bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of the Empirical Ionospheric Models During Three Severe Geomagnetic Storm Occurred in 2015
Authors: SAĞIR Selçuk , ERBAY Şerife
Published: December 2022

The geomagnetic field acts as both the shield and the electron density regulator for the ionosphere. The effect of the geomagnetic field on the ionosphere can be examined separately for the geomagnetically quiet and disturbed days. In the current study, the performance of the ionospheric models was evaluated for three different severe geomagnetic storms periods during the year of 2015, which was in the beginning of the descending phase of the 24th solar cycle. These three storms occurred during 17-18 March, 22-23 June and 20-21 December of year 2015 in which first one expressed as St. Patrick's Day geomagnetic storm. The relationship between Total Electron Content (TEC) was measured by Global Positioning System (GPS) and evaluated with NeQuick 2, IRI 2016, IRI Plas (without any input- “IRI Plas”) and IRI Plas TEC (with TEC input- “IRI Plas TEC”) global models at three Turkey IGS station namely Ankara (39.57 N, 32.53 E), Istanbul (40.58 N, 29.05 E) and Erzurum (40.39 N, 40.42 E) investigated. The comparison was made separately for pre-storm, during storm and post-storm by using the Mean Absolute Error (MAE), Root Mean Square Error (RMSE) and Mean Absolute Percentage Error (MAPE) metrics and symmetric Kullback-Leibler Distance (KLD) methods. Among the empirical models, IRI Plas TEC is generally present to be better results than other models for all storm processes. It can be stated that IRI 2016 is better in the storm return phase compared to other phases of the storm.
The Acknowledgments in Student Theses: Eastern and Western Ideology
Authors: Putikadyanto Agus Purnomo Ahmad , Rahmawati Fithriyah , Setiadi Asep
Published: December 2022

People's ideologies in various Western and Eastern countries influence language use, including acknowledgment writing. This qualitative study attempts to establish Eastern and Western ideologies in the acknowledgments of the student's final projects using a critical discourse approach. Eastern ideology was examined through 57 acknowledgments of student theses from eastern countries (Indonesia, Malaysia, Saudi Arabia, and Singapore) written in Indonesian and English. In comparison, Western ideology was examined through 53 acknowledgments of student theses from western countries (United States of America, England, and Germany) written in English. The linguistic features of Fairclough and Santoso were used to reveal the Eastern and Western ideology found in the acknowledgments of students’ final projects. The findings revealed that the language used to acknowledge eastern ideology was rigid. In Muslim-majority countries, gratitude to God comes first, and there are expressions of gratitude to parents. Gratitude expressions found in some eastern countries were based on the hierarchy of positions. The Western ideology in the acknowledgment, on the other hand, can be seen in the use of more expressive languages. Moreover, the acknowledgment format is not rigid and is arranged according to the hierarchy of works' contributions. The findings also indicate that identity has an impact on language.
“Family” as a Site of Gender and Class Struggles in Catherine Lim’s The Song of Silver Frond
Authors: Mulyani Sri , Manggala Simon Arsa , Nirwinastu Diksita Galuh
Published: December 2022

“Family” in The Song of Silver Frond (TSOSF) functions as a site of gender and class struggles to challenge the Chinese yin-yang and nei-wai tradition. Continuities and transformations in Chinese familial practices result from complex socio-cultural-generational dynamics. "Family" becomes a battleground of gender and class struggles for the preservation and transformation of those familial traditions. Moreover, the dynamic of ethnicity also intersects with gender and class relations. The traditional Chinese familial practices follow two fundamental Confucian gender foundations: yin-yang and nei-wai. The yin-yang delineation privileges man versus woman. Meanwhile, the private/public distinction of nei-wai relegates the woman's place to the domestic sphere. By employing Post-Structural feminist perspectives focusing on gender intersectionality, this article examines how "family" becomes the site of ethnic-gender-class struggles in TSOSF. The articles revealed that some family members, both men, and women, continue to apply the traditional Confucian rules from generation to generation. However, other members challenge those traditional practices to contest gender and class inequalities to adapt to different sociocultural dynamics in Southeast Asian Society. Thus, this article has articulated the way TSOSF displays "family" as a site of gender and class struggle in Chinese familial practices.
Breve vida de las larvas literarias: las temáticas y el contexto de producción de la revista Larvaria
Authors: Gómez Mutio Ana Rosa
Published: December 2022

El artículo estudia la historia, el contexto y las temáticas de la revista Larvaria (2018-2019), que a lo largo de un año publicó únicamente poemas que no trataran sobre amor. Se publicaron siete convocatorias y seis números que tuvieron gran aceptación entre públicos distintos de los que suelen consultar revistas literarias, como estudiantes de preparatoria y reos de centros penitenciarios. La mayoría de los poemas publicados fueron escritos por jóvenes menores de 30 años. Parte de la clave de su éxito radica en que se creó una página en redes sociales que acompañó la creación, el crecimiento y el cierre de la revista; a la par, a través de imágenes y publicaciones, se cuestionaron diversas definiciones ortodoxas y caducas sobre qué es la poesía y sobre qué significa ser poeta. Larvaria se apoyó en una red de revistas independientes que permitió su distribución, promoción, divulgación y venta a lo largo del territorio mexicano y en el extranjero.
OPTICAL COHERENCE TOMOGRAPHY WITH ANGIOGRAPHY IN THE DIAGNOSIS OF PATHOLOGICAL NEOVASCULARIZATION IN PATIENTS WITH DIABETES ASSOCIATED WITH MYOPIA
Authors: Shchuko Andrey G. , Akulenko Mikhail V. , Samsonov Dmitry Y. , Bukina Vera V.
Published: December 2022

The most dangerous consequences of the global epidemic of diabetes mellitus (DM) are its systemic vascular complications - nephropathy, retinopathy, damage to the main vessels of the heart, brain, peripheral vessels of the lower extremities. These complications are the main cause of disability and mortality of patients with DM. Diagnosis of ophthalmoscopic changes in pathological neovascularization in diabetic patients associated with myopia causes certain difficulties in the work of an ophthalmologist. The use of ophthalmoscopy with a Goldman lens and targeted OCT angiography with an expanded scanning area of 10 * 10 mm allows timely detection of hidden areas of ischemia and neovascularization, as well as to determine the tactics and scope of therapeutic measures in the form of panretinal laser coagulation to stabilize the proliferative process.
COMPARATIVE EVALUATION OF THE ANGULAR DIMENSIONS OF THE MANDIBLE WITH VARYING DEGREES OF PRESERVATION OF THE DENTITION IN MEN AND WOMEN OF THE MATURUSAGE GROUPS (FROM 35 TO 55 YEARS) AND SENILIS(OVER 56 YEARS OLD)
Authors: Mantulina Lilia A. , Zatolokina M. A , Kharchenko V. V , Khvostovoy D. V.
Published: December 2022

Resume. The study of the features of the structure of the lower jaw with preserved and with various degrees of loss of dentition is relevant from the point of view of dental implantology. Materials and methods. A craniometric study of angular dimensions was carried out on 120 3D models of the mandibles of men and women of the age groups Maturus and Senilis, divided into 10 subgroups. The degree of influence of tooth loss on angular dimensions was assessed. Results. In groups with complete acquired adentia, there was a statistically significant decrease in the angles of inclination and protrusion of the chin in men and women from 6° to 14° (p < 0,05), while in other groups with partial adentia, no statistically significant differences were observed. The angle of the lower jaw branch and the basal angle did not respond to tooth loss. Conclusions. The anterior segment of the lower jaw body undergoes maximum restructuring, which is reflected in the reaction of angular dimensions to the complete loss of teeth
STUDY OF MORPHOLOGICAL VARIABILITY OF THE LIVER VISCERAL SURFACE RELIEF
Authors: Chernomortseva Elena S. , Zatolokina Maria A. , Chernomortsev Stanislav E. , Kosheleva Snezhanna S.
Published: December 2022

Resume. Due to the widespread introduction of modern imaging methods in medicine, the study of anatomical variations and congenital anomalies of liver development is of genuine interest to both diagnosticians and clinicians. This article discusses cases of detection of non-standard morphological changes in the human liver revealed during the dissections of organs for the purpose of teaching medical university students. Materials and methods. Using descriptive and comparative research methods, the macromorphological parameters of atypical and additional grooves, fissures, processes and lobes of fixed in 10 % formaldehyde solution liver were studied in detail. Results. Atypical structures of the liver have been identified and described, which complement the overall picture of the morphological variability of the hepatobiliary system, which is undoubtedly relevant in the practice of medical specialists and contributes to improving diagnosis when planning appropriate surgical interventions. Conclusions. A supplemented understanding of the anatomy of the liver, its possible malformations and variants of development, makes it possible to reduce the risk of diagnostic errors, to choose the right tactics for managing patients with hepatic diseases.
MICROBIOLOGICAL AND HISTOLOGICAL PICTURE IN LOCAL CRYO IMPACT ON A SUPPURATING WOUND
Authors: Maskin Sergey S. , Pavlov Alexander V. , Igolkina Lyubov A.
Published: December 2022

Resume. In light of the significant perspectives for the use of elements of physical processing factors in the treatment of purulent diseases of soft tissues, spesial attention should be paid of local cryoinfluence in the debridement of purulent wounds. Purpose of the work: to study changes in the histological and microbiological picture during cryo-treatment of a purulent wound model. Material and methods. Superficial purulent wounds of soft tissues were modeled on 40 male Wistar rats. A dynamic microbiological study of wound smears and histological biopsy specimens was performed with cryotherapy and without interfering with the course of the wound process. Results. The treatment with cryotherapy revealed a statistically significant acceleration of the elimination of the pathogen from the wound, the rapid development of fresh connective tissue and the restoration of the microvascular bed, and the activation of the rate of epithelialization. Conclusions. Debridement and the use of local cryoprocessing contributes to the rapid elimination of the pathogen from the wound, activates the processes of granulation and epithelialization. Further clinical study and introduction into practice of local cryotherapy in purulent diseases of soft tissues is substantiated.
PROFESSIONAL LONGEVITY - WAYS AND MEANS TO ACHIEVEMENT
Authors: Shkarin Vladimir V. , Vorobyov Alexander A. , Adzhienko Vsevolod L. , Andrjushhenko Fedor A.
Published: December 2022

The purpose of this review of the current literature on the problem of longevity was to analyze approaches and actions in the field of public health to ensure professional longevity. The extension of a person's ability to work is carried out by maintaining individual vitality through the receipt of medical services, as well as compensating for the functional ability that decreases with age by using measures and technologies that facilitate working conditions. This prolongation of professional longevity is based on dynamic monitoring of a person's psychosomatic status and the creation of conditions for professional development. Expansion of the scope of periodic medical examinations, corporate programs for maintaining the ability to work, timely medical and rehabilitation measures, innovative personal protective equipment for the musculoskeletal system are most effective within a holistic methodology. The analysis of the literature shows the feasibility of further research aimed at extending professional longevity by substantiating systemic measures at the state level with the full participation of employers and the broad involvement of the employees themselves, as well as the relevance of developing a methodology for extending professional longevity based on maintaining health and performance, covering career guidance, formation and development professional qualities.
FUNGI OBTAINED FROM OLIVE TWIG DIEBACK AND ADULTS OF THE ALIEN PEST XYLOSANDRUS COMPACTUS (EICHHOFF) (COLEOPTERA CURCULIONIDAE SCOLYTINAE)
Authors: VITALE SALVATORE , TOCCAFONDI PAOLO , LUONGO LAURA , BINAZZI FRANCESCO , PETRUCCI MARIANGELA , FRANCARDI VALERIA , LANDI SILVIA , GIOVANNINI LUCREZIA , SIMONI SAURO , ROVERSI PIO FEDERICO , PENNACCHIO FABRIZIO
Published: December 2022

Olive (Olea europaea L.) is a traditional crop of great socioeconomic importance in the Mediterranean Basin. In 2021, a survey was performed in an Italian nursery located in Central Italy where unusual symptoms and widespread dieback had been observed on young potted olive trees. Twigs and branches of all plants affected by dryness showed the presence of the alien bark beetle Xylosandrus compactus. Woody tissues colonized by X. compactus were transferred into the laboratory and several fungi such as Cladosporium perangustum and Neofusicoccum parvum were then identified. In addition to these species, Geosmithia pallida was also reported for the first time in Italy on this plant. Studies on this bark beetle and its associated fungi are currently in progress to further evaluate potential risks for olive cultivation. Key Words: Olea europea, fungi, bark beetles.
Mulheres, religião e nacionalidade na diáspora do Santo Daime em Portugal
Authors: Valamiel Paulina
Published: December 2022

Neste artigo, discutirei “mulheres”, “religião” e “nacionalidade” como eixos interseccionais de grande relevância para o estudo sobre a diáspora do Santo Daime em Portugal. As reflexões partem da análise sobre como estes elementos atuam na configuração deste campo que, a despeito de ser majoritariamente composto por portugueses e portuguesas, tem como figuras mais relevantes, brasileiras daimistas de classe média. Os dados foram coletados durante minhas pesquisas de conclusão de curso e de mestrado, por meio de observação participante e realização de entrevistas semiestruturadas e em profundidade que ocorreram entre os anos de 2017 a 2021. A partir destas pesquisas, foi possível identificar que mulheres, religião e nacionalidade atuam efetivamente nas negociações relativas à diáspora do Santo Daime em Portugal e tecem os contornos dessa religião no país.
Aktivisme Transnasional dalam Prakarsa Being LGBT in Asia: Mobilisasi Gerakan dan Pembentukan Identitas Kolektif
Authors: Andi Muliastuti
Published: December 2022

Diskriminasi dan persekusi terhadap kelompok LGBT di beberapa negara Asia memicu gelombang aktivisme transnasional yang juga difasilitasi oleh globalisasi dan internasionalisasi. Tidak adanya jaminan perlindungan terhadap hak-hak kelompok LGBT, mendorong dibentuknya Prakarsa Being LGBT in Asia sebagai upaya pembelajaran dan pengembangan pemahaman akan Hak Asasi Manusia (HAM) yang dimiliki kelompok LGBT di Asia dengan berfokus di delapan negara prioritas yakni China, Filipina, Indonesia, Kamboja, Mongolia, Nepal, Thailand dan Vietnam. Struktur opresi di masing-masing negara didominasi oleh nilai-nilai agama, budaya (family values), dan konfigurasi politik domestik. Kondisi ini memunculkan ketegangan antara universalisme HAM dan relativisme budaya dalam diskursus gerakan hak-hak LGBT di Asia. Dengan menggunakan konsep aktivisme transnasional dan identitas kolektif, artikel ini berfokus pada pembentukan identitas LGBT Asia dan bagaimana identitas tersebut mempengaruhi diskursivitas gerakan hak-hak LGBT. Identitas sebagai LGBT Asia tidak hanya menjadi katalisator terbentuknya aksi kolektif komunitas LGBT, tetapi juga merupakan outcome dari proses-proses politik dalam gerakan tersebut.
La ´capacidad de acción´ de los espacios arquitectónicos. Estrategias proyectuales de sistemas abiertos
Authors: Ribot Almudena
Published: December 2022

ResumenEste texto abarca la búsqueda de estrategias proyectuales eficaces para ampliar la 'capacidad de acción' de los espacios que proyectamos los arquitectos. Investiga cómo proyectar arquitectura para facilitar la capacidad performativa de los habitantes y usuarios, ampliando su acción y también su responsabilidad como coproductores de nuestras propuestas. Se trabaja en arquitecturas de Sistemas Abiertos más que en proyectos participativos, es decir, desde la invitación a la acción para apropiarse de los espacios en el tiempo y poder reprogramarlos y no tanto desde la implicación inicial de los usuarios como agentes en el proyecto. La exploración está destinada tanto a arquitectos proyectistas y profesores de diseño como a los propios usuarios, de modo que se facilite el conocimiento y aplicación de estos sistemas abiertos en los proyectos. Estas estrategias se discuten, heredando clasificaciones comparables realizadas por otros autores, y finalmente se organizan en tres grupos: redundancia, apropiación y tecnificación, que se ordenan según gradientes de complejidad constructiva o facilidad de uso. Se registran en un diagrama numerosos ejemplos de arquitectura para comprobar la efectividad de esta taxonomía. El diagrama es una categorización no jerarquizada en la que los asuntos y los casos de estudio tienen el mismo valor. Se trata simultáneamente de una taxonomía y un atlas de métodos y casos, un proceso al mismo tiempo deductivo e inductivo. Se prevé dejar este diagrama abierto para poder ser reprogramado en el futuro, acorde a las propias arquitecturas que se estudian.AbstractThis text aims to identify which design strategies are more effective in increasing the “capacity for action” of the spaces designed by architects. It researches how architectural design can foster the performative capacity of the inhabitants and users, widening their actions and responsibilities as co-producers of our proposals. The exploration is aimed both at practicing architects and design teachers as well as the actual users, making these open systems available to be used and harness the potential of working together. The strategies are discussed, taking on similar classifications from other authors, and lastly organized into three group types: redundancy, appropriation, and technification, further organized according to constructive complexity or ease of use. A large number of examples of built architecture are represented in a diagram to test the effectiveness of this taxonomy. The diagram is a non-hierarchical categorization where the matter and the case studies are given equal weighting; it is simultaneously a taxonomy and an atlas of methods and cases, a process at once deductive and inductive. The diagram will be left open to be reprogrammed in the future, much like the architectures studied.
Adipose Tissue Caveolin-1 Upregulation in Obesity Involves TNF-α/NFκB Mediated Signaling.
Authors: Al Madhoun Ashraf , Kochumon Shihab , Haddad Dania , Thomas Reeby , Nizam Rasheeba , Miranda Lavina , Sindhu Sardar , Bitar Milad S. , Ahmad Rasheed , Al-Mulla Fahd
Published: December 2022

Obesity is characterized by chronic low-grade inflammation. Caveolin-1 (CAV1), a structural and functional protein found in adipose tissues (AT), is augmented in obese individuals. We aimed to define the inflammatory mediators that influence CAV1 gene regulation and associated mechanism in obesity. Using subcutaneous AT from 27 (7 lean/20 obese) normoglycemic individuals, in vitro human adipocyte models, and in vivo mice models, we found elevated CAV1 expression in obese AT and a positive correlation between the gene expression of CAV1, tumor necrosis factor alpha (TNF-α), and the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB). CAV1 gene expression was associated with that of proinflammatory cytokines/chemokines, and their cognate receptor (r ≥ 0.447, p ≤ 0.030) but not with anti-inflammatory markers. CAV1 expression was correlated with CD163, indicating a prospective role for CAV1 in adipose inflammatory microenvironment. Unlike wild-type animals, mice lacking TNF-α exhibited reduced levels of CAV1 mRNA/proteins, which were elevated by administering exogenous TNF-α. Mechanistically, TNF-α induces CAV1 gene transcription by mediating NF-kB binding to its two regulatory elements located in the CAV1 proximal regulatory region. The interplay between CAV1 and TNF-α signaling pathway is interesting and has potential as a target for therapeutic interventions in obesity and metabolic syndromes.
In planta genetic transformation to produce CRISPRed high-oleic peanut
Authors: Han Hong Wei , Yu Shu Tao , Wang Zhi Wei , Yang Zhen , Jiang Chun Jiao , Wang Xiu Zhen , Sun Xiu Shan , Wang Chuan Tang
Published: December 2022

In contrast to its normal-oleic counterpart, high-oleic peanut has better keeping quality and multiple health benefits. Breeding high-oleic peanut through conventional means is a tedious process generally requiring several years. Genome editing, however, may shorten the duration. In this study, node injection method was used to transform normal-oleic Huayu 23, a popular peanut cultivar having dysfunctional FAD2A and functional FAD2B, with CRISPR/Cas9 construct targeting FAD2B, and two T0 seeds with over 80% oleic acid and 442A insertion in FAD2B were obtained. A T1 plant grown from the viable T0 seed produced high-oleic seeds. As a genotype-independent, simple and easy method for peanut genetic transformation, node injection has great potential in functional analysis of genes and peanut varietal improvement.
Long-term Administration of CU06-1004 Ameliorates Cerebrovascular Aging and BBB Injury in Aging Mouse Model: A Randomized Control Trial
Authors: Kim Hyejeong , Noh Minyoung , Zhang Haiying , Kim Yeomyeong , Park Songyi , Park Jeongeun , Kwon Young-Guen
Published: December 2022

Background:Age-related changes in the cerebrovasculature, including blood-brain barrier (BBB) disruption and vascular dementia are emerging as potential risks for many neurodegenerative diseases. Therefore, endothelial cells that constitute the cerebrovasculature play a key role in preventing brain injury. Our previous study showed that CU06-1004, endothelial cell dysfunction blocker, prevented vascular leakage and enhanced vascular integrity in ischemic reperfusion injury and normalization of tumor vasculature. Here, we evaluate the effects of CU06-1004 on age-related decline in cerebrovascular function of aged mice brain.Results:In this study, we investigated the protective effects of CU06-1004 on reducing oxidative stress-induced damage in human brain microvascular endothelial cells (HBMECs). HBMECs were treated with hydrogen peroxide (H2O2) to establish an oxidative stress-induced cellular injury model. Pretreatment with CU06-1004 considerably reduced oxidative stress-induced cytotoxicity, ROS generation, senescence-associated β-galactosidase activity, and senescence markers in HBMECs. Additionally, pretreatment with CU06-1004 decreased the expression levels of inflammatory proteins, compared to H2O2treatment alone. Based on the cytoprotective effect of CU06-1004 in HBMECs, we further examined the vascular protective effects of CU06-1004 on cerebrovascular aging in aged mice. Long-term administration of CU06-1004 alleviated age-associated cerebral microvascular rarefaction and cerebrovascular senescence in the aged mouse brain. CU06-1004 supplementation also reduced extravasation of plasma IgG by improving BBB integrity in the aged mouse brain. This improvement in BBB integrity was associated with reduced neuronal injury and cognition memory dysfunction in aged mice. A series of behavioral tests revealed improved motor and cognitive function in aged mice that received CU06-1004.Conclusion:These findings suggest CU06-1004 has promise as a therapeutic for delaying age-related cerebrovascular impairment and improving cognitive function in old age.
Can Green finance, green technologies, and environmental policy stringency leverage sustainability in China: Evidence from Quantile-ARDL estimation.
Authors: Afshan Sahar , Yaqoob Tanzeela , Meo Muhammad Saeed , Hamid Bushra
Published: December 2022

The prime objective of this study is to examine empirically the role of green finance, eco-innovation, and environmental policy stringency to leverage sustainability in China. In doing so, the current study employs the novel QARDL approach using annual data ranging from 2000 to 2017. The study's findings support the existence of a heterogeneous association between the proposed variables. Precisely, the results of QARDL estimation demonstrate that there is a negative association between eco-innovation and ecological footprints; however, the extent of the relationship is quantile dependent. We also discovered an asymmetric negative and significant relationship between green finance and ecological footprints, with findings indicating that a 1% increase in green finance at low quantiles can reduce ecological footprints by 1–4%. However, a 1% increase in green finance at extreme high quantiles leads to a 7% decrease in ecological footprints. Also, for environmental policy stringency, we confirmed that a 1% increase in environmental policy stringency at high quantiles results in a 5–8% reduction in ecological footprints. Finally, the current study offers policymakers helpful suggestions on how to enhance the positive effects of environmentally supported innovation, green finance and stringent environmental policies on the ecosystem.
Comparison the application of 18 F-FDG and 68 Ga-DOTATATE PET/CT in neuroendocrine tumors: A retrospective study
Authors: Hu Xianwen , Li Dandan , Wang Rui , Wang Pan , Cai Jiong
Published: December 2022

Objective: This study aims to compare the efficacy of 68Ga-DOTATATE PET/CT and 18F-FDG PET/CT imaging in the diagnosis, staging and prognosis evaluation of neuroendocrine tumors (NET).
Methodes: We retrospectively reviewed 55 patients (43 patients were initially evaluated; 12 patients were evaluated after treatment) who underwent 18F-FDG and 68Ga DOTATE PET/CT examinations and had pathological results.
Results: In the initial evaluation of 43 patients, 27 patients were pathologically confirmed as NET patients, 23 of which were correctly detected by 18F-FDG, and all 27 patients were detected by 68Ga-DOTATATE. On lession-based comparison, 119 and 168 focal lesions were depicted on 18F-FDG PET/CT and 68Ga-DOTATATE PET/CT, respectively (p =0.0363). In all patients, 68Ga-DOTATATE has higher SUVmax than 18F-FDG, and the SUVmax is negatively related to the NET grade for the former, while the latter is positively related to it.
Conclusion: The value of 68Ga-DOTATATE PET/CT in the diagnosis and staging of NET is higher than that of 18F-FDG PET/CT in NETs, while the value of 18F-FDG PET/CT in NET cannot be ignored, and the combined application of two tracers has important clinical significance for the management of patients with NET.
Health Effects and Clean Up Costs of Love Canal in Niagara Falls, New York
Authors: zelaalem mengistu
Published: December 2022

The Love Canal is a hazardous waste dump-site located in the center of a middle class community in Niagara Falls, New York" which was used as municipal and chemical waste disposal area for residue from the manufacture of chlorinated hydrocarbons from the 1920s until 1953 when it was covered with earth. Perhaps because they didn’t understand the potential risks associated with Hooker’s chemical wastes primary schools and homes had been constructed around the canal .The tragedy of Love Canal were damaged countless families and ruined the environment for many years. The toxic contamination found throughout the soil brought emotional as well as physical pain to those who had purchased homes in the Love Canal area or who had sent their children to its school system. The various additional substances discovered at Love Canal produce a range of acute, sudden symptoms as well as chronic or long term health problems. Proper disposal of hazardous waste is important in protecting the public health. Site selection and site preparation are important factors to be considered for hazardous waste disposal. Overall, the chemical cleanup process is time consuming and costly and this is why it is so important to dispose of toxic waste in proper facilities where the substances will not come into contact with people and pollute their land and water supplies.
Lateral Distal Femoral Condyle as a Precise Reference for Distal Femoral Resection in Total Knee Arthroplasty for Severe Varus Knee Osteoarthritis
Authors: Wei Maozheng , Hao Kuo , Kang Huijun , Kong Lingce , Wang Fei
Published: December 2022

Purpose

Bone resection was highly valued in total knee arthroplasty (TKA), but how to determine the amount of distal femur resection is still controversial. The purpose of this study was to explore how to use lateral condyle as a reference for distal femoral osteotomy in TKA.

Method

Imaging data from 118 nonarthritic subjects and 123 osteoarthritis (OA) subjects were used to assess the cartilage wear pattern of the distal femur in varus knees. Measurements were performed on three-dimensional reconstruction after virtual bone cutting. The difference between the resection amount of distal (0°) and posterior (90°) was calculated when the medial condyle was used as a reference in OA patients. The osteotomy amount on lateral was calculated in nonarthritic subjects when the medial condylar osteotomy was consistent with the thickness of the implants.

Results

In 43% of OA patients, there was༞1mm difference between the 0° and 90° in medial condyle cartilage, and no difference was observed in lateral. When using medial condyle as a reference for osteotomy, there was a difference of 1.3 ± 0.56 mm between the resection amount of 0° and 90°, and the difference was 0.24 ± 0.27 mm when using lateral condyle. Statistical analysis showed that there was a linear correlation between the resection amount of lateral condyle and mechanical lateral distal femoral angle (mLDFA) in nonarthritic subjects (R = 0.72, p<0.001).

Conclusions

Using the lateral condyle as the reference for distal femoral osteotomy is more suitable for the cartilage wear pattern of the varus knee. The position of cutting guide can be adjusted by preoperative measurements of mLDFA.
Filaggrin insufficiency renders keratinocyte-derived small extracellular vesicles capable of modulating CD1a-mediated T cell responses
Authors: Kobiela Adrian , Hewelt-Belka Weronika , Frąckowiak Joanna E , Kordulewska Natalia , Hovhannisyan Lilit , Bogucka Aleksandra , Etherington Rachel , Piróg Artur , Dapic Irena , Gabrielsson Susanne , Brown Sara J , Ogg Graham S , Gutowska-Owsiak Danuta
Published: December 2022

The promoting effect ofFLGloss-of-function mutations on the development of atopic dermatitis (AD) signifies the role of filaggrin in the formation of a protective skin barrier;FLGmutations are also linked to asthma, food allergy and allergic rhinitis despite the absence of the protein in the affected tissues (lungs, intestines, and the majority of the nasal mucosa). AD patients suffer from chronic inflammation and recurrent skin infections; inflammation often precedes the appearance of spatially distant allergic manifestations. Here we show that exosome-enriched small extracellular vesicles (sEVs) secreted by filaggrin-knockdown keratinocytes are extensively remodelled as a consequence of the abnormal keratinocyte differentiation process. This alteration modulates the sEV capacity to promote type 1 and type 2 CD1a-dependent T cell responses by direct effects on self-lipid neoantigen generation; both modulating the amount of permissive (stimulatory) and non-permissive (inhibitory) CD1a ligands released from the sEV membranes by phospholipase A2. We found that this aberrant sEV lipid composition reflects a generalised cellular lipid bias with downregulation of multiple enzymes of lipid metabolic pathways, observed both in filaggrin knockdown keratinocytesin vitro, and in the skin of AD patients. Provision of modulatory ligands by sEVs secreted on a filaggrin insufficiency background, impeding both homeostatic autoreactive and protective antimicrobial CD1a-mediated type 1 and enhancing type 2 T cell responses provides basis for reduced tissue integrity and pathogen clearance and perpetuates inflammation in AD skin as well as in distant tissues to which sEVs are transferred by systemic circulation.
Objective Aspect of Corpus Delicti for Water-Transport Crimes Provided for by Article 263 of the Criminal Code of Russia
Authors: Il'in Nikolay
Published: December 2022

Crime is a diverse phenomenon; as a result, different branches of legal science give it different definitions. This article features violations of water transport safety rules, which have received almost no scientific attention in the past few decades. However, investigators often have to deal with difficulties in establishing some characteristics of the objective aspect of the water-traffic-related crime. The research objective was to review available publications and study judicial practice on the corpus delicti of crimes defined by Article 263 of the Criminal Code of Russia in the sphere of water transport. The author relied on standard methods of analysis, synthesis, and generalization, as well as on the statistical method. The research revealed the role of transport forensic examination in the establishment of the objective aspect of the corpus delicti of water-traffic-related crimes under Article 263 of the Criminal Code of Russia. The investigation of such crimes is associated with the need to establish the violations of traffic standards, as well as the causal link between the violations and the consequences, which is impossible without a competent transport forensic examination.
MULTİPL SKLEROZLU BİREYLERDE STABİLİTE LİMİTLERİ VE DÜŞME RİSKİ ARASINDAKİ İLİŞKİNİN İNCELENMESİ
Authors: ÖZVAR Güngör Beyza , AYVAT Ender , KILINÇ Muhammed
Published: December 2022

Amaç: Bu çalışmanın amacı, Multipl Skleroz (MS)’lu bireylerde stabilite limitleri (SL) ile düşme riski arasındaki ilişkiyi incelemektir.

Yöntem: Çalışmaya 18-50 yaş aralığında, Expanded Disability Status Scale (EDSS) skoru ≤ 4, son 6 ay içerisinde atak geçirmeyen ve son 6 ay içerisinde düşme hikâyesi olan 30 MS’li birey dâhil edildi. Bireylerin demografik bilgileri kaydedildi. Dört yöndeki (anterior, posterior, lateral- sol, sağ) SL, Bertec Balance Check ScreenerTM (Model BP5050; Bertec Corporation, Columbus, OH, USA) ile değerlendirildi. Düşme riski ise Zamanlı Kalk ve Yürü Testi (ZKYT) ile değerlendirildi. Dört yöndeki SL ile ZKYT skoru arasındaki ilişkileri incelemek için Spearman korelasyon testi kullanıldı.

Sonuçlar: Çalışmaya katılan 30 bireyin (18 kadın, 12 erkek) yaş ortalaması 37,66±8,86 yıl idi. Anterior-posterior SL ile ZKYT skorları arasında negatif yönde iyi derecede (r =-0,616), lateral solsağ SL ile ZKYT skorları arasında negatif yönde orta derecede (r =-0,463) anlamlı bir ilişki bulundu (p
Artificial Intelligence Assisted Fabrication of 3D, 4D and 5D Printed
Formulations or Devices for Drug Delivery
Authors: Sharma Kiran Singh
Published: December 2022

5D & 4D printings are an advanced version of 3D printing class and are one of the most
revolutionary and powerful fabrication methods used for preparing innovative structures and solid substances
using precise additive manufacturing technology. It captures the imagination of one with its
potential to produce flexible designing and fabrication of innovative products with high complexity and
speed. This technology with the assistance of AI (Artificial Intelligence) facilitates real-time sensing,
adapting to change, and predicting the state of printing. 3D printing works by employing advanced materials
utilizing a computer aided design with tomography scan under AI control which deposits printing
material in accordance with the nature of a file usually in STL format, but it requires time for printing.
This shortcoming can be overcome by 4D printing where smart materials are incorporated with time as
4th dimension. This technique has self-repair and self-assembly properties that will save around 80% of
time. Some printed materials are made sensitive to temperature, humidity, light, and other parameters so
that they can respond to stimulus, but it’s one limitation of not being able to print complex shapes having
curved surfaces can be overcome by utilising 5D printing where additive manufacturing is done by
rotation of extruder head and rotation of print bed to print in 5 different axes. This review evaluates the
prospective of these techniques with AI interference in medicine and pharmacy, with its effective and
efficient production for the required design precision.
Chemical Modifications of Pyridoxine for Biological Applications: An
Overview
Authors: Sharma Abha , Pawar Rajashree , Chaudhran Preeti , Pandey Dheeraj
Published: December 2022

Pyridoxine and its derivatives, pyridoxamine, and pyridoxal have been recognized for more than 70 years and are known for regulating cellular biology and metabolism. During the past few decades, the anti-oxidant and anti-inflammatory properties of pyridoxine and its vitamers were explored. However, an interesting turnabout was observed in pyridoxine chemical modification in the last two decades. The various important pathophysiological aspects of pyridoxine and its deriva-tives on several cellular systems have been discovered by researchers. Recent findings have shown that many diseases, like cancer, diabetes, hypertension, tuberculosis, epilepsy, and neurodegenera-tive diseases are linked to the alteration of pyridoxine. Herein, our main focus is to review the im-portance of pyridoxine and its derivatives obtained by various chemical modifications, in various disease areas and to recognize important directions for future research.
Proteomics of the Skin Secretion of Pulchrana glandulosa (Anura:
Ranidae) (Boulenger, 1882), Langkawi Island, Kedah, Peninsular Malaysia
Authors: Shahrudin Shahriza , Ong Dasi , Ismail Mohd Nazri
Published: December 2022

Background:

The advancement of proteomics studies leads to various benefits in research.
However, in Malaysia, proteomics studies are still in their early stage.

Objective:

Four adult Pulchrana glandulosa individuals were collected from the stream of Temurun
Waterfall for their proteomics information.

Methods:

These frogs’ skin secretions were collected, extracted, and analysed for their protein antimicrobial
peptide compounds and biomedical potentials using liquid chromatography-mass spectrometry.

Results:

Forty-six proteins had been identified from the skin secretion of this species. They contained
unreviewed proteins, enzymes, AMPs, receptors, regulatory, transport, hormone, and developmental
proteins. In addition, 11 AMP had been identified, consisting of esculentin-2, brevinin 1, and other
AMPs.

Conclusion:

These proteins and AMPs have a wide range of biomedical importance, such as antimicrobials,
anti-tumour, anti-cancerous, anti-viral, wound healing, anti-inflammation, anti-ageing and
maintaining homeostasis.
Gene Expression Network and Circ_0008012 Promote Progression in
MLL/AF4 Positive Acute Lymphoblastic Leukemia
Authors: Tang Yan-Lai , Su Jia-Yin , Luo Jie-Si , Zhang Li-Dan , Zheng Li-Min , Liang Cong , Wang Li-Na , Li Yu , Fan Zhong , Huang Dan-Ping , Sun Panpan , Luo Zhenhua , Qi Ning Hao , Lan Jing-Jing , Zhang Xiao-Li , Huang Li-Bin , Luo Xue-Qun
Published: December 2022

Background:

Acute lymphoblastic leukemia with MLL/AF4 rearrangement remains a
major hurdle to improving outcomes. Gene network and circRNAs have been found to participate
in tumorigenesis, while their roles in leukemia still need to be explored. Recent patents have
shown that circRNAs exhibit the markers for the children ALL, although the target and related
mechanism remain to be elucidated.

Objective:

This study aims to explore the possible targets and mechanisms of ALL with MLLAF4
rearrangement.

Methods:

We first generated a gene network focusing on MLL-AF4 rearrangement. Cell viability
was determined with Cell Counting Kit-8 assay. The cell apoptosis was tested by the Annexin
V/PI assay. The RNA-protein complexes were analyzed by qRT-PCR, and the pathway proteins
were analyzed by western blot.

Results:

This gene network was associated with biological processes, such as nucleic acid metabolism
and immunity, indicating its key role in inflammation. We found that circ_0008012 was upregulated
in MLL/AF4 ALL cells and regulated cell proliferation and apoptosis. Further computed
simulation and RIP showed that IKKβ was the strongest protein in the NF-κB pathway binding
with circ_0008012. As a result, possible regulation of circ_0008012 is suggested by binding IKKβ
in the IKKα:IKKβ:IKKγ compound, which then phosphorylates IκB and activates NF-
κB:p65:p300 compound in cell nucleus, thereby leading to leukemia.

Conclusion:

We identified a gene network for MLL/AF4 ALL. Moreover, circ_0008012 may be a
therapeutic target for this subtype of ALL.
Arnicolide D Inhibits Oxidative Stress-induced Breast Cancer Cell Growth and
Invasion through Apoptosis, Ferroptosis, and Parthanatos
Authors: Wen Wei , Jin Ke , Che Ying , Du Lin-Yao , Wang Li-Na
Published: December 2022

Background:

Breast cancer is the most common malignant tumor in women, and its pathogenesis is very
complicated. More and more studies have found that Traditional Chinese Medicine plays an important role in tumor
prevention.

Objective:

To investigate the mechanism of arnicolide D isolated from Centipeda minima in breast cancer.

Methods:

Cell Counting Kit-8 (CCK-8), western blot, RT-qPCR, ELISA, flow cytometry, and Transwell were used to
detect the effect of arnicolide D on the biological function of breast cancer cells.

Results:

Arnicolide D promoted reactive oxygen species (ROS) production and induced a decrease in mitochondrial
membrane potential in breast cancer cells, thereby inhibiting cell viability and increasing lactate dehydrogenase (LDH)
release. Arnicolide D activated the classical apoptosis pathway to induce cell apoptosis; it significantly promoted
PARP-1 expression, enhanced the nuclear translocation of apoptosis-inducing factor (AIF), and reduced the expression
of AIF in mitochondria, indicating that it can induce the occurrence of parthanatos in a ROS dependent manner. In
addition, arnicolide D down-regulated glutathione peroxidase 4 (GPX4) expression and increased the accumulation of
Fe2+ and malondialdehyde (MDA), thereby activating ferroptosis. Apoptosis inhibitor, ferroptosis inhibitor, PARP
inhibitor, PARP-1 siRNA, AIF siRNA and GPX4 overexpression vector significantly attenuated the inhibitory effect of
arnicolide D on cell viability and reduced LDH release, which indicates that arnicolide D inhibits breast cancer cell
growth by inducing apoptosis, parthanatos and ferroptosis. Arnicolide D also reduced breast cancer cell invasion and
inhibited the expression of matrix metallopeptidase (MMP)-2 and MMP-9.

Conclusion:

Arnicolide D can activate a variety of cell death modes by inducing oxidative stress, thereby inhibiting
the growth and invasion of breast cancer cells, indicating that arnicolide D has a good anti-tumor effect.
Assessment of Learning Approaches of Saudi Dental Students Using the Revised Two-Factor Study Process Questionnaire: A Cross-Sectional Study
Authors: Alahmari Fatemah , Basudan Amani , Shaheen Marwa
Published: December 2022

Purpose:

The aim of this study was to assess the learning approaches of undergraduate dental students in Saudi Arabia.

Methods:

This was a cross-sectional study in which an electronic questionnaire using the Biggs Revised two-factor Study Process Questionnaire (R-SPQ-2F) was completed by 222 undergraduate dental students from 1st year to 5th year. R-SPQ-2F contains 20 items to measure learning approaches through a structural model contrasting deep and surface learning.

Results:

The mean value of the deep approach was higher among 4th- and 5th-year students than among 1st-, 2nd-, and 3rd-year students. The mean values of the surface approach in male subjects and subjects with lower grade point averages were statistically significantly higher than those of the deep approach.

Conclusion:

This study highlights that dental students have a greater tendency to adopt the surface approach in their preclinical years and in the 3rd year when they experience a transition to clinical training. A deep approach to learning was mostly adopted among 4th- and 5th-year dental students. The surface approach was higher among male than female students. Students who used a deep approach had higher academic achievement than students who used a surface approach.
Portland Cement: An Overview as a Root Repair Material: Applications and Various Modifications
Authors: Shahi Shahriar , Fakhri Elaheh , Dizaj Solmaz Maleki , Salatin Sara , Sharifi Simin , Rahimi Saeed
Published: December 2022

Background:

Portland cement has promisingly been utilized for the reconstruction of root perforation and bone defects, although its key drawbacks, including low mechanical properties and radiopacity as well as long setting time, necessitate pragmatic modifications.

Objective:

The main objective of this review was an overview of portland cement as a root repair material, its applications and various modifications.

Methods:

The electronic search of the literature was done on the Pubmed and Google Scholar databases with the keywords of Portland cement, carbon nanotube, graphene oxide, MTA, pulp capping, and root repair material.

Results:

The first part of this paper presents the data published in the literature on applications of Portland cement in endodontic situations, including vital pulp therapy, root perforation repair, root canal filling and root-end filling following apical endodontic surgery. This bioactive endodontic cement has shown promising success rates compared to mineral trioxide aggregate (MTA), however, considerable modifications are required in order to improve its clinical performance and expand its application scope as a root repair material. Hence, nano-reinforcements (graphene oxide, carbon nanotube, silica and hydroxyapatite) and extensive chemical modifications incorporated into Portland cement composition to produce innovative bio-dental materials with superior rheological properties have been discussed. Moreover, the current knowledge of the microstructure, mechanical properties and durability of nanomaterial-incorporated cement has been summarized. Ultimately, this article outlines the main points of animal and clinical studies on resin-modified Portland cement (TheraCal) as a pulp capping material and suggests further investigations prior to marketing authorization.

Conclusion:

It can be concluded that Portland cement has the potential to be used as an acceptable pulp capping material with the least complaints in the long term.