bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of pharmacist-based medication management for children with medical complexity
Authors: Pal Dr. Tarun , Chandrakar Kunal
Published: February 2025

Coordinating care for children and youngsters with specialized health care requirements and Medical Complexity (MC), particularly Medication Management (MM), poses significant challenges for providers, caregivers, and children. This research outlines the creation of a clinical pharmacotherapy performed in a pediatric long-term Healthcare Capacity (HCC), the implementation of standard procedures for Comprehensive Medicine Management (CMM), and the formation of a Cooperative Practice Arrangement (CPA) to direct the administration of drugs. A prospective case study includes 100 patients identified as MC in this HCC quality enhancement initiative during an 8-month duration.
Medical Pharmacists (MPs) detected, averted, or resolved 1400 treatment problems, averaging 12 treatments per participant. The patients had an average of 9.8 complex chronic medical issues and a median duration of stay of 78 years. The mean number of medications per patient decreased from 25 to 22. A pharmacoeconomic evaluation of 245 therapies indicated an average direct cost reduction of $45k ($450 per patient per month) and a monthly cost prevention of $49k ($490 per patient per month). Twenty-eight emergency department admissions and sixty-one clinic and emergency room visits were averted. Hospital readmissions decreased by 45%. MPs’ suggestions achieved a 95% acceptance rate. Using a CPA to perform CMM in MC diminished pharmaceutical burden, addressed and averted problems, lowered healthcare-related expenses, decreased hospitalizations, and was effectively embraced and cooperatively executed with HCC physicians
Enhancing adherence to asthma treatment control in children and adolescents
Authors: Anand Das Vaishnav Venu , Patel Ritesh
Published: February 2025

To evaluate therapeutic alternatives for the stepwise treatment of asthma, including the unique requirements of this population, including the potential impacts of asthma and its therapies on growth and mental health, and caregiver participation. The study searched PubMed to discover pertinent papers, then reviewed the resulting articles, asthma management recommendations for kids, and documents from personal archives. Recent worldwide and US recommendations advocate a stepwise approach to asthma treatment for kids akin to that for people. Therapy is adjusted upward or downward, momentarily or long-term, depending on the reaction. Inhaled steroids are the preferred treatment for chronic childhood asthma, and any possible slight effects on growth are deemed negligible in comparison to their advantages. Choices for controller medication for individuals under 18 are restricted, particularly for International Initiative for Asthma Stages 2-5. Tiotropium is approved for use in the United States and Europe to treat individuals aged 6 years and older. Gradually reducing therapy, although advised yet seldom implemented, might sustain symptom management and mitigate unwanted effects while significantly lowering expenses. Patient awareness and enhanced monitoring are crucial for self-management and optimal outcomes. There is a necessity to establish specific treatment objectives for kids with asthma through step-up and step-down methodologies to optimize therapeutic advantages and mitigate possible harmful effects.
Healthcare workforce well-being and its effect on patient care quality in the post-pandemic era
Authors: Pandey Rashmi , Nirmal Chandu Himanshu
Published: February 2025

The well-being of healthcare workers plays a pivotal role in maintaining the quality of patient care, particularly in the post-pandemic era where healthcare systems are under heightened pressure. This study investigates the impact of healthcare workforce well-being on the quality of patient care, focusing on the challenges faced by healthcare professionals following the COVID-19 pandemic. The study examines various factors affecting the well-being of healthcare workers, including mental health, physical health, job satisfaction, work-life balance, and organizational support. A survey was conducted among healthcare workers, and data on their well-being and perceptions of patient care quality were analyzed. The findings reveal a significant correlation between healthcare workforce well-being and the perceived quality of patient care, with stressed, fatigued, or emotionally exhausted workers reporting lower levels of patient satisfaction and care quality. Moreover, institutional support, including mental health resources, adequate staffing, and work-life balance initiatives, was found to mitigate negative effects. The study emphasizes the importance of addressing healthcare worker well-being through systemic interventions to ensure high-quality patient care and improve healthcare outcomes in the post-pandemic era.
Healthcare innovations from marine biodiversity: from drug discovery to disease prevention
Authors: Kumar Jaiswal Vinay , Srinivasa Rao Varri
Published: February 2025

Marine biodiversity has emerged as a rich resource for innovative solutions in healthcare, offering promising avenues for drug discovery and disease prevention. This paper explores how marine organisms, with their unique bioactive compounds and adaptations, contribute to the development of novel therapeutics and preventive strategies for various diseases. From anticancer agents to antimicrobial compounds, marine biodiversity is proving to be a valuable asset in addressing unmet medical needs. Additionally, advancements in marine biotechnology are paving the way for sustainable and eco-friendly approaches to healthcare innovations. This study reviews recent research and highlights the potential of marine-derived products in transforming healthcare practices. The exploration of marine biodiversity not only expands the pharmaceutical toolkit available for healthcare but also addresses the urgent need for novel solutions to combat emerging health threats, such as antimicrobial resistance and novel viral outbreaks. This paper underscores the immense potential of marine-derived compounds in fostering a new era of innovative, environmentally-conscious, and effective healthcare solutions.
An Intelligent Diabetic Retinopathy Forecasting System using Modified Deep Neural Network
Authors: Raj Anamika , Mohamad Noor Noor Maizura , Mohemad Rosmayati , Azliza Che Mat Noor , Hussain Shahid , Hussain Shahid
Published: February 2025

Diabetic Retinopathy (DR) is a severe complication of diabetes that can lead to vision impairment and blindness if not detected and treated early. In this research, we propose an advanced forecasting system leveraging a Modified Deep Neural Network (DNN) to enhance the accuracy and efficiency of DR diagnosis. The proposed system integrates a deep learning framework with modifications tailored to the unique characteristics of retinal images affected by diabetes. We introduce specialized features extraction techniques and optimize the network architecture to accommodate the intricacies of diabetic retinal pathology. A comprehensive dataset comprising diverse retinal images is utilized for training and validating the modified DNN model. The experimental results demonstrate superior forecasting accuracy compared to existing methods, highlighting the effectiveness of the proposed approach in early detection and prognosis of diabetic retinopathy. This intelligent forecasting system holds significant promise for improving the clinical management of diabetic patients by facilitating timely intervention and reducing the risk of irreversible visual impairment.
Signal processing techniques to monitor and predict medication response
Authors: Singh Chiranjeev , Syed Sabir Ali Syed Sajid Ali
Published: February 2025

It is noteworthy that biomedical indicators provide important information about how biological systems behave. Physiological and clinical data are improved when these signals are handled properly. Modern physiological frameworks and idiosyncrasies are investigated both subjectively and quantitatively using sophisticated signal processing and example acknowledgment processes. Even if a clinical professional's interpretation and analysis of a sign is emotional in nature, it reflects the depth of their expertise and experience. When done with the right justification, PC analysis of biological indicators may contribute objective solidarity to the master's comprehension. Furthermore, it provides more advanced diagnosis and online monitoring of individuals who are essentially ill. Also, it offers better diagnostics and online patient checking for patients in horrible shape. In the field of clinical imaging, attractive reverberation imaging, or MR imaging, is a notable and state of the art innovation that offers accuracy and reliable information. Since attractive reverberation imaging (X-ray) is harmless and delivers no ionizing radiation, it is inclined toward above other imaging strategies for clinical imaging. In MR picture examination, division is a urgent step. The method of giving every pixel in an image a name so pixels with a similar mark have specific properties is known as picture division. A computerized picture is partitioned into various segments, each with similar pixels. The fundamental goal of picture division, which enables handling for a variety of purposes, is to deconstruct and transform an image's representation into a more rational and sensible arrangement.
Antidiabetic Potential of Emodin in Streptozotocin-Induced Type-2 Diabetic Rats Evaluating the security and privacy of pharmacy-based electronic health records
Authors: Gurudiwan Prachi , Kumar Sahu Mahendra
Published: February 2025

The phrase "cloud computing" refers to a new technology that allows users to store data remotely. Data privacy, data sharing, and keyword searching in encrypted data are the main problems with cloud computing that cloud users face. Effective data exchange and privacy protection are lacking in the current cloud platform solutions. Additionally, it is necessary to increase the effectiveness of different techniques with the present technical audits. However, it results in issues with traceability and freshness of data while maintaining privacy. Privacy-Preserving Data Mining (PPDM) is a new field with privacy concerns and a lot of fresh work being done. The Cloud is the most cutting-edge technology available in the digital world for storing enormous amounts of Internet data. One of the real-time outsourcing strategies for storing Internet data on the cloud is cloud computing. The cloud is where a vast amount of Internet data can be gathered. Data access is possible anywhere, at any time, and with minimal effort and unreal resources (e.g., different apps, software systems, hardware systems, and progressive operating environments). The operational settings and applications are modified and redesigned based on the type of data, allowing for the optimal use of the environment and verifying a variable burden. While reliability depends on the service provided by the flexible service level approach, implementation is dependent on the surrounding environment and other pertinent competencies.
Developing a secure and private tele pharmacy platform for remote medication management
Authors: Kumar Mire Sanjay , Kumar Sahu Kishor
Published: February 2025

Implementing the e-healthcare paradigm has gained popularity recently throughout different research communities on a global scale. Through the use of contemporary information and communication technology, the e-healthcare solution sends the pertinent patient data to a distant healthcare facility and the relevant medical specialists. Sensitive data access and transmission methods over unprotected channels, however, are dangerous and provide serious security risks. Protecting patient medical information security from unauthorized access or users is crucial, according to standard agencies. Furthermore, studies have shown that identity theft pertaining to medical conditions is a growing and serious crime. Watermarking, steganography, and cryptography are the three methods used to safeguard medical data. Watermarking is the most widely used and promising of these strategies. Hence, medical image data and their dimensionalities are rapidly expanding. Because of these expansions in medical data, manually managing the file system is becoming increasingly challenging. Therefore, the management of medical data has become a major concern for healthcare practitioners. In the medical field, cloud computing is commonly utilised for storing, computing, and exchanging patient medical records. The hospital merely needs to collect patient information from files and upload the data to the cloud for storage via cloud computing.
Evaluating the effectiveness of tele pharmacy services on patient outcomes
Authors: Saharan Priyanka , Srinivasa Rao Varri
Published: February 2025

Pharmaceutical care has caused pharmacy practice to become more patient-oriented rather than medication product-oriented, with the goal of achieving specific results that enhance patients' quality of life. Pharmacists can play a significant role in providing patients with individualized care and specifically in effectively controlling the rising prevalence of chronic non-communicable diseases (NCDs) since patients contact them more frequently. In India, the lack of professional training and ongoing pharmacy education, clinical knowledge, and clinical skills results in low self-esteem and negatively impacts patient care delivery. Community pharmacists must improve their knowledge by learning new things on a regular basis, honing their abilities, and shifting their focus from only distributing medications to more patient-focused services. The community's adoption of efficient pharmaceutical care procedures is hampered by numerous obstacles, which must be found and removed through methodical investigation. The number of elderly people is growing globally. Geriatric health issues demand particular attention because elderly individuals deal with a variety of issues, such as health, social support, and financial instability. An occurrence or circumstance involving drug therapy that fundamentally or hypothetically impedes the patient's expected health outcomes is referred to as a drug-related problem (DRP). The third or fourth most common cause of death for older adults is DRP. The study's objective was to assess how well a pharmacological care program affected the health outcomes of elderly people. The current investigation was a three-year prospective interventional study that was conducted in three stages: preintervention, intervention, and postintervention. Pre-rounds, ward rounds with physicians, and inpatient case records were used to gather information about the patients' medication therapy.
Assessing the impact of medication adherence on health outcomes in pediatric patients with chronic diseases
Authors: Nanda Naimish , Ali Syed Sabir Ali Syed Sajid
Published: February 2025

Children's prescription non-adherence is a challenging problem for the healthcare system. This problem may be influenced by the child's age, lack of knowledge about the illness or its treatment, culture, family dynamics, financial situation, drug use, and preferences. The most effective practices may focus on well-defined mediations for each patient and their family members. Drug specialists are at the forefront of patient care and can help patients take their drugs more consistently by providing guidance and building a trustworthy relationship with the family. This article discusses frequent adherence issues with children’s chronic diseases and offers some methods to improve adherence. Pharmacotherapy is frequently used over an extended period of time to treat chronic disorders. Approximately 50% of patients do not take their prescriptions as recommended, so even while these drugs are effective at fighting disease, their full advantages are sometimes not realized. Poor drug adherence can be caused by a wide range of factors, including those pertaining to individuals, doctors, and health care systems. The complexity and diversity of drug adherence hurdles necessitate multifaceted approaches to adherence improvement.
The Role of miRNA Let-7a-1 and Let-7f-1 in Regulating Inflammatory and Angiogenic Pathways in Endometriosis
Authors: Saddang Wahyuni , Abdullah Nusratuddin , Hamid Firdaus , Bte Ladju Rusdiana , Idris Irfan , Wahyuni Sitti , Sriwijaya Sriwijaya , Maidarti Mila
Published: February 2025

Background
Endometriosis, a chronic gynecological disorder characterized by the ectopic growth of endometrial tissue, involves complex inflammatory and angiogenic mechanisms. MicroRNAs (miRNAs), particularly Let-7a-1 and Let-7f-1, have been identified as key regulators of these pathways, influencing the progression and symptoms of the disease.  
Objectives
This review aims to explore the roles of miRNA Let-7a-1 and Let-7f-1 in the regulation of inflammatory and angiogenic pathways in endometriosis, highlighting their potential as biomarkers and therapeutic targets.
Materials and Methods
A comprehensive literature search was conducted using databases such as PubMed, Scopus, and Web of Science. Relevant studies published between 2000 and 2024 were included, focusing on the expression, function, and regulatory mechanisms of Let-7a-1 and Let-7f-1 in endometriosis. Key findings were synthesized to provide an updated understanding of their biological and clinical relevance.
Results
Evidence indicates that Let-7a-1 and Let-7f-1 play pivotal roles in modulating pro-inflammatory cytokines, angiogenic factors like VEGF, and cellular proliferation in endometriotic lesions. Dysregulated expression of these miRNAs is associated with enhanced inflammatory responses and aberrant angiogenesis, contributing to the persistence and progression of endometriosis. Furthermore, preclinical studies demonstrate that targeting Let-7 family miRNAs can mitigate these processes, suggesting their potential utility in therapeutic strategies.
Conclusion
Let-7a-1 and Let-7f-1 serve as critical modulators in the inflammatory and angiogenic pathways of endometriosis, offering insights into disease pathophysiology. Their roles as biomarkers and therapeutic targets warrant further investigation, paving the way for novel diagnostic and treatment approaches in endometriosis management.
Esophageal stricture as a complication in post operative neonates with congenital esophageal atresia with tracheoesophageal fistula
Authors: Gupta Tarun , Sweta Soni Edamakanti , Onkareshwar Kavthekar Saiprasad , Pralhad Bharati Hemant , Patil Santosh V. , Jadhav Sudhakar
Published: February 2025

Introduction: Esophageal Atresia (EA) with Tracheoesophageal fistula (TOF) is one of the commonest congenital anomalies encountered in the pediatric surgery with commonest postoperative complication as esophageal stricture (ES) and gastroesophageal reflux disease (GERD). The aim of this study was to identify factors associated with ES formation in EA with TOF during post operative period.
Materials and Methods: This cross-sectional study was carried out in pediatrics surgery department. A total 30 neonates with EA with TOF who were diagnosed clinically and radiologically were included while pure atresia cases were excluded. The distance between upper and lower esophageal pouch was noted with ruler intraoperatively. Post operative soluble contrast dye study was done to detect leaks. If no was leak present then ratio of upper and lower esophageal pouch width (UPW: LPW) was measured. During follow up, ES and GERD were diagnosed clinically and radiologically. The data was analyzed using MS-Excel and SPSS software and p value < 0.5 was taken as significant.
Results: The measurement of gap between upper & lower pouch was < 2cms and >2cms in 12(40%) and 18(60%) patients respectively. The ES was found in 9(30%), GERD in 1(3.3%) and both ES and GERD in 6(20%) patients. The ratio of UPW: LPW found to be more than 1.5, equal to 1.5 and less than 1.5 in 12,2 and 1 patient respectively with ES. Dilatation for ES was required in all those with UPW: LPW >1.5 which was statistically significant. The postoperative UPW:LPW ratio showed statistically significant correlation with the intraoperative gap between upper & lower pouch and anastomosis under tension.
Conclusion: The ES had significant correlation with gap between upper & lower esophageal pouch more than 2 cm and anastomosis under tension. The ratio of UPW: LPW ≥1.5 needed dilatation for ES during follow up.
Social Media Platforms and their Relevance in Providing Psychological Support among Infertility Patients
Authors: Lobo Deepika , Joshi Meenakshi , Sharma Jyotika
Published: February 2025

Infertility is a life-altering condition that often leads to psychological distress, including feelings of isolation, grief, and anxiety. Infertility is defined as the ‘failure to establish a clinical pregnancy after 12 months of regular and unprotected sexual intercourse’, affecting about 12–18% of women aged 18–44 years.(Lotti and Maggi, 2015; Vander Borght and Wyns, 2018).With the rise of social media, online platforms have become essential in providing emotional and psychological support to individuals coping with infertility. This paper explores the role of social media platforms in offering psychological support to infertility patients, focusing on the apps that are most commonly used and valued by individuals going through infertility treatments. The paper examines the features of these platforms, how they contribute to reducing emotional distress, and their potential benefits and limitations.
UPLC Method Development and Validation for Sofosbuvir, Velpatasvir, and Voxilaprevir Determination
Authors: Israel. D Samson , Prasath Aroun , Parthasarathy Kavitha , Surekha M. L. , Kumar Garnipudi Dileep
Published: February 2025

It has been stated that an ideal analytical technique is highly desirable for formulating pharmaceutical prescription. This work describes and validates the new UPLC method for the identification of Sofosbuvir, Velpatasvir, and Voxilaprevir in drug products. Details of developed method was checked for precision, accuracy, linearity, sensitivity and robustness and found it abide ICH guidelines for validation. The chromatographic separation was done on a C18 column and a gradient mobile phase of acetonitrile and buffer at certain conditions. All the analytes were estimated at 260 nm. The selected method displayed a perfect linear response within high concentration levels of the drug more than 0.999 with the merits values for all three drugs. Validation results provided further support to the suitability of the described method in routine quality control analysis where this approach would stabilize pharmaceutical quality assurance in terms of rapidity and cost-effectiveness.
Harnessing Supervised Machine Learning for Early Detection of Oral Cancer: A Step Towards Smarter Healthcare
Authors: Baghel Smita , Shukla Anupam , Tiwari Ritu , Jain Priyank
Published: February 2025

In order to improve patient outcomes in oncology, this study investigates the incorporation of supervised machine learning (ML) approaches to improve oral cancer early detection. Early detection of precancerous and cancerous lesions is crucial since oral squamous cell carcinoma accounts for a sizable percentage of cancers globally. Using clinical data and histopathology pictures, the study assesses many supervised learning models, concentrating on performance parameters including accuracy, sensitivity, specificity, and area under the curve (AUC). The study intends to determine the efficacy of these models in comparison to traditional diagnostic techniques by examining the body of existing literature and applying state-of-the-art machine learning algorithms. According to preliminary research, machine learning technology can greatly increase the precision of oral cancer screenings, which would enhance diagnosis and treatment planning. This study demonstrates how artificial intelligence (AI) is revolutionising healthcare and opening the door to more intelligent and effective diagnostic techniques in the fight against oral cancer.
Pyloric Atresia in a Neonate: Harbinger of clinical suspicion; A Case Report
Authors: Yadav Kamal , Chandra Tudu , Harish , Madhavnarayan Totadri Varsha , Kumar Mohanty Subrat , Kumar Jena Pradeep
Published: February 2025

Pyloric atresia is an extremely rare congenital anomaly that typically presents in the neonatal period with symptoms of non-bilious vomiting, feed intolerance and upper abdominal distension. X ray abdomen and pelvis in a classical case shows a single gas bubble/single large stomach shadow in the abdomen. Differential diagnosis include supraampullary duodenal atresia, antral web and malrotation with midgut volvulus. Due to its rare occurrence, diagnosis requires a high index of suspicion. Isolated Pyloric atresia has a relatively good prognosis whereas Pyloric atresia associated with other congenital conditions such as epidermolysis bullosa (most commonly associated), multiple atresia syndrome and aplasia cutis congenita carries a more dire prognosis. Prompt diagnosis and surgical intervention are critical to prevent severe complications. Here we describe a three-day-old female neonate, who presented to us with history of feed intolerance and non bilious vomiting since birth. Upon evaluation the neonate was suspected to have pyloric atresia,. The patient underwent a pyloroplasty for membranous atresia (Type 1 pyloric atresia) and thereafter had an excellent postoperative recovery period. This Case report illustrates the clinical presentation, diagnostic findings, surgical management and reviews the literature available with respect to pyloric atresia, with the aim of highlighting the importance of early recognition and appropriate surgical treatment of one of the rare types of gastrointestinal atresia.
Liability in Robotic Surgery: Legal Frameworks and Case Studies
Authors: Bagwan M.B. , Joshi Tanya , Atul Goswami Rahul , S. Patil Ravindra , Sharma Vandana , Kiran Wani Lalita
Published: February 2025

Because it promises better results, shorter healing times, and high accuracy, robotic surgery which uses modern technology to help doctors do minimally invasive procedures has become very popular very quickly in the medical world. But using robots in surgery brings up difficult legal questions about who is responsible. The main point of this argument is who is responsible when there are medical mistakes or malpractice. This essay looks into the law aspects of robotic surgery and uses case studies to figure out who is responsible for what: medical schools, doctors, and companies that make robotic systems. By looking at the current state of medical malpractice rules in relation to robotic surgery, it shows that there are problems with how responsibility is assigned. Some of the important things that were talked about were the duty of surgeons, the role of medical institutions in making sure that the right training, maintenance, and system changes happen, and the purpose of companies that make robotic systems. By looking at actual court cases, the paper is able to bring up legal examples and issues that could help guide future hearings on robotic surgery malpractice. The goal is to study how to make better law systems that can keep up with how medical technology changes and protect patients' rights. The study also stresses the need for rules to keep up with changes in technology and for healthcare workers to fully understand their legal duties when it comes to robotic surgery.
Legal Boundaries of Cosmetic and Elective Surgeries
Authors: S. Patil Ravindra , Singh Namrata , Kulkarni Shantanu , Kulkarni Shantanu , S.S. Rahul , Sharma Mahesh
Published: February 2025

The law is paying more and more attention to cosmetic and optional treatments even although they are often viewed as personal choices because of the complex concerns regarding patient authorisation, medical standards, and complications that might arise after surgery. People desire to appear better, hence these procedures have grown really popular. This affects legislators, consumers, and medical professionals greatly. The legal bounds of cosmetic and choice therapies are discussed in this article. It also addresses what medical professionals should do to ensure patients provide their consent, that medical standards are observed, and that abuse never occurs. It also addresses how these operations' guiding rules are evolving with time. New guidelines covering advertising, medical safety, and moral factors influencing choices, for instance, abound. Patients who have issues after treatments or are dissatisfied usually run legal issues. This could result in litigation for negligence or failure to satisfy professional standards. The report also addresses the increase of medical tourism, the role insurance plays in financing private treatments, and the variations in laws among nations. This study aims to provide a whole picture of how the law influences choice operations by means of case law, ethical concerns, and fresh developments in the plastic surgery industry. These findings highlight the need of clearly defining laws to safeguard patient rights and maintain ethical standards in the sector by means of which care standards remain high.
Effect of Integrated Yoga Modules and Satvic Diet on Selected Risk Factors Among Men Cancer Patients
Authors: Duraisami V. , Mohana Krishnan Prof. R.
Published: February 2025

Finding the impact of combined yoga modules and a sattvic diet on specific risk variables in male cancer patients was the aim of the current investigation 40 male cancer patients were divided into two groups for the study: the experimental group and the control group. There were twenty male cancer patients in the experimental group while the control group received no training of any kind; they practiced the Pawanamuktasana series, asana, pranayama, meditation, and relaxation for six weeks. Standardized tests were used to measure the physiological variable (systolic blood pressure) before and after the experiment. After analyzing the data using Analysis of Covariance (ANCOVA), it was determined that among male cancer patients, the Pawanamuktasana series, asana, pranayama, meditation, and relaxation had a significant (P < 0.05) impact on the physiological variable (systolic blood pressure).
The Role of Hemodialysis in Toxicology including neonates: A Systematic Review
Authors: Sivasankar M. , Niranjan Raja I , Parthasarathy S.
Published: February 2025

Background: The management of poisoned patients often is complicated by the need for renal replacement therapies, particularly hemodialysis, to effectively address acute poisonings complicated by renal dysfunction.
Objective: This systematic review synthesizes current literature concerning the use of hemodialysis in toxicology, assessing its effectiveness at toxin clearance and its association with complications.
Methods: A literature search was conducted across major databases, including PubMed, Embase, Cochrane Library, and Web of Science, focusing on articles published from January 2000 to October 2023 that analyze hemodialysis for toxic substance removal. Data extraction prioritized toxin types, patient demographics, hemodialysis specifics, and clinical outcomes.
Results: Hemodialysis is most effective for water-soluble and minimally protein-bound toxins like acetaminophen, lithium, salicylates, methanol, and ethylene glycol. Its effectiveness decreases with highly protein-bound substances, those with a high volume of distribution, and volatile compounds. Inborn errors of metabolism can cause toxic metabolite buildup, affecting neonatal brain development. A study of 20 cases showed that timely hemodialysis improved clinical outcomes in 85% of patients. Common complications include hypotension, infections, and electrolyte imbalances, which require close monitoring and tailored interventions.
Conclusion: Hemodialysis is an important tool in the management of toxicological emergencies. However, the success of hemodialysis is dependent on many factors, including the characteristics of the toxin and the patient's health status. Recent advances in dialysis membranes and Continuous Renal Replacement Therapy have improved its use in such cases. However, there are limitations to its use, and alternative treatment strategies must be considered for some poisonings. This review discusses kidney replacement therapy options, challenges for infants, and the importance of informed catheter use by interventional radiologists.
Road to Success for Women Lawn Tennis in India to International
Authors: Sundar Raj N. , Sherif G F Jamal , Ranjith P. , S Eswaran. , Venkatesh A.
Published: February 2025

Tennis, a racquet sport, has always been one of the few individual sports that Indians have been good at and produced good talent in; also, they have equal contributions with their male players. Tennis player’s careers were not easy in India because of no sponsorship and no encouragement from the local government; it is very difficult to move to the next level of training and traveling to tournaments. Parents were the only source of financial support. Players who want to improve their game develop speed, agility, strength, and coordination through exercise and workouts. However, the great players approach the game, especially by mental attitude. In general, when one plays regularly with different players who are more experienced as participate in higher-level competition, it is easy to improve the skills and to develop the strategies in tennis. A vital component to becoming a professional tennis player is to attack and adapt the same strategies to our strengths. Physical fitness in tennis is very important both to prevent injuries as well as to increase performance. Each player varies in their intensity and duration. The Women's Tennis Association is the main organization that works for the female tennis players, which was founded by Billie Jean King in 1973 on the principle of equal opportunity. Now the WTA is the global leader in women’s tennis professional sports. Players use the service of WTA and gain concrete skills to maximize their performance. Former tennis stars should have access to a variety of initiatives both during and after their careers, such as leadership, career mentoring, networking and legends events, coaching credentials, financial preparation and purchasing, and subsidized university education. It has been demonstrated that these methods for developing female tennis players help them stay at the top of their discipline.
Evaluating The Impact of Structured Training Programs on Stress Reduction Among College Students
Authors: T. Thenmozhi , Kumar M. Senthil , Sanjaykumar Swamynathan
Published: February 2025

Stress has become a significant concern among college students, impacting their academic performance and overall well-being. This research aims to examine the effects of high-intensity and moderate-intensity exercise on stress reduction in college students. Sixty participants were randomly assigned to three groups: Experimental Group I (high-intensity interval training), Experimental Group II (moderate-intensity continuous training), and a control group (no exercise intervention). Stress levels were assessed using a standardized questionnaire before and after a 12-week period. ANOVA was used to analyse the differences in pre- and post-test stress scores, with a significance level set at 0.05. Results revealed substantial reductions in stress for both exercise groups, with mean differences of -4.73 and -4.67 for high- and moderate-intensity groups, respectively (p < 0.0001). The control group showed a minimal reduction of -0.30 (p = 0.0027), which was not significant. These findings suggest that both high- and moderate-intensity physical activities are effective in alleviating stress among college students. The study supports the integration of exercise into campus wellness programs to improve mental health. Further research could investigate the long-term effects of different exercise types and their impact on various stress sources.
Secure SustainNet: A Multi-Objective Framework for Enhancing Security and Sustainability in Data Centers
Authors: Vijayakumar Ramachandran , Duraimutharasan N.
Published: February 2025

This paper introduces the SecureSustainNet Framework, a novel approach designed to enhance security and sustainability within data centers. The framework employs a multi-objective optimization technique that harmonizes security measures with energy efficiency. It includes six core algorithms: Intrusion Detection System with Anomaly Detection, AES-256 Encryption with Optimized Key Management, Role-Based Access Control with Dynamic Policy Adjustment, Dynamic Resource Allocation, Energy Consumption Monitoring and Optimization, and Renewable Energy Integration. The framework was implemented and evaluated using the ns-3 network simulator. The evaluation results demonstrate significant advancements in both security and sustainability. The Intrusion Detection System achieved an Anomaly Detection Rate (ADR) of 98.7%, reflecting high accuracy in threat identification. Encryption overhead was minimized to a 2.5% increase in processing time, showcasing efficient performance. The Role-Based Access Control system attained an effectiveness of 97.4% in preventing unauthorized access. Resource Utilization Efficiency (RUE) reached 85.2%, indicating effective resource management. The framework also achieved a 15.6% reduction in energy consumption and a Power Usage Effectiveness (PUE) of 1.25, signifying improved energy efficiency. These results underline the SecureSustainNet Framework’s effectiveness in integrating robust security measures with advanced sustainability practices, presenting it as a valuable model for optimizing data center operations.
Mass Spectrometry-based Identification of Transferrin Glycosylation Variants for Diagnosis of Congenital Disorders of Glycosylation
Authors: Bindu Allareddy Hima , Ch. Madhurarekha , D. Kalpana , Bhanoori Manjula
Published: February 2025

Congenital disorders of glycosylation (CDG) are a group of metabolic conditions resulting from impaired glycosylation of proteins and/or lipids. Transferrin, a vital glycoprotein present in blood plasma, plays a significant role in our research. We aim to tackle the diagnostic challenges associated with CDG by focusing on transferrin as a key protein for study. Several techniques are used for the quantification of human transferrin, each offering valuable insights into protein levels. While these methods can be highly sensitive, they often fall short in terms of specificity and reproducibility. In contrast, Liquid Chromatography-Mass Spectrometry (LC-MS/MS) offers a more reliable and precise approach, even at low concentrations, making it a superior tool for transferrin analysis in CDG research.
In this study, we present: (i) an efficient and rapid method for purifying transferrin from human serum using rivanol, (ii) a comparative analysis of various techniques for screening CDG samples, including Isoelectric Focusing (IEF), 2D gel electrophoresis, MALDI, and LC-MS/MS, with LC-MS/MS proving to be the most reliable method, and (iii) an LC-MS/MS-based proteomics assay to quantify transferrin isoform levels in human serum, utilizing specific glycosylated peptides. We identified significant biomarker peptides with glycosylation variants, and their relative levels were used for confirmatory diagnosis of CDG. Early and accurate diagnosis of CDG is crucial for the timely initiation of appropriate therapies, which can greatly enhance clinical outcomes. We aim to validate these findings further in our ongoing research using a larger cohort of samples to develop a fast and reliable diagnostic test for CDG.
Rabbit meat perceptions and consumption determinants among households in Nakuru County, Kenya
Authors: Anthony Muchira  , Benjamin Mutai  , Elijah Muange
Published: February 2025

The concept of the livestock revolution highlights significant changes in global animal production systems, driven by population growth, urbanization, and rising per capita incomes. This has resulted in unprecedented growth in the demand for animal-origin foods, particularly in developing countries. As a result, there is an urgent need for sustainable and nutritious alternatives to conventional livestock. Rabbit meat offers a viable solution due to its superior nutritional profile that includes high protein, low cholesterol, and essential vitamins. Despite its benefits, consumption of rabbit meat remains low compared to popular types of meat. Most of the previous research on rabbits has focused on production aspects and there is limited information on the current status of rabbit meat consumption. This study examines household perceptions and factors influencing rabbit meat consumption in Nakuru County, Kenya. Data was collected from 196 households using semi-structured questionnaires administered through face-to-face interviews. Data was analyzed using descriptive statistics and the double hurdle model. The study found that perceptions of rabbit meat by respondents were generally positive. Regression results show that decision to consume rabbit meat was influenced positively by respondent’s awareness of rabbit meat's nutritional benefits, perceived taste, knowing a rabbit keeper and distance to the market, and negatively by respondent’s age and level of education. Intensity of consumption was positively influenced by affordability of the meat and distance to market, but negatively by age and household size. The study recommends improving rabbit meat’s market accessibility and affordability and increasing awareness on its nutritional benefits be pursued.
Do sonho à realização
Authors: Santos Larissa Nogueira dos , De Paula Enio Freire
Published: February 2025

Resenha da obra "Do sonho à realização: Jornadas dos ex-estudantes da UFRN", organizada por Milton Schivani; publicada em Natal, RN, pela editora EDUFRN, em 2022.
Uso de Aplicativos Móveis nas Práticas Pedagógicas de Biologia no Contexto Brasileiro
Authors: Fonseca Fernanda Kainara Marcelino da , Silva Bruno Santana da
Published: February 2025

Diante dos documentos brasileiros que norteiam a educação e ressaltam a importância da educação digital, a escola pode repensar suas práticas pedagógicas para incorporar recursos digitais presentes na sociedade, como os aplicativos para smartphones. Deste modo, o objetivo dessa pesquisa foi realizar uma revisão da literatura para identificar como os aplicativos vêm sendo utilizados no ensino de Biologia no contexto brasileiro. Foram analisados 10 trabalhos (7 artigos e 3 dissertações) obtidos por meio de pesquisa no Portal de Periódicos da CAPES, BDTD e em 3 periódicos, a partir de critérios definidos, para responder a 5 questões de pesquisa. Observou-se que, de modo geral, os diferentes aplicativos têm sido utilizados para tornar as aulas mais dinâmicas, interativas e atrativas para os estudantes, promovendo a apropriação dos conceitos biológicos abordados. Entretanto, a maioria das iniciativas pedagógicas com aplicativos ainda partiram de pesquisadores e não de professores de Biologia que atuam na sala de aula.
Interseções da história:
Authors: de Abreu Pestana dos Santos Douglas Manoel Antônio
Published: February 2025

A História é configurada pela ação humana no decorrer do tempo e dentro do contexto do espaço social. Esta ação, embora intrinsecamente individual, frequentemente transcende o domínio pessoal e molda a sociedade de maneiras diversas. O ensino de História pode ser contemplado sob duas perspectivas distintas: a tradicional, de escopo mais limitado, e a amplificadora, de natureza mais inclusiva. Independentemente da abordagem, é imperativo que haja uma consciência histórica em cada indivíduo. Esta consciência implica na reflexão crítica do tempo vivido e na compreensão do seu significado histórico, que se concretiza através da identificação dos elementos culturais relevantes e de sua influência na formação do presente. A finalidade primordial do ensino de História reside em estabelecer uma conexão substantiva entre a vida cotidiana contemporânea e o passado historicizado. É essencial preservar a integridade e a qualidade dos conteúdos históricos adotados e utilizados, bem como sustentar a responsabilidade pedagógica e ética dos educadores e estudantes, tanto em relação a si mesmos quanto à sociedade. Desta forma, o ensino de História se estabelece não apenas como uma profissão, mas também como uma missão.
desenvolvimento da historiografia das organizações de luta armada contra ditadura militar no brasil (1990-...)
Authors: De Oliveira Masseroni Vinícius
Published: February 2025

O artigo que se segue busca realizar um levantamento bibliográfico sobre as organizações que encabeçaram a luta armada contra a Ditadura Militar no Brasil (1964-1985). No trabalho incluímos tanto obras acadêmicas (dissertações, teses, artigos e livros), bem como trabalhos memorialísticos e biográficos. O enfoque dos trabalhos, no texto ora apresentado, foi o estudo de uma organização de luta armada em específico, excluindo-se trabalhos “gerais” sobre as organizações de luta armada. O levantamento se deu, majoritariamente, nas plataformas “Catálogo de Teses & Dissertações – CAPES” e, para artigos, na “Scielo.org”. Como buscaremos evidenciar, trabalhos com essa temática começaram a ser desenvolvidos ainda em 1990, ganhando regularidade na primeira década deste século (anos 2000) e, na década recém findada, houve um aumento sensível na produção de dissertações e teses com o enfoque aqui proposto. Buscamos discutir, com base noutros trabalhos sobre a historiografia da Ditadura, o motivo desse aumento de produção. Por fim, como segundo objetivo, buscamos centralizar em um único local a grande massa de trabalho produzidos pela historiografia especializada, dessa forma, novos pesquisadores interessados pelo tema poderão, de maneira mais fácil, encontrar em nosso trabalho grande parte dos estudos sobre as diversas organizações armadas. A partir disso, cremos, poderão ter contato com os diversos estudos sobre uma determinada organização e/ou localizar lacunas na produção bibliográfica
Apresentação dos Artigos
Authors: Pimentel dos Santos Tiara Cristiana
Published: February 2025

Apresentação dos Artigos