bluuebunny/crossref_metadata_2025 huggingface dataset:
Framework for the Promotion of Accountability in the Social Economy: The Specific Case of Private Social Solidarity Institutions
Authors: Ferreira Augusta , Santos Carlos , Inácio Helena , Costa Alberto J. , Bandeira Ana Maria , Tomé Brízida , Joaquim Carla , Góis Cristina , Curi Denise , Meira Deolinda , Azevedo Graça , Jesus Mafalda , Teixeira Maria Goreti , Monteiro Patrícia , Duarte Rúben , Marques Rui Pedro
Published: December 2021

Given the extreme importance of improving the accountability of Private Social Solidarity Institutions (IPSS), both for reasons of legal compliance (hard law) and for reasons of improving legitimacy and notoriety among their stakeholders (soft law), this paper aims to present a framework designed under a more comprehensive research project, for the assessment of IPSS accountability and, consequently, its improvement. This study also present results of the indicators conceived, identifying the main trends of the framework dimensions and sub-dimensions from a pilot test for the years 2018, 2019 and 2020 in Portugal. Given the results, we believe that the framework designed answers the research question: How to promote accountability (social, financial and economic) in the social economy sector, in particular: the case of the IPSS?, however, as this is an exploratory article, it incorporates the limitation that this is a pilot test with only 7 entities.
Bridge Digital Twining Using an Output-Only Bayesian Model Updating Method and Recorded Seismic Measurements
Authors: Ghahari Farid , Malekghaini Niloofar , Ebrahimian Hamed , Taciroglu Ertugrul
Published: December 2021

Rapid post-earthquake damage diagnosis of bridges can guide decision-making for emergency response management and recovery. This can be facilitated using digital technologies to remove the barriers of manual post-event inspections. Prior mechanics-based Finite Element (FE) models can be used for post-event response simulation using the measured ground motions at nearby stations; however, the damage assessment outcomes would suffer from uncertainties in structural and soil material properties, input excitations, etc. For instrumented bridges, these uncertainties can be reduced by integrating sensory data with prior models through a model updating approach. This study presents a sequential Bayesian model updating technique, through which a linear/nonlinear FE model, including soil-structure interaction effects, and the foundation input motions are jointly identified from measured acceleration responses. The efficacy of the presented model updating technique is first examined through a numerical verification study. Then, seismic data recorded from the San Rogue Canyon Bridge in California are used for a real-world case study. Comparison between the free-field and the foundation input motions reveals valuable information regarding the soil-structure interaction effects at the bridge site. Moreover, the reasonable agreement between the recorded and estimated bridge responses shows the potentials of the presented model updating technique for real-world applications. The updated FE model is considered as the digital twin of the bridge and can be used to analyze the bridge and monitor the structural response at element, section, and fiber levels to diagnose the location and severity of any potential damage mechanism.
Axial Force Analysis of the Support Bracket of Pumped Storage Unit
Authors: Xu Buchao , Zhao Weiqiang , Lin Wenhua , Mao Zhongyu , Tao Ran , Wang Zhengwei
Published: December 2021

During operation, the support bracket is the main part to withstand the axial loads of the pumped storage unit. Moreover, the effects of axial loads including the hydraulic thrust of runner flow and the weight of runner body may cause the support bracket deformation and fatigue damage. For the safe and stable operation, the simulation of the axial force and the structural analysis of the support bracket of a pumped storage unit was carried out in this paper. The CFD simulation result has revealed the variation rule of the axial force in different operating conditions. Using ANSYS Mechanical, the static stresses and deformation of support bracket with axial loads were calculated. The results release the location and variations of maximum stress and maximum deformation caused by the axial loads. By comparing the predicted maximum axial force with the admission force calculated by the structural analysis, it is found that the axial force of the researched machine is within the safe range. This study provides the reference for the safety and stable operation of the pumped storage unit.
The Antecedents of Calling: A Career Construction Perspective
Authors: Ulfa Bella , Riasnugrahani Missiliana , Riantoputra Corina D
Published: December 2021

"Research Aims: This study aims to examine the moderating role of leader autonomy support (LAS) in the indirect relationship between cognitive flexibility and calling through job crafting. Design/methodology/approach: Data were collected through an online survey from employees who have been working at a private company for a minimum of one year. Using a convenience sampling method, data were collected from a total of 140 respondents. Data were analysed in SPSS using a moderated mediation model. Research Findings: The results showed that LAS moderated the indirect effect of cognitive flexibility on calling through job crafting. Theoretical Contribution/Originality: This study illustrates the complex relationship between cognitive flexibility, job crafting, and LAS as the antecedents of calling by drawing on career construction theory (CCT), while simultaneously emphasising the importance of situational factors (i.e., LAS) in finding a calling, especially for employees. Managerial Implication in the South East Asian context: Companies are expected to put more effort into understanding the role of individual and situational factors in their employees' journey toward finding a calling. Specifically, leaders' support for employees' job crafting should be strengthened to facilitate employees in discerning their work as a calling. Research limitations & implications: This study has limitations regarding the data collection, as it only uses a cross-sectional design. Additionally, this study only examines the antecedents of calling through employees' perception."
Unsaturated Flow Influences the Response of Leaky Aquifer to Earth Tides
Authors: Zhu Ai-Yu
Published: December 2021

Most studies about the tidal response of leaky aquifers have treated the layered groundwater system as a classical unconfined aquifer without unsaturated flow. However, a recent study has shown that the conventional hypothesis of free drainage of groundwater to the watertable may be defective and the unsaturated flow may strongly affect their tidal response. Hence, it is critical to examine if unsaturated flow may also affect the tidal response of a layered groundwater system. In this study, we apply two-dimensional multilayered numerical simulations to examine the tidal response of unsaturated flow in a leaky aquifer. The results show that unsaturated flow on the watertable may significantly affect the tidal response of deeply buried aquifers, and the thicker the unsaturated zone is, the greater influence on the groundwater response to earth tide would be. Besides, a dimensionless quality ω∗ is introduced to estimate the effect of the unsaturated flow. When ω∗>10−0.5, the effect of the unsaturated flow on the tidal response of the water level is evidently; otherwise, the effect can be neglected. We then apply the numerical model to interpret the tidal response of a well installed in Lijiang, Yunnan province, China. It perfectly explains that the phase shift and amplitude ratio, respectively, decrease and increase exponentially when the watertable is below the ground surface. This study emphasizes the necessity of considering unsaturated flow in the multilayered model to improve the accuracy of predicting the permeability of the leaky aquifer.
EFEKTIVITAS PROGRAM BANTUAN PEMERINTAH BAGI USAHA MIKRO DI KABUPATEN PONOROGO
Authors: Mustofa Nida Faizatul , Ratna Yunita
Published: December 2021

One of the government's efforts to overcome the COVID-19 pandemic which has affected several sectors, one of which is the economic sector, is by launching the Government Assistance for Micro Enterprises (BPUM) program. This BPUM aims to support and maintain the sustainability of micro-enterprises as well as a form of saving the national economy during the COVID-19 pandemic that threatens the national economy. This program was only issued during the 2019 covid pandemic, so it is still very new and there is still not much research on this program. The problem in this research is how the effectiveness of achieving the objectives, integration, and adaptation of the Government Assistance for Micro Enterprises (BPUM) program is. This research program uses a field method using a qualitative approach and uses a descriptive type of research. The results of the research are, firstly, the measure of achieving the goals has not been effective because the targets have not been fully accurate and the management of aid funds is still not in accordance with the objectives. Second, the integration measure has not been effective because there is no socialization from related parties to the prospective recipients of the BPUM program. And third, the adaptation measure has not been effective either because the implementing party did not conduct monitoring before or after receiving this assistance program.

Salah satu upaya pemerintah dalam mengatasi pendemi covid-19 yang mengakibatkan beberapa sektor terdampak, salah satunya sektor perekonomian yaitu dengan mencanangkan program Bantuan Pemerintah bagi Usaha Mikro (BPUM). BPUM ini bertujuan untuk mendukung dan menjaga keberlangsungan usaha mikro serta sebagai bentuk penyelamatan ekonomi Nasional pada masa pandemi covid-19 yang mengancam perekonomian Nasional. Program ini baru dikeluarkan pada saat pandemi covid tahun 2019, sehingga masih sangat baru dan masih belum banyak penelitan tentang program ini. Permasalahan dalam penelitian ini adalah bagaimana efektivitas pencapaian tujuan, integrasi, dan adaptasi program Bantuan Pemerintah bagi Usaha Mikro (BPUM). Program Penelitian ini menggunakan metode lapangan dengan menggunakan pendekatan kualitatif dan menggunakan jenis penelitian deskriptif. Hasil penelitian yaitu, pertama pada ukuran pencapaian tujuan belum efektif dikarenakan target sasaran belum sepenuhnya tepat serta pengelolaan dana bantuan yang masih belum sesuai dengan tujuan. Kedua, pada ukuran integrasi belum efektif karena tidak adanya sosialisasi dari pihak terkait terhadap calon penerima program BPUM. Dan ketiga, pada ukuran adaptasi juga belum efektif karena pihak pelaksana tidak melakukan pemantauan sebelum maupun sesudah menerima program bantuan ini.
The Effect of Relative Permeability Hysteresis on the Design of an Optimal Water-Alternating-Gas (WAG) Process
Authors: Kowsari M. , James L. A. , Haynes R. D.
Published: December 2021

Water-alternating gas (WAG) as a tertiary recovery method is applied to oil reservoirs at a later stage of reservoir life to more or less success depending on field and operation. Uncertainty in WAG optimization has been shown to be dependent on several factors including reservoir characterization, WAG timing, and its operation. In this paper, we comprehensively explore WAG optimization in the context of WAG operating parameters and hysteresis, the first paper to explore both simultaneously. WAG operating parameters have been analyzed and optimized at both the core and field scale with a general conclusion that the timing, miscibility, WAG ratio, cycle time, and number of cycles play a varying role in the WAG optimization. Reservoir characterization has considered well configuration, oil type, rock properties, and hysteresis in relative permeability. Due to the cyclic nature of WAG and the dependency of the relative permeability on the saturation history, the relative permeability hysteresis modeling plays a key role in WAG performance whereby different hysteresis models will predict different results, as shown in literature. In this paper, we consider the choice of the hysteresis model and WAG operating parameters on WAG optimization. First, a sensitivity analysis is performed to evaluate the effect of hysteresis models (no hysteresis, Carlson, and Killough) on a large number of WAG development scenarios sampled by the Latin hypercube sampling method. Next, optimizations were conducted to compare and analyze the optimum recovery factor and corresponding optimal WAG operating parameters for various combinations of hysteresis models. The results of the study indicate that excluding hysteresis modeling from simulations would likely lead to a higher predicted produced volume of the nonwetting phases, that is, oil and gas, and a lower predicted produced volume of the wetting phase, that is, water. Also, the optimal recovery factor as well as the optimal WAG operating parameters can be significantly affected by the choice of the hysteresis models.
Harbiye (Hatay) Şelaleler Bölgesindeki Şev Duraysızlıklarının Mühendislik Jeolojisi Açısından Değerlendirilmesi
Authors: DUYAN Mehmet , TÜRKMEN Sedat
Published: December 2021

Bu çalışmada, Hatay İli, Defne İlçesi Harbiye Mahallesi Şelaleler bölgesinde bulunan şevlerin duraylılığı değerlendirilmiş ve bölgenin heyelan riskinin azaltılması ile ilgili uygun çözümlerin ortaya konulması amaçlanmıştır. Çalışma kapsamında inceleme alanında sondajlar, presiyometre deneyleri ve inklinometre ölçümleri yapılmıştır. İnceleme alanında şev duraylılık problemlerinin bulunduğu bölgedeki litolojik birimler siltli kil ve kiltaşıdır. Her birime ait kayma direnci parametreleri belirlenmiş ve Slide 3D yazılımı ile üç boyutlu şev stabilite analizi yapılmıştır. Şev stabilite analizlerinde, direk kesme deneyi, geri analiz ve RocData ile olmak üzere üç farklı yöntem kullanılarak elde edilen kayma dayanım parametreleri ayrı ayrı göz önünde bulundurulmuş ve bu üç farklı durum için güvenlik katsayısı hesaplamaları yapılmıştır.

Güvenlik katsayısı hem statik durum hem de deprem durumu senaryoları için hesaplanmıştır. İlk senaryoda, direk kesme deneyinden elde edilen kiltaşına ait parametreler kullanılmıştır. İkinci senaryoda, RocData yazılımı ile elde edilen kiltaşına ait parametreler kullanılmıştır. Üçüncü senaryoda ise geri analiz ile elde edilen kiltaşına ait parametreler kullanılmıştır. Tüm senaryolar değerlendirilmiş ve geri analiz ile

elde edilen kiltaşına ait kayma parametrelerinin bulunduğu üçüncü senaryonun gerçeğe en yakın koşulları yansıttığı görülmüştür.
Addition of anaerobic ammonium oxidation bacteria to lower running cost during the membrane bioreactor process treating sewage
Authors: Sun Ronglin , Zhang Wenjie
Published: December 2021

Reducing energy consumption or running cost associated with the membrane bioreactor (MBR) process is a serious challenge that needs to be addressed in treating sewage. The addition of anaerobic ammonium oxidation bacteria (AnAOB) to a running MBR has the potential to lower the aeration rate, thus decreasing the running cost in treating sewage. The results obtained showed that owing to addition of AnAOB, TN and NH4+-N removal rates increased by 9.8% and 1.13%, respectively, while the aeration rate decreased by 50%. Additionally, high throughput sequencing and isotope experiments showed that both AnAOB and heterotrophic denitrification bacteria could survive simultaneously and play an important role in nitrogen removal, with AnAOB having a significantly greater contribution. It can be concluded that the addition of AnAOB reduced the running cost of MBR in treating sewage.
Sugar-Derived Amidines and Congeners: Structures, Glycosidase Inhibition
and Applications
Authors: Blériot Yves , Auberger Nicolas , Désiré Jérôme
Published: December 2021

Glycosidases, the enzymes responsible for the breakdown of glycoconjugates including di-, oligo- and polysaccharides are ubiquitous through all kingdoms of life. The extreme chemical stability of the glycosidic bond combined with the catalytic rates achieved by glycosidases makes them among the most proficient of all enzymes. Given their multitude of roles in vivo, inhibition of these enzymes is highly attractive with potential in the treatment of a vast array of pathologies ranging from lysosomal storage and diabetes to viral infections. Therefore great efforts have been invested in the last three decades to design and synthesize inhibitors of glycosidases leading to a number of drugs currently on the market. Amongst the vast array of structures that have been disclosed, sugars incorporating an amidine moiety have been the focus of many research groups around the world because of their glycosidase transition state-like structure. In this review we report and discuss the structure, the inhibition profile and the use of these molecules including related structural congeners as transition state analogs.
Identification of Potential Pleiotropic Genes for Immune and Skeletal Diseases Using Multivariate MetaCCA Analysis
Authors: He Pei , Cao Rong- Rong , Deng Fei- Yan , Lei Shu- Feng
Published: December 2021

Background:

Immune and skeletal systems physiologically and pathologically interact with each other. The immune and skeletal diseases may share potential pleiotropic genetics factors, but the shared specific genes are largely unknown

Objective:

This study aimed to investigate the overlapping genetic factors between multiple diseases (including rheumatoid arthritis (RA), psoriasis, osteoporosis, osteoarthritis, sarcopenia and fracture)

Methods:

The canonical correlation analysis (metaCCA) approach was used to identify the shared genes for six diseases by integrating genome-wide association study (GWAS)-derived summary statistics. Versatile Gene-based Association Study (VEGAS2) method was further applied to refine and validate the putative pleiotropic genes identified by metaCCA.

Results:

About 157 (p< 8.19E-6), 319 (p<3.90E-6) and 77 (p<9.72E-6) potential pleiotropic genes were identified shared by two immune disease, four skeletal diseases, and all of the six diseases, respectively. The top three significant putative pleiotropic genes shared by both immune and skeletal diseases, including HLA-B, TSBP1 and TSBP1-AS1 (p<E-300) were located in the major histocompatibility complex (MHC) region. Nineteen of 77 putative pleiotropic genes identified by metaCCA analysis were associated with at least one disease in the VEGAS2 analysis. Specifically, majority (18) of these 19 putative validated pleiotropic genes were associated with RA.

Conclusion:

The metaCCA method identified some pleiotropic genes shared by the immune and skeletal diseases. These findings help to improve our understanding of the shared genetic mechanisms and signaling pathways underlying immune and skeletal diseases.
An Overview of Databases and Bioinformatics Tools for Plant Antimicrobial
Peptides
Authors: Quintans Isadora Louise Alves da Costa Ribeiro , de Araújo João Victor Alcoforado , Rocha Lívia Noêmia Morais , de Andrade Annie Elisabeth Beltrão , do Rêgo Thaís Gaudencio , Deyholos Michael K.
Published: December 2021

:

Antimicrobial peptides (AMPs) are small, ribosomally synthesized proteins found in
nearly all forms of life. In plants, AMPs play a central role in plant defense due to their distinct
physicochemical properties. Due to their broad-spectrum antimicrobial activity and rapid killing action,
plant AMPs have become important candidates for the development of new drugs to control
plant and animal pathogens that are resistant to multiple drugs. Further research is required to explore
the potential uses of these natural compounds. Computational strategies have been increasingly
used to understand key aspects of antimicrobial peptides. These strategies will help to minimize
the time and cost of “wet-lab” experimentation. Researchers have developed various tools and
databases to provide updated information on AMPs. However, despite the increased availability of
antimicrobial peptide resources in biological databases, finding AMPs from plants can still be a difficult
task. The number of plant AMP sequences in current databases is still small and yet often redundant.
To facilitate further characterization of plant AMPs, we have summarized information on
the location, distribution, and annotations of plant AMPs available in the most relevant databases
for AMPs research. We also mapped and categorized the bioinformatics tools available in these
databases. We expect that this will allow researchers to advance in the discovery and development
of new plant AMPs with potent biological properties. We hope to provide insights to further expand
the application of AMPs in the fields of biotechnology, pharmacy, and agriculture.
Efficient High-throughput Techniques for the Analysis of Disease-
Resistant Plant Varieties and Detection of Food Adulteration
Authors: Salgotra Romesh Kumar , Bhat Javaid Akhter
Published: December 2021

Over the past two decades, the advances in the next generation sequencing (NGS) platforms
have led to the identification of numerous genes/QTLs at high-resolution for their potential
use in crop improvement. The genomic resources generated through these high-throughput sequencing
techniques have been efficiently used in screening of particular gene of interest particularly for
numerous types of plant stresses and quality traits. Subsequently, the identified-markers linked to a
particular trait have been used in marker-assisted backcross breeding (MABB) activities. Besides,
these markers are also being used to catalogue the food crops for detection of adulteration to improve
the quality of food. With the advancement of technologies, the genomic resources are originating
with new markers; however, to use these markers efficiently in crop breeding, high-throughput
techniques (HTT) such as multiplex PCR and capillary electrophoresis (CE) can be exploited.
Robustness, ease of operation, good reproducibility and low cost are the main advantages of multiplex
PCR and CE. The CE is capable of separating and characterizing proteins with simplicity,
speed and small sample requirements. Keeping in view the availability of vast data generated
through NGS techniques and development of numerous markers, there is a need to use these resources
efficiently in crop improvement programmes. In summary, this review describes the use of
molecular markers in the screening of resistance genes in breeding programmes and detection of
adulterations in food crops using high-throughput techniques.
Molecular Pathways, Targeted Therapies, and Proteomic Investigations of Colorectal Cancer
Authors: Yerlikaya Azmi , Zeren Sezgin
Published: December 2021

According to the GLOBOCAN 2020 data, colorectal cancer is the third most commonly diagnosed cancer and the second leading cause of cancer-related death. The risk factors for colorectal cancer include a diet abundant with fat, refined carbohydrates, animal protein, low fiber content, alcoholism, obesity, long-term cigarette smoking, low physical activity, and aging. Colorectal carcinomas are classified as adenocarcinoma, neuroendocrine, squamous cell, adenosquamous, spindle cell, and undifferentiated carcinomas. In addition, many variants of colorectal carcinomas have been recently distinguished based on histological, immunological, and molecular characteristics. Recently developed targeted molecules in conjunction with standard chemotherapeutics or immune checkpoint inhibitors provide promising treatment protocols for colorectal cancer. However, the benefit of targeted therapies is strictly dependent on the mutational status of signaling molecules (e.g., KRAS) or mismatch repair systems. Here it is aimed to provide a comprehensive view of colorectal cancer types, molecular pathways associated, recently developed targeted therapies, as well as proteomic investigations applied to colorectal cancer for the discovery of novel biomarkers and new targets for treatment protocols.
Elongated Internal Carotid Arteries in Patients with Severe Carotid Artery Stenosis
Authors: Tamada Tomoaki , Imaizumi Toshio , Komura Shoichi , Nomura Tatsufumi , Kanno Aya , Inamura Shigeru , Nonaka Tadashi
Published: December 2021

Objective:

To investigate the risk factors and asymptomatic cerebrovascular diseases associated with elongated internal carotid arteries (ICAs), and the relationship between ICA elongation and severe carotid artery (CA) stenosis

Methods:

We evaluated risk factors for stroke and magnetic resonance imaging (MRI) findings in patients with severe CA stenosis compared with people without neurological disorders who underwent brain screening (controls). On Magnetic resonance angiography (MRA) images we measured the longest distance, defined as the ICA distance, from the most distant anterior wall of the cervical ICA at the site of bending or kinking to the line between the origin of the external CA and the anterior protrusion of the ICA near the petrosal bone. We retrospectively compared various asymptomatic findings, including cerebral microbleeds, lacunar infarctions, and deep white matter hyperintensities (WMHs), between participants with an ICA distance ≥ 1.2 cm vs. < 1.2 cm. The prevalence of findings and stroke risk factors were compared using multivariate logistic regression models.

Results:

We evaluated 53 patients (70.0 ± 8.1 years old, nine female) with severe CA stenosis treated by CA stenting and 400 controls (63.0 ± 9.2 years old, 227 females). Multivariate analyses showed that ICA distance ≥ 1.2 cm was associated with age ≥ 65 years (odds ratio [OR] = 1.8, p < 0.01), severe deep WMHs (OR = 2.0, p = 0.02), and severe CA stenosis (OR = 0.17, p < 0.01).

Conclusion:

ICA elongation, measured by ICA distance, was positively associated with age and deep WMHs and negatively associated with severe CA stenosis.
Control of β-Site Amyloid Precursor Protein-Cleaving Enzyme-1 Expression
by Protein Kinase C-λ/ι and Nuclear Factor κ-B
Authors: Farese Robert V. , Sajan Mini P. , Leitges Michael , Park Colin , Diamond David M. , Wu Jin , Hansen Barbara C. , Duncan Mildred A. , Apostolatos Christopher A. , Apostolatos Andre H. , Kindy Mark
Published: December 2021

Βackground:

β-Amyloid precursor protein-cleaving enzyme-1 (BACE1) initiates the
production of Aβ-peptides that form Aβ-plaque in Alzheimer’s disease.

Methods:

Reportedly, acute insulin treatment in normal mice, and hyperinsulinemia in high-fat-fed
(HFF) obese/diabetic mice, increase BACE1 activity and levels of Aβ-peptides and phospho-
-thr-231-tau in the brain; moreover, these effects are blocked by PKC-λ/ι inhibitors. However, as
chemical inhibitors may affect unsuspected targets, we presently used knockout methodology to
further examine PKC-λ/ι requirements. We found that total-body heterozygous PKC-λ knockout reduced acute stimulatory effects of insulin and chronic effects of hyperinsulinemia in HFF/obese/diabetic mice, on brain PKC-λ activity and production of Aβ1-40/42 and phospho-thr-231-tau. This protection in HFF mice may reflect that hepatic PKC-λ haploinsufficiency prevents the development
of glucose intolerance and hyperinsulinemia.

Results:

On the other hand, heterozygous knockout of PKC-λ markedly reduced brain levels of
BACE1 protein and mRNA, and this may reflect diminished activation of nuclear factor kappa-B
(NFκB), which is activated by PKC-λ and increases BACE1 and proinflammatory cytokine transcription. Accordingly, whereas intravenous administration of aPKC inhibitor diminished aPKC activity and BACE1 levels by 50% in the brain and 90% in the liver, nasally-administered inhibitor
reduced aPKC activity and BACE1 mRNA and protein levels by 50-70% in the brain while sparing
the liver. Additionally, 24-hour insulin treatment in cultured human-derived neurons increased
NFκB activity and BACE1 levels, and these effects were blocked by various PKC-λ/ι inhibitors.

Conclusion:

PKC-λ/ι controls NFκB activity and BACE1 expression; PKC-λ/ι inhibitors may be
used nasally to target brain PKC-λ/ι or systemically to block both liver and brain PKC-λ/ι, to regulate NFκB-dependent BACE1 and proinflammatory cytokine expression.
Assessment of apolipoprotein E genotype for β-amyloid status prediction
Authors: Peña-Bautista Carmen , Álvarez-Sánchez Lourdes , García Lorena , Baquero Miguel , Cháfer-Pericás Consuelo
Published: December 2021

Background:

Apolipoprotein E (ApoE) is the major genetic risk factor for sporadic
Alzheimer's Disease (AD). Some studies showed a relationship between ApoE4 genotype and the
cerebrospinal fluid (CSF) biomarkers (β-amyloid42, p-Tau, t-Tau), as well as with cognitive status.
In this sense, it could be interesting to develop an approach to establish amyloid status in a minimally invasive way.

Methods:

The present study assessed the ApoE genotype in different participant groups (mild cognitive impairment due to AD (MCI-AD), mild/moderate dementia due to AD, MCI not due to AD
(MCI not AD), other neurological diseases, healthy participants) (n = 342).

Results:

As expected, the ApoE4 allele was more prevalent in AD patients, characterized by impairment in CSF β-amyloid42 levels (Aβ +), than in the other groups (Aβ -). In this sense, ApoE4-carrier subjects showed lower CSF levels for β-amyloid42 and higher CSF levels for t-Tau and p-Tau.
From this, a multivariate model to predict Aβ status was developed by means of partial least square
analysis (PLS) and predictive variables (ApoE genotype, cognitive score, sex, age). This model
showed suitable AUC-ROC 0.792 (95% CI, 0.744-0.840) and predictive negative value (81.6%).

Conclusion:

ApoE genotype could be useful in detecting CSF β-amyloid42 impairment associated
with early AD development.
Subcellular Proteomic Analysis Reveals Dysregulation in the Organization
of Human A549 Cells Infected with Influenza Virus H7N9
Authors: Song Zhigang , Zhang Lijun , Yin Lin , Liu Siyuan , Shi Huichun , Feng Yanling , Zhang Yujiao , Wu Dage
Published: December 2021

Background:

H7N9 influenza virus poses a high risk to human beings, and proteomic
evaluations of this virus may help better understand its pathogenic mechanisms in human systems.

Objective:

This study aimed at determining membrane proteins related to H7N9 infection.

Methods:

In this study, we infected primary human alveolar adenocarcinoma epithelial cells
(A549) with H7N9 (including wild and mutant strains) and then produced enriched cellular membrane
isolations, which were then evaluated by western blot. The proteins in these cell membrane
fractions were analyzed using the isobaric Tags for Relative and Absolute Quantitation (iTRAQ)
proteome technologies.

Results:

Differentially expressed proteins (n = 32) were identified following liquid chromatography-
tandem mass spectrometry, including 20 down-regulated proteins, such as CD44 antigen and
CD151 antigen, and 12 up-regulated proteins, such as tight junction protein ZO-1 and prostaglandin
reductase 1. Gene Ontology database searching revealed that 20 out of the 32 differentially
expressed proteins were localized to the plasma membrane. These proteins were primarily associated
with the cellular component organization (n = 20) and enriched in the reactome pathway of extracellular
matrix organization (n = 4).

Conclusion:

These findings indicate that H7N9 may dysregulate cellular organization via specific
alterations to the protein profile of the plasma membrane.
Anti-synthetase Syndrome Complicated by Pyogenic Myositis
Authors: Lizarazo David , Cifuentes Karen , Forero Paula Andrea , Páez Hernan
Published: December 2021

Background:

Anti-synthetase syndrome is a rare autoimmune disorder characterized by
autoantibodies against aminoacyl-tRNA-synthetases. Inflammatory myopathy and interstitial lung
disease could be present among other manifestations. Anti-Jo-1 is the most common antisynthetase
antibody and is the most likely to present with the classic triad (interstitial lung disease, myositis,
and arthritis), and includes more muscle and joint involvement than patients with other antisynthetase
antibodies.

Case report:

Here, we present a case of a 60-year-old female patient with a previous diagnosis of
myositis, secondary to the anti-synthetase syndrome, a complication of pyogenic myositis.

Conclusion:

The diagnosis of anti-synthetase syndrome is made by a multidisciplinary approach,
and occasionally, muscle and/or lung biopsy is needed. Imaging studies, especially magnetic resonance
imaging, based on findings such as muscle and fascial edema, and fatty tissue replacement,
allow an optimal approach.
Neutralizing Aminesin Boiler Steam and Humidified Indoor Air
Authors: Gomes Andrew , Tao Ye , Bhuiyan Abdul , Guan Don , Memarzadeh Farhad
Published: December 2021

Objective:

The health and comfort of the indoor population have been impacted by the humidity. While people are increasingly spending more time indoors, the presence of pollutants and lack of proper humidification in indoor air have significant risk factors that may lead to multiple health problems.

Methods:

By applying the right air purification and/or humidification system, the adverse effects of poor indoor air quality can be minimized. Direct steam addition is a common technique to humidify the indoor air of a building. Carbon dioxide or other acidic process contaminants may dissolve in steam or steam condensate that will consequently decrease the pH and make it corrosive for the steam distribution system. To avoid that, neutralizing amines are added to steam that keeps the pH neutral or slightly alkaline(pH 7.5-9.0). However, neutralizing amines have some toxic effects. OSHA, FDA, and NIOSH prescribe maximum concentration limits for them in indoor air. The Central Utility Plant (CUP) of National Institutes of Health (NIH) uses a 50:50 blend of cyclohexylamine and diethylaminoethanol as neutralizing agents for the steam.

Results:

The CUP at NIH presents the results of monitoring the concentration level of amines through mass balance, online monitoring at specified location of the steam distribution system and field measurement in humidified indoor air at buildings on campus.

Conclusion

Through theoretical calculation backed up by field measurement, the amine concentration of indoor air is determined to be well below the FDA regulated limits.
Agro-Waste Sourced Catalyst as an Eco-Friendly and Sustainable Approach
for Knoevenagel Condensation Reaction
Authors: Kamanna Kantharaju , Badiger Krishnappa B. , Khatavi Santosh Y. , Hiremath Prashant B.
Published: December 2021

Background:

The present work describes an eco-friendly and sustainable approach for
the Knoevenagel condensation of an aromatic aldehyde with ethyl cyanoacetate, and salicylaldehyde
with Meldrum acid for the synthesis of ethyl benzylidenecyanoacetate and 3-carboxy coumarin
(2-oxo-2H-1-benzopyran) derivatives, respectively. The reaction was performed under green
catalytic media-Water Extract of Watermelon Fruit Peel Ash (WEWFPA), which is an eco-friendly
protocol derived from the agro-waste feedstock. Various protocols have been reported for the synthesis
of Knoevenagel condensation reaction using a hazardous catalyst or/and solvents found toxic
to the environment, requiring longer reaction time, giving poor yield, and requiring purification of
the final product. The method at hand provides several added advantages like: being a completely
green method, economic, inexpensive catalyst, and the final product isolated is in pure form with
good yield.

Objective:

The objective of the study was to develop a green methodology for the synthesis of
ethyl benzylidenecyanoacetate and 3-carboxy coumarin derivatives.

Results:

The agro-waste based catalyst developed in the present study avoids the use of external inorganic/
organic bases and additives. Knoevenagel condensation of ethyl benzylidenecyanoacetate
and 3-carboxy coumarin derivatives is carried out under room temperature using microwave irradiation,
which is a solvent-free synthesis, requiring less time and giving better yield.

Methods:

We have demonstrated that WEWFPA can be employed as a green homogenous agrowaste
for the synthesis of ethyl benzylidenecyanoacetate and 3-carboxy coumarin derivatives under
rt stirring and microwave irradiation in a very economical way. The developed method is found
to be simple and robust, non-hazardous and solvent-free to obtain the target product.

Conclusion:

In conclusion, we have established an efficient, simple, agro-waste based catalytic approach
for the synthesis of ethylbenzylidenecyanoacetate and 3-carboxy coumarin derivatives employing
WEWFPA as an efficient catalyst under rt stirring and microwave synthesis. The method
is a green, economical and eco-friendly approach for the synthesis of Knoevenagel condensation
products. The advantages of the present approach are that the reaction is a solvent-free synthesis, requiring
no external metal catalyst, chemical base free, short reaction time and excellent yield of
product. The catalyst is agro-waste derived, which is abundant in nature, thus making the present
approach a greener one.
Analysis of the influence of fundamental and external factors on stock prices in mining sector companies listed on the Indonesia stock exchange
Authors: Putra Andri Setia , Adam Mohamad , Widiyanti Marlina , Wahyudi Tertiarto
Published: December 2021

This study aimed to determine the effect of liquidity ratios (LR), solvency (DER), profitability (ROE), valuation ratios (PBV), inflation, and interest rates on stock prices of mining sector companies listed on the Indonesia Stock Exchange (IDX). The research sample is 41 mining sector companies with a research period from 2015-2019. The results show that the liquidity ratio (CR) and solvency (DER) have no significant effect on stock prices of mining sector companies in 2015-2019. The variable profitability (ROE), valuation ratio (PBV) was concluded to have a significant positive effect on stock prices of mining sector companies in 2015-2019. Meanwhile, inflation and interest rates have a significant adverse effect on stock prices of mining sector companies in 2015-2019.
literature of transition period and the upbringing of the youth
Authors: Biloldinovich Shahobov Kamoldin
Published: December 2021

The article analyzes the concept of transition in the Uzbek literature, the importance of the works created at different stages of the transition period on the education of the youth, and the artistic interpretation of social problems in the transition period. The transformation to the market economy has also influenced the lifestyle of people that it has been even seen in the relationships of people living in different ways, facing financial difficulties or profits to earn that a lot of people who have left to work abroad, is also the majority of the works described in modern Uzbek prose. Such novels are "Isyonvaitoat" by U.Hamdam, the novel of "Mashaqqatlargirdobi" by Zulfiya the daughter of Qurolboy. In conclusion, it can be said that the study and interpretation of the social problems raised in the literature of the transitional period are of great importance in the education of young people. The teacher, mentor's role is also unique in teaching such interpretations to students, to young people in the right direction, to teach them to feel love towards and to love the art.
The responsibility for performing civil service of the local civil servants in Vietnam
Authors: Trung Ngo Sy
Published: December 2021

The study was carried out by qualitative method through collecting secondary data, combined with quantitative method through surveying opinions of 450 managers of 250 representative commune-level government agencies for three regions of the country. Research results have confirmed: Attitude to serve the people (ASP) plays the most important role and has the strongest influence on the responsibilities for performing civil service of civil servants; Next is work responsibility (WR) and work consciousness (WC). From the results of this study, the author suggests some contents that need to be researched and adjusted for managers to improve the quality of local civil servants to meet the requirements of serving the people.
Living wage for workers in conditions of industrial development in Vietnam
Authors: Tung Phuong Huu
Published: December 2021

The living wage is defined by researchers as the salary that workers receive during normal working hours, which is enough to maintain a decent standard of living for themselves and their families. Therefore, it is different from the concept of minimum wage being applied as a basis for paying wages to workers today. Vietnam's minimum wage is calculated as the minimum to escape poverty, but not the minimum wage to ensure a decent minimum living in a developed economy. The minimum level to escape poverty is often applied in the condition that the country prioritizes economic development, but in the current period, the minimum wage must be a living wage to realize inclusive and inclusive development. leave behind. In the condition that Vietnam has become a middle-income country, the minimum wage Vietnam needs to aim for must be a living minimum wage. Therefore, this article analyzes the basis of paying a living wage for workers in Vietnam in the context of changing the economic model from the traditional to the industrial development model in Vietnam today.
Relación entre la riqueza de especies arbóreas y el cambio climático en el sureste de México
Authors: Santillán-Fernández Alberto , Escobar-Castillo Judith , Ireta-Paredes Arely del Rocío , Espinosa-Grande Ezequiel , Bautista-Ortega Jaime , Chávez-Vergara Bruno Manuel
Published: December 2021

El sureste de México es la región con la mayor riqueza de especies arbóreas en el país y potencialmente vulnerable a los efectos del clima futuro, por lo cual el objetivo de este trabajo fue relacionar la riqueza de especies y su modificación ante un escenario de cambio climático en el sureste de México. Para este fin se modeló, mediante MaxEnt, la distribución potencial actual y ante el cambio climático de 760 especies arbóreas. Actualmente, el incremento de temperatura puede afectar negativamente la distribución potencial de las especies. Los modelos de cambio climático para 2050 sugieren un incremento en la temperatura, ante lo cual la cobertura arbórea se reducirá; en el caso de las especies que coexisten en selva tropical, se concentrarían en el centro de la región, mientras que, para las especies de bosque templado, se pronostica una reducción mayor a 95% del área actual. Sin embargo, se observó que las áreas donde coexiste un mayor número de especies tienden a desarrollar una menor contracción de su área de distribución ante las variaciones climáticas futuras.
Lineamientos de ordenamiento y desarrollo territorial para Sincelejo desde el modelo de territorios inteligentes
Authors: Buelvas-Salgado Jenny Milena
Published: December 2021

La ciudad de Sincelejo, Colombia, al estar catalogada de ciudad emergente con una población intermedia, se plantea que podría proyectar su desarrollo económico, social y físico-construido a partir de los modelos estratégicos que definen a los territorios inteligentes, por lo que —como objetivo principal de esta Investigación— se pretende identificar los Lineamientos de Ordenamiento y Desarrollo Territorial para Sincelejo desde el Modelo Conceptual Territorio Inteligente, según una metodología estratégica. Los resultados develan un estado del arte que lleva a identificar brechas criticas para los subsistemas del modelo y, en consecuencia, a proponer mejoras para Sincelejo.
Mobile Device Ownership, Current Use, and Interest in Mobile Health Interventions Among Low-Income Older Chinese Immigrants With Type 2 Diabetes: Cross-sectional Survey Study
Authors: Hu Lu , Trinh-Shevrin Chau , Islam Nadia , Wu Bei , Cao Shimin , Freeman Jincong , Sevick Mary Ann
Published: December 2021

Background

Chinese immigrants suffer a disproportionately high type 2 diabetes (T2D) burden and tend to have poorly controlled disease. Mobile health (mHealth) interventions have been shown to increase access to care and improve chronic disease management in minority populations. However, such interventions have not been developed for or tested in Chinese immigrants with T2D.

Objective

This study aims to examine mobile device ownership, current use, and interest in mHealth interventions among Chinese immigrants with T2D.

Methods

In a cross-sectional survey, Chinese immigrants with T2D were recruited from Chinese community centers in New York City. Sociodemographic characteristics, mobile device ownership, current use of social media software applications, current use of technology for health-related purposes, and interest in using mHealth for T2D management were assessed. Surveys were administered face-to-face by bilingual study staff in the participant’s preferred language. Descriptive statistics were used to characterize the study sample and summarize technology use.

Results

The sample (N=91) was predominantly female (n=57, 63%), married (n=68, 75%), and had a high school education or less (n=58, 64%); most participants had an annual household income of less than US $25,000 (n=63, 69%) and had limited English proficiency (n=78, 86%). The sample had a mean age of 70 (SD 11) years. Almost all (90/91, 99%) participants had a mobile device (eg, basic cell phones, smart devices), and the majority (n=83, 91%) reported owning a smart device (eg, smartphone or tablet). WeChat was the most commonly used social media platform (65/91, 71%). When asked about their top source for diabetes-related information, 63 of the 91 participants (69%) reported health care providers, followed by 13 who reported the internet (14%), and 10 who reported family, friends, and coworkers (11%). Less than one-quarter (21/91, 23%) of the sample reported using the internet to search for diabetes-related information in the past 12 months. About one-third of the sample (34/91, 37%) reported that they had watched a health-related video on their cell phone or computer in the past 12 months. The majority (69/91, 76%) of participants reported interest in receiving an mHealth intervention in the future to help with T2D management.

Conclusions

Despite high mobile device ownership, the current use of technology for health-related issues remained low in older Chinese immigrants with T2D. Given the strong interest in future mHealth interventions and high levels of social media use (eg, WeChat), future studies should consider how to leverage these existing low-cost platforms and deliver tailored mHealth interventions to this fast-growing minority group.