bluuebunny/crossref_metadata_2025 huggingface dataset:
MapReduce Framework to Improve the Efficiency of Large Scale Item Sets in IoT Using Parallel Mining of Representative Patterns in Big Data
Authors: A Geetha  , Ravindra Changala  , Goda Gangaram  , Dr. Mahesh Kotha
Published: December 2022

With the coming of the time of huge information, individuals can gather rich and various information from a wide assortment of assortment gadgets, like those of the Internet of Things. Information concealed in enormous information is extremely helpful and important. Frequent pattern mining, as a basic method of data mining, is applied to every aspect of society. However, the application of traditional frequent pattern mining methods to big data involves bottlenecks due to the large number of result sets. Such bottlenecks make it challenging to deliver commonsense worth underway and life. We proposed a new approach which involved representative patterns using mining technique. This framework can make the runtime difficult to evaluate in large data environments. Our approach gives best solution for the above gaps with the help of online representative pattern-set parallel-mining algorithm. We used MapReduce framework which performs horizontal segmentation over data bases. Finally, several performance optimization strategies are proposed. As shown by numerous experiments on the actual dataset, the algorithm proposed in this paper improves the time efficiency by one order of magnitude. Several optimization strategies reduce the execution time to varying degrees.
Reprogramming Modernism
Authors: Bognár Melinda
Published: December 2022

The advent of digital not only fosters new possibilities in creation but also in conservation. Architectural preservation evoked in the Modern period, when mimicry, a standard method of creation was paused and the intention to preserve past notations of architecture awakened. Now, what is the future of Modernism in the Digital archive?Digital Modern manifests the revival of this objective with actual tools. Digital proposes a new approach to history and the treatment of the past by keeping all records recallable to the present. Cloud computing proposes timeless history, where previous memory stored in algorithms is available at the level of representation. This essay shows how Modern architectural notations are explicitly inherited by the Computational era and introduce the correlation between typology and digital patterns. The period influenced by the industrial revolution and universal solutions prepared the platform for the current era influenced by the digital revolution.To understand the relationship between the two dominant epochs, this essay relies on the notions of mimicry, rules, models and methods as modes of repetition and creation crosslinked with different stages of technological development in history. This will lead to the understanding how virtual copies create a new chapter in mimesis and provokes a new chronological approach. The research methodology does not follow a linear timeline but builds on simultaneous perspectives of the Digital Modern phenomenon.
Typology of wedding melodies of the village Ostriv, Dubno region, Rivne area
Authors:   Mykola Lysenko Lviv National Music Academy, Kundush Kateryna
Published: December 2022

The article offers studying of the wedding music culture in the village Ostriv of Central Volhyn. The main wedding rites are characterised retrospectively. The music repertoire consists of 112 vocal melodies, recorded by the author from old singers’ individual performance in non-rituals conditions and during the real wedding action. The methodological work of Lviv ethnomusicologist Bohdan Lukanyuk „Melotypol- ogy ladkankas and songs (based on West Polissya and West Volhyn)” are used for de- termining of melotypology of the songs. It was defined the main types are ladkankas, songs and pryspivkas. Keywords: Central Volhyn, Dubno region, Ostriv, vocal folklore, wedding cycle, melotypology.
GÜVENLİK İKLİMİ ALGISI VE İŞTEN AYRILMA NİYETİ İLİŞKİSİ: MADEN SEKTÖRÜNDE BİR ARAŞTIRMA
Authors: GÖKÇE Ahmet , SARI Selçuk
Published: December 2022

Bu araştırmada, insan kaynağının korunmasının yanı sıra, nitelikli işgücü üzerinde örgütte kalma konusunda pozitif bir algı oluşturan, örgütte sağlık, güvenlik ve ergonomi koşullarına verilen önemin bir yansıması olan güvenlik iklimi ile çalışanların işten ayrılma niyetleri arasındaki ilişkinin tespit edilmesi amaçlanmaktadır. Ayrıca demografik faktörler ile güvenlik iklimi algısı ve işten ayrılma niyeti arasındaki ilişkilerin ortaya konulması bir diğer amaç olarak oluşmuştur. Gümüşhane ilinde madencilik sektöründe çalışan 257 kişinin katılımıyla gerçekleştirilen bu araştırmada veri toplama aracı olarak nicel araştırma yöntemlerinden biri olan anket yöntemi kullanılmıştır. Araştırma bulgularına göre güvenlik iklimi algısı ile işten ayrılma niyeti arasında negatif yönlü anlamlı bir ilişki tespit edilmiştir. Ayrıca katılımcılara ait demografik faktörlerden; medeni durum, eğitim düzeyi ve çalışılan birim gibi değişkenler ile güvenlik iklimi ve işten ayrılma niyeti arasında istatistiksel açıdan anlamlı bir fark gözlenmemiştir.
MUSCULOSKELETAL DISORDERS OF HAND IN HEALTHCARE WORKERS: A CROSS-SECTIONAL STUDY
Authors: EYİ İbrahim , BÜYÜKAKINCI Banu Yeşim
Published: December 2022

Musculoskeletal disorders (MSDs) of the hand negatively affect the hand's functionality and lead to long periods of sick leave. MSDs of hand are associated with work absences and productivity loss more than other Musculoskeletal disorders (MSDs). The study aimed to assess the discomfort of hands in healthcare workers (HWs) and the relationship between demographics and discomfort. 217 HWs selected randomly in the Trakya University Hospital from Dec. 2019 to Feb. 2020 participated in this cross-sectional study. The study was carried out through a questionnaire for sociodemographic characteristics and Cornell Hand Discomfort Questionnaires for MSDs. SPSS v.24.0 software was used to analyze the data. The most common discomfort scores were in the right-hand wrist (1.79), right-hand thumb joint, right-hand thumb (1.65), left-hand wrist (0.86), and left-hand (index, middle, half ring) (0.87), and left-hand thumb (0.80) areas respectively. Right-hand discomfort scores were relatively higher than left-hand. While an association was detected between the level of education, years of work, and MSDs of hand, there was no relation with gender, marital status, or profession. The findings from the study indicate MSDs of hand among HWs. Further research is recommended to detect the prevalence and prevention of MSDs of hand on HWs.
STEMI in Immediate Recovery Period from COVID in Resource Limited Setting
Authors:   Department of Internal Medicine, Plains regional Medical center, 2100 N M.L.K Jr Blvd, Clovis, NM, USA., Yanamadala Anusha
Published: December 2022

Data on risk assessment for ST elevation myocardial infarction (STEMI) in the immediate recovery period from COVID is lacking
A Review of Empirical Research on Vertical Mismatch and Field of Study Mismatch in Turkey and Additional Evidence from Their Overlapping Mismatch.
Authors: EGE Ahmet Alper , ERDİL Erkan
Published: December 2022

The aim of this paper is two folds. First, we perform a review of empirical research that report the vertical mismatch and/or field of study mismatch in Turkey. Second, we provide additional evidence from two perspectives which are (i) change in vertical mismatch and field of study mismatch over time and (ii) their overlapping mismatch. Using dataset from Turkish Statistical Institute labor force surveys, we conduct our analyses for two separate target groups, namely vocational and technical high schools and higher education. The main findings are as follows: The incidence of both vertical and field of study mismatch is higher for vocational and technical high schools. Both mismatches increased over time for both target groups. More notably, the rate of increase in higher education is higher than that in vocational and technical high schools. Regarding the overlapping mismatch, we define three mismatch categories, namely mere field of study mismatch, mere overeducation and full-mismatch. We find that 40.6% of employees from higher education and 70.2% of employees from vocational and technical high schools are mismatched by any category.
Parliamentary diplomacy and its importance in the conditions of martial law
Authors: Кaminska N. V.
Published: December 2022

The dynamic constitutional process since the proclamation of independence, taking into account the domestic experience of state-building and law-making, the results of constitutional, parliamentary and other reforms, has contributed to the expansion of functions and powers of parliament, forms of activity. In recent years, parliamentary diplomacy has become more important, structured, and new formats of parliamentary interaction have emerged. The importance of international parliamentary organizations and interparliamentary cooperation has grown due to the importance of developing and protecting universal norms of international law, establishing peace and security, protecting democracy, the rule of law and human rights in the world.

Therefore, the current evolution of inter-parliamentary relations is characterized by the growing role of parliamentary diplomacy, although classical international law did not recognize such cooperation as an institution of diplomatic and consular law. In modern conditions in times of armed conflict, such tools are effective, sometimes the only acceptable compromise ways to resolve conflicts between states, with the participation of interparliamentary organizations, parliamentary assemblies of international organizations.

The importance of parliamentary diplomacy as an element of multisectoral foreign military-political development in the context of Russia’s aggression against Ukraine, the effects of martial law, of course, is growing and its available results are obvious. This leads to further scientific research in this area, broadening horizons and strengthening parliamentary democratic culture.

Key words: parliamentary diplomacy, international interparliamentary cooperation, parliamentarism, Verkhovna Rada of Ukraine, martial law
Agrarian legislation of Ukraine during period of martial law: trends and prospects for development
Authors: Kulynych Р. F.
Published: December 2022

The article examines the main directions of development of agricultural legislation of Ukraine at the beginning of martial law and ways to improve it. It is noted that during the martial law the main directions of agricultural policy and development of agricultural legislation of Ukraine were providing loans to agricultural producers under state guarantees, establishing logistics routes for the sale of agricultural products and maximum simplification of documentation related to food exports and imports of critical imports of commodities for farms rural areas. It is proved that under the martial law the state played an active role in overcoming the crisis in the agricultural sector, taking emergency measures to support agricultural producers and deregulate the legal regulation of agricultural relations through bylaws, which provided a rapid positive effect. In general, the Government has abolished the requirements for obtaining licenses and permits for most of these activities: instead of 600, 50 remain in force. It is very important that the state has not started «dismantling» market legal regulations and replacing them with administrative influence on participants in agrarian relations.At the same time, Ukraine is taking measures at the legislative level to deregulate agrarian relations, which are designed for both the martial law and the postwar period. Thus, on May 12, 2022, the Verkhovna Rada adopted the Law of Ukraine «On Amendments to Certain Laws of Ukraine on Uninterrupted Production and Supply of Agricultural Products during Martial Law», which enshrines those measures of deregulation of economic activity of agricultural producers that proved to be effective. Obviously, national legislation will soon be «supplemented» by other legislative acts of the same direction. The conclusion is substantiated that the development of agrarian legislation of Ukraine in martial law necessitated the development of a new agricultural policy and the formation of its legal framework, in particular: legal incentives for the creation and operation of micro and small agricultural producers, especially farms, which in extreme conditions proved more sustainable, able to adapt to new conditions; legislative support for the reorientation of production and export of raw agricultural products to the supply of finished food products with high added value; development of legal support for land irrigation on the basis of modernization of reclamation systems; initiating the conclusion of an international agreement on guarantees of food security in the world, which would give Ukraine and other food- exporting countries the legal status of guarantors of food security in the world.

Key words: agrarian policy, agrarian legislation, deregulation, food security.
The mechanism of administrative and legal regulation of social relations in the conditions of martial law
Authors: Andriyko Olga
Published: December 2022

The article examines the problems of the mechanism of administrative and legal regulation of social relations in the conditions of martial law. Attention is paid to the current state of research in the theory of law and inиadministrative law of this phenomenon, and it is concluded that the emphasis on the instrumental aspect of the mechanism of administrative-legal regulation leaves its other components neglected. In particular, it is about the subject composition, relationships and interaction that ensure the effectiveness of the mechanism. In the conditions of martial law, the legal regime of martial law operates, which determines the features of the mechanism of administrative and legal regulation, consisting in the mandatory presence of the subject and the imperative method of legal regulation.

Key words: mechanism of legal regulation, mechanism of administrative and legal regulation, legal regime of martial law, instrumental component.
Russia’s war crimes against Ukraine and attempts to conceal them (1939–2022): comparative analysis
Authors: Andrusishin B. І. , Tokarchuk O. V.
Published: December 2022

The article provides a comparative analysis of the methodology for concealing war crimes committed by Russia against Ukraine from the beginning of World War II to the current Russian-Ukrainian war (since 2014); show the similarity of the actions of the Nazi regime of Hitler and the racist regime of Putin in the struggle against the Ukrainian national liberation movement and its leaders in the European context.

The beginning of Russia’s unprovoked war against Ukraine, the horrific atrocities of the Russian army in Bucha, Irpin, Borodyanka, Mariupol and other cities and villages of our country, uncovered in racist areas, confirmed that nothing had changed from Stalin’s punitive occupiers. times, and in many cases it became even more inhumane and cruel, surpassing the atrocities of the Nazis during World War II.

The mass atrocities of the Russian military against civilians, especially women and children, the destruction of maternity hospitals, kindergartens, schools, hospitals, and cultural institutions surpassed the Nazi atrocities of the Nazis during World War II. Today, Russia has acted as a Nazi aggressor not only against Ukraine, but also against the entire Western world. At the same time, the Russian leadership is trying to cover up the traces of their crimes, or shift the blame on the Ukrainians themselves, as in previous years on the Poles, Germans, Finns and others.

The aggression of the Russian Federation against Ukraine is manifested in the use of armed force against the sovereignty, territorial integrity, and political independence of Ukraine. War crimes were committed by representatives of the authorities of the Russian Federation, the leadership of its armed forces, regular troops and military units that are not formally subordinate to the leadership of the armed forces under current law.

Methods of fabricating and disclosing false information and the methodology of Russian lies have a long tradition. The historical parallels between Hitler’s Nazi regime during World War II and modern-day Putin’s Russia, and the answer to the question of whether their crimes are different, clearly show that there is no such difference. After all, Bucha, Mariupol, Irpin and other Russian-occupied towns and villages in eastern and southern Ukraine have shown the true nature, scale and consequences of the racist regime in action.

Key words: Ukrainian national liberation movement, Nazism, racism, war crimes, World War II, Russian-Ukrainian war (since 2014).
The Effect of Disaster Education of Increasing Earthquake Disaster Preparedness : A Narrative Review
Authors: Emaliyawati Etika , Satiadi Didi , Sutini Titin , Jamaludin Hasna Nurul Naafiah , Khofifah Intan Nurul , Manika Laurentza Rikma , Fauziyah Syifa Melya , Siagian Esrha Theresya
Published: December 2022

Aims: Earthquake is a disaster that causes a lot of losses both physically, mentally and the highest cause of death compared to other disasters. This is because public knowledge about management and preparedness in dealing with disasters is lacking, so socialization related to education regarding disaster management due to earthquakes is crucial to be given to the community to minimize losses caused. So there is a need for a literature review related to the implementation of education in disaster management.
Purpose: Conducted a narrative review to determine the effect of disaster education on increasing earthquake preparedness.
Methods: The article search strategy used three databases (Google Scholar, EBSCO, Garuda) which were searched from 2014-2021 in the form of research reports and reviews that discussed the effect of disaster education on increasing earthquake preparedness. with the keywords Education, Earthquake Disaster, Preparedness, Education, Earthquake Disaster, Preparedness in a database search. Then the critical appraisal tools from JBI were carried out. There were six articles that met the inclusion and exclusion criteria set.
Results: Shows that the provision of earthquake disaster preparedness education can be carried out by various methods, including the introduction of school-based disaster risk, with lectures, questions and answers, simulations, demonstrations, and audiovisual techniques.  The several journals above, it shows a significant difference in the form of an increase in results before being given the intervention and after being given the intervention.
Conclusion: Based on the results of the literature review is that there is the effect of disaster preparedness training earthquake with methods of educational disaster on community preparedness. And this educational method can be applied to the community to increase preparedness for earthquake disasters.
CtrA activates the expression of glutathione S-transferase conferring oxidative stress resistance to Ehrlichia chaffeensis
Authors: Liang Qi’an , Yan Jiaqi , Zhang Shuwen , Yang Nan , Li Meifang , Jin Yongxin , Bai Fang , Wu Weihui , Cheng Zhihui
Published: December 2022

Ehrlichia chaffeensis, the causative agent of human monocytic ehrlichiosis (HME), is a Gram-negative obligatory intracellular bacterium, which infects and multiplies in human monocytes and macrophages. Host immune cells produce reactive oxygen species (ROS) to eliminate E. chaffeensis upon infection. E. chaffeensis global transcriptional regulator CtrA activates the expression of GshA and GshB to synthesize glutathione (GSH), the most potent natural antioxidant, upon oxidative stress to combat ROS damage. However, the mechanisms exploited by E. chaffeensis to utilize GSH are still unknown. Here, we found that in E. chaffeensis CtrA activated the expression of glutathione S-transferase (GST) upon oxidative stress, and E. chaffeensis GST utilizes GSH to eliminate ROS and confers the oxidative stress resistance to E. chaffeensis. We found that CtrA bound to the promoter regions of 211 genes, including gst, in E. chaffeensis using chromatin immunoprecipitation coupled to deep sequencing (ChIP-seq). Recombinant E. chaffeensis CtrA directly bound to the gst promoter region determined with electrophoretic mobility shift assay (EMSA), and activated the gst expression determined with reporter assay. Recombinant GST showed GSH conjugation activity towards its typical substrate 2,4-dinitrochlorobenzene (CDNB) in vitro and peptide nucleic acid (PNA) transfection of E. chaffeensis, which can knock down the gst transcription level, reduced bacterial survival upon oxidative stress. Our results demonstrate that E. chaffeensis CtrA regulates GSH utilization, which plays a critical role in resistance to oxidative stress, and aid in the development of new therapeutics for HME.
Prevalence of adverse events during ticagrelor versus clopidogrel treatment and its association with premature discontinuation of dual antiplatelet therapy in East Asian patients with acute coronary syndrome
Authors: Kang Min Gyu , Ahn Jong Hwa , Kim Kyehwan , Koh Jin-Sin , Park Joeng Rang , Hwang Seok Jae , Park Yongwhi , Tantry Udaya S. , Gurbel Paul A. , Hwang Jin-Yong , Jeong Young-Hoon
Published: December 2022

Background

Clinical evidence raises the issues regarding the high risk of adverse events and serious bleeding in East Asian patients receiving standard-dose ticagrelor treatment. We sought to evaluate the association between adverse events and their associations with premature discontinuation of dual antiplatelet therapy (DAPT).

Methods

We enrolled East Asian patients presented with acute coronary syndrome who took DAPT with 90-mg ticagrelor (n = 270) or 75-mg clopidogrel (n = 674). During 1-month treatment, antiplatelet effect was evaluated with the VerifyNow P2Y12 assay, and the occurrence of Bleeding Academic Research Consortium (BARC) bleeding and modified Medical Research Council (mMRC) dyspnea was assessed with the dedicated questionnaire.

Results

During 1-month follow-up, patients on ticagrelor showed the higher risks of bleeding (any BARC type: 45.6% vs. 23.6%; odds ratio [OR], 2.71 and BARC 1 or 2 type: 45.2% vs. 22.1%; OR, 2.90, respectively) and dyspnea (26.3% vs. 13.6%; OR, 2.25) compared with those on clopidogrel. In a receiver-operating characteristics curve analysis to predict bleeding risk, ticagrelor showed a lower cutoff of low platelet reactivity (LPR) (P2Y12 reaction unit [PRU] ≤ 20) than clopidogrel (PRU ≤ 110). Early occurrence of bleeding episode was significantly associated with LPR phenotype (OR, 2.68), not type of P2Y12 inhibitor. In multivariate analysis, type of P2Y12 inhibitor (ticagrelor vs. clopidogrel: OR, 2.19) and bleeding episode (OR, 2.94) were independent predictors for dyspnea occurrence. During 1-year follow-up, DAPT with ticagrelor showed a higher risk of premature discontinuation compared to DAPT with clopidogrel (27.8% vs. 4.7%; adjusted HR, 8.84), which risk appeared frequent during the first month (14.4%) during DAPT with ticagrelor. Early occurrence of bleeding and dyspnea synergistically increased a risk of DAPT non-adherence, irrespective of type of P2Y12 inhibitor.

Conclusion

This analysis is the first evidence to show the different cutoff of low platelet reactivity during the reversible (ticagrelor) versus irreversible P2Y12 inhibitor (clopidogrel). Early occurrence of bleeding and dyspnea is very common during standard-dose ticagrelor treatment in East Asian patients, which show a close association with premature DAPT discontinuation.

Clinical trial registration

[https://www.clinicaltrials.gov], identifier[NCT046 50529].
What can eye movements tell about students’ interpretations of contextual graphs? A methodological study on the use of the eye-mind hypothesis in the domain of functions
Authors: Thomaneck Aylin , Vollstedt Maike , Schindler Maike
Published: December 2022

Introduction

The use of eye tracking (ET) in mathematics education research has increased in recent years. Eye tracking is a promising research tool in the domain of functions, especially in graph interpretation. It promises to gain insights into learners’ approaches and ways of thinking. However, for the domain of functions and graph interpretation, it has not yet been investigated how eye-tracking data can be interpreted. In particular, it is not clear how eye movements may reflect students’ cognitive processes. Thus, in this study, we investigate in how far the eye-mind hypothesis (EMH), which states broadly that what the eye fixates is currently being processed, can be applied to this subdomain. This is particularly true for contextual graphs, whose data originate from real-world situations, and which are of central importance for the development of mathematical literacy. The aim of our research is to investigate how eye movements can be interpreted in the domain of functions, particularly in students’ interpretations of contextual graphs.

Methods

We conducted an exploratory case study with two university students: The students’ eye movements were recorded while they worked on graph interpretation tasks in three situational contexts at different question levels. Additionally, we conducted subsequent stimulated recall interviews (SRIs), in which the students recalled and reported their original thoughts while interpreting the graphs.

Results

We found that the students’ eye movements were often related to students’ cognitive processes, even if indirectly at times, and there was only limited ambiguity in the interpretation of eye movements. However, we also found domain-specific as well as domain-general challenges in interpreting eye movements.

Discussion

Our results suggest that ET has a high potential to gain insights into students’ graph interpretation processes. Furthermore, they point out what aspects, such as ambiguity and peripheral vision, need to be taken into consideration when investigating eye movements in the domain of functions.
Distinct and redundant roles for zebrafish her genes during mineralization and craniofacial patterning
Authors: Stenzel Amanda , Mumme-Monheit Abigail , Sucharov Juliana , Walker Macie , Mitchell Jennyfer M. , Appel Bruce , Nichols James T.
Published: December 2022

The Notch pathway is a cell-cell communication system which is critical for many developmental processes, including craniofacial development. Notch receptor activation induces expression of several well-known canonical targets including those encoded by the hes and her genes in mammals and zebrafish, respectively. The function of these genes, individually and in combination, during craniofacial development is not well understood. Here, we used zebrafish genetics to investigate her9 and her6 gene function during craniofacial development. We found that her9 is required for osteoblasts to efficiently mineralize bone, while cartilage is largely unaffected. Strikingly, gene expression studies in her9 mutants indicate that although progenitor cells differentiate into osteoblasts at the appropriate time and place, they fail to efficiently lay down mineralized matrix. This mineralization role of her9 is likely independent of Notch activation. In contrast, her9 also functions redundantly with her6 downstream of Jagged1b-induced Notch activation during dorsoventral craniofacial patterning. These studies disentangle distinct and redundant her gene functions during craniofacial development, including an unexpected, Notch independent, requirement during bone mineralization.
Does China’s poverty alleviation policy improve the quality of the ecological environment in poverty-stricken areas?
Authors: Ran Rong , Ni Zhengxing , Hua Lei , Li Tingrou
Published: December 2022

Poverty eradication and environmental protection as the two global goals of sustainable development. China’s poverty alleviation policy attempts to achieve green development in poverty-stricken areas by eliminating poverty while also promoting environmental protection. Since the Poverty-stricken counties on the Qinghai-Tibet Plateau also have the dual attributes of ecological degradation and ecological fragility, it is of great significance to study the impact of poverty alleviation policy on their environment. In this research, taking poverty alleviation policy as the entry point, based on panel data and Remote Sensing Ecological Index for poverty-stricken counties on the Qinghai-Tibet Plateau from 2011 to 2019, and using the difference-in-differences (DID) method to verify the impact of policy on environmental quality. The main findings of the study were: 1) The poverty alleviation policy has a significant improvement effect on the ecological environment quality of counties in the Qinghai-Tibet Plateau region, and this conclusion still holds in a series of robustness tests using methods including the changing sample size method and the variable replacement method. Moreover, the policy effect has a certain time lag and its effect persists in the long term; 2) It is mainly due to the increased level of government public expenditure and the easing of government financial pressure that has contributed to the improvement of environmental quality in poverty-stricken areas; 3) Policy heterogeneity suggests that industrial poverty eradication policies are more conducive to promoting synergistic economic and environmental development in poverty-stricken areas.
Can green patents reduce carbon emission intensity?—An empirical analysis based on China’s experience
Authors: Wang Na , Yu Huifang , Shu Yalin , Chen Zhao , Li Tiechen
Published: December 2022

Achieving “peak carbon” and “carbon neutrality” and designing energy conservation and emission reduction policies in China require giving full play to the effect of green technology innovation. This paper uses annual data from 1993 to 2020 in China, including the number of green invention patents and green utility model patents, and tests the long-term and short-term effects of green innovation on carbon emission intensity by constructing an ARDL model. The results show that the effect of green invention patents and green utility model patents on CO2 emission intensity is different. Specifically, green invention patents contribute to reducing carbon emission intensity in the short term but act as a barrier in the long term. Green utility model patents suppress carbon emission intensity in the short and long terms. In addition, adjustment of the industrial structure characterized by “shrinking the secondary sector and developing the tertiary sector” has the most excellent effect on reducing carbon emission intensity in the short term. The relative energy price’s carbon emission reduction effect is weaker than the industrial structure. Foreign direct investment and non-fossil energy consumption increase carbon emission intensity in the short term. In the long term, increasing the proportion of non-fossil energy is crucial to reducing carbon emission intensity. The carbon emission reduction effect of energy price is insignificant, and foreign direct investment is not conducive to carbon emission reduction. Finally, this paper analyzes the policy implications of the empirical results and proposes recommendations for reducing China’s CO2 emission intensity accordingly.
Comprehensive assessment of SARS-CoV-2 antibodies against various antigenic epitopes after naive COVID-19 infection and vaccination (BNT162b2 or ChAdOx1 nCoV-19)
Authors: Lee Jihyun , Lee Dong-Gun , Jung Jin , Ryu Ji Hyeong , Shin Soyoung , Cho Sung-Yeon , Lee Raeseok , Oh Eun-Jee
Published: December 2022

Comprehensive assessment of SARS-CoV-2 antibodies against antigenic epitopes and cross-neutralization on variants is essential to monitor after infection or vaccination. From 32 COVID-19 patients and 40 vaccinated individuals [20 Oxford–AstraZeneca (AZ) and 20 Pfizer–BioNTech (BNT)], 348 serial sera are collected until 40 days after infection and 3 months after homologous booster vaccination. Antibody levels were monitored using a multiplex-bead assay including variant spike antigens, Roche (S1/RBD total) and a surrogate virus neutralization test (GenScript). Anti-S/S1/RBD levels were higher than anti-S2/N levels from 2 weeks after infection and were higher in severe infection (P < 0.05). Vaccination showed highest antibody levels after 1-month booster and had consistently high levels in the order of anti-full S, anti-RBD, anti-S1 and anti-S2. Infection induced higher anti-S2/N levels than prime vaccination (P < 0.05). Three months after BNT/BNT vaccination, antibody levels against S1/RBD and 23 variant antigens were higher than post-infection or AZ groups (P < 0.05). Regarding intraindividual changes from post-prime to post-boost vaccination, boost induced a 1.1- to 3.9-fold increase on multiplex-bead assay, 22.8- to 24.2-fold on Roche assay and 22.8- to 24.2-fold on GenScript assay. Post-prime levels by multiplex-bead assay predicted post-boost levels, but Roche and GenScript results were not predictive in the AZ group. The kinetics of SARS-CoV-2 antibody levels vary depending on the antigenic epitopes, assay kit, disease severity or vaccine type. Assessing seroconversion using multiplex-bead assays may contribute to monitoring the disease course, adjusting vaccination strategies, and accelerating vaccination efficacy.
Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission
Authors: Barrows Brittani M. , Krebs Shelly J. , Jian Ningbo , Zemil Michelle , Slike Bonnie M. , Dussupt Vincent , Tran Ursula , Mendez-Rivera Letzibeth , Chang David , O’Sullivan Anne Marie , Mann Brendan , Sanders-Buell Eric , Shubin Zhanna , Creegan Matt , Paquin-Proulx Dominic , Ehrenberg Philip , Laurence-Chenine Agnes , Srithanaviboonchai Kriengkrai , Thomas Rasmi , Eller Michael A. , Ferrari Guido , Robb Merlin , Rao Venigalla , Tovanabutra Sodsai , Polonis Victoria R. , Wieczorek Lindsay
Published: December 2022

Introduction

Infants acquire maternal antibodies by Fc receptor transcytosis across the placenta during pregnancy. Fc receptors are expressed on immune cells and are important for activation of effector cell functions.

Methods

In this study, we evaluated Fc receptor engagement and ADCC activity of plasma binding antibodies from human immunodeficiency virus-1 (HIV) -infected mothers and to identify factors that may contribute to protection from HIV vertical transmission.

Results

HIV-specific binding and Fc receptor engagement of plasma antibodies varied between mothers by transmission status and infants by infection status. Non-transmitting (NT) mothers and HIV-uninfected infants had antibodies with higher neonatal Fc receptor (FcRn) and FcγR engagement, as compared to transmitting (T) mothers and HIV+ infants, respectively. A significant inverse correlation between plasma antibody FcRn and FcγR engagement was observed for T mothers, but not NT mothers. Conversely, a significant direct correlation was observed between plasma antibody FcRn and FcγR engagement for HIV- infants, but not for HIV+ infants. Consequently, we observed significantly higher plasma antibody ADCC potency and breadth in HIV- infants, as compared to HIV+ infants. However, no differences in overall ADCC potency and breadth were observed between mothers. FcRn-engagement of HIV-specific antibodies in both mothers and infants predicted a lack of vertical transmission of HIV.

Discussion

This study indicates that HIV-uninfected infants acquire HIV-specific antibodies with greater Fc receptor engagement and thus, greater ADCC capacity.
Identification of a new probiotic strain, Lactiplantibacillus plantarum VHProbi® V38, and its use as an oral health agent
Authors: Zhang Jingyan , Duan Zhi
Published: December 2022

Introduction

Probiotics can be used to treat oral diseases such as dental caries, gingivitis, periodontitis, and halitosis.

Methods

This study screened for strains capable of inhibiting Streptococcus mutans,one of the primary pathogenic bacteria responsible for dental caries by agar diffusion in different samples. Strain identification was performed by 16S rDNA sequencing and the API 50CH system. The potential functions of the strains in terms of oral health properties were also tested by agglutination assays, growth inhibition assays, adhesion assays, biofilm removal assays and inhibition of adhesion in human primary gingival epithelial (HPGE) cells assays.

Results

This study identified a probiotic strain from fermented cabbages that has a strong inhibitory effect on Streptococcus mutans. The API 50CH system and 16S rDNA sequencing verified that this was a new strain and it was given the name, Lactiplantibacillus plantarum VHProbi®V38. Agglutination, growth inhibition and adhesion, and biofilm removal tests indicated that L. plantarum VHProbi® V38 inhibited and reduced S. mutans. This probiotic was shown to have a broad antibacterial spectrum, simultaneously inhibiting the growth of periodontal pathogenic bacteria such as Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Fusobacterium nucleatum. After 2 hours of co-cultivation with these pathogens, L. plantarum VHProbi® V38 was able to significantly reduce pathogens adhesion on human primary gingival epithelial (HPGE) cells.

Discussion

These findings suggest that L. plantarum VHProbi® V38 could potentially prevent and treat periodontal diseases caused by these pathogenic bacteria. L. plantarum VHProbi® V38 also adheres strongly to HPGE cells and thus has potential as an oral probiotic. This study describes new methods that can be used to aid the screening and identification of oral probiotics.
Dynamic local metrics changes in patients with toothache: A resting-state functional magnetic resonance imaging study
Authors: Wang Mengting , Tang Xin , Li Bin , Wan Tianyi , Zhu Xuechao , Zhu Yuping , Lai Xunfu , He Yulin , Xia Guojin
Published: December 2022

Objective

To study the dynamic changes of local metrics in patients with toothache (TA, Toothache) in the resting state, in order to further understand the changes of central neural mechanism in patients with dental pain and its effect on cognition and emotion.

Methods

Thirty patients with TA and thirty matched healthy (HC) control volunteers were recruited, and resting-state functional magnetic resonance (rs-MRI) scans were performed on all subjects, and data were analyzed to compare group differences in three dynamic local indices: dynamic regional homogeneity (dReHO), dynamic low-frequency fluctuation amplitude (dALFF) and dynamic fractional low-frequency fluctuation amplitude (dfALFF). In addition, the association between dynamic local metrics in different brain regions of TA patients and scores on the Visual Analog Scale (VAS) and the Hospital Anxiety and Depression Scale (HADS) was investigated by Pearson correlation analysis.

Results

In this study, we found that The local metrics of TA patients changed with time Compared with the HC group, TA patients showed increased dReHo values in the left superior temporal gyrus, middle frontal gyrus, precentral gyrus, precuneus, angular gyrus, right superior frontal gyrus, middle temporal gyrus, postcentral gyrus and middle frontal gyrus, increased dALFF values in the right superior frontal gyrus, and increased dfALFF values in the right middle temporal gyrus, middle frontal gyrus and right superior occipital gyrus (p < 0.01, cluster level P < 0.05). Pearson correlation analysis showed that dReHo values of left precuneus and left angular gyrus were positively correlated with VAS scores in TA group. dReHo value of right posterior central gyrus was positively correlated with HADS score (P < 0.05).

Conclusion

There are differences in the patterns of neural activity changes in resting-state brain areas of TA patients, and the brain areas that undergo abnormal changes are mainly pain processing brain areas, emotion processing brain areas and pain cognitive modulation brain areas, which help to reveal their underlying neuropathological mechanisms. In the hope of further understanding its effects on cognition and emotion.
Case report: Complete response of a bladder cancer patient with multiple hepatic and pelvic metastases treated by nab-paclitaxel combined with sintilimab
Authors: Tao Zhu-lei , Wu Wei , Liang Lin-chun , Pan Jin-feng , Cao Jian-zhou , Jia Xiao-long , Fang Li , Ma Qi
Published: December 2022

This article described a patient with metastatic bladder cancer (mBC) who was successfully treated with nab-paclitaxel plus sintilimab. Localized muscle-invasive bladder cancer (MIBC) was discovered in a 56-year-old man who received radical cystectomy and platinum-based adjuvant chemotherapy. Eleven months after cystectomy, this patient developed numerous hepatic and pelvic metastases and progressed to mBC. The patient was given an anti-PD-1 antibody (sintilimab 200mg, q3w) in combination with Nab-paclitaxel (100mg, qw) for mBC. Complete remission (CR) was achieved after nine cycles of therapy, and the patient had no severe side effects during the treatment. The disease remained in CR after 41 months of follow-up. This case suggests that nab-paclitaxel combined with sintilimab is a safe and effective option in treatment of mBC.
Ecosystem carbon use efficiency in ecologically vulnerable areas in China: Variation and influencing factors
Authors: Liu Zhaogang , Chen Zhi , Yu Guirui , Yang Meng , Zhang Weikang , Zhang Tianyou , Han Lang
Published: December 2022

Ecologically vulnerable areas (EVAs) are regions with ecosystems that are fragile and vulnerable to degradation under external disturbances, e.g., environmental changes and human activities. A comprehensive understanding of the climate change characteristics of EVAs in China is of great guiding significance for ecological protection and economic development. The ecosystem carbon use efficiency (CUEe) can be defined as the ratio of the net ecosystem productivity (NEP) to gross primary productivity (GPP), one of the most important ecological indicators of ecosystems, representing the capacity for carbon transfer from the atmosphere to a potential ecosystem carbon sink. Understanding the variation in the CUEe and its controlling factors is paramount for regional carbon budget evaluation. Although many CUEe studies have been performed, the spatial variation characteristics and influencing factors of the CUEe are still unclear, especially in EVAs in China. In this study, we synthesized 55 field measurements (3 forestland sites, 37 grassland sites, 6 cropland sites, 9 wetland sites) of the CUEe to examine its variation and influencing factors in EVAs in China. The results showed that the CUEe in EVAs in China ranged from -0.39 to 0.67 with a mean value of 0.20. There were no significant differences in the CUEe among different vegetation types, but there were significant differences in CUEe among the different EVAs (agro-pastoral ecotones < Tibetan Plateau < arid and semiarid areas < Loess Plateau). The CUEe first decreased and then increased with increasing mean annual temperature (MAT), soil pH and soil organic carbon (SOC) and decreased with increasing mean annual precipitation (MAP). The most important factors affecting the CUEe were biotic factors (NEP, GPP, and leaf area index (LAI)). Biotic factors directly affected the CUEe, while climate (MAT and MAP) and soil factors (soil pH and SOC) exerted indirect effects. The results illustrated the comprehensive effect of environmental factors and ecosystem attributes on CUEe variation, which is of great value for the evaluation of regional ecosystem functions.
Social engagement revealed by gaze following in third-party observers of simulated social conflict
Authors: Champ Tess M. , Lee SeungHyun , Martin Anne B. , Bolles Cameron M. , Kim Sun Woo , Gothard Katalin M.
Published: December 2022

Humans and non-human primates can allocate visual attention to areas of high interest in their visual field based on the behaviors of their social partners. Allocation of attention is particularly important for third-party observers of social interactions. By following the gaze of interacting individuals, the observer can obtain information about the mental states, emotions, and intentions of others. We presented three adult monkeys (Macaca mulatta) with videos of simulated social interactions and quantified their eye movements to determine which observed behaviors were most conducive to gaze following. Social interactions were simulated by juxtaposing two videos depicting a threatening and an appeasing individual facing each other, with the timing of the facial and bodily displays adjusted to mimic an exchange of social signals. Socially meaningful facial displays combined with full body movements significantly enhanced the probability of gaze following and joint attention. Despite the synthetic nature of these interactions, the facial and bodily displays of the submissive individual elicited significantly more joint-attention than gaze-following saccades, suggesting a preferential allocation of attention to the recipients of threatening displays. Temporal alignment of gaze following and joint attention to the frames of each video showed numerous clusters of significant increases in the frequency of these saccades. These clusters suggest that some videos contained signals that can induce a quasi-automatic redirection of the observer’s attention. However, these saccades occurred only on a fraction of the viewings, and we have documented large inter-individual variations. All viewers produced sequences of joint attention saccades (check-backs) shifting their attention between the two monkeys as though monitoring the simulated emitting-receiving cycle of social signals. These sequences reflect the viewer’s interest in monitoring the ongoing exchange of agonistic and affiliative displays. It appears that in macaque monkeys, the scanpaths of third-party observers of simulated social interactions are informed by social-cognitive processes suggestive of mentalizing.
Systematic review on post-stroke computerized cognitive training: Unveiling the impact of confounding factors
Authors: Fava-Felix Paloma E. , Bonome-Vanzelli Silvia R. C. , Ribeiro Fabiana S. , Santos Flávia H.
Published: December 2022

Background

Stroke is a highly incapacitating disease that can lead to disabilities due to cognitive impairment, physical, emotional, and social sequelae, and a decrease in the quality of life of those affected. Moreover, it has been suggested that cognitive reserve (patients’ higher levels of education or having a skilled occupation), for instance, can promote faster cognitive recovery after a stroke. For this reason, this review aims to identify the cognitive, functional, and behavioral effects of computerized rehabilitation in patients aged 50 years or older who had a stroke, considering cognitive reserve proxies.

Methods

We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis—PRISMA, and performed the search for peer-reviewed randomized controlled trials without a date restriction on CINAHL, LILACS, PubMed, Scopus, and Web of Science databases were chosen.

Results

We screened 780 papers and found 19 intervention studies, but only 4 met the inclusion criteria and shared data. These studies included computerized tools for motor and cognitive rehabilitation in the experimental groups. In all studies, computerized training was combined with other interventions, such as standard therapy, occupational therapy, and aerobic exercises. There were 104 participants affected by ischemic or hemorrhagic stroke, predominantly male (57.69%), and all with cognitive impairment.

Conclusion

Despite a limited number of studies, varied methods and insufficient information available, schooling as a CR proxy combined with high-intensity computerized cognitive training was key to mediating cognitive improvement. The systematic review also identified that the associated ischemic stroke and shorter time of onset for rehabilitation contribute to the cognitive evolution of patients. Findings do not support a greater benefit of computerized cognitive training compared to conventional cognitive therapies.

Systematic review registration

[https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=296193], identifier [CRD42022296193].