bluuebunny/crossref_metadata_2025 huggingface dataset:
PRELIMINARY PHYTOCHEMICAL SCREENING AND IN VITRO ANTI-MICROBIAL ACTIVITY OF ETHANOLIC EXTRACTS OF FRUITS OF ANNONA RETICULATA AGAINST STANDARD PATHOGENIC STRAINS
Authors: Paul Sujata , Dash Biswajit , Bora Aditya Jyoti , Gupta Bikash
Published: July 2018

Objective: To evaluate the anti-microbial activity of ethanolic extract of fruits of Annona reticulata (family-Annonaceae) in conjugation with phytochemical analysis.Methods: The ethanolic extract of fruits of Annona reticulata (family-Annonaceae) was prepared by Soxhlet extraction and analysed for phytochemical constituents using standard methods. The anti-microbial activity of the plant extract was examined against bacterial strains and fungal strains using disc diffusion method.Results: The present investigation shows the phytochemical analysis, anti-microbial activity of the ethanolic extract of the plant Annona reticulata. Various phytochemical analyses revealed the presence of alkaloids, saponin, flavonoids, carbohydrates, glycosides, steroids, proteins and amino acids and tannins. The anti-microbial activity of the ethanolic extract of the plant showed significant result against all the of the test organisms.Conclusion: The present study concluded that ethanolic extract of fruits of the Annona reticulata contain high presence of phytochemicals. The ethanolic extract of the plant was found to possess promising anti-microbial activity when compared with the standards.
NANOPLEX: A REVIEW OF NANOTECHNOLOGY APPROACH FOR SOLUBILITY AND DISSOLUTION RATE ENHANCEMENT
Authors: Kasar Poonam Madhukar , Kale Kalyani Sundarrao , Phadtare Dipti Ganesh
Published: July 2018

The use of nanotechnology based on the development and fabrication of nanostructures is one approach that has been employed to overcome the challenges involved with conventional drug delivery systems. Formulating Nanoplex is the new trend in nanotechnology. Nanoplex means drug nanoparticle complex with the oppositely charged polyelectrolyte. In this technique, the cationic or anionic drug is reacted with an oppositely charged polyelectrolyte to form a complex. Compared with other nanostructures, the yield of Nanoplex is greater and the complexation efficiency is better. The nanoplex formed shows improved solubility and dissolution rate compared to raw drug crystals. Nanoplex formulation is characterized through the production yield, complexation efficiency, drug loading, particle size and zeta potential using scanning electron microscopy, differential scanning calorimetry, X-ray diffraction and dialysis studies. Nanoplex have wide-ranging applications in different fields such as cancer therapy, gene-drug delivery, drug delivery to the brain and protein and peptide drug delivery.
PRELIMINARY PHYTOCHEMICAL SCREENING AND TO EVALUATE THE ANTHELMINTIC ACTIVITY OF HYDRO-ALCOHOLIC AND PETROLEUM ETHER EXTRACT OF NYCTANTHES ARBOUR-TRISTIS ROOT. (FAMILY-NYCTAGINACEAE)
Authors: Abdullah Akm , Das Sumit
Published: July 2018

Objective: To estimate the anthelmintic activity of hydro-alcoholic (methanol) and petroleum ether extract of Nyctanthes arbour-tristis (family-Nyctaginaceae) in conjugation with phytochemical screening.Methods: The hydro-alcoholic and petroleum ether extract of the whole root part of the plant Nyctanthes arbour-tristis (family-Nyctaginaceae) was prepared. And studies Phytochemical constitutes by the various standard method. The anthelmintic activity of the plant was performed by a different extract of plant material were tested against adult Indian earthworms pheretima posthuma as test worms, the bioassay determines the time of paralysis and time of death. Albendazole is used as a standard reference drug.Results: The present study shows the phytochemical analysis, the anthelmintic activity of the hydro-alcoholic and petroleum ether extract of the root of Nyctanthes arbour-tristis. Various phytochemical analyses revealed the presence of alkaloids, carbohydrates, flavonoids, tannin, phenol,, glycosides, saponins respectively. The anthelmintic activity of the plant extract showed significant results against all earthwormsConclusion: The study has shown that petroleum ether and methanolic extract of Nyctanthes arbortristis root have significantly determined anthelmintic activity. But the methanolic extract of Nyctanthes arbortristis root shown most significant anthelmintic activity as compared to petroleum ether extract.
PROSPECTIVE AND RETROSPECTIVE ANIMAL MODEL USED IN THE PHARMACOLOGICAL SCREENING OF ANTI-CANCER DRUG
Authors: Ahmed Shamima Nasreen , Das Biswajit , Chakraborty Jashabir
Published: July 2018

Cancer is a disease characterized by uncontrolled proliferation of cells that have transformed from the normal cells of the body. The widely used cancer drugs suffers from the drawback of high toxicity not within the reach of a common man. This urgently necessitating the screening of these compounds. This review focuses on the major contributions of preclinical screening models to anticancer drug development over the years till recent times, from the empirical drug screening of cytotoxic agents against uncharacterized tumor models to the target-orientated drug screening of agents with defined mechanisms of action,, a general transition has been observed. The newer approaches to anticancer drug development involve the molecular characterization of models along with an appreciation of the pharmacodynamics and pharmacokinetic properties of compounds [e. g., the US National Cancer Institute (NCI) in vitro 60-cell line panel, hollow fibre assay, and s. c. xenograft]. In vivo tumor models including orthotopic, metastatic, and genetically engineered mouse models are also reviewed. The preclinical screening efforts of the European are also included. In 2015 with the rapid development of cancer modeling in zebrafish, great opportunities exist for chemical screens to find anticancer drug since 1970 the European Organisation for Research and Treatment of Cancer and Cancer Research UK, have been collaborating with the NCI in the acquisition and screening of compounds.
PERKEMBANGAN ONTOGENETIK DAUN TANAMAN KARET SEBAGAI PENANDA AWAL ADAPTASI TERHADAP CEKAMAN LINGKUNGAN DAN PATOGEN
Authors: Junaidi Junaidi , Atminingsih Atminingsih
Published: July 2018

Clonal rubber leaves vary in shape, size, morphology and anatomy. Leaves development stages can be distinguished as A, B, C and D phase. In stage A, the leaflet hang vertically toward petioles. In stage B their color are light brown green with soft texture. In stage C, the leaflets are almost fully grown with firm laminae. In stage D, the leaflets have fully developed in nearly horizontal position. Physiologically, stage A and B are sink while stage C and D are source. The shorter transition from sink to source in new leaves is important response to environmental stress and pathogen. Therefore, leaves ontogenetical development can be used as early marker of plant adaptability to environment. Similar researches are necessary to be carried out using Indonesian specific clones and environment.
PERSEPSI MAHASISWA PRODI PENDIDIKAN BAHASA INGGRIS UIN AR-RANIRY TENTANG PLAGIARISME TUGAS KULIAH
Authors: Bahri Syamsul , Trisnawati Ika Kana
Published: July 2018

This study aimed to investigate the student perceptions of plagiarism and the reasons that led to plagiarism in the students’ assignments. The population of the study included the students of English Education Department at UIN Ar-Raniry Banda Aceh, with 166 students randomly selected as the sample. Questionnaire was used as the instrument for collecting data. The data were then analyzed with the SPSS in order to obtain their descriptive statistics. The results of the study showed that there were various students’ perceptions about the notion of plagiarism and the underlying reasons for their plagiarism. It was generally understood that plagiarism wa the use of words/ideas of others recognized as one’s own. Further, the major causes of plagiarism in the assignments were due to lack of English language skills and lack of time management. In addition, the behaviors of lecturers and the university involvement in socializing the concept of plagiarism also became the causes for the higher proportion of academic dishonesty among the students. These findings are expected to be the input for the creation of campus policy so that academic integrity and better lecture system can be achieved in any university.
PREFÁCIO
Authors: SPERBER Suzi Frankl
Published: July 2018

.
APRESENTAÇÃO
Authors: Deplagne Luciana Eleonora de F. Calado , Vianna Luciano José
Published: July 2018

Resumo
POLÍTICAS PÚBLICAS PARA COMUNIDADES QUILOMBOLAS: uma luta em construção
Authors: Silva André Ricardo Fonseca da
Published: July 2018

O presente artigo trata da construção de políticas públicas para comunidades quilombolas, dialogando com a história
dos africanos, a partir da travessia do Atlântico, com o interesse do capital no modo de produção escravocrata,
que fora muito usado no Brasil na época da colonização portuguesa. Além disso, analisa as políticas públicas específicas
construídas no contexto brasileiro para os quilombolas, dando ênfase ao Programa Brasil Quilombola. Para
o desenvolvimento da pesquisa fizemos uso da abordagem qualitativa; concomitantemente, foi feito uso da historiografia
para entendermos a ressemantização da palavra quilombola. Além disso, utilizamos o método histórico
para reconstruirmos a história do artigo 68 do ADCT da Constituição Federal de 1988. Fizemos também consultas
a dados primários e secundários de órgãos públicos. Concluiu-se que a regularização fundiária definitiva junto
com a concretização de políticas públicas específicas são o caminho para construção da cidadania quilombola, pois
permitirá que haja uma segurança jurídica para os quilombolas.
Palavras-chave: Políticas Públicas. Quilombolas. Cidadania. Escravidão.
Comunidades Quilombolas sob a perspectiva da transição demográfica
Authors: Brandão André Augusto , Dos Santos Nilton Cesar , Jorge Amanda Lacerda
Published: July 2018

Este artigo objetiva discutir a configuração demográfica atual das comunidades quilombolas brasileiras em relação ao perfil da transição demográfica verificado para o conjunto da população nacional nas últimas décadas. Os dados que utilizamos para a composição deste estudo derivam dos censos demográficos nacionais e de uma pesquisa realizada em 2011 que coletou informações populacionais e socioeconômicas no conjunto das 9191 famílias que habitavam as 169 comunidades quilombolas que até 2010 haviam obtido o título definitivo de propriedade de seus territórios. Com a análise comparada dos dados, foi possível identificar em que variáveis a população quilombola se afasta ou se aproxima do perfil demográfico nacional. Na conclusão mostramos que, se por um lado esta população específica ainda não completou o seu processo de transição demográfica, começa a apresentar fortes tendências nesta direção.
A JUSTIÇA RESTAURATIVA COMO PROCESSO EDUCATIVO DE RESISTÊNCIA AO ITINERÁRIO PENALIZADOR DIRIGIDO AOS JOVENS DA PERIFERIA URBANA
Authors: De Lima Cezar Bueno , Boneti Lindomar Wessler
Published: July 2018

O objetivo do artigo é compreender o fenômeno da violência juvenil urbana a partir de reflexões teóricas que
evitam explicações monocausais da violência e da erosão da lei sem, entretanto, ocultar ou menosprezar o fato
de os jovens oriundos das classes sociais subalternas constituírem o núcleo preferencial da atuação policial e do
sistema de justiça juvenil. O estudo sugere a necessidade de implementação do modelo de justiça restaurativa como
processo educativo vinculado à produção de saberes, experiências e decisões numa dimensão participativa entre
os atores e órgãos implicados no processo, como estratégia de construção da autonomia e solução pacífica dos
conflitos, alinhada à defesa e promoção dos direitos humanos.
Palavras-chave: Violência Juvenil. Desigualdade. Direitos Humanos. Justiça Restaurativa.
ESTUDAR OS SINDICATOS, ENTENDER O BRASIL
Authors: Rodrigues Victor De Oliveira
Published: July 2018

A leitura de “O Sindicalismo na Era Lula: Paradoxos, Perspectivas e Olhares”, longe de esgotar o tema, ajuda a pensar justamente as “possibilidades de realização” de ação sindical. Trata-se de uma obra de grande fôlego e bastante atual. Um dos pontos fortes do livro é a pluralidade de perspectivas e orientações teóricas, que se reflete nas diferentes abordagens e, também, na escolha dos objetos de análise. Trata-se de uma leitura indispensável não apenas para os estudiosos do sindicalismo, mas, sem dúvidas, para todos aqueles que desejam compreender aspectos centrais do Brasil contemporâneo. Serão os sindicatos brasileiros capazes de responder à altura os desafios colocado pelo atual momento histórico?
Editorial
Authors: Boaes Giovanni , Oliveira Roberto Véras de
Published: July 2018

Apresentação do número 48 e acolhimento pelos editores.
Por uma abordagem ecológica e contextual da comunicação em tempos de midiatização profunda
Authors: Dall'agnese Carolina Teixeira Weber , Barrichello Eugenia Maria Mariano da Rocha
Published: July 2018

Neste texto discute-se a adoção das perspectivas da midiatização e da ecologia da mídia como possíveis bases para a investigação dos processos e práticas comunicacionais no ecossistema midiático contemporâneo. A partir da noção de complementaridade entre os dois aportes, defende-se a construção de percursos de pesquisa de abordagem ecológica e contextual para apreender as complexidades do cenário atual de midiatização profunda (COULDRY e HEPP, 2017), caracterizado pela crescente interdependência entre meios, instituições, organizações e indivíduos nos diferentes ambientes de mídia.

Palavras-chave: Midiatização. Midiatização profunda. Ecologia da mídia. Teorias da comunicação.
Interação, participação e deliberação online: o caso do website Vote na Web
Authors: Zanetti Lucas Arantes , Luzivotto Caroline Kraus
Published: July 2018

A internet e as ferramentas da web 2.0 proporcionam um ambiente participativo e interativo, com ferramentas que permitem uma nova relação entre os atores sociais, nova organização e formas de articulação, interação e acesso a informação sobre o debate público e social. A partir do exemplo do website Vote na Web, que propõe a participação do cidadão em assuntos de relevância nacional por meio de uma plataforma online, este artigo apresenta uma reflexão sobre a interação, a participação e a deliberação na internet, por meio do uso das ferramentas da web 2.0. Apos o estudo pode-se concluir que o website possui limitações e que as ferramentas online não são utilizadas em sua potencialidade. Mas, a partir de um contexto de cidadania e de participação online, é possível verificar que a arquitetura do website favorece a participação, mesmo sem o engajamento cívico, e que os processos comunicativos e interativos inerentes à essa plataforma online são um passo em direção a uma prática cidadã mais ampla.

Palavras-chave: Interação. Participação. Deliberação. Internet.
Otaku, Japanoido, Shinjinrui: relação afetiva com a imagem e os universos ficcionais do anime
Authors: Longo Angela
Published: July 2018

A partir do boom do anime nos anos 1990, o fenômeno otaku tem gerado reações diversas sobre recepção e consumo. O discurso sobre o otaku tende a oscilar entre duas noções: a de subcultura, por vezes com graus patológicos, e a noção cool japan da cultura mainstream. Iremos observar essas tendências na configuração do anime com os autores Tsugata Nobuyuki, Thomas Lamarre e Saitō Tamaki e nas teorizações sobre o otaku com os autores Tatsumi Takayuki, Okada Toshio e Azuma Hiroki. A nossa proposta é que a aproximação afetiva do otaku com o anime abre uma zona de autonomia dentro do movimento otaku.

Palavras-chave: Otaku. Japanoido. Shinjinrui. Anime.
A Gestão por Competências como Ferramenta para Contenção da Rotatividade de Estagiários em Empresas de Pesquisa.
Authors: Sudo Lutif Herickson Akihito
Published: July 2018

O objetivo deste trabalho é elaborar propostas de melhorias na contratação de estagiários nas empresas de pesquisa com o fim de evitar o aumento na taxa de rotatividade. Estudou-se a relação do analfabetismo funcional com as taxas de rotatividade de estagiários. Foram demonstradas considerações importantes que podem dar excelentes resultados tanto na contenção da taxa de rotatividade em empresas de pesquisa quanto na qualidade de formação de estágio, principalmente no que tange ao Programa de Treinamento Continuado. Propõe-se aqui um questionário para que no Processo Seletivo de estagiários criem-se melhores condições de conhecer os candidatos a estágio para efeito de uma proposta de treinamento contínuo e levantamento de competências dos candidatos a estágio. Verificou-se que poderiam ser implementadas a compatibilização do perfil do estagiário com o perfil da empresa.
A guarda terceirizada como integrante da gestão documental
Authors: Costa Graziela Da , Molin Bedin Sonali Paula
Published: July 2018

Aborda a questão da guarda documental terceirizada. O método utilizado foi apesquisa bibliográfica. Quanto à coleta de dados, utilizou – se da observação e do questionário, que serviram para verificar se o profissional responsável pelo arquivo tem conhecimento dos procedimentos realizados no mesmo.A pesquisa foi composta pelos responsáveis pelo arquivo e a escolha destes profissionais foi feita aleatoriamente. Na fundamentação teórica, foram abordadosos temas: Gestão documental, Etapas da Gestão Documental e Terceirização. Os resultados obtidos mostram que as empresas estão valorizando o arquivo e este deve ser mantido organizado, para que possa atender às necessidades de seus usuários.
Perspectivas arquivísticas em centros de memória
Authors: Santos Amanda Carvalho
Published: July 2018

Tendo como foco de estudo os centros de memória, o presente artigo tenciona apresentar as principais configurações, usos e significados dos conjuntos documentais de natureza arquivística custodiados nesses espaços, e a possibilidade de (re)configuração do documento arquivístico nesse contexto. São analisadas as características da formação e institucionalização dos centros de memória, e os desafios encontrados no processamento técnico dos seus acervos arquivísticos, que tem como principal particularidade uma composição colecionadora e heterogênea. O presente ensaio teórico faz parte de um processo de pesquisa que vem sendo desenvolvida no âmbito do Programa de Pós-Graduação de Documentos e Arquivos da Universidade Federal do Estado do Rio de Janeiro, e tem como principal fio condutor analisar o papel dos arquivos quando inseridos em centros de memória, ressaltando a importância da perspectiva arquivística no âmbito do processo de organização desses acervos.
Uma mão na Literatura, outra na Imprensa: breve análise do papel das crônicas no Jornal dos Sports
Authors: COUTO André Alexandre Guimarães
Published: July 2018

Este artigo procura discutir a importância que as crônicas passaram a ter para o Jornal dos Sports (JS) a partir da década de 1940 na cidade do Rio de Janeiro. Para tanto, dividimos nossa análise em quatro partes, sendo a primeira responsável por breves explicações sobre o periódico estudado além do levantamento de questões norteadoras da pesquisa. Em um segundo momento, nos dedicamos sobre as características gerais da crônica e o quanto estas foram bem exploradas pelo JS. A seguir, pensamos sobre as nuances específicas do cronismo esportivo, que interage de forma dialética entre a subjetividade autoral e a objetividade de uma imprensa que luta pela consolidação de seu processo de modernização ao longo da metade do século XX. Finalmente, poderemos observar exemplos da produção literária/jornalística de um dos cronistas mais duradouros e famosos do JS: Manoel Vargas Netto.
Jornalismo em contexto de violência: uma visão dos jornalistas do Jornal Noroeste, em Sinaloa, México
Authors: TEMER Ana Carolina Rocha Pessoa , ZAMORA Ana Rosalva Osuna
Published: July 2018

Este trabalho desenvolve uma análise sobre as condições para o exercício profissional do jornalismo no Jornal Noroeste, localizado no Estado de Sinaloa, na região noroeste do México, onde os profissionais de imprensa têm sido vítimas de ameaças e abusos supostamente perpetrados por organizações criminosas que tem vínculos com o narcotráfico e por suas ramificações no aparelho estatal. Tendo como ponto de partida o conceito do jornalismo como atividade essencial para a manutenção do Estado Democrático a análise busca diagnosticar como os profissionais de imprensa deste veículo compreendem e justificam a sua atividade profissional. O trabalho envolve entrevistas com jornalistas e dados coletados em entidades de defesa de classe no México e aponta como, mesmo reconhecendo o jornalismo como uma atividade de alto risco nesta região, os profissionais buscam se adaptar para continuar exercendo a profissão.
A EPISTEMOLOGIA DO DIÁLOGO SOCIAL NA COBERTURA SOBRE ABORTO NO PROGRAMA PROFISSÃO REPÓRTER: teoria e prática
Authors: SOUZA Marcelle Cristine de
Published: July 2018

Este artigo se trata de um relato de reportagem sobre aborto legal no programa Profissão Repórter, da TV Globo, e da aplicação de uma epistemologia que vê o jornalista como mediador social, conforme defende Cremilda Medina. O objetivo deste artigo é indicar uma possível saída para a crise de paradigmas que vive o jornalismo na atualidade. Tanto a prática quanto a teoria mostram que é necessário superar a suposta “objetividade” do jornalismo em prol da entrevista-diálogo, da reportagem em busca da complexidade e da narrativa de protagonismo. No caso concreto aqui desenvolvido, essas ferramentas foram utilizadas numa cobertura que mostra como o aborto legal ainda é um desafio para mulheres no Brasil.
A Influência da Metarreciclagem para Criação de um Produto Tecnológico
Authors: Da Silva Mateus Antonio , Soares Thales M.
Published: July 2018

A globalização influencia o aumento do comércio de eletrônicos e por consequência a geração da poluição eletrônica. Muitas vezes tratados como lixo comum, são desperdiçados materiais valiosos e que ainda podem ser utilizados para outros fins. A metarreciclagem tem como objetivo aproveitar o lixo eletrônico e dar utilidade para o que ainda funciona. O nosso objetivo é utilizar uma plataforma de hardware livre para o desenvolvimento de um jogo a partir de uma impressora. No trabalho é possível notar que a metarreciclagem é uma prática interdisciplinar, pois estimula a criatividade, design e mecânica. Além disso, contribui para o desenvolvimento de soluções tecnológicas, pelo barateamento de recursos e contribuição para a redução da poluição eletrônica no meio ambiente.
Curso Preparatório para a Olimpíada Brasileira de Informática
Authors: Fonseca Pinheiro de Lima Luiz Fernando , Anjos Eudisley G.
Published: July 2018

Em países Europeus e também nos Estados Unidos a inserção do ensino de linguagem de programação nos currículos escolares tem se tornado comum, o que se dá, principalmente, pelos grandes avanços tecnológicos que se tem vivenciado e pelas perspectivas existentes para o campo da computação. No Brasil, apesar de apresentar-se de forma mais branda, esse processo também pode ser observado por meio de algumas iniciativas como a Escola de Hackers, em Passo Fundo/RS, que proporciona o ensino de programação a alunos de escolas públicas e ainda escolas particulares que incluem essas aulas de maneira extracurricular no seu meio. Além disso, a Sociedade Brasileira de Computação promove uma competição à nível nacional, a Olimpíada Brasileira de Informática (OBI). A OBI é uma competição de raciocínio lógico e programação voltada para alunos de ensino fundamental, médio e superior. Em João Pessoa/PB nota-se algum investimento de escolas, principalmente particulares, para preparar alunos para tal competição. Desse modo, o projeto de extensão “Curso Preparatório para a Olimpíada Brasileira de Informática” do Centro de Informática da Universidade Federal da Paraíba, vem sendo executado por um grupo de professores e extensionistas desde 2008, com o intuito de preparar alunos, tanto de escolas públicas quanto privadas, para participar da OBI. No ano de 2017, o foco principal da execução do projeto foi na melhoria do material didático, na captação de novas escolas participantes e no início de novas turmas.
Three-component reaction of β-keto esters, aromatic aldehydes and urea/thiourea promoted by caffeine, a green and natural, biodegradable catalyst for eco-safe Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones derivatives under solvent-free conditions
Authors: Mohamadpour Farzaneh , Lashkari Mojtaba
Published: July 2018

Caffeine was found to be a natural and green and biodegradable catalyst for
the one-pot, three-component condensation Biginelli reaction of ?-keto
esters, aromatic aldehydes and urea/thiourea to afford the corresponding
3,4-dihydropyrimidin-2(1H)-ones/thiones derivatives under solvent-free
conditions. The remarkable features of this green procedure are high yields,
short reaction times, simplicity of operation and work-up procedures, the
availability and easy handling of this solid catalyst, avoidance of
hazardous or toxic catalysts and organic solvents and economic availability
of the catalyst.
Infective endocarditis of partial atrioventricular septal defect: A case report
Authors: Stefanovic Maja , Srdanovic Ilija , Milovancev Aleksandra , Susak Stamenko , Tadic Snezana , Ilic Aleksandra
Published: July 2018

Introduction. Partial atrioventricular septal defect (AVSD) is a form of congenital heart disease (CHD) rarely detected in adults. Infective endocarditis represents a severe complication that carries a substantial risk. Case report. We here reported a case of a 43-year-old female with previously diagnosed adult CHD (partial AVSD and bicuspid aortic valve) presented to the hospital with fever and malaise 14 days prior to admission. On the lung computed tomography scan inflammatory consolidations were found and dual antibiotic therapy (ceftazidime and clarithromycin) was administered without significant regression of pulmonary inflammatory consolidations. The antibiotic treatment was continued with amoxicillin/clavulanic acid combined with levofloxacin and metronidazole. Transthoracic and transesophageal echocardiography revealed a large vegetation (dimension, 3.6 x 1.8 cm) attached to the septal leaflet of the tricuspid valve floating between right atrium and right ventricle through tricuspid valve with high embolic potential. Endocarditis team reached a decision for immediate surgical intervention. The operative findings revealed the partial AVSD, common atrioventricular valve with cleft of the anterior mitral leaflet in the A2 segment and detached and cleft septal leaflet of the tricuspid valve. Vegetation (size 4 x 3 cm) was attached to the septal side of the tricuspid annulus, basal segment of the anterior mitral leaflet and edge of the atrial septal defect freely floating between right atrium, right ventricle and left atrium. Excision of the vegetation and AVSD plastics were done, as well as the reconstruction of the mitral and tricuspid annuli and leaflets. The treatment was continued with antibiotics and completed in 18 days with full recovery. Conclusion. Early and precious diagnosis and optimal management that combines both conventional and surgical approaches are crucial for reducing the risk of complications and mortality in patients with infective endocarditis in grown-up congenital heart disease.
Significance of cytogenetic-risk categories and refined international prognostic scoring system for overall survival in primary myelofibrosis: A single-center experience
Authors: Djordjevic Vesna , Dencic-Fekete Marija , Jovanovic Jelica , Soldatovic Ivan , Jankovic Gradimir , Bogdanovic Andrija
Published: July 2018

Abstract Background/Aim. Primary myelofibrosis (PMF) is a chronic, malignant hematological disease characterized by a leucoerythroblastic blood picture, anisopoikilocytosis teardrop- shaped erythrocytes, different degrees of bone marrow fibrosis and hepatosplenomegaly due to extramedullary hematopoiesis. Among genetic specificities of the disease, those that stand out are chromosomal aberrations in pathological, myeloid blood cells. The aim of this study was to examine the prognostic significance of clinical, hematologic and cytogenetic parameters in PMF. Methods. A retrospective study included 144 patients with PMF. Karyotypes were analyzed using conventional cytogenetic methods. Results. The chromosome examinations were successful in 126 (88%) patients and failed in the remainder ones (12%). Karyotype was abnormal in 36/126 (29%) subjects at presentation. The most frequent changes included +9, 13q- and 20q- (28%). Other abnormalities were: aberrations of chromosome 18 and 16, deletions (9q-, 12p-, 7q-, 5q-, 6q-, 8q-), trisomies (+1q, +8, +10, +21), monosomies (-7, -11), 3q inversion and loss of Y chromosome. We detected four novel balanced translocations in PMF: t(17;22)(q11;q13), t(15;17)(q22;q25), t(9;12)(q22;q24) and t(2;4)(q21;p16), one constitutional translocation-rob(13;14)(q10;q10) and some new karyotype anomalies ? deletion of both homologues, hyperdiploidy and the coexistence of unrelated pathological clones. Conclusion. Chromosomal aberrations had a significant influence on overall survival of patients with PMF according to the refined cytogenetic-risk of the International Prognostic Scoring System (Refined CIPSS) (p = 0.004). Our patients matched the pattern of chromosome aberrations usually observed in PMF but some newly registered, balanced translocations and other rare karyotype anomalies were recorded as well.
Presence of Tannerella forsythia in patients with chronic periodontal disease and atherosclerosis
Authors: Staletovic Danijela , Kannosh Ibrachim , Sehalic Meliha , Vukicevic Vladanka , Milojkovic Zoraida , Ilic Aleksandra , Pavlic Verica , Brkic Zlata
Published: July 2018

Background/Aim. Periodontal disease is an inflammatory disease that occur in the tissues surrounding the teeth in response to bacterial biofilm accumulation (dental plaque). Among others, Tannerela forsythia (Tf) was recognized as one of the most significant and specific bacterial species in periodontal pocket (?red complex? bacteria). Atherosclerosis is a progressive narrowing of arteries that may lead to occlusion, as a consequence of lipid deposition. It underlies coronary heart disease (80%), as well as myocardial and cerebral infarctions. Increasing evidence over the past decade suggests a link between periodontal disease and atherosclerosis, where Tf can enter the systemic circulation directly or indirectly, and be present in atherosclerotic blood vessels. Therefore, the aim of this study was to detect the presence of Tf in atheromatous plaques obtained from different blood vessels in patients with chronic periodontitis. Methods. Ninety patients (male 61, female 29) with periodontal disease and atherosclerosis [recruited for either carotid artery stenosis requiring endartectomy or percutaneous transluminal coronary angioplasty (PTCA)] were included in this study. Clinical periodontal examinations consisted of plaque index (PI) (according to Silness L?u), gingival index (GI) (according to L?e Silnes), sulcus bleeding index (according to M?hleman-Son) and periodontal probing depth (PPD). Presence of Tf in periodontal pockets and atherosclerotic vessels was detected using polymerase chain reaction (PCR) method with positive control Tf ATCC 43037. Results. Tf was present in subgingival plaques of 68 (75.6%) of the patients, while its presence in atheromatous plaques were registered in 42 (53.3%) of the patients. It was significantly present in coronary blood vessels (41.7%), followed by carotid arteries (35.4%) and a. abdominalis aneurism (12.5%), a. mamaria (8.5%) and a. femoralis (2.1%) while in a. iliaca Tf was not detected at all. Conclusion. The present study suggests strong relationship between periodontal inflammation and atherogenesis; therefore, it should be considered as potential risk factor for atherosclerosis. Accordingly, it would be necessary to control periodontal disease in order to reduce mortality and morbidity associated with atherosclerosis.
Incidence, in-hospital mortality and risk factors for hospital-acquired pneumonia in patients with intra-abdominal surgical procedures hospitalized in a tertiary hospital in Belgrade, Serbia: A matched case- control study
Authors: Tausan Djordje , Kostic Zoran , Slavkovic Damjan , Neskovic Branimir , Bokonjic Dubravko , Sipetic-Grujicic Sandra , Ratkovic Nenad , Suljagic Vesna
Published: July 2018

Background/Aim. Hospital-acquired pneumonia (HAP) in a surgical population significantly increases morbidity and mortality, prolongs hospitalization and increases total treatment costs. In the present study, we aimed to determine incidence, in-hospital mortality and risk factors (RFs) of HAP in patients with intra-abdominal surgical procedures hospitalized in a tertiary hospital in Belgrade (Serbia). Methods. Through regular hospital surveillance of patients who underwent intra-abdominal surgical procedures, we prospectively identified postoperative HAP during five years. In the matched case-control study, every surgical patient with HAP was compared with four control patients without HAP. In the group of patients with HAP, those who died were compared with those who survived. Results. Overall 1.4% of all intra-abdominal surgical patients developed HAP in the postoperative period. The incidence of HAP (per 1,000 operative procedures) was greatest in patients undergoing exploratory laparotomy (102.6), followed by small bowel surgery (36.6), and gastric surgery (22.7). Multivariate logistic regression analysis (MLRA) identified three independent risk factors (RF) associated with HAP: multiple transfusion [p = 0.011; odds ratio (OR): 4.26; 95% confidence interval (CI): 1.59?11.33], length of hospital stay (p = 0.024; OR: 1.02; 95%CI: 1.00?1.03) and hospitalization in the Intensive care unit (ICU) (p = 0.043; OR: 2.83; 95%CI: 1.03?7.71). MLRA identified only surgical site infection as an independent RF associated with the poor outcome of HAP (p = 0.017; OR: 5.929; CI95%: 1.37?25.67). Conclusion. The results of the present study are valuable in documenting the relations between RFs and HAP in patients undergoing intra- abdominal surgical procedures.
An equation for tacrolimus daily dose calculation in renal transplant patients - simple and cost saving?
Authors: Rancic Nemanja , Lozanov-Crvenkovic Zagorka , Mikov Momir , Vavic Neven , Dragojevic-Simic Viktorija
Published: July 2018

nema
Parameters of radical resection in laparoscopic and open colon and rectal cancer surgery
Authors: Krdzic Igor , Kenic Marko , Scepanovic Milena , Soldatovic Ivan , Ilic-Zivojinovic Jelena , Radovanovic Dragan
Published: July 2018

Background/Aim. In colon and rectal cancer surgery, resection is considered radical when circumferential, proximal and distal resection margins are without the presence of tumor cells. Concept of total mesorectal excision in rectal surgery involves complete removal of the tumor with mesorectal fascia which surrounds lymph nodes, lymphatics and blood vessels. The aim of this study was to determine whether laparoscopic approach provides all parameters of oncological radicality as open surgery of colorectal cancer. Methods. The study included 122 patients with carcinoma of colon and rectum, divided into two equal groups: patients operated on by laparoscopic and those operated on by open approach. In colon surgery we analyzed proximal and distal resection margins, and the number of removed lymph nodes, and in rectal surgery: proximal, distal and circumferential resection margins, and the number of removed lymph nodes. Results. Both groups were comparable in age, sex, American Society of Anesthesiologists (ASA) score, tumor localization, tumor size, and type of surgical operation performed. According to localization of the tumor, the most commonly performed operation was anterior resection of the rectum (60.7% vs. 59%). There was no case of the tumor involvement of the distal margin. Average proximal distance from the tumor on the fixed specimen was 100 vs. 120 mm with statistical significance (p < 0.001). Distal margins were not significantly different, 40 mm in both groups (p = 0.143). In two cases we had circumferential resection margin (CRM) of 1 mm (7.7%) in the laparoscopic group, and in three cases operated conventionally CRM was 1 mm (8.8%). The average number of removed lymph nodes was 15 vs. 16, respectively. Length of hospital stay for patients assigned to the laparoscopic surgery was significantly shorter than for patients operated on by the open approach. Concerning postoperative complications, no significant difference was found between groups. The overall postoperative morbidity was 18% vs. 21.3%, respectively. Conclusion. With laparoscopic approach it is possible to provide all parameters of oncological radicality similarly to the open surgery of colorectal cancer.
An Examination of the Interactive Effect of Feedback Source and Sign in the Offshoring Environment: A Social Identity Perspective
Authors: Andiola Lindsay M. , Downey Denise Hanes , Spilker Brian C. , Noga Tracy J.
Published: July 2018

Public accounting firms regularly rely on offshore professionals to assist with client work. However, differences in interpersonal dynamics between offshore staff members and the supervisors they report to may yield positive and/or negative work outcomes. We examine how feedback source (offshore or onshore supervisor) and feedback sign (negative or positive) interact to affect offshore staff members' satisfaction with feedback. This is an important issue because subordinate satisfaction with performance feedback is a key determinant of future performance and turnover intentions. We find that offshore staff members are less satisfied with negative feedback from an offshore (local Indian) supervisor, a member of their in-group, than an onshore (remote U.S.) supervisor, a member of their out-group. However, their satisfaction with positive feedback does not significantly differ between feedback sources. Further analysis reveals that greater satisfaction is associated with increases in the effort the staff member plans to put forth in the future.

JEL Classifications: M40; M41; M54; D91.

Data Availability: Please contact the authors.
Avoiding China's Capital Market: Evidence from Hong Kong-Listed Red-Chips and P-Chips
Authors: Jia Weishi , Pownall Grace , Zhao Jingran
Published: July 2018

The purpose of this paper is to explore the puzzle of why so many Chinese firms eschew listings in China. Hundreds of firms founded in China have reorganized themselves as overseas corporations and listed on the Hong Kong Stock Exchange. These firms are called Red-chips if they are state-owned enterprises (SOEs) and P-chips if they are not state-owned (non-SOEs). To examine the rationale behind the listing decisions of P-chips and Red-chips, we compare the characteristics of Red-chips (P-chips) with SOEs (non-SOEs) listed on China stock exchanges. We find that SOEs are more likely to list in China. Moreover, while we do not observe any significant difference between the performance of Hong Kong-listed and mainland-listed SOEs, we find non-SOEs that are listed in Hong Kong are significantly more profitable than those listed in China. We then explore three possible explanations for why Chinese firms, especially non-SOEs, may prefer to be listed in Hong Kong: (1) to facilitate personal wealth transfers out of China, (2) to increase access to debt capital, and (3) to facilitate more efficient stock price formation. We find that all three of these explanations have statistical support.
Effects of Speed on Tire–Pavement Interaction Noise (Tread-Pattern–Related Noise and Non–Tread-Pattern–Related Noise)
Authors: Li T. , Feng J. , Burdisso R. , Sandu C.
Published: July 2018

Tire noise is mainly generated from the interaction between tire and pavement. Different combinations of tire and pavement usually generate noise of different levels and different frequencies. For the same tire and same pavement, the most important factor influencing the noise level is vehicle speed. To provide a detailed description of the effects of speed on the noise generation, the present study investigates the tire noise of nineteen tires of the same size but with different tread patterns. The study includes the standard reference test tire and four other normal patterned tires running on a nonporous asphalt pavement using an on-board sound intensity (OBSI) technique. This OBSI system also has an optical sensor to monitor vehicle speed and to perform order-tracking analysis. The field tests were conducted under different vehicle speed values (72-105 km/h; i.e., 45-65 mph). The effects of speed on the noise spectrum and on the overall noise level have been analyzed. In addition, using the optical sensor signal, the tire noise related to the tire tread pattern has been isolated from noises from all other sources. The effects of speed on the separated signals have also been investigated. It was found that increasing speed increases the frequencies and levels of tread-pattern–related noise component, while for the noise component not related to the tread pattern, increasing speed only increases its amplitude, not its frequency. In addition, the noise generated at the trailing edge of the contact patch is more sensitive to the speed than the one at the leading edge.
Combination of short and ultrashort pulse laser processing for productive large scale structuring of 3D plastic mould steel
Authors: Brenner Andreas , Kurzidim Fabian , Fornaroli Christian , Gillner Arnold
Published: July 2018

Surface functionality is an increasing and crucial factor for the success and acceptance of a product. Through structured surfaces, products can gain additional functions: for example, friction reduction in combustion engines and bearings or optimizing lighting efficiency in light-emitting diodes. Furthermore, not only technical properties but also optical and haptic functions can be generated by surface structuring. Especially in the area of consumer products, these functions determine essentially the product quality. The most common way to create surface functionality in mass production is replication processes via structured mold tools. Currently used manufacturing processes for tool structuring like photochemical etching are limited in precision (manual preparation and execution) and in flexibility (limited design). This is the reason why laser ablation with (ultra-) short laser radiation is becoming an increasingly important technology that is able to generate structure sizes in the range of several hundred nanometers to several hundred micrometers. In this paper, the possibility of combining nanosecond (ns) pulsed laser radiation with picosecond (ps) pulsed laser radiation for microstructuring is investigated. This approach promises an increase of the productivity of the manufacturing process, similar to the strategy of roughing and finishing in milling processes. Within a first laser process, the workpiece is pretreated by short nanosecond laser pulses and a large amount of the volume is removed. A second, following laser process using picosecond pulses is utilized to ablate the remaining volume and to finish the surface by fabricating precise microstructures. This combination brings the advantages of both processes together: (comparable) short processing time (short pulses = roughing) while achieving high precision (ultrashort pulses = finishing). Main research activities presented are different approaches for combination strategies, discussions about achievable and from industrial site acceptable processing times, and accessible surface qualities for the combined process.
Penampilan Tebu dari Benih Bagal dan Budchip pada Dua Tata Tanam di Lahan Kering
Authors: , Djumali , , Lestari , Supriyono Dan
Published: July 2018

Sugarcane and replanting programs require a lot of seed cane and can not be fulfilled from  budsetts. To fill  up the gap the use of budchip seedlings  is suggested. The appropriate planting arrangement for budchip seedling has not been studied thoroughly. The study was conducted at the Asembagus Experimental Station, Situbondo, East Java, from January to December 2014 for the plant cane (PC) and from January to December 2015  for ratoon  cane (RC). Research was arranged in a randomized block design with three replications. The treatments consisted of (1) single budsett in single row planting, (2) double budsetts in double rows planting, (3) single budchip in single row planting, (4) single budchip in double rows planting, and (5) double budchips in double rows planting. The results showed the budchip seedling increase productivity 14.46-15.46%, sugar yield 18.17-23.38%, and profit 873% from budsett seedling. Double rows planting with budchip seedling increase productivity 52.11-61.01%, sugar yield 48.51-61.84%, and profit 603%  from single row planting. Double rows planting suitable for budchip seedling is  single budchip with productivity 52.53-88.30 ton ha-1, sugar yield 3.69-8.17 ton ha-1 and profit IDR 9,123,000 ha-1 per year.

Keywords: growth, planting material, productivity, Saccharum officinarum, sugar yield
Efficiency of Genetic Transformation via Pollen-Tube Pathway of Jatropha (Jatropha curcas L.) Based on Histochemical and Molecular Analysis
Authors: Zainudin Agus , Purwoko Bambang Sapta , Santoso Tri Joko , Ardie Sintho Wahyuning , Trikoesoemaningtyas And
Published: July 2018

The genetic transformation via pollen-tube pathway is an alternative method to overcome the constraints imposed by genotype specificity in transformation and regeneration in jatropha (Jatropha curcas L.) tissue culture. Therefore, it is necessary to establish important parameters for efficient genetic transformation of jatropha via pollen-tube pathway. The objective of the research was to study the efficiency of direct transformation of jatropha via pollen-tube pathway based on histochemical and molecular analysis. Solution of purified pCAMBIA1301 DNA plasmid carrying a hptII marker gene and a gus reporter gene with concentration level of 0.05, 0.25, 0.50 µg µl-1 were applied to stigma of flowers at 1, 2, 4, 7, 10 h after pollination. Seedling of IP3A, IP3P and JcUMM18 jatropha’s genotypes derived from 15 combination treatments of plasmid DNA concentration and application time, also wild type was subjected to histochemical and molecular analyses. Based on those analyses, the efficiency of transformation via pollen-tube pathway of three jatropha genotypes ranged from 1.5-16.7%. PCR analysis showed that a number of positive plants were identified by using specific primers hptII and gus, i.e. 1-3 and 3-7 plants of the 15 combined treatments, respectively. It indicated that the transformation efficiency via the pollen-tube pathway varied in each jatropha genotype.

Keywords: Jatropha curcas L., pCAMBIA1301, plasmid DNA, stigma-drip