bluuebunny/crossref_metadata_2025 huggingface dataset:
Sleep and diurnal alternative polyadenylation sites associated with human APA-linked brain disorders
Authors: Flores Carlos C. , Pasetto Nickolas A. , Wang Hongyang , Dimitrov Alexander G. , Davis Jon F. , Jiang Zhihua , Davis Christopher J. , Gerstner Jason R.
Published: August 2024

Disruption of sleep and circadian rhythms are a comorbid feature of many pathologies, and can negatively influence many health conditions, including neurodegenerative disease, metabolic illness, cancer, and various neurological disorders. Genetic association studies linking sleep and circadian disturbances with disease susceptibility have mainly focused on changes in gene expression due to mutations, such as single-nucleotide polymorphisms. The interaction between sleep and/or circadian rhythms with the use of Alternative Polyadenylation (APA) has been largely undescribed, particularly in the context of other disorders. APA is a process that generates various transcript isoforms of the same gene affecting its mRNA translation, stability, localization, and subsequent function. Here we identified unique APAs expressed in rat brain over time-of-day, immediately following sleep deprivation, and the subsequent recovery period. From these data, we performed a secondary analysis of these sleep- or time-of-day associated PASs with recently described APA-linked human brain disorder susceptibility genes.
Epidemiology and Risk Factors Predicting Mortality in Neonates with Meconium Aspiration Syndrome: A Multicentre Retrospective Study.
Authors: Singh Radhika , Jeena Prakash M , Tinarwo Partson , Adhikari Miriam
Published: August 2024

Background
Meconium aspiration syndrome (MAS) is a significant cause of mortality and morbidity in term and post-term neonates born through meconium-stained amniotic fluid (MSAF). Numerous antenatal and intrapartum risk factors are associated with mortality, and it is crucial for obstetricians to avoid these risk factors and for neonatologists to institute adequate therapy to improve outcomes.
Aim
To determine the predictors of mortality in neonates with meconium aspiration syndrome
Methods
This retrospective study reviewed data from four regional hospitals over three years from 01 January 2015 to 31 December 2017. During the study period, data were recorded with regard to sex, mode of delivery, gestational age, maternal age, asphyxia, Apgar score at one and five minutes, persistent pulmonary hypertension, and respiratory support of neonates with MAS.
Results
Of the 187 neonates identified with MAS, 30 died, with a case fatality rate of 16%. Ninety-seven (51.9%) neonates were diagnosed with asphyxia, 91 (48.7%) with seizures, and 55 (27.3%) with PPHN. The factors associated with mortality were male sex (p = 0.009), a low Apgar (< 7 at five minutes) (p = 0.003), asphyxia (p ≤ 0.001), any form of resuscitation (p = 0.003 and < 0.001), bag-mask ventilation (BMV) and cardiac massage, respectively, and the presence of PPHN (p = 0.007) and air leakage (p = 0.002). After adjusting for all variables, the presence of asphyxia and air leakage were significantly associated with mortality, with ORs of 39.79 (3.93–1151) and 79.46 (3.53–2985), respectively.
Conclusion
Meconium aspiration syndrome is a significant cause of mortality. Asphyxia and air leakage are significant contributors to mortality in neonates with MAS. Continuous fetal monitoring, early recognition of fetal distress, and timely intervention during the intrapartum period are crucial for preventing asphyxia. Postnatally, neonates with MAS should be managed appropriately to prevent PPHN and air leakage, and seizures should be well controlled.
MyoRegenTrack: Quantifying the Recovery Process of Skeletal Muscle on HE-Stained Images via Learning from Label Proportion
Authors: Yamaoka Yu , Seno Shigeto , Chan Weng Ian , Iwamori Kanako , Fukada Soichiro , Matsuda Hideo
Published: August 2024

Visual observing muscle tissue regeneration is used to measure experimental effect size in biological research to discover the mechanism of muscle strength decline due to illness or aging. Quantitative computer imaging analysis for support evaluating the recovery stage has not been established because of the localized nature of recovery and the difficulty in selecting image features for cells in recovery stages. We constructed MyoRegenTrack for segmenting cells and classifying their regeneration stage in hematoxylin-eosin (HE) stained images. A straightforward approach to classification is supervised learning. However, obtaining detailed annotations for each fiber in a whole slide image is impractical regarding cost and accuracy. Thus, we propose to learn individual fiber stage classification utilizing the proportions of fiber stages depending on the days after muscle injection to induce regeneration. We extract implicit multidimensional features from the HE-stained tissue images and train a classifier using weakly supervised learning, guided by their class proportion for elapsed time on recovery. We confirmed the effectiveness of MyoRegenTrack by comparing its results with expert annotations. A comparative study of the recovery relation between two different muscle injections shows that the analysis result using MyoRegenTrack is consistent with findings from previous studies.
ART: An Efficient Framework for Automated Regression Testing for C/C++ Projects
Authors: Do Minh-Hieu , Tran Hoang-Viet , Pham-Ngoc Hung
Published: August 2024

Regression testing, a critical phase in a software life cycle, often incurs significant time and cost for software companies, underscoring the need for an effective automated regression testing method. This paper introduces an efficient framework, ART, designed for automated regression testing of C/C++ projects. The fundamental concept of ART is to employ the Concolic testing method for comprehensive automated test generation for the initial version of a software product. Upon testing the updated version of the software, ART identifies all modifications in the new version. Subsequently, ART utilizes a change impact analysis (CIA) method, Wave-CIA, to determine the impact set of components in the updated software version. Ultimately, ART applies the Concolic testing method exclusively to the modified and impacted components. As a result, ART significantly reduces the time and cost associated with regression testing of the updated version. Preliminary experimental results indicate that ART can reduce the required testing time for the new version of a software product by up to 92%. Further discussions regarding the ART framework are provided in the paper.
How Does Self-esteem Alleviate Death Anxiety in Youth Populations? The Mediating Role of Security
Authors: Yu Jingxian , Hu Ziping , Liang Yongqi , Peng Huan , Li Na , Liu Hanjiao
Published: August 2024

With the widespread use of the Internet and social media, youth groups are suffering deaths with increasing frequency. Studies have shown that self-esteem and a sense of security can reduce death anxiety, but a detailed explanation of the relationship is still lacking. Therefore, this study aimed to explore the interrelationship and potential pathways of death anxiety, self-esteem, and security in young people. A cross-sectional study was conducted in Shenzhen and Shaoguan, Guangdong Province, China, to collect general data, death anxiety scores, self-esteem scores, and security scores. A total of 623 valid questionnaires were collected from November to May 20232024. The results showed that both self-esteem and a sense of security could significantly predict death anxiety in reverse. Moreover, the sense of security engagement mediated the relationship between self-esteem and death anxiety. Although there is a high level of death anxiety in young people, measures to enhance self-esteem and a sense of security can help alleviate anxiety and promote physical and mental health.
Protective Effect of Apelin-13 on D-Glutamic Acid-Induced Excitotoxicity in SH-SY5Y Cell Line: An In-Vitro Study
Authors: Oruç Kadriye Yağmur , Oruç Aykut , Ağtürk Gökhan , Yanar Karolin , Seymen Hakkı Oktay
Published: August 2024

Excitotoxicity, resulting from excessive accumulation of glutamate in the extracellular space, leads to neuronal cell death. This study investigates the protective effects of Apelin-13 on D-glutamic acid-induced excitotoxicity in SH-SY5Y human neuroblastoma cells, an in vitro model for neurodegenerative diseases. Unlike the commonly studied L-glutamic acid, this research focuses on D-glutamic acid to understand its specific impacts. SH-SY5Y cells were treated with varying concentrations of D-glutamic acid and Apelin-13, followed by analyses at 12 and 24 hours to evaluate cell viability, oxidative stress markers, and inflammatory cytokine levels. Cell viability assays revealed significant cytotoxic effects of D-glutamic acid at doses of 10 mM and 20 mM, reducing viability by over 50%. However, Apelin-13 treatment mitigated these effects, especially at 2 µg/mL, enhancing cell viability and reducing inflammatory cytokine levels (IL-1β and TNF-α). Apelin-13 also increased anti-inflammatory cytokine levels (IL-10 and TGF-β1) and brain-derived neurotrophic factor (BDNF), indicating its neuroprotective role. Oxidative stress markers, including ROS, AGE, AOPP, DT, and T-SH, were significantly elevated by D-glutamic acid but effectively reduced by Apelin-13. The neuroprotective mechanisms of Apelin-13 involve modulation of cAMP/PKA and MAPK signaling pathways, enhancing BDNF synthesis and suppressing oxidative stress and inflammatory responses. This study is the first to demonstrate the effects of D-glutamic acid on SH-SY5Y cells. It highlights Apelin-13’s potential as a therapeutic agent against excitotoxicity-induced neuronal damage, emphasizing its ability to modulate key molecular pathways involved in inflammation and oxidative stress. Further in vivo studies are warranted to explore the long-term neuroprotective effects of Apelin-13 in treating neurodegenerative diseases.
Intraoperative dysglycemia among nondiabetic patients undergoing surgeries: A prospective study in the Palestinian hospitals
Authors: Gara Hiba , Natour Adan , Hugi Samah , Jaber Mohammad , Maqboul Iyad , Khelfeh Nashat , Houmran Diaa , Kanaan Mohammad , Ghanem Nadeen , Ibrahim Leen , AbuAlrub Ibraheem , Sawafta Nawras , Hamed Alaa , Shawahna Ramzi
Published: August 2024

Background
Intraoperative dysglycemia is a common health issue among surgical patients in different healthcare systems around the world. This prospective study was conducted to assess the incidence of intraoperative dysglycemia among patients undergoing surgeries in the Palestinian practice.
Methods
This was a prospective study that was conducted in the period between 29th October 2023 until 1st January 2024. The demographics, clinical, and surgical characteristics of the patients were obtained using a standardized data collection form. Capillary blood glucose levels were measured preoperatively, before the induction of anesthesia, after the induction of anesthesia, during surgery, and after surgery.
Result
A total of 374 patients were included in this study. Of the patients, 211 (56.4%) were younger than 35 years, 205 (54.8%) were females, and 256 (68.4%) were either overweight or obese. Obstetrics and gynecological, abdominal, and orthopedic surgeries were the most common surgeries in this study. The majority of the patients (69.3%) received general anesthesia. The delta change in blood glucose after induction of anesthesia was significantly higher among the patients were never married (p = 0.021), were operated for 1 h or more (p = 0.024), received general anesthesia (p = 0.001), did not experience heart rate changes (p = 0.004), and received steroid (p = 0.050). The delta change in blood glucose during surgery was significantly higher among the patients who received intraoperative dextrose (p < 0.001) and were operated for 1 h or more (p = 0.020). Similarly, the delta change in blood glucose after surgery was significantly higher among the patients who received intraoperative dextrose (p < 0.001), crystalloid (p = 0.045), blood transfusion (p = 0.010), were operated for 1 h or more (p = 0.005), received general anesthesia (p = 0.014), experience heart rate changes (p = 0.015), and received steroid (p = 0.002).
Conclusion
Intraoperative dysglycemia occurred among patients who underwent surgeries in the Palestinian practice. This intraoperative dysglycemia was associated with certain demographic and surgical variables. Anesthesiologists, surgeons, and providers of perioperative care services should consider monitoring blood glucose levels preoperatively, intraoperatively, and postoperatively.
Dynamic modelling and performance analysis of deployable Telescopic Tubular Mast
Authors: Sun Tongtong , Gasbarri Paolo , Du Lin , Deng Zichen
Published: August 2024

This work presents the longitudinal and transverse coupling vibrations of a deployable Telescopic Tubular Mast (TTM), a multi-stepped structure integrated into a spacecraft system, while considering the rigid-flexible coupling phenomenon. The model is derived using the principle of virtual work and discretized via the variable separation method. The von Kármán strain is employed to incorporate geometric nonlinear effects. Semi-analytical results for the shape functions and natural frequencies of the quasi-static multi-stepped boom are obtained using the extended transfer matrix method (ETMM). These natural frequencies are validated against results from Nastran, confirming the ETMM's accuracy Additionally, the model accounts for the continuously changing natural frequencies and shape functions during the deployment phase. Finally, the dynamic phenomena of the longitudinal and transverse displacements are analyzed at various deploying states, including locking and restart behaviors. The influence of the structural damping on the vibration evolution is also contained in the numerical analysis.
Copper catalyzed carbon-selenium bond formation via the coupling reaction of aryl halides, phenylboronic acid and Se
Authors: Shirvandi Zeinab , Ghorashi Nadya , Rostami Amin
Published: August 2024

This is the first report for C-Se bond formation involving the reaction of aryl halides with arylboronic acid and selenium powder to synthesis of unsymmetrical diaryl selenides in the presence of CuI as a homogeneous catalyst. A wide range of aryl halides react with various substituted groups under optimal conditions to provide the desired unsymmetrical diaryl selenides with good to high yields. Also, the same reactions were investigated in the presence of M-MCF@Gua-Cu as a reusable magnetic nanocatalyst under optimal conditions. The M-MCF@Gua-Cu catalyst allows for simpler (easy work-up) and greener methodology. In addition, the advantages of the presented method include the use of arylboronic acid/Se as a safe and cost-effective arylselenating system, the simplicity of operation, and green and cheap solvent.
Who needs an endometrial biopsy when cervical cytology finds endometrial cells?
Authors: Xie Xiaoping , Fan Xiaoli , Ding Yulin , Zhang Xiaorong , Jiang Yuxia
Published: August 2024

Background Previous studies have suggested that non-menstrual cervical cytology findings of endometrial cells may indicate endometrial lesions. However, no clear guidelines recommend who should undergo endometrial biopsy. This study aimed to identify which patients should undergo endometrial biopsy among those whose cervical cytology showed endometrial cells.
Methods We retrospectively analyzed 173 patients with cervical cytology to find endometrial cells in our department. Hysteroscopic diagnostic curettage obtained histological evidence in all patients.
Results From January 1, 2020, to October 27, 2023, 173 patients underwent hysteroscopic surgery in our department due to endometrial cells found in cervical cytology. Five patients (2.89%) had endometrioid carcinoma, and two patients (1.16%) had endometrial atypical hyperplasia. All 7 had abnormal uterine bleeding/postmenopausal bleeding. Endometrial thickness was 22.9 mm and 20.9 mm in 2 premenopausal patients, median endometrial thickness was 34 mm (8.2-41.4mm) in 5 postmenopausal patients, and heterogeneous endometrial echo in 7 patients. There were 54 patients without abnormal uterine bleeding/postmenopausal bleeding, endometrial thickening, and endometrial echo homogeneity. None of them had endometrial atypical hyperplasia/endometrial cancer. Univariate and multivariate logistic regression analysis showed that diabetes and endometrial thickening were independent risk factors for endometrial atypical hyperplasia/endometrial cancer.
Conclusions Patients with endometrial atypical hyperplasia/endometrial cancer often have abnormal bleeding and thickening of the endometrium. If the patient's cervical cytology shows endometrial cells without abnormal bleeding and endometrial thickening, the probability of endometrial atypical hyperplasia/endometrial cancer is minimal. Univariate and multifactorial logistic regression analysis showed that diabetes and endometrial thickening were independent risk factors for endometrial atypical hyperplasia/endometrial cancer.
Automated environmental metagenomics using Oxford Nanopore sequencing
Authors: Child Harry T. , Wierzbicki Lucy , Joslin Gabrielle R. , Rober Katherine , Haxhiraj Qiellor , Tennant Richard K.
Published: August 2024

Long-read sequencing has revolutionised metagenomics through improved metagenome assembly, taxonomic classification and functional characterisation. Automation can enhance the throughput, reproducibility, and accuracy of library preparation. However, the validation of automated library preparation protocols remains undetermined for metagenomic workflows, which are particularly sensitive to methodological perturbation. Here, we compare long-read metagenomic sequencing of environmental samples through parallel manual and automated protocols. Despite minor variation in read lengths and classification rate, minimal differences in microbial community structure were identified between manual and automated libraries. These findings demonstrate the utility of automation for high-throughput long-read metagenomics, with broad applicability to automated long-read sequencing.
BLCD: A Balanced and Low-Power Cell Design Family for Secure Applications
Authors: Shirmohammadi Alireza , Naji Hamid Reza
Published: August 2024

Providing a secure hardware infrastructure is the main issue to implement secure cryptographic algorithms.
Just a robust algorithm with suitable key lengths is not effective against differential analysis attacks and can cause the cryptographic key to be discovered. Today, credit cards and electronic identification cards, due to the greater scope of applications are subjected to differential power analysis (DPA) attacks. As a result, a good design can help maintain the confidentiality of information. Providing a design method that balances the power consumption of the outputs and inputs of chips results a DPA secure designs. Moreover, reduction of power consumption by recovering the charge stored in nodes can make the tracing power will be more difficult. On the other hand, designing a uniform pattern in the transistor surface shape for all logic gates will make them resilient against advanced imaging techniques. In this paper a DPA resilient design method is proposed which is also robust against some other attacks such as timing attacks and advanced image processing techniques. The presented designs are simulated and compared with the state of the art designs using Synopsis HSPICE with 22nm technology node. Simulation results shows that the proposed method has the lowest and most balanced power consumption compared to the other designs.
Depression and associated factors among people with epilepsy at Wolaita Sodo University Hospital, South Ethiopia
Authors: Berhanu Tamene , Yigzaw Niguse , Tinsae Seblewongel , Mirkena Yohannes , Belete Asegid
Published: August 2024

Background
Epilepsy is the most common neurological disorder in the world and contributed to various psychiatric illnesses. Depression is one of the most frequent co morbid psychiatric disorders that affect the quality of life in patients with epilepsy. Despite this impact depression continues to be under-recognized and undertreated. Therefore this study amid to assess the magnitude of depression and its associated factors among patients with epilepsy at Wolaita sodo university hospital, South Ethiopia 2021.
Methods
A hospital based cross sectional study was conducted from April 2021-May 2021. A systematic random sampling technique was used to select 423 samples of patients with epilepsy and interviewer administrated structured questionnaires was employed. Patient Health Questionnaire with 9-items was used to assess depression. Logistic regression model was used to determine the association between the outcome and independent variables. A 95% CI and Odds ratio with corresponding p-value < 0.05 were used to determine the strength of association.
Result
The overall magnitude of depression among epileptic patients in this study was 49.2%. Educational status; unable to read and write (AOR = 3.43, 95%CI:1.09,10.7), being female (AOR = 2.54, 95%CI:1.43,4.52), perceived stigma (AOR = 5.96, 95%CI:2.88,12.3), poor social support (AOR = 2.88, 95%CI:1.28, 6.48), poor medication adherence (AOR = 4.60, 95%CI: 2.46,8.63), seizure frequency of 6 times per month (AOR = 5.59, 95%CI:1.72, 18.1) were independent predictors of depression among patients with epilepsy at p-value < 0.05.
Conclusion and recommendation:
In this study nearly half of the patient with epilepsy had depression. Educational status; unable to read and write, being female, perceived stigma, poor social support, poor medication adherence, seizure frequency of 6 times per month were independent predictors of depression among patients with epilepsy. Therefore screening depression in epileptic patients and appropriate management critically needed attention to reduce the effects of the problems.
From Butterfly Wings to Sectoral Clusters: Unveiling the Anatomy and the Dynamic of the Moroccan Production Network
Authors: Elguellab Ali , Ezzahid Elhadj
Published: August 2024

The analysis of production networks plays a crucial role in understanding the economic landscape and addressing development issues. This paper applies network theory to analyze the Moroccan production network, examining its holistic structure, industries and cluster. It uses national accounting data and OECD datasets from 66 countries. Our investigation reveals a "butterfly" structure, with upstream and downstream sectors connected by a middle core of highly connected sectors. The network exhibits lower density compared to other countries, raising questions about growth and efficiency. Our analysis underscores the need for policies that foster domestic input production and reduce import dependence. Moreover, it emphasizes the importance of providing a more granular and frequent input-output table to inform more nuanced insights.
Conditions of Forming the Experience of Social Behavior Among Junior School Students in Class of the Course «Talking about Important»
Authors:   Irkutsk State University, Kalinina Larisa V.
Published: August 2024

The article presents an analysis of studies on the formation of the experience of social behavior among junior school students, the preparation of teachers for the organization of this process. The purpose of the study is to determine the conditions of forming the experience of social behavior in primary general education. Such research methods as terminological and comparative analysis of scientific literature, generalization and synthesis of the studied materials, study and analysis of methodological literature, designing methods of pedagogical activity were used. The article notes that the experience of social behavior is positioned as an important personal education with the introduction of the updated Federal State Standard of Primary General Education; its study is not sufficiently reflected in the scientific and pedagogical literature. The study presents a description of the concept of «experience of social behavior»: its features are highlighted, the components are revealed in a meaningful way. The position of the author is indicated, in which, in the formation of the experience of social behavior of junior school students, the priority role is given to the personality of the teacher. The personal and professional components of readiness for the implementation of this pedagogical activity are revealed. The position has put forward and substantiated that the content of the extracurricular activity course «Razgovory o vazhnom» contributes to the formation of the experience of social behavior. However, elementary school teachers find it difficult to design ways to form the entire set of its components. The possibilities of the content of classes have been studied on the example of the topic «We are different, we are together». Methods for adjusting classes, taking into account the formation of the experience of social actions, are proposed. The conducted research confirms the need to comprehend the theoretical foundations and ways of practical solutions related to the social behavior of junior school students, which requires the improvement of methods of pedagogical activity.
Human Rights Education in Indonesia: History, Problems, Prospects
Authors:   University of Surabaya, Vira Herawati Aloysia , Ermakov Dmitry S. ,   Peoples’ Friendship University of Russia named after Patrice Lumumba
Published: August 2024

Like education for sustainable development, human rights education is one of the strategic directions of modern education, acting as one of the leading mechanisms for solving socio-ecological and economic problems at the global, national, regional, institutional and individual levels. The article reveals the historical background of human rights education, shows its importance both in general and, in particular, for the Republic of Indonesia, one of the largest countries in the world and Southeast Asia. The study of human rights in Indonesia is presented in the context of the formation and development of statehood and the education system since prehistoric times, during the colonial era, the period of growth of national consciousness, the military regime and modern democratic reforms. The pedagogical features of the implementation of the National Human Rights Action Plan (from 2004 to the present) are characterized. A number of educational programs (2013 program, emergency program, Merdeka program) and courses (“Civic Education”, “Religion”, “Geography”, “Social Studies”, “Citizenship”, “Citizenship and Human Rights”, “Human Rights”, etc.) are presented, as well as pedagogical technologies, methods and techniques used in the process of their implementation in secondary schools and universities. A number of problems related to the traditions of the national education system have been identified, and possible solutions have been proposed. In general, it seems advisable to integrate education for sustainable development and in the field of human rights, which will lead to a synergistic effect that increases mutual effectiveness in the realization of the universal right of every human being – the right to development.
The Huanglongbing-associated Preharvest Fruit Drop Signal Arises Several Weeks Before the Physical Separation of Sweet Orange Fruit
Authors: Singh Sukhdeep , Sutton Mary , Guha Anirban , Alferez Fernando , Vincent Christopher , Vashisth Tripti
Published: August 2024

The spread of Huanglongbing (HLB), a bacterial disease presumed to be caused by Candidatus Liberibacter asiaticus, throughout the state of Florida has coincided with a steady decline in total citrus (Citrus sp.) production. This decline is partially attributable to the high rates of preharvest fruit drop seen in HLB-affected trees. Although mature fruit drop is a natural phenomenon, the drop rates continue to increase as HLB symptom severity worsens. Unfortunately, how HLB causes this increase in fruit drop remains unknown. The current study aimed to determine the fruit characteristics associated with mature fruit drop in sweet orange (Citrus ×sinensis) and to provide an understanding of the possible role of endogenous ethylene, carbohydrates, and water deficit in HLB-associated preharvest fruit drop. Therefore, preharvest fruit drop rates of ‘Hamlin’ and ‘Valencia’ trees exhibiting mild, moderate, or severe HLB symptoms were monitored during the preharvest period (October–December for ‘Hamlin’ and January–May for ‘Valencia’). In addition, a subset of 20 fruit was collected to measure the fruit detachment force (FDF), which is the amount of force necessary to detach the fruit from the stem. After performing FDF measurements, eight additional physical and biochemical variables of tight and loose fruit (categorized by FDF) were measured. The total fruit drop rate during the preharvest period was higher for trees with severe visual HLB symptoms than for mild trees. Similarly, this increase in drop rates was negatively correlated with the canopy density. The fruit from severe trees (with high preharvest drop) showed increases in gene activity related to ethylene and abscisic acid earlier in the preharvest drop season, but not late in the season. No consistent carbohydrate pattern in tight and loose fruit was observed. Fruit likely to drop (those with lower FDF) were also consistently smaller than the fruit likely to be maintained on the tree (those with higher FDF). Therefore, it is proposed that the suppression of fruit growth early in the developmental period (possibly caused by water deficit) determines the fate (to drop or not) of the fruit before they have reached physiological maturity. Thus, strategies to mitigate preharvest fruit drop should be applied earlier in the season, and possibly during early stages of fruit development. By the time actual fruit drop becomes evident, the fruit drop-related signals have already been triggered, and treatments may not effectively reduce drop.
Evaluating the Efficacy of a Haemophilus Somnus Bacterin in a Controlled Field Trial
Authors: Morter R. L. , Amstutz H. E.
Published: August 2024

A controlled field trial was designed to evaluate the efficacy of Somnugen in reducing the incidence and severity of BRD in feedlot cattle.  Submitted as Journal Paper No. 9531, Purdue Agricultural Experiment Station, West Lafayette, Indiana 47907
Bovine Practitioner Vol. 41, No. 2 (2007 Summer). Front matter
Authors: American Association of Bovine Practione
Published: August 2024

Cover, masthead, table of contents, and other editorial information.
Index of Publications. The Bovine Practitioner 1989-1994 / Proceedings of the Annual Meetings 1989-1994
Authors: Bovine Practitioners American Association of
Published: August 2024

Author and subject indexes for the Bovine Practitioner and the Proceedings of the Annual Meetings, 1989-1994.
Bovine Practitioner No. 32.1 (1998 January). Front matter
Authors: American Association of Bovine Practitioners
Published: August 2024

Cover, masthead, table of contents, and other editorial information.
Bovine Practitioner Vol. 33, No. 1 (1999 January). Front matter
Authors: American Association of Bovine Practitioners
Published: August 2024

Cover, masthead, table of contents, and other editorial information.
Bovine Practitioner Vol. 36, No. 1 (2002 February). Front matter
Authors: American Association of Bovine Practitioners
Published: August 2024

Cover, masthead, table of contents, and other editorial information.
American Association of Bovine Practitioners 36th Annual Conference (2003): Part 1
Authors: Bovine Practitioners American Association of
Published: August 2024

Description and highlights of the 36th Annual Convention American Association of Bovine Practitioners (2003), information about, events, awards, receptions, etc.
Bovine Practitioner No. 7 (1972 November). Front matter
Authors: American Association of Bovine Practitioners
Published: August 2024

Cover, masthead, table of contents, and other editorial information.
Medicinal Plants Antifungal Agents Against Pathogenic Dermatophytes and Phenol Content Measurement
Authors: Ranjbar Zahra , Ayatollahi Mousavi Seyyed Amin , Aghaei Afshar Abbas , Madani Mahboobeh , Shakib Pegah
Published: August 2024

Introduction:

Dermatophytes are a class of fungi that invade keratinized tissues
in humans and other animals, including hair, skin, and nails, causing dermatophytoses. The
high cost of therapy, side effects of drugs, and occasionally microbial resistance to synthetic
drugs are some of the issues that have prompted efforts to find new medicines. This research
aimed to study the antifungal properties of ethanolic and methanolic extracts of Rumex
acetosella, Teucrium polium, and Glycyrrhiza glabra plants against Microsporum canis,
Microsporum gypseum, and Trichophyton mentagrophytes and to ascertain the phenol content of
these plants.

Methods:

Following the collection and identification of R. acetosella, T. polium, and G. glabra
for this descriptive comparative study, they were washed and dried in the shade. Next, the Soxhlet
apparatus was used to obtain methanolic and ethanolic extracts from these plants. The antifungal
activity of these extracts was examined in vitro against M. canis, M. gypseum, and T. mentagrophytes
using the diffusion and agar dilution method according to CLSI guidelines. The Minimum
Inhibitory Concentration [MIC] and the Minimum Fungicidal Concentration [MFC] of the
extracts were also determined compared to griseofulvin. Additionally, the phenol content of these
extracts was measured by an optical spectrophotometer.

Results:

The methanolic extract of T. polium at 200 mg/ml led to the maximum inhibition zones
of T. mentagrophytes PTCC 5054, M. canis PTCC 5069, and M. gypseum PTCC 5070 that were
23.41, 23.45, and 25.30 mm, respectively. The highest growth rates of T. mentagrophytes, M. canis,
and M. gypseum in agar dilution method were found in 2.5 mg/ml of G. glabra ethanolic extract
at 19.07, 18.32, and 17.81 mm, respectively. The smallest growth of T. mentagrophytes, M.
canis, and M. gypseum were observed in the plate containing 40 mg/ml of the methanolic extract
of T. polium, with 5.62, 3.72, and 5.41 mm diameters, respectively. MIC was less than 6.25
mg/ml for methanolic extract of T. polium. The tannic acid in the ethanolic and methanolic extracts
of T. polium, R. acetosella, and G. glabra were 227.33 and 482.89 μg/ml, 94 and 475.48
μg/ml, and 27.33 and 60.67 μg/ml, respectively.

Conclusion:

The results revealed that methanolic extracts of the plants under study, particularly
T. polium, had a stronger inhibitory impact than ethanolic extracts. Following rigorous toxicity
testing and in vivo research, methanolic extracts of these plants may prove to be effective options
as adjuvants or alternatives to chemical drugs.
Social Determinants of Health Phenotypes and Cardiometabolic Condition Prevalence Among Patients in a Large Academic Health System: Latent Class Analysis
Authors: Howell Carrie R , Zhang Li , Clay Olivio J , Dutton Gareth , Horton Trudi , Mugavero Michael J , Cherrington Andrea L
Published: August 2024

Background

Adverse social determinants of health (SDoH) have been associated with cardiometabolic disease; however, disparities in cardiometabolic outcomes are rarely the result of a single risk factor.

Objective

This study aimed to identify and characterize SDoH phenotypes based on patient-reported and neighborhood-level data from the institutional electronic medical record and evaluate the prevalence of diabetes, obesity, and other cardiometabolic diseases by phenotype status.

Methods

Patient-reported SDoH were collected (January to December 2020) and neighborhood-level social vulnerability, neighborhood socioeconomic status, and rurality were linked via census tract to geocoded patient addresses. Diabetes status was coded in the electronic medical record using International Classification of Diseases codes; obesity was defined using measured BMI ≥30 kg/m2. Latent class analysis was used to identify clusters of SDoH (eg, phenotypes); we then examined differences in the prevalence of cardiometabolic conditions based on phenotype status using prevalence ratios (PRs).

Results

Complete data were available for analysis for 2380 patients (mean age 53, SD 16 years; n=1405, 59% female; n=1198, 50% non-White). Roughly 8% (n=179) reported housing insecurity, 30% (n=710) reported resource needs (food, health care, or utilities), and 49% (n=1158) lived in a high-vulnerability census tract. We identified 3 patient SDoH phenotypes: (1) high social risk, defined largely by self-reported SDoH (n=217, 9%); (2) adverse neighborhood SDoH (n=1353, 56%), defined largely by adverse neighborhood-level measures; and (3) low social risk (n=810, 34%), defined as low individual- and neighborhood-level risks. Patients with an adverse neighborhood SDoH phenotype had higher prevalence of diagnosed type 2 diabetes (PR 1.19, 95% CI 1.06‐1.33), hypertension (PR 1.14, 95% CI 1.02‐1.27), peripheral vascular disease (PR 1.46, 95% CI 1.09‐1.97), and heart failure (PR 1.46, 95% CI 1.20‐1.79).

Conclusions

Patients with the adverse neighborhood SDoH phenotype had higher prevalence of poor cardiometabolic conditions compared to phenotypes determined by individual-level characteristics, suggesting that neighborhood environment plays a role, even if individual measures of socioeconomic status are not suboptimal.
Characterization of Psychopathology in Latin American Adolescents Using a Web-Based Screening Tool: Cross-Sectional Study
Authors: Campos Susana , Nuñez Daniel , Pérez J Carola , Robinson Jo
Published: August 2024

Background

Mental health problems and suicide ideation are common in adolescents. Early detection of these issues could prevent the escalation of mental health–related symptoms in the long term. Moreover, characterizing different profiles of prevalent symptoms in conjunction with emotional regulation strategies could guide the design of specific interventions. The use of web-based screening (WBS) tools has been regarded as a suitable strategy to timely detect symptomatology while improving the appeal, cost, timeliness, and reach of detection in young populations. However, the evidence regarding the accuracy of these approaches is not fully conclusive.

Objective

The study aims (1) to examine the capability of a WBS to identify adolescents with psychiatric symptoms and suicidality and (2) to characterize the mental health profiles of a large sample of adolescents using WBS.

Methods

A total of 1599 Latin American Spanish-speaking adolescents (mean age 15.56, SD 1.34 years), consisting of 47.3% (n=753) female, 98.5% Chilean (n=1570), and 1.5% Venezuelan (n=24) participants, responded to a mental health WBS. A randomized subsample of participants also responded to the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID). McNemar χ2 and receiver-operating characteristic curves tested the detection accuracy of WBS contrasted with the MINI-KID. Latent profile analyses explored the symptomatic and emotional regulation profiles of participants.

Results

Both measures showed an adequate level of agreement (area under the curve per symptom domain ranging from 0.70 to 0.89); however, WBS yielded a higher prevalence than MINI-KID for all psychiatric symptoms, except suicide ideation and depression. Latent profile analyses yielded 4 profiles—one of them presented elevated psychopathological symptoms, constituting 11% of the sample (n=175). Rumination (odds ratio [OR] 130.15, 95% CI 51.75-439.89; P<.001), entrapment (OR 96.35, 95% CI 29.21-317.79; P<.001), and defeat (OR 156.79, 95% CI 50.45-487.23; P<.001) contributed significantly to the prediction of latent profile memberships, while cognitive reappraisal did not contribute to the prediction of any latent profile memberships, and expressive suppression was only associated to profile-2 membership.

Conclusions

WBS is acceptable for the timely detection of adolescents at risk of mental health conditions. Findings from the symptomatic and emotional regulation profiles highlight the need for comprehensive assessments and differential interventions.
Exploring the service users’ experiences of a community-based intervention to improve follow-up at Bharatpur Eye Hospital in Nepal: A Qualitative Study. (Preprint)
Authors: Shrestha Manisha , Bhandari Gopal , Bhandari Sadhan , Murthy Gudlavalleti Venkata Satyanarayana , Priya Ruchi , Pandey Binod , Chaudhary Daya Shankar , Shrestha Puspa Giri , Kamalakannan Sureshkumar ,   Operational Research Capacity Building Study Group
Published: August 2024

BACKGROUND

Follow-up to eye care services for children especially in the context of Nepal is essential for ensuring a continuum of care. Hence, as a continued effort, we designed this study to explore the service users’ experience of this community-based intervention to improve follow-up at Bharatpur Eye Hospital (BEH) in Nepal.

OBJECTIVE

This study aimed to explore the experiences and perceptions of service users about the community-based follow-up intervention for eye-care services implemented by BEH in Nepal.

METHODS

A qualitative study utilizing an in-depth interview approach was used. Participants were purposively selected for this research study. Participants who were part of a quasi-experimental study conducted to improve follow-up services in BEH and their service catchment area were chosen. Those participants who had not attended even a single follow-up visit and those who attended at least one follow-up were recruited for this qualitative study. Based on the distance from the base hospital and the follow-up status 65 participants were initially found eligible for the qualitative study. However, only 17 participants were available and consented. Topic guides were developed for the purpose of in-depth interviews specifically for participants, who had not attended even the first follow-up visits and those who attended at least one follow-up visit. Two ophthalmic assistants, who were not a part of the main intervention study, conducted the interviews.

RESULTS

Seventeen service users whose children were receiving services from BEH hospital participated in the qualitative study. We identified four key themes that provided invaluable information about the barriers and facilitators to follow-up as well as the experiences (positive/negative) of the participants that needs to be considered in any future initiatives to improve follow-up in Nepal.

CONCLUSIONS

It highlights the need for systematic development of interventions to address the unmet need for eye care services in the community through innovative scalable solutions. As a next step, the BEH team will be working to develop such scalable solutions for Nepal. Such interventions will also need to be optimized for similar settings and countries to meet the goals of universal health coverage, vision 2030 and sustainable development goals worldwide.
Peran Moderasi Beragama Untuk Pengembangan Sikap Nasionalisme Remaja Dalam Kerangka Ketahanan Sosial Di Lampung Tengah, Propinsi Lampung
Authors: Tumanggor Raja Oloan , Dariyo Agoes
Published: August 2024

ABSTRAKSikap nasionalisme merupakan sikap untuk mencintai tanah-air sebagai tempat tinggal selama hidupnya. Sikap nasionalisme sesungguhnya sebagai sikap yang mampu memahami dan menerima warga negara lain, meskipun mempunyai latar belakang yang berbeda, seperti perbedaan agama. Karena itu, penelitian ini hendak mengkaji mengenai peran moderasi beragama untuk mengembangkan sikap nasionalisme remaja dan implikasinya terhadap ketahanan sosial di Kabupaten Lampung Tengah, Propinsi Lampung. Teknik pengambilan sampling dengan Proportional Stratified Random Sampling. Teknik pengambilan data dengan menggunakan kuesioner yaitu moderasi beragama dan sikap nasionalisme. Partisipan penelitian berasal dari remaja usia 13-20 tahun berjumlah 146 orang. Teknik analisis data dengan uji korelasi produk moment dan regresi linear tunggal sederhana. Hasil penelitian ditemukan bahwa terdapat hubungan positif signifikan antara moderasi beragama dengan sikap nasionalisme remaja di Indonesia (r = 0, 501, p = 0,000, p < 0,01).  Selanjutnya, moderasi beragama menyumbang sikap nasionalisme sebesar 25 % terhadap  sikap nasionalisme remaja di Indonesia
Resultados preliminares del comportamiento de las líneas prohibidas de emisión del oxígeno neutro λ 5577 A y λ 6300 A del resplandor nocturno en El Cerrillo.
Authors: Báez A. P.
Published: August 2024

Se discuten en este trabajo los resultados preliminares de las observaciones de las emisiones de las líneas prohibidas del oxígeno neutro [OI] λ 5577 A λ 6300 A del resplandor nocturno llevadas a cabo en la estación de El Cerrillo, Edo. de México. Se cree que las observaciones en ese sitio pueden considerarse como parte de los fenómenos que ocurren en latitudes bajas.
The Development of Lecture Maker Applications in Arabic Language Learning for Elementary School
Authors: Widayanti Rizka , Mudinillah Adam , Amrina Amrina , Ramadhanti Febriani Suci , Yusuf Salam Muhammad , Rezi Melisa , Dewi Yelfi , Kddour Guettaoui Bedra
Published: August 2024

The research aimed to produce and develop a Lecture Maker-based learning media in Arabic subjects for Islamic elementary school students, which was in accordance with the eligibility criteria for learning media that was valid, practical and effective. The type of research used Research and Development (R&D). The research model used ADDIE (analysis, design, development, implementation, and evaluation). The results of the research that showed that, (1) the validation results obtained in the use of Lecture Maker-based learning media showed a value of 4.22 which included in the 'valid ' category. (2) Based on the average teacher response showed the number 4.6 this meant that the Lecture Maker-based learning media was 'very valid'. While the average percentage was 92.00% which indicated that the media produced could be said to be practical to use. (3) Based on the analysis of students' cognitive results, it could be seen that classical learning completeness reaches 87.5% which indicates there was an increase in student learning outcomes using Lecture Maker-based learning media. So, it can be concluded that the screen Lecture Maker used in making Arabic learning media in order to increase learning motivation and student learning outcomes.
Deconstruyendo el Síndrome de la Abeja Reina
Authors: Chuco Aguilar Victoria Judith
Published: August 2024

Introducción: El Síndrome de la Abeja Reina, un fenómeno en el que las mujeres que ocupan puestos de liderazgo inhiben el avance de otras mujeres, supone un reto importante en la búsqueda de la igualdad de género en el lugar de trabajo. Objetivo: Este estudio pretende explorar el Síndrome de la Abeja Reina dentro del marco de la teoría de la identidad social en el marco del comportamiento organizacional. Métodos: Se realizó una búsqueda bibliográfica exhaustiva utilizando términos clave como "Síndrome de la Abeja Reina", "desigualdad de género", "teoría de la identidad social" y "comportamiento organizacional" en varias bases de datos. Resultados: La revisión identifica que el Síndrome de la Abeja Reina exacerba las disparidades de género y contribuye a un ambiente de trabajo tóxico al reforzar los prejuicios de género y obstaculizar el avance profesional de las mujeres. Las raíces del síndrome se encuentran a menudo en la interiorización de atributos de liderazgo masculinizados y en prejuicios sociales que favorecen la dominación masculina. Conclusiones: Para abordar el Síndrome de la Abeja Reina se requiere un enfoque polifacético, que incluya garantizar una representación equilibrada de hombres y mujeres, promover modelos de conducta positivos e incorporar principios de igualdad en las políticas organizativas para fomentar un entorno más integrador y propicio para las mujeres.