bluuebunny/crossref_metadata_2025 huggingface dataset:
Case report: Medical cannabis—warfarin drug-drug interaction
Authors: Thomas Tyan F. , Metaxas Evdokia S. , Nguyen Thu , Bennett Whitni , Skiendzielewski Kathryn V. , Quinn Diane H. , Scaletta Alice L.
Published: January 2022

Aim

A case of an 85-year-old patient with concurrent use of warfarin and medical cannabis containing delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) is described. Warfarin continues to be a cornerstone of anticoagulation treatment despite the recent addition of FDA-approved anticoagulant agents. It is well known that warfarin has numerous drug interactions; however, much remains unknown about its interaction with THC and CBD. A literature review was conducted to identify documented cases of possible interactions between cannabis and warfarin. The case reports we identified noted that cannabis may potentially increase warfarin’s effect. Therefore, we aimed to determine why an effect was not seen on our patient’s warfarin dose despite daily use of medical cannabis.

Case

This case report describes an 85-year-old patient who despite starting an oromucosal medical cannabis regimen of THC and CBD (which provided 0.3 mg of THC and 5.3 mg CBD once daily and an additional 0.625 mg of THC and 0.625 mg CBD once daily as needed) had minimal INR fluctuations from October 2018 to September 2019.

Conclusion

Despite the introduction and use of medical cannabis therapy, with both THC and CBD components, an elderly patient with concurrent warfarin use did not see major INR fluctuations, in contrast to published literature. The potential for warfarin and THC/CBD interactions may be dependent on route of administration and dose of the cannabis product.
Consistent changes in the intestinal microbiota of Atlantic salmon fed insect meal diets
Authors: Li Yanxian , Gajardo Karina , Jaramillo-Torres Alexander , Kortner Trond M. , Krogdahl Åshild
Published: January 2022

Background

Being part of fish's natural diets, insects have become a practical alternative feed ingredient for aquaculture. While nutritional values of insects have been extensively studied in various fish species, their impact on the fish microbiota remains to be fully explored. In an 8-week freshwater feeding trial, Atlantic salmon (Salmo salar) were fed either a commercially relevant reference diet or an insect meal diet wherein black soldier fly (Hermetia illucens) larvae meal comprised 60% of total ingredients. Microbiota of digesta and mucosa origin from the proximal and distal intestine were collected and profiled along with feed and water samples.

Results

The insect meal diet markedly modulated the salmon intestinal microbiota. Salmon fed the insect meal diet showed similar or lower alpha-diversity indices in the digesta but higher alpha-diversity indices in the mucosa. A group of bacterial genera, dominated by members of theBacillaceaefamily, was enriched in salmon fed the insect meal diet, which confirms our previous findings in a seawater feeding trial. We also found that microbiota in the intestine closely resembled that of the feeds but was distinct from the water microbiota. Notably, bacterial genera associated with the diet effects were also present in the feeds.

Conclusions

We conclude that salmon fed the insect meal diets show consistent changes in the intestinal microbiota. The next challenge is to evaluate the extent to which these alterations are attributable to feed microbiota and dietary nutrients, and what these changes mean for fish physiology and health.
Sleep pattern in a group of patients undergoing hemodialysis compared to control
Authors: Hashem Reem El Sayed , Abdo Tarek Asaad , Sarhan Iman Ibrahim , Mansour Amr Mohammed
Published: January 2022

Background

Patients with chronic kidney disease progress regularly every year to end-stage renal disease and have to undergo dialysis. Sleep disturbances have been reported to be frequent among patients receiving dialysis and contributing to the increase of their mortality and morbidity. The present research aimed to study the sleep pattern in hemodialysis patients and the risk factors associated. This cross-sectional case-control study included 40 subjects divided into 2 groups: 20 cases recruited from Ain Shams University Hospital’s dialysis unit and 20 in the control group with normal Pittsburgh Sleep Quality Index score matched for age and sex. Both groups were subjected to overnight polysomnography, and the cases group was assessed by the Pittsburgh Sleep Quality Index to determine their sleep quality.

Results

Nearly all polysomnographic parameters were significantly abnormal in the cases group except for sleep onset latency (P > 0.05), showing obstructive sleep apnea and periodic limb movement (P value 0.001). Based on their Pittsburgh Sleep Quality Index score, 30% were classified as good sleepers and 70% as bad sleepers. On comparing both groups, a significant difference was found. Poor sleepers had more worse sleep efficiency (62.9%), spent longer time during their sleep in stage 1 (26.6%) with shorter REM onset latency (113.5 ± 99.5), and had a longer duration of illness with lower serum creatinine level compared to good sleepers.

Conclusions

The prevalence of obstructive sleep apnea and periodic limb movement in hemodialysis patients is high; patients with longer time on dialysis are at more risk of sleep disorders, whereas hemoglobin levels, BUN, and other demographic factors do not seem to play a role in sleep disorder. Hence, patients on hemodialysis need to be screened for sleep disorders so as to improve their mortality and morbidity.
Bronchiolitis diagnosis, treatment, and prevention in children: an evidence-based clinical practice guideline adapted for the use in Egypt based on the ‘Adapted ADAPTE’ Methodology
Authors: Abdel Baky Ashraf , Fouda Eman Mahmoud , Hussein Shahenaz Mahmoud , Sobeih Ahmad Ata , Abd Al Razek Ahmed Mohamad , Hassanain Amal Ibrahim , Galal Ashraf , Hamed Dina Houssam-Eldine , Elnady Hala Gouda , Hamdi Hala , Metwally Hoda M. Salah El Din , Hegazy Laila Abdel Ghaffar , Mohamed Magda Hassab Allah , Shaheen Malak , Saeed Maysaa Abdallah , Rashad Mohamed Mahmoud , Elattar Mona Mohsen , Refaat Nehal , Sakr Noha Mohamed Abdelsalam , Amer Osama Taha , Mansour Sameh Abdelaziz Ahmed , Tawfik Sameh , Hebish Sarah Naeem Bartella , Reda Sherif , Omar Tarek , Kamel Nevin Abdullah , Amer Yasser Sami
Published: January 2022

Background

The presented evidence-based clinical practice guideline (CPG) is proposed as a National CPG using an evidence-based and formal CPG adaptation methodology. The purpose of this study was to adapt the international CPGs’ recommendations for children with bronchiolitis to suit the healthcare system in the Egyptian context. This CPG, ‘diagnosis, treatment, and prevention of Bronchiolitis’, applies to children from 1 through 23 months of age. Other exclusions are noted. The quality of evidence, benefit-harm relationship, and strength of recommendations are indicated. This study is part of a larger collaborative initiative with the faculty staff of pediatric departments of 15 Egyptian universities and a national research center to formulate a national Committee (EPG) that aims to define the topics of, assign authors to, and assist in the adaptation of pediatric evidence-based CPGs according to a national strategic plan. The committee is guided by a formal CPG adaptation methodology: the ‘Adapted ADAPTE’.

Results

The Bronchiolitis Guideline Adaptation Group (BGAG) reviewed the results of the AGREE II assessment and decided to adapt mainly the Australasian (PREDICT) CPG and for the questions not answered in PREDICT we adapted the relevant recommendations from the American Academy of Pediatrics (AAP) CPG. Seven implementation tools were included: a care pathway for assessment of severity, a clinical algorithm for treatment of acute bronchiolitis in the emergency room, a separate flowchart for assessing babies with bronchiolitis, a power point slide presentation lecture for treatment of acute bronchiolitis, patient information in Arabic, a clinical score (Modified Tal Score) for prediction of bronchiolitis severity, and the criteria for admission and discharge in the hospital. A comprehensive set of multifaceted CPG implementation strategies was provided for the clinicians, patients, nurses, and other relevant stakeholders contextualized to the national settings

Conclusion

Our experience with this adaptation methodology provides useful insight into its utilization on a national level in Egypt. The BGAG recommended the next review of this adapted CPG to be after 3 years from its publication (i.e., 2022) after checking for updates in the original CPG.
Qualitative and quantitative strain and shear wave elastography paradigm in differentiation of breast lesions
Authors: Shehata Roaa M. A. , El-Sharkawy Mostafa A. M. , Mahmoud Omar M. , Kamel Hosam M.
Published: January 2022

Background

Breast cancer is the most common life-threatening cancer in women worldwide. A high number of women are going through biopsy procedures for characterization of breast masses every day and yet 75% of the pathological results prove these masses to be benign. Ultrasound (US) elastography is a non-invasive technique that measures tissue stiffness. It is convenient for differentiating benign from malignant breast tumors. Our study aims to evaluate the role of qualitative ultrasound elastography scoring (ES), quantitative mass strain ratio (SR), and shear wave elasticity ratio (SWER) in differentiation between benign and malignant breast lesions.

Results

Among 51 female patients with 77 histopathologically proved breast lesions, 57 breast masses were malignant and 20 were benign. All patients were examined by B-mode ultrasound then strain and shear wave elastographic examinations using ultrasound machine (Logiq E9, GE Medical Systems) with 8.5–12 MHz high-frequency probes. Our study showed that ES best cut-off point > 3 with sensitivity, specificity, PPV, NPP, accuracy was 94.7%, 85%, 94.7%, 85%, 90.9%, respectively, and AUC = 0.926 at P < 0.001, mass SR the best cut-off point > 4.6 with sensitivity, specificity, PPV, NPP, accuracy was 96.5%, 80%, 93.2%, 88.9%, 92.2%, respectively, and AUC = 0.860 at P < 0.001, SWER the best cut-off value > 4.9 with sensitivity, specificity, PPV, NPP and accuracy was 91.2%, 80%, 92.9%, 76.2%, 93.5%, respectively, and AUC = 0.890 at P < 0.001. The mean mass strain ratio for malignant lesions is 10.1 ± 3.7 SD and for solid benign lesions 4.7 ± 4.3 SD (p value 0.001). The mean shear wave elasticity ratio for malignant lesions is 10.6 ± 5.4 SD and for benign (solid and cystic) lesions 3.6 ± 4.2 SD. Using ROC curve and Youden index, the difference in diagnostic performance between ES, SR and SWER was not significant in differentiation between benign and malignant breast lesions and also was non-significant difference when comparing them with conventional US alone.

Conclusion

ES, SR, and SWER have a high diagnostic performance in differentiating malignant from benign breast lesions with no statistically significant difference between them.
Long-term scopolamine treatment altered locomotor, exploratory and anxiety-like behaviours of albino rats
Authors: Abdelghany Asmaa K. , El-Kashlan Akram M. , Emeash Hosny H. , Khalil Fatma
Published: January 2022

Background

Animal models are used to provide an adequate investigation of brain-behaviour, physiological and path physiological relationships to give insight into human behaviour and the underlying processes of drugs affecting the nervous system. Scopolamine; SCO (alkaloidl-(2)-scopolamine [l-(2)-hyoscine]) has a competitive inhibitory effect on muscarinic receptors for acetylcholine. Thus, this study was designated to investigate the effect of long-term SCO treatment on locomotor, exploratory and anxiety-like behaviours of rats using open field test.

Results

The long-term SCO treatment induced a prominent increase in locomotion (hyperactivity) and exploratory behaviour of rats. In addition, anxiety-like behavioural patterns showed a non-significant difference in SCO treated compared to control. Serotonin level was significantly decreased in the scopolamine treated group in comparison with the control group.

Conclusions

Data suggested that long-term SCO treatment resulted in marked neurobehavioural alterations in a rat as an animal model.
Hyperbolic metamaterials: fusing artificial structures to natural 2D materials
Authors: Lee Dasol , So Sunae , Hu Guangwei , Kim Minkyung , Badloe Trevon , Cho Hanlyun , Kim Jaekyung , Kim Hongyoon , Qiu Cheng-Wei , Rho Junsuk
Published: January 2022

Optical metamaterials have presented an innovative method of manipulating light. Hyperbolic metamaterials have an extremely high anisotropy with a hyperbolic dispersion relation. They are able to support high-kmodes and exhibit a high density of states which produce distinctive properties that have been exploited in various applications, such as super-resolution imaging, negative refraction, and enhanced emission control. Here, state-of-the-art hyperbolic metamaterials are reviewed, starting from the fundamental principles to applications of artificially structured hyperbolic media to suggest ways to fuse natural two-dimensional hyperbolic materials. The review concludes by indicating the current challenges and our vision for future applications of hyperbolic metamaterials.
A high accuracy modeling scheme for dynamic systems: spacecraft reaction wheel model
Authors: Abd-Elhay Abd-Elsalam R. , Murtada Wael A. , Yosof Mohamed I.
Published: January 2022

Reaction wheels are crucial actuators in spacecraft attitude control subsystem (ACS). The precise modeling of reaction wheels is of fundamental need in spacecraft ACS for design, analysis, simulation, and fault diagnosis applications. The complex nature of the reaction wheel leads to modeling difficulties utilizing the conventional modeling schemes. Additionally, the absence of reaction wheel providers’ parameters is crucial for triggering a new modeling scheme. The Radial Basis Function Neural Network (RBFNN) has an efficient architecture, alluring generalization properties, invulnerability against noise, and amazing training capabilities. This research proposes a promising modeling scheme for the spacecraft reaction wheel utilizing RBFNN and an improved variant of the Quantum Behaved Particle Swarm Optimization (QPSO). The problem of enhancing the network parameters of the RBFNN at the training phase is formed as a nonlinear constrained optimization problem. Thus, it is proposed to efficiently resolve utilizing an enhanced version of QPSO with mutation strategy (EQPSO-2M). The proposed technique is compared with the conventional QPSO algorithm and different variants of PSO algorithms. Evaluation criteria rely upon convergence speed, mean best fitness value, stability, and the number of successful runs that has been utilized to assess the proposed approach. A non-parametric test is utilized to decide the critical contrast between the results of the proposed algorithm compared with different algorithms. The simulation results demonstrated that the training of the proposed RBFNN-based reaction wheel model with enhanced parameters by EQPSO-2M algorithm furnishes a superior prediction accuracy went with effective network architecture.
Experiences of patients advising on mental health research: qualitative study in South-East European countries
Authors: Repišti Selman , Majstorović Tihana , Ramadani Fjolla , Zebić Mirjana , Novotni Ljubisha , Jovanović Nikolina
Published: January 2022

Background

Although patient and carer involvement in research is well-developed in many countries, this area has been largely overlooked in South-East European countries.

Aims

To explore experiences of patients participating in newly set up lived experience advisory panels (LEAPs) within a European Commission funded, large-scale, multi-country mental health research project that focused on improving treatment of individuals with psychosis.

Method

Twenty-one mental health patients were individually interviewed across five countries: Bosnia and Herzegovina, Kosovo, Montenegro, North Macedonia and Serbia. Topic guides covered the experience of participating in LEAPs and their sustainability. Data were analysed by framework analysis.

Results

Seven themes were identified about participating in LEAPs: predominantly positive evaluation, high levels of participant motivation, therapeutic benefits for participants, few challenges, various future perspectives, positive appraisal of the research project and mixed reflections on mental healthcare. Overall, patients’ experiences were positive and enabled them to feel empowered. Patients expressed interest in remaining involved in advisory panels. Additionally, they felt that they could potentially contribute to the work of non-government organisations.

Conclusions

This study is among the few studies exploring patient participation in research projects, and the first such study conducted in South-East European countries. Patients are highly motivated for this engagement, which has the potential to empower them to take on new social roles. Significant efforts at the national level are needed in each country, to make patient involvement in research standard practice.
Differential Alterations to the Metabolic Connectivity of the Cortical and Subcortical Regions in Rat Brain During Ketamine-Induced Unconsciousness
Authors: Chen Yali , Li Siyang , Liang Xia , Zhang Jun
Published: January 2022

BACKGROUND:

Ketamine anesthesia increased glucose metabolism in most brain regions compared to another intravenous anesthetic propofol. However, whether the changes in cerebral metabolic networks induced by ketamine share the same mechanism with propofol remains to be explored. The purpose of the present study was to identify specific features of metabolic network in rat brains during ketamine-induced subanesthesia state and anesthesia state compared to awake state.

METHODS:

We acquired fluorodeoxyglucose positron emission tomography (FDG-PET) images in 20 healthy adult Sprague-Dawley rats that were intravenously administrated saline and ketamine to achieve different conscious states: awake (normal saline), subanesthesia (30 mg kg−1 h−1), and anesthesia (160 mg kg−1 h−1). Based on the FDG-PET data, the alterations in cerebral glucose metabolism and metabolic topography were investigated by graph-theory analysis.

RESULTS:

The baseline metabolism in rat brains was found significantly increased during ketamine-induced subanesthesia and anesthesia. The graph-theory analysis manifested a reduction in metabolism connectivity and network global/local efficiency across cortical regions and an increase across subcortical regions during ketamine-induced anesthesia (nonparametric permutation test: global efficiency between awake and anesthesia, cortex: P = .016, subcortex: P = .015; global efficiency between subanesthesia and anesthesia, subcortex: P = .012).

CONCLUSIONS:

Ketamine broadly increased brain metabolism alongside decreased metabolic connectivity and network efficiency of cortex network. Modulation of these cortical metabolic networks may be a candidate mechanism underlying general anesthesia-induced loss of consciousness.
A PARTICIPAÇÃO FEMININA NO PROGRAMA MICROEMPREENDEDOR INDIVIDUAL: UMA ANÁLISE EM UM POSTO DE ATENDIMENTO SEBRAE
Authors: Azevedo Francisco Edson Coelho , Ferreira Kilvia Souza , Moreira Marcia Zabdiele , Ferreira Andre Vasconcelos
Published: January 2022

O presente trabalho objetivou caracterizar e analisar a participação feminina no Programa Microempreendedor Individual (MEI), no intuito de se traçar um perfil da mulher formalizada. Para tanto, o trabalho foi confeccionado com base em pesquisas bibliográficas e por meio da aplicação de um formulário em um Posto de Atendimento Sebrae, consultando 33 microempreendedoras. Mediante a aplicação de técnicas quanti-quali, destacam-se as seguintes conclusões do estudo: sociodemograficamente, o perfil apresentado pelas entrevistadas se alinha ao perfil traçado por outros estudos. No que se refere ao Programa MEI, o perfil aqui verificado pouco diverge do Perfil Geral do Microempreendedor, destacando-se a maior informalidade da mulher antes do registro e os benefícios previdenciários como fortes motivadores para a inscrição no referido programa. Considerando os motivos e as barreiras por elas enfrentadas, percebeu-se o desejo por independência, tendo como aspecto negativo a multiplicidade de papéis sociais: esposa, mãe e dona de um negócio.
COMUNICAÇÃO ENTRE CONTROLE INTERNO E UNIDADES GESTORAS VINCULADAS: UMA ANÁLISE NA 5ª INSPETORIA DE CONTABILIDADE E FINANÇAS DO EXÉRCITO
Authors: Santana Sergio Luis Tosta de , Behling Hans Peder
Published: January 2022

A comunicação entre Unidade de Controle Interno (UCI) e Unidades Gestoras Vinculadas (UGV), organizações da Administração Pública, tem essencial relevância para que os assuntos tratados entre elas sejam perfeitamente compreendidos. A Nota Informativa Especial da 5ª Inspetoria de Contabilidade e Finanças do Exército (NIEsp), meio de comunicação entre UCI e UGV, consolida normas, orientações e interpretações sobre temas variados, acerca da correta maneira de execução de procedimentos pelos agentes da administração (Agts. Adms.) no âmbito do Exército Brasileiro. Assim, em um contexto que imprime a relevância da comunicação organizacional, o presente estudo tem como objetivo geral aferir a eficácia da NIEsp, na comunicação entre UCI e UGV. O método utilizado foi a pesquisa exploratória bibliográfica, associada à abordagem quantitativa com base em uma pesquisa aplicada, com as percepções das UGVs. Os resultados apontaram significância na utilização da NIEsp pelos Agts. Adms., demonstrando a importância da comunicação entre as unidades.
INOVAÇÃO E CONTRIBUIÇÃO DO DESIGN THINKING: MAPEAMENTO BIBLIOMÉTRICO SOBRE A PRODUÇÃO ACADÊMICA NAS BASES SCOPUS E WEB SCIENCE
Authors: Aragão Elisangela De Menezes , Jesus Vania De , Carvalho Ramon Santos , Santos Mario Jorge Campos dos
Published: January 2022

Começam a despontar, nas diversas áreas de conhecimento, diferentes tipos de inovação, oriundos de metodologias como Design Thinking, que desempenham um papel importante nas organizações, funcionando como facilitadoras na apresentação de novas soluções que possibilitam melhores resultados.  Este artigo tem o objetivo de apresentar a relação entre Inovação e metodologias para o despertar criativo, alinhada ao Design Thinking, por meio da produção acadêmica no período de 2015 a 2020, utilizando a bibliometria. Para o alcance do objetivo deste estudo, utilizaram-se indicadores bibliométricos na análise e avaliação dos artigos nas bases de dados Scopus e Web of Science. Obtiveram-se, na base Scopus, 92 artigos e, na Web of Science, 83, no período de 2015 a 2020, mostrando um espaço para as pesquisas neste contexto.  Destaca-se pela quantidade de artigos o ano de 2018. Observou-se, por fim, que este tema é de interesse de várias áreas de conhecimentos, apesar de a maior concentração ser nas áreas administração de negócios, engenharia, ciência da computação e ciências sociais, outras áreas também têm contribuído com artigos, caracterizando que este é um tema multidisciplinar.
SUSTENTABILIDADE ORGANIZACIONAL E SUAS MÉTRICAS: REVISÃO SISTEMÁTICA UTILIZANDO O MÉTODO PRISMA
Authors: Stefani Silvio Roberto , Delgado Catarina
Published: January 2022

São diversos os benefícios da utilização de indicadores e métricas de sustentabilidade organizacional,e referem-se à possível antecipação de condições e tendências, fornecimento de avisos de possíveis ocorrências e situações que evitem danos aos aspectos econômico, social e ambiental e auxílio nos processos de gestão. O objetivo deste estudo foi analisar as métricas de sustentabilidade organizacional, identificadas na literatura acadêmica nos últimos cinco anos. Seguindo a metodologia PRISMA, foram relacionadas sete pesquisas relevantes e enquadradas nos critérios de seleção. As principais contribuições, por meio da revisão sistemática, apontaram para estudos compostos de diferentes aspectos (empresas, cidades, regiões) ligados à sustentabilidade. Foram diversas métricas identificadas, algumas focando mais aspectos sociais da população e ou funcionários e outras mais os aspectos ambientais e seus impactos na sociedade e nas organizações. As limitações do estudo são decorrentes do método escolhido que considerou os últimos cinco anos na base Scopus e artigos completos em inglês.
AS METODOLOGIAS ATIVAS NA PERCEPÇÃO DOS DOCENTES E DISCENTES DO CURSO DE ADMINISTRAÇÃO E ECONOMIA DA UAST/UFRPE
Authors: Ferreira Renan Silva , Andrade Maria Rickaely
Published: January 2022

Este estudo objetiva analisar a percepção dos docentes e discentes acerca das metodologias ativas utilizadas nos cursos de Administração e Economia da Unidade Acadêmica de Serra Talhada - Universidade Federal Rural de Pernambuco (UAST/UFRPE). Ele foi realizado por meio de uma pesquisa bibliográfica (Base Scielo) e híbrida, mediante utilização de dois questionários on-line, estruturados em 16 perguntas, contendo uma amostra com 15 docentes respondentes, e outro com 12 perguntas, contendo uma amostra de 93 discentes respondentes, dos cursos estudados. Dessa forma, é possível verificar que, majoritariamente, existem professores formados em Administração, com 2 a 19 anos de atuação, e em ambas as atuações, existem aqueles que conhecem as metodologias ativas, mas entendem que elas ainda não são facilmente compreendidas pelos discentes. Os estudos dirigidos, sala de aula invertida, seminários e debates são provenientes de interesse dos docentes e apontados como os métodos que mais contribuem para a aprendizagem individual e coletiva, principalmente, pela dificuldade em disciplinas com predominância em cálculos.
CERVEJA ARTESANAL: DESVENDANDO AS PRÁTICAS DE PRODUÇÃO E CONSUMO ENTRE MULHERES
Authors: Salume Paula Karina , Silva Fabiana Ferreira da , Freitas Rodrigo Cassimiro de
Published: January 2022

A produção de cerveja artesanal tem despertado curiosidade e conquistado estudiosos e admiradores. Entre eles, ressalta-se a participação do público feminino, que, além de ter participação expressiva no consumo, também vem ocupando espaço de destaque como produtor da bebida. O presente artigo teve como objetivo aprender, interpretar e compreender as práticas de produção de cerveja artesanal realizadas por mulheres, na modalidade homebrewing, ao evidenciarem os aspectos materiais, sociais e simbólicos, inerentes a essas práticas. Para tanto, adotaram-se, como lente de investigação, elementos da Teoria da Prática, tais como regras, estruturas teleoafetivas, motivações e conhecimentos que permeiam a produção de cerveja artesanal por mulheres. Empregou-se a pesquisa qualitativa, descritiva, e os dados foram coletados no decorrer de seis processos de produção de cerveja artesanal por mulheres, com registros de imagens, diário de campo e entrevistas. Os resultados permitiram identificar, entre outros aspectos, que essas mulheres são estimuladas a produzir cerveja tanto para consumo próprio, como pelo prazer e pela satisfação de compartilharem a bebida e serem reconhecidas.
Ομιλούντα σώματα
Authors: Κεκές Χρήστος
Published: January 2022

Η μη λεκτική επικοινωνία, δηλαδή οι σωματικές στάσεις και κινήσεις, οι μορφασμοί του προσώπου κτλ., αποτελεί θεμελιώδες στοιχείο της ανθρώπινης συμπεριφοράς. Κατά την αρχαιότητα, οι άνθρωποι υλοποιούσαν ποικίλες χειρονομίες και λάμβαναν διάφορες στάσεις του σώματος, κατά την καθημερινή τους συναναστροφή, την επίδειξη πίστης και υποτέλειας στην άρχουσα τάξη, την προβολή της κοινωνικής τους ταυτότητας, επιτελώντας τις λατρευτικές τους δράσεις κοκ. Τα τελευταία χρόνια ολοένα και αυξάνεται το πλήθος των μελετών που προσλαμβάνουν τις χειρονομίες του αρχαίου κόσμου ως ένα μείζον ερευνητικό πεδίο. Η παρούσα διδακτορική διατριβή εντάσσεται στο παραπάνω ερευνητικό πλαίσιο και εστιάζει στους πολιτισμούς της Αιγύπτου και του Αιγαίου με χρονικό ορίζοντα την Εποχή του Χαλκού. Στην παρούσα διδακτορική διατριβή επιχειρείται μία συνθετική και ενδελεχής μελέτη των χειρονομιών που απαντώνται στην αρχαία αιγυπτιακή και την αιγαιακή τέχνη και στην αιγυπτιακή κειμενογραφία. Αναλύονται οι ποικίλοι συμβολισμοί που προσλάμβανε το χέρι στην αρχαία Αίγυπτο και τον αιγαιακό χώρο, καθώς και ο τελετουργικός ρόλος και η σημασία των χειρονομιών για την επίτευξη του προσδοκώμενου αποτελέσματος ποικίλων αιγυπτιακών και αιγαιακών τελετουργιών. Ιδιαίτερη έμφαση δίνεται στην αναγνώριση και ανάλυση παράλληλων αιγυπτιακών και αιγαιακών τελετουργικών χειρονομιών. Οι παράλληλες χειρονομίες εντάσσονται στο πλαίσιο μιας «χειρονομιακής κοινής» μεταξύ της Αιγύπτου και του Αιγαίου, κατά την Εποχή του Χαλκού. Αυτή προβάλλει την κοινή καλλιτεχνική έκφραση, την υιοθέτηση κοινών τρόπων απόδοσης της κοινωνικής ιεραρχίας στους πολιτισμούς της Αιγύπτου και του Αιγαίου και την υλοποίηση κοινών σωματικών κινήσεων, κατά την επιτέλεση των λατρευτικών τους πρακτικών. Καθίσταται σαφής η ανταλλαγή εικονογραφικών προτύπων και ιδεών μεταξύ των πολιτισμών της Αιγύπτου και του Αιγαίου, κατά την Εποχή του Χαλκού, και τεκμηριώνονται οι στενές επαφές τους και στο πεδίο των χειρονομιών.
Review of: Alkis Charalampidis,ΜΠΑΡΟΚ: ΑΡΧΙΤΕΚΤΟΝΙΚΗ, ΓΛΥΠΤΙΚΗ, ΖΩΓΡΑΦΙΚΗ [BAROQUE: ARCHITECTURE, SCULPTURE, PEINTURE], Kalliopi Tzimagiorgi (éd.), Thessalonique: University Studio Press, 2017, 221 pages, 290 figures.
Authors: Drakopoulou Eugénie
Published: January 2022

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Review of: Thomas Crow,RESTORATION: THE FALL OF NAPOLEON IN THE COURSE OF EUROPEAN ART, 1812–1820, Princeton: Princeton University Press, 2018, The A.W. Mellon Lectures in the Fine Arts National Gallery of Art, Washington, D.C. Bollingen Series XXXV: vol. 64, 202 pages, 171 illustrations.
Authors: Drakopoulou Eugénie
Published: January 2022

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Review of: Alexandros, Rizos Rangavis, LE NOTAIRE, TRADUIT DU GREC MODERNE PAR ÉTIENNE DE MOÜY/MUKAVELAT MUHARRIRI, YUNAN EDEBIYATINDAN TÜRKÇEYE ÇEVRILMIŞ VE KARAMANLICA YAZIYLA 1889–1890 YILLARINDA TEFRIkA EDILMIŞ BIR ROMAN,éds Evangelia balta et Niki Stavridi,Istanbul, The Isis Press, 2018, 113 + 167 pages.
Authors: Sfoini Alexandra
Published: January 2022

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Roots ancient or medieval? Nikolaos Politis, modern Greek folklore studies and ancient Greek religion
Authors: Marinis Agis
Published: January 2022

The question posed by the title can be reformulated in the following manner: to what extent has it been possible or desirable to connect modern Greek customs with ancient ones? not customs in general, but more precisely religious customs. Greek folklore studies typically begin with Nikolaos Politis, professor at the University of Athens, the first to introduce the term λαογραφία (meaning “folklore studies”) towards the end of the nineteenth century. Yet, we need to revert to at least as far back as the time prior to the Greek Revolution, that is, the period of the Greek enlightenment, in order to trace the beginnings of the shaping of the ideological framework of modern Greek folklore studies. it is well known and has aptly been pointed out, also in connection with Greek folklore studies, that for the Greeks the enlightenment movement went hand in hand with a specific form of romanticism. The Greek idea of the nation developed within the framework of the Romantic movement and on the basis of the connection between “us” and “the ancients”. How, then, were modern Greek folk customs that were not firmly related to the orthodox church incorporated in this new cultural narrative?
Introduction: Modern Greek theatre on the threshhold of the twentieth and twenty-first centuries
Authors: Grigoriou Rea
Published: January 2022

The 1990s witnessed a major turning point in the development of modern Greektheatre. Researchers of the last period of the twentieth century and the beginningof this century have observed not only a complex concentration of agitation,transformation and transition, but also moments of uncertainty; a compositionof contrasting new phenomena mixed with old theatrical practices, andpromising innovative beginnings accompanied by regression. This landscapeclearly reflects the dynamic developments in Greek political and national life.
A visit to the our stage festival: Participation, inclusion and sharing at the Bürgerbühne Dresden
Authors: Pipinia Ioulia
Published: January 2022

In 2009 Staatsschauspiel Dresden, the state theatre of Saxony, became the first playhouse in Germany to include, in the company’s structure and repertoire, a Bürgerbühne, a stage dedicated to documentary and participatory theatre. Within ten years, Dresden’s prolific and acclaimed model of a citizens’ stage became a thriving and active example of inclusion and participation in theatre arts. In May 2019, Our Stage, the 4th European festival of, and on, citizens’ theatre was held in Dresden, offering a full week of performances, seminars, talks, workshops and discussions on various aspects of participatory theatre. The article offers a partial account of the festival and its performances in order to trace recent developments in applied, documentary and participatory theatre; it also tentatively attempts to address the notions of participation, inclusion and sharing in relation to contemporary Greek theatre and its performances.
The Greeks under the Jurisdiction of the Archbishop of Karlovci in the Eighteenth Century
Authors: Vasin Goran , Ninković Nenad , Radulović Ifigenija
Published: January 2022

In the territory of the Habsburg Monarchy during the eighteenth century, the only Orthodox Church whose jurisdiction was recognised by the imperial authorities was that of the Archbishopric of Karlovci, which up to 1766 was an autonomous part of the Patriarchate of Peć. The believers who were part of this archbishopric had the freedom to profess their religion, which is why the Greeks who took up temporary residence in the towns of the Habsburg Monarchy turned to its archbishop when seeking their religious rights. However, there was an important difference in the status of the Greeks and the Serbs, since the former would not become subjects of the Habsburg Monarchy on a large scale until the 1760s while the former were already subjects. Due to their shared religion, in smaller settlements where they were a minority the religious needs of the Greeks were met within the existing Serbian parishes. This article describes the development of Greekparishes under the administration of the archbishop of Karlovci, how the authorities treated them and how they attained their religious rights.
Diego Venturino (éd.), OEuvres complètes de Voltaire
Authors: Sfoini Alexandra
Published: January 2022

Review of: Olga Katsiardi-Hering (ed.), Βενετικοί χάρτες της Πελοποννήσου, τέλη 17ου–αρχές 18ου αιώνα: Από τη συλλογή του Πολεμικού Αρχείου της Αυστρίας [Venetian maps of the Peloponnese, late 17th–early 18th centuries: From the Austrian War Archive collection]
Vassiliki Theodorou and Despina Karakatsani, Strengthening Young Bodies, Building the Nation: A Social History of Child Health and Welfare in Greece (1890–1940)
Authors: Gardikas Katerina
Published: January 2022

Review of: Vassiliki Theodorou and Despina Karakatsani, Strengthening Young Bodies, Building the Nation: A Social History of Child Health and Welfare in Greece (1890–1940)
Alternative Facts, Alternative Sciences: The Development of the Concept in Medieval Islam and Its Historical Consequences
Authors: Gutas Dimitri
Published: January 2022

The perception of reality, and of what is real and what false, as unproblematic and self-evident in stable societies hides the fact that reality as perceived by members of a society is socially and politically generated. The generation through political fiat of an alternative reality presented as alternative facts in the Unites States during the Trump administration, and the astounding espousal of that alternative reality by nearly half of the population, is a striking demonstration of this fact. In this paper, the development inmedieval Islam of the concept of alternative facts as alternative scientific reality is traced to the historical developments in the Middle East in the eleventh and twelfth centuries, with an account of their consequences which persist to the present day.
Olga Katsiardi-Hering, Anastasia Papadia-Lala, Katerina Nikolaou and Vangelis Karamanolakis (eds.), Έλλην, Ρωμηός, Γραικός: Συλλογικοί προσδιορισμοί και ταυτότητες [Hellene, Romios, Greek: Collective designations and identities]
Authors: Chrissidis Nikolaos
Published: January 2022

Review of:Olga Katsiardi-Hering, Anastasia Papadia-Lala, Katerina Nikolaou and Vangelis Karamanolakis (eds.), Έλλην, Ρωμηός, Γραικός: Συλλογικοί προσδιορισμοί και ταυτότητες [Hellene, Romios, Greek: Collective designations and identities]
Lateral versus posterior surgical approach for the treatment of supracondylar humeral fractures in children: a systematic review and meta-analysis
Authors: Irianto Komang Agung , Pradana I Putu Gede Pradnyadewa , De Vega Brigita
Published: January 2022

Background: Supracondylar humeral fracture (SHF) is the most common type of fracture in children. Moreover, lateral and posterior surgical approaches are the most frequently chosen approaches for open reduction surgery in displaced SHF when C-arm is unavailable. However, previous literature showed mixed findings regarding functional and cosmetic outcomes. Currently, no systematic review and meta-analysis has compared these two procedures. 

Methods: Our protocol was registered at PROSPERO (registration number CRD42021213763). We conducted a comprehensive electronic database search in MEDLINE, EMBASE, and CENTRAL. Two independent reviewers screened the title and abstract, followed by full-text reading and study selection based on eligibility criteria. The quality of the selected studies was analyzed with the ROBINS-I tool. Meta-analysis was carried out to compare the range of motion (functional outcome) and cosmetic outcome according to Flynn’s criteria. This systematic review was conducted based on PRISMA and Cochrane handbook guidelines. 

Results: Our initial search yielded 163 studies, from which we included five comparative studies comprising 231 children in the qualitative and quantitative analysis. The lateral approach was more likely to result in excellent (OR 1.69, 95% CI [0.97-2.93]) and good (OR 1.12, 95% CI [0.61-2.04]) functional outcomes and less likely to result in fair (OR 0.84, 95% CI [0.34-2.13]) and poor (OR 0.42, 95% CI [0.1-1.73]) functional outcomes compared to the posterior approach. In terms of cosmetic results, both approaches showed mixed findings. The lateral approach was more likely to result in excellent (OR 1.11, 95% CI [0.61-2.02]) and fair (OR 1.18, 95% CI [0.49-2.80]) but less likely to result in good (OR 0.79, 95% CI [0.40-1.55]) cosmetic outcomes. However, none of these analyses were statistically significant (p> 0.05). 

Conclusion: Lateral and posterior surgical approaches resulted in satisfactory functional and cosmetic outcomes. The two approaches are comparable for treating SHF in children when evaluated with Flynn’s criteria.
Crystal structure of Pseudomonas aeruginosa FabB C161A, a template for structure-based design for new antibiotics
Authors: Yadrykhins'ky Vladyslav , Georgiou Charis , Brenk Ruth
Published: January 2022

Background: FabB (3-oxoacyl-[acyl-carrier-protein] synthase 1) is part of the fatty acid synthesis II pathway found in bacteria and a potential target for antibiotics. The enzyme catalyses the Claisen condensation of malonyl-ACP (acyl carrier protein) with acyl-ACP via an acyl-enzyme intermediate. Here, we report the crystal structure of the intermediate-mimicking Pseudomonas aeruginosa FabB (PaFabB) C161A variant.

Methods: His-tagged PaFabB C161A was expressed in E. coli Rosetta DE3 pLysS cells, cleaved by TEV protease and purified using affinity and size exclusion chromatography. Commercial screens were used to identify suitable crystallization conditions which were subsequently improved to obtain well diffracting crystals.

Results: We developed a robust and efficient system for recombinant expression of PaFabB C161A. Conditions to obtain well diffracting crystals were established. The crystal structure of PaFabB C161A was solved by molecular replacement at 1.3 Å resolution. Binding site comparison between PaFabB and PaFabF revealed a conserved malonyl binding site but differences in the fatty acid binding channel.

Conclusions: The PaFabB C161A crystal structure can be used as a template to facilitate the design of FabB inhibitors.
Setting Limits on Screen Time for Children (6-to-12 Years): The Integral Role of Parents and Educators.
Authors: Hastie Megan
Published: January 2022

This paper investigates the effects of screen time on child development and cognition and the setting of ‘safe’ screen time limits for young children, specifically children aged 6-to-12 years. Guidelines on screen time vary across constituencies, and the debate around screen time is contentious with many questions yet to be answered. A review of literature was undertaken to compare current screen time recommendations against the evidence from Neuroscience, Psychiatry, Psychology and Pediatrics that quantify screen time effects on the children's brain development. Based on this comparison, conclusions are made that can guide education policies around ‘remote learning’ and ‘home schooling’ to align them with the available research on the effects of screen time on children and inform a re-evaluation of the role of parents and educators in the setting of ‘safe’ limits on screen time.
Testing for sensory threshold in drinking water with added calcium: a first step towards developing a calcium fortified water
Authors: Cormick Gabriela , Matamoros Natalia , Romero Iris B. , Perez Surya M. , White Cintia , Watson Dana Z. , Belizán José M. , Sosa Miriam , Gugole Ottaviano M. Fernanda , Elizagoyen Eliana , Garitta Lorena
Published: January 2022

Background: Food fortification is an effective strategy that has been recommended for improving population calcium inadequate intakes. Increasing calcium concentration of water has been proposed as a possible strategy to improve calcium intake. The objective of this study was to determine the sensory threshold of different calcium salts added to drinking water using survival analysis.

Methods: We performed the triangle test methodology for samples of water with added calcium using three different calcium salts: calcium chloride, calcium gluconate and calcium lactate. For each salt, a panel of 54 consumers tested seven batches of three water samples. Data were adjusted for chance and sensory threshold was estimated using the survival methodology and a discrimination of 50%.

Results: The threshold value estimation for calcium gluconate was 587 ± 131 mg/L of water, corresponding to 25% discrimination, for calcium lactate was 676 ± 186 mg/L, corresponding to 50% discrimination, and for calcium chloride was 291 ± 73 mg/L, corresponding to 50% discrimination.

Conclusions: These results show that water with calcium added in different salts and up to a concentration of 500 mg of calcium/L of water is feasible. The calcium salt allowing the highest calcium concentration with the lowest perceived changes in taste was calcium gluconate. Future studies need to explore stability and acceptability over longer periods of time.
Effect of taurine administration on symptoms, severity, or clinical outcome of dilated cardiomyopathy and heart failure in humans: a systematic review
Authors: McGurk Kathryn A. , Kasapi Melpomeni , Ware James S.
Published: January 2022

Background: Taurine, 2-aminoethanesulfonic acid, is an amino acid found in animal products. Taurine is produced for human consumption as a supplement and ingredient in beverages. Supplementation is a safe, inexpensive, and effective treatment for dilated cardiomyopathy (DCM) in domestic mammals, however it is currently unlicensed in Europe and the United States for human medical treatment. Recent genome-wide association studies of DCM have identified the locus of the taurine transporter (SLC6A6). To assess whether taurine supplementation may be a novel therapeutic option for DCM, we undertook a systematic review.

Methods: Four electronic databases (PubMed, Cochrane Central Register, Web of Science, Biomed Central) were searched until 11/03/21. Included studies of human participants reported measured phenotypes or symptoms for cardiomyopathy, heart failure (HF), or altered left ventricle structure or function, administering taurine in any formulation, by any method. Non-English articles were excluded. Meta-analysis was completed in R software (version 3.6.0). The Newcastle-Ottawa Scale quality assessment score (NOQAS) tool was used to assess bias.

Results: 285 articles were identified, of which eleven met our criteria for inclusion. Only one paper was deemed “high quality” using the NOQAS tool. Taurine supplementation varied across studies; by dose (500 mg to 6g per day), frequency (once to thrice daily), delivery method (tablet, capsule, drink, powder), and duration (2 to 48 weeks). Patient inclusion was all-cause HF patients with ejection fraction (EF) <50% and no study was specific to DCM. While improvements in diastolic and systolic function, exercise capacity, and haemodynamic parameters were described, only EF and stroke volume were measured in enough studies to complete a meta-analysis; the association was not significant with all-cause HF (P<0.05). No significant safety concerns were reported.

Conclusions: A formal clinical trial is needed to address whether taurine supplementation is beneficial to the approximately 1/250 individuals with DCM in the population.
PSYCHOLOGICAL FEATURES OF PATIENTS WITH TYPE
Authors: Moskalenko O. L. , Smirnova O. V. , Kasparov E. V. , Kasparova I. E.
Published: January 2022

The article is devoted to the study of psychoemotional characteristics of patients with diabetes mellitus. Conducting psychological techniques, testing, questioning patients will reveal anxiety-depressive states and psychological characteristics of patients with type I diabetes and type II diabetes for successful disease control. It is necessary to strive for the examination of such patients with an individual approach for each. To improve the quality of life of such patients, it is necessary to search for effective approaches in the education system of patients with type I diabetes and type II diabetes with the participation of psychologists.
Work of Organizations After the Pandemic
Authors: Aristova A. , Aristova A. , Ashurbekov R.
Published: January 2022

This article is devoted to the development of organizations in the period of unexpected and rapidly changing conditions caused by the Covid-19 pandemic, and the analysis of whether organizations were ready to perceive the new reality and use this situation to rethink the norms of work, to apply innovative methods and technologies of the organization that were not previously available. The article discusses the statistics on the use of such a method of organizing work as remote work, as well as the advantages of electronic document management, the spread of modern technologies in organizing joint work.
Research on the Importance of Digital Etiquette As a Competence of a Modern Employee
Authors: Gashe E. , Chalova A. , Shul'zhenko I. , Lobacheva A.
Published: January 2022

This article is devoted to the study of the current topic - the importance of digital etiquette as an employee competence. The percentage of modern employee's communications in the online space is increasing, more and more work issues are solved using computer technology and electronic systems. This trend requires the development of a new digital culture of communication, which includes the rules that are necessary to build clear business relationships. In order to form a relevant, understandable and succinct set of recommendations, it is required to assess the current level of knowledge of digital etiquette. To do this, a survey was compiled that included questions defining human behavior in various situations that may arise during online business communications. Based on the survey with 120 respondents, recommendations on business etiquette topics were developed.