bluuebunny/crossref_metadata_2025 huggingface dataset:
RINGS OF TETER TYPE
Authors: GASANOVA OLEKSANDRA , HERZOG JÜRGEN , HIBI TAKAYUKI , MORADI SOMAYEH
Published: June 2022

Let R be a Cohen–Macaulay local K-algebra or a standard graded K-algebra over a field K with a canonical module
$\omega _R$
. The trace of
$\omega _R$
is the ideal
$\operatorname {tr}(\omega _R)$
of R which is the sum of those ideals
$\varphi (\omega _R)$
with
${\varphi \in \operatorname {Hom}_R(\omega _R,R)}$
. The smallest number s for which there exist
$\varphi _1, \ldots , \varphi _s \in \operatorname {Hom}_R(\omega _R,R)$
with
$\operatorname {tr}(\omega _R)=\varphi _1(\omega _R) + \cdots + \varphi _s(\omega _R)$
is called the Teter number of R. We say that R is of Teter type if
$s = 1$
. It is shown that R is not of Teter type if R is generically Gorenstein. In the present paper, we focus especially on zero-dimensional graded and monomial K-algebras and present various classes of such algebras which are of Teter type.
Soviet National Autonomy in the 1920s: The Dilemmas of Ukraine’s Jewish Population
Authors: Raspe Jonathan
Published: June 2022

This article examines the Soviet system of territorial autonomy by studying its impact on the Jewish population of Soviet Ukraine in the 1920s. While the new Soviet state created national republics, districts, and village councils for its non-Russian nationalities, Ukraine’s Jewish population was faced with a dilemma: Ukrainian Jews lived predominantly in cities, but urban space could not be claimed for Jewish territorial autonomy because the Soviet government hoped that peasant immigration would produce a Ukrainian working class. Without an autonomous status, many Jews felt threatened by the increasing influx of Ukrainians and the spread of Ukrainian-language institutions. Offered as a consolation prize, the Soviet Yiddishization initiative failed to cater to the needs of many Jews who preferred the Russian language as a means for social mobility. Attempts to resettle urban Jews in compact agricultural colonies suitable for territorial autonomy never reached the necessary scale. In conclusion, this article argues that the incompatibility of Soviet territorial autonomy with Ukrainian Jewish needs anticipated the Soviet state’s inability to accommodate the increasingly urban, heterogeneous, transnational, multilingual, and mobile society that emerged in the postwar Soviet Union.
Resolving the fine structure in the energy landscapes of repeat proteins
Authors: Sanches Murilo N. , Parra R. Gonzalo , Viegas Rafael G. , Oliveira Antonio B. , Wolynes Peter G. , Ferreiro Diego U. , Leite Vitor B.P.
Published: June 2022

Ankyrin (ANK) repeat proteins are coded by tandem occurrences of patterns with around 33 amino acids. They often mediate protein–protein interactions in a diversity of biological systems. These proteins have an elongated non-globular shape and often display complex folding mechanisms. This work investigates the energy landscape of representative proteins of this class made up of 3, 4 and 6 ANK repeats using the energy-landscape visualisation method (ELViM). By combining biased and unbiased coarse-grained molecular dynamics AWSEM simulations that sample conformations along the folding trajectories with the ELViM structure-based phase space, one finds a three-dimensional representation of the globally funnelled energy surface. In this representation, it is possible to delineate distinct folding pathways. We show that ELViMs can project, in a natural way, the intricacies of the highly dimensional energy landscapes encoded by the highly symmetric ankyrin repeat proteins into useful low-dimensional representations. These projections can discriminate between multiplicities of specific parallel folding mechanisms that otherwise can be hidden in oversimplified depictions.
The relationship between dietary selenium intake and telomere length among diabetes
Authors: Gong Huping , Yu Qian , Guo Dawei , Wang Yuge , Duan Lanzhi , Huang Wenxuan , Zhou Jianghua , Wang Jiang , Huang Pan
Published: June 2022

Se is an indispensable trace element for the human body, and telomere length is considered a marker of biological ageing. Previous studies have shown that dietary Se intake is associated with telomere length. However, the relationship between Se intake and telomere length in patients with diabetes has not been well studied. Therefore, this study aimed to investigate the relationship between dietary Se intake and telomere length in patients with diabetes. We extracted 878 participants with diabetes from the National Health and Nutrition Examination Survey database for 1990–2002. Dietary Se intake was assessed using the 24 h dietary recall method, and telomere length was measured using quantitative PCR. Generalised linear models were constructed to assess the relationship between dietary Se intake and telomere length. After controlling for the confounders, 1 μg increase in dietary Se intake in female patients with diabetes, and telomere length increased by 1·84 base pairs (β = 1·84 (95 % CI: 0·15, 3·53)), there was a line relationship between dietary Se intake and telomere length in female patients with diabetes and telomere length increased with increasing dietary Se intake within the range of 0–250 μg. The study demonstrates that dietary Se intake is significantly associated with telomere length only in the female population with diabetes in the USA. However, further prospective studies are required to confirm this finding.
An Empirical Assessment of Empirical Corporate Finance
Authors: Coles Jeffrey L. , Li Zhichuan F.
Published: June 2022

We empirically evaluate 20 prominent contributions across a broad range of areas in the empirical corporate finance literature. We assemble the necessary data and apply a single, simple econometric method, the connected-groups approach of Abowd et al. to appraise the extent to which prevailing empirical specifications explain variation of the dependent variable, differ in composition of fit arising from various classes of independent variables, and exhibit resistance to omitted variable bias and other endogeneity problems. We assess empirical performance across a wide spectrum of areas in corporate finance and indicate varying research opportunities for empiricists and theorists.
Increased incident rates of antidepressant use during the COVID-19 pandemic: interrupted time-series analysis of a nationally representative sample
Authors: Frangou Sophia , Travis-Lumer Yael , Kodesh Arad , Goldberg Yair , New Faye , Reichenberg Abraham , Levine Stephen Z.
Published: June 2022

Background

The COVID-19 pandemic has been associated with increased levels of depression and anxiety with implications for the use of antidepressant medications.

Methods

The incident rate of antidepressant fills before and during the COVID-19 pandemic were compared using interrupted time-series analysis followed by comprehensive sensitivity analyses on data derived from electronic medical records from a large health management organization providing nationwide services to 14% of the Israeli population. The dataset covered the period from 1 January 2013 to 1 February 2021, with 1 March 2020 onwards defined as the period of the COVID-19 pandemic. Forecasting analysis was implemented to test the effect of the vaccine roll-out and easing of social restrictions on antidepressant use.

Results

The sample consisted of 852 233 persons with a total antidepressant incident fill count of 139 535.4 (total cumulative rate per 100 000 = 16 372.91, 95% CI 16 287.19–16 459.01). We calculated the proportion of antidepressant prescription fills for the COVID-19 period, and the counterfactual proportion for the same period, assuming COVID-19 had not occurred. The difference in these proportions was significant [Cohen's h = 10−3 (0.16), 95% CI 10−3 ( − 0.71 to 1.03)]. The pandemic was associated with a significant increase in the slope of the incident rate of antidepressant fills (slope change = 0.01, 95% CI 0.00–0.03; p = 0.04) and a monthly increase of 2% compared to the counterfactual (the estimated rate assuming no pandemic occurred). The increased rate was more pronounced in women, and was not modified by lockdown on/off periods, socioeconomic or SARS-CoV-2 status. The rate of observed antidepressant fills was similar to that forecasted under the assumption of ongoing COVID-19 distress.

Conclusion

These findings underscore the toll of the pandemic on mental health and inform mental health policy and service delivery during and after implementing COVID-19 attenuation strategies.
Modes of relating to the new ICTs among older internet users: a qualitative approach
Authors: Coelho Ana Rita
Published: June 2022

Older people have increasingly been using the new information and communication technologies (ICTs), namely the internet. Seeking to contribute with substantive information on their digital inclusion, this paper focuses on the adoption and use of ICTs by older adults, highlighting their experiences and considering their plurality. Taking a qualitative approach, the core goal of the empirical research underlying this paper was to understand what mechanisms and modalities configure the relationship of older internet users with the new ICTs. With that objective in mind, interviews were conducted with 20 internet users over the age of 60. Those interviews, which included a biographical element, were subjected to multi-categorical analysis. Results suggest a typology of modes of relating to the new ICTs among older internet users that reflects different trajectories, practices, skills, significances and impacts. The analysis shows how life trajectories and differentiated uses are reflected in equally differentiated impacts for older adults, contributing to their quality of life in different ways and to different degrees. Digital skills play a fundamental role in enhancing or limiting those effects. The results of this research help break down the stereotypes associated with the older generations and may have relevant implications for the design of digital inclusion policies and initiatives.
A place outside the pandemic? An ethnographic study of live music events at St Gallen's cultural venue Palace during the COVID-19 crisis
Authors: Gligorijevic Jelena
Published: June 2022

The multiple impacts of COVID-19 on the music-culture industry have been duly discussed in a variety of public discourses, academic and otherwise. However, there is still a dearth of studies that investigate alternative face-to-face practices of live music performance and organisation during the pandemic's significant constraints on social behaviour. The present work aims to fill this gap by offering an anthropological angle on live music practices during COVID-19. It specifically draws on fieldwork that I could carry out in the autumn of 2020 at a live music venue – ‘Palace’ in the Swiss city of St Gallen – owing to a ‘liberal’ handling of the COVID-19 crisis by the St Gallen authorities. This article documents accordingly the challenges and adjustments that Palace had to undergo during pandemic times from the perspectives of producers, musicians and audiences alike. The primary focus here is on exploring changes in the venue's management, programming, audience composition and especially the musical-aesthetic experience of the venue's pandemic-compliant gigs. Finally, the article draws on the musings of my interlocutors as to whether Palace was in their experience a place outside the pandemic, to tackle the larger question of how COVID-19 has affected people's perceptions of live gigs and urban nightlife more generally.
Equivalency of multi-state survival signatures of multi-state systems of different sizes and its use in the comparison of systems
Authors: Yi He , Balakrishnan Narayanaswamy , Li Xiang
Published: June 2022

In this paper, the multi-state survival signature is first redefined for multi-state coherent or mixed systems with independent and identically distributed (i.i.d.) multi-state components. With the assumption of independence of component lifetimes at different state levels, transformation formulas of multi-state survival signatures of different sizes are established through the use of equivalent systems and a generalized triangle rule for order statistics from several independent and non-identical distributions. The results obtained facilitate stochastic comparisons of multi-state coherent or mixed systems with different numbers of i.i.d. multi-state components. Specific examples are finally presented to illustrate the transformation formulas established here, and also their use in comparing systems of different sizes.
MILTON FRIEDMAN’S EMPIRICAL APPROACH TO ECONOMICS: SEARCHING FOR SCIENTIFIC AUTHORITY WHILE SHAPING THE UNIVERSITY OF CHICAGO ECONOMICS DEPARTMENT
Authors: Orozco Espinel Camila
Published: June 2022

Milton Friedman is usually presented as an economist characterized by his empirical approach to economics. His binary classification of economics intopositive meansandnormative endsrelies on the empirical content of predictions. Throughout his career, he used extensive, data-based statistical techniques. While important scholarly attention has been devoted to Friedman’s academic and political trajectories, his methodological prescriptions, and the development of economics at the University of Chicago, we know much less about the interplay of these elements. This paper proposes an intertwined reading of them. My aim is threefold. First, to understand Friedman’s work and methodological choices, I relate his empirical approach to his early training in statistics. Second, I articulate Friedman’s understanding of economics as an empirical policy science in the process of building the image of economists as neutral advisers in the policy-making process. Third, I claim that Friedman’s empirical methodological framework, developed while he was in the Economics Department of the University of Chicago, established the guidelines for an institutional long-term project that shaped it.
An Automated Scanning Transmission Electron Microscope Guided by Sparse Data Analytics
Authors: Olszta Matthew , Hopkins Derek , Fiedler Kevin R , Oostrom Marjolein , Akers Sarah , Spurgeon Steven R
Published: June 2022

Artificial intelligence (AI) promises to reshape scientific inquiry and enable breakthrough discoveries in areas such as energy storage, quantum computing, and biomedicine. Scanning transmission electron microscopy (STEM), a cornerstone of the study of chemical and materials systems, stands to benefit greatly from AI-driven automation. However, present barriers to low-level instrument control, as well as generalizable and interpretable feature detection, make truly automated microscopy impractical. Here, we discuss the design of a closed-loop instrument control platform guided by emerging sparse data analytics. We hypothesize that a centralized controller, informed by machine learning combining limited a priori knowledge and task-based discrimination, could drive on-the-fly experimental decision-making. This platform may unlock practical, automated analysis of a variety of material features, enabling new high-throughput and statistical studies.
Novel Identification and Microscopy of the Intestinal Bulb of Molly Fish (Poecilia sphenops) with a Focus on Its Role in Immunity
Authors: Mokhtar Doaa M , Hussein Marwa M , Sayed Ramy K A
Published: June 2022

The intestinal bulb is a simple dilatation in the anterior part of the intestine of agastric fish. This study was conducted on 18 adult specimens of molly fish (Poecilia sphenops) and demonstrated the presence of an intestinal bulb. The intestinal epithelium was composed of enterocytes covered with microvilli, many mucous goblet cells, and enteroendocrine cells. Numerous intraepithelial lymphocytes, neutrophils, plasma cells, dendritic cells, stem cells, rodlet cells, and macrophages were identified in the epithelial layer. Interestingly, this study recorded the process of autophagy and formation of autophagosomes, multivesicular bodies, and dense bodies. The intestinal epithelium extended into the intestinal gland that consisted of simple columnar epithelium, mucous cells, stem cells, enteroendocrine cells, and basal cells. These glands opened to the lumen of the bulb and were surrounded by a network of telocytes. Moreover, immunohistochemistry revealed that the intestinal epithelium expressed APG5, myostatin, TGF-β, IL-1β, NF-κB, Nrf2, and SOX9. Leukocytes in the lamina propria-submucosa expressed APG5. The inflammatory cells in the connective tissue showed strong immunoreactivity to myostatin and TGF-β. The smooth muscular layer also expressed myostatin. Both IL-1β and NF-κB showed immunoreactivity in macrophages in the lamina propria-submucosa. Stem cells expressed Sox-9 and telocytes expressed NF-κB and SOX9; while astrocytes in the tunica muscularis expressed GFAP. The high frequency of immune cells in the intestinal bulb suggested an immune role of this organ. This is the first study demonstrating the absence of the stomach and its replacement with an intestinal bulb in molly fish, and consequently, this species could be reclassified as agastric fish according to this study.
Optimizing weed control using dicamba and glufosinate in eligible crop systems
Authors: Priess Grant L. , Popp Michael P. , Norsworthy Jason K. , Mauromoustakos Andy , Roberts Trenton L. , Butts Thomas R.
Published: June 2022

A field experiment was conducted in 2019 and 2020 that included six site-years and four locations in Arkansas to determine the optimal sequence and timing of dicamba and glufosinate applications when applied alone, sequentially, or in combination to control Palmer amaranth by size: labeled (<10 cm height) and non-labeled (13 to 25 cm height). Single applications of dicamba, glufosinate, and dicamba plus glufosinate (not labeled) resulted in less than 80% Palmer amaranth control, regardless of weed size. The mixture of dicamba plus glufosinate was antagonistic for Palmer amaranth control and percent mortality. Sequential applications, averaged over all time intervals and herbicides, improved the percentage of Palmer amaranth control 11 to 17 percentage points over a single application, regardless of weed size at application 28 d after final application (DAFA). Palmer amaranth control with glufosinate followed by (fb) glufosinate and dicamba fb dicamba, pending weed size, were optimized at intervals of 7 d, and 14 to 21 d, respectively. Because single site of action (SOA) postemergence herbicide systems increase the likelihood of the development of resistant biotypes and are not a best management practice (BMP) in that regard; sequential applications involving both dicamba and glufosinate were more effective. Furthermore, the sequence of application mattered with a preference for applying dicamba first. Dicamba fb glufosinate at a 14-d interval was profit-maximizing and the only herbicide treatment that resulted in 100% weed control when size was <10 cm. For larger weed sizes, economic analysis revealed that dicamba fb dicamba performed better than dicamba fb glufosinate when no penalty was assigned for using a single SOA. This resulted in greater yield loss risk and soil weed seed bank in comparison to timelier weed control with the smaller weed size. Hence, timely weed control and two SOAs to control Palmer amaranth are recommended as BMPs that reduce producer risk.
Variability in the Concentration of Lithium in the Indo‐Pacific Ocean
Authors: Steiner Zvi , Landing William M. , Bohlin Madeleine S. , Greaves Mervyn , Prakash Satya , Vinayachandran P. N. , Achterberg Eric P.
Published: June 2022

Lithium has limited biological activity and can readily replace aluminium, magnesium and iron ions in aluminosilicates, making it a proxy for the inorganic silicate cycle and its potential link to the carbon cycle. Data from the North Pacific Ocean, tropical Indian Ocean, Southern Ocean and Red Sea suggest that salinity normalized dissolved lithium concentrations vary by up to 2%–3% in the Indo‐Pacific Ocean. The highest lithium concentrations were measured in surface waters of remote North Pacific and Indian Ocean stations that receive relatively high fluxes of dust. The lowest dissolved lithium concentrations were measured just below the surface mixed layer of the stations with highest surface water concentrations, consistent with removal into freshly forming aluminium rich phases and manganese oxides. In the North Pacific, water from depths >2,000 m is slightly depleted in lithium compared to the initial composition of Antarctic Bottom Water, likely due to uptake of lithium by authigenically forming aluminosilicates. The results of this study suggest that the residence time of lithium in the ocean may be significantly shorter than calculated from riverine and hydrothermal fluxes.
The Dominant Role of the Water Column in Nitrogen Removal and N2O Emissions in Large Rivers
Authors: Wang Junfeng , Xia Xinghui , Liu Shaoda , Zhang Sibo , Zhang Ling , Jiang Chenrun , Zhang Zhenrui , Xin Yuan , Chen Xin , Huang Jing , Bao Jiaao , McDowell William H. , Michalski Greg , Yang Zhifeng , Xia Jun
Published: June 2022

Rivers are important sites for nitrogen (N) cycling processes. N removal is thought to occur predominantly in the benthic zone and the role of the water column is frequently neglected. Here, we find that the water‐air and sediment‐water fluxes of N2 and N2O decreased, while the water column production increased with stream order through 4‐year observations across six river networks in China. The water column contribution increased with stream order and accounted for more than 50% in rivers above fifth order. The increase in the contact area of suspended sediment (SPS)‐water caused by higher SPS concentrations and river depths resulted in the shift as river size increased. N removal and N2O emissions would be underestimated approximately by 50% if neglecting water column processes for the six river networks. This study highlights the necessity and provides a pathway to incorporate water column processes into models to balance the global N budget.
Can Column Formaldehyde Observations Inform Air Quality Monitoring Strategies for Ozone and Related Photochemical Oxidants?
Authors: Travis K. R. , Judd L. M. , Crawford J. H. , Chen Gao , Szykman James , Whitehill Andrew , Valin Lukas C. , Spinei Elena , Janz Scott , Nowlan Caroline R. , Kwon Hyeong‐Ahn , Fried Alan , Walega James
Published: June 2022

Formaldehyde column density (ΩHCHO) showed a potentially useful correlation with surface ozone during the LISTOS campaign on Long Island Sound and the KORUS‐AQ campaign in Seoul, South Korea. This builds on previous work that identified this relationship from in situ aircraft observations with similar findings for ground‐based and airborne remote sensing of ΩHCHO. In the Long Island Sound region, ΩHCHO and surface ozone exhibited strong temporal (r2 = 0.66) and spatial (r2 = 0.73) correlation. The temporal variability in ΩHCHO (∼1 Dobson units [DU]) was larger than the range in the spatial average (∼0.1 DU). The spatial average is most useful for informing ozone monitoring strategies, demonstrating the challenge in using ΩHCHO satellite data sets for this purpose. In Seoul, high levels of NO2 resulted in Ox better correlating with ΩHCHO than surface ozone due to titration effects. The ΩHCHO–Ox relationship may therefore reflect the sum of surface ozone and related photochemical oxidants, relevant to air quality standards set to regulate this quantity such as the U.S. EPA National Ambient Air Quality Standard (NAAQS). The relationship of ΩHCHO to Ox shifted in Seoul during the campaign demonstrating the need to evaluate this relationship over longer time periods. With sufficient precision in future satellite retrievals, ΩHCHO observations could be useful for evaluating the adequacy of surface air quality monitoring strategies.
Rare-earth based materials: an effective toolbox for brain imaging, therapy, monitoring and neuromodulation
Authors: Wei Zheng , Liu Yawei , Li Bo , Li Jingjing , Lu Shuang , Xing Xiwen , Liu Kai , Wang Fan , Zhang Hongjie
Published: June 2022

Brain diseases, including tumors and neurodegenerative disorders, are among the most serious health problems. Non-invasively high-resolution imaging methods are required to gain anatomical structures and information of the brain. In addition, efficient diagnosis technology is also needed to treat brain disease. Rare-earth based materials possess unique optical properties, superior magnetism, and high X-ray absorption abilities, enabling high-resolution imaging of the brain through magnetic resonance imaging, computed tomography imaging, and fluorescence imaging technologies. In addition, rare-earth based materials can be used to detect, treat, and regulate of brain diseases through fine modulation of their structures and functions. Importantly, rare-earth based materials coupled with biomolecules such as antibodies, peptides, and drugs can overcome the blood-brain barrier and be used for targeted treatment. Herein, this review highlights the rational design and application of rare-earth based materials in brain imaging, therapy, monitoring, and neuromodulation. Furthermore, the development prospect of rare-earth based materials is briefly introduced.
Investigation progresses of rare earth complexes as emitters or sensitizers in organic light-emitting diodes
Authors: Li Shuaibing , Zhou Liang , Zhang Hongjie
Published: June 2022

Due to unique photo-physical characteristics, rare earth (RE) complexes play important roles in many fields, for example, telecommunications, life science, and organic light-emitting diodes (OLEDs). Especially, thanks to narrow emission bandwidth and 100% theoretical internal quantum efficiency (IQE), the study of RE complexes in the electroluminescence field has been a hot research topic in recent 30 years. As a leading technology in solid-state light source fields, OLEDs have attracted great interest from academic researchers and commercial endeavors. In the last decades, OLED-based products have trickled into the commercial market and developed quickly into portable display devices. Here, we briefly introduce the luminescent characteristics and electroluminescent (EL) study of RE complexes in material synthesis and device design. Moreover, we emphatically reveal the innovative application of RE complexes as sensitizers in OLEDs. Through experimental validation, the application of RE complexes as sensitizers can realize the complementary advantages of RE complexes and transition metal complexes, leading to significantly improved performances of OLEDs. The application of RE complexes as sensitizers provides a new strategy for designing and developing novel high performances OLEDs.
Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs
Authors: Mahmoud Asmaa A. , Aboelghar Hesham M. , Abdelmageed Sabry Moawad , Abdallah Heba M. , Garib Mohamed I. , Abd El Hady Nahla M. S.
Published: June 2022

Background

Epilepsy is a neurological disease that requires long-term antiepileptic drugs (AEDs). The old generation of AEDs may affect serum homocysteine and asymmetric dimethylarginine (ADMA) and disturb lipid levels. The aim of the study was to evaluate serum ADMA, homocysteine, lipid profile, and carotid intima-media thickness (CIMT) in epileptic children.

Methods

This study was implemented on 159 epileptic children who were subdivided into 3 subgroups, with 53 receiving sodium valproate, 53 receiving levetiracetam, and 53 receiving polytherapy, for over 6 months and 53 healthy children.

Results

Low-density lipoprotein, triglycerides, and cholesterol levels were increased in epileptic children (p < 0.001), which were higher in those receiving multidrug followed by a valproate receiver. While high-density lipoprotein was lower in those receiving multidrug more than those receiving valproate. ADMA and homocysteine levels increased in epileptic patients than in controls (p < 0.001). Higher ADMA was also observed in the multidrug receiver (5.78 ± 0.62), followed by the levetiracetam group (5.56 ± 0.61). Homocysteine levels were significantly higher in multidrug and valproate-treated children than those treated with levetiracetam. CIMT was significantly higher in multidrug and valproate-treated patients (p < 0.001).

Conclusions

Long-term use of AEDs, especially old-generation polytherapy, can elevate lipid profiles, homocysteine, ADMA levels, and carotid intima-media thickness compared to the minimal effect of new AEDs.

Impact

The long-term use of antiepileptic drugs, especially old-generation polytherapy, can increase lipid profiles, homocysteine levels, ADMA, and carotid intima thickness compared to the minimal effect of new antiepileptic generation.

A routine follow-up of these markers and a lifestyle modification are recommended to avoid cerebrovascular events as much as possible.
Chronic clomipramine treatment increases hippocampal volume in rats exposed to chronic unpredictable mild stress
Authors: Zhang Shanshan , Hu Juntao , Liu Guixue , Wu Haoran , Li Meihui , Shi Chenye , Liu Qiong , Li Wensheng
Published: June 2022

It is well known that neuroinflammation is closely related to the pathophysiology of depression. Due to individual differences in clinical research, the reduction of hippocampal volume in patients with depression is still controversial. In this experiment, we studied a typical kind of tricyclic antidepressant, clomipramine. We designed a series of experiments to find its role in depressive-like behavior, hippocampal neuroinflammation as well as hippocampal volume changes induced by chronic unpredictable mild stress (CMS). Rats exhibited defective behavior and hippocampal neuroinflammation after 12 weeks of CMS, which included elevated expression of cleaved interleukin-1β (IL-1β) and NLRP3 inflammasome together with the activation of microglia. Rats exposed to CMS showed weakened behavioral defects, reduced expression of IL-18, IL-6, and IL-1β along with reversed activation of microglia after clomipramine treatment. This indicates that the antidepressant effect of clomipramine may be related to the reduced expression of NLRP3 inflammasome and cleaved IL-1β. Moreover, we found an increased hippocampal volume in rats exposed to CMS after clomipramine treatment while CMS failed to affect hippocampal volume. All these results indicate that the NLRP3 inflammasome of microglia in the hippocampus is related to the antidepressant effects of clomipramine and CMS-induced depressive-like behavior in rats.
The protective effects of systemic dexamethasone on sensory epithelial damage and hearing loss in targeted Cx26-null mice
Authors: Xu Kai , Chen Sen , Xie Le , Qiu Yue , Liu Xiao-zhou , Bai Xue , Jin Yuan , Wang Xiao-hui , Sun Yu
Published: June 2022

Mutations in the GJB2 gene (encoding Connexin26(Cx26)) are the most common cause of hereditary deafness, accounting for about a quarter of all cases. Sensory epithelial damage is considered to be one of the main causes of deafness caused by GJB2 gene mutation. Dexamethasone (DEX) is widely used in the treatment of a variety of inner ear diseases including sudden sensorineural hearing loss (SSNHL), noise-induced hearing loss (NIHL), and deafness caused by ototoxic drugs. Whether DEX has a direct therapeutic effect on hereditary deafness, especially GJB2-related deafness, remains unclear. In this study, we revealed that DEX can effectively prevent hair cell death caused by oxidative stress in cochlear explants. Additionally, two distinct Cx26-null mouse models were established to investigate whether systemic administration of DEX alleviate the cochlear sensory epithelial injury or deafness in these models. In a specific longitudinally Cx26-null model that does not cause deafness, systemic administration of DEX prevents the degeneration of outer hair cells (OHCs) induced by Cx26 knockout. Similarly, in a targeted-Deiter’s cells (DCs) Cx26-null mouse model that causes deafness, treatment with DEX can almost completely prevent OHCs loss and alleviates auditory threshold shifts at some frequencies. Additionally, we observed that DEX inhibited the recruitment of CD45-positive cells in the targeted-DCs Cx26-null mice. Taken together, our results suggest that the protective effect of dexamethasone on cochlear sensory epithelial damage and partially rescue auditory function may be related to the regulation of inner ear immune response in Cx26 deficiency mouse models.
Stable choice coding in rat frontal orienting fields across model-predicted changes of mind
Authors: Boyd-Meredith J. Tyler , Piet Alex T. , Dennis Emily Jane , El Hady Ahmed , Brody Carlos D.
Published: June 2022

During decision making in a changing environment, evidence that may guide the decision accumulates until the point of action. In the rat, provisional choice is thought to be represented in frontal orienting fields (FOF), but this has only been tested in static environments where provisional and final decisions are not easily dissociated. Here, we characterize the representation of accumulated evidence in the FOF of rats performing a recently developed dynamic evidence accumulation task, which induces changes in the provisional decision, referred to as “changes of mind”. We find that FOF encodes evidence throughout decision formation with a temporal gain modulation that rises until the period when the animal may need to act. Furthermore, reversals in FOF firing rates can be accounted for by changes of mind predicted using a model of the decision process fit only to behavioral data. Our results suggest that the FOF represents provisional decisions even in dynamic, uncertain environments, allowing for rapid motor execution when it is time to act.
Dendritic crystallization in hydrous basaltic magmas controls magma mobility within the Earth’s crust
Authors: Arzilli Fabio , Polacci Margherita , La Spina Giuseppe , Le Gall Nolwenn , Llewellin Edward W. , Brooker Richard A. , Torres-Orozco Rafael , Di Genova Danilo , Neave David A. , Hartley Margaret E. , Mader Heidy M. , Giordano Daniele , Atwood Robert , Lee Peter D. , Heidelbach Florian , Burton Mike R.
Published: June 2022

The majority of basaltic magmas stall in the Earth’s crust as a result of the rheological evolution caused by crystallization during transport. However, the relationships between crystallinity, rheology and eruptibility remain uncertain because it is difficult to observe dynamic magma crystallization in real time. Here, we present in-situ 4D data for crystal growth kinetics and the textural evolution of pyroxene during crystallization of trachybasaltic magmas in high-temperature experiments under water-saturated conditions at crustal pressures. We observe dendritic growth of pyroxene on initially euhedral cores, and a surprisingly rapid increase in crystal fraction and aspect ratio at undercooling ≥30 °C. Rapid dendritic crystallization favours a rheological transition from Newtonian to non-Newtonian behaviour within minutes. We use a numerical model to quantify the impact of rapid dendritic crystallization on basaltic dike propagation, and demonstrate its dramatic effect on magma mobility and eruptibility. Our results provide insights into the processes that control whether intrusions lead to eruption or not.
Epitaxial growth of inch-scale single-crystal transition metal dichalcogenides through the patching of unidirectionally orientated ribbons
Authors: Yang Pengfei , Wang Dashuai , Zhao Xiaoxu , Quan Wenzhi , Jiang Qi , Li Xuan , Tang Bin , Hu Jingyi , Zhu Lijie , Pan Shuangyuan , Shi Yuping , Huan Yahuan , Cui Fangfang , Qiao Shan , Chen Qing , Liu Zheng , Zou Xiaolong , Zhang Yanfeng
Published: June 2022

Two-dimensional (2D) semiconductors, especially transition metal dichalcogenides (TMDs), have been envisioned as promising candidates in extending Moore’s law. To achieve this, the controllable growth of wafer-scale TMDs single crystals or periodic single-crystal patterns are fundamental issues. Herein, we present a universal route for synthesizing arrays of unidirectionally orientated monolayer TMDs ribbons (e.g., MoS2, WS2, MoSe2, WSe2, MoSxSe2-x), by using the step edges of high-miller-index Au facets as templates. Density functional theory calculations regarding the growth kinetics of specific edges have been performed to reveal the morphological transition from triangular domains to patterned ribbons. More intriguingly, we find that, the uniformly aligned TMDs ribbons can merge into single-crystal films through a one-dimensional edge epitaxial growth mode. This work hereby puts forward an alternative pathway for the direct synthesis of inch-scale uniform monolayer TMDs single-crystals or patterned ribbons, which should promote their applications as channel materials in high-performance electronics or other fields.
Exploring the cellular landscape of circular RNAs using full-length single-cell RNA sequencing
Authors: Wu Wanying , Zhang Jinyang , Cao Xiaofei , Cai Zhengyi , Zhao Fangqing
Published: June 2022

Previous studies have demonstrated the highly specific expression of circular RNAs (circRNAs) in different tissues and organisms, but the cellular architecture of circRNA has never been fully characterized. Here, we present a collection of 171 full-length single-cell RNA-seq datasets to explore the cellular landscape of circRNAs in human and mouse tissues. Through large-scale integrative analysis, we identify a total of 139,643 human and 214,747 mouse circRNAs in these scRNA-seq libraries. We validate the detected circRNAs with the integration of 11 bulk RNA-seq based resources, where 216,602 high-confidence circRNAs are uniquely detected in the single-cell cohort. We reveal the cell-type-specific expression pattern of circRNAs in brain samples, developing embryos, and breast tumors. We identify the uniquely expressed circRNAs in different cell types and validate their performance in tumor-infiltrating immune cell composition deconvolution. This study expands our knowledge of circRNA expression to the single-cell level and provides a useful resource for exploring circRNAs at this unprecedented resolution.
Excess ribosomal protein production unbalances translation in a model of Fragile X Syndrome
Authors: Seo Sang S. , Louros Susana R. , Anstey Natasha , Gonzalez-Lozano Miguel A. , Harper Callista B. , Verity Nicholas C. , Dando Owen , Thomson Sophie R. , Darnell Jennifer C. , Kind Peter C. , Li Ka Wan , Osterweil Emily K.
Published: June 2022

Dysregulated protein synthesis is a core pathogenic mechanism in Fragile X Syndrome (FX). The mGluR Theory of FX predicts that pathological synaptic changes arise from the excessive translation of mRNAs downstream of mGlu1/5 activation. Here, we use a combination of CA1 pyramidal neuron-specific TRAP-seq and proteomics to identify the overtranslating mRNAs supporting exaggerated mGlu1/5 -induced long-term synaptic depression (mGluR-LTD) in the FX mouse model (Fmr1−/y). Our results identify a significant increase in the translation of ribosomal proteins (RPs) upon mGlu1/5 stimulation that coincides with a reduced translation of long mRNAs encoding synaptic proteins. These changes are mimicked and occluded in Fmr1−/y neurons. Inhibiting RP translation significantly impairs mGluR-LTD and prevents the length-dependent shift in the translating population. Together, these results suggest that pathological changes in FX result from a length-dependent alteration in the translating population that is supported by excessive RP translation.
N-Aminopyridinium reagents as traceless activating groups in the synthesis of N-Aryl aziridines
Authors: Tan Hao , Samanta Samya , Maity Asim , Roychowdhury Pritam , Powers David C.
Published: June 2022

N-functionalized aziridines, which are both useful intermediates and important synthetic targets, can be envisioned as arising from the addition of nitrenes (i.e., NR fragments) to olefinic substrates. The exceptional reactivity of most nitrenes, in particular with respect to unimolecular decomposition, prevents general application of nitrene-transfer to the synthesis ofN-functionalized aziridines. Here we demonstrateN-aryl aziridine synthesis via 1) olefin aziridination withN-aminopyridinium reagents to affordN-pyridinium aziridines followed by 2) Ni-catalyzed C–N cross-coupling of theN-pyridinium aziridines with aryl boronic acids. TheN-pyridinium aziridine intermediates also participate in ring-opening chemistry with a variety of nucleophiles to afford 1,2-aminofunctionalization products. Mechanistic investigations indicate aziridine cross-coupling proceeds via a noncanonical mechanism involving initial aziridine opening promoted by the bromide counterion of the Ni catalyst, C–N cross-coupling, and finally aziridine reclosure. Together, these results provide new opportunities to achieve selective incorporation of generic aryl nitrene equivalents in organic molecules.
Hydrological control of river and seawater lithium isotopes
Authors: Zhang Fei , Dellinger Mathieu , Hilton Robert G. , Yu Jimin , Allen Mark B. , Densmore Alexander L. , Sun Hui , Jin Zhangdong
Published: June 2022

Seawater lithium isotopes (δ7Li) record changes over Earth history, including a ∼9‰ increase during the Cenozoic interpreted as reflecting either a change in continental silicate weathering rate or weathering feedback strength, associated with tectonic uplift. However, mechanisms controlling the dissolved δ7Li remain debated. Here we report time-series δ7Li measurements from Tibetan and Pamir rivers, and combine them with published seasonal data, covering small (<102  km2) to large rivers (>106 km2). We find seasonal changes in δ7Li across all latitudes: dry seasons consistently have higher δ7Li than wet seasons, by −0.3‰ to 16.4‰ (mean 5.0 ± 2.5‰). A globally negative correlation between δ7Li and annual runoff reflects the hydrological intensity operating in catchments, regulating water residence time and δ7Li values. This hydrological control on δ7Li is consistent across climate events back to ~445 Ma. We propose that hydrological changes result in shifts in river δ7Li and urge reconsideration of its use to examine past weathering intensity and flux, opening a new window to reconstruct hydrological conditions.
QTL mapping for resistance against cereal cyst nematode (Heterodera avenae Woll.) in wheat (Triticum aestivum L.)
Authors: Pundir Saksham , Sharma Rajiv , Kumar Deepak , Singh Vikas Kumar , Chaturvedi Deepti , Kanwar Rambir Singh , Röder Marion S. , Börner Andreas , Ganal Martin W. , Gupta Pushpendra Kumar , Sharma Shailendra , Sharma Shiveta
Published: June 2022

The resistance to cereal cyst nematode (Heterodera avenae Woll.) in wheat (Triticum aestivum L.) was studied using 114 doubled haploid lines from a novel ITMI mapping population. These lines were screened for nematode infestation in a controlled environment for two years. QTL-mapping analyses were performed across two years (Y1 and Y2) as well as combining two years (CY) data. On the 114 lines that were screened, a total of 2,736 data points (genotype, batch or years, and replication combinations) were acquired. For QTL analysis, 12,093 markers (11,678 SNPs and 415 SSRs markers) were used, after filtering the genotypic data, for the QTL mapping. Composite interval mapping, using Haley-Knott regression (hk) method in R/QTL, was used for QTL analysis. In total, 19 QTLs were detected out of which 13 were novel and six were found to be colocalized or nearby to previously reported Cre genes, QTLs or MTAs for H. avenae or H. filipjevi. Nine QTLs were detected across all three groups (Y1, Y2 and CY) including a significant QTL "QCcn.ha-2D" on chromosome 2D that explains 23% of the variance. This QTL colocalized with a previously identified Cre3 locus. Novel QTL, QCcn.ha-2A, detected in the present study could be the possible unreported homeoloci to QCcn.ha-2D, QCcn.ha-2B.1 and QCcn.ha-2B.2. Six significant digenic epistatic interactions were also observed. In addition, 26 candidate genes were also identified including genes known for their involvement in PPNs (plant parasitic nematodes) resistance in different plant species. In-silico expression of putative candidate genes showed differential expression in roots during specific developmental stages. Results obtained in the present study are useful for wheat breeding to generate resistant genetic resources against H. avenae.
Mutation induced infection waves in diseases like COVID-19
Authors: Schwarzendahl Fabian Jan , Grauer Jens , Liebchen Benno , Löwen Hartmut
Published: June 2022

After more than 6 million deaths worldwide, the ongoing vaccination to conquer the COVID-19 disease is now competing with the emergence of increasingly contagious mutations, repeatedly supplanting earlier strains. Following the near-absence of historical examples of the long-time evolution of infectious diseases under similar circumstances, models are crucial to exemplify possible scenarios. Accordingly, in the present work we systematically generalize the popular susceptible-infected-recovered model to account for mutations leading to repeatedly occurring new strains, which we coarse grain based on tools from statistical mechanics to derive a model predicting the most likely outcomes. The model predicts that mutations can induce a super-exponential growth of infection numbers at early times, which self-amplify to giant infection waves which are caused by a positive feedback loop between infection numbers and mutations and lead to a simultaneous infection of the majority of the population. At later stages—if vaccination progresses too slowly—mutations can interrupt an ongoing decrease of infection numbers and can cause infection revivals which occur as single waves or even as whole wave trains featuring alternative periods of decreasing and increasing infection numbers. This panorama of possible mutation-induced scenarios should be tested in more detailed models to explore their concrete significance for specific infectious diseases. Further, our results might be useful for discussions regarding the importance of a release of vaccine-patents to reduce the risk of mutation-induced infection revivals but also to coordinate the release of measures following a downwards trend of infection numbers.
Tuned MWCNT/CuO/Fe3O4/Polyaniline nanocomposites with exceptional microwave attenuation and a broad frequency band
Authors: Afzali Saeedeh-Sadat , Hekmatara Seyedeh Hoda , Seyed-Yazdi Jamileh , Hosseini Seyed Mohammad Bagher Malek
Published: June 2022

In this study, novel quaternary MWCNT/CuO/Fe3O4/PANI nanocomposites were synthesized with three different weight ratios of CuO/Fe3O4/PANI to MWCNT (1:3), (1:4), and (1:5), where all of its components were synthesized separately and then combined in specific weight ratios. CuO/Fe3O4/PANI transmission electron microscopy (TEM) images revealed that most nanoparticles were in a CuO/Fe3O4 hybrid form, with a narrow size distribution uniformly dispersed in a polymer background. The TEM and scanning electron microscopy (SEM) images of the MWCNT/CuO/Fe3O4/PANI nanocomposite revealed that the MWCNT was uniformly coated with CuO/Fe3O4/PANI. All three nanocomposites samples demonstrated superior microwave attenuation performance in terms of reflection loss and absorption bandwidth. The minimum reflection losses for MWCNT/CuO/Fe3O4/PANI nanocomposites (1:3), (1:4), and (1:5) were 45.7, 58.7, and 85.4, 87.4 dB, respectively. The absorption bandwidths (RL ≤ −10 dB) of MWCNT/CuO/Fe3O4/PANI nanocomposites (1:3), (1:4), and (1:5) were 6, 7.6, and 6 GHz, respectively.