bluuebunny/crossref_metadata_2025 huggingface dataset:
Body weight distortions in an auditory-driven body illusion in subclinical and clinical eating disorders
Authors: Tajadura-Jiménez Ana , Crucianelli Laura , Zheng Rebecca , Cheng Chloe , Ley-Flores Judith , Borda-Más Mercedes , Bianchi-Berthouze Nadia , Fotopoulou Aikaterini
Published: November 2022

Previous studies suggest a stronger influence of visual signals on body image in individuals with eating disorders (EDs) than healthy controls; however, the influence of other exteroceptive sensory signals remains unclear. Here we used an illusion relying on auditory (exteroceptive) signals to manipulate body size/weight perceptions and investigated whether the mechanisms integrating sensory signals into body image are altered in subclinical and clinical EDs. Participants’ footstep sounds were altered to seem produced by lighter or heavier bodies. Across two experiments, we tested healthy women assigned to three groups based on self-reported Symptomatology of EDs (SED), and women with Anorexia Nervosa (AN), and used self-report, body-visualization, and behavioural (gait) measures. As with visual bodily illusions, we predicted stronger influence of auditory signals, leading to an enhanced body-weight illusion, in people with High-SED and AN. Unexpectedly, High-SED and AN participants displayed a gait typical of heavier bodies and a widest/heaviest visualized body in the ‘light’ footsteps condition. In contrast, Low-SED participants showed these patterns in the ‘heavy’ footsteps condition. Self-reports did not show group differences. The results of this pilot study suggest disturbances in the sensory integration mechanisms, rather than purely visually-driven body distortions, in subclinical/clinical EDs, opening opportunities for the development of novel diagnostic/therapeutic tools.
Genome-wide analysis-based single nucleotide polymorphism marker sets to identify diverse genotypes in cabbage cultivars (Brassica oleracea var. capitata)
Authors: Jo Jinkwan , Kang Min-Young , Kim Kyung Seok , Youk Hye Rim , Shim Eun-Jo , Kim Hongsup , Park Jee-Soo , Sim Sung-Chur , Yu Byung Cheon , Jung Jin-Kee
Published: November 2022

Plant variety protection is essential for breeders’ rights granted by the International Union for the Protection of New Varieties of Plants. Distinctness, uniformity, and stability (DUS) are necessary for new variety registration; to this end, currently, morphological traits are examined, which is time-consuming and laborious. Molecular markers are more effective, accurate, and stable descriptors of DUS. Advancements in next-generation sequencing technology have facilitated genome-wide identification of single nucleotide polymorphisms. Here, we developed a core set of single nucleotide polymorphism markers to identify cabbage varieties and traits of test guidance through clustering using the Fluidigm assay, a high-throughput genotyping system. Core sets of 87, 24, and 10 markers are selected based on a genome-wide association-based approach. All core markers could identify 94 cabbage varieties and determine 17 DUS traits. A genotypes database was validated using the Fluidigm platform for variety identification, population structure analysis, cabbage breeding, and DUS testing for plant cultivar protection.
The association between expressive language skills and adaptive behavior in individuals with Down syndrome
Authors: del Hoyo Soriano Laura , Villarreal Jennifer Catalina , Sterling Audra , Edgin Jamie , Berry-Kravis Elizabeth , Hamilton Debra R. , Thurman Angela John , Abbeduto Leonard
Published: November 2022

The primary goal of this study was to determine whether expressive language skills contribute to adaptive behavior (e.g., socialization and daily living skills) in children, adolescents, and young adults with Down syndrome (DS) whilst controlling for age and nonverbal cognitive ability. Expressive language was assessed using the psychometrically validated Expressive Language Sampling (ELS) conversation and narration procedures. The language produced was transcribed and analyzed to yield measures of expressive vocabulary, syntax, and intelligibility. Socialization and daily living skills of participants with DS were measured with the Vineland Adaptive Behavior Scales, 2nd edition (VABS-2) parent/caregiver rating form. Our results show that the three ELS measures were significantly correlated with multiple measures from the VABS-2 when controlling for age. Several correlations remained significant even when nonverbal cognitive ability was included as a control variable. Our results suggest that expressive language skills contribute to adaptive behavior in children, adolescents, and young adults with DS regardless of age and some of these associations are not explained solely by overall cognitive delays. Further studies including longitudinal data are needed to extend our results.
Association between postoperative acute kidney injury and mortality after plastic and reconstructive surgery
Authors: Sung Ha Min , Oh Ah Ran , Jung Minsu , Kim Hara , Lee Sooyeon , Cha Dahye , Park Jungchan
Published: November 2022

Acute kidney injury (AKI) is a common postoperative disorder that is associated with considerable morbidity and mortality. Although the role of AKI as an independent risk factor for mortality has been well characterized in major surgeries, its effect on postoperative outcomes in plastic and reconstructive surgery has not been evaluated. This study explored the association between postoperative AKI and mortality in patients undergoing plastic and reconstructive surgery. Consecutive adult patients who underwent plastic and reconstructive surgery without end-stage renal disease (n = 7059) at our institution from January 2011 to July 2019 were identified. The patients were divided into two groups according to occurrence of postoperative AKI: 7000 patients (99.2%) in the no AKI group and 59 patients (0.8%) in the AKI group. The primary outcome was mortality during the first year, and overall mortality and 30-days mortality were also compared. After inverse probability weighting, mortality during the first year after plastic and reconstructive surgery was significantly increased in the AKI group (1.9% vs. 18.6%; hazard ratio, 6.69; 95% confidence interval, 2.65–16.85; p < 0.001). In this study, overall and 30-day mortalities were shown to be higher in the AKI group, and further studies are needed on postoperative AKI in plastic and reconstructive surgery.
Plasma proteomic profiling in postural orthostatic tachycardia syndrome (POTS) reveals new disease pathways
Authors: Johansson Madeleine , Yan Hong , Welinder Charlotte , Végvári Ákos , Hamrefors Viktor , Bäck Magnus , Sutton Richard , Fedorowski Artur
Published: November 2022

Postural orthostatic tachycardia syndrome (POTS) is a cardiovascular autonomic disorder characterized by excessive heart rate increase on standing, leading to debilitating symptoms with limited therapeutic possibilities. Proteomics is a large-scale study of proteins that enables a systematic unbiased view on disease and health, allowing stratification of patients based on their protein background. The aim of the present study was to determine plasma protein biomarkers of POTS and to reveal proteomic pathways differentially regulated in POTS. We performed an age- and sex-matched, case–control study in 130 individuals (case–control ratio 1:1) including POTS and healthy controls. Mean age in POTS was 30 ± 9.8 years (84.6% women) versus controls 31 ± 9.8 years (80.0% women). We analyzed plasma proteins using data-independent acquisition (DIA) mass spectrometry. Pathway analysis of significantly differently expressed proteins was executed using a cutoff log2 fold change set to 1.2 and false discovery rate (p-value) of < 0.05. A total of 393 differential plasma proteins were identified. Label-free quantification of DIA-data identified 30 differentially expressed proteins in POTS compared with healthy controls. Pathway analysis identified the strongest network interactions particularly for proteins involved in thrombogenicity and enhanced platelet activity, but also inflammation, cardiac contractility and hypertrophy, and increased adrenergic activity. Our observations generated by the first use a label-free unbiased quantification reveal the proteomic footprint of POTS in terms of a hypercoagulable state, proinflammatory state, enhanced cardiac contractility and hypertrophy, skeletal muscle expression, and adrenergic activity. These findings support the hypothesis that POTS may be an autoimmune, inflammatory and hyperadrenergic disorder.
Tumor microenvironment-activated multi-functional nanodrug with size-enlargement for enhanced cancer phototheranostics
Authors: Chen Hongtao , Zhou Bingcheng , Zheng Xian , Wei Jie , Ji Chendong , Yin Meizhen
Published: November 2022

An activatable phototheranosctic nanodrug (CPMI NP) is developed which can “switch on” near-infrared fluorescence imaging and chemo-photothermal therapy functions in tumor, and exhibit significant size-enlargement for elongated tumor retention.
Bio-based monomers for amide-containing sustainable polymers
Authors: Yan Kangle , Wang Jie , Wang Zhongkai , Yuan Liang
Published: November 2022

This feature article outlines biobased monomer types and their design philosophy targeting three main polymerization routes towards achieving sustainable polymers with amide groups.
Topoisomers and aromaticity of a redox active 50π core-modified isophlorinoid
Authors: Udaya Hosahalli S. , Basavarajappa Ashokkumar , Gopalakrishna Tullimilli Y. , Anand Venkataramanarao G.
Published: November 2022

[50]decaphyrin displayed solvent induced conformational switching in solid state. Reversible two electron oxidation was confirmed by spectro-electrochemical measurements and the product was characterized as the largest antiaromatic dication.
In situformation of inorganic healing overlayer for interface-stabilized all-inorganic CsPbIBr2perovskite solar cells
Authors: Zhang Junshuai , Guo Qiyao , Zhao Yuanyuan , Duan Jialong , Tang Qunwei
Published: November 2022

A perovskite layer functionalized to be an outermost screen can strongly affect the capacity of the underlying device to avoid becoming decomposed under external stimuli, and subsequently affect the photovoltaic performance as well.
Structural characterization and solvent vapor sorption of two solvent-dependent Zn(ii) supramolecular architectures based on a flexible tripodal thioether-based pyridyl ligand and a dicarboxylate-based ligand
Authors: Wang Chih-Chieh , Chung Yu-Chen , Liu Chuan-Yien , Lee Gene-Hsiang , Chien Su-Ying , Chen Bo-Hao , Chuang Yu-Chun
Published: November 2022

Two solvent-dependent 3D supramolecular architectures, constructed by doubly-interpenetrating layered 2D MOF and triply-interpenetrating 3D MOF, respectively, showed interesting reversible solvent vapor ad-/desorption behaviors.
Ultra-sensitive H2S sensor based on sunflower-like In-doped ZnO with enriched oxygen vacancies
Authors: Zhang Yong-Hui , Li Ying-Ying , Yang Xuan-Yu , Gong Fei-Long , Chen Jun-Li , Xie Ke-Feng , Zhang Hao-Li , Fang Shao-Ming
Published: November 2022

In–ZnO with oxygen vacancies exhibits a higher sensing response and a shorter recovery time for H2S compared to ZnO.
On the not so anomalous water-induced structural transformations of choline chloride–urea (reline) deep eutectic system
Authors: Monteiro Hugo , Paiva Alexandre , Duarte Ana Rita C. , Galamba Nuno
Published: November 2022

A “monotonic transition” of reline, from a deep eutectic solvent to an, aqueous solution of choline chloride and urea, is portrayed by MD opposite to ND/EPSR.
Tailoring activation of CoNiO nanoparticles/porous carbon nanofibers by atomic doping for high performance supercapacitors
Authors: Sun Xiao , Liu Ying , Xu Zheng , Gao Xiaochun , Yin Xitao , Ma Xiaoguang
Published: November 2022

A CoNiO/PCNFs-2 electrode achieves 912.4 F g−1 at 1 A g−1, and the capacitance remains above 90% after 6000 cycles. The effect of Ni doping is studied by DFT calculations, which promotes the electron transfer and has a good affinity for –OH.
Wavelength dependence of the multiphoton ionization of CH3I by intense femtosecond laser pulses through Freeman resonances
Authors: Casasús Ignacio M. , Corrales María E. , Bañares Luis
Published: November 2022

Multiphoton ionization (MPI) of methyl iodide, CH3I, has been investigated with the photoelectron imaging (PEI) technique, using high intensity femtosecond laser pulses at different central wavelengths.
Theoretical study on ferroelectric nitrides with super-wurtzite structures for solar energy conversion applications
Authors: Chen Xing-Yuan , Yang Jin-Long , Chen Li-Fang , Xu Hua-Kai , Chen Jin-Man , Lai Guo-Xia , Xu Xiang-Fu , Ji Hong , Tang Jia-Jun , Zhao Yu-Jun
Published: November 2022

Mg2BiN3 is a new excellent photovoltaic candidate due to its ideal energy band, high electron mobility, high absorption coefficient and large ferroelectric polarization strength.
Wavelength-dependent photochemistry of a salicylimine derivative studied with cryogenic and ultrafast spectroscopy approaches
Authors: Artmann Kevin , Pollok Corina H. , Merten Christian , Nuernberger Patrick
Published: November 2022

The relative yield of photoproducts of N-(α-phenylethyl)salicylimine can be modulated by variation of the excitation wavelength, as we investigate by matrix-isolation IR spectroscopy with sequential irradiation and by ultrafast transient absorption.
Broadband perfect optical absorption enabled by quasi-bound states in the continuum in graphene non-concentric rings
Authors: Xu Kun , Huang Jianyuan , Wang Weihua
Published: November 2022

In this work, high performance broadband perfect THz absorption is proposed by using the bound states in the continuum in graphene non-centric rings, and the electromagnetically induced transparency (EIT) effect is also demonstrated.
Boosting the terahertz absorption spectroscopy based on the stretchable metasurface
Authors: Yan Dexian , Feng Qinyin , Yang Ji , Li Xiangjun , Zhang Le , Zhao Yang , Li Jining
Published: November 2022

A method to enhance the terahertz absorption spectrum is realized by dynamically stretching the Au-coated PDMS metamaterial.
Recent advances in reducible metal oxide catalysts for C1 reactions
Authors: Li Jialu , Peng Zhenmeng
Published: November 2022

Recent research advances of reducible metal oxide catalyst materials in important C1 reactions (CO, CO2, CH4) are reviewed, with discussions on remaining challenges and future research directions in this field.
Determination of accessibility and spatial distribution of chiral Rh diene complexes immobilized on SBA-15 via phosphine-based solid-state NMR probe molecules
Authors: Rieg Carolin , Kirchhof Manuel , Gugeler Katrin , Beurer Ann-Katrin , Stein Lukas , Dirnberger Klaus , Frey Wolfgang , Bruckner Johanna R. , Traa Yvonne , Kästner Johannes , Ludwigs Sabine , Laschat Sabine , Dyballa Michael
Published: November 2022

We reveal a method to quantify accessibility and location of molecular catalysts, immobilized on SBA-15 and applied in 1,2-additions.
Laboratory-scale X-ray absorption spectroscopy of 3d transition metals in inorganic thin films
Authors: Kallio Antti-Jussi , Weiß Alexander , Bes Rene , Heikkilä Mikko J. , Ritala Mikko , Kemell Marianna , Huotari Simo
Published: November 2022

Ex-situ and in-situ x-ray absorption near edge spectroscopy (XANES) and ex-situ extended x-ray absorption fine structure (EXAFS) studies of CuI and CuO thin films with laboratory-scale X-ray absorption spectrometer in fluorescence mode.
Real-time measurements of product compounds formed through the reaction of ozone with breath exhaled VOCs
Authors: Xu Xin , Pang Hongwei , Liu Chao , Wang Kangyi , Loisel Gwendal , Li Lei , Gligorovski Sasho , Li Xue
Published: November 2022

Human presence can affect indoor air quality because of secondary organic compounds formed upon reactions between gaseous oxidant species, e.g., ozone (O3), hydroxyl radicals (OH), and chemical compounds from skin, exhaled breath, hair and clothes.
Environmental evaluation of carbon dot and fullerene formation in atmospheric particulate matter (PM10): observations from their free radical scavenging and electrochemical studies
Authors: Islam Nazrul , Bora Mousumi , Saikia Monikankana , Boruah Anusuya , Roy Kallol , Konwar Rituraj , Saikia Binoy K.
Published: November 2022

Human exposure to atmospheric particulate matter (PM) is of great interest owing to its carbonaceous nature with potential health impact.
Efficient mercury removal in 30 seconds by designing a dithiocarbamate-based organic polymer with customizable functionalities and tunable properties
Authors: Thurakkal Liya , Porel Mintu
Published: November 2022

A novel class of organic polymer (OP) with customizable functional groups in the backbone and side-chain was designed and synthesized to remove toxic Hg2+ ions from contaminated water within 30 seconds using a simple spin column technique.
l-Theanine alleviates heat stress-induced impairment of immune function by regulating the p38 MAPK signalling pathway in mice
Authors: Hu Yuan , Lin Ling , Liu Kehong , Liu Enshuo , Han Shumin , Gong Zhihua , Xiao Wenjun
Published: November 2022

L-Theanine can regulate the immune system's function and inflammatory responses under heat stress via activation of the p38 MAPK signalling pathway.
Synergy of metallic Pt and oxygen vacancy sites in Pt–WO3−xcatalysts for efficiently promoting vanillin hydrodeoxygenation to methylcyclohexane
Authors: Sun Mengya , Zhang Yanfei , Liu Wang , Zhao Xinpeng , Luo Hu , Miao Gai , Wang Zhiqiang , Li Shenggang , Kong Lingzhao
Published: November 2022

Pt–WO3−xcatalysts with more Pt0species and proximity of oxygen vacancy active sites derived from WO3−x, assisted by the hydrogen spillover effect, lead to an excellent methylcyclohexane yield (92.5%) at 220 °C, under 4.0 MPa H2inn-hexane solvent.
Design of a piezo-photocatalytic system using both fluid and visible light as driving energy
Authors: Liu Jinrui , Xie Zhuojiong , Lin Jingyuan , Liu Ziming , Su Qihang , Peng Fengping
Published: November 2022

The flow-driven piezo-catalysis has been enhanced under visible light due to injection of hot electrons.
Correction: Dearomative logic in natural product total synthesis
Authors: Huck Christopher J. , Boyko Yaroslav D. , Sarlah David
Published: November 2022

Correction for ‘Dearomative logic in natural product total synthesis’ by Christopher J. Huck et al., Nat. Prod. Rep., 2022, https://doi.org/10.1039/d2np00042c.
Spodium bonding to anticrown-Hg3boosts phosphorescence of cyclometalated-PtIIcomplexes
Authors: Rozhkov Anton V. , Katlenok Eugene A. , Zhmykhova Margarita V. , Kuznetsov Maxim L. , Khrustalev Victor N. , Tugashov Kirill I. , Bokach Nadezhda A. , Kukushkin Vadim Yu.
Published: November 2022

Noncovalent spodium bonding boosts the phosphorescence of platinum emitters.
New members of radical bridged Ln2metallocene single-molecule magnets based on the unsubstituted 1,2,4,5-tetrazine ligand
Authors: Mavragani Niki , Kitos Alexandros A. , Mansikkamäki Akseli , Murugesu Muralee
Published: November 2022

The combination of the 1,2,4,5-tetrazine (tz) with Ln metallocenes led to a new family of radical-bridged dinuclear complexes. Strong magnetic Ln–rad coupling was observed, which afforded zero-field SMM behavior for the Tb and Dy analogues.
How do layered double hydroxides evolve? Firstin situinsights into their synthesis processes
Authors: Doungmo G. , Morais A. F. , Mustafa D. , Kamgaing T. , Njanja E. , Etter M. , Tonlé I. K. , Terraschke H.
Published: November 2022

In situcharacterisation techniques granted unprecedented experimental access to the formation dynamics of carbonate-intercalated Mg2+/Al3+LDHs.
Investigating electrochemical deposition of gold on commercial off-the-shelf 3-D printing materials towards developing sensing applications
Authors: Partanen Kristin , Pei Yu , Hillen Phillip , Hassan Malek , McEleney Kevin , Schatte Gabriele , Payne Sarah Jane , Oleschuk Richard , She Zhe
Published: November 2022

Customized electrodes were made with 3-D printing and gold electrochemical reduction towards analytical applications.
Luminescence, energy transfer, colour modulation and up-conversion mechanisms of Yb3+, Tm3+ and Ho3+ co-doped Y6MoO12
Authors: Guo Peng , Wang Jiaxuan , Liao Chuan , Zhou Haifeng , Huang Dapeng , Zhou Guangjun , Yu Xiaoqiang , Hu Jifan
Published: November 2022

Up-conversion materials based on YMO were successfully synthesized by the sol–gel method, and the luminescence colour tuning was achieved by changing the type and concentration of dopant ions (Tm3+, Ho3+).
Improving natural products identification through molecular features-oriented precursor ion selection and targeted MS/MS analysis: a case study of Zhi-Ke-Yang-Yin capsule
Authors: Wang Hongping , Yin Qiong , Wang ZiJian , Peng Ping , Fan Chunlan , Zhang Run , Zhao Chen , Lin Zhaozhou
Published: November 2022

Chemical substance identification is an indispensable step in research on therapeutic materials based on traditional Chinese medicine and its formulas.
Ab initio insight into the electrolysis of water on basal and edge (fullerene C20) surfaces of 4 Å single-walled carbon nanotubes
Authors: Jiang Zhen , Intan Nadia N. , Yang Qiong
Published: November 2022

The extreme surface reactivity of 4 Å single-walled carbon nanotubes (SWCNTs) makes for a very promising catalytic material for electrochemical oxygen evolution reactions.
Design, synthesis, and biological evaluation of novel bioactive thalidomide analogs as anticancer immunomodulatory agents
Authors: Kotb Anas Ramadan , Bakhotmah Dina A. , Abdallah Abdallah E. , Elkady Hazem , Taghour Mohammed S. , Eissa Ibrahim. H. , El-Zahabi Mohamed Ayman
Published: November 2022

Cancer is still a dangerous disease with a high mortality rate all over the world.
Heterometallic palladium–iron metal–organic framework as a highly active catalyst for cross-coupling reactions
Authors: Miguel-Casañ Eugenia , Darawsheh Mohanad D. , Fariña-Torres Víctor , Vitórica-Yrezábal Iñigo J. , Andres-Garcia Eduardo , Fañanás-Mastral Martín , Mínguez Espallargas Guillermo
Published: November 2022

Palladium-based metal–organic frameworks (Pd-MOFs) are an emerging class of heterogeneous catalysts extremely challenging to achieve due to the facile leaching of palladium and its tendency to be reduced.
A novel distance‐based system reactive power index for system‐level reactive power reserve assessment
Authors: Rizvi Syed Muhammad Hur
Published: November 2022

Voltage stability of the power system is of major concern with ever‐increasing stress in the transmission network. The availability of ample reactive power reserve is essential to ensure voltage stability of the power system. Voltage stability and status of reactive power reserves can be monitored in real‐time by using synchrophasor measurements at a very fast reporting rate. Although much attention has been given to online voltage stability monitoring, there has been less focus on real‐time monitoring of reactive power reserve status. In this regard, the major contributions of the study are: (i) development of a novel distance‐based generalised approach for the computation of the system reactive power index, (ii) a proactive methodology for identification and impact estimation of the nearest Q‐limit breach and (iii) formulation of an optimisation problem to identify the limited number of critical generators that need PMUs for accurately predicting the value of the proposed index. The proposed scheme looks at the reactive power reserve of the generators in the network as numerical features. The istance between the base case and nose point numerical features is computed offline. The distance between the current operating point and nose point numerical features can be computed in an online manner. The ratio of these two distance measures is proposed as a system reactive power index. Moreover, a methodology to predict the post‐Q limit breach value of the index is also introduced. The proposed approach can be used with PMUs, linear state estimators or traditional SCADA measurements. Case studies for IEEE 57 and 118 bus test systems are presented to validate the performance of the proposed index.
Characterization and dynamics of the peculiar stream Jhelum
Authors: Woudenberg Hanneke C. , Koop Orlin , Balbinot Eduardo , Helmi Amina
Published: November 2022

Context. Stellar streams are a promising tool to study the Milky Way’s dark matter subhalo population, as interactions with subhalos are expected to leave visible imprints in the streams in the form of substructure. However, there may be other causes of substructure.

Aims. Here we studied the kinematics and the unusual morphology of the stellar stream Jhelum.

Methods. Using a combination of ground-based photometry and Gaia EDR3 astrometry, we characterized the morphology of Jhelum. We combined this new data with radial velocities from the literature to perform orbit integrations of the stream in static Galactic potentials. We also carried out N-body simulations in the presence of the Sagittarius dwarf galaxy.

Results. The new data reveal a previously unreported tertiary component in the stream, as well as several gaps and a kink-like feature in its narrow component. We find that for a range of realistic Galactic potentials, no single orbit is able to reproduce Jhelum’s radial velocity data entirely. A generic property of the orbital solutions is that they share a similar orbital plane to Sagittarius and this leads to repeated encounters with the stream. Using N-body simulations that include a massive Sagittarius, we explored its effect on Jhelum, and we show that these encounters are able to qualitatively reproduce the narrow and broad components in Jhelum, as well as create a tertiary component in some cases. We also find evidence that such encounters can result in an apparent increase in the velocity dispersion of the stream by a factor up to four due to overlapping narrow and broad components.

Conclusions. Our findings suggest that the Jhelum stream is even more complex than once thought; however, its morphology and kinematics can tentatively be explained via the interactions with Sagittarius. In this scenario, the formation of Jhelum’s narrow and broad components occurs naturally, yet some of the smaller gap-like features remain to be explained.
Remote sensing quantitative monitoring of chlorophyll a concentration in Taihu Lake based on measured spectrum of water surface
Authors: Lu Liufeige
Published: November 2022

In order to solve the regional and seasonal limitations of the algorithm, the database is introduced into the chlorophyll a concentration inversion. Usually, the inherent optical quantity of different water bodies in different seasons is obtained through a large number of field experiments and laboratory analysis, and stored in the database, and the index is established according to water body, season and inherent optical quantity. The main content of this paper is to quantitatively monitor the concentration, distribution and evolution of chlorophyll a in turbid and eutrophic water bodies such as Taihu Lake by remote sensing. The research of inversion method and strategy based on measured spectrum of water surface provides theoretical and methodological support for its application in remote sensing images. The data obtained in this paper mainly include: water quality parameters, apparent optical quantity and inherent optical quantity of Taihu Lake. The results show that the correlation coefficient R2=0.936, which is linear and sensitive to high-value areas. This result not only reflects the feasibility of the ratio index model for chlorophyll content inversion, but also shows that the absolute error is basically below 23 mg/m3, and the inversion result is relatively stable.
Immune, metabolism and therapeutic targets in RA (Rheumatoid Arthritis)
Authors: Liu Keying
Published: November 2022

Rheumatoid arthritis is a classic autoimmune disease, the pathogenesis of which is closely linked to the auto-reactivity of immune cells and joint inflammation. Three cell types, namely T cells, macrophages and fibroblast-like synoviocytes (FLS), play an important role in the pathogenesis of RA. Numerous studies have pointed to a metabolic reprogramming of T cells, macrophages and FLS in the pathogenesis of RA arthritis, with alterations in different metabolic pathways of cells, mainly producing a shift from oxidative phosphorylation (OXPHOS) to glycolysis, in addition to lipid metabolism and amino acid metabolism which are also altered in the cellular activation state. Metabolic changes are regulated by metabolism-related signalling pathways, and RA is associated with two representative signalling pathways, namely the mTOR signalling pathway and the AMPK signalling pathway. In RA, both signalling pathways are activated or inhibited, and through a series of cascade reactions, different gene expressions are ultimately induced, altering intracellular metabolic pathways and promoting pro-inflammatory functions (e.g. pro-inflammatory cytokine release and FLS phenotypes), or inhibiting the expression of genes related to immune tolerance. Targeting key components of metabolic signalling pathways and key enzymes in cellular metabolic pathways in RA has emerged as a new way of finding drugs for RA, and many modulators targeting these targets have been extensively studied for their therapeutic effects in RA. In this article, we focus on cellular metabolic alterations in RA, related signalling pathways and possible drugs targeting RA metabolic pathways.
Mitochondrial proteins that connected with calcium: do their pathways changes in PAH?
Authors: Zhang Ruobing
Published: November 2022

Calcium can be regulated by mitochondria and also plays a significant role in mitochondrial pathways. Recent study showed mitochondrial protein changes in the right ventricle in pulmonary arterial hypertension, which affects calcium network at the same time. The specific objective of this study is to assess the pathway of calcium transport by permeable pore in mitochondria and investigate the regulation of mitochondrial proteins in order to find the connection between mitochondrial proteins and right ventricular dysfunction in PAH (pulmonary arterial hypertension). This literature-based review came out by searching articles in Pubmed and Science Direct. And the related flow chart is expressed by the form of PRISMA. There is a network between mitochondria and calcium through the transport chain called mitochondria permeability transition pore (MPTP) as well as different kinds of proteins that are located in the mitochondria. MPTP is a kind of mitochondria pore and can have conformational changes after protein phosphorylation or reaction between mitochondrial proteins to activate the apoptosis capase cascade process in cell death. In addition, MPTP can be activated by other mitochondrial protein like signal transducer activator of transcription3 (STAT3) to activate cytochrome c in pro-apoptosis to initiate cell death at the same time. The most obvious finding from this study is the role of calcium regulation in therapeutic treatment in PAH patients, which suggest an imaginable role for calcium transporter like mitochondria calcium uniporter (MCU) promoting bio-markers in cardiovascular disease resulting from mitochondrial dysfunction. In addition, right ventricle is a target of PAH in which mitochondria in RV would play an essential role in pathways such as ATP production via mitochondria metabolism.
Progress on common thyroid diseases and systemic immune inflammation index
Authors: Tan Hong , Ye Qing
Published: November 2022

Thyroid disease belongs to the endocrine system disease, which is relatively common in clinical practice, mainly including hyperthyroidism, thyroiditis, thyroid nodules, hypothyroidism and so on. Thyroid tumor is a relatively common clinical endocrine and head and neck tumor, among which the most common malignant tumor is differentiated thyroid cancer (differentiated thyroid carcinoma, DTC), with a high incidence rate, good prognosis, and common cervical lymph node metastasis or distant metastasis. This article mainly provides a simple overview of the concept of systemic immune inflammation index, and makes an indepth analysis of the relationship between inflammation and disease pathogenesis and systemic immune inflammation index and thyroid disease, in order to provide a theoretical reference for clinical and related personnel.
Near-infrared Two-region AIE Nanoprobe Study for AD Diagnosis and Treatment Integration
Authors: Li Yaqi , Chen Mengyao
Published: November 2022

In this paper, we address the lack of specific targeting of β-amyloid β-protein (Aβ) in the current Alzheimer's disease (AD) diagnosis and treatment, and build a novel AIE nanoprobe molecule based on molecular design and nano-self-assembly technology. Based on the molecular design and nano-self-assembly technology, a new two-component AIE nanoprobe molecule with integrated AD diagnosis and treatment was constructed by co-assembling two-component AIE components. The NIR AIE nanomolecule can effectively penetrate the blood brain barrier (BBB) and depolymerize Aβ fibers, alleviate reactive oxygen species (ROS) in the focal area, and achieve highly sensitive imaging and specific depolymerization.
Research progress on VARROA DESTRUCTOR
Authors: Chen Yuxin
Published: November 2022

Varroa destructor is the most serious threat for western honeybees worldwide. It parasitizes mostly on honeybee's pupae and larvae, resulting in impaired development, decreased immunity, residual wings, loss of flight ability, and even direct death. At the same time, it can cause a series of diseases, greatly infesting bee colonies. This paper introduces the classification, distribution and biological characteristics of Varroa destructor, and discusses its transmission mode, harm form and common control measures.
Determination of Taurine in Quadriceps Femoris by High Performance Liquid Chromatography with Precolumn Derivatization
Authors: Fan Jingjing , Lan Bohua , Yu Jia , Wang Junge , Ning Ke , Wang Fang , Liu Huilian
Published: November 2022

A method for determination of taurine in mouse quadriceps femoris by high performance liquid chromatography with precolumn derivatization ophthalaldehyde (OPA) was established. The sample was extracted and treated with canon exchange resin. Results showed that taurine in quadriceps femoris was separated and quantified on C18 reversed phase column by high performance liquid chromatographic (HPLC) after derivatization with OPA in 3min, using mixture of methanol and phosphate （V/V＝1:1，pH＝4.9） as mobile phase, rate of flow is 0.6mL/min, detecting at 340nm by UV-detector, L-Glutamine as internal standard. The result showed that the linear ranger of taurine was 6.25-187.7ng/mL, correlation coefficient R2=0.9994, the recoveries were 91.8%-101.8%, RSD=3.2% (n=6). The retention time of taurine is 7.32 min. The concentration of taurine in mouse quadriceps femoris is 3.18mg/g. The protein and amino acid were separated by sample pre-treatment. The method is of good separation effect, simple, reliable, and can be used to analyze the taurine concentration in mammal tissue.
Beta decay studies and search for octupole deformation in the A ∼ 225 Po-Fr nuclei
Authors: Polettini M.
Published: November 2022

In the landscape of nuclear shapes, dominated by reflection-symmetric forms leading to either spherical or axially deformed arrangements, the occurrence of asymmetric pear-like nuclei has long been searched for. Evidence for static octupole deformation has only been found in selective areas of the nuclear chart, in the mass regions A ∼ 222 and A ∼ 146, the so-called “Islands of Octupole Deformation” (IOD). This paper is focused on β decay studies in the Po-Fr nuclei in the 220 ≤ A ≤ 230 island of octupole deformation exploiting the FRS+DESPEC setup at GSI in Spring 2021. The experimental setup and the analysis techniques employed to perform this study are here shown and discussed, together with preliminary results from the on-going analysis.
Exploitation of energy geo-resources and their impacts on the environment
Authors: Battimelli Elvira
Published: November 2022

The increase of the world population has led to a major demand for energy with a consequent huge exploitation of natural fossil resources. To build a sustainable future and reach the goals of the green economy, it is necessary to gradually use low-carbon energies taking into account the possible risks associated with each type of energy production. A much-debated incidental event is the anthropogenic or induced seismicity connected with the exploitation of energy geo-resources. It arises because of changes in the pore pressure of subsurface rocks that, in turn, create increased stress that can exceed the threshold value for fracture. This situation may verify from underground extraction or injection of fluids, geothermal energy production, storage of CO2, natural gas, or hydrogen in underground cavities. The interest of the scientific community, politics and society towards this issue has grown in the last decade especially after the wide use of the fracking technique in the United States and the occurrence of the 2012 Emilia Romagna earthquake (Italy). Both conventional and unconventional geo-resources exploitation techniques can induce seismicity causing damage to the industrial plant itself and the surrounding buildings especially in highly urbanized areas and in extreme situations even generate loss of life. It is, therefore, necessary to carry out detailed studies of seismicity occurred in areas of geo-resources exploitation to expand knowledge of this phenomenon and develop safety protocols to prevent and mitigate the risks.
Effect of C and Si contents on microstructure and impact toughness in CGHAZ of offshore engineering steel
Authors: Liu Dekun , Yang Jian , Zhang Yinhui , Li Rongbin
Published: November 2022

The combined effect of the C and Si contents on the microstructure and low-temperature impact toughness of heat-affected zone (HAZ) of the offshore engineering steel. As the C and Si content is decreased from 0.09 to 0.07 wt.% and 0.12 to 0.03 wt.%, the HAZ toughness at −40 °C is increased from 36 to 180 J, and the hardness in the coarse-grained heat-affected zone (CGHAZ) is decreased from 325 to 297 HV0.05. The higher C and Si content promote the precipitation of M23C6 and cementite, but restrain the formation of MC and M2C carbide in the present developed steels. The microstructures in the CGHAZ are comprised of a mixture of martensite and bainite after the welding with the heat input of 50 kJ/cm and are similar with the different C and Si contents. As the C and Si contents are decreased, the density of the geometrically necessary dislocation (GND) is increased. The fracture is changed from brittle to ductile manner, and the cleavage facet size is decreased from 23 to 11 µm. Reducing the C and Si contents significantly decreases the packet size from 25 to 17 µm, thereby leading to the improvement of HAZ toughness.
Friction and wear properties of high manganese steel liner under different physical conditions
Authors: Zhao Guanghui , Zhang Zhe , Li Juan , Li Huaying , Zhang Yishuai
Published: November 2022

In this paper, high manganese steel with cone crushing motor cone lining plate is selected, and the sliding friction and wear experiments of 50 N, 100 N and 150 N loads were carried out in different media environments (dry friction, deionized water solution, 3.5 wt.% NaCl solution) by using Rtec-MFT 5000 tester. The wear mechanism was studied by the data collected by friction and wear experiments and the morphology analysis of the microstructure by scanning electron microscopy (SEM). The results showed that the friction coefficient of high manganese steel was the maximum in dry friction condition, and the minimum in deionized water solution. Under the same load, the wear volume in 3.5 wt.% NaCl solution was always the largest, followed by the dry friction in deionized aqueous solution. This was because the overall wear was accelerated after adding water, especially with ionic solutions containing salts, the double damage of electrochemical corrosion and physical wear would occur, resulting in more serious wear. According to the pictures of the surface microstructure, it was found that the microstructure damage of the high manganese steel sample in 3.5% NaCl solution was the most serious, and the damage was the least in deionized aqueous solution. In conclusion, the high manganese steel material had the best wear resistance in deionized aqueous solution, followed by dry friction, and the worst wear resistance in 3.5 wt.% NaCl solution.
Nonlinear crystals for frequency conversion
Authors: Segonds Patricia , Boulanger Benoit , Schunemann Peter
Published: November 2022

Crystals can convert wavelengths emitted by lasers using a second-order process. They allow light to be generated with smaller or higher wavelengths than those of the input beam. The issue is to select the nonlinear crystal having the best conversion efficiency at the targeted wavelengths, which requires a high non-linearity and suited transparency range as well as phase-matching conditions.
When malignancy hits twice – synchronous gastric carcinoma and non-Hodgkin-B-cell lymphoma in a patient with common variable immunodeficiency
Authors: Krick David , Hauptmann Kathrin , Penndorf Volker , Tacke Frank , Krüger Renate , von Bernuth Horst , Sigal Michael
Published: November 2022

Patients with common variable immunodeficiency (CVID) generally bear a higher risk of non Hodgkin B-cell lymphomas and solid tumors, in particular gastric adenocarcinoma.

Here we report a case of a 58-year-old male CVID patient who developed both malignancies within a very short period, as documented by two subsequent esophagogastroduodenoscopies performed within 4 months. While the first upper gastrointestinal endoscopy for routine surveillance purposes was uneventful, the second one after developing unexplained weight loss revealed two new neoplastic lesions in the stomach. The histological evaluation revealed a poorly differentiated adenocarcinoma infiltrating the muscularis propria forcing gastrectomy as well as a high-grade B-non-Hodgkin-lymphoma with detection of a MYC- and BCL6-translocation, necessitating chemotherapy with R-CHOP.

This case emphasizes the necessity of high awareness for gastric neoplasia in patients with CVID and highlights the need of a standardized yet not established endoscopic surveillance protocol for this vulnerable group.
„Hyposplenie“, eine weitgehend unerkannte Immunschwäche: Ist die Sonografie hilfreich?
Authors: Alhyari Amjad , Geisler Lisa , Eilsberger Friederike , Dietrich Christoph F. , Findeisen Hajo , Trenker Corinna , Görg Christian , Safai Zadeh Ehsan
Published: November 2022

Das Immundefizienzsyndrom der funktionellen Hyposplenie/Asplenie ist weitgehend unerkannt.
Die Goldstandardprozedur stellt die Technetium-99m-Szintigrafie von hitzedenaturierten
Erythrozyten (TSZ) sowie der Nachweis von pitted Erythrozyten oder Howell-Jolly-Körperchen
(HJB) dar. Erste Arbeiten weisen darauf hin, dass dieses Krankheitsbild mit einer kleinen Milz
assoziiert ist. Ziel der vorliegenden Übersicht ist es, den Stellenwert der B-Bild-Sonografie
und der kontrastunterstützten Sonografie bei der Immunschwäche der Hyposplenie
darzustellen.
Minimally Invasive Approaches to DIEP flap Harvest: A review of
current data
Authors: Nores Gabriela del Pilar Garcia , Kanchwala Suhail
Published: November 2022

Breast cancer is the most prevalent cancer in the female population. Autologous
tissue is often used for reconstruction after mastectomy. The deep inferior
epigastric (DIEP) flap is a favorite for breast reconstruction because it
entails careful perforator dissection with less muscle destruction. Recently,
minimally invasive techniques in DIEP flap harvest have increased in popularity
but their complication rate and security profile may vary from one technique to
another. The purpose of this review study is to evaluate and compare two
minimally invasive surgical approaches to abdominal based free flap harvest: the
transabdominal pre-peritoneal robotic assisted DIEP flap harvest and total
extra-peritoneal laparoscopic DIEP flap harvest.
Warum der Wittenberger Anatom und Wissenschaftler Konrad Victor Schneider (1614–1680) auch für die Pneumologen bedeutsam ist
Authors: Koehler Ulrich , Korbmacher-Steiner Heike , Seifert Dietmar
Published: November 2022

Der Wittenberger Arzt Konrad Victor Schneider (1614–1680) hat als Erster den Nachweis erbracht, dass Schleim nicht im Gehirn gebildet und auch nicht über das Siebbein in die Nasenhöhle sezerniert wird. Er hat erkannt, dass es keine offene anatomische Verbindung zwischen Gehirn und nasalem Luftraum gibt. Schneider hat die sinunasale Schleimhaut als Produktionsstätte des Schleims entdeckt und damit die Hypothese der zerebralen Schleimproduktion und -sekretion von Hippokrates, Galen und Vesal widerlegt. Zu Ehren von Schneider wurde die Schleimhaut „membrana Schneideria“ benannt.
A Concise Total Synthesis of (±)-Stepharine and (±)-Pronuciferine
Authors: Chen Ruiming , Jia Shihu , Cheng Hong-Gang , Zhou Qianghui , Man Yuning
Published: November 2022

A concise total synthesis of (±)-stepharine and (±)-pronuciferine using readily available reagents as the starting materials is reported. This synthesis features a three-component Catellani reaction/Au-catalyzed 6-exo-dig cyclization for the assembly of 1-methylene-tetrahydroisoquinoline scaffold and an oxidative dearomatization for constructing spiro-cyclohexadienone scaffold.
Planes for Perforator/Skin Flap Elevation—Definition, Classification, and Techniques
Authors: Kwon Jin Geun , Brown Erin , Suh Hyunsuk Peter , Pak Changsik John , Hong Joon Pio
Published: November 2022

Background Elevation in different layers achieving thin flaps are becoming relatively common practice for perforator flaps. Although postreconstruction debulking achieves pleasing aesthetic results and is widely practiced, customized approach during elevation to achieve the ideal thickness will increase efficiency while achieving the best possible aesthetic outcome. Multiple planes for elevation have been reported along with different techniques but it is quite confusing and may lack correspondence to the innate anatomy of the skin and subcutaneous tissue.

Methods This article reviews the different planes of elevation and aims to clarify the definition and classification in accordance to anatomy and present the pros and cons of elevation based on the different layers and provide technical tips for elevation.

Results Five different planes of elevation for perforator flaps are identified: subfascial, suprafacial, superthin, ultrathin, and subdermal (pure skin) layers based on experience, literature, and anatomy.

Conclusion These planes all have their unique properties and challenges. Understanding the benefits and limits along with the technical aspect will allow the surgeon to better apply the perforator flaps.
Mechanistic and Synthetic Studies of Biaryl Birch Reductions
Authors: Koide Kazunori
Published: November 2022

The Birch reduction of biaryls generally converts one of the two arenes into a cyclohexa-1,4-diene. Biaryls are more reactive than monocyclic arenes under the Birch conditions. Unlike the reduction of monocyclic arenes, biaryl reduction proceeds through two consecutive electron transfer steps before the protonation of the dianion intermediate. The biaryl reductions and subsequent alkylations in one pot rapidly increase the molecular complexity and thus have been used in the synthesis of natural products and drug-like molecules.

1 Introduction

2 The Physical Organic Chemistry of the Birch Reduction of Biaryls

3 Biaryls as the Mediators of Electron Transfer

4 Methods for the Dissolving-Metal Reduction of Biaryls

5 Intercepting the Biaryl Reduction Intermediates with Electrophiles

6 Synthetic Applications of the Dissolving-Metal-Mediated Reductions of Biaryls

7 Outlook