bluuebunny/crossref_metadata_2025 huggingface dataset:
High throughput detection and genetic epidemiology of SARS-CoV-2 using COVIDSeq next-generation sequencing
Authors: Bhoyar Rahul C. , Jain Abhinav , Sehgal Paras , Divakar Mohit Kumar , Sharma Disha , Imran Mohamed , Jolly Bani , Ranjan Gyan , Rophina Mercy , Sharma Sumit , Siwach Sanjay , Pandhare Kavita , Sahoo Swayamprabha , Sahoo Maheswata , Nayak Ananya , Mohanty Jatindra Nath , Das Jayashankar , Bhandari Sudhir , Mathur Sandeep K. , Kumar Anshul , Sahlot Rahul , Rojarani Pallavali , Lakshmi Juturu Vijaya , Surekha Avileli , Sekhar Pulala Chandra , Mahajan Shelly , Masih Shet , Singh Pawan , Kumar Vipin , Jose Blessy , Mahajan Vidur , Gupta Vivek , Gupta Rakesh , Arumugam Prabhakar , Singh Anjali , Nandy Ananya , P. V. Ragavendran , Jha Rakesh Mohan , Kumari Anupama , Gandotra Sheetal , Rao Vivek , Faruq Mohammed , Kumar Sanjeev , Reshma G. Betsy , Varma G. Narendra , Roy Shuvra Shekhar , Sengupta Antara , Chattopadhyay Sabyasachi , Singhal Khushboo , Pradhan Shalini , Jha Diksha , Naushin Salwa , Wadhwa Saruchi , Tyagi Nishu , Poojary Mukta , Scaria Vinod , Sivasubbu Sridhar
Published: February 2021

The rapid emergence of coronavirus disease 2019 (COVID-19) as a global pandemic affecting millions of individuals globally has necessitated sensitive and high-throughput approaches for the diagnosis, surveillance, and determining the genetic epidemiology of SARS-CoV-2. In the present study, we used the COVIDSeq protocol, which involves multiplex-PCR, barcoding, and sequencing of samples for high-throughput detection and deciphering the genetic epidemiology of SARS-CoV-2. We used the approach on 752 clinical samples in duplicates, amounting to a total of 1536 samples which could be sequenced on a single S4 sequencing flow cell on NovaSeq 6000. Our analysis suggests a high concordance between technical duplicates and a high concordance of detection of SARS-CoV-2 between the COVIDSeq as well as RT-PCR approaches. An in-depth analysis revealed a total of six samples in which COVIDSeq detected SARS-CoV-2 in high confidence which were negative in RT-PCR. Additionally, the assay could detect SARS-CoV-2 in 21 samples and 16 samples which were classified inconclusive and pan-sarbeco positive respectively suggesting that COVIDSeq could be used as a confirmatory test. The sequencing approach also enabled insights into the evolution and genetic epidemiology of the SARS-CoV-2 samples. The samples were classified into a total of 3 clades. This study reports two lineages B.1.112 and B.1.99 for the first time in India. This study also revealed 1,143 unique single nucleotide variants and added a total of 73 novel variants identified for the first time. To the best of our knowledge, this is the first report of the COVIDSeq approach for detection and genetic epidemiology of SARS-CoV-2. Our analysis suggests that COVIDSeq could be a potential high sensitivity assay for the detection of SARS-CoV-2, with an additional advantage of enabling the genetic epidemiology of SARS-CoV-2.
Integration of transcriptomic and proteomic analyses for finger millet [Eleusine coracana (L.) Gaertn.] in response to drought stress
Authors: Li Jiguang , Wang Yanlan , Wang Liqun , Zhu Jianyu , Deng Jing , Tang Rui , Chen Guanghui
Published: February 2021

Drought is one of the most significant abiotic stresses that affects the growth and productivity of crops worldwide. Finger millet [Eleusine coracana (L.) Gaertn.] is a C4 crop with high nutritional value and drought tolerance. However, the drought stress tolerance genetic mechanism of finger millet is largely unknown. In this study, transcriptomic (RNA-seq) and proteomic (iTRAQ) technologies were combined to investigate the finger millet samples treated with drought at different stages to determine drought response mechanism. A total of 80,602 differentially expressed genes (DEGs) and 3,009 differentially expressed proteins (DEPs) were identified in the transcriptomic and proteomic levels, respectively. An integrated analysis, which combined transcriptome and proteome data, revealed the presence of 1,305 DEPs were matched with the corresponding DEGs (named associated DEGs-DEPs) when comparing the control to samples which were treated with 19 days of drought (N1-N2 comparison group), 1,093 DEGs-DEPs between control and samples which underwent rehydration treatment for 36 hours (N1-N3 comparison group) and 607 DEGs-DEPs between samples which were treated with drought for 19 days and samples which underwent rehydration treatment for 36 hours (N2-N3 comparison group). Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis identified 80 DEGs-DEPs in the N1-N2 comparison group, 49 DEGs-DEPs in the N1-N3 comparison group, and 59 DEGs-DEPs in the N2-N3 comparison group, which were associated with drought stress. The DEGs-DEPs which were drought tolerance-related were enriched in hydrolase activity, glycosyl bond formation, oxidoreductase activity, carbohydrate binding and biosynthesis of unsaturated fatty acids. Co-expression network analysis revealed two candidate DEGs-DEPs which were found to be centrally involved in drought stress response. These results suggested that the coordination of the DEGs-DEPs was essential to the enhanced drought tolerance response in the finger millet.
SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development
Authors: Murgolo Nicholas , Therien Alex G. , Howell Bonnie , Klein Daniel , Koeplinger Kenneth , Lieberman Linda A. , Adam Gregory C. , Flynn Jessica , McKenna Philip , Swaminathan Gokul , Hazuda Daria J. , Olsen David B.
Published: February 2021

Since the initial report of the novel Coronavirus Disease 2019 (COVID-19) emanating from Wuhan, China, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally. While the effects of SARS-CoV-2 infection are not completely understood, there appears to be a wide spectrum of disease ranging from mild symptoms to severe respiratory distress, hospitalization, and mortality. There are no Food and Drug Administration (FDA)-approved treatments for COVID-19 aside from remdesivir; early efforts to identify efficacious therapeutics for COVID-19 have mainly focused on drug repurposing screens to identify compounds with antiviral activity against SARS-CoV-2 in cellular infection systems. These screens have yielded intriguing hits, but the use of nonhuman immortalized cell lines derived from non-pulmonary or gastrointestinal origins poses any number of questions in predicting the physiological and pathological relevance of these potential interventions. While our knowledge of this novel virus continues to evolve, our current understanding of the key molecular and cellular interactions involved in SARS-CoV-2 infection is discussed in order to provide a framework for developing the most appropriate in vitro toolbox to support current and future drug discovery efforts.
Makromolekulás kolloidokból felépülő hatóanyag hordozó rendszerek tervezése
Authors: Varga Norbert
Published: February 2021

Kutatócsoportunkban már néhány éve kiemelt figyelmet kap főként szérum fehérje alapú hatóanyag hordozó kolloid részecskék előállítása, ahol idegtudományi kutatásokban releváns, neuroaktív hatással rendelkező vegyületek vér-agy gáton való transzportjának megvalósítása a cél. Ezen kutatásokhoz kapcsolódtam 2017. őszén, ahol egy újonnan elnyert GINOP-2.3.2 pályázat keretein belül, kiemelt feladatom volt új típusú, főként polimer és poliszacharid alapú hatóanyaghordozó rendszerek tervezése és reprodukálható szintézisek kidolgozása. Célul tűztük ki főként PLA, PLGA és hialuronsav (HyA) alapú makromolekulás kolloidokból felépülő hordozó rendszerek kialakítását, ahol tanulmányozni kívántuk a hordozó rendszerek hidrofilitásának, szerkezetének, felületi töltésének a modellként alkalmazott hidrofil vagy hidrofób, aromás, vagy csak alifás csoportokat tartalmazó, töltéssel rendelkező vagy semleges kismolekulák kapszulázási hatékonyságára gyakorolt hatását. Meghatározni kívántuk, hogy a képződő részecskék méretét, szerkezetét, morfológiáját milyen kísérleti tényezők befolyásolják. Ahol arra lehetőség adódott, a hatóanyag felszabadulás kinetikáját is tanulmányozni kívántuk.
Vállalati stratégiák, konfigurációk Magyarországon 1992 és 2010 között - 2. rész (Corporate strategies, configurations in Hungary between 1992 and 2010 - Part 2)
Authors: Szabó Zsolt Roland
Published: February 2021

A vállalatok teljesítménycéljai az elmúlt két évtizedben alapvetően hét különböző dimenzió mentén jelentek meg. Ennek alapján izgalmas kérdés, hogy milyen eszközökkel azonosíthatjuk a kirajzolódó stratégiai mintázatokat, mely vállalati stratégiák, konfigurációk voltak különösen versenyképesek, és miként érhető el a kiemelkedő vállalati teljesítmény? Ezekre a kérdésekre válaszol a cikk. A tanulmány első része a Vezetéstudomány ez évi 6. számában jelent meg.
Fogalmi kapaszkodók a kkv-k innovációs gyakorlatában
Authors: Hoffer Ilona , Katona Viktória
Published: February 2021

A szerzők cikkükben a hazai innovációfinanszírozási szabályozás alapfogalmi, terminológiai vizsgálatára vonatkozó kutatásaik fő megállapításait mutatják be. Azokat az eredményeket, amelyek elsősorban a témakör vonatkozó alapismereteinek összegyűjtésére, rendszerezésére irányultak. Vagyis céljuk, az innováció és kapcsolódó fogalmainak áttekintése az alkalmazás szempontjából. Kutatásuk tisztázó jellege iránytűként szolgálhat a gazdasági szakemberek számára, valamint figyelemfelhívásként a jogszabályalkotók felé.
A nettó jelenérték gazdasági tartalma és rangsorképzésre való alkalmassága
Authors: Illés Mária
Published: February 2021

A nettó jelenérték egyaránt jól ismert kategóriája a gazdálkodástani irodalomnak és a gazdálkodási gyakorlatnak. A tartalmi alapkérdések mindmáig tisztázatlanok. A tanulmány a tipikus hozadéksorú beruházásokra vonatkozóan definiálja a nettó jelenérték gazdasági tartalmát, majd bizonyítja, hogy a meghatározás helyes. Továbbá rámutat, hogy a döntési változatok összehasonlíthatósága szempontjából a nettó jelenérték három összefüggésben tartalmaz torzítást. Ezeknek a torzításoknak a szisztematikus kiküszöbölése révén a nettó jelenérték egyfajta rátává, méghozzá a belső kamatláb és a kalkulatív kamatláb egyfajta különbségévé alakul át. E rátakülönbség szerinti rangsor megegyezik a belső kamatláb szerinti rangsorral.
A beruházásgazdaságossági számítások gyakorlatban alkalmazott módszerei
Authors: Szűcsné Markovics Klára
Published: February 2021

A cikk 23 ország és a közép-kelet-európai régió vállalatai körében gyakran alkalmazott beruházásgazdaságossági módszerekről nyújt átfogó szakirodalmi áttekintést a vonatkozó külföldi kutatási eredmények feldolgozásával. A feldolgozott tanulmányok alapján két fontos megállapítás tehető az alkalmazott módszerekkel kapcsolatosan: az egyik, hogy az ország földrajzi elhelyezkedésétől függetlenül a vállalatok többsége kiszámítja a statikus megtérülési idő mutatóját, igaz, az nem dönthető el egyértelműen, hogy elsődleges vagy másodlagos mutatóként használják-e ezt a mutatószámot a beruházási döntéseknél. A másik, hogy az időtényezőt figyelembe vevő módszerek közül a nettójelenérték-számítás és a belsőkamatláb-keresés a két leggyakrabban alkalmazott módszer, a jövedelmezőségi index használata egy-két kivételtől eltekintve nem jellemző.
Tobacco smoking in non-psychotic patients with suicidal ideation
Authors: Zinchuk Mikhail , Kustov Georgii , Beghi Massimiliano , Pashnin Evgenii , Yakovlev Alexander , Avedisova Alla , Guekht Alla
Published: February 2021

Recent studies have found a higher incidence of suicidal ideation/plan/attempt and non-suicidal self-injurious behavior among smokers (Poorolajal et al., 2016; Marin et al., 2020). People with mental health problems have been shown to be one of the most smoking populations (Szatkowski et al, 2015). At the same time, the presence of a mental disorder is an independent predictor of the occurrence of suicidal ideation (Klonsky et al, 2017). An important question about the impact of nicotine consumption on the course of self-Injurious thoughts and behaviors in persons with non-psychotic mental disorders remains unclear.

The aim of the study is to evaluate the influence of tobacco smoking (TS) on the risk of lifetime suicidal plan (SP), attempt (SA) and nonsuicidal self-injury (NSSI) in patients with nonpsychotic mental disorders (NPMD) and suicidal ideation (SI).

Four hundred and 78 consecutive patients with NPMD and SI were included. All patients were evaluated by a psychiatrist, underwent Self-Injurious Thoughts and Behaviors Interview (SITBI) as well as semi-structured interview designed to gather information on demographic and biographical features. Mann-Whitney, chi-square test and stepwise logistic regression were used as statistical methods.

The mean age of the sample was 28 (11.46) and most of the patients were female 417 (97.2%). Lifetime TS was reported by 324 (67.8%) patients. We found no differences between smokers and non-smokers in age, gender, educational and occupational statuses, as well as the diagnoses of mental disorders and their number (Tab.1). SP, SA and NSSI were significantly more common in patients with lifetime tobacco smoking history. No significant differences were found in age of onset of self-injurious thoughts and behavior, and total number of SP, SA and NSSI between lifetime smokers and non-smokers (Tab. 2) Stepwise logistic regression analysis revealed an association of lifetime TS with lifetime SA and NSSI, but not with SP (Tab: 3).

In consistence with previous studies (Sankaranarayanan et al., 2015; Marin et al., 2020), our results suggested that lifetime tobacco smoking is strongly associated with an increased risk of suicidal and non-suicidal self-injurious behavior. Moreover, we showed suggested that tobacco smoking involved in transition from ideation to action. It is proposed that smoking may increase the risk of suicide through a biological pathway - decreasing the activity of the serotonergic system of hippocampus, reduce brain serotonin function and activate of the hypothalamo-pituitary-adrenal axis (HPA). Thus, nicotine may be able to activate the attenuated responsiveness of the HPA axis to psychological stress (Poorolajal et al, 2016).

History of lifetime TS in patients with NPMD and SI is associated with an increased risk of suicidal and nonsuicidal self-injurious behavior.
Vagus Nerve Stimulation in Treatment-Resistant Depression: Long-term Clinical Outcomes
Authors: Rosson Stella , Bresolin Nicola , d’Avella Domenico , Denaro Luca , Landi Alessandro , Caiolo Stefano , Lussignoli Marialaura , Toffanin Tommaso , Pigato Giorgio
Published: February 2021

I
ntroduction

Vagus nerve stimulation (VNS) is a neuromodulation technique approved for Treatment-Resistant Depression (TRD).Evidence regarding its long-term efficacy and safety is still scarce.

Objectives

To descriptively report a case series of 3 patients undergoing adjunctive VNS for TRD with an over 10-year follow-up.

Methods

We investigated outcomes of clinical interest in patients with ongoing VNS for at least 10 years after the device implantation. They had participated in a larger single-arm interventional study conducted at the University Hospital of Padua. They were diagnosed with chronic unipolar (1), recurrent unipolar (1), and bipolar (1) TRD.

Results

Our 3 cases had an average 14-year history of psychiatric disease before surgery. Afterward, all subjects achieved clinical remission within two years. 2 patients experienced relapses within the first 4 years of treatment (respectively, 1 and 2 episodes). The other case showed a recurrent trend of brief relapses every two years. Only 1 individual needed to be admitted to the psychiatric unit once. None of them committed suicidal attempts. Prescription of antidepressants remained almost unchanged after the first two years. 2 individuals improved and 1 maintained their working position. Common adverse events were voice alteration (3/3), neck pain (2/3), and cough (2/3).

Conclusions

Very few cases of 10-year VNS for TRD have been reported so far. For our subjects, VNS was most likely to have a major impact on the clinical course of the disease. This treatment can be a safe and effective adjunctive intervention in a subgroup of patients with TRD.
Reserva cognitiva, compensación y potencial de aprendizaje: relación entre medidas
Authors: Juan Carlos Meléndez Moral , Alicia Sales Galán , Teresa Mayordomo Rodríguez
Published: February 2021

Frente a las pérdidas cognitivas que pueden acompañar al envejecimiento, surgen tres conceptos: la
compensación, la reserva cognitiva y el potencial de aprendizaje, los cuales se presentan como formas
adaptativas de frenar el deterioro. El objetivo de esta investigación es analizar las características de sus
medidas, estudiar la relación entre éstas variables y comprobar la existencia de diferencias en el potencial de
aprendizaje y las estrategias de compensación en función de dos grupos: alta y baja reserva cognitiva. En el
estudio participaron 96 sujetos, con una media de edad de 73,23, los cuales fueron evaluados con una extensa
batería de pruebas neuropsicológicas. Se confirmó la estructura del Memory Compensation Questionnaire
(MCQ), se desarrollo una medida de reserva cognitiva y se estimo el potencial de aprendizaje de los
participantes. Se obtuvieron relaciones significativas y positivas entre las medidas estudiadas, y se hallaron
diferencias entre los grupos de alta y baja reserva. Se concluye que existe relación entre las variables, en
base a las medidas utilizadas y que los sujetos con alta reserva cognitiva aplican estrategias alternativas
y eficaces de compensación que les proporciona un mayor potencial de aprendizaje permitiendo una mayor
capacidad de adaptación.
Ksiądz Zdzisław Grzegorski — ojciec polskiej homiletyki kontekstualnej
Authors: Kalbarczyk Adam
Published: February 2021

The article reminds and introduces the work of Zdzisław Grzegorski (1930–2012), a theologian from Poznań, a lecturer of homiletics and the editor of the “Biblioteka Kaznodziejska” (Preachers’ Library), called the father of the Polish school of contextual homiletics. The contextual homiletics, which he created and popularized in numerous publications, deals with the relationship of the forms of religious messages to other forms of communication and makes the effectiveness of proclaiming the word of God relevant to communicating. The service of the word creates a peculiar channel of information, consisting of such elements as: theological awareness, disposition of the preacher, the attitude of the recipient, the closer and further context, the language. The communication act on the pulpit has various functions: cognitive, conative, phatic and prophetic. The preacher should check the functioning of the communication channel through the theological and postulative observation.

Grzegorski’s concept was developed in a few national symposia and conferences. It had a significant impact on the contemporary Polish homiletic reflection. The communication and contex- tual orientation can be seen in several works of Polish preachers. Nevertheless, Grzegorski’s work demands further development and popularization, so that the contextual understanding and practice of communicating the word of God has been adopted in the Church.
Symboliczny wymiar przestrzeni sakralnej w otoczeniu sanktuariów maryjnych w krajobrazie Warmii i Mazur
Authors: Połucha Iwona
Published: February 2021

Przestrzeń sakralna jest dopeniełniem obiektów kultu, a jej zagospodarowanie ułatwia odczytywanie i rozumienie przesłania religijnego. W artykule poruszono aspekty aranżacji otoczenia kościołów powszechnie występujących w krajobrazie warmińsko-mazurskim, przy których warto kontynuować uwarunkowaną historycznie symboliką komponentów zieleni. Zasadność kreowania przestrzeni sakralnej jako miejsc medytacji i przey religijnych ukazano przez pryzmat znaczenia religijnego i wartości wybranych obiektów kultu maryjnego, do których należą sanktuaria na Warmii i Mazurach.
“The Ripping Apart of Silence”
Authors: Lentjes Rebecca , Alterman Amy E. , Arey Whitney
Published: February 2021

This article explores the gendered sound world of anti-abortion protests outside U.S. abortion clinics. These clinics are spaces of dissent where, on a daily basis, protesters congregate to vocalize their opposition to abortion. We employ the concept of sonic patriarchy, the sonic counterpart to the male gaze, to explore how anti-abortion protesting dominates the aural space surrounding abortion clinics and is used as a vehicle for controlling gendered bodies. Protesters use megaphones, speakers, and yelling to infuse the soundscape of the abortion clinic with an overwhelming cacophony that people must enter to receive care. This article reconceptualizes how we think about sound and violence by emphasizing how the everyday sounds of anti-abortion protesting are perceived and experienced as violence by people seeking abortion services. This domination of the sound world engenders a form of nonconsensual listening, in which it becomes difficult, if not impossible, to ignore the sonic performances of protesters. We also discuss the additional labor that clinic staff and volunteers must provide to shield patients against this volume of sound, as well as the affective and physical consequences of entering this sound world to receive healthcare. Furthermore, we describe the inherent difficulties in regulating sound and the importance of understanding the intent and context of sound-making in identifying certain sounds as violent. We argue for a more rigorous regulation of sound-making outside of clinics, as it perpetuates not only abortion stigma but also gendered sonic violence on all people who enter abortion clinics.
The preposition under and its noun collocates in the under-NOUN pattern: A quantitative corpus-based investigation
Authors:   Siedlce University of Natural Sciences and Humanities, Wiliński Jarosław
Published: February 2021

This paper adopts a usage-based perspective on grammatical structure (Goldberg 2006, 2013) and the attraction-reliance measure (Schmidt 2000; Schmid & Küchenhoff 2013) to gauge the reciprocal interaction between a noun and the preposition under in the under-NOUN pattern: in other words, to determine strongly attracted nouns of this preposition. On the basis of the data extracted from the academic part of the Corpus of Contemporary American English (COCA), this paper seeks to show that there are nouns that are more strongly attracted to the preposition under than others and that the co-occurrences of particular nouns with this preposition are more significant than others. In addition, the results of the analysis seem to suggest that the mutual associations between particular nouns and this preposition depend upon different senses of under and are therefore motivated by conceptual metaphors, metonymies, and/or image schemas.
Hemolysis and Neurologic Impairment in PAMI Syndrome: Novel Characteristics of an Elusive Disease
Authors: Del Borrello Giovanni , Guardo Daniela , Micalizzi Concetta , Ceccherini Isabella , Miano Maurizio , Gattorno Marco , Dufour Carlo
Published: February 2021

PSTPIP1-associated myeloid-related proteinemia inflammatory (PAMI) syndrome is a rare early-onset autoinflammatory disease associated with various hematologic findings, including chronic neutropenia and pancytopenia. We report a unique case of PAMI syndrome in a toddler with transfusion-dependent hemolytic anemia, hepatosplenomegaly, failure to thrive, developmental delay, and multiple malformations. Because of acute inflammatory-driven decompensation, anakinra was started with dramatic improvement of both the hematologic and neurologic involvement. A customized next-generation sequencing panel later identified a de novo pathogenic variant in the PSTPIP1 gene, confirming the diagnosis. Our case illustrates the broad spectrum of phenotypes associated with PAMI syndrome, which should be considered in any case of unexplained cytopenias associated with autoinflammatory stigmata. It is also one of the few reports of neurologic involvement in PSTPIP1-associated inflammatory diseases. Increased awareness of this rare disease and early performance of genetic testing can correctly diagnose PAMI syndrome and prevent disease complications.
Slovakian Hungarian prose in Slovakia after the change of regime in 1989
Authors: Tóth Anikó N.
Published: February 2021

The present study showcases the achievements of Slovakian Hungarian prose in the past three decades. It shows the changes in the literary institutional system brought about by the change of regime in 1989. It devotes detailed attention to the careers of Lajos Grendel and Alfonz Talamon; furthermore, it highlights some characteristic poetics and uses of language which resulted in intriguing works by Gábor Farnbauer, Attila Győry, Daniel Levicky Archleb, Zsófia Bárczi, József Gazdag, Norbert György, and Péter Hunčík. It also touches upon the experiments of the younger generation of prose writers such as Zoltán Szalay and Pál Száz.
Minority language policy and bilingual name semiotic landscape in Slovakia
Authors: Bauko János
Published: February 2021

The present paper addresses the issue of the interrelatedness of Slovakia’s minority language policy and the bilingual name semiotic landscape; more specifically, the name semiotic landscape of settlements populated by Slovakia Hungarians and the way Slovakia’s laws regulating name use affect visual proper noun use in the country. The name semiotic landscape constitutes an integral part of the linguistic landscape, comprising proper nouns and extralinguistic signs referring to, or accompanying names in name plates, signage in public spaces, and on various other surfaces. The name semiotic landscape is a component, an aspect, and a consequence of language policy and name policy. The way minority proper nouns can be displayed in public spaces is regulated by laws approved by the state. Some areas (such as personal name plates, business cards, and names of private institutions) are unregulated, and the forms of proper nouns can be chosen freely. This paper seeks to answer the following questions: to what extent are minority language rights implemented in visual name use in settlements populated by Slovakia Hungarians, whether Hungarian name usage is spreading, and to what extent do signage and name plates contain proper nouns in a Hungarian form. In bilingual societies, proper nouns and other signs in the minority language increase the prestige of the minority language and have the function of marking ethnic identity. In this paper, the proper noun semiotic, place name semiotic, and institution name semiotic landscapes are investigated for various proper noun types in Slovakia Hungarian settlements.
The “we” vs. “they” distinction in Slovakia Hungarians' discourse
Authors: Vančo Ildikó
Published: February 2021

Linguistic differentiation is a basic component of sociocultural differentiation: social processes create the social and linguistic meanings of variants, sometimes also contributing to language change through discourse processes. In addition to being continuously constructed, discourse is in a dialectic relationship with extra-discursive factors and can therefore be studied only when embedded in its social and linguistic contexts (cf. Fairclough 2010: 3–5, Laihonen 2009). In this article I investigate how the notion of “we” occurs in the metalinguistic discourse of Hungarian speakers in Slovakia (with reference to Slovakia Hungarians and their Hungarian language use) (cf. Kontra 2006) in contrast with the notion of “they” (with reference to Hungary Hungarians and their Hungarian language use) in lay speakers' utterances referring to language. The study reported on in this article uses directed interviews and employs discourse analysis to provide insight into the use of “we” vs. “they” and their meanings in the Slovakia Hungarian variety. It also seeks to show how certain expressions become indexical in conceptualizations of identity and how the distinction of “we” vs. “they” is created by language.
Teología y derecho canónico. Reflexiones desde la Teología
Authors: Izquierdo César
Published: February 2021

La teología y el derecho canónico tienen mucho en común, y entre ellas no es infrecuente algún grado de incomprensión mutua. Los teólogos recelan de una excesiva juridización de la realidad cristiana por parte de los canonistas. Estos a su vez desconfían de una “pastoralidad” en la interpretación de las normas por parte de los teólogos que acabe afectando a la justicia y a los derechos de los fieles. El autor examina la cuestión desde el punto de vista teológico y considera críticamente cuatro aspectos que afectan tanto a la teología como al derecho canónico: el objeto, la sistematicidad, la normatividad y el principio de autonomía. Plantea finalmente un posible punto de encuentro de la teología y del derecho canónico en el modo de entender la salus animarum.
El control judicial del principio de proporcionalidad en los actos administrativos
Authors: Rodríguez-Ocaña Rafael
Published: February 2021

SUMARIO: 1. Intervención papal. 2. La competencia para conocer de los delitos contra el sexto mandamiento del decálogo y de los recursos contra las decisiones disciplinares previas al inicio del proceso judicial o administrativo penal. 3. El principio de proporcionalidad. 4. El control judicial de la proporcionalidad.
HIGHER EDUCATION LEADERSHIP PRACTICES AND CHALLENGES IN A CHANGING WORLD: THE CASE OF A UNIVERSITY OF TECHNOLOGY
Authors:   Vaal University of Technology, South Africa, Madzimure Jeremiah
Published: February 2021

The aim of the study is to explore the leadership practices and challenges at a university of technology in South Africa. This study adopts a qualitative, interpretive approach. I preferred to use in-depth individual interviews with five participants who were purposively selected from one university of technology (UoT) in South Africa. The interview data was analyzed using thematic analysis (TA) through an inductive process. Four themes emerged from the data analysis. The study recommends that university need to respond effectively to the leadership challenges and as well management in higher education institutions need to acquire skills and leadership practices in line with the 21st century. This study contributes to the literature on higher education leadership in South African UoTs which was noted to be scant.
THE USE OF MARKETING AS A TOOL FOR COMPETITIVE ADVANTAGE AMONG POTENTIAL AND PROFESSIONAL FOOTBALL CLUBS IN KZN, SOUTH AFRICA
Authors:   Durban University of Technology (DUT), South Africa, Abon Joseph Kolawole
Published: February 2021

Football, as the most popular sport amongst other sports, is a household name in the world and South Africa particularly. This study examines the use of marketing in improving competitive advantage among potential and professional football clubs in KwaZulu-Natal, South Africa. Several sponsorship opportunities that could serve as an impetus to disseminate various club projects are noted to be undermined. Arguably, some of the clubs’ activities are seasonal, and the applicability of marketing by football clubs in the KZN province could not be tactically emphasized. Therefore, the amount of marketing activities in clubs’ seasonal operations is unidentified which poses a challenge in achieving club objectives. This paper argues that it is of importance for the club marketing managers to consider features of each specific season and corporate marketing activities for the development of appropriate marketing actions that could serve as competitive advantages. This study adopts a mixed-method research approach, and a convenient sampling technique with responses from 80 questionnaires were retrieved. Five (5) coaches, 5 club owners, 5 managers, 5 supporters, and 5 players from five football clubs each located in KwaZulu-Natal province were interviewed to extract their understanding of the use of marketing to gain competitive advantage. Findings from the study state that using marketing correctly could improve the chances of potential professional football clubs’ popularity and increase financial gains. Most respondents emphasized that when clubs use a proper marketing strategy with appropriate use of marketing mix, it could position the clubs in the hearts of their supporters and public.
EDUCAÇÃO FINANCEIRA COMO ESTRATÉGIA NA FORMAÇÃO INTEGRAL DOS ESTUDANTES DA EDUCAÇÃO PROFISSIONAL E TECNOLÓGICA
Authors: Gonçalves Marina , Neves Rafael Felipe Coelho
Published: February 2021

O presente artigo é uma contribuição para que o ensino de Educação Financeira possa ser difundido e estimulado. Por meio de um produto educacional e com ênfase no consumo consciente do dinheiro e do crédito, esse trabalho objetivou registrar a percepção dos estudantes e do professor sobre a introdução do tema na Educação Profissional e Tecnológica. A coleta de dados se efetivou por meio de aplicação de questionários e ocorreu em três etapas. A aplicação do produto educacional, no formato de cartilha, foi realizada pelo professor, por meio de aula expositiva e com utilização de exemplos práticos do cotidiano. Este trabalho, além de facilitar a compreensão de conceitos, também fornece informações e condições para que estudantes e professor transformem os conhecimentos em comportamentos financeiros saudáveis.
PERCURSOS E TRAJETÓRIAS EM EDUCAÇÃO PROFISSIONAL E TECNOLÓGICA: OS CURSOS DE LICENCIATURA NO IFF CAMPUS CAMPOS CENTRO
Authors: Carvalho Camila Borges Barreto de , Barcelos Gilmara Teixeira
Published: February 2021

A Educação Profissional e Tecnológica, como modalidade de educação voltada para a praxis, ganhou proeminência com o movimento de expansão da Rede Federal e sua abrangência no território nacional. Nesse contexto, à luz das categorias: institucionalidade, trajetória histórica e distintividade busca-se compreender o perfil institucional dos cursos de licenciatura do campus cCampos Centro do Instituto Federal Fluminense. A pesquisa teve uma abordagem qualitativa com utilização de entrevistas semiestruturadas com gestores institucionais e os dados coletados foram analisados a partir da revisão da literatura e também por meio da análise de conteúdo.  O perfil institucional dos cursos investigados é constituído a partir da afinidade eletiva entre uma institucionalidade específica, uma trajetória histórica particular e uma distintividade que conferem um modelo próprio a essas licenciaturas.
Rodzina współczesna - dysonans pomiędzy preferowanym modelem życia a znaczeniem życia rodzinnego
Authors: Juszczyk-Frelkiewicz Katarzyna
Published: February 2021

In the work the chosen as­pect of sociological empirical research, carried out among the students of the Constantine the Philosopher University in Nitra and among students of the University of Silesia in Katowice, con­cerned their opinion on family life in the contemporary world and their preferred model of life and plans concerning mar­riage in the future
Rodzina wiktymologiczna reżyserem zagrożonego człowieczeństwa : podejście eudajmonistyczno-felicytologiczne
Authors: Gawęcka Mirosława
Published: February 2021

The article presents issues of victymological’s family, the essence of which is deposited on the destructive patterns of interaction. Shows the coor­dination of multiple perspectives in the­oretical approach in defining, explain­ing and understanding the experience victymological in the family. The arti­cle “Presentations problems of the fam­ily” based on the presentation: – the­oretical approaches to explaining and understanding the experience victymo­logical in the family, – presentations ex­periencing victimization of family own­ership, – principion family functioning and principles of functioning in the vic­tymological family. Due to the disclo­sure in this type of family disruption and problems in the functioning moral, constitute a direct threat to the develop­ment of humanity by each of its mem­bers in the article attempts to outline the framework concept of social work in terms of eudaimonisty ­felicytology’s understood as the repair and improve­ment of the moral laws by appointment in each of themselves and sense of self­­determination for inner transformation through raising awareness on the v alue, access to the truth, directing their own good, or inner spiritual transformation that allows the reconstruction of welfare and rooted in the moral improvement of humanity.
Sociálno-patologické javy v rodine s dieťaťom so špeciálnymi výchovno-vzdelávacÍmi potrebami
Authors: Šip Maroš
Published: February 2021

The issues related to socio­­pathological phenomena, are perceived as having serious social and other psy­chological consequences. Violence of any type is defined as a premeditated act, ag­gression as a way of disrupting human dignity, as seriously endangering the quality of human life, the freedom of the human being. The aim of our contribu­tion is to define socio ­pathological phe­nomena relating to children with special educative needs.
Opieka naprzemienna : ocena projektu ustawy (Druk Sejmu VII kadencji nr 3104)
Authors: Kroczek Piotr
Published: February 2021

In its ruling on the divorce, the court rules on joint parental author­ity over a minor child of both spouses. Under the current legal regime, it has become a common practice, that the court delegates the exercise of paren­tal authority to one of the parents, lim­iting the parental authority of the sec­ond parent to specific rights and duties in relation to the child. The proposed amendment to the Act of 25th February 1964 – the Family and Guardianship Code (form 3104) was drafted by the Codification Committee of Family Law that cooperates with the Commissioner for Children’s Rights. The new law intro­duces, co called, an “alternate custody”. The solution is to limit the transgression of the child’s right to be brought up by both parents. The aim of the paper is to evaluate the bill in question.
Religijność a osobnicza perspektywa względem rodziny i względem doświadczeń w rodzinie - ujęcie psychologiczne
Authors: Borowska Monika Maria
Published: February 2021

It has been assumed that re­ligiousness is one of the factors that are instrumental (though not normative) in shaping the life of an individual in a con­scious way. In an attempt to determine what role family plays in human life, the above ­mentioned factor was perceived as vital in shaping the senses and mean­ing assigned to the family by an individ­ual. The studies (presented in the con­text of life ­span developmental psychol­ogy) have an exploratory character and constitute an attempt to demonstrate and establish the type of relationship that exists between the cognitive per­spective of an individual on the selected aspects of family life and the level and style of their religiousness. The meth­ods applied: Questionnaire on the place of family in the course of life – MRŻ (Katedra Psychologii UPJPII – the Chair of Psychology, Pontifical University of John Paul II in Kraków 2015 – exper­imental version) author’s own design and Questionnaire on religiousness (by C. Walesa et al., KUL, 2014). The talk is going to include a presentation and a de­tailed study of selected cases chosen out of several dozens of completed question­naires (the respondents included people from three age groups: early, middle and late adulthood).
Ako čeliť vplyvom digitálneho sveta na Cirkev a rodinu 21. storočia
Authors: Vojtko Stanislav
Published: February 2021

The lecture deals with the di­agnoses of the contemporary family af­flicted by information and communica­tion technologies. It analyzes both their positive aspect: prompt information, fast communication; but also the negative aspect: e.g. the spreading of religious liberalism, materialistic consumerism, pansexualizmus, penetration of gender ideology. According to the author it is possible to counter the negative effects of the digital world on church and fam­ily communities returning to the cardi­nal virtues as well as to the way of life presented by the Acts of the Apostles (Acts 2: 41–44; 4:32) in the description of the initial Christian community (five pillars of the authentic Christian com­munity: the word of God, teaching of the apostles, prayer, breaking of bread, fel lowsh ip).
Wsparcie dziecka w sytuacji rozwodu rodziców
Authors: Lewicka-Zelent Agnieszka , Huczuk Sylwia
Published: February 2021

The parents’ divorce consti­tutes a threat to the mental, emotion­al and social development of the child. Research done hitherto points to direct and deferred negative consequences of divorce for all family members, espe­cially the youngest ones, susceptible to the influence of others – the children. This difficult crisis situation is reflect­ed in the behaviour of the adults who are experiencing it. Adult children of divorcing parents frequently live with the stigma of a child who is rejected and unloved. As a result, they function ab­normally in families of their own. It is therefore important to provide special support for the children whose parents have decided to divorce. Family me­diation is a good opportunity to set­tle the material and social situation of these families. Mediation meetings can help parents realize the mistakes they make which arise from very high lev­els of negative emotions resulting from the break ­up. This article aims to show the effects of the parents’ divorce on the children and to show specific ways to as­sist them in overcoming this crisis sit­uation. One of the suggestions of sup­port is the use of therapeutic fairy tales to explain to children the new family situation in which they find themselves. Proceeding from this assumption, the authors of the article decided to gather the opinions of parents and their chil­dren about fairy tales about divorce. For this purpose we have employed a ques­tionnaire of our own as well as fairy tales written for children of divorcing parents.
Análisis de componentes principales utilizando python para identificar clúster asociados a muestras de cacao seco sano e infectado con monilia en Norte de Santander
Authors: Flórez-Martínez Alexander , Vargas-Flórez Jesus Omar , Perez-Waltero Harold Esneider , Quintana-Fuentes Lucas Fernando
Published: February 2021

El resultado del proyecto de investigación está asociado a data proveniente de la implementación de un sistema electrónicomultisensorial o común mente denominado olfato electrónico. Mediante el uso de un sistema de adquisición de datos y software LabView sealmacena la data de la concentración de volátiles asociados a muestras de cacao sano e infectado con monilia, aplicado en la fase o etapa desecado. Una vez adquirido los datos se procede a implementar en el software Python el pre-procesamiento y procesamiento de data, permitiendoal usuario por medio de un gráfico identificar el clúster asociados a cada clase, cacao sano o con monilia. Como método para aprendizaje deautomático no supervisado, se implementa análisis de componentes principales PCA para el respectivo procesamiento. Los resultados obtenidosvarían de acuerdo al método de preprocesado de datos. Para el desarrollo se implementó un escalador robusto y preprocesado euclidiano, el cualpresenta mejores resultados de agrupamiento de muestras por clase
Determinación de la viabilidad de semillas de capsicum annuum L usando la prueba de tetrazolio
Authors: Salazar-Mercado Seir Antonio , Quintero-Caleño Jesús David , Rojas-Suárez Jhan Piero
Published: February 2021

El pimentón (Capsicum annuum L) es uno de los cultivos de hortalizas más importantes y ampliamente cultivados a nivel mundial. Este estudio determinó la eficacia del test tetrazolio para obtener la viabilidad de semillas de C. annuum. De manera que, semillas de C. annuum se expusieron a dos concentraciones (1% y 0.5%) de tetrazolio y dos tiempos de exposición (24 y 48horas). La prueba de tetrazolio se fundamenta en la coloración del embrión y tejidos vivos de la semilla, gracias a la oxidación de la sal de tetrazolio por la respiración celular.Ulteriormente, utilizando un microscopio estereoscopio se valoró la tinción de las semillas, estimando como semillas viables las que presentaron coloración roja en el embrión. Por consiguiente, se obtuvieron diferencias estadísticamente significativas (P≤ 0,05) en el tratamiento T4 (0.5 %, 48h) con un 99% de viabilidad. Así mismo, los tratamientos T1 (1 %, 24h) y T2 (0.5 %, 24h) no presentaron diferencias entre sí, siendo el porcentaje de viabilidad 89% y 91% respectivamente. Para la prueba de germinación real, se obtuvo un 84.4% (promedio) de germinación para las 5  repeticiones. Se concluye que mediante el ensayo de tetrazolio la valoración de la viabilidad en semillas de pimentón es eficiente para las concentraciones de 1% y 0.5 %, durante 24 horas
Objetos de aprendizaje y desarrollo de habilidades del pensamiento numérico: Análisis mediante un diseño cuasiexperimental.
Authors: Albarracín-Villamizar Carmen Zulay , Hernández-Suárez César Augusto , Prada-Núñez Raúl
Published: February 2021

Este trabajo buscó valorar el desarrollo de las habilidades numéricas de los estudiantes de básica primaria mediado por un objeto aprendizaje como apoyo al proceso de aprendizaje del pensamiento numérico. Se presenta un análisis con el método cuasiexperimental mediante la aplicación de un pretest - postest, validado por juicio de expertos. Se uso un objeto virtual sobre los números, el cual se centró en favorecer el aprendizaje de los estudiantes y comprensión de los conceptos. Esto permitió analizar el progreso académico de los estudiantes. Se demostró la incidencia en el desarrollo de las habilidades numéricas en el grupo de estudio, pero, no es concluyente ni posibilita realizar generalizaciones sobre el efecto del objeto de aprendizaje en el aprendizaje de los números.
PBX IP como herramienta de integración de servicios de comunicaciones para la UFPS basado en las mejores prácticas de ITIL.
Authors: Pardo-García Carlos Eduardo , Diaz-Leal Nelly Rosana , Gómez-Llanez Claudia Yamile
Published: February 2021

La telefonía de voz sobre el protocolo de Internet IP (VoIP) contempla beneficios en la implementación, permitiendo la comunicación entre usuarios de la empresa, sucursales y demás interesados representando un ahorro; siendo esta tecnología tendencia en comunicación telefónica empresarial y posibilitando la transmisión de voz humana a través de redes de transmisión de datos.Profundizando en esta tecnología y en sus beneficios, se diseña una central telefónica para el Departamento de Sistemas e Informática como modelo piloto en la Universidad Francisco de Paula Santander, ofreciendo servicios VoIP. Este modelo es factible de extender a la sede Cúcuta y demás sedes y dependencias dispersas geográficamente como; Los Patios, los CREAD (Centros Regionales de Educación Abierta y a Distancia) y la Seccional Ocaña.En esta implementación de la Central Privada Automática PBX (Private Branch Exchange), se considera aplicar las buenas prácticas para la gestión de servicios informáticos ITIL (Information Technology Infrastructure Library) que permita lograr la calidad y eficiencia en las operaciones asociadas a la solución de comunicaciones propuesta.La ventaja de este tipo de tecnología es el ahorro para la organización que la implemente; debido a que la VoIP, se transmite a través de las redes de datos de la organización y es posible enrutar a través de la red Internet servicios estratégicos que se Integren con sistemas de atención a cliente y centros de llamadas de call center, vía soluciones abiertas o propietarias de la institución. Además, el servicio se optimiza con alojamiento en la nube, centralizando la administración, el mantenimiento y la gestión lo cual redundará en los beneficios económicos de bajos costos y fácil escalabilidad.El proyecto desde la perspectiva institucional es importante, puesto que es un sistema de comunicaciones el cual busca mejorar el servicio al cliente y a las personas que intervienen en los procesos organizacionales; dejando de utilizar medios de comunicación personal en actividades laborales.