bluuebunny/crossref_metadata_2025 huggingface dataset:
A new Dondice Marcus Er. 1958 (Gastropoda: Nudibranchia) from the Mediterranean Sea reveals interesting insights into the phylogenetic history of a group of Facelinidae taxa
Authors: FURFARO GIULIA , MARIOTTINI PAOLO
Published: February 2020

The diversity of Mediterranean nudibranchs has yet to be thoroughly studied: new species are constantly described, and molecular approaches have revealed some cryptic species. A new facelinid species has been discovered based on specimens collected from the Tyrrhenian Sea (Mediterranean Sea). Integrative results of molecular analyses and of anatomical investigations support the description of Dondice trainitoi sp. nov. The characteristic chromatic body pattern and the black epithelium covering the masticatory jaws allow an unambiguous identification of the new taxon. Preliminary phylogenetic analyses based on multi-locus molecular markers (nuclear H3 gene and mitochondrial markers 16S rDNA and COI) surprisingly revealed paraphyly of the genus Dondice and the need of further studies including more taxa assigned to the currently accepted family Facelinidae. Furthermore, following an integrative taxonomy approach, considerations on the ecological behaviour characterizing most of the species involved in this study provide useful insights for understanding the evolutionary history of this facelinid group.
Nemoura cucurbitata (Plecoptera: Nemouridae), a new stonefly species from Guangxi, China
Authors: MO RAORAO , WANG GUOQUAN , YANG DING , LI WEIHAI
Published: February 2020

A new species of Nemouridae, Nemoura cucurbitata sp. nov., is described from the Maoershan National Natural Reserve of Guangxi Zhuang Autonomous Region of southern China. This new taxon is compared with related congeners.
Tacit Knowledge and Generational Change: The China Factor, Enterprise Development and Malaysian Chinese Family SMEs in Traditional Food Production
Authors: Yew John Lee Kean
Published: February 2020

Southeast Asia with its historical concentration of ethnic Chinese remains an important economic hub encouraging cross-disciplinary inquiries on themes relating to businesses. In industrialising Malaysia, there is little research on their capacity to develop tacit knowledge of the founding generation mostly inherited from China, before starting a business in Malaysia. This assessment of four thriving Malaysian Chinese family SMEs in food production evaluates how a new generational change has innovated their traditional food products. Interestingly, tradition may enable these Malaysian Chinese firms to innovate by building on more reliable knowledge and resources, extensively validated over time, and hence reduce development and utilisation costs. The well-trained second and third generations have been innovating tacit knowledge to elicit strong and positive feelings of ‘Chinese’ identity, increasing the value of new products through R&D by embedding past knowledge and facilitating the legitimacy of innovative functionalities and obtaining market acceptance.
Origin of deep heavy oils in the northwestern Junggar Basin (NW China) and implications for gas migration
Authors: Wang Aiguo , Yi Liping , Xiang Baoli , Li Ji , Fan Changyu , Li Chunyu , Zhou Ni , Wang Yi
Published: February 2020

Whether the northwestern Junggar Basin (NW China) has natural gas potential is an urgent but unresolved question. In this study, we discuss the origin of deep heavy oils (>2900 m) and its implication for gas migration and accumulation, based on a comprehensive investigation into physicochemical and geological properties of hydrocarbons in the northern Zhongguai High. Our results indicate that multiple-episode migration of hydrocarbons created four genetic types of oils and three genetic types of hydrocarbon gases and induced widespread gas washing. Relatively low maturity and gas washing are both responsible for the formation of the deep heavy oils. In detail, the migrating late-stage humic-type gases washed the encountered early stage low-maturity oils. The oil reservoirs lost their light fraction and evolved into heavy oils, which are preserved in the deep layer to the present, while the light-end components continued to migrate upward and accumulated as mixed gas pools or vented out of the system. The spatial distributions pattern of source rocks, heavy oils, and mixed gas clearly indicates the migration pathways of humic-type gases, which otherwise are difficult to define in the study area. Because the gases finally migrate into fault belts, their poor preservation condition likely results in the rare discoveries of gas fields. The favorable exploration targets for gas in the area are expected to be fault traps in fault belts, stratigraphic traps along the pinch-out boundary of the Upper Wuerhe Formation, and, particularly, the deep traps in the Mahu Sag.
From Vicious to Virtuous Paradox Dynamics: The Social-symbolic Work of Supporting Actors
Authors: Pradies Camille , Tunarosa Andrea , Lewis Marianne W. , Courtois Julie
Published: February 2020

The dynamics of paradox can be vicious and virtuous. Facing competing yet interrelated demands, organizational actors may find themselves paralyzed by tensions, embroiled in a vicious cycle, or energized by and thriving amid the friction in a virtuous cycle. While studies offer insights into each type, little is known about how actors move from one to the other. Through an action research study at a multinational company, we investigate shifting paradox dynamics. Our model depicts how organizational actors transition from vicious to virtuous cycle, moving through a cycle break and a cycle reversal. Our collaborative methodology sheds light on how supporting actors can shape the social and symbolic dimensions influencing focal actors’ capacity to shift their patterned responses to paradoxical tensions. Supporting actors, positioned as insiders to the organization but outsiders to the paradox, enable this shift by breaking dysfunctional dynamics, facilitating new responses, and embedding virtuous dynamics in the organization.
Hemodynamic Influences on Vascular Endothelial Biology*
Authors: Nerem Robert M. , Girard Peggy R.
Published: February 2020

The vascular endothelium resides in a unique biomechanical stress environment resulting from the hemodynamics of the system. In vivo studies indicate that there are regional differences in endothelial biology and that this may be due to the influence of the local hemodynamic environment. To investigate this further, cell culture studies have been conducted using well-defined mechanical stress environments. To study flow effects, we have employed a parallel plate chamber in which endothelial cell monolayers are exposed to laminar flow. In such experiments and concomitant with changes in morphology, there are a variety of other alterations in cell function, including a decrease in the rate of cell proliferation for subconfluent monolayers. Changes in cell behavior due to the direct effect of pressure and in cultured cells which are in a cyclical stress field also have been observed. In the recognition/transduction of such a mechanical signal, the pathway may possibly include a membrane event linked to the control of intracellular calcium. It may be that the same signaling mechanisms are involved both in cytoskeletal/shape changes and in the control of the cell's growth program and, in exercising such an influence, hemodynamics may have an important role in the response of the arterial wall to injury and the resulting repair and/or disease processes.
Toxic Mechanisms of the Heart: A Review*
Authors: Combs Alan B. , Acosta Daniel
Published: February 2020

Toxic injury is one of the many ways by which the functional integrity of the heart may become compromised. Any of the subcellular elements may be the target of toxic injury, including all of the various membranes and organelles. Understanding the mechanisms underlying cardiotoxicity may lead to treatment of the toxicity or to its prevention. Doxorubicin and its analogs are very important cancer chemotherapeutic agents that can cause cardiotoxicity. Other agents which are cardiotoxic and which have profound public health implications include the alkaloid emetine in ipecac syrup, cocaine, and ethyl alcohol. The most important cardiotoxic mechanisms proposed for doxorubicin include oxidative stress with its resultant damage to myocardial elements, changes in calcium homeostasis, decreased ability to produce ATP, and systemic release of cardiotoxic humoral mediators from tissue mast cells. Each of the first 3 mechanisms can lead to each of the other 2, and the causal relationships between all of these mechanisms are not clear. New evidence suggests that doxorubicinol, one of the metabolites of doxorubicin may be the moiety responsible for cardiotoxicity. Several other potential mechanisms also have been proposed for doxorubicin. Emetine in ipecac syrup is the first aid treatment of choice for many acute toxic oral ingestions and the alkaloid, itself, is used to treat amebiasis. Cardiotoxicity occurs following chronic exposure, such as occurs therapeutically in amebiasis and with ipecac abuse by bulemics. A number of mechanisms are proposed for emetine cardiotoxicity, but the current mechanistic literature is quite scarce. Cocaine abuse recently has caught the public interest, in particular because of the drug-related sudden deaths of certain athletes. Cocaine can cause hypertension, arrhythmias, and reduced coronary blood flow, each of which can contribute to its lethality. However, it may be possible that cocaine sudden death episodes are more related to hyperthermia and convulsive seizures, rather than to cardiovascular toxicity. Chronic alcohol use leads to dilated cardiomyopathy and failure as part of the general physical degeneration that occurs with alcoholism. Several mechanisms are proposed for the cardiomyopathy, but only 2 things seem clear. The cardiotoxicity is due to an intrinsic effect of alcohol, rather than to malnutrition or co-toxicity, and abstinence is the only effective treatment for the cardiomyopathy. Recent articles indicate that very moderate use of alcohol may be beneficial and protect against cardiovascular-related morbidity. One explanation for these findings seems to be that the non-drinking groups, against whom the moderate drinking comparisons were made, were enriched in former drinkers with significant alcohol-related cardiovascular pathology.
The Endothelial Cytoskeleton: Organization in Normal and Regenerating Endothelium*
Authors: Gotlieb Avrum I.
Published: February 2020

The components of the endothelial cell cytoskeleton that have been shown to be important in maintaining endothelial structural integrity and in regulating endothelial repair include F-actin microfilament bundles, including stress fibers, and microtubules, and centrosomes. Endothelial cells contain peripheral and central actin microfilaments. The dense peripheral band (DPB) consists of peripheral actin microfilament bundles which are associated with vinculin adhesion plaques and are most prominent in low or no hemodynamic shear stress conditions. The central microfilaments are very prominent in areas of elevated hemodynamic shear stress. There is a redistribution of actin microfilaments characterized by a decrease of peripheral actin and an increase in central microfilaments under a variety of conditions, including exposure to thrombin, phorbol-esters, and hemodynamic shear stress. During reendothelialization, there is a sequential series of cytoskeletal changes. The DPB remains intact during the rapid lamellipodia mediated repair of very small wounds except at the base of the lamellipodia where it is splayed. The DPB is reduced or absent when cell locomotion occurs to repair a wound. In addition, when cell locomotion is required, the centrosome, in the presence of intact microtubules, redistributes to the front of the cell to establish cell polarity and acts as a modulator of the directionality of migration. This occurs prior to the loss of the DPB but does not occur in very small wounds that close without migration. Thus, the cytoskeleton is a dynamic intracellular system which regulates endothelial integrity and repair and is modulated by external stimuli that are present at the vessel wall-blood interface.
Arterial Responses to Compromised Blood Flow*
Authors: Langille B. Lowell , Bendeck Michelle P.
Published: February 2020

Chronic decreases in arterial blood flow rates elicit arterial constriction followed by remodeling of the artery wall that entrenches a reduced internal diameter. This adaptive response may provide an important compensatory adaptation to physiological reductions in blood flow, but it may also exacerbate pathologic disorders that compromise tissue perfusion. A capacity to manipulate this response requires a knowledge of the mechanisms that control it. Our studies have shown that the response is endothelium-dependent, and that it is probably initiated by release of a vasoconstrictor. This finding suggests that endothelium-derived agonist(s) are involved. We assessed the potential role of prostanoids, endothelin, and a local vessel wall renin-angiotensin system. All of these assessments yielded negative results. It appears, therefore, that a novel vasoactive substance initiates the adaptive response of arteries to reduced blood flow.
Hyper-realistic Face Masks in a Live Passport-Checking Task
Authors: Robertson David J. , Sanders Jet G. , Towler Alice , Kramer Robin S. S. , Spowage Josh , Byrne Ailish , Burton A. Mike , Jenkins Rob
Published: February 2020

Hyper-realistic face masks have been used as disguises in at least one border crossing and in numerous criminal cases. Experimental tests using these masks have shown that viewers accept them as real faces under a range of conditions. Here, we tested mask detection in a live identity verification task. Fifty-four visitors at the London Science Museum viewed a mask wearer at close range (2 m) as part of a mock passport check. They then answered a series of questions designed to assess mask detection, while the masked traveller was still in view. In the identity matching task, 8% of viewers accepted the mask as matching a real photo of someone else, and 82% accepted the match between masked person and masked photo. When asked if there was any reason to detain the traveller, only 13% of viewers mentioned a mask. A further 11% picked disguise from a list of suggested reasons. Even after reading about mask-related fraud, 10% of viewers judged that the traveller was not wearing a mask. Overall, mask detection was poor and was not predicted by unfamiliar face matching performance. We conclude that hyper-realistic face masks could go undetected during live identity checks.
Insights From African American Older Adults on Brain Health Research Engagement: “Need to See the Need”
Authors: Bardach Shoshana H. , Yarbrough Markeda , Walker Charlene , Alfred Doris L. , Ighodaro Eseosa , Kiviniemi Marc T. , Jicha Gregory A.
Published: February 2020

African Americans (AAs) have an elevated risk of developing dementia, yet are underrepresented in clinical research. This project uses a community-engaged photovoice approach to add to existing understanding of barriers and facilitators to AA participation in Alzheimer’s disease research and identify strategies to enhance engagement. Three AA research advocates served as community facilitators to identify and guide groups of AA adults through an eight to nine session photovoice project. Group sessions involved discussions and sharing of images pertaining to various prompts in the area of brain health and research participation. Sessions were audiotaped and transcribed verbatim. Participants identified three categories of barriers to AA research participation: (a) Mistrust, (b) avoidance and fear of acknowledging problems, and (c) seeing the risks of research but not the need. Participants shared suggestions and approaches for ameliorating each of these barriers. This process revealed unique insights into barriers and opportunities for increasing AA engagement in aging and dementia research.
Personality and Organizational Career Growth: The Moderating Roles of Innovation Climate and Innovation Climate Strength
Authors: Jiang Yifan , Wang Qiong , Weng Qingxiong (Derek)
Published: February 2020

Drawing on trait activation theory, the present study answered the question about who achieves better career development in innovative organizations in the Chinese context. We examined the relationships of Big Five personality traits on organizational career growth while considering the cross-level moderating effects of innovation climate and innovation climate strength. More specifically, we argued that conscientiousness and openness to experience would be more strongly related to organizational career growth at the higher level of innovation climate, and the linkages between all Big Five personality traits and career growth are stronger when innovation climate strength is weaker. Data from 2,415 employees randomly selected from 280 institutions in China support most of the hypotheses. We discussed the theoretical and practical implications as well as the limitations and suggestions for future studies.
Tafida Raqeeb v. Barts NHS Foundation Trust and Others [2019]: Bolstering the argument for mediation
Authors: Benbow David I.
Published: February 2020

The Tafida Raqeeb case comprised both a judicial review and a determination of Tafida’s best interests. The judicial review concerned Barts Health NHS Trust’s (Barts) decision not to permit Tafida’s parents to transfer her to Gaslini Children’s Hospital (GCH) in Genoa, Italy. Barts requested that a judge declare that the proposed transfer was not in Tafida’s best interests. In the High Court, MacDonald J’s ruling on the judicial review element of the case was that Barts had not acted unlawfully. In the best interests determination, MacDonald J deemed that continued treatment was in Tafida’s best interests, hence Tafida’s parents would be permitted to transfer her to GCH. Although medical views of best interests tend to prevail in these types of cases, the Raqeeb case, like other previous cases where judges have found in favour of parents, demonstrates that the best interests test is not designed to override the wishes of parents, as its detractors allege, but is flexible enough to allow judges to weigh competing factors in making a determination. In the Raqeeb case, in the absence of clear evidence regarding pain and suffering, subjective factors were accorded more weight within the balancing exercise. I argue that the best interests test should be retained and that a reform affording parents a ‘right to try’ should not be adopted, as this may prolong the pain and suffering of some infants. Nonetheless, the Raqeeb case demonstrates the lack of dialogue between parents and clinicians, in some cases. It therefore bolsters the argument that mediation should be offered in these types of cases.
The Interactional Relationships Between Credit Risk, Liquidity Risk and Bank Profitability in MENA Region
Authors: Abdelaziz Hakimi , Rim Boussaada , Helmi Hamdi
Published: February 2020

The purpose of this article is to investigate the relationship between credit risk, liquidity risks and bank profitability within the Middle East and North African (MENA) countries. We selected data related to a sample of conventional banks observed during the period 2004–2015 and we performed the Seemingly Unrelated Regression (SUR) method in the empirical section. The overall results suggest that profitability of MENA banks is negatively and significantly sensitive to an increase in credit and/or liquidity risks. This negative effect was confirmed for either the separate or the interaction effects of these two risks. Furthermore, the findings indicate that bank profitability decreases significantly the level of credit and liquidity risks. We also found that the law and order as institutional quality increases the profitability of MENA banks and decreases both credit and liquidity risks.
Resuscitating Private Social Security Accounts: Countering Inequality With Panic and Prevarication
Authors: Miller John
Published: February 2020

This article, originally published in Dollars & Sense: Real World Economics , is being reprinted in New Solutions to bring attention to efforts to privatize, dismantle, and fail to protect and expand the U.S. Social Security system. Social Security is an essential element for protecting the health, safety, and well-being of retired U.S. workers and their family members. This article explains attempts to weaken the system and efforts that can be made to sustain the system. The author asks and responds to the question, “Why then would anyone swap a highly successful Social Security system that provides life insurance as well as disability and retirement benefits for private retirement accounts?”
Corralling Organizational Institutionalism
Authors: Buchanan Sean
Published: February 2020

In this essay, I respond to Alvesson, Hallett, and Spicer’s recent piece focusing on the problems stemming from organizational institutionalism’s unprecedented growth and proliferation. I focus my attention specifically on the current definitional problems in the literature and offer some suggestions for how scholars in the area might address these issues in the future.
Effect of Argatroban Combined With Dual Antiplatelet Therapy on Early Neurological Deterioration in Acute Minor Posterior Circulation Ischemic Stroke
Authors: Zhou Ling-Shan , Li Xiao-Qiu , Zhou Zhong-He , Chen Hui-Sheng
Published: February 2020

There is a lack of studies on anticoagulant plus antiplatelet therapy for acute ischemic stroke. The present study made a pilot effort to investigate the efficacy and safety of argatroban plus dual antiplatelet therapy (DAPT) in patients with acute posterior circulation ischemic stroke (PCIS). We retrospectively collected patients diagnosed with acute PCIS according to inclusion/exclusion criteria. According to treatment drugs, patients were divided into an argatroban plus DAPT group and a DAPT group. The primary efficacy end point was the proportion of early neurological deterioration (END). The primary safety outcome was symptomatic intracranial hemorrhage. All outcomes were compared between the 2 groups before and after propensity score matching (PSM). A total of 502 patients were enrolled in the study, including 35 patients with argatroban plus DAPT and 467 patients with DAPT. There was a higher National Institutes of Health Stroke Scale (NIHSS) score in the argatroban plus DAPT group than the DAPT group before PSM (3 vs 2, P = .017). Compared with the DAPT group, the argatroban plus DAPT group had no END (before PSM: 0% vs 6.2%, P = .250; after PSM: 0% vs 5.9%, P = .298). Argatroban plus DAPT yielded a significant decrease in the NIHSS score from baseline to 7 days after hospitalization, compared with that of the DAPT group before PSM ( P = .032), but not after PSM ( P = .369). No symptomatic intracranial hemorrhage was found in any patient. A short-term combination of argatroban with DAPT appears safe in acute minor PCIS.
Prospective Associations of Child Maltreatment Subtypes With Adult Educational Attainment: Tests of Mediating Mechanisms Through School-Related Outcomes
Authors: Ringle Jay L. , Mason Walter A. , Herrenkohl Todd I. , Smith Gail L. , Stevens Amy L. , Jung Hyunzee
Published: February 2020

This study tests a developmental cascades model in which childhood maltreatment is hypothesized to influence adult educational attainment by increasing attention problems and reducing successful school experiences during adolescence. Two path models tested direct and indirect associations of childhood maltreatment with adult educational attainment. Model 1 used three parent-reported subtypes of childhood maltreatment (physical/emotional abuse, sexual abuse, neglect). Model 2 added an agency-reported measure of childhood maltreatment. Both models detected indirect effects of childhood maltreatment subtypes on adult educational attainment through attention and school discipline problems, poor school engagement, and low extracurricular involvement. Model 2 also detected a direct effect of agency-reported childhood maltreatment on the adult outcome. Regardless of the type of maltreatment or data source used, school factors mediated the associations of childhood maltreatment on adult educational attainment. Promoting school engagement and reducing disciplinary referrals for maltreated youth could improve their educational attainment over the long term.
Effect of physical exercise on the functional capacity of children and adolescents submitted to transplantation of hematopoietic stem cells—A systematic review with meta-analysis
Authors: Martha Bianca Andrade , Vacchi Cindy de Oliveira , Fattori Rafael Ailton , Macagnan Fabrício Edler
Published: February 2020

Previous studies have shown beneficial effects of physical exercise (PE) in adults submitted to hematopoietic stem cell transplantation (HSCT). Conduct a systematic review about the effects of PE on the functional capacity of children and adolescents submitted to HSCT. The studies were searched in the databases MEDLINE (via PubMed), Central Register of Controlled Trials (Cochrane CENTRAL), EMBASE, LILACS, and Evidence Database in Physical Therapy (PEDro) (CRD42018080093). Two independent reviewers performed the article selection, data extraction, and methodological quality assessment. Randomized and nonrandomized clinical trials comparing PE with usual treatment in children and adolescents aged 3–18 years were included. The risk of bias was assessed using the Cochrane Collaboration tool and ROBINS-I tool, and the overall quality of the evidence was determined by the GRADE system. We included three studies with 91 patients. PE improved the functional capacity assessed by the timed up and down stairs test (MD −1.23 [95% CI, 2.27 to −.20, I2 = 0%]), but there was no significant effect in the six-minute walk test (MD 44.63 [95% CI, −20.86 to 110.13, I2 = 83%]). The benefits regarding quality of life and peripheral muscle strength of these individuals were not clearly demonstrated, but positive responses were observed in relation to the analyzed data. None of the studies evaluated the fatigue. The limitations found were the high heterogeneity between studies, as well as the sample size and the low methodological rigor. PE might be favorable to improve the functional capacity of children and adolescents treated with HSCT. However, further studies are needed to clarify the best PE program.
Teaching intercultural competence through heavy metal music
Authors: Guberman Daniel
Published: February 2020

What does it mean to teach intercultural competence? Do we need to travel to “other” places? In what way does content need to reflect the traditions of “other” cultures? How can popular musics inform our teaching of these skills? Drawing on the guidelines in the AAC&U Intercultural Knowledge and Competence VALUE Rubric, I argue heavy metal music can serve as a model for using music to increase students’ intercultural knowledge, competency, and awareness, as well as their ability to critically reflect on issues in their own society, including gender, race, and class. I provide background on the genre and explore why it serves as a useful tool for intercultural learning conversations. In making direct connections between the measures in the VALUE rubric and class activities and concepts, this approach can model how others may incorporate intercultural learning and competencies into a wide range of courses.
Implementación del Modelo Islandés para la Prevención del Uso del Sustancias en Adolescentes
Authors: Kristjansson Alfgeir L. , Mann Michael J. , Sigfusson Jon , Thorisdottir Ingibjorg E. , Allegrante John P. , Sigfusdottir Inga Dora
Published: February 2020

Resumen

Esta es la segunda de una serie de dos partes de artículos sobre el Modelo Islandés de Prevención Primaria del Uso de Sustancias (MIP) en Health Promotion Practice. El MIP es una estrategia comunitaria colaborativa que ha demostrado notable efectividad en reducir el inicio del uso de sustancias entres jóvenes de Islandia en los últimos 20 años. Mientras el primer artículo se enfocó en el contexto de fondo, orientación teórica, evaluación y evidencia de su efectividad, y los cinco principios guías del modelo, este segundo artículo describe los 10 pasos centrales en la implementación práctica. Los pasos 1 a 3 se enfocan en cómo construir y mantener la capacidad comunitaria para la implementación del modelo. Los pasos 4 a 6 se enfocan en cómo implementar un sistema riguroso de recolección de datos, como procesarlos, la diseminación de los datos y la traducción de los hallazgos. Los pasos 7 a 9 están diseñados para enfocar la atención de la comunidad y para maximizar el compromiso comunitario en crear y mantener un medioambiente social en el cual la gente joven progresivamente se hace menos proclive a consumir sustancias, e incluye ejemplos ilustrativos de Islandia. Y el paso 10 se enfoca en la naturaleza iterativa, repetitiva y de largo plazo del MIP y describe un amplio y predecible arco de oportunidades y desafíos relacionados con la implementación. Este artículo concluye con una breve discusión sobre las potenciales variaciones en los factores comunitarios para la implementación.
Optimal management of distance-based location registration using embedded Markov chain
Authors: Seo Ki Ho , Baek Jang Hyun , Eom Chris Soo-Hyun , Lee Wookey
Published: February 2020

In this study, we deal with a Distance-Based Registration with Implicit Registration, which is an enhanced scheme of the Distance-Based Registration in mobile-cellular networks. In comparisons with other Location Registration schemes, various studies on the Distance-Based Registration scheme and performance have been performed. However, a real network hierarchy has not been properly reflected in the performance evaluation of the Distance-Based Registration. To accurately evaluate the registration and paging costs of the Distance-Based Registration, a real network hierarchy should reflect that a mobile network is made up of many Visitor Location Register areas. Furthermore, we use an embedded Markov-Chain model in the Visitor Location Register hierarchy, which can reflect not only the Implicit Registration effect of the outgoing calls of user equipment but also cell staying time of the user equipment that may follow a general distribution. Without consideration of the Visitor Location Register, the paging cost decreases due to a small paging area, but the location registration cost rises because of frequent inter Visitor Location Register. The numerical results according to the various conditions show an accurate evaluation of the Distance-Based Registration performance in a real network hierarchy and the general cell staying time. Generally, the total signaling cost will increase when we consider the Visitor Location Register. However, for more appropriate evaluation of the Distance-Based Registration performance, it is necessary to consider the Visitor Location Register hierarchy.
Alteration of Metal Elements in Radiation Injury: Radiation-Induced Copper Accumulation Aggravates Intestinal Damage
Authors: Zhong Li , Dong Aijing , Feng Yang , Wang Xi , Gao Yiying , Xiao Yuji , Zhang Ji , He Dan , Cao Jianping , Zhu Wei , Zhang Shuyu
Published: February 2020

Ionizing radiation causes damage to a variety of tissues, especially radiation-sensitive tissues, such as the small intestine. Radiation-induced damage is caused primarily by increased oxidative stress in the body. Studies have shown that trace metal elements play an irreplaceable role in oxidative stress in humans, which may be associated with radiation-induced tissue damage. However, the alteration and functional significance of trace metal elements in radiation-induced injury is not clear. In this study, we explored the association between radiation-induced damage and 7 trace metal elements in mouse models. We found that the concentration of zinc and copper in mice serum was decreased significantly after irradiation, whereas that of nickel, manganese, vanadium, cobalt, and stannum was not changed by inductively coupled plasma mass spectrometry. The role of copper in radiation-induced intestines was characterized in detail. The concentration of copper was increased in irradiated intestine but reduced in irradiated heart. Immunohistochemistry staining showed that copper transporter protein copper transport 1 expression was upregulated in irradiated mouse intestine, suggesting its potential involvement in radiation-induced copper accumulation. At the cellular level, the addition of CuCl2 potentiated radiation-induced reactive oxygen species in intestine-derived human intestinal epithelial cell and IEC-6 cells. Moreover, the level of copper in damaged cells may be related to the severity of radiation-induced damage as evidenced by a cell viability assay. These results indicate that copper may be involved in the progression of radiation-induced tissue damage and may be a potential therapeutic target.
Antimicrobial and Antihypercholesterolemic Activities of Pulicaria gnaphalodes
Authors: Naqvi Syed Ali Raza , Shah Syed Muhammad Ali , Kanwal Laiba , Saeed Muhammad , Atta-ul-Haq  , Nisar Jaweria , Nisar Zonaira , Akram Muhammad
Published: February 2020

Multidrug resistance has increased globally in the communities. Bacterial infections associated with health care have weakened the existing antimicrobial therapy and demand the search for alternative therapies. In the present investigation, the medicinal plant Pulicaria gnaphalodes from Quetta, Pakistan, has been screened for antimicrobial potential. In vitro antimicrobial efficacy of P gnaphalodes extracts (methanol and ethanol) was quantitatively evaluated on the basis of zone of inhibition against different bacteria and minimum inhibitory concentration (MIC). In vivo, antihypercholesterolemic activity is determined in different rat groups. The results of the study indicated that the ethanol extract of P gnaphalodes showed maximum zone of inhibition for Bacillus subtilis of 12.1 ± 1.1 mm from all others. The methanol extract showed maximum zone of inhibition for Staphylococcus aureus of 11.9 ± 1.0 mm and rifampicin showed maximum zone of inhibition of 23.1 ± 0.9 mm. The results of ethanol and methanol extract of P gnaphalodes against different bacteria revealed that this plant has greater antimicrobial activity. However, the plant extract shows nonsignificant antihypercholesterolemic activity. The extract of this plant can be utilized as medicine to inhibit several infections caused by some bacterial pathogens found in human body.
Evaluation of minimum quantity lubrication and minimum quantity cooling lubrication performance in hard drilling of Hardox 500 steel using Al2O3 nanofluid
Authors: Duc Tran Minh , Long Tran The , Van Thanh Dang
Published: February 2020

The work in this study presents an experimental evaluation on minimum quantity cooling lubrication based on the Ranque–Hilsch vortex tube and minimum quantity lubrication performance in hard drilling of Hardox 500 steel (49–50 HRC) using coated carbide drills. Al2O3 nanoparticles are suspended in the based fluids including water-based emulsion and rice bran oil to enhance the cooling and lubricating effects. The response variables, consisting of drilling thrust force, surface roughness, surface profile and microstructure, and tool wear, are studied, and the analysis of variance is used for evaluating the input machining parameters under minimum quantity lubrication and minimum quantity cooling lubrication conditions. The results of this article indicate that minimum quantity cooling lubrication using Al2O3 nanofluid provides the better machining performance and gives out better surface quality and lower thrust force compared to minimum quantity lubrication with/without nanofluid and minimum quantity cooling lubrication with pure fluid. Also, based on the optimization results, the validation experiments are conducted to study more on drilling thrust force, chip morphology, and tool wear.
Sleep duration and risk of cardiovascular events: The SAVE study
Authors: Li Jingwei , Zheng Danni , Loffler Kelly A , Wang Xia , McEvoy R Doug , Woodman Richard J , Luo Yuanming , Lorenzi-Filho Geraldo , Barbe Ferran , Tripathi Manjari , Anderson Craig S ,   for the SAVE Investigators
Published: February 2020

Background and aim

Controversy exists regarding cardiovascular risk in relation to sleep duration. We determined sleep duration and major recurrent cardiovascular event associations in patients with obstructive sleep apnoea and established cardiovascular disease.

Methods

Secondary analyses of the international, multicenter, Sleep Apnea Cardiovascular Endpoints trial. Sleep duration was estimated from overnight home oximetry (ApneaLink monitor) used for obstructive sleep apnoea diagnosis. Cox proportional hazards models were used to determine associations of categorized sleep duration (<6 h, 6–8 h (reference), and >8 h) and major cardiovascular outcomes: primary composite of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, and any hospitalization for unstable angina, heart failure, or transient ischemic attack; secondary composite of cardiac and cerebral (stroke/transient ischemic attack) events.

Results

Oximetry-derived sleep duration estimates were available in 2687 participants (mean 61.2 years, 80.9% males) who experienced a total of 436 cardiovascular events over a mean follow-up of 3.7 years. Compared to the reference category, sleep duration was not associated with risk of the primary composite cardiovascular outcome (adjusted hazard ratio (HR) 1.00, 95% confidence interval 0.76–1.33, and HR 1.22, 95% confidence interval 0.98–1.52, for sleep duration <6 and >8 h, respectively). However, long sleep was associated with increased cerebral events (HR 1.67, 95% confidence interval 1.17–2.39; P = 0.005) and stroke alone (HR 1.79, 95% confidence interval 1.22–2.63; P = 0.003).

Conclusions

Long sleep duration is associated with an increased risk of stroke but not cardiac events in obstructive sleep apnoea patients with existing cardiovascular disease.

Clinical trial registration

The trial is registered at ClinicalTrials.gov (NCT00738179).
Polyclonal lymphocytic infiltrate with arachnoiditis resulting from intrathecal stem cell transplantation
Authors: Madhavan Ajay A , Summerfield Dan , Hunt Christopher H , Kim Dong K , Krecke Karl N , Raghunathan Aditya , Benson John C
Published: February 2020

Stem cell treatment outside of studied and approved medical indications can have unforeseen adverse consequences. Here, we present a 74-year-old male that underwent such therapy. The patient presented to our institution with progressive lower extremity weakness and urinary incontinence. He had previously undergone intrathecal stem cell therapy in Moscow, Russia for weakness and fatigue. Magnetic resonance imaging of his thoracic and lumbar spine showed marked enlargement of the cauda equina nerve roots and abnormal mass-like soft tissue involving the thoracolumbar thecal sac. Surgical biopsy of the intrathecal soft tissue showed polyclonal lymphocytic and glial cell proliferation. The patient’s symptoms did not improve with medical treatment or radiation, and he is currently under observation after multidisciplinary evaluation. Our patient’s experience illustrates one of the potential risks of “stem cell tourism” and exemplifies the imaging and histopathologic features of this rare entity. We also compare our patient’s treatment with other similar examples of stem cell treatments in our institution and others. These have had a wide spectrum of results. In some instances, intrathecal stem cells have caused abnormal imaging findings without any associated patient symptoms. In extreme examples, however, stem cell treatments have resulted in central nervous system neoplasms. Our patient’s lesion is quite unique, with only one similar lesion having been previously published.
Cardiovascular event rates increase after each recurrence and associate with poor statin adherence
Authors: Lassenius Mariann I , Toppila Iiro , Bergius Susanne , Perttilä Julia , Airaksinen K E Juhani , Pietilä Mikko
Published: February 2020

Aims

The study evaluated the quality of cardiovascular prevention in real-world clinical practice. The recurrence of up to five cardiovascular events was assessed, as data on recurrence beyond the first event and interindividual variations in event rates past the second event have been sparse. Low-density lipoprotein cholesterol concentrations and lipid-lowering therapy use were investigated.

Methods

This retrospective register-based study included adult patients with an incident cardiovascular event between 2004 and 2016 treated in the hospital district of southwest Finland. Patients were followed for consecutive cardiovascular events or cardiovascular death, low-density lipoprotein cholesterol and statin purchases. The timing of event recurrence was evaluated, and predictive factors were assessed.

Results

A wide interindividual variation in cardiovascular event recurrence was observed, each additional event caused an increased risk, the median time of recurrence decreased from 7 to one year for the second and fifth event. Event rates increased correspondingly from 12 to 43/100 patient-years and were most pronounced in the first years following the previous event. The low-density lipoprotein cholesterol goal (<1.8 mmol/l) was reached by 18% in the year after the event and statin underuse was associated with an increased risk of recurrence. Six months after the index event high intensity statins were used by only 22% of the cohort.

Conclusion

The study provides new perspectives on individual risk assessment showing that event rates are not stable for all patients but increase 1.2–1.9-fold per consecutive event. The underuse of statins and poor adherence support the identification of these patients for intensified multifactorial preventive measures.
Diagnosis of insulinoma in a Maine Coon cat
Authors: Gifford Carol H , Morris Anita P , Kenney Kurt J , Estep J Scot
Published: February 2020

Case summary

A 9-year-old male neutered Maine Coon cat presented with a 6-month history of polyphagia and one recent episode of tremors and weakness. Blood work revealed profound hypoglycemia and results of a paired insulin glucose test were consistent with an insulinoma. Abdominal ultrasound revealed a solitary pancreatic mass, and results of a fine-needle aspirate (FNA) gave further support for the location of the neuroendocrine tumor. After unsuccessful medical management of the hypoglycemia, the mass was surgically removed. Immunohistochemistry confirmed that it was an insulinoma. At the time of writing, the patient had been in clinical remission for 9 months.

Relevance and novel information

Feline insulinomas are rare and there is very little information on their behavior, clinical course and histologic characteristics. This is the first reported case of an insulinoma in a Maine Coon cat and the first to describe results of an ultrasound-guided FNA of the mass. In addition, the progression of disease, histopathology and immunohistochemistry results add to the currently minimal database for feline insulinomas.
Career concerns versus shared values: An empirical investigation
Authors: McKenzie Tom , Rutherford Alasdair C
Published: February 2020

We study the relationship between career concerns and shared values empirically using employee–employer matched data for the United Kingdom and overtime hours as a proxy for hard work. In line with standard career-concerns theory, we find that employees work less overtime the longer they have been with their current employer. We also find that employees who agree strongly with the statement ‘I share many of the values of my organisation’ do roughly 20% more overtime than the rest. Our results suggest the existence of a trade-off between career concerns and shared values. We begin to consider some potential implications of this for employee recruitment as well as for the design of career paths across the private, public and voluntary sectors.
Anxieties of an emerging donor: The Korean development experience and the politics of international development cooperation
Authors: Doucette Jamie
Published: February 2020

This article examines recent knowledge sharing initiatives aimed at promoting South Korea’s development experience as a ‘development alternative’ and questions the coherence of the narratives being shared. Drawing upon an idea first put forward by Anna Tsing , I discuss how South Korea’s development cooperation initiatives occupy a zone of awkward engagement in which multiple meanings of its experience have proliferated and explore the anxieties that this engagement creates for practitioners. In particular, the article finds that practitioner anxiety is informed by a triple set of pressures for Korea to export an alternative development model, extend the overseas activities of domestic businesses, and entertain the ambitions of ruling political blocs. By focusing on questions of anxious engagement and the seemingly strategic ambiguity of knowledge sharing efforts it produces, the article highlights some of the limits and possibilities that shape the promotion of the Korean developmental state as an alternative development model for South–South cooperation and extends the emotional register of literature on emerging donors by questioning discursive claims that privilege empathy and reciprocity as drivers of development cooperation.
The weak magnetic field (WMF) enhances the stimulation of polymyxin B sulfate (POL) on Vibrio qinghaiensis sp.-Q67
Authors: Xu Ya-Qian , Li Kai , Wang Ze-Jun , Liu Shu-Shen
Published: February 2020

Background

The weak magnetic field (WMF) can enhance the ability to remove target pollutants in wastewater, which drives us to consider whether WMF could give rise to the hormesis or not. In our previous study, it was found that polymyxin B sulfate (POL) can induce weak hormesis onVibrio qinghaiensissp.-Q67 (Q67). To this end, we set up four different WMF treatments during Q67 culture and POL exposure process, having no WMF in all cases (NW), adding WMF all the time (AW), exerting WMF only during the bacterial culture (BW), and exerting WMF only in POL exposure period (EW).

Results

It was shown that the concentration–response curves (CRCs) of POL in four WMF treatments at the exposure times of 6, 9, and 12 h are non-monotonic hormetic curves where the maximum stimulative effects (Emin) of POL in BW and EW are obviously larger than those in AW and NW. The maximumEminis 26.8% occurring in EW and 20.7% in BW at 6 h, while the maxEminis 14.6% in NW at 9 h, it means that stimulations of POL in BW and EW are earlier and stronger than those in NW. These findings first indicated that WMF can enhance the hormesis of POL.

Conclusions

This study showed that WMF as a key factor may influence the maximum stimulation effect of hormesis. The characteristic of biphasic (hormetic effect) challenges the traditional classical threshold model that is close to chemical risk assessment. But the mechanism of hormesis even now is inconclusive. WMF as a novelty and neglected factor has the potential to support the further development of hormesis mechanism.
Correction to: Comparative genomics of Alternaria species provides insights into the pathogenic lifestyle of Alternaria brassicae – a pathogen of the Brassicaceae family
Authors: Rajarammohan Sivasubramanian , Paritosh Kumar , Pental Deepak , Kaur Jagreet
Published: February 2020

Following the publication of this article [1], the authors reported that the captions of Figs. 2 and 3 were published in the incorrect order, whereby they mismatch with their corresponding images. The figures are reproduced in the correct sequence with the correct captions in this Correction article. The original article has been corrected.