bluuebunny/crossref_metadata_2025 huggingface dataset:
POTENSI KARBON TERSIMPAN PADA TEGAKAN PINUS (PINUS MERKUSII) DI BLOK PASIR BATANG KAWASAN TAMAN NASIONAL GUNUNG CIREMAI
Authors: Nurfansyah Erwin , Hendrayana Yayan , Adhya Ilham
Published: March 2024

ABSTRAK. Mengingat peran penting hutan dalam menyerap karbon dari udara, maka perlu dilakukan banyak penelitian untuk mendukung pengembangan lebih lanjut penyerapan karbon dalam biomassa. Penelitian ini bertujuan untuk mengetahui potensi cadangan karbon pada tegakan pinus di Blok Pasir Batang Kawasan Taman Nasional Gunung Ciremai. Metode yang digunakan adalah non destructive sampling yaitu cara pengambilan sampel yang ramah lingkungan. Terdapat pohon pinus di areal seluas 30 hektar sebanyak 24.060 batang. Diameter tegakan umur 25 tahun pohon pinus sekitar 28,32 cm dengan kerapatan relatif tinggi 0,027 individu/m2 sama dengan 267,3 individu/hektar. Perkiraan volume tegakan per hektar adalah 708,07 m3/hektar. Volume seluruh tegakan adalah 21.242,1 m3. Berdasarkan hasil penelitian diketahui bahwa jumlah biomassa tegakan di seluruh petak contoh adalah 36,04 ton/hektar atau total luasan 1.081,2 ton. Jumlah karbon dalam satu satuan luas adalah 16,9 ton/hektar atau seluruhnya 508,1 ton.Kata kunci: Biomassa, Metode non-destruktif , Penyerapan karbon, Pinus,
INVENTARISASI TANAMAN REHABILITASI DI WISATA ALAM PASIR BATANG KAWASAN TAMAN NASIONAL GUNUNG CIREMAI
Authors: Khotimah Helfia Noor , Adhya Ilham , Hendrayana Yayan
Published: March 2024

ABSTRAK. Tujuan penelitian ini adalah untuk mengetahui struktur vegetasi dan jenis tumbuhan rehabilitasi pada kawasan wisata alam Pasir Batang di kawasan Taman Nasional Gunung Ciremai (TNGC). Metode penelitian menggunakan metode jalur berpetak dengan ukuran petak 20 m x 20 m di sepanjang jalur penelitian. Berdasarkan hasil penelitian, Ditemukan 20 jenis tanaman rehabilitasi dari 10 famili. pada tingkat pertumbuhan semai di dominansi oleh jenis Kipirit, tingkat pertumbuhan pancang, tiang di dominansi oleh jenis yang sama yaitu Kisereuh (Cinnamomum parthenoxylon), dan pada tingkat pertumbuhan pohon di dominansi oleh jenis Alpukat (Persea americana).  Indeks keanekaragaman jenis tanaman rehabilitasi pada kawasan Wisata Alam Pasir Batang TNGC memiliki nilai H’ pada tingkat semai rendah, tingkat pancang rendah, tingkat tiang sedang, dan tingkat pohon rendahKata kunci: Inventarisasi, Rehabilitasi, struktur vegetasi, Wisata Alam Pasir Batang, TNGC.
ANALISIS KARAKTERISTIK ECO-ENZYME DARI BUAH TROPIS
Authors: Nurdin Nurdin , Nurlaila Ai , Herlina Nina , Rahardian Haydar
Published: March 2024

The increase in population is in line with the increase in the volume of waste every day. Garbage in the form of skins or seeds is classified as organic waste originating from pineapple (Ananas comosus), oranges (Citrus reticulata), bananas (Musa paradisiaca L. var sapientum) and watermelon (Citrullus lanatus) which are often found in the environment around settlements without any processing. One alternative for processing organic waste is to process it into a multipurpose solution called eco-enzyme. Eco-enzymes utilize fruit or vegetable waste as organic raw materials. Organic matter is mixed with sugar and water in a ratio of 10 parts water, 3 parts organic matter and 1 part brown sugar and then fermented for 90 days. The result is a concentrated acid eco-enzyme solution with a pH value of 3.2 and a TDS value of 2393.8. The percentage reduction of eco-enzyme products during the fermentation process ranges from 2-33% depending on the maturity level of the raw materialsPeningkatan populasi jumlah penduduk seiring dengan naiknya volume sampah setiap hari. Sampah berupa kulit atau biji tergolong sampah organik yang berasal dari buah nanas (Ananas comosus), jeruk (Citrus reticulata), pisang (Musa paradisiaca L. var sapientum) dan semangka (Citrullus lanatus) banyak ditemukan di lingkungan sekitar pemukiman tanpa adanya pengolahan. Salah satu alternatif pengolahan sampah organik yaitu dengan diproses menjadi larutan multiguna yang disebut eco-enzyme. Eco-enzyme memanfaatkan sampah buah-buahan atau sayuran sebagai bahan baku organik. Bahan organik dicampur dengan gula dan air dengan perbandingan10 bagian air, 3 bagian bahan organik dan 1 bagian gula merah lalu difermentasi selama 90 hari. Hasilnya berupa larutan eco-enzyme asam pekat dengan nilai pH 3,2 dan nilai TDS 2393,8. Prosentase pengurangan produk eco-enzyme pada saat proses fermentasi berkisar antara 2-33% tergantung pada tingkat kematangan bahan baku
ANALISIS POTENSI BURUNG UNTUK WISATA BIRDWATCHING DI KAWASAN GUNUNG TILU KABUPATEN KUNINGAN JAWA BARAT
Authors: Triliantho Seno , Herlina Nina , Nasihin Iing
Published: March 2024

This research aims to determine the diversity of bird species and the potential of bird species for birdwatching tourism in the Gunung Tilu area, Kuningan Regency, West Java Province. The method used in this research is field observation using the roaming method, namely by recording bird species encountered at each observation location. Recording of bird species uses the MacKinon species list method using 10 species in 1 list. Based on the results of observations in the field, 61 species of birds were found, with a total encounter of 1,439 individuals, with a total encounter on the valley route of 58 species and 633 individuals encountered, and on the ridge route there were 60 species found with a total encounter of 806 individuals. The bird species diversity index in the valley route has a value of H'=3.66. For the ridge path the value is H'=3.78. The Mount Tilu area has the potential for birdwatching tourism because it has 19 types of birds that have the potential for birdwatching tourism.Penelitian ini bertujuan untuk mengetahui keanekaragaman jenis burung dan potensi jenis burung untuk wisata birdwatching di kawasan Gunung Tilu Kabupaten Kuningan Provinsi Jawa Barat. Metode yang digunakan dalam penelitian ini adalah observasi lapangan dengan metode roaming yaitu dengan mencatat jenis-jenis burung yang ditemui pada setiap lokasi pengamatan. Pencatatan jenis burung menggunakan metode daftar jenis MacKinon dengan menggunakan 10 jenis dalam 1 daftar. Berdasarkan hasil pengamatan di lapangan ditemukan 61 jenis burung, dengan jumlah perjumpaan sebanyak 1.439 individu, dengan jumlah perjumpaan pada jalur lembah sebanyak 58 jenis dan ditemui 633 individu, serta pada jalur punggung bukit sebanyak 60 jenis. ditemukan dengan total pertemuan 806 individu. Indeks keanekaragaman jenis burung pada jalur lembah mempunyai nilai H'=3,66. Untuk jalur punggungan nilainya H'=3,78. Kawasan Gunung Tilu mempunyai potensi wisata birdwatching karena mempunyai 19 jenis burung yang berpotensi untuk wisata birdwatching.
STRATEGI PENGEMBANGAN HUTAN RAKYAT BERSERTIFIKAT DESA DUKUHDALEM KECAMATAN JAPARA KABUPATEN KUNINGAN JAWA BARAT Studi Kasus : Kelompok Tani Mekarsaluyu II
Authors: Nugraha Yogha Adhie , Hendrayana Yayan , Deni Deni
Published: March 2024

The problem with certified community forests is management problems, government policies that have not been optimal regarding certified community forests (There is a policy of P.85 / Menlhk / Setjen / Kum.1 / 11/2016) What used to be a certified community forest is mandatory now is not because for uncertified community forests, they can use transportation notes for their wood products), certified forest farmer groups are less in looking for opportunities, management is still traditional, and the existence of certificates does not guarantee easy selling of their wood products. For this reason, the method used in this research is to use the SWOT analysis technique of Freddy Rangkuti through direct interviews with resource persons, namely farmer group II and also with the Focus Group Disscussion method. The strategy for certified community forest management in Dukuhdalem Village, Japara District, Kuningan Regency by the Mekarsaluyu II Farmer Group, obtained an IFAS value of -0,113 and an EFAS value of 0,133 and the right strategy in developing a certified community forest management strategy in Dukuhdalem Village, Japara District, Kuningan Regency by the Mekarsaluyu II Farmer Group is an Turn Around strategy.Permasalahan hutan rakyat bersertifikat adalah permasalahan pengelolaan, kebijakan pemerintah yang belum optimal mengenai hutan rakyat bersertifikat (Ada kebijakan P.85/Menlhk/Setjen/Kum.1/11/2016) Yang dulunya merupakan hutan rakyat bersertifikat hutan menjadi wajib sekarang bukan karena bagi hutan rakyat yang belum bersertifikat, mereka bisa menggunakan nota angkut untuk hasil kayunya), kelompok tani hutan bersertifikat kurang dalam mencari peluang, pengelolaan masih tradisional, dan adanya sertifikat tidak menjamin mudahnya penjualan. produk kayu mereka. Untuk itu metode yang digunakan dalam penelitian ini adalah dengan menggunakan teknik analisis SWOT dari Freddy Rangkuti melalui wawancara langsung dengan narasumber yaitu kelompok tani II dan juga dengan metode Focus Group Discussion. Strategi pengelolaan hutan rakyat bersertifikat di Desa Dukuhdalem Kecamatan Japara Kabupaten Kuningan oleh Kelompok Tani Mekarsaluyu II memperoleh nilai IFAS sebesar -0,113 dan nilai EFAS sebesar 0,133 serta strategi yang tepat dalam menyusun strategi pengelolaan hutan rakyat bersertifikat di Dukuhdalem Desa, Kecamatan Japara, Kabupaten Kuningan oleh Kelompok Tani Mekarsaluyu II merupakan strategi Turn Around .
FAKTOR – FAKTOR PENENTU KEBERHASILAN PENANGKARAN EX-SITU MURAI BATU (Copsycus malabaricus, Scopoli) DI KABUPATEN KUNINGAN
Authors: Pratama Ilham , Supartono Toto , Nurdin Nurdin
Published: March 2024

The purpose of this study was to determine the determinants of the successful breeding of Cupsychus malabaricus birds ex-situ in Kuningan local captivity and to determine the distribution of captive breeding sites in Kuningan Regency. This research was conducted from September to December, and the object he observed was a pair of Cupsychus malabaricus who had entered adulthood.The data co;;ection methode is done by using the census methode yo each captivity. The results of this study were tested using SPSS software with multiple linear regression methods with a confidence value of 95% so from the seven factors, namely male age,famale age, temperature, humidity, feed, cage size, and noise do not affect the factor of hatching eggs. The distribution of the Cupsychus malabaricus breeding in Kuningan Regency is with a total of 30 breeders, the breeders are spread across 25 vilages and 13 districtsTujuan penelitian ini adalah untuk mengetahui faktor penentu keberhasilan penangkaran burung Cuppsychus malabaricus ex-situ di penangkaran lokal Kuningan dan mengetahui sebaran tempat penangkaran di Kabupaten Kuningan. Penelitian ini dilaksanakan pada bulan September sampai dengan bulan Desember, dan objek yang diamati adalah sepasang Cuppsychus malabaricus yang telah memasuki usia dewasa. Metode pengumpulan data dilakukan dengan menggunakan metode sensus pada setiap penakaran. Hasil penelitian ini diuji menggunakan software SPSS dengan metode regresi linier berganda dengan nilai keyakinan 95% sehingga dari ketujuh faktor yaitu umur jantan, umur betina, suhu, kelembaban, pakan, ukuran kandang, dan gangguan tidak berpengaruh terhadap faktor penetasan telur. Sebaran bibit Cuppsychus malabaricus di Kabupaten Kuningan berjumlah 30 orang, peternak tersebar di 25 desa dan 13 kecamatan.
INVENTARISASI DAN IDENTIFIKASI INDUSTRI PRIMER KAYU RAKYAT DI KABUPATEN MAJALENGKA PRIVINSI JAWA BARAT
Authors: Ismail Agus Yadi , Elis Yovi Mustikasari , Adhya Ilham
Published: March 2024

Hutan Rakyat Menjadi alternatif dalam pemasok bahan baku perindustrian. Industri Kayu rakyat memegang peranan yang penting dalam hal menyerap kayu yang dihasilkan oleh petani hutan rakyat. Penelitian ini bertujuan untuk mengetahui potensi Industri primer kayu rakyat, mendapatkan data dan informasi, serta mengetahui sebaran industri primer kayu hutan rakyat di Kabupaten Majalengka. Metode yang digunakan yaitu  metode survey dan wawancara di analisis secara analisis deskriptif dan kualitatif. Dari hasil penelitian terdapat 68 industri penggergajian (sawmill) yang tersebar merata hampir diseluruh kecamatan dari 26 kecamatan hanya satu kecamatan yang tidak terdapat industri penggergajian yaitu Kecamatan Panyingkiran. Jenis kayu yang digunakan yaitu jenis kayu Jati, Mahoni, Sengon, Suren, Afrika, Pinus, Akasia, Puspa, Nangka, Mangga, Campuran (Salam,Tisuk, Randu, Lamtoro, Waru dan Gempol).  Jenis kayu dengan jumlah produksi tertinggi setiap bualannya yaitu Jenis kayu sengon (Paraserianthes falcaria) 2.713 M3,  kayu Mahoni (Swietenia macrophylla) 2.652 M3 Jati (Tectona grandis),  1.352 M3 Afrika (Maesopsis eminii),  916 M3 Mangga (Mangifera indica), 338 M3 dan hasil produk olahan kayu log menjadi produk setengah jadi dengan jumlah semuanya sebesar 4.488.6 M3, menghasilkan papan sebanyak 1.730 M3, kusen 1.134 M3, kaso 669.2 M3, reng 165.5 M3, palet 789.8 M3. Sehingga Pemerintah Kabupaten Majalengka harus mempertahankan jumlah hutan rakyat yang ada, agar ketersedian  bahan baku kayu untuk proses produksi  tetap terpenuhi dan Perlu adanya penelitian lebih lanjut terkait dengan potensi ketersediaan bahan baku kebutuhan industri penggergajian (Sawmill).Kata kunci :Industri Primer, Penggergajian, Sawmill, Hutan Rakyat, Log.
SEBARAN JENIS DAN HARGA INDUSTRI PENGOLAHAN KAYU SETENGAH JADI DI KABUPATEN MAJALENGKA
Authors: Nasihin Iing , Ismail Agus Yadi , Adpan Randi
Published: March 2024

Penelitian ini bertujuan untuk mengidentifikasi dan inventarisasi industri kayu setengah jadi, memetakan daerah sebaran industri pengolahan kayu setengah jadi , mengetahui Sumber bahan baku, jenis kayu dan kapasitas setiap produk industri profil industri pengolahan kayu setengah jadi. Penelitian dilakukan melalui metode survey dimana waktu penelitian ini dilaksanakan adalah 4 bulan pada bulan April sampai Juni 2015 di lakukan di industri sekunder pengrajin kayu di Kabupaten Majalengka. Data yang diperoleh selanjutnya dianalisis dengan menggunakan metode kualitatif.Berdasarkan hasil penelitian diperoleh informasi bahwa jenis kayu yang digunakan didominasi oleh jenis kayu jati, mahoni, jenis kayu tersebut digunakan untuk bahan setengah jadi berupa kusen, pintu, jendela, lemari, bupet dan kursi.Kata Kunci: Identifikasi, inventarisasi, industri kayu
PERANCANGAN SCREW CONVEYOR VERTIKAL DENGAN KAPASITAS 4000 KG/JAM UNTUK TRANSFER GABAH KERING PADA MESIN PENGGILING PADI
Authors: Purnama Harun Giovanni
Published: March 2024

Penelitian ini bertujuan untuk menghasilkan gambar rancangan pemilihan bahan mesin screw conveyor vertikal yang berkapasitas 4000 kg/jam untuk transfer gabah kering pada mesin penggilingan padi. Rancangan mesin conveyor ini memiliki tinggi 3 meter, pada rangka dibuatdalam posisi vertikal untuk mengangkut gabah kering ke hopper mesin penggilingan dan menghemat tempat. Mesin screw conveyor vertikal ini mempunyai komponen penunjang yaitu, motor listrik, poros, drum, hopper dan screw sebagai pendorong gabah kering. Mesin screw conveyor vertikal ini memiliki spesifikasi daya motor listrik sebesar 1 HP yang memiliki tegangan sebesar 380 V / 3 phase, dengan putaran motor sebesar 1000 rpm, diameter poros sebesar 15 cm yang memiliki tegangan dengan kekuatan bahan nya sebesar 12.409  untuk material poros yang digunakan S30Cyang mempunyai kekuatan tarik sebesar 48 , diameter screw sebesar 80 cm dan jarak pitch screw sebesar 44 cm. Pada rancangan ini mesin penggerak menggunakan motor listrik 3 phase.Abstrak memuat latar belakang singkat penelitian, masalah yang akan diselesaikan, pendekatan yang digunakan dam solusi atau hasil penelitian.
RANCANG BANGUN MESIN GERINDA PENGUBAH SUDUT CAMSHAFT (NOKEN AS) KHUSUS MOTOR 4 TAK
Authors: Maulani Irna sari
Published: March 2024

Tujuan tugas akhir ini adalah membangun mesin modifikasi camshaft. Mesin ini digunakan untukmemodifikasi camshaft standar menjadi camshaft racing yang berkapasitas 100cc-250cc. Mesin inimampu menghasilkan 1 camshaft racing/jam. Proses perancangan mesin dilakukan dengan tahapanyaitu menganalisis kebutuhan, mendefinisikan proyek dan daftar persyaratan, menjabarkanperancangan dan pembuatan konsep produk, kemudian merancang produk, dan terakhirmendokumentasikan produk dalam bentuk gambar desain mesin. Tenaga penggerak mesindirencanakan menggunakan motor listrik yang disesuaikan dengan kemampuan daya listrik untukbengkel kecil sampai menengah yang diperkirakan rata-rata berkisar antara 900 sampai 1300 watt.Hasil tugas akhir ini menghasilkan desain dan gambar kerja produk mesin modifikasi camshaftmeliputi gambar poros, gambar dudukan camshaft dan dudukan puli, gambar rangka mesin dan  gambar sistem transmisi. Sumber penggerak mesin adalah motor listrik AC 1 HP (±750 watt). Mesinmodifikasi camshaft yang dihasilkan memiliki kontruksi yang kuat dan ergonomis berdimensipanjang x lebar x tinggi yaitu 500x500x1350 mm dengan rangka baja profil L 40x40x3 mm. Sistemtransmisi menggunakan komponen V-belt, dan puli 3” dan 6”. Komponen pada sistem pengamplasanmenggunakan poros berbahan St 37, dudukan camshaft dan dudukan puli menggunakan bahan St 34,meja mesin menggunakan kayu. Taksiran harga pokok produk mesin yang ditawarkan adalah Rp.3.760.000,-.
Angiokeratoma Corporis Diffusum in the Absence of Known Metabolic Disease and Systemic Features
Authors: Seck Sokhna , Bullock Taylor A. , Khetarpal Shilpi
Published: March 2024

Angiokeratomas are benign capillary ectasias in the superficial dermis. Angiokeratoma corporis diffusum (ACD) is a clinical variant typically associated with an enzyme deficiency in the metabolism of glycoproteins, most notably Fabry disease. ACD has also been found to occur in a benign form with the absence of metabolic disease and lack of systemic features. We present the case of ACD in a 20-year-old male with normal enzyme function and in the absence of any detectable metabolic disorders.
Deucravacitinib in Plaque Psoriasis: 3-year Safety and Efficacy Results from the Phase 3 POETYK PSO-1 and PSO-2 Trials
Authors: Armstrong April W. , Lebwohl Mark , Warren Richard B. , Sofen Howard , Imafuku Shinichi , Ohtsuki Mamitaro , Spelman Lynda , Passeron Thierry , Papp Kim A. , Kisa Renata M. , Berger Victoria , Vritzali Eleni , Hoyt Kim , Colombo Matthew J. , Banerjee Subhashis , Strober Bruce , Thaçi Diamant , Blauvelt Andrew
Published: March 2024

Introduction: Deucravacitinib, an oral, selective, allosteric TYK2 inhibitor, is approved in the US, EU, and other countries for treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy. Deucravacitinib was superior to placebo and apremilast in the POETYK PSO-1 (NCT03624127) and PSO-2 (NCT03611751) parent trials in moderate to severe plaque psoriasis. The POETYK long-term extension (LTE; NCT04036435) trial enrolled patients completing PSO-1/PSO-2. We report deucravacitinib safety and efficacy for up to 3 years (Week 148; through cutoff 6/15/2022).

Methods: PSO-1/PSO-2 randomized patients 1:2:1 to oral placebo, deucravacitinib 6 mg QD, or apremilast 30 mg twice daily. At Week 52, patients enrolled in the LTE received open-label deucravacitinib 6 mg QD. Safety was evaluated in patients receiving ≥1 deucravacitinib dose using exposure-adjusted incidence rate per 100 person-years (EAIR/PY). Efficacy outcomes (PASI 75/90; sPGA 0/1) were analyzed using modified nonresponder imputation (mNRI) in patients receiving continuous deucravacitinib from Day 1 of the parent trial and treated in the LTE.

Results: Of 1519 patients who received ≥1 deucravacitinib dose (3294.3 PY cumulative exposure), 513 received continuous deucravacitinib from Day 1 in PSO-1/PSO-2 and were treated in the LTE. EAIRs/100 PY were comparable, or decreased, between the 2-year and 3-year cumulative periods, respectively, for AEs (154.4, 144.8), serious AEs (6.1, 5.5), discontinuations due to AEs (2.8, 2.4), herpes zoster (0.7, 0.6), malignancies (0.9, 0.9), major adverse cardiovascular events (0.4, 0.3), venous thromboembolism (0.1, 0.1), and deaths (0.4, 0.3). Response rates were maintained at Week 148 by mNRI (PASI 75, 73.2%; PASI 90, 48.1%; sPGA 0/1, 54.1%).

Conclusion: Deucravacitinib maintained a consistent safety profile and durable efficacy for up to 3 years.
Effect of High-Dose Subcutaneous Spesolimab on Skin Manifestations: Results from the Pivotal Effisayil 2 Trial of Flare Prevention in Generalized Pustular Psoriasis
Authors: Strober Bruce , Augustin Matthias , Tada Yayoi , Garg Amit , Jullien Denis , Gottlieb Alice , Gudjonsson Johann , Hu Na , Hofmann Patrick , Thoma Christian , Marzano Angelo
Published: March 2024

Introduction & Objectives: Generalized pustular psoriasis (GPP) is a chronic, rare and potentially life-threatening skin disease, characterized by flares of sterile pustules. Spesolimab, an anti-interleukin-36 receptor monoclonal antibody, is an effective and approved treatment for GPP flares in adults. Effisayil 2 (NCT04399837) was a pivotal, randomized controlled trial that evaluated the efficacy and safety of subcutaneous spesolimab in preventing GPP flares. Here, we report the effect of high-dose spesolimab versus placebo on GPP lesions.

Materials & Methods: Eligible patients with a history of GPP were randomized (1:1:1:1) to receive one of three subcutaneous spesolimab regimens or placebo for 48 weeks. High-dose spesolimab regimen was loading dose 600 mg, followed by maintenance dose 300 mg every 4 weeks. GPP Physician Global Assessment (GPPGA) subscores for erythema, pustules and scaling/crusting, and total score were compared between high-dose spesolimab and placebo groups at baseline and over the treatment period (scale: 0, clear to 4, severe).

Results: Proportion of patients with baseline score of 0 for each GPPGA subscore and total score was generally similar between treatment groups, except erythema; (high-dose spesolimab [n=30] vs placebo [n=31]: erythema, 13.3% vs 22.6%; pustules, 66.7% vs 67.7%; scaling/crusting, 23.3% vs 22.6%; total score, 10.0% vs 12.9%). By Week 4, proportion of patients with scores of 0 increased with high-dose spesolimab versus placebo, (erythema, 33.3% vs 19.4%; pustules, 80.0% vs 41.9%; scaling/crusting, 30.0% vs 19.4%; total score, 26.7% vs 16.1%), and high-dose spesolimab group had fewer flares (10.0% vs 35.5%). This trend was maintained at Week 24 (erythema, 36.7% vs 22.6%; pustules, 63.3% vs 45.2%; scaling/crusting, 36.7% vs 19.4%; total score, 33.3% vs 19.4%) and Week 48 (erythema, 36.7% vs 22.6%; pustules, 66.7% vs 45.2%; scaling/crusting, 43.3% vs 25.8%; total score, 36.7% vs 22.6%). There were no new flares after Week 4 in high-dose spesolimab group; however, flares increased with placebo (45.2% at Week 24; 51.6% at Week 48).

Conclusion: Versus placebo, high-dose subcutaneous spesolimab resulted in a greater proportion of patients maintaining GPPGA scores of 0, a lower proportion having flares at Week 4, and no new flares after Week 4. This was sustained at Weeks 24 and 48.
Continuous Tralokinumab Treatment over 4 Years in Adults with Moderate-to-Severe Atopic Dermatitis Provides Long-Term Disease Control
Authors: Blauvelt Andrew , Langley Richard G. , Peris Ketty , Silvestre Juan Francisco , Katoh Norito , Tauber Marie , Pinter Andreas , Ameen Mahreen , Gooderham Melinda , Øland Christian Bjerregård , Tindberg Ann-Marie , Gjerum Le , Reich Kristian
Published: March 2024

Introduction: Tralokinumab, a monoclonal antibody that specifically neutralizes interleukin-13, is approved for the treatment of moderate-to-severe AD in multiple countries. Clinical trials of up to 52-week duration showed tralokinumab was effective and well-tolerated as monotherapy and in combination with TCS. ECZTEND (NCT03587805) is an ongoing open-label, 5-yr extension trial investigating the long-term safety and efficacy of tralokinumab ± optional TCS. To assess the efficacy of long-term tralokinumab treatment, we conducted a post hoc interim subgroup analysis restricted to the largest, most homogenous patient population, with the longest treatment duration.

Methods: Adult patients with moderate-to-severe AD who were continuously treated with tralokinumab ± optional TCS for 52 weeks in the phase 3 parents trials (PTs) ECZTRA 1 (NCT03131648) or ECZTRA 2 (NCT03160885) and for up to 152 weeks in ECZTEND as of data cutoff 04/30/2022 were included. Endpoints included proportion of patients achieving IGA 0/1, EASI-75 or EASI-90 relative to PT baseline, EASI ≤7, worst weekly pruritus (itch) NRS ≤4, and DLQI ≤5. Results are presented using observed data (AO). Sensitivity analyses on patients who completed Week152 in ECZTEND (or who withdrew, but were enrolled in the study ≥152 weeks prior to cutoff) were performed using mNRI with discontinuations due to AEs or lack of efficacy imputed as non-responders and a 2-step MI for other missing data.

Results: 347 patients with mean age (SD) of 42.2 (14.5) years and mean EASI (SD) of 30.8 (13.7) at PT baseline were included. After 4 years of total tralokinumab treatment (at Week 152 in ECZTEND), IGA 0/1 [% (n/N)] was observed in 52.6% (92/175) of patients. EASI-75 {% (n/N) [95% CI]} was achieved in 84.5% (147/174) [78.4, 89.1] of patients AO, and 73.4% (254.8/347) [68.6, 78.3] using mNRI. EASI-90 was achieved in 64.4% (112/174) [57.0, 71.1] of patients AO, and 53.4% (185.2/347) [47.8, 59.0] using mNRI. EASI ≤7 was observed in 84.5% (147/174), itch NRS ≤4 in 68.0% (119/175), and DLQI ≤5 in 79.0% (128/162) of patients. The safety profile was favorable and consistent with earlier analyses, with no new safety signals arising with continued tralokinumab use.

Conclusions: Continuous use of tralokinumab ± optional TCS provided long-term disease control over 4 years in adult patients with moderate-to-severe AD.
Progressive and Sustained Disease Control in Patients with Atopic Dermatitis (AD) Aged 12–17 Years Treated with Tralokinumab for 52 Weeks
Authors: Wollenberg Andreas , Cork Michael , Hong Chih-Ho , Kurbasic Azra , Vacko Emilia , Paller Amy
Published: March 2024

Introduction: The ECZTRA 6 trial showed that tralokinumab 300mg provided progressive and sustained efficacy in adolescent patients with moderate-to-severe AD, and was well tolerated with a reassuring long-term safety profile over 52 weeks.
Objective: To evaluate EASI response and PROs in adolescents from ECZTRA 6 treated with tralokinumab 300mg for the full 52-week treatment period.
Methods: Patients were randomized to tralokinumab 300mg Q2W (n=97) or placebo (n=94) for 16 weeks. At Week 16, patients initiated on tralokinumab and achieving primary endpoints (IGA 0/1 and/or EASI-75) without rescue were re-randomized to tralokinumab 300mg Q2/4W monotherapy for 36 additional weeks; other patients were switched to open-label tralokinumab 300mg Q2W plus optional topical corticosteroids. Post-hoc analyses were conducted by pooling Week 16–52 data for all patients initially randomized to tralokinumab 300mg Q2W.
 Results: Greater proportions of tralokinumab- vs placebo-treated patients achieved primary endpoints at Week 16; progressive improvement was seen through Week 52. In addition, pruritus NRS score was improved for a greater proportion of tralokinumab- vs placebo-treated patients from baseline to Week 16, with further improvement up to Week 52. Progressive improvements over time were also observed for proportions of patients with reductions of pruritus NRS ≥4, POEM ≥4, and CDLQI ≥6, from baseline.  The safety profile was consistent with prolonged treatment following Week 16.
 Conclusions: At Week 16, tralokinumab 300mg Q2W improved EASI and PROs in adolescents with AD, with progressive and sustained improvement seen up to Week 52.
Efficacy Following Discontinuation of Sonidegib Treatment in Patients With Locally Advanced Basal Cell Carcinoma: Results From the BOLT 42-Month Analysis
Authors: Migden Michael , Kheterpal Meenal , Moody Brent , Patel Kunal , Lionnet Leonard , Sivam Sakthivel , Conti Joe , Squittieri Nicholas , Farberg Aaron
Published: March 2024

Introduction: Sonidegib, a Hedgehog (HH) pathway inhibitor, is approved for the treatment of locally advanced basal cell carcinoma (laBCC) not amenable to curative surgery or radiation. The pivotal 42-month BOLT (NCT01327053) study demonstrated sustained efficacy and manageable safety of sonidegib. Prior analyses at 18 months demonstrated clinical benefit persisting beyond sonidegib discontinuation. Pharmacokinetic modeling suggests HH pathway inhibition can be maintained following discontinuation. This analysis presents the efficacy of sonidegib 200 mg daily in patients with laBCC who discontinued treatment without disease progression (PD) at 42 months (end of study).

Methods: BOLT was a randomized, double-blind, placebo-controlled, Phase 2 study. Objective response rates (ORRs; complete response + partial response), duration of response (DOR), and progression-free survival (PFS) were assessed by central and investigator review per modified response evaluation criteria in solid tumors (mRECIST). Adverse events (AEs) were also assessed.

Results: Of the 66 patients with laBCC randomized to sonidegib 200 mg daily, 37 discontinued treatment without PD. The ORRs for these patients per central (57% [n = 20]) and investigator (73% [n = 27]) review were similar to the overall patient population (61% [n = 40] and 71% [n = 47] per central and investigator review, respectively). For patients who discontinued treatment, the median (95% confidence interval [CI]) DOR per central and investigator review was not estimable (NE) and 20.2 months (12.0, NE), respectively. The median PFS (95% CI) per central and investigator review was NE and 22.0 months (16.6, NE), respectively. Most AEs were Grades 1/2 in severity.

Conclusion: In this 42-month analysis among patients with laBCC who received sonidegib 200 mg daily, clinical benefit was observed beyond treatment discontinuation during this study.
Efficacy and Safety of Fixed-Dose Triple-Combination Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel for Moderate-to-Severe Acne Vulgaris in Children and Adolescents
Authors: Eichenfield Lawrence , Hebert Adelaide , Harper Julie , Baldwin Hilary , Bhatia Neal , Stein Gold Linda , Kircik Leon , Graber Emmy , Tanghetti Emil , Alexis Andrew , Del Rosso James
Published: March 2024

Background: Topical clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% (CAB) gel is the first fixed-dose triple-combination formulation approved for acne vulgaris and is indicated for use in patients aged 12 years and older. As topical acne treatment in pediatric patients may be complicated by tolerability issues and/or a perceived lack of efficacy, the objective of this post hoc analysis was to investigate the efficacy and safety of CAB in children and adolescents.

Methods: Data were pooled from two phase 3 double-blind, randomized, 12-week studies (NCT04214639; NCT04214652). Eligible participants ≥9 years of age with moderate-to-severe acne were randomized (2:1) to once-daily CAB or vehicle gel. This analysis evaluated adolescents aged 12-17 years (CAB: n=123; vehicle: n=50). Endpoints included ≥2-grade reduction from baseline in Evaluator’s Global Severity Score and clear/almost clear skin (treatment success), least-squares mean percent change from baseline in inflammatory/noninflammatory lesions, and treatment-emergent adverse events (TEAEs). Descriptive efficacy and safety data for five children aged 10-11 years enrolled in the study are also summarized (CAB: n=3; vehicle: n=2).

Results: At week 12, 51.5% of CAB–treated participants aged ≥12 years achieved treatment success vs 24.9% with vehicle gel (P<0.01). CAB treatment resulted in significant reductions of >70% in inflammatory and noninflammatory lesion counts in adolescents (78.3% and 73.7%, respectively) vs vehicle (50.5% and 42.9%; P<0.001, both). Most TEAEs were of mild-to-moderate severity, and the most common (>3% in any treatment) treatment-related TEAE was application site pain. Less than 2.5% of participants withdrew due to AEs. For the 5 children aged <12 years, all 3 treated with CAB achieved treatment success, with reductions in inflammatory/noninflammatory lesions ranging from 76%-100%; neither vehicle-treated participant achieved treatment success. Only one CAB–treated younger participant experienced TEAEs (application site pain/dryness, and erythema [all mild/moderate]) and none discontinued the study.

Conclusions: In two pooled phase 3 studies, once-daily CAB gel—the first approved fixed-dose, triple-combination topical formulation for acne vulgaris—was well tolerated and efficacious in pediatric participants with moderate-to-severe acne, with over half achieving treatment success at week 12.

Funding: Ortho Dermatologics
Long-Term Efficacy of Ritlecitinib up to Month 24 From the ALLEGRO Phase 2b/3 and Long-Term Phase 3 Clinical Studies in Alopecia Areata
Authors: Piliang Melissa , Soung Jennifer , King Brett , Shapiro Jerry , Rudnicka Lidia , Farrant Paul , Magnolo Nina , Piraccini Bianca , Luo Xin , Woodworth Deborah , Schaefer Gregor , Lejeune Alexandre , Wolk Robert
Published: March 2024

Introduction: Ritlecitinib demonstrated efficacy and safety to Week 48 in patients aged ≥12 years with alopecia areata (AA) in ALLEGRO-2b/3 (NCT03732807). ALLEGRO-LT (NCT04006457) is an ongoing, phase 3, open-label study investigating the long-term safety and efficacy of ritlecitinib in AA. We report updated interim efficacy results of ritlecitinib up to Month 24 from ALLEGRO-2b/3 and ALLEGRO-LT.

Methods: Patients aged ≥12 years with AA and ≥50% scalp hair loss who rolled-over to ALLEGRO-LT from ALLEGRO-2b/3 were included. Data are reported for patients who received: 1) daily ritlecitinib 50-mg with a 4-week 200-mg daily loading dose (“200/50-mg”); 2) daily ritlecitinib 50-mg with no loading dose (“50-mg”). Outcomes include the proportions of patients with response (based on Severity of Alopecia Tool [SALT] score ≤20, SALT ≤10, and Patients’ Global Impression of Change [PGI-C] score of “moderately improved” or “greatly improved”) through Month 24, and the proportions of patients sustaining SALT ≤20 response from Month 12 through Month 24. Observed and imputed (modified last observation carried forward [mLOCF]) data, to account for missing values, are reported (data cutoff: December 9, 2022).

Results: The 200/50-mg and 50-mg groups included 194 and 191 patients; 127 (65.5%) and 111 (58.1%) were ongoing at the data cutoff. SALT ≤20 response rates in the 200/50-mg and 50-mg groups increased from Month 12 (45.9% and 45.1% [observed]; 41.8% and 40.3% [mLOCF]) to Month 24 (63.1% and 60.8% [observed]; 50.8% and 46.1% [mLOCF]). SALT ≤10 response rates increased between Months 12 and 24 for the 200/50-mg group (39.4% to 51.1% [observed]; 35.6% to 40.9% [mLOCF]) and 50-mg group (34.2% to 50.8% [observed]; 30.9% to 37.7% [mLOCF]). Of SALT ≤20 responders at Month 12, 92.8% (200/50-mg) and 79.7% (50-mg) (observed) sustained this response through Month 24. PGI-C response rates were maintained from Month 12 (200/50-mg: 69.4% [observed], 65.3% [mLOCF]; 50-mg: 61.6% [observed], 57.7% [mLOCF]) to Month 24 (200/50-mg: 76.4% [observed], 65.4% [mLOCF]; 50-mg: 70.0% [observed], 56.6% [mLOCF]).

Conclusion: Ritlecitinib 50-mg (with or without a 200-mg loading dose) demonstrated clinically meaningful and sustained clinician- and patient-reported efficacy through Month 24, which supports its long-term use in patients aged ≥12 years with severe AA.
Exploring the efficacy and safety of anti-BCMA chimeric antigen receptor T-cell therapy for multiple myeloma: Systematic review and meta-analysis
Authors: Zhang Jia , Ding Xinhua , Ding Xiaoxiao
Published: March 2024

Objective:

Multiple myeloma (MM) is a bone marrow cancer that profoundly affects plasma cells involved in the immune response. Myeloma cells alter the average production of cells in the bone marrow. Anti-B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T-cell therapy allows genetic modifications of an individual’s T-cells to increase the expression of CARs used to identify and attach BCMA proteins to the malignant cells. Our main objective is to perform a systematic review and meta-analysis to explore the efficacy and safety of anti-BCMA CAR T-cell therapy for MM.

Material and Methods:

We searched five databases, PubMed, CNKI, EMBASE, Cochrane, Web of Science, and CNKI, for studies published on anti-BCMA,CAR-T-cell treatment for MM. Inclusion criteria involved prospective single-arm studies either single or multi-center, in various MM phases and studies that reported anti-BCMA,CAR-T-cell treatment for MM. We excluded non-English publications and conference papers. All statistical analyses were performed in R software and Review Manager 5.4.1.

Results:

Thirteen articles were included in the analysis. We found that the overall response survival complete response increase was statistically significant. Similarly, the reduction in cytokine release syndrome grades 3 and 4 and neurotoxicity after follow-up was statistically significant. However, the reduction in minimal residual disease negativity (MRDN) was not statistically significant.

Conclusion:

Using anti-BCMA CAR T-cell therapy in MM was highly efficacious and safe in lowering the adverse outcomes and improving the survival outcomes, complete response, and overall response.
Correlation of Students’ Listening Comprehension Score With Students’ Learning Styles at Students of English Department at University of Muhammadiyah Gresik
Authors: Hedar Pratama Chico , Anwar Khoirul
Published: March 2024

Listening ability is an important component of language teaching and learning as it tends to improve faster than speaking ability and frequently influences skill development when learning anything new. Meanwhile, in order to accomplish excellent academic outcomes, students need to consider their learning styles and teachers need to consider various students’ learning style. This study aims to investigate the correlation between the listening abilities of learners and their learning styles. The participants were students of English education study program, faculty of teaching and educational sciences, Muhammadiyah University of Gresik, with 48 males and 52 female students participating. This study employed quantitative approaches using a questionnaire to assess students' learning styles, a test to assess students' listening comprehension scores, and an interview as a few sample about students’ perception. The data analyzed used SPSS Pearson's Correlation Coefficients and thematic analysis. The level of probability (p-value) significance (sig.2-tailed) resulted in .003. Since, the p-value (.003) was less than .05, Ha (alternative hypothesis) was accepted and Ho (null hypothesis) was rejected. As a result of the acceptance of the Ha (alternative hypothesis), researchers discovered there is a significant correlation connecting both visual and auditory learning styles and listening comprehension. The impact of this study to help students aware with their learning styles and teachers need to consider efficient learning activities with students’ various learning style.
The Intersection of Gender, Culture, and Metacognitive Reading Strategies in Iranian EFL Education: A Mixed-Methods Analysis in Pursuit of Inclusion and Equity
Authors: Ghadamgahi Mahdi , Ghafournia Narjes
Published: March 2024

In English as a Foreign Language (EFL) education, metacognitive reading strategies (MRS) play a crucial role in learners' reading comprehension. This mixed-methods study investigated MRS among 178 Iranian EFL learners, focusing on gender and sociocultural dimensions. Utilizing an explanatory sequential design, participants—116 females and 62 males—were randomly sampled from two universities in Neyshabur, Iran. For the quantitative phase, a descriptive-correlational design using the Survey of Reading Strategies (SORS) and the TOEFL iBT reading section was employed. Descriptive analysis revealed nuanced differences in the use of MRS among Iranian EFL learners across genders, with an overall higher application by females (M = 3.61) compared to males (M = 3.44). In Support Reading Strategies, females demonstrated a higher application of strategies (M = 3.87) compared to males (M = 3.68). For Problem-Solving Strategies, female learners exhibited more frequent usage (M = 3.72) than their male counterparts (M = 3.46). Additionally, in Global Reading Strategies, there is a slight gender differential, with females showing a higher average score (M = 3.37) as opposed to males (M = 3.26). Independent samples t-tests revealed gender-specific differences in the overall MRS application, particularly in the subcategories of support and problem-solving strategies (p < .05), favoring females. In the qualitative phase, 12 participants were purposively sampled for semi-structured interviews. Thematic analysis identified gender disparities exacerbated particularly by implicit teacher biases and sociocultural factors. These qualitative results corroborated and enriched the quantitative data, especially regarding gender-specific variations in MRS usage.
Didactic learning strategies in higher education: analysis of effectiveness and ways of optimization in Russia
Authors: Зуфарова А.С. , Жданова Т.А.
Published: March 2024

Дидактические стратегии в высшем образовании России испытывают значительные трансформации, обусловленные глобализацией образовательных процессов и интеграцией информационно-коммуникационных технологий. Актуальность исследования обусловлена необходимостью анализа и оптимизации дидактических стратегий для повышения качества обучения и удовлетворения потребностей современного общества. Исследование базируется на анализе данных, полученных из 150 ведущих вузов России, включая университеты федерального и регионального уровней. Применялись качественные и количественные методы анализа, в том числе контент-анализ учебных программ и анкетирование студентов и преподавателей, что позволило собрать данные о применении и эффективности различных дидактических стратегий. Результаты. Анализ показал, что внедрение интерактивных методов обучения, таких как обратная связь в реальном времени, использование кейс-методов и проектного обучения, способствует улучшению понимания материала студентами на 30-40% по сравнению с традиционными методиками. Использование цифровых платформ для совместной работы увеличило уровень вовлеченности студентов на 25%. Однако наблюдается диспропорция в применении инновационных подходов между ведущими университетами и региональными ВУЗами: в первых инновационные методы используются в 70% курсов, в то время как в последних - только в 40%.

Didactic strategies in higher education in Russia are undergoing significant transformations due to the globalization of educational processes and the integration of information and communication technologies. The relevance of the research is due to the need to analyze and optimize didactic strategies to improve the quality of education and meet the needs of modern society. Materials and methods. The study is based on the analysis of data obtained from 150 leading universities in Russia, including universities at the federal and regional levels. Qualitative and quantitative methods of analysis were used, including content analysis of curricula and questionnaires of students and teachers, which allowed us to collect data on the application and effectiveness of various didactic strategies. Results. The analysis showed that the introduction of interactive teaching methods, such as real-time feedback, the use of case methods and project-based learning, improves students' understanding of the material by 30-40% compared to traditional methods. The use of digital collaboration platforms has increased the level of student engagement by 25%. However, there is a disparity in the application of innovative approaches between leading universities and regional universities: in the former, innovative methods are used in 70% of courses, while in the latter - only in 40%.
Development and implementation of multi-agent management models in the educational process of Russian universities to increase the level of adaptation of students
Authors: Мартынова Ю.А.
Published: March 2024

В эпоху глобальной цифровизации и динамичного развития образовательных технологий, вопрос адаптации студентов в высших учебных заведениях приобретает особую актуальность. Рассматриваемый в данном исследовании подход к внедрению мультиагентных моделей управления в образовательный процесс высших учебных заведений Российской Федерации основывается на целях повышения адаптационных способностей студентов к изменяющимся образовательным реалиям. Материалы и методы. Исследование базируется на анализе данных о динамике адаптации студентов в 50 ведущих вузах России за последние 5 лет, сборе и обработке статистических данных, проведении анкетирования среди 2000 студентов и 300 преподавателей, а также на разработке и тестировании мультиагентной модели на базе пилотной программы, внедренной в 10 университетах. Результаты. В ходе исследования было выявлено, что внедрение мультиагентных моделей способствует улучшению адаптационных процессов студентов на 35%. В частности, уровень успешной адаптации студентов первого курса увеличился на 40% по сравнению с традиционными методами обучения. Мультиагентная модель, интегрированная в образовательный процесс, включает в себя индивидуализированные обучающие траектории, алгоритмы машинного обучения для анализа успеваемости и предпочтений студентов, а также модули виртуальной реальности для имитации реальных профессиональных ситуаций.

In the era of global digitalization and the dynamic development of educational technologies, the issue of student adaptation in higher education institutions is becoming particularly relevant. The approach considered in this study to the introduction of multi-agent management models into the educational process of higher educational institutions of the Russian Federation is based on the goals of increasing the adaptive abilities of students to changing educational realities. Materials and methods. The study is based on the analysis of data on the dynamics of student adaptation in 50 leading universities in Russia over the past 5 years, the collection and processing of statistical data, conducting surveys among 2,000 students and 300 teachers, as well as on the development and testing of a multi-agent model based on a pilot program implemented in 10 universities. Results. The study revealed that the introduction of multi-agent models contributes to the improvement of students' adaptation processes by 35%. In particular, the level of successful adaptation of first-year students increased by 40% compared to traditional teaching methods. The multi-agent model integrated into the educational process includes individualized learning trajectories, machine learning algorithms for analyzing student performance and preferences, as well as virtual reality modules to simulate real professional situations.