bluuebunny/crossref_metadata_2025 huggingface dataset:
KONSEPSI MAHRAM SEBAB PERZINAAN DALAM HUKUM ISLAM
Authors: Nurcholis Moch
Published: February 2022

Jurisprudence books divide the concept of marriage into two groups, First, the group that is permissible for marriage. Second, the group that is not allowed or forbidden to be married (mah}ram). The concept is based on the presence or absence of blood relations between the bride and groom. So in the fiqh study mah}ram is divided into three in general namely mah}ram bi nasab, mah}ram bi mus}aharah and mah} ram bi roudlo`. However, there is a relationship where the scholars disagree, namely whether a male adulterer has an affair with a daughter resulting from adultery ?. This is interesting to study considering that both fiqh books and laws in Indonesia have stated that children born outside a legal marriage (both adultery and siri) only have a nasab relationship (mah}ram) with the mother and family of the mother . To answer the problem of whether a male adulterer has a relationship with a daughter of adultery and may or may not get married, the writer will examine the criteria of mah}ram contained in the books of fiqh. After obtaining data about the forms of security, it is then analyzed using the legal excavation method in the form of qiyas. In the qiyas methodology there are stages to finding `illat law. The technique of determining `illat can be done by using two common methods, namely using the theorem naqli and` aqli. So that the 'illat law emerges 'illat similarity between cells of genetic material contained in sperm and milk so as to make both of them a major influence on the mental and physical health of a child born or breastfed that is inherited from the genetic cells of his parents. From these findings, it can be concluded that the marriage between biological father and daughter resulting from adultery is prohibited.
EKONOMSKO-IMOVINSKI KRIMINAL U ISLAMU
Authors: Topoljak Sulejman
Published: February 2022

Imovina i ekonomija su osnovne potrebe svakog pojedinca, zajednice, društva i države i njihova kičma. Stoga je islam imovinu svrstao u pet univerzalnih vrijednosti, zaštitio ih svojim normama i propisima i odredio sankcije protiv svakog onoga koji ih na bilo koji način ugrožava, devalvira i uništava, jer se njihovom zaštitom štiti pojedinac, porodica, društvo i javni red u državi pa i sama država.Imovina i ekonomija u svakom društvu i državi imaju status krvotoka u živom organizmu – tijelu. Da bi tijelo bilo zdravo i moglo vršiti svoju osnovnu funkciju neophodno je da ima zdrav krvotok. Zdrav krvotok podrazumijeva zdrave i čiste vene, arterije i kapilare kako bi krv mogla dopirati i donositi kisik i hranu do svake ćelije i kapilara u organizma. Bilo koje suženje ili začepljenje u navedenim provodnicima će imati neželjene posljedice koje će se odraziti na normalno funkcionisanje tijela, a možda uzrokovati i njegovu smrt. Istom logikom i analogijom treba posmatrati i imovinu i ekonomiju u jednom društvu i državi. Ukoliko imovina ne bude dopirala zdravim i nezačepljenim putevima do svakog građanina u društvu i zajednici, nego se bude gomilala u rukama pojedinaca ili privilegovanih grupacija i oligarhija, krvotok takva društva i države će postati bolestan i začepljen, pa takva država i društvo neće moći normalno funkcionisati i onda je samo pitanje dana kada će dobiti srčani ili moždani udar i ostati osakaćeno, potpuno paralisano ili uništeno.Odatle je i cilj ove studije da istraži stav islama po pitanju ekonomsko-imovinskog kriminala i preventivne mjere koje je propisao kako bi taj krvotok zaštitio i očuvao zbog njegove sudbonosne i nezaobilazne važnosti kako u životu pojedinca tako i u opstanku svakog društva i države. Savremena poremećenost imovinsko-ekonomskog sistema, tj. ekonomskog krvotoka na makro i mikro planu potvrđuje važnost njegove zaštite i zdravlja. U protivnom, posljedice njegove bolesti i začepljenja ispaštat će, na globalnom nivou, skoro svaka država i svaki stanovnik ove planete. To potvrđuje današnje ekonomsko stanje u svijetu i sve posljedice koje je ono uzrokovao i donijelo.U radu će biti pobrojane najvažnije vrste tog kriminala, sankcije koje su propisane, blagodati koje se realizuju od primjene tih sankcija, te preventivno-reformatorski program koji je islam propisao za zaštitu ekonomije i njene revitalizacije.
Сезонная динамика и пространственное распределение концентраций антропогенных загрязнителей в воздухе г. Воронеж
Authors: Акимов Леонид Мусамудинович , Акимов Евгений Леонидович
Published: February 2022

Загрязнение атмосферного воздуха крупных городов является фактором окружающей среды, который обязательно должен учитываться при планировании хозяйственной деятельности, вследствие негативного воздействия на здоровье горожан. Решение проблемы оценки загрязнения воздуха в городах является многофакторной задачей, включающей учёт как антропогенной, так и природной составляющих данного процесса. В отношении г. Воронеж недостаточно научных данных, характеризующих опасность загрязнения воздушного бассейна химическими веществами, воздействующими на здоровье человека в различные сезоны года. В связи с этим авторами проведена оценка распределения концентраций поллютантов, том числе канцерогенных веществ, на территории Воронежа по данным наблюдательных постов за 2015–2019 гг. Установлены сезонные колебания концентраций поллютантов, характерные для разных функциональных зон города, в соответствии с пространственным расположением постов наблюдения за загрязнением атмосферы. 
Исследование выполнено при финансовой поддержке Российского научного фонда, проект № 20-17-00172.
Nonlinear cooperative transfer of atomic energy in the vacuum field of the cavity
Authors:   Institute of Applied Physics, Republic of Moldova, Pislari Tatiana
Published: February 2022

This paper researches the nonlinear cooperative transfer of atomic energy in the vacuum field of the cavity. Many scientists are concerned about a more detailed study of the cooperation interactions between different subsystems of quantum processes. Based on the theory of resonant interaction with two photons, between two active dipole atoms and a forbidden dipole in resonance with two photons, the author examines for the first time the resonance effect in two ways of the cavity. In some situations, the so-called quantum inseparability needs a new redefinition in order to describe the process that occurs between the photons belonging to these two modes of the cavity. In such a situation, it is better to study the quantum properties of collective modes arising from nonlinear interactions between traditional modes of the electromagnetic field cavity.
Pandemic crisis, an incentive for the modernization of moldovan society
Authors:   Moldova State University, Ciobanu Rodica
Published: February 2022

The social order and stability, security and well-being have become essential in the context of the pandemic crisis, highlighting many social and human issues. This article, focusing on the identification of governance mechanisms for the protection of human rights, emphasizes the weaknesses shaped by the pandemic crisis and argues in favor of the need to modernize the Moldovan society. With the assessment of the social-human impact of the pandemic as main objective, the theoretical-methodological framework of synergetics has been used, enabling to deal with the problem within the conceptual, functional, and operational frameworks.
The state of conservation of two copies of the Book of Hours (Ceaslov) printed in Dubasari (1794), found at Diocesan Museum in Husi
Authors:   Stefan cel Mare University of Suceava, Romania, Cimpianu Cristina Maria
Published: February 2022

Mihail Strelbitchi, bookbinder, refined engraver, and master printer, dominates the Moldovan typographic art from the 18th century. Among those several dozen works to which he contributed throughout his life, either as an engraver or as a printer, some are printed outside the borders of Moldova, respectively in Dubasari and Movilau. Book of Hours (Ceaslov) printed in Dubasari in 1794, where Strelbitchi settled his printing house for a short time, is a book in which he spreads countless elements of his graphic art: ornate letters, frontispieces, vignettes, and engravings bearing his signature. The Diocesan Museum in Husi has in its rich old book inventory two copies of Book of Hours (Ceaslov) printed at Dubasari. They are in a relatively good state of preservation, being kept almost entirely. No volume contains, however, the title page. The book is printed in Romanian, with Cyrillic characters. Both volumes are bound in brown leather, wooden boards, and metal locks, the leather being damaged The volumes lack support marks, having traces of a xylophagous attack. Some sheets are detached from the spine, which led to their embrittlement. All these degradations but also the value of the books themselves impose the need to restore these values of the Romanian typographic art.
Jazz improvisation as a phenomenon of music art
Authors:   Academy of Music, Theater and Fine Arts, Republic of Moldova, Dasevschii Veaceslav
Published: February 2022

This article examines a series of theoretical issues of jazz improvisation. The author analyzes various definitions and emphasizes the main features of jazz improvisation, reveals a number of ways of processing jazz standards. A special aspect represents the character of dialogue proper to this type of musical creation, the typology of improvisation and the relationship between improvisation and composition.
Jazz trumpet: some aspects of big band interpretation technique
Authors:   Academy of Music, Theater and Fine Arts, Republic of Moldova, Haruta Petru
Published: February 2022

The jazz trumpet has a well-pronounced specifics that is performed in the solo, ensemble and orchestral interpretive practice. A sound rich in nuances, various technical and expressive options, diverse procedures for sound emission, articulations, special ornaments – all this gives the trumpet an irreplaceable role in jazz music. The article examines the main aspects of jazz trumpet playing technique in a big band.
Rustic and urban in the creation of Florentin Leancă
Authors:   Moldova State University, Procop Natalia
Published: February 2022

Florentin Leancă is part of the generation of visual artists, representatives of the national school of painting. The activity of the artist evolved from abstract compositions to urban landscapes with impressionistic shade and stylized decorative creations. Many of his works are made in the technique of hot handkerchief and oil painting Moreover. One of his relevant themes is the old Chisinau represented by shades of gray. Lately he has been making pieces with popular motives inspired by the art of carpeting.
Mannheim offsets of ruled surfaces under the 1-parameter motions
Authors: Orbay Keziban , Sahin Tevfik
Published: February 2022

In this study, the situation of Mannheim offsets of ruled surfaces under the 1-parameter motions is investigated. Firstly, relationships between geodesic Frenet trihedrons of Mannheim offsets of ruled surfaces are obtained and the relationship between the curvatures of the surface pairs is examined. Also, change of integral invariants the surface pairs under the 1-parameter motions is studied. Finally, the relevant example is given for every Mannheim offsets of ruled surfaces.
Principal’s Supervision in Improving Teacher’s Performance
Authors: Gusmiyati Gusmiyati , Lian Bukman , Fitria Happy
Published: February 2022

This study determined the supervision of school principals and teacher performance. This research was conducted in 18 Public Elementary Schools in Gelumbang. The research method used in this study was qualitative method with a descriptive approach. Data were collectied using interviews, observation, documentation, questionnaires, and literature review. The results of the study stated that the supervision process was carried out by the principal through several stages, namely 1) planning the supervision activities; 2) implementation of supervision; 3) feedback the results of supervision; 4) follow up on supervision results. Based on the results of the supervision before the follow-up, it was found that more than 50% of the 18 Elementary School teachers in Gelumbang were not yet both categories in preparing the administration of learning devices. After giving feedback and the results of the teacher supervision follow-up assessment conducted by the school principal, 40% of teachers in the excellent category and 60% of teachers in the quite good category, thus the results of the supervision can improve the performance of teachers in SD Negeri 18 Gelumbang. The paper contributes to more give attention of supervision, and the the teacher’s performance will be improved.
The Influence of School Library Utilization and Reading Interest on Student Achievement
Authors: Shintia Dheby , Arafat Yasir , Setiawan Andi Arif
Published: February 2022

This study aimed at determining influence of using the school library and reading interest on student achievement fourth grade students of SD 04 OKU partially and simultaneously. This is a quantitative research with sampling using all class IV totaling 105 students. The variabels studied were the use of the school library (X1), reading interest (X2) and learning achievement (Y). Methods of data collection using a questionnaire. Data analysis using validity and reliability tests using the SPSS 22 for windows program. The results showed that there was an influence between the influences of the use of the school library on student achievement. This paper recommends to more focus on library and reading interest of students where school would have good students’ achievement.
The Effect of Teacher Performance and Learning Media on Learning Outcomes of Elementary School Students
Authors: Angraini Septa , Fitria Happy , Setiawan Andi Arif
Published: February 2022

This study aimed at determining the effect of teacher performance and learning media partially or simultaneously on student learning outcomes in SD District of East Baturaja. This research was a qualitative with sampling using random sampling technique. The study population amounted to 273 with a study sample of 108 people. The variables studied were teacher performance (X1), learning media (X2) and learning outcomes (Y). The data collection method used a questionnaire on the scale of teacher performance, the scale of learning media and student learning outcomes. The validity test was carried out with the help of a computer program SPSS 22 for windows. Reliability test using Cronbach's alpha technique, obtained p = 0, 986 for teacher performance variables and p = 0.987 for learning media variables. The data analysis technique is descriptive and inferential statistics with SPSS 22 for windows program. The results showed that there was an influence between teacher performance and learning media on student learning outcomes.
The Effect of Principal Leadership and Teacher Performance Toward Student Achievement
Authors: Mayasari Intan , Arafat Yasir , Setiawan Andi Arif
Published: February 2022

This study determined the effect of principal leadership and teacher performance partially and simultaneously on student achievement. The research method is ex post facto with a total population of 53 teachers for the study sampling using total sampling so that the research sample is the same as the population, which is 53 respondents. Data collection techniques using documentation and questionnaires. The data analysis technique used the t-test and the f-test. The results of this study can be concluded that there is an influence of the principal's leadership and teacher performance partially and simultaneously on student achievement at Junior High School 02 Ogan Komering Ulu.
The Effect of Leadership Effectiveness and Interpersonal Communication on Teacher Job Satisfaction
Authors: Jahro Listi , Harapan Edi , Tahrun Tahrun
Published: February 2022

The purpose of this ex post facto correlational study is to investigate the impact of leadership effectiveness and interpersonal communication on teacher job satisfaction at SMA Sub Rayon III Prabumulih City. A questionnaire was utilized as the study tool. Inferential statistics, such as the basic linear correlation test, multiple linear regression, t-test, and F-test, were used to assess the data. The findings revealed a substantial relationship between leadership effectiveness and interpersonal communication and teacher job satisfaction at SMA Sub Rayon III Prabumulih. This research assists the principal in establishing effective communication in the school environment in order to achieve teacher job satisfaction.
Improving the Quality of Learning through Teacher’s Guidance
Authors: Fitriana Fitriana , Harapan Edi , Kesumawati Nila
Published: February 2022

This study identified teacher teaching development as a means of improving the quality of learning at SD Negeri 15 Betung. The school served as the site for this study. This is a qualitative in which data is gathered through interviews, observation, and documentation. According to the results, teacher teaching development as an effort to improve the quality of learning at SD Negeri 15 Betung could be said good the ability of teachers to manage classes in terms of lesson plan and learning implementation; and the ability of the teacher to manage classes in terms of the teacher's activities opening and closing lessons. The teacher's competence handle the class means the teacher's activities in delivering reinforcement.
Preliminary results of the KAP study (knowledge, attitudes and practices) of doctors about the management of major cognitive disorders in the Republic of Moldova
Authors:   Diomid Gherman Institute of Neurology and Neurosurgery, Republic of Moldova, Grosu Oxana , Carausu Ghenadie ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Moldovanu Ion ,   Diomid Gherman Institute of Neurology and Neurosurgery, Republic of Moldova, Rotaru Lilia ,   Diomid Gherman Institute of Neurology and Neurosurgery, Republic of Moldova
Published: February 2022

Managing a patient with cognitive impairment is a challenge. Barriers are identified and doctors have different attitudes and practices on this subject. The purpose of the research - the analysis of doctors’ knowledge, attitudes, and practices regarding the management of dementia in the Republic of Moldova. Material and method: An online survey of neurologists, psychiatrists, family doctors, and psychologists. The questionnaire included 24 questions, average completion time - 15 minutes. The first 3 months of the survey were analyzed. Results: 122 questionnaires were validated, 45.9% neurologists, 25.4% psychiatrists, 13.1% family doctors, 9% psychologists answered. Among the problems are mentioned the lack of social services (54.1%), the lack of guidelines (50.8%), the lack of interdisciplinary collaboration (47.5%), problems in communicating with the patient (45.9%), difficulties in establishing the diagnosis (36.1%), in communication with relatives and caregiver (30.3%), in the treatment of comorbidities (29.5%), in the elaboration of the treatment plan (28.7%) and 0.8% - financial. A part of the respondents (38.5%) consider that these patients consume time, emotions, and resources, and 13.9% mention that they are a burden to the health system. Conclusion: In order to improve the knowledge, attitude, and practices of physicians involved in the management of patients with cognitive impairment, it is imperative to develop and implement a national program for cognitive impairment.
Drug treatment in improving the results and reducing the complications of endoscopic transurethral surgery in chronic non-bacterial sclerosis of prostate
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Colta Artur
Published: February 2022

Chronic nonbacterial prostatitis category III / chronic pelvic pain syndrome is detected in 90-95% of patients and depending on the disorders of proteolytic processes in the blood and prostate is subdivided into inflammatory (category IIIA) and non-inflammatory (category IIIB). The treatment of patients with chronic prostatitis must be complex, strictly differentiated and must provide for action on all etiological links and methods (drug and surgical) of treatment of CP. The paper determined the efficiency of entomological medication in chronic nonbacterial prostatitis and the contribution in preventing complications and improving the results of endoscopic transurethral treatment performed in this category of patients. It has been found that the administration of adenoprosine in combination with the standard complex physiotherapy of chronic nonbacterial prostatitis category IIIA and B (inflammatory and non-inflammatory) of the entomological preparation significantly increases the efficacy of the applied treatment, prevents or stops the evolution of chronic nonbacterial prostatitis consequences or intra- and postoperative complications in laser Ho: YAG transurethral endoscopic treatment, performed on the need of these categories of patients. Revolix laser prostate incision is a fast, harmless and promising procedure for, including, recurrent prostate sclerosis, and is used in the elimination of after bladder obstruction with satisfactory clinical results.
Characteristics of T lymphocyte content according to oxidative stress and antioxidant activity in patients with pulmonary tuberculosis and COVID-19 infection
Authors:   Institute of Phthisiopneumology ", Ghinda Serghei ,   Chiril Draganiuc",   , Republic of Moldova, Tudor Elena ,   Institute of Phthisiopneumology "Chiril Draganiuc", Republic of Moldova, Osipov Tatiana ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Chirosca Valentina ,   Institute of Phthisiopneumology "Chiril Draganiuc", Republic of Moldova, Pantea Valeriana ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Brumaru Albina ,   Institute of Phthisiopneumology "Chiril Draganiuc", Republic of Moldova, Gudumac Valentin ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova
Published: February 2022

In order to study the particularities of T lymphocyte content depending on the indicators of oxidative stress and antioxidant activity, in patients with pulmonary tuberculosis in association with COVID-19 coinfection, 42 patients were examined, of which: a) baseline - 21 patients with pulmonary tuberculosis and co-infection COVID-19, b) control group - 21 patients with pulmonary tuberculosis. At the patients included in the study, there were determined the leukocyte formula, the level of CD3, CD4, CD8 lymphocytes, the oxidative stress reaction as well as the antioxidant activity. As a result, it was determined that at patients with tuberculosis and COVID-19 coinfection: as the content of lymphocytes, and in particular, T lymphocytes decreases at patients with pulmonary tuberculosis and COVID-19 co-infection, the degree of oxidative damage of proteins and the predisposition of lipoproteins to oxidation increases significantly according to the data of the AOPP marker and the indicator of malonic dialdehyde of oxidative stress (malonic dialdehyde - DAM), which indicates the severity of oxidative stress reactions at these patients. The total antioxidant activity, determined by the ATS method at patients with pulmonary tuberculosis and COVID-19 co-infection, was significantly reduced, and according to the CUPRAC method it increased significantly as the content of lymphocytes and, in particular, lymphocytes decreased. The enzyme superoxide dismutase (SOD), catalase and the activity of the antioxidant protein ceruloplasmin at patients with pulmonary tuberculosis and COVID19 decreased significantly as the content of lymphocytes and, in particular, T lymphocytes decreased. Thus, the parameters of oxidative stress and antioxidant activity can be considered potential biomarkers markers of the evolution of pulmonary tuberculosis in association with COVID-19 infection.
Expression of glutation enzymes in splenic tissue is influenced by thiosemicarbazide derivatives
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Andronache Lilia , Pantea Valeriana ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Gulea Aurelian ,   Moldova State University, Svet Inna ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Ghinda Serghei ,   Institute of Phthisiopneumology "Chiril Draganiuc", Republic of Moldova, Privalova Elena ,   Institute of Phthisiopneumology "Chiril Draganiuc", Republic of Moldova, Smesnoi Valentina ,   Toma Ciorba Republican Clinical Hospital of Infectious Disease, Republic of Moldova, Gudumac Valentin ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova
Published: February 2022

The administration of new Schiff heterocyclic bases and their copper (II) complexes, thiosemicarbazide derivatives induces various influences on the activity of glutathione-dependent enzymes in splenic tissue. The selective action of the studied compounds on the expression of glutathione enzymes is evident, which is manifested by a tendency of insignificant decrease of glutathione reductase (GR) and glutathione peroxidase (GPO), insignificant increase of glutathione-S-transferase (GST) and marked depression of glutaredoxin levels. The slight increase of GST under the action of the studied compounds can be considered as a protective reaction aimed at stagnating the intensity of peroxide processes and supporting the activity of the glutathione cycle, and decreased the activity of glutaredoxin denotes their antiproliferative, cytostatic effect. Further studies are needed to evaluate the mechanisms of action of the investigated compounds on the activity of glutathione-dependent enzymes in other biosystems and animal experiments, to assess the practical importance of the obtained results.
The peculiarities and risk factors of patients with mental and behavioral disorders associated with tuberculosis
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Lesnic Evelina , Cotelea Eugen ,   Republican Narcology Dispensary, Republic of Moldova, Malic Alina ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova
Published: February 2022

Patients with mental and behavioral disorders have an increased risk of tuberculosis. The aim of the study was to identify the peculiarities and risk factors for tuberculosis in patients with mental and behavioral disorders. Material and methodology: a selective, descriptive, analytical and retrospective study was conducted, which included 71 tuberculosis patients diagnosed with mental and behavioral disorders registered in the period 2015-2019 with tuberculosis. The results: the particularities of the patients were male sex (58 (81.7%) cases), age between 35 and 64 years (48 (67.9%) cases). Risk factors for acquiring tuberculosis were: low socio-economic status (67 (85.9%) cases), poor living conditions - 58 (81.7%) cases, tuberculosis contact – 12 (16.9%) and associated pathologies, including HIV-infection – 11 (15.5%) cases. Although pulmonary localization of tuberculosis predominated - 61 (85.9%) cases, microbiological confirmation was established in 12 (16.9%) cases only. Therapeutic success was established in only 37 (52.1%) cases and death occurred in 20 (28.1%). Conclusion: the standardized management of patients with mental and behavioral disorders is a challenge for the successful completion of anti-tuberculosis treatment in the majority of the cases, and individualization according to patient needs will improve the therapeutic outcome.
Lipid spectrum in patients with pulmonary tuberculosis
Authors:   Tver State Medical University, Russian Federation, Ryasenskiy Dmitriy , Aseev Alexander ,   Tver State Medical University, Russian Federation, Elgali Akhmed ,   Tver State Medical University, Russian Federation
Published: February 2022

The evaluation of the lipid spectrum of the blood plasma and immunocyte membranes is important for timely diagnostic and correction of pathological changes revealed at the cytochemical level. The identification of lipid fractions using high-performance liquid chromatography (HPLC) allows for separate detection of minor fractions of lysophospholipids (lysophosphatidylcholine and lysophosphatidylethanolamine). The study was performed using a photometric sensor and reverse-phase column C18. The following fractions were obtained: lysophosphatidylcholine, lysophosphatidylethanolamine, sphingomyelin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, and phosphatidylserine. The ratio of these fractions is a sensitive marker of pathological shifts in the lipid spectrum both in the blood plasma and immunocyte membranes
The link between circadian clock and tumorigenesis
Authors:   University of Genoa, Italy, Daneri Arianna , Lupusor Adrian ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Moldovanu Ion ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Vovc Victor ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova
Published: February 2022

The circadian clock is fundamental for allowing the human body to work properly. Studies demonstrated that circadian disruption is a risk factor for a lot of pathological states and in this Review, the idea is to focus on tumorigenesis. Cancer is a social plague and it is interesting to note how the human lifestyle can be one of the most important reasons to explain the enormous spread of tumours. The crucial point described is the connection between light, melatonin and cancer genes; this triad has an important role in tumorigenesis. After that, there is a focus on breast cancer that is the most frequent in the world, and it is also demonstrated how social level and education can influence the possibility to develop cancer during life. In the end, there is a description of one of the possible new frontiers in the treatment of cancer: chronotherapy.
Comorbidities in patients with Parkinson's disease
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Caldarov Anastasia , Gavriliuc Olga ,   Diomid Gherman Institute of Neurology and Neurosurgery, Republic of Moldova, Rotaru Lilia ,   Diomid Gherman Institute of Neurology and Neurosurgery, Republic of Moldova, Andrusca Alexandru ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Fala Paula ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Gavriliuc Mihail ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova
Published: February 2022

A wide spectrum of comorbidities has been associated with Parkinson’s disease (PD), a progressive neurodegenerative disease that affects more than seven million people worldwide. Emerging evidence indicates that chronic diseases including diabetes, depression, anemia and cancer may be implicated in the pathogenesis and progression of PD. Recent epidemiological studies suggest that some of these comorbidities may increase the risk of BP and may precede the onset of motor symptoms. However, the mechanisms underlying these comorbidities remain elusive.
Energy metabolism inhibitors - a new group of antituberculous drugs
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Bacinschi Nicolae , Tudor Elena ,   Institute of Phthisiopneumology "Chiril Draganiuc", Republic of Moldova, Taraburca Mihaela ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova
Published: February 2022

The treatment of tuberculosis, despite the intensification of research into new drugs, remains a current problem of phthisiopulmonology due to the emergence of mycobacteria with multiple and extensive resistance, decreased patient adherence to treatment due to long duration of treatment and side effects, transformation of mycobacteria into latent metabolic forms. Elucidation of new compounds influencing metabolism and energy processes opens new perspectives to optimize the treatment of TB-MDR and TB-XDR, as well as the development of new therapeutic regimens that would shorten the duration of treatment by reducing the incidence of adverse reactions and increasing patient compliance
Tuberculosis in the COVID-19 pandemic period
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Osipov Tatiana
Published: February 2022

As a result of the analysis of bibliographic sources, important information was elucidated regarding the clinical manifestations and management of patients with tuberculosis associated with COVID-19 infection. The similarity of the clinical manifestations of these two diseases was confirmed along with the importance of investigations by the presence of “ground glass” opacities for the diagnosis of COVID-19 infection. The increased mortality among patients suffering from co-infection TB/COVID-19 was argued by the presence of cardiovascular and endocrine comorbidities.
Clinical features of chronic obstructive pulmonary disease in the elderly
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Bodrug Nicolae
Published: February 2022

Analysis of randomized, retrospective and prospective clinical, case-control, and observational studies revealed the following main features of COPD in the elderly: (1) COPD is a complex and common condition in elderly patients, characterized by high rates of disturbing symptoms, significant risk of cognitive and functional decline, disease progression, frequent use of health care, extremely difficult treatment and increased mortality. (2) The elderly have an increased prevalence of COPD: in subjects aged 65 years and over, it represents 14,2% (from 11,0% to 18,0%), compared to 9,9% (from 8.2% to 11.8%) in those aged 40 and over. (3) Simultaneously with the 2-4 times higher prevalence of COPD, the elderly patients, especially those aged 75 years or older, also have a higher burden of the disease: frequency, severity and impact of symptoms significantly higher. higher, tolerance to effort and lower daily activities, higher incidence of severe acute exacerbations and higher prevalence of systemic comorbidities. (4) COPD acute exacerbations and comorbidities have poorer results in elderly patients, fact manifested by an increased rate and duration of the hospitalization, an increased rate of repeted hospitalizations and a higher mortality rate. (5) COPD is a multifaceted condition that involves more than just obstruction of the airflow. Systemic inflammation contributes to the development of systemic effects (loss and dysfunction of skeletal muscle, osteoporosis, anemia, cachexia, neurocognitive dysfunction). (6) Multidimensional assessment and multidisciplinary intervention, well recognized in the geriatric population, should be extended to patients with COPD
Nosological structure and dynamics of adult population disability in the Republic of Moldova
Authors:   Institute of Phthisiopneumology ", Condratchi Diana ,   Chiril Draganiuc",   , Republic of Moldova, Pisarenco Nadejda ,   Municipal Clinical Hospital of Phtysiopneumology, Republic of Moldova, Martiniuc Constantin ,   Institute of Phthisiopneumology "Chiril Draganiuc", Republic of Moldova, Pisarenco Serghei ,   Institute of Phthisiopneumology "Chiril Draganiuc", Republic of Moldova, Luchian Mihai ,   National Council for Determining Disability and Work Capacity, Republic of Moldova
Published: February 2022

Nosological structure and dynamics of adult population disability in the Republic of Moldova Purpose. To study the current nosological structure and dynamics of the general and primary disability of the adult population in the Republic of Moldova. Materials and methods. Analysis of official statistics data (statistica.md, cnddcm.msmps.gov.md) for 2015-2019. Results. In 2015-2019, there was a wave-like change in the number of adults recognized as disabled for the first time in the republic and its increase in 2019 by ⅔ relative to 2018 (13713 and 8350, respectively). The structure of general disability, taking into account the degree of severity, changed little during the study period. In 2019, it was dominated by moderate disability - 47.1%; severe and severe disability was established in 38.0% and 14.9% of cases, respectively. The nosological structure of disability in general also changed little. In 2019, the main causes of disability in the adult population were tumors 20.0%, cardiovascular diseases - 18%, and diseases of the musculoskeletal system and connective tissue - 14.6%. At the same time, in 2019, respiratory diseases were the cause of disability in 2.7% of cases, or 1.4 times more often compared to 2018. Conclusions. In recent years, the main causes of disability in the republic are tumors, cardiovascular diseases, diseases of the musculoskeletal system and connective tissue, the proportion of respiratory diseases does not exceed 2.7%. In the structure of disability, moderate disability prevails.
New directions of research in the pharmacotherapy of Alzheimer’s disease
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Turcan Lucia , Caracas Anastasia ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Stirba Dumitru ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Latus Svelana ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Malancea Olesea ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova, Bacinschi Nicolae ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Republic of Moldova
Published: February 2022

Alzheimer’s disease, a neurodegenerative disease with a severe prognosis, accounts more than half of cases of dementia, associated with persistent and progressive memory loss, cognitive and personality disorders. According to the Alzheimer’s Association, in developed countries 13% of people over 65 years old suffer from Alzheimer’s disease, the fifth leading cause of death in patients of this age group. Data from the World Health Organization also shows that with the increase population and life expectancy, the overall incidence of Alzheimer’s disease will increase 4 times by 2050 and can reach 114 million. This will have a huge social impact and considerable economic burdens for the health system, as there are currently no efficient treatments for Alzheimer’s disease. The development of new, efficient and harmless drugs, designed to improve the quality and quantity of life of patients with Alzheimer’s disease remains a priority, and scientists globally combine their efforts to solve this problem. The etiopathogenetic links of Alzheimer’s disease are promising therapeutic targets for the discovery of efficient drug therapy.
موقف مترنيخ من أحداث المسألة الشرقية 1823 ــ 1840
Authors: البديري حمزة
Published: February 2022

يُعدّ المستشار النمساوي مترنيخ واحداً من أبرز الشخصيات الفاعلة في مجال الدبلوماسية الأوروبية خلال النصف الأول من القرن التاسع عشر ، إذ برزت تلك الشخصية بدهائها السياسي والدبلوماسي بعد عام 1815 ، وأصبحت ركناً أساسياً من الأركان المحافظة على السلام والاستقرار في أوروبا ، ‏لا سيما وأنه أصبح زعيماً لدبلوماسية وسياسة المحافظة على ذلك السلام ، من خلال مواقفهِ الرافضة للثورات والانتفاضات التي شهدتها الساحة الأوروبية ، لا سيما موقفه من أحداث و تداعيات المسألة الشرقية والصراع بين الدول الأوروبية الكبرى ، لأجل اقتسام أملاك السلطان العثماني ، وتحديداً روسيا وبريطانيا او روسيا والنمسا . لذا جاء هذا البحث ليبين الكيفية ‏التي تعامل بها مترنيخ بدبلوماسية المحافظة مع احداث وتطورات المسألة الشرقية، لاسيما ثورة اليونان والصراع بين السلطان العثماني وتابعه والي مصر محمد علي باشا.

        كان مترنيخ قد أظهر اهتماماً كبيراً بالمسألة الشرقية، نظراً لقرب الدولة العثمانية من النمسا، لذا عارض في بداية الامر أحداث الثورة اليونانية، عاداً إياها تمرداً على الحاكم الشرعي (السلطان العثماني)، إلا إن تدخل روسيا المباشر في أحداث تلك الثورة أرغم مترنيخ على تغيير موقفه منها‏، خوفا من احتمالية انفراد روسيا بها من جهة وخشيته من انفراط عقد التحالف المقدس الذي كان يربط النمسا مع الاخيرة من جهة أخرى.
The Role of Endoscopic Treatment in Acute Lithiasis Cholangitis (Retrospective Study of 186 Cases)
Authors: Berraida R. , Elkoti I. , Benhamdane A. , Laaroussi R. , Iroughman H. , Touibi Y. , Redouan I. , Guelleh M. Osmane , Addajou T. , Mrabti S. , Rouibae F. , Benkirane A. , Seddik H.
Published: February 2022

The acute cholangitis is a bacterial infection of the bile ducts due to an acute obstacle. It is a therapeutic emergency that can be life threatening. The purpose of this study is to evaluate the results of endoscopic drainage in patients with acute giocholitis.
Influence of the Robotic Milking System on Milk Production and Quality: Systematic Review
Authors: Grazziotin Rodrigo Chaves Barcellos , Rutz Fernando , Vieira Daniel José Cavalli , Da Silva Vitoria Mendonça , Chiesini Rodrigo Garavaglia , Viégas Julio , Bermudes Rogério Folha
Published: February 2022

This review aims to report the direct influence of a robotic milking system (RMS) on milk production and quality. The Scopus, SciELO, and Web of Science platforms were used as search databases. We followed the PRISMA protocol for the identification and screening of articles. Initially, 336 articles were identified. We excluded 186 articles for duplicity, 53 after screening abstracts and titles, 20 for lack of access, and 58 articles based on the exclusion criteria. Nineteen articles from 2002 to 2021 from 10 different journals were selected. We observed an increase in publications related to RMS in recent years, and the Journal of Dairy Science gained prominence among the journals whose articles were used in the present study. After lexicographic analysis of abstracts, it was clear that there were five predominant classes, and the keyword RMS was more associated with factors related to cows than milk. The study results contribute to a greater understanding of RMS research, providing farmers and readers with clarification on the actual influences on the dairy chain system and future research projects.
الصراع الحضاري و أدواته المعاصرة
Authors: عيسى عبد الرحمن علي
Published: February 2022

الصراع الحضاري و أدواته المعاصرة

The research discusses conflict of civilization as phenomenon now days.

The research criticizes the Islamic speech toword the western civilization and also criticize the western speech to Islamic civilization and point bow we can deal with civilizations.

The research discusses the western modern tools for this conflict, which inehide military, world new order, Globalization and psychological war.

The research discusses the agreement of Islam with other civilization for saving the humanity.

The conflict of civilization is a very important issue now day*.

To get balance for world we must choose a best speech
من ألوان التفسير : التفسير بالمأثور
Authors: أحمد عباس البدوي
Published: February 2022

من ألوان التفسير : التفسير بالمأثور

This thesis aims at emphasizing the reliability of orthodox interpretation of the Quran.

Recourse to other methods of interpretation should not be attempted unless the former procedure proves to be unattainable.

The research also draws attention to the many pitfalls attending other methods and interpretations.

These pitfalls are understood to refer to the authenticity of historical facts - the mere reporting and events meant to shed gigot and interpreting the Quran.

Hence meticulous care should be spent in sifting out these events, particularly the ones that relate to "Asbab Alnozul" (occurrences attending the revelation of the Quran).
قبيلة الهواوير بين دنقلا و كردفان
Authors: نعمة عبد السلام الحسين
Published: February 2022

قبيلة الهواوير بين دنقلا و كردفان

From its original homelands in Tripoli, the Hawawir tribe emmigrated in a Westerly and easterly directions.

From Lower Egypt it moved to upper Egypt, from where it was able to enter the Northern part of Bilad El- Nuba, modern Republic of the Sudan.

There it led a nomadic life.

It used to spend the wet Season grazing in the pastures of Northern Kordofan province.

The dry season it passes near the river banks in Dongola province.

In 1917 the authorities of the Condominium period decided to transfer the tribe wholly to Northern Kordofan for the benefit of their stock.

A conflict round (Dar) rights rose between them and the Kababish, the owner of the (Dar) tribe.

In 1953 a high court issued a decree for the benefit of the Kababish.

Then the Hawawir demanded to be transferred back to Dongola, province.

The application was rejected.

Though the tribe Nizara remained in Kordofan, Some branches of the Hawawir immigrated and settled in Northern & Khartoum provinces, and began to raise demands to be joined administratively to the provinces in which they were living, especially after 1971 when the local administration law, which depends on the distribution of the inhabitants on geographical & not tribal bases, was issued.

In 1983, a conference was held in Khartoum, to finalize the Hawawir question.

Due to the coSnference decisions some of the Hawawir were annexed to the localities of the provinces where they are actually living.

The headquarters of the Hawawir traditional leadership is still in Abu-Urog in Kordofan province
حقوق المرأة في القرآن الكريم
Authors: محمد حسن محمد عبد الرحمن
Published: February 2022

حقوق المرأة في القرآن الكريم

This is an exclusively Quranic study which sheds light on the most important rights Allah has given to woman as cited in the Quran and Sunnah.

Among these rights are the freedom of faith, right of inheritance and marriage, equality between wives, right to have a dowry, right to get the cost of breastfeeding and right to get money-compensation when divorced
دور الأخصائي الاجتماعي في التوعية بمفهوم الحقوق الزوجية في الإسلام
Authors: هاجر علي محمد بخيت
Published: February 2022

دور الأخصائي الاجتماعي في التوعية بمفهوم الحقوق الزوجية في الإسلام

In this study, the researcher tackles the concept of “Marital Rights”, with a specific concern on the concept of “Right” in general, according to the view point of many schools of thought, on one hand, and according to the view point of Islamic law, on the other hand.

It is made clear that, the process of realizing and performing “Marital Rights” is a real process of performing the will and orders of Allah, as well as avoiding what he condemned.

Hence “Marital Rights” are divided into three types: special rights that wife has on her husband, special rights that husband has on his wife, and common rights between both of them.

Having many qualities and the ability to respect certain principles, values and ethics, the social worker is highly accepted by the society and he can rush in two new realms, i.e.

the Call of Islam.

The social worker can play an essential role to acquaint the society about “Marital Rights” through the diversity of available means such as: communication, symposiums, debates, conferences, etc..., because there is clear lack of knowledge concerning this issue, the thing that results in the numerous problems, divorce cases and loose family ties.

The research concluded with important findings that Islam has solved the marital rights in a correct and a comprehensive way