bluuebunny/crossref_metadata_2025 huggingface dataset:
How Deep‐Level and Surface‐Level Board Diversity, Formal and Informal Social Structures Affect Innovation
Authors: Chen Guoli , Hsu Po‐Hsuan , Lee Yen Teik , Mack Daniel Z.
Published: February 2024

Despite a growing interest in understanding how board diversity shapes firms’ innovation, findings about the impact of board diversity have remained mixed. In this paper, we conceptualize board diversity as two forms – deep‐level and surface‐level – and find that these two forms of board diversity have opposing effects on a firm's innovation. We also theorize how formal and informal social structures can strengthen the positive effect of deep‐level diversity yet simultaneously weaken the negative impact of surface‐level diversity. We test our hypotheses with a panel of 42,432 firm‐year observations from 2000 to 2019. Our paper contributes to the literature on boards and innovation by highlighting and differentiating the mechanisms through which board diversity affects innovation, as well as showing how formal and informal structures can moderate the effects of board diversity.
The assembly line at Ford and transportation platforms: A historical comparison of labour process reorganisation
Authors: Hughes Carl
Published: February 2024

This paper provides a historical comparison of the introduction of the moving assembly line at Ford Motor factories in the early 20th century, with the development of transportation platforms in the 21st century. The paper pushes back against the argument that either of these cases was based upon technological innovation, arguing that in neither case was new technology developed, but rather existing machinery was made use of. The paper argues that each case was built upon the reorganisation of the labour process, to increase the control that capital held over the labour process, increase the intensity of work and increase the levels of exploitation and surplus value extraction that workers are subjected to. By demonstrating this, it removes the technological façade that contemporary platforms hide behind, showing that they do not represent a qualitative break from the past, but rather the repackaging of old forms of work intensification.
Effectiveness of dupilumab in pediatric patients with a nummular phenotype of atopic dermatitis
Authors: Kim Eun Jae , Hlobik Madeline , Ho Tina
Published: February 2024

The nummular phenotype of atopic dermatitis is clinically characterized by pruritic, coin‐shaped plaques that are frequently recalcitrant to treatment. In this study, a retrospective chart review was conducted to evaluate the effectiveness and safety of dupilumab in children with nummular lesions of dermatitis. Twelve out of 14 patients demonstrated significant clinical improvement at a median time of 2.5 months (interquartile range, 1–4) after dupilumab initiation. A single case of paradoxical psoriasiform eruption was the only side effect reported in our cohort.
Spaces of subsidiarity: A comparative inquiry into the social agenda of Cohesion Policy
Authors: Ballantyne Steven , Mascioli Lorenzo
Published: February 2024

Cohesion Policy—the European Union's (EU) policy platform for regional and local development—represents a major yet often neglected instance of Social Europe. In this article we inquire into the delivery of Cohesion Policy projects concerned with social policy objectives. Specifically, we ask: how are these projects delivered? Building on the literature of subsidiarisation in social policy, we theorise that the interaction of two processes—vertical subsidiarisation across territorial levels and horizontal subisidiarisation across sectoral levels—generates different spaces of subsidiarity, with major implications for policy outputs and outcomes. Empirically, we explore the emergence of spaces of subsidiarity in over 800 Cohesion Policy projects for quality employment and labour mobility delivered in Italy, Portugal, and Spain, during the 2010s. We show that, despite common rules, the governance framework through which the social agenda of Cohesion Policy is implemented is not a constant but a variable, one that may be leveraged by future research to explain the heterogeneous impact of Cohesion Policy across the EU. Our contribution is relevant to research on Social Europe, research on the territorial dimension of post‐industrial welfare systems as well as research on Cohesion Policy.
Effect of major trauma on the expected number of births in Finnish women: A nationwide population‐based public data and register analysis
Authors: Vaajala Matias , Kuitunen Ilari , Mattila Ville M. , Yazer Mark H.
Published: February 2024

Background

The effect of major trauma on subsequent fertility is poorly described. If women have lower fertility after trauma, they would have a lower risk of anti‐D mediated hemolytic disease of the fetus and newborn in a future pregnancy following the transfusion of RhD‐positive blood to RhD‐negative women during their resuscitation.

Study Design and Methods

Data was obtained from the Care Register for Health Care, National Medical Birth Register, and open access data from Statistic Finland to evaluate the effect of major trauma (traumatic brain injuries, spine, pelvic, hip/thigh fractures) on the age‐specific number of births during years 1998–2018. The total number of births before a specific maternal age for different trauma populations was calculated and these were compared to the corresponding number of births in the general population.

Results

There were 50,923 injured women in this study. All injured women, including when analyzed by the nature of their injury, demonstrated lower expected numbers of births starting at approximately 28 years of age compared to the general population of women in Finland. At age 49, the expected number of births in the general population was approximately 1.8, whereas for all injured women 0.6, women with TBIs and spine fractures 0.6, women with pelvic fractures 0.5, and women with hip or thigh fractures 0.3.

Discussion

Injured women are predicted to have lower fertility rates compared to the general population of Finnish women. The lower fertility rate should be considered when planning a blood product resuscitation strategy for injured women.
“¿Y cómo devolvemos lo aprendido?”: apropiación y racialización en la investigación musical en Colombia. Una aproximación desde sus contraimaginarios
Authors: Ciro-Gómez Bernardo A , Tenorio Quiñones Francisco Alexander , Rapalino Barrionuevo Héctor Enrique
Published: February 2024

Las manifestaciones músico-danzarias de tradición oral tienen una importante participación en la investigación musical en Colombia. No obstante, los actuales desencuentros entre “informantes” e “investigadores” demuestran que la disputa por esos saberes y conocimientos dejó de ser un asunto insustancial a pesar del poco interés manifestado por los estudios especializados. En el artículo reflexionamos a partir del devenir de algunas músicas de tradición oral y sus cultores, para develar la lógica de inferiorización que subyace a su reapropiación en el contexto de la investigación musical académica. A tal efecto, en la metodología confluyen elementos de revisión historiográfico- musical y observación participante que permiten concluir que esta lógica es una de las principales generadoras del aumento exponencial de las desigualdades entre comunidades musicales e investigadores. Consideramos que nuestra interpretación antropológico-ética de acontecimientos tan relevantes podría contribuir al debate sobre iniciativas investigativas en música más incluyentes.
Empujando los “límites del archivo”: ejercicios antirracistas de historia institucional entre ciencias sociales y arte
Authors: Bosa Bastien , Angulo Ramírez Diana Carolina
Published: February 2024

El artículo presenta una reflexión a partir de un proyecto de investigación que busca reconstruir la historia de la Universidad del Rosario en relación con la esclavización y otras formas de opresión racial. Inicialmente, el proyecto tenía como objetivo examinar críticamente la historia de la opresión racial a través de una exploración de los archivos disponibles en un intento por arrojar luz sobre las vidas de las personas esclavizadas que estaban asociadas con la Universidad y enfatizar su humanidad y lucha por la libertad. Sin embargo, con el tiempo se ampliaron los objetivos para incluir iniciativas de historia pública que promovieran un diálogo entre las ciencias sociales y el arte, desde un enfoque antipatriarcal, antirracista y decolonial. Además del proyecto de investigación, se presentan cuatro iniciativas memoriales asociadas con este. Estas iniciativas incluyen un recorrido físico y virtual, una exposición de retratos imaginados creados con la ayuda de la inteligencia artificial (IA), una obra de teatro y un proyecto de exposición con artistas afrodescendientes. Tales iniciativas buscan crear consciencia sobre el pasado colonial de la Universidad y empujar los límites del archivo mediante la incorporación del arte y la historia pública.
Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8
Authors: Jiang Shan , Lin Xi , Wu Lijie , Wang Ling , Wu Yiran , Xu Ziyi , Xu Fei
Published: February 2024

The human CC chemokine receptor 8 (CCR8) is an emerging therapeutic target for cancer immunotherapy and autoimmune diseases. Understanding the molecular recognition of CCR8, particularly with nonpeptide ligands, is valuable for drug development. Here, we report three cryo–electron microscopy structures of human CCR8 complexed with G
i
trimers in the ligand-free state or activated by nonpeptide agonists LMD-009 and ZK 756326. A conserved Y
1.39
Y
3.32
E
7.39
motif in the orthosteric binding pocket is shown to play a crucial role in the chemokine and nonpeptide ligand recognition. Structural and functional analyses indicate that the lack of conservation in Y114
3.33
and Y172
4.64
among the CC chemokine receptors could potentially contribute to the selectivity of the nonpeptide ligand binding to CCR8. These findings present the characterization of the molecular interaction between a nonpeptide agonist and a chemokine receptor, aiding the development of therapeutics targeting related diseases through a structure-based approach.
Promoting (and targeting) alternative expression
Authors: Pillai Asha
Published: February 2024

Lineage-specific effects of upstream promoters affect ST2 expression and effector function in T
H
1cells.
Bacterial diversity and resistome analysis of drinking water stored in cisterns from two First Nations communities in Manitoba, Canada
Authors: Murdock Anita , Bashar Sabrin , White Dawn , Uyaguari-Diaz Miguel , Farenhorst Annemieke , Kumar Ayush
Published: February 2024

The microbiological content of water is an ongoing concern in First Nations communities in Canada. Many communities lack water treatment plants and continue to be under drinking water advisories. However, lack of access to treatment plants is only a part of the problem as poor water distribution systems also contribute to the failure to provide safe drinking water. Here, we studied the microbial diversity and antibiotic resistome from water stored in cisterns from two First Nations communities in Manitoba, Canada. We found that the cistern water contained a high number of bacteria and showed the presence of diverse antimicrobial resistance genes. Interestingly, the bacterial diversity and antimicrobial resistance genes varied considerably from that of the untreated source water, indicating that the origin of contamination in the cistern water came from within the treatment plant or along the delivery route to the homes. Our study highlights the importance of proper maintenance of the water distribution system in addition to access to water treatment facilities to ensure a supply of safe water to First Nations communities in Canada.

IMPORTANCE

The work described addresses a critical issue in First Nations communities in Canada—the microbiological content of water. Many of these communities lack access to water treatment plants and frequently experience drinking water advisories. This study focused on the microbial diversity and antibiotic resistome in water stored in cisterns within two First Nations communities in Manitoba, Canada. These findings reveal that cistern water, a common source of drinking water in these communities, contains a high number of bacteria and a wide range of antimicrobial resistance genes. This highlights a serious health risk as exposure to such water can lead to the spread of drug-resistant infections, posing a threat to the well-being of the residents.
K isomers in atomic nuclei
Authors: Walker P. M. , Kondev F. G.
Published: February 2024

The properties ofKisomers are reviewed. Energies and decay hindrance factors are considered in detail for selected isomers in the$$A \approx $$A≈ 160–190 region, focusing on pairing effects and the keyK-mixing mechanisms that influence$$\gamma $$γ-ray decay rates. The$$\beta $$β-decay ofKisomers is studied, indicating that, far from the valley of$$\beta $$βstability, high-K$$\beta $$β-decaying isomers will populate high-Kstates in the daughter nuclei. The challenges of revealing predicted, but as-yet undiscovered, long-lived isomers in the neutron-rich$$N \approx 116$$N≈116prolate–oblate shape transition region are highlighted, and the occurrence of oblate high-Kisomers is discussed. The 2015 multi-quasiparticleK-isomer table of Kondev, Dracoulis, and Kibédi is updated.
A new exploration tool in the search for native hydrogen and helium
Authors: Olivares Carolina , Findlay Jennifer , Kelly Ranald , Otto Simon , Norman Max , Cairns Michael
Published: February 2024

Native hydrogen and helium have been considered important resources in assisting the energy transition. Hydrogen and helium seeps have been reported worldwide, which may indicate large reserves within the subsurface. However, generation of hydrogen and helium is complex; poorly understood and constrained for both generation processes and migration. One source of native hydrogen is ultramafic rocks, which have experienced serpentinization together with water radiolysis. In contrast, helium generation occurs as the result of the radioactive decay of uranium and thorium present within radiogenically enriched basement. An exploration tool, dedicated to identifying areas with the geological settings and conditions favourable for native hydrogen and helium generation, has been developed and tested. Several databases have been created and integrated as part of this study (geological and geochemical generation models) to support and focus the search for both hydrogen and helium. Machine learning algorithms which extract value from geospatial data types for detecting various accumulations have been implemented. The first machine learning results demonstrate the significant value in integrating data and machine learning for high grading areas more conducive to accumulating hydrogen and helium.
“HOT” ChatGPT: The Promise of ChatGPT in Detecting and Discriminating Hateful, Offensive, and Toxic Comments on Social Media
Authors: Li Lingyao , Fan Lizhou , Atreja Shubham , Hemphill Libby
Published: February 2024

Harmful textual content is pervasive on social media, poisoning online communities and negatively impacting participation. A common approach to this issue is developing detection models that rely on human annotations. However, the tasks required to build such models expose annotators to harmful and offensive content and may require significant time and cost to complete. Generative AI models have the potential to understand and detect harmful textual content. We used ChatGPT to investigate this potential and compared its performance with MTurker annotations for three frequently discussed concepts related to harmful textual content on social media: Hateful, Offensive, and Toxic (HOT). We designed five prompts to interact with ChatGPT and conducted four experiments eliciting HOT classifications. Our results show that ChatGPT can achieve an accuracy of approximately 80% when compared to MTurker annotations. Specifically, the model displays a more consistent classification for non-HOT comments than HOT comments compared to human annotations. Our findings also suggest that ChatGPT classifications align with the provided HOT definitions. However, ChatGPT classifies “hateful” and “offensive” as subsets of “toxic.” Moreover, the choice of prompts used to interact with ChatGPT impacts its performance. Based on these insights, our study provides several meaningful implications for employing ChatGPT to detect HOT content, particularly regarding the reliability and consistency of its performance, its understanding and reasoning of the HOT concept, and the impact of prompts on its performance. Overall, our study provides guidance on the potential of using generative AI models for moderating large volumes of user-generated textual content on social media.
Upscaling of Reactive Mass Transport through Porous Electrodes in Aqueous Flow Batteries
Authors: Wlodarczyk Jakub K. , Schärer Roman P. , Friedrich K. Andreas , Schumacher Jürgen O.
Published: February 2024

Porous electrodes (PEs) are an important component of modern energy storage devices, such as lithium-ion batteries, flow batteries or fuel cells. Their complicated multiphase structure presents a considerable challenge to modeling and simulation. In this paper, we apply the volume-averaging method (VAM) as an efficient approach for the evaluation of effective macroscopic transport parameters in PEs. We consider the transport of electro-active species coupled to heterogeneous Butler-Volmer type reactions at the electrode surface. We identify the characteristic scales and dimensionless groups for the application to aqueous flow batteries. We validate the VAM-based model with direct numerical simulation results and literature data showing excellent agreement. Subsequently, we characterize several simplified periodic PE structures in 2D and 3D in terms of hydraulic permeability, effective dispersion and the effective kinetic number. We apply the up-scaled transport parameters to a simple macroscopic porous electrode to compare the overall efficiency of different pore-scale structures and material porosity values over a wide range of energy dissipation values. This study also reveals that the Bruggeman correction, commonly used in macroscopic porous electrode models, becomes inaccurate for realistic kinetic numbers in flow battery applications and should be used with care.
Thick Branes in Horndeski Gravity
Authors: Santos Fabiano F. , Brito F. A.
Published: February 2024

We investigate thick brane solutions in the Horndeski gravity. In this setup, we found analytical solutions, applying the first-order formalism to two scalar fields where the first field comes from the nonminimal scalar-tensor coupling and the second is due to the matter contribution sector. With these analytical solutions, we evaluate the symmetric thick brane solutions in Horndeski gravity with four-dimensional geometry. In such a setup, we evaluate the gravity fluctuations to find “almost massless modes,” for any values of the Horndeski parameters. These modes were used to compute the corrections to the Newtonian potential and evaluate the limit four-dimensional gravity.
Supplemental Table 3 from Acceptability of Personalized Lung Cancer Screening Program Among Primary Care Providers
Authors: Resong Paul J. , Niu Jiangong , Duhon Gabrielle F. , Foxhall Lewis E. , Shete Sanjay , Volk Robert J. , Toumazis Iakovos
Published: February 2024

Supplemental Table 3 shows a logistic regression analysis investigating various provider characteristics (age, gender, race, profession, years in practice, patients per week, work in a residency training site, work setting) as they influence responses to the question of whether or not providers consider increased time requirement as a barrier to personalized lung cancer screening implementation.
Supplemental Table 1 from Acceptability of Personalized Lung Cancer Screening Program Among Primary Care Providers
Authors: Resong Paul J. , Niu Jiangong , Duhon Gabrielle F. , Foxhall Lewis E. , Shete Sanjay , Volk Robert J. , Toumazis Iakovos
Published: February 2024

Supplemental Table 1. Respondent demographics
Supplementary Table S6 from High-Fat Diet Promotes Acute Promyelocytic Leukemia through PPARδ-Enhanced Self-renewal of Preleukemic Progenitors
Authors: Mazzarella Luca , Falvo Paolo , Adinolfi Marta , Tini Giulia , Gatti Elena , Piccioni Rossana , Bonetti Emanuele , Gavilán Elena , Valli Debora , Gruszka Alicja , Bodini Margherita , Gallo Barbara , Orecchioni Stefania , de Michele Giulia , Migliaccio Enrica , Duso Bruno A. , Roerink Sophie , Stratton Mike , Bertolini Francesco , Alcalay Myriam , Dellino Gaetano Ivan , Pelicci Pier Giuseppe
Published: February 2024

Supplementary Table S6: KEGG enrichR analysis in LINO vs BSA treatment in NB4 cxll RNAseq
Supplementary Table S3 from High-Fat Diet Promotes Acute Promyelocytic Leukemia through PPARδ-Enhanced Self-renewal of Preleukemic Progenitors
Authors: Mazzarella Luca , Falvo Paolo , Adinolfi Marta , Tini Giulia , Gatti Elena , Piccioni Rossana , Bonetti Emanuele , Gavilán Elena , Valli Debora , Gruszka Alicja , Bodini Margherita , Gallo Barbara , Orecchioni Stefania , de Michele Giulia , Migliaccio Enrica , Duso Bruno A. , Roerink Sophie , Stratton Mike , Bertolini Francesco , Alcalay Myriam , Dellino Gaetano Ivan , Pelicci Pier Giuseppe
Published: February 2024

Supplementary Table S3: VEP analysis of mutations in APL WES and colonies WGS
Supplementary Figure S6 from RALDH1 Inhibition Shows Immunotherapeutic Efficacy in Hepatocellular Carcinoma
Authors: Yu Pengfei , Cao Shuwen , Yang Shyh-Ming , Rai Ganesha , Martinez Natalia J. , Yasgar Adam , Zakharov Alexey V. , Simeonov Anton , Molina Arocho William A. , Lobel Graham P. , Mohei Hesham , Scott Alexis L. , Zhai Li , Furth Emma E. , Simon M. Celeste , Haldar Malay
Published: February 2024

Supplementary Figure
Supplementary Tables from M9657 Is a Bispecific Tumor-Targeted Anti-CD137 Agonist That Induces MSLN-Dependent Antitumor Immunity without Liver Inflammation
Authors: Xu Chunxiao , Zhou Xueyuan , Webb Lindsay , Yalavarthi Sireesha , Zheng Wenxin , Saha Somdutta , Schweickhardt Rene , Soloviev Maria , Jenkins Molly H. , Brandstetter Susanne , Belousova Natalya , Alimzhanov Marat , Rabinovich Brian , Deshpande Amit M. , Brewis Neil , Helming Laura
Published: February 2024

Supplementary Tables S1-S9
Figure S8 from M9657 Is a Bispecific Tumor-Targeted Anti-CD137 Agonist That Induces MSLN-Dependent Antitumor Immunity without Liver Inflammation
Authors: Xu Chunxiao , Zhou Xueyuan , Webb Lindsay , Yalavarthi Sireesha , Zheng Wenxin , Saha Somdutta , Schweickhardt Rene , Soloviev Maria , Jenkins Molly H. , Brandstetter Susanne , Belousova Natalya , Alimzhanov Marat , Rabinovich Brian , Deshpande Amit M. , Brewis Neil , Helming Laura
Published: February 2024

FS122m surrogate and M9657 chimeric antibodies display significant antitumor efficacy in syngeneic models
Figure S2 from M9657 Is a Bispecific Tumor-Targeted Anti-CD137 Agonist That Induces MSLN-Dependent Antitumor Immunity without Liver Inflammation
Authors: Xu Chunxiao , Zhou Xueyuan , Webb Lindsay , Yalavarthi Sireesha , Zheng Wenxin , Saha Somdutta , Schweickhardt Rene , Soloviev Maria , Jenkins Molly H. , Brandstetter Susanne , Belousova Natalya , Alimzhanov Marat , Rabinovich Brian , Deshpande Amit M. , Brewis Neil , Helming Laura
Published: February 2024

M9657 is not appreciably internalized in MSLN+ cells
Figure S11 from M9657 Is a Bispecific Tumor-Targeted Anti-CD137 Agonist That Induces MSLN-Dependent Antitumor Immunity without Liver Inflammation
Authors: Xu Chunxiao , Zhou Xueyuan , Webb Lindsay , Yalavarthi Sireesha , Zheng Wenxin , Saha Somdutta , Schweickhardt Rene , Soloviev Maria , Jenkins Molly H. , Brandstetter Susanne , Belousova Natalya , Alimzhanov Marat , Rabinovich Brian , Deshpande Amit M. , Brewis Neil , Helming Laura
Published: February 2024

FS122m increases infiltration of CD8+ T cells but not other immune subsets in the TME and spleen of the CT26-KSA tumor model
Supplement figure 6 from Tumor-Derived RAB21+ABHD12+ sEVs Drive the Premetastatic Microenvironment in the Lung
Authors: Wu Kun , Li Yan , Ji Yikang , Liu Chun , Wang Xiaoning , Guo Haiyan , Zhang Jianjun , He Yue
Published: February 2024

Supplementary Figure 6. The upregulated S1PR1 was mediated by FoxO signaling pathway. (a) Volcano plot showing the differential expressed genes of macrophages with ABHD12-OE; (b-c) The sEVs (50 μg) derived from HNSCC cell lines were cocultured with macrophages (1 × 106) for 24 h. (b) Immunoblotting analysis for S1PR1 in macrophages cocultured with sEVs. (c) Quantitative analysis for S1PR1 in macrophages cocultured with sEVs. (d) GSEA analysis of up-stream events of FoxO regulation in macrophages with ABHD12-OE; (e-h) Quantitative analysis for AKT and FoxO1 phosphorylation in macrophages (ABHD12-OE and ABHD12-KD) following treatment with AKT inhibitor (MK-2206) or agonist (SC79). (i) The percentage of M2 macrophages after macrophages with ABHD12-KD or ABHD12-OE treated with an AKT inhibitor or agonist.
Supplementary Figure 6 from Immune Modulation of Innate and Adaptive Responses Restores Immune Surveillance and Establishes Antitumor Immunologic Memory
Authors: Alvero Ayesha B. , Fox Alexandra , Madina Bhaskara Reddy , Krady Marie M. , Gogoi Radhika , Chehade Hussein , Nakaar Valerian , Almassian Bijan , Yarovinsky Timur O. , Rutherford Thomas , Mor Gil
Published: February 2024

A. Kaplan Meier curve comparing overall survival in mice treated with PBS Control, CARG-2020, VLV-IL-12, VLV-17R ECD, VLV-shRNA PD-L1, and VLV-GFP; p<0.0001.
B. CARG-2020 but not VLV-IL-12 modulates the innate immune system. Peritoneal lavage from VLV-IL-12 and CARG-2020-treated mice (n=6) were analyzed by flow cytometry for macrophages using CD11b and CD206. VLV-IL-12 treatment is not able to increase the number of CD11blow/CD206- macrophages compared to CARG2020. Representative dot plots shown. Gating strategy is shown in Supp. Fig. 1.
C. Decrease on Ly6C+/Ly6G+ MSC is observed only in the CARG2020 treated group but not in those treated with VLV-IL-12 group. Representative dot plots shown. Gating strategy is shown in Supp. Fig. 1.
Supplementary Figure 4 from Immune Modulation of Innate and Adaptive Responses Restores Immune Surveillance and Establishes Antitumor Immunologic Memory
Authors: Alvero Ayesha B. , Fox Alexandra , Madina Bhaskara Reddy , Krady Marie M. , Gogoi Radhika , Chehade Hussein , Nakaar Valerian , Almassian Bijan , Yarovinsky Timur O. , Rutherford Thomas , Mor Gil
Published: February 2024

A. TKO mouse ovarian cancer cells were treated with increasing concentrations of CARG-2020 or VLV-GFP and effect on cell growth and cell death is quantified in real time using Cytation5/Biospa by measuring mCherry confluence and CelltoxTM fluorescence; B. Representative fluorescence images showing PBS Control and CARG-2020-treated cultures. red, mCherry; green, CelltoxTM; C. Human ovarian cancer cells, clone OCSC1-F2 and the hTERT-immortalized human endometrial stromal cells were treated with increasing concentrations of CARG-2020 for 72h and cell death was quantified using CelltoxTM fluorescence. Note that CARG-2020 induces cell death only in cancer cells and not in normal cells.
Supplementary Table S1 from Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages
Authors: Manara Maria Cristina , Manferdini Cristina , Cristalli Camilla , Carrabotta Marianna , Santi Spartaco , De Feo Alessandra , Caldoni Giulia , Pasello Michela , Landuzzi Lorena , Lollini Pier-Luigi , Salamanna Francesca , Dominici Sabrina , Fiori Valentina , Magnani Mauro , Lisignoli Gina , Scotlandi Katia
Published: February 2024

Oligonucleotide primer sequences
Supplementary Figure 6 from Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages
Authors: Manara Maria Cristina , Manferdini Cristina , Cristalli Camilla , Carrabotta Marianna , Santi Spartaco , De Feo Alessandra , Caldoni Giulia , Pasello Michela , Landuzzi Lorena , Lollini Pier-Luigi , Salamanna Francesca , Dominici Sabrina , Fiori Valentina , Magnani Mauro , Lisignoli Gina , Scotlandi Katia
Published: February 2024

Supplementary Figure 6
Supplementary Figure 3 from Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages
Authors: Manara Maria Cristina , Manferdini Cristina , Cristalli Camilla , Carrabotta Marianna , Santi Spartaco , De Feo Alessandra , Caldoni Giulia , Pasello Michela , Landuzzi Lorena , Lollini Pier-Luigi , Salamanna Francesca , Dominici Sabrina , Fiori Valentina , Magnani Mauro , Lisignoli Gina , Scotlandi Katia
Published: February 2024

Supplementary Figure 3
Data from Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages
Authors: Manara Maria Cristina , Manferdini Cristina , Cristalli Camilla , Carrabotta Marianna , Santi Spartaco , De Feo Alessandra , Caldoni Giulia , Pasello Michela , Landuzzi Lorena , Lollini Pier-Luigi , Salamanna Francesca , Dominici Sabrina , Fiori Valentina , Magnani Mauro , Lisignoli Gina , Scotlandi Katia
Published: February 2024

Abstract
Ewing sarcoma (EWS) is the second most common pediatric bone tumor. The EWS tumor microenvironment is largely recognized as immune-cold, with macrophages being the most abundant immune cells and their presence associated with worse patient prognosis. Expression of CD99 is a hallmark of EWS cells, and its targeting induces inhibition of EWS tumor growth through a poorly understood mechanism. In this study, we analyzed CD99 expression and functions on macrophages and investigated whether the concomitant targeting of CD99 on both tumor and macrophages could explain the inhibitory effect of this approach against EWS. Targeting CD99 on EWS cells downregulated expression of the “don't eat-me” CD47 molecule but increased levels of the “eat-me” phosphatidyl serine and calreticulin molecules on the outer leaflet of the tumor cell membrane, triggering phagocytosis and digestion of EWS cells by macrophages. In addition, CD99 ligation induced reprogramming of undifferentiated M0 macrophages and M2-like macrophages toward the inflammatory M1-like phenotype. These events resulted in the inhibition of EWS tumor growth. Thus, this study reveals what we believe to be a previously unrecognized function of CD99, which engenders a virtuous circle that delivers intrinsic cell death signals to EWS cells, favors tumor cell phagocytosis by macrophages, and promotes the expression of various molecules and cytokines, which are pro-inflammatory and usually associated with tumor regression. This raises the possibility that CD99 may be involved in boosting the antitumor activity of macrophages.
Supplementary Figure S2 from Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer
Authors: Suda Kazuto , Okabe Atsushi , Matsuo Junichi , Chuang Linda Shyue Huey , Li Ying , Jangphattananont Nawaphat , Mon Naing Naing , Myint Khine Nyein , Yamamura Akihiro , So Jimmy Bok-Yan , Voon Dominic Chih-Cheng , Yang Henry , Yeoh Khay Guan , Kaneda Atsushi , Ito Yoshiaki
Published: February 2024

RUNX3 promotes cancer cell migration, invasion and anchorage independent growth in gastric cancer cells A, RT-qPCR analysis for RUNX3 mRNA in HGC-27 after RUNX3 KO; ****, P < 0.0001 by a twotailed Student t test. B, immunoblot shows absence of RUNX3 protein in HGC-27 by CRISPR/Cas9 mediated KO. C, WST-1 cell proliferation assay in HGC-27 after RUNX3 KO; **, P < 0.01 by a two-tailed Student t test. D, invasion and migration analysis for HGC-27 after RUNX3 KO. Experiments were repeated three times. Typical images from one experiment are shown. E, cell invasion and migration were counted and quantified from 5 different high-power fields in each experiment; ***, P < 0.001 by a two-tailed Student t test. F, immunoblot shows overexpression (OE) of RUNX3 protein in HGC-27 RUNX3 KO cells. G, invasion and migration analysis for HGC-27 RUNX3 KO cells after RUNX3 OE. Experiments were repeated three times. Typical images from one experiment are shown. H, cell invasion and migration were counted and quantified from 5 different high-power fields in each experiment; **, P < 0.01 and *, P < 0.05 by a two-tailed Student t test. I, representative images for HGC-27 after RUNX3 KO in soft agar colony formation assay. J, the number of colony formation was counted and shown as a fold change to control cells (mean + SD); **, P < 0.01 by a two-tailed Student t test.
Supplementary Data S1 from Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer
Authors: Suda Kazuto , Okabe Atsushi , Matsuo Junichi , Chuang Linda Shyue Huey , Li Ying , Jangphattananont Nawaphat , Mon Naing Naing , Myint Khine Nyein , Yamamura Akihiro , So Jimmy Bok-Yan , Voon Dominic Chih-Cheng , Yang Henry , Yeoh Khay Guan , Kaneda Atsushi , Ito Yoshiaki
Published: February 2024

The excel file shows active RUNX3 binding sites enriched with CDX2, LHX2 and TCF3 motifs and their corresponding GO biological processes at the Pages 1, 2 and 3, respectively.
FIGURE 6 from Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer
Authors: Suda Kazuto , Okabe Atsushi , Matsuo Junichi , Chuang Linda Shyue Huey , Li Ying , Jangphattananont Nawaphat , Mon Naing Naing , Myint Khine Nyein , Yamamura Akihiro , So Jimmy Bok-Yan , Voon Dominic Chih-Cheng , Yang Henry , Yeoh Khay Guan , Kaneda Atsushi , Ito Yoshiaki
Published: February 2024

Direct WNT5A activation by RUNX3 would be a therapeutic strategy in gastric cancer. A and B, Representative imaging of immunofluorescence study in gastric cancer specimens (n = 35). A case showing high expression for RUNX3 (red) and WNT5A (green) in Ecadherin positive (blue) cancer cells (A) and a case showing negative RUNX3 and WNT5A expression in E-cadherin positive cancer cells (B) are shown. Arrows indicate the absence of RUNX3 and WNT5A in E-cadherin regions. Dotted boxes indicate enlarged regions. Scale bar: 50 µm. C, Positive correlation between RUNX3 and WNT5A expression in E-cadherin positive cancer cells by immunofluorescence study is indicated statistically (n = 35, Pearson; r = 0.4744, P < 0.01, Spearman; r = 0.3622, P < 0.05).
FIGURE 4 from Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer
Authors: Suda Kazuto , Okabe Atsushi , Matsuo Junichi , Chuang Linda Shyue Huey , Li Ying , Jangphattananont Nawaphat , Mon Naing Naing , Myint Khine Nyein , Yamamura Akihiro , So Jimmy Bok-Yan , Voon Dominic Chih-Cheng , Yang Henry , Yeoh Khay Guan , Kaneda Atsushi , Ito Yoshiaki
Published: February 2024

Histone modification and interactions proximal to genes transcriptionally activated by RUNX3. ChIP-seq analyses of histone modification and RUNX3 binding sites in HGC-27 control (cont) and RUNX3 KO cells are juxtaposed to H3K27ac HiChIP analyses. The representative genes include CD44, IGFBP3, VIM, WNT5A, DPYSL3, and RUNX2, based on the list of genes that showed high scores of P values and H3K27ac HiChIP profiles. Enhancer–promoter interactions are indicated by loops. Arrowhead indicates change in H3K27ac peak after RUNX3 KO.
FIGURE 3 from Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer
Authors: Suda Kazuto , Okabe Atsushi , Matsuo Junichi , Chuang Linda Shyue Huey , Li Ying , Jangphattananont Nawaphat , Mon Naing Naing , Myint Khine Nyein , Yamamura Akihiro , So Jimmy Bok-Yan , Voon Dominic Chih-Cheng , Yang Henry , Yeoh Khay Guan , Kaneda Atsushi , Ito Yoshiaki
Published: February 2024

RUNX3 drives a metastatic transcriptional program. A, A volcano plot obtained from RNA-seq. A total of 1,005 genes significantly downregulated (P < 0.05) in RUNX3 KO cells were identified, including CD44, Vimentin, IGFBP3, and WNT5A (marked in red). A total of 554 genes significantly upregulated (P < 0.05) in RUNX3 KO cells were identified, including GPNMB (marked in blue). All dots are visualized on the basis of expression alteration by ≥2-fold change by RUNX3 KO. B, Analysis of enriched pathway obtained from MSIgDB Hallmark 2020 and Gene Ontology Biological Process of significantly downregulated genes in RUNX3 KO cells (n = 1,005). C, Heat maps representing read densities of RUNX3, H3K27ac, H3K4me3 (promoter mark), and H3K4me1 (enhancer mark) in ±5-kb regions centered on RUNX3 binding sites. RUNX3 binding sites were classified into 642 sites around TSS and 2,492 distal to TSS (left). Enriched de novo motifs at the 642 RUNX3 binding site around TSS and the 2,492 distal regulatory regions are presented (right). D, Diagrams of H3K27ac HiChIP loops for prediction of RUNX3 target genes. Significant interactions were calculated (P < 0.05) in 10-kb (left) and 25-kb resolution (right). In 10-kb resolution, 2,301 loops between TSS's, 4,768 loops between TSS and distal region and 5,569 loops between distal regions were found using H3K27ac HiChIP data. Of them, 827 loops containing RUNX3 binding sites in distal region were identified. In 25-kb resolution, 6,734 loops between TSS's, 13,092 loops between TSS and distal region, 12,466 loops between distal regions were found using H3K27ac HiChIP data. Of them, 2,357 loops containing RUNX3 binding sites in distal region were identified. E, Rate of differentially expressed genes in among the RUNX3 target genes predicted by H3K27ac HiChIP. A total of 178 and 58 genes were significantly downregulated and upregulated, respectively, by RUNX3 KO. F, Enriched pathways obtained from MSIgDB Hallmark 2020 2 and Gene Ontology Biological Process, analyzing significantly repressed RUNX3 target genes in RUNX3 KO cells.
Cultural Adaptation of Recipes
Authors: Cao Yong , Kementchedjhieva Yova , Cui Ruixiang , Karamolegkou Antonia , Zhou Li , Dare Megan , Donatelli Lucia , Hershcovich Daniel
Published: February 2024

Building upon the considerable advances in Large Language Models (LLMs), we are now equipped to address more sophisticated tasks demanding a nuanced understanding of cross-cultural contexts. A key example is recipe adaptation, which goes beyond simple translation to include a grasp of ingredients, culinary techniques, and dietary preferences specific to a given culture. We introduce a new task involving the translation and cultural adaptation of recipes between Chinese- and English-speaking cuisines. To support this investigation, we present CulturalRecipes, a unique dataset composed of automatically paired recipes written in Mandarin Chinese and English. This dataset is further enriched with a human-written and curated test set. In this intricate task of cross-cultural recipe adaptation, we evaluate the performance of various methods, including GPT-4 and other LLMs, traditional machine translation, and information retrieval techniques. Our comprehensive analysis includes both automatic and human evaluation metrics. While GPT-4 exhibits impressive abilities in adapting Chinese recipes into English, it still lags behind human expertise when translating English recipes into Chinese. This underscores the multifaceted nature of cultural adaptations. We anticipate that these insights will significantly contribute to future research on culturally aware language models and their practical application in culturally diverse contexts.
Metric-Free Learning Network with Dual Relations Propagation for Few-Shot Aspect Category Sentiment Analysis
Authors: Zhao Shiman , Xie Yutao , Chen Wei , Wang Tengjiao , Yao Jiahui , Zheng Jiabin
Published: February 2024

Few-shot Aspect Category Sentiment Analysis (ACSA) is a crucial task for aspect-based sentiment analysis, which aims to detect sentiment polarity for a given aspect category in a sentence with limited data. However, few-shot learning methods focus on distance metrics between the query and support sets to classify queries, heavily relying on aspect distributions in the embedding space. Thus, they suffer from overlapping distributions of aspect embeddings caused by irrelevant sentiment noise among sentences with multiple sentiment aspects, leading to misclassifications. To solve the above issues, we propose a metric-free method for few-shot ACSA, which models the associated relations among the aspects of support and query sentences by Dual Relations Propagation (DRP), addressing the passive effect of overlapping distributions. Specifically, DRP uses the dual relations (similarity and diversity) among the aspects of support and query sentences to explore intra-cluster commonality and inter-cluster uniqueness for alleviating sentiment noise and enhancing aspect features. Additionally, the dual relations are transformed from support-query to class-query to promote query inference by learning class knowledge. Experiments show that we achieve convincing performance on few-shot ACSA, especially an average improvement of 2.93% accuracy and 2.10% F1 score in the 3-way 1-shot setting.
Defining “Crisis” in Migration Governance: a Critical Legal Mapping of EU Crisis Response Mechanisms
Authors: Campesi Giuseppe
Published: February 2024

Over the past ten years, the language of crisis has become increasingly common in discourse about migration governance at the European Union (EU) level, and policy responses have been oriented by an emergency rationale that prioritizes short-term solutions over long-term planning. EU migration and asylum law incorporates several crisis response mechanisms, and the addition of a new set of instruments has recently been proposed. This paper offers a critical legal mapping of what counts as a “crisis” in EU migration and asylum law, and the mechanisms for responding to such crises. It exemplifies a complex system in which the tension between the imperative to address threats purportedly arising from unwanted migration is intricately intertwined with the necessity of granting Member States flexibility to respond to contingencies without compromising the integrity of the common EU asylum and migration system.
Uncertain buckling characteristics of thermally loaded and internally defected variable fiber spacing composite laminates
Authors: Chandrakar Prateek , Sharma Narayan , Maiti Dipak Kumar
Published: February 2024

The present investigation underscores the efficacy of laminated plates with variable fiber spacing (VFS) in the context of internal defects. The study involves the evaluation of the variability in buckling strength when faced with multiple tiers of damage; this is achieved through the implementation of an improved first-order shear deformation theory (IFSDT) within a finite element (FE) framework. Various types of fiber distribution (DT) are being examined to evaluate the effects of damage situated at both corner and mid locations. The application of a radial basis function network (RBFN)-based surrogate model demonstrates its potential as a feasible alternative to the computationally demanding Monte-Carlo simulations (MCS) for investigating the stochastic nature of buckling; the developed surrogate model requires reduced input sampling data to quantify buckling uncertainty. This study examines the stochastic nature of different material characteristics and observed that the uncertainty in the buckling response decreases with the increased damage severity. The assessment of the probability of failure is conducted subsequently. Following this, the damage ratios are influenced by randomness, leading to the pattern that an increased damage ratio corresponds to a more pronounced deviation in buckling uncertainty.
“We Know It's a Library”: Black Space, Black Women's Labor, and Radical Black Joy
Authors: Dunn Damaris C. , Tubman Kadiatou
Published: February 2024

The Junior Scholars Program (JSP) is a tuition-free youth learning program at the Schomburg Center for Research in Black Culture in Harlem, New York. At JSP, Damaris, a former JSP instructor, was introduced to Kadiatou, the Schomburg Center's former education and outreach programs manager. They write collaboratively to (re)member the dialectical relationship between Black women's labor, Black Space, and Radical Black Joy.
Improving the effectiveness of CPR during interventional procedures
Authors: Gaisendrees Christopher , Eghbalzadeh Kaveh , Adam Matti , Djordjevic Ilija , Mehler Oliver , Wahlers Thorsten , Kuhn Elmar W
Published: February 2024

Introduction

The number of interventional procedures, such as transcatheter aortic valve replacements or thoracic endovascular aortic repairs, is on the rise. Intraprocedural cardiac arrest is a rare occurrence during high-risk procedures. Modern hybrid-operating tables may adversely affect chest compression quality due to their flexibility. To investigate this relationship, we analyzed the blood pressure generated during chest compressions at different degrees of table extension and assessed the effect of an additional stabilization bar to secure the table.

Methods

A CPR manikin was connected to online blood pressure monitoring on a hybrid operating table. Chest compressions were administered using a mechanical device (at 100 bpm and 80 bpm). Hemodynamic effects were evaluated at various degrees of table extension (0%, 50%, 100% table extension) and with the addition of a stabilization bar.

Results

A greater degree of table extension was associated with lower diastolic blood pressure. The addition of a stabilization bar alleviated this drop in diastolic blood pressure and enabled the generation of higher mean arterial pressures at 50% and 100% table extension during chest compressions.

Conclusion

The flexibility of a hybrid operating table adversely impacts the hemodynamic effect of chest compressions. This effect may be mitigated by using a stabilization bar. These results may be relevant for providing further recommendations for CPR guidelines in hybrid OR settings.
‘We Must be Focused and We Must Organise’: Gender, Conflict and Human Rights Activism in Balochistan
Authors: Eggert Jennifer Philippa , Kanwer Maryam , Baloch Sadia
Published: February 2024

Although often overlooked and underestimated in official accounts, female activists play an important role in human rights and liberation movements worldwide. While women’s roles and experiences in the struggle for rights and liberation worldwide have been discussed in numerous publications, there is a lack of academic literature on the roles of women in the Baloch movement in Pakistan. Using a collaborative autoethnographic, dialogic approach, this article, which is based on a conversation between three researchers, practitioners and activists from Balochistan, other parts of Pakistan, and Europe, explores the motivations and experiences of women defending the human rights of the Baloch people in Pakistan, as well as possibilities for various types of solidarities (based on international, feminist, Muslim and interethnic alliances) in Pakistan and beyond. It shows how gender, age, ethnicity, class and location impact female activists’ experiences of activism, and outlines challenges and opportunities when it comes to building national and international alliances in support of the movement for Baloch rights in Pakistan.