bluuebunny/crossref_metadata_2025 huggingface dataset:
Antimicrobial Activity of Thyme, Olive Oil, and Their Nanoemulsions Against Cronobacter Sakazakii: In Vivo Application as Natural Food Preservatives in Tallaga Cheese
Authors: Kamal Sahar Mahmoud , Elsherif Walaa Mahmoud , Valero Antonio , Faried Alshimaa Mohammed
Published: December 2024

Tallaga cheese is the most popular type of white soft cheese in Egypt. Cronobacter sakazakii is an opportunistic foodborne pathogen that poses a threat to the health of almost every age group, with a particular emphasis on neonates and infants. Essential oils (EOs), such as olive oil and thyme oil, exhibit a broad‐spectrum antibacterial effect. However, few studies have investigated the antibacterial activity of these EOs and their formulated nanoemulsions (NEs)—olive oil nano‐emulsions (ONE) and thyme oil nano‐emulsions (TNE)—on C. sakazakii in cheese to date. The purpose of this study was to investigate the inhibitory effects of these EOs and their NEs on the development of C. sakazakii during the processing and storage of Tallaga cheese. Additionally, the organoleptic properties of the resulting cheese were evaluated. Herein, ONE and TNE were prepared and characterized using a zetasizer and transmission electron microscopy (TEM). Furthermore, the minimum inhibitory concentrations (MICs) of EOs and NEs were determined using well diffusion assay. Fresh buffalo's milk for the elaboration of Tallaga cheese was inoculated with C. sakazakii at a concentration of 6 log CFU/mL, along with the addition of MICs of either EOs or NEs. The obtained results showed that the MICs were 15 mg/mL (v/v) for either olive oil, thyme oil, ONE and TNE with diameter inhibition zones of 10.3 ± 0.5, 13.3 ± 1.7, 12.3 ± 0.5, and 16 ± 0.8 mm, respectively. In addition, NEs exhibited high antibacterial activities against C. sakazakii in comparison to pure EOs. Particularly, the strongest antibacterial effect toward C. sakazakii was reported with TNE during manufacturing and storage of Tallaga cheese. Overall, these results suggest that thyme and its NEs have the potential to prevent bacterial contamination by C. sakazakii in the dairy industry.
Judicial Reform and Banks Credit Risk Exposure*
Authors: Canzian Giulia , Ferrara Antonella Rita
Published: December 2024

The aim of this paper is to examine the impact of the Judicial System Reform, which was introduced in Italy in 2012, on the efficiency of the judicial system and the exposure of banks to credit risk in terms of Non‐performing loans. To this end, we apply a difference‐in‐differences approach, using a dataset that covers annual judicial proceedings from 2010 to 2017, supplemented by bank balance sheet data. Our findings indicate that the reform had a detrimental effect on both judicial efficiency and the NPL ratio. The negative impact is especially pronounced in courts that were previously more efficient, suggesting that the court mergers may have resulted in diseconomies of scale.
Level of Information and Awareness About Colorectal Cancer and Its Screening Program in Türkiye: A Community‐Based Cross‐Sectional Study
Authors: ALPTEKİN Hatice Merve , KÜÇÜKKAYA Burcu
Published: December 2024

Objective

Colorectal cancer (CRC) has high mortality if it is detected in advanced stages, persons can lower their risk of CRC by adopting a healthy lifestyle that may lead to prevention. Screening is the most powerful public health tool to reduce mortality, considering the challenges of making substantial lifestyle changes or implementing widespread primary prevention strategies to lower the risk of CRC. This study aims to find out the levels of information and awareness about CRC and its screening program in individuals living in Türkiye.

Design

This study was a community‐based cross‐sectional.

Sample

This study was performed from November 2019 to November 2022 with a web‐based survey circulated through social media and communication platforms. The research was conducted with 4146 participants.

Measurements

The “Survey Form” was used in the data collection. Descriptive statistics and logistic regression were used in the data analysis.

Results

The study found that 43.3% of participants had information about CRC and its screening program. Among all participants, 94.7% had never undergone CRC screening, and 55.6% were aware of a CRC awareness month. The study also revealed that participants who were knowledgeable about CRC screening were more likely to have a family history of cancer, a personal history of cancer, prior awareness of CRC, and previous information about the disease. Additionally, they were more likely to have undergone CRC screening before and to believe that CRC screening is necessary.

Conclusion

It was found that the majority of participants had no information on CRC and its screening program and never underwent CRC screening before. More studies should be performed to find out the factors negatively affecting the participation of individuals in the CRC screening program
UV‐A photodegradation of vanillin in aqueous solutions: Direct photolysis and photosensitized degradation
Authors: Fernandez Heryerli , Niederst Leo , Joyeux Cécile , Allonas Xavier , Lorente Carolina
Published: December 2024

Phototoxicity of skin due to the application of skincare products or fragrances is increasing from day to day, since a lot of natural extracts, with low or no toxicity in the dark, are being used in the skin exposed to solar radiation. In particular, the use of 4‐hydroxy‐3‐methoxy benzaldehyde, known as vanillin, in the pharmaceutical, food, and cosmetic industries has increased in the last years. This compound is generally considered as safe for humans, and it has been used in a wide range of applications. Significant beneficial properties, such as antioxidant, anticancer, antimicrobial, among others, have been described for vanillin, along with low toxicity. However, although vanillin is used as an ingredient in cosmetic formulations that are applied to the skin, there are few studies on the photochemistry of vanillin degradation. The degradation of vanillin in aqueous solutions exposed to UV‐A radiation (365 nm), both by direct absorption and by means of a photosensitized mechanism, was evaluated in different experimental conditions. On the bases of the experimental results, direct photodegradation of vanillin seems unlikely; however, photosensitized degradation of vanillin was observed in the presence of pterin, and vanillin dimers (6,6‐dihydroxy‐5,5‐ dimethoxy‐[1,1‐biphenyl]‐3,3‐dicarboxaldehyde) were detected as products. The mechanistic analysis indicates that the long‐lived pterin triplet excited state is responsible of vanillin degradation, while the contribution of reactive oxygen species, such as superoxide anion, hydrogen peroxide, or singlet oxygen, is negligible. The thermodynamic feasibility of the potential reactions involved in the degradation mechanism was evaluated with the Rehm–Weller equation. Considering both the thermodynamic and kinetic evidence, we proposed a mechanism for the photosensitized degradation of vanillin.
Securing a Future in Nonmetropolitan Areas: Community and Family Influences on Young Adults' Intentions to Stay for Employment☆
Authors: Choi Ha Young , Kramer Karen Z.
Published: December 2024

This study examines how community perceptions, family‐related factors, and other psychosocial factors collectively shape young adults' intentions to stay in their nonmetropolitan communities for employment. Research on nonmetropolitan populations' intentions to stay has increasingly highlighted community factors, including perceptions of the community and social connections. However, perceptions of the community have often been studied linearly and researchers have overlooked the multidimensional nature of employment decisions. Thus, this study conducted a latent profile analysis of 513 nonmetropolitan young adults and identified four distinct profiles: positive perceptions of social and professional characteristics (38.79%), positive perceptions of overall community characteristics (35.28%), positive perceptions of long‐term life planning characteristics (15.79%), and negative perceptions of overall community characteristics (10.14%). Path analyses indicated that community perception profiles, characterized by more positive perceptions of family‐friendliness and enjoyment of an active social and professional life, are associated with greater intention to obtain or retain local employment in a nonmetropolitan community. The findings are mediated by the effects of embeddedness within a community and organization. Family support also plays a crucial role in job seekers' intentions to stay for employment. They also value their own perceptions of fewer barriers to staying in nonmetropolitan organizations. These findings provide policy implications for attracting and retaining young nonmetropolitan workers by aligning their aspirations with community, work, and social characteristics.
Introducing quantum mechanics with a two-mode Mach–Zehnder interferometer
Authors: Rey Gauthier , Mathevet Renaud , Massenot Sébastien , Chalopin Benoit
Published: December 2024

As an early teaching tool in QM, we propose to use a single-photon Mach–Zehnder interferometer. We demonstrate experimentally several properties associated with the concept of single photons in quantum optics and use them to introduce the quantum formalism and postulates in a more intuitive way.
Henipaviruses: epidemiology, ecology, disease, and the development of vaccines and therapeutics
Authors: Spengler Jessica R. , Lo Michael K. , Welch Stephen R. , Spiropoulou Christina F.
Published: December 2024

Henipaviruses were first identified 30 years ago and have since been associated with over 30 outbreaks of disease in humans. Highly pathogenic henipaviruses include Hendra virus (HeV) and Nipah virus (NiV), classified as biosafety level 4 pathogens. In addition, NiV has been listed as a priority pathogen by the World Health Organization (WHO), the Coalition for Epidemic Preparedness Innovations (CEPI), and the UK Vaccines Research and Development Network (UKVN). Here, we re-examine epidemiological, ecological, clinical, and pathobiological studies of HeV and NiV to provide a comprehensive guide of the current knowledge and application to identify and evaluate countermeasures. We also discuss therapeutic and vaccine development efforts. Furthermore, with case identification, prevention, and treatment in mind, we highlight limitations in research and recognize gaps necessitating additional studies.
Unlocking learning: exploring take-home examinations and
viva voce
examinations in microbiology education for biomedical laboratory science students
Authors: Curbo Sophie , Lindkvist Annica , Hultgren Catharina
Published: December 2024

Many educational institutions transitioned to digital distance-based learning and assessment formats in 2020 due to the severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) pandemic. This shift has often been associated with concerns about increased student cheating and heightened stress. In this study, we compared the major course assessment grades of students in a microbiology course delivered through a digital distance-based format, including a take-home examination and a
viva voce
examination during 2020, 2021, and 2022 (
n
= 127) with those who took the course in a traditional, live, in-person format with an in-class examination in 2019 (
n
= 45). Additionally, an extensive course evaluation survey was conducted to assess student satisfaction with the different course formats. In 2019, the pass rate was 27%, which increased significantly to 63% (
P
< 0.001) when provided as a distance-based course during 2020/2021/2022. The survey results indicated that most students appreciated the digital distance-based format and considered it beneficial for their learning. While some students found the take-home examination to be challenging and the
viva voce
examination stressful, others viewed the take-home examination as beneficial for their learning and the oral follow-up as a valuable opportunity for further learning. The combination of digital lectures and quizzes enabled students to learn at their own pace and convenience, which can lead to greater engagement and contribute to higher pass rates. Take-home examinations promote deeper learning as students must independently find answers to questions. When these examinations were followed by
viva voce
examinations, students were given the chance to elaborate on their responses, thereby gaining additional insights and reinforcing their learning during the examination process.
Insights into ecology, pathogenesis, and biofilm formation of
Enterococcus faecalis
from functional genomics
Authors: Willett Julia L. E. , Dunny Gary M.
Published: December 2024

Enterococcus faecalis
is a significant resident of the gastrointestinal tract of most animals, including humans. Although generally non-pathogenic in healthy hosts, this microbe is adept at the exploitation of compromises in host immune functions, resulting in life-threatening opportunistic infections whose treatments are complicated by a high degree of intrinsic and acquired resistance to antimicrobial chemotherapy. Historically, progress in enterococcal research was limited by a lack of experimental models that replicate natural infection pathways and the relevance of
in vitro
studies to the natural biology of the organism. In this review, we summarize the history of enterococcal research during the 20th and early 21st centuries and describe more recent genetic and genomic tools and screens developed to address challenges in the field. We also describe how the results of recent studies reveal the importance of previously uncharacterized enterococcal genes, and we provide examples of interesting determinants that have emerged as important contributors to enterococcal biology. These factors may also serve as targets for future vaccines and chemotherapeutic agents to combat life-threatening hospital infections.
Erratum to: Differentiation of Optical Signals Using an Integrated Metal–Dielectric–Metal Structure
Authors: Kashapov A. I. , Bezus E. A. , Bykov D. A. , Doskolovich L. L.
Published: December 2024

An Erratum to this paper has been published: https://doi.org/10.1134/S1062873824110017
Erratum to: Spatial Coherence of Exciton–Polariton Bose–Einstein Condensates
Authors: Kuznetsova N. V. , Makarov D. V. , Asriyan N. A. , Elistratov A. A. , Lozovik Yu. E.
Published: December 2024

An Erratum to this paper has been published: https://doi.org/10.1134/S1062873824110066
Haemophagocytic lymphohistiocytosis (HLH) secondary to diffuse large B-cell lymphoma: uncommon complication of a common disease
Authors: Mishra Rahul , Javed Rabia , Muganlinskaya Nargiz , Meisenberg Barry
Published: December 2024

Haemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening syndrome characterised by dysregulated immune activation, inflammation and multiorgan failure. In adults, HLH often arises secondary to an underlying trigger including infections, malignancies, autoimmune conditions, immunodeficiencies, chemotherapy or bone marrow transplantation. Diffuse large B-cell lymphoma (DLBCL) contributes to about 5–10% of malignancy-associated HLH. This case report highlights the clinical course of an elderly woman with HLH associated with DLBCL, who had an initial response in HLH with mini-R-CHOP (rituximab, cyclophosphamide, hydroxydaunorubicin, oncovin and prednisone) therapy. However, on lymphoma progression, she presented with a severe form of HLH leading to her death. This clinical scenario needs further research with the development of interventions based on the enhanced knowledge of underlying physiology.
Diving Deeper: Leveraging the Chondrichthyan Fossil Record to Investigate Environmental, Ecological, and Biological Change
Authors: Kim Sora L. , Balk Meghan A. , Sibert Elizabeth C. , Whitenack Lisa
Published: December 2024

The extensive chondrichthyan fossil record spans 400+ million years and has a global distribution. Paleontological studies provide a foundation of description and taxonomy to support deeper forays into ecology and evolution considering geographic, morphologic, and functional changes through time with nonanalog species and climate states. Although chondrichthyan teeth are most studied, analyses of dermal denticle metrics and soft tissue imprints are increasing. Recent methodological advances in morphology and geochemistry are elucidating fine-scale details, whereas large datasets and ecological modeling are broadening taxonomic, temporal, and geographic perspectives. The combination of ecological metrics and modeling with environmental reconstruction and climate simulations is opening new horizons to explore form and function, demographic dynamics, and food web structure in ancient marine ecosystems. Ultimately, the traits and taxa that endured or perished during the many catastrophic upheaval events in Earth's history contribute to conservation paleobiology, which is a much-needed perspective for extant chondrichthyans.

▪

The longevity and abundance of the chondrichthyan fossil record elucidates facets of ecological, evolutionary, and environmental histories.

▪

Though lacking postcranial, mineralized skeletons, dental enameloid and dermal denticles exquisitely preserve morphology and geochemistry.

▪

Technical advances in imaging, geochemistry, and modeling clarify the linkages between form and function with respect to physiology, diet, and environment.

▪

Conservation efforts can benefit from the temporal and spatial perspective of chondrichthyan persistence through past global change events.
The mitochondrial lactate oxidation complex: endpoint for carbohydrate carbon disposal
Authors: Leija Robert G. , Arevalo Jose A. , Xing Dianna , Vázquez-Medina José Pablo , Brooks George A.
Published: December 2024

We expand on knowledge of the architectural design of the mitochondrial lactate oxidation complex (mLOC); key members are: mitochondrial lactate dehydrogenase (mLDH), monocarboxylate transporter 1 (mMCT1), cytochrome oxidase (COx), basigin scaffolding protein (CD147), and the mitochondrial pyruvate carrier (mPC). The mLOC is key in creating the lower end of the concentration gradient for disposal of lactate and pyruvate.
Congenital Nasal Bones Agenesis: Report of a Rare Malformation
Authors: Russo Monica , Ferrecchi Chiara , Rebella Silvia , Capra Valeria , Ameli Franco , Pacetti Mattia , Di Feo Maria Francesca , De Biasio Pierangela , Arioni Cesare
Published: December 2024

Congenital arhinia and hyporhinia are rare facial anomalies whose knowledge usually comes from case reports. The severity of each case described in literature is variable; it also depends on associated malformations too. Since the newborns are obligate nasal breathers, babies with arhinia or hyporhinia usually have respiratory distress and need airway stabilization. In addition, most of these children present difficulties in feeding and this impairment must be managed early. We describe an unusual case of partial congenital arhinia, the baby did not have other anomalies or any specific complication such as respiratory and feeding issues, so the major problem was the aesthetic and psychological issues for the family. Even if the neonatal course was uncomplicated, a coordinated approach of the pediatrician with the pediatric otolaryngologist, the geneticists and the neurosurgeons was necessary because the management of these malformations is always very complex; due to the lack of reports described in literature, an univocal management and also the best timing and technique for reconstructive surgery are still not defined.
Digital Papillary Adenocarcinoma at the Site of 5 Years of Recurrent Paronychia: Case Report and Literature Review
Authors: Bernstein Ethan , Bernal Carter , Bol Brandon , Hershenhouse Jacob , Bernstein Matthew
Published: December 2024

Digital papillary adenocarcinoma (DPA) is a rare malignant eccrine tumor often misdiagnosed as a benign condition. A 57‐year‐old Caucasian male with recurrent paronychia and a subcutaneous mass on the distal phalanx of the right fourth digit was diagnosed with DPA after seeking hand surgery evaluation 5 years following onset. A marginal excisional biopsy was positive for Staphylococcus aureus infection and DPA, leading to surgical excision with transmiddle phalangeal amputation for negative margins. DPA, while rare, often presents insidiously, leading to delayed diagnosis and increased risk of metastasis. This tumor has high rates of recurrence and metastasis, most commonly to pulmonary and lymphatic sites. Accurate diagnosis of DPA is challenging due to its resemblance to multiple benign cutaneous conditions. Current treatments focus on surgical excision, with an emphasis on negative margins. Sentinel lymph node biopsy is not routinely performed, although guidelines are difficult to establish due to the rarity of DPA. Diagnosing and treating DPA minimizes metastasis and recurrence. DPA should be considered in patients presenting with recalcitrant or recurring cutaneous lesions. Surgical management remains the primary treatment strategy, with ongoing research needed to optimize treatment protocols and follow‐up care.
Enhancing Thermal Properties of Co3O4 Nanoparticles Through Optimized Mn‐Doping Concentrations
Authors: Begaw Girmaye Ambissa , Worku Ababay Ketema , Ayele Delele Worku , Yemata Temesgen Atnafu , Wubieneh Tessera Alemneh , Teshager Minbale Admas , Yihun Fantahun Aklog
Published: December 2024

Herein, a facile co‐precipitation technique was employed to prepare cobalt oxide (Co3O4) and Co3O4 nanoparticles (NPs) with manganese (Mn) doping. The morphologies and crystalline structures of the as‐prepared NPs were characterized by X‐ray diffraction (XRD), Fourier‐transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), differential thermal analysis (DTA), thermogravimetric analysis (TGA), and Brunauer–Emmett–Teller (BET) techniques. XRD measurements showed that Co3O4 (19.42 nm) and Mn‐doped Co3O4 (14.02 nm) NPs were successfully synthesized on average, and they exhibit a face‐centered cubic crystalline structure. The SEM images also depicted the spherical morphology of Co3O4 NPs, with Mn particles clustering together. FTIR spectroscopy further confirmed the presence of Mn within the doped Co3O4 NPs. TGA/DTA analysis revealed boosted thermal stability in Mn‐doped Co3O4 NPs compared to Co3O4 NPs. Moreover, the BET surface areas of Co3O4 and Mn‐doped Co3O4 NPs were 534.013 and 712.741 m2/g, respectively, indicating an increase in surface area due to Mn doping. Consequently, Mn doping enhances both surface area and thermal stability, rendering Mn‐doped Co3O4 NPs desirable for nanomaterial applications. This study shows that modulating the Mn doping concentration in the Co3O4 NPs offers superior surface area and thermal stability compared to the prepared Co3O4 NPs.
Impact of Soil and Water Conservation Measures on Soil Physicochemical Characteristics and Crop Productivity: Evidence From Korekore Watershed in the Central Highlands of Ethiopia
Authors: Fantahun Abera , Lemma Tesfaye Mebrate , Tesfay Fikrey , Getahun Yitea Seneshaw
Published: December 2024

This study investigates the effects of physical and chemical soil degradation on crop productivity in the Korekore Watershed. The watershed was categorized into level, sloping, and steep slope gradients. Within each slope gradient, one cultivated land managed with soil and water conservation and one cultivated land without soil and water conservation were selected. Selected soil physicochemical analyses were performed on 18 disturbed and undisturbed soil samples and were taken from the top 0–20 cm depths from each cultivated land with three replications. The soil degradation index (SDI) was evaluated based on the percent changes in soil properties of cultivated land without soil and water conservation to that of the cultivated land managed with soil and water conservation. The crop productivity index was determined by analyzing the percentage growth rate and its standard deviation. Soil bulk density and moisture content improved undercultivated land managed with SWC practices. Significantly higher (p ≤ 0.05) soil organic carbon (SOC) content (2.02%), total N (0.12%), available P (4.69 ppm), and exchangeable K (1.33 cmolc/kg) were observed in cultivated land managed with SWC as compared to cultivated land without SWC measures. The value of the SDI (+243.9%) for the watershed has demonstrated that soil degradation has improved and soil and water conservation measures had a significant impact on crop yields. The average crop yield rate (CYR) (30%) was found to be lower than the estimate provided by the central statistics agency in Ethiopia. A higher CYR was observed in cultivated land managed with soil and water conservation practices. It can be concluded that physical and chemical soil degradation significantly impacts crops unless counterbalanced by soil and water conservation measures. Therefore, it is recommended to implement well‐integrated watershed management practices to improve soil quality and enhance crop productivity.
Care pathway heterogeneity in Amyotrophic Lateral Sclerosis: effects of gender, age and onset
Authors: Dibling Marc , Ortholand Juliette , Salachas François , Hesters Adèle , Tezenas du Montcel Sophie
Published: December 2024

Background and objectives: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron degeneration resulting in loss of muscle function. Care management is restricted to symptomatic and palliative strategies, while clinical manifestations are heterogeneous. However, assessing the timing and benefits of ALS major clinical interventions remains challenging, with varying and nonspecific time-to-events estimates reported in the literature. Consequently, we proposed a retrospective cohort study leveraging healthcare system data to investigate ALS patients care pathway stratified by gender, age class and onset site to describe strategies diversity and temporality.
Methods: We developed an algorithm to identify incident ALS patients in the French hospitalization registry and assessed its quality through comparison with literature. We described 7 states, encompassing patient status regarding clinical intervention history, considered 15 transitions and stratified the analysis depending on 12 different patient profiles, defined according to gender, the presence of symptoms indicative of disease onset site and age class, to model profile-specific care pathway trajectories. Alongside analysis of median time before transition, we compared acceleration factors resulting from Accelerated Failure Time (AFT) and time-inhomogeneous models.
Results: We identified 21,153 incident patients with ALS between 2013 and 2022 with a mean age of 67.7±13.1 years at time of in-registry detection, male/female and spinal/bulbar ratios of 1.2 and 1.9, respectively. Non-invasive ventilation (NIV), gastrostomy, tracheostomy or death at hospital was recorded for 55.24% of the study population. We identified significant variations in utilization based on gender, age class, and onset site. Notably, older age and bulbar onset site accelerated gastrostomy use and spinal onset site was associated with delayed NIV initiation while tracheostomy, mainly considered for younger patients (<64 years), is rarely indicated in ALS care management. Alongside investigation of time-to-event speed, we report extensively the patient profile-specific estimated median delay before clinical event start.
Conclusion: Leveraging real-world data from hospital registries provides a large sample size to investigate low prevalence diseases. In conjunction with multi-state models such data enables a comprehensive analysis of care pathways which revealed variations in ALS management strategies based on patient profiles. By identifying these disparities, our study contributes to enhancing the foreseeability of support strategies for ALS patients.
Robotic-assisted surgical staging with sentinel node biopsy for apparently early-stage endometrial cancer using the modular multi-arm surgical robot system Versius® (Cambridge Medical Robots): a case series.
Authors: Uccella Stefano , Galli Liliana , Casprini Chiara , Festi Anna , Bosco Mariachiara , Zorzato Pier Carlo , Caraffini Andrea , Del Prete Biancamaria , Giacopuzzi Simone , Favilli Alessandro , Franchi Massimo , Bravi Callisto Marco , Garzon Simone
Published: December 2024

Objectives: To report the first cases of surgical staging for apparently early-stage endometrial cancer performed using the Versius® next-generation robotic surgical system (Cambridge Medical Robots [CMR] Surgical, Cambridge, UK).
Design: Prospective case series.
Participants/Materials: Women who underwent surgical staging, including total hysterectomy, bilateral adnexectomy, and sentinel lymph node (SLN) biopsy, for apparently early-stage endometrial cancer using the Versius® next-generation robotic surgical system (CMR Surgical, Cambridge, UK).
Setting: Gynecologic oncology referral center.
Methods: We prospectively recorded data of all consecutive women who underwent the investigated surgical procedure.
Results: Fourteen endometrial cancer patients were treated between March and August 2024 at the Azienda Ospedaliera Universitaria Integrata of Verona. The mean age was 69.4 ± 8.7 years, and the average body mass index was 27.2 ± 4.8. SLN biopsy was performed in all patients: 5 patients had unilateral and 9 bilateral successful SLN detection; 6 women underwent systematic pelvic lymphadenectomy in the unmapped areas. The median operative time was 122 (min-max, 77-185) minutes, and the median hysterectomy time was 34 (min-max, 18-68) minutes. None of the surgical procedures required conversion to conventional laparoscopic or open surgery for technical reasons, and no intraoperative complications were recorded. No readmissions, reoperations, or deaths were observed during the follow-up (median 102 days, min-max 39-249).
Limitations: First experience in a limited study population and use of methylene blue for SLN mapping.
Conclusions: Our preliminary results with the Versius® platform appear encouraging regarding surgical time, blood loss, rate of completion of the robotic procedures, and complications risk. Further studies will confirm the indications, feasibility, and safety of the Versius® surgical robot system for treating apparently early-stage endometrial cancer.
New insights from long-term clinical use of ctDNA-based minimal residual disease monitoring in translocation-associated sarcomas
Authors: Joch Sophie , Smolle Maria Anna , Kashofer Karl , Thüringer Andrea , Szkandera Joanna , Benesch Martin , El-Heliebi Amin , Liegl-Atzwanger Bernadette , Leithner Andreas , Seidel Markus G.
Published: December 2024

Introduction: Assessment of circulating tumor DNA (ctDNA) as means to monitor disease activity in translocation-associated tumors has become very popular in clinical practice. However, there are still few studies on its clinical application to date. Our study evaluates the clinical applicability of ctDNA as a biomarker for monitoring minimal residual disease (MRD) in patients with translocation-associated sarcomas.
Methods: In this retrospective study, we correlated 285 ctDNA samples from 34 patients diagnosed with translocation-associated sarcoma with the clinical course and images. Blood samples were collected at multiple time points during follow-up (median: 97 weeks, range: 7–398).
Results: We discovered a significant association between ctDNA levels and the clinical course of the disease, particularly noting differences between patients in remission or with progressive disease (p = 0.001). Furthermore, although we noted that ctDNA levels remained undetectable in a few cases of unilocular recurrence (n = 3), they were consistently higher in patients with multilocular recurrence (n = 14; p = 0.008).
Conclusion: Monitoring ctDNA levels provides highly specific, additional information enabling early recurrence detection in patients with translocation-associated sarcomas during the follow-up and can be integrated into clinical practice. However, MRD monitoring by ctDNA quantification alone does not allow the reliably detection of 100% of unilocular recurrences and should be complemented by the use of conventional imaging techniques.
Metabolic syndrome, non-alcoholic fatty liver disease and graft inflammation: an unaddressed pathogenic link after kidney transplantation
Authors: Fariña-Hernández Arminda , González-Rinne Ana , Hernández-Bustabad Alberto , Guerra-Rodríguez Rita María , Saiz-Udaeta Ana Paola , Alonso-Titos Juana , Marrero Domingo , Rivero-González Antonio , Santana-Quintana Cristo Adonay , Ruíz-Esteban Pedro , Hernández Domingo
Published: December 2024

Kidney transplantation (KT) is the treatment of choice for chronic kidney disease (CKD) patients, but there is a continued loss of grafts in the long-term (50% at 10 years) due to either patient 's death or chronic allograft dysfunction. Metabolic syndrome (MS) is very prevalent after KT (30-40%) and its components contribute to the appearance of non-alcoholic fatty liver disease/metabolic dysfunction-associated fatty liver disease (NAFLD/MAFLD) and non-alcoholic steatohepatitis (NASH), which represents the hepatic component of MS. Furthermore, about 20-40% of KT recipients present early graft inflammation, including subclinical inflammation. Thus, the relationship between NAFLD-MAFLD/NASH and graft inflammation may be in a bidirectional, though no definite link between NAFLD-NASH and graft inflammation is currently known. Additionally, MS-related risk factors are associated with modern immunosuppressants and negative synergistic effect on graft and patient survival seems plausible. Indeed, pro-inflammatory cytokines and adipokines released by adipose tissue can generate a low-grade inflammatory state and endothelial dysfunction both involved in the appearance of CVD, and these disorders are associated with worsening liver lesions and subclinical and clinical atheromatosis. In this review, we show the recent clinical evidence regarding the prevalence and risk factors of MS and NAFLD/MAFLD following KT. Additionally, we propose the potential mechanism link between NAFLD/MAFLD-NASH and graft inflammation post-KT, as well as alternatives therapies for NAFLD after KT. Prevention of long-term life-threatening complications in this particular population rests upon better understanding and management of these severe clinical complications.
ОСОБЛИВОСТІ ПРОВЕДЕННЯ ДОГОСПІТАЛЬНОЇ СЕРЦЕВО-ЛЕГЕНЕВОЇ РЕАНІМАЦІЇ НА ТЛІ ВИКОНАННЯ БАЗОВИХ ПОЛОЖЕНЬ СУЧАСНОГО КЛІНІЧНОГО ПРОТОКОЛУ РАПТОВОЇ ЗУПИНКИ КРОВООБІГУ
Authors: Гудима А. А. , Ляхович Р. М. , Кіцак Я. М. , Ястремська І. О.
Published: December 2024

Вступ. Відомо, що на кінцевий результат виконання розширених реанімаційних догоспітальних заходів лікарськими (парамедичними) бригадами екстреної медичної допомоги (ЕМД) впливає низка ключових факторів: часові рамки доїзду бригади до хворого (постраждалого), наявність (відсутність) домедичної допомоги і власне якість реанімаційних заходів, які на місці подій проводить бригада ЕМД. Досконале знання сучасного клінічного протоколу раптової зупинки кровообігу в кінцевому результаті здатне суттєво знизити догоспітальну летальність.
Мета роботи – провести клініко-статистичний аналіз діяльності бригад ЕМД м. Тернополя за 2021–2023 рр., які виїжджали на виклики до хворих, що перебували в стані клінічної смерті.
Основна частина. За основу досліджень було взято кількість доїздів бригад ЕМД до хворих (постраждалих) з раптовою зупинкою кровообігу за період 2021–2023 рр. Діяльність працівників ЕМД оцінювали за декількома критеріями, в основі яких були: час доїзду до місця події, швидка констатація ознак клінічної смерті у хворих (постраждалих), якість виконання розширених реанімаційних заходів з дотриманням базових положень актуального протоколу раптової зупинки кровообігу. Особливу увагу, зокрема, приділено швидкій інтерпретації виду зупинки кровообігу, своєчасній ранній дефібриляції, коректному введенню необхідних медикаментів з аналізом потенційно зворотних причин стану клінічної смерті, а саме так званих «4 Г та 4 Т». Також увагу було сфокусовано на оцінці та своєчасному й адекватному забезпеченні прохідності дихальних шляхів, у тому числі інтубації трахеї і застосуванні альтернативних до неї методів штучної вентиляції легень (постановка ларенгеальної макси, трубки тощо). Слід враховувати те, що на загальну кількість летальних випадків, головним чином, впливають: основне захворювання пацієнта, його вік, наявність супутніх патологій, а також не сумісні з життям травми.
Висновки. Дотримання новітніх алгоритмів проведення догоспітальної серцево-легеневої реанімації на тлі надання кваліфікованої домедичної допомоги – запорука зниження загальної смертності.
АНАЛІЗ НАУКОВИХ ДОСЛІДЖЕНЬ РОЗЛАДІВ СНУ ТА ТРИВОЖНОСТІ В МЕДСЕСТЕР ЗА ОСТАННІ 25 РОКІВ
Authors: Наумова Л. В. , Наумова У. О. , Зарічна О. Й. , Марченко Т. Ю.
Published: December 2024

Вступ. В останні роки все більше уваги приділяють здоров’ю медичного персоналу, адже саме від нього залежать якість догляду за пацієнтами і ретельність виконання лікарських призначень. Мед­сестри, які безпосередньо доглядають за пораненими та хворими, зазнають значних психологічних і фізичних навантажень. Однією з найбільш поширених у них проблем є розлади сну та підвищення тривожності, що можуть призвести до так званого синдрому вигорання. Ці стани впливають не тільки на здоров’я медсестер, але й на їх здатність ефективно виконувати свої професійні обов’язки.
Мета роботи – проаналізувати інформацію, наявну в наукометричній базі Scopus, щодо поширеності й актуальності такої теми, як розлади сну та тривожність у молодшого медичного персоналу, зокрема медсестер.
Основна частина. У наукометричній базі Scopus було сформульовано аналітичний запит (порушення сну в медсестер, тривожність у медсестер, чинники, що впливають на розлади сну за екстремальних умов) з метою отримання різнобічної інформації щодо цієї теми. На наш пошуковий запит з даної теми в наукометричній базі Scopus знайдено всього 2679 наукових праць, надрукованих з 1995 до 2024 р., незважаючи на її актуальність. З огляду на те, що за останні 25 років науково-технічний прогрес зробив неймовірний стрибок, навантаження на нервову систему медсестер зросло в рази, саме тому обрана тема надзвичайно актуальна. З’ясовано, що розлади сну та наявність тривожності в медсестер можуть бути спричинені різноманітними факторами, такими, як ненормований графік роботи, нічні зміни, незбалансоване харчування, гіпервідповідальність і бажання все зробити ідеально, страх втратити роботу або отримати зауваження від лікарів чи іншого медичного персоналу тощо. Проаналізовано дані за останні 25 років і показано підвищення інтересу до цієї теми, а також проаналізовано кількість публікацій, топ авторів, університетів, країн. Усі ці результати наглядно відображено в діаграмах.
Висновки. Збір і аналіз даних про розлади сну та тривожність у медсестер є ключовими для покращення їх професійного й особистого життя, що, у свою чергу, сприяє підвищенню якості медичної допомоги загалом.
Three new species of Multistria from mid-Cretaceous amber of northern Myanmar (Hemiptera: Fulgoromorpha: Mimarachnidae)
Authors: FABRIKANT DOLEV , HUANG DI-YING , FU YAN-ZHE
Published: December 2024

The extinct planthopper family Mimarachnidae is well represented in mid-Cretaceous Kachin amber of northern Myanmar. In this study, three new species of mimarachnid planthoppers are described and illustrated from Kachin amber, all belonging to the genus Multistria Zhang, Yao & Pang, 2021. The new species, Multistria irregularis sp. nov., M. juanae sp. nov., and M. fionae sp. nov., are primarily distinguished from each other mostly by tegminal characters, such as the branching pattern of the secondary veinlet meshwork, venation, and the colour patterns, as well as differences in head. The tegminal diagnostic characters of Multistria are briefly examined.
Neoribates (Neoribates) subiasi sp. nov. (Acari, Oribatida, Parakalummidae) from Changbai Mountain, China
Authors: YU BIXIAO , PAN XUE , LIU DONG
Published: December 2024

A new species of oribatid mites of the subgenus Neoribates (Neoribates) (Oribatida, Parakalummidae) is described from the litter of Changbai Mountain in northeastern China. Neoribates (Neoribates) subiasi sp. nov. differs from its congeners by the combination of the morphological traits, e.g. smooth body surface, short bothridial setae with oval-shaped head, rostrum narrowly rounded in dorsal view, 11 pairs of notogastral setae, five pairs of genital setae, and setae ad3 inserted laterally and distanced from anal aperture. A key to all known species of Neoribates in China is provided.
Two new species of the genus Allosuctobelba (Acari, Oribatida, Suctobelbidae) from China
Authors: ZHENG LI-HAO , DUAN HONG-BIN , CHEN JUN
Published: December 2024

Two new species of the genus Allosuctobelba, A. (Allosuctobelba) polita sp. nov. and A. (A.) subiasi sp. nov., are proposed and described based on adult material collected from central China.
A new species of Rostrozetes (Acari: Oribatida: Haplozetidae) from Brazil
Authors: BOMFIM GRECILANE S. , DELABIE JACQUES H.C. , OLIVEIRA ANIBAL R.
Published: December 2024

The mite Rostrozetes achilles sp. nov. is described from adult specimens collected from nests of the ant Camponotus cingulatus (Formicidae) in dry cacao pods and the surrounding soil–litter interface in a cacao plantation of Ilhéus, state of Bahia, northeastern Brazil. This is the sixth Rostrozetes species known to have heteromorphic notogastral setae. The species name refers to the apparent use of its laminar discidium to protect its ‘heel’, the joint between tarsus and pretarsus, during leg IV flexion. Other possible functions for it are also discussed.
A new species of the genus Paralycus Womersley, 1944 (Acari, Oribatida, Pediculochelidae) from Shikoku-island, Japan
Authors: OSHIMA MASAHARU , SHIMANO SATOSHI
Published: December 2024

A new oribatid mite species, Paralycus subiasi sp. nov., is described based on morphological observation of the private collection of Professor Emeritus Minoru Shiba. This new species was found in moss and is characterized by four pairs of genital setae, the absence of epimeral seta 4a, and trochanteral setation 0-0-0-0. This is the third species of Paralycus from Japan. An updated identification key for the genus Paralycus is also provided.
A new species of Galumnella (Acari, Oribatida, Galumnellidae) from Vietnam
Authors: KOLESNIKOV VASILIY B. , LEONOV VLADISLAV D.
Published: December 2024

The article describes a new species, Galumnella subiasi sp. nov., from Vietnam, which is distinguished from others by the following combination of characteristics: the notogaster, pteromorphs, prodorsum, and ventral shield have a network pattern; there is an interlamellar ridge on the prodorsum; lamellar and sublamellar lines are parallel; rostral and lamellar setae of medium length; bothridial setae slightly expanded in the middle, unilaterally heavily spinose; notogaster with 10 pairs of short setae; the adanal setae ad3 are located anterior to the anal aperture; postanal porose area absent; all leg tarsi with three claws. An identification key is provided for all Asian species of Galumnella, and it is demonstrated that Galumnella angustifrons and Galumnella nipponica are distinct species.
A new arenicolous species of the genus Thyreophagus (Acari: Acaridae) from the Caspian sea coast: Taxonomy and ecological insights
Authors: KOLESNIKOV VASILIY B. , KLIMOV PAVEL B. , KHAUSTOV ALEXANDER A. , PEPATO ALMIR , MAKAROVA OLGA L.
Published: December 2024

A new sexual species, Thyreophagus subiasi sp. nov., inhabiting wet sands of the coastal zone of the Caspian Sea (Republic of Dagestan, Russia) is described. The new species is morphologically similar to Th. athiasae from Morocco (types redescribed here as well) but differs from it by the shape of the spermatheca and setae p and q on tarsi I–II represented by small triangular rudiments. As most other species of Thyreophagus inhabit subcortical habitats or stored food, Th. subiasi exhibits unusual ecology. We suggest that its elongated and flexible body may have facilitated adaptation to life in interstitial spaces among particles in coastal sandy environments. In this habitat, Th. subiasi co-occurred with long-bodied mesostigmatic mites from the genera Protogamasellus, Gamasellodes, and Neojordensia, suggesting that these mites are part of the coastal interstitial ecosystem.
Free-living predatory cheyletid mites (Acariformes: Cheyletidae) from Cat Tien National Park, Vietnam
Authors: KHAUSTOV ALEXANDER A. , SALAVATULIN VLADIMIR M. , TSURIKOV SERGEY M. , THINH NGUYEN VAN , KHAUSTOV VLADIMIR A.
Published: December 2024

The free-living predatory mites of the family Cheyletidae of the Cat Tien National Park (Vietnam) are reviewed. Females of two monotypic genera, Vietocheyla subiasi gen. and sp. nov., Paracheletogenes mirabilis gen. and sp. nov., and all active stages of a new species Cheletogenes vietnamiensis sp. nov. are described. Four species, Cheletomimus (Hemicheyletia) bakeri (Ehara, 1962), Ch. (H.) gracilis Fain, Bochkov and Corpuz-Raros, 2002, Ch. (H.) chui (Tseng, 1977), and Tutacheyla robusta Corpuz-Raros, 1972 are recorded from Vietnam for the first time.
Taxonomic contribution to knowledge of the oribatid mite genus Tritegeus (Acari, Oribatida, Cepheusidae)
Authors: ERMILOV SERGEY G.
Published: December 2024

A supplementary description of the type species of the genus Sphodrocepheus (Oribatida, Cepheusidae) —S. tridactylus—is presented, based on adults collected from the U.S.A. The taxonomic status of Sphodrocepheus is discussed, resulting in the following new taxonomic proposal: Tritegeus Berlese, 1913 (=Sphodrocepheus Woolley & Higgins, 1963 syn. nov.). A new species of Tritegeus—T. luissantossubiasi sp. nov.—is described, based on adults from India. A supplementary description of Tritegeus mitratus is presented, based on adults collected from Japan. The new generic diagnosis and an identification key to the known 11 species of Tritegeus are provided.
Taxonomic contribution to the knowledge of the genus Indoribates and Lauritzenia (Acari, Oribatida, Haplozetidae), with description of a new species from China
Authors: XU SHU-JING , LIU CHENG-LIN , CHEN JUN
Published: December 2024

Oribatid species from China of the genus Indoribates and Lauritzenia are studied, with description of a new species Indoribates (Indoribates) subiasi sp. nov. based on adult materials collected from China. Indoribates (I.) japonicus (Aoki, 1988), I. (Haplozetes) vindobonensis curtipilis (Kunst, 1977), and Lauritzenia (Incabates) nuda (Hammer, 1961), are recorded in China for the first time. A new combination is proposed: Lauritzenia (Incabates) nobilis (Golosova, 1984) comb. nov. (from the genus Cosmobates Balogh, 1959). Two new synonyms are proposed: Indoribates (Haplozetes) vindobonensis curtipilis (= Haplozetes ulykpani Bayartogtokh & Aoki, 1998 syn. nov.) and Indoribates (Indoribates) Jacot, 1929 (= Indoribates (Bihaplozetes) Subías, 2020 syn. nov.). A key to the known species of Indoribates and Lauritzenia from China is also provided.
New species of Scapheremaeus (Acari: Oribatida: Cymbaeremaeidae) from an epiphytic environment in Morelos, Mexico
Authors: PALACIOS-VARGAS JOSÉ G. , MURILLO KEVIN A. JAIMES , OJEDA MARGARITA
Published: December 2024

Scapheremaeus subiasi sp. nov. from El Zapote, Morelos is described and illustrated. It is morphologically similar to other Mexican species living in moss and lichens, i.e. S. magdalenae and S. hectorperezius, in sharing the presence of a humeral process, body ornamentation, number of notogastral setae (10) and being monodactylous. Main differences include body size, well developed lamellar tubercles and general appearance of the posterior end of notogaster. In addition, an identification key for all known Mexican species in the genus is given.