bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Local Injection of Bevacizumab against Triple-Negative Breast Cancer Xenograft Tumors
Authors: Jiang Xin , Zhang Qiao-Li , Liu Tie-Gang , Zhao Wei-Peng , Yang Ming , Wang Li-Na , Sun Wei-Liang , Pan Lin , Luo Ai-Ping , Huang Jin-Chang , Gu Xiao-Hong
Published: March 2019

Background and objective:

Bevacizumab (BVZ) is a recombinant humanized antibody that inhibits the vascular endothelial growth factor A (VEGFA) and is used for the treatment of various types of cancer. BVZ is primarily given by the intravenous drip (I.V.), which often leads to low efficacy and various side effects. Therefore, the present study was to evaluate the effect of local delivery of BVZ against triple-negative breast cancer (TNBC) xenograft tumors.

Methods:

Mice 4T1 TNBC cells were engrafted in female BALB/c mice. After the tumors reached about 5 mm (diameter), animals were treated with BVZ through the local injection from four directions around the tumors. The tumor growth, survival and potential mechanisms of action were evaluated.

Results:

The growth and microvessel density of engrafted tumors were dramatically reduced with the tumor inhibition rate of 32.8 ± 3%. No obvious side effects were observed. The expression of VEGFA, VEGF receptor (VEGFR), matrix metalloproteinase (MMP)-2, MMP-9, Delta-like ligand 4 (DLL4) and Integrin-5 was significantly reduced in TNBC tumor tissues. In contrast, tissue inhibitor of matrix metalloproteinase (TIMP)-2 was significantly upregulated in xenograft tumors. Additionally, local delivery of BVZ led to the reduction of VEGFA and tumor necrosis factor (TNF)-alpha in the serum. Protein-protein interaction (PPI) analysis revealed that the proteins altered by the local delivery of BVZ were associated with angiogenesis and regulation of cell migration.

Conclusion:

This study provided evidence associated with local delivery of BVZ against TNBC tumors supporting the use of BVZ local injections to overcome some of the disadvantages associated with I.V. therapy with BVZ.
Facile Synthesis and Cytotoxicity of Phenazine-Chromene Hybrid Molecules Derived from Phenazine Natural Product
Authors: Zhang Mei-Chen , Gu Shu-Hui , Liu Guang-Pan , Li Chen-Cheng , Xu Han-Mei , Wu Zhong-Xi , Ye Bo-Ping , Lu Yuan-Yuan , Huang De-Chun , Wang Zhi-Xiang , Jiang Feng
Published: March 2019

Aim and Objective:

Small molecule targeted drugs can effectively reduce the toxicity
and side effects of drugs, and improve the efficacy of drugs by their specific antitumor activity.
Hence, the development of small molecular targeted drugs for cancer has important significance.
This study was undertaken to design and synthesize novel phenazine-chromene hybrid molecules
in order to optimize the structure and improve the efficacy of this kind of hybrids.

Materials and Methods:

O-diaminobenzene was used as starting material to synthesize twentyfour
heterocyclic compounds designed as hybrid molecules of phenazine and 4H-chromene
pharmacophores by facile methods. The structures of the compound were confirmed by 1H NMR,
13C NMR and HRMS. Furthermore, the synthesized compounds were evaluated for in vitro activity
against four human cancer cell lines and two non-cancer cell lines by MTT test.

Results:

Some compounds showed strong cytotoxic activities against HepG2 and A549 cancer
lines (IC50 = 5-10 µM). Comparing 2i with 2l, the introduction of hydrophilic groups on the
phenazine core could not improve the antiproliferative activity significantly. Except 2d and 3c,
compounds owning chlorine substituent on the 4H-chromene pharmacophore seemingly contribute
to enhance the compounds’ antiproliferative activity. Specially, compound 3c showed highest
cytotoxicity against A549 cells with IC50 values of 3.3±0.4 µM. Furthermore, all compounds
showed low or no cytotoxicity against HUVEC and L02 non-cancer cells in vitro.

Conclusion:

Compound 3c may be used as potential lead molecule against A549 cancer cells.
In-Silico QSAR Modelling of Predicted Rho Kinase Inhibitors Against Cardio Vascular Diseases
Authors: Kesar Seema , Paliwal Sarvesh , Sharma Swapnil , Mishra Pooja , Chauhan Monika , Arya Richa , Madan Kirtika , Khan Shagufta
Published: March 2019

Background: :

Rho-kinase is an essential downstream target of GTP-binding protein RhoA, and
plays a crucial role in the calcium-sensitization pathway. Rho-kinase pathway is critically involved in
phosphorylation state of myosin light chain, leading to increased contraction of smooth muscles. Inhibition
of this pathway has turned out to be a promising target for several indications such as cardiovascular diseases,
glaucoma and inflammatory diseases.

Methods::

The present work focuses on a division-based 2D quantitative structure-activity relationship
(QSAR) analysis along with a docking study to predict structural features that may be essential for the enhancement
of selectivity and potency of the target compounds. Furthermore, a set of indoles and azaindoles
were also projected based on the regression equation as novel developments. Molecular docking was applied
for exploring the binding sites of the newly predicted set of compounds with the receptor.

Results: :

Results of the docked conformations suggested that introduction of non-bulky and substituted
groups in the hinge region of ROCK-II ATP binding pocket would improve the activity by decreasing the
bulkiness or length of the compounds.

Conclusion: :

ADME studies were performed to ascertain the novelty and drug-like properties of the designed
molecules, respectively.
Peripheral Oxidative Stress Markers in Patients with Bipolar Disorder during Euthymia and in Siblings
Authors: Tatay-Manteiga Amparo , Balanzá-Martínez Vicent , Bristot Giovana , Tabarés-Seisdedos Rafael , Kapczinski Flavio , Cauli Omar
Published: March 2019

Aims:

Oxidative stress is increased during the acute phases of bipolar disorder (BD). Our aim here was to analyze oxidative stress biomarkers in patients with BD during euthymia and their siblings.

Method:

A cross-sectional study was performed in euthymic patients with BD-I (n=48), unaffected siblings (n=23) and genetically unrelated healthy controls (n=21). Protein carbonyl content (PCC), total antioxidant capacity (TRAP), lipid peroxidation (TBARS) and uric acid were measured as biomarkers of oxidative stress in blood.

Results:

The antioxidant capacity (TRAP) was lower (p<0.001) in patients with BD compared to their siblings and controls, whereas no differences were observed in PCC, TBARS or uric acid. In patients, the concentrations of TRAP and TBARS were positively associated with the dose of valproic acid (p<0.05 and p<0.001, respectively). The concentrations of these biomarkers were not significantly associated with any of socio-demographic and clinical variables.

Conclusion:

A selective reduction in antioxidant capacity is present in BD during euthymia state, whereas other markers of oxidative stress are unaltered during euthymia. Siblings did not show any alterations in oxidative stress biomarkers. Oxidative stress might represent a state-dependent marker in BD. The association between treatment with valproic acid and oxidative stress markers in euthymia deserves further studies.
A Review and Analysis on Recent Advancements in Bubble Electrospinning Technology for Nanofiber Production
Authors: Patel Swayamprakash , Patel Gayatri
Published: March 2019

Background:

Multiple applications of nanofiber in various segments of science and technology
have sparked the interest of innovators to explore the innovative approaches for nanofiber production.
The bubble electrospinning technique is the most versatile and simplest approach to scale up
the production of nanofiber at the industrial level. Numerous patent applications have been filed with
innovations and advancements in the field of bubble electrospinning technique.

Methods:

In present work, different patent applications in the field of bubble electrospinning technique,
which represents the advancement in bubble electrospinning technology, are searched and analyzed
using various paid and free patent databases. The patent search results are compiled, analyzed
and individual innovations are studied in detail to bring all the advancements hitherto in the bubble
electrospinning technology under the purview of one review article.

Results:

The “bubble ws3 electrospin” syntax in the structured search (TAC) facility of the patseer®
has revealed most relevant patents on advancement in bubble electrospinning. After applying the family
patent filter to the search result (33 patents), ten patents are selected for detailed study. The gist of
the invention from each of the patent application or granted patent is recapitulated in this paper, along
with their mosaics.

Conclusion:

Definite number of inventions are available in the field of bubble electrospinning technique.
Inventions, which are disclosed, might have their pros and cons with respect to ease of acceptance
by the industrial fraternity for large-scale production depending upon simplicity or complexity
of the instrument. There is a profound scope of innovation in the bubble electrospinning technology
in the areas like bubble stabilization, size and production rate control and much more.
Exploring the Main Characteristics of Turkish Firms Practicing Total Quality Methods
Authors: Yamak Kamil Oygur
Published: March 2019

This study paper reports the findings of a survey on Total Quality Management (TQM) in Turkey. The primary objective of this paper is to explore how the companies in Turkey plan, execute and control their processes towards a total quality management system and in doing that what characteristics they show and display. For this purpose a structured survey was conducted with the top 106 firms who either have applied or intend to apply for the Quality Prize awarded by Turkish Society for Quality. The following were specified as the aims of this study: to specify the typical behavioral attributes of Turkish firms who decide to improve their processes by TQM methods; to reveal the barriers to the TQM activities; to understand the significant changes in firm’s performances after TQM methods have been applied. The survey was conducted in cooperation with the Turkish Society for Quality.
Sistem Kesehatan Jiwa di Indonesia: Tantangan untuk Memenuhi Kebutuhan
Authors: Idaiani Sri , Riyadi Edduwar Idul
Published: March 2019

Abstrak

Sistem kesehatan jiwa yang baik akan menghasilkan masyarakat Indonesia yang sehat jiwa dengan ketersediaan pelayanan kesehatan jiwa yang bermutu, merata, tanggap, efisien dan terjangkau. Tulisan ini bertujuan untuk memberikan tinjauan sistem kesehatan jiwa di Indonesia beserta tantangannya. Studi ini merupakan kajian di bidang kesehatan jiwa. Informasi diperoleh melalui telaah kepustakaan, dokumen, curah pendapat, kunjungan ke lapangan dan wawancara terhadap pelaksana program jiwa. Hasil kajian memperlihatkan masih minimnya sumber daya kesehatan, pengeluaran biaya kesehatan yang masih rendah di Indonesia dibandingkan negara-negara tetangga. Sistem informasi kesehatan juga belum memadai. Kelebihan yang dimiliki Indonesia adalah adanya obat psikotropika yang cukup variatif dalam daftar obat esensial, memiliki Undang-Undang Kesehatan Jiwa, dan beberapa Peraturan Menteri Kesehatan yang menyangkut kesehatan jiwa. Meskipun memiliki Undang-Undang Kesehatan Jiwa, namun belum tersedia perangkat hukum dibawahnya untuk melaksanakan Undang-Undang. Peran serta sektor lain serta upaya promotif dan preventif belum dirasakan.

Kata kunci: sistem kesehatan jiwa, undang-undang kesehatan jiwa, sumber daya, sistem informasi, Indonesia

Abstract

A good mental health system will produce a healthy mental Indonesian community with the availability of good quality, equitable, responsive, efficient and affordable mental health services. This paper aims to provide a review of the mental health system in Indonesia and it challenges. This study is a review of mental health. Information is obtained through literatures and documents review, brainstorming, field visits and interviews with the implementers of the mental health program. The result shows that human resources, health expenditure are still minimal than neighbour countries. Health information system has not yet been adequate. The advantages of Indonesia are this country have adequate list of essential medicines, have a Mental Health Law and some Ministerial decree related to mental health. Although Indonesia has a Mental Health Law, but there has no legal devices available under the law to implement it. Other sector role’s and promotive, prevention program have not been felt.

Keywords: mental health system, mental health law, resources, information system, Indonesia
Pengembangan Model Latihan Gerak Pasif-Aktif Terhadap Pelayanan Rehabilitatif Pasien Stroke Hemiplegia RSUD dan RSI Fatimah Kabupaten Cilacap
Authors: Muttaqin Wahyu Wahid , Hidayatullah Furqon , Doewes Muchsin
Published: March 2019

Abstrak

Stroke merupakan gangguan fungsi saraf akut yang disebabkan oleh gangguan peredaran darah otak. Efek dari penyakit ini tidak hanya berdampak pada pasien tetapi juga keluarga dan lingkungan sekitarnya. Tujuan penelitian ini untuk mengembangkan model latihan gerak pasif–aktif yang efektif terhadap peningkatan aktivitas fungsional anggota gerak yang mengalami kelumpuhan pada pasien stroke di RSUD Kabupaten Cilacap. Rancangan penelitian menggunakan eksperimen semu pada bulan Maret 2017. Subyek penelitian ini adalah pasien stroke berjumlah 40 orang, terdiri dari 20 pasien stroke rawat jalan di RSUD Cilacap sebagai kelompok coba dan 20 pasien stroke rawat jalan di RSI Fatimah Cilacap sebagai kelompok kontrol. Intervensi berupa latihan gerak pasif-aktif yang dikembangkan sebelumnya untuk meningkatkan aktivitas fungsional yang diukur dengan Indeks Barthel. Analisis data menggunakan uji t. Pengaruh latihan gerak pasif-aktif dengan menggunakan buku panduan dan audio visual latihan stroke terbukti efektif diterapkan dalam pelayanan rehabilitasi di fasilitas kesehatan, peningkatkan hasil aktivitas fungsional tersebut diukur mengunakan Indeks Barthel.

Kata kunci: stroke, pasif-aktif, Indeks Barthel

Abstract

Stroke is acute nervous function disorder caused by brain circulatory disorders. The effects of this disease not only affect the patient but also the family and the surrounding environment. The purpose of this study was to develop an effective passive-active motion training model for increasing functional activity of limbs who experienced paralysis in stroke patients in Cilacap District Hospital. The research design used a quasi-experimental in March 2017. The subjects of this study were 40 stroke patients, consisting of 20 outpatient stroke patients in Cilacap Regional Hospital as the trial group and 20 outpatient stroke patients at Fatimah Cilacap Hospital as the control group. Interventions in the form of passive-active motion exercises that were developed previously to increase functional activity as identified by the Barthel Index. Data analysed using t test. The effect of passive-active motion examined by using a guide book and audio visual stroke exercises had effectively proved in rehabilitative health service facility, the improvement of functional activity results was examined using Barthel Index.

Keywords: stroke, passive-active, Barthel Index
A theoretical analysis of product versioning in the context of commercial piracy
Authors: Basu Paulomi , Banerjee Tanmoyee
Published: March 2019

The study develops a vertically differentiated duopoly model in the presence
of commercial piracy with two groups of consumers, a business group and a
home group, with the former having higher willingness to pay for the
product. A firm producing an original information good sells it with
endogenously chosen product quality and acts as a price leader, and the
commercial pirate becomes the price follower. There exists a stringent
government policy of monitoring commercial piracy, which increases the
marginal cost of the pirate. We study and compare the two regimes of
no-versioning (selling a single quality product) and product versioning
(selling products with different price and quality combinations to different
consumer groups). In the versioning regime, depending upon demand and
government monitoring parameters, two equilibria are observed. Comparing the
original firm?s profit in each of these versioning cases suggests that
versioning may or may not be the original firm?s optimal strategy in the
presence of commercial piracy. This result is counterintuitive to existing
literature on product versioning in the context of enduser piracy.
Standard Serbian stress and prefixation of adjectives and verbs
Authors: Desic Milorad
Published: March 2019

Debate on stress in prefixed words should take into account not only the
stress of the basic form of the prefixed lexeme but also the stress in other
forms. In this paper, stress in adjectives and verbs is divided into two
groups: lexical (comprising the two lexemes: the base word and the prefixed
one) and morphological (stress in other forms). Starting with lexical stress,
examples are classified into two large groups: the first group includes
examples of lexical stress on the stem of the prefixed word, while the second
one includes lexical stress on the prefix. Depending on the type of changes
in stress, adjectives are further classified into three subgroups: the first
subgroup includes examples where no changes in stress occur in either the
base or prefixed lexeme, the second includes the ones where change in stress
occurs only in the base word, whereas the third subgroup comprises examples
where changes in stress occur in both the base and prefixed lexeme. In verbs,
only one type of change in stress is found: a change related to both the base
and prefixed lexeme. The author analyzes the correlation between lexical and
morphological stress in a prefixed word, pointing out that the shift of
stress to the prefix is reversible: proclitic (moving from the stem with a
falling stress) and prefixal in a narrower sense (moving from the stem with a
rising stress).
Univerbation from the point of view of Serbian derivational morphology
Authors: Milasin Goran
Published: March 2019

This paper analyzes different meanings of the term univerbation in the
Serbian word-formation processes. The main goals were to investigate
different perspectives on univerbation in Serbian derivational morphology,
to compare it with the views in the Slavic, English and German papers and
dictionaries, and then to offer some potential solutions. In derivational
morphology, univerbation is usually defined as the process of transformation
of a syntactic construction as a motivator into a new single word. However,
when we consider examples of univerbation from Serbian word-formation
processes, we get an impression that it is not yet completely clear what
this process actually is, and what distinguishes it from the other
word-formation processes. One of the problems is the term univerbation (from
Latin unus - ?one? and verbum- ?word?), because it can be understood in
several ways - as a name of the process of combining two or more words into
a new single word: it can also include compounding, blending and syntactic
word-formation, not only one type of the processes as it is often the case
in Serbian derivational morphology. That is why we need to fi nd some better
term to name the process in which the motivator is a syntactic structure
adjective + noun, and a new word is made by adding some suffix on the base
of an adjective (saobracajna nesreca ? saobracajka). We propose that this
term can be deradixation, which suggests that a new word is made by
eliminating some free morphemes (radices) from a motivator.
Identification of phenolic and alcoholic compounds in wine spirits and their classification by use of multivariate analysis
Authors: Hanousek-Cica Karla , Pezer Martina , Mrvcic Jasna , Stanzer Damir , Cacic Jasna , Jurak Vesna , Krajnovic Mirela , Gajdos-Kljusuric Jasenka
Published: March 2019

During the ageing period wine spirits are changing their color, chemical composition and sensory characteristics. These changes should be simply monitored. The aim of this study was to develop partial least squares regression (PLS) models for higher alcohols and phenols in wine spirits as well as to show the feasibility of the NIR spectroscopy combined with chemometric tools to distinguish wine spirits and brandies with different ageing degree. To get the reference values, the usual methods for the analysis of spirits drinks were used. Ethanol, esters, acids, methanol and higher alcohols were studied. Wine spirits and brandies phenol composition was determined by liquid chromatography. Principal component analysis (PCA) was used to classify the wine spirits and brandies according to their phenolic and higher alcohols composition. Moreover, the Partial least squares regression (PLS regression) was used to calibrate and predict expected contents of higher alcohols and phenols in the wine spirits. Success of the classification of samples by ageing based on individual alcohols was 93.8 %, while success of the classification based on individual phenols raised to 100 %. This efficiency of the prediction was evaluated by use of linear discriminator analysis (LDA).
Does the JOBS Act Reduce Compliance Costs of Emerging Growth Companies? Theory and Evidence
Authors: Khurana Inder K. , Zhao Lei
Published: March 2019

In April 2012, the Jumpstart Our Business Startups (JOBS) Act was enacted to revitalize the initial public offering market by reducing regulatory burdens for small firms. We focus on audit fees, one directly observable and significant cost of complying with the JOBS Act. Specifically, we examine whether the exemption of emerging growth companies (EGCs) from SOX 404(b) auditor attestations of internal control over financial reporting and other disclosure requirements affected audit fees paid by EGCs. We find that EGCs paid higher audit fees than non-EGCs after IPOs. Moreover, we find that the positive relation between EGCs and audit fees is more pronounced for firms with high financial reporting risk. Collectively, our results reveal an unintended consequence of the JOBS Act: it failed to reduce audit fees, a major component of the compliance costs of EGCs.
KEEFEKTIFAN MEDIA SPOTLIGHT BOOK DENGAN MODEL SAVI TERHADAP KEMAMPUAN BERPIKIR KRITIS PADA MATA PELAJARAN IPS
Authors: Khoerunnisa Sofiana
Published: March 2019

This research aimed to identify and analyze the effectiveness of spotlight book media with SAVI model towards the critical thinking skill of students on IPS studies, 4th Grade of SD N Wangandalem 01 Brebes. This research was a quantitative research with research design that was Pre Experimental Design in the form of One Group Pretest-Posttest Design. The variable that used by researcher is dependent variable (attached) that was the critical thinking skill of students and independent variable (free) that was spotlight book media with SAVI model. The data collection of this research was giving 10 questions of critical thinking skill of students on pre-test and post test, for getting the different result of critical thinking skill of students between before and after doing that. For applying spotlight book media with SAVI model was obtained the enhancement result of average value of students’ critical thinking skill as much as 15.27% from 63.92 to 79.19.

Keywords: Critical thinking skill, Spotlight Book, SAVI
PENGARUH MODEL PEMBELAJARAN DENGAR-BACA-TULIS-UCAP TERHADAP HASIL BELAJAR DALAM PEMBELAJARAN KIMIA BILINGUAL PADA SISWA KELAS X
Authors: Yoga Kadek Tapa , Siregar Manimpan , Subagia I Wayan
Published: March 2019

Pembelajaran bilingual adalah pembelajaran yang dilakukan dengan menggunakan dua bahasa, yaitu Bahasa Inggris dan Bahasa Indonesia. Penelitian ini bertujuan untuk mengembangkan model PBBS yang dapat digunakan untuk pembelajaran bilingual di RSMABI. Pengujian model PBBS dilakukan melalui rancangan penelitian eksperimen semu tipe time series. Dalam penelitian ini diujikan model PBBS, yaitu model DBTU. Eksperimen ini dilakukan di SMA Negeri 2 Amlapura dengan melibatkan siswa kelas XB tahun ajaran 2011/2012. Hasil penelitian ini meunjukkan bahwa model pembelajaran DBTU dapat meningkatkan hasil belajar siswa. Namun demikian, peningkatan yang terjadi tidak sama pada setiap topik materi yang dieksperimenkan. Di samping hasil belajar yang diperoleh melalui pretes dan postes, hasil belajar yang diperoleh pada setiap tahapan pembelajaran yang melibatkan kegiatan mendengar, membaca, menulis, dan mengucapkan menunjukkan hasil yang baik. Bila dikomparasikan antara nilai pretes ke postes pada masing-masing topik materi pembelajaran terjadi peningkatan yang cukup signifikan. Pada topik kestabilan unsur ada kenaikan sebesar 9,69 dari 75,84 menjadi 85,53, pada topik ikatan ion serta sifat-sifat ikatan ion ada kenaikan sebesar 32,17 dari 55 menjadi 87,17 pada topik katan kovalen serta sifat-sifat ikatan kovalen ada kenaikan sebesar 52,24 dari 1,54 menjadi 53,78 pada topik polaritas ada kenaikan sebesar 42,26 dari 19,12 menjadi 61,38 dan pada topik katan logam ada kenaikan sebesar 55,28 dari 2,89 menjadi 58,17. Hal ini menunjukkan bahwa terjadi peningkatan nilai dari pretes ke postes yang terjadi pada penerapan pembelajaran bilingual bidang studi dengan model DBTU. Ini memberikan makna bahwa model yang dikembangkan dapat meningkatakn hasil belajar siswa.
Development of Entrepreneurship Intentions among School Students in Malaysia
Authors: Sheikh Ismail Afiah , Buang Nor Aishah
Published: March 2019

Entrepreneurial education in school has long been an effort by authorities in improving participation among school leavers in entrepreneurship. Still, there are clear obstacle in making this a reality. Thus this conceptual paper will discuss the obstacles and solutions towards of making entrepreneurial education a success. Obstacles that will be discussed are such as the lack of knowledge of entrepreneurship among teachers and the obsolete methods of teaching and learning currently practiced. Several solutions to the obstacles will be addressed are such as new pedagogical approaches such as games and simulations. Plus, solutions from the industry itself is put forward with activities such as engagement and attachment being highlighted. Therefore a model framework has been develop form the combination of elements from past theories and models which are Critical Experiential Incidence Model by Krueger(2007), Constructivism Theory by Vygotsky (1978) and Theory of Planned Behavior by Ajzen (1991).
SEKOLAH RAMAH ANAK BERBASIS HAK ANAK DI SEKOLAH DASAR
Authors: Ambarsari Luthfiana , Harun Harun
Published: March 2019

Abstrak: This research aimed to describe the child-friendly school policy in two child-friendly pilot primary schools. This research concern: “How does the implementation of child-friendly school policy based child rights at primary school?” The method that used in this research was a qualitative type of phenomenology. The data were collected by observation method, interview, and documentation. The data analysis technique that used was phenomenology research data analysis of Burke Johnson and Larry Christensen. The results showed that there were 3 discoveries related to child-friendly school policies in primary schools. First, the child-friendly school policies were designed and implemented to ensure children's rights were fulfilled. Second, the child-friendly school policies were implemented in learning area, the school social environments, the school’s physical environment, and infrastructure facilities. Third, the child-friendly school policies were applied to create condition conducive and fun in school.
KELEBIHAN DAN KELEMAHAN METODE TALAQQI DALAM PROGRAM TAHFIDZ AL-QUR’AN JUZ 29 DAN 30 PADA SISWA KELAS ATAS MADRASAH IBTIDAIYAH MUHAMMADIYAH
Authors: Diah Utami Ratnasari , Maharani Yosina
Published: March 2019

The purpose of this research is to identify 1) the advantages and weakness of talaqqi method in program tahfidz Al-Qur'an juz 29,30, and 2) Attempt to overcome the weakness of talaqqi method in program tahfidz Al-Qur'an juz 29,30, The type of research used in this study is qualitative descriptive. Data collection methods used in this study are the method of observation, interview and documentation. Validity of data used is triangulation method and triangulation of data source by using three step activity data analysis that is data reduction, data presentation, and conclusion. The results of this study indicate that 1) The advantages of talaqqi method is the motivation factor and habalan memorization of students which is still less so this method is considered very suitable and effective to be applied in the madrasah and students can read and memorize the Qur'an in accordance with the rules of science that tajwid correct. The weakness of the talaqqi method is derived from its own student factors that have not mastered the science of tajwid well such as short length, pronunciation makhraj, students who are easily bored so it will be joking with friends of their own. 2) Efforts made by teachers in overcoming the weaknesses of talaqqi method is to check the reading, control the development of memorization of students, listened one by one, come to the desk students who felt still have difficulty in memorizing, and by forming homogeneous classes tailored to the level of students' memorization skills.
Una lectura de los sueños diurnos y del inconsciente onírico del personaje de “Las violetas son las flores del deseo” de Ana Clavel
Authors: Plaza Morales Natalia
Published: March 2019

En este artículo analizamos el sueño y las fantasías diurnas del narrador-protagonista deLas Violetas son las flores del deseo (2007), novela perteneciente a la escritora mexicana contemporánea Ana Clavel. Estos elementos narrativos nos permiten profundizar mejor en la caracterización “perversa” del personaje de ficción de este relato. El funcionamiento del texto de Ana Clavel, que se revela de una gran intensidad fantasmagórica, evoca escenarios donde predomina una subjetividad multiforme del deseo que invita a ser descifrada. El deseo y la sexualidad son dos constantes en la narrativa de la autora y conforman una identidad original en su escritura.
Prado sin Ríos: espacios en el canon metaliterario de la narrativa de la memoria Prado
Authors: Escandell Montiel Daniel
Published: March 2019

La literatura de la memoria española de principios de siglo ha tenido muy presente el mundo artístico y literario en su retrato de la sociedad de finales del franquismo. Benjamín Prado, destacado autor de esta corriente, ha hecho especial énfasis en el mundo literario en sus novelas, incluyendo referencias a múltiples autores y sus obras, e incluso convirtiéndolos en personajes. Estas estrategias ayudan a formar el canon metaliterario fundamental. Este artículo aborda la ausencia de Julián Ríos tanto desde la perspectiva de una tradición de la ruptura como desde la presencia de esta en el canon metaliterario. Para ello tenemos en consideración la importancia del autor y su narrativa ya en la época en la que se ambientan estas novelas de la memoria, así como también el propio carácter experimental y memorístico de su escritura.
Carlos Edmundo de Ory y su inclusión en el canon de los clásicos. Un amor (im)posible
Authors: Parrado Collantes Milagrosa , Romero Oliva Manuel Fco.
Published: March 2019

El objetivo de este artículo se centra en estudiar la obra del escritor Carlos Edmundo de Ory y el canon literario desde las cuestiones presentadas por los diversos críticos literarios: la teoría de la influencia, el revisionismo o su permanencia en el tiempo. Partiendo del análisis de su obra Diario (1944 – 2010), como marco narrativo biográfico, llegamos al término suprafluencias para detallar aquellas influencias literarias, artísticas y de pensamiento fraguadas por el autor y forjadas a partir de su estela oryana. Los resultados evidencian la necesidad de considerar a este prolífico escritor dentro del canon de los autores clásicos.
Nombrarlas “moras”: personajes femeninos hechos de otredad en la literatura española del siglo xx
Authors: Romero Morales Yasmina
Published: March 2019

Este trabajo reflexiona sobre las diferentes designaciones que reciben los personajes femeninos marroquíes en la literatura española del siglo XX escrita por mujeres. De estos personajes femeninos se dice que son moras, árabes, musulmanas, bereberes, indígenas, rifeñas, sarracenas, beduinas, mahometanas o, simplemente, marroquíes. Una amplia gama de términos que apunta a categorías etnolingüísticas, religiosas o de procedencia, totalmente diferentes y que, por tanto, designan a distintos tipos humanos. Sin embargo, en esta narrativa analizada se utilizan casi de manera indistinta y, por ello, se busca reflexionar por qué razón.
Per speculum in aenigmate: juegos especulares en El país imaginado, de Eduardo Berti
Authors: Martínez Deyros María
Published: March 2019

En el presente trabajo estudiaremos el papel fundamental que desempeña el elemento sígnifico especular dentro de la narrativa de Eduardo Berti. Lo especular se constituye como la frontera que delimita el mundo real del irreal, y que confronta la alteridad con la identidad. Por otro lado, analizaremos cómo la especularidad es introducida a través de diferentes elementos fractales, presentes en todos los niveles (fonológico, léxico, sintáctico).
Narratives of Nationalism and the Conflict in Eastern Ukraine: Myth, Religion and Language
Authors: Clarke Jonathan E.M.
Published: March 2019

This paper offers a multidisciplinary approach to the study of the current armed conflict in Eastern Ukraine as a way of understanding the dispute and the failure of the warring parties to broker a lasting peace. It examines the ideological background to the conflict by considering the most significant historical myths that inform both sides, especially the myths surrounding the medieval state of Kievan Rus’, and the religious, political and linguistic elements of those myths that contribute to mutual misunderstanding and heightened tensions. What is demonstrated is that the myths of each side are structurally very similar: one set is the mirror image of the other (with corresponding labels interchanged). This symmetry helps to intensify and maintain inflamed confrontation, so that there is a pressing need to move beyond these myths, if a lasting peace is to be achieved.
Orwell’s List
Authors: Lotman Mihhail
Published: March 2019

Drawing on works of literature, especially ones written by Dostoyevsky and Böll, this essay discusses Orwell’s decision, at the height of the Cold War, to inform against suspected Leftist sympathisers.
The practice of authentic assessment in an EFL speaking classroom
Authors: Inayah Nurul , Komariah Endang , Nasir Abdin
Published: March 2019

The implementation of Curriculum 2013 has inserted the authentic assessment as the measurement method to evaluate students’ learning objectives and achievements in the classroom. In this curriculum, the application of authentic assessment requires teachers to evaluate students’ in three competencies: attitude, knowledge, and skill. Most teachers claim that speaking is the most difficult skill to be assessed by using the authentic assessment, considering the complex features of the assessment. This research was aimed at describing the application of authentic assessment in a speaking classroom which relates to the types of the assessment and the scoring rubric. The subjects of the study were an English teacher and 28 students of a class at one of the junior high schools in Banda Aceh. Under the descriptive qualitative approach umbrella, the data in this study was obtained from observation and document analysis. The results of the study revealed that the teacher used several types of activities to assess students’ speaking skills: (1) attitude assessment (teacher observation), (2) knowledge assessment (teacher interview/short answer question), and (3) skill assessment (narrating sequences). The result of this study indicates that authentic assessment is a feasible way to assess students’ speaking skill and it should be employed in assessing other skills as well for learning languages.
Analysis of error sources in L2 written English by Indonesian undergraduate students
Authors: Burhansyah Burhansyah
Published: March 2019

This study investigates second language learners’ production in writing, aiming to understand common problems the learners frequently have with English. The study focuses on the analysis of errors in 100 essays written by 50 Indonesian undergraduate students of English, which is aimed at identifying the commonly occurring errors, classifying them according to a linguistic category, and explaining the causes of the occurring errors. The study shows that a large number of the occurring errors resulted from intralingual sources, the proportion of which account for more than 60% of the total errors. The results conform to a number of earlier studies in this research field which concluded that the majority of errors L2 learners make stem from intralingual interference. Another possible explanation for the phenomena is that because the subjects participating in this study are university students majoring in English, they had at least mastered the basics of English when entering university. As a result, they are more likely to make fewer interlingual errors than students at elementary level who tend to rely more on their native language when dealing with the aspects of the target language which they have not yet mastered.
Uji Beberapa Konsentrasi Bakteri Bacillus sp. Endofit untuk Meningkatkan Pertumbuhan Bibit Kakao (Theobroma cacao L.)
Authors: Puspita Fifi , Saputra Sukemi Indra , Merini Dan Jenny
Published: March 2019

Development of cocoa (Theobroma cacao L.) requires high-quality seeds. Adding growth substance from Bacillus sp. endophytes is expected to increase the growth of cocoa seedlings. The purpose of this research was to evaluate the ability of Bacillus sp. endophytes to produce Indole Acetic Acid (IAA) hormone, evaluate the effects of Bacillus sp. endophytes application on growth of cocoa seedling, and obtain the best concentration to increase growth of cocoa seedling. The experiments were conducted in the laboratory and in the field from June to October 2015. The study was conducted in two stages: in vitro and in vivo.The first experiment tested the ability of Bacillus sp. endophytes to produce IAA using tryptophan enriched picovskaya liquid medium and non-enriched tryptophan. The results from the first experiment showed that all Bacillus sp. endophytes produce IAA hormones. The second experiment tested the concentrations of Bacillus sp. endophytes to improve the growth of cocoa seedlings. The experiment was conducted using a completely randomized design consisting of 5 treatments and 4 replications, i.e., without treatment of Bacillus sp., and concentrations of 1011, 1012, 1013, and 1014 cfu/mL. The parameters observed were the number of bacterial colonies of Bacillus sp. endophytes, cocoa seed height, stem diameter, number of leaves and planting area of 4 month cocoa seedlings. The results from the second experiment showed that all concentrations of Bacillus sp. endophytes increase the growth of cocoa seedlings. The concentration of 1011 cfu/mL produced more colony in planting medium, increased height, stem diameter, leaf number and leaf area in cocoa seedlings.
Optimasi Konsentrasi Asetosiringon dan Higromisin dalam Transformasi Genetik Padi Fatmawati dengan Perantaraan Agrobacterium tumefaciens
Authors: Sisharmini Atmitri , Purwoko Bambang Sapta , Khumaida Nurul , Trijatmiko Dan Kurniawan Rudi
Published: March 2019

Protocols for genetic transformation of rice have been widely developed, however the protocols are not universal and inapplicable for all types of rice plants directly. Transformation protocol on rice cv. Fatmawati needs to be developed to generate transgenic lines. The present research was carried out to optimize genetic transformation protocol in rice cv. Fatmawati mediated by Agrobacterium tumefaciens harboring pCambia1301 construct using immature embryo as an explant. The experiment was arranged in a completely randomized design. Factors influencing efficiency of transformation, i.e., sensitivity of callus to hygromycin antibiotic, acetosyringone concentration used in cultivation medium, hygromycin concentration for transformant selection were optimized. The results showed that genetic transformation of rice cv. Fatmawati mediated by A. tumefaciens using immature embryos have been successfully carried out with several parameters. Addition of 100 µM acetosyringone in co-cultivation medium and 30 mg L-1 hygromycin for transformant callus selection were optimal for genetic transformation of rice cv. Fatmawati mediated by A. tumefaciens. Transformation efficiency was found to be 7.84% based on the lines carrying the hpt gene. This result would be a valuable reference in genetic transformation of rice cv. Fatmawati using target genes.Keywords: immature embryo, Oryza sativa, pCambia1301, transformation efficiency
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Authors: Indonesia Jurnal Agronomi
Published: March 2019

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Proyecto de microzonificación sísmica de Neiva-Meta IV Sistematización de datos e interpretación de propiedades geotécnicas
Authors: Vásquez Artunduaga Faiver Atemo
Published: March 2019

La zonificación geotécnica previa del área urbana del Municipio de Neiva comprendida en la meta IV del proyecto "Microzonificación Sísmica de Neiva" (MSN), tiene como objetivo identificar zonas de similitudes geotécnicas para determinar zonas de alto riesgo previendo un eventual sismo que se presente; la cual se realizara mediante la recopilación de estudios de suelos, el análisis de propiedades índice geotécnicas como del geoprocesamiento de dichas propiedades y la elaboración de cartografía correspondiente a la zonificacion previa.

Bajo este objetivo se desarrolló el presente proyecto "Sistematización e Interpretación de Propiedades Geotécnicas", ejecutado en el Departamento Administrativo de Planeacion Municipal de la alcaldía de Neiva; cual se centro en la sistematización de la información existente de los resultados de estudios de suelos realizados en el área Urbana de Neiva, seguido de un análisis detallados de las propiedades geomecánicas, actividades las cuales fueron la base para la realización de la zonificacion geotécnica preliminar y de esta forma se dio cumplimiento a la ejecución de la meta IV del proyecto "MSN ".

Los resultados de estas investigaciones constituyen el soporte técnico-científico para la definición de nuevos sitios de exploración geotécnica profunda, en áreas sin información o de ¡nterás geológico-geotécnico, el análisis de laboratorio de parámetros físicos, mecánicos de los suelos incluyendo propiedades dinámicas y la instalación de la Red de Acelcrógrafos de Neiva, previstas en las metas VI y Vil de la MSN.
Labour Relations and the 1990’s Employment Regimes in Canada and Brazil
Authors: Costa Marcia
Published: March 2019

In an environment of global economic competition, corporations and the state have focused their strategies of competitive adjustment on labour flexibility and deregulation and reductions in social expenditures. In many countries, these policies led to the abandonment of full employment and increases in precarious or non-regulated employment. This article analyzes the main political and institutional elements of labour within Canada and Brazil, as well as recent changes in their employment regimes and labour market structures. Key research findings show us that greater labour market flexibility in both countries resulted in a reduction of labour rights that has contributed to the precariousness of work, increasing inequality in Canada, and higher levels of underemployment and poverty in Brazil.
CUPE’s Sympathy Strikes in British Columbia, October 2005: Raising the Bar for Solidarity
Authors: Camfield David
Published: March 2019

From October 7-23, 2005, the strike by the 38,000-strong British Columbia Teachers’ Federation (BCTF) was the “main event” in BC labour relations. Teachers demonstrated enormous solidarity and determination to achieve a fair negotiated settlement that they could put to a vote. The focus of this paper is not the BCTF strike itself but the remarkable sympathy strike action organized in support of BCTF, primarily by the BC division of CUPE. Such worker action is highly unusual. Since the 1940s sympathy strike action has been illegal and extremely rare. This paper sets CUPE-BC’s strikes in support of BCTF in the context of the legal framework established over half a century ago and the decline of sympathy strikes that followed. It then summarizes the events of October 2005 and examines the effects and significance of the strikes and what made them possible. It concludes with a reflection on the implications of these events for the labour movement. The analysis here is shaped by the perspective that public sector unions are best able to resist hostile governments when they adopt a militant and highly democratic approach that aims to build a broad social movement, sometimes referred to as social movement unionism.
CUPE on Strike, 1963-2004
Authors: Briskin Linda
Published: March 2019

CUPE On Strike offers a profile of the 1502 CUPE strikes since the union's inception in 1963 until 2004. In addition to breakdowns by province and industry, it considers strike incidence over time, duration, size of strikes, contract status, results, and the pattern of lockouts and rotating strikes. Like the overall Canadian strike profile, a majority of strikes are in small workplaces and are settled relatively quickly. Not surprisingly, CUPE strikes are clustered in Public Administration, and Health Care and Social Assistance. This demographic might help to explain the fact that CUPE has been involved in fewer wildcats, lockouts and strikes for first contracts than other unions. Although the overall trend for Canada since the 1990s has been a decrease in strikes, a modest shift in the last five years is evident in the data. For CUPE, this means more workers on strike, longer strikes, and more lockouts, all of which suggest an escalation in employer aggression. The Canadian data which highlight increasing public sector militancy and the feminization of that militancy suggest that CUPE will be a key player in the map of labour militancy in the future. This profile of the strike activities of CUPE, the largest union in Canada, makes visible the experience of strikes from the point of view of workers and their unions. Not only does it contribute to a labour militancy perspective on the quantitative data on work stoppages from Human Resources and Social Development Canada (HRSDC), it also demonstrates the potential of the data to enrich our understanding of worker militancies.
'I Need People That Are Happy, Always Smiling': Guest Interaction and Emotional Labour in a Canadian Downtown Hotel
Authors: Watt Paul
Published: March 2019

This paper discusses interactive service employment within the hospitality industry. Using research undertaken at a downtown hotel in a Canadian city, the paper examines front-line customer service workers engaged in guest interaction. It employs the concept of 'emotional labour', as developed by Hochschild, to illuminate not only managerial discourses, but also the work experiences of those women employed at the front desk (reception) and reservations. The women are shown to engage in intense and prolonged emotional labour, including having to routinely deal with 'irate guests'. The front office workers are shown to engage in covert resistance strategies in order to help them cope with the demands of the job including from aggressive guests. The paper also discusses the way that the work of women room attendants involved a guest interaction element, one that could involve doing emotional labour. The paper concludes by suggesting policy and further research implications, including on what the long-term effects of emotional labour might be.