bluuebunny/crossref_metadata_2025 huggingface dataset:
Improved Digital Therapy for Developmental Pediatrics Using Domain-Specific Artificial Intelligence: Machine Learning Study
Authors: Washington Peter , Kalantarian Haik , Kent John , Husic Arman , Kline Aaron , Leblanc Emilie , Hou Cathy , Mutlu Onur Cezmi , Dunlap Kaitlyn , Penev Yordan , Varma Maya , Stockham Nate Tyler , Chrisman Brianna , Paskov Kelley , Sun Min Woo , Jung Jae-Yoon , Voss Catalin , Haber Nick , Wall Dennis Paul
Published: January 2022

Background

Automated emotion classification could aid those who struggle to recognize emotions, including children with developmental behavioral conditions such as autism. However, most computer vision emotion recognition models are trained on adult emotion and therefore underperform when applied to child faces.

Objective

We designed a strategy to gamify the collection and labeling of child emotion–enriched images to boost the performance of automatic child emotion recognition models to a level closer to what will be needed for digital health care approaches.

Methods

We leveraged our prototype therapeutic smartphone game, GuessWhat, which was designed in large part for children with developmental and behavioral conditions, to gamify the secure collection of video data of children expressing a variety of emotions prompted by the game. Independently, we created a secure web interface to gamify the human labeling effort, called HollywoodSquares, tailored for use by any qualified labeler. We gathered and labeled 2155 videos, 39,968 emotion frames, and 106,001 labels on all images. With this drastically expanded pediatric emotion–centric database (>30 times larger than existing public pediatric emotion data sets), we trained a convolutional neural network (CNN) computer vision classifier of happy, sad, surprised, fearful, angry, disgust, and neutral expressions evoked by children.

Results

The classifier achieved a 66.9% balanced accuracy and 67.4% F1-score on the entirety of the Child Affective Facial Expression (CAFE) as well as a 79.1% balanced accuracy and 78% F1-score on CAFE Subset A, a subset containing at least 60% human agreement on emotions labels. This performance is at least 10% higher than all previously developed classifiers evaluated against CAFE, the best of which reached a 56% balanced accuracy even when combining “anger” and “disgust” into a single class.

Conclusions

This work validates that mobile games designed for pediatric therapies can generate high volumes of domain-relevant data sets to train state-of-the-art classifiers to perform tasks helpful to precision health efforts.
Requirements for a Bespoke Intensive Care Unit Dashboard in Response to the COVID-19 Pandemic: Semistructured Interview Study
Authors: Davidson Brittany , Ferrer Portillo Katiuska Mara , Wac Marceli , McWilliams Chris , Bourdeaux Christopher , Craddock Ian
Published: January 2022

Background

Intensive care units (ICUs) around the world are in high demand due to patients with COVID-19 requiring hospitalization. As researchers at the University of Bristol, we were approached to develop a bespoke data visualization dashboard to assist two local ICUs during the pandemic that will centralize disparate data sources in the ICU to help reduce the cognitive load on busy ICU staff in the ever-evolving pandemic.

Objective

The aim of this study was to conduct interviews with ICU staff in University Hospitals Bristol and Weston National Health Service Foundation Trust to elicit requirements for a bespoke dashboard to monitor the high volume of patients, particularly during the COVID-19 pandemic.

Methods

We conducted six semistructured interviews with clinical staff to obtain an overview of their requirements for the dashboard and to ensure its ultimate suitability for end users. Interview questions aimed to understand the job roles undertaken in the ICU, potential uses of the dashboard, specific issues associated with managing COVID-19 patients, key data of interest, and any concerns about the introduction of a dashboard into the ICU.

Results

From our interviews, we found the following design requirements: (1) a flexible dashboard, where the functionality can be updated quickly and effectively to respond to emerging information about the management of this new disease; (2) a mobile dashboard, which allows staff to move around on wards with a dashboard, thus potentially replacing paper forms to enable detailed and consistent data entry; (3) a customizable and intuitive dashboard, where individual users would be able to customize the appearance of the dashboard to suit their role; (4) real-time data and trend analysis via informative data visualizations that help busy ICU staff to understand a patient’s clinical trajectory; and (5) the ability to manage tasks and staff, tracking both staff and patient movements, handovers, and task monitoring to ensure the highest quality of care.

Conclusions

The findings of this study confirm that digital solutions for ICU use would potentially reduce the cognitive load of ICU staff and reduce clinical errors at a time of notably high demand of intensive health care.
Spin in Abstracts of Systematic Reviews and Meta-analyses of Melanoma Therapies: Cross-sectional Analysis
Authors: Nowlin Ross , Wirtz Alexis , Wenger David , Ottwell Ryan , Cook Courtney , Arthur Wade , Sallee Brigitte , Levin Jarad , Hartwell Micah , Wright Drew , Sealey Meghan , Zhu Lan , Vassar Matt
Published: January 2022

Background

Spin is defined as the misrepresentation of a study’s results, which may lead to misperceptions or misinterpretation of the findings. Spin has previously been found in randomized controlled trials and systematic reviews of acne vulgaris treatments and treatments of various nondermatological conditions.

Objective

The purpose of this study was to quantify the presence of spin in abstracts of systematic reviews and meta-analyses of melanoma therapies and identify any related secondary characteristics of these articles.

Methods

We used a cross-sectional approach on June 2, 2020, to search the MEDLINE and Embase databases from their inception. To meet inclusion criteria, a study was required to be a systematic review or meta-analysis pertaining to the treatment of melanoma in human subjects, and reported in English. We used the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) definition of systematic reviews and meta-analyses. Data were extracted in a masked, duplicate fashion. We conducted a powered bivariate linear regression and calculated odds ratios for each study characteristic.

Results

A total of 200 systematic reviews met the inclusion criteria. We identified spin in 38% (n=76) of the abstracts. The most common type of spin found was type 3 (selective reporting of or overemphasis on efficacy outcomes or analysis favoring the beneficial effect of the experimental intervention), occurring 40 times; the least common was type 2 (title claims or suggests a beneficial effect of the experimental intervention not supported by the findings), which was not present in any included abstracts. We found that abstracts pertaining to pharmacologic interventions were 3.84 times more likely to contain spin. The likelihood of an article containing spin has decreased annually (adjusted odds ratio 0.91, 95% CI 0.84-0.99). No significant correlation between funding source or other study characteristics and the presence of spin was identified.

Conclusions

We have found that spin is fairly common in the abstracts of systematic reviews of melanoma treatments, but the prevalence of spin in these abstracts has been declining from 1992-2020.
INVESTIGATION OF CANCER CELLS USING THIN LAYERS OF CADMIUM OXIDE (CdO)–DNA/RNA SANDWICHED COMPLEX COMPOSITE PLASMONIC NANOSTRUCTURE UNDER SYNCHROTRON RADIATION
Authors: HEIDARI ALIREZA
Published: January 2022

Triptycene Barrelene Anthracene (TBA) is a polycyclic aromatic hydrocarbon consisting of three benzene rings. The name TBA is a composite of phenyl and TBA. In its pure form, it is found in cigarette smoke and is a known irritant, photosensitizing skin and industrial carcinogenic wastewater. Cadmium Oxide (CdO) is an inorganic compound with the formula CdO. It is one of the main precursors to other cadmium compounds. It crystallizes in a cubic rocksalt lattice-like sodium chloride, with octahedral cation and anion centers. It occurs naturally as the rare mineral monteponite. CdO can be found as a colorless amorphous powder or as brown or red crystals. CdO is an n-type semiconductor with a bandgap of 2.18 eV (2.31 eV) at room temperature (298 K). DNA/RNA, CdO and DNA/RNA–CdO sandwiched complex was characterized by Attenuated Total Reflection–Fourier Transform–Infrared (ATR–FTIR) spectroscopy, Raman spectroscopy, X–Ray Diffraction (XRD) technique and Energy–Dispersive X–Ray (EDAX) spectroscopy. The modified anti–cancer-protective membrane was characterized by Scanning Electron Microscope (SEM), EDAX analysis, 3D–Atomic–Force Microscopy (3D–AFM), Transmission Electron Microscopy (TEM) and contact angle analyses and methods. The current study is aimed to use Polysorbate 80 as a surfactant for investigating the effectiveness of permeate TBA on the Polyether Ether Ketone (PEEK) anti–cancer-protective membrane and the effect of loading DNA/RNA–CdO sandwiched complex on hydrophilicity and anti-cancer properties. The results showed decreasing surface pore size from 227 to 176 and increasing porosity from 101 to 111 with loading DNA/RNA–CdO sandwiched complex, and the permeate of anti–cancer-protective membrane increased from 80 to 220 (L/m2. hr. bar) with loading DNA/RNA–CdO sandwiched complex.
GINGER LOADED CHITOSAN NANOPARTICLES FOR THE MANAGEMENT OF 3–NITROPROPIONIC ACID-INDUCED HUNTINGTON’S DISEASE-LIKE SYMPTOMS IN MALE WISTAR RATS
Authors: AKILA R. M. , MARIA SHAJI DONA
Published: January 2022

Objective: The purpose of this research work is to enhance bioavailability and brain delivery of ginger through the development of ginger-loaded chitosan nanoparticles and evaluation of its neuroprotective potential against 3-Nitropropionic acid (3-NP) induced Huntington’s Disease model rats.
Methods: Ginger-loaded chitosan nanoparticles were developed as five different formulations (F1-F5) by the ionic gelation method. Based on their release, formulations F1 and F3 were chosen for physicochemical characterization. The neuroprotective activity of formulations F1 and F3 were evaluated by behavioural (Neurological scoring, Hanging wire test, Elevated plus maze test), biochemical (estimation of lipid peroxidation, glutathione, protein, superoxide dismutase, catalase) and neurochemical (estimation of acetylcholine esterase inhibition) tests in comparison with ginger extract in Huntington’s Disease (HD) model rats.
Results: Formulations F1 and F3 showed almost similar and significant controlled release. Formulation F1 showed spherical nanoparticles with optimum size range and negative zeta potential. The behavioural assessment revealed that there was an improvement in gait, movement, grip strength and memory in ginger-loaded chitosan nanoformulations administered to rats than ginger extract administered rats. Biochemical and neurochemical analyses also proved that ginger-loaded chitosan nanoformulations had greatly lowered the oxidative stress parameters such as malondialdehyde and protein carbonyls in comparison with ginger extract (p<0.05). The ginger nanoformulations had highly increased the activity of antioxidant enzymes such as superoxide dismutase, glutathione and catalase by reducing the formation of free radicals than ginger extract (p<0.05). The memory and cognition of ginger nanoformulations administered Wistar rats had highly improved than ginger extract administered Wistar rats (p<0.05 due to inhibition of acetylcholine esterase enzyme).
Conclusion: The current study indicated that ginger-loaded chitosan nanoparticles have a superior neuroprotective effect than their extract due to their nano size, which facilitates their entry across the blood-brain barrier and eventually improves the bioavailability of ginger.
IMPACT OF ACNE VULGARIS ON A PERSON’S QUALITY OF LIFE AND IT’S CORRELATION WITH THE CLINICAL SEVERITY PRE AND POST-DRUG THERAPY
Authors: PHUKAN SWOPNA , DAS SAHELI
Published: January 2022

Objective: The aim of the study is to assess the therapeutic efficacy of drugs used in acne vulgaris by measuring the severity of acne using the Global Acne Grading System score (GAGS) and Cardiff Acne Disability Index (CADI) questionnaire score pre and post-drug therapy. Methods: The present study was conducted in the Department of Dermatology after getting approval from the Institutional Ethics Committee (No MC/190/2007/Pt1/MAR-2019/PG/123) dated 10/04/2019. It was an observational study for a period of 1 y. 172 patients were enrolled in the study. Patients were divided into 4 grades depending on their clinical manifestation. The severity of acne vulgaris and the quality of life were measured using the GAGS scale and the CADI questionnaire, respectively at the first visit and at the follow-up visit in all the grades of acne vulgaris. A correlation was done between the GAGS and the CADI score at the follow-up visit in all grades of acne. Results: It was observed that the GAGS score and the CADI score was significantly improved at the F/U visit (p<0.05) as compared to baseline in all the 4 grades of acne. A correlation between GAGS score and QoL using CADI scale was done using Pearson Parametric Correlation Test. In none of the groups, the correlation was significant (p>0.05). Conclusion: We can conclude from our study that following treatment with drugs, the clinical severity of acne decreased and there was also a significant improvement in the quality of life of patients.
ROLE OF BIOMARKERS IN EPILEPTOGENESIS: A CONCISE REVIEW
Authors: BARAVKAR ATUL A. , D. SHINDE SAGAR , AHER NITIN B.
Published: January 2022

Epilepsy is a gathering of ongoing neurological problems described by intermittent, unconstrained, and unusual seizures. It is one of the most widely recognized neurological messes, influencing a huge number of individuals around the world. A biomarker is characterized as a dispassionately estimated normal for an ordinary or obsessive natural interaction. Recognizable proof and legitimate approval of biomarkers of epileptogenesis, the improvement of epilepsy, and ictogenesis, the affinity to create unconstrained seizures, may foresee the improvement of an epilepsy condition; recognize the presence and seriousness of tissue equipped for producing unconstrained seizures; measure movement after the condition is set up; furthermore, decide pharmacoresistant. Such biomarkers could be utilized to make creature models for more savvy screening of potential antiepileptogenic and antiseizure medications and gadgets and to lessen the expense of clinical preliminaries by enhancing the preliminary populace and going about as proxy markers to abbreviate the preliminary span. The destinations of the biomarker subgroup for the London Studio were to characterize approaches for distinguishing conceivable biomarkers for these reasons. Examination to recognize dependable biomarkers may likewise uncover basic instruments that could serve as helpful focuses for the improvement of new antiepileptogenic and antiseizure compounds.
Travelling Salesman Problem Generalized Interval Arithmetic
Authors: A Priya Dharshini.
Published: January 2022

Abstract: The travelling salesman problem is one of the famous combinatorial optimization problem and has been intensively studied in the last decades. We present a new extension of the basics problem, where travel times are specified as a range of possible values. Keywords: Fuzzy sets, Arithmetic operation on interval, least common method, travelling salesman problem.
Multiple-Performance Optimization of Wire EDM Parameters for HDS H13 BY Using Taguchi Method
Authors: Vats Naveen
Published: January 2022

Abstract: Wire electrical discharge machining is extensively used in machining of conductive materials. The WEDM process has the ability to machine complex shapes and hard electrically conductive metal components precisely. The main goal of wire electrical discharge machine manufacturers and users are to achieve a better stability and high productivity of the process with desired accuracy and minimum surface damage.The main objectives of the present research are to experimentally study the effect of various process parameters like pulse on time, pulse off time, wire feed, and wire tension on the performance measures like material removal rate, surface roughness and wire wear ratio. WEDM is a widely recognized unconventional material cutting process used to manufacture components with complex shapes and profiles of hard materials. In this paper we are presenting the development of WEDEM process using various pre define parameters using Taguchi method. Index Terms: WEDM, doe, orthogonal array, parameters, Taguchi method, H13, HDS, mean of means, SF, MRR, Ra, etc.
HAMBATAN PENERAPAN SANKSI PAJAK DI KPP PRATAMA PAMEKASAN
Authors: Yaqin Muhammad Ainul , Alwiyah Alwiyah
Published: January 2022

This research aims to illustrate how the processes/procedures and obstacles in the implementation of tax sanctions in KPP Pratama Pamekasan. The research method used is a case study approach. One key informant with two supporting informants, then the information was analyzed using the Miles and Huberman model consisting of data reduction, data presentation, conclusion drawing, and verification. The result of this research was first, the application of tax sanctions in KPP Pratama Pamekasan only applied to the taxpayer who is active status. Secondly, the socialization of tax sanctions conducted by KPP Pratama Pamekasan through the delivery of chain messages and also through social media has not been conveyed properly to the taxpayers. Thirdly, the barriers experienced by KPP Pratama Pamekasan in applying tax sanctions are the ignorance of taxpayers on the application of the tax sanctions themselves.
ASIMETRI INFORMASI SEBAGAI PEMODERASI PENGARUH PENERAPAN INTEGRATED REPORTING TERHADAP STOCK RETURN
Authors: Wahyuni Endang Dwi
Published: January 2022

This research aims to find empirical evidence about the Effect of the Application of Integrated Reporting on Stock Returns and whether Information Asymmetry can strengthen or weaken the Effect of the Application of Integrated Reporting on Stock Returns. This research was conducted on financial sector companies that are listed on the Indonesia Stock Exchange in 2019. The research samples were 74 companies; and the data collected were data on the application of Integrated Reporting, data of the Stock Returns, and data of Information Asymmetry. The data collection technique was conducted by using the documentation method, whole the data analysis technique was conducted by a simple regression test, followed by MRA (Moderating Regression Analysis) and hypothesis testing using the t test (partial test). Based on the results of hypothesis testing, it can be concluded that the Application of Integrated Reporting has no effect on Stock Returns, and Information Asymmetry can strengthen the relationship between the Application of Integrated Reporting and Stock Returns.
ANALISIS KINERJA INDUSTRI ROKOK YANG TERDAFTAR DI BURSA EFEK INDONESIA DENGAN PENDEKATAN RASIO PROFITABILITAS
Authors: Aini Yulis Nurul , Haryanti Agustin Dwi , Trianti Khoriyah
Published: January 2022

ABSTRACTS
This study aims to: 1. Understand how the performance of the cigarette industry in the Indonesia Capital Market. 2. Understand about the best performance among the cigarette industry. The research data was obtained from published on the Indonesia Stock Exchange and information company website in the form of financial reports for the period 2018-2020. The financial statement are analyzed using profitability ratios to explain the performance of each cigarette industry. The Profitability ratio used are ROE, ROA, NPM, and GPM. The data analysis method is descriptive and comparative by comparing the results of the calculation of the profitability ratios with the industry average standart. The result of this study indicate performance of cigarette industry was very good, except for PT. Bentoel Internasional Investama, Tbk and the best performance is PT PT. Hanjaya Mandala Sampoerna Tbk.
DETERMINANTS OF THE QUALITY OF OPERATING SEGMENT DISCLOSURE
Authors: Hidayat Arina Adilla , Vestari Mekani
Published: January 2022

The Indonesian government encourages the manufacturing sector to diversify its business. The operating segments disclosures will be more important. Meanwhile, the provisions regarding this disclosure are still voluntary. There are several studies in Indonesia. However, the proxies used do not reflect the quality of the operating segment disclosures comprehensively. Therefore, this study aims to get empirical evidence on the determinants of the quality of operating segment disclosure by using Reporting Quality Index. The population was manufacturing companies listed on the IDX for 2015 - 2018. The data analysis technique uses multiple linear regression. The results show that firm size, leverage, degree of internationalization, and audit quality have a positive effect, while industry competition, profitability, and company growth have no effect on the quality of disclosure in the operating segment. This implies that external pressures have higher impact.
PERSEPSI MAHASISWA TERHADAP KESYARIAHAN PRODUK PEGADAIAN SYARIAH
Authors: Astuti Sri Wibawani Wahyuning
Published: January 2022

The purpose of this study is to explain students' perceptions of LKS products (in this study, PT Pegadaian Syariah) and students' interest in using LKS services after having an adequate understanding of Fiqh Muamalah in Islam. This study was followed by accounting students who took muamalah fiqh courses. In this study, qualitative descriptive analysis techniques were used with primary data through a list of open questions, so that respondents were free to answer research questions. . The results of this study are students' perceptions of Sharia Pawnshop products are definitely in accordance with sharia provisions, namely the provisions of the OJK and DSN MUI fatwas, although they did not conduct a thorough study of the application of each Sharia Pawnshop product and its contracts and pillars. customers from LKS and have never received socialization related to LKS and the products offered and After understanding the importance of sharia muamalah, it turns out that the majority are not interested in using LKS services at this time, because they feel they do not need.
AKUNTABILITAS KONTEMPORER ORGANISASI PENGELOLA ZAKAT
Authors: Arifah Arifah , Muhammad Rifqi
Published: January 2022

Penelitian ini bertujuan mengevaluasi implementasi akuntabilitas pada Organisasi Pengelola Zakat (OPZ). Metode penelitian menggunakan teknik Systematic Literatur Review (SLR). SLR merupakan metode untuk mengumpulkan dan mengevaluasi penelitian-penelitian dalam suatu fokus bahasan tertentu. Hasil analisis menunjukkan Akuntabilitas OPZ dapat ditunjukkan dengan adanya Internal kontrol, pengukuran kinerja, serta kepatuhan karyawan terhadap diskripsi kerja. Kepatuhan diskripsi kerja dikaitkan dengan profesionalitas amil dalam melaporkan informasi keuangan dan non keuangan. Lebih lanjut informasi yang telah diolah amil harus dipublikasikan melalui jaringan internet yang disediakn pada website OPZ. Pengungkapan informasi pada website OPZ diperuntukkan bagi permangku kepentingan yang memerlukan informasi terkait pengelolaan zakat.
PERAN AKUNTABILITAS DAN TRANSPARANSI PEMERINTAH DESA INDONESIA TERHADAP KEPERCAYAAN MASYARAKAT DESA: KASUS DI KABUPATEN BANTUL
Authors: Sofyani Hafiez , Tahar Afrizal
Published: January 2022

This study aims to examine effect of accountability and transparency of village government on village community trust. A Mixed-methods research design with explanatory sequential model was adopted in this study. Data were collected by distributing a survey questionnaire in the first step and followed by interviews. Partial Least Square (PLS) technique was used to test the hypotheses whilst inductive thematic analysis was adopted to analyze interview data. This study discovered that the transparency enhances village community trust while accountability was in contrast. The interview results complement the result obtained from hypotheses testing using survey data. Based on the research findings, the transparency becomes a critical factor for increasing community trust in village.
Menguak Penilaian Tingkat Kesehatan Koperasi Wanita
Authors: Pramono Riko Agus , Leniwati Driana
Published: January 2022

The purpose of this study is to found see how healthy the Teratai Women Cooperative in Merjoyo Village, Purwoasri District, Kediri Regency. The aspects of capital, productive asset quality, management, efficiency, liquidity, independence and growth, as well as the cooperative's identity, are used to assess cooperatives, as per the Regulation of the Deputy for Supervision of the Ministry of Cooperatives and Small and medium enterprises of the Republic of Indonesia Number 6 of 2016. This sort of research combines qualitative descriptive research with secondary data gathered from management accountability reports presented at Annual Member Meetings, specifically the cooperative financial accounts for 2018-2020. The results of the analysis show that the Teratai Women's Cooperative's health level rating in 2018-2020 had an average final score of 56.18, indicating that the predicate is under supervision.
The Effect Of Ownership Structure On The Performance Of Intellectual Capital
Authors: Meilani Astian Yosi , Azizah Siti Nur , Pramono Hadi , Pratama Bima Cinintya
Published: January 2022

This study aims to show empirical evidence of the effect of managerial ownership, institutional ownership, foreign ownership and government ownership on intellectual capital performance as the dependent variable. This study relates the influence between these variables by expanding the concept and understanding of Resource-Based Theory, Agency Theory and Stakeholder Theory. The sample in this study is the mining sector companies listed on the Indonesia Stock Exchange in 2016-2019 using purposive sampling technique, namely selecting samples with certain criteria to get more valid results. The data analysis technique used is the classical assumption test, then the results are analyzed using multiple regression analysis to prove the influence between variables by utilizing an accurate SPSS application. The results of this study indicate that institutional ownership and foreign ownership have a positive effect on intellectual capital performance in mining companies, while managerial ownership and government ownership do not show any effect on intellectual capital performance in mining companies in Indonesia. This research contributes to the theory and practice of companies in the conduct of business. However, this study has not been able to prove the influence of managerial and government ownership on intellectual capital performance, so that further research can consider other corporate sectors whose managerial and government ownership is quite dominant.
Analisis Penggunaan Metode Pembelajaran Resitasi Pada Mahasiswa Akuntansi
Authors: Magdalena Marlina
Published: January 2022

This study aims to determine the effect of applying the recitation method on the learning outcomes of Introduction to Accounting 2. The subjects in this study were Semester 2 students of the Accounting Department. This type of research is an experimental study with a nonequivalent control group design. Data analysis in this study used the one way ANOVA test. The results of this study indicate that the average value of student learning outcomes given the application of the recitation learning method is not significantly different from the application of the lecture learning method but still can improve student learning outcomes so that it can be used as a learning method in accounting.
A New Goodness of Fit Measure Based on Income Inequality Curves
Authors: Mirzaei Shahryar , Jahanshahi S. M. A.
Published: January 2022

This paper uses inequality-measurement techniques to assess goodness of fit in income distribution models. It exposes the shortcomings of the use of conventional goodness of fit criteria in face of the big income data and proposes a new set of metrics, based on income inequality curves. In this note, we mentioned that the distance between theoretical and empirical inequality curves can be considered as a goodness of fit criterion. We demonstrate certain advantages of this measure over the other general goodness of fit criteria. Unlike other goodness of fit measures, this criterion is bounded. It is 0 in minimum difference and 1 in maximum distance. Furthermore, there is a consistency between this new goodness of fit measure and the other conventional criteria. A simulation study based on fitted distribution to real income data is performed in order to investigate some statistical properties of the new goodness of fit measure. An empirical study and comparisons are also provided.
Simulación mediante CDF de una chimenea solar inclinada sobre la cubierta
Authors: Rodríguez-Trejo Sandra , Fuentes-Freixanet Víctor
Published: January 2022

In recent years, energy consumption from electrical devices to foster air movement in regions with warm climates has risen, with the resulting negative impact on the environment. The purpose of this paper is to evaluate the performance of a solar chimney used to induce natural ventilation in a closed space, under the weather conditions of the hot humid Mexican climate. For this purpose, CFD simulations were run using the RNG k- ɛ turbulence model and the DO radiation model, considering only natural convection phenomena. The solar chimney performance was evaluated, comparing the results of the simulations with experimental measurements, analysis which showed a good match. Temperatures of up to 46.5%°C in the air within the chimney, and of 77.1°C on the absorption plate, were obtained, results that allow verifying the influence of the heat discharge phenomenon by the natural flotation of air in the chimney.
El rol activo del usuario en la búsqueda de confort térmico de viviendas en clima templado árido
Authors: Andreoni-Trentacoste Soledad Elisa , Ganem-Karlen Carolina
Published: January 2022

User behavior is one of the main factors of uncertainty in the thermal performance of a dwelling. This study contributes to identifying variables that would influence the user behavior and, in turn, how these affect the thermal performance of houses located in the city of Mendoza. For this, a thermal audit of a representative dwelling was made in summer and winter, while also recording occupancy and occupant actions. It was concluded that, in summer, correct management of the envelope through night cooling favors reaching indoor comfort in 89% of the recorded data. In winter, the correct use of direct solar gain favors reaching comfort in 60% of the recorded data. Finally, alternatives for building improvements are evaluated for the most unfavorable season.
Evaluación térmica y lumínica en prototipos de cubiertas ligeras, para clima cálido húmedo
Authors: Ortiz-Zambrano Edison Bolivar , Torres-Quezada Jefferson , Véliz-Párraga José Fabián
Published: January 2022

The zinc sheet roof is one of the most popular elements in Latin American architecture, and in many other regions with warm humid climates. Creating lighting and thermal alternatives focused on this typology would imply major benefits in the environmental and social fields. This study carried out in Manabí, Ecuador, evaluates three prototypes of light roofs, combining zinc with PVC, in order to determine the correct configuration of translucent material to create environments that are within thermal and lighting parameters. The results indicate that the empirical solutions model has the lowest variation in indoor temperature, with 32.63%, unlike the 32.97% of the cross-type model, and the 34.40% of the side strip model. Additionally, it was seen that the greatest influence of solar radiation on the roof is recorded from 1:00 p.m. to 2 p.m. approximately
Isolation and characterization of Rhodococcus qingshengii, a cellulolytic bacteria from Cnaphalocrocis medinalis (Lepidoptera: Crambidae) gut
Authors: Biswas Sumita , Paul Dibyendu
Published: January 2022

Herbivorous Lepidopteran insects depend on microbial cellulases for cellulose digestion. The present study aimed to investigate the herbivorous Lepidoptera Cnaphalocrocis medinalis gut for isolation of cellulose degrading bacteria. A Gram positive rod, non-motile, mesophilic, neutrophile bacterial strain TCI11 was isolated from C. medinalis (Lepidoptera: Crambidae) 5th instar larvae gut. The isolate was found to be a potent cellulose degrader, which was isolated on carboxymethylcellulose agar medium using carboxymethylcellulose as a sole carbon source and screened by Congo red and Gram’s iodine dye staining method. The cellulose degrading strain was characterized on the basis of Gram staining, morphological and biochemical properties. Based on 16S rRNA gene analysis, the strain was found to be most closely related to Rhodococcus baikonurensis, Rhodococcus erythropolis, Rhodococcus globerulus (99.77, 99.35 and 99.06% similarity, respectively) and was identified as Rhodococcus qingshengii. R. qingshengii is being reported for the first time as a potent cellulose degrader. The source of isolation of this particular bacterial strain is also novel.
Exploring antagonistic actinobacteria from a mangrove ecosystem of the southern coast of India against multidrug-resistant pathogens
Authors: Joshua Sam Albert , Sangeetha Nallathambi , Iniyan Appadurai Muthamil , Vincent Samuel Gnana Prakash
Published: January 2022

There is an urgent need to find new ways to fight multidrug-resistant pathogens, and search for novel microbial metabolites is one of the common strategies. The aim of the current study was to screen actinomycete isolates from a marine-associated ecosystem, for active compounds against multidrug-resistant human pathogens. A total of 14 morphologically distinct isolates from coastal mangrove soil were screened against seven pathogens and were found to be active against at least two pathogens. The antagonistic metabolite production studies revealed that the initial antibacterial activity of isolates against methicillin-sensitive and resistant strains of Staphylococcus aureus was observed on the first day of visible growth. Two strains, ICN937 and ICN938, were active against Acinetobacter baumannii, and were selected for further molecular identification and quantitative antibacterial analysis. Phylogenetic analysis based on 16S rRNA showed association of ICN937 to Streptomyces antibioticus NBRC 12838T and of ICN938 to Streptomyces rubiginosohelvolus CSSP731T. This study provides an evidence that mangrove ecosystems in coastal areas could be used as a source for active microbial metabolite producers.
Digestive Disease Mortality Dynamics During New Coronavirus Infection Pandemic in Different Subjects of Russian Federation
Authors: Ivashkin V. T. , Sheptulin A. A. , Alekseeva O. P. , Alekseenko S. A. , Baranovsky A. Yu. , Zolnikova O. Yu. , Korochanskaya N. V. , Mammayev S. N. , Khlynov I. B. , Tsukanov V. V.
Published: January 2022

Aim. An analysis of digestive disease mortality dynamics in different subjects of the Russian Federation in course of the new coronavirus infection pandemic.

Key points. In most subjects of the Russian Federation, the first half of 2021 enduring the COVID-19 pandemic has witnessed a higher overall mortality from digestive diseases and from peptic ulcer, liver and pancreatic illnesses compared to the same period in 2020. This situation may have roots in both the adverse impact of coronavirus infection on pre-existing digestive diseases and shortages in providing specialty medical aid to gastroenterological patients during the pandemic. Improved outpatient care and remote counselling, as well as successful educational measures, may reduce gastroenterological disease-associated mortality.

Conclusion. Most regions of Russia have registered a growing mortality from digestive diseases at the new coronavirus infection pandemic due to the SARS-CoV-2 adverse impact on illness progression, as well as imposed difficulties in providing specialty medical aid.
K.S. Maniam’s Bestiary: Reading Animality and Identity in Selected Stories
Authors: S. K. Yeow Agnes
Published: January 2022

This essay scrutinises K.S.Maniam’s fictional animals by going beyond the confines of metaphor to interrogate the concept of animality and how animality impinges on diasporic identity. I examine the writer’s impulse to animalise the notion of national belonging especially though thestrategic deployment of the animal mask which reveals the shared domination of migrant and animal. I argue that Maniam’s critique of animality not only suggests that migrant and animal lives are interlinked but also informs his re-envisioning of the diasporic self. I positthat Maniam’s “new diaspora”advances the notion of diasporic self as ‘becoming-animal.’
Rereading Empire, Rethinking History: Rehabilitation of the Vietcong in Lan Cao’s Monkey Bridge
Authors: Shu Yuan
Published: January 2022

Throughits reading of Lan Cao’s Monkey Bridge, credited as the first Vietnamese American novel, this article seeksto investigate the discourse of reconciliation or refugee settlement in the context of the changing US master narratives from Empire to Cold War 2.0. Itarguesthat Cao’s novel in its effort to register a South Vietnamese perspective reorients modern Vietnamese experiences in relation to the US sense of democracy and freedom and in the process challenges what Donald Pease calls the state fantasy of American exceptionalism in the US military intervention in Vietnam. What Cao’s novel achieves is to blur the boundary between nationalism and communism in its representation of the Vietnamese struggle for independence in its early stage and to humanize and rehabilitate the Vietcong soldier as a possibly assimilable “us” rather than as simply “them” in the realm of the other.
When Asian Americans Return to Asia: Return Narratives, Transpacific Imagination, and the Post/Cold War
Authors: Wang Chih-ming
Published: January 2022

By focusing on Asian American return narratives as a symbolic indicator of a shift in transpacific relations, this article attempts to address two questions: first, how will a focus on return experiences engage and reframe transpacific imperial geopolitics thatcreated and sustainedAsian American literature, and second, how will a focus on the “post/Cold War”rather than on globalization as a temporal frame challenge the transpacificimagination in American studiesas a cultural and economic narrative of immigration, integration,and salvationthat purports to transcend Cold War divisions.Thearticleanalyses Maxine Hong Kingston’s I Love a Broad Margin to My Life(2011) and Chang-rae Lee’s My Year Abroad(2021)to consider how post-1990s Asian American return narratives rearticulatecontemporary geopolitics. It will conclude with a reflection on the Orientalismof Asian Americanliteraturein the treacherous imaginaryof transpacific futures.
Inflammation and Intracellular Exposure of Dolutegravir, Darunavir, Tenofovir and Emtricitabine in People living with HIV
Authors: Ferrara Micol , Salvador Elena , Trentalange Alice , Alcantarini Chiara , Trunfio Mattia , Cannizzo Elvira Stefania , Bono Valeria , Nozza Silvia , Nicolò Amedeo De , Ianniello Alice , Vivo Elisa De , D'Avolio Antonio , Perri Giovanni Di , Bonora Stefano , Marchetti Giulia , Calcagno Andrea
Published: January 2022

Background: Antiretroviral therapy reduces systemic inflammation and
immune activation, but not to levels like HIV-negative. Limited drug
penetration within tissues has been argued as potential mechanism of
persistent inflammation. Data on the role of inflammation on
plasma/intracellular (IC) pharmacokinetics (PK) of ARV drugs through to
downregulation/expression of cytochrome P450 3A/membrane transport
proteins are limited. Aim of this study was to investigate the
correlation between inflammation markers and plasma/IC PK of different
ARVs regimen in HIV-positive patients. Methods: We included in the study
ART-treated HIV+ pts switching to 3 different ARV regimens: 1) DTG-based
dual-therapy plus boosted-PIs, 2) DTG-based triple-therapy without PIs,
3) DRV/c-based triple-therapy. Plasma and IC ARV drugs concentration
means at the end of dosing interval (T0), IM on samples concomitantly
with ARV PK determination: sCD14, CRP, IL-6 and LPS were analysed.
Results: 60 samples from pts included in the switching study were used
for measuring plasma and IC concentrations of HIV drugs. No
significative differences between CRP, sCD14, IL-6 and LPS values in 3
arms of therapy were observed. Significant correlation was observed
between tenofovir plasma concentrations and sCD14 (p<0.001),
DRV plasma concentration and sCD14 (p=0,07) and DRV IC/plasma ratio and
Log10 IL-6 concentrations (p=0.04). Furthermore, in 24 pts on DTG-TT, we
observed a negative trend between DTG IC concentrations and sCD14
(p=0.09). Conclusions: Our preliminary data support the hypothesis of
lower IC concentrations of DRV and DTG in pts with higher plasma IM,
suggesting an interplay between HIV drug penetration and persistent
inflammation in cART-treated HIV-positive patients.
Process Mapping Strategies to Prevent Subcutaneous Implantable Cardioverter-Defibrillator Infection
Authors: Weiss Raul , Mark George , El-Chami Mikhael , Biffi Mauro , PROBST VINCENT , Lambiase Pier , Miller Marc , McClernon Timothy , Hansen Linda , Knight Bradley , Baddour Larry
Published: January 2022

Background: Infection remains a major complication of cardiac
implantable electronic devices (CIEDs) and can lead to significant
morbidity and mortality. Extrathoracic devices that avoid epicardial or
transvenous leads, such as the subcutaneous implantable
cardioverter-defibrillator (S-ICD), can reduce the risk of serious
infection-related complications, such as bloodstream infection and
infective endocarditis. While the 2017 AHA/ACC/HRS guidelines include
recommendations for S-ICD use for patients at high risk of infection,
currently, there are no clinical trial data that address best practices
for the prevention of S-ICD infections. Therefore, an expert panel was
convened to develop consensus on these topics. Methods: An expert
process mapping methodology was used to achieve consensus on the
appropriate steps to minimize or prevent S-ICD infections. Two
face-to-face meetings of high-volume S-ICD implanters and an infectious
diseases specialist, with expertise on cardiovascular implantable
electronic device infections, were conducted to develop consensus on
useful strategies pre-, peri-, and post-implant to reduce S-ICD
infection risk. Results: Expert panel consensus of recommended steps for
patient preparation, S-ICD implantation, and post-operative management
were developed to provide guidance in individual patient management.
Conclusion: Achieving expert panel consensus by process mapping
methodology for S-ICD infection prevention was attainable, and the
results should be helpful to clinicians in adopting interventions to
minimize risks of S-ICD infection.
Genetic analysis of two Iranian patients affected with cystinosis identified a novel CTNS mutation: case report
Authors: sarlaki fatemeh , Morovvati Saeid
Published: January 2022

Two Iranian patients presented in this study was suffering from
cystinosis diagnosed based on their clinical symptoms and laboratory
tests. The variations c.257_258delCT and c.323delA in the CTNS gene
found in them are frameshifts and truncating mutations that affect
product function and result in the signs and symptoms of cystinosis.
Prenatal and postnatal exposure to ambient air pollution and asthma in neonatal jaundice infants
Authors: Chung Hao-Wei , Hung Chih-Hsing , Kuo Fu-Chen , Hsieh Hui-Min , Li Chung-Hsiang , Lin Yi-Ching , Tsao Yu-Hsiang , Wu Huang-Wei
Published: January 2022

Background: Both air pollutants and neonatal jaundice (NJ) have known
effects on childhood asthma, but higher total serum bilirubin (TSB)
level was associated with lung protection. This study aimed to assess
whether prenatal/postnatal exposure to air ambient pollutants is related
to the inception of asthma in NJ infants. Material and methods: A nested
case-control retrospective study of NJ infants was performed on the
Kaohsiung Medical University Hospital Research Database between 2009 and
2019. The average concentration of particulate matter (PM2.5), sulfur
dioxide (SO2), nitric dioxide (NO2) for six months, first and second
years after the birth, and first, second and third trimesters prenatally
were analyzed. The mild and significant NJ infants were categorized as
TSB level < and ≧12 mg/dl, respectively. Asthma was defined as
a diagnosis with medication. The adjusted odds ratio (aOR) and 95%
confidence interval (CI) present the relationship between study periods
and childhood asthma. Results: SO2 and NO2 exposure during prenatal
periods were significantly associated with increased risk of childhood
asthma in mild NJ infants (aOR (95% CI)), SO2: 1.20-1.34 (1.05-1.56);
NO2: 1.06-1.07 (1.01-1.13)). Effects were more pronounced in postnatal
exposure to three ambient air pollutants in mild jaundice infants. (aOR
(95% CI), SO2: 1.33-1.41 (1.14-1.69); NO2: 1.07-1.31 (1.01-1.49;
PM2.5:1.05 (1.00-1.10) Conclusion: Both SO2 and NO2 during prenatal and
postnatal exposure in mild NJ infants were associated with childhood
asthma. Whether taken phototherapy or not, significant NJ infants were
spared by three ambient air pollutants.
EARLY CHILDHOOD ALLERGY LINKED WITH DEVELOPMENT OF ATTENTION DEFICIT HYPERACTIVITY DISORDER AND AUTISM SPECTRUM DISORDER
Authors: Nemet Shay , Asher Ilan , Yoles Israel , Baevsky Tuvia , Sthoeget Zev
Published: January 2022

Background: Previous studies reported controversial results regarding
the association between allergic disorders and ADHD/ASD. The aim of this
article is to investigate whether allergic disorders are associated with
ADHD/ASD in a large cohort of pediatric patients. Methods: A
retrospective study using the pediatric (0-18 year) database (ICD-9-CM
codes) of Clalit Health Services during the years (2000-2018). Diagnosis
of all disorders was made by specialist physicians. Results: 117,022
consecutive non-selective allergic children diagnosed with one or more
allergic disorder (asthma, rhinitis. conjunctivitis, skin, food, or drug
allergy) and 116,968 non-allergic children were enrolled to our study.
The mean follow-up period was 11±6 years. The presence of allergic
disorders in early childhood (mean age of allergic diagnosis 4.5± 4.3
years) in boys as well as in girls, significantly increased the risk to
develop ADHD (O.R 2.45, CI 2.39-2.51; P<0.0001), ASD (O.R
1.17, CI 1.08-1.27; P<0.0001) or both ADHD+ASD (O.R 1.5, CI
1.35-1.79; P<0.0001). Children with more than one allergic
comorbidity revealed a much higher risk. In a multivariable analysis
(adjusted for age at study entry, number of yearly visits and gender)
the risk of allergic children to develop ADHD and ADHD+ASD, but not ASD
alone, remained significantly higher. Conclusion: Allergic disorder in
early childhood significantly increased the risk to develop ADHD, and to
a less extend ASD, in later life.