bluuebunny/crossref_metadata_2025 huggingface dataset:
An R2R3-type MYB transcription factor MYB103 is involved in phosphate remobilization in Arabidopsis thaliana
Authors: Yu Fangwei , Wang Shenyun , Zhang Wei , Wang Hong , Yu Li , Fei Zhangjun , Li Jianbin
Published: October 2019

Background The MYB transcription factor (MYB TF) family has been reported to be involved in the regulation of biotic and abiotic stresses in plants. However, the involvement of MYB TF in phosphate remobilization under phosphate deficiency remains largely unexplored. Results Here, we showed that an R2R3 type MYB transcription factor, MYB103, was involved in the tolerance to P deficiency in Arabidopsis thaliana . AtMYB103 was induced by P deficiency, and loss function of AtMYB103 significantly enhanced sensitivity to P deficiency, as root and shoot biomass and soluble P content in the myb103 mutant were significantly lower than those in wild-type (WT) plants under the P-deficient condition. Furthermore, the expression of Pi deficiency -responsive genes was more profound in myb103 than in WT. In addition, AtMYB103 may also be involved in the cell wall-based P reutilization, as less P was released from the cell wall in myb103 than in WT, which was in company with a reduction of the ethylene production. Conclusions These findings uncover the role of MYB103 in the P remobilization, presumably through ethylene signaling.
Microbiome insights into the perforated duodenal ulcer via metagenomic sequencing
Authors: Huang Xue , Ma Shaying , Niu Jingjing , Li Jiang , Wang Xiaoyu , Duan Xiangke , Yan Shuangquan , Xie Jianping
Published: October 2019

Background Perforated duodenal ulcer is a common condition. The associated microbiome and relationship with treatment success remain to be explored in addition to the well recognized role of Helicobacter pylori.Methods Metagenomic sequencing were used to profile the microbes underlying duodenal ulcer. The metagenome results of 6 duodenal ulcer samples (3 ulcer foci and 3 sites around the ulcer foci) were obtained and compared.Findings Ulcer patients and healthy control have different gut-type. Streptococcus mitis was highly enriched in duodenal ulcer patients.Interpretation The dysbiosis of microbiomes might underlie the duodenal ulcer, while the increased abundance of Streptococcus mitis is a novel finding. Whether there is causal link between S.mitis and duodenal ulcer remains to be determined.
Alternatively Activated Macrophages are the Primary Retinoic Acid Producing Cells in Human Decidua
Authors: Rajakumar Augustine , Kane Maureen A. , Yu Jianshi , Jones Jace W. , Qu Hongyan , Badell Martina , Taylor Robert N. , Sidell Neil
Published: October 2019

In situ production and metabolism of all-trans retinoic acid (RA) in decidual tissue are critically important for endometrial stromal differentiation, embryo implantation, and healthy placentation. However, the cellular source(s) of RA in this tissue has yet to be determined. To identify the primary RA-producing cells in human term decidua, we isolated cells from decidua basalis of delivered placenta and quantified cellular retinal dehydrogenase (RALDH) activity, a major biosynthetic enzyme whose activity determines the synthesis of RA from retinol, using an Aldefluor assay and flow cytometry. RA production in decidual tissue and sorted cell subpopulations was evaluated by liquid chromatography-tandem mass spectrometry. CD14+ cells (macrophages/monocytes) showed >4-fold higher RALDH activity than stromal cells (CD10+), T-cells (CD3+), or non-T lymphocytes (CD3-negative). CD11c+ cells that did not co-express CD14 showed about one-third the RALDH activity of their CD14 co-expressing counterparts. The highest RALDH activity was found in “alternatively activated” M2 macrophages delineated by the simultaneous expression of CD14 and CD163. The greater RA synthesizing capacity of M2 versus CD14+CD163-ve (M1) cells was confirmed by direct quantitation of RA biosynthesis from retinol. RA levels in whole decidua correlated with M2 cell density but not with stromal cell (CD10+) number, the major cell type comprising the decidua. These results identified M2 monocyte/macrophages as the primary source of RA in human term decidua. This finding may have implications for certain pregnancy complications that are known to be associated with reduced numbers of decidual M2 cells. Author note: This manuscript has been accepted for publication in the journal Reproductive Sciences
Results and lessons learnt from a randomized controlled trial: Prophylactic treatment of vestibular migraine with metoprolol (PROVEMIG)
Authors: Bayer Otmar , Adrion Christine , Tawil Amani Al , Mansmann Ulrich , Strupp Michael
Published: October 2019

BACKGROUND
Vestibular migraine (VM) is the most frequent cause of recurrent spontaneous attacks of vertigo causally related to migraine. The objective of the PROVEMIG trial was to demonstrate that metoprolol succinate is superior to placebo treatment in the prevention of episodic vertigo- and migraine-related symptoms in patients with VM.
METHODS
This phase 3, two-arm parallel-group, double-blind, randomized placebo-controlled trial was designed to be conducted at tertiary referral centres at neurology and ENT departments of eight German university hospitals. The planned sample size was a total of 266 patients to be allocated. Adults aged 18 years or above diagnosed with probable or definitive VM according to the Neuhauser criteria 2001 were randomly assigned 1:1 to six months blinded metoprolol (maintenance dosage of 95 mg daily) versus placebo treatment policy. The primary efficacy outcome was the self-reported number of vertiginous attacks per 30 days documented by means of a paper-based daily symptom diary. The pre-specified time period of primary interest was defined within month 4 to 6. Secondary outcomes included the patient-reported number of migraine days and vertigo days, the Dizziness Handicap Inventory and clinical assessments. Adverse events were reported throughout the whole 9-month study period.
RESULTS
At the time of trial termination, no evidence for a difference in the incidence of vertiginous attacks between both treatment groups was detected. For the full analysis set, the incidence rate ratio (IRR) was 0.983 (95% confidence interval (CI), 0.902 to 1.071) for metoprolol vs. placebo. In both groups, there was a significant decline over time in the overall monthly vertigo attacks by the factor 0.830 (95% CI, 0.776 to 0.887). Results were consistent for all subjective and objective key measures of efficacy. The treatment was well tolerated with no unexpected safety findings.
CONCLUSIONS
After randomizing 130 patients PROVEMIG had to be discontinued due to poor participant accrual not related to the tolerability of the study medication or safety concerns and no treatment benefit of metoprolol over placebo could be established. Additional preparatory work is much-needed in the development, psychometric evaluation and interpretation of clinically meaningful endpoints in trials on episodic syndromes like VM taking into consideration the complexity of this disease entity comprising of two domains (vertigo- and headache-related disability).
TRIAL REGISTRATION
EudraCT no 2009-013701-34, prospectively registered on 08 April 2011, https://www.clinicaltrialsregister.eu/ctr-search/trial/2009-013701-34/DE.
Human Cytomegalovirus Seroprevalence and Titres in Solid Organ Transplant Recipients and Transplant Donors in Seoul, South Korea
Authors: La Yeonju , Kwon Da Eun , Yoo Seul Gi , Lee Kyoung Hwa , Han Sang Hoon , Song Young Goo
Published: October 2019

Background: Human cytomegalovirus (HCMV) can cause poor outcomes in solid organ transplant (SOT) recipients; moreover, it is associated with cardiovascular diseases (CVD) in the general population. Accordingly, anti-HCMV immunoglobulin G (IgG) seroepidemiology may be useful in identifying the risk of post-SOT HCMV infection or disease as well as immunosenescence or CVD. However, HCMV seroprevalence and titre have not been fully evaluated with regard to age distribution or compared between SOT recipients and healthy individuals in South Korea.
Methods: We retrospectively retrieved all unduplicated anti-HCMV IgG results of individuals aged > 1 year evaluated between July 2006 and November 2017 at Severance Hospital in Seoul. The cohort, excluding haematopoietic stem cell transplant recipients and subjects with equivocal values, included 2184 SOT recipients and 3015 healthy transplant donors. All IgG results in the SOT recipients were measured during the pre-transplant period.
Results: The overall IgG seroprevalence and titres were significantly higher among SOT recipients than among healthy donors (98.7% vs. 88.6%, p < 0.001, and 64.7 ± 44.3 vs. 49.8 ± 20.6 arbitrary units/mL, p < 0.001, respectively). The lowest seropositive rate in the SOT group was observed in recipients aged between 11 and 15 years (70.6%). The frequency of seropositivity among adults aged ≥ 41 years increased to ≥ 90% in SOT recipients and healthy donors. Age was independently associated with higher HCMV seroprevalence (41–60 years, OR, 76.4, 95% CI, 24.5–238.9, p < 0.001; ≥ 61 years, OR, 4.4, 95% CI, 1.3–14.9, p < 0.001, compared to ≤ 40 years). The healthy donor group had an independently low HCMV seropositive rate (OR, 0.1, 95% CI, 0.1–0.2, p < 0.001).
Conclusions: HCMV seropositivity was the lowest among school-aged children and adolescents. IgG testing revealed an intermediate serostatus risk of post-transplant HCMV infection and disease for most adult SOT recipients in South Korea.
Variable versus constant frequency deep brain stimulation in patients with advanced Parkinson’s disease: study protocol for a randomized controlled trial
Authors: Jia Fumin , Zhang Jianguo , Wang Huimin , Liang Zhanhua , Liu Weiguo , Wang Xuelian , Liu Yiming , Guo Yi , Ling Zhipei , Cai Xiaodong , Wu Xi , Wu Jianjun , Lv Wen , Xu Xin , Zhang Wenbin , Li Luming
Published: October 2019

Background: Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) can be used to treat motor symptoms and dyskinesia in the advanced stages of Parkinson’s disease (PD). High frequency stimulation (HFS) of the STN can lead to consistent, long-term improvement of PD symptoms. However, the effects of HFS on the axial symptoms of PD, specifically freezing of gait (FOG), can be limited or cause further impairment. While this can be alleviated via relatively low frequency stimulation (LFS) in select patients, LFS does not control all motor symptoms of PD. Recently, the National Engineering Laboratory for Neuromodulation reported preliminary findings regarding an efficient way to combine the advantages of HFS and LFS to form variable frequency stimulation (VFS). However, this novel therapeutic strategy has not been formally tested in a randomized trial. Methods/Design: We propose a multicenter, double blind clinical trial involving 12 study hospitals and an established DBS team. The participants will be divided into a VFS and a constant frequency stimulation (CFS) group. The primary outcome will be changes in Stand-Walk-Sit (SWS) task scores at three months of treatment in the “medication off” condition. Secondary outcome measures include specific item scores on the Freezing of Gait Questionnaire and quality of life. The aim of this trial is to investigate the efficacy and safety of VFS compared with CFS. Discussion: This is the first randomized controlled trial to comprehensively evaluate the effectiveness and safety of VFS of the STN in patients with advanced PD. VFS may represent a new option for clinical treatment of PD in the future. Trial registration: The present protocol is registered at ClinicalTrials.gov: NCT03053726.
Prinsip-Prinsip Pemberdayaan Masyarakat Dalam Perspektif Al Qur’an
Authors: Sany Ulfi Putra
Published: October 2019

Becoming a challenge for every country and society, poverty is a problem that must be overcome. In Islam, it is also viewed as a disease that must be cured. One of the effective instruments of poverty alleviation is community empowerment. Community empowerment is methods used by individuals, groups and communities so they are able to manage the environment, achieve their own goals, work and help each other to maximize their quality of life. In the Qur'an there are many verses that speak about theme of community empowerment. This paper discusses community empowerment according to the Qur'anic perspective using thematic interpretation methods. The principles of community empowerment in the Qur'an are the principle of ukhuwwah, ta'awun principle, and the principle of equality. The steps of empowerment as mentioned in the Qur'an include continuous self-development, encouraging zakat and infaq programs, conducting training and skills education for the community, and avoiding economic behaviors prohibited by Islam such as hoarding and monopoly (ihtikar).

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Kemiskinan merupakan masalah yang harus diatasi dan menjadi tantangan bagi setiap negara dan masyarakat. Islam juga memandang kemiskinan sebagai penyakit yang harus disembuhkan. Karena kemiskinan dekat dengan kekufuran. Salah satu instrumen pengentasan kemiskinan yang efektif adalah dengan melakukan pemberdayaan masyarakat. Yang dimaksud dengan pemberdayaan masyarakat adalah cara dan metode yang digunakan individu, kelompok dan komunitas sehingga mereka menjadi mampu mengelola lingkungan dan mencapai tujuan mereka sendiri, dan dengan demikian mampu bekerja dan membantu satu sama lain untuk memaksimalkan kualitas hidup mereka. Dalam Al Quran terdapat banyak ayat yang membicarakan tema pemberdayaan masyarakat. Tulisan ini membahas pemberdayaan masyarakat menurut perspektif Al Qur’an dengan menggunakan metode penafsiran tematik. Prinsip-prinsip pemberdayaan masyarakat dalam Al Quran yaitu prinsip ukhuwwah, prinsip ta’awun, dan prinsip persamaan derajat. Langkah-langkah pemberdayaan sebagaimana disebutkan Al Qur’an antara lain pengembangan diri yang kontinyu, mendorong program zakat dan infaq, melakukan pembinaan dan pendidikan ketrampilan bagi masyarakat, dan tidak melakukan perilaku ekonomi yang dilarang oleh agama seperti menimbun  harta (hoarding) dan monopoli (ihtikar)
PERANAN DAKWAH Mr. SJAFRUDDIN PRAWIRANEGARA DALAM MENYELAMATKAN REPUBLIK
Authors: Sriyanto Sriyanto
Published: October 2019

Mr. Sjafruddin Prawiranegara is a unique figure in thinking and preaching. He was a great preacher and given contributions for republic .  Another learning, da'i should not be  prosecutor and judge. Sjafruddin role,  as a da’i the president often erased from history books. Based on this, Study entitled the role Sjafruddin Prawiranegara Dakwah in saving Republic  was carried out. This research very important because to re-read role of Mr. Sjafruddin Dakwah,  da'i warrior who has saved  existence and sustainability of Republic as part of his faith. This research is limited to role of his dakwah, biography, concept of struggle and  relevance his dakwah. This research is  qualitative as a library with  interpretative approach. The results of research indicate that his dakwah based on  strong Islamic worldview. Digest Dakwah  covering faith and reason is basis of preaching. " Greater reason dangerous for Islam than opponents openly hostile"  Sjafruddin said. The main role  Sjafruddin  dakwah was his courage and firmness to save Indonesia from  destruction defeat when the second military aggression. The role of his dakwah includes  all fields. His View thinks far ahead, so many still and remain relevant. He said that "preaching is inseparable from state and political matters"

.……..

Mr. Sjafruddin Prawiranegara adalah  tokoh yang unik dalam dakwahnya.  Dia adalah teladan  dan  sudah  memberi  sumbangsihnya  bagi  Republik. Pembelajaran  unik  dari    Sjafruddin yaitu;  seorang  da’i    seharusnya    tidak  menjadi jaksa dan hakim. Peranan  Sjafruddin  sebagai  dai yang presiden  sering  terhapus  dari  buku  sejarah Indonesia. Berdasarkan   hal   tersebut   maka   penelitian   berjudul   Peranan   Dakwah   Mr.   Sjafruddin Prawiranegara dalam menyelamatkan Republik dilaksanakan.   Penelitian ini sangat penting dilakukan karena membaca kembali peranan dakwah Mr.  Sjafruddin, seorang da’i    pejuang    yang  telah  menyelamatkan  keberadaan dan keberlangsungan Republik sebagai bagian imannya. Penelitian ini dibatasi pada peranan dakwahnya, biografi, konsep dan relevansi dakwahnya. Penelitian ini merupakan penelitian kualitatif.  Penelitian bersifat penelitian pustaka dengan pendekatan interpretasi. Hasil penelitian menunjukkan bahwa seluruh aktivitas dakwahnya didasari Islamic worldview yang kuat.  Iman dan akal merupakan dasar berdakwah. “Bahaya akal lebih besar bagi Islam dari lawan yang secara terang-terangan memusuhi  Islam”  kata  Sjafruddin; Peran utama dakwah Sjafruddin adalah keberanian dan ketegasannya dalam mengambil tindakan untuk mengambil alih menyelamatkan Indonesia dari kehancuran dan kekalahan ketika terjadi agresi militer Belanda ke-2.  Peranan dakwahnya mencakup semua bidang. Pandangannya  jauh  ke  depan, sehingga banyak pemikirannya yang masih dan tetap relevan di masa sekarang. Dia pernah berkata bahwa “berdakwah itu tidak bisa dilepaskan dari soal kenegaraan dan politik”.
USLŪB AL-DA’WAH DALAM PENAFSIRAN AL-QUR’AN
Authors: Safrodin Safrodin
Published: October 2019

Kajian ini bermaksud menjelaskan uslūb al-dakwah dalam penafsiran al-Qur’an. Salah satu alasan pentingnya kajian ini dikemukakan adalah bahwa dalam diskursus ilmu dakwah para sarjana dakwah sering menisbahkan uslūb al-dakwah yang prinsipil pada al-Nahl: 125. Ayat ini sering dinyatakan sebagai dalil tentang tiga macam uslūb al-dakwah secara berurutan, yakni (1) da’wah bi al-ḥikmah, (2) da’wah bi al-mau’idzah al-ḥasanah, dan (3) da’wah bi al-jidāl al-aḥsan. Pandangan ini sebenarnya masih menyisakan pertanyaan, yakni kalau dengan ketiga uslūb tersebut masyarakat (mad’ū) masih saja menolak dakwah Islam, lalu uslūb apa lagi yang harus digunakan oleh da’i ?. Untuk itu, kajian ini menggunakan metode kajian kepustakaan dengan analisis deskriptif dan komperatif. Kajian ini menyimpulkan bahwa dalam penafsiran al-Qur’an terdapat empat tahapan uslub dakwah yang prinsipil, yakni (1) da’wah dengan ḥikmah, (2) da’wah dengan mau’idzah ḥasanah, (3) da’wah dengan jidāl aḥsan, dan apabila ketiga cara tersebut masih belum bisa mengislamkan mad’ū, maka uslūb berikutnya adalah (4) berpaling dari mereka (al-i’rād ‘anhum). Komposisi uslūb al-dakwah ini melengkapi teori tentang tiga uslūb al-dakwah yang telah lama dipedomani oleh banyak sarjana dakwah.
Penerapan Cognitive Behaviour Therapy dalam Mengembangkan Kepribadian Remaja di Panti Asuhan
Authors: Aini Dewi Khurun
Published: October 2019

Penelitian ini bertujuan untuk mengetahui proses dan respon pelaksanaan “Pendekatan Brainology dan Psikologi Positif (CBT)” dalam mengembangkan kepribadian remaja putri yang berada di panti asuhan Aisyiyah Ronggowarsito Semarang. Penelitian ini melibatkan 30 responden remaja putri Panti Asuhan Aisyiyah sebagai subjek penelitian. Metodologi penelitian pada kajian ini adalah participatory action research. Metodologi ini merupakan salah satu model penelitian yang mencari sesuatu untuk menghubungkan proses penelitian ke dalam proses perubahan sosial. Perubahan sosial yang dimaksud adalah bagaimana dalam proses pemberdayaan dapat mewujudkan tiga tolak ukur, yakni adanya komitmen bersama dengan masyarakat dan adanya institusi baru dalam masyarakat yang dibangun berdasarkan kebutuhan. Sementara, untuk hasil dalam penelitian ini menggunakan pendekatan kualitatif dengan analisis data, data yang sudah terkumpul dibuat dalam matriks, analisisi ini disebut analisis interaktif. Dalam matriks akan disajikan penggalan-penggalan data deskriptif sekitar peristiwa atau pengalaman masyarakat tertentu. Tahapan-tahapan analisisnya berupa pengumpulan data (data collection), reduksi data (data reduction), penyajian data (data display), penarikan kesimpulan (conclutions). Hasil penelitian menunjukkan Program pengembangan kepribadian remaja putri yang berada di panti asuhan dengan pendekatan Cognitive Behaviour Therapy dapat meningkatkan kemampuan kognitif dan perilaku subjek penelitian. Subjek penelitian melakukan interaksi sosial dengan baik, sehingga subjek penelitian tetap menjaga hubungan atau kontak sosial, sehingga subjek penelitian merasa tidak sendiri. Kepribadian remaja putri panti semakin berkembang menjadi lebih baik.
Eduardo Viveiros de Castro: “En Brasil, todos son indios, excepto quien no lo es”
Authors: De Castro Eduardo Viveiros , Figueroa Isabela , Piraquive Margarita
Published: October 2019

En 26 de abril de 2006, Eduardo Viveiros de Castro – profesor de Antropología en el Museo Nacional (Rio de Janeiro) y especialista en Etnología Brasilera – estuvo en el Instituto Socioambiental (ISA) de São Paulo para hablar con los editores de Povos Indígenas no Brasil, sobre dos cuestiones polémicas: ¿Quién es indio? y ¿qué es lo que define la pertenencia a una comunidad indígena?  [Lo que sigue es la entrevista].
En honor al profesor Enrique Campo Mier
Authors: Duran Gamarra Hugo David
Published: October 2019

“Llegó el arqueólogo más prolífico de la región Caribe” así era recibido en la Facultad de Humanidades de la Universidad del Magdalena el profesor Enrique Campo Mier, antropólogo de la Universidad de Antioquia y especialista de la Universidad del Magdalena (Unimagdalena).
Glosa krytyczna do wyroku Sądu Apelacyjnego w Białymstoku z 22.6.2015 r. (sygn. akt II Aka 70/15)
Authors: Kencel Anna
Published: October 2019

Artykuł stanowi analizę rozstrzygnięcia Sądu Apelacyjnego w Białymstoku z 22.6.2015 r. (sygn. akt II AKa 70/15) oraz jego uzasadnienia w przedmiocie ustalania zamiaru sprawcy zbrodni zabójstwa, a także odpowiedniej kwalifikacji prawnej czynu zabronionego. Autorka krytykuje stanowisko sądu, który pomimo licznych wątpliwości rozstrzygnął na niekorzyść sprawcy dopuszczającego się, w jego ocenie, zbrodni zabójstwa, podczas gdy analiza stanu faktycznego wskazywała na realizację znamion przestępstwa stypizowanego w art. 156 § 3 Kodeksu karnego. Krytyce zostało poddane także dokonanie rozstrzygnięcia wyłącznie w oparciu o okoliczności przedmiotowe zdarzenia, jak również uzasadnianie strony woluntatywnej istnieniem strony intelektualnej. Jednocześnie autorka akcentuje podobieństwo zachodzące pomiędzy stroną intelektualną zamiaru ewentualnego oraz stroną intelektualną świadomej nieumyślności.
Wina w organizacji jako przesłanka odpowiedzialności podmiotu zbiorowego w świetle projektowanej ustawy o odpowiedzialności podmiotów zbiorowych
Authors: Jóźwiak Ida
Published: October 2019

Projektowana ustawa o odpowiedzialności podmiotów zbiorowych wprowadza do polskiego porządku prawnego stosunkowo nową podstawę odpowiedzialności, jaką jest wina w organizacji. W porównaniu z obecnie obowiązującą ustawą, zmieniają się przesłanki uznania organizacji przedsiębiorstwa za nieprawidłową, jak również prowadzanejest novum w postaci otwartego katalogu przykładowych nieprawidłowości, który potęguje wątpliwości interpretacyjne związane z rozumieniem pojęcia winy w organizacji. Do celu wykładni pojęcia nieprawidłowości w organizacji przydatne może być porównaniesposobu organizacji podmiotu zbiorowego ze swoistym modelem „należytej” dla danego podmiotu zbiorowego organizacji, z uwzględnieniem jego rozmiaru i przedmiotu działalności, podobnie jak ma to miejsce w przypadku wykładni pojęcia należytej staranności. Tworzenie takiego modelu może być jednak kłopotliwe, ponieważ w pierwszej kolejności wymaga określenia optymalnej (z punktu widzenia zapobiegania naruszeniom przepisów prawa) struktury organizacyjnej podmiotu zbiorowego, a następnie oceny związku między sposobem organizacji podmiotu zbiorowego a możliwością lub łatwością popełnieniaczynu zabronionego.
Intracellular and Extracellular Zinc Detection by Organic Fluorescent Receptor
Authors: Hanif Muhammad , Rafiq Muhammad , Mustaqeem Muhammad , Shaheen Muhammad A. , Qadri Kaneez F. I. , Qadri Ishtiaq , Saleem Muhammad
Published: October 2019

Keeping in view the ever growing demand and application of the organic small
molecules based sensitive and selective fluorescence detection strategies for the trace metallic
ions in the ecosystem, fluids and inside intracellular media, the present literature
survey was focused on the recent development on the organic skeleton based fluorescence
sensor for the zinc ion as Zn2+ is the second most abundant transition metal after iron in
human body. The prominent organic based skeletons introduced during the past three
years for zinc detection including azine, ((Z)-N´-(quinolin-2-ylmethylene)furan-2-
carbohydrazide), nicotinohydrazide, hydrazone, phenolic cage, 4-methyl-2,6-bis[(E)-(2-
(4-phenylthiazol-2-yl)hydrazono)methyl]phenol, bipyridine, N-(quinoline-8-yl)pyridine-2-
carboxamide, anthracene, Schiff base, salen, helicene, Carbon Quantum Dots (CDs) functionalized
with Calix[4]arene, coumarin, diaminomaleonitrile, peptide, hydroxypyrazole, salicylhydrazide were
discussed in detail with particular focus on ligand-zinc complexation mechanism, UV-visible and fluorescence
investigation, spectral variation, isosbestic emergence, limit of detection, ligand-zinc binding stoichiometry,
association/binding constant and applications for intracellular tracing of metallic contamination via confocal
fluorescence microscopic studies. Among the several discussed optical probes, rhodamine and fluorescein
based material offer appreciable sensitivity, exhibiting drawback of pH sensitivity. Probes based on these
ligands triggered “turn-on” signal even in the absence of metals upon fluctuation in pH e.g., acidic in former
case and basic in the latter case. Hydroxypyrazole-based ligands also showed detection signal variation by
switching the pH of the solution. Schiff base and bipyridyl scaffold were found to possess good ligation toward
the several transition metals. Azole, oxazole, thiazole, thiadiazole, hydrazine carboxamide and hydrazine carbothiomide
are the bioactive molecules exhibiting good cell viability and probes designed by using these central
nucleus might be better to invest for intracellular imaging. Symmetrical heterocyclic cage like probe
showed better chelation toward several transition metals and it is a good choice for the design and development
of sensor for simultaneous detection of several transition metals.
Epigenetics, Gender, and Sex in the Diagnosis of Depression
Authors: Mehl-Madrona Lewis , McFarlane Patrick , Mainguy Barbara
Published: October 2019

Background :

A marked sexual dimorphism exists in psychiatric diagnoses. Culture derived gender bias in diagnostic criteria is one explanation. Adverse childhood events, including sexual and physical abuse, are more reliable and consistent predictors of later psychiatric diagnoses, including depression and post-traumatic stress disorder. Some interesting interactions between genes and experience have been uncovered, but the primary effect appears to be epigenetic with life experience altering gene expression and being transmitted to subsequent generations.

Objectives :

To determine if reconceptualizing depression as encompassing both internalizing and externalizing strategies would eliminate gender differences in the diagnosis of depression

Methods :

We reviewed 74 life stories of patients, collected during a study of the effect of physicians’ knowing patients’ life stories on the quality of the doctor-patient relationship. Looking at diagnoses, the prevalence of women to men was 2.9 to 1. We redefined depression as a response to being in a seemingly hopeless situation accompanied by despair, either externalizing ((more often diagnosed as substance use disorders, impulse control disorders, antisocial personality disorder, or bipolar disorder) or internalizing (the more standard diagnosis of depression). Then we reviewed these life stories from that perspective to determine how many would be diagnosed as depressed.

Results :

With this reconceptualization of depression, the sex ratio changed to 1.2 to 1.

Conclusions:

From this perspective, men and women are equally likely to respond to hopelessness, though men are more socialized to externalize and women to internalize. Considering depression in this way may help to better identify men at risk for suicide.
РОЛЬ НАУКОВО-ДОСЛІДНОЇ РОБОТИ СТУДЕНТА У ФОРМУВАННІ МАЙБУТНЬОГО ФАХІВЦЯ
Authors: Готюр О. І. , Деніна Р. В. , Волинскьий Д. А. , Кочержат О. І.
Published: October 2019

Резюме. Науково-дослідна робота студентів (НДР) є невід’ємною складовою наукової діяльності кожного університету України і першим етапом у підготовці наукових кадрів, що зазвичай реалізується на кафедрах (студентські наукові гуртки) і в наукових структурних підрозділах університету (студентське наукове товариство) або на території лікувальних закладів.

Основними завданнями науково-дослідної роботи студентів Івано-Франківського національного медичного університету є: залучення талановитої молоді до наукових досліджень, організація участі студентів в конкурсах студентських наукових робіт, студентських наукових конференціях, олімпіадах. Наукова робота студентів ІФНМУ здійснюється за загальновідомою схемою наукового аналізу. Керівництво НДР студентів здійснюють науково-педагогічні працівники університету. Їхнім основним завданням є допомога студентові в процесі опанування основ наукового пошуку, наданні консультацій та здійсненні контролю за виконанням роботи на всіх її стадіях. В ході НДР керівник допомагає обрати тему, сформулювати мету і завдання, рекомендує найважливішу літературу та джерела з проблематики роботи, оцінює зміст тексту у його окремих складових та у цілому, рекомендує внесення правок і доопрацювання певних частин роботи.

Система науково-дослідної роботи є важливою складовою професійної підготовки майбутнього фахівця. Вона повинна бути спрямована на формування особистості медичного працівника, який, використовуючи набуті у вищій школі проектувальні (уміння планувати будь-який вид роботи), адаптаційні (уміння застосувати даний план у конкретних умовах), організаційні, мотиваційні, комунікативні, пізнавальні уміння, таким чином підвищить свою конкурентоспроможність на ринку праці.
Anais da XXXVIII Semana Médica, XV COMA - Congresso Médico Acadêmico e X Congresso de Iniciação Científica - 7 A 11 DE MAIO DE 2018
Authors: Organizadora Comissão
Published: October 2019

Caros Congressistas, Em 2018, a Faculdade de Medicina da Itajubá comemora o seu Jubileu de Ouro, meio século de existência. É uma data linda que merece todas as comemorações. E dentre elas, é com imensa satisfação, que anunciamos a 38ª Semana Médica de 7 a 11 de maio, juntamente com o XV Congresso Médico Acadêmico – COMA e o X Congresso de Iniciação Científica, todos preparados com muita qualidade e critério. Desejamos que nosso evento seja representativo de todas as áreas de saúde, e para tanto, procuramos organizá-lo priorizando os temas de interesse dos alunos e trazendo os ex-alunos á sua casa. Além do excelente programa científico, teremos também as iniciativas que estimulam o convívio e a cultura, como a Confraternização de Encerramento e o Show Med 2018. Mais uma vez, contamos com o apoio imprescindível de nossos patrocinadores, sem o qual não era possível fazer um evento com esta dimensão. Esperamos contar com a sua presença para que, juntos, possamos viabilizar as atividades científicas e culturais deste acontecimento! Sejam bem-vindos e bem-vindas Comissão Organizadora
A Passivity Approach to the Stabilization of Free-Radical Polymerization Reactor
Authors: Sang Nguyen T. , Ha Hoang N. , Hussain M.A.
Published: October 2019

This work proposes a tracking error passivity-based multivariable control viafeedback passivation for a class of free-radical polymerization systems in a continuouslystirred tank reactor (CSTR). Firstly, this system dynamics with high nonlinearity ispassivized by input coordinate transformations, the resulting passive system is then rewritten into a canonical form strongly related to the so-called Port Control Hamiltonianstructure. Actually, this representation allows to show the physical meanings of systemdynamics such as dissipative, non-dissipative terms and supply rate. From this, a feedbackcontroller based on tracking error is designed for the globally exponential stabilization atan arbitrarily chosen reference trajectory passing the desired equilibrium point. Thetheoretical developments are then illustrated for polystyrene polymerization system inthe CSTR. The numerical simulations show that the trajectories of styrene polymerizationsystem considered as an illustrative example of FRP system converges globallyexponentially to the imposed trajectories.
The Effect of Temperature on Extraction of Swietenia Mahagoni by Ultrasound–assisted Extraction (UAE) Method
Authors: Febriana Ike Dayi , Kusuma Heri Septya , Galan Selfina , Mahfud Mahfud
Published: October 2019

Azo dyes are synthetic organic dyes which have azo group (-N=N-) as chromophore. Waste of azo dyes have not been able to overcome completely so that requires solutions of natural dye. Raw material of natural dye can be obtained from Swietenia mahagoni. Natural dye can be extracted by ultrasound-assisted extraction (UAE) method. The pupose of this research is to study the factor that influence UAE. Observed factor is influence of extraction temperature to the yield of natural dye. This research was conducted using ratio of material to solvent of 0.05 g/L with extraction time at 40 minute. Extraction temperature was observed at 30, 40, and 50oC. Ultrasonic wave that used for this research at 40 kHz. The result is increasing temperature will be allow the increasing trend of yield. The result indicate that there is about 9.2748% improvement in the yield of extract due to increasing extraction temperature from 30oC to 50oC
Mechanical and Thermal Properties of Geopolymers from Mixtures of Coal Ash and Rice Hull Ash using Water Glass Solution as Activator
Authors: Kalaw Martin Ernesto L. , Culaba Alvin B , Nguyen Hoc Thang , Nguyen Khoi , Hinode Hirofumi , Kurniawan Winarto , Gallardo Susan M , Promentilla Michael Angelo B.
Published: October 2019

Geopolymers, from industrial wastes such as blast furnace slag, red mud, and coal ash, among others, have emerged as technically viable, economically competitive, and environmentally attractive supplements and even alternatives to ordinary Portland cement (OPC). Furthermore, while the most impact shall be achieved with large-scale use in the general building and structural sector, as replacement or supplement to OPC, the properties of these geopolymers may be optimized for special niche applications. One of these applications is for light weight, low thermal conductivity, heat resistant, and moderate strength cement binder for low rise residential buildings. In this study, compressive strength, heat resistance, volumetric weight, mass loss, water absorption and thermal conductivity of geopolymers formed from mixtures of coal bottom ash and rice hull ash (CBA-RHA) and coal fly ash and rice hull ash (CFA-RHA) with sodium silicate solution (modulus 2.5) as activator were evaluated. Using mixture design and the JMP statistical software, the CBA-RHA combination at a mass ratio of 46% CBA, 32% RHA with 22% WGS gave properties at maximum desirability of 17.6 MPa compressive strength, 1640 kg/m3 volumetric weight, 273 kg/m3 water absorption, 28 MPa compressive strength after high temperature exposure (1000oC for 2 hours) with 4.4% mass loss, and 0.578 W/m-K thermal conductivity. On a performance basis, even as the geopolymers are formed as paste, these properties fall within the standards for lightweight OPC based-concrete with strength requirements for residential buildings. The low thermal conductivity and higher strength after high temperature exposure vis-à-vis OPC are additional advantages for consideration.
Forward Osmosis: Temperature Effects By Using Pome as Feed Solution
Authors: Arifin Hanizah , Choong Thomas S.Y. , Rong Chan Kam , Ahmadun Fakhru'l Al-Razi , Abdullah Luqman Chuah
Published: October 2019

Forward osmosis (FO) has recently been considered as one of the promising technologies for low energy applications. Factors that influence FO performance are draw solution, types of membrane, membrane orientation, cross flow velocity, module configuration and temperature effect. In this study, the influence of temperature on the performance of FO process has been studied in terms of water flux by using raw POME as feed solution. A higher temperature creates a higher water fluxes at various draw solution concentrations. Percentages of water flux increments for raw POME are between 7% to 9% from 25ºC to 35ºC and 32% to 75% from 25ºC to 45ºC.
A Skeletal Kinetic Model For Biodiesel Fuels Surrogate Blend Under Diesel-Engine Conditions
Authors: Oo Chit Wityi , Shioji Masahiro , Kawanabe Hiroshi , Roces Susan A. , Dugos Nathaniel P.
Published: October 2019

The biodiesel surrogate fuels are realistic kinetic tools to study the combustion of actual biodiesel fuels in diesel engines. The knowledge of fuel chemistry aids in the development of combustion modeling. In order to numerically simulate the diesel combustion, it is necessary to construct a compact reaction model for describing the chemical reaction. This study developed a skeletal kinetic model of methyl decanoate (MD) and n-heptane as a biodiesel surrogate blend for the chemical combustion reactions. The skeletal kinetic model is simply composed of 45 chemical species and 74 reactions based on the full kinetic models which have been developed by Lawrance Livermore National Laboratory (LLNL) and Knowledge-basing Utilities for Complex Reaction Systems (KUCRS) under the diesel like engine conditions. The model in this study is generated by using CHEMKIN and then it is used to produce the ignition delay data and the related chemical species. The model predicted good reasonable agreement for the ignition delays and most of the reaction products at various conditions. The chemical species are well reproduced by this skeletal kinetic model while the good temperature dependency is found under constant pressure conditions 2MPa and 4MPa. The ignition delay time of present model is slightly shorter than the full kinetic model near negative temperature coefficient (NTC) regime. This skeletal model can provide the chemical kinetics to apply in the simulation codes for diesel-engine combustion.
Thermodynamic Modelling of Gas Hydrate Formation in the Presence of Inhibitors and the Consideration of their Effect
Authors: Sabzi Peyman , Noroozi Saheb
Published: October 2019

Gas hydrates formation is considered as one the greatest obstacles in gas transportation systems. Problems related to gas hydrate formation is more severe when dealing with transportation at low temperatures of deep water. In order to avoid formation of Gas hydrates, different inhibitors are used. Methanol is one of the most common and economically efficient inhibitor. Adding methanol to the flow lines, changes the thermodynamic equilibrium situation of the system. In order to predict these changes in thermodynamic behavior of the system, a series of modelings are performed using Matlab software in this paper. The main approach in this modeling is on the basis of Van der Waals and Plateau's thermodynamic approach. The obtained results of a system containing water, Methane and Methanol showed that hydrate formation pressure increases due to the increase of inhibitor amount in constant temperature and this increase is more in higher temperatures. Furthermore, these results were in harmony with the available empirical data.Keywords: Gas hydrates, thermodynamic inhibitor, modelling, pipeline blockage
The Initial Dioxigenase Gene Squences Analysis of Marine Bacteria Strain M128
Authors: Sahlan Muhamad , Yuliani Hanif , Hermansyah Heri , Wijanarko Anondho
Published: October 2019

Biodegradation of polyaromatic hydrocarbons (PAHs) are catalyzed by multicomponent enzymes from microbe. The initial dioxygenase was used as a key enzyme for attacking the aromatic ring structure of PAHs, furthermore its initial dioxygenase gene was used to select PAHs degrading bacteria. Marine bacteria M128 strain could grow on medium contained PAHs. Detection of its cellular initial deoxygenase gene was done by nahAc gene amplification. The nahAc gene commonly used as biomarkers of PAH degradation, and as a result, nahAc gene sequence analysis of marine bacteria M128 strain was similar to naphthalene dioxygenase of Pseudomonas genera with 99% homology.
Synthesis of Ternary Homogeneous Azeotropic Distillation Sequences: 2. Flowsheet Identification
Authors: Sutijan Sutijan , Jobson Megan , Smith Robin
Published: October 2019

This paper presents a systematic methodology for flowsheet generation for separating binary azeotropic mixtures using homogeneous azeotropic distillation. A new classification system for ternary mixtures using ‘standard distillation line maps’ defined in Sutijan et al. (2012) is employed. The new characterisation system is able to link candidate entrainers to flowsheet structures which can facilitate the separation. The sequences considered include pressure-swing distillation, two and three-column flowsheets with or without boundary crossing and the use of single and double-feed columns. For a given ternary mixture, suitable flowsheet structures that can facilitate the separation can be automatically identified. The method is illustrated using examples.
Design and Control of Alkali-Catalyzed Transesterification Reactors
Authors: Lersbamrungsuk Veerayut , Srinophakun Thongchai
Published: October 2019

Controllability analysis during the design stage is needed to ensure that the plant can be operated properly. This research focuses on design and control of transesterification reactor. Effects of important design parameters including residence time, methanol/oil molar ratio, and reactor temperature to design conversion and controllability of the reactor are studied. Controllability is analyzed using linear system theory based on poles, zeros, and gains. The result reveals that for a given design conversion, the operation with high reactor temperature and low methanol/oil molar ratio is preferred.
A Dynamic Model for Ultrasonic – assisted Extraction of Bio-active Compounds from Natural Products
Authors: Tran Trung Kien , Phung Lan Huong , Le Hoai Nga , Nguyen Thi Thu Huyen , Nghiem Xuan Son , Pham Van Thiem
Published: October 2019

Ultrasonic technique has been applied for extraction processes, especially for separation of bio-active substances from natural organic products because of the short time requirement, energy saving and easy operating. The ultrasonic-assisted extraction (UE) therefore becomes a promising option. However, a major available obstacle was the lack of appropriate models for designing technological process. This paper presents a dynamic model for the UE process, application of separation of bio-active substances from natural products such as Curcumin from rhizome of Curcuma Longa L., Epigallocatechin from green tea leaf of Camellia Sinensis and Rutin from bud of Sophora Japonica. The agreement between data from experiment and calculated ones with the model indicates that, this dynamic model is suitable for prediction of the UE process and for serving as the base for further investigation into scale-up the extraction process.
Optimization Research into the Ultrasonic-assisted Extraction to Separate Polyphenol from Green Tea Waste
Authors: Phung Lan Huong , Tran Trung Kien , Nguyen The Cuong , Do Hong Quang , Phan Thu Tra , Vu Hong Son , Nguyen Tien Huy
Published: October 2019

Today, green tea leaves (Camellia sinensis) have been grown in nearly 30 provinces in Vietnam. Catechins, which are polyphenols, are abundant in green tea. In a freshly picked tea leaf, polyphenols can compose up to 30% of the dry weight. Recently, researchs have focused on tea polyphenols due to its potent anti-oxidant activity, anti-inflammatory and anti-cancer effects. Viet Nam currently ranks the fifth in the world in tea production and export turn-over. However, green tea is made from the top two leaves and buds of a shrub. A large amount of stems, older leaves and tea wastes from tea factories is not produced. For this reason, study to separation polyphenols from these materials plays an important role in science, society and economy. Polyphenols can be extracted from green tea leaves by using hot water and organic solvents. In the method of using hot water, green tea quality deteriorates and catechins are destroyed due to the heat applied. Therefore, we attempted to increase the amount of polyphenols in extracts with using ultrasonic irradiation at low temperature. This work has an aim to investigate the influent process parameters such as extraction time, stirring speed and the rate of raw material/solvent on efficiency of the extraction of polyphenols and antioxidant properties obtained extracts. The ultrasonic-assisted extraction was conducted at room temperature, ultrasound frequency (25 kHz) using water solvent. Extracts were analysed for total phenols content (TPC) by the Lowenthal method. The antioxidant properties have been determined by DPPH free radical scavenging effect, The results of the work are the basis to determine of the optimal technological factors by employing desirability methodology with experimental order of Box-Behnken design and to scale up for designed industrial extraction system that can be applied in tea plants for the production of tea polyphenols from tea wastes.
CO2 Selective Water Gas Shift Membrane Reactor : Modeling and Simulation
Authors: Wirawan Sang Kompiang , Creaser Derek , Bendiyasa I Made , Sediawan Wahyudi Budi
Published: October 2019

The concept of a CO2 selective water gas shift (WGS) membrane reactor has been modeled and simulated by a one-dimensional reactor and transport process in the membrane. The model was used to investigate the effect of temperature, total pressure, membrane thickness and area on the reactor performance. A Silicalite-1 membrane was considered to be integrated with the WGS reactor. The mass transport through the membrane was described by surface diffusion. Air was used as sweep gas on the permeate side of the membrane. The catalytic WGS kinetics were for a commercial Cu/ZnO catalyst for the lower-temperature WGS reaction. The WGS membrane reactor was sized to produce H2 sufficient for the production of 10 kW electrical power from a fuel cell. The modeling and simulation results showed that the WGS membrane reactor with a silicalite-1 membrane was capable of decreasing the CO concentration to about 675 ppm which is 70% less than that achievable at equilibrium conversion, but it would come at the cost of unacceptable H2 loss. Based on a minimum target of H2 loss, the optimum outlet CO concentration achieved by the silicalite-1 membrane reactor was about 1310 ppm, under a range of limited conditions. The modeling study showed that both the WGS reaction rate and the CO2/H2 selective permeation played an important role on the overall reactor performance.
Analysis of Control Valves Stiction Quantification Tool
Authors: Zabiri H. , Elarafi M Gaberalla M K
Published: October 2019

Control valve stiction is considered as one of the main sources of control loops nonlinearities which impacts plants profitability. In turn, this phenomenon hinders the plant from being operated at optimal conditions. Therefore, an efficient and accurate stiction quantification algorithm is required for accurate stiction compensation and timely scheduling of control valve maintenance. This research investigates the robustness and recommends improvements to the previously developed stiction quantification approach by Zabiri et al. The approach was tested under several operating conditions which were simulated in five case studies by using MATLAB software. The case studies investigated the impact of a wide range of stiction values, controller tuning, disturbance, time delay and noise on the quantification approach. The algorithm was found to be robust since it quantified the correct values of stiction regardless of the operating conditions. It was found that the accuracy of the quantification results depends on the process model accuracy, number of data samples and the search resolution. A number of improvements were recommended and validated by simulation in order to further enhance the current quantification approach. As conclusion, the algorithm can be applied on any type of process due to its robustness.