bluuebunny/crossref_metadata_2025 huggingface dataset:
Investment Platforms in the Infrastructure of the Financial Market of the Russian Federation
Authors: Russkova Elena , Chaykina Elena , Chaykin Valery
Published: July 2019

Today investment platforms are at the stage of formation and development, and they do not occupy an essential share of the financial market. However, digital data processing, automated service provision, availability of financial resources and minimum costs of transaction processing are the factors stimulating market development in the Russian Federation. The article presents the research results of investment platforms in the Russian Federation. The authors gave
a comparative assessment of platforms in the domestic financial market. The article described the problems and prospects of developing crowdfund investments in the Russian Federation. In the analysis of investment platforms the author used general scientific methods, such as comparison, generalization and the logical approach. As a result of the conducted research the author draws the conclusion that the volumes and number of transactions on Russian investment platforms increase. However, this method of capital investment did not reach the level of necessary standards which would give the chance of its universal application. Moreover, this way of project financing implies essential risks which are much higher in the Russian Federation, than in the European countries. The lack of the platform activity state regulation and inability to control the platform at the Smart System level is the paramount reason of that risks.
Green Demand as a Factor and Condition of the Economy Ecological Modernization
Authors: Mishulina Svetlana , Bondarenko Tatiana
Published: July 2019

National and foreign analysts assess by common consent the demand for green products as the most important factor and condition determining the depth and speed of economy greening processes. From this viewpoint, the analysis of the processes forming green demand in the country is of great interest. The role of the tourism industry in the global economy and in the processes of transition to the green economic growth model defines the importance of the impact analysis of dynamic aggregate green demand for economy greening in the regions with recreation and tourism specialization. The article shows the results of studying the components of aggregate demand for the main institutional
economic entities: households, state and corporations. The paper analyzes the factors and conditions of its forming. A special focus is on the problems of forming green demand for tourism industry products. The low level of aggregate green demand in Russia is substantiated in the conclusion. This proves the fact that economic entities are not ready to change their behavior in production and consumption processes in order to reduce negative effect on the environment and requires urgent measures for the formation and efficient application of green demand stimulating devices and the environmental transformation of the economy. The results of analyzing the conditions and dynamics of forming aggregate green demand give much better sense of the mechanism of economy ecological modernization in general and its separate sectors and form a methodological basis for the determination of its structure and functions.
Some Factors Affecting What We Mean by Public
Authors: Brighouse Tim
Published: July 2019

After exploring what we mean by 'public', this article advances the argument that there have been two distinct periods in the post-war English schooling system and argues that the latest one, of markets and managerialism, ushered in on the back of neoliberal economic theories during
the 1980s, has internal contradictions if, as both parties declare, their aims for the schooling system are to secure 'equal opportunity', 'equity' and 'social mobility'. It concludes with an argument for changing five systemic influences external to schools – namely: governance; pupil
admissions; finance; curriculum exams; and accountability, and the existence in their present form of private schools – in order to make the system fairer.
A New Public Education for England
Authors: White John
Published: July 2019

This is an argument for a new public education for England, but not for a new public school. The focus should be on aims, not structures. We should ensure that all schools (community schools, private schools, academies and religious schools) are working to realise the same nationally
determined aims. The national set of aims should be determined not by ministers but by a Curriculum Commission. Its starting point should be the protection and nurturing of a liberal democratic community. This generates a number of major aims from which the Commission will also lay down more
specific ones. Schools should be free to employ their own curricular vehicles (e.g. subjects, projects, whole-school processes) and other policies in pursuing these aims.
The Role of the EGF Receptor in Sex Differences in Kidney Injury
Authors: Zhang Ming-Zhi , Sasaki Kensuke , Li Yan , Li Zhilian , Pan Yu , Jin Guan-nan , Wang Yinqiu , Niu Aolei , Wang Suwan , Fan Xiaofeng , Chen Jian Chun , Borza Corina , Yang Haichun , Pozzi Ambra , Fogo Agnes B. , Harris Raymond C.
Published: July 2019

Significance Statement

Sex differences in the predisposition to CKD development or progression are well known. However, the underlying mechanisms involved remain unclear. The authors found markedly greater renal EGF receptor (EGFR) expression levels in adult wild-type male versus female mice, and a similar sex difference in EGFR expression in normal adult human kidneys. In Dsk5 mutant mice with constitutive EGFR activation, males developed significant spontaneous glomerular and tubulointerstitial injury, whereas females were relatively spared. In female mice, oophorectomy did not affect renal EGFR expression, but testosterone increased it; in male mice, castration decreased renal EGFR expression. These findings indicate that differential expression in renal EGFR expression plays a role in sex differences in susceptibility to progressive kidney injury, one that may be mediated in part by testosterone.

Background

Sex differences mediating predisposition to kidney injury are well known, with evidence indicating lower CKD incidence rates and slower decline in renal function in nondiabetic CKD for premenopausal women compared with men. However, signaling pathways involved have not been elucidated to date. The EGF receptor (EGFR) is widely expressed in the kidney in glomeruli and tubules, and persistent and dysregulated EGFR activation mediates progressive renal injury.

Methods

To investigate the sex differences in response to renal injury, we examined EGFR expression in mice, in human kidney tissue, and in cultured cell lines.

Results

In wild type mice, renal mRNA and protein EGFR levels were comparable in males and females at postnatal day 7 but were significantly lower in age-matched adult females than in adult males. Similar gender differences in renal EGFR expression were detected in normal adult human kidneys. In Dsk5 mutant mice with a gain-of-function allele that increases basal EGFR kinase activity, males had progressive glomerulopathy, albuminuria, loss of podocytes, and tubulointerstitial fibrosis, but female Dsk5 mice had minimal kidney injury. Oophorectomy had no effect on renal EGFR levels in female Dsk5 mice, while castration protected against the kidney injury in male Dsk5 mice, in association with a reduction in EGFR expression to levels seen in females. Conversely, testosterone increased EGFR expression and renal injury in female Dsk5 mice. Testosterone directly stimulated EGFR expression in cultured kidney cells.

Conclusions

These studies indicate that differential renal EGFR expression plays a role in the sex differences in susceptibility to progressive kidney injury that may be mediated at least in part by testosterone.
Performance of GFR Slope as a Surrogate End Point for Kidney Disease Progression in Clinical Trials: A Statistical Simulation
Authors: Greene Tom , Ying Jian , Vonesh Edward F. , Tighiouart Hocine , Levey Andrew S. , Coresh Josef , Herrick Jennifer S. , Imai Enyu , Jafar Tazeen H. , Maes Bart D. , Perrone Ronald D. , del Vecchio Lucia , Wetzels Jack F.M. , Heerspink Hiddo J.L. , Inker Lesley A.
Published: July 2019

Significance Statement

Randomized controlled trials of CKD traditionally use clinical events that happen late in the course of CKD progression as study end points. Doing this requires large sample sizes and long follow-up periods that can make the studies very costly. The authors use statistical simulations to investigate circumstances in which using the change in GFR over time or GFR slope as a study end point reduces the required sample size or trial duration compared with clinical end points. They found that GFR slope performs better than clinical end points when patients’ initial GFRs are high and the treatment has no acute effect on GFR. The results along with other recent studies suggest GFR is a valid surrogate end point for CKD clinical trials that may allow for more efficient trials and help speed the development of new CKD therapies.

Background

Randomized trials of CKD treatments traditionally use clinical events late in CKD progression as end points. This requires costly studies with large sample sizes and long follow-up. Surrogate end points like GFR slope may speed up the evaluation of new therapies by enabling smaller studies with shorter follow-up.

Methods

We used statistical simulations to identify trial situations where GFR slope provides increased statistical power compared with the clinical end point of doubling of serum creatinine or kidney failure. We simulated GFR trajectories based on data from 47 randomized treatment comparisons. We evaluated the sample size required for adequate statistical power based on GFR slopes calculated from baseline and from 3 months follow-up.

Results

In most scenarios where the treatment has no acute effect, analyses of GFR slope provided similar or improved statistical power compared with the clinical end point, often allowing investigators to shorten follow-up by at least half while simultaneously reducing sample size. When patients’ GFRs are higher, the power advantages of GFR slope increase. However, acute treatment effects within several months of randomization can increase the risk of false conclusions about therapies based on GFR slope. Care is needed in study design and analysis to avoid such false conclusions.

Conclusions

Use of GFR slope can substantially increase statistical power compared with the clinical end point, particularly when baseline GFR is high and there is no acute effect. The optimum GFR-based end point depends on multiple factors including the rate of GFR decline, type of treatment effect and study design.
An Analysis of the Compliance Process on Tourism Policy Program Implemented by Local Government: Focusing on the Business Operators of Jeju Grand Sale
Authors:   The Tourism Sciences Society Of Korea, Lee Sang-Ho , Shin Seok-Min , Lee Chae-Wan
Published: July 2019

Although tourism business operators recognize that the economic benefits from the program implemented by local government is not significant, they are constantly involved in the program. This study tried to analyze this phenomenon using the theory of policy compliance. Specifically, the study aimed to analyze the factors of compliance and the effects of these factors on compliance and participation continued-intention. For these purposes, the compliance factors were composed largely of variables related to policy content, implementation institution, and policy target group. The survey was limited to the director of the tourism businesses in Jeju that have participated in the program more than once. A total of 321 responses were retrieved, and 275 among them were used for final analysis. The result showed that reliability among the implementation institution factors and business feasibility among policy target group factors are respectively affecting to the compliance. The study also revealed that consistency among policy factors had a negative effect on the compliance. Based on these findings, this study proposed some implications to successfully operate the policy program and to ramp up the tourism industry in Jeju region.
Workshop on Models for Copyright Education in Information Literacy
Authors: Hinchliffe Lisa Janicke
Published: July 2019

The Workshop was organized the IFLA Information Literacy Section and the IFLA Copyright and Other Legal Matters Advisory Committee to provide a forum for discussing models for education on copyright, licensing, and related legal matters within the framework of library information literacy programs. With more than 14 countries represented, the papers and discussions were far-ranging and comprehensive, touching on issues of pedagogy, instructional design, learning theory, author rights, copyright limitations and exceptions, applications of the law nationally, international copyright, open access, and education for library and information science practitioners. The papers in this special issue started as presentations at the workshop but were further developed based on feedback and then through peer review before publication.
AS “PORTAS DE ENTRADA” DA IGREJA ADVENTISTA E O DISCIPULADO: UMA ANÁLISE INICIAL DA REALIDADE DA UNIÃO CENTRAL BRASILEIRA
Authors: Dias Marcelo E. C.
Published: July 2019

A Igreja Adventista do Sétimo Dia (IASD) no Brasil tem se apoiado em frentes missionárias de trabalho tais como escolas adventistas, séries de evangelismo público, clubes de desbravadores, escola sabatina, classes bíblicas e contatos pessoais -- “portas de entrada” para novos membros. O conceito de discipulado tem sido enfatizado como necessário para corrigir o fenômeno atual: baixa retenção de novos membros. Esta pesquisa analisa a realidade do discipulado e essas frentes de evangelização baseada em revisões bibliográficas e de estatísticas oficiais da IASD publicadas pela Associação Geral (AG), pela Divisão Sul-Americana (DSA) e fornecidas pelo sistema de secretaria, o Adventist Church Management System (ACMS) em relação à União Central Brasileira (UCB). Observou-se que diferentes frentes missionárias enfatizam aspectos distintos do processo de discipulado e, portanto, precisam estar coordenadas para que haja crescimento quantitativo e qualitativo.
Marcas digitales y empresas de la Web 3.0: análisis de redes sociales y análisis temático de las actividades de los usuarios y patrones de comportamiento del comercio minorista en línea
Authors: Sharafi Farzad Fatemeh , Kolli Shaghayegh , Soltani Tohid , Ghanbary Saeid
Published: July 2019

Teniendo en cuenta la importancia de las empresas Web 3.0 en el comercio minorista en línea, este artículo explica cómo operan estas empresas en el contexto iraní. DigiKala, es un minorista en línea que ha sido una de las empresas emergentes (start-ups) más exitosas en Irán y ha ganado entre el 85 y el 90% del mercado de minoristas en línea del país. Esta empresa ha comenzado a transformar su cadena de valor hacia un negocio de plataforma. Por otro lado, Twitter como microblogging de redes sociales gratuito, ha sido una de las herramientas más importantes en el mercado en línea, ya que los clientes, especialmente en los mercados digitales, comparten sus comentarios positivos y negativos con respecto a su experiencia de compra. En esta investigación, en primer lugar, se utilizó el método de análisis de redes sociales (SNA) para comprender las relaciones y los nodos individuales en la red. Luego, se aplicó un método de análisis temático para analizar los trinos (tweets) enviados para lograr los patrones de comportamiento de los usuarios. El uso de diferentes redes sociales, como Twitter, y compartir los comentarios también es válido para DigiKala como empresa Web 3.0. Esta investigación estudió la red de tweets en eventos especiales, a saber, el Black Friday, en el que DigiKala ofreció descuentos considerables a sus clientes. Algunas implicaciones de nuestra investigación también se presentan al final de este artículo.
O potencial de desenvolvimento do setor alimentício em Naviraí: uma análise de fatores locacionais
Authors: Louza Caroline Achilles , Resch Sibelly
Published: July 2019

O objetivo desta pesquisa é investigar o potencial de desenvolvimento do setor alimentício a partir da análise de fatores locacionais da região de Naviraí. O estudo tem como questão de pesquisa: quais fatores locacionais favorecem ou restringem o desenvolvimento do setor alimentício na região de Naviraí? A pesquisa caracteriza-se como qualitativa, de natureza exploratória. Os dados foram coletados por meio de pesquisa documental e bibliográfica. Os resultados apontaram que: a região não produz uma grande variedade de matérias-primas para industrialização, porém, já possui indústrias que beneficiam os principais produtos (bovinos, suínos e mandioca). A cidade possui localização estratégica, tendo boa infraestrutura para o transporte rodoviário terrestre, energia e água. Há disponibilidade de mão de obra e os custos são baixos comparativamente a outros municípios. A taxa de educação formal é baixa, porém, o município conta com o sistema S para qualificação do trabalhador. O município e o estado oferecem incentivos fiscais e tributários relevantes para instalação de indústrias. Conclui-se, nessa primeira etapa da pesquisa, que, de modo amplo, os fatores locacionais investigados favorecem a instalação de indústrias de alimentos no município. Acredita-se que é preciso aprofundar a investigação sobre a complementaridade das indústrias, conforme proposto pela teoria marshalliana, identificando o potencial para o surgimento de indústrias subsidiárias próximas e serviços especializados.

PALAVRAS-CHAVE: Desenvolvimento endógeno; Indústria de alimentos; Fatores locacionais; Mato Grosso do Sul.
Capital Social em Brasília na Perspectiva de Nativos e Emigrantes
Authors: Chaebo Gemael , Silveira Natália Fernandes , Silveira Vítor Cardoso da
Published: July 2019

Este artigo pretende identificar e comparar o capital social em Brasília na perspectiva de nativos e emigrantes. O marco teórico baseou-se no constructo sobre capital social, tentando identificar fatores que poderiam demonstrar sua presença ou ausência no contexto brasiliense. Com relação aos métodos, a pesquisa englobou apenas questões relacionadas a confiança para que se pudesse ter condições de inferir sobre o capital social nos diferentes grupos. A pesquisa foi qualitativa e descritiva, na qual a estratégia de investigação utilizada foi o estudo multicasos, que permite a comparação entre grupos de participantes. O instrumento de coleta utilizado foi um roteiro contendo apenas questões abertas aplicado a oito estudantes de Pós-Graduação, sendo quatro deles nativos e quatro emigrantes à cidade. Os dados foram analisados por meio de análise de conteúdo. Os principais resultados indicam que os emigrantes sensivelmente confiam mais em seus pares, nas autoridades públicas e nas instituições do que os participantes nativos. A pesquisa contribui para (a) entender as percepções referentes a confiança entre nativos do Distrito Federal e emigrantes; assim como, este estudo permite (b) inferir sobre o capital social existente em cidades “construídas” artificialmente.

PALAVRAS-CHAVE: Capital Social. Confiança. Estudo multicasos.
Pengaruh Field Trip terhadap Kemampuan Literasi Sains dan Sikap terhadap Sains Siswa SMA pada Materi Ekosistem
Authors: Dinata Anita Nurlela , Adisendjaja Yusuf Hilmi , Amprasto Amprasto
Published: July 2019

The aim of this research is to know the influence of field trip on scientific literacy and attitude towards science of senior high school students before and after the field trip implemetation in ecosystem learning. The research was conducted in SMAN I Pangalengan. The method which was used in this research is Quasi Experimental with Nonequivalent Control Group Design as the design. The result shows that there are significant difference in scientific literacy between the control class where discussion was applied and the experimental class where field trip was applied, with t = 0.003 and α = 0.05. The result also shows that there is a significant attitude between the control and experimental class, with t = 0.003 and α = 0.05. Those results show that field trip gives significant effect on high school student's scientific literacy and attitude towards science in ecosystem concept.
Role of P-glycoprotein in the pharmacotherapy of pregnant women
Authors: Popova N. M. , Shchulkin A. V. , Chernykh I. V. , Esenina A. S. , Gradinar M. M. , Yakusheva E. N.
Published: July 2019

This review addresses the function of the protein-transporter glycoprotein-P (Pgp, ABCB1 protein) and the expression of its encoding gene MDR1/mdr1 throughout the gestational period in humans and animals. We discuss the relationship between the transporter function and the hormone fluctuations during pregnancy. We cite studies on the association between the MDR1/mdr1 gene polymorphisms and the hemato-placental barrier permeability for Pgp substrates, as well as fetal malformations. Under a separate section, drugs commonly used in pregnant women are characterized in terms of their roles as substrates, inducers or inhibitors of the Pgp transporter.
EBEVEYNLİK BİÇİMİNİN KİŞİLİK ÖZELLİKLERİ, BENLİK SAYGISI VE YAŞAM DOYUMUNU YORDAMA GÜCÜ
Authors: Tuzgöl Dost Meliha , Aytaç Mert , Kıbrıslıoğlu Uysal Nermin
Published: July 2019

Bu araştırmanın amacı, ebeveynlik biçiminin kişilik
özellikleri, benlik saygısı ve yaşam doyumunu yordama gücünü araştırmaktır.
Araştırmada ilişkisel araştırma deseni kullanılmıştır. Araştırma grubu
Ankara’da bir devlet üniversitesinin Eğitim Fakültesinin çeşitli bölümlerinde
okumakta olan 441 lisans öğrencisinden oluşmaktadır. Katılımcıların 375’i (%
85) kadın, 66’sı (% 15) erkektir. Öğrencilerin yaş aralığı 18-36 olup, yaş
ortalaması 20.71’dir (Ss: 1.82). Araştırmada, Young Ebeveynlik Ölçeği,
Sıfatlara Dayalı Kişilik Testi, 
Rosenberg Benlik Saygısı Ölçeği-Benlik Saygısı Alt Ölçeği, Yaşam Doyumu
Ölçeği ve Kişisel Bilgi Formu kullanılmıştır. Ebeveynlik biçimlerinin,
öğrencilerin beş büyük faktör kişilik özelliklerini, benlik saygısı ve yaşam
doyumunu yordama gücünün incelenmesi amacıyla çoklu regresyon analizi
yapılmıştır. Bazı ebeveynlik biçimlerinin üniversite öğrencilerinin nevrotizm,
dışadönüklük, deneyime açıklık, yumuşak başlılık, sorumluluk, benlik saygısı ve
yaşam doyumunu anlamlı olarak yordadığı saptanmıştır. Sonuçlar tartışılmış ve
çeşitli önerilerde bulunulmuştur.
A SYSTEMATIC PERSPECTIVE ON SUPPLY CHAIN IMPROVEMENT BY USING LEAN SIX SIGMA AND AN IMPLEMENTATION AT A FERTILIZER COMPANY
Authors: Dönmez Cem Çağri , Yakar Burak
Published: July 2019

The purpose of this
study is to review the supply chain processes of an enterprise using Lean Six
Sigma tools and question the adequacy of the existing situation. The cost items
in the supply chain of the company are discussed with the finance officers and
listed as insurance expense, warehouse rent, financial expense and cost of
spoiled goods. The DMAIC (Define, Measure, Analyze,
Improve, Control) technique was used to decrease inventory time and inventory
amount. By defining the current situation of the system in the Define phase,
the process is analyzed with the SIPOC tool, and a CTQ diagram is created to
determine the project metrics. In the Analyze phase, the average inventory is
calculated using the Kanban method. Then, the reasons that increase the
inventory are analyzed by a fishbone diagram, and after the necessary
precautions, a control mechanism is established to prevent possible side effects
of the project.
2018 TÜRKÇE ÖĞRETİM PROGRAMI ÇERÇEVESİNDE HAZIRLANAN 8. SINIF TÜRKÇE DERS KİTABININ DEĞERLENDİRİLMESİ
Authors: Çarkıt Cafer
Published: July 2019

Bu
çalışmada 2018 Türkçe Öğretim Programına göre hazırlanmış 8. sınıf Türkçe ders
kitapları değerlendirilmektedir. Bu çerçevede kitapta yer alan etkinliklerin
okuma, yazma, konuşma ve dinleme ile dil bilgisi alanlarına yönelik dağılımı
ile metinlerin türler açısından kullanım sıklıkları tespit edilmiştir. Ayrıca
kitabı okutan 8 Türkçe öğretmeni ile görüşme yapılarak kitaba yönelik öğretmen
görüşleri alınmıştır. Araştırmada veriler doküman incelemesi ve yarı
yapılandırlmış görüşme formu ile toplanmıştır. Elde edilen verilerin
analizinde nitel araştırma yöntemlerinden içerik analizi kullanılmıştır.
Veriler araştırma sorularının ortaya koyduğu temalara göre düzenlenmiştir.
Ulaşılan bulgular araştırmanın alt problemlerine göre tanımlanmıştır.
Araştırmada etkinliklerin öğrenme alanlarına göre düzenli bir dağılım
göstermediği, bilgilendirici ve öyküleyici metinlerin şiir türüne göre daha
fazla olduğu sonuçlarına ulaşılmıştır. Ayrıca öğretmenler  metin seçimi, şiir seçimi ve tema sözlüğüne yer
vermesi açısından kitabı olumlu bulmakta; öğrencilerin ilgisini çekmemesi,
güncel konuları içermemesi, tema değerlendirmelerinin basit olması ve görsel
içeriklerin zengin olmaması yönünden ise kitabı olumsuz bulmaktadır.
Applying a Self-Regulation and Communication Framework to Autism Intervention
Authors: Binns A.
Published: July 2019

Accumulating evidence demonstrates the important role of self-regulation in children’s academic success and development of social and emotional wellbeing. Binns, Hutchinson and Oram Cardy proposed a framework designed to help clinicians to understand the impact that stress can have on children’s ability to attain a state of regulation and engage with their environment and, simultaneously, to support children’s communication and self-regulation capacities. In this article, I review challenges in the domain of self-regulation specific to children with autism and share special considerations for applying our framework to autism intervention.
A Trampoline Group: Feasibility, Implementation, and Outcomes
Authors: Schoen S.A. , Einck C. , Valdez A. , Spielmann V. , Miller L.J.
Published: July 2019

This paper reflects two studies designed to explore feasibility and outcomes of a movement-based trampoline group for children with autism and/or sensory processing challenges. A pre experimental A- B single subject pilot study was used to examine feasibility and sensitivity of outcomes, followed by a single group pretest posttest design to examine outcomes. Each group received eight to ten, 50-minute sessions of trampoline activity.
Motor outcomes were administered once a week as well as pre- post- measures of motor function. Measures from Study 1 informed Study 2. Parent report pre- post- measures of social functioning were added to Study 2. All procedures were feasible and sensitive outcome measures were identified. In Study 1, outcomes (e.g. broad jump, heel toe walking, beads in box, beads on rod and hand strength) did not consistently show change. Broad jump and one foot standing balance were suggested for future use. In Study 2 significant improvements were noted in broad jump. Social competency and participation as measured by the Social Skills Improvement System, and the Sensory Processing Three Dimensions Occupational Performance Scale showed significant change. A visual analog scale completed by parents was also sensitive to changes in both motor and social abilities. This study demonstrated the feasibility of conducting a trampoline group program for children with autism and/or sensory
processing challenges. Motor gains were reported as well as gains in psychosocial functioning.
VERIFICATION OF HISTORICAL LANDSLIDE INVENTORY MAPS FOR THE PODSLJEME AREA IN THE CITY OF ZAGREB USING LiDAR-BASED LANDSLIDE INVENTORY
Authors: Bernat Gazibara Sanja , Krkač Martin , Mihalić Arbanas Snježana
Published: July 2019

Data on landslide locations in the Podsljeme area can be found in three historical landslide inventory maps. Inventory maps from 1979 and 2007 are made based on geomorphological field mapping and historical records while an inventory map from 2017, compiled for the study area (21 km2), is based on LiDAR data acquired in December 2013. A comparison of three landslide inventory maps was performed with three tests based on landslide statistics, frequency-area distribution, geographical discrepancy of landslides and landslide density maps. The results show significant differences in the number of identified landslides as well as in the size and distribution of landslides. A comparison of inventories also showed the unreliability of the existing historical inventories and usefulness of LiDAR data for preparation of complete landslide inventory maps. LiDAR-based inventory for the Podsljeme area could be a valuable tool for a wide range of users i.e., decision-makers, land developers and environmental and civil defense agencies. It is also necessary for landslide susceptibility and hazard mapping, which is a prerequisite for landslide risk reduction.
The simultaneous effect of moisture and pyrite on coal spontaneous combustion using CPT and R70 test methods
Authors: Saffari Amir , Sereshki Farhang , Ataei Mohammad
Published: July 2019

Among fossil fuels, coal is the most widely used all over the world for generating power and electricity and it is a stable source of energy. Despite all these beneﬁts, coal mining has serious hazards, such as coal spontaneous combustion. There are many factors that inﬂuence the tendency for coal to spontaneously combust in coal mines. Pyrite can promote the risk of this phenomenon. This promotion is accelerated by the combination of pyrite and moisture content at the same time. This combination is very rarely discussed in literature. So, in this research, the accelerating eﬀect of reactive pyrite and moisture content on coal spontaneous combustion was measured experimentally using crossing point temperature (CPT) and R70 test methods. For this purpose, a new experimental apparatus was assembled and made in Iran. Reaction rate data obtained from the experimental results showed that pyrite has a twofold action. It ﬁrst catalyzes the oxidation reaction. Then, in a moist environment, pyrite is itself oxidized, which provides a secondary heat source, and so accelerates the process of coal spontaneous combustion. Since the pyrite oxidation reaction consumes moisture, there is a mutual eﬀect of accelerated heating as less heat is used up in moisture evaporation. The results show that pyrite content can linearly accelerate the coal spontaneous combustion process, while moisture content under 20% increases it, and if the moisture exceeds 20%, the rate of this process is reduced. The results of this research are helpful in the assessment and management of coal spontaneous combustion issues in coal mines.
Molecular Identification of Human Sporotrichosis in Korea
Authors: Kim Hye Ri , Shin Dong Hoon , Lee Jee-Bum , Choi Jong Soo
Published: July 2019

Background: Sporotrichosis is a common deep mycosis caused by the Sporothrix schenckii complex. Until 2016, no molecular studies had been conducted on these fungi, and all the included strains were reported as S. schenckii. However, investigations conducted in northeast China, Japan, and India revealed that S. globosa was the most prevalent Sporothrix species, whereas S. schenckii sensu stricto was reported very rarely. Objective: To investigate the accurate prevalent causative species of sporotrichosis among strains reported as S.schenckii in Korea. Methods: We isolated strains of Sporothrix spp. Prevalent in Korea from fungus collection centers or private collections and reviewed the available literature on molecular studies of strains from this region. We found five S. schenckii (1998-2016) and three S. globosa (2016-2018) strains. Ribosomal DNA internal transcribed spacer (ITS) sequences of these strains were compared with those of the S. schenckii complex strains. Results: The ribosomal ITS sequences of the eight strains were 100% identical with that of S. globose. No S. schenckii sensu stricto was found. In addition, a study on the molecular analysis of Korean S. schenckii published by Ishizaki et al. (2004) demonstrated that the eight strains were of the mitochondrial subtype group B (S. globosa). Thus, all the 16 strains examined within the Korean S. schenckii complex were determined to be S. globosa. Conclusion: In summary, S. globosa is the causative species within the tested Korean sporotrichosis cases reported between 1998 and 2018. Based on our analyses, S. globosa, and not S. schenckii, may be the predominant species in Korea.
A Case of Deep Cutaneous Purpureocillium lilacinum Fungal Infection in an Immunocompetent Patient
Authors: Kim Hyojin , Cho Gyeong Je , Kim Jong Uk , Jin Woo Jung , Park So Hee , Moon Seung Hyun , Seol Jung Eun , Shin Jeong Hwan
Published: July 2019

Purpureocillium is a genus of saprophytic fungi that is commonly found in soil or rotting material. Although rarely a pathogen in humans, it can cause serious infections in immunocompromized patients. An 85-year-old woman presented with a 2-week history of pruritic erythematous plaques with yellowish crusts on her right forearm and dorsal hand. Histopathological analysis identified fungal hyphae and spores in the dermis, and Purpureocillium lilacinum was identified through tissue culture, polymerase chain reaction, and DNA sequencing. The skin lesion barely responded to 4 weeks of itraconazole treatment but improved upon the addition of terbinafine. The skin lesion was completely cured after 12 weeks, with no recurrence to date. Here, we report a rare deep cutaneous fungal infection caused by P. lilacinum in an immunocompetent patient and postulate that, in this case, the patient's agricultural lifestyle increased the possibility of P. lilacinum infection.
La información pragmática sobre las locuciones en el diccionario
Authors: Penadés Martínez Inmaculada
Published: July 2019

El punto de partida se sitúa en la concepción de la Pragmática como disciplina que se ocupa del uso de la lengua en la comunicación. Desde esta perspectiva, el objetivo del artículo es mostrar cómo un diccionario de locuciones ofrece informaciones lexicográficas de carácter pragmático. El uso de la lengua en la comunicación se manifiesta en ejemplos concretos que pueden ser objeto de análisis ya sea pragmático, ya sea gramatical, semántico, sociolingüístico, etc. Por eso los datos presentados tienen su fundamento en un amplio conjunto de ejemplos de locuciones verbales de la variedad del español de España, tomados del CREA, del CORDE, de internet y de textos orales y escritos. En el artículo se comprueba que no es posible establecer el lema de una locución, distinguir acepciones, definirla y marcarla diafásicamente sin un análisis pragmático de los contextos en que se utiliza. Este análisis tiene consecuencias en la elaboración del diccionario por parte del lexicógrafo y, asimismo, implicaciones pragmáticas respecto al usuario en relación con una utilización adecuada de la lengua que conduzca al éxito comunicativo.
Los inicios de la lexicografía hispano-japonesa
Authors: Rojo-Mejuto Natalia
Published: July 2019

El objetivo de este artículo es analizar los diccionarios plurilingües publicados en Japón durante los siglos XVI y XVII en el contexto de las misiones religiosas. Para ello se propone una caracterización de la lingüística misionera hispano-japonesa y se define el contexto en el que nacen estas obras lexicográficas y sus objetivos. Asimismo, se estudia la evolución del proceso de aprendizaje de la lengua japonesa por parte de los misioneros españoles, así como la autoría colectiva de las obras y los condicionantes tipográficos. En particular, se analizan el Dictionarium Latino Lusitanicum ac Iaponicum (1595), el Vocabulario da lingoa de Iapam (1603) y el Vocabulario de Iapon (1630) y se defiende su vigencia actual tanto en el estudio de los niponismos en lengua española como en su tratamiento lexicográfico.
Pedagoxías alternativas na educación infantil
Authors: Díaz Portillo María Noelia , Otero Urtaza Eugenio Manuel
Published: July 2019

Este estudo persegue aproximarnos á historia presente partindo do auxe actual das pedagoxías alternativas na educación infantil, potenciando a súa divulgación. Con esta intención, realizouse unha revisión bibliográfica sobre varios proxectos innovadores (Waldorf, Amara Berri, Reggio Emilia, Centros democráticos, Educación no fogar…), a cal se centrou en como evolucionou a educación na natureza ao longo dos anos e as súas particularidades. Xusto despois a investigación virou arredor de dúas escolas galegas ao aire libre (Nenea, medrar creando e Amadahi), afondando nos seus espazos, na súa organización temporal, nas actividades primordiais, nos materiais dispoñibles e nas relacións establecidas nelas mediante observacións e cuestionarios realizados ás mestras co fin de coñecelas máis polo miúdo.
Isabel Vilafranca; Conrad Vilanou (eds.): Giner i la Institución Libre de Enseñanza, des de Catalunya. Cent anys després de la mort de Francisco Giner de los Ríos (1839-1915)
Authors: Porto Ucha Ángel Serafín , Vázquez Ramil María Raquel
Published: July 2019

Recensión de libro: Isabel Vilafranca; Conrad Vilanou (eds.) (2018). Giner i la Institución Libre de Enseñanza, des de Catalunya. Cent anys després de la mort de Francisco Giner de los Ríos (1839-1915).
Emilio Lledó: Sobre la educación. La necesidad de la Literatura y la vigencia de la Filosofía
Authors: Iglesias Galdo Ana
Published: July 2019

Recensión de libro: Emilio Lledó (2018). Sobre la educación. La necesidad de la Literatura y la vigencia de la Filosofía.
Pedro M. Moreno Martínez (ed.): Educación, historia y sociedad. El legado historiográfico de Antonio Viñao
Authors: Malheiro Gutiérrez Xosé Manuel
Published: July 2019

Recensión de libro: Pedro M. Moreno Martínez (ed.) (2018). Educación, historia y sociedad. El legado historiográfico de Antonio Viñao.
Актуальные проблемы внедрения цифровых технологий в промышленность России
Authors: Комарова Вера Владимировна
Published: July 2019

В статье рассматривается необходимость адаптации экономики России к требованиям нового технологического уклада. Выделяются основные вызовы цифровой экономики в России. Среди них: 1) недоступность критических технологий; 2) неразвитость цифровой экономики; 3) несовершенство законодательного регулирования цифровой экономики; 4) бюрократические и административные барьеры для включения частного сектора в программу развития цифровой экономики; 5) риск переоценки ряда критических цифровых технологий
Антикризисный компонент как инструмент маркетинговой адаптации предприятия в условиях априорной нестабильности
Authors: Щепакин Михаил Борисович , Губин Виктор Анатольевич , Хандамова Эва Фризовна
Published: July 2019

Определены маркетингово-поведенческие причины формирования нестабильных (кризисных) условий функционирования рынка. Обозначена потребность в модуляционных регулирующих воздействиях со стороны государства в условиях обострения противоречий внутри общества и бизнеса. Установлена взаимосвязь рыночного давления и нарастающей маркетинговой симуляции. Раскрыта экономическая природа маркетингового поведенческого модулятора. Расширено представление об антикризисном компоненте предприятия как инструменте маркетинговой адаптации предприятия к вызовам рынка и меняющимся требованиям государства, бизнеса, общества и потребителей. Разработана модель маркетингового управления конкурентной
позицией предприятия посредством активизации его антикризисного компо-нента
Leader's Influence and Communication Styles on the Culture of Innovation in FIFGROUP
Authors: Iswanti Margareta Enik , Rahmanto Andre , Muktiyo Widodo
Published: July 2019

This papers learn about leadership dan communication styles on the culture of innovation in FIFGROUP, The leader are be visionary, competence, be able ti influence team for innovation and encourage his team and make effectivelly communications to take part in the organization. Indicator Success an organization when the leader walk the talk, able to effective communication, has contibution performance, focus to  innovation process and be role model as part of the innovation culture organization.When Organization face the problem about innovation, innovation is suck and useless for another subordinat buat for company innovation is must be create. Case Study in (PT. FEDERAL INTERNATIONAL FINANCE) FIFGROUP one of member Astra International very interesting because in FIFGROUP on of  Astra International member focus on innovation but innovation not yet a part of daily task and performance. Success Indicator function leader as role model is  important thing, internalization Values, mindset inovation is important to make FIFGROUP sustainability, effective Communication and sense or urgency when organization face the problem and  able love change in era digital.
Cellular apoptosis: An alternative mechanism of action for caspofungin against Candida glabrata
Authors: Aryamloo Parisa , Asgarian-Omran Hossein , Aslani Narges , Hossein-Nataj Hadi , Shokohi Tahereh , Badali Hamid , Nabili Mojtaba , Abdollahi Gohar Atefeh , Moazeni Maryam
Published: July 2019

Background and Purpose: Although the mechanism of action for echinocandins isknown, the physiological mechanisms by which these antifungal agents cause cell deathvia the classical apoptotic pathways are not well-defined yet. Regarding this, the presentstudy aimed to evaluate the mechanisms of caspofungin-induced Candida glabrata celldeath.Materials and Methods: For the purpose of the study, the minimum inhibitoryconcentration (MIC) of caspofungin against C. glabrata (ATCC 90030) was determinedusing the broth microdilution reference method (CLSI M27-A2 and M27-S4). Theannexin V and propidium iodide staining was performed to determine the way throughwhich caspofungin acts against C. glabrata (i.e., through the induction of apoptosisand/or necrosis). Additionally, the possible effect of caspofungin on inducing theexpression of two apoptotic genes, namely MCA1 and NUC, was studied using the realtime polymerase chain reaction assay.Results: According to the obtained MIC value (0.5 µg/mL), C. glabrata, exposed to0.25, 0.5, and 1 µg/mL of caspofungin, exhibited the features of late apoptosis/necrosisafter 18 h of incubation. Furthermore, the use of 0.25, 0.5, and 1 µg/ml caspofungininduced apoptosis (early/late) in 14.67%, 17.04%, and 15.89% of the cells, respectively.The results showed a significant difference between the percentages of early-apoptoticcells at the three concentrations (P<0.05). In addition, the rate of necrosis wassignificantly greater than that of apoptosis in response to caspofungin. Accordingly,necrosis occurred in 71.26%, 71.26%, and 61.26% of the cells at the caspofunginconcentrations of 0.25, 0.5, and 1 µg/mL, respectively (P<0.05). The analysis of the datain the REST software demonstrated a significant increase in the expression of MCA1 andNUC1 genes (P<0.05).Conclusion: As the findings of the present study indicated, caspofungin promoted bothnecrosis and apoptosis of C. glabrata cells at concentrations higher than or equal to theMIC value.
Effect of benomyl and diazinon on acquired azole resistance in Aspergillus flavus and expression of mdr1 and cyp51c genes
Authors: Akbari Dana Maryam , Hashemi Seyed Jamal , Daei Ghazvini Roshanak , Khodavesi Sadegh , Modiri Mona , Nazemi Ladan , Darabian Sima , Rezaie Sasan
Published: July 2019

Background and Purpose: Aspergillus flavus is an important pathogen in immunodeficient patients. Due to the abundance of this fungus in nature, fungicides are commonly used to preserve and maintain agricultural products. Long-term exposure to these pesticides can lead to the induction of drug resistance in this fungus. Materials and Methods: For the purpose of the study, 10 strains of A. flavus ATCC 204304 were cultured in benomyl and diazinon pesticides at the concentrations of 62.5, 125, 250.500, 750, 1000, 1500, 2000, and 2500 mg/L in nine steps. Morphological changes and resistance to voriconazole, itraconazole, and amphotericin B were evaluated at the end of each step. Subsequently, changes in the expression of mdr1 and cyp51C genes were studied in the strains showing drug resistance. Results: The results showed that during the nine stages of the adjacency of strains with benomyl and diazinon at different concentrations, resistance to voriconazole, itraconazole, and amphotericin B in these toxins increased by 30% and 10%, respectively. In addition, the microscopic examination of resistant strains revealed the absence of sporulation, and only mycelium was found. Macroscopically, the color of the colonies changed from green to white. Furthermore, the investigation of the expression of mdr1 and cyp51c genes in these strains showed a decrease and increase in adjacency with diazinon and benomyl, respectively. Conclusion: As the findings indicated, exposure to agricultural pesticides can lead to the incidence of morphological changes and resistance to amphotericin B, itraconazole, and voriconazole in the sensitive species of A. flavus by altering the expression of genes involved in drug resistance.
Isolation, characterization, and molecular identification of Candida species from urinary tract infections
Authors: Gharanfoli Amin , Mahmoudi Elaheh , Torabizadeh Roya , Torabizadeh Roya , Katiraii Farzad , Faraji Saeid
Published: July 2019

Short communication Background and Purpose: Candida species are reportedly the most common human fungal pathogens. The incidence of urinary tract infections (UTIs) caused by Candida pathogens has increased in recent decades. However, such infections rarely occur in the absence of any predisposing factors. Regarding this, the aim of the present study was to identify the Candida species causing UTIs and determine the predisposing factors for candiduria. Materials and Methods: The current study was conducted on 1,450 urine samples obtained from patients suspected of UTI. Out of this number, 19 cases were candidiasis, and 2 cases were mixed infections caused by bacteria and fungi. Candida species were diagnosed differentially using the germ tube test, colony staining on CHROMagar medium, intracellular beta-glucosidase enzyme activity, and glucose absorption pattern. Then, the colonies with the same morphology were confirmed by the DNA sequencing of internal transcribed spacer regions. Results: According to the results, 38%, 28.6%, 14.3%, and 9.5% of the isolates were identified as C. albicans, C. glabrata, C. tropicalis, and C. kefir/C. krusei, respectively. The presence of one or more predisposing factors was proved in all patients in whom diabetes was the most prevalent predisposing factor (21.1%). Conclusion: Based on the obtained results, C. albicans species was the most prevalent fungal species. In addition, urinary fungal infections were less prevalent than bacterial urinary infections.
An Overview of the Epigenetic Modifications of Gene Expression in Tumorigenesis
Authors: Sadeghi Amiri Leili , Barzegar Ali , Rafiei Alireza , Amjadi Omolbanin
Published: July 2019

The five leading causes of cancer-related deaths are lung (1,760,000 deaths), colorectal (862,000 deaths), stomach (783,000 deaths), liver (782,000 deaths), and breast (627,000 deaths) cancers. Epigenetic changes can alter chromatin compaction, leading to the regulation of gene expression without changing the primary DNA sequence. Epigenetic mechanisms are normally involved in cellular processes such as genomic stability, chromosome X inactivation, and embryonic development and differentiation. Similar to other types of chromatin modifications, DNA methylation has been verified to affect the expression of various genes. Any impairment in these mechanisms alters the regulation of gene expression and can contribute to malignant cell transformation. Over the past few years, extensive innovations within the field of epigenetics have encouraged its application as a major strategy for the treatment of important diseases such as cancer.