bluuebunny/crossref_metadata_2025 huggingface dataset:
Men's Reproductive Health: Oxidative Stress and the Effectiveness of Antioxidant Therapy
Authors: Kurashova Nadezhda A. , Dashiev Bair G. , Kudeyarova Ekaterina  A. , Kolesnikova Lyubov I.
Published: September 2021

This review article surveys and summarizes the literature data concerning the problems of deterioration of the main indicators of men's reproductive health and the effectiveness of therapy with drugs with antioxidant properties. The analysis of domestic and foreign literature confirms that oxidative stress (OS) accompanies and/or is one of the pathogenetic links in the development of many types of reproductive pathology in men. The health status of the male population is influenced by the following factors: lifestyle, existing diseases, the state of the environment, and the genotype of the population. The interaction of several weak, but unidirectional, factors creates a high risk of developing male reproductive pathology. The polyetiological nature of fertility disorders in men causes certain difficulties in creating adequate methods of treating this pathology and causes multicomponent biocomplexes to appear on the pharmaceutical market that contain active substances that can affect the quality of the ejaculate.
The Diagnostic Value of the Leukocyte Shift Index in Purulent-Septic Rhinosinusogenic Complications in Children
Authors: Kuznetsova Tatiana B. , Ponomareva Maria N. , Kuznetsova Nadezhda E.
Published: September 2021

The aim of this study was to investigate the diagnostic value of the leukocyte shift index (LSI) in inflammatory pathology of the paranasal sinuses (PNS) with the rhinosinusogenic orbital complications (RSOC) in pediatric patients. Methods and Results: The study involved 50 patients (26 boys and 24 girls) with diseases of the PNS and RSOC (reactive edema of the eyelids, orbital tissue, and purulent-septic complications of the eyelids and orbit) aged from 1 to 17 years (mean age of 6.66±0.63 years). Group 1 included 29 patients (16 boys and 13 girls) with reactive edema of the eyelids and orbital tissue. Group 2 included 21 patients (10 boys and 11 girls) with purulent-septic RSOC. As a marker for determining the activity of the inflammatory process and the disorders of the immunological reactivity of the body, LSI (leukocyte shift index) was calculated. In general, the LSI value was 1.61±0.21 in Group 1 and 3.45±0.49 in Group 2 (P=0.001). Among patients aged between 3 and 12 years, the LSI was 1.66±0.30 in Group 1 and 3.93±0.79 in Group 2 (P=0.012). The results obtained indicate that LSI can be used to predict purulent-septic RSOC in inflammatory diseases of PNS in patients aged between 3 and 12 years. LSI values from 1.36 to 1.96 may predict the development of reactive edema of the eyelids and orbital tissue; from 3.14 to 4.72 - the development of purulent-septic complications of the eyelids and orbit. Conclusion: The results obtained can be useful in predicting the clinical course of the RSOC in inflammatory pathology of PNS in patients in the age group of 3-12 years.
Risk Factors and Causes of Fever after Endoscopic Submucosal Dissection
Authors: Chen Ming , Liu Jinqi , Zhang Xiaoxue , Wang Dongyang , Wang Haipeng , Dong Guangfeng , Zhai Huizhuan , zengjun Li
Published: September 2021

Background To investigate the fever and related risk factors of gastrointestinal mucosa or submucosal lesions after endoscopic mucosal dissection(ESD).Method A retrospective analysis of patients undergoing ESD. Patients were divided into two groups according to the presence or absence of post-ESD fever. Patient-related factors and lesion-related factors were counted in both groups.Results The incidence of fever was 31.0% in 290 patients after the operation, 87 patients developed fever within 24 hours after operation. The average of (2.82 ± 1.186) days. According to logistic analysis, the surgical site was in the esophagus (OR value: 6.439; 95% CI: 2.030-20.424; P value: 0.002), with diabetes history (OR value: 3.289; 95% CI: 1.015-10.662; P value: 0.047), age≥70.6 years (OR value: 0.844; 95% CI: 0.805-0.884; P value: 0.000), resection diameter> 4.25 mm (OR value: 2.361; 95% CI: 5.202-29.371; P value: 0.000), operation time> 196min (OR value: 1.022; 95% CI: 1.003-1.042; P value: 0.022) were risk factors for fever.Conclusions Older patient, the operation site in esophagus, diabetes, large tumors and long operation time were more likely to develop post-ESD fever, The possibility of bacteremia after ESD is small, antibiotics do not need to be applied in advance.
Integration of Transcriptomic And Proteomic Analyses Reveals Several Levels of Metabolic Regulation In The Excess Starch And Early Senescent Leaf Mutant lses1 In Rice
Authors: Chen Zhiming , Wang Yongsheng , Huang Rongyu , Zhang Zesen , Huang Jinpeng , Lin Yaohai , Guo Yuchun , Liang Kangjing , Zhou Yuanchang , Chen Fangyu
Published: September 2021

Background: The normal metabolism of transitory starch in leaves plays an important role in ensuring photosynthesis, delaying senescence and maintaining high yield in crops. OsCKI1 (casein kinase I1) plays crucial regulatory roles in multiple important physiological processes, including root development, hormonal signaling and low temperature-treatment adaptive growth in rice; however, its potential role in regulating temporary starch metabolism or premature leaf senescence remains unclear. To reveal the molecular regulatory mechanism of OsCKI1 in rice leaves, physiological, transcriptomic and proteomic analyses of leaves of the mutant lses1 (leaf starch excess and senescence 1), allelic to osckI1, and its wild-type variety (WT) were performed. Results: Phenotypic identification and physiological measurements showed that the lses1 mutant exhibited starch excess in the leaves and an obvious leaf tip withering phenotype as well as high ROS and MDA contents, low chlorophyll content and protective enzyme activities compared to WT. Transcriptomic and proteomic analyses showed that the correlations of most genes at the transcription and translation levels were limited. However, the changes of several important genes related to carbohydrate metabolism and apoptosis at the mRNA and protein levels were consistent. The protein-protein interaction (PPI) network might play accessory roles in promoting premature senescence of lses1 leaves. Comprehensive transcriptomic and proteomic analysis indicated that multiple key genes/proteins related to starch and sugar metabolism, apoptosis and ABA signaling exhibited significant differential expression. Abnormal increase in temporary starch was highly correlated with the expression of starch biosynthesis-related genes, which might be the main factor that causes premature leaf senescence and changes in multiple metabolic levels in leaves of lses1. In addition, significant up regulation of four proteins associated with ABA accumulation and signaling were detected in the lses1 mutant, suggesting that ABA may involve in multiple metabolic regulation via LSES1/OsCKI1 and the formation of mutant phenotype in lses1 leaves.Conclusion: The current study established the high correlation between the changes in physiological characteristics and mRNA and protein expression profiles in lses1 leaves, and emphasized the positive effect of excessive starch on accelerating premature leaf senescence. The expression patterns of genes/proteins related to starch biosynthesis and ABA signaling were analyzed via transcriptomes and proteomes, which provided a novel direction and research basis for the subsequent exploration of the regulation mechanism of temporary starch and apoptosis via LSES1/OsCKI1 in rice.
The return of chloroquine-sensitive Plasmodium falciparum parasites in Jazan Region, Southwestern Saudi Arabia over a decade after the adoption of artemisinin-based combination therapy: analysis of genetic mutations in the pfcrt gene
Authors: Madkhali Aymen M. , Abdulhaq Ahmed A. , Atroosh Wahib M. , Ghzwani Ahmad Hassn , Zain Khalid Ammash , Ghailan Khalid Y. , Hamali Hassan A. , Mobarki Abdullah A. , Eisa Zaki M. , Lau Yee-Ling , Al-Mekhlafi Hesham
Published: September 2021

This study investigated the polymorphism in the P. falciparum chloroquine resistance transporter (pfcrt) gene 11 years after chloroquine (CQ) cessation in Jazan region, southwestern Saudi Arabia. Two hundred and thirty-five P. falciparum isolates were amplified to detect mutations in the pfcrt gene. The pfcrt 76T molecular marker for CQ resistance was detected in 66.4% (156/235) of the isolates, while the K76 CQ-sensitive wild type was detected in 33.6%. The pfcrt 74I and pfcrt 75E point mutations were each found to be present in 56.2% of isolates, while only four isolates (1.7%) were found to carry the pfcrt 72S mutation. Moreover, four pfcrt haplotypes were identified: the CVIET triple-allele (56.2%), SVMET double-allele (1.7%), and CVMNT single-allele (8.5%) mutant haplotypes, and the CVMNK wild haplotype (33.6%). The analysis also revealed significant associations between the prevalence of mutant pfcrt alleles and haplotypes and the age group, governorate, and nationality of the patients as well as the parasitaemia level (P < 0.05). The findings provide evidence of the potential re-emergence of CQ-susceptible P. falciparum strains in Jazan region over a decade after CQ discontinuation, with about one third of the isolates analysed carrying the pfcrt K76 CQ-sensitive wild allele and the CVMNK ancestral wild haplotype. Although the reintroduction of CQ cannot be recommended at present in Saudi Arabia, these findings support the rationale for a potential future role for CQ in malaria treatment. Therefore, continuous molecular and in-vitro monitoring mutations of pfcrt polymorphism in Jazan region is highly recommended.
Investigation On Ultra-Compact, High Contrast Ratio 2d-Photonic Crystal Based All Optical 4 x 2 Encoder
Authors: Kumar R. Arun , V Kavitha , K Rama Prabha , K Latha , S Robinson
Published: September 2021

Optical encoder is playing an essential starring role in optical communication and computing applications. This paper presents a new structure for 4 x 2 optical encoder based on Two Dimensional Photonic Crystals (2DPC). The proposed structure consists of silicon rods in background of air using hexagonal lattice. The proposed structure is composed of four input waveguides and two outputs. The band structure is examined by Plane Wave Expansion (PWE) method and the performance parameters of the 4x2 encoder, namely, normalized output power, footprint, contrast ratio, response time and bit rate are analyzed using Finite Difference Time Domain (FDTD) method. The proposed encoder is operated at 1550nm. The low response time, and small footprint have shown that the encoder is exceptionally suitable for high performance optical networks and photonic computational integrated devices.
Five Years Sustained Clinical Safety and Efficacy of An Abluminal Biodegradable-Polymer Coated Sirolimus-Eluting Stent: A Randomized Controlled Trial
Authors: cao mingkun , Yin Yuxia , Zhou Chao , Deng Wei , Ma Jianying , Zhang Feng , Yao Kang , Toft Egon , Ge Junbo , Zhang Haijun
Published: September 2021

Background
Drug-eluting stent (DES) with durable polymers have been proven to cause late or very late adverse events. Biodegradable polymer-coated DES was developed to address the risk by avoiding persistent inflammatory irritation from persistent polymers. However, it is unknown whether the benefits of biodegradable polymer DES will occur over longer time.
Methods
The trial was a prospective, multicenter and randomized non-inferiority clinical trial done in China. Patients with indications for stent implantation were assigned into Cordimax and Xience V group in a 2:1 allocation. The composite of cardiac death, target vessel myocardial infarction (TV-MI), or clinically indicated target lesion revascularisation (CI-TLR) was the primary endpoint target lesion failure (TLF). The pre-specified endpoint at five years was major adverse cardiac event (MACE) which was defined as a composite of all-cause death, non-fatal myocardial infarction (MI), and CI-TLR.
Results
3266 patients (88.3%) completed 5-year follow-up. No difference was observed for TLF between Cordimax (7.5%) and Xience V (8.3%) group (RR: 0.90, 95% CI: 0.70 to 1.15, P = 0.39). MACE occurred in 280 patients (11.4%) in Cordimax group and 162 patients (13.1%) in Xience V group (RR: 0.85, 95% CI: 0.69 to 1.05, P = 0.13). The incidence of definite or probable stent thrombosis did not differ in both groups (Cordimax 0.7%, Xience V 0.9%; RR: 0.78, 95% CI: 0.36 to 1.66; P = 0.51).
Conclusion
The biodegradable polymer Cordimax stent showed a comparable result to the durable polymer Xience V stent at 5 years, showing its long-term safety and efficacy performance.
Trial registration:
This study is registered with ClinicalTrials.gov, number NCT03185221 (14/06/2017).
Human seasonal influenza under COVID-19 and the potential consequences of influenza lineage elimination
Authors: Dhanasekaran Vijaykrishna , Sullivan Sheena , Edwards Kimberly , Xie Ruopeng , Khvorov Arseniy , Valkenburg Sophie , Cowling Benjamin , Barr Ian
Published: September 2021

Annual epidemics of seasonal influenza cause hundreds of thousands of deaths, high levels of morbidity, and substantial economic loss. Yet, global influenza circulation has been heavily suppressed by public health measures and travel restrictions since the onset of the COVID-19 pandemic. Notably, the influenza B/Yamagata lineage has not been conclusively detected since April 2020, and A(H3N2), A(H1N1), and B/Victoria viruses circulate with considerably less genetic diversity. Travel restrictions have largely confined regional outbreaks of A(H3N2) to South and Southeast Asia, B/Victoria epidemics in China, and A(H1N1) in West Africa. Seasonal influenza transmission lineages continue to perish globally, except in select hotspots, which will likely seed future epidemics. Waning population immunity and sporadic case detection will further challenge influenza vaccine strain selection and epidemic control. We offer perspective on the potential short- and long-term evolutionary dynamics of seasonal influenza and discuss potential consequences and mitigation strategies as global travel gradually returns to pre-pandemic levels.
Reduced Levels of A20 Protein Prompted RIPK1-Dependent Apoptosis of Vascular Endothelial Cells and Blood–Brain Barrier Breakdown in CIRI
Authors: Li Ying , Yang Chaonan , Yang Yuting , Li Huijie , Wu Xiaohui , Gong Min
Published: September 2021

Blood–brain barrier (BBB) leakage is an important cause of the exacerbation of pathological features of ischemia and reperfusion. However, the specific mechanism of cell death of vascular endothelial cells is not clear. It was found that ischemic reperfusion resulted in RIPK1 activation in vascular endothelial cells and induced cells to undergo subsequent RIPK1-dependent apoptosis (RDA). Inhibition of RIPK1 significantly reduced BBB breakdown and brain damage. The aim of this study is to investigate the mechanism of RIPK1 in the BBB leakage during the ischemia reperfusion procedure.In this study, the role of RIPK1 in the development of cerebral ischemia reperfusion injury (CIRI) was investigated by immunohistochemical approaches on KO or mutant mice. It was discovered by proteomics that autophagy activation resulting from ischemia and reperfusion significantly downregulated the level of A20 protein in vascular endothelial cells. A20 is an important protein that regulates RIPK1 and RDA. It was hypothesized that activation of autophagy in vascular endothelial cells caused by ischemic reperfusion led to a decrease in A20 protein, which, in turn, caused the activation of RIPK1 and the occurrence of RDA, leading to leakage of the blood–brain barrier. The findings in this study revealed the role of RIPK1 in vascular endothelial cell death and BBB leakage upon cerebral ischemia reperfusion injury (CIRI), and these findings provide a novel perspective for the treatment of ischemic reperfusion.
Knowledge of Rational Drug Use Among Village Health Volunteers in a Municipal Hospital in Thailand
Authors: Yongpraderm Siranee , Sangkhano Kanruethai , Uitrakul Suriyon
Published: September 2021

Village health volunteers (VHVs) are key factors to improve and maintain health status in the Thai population, especially in rural areas. Knowledge in rational drug use of VHVs is essential to help Thai people use medicines appropriately. Therefore, this study aimed to investigate the literacy of VHVs relating to rational drug use in a municipal hospital, Nakhon Si Thammarat province, Thailand. The literacy score was assessed using the questionnaire that was developed based on the Rational Drug Use Manual by the Ministry of Public Health. This questionnaire consists of 5 aspects, including the understanding of drug labels, advertisement evaluation, drug purchasing and using, understanding the meaning of medical terms, and access to drug information. The results were analyzed and described as frequency and percentage. Of all 139 VHVs who participated in the questionnaires, the average score of rational drug use literacy was 16.51 (SD = 5.79) out of 28 (58.96%), which was defined as poor level. Considering by aspects, it was found that the scores in the drug label literacy and understanding of the medical terms were at good levels. Drug purchasing and using aspect was at a moderate level. The advertisement assessment aspect was at a poor level. In conclusion, the results in this study indicated that VHVs in a municipal hospital, Nakhon Si Thammarat province, Thailand, should strengthen the knowledge relating to evaluation of advertising media and purchasing and using of drugs.
Intraocular Schwannoma: Case Series of 28 Patients and Literature Review
Authors: Liu Yue-Ming , Dong Li , Xu Xiao-Lin , Li He-Yan , Yang Qiong , Zhang Rui-Heng , Wei Wen-Bin
Published: September 2021

Background: Intraocular schwannoma is a rare intraocular tumor, which is often misdiagnosed. We aimed to analyze the demographics and clinical characteristics of patients with intraocular schwannoma.Methods: Retrospective case series were collected from May 2005 to July 2021 in Beijing Tongren Hospital. Then a literature review was also performed.Results: A total of 28 patients were diagnosed with intraocular schwannoma histopathologically. The median age (range) of the included patients was 39 (12-64) years old, among whom half subjects were female. The most common symptom was visual loss (75.0%), followed by visual field loss (10.7%). Intraocular schwannoma presented as nonpigmented mass, which occurred mainly in ciliary body (42.9%), followed by choroid (32.1%) and ciliochoroid (25.0%).16 patients (57.1%) were clinically misdiagnosed as uveal melanoma. Tumor excision was performed for all patients and increased light transmission was detected in half cases. In the consecutive follow-up (median: 6.0 years, range: 0.5-16.0 years), no recurrence or metastasis case was detected.Conclusions: Intraocular schwannoma is a rare benign intraocular tumor. It usually presents as nonpigmented mass, which is easily misdiagnosed as nonpigmented uveal melanoma.
Notch1 Signaling Modulates Hypoxia-induced Multidrug Resistance of Human Laryngeal Cancer Cells
Authors: Li Dawei , Xu Dan , Chen Penghui , Xie Jin
Published: September 2021

Background: Laryngeal carcinoma is one of the common malignant tumors of the head and neck. Multidrug resistance (MDR) remains a critical problem in the chemotherapy for patients with laryngeal cancer. This study aims to clarify the role and mechanisms of Notch1 signaling on MDR induced by hypoxia in laryngeal cancer cells.Methods and Results: Laryngeal carcinoma cells were cultured under normoxia or hypoxia. Notch1 expression was inhibited by small interfering RNA (siRNA). The expression of Notch1, Hes1, Hey1, MDR1 and survivin mRNA was determined by Real-time PCR. The expression of Notch1, Notch1 intracellular domain (N1ICD), MDR1/P-gp and survivin protein was detected by Western blot. Current research showed that hypoxia could upregulate Notch1 expression and the activity of Notch1 signaling. Furthermore, suppression of Notch1 expression could effectively down-regulate the activity of Notch1 signaling and the expression of MDR and survivin genes in laryngeal cancer cells under hypoxia (P<0.05). Cell Counting Kit-8 (CCK-8) assay confirmed that the sensitivity of hypoxic laryngeal cancer cells to a variety of drugs could be up-regulated by suppressing Notch1 expression (P<0.05). Additionally, flow cytometry (FCM) showed that suppression of Notch1 expression significantly increased cisplatin-induced apoptosis and intracellular Rh123 (Rh123) accumulation in hypoxic laryngeal carcinoma cells (P<0.05). Conclusions: Notch1 signalling could be regarded as a pivotal regulator for mediating hypoxia-induced MDR in laryngeal cancer cells by regulating survivin-mediated apoptosis resistance and MDR1/P-gp-mediated drug transport.
Coupling photocatalytic water oxidation with organic reduction: strategy for using water to reduce organic molecules
Authors: Tian Xinzhe , Guo Yinggang , Liu Wenbo , Zheng Yi , Ren Yun-Lai , An Wankai , Niu Caoyuan , Wang Jianji
Published: September 2021

The utilization of readily available and non-toxic water by photocatalytic water splitting is highly attractive in green chemistry. Herein we report that light-induced oxidative half-reaction of water splitting is effectively coupled with reduction of organic compounds, which opens up, for the first time, an avenue to use water as an electron donor to enable reductive transformations of organic substances. The used photocatalyst (Pd/g-C3N4*) was synthetized by a novel method where Pd/g-C3N4 was irradiated by light in the presence of Na2CO3 and H2O. The present strategy allowed a series of aryl bromides to undergo the reductive coupling to provide biaryl products in low to high yields. Preliminary mechanistic investigation suggests that the reaction proceeds through the single electron transfer from Pd to aryl bromides. This work will guide chemists to use water as a reducing agent to develop green procedures for various organic reactions.
The Influence of Compost Amendments on Bioaccumulation of Potentially Toxic Elements by Pea Plant Cultivated in Mine Degraded Soils
Authors: Irfan Muhammad , Shah Muhammad Azhar , Alam Mehboob , Khan Anwarzeb , Khan Muhammad Amjad , Rahman Saifur , Alsaiari Mabkhoot A , Jalalah Mohammed Saeed , Khan Mohammad Kamal Asif , Ghanim Abdulnour Ali Jazem
Published: September 2021

Potential toxic metals (PTEs) accumulation in soil and water is one of the major sources of food crop contamination. PTEs remediation from soil can be enhanced by addition of organic matter to the growing media. An experiment was carried out to investigate the effect of different organic amendments on the accumulation of PTEs in pea plant grown on mine degraded soils. Mining soils from chromite mine (CM), soap stone mine (SSM), manganese mine (MM) and quartz mine (QM) were mixed with vermicompost (VC), leaf mould (LC) and spent mushroom compost (SMC) along with garden soil at 1:1:1 ratio. Various growth and yield related attributes of pea plant as well as PTEs concentrations in soil and plants were studied. The highest Cd (2.62 mg kg−1) and Cr (13.6 mg kg−1) concentration was reported in CM soil, while Pb (23.3 mg kg−1) and Mn (59.2 mg kg−1) concentration in SSM and MM soil, respectively. Mining soils significantly reduced the plant growth and yield, while organic amendments reduced the PTEs availability and increased pea plant growth. Comparing the various organic fertilizers used, it was observed that VC efficiently reduced Cd, Cr, Pb and Mn uptake by pea plant, subsequently, improved pea plant growth. In order to assess the effects of various amendments on PTEs health risk reduction various risk indices including, plant trafser factor, average daily intake, health risk, target hazard quotient and target cancer risk were also calculated and the results revealed that application of compost particularly VC significantly reduced the dietary intake and health risks of PTEs.
Lymph-Node-Sampler-Based Nucleic Acid Detection Helps to Diagnose and Control African Swine Fever in Pig Production
Authors: Li Xiaowen , Li Yang , Fan Mingyu , Fan Shiran , Gao Wenchao , Yuan Peng , Ren Jing , Li Jingtao , Yu Jincheng , Wu Weisheng , Li Junxian , Yu Qiannan , Shao Zhenwen , Yan Zhichun
Published: September 2021

Background: African swine fever (ASF) is a highly contagious hemorrhagic and transboundary animal disease. It has rapidly spread to many regions of the world and is responsible for serious production and economic losses. However, clinical diagnosis is impractical for the similar classic symptoms of ASF and several other normal diseases. How to make a definite diagnosis is a top priority. Results: In the present study, lymph node samples were collected by the patented “lymph node sampler”, which makes the sampling safer, more efficient and minimally invasive. The ASF virus (ASFV) contents of lymph node sample as well as serum, oral fluid, nasal and rectal swab samples from pig production line were detected by real-time PCR. The big data results demonstrated that the lymph node samples contained more stable and strongly positive ASFV nucleic acid than the porcine exudate and serum samples. Taking the lymph node sample is one of the assistant ways in diagnosing pigs suspected of having ASF. We supervised twenty farms that realized the accurate diagnosis and eliminating of the risk in the shortest time period by using lymph node sampler. Conclusions: Our findings suggest that the lymph node sample is an ideal tissue for diagnosing ASFV infection. The lymph node sampler is a convenient tool for lymph node sampling for practitioners.
A Pan-cancer Analysis of the Prognostic and Immunological Role of PPP1R14A
Authors: Lu JiaJie , Huang Rihong , Wang Haojian , Peng Yuecheng , Fan Yongyang , Feng Zejia , Zeng Zhaorong , Ji Yunxiang , Wang Yezhong , Wang Zhaotao
Published: September 2021

BackgroundDespite emerging evidence revealed the remarkable roles of Protein Phosphatase 1 Regulatory Inhibitor Subunit 14A (PPP1R14A) in cancer tumorigenesis and progression, no pan-cancer analysis is available. Our research, for the first time, comprehensively investigated the potential carcinogenic mechanism of PPP1R14A across 33 tumors using bioinformatic techniques. MethodsTCGA datasets and the CPTAC datasets embedded in UALCAN were first applied to study the differential expression of PPP1R14A in various cancer types at the transcription and protein levels, respectively. Besides, we also conducted relevant prognostic survival analysis and used the GEPIA2 database to explore the association between PPP1R14A expression and pathological stages. In addition, cBioPortal and UALCAN databases were employed to analyze the genetic alterations and post-transcriptional phosphorylation of PPP1R14A. Then based on TCGA, we analyzed the relationship between PPP1R14A and immune infiltration, the correlation with tumor mutational burden (TMB), microsatellite instability (MSI) and immune checkpoint molecules (ICMs), and whether it is expected to be a predictive indicator in cancer patients, which was achieved by receiver operating characteristic (ROC) curve. Finally, STRING, GEPIE2 and TIMER2.0 databased were used to explore the potential mechanism of PPP1R14A in cancer and find molecules that have potential close interactions with PPP1R14A.ResultsPPP1R14A is down-expressed in major malignancies and there is a significant correlation between the PPP1R14A expression and the prognosis of patients. Pan-cancer survival analysis indicated that the high expression of PPP1R14A in most cases was associated with poor overall survival (OS), disease-specific survival (DSS), and progress-free interval (PFI) across patients with various malignant tumors, containing adrenocortical carcinoma (ACC), bladder urothelial carcinoma (BLCA). The results of ROC analysis subsequently exhibited that the molecule has a high reference significance in diagnosing a variety of cancers. Besides, we detected that the frequency of PPP1R14A genetic changes including genetic mutations and copy number alterations (CNAs) in uterine carcinosarcoma reached 16.07%, and these alterations brought misfortune to the survival and prognosis of cancer patients. In addition, the methylation within the promoter region of PPP1R14A DNA was enhanced in a majority of cancers. Downregulated phosphorylation levels of phosphorylation sites including S26, T38, etc. in most cases took place in several tumors, such as breast cancer, colon cancer, etc. PPP1R14A remarkably correlated with the levels of infiltrating cells and immune checkpoint genes. ConclusionsOur research summarized and analyzed the carcinogenic effect of PPP1R14A in different tumors comprehensively and provided a theoretical basis for promising therapeutic and immunotherapy strategies.
BRAF p.V600E Mutation as Acquired Resistance Mechanism of Lorlatinib in a ROS1 Rearrangement Lung Adenocarcinoma Patient with Primary Ceritinib Resistance
Authors: Liu Zhulin , Han Zhaojie , Nie Naifu , Feng Mingxia , Li Li , He Yong
Published: September 2021

Both crizotinib and ceritinib are recommended as first-line theray for NSCLC with ROS1 rearrangements, with the latter having stronger infiltration ability across blood-brain barrier. Here we report for the first time that a brain metastatic adenocarcinoma patient with CD74-ROS1 rearrangement was sensitive to crizotinib but resistant to ceritinib. Intracranial progression happened after 7 months of crizotinib, and sencond-line lorlatinib resulted in partial response and a PFS of 8 months. Upon lorlatinib resistance, repeated NGS detection of ctDNA from peripheral blood showed BRAF p.V600E, CD74-ROS1 and ROS1 pG2032R. Then, Trametinib, dabrafenib, and cabozantinib was administered to the patient. However, disease progressed very quickly and the patient passed away only one month later, with a overall survival of months. The last ctDNA test, one week before death of the patient, found that BRAF p.V600E disappeared, leaving only CD74-ROS1and ROS1 pG2032R,with a very high frequency. To our knowledge, this is the first case report of a ROS-1 rearrangement lung cancer patient that is sensitive to crizotinib but resistant to ceritinib, and BRAF p.V600E as resistant mechanism for lorlatinib.
Evaluation of the Dynamic Behavior, Elastic Properties, and in Vitro Bioactivity of Some Borophosphosilicate Glasses for Orthopedic Applications
Authors: Abushanab Waheed S. , Moustafa Essam B. , Youness Rasha
Published: September 2021

The present work employed the finite element model (FEM) to predict the influence of successive increases in borate (B2O3) contents, from 0 to 25 mol%, on both the mechanical properties and dynamic behavior. By feeding the isotropic elasticity characteristics of the phosphosilicate glass to the model, such as Young's modulus, density, and maximum compressive stress of the produced glass samples to fit the aim of their clinical use. The effect of successive addition of B2O3 on the in vitro bioactivity of the examined glasses in addition to examined after being dipped in simulated body fluid (SBF) at different times. Moreover, tracking the formation of hydroxyapatite (HA)-like layers on their surfaces using X-ray diffraction technique (XRD) technique and scanning electron microscopy (SEM). The results obtained indicated that increasing B2O3 content to 25% was responsible for improving the deflect resistance by 39%. On the other hand, neither shear stress nor principles stress was affected by this increase in B2O3 content. Moreover, the gradual increases in B2O3 contents were very helpful in improving the bioactivity of the samples. From these promising results, the prepared glasses can be successfully used in bone replacement applications.
Safety and Feasibility of Intravascular Ultrasound-Guided Robotic
Authors: Kimura Takumi , Koeda Yorihiko , Ishida Masaru , Yamaya Shohei , Kikuchi Sayaka , Tsuji Keiko , Ishisone Takenori , Goto Iwao , Itoh Tomonori , Morino Yoshihiro
Published: September 2021

PurposePrevious studies have demonstrated the benefit of intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) for preventing longitudinal geographic miss (LGM). However, it is yet unclear whether IVUS guidance is useful for robotic PCI (R-PCI). This retrospective observational study sought to compare expected stent landing positions between IVUS and angiography.MethodsA total of 58 consecutive patients with stable angina who underwent IVUS-guided R-PCI was enrolled. The stent landing position was angiographically marked using a balloon marker before stenting followed by measurements of the expected stent length using balloon pullback. Subsequently, pre-stenting IVUS was performed to determine stent landing. All pre-PCI IVUS images were assessed for lesion length and percent plaque volume (%PV) using both IVUS and angiographic marking. LGM was defined as a residual %PV > 50% at either the distal or proximal stent edge, any stent edge dissection, and/or additional stent deployment immediately after stenting. Major adverse cardiac events were assessed at the 6-month follow-up.ResultsThe included patients, 41 of whom were male, had an average age of 67.1 ± 10.1 years. IVUS guidance had significantly longer lesion lengths compared to angiographic marking. Based on IVUS-guided stent deployment, 9 cases exhibited LGM immediately after stenting. IVUS-marked landing points had a significantly smaller %PV and significantly larger LA compared to those for angiography. No adverse cardiac events were noted during the 6-month follow-up.ConclusionIVUS-guided R-PCI was safe and may be better at preventing LGM compared to angiography-guided R-PCI.
Exploring Efficiency of Biochar in Enhancing Water Retention in Soils with Varying Grain Size Distributions using ANN Technique
Authors: Garg Ankit , Wani Insha , Zhu Honghu , Kushvaha Vinod
Published: September 2021

Recently, incentives have been provided in many countries, including Canada and Denmark, to produce biochar for construction usage. This is done because biochar is carbon negative and can help achieve the emission reduction goal of 2030. This technical note aims to analyze the efficiency of biochar in soils with varying grain size distribution for enhancing water retention capacity (WRC). The combinations of biochar content and grain size distributions corresponding to the maximum and minimum efficiency were explored. Artificial Neural Network (ANN) based model for predicting Soil Water Characteristic Curve (SWCC) as a function of soil suction and grain size distribution was developed. A new factor (the ratio of fine (silt + clay) and coarse (sand) content) was proposed for the interpretation of the efficiency of biochar in soils. The newly developed model is able to predict SWCC reasonably well. Biochar amendment is found to influence both dry and wet sides of soils with a clay content lower than threshold content (6–8%). Beyond threshold content, the influence of biochar appears to reduce. However, in the case of high sand content soils (90%), the NWC value on the drier side is generally higher as compared to soils with lower sand content. Based on sensitivity analysis, it was found that the ratio of fine to sand content is the most influential, while biochar content is the least influential.
The efficacy of Hybrid Hyrax-Mentoplate combination in early Class III treatment: a novel approach and pilot study
Authors: Katyal Vandana , Wilmes Benedict , Nienkemper Manuel , Darendeliler M. Ali , Sampson Wayne , Drescher Dieter
Published: September 2021

Introduction

The aim of the present study was to assess the skeletal, dental and soft tissue effects of a specific treatment protocol in consecutively treated patients who presented with a Class III malocclusion. Treatment involved the use of a Hybrid Hyrax (HH) in the maxilla, a Mentoplate in the mandible and the application of continuous intra-oral Class III elastics.

Method

The treated group was comprised of seven males and seven females (mean pretreatment age 10.4 ± 1.7 yr, range 7.8 – 12.9 yr). Treatment changes were analysed on lateral cephalograms taken 6–12 months prior to commencing treatment (T1) and at the finish of the orthopaedic phase (T2). Where a normality assumption was met, a parametric paired-sample t-test was used to assess the change differences at T1 and T2. For non-normal data, a non-parametric Wilcoxon sign rank test for related samples was used to assess T1 and T2 differences. The level of statistical significance was set at p < 0.05 (2-tailed).

Results

The average sagittal changes showed an improved SNA angle of 2.1 ± 2° (p = 0.002), an ANB angle of 1.9 ± 1.8° (p = 0.002), a Wits improvement of 3.4 ± 2.7 mm (p < 0.001) and an overjet reduction of 2.0 ± 2.2 mm (p = 0.005). There were no statistically significant correlations found between the age at T1, age at treatment start and age at T2 and the changes identified in the cephalometric variables (T2-T1).

Conclusion

The HH-Mentoplate Class III treatment protocol induced a mean Wits improvement of 3.4 mm in the maxillary and mandibular sagittal base relationship at the functional occlusal level. This was primarily achieved by sagittal maxillary skeletal protraction with negligible effects on the mandible, facial vertical dimension and the incisor angulations. A controlled clinical study with larger sample sizes and longer follow-up times is needed.
The effect of smiling on facial asymmetry in adults: a 3D evaluation
Authors: Darby Laura J. , Millett Declan T. , Kelly Niamh , McIntyre Grant T. , Cronin Michael S.
Published: September 2021

Background/aims

Mild resting facial asymmetry exists in clinically symmetrical faces, but the effect of smiling on the magnitude of overall facial asymmetry in adults has not been assessed. The aim of the present study was to use stereophotogrammetry to quantify the effect of smiling on overall facial asymmetry in Caucasian adults who presented with Class I incisor relationships and no history of orthodontic treatment.

Methods

Twenty male and 20 female Caucasians aged 18–30 years with no history of orthodontic treatment, a clinically symmetrical face and a Class I incisor relationship had 3D stereophotogrammetric images captured at rest and on natural and maximal smile (T1). The images were repeated 2–4 weeks later (T2) to assess expression reproducibility. Overall facial asymmetry scores were produced from 27 landmarks using partial Ordinary Procrustes Analysis (OPA) and assessed by an Analysis of Covariance (ANCOVA) model. A random sample of the images was re-examined two months later to calculate intraobserver landmark reproducibility.

Results

Mean landmark error was low (0.41 ± 0.07 mm). Mean overall facial asymmetry scores were not significantly gender different (p = 0.5300); therefore, the male and female data were pooled. Mean overall facial asymmetry scores for maximal (0.91 ± 0.16) and natural smile (0.88 ± 0.18) were higher than at rest (0.80 ± 0.17) (p < 0.0001) and were reproducible across (T1–T2) sessions (p = 0.3204).

Conclusions/implications

Overall 3D facial asymmetry scores for the sampled Caucasian adults with clinically symmetrical faces increased in magnitude from rest to natural and to maximal smile. Clinicians should assess overall facial asymmetry at rest and on natural and maximal smile at baseline, during treatment and as part of a core outcome assessment, particularly for cases with unilateral posterior crossbite, unilateral cleft lip and palate or skeletal asymmetry.
PERFORMANCE EVOLUTION OF JAMMU AND KASHMIR STATE FINANCIAL CORPORATION
Authors:   Research Scholar, School of Commerce, Devi Ahilya University, Indore, Madhya Pradesh, India, Gul Maryama , Sanse P.K. ,   Professor of Commerce B.L.P. Govt. P.G College Mhow (M.P)
Published: September 2021

The objective of this study was to assess the performance of JK SFC. The establishment of State financial Corporations was, one of the steps taken, at the official level to promote the growth of small and mediumscale industries. The Jammu and Kashmir State Financial Corporation is a statutory Corporation established under SFCs Act 1951(Central Act 63 of 1951) which is facing heavy losses due to no source of funds and no recovery of loans. In the present study performance of JKSFC was analyzed with different tools like trend analysis and ratio analysis and average growth rate. The results of the study show that performance of JKSFC is declining during the research period due tofacing problems of liquidity & solvency.
AN INTELLIGENT CBMIR SYSTEM FOR DETECTION AND LOCALIZATION OF LUNG DISEASES
Authors:   PhD. Student, Computer and system Department, Electronics Research Institute, Cairo, Egypt., I. Yahia Nora , I. Al-Dosouki Ayman ,   Professor, Computer and system Department, Electronics Research Institute, Cairo, Egypt., A. Mokhtar Sahar ,   Professor Assistance, Computer and system Department, Electronics Research Institute, Cairo, Egypt., M. Harb Hany ,   Professor, Computer and system Engineering Department, Faculty of Engineering, Al-Azhar University, Cairo, Egypt.
Published: September 2021

The diagnosis of lung diseases is a complicated and time-consuming task for radiologists. Often radiologists struggle with accurately diagnosing lung diseases, They use Commonly CT imaging signs (CISs) which common appear in CT lung nodules in the diagnosis of lung diseases. Computer-aided diagnosis systems (CAD) can automatically diagnose and detect these signs by analyzing CT scans, which will reduce radiologists workload. The diagnosis and recognition efficiency and accuracy can be improved by using content-based medical image retrieval (CBMIR). This paper proposes a new intelligent CBMIR method to retrieve CISs helping in diagnosing and recognize lung diseases by using deep Convolutional Neural Network (CNN). Fine-tuned YOLOv4 (You Only Look Once) object detector model are proposed to fast detect and efficiently localize signs in real-time. The proposed CBMIR system can be applied as a useful and accurate medical instrument for diagnostics. The experimental results show an average detection accuracy of CT signs lung diseases as high as 92% and a mean average precision (MAP) of 0.92 is achieved using the proposed technique. Also, it takes only 0.1 milliseconds for the retrieval process. The proposed system presents high improvement as compared to the other system. It achieved better precision of retrieval results and the fastest run of the retrieval time.
APPLICATION OF THE GUIDE (GTR) TO PLATFORM FLOORS FROM THE TRARZA AND INCHIRI-MAURITANIA REGION MBLAL-LAHOUVICH AXIS AND AKJOUJT-TASIASIT AXIS
Authors:   Research Scholar, Polytechnic School of Thies, Senegal., Mohameden Babiya Tourad , Sow Djibril ,   Research Teacher, University Institute of Technology of Iba Der Thiam University in Thies, Senegal., Samba Toure Ahmadou ,   Research Scholar, University Institute of Technology of Iba Der Thiam University in Thies, Senegal., Diop Mor ,   Research Scholar, University Institute of Technology of Iba Der Thiam University in Thies, Senegal.
Published: September 2021

In the search for an adequate technical document in the field of road earthworks, and in view of the unavailability of national standards in Mauritania which may be the origin of these documents, this article essentially aims to propose methods of execution of the upper platform. Earthworks and subgrade. As a result, a study was made on platform soils in two regions in Mauritania, one is located in the south-west of the country (Trarza) and the other is in the west (Inchiri). Two roads were chosen, one 3.7km long (Mblal-Lahouvich), and the other 5km (Akjoujt-Tasaisit).
A CLINICAL SUCCESS IN THE MANAGEMENT OF KOTHA (DIGITAL GANGRENE) BY LEECH THERAPYANDPANCHTIKTAGHRITAGUGGULU - A SINGLE CASE STUDY
Authors:   Assistant Professor, Department of Shalya Tantra R.K. University Ayurvedic College & Hospital, Kasturbadham, Rajkot., Bhalara Bharat , Patel Joyal ,   R.M.O. & I/C Assistant Professor, Department of Shalyatantra, ITRA, Jamnagar, Gujrat.
Published: September 2021

Gangrene is a type of tissue death caused by lack of blood supply. Symptoms may include a change in skin colour red or black, numbness, swelling, pain, ulceration and detachment of local skin. The feet and hands are most commonly affected. This condition may arise because of an injury, infection or other health conditions, majorly diabetes. Gangrene and its associated amputations are clinically challenging, but Ayurveda offers therapy options. In Ayurveda, gangrene can be considered as Kotha under DushtaVrana due to Margavarana and Dhatu Kshaya. This case study aims to investigate whether Ayurvedic intervention can manage Kotha (gangrene) without amputation of the gangrenous part. Here a case report disscused diagnosed with kotha(Dry Gangrene) treated with Ayurvedmanagenment,Panchtiktaghritagugguluoral and Jalaukavacharana (leech therapy), whichwere found very effective and safe in a patient of dry gangrene.
E-LEARNING IN THE BANKING SECTORCASE STUDY OF THE NATIONAL BANK OF GREECE
Authors:   Adjunct Academic Staff, University of West Attica, Greece, School of Administrative, Economics and Social Sciences, Department of Business Administration, University, School of Humanities., Xanthopoulou Panagiota , Athanasopoulos Dimitris ,   BSc in Management, University of Queen Margaret, Scotland.
Published: September 2021

This research deals with the issue of distance education in the human resources of banks and specifically of the National Bank of Greece. The purpose of the research was to investigate how distance education affects the human resources of banks in developing their management skills. The research methodology followed was quantitative, while the research tool used was the online questionnaire. The survey sample consisted of 82 people working in the banking sector and their selection was made according to convenient sampling.The results showed that distance education works beneficially for the in-house training of employees in the banking sector. In particular, e-learning programs have been found to contribute to the development of knowledge, work productivity, the acquisition of new skills and the enrichment of existing skills held by employees in the banking sector. It was also clear that the impact of distance education on improving employees skills was multifaceted. Participants were positive about the experience they gained from distance learning programs and want to increase as they state that their benefits vary.The present research is one of the first attempts that aim to record the aspects of e-learning implementation in the banking sector.
MASCULINITIES AND THE CHALLENGE FOR WORKING WITH MEN IN THE UNIVERSITY CONTEXT
Authors:   Professor and researcher of the Faculty of Humanities of the Autonomous University of Campeche., A. Sosa Zumarraga Mtro. Martin , Zurita Moo Br. Roman ,   Student and scholar researcher, Faculty of Humanities of the Autonomous University of Campeche., Mendoza Balan Br. Abril Guadalupe ,   Student and scholar researcher, Faculty of Humanities of the Autonomous University of Campeche.
Published: September 2021

The old hegemonic practice of masculinity is far away from disappearing in many of the region of our country and in frequently encountered family, political or social contexts. Investigation and actions are always aimed at preventing violence and tirelessly promoting policies for the equality of women in places that normally did not occupy and that it is difficult for them to give in to the old patriarchal system. The objective of this case study, is to reflectively analyze educational and social scenarios, to determine the strategies that are had for the denaturalization of the patriarchal organization and the significant change in the matter of work with men from full involvement or integration to a change in sexist practice and beliefs that is reproduced on a daily basis. It is a difficult to think that generations that lived under this type of upbringing or privilege could give way and establish egalitarian ties but that it may be possible to rethink the gender relations they live and the aspects they have had throughout their lives and the importance of building egalitarian relationships.