophytic fungi infect non-endophytic fungi populations with the same genetic background as endophyte-infected Achnatherum inebrians. Moreover, sheep can use endophyte-free Achnatherum inebriants (EF) without obvious toxicity symptoms. The present study selected EF as a representative grass, consisting of five different replacement levels, EF0, EF25, EF50, EF75, and EF100, corresponding to 0%, 25%, 50%, 75%, and 100% of the fermentation substrate, respectively. Simultaneously, in vitro fermentation and the 16S rRNA amplicon sequencing method was used to explore the effect of EF on sheep ruminal fermentation and microbial diversity. The results revealed that EF100 had the highest values for pH, acetate: propionate, the Patescibacteria, Kiritimatiellaeota, and Synergistetes phylum levels, Ruminococcaceae, Prevotellaceae, and Saccharofermentans genus levels than the other treatments (p < 0.05). In contrast, EF25 was associated with higher levels of abundance-based coverage estimator (ACE), Chaol index of the phyla Synergistetes and Bacteroidetes, and of the genus Erysipelotrichaceae, Rikenellaceae, and Prevotella as compared with other treatments (p < 0.05). EF50 resulted in the greatest values for the genus Christensenellaceae and Lachnospiraceae as compared with other treatments (p < 0.05). EF75 resulted in the greatest values for the Shannon index as compared with other treatments (p < 0.05). EF0 resulted in the greatest values for gas production (GP), ammonia nitrogen (NH3-N), total volatile fatty acid (TVFA), acetate, propionate, butyrate, valerate, isobutyrate, isovalerate, and the phyla Firmicutes, Proteobacteria, and Spirochaetes, and the genus Succiniclasticum, Ruminobacter, Family_XIII and Treponema as compared with other treatments (p < 0.05). PICRUSt2 analysis indicated that most of the functional prediction pathways were involved in Carbohydrate metabolism and, Amino acid metabolism. Therefore, the recommended ratio of EF in sheep diet should range from 25% to 50%, and the maximum proportion should not exceed 75%.
Common Single Nucleotide Polymorphism of TMPRSS6, an Iron Regulation Gene, Associated with Variable Red Blood Cell Indices in Deletional α-Globin Genotypes
Authors: Suksangpleng Thidarat , Glomglao Waraporn , Viprakasit Vip
Published: August 2022

Red blood cell (RBC) indices, including mean corpuscular volume (MCV) and mean corpuscular haemoglobin (MCH), have been widely used for primary screening for thalassaemia (thal) syndromes. Recently, a single nucleotide polymorphism (SNP) rs855791 of TMPRSS6, an iron regulation gene involved in the substitution of a nucleotide between thymine (T) and cytosine (C) in exon 17 resulted in an amino acid change, p.Val736Ala (V736A), has been described to associate with RBC indices. The objective was to study the effects of common SNP V736A on RBC indices in deletional α-thal variations. SNP rs855791 genotypes were identified from 433 Thai volunteers, including 32.6% males and 67.4% females with an average age of 23.0 ± 8.7 years. These populations included individuals (82.4%) who had normal globin genotype (αα/αα, ββ) and α-thal carriers, which were divided into two subgroups, including α+-thal (-α/αα) (14.1%) and αo-thal (--/αα) (3.5%). Among three SNP genotypes, the C allele gradually expressed higher MCV and MCH than those of the T allele in both α+- and αo-thal traits. Importantly, SNP rs855791 of TMPRSS6 responded to α-globin deletions for sustaining RBC sizes and haemoglobinisation in α-thal carriers.
Food Bolus Properties in Relation to Dentate and Prosthetic Status
Authors: Preoteasa Elena , Oncescu Moraru Alexandra Melania , Meghea Daniela , Murariu Magureanu Catalina , Preoteasa Cristina Teodora
Published: August 2022

The objective of this study is to evaluate food bolus properties (mass, moisture content and food comminution) in patients wearing fixed or removable dental prostheses. Methods: A cross-sectional study was conducted on a convenience sample of patients aged at least 55 years old. Patients chewed a 10 g sample of fresh raw carrot until they felt ready to swallow. The mass of the food bolus was determined as collected and after drying. Food comminution was assessed by the multiple sieve method. Results: Patients with fixed prostheses compared to those with removable prostheses registered a similar mass of food bolus as collected (4.40 g vs. 4.60 g; p = 0.856); a higher mass of dried food bolus (3.46 g vs. 0.86 g; p < 0.001); lower moister of food bolus (24.65% vs. 82.35%; p < 0.001); and better food comminution (mass of smaller particles, of size below 2 mm, represented 65.93% vs. 20% of dried food bolus). In removable denture wearers, food comminution was slightly better in partially than in completely edentulous patients, and rather similar in completely edentulous patients with either implant overdenture or complete denture in the mandible, and complete denture in the maxilla. Conclusions: The current results suggest that food bolus properties are dependent on the dentate and prosthetic status.
“Back into Life—With a Power Wheelchair”: Learning from People with Severe Stroke through a Participatory Photovoice Study in a Metropolitan Area in Germany
Authors: Böttger Tabea , Dennhardt Silke , Knape Julia , Marotzki Ulrike
Published: August 2022

Severe stroke leads to permanent changes in everyday life. Many stroke survivors depend on support in community mobility (CM). This leads to restrictions and limited social participation. A power wheelchair (PWC) can enable independent CM and reduce such restrictions. This participatory study focused on how people with severe stroke experience their CM in a PWC in Berlin/Germany and what changes they want to initiate. A research team of five severe stroke survivors and two occupational therapists examined the question using photovoice. Stroke survivors took photos of their environment, presented, discussed, and analyzed them at group meetings to identify themes, and disseminated their findings at exhibitions and congresses. The photos emphasize the significance of and unique relationship to the PWC for the self-determined expression of personal freedom. As a complex, individualized construct, CM requires an accessible environment and diverse planning strategies by PWC users to arrive at their destination and overcome suddenly occurring obstacles. Desired changes stress CM independent of external help, increased social esteem, and active involvement in the provision of assistive devices. Voices of severe stroke survivors need to be heard more in healthcare and research to ensure the possibility of equal social participation.