bluuebunny/crossref_metadata_2025 huggingface dataset:
Perceptron Collaborative Filtering
Authors: Chakraborty Arya
Published: February 2023

Abstract: While multivariate logistic regression classifiers are a great way of implementing collaborative filtering - a method of making automatic predictions about the interests of a user by collecting preferences or taste information from many other users, we can also achieve similar results using neural networks. A recommender system is a subclass of information filtering system that provide suggestions for items that are most pertinent to a particular user. A perceptron or a neural network is a machine learning model designed for fitting complex datasets using backpropagation and gradient descent. When coupled with advanced optimization techniques, the model may prove to be a great substitute for classical logistic classifiers. The optimizations include feature scaling, mean normalization, regularization, hyperparameter tuning and using stochastic/mini-batch gradient descent instead of regular gradient descent. In this use case, we will use the perceptron in the recommender system to fit the parameters i.e., the data from a multitude of users and use it to predict the preference/interest of a particular user
Crystalline: A Blockchain based Donation System
Authors: Ghosal Pariksheet
Published: February 2023

Abstract: Charity is an act of kindness, where people who financially capable are donate their money or assets to needy people or organizations that help people. Various unfair frauds and scams based on charity have been witnessed because of that, people who want to donate hesitate before donating their money. We will try to provide them with a more trustworthy and reliable environment for donation with transparency using blockchain technology. In the past two or three years, we all have seen the rise of cryptocurrencies like Bitcoin, Ethereum, etc, and other new things like NFTs, due to which awareness among people has increased about blockchain. People have shown their trust by adapting and implementing cryptocurrencies.
PCOS Detection: A Study of the Literature
Authors: Deodikar Sayali , Shaikh Asma , Jadhav Shraddha , Joshi Aishwarya , Mutakekar Sejal
Published: February 2023

Abstract: PCOS or Polycystic ovary syndrome is a syndrome that happens during the reproductive stage. This occurs when the women’s ovaries produce a higher androgen hormone level. Many women face the issue of infertility. This problem usually occurs due to PCOS. Higher levels of androgen hormone stop the process of ovulation leading to infertility and gynaecological cancer. Though the rate of arising this disease is lower as compared to other diseases, it can cause serious health issues when remaining untreated. Doctors manually review the ultrasound reports and check the number of follicles and their geometrical properties. The detection process of PCOS may consume a lot of time. Technology has changed the health- care sector. Deep learning is a field of machine learning which works on a principle similar to how the human brain works. Neural networks and machine learning algorithms are one of the technologies that are used in critical disease detection. This paper focuses on reviewing the literature and gives insights into the previous methodologies for PCOS detection systems.
A Study on Change Trends of Educational Contents of Low Birth Rate and Population Aging in the School Textbooks in Korea: Focusing on Middle School textbooks of social studies
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Jang Hwi-Chang , Gim Chae-Chun
Published: February 2023

Objectives The purpose of this study is to analyze the change trends in the educational contents of low birth rate and population aging in Middle School textbooks of social studies with the revision of subject curriculum.
Methods First, quantitative changes of educational contents such as the number of units, activities, and pages dealing with the contents of low birth rate and population aging were analyzed, and second, qualitative changes of educational contents regarding low birth rate and population aging were analyzed.
Results First, as the curriculum was revised repeatedly, the number of units, activities, and pages dealing with the educational contents of low birth rate and population aging increased significantly. Second, the educational content of low birth rate and population aging has changed from the presentation of fragmentary backgrounds, causes, or abstract countermeasures to the presentation of systematic explanations including various causes and economic, social and cultural measures.
Conclusions it is still problematic whether educational contents of low birth rate and population aging account for an appropriate portion of the entire textbook, and it needs to be studied further whether all the relevant causes and solutions are sufficiently dealt with in the school textbooks.
An Analysis of Pre-service Science Teachers’ Conceptions of Work: In the Cases that the Displacement of Point of Application Differs from the Displacement of Center of Mass
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Ji Byeong-kwan , Yun Seokmin , Choi Hyukjoon
Published: February 2023

Objectives The purpose of this study is to investigate pre-service science teachers’ definitions of work and conceptions of work in situations that the displacement of the point of application differs from the displacement of the center of mass.
Methods 38 pre-service science teachers were asked to describe the definition of work through a pre-test. They were asked what work done on the object by the force is, when the displacement of the point of application does not coincide with the displacement of the center of mass. Right after pre-test, simple reading materials were provided, and post-test was conducted two weeks later. After that, the results of the pre- and post-test were compared to find out the change in the definition and concept of work.
Results In the definition of work described by pre-service science teachers, there was little use of energy transfer or displacement of the point of application. In a problem situation where the displacement of the point of application does not match the displacement of the center of mass, especially in the items that work done by force is not zero, it was difficult for them to calculate work. Pre-service science teachers with scientific conception of work were found to have scientific work definition.
Conclusions Most pre-service science teachers did not have scientific work definition, and their conceptions of work were not scientific in problem situations that the displacement of the point of application don’t match the displacement of the center of mass. The use of scientific work definition helped to have scientific concept of work.
Does COVID-19 Pandemic Bring the Changes in Schooling Satisfaction of Elementary School Students?
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kwon Dongtaik , Kim Hyun-wook , Nam mi , Choi Jiyeon
Published: February 2023

Objectives The purpose of this study is to analyze the factors affecting school life satisfaction of elementary school students before and after the COVID-19 pandemic, and to identify influence factors affecting School Life Satisfaction.
Methods On school life satisfaction in K province from 2019 to 2022, a survey measuring democratic school culture, learning-centered education, and communication and caring community as influencing factors for school life satisfaction as a dependent variable targeting 5th and 6th graders in elementary school was conducted, and the final 4,843 response data were analyzed. The collected data were analyzed using the SPSS WIN 22.0 program.
Results It is estimated that elementary school students’ satisfaction with school life did not change at the level of general concern before and after COVID-19. Also, it can be seen that it increases, and among the sub-influencing factors(democratic school culture, learning-centered education, and communication and caring community), it can be seen that the democratic school culture factor had the greatest impact on elementary school students' satisfaction with school life.
Conclusions There is a research significance in providing policy implications and basic data for school innovation in order to improve the quality of life and happiness of students through school education.
Influence of Confidence in Performance of Patient Safety Management and Clarity of Communication on Behavior of Patient Safety Management in Nursing Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Kyung Ae , Mun Mi Yeong
Published: February 2023

Objectives This study was to investigate the influence of confidence in performance of patient safety management and clarity of communication on behavior of patient safety management by nursing students.
Methods Data were collected using structured questionnaires from 122 grade 4 with clinical practice experience enrolled in nursing departments at 2 universities located in Chungbuk and kangwon. For the collected data, descriptive statistics, t-test, ANOVA, Pearson correlation coefficients, and hierarchical regression analysis using SPSS/WIN 26.0 statistical program.
Results Confidence in performance of patient safety management had a statistically significant positive correlation with clarity of communication (r=.645, p<.001) and behavior of patient safety management (r=.694, p<.001). Clarity of communication also had a statistically significant positive correlation with behavior of patient safety management (r=.833, p<.001). As a result of hierarchical regression analysis, the factors significantly influencing the behavior of patient safety management were Confidence in performance of patient safety management (β=.27, p<.001) and clarity of communication (β=.65, p<.001), with a total explanatory power of 75.2%.
Conclusions In order to promote the behavior of patient safety management nursing students, it is necessary to develop an educational program can improve clarity of communication and confidence in performance of patient safety management. Also, it is necessary to enhance clarity of communication and confidence in performance of patient safety management by increasing immersion attitude and activeness in relation to the experience through the actual simulation practice class.
ОРГАНИК ЭЛЕКТРОЛЮМИНЕСЦЕНТ ТӨХӨӨРӨМЖИД ЯВАГДАХ ДЕГРАДАЦИЙН ПРОЦЕССЫН АТОМЫН ХҮЧНИЙ МИКРОСКОПЫН СУДАЛГАА
Authors: Бадамгарав П. , Сүндэрьяа Б. , Сугармаа А , Мөнх-Эрдэнэ Э. , Ганзориг Ч.
Published: February 2023

Органик электролюминесцент (EL) төхөөрөмжийн судалгаа болон үйлдвэрлэх технологийн явцад тулгарч буй томоохон асуудлуудын нэг болох ажиллах хугацаа, тогтворжилтыг бууруулдаг гол хүчин зүйл нь деградацийн процесс, түүний үүсэх механизмыг судлах явдал байдаг. Деградацийг бууруулах, дагалдах процессуудыг зогсоох зэрэг судалгааны ажлууд хийгдсээр байгаа хэдий ч одоогоор энэ асуудлыг бүрэн шийдвэрлэж чадаагүй байна.Иймд энэхүү судалгааны ажлаар индий-цагаан тугалгын оксид (ITO), N,N’-дифенил-N,N’-бис(3-метилфенил)-[1,1’-дифенил]-4,4’-диамин (TPD), хөнгөн цагааны трис(8-гидроксихинолин) (Alq3) болон металл Al электрод ашиглан донор/акцептор бүхий давхар үелсэн нимгэн үеийг вакуумд ууршуулан суулгах аргаар ITO(150 нм)//TPD(50 нм)/Alq3(50 нм)/Al(~100 нм) гэсэн бүтэцтэй органик EL төхөөрөмж гарган авсан. Уг төхөөрөмжийн металл электрод болон органик нимгэн үеийн гадаргууд явагдах деградацийн процессыг орчны чийгшил (~80%) болон температур (өрөөний, 80°С, 120°С)-аас хамааруулан хэмжсэн. Атомын хүчний микроскоп (AFM)-ийн аргыг ашиглан органик нимгэн үед үүсэх морфологийн өөрчлөлт, кристаллжих процессын судалгааг хийж гүйцэтгэсэн.Судалгаанд ашиглагдсан органик EL төхөөрөмжийг тогтмол хүчдэлээр ачаалж үйлчлэхэд металл Al электродын гадаргууд бөмбөлөг хэлбэртэй бүтэц (өөрөөр хэлбэл, катодын салалтын процесс) ажиглагдсан бөгөөд мөн давхар үелсэн органик нимгэн үеийн гадаргууд болон гүнд люминесценц үзүүлдэггүй толбо буюу хар нүх (dark spot) үүсэх деградацийн процессын судалгааг AFM аргаар хийж гүйцэтгэсэн болно.
Defining “Men’s Health”
Authors: White Alan , Connell Raewyn , Griffith Derek M. , Baker Peter
Published: February 2023

A definition is required for men’s health that captures current thinking around men and their health and wellbeing globally. A new definition of men’s health should reflect greater complexity than that has existed in previously accepted, over-simplistic definitions of what constitutes “men’s health.” In addition, the most commonly used definitions in the field that originated from the westernised countries of the Global North do not seem to be inclusive of the heterogeneity among a significant proportion of the world’s population. Definitions are important as they help drive academic endeavour, practice and policy; they also help shape organisations working in men’s health and, as such, they need to be as broad as possible. This paper outlines the limitations and conceptual concerns in the current definitions and argues for a more inclusive definition.
Antibacterial Potential of Marine Brown Algae Turbinaria Conoides Against Bacteria Associated with Diabetic Foot Ulcer
Authors: Chitrikha Suresh T. , Poonguzhali T. V. , Anuradha V. , Bharathi S. , Ramesh B. , Suresh G.
Published: February 2023

The marine brown algae Turbinaria conoides was extracted with different solvents, viz., acetone, ethanol, methanol and distilled water. The extracts were screened for the presence of various phytochemicals and examined for antibacterial activity by agar well diffusion method. Diabetic foot ulcer (DFU) associated bacteria and their respective standard strains, such as Staphylococcus aureus ATCC 5923, Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae ATCC 700603 and Enterococcus faecal ATCC 25922 were used as test bacteria. Among the different solvent extracts, the aqueous extract possessed the maximum zone of inhibition against both test and standard bacterial strains. The minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of the aqueous extract against test pathogens were 128-4μg. The eluent mixture for separating the active fraction was selected by thin layer chromatography (TLC), which was found to be n-hexane: ethylacetate (6:4) with a maximum of four spots. In column chromatography, 25th -27th-minute fractions showed maximum antibacterial activity against all the DFU bacterial strains. Our study aims to find the use of T. conoides for treating DFU-associated bacterial infections. The objectives include exploring different solvent extracts of T. conoides for antibacterial activity and characterization of bioactive metabolite.
Hospital-Acquired Venous Thromboembolism in Children with Sickle Cell Disease
Authors: Agarwal Shreya , Foster Kayla L. , Johnson Shaniqua , Shapiro Mary , Han Hyojeong , Scheurer Michael , Airewele Gladstone , Sartain Sarah E.
Published: February 2023

Objectives: Sickle cell disease (SCD) is well recognized as a
hypercoagulable state, however venous thromboembolism (VTE) risk factors
in children remain largely unknown. In this study, we aim to describe
the clinical characteristics, outcomes and recurrence of hospital
acquired VTE in patients younger than 21 years of age. Study
Design/Methods: Data were extracted from electronic medical records
over a 10-year period (2011-2021). Data regarding sickle cell genotype,
demographics, reason for admission, location of thrombus, presence of
central venous catheter (CVC), intensive care unit (ICU) admission,
presence of thrombophilia risk factors, resolution of VTE, mortality,
and bleeding outcomes on anticoagulation were collected. Recurrence of
VTE at 1 and 5 years was assessed. Descriptive statistics were used as
indicated. Results: We identified a total of 21 VTE events over
the ten-year study period. Six of these events occurred in those younger
than 12 years of age. Fifteen (71%) VTE events occurred in the HbSS or
HbSβThal genotypes compared to 8 (29%) in HbSC.
Eleven (52%) patients were admitted with acute chest syndrome (ACS).
Most VTE events were associated with ICU admissions (n=13, 62%) and
presence of central venous catheter (n=12, 57%). Major bleeding on
anticoagulation occurred in 10%.All patients had resolution of index
VTE at 12 weeks. Recurrence rate for VTE at 5 years was 13%. One
patient died from the VTE event. Conclusions: Our study
highlights that VTE can complicate SCD in children and young adults.
Hospital acquired VTE were most associated with ICU admission, CVC, and
ACS, but larger studies are indicated to validate our findings.
MicroRNA-21 promotes hypopharyngeal cancer induced transition of bone marrow mesenchymal stem cells to cancer-associated fibroblasts
Authors: he shi fang , wang hao , Zhou Zheng yu , lin wen chao , qian ye chun , Wang Jun
Published: February 2023

Abstract Objective: At present, human bone marrow mesenchymal stem cells
(hBMSCs) used as target vectors for hypopharyngeal cancer is a new
therapeutic direction of great potential. However, hBMSCs would be
transmitted into cancer-associated fibroblasts(CAFs) under the induction
of hypopharyngeal cancer. Here, we aimed to determine whether
microRNA-21(miR-21) in exosomes from FaDu cells would play a role in
hypopharyngeal cancer induced transition of hBMSCs to CAFs. Methods:
qRT-PCR and western blot were employed to investigate expression level
of miR-21 in hypopharyngeal cancer patient samples and FaDu cells. The
exosomes were collected from FaDu cells then isolated and identified.
Cell morphological changes were observed by inverted phase contrast
microscope. Expression level of CAF-related proteins, includingα-SMA and
FAP, were assessed by qRT-PCR and western blot. Cell cycle of hBMSCs
were determined by flow cytometry. Results: MiR-21 expression level was
up-regulated in hypopharyngeal cancer tissue and FaDu cells. Exosomes
from FaDu cells promoted CAFs-like features of hBMSCs, including
up-regulation of α-SMA and FAP and cell morphological changes.
Proportions of hMBSCs in G1 phase significantly decreased, while
proportions of hMBSCs in G2 phase significantly decreased at the
presence of exosomes from FaDu cells. What’s more, miR-21 knock-out in
FaDu cells suppressed transition of bone marrow mesenchymal stem cells
to cancer-associated fibroblasts and reversed the cell cycle change.
Conclusions: Our data showed that miR-21 promotes hypopharyngeal cancer
induced transition of bone marrow mesenchymal stem cells to
cancer-associated fibroblasts. Keywords: Hypopharyngeal cancer, Bone
marrow mesenchymal stem cells, Cancer-associated fibroblasts,
MicroRNA-21, Exosomes
ASSESSMENT OF MATERNAL ABDOMINAL SUBCUTANEOUS FAT THICKNESS (SFT) AS AN INDEPENDENT PREDICTOR OF ADVERSE PREGNANCY OUTCOMES: A PROSPECTIVE COHORT STUDY
Authors: SURENDRAN NILA , GUPTA PRATIKSHA , agarwal utkarsha , SHEKHAWAT PALLAVI
Published: February 2023

Introduction: Obese pregnant women are at increased risk for a
variety of maternal and perinatal complications. The maternal risks
related to obesity include Gestational Diabetes mellitus, Preeclampsia,
increased caesarian sections. The fetus is at risk of stillbirth,
preterm birth and congenital anomalies.This study focuses on the use of
Maternal abdominal subcutaneous fat thickness (SFT) as a surrogate
measure for central obesity as measured by ultrasound, and determining
its efficacy compared to BMI in predicting obesity related pregnancy
complications. Objective: To measure mid-trimester SFT in
antenatal women and establish SFT as an independent predictor of obesity
related adverse pregnancy outcomes Methods: This was a
prospective cohort study. 150 pregnant women between 20-40 years of age
were recruited. Demographic data of each participant was collected from
the OPD. USG for abdominal subcutaneous fat thickness (SFT) was done at
18-22 wks period of gestation.The participants were followed up to
labour. Adverse pregnancy outcomes and their correlation with the SFT
measured was studied. Results: There was significant positive
correlation between BMI and SFT (r=0.591, p<0.001) .A positive
correlation was noticed between BMI and adverse pregnancy outcomes such
as PIH, GDM , preterm birth , postdatism and NICU admissions.SFT
independently showed a positive correlation with the above parameters.
The mean SFT among women without PIH was 11.45 mm, and with PIH was
16.48 mm[p <0.001].Mean SFT were 11.68mm and 16.24 mm
among the ladies without and with GDM
respectively[p<0.001]. The mean SFT for term pregnancies
was 12.06 mm whereas the mean SFT for preterm births was 14.21 showing
positive correlation between SFT and preterm birth. SFT also showed
positive correlation with need for NICU admission for neonates [ SFT
avg being 11.72mm and 14.94 mm in the 2 groups]. A comparative
analysis was done between BMI and SFT regarding their correlation to the
various outcomes. SFT showed higher correlation coefficients for these
variables than BMI, with lower p values suggesting more statistical
significance. Conclusion: BMI showed a positive correlation
with adverse pregnancy outcomes in mother as well as fetus, SFT showed
greater and more statistically significant correlation for adverse
outcomes. Thus it was concluded that SFT is a better independent
predictor of obesity related adverse pregnancy outcomes.
Evaluating stony coral tissue loss disease intervention success through whole-transcriptome gene expression profiling
Authors: Studivan Michael , Eckert Ryan , Shilling Erin , Soderberg Nash , Enochs Ian , Voss Joshua
Published: February 2023

Stony coral tissue loss disease (SCTLD) remains an unprecedented disease
outbreak due to its high mortality rate and rapid spread throughout
Florida’s Coral Reef and wider Caribbean. A collaborative effort is
underway to evaluate disease intervention strategies that mitigate the
spread of SCTLD across coral colonies and reefs. We conducted an in-situ
experiment in Southeast Florida to assess molecular responses among
SCTLD-affected Montastraea cavernosa pre- and post-application of the
most widely-used intervention method, CoreRx Base 2B with amoxicillin.
Through Tag-Seq gene expression profiling of apparently healthy,
diseased, and treated corals, we identified modulation of metabolomic
and immune pathways following antibiotic treatment. In a complementary
ex-situ disease challenge experiment, we exposed nursery-cultured M.
cavernosa and Orbicella faveolata fragments to SCTLD-affected donor
corals to compare transcriptomic profiles among clonal individuals from
unexposed controls, those exposed and displaying disease signs, and
corals exposed and not displaying disease signs. Suppression of
metabolic functional groups and activation of stress gene pathways as a
result of SCTLD exposure were apparent in both species. Amoxicillin
treatment led to a ‘reversal’ of the majority of gene pathways
implicated in disease response, suggesting potential recovery of corals
following antibiotic application. In addition to increasing our
understanding of molecular responses to SCTLD, we provide resource
managers with transcriptomic evidence that disease interventions with
antibiotics appear to be successful and may help to modulate coral
immune responses to SCTLD. These results contribute to feasibility
assessments of intervention efforts following disease outbreaks and
improved predictions of coral reef health in Southeast Florida.
Identification of tyrphostin AG879 and A9 inhibiting replication of Chikungunya virus by screening of a kinase inhibitor library
Authors: Tang Hailin , He Yanhua , Pan Zhendong , Liu Yan , Jiang Liangliang , Peng Haoran , Zhao Ping , Qi Zhongtian , Liu Yangang
Published: February 2023

Chikungunya virus (CHIKV) is a globally public health threat. There are
currently no medications available to treat CHIKV infection.
High-throughput screening of 419 kinase inhibitors was performed based
on the cytopathic effect method, and six kinase inhibitors with reduced
cytopathic effects, including tyrphostin AG879 (AG879), tyrphostin 9
(A9), sorafenib, sorafenib tosylate, regorafenib, and TAK-632, were
identified. The anti-CHIKV activities of two receptor tyrosine kinase
inhibitors, AG879 and A9, that have not been previously reported, were
selected for further evaluation. The results indicated that 50%
cytotoxic concentration (CC ) of AG879 and A9 in Vero
cells were greater that than 30 μM and 6.50 μM, respectively and 50%
effective concentration (EC ) were 0.84 μM and 0.36
μM, respectively. The time-of-addition and time-of-removal assays
illustrated that both AG879 and A9 function in the middle stage of CHIKV
life cycle. Further, AG879 and A9 do not affect viral attachment;
however, they inhibit viral RNA replication, and exhibit antiviral
activity against CHIKV Eastern/Central/South African and Asian strains,
Ross River virus and Sindbis virus in vitro.
Real or fake? Verifying protein domain gain and loss events by an automated fact-checking approach
Authors: Thompson Julie D. , Kress Arnaud , Poch Olivier , Lecompte Odile
Published: February 2023

The comparison of protein domain architectures provides insight into the
evolution and function of proteins. By comparing the domains of
different proteins, scientists can identify common domains, classify
proteins based on their domain architecture, and highlight proteins that
have evolved differently in one or more species or clades. Such proteins
are often thought to represent genetic novelty underlying unique
adaptations. However, genome-wide identification of different protein
domain architectures involves a complex error-prone pipeline that
includes genome sequencing, prediction of gene exon/intron structures,
and inference of protein sequences and domain annotations. Here we
developed an automated fact-checking approach to distinguish true domain
loss/gain events from false events caused by errors that occur during
the annotation process. Using genome-wide ortholog sets and taking
advantage of the high-quality human and Saccharomyces cerevisiae
genome annotations, we analyzed the domain gain and loss events in the
predicted proteomes of 9 non-human primates (NHP) and 20 non- S.
cerevisiae fungi (NSF) as annotated in the Uniprot and Interpro
databases. Our approach allowed us to quantify the impact of errors on
estimates of protein domain gains and losses, and we show that domain
losses are over-estimated ten-fold and three-fold in the NHP and NSF
proteins respectively. This is in line with previous studies of
gene-level losses, where sequencing issues or incorrect gene prediction
led to genes being falsely inferred as absent. For the first time, to
our knowledge, we show that domain gains are also over-estimated by
three-fold and two-fold respectively in NHP and NSF proteins. Based on
our more accurate estimates, we infer that true domain losses and gains
in NHP with respect to humans are observed at similar rates, while
domains gains in the more divergent NSF are observed twice as frequently
as domain losses with respect to S. cerevisiae. This study
highlights the need to critically examine the scientific validity of
protein annotations, and represents a significant step toward scalable
computational fact-checking methods that may one day mitigate the
propagation of wrong information in protein databases.
The determination of the impact of emotional advertising appeals on willingness to recycle
Authors:   Vytautas Magnus University, Grigaliunaite Viktorija , Pažeraite Ausra ,   Vytautas Magnus University, Rackauskas Mantautas ,   Vytautas Magnus University
Published: February 2023

The importance of recycling is undeniable for the circular economy and it is one of the main strategies for waste minimization. Therefore, effectively performed encouragement of recycling becomes urgent. Social advertising that promotes recycling is one of the methods to encourage society to reach higher levels of recycling. Thus, it is of interest to determine whether a negative appeal (fear) or a positive appeal (joy) makes a bigger impact on willingness to recycle. Yet, this has rarely been studied directly. Therefore, the scientific problem solved in the article is: how does joy and fear advertising appeals impact willingness to recycle? This paper aims to determine the impact of joy and fear advertising appeals on willingness to recycle. To reach the aim of the article, the implicit association test and questionnaire survey were provided. The analysis of research results revealed that the fear appeal advertisement for recycling seems more interesting, but the implication can be made that a bigger impact on the attitude toward recycling and willingness to act is made by joy appeal advertisement which is preferred unconsciously.
Fun and game theory as motivation in waste sorting process at an individual level
Authors:   Liepaja University, Kolosova Ieva
Published: February 2023

One of the key aspects in the development of a sustainable waste system is respect towards the principles of a circular economy. Despite its complexity, the essential and crucial role in the waste management process is that of an individual. Residents of Latvia face several challenges in the recycling process – lack of infrastructure, knowledge and individual motivation to sort the waste for the common good. European Union has set ambitious goals in regard to waste reduction. If the situation in Latvia does not rapidly improve, it will not achieve these goals.This paper proposes the game theory and a positive been conducted encouragement approach to help improve the situation. A literature review of established theories has and results in a proposal of an informal approach – fun theory. The final section offers a brief overview of four different research studies about waste recycling and individual motivation toward it. A range of theories and motivational aspects related to the problem have been considered and theoretical grounds laid for further and practical research, namely, a unified collection of information in a format of a household waste themed game that could be tested by employing a sample of a Latvian population.
Implementation of agricultural innovation to confirm climate neutrality and related issues
Authors:   Latvia University of Life Sciences and Technologies, Viksnina Vivita , Leibus Inguna ,   Latvia University of Life Sciences and Technologies
Published: February 2023

The European Union (EU) and its Member States have set themselves the goal of achieving climate neutrality throughout the EU by 2050. The agricultural sector is one of the emitters of greenhouse gases. To meet its climate neutrality targets of reducing global temperature rise to below 2°C and limiting it to 1.5°C, the EU has adopted the Green Deal and the Farm to Fork strategy based on it. The set goals create the need to develop and implement new innovations. The agricultural sector will face a number of innovative approaches in the future, including the digitalization of agriculture and the use of biotechnology, expertise from microbiology. The agricultural sector will face significant changes in farming methods. The aim of the study is to explore agricultural innovations to promote climate neutrality, the tasks are to assess the differences in the definition of innovation, the problems of their implementation and the challenges in agricultural crop production and to identify the current situation in Latvian agriculture compared to Lithuania and Estonia in terms of greenhouse gas emissions (GHG) emissions. The share of GHG generated by agricultural sector in Latvia is relatively high compared to the EU average. Among the Baltic States, the share of Latvia's GHG emissions in Latvia is almost 20%, which is higher than in Estonia, but lower than the GHG emissions generated by the Lithuanian agricultural sector. According to Food and Agriculture Organization (FAO) data, the Lithuanian government has invested the most in agriculture compared to Estonia and Latvia. Investments of Latvian and Estonian governments in agriculture can be assessed as similar.
Pemanfaatan Platform Digital sebagai Media Pemasaran Growol
Authors: Lukisworo Agustinus Aryo
Published: February 2023

Kuliah Kerja Nyata (KKN) Periode 79 of Universitas Atma Jaya Yogyakarta has been done from April to May 2021. On this period, the KKN was deployed on two Daerah Istimewa Yogyakarta regencies, Kulon Progo and Gunung Kidul. Kelompok 5 (Fifth group) of Unit A of this KKN, was assigned to Kalirejo Village, Kapanewon Kokap, Kulon Progo. Due to the Covid-19 pandemic, this period of KKN was carried out through online mode, without fieldwork and face-to-face interaction. Thus programs of this KKN was created upon secondary data which obtained by online investigations. Findings show that Kalirejo Village has a huge amount of potencies that fall into two categories, entrepreneurship, and socio cultural potency. Among that Kalirejo Village potencies, growol became an interesting potency to develop, particularly through a combination with digital platform utilization as a marketing medium for that traditional food. Hopefully, the digital marketing development will rise up the popularity and the demand of growol, dan lead to the Kalirejo Village economic development.
Optimalisasi Potensi Desa Untuk Meningkatkan Perekonomian Desa Watugajah
Authors: Ludvianto Meganusa
Published: February 2023

UAJY Community Service based on Society 5.0 is a sustainable step to continue to provide innovation and community service even during the COVID-19 pandemic. Group 78 of the 79 Community Service Program conducted community service in Watugajah Village, Gedangsari District, Gunung Kidul Regency. The purpose of this service is to improve the economy of Watugajah Village by optimizing the village's potential. This service is expected to be able to provide education and information to the community because there are many potentials in Watugajah Village that are not maximized in its operations. Therefore, this optimization aims to increase the added value of the tourism, handicraft, and food processing sectors, especially night mango. The methods used to realize the work program are the method of determining the topic by searching for data related to Watugajah Village information, the method of searching for literature by looking for theories and sources from experts to strengthen related data, methods of making reports, e-books, and videos that will be provided to the community to provide knowledge in improving the economy of the Watugajah Village community, and methods of discussion and guidance carried out together with supervisors. The result is that the community can practice optimizing tourism, crafts, and food processing. Making fertilizers also affect increasing community independence in fertilizer production. The conclusion is that the increase in the potential of the village can encourage the economy of the people of Watugajah Village.
Pemberdayaan Potensi Sumber Daya Alam Pada Desa Sampang Kecamatan Gedangsari Kabupaten Gunung Kidul
Authors: Ludvianto Meganusa
Published: February 2023

In the implementation of the 79 Society 5.0 Real Work Lecture, Atma Jaya Yogyakarta University, the 79 Group created a work program related to empowering the potential of natural resources owned by Sampang Village. This work program aims to improve the local community's economy in the form of biogas and natural potentials in Sampang Village. This type of research was conducted based on direct observation by the group following health protocols and supported from Google sources. The data used in this study are primary data in the form of observations and searches via Google, while secondary data is in the form of journals and searches via Google or the internet. This data source was collected and analyzed qualitatively in Microsoft Word, then understood and assembled the storyline through existing data and collected through Whatsapp Group and Meet Microsoft Teams. Based on the data analysis that has been processed, it is concluded that the KKN Group 79 work program will conduct counseling by increasing natural potential through the tourism sector, namely Luweng Sampang which is a tourist attraction in the form of waterfalls and increasing the potential for biogas through the livestock sector, namely processing goat waste into organic fertilizer to be produced which is then marketed to improve the economy of the people of Sampang Village, Gedangsari District, Gunung Kidul Regency.
Efektivitas Penggunaan Teknologi Komunikasi Terhadap Perkembangan Wisata Desa Candirejo
Authors: Putra Prakasa, S.T., M.Kom. Fedelis Brian
Published: February 2023

Desa Candirejo merupakan salah satu desa yang berada di wilayah kecamatan Semin, kabupaten Gunung Kidul dengan luas sebesar 11,12 Km2. Desa Candirejo memiliki jumlah penduduk sebanyak 7.986 jiwa yang terdiri dari 4.010 jiwa laki-laki dan 3.976 jiwa perempuan. Salah satu potensi yang dimiliki desa Candirejo dibidang pertanian dan wisata, baik potensi wisata alam, budaya, maupun agro. Hal inilah yang menjadi modal dan kekuatan bagi penduduk desa Candirejo untuk mengembangkannya. Melalui program pengabdian, Universitas Atma Jaya Yogyakarta dihasilkan suatu program kerja terhadap perkembangan wisata dengan penggunaan teknologi komunikasi penduduk desa Candirejo. Jenis penelitian yang digunakan adalah riset dokumentasi. Tim dapat mencari segala bentuk data yang tersimpan dalam bentuk arsip foto, surat, hasil rapat, cinderamata, jurnal kegiatan, dan sebagainya. Berdasarkan data yang didapatkan, kemudian dianalisis dan akhirnya akan ditarik sebuah kesimpulan secara metode berpikir induktif. Kesimpulan dari program pengabdian ini diharapkan dapat memberikan informasi dan membantu warga desa Candirejo untuk dapat mengembangkan wisata disana.
Pemanfaatan Hasil Alam Ubi Kayu Pada Desa Umbulrejo, Kecamatan Ponjong, Kabupaten Gunungkidul
Authors: Pratama Yohanes Mario
Published: February 2023

Kuliah Kerja Nyata at Universitas Atma Jaya Yogyakarta for 79th period in the year of 2021 is running online while still paying attention to several things so that activities can continue to run well. Group 36 in Unit H is assigned KKN in Umbulrejo Village, Ponjong District, Gunungkidul Regency, Yogyakarta Special Region Province. The group collected all data from Umbulrejo Village through secondary data, namely searching through various sources on the internet and filtered to find valid data. In Umbulrejo Village, it was found that there was an abundance of natural cassava products that were still not fully utilized. Group 36 has a work program that provides education about the use of natural cassava products into chips. Processed chips will be packaged attractively and the marketing stages will be carried out through several media. The program is also equipped with the creation of e-books and videos to support the sustainable development of Umbulrejo Village. The hope is that Umbulrejo Village can realize the potential of the village it has to serve as a means of progress and welfare of the residents of Umbulrejo Village.
Potensi Desa Bumirejo Kabupaten Kulon Progo pada Bidang Kuliner, Kerajinan, Kesenian, serta Inovasi dalam bidang Pakan Ternak
Authors: Larasati Stephani Rangga
Published: February 2023

AbstrakTerdapat beberapa potensi dari desa Bumirejo yang potensial untuk dikembangkan, pada kajian ini akan dibahas potensi-potensi tersebut, yaitu: (1) Potensi pengolahan jamur tiram; (2) potensi gerabah; (3) potensi kesenian ; dan (4) inovasi pada bidang pakan ternak. Tujuan dari kajian ini antara lain untuk menggali potensi desa Bumirejo, memberikan wawasan dan pengetahuan mengenai pentingnya identitas digital, memberikan panduan dan arahan  menciptakan inovasi produk menggunakan potensi desa Bumirejo, serta menginspirasi masyarakat desa Bumirejo untuk terus melakukan pengembangan potensi desanya. Metode yang digunakan dalam pencarian data adalah dengan kajian pustaka, deskriptif kualitatif. Metode pengumpulan data melalui wawancara dengan Karang Taruna Desa Bumirejo, melalui berbagai literasi buku dan jurnal, serta diskusi dengan ahli. Pengolahan data dilakukan dengan mengadaptasi data dan disesuaikan dengan peluang yang ada. Hasil dari program pengabdian masyarakat ini adalah inovasi produk olahan jamur, berbagai akun media sosial sebagai identitas digital, desain interior pusat gerabah, inovasi cara fermentasi pakan ternak, hingga berbagai usulan program yang dapat dikembangkan secara mandiri oleh masyrakat desa Bumirejo. Diharapkan program pengabdian masyarakat ini dapat memberikan manfaat bagi masyarakat desa Bumirejo dan siapapun yang membaca. Kata Kunci — jamur tiram, gerabah, ferementasi pakan ternakAbstractThere are several potentials from desa Bumirejo  that potentially to be developed, this study will discuss these potentials, namely: (1) the potential for processing oyster mushrooms; (2) potency of pottery; (3) artistic potential; and  (4) innovation in fermentation of animal feed. This program aims to explore the potential of desa Bumirejo, providing insight and knowledge about the importance of digital identity, providing guidance and directions for creating product innovations using the potential of desa Bumirejo, and inspiring the people of desa Bumirejo to continue developing the potential of their village. The method used in data search is literature review, descriptive qualitative. Methods of data collection through interviews with the Karang Taruna Desa Bumirejo, through various literacy books and journals, as well as discussions with experts. Data processing is done by adapting the data and adjusting it to the opportunities that exist. The results of this community service program are innovation of processed mushroom products, various social media accounts as digital identities, interior design of pottery centers, innovations in animal feed fermentation, to various proposed programs that can be developed independently by the people of Bumirejo village. It is hoped that this community service program can provide benefits for the people of Bumirejo village and anyone who reads. Keywords — oyster mushroom, earthenware, animal feed ferementation
Pemanfaatan Limbah Ternak Sebagai Pupuk Organik untuk Mendukung Pengembangan Sektor Pertanian dan Perkebunan Desa Segoroyoso
Authors: Andika Ignatius Putra
Published: February 2023

Pupuk merupakan elemen utama dalam pertumbuhan tanaman, salah satu jenisnya adalah pupuk organik. Pupuk organik merupakan pupuk yang bersumber dari bagian hewan, kotoran hewan, tumbuhan yang sudah mati, atau limbah organik lainnya. Pada Desa Segoroyoso, Kecamatan Pleret terdapat banyak limbah kotoran ternak yang dapat dimanfaatkan sebagai salah satu bahan dasar pembuatan pupuk organik. Pada jurnal ini akan dibahas mengenai proses pembuatan pupuk organik dengan bahan limbah ternak hasil dari kegiatan peternakan Desa Segoroyoso. Metode pembuatan pupuk organik adalah dengan menyusun bahan pembuat kompos secara berurutan yang dimulai dari bawah ke atas. Setelah 3 minggu, kotak kompos dibalik agar susunan kompos yang di bawah menjadi di atas, sehingga dapat tercampur rata. Berikutnya tahapan pembalikan kedua, kompos terlihat sudah menyerupai tanah serta kotoran sudah hancur dan tidak bau. Lalu dilakukan penyaringan dan didiamkan selama 2 minggu. Selanjutnya mengemas kompos kedalam sak plastik dan kompos siap untuk digunakan. Hasil dari pengembangan pembuatan pupuk organik menggunakan bahan dasar limbah ternak dan limbah organik membuat masyarakat memahami efektifitas proses pemanfaatan limbah ternak di Desa Segoroyoso.
Biogenetic Markers for Predicting Response to Immunotherapy in Rheumatoid Arthritis
Authors: H. Jabbar Sara , Mohammed Khairallah A.S , Ali Naael H.
Published: February 2023

Background: TNF-α plays a critical role in the pathogenesis of RA. Gene polymorphisms occurring in this pro-inflammatory cytokine or their receptors may influence responses to biological therapy. Objectives: This study aimed to evaluate the impact of -238G/A(rs361525), -308G/A(rs1800629), -376G/A(rs1800750), +489G/A(rs80267059) SNPs in TNF-α and +587T/G(rs1061622), +884A/G(rs5746032) SNPs in TNFRII genes on responsiveness to TNF inhibitors as well as their effect on serum levels of TNF-α and TNFRII. Subjects and methods: Sixty patients with RA treated with anti-TNF therapy (30 responders and 30 non-responders) were allocated to this study. SNPs in the TNF-α and TNFRII genes were studied by three different techniques: PCR-sequencing, PCR-RFLP, and q-PCR-TaqMan assay. TNF-α and TNFRII serum levels were determined using the ELISA technique. Results: TNF-α -308 (GA), +489 (GA), and TNFRII +587 (TG) genotypes were found to be more associated with non-responsiveness to TNF than homozygous genotypes (OR: 1.3, 2.5, and 2.0, respectively). On other hand, TNF-α -238 and -376 (GA) genotypes, were found to be more associated with TNFi responsiveness than homozygous genotypes (OR: 0.172 and 0.22, respectively). However, none of them reached a significant level. Furthermore, the studied SNPs were found to be unrelated to serum levels of TNF-α and TNFRII. Conclusion: According to our findings, the TNF-α -238G/A, -308G/A, -376G/A, +489G/A, and TNFRII +587T/G, +884A/G SNPs were not significantly associated with the responsiveness of RA patients to biological therapy and had no effect on the serum levels of TNF-α and TNFR.
Application of ZMOT in Meal Kit Business in Indonesia
Authors: Detantra Atreiyu Sianmayo , Mansoor Alvanov Zpalanzani
Published: February 2023

The meal kit business is relatively new in Indonesia. As an initiator in the meal kit business in Indonesia “Black Garlic” failed to deliver its value to the market. Thus, they went bankrupt in 2015. However, after the pandemic, the meal kit business model gained attraction in entrepreneurs' eyes. While they are trying to fit in the market, Masakbox is diving in and trying to find the best practices to win in the meal kit business. This research will discuss the journey of the business in adapting ZMOT (Zero Moment of Truth) for a meal kit business namely Masakbox by briefly discuss about the existing business condition and analyzed using As Is Business Process Map and Value Proposition Canvas. Subsequently, the primary data is gathered from actual customers after they purchase the product and expert recommendations. Finally, the action that Masakbox took to solve the problem by using ZMOT theory and the impact in the business. The impact of ZMOT after analysis and implementation process, Masakbox has redesigned its own business process map and value proposition. Moreover, ZMOT adaptation also impacted in sales performance and brand awareness on its platforms.
Historical Perspective and Current Challenges for Microbreweries on Bacterial Spoilage of Beer
Authors: Thompson Alex , Dawson Paul
Published: February 2023

Beer is an ancient beverage that is more popular today than ever. Craft beer has cemented itself as a staple segment of the larger beer market. Microbreweries and brewpubs make up a large portion of craft beer producers. These smaller scale producers have an increased risk of their beer becoming contaminated by unwanted microorganisms. Although beer is typically considered a microbiologically stable product, beer can still become contaminated with specific bacterial species that are capable of evading beer’s intrinsic antibacterial properties and the processing hurdles of brewing that lower bacterial contamination risk. Research thus far is lacking in protecting the growing community of microbreweries and brewpubs. These producers face a unique set of challenges in protecting their products that larger breweries do not. Solutions need to be identified by new research. This article looks to summarize the current knowledge regarding bacterial contaminations in breweries to facilitate research in the future.