bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of watershed segmentation algorithm and supervised Bayesian classification in the evaluation of petrophysical parameters, pore properties, and lithofacies using 3D seismic data, wireline logs, and SEM images: A case study from Abadan Plain, SW Iran
Authors: Moghanloo Hamed Ghanbarnejad , Riahi Mohammad Ali
Published: September 2023

In this paper, an integrated workflow based on recent geoscience data is presented for assessing the reservoir characterization and structural interpretation of the Burgan formation, a highly productive formation in the Abadan plain, SW Iran. Utilizing newly acquired high-resolution SEM images, we evaluated the pore size, pore distribution, and pore aspect ratio of Burgan formation. The watershed segmentation algorithm is also capable of detecting throats and closed pores. The porosity fractions from SEM images are used for calibration of the porosity log at several well locations in order to perform petrophysical modeling. Since the facies behavior is complex in the study area, we utilized supervised Bayesian classifier using P-wave velocity, density, and facies log dataset. The confusing matrix and machine learning metrics including Accuracy (97.01%), Precision (93.88%), F1 Score (94.16%), and False Positive Rate (2.52%), indicate that the classifier has been properly trained at well locations. A reasonable match is evident between the modeled petrophysical parameters and the true (core) porosity and water saturation at the location of the test well. Furthermore, we have demonstrated the validity of assumptions concerning the dominance of extensional structure in the Abadan plain by using interpreted seismic data. The presented workflow can be used to optimize drilling operations and reduce risks in similar geological settings in the studied formation.
Do Trade-adjusted Emissions Perform better in Capturing Environmental Mishandling among the most Complex Economies of the World
Authors: Hossain Mohammad Razib , Dash Devi Prasad , Das Narasingha , Hossain Md. Emran , Haseeb Mohammad , Cifuentes-Faura Javier
Published: September 2023

With the emergence of new environmental challenges, the direction of environmental research is changing exponentially. To implement anti-warming and pro-environmental interventions, it is vital that we adopt robust and reliable measures of environmental degradation. Any exception to this will breed inaccurate forecasts, generating loopholes in the policies. In this milieu, we juxtapose how trade-adjusted emissions (CCO2) and total emissions (CO2) respond as we set shock on environmental technology (EVT), Economic Complexity Index (ECI), natural resource rent (NRT), research and development (R&D), and energy efficiency (EFX) from 2000–2020 across the OECD nations. We also control GDP and renewable energy consumption (RWE). The findings of the novel non-parametric method of moments quantile regression (MMQR) reveal that EVT has an insignificant positive impression on CCO2, whereas it has a heterogenous impact on CO2 emissions. Moreover, ECI cuts trade-adjusted emissions, indicating that complex economies like OECD’s have better emissions reduction potentiality through export diversification. However, we unveil a paradoxical relationship in the ECI-CO2 nexus since total emissions do not account for trade-adjusted emissions. R&D surges CO2 and CCO2 emissions, demonstrating that efforts to achieve sustainability have been a failure on a regional scale, where the latter is statistically insignificant. Furthermore, EFX increases total emissions, indicating a rebound effect among the OECD territories. We also note different causal relationships to rectify the results’ robustness. Our findings thus enrich the streaming literature by juxtaposing how different measures of environmental degradation respond over a series of empirical shocks and establishing that trade-adjusted emissions are better indicators of environmental degradation, exclusively in the context of complex economies.
Utility of routine histological examination of ileostomy reversals
Authors: Quinn Rakesh , Sidhu Ankur , Saad Jeremy , Shakeshaft Anthony , Albayati Sinan
Published: September 2023

Purpose Diverting ileostomies are frequently used when bowel anastomosis is not feasible or to divert faeces from high-risk anastomoses. Despite being unrelated and distant to the initial pathology, histopathological examination is commonly requested. The aim of this study is to identify the benefit of histopathological analysis of these specimens and their impact on patient management.Methods A retrospective review was conducted on all patients who underwent a reversal of ileostomy at a tertiary referral teaching hospital between January 2016 to July 2021. Patient demographics, stoma indication, histopathological reports and post-operative outcomes were reviewed.Results The study identified 87 cases of ileostomy reversals between January 2016 and July 2021. The mean age of the patients was 58 years old; 62 (71.2%) patients were male. Seventy-three (83.9%) stomas were formed electively, the majority of these for ultralow or low anterior resections (39 and 17 patients respectively). A further 13 (14.9%) stomas were formed in the emergency setting, 1/13 (7.7%) cases were due to a malignant pathology and 12/13 (92.3%) were benign conditions. Overall, forty-three samples were reviewed, 42 (97.7%) of these showed normal small bowel histopathology and malignancy was identified in only 1 (2.3%) specimen. Due to frailty, there was no further active management for the patient with the malignant pathology.Conclusion Selective histopathological examination may be of value in macroscopically suspicious or high-risk patients for peritoneal disease based on primary pathology, however the utility in routine use requires further evaluation.
Recurrence of Supraventricular Tachycardia in Children: Who is at Risk, and What is the Outcome?
Authors: Bah Mohd Nizam Mat , Zahari Norazah , Boparam Baljit Kaur , Sapian Mohd Hanafi
Published: September 2023

Introduction: Limited data are available concerning supraventricular tachycardiac (SVT) recurrence. Hence, this study aimed to determine the incidence, outcome, and factors associated with SVT recurrence. Methods: This retrospective, observational, population-based study was conducted among children with SVT from 2006 to 2020. The primary outcome measure was SVT recurrence. Kaplan Meier analysis was used to estimate SVT-free at 1, 5, and 10 years after diagnosis. Cox regression analysis was used to identify independent factors associated with recurrence. Results: There were 156 patients with SVT with a median age at diagnosis of 1.9 years (Interquartile range [IQR] 11 days to 8.7 years) and follow-up for a median of 3.5 years (IQR 1.7 to 6.1 years). Thirty-five patients (22%) had recurrent SVT at a median age of 7.8 years (IQR 4.4 to 12 years). Infants with Wolf-Parkinson-White Syndrome (WPW) had the highest recurrence (11/16, 68%), with 33% SVT-free at 5 years follow-up. The lowest recurrence rate was observed in neonatal diagnosis (2/54,3.7%) with 98% SVT-free at 5 years follow-up. The independent factors associated with the recurrence of SVT were the diagnosis of WPW with an adjusted hazard ratio (aHR) of 5.6 (95%CI 2.6–12.2), age of more than one year at diagnosis (aHR 4.3 95%CI 1.7–10.8), and combine and second-line therapy (aHR 4.1 95%CI 1.6–10.7). Conclusion: One in five children with SVT experienced a recurrence, which is more likely for those with WPWs, multiple maintenance therapy, and older age at first presentation. Whereas neonates with non-WPW may benefit from shorter maintenance therapy.
Why induced earthquakes occur on conventionally stable faults: frictional healing explains
Authors: Li Meng , Niemeijer Andre , Dinther Ylona Van
Published: September 2023

Conventional studies suggest that faults in the shallow subsurface should be resistant to earthquake nucleation, because their frictional strength increases as slip accelerates. Yet, such faults frequently exhibit earthquakes induced by human intervention. Here we explain this paradox by showing, through numerical simulation using rate-and-state friction, that single earthquakes can nucleate on velocity-strengthening faults, following fault “healing” over thousands to millions of years. However, subsequent slip on human lifetimes is stable and aseismic. We apply our approach to assess the potential of any fault to host induced seismicity, in terms of the healing time needed to produce fast slip and sufficient stress drop upon fault reactivation. This demonstration of how earthquakes occur on conventionally stable, velocity-strengthening faults is critical for correctly assessing which sites can be safely targeted in exploiting the subsurface for applications such as geothermal energy production and energy storage.
CACNA1E, C4BPA is causally associated with gastric cancer: A Mendelian randomization study
Authors: Zhang Fei , Zhao Qi , Liu Jiemin , Chu Mingliang , Huang Jing , Tang Yun
Published: September 2023

Background: Gastric cancer (GC) is influenced by several risk factors such as smoking and high intake of cured foods. However, the effect of some molecules on incidence of GC have not been demonstrated. In this study, Single-Variable Mendelian Randomization (SVMR) and Multi-Variable Mendelian Randomization (MVMR) were utilized for estimating the causal association between calcium voltage-gated channel subunit alpha 1E (CACNA1E), C4b binding protein alpha (C4BPA) and GC.
Methods: The Genome-Wide Association Study (GWAS) ids for GC and exposure factors were derived from Integrative Epidemiology Unit (IEU) Open GWAS database. Including 6563 GC samples and 195,745 control samples, and there were 8,885,324 Single Nucleotide Polymorphisms (SNPs) for GC. The sample size for CACNA1E was 31,684, and the number of SNPs was 18,413. The sample size for C4BPA was 14,263, and the number of SNPs was 15,879. The SVMR studies were conducted to estimate the risk of CACNA1E and C4BPA in GC using MR Egger, weighted median, inverse variance weighted (IVW), simple mode and weighted mode. Importantly, IVW was the most major method. In addition, sensitivity analysis was conducted to assess the reliability of MR results, which mainly consisted of the heterogeneity, horizontal pleiotropy and Leave-One-Out (LOO). Finally, the MVMR analysis was carried out.
Results: The SVMR indicated that CACNA1E and C4BPA are causally related to GC, with C4BPA (P=0.006, OR=1.032) as a risk factor and CACNA1E (P=0.005, OR=0.827) as a protective factor. The reliability of SVMR results was demonstrated by sensitivity analysis. The MVMR analysis was consistent with the outcome of SVMR, implicating C4BPA as a cause of GC, whereas CACNA1E is a protective factor against GC.
Conclusion: A causal relationship between CACNA1E, C4BPA and GC was confirmed by our study, and increased C4BPA expression elevates the prevalence of GC and vice versa for CACNA1E.
Long-term effects of splenectomy on innate and adaptative immunity
Authors: Ouandji Sethi , Ciudad Marion , Cladière Claudie , Greigert Hélène , Samson Maxime , Audia Sylvain , Martin Laurent , Bonnotte Bernard
Published: September 2023

Purpose
The aim of our study was to investigate the long-term effects of splenectomy on the immune response and to compare these effects in two groups of patients splenectomized for different reasons, autoimmune cytopenia or following trauma, and healthy non-splenectomized controls in a single-center cohort study.
Methods
Among 248 patients splenectomized for ITP or trauma between 1995 and 2015 at Dijon University Hospital, 15 patients randomly selected from the two groups and 10 matched controls (healthy non-splenectomized patients) were analyzed.
Results
Splenectomized patients in both ITP and trauma groups had a higher circulating cell count and percentage of B lymphocytes than controls, a significant decrease in memory B cells, memory IgM B cells, marginal zone B cells and switched memory B cells. On the other hand, we found no changes in the different T-cell subsets of patients splenectomized for ITP or trauma and controls, with the exception of an increase in circulating CD8+ central memory T cells in both splenectomized groups compared to controls. Interestingly, we also found a decrease in the phagocytosis capacity in the splenectomized ITP group, partially corrected by the addition of tuftsin, but no abnormalities in the oxidative functions.
Conclusion
In summary, we demonstrated long-term immunological consequences of splenectomy which did not differ according to the indication for splenectomy, ITP or trauma and noted a decline in phagocytic capacity.
Investigating the Intersegmental Veins between S6 and S7 in Anatomical Resection
Authors: Li Hang , Cheng Zongbing , Dai Yukai , Song Xiaodong , Han Mengling , Mo Zengyi
Published: September 2023

Background
Hepatocellular carcinoma often metastasizes along the portal vein watershed, necessitating precise anatomical resection. Anatomic resection (AR) involving segments S6 and S7 aims to enhance oncological efficacy while preserving liver volume. The intersegmental veins (IVs) between these segments are potential anatomical landmarks that facilitate accurate resection plane determination.
Methods
Three-dimensional (3D) reconstruction technology was used to analyze the IVs between S6 and S7 in 164 patients who underwent contrast-enhanced computed tomography (CT). The IVs' occurrence rate, characteristics, spatial localization, and correlation with right hepatic veins (RHVs) diameters were examined.
Results
IVs were identified in 71.95% of patients, primarily connecting to RHVs. They often converged in the middle-lower portion of RHVs. The most clearly identifiable junctions between the IVs and RHVs occurred the midpoint of the horizontal planes of the second hepatic portal and the center of the gallbladder bed. Patients with larger RHV diameters were more likely to have IVs draining into RHVs (Type 1), while smaller RHV diameters correlated with IVs draining into inferior right hepatic veins (IRHVs) (Type 2).
Conclusion
The IVs between S6 and S7 are prevalent and feasible anatomical landmarks for AR. When RHVs and IRHVs coexist, the RHV diameter predicts the type of IVs present. Considering the IVs enhances precision in determining transection planes during AR of S6 and S7, potentially reducing blood loss and enhancing patient safety. Further research is needed to validate these findings and address limitations in sample size and hemodynamic variations.
RETRACTED: Novel loss of function mutation in MERTK gene, the first report of an Iranian family with an autosomal recessive inheritance of retinitis pigmentosa
Authors: Vazifehmand Reza , Homaie Foroozandeh Monem , Massiha Alireza , Ali Dhuha Saeed , Najafi Mohsen
Published: September 2023

The authors have requested that this preprint be removed from Research Square.
A Statistical Model of Gross Errors and Model Parameters Estimation
Authors: Yu Yangkang , Yang Ling , Shen Yunzhong
Published: September 2023

This contribution introduces a statistical model of gross errors, which is called the Bernoulli-Gaussian (BG) model, where the gross error consists of the product of a Bernoulli variable and a Gaussian variable. First, with the BG model, different causes of outliers can be interpreted from the perspective of gross errors. As well, the commonly used observation models, such as the mean shift model and variance inflation model, can be unified by the BG model, via choosing different values range of model parameters. Second, based on the EM (expectation maximization) algorithm, the estimation method of BG model parameters for linear observation equations is proposed. With this method, the BG model parameters can be estimated in both a static observation system and a dynamic observation system. Finally, normal sample examples and GNSS examples proved that it is effective in estimating the BG model parameters via the the EM algorithm.
Genome-Wide Identification of Ascorbate Peroxidase Gene Family in Two Contrasting Barley (Hordeum vulgare L.) Cultivars: Essential Roles in Various Abiotic Stress Tolerance
Authors: Saidi Abbas , Hajibarat Zohreh , Ghazvini Habibollah
Published: September 2023

Plants with their antioxidant defense systems evolved under stress conditions and detoxify and remove the levels of reactive oxygen species (ROS). The survey of ascorbate peroxidase (APX) gene families in barley identified eight APX genes. The comprehensive analysis of HvAPX genes in barley has not yet been described. In this study, 8 members of the barley APX family were characterized for phylogenetic tree, conserved motifs, gene ontology, correlation between traits and gene expression, prediction of cis-elements, and gene expression in APX under abiotic stress conditions. In addition, analysis of physiological traits was performed on two contrasting Iranian barley cultivars namely Sahra (drought tolerant) and Nobahar (drought susceptible) under abiotic stress (PEG, heat, ABA, and salt) conditions. Gene expression analysis revealed that 8 HvAPX genes were accumulated in the leaf and root tissues at 24 and 48 hours after abiotic stresses. Furthermore, the gene expression analysis of the HvAPX genes revealed genes increase and decrease in response to PEG, ABA, salt, and heat stresses in the leaf and root tissues. The phylogenetic analysis of the HvAPX proteins sequences in barley were grouped into three clusters. The HvAPX7 and HvAPX8 genes had the highest number of cis-elements in their promoter regions, indicating that they might be stimulated by a plethora of environmental stresses. The HvAPX genes had GT1-motif, STRE, CAAT-box, MYB, and MYC in their promoter regions, playing a key role in response to abiotic stresses. Our findings provide new insights into APX genes and provide a basis for next investigations of APX genes in plant improvement (breeding) programs.
A comparative study of retrograde intrarenal surgery versus percutaneous nephrolithotomy for the management of staghorn renal calculi
Authors: Xu Xiang , Liao Sucai , Wei Genggeng , Jiang Yi , Lu Zhengquan , Yu Peter S.Y. , Xiong Lin
Published: September 2023

Background Due to the advancements in equipment and techniques, the indications for Retrograde IntraRenal Surgery (RIRS) have been expanded. However, there is limited research on the application of RIRS in the treatment of staghorn renal calculi. We aimed to compare the effectiveness and safety of RIRS and Percutaneous Nephrolithotomy (PCNL) as treatment modalities for staghorn renal calculi.Method We conducted a retrospective analysis of clinical data for all patients with staghorn renal calculi underwent treatment with either RIRS or PCNL at our hospital, and compared the perioperative outcomes and complications of the two groups.Results From April 2021 to March 2023, 47 patients underwent RIRS, while 45 patients underwent PCNL for the treatment of staghorn renal calculi. 1. There were no significant difference between the two groups in terms of number of complete staghorn calculi, stone size, mean number of surgery, total operative time. 2. RIRS was associated with shorter total hospitalization time(8.1 ± 8.4 VS 16 ± 8.7 days, p < 0.001) and postoperative hospitalization time(2.1 ± 0.8 VS 5.1 ± 2 days, p < 0.001). 3. RIRS showed less decrease in hemoglobin (1.92 ± 1.63 VS 8.99 ± 6.41 g/l, p < 0.001) and pain score (1.7 ± 0.7 VS 2.5 ± 1.1, p < 0.001). 4. RIRS demonstrated no significant difference in terms of 1 stage stone-free rate (51.1% VS 40%, p = 0.29) and total stone-free rate (78.3% VS 88.9%, p = 0.12), compared with PCNL. 5. The overall complication rate was lower in the RIRS group, with no significant difference (8.5% VS 15.6%, p = 0.30).Conclusion RIRS can reduce bleeding and overall complication, shorten hospitalization time, achieve satisfactory stone-free rates, when compared to PCNL. As a result, RIRS can be considered as an alternative treatment option for staghorn renal calculi.
Association of serum uric acid with hypertriglyceridemia in children and adolescents: a cross-sectional study
Authors: Si Shang-an , Chen Meng-Qi , Zhang Guiju
Published: September 2023

Background: Uric acid (UA), a liver-derived metabolite, is intimately tied to metabolic disorders. Although ample research underscores its connection with hypertriglyceridemia (HTG), studies focusing on adolescents remain limited. This investigation delves into the correlation between uric acid levels and HTG among American adolescents.
Methods: This cross-sectional study utilized data on 4,435 adolescents from the NHANES database spanning 2011 to 2020. The exposure variable was serum uric acid (SUA), the outcome variable was HTG, and the covariates encompassed demographics, questionnaire, physical examination and laboratory indicators. We utilized weighted logistic regression and meticulous subgroup evaluations to discern the intrinsic link between SUA and HTG. Stratified analyses augmented the validation of this association, while smooth curve fitting probed for potential non-linear correlations.
Results: The study included 4,435 participants. Male adolescents might exhibit elevated SUA levels. After adjusting for all variables, the weighted multiple logistic regression model revealed that SUA had a positive correlation with HTG risk. This relationship was consistent across tertiles. Stratified analyses confirmed that the positive correlation between SUA and HTG risk was significant, irrespective of sex, age and race.
Conclusions: In American children and adolescents aged 12 to 18 years, there's a pronounced affiliation between SUA and HTG. SUA could serve as a risk indicator for HTG. Regular monitoring of serum triglycerides is recommended to prevent HTG during childhood.
Circular RNA PVT1 Promotes Breast Cancer Progression via miR-30b-5p/AEG-1 Axis
Authors: Li Ying-dong , Li Wenfang , Ai Yong-biao , Zhang Tian-xiang
Published: September 2023

Background: Circular RNA PVT1 (circPVT1) has been reported to be a vital modulator in tumorigenesis. However, the detailed regulatory mechanism of circPVT1 in breast cancer (BC) remains largely unclear.
Objective: This research is to explore the mechanisms of circPVT1 in breast cancer from different perspectives.
Methods: In this work, the expressions of circPVT1 and microRNA-30b-5p (miR-30b-5p) were detected by quantitative real-time PCR (qRT-PCR) in breast cancer tissues and cell lines. The Kaplan-Meierk was adopted to compare disease free survival (DFS) and overall (OS). BC cell lines MDA-MB-231and MCF-7 cell lines were chosen for the following assays. After circPVT1 was depleted, CCK-8 and Transwell assays were performed to examine the cell viability and invasive capacity. Astrocyte elevated gene 1 (AEG-1) protein level was measured by western blot. The competitive endogenous RNA molecular mechanism among circPVT1, miR-30b-5p and AEG-1 was verified by bioinformatics analysis, luciferase-reporter gene assay.
Results: In the present study, it was revealed that circPVT1 expression was remarkably evaluated in BC tissues and cell lines than that in the corresponding control group. The Kaplan-Meier analysis shown that high circPVT1 expression had a significantly poorer survival prognosis than those with low circPVT1 expression in DFS (χ2 = 7.174, P = 0.007) and OS (χ2 = 3.946, P = 0.047). CircPVT1 positively regulated the proliferation, migration and invasion progression of BC cells. Besides, miR-30b-5p was identified as a target of circPVT1, and AEG-1 was identified as a target of miR-30b-5p. The depletion of circPVT1 promoted the expression of miR-30b-5p and suppressed AEG-1 expression. Moreover, simultaneous inhibition of miR-30b-5p expression in the circPVT1 knockout group could reverse the inhibition of AEG-1 expression.
Conclusion: In conclusion, our results indicate circPVT1 regulates AEG-1 expression by competitively binding to endogenous miR-30b-5p in breast cancer cells. CircPVT1 promoted AEG-1 expression by negatively regulating miR-30b-5p expression to enhance the cell viability, migration, and invasion progression of BC cells. Our results reveal a new molecular therapy target for breast cancer.
Electrochemical synthesis of Cu-Fe/brass foil alloy and its oxides under the combustion process as a promising photoelectrode for efficient hydrogen evolution in alkaline solutions
Authors: Kholidy Islam , Sabt Mohammad H. Bin , El-Salam H. M.Abd , Shaban Mohamed , Rabia Mohamed
Published: September 2023

Copper, iron, and their alloys are electrochemically prepared on brass foil (77%Cu-33% Zn) plate, from different concentrations of aqueous solution (0.05 to 0.25 M ) of CuCl2 and (0.02 to 0.25 M ) FeCl3, respectively, in which three different concentrations solutions are prepared. XRD, XPS, SEM, and cyclic voltammetry techniques were applied to explore the structures, morphologies, and electrochemical (EC) activities of the deposits. Alloy Oxide with the chemical composition of (30Cu-2.5Fe-35Zn-32.5O) has different phases (CuFeO2 and CuFe2O4) are the major and (Cu-Fe, CuO, ZnO, and Fe2O3) are a minor materials prepared under the combustion reaction. Before combustion, there are two different alloy, the first one is Alloy(I) deposited from solution (0.25M CuCl2 + 0.02M FeCl3) with the chemical composition of (80Cu-2Fe-16Zn-2O) and the second one is Alloy(II) deposited from solution (0.05M CuCl2 + 0.25M FeCl3) with the chemical composition of (60Cu-0.25Fe-36.75Cu-3O) both of them have different phases of Cu, CuO, Fe(OH)2, Fe2O3, Cu-Zn, CuFeO2, and Cu-Fe are confirmed by XRD. The intensity of the peaks depends on Cu%. Furthermore, the high purity of the Cu–Fe alloys was confirmed by EDX techniques. The surface of alloys which are prepared from high concentration of FeCl3 is rough and agglomerated compared to the alloys prepared from high concentrations CuCl2. The H2 evolution reactions (HER) in alkaline solution using these alloys were investigated through electrochemical polarization (ECP) measurements and EC impedance spectroscopies (EISs). alloy(I) with 708 mA Cm− 2 at potential 2.04 V has a high rate of hydrogen production. Also alloy oxide is a burned alloy, tested as a photoelectrode material under a solar simulator with 400 mW cm− 2.It given current density under dark and light are 2.54 mA/Cm2 and 33 mA/cm2, respectively.
Structural connectivity alterations in mild cognitive impairment patients with depression symptoms: a DTI-based connectome analysis
Authors: Yang Ting , Hou Hongtao , Wei Fuquan , Guo Zhongwei , Zhang Jiangtao , Ding Yanping , Liu Xiaozheng
Published: September 2023

Studies have shown that depressive symptoms cause changes in brain structural network, but the characteristics of brain structural network in mild cognitive impairment with depression symptoms (D-MCI) are not well understood. In this study, we used diffusion tensor imaging and graph theory analysis to investigate abnormalities in brain structural networks in mild cognitive impairment with depression symptoms. We acquired magnetic resonance imaging data from 50 subjects on a 3T MRI. Subjects collected included 14 patients with D-MCI, 18 patients with MCI with no depression (nD-MCI), and 18 healthy controls. We utilized the network-based statistics method to explore the changes in the structural networks between the three groups and the classification capabilities combined with machine learning methods. In contrast to healthy controls, the anomalous subnetworks of MCI revealed by network-based statistics are mainly located in the default mode network, basal ganglia and sensorimotor regions. The classification accuracy of machine learning models is D-MCI vs nD-MCI: 77.5%; D-MCI vs healthy controls: 90.0%; nD-MCI vs healthy controls: 86.7%. Our results suggest that depressive symptoms cause changes in structural network in patients with MCI, and that these changes can be used to distinguish between D-MCI, nD-MCI, and healthy controls.
ASPAD Dynamic Simulation & Artificial Neural Network for Acetaminophen Adsorption in Biochar Packed Bed Column
Authors: Sabri Muhamad Haikal Daniel Mohamad , Ahmad Anis Atikah , Ahmad Mohd Azmier
Published: September 2023

The presence of acetaminophen (ACT) as a significant pollutant in domestic and hospital wastewaters has raised concerns regarding its removal from these sources. In this study, researchers focused on comparing the breakthrough and saturation time of ozone-treated granular activated carbon (GAC) for the removal of ACT. The dynamic simulation of an adsorption column using Aspen Adsorption (ASPAD) was employed, and the effects of flow rate, ACT initial concentration, and bed height on breakthrough curves were investigated. The results indicated that increasing the bed height led to longer breakthrough and saturation times, accompanied by higher adsorption capacity. Conversely, higher initial concentrations of ACT resulted in reduced breakthrough and saturation times. Similarly, higher flow rates led to shorter breakthrough and saturation times. The optimal operating conditions for achieving the highest breakthrough and saturation were identified as a bed height of 45 cm, ACT initial concentration of 40 mg/L, and flow rate of 2 mL/min. The simulation results were validated against experimental findings, demonstrating satisfactory agreement between the two. Furthermore, an Artificial Neural Network (ANN) model was developed to predict the outlet concentration ratio, exhibiting reliable performance with a low mean squared error value. By understanding the impact of various factors on breakthrough and saturation times, researchers can optimize the design and operation of adsorption columns for efficient ACT removal. The reliable ANN model developed in this study can also aid in predicting outlet concentration ratios, providing a valuable tool for future research and application in wastewater treatment processes.
TrkB-mediated sustained neuroprotection is sex-specific and ERα dependent in adult mice following neonatal hypoxia ischemia
Authors: Chanana Vishal , Hackett Margaret , Deveci Nazli , Aycan Nur , Ozaydin Burak , Cagatay Nur Sena , Hanalioglu Damla , Kintner Douglas B. , Corcoran Karson , Yapici Sefer , Camci Furkan , Eickhoff Jens , Frick Karyn M. , Ferrazano Peter , Levine Jon E. , Cengiz Pelin
Published: September 2023

Background Neonatal hypoxia ischemia (HI) related brain injury is one of the major causes of life-long neurological morbidities that result in learning and memory impairments. Evidence suggests that male neonates are more susceptible to the detrimental effects of HI, yet the mechanisms mediating these sex-specific responses to neural injury in neonates remain poorly understood. We previously tested the effects of treatment with a small molecule agonist of the tyrosine kinase B receptor (TrkB), 7,8-dihydroxyflavone (DHF) following neonatal HI and determined that females, but not males exhibit increased phosphorylation of TrkB and reduced apoptosis in their hippocampi. Moreover, these female-specific effects of the TrkB agonist were found to be dependent upon the expression of ERα. These findings demonstrated that TrkB activation in the presence of ERα comprises one pathway by which neuroprotection may be conferred in a female-specific manner. The goal of this study was to determine the role of ERα−dependent TrkB-mediated neuroprotection in memory and anxiety in young adult mice exposed to HI during the neonatal period.
Methods In this study we used a unilateral hypoxic ischemic (HI) mouse model. ERα+/+ or ERα-/- mice were subjected to HI on postnatal day (P) 9 and mice were treated with either vehicle control or the TrkB agonist, DHF, for seven days following HI. When mice reached young adulthood, we used the novel object recognition, novel object location and open field tests to assess long-term memory and anxiety like behavior. The brains were then assessed for tissue damage using immunohistochemistry.
Results Neonatal DHF treatment prevented HI-induced decrements in recognition and location memory in adulthood in females, but not in males. This protective effect was absent in female mice lacking ERα. Thus, the female-specific and ERα-dependent neuroprotection conferred by DHF therapy after neonatal HI was associated with improved learning and memory outcomes in adulthood. Interestingly, DHF triggered anxiety like behavior in both sexes only in the mice that lacked ERα. When we assessed the severity of injury, we found that DHF therapy did not decrease the percent tissue loss in proportion to functional recovery. We additionally observed that the presence of ERα significantly reduced overall HI-associated mortality in both sexes.
Conclusions: These observations provide evidence for a therapeutic role for DHF in which sustained recovery of memory in females is TrkB-mediated and ERα-dependent. However, the beneficial effects of DHF therapy did not include reduction of gross tissue loss but may be derived from the enhanced functioning of residual tissues in a cell-specific manner.
some new results in generalized weighted core inverse in Banach *-algebras
Authors: Chen Huanyin , Abdolyousefi Marjan Sheibani
Published: September 2023

We present new properties of generalized weighted core inverse in a Banach *-algebra. We characterize generalized weighted core inverse by using the polar-like property. The reverse order law for generalized weighted core inverse is established. The properties of generalized weighted core orders are thereby investigated.
2020 Mathematics Subject Classification. 15A09, 16U99, 46H05
Цифровая идентичность: взаимосвязь смысложизненных ориентаций и содержания личного профиля пользователя социальной сети
Authors: Созинова Мария В. , Чан-Сян Милена А.
Published: September 2023

В данной статье представлено исследование, в котором рассматривается взаимосвязь смысложизненных ориентаций и содержания личного профиля пользователя социальной сети. Авторы предлагают новый взгляд на личные аккаунты в социальных сетях, подчеркивая их эквивалентность дневниковым записям прошлых веков. Обращается внимание на то, как информация, представленная на страницах пользователей, отражает их психологическое состояние, направленность личности и мировоззрение. Новизна исследования заключается в изучении того, как убеждения человека о смысле жизни отражаются в контенте, которым он делится в киберпространстве. Изучая эту взаимосвязь, мы получаем представление о том, как люди выражают свои ценности, цели и перспективы через свое присутствие в сети. Данное исследование предлагает более глубокое понимание того, как люди передают и сообщают свой личный смысл и жизненные ориентации в цифровой сфере. В качестве методов исследования использовались опрос (а именно, тест смысложизненных ориентаций (СЖО) Д. А. Леонтьева), контент-анализ, математические методов обработки данных. Для исследования случайным образом была сформирована выборка из 54 пользователей с открытыми публичными профилями социальной сети возрастом от 16 до 22 лет, в равном количественном соотношении мужчин и женщин. В каждом аккаунте было отобрано от 20 до 24 фотографий. Была разработана инновационная процедура контент-анализа фотографий, представленных в социальных сетях. Для классификации изображений по контексту было сформулировано 9 категорий: учеба/работа, активный отдых, пассивный отдых, творчество, достижения, люди, внешность, пейзаж, другое. Было разработано руководство по кодированию изображений, обеспечивающее межкодерную валидность, в соответствии с ним были проанализированы фотографии и разделены на категории. После проведенного корреляционного анализа были выявлены взаимосвязи между оценками по шкалам теста СЖО и категориями контент-анализа. Анализ данных корреляций предлагается в статье.
A Systematic Review and Meta-analysis of Convergence Insufficiency Prevalence and Management Options
Authors: Mohamed Zoelfigar , Alrasheed Saif Hassan
Published: September 2023

Background:

Convergence insufficiency (CI) is one of the most common binocular vision disorders. The condition negatively affects the quality of life through its impact on near activities, while there is a large gap in the information on its global prevalence and consensus on treatment.

Objectives:

The purpose of this systematic review and meta-analysis was to assess the prevalence and treatment options available for convergence insufficiency.

Methods:

The study was performed in 2023 using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA-2020) guidelines. The authors have searched Google Scholar, Research Gate, Scopus, PubMed, Index Medicus, Web of Science, and the JAMA network. This review included peer-reviewed studies published between January 2000 to January 2023 that assessed the prevalence and treatment modalities of convergence insufficiency.

Results:

The authors screened 13250 studies, 20 for prevalence and 15 for treatment from 12 countries that met the inclusion criteria for the study. The overall pooled prevalence of convergence insufficiency was 7.98%, and the heterogeneity between the studies was highly significant P < 0.0001. Majorities of the studies 12(80%) reported that office-based vision therapy is the most effective treatment of CI, form those studies 5(42.0%) highlighted that office-based vergence/accommodative therapy with home reinforcement is the best modality of treatment. Whereas, home-based pencil push-up therapy, vision therapy with modified refractive correction, and vision therapy with prismatic correction were reported as effective treatment options for CI. The reviewed studies showed that vision therapy is highly effective to recover from symptomatic CI in both adults and children.

Conclusion:

The prevalence of convergence insufficiency was high, there was highly significant heterogeneity between the reviewed studies. Office-based vergence/accommodative therapy with home reinforcement is the best modality of treatment, followed by home-based pencil push-up therapy, vision therapy with modified refractive correction, and vision therapy with prismatic correction. There is consensus among reviewed studies that vision therapy is highly effective to recover from symptomatic CI in both adults and children.
Evaluation of Quality of Paper Reporting Online and Face-to-Face Family Medicine Congresses: A Cross-Sectional Study
Authors: GÜRSOY Ersan , YAĞIZ Mercan
Published: September 2023

Objective: Our study aimed to evaluate the paper reporting quality of the 18th National Family Medicine Congress, which was held face-to-face before the COVID-19 pandemic, and the 19th National Family Medicine Congress, which was the first online congress during the pandemic, according to the STROBE criteria.
Methods: Our study is cross-sectional analytical. Oral and poster abstracts accepted and included in the congress abstract book were included in the study. A total of 266 abstracts were reviewed. STROBE score was created out of 11 points in total by giving a "1" point if the abstract included the feature in each item and a "0" if it did not. The STROBE scores were compared by evaluating the abstracts separately by two different reviewers. Descriptive statistics, Chi-square test, Student's t-test, Pearson correlation, and Mann-Whitney U test were used. The statistical significance level was taken as p<0.05.
Results: Although the rate of verbal presentations was higher in the online congress, there was no significant difference between the congresses regarding the types of papers. In 93.2% of the papers, sampling was not done, or it was not stated that it was done. All of the 18 papers stated to be sample calculations were verbal. When all papers were included, the mean STROBE scores of verbal papers were statistically significantly higher than the scores of poster papers in both reviewers. When the presentation scores according to the congresses were examined, no significant difference was found between the 18th and 19th National Family Medicine Congresses in the same groups.
Conclusion: The online congress format did not affect the reporting quality of the papers. Both congresses have good reporting quality but have the potential for improvement.
Dominant factors that determine college students completing studies in mathematics education study programs
Authors: Dewanti Sintha Sih , Pramono Aji Joko Budi
Published: September 2023

Failure to graduate on time is a problem for both the university and the students themselves. Beside the competencies possessed by students, many other factors affect the completion of student studies. This study aims to reduce the variables that really affect the completion of student studies. The approach of this research was survey research on students of the Mathematics Education Study Program at least in semester 7 (currently taking a final project course). There are 17 factors that determine the completion of student studies, namely achievement motivation, discipline, interest, intelligence, study habits, health, part-time work activities, organizational activities, curriculum, mentoring methods, student relations with lecturers, availability of books, internet facilities, family economic conditions, relationships with parents and family members, friends, and social environment. Data analysis was conducted using Principal Component Analysis (PCA) method to obtain the dominant factor. Based on the results of the study, four main factors that affect the completion of student studies are formed, namely: (1) the first factor: motivation and academic ability; (2) the second factor: activities and social environment; (3) the third factor: facilities and family; and (4) the fourth factor: thesis guidance. The four factors can explain the dominant factor in student study completion at 86.54%, with details of motivation and academic ability at 37.57%, activities and social environment at 26.34%, facilities and family at 15.21%, and thesis guidance at 7.42%.
Introducing a Novel Intervention, CoHealing, to Address Teacher Burnout and Indirect Trauma
Authors: King Jennifer , Holmes Megan , Evans Kylie , Bender Anna , King-White Dakota
Published: September 2023

The COVID-19 pandemic exacerbated the long-standing issues of stress and burnout in the education sector, with teachers and education staff facing unprecedented challenges including significant adjustments to teaching methods and balancing the mental health and academic needs of their students. The resulting challenges have contributed to heightened levels of stress and burnout among teachers and education staff. The impact of the pandemic on teachers and education staff has highlighted the need for greater support and resources to help them cope with these challenges and address their stress and burnout. One such promising intervention, CoHealing, is aimed at promoting a more resilient, interdisciplinary network of trauma-informed helping professionals (e.g., teachers, medical providers, social workers) by reducing secondary traumatic stress, burnout, and isolation. CoHealing is a monthly group-intervention delivered over six months that aims to reduce secondary traumatic stress, burnout, and isolation. CoHealing provides self-regulation tools, relational connection as a coping resource, and psychoeducation on the causes and symptoms of indirect trauma. CoHealing was born out of the need to enhance the relational health of trauma-informed helping professionals and to address indirect trauma and job-related vicarious trauma, secondary traumatic stress, and compassion fatigue across disciplines. Reducing the damaging effects of indirect trauma is critical to maintaining a healthy and resilient workforce that will, in turn, continue to provide high-quality health and human services to individuals and communities experiencing trauma and adversity. This paper provides an intervention description with limited preliminary evidence. More research is needed to robustly evaluate the impacts quantitatively and/or qualitatively.
Coagulation Management of Critically Bleeding Patients With Viscoelastic Testing Presented as a 3D-Animated Blood Clot (The Visual Clot): Randomized Controlled High-Fidelity Simulation Study
Authors: Castellucci Clara , Malorgio Amos , Budowski Alexandra Dinah , Akbas Samira , Kolbe Michaela , Grande Bastian , Braun Julia , Noethiger Christoph B , Spahn Donat R , Tscholl David Werner , Roche Tadzio Raoul
Published: September 2023

Background

Guidelines recommend using viscoelastic coagulation tests to guide coagulation management, but interpreting the results remains challenging. Visual Clot, a 3D animated blood clot, facilitates interpretation through a user-centered and situation awareness–oriented design.

Objective

This study aims to compare the effects of Visual Clot versus conventional viscoelastic test results (rotational thrombelastometry [ROTEM] temograms) on the coagulation management performance of anesthesia teams in critical bleeding situations.

Methods

We conducted a prospective, randomized, high-fidelity simulation study in which anesthesia teams (consisting of a senior anesthesiologist, a resident anesthesiologist, and an anesthesia nurse) managed perioperative bleeding scenarios. Teams had either Visual Clot or ROTEM temograms available to perform targeted coagulation management. We analyzed the 15-minute simulations with post hoc video analysis. The primary outcome was correct targeted coagulation therapy. Secondary outcomes were time to targeted coagulation therapy, confidence, and workload. In addition, we have conducted a qualitative survey on user acceptance of Visual Clot. We used Poisson regression, Cox regression, and mixed logistic regression models, adjusted for various potential confounders, to analyze the data.

Results

We analyzed 59 simulations. Teams using Visual Clot were more likely to deliver the overall targeted coagulation therapy correctly (rate ratio 1.56, 95% CI 1.00-2.47; P=.05) and administer the first targeted coagulation product faster (hazard ratio 2.58, 95% CI 1.37-4.85; P=.003). In addition, participants showed higher decision confidence with Visual Clot (odds ratio 3.60, 95% CI 1.49-8.71; P=.005). We found no difference in workload (coefficient –0.03, 95% CI –3.08 to 2.88; P=.99).

Conclusions

Using Visual Clot led to a more accurate and faster-targeted coagulation therapy than using ROTEM temograms. We suggest that relevant viscoelastic test manufacturers consider augmenting their complex result presentation with intuitive, easy-to-understand visualization to ease users’ burden from unnecessary cognitive load and enhance patient care.