bluuebunny/crossref_metadata_2025 huggingface dataset:
Areal Surface Roughness of AZ31B Magnesium Alloy Processed by Dry Face Turning: An Experimental Framework Combined with Regression Analysis
Authors: Gao Honghong , Ma Baoji , Singh Ravi Pratap , Yang Heng
Published: May 2020

Surface roughness is used to quantitatively evaluate the surface topography of the workpiece subjected to mechanical processing. The optimal machining parameters are critical to getting designed surface roughness. The effects of cutting speed, feed rate, and depth of cut on the areal surface roughness of AZ31B Mg alloys were investigated via experiments combined with regression analysis. An orthogonal design was adopted to process the dry turning experiment of the front end face of the AZ31B bar. The areal surface roughness Sa and Sz of the end face were measured with an interferometer and analyzed through direct analysis and variance analysis (ANOVA). Then, an empirical model was established to predict the value of Sa through multiple regression analysis. Finally, a verification experiment was carried out to confirm the optimal combination of parameters for the minimum Sa and Sz, as well as the availability of the regression model for predicting Sa. The results show that both Sa and Sz of the machined end face reduce with the decrease in feed rate. The minimum of Sa and Sz reaches to 0.577 and 5.480 µm, respectively, with the cutting speed of 85 m/min, the feed rate of 0.05 mm/rev, and a depth of cut of 0.3 mm. The feed rate, depth of cut, and cutting speed contribute the greatest, the second and the smallest to Sa, respectively. The linear regression model can predict Sa of AZ31B machined with dry face turning, since the cutting speed, feed rate and depth of cut can explain 97.5% of the variation of Sa.
Intensive Ways of Producing Carbonate Curing Building Materials Based on Lime Secondary Raw Materials
Authors: Lyubomirskiy Nikolai , Bakhtin Aleksandr , Fic Stanisław , Szafraniec Małgorzata , Bakhtinа Tamara
Published: May 2020

The article is dedicated to the research and development of intensive methods for curing products by capturing and binding CO2. It aims to improve and increase the productivity of technologies for the production of artificially carbonated building materials and products. Soda production wastes, limestone dust and finely dispersed limestone dust were used as the research objects. Secondary raw materials have been investigated using modern methods of phase composition and granulometry test. Intensive methods of production of accelerated carbonation of systems consisting of soda wastes were tested using multi-parameter optimization methods. The effects of recycled lime materials on the strength and hydrophysical properties of the obtained material were determined. The secondary raw materials effect depended on the composition of the raw mixture, molding conditions, CO2 concentration applied to the carbonate curing chamber, and the duration of exposure to environments with high CO2 content. It was found that the most effective way of providing accelerated carbonation curing of construction materials and products is a combined carbonation method, combining the principles of dynamic and static methods. It was concluded that the optimal CO2 concentration in the gas-air mixtures used for carbonate curing is 30%–40%.
Volumetric Changes in Morse Taper Connections After Implant Placement in Dense Bone. In-Vitro Study
Authors: Romanos Georgios E. , Delgado-Ruiz Rafael Arcesio , Nicolas-Silvente Ana I.
Published: May 2020

The stability of the implant–abutment interface is crucial for the maintenance of the implant index integrity. Several factors are capable of inducing deformation in implant–abutment connection, such as the actual insertion of the implant into the bone. This study aimed to evaluate the deformations produced in the connection after the insertion of the implant. Ten implants with two different implant carriers (Type A: carrier attached to platform and Type B: carrier attached inside the index-connection) were placed in artificial Type II bone, and volumetric changes were evaluated for different connection features with a 3D digital microscope. ANOVA (analysis of variance), Wilcoxon, and Tukey HSD post-test were used for statistical comparisons. Type A implants presented deformation at the platform level (inner slot angles and slot width), but no volumetric changes were observed inside the connection. Type B implants presented deformation in three parameters inside the connection (outer channel length, coronal step width, and coronal step length). Within the limitations of this study, we can conclude that more deformation is expected at the internal connection when the implant carrier engages this area. The engagement area should be as far away as possible from the index connection.
Reliability and Lifetime Assessment of Glider Wing’s Composite Spar through Accelerated Fatigue Life Testing
Authors: Zaharia Sebastian Marian , Pop Mihai Alin , Udroiu Răzvan
Published: May 2020

The evaluation of the reliability and the lifetime of aerospace components has become an important segment of the design stage. The aeronautical components are subjected to complex, rigorous tests and have a long test life. The main goal in the field of aviation is to have components with high reliability and quality and to meet the mandatory requirements and regulations. The spars are stiffening components positioned along the wing and which take up most of the load and are tested for fatigue over a long period of time. The spar which was analysed in this study has a sandwich structure with GFRP (glass fiber reinforced plastic) skin and foam core. In this paper, the performances in the static and dynamic conditions of the GFRP-foam sandwich structures cut out of the composite spar of a glider were analysed. Additionally, using accelerated techniques based on the three-point fatigue bending test, the main reliability indicators of the GFRP-foam sandwich structures were determined. Using the statistical processing of the experimental data and the Inverse Power Law–Weibull acceleration model, the mean number of cycles to failure, in normal testing conditions of the GFRP-foam specimens was determined, with a value of 102,814. Using the accelerated testing techniques of the GFRP-foam sandwich structures an important decrease of the test time (8.43 times) was obtained.
Towards Deterministic Computation of Internal Stresses in Additively Manufactured Materials under Fatigue Loading: Part I
Authors: Awd Mustafa , Labanie Mhd Fateh , Moehring Kerstin , Fatemi Ali , Walther Frank
Published: May 2020

The ongoing studies of the influence of internal defects on fatigue strength of additively manufactured metals adopted an internal crack or notch-like model at which the threshold stress intensity factor is the driving mechanism of fatigue failure. The current article highlights a shortcoming of this approach and offers an alternative based on X-ray microcomputed tomography and cyclic plasticity with a hybrid formulation of Chaboche and Armstrong–Frederick material laws. The presented tessellation and geometrical transformation scheme enabled a significantly more realistic morphological representation of internal defects that yielded a cyclic strain within 2% of the experimental values. This means that cyclic plasticity models have an accurate prediction of mechanical properties without repeating a full set of experiments for additively manufactured arbitrary microstructures. The coupling with a material law that is oriented towards the treatment of cyclic hardening and softening enabled more accurate computation of internal stresses under cyclic loading than ever before owing to the maturity of tessellation and numerical tools since then. The resulting stress–strain distributions were used as input to the Fatemi–Socie damage model, based on which a successful calculation of fatigue lifetime became possible. Furthermore, acting stresses on the internal pores were shown to be more than 450% concerning the applied remote stress amplitude. The results are a pretext to a scale bridging numerical solution that accounts for the short crack formation stage based on microstructural damage.
Design and Manufacturing of a Nd-Doped Phosphate Glass-Based Jewel
Authors: Pugliese Diego , Gobber Federico Simone , Forno Ilaria , Milanese Daniel , Actis Grande Marco
Published: May 2020

This paper reports the results of the designing, manufacturing and characterization of a jewel obtained by means of coupling the dogmas of industrial design to the analytical engineering approach. The key role in the design of the jewel was played by an in-house synthesized Neodymium (Nd)-doped phosphate glass, selected due to its easy handling and capability to change color according to the incident light wavelength. The glass core was covered by a metal alloy to mitigate its relatively high fragility and sensitivity to thermal shock and, at the same time, to highlight and preserve its beauty. The selection of the proper metal alloy, having thermo-mechanical properties compatible with those exhibited by the glass, was carried out by means of Ashby’s maps, a powerful tool commonly adopted in the field of industrial design.
AHP-Like Matrices and Structures—Absolute and Relative Preferences
Authors: Koloseni David , Helldin Tove , Torra Vicenç
Published: May 2020

Aggregation functions are extensively used in decision making processes to combine available information. Arithmetic mean and weighted mean are some of the most used ones. In order to use a weighted mean, we need to define its weights. The Analytical Hierarchy Process (AHP) is a well known technique used to obtain weights based on interviews with experts. From the interviews we define a matrix of pairwise comparisons of the importance of the weights. We call these AHP-like matrices absolute preferences of weights. We propose another type of matrix that we call a relative preference matrix. We define this matrix with the same goal—to find the weights for weighted aggregators. We discuss how it can be used for eliciting the weights for the weighted mean and define a similar approach for the Choquet integral.
Effects of Intense Pulsed Light (IPL) Rapid Annealing and Back-Channel Passivation on Solution-Processed In-Ga-Zn-O Thin Film Transistors Array
Authors: Kim Hyun Jae , Han Chul Jong , Yoo Byungwook , Lee Jeongno , Lee Kimoon , Lee Kyu Hyoung , Oh Min Suk
Published: May 2020

We report on the effects of the intense pulsed light (IPL) rapid annealing process and back-channel passivation on the solution-processed In-Ga-Zn-O (IGZO) thin film transistors (TFTs) array. To improve the electrical properties, stability and uniformity of IGZO TFTs, the oxide channel layers were treated by IPL at atmospheric ambient and passivated by photo-sensitive polyimide (PSPI). When we treated the IGZO channel layer by the IPL rapid annealing process, saturation field effect mobility and subthreshold swing (S.S.) were improved. And, to protect the back-channel of oxide channel layers from oxygen and water molecules, we passivated TFT devices with photo-sensitive polyimide. The IGZO TFTs on glass substrate treated by IPL rapid annealing without PSPI passivation showed the field effect mobility (μFE) of 1.54 cm2/Vs and subthreshold swing (S.S.) of 0.708 V/decade. The PSPI-passivated IGZO TFTs showed higher μFE of 2.17 cm2/Vs than that of device without passivation process and improved S.S. of 0.225 V/decade. By using a simple and fast intense pulsed light treatment with an appropriate back-channel passivation layer, we could improve the electrical characteristics and hysteresis of IGZO-TFTs. We also showed the improved uniformity of electrical characteristics for IGZO TFT devices in the area of 10 × 40 mm2. Since this IPL rapid annealing process could be performed at a low temperature, it can be applied to flexible electronics on plastic substrates in the near future.
Effect of Intra-Ply Hybrid Patches and Hydrothermal Aging on Local Bending Response of Repaired GFRP Composite Laminates
Authors: Andrew J. Jefferson , Arumugam Vellayaraj , Dhakal Hom N.
Published: May 2020

This study investigates the influence of intra-ply hybrid patches and hydrothermal aging on the indentation properties of patch repaired GFRP composites. Fabrics with various proportions of glass and Kevlar fibers were employed as the patches to achieve enhanced mechanical properties by hybridizing Kevlar and glass fibers together. Hydrothermal aging behavior of repaired composite laminates modified with water-resistant glass fibers in the outer layers was further investigated. Specimens were immersed in an environmental chamber containing seawater at temperatures of 30 (ambient), 50, and 70 °C until up to saturation. Damage mechanisms of repaired laminates were monitored using real-time acoustic emission (AE) technique. The experimental results showed that specimens repaired with 50G:50K patches offered superior performance than the virgin specimens. The hydrothermal aging effect on indentation behavior of the modified repaired specimens showed a considerable reduction in indentation properties, with higher strength retention exhibited by the repaired specimens modified with chopped glass fibers compared to the particulate fibers.
Identification of the Volatile Components of Galium verum L. and Cruciata leavipes Opiz from the Western Italian Alps
Authors: Tava Aldo , Biazzi Elisa , Ronga Domenico , Avato Pinarosa
Published: May 2020

The chemical composition of the volatile fraction from Galium verum L. (leaves and flowers) and Cruciata laevipes Opiz (whole plant), Rubiaceae, was investigated. Samples from these two plant species were collected at full bloom in Val di Susa (Western Alps, Turin, Italy), distilled in a Clevenger-type apparatus, and analyzed by GC/FID and GC/MS. A total of more than 70 compounds were identified, making up 92%–98% of the total oil. Chemical investigation of their essential oils indicated a quite different composition between G. verum and C. laevipes, both in terms of the major constituents and the dominant chemical classes of the specialized metabolites. The most abundant compounds identified in the essential oils from G. verum were 2-methylbenzaldheyde (26.27%, corresponding to 11.59 μg/g of fresh plant material) in the leaves and germacrene D (27.70%; 61.63 μg/g) in the flowers. C. laevipes essential oils were instead characterized by two sesquiterpenes, namely β-caryophyllene (19.90%; 15.68 μg/g) and trans-muurola-4(15),5-diene (7.60%; 5.99 μg/g); two phenylpropanoids, benzyl alcohol (8.30%; 6.71 μg/g), and phenylacetaldehyde (7.74%; 6.26 μg/g); and the green-leaf alcohol cis-3-hexen-1-ol (9.69%; 7.84 μg/g). The ecological significance of the presence of such compounds is discussed.
Influence of the Mediterranean Diet on 25-Hydroxyvitamin D Levels in Adults
Authors: Barrea Luigi , Muscogiuri Giovanna , Laudisio Daniela , Pugliese Gabriella , de Alteriis Giulia , Colao Annamaria , Savastano Silvia
Published: May 2020

The Mediterranean diet (MD) is a dietary pattern effective in terms of prevention of obesity-related diseases, and represents the gold standard in preventive medicine, due to the synergistic action of many nutrients with antioxidant and anti-inflammatory properties. In addition, excess body weight significantly increases the risk of hypovitaminosis D, a well-recognized common feature of individuals with obesity. It is well-known that there is a clear gender difference in the adherence to the MD. The aim of this study was to investigate the association between adherence to the MD and 25-hydroxyvitamin D (25OHD) levels in adults, according to gender. Study population consisted of 617 participants; 296 were males and 321 were females, matched by age and body mass index (BMI). A validated 14-item questionnaire PREDIMED (Prevención con dieta Mediterránea) was used for the assessment of adherence to the MD. The 25OHD levels were determined by a direct competitive chemiluminescence immunoassay. Females have a higher PREDIMED score than males (7.4 ± 2.8 vs. 6.7 ± 3.1 score, p = 0.001), and according to PREDIMED categories, a greater percentage of males had low adherence to the MD compared to their female counterparts (40.2% vs. 37.1%; χ2 = 8.94, p = 0.003). The 25OHD levels were higher in males than in females (18.3 ± 7.3 vs. 16.8 ± 7.8 ng/mL, p = 0.01), and a higher percentage of males had sufficient 25OHD levels (>30 ng/mL) than their female counterparts (10.5% vs. 3.4%, χ2 = 10.96, p < 0.001). Stratifying the sample population according to 25OHD categories, BMI decreased and PREDIMED score increased significantly along with the increased 25OHD levels, in both males and females, respectively (p < 0.001). Looking at the bivariate correlations, PREDIMED score was positively correlated with 25OHD levels after adjusting for age and BMI, in both males (r = 0.21, p < 0.001) and females (r = 0.30, p < 0.001). At the bivariate proportional odds ratio (OR) model, 25OHD levels presented the highest OR values in the category low adherence vs. high adherence to the MD, in both genders (OR 1.21 and OR 1.31, in males and females, respectively). Receiver operator characteristic (ROC) analysis was performed to determine the cut-off values of PREDIMED scores predictive of 25OHD levels: PREDIMED score >5 in males (p < 0.001) and >7 in females (p < 0.001) could serve as thresholds for 25OHD levels above the median. The results of our study highlighted a novel positive association between adherence to the MD and 25OHD levels in both genders. Although 25OHD levels were higher in males than females, 69.7% were deficient. To the best of our knowledge, this is the first study to show that high adherence to the MD is associated with low BMI and high 25OHD levels in both genders, probably through the anti-inflammatory and anti-oxidant effects that are synergistically exerted by either MD or vitamin D on body weight.
Naturally Occurring PCSK9 Inhibitors
Authors: Adorni Maria Pia , Zimetti Francesca , Lupo Maria Giovanna , Ruscica Massimiliano , Ferri Nicola
Published: May 2020

Genetic, epidemiological and pharmacological data have led to the conclusion that antagonizing or inhibiting Proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces cardiovascular events. This clinical outcome is mainly related to the pivotal role of PCSK9 in controlling low-density lipoprotein (LDL) cholesterol levels. The absence of oral and affordable anti-PCSK9 medications has limited the beneficial effects of this new therapeutic option. A possible breakthrough in this field may come from the discovery of new naturally occurring PCSK9 inhibitors as a starting point for the development of oral, small molecules, to be used in combination with statins in order to increase the percentage of patients reaching their LDL-cholesterol target levels. In the present review, we have summarized the current knowledge on natural compounds or extracts that have shown an inhibitory effect on PCSK9, either in experimental or clinical settings. When available, the pharmacodynamic and pharmacokinetic profiles of the listed compounds are described.
Protein Distribution and Muscle-Related Outcomes: Does the Evidence Support the Concept?
Authors: Hudson Joshua , Bergia Robert , Campbell Wayne
Published: May 2020

There is a shift in thinking about dietary protein requirements from daily requirements to individual meal requirements. Per meal, stimulation of muscle protein synthesis has a saturable dose relationship with the quantity of dietary protein consumed. Protein intake above the saturable dose does not further contribute to the synthetic response; the “excess” amino acids are predominantly oxidized. Given that daily dietary protein intake is finite, finding protein distribution patterns that both reduce amino acid oxidation and maximize their contribution towards protein synthesis (in theory improving net balance) could be “optimal” and is of practical scientific interest to promote beneficial changes in skeletal muscle-related outcomes. This article reviews both observational and randomized controlled trial research on the protein distribution concept. The current evidence on the efficacy of consuming an “optimal” protein distribution to favorably influence skeletal muscle-related changes is limited and inconsistent. The effect of protein distribution cannot be sufficiently disentangled from the effect of protein quantity. Consuming a more balanced protein distribution may be a practical way for adults with marginal or inadequate protein intakes (<0.80 g·kg−1·d−1) to achieve a moderately higher total protein intake. However, for adults already consuming 0.8–1.3 g·kg−1·d−1, the preponderance of evidence supports that consuming at least one meal that contains sufficient protein quantity to maximally stimulate muscle protein synthesis, independent of daily distribution, is helpful to promote skeletal muscle health.
Effect of Cod Residual Protein Supplementation on Markers of Glucose Regulation in Lean Adults: A Randomized Double-Blind Study
Authors: Vildmyren Iselin , Halstensen Alfred , McCann Adrian , Midttun Øivind , Ueland Per Magne , Oterhals Åge , Gudbrandsen Oddrun Anita
Published: May 2020

Large quantities of protein-rich cod residuals, which are currently discarded, could be utilized for human consumption. Although fish fillet intake is related to beneficial health effects, little is known about the potential health effects of consuming cod residual protein powder. Fifty lean adults were randomized to consume capsules with 8.1 g/day of cod residual protein (Cod-RP) or placebo capsules (Control group) for eight weeks, in this randomized, double-blind study. The intervention was completed by 40 participants. Fasting glucose and insulin concentrations were unaffected by Cod-RP supplementation, whereas plasma concentrations of α-hydroxybutyrate, β-hydroxybutyrate and acetoacetate all were decreased compared with the Control group. Trimethylamine N-oxide concentration in plasma and urine were increased in the Cod-RP group compared with the Control group. To conclude, the reduction in these potential early markers of impaired glucose metabolism following Cod-RP supplementation may indicate beneficial glucoregulatory effects of cod residual proteins. Trimethylamine N-oxide appears to be an appropriate biomarker of cod residual protein intake in lean adults.
Changed Amino Acids in NAFLD and Liver Fibrosis: A Large Cross-Sectional Study without Influence of Insulin Resistance
Authors: Hasegawa Takuma , Iino Chikara , Endo Tetsu , Mikami Kenichiro , Kimura Masayo , Sawada Naoya , Nakaji Shigeyuki , Fukuda Shinsaku
Published: May 2020

Altered amino acid levels have been found in nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). However, it is not clear whether this alteration is due to altered hepatic metabolism or insulin resistance. The aim of this study was to clarify the association among amino acid levels, fatty liver, and liver fibrosis while eliminating the influence of insulin resistance. NAFLD and liver fibrosis were diagnosed using transient elastography and subjects were divided into three groups: normal, NAFLD, and liver fibrosis. To exclude the influence of insulin resistance, the subjects were matched using the homeostasis model assessment of insulin resistance (HOMA-IR). The amino acid serum levels were compared among the groups. Of 731 enrolled subjects, 251 and 33 were diagnosed with NAFLD and liver fibrosis. Although significant differences were observed among the groups in the serum levels of most amino acids, all but those of glutamate and glycine disappeared after matching for HOMA-IR. The multivariate logistic regression revealed that glutamate, glycine, and HOMA-IR were independent risk factors for liver fibrosis. The altered serum levels of most amino acids were associated with insulin resistance, while the increase in glutamate and the decrease in glycine levels were strongly associated not only with insulin resistance, but also with altered liver metabolism in patients with liver fibrosis.
Independent and Interactive Influences of Environmental UVR, Vitamin D Levels, and Folate Variant MTHFD1-rs2236225 on Homocysteine Levels
Authors: Jones Patrice , Lucock Mark , Martin Charlotte , Thota Rohith , Garg Manohar , Yates Zoe , Scarlett Christopher J. , Veysey Martin , Beckett Emma
Published: May 2020

Elevated homocysteine (Hcy) levels are a risk factor for vascular diseases. Recently, increases in ultraviolet radiation (UVR) have been linked to decreased Hcy levels. This relationship may be mediated by the status of UVR-responsive vitamins, vitamin D and folate, and/or genetic variants influencing their levels; however, this has yet to be examined. Therefore, the independent and interactive influences of environmental UVR, vitamin D and folate levels and related genetic variants on Hcy levels were examined in an elderly Australian cohort (n = 619). Red blood cell folate, 25-hydroxyvitamin D (25(OH)D), and plasma Hcy levels were determined, and genotyping for 21 folate and vitamin D-related variants was performed. Erythemal dose rate accumulated over six-weeks (6W-EDR) and four-months (4M-EDR) prior to clinics were calculated as a measure of environmental UVR. Multivariate analyses found interactions between 6W-EDR and 25(OH)D levels (pinteraction = 0.002), and 4M-EDR and MTHFD1-rs2236225 (pinteraction = 0.006) in predicting Hcy levels. The association between 6W-EDR and Hcy levels was found only in subjects within lower 25(OH)D quartiles (<33.26 ng/mL), with the association between 4M-EDR and Hcy occurring only in subjects carrying the MTHFD1-rs2236225 variant. 4M-EDR, 6W-EDR, and MTHFD1-rs2236225 were also independent predictors of Hcy. Findings highlight nutrient–environment and gene–environment interactions that could influence the risk of Hcy-related outcomes.
Sesamol Increases Ucp1 Expression in White Adipose Tissues and Stimulates Energy Expenditure in High-Fat Diet-Fed Obese Mice
Authors: Lee Dong Ho , Chang Seo-Hyuk , Yang Dong Kwon , Song No-Joon , Yun Ui Jeong , Park Kye Won
Published: May 2020

Sesamol found in sesame oil has been shown to ameliorate obesity by regulating lipid metabolism. However, its effects on energy expenditure and the underlying molecular mechanism have not been clearly elucidated. In this study, we show that sesamol increased the uncoupling protein 1 (Ucp1) expression in adipocytes. The administration of sesamol in high-fat diet (HFD)-fed mice prevented weight gain and improved metabolic derangements. The three-week sesamol treatment of HFD-fed mice, when the body weights were not different between the sesamol and control groups, increased energy expenditure, suggesting that an induced energy expenditure is a primary contributing factor for sesamol’s anti-obese effects. Consistently, sesamol induced the expression of energy-dissipating thermogenic genes, including Ucp1, in white adipose tissues. The microarray analysis showed that sesamol dramatically increased the Nrf2 target genes such as Hmox1 and Atf3 in adipocytes. Moreover, 76% (60/79 genes) of the sesamol-induced genes were also regulated by tert-butylhydroquinone (tBHQ), a known Nrf2 activator. We further verified that sesamol directly activated the Nrf2-mediated transcription. In addition, the Hmox1 and Ucp1 induction by sesamol was compromised in Nrf2-deleted cells, indicating the necessity of Nrf2 in the sesamol-mediated Ucp1 induction. Together, these findings demonstrate the effects of sesamol in inducing Ucp1 and in increasing energy expenditure, further highlighting the use of the Nrf2 activation in stimulating thermogenic adipocytes and in increasing energy expenditure in obesity and its related metabolic diseases.
Evaluating Nutrient-Based Indices against Food- and Diet-Based Indices to Assess the Health Potential of Foods: How Does the Australian Health Star Rating System Perform after Five Years?
Authors: Dickie Sarah , Woods Julie L. , Baker Phillip , Elizabeth Leonie , Lawrence Mark A.
Published: May 2020

Nutrient-based indices are commonly used to assess the health potential of individual foods for nutrition policy actions. This study aimed to evaluate the nutrient profile-informed Australian Health Star Rating (HSR), against NOVA and an index informed by the Australian Dietary Guidelines (ADGs), to determine the extent of alignment. All products displaying an HSR label in the Australian marketplace between June 2014 and June 2019 were extracted from the Mintel Global New Product Database, and classified into one of four NOVA categories, and either as an ADG five food group (FFG) food or discretionary food. Of 4451 products analysed, 76.5% were ultra-processed (UP) and 43% were discretionary. The median HSR of non-UP foods (4) was significantly higher than UP foods (3.5) (p < 0.01), and the median HSR of FFG foods (4) was significantly higher than discretionary foods (2.5) (p < 0.01). However, 73% of UP foods, and 52.8% of discretionary foods displayed an HSR ≥ 2.5. Results indicate the currently implemented HSR system is inadvertently providing a ‘health halo’ for almost ¾ of UP foods and ½ of discretionary foods displaying an HSR. Future research should investigate whether the HSR scheme can be reformed to avoid misalignment with food-and diet-based indices.
Retina-Targeted Delivery of 17β-Estradiol by the Topically Applied DHED Prodrug
Authors: Prokai-Tatrai Katalin , Nguyen Vien , De La Cruz Daniel L. , Guerra Rebecca , Zaman Khadiza , Rahlouni Fatima , Prokai Laszlo
Published: May 2020

The purpose of this study was to explore retina-targeted delivery of 17β-estradiol (E2), a powerful neuroprotectant, by its bioprecursor prodrug 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) administered as eye drops in animal models. Compared to the parent hormone, DHED displayed increased transcorneal flux ex vivo both with and without the presence of 2-hydroxypropyl-β-cyclodextrin used as a penetration-enhancing excipient in rat, rabbit, and pig. In vitro, the prodrug also showed facile bioactivation to E2 in the retina but not in the cornea. After topical administration to rats and rabbits, peak DHED-derived E2 concentrations reached 13 ± 5 ng/g and 18 ± 7 ng/g in the retina of female rats and rabbits, respectively. However, the prodrug remained inert in the rest of the body and, therefore, did not cause increase in circulating hormone concentration, as well as wet uterine and anterior pituitary weights as typical markers of E2′s endocrine impact. Altogether, our studies presented here have demonstrated the premise of topical retina-selective estrogen therapy by the DHED prodrug approach for the first time and provide compelling support for further investigation into the full potential of DHED for an efficacious and safe ocular neurotherapy.
Highly Elastic and Water Stable Zein Microfibers as a Potential Drug Delivery System for Wound Healing
Authors: Akhmetova Alma , Lanno Georg-Marten , Kogermann Karin , Malmsten Martin , Rades Thomas , Heinz Andrea
Published: May 2020

The development of biomaterials for wound healing applications requires providing a number of properties, such as antimicrobial action, facilitation of cell proliferation, biocompatibility and biodegradability. The aim of the present study was to investigate morphological and mechanical properties of zein-based microfibers, ultimately aimed at creating an environment suitable for wound healing. This was achieved through co-axial electrospinning of core–shell microfibers, with zein protein in the core and polyethylene oxide (PEO) in the shell. Small amounts of PEO or stearic acid were additionally incorporated into the fiber core to modify the morphology and mechanical properties of zein fibers. The presence of PEO in the core was found to be essential for the formation of tubular fibers, whereas PEO in the shell enhanced the stability of the microfibers in water and ensured high elasticity of the microfiber mats. Tetracycline hydrochloride was present in an amorphous form within the fibers, and displayed a burst release as a result of pore-formation in the fibers. The developed systems exhibited antimicrobial activity against Staphylococcus aureus and Escherichia coli, and showed no cytotoxic effect on fibroblasts. Biocompatibility, antimicrobial activity and favorable morphological and mechanical properties make the developed zein-based microfibers a potential biomaterial for wound healing purposes.
Lignin as a UV Light Blocker—A Review
Authors: Sadeghifar Hasan , Ragauskas Arthur
Published: May 2020

Lignin is the by-product of pulp and paper industries and bio-refining operations. It is available as the leading natural phenolic biopolymer in the market. It has chromophore functional groups and can absorb a broad spectrum of UV light in range of 250–400 nm. Using lignin as a natural ingredient in sunscreen cream, transparent film, paints, varnishes and microorganism protection has been actively investigated. Both in non-modified and modified forms, lignin provides enhancing UV protection of commercial products with less than a 10% blend with other material. In mixtures with other synthetic UV blockers, lignin indicated synergic effects and increased final UV blocking potential in compare with using only synthetic UV blocker or lignin. However, using lignin as a UV blocker is also challenging due to its complex structure, polydispersity in molecular weight, brownish color and some impurities that require more research in order to make it an ideal bio-based UV blocker.
Composite Polymeric Cryogel Cartridges for Selective Removal of Cadmium Ions from Aqueous Solutions
Authors: Huseynli Sabina , Bakhshpour Monireh , Qureshi Tahira , Andac Muge , Denizli Adil
Published: May 2020

In this study, composite polymeric cryogel cartridges were achieved by using Cd(II) imprinted poly(hydroxyethyl methacrylate N-methacryloly-(L)-cysteine methylester) beads and poly(hydroxyethyl methacrylate) cryogel cartridges with two different mole ratios of functional monomer. The N-methacryloly-(L)-cysteinemethylester was used as a functional monomer and Cd(II) 1:1 and 2:1, which were then notated as MIP1 and MIP2, respectively. Various characterization methods have confirmed the structural transformation on the MIP1 and MIP2 composite cryogel cartridges by scanning electron microscopy, Fourier-transform infrared spectroscopy-Attenuated Total Reflectance, and swelling tests. The maximum amount of Cd(II) adsorption with composite cryogel cartridges was determined by altering the Cd(II) initial concentration, temperature, and pH values. The maximum adsorption capacity of MIP1 and MIP2 composite cryogel cartridges obtained was 76.35 and 98.8 µmol/g of composite cryogels, respectively. The adsorption studies revealed that the MIP2 possessed a good adsorption performance for Cd(II). The obtained composite cryogel cartridges have a selective, reusable, and cost-friendly potential for the removal of Cd(II) from aqueous solutions, and are used many times without decreasing their adsorption capacities significantly. The Cd(II) removal rate of the MIP1 and MIP2 composite cryogel cartridges from synthetic wastewater samples was determined as 98.8%. The obtained cryogel cartridges’ adsorption material exhibited a good directional removal performance for Cd(II) from wastewater samples.
Beyond Amplitudes: Multi-Trace Coherence Analysis for Ground-Penetrating Radar Data Imaging
Authors: Trinks Immo , Hinterleitner Alois
Published: May 2020

Under suitable conditions, ground-penetrating radar (GPR) measurements harbour great potential for the non-invasive mapping and three-dimensional investigation of buried archaeological remains. Current GPR data visualisations almost exclusively focus on the imaging of GPR reflection amplitudes. Ideally, the resulting amplitude maps show subsurface structures of archaeological interest in plan view. However, there exist situations in which, despite the presence of buried archaeological remains, hardly any corresponding anomalies can be observed in the GPR time- or depth-slice amplitude images. Following the promising examples set by seismic attribute analysis in the field of exploration seismology, it should be possible to exploit other attributes than merely amplitude values for the enhanced imaging of subsurface structures expressed in GPR data. Coherence is the seismic attribute that is a measure for the discontinuity between adjacent traces in post-stack seismic data volumes. Seismic coherence analysis is directly transferable to common high-resolution 3D GPR data sets. We demonstrate, how under the right circumstances, trace discontinuity analysis can substantially enhance the imaging of structural information contained in GPR data. In certain cases, considerably improved data visualisations are achievable, facilitating subsequent data interpretation. We present GPR trace coherence imaging examples taken from extensive, high-resolution archaeological prospection GPR data sets.
Remote Sensing and Multi-Criteria Evaluation for Malaria Risk Mapping to Support Indoor Residual Spraying Prioritization in the Central Highlands of Madagascar
Authors: Rakotoarison Hobiniaina Anthonio , Rasamimalala Mampionona , Rakotondramanga Jean Marius , Ramiranirina Brune , Franchard Thierry , Kapesa Laurent , Razafindrakoto Jocelyn , Guis Hélène , Tantely Luciano Michaël , Girod Romain , Rakotoniaina Solofoarisoa , Baril Laurence , Piola Patrice , Rakotomanana Fanjasoa
Published: May 2020

The National Malaria Control Program (NMCP) in Madagascar classifies Malagasy districts into two malaria situations: districts in the pre-elimination phase and districts in the control phase. Indoor residual spraying (IRS) is identified as the main intervention means to control malaria in the Central Highlands. However, it involves an important logistical mobilization and thus necessitates prioritization of interventions according to the magnitude of malaria risks. Our objectives were to map the malaria transmission risk and to develop a tool to support the Malagasy Ministry of Public Health (MoH) for selective IRS implementation. For the 2014–2016 period, different sources of remotely sensed data were used to update land cover information and substitute in situ climatic data. Spatial modeling was performed based on multi-criteria evaluation (MCE) to assess malaria risk. Models were mainly based on environment and climate. Three annual malaria risk maps were obtained for 2014, 2015, and 2016. Annual parasite incidence data were used to validate the results. In 2016, the validation of the model using a receiver operating characteristic (ROC) curve showed an accuracy of 0.736; 95% CI [0.669–0.803]. A free plugin for QGIS software was made available for NMCP decision makers to prioritize areas for IRS. An annual update of the model provides the basic information for decision making before each IRS campaign. In Madagascar and beyond, the availability of the free plugin for open-source software facilitates the transfer to the MoH and allows further application to other problems and contexts.
Monitoring Water Quality of Valle de Bravo Reservoir, Mexico, Using Entire Lifespan of MERIS Data and Machine Learning Approaches
Authors: Arias-Rodriguez Leonardo F. , Duan Zheng , Sepúlveda Rodrigo , Martinez-Martinez Sergio I. , Disse Markus
Published: May 2020

Remote-sensing-based machine learning approaches for water quality parameters estimation, Secchi Disk Depth (SDD) and Turbidity, were developed for the Valle de Bravo reservoir in central Mexico. This waterbody is a multipurpose reservoir, which provides drinking water to the metropolitan area of Mexico City. To reveal the water quality status of inland waters in the last decade, evaluation of MERIS imagery is a substantial approach. This study incorporated in-situ collected measurements across the reservoir and remote sensing reflectance data from the Medium Resolution Imaging Spectrometer (MERIS). Machine learning approaches with varying complexities were tested, and the optimal model for SDD and Turbidity was determined. Cross-validation demonstrated that the satellite-based estimates are consistent with the in-situ measurements for both SDD and Turbidity, with R2 values of 0.81 to 0.86 and RMSE of 0.15 m and 0.95 nephelometric turbidity units (NTU). The best model was applied to time series of MERIS images to analyze the spatial and temporal variations of the reservoir’s water quality from 2002 to 2012. Derived analysis revealed yearly patterns caused by dry and rainy seasons and several disruptions were identified. The reservoir varied from trophic to intermittent hypertrophic status, while SDD ranged from 0–1.93 m and Turbidity up to 23.70 NTU. Results suggest the effects of drought events in the years 2006 and 2009 on water quality were correlated with water quality detriment. The water quality displayed slow recovery through 2011–2012. This study demonstrates the usefulness of satellite observations for supporting inland water quality monitoring and water management in this region.
Lossy Compression of Multispectral Satellite Images with Application to Crop Thematic Mapping: A HEVC Comparative Study
Authors: Radosavljević Miloš , Brkljač Branko , Lugonja Predrag , Crnojević Vladimir , Trpovski Željen , Xiong Zixiang , Vukobratović Dejan
Published: May 2020

Remote sensing applications have gained in popularity in recent years, which has resulted in vast amounts of data being produced on a daily basis. Managing and delivering large sets of data becomes extremely difficult and resource demanding for the data vendors, but even more for individual users and third party stakeholders. Hence, research in the field of efficient remote sensing data handling and manipulation has become a very active research topic (from both storage and communication perspectives). Driven by the rapid growth in the volume of optical satellite measurements, in this work we explore the lossy compression technique for multispectral satellite images. We give a comprehensive analysis of the High Efficiency Video Coding (HEVC) still-image intra coding part applied to the multispectral image data. Thereafter, we analyze the impact of the distortions introduced by the HEVC’s intra compression in the general case, as well as in the specific context of crop classification application. Results show that HEVC’s intra coding achieves better trade-off between compression gain and image quality, as compared to standard JPEG 2000 solution. On the other hand, this also reflects in the better performance of the designed pixel-based classifier in the analyzed crop classification task. We show that HEVC can obtain up to 150:1 compression ratio, when observing compression in the context of specific application, without significantly losing on classification performance compared to classifier trained and applied on raw data. In comparison, in order to maintain the same performance, JPEG 2000 allows compression ratio up to 70:1.
Inter-Comparisons of Daily Sea Surface Temperatures and In-Situ Temperatures in the Coastal Regions
Authors: Woo Hye-Jin , Park Kyung-Ae
Published: May 2020

In this study, seven, global, blended, sea surface temperature (SST) analyses, including Operational SST and Sea Ice Analysis (OSTIA), Canadian Meteorological Centre (CMC) analysis, Optimum Interpolation SST (OISST), Remote Sensing System (REMSS) analysis, Multi-scale Ultra-high Resolution SST (MURSST), Merged Satellite and In situ Data Global Daily SST (MGDSST), and Geo-Polar Blended SST (Blended SST) were conducted. In-situ temperature measurements were used for the years 2014–2018, from 35 narrowly-spaced buoys distributed along the Korean Peninsula coast, to investigate how well the SST analyses represent the temperatures at the coastal regions. Contrary to the overall accuracy of the SSTs in the global ocean and offshore regions, the root-mean-square errors for the analyses were relatively large over 1.27 K. Specifically, all SST analyses resulted in warm biases over 0.31 K, which became quite distinctive in the western and the southwestern coastal regions. Investigation of the errors identified relationships with the coastal zones of vigorous tidal mixing, shallow bathymetry, and absence of microwave measurements. Overall, temporal wavelet coherency between in-situ measurements and SST products revealed high coherency of greater than 0.8 in periods longer than 180 days, however, low coherency (<0.5) in the period shorter than 10 days was observed. Inter-comparisons between the SST analyses illustrated clear spatial differences in the correlations at both the coastal regions, along the southwestern coast of the Korean Peninsula and in the frontal regions, and in the marginal seas of the Northwest Pacific. Overall, the results emphasized on the importance of using real-time in-situ measurements as much as possible, to overcome the increasing SST errors in coastal regions.
Estimation of Canopy Gap Fraction from Terrestrial Laser Scanner Using an Angular Grid to Take Advantage of the Full Data Spatial Resolution
Authors: Gajardo John , Riaño David , García Mariano , Salas Javier , Martín M. Pilar
Published: May 2020

This paper develops an algorithm to estimate vegetation canopy gap fraction (GF), taking advantage of the full Terrestrial Laser Scanner (TLS) resolution. After calculating the TLS angular resolution, the algorithm identifies the missing laser hits (gaps) within an angular grid in the azimuthal and zenithal directions. The algorithm was first tested on angular data simulations with random (R), cluster (C) and random and cluster together (RC) gap pattern distributions. Noise introduced in the simulations as a percentage of the resolution accounted for the effect of TLS angular uncertainty. The algorithm performs accurately if angular noise is <6% of the angular resolution. To assess the impact of the change in projection, this study compared these GF estimates from angular grid simulations to their transformation into simulated hemispherical images (SHI). SHI with C patterns perform accurately, but R and RC patterns underestimate GF, especially for GF values below 0.6. The SHI performance to estimate GF was always far below the algorithm developed here with the angular grid simulations. When applied to actual TLS data acquired over individual Quercus ilex L. trees, the algorithm rendered a GF between 0.26 and 0.40. TLS had an angular noise <6%. Converting the angular grid into simulated HI (TLS-SHI) provided a better agreement with actual HI acquired in the same location as the TLS data, since they are in the same projection. The TLS-SHI underestimated GF by an average of 4% compared to HI. HI and TLS-SHI presented 14% and 17% lower values than the GF calculated from the angular grids, respectively. Nevertheless, the results from the simulations indicate that the algorithm based on the angular grid should be closer to the actual GF of the tree canopy.
Sentinel-1-Imagery-Based High-Resolution Water Cover Detection on Wetlands, Aided by Google Earth Engine
Authors: Gulácsi András , Kovács Ferenc
Published: May 2020

Saline wetlands experience large temporal fluctuations in water supply during the year and are recharged only or mainly through precipitation, meaning they are vulnerable to climate-change-induced aridification. Most passive satellite sensors are unsuitable for continuous wetland monitoring due to cloud cover and their relatively low temporal resolution. However, active satellite sensors such as the C-band synthetic aperture radar of Sentinel-1 satellites offer free, cloud-independent data. We examined surface water cover changes from October 2014 to November 2018 in the strictly protected area (13,000 ha) of the Upper-Kiskunság Alkaline Lakes region in the Danube–Tisza Interfluve in Hungary, with the aim of helping with nature protection planning. Changes and sensitivity can be defined based on the knowledge of variability. We developed a method for water cover detection based on automatic classification, applying the so-called WEKA K-Means clustering algorithm. For satellite data processing and analysis, we used the Google Earth Engine cloud processing platform. In terms of validation, we compared our results with the multispectral Modified Normalized Difference Water Index (MNDWI) derived from Landsat 8 and Sentinel-2 top-of-atmosphere reflectance images using a threshold-based binary classifier (receiver operator characteristics) for the MNDWI data. Using two completely distinct methods operating in distinct wavelength ranges, we obtained adequately matching results, with Spearman’s correlation coefficients (ρ) ranging from 0.54 to 0.80.