bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementasi Evaluasi Modul Kurikulum Merdeka Sekolah Penggerak Terhadap Peserta Didik SMA Perintis 1 Bandar Lampung
Authors: Aransyah Ade , Herpratiwi Herpratiwi , Adha Muhammad Mona , Nurwahidin Muhammad , Yuliati Dwi
Published: January 2023

Program sekolah ini dirancang untuk mendukung setiap sekolah dalam menciptakan generasi pembelajar sepanjang hayat yang berkepribadian sebagai siswa pelajar Pancasila.Komitmen yang kuat, kesungguhan dan implementasi nyata dari semua pihak, sehingga profil pelajar pancasila dapat tertanam pada peserta didik. Pada pelaksanaannya dewan guru sebagai fasilitator merasakan kebingungan dalam merancang pelaksanaan pembelajaran disekolah terutama pada penyusunan perangkat ajar yang berupa modul ajar pada kurikulum merdeka. Penelitian ini bertujuan untuk mengetahui implementasi evaluasi modul kurikulum merdeka sekolah penggerak terhadap peserta didik sma perintis 1 bandar lampung. Penelitian ini adalah penelitian pengembangan dengan menggunakan pendekatan ADDIE (Analisis, Desain, Development, Implementasi dan Evaluasi. populasi pada penelitian ini adalah seluruh peserta didik Kelas XII SMA Perintis 1 Bandar Lampung yang berjumlah 30 peserta didik dengan menggunakan teknik random sampling yang mengikuti mata pelajaran PKn, pemilihan mata pelajaran Pkn ditentukan mengingat waktu yang terbatas. Penelitian ini menggunakan 20 item insturmen dengan hasil reabilitas instrument 0,847 yang memiliki alternative reabilitas instrument sangat tinggi. Guna mengetahui ada pengaruh atau tidaknya Implementasi pelatihan modul merdeka belajar terhadap peserta didik SMA Perintis 1 Bandar Lampung, dilakukan uji hipotesis N-Gain dengan mengukur hasil prestest dan posttest nilai ujian Pkn Peserta didik
The miR125b as Biomarkers in The Early Diagnosis of Bladder Cancer
Authors: Canatan Duran , Yilmaz Ozlem , Sonmez Yonca , Baykara Mehmet , Savas Murat , Coskun Hasan Senol , Goksu Sema Sezgin , Aktekin Mehmet Rifki
Published: January 2023

Objective: Bladder cancer (BCa) is the fifth most common cancer and the second most common urinary tract cancer in worldwide. BCa accounts for 3% of all cancers and is particularly common in developed countries. Material and methods: Eighteen of the 20 patients included in the study were male, 2 were female, mean age was 65.1±12.1(range:37-75) years. The control group consisted of 19 male one female, mean age was 60.3±11.2 ( range:40-70) years. A total of seven miRNAs, let-7c, miR-155 , miR-125b, miR-141 miR-145, miR 181 and miR 192 were evaluated in two groups. Results: MiRNAs of bladder cancer patients and healthy individuals were compared according to endogenous miR 181 and miR 192 Delta CT values, miR125b values of bladder cancer cases were found to be significantly higher than healthy controls.(p=0.021) In our study, miR125b, which we found specific and sensitive in endogenous controls, was compatible with studies in the literature. As conclusion, we emphasize that mir125b can be used as a predictor in bladder cancer compared with the literature.
Novel GLRA1 Variants Causing Neonatal Arthrogryposis and Developmental Delay in Three Unrelated Cases. Early Signs of Autosomal Dominant Hyperekplexia
Authors: Escobar Luis F , Estes Caroline , Reynoso Francis J , Underhill Hunter R , Samuelson Audrey
Published: January 2023

Hereditary hyperekplexia (HPX) is an inherited neuronal disorder characterized by exaggerated startle responses and stiffness to unexpected stimuli. In the newborn period, the phenotype may present as decreased range of motion of all joints, neonatal arthrogryposis or generalized neonatal hypertonia [1]. HPX is associated with three main genes: GLRA1, GLRB, and SLC6A5 [2]. We report three unrelated families with variants in the GLRA1 gene that expand the understanding of the clinical presentation of affected individuals with GLRA1 variants. No variants observed have been previously reported, two of them are familial and one a de-novo change. One of the families presents three generations of affected individuals with neonatal joint contractures. All three probands in this report present with significant developmental delay, speech delay, feeding difficulties, and motor delay. Hearing loss was seen in one of the patients. All patients appear to present with central hypotonia and two of them present with central hypotonia and peripheral hypertonia with hyperreflexia. Currently it has been suggested that GLRA1 dysfunction results in failure of inhibition of potent neurotransmitters in the central nervous system [3]. This may explain the intrauterine signs and perinatal presentation of neuromuscular dysfunction in the reported patients. We believe that the information presented here helps to understand the natural history of hyperekplexia. Early recognition of this rare disorder is important due to the high risk of sudden infant death in children due to apnea and the potential to implement rescue treatments. Based on these cases, patients with genetic variants in the GLRA1 gene may present with congenital arthrogryposis that improves with time and results in a milder form of distal joint contractures in adulthood. Patients with hyperekplexia may have a better prognosis than other forms of arthrogryposis and we suggest that GLRA1 gene testing should be included in neonatal arthrogryposis panels.
The Importance of Microrna21 as Biomarker in Hepatocellular Carcinoma
Authors: Canatan Duran , Sonmez Yonca , Yilmaz Ozlem , Coskun Hasan Senol , Goksu Sema Sezgin , Ucar Selda , Yildirim Bulent , Aktekin Mehmet Rifki
Published: January 2023

Objective: Hepatocellular carcinoma (HCC) is the fifth most common cancer and the second leading cause of cancer- related deaths worldwide.The diagnosis of HCC patients remains difficult, especially early in the development of the disease, and yet early and accurate diagnosis of HCC patients is vital in order to improve prognosis. Promising biomarkers for diagnosis of HCC have been successfully identifiedin several studies. MicroRNA-21 is one of the oncogenic miRNAs which may be a potential diagnostic biomarker for HCC.Our aim in the study was to investigate microRNAs as a biomarker in HCC and to compare the most unique MiR-21 in the literature as a biomarker and prognostic factor. Materials and Methods: Ten patients diagnosed with HCC and ten healthy individuals of the same age and gender were selected as the control group. Six miRNAs (Let-7c, miR-1, miR-21, miR-29, miR-34, miR-335) selected and MiR 181 and miR 192 used as the endogenous control group. Results: MiR21 was upregulated and statistically important compared with the endogenous control miR181(p=0.041). In the ROC analysis curve, AUC was significantly high for Delta181CT miR-21 (0.778). The sensitivity and specificity values of Delta181CT miR-21 with an optimal cut-off value of -3.508564949 were 77.8% and 90.0%. respectively. None of six miRNA statistically important compared with the endogenous control miR192. Conclusion: MiR21 is important for determining as biomarkers at diagnosis of HCC.
Is There a Place for an Individual Approach to Late Preterm Newborns According to Gestational Age?
Authors: Simão-Raimundo Diana , Arruda Augusta , Ormonde Mariana , Stokreef Sarah , Dâmaso Catarina , Furtado-Lima Ana
Published: January 2023

Introduction: Late preterm infants (LPT) are at high risk for perinatal acute morbidity and mortality. This risk seems to be lower with increasing gestational age (GA). We aim to discuss if an individual approach to the LPT according to GA is justified. Materials and Methods: A secondary analysis of a retrospective study on antenatal corticosteroids in LPT birth was performed. Singleton, nonanomalous, delivered at 34–36 weeks infants born between January 1 2012, and December 31 2017 were included and classified into three groups according to GA at birth: 34+0 to 34+6 weeks; 35+0 to 35+6; 36+0 to 36+6. Primary outcomes included neonatal morbidity at birth and neonatal respiratory morbidity in the first 72 hours. Maternal demographic and obstetric data were analyzed as possible confounders. Results: From a total of 390 LPT, 58.4% were born at 36 weeks, 24.9% at 35 and 16.7% at 34. Respiratory morbidity was 7 times higher in 34w than in 36w neonates. Comparing with 36w, 34w neonates reported 2.6 times more jaundice and 9 times more NICU admission. Neonates born at 34 weeks were more likely to present, with statistical significance: need of oxygen supplementation at birth and in the first 72 hours of life; need for non-invasive respiratory support; RDS of newborn; TTN; NICU admission; prolonged hospital stay for more than seven days; need for nutrition through nasogastric tube; jaundice with need for phototherapy; sepsis evaluation; treatment with antibiotics; hypoglycemia. Respiratory and non-respiratory outcomes decreased with increasing GA. Discussion: These findings suggest that one week makes a difference in neonatal outcomes. Whenever possible efforts should be made to postpone preterm delivery. A discussion about individual approach to LPT according to GA should be raised. GA-specific guidelines could be justified to anticipate and prevent morbidity in perinatal life.
Prevalence of Neonatal Resuscitation in Yaoundé-Cameroon
Authors: Claude-Audrey MEGUIEZE , Eric NSEME ETOUCKEY , Isabelle MEKONE NKWELE , Félicité NGUEFACK , Jeannette EPEE  NGOUE , Daniel KAGO , Cindy Brenda NGASSAM , Rose Andréa YAKA , Ivan EBOUTOU , Jules Thierry ELONG , Paul KOKI NDOMBO
Published: January 2023

Aim: To determine the prevalence of neonatal resuscitation in two hospitals of Yaoundé in Cameroon. Methods: A retrospective cross-sectional study was conducted for seven months ranging from 18 October 2021 to 18 May 2022 in two hospitals of Yaoundé. Admission files of new-borns who benefited from neonatal resuscitation at birth from the year 2015 to 2020 were included. We recorded the socio demographic variables of the children’s mothers (age, level of education et region of origin) and the clinical characteristics of new-borns (gestational age, gender, birth weight, Apgar scores) in an operating sheet. The results were analysed using IBM SPSS.23.0 software and the data expressed as frequencies percentages, and means. Results: The main maternal age ranged between 25 to 30 years (28,9%). The mean age being 29.9 ± 5.8 years with extremes values of 15 and 42 years. Concerning the level of education, most had a secondary level (37.8%). There was a predominance of mothers from the Center region (38.5%). Most of the newborns were born at term (61.6%). The mean gestational age at delivery was 36.7 ± 3.6 WA with extreme values of 25 and 46 WA. The male gender was the most represented with 55% of the cases giving a sex ratio of 1.25. More than half of these babies had a birth weight between 2500 et 4000 grams (62.4%). The mean birth weight was 2748.4 ± 794.3 grams with extreme values of 800 and 5600 grams. The global hospital prevalence of neonatal resuscitation was 3.5%. Conclusion: Term new-borns of male gender were most affected. The overall hospital prevalence and prevalence per health facility was low.
The Role of Mitochondria in Cartilage Degenerative Disorders
Authors: Nalapko Yuriy , Lakey Jonathan RT , Adalsteinsson Orn , Klokol Dmytro , Skutella Thomas , Pan Shing Yi , Wellington Augusta , Wong Michelle BF , Chan Michael KS , Cox Desiree
Published: January 2023

Mitochondria are major organelles that produce energy for cellular metabolism and are vital to proper cell functioning. Metabolic dysregulation is a critical contributing factor to the initiation and development of degenerative and autoimmune diseases, thus is present in cartilage disorders such as osteoarthritis and rheumatoid arthritis. Mitochondrial dysfunction in cartilage diseases is especially interesting because it may present a promising therapeutic and anti-ageing target. By understanding the mechanism of mitochondrial dysfunction, we can aim to upregulate the role of mitochondria in treating cartilage diseases. In this review, we look at the role of mitochondrial dysfunction in degenerative cartilage diseases and mitochondria as tools in the treatment of osteoarthritis and rheumatoid arthritis.
Factors Related to Farmers’ Acceptance of Improved Technologies: A Case Study of Small-scale Sugar Cane Farmers in Kakamega County, Kenya.
Authors: Thuo Caroline M , Ombati Justus M , Nkurumwa Agnes O
Published: January 2023

Improvement of agricultural technologies has been a global focus, aimed at enhancing agricultural productivity for economic growth and improved livelihood. Through research, many agricultural technologies, loaded with potential benefits have been produced but their acceptance by the intended users has been a global challenge. This calls for need to develop effective mechanism to enhance technology acceptance so that their potential benefits may be realised. This study focused on these phenomena through establishment of various factors related to acceptance of improved sugar cane varieties among small-scale sugar cane farmers in Kakamega County. Understanding of these factors was critical, as it would pin point critical conditions that would facillitate wider acceptance of improved technologies by the targeted users. The study was built on Unified Theory of Acceptance and Use of Technology (UTAUT); and the theory of Diffusion of Innovations (DOI). A Cross-Sectional Survey research design was used. The target population was 137,355 sugar cane farmers from Kakamega County, from which a sample of 384 farmers was randomly selected. Questionnaires were used to collect data. Statistical analysis was done using chi-square at 0.05 significance level. The study findings established significant relationships between gender, age, education, land ownership, experience in farming, source of income, sugar cane varietal attributes, variety choice, seed sources, availability of advisory services and marketing of sugar cane, with farmers’ acceptance of improved varieties. Addressing these factors is of great importance to technology developers and promoters as they would facilitate acceptance of the improved technologies produced by farmers. The study recommended extension service providers and sugar millers to provide farmers with adequate information on improved sugar cane varieties, required facilitating resources and supportive services in effort to enhance production of these varieties by farmers. The study has also contributed valuable information to the existing literature in agricultural extension.
An Assessment of the Factors Responsible for the Extent of Deforestation in Mapfungautsi Forest, Zimbabwe
Authors: Nyahwai Rodrick , Masere Tirivashe Phillip , Zhou Neil Mandinyenya
Published: January 2023

This study was conducted in Mapfungautsi forest to determine the extent of deforestation from the year 2000 (when no deforestation was detected by satellite imagery) up to 2020, as well as to gather perspectives from members of communities around the forest, on factors responsible for deforestation. A mixed method approach in the form of remote sensing techniques, questionnaires and key informant interviews was used to gather data. Findings indicated the extent of deforestation to be 4254ha (5%) and 10632ha (14%) after the first decade (2000 – 2010) and second decade (2000 – 2020) respectively. Of the cleared forest, the most affected vegetation cover type was the wooded grassland (84%) followed by bushland (31%) and wooded land (10%) after the 20-year period. Respondents identified political gain, expansion of jurisdictions of chiefs and population pressure as the social factors most responsible for accelerated deforestation in Mapfungautsi. Conversely, the identified economic factors mainly contributing to deforestation were agriculture, timber and firewood poaching. The study concluded that agriculture was the single most impactful factor responsible for deforestation as the main social factors (political gain and expansion of chieftaincy) worked in combination to invade and clear protected forests for settlement and agriculture (which is also the main livelihood source of local people). Consequently, any control measures to arrest deforestation in Mapfungautsi and any other protected forests for that matter, will require serious buy-in and will power from political and traditional leaders and other stakeholders like farmers and community members.
The Use of a Suspension of Functionalized Gadolinium Oxide Nanoparticles for Photocatalytic Applications
Authors: C Massard , K.O Awitor
Published: January 2023

Photo-degradation of Rhodamine B (RhB) in aqueous solution was use as a probe to assess the photocatalytic activity of Gadolinium oxide (Gd2 O3 ) nanoparticles in suspension under UV irradiation. The nanoparticles in suspension were prepared by a polyol method using gadolinium chloride hexahydrate (Gd2 Cl6 .6H2 O) and diethylene glycol (DEG) as starting precursors. The physico-chemical properties of the elaborated suspension are analyzed using X-ray diffraction (XRD), ultraviolet visible (UV-vis) and infrared (FTIR) spectroscopies, transmission electron microscopy (TEM) and viscosimetry. The Gd2 O3 nanoparticles in suspension were used as photocatalyst for the degradation of Rhodamine B (RhB) dye under irradiation with UV light. The results of the kinetic studies showed that the photodegradation reactions were followed by a pseudo first order reaction rate law over the first 30 minutes of monitoring. The elaborated Gd2 O3 nanoparticles suspension showed a great efficiency in the photocatalytic test without any addition of a co-catalyst, thus limiting the complexity of the further decontamination process of waste water.
Hypoglycemia In Non-Diabetic Patient: Report of Two Cases of Insulinoma
Authors: Castellón-De la Rosa Evis Adriana , Jiménez-Arcia Luisa Fernanda , Pérez-Calvo Christian , Cano-Peñaloza Raquel , Crespo-Vizcaino Estiven , Brito-Jacome Carlos José , Parra-Lizarazo Johana Maria , Saavedra-Ruiz Jorge Andrés , Marenco-Salazar Juan David
Published: January 2023

Background: Insulinoma is a B-cell tumor of the islets of the pancreas with an incidence of 4 per 1 million people per year, which produces excess insulin and can cause symptoms related to hypoglycemia at the level of the central nervous system or symptoms related to excess release of catecholamines. The presence of hypoglycemia, elevated insulin, proinsulin, and c-peptide levels suggest endogenous hyperinsulinism, which together with imaging findings suggestive of neuroendocrine tumor, allow establishing the diagnostic impression of Insulinoma. Case Report: Patients with neuroglycopenic symptoms, biochemical profile of hypoglycemia, endogenous hyperinsulinemia and radiological finding compatible with insulinoma are reported, who were treated by surgical resection of the tumor, with complete resolution of the initial symptoms. Conclusion: The clinical presentation, diagnosis and treatment of insulinoma represents a clinical challenge, since it is a rare pathology and the delay in diagnosis can have catastrophic consequences for the patient such as permanent brain damage and death.
Tecnologia da informação para redução do uso irracional de inibidores da Bomba de Prótons – Revisão narrativa
Authors: Cavalcante Rafaelle Marques , Augusto Kristopherson Lustosa , Kubrusly Marcos
Published: January 2023

Introdução: Os inibidores da bomba de prótons (IBPs) foram clinicamente introduzidos em 1989 e mostraram-se eficazes para o tratamento de ampla gama de patologias atribuíveis ao ácido gástrico. Com o tempo tornaram-se vítimas do seu próprio sucesso, sendo prescritas em excesso, em altas doses e períodos maiores que o indicado. Por outro lado, a tecnologia da informação (TI) passou a ser utilizada para auxiliar o processo de aprendizagem, desempenhando um papel cada vez mais importante na educação médica. Objetivo: Sendo a TI um método de uso tão versátil dentro do campo da medicina e educação em saúde, seria esse recurso capaz de reduzir, através de informação e educação de médicos e pacientes, o uso indiscriminado dos IBPs? Método: Realizamos uma revisão narrativa, usando MEDLINE, Bases de dados PubMed, SciELO, LILACS, SCOPUS e Google acadêmico para extrair artigos. Pesquisamos a literatura dos últimos 10 anos, sendo termos DeCS/MeSH usados ​​na busca “proton pump inhibitor”, “medical education”, “ gastroenterology” e “internato e residência”, além de termos como “prescription”, “ulcer”, “free open acces medical education”, “FOAM”, FOAMed”, “information technology”, “medical apps”, “aplicativos”, “inibidores da bomba de prótons”. Resultado: Após pesquisa realizada, foram encontrados artigos com diferentes ferramentas educacionais, mas apenas dois (PINCER e FORTA-EPI) utilizaram TI para prescrição mais racional de medicações. Conclusão: Observou-se escassez de publicações relacionando tecnologia da informação e gastroenterologia, bem como uso de inibidores da bomba de prótons, indicando a necessidade de estudos que de fato comprovam que haveria redução de prescrições sem indicação dos IBPS e validação de aplicativos para esse fim. Diante do apresentado, pôde-se concluir que intervenções de feedback e orientações educacionais têm uma possibilidade de orientar de forma positiva a conduta médica na prática clínica. Dessa forma, propomos o desenvolvimento de aplicativo para facilitar essa difícil área de intervenção.
Instrumentos de mensuração da qualidade de vida relacionados à saúde bucal
Authors: Carneiro Ítalo Rios , Santos Pedro Victor Duarte Maciel dos , Silva Ivana Conceição Oliveira da , Souza Andressa Lima de , Barreto Juliana Albuquerque Reis , Cerqueira Filipe da Silva , Almeida Igor Ferreira Borba de
Published: January 2023

Introdução: Qualidade de vida relacionada à saúde bucal (QVRSB) foi conceituada como o impacto das doenças bucais sobre aspectos da vida cotidiana que são importantes para as pessoas, com os impactos sendo de magnitude suficiente, quer em termos de frequência, gravidade ou duração, para afetar a percepção do indivíduo sobre sua vida em geral. Objetivo: Reunir os instrumentos utilizados para mensurar a qualidade de vida relacionados à saúde bucal. Método: Na base de dados Scielo, realizou-se a seleção dos estudos mediante leitura de títulos e resumos, em seguida, lidos na íntegra e foram incluídos àqueles que obedeceram aos critérios de elegibilidade. Por seguinte, foi feito a análise e interpretação dos dados coletados. Resultados: Foram analisados artigos na íntegra do ano de 2021 (n: 69) na base de dados Scielo. Para a elaboração da tabela foram usados 28 artigos científicos (40,58%), tipo de estudo que mais prevaleceu foi transversal (39,28%). Em relação aos instrumentos em específico que o instrumento mais explorado nas análises de QV relacionada a odontologia foi o OHIP-14 (34,48%): Conclusão: Diante do exposto, observa-se que o conhecimento da QV é de suma importância para o CD, os instrumentos que mensuram a QV são ferramentas importantes para fomentar políticas públicas além de mostrar a realidade exposta pelo próprio paciente nos questionários.
Análise de mercado de sistemas de energia solar fotovoltaica com ênfase na área rural brasileira
Authors: Mariano Daniele Cristina Lopes , Calça Marcus Vinicius Contes , Caneppele Fernando de Lima , Carvalho Silvia Angélica Domingues de
Published: January 2023

A energia solar é uma fonte de eletricidade renovavél que pode ser captada e convertidas por meio de painéis solares, se tornando uma interessante opção para abastecer locais geograficamente isolados. O objetivo deste estudo é realizar uma análise de mercado de sistemas solares fotovoltaicos para uso residencial e comercial, assim como levantar informações sobre a montagem tradicional (fixa) e móvel (rastreamento solar), com ênfase na melhor eficiência energética para uso em áreas rurais remotas no Brasil. Neste sentido, foi analisado o custo estimado e real para a montagem tradicional dos sistemas solares fotovoltaicos dos últimos 10 anos, assim como foi feita uma análise de implantação da montagem móvel em relação ao mercado atual através das metodologias PEST e SWOT. Foi apontado que um sistema solar fotovoltaico móvel com rastreamento solar tende a gerar mais eletricidade que um de montagem fixa,  no entanto, seu custo é maior devido aos dispositivos elétricos necessários para realizar a movimentação. Neste caso, informações mais detalhadas sobre custos não foram encontradas na literatura. Foi apontado também que atualmente a implantação de um sistema solar fotovoltaico (montagem fixa) está em torno de R$ 4,88/Wp para uso residencial e R$ 3,88/Wp para uso comercial, com uma tendência de redução ao longo dos anos. Para futuros estudos propõem-se o levantamento de custos para a implantação de sistemas solares fotovoltaicos com rastreadores solares de eixo único e de duplo-eixo, no intuito de compreender se a melhor eficiência energética gerada é uma vantagem em relação a seu custo de montagem.
Construção e validação de um guia educativo sobre saúde bucal para idosos inseridos na atenção primária à saúde
Authors: Fontany Thayná Almeida Miranda , Farias Solange da Silva , Santos Maiara Laís Fried dos , Paiva Manuela de Almeida , Paiva Matheus de Almeida , Tavares Caroline de Souza , Uchoa Daniel Cavallero Colares , Mitre Antônia Roberta Sampaio , Dias George Alberto da Silva , Dias Biatriz Araújo Cardoso
Published: January 2023

O processo de cuidar e educar em saúde pode ocorrer por meio de instrumentos, dentre eles, as Tecnologias Educacionais; que favorecem participação dos usuários, contribuem para a cidadania e desenvolvem a autonomia. A transição demográfica gerou mudanças no perfil populacional mundial. Assim, o envelhecimento é considerado um processo dinâmico e complexo com mudanças que influem na qualidade de vida do indivíduo. No Brasil, ocorre de maneira rápida e intensa e apesar de ser um aspecto positivo, traz demandas relacionadas à reorganização da Atenção à Saúde no Sistema Único de Saúde. Esse estudo teve como objetivo construir e validar uma tecnologia educacional sobre saúde bucal para idosos inseridos na Atenção Primária a Saúde do município de Belém – Pará. Após aprovação do Comitê de Ética em Pesquisa, foi realizado estudo metodológico em cinco fases: diagnóstico situacional, revisão bibliográfica, construção da tecnologia, validação e revisão. Participaram do estudo, 23 profissionais da área da saúde, 13 de outras áreas e 82 idosos vinculados a Unidade Municipal de Saúde Benguí II para o levantamento do diagnóstico situacional, sendo que destes, 17 participaram da validação. Após a construção do guia, passou por validação de conteúdo, aparência e semântica, respectivamente; e após análise, o guia educativo foi aprovado pelos Índices de Validação correspondentes para cada público-alvo. A tecnologia educacional sobre saúde bucal para idosos, mostrou-se um instrumento válido e adequado para ser distribuído aos profissionais da atenção básica e ao público-alvo, sendo instrumento eficaz para fornecer informações valiosas sobre saúde e, também, age como ponte de diálogo.
Expectativa de consumo com base na aparência de sorvete vegano elaborado a partir do extrato hidrossolúvel da amêndoa da castanha de caju
Authors: Saraiva Matheus Calixto , Reis Dilson Cristino da Costa , Cruz Gizele Almada , Carvalho Juliane Döering Gasparin
Published: January 2023

A procura por alimentos que não possuem matérias-primas de origem animal em sua formulação está em constante crescimento. A razão disto é o número de pessoas que se autodenominam vegetarianas ou veganas, que possuem problemas de saúde ou que optam por dietas restritivas por diversas razões. Problemas relacionados ao consumo de leite, como alergia à proteína e a intolerância à lactose acometem grande parte da população, sendo necessário desenvolver produtos que atendam à necessidade desses consumidores. Com vista na elaboração de produtos análogos ao leite de vaca, diversos estudos estão sendo realizados sobre extratos vegetais. Este estudo teve como objetivo avaliar a expectativa do consumidor sobre a produção de sorvete vegano à base de extrato hidrossolúvel da amêndoa da castanha de caju, a fim de comprovar sua aceitação para uma possível viabilidade de produção. A análise de expectativa de consumo foi realizada por meio de formulário eletrônico com questionário estruturado apresentando duas formulações aos participantes, com diferentes concentrações do extrato solúvel em água, com a amostra A utilizando extrato na proporção de 1:3 e a amostra B a proporção de 1:5. Foi possível obter resultados favoráveis, com índice de aceitação da amostra A de 91,90 % e da amostra B de 76,20 %. Dessa forma, a aceitabilidade visual do sorvete produzido com extrato de amêndoa de castanha de caju evidencia seu potencial na substituição de derivados lácteos, conferindo uma alternativa para pessoas que necessitam ou querem abdicar do leite de origem animal, seja por motivos de saúde ou por opção.
Associação entre a infecção pelo Helicobacter pylori e o risco de desenvolvimento da doença arterial coronariana: uma revisão de escopo
Authors: Santos Trinnye Luizze , Parreira Walquiria da Silva Pedra , Roman Ricardo Ferreira , Brustollin Gustavo , Alves Carlos Eduardo Martins , Durães Ruanner Ronann Marques , Silva Ariane Matoso da , Pereira Lucas França Belfort , Fetzer Maiko Rodrigo , Alves Luciano da Silva
Published: January 2023

A infecção por Helicobacter Pylori (HP) afeta bilhões de pessoas ao redor do mundo, sendo essa bactéria considerada o agente infeccioso mais prevalente nos seres humanos. Nos últimos anos, a literatura tem evidenciado uma possível associação entre essa infecção e o desenvolvimento de doença arterial coronariana (DAC), uma vez que ambas condições são consideradas doenças crônicas, compartilhando entre si de eventos fisiopatológicos semelhantes. O presente estudo objetiva avaliar a associação entre a infecção por HP e o risco de desenvolvimento de DAC. Para essa Revisão de Escopo, realizada através das plataformas PubMed e Cochrane Library entre 2022 e 2012, os descritores eleitos foram ‘’Helicobacter Pylori’’, ‘’Coronary Disease’’ e ‘’Heart’’, associados ao operador exclusivamente ao booleano ‘’AND’’. Os critérios de inclusão consistiram 1) ensaios clínicos, testes controlados e aleatórios, revisões e meta análises, 2) trabalhos acerca da associação entre DAC e HP, 3) estudos que avaliaram a extensão dos danos cardiovasculares em decorrência da infecção por HP e 4) artigos escritos em língua portuguesa, japonesa, inglesa ou em espanhol. Os critérios de exclusão incluíram inadequações ao tema, relatos de casos e estudos com animais, além de textos fora do limite temporal. As evidências encontradas sugeriram que os principais efeitos adversos cardiovasculares relacionados à infecção por HP estavam associados à DAC, a aterosclerose, a hipertensão arterial sistêmica e ao infarto agudo do miocárdio. Métodos de rastreio, avaliações intervencionistas e indicações para a utilização de marcadores laboratoriais, assim como mais análises clínicas acerca dessa interação ainda permanecem como tópicos a serem melhor elucidados.
Microangiopatia trombótica por COVID-19 superposta a doença renal crônica não dialítica: relato de caso
Authors: Oliveira Karla Loureto de , Lima Rafael Siqueira Athayde , Studart Rita Mônica Borges
Published: January 2023

Objetivo: Descrever um caso de microangiopatia trombótica por COVID-19 superposta a DRC não dialítica, que estava sob cuidados médicos da equipe da enfermaria de Nefrologia em um centro de referência no nordeste do Brasil. Metodologia: Estudo do tipo relato de caso no qual apresentamos um caso de MAT com lesão renal grave desencadeada por SARS-CoV-2 em uma paciente com nefropatia crônica prévia, que evoluiu com necessidade de hemodiálise. Resultados: A MAT associada a SARS-CoV-2 parece estar relacionada à ativação descontrolada de uma via alternativa do complemento e à alteração da integridade do endotélio vascular, levando à liberação de citocinas inflamatórias e consequente ativação da cascata de coagulação local. Para melhorar o desfecho desses pacientes, faz-se necessário identificar rapidamente a MAT, ofertar terapia de suporte e, quando aplicável, o tratamento específico de acordo com a fisiopatologia subjacente. Discussão: COVID-19 pode se manifestar como disfunção de múltiplos órgãos, sendo o envolvimento pulmonar o mais comum. A resposta imune exagerada na forma de ativação irrestrita do complemento e tempestade de citocinas podem ser fator chave para a lesão orgânica generalizada. Pode haver hipercoagulabilidade e alta taxa de trombose. Embora a trombose macrovascular seja comum nesses indivíduos, o achado frequente de tromboses microvasculares levanta a possibilidade de microangiopatia trombótica (MAT) como fator contribuinte para as complicações de múltiplos órgãos, incluindo o rim. Conclusão: O manejo da MAT é um desafio e as taxas de sobrevivência estão diretamente relacionadas ao tempo de implementação do tratamento adequado.
Implicações endodônticas em pacientes oncológicos irradiados em cabeça e pescoço: uma revisão integrativa
Authors: Oliveira Thayse Gomes da Silva , Amorim Lucas Estrêla de , Cerqueira Joana Dourado Martins , Porto Edla Carvalho Lima , Nagahama Maria do Carmo Vasquez Fernandes Bastos , Costa Rêuder Nascimento Cerqueira
Published: January 2023

O câncer de cabeça e pescoço é uma doença crônica considerada um problema de saúde pública. Dentre as modalidades terapêuticas, a radioterapia implica em complicações orais e mudanças estruturais no órgão dental, dentre elas, modificações pulpares. Na ocorrência do envolvimento pulpo-periapical, a endodontia atraumática é o tratamento de escolha por ser mais conservadora e por conseguir eliminar a infecção, evitando uma exodontia com potencial risco de osteorradionecrose. Diante disto, o objetivo desse trabalho foi revisar na literatura a conduta do cirurgião-dentista frente ao tratamento endodôntico em pacientes oncológicos irradiados em cabeça e pescoço. Tratou-se de uma revisão integrativa de literatura, com caráter qualitativo e abordagem descritiva, realizada no período de fevereiro a agosto de 2022, no portal da Biblioteca Virtual em Saúde e nas bases de dados Scientific Electronic Library Online e PubMed, com a estratégia de busca “((endodontics AND radiotherapy AND cancer AND treatment) OR (endodontia AND radioterapia AND câncer AND tratamento))”. Os nove estudos incluídos nesta pesquisa abordaram que todos os pacientes irradiados em região de cabeça e pescoço e que necessitavam de tratamento endodôntico para erradicar infecções e/ou prevenir exodontias, deveriam ser tratados obedecendo aos princípios que norteiam a endodontia atraumática e garantindo assim, mínima reação inflamatória nos tecidos. Para isso, o cirurgião-dentista deve ter pleno domínio na técnica endodôntica atraumática, proporcionando um tratamento mais conservador, excelente prognóstico e qualidade de vida aos indivíduos afetados.
Penciptaan Video Seni “Panji Romance”
Authors: Nugroho Didit Prasetyo
Published: January 2023

Kisah Panji merupakan sastra lisan yang bercerita tentang kisah cinta Raden Panji Asmarabangun, seorang putra mahkota Kerajaan Jenggala, dengan Dewi Sekartaji seorang putri Kerajaan Panjalu. Perjalanan romantika kedua tokoh ini tidak berjalan dengan mulus, namun banyak terjadi petualangan dan penyamaran sehingga kisah Panji ini tersebar dengan berbagai macam versi berupa dongeng dan cerita rakyat lainnya. Cerita Panji ditampilkan dalam bentuk karya sastra dan seni pertunjukan. Cerita ini juga muncul dalam beragam versi. Perbedaan versi tersebut secara umum disebabkan oleh kreativitas personal penyadur, kelenturan cerita dalam bentuk tradisi lisan, dan pengadaptasian cerita pada mitos dan legenda di setiap daerah persebarannya. Dari beragam jenis cerita yang dipentaskan oleh berbagai daerah, Malang merupakan salah satu daerah yang memiliki kesenian khas yaitu wayang topeng Malang. Wayang topeng adalahsebuah pertunjukan jenis drama yang mengedepankan aspek tari sebagai sajian utamanya dan dalang sebagai pengatur cerita. Setiap penari memakai topeng yang berbeda sesaui dengan karakter yang dimainkannya.  Kesenian wayang topeng Malang telah menjadi kesenian yang melekat di masyarakat daerah Malang sejak dahulu dan menjadi bagian identitas masyarakat Malang. Dalam penelitian ini, penulis memaparkan bagaimana proses perancangan video seni dengan berdasarkan pada cerita wayang topeng Malang dengan judul “Panji Romance”.
Perluasan Jaringan Pemasaran melalui Kemitraan dengan Marketplace bagi PKL Dampak Relokasi Pemkot Surakarta
Authors: Prameswari Nadia Sigi , Widagdo Pratama Bayu , Sugiarto Eko
Published: January 2023

Pedagang Kaki Lima (PKL) dianggap menimbulkan kesemrawutan Kota Surakarta karena membuat kumuh dan menimbulkan kemacetan. Demi menjaga keindahan kota, para PKL menjadi sasaran relokasi Pemerintah Kota Surakarta. Kondisi tersebut menimbulkan permasalahan baru bagi PKL lantaran kehilangan pelanggan serta rendahnya anemo pengunjung karena sebagian besar masyarakat belum mengetahui keberadaan lapak baru pasca relokasi. Solusi yang dapat ditempuh dari permasalahan tersebut adalah melalui pelatihan inovasi pemasaran dan strategi promosi bagi PKL, meliputi: (1) pelatihan dan pendampingan memfokuskan pada strategi inovasi pemasaran, meliputi: kemitraan dengan marketplace/e-commerce produk kuliner, (2) perancangan alternatif program promosi sesuai dengan target pasar, dan promosi di sosial media, dan (3) pelatihan strategi promosi melalui perancangan desain identitas visual yang diaplikasikan pada berbagai media, seperti: booth / gerobak, kemasan produk, desain label produk, seragam dan media promosi online. Metode yang digunakan adalah pelatihan dan pendampingan dengan pendekatan partisipatif kolaboratif. Luaran jangka panjang yang diharapkan dari pengabdian ini adalah perluasan jaringan pemasaran, peningkatakan pendapatan dan kesejahteraan PKL melalui inovasi pemasaran dan promosi.
Perancangan Desain Kemasan Produk Manisan Buah Umkm Sola Gracia untuk Membangun Citra Merek
Authors: Yuliana Stevanie , Sukmaraga Ayyub Anshari
Published: January 2023

Saat ini kemasan telah menjadi salah satu poin utama dalam proses jual beli, sehingga dengan kemasan yang menarik dan mudah ditemukan oleh masyarakat diharapkan penjualan akan semakin meningkat. Sola Gracia merupakan Usaha Kecil Menengah yang tengah berjuang untuk meningkatkan penjualan melalui penjualan dengan target konsumen usia 25 tahun hingga 40 tahun. Namun masih perlu adanya perbaikan dalam desain kemasan yang telah ada. Perancangan akan fokus pada pengenalan produk dengan kemasan yang menarik sehingga konsumen akan tertarik untuk membeli produk tersebut. Di samping itu perancangan juga mencakup pemasaran melalui media sosial sehingga konsumen akan mendapatkan produk dengan mudah. Metode yang digunakan merupakan metode research and development dan penyebaran angket. Hasil dari metode tersebut akan membantu untuk merancang kemasan yang sesuai dengan keinginan konsumen. Selanjutnya untuk menguji perancangan kemasan dibuat kemasan uji coba. Diketahui bahwa konsumen lebih menyukai kemasan yang menggugah selera dan berwarna. Hasil dari kemasan yang telah diperbaiki akan divalidasi menggunakan kuesioner online. Tahap ini digunakan untuk menunjukkan seberapa besar kemasan diterima.
Perancangan Buku Cerita Legenda Tiongkok Air Mata Putri Meng Jiang
Authors: Kristanto Jason , Sukmaraga Ayyub Anshari
Published: January 2023

Berdasarkan riset, Orang Indonesia memiliki minat yang rendah untuk membaca buku dan masih ada kurangnya representasi budaya generasi muda Tionghoa serta kurangnya pelajaran budi pekerti terhadap anak-anak, sehingga perlu adanya buku cerita legenda rakyat Tionghoa. Cerita yang digunakan adalah “Putri Meng Jiang” dari Tafsiran Zuo yang berlatarkan Dinasti Qin (221-206 SM). Metode penelitian ini menggunakan metode kualitatif dan strategi penelitian adalah Kualitatif Naratif, sehingga menghasilkan ilustrasi buku cerita yang mengenalkan budaya dan sejarah negara Tiongkok masa Dinasti Qin. Konsep perancangan bertujuan untuk memvisualisasikan cerita legenda “Putri Meng Jiang” dalam bentuk buku cerita yang disertai minigames dan video infografik, agar anak-anak tidak dilibatkan dalam membaca saja, tapi juga menambah pengetahuan. Perancangan ini disertai media pendukung seperti video teaser, Instagram Feeds, video infografik, poster, flyer, stiker emoji, filter Instagram dan merchandise seperti mug serta pembatas buku.
Perancangan Buku Ilustrasi Kisah Pasien Ruqyah Syar’iyyah untuk Usia 23-27 Tahun
Authors: Mustikaningrum Diaz Tri , Yani Aditya Rahman , Masnuna Masnuna
Published: January 2023

Fenomena perdukunan masih berjalan di era modern ini karena sebagian masyarakat masih mempercayainya. Meminta bantuan dari dukun yang berkaitan dengan hal-hal ghaib termasuk perbuatan syirik atau menyekutukan Allah. Jika perbuatan syirik tersebut dilakukan hukumnya dosa besar dalam Al-Quran. Salah satu upaya untuk menghindari yang berhubungan dengan dunia ghaib yaitu dengan cara metode Ruqyah Syari’yyah. Metode ini sudah ada sejak jaman nabi. Bahkan Rasulullah SAW pun juga pernah melakukan ruqyah.

Untuk mengatasi permasalahan ini, maka dirancanglah sebuah buku ilustrasi yang bertujuan untuk berbagi pengalaman orang-orang yang pernah melakukan ruqyah yang dapat dijadikan pelajaran untuk target audiens karena usia target audiens sudah memasuki kehidupan yang kompleks seperti pengalaman orang-orang ruqyah yaitu dalam bidang pekerjaan, rumah tangga dan sebagainya. Buku ini disertai ilustrasi yang mewakili tiap cerita supaya terlihat menarik dan tidak mudah bosan.
Perancangan Desain Mural Sebagai Media Utama Kampanye Sosial “Jogja Melawan Vandalisme”
Authors: Dewi Nuria Indah Kurnia
Published: January 2023

Perilaku Vandalisme telah mengancam identitas dan representasi Kota Yogyakrta sebagai kota budaya. Vandalisme merupakan cikal bakal masalah kejahatan yang lebih serius. Untuk mengatasi masalah tersebut diperlukan sinergisitas dari pemerintah, dan masyarakat Yogyakarta. Salah satu alternatif pemecahan masalah yang dapat ditawarkan oleh Desain Komunikasi Visual adalah dengan merancang sebuah kampanye sosial. Kampanye sosial yang dilakukan harus memenuhi tiga kriteria yaitu berpotensi berkembang menjadi gerakan yang masif, memiliki ciri khas Jogja, familiar dan dapat dilakukan oleh berbagai lapisan masyarakat terutama anak muda Yogyakarta.  Berdasarkan uraian tesebut maka,  kampanye sosial “Jogja Melawan Vandalisme” dapat menjadi alternatif media perlawanan vandalisme bagi masyarakat Yogyakarta.

Target sasaran primer dalam kampanye ini adalah remaja sekolah menengah yang menjadi pelaku aktif vandalisme atau memiliki kecenderungan menjadi pelaku. Target sasaran sekunder adalah seluruh masyarakat Yogyakarta. Kampanye ini akan dirancang dengan metode desain modern yang dituangkan dalam triadik DKV, meliputi empat tahapan yaitu identifikasi, analisis, sintesis, dan evaluasi. Teori utama yang digunakan adalah teori kriminologi broken window, teori psikologi vandalisme, dan teori tentang street art. Landasan yuridis yang melegalisasi perancangan ini adalah Peraturan Daerah No. 18 tahun 2002, tentang Pengelolaan Kebersihan, walikota Yogyakarta menginstruksikan Dinas Ketertiban untuk melakukan penanganan aksi vandalisme, dalam Pasal 16 huruf  c. Teori pendukung yang digunakan adalah teori komunikasi masaa, teori periklanan dan kampanye sosial, teori periklanan SUPER”A”, teori perilaku konsumen AISAS, serta teori dasar Desain Komunikasi Visual.

Tema kampanye yang diusung adalah “Jogja Melavan”, difokuskan untuk menyampaikan empat pesan yaitu larangan vandalisme, sosialisasi sanksi hukum, ajakan bersih-bersih, serta himbauan untuk mengisi masa remaja dengan hal yang bermanfaat. Keempat pesan akan disampaikan melalui bauran media konvensional dan non konvensional yang terdiri dari media utama dan media pendukung. Gaya desain terbuka pada berbagai gaya dan mengedepankan gaya desain yang cerah, rapi, clean, khas anak muda, dengan meminjam ikon prajurit keraton Yogyakarta yang biasa disebut Bregada.
Perancangan Video Promosi Tempat Pariwisata Air Terjun Coban Sewu di Kabupaten Malang
Authors: Sutawijaya Yonathan
Published: January 2023

Kabupaten Malang merupakan daerah yang memiliki potensi pariwisata yang indah. Salah satunya adalah air terjun Coban Sewu yang terletak di Kecamatan Ampelgading, Kabupaten Malang. Coban Sewu merupakan air terjun terindah di pulau jawa dan Indonesia. Namun berdasarkan dengan observasi awal, didapat hasil bahwa belum adanya upaya pemerintah setempat untuk mengenalkan lebih luas mengenai wisata yang dimilikinya, sehingga perlu adanya sebuah video promosi untuk mengenalkan potensi wisata air terjun Coban Sewu. Metode penelitian ini menggunakan metode kualitatif dan strategi penelitian adalah Kualitatif Deskriptif, sehingga menghasilkan video promosi yang mampu mengenalkan potensi wisata air terjun Coban Sewu yang terdapat di Kabupaten Malang kepada calon wisatawan baik domestik ataupun mancanegara
Perancangan Buku Ilustrasi Sebagai Sarana Pengenalan Jajanan Tradisional Jawa
Authors: Tjukipto Lisa Novena
Published: January 2023

Seiring berjalannya waktu, keberadaan makanan tradisional Indonesia pun menjadi semakin jarang akibat masuknya budaya penganan dari luar negeri sehingga diperlukan upaya untuk mengingatkan para generasi muda bahwa masakan tradisional itu penting. Perancangan ini bertujuan untuk menghasilkan buku ilustrasi yang mampu memperkenalkan jajanan tradisional Jawa dan menarik minat pembaca berusia 17-35 tahun. Metode yang digunakan adalah metode kualitatif, melalui studi pustaka dan pengumpulan data sekunder secara online. Konsep yang digunakan yaitu ilustrasi digital dengan style naturalis diikuti dengan ilustrasi doodle. Selain itu, buku ini dilengkapi dengan resep pembuatan agar pembaca dapat membuat sendiri jajanan dalam buku ini. Dari perancangan ini dihasilkan media utama berupa buku ilustrasi 60 halaman dengan ilustrasi 13 jenis jajanan tradisional Jawa beserta deskripsi dan resepnya, media pendukung pameran berupa x-banner dan 3 buah poster ilustrasi, serta merchandise berupa totebag, celemek, dan tatakan piring.
The Utilization of Oocyte Cryopreservation Among Indonesia Women
Authors: Sirait Batara , Handayani Nining , Sundari Ayu Mulia , Wulandari Tri Aprilliana , Sini Ivan , Polim Arie Adrianus , Rizal Muhammad , Boediono Arief
Published: January 2023

Our study aims to assess the utilization of oocyte cryopreservation (OC) in Indonesian women. Data from 122 women who had undergone OC was retrospectively analyzed from medical records. The baseline profile, clinical characteristics, and main outcomes comprising intentions for oocyte vitrification and outcomes following oocyte warming were examined. Out of 122 women who underwent OC, 49 patients returned and use their cryopreserved oocytes with a median duration of storage was two months. Arranged from the greatest to the least, participants had undergone the cycle of OC due to sperm factor [51 (41.80%)], increased embryo availability [6 (12.1%)], postponement of marriage [6 (12.1%)], social reasons [10 (8.19%)], and other reasons [8 (6.55%)]. Meanwhile, treatment due to advanced maternal age [6 (4.91%)], poor ovarian reserve [6 (4.91%)], cancer [5 (4.09%)], PCOS [2 (1.63%)], and endometriosis [2 (1.63%)] was reported among remaining subjects. Clinical pregnancy was reported in 12 (40.0%) patients constituting of each 6 (50.0%) subjects of day-3 and day-5 embryo transfer, respectively. Our study demonstrated that sperm factor, increased embryo availability, and postponement of marriage is the main reason for women undergoing OC in Indonesia.