bluuebunny/crossref_metadata_2025 huggingface dataset:
Establishment and Comparison of Piecewise Linear Regression Models to
Measure Thyroid Volume by 2D and 3D Ultrasound
Authors: Wang Yue-Gui , Yang Shu-Ping , Cai Ming-Yong , Chen Ke-Yue , Li Ting-Ting , Shen Hao-Lin
Published: September 2023

Objective:

Compared thyroid volumes measured by 2-D and 3-D US with those of resected specimens and proposed new models to improve measurement accuracy.

Methods:

This study included 80 patients who underwent total thyroidectomy. One 2D_model and one 3D_model were developed using piecewise linear regression analysis. The accuracy of these models was compared using an ellipsoid model (2-D_US value x 0.5), 3-D_US value, and Ying's model [1.76 + (2-D_US value x 0.38)].

Results:

The new 2D_model was: V=2.66 + (0.71 * X1) - (1.51 * X2). In this model, if 2-D_US value <= 228.39, X1 = 2-D_US value and X2 = 0; otherwise, X1 = 2-D_US value and X2 = 2-D_US value - 228.39. The 3D_model was: V= 2.90 + (1.08 * X1) + (2.43 * X2). In this model, if 3-D_US value <= 102.06, X1 = 3-D_US value and X2 = 0; otherwise, X1 = 3-D_US value and X2 = 3-D_US value - 102.06. The accuracy of the new models was higher than that of the 3-D_US value, the ellipsoid model, and Ying�s model (P<0.05).

Conclusion:

The models established are more accurate than the traditional ones and can accurately measure thyroid volume.
Analysis of Inhibition Potential of Nimbin and its Analogs against NF-κB Subunits
p50 and p65: A Molecular Docking and Molecular Dynamics Study
Authors: Khan Asiya , Singh Divyam , Waidha Kamran , Sisodiya Sandeep , Gopinath Pushparathinam , Hussian Showket , Tanwar Pranay , Katare Deepshikha Pande
Published: September 2023

Background:

Cancer remains the major cause of morbidity and mortality. The nuclear factor kappa-B (NF-
κB) plays an indispensable role in cancer cell proliferation and drug resistance. The role of NF-κB is not only limited
to tumor cell proliferation and suppression of apoptotic genes but it also induces EMT transition responsible for metastasis.
Inhibition of the NF-κB pathway in cancer cells by herbal derivatives makes it a favorable yet promising target
for cancer therapeutics.

Aim:

The purpose of the study is to explore the inhibition potential of Nimbin and its analogs against NF-κB subunits
p50 and p65.

Methods:

In the present study, an herbal compound Nimbin and its derivative analogs were investigated to examine
their impact on the p50 and p65 subunits of the NF-κB signaling pathway using in silico tools, namely molecular docking
and simulation.

Results:

The molecular docking analysis revealed that Nimbin and its analogs may bind to p50 and p65 subunits with
dG bind values ranging from -33.23 to -50.49Kcal/mol. Interestingly, molecular dynamic simulation for the NO5-p65
complex displayed a stable conformation and convergence when compared to the NO4-p50 complex.

Conclusion:

These results indicate that NO5 may have a potential inhibitory effect against NF-κB subunit p65, which
needs to be further validated in in vitro and in vivo systems. Also, the results obtained emphasize and pave the way for
exploring the Nimbin scaffold against NF-κB inhibition for cancer therapeutics.
A Case Presenting with Neck Pain and High Sedimentation Rate: Amyloid
Goiter
Authors: Gokbulut Puren , Koc Gonul , Firat Sevdenur , Oztekin Pelin , Celepli Pinar , Kökceoglu Seher , Culha Cavit
Published: September 2023

Introduction:

Amyloid goiter is a rare disease characterized by amyloid deposits that
cause sudden growth in the thyroid gland.

Case Presentation:

Here we present a case of a 26-year-old woman with euthyroid amyloid goiter
who presented with subacute granulomatous thyroiditis clinic. Amyloid goiter was detected as
a result of core biopsy from the thyroid parenchyma of the patient with sudden thyroid enlargement.
Surgery was not applied to the patient who had no pressure symptoms or signs. In systemic
amyloidosis secondary to Familial Mediterranean fever, heart and kidney involvement, as well as
the thyroid gland, were detected.

Conclusion:

Amyloid accumulation should be considered in addition to anaplastic thyroid cancer
and lymphoma in patients with sudden thyroid enlargement. It should not be overlooked that amyloid
goiter may mimic subacute thyroiditis clinic. Systemic amyloidosis should be considered in
patients with amyloid goiter, and an examination should be made to assess the presence of amyloid
accumulations in other organs.
Interleukin (IL)-23, IL-31, and IL-33 Play a Role in the Course of Autoimmune
Endocrine Diseases
Authors: Janyga Szymon , Kajdaniuk Dariusz , Czuba Zenon , Ogrodowczyk-Bobik Monika , Urbanek Agata , Kos-Kudła Beata , Marek Bogdan
Published: September 2023

Background:

Interleukins (IL)-23, 31, and 33 are involved in the regulation of T helper 17 (Th17)/regulatory T (Treg) cells balance. The role of IL-23, 31 and 33 in non-endocrine auto-immune diseases has been confirmed. Data on the involvement of these cytokines in endocrine autoimmune diseases are limited.

Objective:

This study aimed to determine the involvement of cytokines regulating the T helper 17 (Th17)/regulatory T (Treg) cells axis in the course of autoimmune endocrine diseases.

Methods:

A total number of 80 participants were divided into 4 groups: the autoimmune polyen-docrine syndrome (APS) group consisting of APS type 2 (APS-2) and type 3 (APS-3) subgroups, the Hashimoto's thyroiditis (HT) group, the Graves’ disease (GD) group and the control (C) group. Fifteen cytokines related to Th17 and Treg lymphocytes were determined in the serum of all participants.

Results:

Higher levels of IL-23 and IL-31 were found in the APS, GD, and HT groups compared to the C group. Higher levels of IL-23 and IL-31 were also observed in the APS-2 group, in contrast to the APS-3 group. Correlation analysis of variables in the groups showed a statistically signifi-cant correlation between the cytokines IL-23, IL-31, and IL-33 in the APS and APS-2 groups, but no correlation in the APS-3 and C groups.

Conclusion:

IL-23 and IL-31 are independent factors in the course of HT, GD, and APS-2, in contrast to APS-3. The positive correlation between IL-23 and IL-31, IL-23 and IL-33, and be-tween IL-31 and IL-33 in the APS, APS-2 groups, but the lack of correlation in the APS-3 and C groups may further suggest the involvement of these cytokines in the course of Addison's disease.
Determination of the Water use Efficiency of a Pecan Nut Orchard based on the Irrigation Scheduling and the Evapotranspiration Rate in Northern Mexico
Authors: Zermeño-González A. , Escalante-Pérez A. , Gil-Marín J. A. , Ramírez-Rodríguez H. , Cadena-Zapata M. , Melendres-Alvarez A.I. , Méndez-González J.
Published: September 2023

Background:

Adult pecan trees require a significant water supply for high yields and nut quality. Pecan nut orchards are established in semi-arid regions where water is the primary limiting resource for agriculture. Therefore, in these regions, improving water use efficiency is essential.

Objective:

Evaluate the water use efficiency of a pecan tree orchard based on the comparison of irrigation scheduling with the evapotranspiration rate data.

Methods:

The study was conducted in a pecan nut (Carya illinoinensis) orchard of 7.2 ha with 7-year-old Western and Wichita cv tress. The volume of water applied to each tree (drip irrigation) was converted to a daily irrigation depth and compared against the daily rate of actual (measured with an Eddy covariance system) and the FAO Penman-Monteith evapotranspiration.

Results:

Comparing the monthly water depth applied to each tree against the monthly FAO-Penman Monteith ET, surplus or deficit irrigation episodes were detected. Because the canopy trees only covered 18.7% of the orchard area, the daily rate of actual evapotranspiration during the months of the trees growing was very small (1 to 2 mm) compared with the orchards of mature pecan trees. The corresponding monthly crop coefficients (Kc) were also small (0.315 on average).

Conclusion:

This study showed that by comparing the rate of ETref against the irrigation depth applied to the trees in the irrigation scheduling, it is possible to reveal cases of surplus or deficit of water supplied to a pecan nut orchard.
At the Crossroads of TNF α Signaling and Cancer
Authors: Manohar Sonal M.
Published: September 2023

Tumor necrosis factor-alpha (TNFα) is a pleiotropic pro-inflammatory cytokine of the TNF superfamily. It regulates key cellular processes such as
death, and proliferation besides its well-known role in immune response through activation of various intracellular signaling pathways (such as
MAPK, Akt, NF-κB, etc.) via complex formation by ligand-activated TNFα receptors. TNFα tightly regulates the activity of key signaling proteins
via their phosphorylation and/or ubiquitination which culminate in specific cellular responses. Deregulated TNFα signaling is implicated in
inflammatory diseases, neurological disorders, and cancer. TNFα has been shown to exert opposite effects on cancer cells since it activates prosurvival
as well as anti-survival pathways depending on various contexts such as cell type, concentration, cell density, etc. A detailed
understanding of TNFα signaling phenomena is crucial for understanding its pleiotropic role in malignancies and its potential as a drug target or an
anticancer therapeutic. This review enlightens complex cellular signaling pathways activated by TNFα and further discusses its role in various
cancers.
Promising Anticancer Stand-ins of Phyllanthus Species
Authors: Simran  , Vani  , Kriplani Priyanka , Guarve Kumar
Published: September 2023

Background:

Phyllanthus species plants along with their active constituent phyllanthin, are the most widely used plants to cure various diseases. Present studies indicate their applicability as anti-diabetic, anti-malarial, antiplasmodial, anti-viral, anti-inflammatory, antibacterial, antioxidant, antineoplastic, diuretic, nephroprotective, hypolipidemic, and hepatoprotective properties.

Objective:

The objective of the present review is to study the recent literature and patents, including the various methods of extraction and isolation of phyllanthin along with its pharmacokinetics and clinical trials and mainly focussing on their anticancer potential along with a brief on other pharmacological activities.

Methods:

Recent prose and patents focussing on the anticancer potential of mainly P. amarus and P. niruri have been highlighted with special emphasis on scientific novelty and impact.

Results:

Both P.amarus and P.niruri displayed good anticancer potential in multiple tumors and synergistic effects when combined with other anticancer drugs. Ne isolation/extraction methods, clinical trials, and pharmacokinetic studies have been discussed.

Conclusion:

The anticancer potential of P.amarus and P.niruri has opened new avenues for further research. Clinical trials are the need of the hour to validate and confirm the tumor-suppressing properties of both plants.
In Silico Identification of Cadmium Binding Protein and its Secreted Metalloproteins
in Stenotrophomonas maltophilia
Authors: Ganapathy  Salini Nandhana , Majumdar Rikhia , Ahamad Shahjahan , Sugumar Shobana
Published: September 2023

Background:

Stenotrophomonas maltophilia is a pathogenic bacteria that causes serious
infectious complications in humans, especially in immune-compromised patients. Stenotrophomonas
maltophilia is a gram-negative bacterium that is multidrug-resistant.

Objective:

The purpose of the study is to understand the diverse cellular and biological functions of
cadmium-binding metalloproteins and to predict their role in pathogenicity, regulation, and growth.

Methodology:

Different in silico approaches were used to check the Functional Annotation, Subcellular
Localization, Gene Ontology, and Bacterial toxin prediction have been used to identify the cellular
and biological function of Cd-binding metalloproteins in Stenotrophomonas maltophilia.

Results:

Identified 116 Cd-binding proteins from the whole proteome sequence and functional domain,
family, localization, and toxicity were also studied.

Conclusion:

The outcomes revealed that this study could be used in understanding the 116 cadmiumbinding
proteins from the whole proteome sequence. This study shows the survival, growth, and pathogenicity
of the bacteria.
Karnasphota: A Neuroprotective Herb from the Treasure of Ayurveda
Authors: Topiya H. R. , Pandya D. J.
Published: September 2023

The ancient science of life known as Ayurveda offers countless potential to uncover
many unexplored manuscripts that lead to effective medications. Understanding traditional medicinal
plants can open up a wealth of significant bioactive phytoconstituents with numerous significant
pharmacological functions. This treasure must be located based on the understanding of old Ayurveda
and other traditional references. Sapindaceae family member Cardiospermum halicacabum
Linn. is a rich source of phytochemicals, including tannins, saponins, phenols, flavonoids, terpenoids,
alkaloids, and sterols. Many of these phytochemicals exhibit antioxidant, anxiolytic, antiinflammatory,
anti-ulcer, anti-cancer, anti-microbial, antifungal, anti-bacterial, anti-diabetic, immunomodulatory,
antiviral, cardioprotective, mainly neuroprotective properties according to Ayurveda.
The plants' aerial parts are rich in phenolic acids, glycosidic compounds, tannins, and sterols.
Researchers and academicians are examining the pharmacognosy, phytochemistry, and other pharmacological
effects of the traditional medicinal plant known as Karnasphota (Cardiospermum halicacabum
Linn.), which is cited in Ayurveda as one of the neuroprotective agents. Karnasphota
(Cardiospermum halicacabum Linn.) is shown to have promising therapeutic potential by the scientific
evidence offered by researchers and academics, and it can be further assessed as a novel candidate
for drug discovery. The current review aims to examine the potential of the underexplored herb
from Ayurveda "Karnasphota" for developing and designing future medications by reviewing the
existence of medicinally significant secondary metabolites, potential pharmacological importance,
and its role in neuroprotection in neurodegenerative diseases.
Systematic Review on Characterization of Tannase from Agricultural By-Products
Authors:   Universiti Teknologi MARA, Shah Nurul Adlin Azaman , Mansor Azlina ,   Malaysian Agricultural Research and Development Institute, Manikam Raseetha Vani Siva ,   Universiti Teknologi MARA
Published: September 2023

Tannin-rich compounds are widely produced as by-products of many agro-industrial processes. Tannase is an attractive hydrolase for the bioconversion of tannin-rich materials into value-added products by accelerating the hydrolysis of ester and depside linkages. It has opened new opportunities in several industrial sectors, such as food, drinks, and medicines. Primary sources of tannase are microorganisms, particularly bacteria. Tannases or tannin acyl hydrolases, are an important group of biotechnologically relevant enzymes in several industrial applications. Microbial tannases are mostly induced extracellular enzymes produced by submerged and solid-state fermentation. Tannins containing low-value agro-industrial wastes are being extensively used in industries. This review provides a more in-depth knowledge of the research related to the biochemical characteristics of the tannase enzyme activity (in terms of molecular weight, the effect of pH, the effect of temperature, the effect of metal ions, inhibitor, and chelator), extraction, and purification methods. Additionally, the potential use of agricultural waste as a substrate for tannase production has also been reviewed, including the utilization of pomegranate peel waste (PmPW), banana peel waste (BPW), or potato peel waste (PtPW).
The Effects of Exercise on Synaptic Plasticity in Individuals With Mild Cognitive Impairment: Protocol for a Pilot Intervention Study
Authors: Ramdeo Karishma R , Fahnestock Margaret , Gibala Martin , Selvaganapathy Ponnambalam Ravi , Lee Justin , Nelson Aimee Jennifer
Published: September 2023

Background

Mild cognitive impairment (MCI) is a syndrome preceding more severe impairment characterized by dementia. MCI affects an estimated 15% to 20% of people older than 65 years. Nonpharmacological interventions including exercise are recommended as part of overall MCI management based on the positive effects of exercise on cognitive performance. Interval training involves brief intermittent bouts of exercise interspersed with short recovery periods. This type of exercise promotes cognitive improvement and can be performed in individuals with MCI. Synaptic plasticity can be assessed in vivo by the neurophysiological response to repetitive transcranial magnetic stimulation (rTMS). A method to assess synaptic plasticity uses an intermittent theta burst stimulation (iTBS), which is a patterned form of rTMS. Individuals with MCI have decreased responses to iTBS, reflecting reduced synaptic plasticity. It is unknown whether interval training causes changes in synaptic plasticity in individuals living with MCI.

Objective

This research will determine whether interval training performed using a cycle ergometer enhances synaptic plasticity in individuals with MCI. The three aims are to (1) quantify synaptic plasticity after interval training performed at a self-determined intensity in individuals with MCI; (2) determine whether changes in synaptic plasticity correlate with changes in serum brain-derived neurotrophic factor, osteocalcin, and cognition; and (3) assess participant compliance to the exercise schedule.

Methods

24 individuals diagnosed with MCI will be recruited for assignment to 1 of the 2 equally sized groups: exercise and no exercise. The exercise group will perform exercise 3 times per week for 4 weeks. Synaptic plasticity will be measured before and following the 4-week intervention. At these time points, synaptic plasticity will be measured as the response to single-pulse TMS, reflected as the percent change in the average amplitude of 20 motor-evoked potentials before and after an iTBS rTMS protocol, which is used to induce synaptic plasticity. In addition, individuals will complete a battery of cognitive assessments and provide a blood sample from the antecubital vein to determine serum brain-derived neurotrophic factor and osteocalcin.

Results

The study began in September 2023.

Conclusions

The proposed research is the first to assess whether synaptic plasticity is enhanced after exercise training in individuals with MCI. If exercise does indeed modify synaptic plasticity, this will create a new avenue by which we can study and manipulate neural plasticity in these individuals.

Trial Registration

ClinicalTrials.gov NCT05663918; https://clinicaltrials.gov/study/NCT05663918

International Registered Report Identifier (IRRID)

PRR1-10.2196/50030
The Effectiveness of Video-Based Game Exercise Therapy Applications in Pes Planus Rehabilitation: Protocol for a Randomized Controlled Trial
Authors: Erten Ayşe Büşra , Tarakçı Devrim , Çaçan Mehmet Akif
Published: September 2023

Background

Pes planus is one of the most common foot deformities. Although there are many studies on the effectiveness of various exercise methods in pes planus rehabilitation, the number of studies on video-based game exercise therapy applications is very limited.

Objective

This study aims to evaluate the effectiveness of 2 video-based game exercise therapies and structured exercise practices in pes planus rehabilitation.

Methods

This study is a 3-arm, parallel-group, single-blinded randomized controlled trial. The study will include 69 patients with flexible pes planus aged between 18 and 25 years who attend the orthopedics and traumatology clinic and meet the inclusion criteria. The primary outcomes are measures of navicular drop and pedobarographic analysis before and after the intervention, and the secondary outcomes include balance, femoral anteversion, and lower extremity muscle strength. Participants will be evaluated with a navicular drop test for medial longitudinal arch height, a pedobarographic analysis system for plantar pressure analysis, a Craig test for femoral anteversion, the Becure Balance System for balance measurement, and a myometer device for lower extremity muscle strength measurement. Participants will be randomly assigned to a structured exercise group, an exergame group, or a serious game group according to their order of arrival. The structured exercise group will use a short foot exercise, a towel-picking exercise, and various walking and balance exercises. Patients in the serious play group will play the lower extremity games in the Becure Balance System. Patients in the exergame group will play balance games on the Nintendo Wii game console. All participants will participate in 18 exercise sessions (3 days a week for 6 weeks). After the treatment, the initial measurements will be repeated.

Results

The study started in January 2023. It is expected to be completed in June 2024.

Conclusions

This study will be the first randomized controlled study to evaluate the effectiveness of 2 different video-based game exercise therapy applications in pes planus rehabilitation. Through this study, the use of video-based game exercise therapy in pes planus rehabilitation, together with the developing technology, will be a guide. In addition, a new exercise protocol, including serious game exercises, will be added to the literature. In the future, it is expected that our study on the development of different game systems, especially for the ankle, will provide pioneering feedback.

Trial Registration

ClinicalTrials.gov NCT05679219; https://clinicaltrials.gov/study/NCT05679219

International Registered Report Identifier (IRRID)

DERR1-10.2196/51772
Validation of Indonesian Version of Telehealth Usability Questionnaire (TUQ)
Authors: Octavius Gilbert Sterling , Yanto Theo Audi
Published: September 2023

Introduction: Indonesia is the 4th most populous country globally, with 250 million people spread across 17.508 islands. Despite its strong economic growth, the disparity in poverty increases as the cost of medical care shot up. With inadequate medical care worker-to-patient ratio, telehealth is an alternative to providing healthcare in rural areas with similar or even better satisfaction rates. The lack of a standardized questionnaire in the Indonesian language encouraged the authors to validate Telehealth Usability Questionnaire (TUQ) into the Indonesian language.Methods: A cross-sectional study was done while translation and adaptation of telehealth usability questionnaires were made according to WHO protocol.Results: A total of 102 respondents' data were obtained, which comprised 73.5% female. The overall alpha coefficient was 0.958. The Kaiser–Meyer–Olkin (KMO) sampling test was satisfactory (KMO = 0.926), and the Bartlett test of sphericity was significant (Chi-square = 1835.043; df = 210; p < 0.001). Ease of use and learnability had the highest Cronbach's alpha coefficient (0.907), while reliability had the lowest Cronbach's alpha coefficient (0.794).Conclusion: In conclusion, this questionnaire is one of the first ones, if not the first one, to be validated in the Indonesian language. This set of questions will help assess the usability of the expanding number of telehealth programs available in Indonesia and allow comparisons to determine which features make them more acceptable to users
Optimization of Counseling Services at the Desks to the Four Posyandu
Authors: Indrayani Novi
Published: September 2023

During providing services Posyandu Lestari I and Ringinsari I only include anthropometric measurements in infants and toddlers, complementary breastfeeding, immunization, administration of Vitamin A and Deworming (February and August), while counseling services for mothers and toddlers of babies at the tables of four posyandu have not been implemented.  Counseling at Posyandu will only be carried out when there are health workers who visit, which is usually only in February and August every year. The purpose of this community service is to improve the services provided by the posyandu, one of which is to reactivate the fourth table. The service at the fourth table is the  service provided by the cadre in the form of counseling for infant and toddler mothers The method used in education on improving posyandu services is training on the use of posyandu backsheets to assist cadres in providing counseling at the fourth table of the posyandu.  The result obtained from this Community Service is that there are differences in providing counseling before and after getting education on the use of backsheets for counseling at the desks of the four posyandu. Counseling services at the fourth table can increase the satisfaction of mothers of babies and toddlers in receiving services at posyandu.
Policy Conflict: A Conflict Analysis of the Relocation Policy of Street Vendors in Simpang Lima, Pati Regency
Authors: Walinegoro Bhakti Gusti , Fitriyono Junaidul
Published: September 2023

This study aims to analyse the conflicts that stemmed from the relocation of street vendors in Simpang Lima, Pati Regency. This conflict is distinct because it is not only related to the refusal to relocate and improve facility quality, but also local government policies that failed to comprehensively address the problem, thereby wasting time and funds. This qualitative research adapts the Policy Conflict Framework (PCF) to analyse data collected through interviews and literature studies. It thus applies the latest and most appropriate framework for comprehensively analysing policy conflicts, particularly those related to the power relations between stakeholders. In so doing, it finds that relocation resulted from a regulatory mandate that was based on considerations made by the government when carrying out public governance. However, this policy created conflicts due to problems with its content and processes. The conflict in this study is evidence that involved actors’ willingness to compromise is one important factor in reducing conflict intensity.
The Flexible Role of Middlemen in the Nutmeg Distribution Scheme in Maluku
Authors: Baso Avryana , Dana I Gusti Ngurah Krisna , Syamsuri Ulfa Aulia
Published: September 2023

Nutmeg cultivation in Banda Neira integrally involves middlemen, brokers who connect nutmeg farmers with the global market. Studies of such middlemen tend to emphasise the negative effects of their relationship with farmers. However, some research on their positive impact has also been conducted. This study seeks to explain the positive effects of middlemen by describing the flexibility of the brokered system. This descriptive-qualitative research, using data sourced from a study of the literature as well as interviews with resource persons, finds that flexibility has been created with the support of a communal social system that has carefully been maintained by middlemen in the nutmeg distribution scheme and supply chain. In the nutmeg distribution scheme, farmers have the option to sell nutmeg to a private actor—PT Kamboti —, but this option is not accessible to all smallholders because of the company’s profit-oriented (market) logic. This study concludes that middlemen play a flexible role, one which is positively and highly related to the social context that they have helped create and maintain. These middlemen tend to present themselves as the brothers, or at least relatives, of the farmers. As these middlemen prioritise social approaches to increase social bonding, there is no resistance to their involvement in the nutmeg distribution scheme in Maluku.
Buruh Digital dan Negosiasi Kuasa: Siasat Komunitas Freelancer Indonesia Menghadapi Kerentanan Kerja di Tengah Kekuasan Asimetri Perusahaan Platform
Authors: Khawarizmi Kalam
Published: September 2023

Perkembangan internet melahirkan sistem kerja berbasis platform yang memberikan kemudahan sekaligus kerentanan bagi pekerja digital. Tulisan ini menganalisis siasat yang dilakukan buruh digital berbasis cloud dalam merespons kerentanan yang mereka alami di tengah praktik kekuasaan asimetri pada sistem ekonomi platform di Indonesia. Kajian ini menggunakan pendekatan mix-method analysis, yaitu kuantitatif dan kualitatif untuk menghasilkan data kajian yang terperinci dan mendalam. Untuk menganalisis data yang sudah dikumpulkan, tulisan ini menggunakan teori flexibility of labour market milik Schmidt (2017), yakni untuk menganalisis kerentanan yang dialami pekerja cloud dan teori etika subsistensi milik Scott (1989) untuk menganalisis siasat yang dilakukan pekerja cloud dalam merespons kerentanan yang mereka alami. Hasil kajian menunjukkan bahwa pekerja cloud mampu melakukan siasat dengan memanfaatkan ruang negosiasi dari praktik kekuasaan asimetri dengan cara memiliki pekerjaan tambahan untuk menambah penghasilan, meminimalisir pengeluaran, memanfaatkan jejaring di luar keluarga, dan menyesuaikan porsi pekerjaan untuk mengurangi risiko kecelakaan kerja.
Más allá de toda duda razonable: su papel en materia penal
Authors: Soto Prats Bárbara
Published: September 2023

El artículo destaca la importancia de los hechos en el derecho y cómo estos son esenciales para aplicar normas y sus consecuencias jurídicas. Sin embargo, la valoración de las pruebas y su relevancia es un tema aún emergente en la doctrina y jurisprudencia. Se introduce el concepto de "estándares probatorios", que establecen reglas básicas para que los jueces evalúen las pruebas. En el ámbito penal, Costa Rica utiliza el estándar "más allá de toda duda razonable", priorizando la absolución de un posible culpable sobre la condena de un inocente. A pesar de su importancia, este estándar no está claramente definido en la legislación ni en su aplicación. Además, los tribunales superiores, como la Sala Tercera, han evitado revisar la valoración de pruebas de instancias inferiores, limitando el control y revisión.
Políticas públicas de la Unión Europea y España en protección de los derechos de mujeres y niñas víctimas de trata de seres humanos para explotación sexual
Authors: Rodríguez Rodríguez Francisco Miguel
Published: September 2023

El texto examina las políticas públicas en la Unión Europea y España en relación a la trata de mujeres y niñas con fines de explotación sexual, evaluando si adoptan una perspectiva de género. También considera la utilidad de un enfoque interseccional para mejorar las Directivas relacionadas con la trata, con el objetivo de abordar de manera más integral las necesidades específicas de mujeres y niñas víctimas de diferentes experiencias de vulnerabilidad. Además, se investiga si la explotación sexual de mujeres y niñas a través de la trata recibe más atención en términos de implementación que otras formas de trata. Finalmente, se analiza la eficacia de la detección e identificación de menores víctimas de trata de seres humanos, y si esta garantiza una protección completa para las víctimas.
La paz total en Colombia: el desafío a las interacciones y multiplicidades ilícitas, la seguridad nacional y la política criminal
Authors: Mesa Cárdenas William Andrés
Published: September 2023

Este estudio aborda el concepto de "paz total" y su influencia en áreas clave del Estado, como la seguridad ciudadana, la política criminal y la relación Estado-ciudadanía, con un enfoque particular en Colombia. Mediante un enfoque cualitativo e interdisciplinario, se examina la relación de la paz total con las actividades ilícitas, la seguridad nacional y la política criminal. Las conclusiones revelan que la visión de paz total del gobierno de Gustavo Petro (2022-2026) presenta desafíos significativos para el Estado y la sociedad civil, considerando la diversidad de grupos armados ilegales y sus distintas características y objetivos.
La política europea de desarrollo de competencias para la sostenibilidad, la justicia social y la resiliencia: el rol del emprendimiento
Authors: Llorente Portillo Carolina
Published: September 2023

Este estudio se centra en la política europea de fomento de competencias orientadas a la sostenibilidad, justicia social y resiliencia, con especial énfasis en la competencia emprendedora. A través del análisis de diversas iniciativas y marcos europeos, se evidencia el esfuerzo de la Unión Europea por alinear las habilidades con las demandas de un mercado laboral en evolución hacia una economía más verde y digitalizada. Además, se subraya la relación de estas políticas con la estructura económica y presupuestaria de la Unión, apoyada por fondos como el Mecanismo de Recuperación y Resiliencia.
Otero Salas, Filiberto. Derecho Administrativo, México, Tirant lo Blanch, 2023.
Authors: Hernández Arana Brenda A
Published: September 2023

La obra del Dr. Filiberto Otero Salas aborda exhaustivamente el Derecho Administrativo Mexicano a través de diez unidades temáticas. Estas unidades exploran desde los orígenes y evolución del Derecho Administrativo, pasando por la función pública del Estado, el poder ejecutivo, la administración pública, la legislación administrativa, la ética pública, el patrimonio público, hasta llegar a temas de transparencia, participación ciudadana y responsabilidad patrimonial del Estado. El autor destaca la importancia de la ética pública y la transparencia como pilares fundamentales para combatir la corrupción y fortalecer el Estado de derecho. La obra se presenta como una herramienta esencial para profesionales, académicos y estudiantes del Derecho, ofreciendo una visión contemporánea y vanguardista del Derecho Administrativo en México y Latinoamérica.
Operational Quantum Average-Case Distances
Authors: Maciejewski Filip B. , Puchała Zbigniew , Oszmaniec Michał
Published: September 2023

We introduce distance measures between quantum states, measurements, and channels based on their statistical distinguishability in generic experiments. Specifically, we analyze the average Total Variation Distance (TVD) between output statistics of protocols in which quantum objects are intertwined with random circuits and measured in standard basis. We show that for circuits forming approximate 4-designs, the average TVDs can be approximated by simple explicit functions of the underlying objects – the average-case distances (ACDs). We apply them to analyze the effects of noise in quantum advantage experiments and for efficient discrimination of high-dimensional states and channels without quantum memory. We argue that ACDs are better suited for assessing the quality of NISQ devices than common distance measures such as trace distance or the diamond norm.
Quantum Interior Point Methods for Semidefinite Optimization
Authors: Augustino Brandon , Nannicini Giacomo , Terlaky Tamás , Zuluaga Luis F.
Published: September 2023

We present two quantum interior point methods for semidefinite optimization problems, building on recent advances in quantum linear system algorithms. The first scheme, more similar to a classical solution algorithm, computes an inexact search direction and is not guaranteed to explore only feasible points; the second scheme uses a nullspace representation of the Newton linear system to ensure feasibility even with inexact search directions. The second is a novel scheme that might seem impractical in the classical world, but it is well-suited for a hybrid quantum-classical setting. We show that both schemes converge to an optimal solution of the semidefinite optimization problem under standard assumptions. By comparing the theoretical performance of classical and quantum interior point methods with respect to various input parameters, we show that our second scheme obtains a speedup over classical algorithms in terms of the dimension of the problem n, but has worse dependence on other numerical parameters.
Nitrogen-Doped Carbon Dots From Bilimbi Juice (Averrhoa bilimbi L.) Via Hydrothermal Method For Iron and Mercury Sensing
Authors: Piliang Averroes Fazlur Rahman , Tarigan Kerista , Humaidi Syahrul , Barus Diana Alemin , Gea Saharman
Published: September 2023

Abstract: Carbon dots (CDs) have been widely used in various applications, one of them being metal ion sensing. Synthesizing CDs with sensing characteristics is influenced by two factors, i.e., precursor and dopant agent. This study aims to use bilimbi (Averrhoa bilimbi) with N, N-dimethylformamide (DMF) as a nitrogen source to synthesize CDs via the hydrothermal method. The result of hydrothermal showed significant colors of CDs with and without the presence of nitrogen, and these behaviors were also confirmed by the differential absorption of the CDs, with λmax of absorption at 291 nm. FTIR spectra confirmed the presence of functional groups related to CDs, such as C-H, C=H, C=N, C=O, C-O-C, and NH2. Meanwhile, emission spectra displayed fluorescent emission at λmax 495 nm (DMF 2%) and 491 nm (DMF 4%). The ion metal sensing test showed that these two samples with 2% and 4% of DMF were sensitive to Fe3+ and Hg2+ sensing. These characteristics concluded that NCDs from bilimbi juice via hydrothermal method were able in sensing metal ions, such as Fe3+ and Hg2+.Abstrak: Karbon dots (CDs) telah banyak diterapkan pada berbagai penggunaan, salah satunya adalah sebagai alat pendeteksi ion logam. Sintesis Cds dengan kemampuan mendeteksi dipengaruhi oleh dua faktor, yaitu prekursor dan agen dopant. Penelitian ini bertujuan untuk menggunakan asam belimbing wuluh (Averrhoa bilimbi) dengan penambahan N, N dimetilformamida (DMF) sebagai sumber nitrogen sebagai bahan sintesis CDs melalui metode hidrotermal. Hasil hidrotermal menunjukkan perbedaan emisi warna dari CDs dengan dan tanpa penambahan DMF, dan karakteristik ini juga ditunjukkan dengan adanya perbedaan penyerapan panjang gelombang maksimum (λmax) di 291 nm. Spektra FTIR juga mengkonfirmasi adanya gugus fungsi terkait dengan CDs, seperti C-H, C=H, C=N, C=O, C-O-C, dan NH2. Sementara itu, emisi spekra menunjukkan emisi fluorosensi pada λmax sebesar 495 nm (DMF 2%0, dan 491 nm (DMF 4%). Pendeteksian ion logam pada kedua sampel sensitif pada ion Fe3+ dan Hg2+. Karakteristik ini menyimpulkan bahwa NCDs dari jus asam belimbing dapat digunakan sebagai alat pendeteksi ion logam dalam air, khususnya pada ion logam besi dan merkuri.
Production of Graphene By Coconut Shell As an Electrode Primary Battery Cell
Authors: Pasaribu Elsa , Siburian Rikson , Supeno Minto
Published: September 2023

Abstract: Coconut shells are a natural resource that contains a lot of carbon (C). The pyrolysis process can be used to create coconut shells. A single layer of carbon atoms that have undergone sp2 hybridization to form a hexagonal, two-dimensional structure is known as Graphene. Graphene has excellent potential for battery manufacturing applications, supercapacitors, etc. Activated carbon and the pyrolisis method of producing Graphene were combined and heated to 600 oC for one hour. The graphene generated is assessed using an XRD, SEM-EDX, TEM, Raman, and conductometer. The results of the X-ray diffractogram analysis revealed that the peaks at 2θ = 23,87o and 44,5o are not particularly sharp and slightly broadened. It means Graphene are well formed. SEM-EDX investigation reveals that the surface size and shape structure is smaller and thinner, a flat pile dominated by carbon atoms. The result of conductometer analysis shows the electrical conductivity of Graphene is quite good, but Graphene can still not control the movement of electrons. Graphene has layer distances between Graphene and Graphene layers are 3.3 Å (TEM data), with many Graphene layers being 0.85 (multi-layer) (Raman data).Abstrak: Batok kelapa merupakan salah satu sumber daya alam yang mengandung banyak karbon (C). Proses pirolisis dapat digunakan untuk membuat batok kelapa. Satu lapisan atom karbon yang telah mengalami hibridisasi sp2 untuk membentuk struktur dua dimensi heksagonal dikenal sebagai Grafena. Grafena memiliki potensi besar untuk aplikasi pembuatan baterai, superkapitasitor, dan sebagainya. Karbon aktif dengan metode pirolisis untuk memproduksi Grafena dipanaskan hingga 600 oC selama satu jam. Grafena yang dihasilkan dikarakterisasi menggunakan XRD, SEM-EDX, TEM, Raman, and Konductometer. Hasil analisis difraktogram sinar-X mengungkapkan bahwa puncak pada 2θ = 24,22o dan 44o tidak terlalu tajam dan sedikit melebar. Ini berarti Grafena terbentuk dengan baik. Analisis SEM-EDX mengungkapkan bahwa ukuran permukaan dan struktur bentuk lebih kecil dan lebih tipis dan itu adalah tumpukan datar yang didominasi oleh atom karbon. Hasil analisis konduktometer menunjukkan konduktivitas listrik Grafena cukup baik, namun Grafena masih belum mampu mengontrol pergerakan elektron. Grafena memiliki jarak lapisan antara lapisan  Grafena dan Grafena adalah 3,3 Å (data TEM) dengan jumlah lapisan Grafena adalah 0,85 (multilapisan) (data Raman).
The Predictive Power of Social Media Data
Authors:   , Lassen Niels Buus
Published: September 2023

Predictive analytics using social media data is a relatively new field, being widely recognized at first due to “Predicting the Future with Social Media” of Asur and Huberman (2010). Their article proposed a model that could predict the revenues of Hollywood movies using Twitter data as input. This model has proven more accurate than the golden standard for movie revenue prediction – the Hollywood Stock Exchange – being thus a betting market for Hollywood movie performances and considered a good prediction market example. Since 2010, predictive analytics using social media data have developed extensively. In line with this trend, this PhD thesis presents pioneering research on the first Twitter-based prediction sales model, which explains why Twitter data can predict iPhone sales. It also demonstrates that similar predictive sales models can be built using Facebook and Google search data. The methodology is based on customer journey models, which are the main conceptual models for categorizing all social media and web search data in a sales context. Based on this methodology, an investor journey model for categorizing web search data in a financial market context is proposed.
Ethical Climate and Associated Factors: Systematic Literature Review. Ethical Climate: Systematic Review
Authors: Schaefer Rafaela , Pereira da Silva Lopes Priscila , Goulart Domingues Camila , Teixeira Ortega Martina , Ferreira Ribeiro Francine , Zen Ramos Manoela
Published: September 2023

An organization’s ethical climate reflects organizational practices, procedures, and policies with moral consequences and demonstrates the influence of the workplace on ethical practice. The aim of this article is to analyse ethical climate in health care facilities and the factors associated therewith. This is a systematic literature review. The searches were conducted in January 2023 in the Embase, Scopus, PUBMED, and BVS databases using the keyword ‘hospital ethical climate survey’. Studies that had administered the 26-item scale in its original, translated or adapted version to health care professionals and described their respective scores were included. Studies that used the HECS in a reduced form, as well as theoretical studies, reviews, theses, and dissertations, were excluded. Twenty-three studies published between 2009 and 2022 were selected. The mean score for organisational ethical climate was 3.51, and scores ranged from 3.19 to 3.82, with the less ethical climate scores for the ‘physicians’ subscale and the highest scores for the ‘peers’ subscale.The organizational ethical climate showed a statistically significant association with sociodemographic and work variables: a positive ethical climate reduces moral distress, burnout, mistakes, and intention to leave the job, while it increases job satisfaction, ethical leadership, perceptions of quality, competence, and empowerment. The organizational ethical climate can affect the decision-making and ethical behaviour of health care professionals, thus influencing workplace well-being and the quality of care delivered. Actions to promote a positive ethical climate should be implemented.
Atuação da terapia ocupacional na síndrome de Williams-Beuren: relato de caso
Authors:   , Megid Luísa , Simões Nicole Maria da Silva
Published: September 2023

INTRODUÇÃO: O presente estudo discute a importância da autonomia e independência na vida da pessoa com Síndrome de Williams-Beuren (SWB), sobretudo na fase de transição da infância para a adolescência. Discorre sobre as características evidentes na síndrome, o contexto perante a inserção no mercado de trabalho, a contribuição da terapia ocupacional neste contexto no que diz respeito aos papéis ocupacionais na vida escolar e social, a partir do reconhecimento de suas potencialidades a fim de ressignificar e readaptar seu cotidiano. MÉTODO: Para este relato foi utilizado um estudo de caso desenvolvido no componente curricular de Terapia Ocupacional na Saúde do Trabalhador no primeiro semestre de 2022. Desenvolveu-se uma entrevista qualitativa descritiva e com base em um roteiro próprio de anamnese visou coletar informações relativas à identificação pessoal da jovem, seu conhecimento do trabalho, suas respectivas funções e avaliar os aspectos psicomotores. RESULTADOS: Participaram desse estudo uma mãe e sua filha de 14 anos com SWB, cuja jovem está vivenciando o momento de transição e inserção no mercado de trabalho como jovem aprendiz em uma microempresa familiar. DISCUSSÃO: Partindo dos objetos de avaliação, observou-se as possíveis intervenções da terapia ocupacional no contexto da vida cotidiana das participantes, com influência positiva nos aspectos abordados. CONCLUSÃO: Os déficits impostos por uma síndrome rara não impedem a promoção da participação social e inserção sociocultural. Destaca-se a complexidade que existe no cuidado da jovem no que se refere principalmente ao contexto escolar, os impactos psíquicos subjetivos provocados e as implicações que reverberam nas relações familiares.
O ensino de literatura em perspectiva dialógica
Authors:   , Arruda Rodrigo de Souza
Published: September 2023

A abordagem utilizada no ensino de literatura nas escolas públicas brasileiras se mantém a mesma desde meados do século XIX. Sendo ensinada a partir de uma perspectiva conteudista e enciclopédica. As aulas de literatura, muitas vezes, utilizam de textos literários não como objeto básico de análise, mas como exemplificação da teoria didática desenvolvida frequentemente por livros/manuais didáticos e exames. Muitas vezes, os atuais métodos de ensino de literatura têm dificultado a formação de bons leitores nas instituições públicas de ensino médio brasileiro que se demonstram despreparados ao realizar, principalmente, o ENEM. William Cereja, o autor mais utilizado no ensino de Língua Portuguesa no ensino médio pelas escolas públicas no Estado de São Paulo, traz uma nova proposta para um ensino de literatura mais eficaz e proveitoso para a formação de leitores capacitados a partir da perspectiva dialógica. Este trabalho tem como objetivo compreender como o ensino de literatura sob uma perspectiva dialógica pode colaborar para a formação de bons leitores. Embasa-se, teórico-metodologicamente, nos estudos de Bakhtin para se compreender o que está envolvido na leitura de um texto: sua análise e as múltiplas dimensões responsáveis pela construção de sentido. Como resultado, procura-se associar como o ensino de literatura em perspectiva dialógica proposto por William Cereja pode contribuir para a formação de bons leitores.
A guerra às drogas e a criminalidade transnacional: o caso do primeiro comando da capital (PCC) no Brasil
Authors:   , Lava Maria Laura Calhares da Costa
Published: September 2023

O presente trabalho busca investigar a atuação do Primeiro Comando da Capital como facção hegemônica paulista no interior do Brasil, desde os primórdios de sua existência, até sua consolidação como organização transnacional, a fim de entender se a mesma tem impactos diretos nas taxas de criminalidade do país. A análise foi feita através de referências bibliográficas e dados fornecidos pelo governo, e se inicia a partir do entendimento de Guerra às Drogas, declarada pelos Estados Unidos, e sua influência direta nos assuntos de segurança nacional do Brasil e dos demais países da América do Sul, sob o olhar da Teoria Construtivista e de Securitização das Relações Internacionais, num período de 1989 à 2019.