bluuebunny/crossref_metadata_2025 huggingface dataset:
High-quality GaSb epitaxially grown on Si (001) through defects self-annihilation for CMOS-compatible near-IR light emitters
Authors: Tang Tianyi , Zhan Wenkang , Shen Chao , Li Manyang , Xu Bo , Wang Zhanguo , Zhao Chao
Published: December 2022

Direct epitaxial growth of III-V materials on complementary metal-oxide-semiconductor (CMOS)-compatible Si substrates has long been a scientific and engineering problem for next-generation light-emitters and non-volatile memories etc. The challenges arise from the lattice mismatch, thermal mismatch, and polarity mismatch between these materials. We report a detailed study of growing high-quality GaSb epilayers with low defect density on on-axis silicon substrates by interface engineering through all-molecular beam epitaxy (MBE) technology. We also systematically investigated the defect self-annihilation mechanism of GaSb epitaxially grown on on-axis Si (001) substrates. It was found that the misfit dislocation array was formed at the interface of AlSb/Si; threading dislocations and antiphase domain boundary annihilated at the initial GaSb layer promoted by the high-density AlSb islands, which was confirmed by transmission electron microscopy (TEM) results. Finally, a 2 µm GaSb epilayer with a step-flow surface, root-mean-square (RMS) roughness of 0.69 nm, and a rocking curve full width at half maximum (FWHM) of 251 arcsec was obtained. The photoluminescence in the near-infrared region of the GaSb/AlGaSb quantum well grown on Si substrate was also demonstrated. Our results highlighted the possible step towards the all-MBE direct growth of Sb-based infrared optoelectronic and microelectronic devices on CMOS-compatible Si substrates.
Early enforcement of cell identity by a functional component of the terminally differentiated state
Authors: Bahrami-Nejad Zahra , Zhang Zhi-Bo , Tholen Stefan , Sharma Sanjeev , Rabiee Atefeh , Zhao Michael L. , Kraemer Fredric B. , Teruel Mary N.
Published: December 2022

How progenitor cells can attain a distinct differentiated cell identity is a challenging problem given the fluctuating signaling environment in which cells exist and that critical transcription factors are often not unique to a differentiation process. Here, we test the hypothesis that a unique differentiated cell identity can result from a core component of the differentiated state doubling up as a signaling protein that also drives differentiation. Using live single-cell imaging in the adipocyte differentiation system, we show that progenitor fat cells (preadipocytes) can only commit to terminally differentiate after up-regulating FABP4, a lipid buffer that is highly enriched in mature adipocytes. Upon induction of adipogenesis in mouse preadipocyte cells, we show that after a long delay, cells first abruptly start to engage a positive feedback between CEBPA and PPARG before then engaging, after a second delay, a positive feedback between FABP4 and PPARG. These sequential positive feedbacks both need to engage in order to drive PPARG levels past the threshold for irreversible differentiation. In the last step before commitment, PPARG transcriptionally increases FABP4 expression while fatty acid-loaded FABP4 increases PPARG activity. Together, our study suggests a control principle for robust cell identity whereby a core component of the differentiated state also promotes differentiation from its own progenitor state.
A systematic review and global analysis of the seasonal activity of Phlebotomus (Paraphlebotomus) sergenti, the primary vectors of L. tropica
Authors: Karmaoui Ahmed , Sereno Denis , El Jaafari Samir , Hajji Lhoussain
Published: December 2022

Background

Phlebotomus (Paraphlebotomus) sergenti is a widespread proven vector of Leishmania pathogens causing anthroponotic cutaneous leishmaniasis (ACL), due to L. tropica, in the old world. The activity of P. (Par.) sergenti is seasonal and sensitive to general variations in climate. Phenological data sets can thus provide a baseline for continuing investigations on P. (Par.) sergenti population dynamics that may impact future leishmaniasis transmission and control scenarios.

Methods/Principal finding

A systematic review of the seasonality of P. (Par.) sergenti was undertaken globally. Six hundred eight scientific papers were identified, and data were extracted from 35 ones, with informative data on sand fly seasonal dynamics on trapping performed from 1992 to December 2021 on 63 sites from 12 countries. Morocco, Saudi Arabia, Iraq, Iran, Pakistan, Palestine, Turkey, Spain, Portugal, Italy, Cyprus, and Georgia. The data extracted from the literature survey were further normalized. Our analysis recorded that the highest P.(Par.) sergenti activity occurs during the hot and dry seasons, primarily in July and August, whatever the location studied. We noticed a relationship between the latitude of sites and sand fly presence (from early April to June) and the type of density trend, varying from a single peak to multiple peaks. On a geographical scale, P. (Par.) sergenti concentrates between 32–37° in latitude in a large interval following the longitude and the highest number of sites with high P. (Par.) sergenti activity is located at the latitude 32°. We also quoted a similar seasonal dynamic and geographic distribution with Phlebotomus (Phlebotomus) papatasi, a proven vector of L. major that causes cutaneous infection. No apparent risk for ACL occurred from December to March, at least in the years and geographic areas considered in this survey. Altogether, knowing that high P. (Par.) sergenti activity would be linked with an increased risk of leishmaniasis transmission, and our study provides information that can be used for control programs on ACL transmission.

Conclusions

Despite variations, we found a relatively homogeneous pattern of P. (Par.) sergenti potential behavior in sites whose data are published. A higher risk for L. tropica transmission was identified in the June-October period. Still, such risk was not equally distributed throughout the area since density waves of adults occurred earlier and were more frequent in some territories, like Saudi Arabia.
Quality criteria in MOOC: Comparative and proposed indicators
Authors: Ferreira Camino , Arias Ana R. , Vidal Javier
Published: December 2022

The MOOC (Massive Open Online Course) offer revolution requires processes that can define their quality, especially due to the number of courses offered, as well as the high number of students enrolled in them. The objective of this study is to identify the main requirements and indicators of the MOOC following the ENQA (The European Association for Quality Assurance in Higher Education) considerations. To establish this system, the study has been carried out through the Delphi method with successive rounds of application from the systematic use of expert judgment. This method has been applied to achieve consensus on a set of requirements and indicators of 20 experts from eight different institutions in the field of application and development of MOOCs that assessed the indicators according to the quality criteria according to three aspects: relevance, feasibility, and comparability. Therefore, the outcome of this study is a system as a mechanism for the university to approve or disapprove a MOOC (checklist) and assess its quality.
Prognosis of older patients with newly diagnosed AML undergoing antileukemic therapy: A systematic review
Authors: Hao Qiukui , Foroutan Farid , Han Mi Ah , Devji Tahira , Nampo Fernando Kenji , Mukherjee Sudipto , Alibhai Shabbir M. H. , Rosko Ashley , Sekeres Mikkael A. , Guyatt Gordon H. , Brignardello-Petersen Romina
Published: December 2022

Background and objective

The prognostic value of age and other non-hematological factors in predicting outcomes in older patients with newly diagnosed acute myeloid leukemia (AML) undergoing antileukemic therapy is not well understood. We performed a systematic review to determine the association between these factors and mortality and health-related quality of life or fatigue among these patients.

Methods

We searched Medline and Embase through October 2021 for studies in which researchers quantified the relationship between age, comorbidities, frailty, performance status, or functional status; and mortality and health-related quality of life or fatigue in older patients with AML receiving antileukemic therapy. We assessed the risk of bias of the included studies using the Quality in Prognostic Studies tool, conducted random-effects meta-analyses, and assessed the quality of the evidence using the Grading of Recommendations, Assessment, Development and Evaluation approach.

Results

We included 90 studies. Meta-analysis showed that age (per 5-year increase, HR 1.16 95% CI 1.11–1.21, high-quality evidence), comorbidities (Hematopoietic Cell Transplantation-specific Comorbidity Index: 3+ VS less than 3, HR 1.60 95% CI 1.31–1.95, high-quality evidence), and performance status (Eastern Cooperative Oncology Group/ World Health Organization (ECOG/WHO): 2+ VS less than 2, HR 1.63 95% CI 1.43–1.86, high-quality evidence; ECOG/WHO: 3+ VS less than 3, HR 2.00 95% CI 1.52–2.63, moderate-quality evidence) were associated with long-term mortality. These studies provided inconsistent and non-informative results on short-term mortality (within 90 days) and quality of life.

Conclusion

High-quality or moderate-quality evidence support that age, comorbidities, performance status predicts the long-term prognosis of older patients with AML undergoing antileukemic treatment.
TDLAS second harmonic demodulation based on Hilbert transform
Authors: Wu Junfeng , Chen Hanyu , Kang Guohua , Li Xu
Published: December 2022

A demodulation method for tunable diode laser absorption spectroscopy (TDLAS) second harmonic based on the Hilbert transform is proposed in this paper. The second harmonic of the TDLAS signal can be easily obtained without a reference signal. The TDLAS signal is firstly processed by band-pass filtering, then the envelope of the processed signal is obtained with Hilbert transform. And finally, the second harmonic is extracted from the 1f component of the envelope. The validity of the proposed method is confirmed by simulation and verified by experiment, and the result shows that the error is acceptable under the cases of weak absorbance, which indicates that the proposed method is applicable to practical trace gas detection.
Lumpy skin disease: A newly emerging disease in Southeast Asia
Authors: Ratyotha Kanokwan , Prakobwong Suksanti , Piratae Supawadee
Published: December 2022

Lumpy skin disease (LSD) is caused by LSD virus (LSDV). This virus has been classified in the genus Capripoxvirus, family Poxviridae which generally affects large ruminants, especially cattle and domestic water buffalo. The first outbreak of LSD was found in 1929 in Zambia, then spreading throughout Africa and with an ongoing expanding distribution to Asia and Europe. In 2020, LSD was found from Southeast Asia in Vietnam and Myanmar before reaching Thailand and Laos in 2021. Therefore, LSD is a newly emerging disease that occurs in Southeast Asia and needs more research about pathology, transmission, diagnosis, distribution, prevention, and control. The results from this review show the nature of LSD, distribution, and epidemic maps which are helpful for further information on the control and prevention of LSD.
Evaluation of a vaccine candidate isolated from Cryptosporidium parvum oocyst in mice
Authors: Aboelsoued Dina , Abdullah Hend H. A. M. , Abdel Megeed Kadria N. , Hassan Soad E. , Toaleb Nagwa I.
Published: December 2022

Background and Aim: Cryptosporidiosis is a leading cause of diarrheal disease worldwide and is an animal and public health burden. This study aimed to evaluate the protective potential of affinity-purified Cryptosporidium parvum oocyst antigen as a vaccine candidate according to fecal oocyst shedding, humoral and cellular immune responses, histopathological changes, and the number of parasite developmental stages in ileal and hepatic tissues.

Materials and Methods: We isolated oocysts from naturally infected buffalo calves and identified them molecularly as C. parvum isolates (GenBank: ON730707 and ON730708) by targeting the Cryptosporidium oocyst wall protein gene. We propagated the C. parvum oocysts in mice. In addition, we prepared crude antigen from the isolated oocysts by purification using cyanogen bromide-activated Sepharose-4B affinity chromatography coupled with rabbit hyperimmune serum. Then, we divided 81 parasite-free mice into three groups: (1) non-vaccinated non-infected mice, (2) mice orally infected with 1 × 105 C. parvum oocysts on week 4 of the experiment, and (3) mice immunized twice with 40 μg/kg of the purified fraction at 2-week intervals. Then, we challenged the vaccinated group with C. parvum oocysts after 2 weeks, and the positive control group was infected at the same time.

Results: We observed a prolonged prepatent period and decreased oocyst shedding in the vaccinated infected mice compared with the non-vaccinated infected mice (t < 0.001). The vaccinated mice had significantly higher immunoglobulin G levels than those in the other two groups at all examined weeks. In addition, the production of cytokines interferon-gamma, interleukin (IL)-10, IL-12, and IL-15 was activated post-vaccination. After the challenge, all tested cytokines were significantly increased (p < 0.001) in the two infected groups compared with the non-vaccinated non-infected group, with the highest levels in the vaccinated infected group. Vaccinated infected mice exhibited significantly fewer pathological lesions in the ileum and liver than non-vaccinated infected mice, which showed prominent histopathological lesions. Endogenous developmental stages of C. parvum indicated that the ileum was more parasitized than the liver and that vaccination resulted in a lower number of oocysts in ileal and hepatic tissues (p < 0.05).

Conclusion: Our prepared affinity-purified vaccine candidate could be promising in protecting against cryptosporidiosis.
Impact of Urban Land Use on Rainwater Quality
Authors: Agaja Toluwalope Mubo , Towobola David Olaoluwa
Published: December 2022

This study assessed the physicochemical properties of rainwater in the urban land uses and observed the associated relationship between urban land uses and the physicochemical properties of rainwater. A total of 10 rainwater samples was collected and analysed for 15 physicochemical parameters namely: colour, conductivity, pH, total dissolved solids, turbidity, aluminium (Al3+), copper (Cu2+), iron (Fe2+), nitrate (NO3-), lead (Pb2+), nickel (Ni), sodium (Na+), phosphorus (K+), zinc (Zn2+) and sulphate (SO42-). Mean, standard deviation, coefficient of variation, Pearson correlation coefficient were used in the summary, analysis and interpretation of the results. The result reveal that the urban land uses and rainwater quality has a significant relationship in Ilorin Metropolis. Agricultural, industrial and institutional land uses have the least significant effect on the quality of rainwater with the significant value of 0.044, 0.035 and 0.014 (P<0.05) respectively. Residential land use has poor rainwater quality with significant value of 0.724 while commercial land use has fairly good quality with 0.585 (P>0.05). The study concludes that the urban land uses has an impact on the rainwater quality. The study recommends that rainwater be purified before drinking and sustainable urbanization policies be developed to prevent atmospheric pollution in Ilorin Metropolis.
Enhancing plant genome editing through the use of a flexible CRISPR-Combo system
Authors: Nandi Amartya , M. Kewlani Aman
Published: December 2022

Plant genome engineering has greatly benefited from the use of CRISPR-Cas9, its derived base editors, and CRISPR activation systems. However, since these systems are typically used independently, their combined potential is largely unrealized. We create a flexible CRISPR-Combo platform for simultaneous genome editing (targeted mutagenesis or base editing) and gene activation in plants here, based on a single Cas9 protein. We highlight the effective CRISPR-Combo applications for enhancing plant genome editing. By activating the florigen gene in Arabidopsis, CRISPR-Combo is used to shorten the plant life cycle and reduce the effort required to screen transgene-free genome-edited plants. We then use the activation of morphogenic genes in poplar to show how genome-edited plants can regenerate and reproduce more quickly. Additionally, we use CRISPR-Combo, which is recognized as a new technique to primarily enrich heritable targeted mutations, to achieve rice regeneration without the use of exogenous plant hormones. As a versatile tool for genome engineering, CRISPR-Combo has potential uses in crop breeding.
Deposition of polymeric thin films from propane-butane in atmospheric pressure discharge
Authors: Mazánková V. , Kostyleva K. , Horňák R. , Sťahel P.
Published: December 2022

In our experimental work we prepared thin films via plasma polymerisation and characterized them. These films were prepared on a glass substrate in the dielectric barrier discharge (BDB). The wettability of the deposited layers was determined by measuring of the contact angle and the free surface energy of the layers using the SEE system apparatus. The atomic composition and the surface morphology of the thin layers was characterized by scanning electron microscopy (SEM). Performed biological tests of biocompatibility and antibacterial properties provided information on the viability of the cells on the layers and their antibacterial effects.
A Pilot Study to Improve Instructional Competencies of Graduate Students for Teaching Students with Learning Disabilities: Based on Syllabus Content Analysis
Authors:   Center For Educational Research, Jung Pyung-Gang , Lee Yedana , Yun Joonmo
Published: December 2022

Purpose: Highly qualified educators are essential to teach students with Learning Disabilities(LD), who need intensive, individualized instruction. In this study, we conducted a pilot study with graduate students to examine directions to improve instructional competencies required for teaching students with LD. Methods: We explored the degree to which special education LD courses reflect CEC standards, consisting of essential knowledge and skills of professionals for teaching students with LD, by analyzing ten syllabi from graduate programs. Results: The “program, service, and outcome,” associated with evidence-based instructional strategies for students with LD, generally showed the highest proportion, whereas “collaboration” showed the lowest proportion of the total standards in the syllabi. Conclusion: Implications and future directions for training high-quality special educators in special education graduate programs are discussed.
A Literature Review on Adaptive Practice of Teachers: Focusing on Network Analysis
Authors:   Center For Educational Research, KIM HEE KYONG , Kim Yejin
Published: December 2022

Purpose: The purpose of this study was to analyze research papers of teachers’ adaptive practices published in the last ten years through theoretical considerations on the concept and factors of teachers' adaptive practices for examining the characteristics of teachers’ adaptive practice and related factors and to suggest future research directions and implications for teacher education. Methods: For this purpose, a total of fifty-four papers on adaptive practices published in the last ten years searched in ERIC database were analyzed for an adaptive practices’ definition, factors, and effects, and the definitions of adaptive practices were analyzed with network analysis. Results: As a result of the analysis, first, teachers' adaptive practices occur to help learning in response to new, uncertain, or non-routine teaching and learning situations or to individual learners' various responses. This could be viewed as the active controlled behavior of teachers. Second, reflective thinking, flexibility, knowledge, and experience of teachers are required as important teacher factors for the adaptive practices of teachers. As for environmental factors, adaptive practices are limited in a uniform education policy or evaluation system, and are promoted in an environment that is open and supports various attempts. Third, it was found that the teachers’ adaptive practices help to improve learning achievement and enhance students’ interest and participation in class, and it was helpful for teachers to improve expertise and lifelong learning ability, and to establish a teacher's identity. Conclusion: Considering the results of the analysis, the adaptive practice of teachers is one of the important areas of teachers’ expertise. To further improve in this area, it is important to understand the nature of unpredictable educational environments, to develop reflective thinking and flexibility, and to provide opportunities for professional development that can build a repertoire of adaptation cases through various challenges.
Algumas considerações Ã respeito do objeto de estudo da biogeografia
Authors: Camargo José Carlos Godoy
Published: December 2022

Neste artigo procuramos evidenciar algumas caracteristicas da biogeografia, tais como a sua complexidade, objeto de estudo, campo e método e como ela pode ser desenvolvida pelos geografos
Planteamiento del problema de un proyecto de investigación: escritura y formulación en ciencias de la salud
Authors: Vergara-Jaimes Silvia Margarita , Botero-Bolívar Sara , Donado Gómez Jorge Hernando
Published: December 2022

El planteamiento del problema de investigación es el punto de partida de toda investigación científica y es de vital importancia que se realice adecuadamente. Por esta razón, es fundamental tener claro que el desarrollo de un adecuado problema de investigación es un proceso complejo y va a estar compuesto por cinco partes. En primer lugar, se debe definir la condición clínica de interés y tener total claridad sobre ella; se recomienda escribir una pequeña descripción de la enfermedad que sirva como marco de referencia para el problema. Posteriormente, se debe expresar el problema en términos de una situación adversa o negativa (morbilidad, mortalidad, costos, entre otros), bien sea para el paciente, su familia, el sistema de salud o la sociedad. En tercer lugar, el problema de investigación implica que haya un vacío o discrepancia en el conocimiento sobre dicha situación negativa; para identificarlo, es necesario llevar a cabo una revisión sistemática de la literatura con el fin de tener presente las respuestas encontradas en investigaciones previas. Luego, se deben estimar las implicaciones o beneficios prácticos que pueda traer el resolver dicho problema. Finalmente, el problema de investigación se debe concretar de forma justificada y estructurada dando lugar a la pregunta de investigación. Además, el investigador debe estar en la capacidad de determinar si su pregunta de investigación cumple con los elementos necesarios para ser adecuada, las cuales se resumen en la mnemotecnia FINER (factible, interesante, novedosa, ética y relevante).
SHADOW EFFECT FROM LAFFER TAX ALLERGY: NEW TAX POLICY TOOL TO FIGHT TAX EVASION
Authors: DOMBOU Dany R. T.
Published: December 2022

This study is inspired by the Laffer curve to develop and formalize a concept around optimal tax policy considering asymmetric information. This is the "Shadow effect". This theory states that when the tax burden is high, producers tend to inflate their fictitious expenses to reduce their declared profit (to avoid paying a high tax). The theoretical developments show that the propensity of producers to the Shadow effect is positively related to the square of the tax rate. The relationship is non-linear. They also show that there is an inverse and non-linear relationship between the tax rate and the level of production. Also, producers' sensitivity to the Shadow Effect can be influenced by fluctuating the tax burden. This study provides governments a new fiscal policy tool. For instance, a numerical application has shown that if the Cameroonian government wants to encourage production in such a way that it could reach 50% more, it should reduce the corporate tax rate down ceteris paribus, to 16.19%.
INEQUALITY AND GROWTH IN TUNISIA: EMPIRICAL EVIDENCE ON THE ROLE OF MACROECONOMIC FACTORS
Authors: MBAZIA Nadia
Published: December 2022

The purpose of this paper is to explore the relationships between income inequality, economic growth and the main macroeconomic factors in Tunisia. We investigate two effects:  the effect of inequality on growth, and particularly, the effect of growth on inequality. Also, attention has been focused on the role of the monetary policy, via introducing money supply as an independent variable, in affecting inequality and growth. Our empirical study is based on a series of annual data from 1975 to 2015 using the Dynamic Ordinary Least Squares (DOLS) method in order to estimate the cointegrating equations. The findings of the paper show that income inequality increase economic growth in Tunisia. Other factors having significant positive effect on economic growth include money supply and life expectancy at birth. However, inflation rate, primary education and unemployment have statistically significant and negative effect on economic growth. On the other hand, the results indicate that money supply, inflation rate, unemployment and savings are positively and significantly related to income inequality, whereas, life expectancy at birth and gross fixed capital formation decrease inequality in Tunisia. The policy implications of these results are discussed.
MONETARY POLICY OF GEORGIA IN XI-XII CENTURIES AND ITS INFLUENCE ON THE INTERNATIONAL FINANCIAL AND ECONOMIC RELATIONS
Authors: ABUSELIDZE George
Published: December 2022

This works we have researched the matters of formation of monetary policy of feudal age and their effect on development of foreign trade, methods of money formation important for the present world, which correct choice may provide increase of production volume and economic activity. Currency policy, geopolitical and geostrategic localization proved the country to turn into one of the economically strong economic states with high standard of life, developed system of socioeconomic relations approached to the international standards and democratic institutions.
THE LINK BETWEEN MIGRATION, REMITTANCES AND ECONOMIC GROWTH: EMPIRICAL EVIDENCE FROM ROMANIA
Authors: PIRVU Ramona , BADARCEA Roxana , MANTA Alina , FLOREA Nicoleta
Published: December 2022

The paper investigates the causal link between remittances and economic growth in Romania. Starting from the debates regarding the relative contribution of international migrants’ remittances to sustainable economic development, this paper proposes an econometric analysis of the effects of remittances on the Romanian economy. The article shows that remittances have a positive effect on the current account of external balance of payments and they can replace external financial assistance flows, including foreign loans. Significant inflows of remittances can offset the current account deficit of the balance of payments, reducing the likelihood balance of payments crisis. At the same time remittances will increase aggregate demand, which has the effect of increasing inflation, currency appreciation and widening trade deficit. We showed also that remittances can exert positive influences on the process of investment, especially through the creation of numerous small enterprises.
Perspectivas o tipologías para abordar los problemas de investigación del derecho
Authors: Carvajal Martínez Jorge Enrique
Published: December 2022

Los dilemas respecto de la investigación en general, cotidianamente, están dirigidos hacia la validación del conocimiento que postula el investigador. La comunidad académica receptora de la información está atenta a verificar la validez de los aportes o de un nuevo paradigma o, por el contrario, desacreditar la demostración pretendida de las tesis. En las ciencias causalistas o nomotéticas el deber de escrutinio resulta ser mucha más escueto, debido a la preponderancia del supuesto ontológico que califica la realidad como objetiva y aprehendida a través de un proceso cognitivo (Solis, 2005). Al contrario, en las ciencias de la sociedad, la discusión es amplia y difícilmente tiene una respuesta inequívoca.
Dalla condizione terrestre all’ambiente planetario nei Canti di Giacomo Leopardi
Authors: Loba Mirosław
Published: December 2022

This article examines the representation of the environment in the Canti by Giacomo Leopardi. The author seeks to show the Leopardian environment as a place where history, nature and the cosmos intersect. The immensity and simultaneity of these three elements determines the way the lyric subject inhabits the world. Leopardi’s poetic focus is on his painful experience of the environment, which remains an indifferent and destructive agent. The poet deconstructs classical and romantic models of nature and culture by appealing to the aesthetics of the sublime, which unlike Kant is not the means of understanding but the way to experience the planetary character of existence.
Ecolirica e “umanesimo ambientale” nell’opera tarda di Andrea Zanzotto
Authors: Baldacci Alessandro
Published: December 2022

The article focuses on the denunciation of the environmental catastrophe as the central hub of the late works of Andrea Zanzotto, from Haiku. For A Season, composed during the first half of the 1980s, to his latest book, Conglomerati (2009). Starting from the poet’s awareness of writing from within an unprecedented environmental crisis, the analysis aims to highlight the “ecological potential” of his poetry, the novelties it presents, after Idioma, moving ever more dramatically and paradoxically between the utopiaof the garden, as a symbol of harmony, and the infernal one of the forest, to indicate the degeneration of human action and its nefarious effects on the entire planet. Thus emerges the ability of this poet to transform his texts into pedagogical “planetary gardens”, in which to cultivate resistance strategies that are given within the same ecosystem. In conclusion, the article aims to underline how, in its late phase, Zanzotto’s poetry presents itself in the form of an “environmental humanism” that involves every living form and raises the need for a different way of inhabiting the earth in the times of the Anthropocene.
L’ambiente psichiatrico nell’opera di Franco Basaglia e Mario Tobino: verso un’ecologia delle idee (sulla follia)
Authors: Redaelli Stefano
Published: December 2022

The aim of the article is to compare the reform and the narration of the psychiatric environment in the work of Franco Basaglia and Mario Tobino from an ecological perspective. Both psychiatrists worked to reform the asylum spaces and the therapeutic relationships within it. Their actions and their narrations were both ecological but had an opposite ending. While Tobino defended until the end the idea of a safe psychiatric environment, protected by society, considered dangerous, Franco Basaglia strongly affirmed the repressiveness of the asylum space, the need to dismantle it and return the madness to society.
Zakaz łączenia funkcji z członkostwem w zarządzie spółki kapitałowej – zagadnienia wybrane
Authors: Mizerski Dominik
Published: December 2022

W artykule przedstawiono najważniejsze instytucje prawne ograniczające lub wyłączające pełnienie przez członków zarządu określonych funkcji. Opisano m.in. zakaz łączenia stanowisk członka zarządu z członkostwem w radzie nadzorczej tej spółki oraz poruszono problematykę dopuszczalności ustanawiania członków zarządu spółki jej pełnomocnikiem czy prokurentem. W opracowaniu poruszono także problematykę sankcji za złamanie nałożonych na członków zarządu zakazów oraz ograniczeń w pełnieniu innych funkcji ze wskazaniem rozbieżności w doktrynie oraz orzecznictwie w zakresie konsekwencji naruszenia powyższych ograniczeń.
Umowa przewłaszczenia nieruchomości na zabezpieczenie z uwzględnieniem nowej regulacji art. 387 Kodeksu cywilnego
Authors: Komar Wojciech
Published: December 2022

Celem artykułu jest przeanalizowanie instytucji przewłaszczenia nieruchomości na zabezpieczenie oraz nowej regulacji kodeksu cywilnego. Poddano analizie dopuszczalność, formę i konstrukcję umowy. Badanie objęło prawa i obowiązki stron umowy, w szczególności przejście własności i zaspokojenie wierzytelności. Przedstawiono wybrane kontrowersyjne problemy podnoszone w doktrynie i orzecznictwie, m.in. obejście prawa przy przenoszeniu własności. Analizowany jest kształt, cel i skutki nowej regulacji w Kodeksie cywilnym. Opisane zostały przesłanki nieważności umowy wprowadzone nowelizacją.
Przewidywany termin rozpoczęcia i zakończenia robót budowlanych przy zabytku a termin ważności pozwolenia wojewódzkiego konserwatora zabytków
Authors: Krzanowski Marcel
Published: December 2022

Niniejszy artykuł porusza tematykę obowiązywania w czasie pozwoleń wojewódzkiego konserwatora zabytków. Na jego łamach dochodzi do polemiki ze stanowiskiem sądów administracyjnych, uznających przewidywany termin rozpoczęcia i zakończenia robót budowlanych przy zabytku wpisanym do rejestru zabytków za jedynie informacyjny oraz niewywołujący skutków prawnych. Autor przedstawia argumenty przemawiające za koniecznością przyjęcia odmiennej optyki, tj. uznania, że termin ten służy ograniczeniu obowiązywania w czasie decyzji administracyjnej. W praca podejmowana jest rownież problematyka zgodności z Konstytucją obecnie obowiązujących rozwiązań. Chodzi o dopuszczalność określania w drodze aktu podustawowego elementów akcesoryjnych decyzji administracyjnej.
The “Normative Turn” in Sociological Theory: Sociology’s Garden of the Forking Paths
Authors: Chernilo Daniel , Raza Sebastian
Published: December 2022

In his “The Garden of the Forking Paths,” Argentinean storyteller Jorge Luis Borges devises an ever-growing maze of diverging and converging paths. While the underlying structure of these paths is the explicit object of his quest, the protagonist becomes increasingly aware that, in fact, his quest mirrors such big questions as the nature of space and time. We use this provocative image to kick off our much more modest quest on the current state of sociological theories of normativity that have become salient in the past three decades. What once seemed to be the specific object of critical theory, as it has constantly shown a special sensibility towards normative issues, is now a pressing theme in various theoretical traditions, and perhaps the very universe in which divergent sociological worlds concatenate with each other. We focus on three traditions that have made clear progress in explicitly analysing what is the normative: Neo-Durkheimianism, Neo-pragmatism, and Critical Realism. We identify their more salient aspects and reflect on their similarities and differences. We conclude that, to all three, normative ideals are congealed in social “facts” that cannot be explained, naturalistically or mechanistically, in causal terms. Equally, they all make apparent the autonomy of normative ideals in the structure of human agency by focusing on different aspects of it. Finally, we reflect on the different temporal dimension on which they focus: spaces of ritualism to past normative commitments (Neo-Durkheimians); spaces of reasons to present problematic events (Neo-pragmatism); and spaces of aspirations to imagined future states (Critical Realism).
Hydro-Climatic Variability of the Ogooue Watershed in Lambaréné
Authors:   Omar Bongo University, J. D. Maloba Makanga , Igaly E. Mbadinga
Published: December 2022

Located in the center-west of Gabon, the city of Lambaréné is frequently affected by floods which cause material, economic and health damage. This scientific contribution presents the preliminary results of a larger study on the risks of flooding in the Ogooué basin in Lambaréné. The analysis of the flows (1959-1989), water levels (2000-2010) and rainfall common to both time periods shows that the most favorable period for floods corresponds, among others, to the months of October and November that record abundant precipitation, at the origin of the main hydrological peaks of November-December. In general, there is an evolution in phase between the pluviometric positive anomalies, flows and water heights likely to cause overflows of the waters of the Ogooué. Key words: Gabon, rainfall, water level, variability
Pain and physical activity for one individual
Authors: Leppink Jimmie
Published: December 2022

Aims: there is increasing awareness that for effective patient care we need more than only randomized controlled trials with groups of participants and that carefully collected single case (N = 1) data have several important advantages over traditional group-level studies. With the advance of technology, collecting relevant data from a single case is becoming easier by the day, and this offers tremendous opportunities for understanding how behaviors displayed by an individual can be influenced by one or several key variables. For example, how pain experienced influences the amount of time spent on physical exercise. Method: using publicly available observational single case data, five models are compared: a classical ordinary least squares (OLS) linear regression model; a dynamic regression model (DRM); a two-level random-intercepts model (2LRI); a continuous covariate first-order autoregressive correlation model (CAR1); and an ordinary least squares model with time trend (OLST). These models are compared in terms of overall model fit statistics, estimates of the relation between physical activity (response variable of interest) and pain (covariate of interest), and residual statistics. Results: 2LRI outperforms all other models on both overall model fit and residual statistics, and provides covariate estimates that are in between the relative extremes provided by other models. CAR1 and OLST demonstrate an almost identical performance and one that is substantially better than OLS – which performs worst – and DRM. Conclusion: for observational single case data, DRM, CAR1, OLST, and 2LRI account for the serial correlation that is typically present in single case data in somewhat different ways under somewhat different assumptions, and all perform better than OLS. Implications of these findings for observational, quasi-experimental, and experimental single case studies are discussed.
“Por isso cuidado meu bem, há perigo na esquina” – ditadura militar, SPI e os povos indígenas de Rondônia no Relatório Figueiredo
Authors: Neves Josélia Gomes
Published: December 2022

O Relatório Figueiredo (RF) é um documento resultante de uma apuração sobre violações cometidas especificamente contra os povos indígenas brasileiros pelo Serviço de Proteção aos Índios (SPI) no período da ditadura militar. Tem contribuído para compreender como as forças militares no poder materializavam as relações de rotina com as populações originárias nesta época. Estas premissas mobilizaram a presente agenda de pesquisa cuja finalidade foi analisar as violações dos direitos humanos contra os povos indígenas do Território Federal de Rondônia nos anos de 1965 e 1966, mediante atuação da 9ª Inspetoria Regional, localizada em Porto Velho. A metodologia adotada foi a pesquisa documental descritiva e analítica que possibilitou o reexame do Relatório Figueiredo, um conjunto de 30 (trinta) volumes sistematizados no final dos anos 60. A conclusão da pesquisa evidenciou que os arquivos do RF possibilitaram o conhecimento da memória histórica que explicitou prejuízos contra os povos indígenas produzidas pelo SPI durante o regime militar em Rondônia. Explicitou que a expectativa de proteção deste órgão indigenista se transformou em dilapidação, apropriação e exploração do patrimônio indígena por meio de duvidosas relações público-privadas. Os efeitos dessas ações se traduziram em um conjunto de violações para os direitos humanos das comunidades originárias nesta parte da Amazônia brasileira, elementos que podem impulsionar aprofundamentos em busca de reparação e justiça social.
High-performance liquid chromatography evaluation of lipophilicity and QSRR modeling of a series of dual DNA gyrase and topoisomerase IV inhibitors
Authors: Dobričić Vladimir , Savić Jelena , Tomašič Tihomir , Durcik Martina , Zidar Nace , Mašič Lucija Peterlin , Ilaš Janez , Kikelj Danijel , Čudina Olivera
Published: December 2022

Bacterial DNA gyrase and topoisomerase IV control the topological state of DNA during replication and represent important antibacterial drug targets. To be successful as drug candidates, newly synthesized compounds must possess optimal lipophilicity, which enables efficient delivery to the site of action. In this study, retention behavior of twenty-three previously synthesized dual DNA gyrase and topoisomerase IV inhibitors was tested in RP-HPLC system, consisting of C8 column and acetonitrile/phosphate buffer (pH 5.5 and pH 7.4) mobile phase. logD was calculated at both pH values and the best correlation with logD was obtained for retention parameter φ0, indicating that this RP-HPLC system could be used as an alternative to the shake-flask determination of lipophilicity. Subsequent QSRR analysis revealed that intrinsic lipophilicity (logP) and molecular weight (bcutm13) have a positive, while solubility (bcutp3) has a negative influence on this retention parameter.
A digitális technológia kínálta új lehetőségek a melanoma malignum szűrésében.
Authors: Farkas-Ráduly Szabolcs , Csanádi Marcell , Ágh Tamás , Szász Orsolya , Vokó Zoltán , Széles György
Published: December 2022

Bevezetés: A kelet- és közép-európai régióban – Csehországot és
Szlovákiát követve – Magyarországon a harmadik legmagasabb a melanoma malignum
incidenciája. A melanomaszűrés és -diagnosztika hatékonyságának javítására az
elmúlt években számos technológiai fejlesztés történt: az egyik ilyen, széles
körben ismertté vált technológia az integrált automatizált
teljestest-feltérképezés és digitális dermatoszkópia.
Célkitűzés: A jelen célzott irodalomkutatás célja, hogy
bemutassa a teljestest-anyajegyvizsgálatra kifejlesztett új digitális
technológiákban rejlő lehetőségeket a melanomaszűrésre vonatkozóan.
Módszer: A melanomaszűrésre és
teljestest-anyajegyvizsgálatra alkalmas szűrési technológiára vonatkozó
információk összegyűjtésére célzott irodalomkutatást végeztünk. Publikusan
elérhető online adatbázisokban kerestünk szakmai irányelveket és ajánlásokat,
valamint tudományos közleményeket. Eredmények:
Irodalomkeresésünk során 15 nemzetközi irányelvet és ajánlást azonosítottunk,
melyek a melanoma malignum szűrését és korai felismerését összegezték.
Melanomaszűréssel foglalkozó hazai irányelvet nem azonosítottunk. A digitális
dermatoszkóp és a teljestest-anyajegyvizsgálatra alkalmas szűrési technológia
eredményességére vonatkozóan 2 klinikai, 5 megfigyeléses vizsgálatot és 8
összefoglaló közleményt elemeztünk. 10 nemzetközi vizsgálatot elemeztünk, melyek
a gépi tanulási algoritmusok kiegészítő szerepét vizsgálták a melanomaszűrésben.
Megbeszélés: A digitális dermatoszkópia és a teljes testről
készült fényképfelvételek elősegítik a rosszindulatúvá váló képletek vagy az új
melanoma azonosítását magas kockázatnak kitett személyekben. Nem áll
rendelkezésre megbízható adat a melanomaszűrő-programoknak a daganat okozta
halálozásra kifejtett hatásáról, így a korlátozott bizonyítékok miatt a
populációs szintű melanomaszűrést a nemzetközi irányelvek nem ajánlják.
Következtetés: Megállapítható, hogy a nemzetközi irányelvek
kiemelik a teljes testről készült fényképfelvételek és a szekvenciális digitális
dermatoszkópos képalkotó eljárások szerepét a melanoma emelkedett kockázatának
kitett személyek szűrésében. Orv Hetil. 2022; 163(49): 1943–1951.
Milky Way
Authors: Brady Bernadette
Published: December 2022

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“Milky Way Astronomies”
Authors: López Alejandro Martín
Published: December 2022

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Commentary on Ibrahim Allawi’s “Some Evolutionary and Cosmological Aspects of Early Islamic Town Planning”
Authors: Kamola Stefan
Published: December 2022

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¿Es la dirección escolar un trabajo apasionante? Evaluación de la pasión en directivos de Chile y Cataluña
Authors: Rodríguez-García Eva , Longás-Mayayo Jordi , Chamarro-Lusar Andrés , Riera-i-Romaní Jordi
Published: December 2022

Según la literatura, el incremento de la complejidad en la gestión de los centros educativos podría explicar la escasez de candidaturas para la dirección escolar y el agotamiento y deserción de directivos. No obstante, los directivos se muestran satisfechos y apasionados por su trabajo. El objetivo de este estudio es analizar los niveles de pasión en profesionales de la dirección escolar mediante la escala de la Pasión (Marsh et al., 2013) y su relación con variables profesionales. Los resultados muestran altos niveles de pasión y pasión armoniosa entre los sujetos de la muestra, tanto en Chile como en Cataluña.
El bienestar emocional de los docentes como factor determinante en los procesos de enseñanza/aprendizaje en el aula
Authors: López-Martínez Olivia , García-Jiménez Elena , Cuesta-Sáez-de-Tejada José-David
Published: December 2022

En el siguiente trabajo hemos analizado el estado emocional de los docentes de Educación Infantil y Educación Primaria. Participaron 300 docentes de la provincia de Granada (España), 113 de Educación Infantil y 187 de Educación Primaria, con edades comprendidas entre 25 y 64 años. La metodología es descriptiva y comparativa transversal. Los resultados confirman que: 1) los docentes puntúan más alto en las dimensiones positivas analizadas que en las negativas, sobre todo los que han realizado cursos o actividades para mejorar su bienestar personal; 2) existe relación significativa de la edad con la felicidad, la claridad, la autoestima total y su dimensión positiva.
FORMAÇÃO CONTINUADA DE PROFESSORES PARA EDUCAÇÃO PROFISSIONAL E TECNOLÓGICA
Authors: Silveira Joanna Aretha , Santiago Silvany Bastos , Rodrigues Bárbara Suellen Ferreira
Published: December 2022

O artigo discute a formação continuada para docentes da Educação Profissional e Tecnológica (EPT). Para tanto, inicialmente, apresenta um breve histórico sobre a formação de professores desta modalidade de ensino. Em seguida, mostra uma discussão sobre a formação continuada, a importância das experiências e dos saberes docentes. Em um terceiro momento, discorre sobre ideias, propostas de formação no contexto da EPT realizadas por autores, como Moura (2014), Machado (2008), Oliveira e Mororó (2018), Tardif (2014), que embasam o estudo. Por fim, conclui apresentando alguns desafios postos na atualidade para a formação docente na EPT e coloca como indispensável que a formação docente possa ter como base a realidade vivida pelos professores, além de ver como relevante os conhecimentos construídos na prática, ao longo da profissão, sem desconsiderar os saberes teóricos da educação. O trabalho é de cunho bibliográfico e documental.
IMPACTOS DA PANDEMIA DA COVID-19 NA EDUCAÇÃO DE JOVENS E ADULTOS NA REDE MUNICIPAL DO RIO DE JANEIRO
Authors: Barbosa Carlos Soares
Published: December 2022

Este artigo objetiva refletir os impactos causados pela pandemia da Covid-19 na Educação de Jovens e Adultos (EJA), na rede municipal de educação do Rio de Janeiro, face aos novos desafios vivenciados na modalidade provocados pelo fechamento de escolas e a realização das atividades escolares mediadas por tecnologias digitais. Trata-se de resultado da pesquisa exploratória, realizada entre maio e junho de 2020, cujo procedimento de dados se fez por meio de entrevistas com cinco professores da modalidade e com o subgerente da Gerência de Educação da SME-RJ. Os dados indicam a inconsistência do ensino remoto para a modalidade, face à pouca relação dos educandos com a tecnologia, o baixo acesso à internet, as precárias condições de moradia e a necessidade dos educandos – trabalhadores e chefes de família – terem de criar novas estratégias para garantir a produção da existência diante da nova condição de desemprego