bluuebunny/crossref_metadata_2025 huggingface dataset:
Editorial Franciscanum 177
Authors: Bonilla Morales Jaime Laurence
Published: January 2022

Editorial Franciscanum 177
L’écriture, le trauma et la chair
Authors: Poché Fred
Published: January 2022

La présente contribution propose d’étudier la façon dont s’articulent l’histoire singulière d’un philosophe et sa pensée, en nous arrêtant, plus particulièrement, sur deux auteurs d’envergure : Louis Althusser et Jacques Derrida. Ceux-ci, en effet, évoqueront, dans leur autobiographie, des blessures personnelles, voire des traumatismes. À de nombreuses reprises, le premier fut hospitalisé en psychiatrie et le second aborda, très fréquemment, la question la circoncision. Dans la présente étude, il s’agira, en premier lieu, d’appréhender l’articulation entre le nom et le processus de subjectivation au regard de ces deux philosophes d’origine algérienne. Ensuite, l’on s’efforcera de prendre au sérieux la question du trauma afin d’analyser ses effets sur leur pensée. Enfin, en s’appuyant sur leurs productions, l’on regardera dans quelle mesure le « réel » abordé par les deux philosophes fait écho à ce « réel » qui s’invita par effraction dans leur existence.
Combinatorial Synthesis of Sulfonate Derivatives of α/β-Naphthol as Anti-
Oomycete Agents
Authors: Che Zhiping , Tian Yuee , Zhang Song , He Jiaxuan , Sun Di , Guo Xiaolong , Li Yuanhao , Zhu Lina , Guo Yihao , Liu Yibo , Huang Xiaobo , Liu Shengming , Chen Genqiang
Published: January 2022

Background:

Developing new, efficient, and environment-friendly small molecule fungicides
is the key to effectively prevent and control plant pathogenic oomycetes. α/β-Naphthol is
an important raw material for drug synthesis. Due to its special structure, α/β-naphthol and its analogs
possess significant biological activity. The preparation and anti-oomycete activity of novel
sulfonate derivatives based on α/β-naphthol against Phytophthora capsici have not been reported
yet.

Methods:

Thirty-two sulfonate derivatives of α/β-naphthol (4a-p and 5a-p) were prepared. The
structure of all title compounds was identified by 1H NMR, MS, and m.p. The anti-oomycete activity
of 4a-p and 5a-p against P. capsici was determined using the mycelial growth rate method.

Results:

With our ongoing research aimed at the discovery and development of fungicidal agents,
4a-p and 5a-p were designed and synthesized, and their anti-oomycete activity against P. capsici
was evaluated in vitro. Two compounds 4a and 5a were found to have good anti-oomycete activity
against P. capsici, and their corresponding EC50 values were 63.41 and 65.21 mg/L, respectively.

Conclusion:

It has been observed that the substituent R in these derivatives is aliphatic, which is
very important for maintaining their anti-oomycete activity. The results lay a foundation for further
design and development of sulfonate derivatives of α/β-naphthol as fungicidal agents. The structure-
fungicidal activity relationship of α/β-naphthol derivatives is under investigation in our laboratory.
Chemometric Study of the Relative Aggregation Propensity of Position 19
Mutants of Aβ(1-42)
Authors: Zbacnik Nathaniel J. , Manning Mark Cornell , Henry Charles S.
Published: January 2022

Background:

The importance of aromaticity vs. hydrophobicity of the central hydrophobic
core (CHC, residues 17-20) in governing fibril formation in Aβ(1-42) has been the focus of an ongoing
debate in the literature.

Introduction:

Mutations in the CHC (especially at Phe19 and Phe20) have been used to examine the
relative impact of hydrophobicity and aromaticity on the degree of aggregation of Aβ(1-42). However,
the results have not been conclusive.

Methods:

Partial least squares (PLS) modeling of aggregation rates, using reduced properties of a series
of position 19 mutants, was employed to identify the physicochemical properties that had the
greatest impact on the extent of aggregation.

Results:

The PLS models indicate that hydrophobicity at position 19 of Aβ(1-42) appears to be the
primary and dominant factor in controlling Aβ(1-42) aggregation, with aromaticity having little effect.

Conclusions:

This study illustrates the value of using reduced properties of amino acids in conjunction
with PLS modeling to investigate mutational effects in peptides and proteins, as the reduced properties
can capture in a quantitative manner the different physicochemical properties of the amino acid side
chains. In this particular study, hydrophobicity at position 19 was determined to be the dominant property
controlling aggregation, while size, charge, and aromaticity had little impact.
Green Synthesis of Acylhydrazides Involving a Heterocyclic Moiety using
Terminal Dihaloalkanes in Organic Salt Media under Solvent-Free Conditions
Authors: Imanzadeh Gholamhassan , Asgharzadeh Roghayyeh , Soltanzadeh Zahra
Published: January 2022

This paper aimed at investigating the reaction of some acyl hydrazides with different terminal
dibromoalkanes. This investigation revealed that acyl hydrazide by reacting with 1,4 and 1,5-
dibromoalkanes in the presence of DABCO (1,4-diazabicyclo[2.2.2]octane) and TBAB (tetrabutylammonium
bromide) underwent a facile intramolecular N2-double-alkylation to form pyrrolidine
and piperidine ring derivatives under solvent-free conditions. Moreover, the alkylation of acyl hydrazide
with 1,6-dibromohexane as a substrate produced the related N2-mono-alkylated derivatives under
the same conditions. Interestingly, using K2CO3 as the base in this reaction for 1,6-dibromohexane led
to acyl hydrazide containing an azepane ring. Surprisingly, direct alkylation of 4-nitrobenzohydrazide
with 1,2-dibromoethane led to an oxadiazine ring derivative. The product yield was found to be 60-
85% in 6-12 h.
Noninvasive or Invasive Mechanical Ventilation in Oncohematologic Patients
with Acute Respiratory Failure: A Systematic Review and Meta-Analysis
Authors: Barreto Lídia Miranda , Ravetti Cecilia Gómez , Guimarães Nathália Sernizon , Nobre Vandack
Published: January 2022

Background:

Acute respiratory failure (ARF) in oncohematologic subjects is one of the
most common causes of high mortality rates. Noninvasive mechanical ventilation (NIMV) has
arisen as an accessory treatment in this clinical scenario.

Objective:

This study aimed to compare mortality rates and severity of illness associated with
NIMV or invasive mechanical ventilation (IMV) in oncohematologic patients with ARF.

Methods:

A search was conducted in the PubMed, SCOPUS, Cochrane Library, LILACS, Web of
Science, and gray literature databases, published between November 2007 and May 2021.

Results:

Eight studies with a total of 570 patients were included. Patients with good responses to
NIMV showed lower values of the Simplified Acute Physiology Score III (SAPS 3) (range: 42±7
to 53±17) when compared to those intubated following NIMV failure (range: 50±11 to 63.3±17.4)
and those who underwent IMV as the primary ventilator support (range: 64.9±17.5 to 66±17). Similarly,
patients whose NIMV treatment failed and those that initially used IMV had higher baseline
values of Sequential Organ Failure Assessment Score (SOFA) when compared to the group with a
good response to NIMV. ICU mortality ranged from 40% to 68% in NIMV success, 54% to 79%
in NIMV failure, and from 54% to 80% in the group treated with IMV. NIMV therapy had a significant
protective effect on mortality (RR=0.71, 95% CI: 0.53-0.94, p=0.02).

Conclusions:

NIMV use in oncohematologic patients admitted to the intensive care units (ICU)
with ARF was associated with lower mortality. Patients successfully treated in the NIMV group
showed lower values of SOFA and SAPS 3 (Prospero Systematic Review -protocol number:
132770).
Graphitic Carbon Nitride-based Photocatalysts for Environmental
Remediation of Organic Pollutants
Authors: Bhusari Ganesh S. , Abdala Ahmed A. , Umekar Mayuri S. , Bhoyar Toshali , Devthade Vidyasagar , Kapgate Bharat P. , Potbhare Ajay P. , Chaudhary Ratiram G.
Published: January 2022

Graphitic carbon nitride (g-C3N4) is an extraordinary semiconductor photocatalyst (PC),
which transforms solar energy into chemical energy for the photodisintegration of several noxious
organic contaminants into non-toxic derivatives. Polymeric g-C3N4 is a metal-free PC with high
chemical stability, eco-friendly composition, and suitable energy band potential that absorb a significant
portion of the solar spectrum. Despite its outstanding characteristics, g-C3N4 has some limitations,
including low visible light absorption, low surface area, and rapid recoupling of charge carriers.
These limitations over-shaded its proficient efficiency as a PC. The current g-C3N4 related research
focuses on developing g-C3N4 nanocomposites (NCs) with high-surface-area, broad lightabsorbing,
and reduced recombination via physicochemical modifications. This review highlights
the latest developments in the synthesis and application of pristine g-C3N4 and its NCs with inorganic
constituent and nanomaterials. A critical analysis of the strategies to enhance g-C3N4’s photocatalytic
efficiency via excited charge separation and visible light absorption is also presented. Furthermore,
the photocatalytic degradation of organic pollutants (OPs), including dyes, phenol, antibiotics,
and pharmaceutical drugs, is summarized herewith.
A Case of Multiple Sclerosis with Protracted Course of COVID-19
Authors: Hasibi Mehrdad , Asadollahi Marjan , Asadollahi-Amin Ali
Published: January 2022

Background:

We reported a case of multiple sclerosis (MS) with persistent symptomatic
COVID-19, which was complicated by new-appearing severe pneumonia 40 days after disease onset.

Case presentation:

A 38-year-old man with a history of multiple sclerosis referred to our hospital with
fever, shaking chills, cough, and dyspnea. In his history, the patient had developed mild COVID-19
from 40 days ago. After 7 days of disease onset, the COVID symptoms had been subsided partially,
but fatigue, myalgia, intermittent fever, and loss of taste and smell had been continued. In physical
examinations, his oral temperature was 39.4 °C. He had respiratory distress, and his blood oxygen
saturation on the room air was 90%. The spiral chest CT scan was performed, which revealed bilateral
ground-glass and alveolar opacities in favor of COVID-19 pneumonia. The result of the RT-PCR test
for SARS-COV-2 was reported positive subsequently. His current MS medication was rituximab and
he had received the last dose of rituximab two months before developing COVID-19. The patient was
admitted to the COVID ward and put on Remdesivir, subcutaneous interferon-beta1b, and dexamethasone.
He improved gradually and was discharged from the hospital with the favorable condition after
10 days. This patient had a rare protracted disease course. We presumed that prolonged high degree
fever (above 38 °C) in our patient is beyond the diagnosis of the post-COVID-19 syndrome and is
more compatible with persistent infection.

Conclusion:

Although most immunocompromised patients effectively clear SARS-CoV-2 infection,
this case report highlights the risk of persistent infection associated with recurrence of the disease.
Seaweed-based Biofertilizers: A Patent Analysis
Authors: Fatimi Ahmed
Published: January 2022

Background:

Seaweed-based biofertilizers for agriculture are developing rapidly
through the innovation and improvement of used raw materials, formulations, methods,
and processes. This is evident from the increase in the number of patent applications
filed each year in this area of seaweed-based biofertilizer research and development.

Methods:

This study concerns the patentability and patent analysis of seaweed-based biofertilizers
between 2000 and 2020. This form of patent analysis englobes information that
could be used as a reference by researchers in the fields of agriculture, as well as those interested,
especially in biofertilizers. During a search, different keywords and related terms
were used, and patents were searched according to title, abstract, and claims. A detailed
analysis was then given regarding publication year, patent classifications, inventors, applicants,
owners, and jurisdictions. Finally, innovation and improvement of seaweed-based
biofertilizers are proposed.

Results:

1731 patent documents have been found. The analyzed period confirms that China
was ranked first with 1336 patent documents, and 2017 was the year with the maximum
number of patent documents (288).

Conclusion:

The patent classification codes reveal that most of the inventions are intended
for soil conditioners and preparation of fertilizers characterized by biological or biochemical
treatment steps, as well as organic fertilizers containing added bacterial cultures.
Development of Bromfenac Sodium Loaded Pluronic Nanomicelles:
Characterization and Corneal Permeation Study
Authors: Patel Asha , Patel Miral , Saha Nithun , Patel Shruti , Ahlawat Priyanka , Dharamsi Abhay
Published: January 2022

Background:

The Cataract is the leading cause of visual impairment and preventable
blindness worldwide. Cataract removal surgery involves various post-operative complications like
pain and inflammation.

Objectives:

The objective of this study is to screen the polymer concentration as well as optimize the
formulation components to develop the pluronic micelles with nanosized characterization and for enhanced
corneal permeation study.

Methodology:

For optimization, Central Composite design was employed to study the effect of independent
variables, concentration of Pluronic F 127 (X1) and the concentration of Hyaluronic acid (X2)
on chosen responses (Y 1 ) Micelle size, (Y 2 ) Entrapment Efficiency, (Y 3 ) Viscosity. The lyophilised
powder was used for physical characterisation.

Results:

The formulation containing 5%w/v Pluronic F127 and 0.2%w/v Hyaluronic acid was the optimised
composition with micelle size and zeta potential 38.74±4.12nm and -17.6±0.1 mV respectively.
In-vitro drug release was found to be 91.72±1.2 percentage in 8 hours. Surface morphology revealed
micelles were spherical in shape. Ocular irritancy study showed that formulation was safe and
non-irritant. In vitro corneal permeation studies through excised rabbit cornea indicated 1.5 fold increase
in ocular availability without corneal damage compared to an aqueous suspension containing
the same amount of drug in nanomicelles.

Conclusions:

In a nutshell, Pluronic Nanomicelles would be a platform for the delivery of Bromfenac
Sodium.
Adaptation of an In-Person Internship to a Virtual Format for Public Health Undergraduates
Authors: Kernan William D , Basch Corey H
Published: January 2022

The disruption of traditional, in-person learning due to the COVID-19 pandemic necessitated the rapid development and use of revised and novel learning opportunities using a variety of remote instructional methodologies. This viewpoint describes the process used by an undergraduate Public Health program to transition a traditional, in-person, semester-long, 480-hour internship to a virtual-only learning experience guided by the existing student learning outcomes. Working closely with public health professionals at existing internship agencies, alumni from the program, student interns, and program faculty developed a modified virtual internship composed of 6 components. The development of this modified virtual internship model was guided by previous research on the components of successful internships and the elements of high-impact learning practices.
Evaluation of Routine Immunization Coverage in 12- to 23-Month Children in Sarepol Province, 2018: Descriptive Cross-sectional Study
Authors: Karimi Sr Abdul Shakour
Published: January 2022

Background

Afghanistan has the lowest routine immunization coverage, according to the WHO-UNICEF reports. The coverage rate of Penta3 in Iran, India, Pakistan, and Afghanistan are estimated to be 99%, 89%, 75%, and 66%, respectively.

Objective

This study aimed to find the real immunization coverage in urban areas and factors related to vaccinated and unvaccinated 12- to 23-month children, in 2018, in Sarepol province.

Methods

A descriptive cross-sectional study with probability proportional to size (PPS) cluster sampling was conducted and modified for application to surveys of immunization coverage. We selected 30 clusters and randomly selected 7 households from each cluster in the urban setting of Sarepol province. The children’s age was calculated, in months, with respect to the 1st day of the survey. We designed a comprehensive questionnaire, and 210 questionnaires were filled. The data were managed and analyzed in Epi Info v.7.

Results

This survey shows EPI routine coverage for 12- to 23-month children for BCG, Meales-1, Penta1, and Penta3, which were 97.14%, 77.14%, 93.81%, and 83.81%, respectively. A full immunization coverage by gender—80.18% for girls and 71.15% for boys—was reported. The dropout rate of vaccination among Penta1, Penta3, and BCG was 9.27%, and for Measles-1 was 18.90%. Moreover, 2.86% of 12- to 23-month children did not receive any vaccine in these urban areas. Children’s illness, emigration, distant health facilities, and the gaps between the doses were reported by the respondents as the main reasons for incomplete or no vaccination. The valid doses administered for BCG, measles, and Penta3 were calculated to be 93.80%, 71.43%, and 80%, respectively.

Conclusions

It is observed that access and use of immunization services in urban areas have improved because full immunization was 75% compared with the AHS-2018 survey’s 61%. However, there are still many children who have not received any vaccine. High immunization dropout rates could be overcome by creating awareness of the program and of the importance of second and third doses of penta, polio, and measles vaccines. Measles coverage is very low, and we are expecting more outbreaks in urban areas. We therefore suggest that the Ministry of Public Health better enhance awareness and implement measles campaigns.
Religion and Power Comparing Political Landscape in the Religious Conflicts in Poso and Maluku
Authors: Yunanto Sri , Damayanti Angel
Published: January 2022

Indonesia is a pluralistic country inhabited by Muslims, Christians, Catholics, Hindus, Buddhists, and Confucians, with Muslims, hold the majority population. Their adherents live in harmony and tolerance within the democratic political system. However, at the outset of the reform era, Indonesian people suffered from instabilities, conflicts, and terrorism, capitalizing ethnic, tribal, and religious symbols for political objectives such as those in the religious conflicts in Poso and Maluku. This paper seeks to compare the political landscape of the Muslim-Christian conflicts in Maluku and Poso. This research uses a qualitative approach with a comparative method and finds similarities and differences of political factors explaining the conflicts. Its similarities were conflicts amongst social, political, and military leaders at the national and local levels. In addition, they used agent provocateurs to provoke their co-religionists. However, this study found differences in the involvement of student and youth unions in Maluku but not in Poso.
Effectiveness of Employees’ Performance Appraisal in the Nigerian Public Sector: An Empirical Study
Authors: Sakpere Randy Oyovwevotu
Published: January 2022

The study identified types of Performance Appraisal (PA) systems in use in Nigerian public sector, investigated effectiveness of PA systems in the sector and examined factors affecting effectiveness of PA systems in the public sector. Purposive sampling technique was used in selecting top, middle and lower levels staff from the various administrative departments within the selected Ministries, Departments and Agencies (MDAs). The result identified annual review, general performance appraisal, evaluation studies, inventory turnover, performance reviews, 4-block metric reviews, performance improvement plans, employee self-appraisal and 360-degree performance appraisal systems as being used in the Nigerian public sector. However, only annual review, inventory turnover, performance reviews, employee self-appraisal and 360-degree appraisal are fairly effective on paper but not in practice. The finding also identified lack of objectivity, halo error, leniency, central tendency error, recent behavior bias, personal bias (stereotyping), manipulating the evaluation, employee anxiety, shifting standards, overall ratings, horn error, strictness and politicisation of rating as factors hindering effectiveness of the appraisal system in Nigerian Public sector. The study concluded that there are employee appraisal systems in place in the Nigerian Public Sector but they are not effectively implemented.
Local vertex antimagic chromatic number of some wheel related graphs
Authors: Shankar R. , Nalliah M.
Published: January 2022

Let G = (V,E) be a graph of order p and size q having no isolated vertices. A bijection ƒ : E → {1, 2, 3, ..., q} is called a local antimagic labeling if for all uv ∈ E we have w(u) ≠ w(v), the weight w(u) = ∑e∈E(u) f(e) where E(u) is the set of edges incident to u. A graph G is local antimagic if G has a local antimagic labeling. The local antimagic chromatic number χla(G) is defined to be the minimum number of colors taken over all colorings of G induced by local antimagic labelings of G. In this paper, we determine the local antimagic chromatic number for some wheel related graphs.
On multi-symmetric functions and transportation polytopes
Authors: Pariguan Eddy , Sierra V. Jhoan
Published: January 2022

We present a study of the transportation polytopes appearing in the product rule of elementary multi-symmetric functions introduced by F. Vaccarino.
An existence result for a strongly nonlinear parabolic equations with variable nonlinearity
Authors: Ait Hammou Mustapha , Azroul Elhoussine , Lahmi Badr
Published: January 2022

We prove the existence of a solution for the strongly nonlinear parabolic initial boundary value problem associated to the equation ut − div a(x, t, ∇u) + g(x, t, u, ∇u) = f, where the vector field a(x, t, ξ) exhibits non-standard growth conditions.
The Holder continuity of the solutions to quasi-linear system of elliptic partial differential equations with singular coefficients
Authors: Yaremenko Mykola
Published: January 2022

This article establishes the Holder continuity of the solutions to a quasi-linear system of elliptic partial differential equations with singular coefficients under the assumption of its form-boundary.
On a maximal subgroup of the orthogonal group O⁺₈(3)
Authors: Mwanzia Musyoka David , Njuguna Lydia N. , Prins Abraham Love , Chikamai Lucy
Published: January 2022

The orthogonal simple group 0 (3) has three conjugacy classes of maximal subgroups of the form 36:L4(3). These groups are all isomorphic to each other and each group has order 4421589120 with index 1120 in 0 (3). In this paper, we will compute the ordinary carácter table of one of these classes of maximal subgroups using the technique of Fischer-Clifford matrices. This technique is very efficient to compute the ordinary character table of an extension group Ḡ = N.G and especially where the normal subgroup N of Ḡ is an elementary abelian p-group. The said technique reduces the computation of the ordinary character table of Ḡ to find a handful of so-called Fischer-Clifford matrices of Ḡ and the ordinary or projective character tables of the inertia factor groups of the action of Ḡ on N.
Fuzzification of strongly and locally strongly compact spaces
Authors: Sayed O. R. , Kiliçman Kiliçman
Published: January 2022

In this paper, some characterizations of fuzzifying strong compactness are given, including characterizations in terms of nets and presubbases. Several characterizations of locally strong compactness in the framework of fuzzifying topology are introduced and the mapping theorems are obtained.
Super (a, d)-G + e-antimagic total labeling of Gᵤ[Sn]
Authors: Rajkumar S. , Nalliah M , Maheswari G. Uma
Published: January 2022

Let G = (V, E) be a simple graph and H be a subgraph of G. Then G admits an H-covering, if every edge in E(G) belongs to at least one subgraph of G that is isomorphic to H. An (a, d)-H-antimagic total labeling of G is a bijection ƒ : V (G) ∪ E(G) → {1, 2, 3, ..., |V (G)| + |E(G)|} such that for all subgraphs H’ of G isomorphic to H, the H’ weights w(H’) =∑v∈V(H’) f(v) + =∑e∈E(H’) f(e) constitute an arithmetic progression {a, a + d, a + 2d, ..., a + (n − 1)d}, where a and d are positive integers and n is the number of subgraphs of G isomorphic to H. The labeling ƒ is called a super (a, d)-H-antimagic total labeling if ƒ (V (G)) = {1, 2, 3, ..., |V (G)|}. In [9], authors have posed an open problem to characterize the super (a, d)-G+ e-antimagic total labeling of the graph Gu[Sn], where n ≥ 3 and 4 ≤ d ≤ p+q + 2. In this paper, a partial solution to this problem is obtained.
Soil Health Prediction Using Supervised Machine Learning Technique
Authors: Patil Pratiksha
Published: January 2022

Abstract: Agriculture is one of the major fields in India that has been overlooked by technical touch. The application of artificial intelligence derivatives such as machine learning and deep learning to agricultural practises aids in crop production and soil health maintenance. The health of an agricultural field is primarily concerned with the preservation of soil nutrients, such as chemical and physical properties, by properly transmitting supplements. When soil health is managed scientifically, it gradually aids in high yield production and the long life of cultivation land. The soil data collected from soil testing centres is used to build the ontology. Ontology is constructed in such a way that it demonstrates the knowledge and relationship between soil and its chemical nutrients. The knowledge base is then used to connect the nutrient and soil type. Machine learning comes with useful and best-in-class algorithms for managing soil health and classifying it into healthy and unhealthy categories. In this study, obvious machine learning algorithms are used to efficiently classify the soil into two classes: healthy and unhealthy. To classify the data, algorithms such as logistic regression, Decision tree, Random tree classifier, Support Vector Machine, and XGBoost were used, and their algorithmic efficiency was increased through hyper parameter tuning using various techniques. Keywords: Soil health, chemical fertility, Supervised Learning, SVM, Decision Tree, Logistic Regression, Ensemble technique
PERSPECTIVE INSIGHT AND APPLICATION OF IN-SILICO TOOL AS VIRTUAL SCREENING METHOD FOR LEAD DESIGNING AND DEVELOPMENT
Authors: UChikhale Hemant
Published: January 2022

Humans are now in a bioinformatics and chemo informatics century, where we can foresee data across domains like as healthcare, the environmental, technology, and public health. The use of information sharing in silico methodologies has impacted sickness administration by predicting the absorption, distribution, metabolism, excretion, and toxicity (ADMET) patterns of synthetic compounds and efficient and environmentally succeeding pharmaceuticals upfront. The purpose of lead discovery and design is to create the appearance of novel drug candidates that can attach to a specific illness cause. The lead investigative process starts with the recognition of the lead structure, which is followed by the synthesis of its analogs and their estimation in order to produce a candidate for lead improvement. The finding of the proper lead exact is the fundamental and primary worked in the traditional lead discovery progression, and the use of computer (in silico) approaches is widely used in lead innovation. A medicinal chemist's passion for building lead structure is piqued by biomolecules, which are often made up of DNA, RNA, and proteins (such as enzymes, receptors, transporters, and ion channels). The underlying principle of such nuts and bolts is noteworthy to be acquainted with their pharmacological implication to the disease under examination. The motive of this review piece of writing is to emphasize several of the in silico methods that are used in lead discovery and to express the applications of these computational methods.
FORMULATION, DEVELOPMENT AND EVALUATION OF IMMEDIATE RELEASE ROSUVASTATIN CALCIUM TABLET
Authors: Pingale Prashant L.
Published: January 2022

Rosuvastatin belongs to the statin medication class, which is used to treat excessive cholesterol and prevent heart disease. The Biopharmaceutical Classification System classifies it as class II. The goal of this project is to create 10 mg Rosuvastatin instant release pills using several types of materials. To boost the drug's bioavailability, superdisintegrants were used to speed up the disintegration and dissolution of Rosuvastatin calcium. Cited research work aims to formulate an immediate release tablet of Rosuvastatin for the treatment of hypercholesterolemia, hypolipoproteinemia, and atherosclerosis. The present work used a cost-effective wet granulation process to create an immediate release formulation of Rosuvastatin calcium. All of the batches were manufactured, and the granules were evaluated for pre-compression properties such as loss on drying, bulk density, tapped density, and compressibility index. Disintegration time and assay were determined to be within acceptable parameters, as were weight fluctuation, thickness, hardness, and friability of tablets. The effect of several superdisintegrants on in vitro dissolutions in 6.8 PH phosphate buffer was investigated. The final formulation was chosen based on the dissolving profile; dissolution studies revealed that formulations F2 and F4 released 80 percent of the medication within 15 minutes. Two different formulations of Rosuvastatin Calcium 5.199 and 10.398 mg employing immediate-release tablets were successfully generated using Crospovidone, Meglumine, and Comprecel 112D+®. The tablets showed complete drug release in 60 minutes and fair flow characteristics when compared to the innovators' product.
METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF MELATONIN IN TABLET BY USING RP-HPLC
Authors: Jadhav Khanderao Rajaram
Published: January 2022

In the present work new, Simple Reversed-Phase High Performance Liquid Chromatographic method was developed and validated for the estimation of Melatonin in tablets. A sharp peak was obtained 7.125 min using Methanol: Phosphate buffer (PH 3.0) in the ratio of 40:60 as mobile phase at a flow rate of 1.0 ml/min, on HPLC Waters 515 system containing UV detector with Empower software. The separation was achieved on the C18 analytical column (250 mm × 4.6 mm, 5.0 μm). The detection was carried out at 223 nm. The method gave good resolution and suitable retention time. The results of the analysis in this method were validated in terms of specificity, accuracy, precision, linearity, and range. The method was found to be reliable, reproducible, rapid, and economic. The RP-HPLC method developed in this study showed specificity and selectivity with linearity in the working range and good precision and accuracy, making it very suitable for the estimation of Melatonin in tablets.
INVOLVEMENT OF SOME ALLERGENS OF PLANT AND ANIMAL ORIGIN IN ALLERGIC REACTIONS RELATED TO RESPIRATORY SYSTEM
Authors: Dange Hemalata V.
Published: January 2022

In India, the prevalence of allergic responses and bronchial asthma is on the rise, which is a major public health concern. Increased exposure to an allergen, a substance that causes a reaction, can cause allergy sensitization in genetically vulnerable people. Continued exposure to allergens can raise the risk of allergic diseases which can further progress into life threating respiratory diseases. Allergic reactions to a variety of indoor and outdoor allergens play a key role in severe breathing disorders such as asthma and chronic obstructive pulmonary disease (COPD). There are distinctive kinds of allergens like animal proteins and animal dander, pollen, food, fungi, mould, Insects, Bird droppings and many others. The common allergens that cause respiratory difficulties have been identified after an honest effort. A modest retrospective analysis of 160 patients was done. Their medical history was gathered in order to determine whether or not they had been exposed to allergies in the past. All of the study participants were given a Skin prick test (SPT) with a variety of allergens, and their allergy status was evaluated based on the results. Most allergens, such as dust mites, pollen grains, and pigeon droppings, have been discovered to cause severe respiratory allergies, which can lead to life-threatening respiratory complications.
Ease of Doing Business Reforms and Business Growth Among Selected Micro, Small And Medium Enterprises (MSMEs) in Present Day Nigeria: a Hierarchical Multiple Regression Modelling Approach
Authors:   University of Lagos, Olayemi Olufemi Olabode , Okonji Patrick Sunday , Ogbeiwi Martin Osaro
Published: January 2022

This article examines how operators of Micro, Small and Medium Enterprises (MSMEs) in the Lagos, Nigeria perceives the impact of the ease of doing business reforms, as crafted by the Presidential Enabling Business Environment Council (PEBEC) on their businesses. This article utilises the survey approach and the hierarchical linear modelling technique for analysis. Measures of ease of doing business topics used in this study include starting a business, getting credit, getting electricity and registering property. Others are, tax payment, entry and exit of people and construction permits. These components of ease of doing business reforms were analysed from the perception of the MSME operators, with a view to determining the factors to be considered by government for improving the business regulatory environment. Results revealed that whilst operators are confident that the reforms have impacted revenue growth and cost reduction, particularly through getting credit, getting electricity and registering property, the same could not be said for employment generation. From these findings the authors suggest that whilst government may yet find plenty of room to operate in to improve the modalities for starting businesses, tax payment, movement of business persons into and out of the country, and processing of construction permits, MSME operators, just as much as government, still have their bit to do by ensuring that as businesses are empowered, they become more socio-economically responsible
La evolución constitucional del derecho a la libertad de creación artística
Authors: Bravo Velásquez Manuel A.
Published: January 2022

En este artículo pretendemos realizar una revisión respecto a la trayectoria constitucional que ha tenido el denominado “Derecho a la libertad de creación artística”, en la perspectiva que será éste prontamente debatido con ocasión del proceso constituyente. Este análisis comenzará con la que ha sido la tradición constitucional chilena, y cómo por el transcurso de las décadas, la legislación ha realizado su labor en cuanto a comenzar a pulir, desgranar y delimitar este derecho de una forma más perfectible y exacta, en consonancia al mayor desarrollo del catálogo de derechos en el siglo XX y asimismo de las nuevas formas y expresiones del arte en general. Aquí, lo que interesa es el medio de expresión, el canal, soporte, registro, material, acto u acción artística, circunscrita a su desenvolvimiento mediato o inmediato de carácter original, en la perspectiva que como toda expresión susceptible de vanguardia y desarrollo, presenta una continua e irrefrenable evolución, siempre adelanta a la vetusta maquinaria jurídica, la cual, en muchas ocasiones, como se verá, más entorpece o confunde el desenvolvimiento de la voluble esencia de este derecho de rango constitucional.
Analisis Ekspor Pulp dan Kertas Jambi ke China
Authors: Ramadani Miko , Hodijah Siti , Artis Dearmi
Published: January 2022

Abstract                                          

Research purposes for Analyze 1). the development of paper and pulp exports in Jambi; 2). the magnitude of the contribution of the volume of pulp and paper exports to Jambi's total export volume ; 3). factor factors affecting Jambi pulp and paper exports to low prices. The method used in this research is descriptive analysis and quantitative analysis of regresi use multiple by clicking on data in 2002-2017.The results of this study show 1). The average volume of Jambi pulp and paper exports to China amounted to 114,280 tons or increased by 15.26 percent. 2). The average contribution of Jambi's pulp and paper export volume to China to Jambi's total exports was 4.25 percent . 3). Simultaneously the price, exchange rate, and GDP have a significant effect to volume Jambi pulp and paper exports to China. While partially the price does not have a significant effect on volume Jambi pulp and paper exports to China.

Keywords : Pulp, Paper, Price, Exchange Rate, GDP

 

Abstrak

Tujuan penelitian untuk Menganalisis 1). perkembangan ekspor  kertas dan pulp di Jambi; 2). besarnya kontribusi volume ekspor pulp dan kertas terhadap total volume ekspor Jambi; 3). faktor-faktor yang mempengaruhi ekspor pulp dan kertas Jambi ke China. Metode yang digunakan dalam penelitian ini adalah analisis deskriptif dan analisis kuantitatif yaitu analisis regresi berganda dengan menggunakan data tahun 2002-2017. Hasil penelian ini menunjukkan 1). Rata-rata volume ekspor pulp dan kertas Jambi ke China sebesar 114.280 ton atau meningkat sebesar 15,26 persen. 2). Rata-rata kontribusi volume ekspor pulp dan kertas Jambi ke China terhadap total ekspor Jambi sebesar 4,25  persen. 3). Secara simultan harga, kurs, dan GDP berpengaruh signifikan terhadap volume ekspor pulp dan kertas Jambi ke China.Sedangkan secara parsial harga tidak berpengaruh signifikan terhadap volume ekspor pulp dan kertas Jambi ke China.

Kata kunci:Pulp, Kertas,harga, kurs, GDP.
Pengaruh investasi, tenaga kerja dan unit usaha terhadap PDRB industri pengolahan di Provinsi Jambi
Authors: Meisi Rica Citra , Zulfanetti Zulfanetti , Hidayat M. Syurya
Published: January 2022

The research objectives are (1) to know the development and contribution of the manufacturing industry GDP (2) to know the development of investment, labor, and processing industry business units; and (3) knowing the effect of investment, labor and business units on processing industry GDP. The data used in this study are secondary data from the Jambi provincial Central Bureau of Statistics (BPS). To answer these goals, this study uses a type of quantitative descriptive research with an analysis model for the first and second problem using the contribution and development model, while the model for the third problem is multiple linear regression. The results of the study show that (1) the average development of the processing industry GDP in Jambi Province in 2000-2016 was 4.86 percent and its contribution was 12.07 percent; (2) the average investment development is 3.42 percent, the average workforce is 4.74 percent, the average business unit is 2.29 percent; and (3) simultaneously and partially investment, labor and business units significantly influence the GDP of the processing industry in Jambi province.
Keywords: GDP, Investment, Employment, Business units.
Analisis faktor-faktor yang mempengaruhi permintaan kain batik Jambi di Kelurahan Mayang Mangurai Kecamatan Alam Barajo Kota Jambi
Authors: Lestari Anisa Dinda , Zulfanetti Zulfanetti , Hardiani Hardiani
Published: January 2022

The purpose of this study was (1) to analyze consumer characteristics of Jambi batik cloth based on the amount of demand for Jambi batik cloth in Mayang Mangurai Village, Alam Barajo District, Jambi City (2) to analyze the effect of Jambi batik cloth prices, consumer income, and prices of substitute goods on cloth demand. Jambi batik in Mayang Mangurai Village, Alam Barajo District, Jambi City. The method used in this study is a survey method using primary data obtained from questionnaires and direct interviews. The data analysis method used was descriptive and quantitative analysis methods with multiple linear regression analysis. The results of the study indicate that (1) the average age of consumers of Jambi batik cloth in Mayang Mangurai Village is 42 years, the last education average of Jambi batik cloth consumers is S1, the average job of Jambi batik cloth consumers is as a civil servant, the average consumer of Jambi batik cloth has a family of 4 people, and the average income earned by consumers of Jambi batik cloth is Rp.4.240.000 on average per month in a year; and (2) simultaneously and partially independent variables, the price of Jambi batik cloth, consumer income and the price of substitute goods have a significant effect on the demand for Jambi batik cloth in Mayang Mangurai Village, Alam Barajo District, Jambi City.
Keywords: Demand, Price, Income, Price of Substitute Goods
Analisis investasi serta pengaruhnya terhadap kesempatan kerja dan pertumbuhan ekonomi di Indonesia
Authors: Rizki Muhammad , Haryadi Haryadi
Published: January 2022

This study aims to analyze the development of investment, labor, and economic growth in Indonesia during the years 2000-2015 and analyze the effect of investment on labor and economic growth in Indonesia during 2000-2015. This study uses descriptive and quantitative methods. The quantitative descriptive analysis method analyzes the development of investment, labor, and economic growth in Indonesia during 2000-2015 and the independent variable (buy) on the dependent variable (employment opportunities and economic growth). Also, employment opportunities in Indonesia while GDP and economic development in Indonesia continue to increase and partially or individually investment in Indonesia has a significant effect on Indonesia's employment opportunities and economic growth.
 Keywords: Investment, Employment opportunity, Economic growth
REGIONAL IMPLEMENTATION OF THE UNITED NATIONS GLOBAL COUNTER TERRORISM STRATEGY IN WEST AFRICA: ISSUES AND CHALLENGES
Authors: Okon Enoch Ndem , Williams Dodeye Uduak
Published: January 2022

AbstractThe paper discusses issues and challenges marring the regional implementation of the United Nations Global Counterterrorism Strategy in West Africa. It highlights economic, technology and socio-political factors that hinders the effective implementation of the strategy in the subregion which has become the hotbed of global terrorism. The study concludes that ECOWAS has the enabling instruments and institutions to implement the strategy. It therefore recommends the strengthening of existing institutions, enhancement of human security indices, and massive investment in infrastructural facilities, as measures to facilitate the implementation of the strategy in the subregion.                                                     Keywords:     United Nations Global Counterterrorism Strategy, West Africa, Implementation  La Implementación Regional de la Estrategia Global de las Naciones Unidas Contraterrorismo en África Occidental: Los Problemas y Desafíos El documento analiza los problemas y desafíos que obstaculizan la implementación regional de la Estrategia Global de las Naciones Unidas Contraterrorismo en África Occidental. Destaca factores económicos, tecnológicos y sociopolíticos que dificultan la implementación efectiva de la estrategia en la subregión que se ha convertido en el semillero del terrorismo global. El estudio concluye que la ECOWAS tiene los instrumentos y instituciones apropriados que le permiten implementar la estrategia. Por lo tanto, el recomienda el fortalecimiento de las instituciones existentes, la mejora de los índices de seguridad humana y la inversión masiva en instalaciones de infraestructura, como medidas para facilitar la implementación de la estrategia en la subregión. Palabras clave: Naciones Unidas La Estrategia de Contraterrorismo Global, África Occidental, Implementación
THE ENDURING RELEVANCE OF NAVAL POWER: REFLECTIONS ON DEFENCE, SECURITY AND POWER PROJECTION OF SEA FRONTIER
Authors: Oyewole Samuel , Duyile Abiodun
Published: January 2022

The sea/maritime domain is a critical frontier of human exploration and exploitation for food production, transportation, commerce, research, communication, mining, defence, security, power projection and prestige in international system. These made it a frontier of strategic cooperation, competition and conflict. Consequently, the sea has been militarised by littoral states, which have led to the rise of naval powers, across time and space. Naval power is strategically relevant in defence, security and power projection, as evident in its roles in warfare, deterrence, policing, and diplomacy across history. This is even more pronounced during the golden age of naval power, when the roles of the navy were decisive in outcomes of war, territorial defence and conquest, empire building and maintenance, bargaining, industrialisation, commerce and global policing. However, the strategic relevance of naval power has undergone notable changes with the rise of air, nuclear and space powers. Against this background, this article examines the enduring strategic relevance of naval power over the last century, vis-à-vis its challenges and prospects among other instruments of force and frontiers of defence, security and power projection that have emerged.
NEW DAWN OR ETERNAL TWILIGHT?
Authors: Shubin Vladimir
Published: January 2022

The article was prepared within the project "Post-crisis world order: challenges and technologies, competition and cooperation" supported by the grant from Ministry of Science and Higher Education of the Russian Federation program for research projects in priority areas of scientific and technological development (Agreement № 075-15-2020-783).
CHINA E RÚSSIA: A PROJEÇÃO NAVAL DE POTÊNCIAS TERRESTRES
Authors: Visentini Paulo
Published: January 2022

The Russian Federation and China are large land States (the first and fourth, respectively), characterized by their configuration as land powers from a geopolitical perspective. Recently, through its development and extroversion of its economy, China has built a naval power with a world presence. Russia, on the other hand, which lost much of the naval and coastal power that the USSR had, is trying to rebuild its capacity for maritime defense and exploration of the new Arctic Route, but still with limited global projection. By analyzing the recent naval projection of these traditional land powers, the article seeks to discuss the extent to which traditional geopolitics is reaching its zenith and initiating its own overcoming
Presencialidad remota desde la perspectiva estudiantil y docente: un análisis de la División de Educación para el Trabajo de la Universidad Nacional, Costa Rica
Authors: Cerdas-Montano Virginia , González-Sandoval German González-Sandoval , Salas Soto Silvia Elena , Villalobos-Benavides Víctor
Published: January 2022

La educación universitaria se enfrenta a una actualización metodológica ante los cambios suscitados por la crisis sanitaria generada por el virus responsable de la COVID-19, por tal razón desde la División de Educación para el Trabajo en la Universidad Nacional, se busca realizar un análisis del contexto y la mediación pedagógica suscitada a partir del 2020 y desde la perspectiva estudiantil y docente.  Se analizan tres elementos medulares en el marco de un paradigma naturalista desde una metodología exploratoria, para identificar las ventajas y desventajas del trabajo en modalidad presencial remota, así como los posibles ajustes por realizarse en un eventual retorno presencial y la preferencia de modalidad de las personas participantes en este proceso de formación. Respecto a estos tres principales resultados se destacan ventajas señaladas tanto por el estudiantado como por el personal docente, las cuales se presentan a nivel personal, familiar, económico, de calidad de vida y salud, además de aspectos académicos, tal como el desarrollo de habilidades y capacidades para la vida profesional y para la continuidad de proyectos vocacionales, entre otros. Las desventajas se refieren a actividades domésticas, tareas múltiples, condiciones ergonómicas, interacción social y la conectividad. Además, dentro de los eventuales ajustes señalados están las condiciones laborales, la capacidad de adaptación al cambio, a la organización de horarios y de lo económico. El estudio concluye que el impacto del virus responsable de la Covid-19, a mediano y largo plazo, en la vida universitaria es inevitable y sus alcances afectarán la forma de organización institucional, la entrega de la docencia y los vínculos relacionales de sus miembros.