bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeting cell adhesion molecules with nanoparticles usingin vivoand flow-basedin vitromodels of atherosclerosis
Authors: Khodabandehlou Khosrow , Masehi-Lano Jacqueline J , Poon Christopher , Wang Jonathan , Chung Eun Ji
Published: February 2017

Atherosclerosis is a leading cause of death worldwide; in addition to lipid dysfunction, chronic arterial wall inflammation is a key component of atherosclerosis. Techniques that target cell adhesion molecules, which are overexpressed during inflammation, are effective methods to detect and treat atherosclerosis. Specifically, research groups have identified vascular cell adhesion molecule-1, intercellular adhesion molecule-1, platelet endothelial cell adhesion molecule, and selectins (E-selectin and P-selectin) as correlated to atherogenesis. In this review, we discuss recent strategies both in vivo and in vitro that target cell adhesion molecules. First, we discuss peptide-based and antibody (Ab)-based nanoparticles utilized in vivo for diagnostic, therapeutic, and theranostic applications. Second, we discuss flow-based in vitro models that serve to reduce the traditional disadvantages of in vivo studies such as variability, time to develop the disease, and ethical burden, but preserve physiological relevance. The knowledge gained from these targeting studies can be translated into clinical solutions for improved detection, prevention, and treatment of atherosclerosis.

Impact statement

As atherosclerosis remains the leading cause of death, there is an urgent need to develop better tools for treatment of the disease. The ability to improve current treatments relies on enhancing the accuracy of in vitro and in vivo atherosclerotic models. While in vivo models provide all the relevant testing parameters, variability between animals and among models used is a barrier to reproducible results and comparability of NP efficacy. In vitro cultures isolate cells into microenvironments that fail to take into account flow separation and shear stress, which are characteristics of atherosclerotic lesions. Flow-based in vitro models provide more physiologically relevant platforms, bridging the gap between in vivo and 2D in vitro models. This is the first review that presents recent advances regarding endothelial cell-targeting using adhesion molecules in light of in vivo and flow-based in vitro models, providing insights for future development of optimal strategies against atherosclerosis.
A data forwarding algorithm based on Markov thought in underwater wireless sensor networks
Authors: Li Dongwei , Du Jingli , Liu Linfeng
Published: February 2017

The underwater wireless sensor networks composed of sensor nodes are deployed underwater for monitoring and gathering submarine data. Since the underwater environment is usually unpredictable, making the nodes move or be damaged easily, such that there are several vital objectives in the data forwarding issue, such as the delivery success rate, the error rate, and the energy consumption. To this end, we propose a data forwarding algorithm based on Markov thought, which logically transforms the underwater three-dimensional deployment model into a two-dimensional model, and thus the nodes are considered to be hierarchically deployed. The data delivery is then achieved through a “bottom to top” forwarding mode, where the delivery success rate is improved and the energy consumption is reduced because the established paths are more stable, and the proposed algorithm is self-adaptive to the dynamic routing loads.
Ventriculoportal Shunt, a New Transomphalic Extraperitoneal Surgical Technique in Treatment of Hydrocephalus
Authors: Grigorean Valentin Titus , Sandu Aurelia Mihaela , Popescu Mihai , Strambu Victor
Published: February 2017

Aim. The aim of this article was to report a new transomphalic extraperitoneal surgical technique for treatment of hydrocephalus, called ventriculoportal shunt. Materials and Methods. We performed ventriculoportal shunt on an experimental animal (pig). The particularity of ventriculoportal shunt consists in the fact that the distal end of the catheter is inserted transomphalic extraperitoneally in the portal system through reopened umbilical vein. We present technical details regarding this new surgical technique. Results and Discussion. The animal had favorable outcome, without any postoperative early or late morbidity. We discuss indications, contraindications, possible complications in humans and advantages of ventriculoportal shunt compared with ventriculocardiac and ventriculoperitoneal drainages and possibilities to avoid complications specific to classic shunt procedures. Conclusions. Ventriculoportal shunt is a new surgical technique for treatment of hydrocephalus. The distal end of the catheter introduced into reopened umbilical vein, drains cerebrospinal fluid into the portal system. Ventriculoportal shunt is safe and easy to perform. With ventriculoportal shunt specific complications of ventriculoperitoneal or ventriculocardiac drainages can be potentially avoided. Ventriculoportal shunt combines advantages of vascular shunt with those of having an immunological barrier for cerebrospinal fluid before entering the systemic circulation. Theoretically, indications for surgery are extended, and ventriculoportal shunt can be performed in patients former contraindicated for ventriculoperitoneal shunt. Further research is needed and this surgical technique must be performed on human subjects with hydrocephalus.
Activations of muscarinic M1 receptors in the anterior cingulate cortex contribute to the antinociceptive effect via GABAergic transmission
Authors: Koga Kohei , Matsuzaki Yu , Honda Kenji , Eto Fumihiro , Furukawa Tomonori , Migita Keisuke , Irie Keiichi , Mishima Kenichi , Ueno Shinya
Published: February 2017

Background

Cholinergic systems regulate the synaptic transmission resulting in the contribution of the nociceptive behaviors. Anterior cingulate cortex is a key cortical area to play roles in nociception and chronic pain. However, the effect of the activation of cholinergic system for nociception is still unknown in the cortical area. Here, we tested whether the activation of cholinergic receptors can regulate nociceptive behaviors in adult rat anterior cingulate cortex by integrative methods including behavior, immunohistochemical, and electrophysiological methods.

Results

We found that muscarinic M1 receptors were clearly expressed in the anterior cingulate cortex. Using behavioral tests, we identified that microinjection of a selective muscarinic M1 receptors agonist McN-A-343 into the anterior cingulate cortex dose dependently increased the mechanical threshold. In contrast, the local injection of McN-A-343 into the anterior cingulate cortex showed normal motor function. The microinjection of a selective M1 receptors antagonist pirenzepine blocked the McN-A-343-induced antinociceptive effect. Pirenzepine alone into the anterior cingulate cortex decreased the mechanical thresholds. The local injection of the GABAA receptors antagonist bicuculline into the anterior cingulate cortex also inhibited the McN-A-343-induced antinociceptive effect and decreased the mechanical threshold. Finally, we further tested whether the activation of M1 receptors could regulate GABAergic transmission using whole-cell patch-clamp recordings. The activation of M1 receptors enhanced the frequency of spontaneous and miniature inhibitory postsynaptic currents as well as the amplitude of spontaneous inhibitory postsynaptic currents in the anterior cingulate cortex.

Conclusions

These results suggest that the activation of muscarinic M1 receptors in part increased the mechanical threshold by increasing GABAergic transmitter release and facilitating GABAergic transmission in the anterior cingulate cortex.
Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn
Authors: Todd Andrew J
Published: February 2017

The spinal dorsal horn receives input from primary afferent axons, which terminate in a modality-specific fashion in different laminae. The incoming somatosensory information is processed through complex synaptic circuits involving excitatory and inhibitory interneurons, before being transmitted to the brain via projection neurons for conscious perception. The dorsal horn is important, firstly because changes in this region contribute to chronic pain states, and secondly because it contains potential targets for the development of new treatments for pain. However, at present, we have only a limited understanding of the neuronal circuitry within this region, and this is largely because of the difficulty in defining functional populations among the excitatory and inhibitory interneurons. The recent discovery of specific neurochemically defined interneuron populations, together with the development of molecular genetic techniques for altering neuronal function in vivo, are resulting in a dramatic improvement in our understanding of somatosensory processing at the spinal level.
Emotions and prosocial behaviours: A study of the effectiveness of shocking charity campaigns
Authors: Albouy Jeanne
Published: February 2017

This article analyses the effect of negative emotions and empathy generated by emotional charities’ campaigns on several indicators of advertising effectiveness. The results show that in the context of prosocial behaviours, negative emotions elicited by the campaign enhance the persuasion and this effect is partly transmitted by the empathic response. In addition, three cognitive variables (efficacy of the solution, self-efficacy and cause involvement) interact with negative emotions through a moderated mediation process. The implications of these results that contrast with the literature are then discussed.
Interpersonal Problems and Negative Affect in Borderline Personality and Depressive Disorders in Daily Life
Authors: Hepp Johanna , Lane Sean P. , Carpenter Ryan W. , Niedtfeld Inga , Brown Whitney C. , Trull Timothy J.
Published: February 2017

Theories of Borderline Personality Disorder (BPD) suggest that interpersonal problems in BPD act as triggers for negative affect and, at the same time, are a possible result of affective dysregulation. Therefore, we assessed the relations between momentary negative affect (hostility, sadness, fear) and interpersonal problems (rejection, disagreement) in a sample of 80 BPD and 51 depressed outpatients at six time points over 28 days. Data were analyzed using multivariate multilevel modeling to separate momentary-, day-, and person-level effects. Results revealed a mutually reinforcing relationship between disagreement and hostility, rejection and hostility, and rejection and sadness in both groups at the momentary and day level. The mutual reinforcement between hostility and rejection/disagreement was significantly stronger in the BPD group. Moreover, the link between rejection and sadness was present at all three levels of analysis for the BPD group, whereas it was localized to the momentary level in the depressed group.
Integrating phosphoproteomics into the clinical management of prostate cancer
Authors: Cheng Larry C. , Tan Victor M. , Ganesan Shridar , Drake Justin M.
Published: February 2017

Phosphoproteomic analysis of tumor samples has the potential to uncover significant insights into kinase signaling networks present in late stage prostate cancer that are complementary to genomic and transcriptomic approaches. Phosphoproteomics could potentially aid drug development in clinical trial design as well as provide utility for oncologists in the personalized therapeutic management of individual cancers through identifying novel biomarkers and druggable targets. Rapid advancement of targeted mass spectrometry platforms is underway to integrate phosphoproteomic technology with genomic assays to soon translate this information into the cancer clinic.
Group-Wide, Prospective Study of Ototoxicity Assessment in Children Receiving Cisplatin Chemotherapy (ACCL05C1): A Report From the Children’s Oncology Group
Authors: Knight Kristin R. , Chen Lu , Freyer David , Aplenc Richard , Bancroft Mary , Bliss Bonnie , Dang Ha , Gillmeister Biljana , Hendershot Eleanor , Kraemer Dale F. , Lindenfeld Lanie , Meza Jane , Neuwelt Edward A. , Pollock Brad H. , Sung Lillian
Published: February 2017

Purpose

Optimal assessment methods and criteria for reporting hearing outcomes in children who receive treatment with cisplatin are uncertain. The objectives of our study were to compare different ototoxicity classification systems, to evaluate the feasibility of including otoacoustic emissions and extended high frequency audiometry, and to evaluate a central review mechanism for audiologic results for cisplatin-treated children in the cooperative group setting.

Patients and Methods

Eligible participants were 1 to 30 years, with planned cisplatin-containing treatment. Hearing evaluations were conducted at baseline, before each cisplatin cycle, and at the end of therapy. Audiologic results were assessed and graded by the testing audiologist and by two central review audiologists using the American Speech-Language-Hearing Association Ototoxicity Criteria (ASHA), Common Terminology Criteria for Adverse Events, version 3.0 (CTCAE), and Brock Ototoxicity Grades (Brock). One central reviewer also used the International Society of Pediatric Oncology Ototoxicity Scale (SIOP).

Results

At the end of treatment, the prevalence of any degree of ototoxicity ranged from 40% to 56%, and severe ototoxicity ranged from 7% to 22%. Compared with CTCAE, SIOP detected significantly more ototoxicity ( P = .004), whereas Brock criteria detected significantly fewer patients with any or severe ototoxicity ( P < .001 for both). SIOP detected ototoxicity earlier than did the other scales. Agreement between the central reviewers and the institutional audiologist was almost perfect for ASHA and Brock, whereas the poorest agreement occurred with CTCAE.

Conclusion

The SIOP scale may be superior to ASHA, Brock, and CTCAE scales for classifying ototoxicity in pediatric patients who were treated with cisplatin. Future studies should evaluate inter-rater reliability of the SIOP scale.
Nipped-A regulates intestinal stem cell proliferation in Drosophila
Authors: Tauc Helen Marie , Tasdogan Alpaslan , Meyer Patrick , Pandur Petra
Published: February 2017

Adult stem cells uphold a delicate balance between quiescent and active states, a deregulation of which can lead to age-associated diseases such as cancer. In Drosophila, intestinal stem cell (ISC) proliferation is tightly regulated and mis-regulation is detrimental to intestinal homeostasis. Various factors are known to govern ISC behavior; however, transcriptional changes in ISCs during aging are still unclear. RNA sequencing of young and old ISCs newly identified Nipped-A, a subunit of histone acetyltransferase complexes, as a regulator of ISC proliferation that is upregulated in old ISCs. We show that Nipped-A is required for maintaining the proliferative capacity of ISCs during aging and in response to tissue-damaging or tumorigenic stimuli. Interestingly, Drosophila Myc cannot compensate for the effect of the loss of Nipped-A on ISC proliferation. Nipped-A seems to be a superordinate regulator of ISC proliferation, possibly by coordinating different processes including modifying the chromatin landscape of ISCs and progenitors.
Joint Loading in Runners Does Not Initiate Knee Osteoarthritis
Authors: Miller Ross H.
Published: February 2017

Runners do not have a greater prevalence of knee osteoarthritis (OA) than nonrunners. The hypothesis that joint loads in running do not cause OA is forwarded. Two mechanisms are proposed: 1) cumulative load, which is surprisingly low in running, is more important for OA risk than peak load, and 2) running conditions cartilage to withstand the mechanical stresses of running.
THE NORDIC LEGAL FAMILY AND UNIFICATION OF LAWS
Authors: Хассельбальк Оле , Khasselbalk Ole
Published: February 2017

In the presented article the author analyses the particular and typical legal characteristics of the so-called Nordic Legal Family, which enable it to be rather specific and to be on the contrary to the Romano-Germanic legal family and the Anglo-Saxon legal families of Europe. The author emphasizes that these characteristics of Nordic legal family serve the cause of the harmonization of the laws and even legal systems of the States of Northern Europe included in this legal family. The author examines the ethnic, historical and cultural origins, the foundations of the origin of this legal family, and based on them factors that contribute to the harmonization of their laws. The specifics of the formation of legal systems of the States of this region were shown in present article. The author describes the traditional North-European countries forms and methods of legal unification through meetings and consultations of their representatives, through their joint activities, their activities in the Northern Council which is an international body of inter-parliamentary cooperation, and the Council of Ministers of Nordic Council member states whish is responsible for intergovernmental cooperation. There also were presented the examples of positive results of this unification. However, the author correlates the operation of the Nordic legal family and the negative influence of the European law.
Local Market Characteristics and Online-to-Offline Commerce: An Empirical Analysis of Groupon
Authors: Li Hui , Shen Qiaowei , Bart Yakov
Published: February 2017

We investigate the factors that affect the growth of Groupon, the leading online daily deals platform. We concentrate on the online-to-offline (O2O) aspect of the business that differentiates it from other e-commerce platforms—its strong connection to local markets. We focus on travel cost and store density, the key local characteristics that affect consumer deal demand and merchant deal offering. Using a comprehensive longitudinal data set on deal offerings and sales across local markets, and combining it with local market characteristics, we estimate a simultaneous equation model of the weekly number of deal offerings and deal sales characterizing the two-sided nature of the platform. We find that the word-of-mouth effect on the consumer side and the observational learning effect on the merchant side contribute to and reinforce the expansion of a two-sided platform. However, a larger number of deals intensifies the competition, which then lowers per deal sales and limits the number of deal offerings. We find that local characteristics have significant impact on both the deal demand and the supply side. We further use model simulation to show how differences in growth patterns across markets may be driven by local characteristics, and we decompose their relative impact on the demand and supply sides. The paper provides managerial implications for firms specializing in O2O commerce.

This paper was accepted by Matthew Shum, marketing.
Assessment of hand-washing habits among school students aged 6–18 years in Jordan
Authors: ALBashtawy Mohammed
Published: February 2017

Appropriate hand-washing practice with an adequate level of frequency is an essential skill for leading healthy lives. A cross-sectional, school study was conducted over a period of 3 months (October-December, 2016). The participants were students from grade 1 to grade 12, randomly chosen from 14 public schools in Jordan. Complete data regarding their hand-washing habits was obtained. The Pearson chi-square test was computed. Odds ratio was calculated with a 95% confidence interval to show the effect size and the strength of relationship between variables. The findings showed that the majority of the students (97.5%) washed their hands with water, and nearly 70% of them used soap. Furthermore, the majority washed their hands after using the toilet (86.7%) and after touching rubbish (84.4%). Reasons for not washing their hands from the students' perspective included: ‘no need’ (70.8%) and ‘the hand-washing facilities were not clean’ (62.3%). The findings revealed that a low percentage of school students ignored hand-washing after different critical situations, this figure decreased with age. However, the practice should be improved further. Health promotion programmes should be implemented for students and their families in the community or in school settings.
Sex and relationships education: Meeting students' needs
Authors: Hallgarten Lisa
Published: February 2017

Young people know what they want from sex and relationships education and that's a good place to start, explains the Sex Education Forum's Lisa Hallgarten.
Treatment of shepherd's crook deformity in patients with polyostotic fibrous dysplasia using a new type of custom made retrograde intramedullary nail: A technical note
Authors: Hefti F. , Donnan L. , Krieg A. H.
Published: February 2017

Aims

The severe form of coxa vara, the ‘shepherd's crook deformity’, is always a consequence of a locally extensive form of polyostotic fibrous dysplasia (or McCune-Albright syndrome). Treatment of this deformity is a challenge. The soft bone does not tolerate any implant that depends on the stability of the cortical bone (like plates or external fixators). Intramedullary nails are the most appropriate implants for stabilisation, but if they are inserted from the greater trochanter, they cannot correct the varus deformity enough.

Patients and Methods

We have developed a special intramedullary nail that can be inserted from the osteotomy site and can be driven retrograde into the femoral neck in an appropriate valgus position. We have operated 15 legs in 13 patients. The average age at surgery was 14 years and 5 months (6 to 28.9). In all, 11 femora had been operated before (unsuccessfully) with various implants.

Results

The average follow-up was 54.2 months (7 to 132). The average correction of the neck/(distal) shaft angle was 57.5° (10° to 80°) (= 72.8%). While pre-operatively none of the patients was able to walk without aid, at follow-up only one patient was unable to walk, three used the aid of crutches because of tibial lesions and one patient had an increased external rotation of the leg. At follow-up, most patients were free of pain. One implant broke and had to be replaced.

Conclusion

This new operative method offers the possibility of efficient correction and stabilisation of this severe and difficult deformation.
Effect of thickness Type on Transparent TiO2 as the Working Electrode of Dye sensitized Solar Cell (DSSC) for Solar Windows Applications
Authors: Dewi Nadya Aruma , Nurosyid Fahru , Supriyanto Agus , Suryana Risa
Published: February 2017

 

Senditized Dye Solar Cells (DSSC) consist of photoelectrode, dye, electrolyte and counter electrode which is one of the photochemical electric cells. In this article will discuss the influence of the thickness of the electrode on the electrical properties. Electrodes made by screen printing method. Screen by type T-49. TiO2 deposited on the FTO variation of the number of layers to obtain a thickness of 1, 2, 3 and 4. DSSC tested thickness by Screen Electron Microscopy (SEM), absorbance test by UV Visible Lambda 25 and characterization of current and voltage test by Keithley Measurenment 2602A. The test results showed the thickness of the TiO2 electrode thickness (1.5 ± 0.2) μm, (2.9 ± 0.5) μm, (3.5 ± 0.6) μm, and (4.5 ± 0.8 ) μm. Based on the test results absorbance maximum value contained in thickness (4.5 ± 0.8) μm having a dye adsorbed at most and have the highest efficiency  2.41%.

 
STRUCTURE MODELLING OF SUBSURFACE BY USING KIRCHHOFF MIGRATION METHOD AND FINITE DIFFERENCE ANISOTROPY METHOD
Authors: Kurniawan Husni Cahyadi , Susilo Adi , Suroso Teguh
Published: February 2017

The image of subsurface with a migration method keeps on developing to get an image result which the closest in real condition. The conditions in subsurface are very complex and variables it couses the process of wave  propagation which can not be judged as the same in every layers. so it is needed an anisotropy pharameter analysiz (η) in seismic data migration process. The research will compare two kinds of migrations those are Kirchhoff migration and finite difference anisotropy. It is done because not all datas are processed by anisotropy, even with isotropi it will get good result. The result of kirchoff migration has not so good quality (low resolution) on the first layer reflector.but on the second and third layer reflector have good result (high resolution). I estimate that in the first layer reflector there is anistropi influence, because the ratio effect between far offset and the depth is hight. The analysis result get η ansotropi pharameter result as 0,25 and put into migration process. On the second migration process is finite difference anisotropy appears on the first layer reflector and shows high resolution and suitable with the real layer model.
Gait Analysis Study of Runner Using Force Plate
Authors: Catherine Flaviana , Suryantari Risti
Published: February 2017

Humans do regular physical activities such as running. Gait is forward  propulsion of the human body using lower extremities as a thrust. Humans gait pattern is characterized by their limbs movement in terms of velocity, ground reaction force, work, kinetic energy and potential energy cycle . Human gait analysis is used to assess, to plan, and to deliver the treatment for individuals based on the conditions that affect their ability to move. Gait analysis is commonly used in running sport to improve the efficiency of athletes in running and to identify problems related to their posture or movement. The aim of this research is to do running gait analysis study of human, using force plate which equipped by track board. The benefit of this study is to provide information, ideas and new perspectives about running and its prevention over an injury. The main method that will be discussed in this study is system design of gait analysis with specific setting, hardware and software, in order to acquire data(s). 
Social Constructionism and the Role of the Unconscious in Hypnotic Responding: A Single Case Experiment
Authors: Fourie David P.
Published: February 2017

There seems to be wide acceptance by both professionals and lay people that hypnotic and especially hypnotherapeutic responding is based on the long-standing but still hypothetical dichotomy between the conscious and unconscious minds. In this simplistic view, hypnotic suggestions are considered to bypass consciousness to reach the unconscious mind, there to have the intended effect. This article reports on a single-case experiment investigating the involvement of the unconscious in hypnotherapeutic responding. In this case the subject responded positively to suggestions that could not have reached the unconscious, indicating that the unconscious was not involved in such responding. An alternative view is proposed, namely that hypnotherapeutic responding involves a cognitive process in which a socially constructed new understanding of the problem behaviour and of hypnosis, based on the client's existing attribution of meaning, is followed by action considered appropriate to the new understanding and which then confirms this understanding, leading to behaviour change.
On the Fusion of Lidar and Aerial Color Imagery to Detect Urban Vegetation and Buildings
Authors: Bandyopadhyay Madhurima , van Aardt Jan A.N. , Cawse-Nicholson Kerry , Ientilucci Emmett
Published: February 2017

Three-dimensional (3D) data from light detection and ranging (lidar) sensor have proven advantageous in the remote sensing domain for characterization of object structure and dimensions. Fusion-based approaches of lidar and aerial imagery also becoming popular. In this study, aerial
color (RGB) imagery, along with co-registered airborne discrete lidar data were used to separate vegetation and buildings from other urban classes/cover-types, as a precursory step towards the assessment of urban forest biomass. Both spectral and structural features
such as object height, distribution of surface normals from the lidar, and a novel vegetation metric derived from combined lidar and RGB imagery, referred to as the lidar-infused vegetation index (LDVI) were used in this classification
method. The proposed algorithm was tested on different cityscape regions to verify its robustness. Results showed a good separation of buildings and vegetation from other urban classes with on average an overall classification accuracy of 92 percent, with a kappa statistic of 0.85. These results
bode well for the operational fusion of lidar and RGB imagery, often flown on the same platform, towards improved characterization of the urban forest and built environments.
The Republic of Ecuador
Authors: Mugnier Clifford J.
Published: February 2017

The Grids & Datums column has completed an exploration of
every country on the Earth. For those who did not get to enjoy this
world tour the first time, PE&RS is reprinting prior articles from
the column. This month's article on the Republic of Ecuador was
originally printed in 1999 but contains updates to their coordinate
system since then.
Recursos gramaticales de opinión en el ensayo académico de estudiantes de Enseñanza de Lenguas
Authors: Hernández Ramírez Laura Aurora
Published: February 2017

Con el interés de contribuir a la caracterización de la escritura de los estudiantesdentro de las diversas áreas de la educación superior, el siguiente artículo presentaun breve análisis de las etapas funcionales y de algunos rasgos interpersonales deposicionamiento hallados en las conclusiones de una muestra de ensayos expositivo–argumentativos elaborados por estudiantes de enseñanza de lenguas en la UniversidadAutónoma de Tlaxcala. Mediante el conocimiento de estos rasgos, se busca reconocerlos recursos ya presentes en el registro académico de su disciplina de los escritoresnóveles mexicanos en un entorno de universidad pública y, con ello, tener bases mássólidas en la planeación de las acciones pedagógicas en torno a la escritura académicadentro de las instituciones de educación superior.
The effect of macro economy, liquidity, and profitability on investment risk in companies listed on the Jakarta Islamic Index (JII)
Authors: Anggrainy Malia
Published: February 2017

The economic crisis in Indonesia had an impact on the declining performance of the company’s fundamental in the stock market. Investment is the placement of funds at this time for making a profit in the future. Investment is always associated with return and risk. Investors are willing to accept greater risks but should also be compensated by the opportunity to get greater return. This research aims to find the effect of infla-tion, interest rate, and the exchange rate that represent the macro-factors and the level of liquidity and profitability (ROA) of the company that represent micro-factors ont the risk of stocks investment in companies listed on the Jakarta Islamic Index (JII). The sample used is 13 companies using purposive sampling techniques. The statistical analysis of this research is done by using multiple regression analysis. The results show that inflation rate, exchange rate, and liquidity do not have significant effect on investment risk, while interest rate and profitability have significant effect on invest-ment risk.
The effect of accrual earnings management, using Khotari Model Approach, on the performance of manufacturing companies listed in Indonesia Stock Exchange
Authors: Handoko Mochamad , Ahmar Nurmala
Published: February 2017

The purpose of this study is (1) to analyze the effect of accrual earnings management on the company performance measured with Return On Assets (ROA), (2) to analyze the effect of accrual earnings management on the company performance measured with Tobin’s Q. This study uses the data of manufacturing companies listed in Indonesia Stock Exchange. The sampling technique used is purposive sampling method. The researcher uses Khotari Model to calculate discretionary accruals as the proxy of earn-ing management, while the company performance in this study is proxied by the indi-cators of Return on Assets (ROA) and Tobin’s Q. The analysis technique used is descriptive analysis and simple linear regression. The results of this study prove that accrual earnings management affects ROA and Tobin’s Q. This study also proves that there is a decline in market value when the earnings management is performed.
The effect of innovation attributes and taxpayer’s experience on the interest of the use of online tax filing system on individual taxpayers in Surabaya
Authors: Rahman Dody Setia , Mayasari Triana
Published: February 2017

So far, the reform in tax payment with its self-assessment system can provide a solu-tion required for better tax payment and bring public services to the community-oriented. However, the self-assessment system has shown a lot of weaknesses that make taxpayer services not optimal. The purpose of this study is to determine the factors that affect the interest of the use of online tax filing system on individual taxpayer in the Tax Office Pratama Surabaya City Karangpilang. The factors used as independent variables in this study are innovation attributes consisting of relative advantage, compatibility, complexity, trialability, observability and taxpayer’s experience. As many as 100 respondents comprising individual taxpayers are selected as respondents in the study. The results show that there is significant effect between innovation attributes consisting of relative advantage, compatibility, complexity, trialability, observability and taxpayer’s experience on the interest of the use of online tax filing system. And the researcher finds that most significant effect on the interest of the use of online tax filing system is compability.
Accountants‟ perceptions regarding to business and profession ethics (A study on the alumnus of STIE Perbanas Surabaya)
Authors: Setyorini Dewi , Uswati Dewi Nurul Hasanah
Published: February 2017

This study is aimed to determine the differences in the perception of the accounting student alumnus of STIE Perbanas Surabaya regarding the ethics of business and profession based on gender. The type of data used is primary data using question-naires. The sampling technique is using non-probability samples based on purposive sampling technique. The number of samples processed is 85 respondents from the accounting student alumnus of STIE Perbanas Surabaya. The statistical analysis tool is the Mann Whitney Test using SPSS version 16.0. The first hypothesis of this study can be concluded that there are differences in the perceptions of the account-ing student alumnus regarding the ethics of business and accountant profession based on gender. The second hypothesis indicates that there is no difference in the perception of the accounting student alumnus regarding the ethics of business and accountant profession based on gender, which has a significance level under 0.05 or 5 percent.
The effect of free cash flow and ownership structure on dividend payout ratio in manufacturing companies in Indonesia
Authors: Suhartono Afandi
Published: February 2017

Dividend policy is used to determine the amount of net profit after tax that will be distributed to shareholders and the amount of equity in the net income that will be used to finance the company's investment. Optimal dividend policy is a dividend policy that creates a balance between current dividends and growth in the future to maximize the company's stock price. The purpose of this study is to analyze the effect of Free Cash Flow (FCF) and Ownership Structure, consisting of Institutional Own-ership, Family Ownership and Foreign Ownership, on Dividend Payout Ratio (DPR) in manufacturing companies listed on the Indonesia Stock Exchange in 2011-2013. The research methodology used is descriptive analysis method and statistical analysis method. The data used is secondary data consisting of 173 research data used as the sample. Hypothesis testing is done by using multiple linear regression analysis. The results of regression analysis show that free cash flow, family ownership and foreign ownership have positive effect on dividend payout ratio, while institutional ownership does not have negative effect on dividend payout ratio.
The effect of comprehensive income disclosure on capital costs, earnings quality, and profitability
Authors: Negara Akbar Abdi , Almilia Luciana Spica Almilia
Published: February 2017

This study was induced by the change from SFAS 2009 to SFAS 2012. One of the changes contained in SFAS No. 1 states that comprehensive income statement is an additional component of other comprehensive income. The study aims to determine whether there are differences in the capital cost, earnings quality, and profitability be-tween companies that report comprehensive income statement and companies that do not report comprehensive income statement. The sample of the study consists of 120 manu-facturing companies listed on the Indonesian Stock Exchange (BEI) in 2012. It uses Statistical test that is the Mann Whitney test due to the data, which were not normally distributed. The results of the research indicate that the significance level of capital cost variable is 0.038, earnings quality variable is 0.192, and profitability variable is 0.029. Therefore, it can be concluded that there are differences in the level of capital cost and profitability between companies that report comprehensive statements and companies that do not report comprehensive income statement. On the contrary, there is no differ-ence in the level of earnings quality between companies that report comprehensive in-come statement and companies that do not report comprehensive income statement.
The influence of profitability ratio, market ratio, and solvency ratio on the share prices of companies listed on LQ 45 Index
Authors: Satryo Abhimada Gatuth , Rokhmania Nur Aini , Diptyana Pepie
Published: February 2017

This research aims to analyze the influence of profitability ratio, market ratio, and solvency ratio on the share price of companies listed on LQ 45 Index. The independent variables used in this research is Return on Assets (ROA), Return on Equity (ROE), Earning per Share (EPS), Price to Book Value (PBV), Debt to Equity Ratio (DER), and Debt to Assets Ratio (DAR), while the dependent variable used is share price. The samples of this study are companies listed on LQ 45 Index in Indonesia Stock Ex-change from 2010 to 2014. The samples are selected by using purposive sampling method and obtained 15 companies that fulfill the criteria specified. Data are processed using Multiple Regression Analysis and statistical test. The results of this study show that Return on Assets (ROA), Return on Equity (ROE), Debt to Equity Ratio (DER), and Debt to Assets Ratio (DAR) have no effect on share price, while Earning per Share (EPS) and Price to Book Value (PBV) have an effect on share price.
Knowledge, attitude and practices of male condom use among male employees, 50 years and older, at a diamond mining company in southern Namibia
Authors: Nakathingo Phillemon , Lerebo Wondwossen , Van Wyk Brian , Nuuyoma Vistolina
Published: February 2017

The HIV and AIDS pandemic has been characterised as the greatest health and development challenge ever to confront humanity, and is one of the great moral curses of our time. The pandemic has hit sub-Saharan Africa, and Namibia is one of the countries which are badly affected. In Namibia, the focus has been on the population aged 15 to 49 years. Hence, this study looks at older men in terms of it being a neglected population.A descriptive, cross-sectional survey utilizing a quantitative research approach was applied. Data were collected through face-to-face interviewing 105 randomly selected male employees aged 50 years and older. Data were captured in MS Excel and then imported into SPSS version 16.0. The level of statistical significance was set at 0.05.This study revealed that respondentsâ€™ knowledge about male condoms appeared to be moderate (52.4%). About 92.4% stated that correct and consistent use of male condoms prevents HIV transmission. A larger percentage (85.1%) of respondents disagreed that older men do not need to learn how to use a condom. A high percentage of respondents suggested that HIV-positive individuals should use condoms every time they have sexual intercourse.Men aged 50 years and older are not at risk of contracting HIV due to lack of knowledge of male condom use. Thus, to minimize the likelihood of HIV infection, targeted interventions including peer education programmes were suggested in order to strengthen the practice and attitudes.
Training research and development: Retrospective of a career in the Defense Department
Authors: Andrews Dee H.
Published: February 2017

I have had the privilege of spending a psychologist’s career serving the men and women who give service to our nation. Starting as an instructional psychologist, I’ve also been called upon to learn skills in the human factors and industrial/organizational psychology domains. I’ve been placed in numerous situations as a team member and leader where I learned how to work with multi-disciplinary teams of engineers, physicists, computer scientists, logisticians, and contract specialists. During 34 years as a Department of Defense (DoD) researcher and manager performing training research and five years working as a contractor since my retirement from the DoD, I can truly say it was a rare day . . . [Download PDF to read more]
Gry (dy)wersyfikacyjne, czyli o praktykowaniu poetyki w dydaktyce uniwersyteckiej
Authors: Grądziel-Wójcik Joanna
Published: February 2017

Artykuł omawia miejsce i zadania poetyki w uniwersyteckim kształceniu polonistycznym, która wprowadza studentów w podstawy teorii literatury oraz przygotowuje do praktykowania sztuki interpretacji. Szczególną uwagę autorka poświęca roli wersyfikacji w edukacji filologicznej, podkreślając jej strukturalistyczne tradycje oraz dążenie do semantyzacji i antropologizacji wersologicznych chwytów. Dzięki badaniom form wierszowych możliwe jest pożądane zbliżenie teorii do literatury, które pociąga za sobą sfunkcjonalizowanie wyborów wersyfikacyjnych w konkretnym, historycznie i społecznie określonym kontekście, tym samym włączając wersologię w przestrzeń współczesnej refleksji humanistycznej. Konieczne jest także dowartościowanie tej problematyki w kształceniu akademickim i jej dywersyfikacja poprzez przywoływanie również na przedmiotach historycznoliterackich.
Kompetencje informatyczne studentów filologii polskiej w latach 2010-2016
Authors: Wobalis Mirosław
Published: February 2017

W artykule podjęty zostaje temat kompetencji informatycznych studentów Filologii Polskiej w kontekście dynamicznego rozwoju technologii i tworzenia się społeczeństwa informacyjnego. Zaprezentowane zostały wyniki badań przeprowadzonych w latach 2010-2016 grupie 677 studentów przedmiotu „Edukacja naukowo-informatyczna” prowadzonego na Wydziale Filologii Polskiej i Klasycznej Uniwersytetu im. Adama Mickiewicza w Poznaniu. Wyniki badań prezentują profil studenta, który posiada istotne braki zarówno w posiadanej i uzyskanej w poprzednich etapach edukacji, wiedzy dotyczącej technologii informatycznych, komunikacji i Internetu, jak też niewystarczające umiejętności w zakresie pracy z dokumentami elektronicznymi, narzędziami biurowymi i internetowymi.
Badania, dydaktyka, rynek pracy – koncepcja studiów dwuprzedmiotowych
Authors: Skibski Krzysztof
Published: February 2017

Artykuł dotyczy koncepcji kształcenia polonistycznego uwzględniającego zarówno tradycyjne konteksty badawcze we współczesnej filologicznej praktyce naukowej, jak i sytuację na współczesnym rynku pracy. Polega ona na łączeniu dwu dyscyplin humanistycznych w jednym programie kształcenia i realizowaniu procesu dydaktycznego przez dwie jednostki naukowo-dydaktyczne (jedna z nich jest administratorem kierunku). Ważnym efektem takiej metody jest dwuprzedmiotowość jako walor kompetencyjny absolwenta, a także dobra orientacja w dwu tradycjach metodologicznych i swoistości dyscyplin wzajemnie na siebie oddziałujących. Eksponowanie dobranych w ten sposób kontekstów przyczynia się niewątpliwie do uatrakcyjnienia studiów, jak również powoduje, że absolwent – zwłaszcza nauczyciel – lepiej adaptuje się do zmiennych warunków pracy.Poznańska polonistyka uruchomiła w ostatnim czasie cztery takie kierunki (w połączeniu z historią, etyką, filologią klasyczną i filologią germańską), a doświadczenia zebrane podczas pracy nad programami, jak również podczas pracy z pierwszymi rocznikami studentów, dały podstawy do niniejszych analiz i wniosków (a także pytań).
Charlie i fabryka czekolady Roalda Dahla jako szkolna lektura. Rozumienie – doświadczenie – metafora – emocje
Authors: Michułka Dorota
Published: February 2017

Dominantą artystyczną utworu Roalda Dahla Charlie i fabryka czekolady (przywołanego jako szkolna lektura) i punktem wyjścia dla rozważań podjętych w tekście staje się przyciągająca czytelnika i oddziałująca na rozumienie tekstu, konstruowanie sensów i emocje, wyrazistość i plastyczność literackich obrazów (narracja wizualna i efekty wizualne) oraz polisensoryczność narracji Dahla. W opracowaniu zasobów empirycznych (części praktycznej) artykułu korzystałam z komentarzy do materiałów lekcyjnych (prac uczniów) szkoły podstawowej. Przeanalizowany materiał pozwala na sformułowanie następującego wniosku: wizualizacja efektów i afektów oraz metaforyzacja obrazów wzmacnianych doświadczeniem rzeczywistym może wpływać na emocjonalne zaangażowanie czytelnika/ucznia, wywierać wpływ na konstruowanie przez niego nowych znaczeń i sensów utworu oraz wzmacnia siłę interakcji, jaka zachodzi między słowem, obrazem i emocjami, co przekłada się w tym przypadku na wspomaganie rozumienia, kształtowanie wyobraźni i formułowanie etycznej refleksji nad światem.
Kształcenie humanistyczne w nowej rzeczywistości społeczno-medialnej
Authors: Winiecka Elżbieta
Published: February 2017

Artykuł prezentuje perspektywy kształcenia współczesnych polonistów. Autorka na przykładzie programu dwóch specjalizacji: komunikacji medialnej i kultury mediów cyfrowych, realizowanych w Instytucie Filologii Polskiej UAM, omawia wybrane wyzwania współczesnej polonistycznej edukacji akademickiej. Wskazuje na potrzebę poszerzenia kompetencji zawodowych studentów filologii polskiej o umiejętności z zakresu innych dyscyplin humanistycznych i nowych technologii. Odwołuje się w ten sposób do idei humanistyki cyfrowej.
Real‐time imaging of sodium glucose transporter (SGLT1) trafficking and activity in single cells
Authors: Ghezzi Chiara , Calmettes Guillaume , Morand Pauline , Ribalet Bernard , John Scott
Published: February 2017

The processes controlling targeting of glucose transporters to apical and basolateral membranes of polarized cells are complex and not‐well understood. We have engineered SGLT1 and GLUT4 constructs linked to fluorescent proteins to highlight the differences in transporter expression and trafficking, in real time, in different cell types. Activity was assessed in parallel using a FRET glucose sensor. In COS cells and HEK cells, SGLT1 was distributed between the plasma membrane and intracellular compartments, but there was little expression in CHO cells. Trafficking was investigated using the lysosome inhibitors NH4Cl (10 mmol/L) and chloroquine (150 μmol/L) and the proteasome inhibitors MG‐262 (1 μmol/L) and lactacystin (5 μmol/L). Lysosome inhibitors caused SGLT1 accumulation into intracellular bodies, whereas proteasome inhibitors induced SGLT1 accumulation in the plasma membrane, even in CHO cells. Our data suggest that a fraction of SGLT1 is rapidly degraded by lysosomes and never reached the plasma membrane; another fraction reaches the membrane and is subsequently degraded by lysosomes following internalization. The latter process is regulated by the ubiquitin/proteasome pathway, acting at a late stage of the lysosomal pathway. Using the cholesterol inhibitor MβCD (3 mmol/L), a dominant negative dynamin (K44A) and caveolin, we showed that SGLT1 internalization is lipid raft‐mediated, but caveolin‐independent. In contrast, GLUT4 internalization is dynamin‐dependent, but cholesterol‐independent. The physiological relevance of these data is discussed in terms of differential membrane compartmentalization of the transporters and expression under stress conditions.