bluuebunny/crossref_metadata_2025 huggingface dataset:
Does aspirin prescribed to women deemed high risk for preterm pre‐eclampsia at 11–13+6 weeks gestation affect the prevalence of small for gestational age neonates?
Authors: Park Felicity , O’Brien Cecelia , Phung Jason , Emeto Theophilus , Hyett Jon
Published: December 2020

Background

Aspirin has been shown to reduce prevalence of both early‐onset pre‐eclampsia (ePET) and fetal growth restriction (FGR).

Aims

To determine whether aspirin prescribed for risk of ePET reduces the prevalence of small for gestational age (SGA) neonates.

Material and Methods

Two prospective cohorts were consecutively recruited in a large university hospital in Sydney. The Observational cohort (April 2010 to March 2012) validated an algorithm for ePET screening, where risk for ePET was modelled on history, mean arterial pressure, uterine artery pulsatility index and pregnancy‐associated plasma protein A. The Interventional cohort (April 2012 to December 2017) were screened and allocated women at high risk of developing ePET to aspirin 150 mg. The prevalence of preterm and term SGA was compared using regression analysis.

Result

There were 3013 and 8424 women screened in the Observational and Interventional cohorts respectively. Women who screened high risk for ePET were three to four times more likely to give birth to a neonate classified as SGA in the Observational (6.8% vs 1.9%) and Interventional cohorts (6.0% vs 1.8%). In women who screened high risk, there were no statistically significant differences in the prevalence of SGA neonates (6.6% vs 6.0%; adjusted odds ratio 0.84 (0.50–1.42)) in women who received aspirin compared to women who did not.

Conclusions

Women who screen high risk for ePET have an increased chance of delivering an SGA infant. A reduction in the prevalence of SGA neonates when aspirin was prescribed to women who screened high risk for ePET did not reach clinical significance in our cohort.
Perceptions of UK clinicians towards postoperative critical care
Authors: Hashim S. , Wong D. J. N. , Farmer L. , Harris S. K. , Moonesinghe S. R.
Published: December 2020

Postoperative critical care is a finite resource that is recommended for high‐risk patients. Despite national recommendations specifying that such patients should receive postoperative critical care, there is evidence that these recommendations are not universally followed. We performed a national survey aiming to better understand how patients are risk‐stratified in practice; elucidate clinicians’ opinions about how patients should be selected for critical care; and determine factors which affect the actual provision of postoperative critical care. As part of the second Sprint National Anaesthesia Project, epidemiology of critical care after surgery study, we distributed a paper survey to anaesthetists, surgeons and intensivists providing peri‐operative care during a single week in March 2017. We collected data on respondent characteristics, and their opinions of postoperative critical care provision, potential benefits and real‐world challenges. We undertook both quantitative and qualitative analyses to interpret the responses. We received 10,383 survey responses from 237 hospitals across the UK. Consultants used a lower threshold for critical care admission than other career grades, indicating potentially more risk‐averse behaviour. The majority of respondents reported that critical care provision was inadequate, and cited the value of critical care as being predominantly due to higher nurse: patient ratios. Use of objective risk assessment tools was poor, and patients were commonly selected for critical care based on procedure‐specific pathways rather than individualised risk assessment. Challenges were highlighted in the delivery of peri‐operative critical care services, such as an overall lack of capacity, competition for beds with non‐surgical cases and poor flow through the hospital leading to bed ‘blockages’. Critical care is perceived to provide benefit to high‐risk surgical patients, but there is variation in practice about the definition and determination of risk, how patients are referred and how to deal with the lack of critical care resources. Future work should focus on evaluating ‘enhanced care’ units for postoperative patients, how to better implement individualised risk assessment in practice, and how to improve patient flow through hospitals.
Perinatal outcomes of twin pregnancies complicated by late twin‐twin transfusion syndrome: A systematic review and meta‐analysis
Authors: Sileo Filomena Giulia , D’antonio Francesco , Benlioglu Can , Bhide Amar , Khalil Asma
Published: December 2020

Introduction

Untreated twin‐to‐twin transfusion syndrome (TTTS) is associated with a high risk of perinatal mortality and morbidity. Laser surgery is recommended before 26 weeks of gestation. However, the optimal management in case of late TTTS (occurring after 26 weeks of gestation) is yet to be established.

Material and methods

We conducted a systematic review and meta‐analysis to evaluate the outcomes of monochorionic‐diamniotic twin pregnancies complicated by late TTTS according to different management options (expectant, laser therapy, amnioreduction, or delivery). The primary outcome was mortality, including single and double intrauterine, neonatal, and perinatal death. Secondary outcomes were composite morbidity, neuromorbidity, respiratory distress syndrome, admission to neonatal intensive care unit, intact survival (ie, free from neurological complications), and preterm birth before <32 weeks of gestation. Outcomes were reviewed according to the management and reported for the overall population of twins and disease status (ie, donor and recipient separately). Random‐effect meta‐analyses of proportions were used to analyze the data.

Results

Nine studies including 796 twin pregnancies affected by TTTS were included. No randomized controlled trials were available for inclusion. TTTS occurred at ≥26 weeks of gestation in 8.7% (95% CI 6.9%‐10.9%; 67/769) of cases reporting TTTS at all gestations. Intrauterine death occurred in 17.7% (95% CI 4.9%‐36.2%) of pregnancies managed expectantly, 5.3% (95% CI 0.9%‐12.9%) of pregnancies treated with laser, and 0% (95% CI 0%‐9%) after amnioreduction. Neonatal death occurred in 42.5% (95% CI 17.5%‐69.7%) of pregnancies managed expectantly, in 2.8% (95% CI 0.3%‐7.7%) of cases treated with laser, and in 20.2% (95% CI 6%‐40%) after amnioreduction. Only one study (10 cases) reported data on immediate delivery after diagnosis with no perinatal deaths. Perinatal death incidence was 55.7% (95% CI 31.4%‐78.6%) in twin pregnancies managed expectantly, 5.6% (95% CI 0.5%‐15.3%) in those treated with laser, and 20.2% (95% CI 6%‐40%) in those after amnioreduction. Intact survival was reported in 44.4%, 96.4%, and 78% of fetuses managed expectantly, with laser or amnioreduction, respectively.

Conclusions

Evidence regarding perinatal mortality and morbidity in twin pregnancies complicated by late TTTS according to the different managements was of very low quality. Therefore further high‐quality research in this field is needed to elucidate the optimal management of these pregnancies.
Uterine contractions in rodent models and humans
Authors: Malik Manasi , Roh Michelle , England Sarah K.
Published: December 2020

Aberrant uterine contractions can lead to preterm birth and other labour complications and are a significant cause of maternal morbidity and mortality. To investigate the mechanisms underlying dysfunctional uterine contractions, researchers have used experimentally tractable small animal models. However, biological differences between humans and rodents change how researchers select their animal model and interpret their results. Here, we provide a general review of studies of uterine excitation and contractions in mice, rats, guinea pigs, and humans, in an effort to introduce new researchers to the field and help in the design and interpretation of experiments in rodent models.
Institutional bricolage in payment for ecosystem services: Insights from the Sloping Land Conversion Programme in upland communities, Southwest China
Authors: He Jun
Published: December 2020

Global discussion of payment for ecosystem services (PES) has moved beyond the simple notion of effecting environmental and livelihood improvement for participants. Changes in the local governance following the introduction of PES have become a focus as it may affect the local incentive for sustainable natural resource management. Although there has been increasing attention on the interplay between different institutions in shaping PES outcomes, the institutional outcomes resulting from these interactions and the understandings of local institutional dynamics are limited. Drawing on in‐depth case studies from Southwest China, this research uses an institutional bricolage framework to examine how pre‐existing and informal local institutions interacted with a newly introduced and formal PES programme – the Chinese Sloping Land Conversion Programme. It reveals that institutional bricolage processes can lead to positive ecological and socioeconomic outcomes when hybrid institutions were built to fit the local socio‐ecological contexts. The policy implication from this research calls for decentralisation reforms and provision of institutional flexibility. This would allow bricolage processes to foster adaptive governance in the implementation of PES programmes.
Implicit black‐weapon associations weakened over time in increasingly multiethnic metropolitan areas
Authors: Somo Angela , Sadler Melody , Devos Thierry
Published: December 2020

A repeated cross‐sectional design was used to examine whether temporal changes in implicit Black‐weapon associations were dependent on the changing ethnic diversity of metropolitan areas over the course of a decade (2009–2018). Data on implicit Black‐weapon associations were obtained from Project Implicit. Three indicators of ethnic diversity were calculated using American Community Survey data. Minority representation referred to the proportion of African American residents. Variety was operationalized as the degree to which six ethnic groups each accounted for an equal proportion of the population. Integration assessed the degree to which ethnic groups were evenly distributed across census tracts making up the metropolitan area. Multilevel model analyses (N = 345,647 participants, nested within 185 metropolitan areas) revealed that implicit Black‐weapon associations weakened over time, and to a larger degree in metropolitan areas characterized by steeper increases in variety. This longitudinal relationship is consistent with the notion that, as metropolitan areas become more multiethnic, implicit associations between crime, danger, or violence and Black Americans decline.
Development of the Timed Re‐Insemination (TRI‐synch) program re‐inseminating 24 days after the initial service in dairy cows
Authors: Aizu Marina , Ido‐Matsumoto Haruka , Wada Natsumi , Kumazaki Hiromasa , Kubo Tomoaki , Kanazawa Tomomi , Izaike Yoshiaki , Takahashi Toru
Published: December 2020

For the timed re‐insemination at the minimal interbreeding interval, cows were treated with a progesterone (P4)‐releasing intravaginal device from Days 13–15 to 21 post‐insemination (Day 0 = estrus), followed by plasma P4 assay on Day 23 and then subjected to the Experiments 1 and 2. In Experiment 1, of 18 cows, 6 cows were determined as luteolysis with low (<1 ng/ml) plasma P4 concentrations on Day 23 and ovulated on Days 24 (3 cows), 25 (1 cow), and 26 (1 cow) except a cow affected by ovarian quiescence. In Experiment 2, all cows were treated with GnRH on Day 23. Cows with low (<1 ng/ml) plasma P4 concentrations on Day 23 were diagnosed as non‐pregnant and subjected to the re‐insemination in the morning of Day 24 irrespective of estrous signs. Of 36 cows, 15 cows were diagnosed as being non‐pregnant on Day 23. Fourteen cows of the non‐pregnant animals were re‐inseminated in the morning of Day 24 irrespective of estrous signs and the pregnancy rate of re‐insemination was 36%. The conception rates of initial and re‐inseminations were 50% (18/36) and 36% (5/14), respectively. The overall pregnancy rate by adding the rates of initial and re‐inseminations was 64% (23/36).
Embryo production by intracytoplasmic injection of sperm retrieved from neonatal testicular tissue of Agu pigs after cryopreservation and grafting into nude mice
Authors: Kaneko Hiroyuki , Kikuchi Kazuhiro , Men Nguyen Thi , Dang‐Nguyen Thanh Quang , Oyadomari Motoharu , Touma Shihei , Suzuki Naoto , Katagiri Yoshito
Published: December 2020

The Agu is the only indigenous pig breed in Japan but its population is very small. In order to estimate the efficacy of testicular xenografting for the conservation of Agu pigs, we investigated whether neonatal testicular fragments would acquire the capacity to produce sperm after they had been cryopreserved and grafted into nude mice. Although on day 180 (day 0 = xenografting), grafts showed a low proportion of seminiferous tubule cross‐sections containing sperm (0.1 ± 0.1%, mean ± SEM for four mice), the proportion reached 36.9 ± 16.7% (n = 4 mice) by day 240. When single sperm obtained on day 240 was injected into individual porcine oocytes, 28.2% of the oocytes were found to contain one male and one female pronuclei with the second polar body. Moreover, the blastocyst formation rate after injection of the xenogeneic sperm was 28.4%, whereas that in the absence of sperm injection (attributable to parthenogenesis) was 13.3%. These findings suggest that more than half of the blastocysts resulted from fertilization. Thus, testicular xenografting could assist the conservation of Agu pigs by salvaging germ cells present in neonatal testes even after cryopreservation.
Genetic relationships of calving difficulty with birth measurements and carcass traits in Japanese Black cattle
Authors: Hosono Masahiko , Oyama Hidemi , Inoue Keiichi
Published: December 2020

The objectives of this study were to compare the genetic parameters for calving difficulty (CD), which were treated as both a calf trait (CD_calf) and as a dam trait (CD_dam), and to clarify genetic relationships of these CDs with body size traits of calves at birth and carcass traits. In total, the CD records and calf body measurements of 2,258 Japanese Black cattle heifers were used in this study, in addition to the carcass records of 4,300 feedlot steers and heifers. Direct heritability of CD_calf (0.44) was higher than maternal heritability of CD_calf (0.30), as well as CD_dam heritability (0.25). Direct genetic correlations between CD_calf and calf body size were moderate to strongly positive (0.64 to 0.81). The correlations between EBVs of CDs and carcass weight were also positive (0.30 to 0.64). These positive relationships showed that genetically improving CD (reducing dystocia) could produce smaller calves and carcasses. In contrast, the correlations between CDs and beef marbling score were weak, suggesting that improving CD would not influence meat quality traits. Fitting an animal model to CD_calf could be more preferred to fitting the model to CD_dam, because the former could separate the genetic effects of dams and calves.
Convergent technologies in science and innovations in Kazakhstan
Authors: Issayeva Gulmira Kuzdeualiyevna , Zhussipova Elmira Yelbergenovna , Kuralbayeva Alma Shorayevna , Beisenova Madina Unaibekovna , Maulenkulova Gulbana Erzhigitovna , Zhakipbekova Dinara Saparovna
Published: December 2020

As soon as the economy of Kazakhstan is highly resource‐oriented despite numerous efforts to change the structure of the national economy, constant assessment of the scientific and innovation sphere of the country is actual and important. By way of qualitative, quantitative, comparative, and descriptive analysis 13 indicators related to science and innovations were investigated to define the level of scientific and innovative development in Kazakhstan. Science and innovation in Kazakhstan are under‐financed and state‐based financing of innovative activities seems to be ineffective, and the innovations are still unprofitable. The scientific human capital is affected by “brain drain,” when best graduates go into business or leave the country to build careers in better financial conditions. Eight indicators are found to be universal and comparable for various countries, and can be applied with the purpose of defining the level of scientific and innovative development of a country or countries. The results of the study can be applied by governmental officials for developing policies related to science and innovations. The methods, set of indicators, and findings of the study can be used by other researchers for investigating and comparing the level(s) of scientific and innovative development in other country or countries.
A possible increased risk of metamizole‐associated neutropenia among COVID‐19 patients
Authors: Lerman Tsahi T. , Sagi Moshe , Shafir Yair , Sheena Liron , Cohen Eytan , Goldberg Elad , Krause Ilan
Published: December 2020

Metamizole is commonly used as analgesic and antipyretic drug. The use of metamizole is prohibited in several countries due to its rare side effect of neutropenia and even agranulocytosis. Among the many symptoms of COVID‐19, fever and diffuse pain predominant and therefore it can be assumed that metamizole may be widely used in the current epidemic period. So far, there have been no reports on the safety of metamizole in COVID‐19 patients. We describe a series of 3 patients who developed severe neutropenia under metamizole treatment, raising a concern of a possible increased risk of this side effect among COVID‐19 patients.
Evaluation of drug interaction potential of zanubrutinib with cocktail probes representative of CYP3A4, CYP2C9, CYP2C19, P‐gp and BCRP
Authors: Ou Ying C. , Tang Zhiyu , Novotny William , Tawashi Manal , Li Ta‐Kai , Coleman Hugh A. , Sahasranaman Srikumar
Published: December 2020

Aim

This study aims to assess the potential effects of zanubrutinib on the activity of cytochrome P450 (CYP) enzymes and drug transporter proteins using a cocktail probe approach.

Methods

Patients received single oral doses of probe drugs alone and after at least 8 days of treatment with zanubrutinib 160 mg twice daily in a single‐sequence study in 18 healthy male volunteers. Simultaneous doses of 10 mg warfarin (CYP2C9) and 2 mg midazolam (CYP3A) were administered on Day 1 and Day 14, 0.25 mg digoxin (P‐glycoprotein [P‐gp]) and 10 mg rosuvastatin (breast cancer resistance protein [BCRP]) on Day 3 and Day 16, and 20 mg omeprazole (CYP2C19) on Day 5 and Day 18. Pharmacokinetic (PK) parameters were estimated from samples obtained up to 12 h post dose for zanubrutinib; 24 h for digoxin, omeprazole and midazolam; 48 h for rosuvastatin; and 144 h for warfarin.

Results

The ratios (%) of geometric least squares means (90% confidence intervals) for the area under the concentration–time curve from time zero to the last quantifiable concentration in the presence/absence of zanubrutinib were 99.80% (97.41–102.2%) for S‐warfarin; 52.52% (48.49–56.88%) for midazolam; 111.3% (103.8–119.3%) for digoxin; 89.45% (78.73–101.6%) for rosuvastatin; and 63.52% (57.40–70.30%) for omeprazole. Similar effects were observed for maximum plasma concentrations.

Conclusions

Zanubrutinib 320 mg total daily dose had minimal or no effect on the activity of CYP2C9, BCRP and P‐gp, but decreased the systemic exposure of CYP3A and CYP2C19 substrates (mean reduction <50%).
Glucocorticoid treatment in patients with newly diagnosed immune thrombocytopenia switches CD14++CD16+ intermediate monocytes from a pro‐inflammatory to an anti‐inflammatory phenotype
Authors: Williams Emily L. , Stimpson Madeleine L. , Lait Philippa J. P. , Schewitz‐Bowers Lauren P. , Jones Lauren V. , Dhanda Ashwin D. , Lee Richard W. J. , Bradbury Charlotte A.
Published: December 2020

Immune thrombocytopenia (ITP) is thought to result from an aberrant adaptive autoimmune response, involving autoantibodies, B and T lymphocytes, directed at platelets and megakaryocytes. Previous reports have demonstrated skewed CD4+ T‐helper subset distribution and enhanced production of pro‐inflammatory cytokines such as interleukin 17A and interferon gamma. The role of monocytes (MCs) in ITP is less widely described, but innate immune cells have a role in shaping CD4+ T‐cell phenotypes. Glucocorticoids (GCs) are commonly used for first‐line ITP treatment and modulate a broad range of immune cells including T cells and MCs. Using multiparameter flow cytometry analysis, we demonstrate the expansion of intermediate MCs (CD14++CD16+) in untreated patients with newly diagnosed ITP, with these cells displaying a pro‐inflammatory phenotype, characterised by enhanced expression of CD64 and CD80. After 2 weeks of prednisolone treatment (1 mg/kg daily), the proportion of intermediate MCs reduced, with enhanced expression of the anti‐inflammatory markers CD206 and CD163. Healthy control MCs were distinctly different than MCs from patients with ITP before and after GC treatment. Furthermore, the GC‐induced phenotype was not observed in patients with chronic ITP receiving thrombopoietin receptor agonists. These data suggest a role of MCs in ITP pathogenesis and clinical response to GC therapy.
Mortality and Finiteness
Authors: Handa Satoshi
Published: December 2020

Using Money‐Kyrle's concept of the facts of life, the author takes up the difficulty for a therapist in accepting his mortality and the finiteness of things. He reports two cases of once‐weekly psychotherapy during which he had to take a three‐month period of sick leave. In the first case, the patient created a timeless prison where the therapist and the patient were fused to avoid separation, which meant, to the patient, violent death. The author describes how his own acceptance of the fear of death helped them to face the patient's murderous hatred. The second case is of a patient with a huge and strong body who denied his own need and dependency. The therapist was at first unaware of being caught up in narcissistic competition with the patient. However, the realization that he was envious of the patient enabled him to accept his own weakness, which in turn helped the patient to show his vulnerability. Finally, the author argues that although it is human nature to deny death, we need to face death if we are to face life. He argues that there is perpetual oscillation between acceptance and denial of our mortality and the finiteness of things.
Prognostic relevance of adding MRI data to WHO 2016 and cIMPACT‐NOW updates for diffuse astrocytic tumors in adults. Working toward the extended use of MRI data in integrated glioma diagnosis
Authors: Roux Alexandre , Tran Stéphane , Edjlali Myriam , Saffroy Raphaël , Tauziede‐Espariat Arnault , Zanello Marc , Gareton Albane , Dezamis Edouard , Dhermain Frédéric , Chretien Fabrice , Lechapt‐Zalcman Emmanuèle , Oppenheim Catherine , Pallud Johan , Varlet Pascale
Published: December 2020

Assess the contribution of preoperative MRI data in improving grading of adult astrocytomas reclassified according to the WHO 2016 and cIMPACT‐NOW update 3. Retrospective unicentric cohort study of 679 adult patients treated for newly diagnosed diffuse astrocytic and oligodendroglial tumors (January 2006–December 2016). We first systematically compared radiological (contrast enhancement present [CE+] vs. absent [CE−]) and histopathological findings (microvascular proliferation present [MPV+] vs. absent [MPV−]) to validate whether this comparing step of neoangiogenesis represents an efficient method to appreciate the representativity of the tumoral sampling. We focused on 629 cases of astrocytomas for radio‐histological integrated analyses. In 598 cases (95.1%), neoangiogenesis evaluated by MRI or histology (CE+/MPV+ or CE−/MPV−) was identical. For the CE+/MPV− and CE−/MPV+ groups (23 cases), the radio‐histological face‐to‐face evaluation allowed us to assess that for 13 cases (56.5%) the reason for this discrepancy was an undersampled tumor. We analyzed the group of CE+/MPV− (n = 8) and CE−/MPV+ (n = 2) in verified image‐guided tumoral samples. Finally, we identified three new prognostic subgroups for molecular glioblastomas: (1) “non‐representative sampling” (n = 9), (2) “Non neoangiogenic glioblastoma at the time of diagnosis, without contrast enhancement and microvascular proliferation” (n = 8), and (3) “contrast enhancing glioblastoma but without microvascular proliferation in a representative sample” (n = 4). Neoangiogenesis processes should be assessed to improve the prognosis accuracy of the current integrated diagnosis. We suggest adding imaging analyses during the neuropathological analysis of astrocytomas in adults.
Presenting problem profiles for adolescents with ADHD: differences by sex, age, race, and family adversity
Authors: Coxe Stefany , Sibley Margaret H. , Becker Stephen P.
Published: December 2020

Background

Adolescents with attention‐deficit/hyperactivity disorder (ADHD) experience developmentally distinct challenges from children and adults with ADHD. Yet no work in this age group identifies treatment‐related phenotypes that can inform treatment matching, development of tailored treatments, and screening efforts.

Method

This study uses Latent Profile Analysis to detect unique presenting problem profiles among adolescents with ADHD and to test whether these profiles differ by key individual characteristics (age, sex, race, family adversity level). Participants were 854 ethnically diverse adolescents (ages 10–17) from the ADHD Teen Integrative Data Analysis Longitudinal (TIDAL) dataset who were assessed at clinical referral. Parent, adolescent, and teacher ratings, educational testing, and school records measured eight key presenting problems at intake.

Results

A three‐profile solution emerged. ADHD simplex (63.7%) was characterized by a mix of the ADHD‐Inattentive and ADHD‐Combined subtypes, moderate impairment levels, and infrequent comorbidities. ADHD + internalizing (11.4%) was characterized by higher likelihood of comorbid anxiety and/or depression. The disruptive/disorganized ADHD (24.9%) profile was characterized by severe organization, time management, and planning (OTP) problems, the ADHD‐Combined subtype, and frequent disruptive behavior at school. Age did not vary across these phenotypes. More females were present in the ADHD + internalizing phenotype; males were more likely to be found in the disruptive/disorganized ADHD phenotype. Higher family adversity and African American race were associated with the disruptive/disorganized ADHD phenotype.

Conclusions

Adolescents with ADHD demonstrate varying presenting problem phenotypes that vary by sex, family adversity, and race/ethnicity. Consideration of these phenotypes may inform treatment matching and efforts to improve screening among under‐diagnosed groups.
Implant framework misfit: A systematic review on assessment methods and clinical complications
Authors: Pan Yu , Tsoi James K. H. , Lam Walter Y. H. , Pow Edmond H. N.
Published: December 2020

Background

The fit of implant‐supported prostheses is of prime importance for the long‐term success of implant therapy.

Purpose

This systematic review aimed to evaluate recent evidence on current techniques for assessing implant‐framework misfit, its associated strain/stress, and whether these misfits are related to mechanical, biological, and clinical consequences.

Materials and methods

An electronic search for publications from January 2010 to October 2020 was performed using the Pubmed, Embase, Web of Science, and Cochrane Library databases with combined keywords on implant‐framework misfit assessments and related clinical complications. Inclusion and exclusion criteria were applied. After full‐text analyses, data extraction was implemented on current techniques of misfit assessment and the relationship between the misfit and the induced strain/stress.

Results

A total of 3 in vivo and 92 in vitro studies were selected, including 47 studies on quantifying the degree of implant‐framework misfit with dimensional techniques, 24 studies measuring misfit‐induced strain/stress with modeling techniques, and 24 studies using both methods. The technical details, advantages, and limitations of each technique were illustrated. The correlation between the implant‐framework misfit and the induced strain/stress has been revealed in vitro, while that with the biological complications and implant/prostheses failure was weak in clinical studies.

Conclusions

Dimensional and modeling techniques are available to measure the implant‐framework misfit. The passivity of implant‐supported fixed prostheses appeared related to the induced strain/stress, but not the clinical complications. Further studies combining three‐dimensional (3D) assessments using dimensional and modeling techniques was needed.
Total‐evidence backbone phylogeny of Aleocharinae (Coleoptera: Staphylinidae)
Authors: Orlov Igor , Leschen Richard A.B. , Żyła Dagmara , Solodovnikov Alexey
Published: December 2020

Phylogenetic studies of Aleocharinae rove beetles, arguably one of the least known and the largest insect lineages, are compromised by its enormous taxonomic diversity. DNA, a powerful resource for phylogenetics, is not available for numerous extant aleocharine species. We provide a broad comparative morphological study of Aleocharinae to frame molecular datasets for total‐evidence analyses. Using full‐body dissections and slide‐mounting techniques for light microscopy supplemented by scanning electron microscopy, we constructed a morphological matrix across all major taxa focused on non‐inquiline tribes of Aleocharinae and outgroups. Phylogenetic analyses of this matrix concatenated with earlier published DNA loci and including exemplar taxa lacking molecular data, resolved outstanding controversies and, among other novelties, showed that: the Habrocerinae + Trichophyinae clade is sister group to Aleocharinae; Hypocyphtini are sister to the rest of the “higher Aleocharinae”; Taxicerini are sister to Aleocharini; Hoplandriini and Placusini are nested within a polyphyletic Oxypodini; Hoplandriini are sister to Meoticina; and Actocharini are nested within Liparocephalini. For the first time, morphological synapomorphies are identified for some large clades of Aleocharinae. In addition, 1252 high‐resolution microphotographs of aleocharine structures are made available online with the entire matrix for future research.
Benefits of overwintering in the conservation breeding and translocation of a critically endangered amphibian
Authors: Calatayud Natalie E. , Hammond Talisin T. , Gardner Nicole R. , Curtis Michelle J. , Swaisgood Ronald R , Shier Debra M.
Published: December 2020

At high altitudes, amphibians brumate (over winter) during the winter months, an adaptation that provides protection from harsh weather and minimizes metabolic demand when food resources are scarce. However, brumation in ex situ populations is often avoided due to concerns regarding slow growth rates, compromised immunity, and increased morbidity, and to accelerate growth and sexual maturation. Running counter to these ideas is the hypothesis that husbandry that mimics the environmental conditions under which a species evolved may benefit animal health and reproduction. This may be particularly critical for animals slated for release into the wild. Here, we evaluated the effects of brumation on juvenile southern mountain yellow‐legged frogs (Rana muscosa) in a conservation breeding and release program. Growth measurements, (weight and snout‐urostyle length [SUL]), were examined in three experimental groups: Nonbrumated, 1 or 3‐month brumation. Postrelease survival was also analyzed and compared between nonbrumated and 3‐month brumated frogs. This study indicates that brumated R. muscosa juveniles grow to sizes and weights similar to controls within 3 to 4 months following brumation. Mark‐recapture models suggested that short‐term postrelease survival was not lower and in fact, may be higher in brumated compared to nonbrumated frogs. Results of this study indicate that although brumation entails short‐term costs to growth, this species possesses compensatory growth mechanisms following brumation which allow them to attain similar body size to nonbrumated conspecifics in time for the next winter and that for frogs destined for translocation to the wild, brumation could improve survival outcomes.
Development of the Fearless, Tearless Transition model of care for adolescents with an intellectual disability and/or autism spectrum disorder with mental health comorbidities
Authors: Culnane Evelyn , Loftus Hayley , Efron Daryl , Williams Katrina , Di Iorio Nikki , Shepherd Rebecca , Marraffa Catherine , Lubitz Lionel , Antolovich Giuliana , Prakash Chidambaram
Published: December 2020

Aim

First, to understand the barriers to achieving effective transition and the supports required from the perspective of parents and carers, adolescents with intellectual disability and/or autism spectrum disorder and co‐existing mental health disorders (often termed ‘dual disability’), and those who provide services to this group. Second, to develop an informed model of shared care to improve the transition of adolescents with dual disabilities.

Method

Carers and a young adult with a dual disability were surveyed about their experience of transition care. Other key stakeholders including paediatricians, general practitioners, and policy makers were also interviewed. These data informed the model of care.

Results

Paediatricians and general practitioners reported difficulties establishing working relationships to foster smooth transitions, and carers reported lacking a regular general practitioner with adequate expertise to care for people with dual disabilities. A process of shared care between paediatricians and general practitioners was developed and initiated by a dedicated transition manager, who assisted with care coordination and service linkages. Standardized clinical assessment tools were also introduced to determine patient and carer support needs.

Interpretation

This study highlights the potential to improve transition outcomes for adolescents with dual disabilities and their carers through early transition planning, consistent methods of assessing patient and carer needs, and shared care.

What this paper adds

Adolescents with co‐occurring disabilities require a collaborative health and disability service interface.

Fearless, Tearless Transition is a new approach to transitioning adolescents with dual disabilities from paediatric to adult care.

Carers of adolescents with dual disabilities require support navigating and negotiating services.

Engaging general practitioners and paediatricians in shared care early during the transition process is essential.
Clinical pointers from developing self‐awareness
Authors: Rochat Philippe
Published: December 2020

Seven typical developmental steps are described as cardinal changes leading children from implicit embodied self‐awareness at birth, self‐consciousness by 2 years, and the adoption of an ethical stance toward others by the preschool years (3–5y). This development may be a useful benchmark for clinicians. In this review, some clinical pointers are outlined in relation to each developmental step, but with a particular focus on the testing of self‐awareness in children with developmental disorders, including autism spectrum disorder, cerebral palsy, and intellectual disability.

What this paper adds

There are seven major steps in early self and social awareness.

Clinical pointers related to each of the seven steps are provided.
Financial inclusion and economic status of the states of India: An empirical evidence
Authors: Ghosh Shantanu , Sahu Tarak Nath
Published: December 2020

Financial inclusion, especially for a developing nation like India, plays a vital role in framing policies to ensure the development of the underprivileged. Applying the maximum–minimum technique for normalization and inverse of the Euclidean distance for consolidation, the present study attempts to construct an index of financial inclusion across all the states and union territories of India for 2003–2018. It further explores the effect of regional classifications and productivity on the achievement of financial inclusion. Analysis suggests Chandigarh be placed at the top in terms of mean financial inclusion scores for the study period. In addition, comparison among the regional classifications advocates for significant differences. Whereas the difference between the groups based on productivity remains nonsignificant. Theoretical propositions expect uniform achievement in financial inclusion among the states of a country. However, certain macroeconomic and other factors seem to reduce the esteemed equity.
Face‐like configurations modulate electrophysiological mismatch responses
Authors: Galigani Mattia , Ronga Irene , Bruno Valentina , Castellani Nicolò , Rossi Sebastiano Alice , Fossataro Carlotta , Garbarini Francesca
Published: December 2020

The human face is one of the most salient stimuli in the environment. It has been suggested that even basic face‐like configurations (three dots composing a downward pointing triangle) may convey salience. Interestingly, stimulus salience can be signaled by mismatch detection phenomena, characterized by greater amplitudes of event‐related potentials (ERPs) in response to relevant novel stimulation as compared to non‐relevant repeated events. Here, we investigate whether basic face‐like stimuli are salient enough to modulate mismatch detection phenomena. ERPs are elicited by a pair of sequentially presented visual stimuli (S1‐S2), delivered at a constant 1‐s interval, representing either a face‐like stimulus (Upright configuration) or three neutral configurations (Inverted, Leftwards, and Rightwards configurations), that are obtained by rotating the Upright configuration along the three different axes. In pairs including a canonical face‐like stimulus, we observe a more effective mismatch detection mechanism, with significantly larger N270 and P300 components when S2 is different from S1 as compared to when S2 is identical to S1. This ERP modulation, not significant in pairs excluding face‐like stimuli, reveals that mismatch detection phenomena are significantly affected by basic face‐like configurations. Even though further experiments are needed to ascertain whether this effect is specifically elicited by face‐like configuration rather than by particular orientation changes, our findings suggest that face essential, structural attributes are salient enough to affect change detection processes.
Basomedial amygdala activity in mice reflects specific and general aversion uncontrollability
Authors: Ineichen Christian , Greter Alexandra , Baer Mischa , Sigrist Hannes , Sautter Eva , Sych Yaroslav , Helmchen Fritjof , Pryce Christopher R.
Published: December 2020

Learning adaptive behaviour to control aversion is a major brain function. Detecting the absence of control is also important, although chronic uncontrollable aversion can impact maladaptively on stimulus processing in general. The mouse basomedial amygdala (BMA) contributes to aversion processing with high BMA activity associated with active behavioural responding. The overall aim of the present study was to investigate the associations between aversion (un)controllability, BMA activity and behaviour. Fibre photometry of GCaMP6‐expressing BMA neuron populations was applied in freely behaving adult male mice during exposure to mild electrical shocks, and effects of specific or general (un)controllability were investigated. In a discrete learned helplessness (LH) effect paradigm, mice underwent discrete sessions of pre‐exposure to either escapable shock (ES) or inescapable shock (IES) followed by an escape test. IES mice acquired fewer escape attempts than ES mice, and this co‐occurred with higher aversion‐related BMA activity in the IES group. After 30 days, ES and IES mice were allocated equally to either chronic social stress (CSS)—exposure to continuous uncontrollable social aversion—or control handling (CON), and on days 5 and 15 underwent an IES session. CSS mice made fewer escape attempts than CON mice, and this was now associated with lower aversion‐related BMA activity in the CSS group. These findings suggest that mouse BMA activity is higher when discrete aversion is uncontrollable but becomes lower following chronic uncontrollable aversion exposure. Therefore, BMA activity could be a neural marker of adaptive and maladaptive states consequent to specific and general uncontrollability, respectively.
Christ‐Centred Solidarity in a Time of Pandemic
Authors: Muers Rachel
Published: December 2020

The article proposes a reading of Colossians 1:15‐20 for the time of COVID‐19, arguing that the assertion that all things “hold together” in the incarnate Christ should lead Christians not only to practise solidarity with those most at risk, but also to evaluate societal and systemic responses to COVID‐19 in the light of their effects on the most vulnerable members of society. The article considers the use and misuse of the rhetoric of self‐sacrificial love or loving self‐sacrifice, and the use and misuse of the image of warfare – arguing that in both of these areas, Christian communities offer urgent challenges and correctives on the basis of their traditions of Christ‐centred solidarity.
Your Neighbour Is Yourself Reflected in the Mirror of Life
Authors: Sheqi Nitoli , Kaunda Chammah J.
Published: December 2020

This paper engages with the narrative of the Good Samaritan from a Naga perspective in the context of COVID‐19. It demonstrates how Naga Indigenous hospitality, as opposed to contemporary Christianized hospitality in Nagaland, has an affinity with the teaching of Jesus in the narrative. The pertinent question it raises is what the Good Samaritan hospitality would look like if articulated from an Indigenous context during a pandemic. The paper argues that through rereading the story of the Good Samaritan, the Naga churches and society in general have the potential to reclaim and engage Naga’s Indigenous culture of hospitality that supersedes ethnicity in the ongoing pandemic.
Playing God during the Pandemic
Authors: de Gruchy John W.
Published: December 2020

According to Dietrich Bonhoeffer, in extraordinary situations, when the accepted norms of ethics do not provide clear‐cut answers and even prevent responsible action, human beings must act freely in conformity to the incarnate, crucified, and risen Christ. Being conformed to his incarnation means being involved fully and vicariously in the life and struggles of the world; being conformed to his crucifixion means identifying with the suffering of the victims and being in solidarity with the oppressed; and being conformed to his resurrection means living and acting in hope for the sake of future generations. In seeking to express the love of Christ in the midst of our present‐day pandemic, we are called to act in response to the question “Who is Jesus Christ for us today?” In this way, “Christ’s love moves the world to reconciliation and unity,” not just during a pandemic such as we have experienced, but also at this time in world history when enmity and discord have once again become rampant.
“Everything Is Interrelated”
Authors: Kerber Guillermo
Published: December 2020

The COVID‐19 pandemic has shown that “everything is interrelated,” especially in relation to health, ecology, economy, and climate change, as various authors have stated. The motto is the leitmotif of Pope Francis’ encyclical Laudato si’ and leads to his proposal of an integral ecology. This article deepens the implications of the latter in the encyclical and in other works and shows how the Catholic Synod of Bishops for the Pan‐Amazon Region is an example of the reception and application of integral ecology in a given context. Based on this, the article proposes some conclusions, taking into account the theme of the next assembly of the World Council of Churches in 2022.
“A Mosaic Community Together in the Journey of Faith”
Authors: Kim Afia Sun , Kaunda Chammah J.
Published: December 2020

This article demonstrates how missional churches have emphasized accompaniment as missiological foundation in the COVID‐19 pandemic season. Employing ethnographical method, interviews, and virtual church visits as the primary approach, the paper explores how NextGen Church as the embodiment of Christ’s love has moved communities to solidarity and unity in the middle of global suffering. It concludes that God is on the mission of love and that the pandemic has provided an opportunity for the church to enhance its participation in missio Dei by epitomizing Christ’s love.
Safety, pharmacokinetics and pharmacodynamics of a topical SYK inhibitor in cutaneous lupus erythematosus: A double‐blind Phase Ib study
Authors: Walker Alex , Erwig Lars , Foster Katie , Nevin Katherine , Wenzel Joerg , Worm Margitta , Williams Nicola , Ratia Nirav , Hoang Bao , Schneider‐Merck Tanja , Gisbert Sophie , Carnarius Heike , Dickson Marion
Published: December 2020

The immunoregulator spleen tyrosine kinase (SYK) is upregulated in cutaneous lupus erythematosus (CLE). This double‐blind, multicentre, Phase Ib study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamics and clinical efficacy of the selective SYK inhibitor GSK2646264 in active CLE lesions. Two lesions from each participant (n = 11) were each randomized to topical application of 1% (w/w) GSK2646264 or placebo for 28 days; all participants received GSK2646264 and placebo. The primary endpoint was safety and tolerability of GSK2646264, assessed by adverse event incidence and a skin tolerability test. Secondary endpoints included change from baseline in clinical activity and mRNA expression of interferon‐related genes in skin biopsies. Levels of several immune cell markers were evaluated over time. Eight (73%) participants experienced ≥ 1 adverse event (all mild in intensity), and maximal dermal response was similar for GSK2646264 and placebo. The expression of several interferon‐related genes, including CXCL10 and OAS1, showed modest decreases from baseline after 28 days of treatment with GSK2646264 compared with placebo. Similar findings were observed for CD3 + T cell and CD11c + dendritic cell levels; however, overall clinical activity remained unchanged with GSK2646264 vs. placebo. Further studies are warranted to assess SYK inhibitors as potential treatment for CLE.
Anisomycin sensitizes non‐small‐cell lung cancer cells to chemotherapeutic agents and epidermal growth factor receptor inhibitor via suppressing PI3K/Akt/mTOR
Authors: Tan Hongxia , Hu Biao , Xie Fan , Zhu Chuanbing , Cheng Zhenshun
Published: December 2020

The poor outcomes in advanced non‐small‐cell lung cancer (NSCLC) necessitate new treatments. Recent studies emphasize anisomycin as a promising anti‐cancer drug candidate. In this work, we systematically investigated the efficacy of anisomycin alone and its combination with the standard‐of‐care drugs in NSCLC. We showed that anisomycin inhibited growth, migration, and survival in NSCLC cells regardless of genetic mutation status, and to a greater extent than in normal lung epithelial cells. Isobologram analysis showed that the combination of anisomycin with cisplatin, paclitaxel, or gefitinib was synergistic in NSCLC but not normal lung cells. We further demonstrated that anisomycin inhibited NSCLC growth in mice. The combination of anisomycin with cisplatin was more effective than cisplatin alone and completely arrested NSCLC growth throughout the whole duration of treatment. JNK and p38 MAPK were not required for anisomycin’s action. In contrast, anisomycin inhibits PI3K/Akt/mTOR pathway. Overexpression of constitutively active Akt reversed the pro‐apoptotic effect of anisomycin. Our work demonstrates the selective anti‐NSCLC activity of anisomycin via suppressing PI3K/Akt/mTOR. Our findings provide preclinical evidence to initialize the clinical trial of using anisomycin to sensitize NSCLC to current therapy.