bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparing EQ-5D-3L and EQ-5D-5L in Measuring the HRQoL Burden of 4 Health Conditions in China
Authors: Tan Yani , Zhang Zhen , Hong Yanming , Yang Zhihao , Luo Nan , Jiang Jie , Li Sha
Published: September 2020

Background: This study was conducted to compare the measurement properties of both the EQ-5D-3L and EQ-5D-5L in quantifying health related quality of life (HRQoL) burden for 4 different health conditions in China.Methods: A total of 500 participants from China were recruited to complete the 3L and 5L questionnaire via Internet. The 3L and 5L were compared in terms of distribution properties, ceiling effects and relative efficiency. Distributions of responses were also examined. Results: Ceiling effects decreased significantly in the 5L in all domains (P＜0.01), especially in the pain/discomfort dimension (relative difference: 43.10%). Relative efficiency suggested that 5L had a higher absolute discriminatory power than the 3L version between perfectly healthy participant and 4 condition groups, especially for the HIV/AIDS group when the 3L results was not significant. 5L also had smoother and less clustered index value distributions. Conclusions: Both the 3L and 5L are demonstrated to be valid HRQoL instruments for quantifying disease burden in China. The 5L system may be preferable to the 3L, as it demonstrated superior performance with respect to lower ceiling effect, better relative efficiency and distributions.
Preclinical Modeling of Chronic Inhibition of the Parkinson’s Disease Associated Kinase LRRK2 Reveals Altered Function of the Endolysosomal System in Vivo
Authors: KLUSS JILLIAN H. , Mazza Melissa Conti , Li Yan , Manzoni Claudia , Lewis Patrick A. , Cookson Mark R. , Mamais Adamantios
Published: September 2020

BackgroundThe most common mutation in the Leucine-rich repeat kinase 2 gene (LRRK2), G2019S, causes familial Parkinson’s Disease (PD) and renders the encoded protein kinase hyperactive. To date, the molecular effects of chronic LRRK2 inhibition have not yet been examined in vivo. MethodsWe evaluated the utility of newly available phospho-antibodies for Rab substrates pT73 Rab10, pS106 Rab12, pT71 Rab29 and LRRK2 autophosphorylation to examine the pharmacodynamic response to acute treatment paradigms with the potent and specific LRRK2 inhibitor, MLi-2, in brain and peripheral tissue in G2019S LRRK2 knock-in mice to define the relative target engagement between brain and LRRK2-enriched peripheral tissues. The molecular effects of 10 days and 10 weeks of chronic in-diet dosing were also evaluated using TMTpro reagents for LC-MS/MS total and phospho- proteomics in brain and kidney tissues. ResultsWe report higher sensitivity of LRRK2 autophosphorylation to MLi-2 treatment and slower recovery in washout conditions compared to Rab GTPases phosphorylation, and we identify pS106 Rab12 as a robust readout of downstream LRRK2 activity across tissues. The downstream effects of long-term chronic LRRK2 inhibition in vivo were evaluated in G2019S LRRK2 knock-in mice by phospho- and total proteomic analyses following an in-diet administration of MLi-2 for 10 weeks. We observed alterations in endolysosomal and trafficking pathways in the kidney that were sensitive to MLi-2 treatment and that we validated biochemically. Furthermore, a subtle but distinct biochemical signature affecting mitochondrial proteins was observed in brain tissue in the same animals that was reverted by kinase inhibition. ConclusionsThis is the first study to examine the molecular underpinnings of chronic LRRK2 inhibition in a preclinical in vivo PD model and highlights cellular processes that may be influenced by therapeutic strategies aimed at restoring LRRK2 physiological activity in PD patients.
The Novel Biomarkers-Based HALP (Hemoglobin, Albumin, Lymphocyte and Platelet)-Prognostic Model for Acute and Subacute Patients with Cerebral Venous Sinus Thrombosis: A Retrospective Cohort Study
Authors: Li Shen , Liu Kai , Gao Yuan , Zhao Lu , Fang Hui , Zhang Rui , Liu Hongbing , Zhao Jiawei , Xia Zongping , Xu Yuming , Song Bo
Published: September 2020

Background and purpose: To evaluate the prognosis values of HALP in acute or subacute cerebral venous sinus thrombosis (CVST), to explore the new prognostic model for CVST.Methods: Consecutive patients who were diagnosed as having acute and subacute CVST were retrospectively investigated. We determined the patients' functional outcomes by modified Rankin Scale (mRS). Multivariate logistic regression analysis was used to assess the relationship between factors and poor functional outcomes. The area under the ROC curve (AUC) was estimated to evaluate the ability of markers and models in predicting clinical prognosis. The prognostic model was presented as nomogram. In addition, the decision curve analysis (DCA) was used to analyze the benefit of this model. Furthermore, survival curves were described by the Kaplan‑Meier analysis. Results: A total of 270 patients were included of which 31 had poor outcome. Multivariable logistic regression analysis demonstrated HALP (OR=0.978, 95%CI: 0.958-0.999, P=0.039) was a protective predictor of outcome. The AUC of HALP was 0.749 (95% CI: 0.633-0.865, P=0.044). DCA demonstrated that this model significantly improved risk prediction at threshold probabilities of CVST at 0 to 85%. Patients with higher HALP (P=0.006) presented higher overall survival rates. Conclusions: HALP may be a potential protective marker in acute and subacute CVST patients. The new prognostic model with HALP had potentially better value for Chinese CVST patients.
Impact of Monetary Policy Uncertainty and Fiscal Policy Uncertainty on CO2 Emissions in the Us
Authors: Anser Khalid , Syed Qasim , Khalid Noreen , Turi Jamshid Ali , Shah Juned Ali
Published: September 2020

The authors have requested that this preprint be removed from Research Square.
WITHDRAWN: A Community-based Survey of Household Food Insecurity and Associated Factors Among 2-6 Years Old Children in the Southeast of Iran
Authors: Amaniyan Sara , sotoudeh Mitra , Dadgar Farhad , Jonoush Mona , Vaismoradi Mojtaba
Published: September 2020

Background: To investigate the status of household food security and factors affecting it among 2-6 years old children in an urban area in the southeast of Iran.Methods: A community-based survey was conducted from September to January 2018 on 450 children aged 2-6 years who were selected using stratified cluster random sampling. They lived in six different areas in an urban area in the southeast of Iran. Data was collected using the U.S. Department of Agriculture Food Security questionnaire and anthropometric measurements. Results: The prevalence of food insecurity among children was 81.7% consisting of 2.6% without hunger, 9.2% with moderate hunger and 96.9% with severe hunger. The weight gains of those children who were in the insecurity group without hunger was 2.63 times lower than those children in the food security group. Also, chances of weight gain in the insecurity group without hunger and in the insecurity group with moderate hunger were less as 1.91 and 1.41 times, respectively.Conclusions: Food insecurity in children aged 2-6 years was influenced by various socio-demographic factors. Therefore, policy-makers should plan for improving the quality of life and health of the children through improving their food security.
Feasibility, Effectiveness, and Safety of Endoscopic Vacuum Therapy for Intrathoracic Anastomotic Leakage Following Transthoracic Esophageal Resection: A Prospective Study
Authors: Zhang Chengcheng Christine , Liesenfeld Lukas , Klotz Rosa , Koschny Ronald , Rupp Christian , Schmidt Thomas , Diener Markus K. , Müller-Stich Beat P. , Hackert Thilo , Sauer Peter , Büchler Markus W. , Schaible Anja
Published: September 2020

BackgroundAnastomotic leakage (AL) in the upper gastrointestinal (GI) tract is associated with high morbidity and mortality rates. Especially intrathoracic anastomotic leakage leads to life-threatening adverse events. Endoscopic vacuum therapy (EVT) for anastomotic leakage after transthoracic esophageal resection represents a novel concept. However, sound clinical data are still scarce. This prospective, single-center study aimed to evaluate the feasibility, effectiveness, and safety of EVT for intrathoracic anastomotic leakage following abdomino-thoracic esophageal resection. MethodsFrom March 2014 to September 2019 259 consecutive patients underwent elective transthoracic esophageal resection. 72 patients (27,8 %) suffered from AL. The overall collective in-hospital mortality rate was 3.9% (n=10). Data from those who underwent treatment with EVT were included. ResultsFifty-five patients were treated with EVT. Successful closure was achieved in 89.1% (n=49) by EVT only. The EVT-associated adverse event rate was 5.4% (n=3): bleeding occurred in one patient, while minor sedation-related adverse events were observed in two patients. The median number of EVT procedures per patient was 3. The procedures were performed at intervals of 3-5 days, with a 14-day median duration of therapy. The mortality rate of patients with AL was 7.2% (n=4). Despite successfully terminated EVT, three patients died because of multiple organ failure, acute respiratory distress syndrome, and urosepsis (5.4%). One patient (1.8%) died during EVT due to cardiac arrest. ConclusionsEVT is a safe and effective approach for intrathoracic anastomotic leakages following abdomino-thoracic esophageal resections. It offers a high leakage-closure rate and the potential to lower leakage-related mortalities.
SARS-CoV-2 spike D614G variant exhibits highly efficient replication and transmission in hamsters
Authors: Mok Bobo , Cremin Conor J. , Lau Siu-Ying , Deng Shaofeng , Chen Pin , Zhang Jinxia , Lee Andrew , Liu HOnglian , Liu Siwen , Ng Timothy Ting-Leung , Lao Hiu-Yin , Lee Eddie Lam-Kwong , Leung Kenneth Siu-Sing , Wang Pui , To Kelvin , Chan Jasper , Chan Kwok-Hung , Yuen Kwok-Yung , Siu Gilman Kit-Hang , Chen Honglin
Published: September 2020

SARS-CoV-2 causes disease varying in severity from asymptomatic infections to severe respiratory distress and death in humans. The viral factors which determine transmissibility and pathogenicity are not yet clearly characterized. We used the hamster infection model to compare the replication ability and pathogenicity of five SARS-CoV-2 strains isolated from early cases originating in Wuhan, China, in February, and infected individuals returning from Europe and elsewhere in March 2020. The HK-13 and HK-95 isolates showed distinct pathogenicity in hamsters, with higher virus titers and more severe pathological changes in the lungs observed compared to other isolates. HK-95 contains a D614G substitution in the spike protein and demonstrated higher viral gene expression and transmission efficiency in hamsters. Intra-host diversity analysis revealed that further quasi species were generated during hamster infections, indicating that strain-specific adaptive mutants with advantages in replication and transmission will continue to arise and dominate subsequent waves of SARS-CoV-2 dissemination.
The Interplay Between Oxidative Phosphorylation and Glycolysis as a Potential Marker of Bladder Cancer Progression in Vitro and in Vivo
Authors: Petrella Greta , Ciufolini Giorgia , Burgio Giusy , Salonia Andrea , Montorsi Francesco , Vago Riccardo , Cicero Daniel Oscar
Published: September 2020

BackgroundUrothelial bladder cancer (UBC) is the most common tumor of the urinary system, the ninth most common cancer worldwide and the one with the most expensive treatment from diagnosis to death. One of the biggest problems related to this disease is the lack of sufficiently accurate markers that can anticipate the progression of the cancer from a low-grade non-muscle invasive to a high-grade muscle invasive UBC. Genomics and transcriptomics have recently added a number of molecular markers to traditional observations based on pathological parameters, which have greatly improved the prediction of risk of recurrence and progression. The inclusion of information from other omics sciences, such as metabolomics, could significantly improve this scenario.MethodsIn this study, we present the metabolic characterization using 1H-NMR of three UBC cell lines representing tumors with low-risk of progression, RT4, high-risk, 5637, and a cell line that shares characteristics with both, RT112. The metabolic profiles were classified by multivariate analysis. To validate the in vitro results, concentrations of two metabolites were measured in vivo in the urine of 91 patients with non-invasive and invasive tumors.ResultsRT4 cells mainly use oxidative phosphorylation to produce ATP and biomass, 5637 cells depend mainly on glycolysis, while RT112 cells show a mixed state with both metabolisms partially activated. The lactate/alanine ratio proved to be the most sensitive marker to the different type of metabolism active in the cells in vitro. By measuring its value in vivo in urine, we have found a two-fold increase among patients with high-grade tumors compared to low-grade ones.ConclusionsOur results reveal for the first time the relative importance of glycolysis and oxidative phosphorylation in the growth and maintenance of different UBC cell lines, and the relationship with their genomic signatures. They suggest that oxidative and non-oxidative metabolic states are primarily related to cell lines with low and high risk of progression, respectively. From this observation and our preliminary in vivo results, it appears that the lactate/alanine ratio in patients' urine is a good candidate to become a new marker to predict the conversion of low-grade tumors into more malignant forms.
m5C regulator-mediated methylation modification patterns and tumor microenvironment infiltration characterization in papillary thyroid carcinoma
Authors: Li Fei , Deng Qingmei , Pang Xiaoxi , Huang Shan , Zhang Jingmiao , Zhu Xiaxia , Chen Hong , Liu Xiuxia
Published: September 2020

BackgroundRecently, immune response modulation at epigenetic level is illustrated in studies, but it is still unclear about the possible function of RNA 5-methylcytosine (m5C) modification in the cell infiltration within tumor microenvironment (TME).MethodsIn this study, the m5C modification patterns from altogether 493 papillary thyroid carcinoma (PTC) samples were assessed completely according to 9 m5C regulators. Afterwards, the modification patterns were correlated with the cell infiltration features in TME. The m5C modification patterns in tumor samples were quantified through the principal component analysis (PCA) algorithms to establish the m5C-score. Moreover, this study mined the signature genes related to the m5C-score, constructed the PTC diagnostic model by the support vector machine (SVM) method, and verified its accuracy based on samples in TCGA and GEO databases. The effects of 5 potential drugs based on the PTC m5C-score model in PTC cells were investigated through in vitro and in vivo assays (i.e., cell counting kit 8 and xenograft model). ResultsA total of 3 different m5C modification patterns were identified, and high differentiation degree was observed in the cell infiltration features within TME under the above 3 identified patterns. It was revealed that, evaluating m5C modification patterns in single tumor samples helped to estimate the stromal activity in TME, expression of immune checkpoint genes, and prognosis for patients. Typically, a low m5C-score, which was reflected in the activated immunity, predicted the relatively favorable prognostic outcome. Few effective immune infiltration was seen in high m5C-score subtype, indicating the dismal patient survival. Finally, this study constructed a diagnostic model using the 10 signature genes highly related to the m5C-score, discovered that the model exhibited high diagnostic accuracy for PTC, and screened out 5 potential drugs for PTC based on this m5C-score model. ConclusionsAccording to findings in the present study, m5C modification exerts an important part in forming the TME complexity and diversity. It is valuable to evaluate the m5C modification patterns in single tumors, so as to enhance our understanding towards the infiltration characterization in TME and to better guide clinical diagnosis as well as immunotherapies.
COVID-19 Impact on Neurology Training Program in Italy
Authors: Francesco Di Lorenzo , Tommaso Ercoli , Luca Cuffaro , Francesco Barbato , Francesco Iodice , Gioacchino Tedeschi , Alessandro Bombaci
Published: September 2020

The ongoing COVID-19 pandemic is having a huge impact on clinical activity of all hospitals, including the ones involved in training of residents. In addition, neurology residents underwent substantial modifications of their training program.Aim of our investigation was to evaluate the impact of COVID-19 pandemic on the educational activities of Italian neurology residents through an online questionnaire delivered to neurology residents.The results obtained showed that almost 30% of the respondents were redistributed to COVID-19 units. Neurology departments underwent substantial modifications of their organization influencing clinical educational activities; lessons and seminars were rescheduled online and research protocols were stopped and transferred to remote working, when feasible. There was a relevant use of telemedicine approach even if most of the respondents had never been trained before. Some of the changes had a North-South gradient, following the epidemiology of the pandemic.The data obtained from our survey highlight those points to address to be prepared for possible future emergencies.
Retraction Notice: Phytochemicals from Plants to Combat Cardiovascular Disease
Authors: Vasanthi Hannah R , Mal Nitin ShriShri , Das Dilip Kumar
Published: September 2020

The article entitled “Phytochemicals from Plants to Combat Cardiovascular Disease”, by Hannah R. Vasan-thi, Nitin ShriShri Mal, Dilip Kumar Das, published in Curr. Med. Chem. 2012; 19(14): 224251. https://www.eurekaselect.com/97287/article has been retracted on a complaint of plagiarism with a previously pub-lished article entitled “Resveratrol in cardiovascular health and disease” in the journal Annals of the New York Academy of Sciences as Ann N Y Acad Sci . 2011 Jan;1215:22-33. doi: 10.1111/j.1749-6632.2010.05843.x

The authors were informed of this complaint and were requested to give justification on the matter, in their de-fence. However, no reply was received from them in this regard.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php.
Repurposing of the PDE5 Inhibitor Sildenafil for the Treatment of Persistent Pulmonary Hypertension in Neonates
Authors: Poitras Erika L. , Gust Stephen L. , Kerr Paul M. , Plane Frances
Published: September 2020

Nitric oxide (NO), an important endogenous signaling molecule released from vascular
endothelial cells and nerves, activates the enzyme soluble guanylate cyclase to catalyze
the production of cyclic guanosine monophosphate (cGMP) from guanosine triphosphate.
cGMP, in turn, activates protein kinase G to phosphorylate a range of effector proteins in
smooth muscle cells that reduce intracellular Ca2+ levels to inhibit both contractility and proliferation.
The enzyme phosphodiesterase type 5 (PDE5) curtails the actions of cGMP by hydrolyzing
it into inactive 5’-GMP. Small molecule PDE5 inhibitors (PDE5is), such as sildenafil,
prolong the availability of cGMP and therefore, enhance NO-mediated signaling.
PDE5is are the first-line treatment for erectile dysfunction but are also now approved for the
treatment of pulmonary arterial hypertension (PAH) in adults. Persistent pulmonary hypertension
in neonates (PPHN) is currently treated with inhaled NO, but this is an expensive option
and around 1/3 of newborns are unresponsive, resulting in the need for alternative approaches.
Here the development, chemistry and pharmacology of PDE5is, the use of sildenafil for erectile
dysfunction and PAH, are summarized and then current evidence for the utility of further
repurposing of sildenafil, as a treatment for PPHN, is critically reviewed.
Covid-19 Susceptibility and Severity Might be Modified by Vitamin D Status: Theoretical and Practical Considerations
Authors: Tanner Alex , Tiwari Divya , Allen Stephen
Published: September 2020

Background:

The recently identified SARS-CoV-2 coronavirus has resulted in the
Covid-19 pandemic with severe morbidity and high mortality, particularly in certain sections of the
population. The co-morbidity patterns associated with adverse outcomes are multiple and complex
and there is emerging epidemiological, nutritional and molecular biological evidence that an inadequate
vitamin D status is a contributing factor.

Objective:

The aim was to review the role of vitamin D in immune function with particular reference
to the mechanisms whereby it supports immune efficiency, host protection and immune modulation.
The evidence for the possible benefit of vitamin D supplementation to ameliorate the severity
of respiratory infection by SARS-CoV-2 and other pathogens was also reviewed with a view to
making a recommendation.

Methods:

PubMed, MEDLINE and Google Scholar were searched using the terms: Covid-19, coronavirus,
SARS-CoV-2, vitamin D, calcitriol, deficiency, adaptive immunity, innate immunity, ventilation,
critical care, intensive care, acute respiratory distress syndrome, cytokine storm, respiratory
viruses, respiratory tract infection, respiratory syncytial virus, influenza, supplementation. Papers
for inclusion were selected on the basis of relevance and quality.

Findings:

Vitamin D insufficiency is widespread in many parts of the world. Vitamin D is needed
for normal protective and surveillance immune function and there is evidence that deficiency increases
the risk of some respiratory infections, probably including Covid-19. By binding with dedicated
receptors on immune cells vitamin D influences several strands of immune function, including
the production of anti-microbial peptides and several cytokines that promote an appropriate immune
response. Vitamin D supplementation probably reduces the risk of respiratory infection, with
persuasive biological, epidemiological and observational evidence for possible benefit against
Covid-19.

Conclusion:

Despite the lack of direct evidence specific to Covid-19 a cogent theoretical case can
be made for giving adults from selected groups, and arguably all adults, routine supplementation
with vitamin D to improve immune efficiency and reduce the incidence and severity of respiratory
infections. This could be particularly important in sections of the population with a high prevalence
of vitamin D insufficiency. Targeted research is required to provide firm evidence to guide practice.
Prediction of Shear Strength of Soil Using Direct Shear Test and Support Vector Machine Model
Authors: Ly Hai-Bang , Pham Binh Thai
Published: September 2020

Background:

Shear strength of soil, the magnitude of shear stress that a soil can maintain, is an important factor in geotechnical engineering.

Objective:

The main objective of this study is dedicated to the development of a machine learning algorithm, namely Support Vector Machine (SVM) to predict the shear strength of soil based on 6 input variables such as clay content, moisture content, specific gravity, void ratio, liquid limit and plastic limit.

Methods:

An important number of experimental measurements, including more than 500 samples was gathered from the Long Phu 1 power plant project’s technical reports. The accuracy of the proposed SVM was evaluated using statistical indicators such as the coefficient of correlation (R), Root Mean Squared Error (RMSE), Mean Absolute Error (MAE) over a number of 200 simulations taking into account the random sampling effect. Finally, the most accurate SVM model was used to interpret the prediction results due to Partial Dependence Plots (PDP).

Results:

Validation results showed that SVM model performed well for prediction of soil shear strength (R = 0.9 to 0.95), and the moisture content, liquid limit and plastic limit were found as the three most affecting features to the prediction of soil shear strength.

Conclusion:

This study might help in quick and accurate prediction of soil shear strength for practical purposes in civil engineering.
Efecto de un medio filtrante de arena común y carbón activado sobre la calidad del agua para uso de las tropas del Ejército Nacional de Colombia en el área de operaciones
Authors: Agudelo García Edgar , Reinoso Marroquín Dagoberto , Ríos Molano Walter Andrés , Blanco Londoño Sergio Andrés
Published: September 2020

El consumo de agua contaminada en el área de operaciones ha generado enfermedades de origen hídrico en las tropas del Ejército Nacional de Colombia (EJC). Esta investigación describe el efecto en la calidad del agua del medio filtrante de un filtro portátil de arena común y carbón activado, el cual puede ser transportado por las tropas del EJC y permitiría el consumo de agua de diferentes cuerpos de agua que puedan encontrar. Los resultados mostraron que el carbón activado fue un material adecuado para la filtración, por el contrario la arena empleada no mejoró la calidad del agua.
Propuesta de un sistema de recolección de agua lluvia en el edificio BACAD1 de la Escuela Militar de Cadetes “General José María Córdova”
Authors: Bernal Lugo Rodrigo Andrés , Cantor Rodríguez Luis Alejandro , Castiblanco Costilla Jhonnatan , Blanco Londoño Sergio Andrés
Published: September 2020

En diferentes instituciones existe una gran demanda de agua en actividades de limpieza y mantenimiento, tales como lavado de pisos y fachadas, y riego de plantas. Sin embargo, estas actividades no requieren del uso de agua potable, por lo que su demanda se puede abastecer con agua lluvia. Por lo tanto, este artículo presenta una propuesta para implementar un sistema de recolección de agua lluvia del edificio BACAD1 de la ESMIC con el objetivo de reducir el consumo de agua potable y, a su vez, contribuir al cuidado del medio ambiente.
Pendeteksi Bola Pada Robot Penjaga Gawang Menggunakan Metode Hough Circle
Authors: Pradana Alwi Widi , Irmawati Dessy
Published: September 2020

Robot penjaga gawang bertugas untuk dapat menghadang bola berwarna oranye memasuki gawang. Robot tersebut harus mampu mendeteksi bola dengan akurat untuk menentukan pergerakan robot selanjutnya. Artikel ini mendeskrepsikan pengembangan robot penjaga gawang yang mampu mendeteksi warna dan bentuk boladengan metode hough circle menggunakan emgucv. Metode pengembangan yang dilakukan merujuk pada modifikasi ADDIE pada pengembangan robot speak bola. Hasil dari pengembangan ini adalah lapangan robot dan robot penjaga gawang. Hasil unjuk kerja menunjukkan pendeteksian bola memiliki presentase rerata sebesar 80%, sedangkan kemampuan menghadang bola sebesar 90%. Penerapan metode hough circle terdiri atas beberapa proses yaitu: (1) mencari ciri warna bola, langkah selanjutnya dengan menggunakan ROI dan objek selain ROI ditutupi dengan warna hitam; (2) objek yang sudah di ROI lalu dideteksi melalui konversi warna ke bentuk HSV dengan memberikan jarak deteksi warna pada channel Hue untuk mendeteksi warna Kembali; (3) filter gambar menggunakan dillate untuk membersihkan noise pada gambar; (4) mendeteksi tepi bola menggunakan canny detection untuk melihat contour berbentuk lingkaran; dan (5) menggunakan Hough Circle untuk mendeksi warna orange dengan bentuk bola. Metode hough circle dalam pendeteksian bola oranye berhasil diterapkan. Untuk pengembangan ke depan, perlu diperhatikan terkait teknis mekanik agar tidak membatasi pergerakan robot.
Raspberry Pi Sebagai Pendeteksi Patahan pada Rel Kereta Api
Authors: Setiawan Muhammad Adi Febri , Fajaryati Nuryake , Purpratama Ario Chandra , Santoso Rohmat
Published: September 2020

Kereta api adalah salah satu transportasi umum yang banyak digunakan masyarakat. Untuk itu seluruh kereta api memerlukan perawatan setiap saat agar kenyamanan penumpang dapat dijamin. Tidak terkecuali rel sebagai jalur kereta sentiasa harus rawat oleh pengelola. Kerusakan rel kereta api dapat berupa patahan pada rel, sambungan rel yang terlalu jauh, dan halangan yang berada di sekitar rel kereta. Kerusakan tersebut dapat dideteksi menggunakan sensor ultrasonic yang dihubungkan  dengan Raspberry Pi sebagai mini PC. Ketika sensor ultrasonic mendeteksi kerusakan, maka Raspberry Pi akan mengunggah data kerusakan beserta koordinat lokasi kerusakan yang didapat dari GPS yang terpasang ke database Firebase. Daftar kerusakan rel kereta api ditampilkan dalam bentuk web.
Pengembangan Modul Praktik Sistem Audio dengan Pendekatan Proyek
Authors: Pangat Muhammad Nur , Waluyanti Sri
Published: September 2020

Pembelajaran berpusat pada siswa menuntut keaktifan peserta didik. Keaktifan belajar peserta didik dapat didukung melalui pengembangan media pembelajaran. Pendekatan pada model pembelajaran proyek dinilai tepat untuk mengembangkan keaktifan belajar peserta didik. Jobsheet praktikum mata kuliah sistem Audio belum mendukung keaktifan belajar peserta didik. Mata kuliah tersebut memerlukan modul praktik yang memicu keaktifan peserta didik agar memiliki pemahaman materi dan tertib melakukan kegiatan praktik. Artikel ini bertujuan untuk mendeskripsikan tingkat kelayakan modul praktik Sistem Audio yang mendukung keaktifan belajar. Tahapan pengembangan media pembelajaran meliputi: (1) identifikasi potensi dan masalah; (2) pengumpulan informasi; (3) desain produk; (4) penyusunan modul; (5) validasi desain; (6) perbaikan desain; (7) uji coba pemakaian; (8) revisi produk; dan (9) penyebaran produk. Hasil penelitian menunjukkan bahwa modul praktik sistem audio yang sudah direalisasikan mendapatkan validasi oleh ahli materi sebesar 88,4 %, oleh ahli media sebesar 80,7%; dan uji pemakaian oleh peserta didik sebesar 81,25%. Ketiga penilaian tersebut menunjukkan bahwa media pada kategori sangat layak digunakan. Dari ketiga perolehan tersebut, modul praktik sistem audio sangat layak digunakan sebagai bahan ajar peserta didik. Modul Pembelajaran berbasis proyek dinilai mampu mendukung aspek kemandirian dan sejalan dengan penerapan pembelajaran andragogi. Hasil ini dapat ditindaklanjuti untuk mengetahui penerapan modul pembelajaran berbasis proyek di kelas untuk meningkatkan kemandirian dan keterlibatan peserta didik.
Deprescribing in psychiatry: challenges and opportunities
Authors: Bibekova Zh. B. , Zarovnyy Kirill Vladimirovich , Tsyganova V. O.
Published: September 2020

Many recommendations, protocols describe the indications for starting medication, but only some of them indicate when they should be discontinued. An analysis of publications indicates a deficit of research in this area, especially in psychiatry. As part of this review, we tried to provide information that provides valuable information about this procedure, about the experience of other countries. Based on a literature review, it was found that in some countries there is already consensus on how to identify a patient who may be reevaluated, recommendations and algorithms have been developed for this procedure with minimal risk to the patient.
antisocialidad empresarial
Authors: Guardado Lopez Sinuhe Carlos
Published: September 2020

Las organizaciones en la actualidad enfrentan múltiples retos que inciden en la forma y el alcance de sus objetivos. Uno de estos retos es la correcta gestión del talento humano en un vertiginoso y turbulento ambiente. Por lo general, se considera que el área o departamento de Recursos Humanos efectúa de forma adecuada las diversas tareas que le han sido encomendadas, entre estas destacan el reclutamiento y selección del personal, tales actividades son fundamentales para el funcionamiento de la empresa. Sin embargo, algunos empleados actúan en contra de los intereses de la organización y su colectividad, lo cual debería de inquietar a los gerentes y a los encargados de Recursos Humanos de las empresas. Los costos de las conductas antisociales al interior de la organización y que la Ciencia de la Administración ha matizado con el nombre de “anómalas” o “desviadas”, cuestan millones de dólares al mundo empresarial. El presente manuscrito interdisciplinario (Neuropsicología, Criminología y Ciencia de la Administración), fundamenta científicamente las conductas antisociales, sus causas y los factores de riesgo endógeno y exógeno, que enmarcan las conductas citadas.
“Germany and World”: Dmitry Merezhkovsky interviewed by the French journalist Marylie Markovitch
Authors: Stroev Alexander
Published: September 2020

The article is dedicated to the interview which Marylie Markovitch (1866 – 1926, born Amelie Neri), the French journalist and writer of the feminist trend, had with Dmitry Merezhkovsky. The meeting took place in the fall of 1915 during Markovitch’s stay in Russia as a special correspondent for “Le Petit journal” and “Revue des Deux Mondes”, however, unlike other Markovitch’s publications, the interview with Merezhkovsky was published behind time, on January 22, 1916. The author notes that both the writer and the journalist address directly to censorship, with Markovitch managing, however, to convey the position of the Russian liberal intelligentsia to the French reader. According to the author of the article, Markovitch represents Merezhkovsky not only as a famous author, well known in France, but as a prophet, quoting his article “Iron under the Hammer” in the first part of the interview. The original French text of the interview, accompanied with the Russian translation, is fully reproduced in the article. The publisher’s attention is focused on an attempt to reconstruct the subtext of the interview, which is profoundly affected by Markovich and Merezhkovsky’s conscious striving for a theatricalized dialogue.
Valery Bryusov and the musical world of Russia
in the late 19th — early 20th centuries (Introduction)
Authors: Gevorkian Armen
Published: September 2020

While there are many studies on biography, literary work, and the
epistolary heritage of V.Ya. Bryusov, his connections with the musical world of Russia
in the late 19th — early 20th centuries remain on the periphery of research interest.
Significantly less attention was paid to the historical and literary study of the poet’s
personal and creative contacts with composers, music critics, and musicologists. In
the late 19th — early 20th centuries V.Ya. Bryusov’s poetry as a source of musical
compositions attracted composers of various creative and aesthetic principles, from
realistic to modernist, each of whom found in Bryusov's works related images,
themes and motifs. Today, the names of more than thirty composers, who addressed
both original works and translations of the head of Russian Symbolism, are known.
Among them are composers who by the beginning of the 20th century had become
original figures of Russian musical culture — A.T. Grechaninov, S.V. Rachmaninov,
N.K. Metner, R.M. Glier, S.I. Vasilenko — and less known today V.I. Rebikov,
A. Kankarovich, A.G. Shaposhnikov et al. One of the first works devoted to this topic
was an article by the poet’s sister, Nadezhda Bryusova, “Music in Valery Bryusov’s
works” (Iskusstvo, 1929, no. 3 – 4), outlining two main areas of research: historical
and literary and theoretical, philosophical and historical. O. Tompakova, V. Dronov,
E. Etkind et al. also researched Bryusov’s connections with the musical culture of
Russia at the beginning of the 20th century. Interest in Bryusov’s work did not fade
even after the poet’s death, many Soviet composers turned to his poetry in the new
socio-political environment. The Appendix contains materials for the annotated
bibliography of music editions related to Bryusov
“Pushkin Dictionary” by G.A. Shengeli:
The unpublished article by the author
of the concordance of A.S. Pushkin’s poems
Authors: Vasilyev Nikolay , Zhatkin Dmitry
Published: September 2020

The publication introduces into scientific circulation an article by
G.A. Shengeli (1894 – 1956), dedicated to “Pushkin's Dictionary” prepared by him in
the second half of the 1930s, which was conceived as a concordance of the classic’s
poetry, but remained unpublished (the manuscript was most likely lost). Dated 1955
by the authors and written by Shengeli to notify writers and scholars about the goals,
structure and informational possibilities of the “Pushkin Dictionary”, the article is
still relevant, being one of the few concrete testimonies of the scientist’s intention
to study Pushkin’s language and linguistic poetics. The text is published according
to the typescript with the author’s corrections, preserved in the fund of the journal
"Oktiabr’" in the Russian State Archives of Literature and Arts. In Shengeli’s article
it is noted that the very idea of compiling a dictionary to the works by Pushkin as the
creator of the Russian literary language arose long ago, but the lack of scientifically
reliable Pushkin editions hindered the implementation of the plan. The compilers of
the Pushkin Dictionary took as a basis the texts of the 1936 six-volume Collected
Works, issued by the Goslitizdat, where, according to the scientist, this problem was
generally overcome. Highlighting the explanatory dictionary and the concordance
dictionary as two main types of works describing the linguistic features of one or
another author, Shengeli argues the choice of concordance, presented in the form of
a set of dictionaries, united by a common word index, for composing the corpus of
Pushkin's poetic language.
Unknown play by Vladimir Bogoraz-Tan
Authors: Soshkin Evgeny
Published: September 2020

Vladimir Germanovich Bogoraz (1865–1936, pseudonyms: Tan,
Tan-Bogoraz, Bogoraz-Tan), the famous ethnographer, linguist, religious scholar,
and researcher of Northern peoples, was also a prolific and popular fiction author, in
particular, a prominent representative of the so-called prehistoric fiction, i.e. fiction
about prehistoric times. This is the first publication of Bogoraz’s play “Dragon
Victims” which is a revision of his prehistoric novel under the same name (1909,
“Sons of Mammoth” in English translation of 1929), commissioned in 1920 by the
Section of Historical Pictures at the Petrograd Theater Department of the People's
Commissariat of Education, after Bogoraz, at that time an employee of the Petrograd
Museum of Anthropology and Ethnography, had been invited by the Section to write
an introduction for the upcoming paleophantastic play “Rhino Hunt” by N.S. Gumilev.
The text of Bogoraz’s play “Dragon Victims”, preserved in the archive (St. Petersburg
Department of the Russian Academy of Sciences Archives), is published according
to the typescript with author’s handwritten corrections. In a detailed introductory
article, the publisher clarifies the dating, the history of creating, and the literary
characteristics of the play as compared to the novel, as well as the programmatic
nature of the encouraging attitude to composing plays on prehistoric themes that came
from A.M. Gorky, the founder and head of the Section.
Uma revisão da noção de interdisciplinaridade: possíveis contribuições para a sala de aula de línguas estrangeiras na escola brasileira
Authors: Retamar Hugo Jesús Correa
Published: September 2020

A interdisciplinaridade, aliada à formação cidadã, é orientação para o ensino de língua estrangeira na escola. Contudo, é um conceito polissêmico e ainda pouco compreendido por professores e seus formadores. Logo, buscando promover a discussão sobre interdisciplinaridade em Linguística Aplicada (LA) e assim contribuir para atitudes interdisciplinares nas aulas de Língua Estrangeira (LE), neste artigo: 1) situo historicamente a interdisciplinaridade; 2) busco um entendimento dessa noção; 3) aproximo interdisciplinaridade e a LA voltada ao ensino de línguas; 4) reviso pesquisas nacionais em LA, com dados naturalísticos, que unem interdisciplinaridade e ensino de LE na escola.
Oficina PLURES: valorizando o plurilinguismo nos anos iniciais.
Authors: Kuchenbecker Ingrid , Santos Roberta Passos dos
Published: September 2020

O presente trabalho tem como objetivo refletir sobre novas práticas no ensino e aprendizagem de línguas voltadas para a sensibilização linguística nos Anos Iniciais, através do relato de uma oficina realizada pelo projeto de extensão PLURES. A oficina baseada em uma abordagem plural foi ministrada no terceiro ano do ensino fundamental do Colégio de Aplicação da UFRGS, que já se caracteriza como um espaço de diversidade linguística e cultural. Observa-se a importância de integrarmos o plurilinguismo nas práticas curriculares de forma coerente e articulada, tendo em vista a formação de estudantes abertos ao conhecimento plurilíngue e a novas culturas.
Perceptional Analysis of Msmes Tax Justice Aspect
Authors: N Susanto Fransiscus X , Pesudo David A A , Warouw Michael Victor
Published: September 2020

This study aims to identify how the role of tax justice for taxpayer of Small and Medium sized enterprises (SMEs) will affect the level of compliance with paying taxes. The results of this study are also useful for Direktorat Jendral Pajak to identify how SMEs react to these policies so that they can represent the condition of their business in their obligation to pay taxes. This study used a qualitative method with a descriptive approach through questionnaires and in-depth interviews with respondents. The population of this study was SMEs assisted by Dinas Koperasi dan UMKM kota Salatiga with 1,656 business units with the method of determining many samples using the slovin formula measurement and with convenience sampling. The impact of the application of PP 23 of 2018 has been felt by taxpayer of SMEs since July 2018, the reduction in tax rates by half a percent of the previous tax rate has been proven to increase tax compliance for taxpayers of SMEs but the application of PP 23 of 2018 does not affect tax compliance for taxpayers of SMEs who have previously obeyed and taxpayer of SMEs with the motive to pay certain taxes.
PERMANENT SYNCHRON MAGNET MOTOR SPEED OBSERVER BASED ON LEAST SQUARES SUPPORT VECTOR MACHINE REGRESSION
Authors: Yuhendri Muldi , Hambali Hambali , Muskhir Mukhlidi
Published: September 2020

Motor speed control requires motor speed data as feedback from control actions. Motor speed data is usually obtained from the speed sensor. In this paper, the motor speed observer for permanent magnet synchronous motor is proposed to obtain motor speed data based on motor back emf voltage making it more economical without a speed sensor. The Speed observer is designed based on the Model Reference Adapative System (MRAS) with using Least Squares Support Vector Machine Regression (LSSVMR) algorithm for adaptation mechanism tools. The proposed speed observer is tested with varying motor speeds. The test results show that the MRAS-based motor speed observer using LSSVMR has successfully estimated the rotation speed of the permanent magnet synchronous motor based on the back emf motor voltage. It can be seen from the maximum error of  the motor speed, ie only 3.7 rpm at transient conditions and close to zero at steady state
ENDOPARÁSITOS DE PHILODRYAS OLFERSII (LICHTENSTEIN, 1823) EN AMBIENTES DE RESTINGA DEL DELTA DEL RÍO PARNAIBA, NORDESTE DE BRASIL
Authors: De Castro Araújo Kássio , De Sousa Silva Charles , De Sousa Machado Heitor Tavares , De Oliveira Cícero Ricardo , Waldemar Ávila Robson
Published: September 2020

Lista de endoparásitos son fundamentalmente importantes porqué contribuyen para la comprensión de la biodiversidad. Las infecciones endoparásitas pueden estar asociadas a la historia evolutiva del huésped del parásito o variar según la dieta y el hábitat; así, es importante investigar tales infecciones en distintos ambientes, a la vez que las condiciones ambientales y disponibilidad de recursos pueden influir en la composición y estructura de los helmintos en ensambles de serpientes. Aquí, investigamos los endoparásitos asociados con Philodryas olfersii (Lichtenstein, 1823), y presentamos la revisión bibliográfica de los endoparásitos asociados con el género Philodryas. Buscamos los endoparásitos relaccionados con la serpiente P. olfersii en el Delta del Parnaíba, región costera del estado de Piauí, noreste de Brasil. Hemos analizado la presencia de ectoparásitos en la epidermis y la cavidad oral, y endoparásitos en los siguientes órganos: tracto digestivo, pulmones, corazón, hígado y riñones, utilizando los descriptores parasitológicos: prevalencia, abundancia, abundancia promedio e intensidad promedio de infección, para describir la comunidad de endoparásitos. Registramos 312 especímenes de endoparásitos pertenecientes a nueve tasas: Kalicephalus costatus Rudolphi, 1819, Strongyloides ophidiae Pereira 1929, Physaloptera sp., Physalopteroides venancioi Lent, Freitas & Proença, 1946, larva de Cosmocercidae, Raillietiella furcocerca (Diesing, 1835), Ophiotaenia sp., cistacantos y un trematodo digenea no identificado. Nematodos y pentastómidos fueron los taxones más abundantes infectando P. olfersii. Nuestros resultados contribuyen a la expansión del conocimiento acerca de los endoparásitos de P. olfersii, con destaque para la naturaleza pionera del presente estudio, el primero en investigar el parasitismo en reptiles del Delta del Parnaíba; por consiguiente, alentamos más estudios parasitológicos con vista a mejorar la comprensión de la relación parásito-huésped en serpientes brasileñas, sobre todo en ambientes costeros.
Hematological response of Tilapia (Oreochromis niloticus) in Laundry wastewater
Authors: Saparuddin Saparuddin , Yanti Yanti , Salim Salim , Muhammad Harish
Published: September 2020

The high concentration of detergent in the aquatic ecosystem potentially affects the physiological condition of the fish by disrupting the respiration process and changing the concentration of blood components and chemistry. The purpose of this study was to determine the condition of the hematological parameters of tilapia (Oreochromis niloticus) exposed to wastewater from the laundry industry. Each treatment was stocked with five fish per aquarium (50 x 30 x 30 cm). This study used a completely randomized design (CRD) technique with six treatments and three replications: P0 (0%) as a control, P1 (1%), P2 (2%), P3 (3%), P4 (4%) and P5 (5%) with each treatment exposed to a specific concentration of wastewater and residues. The results showed that the hemoglobin levels of treatments were decreasing, with the lowest mean of hemoglobin level found in the P2 (7.05 gr%), and the lowest concentration on the 30th day was 7.71 gr%. There were no significant effects of wastewater to the number of erythrocytes and leucocytes among treatments (P>0.05). While there were increasing levels of hematocrit, the largest mean level was found in the P4 treatment with a value of 24.11%, and the largest mean on the 20th day of observation showed a value of 23.51%. Wastewater from the laundry industry can affect the hematological condition of tilapia by decreasing the hemoglobin concentration and increasing the hematocrit levels above the normal condition.
Diversity of Aquatic and Terrestrial Molluscs from Simeulue Island, with Notes on Their Distribution and Some New Records
Authors: Mujiono Nova , Marwoto Ristiyanti M , Heryanto Heryanto
Published: September 2020

Faunistic study on the malacofauna of Simeulue Island was carried out in 2017 after 104 years from the last collection in 1913. 3 locations with 13 stations were observed. 20 families and 50 species of aquatic and terrestrial molluscs were identified. The occurrences of 4 local endemic species were still found and 19 new distributional records were added to the previous list. However, 5 previously listed species were not found in the present study. Through the present study, the accumulative number of malacofauna from Simeulue Island will be around 54 species. 19 species were reported for the first time, including 3 introduced species and 1 new records for Indonesia. 4 local endemic species were still found there after 104 years gone by.