bluuebunny/crossref_metadata_2025 huggingface dataset:
An Effect of Low Back Pain Relieving Program on the Back Muscle Strenght, Intensity of Pain, Disability Level in Elementary School Women Teacher
Authors: Choi Soon Young
Published: September 2023

The purpose of this study was to examine the effect of low back pain relieving program on back muscle strength, intensity of pain, low back disability level in elementary school teachers who have low back pain. subjects were elementary school women teachers who worked at eight elementary school located in Seoul. Intended subjects size were seventy consist of thirty-four experimental group(three schools) and thirty-six control group(five schools), but actual subjects size was forty-four.Among the forty-four patients subjects, twenty-three were experimental group receiving health education about right postures, etiologies of low back pain, diagnosis of low back pain and exercise program composed of muscle strengthening exercise, stretching exercises and twenty-one were control group. During the 8 weeks program, the subjects were received two times education and six times group exercise practices in 1st week and three times per week group exercise practices, two times education in other 7 weeks. This study as carried out from April 1, 1999 to June 30, 1999. Back muscle strength was measured by back muscle strength measuring machine and the intensity of pain were measured by the Visual Analogue Scale(VAS), and level of disability was measured by Oswestry low back pain disability scale. Study measurements were taken before and after 8 week exercise program. Data were analyzed using paired t-test, and ANCOVA.The results were summarized as follows.1. After low back relieving program, back muscle strength was increased significantly(p=0.000) and there was significant difference in back muscle strength change between experimental group and control group(p=0.002).2. After low back pain relieving program, pain on anterior bending, pain on posterior bending were decreased significantly than measurements before the program(p=0.000 p=0.000) and there was significant difference in pain on anterior bending and posterior bending change between experimental group and control group(p=0.000, p=0.000).3. After low back pain relieving program, Oswestry disability scale scores were decreased significantly(p=0.000, p=0.000) but there was no significant difference in Oswestry disability score change between experimental group and control group.
Effect of Education for Encouraging Breastfeeding on Practice of Breastfeeding
Authors: Seo In Suk , Jung Moon Sook , Suh Young Sook
Published: September 2023

This study was carried out to investigate effect of education for breastfeeding on practice of breastfeeding 171 primiparae (experimental group with education 83 and control group without education 88) who gave birth in hospitals located in Taegu City from October 25, 1999 to December 25, 1999 and planned to breastfeed their children after childbirth.The results of this study were as follows.1) The experimental group's practice rate of breast-feeding was statistically higher than the control group's at the points of two weeks, four weeks, eight weeks and twelve weeks after childbirth(p<0.05). However, the rate at the points of sixteen weeks and twenty weeks after childbirth was higher in the experimental group than in the control group but there was no significant difference between both groups.2) The experimental group's discontinuance rate of breast-feeding was lower than the control group's at all the points of two weeks, four weeks, eight weeks, twelve weeks, sixteen weeks and twenty weeks after childbirth, and it was statistically significant(p<0.05). The discontinuance rate of breast-feeding at the point of four weeks after childbirth was the highest in both groups. It accounted for 25.5% in the experimental group and 36.8% in the control group.3) The reason of which the rate appeared to be the highest among those for discontinuance of breast-feeding was the lack of breast milk. The rate accounted for 65.5% in the experimental group and 50.7% in the control group.In conclusion, the study suggested that the education for encouraging breast-feeding provided to the primiparae after childbirth has an positive effect on the practice of breast-feeding.
Comparison of lung ultrasound technique versus clinical method to evaluate the accuracy of size and placement of left endobronchial double lumen tube in patients undergoing elective thoracic surgery: a prospective observational study
Authors: Gupta Ekta , Singh Pooja , Tejpal Karna Sunaina , Niwariya Yogesh , Waindeskar Vaishali , Jain Sourabh , Panda Rajesh , Kumar Sandeep
Published: September 2023

Anthropometric measurements like height and gender have been frequently found to be inaccurate in prediction of size of double lumen tube (DLT). A tracheal ultrasonography (TUS) is a technique that can be used to predict the size of DLT and its correct placement for lung isolation. We aim to check the accuracy of ultrasound over clinical methods. This prospective study included 68 patients undergoing elective thoracic surgery requiring one-lung ventilation (OLV) with DLT. The groups were assessed for the size of DLT by either anthropometric measurement using height and gender (Group C) or ultrasound method (Group U). Further, the accuracy of placement of DLT was assessed through, either lung auscultation in group C or various ultrasonographic and ventilatory parameters such as lung isolation in the first attempt (lung sliding and lung pulse sign), oxygenation status and peak airway pressure, in group U. Surgeon satisfaction score was also compared in both the groups. The accuracy of predicted DLT size between Group C and Group U was statistically significant (p=0.044). In Group C, 56% of patients showed a mismatch between the predicted DLT size and the actual size required, while in Group U, the mismatch was only 32.4%. The accuracy of DLT placement through group C was 41% as compared to 79% in Group U. Surgeon satisfaction score was also significantly higher in Group U as compared to Group C (p=0.0028). Thus, our study suggests that tracheal and chest ultrasonography for DLT size selection and placement for lung isolation is superior to clinical methods.
Type 2 Diabetes Mellitus and Sarcopenia as Comorbid Chronic Diseases in Older Adults: Established and Emerging Treatments and Therapies
Authors: Mesinovic Jakub , Fyfe Jackson J. , Talevski Jason , Wheeler Michael J. , Leung Gloria K.W. , George Elena S. , Hunegnaw Melkamu T. , Glavas Costas , Jansons Paul , Daly Robin M. , Scott David
Published: September 2023

Type 2 diabetes mellitus (T2DM) and sarcopenia (low skeletal muscle mass and function) share a bidirectional relationship. The prevalence of these diseases increases with age and they share common risk factors. Skeletal muscle fat infiltration, commonly referred to as myosteatosis, may be a major contributor to both T2DM and sarcopenia in older adults via independent effects on insulin resistance and muscle health. Many strategies to manage T2DM result in energy restriction and subsequent weight loss, and this can lead to significant declines in muscle mass in the absence of resistance exercise, which is also a first-line treatment for sarcopenia. In this review, we highlight recent evidence on established treatments and emerging therapies targeting weight loss and muscle mass and function improvements in older adults with, or at risk of, T2DM and/or sarcopenia. This includes dietary, physical activity and exercise interventions, new generation incretin-based agonists and myostatin-based antagonists, and endoscopic bariatric therapies. We also highlight how digital health technologies and health literacy interventions can increase uptake of, and adherence to, established and emerging treatments and therapies in older adults with T2DM and/or sarcopenia.
Markers of Oxidative Stress, Inflammation, and Endothelial Dysfunction in Diabetic and Nondiabetic Patients with Chronic Kidney Disease on Peritoneal Dialysis
Authors: Nannapaneni Sai Sameera , Nimmanapalli Harini Devi , Lakshmi A. Y. , Vishnubotla Siva Kumar
Published: September 2023

Chronic kidney disease (CKD) is a low-grade inflammatory state which is accom–panied by elevated markers of oxidative stress, inflammatory, and endothelial dysfunction in patients on peritoneal dialysis (PD). These represent a key triad for the development and progression of atherosclerosis. The present study assessed the markers of oxidative stress, inflammatory and endothelial dysfunction in diabetic and non-diabetic CKD patients on PD. A cross-sectional study was undertaken on 100 CKD patients on PD, of whom 52 patients were nondiabetic and 48 were diabetic patients. Blood samples were estimated for malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) as markers of oxidative stress; interleukin (IL)-6, high-sensitivity C-reactive protein (hs-CRP), and fibrinogen as inflammatory markers; and markers of endothelial dysfunction such as nitric oxide (NO), carotid wall intimal medial thickness (CIMT), and number of plaques, among others. The MDA levels increased and FRAP levels decreased in both diabetic and nondiabetic CKD patients on PD. The levels of IL-6, hs-CRP, fibrinogen, NO, CIMT, and the number of plaques were significantly higher in diabetic patients than in nondiabetic CKD patients on PD. The lipid profile was significantly atherogenic in diabetic patients compared with nondiabetics CKD patients. The results showed increased oxidative stress, inflammation, and endothelial dysfunction in diabetic patients compared with nondiabetics CKD patients on PD.
Late Presentation for Kidney Biopsy: Clinical Presentations and Laboratory Findings
Authors: Mohammed Ehab , Al Salmi Issa , Atris Ahmed , Al Ghonaim Mohammed , Ramaiah Shilpa , Hannawi Suad
Published: September 2023

Although the number of patients reaching end-stage kidney disease without a biopsy- proven diagnosis is increasing, kidney biopsies play a key role in diagnosing kidney disease. We analyzed prospective data from patients with kidney disease who underwent percutaneous native kidney biopsies from January 2006 to December 2017. Demographic data, clinical presentations, and the laboratory and radiological findings at the time of biopsy were analyzed. Of 530 patients, 42.8% were male. The mean age was 33.9 (32.8–34.9.2) years; 66.3% were aged 25–64 years. Edema was the main clinical presentation (61.9%), with clinical urine changes seen in 66.7%. Most (89.6%) were nondiabetic; 46.8% had high blood pressure or were on antihypertensive therapy. Most patients (77.5%) were in Stages I, II, and III, and 12.3% underwent hemodialysis at the time of admission. Most (54.4%) were obese. Low hemoglobin (31.8%), high triglycerides (30%), high total cholesterol (58.2%), low serum albumin (73.9%), nephrotic proteinuria (61.8.6%), and microscopic hematuria (79.8%) were the main laboratory findings. The immunological investigations showed that antinuclear antibodies, positive anti-double-stranded DNA (anti–dsDNA), and extractable nuclear antigens were positive in 29.6%, 20.7%, and 19.7%, respectively. Perinuclear antineutrophil cytoplasmic antibodies (ANCA) were positive in 9.6% and cytoplasmic ANCA were positive in 5.4%, whereas immunoglobulin A was detected in 4.6%. More than one- third of the patients had reached advanced chronic kidney disease (CKD) Stages IIIB, IV, and V. This indicates the need to increase awareness about CKD, greater utilization of kidney biopsies, and earlier investigations to enable accurate diagnoses, and proper and timely management.
Coronavirus Disease 2019 Infection and ABO Blood Groups in a Hemodialysis Cohort in the United Arab Emirates
Authors: Al Madam Ayman , Ahmed Wasim , Al Obaidli Ali Abdul Kareem , Smith Edward R. , Holt Stephen G.
Published: September 2023

Some epidemiological data have implicated blood groups in susceptibility to coronavirus disease 2019 (COVID-19) infection. We were interested to see if there was any apparent effect of different ABO blood groups on susceptibility to COVID-19 infection in unvaccinated hemodialysis (HD) patients, as they had a high rate of mortality from this infection. Blood group O has been suggested to be protective against COVID-19 infection; however, since the ABO frequency is affected by ethnicity, we looked at infection frequency and blood group and corrected the expected frequency for the ethnicity of our cohort. We examined 249 HD patients presenting with a positive COVID-19 polymerase chain reaction regarding their ABO blood group and compared the ABO frequencies with published data for the United Arab Emirates (UAE), as well as international and historical ABO data on dialysis frequency. Although there was an apparent protective effect of blood group O when we compared blood group frequencies with the UAE data, this disappeared when corrected for ethnicity. We concluded that any association of the ABO blood group with COVID-19 infection is unlikely to be of major importance and should not be used to reassure patients that they are mildly protected against COVID-19 without vaccination.
Correlation between Random Urinary Protein-to-creatinine Ratio and 24-h Urinary Protein Excretion in Preeclampsia
Authors: Rashid Shaista , Khan Muhammad Tassaduq , Jahan Erum
Published: September 2023

This study aimed to determine the correlation between random urinary protein-to-creatinine ratio in single-voided urine samples and 24-h urinary protein excretion in pregnant women with preeclampsia. A cross-sectional study was conducted at the Department of Gynecology and Obstetrics, Abbasi Shaheed Hospital, Karachi, Pakistan, from July 2019 to June 2020. Fifty women with singleton pregnancy after 20 weeks of gestation with hypertension and 2+ proteinuria or more, according to a dipstick test, were included. Those with chronic hypertension; preexisting renal disease; gestational diabetes; eclampsia; hemolysis, elevated liver enzymes, a low platelet count syndrome; and coexisting urinary tract infections were excluded. Two random urine samples taken at 9:00 a.m. and 2:00 p.m. and 24-h urine samples were collected to evaluate the random urinary protein-to-creatinine and the 24-h protein excretion, respectively. The correlation coefficient (r) between them was calculated using Pearson's correlation test. The patients' mean age was 28.58 ± 5.09 years and their mean gestational age was 32.74 ± 4.44 weeks. Twenty-eight (56%) women were primigravidas, and 22 (44%) were multiparous. The average serum creatinine was 0.80 ± 0.16 mg/dL. The mean random urinary protein-to-creatinine ratio was 0.93 ± 0.7 mg/mg, and the mean 24-h urine was 481.08 ± 20.10 mL. A strong positive correlation was found between the protein-to-creatinine ratio and 24-h urinary protein excretion (r = 0.655; P = 0.01). We concluded that the protein-to-creatinine ratio in spot urine samples could be used as an alternative to in 24-h collection of urine to determine protein excretion in preeclamptic pregnant women.
Association of HLA-A, HLA-B, and HLA-DR alleles in oral squamous cell carcinomas and its correlation with clinical staging
Authors: Shahab Juhi , Ahluwalia Charanjeet
Published: September 2023

Background:

Oral squamous cell carcinoma (OSCC) is the most common malignant epithelial neoplasm affecting the oral cavity. It is the third-most common cancer in India. Several human leukocyte antigen (HLA) types are associated with an increased risk of various immunologically mediated diseases. There is also evidence that the HLA gene complex may mediate susceptibility to or protection from malignancies. Various studies have been conducted worldwide, but there is a paucity of literature in India regarding the association of HLA alleles in oral squamous cell carcinoma patients. In our study, HLA class I (HLA-A and HLA-B) alleles and class II (HLA-DR) alleles were determined in 100 patients with OSCC and an equal number of healthy controls (100) were taken for comparison. DNA was extracted with Innotrain kit, and HLA typing was performed with Fluogene. Data were analyzed using SPSS software version 21.0.

Aims:

To study the association of HLA-A, HLA-B AND HLA-DR alleles in oral squamous cell carcinomas and its correlation with clinical staging.

Objectives:

1. To compare the HLA-A, HLA-B and HLA-DR alleles in oral squamous cell carcinoma patients with healthy controls. 2. To correlate HLA-A, HLA-B, HLA-DR aleles with clinical staging of oral squamous cell carcinoma.

Materials and Methods:

The study was a cross sectional study conducted in the Department of Pathology and Department of Surgery, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi. Blood samples of 100 histologically diagnosed cases of oral squamous cell carcinoma and 100 random healthy age and sex matched controls were chosen.

Results:

All the cases were compared with the healthy controls, and the data were correlated with the clinical stage of the oral squamous cell carcinoma. HLA-A * 02, HLA-A * 24, HLA-B * 15, HLA-B * 40, HLA-B * 52, HLA-DRB1 * 07, and HLA-DRB1 * 15 alleles were found to have a higher frequency than in controls and were frequently found associated with clinical Stage III of these carcinomas.

Conclusion:

Thus, this study helps us to establish the possible relationship between HLA-A, B, and DR alleles in oral squamous cell carcinomapatients and its correlation with clinical staging, about which there is paucity in the Indian literature to the best of our knowledge.
Long-term functional and radiological outcomes of cervical disc arthroplasty at a tertiary level spine center in India: A retrospective cohort analysis with minimum 2 years of follow-up
Authors: Dave Bharat , Chauhan Vikrant , Amin Prarthan , Mayi Shivanand , Krishnan Ajay , Degulmadi Devanand , Rai Ravi Ranjan , Dave Mirant , Bali Shiv Kumar , Charde Pranav , Anil Abhijith
Published: September 2023

Context:

Cervical disc arthroplasty (CDA) was developed for the treatment of cervical disc disease with the potential advantages of preservation of physiological motion at a discal level, thereby potentially reducing adjacent level stresses and degeneration, which were a known complication of anterior cervical arthrodesis. The objective of this study was the assessment of long-term functional and radiological outcomes overtime in all the patients who underwent CDA from 2011 to 2019 at our institute.

Materials and Methods:

Forty-eight patients who underwent CDA (2011–2019) with a minimum 2-year follow-up were retrospectively evaluated. The functional outcome included the Visual Analog Score (VAS) and Neck Disability Index (NDI). Radiographs were assessed for range of motion (ROM) at the index surgical level, presence of heterotopic ossification (HO), and adjacent segment degeneration.

Results:

The mean follow-up was 5.79 ± 2.96 (2.16–11.75) years. Significant improvement (P < 0.05) was observed in the VAS (8.91 ± 2.52 [preoperative] to 0.89 ± 1.27 [follow-up]) and NDI (65.5% ±23.06% [preoperative] to 4.79 ± 3.87 [follow-up]) score. Motion at index level increased significantly from 5.53° preoperatively to 7.47°, and 92% of the implanted segments were still mobile (referring to the threshold of ROM > 3°). HOs are responsible for the fusion of 4/50 (8%) levels at the last follow-up. Distal and proximal adjacent disc degeneration occurred in 36% and 28% of patients, respectively. No migration of the implant was observed on the radiograph.

Conclusion:

Our study showed favorable clinical outcome of CDA with preservation of ROM at the index surgical level. CDA can be a promising alternative to anterior cervical arthrodesis when properly indicated.
Multilevel ossification of the posterior longitudinal ligament causing cervical myelopathy: An observational series of North American patients
Authors: Ledesma Jonathan A. , Issa Tariq Z. , Lambrechts Mark J. , Hiranaka Cannon Greco , Tran Khoa , O’Connor Patrick , Canseco Jose A. , Hilibrand Alan S. , Kepler Christopher K. , Albert Todd J. , Vaccaro Alexander R. , Schroeder Gregory D. , Anderson David Greg
Published: September 2023

Background:

Few studies regarding ossification of the posterior longitudinal ligament (OPLL) outside of Asia currently exist in the literature. A set of patients with multilevel cervical OPLL causing symptomatic myelopathy or radiculopathy from a North American sample is analyzed.

Objective:

The objective of this study was to describe the demographics, radiographic findings, and surgical outcomes of a cohort of North American patients with degenerative spondylosis presenting for operative management of multilevel (>3 segments) cervical OPLL.

Materials and Methods:

Forty-three patients diagnosed with multilevel cervical OPLL and degenerative spondylosis presenting with symptomatic cervical myelopathy or radiculopathy were surgically treated over a 9-year period at a single tertiary care academic medical center. Radiographic measurements were performed on preoperative computed tomography and magnetic resonance imaging images of the cervical spine. Clinical outcomes included pre- and postoperative Nurick scores, 90-day readmission, complication, and revision surgery rates.

Results:

The mean age was 66.1 ± 10.9 years with a mean latest follow-up time of 32.7 ± 16.4 months. Most patients had previous diagnoses of obesity (70.7%) and hypertension (55.8%). At least one-quarter of patients were diagnosed with type 2 diabetes (34.9%), hyperlipidemia (41.9%), cardiovascular disease (25.6%), or chronic kidney disease (25.3%). The most common OPLL subtype was segmental (39.5%) and spanned a mean of 3.54 ± 1.48 segments. Myelopathic symptoms were present in 88.4% of patients. All patients experienced significant neurologic improvement at 3-week and latest follow-up (P < 0.001 for both).

Conclusions:

Obesity, diabetes, and other metabolic derangements in patients with existing cervical spondylosis may be risk factors for a particularly aggressive form of multilevel OPLL. Various operative approaches may be employed to achieve adequate neurologic recovery. Further workup for OPLL in patients with these risk factors may prove beneficial to ensure appropriate operative management.
Construction of an enteral nutrition evaluation system for critically ill patients based on the Delphi method
Authors: Yao Yanrong , Liu Jingli , Xue Hongmei , Wang Xiaoyan , Yao Weijie , Liu Na , Wang Zuozheng , Mi Guangli
Published: September 2023

Background:

This study aimed to construct an enteral nutrition evaluation system for critically ill patients using the Delphi method to direct the formulation of enteral nutrition support strategies and reduce interruption to enteral feeding.

Methods:

We used domestic and foreign databases to obtain and analyze the literature and form “The Whole-Proceeding Enteral Nutrition Evaluation System for Critically Ill Patients.” The Delphi method was used to conduct two rounds of expert opinion consultation, combined with the suggestions from the research group to finalize the nutrition evaluation content of the system.

Results:

After two rounds of expert consultation, a nutrition evaluation system was formed around three dimensions: before the start, during, and after the end of nutritional support. The effective recovery rates of the two rounds of expert consultation were 90.0% (18/20) and 100.0% (18/18), respectively. Authority coefficients were 0.865 and 0.908, while Kendall coordination coefficients were 0.108 (P < 0.05) and 0.115 (P < 0.001), respectively. Finally, the full enteral nutrition evaluation system for critically ill patients was constructed based on the Delphi method, including three primary items and seven secondary and 28 tertiary indicators.

Conclusion:

The established “Whole-Proceeding Enteral Nutrition Evaluation System for Critically Ill Patients” has high consistency from expert opinions and reliability, which can provide a practical evaluation tool for the process of enteral nutrition for severe patients.
Bearing Fault Classification Using Multi-Class Machine Learning (ML) Techniques
Authors: Sujatha C , Mohan Aravind
Published: September 2023

Bearing elements are widely used in rotating machines and their failure results in a considerable amount of downtime of the machines. The aim of this work is to classify defects in a bearing. Three types of classification have been done: (i) Binary classification: classification as non-defective or defective bearing, (ii) 3-class classification such as non-defective, defective with inner ring defect and defective with roller defect and finally (iii) 7-class classification corresponding to no defect condition, three ring defect conditions pertaining to indentations of three different sizes on the inner ring and three roller defect conditions corresponding to indentations of three different sizes on the roller. The open-access data generated using a rolling bearing test rig from the Politecnico Di Torino, Italy, has been used for this work. The data had been obtained using 2 accelerometers on two bearing housings for multiple load and speed combinations. For classification, in the present work, classical ML algorithms such as logistic regression (LR), K-Nearest Neighbour (K-NN) classification algorithm, random forest (RF), support vector classifier (SVC) and kernel support vector machine (KSVM) have been used. All these techniques gave very promising results, the classification accuracy varying from 0.7969 to 0.9996 for all speed-load conditions. Such classification work across multiple operational conditions, with multiple fault conditions and multiple signatures with faulty components, has not been reported.
Structure of legal consciousness in the system of human rights: civilizing and psychological aspect of the development of the society
Authors: Skrypniuk Oleksandr , Zhovnirchyk Yaroslav , Shamrayeva Valentina , Tsumarieva Natalia , Bandura Ivan
Published: September 2023

The main objective of the article was to analyze the structural parts of legal consciousness in the human rights system: with special emphasis on the civilizing and psychological aspect of societal development. In this context, the subject under discussion is legal consciousness as a phenomenon and concept in the human rights system. Based on the results of the study it was determined that legal consciousness is a set of legal ideas, feelings, beliefs and assessments that express the attitude of individuals, social groups and society as a whole to the law and, to the behavior of people in the field of law. It is concluded that the experience of legal consciousness, has a complex internal structure and a sensationalist character, therefore, allows to know and understand more fully and objectively the legal reality of the structural elements of consciousness in the system of human rights, revealing its civilizational and psychological aspect in the development of society. Thanks to the modern method of modeling, a model for the study of the development of legal consciousness in the human rights system has been formed. This made it possible to achieve the stated object.
Formation of military political leadership through the lens of history
Authors: Horiacheva Kira , Yurkov Anatily , Savchenko Andrii , Snapkova Nataliia , Kilderov Dmytro
Published: September 2023

By means of a documentary analysis methodology, the purpose of the article was to determine the main characteristics of the formation of military political leadership. The sources of the study are the classical works of Greek philosophers: Plato, Aristotle, and also the treatise “The Art of War”, in which the famous Chinese general Sun Tzu stresses the need for self-control, emphasizes the possibility of avoiding confrontation without a prior in-depth analysis of the situation and one’s own capabilities. In the process of research, the authors defined the concept of the military-political leader, as well as highlighted the fundamentals of the quality of the leader’s personality. The authors come to the conclusion that the military manager is a professional leader, a person who has special knowledge, talent and also has some information about the news in the field of combat organization, the use of weapons and management of a military organization. He is also a person who not only knows how to influence subordinates to his will, but also knows how to organize teamwork and be responsible for his actions.
Administrative coercion as the method for providing state defense order
Authors: Povydysh Vladyslav , Makarchuk Vitalii , Nakonechna Iryna , Tsybulnyk Nelli , Kobko Yevhen
Published: September 2023

Using the logical and semantic method the purpose of the research was to reveal the essence of administrative coercion as a method of ensuring the state defense order. In the results of the research the article defines administrative coercion as the method of ensuring the order of defense of the state in the system of legal and administrative measures to assert compliance with the duties and requirements related to the implementation of the studied institution. In terms of practical significance, it is established that administrative coercion is aimed at ensuring the smooth, efficient and operational functioning of the military-industrial complex and other important sectors providing production, supply and development of military equipment, as well as scientific research institutes and organizations engaged in the development of new technologies for defense needs. It is concluded that administrative coercion is an important and necessary method in the process of ensuring Ukraine’s security and defense capabilities, as it allows controlling the production and supply of strategically important goods and services.
The essence of administrative legal relations in the sphere of social security for persons with disabilities
Authors: Fomichov Kostyantun , Maksymenko Nataliia , Yunin Oleksandr , Rezvorovych Khrystyna , Shevchenko Taisia
Published: September 2023

The purpose of the study was to learn the essence of administrative and legal relations in the sphere of social protection of persons with disabilities, to identify their characteristic features and, at the same time, to provide a legal description. A complex of scientific knowledge methods were used, based on the technique of analysis and synthesis, formal-legal, logical-semantic and statistical generalization. Administrative and legal relations in the sphere of social protection of disabled persons are an integral part of the state administration, whose policy is aimed at ensuring their social protection on an equal footing with other citizens, in terms of their participation in public life. It is concluded that, the state policy in the field of social protection of persons with disabilities consists in providing a certain list of social payments, social services and implementation of rehabilitation measures, etc., which determines the special legal status of these persons. It has been shown that military actions on the territory of Ukraine are associated with an increase of citizens suffering from various degrees of damage, leading to persistent disorder of health and life activities, in terms of disability.
The role of intellectual property in the post-war development of the health care sector
Authors: Kronda Olha , Chomakhashvili Olena , Ponomarova Olena , Kashyntseva Oksana , Kryvosheina Inha
Published: September 2023

Understanding the role and necessity of the use of intellectual property in the field of medicine is the basis for the proper development of this field in the postwar period, as well as for the entire healthcare system. Therefore, the purpose of the study was to determine the impact and prospects of the use of intellectual property in the development of the Ukrainian health sector, post-war. The methodological basis of the work consists of general and special scientific methods: analysis and synthesis, generalization, dialectical, axiological, legal-formal, legal-comparative and structural system. The result of the work shows the necessity of using heterogeneous objects of intellectual property, in particular, those in the field of copyrights and patents, for adequate reform and effective modernization of the health sector. It is concluded that intellectual property is designed not only to ensure the property and non-property interests of the subject of the specified property, but, in addition, is intended to ensure the needs of society in general in the appropriate sphere, where the objects of intellectual property find their concrete application.
La responsabilidad del Médico Ocupacional por omisión en la notificación de enfermedades profesionales
Authors: Roca Pilozo Jose Antonio , Molleturo Jiménez Julio Adrian
Published: September 2023

La importancia de este artículo radica en determinar la falta para la notificación de una enfermedad profesional relacionada al trabajo, ¿por qué se omite y de quien es la responsabilidad?, será para el profesional de Salud Ocupacional si realizó el diagnóstico correcto o de las empresas donde labora un trabajador. Las Enfermedades Profesionales u Ocupacionales resultan de vital importancia por las repercusiones para el trabajador, generando cambios en el desempeño laboral, el estado de salud, los gastos económicos y la afectación al entorno familiar que dependen de él. Los controles sanitarios de los trabajadores en las empresas públicas y privadas se desarrollan mediante un plan de vigilancia de salud periódica que incluye métodos para evaluar, detectar y controlar cambios que pueden presentarse durante las actividades laborales. La afectación crónica de la salud relacionada con el trabajo, a pesar del cumplimiento de la vigilancia médica, de capacitación en prevención de riesgos y prevención de enfermedades y el sitio de trabajo adecuado, se puede considerar presunción de enfermedad profesional, si este cumple los criterios de evaluación. El caso sospechoso se comunica a las autoridades de las empresas para proceder a notificar al ente de control en el país que corresponda, En Ecuador, al departamento de Riesgos de Trabajo del Instituto Ecuatoriano de Seguridad Social IESS.
From the history of ossetian studies: anniversary of V.F. Miller in Ossetia in 1924
Authors: Гостиева Л.К.
Published: September 2023

Статья посвящена проведению в 1924 г. в Осетии значимого для наци- ональной культуры события – юбилея в честь 75-летия со дня рождения и 10-летия со дня смерти выдающегося деятеля отечественной науки конца XIX – начала ХХ в., одного из основателей научного кавказоведения академика В.Ф. Миллера. Проанализиро- ван протокол торжественного заседания в честь юбилея из фондов Центрального го- сударственного архива РСО-А, материалы которого впервые вводятся в научный обо- рот. Рассмотрено содержание докладов ведущих ученых Осетии, в которых отражен комплексный, дисциплинарный подход В.Ф. Миллера к осетиноведческим исследовани- ям. Отмечено, что выступления с личными воспоминаниями о В.Ф. Миллере расширили наши знания о плодотворных научных связях ученого с представителями осетинской интеллигенции и о его высоких личностных качествах.

The article is devoted to the holding in 1924 in Ossetia of a significant event for the national culture - the anniversary in honor of the 75th anniversary of the birth and the 10th anniversary of the death of an outstanding figure of Russian science of the late XIX - early XX centuries, one of the founders of scientific Caucasian studies Academician V.F. Miller. The protocol of the solemn meeting in honor of the anniversary from the funds of the Central State Archive of North Ossetia-Alania, the materials of which are introduced into scientific circulation for the first time, is analyzed. The content of the reports of the leading scientists of Ossetia, which reflects the complex, disciplinary approach of V.F. Miller to Ossetian studies. It is noted that speeches with personal memories of V.F. Miller expanded our knowledge about the fruitful scientific relations of the scientist with representatives of the Ossetian intelligentsia and about his high personal qualities.
Everyday Life and Historical Memory of the Inhabitants of the Ossetian Villages of the Sarıkamış District according to the Diaries of Süleyman Kazmaz, 1940–1941
Authors: Чочиев Г.В.
Published: September 2023

В публикации дневниковых записей турецкого этнографа-краеведа С. Казма- за представлено описание бытовых и социокультурных особенностей жителей четырех осетинских сел Сарыкамышского округа Карсского вилайетаТурецкой Республики в на- чале 1940-х гг. Материал имеет определенную ценность в контексте осетинской исто- рии и этнологии как исходящая из первых рук документальная фиксация характера по- вседневной жизни и состояния коллективной памяти указанного населения на этапе его полностью изолированного от «материнского» этноса существования.

The publication of the diary entries of the Turkish ethnographer and local historian S. Kazmaz describes the socio-cultural characteristics of the inhabitants of four Ossetian villages in the Sarıkamış district of the Kars vilayet of the Republic of Turkey in the early 1940s. The material has a certain value in the context of Ossetian history and ethnology as a first-hand documentary fixation of the nature of everyday life and the state of the collective memory of the specified population at the stage of its completely isolated existence from the “maternal” ethnic group.
POLITIČKE PRILIKE U SRBIJI I NARODNI POSLANICI IZ OKRUGA KRAGUJEVAČKOG U NARODNOJ SKUPŠTINI SRBIJE 1908-1912. g.
Authors: Radovanović Boriša
Published: September 2023

The annexation crisis (1908-1909) deeply affected the national interests of Serbia and the political life in the country. In the period 1908-1912, in the conditions of a possible crisis, political pluralism, the influence of the army, increased foreign policy pressure for the recognition of the annexation, the Serbian parliament was in session and made important decisions. Despite the difficulties in Serbia, on the domestic, political and foreign policy level, liberal-democratic institutions were gradually established, which placed the Serbian state among the modern parliamentary democracies in Europe. The deputies elected in elections in May 1908 in Serbia represented the Serbian political elite, which formed during this period. Once again, it showed that the Serbian people are capable and mature and will respond to all external and internal challenges in difficult political decision-making moments to found a modern Serbian state.
ŽIVOJIN O. DAČIĆ (1874 – 1920)
Authors: Stanojević Marko
Published: September 2023

Živojin O. Dačić was a professor and the manager of the State Printing House of the Kingdom of Serbia. He served as a high school teacher in Vranje, Jagodina, and Belgrade. He was a clerk of the Ministry of Education, the State Archives, and the Secretary of the University from 1901 to 1910. He left this position to become the manager of the State Printing House, where he remained until 1919. He dedicated his life to introducing literacy to the Serbian people in Serbia and abroad. Živojin had a strong desire to help his mostly educated people by founding and printing newspapers. That desire was especially expressed while he was working as the Secretary of the University of Belgrade. Carried by that thought, he founded "The Public newspaper"(,,Narodne novine’’) in Belgrade in 1907. Working on the education of his people, he paid special attention to the newly liberated parts of old Serbia, after 1912. Živojin Dačić was a prominent Serbian patriot and the country’s finest servant. Wherever he was and whatever position he took, he tried with all his efforts to help the Serbian people to survive in those areas. At the same time, he aspired to promote education. He spent the second Balkan war on the front line in Old Serbia, leaving a testimony about the war with the Bulgarians. Unlike the Balkan wars, he spent the First World War in Geneva. Just before the end of the war, he became seriously ill. He died on May 24th, 1920 in Belgrade.
PENGARUH MODEL INQUIRY LEARNING BERBANTUAN KINEMASTER PADA PEMAHAMAN KONSEP SISWA PADA MATERI PENGUKURAN KELAS X SEMESTER I SMA NEGERI 1 PARLILITAN TP 2022/2023
Authors: Lubis Lasmida , Malau Bertina , Susanto Irwan , Panjaitan Jelita
Published: September 2023

Penelitian ini bertujuan untuk mengetahui apakah ada pengeruh yang signifikan penggunaan model pembelajaran inkuiri berbantuan kinemaster pada pemahaman konsep fisika siswa pada materi pokok pengukuran kelas X semester I SMA Negeri 1 Parlilitan T.P 2022/2023. Jenis penelitian ini yakni kuantitatif  eksperimen yang dilaksanakan di SMA Negeri 1 Parlilitan dengan populasi 2 kelas yang berjumlah 50 orang meliputi kelas X-1 memakai model pembelajaran langsung dan X-2 memakai model pembelajaran inkuiri berbantuan kinemaster. berlandaskan hasil uji statistika didapat t hitung= 2,91 dan t tabel= 1,676 pada taraf signifikansi α = 0,05. Sebab t hitung> t table hal ini memperlihatkan bahwasanya ada dampak yang signifikan dengan memakai model Inkuiry learning berbantuan kinemaster pada pemahaman konsep siswa SMA.
KORELASI ANTARA PENGINJILAN DENGAN PEMURIDAN MENURUT MATIUS 28:18-20 MAHASISWA PENDIDIKAN AGAMA KRISTEN FAKULTAS KEGURUAN DAN ILMU PENDIDIKAN UDA MEDAN
Authors: Karo-karo Selamat , Pardede Marioga , Gulo Yona , Gultom Fransiskus
Published: September 2023

Tujuan dari Riset ini yaitu untuk mengetahui hubungan yang signifikan antara penginjilan dan pemuridan pada mahasiswa Pendidikan Agama Kristen Fakultas Keguruan dan Ilmu Pendidikan Universitas Derma Agun Medan. Jenis Riset ini yaitu deskriptif korelasional Populasi Riset ini yaitu mahasiswa pendidikan agama Kristen Fakultas Keguruan dan Ilmu Pendidikan Universitas Darma Agung Medan yang berjumlah 39 orang, sampel Riset ini yaitu 39 orang dengan teknik complete sampling. Instrumen yang digunakan dalam pengumpulan data yaitu kuesioner 28 item untuk penginjilan yang valid, 14 item untuk pemuridan yang valid dan 14 item, dengan 4 pilihan sebelum kuesioner digunakan untuk menguji validitas dan reliabilitasnya. Hasil pengujian berdistribusi normal dengan menghitung x2 hitung < x2tabel (33,06 < 54,57) untuk menganalisis kebutuhan analisis data penginjilan mahasiswa pendidikan agama Kristen Fakultas Keguruan dan Ilmu Pendidikan Universitas Darma Agung Medan. Data normal pemuridan mahasiswa Pendidikan Agama Kristen Fakultas Keguruan dan Ilmu Pendidikan Universitas Dharma Agung Medan berdistribusi normal dengan hasil perhitungan x2h < x2 t (29,361 < 54,57). Hasil uji linearitas untuk data penginjilan dan pemuridan yaitu linear dengan persamaan Y=10.24+0.827. Universitas Darma Agung Meadan memiliki kecenderungan sedang (41%), sedangkan kemuridan mahasiswa Pendidikan Agama Kristen Fakultas Keguruan dan Ilmu Pendidikan Universitas Darma Agung Medan cenderung sedang (38,4%). = 0,308. rhitung = 1,956 dan rhitung > rtabel (1,956 > 0,308) . Hal ini menunjukkan bahwa ada hubungan antara penginjilan dan pemuridan menurut Matius 28:18-20, mahasiswa Pendidikan Agama Kristen Fakultas Keguruan dan Ilmu Pendidikan Universitas Dharma Agung Medan menguji tingkat signifikansi kedua variabel tersebut. . "Uji thitung 13,008 tabel 1,684> tt (13,008 > 1,684) diperoleh. Sehingga hal ini menunjukkan bahwa ada hubungan yang signifikan antara penginjilan dengan pemuridan menurut Matius 28:18-20 oleh Mahasiswa Pendidikan Agama Kristen Fakultas Keguruan dan Ilmu Pendidikan Universitas Dharma Agung Medan.
Moderne Immuntherapie: Update zu Antikörper-Wirkstoff-Konjugaten bei hämatologischen Neoplasien
Authors: Steinhardt Maximilian , Xiao Xianghui , Zhou Xiang , Einsele Hermann
Published: September 2023

Antikörper-Wirkstoff-Konjugate (ADCs) finden zunehmende Verbreitung in der Therapie hämatologischer Neoplasien. Basierend auf ihrem eigenständigen Wirkmechanismus zeichnen sich ADCs durch ein spezifisches Nebenwirkungsprofil aus, das abhängig von der Zielstruktur und dem gekoppelten Toxin ist. Aufgrund ihrer guten Wirksamkeit sind ADCs mittlerweile nicht nur im Rezidiv des Multiplen Myeloms (MM), von Lymphomen und der akuten B-Zell-lymphatischen Leukämie (B-ALL), sondern auch in der ersten Linie des diffus großzelligen B-Zell-Lymphoms (DLBCL), der CD33-positiven akuten myeloischen Leukämie (AML) und des fortgeschrittenen M. Hodgkin zugelassen. Aufgrund ihres positiven Kosten-Nutzen-Profils werden viele weitere ADCs in klinischen Studien evaluiert. Dieser Beitrag bietet eine Übersicht über die schon zugelassenen und noch in Entwicklung befindlichen ADCs.
Modification of interactive multimedia with the ARA MODEL: study of development of football learning models in pandemic times
Authors: Tanri Afri , Aprial. M Benny , Mashud Mashud , Kristyandaru Advendi , Kahri Ma'ruful , Basuki Sunarno , Samodra Y Touvan Juni , Warni Herita , Arifin Syamsul , Puspita Wati Isti Dwi , Thamrin Lily , Suryadi Didi
Published: September 2023

Background and Study Aim. The learning process is very important in education. Learning is a process of educational interaction designed to make students learn actively and be able to change their behavior through learning experiences. Learning was done online during the Covid-19 epidemic. As a result, educators must think creatively in order for material delivered to be understood through using interactive learning medium. This study intends to create a product in the form of interactive football multimedia for use in football courses as part of the learning process, particularly during the Covid-19 Pandemic. Materials and Methods . This study uses the research and development method developed by Borg and Gall. Where the stages are divided into 3, namely: (1) Pre-development stage, at this stage, conduct a needs analysis through a survey of the level of product needs for users, then prepare instruments and consult experts. (2) The development stage, developing a product that starts with designing the initial product and compiling the "Football Interactive Multimedia" script. Where in this study, there was a phase I trial of 30 students and a group II trial of 60 Medan State University Sports Science students. Furthermore, small group trials, stage I improvement, big group trials, stage II improvement, and mass production will be carried out. (3) The evaluation stage, product implementation, and product diffusion as a learning media tool for students. Results. The results showed that learning using interactive multimedia on soccer material is very good, with a percentage of 80%. The results obtained are due to the completeness of the material presented and the clarity of the material's explanation. where 15% said good and only 5% answered no. The results also show that the assessment of the media aspect gets a score of 4.46 or is included in the percentage of 80%. The results also show that the assessment of the media aspect scored 4.46 or entered the Very Good category. Furthermore, the material aspect has a score of 4.07, or in the Good category, and the learning aspect has a score of 4.36, or in the Very Good category. Next, the overall average score is 4.28, or in the Very Good category. Conclusions. It can be concluded from the results that the development of interactive multimedia ARA MODEL in soccer lectures is very feasible. Using interactive soccer multimedia as a learning model during a pandemic can increase students' understanding of basic techniques in soccer games.
Keywords: Interactive Media, Soccer, ARA MODEL, Learning Model