bluuebunny/crossref_metadata_2025 huggingface dataset:
From podium to press: The 10-year publication rate of abstracts presented at the annual meetings of the Quebec Urological Association (QUA)
Authors: Al-Qaoud Talal M. , Yafi Faysal A. , Aprikian Armen G.
Published: November 2013

Introduction: Our objective was to determine the proportion of publications arising from abstracts presented at the Quebec Urological Association (QUA). We wanted to analyze differences in publication rates according to certain parameters, and to examine the quality of publications using journal impact factors.Methods: All abstracts presented at the annual meetings of the QUA between 2000 and 2010 were obtained from the QUA archives and searched using the PubMed database. Variables included: institute, number of abstracts presented, year of presentation and publication, impact factor of publishing journal (according to 2010 Thomson Reuters report), time to publication (months), research type, presenter and location of research. Kaplan Meier methods were used for analysis.Results: By May 2012, 248 out of 439 abstracts (QUA 2000 to 2010) were published in peer-reviewed journals, resulting in a publication rate of 56%. There were significant differences in publication rates according to institution, research type and location of research. Researchers from non-Quebec institutions were twice as likely to publish compared to those from Quebec institutions (Cox HR 2.13, CI 1.20-3.76, p < 0.01).Discussion: The QUA publication rate was considerably higher than previously studied by the American Urological Association (37.8%) and British Association of Urological Surgeons (≈42%); however length of follow-up and presentation types differed. Research conducted outside Quebec was more likely to be published, reflecting the multi-institution robust study designs and higher level of evidence. Factors influencing publication deserve further attention, and clinicians are encouraged to conduct research with intent to publish.
Evidence-based guideline recommendations on low-dose rate brachytherapy in patients with low- or intermediate-risk prostate cancer
Authors: Rodrigues George , Yao Xiaomei , Loblaw D. Andrew , Brundage Michael , Chin Joseph L.
Published: November 2013

Objective: The Genitourinary Cancer Disease Site Group (GUDSG) and Cancer Care Ontario’s Program in Evidence-Based Care (PEBC) in Ontario, Canada developed a guideline on low-dose rate brachytherapy (LDR-BT) in patients with early-stage low-grade prostate cancer in 2001. The current updated guideline focuses on the research questions regarding the effect of LDR-BT alone, the effect of LDR-BT with external beam radiation therapy (EBRT) and the selection of an isotope.Methods: This guideline was developed by using the methods of the Practice Guidelines Development Cycle and the core methodology was a systematic review. MEDLINE and EMBASE (from January 1996 to October 2011), the Cochrane Library, main guideline websites, and main annual meeting abstract websites specific for genitourinary diseases were searched. Internal and external reviews of the draft guideline were conducted.Results: The draft guideline was developed according to a total of 10 systematic reviews and 55 full text articles that met the preplanned study selection criteria. The quality of evidence was low to moderate. The final report reflects integration of the feedback obtained through the internal review (two oncologists and a methodologist) and external review (five target reviewers and 48 professional consultation reviewers) process, with final approval given by the GU DSG and the PEBC.Conclusion: The main recommendations are: (1) For patients with newly diagnosed low-risk or intermediate-risk prostate cancer who require or choose active treatment, LDR-BT alone is a treatment option as an alternative to EBRT alone or RP alone; and (2) I-125 and Pd-103 are each reasonable isotope options.
Microscopic examination of normal nail clippings
Authors: Werner Betina , Antunes Andre
Published: November 2013

Background: Nail clipping analysis for diagnosing causes of onychodystrophy other than onychomycosis is investigated to a very small extent. In order to achieve acceptance as a diagnostic method for any kind of nail abnormalities, normal microscopic parameters have to be established first. In most reported cases,  nail plates were fixed in formalin with processing of the specimens with routine automated histotechnique.
Fácies sedimentares da Formação Rio Claro, neocenozóico da depressão periférica paulista
Authors: Melo Mário Sérgio de , Coimbra Armando Márcia , Cuchierato Gláucia
Published: November 2013

Os dados das fácies sedimentares da Formação Rio Claro aqui apresentados resultam de pesquisa enfocando os depósitos neocenozóicos da porção centro-leste da Depressão Periférica Paulista, a qual objetivou a compreensão da evolução geológica da região. Os sedimentos neocenozóicos são delgados e descontínuos, sua interpretação e classificação requereram uma abordagem levando em conta, também, aspectos geomórficos (relações com níveis planálticos), além dos conceitos litoestratigráficos usuais. Foram identificados cinco níveis planálticos de extensão regional, sendo' que os dois mais elevados ocorrem somente nas províncias geomorfológicas do Planalto Atlântico e Cuestas Basálticas (limítrofes com a Depressão Periférica), e os três mais jovens e rebaixados ocorrem dentro dos limites da Depressão Periférica. A associação de depósitos rudáceos e couraças ferruginosas com estes níveis planálticos é sugestiva de que eles correspondam a pediplanos elaborados em fases de climas secos. A Formação Rio Claro foi reconhecida na área do platô de Rio Claro, onde é mais contínua, e na borda leste da Depressão Periférica, com ocorrências descontínuas; ocorre sobre os dois níveis planálticos principais que nivelam as colinas da região; é constituida por depósitos de sistema fluvial meandrante, formados sob clima úmido, agrupados em quatro litofácies principais: lamitos de processos gravitacionais; cascalhos e areias de canais e barras fluviais; areias finas de rompimento de diques marginais; e argilas de transbordamento em planície de inundação. Na área do platô de Rio Claro a sedimentação foi controlada pela reativação neocenozóica de falhas com movimentação vertical na estrutura de Pitanga, alto estrutural ativo durante o Mesozóico, situado a jusante do sítio deposicional. Nas ocorrências da borda leste da Depressão Periférica, a sedimentação está mais claramente associada com barramentos litológicos da drenagem (soleiras e diques de diabásio)
Armando Márcio Coimbra (1949 -1998)
Authors: Modenesi May Christine
Published: November 2013

Em 20 de setembro de 1998 faleceu em São Paulo Armando Márcio Coimbra, Professor Titular do Departamento de Paleontologia e Estratigrafia do Instituto de Geociências da Universidade de São Paulo. Cientista ativo, com importante contribuição no campo da Estratigrafia e Sedimentologia, Armando foi antes de tudo um professor dedicado, um líder por vocação, que aglutinava à sua volta alunos e colegas. Seus estudos sobre o Permo-Triássico das bacias do Parnaíba e Paraná, sobre o Cretáceo da Bacia Bauru e o Cenozóico das bacias tafrogênicas do sudeste do Brasil são obras de referência sobre o Fanerozóico brasileiro.
A escala nas ciências atmosféricas
Authors: Nunes Lucí Hidalgo
Published: November 2013

A escala de abordagem é um dos aspectos mais importantes das ciências atmosféricas, definindo numa pesquisa não apenas a área e período de abrangência, mas também as técnicas e os métodos a serem empregados em busca de seus objetivos.
The Effect of Pretreatment with Chemotherapeutic Drugs on the Susceptibility to Lymphokine Activated CD8+ T Lymphocyte-Mediated Cytotoxicity in CMK Leukemia Cells
Authors: Bülent  Özgönenel  , Öner  Özdemir  , Melike  Özgönenel,  , Ronald  Thomas  , Steven  Buck  , Süreyya Savasan
Published: November 2013

Objectives: Certain tumor cells pretreated with chemotherapeutic drugs become more susceptible to death by apoptosis induced by killer cells of the immune system. We examined the CD8+ cytotoxic T lymphocyte (CTL)-mediated cytotoxicity in myeloid leukemia cell lines pretreated with chemotherapeutic drugs.
Methods: Peripheral blood mononuclear cells were expanded in vitro in the presence of phytohemagglutinin-P, interleukins-2 and -15. CD3+ CD8+ cells representing the CTLs were isolated using magnetic immunoselection and used in immune cytotoxicity experiments against K562 and CMK leukemia cells, pretreated with two different concentrations of cytarabine and etoposide.
Results: In CMK cells pretreated with etoposide at 2 M and 20 M concentrations, the mean cell-mediated immune cytotoxicity rose to 21.4 ± 12.9% (p=0.09) and 23.4 ± 12.6% (p=0.046), respectively, when compared to the control value of 6.6 ± 3.8%. In CMK cells pretreated with cytarabine at 1 M and 10M concentrations, the mean immune cytotoxicity rose to 14.3 ± 11.2% and 22.6 ± 15.2%, respectively, compared to the control value of 8.7 ± 6.3%, although these results did not reach statistical significance. However, a similar increase in CTL-mediated immune cytotoxicity was not observed against drug-treated K562 cells.
Conclusion: This study suggests that pretreatment with chemotherapeutic drugs can render CMK leukemia cells more susceptible to immune attack by activated CTLs. Further studies are needed to explore this phenomenon, to establish an immune-enhancing effect of pretreatment with chemotherapy in the treatment of leukemia.
Effects of ocean acidification on the dissolution rates of reef-coral skeletons
Authors: van Woesik Robert , van Woesik Kelly , van Woesik Liana , van Woesik Sandra
Published: November 2013

Ocean acidification threatens the foundation of tropical coral reefs. This study investigated three aspects of ocean acidification: (i) the rates at which perforate and imperforate coral-colony skeletons passively dissolve when pH is 7.8, which is predicted to occur globally by 2100, (ii) the rates of passive dissolution of corals with respect to coral-colony surface areas, and (iii) the comparative rates of a vertical reef-growth model, incorporating passive dissolution rates, and predicted sea-level rise. By 2100, when the ocean pH is expected to be 7.8, perforateMontiporacoral skeletons will lose on average 15 kg CaCO3m−2y−1, which is approximately −10.5 mm of vertical reduction of reef framework per year. This rate of passive dissolution is higher than the average rate of reef growth over the last several millennia and suggests that reefs composed of perforateMontiporacoral skeletons will have trouble keeping up with sea-level rise under ocean acidification. Reefs composed of primarily imperforate coral skeletons will not likely dissolve as rapidly, but our model shows they will also have trouble keeping up with sea-level rise by 2050.
Multi‐Parametric Analysis of Cell Death Pathways Using Live‐Cell Microscopy
Authors: Joshi Gaurav N. , Knecht David A.
Published: November 2013

Programmed cell death is a complex process with new forms being discovered with regularity. Each pathway has a distinct and overlapping biochemical and physiological change occurring as the cell prepares for death. Detection of these changes can be facilitated by the availability of various fluorescent probes and advances in microscope systems. By analyzing these probes over time using fluorescence microscopy, the changes that occur in each cell en route to death can be analyzed on a cell‐by‐cell basis. While the timing of events varies considerably from cell to cell, it has been found that the sequence of events is highly conserved. Transient events, which would be difficult to detect using population averaging techniques, are readily detected when cells are analyzed individually in time lapse. The protocols in this unit describe using probes for real‐time imaging of one of the apoptotic cell death pathways using various inducers, as well as the associated hardware necessary for imaging so that the imaging itself is not affecting cell viability. Curr. Protoc. Toxicol. 58:4.40.1‐4.40.31. © 2013 by John Wiley & Sons, Inc.
Understanding controls on rapid ice‐stream retreat during the last deglaciation of Marguerite Bay, Antarctica, using a numerical model
Authors: Jamieson Stewart S. R. , Vieli Andreas , Cofaigh Colm Ó , Stokes Chris R. , Livingstone Stephen J. , Hillenbrand Claus‐Dieter
Published: November 2013

Using a one‐dimensional numerical model of ice‐stream flow with robust grounding‐line dynamics, we explore controls on paleo‐ice‐stream retreat in Marguerite Bay, Antarctica, during the last deglaciation. Landforms on the continental shelf constrain the numerical model and suggest that retreat was rapid but punctuated by a series of slowdowns. We investigate the sensitivity of ice‐stream retreat to changes in subglacial and lateral topography and to forcing processes including sea‐level rise, enhanced melting beneath an ice shelf, atmospheric warming, and ice‐shelf debuttressing. Our experiments consistently reproduce punctuated retreat on a bed that deepens inland, with retreat‐rate slowdowns controlled by narrowings in the topography. Sensitivity experiments indicate that the magnitudes of change required for individual forcing mechanisms to initiate retreat are unrealistically high but that thresholds are reduced when processes act in combination. The ice stream is, however, most sensitive to ocean warming and associated ice‐shelf melting, and retreat was most likely in response to external forcing that endured throughout the period of retreat rather than to a single triggering “event.” Timescales of retreat are further controlled by the delivery of ice from upstream of the grounding line. Due to the influence of topography, modeled retreat patterns are insensitive to the temporal pattern of forcing evolution. We therefore suggest that despite regionally similar forcing mechanisms, landscape controls significant contrasts in retreat behavior between adjacent but topographically distinct catchments. Patterns of ice‐stream retreat in the past, present, and future should therefore be expected to vary significantly.
How I Started Living a Double Life in Psychological Science
Authors: Magnussen Svein
Published: November 2013

My personal history as an applied cognitive psychology researcher is short, dating 15 years back when I became aware of the field of eyewitness psychology, hitherto neglected in Norway. This short paper describes the development of eyewitness psychology in Norway, which, not accidentally, parallels the development of my own interests in this important field of applied cognitive psychology. Copyright © 2013 John Wiley & Sons, Ltd.
Data‐driven bounded‐error fault detection
Authors: Suárez Fábrega Antonio J. , Bravo Caro José Manuel , Abad Herrera Pedro J. , Gasca Rafael M.
Published: November 2013

In this paper, a new data‐driven fault‐detection method is proposed. This method is based on a new nonparametric system identification approach, which constitutes the principal contribution to this work. The fault‐detection method is a parametric model‐free approach that can be applied to nonlinear systems that work at various operating points. Not only can the fault‐detection process be applied to the steady state of each operating point, but it can also be applied to the transient state resulting from a change in the operating point. In order to detect faults, the proposed method uses an interval predictor based on bounded‐error techniques. The utilization of techniques based on bounded error enables system uncertainties to be included in an explicit way. This in turn leads to the possibility of obtaining interval predictions of the behaviour of the system, which include information on the reliability of the prediction itself. In order to show the effectiveness of the fault‐detection method, two examples are presented: in the form of a simulated process (counter‐flow shell‐and‐tube heat‐exchanger system) and an example of a real application (two‐tanks system). A comparison with two fault‐detection methods has also been included. Copyright © 2013 John Wiley & Sons, Ltd.
Polymer‐Modified Mesoporous Silica Thin Films for Redox‐Mediated Selective Membrane Gating
Authors: Elbert Johannes , Krohm Fabio , Rüttiger Christian , Kienle Sandra , Didzoleit Haiko , Balzer Bizan N. , Hugel Thorsten , Stühn Bernd , Gallei Markus , Brunsen Annette
Published: November 2013

Controlling structure and function to switch ionic transport through synthetic membranes is a major challenge in the fabrication of functional nanodevices. Here we describe the combination of mesoporous silica thin films as structural unit, functionalized with two different redox‐responsive ferrocene‐containing polymers, polyvinylferrocene (PVFc) and poly(2‐(methacryloyloxy)ethyl ferrocenecarboxylate) (PFcMA), by using either a grafting to, or a grafting from approach. Both mesoporous film functionalization strategies are investigated in terms of polymer effect on ionic permselectivity. A significantly different ionic permselective behavior can be observed. This is attributed to different polymer location within the mesoporous film, depending on the functionalization strategies used. Additionally, the influence of chemical oxidation on the ionic permselective behavior is studied by cyclic voltammetry showing a redox‐controlled membrane gating as function of polymer location and the pH value. This study is a first step of combining redox‐responsive ferrocene‐containing polymers and mesoporous membranes, and thus towards redox‐controlled ionic transport through nanopores.
Iron Oxide Nanoparticle and Graphene Nanoribbon Composite as an Anode Material for High‐Performance Li‐Ion Batteries
Authors: Lin Jian , Raji Abdul‐Rahman O. , Nan Kewang , Peng Zhiwei , Yan Zheng , Samuel Errol L. G. , Natelson Douglas , Tour James M.
Published: November 2013

A composite material made of graphene nanoribbons and iron oxide nanoparticles provides a remarkable route to lithium‐ion battery anode with high specific capacity and cycle stability. At a rate of 100 mA/g, the material exhibits a high discharge capacity of ~910 mAh/g after 134 cycles, which is >90% of the theoretical li‐ion storage capacity of iron oxide. Carbon black, carbon nanotubes, and graphene flakes have been employed by researchers to achieve conductivity and stability in lithium‐ion electrode materials. Herein, the use of graphene nanoribbons as a conductive platform on which iron oxide nanoparticles are formed combines the advantages of long carbon nanotubes and flat graphene surfaces. The high capacity over prolonged cycling achieved is due to the synergy between an electrically percolating networks of conductive graphene nanoribbons and the high lithium‐ion storage capability of iron oxide nanoparticles.
CEP57 mutation in a girl with mosaic variegated aneuploidy syndrome
Authors: Pinson Lucile , Mannini Linda , Willems Marjolaine , Cucco Francesco , Sirvent Nicolas , Frebourg Thierry , Quarantotti Valentina , Collet Corinne , Schneider Anouck , Sarda Pierre , Geneviève David , Puechberty Jacques , Lefort Geneviève , Musio Antonio
Published: November 2013

Mosaic variegated aneuploidy (MVA) is a rare autosomal recessive disorder characterized by constitutional aneuploidies. Mutations in BUB1B and CEP57 genes, which are involved in mitotic spindle and microtubule stabilization, respectively, are responsible for a subset of patients with MVA. To date, CEP57 mutations have been reported only in four probands. We report on a girl with this disorder due to c.915‐925dup11 mutation in CEP57, which predicts p.Leu309ProfsX9 and review the literature in order to facilitate genotype–phenotype correlation. Rhizomelic shortening of the upper limbs, skull anomalies with conserved head circumference, and absence of tumor development could be features suggesting a need for molecular screening of the CEP57 gene in patients with this disorder. © 2013 Wiley Periodicals, Inc.
Risk of nonsyndromic cleft lip and palate in relatives of women with breast cancer
Authors: Martelli Daniella Reis Barbosa , Vieira Alexandre R. , Fonseca Aline Tavares , Coletta Ricardo D. , Soares Priscila B. Miranda , Martelli‐Júnior Hercílio
Published: November 2013

© 2013 Wiley Periodicals, Inc.
A novel germline PIGA mutation in Ferro‐Cerebro‐Cutaneous syndrome: A neurodegenerative X‐linked epileptic encephalopathy with systemic iron‐overload
Authors: Swoboda Kathryn J. , Margraf Rebecca L. , Carey John C. , Zhou Holly , Newcomb Tara M. , Coonrod Emily , Durtschi Jacob , Mallempati Kalyan , Kumanovics Attila , Katz Ben E. , Voelkerding Karl V. , Opitz John M.
Published: November 2013

Three related males presented with a newly recognized x‐linked syndrome associated with neurodegeneration, cutaneous abnormalities, and systemic iron overload. Linkage studies demonstrated that they shared a haplotype on Xp21.3–Xp22.2 and exome sequencing was used to identify candidate variants. Of the segregating variants, only a PIGA mutation segregated with disease in the family. The c.328_330delCCT PIGA variant predicts, p.Leu110del (or c.1030_1032delCTT, p.Leu344del depending on the reference sequence). The unaffected great‐grandfather shared his X allele with the proband but he did not have the PIGA mutation, indicating that the mutation arose de novo in his daughter. A single family with a germline PIGA mutation has been reported; affected males had a phenotype characterized by multiple congenital anomalies and severe neurologic impairment resulting in infantile lethality. In contrast, affected boys in the family described here were born without anomalies and were neurologically normal prior to onset of seizures after 6 months of age, with two surviving to the second decade. PIGA encodes an enzyme in the GPI anchor biosynthesis pathway. An affected individual in the family studied here was deficient in GPI anchor proteins on granulocytes but not erythrocytes. In conclusion, the PIGA mutation in this family likely causes a reduction in GPI anchor protein cell surface expression in various cell types, resulting in the observed pleiotropic phenotype involving central nervous system, skin, and iron metabolism. © 2013 Wiley Periodicals, Inc.
Characterization of core clinical phenotypes associated with recurrent proximal 15q25.2 microdeletions
Authors: Burgess Trent , Brown Natasha J. , Stark Zornitza , Bruno Damien L. , Oertel Ralph , Chong Belinda , Calabro Vanessa , Kornberg Andrew , Sanderson Christine , Kelly Julian , Howell Katherine B. , Savarirayan Ravi , Hinds Rupert , Greenway Anthea , Slater Howard R. , White Susan M.
Published: November 2013

A recurrent proximal microdeletion at 15q25.2 with an approximate 1.5 megabase smallest region of overlap has recently been reported in seven patients and is proposed to be associated with congenital diaphragmatic hernia (CDH), mild to moderate cognitive deficit, and/or features consistent with Diamond–Blackfan anemia. We report on four further patients and define the core phenotypic features of individuals with this microdeletion to include mild to moderate developmental delay or intellectual disability, postnatal short stature, anemia, and cryptorchidism in males. CDH and structural organ malformations appear to be less frequent associations, as is venous thrombosis. There is no consistent facial dysmorphism. Features novel to our patient group include dextrocardia, obstructive sleep apnea, and cleft lip. © 2013 Wiley Periodicals, Inc.
Neurochemical evaluation of brain function with 1H magnetic resonance spectroscopy in patients with fragile X syndrome
Authors: Utine G.E. , Akpınar B. , Arslan U. , Kiper P.Ö.Ş. , Volkan‐Salancı B. , Alanay Y. , Aktaş D. , Haliloğlu G. , Oğuz K.K. , Boduroğlu K. , Alikaşifoğlu M.
Published: November 2013

Fragile X syndrome (FXS) is the most common hereditary disorder of intellectual disability. Cognitive deficits involve executive function, attention, learning and memory. Advanced neuroimaging techniques are available, and 1H magnetic resonance spectroscopy (MRS) can be used as a complementary method to MR imaging to understand disease processes in brain, by in vivo demonstration of brain metabolites. MRS was performed in 13 male patients with FXS full mutation, and 13 age‐ and sex‐matched healthy controls. FXS diagnosis was based on clinical evaluation, followed by detection of FMR1 full mutation. Axial T2 TSE, sagittal T1 SE and coronal 3D MPRAGE images were obtained for both morphological imaging and voxel localization. Following evaluation of conventional images, multivoxel MRS (CSI) through supraventricular white matter and single voxel MRS (svs) with an intermediate echo time (TE:135 ms) from the cerebellar vermis were performed. Choline/Creatine (Cho/Cr), N‐acetyl aspartate/Creatine (NAA/Cr), and Choline/N‐acetyl aspartate (Cho/NAA) ratios were examined at right frontal (RF), left frontal (LF), right parietal (RP), left parietal (LP), and cerebellar vermian (C) white matter. Statistical analyses were done using t‐test and Mann–Whitney U tests. A statistically significant difference was observed in RP Cho/NAA ratio (cell membrane marker/neuroaxonal marker), FXS patients having lower levels than controls (P = 0.016). The results should be evaluated cautiously in parallel to consequences in brain metabolism leading to alterations in neurotransmitter levels, osmoregulation, energy metabolism and oxidative stress response described in animal models. MRS may serve to define a metabolic signature and biomarkers associated with FXS. © 2013 Wiley Periodicals, Inc.
A new case of a LUMBAR syndrome
Authors: Golabi Mahin , An Andrew C. , Lopez Christina , Lee Lauren , Kwong Michael , Hall Bryan D.
Published: November 2013

LUMBAR syndrome (lower body congenital infantile hemangiomas and other skin defects; urogenital anomalies and ulceration; myelopathy; bony deformities; anorectal malformations and arterial anomalies; and rectal anomalies) is a rare association between infantile hemangiomas of the lower half of the body and regional congenital anomalies. Since 1986, 53 cases have been reported and no etiology has been identified. We report on the 54th case in a male infant and review the literature concerning the manifestations of the LUMBAR syndrome. © 2013 Wiley Periodicals, Inc.
A clinical study of patients with pericentromeric deletion and duplication within 16p12.2–p11.2
Authors: Okamoto Nobuhiko , Fujii Tatsuya , Tanaka Junko , Saito Kazumasa , Matsui Takeshi , Harada Naoki
Published: November 2013

The short arm of chromosome 16 is rich in segmental duplications that result in chromosomal rearrangements through non‐allelic homologous recombination. Several syndromes resulting from microdeletions or microduplications in this region have been reported. The chromosome 16p12.2–p11.2 deletion syndrome, 7.1‐ to 8.7‐Mb [OMIM#613604] is characterized by minor facial anomalies, feeding difficulties, a significant delay in speech development, and recurrent ear infections. Reciprocal duplications of 16p12.2–p11.2 have been reported in some patients with autism. We identified a patient with a 16p12.2–p11.2 deletion and a patient with a 16p12.2–p11.2 duplication using oligonucleotide SNP array. The patient with the deletion showed severe developmental delay without autism. The patient with the deletion shared clinical features with previously reported patients. The patient with the duplication showed mild developmental delay and autism. She had dysmorphic features including a round face, a large mouth, and relative macrocephaly. We reviewed the reports of the two syndromes and compared the clinical manifestations. The 16p12.2–p11.2 duplication syndrome is a new syndrome with autism spectral disorders and dysmorphic features. © 2013 Wiley Periodicals, Inc.
Aryne Cycloaddition with Stable Münchnones: Synthesis of 9,10‐Dihydro‐9,10‐epiminoanthracenes and Isoindoles
Authors: Fang Yuesi , Larock Richard C. , Shi Feng
Published: November 2013

Arynes react with stable münchnones in a [3+2] cycloaddition/[4+2] cycloreversion sequence under mild conditions. The reaction initially affords isoindoles, but in the presence of excess arynes, these isoindole intermediates readily undergo a further aryne [4+2] cycloaddition to afford 9,10‐dihydro‐9,10‐epiminoanthracenes in good to excellent yields. Controlling the reaction conditions to stop at the isoindole stage was attempted but proved difficult and limited. This chemistry further expands aryne dipolar cycloaddition chemistry with mesoionic substrates.
Controlled Trifluoromethylation Reactions of Alkynes through Visible‐Light Photoredox Catalysis
Authors: Iqbal Naeem , Jung Jaehun , Park Sehyun , Cho Eun Jin
Published: November 2013

The control of a reaction that can form multiple products is a highly attractive and challenging concept in synthetic chemistry. A set of valuable CF3‐containing molecules, namely trifluoromethylated alkenyl iodides, alkenes, and alkynes, were selectively generated from alkynes and CF3I by environmentally benign and efficient visible‐light photoredox catalysis. Subtle differences in the combination of catalyst, base, and solvent enabled the control of reactivity and selectivity for the reaction between an alkyne and CF3I.
Microstructure and properties of novel fluorescent pyrene functionalized PANI/P(VDF‐HFP) blend
Authors: Singh Veer Pal , Ramani Ramasubbu , Pal Vijay , Prakash Asit , Alam Sarfaraz
Published: November 2013

We herein report the preparation and properties of the first polymer blend using pyrene functionalized polyaniline (pf‐PANI). The pf‐PANI has been synthesized and its blend has been prepared with the copolymer of vinylidene fluoride and hexafluoropropylene P(VDF‐HFP). The FTIR results reveal intermolecular interaction between the polar amide group of pf‐PANI and the polarized CH2 group of P(VDF‐HFP). The crystalline phase of PVDF of the copolymer revealed a transformation from α to β crystalline form after blending with pf‐PANI, as found from FTIR and XRD measurements. The calorimetric measurements together with DMA results revealed the blend is partially miscible. The SEM measurements showed that the pf‐PANI has been dispersed uniformly in the P(VDF‐HFP) matrix. The solution photoluminescence spectrum of the pf‐PANI exhibited emission in the purple–blue region and is slightly red shifted for the blend. The possible applications of this flexible fluorescent pf‐PANI/P(VDF‐HFP) has been suggested. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40162.
Detecting the historical roots of research fields by reference publication year spectroscopy (RPYS)
Authors: Marx Werner , Bornmann Lutz , Barth Andreas , Leydesdorff Loet
Published: November 2013

We introduce the quantitative method named “Reference Publication Year Spectroscopy” (RPYS). With this method one can determine the historical roots of research fields and quantify their impact on current research. RPYS is based on the analysis of the frequency with which references are cited in the publications of a specific research field in terms of the publication years of these cited references. The origins show up in the form of more or less pronounced peaks mostly caused by individual publications that are cited particularly frequently. In this study, we use research on graphene and on solar cells to illustrate how RPYS functions, and what results it can deliver.
Three Cobalt(II)‐Linked {P8W48} Network Assemblies: Syntheses, Structures, and Magnetic and Photocatalysis Properties
Authors: Jiao Yan‐Qing , Qin Chao , Wang Xin‐Long , Wang Chun‐Gang , Sun Chun‐Yi , Wang Hai‐Ning , Shao Kui‐Zhan , Su Zhong‐Min
Published: November 2013

Three cobalt(II)‐containing tungstophosphate compounds, Na8Li8Co5[Co5.5(H2O)19P8W48.5O184]⋅60 H2O (1), K2Na4Li11Co5[Co7(H2O)28P8W48O184]Cl⋅ 59 H2O (2), and K2Na4LiCo11[Co8(H2O)32P8W48O184](CH3COO)4Cl⋅47 H2O (3), have been synthesized and characterized by IR spectroscopy, thermogravimetric analysis, elemental analyses, and magnetic measurements. The pH value impacts the formation of distinct cobalt‐linked frameworks. The cyclic cavity of the polyanion accommodates 5.5, 7, and 8 cobalt ions in 1, 2, and 3, respectively. In compounds 1 and 2, each {Co5.5P8W48} and {Co7P8W48} fragment links to four others through multiple {Co‐O‐W} coordination bonds to generate a two‐dimensional network. Compound 3 can be considered as a 3D network based on the {Co‐O‐W} coordination bonds and the {Co3(CH3COO)2(H2O)10} linkers between the {P8W48} fragments. Interestingly, acetate ligands have been employed to form the {Co3(CH3COO)2(H2O)10} unit, thereby inducing the construction of a 12‐connected framework. To the best of our knowledge, compound 3 contains the largest‐ever number of cobalt ions in a {P8W48}‐based polyoxometalate when counterions are taken into account and the {P8W48} unit shows the highest number of connections thanks to the carboxyl bridges. The UV/Vis diffuse reflectance spectra of these powder samples indicate that the corresponding well‐defined optical absorption associated with Eg can be assessed at 2.58, 2.48, and 2.73 eV and reveal the presence of an optical band gap. The photocatalytic H2 evolution activities of these {P8W48}‐based compounds are evaluated.
Palladium‐Catalyzed Aminocarbonylation of Aryl Iodides with Amides and N‐alkyl Anilines
Authors: Ran Longfei , Ren Zhi‐Hui , Wang Yao‐Yu , Guan Zheng‐Hui
Published: November 2013

A novel and efficient palladium‐catalyzed aminocarbonylation of aryl iodides with amides and N‐alkyl anilines has been developed. The reaction tolerates a wide range of functional groups and is a reliable method for the rapid synthesis of a variety of valuable imides and tertiary benzanilides under an atmospheric pressure of CO.
Strong Stokes and Upconversion Luminescence from Ultrasmall Ln3+‐Doped BiF3 (Ln=Eu3+, Yb3+/Er3+) Nanoparticles Confined in a Polymer Matrix
Authors: Sarkar Shyam , Dash Armita , Mahalingam Venkataramanan
Published: November 2013

Heavy metal fluorides like BiF3 as a host for lanthanide ions are of interest as bismuth is the only heavy metal that is nontoxic. In this work, we report the synthesis of highly water‐dispersible ultrasmall BiF3 nanoparticles about 6 nm in size within a poly(vinyl pyrrolidone) matrix by a hydrothermal method. Microscopy analysis reveals that the nanoparticles are well separated and confined within the polymer network. These nanoparticles were found to be excellent hosts for lanthanide (Ln3+) ions. Through suitable Ln3+ doping, BiF3 exhibits strong emissions in the visible region upon both UV and near infrared (NIR) excitations. The non‐toxicity of both bismuth and PVP can be advantageous for the potential use of BiF3 nanoparticles in drug delivery and bioimaging.
Motivating Employees towards Sustainable Behaviour
Authors: Temminck Elisha , Mearns Kathryn , Fruhen Laura
Published: November 2013

Workers engaging in voluntary and unrewarded environmental actions that go above and beyond their job requirements in an organizational setting can crucially contribute to a reduced environmental impact of organizations. This research investigates some of the factors that may contribute to the emergence of such organizational citizenship behaviour directed towards the environment (OCBE). The hypotheses predicted employees' concern for the environment, employees' perceived organizational support for environmental efforts and organizational commitment as antecedents of OCBE. Employees from two organizations (n = 547) completed an online survey. Controlling for organizational tenure, a significant relationship between (a) employees' concern for their environment and OCBE, (b) perceived organizational support for environment efforts and OCBE and (c) organizational commitment and OCBE were found. Furthermore, organizational commitment mediated the relationship between perceived organizational support for environmental efforts and OCBE, but not environmental concern. This study's insights into the factors that can drive employees' engagement in small, voluntary environmental actions at work can guide organizations wishing to encourage such behaviours. Copyright © 2013 John Wiley & Sons, Ltd and ERP Environment
An assessment of distance learning laboratory objectives for control engineering education
Authors: Stefanovic Miladin , Tadic Danijela , Nestic Snezana , Djordjevic Aleksandar
Published: November 2013

The concept of web laboratories with remotely controlled laboratory set ups or virtual laboratories with different simulations have an important role in engineering education and training. This paper presents an evaluation of the fundamental objectives of laboratories for distance education, comparing the effectiveness of a remotely controlled approach versus simulations. The results and analysis show that students prefer remotely controlled laboratories compared to simulation labs. The results show that remotely controlled laboratories better fulfill objectives important for laboratory exercises. © 2013 Wiley Periodicals, Inc. Comput Appl Eng Educ 23:191–202, 2015; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21589
Old dogs, new tricks – Rethinking country‐image studies
Authors: Bowe Jasha , Lockshin Larry , Lee Richard , Rungie Cam
Published: November 2013

In international marketing, countries are often conceptualised as image constructs that have an influence on product image formation. Destination image and country of origin image are held to account for bias in consumer perceptions towards products because of the country from which they originate. Studies in these areas are typically underpinned by attitude‐based Likert or semantic differential scale methods, analysed using structural equation models. This paper achieves two key outcomes. Firstly, it adds to the small but growing body of literature that looks at the impact of tourism on post‐tour, export product evaluations. Secondly, it compares this traditional attitude‐based approach to country‐image studies with an alternative associative network theory approach, operationalised with a free‐choice, pick‐any survey method, which is popular within the branding literature. We compare the two methods by applying each to the same set of respondents to establish if the two methods are complementary, and find they produce different outcomes that could have critical implications for how country‐image studies are conceptualised and executed. Copyright © 2013 John Wiley & Sons, Ltd.
The impact of frequent social Internet consumption: Increased procrastination and lower life satisfaction
Authors: Hinsch Christian , Sheldon Kennon M.
Published: November 2013

Organizations are frequently turning to social Internet applications in an effort to form bonds with consumers. However, little research has addressed the impact of social Internet consumption on the individual. Two studies of regular social Internet consumers (i.e., users of Facebook and socially connected online games) examined the effects of prompted usage reduction or cessation upon participants. In both studies, participants benefitted on average during the reduction/cessation period, reporting increased life satisfaction and decreased procrastination. The Facebooker versus gamer factor had remarkably few effects (i.e., results generalized across these two groups). Implications are discussed for both consumers and organizations involved in social Internet activities. Copyright © 2013 John Wiley & Sons, Ltd.
Balancing “We” and “I”: Self‐construal and an alternative approach to seeking uniqueness
Authors: Song Doori , Lee Joonghwa
Published: November 2013

Influenced by the need for uniqueness theory, the current study proposes that expressing uniqueness via consumption offers a means for achieving a different sense of being without damaging the individual's sense of social assimilation. With respect to self‐construal, it is suggested that highly interdependent people satisfy their need for distinctiveness by selecting unique products; meanwhile, individuals with highly independent self‐construal seek out unique products to satisfy their need for uniqueness. Thus, this study demonstrates that, despite the fact that individuals with both types of self‐construal seek out unique products, the reason for seeking uniqueness differs according to the types of self‐construal. Copyright © 2013 John Wiley & Sons, Ltd.
Left atrial appendage occlusion in octogenarians
Authors: Gafoor Sameer , Franke Jennifer , Bertog Stefan , Boehm Patrick , Heuer Luisa , Gonzaga Maik , Bauer Janine , Braut Annkathrin , Lam Simon , Vaskelyte Laura , Hofmann Ilona , Sievert Horst
Published: November 2013

Objectives

To determine the procedural safety, safety, and efficacy of left atrial appendage (LAA) occlusion in octogenarians.

Background

Elderly patients with atrial fibrillation (AF) often do not receive appropriate anticoagulation. LAA occlusion is an option for patients with AF and contraindications to anticoagulation. Not much is known about the procedural safety and clinical efficacy of LAA occlusion in the very elderly.

Methods

A retrospective review of LAA cases at our institution between 2002 and 2013 in patients 80 years of age or older was performed. Demographic, echocardiographic, procedural, and clinical follow‐up data were collected.

Results

Seventy‐five cases were attempted in patients 80 years of age or older (average age 83.4 ± 2.8 years, 53.3% males). Hypertension, coronary artery disease, and heart failure were present in 96, 41.3, and 36%, respectively. Mean CHADS2 and CHA2DS‐VASc scores were 3.3 and 5.2. Devices used included the WATCHMAN, ACP, PLAATO, Lariat, and Coherex devices, which were attempted in 34.7, 36, 17.3, 5.3, and 5.3%, respectively. Overall procedural success, safety endpoint, and 1‐year device efficacy was 90.1, 3.9, and 97.4%, respectively.

Conclusion

LAA closure is a safe and efficacious method of stroke prevention in the very elderly with AF. © 2013 Wiley Periodicals, Inc.
Enhanced Catalytic Activity of Platinum Nanoparticles by Exfoliated Metal Hydroxide Nanosheets
Authors: Lee Jong Hyeon , Kim Hana , Lee Yeon Soo , Jung Duk‐Young
Published: November 2013

A novel 2‐dimensional catalytic system was developed in which platinum nanoparticles (Pt NPs) were immobilized on exfoliated MgAl‐layered double hydroxide (LDH) nanosheets through an electrostatic self‐assembly between negatively charged Pt NPs and positively charged LDH nanosheets. The LDH nanosheets effectively provided the large double sides of hydroxide functionality to absorb the Pt NPs, as well as fast diffusion rates of the incoming reactants into catalyst surfaces. This new nanostructure improved the rate of reaction, turnover frequency and reaction durability of Pt NPs on LDH nanosheet without significant loss in conversion efficiencies for the reduction of p‐nitrophenol into p‐aminophenol by NaBH4, maintaining more than 97% of catalytic conversions compared to free Pt NPs as well as commercial Pt/C catalyst.
Kinetic Study of Catalytic Conversion of Cellulose to Sugar Alcohols under Low‐Pressure Hydrogen
Authors: Komanoya Tasuku , Kobayashi Hirokazu , Hara Kenji , Chun Wang‐Jae , Fukuoka Atsushi
Published: November 2013

Efficient hydrolytic hydrogenation of cellulose to sugar alcohols under low H2 pressures has remained a challenge. This article deals with the conversion of cellulose by using a carbon‐supported Ru catalyst under H2 pressures as low as 0.7–0.9 MPa (absolute pressure at room temperature). Kinetic studies revealed that the Ru catalyst not only enhances the hydrolysis of cellulose to glucose and hydrogenation of glucose to sugar alcohols (sorbitol and mannitol), but also the degradation of sugar alcohols to C2–C6 polyols and gasses. The degradation path limits the total yield of sugar alcohols to less than 40 %. The yield of sugar alcohols is theoretically improved by increasing the ratio of the reaction rates of the cellulose hydrolysis, which is the rate‐determining step in the reaction, to the decomposition. Thus, a mix‐milling pretreatment of cellulose and the Ru catalyst together selectively accelerated the hydrolysis step and raised the yield up to 68 %, whereas the addition of acids in the cellulose conversion was less effective as a result of promotion of side‐reactions. These results demonstrate superior applicability of the mix‐milling treatment in the depolymerization of cellulose to its monomers.
Multi‐Objective Optimization of a Cross‐Flow Plate Heat Exchanger Using Entropy Generation Minimization
Authors: Babaelahi Mojtaba , Sadri Somayyeh , Sayyaadi Hoseyn
Published: November 2013

Multi‐objective optimization of a cross‐flow plate fin heat exchanger (PFHE) by means of an entropy generation minimization technique is described. Entropy generation in the PFHE was separated into thermal and pressure entropy generation as two objective functions to be minimized simultaneously. The Pareto optimal frontier was obtained and a final optimal solution was selected. By implementing a decision‐making method, here the LINMAP method, the best trade‐off was achieved between thermal efficiency and pumping cost. This approach led to a configuration of the PFHE with lower magnitude of entropy generation, reduced pressure drop and pumping power, and lower operating and total cost in comparison to single‐objective optimization approaches.
Fabrication of Efficient NiO Photocathodes Prepared via RDS with Novel Routes of Substrate Processing for p‐Type Dye‐Sensitized Solar Cells
Authors: Awais Muhammad , Gibson Elizabeth , Vos Johannes G. , Dowling Denis P. , Hagfeldt Anders , Dini Danilo
Published: November 2013

p‐type dye sensitized solar cells (p‐DSCs) derived from nickel oxide (NiO) photocathodes have been obtained via rapid discharge sintering (RDS) of parent metal oxide nanoparticles deposited onto differently treated substrates utilizing a plasma atmosphere with microwave radiation as heat source. This method produces NiO thin films (0.6<l<6 μm) with mesoporous features and large surface areas as required for efficient dye‐loading and high photocurrents. Erythrosine B (ERY) was used to sensitize the oxide in the visible spectrum. We have analyzed and compared the photoelectrochemical performances of the p‐DSCs assembled with the various types of NiO samples prepared by RDS techniques with different treatments of the supporting substrate prior to, or during, spray deposition of the NiO nanoparticles. The best photovoltaic performances were obtained when the transparent conducting substrate (TCS) was heated during spraying. We believe that this is because the charge transfer through the NiO film and the charge collection at the TCS/NiO film interface were the most efficient with this sample. To our knowledge, the photovoltaic performances reported here are the best achieved with the commercial dye ERY as sensitizer.