bluuebunny/crossref_metadata_2025 huggingface dataset:
Criteria for return to running after anterior cruciate ligament reconstruction: a scoping review
Authors: Rambaud Alexandre J M , Ardern Clare L , Thoreux Patricia , Regnaux Jean-Philippe , Edouard Pascal
Published: May 2018

Objective

To describe the criteria used to guide clinical decision-making regarding when a patient is ready to return to running (RTR) after ACL reconstruction.

Design

Scoping review.

Data sources

The MEDLINE (PubMed), EMBASE, Web of Science, PEDro, SPORTDiscus and Cochrane Library electronic databases. We also screened the reference lists of included studies and conducted forward citation tracking.

Eligibility criteria for selecting studies

Reported at least one criterion for permitting adult patients with primary ACL reconstruction to commence running postoperatively.

Results

201 studies fulfilled the inclusion criteria and reported 205 time-based criteria for RTR. The median time from when RTR was permitted was 12 postoperative weeks (IQR=3.3, range 5–39 weeks). Fewer than one in five studies used additional clinical, strength or performance-based criteria for decision-making regarding RTR. Aside from time, the most frequently reported criteria for RTR were: full knee range of motion or >95% of the non-injured knee plus no pain or pain <2 on visual analogue scale; isometric extensor limb symmetry index (LSI)>70% plus extensor and flexor LSI>70%; and hop test LSI>70%.

Conclusions

Fewer than one in five studies reported clinical, strength or performance-based criteria for RTR even though best evidence recommends performance-based criteria combined with time-based criteria to commence running activities following ACL reconstruction.
Subjects with cardiovascular disease or high disease risk are more sedentary and less active than their healthy peers
Authors: Vasankari Ville , Husu Pauliina , Vähä-Ypyä Henri , Suni Jaana Helena , Tokola Kari , Borodulin Katja , Wennman Heini , Halonen Jari , Hartikainen Juha , Sievänen Harri , Vasankari Tommi
Published: May 2018

Objectives

We investigated differences in objectively measured sedentary behaviour (SB) and physical activity (PA) levels in subjects with cardiovascular disease (CVD) diagnosis or high CVD risk compared with healthy controls.

Methods

The present study includes a subsample (n=1398, Health 2011 Study) of participants, who attended health examinations and wore a triaxial accelerometer (≥4 days). Patients with CVD were identified and CVD risk was calculated for others using Framingham Risk Score (FRS). Participants were categorised into groups: FRS<10%; FRS=10%–30%; FRS>30%/CVD. Raw acceleration data were analysed with mean amplitude deviation (MAD) and angle for posture estimation (APE). MAD corresponding to intensity of PA was converted to metabolic equivalents (MET) and categorised to light (1.5–2.9 METs) and moderate to vigorous PA (MVPA≥3.0 METs). APE recognises SB and standing.

Results

Daily accumulated time of >30 s MVPA bouts was higher in FRS<10% group (46 min) than in FRS>30%/CVD group (29 min) (p<0.001). FRS>30%/CVD group were more sedentary, their mean daily number of >10 min SB bouts (13.2) was higher than in FRS <10% group (11.5) (p=0.002).

Conclusion

Number and accumulated times of SB and PA bouts differed between the CVD risk groups. Causative research is required to assess the importance of SB and PA in prevention and rehabilitation of CVDs.
Smad4/DPC4
Authors: McCarthy Aoife J , Chetty Runjan
Published: May 2018

Smad4 or DPC4 belongs to a family of signal transduction proteins that are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor beta (TGF-β) signaling via several pathways. The gene acts as a tumour suppressor gene and inactivation ofsmad4/DPC4is best recognised in pancreatic cancer. However,smad4/DPC4is also mutated in other conditions and cancers such as juvenile polyposis syndrome with and without hereditary haemorrhagic telangiectasia, colorectal and prostate cancers.

Immunohistochemistry for smad4/DPC4 protein is most useful in separating benign/reactive conditions from pancreatic cancer in needle/core biopsies. In normal and reactive states, the protein is localised to the cytoplasm and nucleus, while the protein is lost in high-grade pancreatic intraepithelial neoplasia/carcinoma in situ and pancreatic cancer.
Access to radical resections of pancreatic cancer is region-dependent despite the public healthcare system in Finland
Authors: Ahola Reea , Hölsä Heini , Kiskola Samuli , Ojala Pirkka , Pirttilä Aino , Sand Juhani , Laukkarinen Johanna
Published: May 2018

Background

Surgical resection is the best treatment option to improve the prognosis of pancreatic cancer (PC). Our aim was to analyse whether PC treatment strategies show regional variation in Finland, a country with a nationwide public healthcare system.

Methods

All patients diagnosed with PC in 2003 and 2008 were identified from the Finnish Cancer Registry. The data regarding tumour, treatment, demographics and timespans to treatment were recorded from the patient archives. Patients were included in the healthcare district where the diagnosis was made. The healthcare districts were classified according to experience in pancreatic surgery into three groups (high level of experience region (HLER), n=2; medium level of experience region (MLER), n=6, and low level of experience region (LLER), n=13).

Results

Patients included numbered 1546 (median age 72 years (range 34–97), 45% men). Demographics and the ratio of stage IV disease (53%) were similar between the regional groups. Despite this, the proportion of radical surgery was greater in HLERs than in the MLERs and LLERs (18% vs 8%–11%; p<0.01). Logistic regression analysis including age, American Society of Anesthesiologists classification, stage and level of experience showed that more radical resections were performed in the HLERs. Preoperative bile drainage showed no regional differences (p=0.137). Palliative chemotherapy only was used more frequently in MLER and LLER than in HLERs (24% vs 33%–30%; p<0.01).

Conclusion

Access to PC curative treatment was more likely for patients in healthcare districts including a hospital with high level of experience in pancreatic surgery. This highlights the importance of centralized treatment guidance.
Finding a path to growth as a leader: a medical learner perspective
Authors: Benrimoh David A , Bohnen Jordan D , Hall Justin N
Published: May 2018

Physicians are often required to lead teams in clinical and non-clinical environments but may not receive formal training in advance of these opportunities. In this commentary, three medical learners discuss their views on leadership education in undergraduate and postgraduate medicine, arguing that leadership development should be more explicitly integrated into training programmes and that medical leaders need to be better recognised for their contributions to this field, much like expert clinicians, clinician-educators and clinician-scientists are recognised for theirs. After reviewing the published literature in this domain, reflecting on their experiences engaging with medical leaders and attending a leadership education summit, the authors conclude that, as initial steps towards improving leadership training in medical education, faculties and programmes should commit to incorporating leadership training into their curricula, and strive to deliberately connect learners interested in leadership with practising clinician-leaders with an eye towards improving learners’ leadership skills. These first steps could help to catalyse the necessary shift towards improved leadership education and better patient care.
Rates of pelvic inflammatory disease and ectopic pregnancy in Australia, 2009–2014: ecological analysis of hospital data
Authors: Goller Jane L , De Livera Alysha M , Guy Rebecca, J , Low Nicola , Donovan Basil , Law Matthew , Kaldor John M , Fairley Christopher K , Hocking Jane S
Published: May 2018

Objective

To analyse yearly rates of pelvic inflammatory disease (PID) and ectopic pregnancy (EP) diagnosed in hospital settings in Australia from 2009 to 2014.

Methods

We calculated yearly PID and EP diagnosis rates in three states (Victoria, New South Wales, Queensland) for women aged 15–44 years using hospital admissions and emergency department (ED) attendance data, with population and live birth denominators. We stratified PID diagnoses as chlamydial-related or gonorrhoeal-related (Chlamydia trachomatis (CT)-related or Neisseria gonorrhoeae (NG)-related), acute, unspecified and chronic, and analysed variations by year, age and residential area using Poisson regression models.

Results

For PID, the rate of all admissions in 2014 was 63.3 per 100 000 women (95% CI 60.8 to 65.9) and of all presentations in EDs was 97.0 per 100 000 women (95% CI 93.9 to 100.2). Comparing 2014 with 2009, the rate of all PID admissions did not change, but the rate of all presentations in EDs increased (adjusted incidence rate ratio (aIRR) 1.34, 95% CI 1.24 to 1.45), and for admissions by PID category was higher for CT-related or NG-related PID (aIRR 1.73, 95% CI 1.31 to 2.28) and unspecified PID (aIRR 1.09, 95% CI 1.00 to 1.19), and lower for chronic PID (aIRR 0.84, 95% CI 0.74 to 0.95). For EP, in 2014 the rate of all admissions was 17.4 (95% CI 16.9 to 17.9) per 1000 live births and of all ED presentations was 15.6 (95% CI 15.1 to 16.1). Comparing 2014 with 2009, the rates of all EP admissions (aIRR 1.06, 95% CI 1.04 to 1.08) and rates in EDs (aIRR 1.24, 95% CI 1.18 to 1.31) were higher.

Conclusions

PID and EP remain important causes of hospital admissions for female STI-associated complications. Hospital EDs care for more PID cases than inpatient departments, particularly for young women. Updated primary care data are needed to better understand PID epidemiology and healthcare usage.
Assessing genetic diversity of various Canadian sheep breeds through pedigree analyses
Authors: Stachowicz Katarzyna , Brito Luiz F. , Oliveira Hinayah R. , Miller Stephen P. , Schenkel Flávio S.
Published: May 2018

The loss of genetic variability in a population will drastically affect the success of a breeding program by reducing selection response and fitness and, consequently, affecting reproduction, resilience, and production efficiency. The objective of this study was to perform an in-depth analysis of the pedigree of the Canadian sheep breeds to assess the levels of inbreeding, effective population size, and other metrics of genetic diversity, which included the five most important sheep breeds in Canada: Dorset, Polypay (PO), Rideau-Arcott, Romanov (RV), and Suffolk, using a large dataset (1 336 926 animals). As measures of genetic diversity, effective population size, inbreeding coefficient, effective number of founders, effective number of founder genomes, effective number of nonfounders, and effective number of ancestors were estimated. The completeness and depth of the Canadian sheep pedigree datasets were reasonably high, with <20% parental information missing. More attention should be given to PO breed, which was found to have the smallest effective population size (55), and RV breed, which had the highest average level of inbreeding (4.8%). Techniques such as optimum contribution selection and minimum coancestry mating could be used to minimize the inbreeding of future generations, while maintaining genetic progress at a desirable level.
Phenology of hatching, emergence, and end-of-season body size in young-of-year coho salmon in thermally contrasting streams draining the Copper River Delta, Alaska
Authors: Campbell Emily Y. , Dunham Jason B. , Reeves Gordon H. , Wondzell Steve M.
Published: May 2018

Phenology can be linked to individual fitness, particularly in strongly seasonal environments where the timing of events has important consequences for growth, condition, and survival. We studied the phenology of coho salmon (Oncorhynchus kisutch) hatching and emergence in streams with contrasting thermal variability but in close geographic proximity. Following emergence, we tracked body sizes of cohorts of young-of-year fish until the end of the growing season. Hatch and emergence occurred at the same time among streams with marked variability in thermal regimes. We demonstrate that this can be explained in part by the thermal units accumulated during embryo development. At the end of the first growing season, there were some differences in body size, but overall fish size was similar among streams despite strong differences in thermal regimes. Collectively, these results provide novel insights into the interactions between environmental variability and the early life-history stages of coho salmon, furthering our understanding of the consequences of phenology on growth and survival for individuals within the critical first summer of life.
Compression of a mixed antiproton and electron non-neutral plasma to high densities
Authors: Aghion Stefano , Amsler Claude , Bonomi Germano , Brusa Roberto S. , Caccia Massimo , Caravita Ruggero , Castelli Fabrizio , Cerchiari Giovanni , Comparat Daniel , Consolati Giovanni , Demetrio Andrea , Di Noto Lea , Doser Michael , Evans Craig , Fanì Mattia , Ferragut Rafael , Fesel Julian , Fontana Andrea , Gerber Sebastian , Giammarchi Marco , Gligorova Angela , Guatieri Francesco , Haider Stefan , Hinterberger Alexander , Holmestad Helga , Kellerbauer Alban , Khalidova Olga , Krasnický Daniel , Lagomarsino Vittorio , Lansonneur Pierre , Lebrun Patrice , Malbrunot Chloé , Mariazzi Sebastiano , Marton Johann , Matveev Victor , Mazzotta Zeudi , Müller Simon R. , Nebbia Giancarlo , Nedelec Patrick , Oberthaler Markus , Pacifico Nicola , Pagano Davide , Penasa Luca , Petracek Vojtech , Prelz Francesco , Prevedelli Marco , Rienaecker Benjamin , Robert Jacques , Røhne Ole M. , Rotondi Alberto , Sandaker Heidi , Santoro Romualdo , Smestad Lillian , Sorrentino Fiodor , Testera Gemma , Tietje Ingmari C. , Widmann Eberhard , Yzombard Pauline , Zimmer Christian , Zmeskal Johann , Zurlo Nicola , Antonello Massimiliano
Published: May 2018

We describe a multi-step “rotating wall” compression of a mixed cold antiproton–electron non-neutral plasma in a 4.46 T Penning–Malmberg trap developed in the context of the AEḡIS experiment at CERN. Such traps are routinely used for the preparation of cold antiprotons suitable for antihydrogen production. A tenfold antiproton radius compression has been achieved, with a minimum antiproton radius of only 0.17 mm. We describe the experimental conditions necessary to perform such a compression: minimizing the tails of the electron density distribution is paramount to ensure that the antiproton density distribution follows that of the electrons. Such electron density tails are remnants of rotating wall compression and in many cases can remain unnoticed. We observe that the compression dynamics for a pure electron plasma behaves the same way as that of a mixed antiproton and electron plasma. Thanks to this optimized compression method and the high single shot antiproton catching efficiency, we observe for the first time cold and dense non-neutral antiproton plasmas with particle densities n ≥ 1013 m−3, which pave the way for an efficient pulsed antihydrogen production in AEḡIS.

Graphical abstract
Unsteady RANS/DES analysis of flow around helicopter rotor blades at forword flight conditions
Authors: Zhang Zhenyu , Qian Yaoru
Published: May 2018

In this paper, the complex flows around forward-flying helicopter blades are numerically investigated. Both the Reynolds-averaged Navier–Stokes (RANS) and the Detached Eddy Simulation (DES) methods are used for the analysis of characteristics like local dynamic flow separation, effects of radial sweeping and reversed flow. The flow was solved by a highly efficient finite volume solver with multi-block structured grids. Focusing upon the complexity of the advance ratio effects, above properties are fully recognized. The current results showed significant agreements between both RANS and DES methods at phases with attached flow phases. Detailed information of separating flow near the withdrawal phases are given by DES results. The flow analysis of these blades under reversed flow reveals a significant interaction between the reversed flow and the span-wise sweeping.
Fission and fusion interaction phenomena of mixed lump kink solutions for a generalized (3+1)-dimensional B-type Kadomtsev–Petviashvili equation
Authors: Liu Yaqing , Wen Xiaoyong
Published: May 2018

In this paper, a generalized (3[Formula: see text]+[Formula: see text]1)-dimensional B-type Kadomtsev–Petviashvili (gBKP) equation is investigated by using the Hirota’s bilinear method. With the aid of symbolic computation, some new lump, mixed lump kink and periodic lump solutions are derived. Based on the derived solutions, some novel interaction phenomena like the fission and fusion interactions between one lump soliton and one kink soliton, the fission and fusion interactions between one lump soliton and a pair of kink solitons and the interactions between two periodic lump solitons are discussed graphically. Results might be helpful for understanding the propagation of the shallow water wave.
Chiral Magnetic Effect Search in p(d)+Au, Au+Au Collisions at RHIC
Authors: Zhao Jie
Published: May 2018

The chiral magnetic effect (CME) refers to charge separation along a strong magnetic field of single-handed quarks, caused by interactions with topological gluon fields from QCD vacuum fluctuations. A major background of CME measurements in heavy-ion collisions comes from resonance decays coupled with elliptical flow anisotropy. These proceedings present two new studies from STAR to shed further light on the background issue: (1) small system p+Au and d+Au collisions where the CME signal is not expected, and (2) pair invariant mass dependence where resonance peaks can be identified.
Longitudinal Double Spin Asymmetries of π0 - Jet Correlations in Polarized Proton Collisions at s = 510 GeV at STAR
Authors: Wang Yaping
Published: May 2018

One of the primary goals of the spin physics program at STAR is to constrain the polarized gluon distribution function, [Formula: see text], by measuring the longitudinal double-spin asymmetry ([Formula: see text]) of various final-state channels. Using a jet in the mid-rapidity region [Formula: see text] correlated with an azimuthally back-to-back [Formula: see text] in the forward rapidity region [Formula: see text] provides a new possibility to access the [Formula: see text] distribution at Bjorken-[Formula: see text] down to 0.01. Compared to inclusive jet or inclusive [Formula: see text] measurements, this channel also allows to constrain the initial parton kinematics. In these proceedings, we will present the status of the analysis of the [Formula: see text]-jet [Formula: see text] in longitudinally polarized proton+proton collisions at [Formula: see text] =510 GeV with 80 pb[Formula: see text] of data taken during the 2012 RHIC run. We also compare the projected [Formula: see text] uncertainties to theoretical predictions of the [Formula: see text] by next-to-leading order (NLO) model calculations with different polarized parton distribution functions.
Light Hadron Spectroscopy at BESIII
Authors: Huang Xingtao
Published: May 2018

BESIII has collected [Formula: see text] and [Formula: see text] of [Formula: see text], which are the world’s largest data samples of [Formula: see text] and [Formula: see text] from [Formula: see text] collision. Radiative decays of charmonium provide a gluon-rich environment and are therefore regarded as one of the most promising hunting grounds for gluonic excitations. Significant progresses in the light-quark sector have been made with the unprecedented high statistics data sets. Several recent results on light hadron spectroscopy and light hadron decays will be reported, including: 1, the observation of the anomalous line shape of [Formula: see text] near [Formula: see text] mass threshold and related studies; 2, studies of glueballs in [Formula: see text] radiative decays; 3, search for [Formula: see text] exotic in [Formula: see text].
Form Factor Measurements at BESIII for an Improved Standard Model Prediction of the Muon g-2
Authors: Destefanis Marco
Published: May 2018

The anomalous part of the magnetic moment of the muon, (g-2)[Formula: see text], allows for one of the most precise tests of the Standard Model of particle physics. We report on recent results by the BESIII Collaboration of exclusive hadronic cross section channels, such as the 2[Formula: see text], 3[Formula: see text], and 4[Formula: see text] final states. These measurements are of utmost importance for an improved calculation of the hadronic vacuum polarization contribution of (g-2)[Formula: see text], which currenty is limiting the overall Standard Model prediction of this quantity. BESIII has furthermore also intiatated a programme of spacelike transition form factor measurements, which can be used for a determination of the hadronic light-by-light contribution of (g-2)[Formula: see text] in a data-driven approach. These results are of relevance in view of the new and direct measurements of (g-2)[Formula: see text] as foreseen at Fermilab/USA and J-PARC/Japan.
d∗(2380) Resonance in a Chiral SU(3) Constituent Quark Model
Authors: Dong Yubing , Shen Pengnian , Huang Fei , Zhang Zongye
Published: May 2018

Recent studies on the newly observed resonance [Formula: see text] with a compact structure in a chiral SU(3) constituent quark model are briefly reported. the overall properties, including the mass, the partial decay widths in various decay modes, and the total width, comparing with the experimental data, show that a compact hexaquark dominated structure might be a reasonable interpretation for this state. Moreover, the charge distribution of [Formula: see text] is also discussed.
Measurements of the Reactor Antineutrino with Solid State Scintillation Detector
Authors: Alekseev I. , Belov V. , Brudanin V. , Danilov M. , Egorov V. , Filosofov D. , Fomina M. , Hons Z. , Kazartsev S. , Kobyakin A. , Kuznetsov A. , Machikhiliyan I. , Medvedev D. , Nesterov V. , Olshevsky A. , Pogorelov N. , Ponomarev D. , Rozova I. , Rumyantseva N. , Rusinov V. , Salamatin A. , Samigullin E. , Shevchik Ye. , Shirchenko M. , Shitov Yu. , Skrobova N. , Starostin A. , Svirida D. , Tarkovsky E. , Tikhomirov I. , Vlášek J. , Zhitnikov I. , Zinatulina D.
Published: May 2018

Measurements of reactor antineutrino play an important role in the efforts at the frontier of the modern physics. The DANSS collaboration presents preliminary results of a one year run with a cubic meter solid state detector placed below 3.1 GW industrial light water reactor. The experiment is sensitive to sterile neutrino in the most interesting region of mixing parameter space. 2500 scintillation strips of the sensitive volume of the detector have multilayer passive shielding of copper, lead and borated polyethylene and active muon veto. Detector position below the reactor gives an advantage of overburden about 50 m of water equivalent providing factor of six in cosmic muon suppression and eliminating fast neutrons.The detector is placed on a vertically movable platform which allows to change the distance to the reactor core center in the range 10.7-12.7 m within a few minutes. The strips are read out individually by SiPMs and in groups of 50 by PMTs. 5000 inverse beta-decay events per day are collected in the fiducial volume, which is 78% of the whole detector, at the position closest to the reactor. Overburden, active veto and good segmentation of the detector result in an excellent signal to background ratio.

The talk is dedicated to the data analysis and preliminary results. The experiment status is also presented.
Dark Photon Searches at BESIII
Authors: Wang Dayong
Published: May 2018

Many models beyond the Standard Model, motivated by the recent astrophysical anomalies, predict a new type of weak-interacting degrees of freedom. Typical models include the possibility of the low-mass dark gauge bosons of a few GeV and thus making them accessible at the BESIII experiment running at the tau-charm region. The BESIII has recently searched such dark bosons in several decay modes using the high statistics data set collected at charmonium resonaces. This talk will summarize the recent BESIII results of these dark photon searches and related new physics studies.
Top Quark Mass and Properties Measurements with the ATLAS Detector
Authors: Moreno Llácer M.
Published: May 2018

The top quark is the heaviest elementary particle and unique among the known quarks since it decays before forming hadronic bound states. This makes measurements of the top quark itself particularly interesting as one can access directly the properties of a bare quark. The latest measurements of these properties with the ATLAS detector are reported using data from 8 TeV and 13 TeV proton-proton collisions at the Large Hadron Collider at CERN. The latest measurements of the top quark mass using template methods, as well as others aiming to measure the mass in a well-defined scheme, are presented. In addition, measurements for the top quark decay width, top quark spin observables and [Formula: see text]-boson helicity in events with top quark pairs ([Formula: see text]) are presented and compared to the Standard Model predictions. The cross-section measurements of top quark pair production in association with a photon, [Formula: see text]- or [Formula: see text]-boson are also reported and compared to the most accurate theoretical calculations. These measurements probe the top quark electroweak couplings. Limits on the rate of flavour-changing neutral current processes in the production or decay of the top quark are also shown.
CP Violation in b Hadrons at LHCb
Authors: Hicheur A.
Published: May 2018

The most recent results on CP violation in [Formula: see text] hadrons obtained by the LHCb Collaboration with Run I and years 2015-2016 of Run II are reviewed. The different types of violation are covered by the studies presented in this paper.
Measurements of Properties of Antihydrogen
Authors: Olin Art ,   M. Ahmadi, B.X.R. Alves, C.J. Baker, W. Bertsche, E. Butler, A. Capra, C. Carruth, A.E. Charman, L.T. Evans, C.L. Cesar, M. Charlton, S. Cohen, R. Collister, S. Eriksson, A. Evans, L.T. Evans, N. Evetts, J. Fajans, T. Friesen, M.C. Fujiwara, D.R. Gill, J.S. Hangst, W.N. Hardy, M.E. Hayden, C.A. Isaac, M.A. Johnson, J.M Jones, S.A. Jones, S. Jonsell, A. Khramov, P. Knapp, L. Kurchaninov, N. Madsen, D. Maxwell, J.T.K. McKenna, S.Menary, T. Momose, J.J. Munich, K. Olchanski, A. Olin, P. Pusa, C. Rasmussen, F.
Published: May 2018

The ALPHA project at the CERN AD is testing fundamental symmetries between matter and antimatter using trapped antihydrogen atoms. The spectrum of the antihydrogen atom may be compared to ordinary hydrogen where it has been measured very precisely. CPT conservation, which underpins our current theoretical framework, requires equality of the masses and charges of matter and its antimatter partners, so antihydrogen spectroscopy presents a path to precision CPT tests.

I will discuss the techniques used by ALPHA to trap more than 8000 antihydrogen atoms in 2016, and interrogate them for 600s. The 1S-2S transition in antihydrogen has been observed for the first time, and it agrees with its hydrogen counterpart within an uncertainty of 400 kHz or 0.2 ppb. The charge of the antihydrogen atom has been bounded below [Formula: see text]. A value of 1420.4 0.5MHz for the hyperfine splitting has been obtained from observation of the positron spin resonance spectrum.
Energy-Frontier Lepton-Hadron Collisions at CERN: The LHeC and the FCC-eh
Authors: Kuze Masahiro
Published: May 2018

Lepton-hadron colliders that use a proton or nucleus beam of current and future hadron colliders and let it collide with an electron beam from a newly built electron accelerator bring attractive physics programs which are strong and complementary to the hadron collider physics. Machine development for Energy Recovery LINAC and physics performance studies of such electron-hadron colliders, specifically the LHeC that uses the existing LHC beam and FCC-eh that is an option of Future Circular Collider program, are ongoing and reviewed in this article.
The Belle II Experiment: Status and Physics Prospects
Authors: Bennett Jake
Published: May 2018

The Belle II experiment is now under construction at the KEK laboratory in Japan. This project represents a substantial upgrade to both the Belle detector and the KEKB accelerator. The Belle II experiment will record 50/ab of data, a factor of 50 more than that recorded by Belle. This large data set, combined with the low backgrounds and high trigger efficiencies characteristic of an [Formula: see text] experiment, should provide unprecedented sensitivity to new physics signatures in [Formula: see text] and [Formula: see text] meson decays, and in [Formula: see text] lepton decays. The experiment is scheduled to begin physics running in 2018.
Masses of Charmed and Bottom Tetraquarks in the Non-Relativistic Quark Model
Authors: Ghalenovi Zahra
Published: May 2018

Heavy tetraquark states are studied within the diquark-antidiquark picture in the framework of a simple constituent quark model. Considering hyperfine spin and isospin interactions, we predict the masses of the scalar diquarks and of the open and hidden charmed and bottom scalar tetraquarks. Our results indicate the scalar resonances [Formula: see text] and [Formula: see text] have a sizable tetraquark amount in their wave function, while it turns out the scalar state [Formula: see text] should not be considered as being predominately diquark-antidiquark bound states.
Study of Deuteron System in a Two-Body Potential Model
Authors: Ghalenovi Zahra , Tavakolinezhad Asadolah
Published: May 2018

In this work, we study the Hamiltonian of Deuteron as a two-body system and solve the equation of the system in the non-relativistic limit. We obtain the ground state wave function as well as the corresponding energy eigenvalue of the deuteron system. The considered potentials are a combination of the confinement, Coulomb-like (as the one arising from one gluon exchange) and Goldstone boson exchange interaction.
3D numerical modelling of the Wilson cycle: structural inheritance of alternating subduction polarity
Authors: Beaussier Stéphane J. , Gerya Taras V. , Burg Jean-Pierre
Published: May 2018

Alternating subduction polarity along suture zones has been documented in several orogenic systems. Yet the mechanisms leading to this geometric inversion and the subsequent interplay between the contra-dipping slabs have been little studied. To explore such mechanisms, 3D numerical modelling of the Wilson cycle was conducted from continental rifting, breakup and oceanic spreading to convergence and self-consistent subduction initiation. In the resulting models, near-ridge subduction initiating with the formation of contra-dipping slab segments is an intrinsically 3D process controlled by earlier convergence-induced ridge swelling. The width of the slab segments is delimited by transform faults inherited from the rifting and ocean floor spreading stages. The models show that the number of contra-dipping slab segments depends mainly on the size of the oceanic basin, the asymmetry of the ridge and variations in kinematic inversion from divergence to convergence. Convergence velocity has been identified as a second-order parameter. The geometry of the linking zone between contra-dipping slab segments varies between two end-members governed by the lateral coupling between the adjacent slab segments: (1) coupled slabs generate wide, arcuate linking zones holding two-sided subduction; and (2) decoupled slabs generate narrow transform fault zones against which one-sided, contra-dipping slabs abut.
Reappraisal of the magma-rich versus magma-poor rifted margin archetypes
Authors: Tugend Julie , Gillard Morgane , Manatschal Gianreto , Nirrengarten Michael , Harkin Caroline , Epin Marie-Eva , Sauter Daniel , Autin Julia , Kusznir Nick , McDermott Ken
Published: May 2018

Rifted margins are commonly defined as magma-poor or magma-rich archetypes based on their morphology. We re-examine the prevailing model inferred from this classification that magma-rich margins have excess decompression melting at lithospheric breakup compared with steady-state seafloor spreading, while magma-poor margins have inhibited melting. We investigate the magmatic budget related to lithospheric breakup along two high-resolution long-offset deep reflection seismic profiles across the SE Indian (magma-poor) and Uruguayan (magma-rich) rifted margins.

Resolving the magmatic budget is difficult and several interpretations can explain our seismic observations, implying different mechanisms to achieve lithospheric breakup and melt production for each archetype. We show that the Uruguayan and other magma-rich margins may indeed involve excess decompression melting compared with steady-state seafloor spreading but could also be explained by a gradual increase with an early onset relative to crustal breakup. A late onset of decompression melting relative to crustal breakup enables mantle exhumation characteristic of magma-poor margin archetypes (e.g. SE India).

Despite different volumes of magmatism, the mechanisms suggested at lithospheric breakup are comparable between both archetypes. Considerations on the timing of decompression melting onset relative to crustal thinning may be more important than the magmatic budget to understand the evolution and variability of rifted margins.
The April 2018 issue
Authors: Bonaventure Olivier
Published: May 2018

The April 2018 issue of SIGCOMM Computer Communication Review.
Scanning the Internet for Liveness
Authors: Bano Shehar , Richter Philipp , Javed Mobin , Sundaresan Srikanth , Durumeric Zakir , Murdoch Steven J. , Mortier Richard , Paxson Vern
Published: May 2018

Internet-wide scanning depends on a notion of liveness: does a target IP address respond to a probe packet? However, the interpretation of such responses, or lack of them, is nuanced and depends on multiple factors, including: how we probed, how different protocols in the network stack interact, the presence of filtering policies near the target, and temporal churn in IP responsiveness. Although often neglected, these factors can significantly affect the results of active measurement studies. We develop a taxonomy of liveness which we employ to develop a method to perform concurrent IPv4 scans using ICMP, five TCP-based, and two UDP-based protocols, comprehensively capturing all responses to our probes, including negative and cross-layer responses. Leveraging our methodology, we present a systematic analysis of liveness and how it manifests in active scanning campaigns, yielding practical insights and methodological improvements for the design and the execution of active Internet measurement studies.
Cationic control of Panx1 channel function
Authors: Wang Junjie , Jackson David George , Dahl Gerhard
Published: May 2018

The sequence and predicted membrane topology of pannexin1 (Panx1) places it in the family of gap junction proteins. However, rather than forming gap junction channels, Panx1 forms channels in the nonjunctional membrane. Panx1 operates in two distinct open states, depending on the mode of stimulation. The exclusively voltage-gated channel has a small conductance (<100 pS) and is highly selective for the flux of chloride ions. The Panx1 channel activated by various physiological stimuli or by increased concentrations of extracellular potassium ions has a large conductance (~500 pS, however, with multiple, long-lasting subconductance states) and is nonselectively permeable to small molecules, including ATP. To test whether the two open conformations also differ pharmacologically, the effects of di-and trivalent cations on the two Panx1 channel conformations were investigated. The rationale for this venture was that, under certain experimental conditions, ATP release from cells can be inhibited by multivalent cations, yet the literature indicates that the ATP release channel Panx1 is not affected by these ions. Consistent with previous reports, the Panx1 channel was not activated by removal of extracellular Ca2+ and the currents through the voltage-activated channel were not altered by Ca2+, Zn2+, Ba2+, or Gd3+. In contrast, the Panx1 channel activated to the large channel conformation by extracellular K+, osmotic stress, or low oxygen was inhibited by the multivalent cations in a dose-dependent way. Thus, monovalent cations activated the Panx1 channel from the closed state to the “large” conformation, while di- and trivalent cations exclusively inhibited this large channel conformation.
Placental ischemia-stimulated T-helper 17 cells induce preeclampsia-associated cytolytic natural killer cells during pregnancy
Authors: Shields Corbin A. , McCalmon Maggie , Ibrahim Tarek , White Dakota L. , Williams Jan M. , LaMarca Babbette , Cornelius Denise C.
Published: May 2018

Previous studies have demonstrated that T-helper 17 (TH17) cells and cytolytic natural killer (cNK) cells are increased in women with preeclampsia. In this study we investigated the role of placental ischemia-stimulated TH17 cells in induction of cNK cells in pregnancy. We further assessed the role of TH17 cell-mediated oxidative stress in facilitation of cNK cell activation in pregnancy by treating rats with the SOD mimetic tempol. CD4+/CD25− cells were isolated from reduced uterine perfusion pressure (RUPP) rats and differentiated into TH17 cells in vitro. On day 12 of gestation ( GD12), 1 × 106 placental ischemia-stimulated TH17 cells were injected into normal pregnant (NP) rats (NP + RUPP TH17 rats), and a subset of rats were treated with tempol (30 mg·kg−1·day−1) from GD12 to GD19 (NP + RUPP TH17 + tempol rats). On GD19, cNK cells, mean arterial pressure, fetal weight, and cNK cell-associated cytokines and proteins were measured. Placental cNK cells were 2.9 ± 1, 14.9 ± 4, and 2.8 ± 1.0% gated in NP, NP + RUPP TH17, and NP + RUPP TH17 + tempol rats, respectively. Mean arterial pressure increased from 96 ± 5 mmHg in NP rats to 118 ± 2 mmHg in NP + RUPP TH17 rats and was 102 ± 3 mmHg in NP + RUPP TH17 + tempol rats. Fetal weight was 2.37 ± 0.04, 1.95 ± 0.14, and 2.3 ± 0.05 g in NP, NP + RUPP TH17, and NP + RUPP TH17 + tempol rats, respectively. Placental IFNγ increased from 1.1 ± 0.6 pg/mg in NP rats to 3.9 ± 0.6 pg/mg in NP + RUPP TH17 rats. Placental perforin increased from 0.18 ± 0.18 pg/mg in NP rats to 2.4 ± 0.6 pg/mg in NP + RUPP TH17 rats. Placental levels of granzymes A and B followed a similar pattern. Treatment with tempol did not lower placental cNK cytokines or proteins. The results of the present study identify TH17 cells as a mediator of aberrant NK cell activation that is associated with preeclampsia.
Electrical excitability of roach (Rutilus rutilus) ventricular myocytes: effects of extracellular K+, temperature, and pacing frequency
Authors: Badr Ahmed , Abu-Amra El-Sabry , El-Sayed Mohamed F. , Vornanen Matti
Published: May 2018

Exercise, capture, and handling stress in fish can elevate extracellular K+concentration ([K+]o) with potential impact on heart function in a temperature- and frequency-dependent manner. To this end, the effects of [K+]oon the excitability of ventricular myocytes of winter-acclimatized roach ( Rutilus rutilus) (4 ± 0.5°C) were examined at different test temperatures and varying pacing rates. Frequencies corresponding to in vivo heart rates at 4°C (0.37 Hz), 14°C (1.16 Hz), and 24°C (1.96 Hz) had no significant effect on the excitability of ventricular myocytes. Acute increase of temperature from 4 to 14°C did not affect excitability, but a further rise to 24 markedly decreased excitability: stimulus current and critical depolarization needed to elicit an action potential (AP) were ~25 and 14% higher, respectively, at 24°C than at 4°C and 14°C ( P < 0.05). This depression could be due to temperature-related mismatch between inward Na+and outward K+currents. In contrast, an increase of [K+]ofrom 3 to 5.4 or 8 mM at 24°C reduced the stimulus current needed to trigger AP. However, other aspects of excitability were strongly depressed by high [K+]o: maximum rate of AP upstroke and AP duration were drastically (89 and 50%, respectively) reduced at 8 mM [K+]oin comparison with 3 mM ( P < 0.05). As an extreme case, some myocytes completely failed to elicit all-or-none AP at 8 mM [K+]oat 24°C. Also, amplitude and overshoot of AP were reduced by elevation of [K+]o( P < 0.05). Although high [K+]oantagonizes the negative effects of high temperature on excitation threshold, the precipitous depression of the rate of AP upstroke and complete loss of excitability in some myocytes suggest that the combination of high temperature and high [K+]owill severely impair ventricular excitability in roach.
ZnT2 is critical for lysosome acidification and biogenesis during mammary gland involution
Authors: Rivera Olivia C. , Hennigar Stephen R. , Kelleher Shannon L.
Published: May 2018

Mammary gland involution, a tightly regulated process of tissue remodeling by which a lactating mammary gland reverts to the prepregnant state, is characterized by the most profound example of regulated epithelial cell death in normal tissue. Defects in the execution of involution are associated with lactation failure and breast cancer. Initiation of mammary gland involution requires upregulation of lysosome biogenesis and acidification to activate lysosome-mediated cell death; however, specific mediators of this initial phase of involution are not well described. Zinc transporter 2 [ZnT2 ( SLC30A2)] has been implicated in lysosome biogenesis and lysosome-mediated cell death during involution; however, the direct role of ZnT2 in this process has not been elucidated. Here we showed that ZnT2-null mice had impaired alveolar regression and reduced activation of the involution marker phosphorylated Stat3, indicating insufficient initiation of mammary gland remodeling during involution. Moreover, we found that the loss of ZnT2 inhibited assembly of the proton transporter vacuolar ATPase on lysosomes, thereby decreasing lysosome abundance and size. Studies in cultured mammary epithelial cells revealed that while the involution signal TNFα promoted lysosome biogenesis and acidification, attenuation of ZnT2 impaired the lysosome response to this involution signal, which was not a consequence of cytoplasmic Zn accumulation. Our findings establish ZnT2 as a novel regulator of vacuolar ATPase assembly, driving lysosome biogenesis, acidification, and tissue remodeling during the initiation of mammary gland involution.
Comparison of folate-conjugated rapamycin versus unconjugated rapamycin in an orthologous mouse model of polycystic kidney disease
Authors: Kipp Kevin R. , Kruger Samantha L. , Schimmel Margaret F. , Parker Nikki , Shillingford Jonathan M. , Leamon Christopher P. , Weimbs Thomas
Published: May 2018

Autosomal-dominant polycystic kidney disease (ADPKD) is a very common genetic disease leading to renal failure. Numerous aberrantly regulated signaling pathways have been identified as promising molecular drug targets for ADPKD therapy. In rodent models, many small-molecule drugs against such targets have proven effective in reducing renal cyst growth. For example, mammalian target of rapamycin (mTOR) inhibition with rapamycin greatly ameliorates renal cystic disease in several rodent models. However, clinical trials with mTOR inhibitors were disappointing largely due to the intolerable extrarenal side effects during long-term treatment with these drugs. Most other potential drug targets in ADPKD are also widely expressed in extrarenal tissues, which makes it likely that untargeted therapies with small-molecule inhibitors against such targets will lead to systemic adverse effects during the necessary long-term treatment of years and decades in ADPKD patients. To overcome this problem, we previously demonstrated that folate-conjugated rapamycin (FC-rapa) targets polycystic kidneys due to the high expression of the folate receptor (FRα) and that treatment of a nonortholgous PKD mouse model leads to inhibition of renal cyst growth. Here we show, in a head-to-head comparison with unconjugated rapamycin, that FCrapa inhibits renal cyst growth, mTOR activation, cell cycling, and fibrosis in an orthologous Pkd1 mouse model. Both unconjugated rapamycin and FC-rapa are similarly effective on polycystic kidneys in this model. However, FC-rapa lacks the extrarenal effects of unconjugated rapamycin, in particular immunosuppressive effects. We conclude that folate-conjugation is a promising avenue for increasing the tissue specificity of small-molecule compounds to facilitate very long-term treatment in ADPKD.
Interspike interval analysis and spikelets in presubicular head-direction cells
Authors: Coletta Stefano , Zeraati Roxana , Nasr Khaled , Preston-Ferrer Patricia , Burgalossi Andrea
Published: May 2018

Head-direction (HD) neurons are thought to provide the mammalian brain with an internal sense of direction. These cells, which selectively increase their firing when the animal’s head points in a specific direction, use the spike rate to encode HD with a high signal-to-noise ratio. In the present work, we analyzed spike train features of presubicular HD cells recorded juxtacellularly in passively rotated rats. We found that HD neurons could be classified into two groups on the basis of their propensity to fire spikes at short interspike intervals. “Bursty” neurons displayed distinct spike waveforms and were weakly but significantly more modulated by HD compared with “nonbursty” cells. In a subset of HD neurons, we observed the occurrence of spikelets, small-amplitude “spike-like” events, whose HD tuning was highly correlated to that of the co-recorded juxtacellular spikes. Bursty and nonbursty HD cells, as well as spikelets, were also observed in freely moving animals during natural behavior. We speculate that spike bursts and spikelets might contribute to presubicular HD coding by enhancing its accuracy and transmission reliability to downstream targets.

NEW & NOTEWORTHY We provide evidence that presubicular head-direction (HD) cells can be classified into two classes (bursty and nonbursty) on the basis of their propensity to fire spikes at short interspike intervals. Bursty cells displayed distinct electrophysiological properties and stronger directional tuning compared with nonbursty neurons. We also provide evidence for the occurrence of spikelets in a subset of HD cells. These electrophysiological features (spike bursts and spikelets) might contribute to the precision and robustness of the presubicular HD code.