bluuebunny/crossref_metadata_2025 huggingface dataset:
PO-144 Intermittent Exercise Activates NRG1-SERCA2a Pathway to Improve Cardiac Function in Myocardial Infarction Rats
Authors: Bo Wenyan , Li Dagang , Tian Zhenjun
Published: October 2018

Objective  Intermittent exercise can improve cardiac function in rats with myocardial infarction. The Neuregulin-1(NRG1)/SERCA2a palys a critical role in maintain cardiac function. We want to investigate the effect of Neuregulin-1 (NRG1) on NRG1-SERCA2a signaling pathway activated by intermittent exercise and on improves cardiac function in rats with MI.

Methods 32 male sprague-dawley rats were randomly divided into four groups (n=8): Sham-operated group (S), sedentary MI group (MI), MI with interval training group (ME), ME with inhibitor AG1478 group (MA). ME and MA model after the MI model was established by ligation of the left anterior descending coronary artery, and began training 1 week after MI surgery. The S model only by threading without ligation. Rats in ME and MA model taken one week adaptive training, then began 8-week interval training. MA model were injected with inhibitor AG1478, once every two days. The 24h after training, rats were anesthetized, the LVSP, LVEDP, ±dp/dt max were tested by carotid artery intubation which in order to evaluate cardiac function. The protein expression of NRG1, PI3K, Akt, eNOS, PKG, PLN, SERCA2a in myocardium were measured by Westernblotting, themRNA expression of serca2a were tested by RT-qPCR.

Results Compared with S, the protein expression of NRG1, PKG, peNOS, pAkt, pPLN, pPI3K and SERCA2a decreased, serca2a mRNA expression decreased, LVSP and ±dp/dt max significantly decreased, LVEDP significantly increased; Compared with MI, the protein expression of NRG1, PKG, peNOS, pAkt, pPLN, pPI3K and SERCA2a increased, serca2a mRNA expression increased, LVSP and ±dp/dt max significantly increased, LVEDP decreased, and the effect of exercise were weaken by inhibitor AG1478. Correlation analysis showed that the myocardial pPLN and SERCA2a protein expression both were positively correlated with LVSP, ±dp/dtmax, and negatively correlated with LVEDP.

Conclusions Intermittent exercise can increased myocardial NRG1 protein expression and activates NRG1-SERCA2a signaling pathway, improve myocardial infarction cardiac function.
PO-190 Exercise Training Protects Against Cardiac Pathological Remodeling in Myocardial Infarction rats via Improving Mitochondrial Biogenesis
Authors: Jia Dandan , Tian Zhenjun
Published: October 2018

Objective  Growing evidence suggests that exercise training reverses cardiac pathological remodeling and cardiac dysfunction during myocardial infarction (MI), but the underlying mechanisms have not been fully understood. In this study, we investigated the impact of exercise training on cardiac function, myocardial fibrosis, apoptosis, oxidative stress and mitochondrial biogenesis.

Methods Sprague Dawley rats were subjected to MI by permanent ligation of the left anterior descending (LAD) coronary artery or Sham operation. Rats with MI were randomly assigned to sedentary MI group (MI) and MI with exercise training group (MI+EX), and compared to sham-operated group (Sham). Haemodynamics and Masson staining were conducted to evaluate the effect of exercise training on cardiac function and myocardial fibrosis. Myocardial apoptosis, oxidative stress, mitochondrial biogenesis and molecular signaling mechanism were analyzed.

Results  Exercise training significantly improves cardiac function and mitigates the MI-induced cardiac pathological remodeling. Meanwhile, Exercise training significantly attenuates MI-induced apoptosis, oxidative stress and mitochondrial biogenesis. In addition, activation of PI3K pathway following MI is further induced by exercise training.

Conclusions  Exercise training protects against MI-induced cardiac dysfunction and pathological remodeling through preventing myocardial apoptosis and oxidative stress, and enhancing mitochondrial biogenesis.
KONTRIBUSI PERADILAN ADAT DAN KEADILAN RESTORATIF DALAM PEMBARUAN HUKUM PIDANA DI INDONESIA
Authors: Rochaeti Nur , Sutanti Rahmi Dwi
Published: October 2018

Keadilan menurut masyarakat adat dimaknai sebagai suatu konsep yang bersifat kompleks, karena tidak hanya dapat diberikan oleh pengadilan formal, namun juga dapat diberikan oleh forum lain seperti peradilan adat. Penelitian ini bertujuan untuk menganalisa kontribusi peradilan adat dan keadilan restoratif dalam pembaruan  hukum pidana di Indonesia. Pendekatan yang digunakan dalam penelitian ini adalah kajian sosio-legal (socio-legal study).Hasil penelitian menunjukkan peradilan adat dan keadilan restoratif di Indonesia telah dilakukan melalui partisipasi anggota masyarakat dengan karakteristik tradisional hukum, pluralisme budaya, nilai-nilai moral, dan agama dalam rangka memecahkan masalah melalui konsultasi untuk mencapai kesepakatan. Peradilan adat dan keadilan restoratif di Indonesia dilakukan dengan mediasi untuk kesepakatan untuk mencapai kesepakatan demi kepentingan terbaik bagi korban, pelaku, keluarga, dan pihak-pihak lainnya yang berkaitan dengan karakteristik tradisional hukum, pluralisme budaya, nilai-nilai moral, dan agama.
DISPARITAS DALAM PENJATUHAN PIDANA
Authors: Gulo Nimerodi
Published: October 2018

Rumusan norma yang berkaitan dengan ancaman pidana pada dasarnya bersifat maksimum. Hal tersebut menimbulkan ruang disparitas putusan hakim. Disapritas tersebut dapat menimbulkan rasa ketidakadilan (keadilan substantif) bagi terpidana. Rumusan masalahnya adalah,  apa yang menjadi faktor penyebab terjadinya disparitas pidana dalam penjatuhan pidana yang dilakukan oleh hakim dan apakah yang menjadi dasar pertimbangan hakim dalam memutus perakara pidana didalam persidangan?. Metode penelitian yang digunakan adalah metode normatif dan empiris dalam kaitannya dengan keadilan substantif. Hasil penelitian menunjukan dalam memutuskan perkara hakim tunduk pada Pasal 197 KUHAP, yaitu hakim harus memiliki pertimbangannya sendiri didalam menentukan berat atau ringannya hukuman yang akan dijatuhkan kepada terdakwa, melalui pembuktian materil dipersidangan untuk mendukung kesimpulan dalam pertimbangan hakim.  Saat ini peradilan di Indonesia masih menggunakan metode penjatuhan hukuman berdasarkan pemeriksaan persidangan saja. Hal ini menyebabkan putusan pengadilan yang dikeluarkan oleh hakim terdapat perbedaan antara satu putusan dengan putusan yang lainnya yang disebut dengan disparitas pidana.
FUNGSI REGULER PAJAK ROKOK DI BIDANG KESEHATAN MASYARAKAT DAN PENEGAKAN HUKUM
Authors: Ispriyarso Budi
Published: October 2018

Pajak Rokok adalah pungutan atas cukai rokok yang dipungut oleh pemerintah.Latar belakang diberlakukannya diadakannya pajak rokok ini antara lain adalah untuk pengendalian dampak negatif rokok. Pasal 31 ayat (1) UU Nomor 28 Tahun 2009 tentang Pajak Daerah dan Retribusi Daerah  diatur alokasi (earmarking tax) minimal50 persen dari hasil Pajak Rokok  untuk mendanai fasilitas pelayanan kesehatan dan penegakan hukum. Permasalahannya, bagaimana fungsi reguler pajak rokok yang tercermin dalam  alokasi, dilakukan oleh pemerintah daerah  dalam pelayanan kesehatan  dan penegakan hukum. Pemerintah daerah dalam melaksanakan fungsi reguler pajak rokok, harus berdasarkan undang-undang, penggunaan dana pajak rokok,minimal 50 % untuk mendanai  pelayanan kesehatan (sarana dan prasarana pelayanan kesehatan, penyediaan smoking area, kegiatan memasyarakatkan tentang bahaya merokok, dan sebagainya. Di bidang penegakan hukum, penggunaan dana rokok diperuntukan pemberantasan rokok ilegal dan penegakan aturan larangan merokok.
PENGARUH TRANSAKSI HAWALA TERHADAP TINDAK PIDANA TERORISME DI INDONESIA
Authors: Subandi Imam , Samekto Adji
Published: October 2018

Transaksi Hawala memang merupakan transaksi  yang jarang kita temukan khususnya di Indonesia namun tidak di luar negeri. Hal ini dikarenakan transaksi hawala  tersebut memang transaksi yang sangat bersifat rahasia yang menggunakan kepercayaan tingkat tinggi. Transaski hawala ini sangat memungkinkan disalah gunakan untuk kejahatan seperti pencucian uang ataupun pendanaan terorisme, namun sebenarnya Hawala juga bisa  digunakan untuk hal-hal yang baik seperti pengiriman uang  ke daerah atau Negara lain dengan waktu yang cepat dan biaya yang jauh lebih murah daripada system remittan yang dipakai perbankan. Disamping itu, mata uang tidak harus mengalami konversi. Oleh karena itu hal-hal yang akan menjadi perhatian dalam penelitian ini adalah sebagai berikut adalah bagaimana transaksaksi hawala dilakukan serta pengaruh hawala  di Indonesia khususnya terhadap tindak pidana terorisme dengan  pengaruh “HAWALA” terhadap upaya pemberantasan tindak pidana terorisme di Indonesia? . Metode penelitian yang akan digunakan  dalam penelitian ini adalah metode penelitian normatif  yang bersifat  eksplanatoris, yaitu menjelaskan secara terperinci dan sistematis  fakta-fakta  sesuai dengan kerangka pemikiran  deduktif dengan pengumpulan data  melalui library research dan Penelitian Lapangan dalam hal ini adalah pengumpulan dan pencarian  data dengan mendatangi  secara langsung instansi-instansi  yang berwenang dalam pemberantasan terorisme yakni Kepolisian Negara Republik Indonesia, khususnya Densus 88 Anti Terror, PPATK dan instansi lain yang berkaitan dengan permasalahan yang sedang diteliti, juga individu-individu yang dianggap mengetahui praktek “HAWALA”, dengan mengadakan wawancara (interview) baik secara terbuka maupun dengan teknik tertutup seperti eliciting dalam intelijen.
PENEGAKAN HUKUM TINDAK PIDANA KEKERASAN TERHADAP PEREMPUAN DI KOTA DEMAK
Authors: Sari Aldila Arumita , Purwanti Ani
Published: October 2018

Kekerasan berbasis gender merupakan fenomena sosial yang ada sejak jaman dahulu dan semakin marak akhir-akhir ini. Bahkan kekerasan terhadap perempuan, semakin meningkat, baik jumlah maupun bentuk dan modus operansinya yang semakin beragam baik di lingkup domestik (rumah tangga) maupun publik. Menurut catatan tahunan komnas perempuan pada tahun 2017 kekerasan terhadap perempuan yang paling menonjol kekerasan yang terjadi dalam lingkup rumah tangga. Kasus kekerasan terhadap perempuan semakin tinggi, terutama kekerasan terhadap perempuan dalam lingkup rumah tangga. Penulis mengangkat persoalan mengenai bagimana kebijakan formulasi tindak pidana kekerasan terhadap perempuan dan bagaimana penegakannya di kota Demak. Penelitian ini menggunakan metode Yuridis Empiris dengan menyuguhkan fakta-fakta mengenai tindak pidana kekerasan terhadap perempuan terkait dengan hukum yang berlaku di Indonesia dan bagaimana penangannya di Kota Demak, termasuk menyajikan pengalaman perempuan sebagai korban. Dari penelitian yang dilakukan diperoleh data bahwa Kebijakan Formulasi perlindungan bagi perempuan dalam instrument internasional dan nasional dapat digunakan sebagai upaya menanggulangi tindak pidana kekerasan terhadap perempuan dalam lingkup rumah tangga, khususnya setelah keluarnya Undang-undang No 23 tahun 2004. Regulasi perlindungan bagi perempuan dalam instrument internasional maupun nasional hanya berlaku apabila peristiwanya terjadi di lingkup rumah tangga, sehingga korban diluar rumah tangga tidak dapat menggunakan ketentuan hokum tersebut. Rancangan Undang Undang Kekerasan Seksual diharapkan segera disyahkan untuk melindungi dan menangani perempuan korban kekerasan baik didalam rumah tangga maupun diluar rumah.Proses penegakan hokum oleh aparat penegak hukum dalam menangani penegakan hukum tindak pidana kekerasan terhadap perempuan di Kota Demak belum optimal, karena belum baiknya koordinasi diantara stakeholder (Polisi, Jaksa, Hakim, LSM Pendamping, Pemerintah Daerah Kota Demak)
Bibliografia historii wychowania, szkolnictwa i myśli pedagogicznej w Polsce za rok 2014 (z uzupełnieniami za lata poprzednie)
Authors: Gruca Anna
Published: October 2018

Bibliografia historii wychowania, szkolnictwa i myśli pedagogicznej w Polsce za rok 2014 (z uzupełnieniami za lata poprzednie)
Inicjatywy opiekuńcze i oświatowo-wychowawcze łódzkiej społeczności żydowskiej w latach I wojny światowej – Przytulisko dla Dzieci Wyznania Mojżeszowego
Authors: Sosnowska Joanna
Published: October 2018

In 1914–1918, the Łódź Jewish community organized activities for children and teenagers in more than ten social and charitable organizations and institutions. Some of them were established even before 1914, some were opened during WWI. The Shelter for Jewish Children was among the centres operating during the difficult war times and dating back to the time before the Great War. The Shelter was established on the initiative of Sara Poznańska, wife of Maurycy Poznański, a prominent Jewish industrialist and social activist in Łódź. Members of the Board of the new institution included rich, middle class Jewish women, factory owners and merchants. In 1917, they were joined by S. Poznańska as President, Maria Hertzowa as Vice-President, Stefania Hirszbergowa as Treasurer and Paweł Becker as Secretary of the Board. Several sections were identified in the Shelter with different functions in mind: the Pedagogical, Medical, Food, Maintenance, and Clothes Sections. The task of the Pedagogical section was care for the intellectual and physical development of the children. Efforts were made to propagate Polish issues in education (the children were taught history and the Polish language). The Medical Section focused on hygiene and the children’s health. The Food Section prepared hot meals, i.e. dinners and breakfasts. The Maintenance Section’s responsibility was to develop a sense of cleanliness and order in the children. The Clothes Section put an emphasis on maintaining the children’s clothes in order, mainly by mending them. During WWI, the Shelter took care of over 200 pre-school and school children (aged 4–12).
Ks. Wacław Sierakowski – propagator wiedzy o muzyce i organizator szkolnictwa muzycznego w okresie działalności Komisji Edukacji Narodowej
Authors: Piekarski Michał
Published: October 2018

In the second half of the 18th century, musical education in Poland was poor. The Commission of National Education (1773–1793) did not take music into account in its projects. The individual willing to change the situation was Father Wacław Sierakowski (1741–1806), provost of the Wawel Cathedral in Krakow. He played a significant role in the musical life of the city as an organiser of public concerts and founder of a private music school. In 1795–1796, he published a three-volume musical textbook, The Art of Music for Young Polish People (Sztuka muzyki dla młodzieży krajowej), one of the first musical textbooks in the Polish language. In Sierakowski’s publication the stress was put on the social and national value of music. The first volume also featured Sierakowski’s petition from 1792, intended for submission before the Sejm (Polish Parliament), in which the author propounded the idea of the state taking over musical education and establishing a major statesponsored music school in Krakow (Alumnatus Vocalistarum). These plans were never carried out as the third partition of Poland ensued in 1795.
Upbringing of girls as reflected in the activities and views of Blessed Marcelina Darowska
Authors: Knop Marcelina
Published: October 2018

The article presents the life and educational activities of Blessed Marcelina Darowska, the cofounder of the Convent of the Immaculate Conception of the Blessed Virgin Mary, and her views on upbringing of young women. Mother Marcelina’s perception of education of girls in the 19th century seemed modern and beyond her time. In her opinion, there was a need of putting a stop to producing “parlour dolls” and provide young women with practical education. For the betterment of the country, she set up schools in Jazłowiec, Jarosław, Niżniów and Nowy Sącz. The girls attending the schools were brought up according to the system developed by Marcelina Darowska, based on religious and patriotic values. The Convent of the Immaculate Conception of the Blessed VirginMary continues the work commenced by its founder; over time Mother  Marcelina’s message remains valid and serves the subsequent generations of young Polish girls.
Wyjazd studyjny polskich historyków wychowania do Rumunii
Authors: Radziszewska Maria
Published: October 2018

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Struktura, zmiany organizacyjne i poziom nauczania Publicznej Szkoły Powszechnej w Brdowie w latach 1919–1939
Authors: Racinowski Dariusz
Published: October 2018

The school in Brdów dates back to the mid–15th century. It was founded and managed by Pauline fathers. In the following centuries, the school functioned with varying degrees of success. The realdevelopment of the Brdów school occurred in the interwar period. In the following years, the structure of the school changed, due to the growing number of students. Before the outbreak of World War II, there was a general public school of 3rd level, i.e. one with seven grades, in Brdów.The teachers worked under very difficult conditions. The school building was too small to accommodate all the classes. The classrooms were overcrowded. However, the educators tried to achieve the best results possible. This was confirmed by subsequent inspections conducted by educational authorities. Just before the outbreak of World War II, a new school building was opened in Brdów which greatly improved working and learning conditions there.
Koniec religii, śmierć Boga i przygodna wspólnota. Hegel, Malabou, Žižek
Authors: Wójcik Bartosz
Published: October 2018

Artykuł stanowi rozbudowaną, opartą na analizie trzech zagadnień interpretację pojęcia końca religii w filozofii G.W.F. Hegla. Po pierwsze, relacji religijnego wyobrażenia i filozofii spekulatywnej – tj. problemu zniesienia religii w filozofii. Po drugie, Heglowskiej wykładni chrześcijaństwa (przedstawionej w Encyklopedii Nauk Filozoficznych i Wykładach z filozofii religii) zogniskowanej wokół koncepcji wcielenia jako kenozy, która jest odczytywana przez pryzmat propozycji interpretacyjnej Catherine Malabou. Po trzecie wreszcie, idei śmierci Chrystusa jako śmierci samego Boga, która stanowi, zdaniem Slavoja Žižka, autentyczny rdzeń chrześcijaństwa dla Hegla. Interpretacja tych problemów prowadzi do następującej konkluzji końca religii u Hegla: uśmiercony Bóg zmartwychwstaje w Duchu Świętym, którego historyczną postacią jest „duch obiektywny‖ – rewolucyjna wspólnota czynów miłości.
Possibility of Science, Impossibility of Miracles: Léon Brunschvicg against Quentin Meillassoux
Authors: Úlfsson Tryggvi Örn
Published: October 2018

The article argues that, while Quentin Meillassoux‘s project, undertaken in After Finitude, merits attention, since the French philosopher is right that faith in sciences‘ capacity to open up new domains to thought must be restored, the solutions he offers have two serious shortcomings. 1) His depiction of science as the producer of ancestral statements does not capture satisfactorily the essence of scientific creativity. 2) The claim that everything is necessarily contingent is fundamentally incompatible with scientific knowledge. The article, then, contrasts Meillassoux‘s principle of the necessity of contingency with a principle that is extracted from the historical epistemology of Léon Brunschvicg and Antoine-Augustin Cournot. Instead of a principle of unreason, the article defends a principle of a metamorphosing reason founded on the practical impossibility of irreducible contingency.
Wiederaufbau aus dem Glauben
Authors: Buchner Maximiliane
Published: October 2018

European architecture in the second-half of the 20th century had many different roles to fulfil. Initially it sought to reconnect to what had been the ›modern style‹ before the outbreak of World War II, or rather, before the rise of National Socialism in Germany and Austria. This is true in a very special way for sacral architecture. After the human catastrophe of the Nazi regime with its destruction and desperation, all eyes were on the Church awaiting a statement. This was made not only through the erection of newly-built churches – in a density unique in the history of church building – but also in their contextual placement. The thesis of this article claims that the embedding of sacred rooms within newly-built architecture, such as in residential buildings, universities and student accommodation, is an ideal way of creating new – and hopefully better – societies based on a foundation of religious values
Model structure for protocol adherence utilizing a manualized therapeutic massage intervention
Authors: Larson Erika R. , Kinkead Becky , Edwards Sherry A. , Schettler Pamela J. , Dunlop Boadie W. , Rakofsky Jeffrey J. , Rapaport Mark H.
Published: October 2018

Background

The Protocol Training and Assessment Model (Model) was developed through collaboration between Emory University School of Medicine and Atlanta School of Massage to minimize intra- and inter-therapist variability for two research massage therapist (rMT) applied intervention arms in the Massage for Cancer-Related Fatigue (MCRF) early-phase study. The Model was followed to maintain and assess protocol integrity for the study’s manualized Swedish massage therapy (SMT) and light touch (LT) interventions.

Methods

The Model includes initial rMT training, quarterly retraining sessions, accessible resources (scripts, treatment guides, weekly research personnel meetings), and ongoing monitoring. Model efficacy was assessed by monitoring data collected at retraining sessions, through audio recording review, and through subject and rMT reporting.

Results

Model application resulted in a high level of intervention consistency throughout the study. Protocol-related session comment rate by subjects was 2.7%. Few study participants reported intra-rMT or inter-rMT treatment delivery differences. Observation during retraining sessions indicated massage therapists continued to adhere to protocols. Importantly rMTs increased their participation beyond core duties, suggesting additional ways to standardize subject treatment experience.

Conclusions

Through systematic application of the Protocol Training and Assessment Model, continuous and collaborative quality improvement discussions between scientists and research massage therapists resulted in reliable, standardized SMT and LT interventions for the MCRF early-phase study. Future research can apply the Model to support and assess consistent rMT-delivered intervention applications.
Decreased anxiety after Dawood fasting in the pre-elderly and elderly
Authors: Fidianingsih Ika , Jamil Nur Aisyah , Andriani Russy Novita , Rindra Wira Muhammad
Published: October 2018

Background

A high prevalence of anxiety in the elderly often leads to decreased quality of life (QOL). A restrictive diet can increase the production of ketone bodies that encourage mood enhancement, neural protection and pain reduction. This study aimed to identify whether Dawood fasting could increase the QOL of the elderly by reducing anxiety.

Methods

This research was a quasi-experimental study involving a pretest–post-test control group design. The subjects were pre-elderly and elderly or healthy people aged more than 50, and a consecutive sampling method was employed. The fasting group observed the fast of Dawood, in which they abstained from eating, drinking, or having sexual intercourse from the break of dawn to dusk with the expressed intent to fast every other day. The fast was observed for 22 days (11 fasting days). Anxiety was examined using the Hamilton Rating Scale for Anxiety (HRS-A), while QOL was identified using the Indonesian version of the World Health Organisation Quality of Life (WHOQOL).

Results

A total of 48 respondents participated in this study with 24 respondents observing the fast of Dawood and 24 others not fasting. Results showed that the 22 days of Dawood fast reduced respondents’ complaints about anxiety by 4.37% and was significantly different from the non-fasting group (p=0.001). There was an increase in the QOL of the fasting group (p=0.019), although no significant difference was found when compared to the non-fasting group.

Conclusions

The fast of Dawood reduced anxiety in the pre-elderly and elderly.
Music to reduce pain and anxiety in cystoscopy: a systematic review and meta-analysis
Authors: García-Perdomo Herney Andrés , Montealegre Cardona Laura M. , Cordoba-Wagner Maria Juliana , Zapata-Copete James A.
Published: October 2018

Background

To assess the effectiveness and harms of music to reduce anxiety and pain in cystoscopy.

Methods

We searched MEDLINE (OVID), EMBASE, LILACS and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception to nowadays. We included clinical trials, involving the assessment of the effect of music in cystoscopy. The primary outcomes were pain and anxiety measured by any scale and the secondary outcomes were length of stay, physiological parameters (blood pressure or heart rate) and adverse effects. Cochrane Collaboration tool was used to assess the risk of bias. We performed the statistical analysis in R and reported information about mean difference (MD) with 95% CI. Heterogeneity was evaluated using the I2 test.

Results

We included six studies in our qualitative and quantitative analysis. Five studies used a flexible cystoscope and the other one performed the procedure with a rigid cystoscope. Music was played during the procedure in five studies, while the other was before it. All studies compared music vs. no intervention. Almost all items were assessed as low risk of bias; however, the allocation concealment was unclear in all the studies. We found a MD of −1.33 (95% CI −2.45 to −0.21) (I2=97.2%) favoring music for pain and a MD of −8.42 (95% CI −15.02, −1.82) (I2=99.6%) was found, favoring music for anxiety.

Conclusions

Playing music might be an effective intervention that lowers pain and anxiety in patients who undergo cystoscopy.
Ten forms of recognition and misrecognition in long-term care for older people
Authors: Laitinen Arto , Pirhonen Jari
Published: October 2018

During recent decades, theories of mutual recognition have been intensively debated in social philosophy. According to one of the main theorists in the field, Axel Honneth, the entire social world may be based on interpersonal recognition (such as mutual respect, esteem and care). Our aim is to study what it would take that residents in long-term care would become adequately interpersonally recognized. We also examine who could be seen as bearing the responsibility for providing such recognition. In this paper, we distinguish ten aspects of recognition. We suggest that in order to support residents’ dignity, long-term care should be arranged in a way that preserves residents’ full personhood regardless of their cognitive or other abilities: the mere fact that they are human persons is a ground for recognition as a person. But further, in good care residents’ personal characteristics and residents’ ties to significant others are also recognized to enable them to feel loved, esteemed and respected.
Monitoring of Particle Crushing under One-Dimensional Loading
Authors: Li Bo , Chen Liangliang , Wang Jun , Zeng Xiangwu
Published: October 2018

A modified one-dimensional testing apparatus that incorporates a bender–extender element system and tactile pressure sensors was developed for the monitoring of particle crushing. The apparatus was tested using five types of glass beads with different particle sizes. The compressional shear wave velocities and their ratio were evaluated with respect to the porosity to establish the microstructural evolution of the granular material. The results showed that the bender–extender element system functioned excellently under high-pressure one-dimensional compression, with the shear wave velocity ratio increasing with increasing loading stress up to 7 MPa and thereafter decreasing. The loading stress of 7 MPa was thus considered the breakage stress of the glass beads, as also reflected by a sharp increase in strain. The glass beads subsequently entered Stage 2 of the crushing process, characterized by significant crushing. Arching of the particle assembly was also clearly observed, and this was enhanced by an increase in the roughness of the side plates of the container. An empirical equation for evaluating the arching was derived. The microstructural evolution and macro behavior of the glass beads under the constrained boundary condition and high compression pressure were found to be analogous to those of the crushing of high-porosity sandstone.
Behaviors of New RC Bridge Columns Made of Highly Flowable Strain-Hardening Fiber-Reinforced Concrete (HF-SHFRC) under Cyclic Loads
Authors: Liao Wen-Cheng , Liu Kuang-Yen , Yeh Chih-Chiang
Published: October 2018

Remarkable development of high-strength concrete and reinforcement has been achieved nowadays. The purpose of the New Reinforced Concrete (New RC) project is aimed to reduce member section size by using high-strength concrete (f′c > 70 MPa) and high-strength rebars (fy > 685 MPa). Material consumption can be further reduced owing to the upgrade of strength. However, the brittle nature of high-strength concrete may also cause early cover spalling and other ductility issues. The addition of steel fibers is an alternative transverse reinforcement in New RC infrastructure systems. Highly flowable strain-hardening fiber-reinforced concrete (HF-SHFRC) has excellent workability in the fresh state and exhibits the strain-hardening and multiple-cracking characteristics of high-performance fiber-reinforced cementitious composites (HPFRCC) in their hardened state. This study aims to investigate the cyclic behavior of New RC bridge columns made of HF-SHFRC. Five large-scale bridge columns are subjected to cyclic lateral loading to verify their responses and deformation capacity. The test results show that by adding 1.5 % of high-strength hooked steel fibers, great deformation capacity is developed, in which either the stirrups spacing is increased to two times that of the control specimen or all tires are eliminated in New RC bridge columns. In addition, the accuracy of the proposed concept of equivalent lateral reinforcement is verified by the test results. Implementation of HF-SHFRC in New RC infrastructure offers opportunities to significantly simplify the design and construction of members for sustainable urbanization while ensuring adequate ductility and damage tolerance.
MANAGEMENT OF ENDOCRINE DISEASE: Transition of care for young adult patients with Turner syndrome
Authors: Bernard Valérie , Donadille Bruno , Le Poulennec Tiphaine , Nedelcu Mariana , Martinerie Laetitia , Christin-Maitre Sophie
Published: October 2018

Turner syndrome (TS), affecting 1/2000 to 1/2500 live born girls, is a chromosomal aberration with a total or partial loss of one of the X chromosomes. The diagnosis can be established from the intra-uterine life to adulthood. TS is a chronic disease with particular morbidity and mortality. The loss to follow-up rate, during transition, between children and adult units, remains a crucial issue. This review focusses on the adolescent and young adult patients with TS. The different goals of TS transition are presented as well as some of the tools available in order to improve this transition. The involvement of the patient’s family, advocacy groups and therapeutic educational programs are discussed. A specificity concerning TS transition, as compared to other chronic diseases, relies on the fact that patients with TS may present a peculiar neurocognitive profile. They are in general more anxious than the general population. Therefore, psychological support should be offered to optimize transition. Data illustrating the beneficial impact of an organised transition of TS, from paediatric units to multidisciplinary adult care systems, within the same reference centre are presented. Further studies are required to evaluate the mid-to-long-term transition of paediatric patients with TS referred to adult units.
Gap Junctions and NCA Cation Channels Are Critical for Developmentally Timed Sleep and Arousal in Caenorhabditis elegans
Authors: Huang Huiyan , Hayden Dustin J , Zhu Chen-Tseh , Bennett Heather L , Venkatachalam Vivek , Skuja Lukas L , Hart Anne C
Published: October 2018

The molecular mechanisms of sleep are not fully understood. Huang et al. demonstrate that loss of Caenorhabditis elegans UNC-7 or UNC-9 innexins dramatically reduces sleep during L4/A lethargus and that those innexins are partially required...

An essential characteristic of sleep is heightened arousal threshold, with decreased behavioral response to external stimuli. The molecular and cellular mechanisms underlying arousal threshold changes during sleep are not fully understood. We report that loss of UNC-7 or UNC-9 innexin function dramatically reduced sleep and decreased arousal threshold during developmentally timed sleep in Caenorhabditis  elegans. UNC-7 function was required in premotor interneurons and UNC-9 function was required in motor neurons in this paradigm. Simultaneous transient overexpression of UNC-7 and UNC-9 was sufficient to induce anachronistic sleep in adult animals. Moreover, loss of UNC-7 or UNC-9 suppressed the increased sleep of EGL-4 gain-of-function animals, which have increased cyclic-GMP–dependent protein kinase activity. These results suggest C. elegans gap junctions may act downstream of previously identified sleep regulators. In other paradigms, the NCA cation channels act upstream of gap junctions. Consistent with this, diminished NCA channel activity in C. elegans robustly increased arousal thresholds during sleep bouts in L4-to-adult developmentally timed sleep. Total time in sleep bouts was only modestly increased in animals lacking NCA channel auxiliary subunit UNC-79, whereas increased channel activity dramatically decreased sleep. Loss of EGL-4 or innexin proteins suppressed UNC-79 loss-of-function sleep and arousal defects. In Drosophila, the ion channel narrow abdomen, an ortholog of the C. elegans NCA channels, drive the pigment dispersing factor (PDF) neuropeptide release, regulating circadian behavior. However, in C. elegans, we found that loss of the PDF receptor PDFR-1 did not suppress gain-of-function sleep defects, suggesting an alternative downstream pathway. This study emphasizes the conservation and importance of neuronal activity modulation during sleep, and unequivocally demonstrates that gap junction function is critical for normal sleep.
A COMPARATIVE ASSESSMENT OF SEMEN QUALITY IN SMOKERS AND NON-SMOKERS INCLUDING SPERM BPDE-DNA ADDUCT FORMATION AND ACROSOME STATUS
Authors: Saha Rinku , Roychoudhury Shubhadeep , Kumar Kar Kushal , C. Varghese Alex , Nandi4 Parag , Mitra Sreyashi , Murmu Nabendu , Massanyi Peter , Kolesarova Adriana
Published: October 2018

The objective of the present study was to investigate semen quality of infertile smokers and non-smokers including Benzo[a]Pyrene-7,8-diol-9,10 epoxide (BPDE)-DNA adduct formation and acrosome status of sperm cells. Semen quality parameters were analyzed according to 2010 World Health Organization criteria in 122 non-smokers and 125 cigarette smokers attending tertiary health care centre in Barak Valley of Assam, India followed by BPDE-DNA adduct formation and acrosome status test. A significant decline was found in sperm concentration, progressive motility, morphology in smokers (p
EXTRACTION OF POLYSACCHARIDES FROM OPUNTIA CACTUS FOR ITS POTENTIAL APPLICATION IN EDIBLE COATING TO IMPROVE THE SHELF LIFE OF CITRUS (KINNOW MANDARIN) FRUIT
Authors: Riaz Sara , Tauseef Sultan M. , Sibt-e-Abass Muhammad , Imran Muhammad , Shabir Ahmad Rabia , Bilal Hussain Muhammad , Ali Shariati Mohammad , Sergeevna Kosenko Inna , Leonidovna Kleymenova Natalia , Nikolaevna Egorova Galina
Published: October 2018

Fruits and vegetables are subjected to post-harvest losses due to high moisture contents along with other physiological factors. Among various measure to control loses, development of edible coatings has been an imperative and innovative technique to achieve the desired goal. Opuntia cactus, a xerotrophyte, plant contains appreciable amount of polysaccharides thus can be utilized in edible coating formation. The mandate of present study was to extract polysaccharides from cactus for development of edible coatings for their potential applications on citrus fruits. For the purpose, various concentrations of extracted cactus polysaccharides were used to develop edible coatings. These coating were applied on citrus fruits (Kinnow mandarin) which were then stored for period of 35 days. The results indicated that the maximum moisture was observed in T3 (2% cactus polysaccharides) i.e. 86.94±2.10%. The maximum value for pH of coated citrus was found in T1 (3.19% cactus polysaccharides) as 3.19±0.02%. Conclusively, as the demand of fresh looking fruits and vegetables is increasing due to the awareness among the masses, edible coatings using cactus polysaccharides can play an imperative role in increasing the shelf life along with retaining the quality of various commodities.
INFLUENCE OF PARTIALLY HYDROLYZED GUAR GUM AS SOLUBLE FIBER ON PHYSICOCHEMICAL, TEXTURAL AND SENSORY CHARACTERISTICS OF YOGHURT
Authors: Mudgil Deepak
Published: October 2018

The effect of partially hydrolyzed guar gum fortification on physicochemical, textural and sensory characteristics of yoghurt was investigated. Fiber fortification was done at 1-5% levels to study the effect of soluble fiber fortification on the quality of yoghurt. Fiber addition significantly influenced the textural characteristics of yoghurt such as hardness, adhesiveness, cohesiveness, springiness and gumminess (p
INHIBITORY EFFECT OF ESSENTIAL OILS FROM SOME LAMIACEAE SPECIES ON GROWTH OF EUROTIUM SPP. ISOLATED FROM BREAD
Authors: Císarová Miroslava , Hleba LukÃ¡Å¡ , Tančinová Dana , Florková MÃ¡ria , Foltinová Denisa , Charousová Ivana , Vrbová KristÃ­na , Božik MatÄj , Klouček Pavel
Published: October 2018

Bread is considered an intermediate - moisture food product that is prone to mould spoilage. Growth of spoilage fungi is currently controlled with the addition of chemical preservatives. Consumers demand more natural products and there is a need to reduce the amount of chemical preservatives added to foods. Essential oils (EOs) and their constituents emerged as promising and effective compounds to protect foods from lipid peroxidation and provide microbiological food safety. So the aim of our study was to determinate microscopic fungi involved in contamination of bread target the genus Eurotium and to evaluate the antifungal activity of 5 EOs by vapor contact against the fungal species of this genus. In all samples after three days of cultivation fungi created colonies on the surface of the crust and the pieces of the bread samples stored on DRBC were after three days of cultivation covered with fungi colonies. Altogether 195 isolates were recovered from 8 bread samples and assigned to 10 fungal genera. The most frequently genus of fungi was Penicillium, Aspergillus, Cladosporium, Epicoccum and Eurotium. Based on phylogenetic and morphological studies, five different Eurotium species were identified: E. amstelodami, E. chevalieri, E. herbariorum, E. rubrum and E. repens. In this study, we explored the potential of five essential oils retrieved from some Lamiaceae species, concretely: basil (Ocinum basilicum L.), lavender (Lavandula angustifolia Mill.), oregano (Origanum vulgare L.), mint (Metha piperita L.) and sage (Salvia officinalis L.). Gas chromatography–mass spectrometry (GC-MS) analysis allowed for the identification of 28 compounds as main constituents. Inhibitory activity of EOs was assessed against 5 species of genus Eurotium (2 isolates for each specie). In all studied strains, the essential oils caused significant differences (Pbasil (with the best Mycelial growth Inhibition (MGI) 93.65% to E. herbariorum) and the low effect had sage essential oil (with the best MGI 68.62% to E. repens). The present study demonstrated the potential food preservative ability of essential oils from some Lamiaceae species.
Acute kidney injury and other factors associated with mortality in hiv-infected patients
Authors: Silva Junior Geraldo Bezerra da , Parente Filho Sérgio Luiz Arruda , Soares Douglas de Sousa , Alencar Rodrigo da Nóbrega de , Peixoto Tiago Tomaz Teles , Nogueira Isadora Sales , Oliveira Filho Antônio Mendes Ponte de , Menezes Fernanda Holanda , Cavalcante Malena Gadelha , Pires Neto Roberto da Justa , Daher Elizabeth de Francesco
Published: October 2018

SUMMARY OBJECTIVE: HIV-related mortality is still high, especially in developed countries. The aim of this study is to investigate factors associated to death in HIV-infected patients. METHODS: This is a cross-sectional study with all HIV adult patients admitted to a tertiary infectious diseases hospital in Fortaleza, Northeast Brazil, from January 2013 to December 2014. Patients were divided into two groups: survivors and non-survivors. Demo-graphical, clinical and laboratory data were compared and a logistic regression was performed in order to investigate risk factors for death. P values ≤0.05 were considered statistically significant. RESULTS: A total of 200 patients with mean age of 39 years were including in the study, 69.5% males. Fifteen patients (7.5%) died. Non-survivors presented a higher percentage of males (93.3 vs. 67.3%, p = 0.037). Non-survivors presented AKI (73.3 vs. 10.3%, p < 0.001), liver dysfunction (33.3 vs. 11.5, p = 0.031), dyspnea (73.3 vs. 33.0%, p = 0.002) and disorientation (33.3 vs. 12.4%, p = 0.025) more frequently. Non-survivors also had higher levels of urea (73.8 ± 52.7vs. 36.1 ± 29.1 mg/dL, p < 0.001), creatinine (1.98 ± 1.65 vs. 1.05 ± 1.07 mg/dL, p < 0.001), aspartate aminotransferase (130.8 vs. 84.8 U/L, p = 0.03), alanine aminotransferase (115.6 vs. 85.4 U/L, p = 0.045) and lactate dehydrogenase (LDH) (1208 vs. 608 U/L, p = 0.012), as well as lower levels of bicarbonate (18.0 ± 4.7 vs. 21.6 ± 4.6 mEq/L, p = 0.016) and PCO2 (27.8 ± 7.7 vs. 33.0 ± 9.3 mmHg, p = 0.05). In multivariate analysis, disorientation (p = 0.035, OR = 5.523, 95%CI = 1.130 – 26.998), dyspnoea (p = 0.046, OR = 4.064, 95%CI = 1.028 – 16.073), AKI (p < 0.001, OR = 18.045, 95%CI = 4.308 – 75.596) and disseminated histoplasmosis (p = 0.016, OR = 12.696, 95%CI = 1.618 – 99.646) and LDH > 1000 U/L (p = 0.038, OR = 4.854, 95%CI = 1.093 – 21.739) were risk factors for death.]CONCLUSION: AKI and disseminated histoplasmosis (DH) were the main risk factors for death in the studied population. Neurologic and respiratory impairment as well as higher levels of LDH also increased mortality in HIV-infected patients.
Contexto nacional e as exigências para a pesquisa em educação
Authors: Paludo Conceição
Published: October 2018

RESUMO Neste artigo, tendo como apoio estudos e pesquisas que venho realizando, assim como revisão bibliográfica, pretendo contribuir para a análise da atualidade brasileira e pontuar alguns desafios para a pesquisa em educação. O que se realiza a partir da perspectiva teórico-metodológica do materialismo histórico-dialético. Conclui-se que alguns dos desafios centrais para o pesquisador, notadamente na grande área das ciências humanas, na qual se inclui a educação, são: revisão do referencial teórico e metodológico; a necessidade de debruçar-se sobre a teoria, revendo conceitos e categorias fundamentais para a análise da realidade; assumir a perspectiva da defesa radical da sociedade; articular-se em redes; aproximar-se dos extratos populares; denunciar retrocessos e anunciar possibilidades. Enfim, assumir a dimensão política do pensar e fazer pesquisas.
Suction caisson foundations for offshore wind energy: cyclic response in sand and sand over clay
Authors: Zhu Fang Yuan , Bienen Britta , O'Loughlin Conleth , Cassidy Mark Jason , Morgan Neil
Published: October 2018

This technical note considers experimental data on the long-term response of a suction caisson in sand and sand over clay to lateral cyclic loading. Installation of the caisson under suction in a geotechnical centrifuge provides insight into the contribution of this installation process, as well as the effects that soil drainage and consolidation in the clay layer have on the accumulated caisson rotation and change in stiffness. The tests focused on sand over clay, and considered variations in the cyclic load magnitude and symmetry. One-way cyclic loading in sand over clay is seen to result in higher rotation than two-way loading, which contrasts with findings from previous studies in sand. Excess pore pressure dissipation in the clay layer leads to strength increases that stabilise caisson rotation and increase stiffness. The rate of accumulation in caisson rotation is observed to be the same from centrifuge and single gravity tests, while the initial rotation differs with stress level, drainage regime, loading magnitude, soil profile and installation method. The centrifuge tests are considered collectively with equivalent single gravity tests to form a basis for predicting the long-term response of a monopod suction caisson.
CORPORATE SUSTAINABILITY PERFORMANCE MEASUREMENT: AN APPLICATION ON HOME APPLIANCE FIRM
Authors: SOFYALIOĞLU Çiğdem , SÜRÜCÜ Ebru
Published: October 2018

Firms that want to create long-term value can use corporate
sustainability as a business approach while preventing risks that arise from the company's
decision-making activities with unifying management standards and economic,
environmental and social factors. Corporate sustainability performance
measurement ensures the examination of sustainability's three dimensions, which
are social, environmental and economic, on a corporate level. However, when
assessing corporate sustainability performance, using too many criteria poses a
problem because it is difficult to set all the criteria for a master criterion.
Using multi-criteria decision-making (MCDM) modeling is an applicable approach
to measure corporate sustainability. In this study, AHP (Analytic Hierarchy Process),
which is one of the multi-criteria decision-making modelings, is used for weighting sustainability's three dimensions
and three dimensions' sub-factors. Later, TOPSIS (Technical Order of Similarity
to Ideal Solution) method was used to measure the supply chain sustainability
performance of one of the white goods companies known and recognized in Turkey.
The data are derived from the annual and sustainability reports of the
well-known household appliances brand between 2010 and 2015. This study aimed to show that AHP and TOPSIS
can be used in MCDM methods while
measuring sustainability performance. The article ends with constraints of the
study and future work ideas.
Comparison of Perceptions of Service Quality in Transport Systems within the Context of Users of Istanbul City's Metro and Metrobus Public Transportation Systems
Authors: CERAN Esin Bengü , ÇAKIR ESEN Tuba Ezgi
Published: October 2018

The quality of service
is defined as the degree of conformity of the service offered for the intended
purpose. The SERVQUAL Model, which has been developed on the basis of the
difficulty in definition and performance measurement of the quality of service,
is the most frequently used model for service quality measurement.This study aims to
measure the users' perceptions of service quality of metro and metrobus, which
are among the most frequently used transportation systems in Istanbul, and to
investigate differences in service quality perceptions in terms of the
demographic characteristics of the participants (age, gender, income level,
education status, employment status, marital status), intended use of the these
transportation systems and the type of tickets used.Within the scope of the
research, service quality perceptions of metro and metrobus users were analyzed
using the SERVQUAL scale adapted to transportation services, and the results
were evaluated in this regard.