bluuebunny/crossref_metadata_2025 huggingface dataset:
Leucemia mieloide crônica: aspectos fisiopatológicos, diagnóstico e tratamento
Authors: Ferreira Juliana Renata da Silva , Silva Danyele Karla de Souza , Silva Gabriel Ferreira da , Ferreira Júlia Roberta da Silva
Published: June 2024

A Leucemia Mielóide Crônica (LMC) é uma doença mieloproliferativa clonal das células pluripotentes da medula óssea, acomete predominantemente adultos entre 40 e 60 anos. É um tipo de câncer não hereditário que se desenvolve na medula óssea e é caracterizada pela presença do Cromossomo Philadelphia (Ph), que resulta da translocação recíproca e equilibrada entre os braços longos dos cromossomos 9q34 e 22q11, gerando a proteína híbrida BCR-ABL, que está relacionada com a patogênese da doença1 . Assim sendo, para confirmação diagnóstica e monitoração do tratamento, são utilizadas as análises citogenéticas e moleculares2 . O objetivo deste trabalho é dissertar sobre a fisiopatologia da LMC, a partir de uma revisão da literatura sobre o tema, visando seus aspectos diagnósticos e tratamento. Foi realizada uma revisão da literatura a partir da busca de artigos na base de dados Medical Literature Analysis and Retrieval System Online (MEDLINE/PubMed) com o uso dos descritores “Chronic Myeloid Leukemia”, “Ph Chromosome”, “Translocation”, “BCR/ABL”, “Treatment”, “Diagnosis”; além do uso do operador booleano “AND”. Dentre as bibliografias adequadas para o objetivo, foram selecionados artigos que serviram de referência e base para este estudo. A LMC é definida a partir de uma translocação recíproca entre os cromossomos 9 e 22 (transferência do oncogene ABL do locus 9q11 e BCR em 22q11 que origina o gene híbrido BCR- ABL) formando o Ph1 . Essa fusão resulta em uma expressão da proteína p210, uma proteína de fusão com atividade tirosina quinase exacerbada e que está alusiva com a patogênese da doença3 . Tal remodelação acarretará em uma proliferação clonal de células progenitoras hematopoéticas 36 pluripotentes, com consequente estímulo autônomo da hematopoese, tornando propício à expansão de células de linhagem mielóide4 . Isto posto, ocorre uma liberação antecipada das células mielóides imaturas para o sangue periférico. O curso clínico da doença é dividido em três fases: uma fase crônica; uma fase acelerada e, por fim, uma fase blástica1 . Entre os principais exames diagnósticos, tem-se o hemograma, apresentando hiperleucocitose, aparecimento de células imaturas e aumento de eosinófilos e basófilos; outros exames como análises citogenéticas e moleculares também são essenciais para o diagnóstico da LMC5 . Em relação às opções terapêuticas, a descoberta da associação do oncogene BCR-ABL com a patogênese da doença permitiu o desenvolvimento de medicamentos com alvos moleculares específicos, os chamados inibidores de tirosina quinase, além da possibilidade de realização do transplante de medula óssea2,5. Em suma, é importante o conhecimento das repercussões da doença, para que, dessa forma, o diagnóstico possa ser realizado de uma maneira mais assertiva e, consequentemente, o curso do tratamento possa trazer maiores benefícios ao paciente.
Regulação transcricional mediada por NPM1 da via de sinalização β-catenina observada em rede de interação proteína-proteína na leucemia mieloide aguda
Authors: Ribeiro Lucas Nascimento , Freitas Antonio Carlos de , Neto Pedro Luiz de França , Salvi Marisa , Santos Vanessa Emanuelle Pereira
Published: June 2024

A cascata de sinalização da viaWnt/ β-catenina é bem conhecida pela manutenção da homeostase em diversos sistemas corporais. Nas últimas décadas, uma robusta literatura vem sendo construída sobre as influências intra e extracelulares da desregulação dessa via em neoplasias como a Leucemia Mieloide Aguda (LMA)3 . Uma vez que as estratégias quimioterápicas estão alcançando seu limite terapêutico, vem se tornando interessante a investigação de novos alvos moleculares2 . Há 10 anos, já é de conhecimento da comunidade científica que a nucleofosmina (NPM1) é um dos genes mais alterados em pacientes com cariótipo normal, com altas taxas de ocorrência em adultos1 . Porém, sua interação com a via Wnt/β- catenina e essa importância na LMA necessita de maiores elucidações. Portanto, o objetivo do presente trabalho foi predizer uma rede de interação de NPM1 com a via Wnt/β- cateninana LMA. A rede de interação foi predita no banco de dados público String, na aba Pathway/Process/Disease com os descritores “acutemyeloidleucemia-DOID:9119”, para o organismo Homo Sapiens. Os dados foram minerados utilizando o threeshold hight confidence 0,7 e utilizando todas as fontes de interações disponíveis. A rede de interação construída apresentou um valor de enriquecimento de p- value<10-16 e interações entre 33 proteínas, dentre as quais, NPM1 e CTNNB1, que interagem de forma indireta. A partir dos resultados da rede PPI, 100 sugere-se que NPM1 interage com os fatores de transcrição STAT5B, RUNX1 e CBFA2T3, culminando na interação com o dedo de zinco GLIS2, que tem por efeito diminuir a transcrição mediada pela via β-catenina. O NPM1 constitui um marcador de bom prognóstico para LMA1 e a atividade transcricional de β-catenina é aberrante e desregulada no núcleo celular de linhagens celulares de LMA3 . Pelo fato de, até o momento, não ter sido padronizado nenhum inibidor eficaz de β-catenina, no núcleo celular3 , a regulação negativa por NPM1 pode ser uma via candidata. A partir dos achados do presente trabalho, é sugestivo que há uma repressão transcricional indireta de β-catenina a partir da interação do NPM1 com os fatores de transcrição adjacentes: STAT5B, RUNX1, CBFA2T3 e GLIS2. A partir disso, sugere-se que a regulação negativa da β-catenina por parte de NPM1 pode ser um dos motivos de sua associação com o bom prognóstico de pacientes com LMA. Por fim, para confirmar esse fato, estudos experimentais são necessários para avaliar a correlação entre esse gene e a inibição da atividade de β-catenina.
O Estágio Supervisionado como Pesquisa em Educação e Ciências na Amazônia: Diálogos e Experiências de Intervenção Pedagógica
Authors: Albuquerque Jacirene Vasconcelos de , Leal José Fernando Pereira , Silva Luely Oliveira da , Souza Ronilson Freitas de
Published: June 2024

O Documento Orientador da Área de Ensino da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) prevê que no curso de mestrado profissional deve haver “prática profissional docente como requisito obrigatório para a integralização curricular”. Nesse sentido, no Programa de Pós-graduação em Educação e Ensino de Ciências na Amazônia (PPGEECA), da Universidade do Estado do Pará (UEPA), esta prática é entendida como Estágio Supervisionado, compreendido em sua estrutura curricular em duas disciplinas. No PPGEECA/UEPA, o estágio se configura como um espaço de formação, ao possibilitar a pesquisa sobre a sala de aula, a escola e os ambientes não escolares, visando problematizar para compreender as situações observadas durante sua realização e a partir delas propor e desenvolver Produtos e Processos Educacionais (PE). Os/as mestrandos/as, ao consolidarem posturas e habilidades de pesquisadores/as no campo da formação de professores/as e ensino de Ciências em contextos amazônicos, ressignificam as práticas de ensino e aprendizagem na educação básica. Socializar as práticas de estágio desenvolvidas no Programa, contribuirá para a divulgação das experiências consolidadas no PPGEECA/UEPA.
Development of Illustrated Storybooks as a Learning Medium to Enhance Students' Reading Interest
Authors: Latifa Gusti , Suzanne Nina , Zulhendri Zulhendri
Published: June 2024

An important component of elementary school students' academic growth is their enthusiasm for reading, especially in the lower grades. The purpose of this study is to examine students' demands for illustrated storybooks, confirm the accuracy of the created books, gauge how useful they are for piqueing children's interest in reading, and measure the effects of utilizing these books in the classroom. This study uses a research and development methodology to gather both quantitative and qualitative data. The four steps of the research process define, design, develop, and disseminate are guided by the 4D model. The results of this study support the usefulness of employing illustrated storybooks to increase pupils' enthusiasm for reading. The storybooks are suitable to satisfy the demands of the pupils thanks to the creation and validation procedures. The storybooks' ability to encourage reading engagement among primary school pupils is shown by the favorable response from instructors and students regarding the usefulness of the books. This study makes a contribution to the field of education by offering instructors insightful information and a useful tool to raise their students' motivation for reading and general literacy ability.
The Effect of Realistic Mathematics Education (RME) Learning Approach on the Ability to Recognize Number Concepts in Children Aged 4-5 Years
Authors: Sari Indah Puspita , Warmansyah Jhoni , Yuningsih Restu , Sari Meliana , Yandira Rahayu
Published: June 2024

This research aims to determine the effect of a realistic mathematics learning approach (PMR) on the ability to recognize the concept of numbers. This research is a quantitative research with pre-experimental design. This research was conducted at Pertiwi Batusangkar Kindergarten, Tanah Datar District. The data collection technique in this study is total sampling. In general, the results of this study indicate that the open-ended learning approach has a significant effect, that t0 is greater than the tt value table (14.01> 2.9980), so the null hypothesis (h0) proposed is rejected and the alternative hypothesis (ha) accepted to develop the ability to recognize children's number concepts at the age of 4-5 years. Thus the realistic mathematics education learning approach (PMR) has an effect on the introduction of the concept of numbers in early childhood.
The Role of Human Resources in Islamic Education in the Era of Civil Society 5.0
Authors: Syamsi Badrus , Zamroni Zamroni
Published: June 2024

The increased role of technology and the complexity of societal changes have ushered in a new era in education, known as Civil Society 5.0. This research aims to explore the role of Human Resources at MTs Darussalam Samarinda in adapting to the Civil Society 5.0 era. The research methodology employed a qualitative-descriptive approach, utilizing interview data from all available human resources within the madrasah. Observations were conducted in the field to validate the obtained data, both from interview transcripts and documents. Data analysis involved an interactive technique encompassing collection, condensation, presentation, and conclusion drawing. The research findings emphasize the pivotal role of Human Resources in adopting technology for learning, adjusting the curriculum to meet contemporary demands, and establishing robust collaborations within the local community. Islamic education Human Resources are not merely instructors; they also serve as change leaders, shaping students' characters, upholding religious values, and preparing students to actively engage in a dynamic society.
Implementation of the Tahsin Method in Improving Quality Fashohah Students Studying Qur'an Hadith at Madrasah Ibtidaiyah
Authors: Nadlir Nadlir , Negari Beauty Dewi , Ta'dzimah Imamatut , Ummah Durroh Nasihatul
Published: June 2024

While learning Al-Quran Hadith, some students often encounter several obstacles,one of which is the aspect of reading the Al-Quran. Not a few of them are still notfluent when reading the Al-Quran and have not applied it fashohah appropriate,as well as the application of makharijul letters and tajwid. The purpose of writingthis research is to see the level of success of the tahsin method in improving andimproving students' reading of the Al-Quran so that students can read the Al-Qurancorrectly according to the pronunciation of the hijaiyah letters and the correctrules for reciting tajwid. This research uses the method of Systematic LiteratureReview (SLR) which means reviewing the results of previous research regardingthe application of the tahsin method to improve quality fashohah. The results ofthis research show that the tahsin method can improve the quality of fashohahstudents, one of which is in the application of Al-Quran Hadith learning. This isbecause the tahsin method is suitable for various groups, especially children, forwhom at the elementary school or madrasah ibtidaiyah level it is the foundationfor further learning.
The Implementation Learning Media Based on a Culture to Develop Student Character
Authors: Sari Dwhy Dinda , Ilham Muhammad , Fuadi Noval , Nurviani Rahima
Published: June 2024

The research aims to find out how culture-based learning media to develop student character at Srikandi Kindergarten in Lhokseumawe City and what obstacles teachers find in the implementation in the classroom. This research uses a descriptive qualitative research approach. The subjects in the study were students at Srikandi Kindergarten Lhokseumawe City, class teachers and principals. Data analysis techniques in this study include data collection, data reduction, data presentation and conclusion drawing. The results of this study found that culture-based learning media significantly contribute to students' character development by encouraging a deeper awareness and appreciation of diverse cultural perspectives, beliefs and practices, culture-based learning media foster empathy and understanding of others by exposing children to the traditions, practices and ways of life of other cultures. Kindergarten children learn to recognize and respect human differences and similarities through stories, music and visual representations of different cultures. The barriers found were the students' different knowledge and viewpoints regarding culture.
Optimization of Early Childhood Social Emotional Development Through Exercise Methods and Learning Videos
Authors: Salum Raisa Nur , Khadijah Khadijah , Liza Nasution Nurul
Published: June 2024

This research aims to investigate ways to enhance the social and emotional development of young children through Drill and video learning methods. The research topic covers the definition and importance of social-emotional development in young children, learning through Drill and video methods in young children, and strategies to enhance social-emotional development through Drill and video methods in young children. The method used in this research is qualitative with a literature study, using data sources such as journals and books published in the last 5 years. The results show that, first, social-emotional development in young children refers to the process by which children develop the ability to interact socially and manage their emotions effectively. This involves understanding and expressing emotions, developing social relationships, and adapting to their social environment. Second, learning through Drill and video methods is an effective way to encourage active participation, cooperation, and the development of social-emotional skills in young children. Through Drill and video learning methods, children can learn to interact, share, and collaborate while also developing cognitive and academic skills. Third, strategies to optimize the social-emotional development of young children through Drill and video learning methods include forming inclusive groups, facilitating positive interactions, developing social skills, cooperative games, facilitating emotional expression, positive feedback, and leadership concept building.
The Role of Shadow Teachers For Supporting Learning Assistance on Children with Special Needs in Inclusive Early Childhood Education
Authors: Nisa Uswatun , Zain Anwar , Rahmah Aulia
Published: June 2024

Inclusive education is an implementation of the international consensus of providing education for all. Every child is given the rights as a citizen, including the right to access adequate and quality education. Inclusive education rejects dichotomies and discrimination because children are seen as having equal dignity and worth. Likewise with children with special needs such as autism, down syndrome, attention deficit hyperactivity disorder and other physical, mental and neurological obstacles. Differences in treatment encourage the presence of accompanying teachers for children with special needs at every school level. This qualitative study uses a narrative descriptive approach to explore the importance of accompanying teachers in supporting learning assistance for children with special needs. Data was obtained through field observations, interviews and documentation of 4 accompanying teachers with social work laboratory backgrounds and 2 class teachers at the school. The findings were obtained in conjunction with the data analysis process by the author as the main research instrument, seeing that accompanying teachers reflect each child's profile to accommodate needs, support learning and improve children's self-development skills activities.
Implementation of Learning Methods Based on Natural Materials and Science for Group B Kindergarten
Authors: Kurniawati Hartin , Husnayain Madani Ihda
Published: June 2024

The purpose of this research is to determine the application of the learning modelof natural materials and science centers for group B students in LestariKindergartens and to find out the supporting and inhibiting factors in theapplication of the learning model of natural materials and science centers inLestari Kindergartens. This research uses a qualitative approach that aims todescribe the processes that occur in the field. Data collection techniques arecarried out through observation, interviews, and documentation. The resulting datais then analyzed, through data reduction, data presentation, and conclusions usingqualitative descriptive analysis. The research results show: (1) The application ofnatural materials and science center learning includes: planning, implementationand evaluation. The implementation of central learning uses four steps startingfrom the playing environment, the steps before playing, the steps during play, andthe steps after playing. Evaluation of learning centers is carried out by observationand then assessed using checklists and anecdotes, as well as documentation in theform of work results. (2) Supporting factors in the application of natural materialsand science centers to science abilities, namely, the teacher's ability to masteradequate learning materials and learning media, while inhibiting factors in theapplication of natural materials and science centers to students' science abilities,namely: changing the K13 curriculum to a curriculum freedom to learn, facilitiesand infrastructure and children's activeness in participating in learning activities.Keywords: Learning Center Model, Natural Materials and Science Center, Child.
Testing and Comparing Antifungal Medications to Natural Remedies
Authors: Kyna Bhandari
Published: June 2024

This research paper aims to test and compare natural remedies to antifungal medications to see if they can be viable replacements for the medications. It aims to offer alternatives to people who may not have access to antifungal medications and avoid the overuse of medication. Through incubation, it found that garlic was an effective antifungal and the extent of its effect was the same as the antifungal medications, while castor oil and coconut oil were not as effective. Therefore, it states that garlic is a viable alternative to antifungal medications for yeast infections and encourages further testing to find more replacements for various types of infections.
Estratégias para Prevenção do Seroma em Pacientes Submetidos ao Tratamento Cirúrgico do Câncer de Mama: Revisão Sistemática da Literatura
Authors: Santos Danielle Vieira de Assis dos , Fabro Erica Alves Nogueira , Medeiros Costa Rejane , Nunes de Lucena Raphaela , Venda Marilucia Alves da , Torres Daniele Medeiros
Published: June 2024

Introdução: O seroma é a complicação cicatricial mais incidente no pós-operatório do câncer de mama que impacta a qualidade de vida dos pacientes, podendo levar à necessidade de punções repetidas, novos procedimentos cirúrgicos e a atrasos no tratamento adjuvante. Objetivo: Revisão sistemática da literatura científica sobre os procedimentos utilizados para prevenção do seroma em pacientes submetidos ao tratamento cirúrgico do câncer de mama, abordando suas vantagens e desvantagens. Método: Utilizou-se o método da Colaboração Cochrane, sendo incluídos artigos de ensaios clínicos e estudos observacionais. Para identificar estudos relevantes, pesquisaram-se as seguintes bases de dados: MEDLINE via PubMed, PEDro, Cochrane Library e LILACS. A busca foi realizada nos períodos de outubro de 2022 a janeiro de 2023. A qualidade metodológica dos ensaios clínicos foi avaliada pela escala PEDro e a dos estudos observacionais, pela escala de Newcastle-Ottawa. Resultados: Foram identificados 405 artigos e, após avaliação, incluídos 24 para serem analisados. Existem várias abordagens que poderiam minimizar a incidência de seroma, como o uso de dreno, obliteração do espaço morto, os instrumentos utilizados para a dissecação tecidual e as técnicas que poderiam controlar o processo inflamatório. Conclusão: As estratégias de prevenção do seroma utilizadas nos estudos incluídos minimizaram sua incidência, com exceção do talco e do iodo, entretanto, os estudos que tiveram como objetivo a obliteração do espaço morto, seja com sutura quilting ou selante, mostraram resultados estatísticos mais significantes, sugerindo serem promissores para a prevenção do seroma.
Daya Tarik Wisata Musik dalam Meningkatkan Kunjungan Wisatawan ke Kota Bandung
Authors: Alim Azmi Kautsar , Noor Any Ariani
Published: June 2024

Today, music tourism is multiplying due to a shift in tourism trends from mass tourism to more personalized tourism activities or special interest tourism. This shift in tourism trends has a positive impact on the city of Bandung, which is famous for the creativity of its young people and produces many famous musicians and music festivals in Indonesia. This study aims to identify the influence of music tourism attraction on the motivation of tourists visiting Bandung. Mixed methods through in-depth interviews with music tourism providers and distributing questionnaires to 100 respondents who have attended music performances in the city of Bandung were used to collect comprehensive and in-depth data. The results show that the city of Bandung has fulfilled the four components of tourism. Meanwhile, the results of the quantitative analysis show that music tourism has the potential to influence the motivation of tourists visiting Bandung City.
Analisis Perputaran Karyawan (Labour Turnover) Hotel Berbintang Di Kota Jember
Authors: Jatmiko Hadi , Sandy Syah Riza Octavy
Published: June 2024

This research aims to analyze the labour turnover of Star Hotels in Jember City. The research population was employees of star hotels in Jember City, referring to PHRI Jember data, there were 5 star hotels in Jember City with a total of 162 employees. The sample for this research was some employees of star hotels in Jember City. The sampling method used was the quota sampling method, namely a predetermined/rationed sample collection method. The sample size was determined at 60 respondents, which was based on the rule that the sample size was at least 15 times the variables. Structured interviews with hotel managers and management associations. The data analysis technique used in this research is multiple linear regression. Result of statistical analysis shows that the compensation factor variable has a negative and significant effect on labour turnover, the career path variable has a negative and significant effect on labour turnover, the work stress variable has a positive and significant effect on labour turnover.
Pelatihan Kepatuhan Koperasi Terhadap Penyelenggaraan Pengembangan dan Penguatan Sektor Keuangan
Authors: Irawan Dandan
Published: June 2024

Law Number 4 of 2023 concerning the Development and Strengthening of the Financial Services Sector (UU PPSK) is the initiative of the Government and the DPR to advance public welfare by reforming the Indonesian financial sector. Compromises for Savings and Loans (KSP) and Savings and Loan Units (USP) operations are divided into closed loops where KSP and USP are supervised by the Ministry of Cooperatives and of course, internal cooperatives and opened loop for KSP and given a two-year transition period to become a Financial Services Cooperative supervised by the Financial Services Authority (OJK). This study recommends that the regulation and supervision of cooperative savings and loan business activities be more suitable for the Government on the grounds of the context of cooperative development, democracy, social inclusion, local culture, history, regulation, and taking into account lessons learned experiences of other countries in developing cooperatives. While the regulation and supervision of financial services businesses by cooperatives is more suitable to be supervised by the OJK on the grounds that financial service cooperatives can raise public funds and protect consumers who use financial services. The PPSK Bill contains a number of articles on technical matters that should be sufficiently regulated in the PP. The PPSK Bill needs to accommodate the voices and aspirations of the cooperative movement aimed at encouraging the growth of supporting institutions needed by KSP/USP and Financial Services Cooperatives. Methods Training is carried out using a participatory method that allows participants to interact directly with the trainers/instructors
Pendampingan Pengembangan Karakter Individu Sebagai Penggiat Pencegahan Pemberantasan Penyalahgunaan dan Peredaran Gelap Narkotika (P4GN) Pada Kalangan Masyarakat di Kabupaten Bogor
Authors: Nur Laela Ermaya Husnah , Kalifatullah Ermaya Sir
Published: June 2024

The circulation of illegal drugs continues to increase every year. The volume of drug circulation is directly proportional to the number of users. Bogor Regency has the second highest number of drug cases in West Java (Jabar). A total of 170 drug cases have been handled by the police in 2022. The Bogor Police Narcotics Unit throughout the year has been trying to reduce the number of drug users and dealers by carrying out preventive efforts in collaboration with other stakeholders. This activity aims to provide education to all participants who attend about the impacts of using illegal drugs and how to overcome them. Apart from that, it also forms the individual character of every P4GN activist in Bogor Regency.
Coding for Kids sebagai Proses Pengenalan Pemrograman Komputer bagi Siswa Sekolah Al Masduqi Boarding School (AMBS) - Garut
Authors: Nugraha Agus
Published: June 2024

The teaching and learning process (PBM) for students at Al Masduqi Boarding School (AMBS) - Garut is held intra-curricular and extra-curricular. One of the extra-curricular activities (ekskul) is Coding for Kids (Ekskul Koding) where this activity is managed by the school involving a team that is competent in the field of computer programming. As a PBM, the implementation of coding extracurricular activities must consider and implement the functions of primary and secondary education. The team plans this by preparing Terms of Reference (ToR) which contain the background, aims and objectives, educational methods and the team and instructors involved and the overall series of activities. In the Odd Semester of the 2023/2024 Academic Year, as many as 8 students took part in this activity which was guided by 1 – 2 instructors with a meeting frequency of once a week for an average of 90 minutes. During activities, students are monitored and evaluated by a team consisting of Deputy Director I for Curriculum, Extra-Curricular Coordinator and Instructor.
Peningkatan Pemahaman Kesiapan Berwirausaha bagi Pegawai Pada Masa Purna Tugas
Authors: Indriani Yuanita
Published: June 2024

Retirement is a period that will be experienced by all employees who have reached retirement age. This condition is often a hot topic of conversation among employees, especially employees who will soon enter retirement. People often think that entering the retirement period is a period of rest and is not productive, giving rise to feelings of doubt and anxiety. The employee's mental image of the retirement period is a time when there is no busyness or even no activity, even though physically and mentally the employee feels that he still has the ability to carry out productive activities. The DKI Jakarta Raya Provincial Employee Cooperative (KPPD) is a functional cooperative whose members are employees who work within the DKI Jaya Provincial Government. As a functional cooperative, KPPD has different membership characteristics when compared to other cooperative members, in this case, KPPD members have a limited working age in accordance with applicable laws and regulations, so KPPD considers it necessary and important to equip members who will enter retirement. Efforts to equip members who will enter retirement are carried out by KPPD through entrepreneurship training. This activity aims to increase the readiness of members to enter retirement. The readiness of members to fill their retirement period is shown by how members plan and take concrete steps to fill their retirement period, through training activities. It is hoped that entrepreneurship training will be able to provide insight and inspire members to have concrete plans for completing their retirement period, in an effort to reduce members' worries and anxiety in filling their retirement period comfortably.
Pendidikan Perkoperasian "Dasar Perkoperasian, Kelembagaan Koperasi dan Usaha Koperasi" Bagi Calon Anggota di SMK Koperasi, Daerah Istimewa Yogyakarta
Authors: Kalifatullah Ermaya Sir
Published: June 2024

The number of cooperatives in Indonesia continues to increase rapidly, but there are still many cooperative members and employees who do not understand the principles of cooperatives, so many cooperatives are not active. One of the cooperatives in Daerah Istimewa Yogyakarta is the Employee Cooperative at SMK Cooperative, Yogyakarta. The Community Service Team provides guidance in the form of material regarding the basics of cooperatives, cooperative institutions, and cooperative businesses so that prospective members can participate better and employees work more actively to improve their performance. Some of the cooperative theories provided in this Community Service activity are basic cooperatives, definition of cooperatives, foundation, principles and objectives for establishing cooperatives, cooperative principles, characteristics of cooperatives, types of cooperatives, and business activities in cooperatives. In practice, there needs to be a strengthening of prospective members so that they have strong motivation to cooperate. It is hoped that educational development for employees and prospective members will be able to contribute to all levels of management, employees, and members.
РОЗВИТОК ПЕДАГОГІЧНОЇ ТЕРМІНОЛОГІЇ ТА СТАНОВЛЕННЯ ПОНЯТІЙНО-КАТЕГОРІАЛЬНОГО АПАРАТУ ПЕДАГОГІКИ
Authors: МАРЧУК Сергій , КАБАК Віталій , БОРБИЧ Наталія , КОВАЛЬЧУК Ірина
Published: June 2024

У статті проаналізовано розвиток педагогічної науки як особливої соціальної сфери, спрямованої на виховання людини. Визначено походження терміну «педагогіка». Звернено увагу на становлення понятійного апарату педагогіки як складової її методології. Зародившись у лоні філософії, педагогіка стала самостійною галуззю наукових знань, обґрунтованих у працях Я. Коменського. Встановлено, що педагогіка має виступати як теоретична, фундаментальна, прикладна і практично орієнтована наука. Висвітлено сутність, походження та джерела світової та української педагогічної термінології. Розглянуто сутність поняття «педагогічна термінологія» як системи лексичних засобів і найменувань, застосовуваних для опису теорії і практики виховання, навчання і освіти. З’ясовано генезу української педагогічної термінології. Першим терміном, зафіксованим у «Повісті минулих літ», є «книжне вчення». Чимало педагогічних термінів розглянуто в першому українському словнику «Лексиконі» П. Беринди: «педагог», «дітоводець», «пестун», «дітоучитель». Наведено терміни для визначення різних вікових груп: «пеленчатко», «немовлятко», «дитя», «дітище», «чадо», «отроча», «юноша». Наукові засади педагогіки розроблені видатним українським педагогом К. Ушинським у праці «Людина як предмет виховання. Спроба педагогічної антропології». Термін «педагогія» зустрічається у праці О. Духновича «Народна педагогія». Розглянуто різні підходи до наповнення понятійно-категорійного апарату педагогіки. Найважливіші педагогічними категоріями визначено такі поняття як виховання, освіта, навчання. Окрім того, названо найзагальніші поняття, що мають фундаментальне значення – виховання, освіта, навчання, самоосвіта, самовиховання, соціалізація, розвиток, формування особистості. Здійснене дослідження не вичерпує всіх наукових аспектів обраної педагогічної проблеми. Подальшого вивчення потребують питання інтеграції змісту базових категорій педагогіки в сучасне освітнє законодавство України.
ІМПЛЕМЕНТАЦІЯ ПЕДАГОГІЧНИХ ІДЕЙ О. ПОПОВИЧА В УМОВАХ МОДЕРНІЗАЦІЇ НОВОЇ УКРАЇНСЬКОЇ ШКОЛИ
Authors: РОМАНЮК Світлана , ВЕРБЕЦЬ Владислав
Published: June 2024

У статті акцентується увага на педагогічній спадщині відомого учителя-практика. автора шкільних підручників, громадсько-просвітницького та культурного діяча Омеляна Поповича в контексті розвитку Нової української школи. Обґрунтовано актуальність його дидактичних ідей у навчанні рідної мови молодших школярів, які не втратили свої значущості на сучасному етапі, урізноманітнення принципів, методів і форм навчання та організації освітнього процесу в початковій школі. Доведено, що провідними принципами мовної освіти є збагачення словникового запасу учнів на основі вивчення творів художньої літератури, активізація розвитку мислення і мовлення школярів, реальні ситуації спілкування і важливий з-поміж них принцип зв’язку навчання з життям. Актуальними для сучасних реалій вважаємо міркування О. Поповича щодо використання експериментальних, практичних методів навчання, які суголосні з сучасними проєкними, інформаційно-комунікаційними технологіями. Розкрито можливість творчого використання педагогічних ідей О. Поповича у підготовці сучасного вчителя початкової школи, створення підручників нового покоління для молодших школярів. Так, на думку педагога шкільні підручники мають враховувати вікові особливості дітей і написані зрозумілою, доступною для них літературною українською мовою, побудовані на краєзнавчому матеріалі, реалізуючи національне виховання. Обґрунтовано властивості особистості вчителя (особистісні, професійні, морально-етичні), які є суголосними вимогам сьогодення і складають основу професійного стандарту «Вчитель початкових класів закладів загальної середньої освіти». Метою публікації є обґрунтування доцільності імплементації педагогічних ідей О. Поповича в освітній процес сучасної початкової школи та підготовки майбутніх вчителів початкових класів закладів загальної середньої освіти в умовах викликів сьогодення. Перспективами подальшого дослідження визначено виховний потенціал літературного доробку педагога у формуванні національної свідомості зростаючої особистості.
ЗАСТОСУВАННЯ ПРОБІОТИЧНОЇ ДОБАВКИ ЗА КЕТОЗУ КОРІВ
Authors: Скляр Олександр Іванович , Грек Вікторія Анатоліївна
Published: June 2024

Проблема лікування кетозу постає часто після отелення, особливо у високопродуктивних корів. В роботі представлені результати лікувального ефекту зразків штамів Bacillus subtilis АХ 20, Bacillus licheniformis ЕА 22 за кетозу у корів. Мета дослідження полягала у визначення терапевтичної дози пробіотичної добавки для лактуючих корів. Експеримент був проведений у господарстві, де утримують корів породи голштин. Хворих на кетоз корів дослідних груп годували концентрованими кормами з додаванням Bacillus subtilis АХ 20, Bacillus licheniformis ЕА 22 (1×109 КУО/г) в розрахунку 15-35 г на кожну тварину. Тривалість дослідження склала тридцять діб. Застосування 15 г пробіотику коровам сприяло зниженню рівня кетонів на п’яту добу на 125 %, на п’ятнадцяту – на 100 %, на 30 – на 42,85 %, порівняно з контролем. З додаванням 25 г пробіотику знизився рівень кетонів на п’яту добу на 125 %, на п’ятнадцяту – на 114,28 %, на 30 – на 28,57 %. У дослідній групі корів з додаванням 35 г вміст β-кетонів знизився на п’яту добу на 125 %, на п’ятнадцяту – на 71,42 %, на 30 аналогічно контролю. Рівень β-кетонів в крові контрольної групи тварин відповідав фізіологічній нормі (1,0 ммоль/л). Дослідженнями доведено, що на 30 добу дослідження рівень кетонових тіл у всіх тварин відповідав фізіологічній нормі. Застосування коровам пробіотику у дозі 35 г сприяло максимальнму збільшенню кількості Lactobacillus sp. на 64 %, Bifidobacterium на 58 %, порівняно з контрольною групою. Також суттєво знизився вміст Escherichia coli – на 45 %, Clostridium – на 27 %, Enterobacteriaceae та Staphylococcus– на 75 %, Candida – на 80 %. В результаті застосування пробіотику коровам у дозі 15 г у групі на п’ятнадцяту добу досліджень кМАФАнМ зменшилось на 14,48 %, КСК – на 26,55 %. На тридцяту добу експерименту кМАФАнМ зменшилось на 40,45 %, КСК – на 45,59 %, порівняно з початком досліджень. У молоці корів за використання пробіотику в дозі 25 г на п’ятнадцяту добу зменшилась кількість кМАФАнМ на 21,2 % та КСК на – 58,2 %, на тридцяту добу кМАФАнМ на 40,51 %, КСК – на 62,48 %, на порівняно до початку дослідження.
ОСОБЛИВОСТІ АНАТОМІЧНОЇ БУДОВИ КАРАСЯ ЗВИЧАЙНОГО
Authors: Плюта Лариса Василівна
Published: June 2024

Риби відносяться до царства тварин, водних хребетних тварин, ряд коропоподібні, родина коропові, вид карась звичайний. Скелет риб складається з осьового скелету тулуба, скелету органів руху плавців (скелет кінцівок) та черепа. Осьовий скелет карася має два відділи тулубовий та хвостовий. Основу його складає хребетний стовбур утворений кістковими хребцями, які з’єднані між собою, а в тулубовому відділі є ребра, які розташовані по бокам і захищають внутрішні органи риби. В результаті наших досліджень були встановлені особливості будови форми тіла карася звичайного. При цьому застосовували комплекс стандартних морфологічних методів досліджень. Використовували комплексні класичні морфологічні, анатомічні методи експериментальних досліджень, які включали: зовнішній огляд досліджуваного об'єкта, препарування органів, їх абрис (колір, консистенція, форма), виявлення топографічних особливостей з урахуванням опису організму по його контурах, фотографували його, що в кінцевому підсумку дозволило провести ретельне макроскопічне дослідження соматичної системи у карасів. Будова тіла карася звичайного білатерально симетрична і для опису інших органів ми використовуємо тримірний вимір, тобто відносно трьох площин. Тіло карася має гарно розвинену головну ділянку, спинку з легким вигином, приплюснуту вентральну частину тулуба та гарно розвинений хвіст. Колір карасів коливається від сріблясто-жовтого до бронзового в залежності від роду. Окрас більш темніший в дорсальній частині ніж в вентральній. Карась має головну ділянку, тіло та хвіст. На головній ділянці карася розрізняють рот, парні носові отвори, зяброві отвори та очі. Тіло та хвіст карася звичайного ззовні вкриті кістковою лускою, яка щільно прилягають один до одного, а вентрально за головною ділянкою формується більш щільніша пластинка з луски від грудних плавців латеромедіально. На тілі карасів гарно видно безперервну шкірну складку по медіальній лінії дорсально вздовж спини, а потім вона переходить вентрально до анального отвору і утворює непарні плавці. Від анального отвору вентрально розташовані парні плавці. Основна функція плавців це регуляція руху риби в певному порядку та напрямку, підтримка рівноваги у воді. Плавці у карася парні це спинний, хвостовий та анальний, та непарні це грудні та черевні. На спинці дорсально розташований непарний спинний плавець, він довгий, гарно розвинений і зменшується в бік хвоста, його перші промені тверді і перший має зазубрени на каудальном у краї. Хвостовий плавець має вигляд оберненої трапеції, має дві лопасті, ним закінчується хвостова ділянка. Парний грудний плавець розташовується каудально від зябрових отворів по бокам, а за ним вентральніше виступають черевні плавці, які лежать горизонтально. Анальний плавец розташований вентрально на межі тіла та хвоста, промені розгалужені. На ділянці голови каудально по бокам розташована гарно розвинена парна зяброва щілина права та ліва. Вона розташована вертикально і її нижній кінець доходить майже до кута губ, а аборально формує межу тіла та голови. Її прикриває зяброва кришка яка формує бічну поверхню голови.
Optical and Electrical properties of organic Aluminum phthalocyanine based thin films for organic electronics.
Authors: Benhaliliba Mostefa
Published: June 2024

Thought this research, the optical and electrical properties of organic aluminum phthalocyanine (AlPc) molecule based thin film are emphasized. The transmittance of such materials presents a narrow peak  and valley within a range of 446 nm. Dielectric parameters like refractive and extinction coefficient are studied within Uv-vis-IR range. Optical band gap and Urbach energy are determined found to be 2.6  eV and 33 meV. Based on single oscillator, dispersion energy and related parameters like E0, Ed, S0, l0, n0, epsil,
ЕКОЛОГІЧНА КОМПЕТЕНТНІСТЬ СУДНОВОДІЇВ В УМОВАХ СТАЛОГО РОЗВИТКУ
Authors: Герлянд Татьяна
Published: June 2024

Relevance: Under current conditions, the problem of ship navigation gains particular relevance – the formation of ecological competence of ship operators in the context of sustainable development, the study of important aspects of the interaction of vessels and the surrounding environment, particularly their impact on water resources, water pollution, emissions of harmful substances, and other ecological aspects.
Objective: To determine the role of ecological competence of ship operators in the context of sustainable development.
Methods: Theoretical methods: analysis, synthesis, generalization of scientific works on the issue of ecological competence of future professionals in the field of ship navigation and official documents – to define the theoretical and methodological bases of the phenomenon; study and generalization of the existing problem status with the aim of choosing pedagogical tools – for the development of ecological competence of ship operators; comparison – to identify various approaches to solving the researched problem; modeling – to justify the structural elements of the model for the development of ecological competence of ship operators.
Results: Key characteristics of ecological competence and its components have been identified; ecological competence of ship operators is considered as a complex integrative characteristic of the personality, reflecting motives of ecological activity, possession of ecological knowledge and natural science bases, practical skills and abilities regarding environmental protection; the necessity of forming ecological competence in ship operators during their professional training has been substantiated, as it directly affects the conservation of the marine water state, protecting them from pollution. It is noted that under current conditions, when sustainable development has become one of the priority directions of global policy, the ecological competence of ship operators is a key factor in ensuring safe navigation, and ecological education in the maritime sector is an important tool for forming this competence in ship operators.
Conclusions: Education acts as a catalyst for the development of sustainable thinking and practices in the maritime sector, promoting ecological safety and sustainable development in this strategically important industry; as the maritime sector continues to develop, the results of the conducted research emphasize the important role of education in preparing future ship operators to navigate the ecological complexities of the global maritime industry and to contribute to sustainable development and effective communication.
An Evaluation of Water Quality and Accessibility in Nepal: A Study of Three Areas: Kaski, Terai, and Kathmandu
Authors: Udas Anugraha
Published: June 2024

The purpose of this major research paper was to gain an understanding of the water crisis that exists in Nepal, specifically, how the quality of water and accessibility to natural water resources differs between three areas. The evaluated areas comprise Kaski, Terai, and Kathmandu. The creation of a water quality index and distance accumulation spatial analysis techniques, indicates that Kaski has the highest quality of water while placing second for accessibility. Terai ranks second for water quality, with the highest number of settlements with natural water accessibility. Kathmandu has the worst water quality and the least number of settlements in proximity to natural water resources. Since such a wide disparity exists, further research needs to be conducted to investigate possible correlations between the aforementioned variables and socioeconomic differences. In doing so, mitigative techniques can be devised to ensure that the Nepali population, regardless of class, have access to clean drinking water.
Against Anxious Spaces: Disrupting the Commodification of Architecture
Authors: Abuaboud Dareen
Published: June 2024

Architecture aims to improve life on numerous levels and design the best possible future for people and society. However, this effort often is challenged when architecture is instead deployed to service economic activities. The burgeoning spaces of transit and commerce, including

shopping malls, are examples of the commodification of architecture. Within burgeoning spaces, users are passive, often disoriented and constrained to stay in a state of perpetual consumption. The anxiousness of the 21st century is reflected in these spaces where people's interests beyond their role as consumers are not considered.

This thesis aims to decommodify the burgeoning spaces. It deploys evidence-based research and analytical studies to analyze the effects of the commodification of architecture on users' behaviours and interactions with the built environment. By deploying the disprogramming and the social condenser theories, the design aims to disrupt the spatial qualities of commodification. The Eaton Centre and its surroundings is the location of a speculative design project which aims to break the commodification of architecture by contaminating its main circulation spaces with active social and cultural (non-commodified) programs.
The Involvement of Adaptor Protein Complexes in Phagocytosis
Authors: Butt Muhammad
Published: June 2024

Phagocytosis is an essential process involved in innate immunity in multicellular organisms. It is a multi-stage process starting with phagocytic uptake, followed by phagosome maturation, and finally phagosome resolution. The first two stages of phagocytosis have been studied thoroughly over the past decades but very little is known about the terminal phagosome resolution stage. The discovery of clathrin involvement in phagosome resolution has raised new speculations of the involvement of other membrane fission proteins such as the Adaptor Protein (AP) complexes some of which recruit clathrin to drive fission events inside the cell. Therefore, we aimed to study the involvement of AP-1, AP-2, and AP-3 in phagosome resolution. However, to account for downstream effects on phagosome resolution due to altered phagocytic uptake and phagosome maturation, we conducted research to explore the effects of silencing AP-1, AP-2, and AP-3 at each of the three main stages of phagocytosis. Our data reveal a role for AP-2 and AP-3 in phagocytic uptake, a role for AP-1 in phagosome maturation, and a novel role for AP-2 and AP-3 in phagosome resolution in a clathrin-dependent and clathrin-independent manner, respectively. Our observations will have a significant impact on future work concerning the molecular machinery involved in phagosome resolution as well as subsequent investigations studying the involvement of AP complexes in phagocytic uptake and phagosome maturation.