bluuebunny/crossref_metadata_2025 huggingface dataset:
GOVERNANÇA CORPORATIVA EM ENTIDADES DO TERCEIRO SETOR: ANÁLISE DE APAES CATARINENSES
Authors: Schulz Vanessa Juliana , Silva Marcia Zanievicz da , Silva Júlio César da
Published: March 2018

O objetivo da pesquisa consistiu em investigar as práticas de Governança Corporativa evidenciadas por entidades do terceiro setor inscritas no Cadastro Nacional de Entidades Sociais do Ministério da Justiça (CNEN/MJ). Tendo como propósito de responder a seguinte questão problema: quais práticas de Governança Corporativa são evidenciadas por entidades do terceiro setor cadastradas no Cadastro Nacional de Entidades Sociais (CNES/MJ). A pesquisa se caracteriza como exploratória aplicada a uma amostra de dez Associações de Pais e Amigos Excepcionais (APAEs) sediadas em municípios do estado de Santa Catarina. Para a coleta dos dados utilizou-se um roteiro, adaptado do estudo de Rezende, Facure e Dalmárcio (2009), dividido em cinco dimensões: Evidenciação; Estrutura e Funcionamento do Conselho de Administração; Ética e Conflitos de Interesse; Direitos e Propriedade; Requisitos Legais. Com os resultados obtidos verifica-se que há uma necessidade de melhorar os mecanismos de Governança Corporativa nas APAEs dos municípios destacados, mecanismos estes considerados relevantes por transmitirem transparência nas informações e, por se tratarem de entidades que recebem recursos públicos e privados, necessitam primar pela prestação de contas à sociedade
ANÁLISE EMPÍRICA DO NEOCORPORATIVISMO NA AGRICULTURA CANAVIEIRA PARANAENSE
Authors: Rissardi Júnior Darcy Jacob , Shikida Pery Francisco Assis , Lages André Maia Gomes
Published: March 2018

Este trabalho objetivou investigar as novas formas de organização da agroindústria canavieira no Paraná (considerado um representante típico do setor, não sendo nem outlier nem inexpressivo) à guisa do neocorporativismo. Para contemplar este escopo foram coletados dados primários junto às usinas/destilarias, mediante aplicação de questionários. Sob a perspectiva neocorporativista comprovaram-se o papel estratégico das organizações empresarias em torno da consecução de políticas públicas de interesses setoriais e a importância da Câmara Setorial da Cadeia Produtiva do Açúcar e do Álcool, sob jurisdição do Ministério da Agricultura, Pecuária e Abastecimento (MAPA), na defesa dos interesses particulares dos agentes privados.
ONDE ESTÃO OS EGRESSOS DO CAD-UFSC?
Authors: Rocha Rudimar Antunes da , Semprebon Elder , Petroll Martin De La Martinière , Silva Israel Machado da
Published: March 2018

O estudo de caso retrata a atuação profissional de egressos, modalidade presencial, do Curso de Administração (2011-2014), da Universidade Federal de Santa Catarina (CAD-UFSC). Da população de 548 bacharéis deste Survey, obteve-se a amostra de 146 investigados, num Intervalo de Confiança de 95% e Erro Amostral de 7% (RENDER, STAIR JR.; HANNA, 2010). O questionário foi estruturado com perguntas fechadas Estilo Likert (HAIR JR., ANDERSON; TATHAM; BLACK, 2005), fixado no Google Docs e enviado convite por e-mail aos egressos do período em questão. A coleta de dados foi do mês de maio a junho de 2015. O tratamento foi quantitativo com auxílio do SPSS®. A pesquisa apontou que predominam os egressos na faixa etária de 26 a 30 anos (50,7%), sendo 50,7% do sexo feminino, a maioria natural do Estado de Santa Catarina, cursaram o ensino médio em escola privada e que cerca de 30% fez intercâmbio no exterior durante a graduação. Eles trabalham em empresas de médio porte e a faixa salarial oscila de 3 a 6 salários mínimos. A maioria fez ou cursa pós-graduação. Eles realçaram a relevância de graduarem-se na UFSC pelo reconhecimento pessoal e profissional, reforçando as avaliações do CAD-UFSC em 5 Estrela pelo MEC.
DESCENTRALIZAÇÃO DE RECURSOS FINANCEIROS PÚBLICOS FEDERAIS DESTINADOS AO TURISMO PARA MUNICÍPIOS INTEGRANTES DA ROTA MISSÕES – RS: UMA ANÁLISE SOBRE DESENVOLVIMENTO E TURISMO
Authors: Scherer Luciana , Schroeder Ronnie Reus , Botelho Louise De Lira Roedel , Fernandes Sandra Beatriz Vicenci
Published: March 2018

Este é um trabalho sobre turismo, descentralização da administração pública e desenvolvimento. Sobre turismo, traz o argumento acerca da importância desse fenômeno, sendo o repasse de recursos aos municípios, por meio da descentralização de recursos, uma estratégia que propicia o desenvolvimento local e regional. A presente análise é um esforço epistemológico, de natureza descritiva com técnicas quantitativas, no sentido de busca da realidade por meio de dados disponíveis. O estudo debruça-se sobre os municípios integrantes da Rota Missões, no Rio Grande do Sul, no sentido de analisar o cenário da transferência de recursos da União para esses municípios. Por meio de consulta ao Portal da Transparência, foi realizado um levantamento de todos os recursos recebidos no período entre 2003 a 2016, análise essa que propicia um significativo conhecimento sobre a realidade atual em relação à captação de recursos turísticos do Governo Federal desde a criação dessa rota turística. A partir disso, evidenciou-se que a Rota Missões foi contemplada, no período de 14 anos, com R$ 14.088.128,93. Outra constatação importante é que muito dos projetos para os quais se destinou tais valores, houve pouca relação com ações que propiciem a real qualificação e promoção do turismo.  
LOGÍSTICA REVERSA DE RESÍDUOS DE EQUIPAMENTOS ELETROELETRÔNICOS E SEUS REFLEXOS AO MEIO AMBIENTE
Authors: Ocimar Schuinsekel Éder , Catiano Feijó Moura Révis , Rosa Neto Emitério Da
Published: March 2018

A responsabilidade compartilhada pelo ciclo de vida dos produtos é conjunto de atribuições individualizadas e encadeadas dos fabricantes, importadores, distribuidores, comerciantes, consumidores e dos titulares dos serviços públicos de limpeza urbana e manejo dos resíduos sólidos, para minimizar o volume de resíduos sólidos, reduzindo impactos causados à saúde humana e qualidade ambiental decorrentes do ciclo de vida dos produtos. Em vista do crescente consumo que vem ocorrendo, consequentemente o volume de matéria-prima e a preocupação com o meio ambiente exigem das organizações uma reestruturação em seus sistemas logísticos, bem como estabelecimento de diretrizes e estratégias visando à preservação ambiental. Pretende-se demonstrar como é um aspecto relevante e positivo a logística reversa, bem como inclusão de medidas conservacionistas pelas empresas e suas relações com os negócios, suas ações para que realmente a logística reversa complete todo seu ciclo. É foco do artigo, a importância da logística reversa para as organizações e suas relações sobre os aspectos econômico, social e ambiental. A metodologia utilizada é quali-quantitativa, com base em uma revisão bibliográfica em livros e artigos científicos que tratam sobre o tema. Os dados pesquisados são de fontes que tratam sobre logística que levantam dados primários sobre o tema abordado.
ANÁLISE DO MOVIMENTO PERIÓDICO: UMA PROPOSTA DE ABORDAGEM VIRTUAL
Authors: Da Silva Victor Abath , Cruz Frederico
Published: March 2018

Os movimentos com características periódicas estão presentes em muitas situações do dia a dia e em muitos fenômenos da natureza, no entanto a abordagem sobre o tema está sempre ligada a exemplos pouco esclarecedores aos alunos. Apesar de existirem boas propostas de atividades experimentais, para a demonstração dos conceitos básicos nem sempre é possível a sua realização, seja pela falta de local apropriado ou mesmo tempo para sua execução. Pensando nisso, propomos nesse trabalho uma abordagem dos conceitos de movimento periódico com a utilização de recursos computacionais simples. Dessa forma foi possível demonstrar as características de oscilação de uma partícula em movimento circular e de sua respectiva sombra, em torno de um ponto central, tornando assim simples o entendimento sobre esse tipo de fenômeno físico.
TECNOLOGIAS EDUCACIONAIS NO ENSINO DE FÍSICA: RETRATO DAS PESQUISAS NACIONAIS
Authors: Rosa Cleci Teresinha Werner da , Trentin Marco Antonio Sandini , Biazus Marivane De Oliveira
Published: March 2018

A presença das tecnologias no contexto educacional é mais do que uma alternativa didática, representando um recurso imprescindível para a aprendizagem, sobretudo em áreas diretamente vinculadas à tecnologia, como é o caso da Física. Tal identificação confere ao estudo o objetivo de proceder a um levantamento na produção nacional referente à utilização de tecnologia no ensino de Física. O foco central está em fornecer um retrato dessa produção e identificar características e potencialidades do uso dessas ferramentas na voz dos pesquisadores em Ensino de Física. Como recorte, são estabelecidos os periódicos nacionais com classificação Qualis Capes A1, A2 e B1 (Base 2013), na área de Ensino, e o período de 2005 a 2014. Como resultado, o estudo aponta a existência de cinquenta e sete artigos em doze periódicos, que foram categorizados de acordo com o uso ou o dispositivo tecnológico empregado. De forma mais relevante, identificou-se que: na atualidade, as diferentes áreas da Física vêm sendo contempladas nas pesquisas, respondendo a preocupação apontada por Araujo e Veit (2004); dois periódicos nacionais detêm parte significativa da produção nacional na temática; houve um avanço em termos da produção destinadas ao ensino médio em comparação ao mencionado por Martins e Garcia (2011); e a robótica educacional ainda é pouco explorada pelos pesquisadores da área de Ensino de Física.
Benveniste’s Experiments Explained by a Non-Conventional Experimenter Effect
Authors: Beauvais Francis
Published: March 2018

Background: Benveniste’s biology experiments suggested the existence of molecular-like effects without molecules (“memory of water”). In this article, it is proposed that these disputed experiments could have been the consequence of a previously unnoticed and non-conventional experimenter effect. Methods: A probabilistic modelling is built in order to describe an elementary laboratory experiment. A biological system is modelled with two possible states (“resting” and “activated”) and exposed to two experimental conditions labelled “control” and “test”, but both biologically inactive. The modelling takes into account not only the biological system, but also the experimenters. In addition, an outsider standpoint is adopted to describe the experimental situation. Results: A classical approach suggests that, after experiment completion, the “control” and “test” labels of biologically-inactive conditions should be both associated with “resting” state (i.e. no significant relationship between labels and system states). However, if the fluctuations of the biological system are also considered, a quantum-like relationship emerges and connects labels and system states (analogous to a biological “effect” without molecules). Conclusions: No hypotheses about water properties or other exotic explanations are needed to describe Benveniste’s experiments, including their unusual features. This modelling could be extended to other experimental situations in biology, medicine and psychology.
Using GIS and Artificial Neural Network for Deforestation Prediction
Authors: Ahmadi Vahid
Published: March 2018

Geospatial Information Systems (GIS) can provide a great environment for using machine learning algorithm for spatial data such as satellite images. Integrating this functionality with artificial intelligence algorithms for analyzing spatial data enables us to predict challenging disasters such as deforestation. Deforestation as an environmental problems has been recorded the most serious threat to environmental diversity and one of the main components of land-use change. In this paper, we investigate spatial distribution of deforestation using artificial neural networks and satellite imagery. We modeled deforestation process using various factors in determining the relationship between deforestation and environmental and socioeconomic factors. Hence, for this purpose, the proximity to roads and habitats, fragmentation of the forest, height from sea level, slope, and soil type are considered in the model. In this research, we modeled land cover changes (forests) to predict deforestation using an artificial neural network due to its significant potential for the development of nonlinear complex models. The procedure involves image registration and error correction, image classification, preparing deforestation maps, determining layers, and designing a multi-layer neural network to predict deforestation. The satellite images for this study are of a region in Hong Kong which are captured from 2012 to 2016. The results of the study demonstrate that neural networks approach for predicting deforestation can be utilized and its outcomes show the areas that destroyed during the research period.
Dampak Kontrak Psikologis dan Motivasi Kerja Guru
Authors: Abdilah Kurniawan Luluh
Published: March 2018

This article aims to obtain information about the influence of psychological contract and organizational commitment to teacher work motivation in private SMK Kecamatan Pondok Gede, Bekasi. This research uses survey method with path analysis. The results showed there was a direct positive influence of psychological contract and organizational commitment to work motivation, with correlation coefficient value of 0.390 and coefficient value of 0.281.
Iliopsoas Disorder in Athletes with Groin Pain
Authors: Tsukada Sachiyuki , Niga Sadao , Nihei Tadahiro , Imamura Shoichiro , Saito Masayoshi , Hatanaka Jindo
Published: March 2018

Background:

Although iliopsoas disorder is one of the most frequent causes of groin pain in athletes, little is known about its prevalence and clinical impact.

Methods:

We retrospectively reviewed the cases of 638 consecutive athletes who had groin pain. Each athlete was assessed with magnetic resonance imaging (MRI). First, we identified the prevalence of changes in signal intensity in the iliopsoas. Then we classified the changes in signal intensity in the iliopsoas, as visualized on short tau inversion recovery MRI, into 2 types: the muscle-strain type (characterized by a massive high-signal area in the muscle belly, with a clear border) and the peritendinitis type (characterized by a long and thin high-signal area extending proximally along the iliopsoas tendon from the lesser trochanter, without a clear border). Finally, we compared the time to return to play for the athletes who had these signal intensity changes.

Results:

Changes in signal intensity in the iliopsoas were detected in 134 (21.0%) of the 638 athletes. According to our MRI classification, 66 athletes had peritendinitis changes and 68 had muscle-strain changes. The time from the onset of groin pain to return to play was significantly shorter for the patients with muscle-strain changes on MRI than for those with peritendinitis changes (8.6 ± 8.3 versus 20.1 ± 13.9 weeks, respectively; p < 0.0001).

Conclusions:

Changes in MRI signal intensity in the iliopsoas were observed in 21.0% of 638 athletes who had groin pain. Distinguishing between muscle-strain changes and peritendinitis changes could help to determine the time to return to play.
Mexico’s Second Deepwater Auction Successful
Authors: Zborowski Matt
Published: March 2018

Mexico’s second deepwater bid round failed to disappoint as 19 of 29 blocks were awarded, including nine to Anglo-Dutch supermajor and Mexican offshore newcomer Shell. Eleven international firms from 10 countries bidding individually and in consortia won blocks—thought to be mostly oil-rich—in the Perdido Fold Belt, Cordilleras Mexicanas basin, and Salina basin of the Gulf of Mexico.

Nineteen firms from 15 countries placed 39 bids overall. The winning bids comprised 44,178 sq km, 23 well commitments, and $525 million in tiebreak payments. Mexico’s National Hydrocarbons Commission (CNH) announced the results 31 January in Mexico City.

Benjamin Torres-Barron, partner at multinational law firm Baker & McKenzie, which represented four of the companies that participated in the round, said the auction was “very successful” with results “better than everybody expected.” Estimates prior to the event, including those of the government, had approximately 7–10 blocks being awarded.

Instead, about two-thirds of all available blocks were awarded, making Round 2.4 “a great success for the Mexican government,” said Eduardo Corzo Ramos, counsel with international corporate law firm Haynes & Boone. “Very important companies participated and in the bid values you can see how interested these companies are in Mexico’s energy sector.”

Ramos said he was impressed by the strength of the bids and high-dollar tie-breakers placed by the participating firms. “If you look at the winners, everyone was hitting the maximum [royalty of 20%] with a maximum investment factor.” Competition was particularly fierce for Salina basin Blocks 29 and 21, respectively won by Shell and a consortium led by Repsol with tiebreak bonuses of $110 million and $151 million.

Shell’s haul comprised four blocks won on its own, four in a consortium with Qatar Petroleum, and one more in a consortium with Pemex. Five were in the Perdido Fold Belt just south of the Mexico-US maritime border, and four were in the Salina basin to the southeast in the Bay of Campeche.

“We saw a vast, overwhelming victory by Shell,” said Torres-Barron. “I think Shell was very aggressive based on its prior experience” in Mexico’s first deepwater auction, Round 1.4 held in December 2016, in which the firm’s participation comprised a single failed bid alongside Atlantic Rim Mexico for Block 5 in the Salina basin. Shell learned that “you cannot have all the eggs in one basket,” and therefore diversified its bids through a number of blocks this time around, he said.

Shell concurrently announced on 31 January that it made “one of its largest US Gulf of Mexico exploration finds in the past decade” near Perdido in perhaps a signal that a comeback is under way for offshore exploration and development. Chevron and Total, two other majors who have actively participated in Mexico’s deepwater rounds, also reported a US gulf discovery on 31 January.
Statoil, ABB Among Companies Pushing Integrated Operations Initiatives
Authors: Whitfield Stephen
Published: March 2018

Exploration and production companies have long seen integrated operations (IO) as a key innovative strategy for maintaining high production levels. Automation, optimization of processes, and overall data management are the keywords for operators, information technology (IT) companies, and service companies looking to guarantee the maximum exploitation of their available resources. Some of these companies have taken steps recently to make IO system architecture and facilities a more central aspect of their operations.

Integrated Operations Center In 2018, Statoil will establish a new onshore integrated operations center (IOC) that it says will help increase safety, add value, and reduce emissions from its installations on the Norwegian continental shelf (NCS). The company called the IOC an “important step” in its digital roadmap that will enable increased production efficiency and production potential on the NCS.

The IOC is also intended to make data available in a more user-friendly format, providing the operations organization offshore with a better decision-making basis and support. Kjetil Hove, Statoil’s senior vice president for operations technology on the NCS, said that the åsgard field in the Norwegian Sea and Grane and Gina Krog in the North Sea will be the first fields getting support from the center after its establishment, and that new fields and installations will be gradually integrated to allow time for learning and adjustment to new work processes.

The center will help ensure that production on the fields is optimally efficient at all times, solving bottlenecks through condition monitoring. This will be achieved by means of specialist support within production optimization and preventative maintenance from interdisciplinary teams; for example, within production technology, processing, mechanical, and electrical engineering.

“We are now developing tools that will stream data live from the sensors offshore. The tools will help conduct detailed analyses of the production and the performance of equipment on the installations. One important goal for the center is to identify and prevent operational disruptions,” Hove said in a statement.

Statoil said the IOC’s exact location will be determined later this year. The company will integrate the company’s existing production support centers and condition monitoring centers, which are located in various parts of Norway.

On 9 November, Statoil opened the Valemon control room at Sandsli in Bergen. Valemon is the first platform in Statoil’s portfolio to be remote-controlled from land, and while the company currently has no other platforms of this kind it said this solution may be considered for other small- and medium-sized platforms in the future, and remote control may be a central building block of its future operations.
Modeling Barley Yield in a Dark Brown Chernozem after Discontinuation of Long‐term Manure Application
Authors: Agomoh Ikechukwu , Zvomuya Francis , Hao Xiying , Benke Monica
Published: March 2018

Core Ideas

Soil properties at the discontinuation of manuring adequately explained subsequent grain yield.

Soil TOC, TP, TN, and NO3–N were most influential and consistent in explaining yield variability.

No evidence of convergence in grain yield among the discontinued manure treatments after 7 yr.

Fertilizer application on soils that have received long‐term manure application is often not necessary and typically not advised for environmental reasons. Soil properties at the discontinuation of manure application may assist in modeling crop yield trends on such soils in subsequent years. The data used in this study were from a long‐term field experiment initiated in 1973 at the Agriculture and Agri‐Food Canada Research and Development Centre in Lethbridge, Alberta. Soil and plant samples were collected annually from 1973 through 2010 from irrigated plots that were cropped to barley (Hordeum vulgare L.) every year. Soil properties measured at the start of the experiment in 1973 were used to model yield in the control plots while soil properties measured at the end of annual manure applications in 2003 were used as predictors in partial least squares (PLS) regressions to model barley yield in subsequent years in plots in which manure application was discontinued. Soil total N, organic carbon, P, and NO3–N concentrations were the most important soil properties for modeling annual barley grain yield in manured soils using PLS regression. Our results indicate that initial measured soil properties can be a useful tool in modeling yearly crop yield. During the 7 yr following discontinuation of manure application, there was no evidence of convergence in grain yield among amendment treatments, reflecting that the soil nutrient levels were above agronomic thresholds for optimum yields. Long‐term monitoring of yield will assist in the development of models for predicting when nutrient application will become necessary.
Interfaz Colaborativa y Emocional para Interpretar el Sentido Común
Authors: Balcázar-Rengifo Alberto , Cerón Fabio Hernán , Collazos César A. , Gil-Iranzo Rosa
Published: March 2018

El propósito de este trabajo, es diseñar e implementar una aplicación web que relacione sentencias que se asocian con el sentido común, con la connotación emocional que tienen para cada persona. Para definir el marco de trabajo, se propone un conjunto de características que facilitan el trabajo colaborativo y que permitan la interacción de los usuarios fomentando la generación de nuevos conocimientos. Entre ellas: el perfil de usuario, con el que se busca definir elementos que permitan procesar la información obtenida teniendo en cuenta rasgos característicos de los participantes, el chat como herramienta de comunicación ya que permite la interacción en tiempo real, un foro que usa comentarios como medio para recoger el sentido común y emoticones que servirán para representar las emociones que serán asociadas a los comentarios realizados en el foro. Se construyó una aplicación web para recolectar el conocimiento tácito de las personas, conocido como sentido común, en la que los usuarios pueden registrarse y participar realizando sus aportes en foros sobre los diferentes temas propuestos. Para validar la usabilidad de la aplicación se realizó una encuesta a los participantes luego de su participación, de la cual se puede determinar que la inclusión de elementos emocionales y colaborativos como chats, foros y emoticones, facilito la interacción de los participantes, los cuales escribieron y asociaron emociones a sus comentarios. También les fue posible comentar sobre aportes realizados por otros participantes, consiguiendo de esa manera, dinamizar éste proceso evidenciado en la creación de pequeñas discusiones alrededor de un tema.
Economía Computacional Basada en Agentes
Authors: Giraldo-Giraldo Fabián Andrés , Gómez-Perdomo Jonathan
Published: March 2018

El artículo tiene como objetivo mostrar varios trabajos de investigación sobre un enfoque de simulación denominado Economía computacional basada en agentes, el cual rechaza las asunciones de los enfoques de estudio tradicionales que indican que la economía es un sistema cerrado que eventualmente logra un estado de equilibrio, en el que deben realizarse supuestos de racionalidad perfecta e inversiones homogéneas para que los modelos sean tratados analíticamente. En su lugar, ve a la economía como un sistema complejo, adaptativo y dinámico. Este nuevo enfoque permite usar la simulación basada en agentes para comprender que varios agentes económicos (firmas, grupos económicos) con sus propias reglas y objetivos, son capaces de interactuar entre sí y con su entorno para obtener comportamientos emergentes que no son explicables directamente de las propiedades de los agentes individuales.
Editorial Edición # 2
Authors: Vargas Luis Fernando
Published: March 2018

INVESTIGAR Y DIVULGAR EN INGENIERÍAEs necesario hablar de investigación en ingeniería en vez de la investigación y los ingenieros, que puede ser otro tema de reflexión. Es erróneo, como algunos lo han hecho, pensar que ambos conceptos son equivalentes, ya que actualmente, y debido a la evolución misma del conocimiento científico, es común que los equipos de investigación se conformen de forma multidisciplinar, y que a su interior lleguen profesionales de formaciones diversas, sea o no en ingeniería.
Editorial Edición # 4
Authors: Serna-Montoya Edgar
Published: March 2018

LA FUGA DE CEREBROSEl intercambio de cerebros les permite a los países enviar y recibir por igual, y beneficiarse de la experiencia especializada de los profesionales expatriados, y no sólo de sus remesas, tan considerables como puedan ser. El papel de los técnicos hindús expatriados en la construcción, desarrollo y soporte enlas industrias TIC en Bangalore es un excelente ejemplo.
Ciencias Humanas y Emergencia de la Edad Digital
Authors: Fischer Hervé
Published: March 2018

Estamos pasando de la era del fuego a la era digital, o sea, de la era de la energía, que incluye el fuego, el viento, el agua, la electricidad y la energía nuclear, a la era de la información. Pasamos así del binomio energía-materia a un nuevo paradigma epistemológico e instrumental, el de una codificación binaria y de una programación algorítmica con las cuales pretendemos reinterpretar el universo e instrumentarlo con una nueva potencia humana superior a la de las leyes habituales de la naturaleza. El hombre ha escogido marcar con su sello nuestra evolución y hablamos aquí de lo antropoceno. McLuhan fue el último gran pensador de la era del fuego, de los medios de difusión eléctricos; pero no podría ser el nuevo gurú de la era digital. La energía destruye le información. Lo digital la crea y la difunde.
Mitochondria-Targeting Anticancer Metal Complexes
Authors: Erxleben Andrea
Published: March 2018

Background:

Since the serendipitous discovery of the antitumor activity of cisplatin there has been a continuous surge in studies aimed at the development of new cytotoxic metal complexes. While the majority of these complexes have been designed to interact with nuclear DNA, other targets for anticancer metallodrugs attract increasing interest. In cancer cells the mitochondrial metabolism is deregulated. Impaired apoptosis, insensitivity to antigrowth signals and unlimited proliferation have been linked to mitochondrial dysfunction. It is therefore not surprising that mitochondria have emerged as a major target for cancer therapy. Mitochondria-targeting agents are able to bypass resistance mechanisms and to (re-) activate cell-death programs.

Methods:

Web-based literature searching tools such as SciFinder were used to search for reports on cytotoxic metal complexes that are taken up by the mitochondria and interact with mitochondrial DNA or mitochondrial proteins, disrupt the mitochondrial membrane potential, facilitate mitochondrial membrane permeabilization or activate mitochondria-dependent celldeath signaling by unbalancing the cellular redox state. Included in the search were publications investigating strategies to selectively accumulate metallodrugs in the mitochondria.

Results:

This review includes 241 references on antimitochondrial metal complexes, the use of mitochondria-targeting carrier ligands and the formation of lipophilic cationic complexes.

Conclusion:

Recent developments in the design, cytotoxic potency, and mechanistic understanding of antimitochondrial metal complexes, in particular of cyclometalated Au, Ru, Ir and Pt complexes, Ru polypyridine complexes and Au-N-heterocyclic carbene and phosphine complexes are summarized and discussed.
Grid-Based Technologies for In Silico Screening and Drug Design
Authors: Potemkin Vladimir , Grishina Maria
Published: March 2018

Various techniques for rational drug design are presented in the paper. The methods are based
on a substitution of antipharmacophore atoms of the molecules of training dataset by new atoms and/or
group of atoms increasing the atomic bioactivity increments obtained from an SAR study. Furthermore, a
design methodology based on the genetic algorithm DesPot for discrete optimization and generation of
new drug candidate structures is described. Additionally, wide spectra of SAR approaches (3D/4D QSAR
interior and exterior-based methods – BiS, CiS, ConGO, CoMIn, high-quality docking method - ReDock)
using MERA force field and/or AlteQ quantum chemical method for correct prognosis of bioactivity and
the bioactive probability have been described. The design methods are implemented at
www.chemosophia.com web-site for online computational services.
Beta vulgaris – A Mini Review of Traditional Uses in Iran, Phytochemistry and Pharmacology
Authors: Hamedi Shokouhsadat , Honarvar Masoud
Published: March 2018

Background:

Beta vulgaris (family: Chenopodiaceae) is now widely is used more in the food
industry as a rich source of sugar but it is less considered in medicine. Beet has been used in traditional
medicine for hundreds of years to treat a variety of diseases such as constipation, decreased libido, gut and
joint pain and dandruff.

Methods:

This study introduced the benefits of Beta vulgaris by reviewing Iranian traditional
documents from the 10th century until now and also compared modern phytotherapy of plant beet
from the electronic data banks such as ISI, Pub Med and Scopus with findings that extracted from
traditional literature.

Results:

This plant is known in Iranian Traditional Medicine (ITM) as Selgh (Arabic) or Choghondar
(Farsi) and its leaves are used to develop treatments. Results confirmed that the plant referred to as
Selgh in traditional books is that the plant Beta vulgaris in contemporary studies. Treatments that
have not been evaluated in modern phytotherapy but do appear in traditional treatments include fever,
as well as psychological and psychiatric issues. This article tells the history of beet in ITM and can
confirm use of plant Beta vulgaris in medicinal practice. The report can be applied for certification of
plant Beta vulgaris for researchers and experts.

Conclusion:

The findings of this study can help the researchers in producing therapeutic products and
new application.
A Mobile Health App to Reduce Sedentary Time in Inactive Employees: Study Protocol for a Single-Group, Time Series Feasibility Trial (Preprint)
Authors: Kehler Dustin S. , Stammers Andrew N. , Meade Laura , Edye-Mazowita Alex , Hay Jacqueline L. , Semenchuk Brittany , Kanne Vergil , Glasier Kevin , Strachan Shaelyn M. , Duhamel Todd A.
Published: March 2018

UNSTRUCTURED

Extended bouts of sedentary time are common in the modern working environment. As such, effective interventions are needed to counter the adverse health effects of sitting. We developed a theory-informed, mobile health app (i.e. the ENCOURAGE App) designed to interrupt occupational sitting time. The objective of our study is to investigate the effect of the ENCOURAGE App on the number of breaks in sedentary time taken throughout the day. This is a single-group, time series quasi-experiment evaluating the effect of the ENCOURAGE App on breaks in sedentary time. Data will be collected at baseline pre-intervention, 1-week, 1-month and repeated monthly for 6-months thereafter. We will recruit up to 300 individuals that have downloaded the app using an electronic, mobile consent form. The primary outcome of the study will examine a change in the number of breaks in sedentary time from baseline to one-month. We will also recruit a sub-sample of 60 individuals to collect objective data on physical activity and sedentary behaviour. As the modern working environment continues to promote a sedentary lifestyle, there is an urgent need to identify cost-effective solutions that can be scaled for both small and large organizations. This study aims to develop a novel mobile health app to support employees to reduce their sedentary time and become more physically active. The trial has been registered on ClinicalTrials.gov, a registry database of privately and publicly funded clinical research studies (NCT03403270).
Outcome of Critically ill Patients Undergoing Mandatory Insulin Therapy Compared to Usual Care Insulin Therapy: Protocol for a Pilot Randomized Controlled Trial� (Preprint)
Authors: Watkinson Peter J , Barber Vicki S , Young J Duncan
Published: March 2018

BACKGROUND

Observational and interventional studies in patients with both acute medical conditions and long-standing diabetes have shown that improved blood glucose control confers a survival advantage or reduces complication rates. Policies of “tight” glycaemic control were rapidly adopted by many general intensive care units (ICUs) worldwide in the mid 00’s, even though the results of the studies were not generalizable to mixed medical/surgical ICUs with different intravenous feeding policies.

OBJECTIVE

The primary objective of the study is to assess the safety of mandatory insulin infusion in critically ill patients in a general ICU setting.

METHODS

This protocol summarizes the rationale and design of a randomized, controlled, single-center trial investigating the effect of mandatory insulin therapy versus usual care insulin therapy for those patients admitted for a stay of longer than 48 hours. In total, 109 critically ill adults predicted to stay in intensive care for longer than 48 hours consented. The primary outcome is to determine the safety of mandatory insulin therapy in critically ill patients using the number of episodes of hypoglycaemia and hypokalaemia per unit length of stay in intensive care. Secondary outcomes include the duration of mechanical ventilation, duration of ICU and hospital stay, hospital mortality, and measures of renal, hepatic, and haematological dysfunction.

RESULTS

The project was funded in 2005 and enrolment was completed 2007. Data analysis is currently underway and the first results are expected to be submitted for publication in 2018.

CONCLUSIONS

This protocol for a randomized controlled trial investigating the effect of mandatory insulin therapy should provide an answer to a key question for the management of patients in the ICU and ultimately improving outcome.

CLINICALTRIAL

International Standard Randomized Controlled Trial Number ISRCTN00550641; http://www.isrctn.com/ISRCTN00550641 (Archived at WebCite: http://www.webcitation.org/6xk8NXxNv).
Infective Endocarditis In A Patient With Ventricular Septal Defect And Patent Ductus Arteriosus
Authors: PD., et al Sattwika
Published: March 2018

Infective Endocarditis In A Patient With Ventricular Septal Defect And Patent DuctusArteriosus
The Past, Present, and Future of Myocardial Revascularization
Authors: Setianto Budi Yuli
Published: March 2018

One of the important diagnostic modalities in cardiology is cardiac catheterization, which is onetool for myocardial revascularization. This examination is particularly useful in the aspect ofcardiac hemodynamic evaluation, among other utilities. This review describes the advance ofcardiac catheterization from the beginning of its discovery to future development.
NEEM (AZADIRACHTA INDICA A. JUSS) AS A SOURCE FOR GREEN SYNTHESIS OF NANOPARTICLES
Authors: K Girish
Published: March 2018

Nanoscience has found various applications in different biomedical fields. The synthesis of nanoparticles (NPs) has become a vast area of research due to its potential applications. These particles can be prepared by different chemical, physical, and biological approaches. In recent years, green synthesis of NPs using plant extracts has gained much interest due to non-toxicity and very low cost of synthesis. The plant extracts act both as reducing agent as well as capping agent. Neem (Azadirachta indica A. Juss) is a well-known medicinal plant and has been studied for the biosynthesis of NPs. A. indica has various phytochemicals identified that can reduce the metal ions. The bioreduction of NPs from neem extract is an eco-friendly, low cost, and green synthesis method and these NPs are reported to exhibit good antimicrobial, mainly antibacterial, activity
ANTIOXIDANT AND ANTICANCER ACTIVITIES OF HEXANE FRACTION FROM CARICA PAPAYA L. MALE FLOWER
Authors: Sianipar Masria Phetheresia , Suwarso Edy , Rosidah Rosidah
Published: March 2018

Objective: This study examined the antioxidant and anticancer potential activities of the hexane fraction from the male flower of Carica papaya L., which is long been known to be a very important source of nutraceutical and pharmaceutical.Methods: Standard fractioned (fraction) method with phytochemical screening. The antioxidant activity was carried out using the α,α-diphenyl-β- picrylhydrazyl method and the anticancer potential activity was carried out using 3-(4,5-dimethythiazol-. 2-yl)-2,5-diphenyl tetrazolium bromide assay to check the cytotoxic activity on WiDr (colon cancer cell) and Vero cell (normal cell).Result: Phytochemical screening of the hexane fraction from the male flower of papaya shows a strong sign of triterpenoids and steroids; while the IC50 of antioxidant value was 100.81±1.180 μg/ml. Cytotoxic effect shows that the hexane fraction of papaya male flower had selectivity to WiDr cell (colon cancer cell).Conclusion: This study provides evidence that C. papaya L. male flower possesses antioxidant activity, as well as cytotoxic and chemopreventive properties. It might be beneficial as medicinal plant as an antioxidant and anticancer nutraceutical and pharmaceutical sources.
THE FORMULATION OF DRY CURCUMA (CURCUMA XANTHORRHIZA ROXB.) EXTRACT MICROCAPSULES BY SPRAY WET MICROENCAPSULATION TECHNIQUES
Authors: Samran Samran , Dalimunthe Dalimunthe , Dalimunthe Dalimunthe , Dalimunthe Dalimunthe
Published: March 2018

Objective: Curcuma xanthorrhiza Roxb. was used as hereditary medicinal plant for prevention of liver dysfunction, gastrointestinal disease, fever, and hemorrhoid. Curcuma extract was easy to damage because the light exposure, change of pH, weather and a long period of storage time. The problem can be solved by coating the extract with spray wet microencapsulation (SWM) technique. SWM technique is a method of preparing microcapsules in which a solution, suspension, or emulsion with a charged matrix is sprayed into opposing solution. The aim of this research was to formulate the dry Curcuma extract with SWM technique using sodium alginate as matrix.Methods: Brown algae (Sargassum ilicifolium) was a main resource of alginate acid. It was isolated using HCl 5% to make alginate acid and sodium alginate that was obtained by adding Na2CO3 5% to alginate acid solution. The microencapsulation process of Curcuma extract was done by SWM technique. The formula of Curcuma extract microencapsulation was design into three formulas: F1, F2, and F3. Microcapsules of Curcuma extract were being characterized for color intensity, analysis of scanning electron microscope (SEM), compressibility index, flowing time, and determination of angle repose.Results: The results showed that the higher concentration of sodium alginate used, the dry Curcuma extract microcapsules produced better. Particle size of extract microcapsules of Curcuma extract microcapsules SEM from F1, F2, F3 was 20 μm whereas dry weight of extracted microcapsule of Curcuma grows with increasing concentration of sodium alginate: F1 (0.2%) 19.86±0.11 g, F2 (0.4%) 20.66±0.73, F3 (0.6%) 21.29±0.64. The flowing time of F1, F2, and F3 was 6.92±0.56, 7.42±0.50, and 8.05±0.54 s consecutively.Conclusions: Based on the analysis of the study result, it can be concluded that the raw materials of Curcuma extract can be made by SWM technique using sodium alginate isolated from brown algae, and the characterization of dry Curcuma extract microcapsule of the three formulas met the requirements of the pre-formulation tests for capsule dosage form.
TO EVALUATE THE ANTI-ATHEROSCLEROTIC POTENTIAL OF QUERCETIN IN ALLOXANINDUCED DIABETIC RATS FED WITH HIGH-FAT DIET
Authors: S Biplav , G Sindhura , Gowda K P Shivalinge
Published: March 2018

Objective: The main aim of the present study is concerned with the evaluation of anti-atherosclerotic potential of quercetin in alloxan-induced diabetic rats fed with high-fat diet (HFD).Methods: Atherosclerosis (AS) is the major cause for many of the cardiovascular disease, and it is accelerated in the presence of diabetes mellitus and causes profound alterations in the lipid profile. The method used for the induction of AS was using HFD for 60 days. In this study, rats were divided into four groups (n=6). Group I served as normal control, Group II alloxan (120 mg/kg b.w i.p)-treated diabetic rats, Group III received quercetin (50 mg/ kg b.w p.o), and Group IV received atorvastatin (10 mg/kg b.w p.o) along with alloxan (120 mg/kg b.w i.p) on the 1st day of the days of the study period. AS was induced in Group II, Group III, and Group IV rats by feeding them with HFD from the 1st day to 60th day. The body weight, feed intake was measured daily. The blood was withdrawn from retro-orbital plexus, and the serum was used for the estimation of lipid profile (total cholesterol [TC], triglycerides [TGs], low-density lipoprotein cholesterol [LDL-C], very LDL-C [VLDL-C], and high-density lipoprotein cholesterol [HDL-C]). After scarification under overdose of ketamine, the histopathological study of aorta was carried out.Results: The results showed that the quercetin-treated rats showed a decrease in body weight gain, decreased levels of TC, TGs, LDL-C, and VLDL-C, and increased levels of HDL-C were observed in Group III rats when compared to alloxan-induced diabetic rats fed with HFD (Group III). The histopathological study of aorta showed no development of plaques and of foam cells.Conclusion: From this study, it can be calculated that quercetin has anti-atherosclerotic activity as it significantly altered overall lipid profile in diabetic rats fed with HFD. This activity may be attributed to its antioxidant, inhibition of HMG-CoA reductase activity of quercetin.
ACTIVITY SALIVARY BACTERIA OF ACUTE LYMPHOBLASTIC LEUKEMIA CHILDREN IN CHEMOTHERAPY PHASE
Authors: Muthalib Aliyah Abdul , Budiardjo Sarworini B , Suharsini Margaretha
Published: March 2018

Objective: The objective of this study was to investigate the differences activity of salivary Streptococcus mutans bacteria in children suffer acute lymphoblastic leukemia (ALL) in phase of chemotherapy, induction, intensification/consolidation, and maintenance.Methods: This study was a laboratory observational, and cross-sectional method, conducted 19 ALL children in phase of chemotherapy, induction, intensification/consolidation, and maintenance. 2 mm of dental plaque was collected from mesiobuccal first permanent molar and incubated for 48 h at 37°C, and the bacterial activity of S. mutans measured by Cariostat.Results: Odds ratio analysis among chemotherapy phase of induction, intensification/consolidation, and maintenance is not significant (p>0.05) differences.Conclusion: The highest activity bacteria of S. mutans were found in the induction phase
POTENTIAL OF DUNALIELLA SALINA MICROALGAE TO AMELIORATE HIGH-FAT DIET‑INDUCED OBESITY IN ANIMALS’ RODENT
Authors: El-baz Farouk K , Aly Hanan F
Published: March 2018

Objective: This study was carried out to investigate the potential of Dunaliella salina microalgae to ameliorate obesity induced by high-fat diet (HFD) in male Wistar rats.Methods: Fifty rats weighing 150–160 g were fed HFD for 12 weeks. The rats were randomly divided into five groups of ten rats each. Obese rats were orally administered D. salina ethanolic extract (150 mg/Kg body weight), and orlistat as standard drug (12 mg/Kg body weight), for 6 weeks.Results: Treatment of obese rats with both D. salina and orlistat had a significant effect in reducing body and liver weights as well as visceral fat, inhibiting pancreatic lipase activity, decreased lipid profile, and increased fecal fat and ameliorating liver function enzymes activity, insulin, blood glucose, and leptin levels. Besides, food intake was insignificantly increased as a result of D. salina and orlistat treatments compared with normal control rats.Conclusion: It could be concluded that D. salina rich in β-carotene significantly reduced body weight gain and ameliorated several metabolic pathways implicated in obesity and its related complication. Hence, further intensive study must be carried out to formulate D. Salina extracts to apply as a promising natural anti-obesity nutraceutical drug.