bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of Trust, Price, and Service Quality on Online Ojek Service Consumer Satisfaction in Sidoarjo Regency
Authors: Andriani Viya , Astuti Mudji
Published: January 2023

This study aims to determine the effect of trust, price and service quality on consumer satisfaction, either partially or simultaneously. , and to find out which of the variables Trust, Price and Service Quality have the most significant influence on consumer satisfaction for Go-Jek services based on Go-Food in Sidoarjo city. This research is a descriptive research using quantitative methods. The data collection technique is by distributing questionnaires to 100 consumer respondents who use Go-Food services in the city of Sidoarjo. The technique used in this research is multiple linear regression using SPSS (Statistical Package for Social Sciences) version 22 for windows. The results of this study prove that the trust variable has an effect on consumer satisfaction, the price variable has an effect on consumer satisfaction, and the service quality variable has an effect on consumer satisfaction for Gojek-based Go-Food services in the city of Sidoarjo.
The Effect of Brand Image and Product Quality on Fast Food Consumer Loyalty in East Java Province
Authors: Melania Dewi Riski , Sukmono Rita Ambarwati
Published: January 2023

This study aims to determine the effect of brand image and product quality on consumer loyalty at McDonald's in East Java. This study uses a quantitative approach with a questionnaire survey method. The method of determining the sample is simple random sampling. The sample used is 100 respondents who have bought McDonald's products in East Java. The data analysis used is outer model test and the inner model test on the Smart PLS software application. The results of this study indicate that there is an influence of brand image on consumer loyalty McDonald's in East Java, With the results of a good brand reputation indicator which dominantly reflects the brand image variable and the less dominant loyalty indicator reflects the brand image variable.  There is an effect of product quality on consumer loyalty McDonald's in East Java, with the result that the dominant flavor variant indicator reflects the product quality variable and the less dominant product shelf life indicator reflects the product quality variable.
The Influence of Service Quality, Company Image and Customer Relationship on Customer Satisfaction Expedition in Sidoarjo Regency
Authors: Kurniawan Ari Lista , Sari Dewi Komala
Published: January 2023

The results showed that: Service Quality affects Consumer Satisfaction of J&T express delivery. Kurniawan, Ari Lista. 2022. Effect of Service Quality, Company Image and Customer Relationship on Consumer Satisfaction of J&T Express Expedition Sidoarjo Regency. This study aims to determine the influence of Service Quality, Company Image and Customer Relationship on Consumer Satisfaction. This research a quantitative approach . Sampling in the study used accidental sampling techniques, with a total of 96 respondents from J&T Express Expedition consumers . Data collection techniques using questionnaires distributed throughquestionnaires. . Data analysis in this study includes validity test, reliability test, normality test, multicollinearity test, heteroscedasticity test, linearity test, auto correlation test, multiple linear regression analysis, T test, multiple correlation coefficient (R) and coefficient of determination (R2). Data processing in this study used the SPSS 22 (Statistical Program For the Social Sciences) software program. The results of the study indicate that service quality has an effect on consumer satisfaction with J&T express delivery. Company Image has an effect on customer satisfaction with J&T express delivery. Customer relationship hasan effect on customer satisfaction with J&T express delivery.
The Influence of Brand Ambassadors, Viral Marketing, and Online Customer Reviews on Purchase Decisions on Online Shopping Applications in Sidoarjo Regency
Authors: Akfinniha Rizki , Sari Dewi Komala
Published: January 2023

This study aims to determine the influence of Brand Ambassador, Viral Marketing, and Online Custommer Review on Purchasing Decisions. This research uses a quantitative approach. Sampling in the study using accidental sampling techniques, with the number of respondents as many as 100 respondents from marketplace shopee.id consumers. Data collection techniques using questionnaires distributed through questionaire. Data analysis techniques in this study use multiple linear regression analysis. Data processing in this study using the SPSS 22 (Statistical Program For the Social Sciences) software program. The result of this study, show result that can prove that Brand Ambassador has an affects on Purchasing Decisions of marketplace shopee.id, Viral Marketing, has an affects on Purchasing Decisions of marketplace shopee.id, and Online Custommer Review an affects of Purchasing Decisions for marketplace shopee.id user in Sidoarjo.
Analysis of the Influence of Organizational Culture, Job Satisfaction and Work Discipline on Employee Performance of Company
Authors: Nizar Rifqi Muchammad Wildan , Sumartik
Published: January 2023

This study aims to analyze and see the influence of organizational culture, job satisfaction and work discipline simultaneously and partially on employee performance at PT Prima Karya Teknik. And to see which of the organizational culture, job satisfaction and work discipline have the most significant effect on the performance of PT Prima Karya Teknik employees. The method used in this study uses a quantitative approach. The data collection technique was carried out by distributing questionnaires with a Likert scale measurement level, interviews and observations. The population in this study are all employees at PT Prima Karya Teknik, totaling 60 people. The sampling technique is saturated sampling technique, namely taking or determining the sample if all the population is used as a sample. The data obtained from the questionnaire was then processed using SPSS Version 22 software. The data analysis techniques used were validity test, reliability test, classical assumption test, multiple linear regression analysis, t test, f test and coefficient of determination test. Based on the analysis results show that organizational culture, job satisfaction and work discipline have a positive and significant effect both simultaneously and partially on the performance of PT Prima Karya Teknik employees. And the most significant variable on the performance of PT Prima Karya Teknik employees is the organizational culture variable.
The Leadership Role of Junior High School Principals in Maintaining Institutional Sustainability in the Covid-19 Era
Authors: Ahmad Ahmad , Haryanto Budi
Published: January 2023

This study aims to identify how the role of the head of SMP Muhammadiyah 10 Sidoarjo in maintaining the sustainability of the institution in the covid-19 era. In maintaining the sustainability of the institution in the covid-19 era, the principal must also have a role as a manager, which is conceptual by planning, solving problems at school, organizing and collaborating with school internal parties and the wider community. leader, leader or leader must be able to show himself as a leader and be able to give confidence to teachers and employees in carrying out their duties properly in the era of the Covid-19 pandemic. Innovators, school principals must provide new ideas to school residents in order to maintain the sustainability of the institution. The motivator for the COVID-19 pandemic situation, the principal hopes to always provide encouragement to teachers and employees in order to foster enthusiasm in helping the principal. Types of field research with qualitative research methods. The main sources and types of data are data taken directly from school principals, vice principals (wakasek), public relations, treasurers, teachers, and administration (TU). The data collection methods are observation, interview, interview and documentation. Researchers conducted data analysis with the stages of data reduction, presentation, conclusion drawing and the validity of the data. So, the conclusion of this study shows that the role of the head of SMP Muhammadiyah 10 Sidoarjo in maintaining the sustainability of the institution in the Covid-19 era is quite good because nothing is sacrificed.
The Influence of Transformational Leadership and Organizational Culture on Organizational Citizenship Behavior Through Organizational Commitment as an Intervening Variable
Authors: Fanani Achmad Muhajir , Abadiyah Rifdah
Published: January 2023

This study aims to determine the effect of Transformational Leadership and Organizational Culture on Organizational Citizenship Behavior through Organizational Commitment as an Intervening variable study PT. Moya Kasri Wira East Java. This research was conducted using quantitative methods with the sample used in this PT. Moya Kasri Wira East Java. This research used the program smartPLS 3.0.Based on the results of the analysis it can be concluded that Transformational Leadership has a significant effect on OCB, Organizational Culture has a significant effect on OCB, Transformational Leadership has a significant effect on Organizational Commitment, Organizational Culture has a significant effect on Organizational Commitment, Organizational Commitment has a significant effect on OCB, Transformayional Leadership has a significant effect on OCB trhough Oganizational Commitment, Organizational Culture has a significant effect on OCB trhough Organizational Commitment.
The Effect of Work Stress, Work Family Conflict, Organizational Climate, and Organizational Support Burn Out on Employee at Company
Authors: Iswahyuni Lujeng , Abadiyah Rifdah
Published: January 2023

This study aims to determine the effect of work stress, work family conflict, organizational climate and organizational support on burnout at PT. Welirang Tirta Mandiri. The analytical tool used is tabulating the questionnaire, collecting data in the form of validity and reliability tests. The hypothesis in this study is that there is the effect of work stress, work family conflict, organizational climate and organizational support on burnout. To test this hypothesis used data analysis tools in the form of multiple linear regression. The results of the research show that work stress, work family conflict, organizational climate, and organizational support has a positive effect on burnout. And simultaneously work stress, work family conflict, organizational climate and organizational support have a positive effect on burnout.
Effect Of Compensation, Job Satisfaction, and Organizational Commitment on Employee Performance
Authors: Khurniansyah Sirotjudin Arsyad , Andriani Dewi
Published: January 2023

Thissstudyyaimsstoodetermineetheeimpact offcompensation, jobbsatisfactionnanddorganizational commitmenttonnemployeeeperformanceeat theehospital. Thissresearch uses quantitative research using hypothesis testing. The sample used in this study were 85 nurses in the Surabaya area. The analytical tool used in this study uses statistical software. Thissstudyyaimsstoodetermineetheeimpact offcompensation, jobbsatisfactionnand organizational commitmenttonnemployeeeperformanceeat theehospital. The primary data in this study was originally based on a questionnaire. The results of the study explain that (1) compensation has an effect onnemployeeeperformance, (2) job satisfaction has an effect on employee performance, (3) organizational commitment has an effect on employee performance.
Exportación de leche de avena al mercado norteamericano (EE.UU), estado de California
Authors:   , Tomairo Pariona Bryan Luis , Sayas Gomez Edison , Sayas Gomez Lizet Yenifer , Camavilca Carhuaricra Brayan Jose
Published: January 2023

Este proyecto de bachiller tiene como título “Exportación de leche de avena al mercado norteamericano (EE. UU), Estado de california”. Es realizado para optar nuestro título universitario. Para realizar este proyecto tomaremos en cuenta lo aprendido con las clases de la universidad. Para dar inicio al proyecto con el Capítulo I, se describirá el análisis del entorno que consta del factor político, económico, social, ecológico y tecnológico; el sondeo de mercado local, así como también el análisis de la empresa que incluye la descripción del producto leche de avena, la segmentación del mercado americano y sobre la organización estudiada. En el capítulo II, se describe el plan estratégico de la organización que consta de la visión, misión, objetivos estratégicos y otros puntos más referentes al tema aborado. En el capítulo número 3, se describirá el plan de marketing que consta de los objetivos de marketing, marketing mix que incluye el diseño de la marca, la descripción del producto, y las estrategias de precio unitario, distribución de plaza, promoción, custumer service, así como una correcta atención al consumidor. Seguidamente, se describe el plan de operaciones en el cap. 4, que consta de los objetivos, así como las actividades concernientes a la producción. Posteriormente, se describe el diseño estructural y el plan de recursos en el capítulo V, que consta de las estrategias de reclutamiento, inducción y motivación. Seguidamente se describe el plan financiero en el capítulo VI, que consta de la historia financiera de la organización, el plan de transacciones, y estados financieros proyectados. Finalmente, se presenta el organigrama de OATMILK-EXPORT S.A.C.
Plan de negocio para la producción y comercialización de yogurt de pitahaya y endulzante de stevia, que ayuda a combatir problemas digestivos, diabetes y cáncer al colon en Lima metropolitana - 2022
Authors:   , Gomez Muñoz Jessica Lucero , Morales Quispe Rey Rogger , Sanabria Ratache Jasmin Ambar , Guizado Torres Angie Briguitte
Published: January 2023

Nuestro plan de negocio se dedicará a la producción y comercialización del yogurt de pitahaya con endulzante de stevia, un producto nacional que brindará aporte a una mejor alimentación y beneficio a la salud. Por otro lado, se realizó el estudio del PEST, con el objetivo de contar con más información del panorama global. La razón social de nuestro proyecto es "Yogu Dragón S.A.C.", teniendo como siguiente nombre comercial “Dragón Fruit”. Actualmente el consumidor peruano se encuentra enfocado en el cuidado de su alimentación y buscando formas de consumir productos más saludables y balanceados tomando conciencia de una vida con buena salud. Por otro parte, nuestro público objetivo en especial es para niños y adultos de la tercera edad de la cual estarán ubicados Lima metropolitana y en todo el Perú. Este producto ayuda a combatir sus problemas digestivos, diabetes y cáncer al colon, mejora la circulación de la sangre, es un antioxidante natural, regula la presión, contiene captina, vitamina C y regenera las células previniendo el envejecimiento. Por último, el plan de negocio será rentable porque se obtuvo un valor neto S/.2,996,398.10, de igual manera ocurre en la tasa interna de rentabilidad, dando como consecuencia 51%.
Cirugía de reposicionamiento labial: una revisión de la evolución de la técnica
Authors:   , Gonzales Medina Kelly Consuelo
Published: January 2023

La técnica de reposicionamiento de labios (LRT) se considera un tratamiento seguro y predecible de sonrisa gingival (GS). Sin embargo, desde que Rubinstein y Kostianovsky lo introdujeron en 1973, ha sufrido varias modificaciones. Este artículo tiene como objetivo revisar y proporcionar una recopilación histórica de la evolución de la técnica de reposicionamiento de labios (LRT) para ayudar a los médicos a comprender la descripción de cada técnica y la justificación de sus modificaciones para tratar el GS. Se realizó una búsqueda electrónica en Medline, Scopus y Cochrane Library hasta diciembre de 2020, que incluyó los términos "reposicionamiento de labios", "técnica de reposicionamiento de labios" o "cirugía de reposicionamiento de labios" y estudios que evalúan o discuten en detalle la modificación del LRT original. La búsqueda no tiene restricciones de idioma ni de tiempo. Además, se realizó una búsqueda manual de las referencias de todos los artículos incluidos. Las modificaciones descritas en la literatura incluyen rotura muscular, disección subperióstica de la encía, frenectomías y el uso de productos adyuvantes. Su objetivo es minimizar las recaídas, la morbilidad y mejorar la estabilidad. El malestar, la formación de cicatrices y el dolor fueron las complicaciones más frecuentes reportadas. La elección de utilizar una modificación debe analizarse y personalizarse de acuerdo con las necesidades individuales del paciente.
Nivel de conocimiento sobre salud bucal de madres con hijos en edad preescolar
Authors:   , Herrera Larico Leysi Karina
Published: January 2023

Introducción: Los niños en edad preescolar dependen de sus mamás para la prevención y control, cuidados en la higiene bucal y hábitos de alimentación; así como también en la frecuencia de visitas al odontólogo. Es por ello que el conocimiento de las mamás sobre salud bucal es un factor muy importante para permitir que sus hijos gocen de una buena salud bucal. Objetivo: Determinar el nivel de conocimiento sobre salud bucal de madres con hijos en edad preescolar que acuden a tres comités del programa vaso de leche de San Juan de Lurigancho (SJL). Materiales y métodos: Estudio observacional, descriptivo y transversal, cuya muestra fue de 130 madres con hijos en edad preescolar de tres comités del programa vaso de leche de SJL. El instrumento de evaluación fue un cuestionario validado de 20 preguntas sobre salud bucal, en la cual incluían preguntas sobre caries dental, dieta, prevención e higiene bucal. Los resultados fueron catalogados en muy bueno, bueno, regular y deficiente. Resultados: El 38.5% de las mamás presentó un nivel de conocimiento deficiente, mientras que el 29.2% obtuvo un resultado regular, el 22.3% obtuvo un resultado bueno y el 10% muy bueno. Conclusiones: El nivel de conocimiento sobre salud bucal de madres con hijos en edad preescolar que acuden al programa vaso de leche del distrito San juan de Lurigancho en el año 2021 fue deficiente.
Efecto del marketing digital en el incremento de ventas de la empresa Social Drinks E.I.R.L. en el año 2020
Authors:   , Martínez Mori Andrés
Published: January 2023

El presente estudio tuvo como objetivo determinar el efecto del marketing digital en el incremento de ventas una tienda de conveniencia en el año 2020. La metodología fue cuantitativa, aplicada, explicativa y no experimental. La población del estudio fue 100 clientes de la empresa, tomando como muestra la totalidad de la población. La técnica fue la encuesta y el instrumento el cuestionario. Los resultados reflejaron para el Marketing digital un 87,00% en nivel alto y un 13,00% en nivel medio, con respecto al Incremento de ventas obtuvo un 78,00% y nivel medio con un 22,00%. Asimismo, el valor de sig. ,000 por lo cual se acepta la hipótesis alterna y se rechaza la hipótesis nula, lo cual refleja que el marketing digital es positivo y facilitó el incremento de ventas de la empresa. Asimismo, el valor b fue de 7,81 indicado que este efecto alto. Se llegó a la conclusión de que el marketing digital tiene un efecto directo y positivo en el incremento de ventas de una empresa puesto que brinda la oportunidad de ampliar los canales de venta.
Características de la producción de aves en pequeños y medianos productores y su participación en el programa de control de la enfermedad de Newcastle
Authors:   , Nicho Alegre Nicole Daniella
Published: January 2023

La crianza a baja escala o a traspatio realizada por pequeños y medianos productores tiene como destino la generación de productos y subproductos animales para autoconsumo y venta del excedente producido. Las aves son las especies animales que principalmente se explotan con más frecuencia en estos sistemas productivos. En ese contexto, la investigación realizada tuvo como objetivo describir la producción avícola desarrollada por pequeños y medianos productores y la práctica de la vacunación contra la enfermedad de Newcastle, según se registró en la Encuesta Nacional Agropecuaria realizada por el Instituto Nacional de Estadística e Informática realizada el año 2019. La información extraída de las bases de datos fue analizada y resumida mediante estadística descriptiva. El estudio encontró que el promedio de aves criadas por productor a nivel nacional fue de 10.3 aves y los departamentos con mayor promedio de aves fueron Madre de Dios y Tacna. El 57.1% criaba entre 1 a 5 aves, 35% entre 6 a 20 aves, 7.2% entre 21 a 100 aves y solo el 0.3% criaba más de 100 aves. La distribución de los productores fue mayor en la región de la Sierra (45.5%) y Selva (37.2%). El tipo de aves que más criaban fueron gallinas (44.4%), gallos (31.9%) y pollos (15.0%). El 68.7% de encuestados mencionó que vacunaban contra la enfermedad de Newcastle. El 79.7% lo hacía con el Servicio Nacional de Sanidad Agraria, 15.5% con otros profesionales independientes y 4.8% con cualquiera de ellos. El estudio aporta información que puede contribuir al control de enfermedad y la mejora de las condiciones de la producción avícola entre pequeños y medianos productores.
WITHDRAWN: Stage-wise adaptive differential evolution algorithm and its applications
Authors: Wang Lifang , Zhang Zhe , Guo Xiaodong
Published: January 2023

Common improvement strategies of differential evolution algorithms include improving the difference vector and the basis vector based on the characteristics of the operator, and using fixed parameters, but in different evolutionary periods, they cannot enhance the solving accuracy effectively, resulting in poor solving accuracy of the algorithm and easily trapping into local optimum. In this paper, we raise a stage-wise adaptive differential evolution algorithm (SDDE), which gives two evolution strategies based on the characteristics of each evolutionary period during the iteration of the evolutionary algorithm. The learning factor (F) and the crossover probability (CR) as well as the adaptive adjustment scheme for the population size NP are given to balance the global and local search ability of the algorithm so as to improve the solving accuracy of the algorithm. In addition, an interference mechanism is introduced in the later stage of the algorithm to accelerate the convergence of the algorithm while avoiding falling into local optima. In this paper, the algorithm is experimentally compared with five other improved algorithms on thirty benchmark functions.The results show that SDDE has better convergence performance than the other five algorithms. Applying SDDE to the parameter estimation problem of FM acoustic waves, the results show that SDDE achieves more accurate results than the other five algorithms.
The Image Survival and Protection of Intangible Cultural Heritage in the New Media Environment
Authors: Wang Jinxia
Published: January 2023

As a product of agricultural civilization, intangible cultural heritage (ICH) has been in a bad situation in recent years. Modern video media, with the dual identity of art and media, is an effective way to preserve and disseminate ICH. First, a hybrid network composed of a Bi-directional Long Short-Term Memory (Bi-LSTM) network with attention structure and Neural Network is adopted to extract relevant knowledge. Then, the generative adversarial network (GAN) is optimized. Lastly, this model is tested. The test results reveal that in the dataset constructed here, when the resolution of the processed image is 48×64×48, it takes 0.4825s for the unimproved GAN to process the image, while the algorithm improved only needs 0.0391s to process the image, with a speedup of 12.2.
Near-infrared cholangiography can increase the chance of success in laparoscopic approaches to common bile duct stones, even with previous abdominal surgery
Authors: Tzeng Wei-Juo , Lin Yu-Hung , Hou Teng-Yuan , Yin Shih-Min , Lin Yu-Cheng , Liu Yueh-Wei , liu yu yin , Li Wei-Feng , Wang Chih-Chi , Marescaux Jacques , Diana Michele
Published: January 2023

BackgroundThe treatment of common bile duct (CBD) stones with minimally invasive surgery (MIS) mandates is more technical demanding than laparoscopic cholecystectomy (LC), especially in patients with a history of previous abdominal surgery, cholangitis or cholecystitis. Near-infrared (NIR) cholangiography via systemic or biliary tree administration of indocyanine green (ICG), which enhances the visualization of the biliary tree anatomy, may increase the reassurance of CBD localization. The aim of this study was to identify the benefit of near-infrared cholangiography for laparoscopic common bile duct exploration (LCBDE).MethodsThree groups of CBD stone patients were included in this retrospective study depending on the surgical methods: 1) open choledocholithotomy (OCC), 2) laparoscopic choledocholithotomy (LCC), and 3) near-infrared cholangiography-assisted laparoscopic choledocholithotomy (NIR-CC). For the NIR-CC group, either 3 ml (concentration: 2.5 mg/mL) of ICG were intravenously administered or 10 ml (concentration: 0.125 mg/mL) of ICG were injected directly into the biliary tree. The enhancement rate of the cystic duct (CD), CBD, the upper and lower margin of the CBD were compared using white light imageResultsA total of 187 patients with a mean age of 68.26 years were included (OCC, n = 56; LCC, n = 110; NIR-CC, n = 21). The rate of previous abdominal surgery was significantly lower in the LCC group. The conversion rate was similar between the LCC and the NIR CC groups (p = 0.746). The postoperative hospital stay was significantly longer in the OCC group. No differences in morbidity and mortality were found between the three groups. In the NIR-CC group, the localization of CBD was as high as 85% compared to 24% with white light imaging.ConclusionsNear-infrared cholangiography helps increase the chance of success in minimally invasive approaches to CBD stones even in patients with previous abdominal surgeries, without increasing the rate of conversion.
Probing the Chemical "Reactome" with High Throughput Experimentation Data
Authors: King-Smith Emma , Berritt Simon , Bernier Louise , Hou Xinjun , Klug-McLeod Jacquelyn , Mustakis Jason , Sach Neal , Tucker Joseph , Yang Qingyi , Howard Roger , Lee Alpha
Published: January 2023

High-throughput experimentation (HTE) has the potential to improve our understanding of organic chemistry by systematically interrogating reactivity across diverse chemical spaces. Notable bottlenecks include few publicly available large-scale datasets and the need for facile interpretation of these data's hidden chemical insights. Herein we report the development of a High Throughput Experimentation Analyzer (HiTEA), a robust and statistically rigorous framework which is applicable to any HTE dataset regardless of size, scope, or target reaction outcome. We improve the HTE data landscape with the disclosure of 47,000 + previously proprietary HTE reactions. HiTEA is validated on this dataset, showcasing the elucidation of hidden relationships between reaction components and outcomes as well as highlighting reaction space that necessitates further investigation.
Fast Armijo line search for stochastic gradient descent
Authors: Hafshejani Sajad Fathi , Gaur Daya , Hossain Shahadat , Benkoczi Robert
Published: January 2023

We give an improved non-monotone line search algorithm for stochastic gradient descent (SGD) for functions that satisfy interpolation conditions. We establish theoretical convergence guarantees for the algorithm for strongly convex, convex and non-convex functions. We conduct a detailed empirical evaluation to validate the theoretical results.
A Rare Case of Superior Mesenteric Artery Thrombosis Post Vaginal Delivery
Authors: Aravindan Anila , Bondili Anupama
Published: January 2023

Introduction: Acute abdominal pain following a vaginal delivery is rare. Various causes of severe acute postpartum abdominal pain include, pelvic infection, thrombophlebitis, ovarian venous thrombosis, acute urinary retention. Mesenteric vessel thrombosis is an uncommon but often fatal form of intestinal ischemia.
Case presentation: Our case describes a 35 years old grand multipara presented three weeks after spontaneous vaginal delivery with severe abdominal pain, abdominal distension, and hematemesis of acute onset. No significant medical history. Past surgical history of bariatric surgery two years back. The patient’s hemodynamic state was unstable and was diagnosed with superior mesenteric artery thrombosis by contrast-enhanced computed tomography and had urgent laparotomy and resection of the bowel segment with the temporary closure of the abdomen. On the next day a second look laparotomy was done later reversal of Roux en Y gastric bypass (gastro-gastric anastomosis, jejuno-jejunal anastomosis, and jejuno-ileal anastomosis), appendectomy was carried out. She was discharged on the 10th day of admission in stable condition with regular follow-up in the surgical outpatient department.
Conclusion: Even after vaginal birth, pregnancy and puerperium raise the risk of thrombosis. Given that this is frequently discovered at a late and irreversible stage, an increased index of suspicion is required for an early diagnosis and rapid therapy to enhance the maternal prognosis. To lower maternal mortality, risk assessments for thromboembolism must be made periodically. To rule out mesenteric artery ischemia in cases of acute abdominal discomfort, abdominal contrast-enhanced computed tomography may be required.
Study on Fuzzy Fractional European Option Pricing Model with Mittag-Leffler Kernel
Authors: Hashemi Hebatollah , ezzati reza , Mikaeilvand Naser , Nazari Mojtaba
Published: January 2023

We investigate the fuzzy fractional European option pricing models in the sense of the fuzzy AtanganaBaleanu derivative in this paper. The paper’s main contribution is the analysis of the existence and uniqueness of the fuzzy European-type option pricing model that provides a fundamental solution. Moreover, we set up a new scheme for approximating solutions of this model based on fuzzy homotopy perturbation transform method. This procedure is used successfully on two examples for finding the solutions
Water-induced mantle overturns leading to the origination of Archean continents and sub continental lithospheric mantle
Authors: Wu Zhongqing , Song Jian , Zhao Guochun , Pan Zhongxu
Published: January 2023

The originations of the Archean continents and sub continental lithospheric mantle (SCLM) were most important events in the early Earth and crucial for understanding how the early Earth worked. The mechanisms for the originations of the Archean continents and SCLM remain unclear. This study suggests that these events were controlled by a deep-water cycle (DWC) in the early Earth. With the solidification of the basal magma ocean (BMO), water in the BMO moved toward the core-mantle boundary and the BMO eventually became gravity unstable because of the enrichment of water. The gravity instability triggered the massive mantle overturns and transported a huge amount of water upward to the shallow part of the Earth. The massive overturn events resulted in the major pulses of the thick SCLM and continental crust generations in the Neoarchean. The DWC model in the early Earth can account for the episodic feature of continental growth and why TTG and thick SCLM basically occurred in the Archean. The DWC model also shows why only the Earth among inner solar system planets was covered with the continental crust. Our results suggest that the DWC played a first-order role in the evolution and dynamics of the early Earth just like the current DWC driven by the plate tectonics on the nowadays Earth.
BLM helicase determines chemotherapy-induced responses of human glioma cells and shifts between apoptosis, senescence or polyploidy
Authors: Wojnicki Kamil , Kaczmarczyk Agnieszka , Wojtas Bartosz , Kaminska Bozena
Published: January 2023

Most of anti-tumour therapies eliminate neoplastic cells by introducing DNA damage which ultimately triggers cell death. These effects are counteracted by activated DNA repair pathways and RECQL family helicases, including BLM, participate in replication stress, DNA damage and repair. Glioblastoma (GBM) is a common, malignant brain tumour that inevitably recurs despite surgical resection, radiotherapy, and chemotherapy with temozolomide (TMZ). Expression and functions of the BLM helicase in therapy resistant GBMs have not been elucidated. We analysed expression and localisation of BLM in human gliomas and several glioma cell lines using TCGA datasets, immunostaining and Western blotting. BLM depleted human glioma cells were generated with CRISPR/Cas9. Effects of chemotherapeutics on cell proliferation, DNA damage and apoptosis were determined with flow cytometry, immunofluorescence Western blotting and RNA sequencing. We found upregulated BLM mRNA levels in malignant gliomas, increased cytosolic localisation and poor survival of BLM highly expressing GBM patients. BLM deficiency in LN18 and LN229 glioma cells resulted in profound transcriptomic alterations, reduced cell proliferation, and altered cell responses to chemotherapeutics. BLM-deficient glioma cells were resistant to the TMZ and PARP inhibitor treatment and underwent polyploidy or senescence depending on the TP53 activity. These dependencies were not detected in RECQL4-deficient cells. Our findings of high BLM expression in GBMs and its roles in responses to chemotherapeutics provide a rationale for targeting BLM helicase in those tumours. BLM deficiency affects responses of glioma cells to chemotherapeutics targeting PARP-1 dependent pathways, while these effects are not detected in RECQL4 deficient cells implying distinct functions of these helicases.
Bioinformatics Identification of Ferroptosis-related Genes and Therapeutic Drugs in Rheumatoid Arthritis
Authors: Li Xianbin , He Andong , Liu Yue , Huang Yuye , Zhang Xueli
Published: January 2023

Objectives
Rheumatoid arthritis (RA) is a chronic immune disease characterized by synovial inflammation and bone destruction, with a largely unclear etiology. Evidences have indicated that ferroptosis may play an increasingly important role in the onset and development RA. However, ferroptosis-related genes are still largely unexplored in RA. Therefore, this work focused on identifying and validating the potential ferroptosis-related genes involved in RA through bioinformatics analysis.
Methods
We screened differentially expressed ferroptosis-related genes (DEFGs) between RA patients and healthy individuals based on GSE55235 dataset. Subsequently, correlation analysis, protein-protein interaction (PPI) network analysis, GO, and KEGG enrichment analyses were performed using these DEFGs. Finally, our results were validated by GSE12021 dataset.
Results
We discovered 34 potential DEFGs in RA based on bioinformatics analysis. According to functional enrichment analysis, these genes were mainly enriched in HIF-1 signaling pathway, FoxO signaling pathway, and Ferroptosis pathway. Four genes (GABARPL1, DUSP1, JUN, and MAPK8) were validated to be downregulated by GSE12021 dataset and may be possible diagnostic biomarkers and therapeutic targets for RA via the regulation of ferroptosis.
Conclusions
Our results may help shed more light on the pathogenesis of RA. Ferroptosis-related genes in RA could be valuable diagnostic biomarkers and they will be exploited clinically as therapeutic targets in the future.
Soft Actor Critic (SAC) based Automatic Policy Generation and Effective Framework for Dynamic Trust Management for Securing SDN
Authors: S Sahana D , H Brahmananda S
Published: January 2023

The Software Define Network (SDN) integrated with Internet of Things (IoT) reduces the scalability of IoT devices by managing the network, however the SDN are easily vulnerable to attacks as they used centralized controller for managing the network which can be easily manipulate by the attackers. The existing approaches focused on secure access control to the SDN controller but limits with controller scalability and trust management. By leveraging the problems in existing works, we propose SDMAC-Secure DynaMic Access Control framework which improves the security and provide efficient services to entities. Initially, all the users and applications are registered with attributes based on the registration, the authentication is performed to ensure the legitimacy. The policies are generated for the legitimate users by using Soft Actor Critic (SAC) which considers attributes, actions permitted, and temporal features to enhance network security, the conflicts between the policies are reduced by validating and storing the policies to database by the administrator. The proposed work is validated using iFog Sim tool and the performance comparisons between proposed and existing works are validated with several metrics. The simulation result shows that the proposed model work outperforms better than existing works.
Optimal thermodynamic conditions to minimize kinetic byproducts in aqueous materials synthesis
Authors: Wang Zheren , Sun Yingzhi , Cruse Kevin , Zeng Yan , Fei Yuxing , Liu Zexuan , Shangguan Junyi , Byeon Young-Woon , Jun KyuJung , He Tanjin , Sun Wenhao , Ceder Gerbrand
Published: January 2023

Thermodynamics has strong predictive power for materials synthesis by identifying the stability region of target phases, but does not give explicit information about the relative competitiveness of undesired byproduct phases in synthesis. In this work, we propose a quantitative and computable measure to guide the selection of synthesis conditions. Defining thermodynamic competition as the difference in driving force between a target phase and its competing phases, we hypothesize that phase-pure synthesis becomes more likely when this thermodynamic competition is minimized. We systematically validate this hypothesis with two approaches: (1) we analyze large-scale solution synthesis procedures as text-mined from the literature, and show that experimentally-optimized synthesis conditions are near the predicted thermodynamic optimum point, and (2) direct experimental evaluation of synthesis in LiIn(IO3)4 and LiFePO4, which show that phase-pure synthesis occurs only when thermodynamic competition is minimized. Our work demonstrates that a quantitative assessment of thermodynamic competition is an effective descriptor for synthesis optimization and a promising tool for optimizing aqueous solution-based experimental synthesis conditions.
WITHDRAWN: Development and validation of a distress measurement for insulin injections among patients with diabetes
Authors: Choi Eujin , Kim Min-Sun , Cho Juhee , Kim Soohyun , Kwon Eun Kyung , Kim Youngha , Kang Danbee , Cho Sung Yoon
Published: January 2023

Background: Insulin injections are stressful but necessary for people with diabetes. This study aimed to develop and validate the Distress of Self-Injection (DSI) scale for patients with diabetes aged ≥10 years.
Methods: We created a questionnaire to evaluate DSI after examining each item following a literature review. The DSI scale with 20 questions in three domains (physical [4], psychosocial [7], and process [9]) was developed and tested at the Samsung Medical Center in Seoul, Korea, from April to September 2021. To verify structural validity, exploratory and confirmatory factor analyses (CFA) were conducted. Internal consistency was also calculated. To assess construct and criterion validity, the correlation between the DSI scale and Korean version of the Problem Areas in Diabetes (PAID-K) scale was obtained.
Results: Cronbach’s alpha varied from 0.69 to 0.87, and the DSI score was 0.90, demonstrating acceptable internal consistency. CFA fit indices (CFI = 0.868; SRMR = 0.080) were favorable. DSI and pertinent PAID-K domains correlated strongly. For measuring self-injection distress, the DSI score had good accuracy.
Conclusions: For patients with diabetes aged ≥10 years who self-inject insulin, the DSI was a viable and accurate method for quantifying discomfort associated with insulin injection. Health practitioners should use the DSI to communicate with patients about their suffering.
Partnership between bees and flowers: Fine-tuned feeding speed and nectar sugar concentration facilitate energy rewards and pollination service
Authors: Wu Jianing , Sun Yu , Liang Zhanhao , Tan Shiyong , Wu Zhigang , Pan Zhao
Published: January 2023

The interaction between bee pollinators and flowering plants lays the foundation of biodiversity and food production for human livelihoods, with three out of four crops worldwide relying on this interaction. The ongoing success of this mutualism is pow-ered by the bilateral and potentially dueling demands of food procurement for polli-nators and sexual reproduction for plants. However, the underlying mechanisms of the mutualism, which must simultaneously fulfil the requirements from both sides, remain unexplored. Here we establish a biomechanical framework that combines la-boratory tests and mathematical models to investigate the relationship between bees and plants, using the feeding speed of bees and the nectar sugar concentration of flowers as the core factors. We find that both the optimal frequency of a bee dipping nectar and the nectar sugar concentration are delicately balanced over narrow ranges to simultaneously satisfy demands of both parties of the mutualism. Human activities and climate change can perturb this balanced interaction, which would be detri-mental to this critical pollination system essential to staple crops around the world.
ALPK1 regulates Synovitis in the Temporomandibular Joint via Promoting Nuclear PKM2-Mediated M1 Macrophage Polarization
Authors: Zhao Jie , Feng Yaping , Liu Xin , Li Huimin , Guo Huilin , Ke Jin , Long Xing
Published: January 2023

ALPK1 (Alpha-kinase 1) was shown to be expressed on macrophages and associated with a variety of inflammatory diseases. The goal of this study was to clarify whether ALPK1 activation influences macrophage polarization, inducing inflammatory cytokine release and then contributes to synovial inflammation of TMJ. This study demonstrated that ALPK1 was highly upregulated not only in the synovial fluid of patients with TMJ synovitis, but also in the inflamed TMJ synovium of patients, especially located in synovial macrophages. Furthermore, ALPK1 knockout mice exhibited limited infiltration of macrophages and decreased expression levels of M1 macrophage-associated genes in CFA-induced TMJ inflammation. Meanwhile, our in-vitro study demonstrated that recombinant human ALPK1 (rhALPK1) could promote the expression of INOS, CD86, TNF-α, IL-1β and IL-6, and nuclear translocation of PKM2 in RAW264.7 cells. Besides, one of PKM2 agonists, DASA-58, significantly reversed the enhanced production of INOS, CD86, TNF-α, IL-1β and IL-6 induced by rhALPK1 in these cells. Collectively, we identified that the ALPK1 could regulate M1 macrophage polarization via promoting nuclear translocation of PKM2 and thereby contributing to development of TMJ synovitis.
Impact of Covid-19 on access to paediatric surgery in Teso sub-region, Eastern Uganda
Authors: Ajiko Mary margaret Ajiko , Ekblad Solvig , Ocen Innocent , Wange Aaron Edward , Nordin Pär , Wladis Andreas , Löfgren Jenny
Published: January 2023

The COVID-19 pandemic posed a significant threat to healthcare systems worldwide. Efforts to contain the pandemic, including lock-down and cancellation of elective surgery, increased barriers to healthcare. Its impact on the access to surgical care of children in less resourced contexts is not known. This study investigated how paediatric surgical services was affected during the pandemic in the Teso sub-region in Eastern Uganda. Data were collected from theatre logbooks about surgical activity before and during the pandemic (2019–2021). Data about health workers’ and parents’ experience of how access to surgical service for children was affected during the Covid-19 pandemic were collected through interviews. Total surgical procedures for children increased by 24% between 2019 (n = 1407) and 2021 (n = 1751). Procedures performed for pregnancy-related conditions increased most (58.3% increment). 12 parents and 25 health workers participated in the interviews. Using reflexive thematic analysis, two themes emerged. A reduction of surgical service delivery was expected as barriers to surgical care increased in several ways. However, the number of surgical procedures performed increased compared to before the pandemic. Many lessons were learned, and health care system was reinforced. This is an important momentum for building a resilient health care system for future challenges.
Decision makers find it difficult to compare and select similar systematic reviews based on quality, methods and results: a cross-sectional survey
Authors: Lunny Carole , Whitelaw Sera , Chi Yuan , Zhang Jia He , Ferri Nicola , Kanji Salmaan , Pieper Dawid , Shea Beverley , Dourka Jasmeen , Veroniki Areti Angeliki , Arden Clare L , Pham Ba' , Reid Emma K , Bagheri Ebrahim , Tricco Andrea C
Published: January 2023

Background
Systematic reviews (SRs) are being published at an accelerated rate. Decision makers are often faced with the challenge of comparing and choosing between multiple SRs on the same topic. We surveyed individuals in the healthcare field to understand what criteria they use to compare and select one or more SRs from multiple on the same topic.
Methods
We developed a survey with 21 open and closed questions. We disseminated it through social media and professional networks.
Results
Of the 684 respondents, 25% were health practitioners, 9% policymakers, 39% researchers, and 13% were students. Policymakers, practitioners and researchers frequently sought out SRs (98.1%) as a source of evidence to inform decision making. They frequently (97.7%) found more than one SR on a given topic of interest to them. Half (50%) struggled to choose the most valid and trustworthy SR amongst multiple. These difficulties related to lack of time (55.2%), insufficient skills/ experience in quality appraisal (27.7%), and difficulty comparing different SRs (54.3%). Respondents compared SRs based on: relevance to their question of interest; its methodological quality, and recency of SR search date.
Conclusions
The exponential growth in the number of SRs leads to duplication of research on similar questions and compounds the problem of identifying which evidence is of the highest quality for decision makers. Failure to critically appraise and choose the highest quality SRs means that practice and policy decisions may not reflect the best evidence, the implementation of better intervention strategies is delayed, and patients may unduly suffer.