bluuebunny/crossref_metadata_2025 huggingface dataset:
The extraordinary boundary transition in the 3d O(N) model via conformal bootstrap
Authors: Padayasi Jaychandran , Krishnan Abijith , Metlitski Max , Gruzberg Ilya , Meineri Marco
Published: June 2022

This paper studies the critical behavior of the 3d classical
O(N)(N)
model with a boundary. Recently, one of us established that upon
treating NN
as a continuous variable, there exists a critical value
N_c > 2Nc>2
such that for 2 \leq N < N_c2≤N<Nc
the model exhibits a new extraordinary-log boundary universality class,
if the symmetry preserving interactions on the boundary are enhanced.
N_cNc
is determined by a ratio of universal amplitudes in the normal
universality class, where instead a symmetry breaking field is applied
on the boundary. We study the normal universality class using the
numerical conformal bootstrap. We find truncated solutions to the
crossing equation that indicate N_c \approx 5Nc≈5.
Additionally, we use semi-definite programming to place rigorous bounds
on the boundary CFT data of interest to conclude that
N_c > 3Nc>3,
under a certain positivity assumption which we check in various
perturbative limits.
Reabilitação oral em pacientes bruxistas: uma revisão de literatura
Authors: Maria Patrícia Rogério de Mendonça  , Ivo de Souza Albuquerque  , Raimunda Priscila Rogério de Mendonça
Published: June 2022

O bruxismo cêntrico é uma atividade parafuncional da musculatura da mastigação, caracterizado por ranger e/ou apertamento dentário. Pode ser diurno ou noturno, com causas multifatoriais e sem tratamento específico. Essa estereotipia mandibular dificulta a reabilitação protética e requer experiência profissional. Objetivo: Verificar, na bibliografia da área, a efetividade dos diferentes tipos de próteses dentárias em pacientes bruxistas. Revisão de literatura: Trata-se de uma revisão de literatura integrativa realizada nas bases de dados PubMed, Web of Science, Scielo, Lilacs e Medline, nos idiomas inglês, português e espanhol, com publicações de novembro de 2009- 2019. Resultados: Dos 16 artigos encontrados, nove (56,25%) são relato de caso clínico, nove (56,25%) com bruxismo noturno, em quatro (25%) a overlay restabelecia a dimensão vertical de oclusão (DVO), em dez (62,5%) houve uso de placa miorrelaxante e cinco (31,25%) relataram próteses antigas com danos estruturais. Conclusão: São necessários mais estudos clínicos e com maior número de pacientes para avaliar o desempenho de diferentes tipos de materiais com os quais são confeccionadas as próteses dentárias, a efetividade do restabelecimento da DVO e os tipos de falhas estruturais que mais acometem as próteses dentárias nos pacientes bruxistas.
Considerações sistêmicas sobre o enxerto de biomaterial bovino na Odontologia – relato de caso
Authors: Thiago Dal Santo Neves  , Thiago Henrique Mendonça Rocha Tosta  , Jeferson Luis de Oliveira Stroparo  , Amanda Kiyomi Rossi  , Tatiana Miranda Deliberador  , João César Zielak
Published: June 2022

Visando garantir reabilitação dentária por implantes, o uso de enxertos ósseos possibilita tomada de decisões e alternativas de tratamentos. Esse enxerto pode ser classificado como autógeno, alógeno, xenógeno e aloplástico; cada um deles possui suas características, indicações, vantagens e desvantagens. Por isso, faz-se imprescindível o entendimento específico de cada uma das opções e suas indicações, para o melhor resultado da reabilitação. Objetivo: Observando todos esses aspectos, fica clara a necessidade de discussão sobre um material completo que possua todas as características osteoindutoras, osteocondutoras, sucesso clínico e, acima de tudo, compatibilidade biológica. Relato de caso: Neste relato, um caso de enxerto bilateral de seio maxilar é apresentado, abordando-se os usos do enxerto ósseo xenógeno, relacionando sua aplicação clínica à ativação do sistema imunológico, doações de sangue e transplantes. Resultados: Apesar dos resultados positivos e das inúmeras pesquisas a respeito dos enxertos xenogênicos, aponta-se para a importância do comprometimento sistêmico relacionado ao uso desses biomateriais. Conclusão: Alternativas de enxertia óssea devem ser discutidas com o paciente, sendo fundamental que ele seja devidamente informado sobre vantagens e desvantagens dos enxertos. Também torna-se clara a necessidade de mais pesquisas sobre os biomateriais sintéticos, a fim de garantir a previsibilidade nos resultados clínicos.
Conformations of Model Peptides With 1-Aminocycloalkane-1-Carboxylic Acid Residues
Authors: Rao Shashidhar N. , Ramnarayan K. , Chan Ming Fai , Balaji V.  N.
Published: June 2022

We present conformational energy calculations on model compounds contammg 1-amino­ cycloalkane carboxylic acid with 5- (Acc5 )and 6- (Acc6) membered rings using molecular mechanics methods. The low energy models adopt conformations characteristic of ex-helix and polyproline-II-type three- and four-fold helices. The energetically most favored models adopt the α /3 10-helical conformation of either handedness in these compounds. The salient features of our investigations are qualitatively consistent with the crystal structures of peptide analogs containing Acc5 and Acc6 and previously reported solution phase and conformational studies on peptides containing Acc5 .Our results have implications for the design of α /310-helical peptidomimetics.
Sequence Dependent Conformational Motion of a Peptide in the HLA-A2 Binding Groove
Authors: Meng Wilson S. , Gallaher Timothy K. , Grafenstein Hermann von , Haworth Ian S.
Published: June 2022

Using a simulated annealing/molecular dynamics approach. we were able to reproduce the x-ray
crystallographic conformation of the peptide GILGFVFTL when bound to the class I MHC molecule HLA-A2, starting from the backbone conformation of a second peptide TLTSCNTSV obtained from crystallographic data. Observations made during this work led us to a hypothesis of the possible hierarchy of non-covalent interactions that cause GILGFVFTL to adopt its conformation in the HLA-A2 peptide binding groove.
H, 13C, and 15N Assignments for the Ca2+-Bound from of Oncomodulin, A β-Parvalbumin
Authors: Henzl Michael T. , Likos John J. , Hutton William C.
Published: June 2022

quence-specific I H, I 5N, and 13c assignments are reported for the mammalian -parvalbuinin oncomodulin. ae secondary structure deduced from NOE and chemical shift data is similar to that described previously by Ldilla et al. for the pike a isoform (pi 5.0) [1. Mol. Biol. 204: 995-1017]. However, chemical shi.ft analysis ggests that the the two isoforms differ conformationally in the non-functional AB domain. This putative
fference could contribute to the attenuated affinity for Ca2+ and Mg2+ displayed by oncomodulin.
An Overview of the Neuropharmacological Potential of Thymoquinone and its
Targeted Delivery Prospects for CNS Disorder
Authors: Verma Rishabh , Sartaj Ali , Qizilbash Farheen Fatima , Ghoneim Mohammed M. , Alshehri Sultan , Imam Syed Sarim , Kala Chandra , Alam Md. Shamsher , Gilani Sadaf Jamal , Taleuzzaman Mohamad
Published: June 2022

At present, people and patients worldwide are relying on the medicinal plant as a therapeutic agent over
pharmaceuticals because the medicinal plant is considered safer, especially for chronic disorders. Several medicinal
plants and their components are being researched and explored for their possible therapeutic contribution to CNS
disorders. Thymoquinone (TQ) is one such molecule. Thymoquinone, one of the constituents of Plant Nigella Sativa,
is effective against several neurodegenerative diseases like, Alzheimer's, Depression, Encephalomyelitis, Epilepsy,
Ischemia, Parkinson's, and Traumatic. This review article presents the neuropharmacological potential of TQ's, their
challenges, and delivery prospects, explicitly focusing on neurological disorders along with their chemistry, pharmacokinetics,
and toxicity. Since TQ has some pharmacokinetic challenges, scientists have focused on novel formulations
and delivery systems to enhance bioavailability and ultimately increase its therapeutic value. In the present
work, the role of nanotechnology in neurodegenerative disease and how it improves the bioavailability and delivery
of a drug to the site of action has been discussed. There are a few limitations to developing novel drug formulations,
including solubility, pH, and compatibility of nanomaterials. Since here we are targeting CNS disorders, the bloodbrain
barrier (BBB) becomes an additional challenge.
Hence, the review summarized the novel aspects of delivery and biocompatible nanoparticles-based approaches for
targeted drug delivery into CNS, enhancing TQ bioavailability and its neurotherapeutic effects.
Short-term Neuropsychiatric and Body Weight Changes in Patients
Switching From EVG/Cobi/FTC/TAF to BIC/FTC/TAF (PreEC/RIS69)
Authors: Tiraboschi Juan , Prieto Paula , Saumoy Maria , Silva Ana , Imaz Arkaitz , Scevola Sofía , Fernandez Guillem , Navarro Antonio , Piatti Camila , Podzamczer Daniel
Published: June 2022

Background:

We report NP, clinical and laboratory changes in patients switching from
EVG/Cobi/FTC/TAF to BIC/FTC/TAF in clinical practice.

Methods:

A group of subjects switching from EVG/Cobi/FTC/TAF to BIC/F/TAF was prospectively
followed. A validated sleep quality questionnaire (Pittsburgh Sleep Quality Index), as well as the
Hospital Anxiety and Depression Scale (HADS), were administered after 4 weeks from the treatment
switch. Adverse events, side effects and discontinuation were recorded at weeks 4 and 24. Pretreatment
switch and week 24 body weight and laboratory data were compared.

Results:

A total of 96 virologically suppressed patients (86% male) were included. All patients received
EVG/Cobi/FTC/TAF at least 1 year before the treatment switch. Median (IQR) nadir CD4
was 367 (263). The most common comorbidities were dyslipidemia, HTA and diabetes, 26%, 14%
and 7%, respectively. Depression was reported by 8%. Five patients discontinued BIC/FTC/TAF
before week 4 due to intolerance (2 insomnia, 1 headache and 2 GI symptoms). No changes in sleep
quality, anxiety and depression outcomes were observed at week 4 (p = 0.1, p = 0.1 and p = 0.3, respectively).
After 6 months, the median body weight change was statistically significant (0.6 kg,
p = 0.003). All patients maintained HIV suppression.

Conclusions:

Except in a few cases, sleep quality, anxiety and depression symptoms remain stable in
HIV virologically suppressed patients on EVG/Cobi/FTC/TAF who switch to BIC/F/TAF. NPAEs
are mild and tend to occur in those with previous neuropsychiatric symptoms. Weight gain tends to
be small but statistically significant. Long-term follow-up in “real-life” cohorts would be needed to
confirm these findings.
Gender Preference in Gynecology and Obstetrics (GPGO) Scale
Authors: Hage Said El , Daaboul Michael , Sayde Georgio , Ismail Omar , Jamaleddine Youssef , Hallit Souheil , Salameh Pascale
Published: June 2022

Background:

Patients' preferences towards their physicians constitute a crucial part of providing patient-centered care. Gender preference of patients towards gynecologists/obstetricians is controversial.

Objective:

Authors aimed to develop and validate a scale that specifically assesses gender preferences of patients towards physicians in the obstetrics and gynecology field.

Materials and Methods:

Epidemiological cross-sectional study in Lebanon conducted on 1192 participants. Questionnaire used consist of two parts: the first part sociodemographic questions and obstetrics and gynecology specialists overview and the second part was divided into males' and females' perceptions towards gynecologists. The new developed GPGO scale, consisting of 13 items, was only intended for females. Statistical analysis was performed to test the internal reliability, convergent validity, and construct validity.
Overall, there were 1192 responses, 890 females and 302 males. In this study, we only included females’ responses.

Results:

Tests of assumptions of sample adequacy showed communalities higher than 0.3. Factor analysis of the 13 items in the GPGO scale revealed two main components. Items adequately loaded into its component. The scale’s Cronbach alpha, indicating internal reliability, revealed good reliability (0.861). Component 1 had acceptable internal reliability (Cronbach alpha= 0.745). Component 2 had high internal reliability (Cronbach alpha= 0.846). Pearson correlation coefficients were 0.877 (p<0.0001) and 0.898 (p<0.0001), respectively. Therefore, the scale shows adequate convergent validity.

Conclusion:

The resulting GPGO scale, that assesses the preference of patients towards gynecologists and obstetricians, is validated for use in females aged 18 years old and higher. The scale can be used in future studies for comparison or prospective follow-up.
Imputability of Azathioprine in the Occurrence of Chronic Myeloid Leukemia
in Crohn's Disease: An Exceptional Case Report
Authors: Zaimi Yosra , Bouksir Chayma , Ayadi Shema , Ayari Myriam , Ksontini Feryal Letaief
Published: June 2022

Background:

Background: Patients with Cohn’s disease (CD) treated with thiopurines are at an increased risk of developing cancer. Leukemias are less frequent than other hematopoietic tumors and development of Chronic myeloid leukemia (CML) after immunosuppression has not been proven.

Case Report:

We describe the case of a 61-year-old female who developed a CML after 8 years of treatment with azathioprine (AZA) for ileal Crohn’s disease associated to a duodenal localization. We reviewed the current evidence on the interactions between CD, CML and AZA as well as the potential underlying mechanisms of leukemia in AZA-treated patients.

Conclusion:

We concluded that the pathogenesis of CML is multifactorial in CD. The nature of the association between AZA and CML in CD patients warrants further investigation.
Pleural Effusion Induced by Systemic Consumption of Topical Minoxidil:
A Rare Case Report
Authors: Tanguturi Yella Sri Hari , Kumar Kistigari Satyanarayana Pramod , Tanguturi Yella Sree Sudha , Kuotsu Ruuzeno , Krishna Sasanka Kota Sesha Brahma Sree , Thangaraju Pugazhenthan
Published: June 2022

Introduction:

Pleural effusions can be caused by several conditions such as cancer, connective tissue disease, and infection. They are occasionally caused due to the drug as an adverse reaction. Most commonly systemic minoxidil use can cause pleural effusions in patients with chronic kidney disease.

Case presentation:

We present a case of a patient without chronic kidney disease who developed pleural effusion as a result of unintentional use of topical minoxidil orally. The patient's oxygen saturation was 90% on room air, there was dullness to percussion and asymmetrical chest expansion with diminished air entry on both sides. In chest x-ray there was bilateral pleural opacities. In ultrasonography of the chest, it was showed minimal pleural effusions. The patient was managed with diuretics and airway management which resolved completely.

Conclusion:

Minoxidil is a commonly used drug by many people for the treatment of hair fall with or without doctor advice. We would like to stress that even though rare, physicians/pulmonologists should be aware of its rare side effects of topical minoxidil, and it should be kept in mind as a differential diagnosis for pleural effusion.
Cancer Cell De-Differentiation: Plasticity-Driven Stratagem For Tumor
Metastasis and Recurrence
Authors: EL Marsafy Sanaa , Larghero Jérôme
Published: June 2022

Tumor recurrence is a colossal challenge in clinical oncology. This multifactorial problem is
attributed to the emergence of additional genetic mutations and the presence of dormant cancer cells.
However, the plasticity of non-stem cancer cells and the acquisition of cancer stem cell (CSC) functionality
is another contributing factor to tumor recurrence. Herein, I focus attention on the mechanisms that
fuel cancer cell de-differentiation and the interplay between intra-cellular regulators and tumor microenvironment
(TME) landscape that promotes cancer cell stemness. Our understanding of the mechanisms
underlying tumor cell de-differentiation is crucial for developing innovative therapeutic strategies that
prevent cancer from ever recurring.
Calotropis Procera Induced Caspase-Dependent Apoptosis and Impaired Akt/mTOR
Signaling in 4T1 Breast Cancer Cells
Authors: Rabelo Ana Carolina Silveira , Miglino Maria Angélica , Arbizu Shirley , Carreira Ana Cláudia O. , Filho Antônio José Cantanhede , Carneiro Fernando José Costa , Layosa Marjorie Anne A. , Noratto Giuliana
Published: June 2022

Introduction:

Calotropis procera (Aiton) Dryand (Apocynaceae) is an herb that has been commonly used in
folk medicine to treat various diseases for more than 1500 years.

Aims:

Our goal was to investigate the anti-metastatic effects of phenolics extracted from C. procera (CphE) against
4T1 breast cancer cells and in BALB/c mice.

Methods:

4T1 cells were treated with CphE and quercetin (positive control) at concentrations that inhibited cell viability
by 50% (IC50). Levels of reactive oxygen species (ROS), wound healing, and protein expressions were determined
following standard protocols. For the in vivo pilot study, the syngeneic BALB/c mouse model was used. 4T1 cells were
injected into mammary fat pads. Tumors were allowed to grow for 9 days before gavage treatment with CphE (150 mg
GAE/kg/day) or PBS (controls) for one week. Excised tumors, liver, and lungs were analyzed for gene and protein
expression and histology.

Results:

In vitro results showed that CphE suppressed cell viability through apoptosis induction, via caspase-3 cleavage
and total PARP reduction. CphE also scavenged ROS and suppressed Akt, mTOR, ERK1/2, CREB, and Src activation
contributing to cell motility inhibition. CphE reduced IR, PTEN, TSC2, p70S6, and RPS6, protein levels, which
are proteins involved in the PI3K/Akt/mTOR pathway, suggesting this pathway as CphE primary target. In vivo results
showed downregulation of ERK1/2 activation by phosphorylation in tumor tissues, accompanied by angiogenesis
reduction in tumor and lung tissues. A reduction of Cenpf mRNA levels in liver and lung tissues strongly suggested
anti-invasive cancer activity of CphE.

Conclusion:

CphE inhibited 4T1 cell signal pathways that play a key role in cell growth and invasion. The potential
for in vitro results to be translated in vivo was confirmed. A complete animal study is a guarantee to confirm the CphE
anticancer and antimetastatic activity in vivo.
Risk Perception and Crash Involvement of Cell Phone Users While Driving Among Young Drivers in Developing Countries: The Case of Qatar
Authors: Shaaban Khaled , Gargoum Suliman , El-Basyouny Karim
Published: June 2022

Background:

Cell phone use while driving is a significant safety problem all around the world. It is considered one of the main factors contributing to road crashes among young drivers.

Aim:

To address this problem, it is important to determine how young drivers perceive the risk of using a cell phone while driving and to understand whether the perception of risk is correlated with their crash involvement.

Methods:

Data were collected through a detailed questionnaire from young drivers in Qatar to assess potential correlations between the drivers’ demographic background, perception of risk, and crash involvement. Logistic regression models were developed to explore the relationships between those variables.

Results:

The analysis revealed that female drivers had a higher perception of risk related to using cell phones while driving compared to male drivers. Drivers with higher education levels were found to also have a higher perception of risk when compared to less educated drivers. The analysis showed that participants who perceived lower risk of answering a call while driving were more likely to be involved in a crash.

Conclusion:

These results can be useful to identify the groups that should be targeted through countermeasures. Different countermeasures were presented, and directions for future research were proposed.
Optimizing and Evaluating the Transdermal Permeation of Hydrocortisone
Transfersomes Formulation Based on Digital Analysis of the In Vitro
Drug Release and Ex Vivo Studies
Authors: Abdelwahd Asmae , Abdul Rasool Bazigha K.
Published: June 2022

Background:

Transfersomes can be used to enhance transdermal drug delivery due to their
flexibility and ability to incorporate various molecules. For example, hydrocortisone (HC), a corticosteroid,
is taken by different routes and serves as immunosuppressive, anticancer, and antiallergenic;
however, it is poorly absorbed by the skin.

Objective:

Therefore, the current study suggested HC-loaded transfersomes as an alternative route of
administration for reaching deeper skin layers or systemic circulation, to reduce the side effects of HC
and improve its bioavailability.

Methods:

HC transfersomes were prepared by the thin-film hydration method and characterized for their
vesicular size, zeta potential, drug entrapment efficiency, elasticity, FTIR spectroscopy, in vitro drug release,
ex vivo permeation, and irritancy in rabbits. The optimized formulation, F15 (containing HC 20
mg, egg phosphatidylcholine (EPC) 400 mg, and 75 mg of Span 80), was chosen because it showed the
highest (p< 0.05) EE% (60.4±0.80) and optimized sustained in vitro drug release (Q8 = 87.9±0.6%).

Results:

Extensive analysis of the drug release data from all formulas was performed using the DDSolver
software which quantitatively confirmed the successful formulation. The Weibull equation was the best
model to fit the release data compared to others, and the release mechanism was Fickian diffusion.

Conclusion:

The simulated pharmacokinetic parameters showed that F15 had the highest AUC, MDT,
and DE. Furthermore, F15 significantly enhanced HC permeation by 12-folds compared to the control
through the excised rat's skin. The skin irritancy test has proven F15 safety and skin compatibility.
Plant Secondary Metabolites in Halophytes
Authors: Attia-Ismail Salah Abdelaty
Published: June 2022

Plant secondary metabolites (PSMs) are the intermediate or end products of
the primary metabolism of higher plants and are not involved in metabolic activities.
Primary metabolites are the compounds that are indispensable in the processes of
photosynthesis, respiration, and growth and development. To a certain degree, these
compounds are found in all plants, yet they are common in tropical forages. In spite of
the high cost of energy for the biosynthesis of PSMs, they are produced for protective
purposes. Most halophytic plant species produce secondary metabolites with wide
biological activity, such as tannins, organic acids, carotene, ascorbic acid, glycosides,
absinthin, and essential oils. This chapter discusses the occurrence of PSM's in
halophytes, the origin and divisions of plant secondary metabolites, and the distribution
of PSM's in plant species and organs.
Maximizing The Utilization Of Halophytes As Feed For Animals
Authors: Attia-Ismail Salah Abdelaty
Published: June 2022

The greater demand for feed in most developing countries imposes certain
pressures. Therefore, the use of non conventional feed resources is gaining a rising
significance. Halophytes can, then, play an important role in the well being of different
peoples. This chapter discusses the constraints of feeding halophytes, consequences of
feeding halophytes to animals, methods and strategies to maximize utilization of
halophytes (breeding halophytes, overcoming the effects of plant secondary
metabolites, overcoming the effects of high salt contents, treatment of halophytes prior
to feeding (mechanical treatments, drying, haylage, ensiling, pelleting and feed cubes
or blocks, biological treatments, feed additives and supplements)).
Halophytic Plants for Animal Feed: Associated Botanical and Nutritional Characteristics
Authors: Attia-Ismail Salah Abdelaty
Published: June 2022

Halophytic plants are a fascinating group of plants that also serve as dietary feed for livestock. Their utilization is essential for sustainable agriculture and maintaining ecological balance. This book explains the nature of halophytic plants through an in-depth presentation of their botanical and nutritional characteristics. Chapters of the book highlight different aspects of halophytes on a botanical, histological, ecological and nutritional basis when utilized as animal feed components. The issues of the histo-chemical aspects of halophytes are addressed with regard to their impact on nutrient compositions and availability to animals, while the important nutrient contents of halophytes are considered in relation to their value to animals.

Key Features:

- 10 organized chapters on halophytic plants

- Explains the relationship between botanical and nutritional characteristics of halophytes when utilized as animal feed components

- Covers information about important nutrient contents and secondary metabolites in halophytes

- Includes information on nutritional and feeding values for animals

- Includes informative diagram and tables

- Includes references for further reading

This book fills a notable gap in available literature on the subject, and will stimulate researchers to pursue the many unanswered questions in the field of biosaline agriculture. This text serves as reading material for undergraduate and graduate level courses and specializations in agriculture, animal nutrition, animal physiology, botany and plant physiology. It also serves as supplementary reading for students of taxonomy, ecology, and environmental science courses. Professional and apprentice livestock farmers will also benefit from the information presented by the book.
Eucharistic Hospitality in Ecumenical Contexts: Learning from Monastic Experiences
Authors: Wouda Fokke
Published: June 2022

This practical theological study explores Eucharistic hospitality in the ecumenical monastic communities of Taizé, (Burgundy, France) and (Piedmont, Italy). Tracing the theology embedded in this practice, it offers empirically grounded insights into the dynamics of the Eucharistic hospitality and provides an innovative view on the sensus fidei on this point. As such, this study presents a relevant addition to the charged debate about this sensitive issue, challenging Roman Catholic theology to learn from the decades-long experience accumulated in the communities.
Exploring Urological Malignancies on Pinterest: Content Analysis
Authors: Herbert Amber S , Hassan Naeemul , Malik Rena D , Loeb Stacy , Myrie Akya
Published: June 2022

Background

Pinterest is a visually oriented social media platform with over 250 million monthly users. Previous studies have found misinformative content on genitourinary malignancies to be broadly disseminated on YouTube; however, no study has assessed the quality of this content on Pinterest.

Objective

Our objective was to evaluate the quality, understandability, and actionability of genitourinary malignancy content on Pinterest.

Methods

We examined 540 Pinterest posts or pins, using the following search terms: “bladder cancer,” “kidney cancer,” “prostate cancer,” and “testicular cancer.” The pins were limited to English language and topic-specific content, resulting in the following exclusions: bladder (n=88), kidney (n=4), prostate (n=79), and testicular cancer (n=10), leaving 359 pins as the final analytic sample. Pinterest pins were classified based on publisher and perceived race or ethnicity. Content was assessed using 2 validated grading systems: DISCERN quality criteria and the Patient Education Materials Assessment Tool. The presence of misinformation was evaluated using a published Likert scale ranging from 1=none to 5=high.

Results

Overall, 359 pins with a total of 8507 repins were evaluated. The primary publisher of genitourinary malignancy pins were health and wellness groups (n=162, 45%). Across all genitourinary malignancy pins with people, only 3% (n=7) were perceived as Black. Additionally, Asian (n=2, 1%) and Latinx (n=1, 0.5%) individuals were underrepresented in all pins. Nearly 75% (n=298) of the pins had moderate- to poor-quality information. Misinformative content was apparent in 4%-26% of all genitourinary cancer pins. Understandability and actionability were poor in 55% (n=198) and 100% (n=359) of the pins, respectively.

Conclusions

On Pinterest, the majority of the urological oncology patient-centric content is of low quality and lacks diversity. This widely used, yet unregulated platform has the ability to influence consumers’ health knowledge and decision-making. Ultimately, this can lead to consumers making suboptimal medical decisions. Moreover, our findings demonstrate underrepresentation across many racial and ethnic groups. Efforts should be made to ensure the dissemination of diverse, high-quality, and accurate health care information to the millions of users on Pinterest and other social media platforms.
Peer Review of “Exploring the Reasons for Low Cataract Surgery Uptake Among Patients Detected in a Community Outreach Program in Cameroon: Focused Ethnographic Mixed Methods Study” (Preprint)
Authors: Wu Jo-Hsuan
Published: June 2022

UNSTRUCTURED

This is a peer review report related to ms# 35044.
About Microstrip Antennas
Authors: Levin Boris
Published: June 2022

The electrical characteristics of a microstrip antenna are considered. Its design and electrical characteristics are compared with design and electrical characteristics of volume self-complementary antennas and an antenna located on the faces of a lying rectangular pyramid. The method of a complex potential is used for an analysis of the substrate influence on the properties of this antenna. In accordance with the results of comparing the characteristics of linear radiators with different current distributions, the design of a microstrip antenna with an in-phase distribution was proposed, which ensures operation in a wide frequency band.
De lo invisible y de lo inasible
Authors: Cornejo Ojeda Juan Patricio
Published: June 2022

Since ancient Greece, the sense of sight has been emphasized above all other senses.  Today, in the face of certain events - invisible and intangible- such as radioactivity or viruses, the sense of sight has lost all its relevance. Other senses are beginning to gain importance and volume. The sense of touch, enters the scene directly before the invisible and the intangible, defoliating inexorably, in many cases, illness and death. Today it is forced, given our particular reality, to educate the new generations about the importance of the sense of touch. This is the subject of this article based on the philosophy of Xavier Zubiri.
Stance Prediction of Tweets on Farmers Protests in India
Authors: Kamble Aditya , Badgujar Prathamesh , Kadam Anuj , Shah Dhruv , Kadam A. J.
Published: June 2022

Abstract: Protests are an integral part of democracy and are a vital tool for the general public to convey their demands and/or discontentment to the ruling government. As voters return to term with any new rules, there are an increasing range of protests everywhere in the world for numerous socio-political reasons. With the advancement of technology, there has additionally been an exponential rise within the use of social media for the exchange of data and ideas. During this research, knowledge was gathered from the web site “twitter.com”, regarding farmers’ protest to know the feelings that the public shared on a global level. Sadly now since the Farm Laws are repealed, we have a tendency to aim to use this knowledge to know the general public stance on these laws, and whether or not it affected the government’s decision. This paper proposes a stance prediction deep learning model achieved after fine tuning the well known ULMFiT (Universal Language Model Fine-tuning) model by Howard and Ruder. Categories to be classified into are For (F), Against (A) and Neutral (N). Proposed model achieved an F1 score of 0.67 on our training and test data, which is essentially a labeled subset of the actual data. Keywords: Dataset, ULMFiT, deep learning, text classification, Language Model (LM)
Driver Drowsiness Detection System Using Machine Learning
Authors: Walke Ms. K. G. , Shete Harshvardhan , Mulani Amjad , Asknani Darshan , Gadekar Rushikesh
Published: June 2022

Abstract: We proposed to use this system to minimise the frequency of accidents caused by driver exhaustion, hence improving road safety. This device uses optical information and artificial intelligence to identify driver sleepiness automatically. We use Softmax to find, monitor, and analyse the driver's face and eyes in order to calculate PERCLOS (% of eye closure). It will also employ alcohol pulse detection to determine whether or not the person is normal. Due to extended driving durations and boredom in crowded settings, driver weariness is one of the leading causes of traffic accidents, particularly for drivers of big vehicles (such as buses and heavy trucks). Keywords: Driver Drowsiness, OpenCV, TensorFlow , Image Processing , Computer Vision
Phytochemical analysis and Antibacterial activity of Eclipta Prostrata found in Chhattisgarh region
Authors: Dani Aman Dev , Khandelwal Sonal , . Pragati
Published: June 2022

Abstract: Eclipta prostrata (bhringraj) widely known for its hair growth effects also have medicinal properties. Being one of the tribal state, herbal plants had been used by locals as well as tribals of Chhattisgarh. Present study focus on the study of phytochemicals and antibacterial property of Eclipta prostrata so as to amplify the knowledge of its medicinal properties which might be useful in further research. Results revealed the presence of active phytochemicals like alkaloids, flavonoids, terpenoids, anthraquinones, proteins, phenols, tannins, saponins and glycosides in the plant. TLC analysis showed the presence of important phytosterol: stigmasterol . Methanolic extract of plant showed antibacterial property against E coli, Bacillus s and streptococcus which indicates that the plant might show assuring results in the field of antibiotics. Above data might also help to spread awareness among the tribal people of Chhattisgarh about the medicinal values of Eclipta prostrata. Keywords: Antimicrobial activity, Hot Percolation Method, phytochemical analysis, Sterols, Local tribes
Improve the Recognition Accuracy of Sign Language Gesture
Authors: Trivedi Kaustubh , Gaikwad Priyanka , Soma Mahalaxmi , Bhore Komal , Agarwal Prof. Richa
Published: June 2022

Abstract: Image classification is one of classical issue of concern in image processing. There are various techniques for solving this issue. Sign languages are natural language that used to communicate with deaf and mute people. There is much different sign language in the world. But the main focused of system is on Sign Language (SL) which is on the way of standardization in that the system will concentrated on hand gestures only. Hand gesture is very important part of the body for exchange ideas, messages, and thoughts among deaf and dumb people. The proposed system will recognize the number 0 to 9 and alphabets from American Sign Language. It will divide into three parts i.e. preprocessing, feature extraction, classification. It will initially identify the gestures from American Sign language. Finally, the system processes that gesture to recognize number with the help of classification using CNN. Additionally we will play the speech of that identified alphabets. Keywords: Hybrid Approach, American Sign Language, Gesture Recognition. Feature Extraction
Mecanum Wheel: An Emerging Trend for Land-based Vehicle
Authors: Gaikwad Mrs. V. S.
Published: June 2022

Abstract: Rover is an unmanned vehicle which travels and collect data in difficult-to-reach places where a human being cannot work. The Proposed framework of this project is to use a rover as a platform for sensing devices and application-specific devices and to overcome the issue of humans, rescue and research team and their delays through innovation.
Real-Time Sign Language Detection using TensorFlow, OpenCV and Python
Authors: Verma Prashant , Badli Khushboo
Published: June 2022

Abstract: Deaf and hard-of-hearing persons, as well as others who are unable to communicate verbally, utilise sign language to communicate within their communities and with others. Sign languages are a set of preset languages that communicate information using a visual-manual modality. The dilemma of real-time finger-spelling recognition in Sign Language is discussed. We gathered a dataset for identifying 36 distinct gestures (alphabets and numerals) and a dataset for typical hand gestures in ISL created from scratch using webcam images. The system accepts a hand gesture as input and displays the identified character on the monitor screen in real time. This project falls under the category of human-computer interaction (HCI) and tries to recognise multiple alphabets (a-z), digits (0-9) and several typical ISL hand gestures. To apply Transfer learning to the problem, we used a Pre-Trained SSD Mobile net V2 architecture trained on our own dataset. In the vast majority of situations, we constructed a robust model that consistently classifies Sign language. Many studies have been done in the past in this area employing sensors (such as glove sensors) and other image processing techniques (such as edge detection technique, Hough Transform, and so on), but these technologies are quite costly, and many people cannot afford them. During the study, various human-computer interaction approaches for posture recognition were investigated and evaluated. The optimum solution was determined to comprise a set of image processing approaches with Human movement categorization. Without a controlled background and low light, the system can detect chosen Sign Language signs with an accuracy of 70-80%. As a result, we're creating this software to assist such folks because it's free and simple to use. However, aside from a small group of people, not everyone is familiar with sign language, and they may need an interpreter, which may be cumbersome and costly. This research intends to bridge the communication gap by building algorithms that can anticipate alphanumeric hand motions in sign language in real time. The main goal of this research is to create a computer-based intelligent system that will allow deaf persons to interact effectively with others by utilising hand gestures. Keywords: Pre-Trained SSD Mobile net V2, Sign Language , HCI
Stress Analysis of Brainwave Using EEG Click
Authors: Dave Shreya , Ambudkar Dr. Bhavna , Dave Neelum
Published: June 2022

Abstract: People in today’s world thrive on perfection and performance, which leads to an increase in stress. The damage caused by stress is often underrated. An increase in stress affects our mental health and can lead to various long-term physical implications. These include diabetes, high blood pressure, headache, weak immune system, and many others It is a social phenomenon that needs to be monitored closely. Thus, it is necessary to detect stress in early-stage and take measures to reduce it. In our study, we aim to detect stress using brainwaves. Keywords: brainwaves, stress, EEGClick, Arduino, PSD
Spreading Terrorism, Militancy, and Radicalization in Malakand Division Khyber Pakhtunkhwa Pakistan: An Analysis of the Economic Factors
Authors: Naz A. , Ullah S. , Khan M. H. , Khan N.
Published: June 2022

The current study is to analyze the causes of militancy, terrorism, and radicalization where multifarious factors are contributing towards spreading such behavior. However, the study is delimited to focus on the economic factors, including poverty, unemployment and other such factors that lead towards militancy, terrorism, and radical behavior in society. The field information was collected from 200 respondents using purposive sampling technique with stratified approach from 3 strata of the society including businessmen, teachers and clergy or religious class of age 20 and above. The data was collected through a structured interview schedule, and the analysis was made in the form of tables, discussion and the findings have been verified through chi-square test. The findings show that militancy, terrorism, and radicalization have their roots in deep rooted poverty, unemployment, and lack of other life facilities in the area. The study suggests proper planning for provision of jobs, equal distribution of resources among people and provision of life facilities to the masses.
Immigration to the USA: Current Opinions on the Ukraine and Latin America Countries
Authors: West D. J.
Published: June 2022

The U.S. stands in solidarity with our allies in NATO and European Countries regarding the Ukrainian invasion and war atrocities. The vast majority of Americans support efforts to help Ukrainian people during this Russian military invasion. It is a well-known fact that large communities of Ukrainians live in the U.S. and have American citizenship. Immigration from the Ukraine to the U.S. has existed for decades. Americans support lawful immigration from other countries into the U.S. Overall, more Americans approve than disapprove of President Biden’s response to this Russian invasion and humanitarian crisis. There is bipartisan support for limited U.S. intervention but a plurality of Republicans think the U.S. should be doing more in providing Ukraine with military support. There needs to be a balance between avoiding a larger military conflict with Russia and increasing economic pressure.
Marginalized Groups and their Health in Society
Authors: Didic R.
Published: June 2022

Introduction: Health has its own social determinants (www. schulich.uwo.ca, 2022) which considerably affect the quality of provided healthcare (Baah, 2019). Chronic diseases place a significant burden on people in vulnerable social classes, races, and lower socio-economical positions and also on other groups of minorities (Havranek et al., 2015). Methods: The essence of our research was the comparison of the results of preventive medical examinations between marginalized and non-marginalized groups of patients. The chisquared test, T-test and the Chi-squared Independence Test for the contingency table were used in the processing of the data obtained. Results: In the overall evaluation of particular groups, we confirmed the significantly worse results of preventive medical examinations among marginalized patients compared to the majority population.Conclusion: The results of our research clearly confirmed a significantly higher incidence of cardiovascular risk factors among patients living in a marginalized group. Simultaneously, the results predict a higher prevalence of colon cancer in this group. Social justice is a challenge for public health and social work.
Efficacy of biosurfactant as a coating material for post-harvest preservation of jamun fruit (Syzygium cumini)
Authors: Solanki Jyoti , More Sayali , Jodhani Kaushik , Patel Dhaval , Nataraj M.
Published: June 2022

Syzygium cumini L., Indian blackberry, popularly known as ‘jamun’, is an extremely perishable fruit with high antioxidant, nutritive and medicinal values. The present study investigated the efficacy of biosurfactant alone and/or in combination with gum ghatti and xanthan gum as edible coating to enhance shelf life and quality of jamun fruit. Coating treatments included 3% gum ghatti (T1), 0.1% xanthan gum (T2), 2% biosurfactant (T3), 3% gum ghatti and 2% biosurfactant (T4), and 0.1% xanthan gum and 2% biosurfactant (T5). Fruit quality was checked at regular intervals by evaluating physiochemical parameters and enzyme assays. The coating treatments reduced weight loss and decay percentage of jamun compared to the control. The increase of total soluble solid concentration was less in fruits treated with gum ghatti ans well as xanthan gum and biosurfactant than in the control. Moreover, sugar (glucose, fructose and sucrose) concentration was lower in treated fruit, especially, in the treatment with biosurfactant alone and in combination with gum ghatti. Concentration of phenolic substances increased in fruit treated with biosurfactant and in combination with xanthan gum. Concentration of ascorbic acid remained unchanged in fruit coated with biosurfactant. Activity of cell wall degrading enzymes was reduced in biosurfactant-treated fruit throughout the storage period. Conclusively, biosurfactant can be used as a promising edible coating, as it delays metabolic changes, maintains firmness and quality of jamun, and therefore increases the shelf life of jamun during postharvest storage.
Floral characteristics support nocturnal pollination and pollination syndrome in Barringtonia racemosa
Authors: Bagangao Meijei T. , Manila-Fajardo Analinda C.
Published: June 2022

To test for pollination syndrome and to complement records of foraging visitors of an associate mangrove, Barringtonia racemosa (L.) Spreng., aspects of its floral biology were investigated. Phenology and floral rewards (pollen viability, pollen histochemistry and nectar sugar concentration) were focused on owing to their role in plant-pollinator interaction. During the floral opening at 19:00, pollen viability, lipid presence and nectar sugar concentration were highest at 88.05 ± 0.98%, 80.69 ± 10.51%, and 68.98 ± 1.09% mg flower–1, respectively. Starch presence in pollen was rather low (mean 24.95 ± 14.58%), due to hydrolysis of starch occurring during anthesis. These floral characteristics, which reflected the highest reproductive activity, coincided with nocturnal foraging of previously recorded moth visitors. Although bats were rarely observed in previous studies, nocturnal anthesis complemented with the recorded large amount of sugar in nectar (68.98 ± 1.09% mg flower–1 = 1158 J) might be sufficient to provide the average needs of nocturnally foraging bats. Investigation of floral characteristics to complement observation of floral visitors is highly recommended to give a better understanding of the pollination system. Moreover, this study supports the pollination syndrome concept, emphasizing the need for investigation of the role of floral rewards in plant-pollinator relationships.
Indirect organogenesis in Ephedra foliata
Authors: Singh Mahabir , Yadav Kuldeep , Singh Narender
Published: June 2022

Ephedra foliata Boiss. ex C.A. Mey (Ephedraceae) is a well-known source of the alkaloid ephedrine used for the treatment of chronic asthma and associated respiratory ailments. This investigation was conducted to standardize an efficient regeneration protocol for E. foliata via indirect organogenesis through intermodal explants. Maximum callus induction (80.3%) was achieved on Murashige and Skoog (MS) medium supplemented with 0.5 mg L‑1 2,4‑dichlorophenoxyacetic acid + 0.5 mg L‑1 kinetin and additives (50 mg L‑1 ascorbic acid and 25 mg L‑1 citric acid). The maximum shoot regeneration (n = 5.27) was achieved on MS medium containing 6.0 mg L‑1 kinetin, followed by 5.0 mg L‑1 6‑benzylamino purine (n = 4.27). MS half strength medium with 3.0 mg L‑1 α‑naphthalene acetic acid resulted in the highest rooting percentage (32%). Sixty percent of the plantlets survived during acclimatization and were successfully transferred under field conditions. These plants and callus will be a suitable source of plant material for mass multiplication, genetic modification for enhanced bioactive constituents, and germplasm conservation.