bluuebunny/crossref_metadata_2025 huggingface dataset:
Silences Between Jewishness and Indigeneity in Eduardo Halfon’s Mañana nunca lo hablamos
Authors: Pridgeon Stephanie
Published: July 2018

Este artículo se centra en la obra Mañana nunca lo hablamos (2011) de Eduardo Halfon, argumentando que Halfon aporta una mirada retrospectiva de la violencia de la guerra civil guatemalteca desde una perspectiva judía que se diferencia sustancialmente de la indígena. Sin embargo, este análisis elucida la medida en que la obra de Halfon plantea la posibilidad de una identificación afectiva entre los judíos y los indígenas en el contexto del violento conflicto político. Las conclusiones sostienen que la obra ofrece nuevas posibilidades para pensar la relación entre la etnicidad y la política, una relación conceptual que hasta ahora ha constituido una laguna crítica en los análisis de las producciones culturales judías latinoamericanas.
Gendering the Suicidal Body: Male Translation of Female Death in Javier Marías’ Corazón tan blanco
Authors: Jerónimo Heather
Published: July 2018

Juan, el protagonista de Corazón tan blanco (1992) de Javier Marías, investiga su identidad indagando en los matrimonios de su padre, que están rodeados de secretos y suicidio. Un análisis crítico basado en Volatile Bodies: Toward a Corporeal Feminism (1994) de Elizabeth Grosz muestra cómo el suicidio conecta el cuerpo femenino con el sufrimiento violento, a la vez que sirve como una experiencia liberadora para la validación de la masculinidad. En busca de una narrativa interesada de identidad masculina, Juan se convierte en un traductor voyerista de las inscripciones de suicidio en los cuerpos de mujeres.
Feminine and Failed Suicides in Spanish Cinema
Authors: Ranstrom Claire , Casas Aguilar Anna
Published: July 2018

Este artículo analiza cómo el suicidio frustrado de las protagonistas de ¿Qué he hecho yo para merecer esto!! (Pedro Almodóvar, 1984) y Costa Brava (Family Album) (Marta Balletbò-Coll, 1995) es esencial para entender el lugar de estas dos mujeres en relación con los modelos de género de la España de los 80 y 90 . Argüimos que el acto de suicidio es más que una elección individual, puesto que surge de una serie de coyunturas sociológicas y de género. A su vez, consideramos que el suicidio fallido puede ayudarnos a entender cómo se presenta la autoría y la reescritura del mito de Edipo en las dos películas.
A Trajetória histórica do Comitê Brasileiro de Desenvolvimento de Coleções (CBDC)
Authors: Bueno Katiussa Nunes , Telles Tamara Cecilia Karawejczyk Telles
Published: July 2018

O objetivo desta investigação é analisar o Comitê Brasileiro de Desenvolvimento de Coleções (CBDC), no período de 2010 a 2016, sob a perspectiva das aprendizagens individuais e coletivas evidenciadas nesta trajetória histórica. A metodologia empregada foi coleta de dados por meio de pesquisa documental, entrevistas em profundidade realizadas com os membros da coordenação do CBDC (gestão 2014-2016), que são os sujeitos de pesquisa deste estudo e diário de campo. O método de análise dos dados foi análise de conteúdo, onde tanto os documentos, as entrevistas e o diário de campo compuseram foi realizado com base nas memórias dos membros da coordenação sobre a criação do CBDC e sua trajetória até do ano de 2016. Concluiu-se que o CBDC precisa de um canal de comunicação, armazenagem de documento e informações mais efetivo, pois hoje, por causa da dispersão geográfica entre os membros, há uma dificuldade de contato entre os membros, busca e armazenagem de informação e conhecimento gerado no comitê.
Miradas al paisaje desde la arquitectura alhambreña: realidad patrimonial
Authors: Iturriaga Marta Rodríguez
Published: July 2018

Na cidade palaciana da Alhambra existem vários espaços nazarís que expressam uma clara vocação contemplativa da paisagem. Isso parece surpreendente e incomum em uma era medieval em que os interesses defensivos e o uso produtivo do território prevaleceram sobre qualquer outra consideração em relação a ele. O desejo de olhar e recriar se manifesta não apenas em sua posição, configuração espacial e abundância de cavidades, mas também, em alguns casos, nos testemunhos históricos ou nos textos epigráficos imortalizados na própria arquitetura. Desperta grande interesse, em primeiro lugar, essa vontade de olhar o ambiente de forma descompromissada e aparentemente desinteressada na Idade Média, na qual, teoricamente, a noção de paisagem em território europeu ainda não havia sido iluminada. Trata-se, por outro lado, de uma arquitetura muito antiga e singularmente destinada à atividade contemplativa, sem precedentes claros em termos de sua relação visual intensa com a paisagem circundante. Sua condição patrimonial é inquestionável, entre outras coisas, devido à interdependência desta arquitetura com a paisagem de Granada, a qual procura enquadrar e contemplar. Além disso, a espacialidade alcançada estabeleceu precedentes na maneira de projetar espaços a serem observados, que se mantiveram até hoje. A análise de uma série de espaços selecionados também leva a questionar a linearidade teórica e os postulados simplificadores da história da paisagem, a fim de reabrir o debate devido às peculiaridades históricas, sociais e culturais de cada território.
La Alhambra, un patrimonio de alta eficiencia energética: “Enseñanzas del pasado para la construcción de un futuro sustentable”
Authors: Meneses Brigitte M. Gámez
Published: July 2018

O presente estudo evidencia de forma qualitativa e quantitativa a elevada energia que envolve o conjunto de Palácios da Alhambra, por meio da estreita relação que se observa entre a arquitetura palaciana Nazarí e o cenário, desde a localização, o clima, os aspectos de construção e o material empregado, com aproveitamento e controle da radiação solar, da vegetação, da água e dos ventos, conforme cada estação do ano.
Desenhar a água para ver a Alhambra
Authors: Velázquez Carmen Barrós , Del Campo Francisco J. del Corral
Published: July 2018

A Alhambra e a paisagem cultural que a constitui, com seus fascinantes patrimônios herdados, têm maravilhado a turistas e visitantes, desde sua construção, que buscam captar suas belezas por meio das mais diversas representações artísticas, entre elas o desenho. O correto emprego dos materiais, como a demonstrar verdade e sinceridade em sua construção, torna-se um exemplo de permanente contemporaneidade, graças a sua misteriosa simplicidade. Dentre eles, pode-se destacar a água, estruturante da paisagem, origem dos assentamentos humanos na colina de Sabika e elemento simbólico para os fundadores e, talvez, o mais enigmático e importante material que constitui a paisagem cultural da Alhambra. Entender a água, matéria sutil e poderosa, estreitamente ligada ao “Espaço Alhambra”, será o mesmo que compreender a essência de seus lugares. Por isso, para “ver” uma de suas ferramentas mais simples e eficazes empregadas pelo arquiteto seria o desenho a mão. O simples movimento do lápis por uma folha em branco radiografando a realidade do líquido, transcrevendo sua mensagem, trazendo à luz sua materialidade e seu modo de se relacionar com o contexto, torna-se uma aventura fascinante. “Ver a água com as mãos” seria, desse modo, decifrar os códigos que tornaram possível a paisagem da Alhambra e sua arquitetura. Percebe-se um caminho traçado para a água e seus espaços, onde a palavra aparece somente como um complemento específico de indicação, ou como elemento-chave para se entender algum aspecto concreto. Busca-se escutar a voz da água, compreender sua linguagem e transformar seu modo de ver. Neste olhar, mais do que nunca líquido, intenta-se despertar e provocar no leitor a alegria de continuar observando.
Análise da construção da abóbada anelar do palácio de Carlos
Authors: García Maria Esther Puertas , Vílchez Bernardino Líndez , Sevilla Rafael Gallego , Martín David López
Published: July 2018

A estereotomia da abóbada que constitui o pórtico inferior do pátio do palácio de Carlos V em Granada forma um sistema estrutural auto-estável, porém durante a fase de construção o conjunto seria instável sem o uso de meios auxiliares. As técnicas de pesquisa histórica baseadas em inspeções visuais e a consulta de fontes documentais conjugadas com a lógica estrutural, bem como a otimização de recursos e meios auxiliares permitem chegar a hipóteses sobre o processo construtivo da abóbada. Essas hipóteses podem ser analisadas de forma detalhada e precisa usando modelos numéricos que simulam o comportamento estrutural nos primeiros estágios de construção. Neste artigo, são apresentados modelos de elementos finitos, considerando-se uma análise estática e o comportamento elástico do material, que serve de base para pesquisas históricas para validar as hipóteses levantadas sobre o processo de construção da abóbada toroidal.
Visitas dibujadas: “He dibujado la Alhambra. La recordaré para siempre.”
Authors: Prado Roberto Goycoolea , Fuentealba Jessica
Published: July 2018

No início de uma visita de estudo à Alhambra com alunos da Escola de Arquitectura da Universidade de Alcalá (Outono, 2017), surgiu uma discussão sobre o sentido desse trabalho académico: “Professor, como a Alhambra é tão complexa e o percurso tão rápido, ganhamos tempo se tirarmos fotografias e podemos colocá-las no Instagram, gabando-nos da viagem”. Ainda que pareça anedótico, este pedido colocava três questões chave para a compreensão atual do patrimônio: Que sentido tem visitar o patrimônio? Que diferença há para a sua compreensão desenhá-lo ou fotografá-lo? Que mudanças para a sua visita e compreensão foram introduzidas pelas novas tecnologias? Procurar responder a estas questões, utilizando como caso de estudo a referida visita desenhada à Alhambra, é o objetivo deste artigo. A sua estrutura segue a da visita: a primeira parte dedica-se a responder às perguntas colocadas e a segunda parte apresenta os resultados da experiência académica. As conceptualizações teóricas desenvolvidas no artigo provêm das lições estudadas na disciplina Análise de Formas Arquitetónicas e das investigações dos autores sobre o ensino da arquitetura. Os desenhos, realizados in situ, são publicados sem retoques e os comentários dos alunos correspondem a respostas a um inquérito aos que viajaram a Granada, realizado especificamente para este artigo. Para além de tentar responder às questões colocadas, através da sistematização desta experiência académica procura-se sublinhar o papel do desenho na compreensão e desfrute da arquitetura. Como disse um aluno no final da viagem: “Desenhei a Alhambra. A lembrarei para sempre.”
Una mirada romántica de la Alhambra
Authors: Ruiz Maria José Collado
Published: July 2018

Tão importante quanto o patrimônio construído que compõe a Alhambra e o Generalife é a imagem projetada, ao longo dos séculos, para o resto do mundo a respeito desse complexo arquitetônico. Nela, muito tiveram a observar os viajantes românticos que buscaram um oriente próximo das terras espanholas. Independente de opiniões, mais ou menos corretas, que se expressaram sobre “o espanhol”, o que se torna indiscutível é que, graças a eles, a Alhambra tornou-se conhecida e, por extensão, a cidade de Granada, como um dos destinos universalmente reconhecidos. O modo como atualmente se faz uso dessa imagem projetada e fortemente enraizada no imaginário coletivo é um trabalho que deve partir de uma profunda reflexão multidisciplinar. No entanto, deve-se levar em consideração que do resultado da mesma devem-se obter os conhecimentos e meios para traduzir os diversos olhares a respeito das múltiplas faces do complexo arquitetônico nazarí, envolvendo desde os cidadãos de Granada aos organismos e instituições responsáveis por sua gestão.
Apresentação do Dossiê “O Patrimônio Alhambra: um olhar contemporâneo”
Authors: Líndez Bernardino , González Ana María Sosa
Published: July 2018

Apresentação do Dossiê
Photovoice: A Tool of Reflective Learning to Enhance Students' Speaking Ability
Authors: Husnun Amirah , Wulandari Aprilia , Munawwaroh Atika , Drajati Nur Arifah
Published: July 2018

Students tend to do the same mistakes when performing an oral speaking test. Due to the lack of students' skill in performing speaking, it triggers the researchers to raise this issue so the problem of students in performing speaking could be solved by using reflective learning based on reflective learning strengths. Narrative inquiry is used in this research to elaborate the method, in order to find and analyze the data, photovoice in which more practical is needed by collaborating with SHOWeD analysis. The participants of this study are 15 students who join speaking class of English Education Department. This article provides the findings of the use of reflective learning in the classroom to gain students' speaking ability for college students. In conclusion, the use of reflective learning from lectures to enhance students' speaking ability could be achieved through a certain treatment during the learning and teaching process.Keywords:  Reflective Learning;  Speaking Ability;  Narrative Inquiry;  Photovoice.
Comparative Characteristic of the Maxillary Dental Arch Width Indicators Variability in Men with Different Craniotypes
Authors: Efimova E. Yu.
Published: July 2018

The study of of dental arches morphology is relevant for the improvement and development of new diagnostic and surgical methods. The aim is to make a comparative evaluation of the dental arches width on the upper jaw in mature aged men with physiological occlusion depending on the craniotype. Material and methods. The morphometric parameters of the maxillary dental arches’ width have been studied. The work was performed on 172 preparations of mature aged male skulls with physiological occlusion of teeth. The cranial index was defined as the ratio of the transverse dimension of neurocranium to its longitudinal dimension. When examining dental arches, the main points were set on the medial and distal corners of the tooth crowns from the vestibular and palatal sides. The width of the maxillary dental arch was measured between canines, premolars and molars. Results. The values of the width indices of both the vestibular and palatal sides of the maxillary dental arches at all levels of measurement prevail in the brachycranial type of the skull. The indicators of the maxillary dental arches width in mesocranes are more then those in dolichocranes only at canines and the first premolars. At the second premolars and molars, the difference in the average statistical parameters of the width of the dental arches was not observed. Conclusions. The width of maxillary dental arches in men of mature age depends on craniotype. The new data obtained as a result of the research, supplement and expand the information on the studied parameters, both in theoretical and clinical aspects.
Features of the Fat Component of the Body of Girls Depending on the Constitutional Specifics
Authors: Klochkova S. V. , Pogonchenkova I. V. , Rozhkova E. A. , Alexeeva N. T. , Nikityuk D. B. , Kvaratskheliya A. G.
Published: July 2018

The aim of the study is to obtain quantitative data on the absolute and relative content of the body fat component in girls of different constitutional groups living in the Moscow region. Material and methods. The content of body fat in 722 girls, students, residents of Moscow and Moscow region, representatives of the Slavic ethnos was determined by the method of bioimpedance measurements. Thickness of subcutaneous fat folds was determined by the method of caliperometry. The result of the anthropometric survey identified the presence of asthenic, stenoplastic somatotype (leptosomic constitution), endomorph, mesoplastic somatotypes (mesosomic constitution), athletic, subatellite and europlastic somatotypes (megalosomic constitution). Results. In the studied population, regardless of age, is dominated by girls mesosomic (32.5-39.0%) and megalosomic (31.5-33.3%) groups, several less commonly detected women leptosomic (the 18.6-24.3%) and unspecified (9.1-11.7%) of the constitutions. Thickness of subcutaneous fat folds is dominated by girls mesosomic constitution, and has a minimum value when leptosomic. The absolute content of the fat mass is also smaller when leptosomic constitution. In 20 years the thickness of subcutaneous fat folds, as well as the absolute content of body fat mass in mesosomic, megalosomic and uncertain constitution mainly increases, and the girls leptosomic body almost does not change. Conclusion. The studies have shown a significant impact of the constitutional affiliation of girls on the severity of their fat component, which was proved by both caliper measurement and as a result of bioimpedance studies. Age-related changes in the fat content of the body are also associated with the constitutional type.
Morphofunctional Characteristic of Bone Tissue of Alveolar Processes (Parts) in Conditions of Chronic Odontogenic Infection
Authors: Lebedyantsev V. V. , Shevlyuk N. N. , Lebedyantseva T. V. , Khanov I. A.
Published: July 2018

Assessment of the condition of the alveolar bone is important for the choice of treatment methods for many types of pathology of the dentoalveolar system. The aim of the study was to identify morphofunctional disorders and changes in the optical density of bone tissue of the alveolar process of the maxilla and the alveolar part of the mandible arising from the effects of chronic odontogenic foci of infection. Material and methods. Histological examination of the edges of the alveoli of the removed teeth was carried out in 40 patients with chronic forms of periodontitis. Bony fragments were removed on medical reasons for the prevention of postextraction pain. Decalcification was carried out in Trilon B solution, microtome tissue sections were stained with hematoxylin-eosin. The density of bone tissue was determined on the intraoral radiovisiograms of the removed teeth and intact teeth in 80 persons of the control group. Results. It is established that with chronic forms of periodontitis under the periosteum of the alveolar processes (parts), osteoclastic resorption occurs either in the plane of the bone or with the formation of gauchepic lacunae. The channels of the osteons and the folkman channels widen, and in their circles there are also foci of resorption. Appear pycnosis of osteocytes and extensive areas with empty and dilated osseous lacunae. In the zones of osteolysis, either connective or coarse-fibrous bone tissue is formed. The optical density of bone tissue in patients is significantly less than in individuals with intact teeth. Conclusions. Toxins from chronic odontogenic foci of infection activate the processes of bone resorption of the alveolar process (part) of the jaws and inhibit reparative osteogenesis. The resulting rarefaction of bone tissue leads to a decrease in its optical density.
Age-Related, Ultrasound and Histomorphological Features of Baker's Cyst
Authors: Medvedeva S. Yu. , D'yachkova G. V. , D'yachkov K. A. , Migalkin N. S. , Mal'tseva L. V.
Published: July 2018

The aim of the study was to reveal the features of the morphological structure and ultrasonic signs of Baker's cyst in patients of different ages. Material and methods. The study is based on a sonographic study of 213 patients (mean age 57.2±9.9 years) and 10 children aged 6 to 10 years with a detected Baker cyst. The size of the cyst was studied, its position, relationship with surrounding tissues was examined on sonographic equipment. In addition, parameters were measured, including the thickness of the synovium, the presence of septa and echo-inclusions, the degree of echogenicity of the contents of the cyst. All patients underwent open extirpation of the cyst followed by its morphological analysis. All manipulations were carried out after signing the informed consent of the patient or his legal representatives according to the recommendations "About legal, legislative and ethical norms and requirements in the performance of scientific morphological studies". Preparation of the histological material obtained after the removal of Baker's cyst was carried out according to standard procedures, followed by staining with hemothoxylin-eosin and Van Guzon. The obtained preparations were examined under a light microscope with the possibility of displaying an image on a computer monitor Results. In all adults with an identified Baker cyst, gonarthrosis of varying severity was detected, in contrast to children who had no such joint pathology. Morphological differences in the transformation of the tissues of education in different age groups were also significant. The difference was noted in the form of unexpressed dystrophy of the synovial membrane and the absence of necrotic and degenerative changes in the wall of the cyst in children. Conclusions. This work demonstrated several significant ultrasound and morphological differences in the popliteal cyst in children and adults.
To the Analysis of Correlations Between Clinical Manifestations, Postmortem Pathomorphological and Biochemical Changes in Patients with Polytrauma
Authors: Naletova D. M. , Belyanskiy K. D.
Published: July 2018

The aim of this work was to establish the relationship between the clinical course of polytrauma in persons who died in medical organizations in a relatively remote posttraumatic period with pathomorphological changes in internal organs and postmortal biochemical shifts. Material and methods. The article presents the results of the analysis of 140 cases of death affected with mechanical trauma in the second and third periods of traumatic disease, including the studying of documented material (original medical card hospital patient, expert archival documents), personal conduct expert studies, holding tanatogenesis analysis, evaluation of results of autopsy, postmortem histological and biochemical studies and their comparison with the clinical data described in the medical records. Results. According to the results of the study, it was found that regardless of the terms of hospitalization in the post-traumatic period exceeding 3 days, the results of various “posthumous” studies (the corpse, its organs, tissues and fluids) actually reflect the final traumatic disease of the corresponding period of hospitalization, are not strictly specific, so often do not allow to speak about a specific nosological unit that led to the development of fatal complications. More such studies provide an opportunity to confirm or deny the presence of the described clinical complications premortal period, to determine the tanatogenesis (mechanism of death) and its compliance with the “picture” of dying. Therefore, information from medical documentation about the clinical course of polytrauma, its manifestations and complications, confirmed by in vivo laboratory methods of research and methods of radiation diagnosis, with their proper expert evaluation, are of fundamental diagnostic importance for the scientifically grounded and objective establishment of the main (original) cause of death, developed tanatogenetically significant complications and their relationship with the injury.
Features of the Left Auricle with Various Heart Shape Among Aged Women
Authors: Ovcharenko T. A. , Krugovikhin S. A. , Starchik D. A.
Published: July 2018

The purpose of the study is to identify the frequency of occurrence of different forms of the left auricle with different forms of the heart. Material and methods. For the study, 58 hearts were used, obtained from females 62-74 years old, who died from causes not related to the pathology of the cardiovascular system. Cardiac specimens were examined after fixing them with a 5% formalin solution under constant hydrostatic pressure for 10 days. The measurements were carried out using a caliper. The volume of the left atrial appendage was measured by filling its cavity with water. The shape of the heart was evaluated using a transverse-longitudinal index (TLI,%). Statistical processing of data was carried out using statistical programs Microsoft Excel. Results. Left auricle shape and volume of the are studied depending on the transverse longitudinal index of the heart, which determines the form of this organ. It is noted that the worm-shaped left auricle is more common among aged women with a dolichomorphic heart shape (71,4%); the “cock's comb” shape was determined with a greater frequency in the brachymorphic cardiac form (66.7%); the blade-like left auricle was more often observed in mesomorphic heart form (30.8%). It was established that the hearts with a worm-like shape of the left auricle had significantly more often oval fossa of vertically oriented (52.4%) and round (42.9%) forms. The “cock's comb” form of left auricle was more typical for round (50.0%) and horizontal (31.8%) oval fossa. The blade-shaped left auricle was more often detected (50.0%) with vertically oriented oval fossa. Conclusions. The selection of the three main forms of the left auricle allowed the correlation of this feature to be established with the shape of the heart, determined from the transverse longitudinal index, which makes it possible to classify the form of left auricle into the category of indicators associated with the local constitution of the heart.
Topographic and Anatomical Evaluation of the Effectiveness of Various Methods Reducing the Height of the Inguinal Space Used in Hernioplasty for Inguinal Hernias
Authors: Chernykh A. V. , Zakurdaev E. I. , Zaytseva A. M.
Published: July 2018

Purpose - to evaluate efficiency of different methods reducing height of the inguinal canal with apply in inguinal hernia repair in randomized topographic anatomical study. Material and methods. The randomized topographic anatomical study was performed on 24 unfixed cadavers of male subjects who died at the age of 50.2±6.8 years. The criterion for inclusion in the study was a triangular form of the inguinal canal with a height 2-3 cm. Postoperative cicatrices in the inguinal region, signs of the inguinal hernia and lipoma of the spermatic cord were exclusion criteria. We determined the height of the inguinal canal before and after apply different methods for reducing of this parameter. Results. The dynamic of decrease of the height of the inguinal canal in case apply new method was 30% (from 2.3±0.3 to 1.6±0.2 cm). This result is comparable with the relaxing incision by C. B. MacVay (32%; 2.2±0.4 to 1.5±0.5 cm) and it is larger than the relaxing incisions by R. I. Venglovsky (25%; 2.4±0.2 to 1.8±0.4 cm) and M. M. Ginsberg (14%; 2.2±0.4 to 1.9±0.3 cm). In this case, to apply the performed method compared to relaxing incisions does not destruction of the anterior rectus and appearance of the new hernia portal in the abdominal wall. Conclusion. The developed method of reducing height of the inguinal canal is recommended for approbation in clinical practice because it is effective and safe method.
SPERM QUALITY IN RATS PREDISPOSED TO THE MANIFESTATION OF CATATONIC REACTIONS
Authors: Kleshchev M. A. , Alekhina T. A. , Osadchuk L. V.
Published: July 2018

Catatonia is a psychopathological syndrome displayed as a motor disorder. Catatonia is a sign of many menthal disorders, particularly schizophrenia and depression, with a wide disrtibution in the human population. The GC (“genetic” and “catatonia”) rat strain was obtained from the Wistar rat strain by a long selection (78 generations) for the catatonic type of reaction and is a model of schizophrenic and depressive disorders in humans. It is known that selection for behavior including catatonic reactions results in neuroendocrine, reproductive and morphological changes in animals. However, the influence of selection for a catatonic reaction on the spermatogenic function of testes had not been studied. The aim of this study was to conduct a comparative investigation of sperm quality in rats of the GC and the Wistar strain. The epididymal sperm parameters (sperm count, sperm motility, sperm morphology) were measured, and body, testes and epididymal weight were determined at puberty (50 day of life) and at adulthood (90 day of life). The litter size of the GC and Wistar rats was determined. It was found that adult GC rats had a lower sperm count, sperm motility, testis weight, epydidymal weight and litter size compared to adult Wistar rats. However, at puberty, GC rats had a higher sperm count than the Wistar strain. Interstrain differences in sperm morphology were not found. It has been assumed that the changes of spermatogenic parameters in response to selection for catatonia are caused by changing the ontogenic pattern of testosterone secretion. In conclusion, the hereditary predisposition to catatonic reaction is associated with impaired sperm parameters in adult rats that reduces their chance to reproduction. The GC rat strain can be a perspective model for investigation of the relationship between the hereditary predisposition to catatonia and spermatogenesis
RNAI-MEDIATED SILENCING OF MATRIX METALLOPROTEINASE 1 IN EPIDERMAL KERATINOCYTES INFLUENCES THE BIOLOGICAL EFFECTS OF INTERLEUKIN 17A
Authors: Mogulevtseva J. A. , Mezentsev A. V. , Bruskin S. A.
Published: July 2018

Matrix metalloproteinases (MMPs) are important for the pathogenesis of psoriasis and other autoimmune disorders. In the extracellular matrix, accumulation of proinflammatory cytokines, such as interleukin 17A (IL-17A), leads to induction of several MMPs, including MMP1. MMPs change the composition and other properties of the extracellular matrix. These changes facilitate tissue remodeling and promote the development of psoriatic plaques. The aim of this study was to explore how MMP1 silencing might influence the biological effects of IL-17A on migration and proliferation of human epidermal keratinocytes and the expression of genes involved in their division and differentiation. The experiments were performed with MMP1-deficient and control epidermal keratinocytes, HaCaT-MMP1 and HaCaT-KTR, respectively. Cell proliferation and migration were assessed by comparative analysis of the growth curves and scratch assay, respectively. To quantify cell migration, representative areas of cell cultures were photographed at the indicated time points and compared to each other. Changes in gene expression were analyzed by real-time PCR. The obtained results demonstrated that MMP1 silencing in the cells treated with IL-17A resulted in downregulation of MMP9 and -12, FOSL1, CCNA2, IVL, KRT14 and -17 as well as upregulation of MMP2, CCND1 and LOR. Moreover, MMP1 silencing led to a decrease in cell proliferation and an impairment of cell migration. Thus, MMP1-deficiency in epidermal keratinocytes can be beneficial for psoriasis patients that experience an accumulation of IL-17 in lesional skin. Knocking MMP1 down could influence migration and proliferation of epidermal keratinocytes in vivo, as well as help to control the expression of MMP1, -2, -9 и -12, CCNA2, CCND1, KRT14 and -17 that are crucial for the pathogenesis of psoriasis.
ASSOCIATION BETWEEN POLYMORPHISMS IN GENES ENCODING 2′-5′-OLIGOADENYLATE SYNTHETASES AND THE HUMORAL IMMUNE RESPONSE UPON VACCINATION AGAINST TICK-BORNE ENCEPHALITIS
Authors: Yudin N. S. , Igoshin A. V. , Lutova S. L. , Gon Ya. , Voevoda M. I. , Belyavskaya V. A.
Published: July 2018

Vaccination forms active immunity and represents an effective way of preventing tick-borne encephalitis (TBE). However, excessive vaccination is unjustified in terms of economics and medical ethics. One of the individualized approaches to vaccines is the selection of vaccine doses depending on the expected levels of immune response. Therefore, there is a need for new methods for assessing potential human immune responses prior to vaccination. The aim of this study was to determine possible association between single nucleotide polymorphisms (SNPs) located within OAS2 and OAS3 genes, which have been previously associated with the development of severe forms of TBE, and the formation of antibodies and cytokines upon vaccination against TBE. The study involved 97 volunteers of both sexes who had not previously been vaccinated against TBE and had no contact with ticks. Venous blood samples were collected one month after vaccination against TBE using the EnceVir vaccine. Levels of specific IgG antibodies against tick-borne encephalitis virus and interleukin 4 (IL-4) were analyzed. Genomic DNA samples were genotyped for the SNPs rs2285932, rs2072136, rs1293762, rs15895 and rs1732778 in genes encoding 2’-5’-oligoadenylate synthetases OAS2 and OAS3. Antibody production in response to vaccine administration was significantly associated with SNP rs1732778 in the regulatory region of the OAS2 gene. This indicator was significantly higher in people with heterozygous genotypes G/A as compared to people with homozygous genotypes G/G and A/A. Carriers of the A allele (G/A or A/A genotypes) of the same SNP had reduced IL-4 levels as compared to the homozygous G/G individuals. Thus, the data obtained indicate that SNP rs1732778 in the regulatory region of the OAS2 gene correlates with the formation of antiviral IgG antibodies and changes in IL-4 levels upon vaccination. Evidently, the genetic polymorphism in OAS2 gene should be considered when performing individualized TBE vaccinations.
INTERSTRAIN DIFFERENCES IN EMOTIONAL AND WEIGHT INDICES IN GC RATS WITH CATATONIC RESPONSE AND WISTAR RATS
Authors: Alekhina T. A. , Kozhemjakina R. V.
Published: July 2018

In selecting rats for behavior, we observe a direct natural effect and affect the nonspecific stress function. In this process, new behavioral phenotypes appear in the strain under selection. They differ from the selected forms in the selection criterion. In the GC strain, a large proportion of the so-called nervous rats emerge. The criterion presumes the selection for the long cataleptic freezing character, whereas the nervous rats display elevated motor excitement: running, jumping, and vocalization. The main purpose of our study was to assess phenotypic indices in GC rats (abbreviated from genetic and catatonia) and recognize principal components of variability for emotional and weight indices. Rats of the ancestral Wistar population were taken as control. The following indices were measured: time of cataleptic freezing, excitement level, blood pressure, acoustic startle response, seizure  activity, and weights of the heart, kidneys, adrenals, and spleen. Multivariate analysis methods were applied: factor analysis and principal component analysis. We confirmed the inclination of GC rats of the generation studied to freezing in quiet surrounding and after a strong acoustic sti - mulus. More pronounced startle responses,  moderate hypertension, and larger weights of the heart and adrenals were noted. Two principal variability components were recognized: startle amplitude (PC1) and morphofunctional variability (PC2). The figure shows different locations of Wistar and GC individuals in principal component coordinates. The principal component method confirmed the genetic relationship between the startle and nervousness responses. It was shown that in PC2 the indices of heart, kidney, adrenal, and spleen weight exert negative effects, whereas the effects of startle and nervousness were positive. In the same component, an increase in the startle and nervousness responses positively correlates with the relative weights of the heart and adrenals. Differences in the directions of the contributions to the second component of morphofunctional variability are discussed.
MONITORING OF Aegilops L. LOCAL SPECIES GENETIC DIVERSITY OF KAZAKHSTAN’S FLORA
Authors: Urazaliev R. , Yessimbekova M. , Mukin K. , Chirkin A. , Ismagulova G.
Published: July 2018

Cereal Crop Wild Relatives (CWR) are a very  important gene pool for cereal/wheat improvement. New genes for resistance to diseases and pests are urgently needed to avoid using pesticides and to raise adaptivity to the environmental stresses caused by global climate change. In this regard, the study is aimed at ex situ conservation of Aegilops L. genus local ecotypes’ genetic diversity, which is very relevant and promising for breeding. In order to establish breeding utility and form an ex situ collection reflecting the intra- and inter-specific diversity, the phenotypic screening of Kazakhstan’s local populations of Aegilops L. genus (Ae. cylindrica, Ae. tauschii, Ae. triuncialis and Ae. crassa) was conducted on the basis of multiple indicators. For the first time molecular-genetic analysis of 50 representatives of Aegilops L. genus from Kazakhstan’s flora was performed. The microsatellite analysis with the use of 11 EST-SSR markers revealed eight of them to be most effective. For each marker, allele frequency and average heterozygosity was calculated. For the most informative markers the presence of 5 and 6 respective allelic variations was found. A bank of genomic DNA was created and kept in ex situ storage (–70 °С, long-term) in the IMBB of the MES of RK.
Acyl-CoA type 5 gene polymorphism and inappropriate body mass occurrence related to waist circumference and insulin resistance index among the population living in southern Poland
Authors: Grzeszczak Wladyslaw , Zdebska Magdalena , Szywacz Wioletta , Matuszny Grzegorz , Abouda Alicja , Szweda Nikola , Gola Mateusz , Śnit Mirosław
Published: July 2018

Wstęp

Zaburzenia przemian lipidów i związana z nimi otyłość to problem coraz częściej dotykający ludzi w krajach wysoko rozwiniętych. Syntetaza acylo-CoA typu 5 (ACSL5) jest ważnym enzymem metabolizmu lipidów, biorącym udział w aktywacji kwasów tłuszczowych. Prawidłowe funkcjonowanie tego enzymu zapewnia substraty zarówno dla lipogenezy, jak i oksydacji kwasów tłuszczowych, stąd określenie związku między polimorfizmem genu dla ACSL a kształtowaniem otyłości stanowi istotny problem badawczy.

Cel pracy

Celem pracy było wykazanie zależności między nieprawidłową masą ciała oraz wartością wskaźnika HOMA-IR (homeostasis model assessment) a występowaniem polimorfizmu genu syntetazy acylo-CoA izoformy 5.

Materiał i metody

Przebadano łącznie 506 pacjentów, u których za pomocą sond specyficznie wiążących się z DNA matrycy oznaczono polimorfizm ACSL5 rs2419621.

Wyniki

Za pomocą testu statystycznego Hardy’ego-Weinberga wykazano, że proporcje genotypów w populacji są zachowane. Wśród pacjentów stanowiących próbę badawczą wyróżniono 177 osób o prawidłowej masie ciała oraz 330 osób z nieprawidłową wartością indeksu BMI.

Wnioski

Wykazano brak zmiennych różnic statystycznych w rozkładzie genotypów polimorfizmu genu syntetazy acylo-CoA izoformy 5. Wyniki przeprowadzonego badania nie pozwalają wykazać zależności między polimorfizmem genu dla ACSL5 a kształtowaniem otyłości.
Collaborative Argumentation As A Learning Strategy To Improve Student Performance In Engineering Statics: A Pilot Study
Authors: Foutz Timothy L.
Published: July 2018

Educators have used argumentation to help students understand mathematical ideas which often appear abstract to the novice learner.  A preliminary investigation was conducted to determine if collaborative argumentation is a strategy that can improve the student’s conceptual understanding of the topics taught in the engineering course commonly titled Statics.  The academic performance of students enrolled in a traditional problems-solving session was compared to the academic performance of students enrolled in a problem-solving session where collaborative argumentation was used. Results suggest that argumentation improved student performance as measured by grades associated with one-hour long exams, although student written responses on a course evaluation survey responses indicate that students did not believe argumentation was a learning strategy was effective.
Engage Engineering Students In Homework: Attribution Of Low Completion And Suggestions For Interventions
Authors: Li Wenshu , Bennett Richard M. , Olsen Taimi , McCord Rachel
Published: July 2018

Homework is an important out-of-class activity, crucial to student success in engineering courses. However, in a first-semester freshman engineering course, approximately one-fourth of students were completing less than 80% of the homework.  The purpose of this study was to examine students’ attribution of their low completion of homework and suggest corresponding interventions to help students with different attribution types. A qualitative approach was applied using semi-structured interviews for data collection. The interviewees were students who were on track to complete less than 80% of the homework. Students in the study attributed their low rates of completion to multiple factors. We coded and summarized students’ attributions of homework incompletion according to Weiner’s attribution theory and suggested corresponding interventions for students with different attribution types. Results show that most students attributed their failure to complete their homework to external reasons rather than internal reasons. A large portion of student’s attributions for low homework completion was due to poor time management skills.  Some students attributed low homework completion to unstable factors such as illness, transition, or adjustment problems. A small portion attributed low homework completion to uncontrollable reasons, such as sickness and homework difficulty. Students’ reasons for homework incompletion varied across the three dimensions of Weiner’s attribution theory suggesting that a variety of intervention techniques is required.  In addition to use of widely adopted interventions such as first year seminars, tutoring, and tutorial sessions, intervention techniques based on attribution theory may be necessary to employ, to help students avoid negative emotional and behavioral consequences of homework incompletion.
Toward Understanding The Role Of Web 2.0 Technology In Self-Directed Learning And Job Performance
Authors: Caruso Shirley J.
Published: July 2018

This paper serves as an exploration and thick description of job performance outcomes based upon the manner in which self-directed learning activities of employees are conducted, mediated by the use of Web 2.0 technologies in organizational settings. It provides a collective view of the role that Web 2.0 technology plays in self-directed workplace learning and job performance outcomes to benefit employees, organizations, and human resource development professionals. To expand further the knowledge base of adult learning and self-directed learning activities, this paper places its focus on the role of Web 2.0 technology in adult learners’ engagement in self-directed learning. Part of the discussion focuses on learners’ preferences in relation to the emergence of Web 2.0 technology. This discussion of learner preferences explores learning environments that participants engaged in and the motivation behind their engagement. This paper contributes to the field of human resource development by providing a new lens that views the role of Web 2.0 technology in self-directed learning and job performance within an organizational setting, thereby enabling its integration into a blended-learning site. A practical application resulting from this paper is to provide insight to human resource development professionals into best practices and recommendations for the adoption and application of Web 2.0 technology.
An Examination Of The Roles Of State School Psychology Consultants
Authors: Fan Chung-Hau , Gallup Jennifer L. , Wu I-Chen , Ford Jeremy W.
Published: July 2018

With the increasing visibility of state school psychology consultants (SSPCs) across the nation, there is a pressing need to understand their roles and functions relative to serving their stakeholders. In addition, it is unclear whether current SSPC job responsibilities are aligned with the National Association of School Psychologists’ (NASP) practice model, which can help ensure the quality of school psychological service delivery. A qualitative case study design was conducted with interviews to examine the job responsibilities of SSPCs (e.g., provision of consultation, policy guidance, professional development, coordination of professional resources and services). The qualitative analysis revealed three main themes: (a) service provision, (b) collaborative roles and efforts, and (c) systems improvement across the state, which were aligned with different levels of domains in the NASP practice model. The findings can help inform the roles and responsibilities of SSPCs and the development of new SSPC functions. Implications for conceptualization of the SSPC initiative in relation to the NASP practice model for future practice are discussed.
Enhancing The Quality Of University Career Services In Taiwan: Perceptions Of University Alumni
Authors: Ho Hsuan-Fu , Huang Wei-Ting , Hu Tien-Ling
Published: July 2018

An adequate supply of a high quality labor force is crucial for national economic and social well-being; consequently, nations worldwide have placed significant emphasis on university graduate employability. Nonetheless, in Taiwan, a mismatch between knowledge acquired in universities and competences required by the job market has dramatically encumbered the supply of a high quality labor force. Thus, this research endeavored to determine the major career services that should be offered in higher educational institutions to alleviate the aforementioned human resource problems.The analytic hierarchy process was adopted as the major instrument for calculating the relative importance of each career service task, and 169 university alumni working in four major career fields participated in this research. The results indicated that participants from different career fields and who graduated from different colleges at different times have very different opinions of job service requests; therefore, universities should seriously consider the differences among students and provide the necessary services for each student in line with his/her particular requests. Moreover, although almost all participants agreed that sharpening students’ job-search and interview skills was crucial in assisting students to find their first jobs, this service was extremely insufficient in universities, and universities thus have to place particular emphasis on this task in the future.
Using Data To Enhance Decision Making: Graduation Initiative 2025
Authors: McMahan Shari , Lopez-Wagner Muriel C.
Published: July 2018

The California State University launched its Graduation Initiative 2025 in January 2015 with a clear goal to increase graduation rates for our 475,000 students across all 23 campuses.  The Graduation Initiative 2025 will add 100,000 more baccalaureate degree-educated citizens to California over the next ten years and begin to meet workforce demands. Increasing graduation rates, particularly for first-generation students, requires a strategic, data-driven approach. California State University, San Bernardino (CSUSB) faces particular challenges as 81% of our undergraduate population are first-generation college students, 63% receive Pell Grant, and 56% of incoming first-year students require some form of developmental coursework in English, math, or both.  Data-driven decision-making must be used to focus graduation efforts.  CSUSB organizes data regarding college readiness, and enrollment characteristics as preparedness have a direct influence on time to degree.  Data on persistence and progress towards the degree are also important to track when examining graduation rates as it helps identify areas to improve.  Finally, data on completion and post-graduation are indicators to track the progress of the initiative and meeting workforce demands.