bluuebunny/crossref_metadata_2025 huggingface dataset:
Cytotoxic effects of persistent organic pollutants on the freshwater snail (Lanistes carinatus) in Kafr El-Zayat, Egypt
Authors: Abdel-Halim K. Y. , Mona M. H. , Giesy J. P. , Shouker F. A. , Osman S. R.
Published: October 2019

Effects of industrial and municipal wastewaters on the freshwater snail,Lanistes carinatus, were evaluated. Concentrations of some chemicals in some effluents were greater than permissible limits promulgated internationally by various jurisdictions. Pesticides and polychlorinated biphenyls (PCBs) observed in tissues of snails collected during summer were greater than those measured in snails collected during winter. Catalase activities observed during autumn were greater than those observed during other seasons. Activities of catalase were greater at all sites near sources of contamination than in snails from the reference site (S6). Lactate dehydrogenase activity was also greater at all sites relative to the location designated as the reference (S6), at which activities did not exceed 8.10 U/L. Patterns of genomic DNA in snails, as determined by use of OPA-02 primer, were significantly different among sites. Location S1 (Belshay village) exhibited 11 bands, followed by S2 (El-Demer zone) and S5 (Rosetta branch) which exhibited 6 bands. In contrast, all sites exhibited greater numbers of bands when the OPA-08 primer was used. Thus, DNA fingerprinting, lactate dehydrogenase, and catalase offer useful biomarkers in ecotoxicology and risk assessment programs.
Background seismicity and seismic monitoring in the Lai Chau reservoir area
Authors: Lizurek Grzegorz , Wiszniowski Jan , Giang N. V. , Van D. Q. , Dung L. V. , Tung V. D. , Plesiewicz Beata
Published: October 2019

Reservoir-triggered seismic activity depends not only on the technical characteristics of the future reservoir (filling volume, the height of water column) but also on the seismo-tectonics and the natural seismic processes occurring in the area before construction of an artificial reservoir. Passive seismic monitoring was realised near Lai Chau (Vietnam) before the impoundment started. It allowed exploration of the natural seismicity in the area of the future dam. Locations of seismic events several months prior to the reservoir impoundment were observed with ten stations installed in the reservoir vicinity. Events were mainly located near the dam along the Da river headwaters fault. However, only four stations were available for the entire period before the impoundment. Despite the network limitations, completeness of seismic catalogue and b value were determined and may be used as a baseline for analysis of the seismicity in this area after impoundment. The magnitude completeness level is significantly smaller than in the broader seismogenic zones covering an area of the dam. The b value differs from the results obtained for regional seismicity of Northeastern Vietnam. The capability of the local network for moment tensor inversion was estimated with the use of synthetic data tests. Test results provided the requirements for the station number according to azimuthal coverage of the network to obtain the reliable full moment tensor (MT) solution. Preliminary analysis of the seismic activity after Lai Chau reservoir impoundment indicates some changes in activity related to the impoundment and reservoir exploitation.
Pyridyl-Ala Modified Cyclic Hexapeptides: In-Vitro and In-Vivo Profiling for Oral Bioavailability
Authors: Vorherr Thomas , Lewis Ian , Berghausen Joerg , Huth Felix , Schaefer Michael , Wille Roman , Gao Jinhai , Wang Bing
Published: October 2019

We and others have been aiming at modifications to maintain or to enhance solubility while enabling permeability for cyclic hexapeptides. Especially, the 2-pyridyl-Ala modification was investigated, since in this case, the pyridyl-nitrogen is able to form an H-bond to the NH of the same residue. The hypothesis of a backbone side-chain interaction was demonstrated by NMR experiments, and further results obtained on a variety of pyridyl-Ala derivatives, studied systematically in the context of permeability, are presented in this contribution. Thus, this study sheds some more light on the pyridyl-Ala modification, which had been reported earlier. In addition to the in vitro profiling, the extent of oral bioavailability was assessed in rats. In principle, the pyridyl-Ala residue can be considered as an amino acid supporting oral uptake.

Graphic Abstract
Expression and analysis of zinc finger family gene in Lenzites gibbosa
Authors: Zhang Jun , Chi Yujie , Li Shuxuan , Zhang Jian , Chen Jie
Published: October 2019

Zinc finger transcription factors play significant roles in the growth and development of plant and animal, but their function remains obscure in fungi.Lenzites gibbosamycelia were extracted and sequenced by transcriptome analysis after growing on sawdust at different times to support mycelial growth ofL. gibbosain a nutrient matrix. Data bases used for analysis were the Kyoto encyclopedia of genes and genomes (KEGG) annotation, the cluster of orthologous groups of proteins (COG) and gene ontology (GO) annotation. Zinc finger class genes related to the growth and development ofL. gibbosawere screened. GO annotation and enrichment analysis of differentially expressed genes were carried out. A total of 114.55 Gb Clean Data were obtained from theL. gibbosatranscriptome. The average Clean Data in each sample was 6.16 Gb. The relative efficiency of reads between each sample and the reference genome was 88.5% to 91.4%. The COG analysis showed that most zinc finger protein genes were related to replication, recombination and repair function. GO enrichment analysis showed that the expressed genes involved in cellular process, cell part and binding. We identified seventy-two expressed genes including seven up-regulated genes and sixty-five down-regulated genes by applying DESeq2 data analysis software. By comparing the significantly expressed genes with KEGG database, 66 annotated sequences were obtained, and 35 primary metabolic pathways were annotated. Pathway enrichment analysis showed that differentially expressed genes were significantly enriched in protein processing in endoplasmic reticulum and ubiquitin-mediated proteolysis pathways. Gene_11750 and gene_5266 are highly correlated with the growth and development ofL. gibbosaand are closely related to protein processing in endoplasmic reticulum and ubiquitin-mediated proteolysis pathway. According to gene functional analysis, seven important differentially expressed genes related to the growth and development ofL. gibbosawere identified.
Molecular Heterogeneity of Papillary Thyroid Cancer: Comparison of Primary Tumors and Synchronous Metastases in Regional Lymph Nodes by Mass Spectrometry Imaging
Authors: Gawin Marta , Kurczyk Agata , Stobiecka Ewa , Frątczak Katarzyna , Polańska Joanna , Pietrowska Monika , Widłak Piotr
Published: October 2019

Intra-tumor heterogeneity results from both genetic heterogeneity of cancer (sub)clones and phenotypic plasticity of cancer cells that could be induced by different local microenvironments. Here, we used mass spectrometry imaging (MSI) to compare molecular profiles of primary tumors located in the thyroid gland and their synchronous metastases in regional lymph nodes to analyze phenotypic heterogeneity in papillary thyroid cancer. Two types of cancerous (primary tumor and metastasis) and two types of not cancerous (thyroid gland and lymph node) regions of interest (ROIs) were delineated in postoperative material from 11 patients, then the distribution of tryptic peptides (spectral components) was analyzed by MSI in all tissue regions. Moreover, tryptic peptides identified by shotgun proteomics in corresponding tissue lysates were matched to components detected by MSI to enable their hypothetical protein annotation. Unsupervised segmentation of all cancer ROIs revealed that different clusters dominated in tumor ROIs and metastasis ROIs. The intra-patient similarity between thyroid and tumor ROIs was higher than the intra-patient similarity between tumor and metastasis ROIs. Moreover, the similarity between tumor and its metastasis from the same patients was lower than similarities among tumors and among metastases from different patients (inter-patient similarity was higher for metastasis ROIs than for tumor ROIs). Components differentiating between tumor and its metastases were annotated as proteins involved in the organization of the cytoskeleton and chromatin, as well as proteins involved in immunity-related functions. We concluded that phenotypical heterogeneity between primary tumor and lymph node metastases from the same patient was higher than inter-tumor heterogeneity between primary tumors from different patients.
The Frontal Bone Window for Transcranial Doppler Ultrasonography in Critically Ill Patients: Validation of a New Approach in the ICU
Authors: Sentenac Pierre , Charbit Jonathan , Maury Camille , Bory Paul , Dagod Geoffrey , Greco Frédéric , Capdevila Xavier , Perrigault Pierre-François
Published: October 2019

Background and Objective

The temporal bone window (TBW) for transcranial Doppler (TCD) often fails to insonate the anterior cerebral artery (ACA). The frontal bone window (FBW) has never been evaluated in intensive care units (ICU). The main objective was to determine the ability of the FBW to assess ACA velocities in critically ill patients.

Methods

A prospective study was conducted in two ICUs of the Montpellier University Hospital (France), between November 2014 and September 2016. Adult patients admitted to ICU for brain injury, with a Glasgow Coma Scale score ≤ 13, were enrolled within 3 days after admission. A first TCD examination was carried out bilaterally through the TBW and FBW by an intensivist expert in TCD, repeated by the same examiner, and 15 min later by an intensivist certified in TCD, designated as non-expert, blinded. The success of the FBW examinations was defined by the ability to measure the ACA velocities. Intra- and interobserver agreements were analyzed according to the Bland and Altman method.

Results

A total of 147 patients were analyzed. The FBW succeeded in insonating the ACA in 66 patients [45%, CI (37–53)], 45 bilaterally and 21 unilaterally. For 16 patients (11%), the FBW was the only way to measure ACA velocities. By combining the two techniques, the ACA success rate increased from 62% CI (54–70) to 73% CI (65–79) (P = 0.05). Intra- and interobserver mean biases and 95% limits of agreement for ACA systolic velocity measurements through the FBW were 1 (− 33 to 35) and 2 (− 34 to 38) cm s−1, respectively. For paired TBW and FBW measures of ACA velocities, mean biases (± SD) for ACA systolic, and mean and diastolic velocities were relatively close to zero, but negatives (− 7 ± 33, − 2 ± 19, − 1 ± 15 cm s−1, respectively), highlighting that ACA velocities were lower with the FBW (A2 segment) than TBW (A1 segment). The correlation coefficient for ACA systolic velocities measured by the FBW and TBW wasR = 0.47, CI (0.28–0.62). No risk factors for failure of the FBW were identified.

Conclusions

In ICU, the FBW was able to insonate the ACA in 45% of patients admitted for brain injury, without the use of contrast agents. The FBW could improve the detection of ACA vasospasms.
Familial Alzheimer’s Disease and Recessive Modifiers
Authors: Vélez Jorge I. , Lopera Francisco , Silva Claudia T. , Villegas Andrés , Espinosa Lady G. , Vidal Oscar M. , Mastronardi Claudio A. , Arcos-Burgos Mauricio
Published: October 2019

Alzheimer’s disease (AD) is progressive brain disorder that affects ~ 50 million people worldwide and has no current effective treatment. AD age of onset (ADAOO) has shown to be critical for the identification of genes that modify the appearance of AD signs and symptoms in a specific population. We clinically characterized and whole-exome genotyped 71 individuals with AD from thePaisagenetic isolate, segregating the (PSEN1) E280A dominant fully penetrant mutation, and analyzed the potential recessive effects of ~ 50,000 common functional genomic variants to the ADAOO. Standard quality control and filtering procedures were applied, and recessive single- and multi-locus linear mixed-effects models were used. We identified genetic variants in theSLC9C1,CSN1S1, andLOXL4acting recessively to delay ADAOO up to ~ 11, ~ 6, and ~ 9 years on average, respectively. In contrast, the CC recessive genotype in markerDHRS4L2-rs2273946 accelerates ADAOO by ~ 8 years. This study, reports new recessive variants modifying ADAOO inPSEN1E280A mutation carriers. This set of genes are implicated in important biological processes and molecular functions commonly affected by genes associated with the etiology of AD such asAPP,APOE, andCLU. Future functional studies using modern techniques such as induced pluripotent stem cells will allow a better understanding of the over expression and down regulation of these recessive modifier variants and hence the pathogenesis of AD. These results are important for prediction of AD and ultimately, substantial to develop new therapeutic strategies for individuals at risk or affected by AD.
Post-mining Remnants and Revitalization
Authors: Kaźmierczak Urszula , Strzałkowski Paweł , Lorenc Marek W. , Szumska Elżbieta , Sánchez Antonio Angel Peréz , Baker Kevin A. C.
Published: October 2019

The historic post-mining objects deserve special attention due to their high cognitive and didactic value. Conducting the revitalization of such facilities is aimed at preserving the mining cultural heritage, and as a result, it will insert attractiveness to the region. The publication attempts to present an approach to the issues of revitalization of post-mining objects and their analysis in Poland, Spain, and UK. In Poland, there is the Revitalization Act, which comprehensively defines stages and ways of conducting revitalization. Spanish legal regulations do not provide for a separate legal act on revitalization, but they are based on mining Law, environmental law, and cultural heritage law. On the other hand, legal regulations in UK do not provide solutions for the revitalization of post-mining areas. However, land leases could incorporate within them, prior to any industrial or mining activities commencement, a requirement for re-stabilization or returning the land to a safe environmental condition on activity completion. Despite the considerable diversity of legal conditions in the described countries, revitalization measures are conducted with positive results, as illustrated by the Gold Mine in Zloty Stok, La Tortilla Mine in Linares, and revitalization of King Edward Mine, an old mining site in Cornwall.
Secretor Status is Associated with Susceptibility to Disease in a Large GII.6 Norovirus Foodborne Outbreak
Authors: Sharma Sumit , Hagbom Marie , Carlsson Beatrice , Nederby Öhd Joanna , Insulander Mona , Eriksson Ronnie , Simonsson Magnus , Widerström Micael , Nordgren Johan
Published: October 2019

Norovirus is commonly associated with food and waterborne outbreaks. Genetic susceptibility to norovirus is largely dependent on presence of histo-blood group antigens (HBGA), specifically ABO, secretor, and Lewis phenotypes. The aim of the study was to determine the association between HBGAs to norovirus susceptibility during a large norovirus foodborne outbreak linked to genotype GII.6 in an office-based company in Stockholm, Sweden, 2015. A two-episode outbreak with symptoms of diarrhea and vomiting occurred in 2015. An online questionnaire was sent to all 1109 employees that had worked during the first outbreak episode. Food and water samples were collected from in-house restaurant and tested for bacterial and viral pathogens. In addition, fecal samples were collected from 8 employees that had diarrhea. To investigate genetic susceptibility during the outbreak, 98 saliva samples were analyzed for ABO, secretor, and Lewis phenotypes using ELISA. A total of 542 of 1109 (49%) employees reported gastrointestinal symptoms. All 8 fecal samples tested positive for GII norovirus, which was also detected in coleslaw collected from the in-house restaurant. Eating at the in-house restaurant was significantly associated with risk of symptom development. Nucleotide sequencing was successful for 5/8 fecal samples and all belonged to the GII.6 genotype. HBGA characterization showed a strong secretor association to norovirus-related symptoms (P = 0.014). No association between norovirus disease and ABO phenotypes was observed. The result of this study shows that non-secretors were significantly less likely to report symptoms in a large foodborne outbreak linked to the emerging GII.6 norovirus strain.
Who Is a Pathologist According to Oncology Patients and Internet Users? A Survey Study
Authors: Kunc Michał , Miszewski Kevin , Bieńkowski Michał , Kamieniecki Alexandra , Ekman Marcin , Gorczyński Adam , Biernat Wojciech
Published: October 2019

The pathologist is frequently called “the doctor’s doctor.” However, there are many uncertainties about the role of a pathologist among patients and policymakers and even among other medical specialties. The aim of the current study is to analyze the misconceptions of who a pathologist is among inpatients and Internet users, to find where the lack of understanding is originating from, and to confirm the need to educate the general public about pathologists. The survey of Internet users was conducted among Facebook users, utilizing the snowball sampling method. Inpatients were randomly recruited in the Department of Surgical Oncology. Seventy-eight inpatients and 320 Internet users were enrolled in the study. Significantly, more hospital patients than Internet users answered that the pathologist is not an MD (p = 0.00953). A portion of participants stated that pathologists do not make diagnoses (n = 28, 7.03%) and do not influence the treatment plan (n = 37, 9.30%) and that the other specialists do not gain anything from the pathologist’s work (n = 67, 16.83%). Only 15.07% of respondents had their information about pathologists from other doctors. The findings from this study should show that even the most basic knowledge of a pathologist being an MD is not known. Pathologists are not recognized for being involved in the diagnosis of diseases. This should provide an incentive to pathologists to teach future doctors, policymakers, and patients about the perplexity of the pathology specialty. It shows obvious gaps in the knowledge of the treatment process as a whole.
Tax efficiency in a model of endogenous markups
Authors: Durceylan Esra
Published: October 2019

Efficiency comparison of ad valorem and unit taxes has been traditionally based on consumer welfare. However, if the tax instrument also affects the distribution of firms over their productivities, the policy maker may be concerned about the implications on aggregate productivity as well. This paper makes an efficiency comparison of ad valorem and unit taxes by allowing the distribution of firms to respond to changes in policy. First, I make an efficiency comparison in a model with monopolistically competitive firms that are homogenous with respect to their productivity levels. Consumer preferences exhibit love for variety and allow firms to adjust their markups. I find that ad valorem tax is more efficient. Allowing for firm heterogeneity overturns this result at high revenue requirements. As the tax rate increases, ad valorem tax causes excessive exit of firms which makes the market more competitive. Hence, few surviving firms price lower by decreasing their markups. Lower prices decrease the tax revenue collected. As a result under ad valorem tax regime, higher consumer surplus is dominated by lower tax revenue. On the other hand, production is concentrated among relatively more productive firms. Thus, aggregate productivity is higher under ad valorem tax regime.
A call for action: integrating climate change into the medical school curriculum
Authors: Finkel Madelon L.
Published: October 2019

None
Evaluation of Nile tilapia in monoculture and polyculture with giant freshwater prawn in biofloc technology system and in recirculation aquaculture system
Authors: Hisano Hamilton , Barbosa Phillipe T. L. , Hayd Liliam A. , Mattioli Cristiano C.
Published: October 2019

Biofloc technology system (BFT), recirculation aquaculture system (RAS) and polyculture promote efficient use of water, area and nutrient recycling, which are essential practices for sustainable aquaculture development. The aim of this study was to evaluate the growth, feed efficiency, biofloc composition and water quality of Nile tilapia Oreochromis niloticus (Linnaeus, 1758) in monoculture and polyculture with giant freshwater prawn Macrobrachium rosenbergii (De Man, 1906) in BFT and RAS, over a period of 30 days. Fish (n = 128; 7.29 ± 0.67 g) were distributed randomly in 16 experimental tanks (8 fish/tank). Prawn (n = 96; 0.50 ± 0.09 g) were allocated in 8 experimental tanks (12 prawn/tank) in a polyculture. The experimental design was completely randomized with four treatments with four replicates each, in a factorial design 2 × 2 (BFT and RAS vs. monoculture and polyculture). The experimental diet (28% of digestible protein; 3100 kcal kg−1 of digestible energy) was used both to fish and prawn in BFT and RAS. There was significant effect (p < 0.01) of the system and the culture for weight gain, apparent feed conversion and protein efficiency ratio. The average weight gain and apparent feed conversion of tilapia in monoculture (30.04 g and 1.39) and in polyculture (36.44 g and 1.27) were superior (p < 0.01) in BFT than in monoculture (23.64 g and 1.74) and in polyculture (24.14 g and 1.61) in RAS. Weight gain and survival of giant freshwater prawn was superior (p < 0.01) in BFT (0.43 g and 87%) compared to RAS (0.26 g and 79%). The data showed that BFT provides better growth performance responses in monoculture for Nile tilapia and in polyculture with giant freshwater prawn compared to RAS.
Static analysis of tall buildings based on Timoshenko beam theory
Authors: Davari Seyed Mozafar , Malekinejad Mohsen , Rahgozar Reza
Published: October 2019

In this paper, the continuum model, which is known as Kwan model, has been presented for the analysis of tall buildings that have been as an appropriate approximation of the overall behavior of the structure. Tall building was modeled as a cantilever beam and analyzed with the assumption of flexural behavior based on Euler–Bernoulli Beam Theory, then the displacement of floors was calculated. o consider the shear lag effects in the overall displacement of the structure, Timoshenko’s beam model has been considered and related relations were extracted. The lateral displacement formulas obtained and calculated for the framed tube system modeled by Kwan’s method. To verify the results, numerical models were created in software (ETABS) and statically were analyzed for lateral loading. Finally the results were compared with those obtained by computer analysis and the corresponding diagrams were presented. At the end, the shape factor formula has been developed to improve the results of the Timoshenko’s theory.
Treatment of metabolic acidosis with sodium bicarbonate delays progression of chronic kidney disease: the UBI Study
Authors:   The UBI Study Group, Di Iorio Biagio R. , Bellasi Antonio , Raphael Kalani L. , Santoro Domenico , Aucella Filippo , Garofano Luciano , Ceccarelli Michele , Di Lullo Luca , Capolongo Giovanna , Di Iorio Mattia , Guastaferro Pasquale , Capasso Giovambattista
Published: October 2019

Background

Metabolic acidosis is associated with accelerated progression of chronic kidney disease (CKD). Whether treatment of metabolic acidosis with sodium bicarbonate improves kidney and patient survival in CKD is unclear.

Methods

We conducted a randomized (ratio 1:1). open-label, controlled trial (NCT number: NCT01640119. www.clinicaltrials.gov) to determine the effect in patients with CKD stage 3–5 of treatment of metabolic acidosis with sodium bicarbonate (SB) on creatinine doubling (primary endpoint), all-cause mortality and time to renal replacement therapy compared to standard care (SC) over 36-months. Parametric, non-parametric tests and survival analyses were used to assess the effect of SB on these outcomes.

Results

A total of 376 and 364 individuals with mean (SD) age 67.8 (14.9) years, creatinine clearance 30 (12) ml/min, and serum bicarbonate 21.5 (2.4) mmol/l were enrolled in SB and SC, respectively. Mean (SD) follow-up was 29.6 (9.8) vs 30.3 (10.7) months in SC and SB. respectively. The mean (SD) daily doses of SB was 1.13 (0.10). 1.12 (0.11). and 1.09 (0.12) mmol/kg*bw/day in the first, second and third year of follow-up, respectively. A total of 87 participants reached the primary endpoint [62 (17.0%) in SC vs 25 (6.6%) in SB, p < 0.001). Similarly, 71 participants [45 (12.3%) in SC and 26 (6.9%) in SB, p = 0.016] started dialysis while 37 participants [25 (6.8%) in SC and 12 (3.1%) in SB, p = 0.004] died. There were no significant effect of SB on blood pressure, total body weight or hospitalizations.

Conclusion

In persons with CKD 3–5 without advanced stages of chronic heart failure, treatment of metabolic acidosis with sodium bicarbonate is safe and improves kidney and patient survival.
Theoretical Error Analysis of Solution for Two-Dimensional Stochastic Volterra Integral Equations by Haar Wavelet
Authors: Fallahpour M. , Khodabin M. , Maleknejad K.
Published: October 2019

The finding an efficient way to the approximate solutions of the stochastic integral equations is an essential requirement. In this paper we discuss the convergence analysis of the two-dimensional Haar wavelet functions (2D-HWFs) method for solve 2D linear stochastic Volterra integral equation. The illustrative examples are included to demonstrate the validity and applicability of this numerical method.
Scoring and classifying regions via multimodal transportation networks
Authors: Bramson Aaron , Hori Megumi , Zha Bingran , Inamoto Hirohisa
Published: October 2019

In order to better understand the role of transportation convenience in location preferences, as well as to uncover transportation system patterns that span multiple modes of transportation, we analyze 500 locations in the Tokyo area using properties of their multimodal transportation networks. Multiple sets of measures are used to cluster regions by their transportation features and to classify them by their synergistic properties and dominant mode of transportation. We use twelve measures collected at five different radii for five distinct combinations of transportation networks to rank locations by their transportation characteristics. We introduce an additional 114 scores derived from the 300 measures to assess, among other things, access to public transportation, the effectiveness of each mode of transportation, and synergies among the modes of transportation. Additionally, we leverage those scores to classify our locations as being train-centric, bus-centric, or car-centric and to uncover geographic patterns in these characteristics. We find that business hubs, despite having low populations, are so conveniently reachable via train and road systems that they consistently achieve the highest sociability and convenience scores. Suburban regions have more serviceable bus systems, but lower connectivity overall resulting in lower reachable populations despite greater local populations. Even though Tokyo has the largest and densest public transportation system in the world we find that the road network consistently dominates the train and bus networks for all accessibility measures.
Inferring network properties based on the epidemic prevalence
Authors: Ma Long , Liu Qiang , Van Mieghem Piet
Published: October 2019

Dynamical processes running on different networks behave differently, which makes the reconstruction of the underlying network from dynamical observations possible. However, to what level of detail the network properties can be determined from incomplete measurements of the dynamical process is still an open question. In this paper, we focus on the problem of inferring the properties of the underlying network from the dynamics of a susceptible-infected-susceptible epidemic and we assume that only a time series of the epidemic prevalence, i.e., the average fraction of infected nodes, is given. We find that some of the network metrics, namely those that are sensitive to the epidemic prevalence, can be roughly inferred if the network type is known. A simulated annealing link-rewiring algorithm, called SARA, is proposed to obtain an optimized network whose prevalence is close to the benchmark. The output of the algorithm is applied to classify the network types.
Mobile phone data reveals the importance of pre-disaster inter-city social ties for recovery after Hurricane Maria
Authors: Yabe Takahiro , Ukkusuri Satish V. , C. Rao P. Suresh
Published: October 2019

Recent disasters have shown the existence of large variance in recovery trajectories across cities that have experienced similar damage levels. Case studies of such events reveal the high complexity of the recovery process of cities, where inter-city dependencies and intra-city coupling of social and physical systems may affect the outcomes in unforeseen ways. Despite the large implications of understanding the recovery processes of cities after disasters for many domains including critical services, disaster management, and public health, little work have been performed to unravel this complexity. Rather, works are limited to analyzing and modeling cities as independent entities, and have largely neglected the effect that inter-city connectivity may have on the recovery of each city. Large scale mobility data (e.g. mobile phone data, social media data) have enabled us to observe human mobility patterns within and across cities with high spatial and temporal granularity. In this paper, we investigate how inter-city dependencies in both physical as well as social forms contribute to the recovery performances of cities after disasters, through a case study of the population recovery patterns of 78 Puerto Rican counties after Hurricane Maria using mobile phone location data. Various network metrics are used to quantify the types of inter-city dependencies that play an important role for effective post-disaster recovery. We find that inter-citysocialconnectivity, which is measured by pre-disaster mobility patterns, is crucial for quicker recovery after Hurricane Maria. More specifically, counties that had more influx and outflux of people prior to the hurricane, were able to recover faster. Our findings highlight the importance of fostering the social connectivity between cities to prepare effectively for future disasters. This paper introduces a new perspective in the community resilience literature, where we take into account the inter-city dependencies in the recovery process rather than analyzing each community as independent entities.
Detecting social media users based on pedestrian networks and neighborhood attributes: an observational study
Authors: Masias Victor H. , Hecking Tobias , Crespo Fernando , Hoppe H. Ulrich
Published: October 2019

This paper proposes a methodological approach to explore the ability to detect social media users based on pedestrian networks and neighborhood attributes. We propose the use of a detection function belonging to the Spatial Capture–Recapture (SCR) which is a powerful analytical approach for detecting and estimating the abundance of biological populations. To test our approach, we created a set of proxy measures for the importance of pedestrian streets as well as neighborhood attributes. The importance of pedestrian streets was measured by centrality indicators. Additionally, proxy measures of neighborhood attributes were created using multivariate analysis of census data. A series of candidate models were tested to determine which attributes are most important for detecting social media users. The results of the analysis provide information on which attributes of the city have promising potential for detecting social media users. Finally, the main results and findings, limitations and extended use of the proposed methodological approach are discussed.
Correction to: An economic analysis of the proposed Dhaka–Chittagong Expressway in Bangladesh with the viewpoint of GHG emission reduction
Authors: Uddin Md. Zia , Mizunoya Takeshi
Published: October 2019

The article An economic analysis of the proposed Dhaka–Chittagong Expressway in Bangladesh with the viewpoint of GHG emission reduction, written by Md. Zia Uddin and Takeshi Mizunoya, was originally published electronically on the publisher’s internet portal  on 26 September 2019 without open access.
Harvesting of autogenous grafts for gingival recession coverage
Authors: Windisch Peter , Molnar Balint
Published: October 2019

The ultimate aim of periodontal plastic surgery is to create optimal pink esthetics through the reconstruction of gingival recessions. Application of autogenous soft tissue grafts is considered as a gold standard treatment modality with predictable esthetic outcomes for gingival recession coverage. Harvesting a free soft tissue graft from an esthetically irrelevant region of the oral mucosa using various techniques can prevent donor site complications around the adjacent teeth.
The New Politics of Religious Education in the United States and Germany
Authors: Barb Amandine
Published: October 2019

This Article explores the contemporary governance of religious diversity in the United States and Germany through the case study of religious education in public schools. The United States and Germany have two very different approaches to teaching religion: The subject does not exist at all in American public schools, while in Germany, confessional religious education is explicitly mandated by the Federal Constitution and is still an integral part of the curriculum in the vast majority of Länder. Yet, both countries have recently been confronted with similar challenges—a growing diversification and politicization of religious identities—which have forced them to rethink the place and role traditionally given to faith in the sphere of public education. The Article thus examines how, and to what extent, the American and German historical models of religious education—and thereby, more broadly, the public governance of religion in both countries—have been transformed by the changes in their religio-political landscapes.
Origin of the Fule Pb–Zn deposit, Yunnan Province, SW China: insight from in situ S isotope analysis by NanoSIMS
Authors: Li Zhenli , Ye Lin , Hu Yusi , Huang Zhilong , Wei Chen , Wu Tao
Published: October 2019

The Sichuan–Yunnan–Guizhou (SYG) Pb–Zn metallogenic province is one of the most productive areas of Pb–Zn resources in China. The Fule deposit occurs in Permian carbonate and contains Pb–Zn reserves exceeding 1 Mt. To investigate the sulphur source, in situ S isotopic analysis of sphalerite and pyrite was carried out using nanoscale secondary-ion mass spectrometry. The results show that the δ34S values of the sulphide minerals range from +16.1‰ to +23.0‰, higher than that of marine sulphates hosted in Permian carbonate rocks (+11‰), but similar to that of sulphates over a broader area (+12.9‰ to +25.9‰). The sulphates in the regional rocks could therefore represent an important source of S for the Fule deposit via thermochemical sulphate reduction. The S source of the Fule deposit is different from those of most other Pb–Zn deposits in the SYG Pb–Zn mineralization province, which were mainly derived from the ore-bearing strata. The δ34S values of the early to late generations and some single sulphide crystals from the cores to rims show a slight increasing trend, implying that partial Rayleigh fractionation took place in the Fule deposit. It is suggested that the Fule sulphide precipitation resulted from the mixing of a metalliferous fluid with a H2S-rich fluid derived from the regional strata. Combining the geology, mineralogy and S isotope results with previous Pb isotope studies, it is suggested that the Fule deposit should be attributed to a Mississippi Valley type deposit.
More Cash, Less Innovation: The Effect of the American Jobs Creation Act on Patent Value
Authors: Almeida Heitor , Hsu Po-Hsuan , Li Dongmei , Tseng Kevin
Published: October 2019

Firms can become less innovative following a sudden cash “inflow.” Specifically, multinational firms that were eligible to repatriate (and indeed repatriated) cash to the United States under the American Jobs Creation Act (AJCA) generate less valuable patents than otherwise similar firms. They also explore more. This effect only exists among firms in less competitive industries, firms with lower institutional ownership (IO), and firms with overconfident chief executive officers (CEOs); this effect is mainly driven by the reduction in the value of U.S.-originated patents. Our evidence suggests that, without appropriate governance, a cash windfall may lead managers to engage in riskier innovation strategy, which can destroy value.
Are wolves welcome? Hunters' attitudes towards wolves in Vermont, USA
Authors: Grima Nelson , Brainard John , Fisher Brendan
Published: October 2019

The forests of the north-east USA were once home to the wolfCanis lupus, a species that played an important role in the ecology of this region. However, wolves were eradicated from the region more than a century ago, altering the species composition of the landscape and driving cascading changes in this ecosystem. Outdoor recreation is a major component of the economy of this region, and outdoor recreationists, including the hunting community, have a strong influence over decision-making related to policies on natural resources. Given their powerful position, hunters are important stakeholders whose views need to be taken into account when designing policies related to wildlife, in particular in relation to a controversial species such as the wolf. In this study, through expert interviews and an online survey, we gained a deeper understanding of the attitudes of hunters towards wolves, and how these attitudes could affect any future reintroduction programme or natural movement of wolves into the state. We found that the majority of hunters hold a suite of negative attitudes towards wolves, their role in the landscape and their potential impact on the region. However, for hunters who were able to recognize the ecological roles of wolves, these negative attitudes were mostly reversed.
Collective memory of the Kirkenes iron mine in sub-Arctic Norway: Its role in forming the future
Authors: Wråkberg Urban
Published: October 2019

This study argues that collective memory is a relevant concept that can be used to analyse how the outlooks on industrial futures are shaped in remote northern locations. The case in question is the Sydvaranger iron mine in Kirkenes in the north-easternmost part of Norway. By drawing attention to the long periods of time often involved in forming collective memory, this study questions the viability of top-down processes of forming opinions aiming to set local minds on the track towards either “place-renewal” into an unknown post-industrial future or towards attaining a “social licence to operate” for any new or continued raw material producing industry. This exploration includes a discussion of memory studies, an overview of the industrial history of Kirkenes as part of a Euroarctic borderland and a study of the manifestations of collective memory in the contemporary local media. Revealing insights were obtained in Kirkenes through informal conversations and participant observation.
Empirically defining treatment response and remission in body dysmorphic disorder
Authors: Fernández de la Cruz Lorena , Enander Jesper , Rück Christian , Wilhelm Sabine , Phillips Katharine A. , Steketee Gail , Sarvode Mothi Suraj , Krebs Georgina , Bowyer Laura , Monzani Benedetta , Veale David , Mataix-Cols David
Published: October 2019

Background

The number of clinical trials in body dysmorphic disorder (BDD) has steadily increased in recent years. As the number of studies grows, it is important to define the most empirically useful definitions for response and remission in order to enhance field-wide consistency and comparisons of treatment outcomes across studies. In this study, we aim to operationally define treatment response and remission in BDD.

Method

We pooled data from three randomized controlled trials of cognitive-behavior therapy (CBT) for BDD (combined n = 153) conducted at four academic sites in Sweden, the USA, and England. Using signal detection methods, we examined the Yale-Brown Obsessive Compulsive Scale modified for BDD (BDD–YBOCS) score that most reliably identified patients who responded to CBT and those who achieved remission from BDD symptoms at the end of treatment.

Results

A BDD–YBOCS reduction ⩾30% was most predictive of treatment response as defined by the Clinical Global Impression (CGI) – Improvement scale (sensitivity 0.89, specificity 0.91, 91% correctly classified). At post-treatment, a BDD–YBOCS score ⩽16 was the best predictor of full or partial symptom remission (sensitivity 0.85, specificity 0.99, 97% correctly classified), defined by the CGI – Severity scale.

Conclusion

Based on these results, we propose conceptual and operational definitions of response and full or partial remission in BDD. A consensus regarding these constructs will improve the interpretation and comparison of future clinical trials, as well as improve communication among researchers, clinicians, and patients. Further research is needed, especially regarding definitions of full remission, recovery, and relapse.
On stage one of Feser's ‘Aristotelian proof’
Authors: OPPY GRAHAM
Published: October 2019

This article is a response to Ed Feser's claim that his ‘Aristotelian proof’ establishes that atheists have no part in ‘the real debate’. I argue that Feser (2017) nowhere establishes that Premises 4 and 7 in his ‘Aristotelian proof’ are anything more than claims about which he and his opponents – including atheists like me – disagree. In particular, I suggest that it is neither mysterious nor surprising that, by their own lights, atheists have more than sufficient reason to reject premises 4 and 7. Given this, it is clear that Feser's ‘Aristotelian proof’ is not able to do what Feser claims that it does.

Feser (2017) presents and defends five proofs of the existence of God. Each proof is in two stages: the first stage proves the existence of something which, in the second stage, is shown to possess an appropriate range of divine attributes. Each proof is given two presentations, one informal and one formal. Here, I propose to discuss just the first stage of one of Feser's five proofs. In particular, I propose to focus on just two of the premises in the chosen first stage proof.
Self-Reflexivity as a form of Client Participation: Clients as Citizens, Consumers, Partners or Self-Entrepreneurs
Authors: MONRAD MERETE
Published: October 2019

The article suggests that self-reflexive participation should be considered a distinct form of client participation. Self-reflexive participation is an individualized form of participation that occurs through a development-oriented dialogue between the client and a practitioner. In this dialogue, clients reflect on themselves, set goals for the future and devise strategies, thereby improving their self-regulatory potentials. The article discusses important differences between self-reflexive participation and democratic, consumerist and co-productive participation in terms of the form participation takes, the aim of participation, the client role, the resources required from clients to participate, the assumed relationship between the agency and the client and organizational responsiveness. Self-reflexive participation is based on a view of the client as capable and reflexive and it may foster a tailoring of social services to the wishes and life-projects of clients. However, self-reflexive participation is based on the assumption that clients can be empowered through improved skills of self-observation and life-planning. When focus is on these skills, it may gloss over important conflicts between clients and agency and detach questions of client participation from organizational responsiveness and struggles over user control.
A multi-dimensional perspective on the gender gap in health among older adults in India and China: application of a new ageing measure
Authors: Balachandran Arun , James K. S.
Published: October 2019

A continuous rise of female life expectancy above that of males among older adults in India and China may give the impression that the relative gender gap in health in these countries is decreasing. However, given the systemic gender bias against older females in these countries across multiple dimensions of health, a fuller understanding of the gender gap in health calls for a multi-dimensional perspective. We estimate a multi-dimensional old-age threshold (MOAT) that specifies different old-age thresholds for female and male populations which accommodates multiple dimensions related to physical, intellectual and general health. We use the MOAT to evaluate the multi-dimensional gender gap in India and China by differencing the MOAT for females with that of males. Females in both countries have a lower MOAT than their male counterparts, indicating an earlier advent of ‘old age’ for females. The multi-dimensional estimates of the gender gap are also higher than the estimates based on only one dimension of health. A considerable level of variation is also observed in the gender gap across provinces. The study illustrates the need to understand the gender gap in health in India and China from a multi-dimensional perspective and provides an innovative way to quantify such a gap. Province-specific as well as health dimension-specific interventions are vital in reducing the gender gap among older adults in these countries.
Pathways from Farmers to States around the Globe
Authors: Drennan Robert D.
Published: October 2019

InAgainst the Grain, James Scott has produced an admirably broad and sweeping account of state origins. He takes humans’ first use of fire as his starting point and works his way toward states by way of the transition to settled agricultural life in the Neolithic. The intended audience would seem to be primarily the general public, for whom Scott's goals are ‘condensing the best knowledge we have … and then suggesting what it implies’ (p. xii). It is clearly, however, an audience more professionally concerned with state origins that he has in mind when he says ‘…these implications … are meant to be provocations … intended to stimulate further reflection and research’ (p. xiii), and his book provides plenty of fuel for such stimulation.