bluuebunny/crossref_metadata_2025 huggingface dataset:
Penderitaan Dalam Karya Seni Instalasi
Authors: Arvinda Shavierra , Moerdisuroso Indro
Published: March 2024

Agony (penderitaan) adalah sesuatu yang tidak dapat dihindari dalam kehidupan seseorang karena hidup tidak selalu tentang kebahagiaan. Setiap manusia pasti pernah merasakan sakit hati, kehilangan, kekecewaan ataupun segala rasa yang seakan dapat meruntuhkan kehidupan. Penderitaan dibangkitkan oleh memori yang pernah ada dan melibatkan emosi. Setiap individu pasti akan merasakan penderitaan, setidaknya sekali seumur hidup. Penderitaan adalah sebuah proses yang harus dilampaui sebagai manusia untuk mengenali rasa sakit, bertahan dalam hidup, dan menjadi manusia yang lebih baik. Konsep Post Traumatic Growth menjelaskan bahwa setiap manusia dapat mengubah rasa sakit dan penderitaan menjadi energi baru untuk tumbuh menjadi manusia yang lebih kuat. Penciptaan karya ini mengambil paham teori The Birth of Tragedy yang menjelaskan bahwa manusia memiliki kekuatan nalar, irasionalitas, struktur, kekacauan, individualisme, dan kesatuan kosmik di dalam diri. Manusia membutuhkan keduanya. Jika manusia kehilangan salah satu, membuat kehilangan kemampuan kita sendiri untuk menjadi orang yang lengkap dalam menjalani kehidupan. Penciptaan karya menggunakan Interes bentuk figuratif, interes seni, reflektif, dan interes estetik kontemporer. Karya dibuat sebagai simbol refleksi diri. Perenungan terhadap kegiatan yang telah dilakukan dengan menciptakan pemikiran baru yang bertujuan meningkatkan kualitas diri seseorang untuk menjadi manusia yang lebih baik. Karya berupa Seni Instalasi yang mewakili makna dan relevansi konsep pada setiap elemen yang ditampilkan. Karya akan merepresentasikan ekspresi dan ungkapan perasaan menderita dari seniman dan orang sekitar dalam menjalani kehidupan yang juga merasakan kondisi hancur, kesedihan, kesepian, ketidakstabilan maupun kehilangan.
Long-Term Outcomes of Birmingham Hip Resurfacing Arthroplasty
Authors: Molloy J. , Handford C. , Coolican J. , Molloy T. , Walter W.
Published: March 2024

Background:

Hip resurfacing arthroplasty (HRA) provides an attractive alternative to total hip arthroplasty (THA) for the management of osteoarthritis in younger, more active patients; however, concerns persist over complications specific to HRA. The aims of this systematic review were to assess the documented long-term survival rates of the metal-on-metal BIRMINGHAM HIP Resurfacing System at a follow-up of at least 10 years and to analyze the functional outcomes and cause of failures.

Methods:

A systematic review was undertaken of all published cohort studies available in the MEDLINE, Cochrane, Embase, and PubMed research databases up to December 2021, as recommended by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data extraction was focused on survival rates, causes of failure, and functional outcomes. Survival estimates at 10 years were pooled in a meta-analysis, with each series weighted by its variance. Causes of failure were presented as a percentage of the pooled revisions.

Results:

A total of 11 studies were identified, encompassing 3,129 cases. Across the 9 studies that had reported a mean follow-up, the mean follow-up was 11.7 years (range, 9.55 to 13.7 years). We found a pooled 10-year survival rate of 95.5% (95% confidence interval, 93.4% to 97.1%). There were 149 revisions among the studies (range, 4 to 38 revisions per study), a rate of 4.8% of the total procedures performed. The 2 main causes of revision were aseptic loosening (20.1% of revisions) and adverse reactions to metal debris (20.1%). There were no revisions for dislocation. Of the studies that reported preoperative functional scores, all reported significant improvement in mean scores postoperatively except for 1 study in which the mean Tegner activity score did not significantly improve.

Conclusions:

When performed for appropriate indications, patients undergoing an HRA with use of the BIRMINGHAM HIP Resurfacing System can expect good implant survivorship at 10 years with acceptable functional results and low rates of dislocation and infection. This systematic review, however, confirms concerns regarding adverse reactions to metal debris as a leading cause of revision.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Enhancing Fundraising with Digital Transaction in Indonesia: A Systematic Literature Review (SLR)
Authors: Safitri Devi Herlinda , Dzikrulloh Dzikrulloh
Published: March 2024

This research uses the Systematic Literature Review (SLR) method to investigate the optimization of collecting Zakat, Infaq and Sadaqah funds through digital transactions. The data analysis process uses the PRISMA diagram and includes the stages of identification, search, selection, data collection and analysis. From three main sources, researchers collected 20 references, consisting of theses and journals, which were analyzed to identify findings related to collecting ZIS funds with digital transactions in Indonesia. The results reflect the digitalization trend, where zakat institutions are increasingly using information technology to increase efficiency, accessibility and transparency in the process of collecting ZIS funds. This trend involves utilizing mobile applications, QRIS, and digital platforms, enabling faster and more efficient fund collection. Other benefits include ease of access, increased transparency, and more effective involvement of muzakki. Using digital technology also enables data analysis, better fund management and the development of sustainable business models. The COVID-19 pandemic has triggered new strategies in collecting ZIS funds, with zakat institutions turning to social media and digital platforms as alternatives to raise funds. Online payment services with mobile QR Codes are key in maintaining the continuity of ZIS fund collection amidst physical restrictions. Socialization efforts, easy access, and partnerships with various parties are the main strategies for zakat institutions to remain relevant and effective in facing the challenges of the pandemic. This research focuses on the central role of digitalization in increasing the efficiency and effectiveness of collecting ZIS funds, such as paying attention to social changes, namely the COVID-19 pandemic. By using digital technology, zakat institutions can continue to innovate and meet the needs of muzakki, so that they continue to play their role in helping people in need.
Data-Driven Dynamic Inversion Method for Complex Fractures in Unconventional Reservoirs
Authors: Jia Ruixue , Li Xiaoming , Ma Xiaoyong , Zhu Liang , Guo Yangdong , Song Xiaoping , Wang Pingde , Wang Jiantao
Published: March 2024

Hydraulic fracturing is a crucial technology for enhancing the recovery of oil and gas from unconventional reservoirs. Accurately describing fracture morphology is essential for accurately predicting production dynamics. This article proposes a new fracture inversion model based on dynamic data-driven methods, which is different from the conventional linear elastic fracture mechanics model. This method eliminates the need to consider complex mechanical mechanisms, resulting in faster simulation speeds. In the model, the fracture morphology is constrained by combining microseismic data and fracturing construction data, and the fracture tip propagation domain is introduced to characterize the multi-directionality of fracture propagation. The simulated fracture exhibits a multi-branch fracture network morphology, aligning more closely with geological understanding. In addition, the influence of microseismic signal intensity on the direction of fracture propagation is considered in this study. The general stochastic approximation (GSA) algorithm is employed to optimize the direction of fracture propagation. The proposed method is applied to both the single-stage fracturing model and the whole well fracturing model. The research findings indicate that in the single-stage fracturing model, the inverted fracture morphology aligns closely with the microseismic data, with a fitting rate of the fracturing construction curve exceeding 95%, and a microseismic data fitting rate exceeding 93%. In the whole well fracturing model, a total of 18 sections were inverted. The fitting rate between the overall fracture morphology and the microseismic data reached 90%. The simulation only took 5 minutes, demonstrating high computational efficiency and meeting the needs of large-scale engineering fracture simulation. This method can effectively support geological modeling and production dynamic prediction.
RDW: A New Predictive Indicator in Pancreatic Cystic Neoplasms.
Authors: Martlı Hüseyin Fahri , Acehan Muhammed Fatih , Er Sadettin , Şimşek Ahmet , Şahingöz Eda , Sürel Aziz Ahmet
Published: March 2024

Background
The incidence of pancreatic cystic neoplasms (PCN) is increasing over time. However, identifying between benign and malignant cysts remains difficult. The final diagnosis is always made by postoperative pathology, even with recommendations for cytology and endosonography.This study aimed to investigate the malignancy probability of PCNs using simple clinical and biochemical parameters.
Method
A retrospective analysis was conducted on 70 patients who underwent surgery for pancreatic cystic neoplasms. Based on postoperative pathology, patients were divided into two groups: Group A, which included those with benign or low-grade dysplasia and Group B which included those with dysplasia malignancy or high-grade dysplasia. A comparison was made between pathology results and clinical and laboratory data.
Results
Out of the 70 patients, 42 (60%) were in Group A,and 28 (40%) were in Group B. Univariate analysis revealed that age, diabetes mellitus, red cell distribution width (RDW), and albumin were examined as potential predictors of malignancy in pancreatic cystic neoplasms. In the multivariate analysis, age and RDW were established as independent variables. The AUC values of age, RDW, and the combination of age and RDW for malignancy or high-grade dysplasia were 0.798 (95% CI: 0.695-0.900), 0.801 (95% CI: 0.692-0.911), and 0.858 (95% CI: 0.771-0.944), respectively.
Conclusion
The differentiation between benign and malignant PCN can only be achieved through advanced and specialized investigations. Postoperative pathology is still the most precise means of diagnosis. Age and RDW can be used as additional criteria to select patients for endosonography and cytological evaluation, and to precisely identify patients who might need surgical intervention.
Covariate-constrained randomization in cluster randomized 2x2 factorial trials: Application to a diabetes prevention study
Authors: Siddique Juned , Li Zhehui , O’Brien Matthew J.
Published: March 2024

Background: Cluster randomized trials (CRTs) are randomized trials where randomization takes place at an administrative level (e.g., hospitals, clinics, or schools) rather than at the individual level. When the number of available clusters is small, researchers may not be able to rely on simple randomization to achieve balance on cluster-level covariates across treatment conditions. If these cluster-level covariates are predictive of the outcome, covariate imbalance may distort treatment effects, threaten internal validity, lead to a loss of power, and increase the variability of treatment effects. Covariate-constrained randomization (CR) is a randomization strategy designed to reduce the risk of imbalance in cluster-level covariates when performing a CRT. Existing methods for CR have been developed and evaluated for two- and multi-arm CRTs but not for factorial CRTs.
Methods: Motivated by the BEGIN study—a CRT for weight loss among patients with pre-diabetes—we develop methods for performing CR in 2x2 factorial cluster randomized trials. We apply our methods to the BEGIN study and use simulation to assess the performance of CR versus simple randomization for estimating treatment effects by varying the number of clusters, the degree to which clusters are associated with the outcome, the distribution of cluster level covariates, and analysis strategies.
Results: Compared to simple randomization of clusters, CR in the factorial setting is effective at achieving balance across cluster-level covariates between treatment conditions and provides more precise inferences. When cluster-level covariates are included in the analyses model, CR also results in greater power to detect treatment effects, but power is low compared to unadjusted analyses when the number of clusters is small.
Conclusions: CR should be used instead of simple randomization when performing factorial CRTs to avoid highly imbalanced designs and to obtain more precise inferences. Except when there are a small number of clusters, cluster-level covariates should be included in the analysis model to increase power and maintain coverage and Type 1 error rates at their nominal levels.
Waste Picking in the Age of COVID-19: An Environmental Justice Perspective
Authors: Shanmugasundaram Lalitha
Published: March 2024

All over the world, waste and the disposal of waste is becoming a more prominent issue, as landfills fill up and more evidence points to landfills and trash contributing to climate change and environmental degradation. In the developing world, waste pickers sort through solid waste and sell it to vendors, who will recycle the product into something consumable. The work they do is vital to climate change mitigation, as well as urban cleanliness. In a way, waste pickers, especially in India, are vehicles of environmental justice, but they are often discriminated against, subjected to inhumane working conditions, and can barely make a living. During this all, the pandemic hit, making waste pickers’ already precarious life even worse. This paper attempts to fill the gap in the academic literature by compiling a systemized literature review of the impacts of COVID-19 on waste-pickers’ lives using an environmental justice perspective. The review also uses a Feminist Political Ecology perspective to illuminate the double jeopardy that female waste pickers face in the era of COVID-19, which is often ignored in academia. Ultimately, this paper shows that COVID-19 exacerbated preexisting injustices that the waste picker community faced and created an immense burden on women. This paper will show that it is important to notice the differentiation between female and male waste picker challenges, especially at the crux of the COVID-19 pandemic. This paper has important policy implications as well as research considerations for both environmental justice and feminist political ecology scholars.
Studying the factors that affect urban road noise – Case study: El-Tahrir Street, Al-Dokki Cairo, Egypt
Authors: Alyeldin¹ R. A. , Seddiq H. , Nour Walaa , El-boshy Bahaa
Published: March 2024

Expanding road networks to accommodate various activities has increased urban noise pollution, adversely affecting human health and quality of life. Numerous factors, including road characteristics, traffic characteristics, surrounding buildings, and weather conditions. This study aims to monitor and analyse the effect of these factors on the noise level. Cairo is one of the most densely populated cities in the world, which has led to a high level of noise in its different areas. One of the most crowded areas in the city is El-Tahrir Street in Al-Dokki, which was selected as a case study in this research. This area is distinct by a wide range of services and activities, and it experiences high traffic volume, with up to 1,700 vehicles passing through within a 15-minute interval. This significant traffic volume is the primary driver of the elevated noise levels in the area. Traffic and noise level monitoring has been conducted using reliable equipment to study this issue. Consequently, a statistical analysis has been conducted to investigate the correlation between different factors and the noise level to determine the most influential factors that could help draw future intervention plans.
Risk factors for food insecurity and association with prenatal care utilization among women who took opioids during pregnancy
Authors: Parlberg Lindsay M. , Newman Jamie E. , Merhar Stephanie , Poindexter Brenda , DeMauro Sara , Lorch Scott , Peralta-Carcelen Myriam , Wilson-Costello Deanne , Ambalavanan Namasivayam , Limperopoulos Catherine , Mack Nicole , Davis Jonathan M. , Walsh Michele , Bann Carla M.
Published: March 2024

Background. Food insecurity during pregnancy is associated with poorer outcomes for both mothers and their newborns. Given the ongoing opioid crisis in the United States, mothers who take opioids during pregnancy may be at particular risk of experiencing food insecurity.
Methods. This research utilized data from 254 biological mothers of infants in the Advancing Clinical Trials in Neonatal Opioid Withdrawal Syndrome (ACT NOW) Outcomes of Babies with Opioid Exposure (OBOE) Study. We examined factors associated with food insecurity among mothers of infants with antenatal opioid exposure and their unexposed (control) counterparts. Chi-square tests and logistic regression were used to compare food insecurity by sociodemographic characteristics, opioid use, prior traumatic experiences, and housing instability. Similar analyses were conducted to examine the relationship between food insecurity during pregnancy and receipt of adequate prenatal care.
Results. Overall, 58 (23%) of the mothers screened positive for food insecurity. Food insecurity was more common among mothers who took opioids during pregnancy (28% vs. 14%; p =0.007), had public insurance (25% vs. 8%; p = 0.027), had housing instability (28% vs. 11%, p = 0.002), experienced three or more adverse experiences in their childhood (37% vs. 17%; p < 0.001), and reported physical or emotional abuse during their pregnancy (44% vs. 17%; p < 0.001). Mothers with food insecurity during pregnancy were less likely to have received adequate prenatal care (78% vs. 90%; p = 0.020). This difference remained after controlling for demographic characteristics (AOR (95% CI) = 0.39 (0.16, 1.00), p = 0.049).
Conclusions. This study adds to the body of evidence supporting the need for screening and development of interventions to address food insecurity during pregnancy, particularly among mothers of infants with antenatal opioid exposure, for which limited data are available. The findings revealed that food insecurity frequently co-occurs with housing instability and prior trauma, indicating that a multifaceted intervention incorporating principles of trauma-informed health care is needed. Although those with food insecurity are at increased risk for poor pregnancy outcomes, they were less likely to have received adequate prenatal care despite high levels of public insurance coverage among study participants, suggesting additional strategies are needed to address barriers to health care among this population.
Trial registration. The Outcomes of Babies with Opioid Exposure (OBOE) Study is registered at Clinical Trials.gov (NCT04149509) (04/11/2019).
Acute Promyelocytic Leukemia in Children Cancer Hospital Egypt
Authors: Semary Samah Fathy , Hammad Mahmoud , Yassin Dina , Elsharkawy Nahla , Soliman Sonya , Salem Sherine , Ezzat Emad , Mosa Ahmed , Ahmed Sonia
Published: March 2024

Background: Paediatric acute promyelocytic leukemia (APL) accounts for 5% to 15% of all myelocytic leukemia. A retrospective study of pediatric patients diagnosed and treated with APL was done from July 2012 till the end of December 2019 at CCHE, aimed to, report the prevalence, clinical features, outcomes, and risk factors causing induction failure and early deaths.
Result: Sixty-two patients were reported, age above 10, initial unsatisfactory coagulation profile, and total leukocyte count above 30 103/mm affecting the 5 years (5y) overall (OS) and event-free survival (EFS), high promyelocyte count affecting the 5y EFS. Patients received protocol adopted from COG AAML1331 protocol. Prognostic factors causing early deaths during induction are high-risk patients with initial TLC >10x103/mm and initial promyelocytic count above 30% with significant P-value. In the female gender, wild FLT3 increases the occurrence of differentiation syndrome (DS). Receiving steroids with all-trans retinoic acid (ATRA) in induction may minimize the frequency of DS. Relapse affecting the outcome, Bone marrow transplantation was done for 4 patients of the relapsed patients, with 5y OS 37%, with no significance. In the current study, forty-five patients are alive in complete remission with 5y OS of 72.5%, with 5y EFS of 69.4%, respectively.
Conclusion: pediatric APL outcome is affected by age above 10, initial unsatisfactory coagulation profile and promyelocyte count above 10%. Early death is affected by an initial leukocyte count above 10 x103/mm and, an initial promyelocytic count above 30%. Receiving steroids with ATRA may minimize the frequency of DS.
Cryo-Near-Field Photovoltage Microscopy of Heavy-Fermion Twisted Symmetric Trilayer Graphene
Authors: Koppens Frank , Batlle-Porro Sergi , Stepanov Petr , Calugaru Dumitru , Hu Haoyu , Kumar Roshan Krishna , Hesp Niels , Bernevig B. Andrei , Watanabe Kenji , Taniguchi Takashi
Published: March 2024

Ever since the initial experimental observation of correlated insulators and superconductivity in the flat Dirac bands of magic angle twisted bilayer graphene, a search for the microscopic description that explains its strong electronic interactions has begun. While the seemingly disagreeing electronic transport and scanning tunneling microscopy experiments suggest a dichotomy between local and extended electronic orbitals, definitive experimental evidence merging the two patterns together has been much sought after. Here, we report on the local photothermoelectric measurements in the flat electronic bands of twisted symmetric trilayer graphene (TSTG). We use a cryogenic scanning near-field optical microscope with an oscillating atomic force microscopy (AFM) tip irradiated by the infrared photons to create a nanoscopic hot spot in the planar samples, which generates a photocurrent that we probe globally. We observe a breakdown of the non-interacting Mott formalism at low temperatures (∼10K), signaling the importance of the electronic interactions. Our measurements reveal an overall negative offset of the Seebeck coefficient and significant peaks of the local photovoltage values at all positive integer fillings of the TSTG's moiré superlattice, further indicating a substantial deviation from the classical two-band semiconductor Seebeck response. We explain these observations using the interacting topological heavy-fermion model. In addition, our data reveal a spatial variation of the relative interaction strength dependent on the measured local twist angle (1.2° - 1.6°). Our findings provide experimental evidence of heavy fermion behaviour in the topological flat bands of moiré graphene and epitomize an avenue to apply local thermoelectric measurements to other strongly correlated materials in the disorder-free limit.
Temporal Trends of Polychlorinated Biphenyls (PCBs) in Ohio River Channel Catfish from 1989 to 2021
Authors: Cleves Daniel R. , Borrowdale Bridget E. , Argo D. Ryan , Hudson Ryan R. , Tewes Robert A.
Published: March 2024

Polychlorinated biphenyls (PCBs) are a group of long lasting synthetic compounds used in a variety of industrial and electrical applications. These compounds were discharged into the environment as a result of their production and use. They were eventually found to be toxic and ultimately banned. Prior to their ban, enough PCBs had been released into the environment to bioaccumulate in organismal tissues. The Ohio River is one of the most industrialized rivers in the world and its basin is home to over 30 million people making it relevant for the study of PCB contamination. Using a long term data set of fish tissue contaminants collected by the Ohio River Valley Water Sanitation Commission (ORSANCO), temporal trends in total PCBs (tPCBs) were assessed from 1989 to 2021 in Channel Catfish (Ictalurus punctatus), a common species targeted for consumption. These data were originally collected to support state-issued Fish Consumption Advisories (FCAs) that inform the general public regarding safe levels of fish consumption. Due to the nature of how these data were collected, inherent biases in the dataset such as body size, lipid content, location, and contaminant analytical method were identified and addressed to observe trends. Over the study period, tPCBs in Channel Catfish tissue decreased and the rate of decline decreased over time. Additionally, the proportion of FCAs that advised against fish consumption for PCBs drastically declined over time. Few peer reviewed long term trend analyses exist concerning bioaccumulation of industrial pollutants for the Ohio River. This study could serve as a framework of how to account for dataset biases when analyzing monitoring data to observe long term trends in fish tissue contaminants.
Prevalence of antibodies against adeno-associated viruses (AAVs) in Göttingen Minipigs: Implications for Gene Therapy and Xenotransplantation
Authors: Jacobsen Kirsten Rosenmay , Mota Javier , Salerno Michelle , Willis Alexis , Pitts Dennis , Denner Joachim
Published: March 2024

Adenovirus associated viruses (AAV) are well established in clinical trials for in vivo gene therapy. The AAV vector has unique features that are beneficial in clinical applications including broad tropism, low immunogenicity, ease of production, it is non-pathogenic, rarely integrates into the host chromosome and results in long-term expression of the transgene. Göttingen Minipigs are a well-established animal model for several diseases and can be used for efficacy and safety testing of AAV based gene therapy. Antibodies against AAV may influence the results and therefore the animals should be tested beforehand for the presence of antibodies against AAV. The detection of AAV in pig breeds is also important for the virus safety of xenotransplantation. Although the contribution of AAVs to diseases in humans is still under discussion, it cannot be excluded that transfer of AAVs from the donor may result in disease. When we screened Göttingen Minipigs from Ellegaard Göttingen Minipigs A/S, Denmark, and Marshall BioResources, USA, for AAV1, AAV2, AAV6, AAV9, only low titers of neutralizing antibodies (NAb) were detected despite higher titers of total antibodies (TAb). This data indicates that Göttingen Minipigs are well suited for gene therapy studies as well as for xenotransplantation.
A Network Intrusion Detection Model Based on Dilated convolution network and BiLSTM
Authors: Li Yimeng , Gao Yuzhuo
Published: March 2024

Aiming at the intrusion detection model, there are problems such as single dimension of local feature extraction, prediction accuracy to be improved and high computational overhead of the model, an intrusion detection model based on Dilated Convolution Network (DCN) and Bidirectional Long Short Memory Network (BiLSTM) intrusion detection model. Firstly, the improved three-layer Dilated convolution network (DCN) structure is used for local feature extraction, which solves the problem of a single extraction dimension; secondly, the combination of Dilated convolution and BiLSTM is used to solve the problem of the prediction accuracy needs to be improved; and finally, the model is lightened by the introduction of grouped convolution technique in the model. and the feature selection algorithm for feature dimensionality reduction operation to reduce the computational overhead. In this paper, experiments are conducted on the public dataset CICIDS2017, and after comparing the traditional model and existing intrusion detection methods, the analysis shows that the proposed model has better performance. The model prediction accuracy, recall, and F1 value are high, proving its effectiveness and feasibility.
Soy protein selectively accumulates formaldehyde
Authors: Yamada Masanori , Uchida Momoka , Yamada Tetsuya
Published: March 2024

Soy protein (SP) was obtained from degreased soybeans which are discarded as an industrial waste around the world. Therefore, the materials consisting of soy protein are not only environmentally benign but also sustainable materials. We prepared the SP − GPTMS composite materials by mixing the SP and a silane coupling reagent, 3-glycidoxypropyltrimethoxysilane (GPTMS), and demonstrated the accumulation of various aldehydes, such as formaldehyde (HAld), acetaldehyde (AcAld), butyl aldehyde (BuAld), and benzaldehyde (BnAld), by the SP − GPTMS composite materials. As a result, when the composite materials were incubated in an aqueous multi-component solution containing four aldehydes, these materials effectively accumulated the aldehydes. The accumulated amounts of the aldehydes were BnAld < BuAld < AcAld < HAld and the amount of HAld was three times higher than that of BnAld, which had the lowest accumulated amount. These results suggested that the SP − GPTMS composite materials indicated a molecular selectivity for HAld. In addition, the accumulated amounts of HAld further increased under acidic conditions. Furthermore, according to the IR measurements, the HAld-accumulated SP − GPTMS composite materials showed the formation of hydroxymethyl groups. Therefore, the molecular selectivity of HAld in the SP − GPTMS composite material was due to the high electrophilicity of HAld and the low steric hindrance.
Ultra-inert lanthanide chelates as mass tags for multiplexed bioanalysis
Authors: Polasek Miloslav , David Tomáš , Šedinová Miroslava , Myšková Aneta , Kuneš Jaroslav , Maletinska Lenka , Pohl Radek , Dračínský Martin , Mertlíková-Kaiserová Helena , Čížek Karel , Klepetářová Blanka , Litecká Miroslava , Kaňa Antonín , Sýkora David , Jaroš Adam , Straka Michal
Published: March 2024

Coordination compounds of lanthanides are indispensable in biomedical applications as MRI contrast agents and radiotherapeutics. However, since the introduction of the chelator DOTA four decades ago, there has been only limited progress on improving their thermodynamic stability and kinetic inertness, which are essential for safe in-vivo use. Here, we present ClickZip, an innovative synthetic strategy employing a coordination-templated formation of a 1,5-triazole bridge that improves kinetic inertness up to a million-fold relative to DOTA, expanding utility of lanthanide chelates beyond traditional uses. Acting as unique mass tags, the ClickZip chelates can be released from (biological) samples by acidic hydrolysis, chromatographically distinguished from interfering lanthanide species, and sensitively detected by mass spectrometry. Lanthanides enclosed in ClickZip chelates are chemically almost indistinguishable, providing a more versatile alternative to chemically identical isotopic labels for multiplexed analysis. The bioanalytical potential is demonstrated on tagged cell-penetrating peptides in vitro, and anti-obesity prolactin-releasing peptides in vivo.
Outlier detection and removal in multifractal analysis of electrophysiological brain signals
Authors: Dumeur Merlin , Palva J. Matias , Ciuciu Philippe
Published: March 2024

The analysis of the scale invariant properties of brain activity has received growing attention in the last 15 years, especially in the context of the brain criticality hypothesis.Multifractal analysis (MFA) extends the ability of usual tools in brain criticality research (e.g. Detrended Fluctuation Analysis) to characterize scale invariance, by investigating the scaling of higher order statistical moments. However MFA is very sensitive to the presence of outliers in the data, for instance in the form of impulsive noise.In this work, we propose a novel algorithm for outlier detection and removal, which relies on the wavelet p-leader MFA formalism. The proposed approach consists in temporally segmenting the time-scale representation of the data (time series), and then tagging and removing the outlier segments from the final MFA estimation process. We first compare on on synthetic noisy mono- and multifractral time series the performances of our method with those of existing techniques such as the wavelet $p$-leader MFA formalism and a naive robust cumulant based approach. The proposed method is then evaluated on a single noisy resting-state Magnetoencephalography (MEG) recording of a healthy volunteer. Overall we show that in the presence of noise impulses, this method removes the existing bias with standard MFA tools (wavelet-leader based analysis) on both synthetic and neurophysiological data, with consistent findings across the two brain hemispheres in MEG.
Identifying General Reaction Conditions for Mechanoradical Natural Hydrogen Production
Authors: Liang Yunfeng , Cui Wuge , Masuda Yoshihiro , Hirose Takehiro , Tsuji Takeshi
Published: March 2024

Natural hydrogen is widely distributed, and its generation from rock and water is poorly known on the molecular scale. Here, we provide direct experimental evidence of hydrogen production from rock and offer an atomistic insight into the natural hydrogen origin based on first-principles molecular dynamics simulation using quartz as the model silicate mineral. The hypothetical reaction pathway of mechanoradical hydrogen generation is clarified, and the reductive environment and deprotonation process are shown to be essential for hydrogen generation. Hydrogen was generated from Si radicals and H2O in two steps involving charge transfer and inverse charge transfer. Oxygen generation was also observed in experiments and simulations, it was generated on an oxygen-rich surface with SiOO as an intermediate product. Simulations using water and ice VII (a high-pressure form of water) at different temperatures link our results to potential natural hydrogen production conditions.
Exercise Intolerance in Long Covid After 24 Months From Severe Acute Disease: is There Room for Improvement?
Authors: Borges Fernanda Facioli dos Reis , Braga Andrezza Cristina Barbosa , Viana Bernardo Silva , Valente Jefferson , Bemfica João Marcos , Motta Thais Jordão Perez Sant'Anna , Fernandes Eduardo , Goulart Cassia da Luz , Almeida-Val Fernando , Arêas Guilherme Peixoto Tinoco
Published: March 2024

Introduction: Long COVID is a complex and multisystemic condition, where dyspnea, fatigue, post-exertional malaise, cognitive impairment, decreased functional capacity, and deterioration in quality of life are the most incident clinical features. Few studies have reported cardiopulmonary alterations 24 months after severe COVID-19 infection.
Objective: to evaluate the functional capacity of individuals with persistent symptoms after severe COVID-19 infection compared to control individuals without symptomatic COVID or mild COVID after 24 months.
Methods: This is a case-control study assessing 34 individuals divided into 2 groups (severe COVID-19 with long COVID and a control group consisting of asymptomatic/mild acute COVID-19 with no long COVID) regarding functional capacity by 6-minute walk test (6MWT) associated with gas analysis, spirometry, respiratory muscle strength and quality of life. Results: During the 6MWT, an important lower heart rate (HR) was observed for the COVID group, with greater exertional perception, a significant decrease in the distance covered, and a low value of O2 uptake (V̇O2) and minute ventilation, in addition to very low quality of life scores, especially in aspects of functional capacity and physical limitations.
Conclusion: individuals who have severe COVID-19 and persist with symptoms have low functional capacity, low V̇O2, low HR behavior, and low quality of life.
Post-repair seismic assessment of steel MRFs prone to soft-story mechanisms using rocking walls: cost-performance analysis
Authors: Dehcheshmeh Esmaeil Mohammadi , Ahmadi Milad Hooshyar Soltan , Broujerdian Vahid , Jafari Abouzar
Published: March 2024

Coupling a rocking wall with a moment-resisting frame (MRF) is a viable and practical solution to mitigate the risk of soft-story mechanisms. However, little research has been conducted to investigate the retrofitted MRFs’ post-repair performance and the cost-performance of intervention. This research conducted a numerical parametric study to assess the cost-effectiveness of the retrofitting approach and shed light on the seismic performance of the retrofitted frames. To this end, three steel benchmark MRFs (i.e., three-, six-, and nine-floor height implicitly representing low-, mid- and relatively high-rise buildings, respectively) were selected, and pinned constraints were applied to the end of frames columns to induce the soft-story mechanism. Through coupling a base-rocking wall to the benchmark MRFs, thirteen different retrofitted scenarios were created considering different height and stiffness for the wall. Risk and performance assessment and seismic fragility analysis of the retrofitted scenarios were conducted by performing pushover and incremental dynamic analysis. The cost of retrofitting was estimated for each scenario, and a performance index was introduced to evaluate the efficiency of retrofitting intervention and, after that, to conduct a cost-performance analysis. The results showed that the retrofitting approach considerably decreases residual drift, especially in low-rise buildings. The best performance was achieved in low-rise buildings, and the retrofitting efficiency decreased by increasing the building’s height. Increasing the attached wall’s height has a stronger effect on reducing the retrofitted scenarios’ collapse probability. Besides, increasing the height of the attached wall has a more pronounced effect than stiffness in improving the safety and inter-story drift uniformity of retrofitted scenarios. In terms of performance, for low-rise buildings, employing a less stiff wall leads to a better result, although for mid- and high-rise buildings, scenarios with longer and stiffer wall greatly outperform others. In terms of cost-effectiveness, using a shorter and less stiff wall outperforms other scenarios by a large margin.
Efficacy and Safety of Anisodamine Hydrobromide Combined with Low-molecular-weight Heparin for the Treatment of Sepsis Patients: Study Protocol for a Multicenter Randomized Controlled Trial
Authors: Chen Ying , Wei Shuxing , Dong Hongmeng , Ji Wenqing , Zhang Da , Xu Yali , Zhou Haijiang , Mei Xue , Guo Shubin
Published: March 2024

The objective of this study was to compare the effects of traditional treatment with those of anisodamine hydrobromide (Ani HBr) combined with low-molecular-weight heparin (LMWH) in the treatment of sepsis in hopes that this therapy will provide alternatives for the treatment of sepsis. This was a randomized, placebo-controlled, open-label, multicenter trial involving patients with sepsis recruited from seven emergency departments in Beijing, China. Patients diagnosed with sepsis will be randomly assigned to either the treatment or control group at a 1:1 ratio. The treatment group will receive Ani HBr combined with LMWH, while the control group will receive conventional treatment. A total of 782 sepsis patients will be recruited, and interim analysis will be conducted. The primary endpoint of the study was the 28-day mortality rate. The secondary endpoints included the lactate clearance rate at 6 hours, 24 hours, and 72 hours, the duration of ICU and hospital stay, the number of days without organ failure, the number of days with vasopressor use within 28 days, the septic shock conversion rate, the 28-day mortality rate of septic shock, and the 72-hour sublingual microcirculation. If the combination therapy of Ani HBr and LMWH demonstrates superior efficacy compared to conventional treatment, this study will provide valuable insights into the treatment of septic shock and potentially contribute to reducing the mortality rate associated with this condition.
Trial registration:NCT05634057 (https://register.clinicaltrials.gov/).
Predictive Analysis of the Leptin-Melanocortin and Adiponectin Signaling Pathways in Obesity through In Silico Techniques
Authors: Ghosh Sunandini , Dhar Shrinjana , Roy Ushashi , Mondal Sayan , Bhattacharjee Pritha
Published: March 2024

Genetic and epigenetic alterations have been reported to significantly influence the global burden of obesity. Single nucleotide polymorphisms (SNPs) including both coding and non-coding amino acid changes are the key regulators of the protein structural and functional modifications. The current computational study utilizing in silico techniques focused on the screening and identification of the most pathogenic missense SNPs of the selected candidate genes of the leptin-melanocortin and adiponectin signaling pathways provoking obesity. A total of 2424 SNPs from 9 candidate genes were extracted from the NCBI database followed by pathogenicity prediction using seven servers, SIFT, PANTHER, Meta-SNP, PhD-SNP, PredictSNP, PolyPhen-2, and SNAP2. The shortlisted variants (n = 7) were analyzed for structural stability using DynaMut, iMutant, INPS3D, MuPro, and iStable followed by the functional stability analysis (n = 3) using Mut-Pred2, Project HOPE, and I-TASSER. Gene-network analysis of the finally screened SNPs (n = 3) was created using the STRING database. Two SNPs of ADIPOR1 (rs1419320091 and rs1654109863) and one variant of MC4R (rs1159323398) were predicted in the study to be the most pathogenic resulting in altered protein functionality. Therapeutic approaches designed based on early pathogenicity predictions using in silico analysis techniques would be a new horizon for the effective control of disease prevalence.
A variety of methods to determine the accumulation period of tight gas reservoirs in the Upper Paleozoic of Ordos Basin
Authors: Chen Zhanjun , Gao Xiaoping
Published: March 2024

There is no unified view on the formation period of Upper Paleozoic gas reservoirs in Ordos Basin, China. This study takes Yulin area located in Yishan slope of Ordos Basin as an example, and comprehensively determines the period of gas accumulation through various methods. The study process includes : Firstly, according to the geological background and accumulation model, the idea of accumulation period analysis is established. Secondly, the necessary key parameters for the accumulation period are put forward. Thirdly, the burial history of strata, the dynamic characteristics of hydrocarbon generation of source rocks and the dynamic change of hydrocarbon content in reservoirs are studied. The key necessary parameters required for the study are obtained through the above process. Finally, according to these parameters, each time node in the accumulation process is determined, and then each accumulation period is determined. The results show that the Upper Paleozoic in Yulin area is ' three periods of hydrocarbon generation and two periods of hydrocarbon accumulation '. The three periods of hydrocarbon generation occurred in the Triassic ( -229 Ma ~ -200 Ma ), Jurassic ( -188 Ma ~ -151 Ma ) and Early Cretaceous ( -138 Ma ~ -100 Ma ). The intensity of hydrocarbon generation in each period increases in turn. The two periods of hydrocarbon accumulation occurred in Late Jurassic ( -178.5 Ma ~ -151 Ma ) and Early Cretaceous ( -138 Ma ~ -100 Ma ). The late Early Cretaceous ( -126.7Ma ~ -100 Ma ) is the main accumulation period. In order to avoid the application defects of various methods in this area, the research work uses the determined parameters obtained by every single research method. According to each accurate parameter analysis, the start time of hydrocarbon generation, the start time and end time of gas reservoir, and the time of each period of accumulation are obtained. This research process eliminates possible errors in the research process and ensures the credibility and accuracy of the research results.
Optimal Scheduling of Agricultural Machines in Hilly Mountainous Areas Based on NSGA-II-SA Hybrid Algorithm with Applications
Authors: Liu Huanyu , Luo Jiahao , Zhao Baidong , Zhang Lihan , Wang Fulin , Wang Shuang
Published: March 2024

Optimizing the scheduling of farm machinery is essential to meet farmers' requirements, minimize scheduling costs, and save time. This study focuses on scheduling farm machinery in multiple cooperatives across various regions, aiming to minimize scheduling costs and reduce scheduling time. Initially, a multi-constraint hybrid clustering algorithm is employed to assign farmland to each farm machinery cooperative by clustering before scheduling. Subsequently, an enhanced version of the Non-dominated Sorting Genetic Algorithm-II (NSGA-II) is proposed, integrating a local search strategy based on congestion-based neighborhood search and the Simulated Annealing (SA) algorithm to develop the NSGA-II-SA algorithm. This hybrid multi-objective evolutionary algorithm effectively optimizes scheduling costs and time. The model's validity and the algorithm's superiority are demonstrated through a Web-based multi-region agricultural machine scheduling system and an example study. Experimental results show that the NSGA-II-SA algorithm significantly reduces scheduling costs and time, as well as the number of dispatched farm machines, outperforming other algorithms with reductions of 9.8%, 3.1%, and 8.7% in total scheduling costs, and 12.5%, 13.4%, and 11.6% in total scheduling time. This research establishes a theoretical framework for multi-region agricultural machine scheduling in hilly and mountainous areas, enhancing agricultural production efficiency.
Revealing reaction intermediates in one-carbon elongation ThDP/CoA dependent enzyme family
Authors: Joachimiak Andrzej , Kim Youngchang , Lee Seung Hwan , Gade Priyanka , Nattermann Maren , Maltseva Natalia , Endres Michael , Chen Jing , Wichmann Philipp , Hu Yang , Marchal Daniel , Yoshikuni Yasuo , Erb Tobias , Gonzalez Ramon , Michalska Karolina
Published: March 2024

2-Hydroxyacyl-CoA lyase/synthase (HACL/S) is a thiamine diphosphate (ThDP)-dependent versatile enzyme originally discovered in the mammalian α-oxidation pathway. HACL/S natively cleaves 2-hydroxyacyl-CoAs and, in its reverse direction, condenses formyl-CoA with aldehydes or ketones. The one-carbon elongation biochemistry based on HACL/S has enabled the use of molecules derived from greenhouse gases as biomanufacturing feedstocks. We investigated several HACL/S family members with high activity in the condensation of formyl-CoA and aldehydes, and distinct chain-length specificities and kinetic parameters. Our analysis revealed the structures of enzymes in complex with acyl-CoA substrates and products, several covalent transition states, bound ThDP and ADP, as well as a previously unseen C-terminal active site region. One of these new states corresponds to the intermediary α-carbanion with ThDP covalently attached to formyl- CoA. This research distinguishes HACL/S from related sub-families and identifies key residues involved in substrate binding and catalysis. These findings expand our knowledge of acyloincondensation biochemistry and offer new prospects for biocatalysis using carbon elongation.