bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Literasi Keuangan, Kualitas SDM, dan Kemudahan Akses Pembiayaan Mikro Syariah Terhadap Perkembangan UMKM di BMT Beringharjo KCP Dolopo
Authors: Syahru Rofah Febrianti  , Ajeng Pipit Fitriani
Published: July 2024

Low levels of financial literacy can be an obstacle to business development. Human resource quality problems such as lack of skills, low productivity, or inability to adapt to market changes. Lack of access to microfinance can hinder business expansion and business diversification. The aim of this research is to determine and test the influence of financial literacy, quality of human resources, and ease of access to sharia microfinance on the development of MSMEs. This research uses quantitative methods, data collection using a questionnaire of 100 respondents. The results show that financial literacy has a negative and significant effect on the development of MSMEs, the quality of human resources has a positive and significant effect on the development of MSMEs, and Ease of Access to Sharia Microfinance has a positive and significant effect on the development of MSMEs. The results of the F Test show that the three independent variables have a simultaneous influence on the development of MSMEs.
Pengaruh Gaya Kepemimpinan, Pelatihan Kerja, dan Kompensasi terhadap Kinerja Karyawan di PO Gunung Harta Ponorogo
Authors: Ferawidianti Widianti  , Kenlies Era Rosalina Marsudi
Published: July 2024

Employee performance is the final result achieved by individuals in the form of goods or services, which must be by the agreed quality or standards in terms of cost, time, quality, and quantity. At the Gunung Harta Ponorogo Branch Office, various performance problems have emerged, such as bus delays, decreased ticket sales, customer complaints regarding unsatisfactory service, unfriendly attitudes, delays in departure, lack of coordination between teams, and lack of responsiveness. This study aims to analyze the effect of leadership style, job training, and compensation on employee performance partially and simultaneously. The method used is quantitative, with data collection through questionnaires to 50 Gunung Harta Ponorogo Branch Office employees using saturated samples. Instrument testing includes validity and reliability tests, while data analysis is carried out by descriptive analysis, classical assumption test, and multiple regression analysis. The findings show that leadership style positively and significantly influences employee performance. Then job training has a positive and significant influence on employee performance. And finally compensation also has a positive and significant influence on employee performance.
Pelos caminhos do estudo de aula
Authors: Scheller Morgana , Zabel Marília , Voigt Johann Felipe , Fiamoncini Patrícia de Souza , Hackbarth Rosane , Girardi Nilva Borba
Published: July 2024

O estudo de aula (EA) vem sendo aventado no mundo como um processo de desenvolvimento profissional pautado nas principais dificuldades de aprendizagem dos estudantes percebidas pelos professores participantes. Esse processo possibilita aos professores o aprofundamento de seus conhecimentos sobre a aprendizagem dos estudantes e o modo de promovê-la na sala de aula. Este texto tem como objetivo compartilhar com o público ações decorrentes do referido ciclo, colocando em tela vivências e experiências da qual participaram treze pessoas: professores que ensinam matemática nos anos finais do ensino fundamental/médio, formadores do IFC campus Rio do Sul, uma licenciada em matemática e acadêmicos do curso de Licenciatura em Matemática do campus. Constatamos que o EA se constitui como espaço potencial de formação coletiva, colaborativa e reflexiva – tendo sido legitimado pelos participantes tal potencial. Percebemos a importância de estar em um grupo colaborativo, em que se reconhece e destaca-se a importância do domínio do conteúdo, do planejamento anterior à docência, do modo como se interage com os estudantes nas aulas, do modo como a participação no grupo reconfigura percepções práticas docentes. Por fim, a participação no ciclo contribuiu para provocar mudanças de concepções e de ação docente, com a reconfiguração e a ampliação de saberes, bem como a percepção sobre a pertinência de estar em grupo refletindo sobre os desafios do professor que ensina matemática na Educação Básica.
Concurso dos melhores vinhos e sucos de uva do Planalto Norte Catarinense – edição 2022
Authors: Würz Douglas André , Kowal Alcemir Nabir , Silva Maciel Thalia Aparecida , Schmidt Eduarda , Levandoski Jansen Thuany Aparecida , Souza Farias Eduardo Virmond , Tschoeke Steidel Otávio Frederico , Palinguer Rodrigo
Published: July 2024

Em função da grande repercussão das edições 2019 e 2021 do Concurso dos Melhores Vinhos e Sucos de Uva do Planalto Norte Catarinense, ocorreu em 2022 a terceira edição do concurso. Ao total, foram inscritas e recebidas 55 amostras, sendo essas: 24 amostras de vinho tinto, 8 amostras de vinho rosé, 12 amostras de vinho branco e 11 amostras de suco uva, provenientes dos municípios de: Canoinhas, Bela Vista do Toldo, Irineópolis, Porto União, São Bento do Sul, Mafra, Papanduva, Itaiópolis, Monte Castelo e Rio Negrinho. Realizou-se, com auxílio de bolsistas voluntários, as análises físico-químicas das amostras para elaboração de laudo técnico a ser enviado aos produtores rurais. Com uma comissão julgadora composta por dez participantes, aconteceu a avaliação sensorial das amostras, pontuando as amostras de 0 a 100 pontos e, durante o V Encontro Regional da Cultura da Videira, ocorreu a divulgação e a premiação das três melhores amostras em cada categoria. Logo, faz-se necessário à sua realização anualmente do Concurso com objetivo de acompanhar a evolução da qualidade dos produtos elaborados, além da importância dessa ação para a formação dos discentes envolvidos no projeto.
Perfil da produção leiteira nos assentamentos rurais de Abelardo Luz-SC
Authors: Venâncio Amaral Diullay Cássia , Simioni Secchi Raissa , Rigo Goberte Taynara , Moreira Vinicius , Nunes Barbosa Cesa Nazaré , Castro Maciel Marluse , Braga Auro César , Rauber Lucio Pereira
Published: July 2024

O objetivo da pesquisa foi diagnosticar a situação das propriedades rurais nos assentamentos rurais por meio de uma pesquisa realizada com os produtores de assentamentos rurais na cidade de Abelardo Luz. Dentre as perguntas do questionário, estava a caracterização de propriedades quanto à localização, à área, à produção diária, ao tamanho do rebanho e quanto à compatibilidade como empreendimento rural familiar, à qualidade, à refrigeração e à estocagem do leite na propriedade, bem como ao controle sanitário do rebanho. Para a análise estatística, os dados foram coletados, tabulados e analisados através de técnicas de estatística descritiva. Observou-se que todos os produtores possuíam tanques próprios de refrigeração, sendo que 81,3 % consideraram-no em boa condição de uso, e possuíam equipamento para o controle de temperatura na estocagem do leite. Já no teste da caneca de fundo escuro, somente 56 % dos produtores adotam o uso desta técnica. Desta forma, é recomendada a capacitação periódica para os produtores rurais, com o intuito de informar, de orientar e de demonstrar novas tecnologias e práticas de manejo que adequem e que aperfeiçoem a produtividade dos rebanhos leiteiros.
Grupo de Estudos em Fruticultura de Clima Temperado e Viticultura do Planalto Norte Catarinense:
Authors: Tschoeke Steidel Otávio Frederico , Souza Farias Eduardo Virmond , Palinguer Rodrigo , Demetrio Kelly Eduarda , Wisniewski Caroline de Souza , Dybas Júlia Aime , Skraba Junior Bruno , Würz Douglas André
Published: July 2024

Dentro da Fruticultura, destaca-se para a região do Planalto Norte Catarinense a vitivinicultura, sendo uma alternativa de diversificação das propriedades rurais, com possibilidade de geração de emprego e renda, no entanto, essa é uma região caracterizado pelos pequenos agricultores familiares, não recebem assessoria técnica de forma efetiva. Em função da importância da Fruticultura no cenário agropecuário catarinense e do potencial de expansão dessa atividade na região do Planalto Norte Catarinense, realizou-se em 2023 o projeto de extensão ‘Grupo de Estudos em Fruticultura de Clima Temperado e Viticultura do Planalto Norte Catarinense – 2023/2. Dentre essas ações destacam-se: encontro mensais com estudantes para discussão de assuntos relacionados a Fruticultura e Viticultura; escrita e submissão de resumos em eventos científicos, participação em eventos técnicos na área da Fruticultura, palestras ministradas em eventos técnicos, capacitações realizadas com produtores rurais, gravação de vídeos e escrita de breves textos para publicação no Instagram do Grupo de Fruticultura. O presente projeto de extensão apresentou grande impacto para a região do Planalto Norte Catarinense, incentivando e estimulando a Fruticultura e Viticultura na região. Além disso, é uma oportunidade de grande relevância para a formação dos estudantes de Agronomia, que se aproximam do setor produtivo, além de aproximar os participantes de atividades vinculadas ao ensino, pesquisa e extensão.
Factors associated with stigma in adult women with uncomplicated urinary tract infections in China: A cross-sectional study
Authors: Wei Yaodi , Liu Hongyuan , Jiang Peng , Li Zhi , Zhao Yu , Wang Shiyu , Fan Siyu , Zhang Na , Liu Fengping , Feng Ninghan
Published: July 2024

Background
Uncomplicated urinary tract infections (uUTIs) pose significant risks to women’s physical and mental well-being, with the existence of social stigma further exacerbating the issue. Despite the prevalence and impact of this condition, there is a notable dearth of research exploring the specific stigma associated with uUTIs among women, particularly in regard to the influential factors. The current study seeks to address this gap in the literature, providing evidence of such stigma within the female population in China and identifying the key factors that contribute to its stigma.
Methods
A cross-sectional study was conducted between December 2022 and June 2023, during which samples were collected from 240 adult women with uncomplicated urinary tract infections from various healthcare facilities in Wuxi, China. General information questionnaires, the Chinese Version of the Social Impact Scale (range 24 to 96), the Multidimensional Perceived Social Support Scale, the Self-Rated Anxiety Scale and the Self-Rated Depression Scale were used. The influences associated with disease stigma were analyzed using a series of multiple regression models.
Results
The average stigma score of all participants was 2.71 ± 0.37, indicating a moderate level of shame. Multiple regression analyses revealed significant factors influencing stigma in women with uncomplicated urinary tract infections, including symptom duration, typical uncomplicated urinary tract infections symptoms, frequency of uncomplicated urinary tract infections episodes, disease knowledge, anxiety and depression levels, and social support.
Conclusion
Higher stigma levels in women with uncomplicated urinary tract infections correlated with increased anxiety and depression, reduced social support, frequent uncomplicated urinary tract infections episodes, longer symptom durations, limited disease knowledge, and typical symptoms such as urinary frequency and urgency. These findings stress the necessity of reducing stigma's impact on women's well-being with uncomplicated urinary tract infections.
Multi-approach assessment for predicting submerged discharge reduction factor in porous broad-crested weirs
Authors: Seif Yeganeh , Arman Ali , Rahmanshahi Mostafa
Published: July 2024

Environmentally friendly porous weirs have attracted the attention of researchers and engineers due to their favorable characteristics, surpassing solid weirs in terms of environmental impact, hydraulic performance, and stability. However, accurately estimating the submerged discharge coefficient for porous weirs is challenging due to the complex flow mechanisms involved, particularly under submerged conditions. The discharge under submerged conditions is typically expressed as a multiple of the free flow discharge, along with a coefficient representing the submerged discharge reduction factor (SDRF). This study aims to propose a novel artificial intelligence framework that incorporates metaheuristic techniques to predict SDRF for porous broad-crested weirs (PBCWs). The research utilized generalized normal distribution optimization (GNDO) to optimize the multilayer perceptron (MLP) model, enabling more precise predictions. The performance of the hybrid MLP-GNDO model was compared to that of an MLP, gene-expression programming (GEP), and standard nonlinear regression (SNR) models. A dataset comprising 966 observed experiments was employed to evaluate the proposed models. The results demonstrated that the hybrid MLP-GNDO model outperformed the MLP, GEP, and SR models, achieving a root mean square error of 0.021 and 0.022 and an R2 value of 0.964 and 0.954 for the training and test datasets, respectively. This model accurately predicted the train and test datasets with an average error rate of less than 2%. Regarding accuracy, the models ranked in the following order: MLP, GEP, and SNR.
Enhancing the Motor Learning: Clinical Pilates Training for Parkinson's Disease: Study Protocol for a Randomised Controlled Trial
Authors: Çoban Fahriye , Kaygısız Beliz Belgen
Published: July 2024

Background: The Parkinsonpilates is a clinical Pilates training designed to improve motor learning, postural stability, and gait, may be beneficial for individuals with Parkinson's disease (iwPD). The main objective of this randomised controlled trial (RCT) is to provide evidence for the acceptability of the Parkinsonpilates as a new approach and to investigate the clinical outcomes.
Methods: 30 iwPD will be recruited for this study and also, the participants have to be in Hoehn Yahr stage 2-3. The participants will be randomly assigned to the Parkinsonpilates Group(PP) and Conventional Physiotherapy(CP) Group. Also, they will be evaluated 4 times in a 6 months. According to the evaluation schedule, the first evaluation will be before starting treatment(T0), the second evaluation will be 6 weeks after treatment(T6), post-treatment evaluation which will be at the end of 12th week(T12) and the follow-up will be 12 weeks after treatment ends (T24). The evaluation of patients' physical and motor skills will utilize The Unified Parkinson's Disease Rating Scale (UPDRS) III subscale. To gauge functional mobility, we will administer the Timed Up and Go Test(TUG). Assessment of dynamic balance will be carried out with the Functional Reach Test(FRT), and evaluation of postural control and dynamic balance will be conducted using the Berg Balance Scale. Furthermore, the Gait and Balance Scale (GABS) will be employed to evaluate patients' gait, balance, and functional capacities. Additionally, the reaction time will be measured using the Nelson foot reaction test.
Discussion: Building upon our previous research, which underscored the potential efficacy of clinical Pilates in PD management, our aim is to highlight the potential long-term impacts of integrating motor learning principles into clinical Pilates interventions for PD patients. Through this study, we aim to underscore the significance of such an integrated approach in fostering sustained improvements in PD symptoms and overall well-being.
Trial Registration: This study has been registered at ClinicalTrials.gov as NCT05899426 (June,2023) under the name ‘The Motor Learning-based Clinical Pilates Rehabilitation Protocol for Patients with Parkinson's Disease’.
Predictor factor for growth and development status in cholestasis jaundice children, a cross sectional study
Authors: Seratin Fiha , Fadlyana Eddy , Ermaya Yudith Setiati
Published: July 2024

Background
Cholestasis jaundice refers to a condition where there is a decrease in bile secretion and flow, which can be categorized as either intrahepatic or extrahepatic. It is characterized by elevated levels of direct bilirubin, typically exceeding 1 mg/dL. This condition may lead to growth and developmental disorders in children. Screening for growth and development disorders can be measured by using WHO growth standard and Denver II tools. This research aims to investigate the factors predicting the growth and developmental status of children affected by cholestasis jaundice, employing WHO growth standards and the Denver II tools for analysis.
Methods
This study is a cross-sectional analysis involving 61 children aged 0–3 years diagnosed with cholestasis jaundice. The research was conducted at The Hasan Sadikin General Hospital gastrohepatology clinic between September and November 2023, utilizing both laboratory and imaging examinations. Sociodemographic and clinical data were obtained through direct interviews with parents or guardians. Body weight and height measurements were taken using weight scales and length boards or stadiometers. The developmental status of the children was assessed using the Denver II tools. Data analysis was performed using SPSS version 18.00.
Results
33 children with intrahepatic cholestasis and 28 extrahepatic cholestasis. Direct bilirubin levels > 5.263 mg/dL and H/LAZ ≤-2.08 SD are predictor factors for the growth and development status of children with cholestasis jaundice.
Conclusions
The findings from direct bilirubin testing and the H/LAZ measurements serve as potential indicators for assessing the growth and developmental status of children affected by cholestasis jaundice.
Positive response of barley to an indigenous arbuscular mycorrhizal fungal (AMF) inoculant is modulated by genotype and environment through changes in AMF root abundance and community structure
Authors: Marrassini Valentina , Ercoli Laura , Paredes Ana Vanessa Aguilar , Pellegrino Elisa
Published: July 2024

In barley cultivation, high use of mineral fertilisers in combination with low crop nutrient use efficiency results in severe environmental and economic issues. In this context, inoculants with indigenous arbuscular mycorrhizal fungi (AMF) could represent an efficient solution where intensive agriculture negatively impacted soil AM fungal abundance and diversity. However, since crop breeding and environment can strongly affect plant mycorrhizal response, in this work, we tested the agro-ecological effect of field inoculation with a indifìgenous AM fungal consortium on three varieties of barley for two years. In 2020, when soil was clay loam with very low P availability and no drought stress, Atomo and Concerto varieties positively responded to inoculation in terms of AM fungal traits, whereas in 2021, with silty clay loam soil, low P availability and drough stress, only Concerto was responsive. In 2020, inoculation promoted grain yield by 64% and 37% in Atomo and Concerto, and in 2021 by 78% and 134% in Concerto and Atlante. Multivariate analysis highlighted a strong effect of environment on barley productivity and a third-order significant interaction AMF, genotype and environment (65% and 7% of explained variance). Inoculation slightly modified AM fungal composition, it strongly modified, together with plant growth stage, the AM fungal community structures. A significant relationship between root AM fungal abundance and barley productivity was highlighted, with arbuscules as best predictor. Accordingly, changes in AM fungal root community structure and not in composition drove barley response and the main players were Glomus sp. VTX00342 and Septoglomus sp. VTX00064, putative members of the local AM inoculum. The general positive barley productivity outcome supports the use of indigenous AMF for building efficient and ecologically safe inoculants and their inclusion in sustainable agriculture. Nevertheless, the selection of genotypes with stable AM fungal response in specific climatic conditions is crucial in biofertilization programmes.
Surveillance for Schmallenberg Virus in Cattle
Authors: Santos Jana Kelly dos , Nascimento Sergio Alves , Silva Karla Patrícia Chaves , Medeiros Elizabeth Sampaio , MAIA RITA DE CASSIA CARVALHO , Junior José Wilton Pinheiro
Published: July 2024

The objective of this study was to conduct a serological investigation for Schmallenberg virus (SBV) infection in cattle raised in the State of Alagoas. A total of 460 samples obtained from the serum bank of the Agricultural Defense Agency of Alagoas (ADEAL) were analyzed. These samples originated from unvaccinated cattle of 100 properties spread across 99 municipalities in Alagoas, encompassing the three mesoregions: Agreste, Leste, and Sertão. Serological diagnosis was carried out utilizing commercial indirect and competitive Enzyme-Linked Immunosorbent Assay (ELISA) kits. Results indicated that 0.87% (4 out of 460) of samples yielded questionable results in the indirect ELISA (> 50.00% and ≤ 60.00% of the calculated percentage). Following further examination with competitive ELISA, only one sample was yielded positive. This highlights the necessity for reinforcing regional surveillance and control strategies concerning emerging pathogens. Furthermore, additional investigations incorporating viral isolation in both ruminants and vectors are imperative to conclusively confirm the circulation of the pathogenic agent. Such comprehensive studies are vital for enhancing our understanding of SBV dynamics and facilitating the development of targeted control measures.
Effects of long-term meditation on the expression of genes related to inflammation and their methylation status: A case-control study
Authors: Dasanayaka Nirodhi Namika , Sirisena Nirmala Dushyanthi , Samaranayake Nilakshi
Published: July 2024

Background:Despite established benefits for mental and physical well-being, the precise underlying molecular mechanisms of the effects of meditation remain unclear. This study explored the hypothesis that long-term meditation practice downregulates the expression of genes associated with stress-induced inflammation. The expression of selected inflammation-related genes and their promoter methylation status were compared between long-term meditators and controls.
Methods:Thirty experienced meditators and 30 age- and gender-matched non mediators participated in this case-control study. RNA and DNA were extracted from blood samples. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) with GAPDH normalization was used to measure the expression of eight inflammation-related genes (IFN-γ, IL-6, CCL-2, CCR-7, TNF-α, NF-κB, CXCL8, andCOX-2). Additionally, bisulfite-specific PCR and Sanger sequencing were performed to assess the methylation status of five of these genes (IL-6, TNF-α, IFN-γ, COX-2, and CXCL8) in their promoter regions.
Results: The mean age of participants was 43.83 ± 9.92 years, and 63.34% in each group were male. Compared to controls, meditators showed significantly lower relative gene expression for IFN-γ (Fold change (FC)=7,p=0.045), IL-6 (FC=3.6,p=0.045), TNF-α (FC=2.73,p=0.038), NF-ƘB(FC=3.2,p=0.045), CXCL8 (FC=3.3,p=0.047), and COX-2 (FC=9.5,p=0.013). Furthermore, meditators exhibited significantly higher promoter region methylation in IL-6 (p < 0.001) and CXCL8 (p = 0.001). The methylation level at specific CpG sites showed that four out of 16 sites in IL-6 and five out of twelve sites in CXCL-8 gene had significantly higher methylation in meditators. Although no significant difference in the overall methylation level in the promoter regions of TNF-α and IFN-γ genes were detected, two out of 12 sites and one out of 27 sites in the TNF-α and IFN-γ genes, respectively, showed significantly higher methylation in meditators.
Conclusion:These findings suggest that long-term meditation practice may contribute to reduced inflammation by downregulating the expression of specific inflammatory pathway genes and increasing their promoter methylation. Further research is needed to explore these potential mechanisms and their long-term health implications.
Effectiveness of the ‘Thinking Healthy Program’ to reduce antenatal depression in pregnant women in a tertiary care hospital: A quasi- experimental study in Pakistan
Authors: Ahsan Quratulain , Saleem Javeria , Malik Abid , Zakar Rubeena , Siddique Kashif , Naz Mahwish , Bukhari Gul Mehar Javaid , Fischer Florian
Published: July 2024

Background
In developing countries, the prevalence of postpartum depression can range from being comparable to that of developed nations to twice as high. The ‘Thinking Healthy Program’ (THP) is an evidence-based intervention specifically designed for addressing perinatal depression. This study aimed to evaluate the effectiveness of THP in reducing perinatal depression among pregnant women in Pakistan.
Methods
We recruited 220 pregnant women from the obstetrics and gynecology outpatient department of a tertiary care hospital in Lahore, Pakistan. Depression was screened using the Patient Health Questionnaire (PHQ-9), identifying 80 women (36%) with scores indicating depression (PHQ-9 score > 10). Of these, 22 consented to participate in the study. A quasi-experimental design was used to assess the impact of the THP intervention, targeting women aged 18–45 years in their 24–26 week of pregnancy. The intervention included fortnightly psychotherapy sessions aimed at modifying negative thinking patterns and behaviors, particularly in the context of developing mother-child relationships. The effectiveness of the THP sessions was measured using the Student’s t-test.
Results
A significant reduction in depression scores post-intervention (p < 0.05) demonstrated the intervention’s efficacy. Additional analysis of demographic characteristics also showed significant improvements.
Conclusion
This study provides evidence that the THP intervention is an effective, low-intensity psychotherapy treatment during the antenatal period, capable of preventing postpartum depression at clinical setting.
Community-based health education: A pilot module on maternal and child health for public health students in Pakistan
Authors: Zakar Rubeena , Tekian Ara , Zakar Nazoora Manal , Fischer Florian
Published: July 2024

Background Maternal and child health (MCH) plays a critical role in the development of nations, with the well-being of mothers and children being essential for societal progress. Despite efforts, Pakistan continues to face high maternal and child mortality rates. Recognizing the potential of universities in improving community health through outreach programs, this project aims to enhance the capabilities of the existing Center for Research in Maternal and Child Health within the Department of Public Health by developing a Community-Based Education module in MCH.Methods Led by a team with expertise in maternal and child health, medical education, and curriculum development, the module was created using the PARE framework (Preparation, Action, Reflection, and Evaluation) for community-based course planning. The module content development process entailed an extensive review of curricula from both Pakistani and international universities, alongside baseline surveys with community mothers, consultations with faculty members and health department officials, and assessments of student needs.Results The resulting 124-page module comprehensively addresses prevailing maternal and child health challenges in Pakistan. Structured into two main chapters on 1) maternal health and 2) child health, each chapter is further divided into six sub-chapters. It covers nutrition, health conditions, healthcare service utilization, sanitation, and hygiene issues relevant to MCH.Conclusions Moving forward, the project will embark on faculty and student training sessions to facilitate module implementation in community settings, followed by a year-long deployment within target communities. Evaluation mechanisms will gauge module effectiveness through pre- and post-test analyses of community and student data. This endeavor heralds a pioneering initiative in Pakistan, epitomizing the integration of community-based education and university partnerships to enhance the educational experience of public health students. Plans are underway to expand this initiative to other universities across Punjab province, ensuring its sustainability and scalability for broader community impact
Preferences trust interaction of nurses and parents as mediating variables between knowledge and shared decision making in the care of newborns in Hospitals
Authors: Rohmah Nikmatur , Utami Resti , Kholifah Siti
Published: July 2024

Background Knowledge is an important element in making decisions. Making decisions without having adequate knowledge will potentially lead to decision conflicts. This study aimed to analyze of preferences, trust, and interactions between nurses and parents as mediating between knowledge and shared decision-making in the care of newborns in hospitals.
Methods The research design was cross-sectional. The population was all parents of newborns hospitalized in Regional Hospital Jember Regency, East Java, Indonesia March–June 2021. The sampling methode was selected by simple random sampling. The required participants are 92. Data collection by questionnaires compiled by researchers, and data analysis by Partial Least Square.
Results: The results showed that knowledge (T-statistics=4.464; p=0.000) influenced shared decision making through preferences (T-statistics=3.600; p=0.000), trust (T-statistics=6.760; p=0.000), and nurse interactions and parents (T-statistic=9,160; p=0,000). The interaction of nurses and parents proved to have the strongest influence on shared decision-making. This study recommends that nurses increase interaction with parents. Nurses can maximize the role of parents in together decision-making on the care of newborns in the hospital.
Conclusion The knowledge influenced shared decision-making of newborn care through the preferences, trust, and interactions of nurses and parents. This study recommends that nurses should increase interaction with parents. Nurses can maximize the role of parents in shared decision-making on the care of newborns in the hospital.
Retinal morphology across the menstrual cycle: insights from the UK Biobank
Authors: Reis Ana Paula Ribeiro , Ioannidou Estelle , Wagner Siegfried , Struyven Robbert , Sun Zihan , Foster Paul , Khawaja Anthony P , Petzold Axel , Sivaprasad Sobha , Pontikos Nikolas , Keane Pearse , Balaskas Konstantinos , Greco Elena , Iliodromiti Stamatina , Patel Praveen J
Published: July 2024

Oestradiol and progesterone levels are higher in menstruating women than men of the same age, and their receptors are present in their neurosensory retina and retinal pigment epithelium. However, the impact of this hormonal environment on retinal physiology in women remains unclear. Using self-reported menstrual cycle phases as a surrogate for fluctuating hormonal levels, we investigated associations with retinovascular indices on colour fundus photograph and retinal thickness in optical coherence tomography across regularly menstruating women in the UK Biobank. We found no differences in retinal thickness across the cycle; however, vessel density, arteriolar and venular, and fractal dimension were higher in the luteal phase than follicular. The calibre of the central retinal vessels did not differ. This study suggests that the menstrual cycle phase might be associated with retinal microvasculature density in non-invasive imaging. It raises awareness for this understudied area, providing insights into neuroscience fields and epidemiological studies.
Predicting risk factors for postoperative enterostenosis in neonates with necrotizing enterocolitis：development and assessment of a predictive nomogram
Authors: Chen Yang , Zhou Ling , Liao Qianghui , Xiao Dong , Zhu Ledao , Yao Jinlong , Liu Jiashu , Zhang Xuling , Ma Xiaopeng , Ren Feng , Wang Zhiyong
Published: July 2024

Objective: The aim of this study was to develop and validate an enterostenosis prediction model for postoperative newborns with neonatal necrotizing enterocolitis (NEC).
Methods: Clinical information was collected on neonates who had undergone anastomosis or enterostomy because of NEC. The least absolute shrinkage and selection operator regression was applied to identify risk factors included in the model for postoperative enterostenosis. Multivariate logistic regression analysis was used to develop a predicting model regression based on the selected variables. Then internal validation was assessed using the bootstrapping validation. The accuracy and applicability of the model are assessed by C-index, calibration and decision curve.
Results: Predictors incorporated into the model were weight on admission, hematochezia, duration of abnormal C-reactive protein, lactate, intestinal peristalsis vanish, operation methods and duration of surgery. The regression equation was logit (P) = -0.001X1+1.566X2+0.185X3+0.304X4+1.34X5-2.932X6+0.015X7-3.193, where X1 was weight on admission (g), X2 was hematochezia (yes=1, no=0), X3 was duration of abnormal C-reactive protein (days), X4 was lactate (mmol/L), X5 was intestinal peristalsis vanish (yes=1, no=0), X6 was primary anastomosis (yes=1, no=0), X7 was duration of surgery (min). The model displayed good discrimination with a C-index of 0.879(0.827,0.932) by random sampling for 1000 times. The calibration curve excluded the overfitting performance, and the decision curve confirmed the clinical application capacity of the model.
Conclusion: This nomogram of enterostenosis incorporating the use of weight on admission, hematochezia, duration of abnormal C-reactive protein, lactate, intestinal peristalsis vanish, operation methods and duration of surgery could be conveniently used to facilitate the enterostenosis risk prediction in postoperative NEC patients.
Pan-Cancer Analysis Reveals Prognostic Potential of ANGPTL2 and Its Implications in Tumor Microenvironment
Authors: Ke Junyu , He Zhikun , Duan Yilin , Zhu Yaqing , Xu Yingjian , Zhou Hengli , Lei Jie , Wang Haiyan , Shan Zejun , Zhang Yingying , Wei Yating , Zeng Yuyin , Zhang Jiali , Lu Yao , Wu Yongqiang
Published: July 2024

Background
Angiopoietin-like protein 2(ANGPTL2)stimulates inflammatory and angiogenic pathways,promoting tumor growth and metastasis.However,research on the prognostic significance,immune infiltration,expression patterns,and underlying mechanisms of ANGPTL2 in various malignancies is sparse.
Methods
We used different online platforms and datasets to conduct a comprehensive investigation of ANGPTL2 in various human malignancies,including mutation status,methylation levels,and expression profiles.Our study looked at the impact of ANGPTL2 on survival prognosis in various tumour types,its correlation with immune checkpoint genes,immune and stromal scores in tumours,its functional relevance in different cancer types,associated signalling pathways and biological functions,validation of its expression in gastric cancer,and its effects on cell proliferation,migration,and invasion using cell models.
Results
ANGPTL2 mutations were predominantly missense and truncation.In 31 tumour types,ANGPTL2 expression differed significantly from normal tissue(P < 0.05).Survival analysis revealed that the highest ANGPTL2 expression had worst results.Notably,patients with reduced ANGPTL2 expression showed increased overall survival(OS)in gastric adenocarcinoma,lung cancer and bladder cancer(P < 0.05).Immune infiltration analysis showed positive correlations between ANGPTL2 expression and immune infiltration in 36 tumour types(P < 0.05).Furthermore,ANGPTL2 was found to be positively associated with immune checkpoint genes in most cancers(P < 0.05).In uveal melanoma and retinoblastoma,ANGPTL2 expression was positively correlated with angiogenesis,inflammation,stemness,but negatively correlated with DNA damage,DNA repair,and cell cycle.In the AngPTL2-overexpressed cell model,the proliferation,migration and invasion of GES-1 cells were significantly enhanced.
Conclusions
Increased ANGPTL2 expression positively correlates with immune cell infiltration,immune checkpoint genes and immune scores in most tumours.In addition,ANGPTL2 has been linked to significant migration and invasion capabilities in clinical samples and in vitro experiments.
Isolation and characterization of bacteriophages from sewerage water targeting methicillin resistance S. aureus in burn patients
Authors: Zafar Nishat , Aslam Aamir , Rahman Sajjad Ur , Saqib Muhammad
Published: July 2024

The spectrum of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) ranges from minor to potentially life-threatening. Due to its increased antibiotic resistance, treatment failures are frequent, necessitating novel eradication approaches. In this study, we aimed to isolate MRSA from burn patients, ascertain its antibiogram pattern, and isolate and characterize bacteriophages from sewerage water targeting MRSA. A total of 70 samples were collected from burn patients, and MRSA was identified and characterized using various biochemical and molecular tests, alongside antibiotic sensitivity profiling. MRSA prevalence was found to be 28.6%, with biochemical and molecular analyses confirming its presence. Antibiotic susceptibility testing revealed that 94% of isolates were sensitive to tobramycin and gentamycin, while lowest sensitivity (2%) was observed against vancomycin. Using the soft agar overlay method, three bacteriophages (Phage-1, Phage-2, and Phage-3) were successfully isolated from sewerage water. Among all the phages, Phage-3 demonstrated a broader host range. Furthermore, Phage-3 displayed optimal activity within a pH range of 6–8 and at temperatures between 20–40°C. Phage-3 indicated a rapid decrease in adsorption time within 0–5 minutes, while its one-step growth curve revealed a latent phase lasting up to 30 minutes, followed by a significant increase in titer from 30–50 minutes.
Protocol paper for an implementation science approach to promoting colorectal cancer screening in Federally Qualified Health Center clinics: A stepped-wedge, multilevel intervention trial.
Authors: Montoya CPH CHES MPH Samantha M. , Olaore CPH MPH MBChB Pelumi , Bastardo-Acosta  , Abdulla MA Rania , Schell Michael J. , Hidalgo Allan , Turner BSN RN Barbara , Rider DO Monica , Kishun-Jit Nirmala , Joshua Ashlon , Pollard Jennifer , Friedman Mark , Christy Shannon M. , Meade  , Gwede
Published: July 2024

Background
Colorectal cancer is the third leading cause of cancer-related deaths in the United States. Despite the Healthy People 2030 goal of 70.5%, colorectal cancer (CRC) screening rates in Federally Qualified Health Centers (FQHCs) are suboptimal at about 40%. The Colorectal Cancer Awareness, Research, Education and Screening-Rural Expansion, Access, and Capacity for Health (CARES-REACH) study seeks to address this disparity and accelerate the adoption and utilization of effective, evidence-based CRC screening practices. This paper describes the CARES-REACH study design and implementation methods.
Methods
Informed by a community-based participatory research (CBPR) framework and enriched by implementation science approaches, CARES-REACH features a stepped wedge design with extension for maintenance to support an implementation strategy focused on multiple levels: organizational, provider, and patient levels that entail processes to boost initial and repeat screening among average risk and age-eligible adults. This multilevel study entails the implementation of a core set of evidence-based interventions (EBIs) that include low literacy patient education (English, Spanish, and Haitian Creole language); provider education, system-wide electronic medical record (EMR) tools including provider prompts and patient reminders, FIT (fecal immunochemical test) kit distribution, plus an organization-wide cancer control champion who motivates providers, coaches and navigates patients, and monitors system-wide CRC screening activities.
Trial Registration
NCT04464668.
Role of pulse oximetry for early detection of critical congenital heart disease among the neonates at hospitals affiliated with shiraz university of medical sciences: A pilot study.
Authors: Bahrami Reza , Rooinpeykar Mitra , Naghshzan Amir , Moradi Ali , Bahrami Mohammad , Razavinejad Seyyed Mostajab , Rezaei Mehrdad
Published: July 2024

Background and Objective:
Congenital heart disease (CHD) is a structural anomaly of the heart that manifests before birth, and it is one of the most prevalent congenital disabilities. The presentations of CHD are heterogeneous and depend on the defect type and age of the neonate. The physical examination and pulse oximetry provide a high level of accuracy, exhibiting a sensitivity of 92% and a specificity of 98% when used together. Some studies showed that pulse oximetry has an influential role in the screening of CHD. However, there are controversial cutoff levels of oxygen saturation as a Reliable screening. This study aims to evaluate the acceptable cutoff of oxygen saturation based on previous guidelines as the primary goal and the prediction of challenges in the screening program of neonates based on the Newborn Health Program.
Method
This prospective cohort study from September 2021 to June 2022 on 372 neonates with full inclusion criteria and follow-up. The study focused on newborns admitted to the Neonatal Intensive Care Unit (NICU) at Zainabiyeh Hospital, the tertiary referral NICU center south of Iran. The screening was conducted by qualified medical practitioners using pulse oximetry after the first day of admission. Readings above 95.5% were considered negative, while those below 90% were deemed positive. The results were 90% − 95.5%; re-evaluate after one hour. In the re-evaluation, if the result was above 95.5%, it was considered negative; if it was below 95.5%, it was considered positive. Echocardiography was conducted within 48 hours for all infants with a positive pulse oximetry result. A bedside echocardiogram was performed before discharge for all neonates. Finally, the echocardiography and pulse oximetry results were compared to evaluate the negative and positive predictive value of pulse oximetry results and cutoff.
Results
Among 372 neonates, 222 (59%) had a normal echocardiogram, and 150 (41%) had an abnormal echocardiogram. Among neonates with abnormal echocardiography, 96% had acyanotic disease, and more than 50% of babies whose oxygen saturation was less than 95.5% had abnormal echocardiography. Pulse oximetry with a cutoff of 95.5% had 100% sensitivity and a specificity of 84–87.5% for the diagnosis of CHD. More than 69% of babies with saturation less than 95.5% in all four limbs had an abnormal echocardiogram.
Conclusion
Pulse oximetry, as the screening tool, can help early detection of neonates with CHD and is also the cost-benefit method in areas lacking tertiary centers for neonatal echocardiography.
Complete resolution of non-tuberculous mycobacterial pulmonary nodule following cryobiopsy: he first case report
Authors: Han Sung Joon , Park Dongil
Published: July 2024

Non-tuberculous mycobacterial (NTM) lung disease encompasses a diverse group of pulmonary conditions, present significant diagnostic challenges, especially in radiological interpretation. The disease can mimic lung cancer, tuberculosis, and other bronchopulmonary disorders, complicating accurate diagnosis.
Case Presentation: A 46-year-old healthy woman was incidentally found to have a 1.3-cm pulmonary nodule in the left anterior basal segment during a routine health examination, with no symptoms or significant medical history. Initial CT imaging raised suspicions of T1a lung cancer. Subsequent endobronchial ultrasound transbronchial lung biopsy (EBUS-TBLB) and transbronchial lung cryobiopsy (TBLC) revealed granulomatous inflammation. Tests for tuberculosis and NTM were negative. Following the biopsies, chest X-rays showed an enlarged shadow at the lesion, suggesting necrosis after cryobiopsy. The patient was treated with moxifloxacin, leading to symptom improvement. A final diagnosis of NTM infection, specifically Mycobacterium avium, was confirmed from bronchoalveolar lavage (BAL) fluid. At four months post-biopsy, a chest CT scan showed complete resolution of the nodule.
Conclusion: NTM nodules may undergo necrosis and resolution due to the ablation effect of cryobiopsy, suggesting cryoablation as a potential option for inoperable localized NTM disease.
Enhanced Precision in Motorcycle Helmet Detection: YOLOv5 and Darknet Approach
Authors: Sarmah Ranjan , Lahon Pranjit , Ahmed Tazliqutddin
Published: July 2024

In India, helmets symbolize safety and civic responsibility, bearing cultural significance. However, a 22% increase in accidents and a 17.5% rise in fatalities in 2022-23 underscore the critical importance of helmet compliance beyond legal mandates. Non-compliance not only elevates the risk of injuries and fatalities but also entails legal consequences. Notably, 47,000 Indians died in 2021 due to not wearing helmets, emphasizing the pivotal role of helmet usage in road safety. This research focuses on improving motorcycle helmet detection to ensure compliance and reduce the risk of fatal head injuries for riders, extending its impact beyond geographical limits. While our dataset predominantly draws from Sivasagar, a district in Assam, India, the scope of our research is universally applicable. We employed a comprehensive methodology, comprising data collection, preprocessing, and YOLOv5 model training using the Darknet framework, testing, and evaluation. Analysis of the original YOLOv5 algorithm's performance using Precision-Recall (PR) curves resulted in mAP values of 85.9% for helmets, 88.1% for human heads, and an average of 87%. Subsequently, the proposed YOLOv5 algorithm, achieving mAP values of 93% for helmets, 96.8% for human heads, and a remarkable 94.9% average mAP, demonstrated significant improvements. Comparison revealed a consistent 7–8.5% higher mAP for helmet and human head detection, underscoring the efficacy of the proposed approach in improving detection capabilities. This research contributes to the broader field of computer vision and its practical applications, particularly in enhancing road safety and averting head injuries among riders, irrespective of their location.
Activation of a GPCR, ORL1 receptor: A novel therapy to prevent heart failure progression
Authors: Pathan Saliha , Pugazenthi Aarthi , Dixon Beverly REA , Wensel Theodore G , Rosengart Todd K , Mathison Megumi
Published: July 2024

Purpose
The number of ischemic heart failure (HF) patients is growing dramatically worldwide. However, there are at present no preventive treatments for HF. Our previous study showed that Gata4 overexpression improved cardiac function after myocardial infarction in the rat heart. We also found that Gata4 overexpression significantly increased a Pnoc gene expression, an endogenous ligand for cell membrane receptor, ORL1. We hypothesized that an activation of ORL1 receptor would suppress HF in a rat ischemic heart model.
Method
Adult Sprague Dawley rats (8 weeks old, 6 males and 6 females) underwent left anterior descending coronary artery ligation. Three weeks later, normal saline or MCOPPB (ORL1 activator, 2.5mg/kg/day) intraperitoneal injection was started, and continued 5 days a week, for 3 months. Echocardiography was performed six times, pre-operative, 3 days after coronary artery ligation, pre-MCOPPB or saline injection, and 1, 2, and 3 months after saline or MCOPPB injection started. Animals were euthanized after 3 months follow up and the heart was harvested for histological analysis.
Results
ORL1 activator, MCOPPB, significantly improved cardiac function after myocardial infarction in rat (Ejection fraction, MCOPPB vs saline at euthanasia, 67 ± 3 vs 43 ± 2, p < 0.001). MCOPPB also decreased fibrosis and induced angiogenesis.
Conclusion
ORL1 activator, MCOPPB, may be a novel treatment for preventing HF progression.