bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPLEMENTASI PENDEKATAN SAINTIFIK DAN PENILAIAN OTENTIK DALAM PEMBELAJARAN PENDIDIKAN PANCASILA DAN KEWARGANEGARAAN DI SMAN 7 BOGOR
Authors: Saylendra Nadya Putri , Danial Endang
Published: May 2020

This research is purposed to know how the implementation of scientific approach and authentic assessment in civics and citizenship in SMAN 7 Bogor. This research employed a descriptive  methods from qualitative research.The results showed that teacher has understanding on the scientific approach and authentic assessment in the study of civic education. The planning of scientific approach and authentic assessment in civic education has been carried out thoroughly. The implementation of scientific approach and authentic assessment in study of civic and citizenship, the teacher has demonstrated the stages of scientific approach and processing score into value using the existing assessment format. The scientific approach and authentic assessment showed an objective results of student learning competencies; such as attitude, skills and knowledge.
ETNISITAS, POLITIK, DAN PEMBANGUNAN NEGARA BANGSA DI MALAYSIA
Authors: Maiwan Mohammad
Published: May 2020

Malaysia is a multiethnic country, in which ethnic factors as the basis of political interests. So far, efforts to create national integration have been directed at strengthening relations between ethnic groups and creating a political balance for all peoples. Efforts to build a nation state are conducted through policy: political cooperation, economic affirmation for ethnic Malays, education, and strengthening the position of Malay as the national language. The challenge to the nation state development in Malaysia emerged during the economic crisis of 1998. The conflict brought political divisions among Malaysians, especially Malays. After Mahathir Mohamad's reign, efforts to promote national unity were carried out by introducing a moderate and tolerant concept of Islam Hadhari. During the leadership of Najib Razak, efforts to build a nation state were undertaken under the idea of One Malaysia. One of the challenges of developing a nation today is: The widening of gaps, racial prejudices, increased group identity, intolerance and corruption.
PENGARUH KUALITAS KEHIDUPAN KERJA DAN SIKAP KERJA TERHADAP KEPUASAN KERJA GURU SMA NEGERI KECAMATAN JEKAN RAYA KOTA PALANGKA RAYA PROVINSI KALIMANTAN TENGAH
Authors: Khoiri Moh.
Published: May 2020

This study aims to determine the effect of (1) the quality of work life, (2) working attitude, (3) job satisfaction of teachers working SMA Kecamtan Jekan Kingdom city of Palangkaraya , Central Kalimantan Province. In the data analysis, this study used a survey method using a causal analysis technique Strip . This study used a sample of 138 teachers in three high schools in District Jekan Kingdom city of Palangkaraya are selected using Slovin formula.The results showed that : first , there are positive influence between the quality of work life and job satisfaction of teachers in schools . Secondly , there is a positive effect between work attitudes and job satisfaction of teachers in schools . Third , there is a positive effect between the quality of working life and work attitudes of teachers in schools.
KESIAPAN PENDIDIK PAUD DALAM MENGAJAR ANAK USIA DINI DI KOTA BANDUNG
Authors: Sari Lisna Sulinar
Published: May 2020

The research was conducted aimed at finding out about the readiness of PAUD educators in teaching seen from: 1) recruitment of PAUD educators provided by PAUD managers in the city of Bandung; and 2) academic qualifications and competencies of PAUD educators in the city of Bandung. This research was conducted with a qualitative approach. Respondents are principals or managers of PAUD and PAUD educators in the city of Bandung. Data were obtained throught focus group discussion, and questionnaire. The results showed that the recruitment of PAUD educators was conducted in various ways, such as making announcements, making classified advertisements in newspapers, there were also job seekers coming directly to PAUD institutions to register as PAUD educators, and even looking through the help of friends. There are still many academic qualifications for early childhood education in the city of Bandung, but for TPA all PAUD educators are already undergraduates, but there are those who are S2 but non-educational scholars. The competencies possessed by PAUD educators are also different. The competence of TK, KB and SPS educators mostly reaches the level of affordability, but there are a small number of TPA educators who have disabilities in pedagogic competencies. The aspects of pedagogic competence that cannot be mastered by TPA teachers are, they are unable to carry out remedial and enrichment programs.
DEMOKRASI DAN TANTANGANNYA DALAM BINGKAI PLURALISME DI INDONESIA
Authors: Nur Syurya Muhammad
Published: May 2020

Artikel ini membahas tentang berlangsungnya demokrasi di Indonesia. Sebagai negara dengan penduduk muslim terbesar, bagaimana nilai-nilai Islam mempengaruhi berjalannya demokrasi di negara ini. Indonesia memiliki 1.331 kelompok suku dan 652 bahasa daerah. Dengan kemajemukan tersebut negara ‘mengajarkan’ tentang toleransi dan pluralisme melalui semboyan yang dikenal ‘Bhineka Tunggal Ika’, berbeda-beda namun tetap satu jua. Nilai-nilai demokrasi, agama, dan pluralisme juga terkandung dalam dasar negara, Pancasila. Meski begitu, demokrasi di Indonesia mengalami pasang surut. Tantangan terbesar saat ini adalah menguatnya politik identitas
COVER VOLUME 19 NOMOR 1 Oktober 2019
Authors: JIMD Editor
Published: May 2020

COVER VOLUME 19 NOMOR 1 Oktober 2019
Hypoglossal Nerve Palsy After Anterior Cervical Spine Surgery
Authors: Colón Luis Felipe , Isaza Jorge , Katsuura Yoshihiro , Nuss Daniel
Published: May 2020

Case:

A 37-year-old man was found to have hypoglossal nerve palsy after undergoing anterior cervical spine surgery at C3-C5, an injury that would cause him severe disability and further complications.

Conclusion:

Knowledge of the hypoglossal nerve is crucial for cervical spine surgery even at lower levels (C4-C7), including variations in its course and potential displacement during the induction of anesthesia.
Multicomponent Diffusion Modeling of Cyclic Solvent Injection in Ultratight Reservoirs
Authors: Cronin Michael , Emami-Meybodi Hamid , Johns Russell T.
Published: May 2020

We present a new semianalytical compositional model designed for primary production of multicomponent oil and cyclic solvent injection in ultratight oil reservoirs that is dependent on diffusion-dominated transport within the matrix (k < 200 nd) coupled to advection-dominated transport in the fractures. The semianalytical model consists of a well-mixed tank model for the fractures coupled to diffusive transport within the matrix. Production of oil, gas, and water from the fractures to the well is proportional to its phase mobility. The matrix allows for differing effective-diffusion coefficients for each component. Because there are no gridblocks within the matrix, the analytical solution is computationally less expensive than numerical simulation while capturing the steep, nonmonotonic compositional changes occurring a short distance into the matrix that result from multiple injection cycles. The Peng-Robinson equation of state (PR EOS) (Robinson and Peng 1978) is used to calculate phase behavior with time within the fractures and to initialize density and mass concentrations within the matrix based on the semianalytical framework.

The coupled convective (fracture) and diffusive (matrix) model is validated with several laboratory- and field-scale cases. For primary recovery, the results show that the model correctly reproduces the pressure and oil-recovery declines observed in the field. We show that the hydrocarbon-recovery mechanism for solvent huff ’n’ puff (HnP) is facilitated by greater density reduction and compositional changes. Two solvents are considered in HnP calculations: carbon dioxide (CO2) and methane (CH4). Recovery of heavier components is enhanced with CO2 compared with CH4 within the reservoir (matrix and fractures). Furthermore, the results demonstrate that multiple HnP cycles constrained to surface injection are needed to enhance density and compositional gradients, and therefore oil recovery. Although shorter soaks are better for short-term recovery (i.e., 3 to 5 years), longer soaks maximize recovery over a longer time frame (i.e., 10 to 15 years). This paper provides a limiting case model based on diffusive matrix transport and convective fracture transport to determine the optimal number/duration of cycles and when to start the HnP process after primary recovery.
Assessment of the proportion and the factors associated with partner and family based index case HIV testing in Woliso town, Oromia, Ethiopia: a cross-sectional study
Authors: Haile Teka , Gulema Hanna
Published: May 2020

Background: Despite the enormous expansion of HIV testing services (HTS), an estimated 40% of people with HIV infection remain undiagnosed. In Ethiopia, the current working UNAIDS spectrum estimate for PLHIV is 649,264, of the estimated PLHIV, only about 72% know their status. Methods: A facility based cross-sectional study design with internal comparison was conducted among randomly selected 346 people currently on ART in Woliso town. Data entry carried out by Epi Info™ version 7.2.3.1 and analyzed using SPSS version 21.0 statistical software for Windows.Results: Among 345 study participants, 333 (96.5%) with 95 % CI (94.5 - 98.3) of index cases have tested families. The odds of HIV testing were 7.22 times higher among those who disclosed their HIV status (AOR=7.22 95% CI: 1.45, 35.82) compared to those who did not disclosed. Those who have stayed <12 months on ART are 87% less likely to have tested families (AOR=0.13 95% CI: 0.03, 0.63) compared to those who stayed ≥12 months on ART. Conclusion: this study finding shows that higher proportions of families of index cases have been tested for HIV. It also shows that partner and family based index case HIV testing has significant association with HIV status disclosure of index cases and the length of the duration that the index cases stayed on ART. It is essential to sustain the platform of partner and family based index case HIV testing service through strengthening disclosure counselling and assisting HIV status disclosure in health facilities with fully trained provider and qualified health providers. It also suggests the need to focus on those who received ART for less than 12 months duration and communicate on the timing of HIV testing for HIV negative families with ongoing risk of acquiring HIV.
Early Guillain-Barré syndrome in COronaVIrus Disease 2019 (COVID-19): a case report from an Italian COVID-Hospital
Authors: Ottaviani Donatella , Boso Federica , Tranquillini Enzo , Gapeni Ilaria , Pedrotti Giovanni , Cozzio Susanna , Guarrera Giovanni M. , Giometto Bruno
Published: May 2020

Guillain Barré syndrome (GBS) is an acute polyradiculoneuropathy associated with dysimmune processes, often related to a previous infectious exposure. During Italian Severe Acute Respiratory Syndrome Coronavirus-2 outbreak, a woman presented with a rapidly progressive flaccid paralysis with unilateral facial neuropathy after a few days of mild respiratory symptoms. Coronavirus was detected by nasopharyngeal swab, but there was no evidence of its presence in her cerebrospinal fluid, which confirmed the typical albumin-cytological dissociation of GBS, along with consistent neurophysiological data. Despite immunoglobulin infusions and intensive supportive care, her clinical picture worsened simultaneously both from respiratory and neurological point of view, as if reflecting different aspects of the same systemic inflammatory response. Similar early complications have already been observed in patients with para-infectious GBS related to Zika virus, but pathological mechanisms have yet to be established.
Differential Parameters between Activity Flare and Acute Infection in Pediatric Patients with Systemic Lupus Erythematosus
Authors: Luo Kai-Ling , Yang Yao-Hsu , Lin Yu-Tsan , Hu Ya-Chiao , Yu Hsin-Hui , Wang Li-Chieh , Chiang Bor-Luen , LEE JYH-HONG
Published: May 2020

Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease. SLE patients are vulnerable to infections. Infections might mimic and even trigger SLE flares. To distinguish acute infection from activity flare always remains a clinical challenge.We aim to explore the approach to differentiate active infection from disease activity in pediatric SLE patients.Methods: Fifty pediatric SLE patients presenting with 185 clinical episodes were collected.The associations betweenrelevant data encompassing both clinical and laboratory parameters and the outcome groups were analyzed using generalized estimating equations (GEEs)facilitatingthe analysis of data collected in longitudinal and repeated-measures designs.We also used a multinomial logistic regression model for simultaneous prediction of different outcome groups. Finally, we ran the GLIMMIX procedure to track trends of changes in parameters over time.Results: These 185 episodes were divided into 4 outcome groups: infected-active (n=102), infected-inactive (n=11), noninfected-active (n=59), and noninfected-inactive (n=13) episodes. Multivariate GEE analysis showed that SDI, SLEDAI-2K, neutrophil‐to‐lymphocyte ratio (NLR), hemoglobin, platelet, RDW-to-platelet ratio (RPR), and C3 are predictive of flare (combined calculated AUC of 0.8964 and with sensitivity of 82.2 % and specificity of 90.9%). Multivariate GEE analysis showed that SDI, fever temperature, CRP, procalcitonin, lymphocyte percentage, NLR, hemoglobin, and renal score in SLEDAI-2k are predictive of infection (combinedcalculated AUC of 0.7886 and with sensitivity of 63.5% and specificity of 89.2%). We developed regression equations for simultaneous prediction of 4 different outcome groups.We could differentiate noninfected-active from infected-active episodes by different change patterns of ESR, NLR, lymphocyte, C3, and C4 over time.Conclusions: The proposed approach could differentiateflares from infections in pediatric SLE patients. Combination of parameters from four different domains simultaneously, including inflammation (CRP, ESR, PCT), hematology (Lymphocyte percentage, NLR, PLR), complement (C3, C4), and clinical status (SLEDAI, SDI), is effective to make appropriate judgement and treatment decisions.
Innate Lymphoid Cell Disturbance in Henoch-Schonlein Purpura
Authors: Zhang Lili , Lin Qiang , Wu Mingfu , Jiang Lijun , Huang Linlin , Li Xiaozhong
Published: May 2020

Background: Innate lymphoid cells (ILCs) are tissue-residentlymphoidcellswhichare enriched inthe barrier surfaces andparticipateininitialimmuneresponseagainstpathogens.Itisreportedthat ILCs are dysfunctional in various human diseases. ILCs is the bridge between innate immunity and adaptive immunity, while Henoch-Schonlein purpura (HSP)meet these characters, early innate and later adaptive immune response. Submucosal lymphotissue is mainly IgA produced area, where ILCs resident. Increasing data confirmed thatmucosal immune and IgA is related with HSP. The relationship between ILCs and HSP (IgA vasculitis) remains unclear.Methods:ILCs subsets and lymphocyte subpopulation were characterized in the peripheral blood (PB)of normal controls and patients of HSPand the cell surface markers expression were detected by flow cytometry. We also correlated the frequencies of each ILCs subset in PB with lymphocyte subpopulation and serum IgA in HSP patients.Results: The difference of ILCs/Lymphocytes andILCs/PBMC in patientswithHSP andnormalcontrols was statistically significant. The proportion of ILC1 significantly increased and ILC3 decreased in HSP patients. Moreover, the percentage of ILC1 significantly decreased and ILC3 increased in HSP patients after treatment. The difference of ILCs/Lymphocytes and ILCs/PBMC in the arthritis type and mixed type of HSP was also statistically significant in comparison with normal controls.Conclusions: Our study indicates that the increased circulating ILC3 and decreased circulating ILC1 might be helpful for the pathogenesis of HSPthrough mediating type 3 immune response?
An outcome evaluation of an environmental nutrition intervention conducted in an institute of higher learning in Singapore: A cluster-randomized trial
Authors: Seah Sharna S.Y. , Dam Rob M. van , Tai Bee Choo , Tay Zoey , Wang May C. , Rebello Salome A.
Published: May 2020

Objective

Evidence for effective food environment interventions to improve the quality of out-of-home foods is limited in Asia. The Healthier Dining Programme (HDP) is a voluntary government programme designed to increase the availability and accessibility of healthier foods and beverages at eateries in Singapore, a multi-ethnic, urbanized and developed nation. The objective of our study was to evaluate effects of the HDP on the out-of-home dietary intakes of consumers at an institute of higher learning.
Design/Setting:

We used a cluster-randomized trial design. Six food centers (two food courts and four canteens) at a large university campus were randomly assigned to the intervention or control arm. Participants were university students or staff aged ≥ 18 years (n = 408) who frequently dined at these six food centers. Relevant data were gathered by interview and a 7-day food diary before and after 10 weeks of the intervention. Generalized estimating equations for logistic and linear regression were used to assess the difference in intake of out-of-home healthier dishes between the two study arms.
Results

Participants in the intervention arm were more likely to have at least one healthier out-of-home dish per week as compared to those in the control arm (84% vs. 65%, unadjusted OR: 2.79 95% CI: 1.59, 4.88). This was due mainly to the higher consumption of dishes prepared with healthier oil blends (unadjusted OR: 3.24 95% CI: 1.95, 5.38) and lower-sodium salt (unadjusted OR: 4.36 95% CI: 1.64, 11.58) in the intervention arm. Whilst saturated and polyunsaturated fat intake in the two arms were comparable, participants in the intervention arm had lower total fat (-1.27 g/1000 kcal, 95% CI: -2.48, -0.06) and monounsaturated fat intakes (-0.50 g/1000 kcal, 95% CI: -0.94, -0.06), from out-of-home dishes as compared with the control arm.
Conclusions

These findings suggest that environmental interventions at institutes of higher learning to increase healthier food availability and accessibility can improve dietary intake from out-of-home foods.
Role of Pediococcus Acidilactici J9 in Decreasing the Occurrence of Gastritis Caused by H.pylori Infection and Two-week Repeated-dose Oral Toxicity Study in Mice
Authors: Lee Mijung , Chung Jin-Young , Kim Ka Yeun , Im Wooseok , Kim Manho
Published: May 2020

BACKGROUND Helicobacter pylori (H. pylori) is an important pathogen that causes chronic gastritis and peptic ulcer, and is related to the development of gastric carcinoma. Several chemicals, including antibiotics, have been used to eradicate H.pylori. However, more studies are yet requred to accomplish a sufficient therapy. Pediococcus acidilactici J9 were studied for inhibition of binding of H.pylori binding to human gastric cell lines. This study was performed in order to investigate the repeated-dose toxicity of Pediococcus acidilactici J9 in male and female mice.RESULTS C57BL/6 male and female Mus musculus were divided into four groups (n = 10 in each group). Pediococcus acidilactici J9 was administered daily by oral injection of vehicle control at dosage levels to a low-dose group (500 mg/kg/day), middle-dose group (1000 mg/kg/day), and high-dose group (2000 mg/kg/day) for two weeks. After 14 days of exposure, the blood biochemistry and hematology were investigated, along with a histopathology exam. There were no bacterial-related deaths or abnormal clinical signs in either gender of mouse. The data was observed during the period in terms of body weight, food, intake, and water consumption. Also, no alterations in organ weights upon administration of Pediococcus acidilactici J9 alone were observed.CONCLUSIONS These results suggest that the oral application of Pediococcus acidilactici J9, up to a dosage level of 2,000 mg/kg/day, causes no adverse effects in both male and female mice. Pediococcus acidilactici J9 inhibits the adhesion of H.pylori to AGS gastric cancer cells. When used as probiotics, Pediococcus acidilactici J9 may help decrease the occurrence of gastritis and reduce the risk of H.pylori infection with promising safety issues.
Menstrual blood-derived mesenchymal stem cells provide new insights into the treatment of coronavirus disease 2019 (COVID-19)
Authors: Chen Xin , Yu Liang , Chen Lijun , Zheng Xiaoqin , Tang Lingling , Xu Kaijin , Cai Hongliu , Chen Yu , Zheng Shufa , Lu Juan , Xu Zhenyu , Zhang Qiang , Gao Hainv , Li Yifei , Qu Jingjing , Jiang Yingan , Xu Xiaowei , Xiang Charlie , Li Lanjuan
Published: May 2020

Background: The coronavirus disease 2019 (COVID-19) causing a cluster of respiratory infections in Wuhan, China, is identified in December 2019. The main symptoms are defined as fever, cough, shortness of breath, with early symptom of sputum, acute respiratory distress syndrome (ARDS), and the final lung injury and pulmonary fibrosis. Currently, there is no effective method to cure it. Mesenchymal stem cell (MSC) therapy is an immediate need for treating COVID-19 especially severe patients at present.Methods: We describe the two confirmed case of COVID-19 severe patients in Hangzhou, China to explore the role of menstrual blood-derived MSC in the treatment of SARS-CoV-2 infection. Furthermore, we mimic disease model of pulmonary fibrosis in mice to assess the role of MSC. Then, a co-culture system to investigate the underlying mechanism between MSC and pulmonary-associated cells by a series of Physiological, biochemical, bioinformatics analysis.Results: MSC transplantation increases the immune indicators (including lymphocytes) and decreases inflammatory indicators (such as IL-6, IL-10, TNF, and IFN). More importantly, the two patients alleviated symptom and discharged after 3 weeks’ treatment with MSC. Additionally, MSCs exhibit an anti-inflammatory role through suppressing some inflammatory factors (RANTES, GM-CSF, MIG-1g, MCP-5, Eotaxin), which is anastomotic to current clinical study using MSC to treat COVID-19. Conclusions: This is the first report using menstrual blood-derived MSC in treating COVID-19 patients. From our clinical results, we hold one idea that MSCs reduced inflammatory effect to defend cytokine storm. The underlying mechanism is probably that MSCs inhibit epithelia cell apoptosis and reduce the secretion of inflammatory factors to prevent myofibroblasts activity. MSC provides an alternative method for treating COVID-19 particularly some patients with ARDS or subsequent pulmonary fibrosis.Trial registration: This clinical trial was submitted to and approved by the Ethics Committee of the First Affiliated Hospital, Collage of Medicine, Zhejiang University. MSC administration in patient with COVID-19 was conducted in a single center and open-label clinical trial (ChiCTR2000029606).
Home range expansion in response to temperature by evening bats (Nycticeius humeralis) in an urban environment
Authors: Hall Ellen , Bennett Victoria
Published: May 2020

Background: Despite the negative connotation of urban sprawl for bat populations, fragmented green spaces such as parks, cemeteries, and golf courses have the potential to provide necessary resources for bats. For example, water resources in these areas can include natural or semi-natural lakes, ponds, streams, and drainage ditches. Such water resources, however, are frequently ephemeral when subject to prolonged periods of high temperatures. We, therefore, hypothesize that bats will expand or shift their home ranges from these urban green spaces into the surrounding neighborhoods to access alternative resources, such as residential swimming pools. Methods: To explore whether bats expand their ranges from urban green spaces, we conducted a telemetry study in which we radio-tracked resident evening bats (Nycticeius humeralis) in a local park system during their summer activity period from 2017-2019 in Fort Worth, Texas, USA. From radio-tracking surveys, we measured home range size using a k-LoCoH method and the percentage of these home ranges that fell within the park system. We compared these variables using linear and non-linear regressions with temperature. Results: We successfully tracked a total of 30 bats over the 3-year period and found a positive correlation between home range size and temperature. Furthermore, we observed that home ranges increased 6 times in size when temperatures exceeded 30ºC. Conclusions: Our study indicates the importance of urban neighborhoods surrounding green spaces in providing alternative resources, such as water, for bats. If managed appropriately, these urban areas have the potential to act as urban oases for bat populations, which in turn can contribute to their conservation.
The value of lung involvement in recognizing severe dengue-A retrospective study
Authors: Shi Yunfeng , Gan Weiqiang , Shi Xiaohan , Liang Jingjing , Chen Xiaoxia , Guo Yuefei , Tong Yuwei , Gao Zhiliang , Wu Benquan
Published: May 2020

Background Dengue fever is a vector-borne disease transmitted by infected female Aedes mosquitoes. It has become the major threat to human beings especially in tropical and subtropical areas. It's important to find early parameters to identify severe dengue due to its poor prognosis. This study aimed to explore the value of lung involvement in identifying severe dengue (SD) from ordinary dengue.Methods 592 dengue patients admitted in the Third Affiliated Hospital of Sun Yat-sen University from July 2014 to January 2020 were enrolled. Patients were divided into two groups, dengue with lung involvement group (DWLI) and dengue without lung involvement group (DWOLI). According to the severity of dengue fever, patients in DWLI group were further divided into dengue subgroup and SD subgroup. The clinical characteristics, treatment and outcome of the patients were analyzed between groups and subgroups respectively.Results The rate of SD patients was higher in DWLI group than that in DWOLI group. The ratios of old age, smoking, hepatobiliary disease, hypertension, diabetes, coronary heart disease and cerebrovascular disease were higher in DWLI group than those in DWOLI group (all p<0.05). Other organs such as liver, kidney, digestive tract were affected more in DWLI group (all p<0.05). Respiratory symptoms such as cough and breathlessness were more common in DWLI group (both p<0.05). Subgroup analyses showed that SD subgroup patients had more respiratory symptoms as well (p<0.05). Inflammatory markers including C-reactive protein (CRP) and pro-calcitonin (PCT) were increased in DWLI group (both p<0.05). The ratios of pleural effusion and bilateral lung infiltration were correlated with SD (both p<0.05). The ratios of anti-virus，anti-bacteria and combined therapy were higher in DWLI group. There were 10 cases in DWLI group complicated with multiple organ dysfunction syndrome (MODS) while no MODS occurred in DWOLI group. Except for 2 patients with MODS died, all the other patients were cured.Conclusions Among dengue fever patients, the elderly, smoking population, those accompanied by underlying diseases were prone to have lung involvement. Dengue fever patients who develop clinical manifestations such as cough, breathlessness, pleural effusion and bilateral pneumonic exudation should be warned of SD.
Foraging and commuting habitats of the greater horseshoe bat, revealed by high-resolution GPS-tracking
Authors: Fujioka Emyo , Yoshimura Koki , Ujino Tomohiro , Yoda Ken , Fukui Dai , Hiryu Shizuko
Published: May 2020

Background Echolocating bats make a series of decisions to select their flight routes based on auditory information obtained by sonar; accumulations of these flight routes are represented as daily movement patterns. However, there is still a lack of a unified understanding of continuous movements of echolocating bats in the wild from small to large spatial scales (i.e., from meters to tens of kilometers). In this study, we investigated nightly flight paths of the Japanese greater horseshoe bat, Rhinolophus ferrumequinum nippon, using high-resolution GPS data loggers. Our aim was to identify foraging and commuting behavior based on the observed movement patterns and to investigate the relationship between these movement types and specific habitats.Results We found that the majority of tagged bats alternated between foraging and commuting behavior throughout the tracking period, and one individual moved 23.6 km from its roost. The bats usually left a stay point in the opposite direction from which they entered it, indicating that almost all of the stay sites were on their way to another destination. The distance between two successive foraging sites was on average 332 ± 398 m (mean ± standard deviation), and half of all foraging periods lasted less than 3 min. An analysis of habitat use revealed that the bats used conifer plantation and natural forests as pathways and feeding habitats.Conclusions Our findings suggest that the structure of the forests have a great influence on the nocturnal behavior of the greater horseshoe bats. Although this study has a descriptive character due to a relatively small number of tagged individuals, it was possible to elucidate the small-scale interactions between wild Rhinolophus bats and their environment using the latest high-resolution GPS technology, which will allow us to give new insights into the foraging ecology of echolocating bats in the wild.
Analyzing the determinants of the spread of covid-19 among the provincial regions in China
Authors: Shen Jianfa
Published: May 2020

China has experienced the spatial diffusion of covid-19 from Wuhan since December 2019. This research examines the relationship between the geographical, social and economic factors and the number of covid-19 cases on 26 January, 7 February, 20 February and 6 March 2020 in mainland China. Both correlation and regression analyses show that the migrants who moved into Hubei in 2005-2010 is a good indicator of the population flow from Hubei to other provinces that caused the spread of covid-19 in early 2020. Many migrants travelled back to hometown just before the traffic ban of Wuhan city for the spring holiday. Thus the migration flow from a province to Hubei in the period 2005-2010 had the highest correlation coefficient with the number of covid-19 cases in four selected dates. The population flow data from the Baidu map on 20 January 2020 were also highly correlated with the number of cases, but not as good as above migration data. The regression equation for the number of cases on 26 January 2020 had the highest adj R2 as it was mainly determined by the population flow from Hubei. The numbers of cases in subsequent days were also affected by the local diffusion and the control measure in various provinces. Income and economic variables became additional explanatory variables indicating their complicated impacts on the mitigation measures at various provinces in China. The results of this research have important policy implications to respond to the covid-19 pandemic.
WITHDRAWN: Lysenin toxin insertion mechanism is Calcium-dependent
Authors: Munguira Ignacio L.B.
Published: May 2020

Pore Forming Toxins (PFTs), formed mainly by virulence factors of bacteria, belongs to Pore Forming Protein (PFP) family. Secreted as soluble monomers, they bind specific targets in membranes where their oligomerization and insertion place. Lysenin, a member of the PFTs, forms and oligomer after sphingomyelin binding, the so-called prepore, which become inserted forming a pore after a conformational change triggered by a pH decrease. In crowded conditions, oligomers tends to stay in prepore form because the prepore-to-pore transition is sterically blocked. In this study, we investigate the effect of calcium ions in those crowded conditions, finding that calcium act as a trigger for lysenin insertion. We localize the residues responsible for calcium sensitivity in a small α-helix. Our results are not only one of the few complete structural descriptions of prepore-to-pore transitions but the very first that involves a calcium triggering mechanism. The presence of glutamic or aspartic acids in the insertion domains could be an indication that calcium may be a general trigger for PFTs and more generally PFP.
Drug repurposing and polypharmacology to fight SARS-CoV-2 through the inhibition of the main protease
Authors: Pinzi Luca , Tinivella Annachiara , Caporuscio Fabiana , Rastelli Giulio
Published: May 2020

There is an urgent need to develop therapeutic options to fight the outbreak of a novel Coronavirus (SARS-CoV-2), which causes a disease named COVID-19 and is spreading rapidly around the world. Drug repurposing can significantly accelerate the identification of drug candidates suitable for clinical evaluation. Moreover, drugs with polypharmacological effects may increase antiviral activity and/or counteract severe disease complications concurrently affecting COVID-19 patients. Herein, we present the results of a computational drug repurposing campaign in search for potential inhibitors of the main protease of SARS-CoV-2. To this aim, the complete DrugBank database, including drug metabolites, was docked to the recently solved crystal structure of the SARS-CoV-2 Mpro and the results were post-processed by using our in-house tool BEAR. Here we report 32 promising drugs that could be repositioned to fight SARS-CoV-2. Some of them have already entered clinical trials against COVID-19, thus supporting our results, but the vast majority of the selected compounds is new and has never been considered before. For each repurposed compound its therapeutic relevance and the potential beneficial polypharmacological effects that may arise thanks to its original therapeutic indication are thoroughly discussed.
A RESPONSABILIDADE DO FRANQUEADOR PELOS DÉBITOS TRABALHISTAS DO FRANQUEADO
Authors: PELEGRINI Pedro
Published: May 2020

O âmago do presente estudo é aclarar a possibilidade de responsabilização do franqueador por débitos trabalhistas de seu franqueado. O instituto da franquia se faz cada vez mais presente na rotina dos brasileiros, devido a sua grande seguridade institucional, bem como a sua alta rentabilidade. Apesar de ser modelo de renome entre os moldes de negócios, o instituto da franchising carrega consigo algumas dúvidas. A eventualidade de existir compromisso do franqueador adimplir débitos trabalhistas do franqueado é uma dessas questões, pois se essa for deflagrada, o fascínio pelo retro citado instituto pode vir a diminuir. Serão levantadas ao longo deste exame, três probabilidades da referida responsabilização. Duas delas, envolvendo outras figuras jurídicas consolidadas e sua aplicação e enquadramento ao instituto da franquia, à saber, terceirização e grupo econômico; bem como uma probabilidade doutrinária e social, a situação de hipossuficiência do trabalhador mediante o seu empregador. Ao fim, buscar-se-á esmiuçar a incidência dos os institutos, respeitando o ordenamento jurídico e o egrégio entendimento, sem penalizar a efígie da franquia. Perscrutaremos demonstrar que no desenvolvimento perfeito da franchising, não há como haver a questionada responsabilização, isto é, na incidência exata do disposto ao contrato de franquia, a obrigação de arcar com eventuais débitos trabalhistas do franqueado, está completamente afastada do franqueador. Para que tal relação obrigacional ganhe subsistência, carece de mutação nos moldes da franquia, ou seja, deturpação no que fora previamente alinhavado.
Contribution of Morphological Variables in Garlic Bulb Yield
Authors: Teixeira de Oliveira Job , Alves de Oliveira Rubens , França da Cunha Fernando , da Silva Ribeiro Isabela , Almeida Oliveira Lucas Allan , Teodoro Paulo Eduardo
Published: May 2020

The objective of this work was to investigate the direct and indirect relationships of morphological variables on garlic bulb yield. The primary components of garlic bulb yield, including clove mass, number of cloves per bulb, and bulb diameter and bulb length, are the variables that affect garlic bulb yield directly. Leaf length and growth of a secondary bulb had a negative correlation to garlic bulb yield. Growth of a secondary bulb also had a negative correlation with the number of cloves per bulb and root dry mass. Irrigation with the deficit, applied at the stage of bulb formation, had a positive correlation with garlic yield and a slightly negative correlation with total plant mass, bulb length, and secondary bulb growth.
Magnetite texture and trace-element geochemistry fingerprint of pulsed mineralization in the Xinqiao Cu-Fe-Au deposit, Eastern China
Authors: Zhang Yu , Hollings Pete , Shao Yongjun , Li Dengfeng , Chen Huayong , Li Hongbin
Published: May 2020

The origin of stratabound deposits in the Middle-Lower Yangtze River Valley Metallogenic Belt (MLYRB), Eastern China, is the subject of considerable debate. The Xinqiao Cu-Fe-Au deposit in the Tongling ore district is a typical stratabound ore body characterized by multi-stage magnetite. A total of six generations of magnetite have been identified. Mt1 is commonly replaced by porous Mt2, and both are commonly trapped in the core of Mt3, which is characterized by both core-rim textures and oscillatory zoning. Porous Mt4 commonly truncates the oscillatory zoning of Mt3, and Mt5 is characterized by 120° triple junction texture. Mt1 to Mt5 are commonly replaced by pyrite that coexists with quartz, whereas Mt6, with a fine-grained foliated and needle-like texture, commonly cuts the early pyrite as veins and is replaced by pyrite that coexists with calcite. The geochemistry of the magnetite suggests that they are hydrothermal in origin. The microporosity of Mt2 and Mt4 magnetite, their sharp contacts with Mt1 and Mt3, and lower trace-element contents (e.g., Si, Ca, Mg, and Ti) than Mt1 and Mt3 suggest that they formed via coupled dissolution and reprecipitation of the precursor Mt1 and Mt3 magnetite, respectively. This was likely caused by high-salinity fluids derived from intensive water-rock interaction between the magmatic-hydrothermal fluids associated with the Jitou stock and Late Permian metalliferous black shales. The 120° triple junction texture of Mt5 suggests it is the result of fluid-assisted recrystallization, whereas Mt6 formed by replacement of hematite as a result of fracturing. The geochemistry of the magnetite suggests that the temperature increased from Mt2 to Mt3 and implies that there were multiple pulses of fluids from a magmatic-hydrothermal system. Therefore, we propose that the Xinqiao stratiform mineralization was genetically associated with multiple influxes of magmatic hydrothermal fluids derived from the Early Cretaceous Jitou stock. This study demonstrates that detailed texture examination and in situ trace-elements analysis under robust geological and petrographic frameworks can effectively constrain the mineralization processes and ore genesis.
Kaynaştırma Sınıflarında Özel Eğitim Alan Öğrencilere Yönelik Öğretmen Davranışlarına İlişkin Rehberlik Öğretmenlerinin Görüşleri
Authors: DEMİRBİLEK Mesut , LEVENT Faruk
Published: May 2020

Bu
çalışmanın amacı, devlet okullarında kaynaştırma öğrencilerine yönelik öğretmen
davranışlarına ilişkin rehberlik öğretmenlerinin görüşlerini incelemektir.
Nitel araştırma yöntemlerinden fenomenoloji deseniyle yürütülmüş olan bu
çalışmanın verileri, yarı yapılandırılmış görüşme formu kullanılarak elde
edilmiştir. Araştırma kapsamında, İstanbul ili Çekmeköy ve Sancaktepe
ilçelerinde bulunan farklı okul türlerinde görev yapan 20 rehberlik öğretmeni
ile yüz yüze görüşme yapılmıştır. Elde edilen veriler, nitel araştırma
yöntemleri doğrultusunda kodlanarak temalar altında toplanmış ve betimsel
analize tabi tutulmuştur. Rehberlik öğretmenlerinin görüşlerine göre genel
olarak öğretmenler, kaynaştırma öğrencilerine yönelik BEP planlarına gereken
özeni göstermemekte ve bunu gereksiz iş yükü olarak değerlendirmektedir.
Bununla birlikte öğretmenlerin; kaynaştırma öğrencilerinin fark edilmesinde
yeterli bilgiye sahip olmadıkları, özel eğitim ve kaynaştırma bilgilerinin
yetersiz olduğu ve öğrenci yetersizliklerine göre öğretimlerini
çeşitlendirmediklerini ifade etmişlerdir. Aynı zamanda katılımcılar, öğretmenlerin;
bu öğrencileri sınıf ortamında pasif bıraktıkları, görmezden geldikleri,
problemli ve engelli öğrenciler olarak gördükleri, bu öğrencilerden yüksek akademik
beklenti içerisinde oldukları, sınıflarında istemediklerini, bu öğrencilerin
gelişebileceklerine ve öğrenebileceklerine inanmadıklarını için not verirken
geçiştirdiklerini belirtmişlerdir. Rehberlik öğretmenleri, okullarda kaynaştırma
öğrencilerine ilişkin olumsuz öğretmen davranışlarını önlemeye yönelik hizmet
içi eğitim programlarının düzenlenmesi gerektiğini önermektedirler.
Rencana Penerapan Cyber-Risk Management Menggunakan NIST CSF dan COBIT 5
Authors: Ashari Rizqi Aulia
Published: May 2020

Kemajuan Teknologi Informasi dan Komunikasi (TIK) membentuk ruang siber sehingga memudahkan akses informasi maupun pengelolaan informasi secara cepat dan akurat. Pemanfaatan TIK yang meningkat saat ini membuat kebutuhan keamanan pada sistem yang digunakan juga meningkat, begitu pula risikonya. Untuk mengatasi hal tersebut, perlu diterapkan cyber-risk management sehingga risiko-risiko siber dapat dikelola. Organisasi ABC merupakan salah instansi pemerintah pengelola infrastruktur kritis negara. Sistem informasi XYZ merupakan SI strategis yang digunakan untuk membantu pimpinan dalam pengambilan keputusan. Dalam penelitian ini, diusulkan rencana penerapan cyber-risk management menggunakan NIST CSF dan COBIT 5 untuk mengelola risiko-risiko siber pada sistem informasi XYZ. Hasil penelitian berupa 13 risiko bernilai tinggi dan 22 risiko bernilai sedang disertai dengan enabler process COBIT 5 sebagai mitigasi risiko. Dari hasil tersebut kemudian disusun 15 rencana aksi (program kerja) penerapan cyber-risk management sesuai dengan kapabilitas dan target organisasi. Rencana aksi tersebut kemudian diprioritaskan sesuai kepentingan organisasi.
EVALUATION OF INFRASTRUCTURE READINESS IN SUPPORTING THE IMPLEMENTATION OF E-GOVERNMENT USING THE COBIT 5 FRAMEWORK. CASE STUDY: PADANGSIDIMPUAN CITY GOVERNMENT
Authors: Siregar Alfiansyah Halomoan , Hermadi Irman , Wahjuni Sri
Published: May 2020

The application of information technology (IT) has now become a necessity in all aspects of both individuals, groups or organizations and even government institutions. The implementation of IT in government is a form of execution of the President's instruction No. 3 of 2003 concerning national policies and strategies for the development of e-government. IT infrastructure itself is a foundation and framework that supports a system or organization. Excellent IT infrastructure support will contribute to accelerating the achievement of organizational goals. Evaluation of IT infrastructure readiness in Diskominfo in Padangsidimpuan City is done using the COBIT framework, by measuring the maturity level of IT infrastructure governance that refers to IT management goals number 10 and 11 in COBIT that are mapped on 13 COBIT process domains. The results of the evaluation of the level of achievement in each process there are eight processes at the completion of levels 1 and five are at the achievement of level 0. The level of hope for achieving the whole process is at level 3 and the gap consists of 2 degrees and 3 levels of achievement. The recommendations given in the form of a SWOT in this study aim to increase the level of maturity of IT infrastructure governance to support the implementation of e-government in the city government of Padangsidimpuan.
Data Quality Management in Educational Data
Authors: Wilantika Nori , Wibowo Wahyu Catur
Published: May 2020

Every varsity in Indonesia is responsible for ensuring the completeness, the validity, the accuracy, and the currency of its educational data. The educational data is used for implementing higher-education quality assurance system and formulating policies related to universities and majors in Indonesia. Data quality assessment result indicates that educational data in Statistics Polytechnic did not meet completeness, validity, accuracy, and currency criteria. Data quality management maturity has been measured using Loshin’s Data Quality Maturity Model which result is in level 1 to level 2 of maturity. Only the data quality dimensions component has achieved the expected target. Thus, recommendations have been proposed based on the DAMA-DMBOK framework. The activities needed to be carried out are developing and promoting awareness of data quality; defining data quality requirements; profiling, analyzing, and evaluating data quality; define business rules for data quality, establish, and evaluate the data quality services levels, manage problems related to data quality, design and implement operational procedures for data quality management, and monitor operations and performance of data quality management procedures.
Utilization of the Business Process Maturity Model as a Proposed Architectural Planning of Business Model Concept
Authors: Wahyu Sawali , Husni S. Sastramihardja
Published: May 2020

This research is a part of previous research which succeeded in producing business model architecture planning, the purpose of this research is to develop previous research using business model maturity measurement methods as a proposed business model architecture planning concept. By taking the same case study theme as Tiara Payung Putra (TPP) company. TPP is known as a distributor company in cooperation with Pertamina's (Bulk LPG Filling and Filling Station). TPP's main business activity is to distribute goods in the form of LPG to 76 bases spread across the Balaraja district. The current condition of the business model architecture illustrates the business activities that exist in the TPP. The main problems that occur in the TPP are not integrated the external system with internal business activities in the company, and the lack of IT resource support. For this reason, the Business Process Maturity Model is needed as a benchmark, which can be proposed as a business architecture planning concept. Support for the Enterprise Architecture Planning (EAP) Framework method focuses on the business model architecture domain. The architecture of the business model illustrates how TPP carries out business activities and functions to achieve its objectives. The results of this study produce proposed business model architecture planning concepts in the form of Business Model Maturity Level Measurement, SI / IT architecture concepts, and Business Architecture Planning roadmap, which are beneficial for Tiara Payung Putra (TPP) company for business model architecture planning.