bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental Study and Theoretical Analysis on the Compression–Shear Multiaxial Mechanical Properties of Recycled Concrete
Authors: Zhang Yongping , Peng Shuai , Du Xiaoqing , Yu Zhenpeng , Wu Jie , Xie Xinghua , Hu Yanli
Published: July 2022

Recycled concrete, which is formed by replacing coarse aggregates in ordinary concrete with recycled aggregates (RA), is of great significance for the secondary utilization of waste building resources. In civil engineering, concrete structures are sometimes subjected to a compression–shear multiaxial stress state. Therefore, research on the compression–shear multiaxial mechanical properties of recycled concrete plays an important role in engineering practice. To explore the effect of RA replacement rate on the compression–shear properties of recycled concrete, an experimental study was carried out using a compression–shear testing machine and considering five RA replacement rates and five axial compression ratios. Consequently, the failure modes and mechanical property parameters under different working conditions were obtained and were used to analyze the effects of RA replacement rate and axial compression ratio on the shear stress of recycled concrete. Eventually, the following conclusions were reached: With the growth of axial compression ratio, the shear cracks exhibit a developing trend along the oblique direction, and the friction traces on the shear surface are gradually deepened. As the replacement rate increases, the number of shear cracks is gradually increased, accompanied by increasing broken fragments falling off from the shear interface. Since the action of the axial compression ratio can effectively improve the mechanical bite force and friction on the shear interface of recycled concrete, as the axial compression ratio increases, the shear stress is gradually increased. On the other hand, due to the initial damage of RA and its weak adhesion with cement mortar, the shear stress is gradually reduced with the increase of RA replacement rate. Meanwhile, the increase in shear stress shows a gradually decreasing trend with the growth of axial compression ratio. Specifically, for the RA replacement rates of 0% and 100%, the shear stress increased by 4.06 times and 3.21 times, respectively, under the influence of the axial compression ratio. Under different axial compression ratios, the shear stress was reduced by 43~46%, due to the increase of RA replacement rate. In addition, based on the octahedral stress space and the principal stress space, a compression–shear multiaxial failure criterion and shear stress calculation model for recycled concrete were proposed, by considering the effect of the RA replacement rate. The outcomes of this research are of great significance for engineering applications and the development of recycled concrete.
Microstructure and Mechanical Properties of AZ91 Rein-Forced with High Volume Fraction of Oriented Short Carbon Fibers
Authors: Ataya Sabbah , El-Sayed Seleman Mohamed M. , Latief Fahamsyah H. , Ahmed Mohamed M. Z. , Hajlaoui Khalil , Elshaghoul Yousef G. Y. , Habba Mohamed I. A.
Published: July 2022

In this study, AZ91/23 vol.% short carbon fiber composite was produced by a squeeze casting technique using a cylindrical pre-form of treated carbon fibers, in which the fibers are randomly oriented in the horizontal plane. Cylindrical specimens (height = 9 mm and diameter = 6 mm) were machined from the as-cast AZ91 matrix and its composite. The full behavior of the produced composite was studied through the test specimens machined in two directions, namely parallel to the reinforced plane (in the radial direction of the cast cylinder) and normal to the reinforced plane (in the axial direction of the cast composite). The microstructures of the produced composite specimens were investigated using SEM equipped with EDS analysis. Density, hardness, compressive, and wear behavior were also investigated. For comparison, the AZ91 matrix was evaluated as a reference. The microstructure of the produced AZ91 matrix alloy and its composite revealed dense materials without casting defects. Both composite specimens show improvement in hardness, compressive strength, and wear properties over the AZ91 matrix. The compressive and wear properties are more fiber orientation-dependent than the hardness results. The parallel composite specimen depicts the highest compressive properties in terms of yield compressive strength (311 MPa) and ultimate compressive strength (419 MPa), compared to that shown by the AZ91 matrix and the normal composite specimen. This improvement in compressive strength was at the expense of ductility. The parallel composite specimen shows the lowest ductility (R = 3.8%), compared to that given by the normal composite specimen (R = 7.1) and the AZ91 matrix alloy (R = 13.6). The wear testing results showed that at the highest wear load of 5 N, the material weight loss of the parallel composite specimen decreases by 44% and 64% compared to the AZ91 matrix and the normal composite specimen, respectively.
The Use of Acellular Fish Skin Grafts in Burn Wound Management—A Systematic Review
Authors: Luze Hanna , Nischwitz Sebastian Philipp , Smolle Christian , Zrim Robert , Kamolz Lars-Peter
Published: July 2022

Background and Objectives: Burn wound healing and management continues to be a major challenge for patients and health care providers resulting in a considerable socio-economic burden. Recent advances in the development of applicable xenografts as an alternative to split-thickness skin grafts have allowed for the development of acellular fish skin. Acellular fish skin acts as a skin substitute, reducing inflammatory responses and advancing proinflammatory cytokines that promote wound healing. Due to these beneficial wound healing properties, acellular fish skin might represent an effective treatment approach in burn wound management. Materials and Methods: A systematic review of the literature, up to March 2022, was conducted using the electronic databases PubMed and Web of Science. Titles and abstracts were screened for the following key terms (variably combined): “fish skin”, “fish skin grafts”, “acellular fish skin”, “Omega3 Wound matrix”, “xenograft”, “burn injury”, “burns”. Results: In total, 14 trials investigating the effects of acellular fish skin in burn wounds or split-thickness donor sites were determined eligible and included in the present review. Existing evidence on the use of acellular fish skin indicates an acceleration of wound healing, reduction in pain and necessary dressing changes as well as treatment-related costs and improved aesthetic and functional outcomes compared to conventional treatment options. Conclusions: Acellular fish skin xenografts may represent an effective, low-cost alternative in treatment of superficial- and partial-thickness burns. However, results mainly originate from preclinical and small cohort studies. Future larger cohort studies are warranted to elucidate the full potential of this promising approach.
Prevalence of Brain Incidental Lesions Detected by 68Ga-DOTA Peptides PET/CT
Authors: Albano Domenico , Treglia Giorgio , Dondi Francesco , Bertagna Francesco
Published: July 2022

Background and Objectives: 68Ga-DOTA peptides positron emission tomography/computed tomography (PET/CT) is usually applied for the study of neuroendocrine tumours, but other tumours such as meningioma may also have an increased radiopharmaceutical uptake. The aim of this retrospective study was to establish the prevalence and the meaning of brain incidental uptake among patients who performed 68Ga-DOTA peptides PET/CT for other reasons. Materials and Methods: Overall, 510 68Ga-DOTA peptides PET/CT scans performed between January 2018 and February 2022 from 430 patients were reviewed for the analysis of incidental brain radiopharmaceutical uptake. All brain incidentalomas were compared with brain magnetic resonance imaging (MRI) and/or contrast-enhanced CT performed within an average time interval of ±60 days from PET/CT scan. Results: A total of 48 patients (14%) presented incidental focal intracranial radiotracer uptake. Thirty-eight (11%) of them had a suspected meningioma confirmed by MRI or contrast-enhanced CT imaging features. The remaining 10 had a final diagnosis different from meningioma (5 as brain metastases and 2 as venous anomalies) or were lost during the follow-up without performing MRI (n = 3). The average maximal standardized uptake value (SUVmax) of the suspected meningioma was 16.5 (range 5–33), and the average lesion to brain SUVmax ratio was 351 (range 80–550). Conclusions: Brain incidental uptake from the 68Ga-DOTA peptides PET/CT is not so rare, and meningioma is the most frequent cause.
PMCHWT Solver Accelerated by Adaptive Cross Approximation for Efficient Computation of Scattering from Metal Nanoparticles
Authors: Liu Zhiwei , Xi Longfeng , Bao Yang , Cheng Ziyue
Published: July 2022

An accelerated algorithm that can efficiently calculate the light scattering of a single metal nanoparticle was proposed. According to the equivalent principle, the method of moment (MoM) transforms the Poggio–Miller–Chang–Harrington–Wu–Tsai (PMCHWT) integral equations into linear algebraic equations, which are solved by the flexible generalized minimal residual solver (FGMRES). Each element of near field MoM impedance matrix was described by Rao–Wilton–Glisson (RWG) basis functions and calculated by double surface integrals. Due to the low-rank property, the adaptive cross approximation (ACA) algorithm based on the octree data structure was applied to compress the MoM impedance matrix of far field action leading to the significant reduction of solution time and memory. Numerical results demonstrated that the proposed method is both accurate and efficient. Compared with the traditional MoM, the ACA algorithm can significantly reduce the impedance matrix filling time and accelerate the scattering field’s computation from actual metal nanoparticles using PMCHWT integral equations.
Mechanical Characterization and Modelling of Subcellular Components of Oocytes
Authors: Du Yue , Chen Yizhe , Zhang Shuai , Cheng Dai , Liu Yaowei , Zhao Qili , Sun Mingzhu , Cui Maosheng , Zhao Xin
Published: July 2022

The early steps of embryogenesis are controlled exclusively by the quality of oocyte that linked closely to its mechanical properties. The mechanical properties of an oocyte were commonly characterized by assuming it was homogeneous such that the result deviated significantly from the true fact that it was composed of subcellular components. In this work, we accessed and characterized the subcellular components of the oocytes and developed a layered high-fidelity finite element model for describing the viscoelastic responses of an oocyte under loading. The zona pellucida (ZP) and cytoplasm were isolated from an oocyte using an in-house robotic micromanipulation platform and placed on AFM to separately characterizing their mechanical profiling by analyzing the creep behavior with the force clamping technique. The spring and damping parameters of a Kelvin–Voigt model were derived by fitting the creeping curve to the model, which were used to define the shear relaxation modulus and relaxation time of ZP or cytoplasm in the ZP and cytoplasm model. In the micropipette aspiration experiment, the model was accurate sufficiently to deliver the time-varying aspiration depth of the oocytes under the step negative pressure of a micropipette. In the micropipette microinjection experiment, the model accurately described the intracellular strain introduced by the penetration. The developed oocyte FEM model has implications for further investigating the viscoelastic responses of the oocytes under different loading settings.
Thermally Induced Knudsen Forces for Contactless Manipulation of a Micro-Object
Authors: Otic Clint John Cortes , Yonemura Shigeru
Published: July 2022

In this paper, we propose that thermally induced Knudsen forces in a rarefied gas can be exploited to achieve a tweezer-like mechanism that can be used to trap and grasp a micro-object without physical contact. Using the direct simulation Monte Carlo (DSMC) method, we showed that the proposed mechanism is achieved when a heated thin plate, mounted perpendicularly on a flat substrate, is placed close to a colder object; in this case, a beam. This mechanism is mainly due to the pressure differences induced by the thermal edge flows at the corners of the beam and the thermal edge flow at the tip of the thin plate. Specifically, the pressure on the top surface of the beam is smaller than that on its bottom surface when the thin plate is above the beam, while the pressure on the right side of the beam is smaller than that on its left side when the thin plate is located near the right side of the beam. These differences in pressure generate a force, which attracts the beam to the plate horizontally and vertically. Furthermore, this phenomenon is enhanced when the height of the beam is shorter, such that the horizontal and vertical net forces, which attract the beam to the plate, become stronger. The mechanism proposed here was also found to depend significantly on the height of the beam, the temperature difference between the thin plate and the beam, and the Knudsen number.
A Continuous Microfluidic Concentrator for High-Sensitivity Detection of Bacteria in Water Sources
Authors: Choo Seunghee , Lim Hyunjung , Kim Tae , Park Jion , Park Kyu , Park Chaewon , Lim Chae , Nam Jeonghun
Published: July 2022

Water contamination is a critical issue that threatens global public health. To enable the rapid and precise monitoring of pathogen contamination in drinking water, a concentration technique for bacterial cells is required to address the limitations of current detection methods, including the culture method and polymerase chain reaction. Here we present a viscoelastic microfluidic device for the continuous concentration of bacterial cells. To validate the device performance for cell concentration, the flow characteristics of 2-μm particles were estimated in viscoelastic fluids at different concentrations and flow rates. Based on the particle flow distributions, the flow rate factor, which is defined as the ratio of the inlet flow rate to the outlet flow rate at the center outlet, was optimized to achieve highly concentrated bacterial cells by removal of the additional suspending medium. The flow characteristics of 0.5-, 0.7-, and 1.0-μm-diameter particles were evaluated to consider the effect of a wide spectrum of bacterial size distribution. Finally, the concentration factor of bacterial cells, Staphylococcus aureus, suspended in a 2000-ppm polyethylene oxide solution was found to be 20.6-fold at a flow rate of 20 μL/min and a flow rate factor of 40.
Comparison of the Effectiveness of Drag Reduction Devices on a Simplified Truck Model through Numerical Simulation
Authors: Charles Terrance , Yang Zhiyin
Published: July 2022

The aerodynamic efficiency of trucks is very low because of their non-streamlined box shape, which is subject to practical constraints, leaving little room for improvement in terms of aerodynamic efficiency. Hence, other means of improving the aerodynamic efficiency of trucks are needed, and one practical yet relatively simple method to reduce aerodynamic drag is deploying drag reduction devices on trucks. This paper describes a numerical study of flow over a simplified truck with drag reduction devices. The numerical approach employed was Reynolds-averaged Navier–Stokes (RANS). Four test cases with different drag reduction devices deployed around the tractor–trailer gap region were studied. The effectiveness of those drag reduction devices was assessed, and it was demonstrated that in all four cases, the aerodynamic drag was reduced compared with the baseline case without any drag reduction devices. The most effective device was case 4 (about 24% reduction), with a roof deflector, side extenders, and five cross-flow vortex trap devices (CVTDs). Flow field analysis was performed to shed light on drag reduction mechanisms, which confirmed our previous findings that the main reason for the drag reduction was the reduced pressure on the front face of the trailer, while the reduction in the turbulence level in the tractor–trailer gap region contributed much less to the overall drag reduction.
Sociocultural Influences Contribute to Overeating and Unhealthy Eating: Creating and Maintaining an Obesogenic Social Environment in Indigenous Communities in Urban Fiji
Authors: Buksh Shazna M. , de Wit John B. F. , Hay Phillipa
Published: July 2022

Pacific Island countries (PICs), such as Fiji, lead the world statistics in obesity and deaths caused by non-communicable diseases. The impacts of obesity overburden the healthcare system and social services and have major impacts on the Fijian economy. This study is the first of its kind to undertake an in-depth exploration of the determinants of the obesity epidemic in PICs by exploring the sociocultural influences and situations that impact nutrient transitions, overconsumption, and unhealthy eating in an urban indigenous community. In-depth qualitative interviews were conducted with 15 indigenous Fijian women from the largest urban center in Fiji who self-identified as gatekeepers of family meal planning, preparing, and shopping for groceries, fruits, and vegetables. The women identified several cultural norms and expectations of both the individuals providing the food and the individuals consuming the food that create and maintain an obesogenic social environment. Moreover, participants also shared a misplaced value on meat, energy-dense foods, junk food, and fast foods that further contribute to unhealthy eating and overeating within this urban indigenous community. These novel findings highlight the importance of considering sociocultural influences on unhealthy eating and overeating and may be used to assist decision-makers in developing contextualized obesity prevention strategies and health messaging to target obesity in this community.
College Campus Food Pantry Program Evaluation: What Barriers Do Students Face to Access On-Campus Food Pantries?
Authors: Brito-Silva Francilia de K. , Wang Wanyi , Moore Carolyn E. , Warren Cynthia , Miketinas Derek C. , Tucker Wesley J. , Davis Kathleen E.
Published: July 2022

The purpose of this study was to explore barriers Texas Woman’s University (TWU) students face in accessing on-campus food pantries. This cross-sectional, survey-based study was conducted in Fall 2021. Students’ use of the food pantries and barriers to utilization, including qualitative questions, were evaluated using descriptive statistics and thematic analyses. Students (n = 529) completed the survey. Despite a high prevalence of food insecurity (49.2%), most students reported never using the pantries (89.8%). Almost half of the students were unaware that these pantries existed on campus (47.8%). More than one in four students believed there were barriers to accessing the pantries, with time tissues, lack of transportation, limited food pantry hours of operation, and social stigma most commonly cited as major barriers to access. Food insecurity remains an urgent problem at TWU since the prevalence has remained high since 2019 despite the institutions’ efforts to reduce it. One of those resources has not been utilized as expected, which might impede improvements in food security among students. TWU on-campus food pantries can use these findings to address major barriers by offering after-hours access through the libraries or campus police, partnering with public transportation, and normalizing accessing food assistance.
B Vitamins and Incidence of Advanced Age-Related Macular Degeneration: The Alienor Study
Authors: Merle Bénédicte M. J. , Barthes Stéphanie , Féart Catherine , Cougnard-Grégoire Audrey , Korobelnik Jean-François , Rougier Marie-Bénédicte , Delyfer Marie-Noëlle , Delcourt Cécile
Published: July 2022

B vitamins may protect against age-related macular degeneration (AMD). We evaluated the associations of dietary intake and serum vitamins with the incidence of advanced AMD in the Alienor study. The Alienor study is a prospective population-based cohort of 963 residents of Bordeaux, France, who were 73 years or older at baseline (2006–2008). Examinations were performed every two years over an eight-year period. The incidence of AMD is based on retinal fundus photographs and spectral-domain optical coherence tomography examinations. Among the 861 included participants, 93 developed incident AMD during a median follow-up time of 9.8 years. Participants with normal serum folate (≥10 nmol/L) significantly had a 51% reduced risk for AMD in the fully adjusted Cox model (HR, 0.49 [95% CI, 0.25–0.95], p = 0.036). Participants with a higher dietary intake of B5 and B6 vitamins had a lower risk for developing AMD of up to 28% (HR, 0.72 for 1-SD increase [0.53–0.99], p = 0.049; HR, 0.90 [0.81–0.99], p = 0.049, respectively). This cohort study of older adults suggests a strong association between a normal serum folate status, a high dietary intake of B5 and B6 and a lower risk for developing advanced AMD. Adopting a healthy diet rich in B vitamins may help to reduce vision loss due to AMD.
Meeting 24-Hour Movement and Dietary Guidelines: Prevalence, Correlates and Association with Weight Status among Children and Adolescents: A National Cross-Sectional Study in China
Authors: Yang Yide , Yuan Shuqian , Liu Qiao , Li Feifei , Dong Yanhui , Dong Bin , Zou Zhiyong , Ma Jun , Baker Julien S. , Li Xianxiong , Liang Wei
Published: July 2022

China is confronted with a “double burden” of underweight and overweight/obesity in children and adolescents. This study aimed to investigate the prevalence and correlates of meeting 24 h movement and dietary guidelines among Chinese children and adolescents. Further, the study aimed to examine the association of meeting 24 h movement and dietary guidelines with weight status in Chinese children and adolescents. A total of 34,887 Chinese children and adolescents were involved. Only 2.1% of participants met the 24 h movement guidelines. Compared to those who met all three 24 h movement guidelines, those who only met the sleep duration guideline was significantly associated with a higher risk of underweight (p < 0.05), and those who only met the moderate-to-vigorous physical activity, or screen time guidelines were significantly associated with a higher risk of overweight/obesity (p < 0.05). Compared with those meeting the dietary guidelines, those who did not meet the soft drink intake guideline had a significantly lower risk of underweight (p < 0.05), those who did not meet the fruit intake guideline had a significantly lower risk of overweight/obesity (p < 0.05), and those who did not meet the milk intake guideline showed a significantly higher risk of overweight/obesity (p < 0.001). These findings indicate a significant association between meeting the 24 h movement and dietary guidelines and weight status among Chinese children and adolescents.
Leucine Supplementation in Cancer Cachexia: Mechanisms and a Review of the Pre-Clinical Literature
Authors: Beaudry Anna G. , Law Michelle L.
Published: July 2022

Cancer cachexia (CC) is a complex syndrome of bodily wasting and progressive functional decline. Unlike starvation, cachexia cannot be reversed by increased energy intake alone. Nonetheless, targeted nutritional support is a necessary component in multimodal syndrome management. Due to the highly catabolic nature of cancer cachexia, amino acid supplementation has been proposed. Interestingly, leucine has been found to increase protein synthesis and decrease protein degradation via mTORC1 pathway activation. Multiple pre-clinical studies have explored the impact of leucine supplementation in cachectic tumor-bearing hosts. Here, we provide an overview of leucine’s proposed modes of action to preserve lean mass in cachexia and review the current pre-clinical literature related to leucine supplementation during CC. Current research indicates that a leucine-rich diet may attenuate CC symptomology; however, these works are difficult to compare due to methodological differences. There is need for further pre-clinical work exploring leucine’s potential ability to modulate protein turnover and immune response during CC, as well as the impact of additive leucine on tumor growth.
Inosine Pretreatment Attenuates LPS-Induced Lung Injury through Regulating the TLR4/MyD88/NF-κB Signaling Pathway In Vivo
Authors: Mao Bingyong , Guo Weiling , Tang Xin , Zhang Qiuxiang , Yang Bo , Zhao Jianxin , Cui Shumao , Zhang Hao
Published: July 2022

Inosine is a type of purine nucleoside, which is considered to a physiological energy source, and exerts a widely range of anti-inflammatory efficacy. The TLR4/MyD88/NF-κB signaling pathway is essential for preventing host oxidative stresses and inflammation, and represents a promising target for host-directed strategies to improve some forms of disease-related inflammation. In the present study, the results showed that inosine pre-intervention significantly suppressed the pulmonary elevation of pro-inflammatory cytokines (including tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β)), malondialdehyde (MDA), nitric oxide (NO), and reactive oxygen species (ROS) levels, and restored the pulmonary catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and myeloperoxidase (MPO) activities (p < 0.05) in lipopolysaccharide (LPS)-treated mice. Simultaneously, inosine pre-intervention shifted the composition of the intestinal microbiota by decreasing the ratio of Firmicutes/Bacteroidetes, elevating the relative abundance of Tenericutes and Deferribacteres. Moreover, inosine pretreatment affected the TLR4/MyD88/NF-κB signaling pathway in the pulmonary inflammatory response, and then regulated the expression of pulmonary iNOS, COX2, Nrf2, HO-1, TNF-α, IL-1β, and IL-6 levels. These findings suggest that oral administration of inosine pretreatment attenuates LPS-induced pulmonary inflammatory response by regulating the TLR4/MyD88/NF-κB signaling pathway, and ameliorates intestinal microbiota disorder.
Correlation between Serum 25-Hydroxyvitamin D Level and Depression among Korean Women with Secondary Amenorrhea: A Cross-Sectional Observational Study
Authors: Kim Gyung-Mee , Jeon Gyun-Ho
Published: July 2022

Vitamin D deficiency is considered a major public health problem worldwide and has been reported as having an association with depression. However, studies on the association between vitamin D deficiency and depressive symptoms in secondary amenorrhea (SA) patients are still scarce. This study examined the relationship between serum 25-hydroxyvitamin D (25(OH)D) levels and depressive symptoms among Korean women with SA. In this cross-sectional observational study, 78 patients with SA were initially recruited. Clinical and biochemical parameters, including serum 25(OH)D level, were measured. Data from 63 SA patients who met the study inclusion criteria and completed psychiatric assessments were finally analyzed. We analyzed their association with depression using a hierarchical regression model. The average serum 25(OH)D level was 34.40 ± 24.02 ng/mL, and 41.3% of the women with SA were vitamin D-deficient (<20 ng/mL). The total score of the Korean version of the Hamilton Depression Rating Scale (K-HDRS) was negatively related to serum 25(OH)D levels, free testosterone, and serum anti-Müllerian hormone (AMH) after adjusting for age and BMI (r = −0.450, p < 0.001; r = −0.258, p = 0.045; and r = −0.339, p = 0.006, respectively). Serum 25(OH)D levels and AMH levels were the most powerful predictors of depressive severity when using the K-HDRS in SA patients (β = −0.39, p < 0.005; β = −0.42, p < 0.005, respectively). This study showed that low serum 25(OH)D levels were associated with the severity of depressive symptoms in SA patients. This observation suggests that the evaluation of vitamin D deficiency for the risk of depression may be necessary in patients with SA.
The Potential Roles of Dietary Anthocyanins in Inhibiting Vascular Endothelial Cell Senescence and Preventing Cardiovascular Diseases
Authors: Dong Yonghui , Wu Xue , Han Lin , Bian Ji , He Caian , El-Omar Emad , Gong Lan , Wang Min
Published: July 2022

Cardiovascular disease (CVD) is a group of diseases affecting the heart and blood vessels and is the leading cause of morbidity and mortality worldwide. Increasingly more evidence has shown that the senescence of vascular endothelial cells is the key to endothelial dysfunction and cardiovascular diseases. Anthocyanin is a type of water-soluble polyphenol pigment and secondary metabolite of plant-based food widely existing in fruits and vegetables. The gut microbiome is involved in the metabolism of anthocyanins and mediates the biological activities of anthocyanins and their metabolites, while anthocyanins also regulate the growth of specific bacteria in the microbiota and promote the proliferation of healthy anaerobic flora. Accumulating studies have shown that anthocyanins have antioxidant, anti-inflammatory, and anti-aging effects. Many animal and in vitro experiments have also proven that anthocyanins have protective effects on cardiovascular-disease-related dysfunction. However, the molecular mechanism of anthocyanin in eliminating aging endothelial cells and preventing cardiovascular diseases is very complex and is not fully understood. In this systematic review, we summarize the metabolism and activities of anthocyanins, as well as their effects on scavenging senescent cells and cardioprotection.
Short-Term Administration of Lemon Balm Extract Ameliorates Myocardial Ischemia/Reperfusion Injury: Focus on Oxidative Stress
Authors: Draginic Nevena , Milosavljevic Isidora , Andjic Marijana , Jeremic Jovana , Nikolic Marina , Sretenovic Jasmina , Kocovic Aleksandar , Srejovic Ivan , Zivkovic Vladimir , Bolevich Sergey , Bolevich Stefani , Curcic Svetlana , Jakovljevic Vladimir
Published: July 2022

We aimed to investigate the cardioprotective effects of ethanolic Melissa officinalis L. extract (ME) in the rat model of myocardial ischemia/reperfusion (I/R) injury. Thirty-two Wistar rats were randomly divided into a CTRL non-treated control group with myocardial I/R injury and three experimental groups of rats treated with 50, 100, or 200 mg/kg of ME for 7 days per os. Afterward, hearts were isolated, and cardiodynamic function was assessed via the Langendorff model of global 20 min ischemia and 30 min reperfusion. Oxidative stress parameters were determined spectrophotometrically from the samples of coronary venous effluent (O2−, H2O2, TBARS, and NO2−,) and heart tissue homogenate (TBARS, NO2−, SOD, and CAT). H/E and Picrosirius red staining were used to examine cardiac architecture and cardiac collagen content. ME improved cardiodynamic parameters and achieved to preserve cardiac architecture after I/R injury and to decrease fibrosis, especially in the ME200 group compared to CTRL. ME200 and ME100 markedly decreased prooxidants TBARS, O2−, and H2O2 while increasing NO2−. Hereby, we confirmed the ME`s ability to save the heart from I/R induced damage, even after short-term preconditioning in terms of preserving cardiodynamic alterations, cardiac architecture, fibrosis, and suppressing oxidative stress, especially in dose of 200 mg/kg.
Vascular Repair by Grafting Based on Magnetic Nanoparticles
Authors: Liu Xin , Wang Nan , Liu Xiyu , Deng Rongrong , Kang Ran , Xie Lin
Published: July 2022

Magnetic nanoparticles (MNPs) have attracted much attention in the past few decades because of their unique magnetic responsiveness. Especially in the diagnosis and treatment of diseases, they are mostly involved in non-invasive ways and have achieved good results. The magnetic responsiveness of MNPs is strictly controlled by the size, crystallinity, uniformity, and surface properties of the synthesized particles. In this review, we summarized the classification of MNPs and their application in vascular repair. MNPs mainly use their unique magnetic properties to participate in vascular repair, including magnetic stimulation, magnetic drive, magnetic resonance imaging, magnetic hyperthermia, magnetic assembly scaffolds, and magnetic targeted drug delivery, which can significantly affect scaffold performance, cell behavior, factor secretion, drug release, etc. Although there are still challenges in the large-scale clinical application of MNPs, its good non-invasive way to participate in vascular repair and the establishment of a continuous detection process is still the future development direction.
Synthesis and Characterization of High Viscosity Cationic Poly(Proline-Epichlorohydrin) Composite Polymer with Antibacterial Functionalities
Authors: Nayunigari Mithil Kumar , Suri Rominder , Andaluri Gangadhar
Published: July 2022

We report microbial resistance and catalytic activity of high viscosity cationic poly(proline-epichlorohydrin) composite (PRO-EPI) in the aqueous system. The PRO-EPI was prepared by a simple polycondensation, followed by FTIR, 1H NMR, SEM, DLS, viscosity, and DSC/TGA characterization. Several concentrations of the PRO-EPI were tested against Gram-negative (E. coli and Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) microorganisms. The antimicrobial screening revealed that PRO-EPI was a potent antimicrobial agent with the least inhibitory concentrations (MICs) of 128 µg/mL against Gram-negative microorganisms. The PRO-EPI indicated no inhibitory effect against Gram-positive microorganisms. It was determined that PRO-EPI contains polymeric-quaternary ammonium compounds that inactivate the Gram-negative microorganisms by a dual mode of action and carries domains for electrostatic interaction with the microbial membrane and an intracellular target. To study the removal of toxic industrial wastewater, congo red (CR) was tested using sodium borohydride as a reducing agent. Adsorption was achieved within 20 min at a rate constant of 0.92 ks−1. UV–vis spectra showed that the removal of CR in the reaction solution was due to the breakup of the azo (–N=N–) bonds and adsorption of aromatic fragments. PRO is biodegradable and non-toxic, and PRO-EPI was found to be both antimicrobial and also acts as a catalyst for the removal of congo red dye.
Analysis of Creep Properties and Factors Affecting Wood Plastic Composites
Authors: Feng Li , Zhao Chunyan
Published: July 2022

Wood plastic composite (WPC) materials are mainly used as building slabs and load-bearing slabs, which will cause creep deformation, structural failure, and safety problems. Therefore, this work used high-density polyethylene and poplar wood flour as the main raw materials to prepare wood–plastic boards. The bending creep tests of wood–plastic sheets were carried out using an orthogonal test method. According to the creep test results, the influences of the WPC ratio molding temperature, pelleting temperature, coupling agent screw speed, and other technological factors on the creep properties of WPC composites under different loads are analyzed, and the influences of WPC creep properties on structural reliability are also analyzed. The results indicate that the wood–plastic ratio and screw speed are significant factors when the load is at 30% bending strength within the 24h creep test. When the load is at 50% bending strength, the wood–plastic ratio and molding temperature are the significant factors. When the load is at 70% bending strength, the wood–plastic ratio is the most significant factor. When the load is at 50% bending strength within the 240 h creep test, the wood–plastic ratio and molding temperature are significant factors. When the load is at 30% bending strength, the influence of each factor on the creeping variable is provided in the following descending order: wood–plastic ratio, molding temperature, granulation temperature, coupling agent, and screw speed, but none of them are significant factors.
Multi-Objective Optimization of Curing Profile for Autoclave Processed Composites: Simultaneous Control of Curing Time and Process-Induced Defects
Authors: Tang Wenyuan , Xu Yingjie , Hui Xinyu , Zhang Wenchang
Published: July 2022

The contribution of this work is introducing a multi-objective optimization method based on finite element (FE) numerical simulation to simultaneously control the curing time and cure-induced defects of C-shaped composites during a curing cycle. Thermochemical and thermomechanical coupled analysis is performed and validated experimentally to understand the evolution details of temperature, degree of cure and curing deformation. Aiming to achieve the simultaneous control of manufacturing cost and composite quality, the curing profile is optimized by employing the critical factors including the total curing time, the maximum degree of cure difference, and the curing deformation. The optimization result shows that the designed curing profile can effectively reduce the curing time and guarantee the curing quality. The total curing time of the optimization is reduced by 19%. The verification experiment is also conducted to prove the accuracy and effectiveness of the proposed optimization method.
The Influence of Environmental Factors on the Quality of GPR Data: The Borre Monitoring Project
Authors: Schneidhofer Petra , Tonning Christer , Cannell Rebecca J. S. , Nau Erich , Hinterleitner Alois , Verhoeven Geert J. , Gustavsen Lars , Paasche Knut , Neubauer Wolfgang , Gansum Terje
Published: July 2022

The Borre Monitoring Project investigated how environmental factors, in particular, precipitation and soil moisture variation as well as different soil and sediment types, affect the quality of GPR data collected for archaeological purposes. To study these questions, regular GPR surveys were conducted over a period of 14 months across a test area covering a hall building at the Iron and Viking Age site of Borre in Norway. In order to obtain in situ measurements of environmental factors relevant for electromagnetic wave propagation including volumetric water content, bulk electrical conductivity, ground temperature, and precipitation, three monitoring stations were erected at the test site. Soil and sediment samples taken from the profiles at the respective monitoring stations were analysed to gain a basic description of their physical and chemical properties. Twelve GPR surveys were conducted roughly once a month between August 2016 and September 2017 and the results clearly indicated differences in the quality of the data collected. To better understand the underlying causes for this variation, GPR data were compared against and integrated with the in situ measurements gathered using the monitoring stations. The results of this analysis emphasised the benefit of dry conditions, which, if prevailing over a longer period of time, proved to generate GPR data of the highest quality. Seasonality could not be attested; instead, data quality was governed by small-scale weather patterns, where the time and intensity of rainfall events prior to the surveys as well as sudden changes in air temperature played a decisive role. While the results of this study are only valid for sites with similar settings such as Borre, they emphasise the importance of considering the environmental factors during all stages of a GPR survey and highlight the need for further studies investigating other settings.
Fusion of Spatially Heterogeneous GNSS and InSAR Deformation Data Using a Multiresolution Segmentation Algorithm and Its Application in the Inversion of Slip Distribution
Authors: Yan Huineng , Dai Wujiao , Liu Hongzhi , Gao Han , Neely Wesley R. , Xu Wenbin
Published: July 2022

The fusion of global navigation satellite system (GNSS) and interferometric synthetic aperture radar (InSAR) deformation data can leverage the advantages of GNSS high temporal resolution and InSAR high spatial resolution, and obtain more abundant deformation data for constraints on geophysical structural and mechanical parameters. Existing studies seldom consider the spatial heterogeneity of largescale deformation data, which easily leads to obvious spatial aggregation of errors in the results of fusion. Here, we propose a novel multiresolution segmentation fusion (MRSF) method that uses a multiresolution segmentation algorithm to automatically classify the spatial heterogeneity of InSAR deformation data with similar deformation characteristics. We applied the MRSF method to the fusion of GNSS and InSAR deformation data covering the central valley aquifer system (CVAS) in southern California to verify its precision and robustness. Results show that the MRSF method can accurately reflect spatiotemporal evolution characteristics of displacement data and reliably estimate deformation for the times and locations of missing data. We then tested this method for geophysical parameter estimation by constructing three different sets of data, including dense GNSS sites, sparse GNSS sites, and sparse GNSS sites fused with InSAR data using MRSF, to invert the slip distribution of the Cascadia subduction zone. Results show that the inverted slip of the fused InSAR and GNSS data is comparable to that of the dense GNSS sites. Therefore, the MRSF method can obtain deformation results with high precision and high spatiotemporal resolution and effectively compensate for the lack of data caused by sparse GNSS sites during the geophysical inversion process.
New Archaeological Discoveries Based on Spatial Information Technology and Cultural Analysis: Taking the Study of the Spatial Relationship between Ancient Chinese Capitals and the Natural Environment as an Example
Authors: Chen Siliang , Xu Xinyue , Sun Kaiyu , Dong Yue , Yu Mengzhe , Hu Qingwu , Gong Jiangbo
Published: July 2022

How to combine science and technology with the humanities in the research on ancient cities to reveal ancient peoples’ urban planning thoughts is worthy of in-depth study. The capitals of the Western Han dynasty as well as the Sui and Tang dynasties were some of the greatest cities in the world at the time. This paper takes them as its subjects and puts forward a method to study the spatial relationship between ancient cities and the natural environment by combining spatial information technology and cultural analysis. Firstly, satellite images, elevation maps, urban ichnographies, and literature materials were collected and sorted to deeply understand the cultural thoughts involved in ancient urban planning; based on this, key element points were marked and rechecked on the spot, and the above drawings were accurately superimposed by GIS technology to form a geographic information base that integrated multisource information. Then, Python was used to construct a “decision model of spatial relationship between urban elements and natural elements”, and rules as well as parameters were set through man–machine collaboration. The decision model was used to test the geographic information base, and the information of strong correlations between urban objects and natural objects was outputted. The drawings were exported after screening, and a visual expression was realized with Illustrator software. The research results indicated that this analysis method was feasible, effective, and easy to promote. The new archaeological discoveries included eight important line segments with a 9:6 proportional relationship (which represents the balance of Yin and Yang) and two important line segments with a 9:5 proportional relationship (which represents the supreme imperial power) in the capitals of the Western Han dynasty as well as the Sui and Tang dynasties, and 16 contraposition lines in a positive direction or oblique 45° direction (which reflects the close relationship between urban elements and natural elements). We consider that the two capitals were intentionally closely related to natural environments such as mountain peaks and valley entrances in the planning stage, and that proportions and scales with profound humanistic meaning were selected. The capital of the Sui and Tang dynasties was specially aligned with the capital of the Western Han dynasty in space. These characteristics embody ancient Chinese Confucian cultural thoughts such as the “integration of yang and yin”, “harmony between nature and humans”, the “supremacy of emperors”, and the “use of numbers and shapes to convey meaning”.
A Deep-Learning Approach to Soil Moisture Estimation with GNSS-R
Authors: Roberts Thomas Maximillian , Colwell Ian , Chew Clara , Lowe Stephen , Shah Rashmi
Published: July 2022

GNSS reflection measurements in the form of delay-Doppler maps (DDM) can be used to complement soil measurements from the SMAP Mission, which has a revisit rate too slow for some hydrological/meteorological studies. The standard approach, which only considers the peak value of the DDM, is subject to a significant amount of uncertainty due to the fact that the peak value of the DDM is not only affected by soil moisture, but also complex topography, inundation, and overlying vegetation. We hypothesize that information from the entire 2D DDM could help decrease uncertainty under various conditions. The application of deep-learning-based techniques has the potential to extract additional information from the entire DDM, while simultaneously allowing for the incorporation of additional contextual information from external datasets. This work explored the data-driven approach of convolutional neural networks (CNNs) to determine complex relationships between the reflection measurement and surface parameters, providing the groundwork for a mechanism to achieve improved global soil moisture estimates. A CNN was trained on CYGNSS DDMs and contextual ancillary datasets as inputs, with aligned SMAP soil moisture values as the targets. Data were aggregated into training sets, and a CNN was developed to process them. Predictions from the CNN were studied using an unbiased subset of samples, showing strong correlation with the SMAP target values. With this network, a soil moisture product was generated using DDMs from 2017–2019 which is generally comparable to existing global soil moisture products, and shows potential advantages in spatial resolution and coverage over regions where SMAP does not perform well. Comparisons with in-situ measurements demonstrate the correlation between the network predictions and ground truth with high temporal resolution.
Prediction of Sea Surface Temperature in the East China Sea Based on LSTM Neural Network
Authors: Jia Xiaoyan , Ji Qiyan , Han Lei , Liu Yu , Han Guoqing , Lin Xiayan
Published: July 2022

Sea surface temperature (SST) is an important physical factor in the interaction between the ocean and the atmosphere. Accurate monitoring and prediction of the temporal and spatial distribution of SST are of great significance in dealing with climate change, disaster prevention, disaster reduction, and marine ecological protection. This study establishes a prediction model of sea surface temperature for the next five days in the East China Sea using long-term and short-term memory neural networks (LSTM). It investigates the influence of different parameters on prediction accuracy. The sensitivity experiment results show that, based on the same training data, the length of the input data of the LSTM model can improve the model’s prediction performance to a certain extent. However, no obvious positive correlation is observed between the increase in the input data length and the improvement of the model’s prediction accuracy. On the contrary, the LSTM model’s performance decreases with the prediction length increase. Furthermore, the single-point prediction results of the LSTM model for the estuary of the Yangtze River, Kuroshio, and the Pacific Ocean are accurate. In particular, the prediction results of the point in the Pacific Ocean are the most accurate at the selected four points, with an RMSE of 0.0698 °C and an R2 of 99.95%. At the same time, the model in the Pacific region is migrated to the East China Sea. The model was found to have good mobility and can well represent the long-term and seasonal trends of SST in the East China Sea.