bluuebunny/crossref_metadata_2025 huggingface dataset:
Jump-Diffusion Models for Valuing the Future: Discounting under Extreme Situations
Authors: Masoliver Jaume , Montero Miquel , Perelló Josep
Published: July 2021

We develop the process of discounting when underlying rates follow a jump-diffusion process, that is, when, in addition to diffusive behavior, rates suffer a series of finite discontinuities located at random Poissonian times. Jump amplitudes are also random and governed by an arbitrary density. Such a model may describe the economic evolution, specially when extreme situations occur (pandemics, global wars, etc.). When, between jumps, the dynamical evolution is governed by an Ornstein–Uhlenbeck diffusion process, we obtain exact and explicit expressions for the discount function and the long-run discount rate and show that the presence of discontinuities may drastically reduce the discount rate, a fact that has significant consequences for environmental planning. We also discuss as a specific example the case when rates are described by the continuous time random walk.
Diagnosis of Laryngeal Pemphigus Vulgaris Can Be Facilitated Using Advanced Endoscopic Methods
Authors: Staníková Lucia , Formánek Martin , Hurník Pavel , Kántor Peter , Komínek Pavel , Zeleník Karol
Published: July 2021

Background: Isolated laryngeal pemphigus vulgaris (LPV) is rare; however, early diagnosis is crucial in determining its course and prognosis. This paper aims to describe mucosal vascular changes typical for LPV using advanced endoscopic methods, which include Narrow Band Imaging (NBI), IMAGE1-S video-endoscopy and enhanced contact endoscopy (ECE). Materials and Methods: Retrospective analysis of all laryngeal mucosal lesion examined using advanced endoscopic methods during 2018–2020 at tertiary hospital was performed. Results: Videolaryngoscopy examination records of 278 patients with laryngeal mucosal lesions were analyzed; three of them were diagnosed with LPV. Epithelial vascularization of LPV included specific pattern. Intraepithelial papillary capillary loops were symmetrically stratified and were organized into “contour-like lines”. This specific vascularization associated with LPV were different from other laryngeal mucosal pathologies. Conclusions: Using advanced endoscopic methods supports early diagnosis of LPV and accelerate the diagnosis and treatment.
Correlation between the Korean Version of the Trunk Control Measurement Scale and the Selective Control Assessment of the Lower Extremity Scores in Children with Cerebral Palsy
Authors: Lim Misoo , Lee Haneul , Lim Hyoungwon
Published: July 2021

Background and Objectives: The purpose of this study was to investigate the correlation between the Korean version of the trunk control measurement scale (K-TCMS) and the selective control assessment of the lower extremity (SCALE). Through this, we tried to find out the effect of proximal stabilization on distal motor development. Materials and Methods: Fifty-one children with gross motor function classification system level I–III, diagnosed with cerebral palsy (CP), were studied. The K-TCMS was used to evaluate the body control ability of the children. SCALE was used to quantify selective voluntary motor control (SVMC). Results: Analysis of SCALE and K-TCMS showed a significant positive correlation in all items. Multiple regression analysis showed that the SCALE score decreased as age increased, and that it increased as the static sitting balance ability score and the dynamic sitting balance ability score of the K-TCMS increased significantly (p < 0.05). Conclusions: In children with cerebral palsy, there was a close correlation between trunk control and selective voluntary motor control of the lower extremities. Therefore, when trying to improve the lower extremity function of a child with cerebral palsy, a trunk control intervention should be considered.
Quantitative Understanding of the Environmental Effect on B10 Copper Alloy Corrosion in Seawater
Authors: Cai Yikun , Xu Yuanming , Zhao Yu , Zhang Weifang , Yao Jinghua , Wei Mumeng , Zhou Kun , Ma Xiaobing
Published: July 2021

Corrosion in natural seawater is difficult to simulate in a laboratory due to the slow rate and complexity of the corrosion process which involves multiple influential factors. This paper aims to explore the quantitative effect of environmental factors on corrosion process and find the best experimental conditions which represent the actual environment and have the best acceleration effect. A new framework is followed in this paper which consists of three parts: design of experiments, outdoor and laboratory corrosion tests, and corrosion mechanism consistency confirmation. A L6(31 × 22) orthogonal experiment is designed in laboratory to study the effect of temperature, salinity, and dissolved oxygen on marine corrosion behavior of B10 copper alloy. In each test, H2O2 is added in seawater to accelerate the corrosion process. Outdoor exposure tests are also conducted in natural seawater. Results show that the corrosion process in laboratory and outdoor follows the same mechanism, in view of corrosion product and morphology, corrosion kinetics, as well as mechanical properties. With the help of quantitative analysis of the test results, a better acceleration condition can be designed.
Spheroidisation of Stainless Steel Powder for Additive Manufacturing
Authors: Chikosha Silethelwe , Tshabalala Lerato C. , Bissett Hertzog , Lesufi Miltia , Mnguni Ndumiso K. , Motsai Tebogo M. , Manama Thabiso , Hoosain Shaik
Published: July 2021

In additive manufacturing, powder characteristics play an important role in terms of flowability and densification, which can be improved by the use of spherical powders. In this study, irregular powder was spheroidised by plasma treatment, and the powder properties were measured. Powder characterisation was conducted to determine the morphology, particle size and distribution as well as the flowability. Spherical AISI 304 stainless steel powders were produced by plasma spheroidization, and the efficiency of the spheroidisation process was evaluated. The spheroidisation process resulted in 93% efficiency with a decrease of fine particles (<63 µm) by 22%, while the all the flowability parameters of the powder improved significantly.
Sequence and Gene Expression Analysis of Recently Identified NLP from Plasmopara viticola
Authors: Askani Lars , Schumacher Stefan , Fuchs René
Published: July 2021

Grapevine downy mildew, evoked by the obligate biotrophic oomycete Plasmopara viticola, is one of the most challenging diseases in viticulture. P. viticola establishes an infection by circumvention of plant immunity, which is achieved by the secretion of effector molecules. One family of potential effectors are the necrosis- and ethylene-inducing peptide 1 (Nep1)-like proteins (NLP). NLP are most abundant in plant pathogenic microorganisms and exist in cytotoxic and non-cyctotoxic forms. Cytotoxic NLP often act as virulence factors and are synthesized in necrotrophic or hemibiotrophic pathogens during the transition from biotrophic to necrotrophic growth. In addition to these cytotoxic NLP, many non-cytotoxic NLP have been identified; their function in biotrophic pathogens is still unknown. In 2020, eight different NLP coding genes were identified in P. viticola and named PvNLP1 to PvNLP8 (Plasmopara viticolaNLP 1–8). In the present study, PvNLP4 to PvNLP8 were characterized by using qPCR analysis and transient expression in the model plant Nicotiana benthamiana. Gene expression analysis showed high PvNLP expression during the early stages of infection. Necrosis-inducing activity of PvNLP was not observed in the nonhost N. benthamiana.
Uraninite from the Guangshigou Pegmatite-Type Uranium Deposit in the North Qinling Orogen, Central China: Its Occurrence, Alteration and Implications for Post-Caledonian Uranium Circulation
Authors: Wu Bin , Bonnetti Christophe , Liu Yue , Zhang Zhan-Shi , Guo Guo-Lin , Li Guang-Lai , Hu Yin-Qiu , Yan Zhao-Yan
Published: July 2021

The Guangshigou deposit is the largest pegmatite-type uranium deposit in the Shangdan domain of the North Qinling Orogenic Belt, which is characterized by the enrichment of uraninite hosted in biotite granitic pegmatites. At Guangshigou, uraninite commonly occurs as mineral inclusions in quartz, K-feldspar and biotite or in interstices of these rock-forming minerals with magmatic characteristics (e.g., U/Th < 100, high ThO2, Y2O3 and REE2O3 contents and low concentrations of CaO, FeO and SiO2). It crystallized at 407.6 ± 2.9 Ma from fractionated calc-alkaline high-K pegmatitic melts under conditions of 470–700 °C and 2.4–3.4 kbar as deduced by the compositions of coexisting peritectic biotite. The primary uranium mineralization took place during the Late Caledonian post-collisional extension in the North Qinling Orogen. After this magmatic event, uraninite has experienced multiple episodes of fluid-assisted metasomatism, which generated an alteration halo of mineral assemblages. The alteration halo (or radiohalo) was the result of the combined effects of metamictization and metasomatism characterized by an assemblage of goethite, coffinite and an unidentified aluminosilicate (probably clay minerals) around altered uraninite. This fluid-assisted alteration was concomitant with the albitization of K-feldspar subsequently followed by the coffinitization of uraninite during the major period of 84.9–143.6 Ma, as determined by U-Th-Pb chemical ages. Further investigations revealed that the metasomatic overprinting on uraninite initially and preferentially took place along microcracks or cavities induced by metamictization and promoted their amorphization, followed by the release of U and Pb from structure and the incorporation of K, Ca and Si from the fluids, finally resulting in various degrees of uraninite coffinitization. The released U and Pb were transported by alkali-rich, relatively oxidizing fluids and then re-precipitated locally as coffinite and an amorphous U-Pb-rich silicate under low to moderate temperature conditions (85–174 °C). The compositional changes in primary uraninite, its structure amorphization together with the paragenetic sequence of secondary phases, therefore, corroborate a combined result of intense metamictization of uraninite and an influx of alkali–metasomatic fluids during the Late Mesozoic Yanshanian magmatic event in the region. Hence, the remobilization and circulation of uranium in the North Qinling Orogen was most likely driven by post-Caledonian magmatism and hydrothermal activities related to large-scale tectonic events. In this regards, Paleozoic pegmatite-type uranium mineralization may represent a significant uranium source for Mesozoic hydrothermal mineralization identified in the Qinling Orogenic Belt.
Salt Stress Mitigation via the Foliar Application of Chitosan-Functionalized Selenium and Anatase Titanium Dioxide Nanoparticles in Stevia (Stevia rebaudiana Bertoni)
Authors: Sheikhalipour Morteza , Esmaielpour Behrooz , Gohari Gholamreza , Haghighi Maryam , Jafari Hessam , Farhadi Habib , Kulak Muhittin , Kalisz Andrzej
Published: July 2021

High salt levels are one of the significant and major limiting factors on crop yield and productivity. Out of the available attempts made against high salt levels, engineered nanoparticles (NPs) have been widely employed and considered as effective strategies in this regard. Of these NPs, titanium dioxide nanoparticles (TiO2 NPs) and selenium functionalized using chitosan nanoparticles (Cs–Se NPs) were applied for a quite number of plants, but their potential roles for alleviating the adverse effects of salinity on stevia remains unclear. Stevia (Stevia rebaudiana Bertoni) is one of the reputed medicinal plants due to their diterpenoid steviol glycosides (stevioside and rebaudioside A). For this reason, the current study was designed to investigate the potential of TiO2 NPs (0, 100 and 200 mg L−1) and Cs–Se NPs (0, 10 and 20 mg L−1) to alleviate salt stress (0, 50 and 100 mM NaCl) in stevia. The findings of the study revealed that salinity decreased the growth and photosynthetic traits but resulted in substantial cell damage through increasing H2O2 and MDA content, as well as electrolyte leakage (EL). However, the application of TiO2 NPs (100 mg L−1) and Cs–Se NPs (20 mg L−1) increased the growth, photosynthetic performance and activity of antioxidant enzymes, and decreased the contents of H2O2, MDA and EL under the saline conditions. In addition to the enhanced growth and physiological performance of the plant, the essential oil content was also increased with the treatments of TiO2 (100 mg L−1) and Cs–Se NPs (20 mg L−1). In addition, the tested NPs treatments increased the concentration of stevioside (in the non-saline condition and under salinity stress) and rebaudioside A (under the salinity conditions) in stevia plants. Overall, the current findings suggest that especially 100 mg L−1 TiO2 NPs and 20 mg L−1 Cs–Se could be considered as promising agents in combating high levels of salinity in the case of stevia.
Effects of Graphene Nanoplatelets on Mechanical and Fire Performance of Flax Polypropylene Composites with Intumescent Flame Retardant
Authors: Ali Imran , Kim Nam Kyeun , Bhattacharyya Debes
Published: July 2021

The integration of intumescent flame-retardant (IFR) additives in natural fiber-based polymer composites enhances the fire-retardant properties, but it generally has a detrimental effect on the mechanical properties, such as tensile and flexural strengths. In this work, the feasibility of graphene as a reinforcement additive and as an effective synergist for IFR-based flax-polypropylene (PP) composites was investigated. Noticeable improvements in tensile and flexural properties were achieved with the addition of graphene nanoplatelets (GNP) in the composites. Furthermore, better char-forming ability of GNP in combination with IFR was observed, suppressing HRR curves and thus, lowering the total heat release (THR). Thermogravimetric analysis (TGA) detected a reduction in the decomposition rate due to strong interfacial bonding between GNP and PP, whereas the maximum decomposition rate was observed to occur at a higher temperature. The saturation point for the IFR additive along with GNP has also been highlighted in this study. A safe and effective method of graphene encapsulation within PP using the fume-hood set-up was achieved. Finally, the effect of flame retardant on the flax–PP composite has been simulated using Fire Dynamics Simulator.
Pharmacological Efficacy of Ginseng against Respiratory Tract Infections
Authors: Alsayari Abdulrhman , Muhsinah Abdullatif Bin , Almaghaslah Dalia , Annadurai Sivakumar , Wahab Shadma
Published: July 2021

Respiratory tract infections are underestimated, as they are mild and generally not incapacitating. In clinical medicine, however, these infections are considered a prevalent problem. By 2030, the third most comprehensive reason for death worldwide will be chronic obstructive pulmonary disease (COPD), according to the World Health Organization. The current arsenal of anti-inflammatory drugs shows little or no benefits against COPD. For thousands of years, herbal drugs have been used to cure numerous illnesses; they exhibit promising results and enhance physical performance. Ginseng is one such herbal medicine, known to alleviate pro-inflammatory chemokines and cytokines (IL-2, IL-4, IFN-γ, TNF-α, IL-5, IL-6, IL-8) formed by macrophages and epithelial cells. Furthermore, the mechanisms of action of ginsenoside are still not fully understood. Various clinical trials of ginseng have exhibited a reduction of repeated colds and the flu. In this review, ginseng’s structural features, the pathogenicity of microbial infections, and the immunomodulatory, antiviral, and anti-bacterial effects of ginseng were discussed. The focus was on the latest animal studies and human clinical trials that corroborate ginseng’s role as a therapy for treating respiratory tract infections. The article concluded with future directions and significant challenges. This review would be a valuable addition to the knowledge base for researchers in understanding the promising role of ginseng in treating respiratory tract infections. Further analysis needs to be re-focused on clinical trials to study ginseng’s efficacy and safety in treating pathogenic infections and in determining ginseng-drug interactions.
Additive Effects of Lithium Salts with Various Anionic Species in Poly (Methyl Methacrylate)
Authors: Ito Asae , Nitta Koh-hei
Published: July 2021

We report that lithium salts in lithium-ion batteries effectively modify the physical properties of poly (methyl methacrylate) (PMMA). The glass transition temperature (Tg) is an indicator of the heat resistance of amorphous polymers. The anionic species of the salts strongly affected the glass transition behavior of PMMA. We focused on the additive effects of various lithium salts, such as LiCF3SO3, LiCOOCF3, LiClO4, and LiBr, on the Tg of PMMA. The large anions of the former three salts caused them to form macroscopic aggregates that acted as fillers in the PMMA matrix and to combine the PMMA domains, increasing Tg. On the other hand, LiBr salts dispersed microscopically in the PMMA matrix at the molecular scale, leading to the linking of the PMMA chains. Thus, the addition of LiBr to PMMA increased Tg as well as the relaxation time in the range of glass to rubber transition.
Self-Assembled Bimetallic Aluminum-Salen Catalyst for the Cyclic Carbonates Synthesis
Authors: Seong Wooyong , Hahm Hyungwoo , Kim Seyong , Park Jongwoo , Abboud Khalil A. , Hong Sukwon
Published: July 2021

Bimetallic bis-urea functionalized salen-aluminum catalysts have been developed for cyclic carbonate synthesis from epoxides and CO2. The urea moiety provides a bimetallic scaffold through hydrogen bonding, which expedites the cyclic carbonate formation reaction under mild reaction conditions. The turnover frequency (TOF) of the bis-urea salen Al catalyst is three times higher than that of a μ-oxo-bridged catalyst, and 13 times higher than that of a monomeric salen aluminum catalyst. The bimetallic reaction pathway is suggested based on urea additive studies and kinetic studies. Additionally, the X-ray crystal structure of a bis-urea salen Ni complex supports the self-assembly of the bis-urea salen metal complex through hydrogen bonding.
Plants and Natural Products with Activity against Various Types of Coronaviruses: A Review with Focus on SARS-CoV-2
Authors: Llivisaca-Contreras Susana A. , Naranjo-Morán Jaime , Pino-Acosta Andrea , Pieters Luc , Vanden Berghe Wim , Manzano Patricia , Vargas-Pérez Jeffrey , León-Tamariz Fabian , Cevallos-Cevallos Juan M.
Published: July 2021

COVID-19 is a pandemic disease caused by the SARS-CoV-2 virus, which is potentially fatal for vulnerable individuals. Disease management represents a challenge for many countries, given the shortage of medicines and hospital resources. The objective of this work was to review the medicinal plants, foods and natural products showing scientific evidence for host protection against various types of coronaviruses, with a focus on SARS-CoV-2. Natural products that mitigate the symptoms caused by various coronaviruses are also presented. Particular attention was placed on natural products that stabilize the Renin–Angiotensin–Aldosterone System (RAAS), which has been associated with the entry of the SARS-CoV-2 into human cells.
Antioxidant, Anti-Inflammatory and Antithrombotic Effects of Ginsenoside Compound K Enriched Extract Derived from Ginseng Sprouts
Authors: Baik In-Hee , Kim Kyung-Hee , Lee Kyung-Ae
Published: July 2021

Partially purified ginsenoside extract (PGE) and compound K enriched extract (CKE) were prepared from ginseng sprouts, and their antioxidant, anti-inflammatory and antithrombotic effects were investigated. Compared to the 6-year-old ginseng roots, ginseng sprouts were found to have a higher content of phenolic compounds, saponin and protopanaxadiol-type ginsenoside by about 56%, 36% and 43%, respectively. PGE was prepared using a macroporous adsorption resin, and compound K(CK) was converted and enriched from the PGE by enzymatic hydrolysis with a conversion rate of 75%. PGE showed higher effects than CKE on radical scavenging activity in antioxidant assays. On the other hand, CKE reduced nitric oxide levels more effectively than PGE in RAW 264.7 cells. CKE also reduced pro-inflammatory cytokines, such as tumor necrosis factor-α, interleukin (IL)-1β and IL-6 than PGE. Tail bleeding time and volume were investigated after administration of CKE at 70–150 mg/kg/day to mice. CKE administered group showed a significant increase or increased tendency in bleeding time than the control group. Bleeding volume in the CKE group increased than the control group, but not as much as in the aspirin group. In conclusion, ginseng sprouts could be an efficient source of ginsenoside, and CKE converted from the ginsenosides showed antioxidant, anti-inflammatory and antithrombotic effects. However, it was estimated that the CKE might play an essential role in anti-inflammatory effects rather than antioxidant effects.
A Rapid Gas-Chromatography/Mass-Spectrometry Technique for Determining Odour Activity Values of Volatile Compounds in Plant Proteins: Soy, and Allergen-Free Pea and Brown Rice Protein
Authors: Singh Anika , Shi Yuan , Magreault Perrine , Kitts David D. , Jarzębski Maciej , Siejak Przemysław , Pratap-Singh Anubhav
Published: July 2021

Plant-based protein sources have a characteristic aroma that limits their usage in various meat-alternative formulations. Despite being the most popular plant-based protein, the allergenicity of soy protein severely restricts the potential adoption of soy protein as an animal substitute. Thereby, allergen-free plant-protein sources need to be characterized. Herein, we demonstrate a rapid solid-phase-microextraction gas-chromatography/mass-spectrometry (SPME-GC/MS) technique for comparing the volatile aroma profile concentration of two different allergen-free plant-protein sources (brown rice and pea) and comparing them with soy protein. The extraction procedure consisted of making a 1:7 w/v aqueous plant protein slurry, and then absorbing the volatile compounds on an SPME fibre under agitation for 10 min at 40 °C, which was subsequently injected onto a GC column coupled to an MS system. Observed volatile concentrations were used in conjunction with odour threshold values to generate a Total Volatile Aroma Score for each protein sample. A total of 76 volatile compounds were identified. Aldehydes and furans were determined to be the most dominant volatiles present in the plant proteins. Both brown rice protein and pea protein contained 64% aldehydes and 18% furans, with minor contents of alcohols, ketones and other compounds. On the other hand, soy protein consisted of fewer aldehydes (46%), but a more significant proportion of furans (42%). However, in terms of total concentration, brown rice protein contained the highest intensity and number of volatile compounds. Based on the calculated odour activity values of the detected compounds, our study concludes that pea proteins could be used as a suitable alternative to soy proteins in applications for allergen-free vegan protein products without interfering with the taste or flavour of the product.
Anomalous Lehmann Rotation of Achiral Nematic Liquid Crystal Droplets Trapped under Linearly Polarized Optical Tweezers
Authors: Kiang-ia Jarinee , Taeudomkul Rahut , Prajongtat Pongthep , Tin Padetha , Pattanaporkratana Apichart , Chattham Nattaporn
Published: July 2021

Continuous rotation of a cholesteric droplet under the heat gradient was observed by Lehmann in 1900. This phenomenon, the so-called Lehmann effect, consists of unidirectional rotation around the heat flux axis. We investigate this gradient heat effect using infrared laser optical tweezers. By applying single trap linearly polarized optical tweezers onto a radial achiral nematic liquid crystal droplet, trapping of the droplet was performed. However, under a linearly polarized optical trap, instead of stable trapping of the droplet with slightly deformed molecular directors along with a radial hedgehog defect, anomalous continuous rotation of the droplet was observed. Under low power laser trapping, the droplet appeared to rotate clockwise. By continuously increasing the laser power, a stable trap was observed, followed by reverse directional rotation in a higher intensity laser trap. Optical levitation of the droplet in the laser beam caused the heat gradient, and a breaking of the symmetry of the achiral nematic droplet. These two effects together led to the rotation of the droplet under linearly polarized laser trapping, with the sense of rotation depending on laser power.
Pauling’s Conceptions of Hybridization and Resonance in Modern Quantum Chemistry
Authors: Glendening Eric D. , Weinhold Frank
Published: July 2021

We employ the tools of natural bond orbital (NBO) and natural resonance theory (NRT) analysis to demonstrate the robustness, consistency, and accuracy with which Linus Pauling’s qualitative conceptions of directional hybridization and resonance delocalization are manifested in all known variants of modern computational quantum chemistry methodology.
Optimization of Sample Preparation for Metabolomics Exploration of Urine, Feces, Blood and Saliva in Humans Using Combined NMR and UHPLC-HRMS Platforms
Authors: Martias Cécile , Baroukh Nadine , Mavel Sylvie , Blasco Hélène , Lefèvre Antoine , Roch Léa , Montigny Frédéric , Gatien Julie , Schibler Laurent , Dufour-Rainfray Diane , Nadal-Desbarats Lydie , Emond Patrick
Published: July 2021

Currently, most clinical studies in metabolomics only consider a single type of sample such as urine, plasma, or feces and use a single analytical platform, either NMR or MS. Although some studies have already investigated metabolomics data from multiple fluids, the information is limited to a unique analytical platform. On the other hand, clinical studies investigating the human metabolome that combine multi-analytical platforms have focused on a single biofluid. Combining data from multiple sample types for one patient using a multimodal analytical approach (NMR and MS) should extend the metabolome coverage. Pre-analytical and analytical phases are time consuming. These steps need to be improved in order to move into clinical studies that deal with a large number of patient samples. Our study describes a standard operating procedure for biological specimens (urine, blood, saliva, and feces) using multiple platforms (1H-NMR, RP-UHPLC-MS, and HILIC-UHPLC-MS). Each sample type follows a unique sample preparation procedure for analysis on a multi-platform basis. Our method was evaluated for its robustness and was able to generate a representative metabolic map.
4-Phenethyl-1-Propargylpiperidine-Derived Dual Inhibitors of Butyrylcholinesterase and Monoamine Oxidase B
Authors: Mazej Tjaša , Knez Damijan , Meden Anže , Gobec Stanislav , Sova Matej
Published: July 2021

The multi-target-directed ligands (MTDLs) strategy is encouraged for the development of novel modulators targeting multiple pathways in the neurodegenerative cascade typical for Alzheimer’s disease (AD). Based on the structure of an in-house irreversible monoamine oxidase B (MAO-B) inhibitor, we aimed to introduce a carbamate moiety on the aromatic ring to impart cholinesterase (ChE) inhibition, and to furnish multifunctional ligands targeting two enzymes that are intricately involved in AD pathobiology. In this study, we synthesized three dual hMAO-B/hBChE inhibitors 13–15, with compound 15 exhibiting balanced, low micromolar inhibition of hMAO-B (IC50 of 4.3 µM) and hBChE (IC50 of 8.5 µM). The docking studies and time-dependent inhibition of hBChE confirmed the initial expectation that the introduced carbamate moiety is responsible for covalent inhibition. Therefore, dual-acting compound 15 represents an excellent starting point for further optimization of balanced MTDLs
Impact of Fluoroalkylation on the n-Type Charge Transport of Two Naphthodithiophene Diimide Derivatives
Authors: Ricci Gaetano , Canola Sofia , Dai Yasi , Fazzi Daniele , Negri Fabrizia
Published: July 2021

In this work, we investigate two recently synthesized naphthodithiophene diimide (NDTI) derivatives featuring promising n-type charge transport properties. We analyze the charge transport pathways and model charge mobility with the non-adiabatic hopping mechanism using the Marcus-Levich-Jortner rate constant formulation, highlighting the role of fluoroalkylated substitution in α (α-NDTI) and at the imide nitrogen (N-NDTI) position. In contrast with the experimental results, similar charge mobilities are computed for the two derivatives. However, while α-NDTI displays remarkably anisotropic mobilities with an almost one-dimensional directionality, N-NDTI sustains a more isotropic charge percolation pattern. We propose that the strong anisotropic charge transport character of α-NDTI is responsible for the modest measured charge mobility. In addition, when the role of thermally induced transfer integral fluctuations is investigated, the computed electron–phonon couplings for intermolecular sliding modes indicate that dynamic disorder effects are also more detrimental for the charge transport of α-NDTI than N-NDTI. The lower observed mobility of α-NDTI is therefore rationalized in terms of a prominent anisotropic character of the charge percolation pathways, with the additional contribution of dynamic disorder effects.
In Search of an Efficient Complexing Agent for Oxalates and Phosphates: A Quantum Chemical Study
Authors: Vekeman Jelle , Torres Javier , David Cristina Eugenia , Van de Perre Els , Wissing Karl Martin , Letavernier Emmanuel , Bazin Dominique , Daudon Michel , Pozdzik Agnieszka , Tielens Frederik
Published: July 2021

Limiting gastrointestinal oxalate absorption is a promising approach to reduce urinary oxalate excretion in patients with idiopathic and enteric hyperoxaluria. Phosphate binders, that inhibit gastrointestinal absorption of dietary phosphate by the formation of easily excretable insoluble complexes, are commonly used as a treatment for hyperphosphatemia in patients with end-stage renal disease. Several of these commercially available phosphate binders also have affinity for oxalate. In this work, a series of metallic cations (Li+, Na+, Mg2+, Ca2+, Fe2+, Cu2+, Zn2+, Al3+, Fe3+ and La3+) is investigated on their binding affinity to phosphate and oxalate on one side and anionic species that could be used to administer the cationic species to the body on the other, e.g., acetate, carbonate, chloride, citrate, formate, hydroxide and sulphate. Through quantum chemical calculations, the aim is to understand the competition between the different complexes and propose possible new and more efficient phosphate and oxalate binders.
The First Record of Echinococcus ortleppi (G5) Tapeworms in Grey Wolf (Canis lupus)
Authors: Karamon Jacek , Samorek-Pieróg Małgorzata , Sroka Jacek , Bilska-Zając Ewa , Dąbrowska Joanna , Kochanowski Maciej , Różycki Mirosław , Zdybel Jolanta , Cencek Tomasz
Published: July 2021

The aim of this study is to confirm the presence and molecular identification of Echinococcus tapeworms in wolves from south-eastern Poland. An investigation was carried out on the intestines of 13 wolves from south-eastern Poland. The small intestines were divided into three equal segments. Each segment was separately examined using the sedimentation and counting technique (SCT). The detected Echinococcus tapeworms were isolated and identified by PCRs and sequencing (nad1 and cox1 genes). Additionally, DNA isolated from the feces of wolves positive for Echinococcus tapeworms was examined with two diagnostic PCRs. The intestines of one wolf were positive for E. granulosus s.l. when assessed by SCT; the intestine was from a six-year-old male wolf killed in a communication accident. We detected 61 adult tapeworms: 42 in the anterior, 14 in the middle, and 5 in the posterior parts of the small intestine. The PCRs conducted for cox1 and nad1 produced specific products. A sequence comparison with the GenBank database showed similarity to the deposited E. ortleppi (G5) sequences. An analysis of the available phylogenetic sequences showed very little variation within the species of E. ortleppi (G5), and identity ranged from 99.10% to 100.00% in the case of cox1 and from 99.04% to 100.00% in the case of nad1. One of the two diagnostic PCRs used and performed on the feces of Echinococcus-positive animals showed product specific for E. granulosus. This study showed the presence of adult E. ortleppi tapeworms in wolves for the first time.
Nondegenerate Bright Solitons in Coupled Nonlinear Schrödinger Systems: Recent Developments on Optical Vector Solitons
Authors: Stalin S. , Ramakrishnan R. , Lakshmanan M.
Published: July 2021

Nonlinear dynamics of an optical pulse or a beam continue to be one of the active areas of research in the field of optical solitons. Especially, in multi-mode fibers or fiber arrays and photorefractive materials, the vector solitons display rich nonlinear phenomena. Due to their fascinating and intriguing novel properties, the theory of optical vector solitons has been developed considerably both from theoretical and experimental points of view leading to soliton-based promising potential applications. Mathematically, the dynamics of vector solitons can be understood from the framework of the coupled nonlinear Schrödinger (CNLS) family of equations. In the recent past, many types of vector solitons have been identified both in the integrable and non-integrable CNLS framework. In this article, we review some of the recent progress in understanding the dynamics of the so called nondegenerate vector bright solitons in nonlinear optics, where the fundamental soliton can have more than one propagation constant. We address this theme by considering the integrable two coupled nonlinear Schrödinger family of equations, namely the Manakov system, mixed 2-CNLS system (or focusing-defocusing CNLS system), coherently coupled nonlinear Schrödinger (CCNLS) system, generalized coupled nonlinear Schrödinger (GCNLS) system and two-component long-wave short-wave resonance interaction (LSRI) system. In these models, we discuss the existence of nondegenerate vector solitons and their associated novel multi-hump geometrical profile nature by deriving their analytical forms through the Hirota bilinear method. Then we reveal the novel collision properties of the nondegenerate solitons in the Manakov system as an example. The asymptotic analysis shows that the nondegenerate solitons, in general, undergo three types of elastic collisions without any energy redistribution among the modes. Furthermore, we show that the energy sharing collision exhibiting vector solitons arises as a special case of the newly reported nondegenerate vector solitons. Finally, we point out the possible further developments in this subject and potential applications.
Determination of Phenolic Content, Antioxidant Activity, and Tyrosinase Inhibitory Effects of Functional Cosmetic Creams Available on the Thailand Market
Authors: Mapoung Sariya , Semmarath Warathit , Arjsri Punnida , Umsumarng Sonthaya , Srisawad Kamonwan , Thippraphan Pilaiporn , Yodkeeree Supachai , Limtrakul (Dejkriengkraikul) Pornngarm
Published: July 2021

Recently, the global trend toward the use of natural extracts and antioxidant agents in the cosmetic cream industry to produce whitening effects has been increasing. This has also been a persistent trend in Thailand. In this study, samples of commercial cosmetic creams on the Thai market were assessed for a functional evaluation of their antioxidant activity, tyrosinase inhibitory effects, and phenolic contents. Samples were extracted using hot water and sonication extraction method to obtain the functional cream extracts. Total phenolic contents in all samples were within the range of 0.46–47.92 mg GAE/30 g cream. Antioxidant activities of the cream extracts were within the range of 3.61–43.98 mg Trolox equivalent/30 g cream, while tyrosinase inhibition activities were within the range of 2.58–97.94% of inhibition. With regard to the relationship between the total phenolic content and the antioxidant activity of the cosmetic creams, Pearson’s correlation coefficient revealed a moderately positive relationship with an r value of 0.6108. Furthermore, the relationship between the antioxidant activity and the tyrosinase inhibitory activity of the cosmetic creams was highly positive with an r value of 0.7238. Overall, this study demonstrated that the total phenolic contents in the functional cosmetic creams could play a role in antioxidant activity and anti-tyrosinase activities. The findings indicate how the whitening and antioxidant effects of cosmetic creams could be maintained after the products have been formulated, as this concern can affect the consumer’s decision when purchasing cosmetic products.
Study on the Unbalanced Curl Seal Failure of the Magnetorheological Fluid Sealing Device of the Hydraulic Turbine Main Shaft under Different Speed Abrupt Conditions
Authors: Cheng Jie , Li Zheng-Gui , Xu Yang , Li Wang-Xu , Li Xin-Rui
Published: July 2021

The fluid flow in the runner of a hydraulic turbine has serious uncertainties. The sealing failure of the magnetorheological (MR) fluid sealing device of the main shaft of the hydroturbine, caused by a sudden change in speed, has always been a difficult topic to research. This study first derives the MR fluid seal pressure and unbalanced curl equations of the hydroturbine main shaft, and then analyzes the seal pressure and friction heat under different rotational speed mutation conditions through experiments. After verification, the temperature field and magnetic field distribution of the MR fluid sealing device of the main shaft of the hydraulic turbine are obtained via numerical calculation. The results show that the external magnetic field affects the magnetic moment of the magnetic particles in the MR fluid, resulting in a significant change in frictional heat, thereby reducing the saturation of magnetic induction intensity of the MR fluid. This results in a decrease in the sealing ability of the device. The size and abrupt amplitude of the main shaft of the hydraulic turbine, and friction heat is positively correlated reducing the sealing ability of the device and causing sealing failure. Based on our results, we recommend adding the necessary cooling to the device to reduce the frictional heat, thereby increasing the seal life of the device.
An In-Depth Process Model for Fuel Production via Hydrothermal Liquefaction and Catalytic Hydrotreating
Authors: Moser Leonard , Penke Christina , Batteiger Valentin
Published: July 2021

One of the more promising technologies for future renewable fuel production from biomass is hydrothermal liquefaction (HTL). Although enormous progress in the context of continuous experiments on demonstration plants has been made in the last years, still many research questions concerning the understanding of the HTL reaction network remain unanswered. In this study, a unique process model of an HTL process chain has been developed in Aspen Plus® for three feedstock, microalgae, sewage sludge and wheat straw. A process chain consisting of HTL, hydrotreatment (HT) and catalytic hydrothermal gasification (cHTG) build the core process steps of the model, which uses 51 model compounds representing the hydrolysis products of the different biochemical groups lipids, proteins, carbohydrates, lignin, extractives and ash for modeling the biomass. Two extensive reaction networks of 272 and 290 reactions for the HTL and HT process step, respectively, lead to the intermediate biocrude (~200 model compounds) and the final upgraded biocrude product (~130 model compounds). The model can reproduce important characteristics, such as yields, elemental analyses, boiling point distribution, product fractions, density and higher heating values of experimental results from continuous experiments as well as literature values. The model can be applied as basis for techno-economic and environmental assessments of HTL fuel production, and may be further developed into a predictive yield modeling tool.
Bridgeless Isolated AC LED Driver
Authors: Yau Yeu-Torng , Hwu Kuo-Ing , Wang Chao-Wei
Published: July 2021

A novel bridgeless isolated AC LED driver is developed, which improves LED utilization and application flexibility due to a coupled inductor inserted between the bidirectional switch and the LED module without any output electrolytic capacitor. By reducing the turns ratio of the coupled inductor, the voltage across the secondary side will be decreased so as to lessen the voltage across the LED strings and hence reduce the number of LEDs, thereby making the load design of the AC LED driver more flexible. It is noted that the coupled inductor plays a role of not only galvanic isolation but also inductor behavior as well as transformer behavior. Therefore, during the turn-on period of the bidirectional switch, the coupled inductor can transfer the energy to one LED string and store the energy simultaneously, whereas during the turn-off period of the bidirectional switch, the coupled inductor can release the stored energy to the other LED string. That is, two LED strings are conducted over a pulse-width-modulated (PWM) period for any half-cycle, implying that LED utilization is upgraded. As for LED dimming, it is realized by directly tuning the control signal for the bidirectional switch without any dimming circuit. Eventually, the basic operating principles and theoretical deductions are given along with some experimental results provided to verify the effectiveness of the proposed AC LED driver topology.
Nano-Adsorbents for Cobalt Removal from Wastewater: A Bibliometric Analysis of Research Articles Indexed in the Scopus Database
Authors: Prochaska Charikleia , Gallios George
Published: July 2021

In this study, a combined technique of bibliometric and social network analysis was applied on research articles, related to the application of nano-adsorbents for cobalt removal from wastewater, published in Scopus database up to 2020. The results revealed that the first relative research article appeared in the Scopus database in the year 2002. The total output of research articles reached 214 in the year 2020. Published research articles of the years 2014–2020, added up to 83.6% of total articles. King Saud University of Saudi Arabia, Chinese Academy of Science, and LUT University of Finland were found to serve as the gatekeepers who control information flows in the network of the most prolific institutions, while cooperation between China, Saudi Arabia, and United States was also identified. On average, the most prolific authors cooperated with five others, while the top 10 cited publications appeared to represent a sparse and weakly interconnected network of co-authors. Graphene oxide was the most prominent nano-adsorbent among the top 10 cited publications, and their respective co-citations network visualization helped in capturing the value of certain citations to the evolution of the research on the topic, putting thus scientific work impact assessment to a different perspective.
Classification Method of Uniform Circular Array Radar Ground Clutter Data Based on Chaotic Genetic Algorithm
Authors: Yang Bin , Huang Mo , Xie Yao , Wang Changyuan , Rong Yingjiao , Huang Huihui , Duan Tao
Published: July 2021

The classification and recognition of radar clutter is helpful to improve the efficiency of radar signal processing and target detection. In order to realize the effective classification of uniform circular array (UCA) radar clutter data, a classification method of ground clutter data based on the chaotic genetic algorithm is proposed. In this paper, the characteristics of UCA radar ground clutter data are studied, and then the statistical characteristic factors of correlation, non-stationery and range-Doppler maps are extracted, which can be used to classify ground clutter data. Based on the clustering analysis, results of characteristic factors of radar clutter data under different wave-controlled modes in multiple scenarios, we can see: in radar clutter clustering of different scenes, the chaotic genetic algorithm can save 34.61% of clustering time and improve the classification accuracy by 42.82% compared with the standard genetic algorithm. In radar clutter clustering of different wave-controlled modes, the timeliness and accuracy of the chaotic genetic algorithm are improved by 42.69% and 20.79%, respectively, compared to standard genetic algorithm clustering. The clustering experiment results show that the chaotic genetic algorithm can effectively classify UCA radar’s ground clutter data.
Stream-Based Visually Lossless Data Compression Applying Variable Bit-Length ADPCM Encoding
Authors: Yamagiwa Shinichi , Ichinomiya Yuma
Published: July 2021

Video applications have become one of the major services in the engineering field, which are implemented by server–client systems connected via the Internet, broadcasting services for mobile devices such as smartphones and surveillance cameras for security. Recently, the majority of video encoding mechanisms to reduce the data rate are mainly lossy compression methods such as the MPEG format. However, when we consider special needs for high-speed communication such as display applications and object detection ones with high accuracy from the video stream, we need to address the encoding mechanism without any loss of pixel information, called visually lossless compression. This paper focuses on the Adaptive Differential Pulse Code Modulation (ADPCM) that encodes a data stream into a constant bit length per data element. However, the conventional ADPCM does not have any mechanism to control dynamically the encoding bit length. We propose a novel ADPCM that provides a mechanism with a variable bit-length control, called ADPCM-VBL, for the encoding/decoding mechanism. Furthermore, since we expect that the encoded data from ADPCM maintains low entropy, we expect to reduce the amount of data by applying a lossless data compression. Applying ADPCM-VBL and a lossless data compression, this paper proposes a video transfer system that controls throughput autonomously in the communication data path. Through evaluations focusing on the aspects of the encoding performance and the image quality, we confirm that the proposed mechanisms effectively work on the applications that needs visually lossless compression by encoding video stream in low latency.
Virtual Sensoring of Motion Using Pontryagin’s Treatment of Hamiltonian Systems
Authors: Sands Timothy
Published: July 2021

To aid the development of future unmanned naval vessels, this manuscript investigates algorithm options for combining physical (noisy) sensors and computational models to provide additional information about system states, inputs, and parameters emphasizing deterministic options rather than stochastic ones. The computational model is formulated using Pontryagin’s treatment of Hamiltonian systems resulting in optimal and near-optimal results dependent upon the algorithm option chosen. Feedback is proposed to re-initialize the initial values of a reformulated two-point boundary value problem rather than using state feedback to form errors that are corrected by tuned estimators. Four algorithm options are proposed with two optional branches, and all of these are compared to three manifestations of classical estimation methods including linear-quadratic optimal. Over ten-thousand simulations were run to evaluate each proposed method’s vulnerability to variations in plant parameters amidst typically noisy state and rate sensors. The proposed methods achieved 69–72% improved state estimation, 29–33% improved rate improvement, while simultaneously achieving mathematically minimal costs of utilization in guidance, navigation, and control decision criteria. The next stage of research is indicated throughout the manuscript: investigation of the proposed methods’ efficacy amidst unknown wave disturbances.