bluuebunny/crossref_metadata_2025 huggingface dataset:
Advanced glycation endproducts mediate chronic kidney injury with characteristic patterns in different stages
Authors: Huang Xiaoxia , Li Bingyu , Hu Jiaqing , Liu Zhuanhua , Li Dongping , Chen Zhenfeng , Huang Hang , Chen Yanjia , Guo Xiaohua , Cui Yun , Huang Qiaobing
Published: September 2022

Advanced glycation endproducts (AGEs) have been confirmed to play a causative role in the development of diabetic nephropathy (DN). In this study, we revealed that AGE-induced kidney injury with characteristic patterns in different stages and moesin phosphorylation plays a role in these processes. In WT mice treated with AGE-modified bovine serum albumin (AGE-BSA), distinct abnormal angiogenesis in Bowman’s capsule of the kidney emerged early after 1 m under AGE-BSA stimulation, while these neovessels became rare after 6 m. AGE-BSA also induced glomerular hypertrophy and mesangial expansion at 1 m but glomerular atrophy and fibrosis at 6 m. Electron microscopy imaging demonstrated the damage of foot process integrity in podocytes and the uneven thickening of the glomerular basement membrane in the AGE-BSA-treated group, which was more significant after 6 m of AGE-BSA treatment than 1 m. The kidney dysfunction appeared along with these AGE-induced morphological changes. However, these AGE-BSA-induced pathological changes were significantly attenuated in RAGE-knockout mice. Moreover, moesin phosphorylation was accompanied by AGE-BSA-induced alterations and moesin deficiency in mice attenuated by AGE-BSA-induced fibrosis. The investigation on glomerular endothelial cells (GECs) also confirmed that the phosphorylation of moesin T558 is critical in AGE-induced tube formation. Overall, this study suggests that AGEs mediate kidney injury with characteristic patterns by binding with RAGE and inducing moesin phosphorylation.
Comparative transcriptome analysis identified ChlH and POLGAMMA2 in regulating yellow-leaf coloration in Forsythia
Authors: Zhang Man , Shen Jianshuang , Wu Yutong , Zhang Xiaolu , Zhao Zhengtian , Wang Jia , Cheng Tangren , Zhang Qixiang , Pan Huitang
Published: September 2022

Leaf color is one of the most important features for plants used for landscape and ornamental purposes. However, the regulatory mechanism of yellow leaf coloration still remains elusive in many plant species. To understand the complex genetic mechanism of yellow-leaf Forsythia, we first compared the pigment content and leaf anatomical structure of yellow-leaf and green-leaf accessions derived from a hybrid population. The physiological and cytological analyses demonstrated that yellow-leaf progenies were chlorophyll deficient with defected chloroplast structure. With comparative transcriptome analysis, we identified a number of candidate genes differentially expressed between yellow-leaf and green-leaf Forsythia plants. Among these genes, we further screened out two candidates, ChlH (magnesium chelatase Subunit H) and POLGAMMA2 (POLYMERASE GAMMA 2), with consistent relative-expression pattern between different colored plants. To verify the gene function, we performed virus-induced gene silencing assays and observed yellow-leaf phenotype with total chlorophyll content reduced by approximately 66 and 83% in ChlH-silenced and POLGAMMA2-silenced plants, respectively. We also observed defected chloroplast structure in both ChlH-silenced and POLGAMMA2-silenced Forsythia. Transient over-expression of ChlH and POLGAMMA2 led to increased chlorophyll content and restored thylakoid architecture in yellow-leaf Forsythia. With transcriptome sequencing, we detected a number of genes related to chlorophyll biosynthesis and chloroplast development that were responsive to the silencing of ChlH and POLGAMMA2. To summarize, ChlH and POLGAMMA2 are two key genes that possibly related to yellow-leaf coloration in Forsythia through modulating chlorophyll synthesis and chloroplast ultrastructure. Our study provided insights into the molecular aspects of yellow-leaf Forsythia and expanded the knowledge of foliage color regulation in woody ornamental plants.
Enhancement of photosynthesis efficiency and yield of strawberry (Fragaria ananassa Duch.) plants via LED systems
Authors: Guiamba Helio Dos Santos Suzana , Zhang Xiwen , Sierka Edyta , Lin Kui , Ali Muhammad Moaaz , Ali Waleed M. , Lamlom Sobhi F. , Kalaji Hazem M. , Telesiński Arkadiusz , Yousef Ahmed Fathy , Xu Yong
Published: September 2022

Due to advances in the industrial development of light-emitting diodes (LEDs), much research has been conducted in recent years to get a better understanding of how plants respond to these light sources. This study investigated the effects of different LED-based light regimes on strawberry plant development and performance. The photosynthetic pigment content, biochemical constituents, and growth characteristics of strawberry plants were investigated using a combination of different light intensities (150, 200, and 250 μmol m−2 s−1), qualities (red, green, and blue LEDs), and photoperiods (14/10 h, 16/8 h, and 12/12 h light/dark cycles) compared to the same treatment with white fluorescent light. Plant height, root length, shoot fresh and dry weight, chlorophyll a, total chlorophyll/carotenoid content, and most plant yield parameters were highest when illuminated with LM7 [intensity (250 μmol m−2 s−1) + quality (70% red/30% blue LED light combination) + photoperiod (16/8 h light/dark cycles)]. The best results for the effective quantum yield of PSII photochemistry Y(II), photochemical quenching coefficient (qP), and electron transport ratio (ETR) were obtained with LM8 illumination [intensity (250 μmol m−2 s−1) + quality (50% red/20% green/30% blue LED light combination) + photoperiod (12 h/12 h light/dark cycles)]. We conclude that strawberry plants require prolonged and high light intensities with a high red-light component for maximum performance and biomass production.
Euryale Small Auxin Up RNA62 promotes cell elongation and seed size by altering the distribution of indole-3-acetic acid under the light
Authors: Huang Zhi-heng , Bao Ke , Jing Zong-hui , Wang Qian , Duan Hui-fang , Zhang Sen , Tao Wei-wei , Wu Qi-nan
Published: September 2022

Euryale (Euryale ferox Salisb.) is an aquatic crop used as both food and drug in Asia, but its utilization is seriously limited due to low yield. Previously, we hypothesized that Euryale small auxin up RNAs (EuSAURs) regulate seed size, but the underlying biological functions and molecular mechanisms remain unclear. Here, we observed that the hybrid Euryale lines (HL) generate larger seeds with higher indole-3-acetic acid (IAA) concentrations than those in the North Gordon Euryale (WT). Histological analysis suggested that a larger ovary in HL is attributed to longer cells around. Overexpression of EuSAUR62 in rice (Oryza sativa L.) resulted in larger glumes and grains and increased the length of glume cells. Immunofluorescence and protein interaction assays revealed that EuSAUR62 modulates IAA accumulation around the rice ovary by interacting with the rice PIN-FORMED 9, an auxin efflux carrier protein. Euryale basic region/leucine zipper 55 (EubZIP55), which was highly expressed in HL, directly binds to the EuSAUR62 promoter and activated the expression of EuSAUR62. Constant light increased the expression of both EubZIP55 and EuSAUR62 with auxin-mediated hook curvature in HL seedlings. Overall, we proposed that EuSAUR62 is a molecular bridge between light and IAA and plays a crucial role in regulating the size of the Euryale seed.
Comparison of the pathway structures influencing the temporal response of salicylate and jasmonate defence hormones in Arabidopsis thaliana
Authors: Stroud Erin A. , Jayaraman Jay , Templeton Matthew D. , Rikkerink Erik H. A.
Published: September 2022

Defence phytohormone pathways evolved to recognize and counter multiple stressors within the environment. Salicylic acid responsive pathways regulate the defence response to biotrophic pathogens whilst responses to necrotrophic pathogens, herbivory, and wounding are regulated via jasmonic acid pathways. Despite their contrasting roles in planta, the salicylic acid and jasmonic acid defence networks share a common architecture, progressing from stages of biosynthesis, to modification, regulation, and response. The unique structure, components, and regulation of each stage of the defence networks likely contributes, in part, to the speed, establishment, and longevity of the salicylic acid and jasmonic acid signaling pathways in response to hormone treatment and various biotic stressors. Recent advancements in the understanding of the Arabidopsis thaliana salicylic acid and jasmonic acid signaling pathways are reviewed here, with a focus on how the structure of the pathways may be influencing the temporal regulation of the defence responses, and how biotic stressors and the many roles of salicylic acid and jasmonic acid in planta may have shaped the evolution of the signaling networks.
An appressorium membrane protein, Pams1, controls infection structure maturation and virulence via maintaining endosomal stability in the rice blast fungus
Authors: Wang Jing , Wang Qing , Huang Pengyun , Qu Yingmin , Huang Zhicheng , Wang Huan , Liu Xiao-Hong , Lin Fu-Cheng , Lu Jianping
Published: September 2022

The rice blast fungus Magnaporthe oryzae spores differentiate and mature into functional appressoria by sensing the host surface signals. Environmental stimuli are transduced into cells through internalization during appressorium formation, such as in the cAMP-PKA pathway. Here, we describe a novel contribution to how appressoria mature on the surface of a leaf, and its connection to endosomes and the cAMP-PKA pathway. An appressorium membrane-specific protein, Pams1, is required for maintaining endosomal structure, appressorium maturation, and virulence in M. oryzae. During appressorium development, Pams1 was translocated from the cell membrane to the endosomal membrane. Deletion of PAMS1 led to the formation of two types of abnormal appressoria after 8 h post inoculation (hpi): melanized type I had a reduced virulence, while pale type II was dead. Before 8 hpi, Δpams1 formed appressoria that were similar to those of the wild type. After 8 hpi, the appressoria of Δpams1 was differentiated into two types: (1) the cell walls of type I appressoria were melanized, endosomes were larger, and had a different distribution from the wild type and (2) Type II appressoria gradually stopped melanization and began to die. The organelles, including the nucleus, endosomes, mitochondria, and endoplasmic reticula, were degraded, leaving only autophagic body-like vesicles in type II appressoria. The addition of exogenous cAMP to Δpams1 led to the formation of a greater proportion of type I appressoria and a smaller proportion of type II appressoria. Thus, defects in endosomal structure and the cAMP-PKA pathway are among the causes of the defective appressorium maturation and virulence of Δpams1.
High-resolution mapping reveals a Ht3-like locus against northern corn leaf blight
Authors: Zhu Mang , Ma Jun , Liu Xinfang , Guo Yanling , Qi Xin , Gong Xue , Zhu Yanbin , Wang Yanbo , Jiang Min
Published: September 2022

Northern corn leaf blight (NCLB), caused by the fungal pathogen Exserohilum turcicum, poses a grave threat to maize production worldwide. The resistance gene in A619Ht3, discovered decades ago, is an important genetic resource for NCLB control. By using a pair of near-isogenic lines (NILs) A619Ht3 and A619, together with the resistant and susceptible bulks derived from the cross of A619Ht3 and L3162 lines, we initially detected a Ht3-like (Ht3L) locus in bin 8.06 that was closely associated with NCLB resistance. We then performed five rounds of fine-mapping, which ultimately delimited the Ht3L locus to a 577-kb interval flanked by SNP markers KA002081 and KA002084. Plants homozygous for the Ht3L/Ht3L genotype exhibited an average reduction in diseased leaf area (DLA) by 16.5% compared to plants lacking Ht3L locus. The Ht3L locus showed extensive variation in genomic architecture among different maize lines and did not appear to contain any genes encoding canonical cell wall-associated kinases against NCLB. Moreover, the Ht3L locus was located ∼2.7 Mb away from the known Htn1 locus. We speculate that the Ht3L locus may contain a bona fide Ht3 gene or a novel NCLB resistance gene closely linked to Ht3. In practice, the Ht3L locus is a valuable resource for improving maize resistance to NCLB.
Cultivar differences in carbon and nitrogen accumulation, balance, and grain yield in maize
Authors: Li Qiang , Ren Yun , Fu Hao , Li Zhexin , Kong Fanlei , Yuan Jichao
Published: September 2022

The balance of carbon (C) and nitrogen (N) metabolism influences plant growth and development as well as yield. A two-year field experiment was conducted in a hilly region in southwest China in 2019–2020 to investigate the correlation between the accumulation and balance of C and N, as well as the grain yield of maize cultivars with contrasting N efficiencies. Using Zhenghong 311 (ZH 311) and Xianyu 508 (XY 508) as research sources, the differences in C and N accumulation and balance in maize cultivars with contrasting N efficiencies were compared to analyze the correlation between the accumulation and balance of C and N with grain yield. According to the results, the ZH 311 cultivar had higher C and N accumulation in each stage and grain yield than the XY 508 cultivar, while the C/N ratio in each stage and organ was significantly lower in ZH 311 than in XY 508, with the greatest difference occurring in the silking stage and leaf, indicating that the N-efficient cultivar ZH 311 had evident advantages in accumulation and balance of C and N and grain yield than the N-inefficient cultivar XY 508. Moreover, the C and N accumulation and grain yield increased significantly with N application, while the C/N ratio in each stage and organ decreased significantly with N application, but the differences between ZH 311 and XY 508 increased first and then decreased with the increase of N level, the optimum N level when obtaining the highest grain yield of ZH 311 (273.21 kg ha–1) was significantly lower than that of XY 508 (355.88 kg ha–1). Furthermore, grain yield was positively correlated with C (R2 = 0.9251) and N (R2 = 0.9033) accumulation, affected by pre-anthesis N (R2 = 0.9198) and post-anthesis C (R2 = 0.8632) accumulation, and negatively correlated with the C/N ratio (R2 = 0.7664), with the highest correlation between grain yield and the C/N ratio in silking stage (R2 = 0.7984) and leaf (R2 = 0.7616). In conclusion, the N-efficient cultivar ZH 311 could better coordinate the C and N balance of the plant, especially the C and N balance in the silking stage and leaf, promote photosynthetic product storage and transport, prolong the leaf function period, and make the pre-anthesis and post-anthesis C and N accumulation of ZH 311 significantly higher than those of XY 508, allowing higher grain yields.
Nano-iron oxide accelerates growth, yield, and quality of Glycine max seed in water deficits
Authors: Dola Dipanjoli Baral , Mannan Md. Abdul , Sarker Umakanta , Mamun Md. Abdullah Al , Islam Tofazzal , Ercisli Sezai , Saleem Muhammad Hamzah , Ali Baber , Pop Oana Lelia , Marc Romina Alina
Published: September 2022

Drought is one of the most destructive abiotic stresses that impact the growth, physiology, yield, and nutritional quality of seeds of crop plants. In modern agriculture, the use of nanoparticles can be beneficial due to their large surface area and higher potentiality to enter into the plant leaf during foliar application. This study aims to evaluate the effects of foliar spray containing varying doses (0, 100, and 200 ppm) of the nano-iron (Fe3O4) on the growth, physiology, yield, and seed nutritional quality of soybean under drought (40% of field capacity, FC) and well-watered (80% of FC) conditions. Leaf water status, chlorophyll content of leaves, the height of the plant, fresh leaf weight, fresh stem weight, fresh petiole weight, total dry weight, seed yield, and protein and oil content in soybean seeds were found to be suppressed by the applied drought stress. Under both drought (40% of FC) and controlled well-watered (80% of FC) conditions, the foliar application of nano-iron substantially improved the growth, physiology, yield, and quality of soybean seeds. The nanoparticles at 200 ppm increased soybean seed yield by 40.12 and 32.60% in drought and well-watered conditions, respectively, compared to the untreated plants. Furthermore, nano-iron increased the oil content of soybean seeds by 10.14 and 7.87% under drought and well-watered conditions, respectively, compared to the untreated control. Our results indicate that the application of nano-iron improved drought tolerance, yield, and seed quality of soybean, so exogenous foliar sprays of 200 ppm Fe3O4 were more effective than the other treatments in enhancing drought tolerance and can be utilized to reduce losses caused by drought stress in soybean-growing areas.
The role of psycholinguistics for language learning in teaching based on formulaic sequence use and oral fluency
Authors: Yu Yue
Published: September 2022

Psycholinguistics has provided numerous theories that explain how a person acquires a language, produces and perceives both spoken and written language, including theories of proceduralization. Learners of English as a foreign language (hereafter referred to as EFL learners) often find it difficult to achieve oral fluency, a key construct closely related to the mental state or even mental health of learners. According to previous research, this problem could be addressed by the mastery of formulaic sequences, since the employment of formulaic sequences could often promote oral fluency in the long run, reflected in the positive relationship between formulaic sequence use and oral fluency. However, there are also findings contradicting the abovementioned ones, without adequate explanations. This study aims to explore the roles of formulaic sequences in oral fluency, taking into account the relationship between formulaic sequence use and oral fluency. This study investigated 120 pieces of spoken narratives by Chinese EFL learners, using both quantitative and qualitative methods, combined with artificial intelligence techniques. Results of canonical correlation analysis showed that the frequency of formulaic sequences was significantly related to speed fluency (r = 0.563,p = 0.000) and breakdown fluency (r = 0.360,p = 0.001), while the variety of formulaic sequences was significantly related to repair fluency (r = 0.292,p = 0.035). Case studies further demonstrated that formulaic sequences could contribute to oral fluency development by promoting speed and reducing pausing when retrieved holistically, but they sometimes lost processing advantages when retrieved and processed in a word-by-word manner. The inappropriate use of formulaic sequences also neutralized the facilitative effects of formulaic sequences on repair fluency and could mirror speakers’ occasional tendency to sacrifice repair fluency for the improvement of speed and breakdown fluency when using formulaic sequences. Pedagogical implications were provided accordingly to promote sustainable oral fluency development through the use of formulaic sequences.
Consumer acceptance of autonomous delivery robots for last-mile delivery: Technological and health perspectives
Authors: Yuen Kum Fai , Cai Lanhui , Lim Yong Guang , Wang Xueqin
Published: September 2022

The unprecedented outbreak of the novel coronavirus has led to a great shift toward online retailing and accelerated the need for contactless delivery. This study investigates how technological and health belief factors influence consumer acceptance of autonomous delivery robots (ADRs). Anchored in four behavioral theories [i.e., technology acceptance model, health belief model, perceived value (VAL) theory and trust theory], a synthesized model is developed. A total of 500 valid responses were collected through an online questionnaire in Singapore, and structural equation modeling was conducted to examine the responses. The results revealed that perceived ease of use (EOU), perceived usefulness (UFN), perceived susceptibility (SUS), perceived severity (SEV), self-efficacy (SEL) and cues to action (CUE) have a positive and significant influence on consumers’ perceptions of the value of ADRs. The total effect analysis also showed that perceived VAL strongly affects consumer acceptance of ADRs. Academically, this study introduces both technological and health belief factors to explain consumer acceptance of ADRs. It also provides recommendations for policymakers and autonomous delivery robot developers on policy formulation, public communication, product design and infrastructure development.
Integrating positive psychology and spirituality in the context of climate change
Authors: Bellehumeur Christian R. , Bilodeau Cynthia , Kam Christopher
Published: September 2022

In the context of climate change and its accompanying impact on stress and mental health, we argue that positive psychology (PP) may benefit from an integration of spirituality to better support people’s wellbeing. Starting with an overview of climate change’s impact on wellbeing and health, we explore the paradoxical and complex relationship between humans and nature. Following which, we will briefly define spirituality and present an evocative metaphor of the wave to portray the evolution of the field of PP. In our conclusive remarks, we argue that the field of PP has gradually become more open to integrate spirituality (since the first wave), as it evolves towards greater complexity (in its third wave). In addition to meaning, some spiritual perspectives potentially relevant to positive psychology facilitate an ecocentric view (i.e., eco-spiritualities) which allow for a better understanding of the paradoxical human-nature relationship, as we struggle to deal with the complex issues related to climate change.
Global research trends in the subjective well-being of older adults from 2002 to 2021: A bibliometric analysis
Authors: Huang Derong , Wang Jian , Fang Huiling , Wang Xuehan , Zhang Yujie , Cao Shuo
Published: September 2022

Purpose

This study aimed to explore current developments and trends in the field of subjective well-being (SWB) of older adults at a macro level and identify research hotspots.

Methods

We included reviews and articles on the SWB of older adults in the Web of Science Core Collection published from 2002 to 2021. We used CiteSpace to draw a knowledge map of the authors, institutions, countries, references, and keywords for visual analysis and used Microsoft Excel tables to count basic information details.

Results

A total of 354 papers were included, and the number of papers published over the past two decades showed a pattern of growth. The core force of publications was primarily attributed to studies conducted in Europe, North America, Asia, and Oceania, which have relatively major issues of aging and good economic strength. However, links between states, institutions, and authors were relatively weak. Cluster analysis showed that the research field could be divided into eight topics: the application of social psychology in the study of the SWB of older adults, aging in older adults, health condition of older adults, achieving successful aging, interventions for SWB, age differences in SWB research, an economic perspective of SWB research and social support for older adults. Current research frontiers are socioeconomic status, community, intervention, participation, adjustment, validation, and personality.

Conclusion

The results of the present study provided a comprehensive picture in the research field of SWB of older adults. It showed that the mechanism, especially the bidirectional effect, between the SWB of older adults and its influencing factors is still worthy of further exploration. More research on evidence-based and intervention strategies should be conducted in the future.
Impact of the COVID-19 epidemic anxiety on college students' employment confidence and employment situation perception in China
Authors: Zheng Sining , Wu Guizhen , Zhao Jiahao , Chen Weiqi
Published: September 2022

The psychological problems and employment problems of college students have always been the focus of attention of all sectors of society. The COVID-19 epidemic has a great impact on the mental health and employment of Chinese college students. Under this background, this study discusses how epidemic anxiety affects the employment confidence and perception of employment situation of Chinese college students. Through the online questionnaire survey of 1,132 college students nationwide, and the ordinal logistic regression analysis of the survey data using Stata 16.0 software, the results show that: (1) Epidemic anxiety negatively affects Chinese college students' employment confidence and employment situation perception, and has a significant impact on employment confidence. The three control variables of employment guidance, older age and higher education have a significant positive impact on college students' employment confidence and employment situation perception. College students in the eastern region have stronger employment confidence and more optimistic employment situation perception. But the expected monthly salary is negatively correlated with employment confidence. (2) Male college students and Science and Engineering students' epidemic anxiety have a stronger negative impact on employment confidence and employment situation perception. (3) Employment guidance has a moderating effect on the relationship between epidemic anxiety, employment confidence and employment situation perception. Employment guidance can enhance college students' employment confidence and reduce their sense of employment crisis by alleviating epidemic anxiety. Combined with the research conclusions, it is proposed that the state and schools should pay attention to the psychological counseling of college students, strengthen the employment guidance of colleges and universities, vigorously support the development of small, medium-sized and micro enterprises, and improve the employment and entrepreneurship service system of college students, so as to promote the employment of college students.
A study on the influence of online reviews of new products on consumers’ purchase decisions: An empirical study on JD.com
Authors: Kang Min , Sun Bing , Liang Tian , Mao Hong-Ying
Published: September 2022

With the prevalence of the Internet and new media channels, consumer reviews have become one of the main determinants of Consumers’ purchasing decisions. This paper uses the Latent Dirichlet Allocation (LDA) model to identify the key factors that are of major concern to consumers, including design factors, laptop setup factors, logistics factors, after-sales factors, and user experience factors. And, we classify these factors into product quality factors and supporting service factors for new products. We then explore the relationship between online reviews and purchase decisions under these different factors, and also further explore the impact of interactions between online review metrics on purchase decisions. Our findings suggest that the impact of online reviews on consumer purchase decisions also varies considerably across different consumer focus factors. In addition, we find that the impact of the interaction between online review features is complex. In particular, consumers do not follow the positive guidance and make purchase decisions as we would expect when confronted with a large number of positive emotional polarity online reviews. Meanwhile, the interaction between negative emotional polarity and variance of online reviews had no significant effect on consumer purchase decisions. The variance of online reviews has a limited role in reducing consumer risk perceptions triggered by negative emotional polarity. Our study provides new evidence for the study of the impact of online reviews through text mining.
Effects of a short and intensive transcranial direct current stimulation treatment in children and adolescents with developmental dyslexia: A crossover clinical trial
Authors: Battisti Andrea , Lazzaro Giulia , Costanzo Floriana , Varuzza Cristiana , Rossi Serena , Vicari Stefano , Menghini Deny
Published: September 2022

Developmental Dyslexia (DD) significantly interferes with children’s academic, personal, social, and emotional functioning. Nevertheless, therapeutic options need to be further validated and tested in randomized controlled clinical trials. The use of transcranial direct current stimulation (tDCS) has been gaining ground in recent years as a new intervention option for DD. However, there are still open questions regarding the most suitable tDCS protocol for young people with DD. The current crossover study tested the effectiveness of a short and intensive tDCS protocol, including the long-term effects, as well as the influence of age and neuropsychological processes at baseline on reading improvements. Twenty-four children and adolescents with DD were randomly assigned to receive active tDCS during the first slot and sham tDCS during the second slot or vice versa. Five consecutive daily sessions of left anodal/right cathodal tDCS set at 1 mA for 20 min were administered over the parieto-occipital regions. Reading measures (text, high frequency word, low frequency word, and non-word lists) and neuropsychological measures (visual-spatial and verbal working memory, phoneme blending, and rapid automatized naming tasks) were collected before, immediately after, 1 week and 1 month later the treatment. Our results showed that only the active tDCS condition improved non-word reading speed immediately after and 1 month later the end of the treatment compared with baseline. In addition, the improvement in non-word reading speed was significantly correlated with age and with neuropsychological measures (verbal working memory and phoneme blending) at baseline but only in the active tDCS condition. The current crossover study contributed to enforce previous effects of tDCS, including long-term effects, on non-word reading speed and to understand the effect of age and neuropsychological processes on reading outcomes. Our findings showed that tDCS could be a low-cost and easy-to-implement treatment option with long-term effects for children and adolescents with DD.
Prevalence and correlates of suicidal ideation among older adults attending primary care clinics in Wuhan, China: A multicenter cross-sectional study
Authors: Zhu Xiao-Min , Xu Yan-Min , Wang Zong-Qin , Zhong Bao-Liang
Published: September 2022

Background

Primary care represents an ideal setting for screening for and managing suicidal older adults but the clinical epidemiology of suicidal ideation in Chinese older primary care patients remains unclear. This study investigated the prevalence and correlates of suicidal ideation in older Chinese adults receiving primary care.

Methods

This multicenter cross-sectional survey included a total of 769 older adults (≥65 years) from seven urban and six rural primary care clinics in Wuhan, China. The presence of depressive symptoms and suicidal ideation was assessed with the Geriatric Depression Scale and a single-item question “In the past 12 months, did you think about ending your life?,” respectively.

Results

The 12-month prevalence of suicidal ideation in older primary care patients was 16.6%. Significant correlates of suicidal ideation were poor economic status (vs. good, OR = 2.80, P = 0.008), heart disease (OR = 2.48, P = 0.005), chronic gastric ulcer (OR = 3.55, P = 0.012), arthritis (OR = 2.10, P = 0.042), and depressive symptoms (OR = 11.29, P < 0.001).

Conclusions

Suicidal ideation is common among older adults attending Chinese primary care clinics. It is necessary to integrate psychological crisis intervention into primary care to prevent late-life suicide.
Prescribing behavior of antidepressants for depressive disorders: A systematic review
Authors: Lam Mary K. , Lam Lawrence T. , Butler-Henderson Kerryn , King Jonathan , Clark Tahnee , Slocombe Peta , Dimarco Katherine , Cockshaw Wendell
Published: September 2022

Objective

Guidelines for the prescription of antidepressants for Depressive Disorders (DD) have been in place for a long time. However, there is a lack of systematic information on the prescribing behavior of antidepressants in evidence-based clinical practice in psychopharmacotherapy of depressive disorders. This may suggest a lack of implementation of clinical guidelines by clinicians. Existing literature mainly focuses on specific issues or medications. To provide general information on the prescribing behavior of antidepressants for depressive disorders, a systematic review of available studies since 2013 was conducted.

Methods and materials

To ensure a structured and systematic approach for the literature search and subsequent review process, the PRISMA guidelines for systematic reviews were followed. Major medical and health and psychological databases were used for the literature search. These included Ebsco Host, OVID, PubMed, Science Direct, Scopus, and Web of Science. The online application “Covidence” was employed to manage the titles collected and the full articles retrieved from the initial literature search. Upon finalizing the list of selected studies, data extraction was then conducted using a build-in function of the Covidence platform with the required information pre-set on a template for data extraction. The extracted information was tabulated and summarized in a table.

Results

Forty-one studies were identified after an extensive search of the literature following the PRISMA guidelines. Of these, 37 quantitative studies providing useful information were systematically reviewed and information extracted. There was a high level of heterogeneity among these studies with different foci or characteristics. Most studies were conducted in or utilized data obtained from hospital and primary healthcare settings. SSRIs were the most commonly prescribed type of antidepressant in the past decade, particularly among younger patients. Among these studies, antidepressants were mainly prescribed by psychiatrists with some by other physicians and general practitioners. This might reflect differences in legislation regarding professional requirements for prescribers or clinical practices.

Conclusions

A few themes that would be considered important in terms of the effect of prescription behavior on depression, specifically children/adolescents, special target populations, and off-label prescription. The results highlighted the need for more studies on a community-based approach and the role of GPs in the treatment of DD.
The correlation between economic fluctuation, workforce employment and health expenditure in the BRICS countries
Authors: Gu Lingyan , Wang Mei-Chih , Li Fangjhy
Published: September 2022

In this paper, we use the Fourier ARDL method (data from 2000 to 2019) to examine whether there is a correlation between economic fluctuation, health expenditure, and employment rate among BRICS countries. Fourier ARDL's model, the same as Bootstrap ARDL model, is to test the long-term cointegration relationship of variables; when there is cointegration, it will test whether there is a causal relationship. When there is no cointegration, short-term Granger causality between variables is tested. Our study shows that, in the long-term, whether South Africa takes economic fluctuation, employment rate or health expenditure as the dependent variable, there is a cointegration relationship with the other two independent variables, but the causal relationship is not significant. In short-term Granger causality tests, the effects of economic fluctuation in Brazil, China, and South Africa on health expenditure lag significantly by one period. Economic fluctuation in Brazil, India and China had a negative effect on employment rate, while South Africa had a positive effect. Health expenditure in Russia and India has a negative effect on employment rate, while China has a positive effect. Employment rates in China and South Africa have a significant positive effect on economic fluctuation, while Russia has a negative effect. India's employment rate has a negative effect on health expenditure, while South Africa's has a positive effect. In short-term causality tests, different countries will exhibit different phenomena. Except for economic fluctuation, where health spending is positive, everything else is negatively correlated, and all of them are positive in South Africa. Finally, we make policy recommendations for the BRICS countries on economic fluctuation, employment rates, and health expenditure.
Physical fitness data monitoring of college students based on the internet of things and blockchain
Authors: Sang Yunpeng , Wang Lijun
Published: September 2022

Contemporary college students are the pillars of the country and bear the responsibility of building a great country. College students should not only have smart brains, but also have strong bodies. The state has always attached great importance to the physical condition of college students and has promulgated a series of relevant policies and regulations to ensure the effective development of college students' physical health work. This paper aims to monitor and research college students' physical fitness data based on the Internet of Things and blockchain technology. This paper first introduces the data collection based on the Internet of Things, the Internet of Things data collection system has good versatility, ease of use, and quite rich functions, which can realize the collection and reliable transmission of different environmental data. Then focuses on the data collection and confidentiality technology based on blockchain. Each user in the blockchain system has a pair of public and private keys, and elliptic curve algorithms are usually used to generate public key cryptography. Finally, based on the Internet of Things and blockchain technology, the physical fitness data of college students is analyzed and researched. The experimental results of this paper show that, according to the data collection technology of the Internet of Things and blockchain, the analysis of variance is carried out on the data of male pull-ups and female sit-ups of 2019 students. The analysis of variance F of boys' pull-ups is 76.222, and the significance is about 0, that is, P < 0.01. The difference is very obvious, which proves that there is a significant difference in boys' pull-ups in the past 3 years. The analysis of variance F for girls' sit-ups is 89.187, and the significance is about 0. Similarly, it shows that there are significant differences in girls' sit-ups in the past 3 years. Therefore, the existing teaching mode is stabilized and physical exercise is enhanced. Meanwhile, to enhance the physical fitness of students, it is necessary to strengthen the strength of physical education teachers and increase the introduction of sports talents and business training.
Evaluation of the vulnerability to public health events in the Guangdong-Hong Kong-Macao Greater Bay Area
Authors: Cui Wenjing , Chen Jing , Shen Huawen , Zhang Yating , Liu Shuting , Zhou Yiting
Published: September 2022

With the continuous improvement in the integration of urban agglomeration, a multi-functional, socialized, and complex dynamic system, effective prevention and control of emergent public health events have become increasingly important. Based on the Public-Health Vulnerability-Assessment-System of Urban Agglomeration (PVUA), the temporal and spatial differentiation characteristics of vulnerability in the Guangdong-Hong Kong-Macao Greater Bay Area (GBA) for the period of 2015-2019 are explored, and the vulnerable cities to public health events are identified in this area. The results can be summarized as follows: (1) The overall vulnerability to public health events in GBA decreases in the investigated period. (2) In the temporal dimension, accompanied by social and economic development, the sensitivity to public health events increases in GBA, and the coping capacity change from stable fluctuation to rapid improvement. (3) From the spatial dimension, the sensitivity level in GBA is low in the west, relatively high in the middle, and high in the southeast; the coping capacity is high in the southeast and low in the northwest; the collaborative governance capacity presents a spatial pattern of being low in the south and high in the north. (4) In the period of study, the vulnerability to public health events in Guangzhou and Jiangmen is stable at the lowest level, while that in Zhaoqing, Foshan, and Hong Kong SAR (Special Administrative Region) gradually reduces; the vulnerability in Shenzhen, Zhuhai, and Dongguan is fluctuating, and that in Huizhou, Zhongshan, and Macao SAR is continually maintained at a higher and the highest level.
Anxiety, depression, stress, worry about COVID-19 and fear of loneliness during COVID-19 lockdown in Peru: A network analysis approach
Authors: Ventura-León José , López-Jurado Renato , Porturas Emilia , León-Mostacero Irina , Canchanya-Balbin Sherily Edith
Published: September 2022

This study aims to examine the relationships between symptoms of anxiety, depression, stress, worry about COVID-19 and fear of loneliness during COVID-19 lockdown in Peru using network analysis. There were 854 participants aged 18 to 50 years (Mean = 36.54; SD = 9.23); 634 females (74.20%) and 220 males (25.80%), who completed the Generalized Anxiety Disorder Scale (GAD-7), Patient Health Questionnaire (PHQ-9), Perceived Stress Scale (PSS-10), Preoccupation with COVID-19 Contagion (PRE-COVID-19), Brief Scale of Fear of Loneliness (BSFL). A partial unregularized network was estimated through the ggmModSelect function. Expected influence (EI) and bridging EI values were calculated to identify central symptoms and bridging symptoms respectively. The results reveal those two symptoms of depression—stress and anxiety—were the most central symptoms in the network. Depressive symptoms are at the same time the most comorbid and it is shown that there are no differences in the network when compared between those who left home and those who did not leave home during lockdown. Depressive symptoms are concluded to be central and bridging in the network and interconnected with some symptoms of stress and anxiety. These findings may be important to understand the experience of COVID-19 lockdown in Peru.
An online course about cosmetics improves skin care practices and skin health
Authors: Li Yu , Hua Wei , Tang Jie , Xiong Lidan , Li Li
Published: September 2022

Background

The incidence of cosmetics-associated dermatoses is on the rise recently while the awareness and knowledge about proper utilization of cosmetics are insufficient in both the public and specialists due to limited education about cosmetics.

Methods

Our aim was to build and enhance the public's ability to select appropriate cosmetics, manage possible dermatoses and improve skin-care practices and skin health by offering access to medical information via free online courses. Consequently, we launched a massive open online course (MOOC), Appreciation and Analysis of Cosmetics. An online questionnaire was also sent to evaluate the effectiveness of the course.

Results

Nearly 540,000 learners were enrolled in the course since 2014. In the discussion forum, there were 8,383 posts and 73,014 replies in total, where learners were mostly concerned about topics of sun protection, cleansing and proper utilization of cosmetics in some skin diseases. 645 learners answered the questionnaire with 88.84% of the them changed skin care practices and 50.39% reported improvement in skin health. Moreover, participants who completed the course reported better understanding and utilization of cosmetics-related knowledge (p values < 0.05). 72.09% of respondents were willing to recommend this course to others.

Conclusions

Free online public courses are feasible for conducting public health education campaigns related to cosmetics and associated dermatology to lower the incidence of cosmetics-associated dermatoses.
Different stages of chronic kidney disease are associated with physical performance in adults over 60 years
Authors: Song Peiyu , Xu Xinghong , Zhao Yinjiao , Gu Minghong , Chen Xiaoyu , Zhang Hui , Wu Xinze , Yu Chen , Niu Jianying , Ding Wei , Zhang Suhua , Guo Qi
Published: September 2022

Objective:

The purpose of this study was to determine the association between different stages of chronic kidney disease (CKD) and sarcopenia and its components in the Chinese older population.

Methods

The study comprised of 2,213 participants aged ≥ 60 years (1,025 men; mean age: 70.7 years) recruited from Shanghai who were invited to participate in a comprehensive geriatric assessment. Sarcopenia was defined according to the AWGS 2019 consensus update on sarcopenia diagnosis criteria. The glomerular filtration rate (GFR) was estimated using the equation that originated from the CKD-EPI equation, the stages of CKD are classified according to the Kidney Disease—Improving Global Outcomes (KDIGO).

Results

The overall prevalence of sarcopenia was 19.0%, which increased with the severity of CKD. The prevalence of sarcopenia in patients with CKD 3–4 and kidney failure was significantly higher than that in normal and CKD 1–2 (p < 0.05). In logistic regression analysis model, compared with normal and CKD 1 patients, kidney failure was significantly associated with the increased risk of sarcopenia and low grip strength (p < 0.05); CKD 2, CKD 3–4 and kidney failure groups were significantly associated with an increased risk of low walking speed (p < 0.05), respectively; while the association between CKD and muscle mass was not shown.

Conclusions

In our study, only decreased physical performance, as represented by walking speed, was significantly associated with increased CKD severity. This may improve the evidence for the prevention and intervention of sarcopenia in patients with CKD.
Health risk assessment of volatile organic compounds (VOCs) in a refinery in the southwest of Iran using SQRA method
Authors: Khajeh Hoseini Ladan , Jalilzadeh Yengejeh Reza , Mohammadi Rouzbehani Maryam , Sabzalipour Sima
Published: September 2022

Oil industries, such as oil refineries, are important sources of volatile organic compound production. These compounds have significant health effects on human health. In this study, a health risk assessment is carried out on volatile organic compounds (VOCs) in the recovery oil plant (ROP) unit of a refinery in southwest Iran. It was performed using the SQRA1 method including respiratory risk for chronic daily intake (CDI) of VOCs and cancer risk and non-cancer risk indices. Five locations in the area of oil effluents and five locations in the refinery area (control samples) were considered for evaluation. The sampling was done according to the standard NIOSH-1501 and SKC pumps. The gas chromatography/flame ionization detector (GC/FID) method was used to extract VOCs. The cancer slope factor (CSF) and respiratory reference dose (RFC) were calculated in addition to the respiratory risk (CDI). The end result shows that a significant difference was observed between the concentrations of volatile organic compounds in the two groups of air (P < 0.05). The SQRA risk assessment showed that the risk levels of benzene for workers in the pit area were very high (4–5). Health hazard levels were also evaluated as high levels for toluene (2–4) and moderate levels for xylene and paraxylene (1–3). The cancer risk assessment of volatile organic compounds recorded the highest level of cancer risk for benzene in the range of petroleum effluents (>1). Also, a non-cancer risk (HQ) assessment revealed that benzene had a significant health risk in the range of oil pits (2–3). Based on the results, petroleum industries, including refineries, should conduct health risk assessment studies of volatile organic compounds. The units that are directly related to the high level of VOCs should be considered sensitive groups, and their employees should be under special management to reduce the level of exposure to these compounds and other hazardous compounds.