bluuebunny/crossref_metadata_2025 huggingface dataset:
Local Space, Global Life
Authors: Eslava Luis
Published: August 2015

Local Space, Global Life engages with the expansive, ground-level and intertwined operations of international law and the development project by discussing the current international focus on local jurisdictions. Since the mid-1980s, and through the discourse of decentralization, municipalities and cities in emerging nations have become the preferred spaces in which to promote global ideals of human, economic and environmental development. Through an ethnographic study of Bogotá's recent development experience and the city's changing relation to its illegal neighbourhoods, Luis Eslava interrogates this rationale and exposes the contradictions involved in the international turn to the local. Attentive to historical and current transformations, norms and praxis, and both ideology and materiality, he provides an innovative reading of the nature of international law and the development project, and reveals their impact on local spaces and lives at the urban periphery of today's world order.
Puberty in Crisis
Authors: Roberts Celia
Published: August 2015

Puberty has long been recognised as a difficult and upsetting process for individuals and families, but it is now also being widely described as in crisis. Reportedly occurring earlier and earlier as each decade of the twenty-first century passes, sexual development now heralds new forms of temporal trouble in which sexuality, sex/gender and reproduction are all at stake. Many believe that children are growing up too fast and becoming sexual too early. Clinicians, parents and teachers all demand something must be done. Does this out-of-time development indicate that children's futures are at risk or that we are entering a new era of environmental and social perturbation? Engaging with a diverse range of contemporary feminist and social theories on the body, biology and sex, Celia Roberts urges us to refuse a discourse of crisis and to rethink puberty as a combination of biological, psychological and social forces.
British Art and the First World War, 1914–1924
Authors: Fox James
Published: August 2015

The First World War is usually believed to have had a catastrophic effect on British art, killing artists and movements, and creating a mood of belligerent philistinism around the nation. In this book, however, James Fox paints a very different picture of artistic life in wartime Britain. Drawing on a wide range of sources, he examines the cultural activities of largely forgotten individuals and institutions, as well as the press and the government, in order to shed new light on art's unusual role in a nation at war. He argues that the conflict's artistic consequences, though initially disruptive, were ultimately and enduringly productive. He reveals how the war effort helped forge a much closer relationship between the British public and their art - a relationship that informed the country's cultural agenda well into the 1920s.
Fictions of Mass Democracy in Nineteenth-Century America
Authors: Margolis Stacey
Published: August 2015

Fictions of Mass Democracy in Nineteenth-Century America examines how mass democracy was understood before public opinion could be measured by polls. It argues that fiction, in its freedom to represent what resists representation, develops the most groundbreaking theories of the democratic public. These literary accounts of democracy focus less on overt pubic action than the profound effects of everyday social encounters. This book thus departs from recent scholarship, which emphasizes the responsibilities of citizenship and the achievements of oppositional social movements. It demonstrates how novels and stories by Charles Brockden Brown, Edgar Allan Poe, Nathaniel Hawthorne, Herman Melville, Fanny Fern, Harriet Jacobs and James Fenimore Cooper attempt to understand a public organized not only by explicitly political discourse, but by informal and disorganized social networks.
Hume and the Politics of Enlightenment
Authors: Merrill Thomas W.
Published: August 2015

'Methinks I am like a man, who having narrowly escap'd shipwreck', David Hume writes in A Treatise of Human Nature, 'has yet the temerity to put out to sea in the same leaky weather-beaten vessel, and even carries his ambition so far as to think of compassing the globe'. With these words, Hume begins a memorable depiction of the crisis of philosophy and his turn to moral and political philosophy as the path forward. In this groundbreaking work, Thomas W. Merrill shows how Hume's turn is the core of his thought, linking Hume's metaphysical and philosophical crisis to the moral-political inquiries of his mature thought. Merrill shows how Hume's comparison of himself to Socrates in the introduction to the Treatise illuminates the dramatic structure and argument of the book as a whole, and he traces Hume's underappreciated argument about the political role of philosophy in the Essays.
Nineteenth-Century American Literature and the Long Civil War
Authors: Marrs Cody
Published: August 2015

American literature in the nineteenth century is often divided into two asymmetrical halves, neatly separated by the Civil War. In Nineteenth-Century American Literature and the Long Civil War, Cody Marrs argues that the war is a far more elastic boundary for literary history than has frequently been assumed. Focusing on the later writings of Walt Whitman, Frederick Douglass, Herman Melville, and Emily Dickinson, this book shows how the war took imaginative shape across, and even beyond, the nineteenth century, inflecting literary forms and expressions for decades after 1865. These writers, Marrs demonstrates, are best understood not as antebellum or postbellum figures but as transbellum authors who cipher their later experiences through their wartime impressions and prewar ideals. This book is a bold, revisionary contribution to debates about temporality, periodization, and the shape of American literary history.
Inequalities for Graph Eigenvalues
Authors: Stanić Zoran
Published: August 2015

Written for mathematicians working with the theory of graph spectra, this book explores more than 400 inequalities for eigenvalues of the six matrices associated with finite simple graphs: the adjacency matrix, Laplacian matrix, signless Laplacian matrix, normalized Laplacian matrix, Seidel matrix, and distance matrix. The book begins with a brief survey of the main results and selected applications to related topics, including chemistry, physics, biology, computer science, and control theory. The author then proceeds to detail proofs, discussions, comparisons, examples, and exercises. Each chapter ends with a brief survey of further results. The author also points to open problems and gives ideas for further reading.
EPISTEMOLOGY AND RADICALLY EXTENDED COGNITION
Authors: Jarvis Benjamin
Published: August 2015

This paper concerns the relationship between epistemology and radically extended cognition. Radically extended cognition (REC) – as advanced by Andy Clark and David Chalmers – is cognition that is partly located outside the biological boundaries of the cognizing subject. Epistemologists have begun to wonder whether REC has any consequences for theories of knowledge. For instance, while Duncan Pritchard suggests that REC might have implications for which virtue epistemology is acceptable, J. Adam Carter wonders whether REC threatens anti-luck epistemology. In this paper, I argue that the possibility of REC has no systematic consequences for theorizing in epistemology. I suggest an alternative relationship between the two: epistemology can play a role in diagnosing cases of REC. Thus, by establishing that entities partially located outside biological boundaries don't play certain epistemic roles, one can establish that they don't play the related cognitive roles either. I conclude the paper by illustrating this last point.
THE (2,3)-GENERATION OF THE CLASSICAL SIMPLE GROUPS OF DIMENSIONS 6 AND 7
Authors: PELLEGRINI MARCO ANTONIO
Published: August 2015

In this paper, we prove that the finite simple groups $\text{PSp}_{6}(q)$, ${\rm\Omega}_{7}(q)$ and $\text{PSU}_{7}(q^{2})$ are $(2,3)$-generated for all $q$. In particular, this result completes the classification of the $(2,3)$-generated finite classical simple groups up to dimension 7.
ON UNICITY OF MEROMORPHIC SOLUTIONS TO DIFFERENCE EQUATIONS OF MALMQUIST TYPE
Authors: LÜ FENG , HAN QI , LÜ WEIRAN
Published: August 2015

In this note, we prove a uniqueness theorem for finite-order meromorphic solutions to a class of difference equations of Malmquist type. Such solutions $f$ are uniquely determined by their poles and the zeros of $f-e_{j}$ (counting multiplicities) for two finite complex numbers $e_{1}\neq e_{2}$.
Ecdysozoan-like sclerites among Ediacaran microfossils
Authors: MOCZYDŁOWSKA MAŁGORZATA , BUDD GRAHAM E. , AGIĆ HEDA
Published: August 2015

We report the occurrence of organically preserved microfossils from the subsurface Ediacaran strata overlying the East European Platform in Poland, in the form of sclerites and cuticle fragments of larger organisms. They are morphologically similar to those known from Cambrian strata and associated with various metazoan fossils of recognized phyla. The Ediacaran age of the microfossils is evident from the stratigraphic position below the base of the Cambrian System and above the isotopically dated tuff layers atc.551±4Ma. Within this strata interval, other characteristic Ediacaran microorganisms co-occur such as cyanobacteria, vendotaenids, microalgae,Ceratophyton,Valkyriaand macroscopic annelidanSabellidites. The recent contributions of organic sclerites in revealing the scope of the Cambrian explosion are therefore also potentially extendable back to the Ediacaran Period when animals first appear in the fossil record.
Optimised production and spray drying of ACE-inhibitory enzyme-modified cheese
Authors: Amighi Fatemeh , Emam-Djomeh Zahra , Madadlou Ashkan
Published: August 2015

The proteolytic stage of the digestion process of white cheese curd was optimised to maximise the angiotensin I-converting enzyme (ACE)-inhibitory activity of the final enzyme-modified cheese (EMC) paste. It was found that bioactive peptides generation in EMC paste was of multi-variable dependent nature and could be optimised by targeted selection of specific component variables. Maximum ACE-inhibitory was obtained by proteolysis at 48 °C for 25 h with 1 g Flavourzyme/kg cheese curd. This bioactive EMC paste was subsequently spray-dried. The drying conditions were optimised to obtain a highly soluble powder to warrant quick and complete hydration, with the lowest water activity to maximise long term storage. The higher the inlet drying air temperature, the greater was the solubility of resultant EMC powder. Differential scanning calorimetry analysis revealed that the highest drying air temperature (200 °C) resulted in a lower glass transition temperature for the potentially bioactive EMC powder.
Doestrans-10,cis-12 conjugated linoleic acid affect the intermediary glucose and energy expenditure of dairy cows due to repartitioning of milk component synthesis?
Authors: Benninghoff Jens , Metzger-Petersen Katrin , Tröscher Arnulf HA , Südekum Karl-Heinz
Published: August 2015

The overall goal of this study was to evaluate if intermediary energy metabolism of cows fed withtrans-10,cis-12 conjugated linoleic acid (CLA) was modified such that milk-energy compounds were produced with less intermediary energy expenditure as compared to control cows. Published data on supplemented CLA were assembled. The extent was calculated to which thetrans-10,cis-12 CLA isomer has an impact on glucose and energy conversion in the mammary gland by modifying glucose equivalent supply and energy required for fatty acid (FA) and fat synthesis, and if this will eventually lead to an improved glucose and energy status of CLA-supplemented high-yielding dairy cows. A possible relationship between CLA supplementation level and milk energy yield response was also studied. Calculations were conducted separately for orally and abomasally administered CLA and based on energy required for supply of glucose equivalents, i.e. lactose, glycerol and NADPH2. Further, modifications of milk FA profile due to CLA supplementation were considered when energy expenditures for FA and fat synthesis were quantified. Differences in yields between control and CLA groups were transformed into glucose energy equivalents. Only abomasal infusion (r2= 0·31) but not oral CLA administration (r2= 0·11) supplementation to dairy cow diets resulted in less glucose equivalent energy. Modifications of milk FA profiles also saved energy but the relationship with CLA supplementation was weaker for abomasal infusion (r2= 0·06) than oral administration (r2= 0·38). On average, 10 g/d of abomasally infusedtrans-10,cis-12 CLA saved 1·1 to 2·3 MJ net energy expressed as glucose equivalents, whereas both positive and negative values were observed when thetrans-10,cis-12 CLA was fed to the cows.

This study revealed a weak to moderate dose-dependent relationship between the amount oftrans-10,cis-12 CLA administered and the amount of energy in glucose equivalents and energy for the synthesis of milk fat conserved from milk ingredient synthesis. Because abomasal infusion of thetrans-10,cis-12 CLA more consistently conserved energy in glucose equivalents compared with oral CLA intake, rumen protection of the fed CLA products appears incomplete. Milk fat synthesis showed an energy saving with a weak dose-dependent relationship when CLA was supplemented orally or by abomasal infusion.
Turbulent fluxes of entropy and internal energy in temperature stratified flows
Authors: Rogachevskii I. , Kleeorin N.
Published: August 2015

We derive equations for the mean entropy and the mean internal energy in low-Mach-number temperature stratified turbulence (i.e. for turbulent convection or stably stratified turbulence), and show that turbulent flux of entropy is given by$\boldsymbol{F}_{s}=\overline{{\it\rho}}\,\overline{\boldsymbol{u}s}$, where$\overline{{\it\rho}}$is the mean fluid density,$s$is fluctuation of entropy and overbars denote averaging over an ensemble of turbulent velocity fields,$\boldsymbol{u}$. We demonstrate that the turbulent flux of entropy is different from the turbulent convective flux,$\boldsymbol{F}_{c}=\overline{T}\,\overline{{\it\rho}}\,\overline{\boldsymbol{u}s}$, of the fluid internal energy, where$\overline{T}$is the mean fluid temperature. This turbulent convective flux is well-known in the astrophysical and geophysical literature, and it cannot be used as a turbulent flux in the equation for the mean entropy. This result is exact for low-Mach-number temperature stratified turbulence and is independent of the model used. We also derive equations for the velocity–entropy correlation,$\overline{\boldsymbol{u}s}$, in the limits of small and large Péclet numbers, using the quasi-linear approach and the spectral${\it\tau}$approximation, respectively. This study is important in view of different applications to astrophysical and geophysical temperature stratified turbulence.
Finding pathways to human–elephant coexistence: a risky business
Authors: Songhurst Anna , McCulloch Graham , Coulson Tim
Published: August 2015

Finding ways for people and wildlife to coexist requires affording both parties access to critical resources and space, but also a behavioural change by both to avoid conflict. We investigated pathway use in a population of free-ranging African elephants Loxodonta africana in the Okavango Panhandle, Botswana that share their range with humans in a multi-use, heterogeneous landscape. We used detailed ground surveys to identify and map elephant movement pathways, and mixed-effect models to explore factors influencing elephant numbers and movement behaviour on and around these pathways. We found deviation in pathway use among the elephant population, suggesting behavioural adaptations to avoid human-associated risk: avoiding pathways near settlements, particularly near larger settlements; avoiding pathways close to cultivated land; and adopting a safety-in-numbers strategy when moving through areas of human use. Our findings suggest there is opportunity to capitalize on risk avoidance by elephant populations, to minimize resource-use overlap and reduce conflict between humans and elephants. We discuss a strategy that involves ensuring appropriate protection of elephant pathways in land-use planning, using development-free buffer zones, combined with mitigation techniques along the interface with agricultural lands to increase risk levels and reinforce human–elephant interface boundaries. We recommend further examination of the use of landscape-level mitigation techniques that encourage elephants to use pathways away from human activity and help define spatial boundaries for management of human–elephant conflict in multi-use landscapes.
Shelter crowding and increased incidence of acute respiratory infection in evacuees following the Great Eastern Japan Earthquake and tsunami
Authors: KAWANO T. , TSUGAWA Y. , NISHIYAMA K. , MORITA H. , YAMAMURA O. , HASEGAWA K.
Published: August 2015

Although outbreaks of acute respiratory infection (ARI) at shelters are hypothesized to be associated with shelter crowding, no studies have examined this relationship. We conducted a retrospective study by reviewing medical records of evacuees presenting to one of the 37 clinics at the shelters in Ishinomaki city, Japan, during the 3-week period after the Great Eastern Japan Earthquake and tsunami in 2011. On the basis of a locally weighted scatter-plot smoothing technique, we categorized 37 shelters into crowded (mean space <5·5 m2/per person) and non-crowded (⩾5·5 m2) shelters. Outcomes of interest were the cumulative and daily incidence rate of ARI/10 000 evacuees at each shelter. We found that the crowded shelters had a higher median cumulative incidence rate of ARI [5·4/10 000 person-days, interquartile range (IQR) 0–24·6,P= 0·04] compared to the non-crowded shelters (3·5/10 000 person-days, IQR 0–8·7) using Mann–WhitneyUtest. Similarly, the crowded shelters had an increased daily incidence rate of ARI of 19·1/10 000 person-days (95% confidence interval 5·9–32·4,P< 0·01) compared to the non-crowded shelters using quasi-least squares method. In sum, shelter crowding was associated with an increased incidence rate of ARI after the natural disaster.
INTRACELLULAR ORGANISMS AS PLACENTAL INVADERS
Authors: VIGLIANI MARGUERITE B. , BAKARDJIEV ANNA I.
Published: August 2015

In an era of evidence-based medicine, physicians sometimes forget the value of anecdotes in stimulating thought about clinical problems. Our recent report on typhoid fever in a pregnant woman at 12 weeks of gestation is a good example. In spite of culture-proven diagnosis and appropriate treatment of the mother with antibiotics, fetal loss occurred at 16 weeks of gestation. Salmonella typhi was found in the fetal lung on autopsy, consistent with vertical transmission of the organism. None of the clinicians caring for the patient had imagined that gram-negative bacteria could cross the placenta and kill the fetus in spite of early diagnosis and treatment with appropriate antibiotics.
REPRESENTING ANIMAL MINDS IN EARLY ANIMAL AUTOBIOGRAPHY: CHARLOTTE TUCKER'STHE RAMBLES OF A RATAND NINETEENTH-CENTURY NATURAL HISTORY
Authors: Smith Julie A.
Published: August 2015

Animal autobiography–a first-personfictional narrative in which an animal tells its own story – emerged in the late eighteenth century as the first attempt to represent animal minds in extended narrative form. Authors of this genre were anxious to create accurate, believable animal characters, even as they afforded them human language and a habit of critical commentary. To do this, they wrote in sync with scientific understandings of animals as set out in books of natural history. A few authors are explicit about their debt to natural history, and their comments point to a broad but intended compatibility between the ideas of animal minds in animal autobiography and those in the popularized scientific discourse of the day.
STATISTICAL CRITICISM AND THE EMINENT MAN IN FRANCIS GALTON'SHEREDITARY GENIUS
Authors: Berezowsky Sherrin
Published: August 2015

Inspired by the power and influencethat Charles Darwin attributed to heredity inOn the Origin of Species(1859), Francis Galton developed a program of eugenics that he believed could shape Britain's progress as a nation by managing the evolutionary development of the British race. InInquiries into Human Faculty and its Development(1883), Galton summarizes this aim as “to learn how far history may have shown the practicability of supplanting inefficient human stock by better strains, and to consider whether it might not be our duty to do so by such efforts as may be reasonable, thus exerting ourselves to further the ends of evolution more rapidly and with less distress than if events were left to their own course” (1–2). While this project, Galton's life's work, was largely a process of analysis and the development of dictates that could be put in place to shape the reproduction of the nation, it was also a project of imagination; not only was Galton himself imagining a different future for Britain, but in promoting his program, he appealed to the imaginations of his readers in an attempt to get them to share his vision.
The Relationships between Functional and Dysfunctional Impulsivity and Aggression across Different Samples
Authors: Vigil-Colet Andreu , Morales-Vives Fabia , Tous Jordi
Published: August 2015

E. S. Barratt proposed the term impulsive aggression to define a kind of aggression that is characterized by acting without thinking because of high levels of impulsivity. Previous research using psychometric measures has shown that impulsivity and aggression are related as far as psychometric measures are concerned. Nevertheless, most of the research has been done with samples of university students. Our research tests whether this relationship is stable across different samples; university students, teenagers and workers. Our results show that impulsivity and aggression have a consistent pattern of relationships across these samples, with impulsivity being specially related to emotional and instrumental aspects of aggression. Furthermore, the effects of anger on aggression seem to show a pattern of relationship that depends on age, with a tendency to physical aggression in young people and verbal aggression in adults.
The Future of Multilateralism: Governing the World in a Post-Hegemonic Era
Authors: IKENBERRY G. JOHN
Published: August 2015

Since the middle of the twentieth century, the governance of the global system has been organized around the United States and the advanced industrial democracies. In the shadow of the Cold War, these countries established a wide array of global and regional institutions to manage economic, political, and security relations. The Bretton Woods institutions, GATT (and later the WTO), the United Nations, and various functional institutions provided the bulwark for an open and managed postwar world economy and global order. An American-led alliance system provided a structure for regional security in Europe and East Asia. When the Cold War ended, these far-flung institutions were extended into a more fully global multilateral system of governance. The United States dominated the global order. But, more so than did leading states in previous eras, it established its dominance through institutions. It was an American-led liberal hegemonic order.
A Brief Case Study of Germany and Japan: Emotions and Passions in the Making of World War II
Authors: COICAUD JEAN-MARC
Published: August 2015

Competing interests among big powers played a role in the making of World War II. But, and not separated from this, another element had a serious impact: the sense of psychological insecurity experienced, each in its own way, by Germany and Japan in the context of their quest for recognition by other major powers – Great Britain, France, Russia, and the United States – and the implications this had internationally. In connection with their material conditions (internal and international) compared to other great powers, this pushed Germany and Japan to embrace policies that were ultimately self-defeating. It led them to see and assess themselves, others, and the international environment in conflicting terms and, faced with the unwillingness of other big powers to accommodate them to the extent they wanted, to overplay their hand, with lethal outcomes as a result.

This article follows two previous articles published in this journal.1It is a case study that focuses on Germany and Japan, and the making of World War II. In the first section, it begins with highlighting the overall relevance of this case study in the context of the analysis of emotions and passions in international politics. In the second section, it shows that both for Germany and Japan a sense of psychological insecurity regarding their international status and their urge to catch up and compensate, put them on a collision course with the great powers of the period. In the third part, the article explains how, in time, this contributed to the fact that Germany and Japan embraced negative and exclusionary political emotions and passions that translated into belligerent policies. In the fourth section, as a way to conclude, the article touches upon how a better understanding of the nature and role of emotions and passions in international affairs can encourage a psychology of peace, and international peace altogether.
Low Levels of Military Threat and High Demand for Increasing Military Spending: The ‘Puzzle of Chinese Students’ Data in the Asian Student Survey of 2008
Authors: OREN EITAN
Published: August 2015

This article examines perceptions of military and defense expenditure as held by Asian students. By using quantitative data from the Asian Student Survey1of 2008 it addresses the following questions: to which areas would Asian students like to see their government allocate more or less resources and, specifically, how supportive of defense and military spending are Asian students. This study finds that data concerning one country have appeared deviant. While designating the strongest will to increase defense and military spending among all countries sampled in the survey, Chinese students from leading universities (N= 800; Pekin and Renmin universities in Beijing; Fudan University and Shanghai Jiao Tong university) also exhibit the lowest levels of perceived military threats. The rest of the paper explores the ‘puzzle’ of Chinese students by generating and testing a null hypothesis. In it, Chinese students' high demand for military spending is associated with an aggressive design, whereby anti-foreign, unilateral, and nationalist sentiments coincide. After refuting the null hypothesis, the paper advances an alternative explanation that links students' inclination with the call to modernize the People's Liberation Army.
Bamboo Shoots and Weak Roots: Organizational Expansion of New Parties in Japan
Authors: HIJINO KEN
Published: August 2015

Recent research claims that local party organizations are essential for new parties seeking organizational stability and national-level electoral success. Yet new parties which emerged in Japan since the 1990s have failed in building nation-wide networks of local organizations. The article asks how these parties sought to expand locally and why their attempts have been largely unsuccessful. It finds evidence that under certain conditions (in urban areas and multi-member districts, or when controlling local chief executive offices and endowed with inherited resources) new parties have been more successful in standing and winning seats in regional elections. Regions with these favorable conditions are few, however, resulting in the overall weakness of the new parties’ local organizations. The study also disconfirms expectations that a party's control of national government should result in their improved representation at the local level. The article contributes to elucidating the incentives and dynamics of building party organizations in terms of local elected offices for newcomer parties in Japan. It hints at similar challenges for entrepreneurial parties with few social roots in other established democracies.
Have Korea and Japan Reconciled? A Focus on the Three Stages of Reconciliation
Authors: CHUN JA-HYUN
Published: August 2015

Previous studies on international reconciliation have focused on the security and economic interests of the countries involved, treating reconciliation as an end-goal rather than an ongoing process. This study divides the process of reconciliation into three stages. ‘Procedural reconciliation’, which refers to the mending of international relations through institutional change, is the most basic. In the ‘material reconciliation’ phase, the perpetrator(s) provides the victim(s) – either at the individual or state level – with economic compensation for inflicting harm. The third stage, ‘ideational reconciliation’, is reached when the perpetrator acknowledges past wrongdoings and when civil and cultural exchanges are carried out smoothly.

This study delves into the relations between South Korea and Japan. Even though reconciliation between South Korea and Japan is vital to achieve stable peace in Northeast Asia, the topic has not received sufficient scholarly attention. Former studies have focused on bilateral relations, but few have discussed the two countries' path towards reconciliation. In this study, readers will find an in-depth analysis of the ties between South Korea and Japan from an international reconciliation perspective, one which will help them understand how the two nations have worked towards understanding and how much they have achieved to date. The study also suggests a roadmap to reach the final stage of reconciliation and identifies the policy changes needed to get there.
Molecular characterization of winter durum wheat (Triticum durum) based on a genotyping-by-sequencing approach
Authors: Sieber Alisa-Naomi , Longin C. Friedrich H. , Würschum Tobias
Published: August 2015

Durum wheat (Triticum durum) is predominantly grown as spring type and depending on the production area autumn or spring sowing is used. For the durum production in Austria and Germany, autumn sowing has several advantages, such as yield increase and stability, but this requires the selection for winter hardiness including a good frost tolerance. The aim of this study was to support breeding of winter durum and to facilitate genomic approaches by molecularly characterizing a panel of 170 diverse winter and 14 spring durum lines employing a genotyping-by-sequencing approach. We obtained an unprecedentedly high number of 30,611 polymorphic markers covering the entire genome. The principal coordinate analysis and the cluster analysis revealed the absence of a major population structure but a tendency of lines to group according to their country of origin. Linkage disequilibrium was found to decay within a short distance of approximately 2–5 cM and also showed variable patterns along chromosomes. In summary, our results can assist breeding of durum wheat and pave the way for genomic approaches towards knowledge-based winter durum breeding.
Asymmetric ice-sheet retreat pattern around northern Scotland revealed by marine geophysical surveys
Authors: Bradwell Tom , Stoker Martyn
Published: August 2015

This study uses marine geophysical data, principally single-beam and high-resolution multibeam echo sounder bathymetry, combined with seismic sub-bottom profiles, and existing Quaternary geological information, to map the glacial geomorphology of a large area of seafloor (∼50,000 km2) on the continental shelf around northern Scotland, from west of Lewis to north of the Orkney Islands. Our new mapping reveals the detailed pattern of submarine glacial landforms, predominantly moraines, relating to ice sheets that covered Scotland and much of the continental shelf during the Late Weichselian glaciation and earlier in the Mid to Late Pleistocene. The reconstructed retreat pattern based on geomorphological evidence highlights the large number of different retreat stages and the asymmetric, non-uniform evolution of this ice sheet sector during Late Weichselian deglaciation. Time-equivalent ice-front reconstructions show that marine sectors of the ice sheet, such as the Minch, changed their geometry significantly, perhaps rapidly; whilst other sectors remained relatively unchanged and stable. We suggest that this behaviour, governed principally by bed topography/bathymetry and ice dynamics, led to reorganisation of the Late Weichselian ice sheet as it retreated back to two main ice centres: one in Western Scotland and the other over Orkney and Shetland. This retreat pattern suggests relatively early deglaciation of NW Lewis (ca. 25 ka BP) and the mountains of far NW Scotland – the latter possibly forming a substantial ice-free land corridor. Our reconstructions differ from most previous syntheses, but are strongly supported by the independently-mapped offshore Quaternary succession and key onshore dating constraints.
Nachsorge von Herzinfarktpatienten in der Hausarztpraxis
Authors: Bischof Tobias R. , Kurz David J.
Published: August 2015

Zusammenfassung. Patienten nach Myokardinfarkt haben ein erhöhtes Risiko für kardiale Ereignisse wie Herzinsuffizienz, Rezidivinfarkt, Rhythmusstörungen, Hirnschlag oder plötzlichen Herztod. In der Nachsorge muss deshalb den potenziellen Komplikationen als auch den anhaltenden Risiken eine besondere Beachtung geschenkt werden. Dazu gehört eine frühe Risikostratifizierung des Patienten. Die medikamentöse Sekundärprophylaxe nach einem Myokardinfarkt beinhaltet in der Regel eine doppelte Thrombozytenhemmung für zwölf Monate, ein Statin, einen ACE-Hemmer und häufig auch einen Betablocker. Bei jedem Patienten sind Lebensstiländerungen (Nikotinabstinenz, regelmässige körperliche Aktivität und Diätanpassungen) indiziert. Zudem müssen Patienten bezüglich der Erkennung von und dem richtigen Verhalten bei Neuauftreten oder Änderung der kardialen Symptomatik informiert sein.
Notfälle in der Ophthalmologie
Authors: Töteberg-Harms Marc , Eisenack Johannes , Funk Jens
Published: August 2015

Zusammenfassung. Der akute Visusverlust, ein schmerzendes oder ein rotes Auge sind typische Leitsymptome einer ophthalmologischen Notfallvorstellung. Bereits eine gründliche Anamnese bezüglich Art, Dauer und Lokalisation der Beschwerden liefert erste wichtige Hinweise auf die Ätiologie der Erkrankung. Mit einfachen diagnostischen Hilfsmitteln kann die Differenzialdiagnose auch durch den Nicht-Ophthalmologen weiter eingegrenzt werden. Aus dieser Verdachtsdiagnose ergibt sich die Dringlichkeit, mit der der Patient an einen Ophthalmologen verwiesen werden muss.
Micro-Heterogeneity of Flow in a Mouse Model of Chronic Cerebral Hypoperfusion Revealed by Longitudinal Doppler Optical Coherence Tomography and Angiography
Authors: Srinivasan Vivek J , Yu Esther , Radhakrishnan Harsha , Can Anil , Climov Mihail , Leahy Conor , Ayata Cenk , Eikermann-Haerter Katharina
Published: August 2015

Although microvascular dysfunction accompanies cognitive decline in aging, vascular dementia, and Alzheimer's disease, tools to study microvasculature longitudinally in vivo are lacking. Here, we use Doppler optical coherence tomography (OCT) and angiography for noninvasive, longitudinal imaging of mice with chronic cerebral hypoperfusion for up to 1 month. In particular, we optimized the OCT angiography method to selectively image red blood cell (RBC)-perfused capillaries, leading to a novel way of assessing capillary supply heterogeneity in vivo. After bilateral common carotid artery stenosis (BCAS), cortical blood flow measured by Doppler OCT dropped to half of baseline throughout the imaged tissue acutely. Microscopic imaging of the capillary bed with OCT angiography further revealed local heterogeneities in cortical flow supply during hypoperfusion. The number of RBC-perfused capillaries decreased, leading to increased oxygen diffusion distances in the days immediately after BCAS. Linear regression showed that RBC-perfused capillary density declined by 0.3% for a drop in flow of 1 mL/100 g per minute, and decreases in RBC-perfused capillary density as high as 25% were observed. Taken together, these results demonstrate the existence of local supply heterogeneity at the capillary level even at nonischemic global flow levels, and demonstrate a novel imaging method to assess this heterogeneity.
Comparative Assessment of Parametric Neuroreceptor Mapping Approaches Based on the Simplified Reference Tissue Model Using [11C]ABP688 PET
Authors: Seo Seongho , Kim Su J , Kim Yu K , Lee Jee-Young , Jeong Jae M , Lee Dong S , Lee Jae S
Published: August 2015

In recent years, several linearized model approaches for fast and reliable parametric neuroreceptor mapping based on dynamic nuclear imaging have been developed from the simplified reference tissue model (SRTM) equation. All the methods share the basic SRTM assumptions, but use different schemes to alleviate the effect of noise in dynamic-image voxels. Thus, this study aimed to compare those approaches in terms of their performance in parametric image generation. We used the basis function method and MRTM2 (multilinear reference tissue model with two parameters), which require a division process to obtain the distribution volume ratio (DVR). In addition, a linear model with the DVR as a model parameter (multilinear SRTM) was used in two forms: one based on linear least squares and the other based on extension of total least squares (TLS). Assessment using simulated and actual dynamic [11C]ABP688 positron emission tomography data revealed their equivalence with the SRTM, except for different noise susceptibilities. In the DVR image production, the two multilinear SRTM approaches achieved better image quality and regional compatibility with the SRTM than the others, with slightly better performance in the TLS-based method.
RETRACTED ARTICLE: High-rate aluminium yolk-shell nanoparticle anode for Li-ion battery with long cycle life and ultrahigh capacity
Authors: Li Sa , Niu Junjie , Zhao Yu Cheng , So Kang Pyo , Wang Chao , Wang Chang An , Li Ju
Published: August 2015

Alloy-type anodes such as silicon and tin are gaining popularity in rechargeable Li-ion batteries, but their rate/cycling capabilities should be improved. Here by making yolk-shell nanocomposite of aluminium core (30 nm in diameter) and TiO2 shell (∼3 nm in thickness), with a tunable interspace, we achieve 10 C charge/discharge rate with reversible capacity exceeding 650 mAh g−1 after 500 cycles, with a 3 mg cm−2 loading. At 1 C, the capacity is approximately 1,200 mAh g−1 after 500 cycles. Our one-pot synthesis route is simple and industrially scalable. This result may reverse the lagging status of aluminium among high-theoretical-capacity anodes.
Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke
Authors: Kim Gab Seok , Yang Li , Zhang Guoqi , Zhao Honggang , Selim Magdy , McCullough Louise D. , Kluk Michael J. , Sanchez Teresa
Published: August 2015

The use and effectiveness of current stroke reperfusion therapies are limited by the complications of reperfusion injury, which include increased cerebrovascular permeability and haemorrhagic transformation. Sphingosine-1-phosphate (S1P) is emerging as a potent modulator of vascular integrity via its receptors (S1PR). By using genetic approaches and a S1PR2 antagonist (JTE013), here we show that S1PR2 plays a critical role in the induction of cerebrovascular permeability, development of intracerebral haemorrhage and neurovascular injury in experimental stroke. In addition, inhibition of S1PR2 results in decreased matrix metalloproteinase (MMP)-9 activity in vivo and lower gelatinase activity in cerebral microvessels. S1PR2 immunopositivity is detected only in the ischemic microvessels of wild-type mice and in the cerebrovascular endothelium of human brain autopsy samples. In vitro, S1PR2 potently regulates the responses of the brain endothelium to ischaemic and inflammatory injury. Therapeutic targeting of this novel pathway could have important translational relevance to stroke patients.
Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements
Authors: Morley Thomas S. , Xia Jonathan Y. , Scherer Philipp E.
Published: August 2015

Dysfunctional adipose tissue represents a hallmark of type 2 diabetes and systemic insulin resistance, characterized by fibrotic deposition of collagens and increased immune cell infiltration within the depots. Here we generate an inducible model of loss of function of the protein phosphatase and tensin homologue (PTEN), a phosphatase critically involved in turning off the insulin signal transduction cascade, to assess the role of enhanced insulin signalling specifically in mature adipocytes. These mice gain more weight on chow diet and short-term as well as long-term high-fat diet exposure. Despite the increase in weight, they retain enhanced insulin sensitivity, show improvements in oral glucose tolerance tests, display reduced adipose tissue inflammation and maintain elevated adiponectin levels. These improvements also lead to reduced hepatic steatosis and enhanced hepatic insulin sensitivity. Prolonging insulin action selectively in the mature adipocyte is therefore sufficient to maintain normal systemic metabolic homeostasis.
Assessing the contribution of interferon antagonism to the virulence of West African Ebola viruses
Authors: Dunham Eric C. , Banadyga Logan , Groseth Allison , Chiramel Abhilash I. , Best Sonja M. , Ebihara Hideki , Feldmann Heinz , Hoenen Thomas
Published: August 2015

The current Ebola virus (EBOV) outbreak in West Africa is unprecedented in terms of both its size and duration, and there has been speculation and concern regarding the potential for EBOV to increase in virulence as a result of its prolonged circulation in humans. Here we investigate the relative potency of the interferon (IFN) inhibitors encoded by EBOVs from West Africa, since an important EBOV virulence factor is inhibition of the antiviral IFN response. Based on this work we show that, in terms of IFN antagonism, the West African viruses display no discernible differences from the prototype Mayinga isolate, which corroborates epidemiological data suggesting these viruses show no increased virulence compared with those from previous outbreaks. This finding has important implications for public health decisions, since it does not provide experimental support for theoretical claims that EBOV might gain increased virulence due to the extensive human-to-human transmission in the on-going outbreak.
The effect of SUV discretization in quantitative FDG-PET Radiomics: the need for standardized methodology in tumor texture analysis
Authors: Leijenaar Ralph T.H. , Nalbantov Georgi , Carvalho Sara , van Elmpt Wouter J.C. , Troost Esther G.C. , Boellaard Ronald , Aerts Hugo J.W.L , Gillies Robert J. , Lambin Philippe
Published: August 2015

FDG-PET-derived textural features describing intra-tumor heterogeneity are increasingly investigated as imaging biomarkers. As part of the process of quantifying heterogeneity, image intensities (SUVs) are typically resampled into a reduced number of discrete bins. We focused on the implications of the manner in which this discretization is implemented. Two methods were evaluated: (1) RD, dividing the SUV range into D equally spaced bins, where the intensity resolution (i.e. bin size) varies per image; and (2) RB, maintaining a constant intensity resolution B. Clinical feasibility was assessed on 35 lung cancer patients, imaged before and in the second week of radiotherapy. Forty-four textural features were determined for different D and B for both imaging time points. Feature values depended on the intensity resolution and out of both assessed methods, RB was shown to allow for a meaningful inter- and intra-patient comparison of feature values. Overall, patients ranked differently according to feature values–which was used as a surrogate for textural feature interpretation–between both discretization methods. Our study shows that the manner of SUV discretization has a crucial effect on the resulting textural features and the interpretation thereof, emphasizing the importance of standardized methodology in tumor texture analysis.
Barnidipine or Lercanidipine on Echocardiographic Parameters in Hypertensive, Type 2 Diabetics with Left Ventricular Hypertrophy: A Randomized Clinical Trial
Authors: Derosa Giuseppe , Mugellini Amedeo , Querci Fabrizio , Franzetti Ivano , Maria Pesce Rosa , D’Angelo Angela , Maffioli Pamela
Published: August 2015

The aim of this study was to evaluate the effects of lercanidipine or barnidipine on echocardiographic parameters, in hypertensive, type 2 diabetics with left ventricular hypertrophy. One hundred and forty-four patients were randomized to lercanidipine, 20 mg/day, or barnidipine, 20 mg/day, in addition to losartan, 100 mg/day, for 6 months. We evaluated: blood pressure, fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), lipid profile, creatinine, estimated glomerular filtration rate (eGFR), sodium, potassium and acid uric. Echocardiography was performed at baseline and after 6 months. Both lercanidipine and barnidipine decreased blood pressure. Left ventricular mass index was reduced to a greater extent with barnidipine + losartan. Interventricular septal thickness in diastole was reduced by barnidipine + losartan. Posterior wall thickness in diastole was decreased by both treatments, even if barnidipine + losartan were more effective. Ratio of peak early diastolic filling velocity to peak filling velocity at atrial contraction was increased by barnidipine + losartan, but not by lercanidipine + losartan. Finally, isovolumetric relaxation and time and left atrial volume index were reduced by barnidipine + losartan, while lercanidipine + losartan did not affect them. In conclusion, barnidipine + losartan provided a greater improvement of echocardiographic parameters compared to lercanidipine + losartan.
Regulation of PLCβ2 by the electrostatic and mechanical properties of lipid bilayers
Authors: Arduin Alessia , Gaffney Piers R. J. , Ces Oscar
Published: August 2015

Phosphoinositide-specific phospholipase C (PLC) is an important family of enzymes constituting a junction between phosphoinositide lipid signaling and the trans-membrane signal transduction processes that are crucial to many living cells. However, the regulatory mechanism of PLC is not yet understood in detail. To address this issue, activity studies were carried out using lipid vesicles in a model system that was specifically designed to study protein-protein and lipid-protein interactions in concert. Evidence was found for a direct interaction between PLC and the GTPases that mediate phospholipase activation. Furthermore, for the first time, the relationships between PLC activity and substrate presentation in lipid vesicles of various sizes, as well as lipid composition and membrane mechanical properties, were analyzed. PLC activity was found to depend upon the electrostatic potential and the stored curvature elastic stress of the lipid membranes.