bluuebunny/crossref_metadata_2025 huggingface dataset:
Cuidado de Enfermagem à Idosa com Síndrome da Fragilidade fundamentado na Teoria do Conforto
Authors: Fonteles Lucena Sarah Lídia , Silva Farias Fernanda , Malaquias Cordeiro Lucélia , Reis Coutinho Daisy Teresinha , Da Silva Lucia De Fatima , De Freitas Maria Célia
Published: June 2022

Objetivo: descrever resultados e intervenções/atividades de Enfermagem para a idosa com o Diagnóstico de Enfermagem Síndrome do Idoso Frágil, fundamentado na Teoria do Conforto. Método: Estudo de caso clínico, realizado com idosa com o Diagnóstico de Enfermagem síndrome do idoso frágil, residente de Instituição de Longa Permanência. Resultados: Os resultados, intervenções de enfermagem planejadas foram fundamentadas na Classificação dos Resultados de Enfermagem e Classificação das Intervenções de Enfermagem. Conclusão: Considera-se relevante a aplicabilidade da linguagem de enfermagem na prática clínica do enfermeiro com vista a firmar a identidade da profissão.Descritores: Enfermagem; Idoso; Fragilidade; Instituição de Longa Permanência para Idosos; Teoria de Enfermagem.NURSING CARE FOR ELDERLY WOMEN WITH FRAGILITY SYNDROME BASED ON COMFORT THEORY Objective: To describe Nursing results and interventions / activities for the elderly with the Nursing Diagnosis of the Frailty Elderly Syndrome, based on Comfort Theory. Methods: Clinical case study, carried out with an elderly woman with fragile elderly syndrome, resident of an Long Term Elderly Care Institution. Results: The nursing interventions were based on the classification of nursing outcomes and classification of nursing interventions. Conclusion: The applicability of the nursing language it’s considered relevant in the clinical practice and helps establish the identity of the nursing profession. Keywords: Nursing; Aged; Frailty; Homes for the aged; Nursing theory. CUIDADO DE ENFERMERÍA A MUJER ADULTA MAYOR CON SÍNDROME DE FRAGILIDAD BASADO EN LA TEORÍA DE LA COMODIDAD Objetivo: Describir los resultados de las intervenciones/actividades de Enfermería dirigidas a la anciana con diagnóstico de Enfermería síndrome del anciano frágil, una base en la teoría de la comodidad. Métodos: Estudio de caso clínico, realizado en anciana con diagnóstico de Enfermería síndrome del anciano fragil, residente de Instituciones de larga estancia para personas de edad. Resultados: Los resultados, las intervenciones / la actividad de enfermería planificada se basaron en la clasificación de los resultados de enfermería y la clasificación de las intervenciones de enfermería. Conclusión: Se considera relevante la aplicabilidad del lenguaje de enfermería en la práctica clínica de la enfermera con el fin de reafirmar la identidad de la profesión. Descriptores: Enfermería; Anciano; Fragilidad; Hogares para ancianos ; Teoría de enfermería
Reminiscências da primeira mestra de d. Pedro II: Mariana Carlota de Verna
Authors: Vasconcelos Maria Celi Chaves , Rodrigues da Cunha Gilmara
Published: June 2022

O estudo aborda a trajetória de Mariana Carlota de Verna como primeira mestra de d. Pedro II, e o que a levou, posteriormente, a receber o título de condessa de Belmonte. O objetivo central é evidenciar as circunstâncias em que assumiu o cargo de preceptora do herdeiro do trono do Brasil e algumas das dificuldades que enfrentou para se manter nele até a maioridade do soberano. Em um plano mais específico, buscou-se as suas menções nos periódicos da época, analisando-se como ela era vista e retratada na sociedade oitocentista do Segundo Reinado. Os procedimentos metodológicos remetem a uma pesquisa histórico e essencialmente documental, cujas fontes foram, em grande parte, consultadas no Arquivo Pessoal de um descendente da condessa, além de recolhidas em periódicos da hemeroteca da Biblioteca Nacional e em estudos já realizados sobre ela. Conclui-se que Mariana Carlota de Verna possuía uma forte influência sobre o imperador, embora tenha mantido certa discrição em relação a sua posição, sendo considerada a referência de afeto maternal para d, Pedro II.
The Irreversible Inhibition of Aromatase	(Oestrogen Synthetase) by Steroidal Compounds
Authors: Lombardi Paolo
Published: June 2022

Approximately one-third of the over 100,000 annual new breast carcinoma cases in the USA are classified as hormone-dependent. In patients with hormone-responsive neoplasms, the withdrawal of oestrogens or the alteration of oestrogens action result in tumour regression. In the last three decades clinical investigation has focused on the inhibition of oestrogen biosynthesis, since aromatase (oestrogen synthetase) is the rate-limiting enzyme in the conversion of androgens to oestrogens. More recently, aromatase became the target enzyme of specifically designed, mechanism-activated inhibitors. Such compounds should have high affinity for the enzyme, longer duration of pharmacological action, since their inactivation results by a covalent binding of the .inhibitor to the
enzyme, and consequently they should show reduced toxicity with respect to both hormonal and non- .
hormonal agents currently clinically available. 4-Hydroxyandrost-4-ene-3,17-dione (3), the first potent 'mechanism-based inhibitor identified, entered the market in 1993. A variety of promising compounds are currently following in advanced clinical trials. This review will update efforts toward the discovery and the synthesis of mechanism-based steroidal inhibitors of aromatase, with emphasis on those with proven efficacy in the animal, and with particular relevance to those which
appeared solely in the patent literature.
Mechanism of Action-Governed Design of Anthracycline Antibiotics: A "Turn-Off/ Turn-On" Approach
Authors: Priebe Waldemar
Published: June 2022

We present a novel approach to the design of more effective anthracyclines based on structUre­ mechanism of action relationships rather than on classical structure-activity relationships . The core of this approach is first, the identification of structural elements critical for a particular mechanism of action and then, the use of chemical modifications to "tum off ," or reduce participation of, certain mechanism s while "turning on," i.e., maintaining or increasing participation of, the desired mechanism. Subse-quently , this approach will lead to a better understanding of the molecular interaction of anthracyclines with targets . To illustrate the potential of this approach for anthracycline s, we focus on chemical alterations that can tum · off P-glycoprotein-mediated efflux and in consequence allow circumvention of multidrug resistance without suppressing the drug's ability to inhibit topoisomerase II. We review the mechanistic effects of
deamination and decreased basicity, as well as their biological relevance. Particularly, we concentrate on .
the effects of amino group removal from C-3' and replacement with a hydroxy group, a change that leads to increased activity against multidrug-resistant tumors in vitro and in vivo . Using this approach, we have selected and developed Annamycin, a new drug with clearly altered mechanisms of action that is currently undergoing phase I clinical evaluation.
Impaired Accumulation of Drug in Multidrug Resistant Cells. What are the Respective Contributions of the Kinetics of Uptake and of P-Glycoprotein­ Mediated Efflux of Drug?
Authors: Gamier-Suillerot Arlette
Published: June 2022

Up to now , the only h ope to cure systemic cancers such as leukemia and lymphoma and unifocal tumours that have spread by metastasis resides in systemic treatment s such as chemotherapies and Immunotherapies. Unfortunately, the appearance of cell populations resistant to multidrug-based chemotherapy constitutes the major problem to achieve cures in the patients. Multidrug resistance (MDR) confers upon cells ability to withstand exposure to lethal doses of many structurally unrelated antmeoplast1c agents. MDR IS assocm ted w1th decreased drug accumulation resulting from enhanced drug efflux. This is correlated with the presence of a membrane protein, P-glycoprotein, which pump s drugs out of cells thus reducing their cytotoxicity. The search for new compounds able to overcom e MDR is of prime importanc e in the clinic . One of the strategies to reverse MDR is based on the design
an synthesis of non-cross-resistant analogs of MDR drugs. The activity of a drug depend s upon its intracellular concentration which Itself depend son the kmet1csof influx and efflux of the drug across the cell membrane . Analysis of the literature and our own data show that m the drug design of new antitumor drugs able to overcome MDR , it seems more efficient to consider the modulation of the parameter s that will lead to an increase of the kinetics of uptake than those which could lead to a lowering of the kinetics of the P-gly coprotein-mediated efflux.
Anthracyclines - Pharmacology and Resistance, A Review
Authors: Bakker M . , van  der  Graaf W.T.A. , Groen H.J.M. , Smit E.F. , De Vries E.G.E.
Published: June 2022

Anthracyclines are anti-tumor drugs with a wide spectrum of activity in human cancers. Th.ey were introduced in clinical practice in the early 1960's and have been extensively used in the adJuvant, curative and palltatlve settmg for both soltd tumors and hematologic malignancies. Their mechanisms of action have not yet been fully clarified. The best known cellular mechanisms are prevention of replication and transcription by intercalation of DNA , formation of DNA breaks possibly due to formation of tox1c topmsomerase complexes, and generation of free radicals. Pharmacokinetic studies revealed that anthracyclines dissappear fast from the plasma into tissues. Cellular uptake takes
place b_Y d1ffuswn; efflux can take place by ener y-dependent membrane pumps. The intracellular concentration seems a major determmant for the cytotox1c effect. Anthracychnes are reduced to more hydrophilic glycide metabolites and aglycones. The drug .Js excreted vw the b1le and for a mmor degree v1a the unne. The cltmcal value of anthracyclines is limited by intrinsic or acqmred tumor cell resistance to anthracycltnes. D1fferent ways of resistance seem to play a role in multidrug resistance (MDR) such as the overexpression. of the membrane efflux pump P-glycoprotein , as well as th e overexpression of the multidrug res1stance associated protem (MRP) or probably other efflux pumps , a decrease in the activity of the target enzyme topoisomerase II and an .increase in cellular detoxifyin,g. capacity. Resistance against anthracyclines as well as early (myelosuppressiOn , mucosil!S) and late tox1c!ly (cardJOtOXJCity) have directed the search for analogs with higher antitumor efficacy and lower toxicity. This search delivered variants of the original daunorubicin such as epirubicin and idarubicin with a more favorable therapeutic index , and morpholino anthracyclines, drugs designed to circumvent P-glycoprotein and non P­ glycoprotem MDR. These last compounds recently enrolled phase IIII clinical trials . Results of these trials are of even more interest because up t now, results of clinical studies in solid tumors with modulators (resistance modifiers) of MDR , such as amwdarone, verapmml , cyclosponn A and PSC 833 are not very encouraging. In vivo studies with e.g. PET scanning to analyse the mtratumor kmellc behavior of anthracycltnes and modulators of drug resistance, are ongoing .
Synthesis and Preliminary Biological Evaluation of New Phthalazinone
Derivatives with PARP-1 and Cholinesterase Inhibitory Activities
Authors: Min Zhenli , Lin Yu , Gao Chengzhi , Wang Zhuyong , Zhang Ruifeng , Chen Yajun
Published: June 2022

Background:

Alzheimer's disease (AD) is the most common brain disorder and remains a major
health concern worldwide. Considering the highly complex mechanisms of AD, the search for agents
based on a multitarget-directed ligands (MTDLs) strategy to treat AD may be more promising than the
traditional “one drug-one target” strategy. Inhibition of Poly (ADP-ribose) polymerases-1 (PARP-1) has a
potentially therapeutical effect on AD. Therefore, it is worthy to investigate compounds that target both
PARP-1 and cholinesterase, which perhaps produces new agents against AD.

Objective:

To search for new agents with PARP-1 and cholinesterase inhibitory activities for the treatment
of AD.

Methods:

A series of 21 novel compounds incorporated the respective pharmacophores of two marketed
drugs, namely the 4-benzyl phthalazinone moiety of a PARP-1 inhibitor, Olaparib, and the Nbenzylpiperidine
moiety of an AChE inhibitor, Donepezil, into one molecule was synthesized. The inhibitory
activities of all the synthesized compounds against the enzymes PARP-1, acetylcholinesterase
(AChE) and butyrylcholinesterase (BChE) were evaluated. The binding modes of the most potent compound
inside the PARP-1 and the human BChE (hBChE) were investigated by molecular docking.

Results:

N-((1-(4-fluorobenzyl)piperidin-4-yl)methyl)-2-fluoro-5-((1, 2-dihydro-1-oxophthalazin-4-
yl)methyl)benzamide (30) exhibited the most potent inhibitory effect on PARP-1 enzyme
(IC50=8.18±2.81nM) and moderate BChE inhibitory activity (IC50=1.63±0.52μM), while its AChE inhibitory
activity (IC50=13.48±2.15μM) was weaker than Donepezil (IC50=0.04±0.01μM). Further molecular
docking studies revealed that four hydrogen bonds were formed between 30 and PARP-1, meanwhile, 30
interacted with the critical residues His438 and Trp82 of hBChE through hydrogen bonds and hydrophobic
interactions, which were necessary for hBChE inhibitory potency.

Conclusion:

A new compound with potent PARP-1 inhibitory activity and moderate BChE inhibitory
activity was obtained, which merited to be further investigated as an anti-AD drug. The studies gave a
clue to search for new agents based on PARP-1 and cholinesterase dual-inhibited activities to treat AD.
Synthesis, Molecular Docking, and In vitro Antimycobacterial
Studies on N'-arylidene-4-nitrobenzohydrazides
Authors: Bhosale Dinesh , Mali Suraj N. , Thorat Bapu R. , Wavhal Swati S. , Bhagat Devidas S. , Borade Ravikumar M.
Published: June 2022

Background:

Mycobacterium tuberculosis (Mtb) is the organism that causes tuberculosis to develop (TB). In 2019, 10 million individuals worldwide contracted tuberculosis, with 1.4 million people dying from the disease each year (World Health Organization, 2021). Hydrazones-hydrazide-based drugs have been shown to be bactericidal against M. tuberculosis replication.

Objectives:

We herein intended to synthesize a series of acid hydrazones (3a-3l) by condensing 4-nitrobenzohydrazine with substituted aromatic acids in ethanol at room temperature.

Materials and Methods:

All newly synthesized compounds were characterized by standard spectroscopic techniques. Synthesized compounds were then tested for anti-mycobacterial analysis, H37Rv strains. Molecular docking analysis was performed for three crystal structures of 1ENY, 1TED and 2FUM Mycobacterium tuberculosis receptors.

Results:

Among all tested molecules, 3i (MIC: 50 μg/mL) and 3b (MIC: 50 μg/mL) were found to best ligands for further development of new anti-TB drug. We noticed that our proposed molecules were having higher docking scores that corresponding standard anti-TB agents such as Ciprofloxacin and Isoniazid. Synthesized compounds were found to have Drug-Likeness properties when tested with Lipinski’s filter for drug-likeness.

Conclusion:

From our current study, we wish to propose N'-arylidene-4-nitrobenzohydrazides as anti-TB agents. Agents with such system can be developed in future for developments into active lead molecules.
Application of Artificial Intelligence for Designing Cancer Nanomedicine
Authors: Dilnawaz Fahima
Published: June 2022

Precision cancer medicine deals with the selection of anticancer drugs for treatment that is appropriate for the tumor's molecular profile and that of the tumor microenvironment. Further, the process of drug development and efficacy analysis becomes tedious with an improved understanding of genetic profile and pattern. In this regard, artificial intelligence (AI) has demonstrated enormous potential in several areas of the healthcare sector that deal with data analysis and drug discovery. AI has extended towards improving therapeutic efficacy with the integration of AI-based tools into the cancer care regime. Importantly, with the application of AI algorithms, the gene mutations' impact on the sensitivity of chemotherapy or radiation therapy can be predicted. AI-assisted drug identification involving virtual screening of the drug safety and efficacy is relatively cost-effective and time-saving.
Strengthened Common Security and Regional Interdependence in European Union: From Brexit to Covid-19 Pandemic
Authors: Savitri Rohannisa Naja Rachma
Published: June 2022

The results of Brexit referendum have led to a differentiation in terms of decisions and responds between leaders in the European Union about the future of this regional organization. As a result, the European Union was divided into two groups which is “more Europe” and “less Europe” as it hinders in reaching consensus regarding the formulations of a policy in the European Union. This research uses the theory of Interdependence and common security to analyze European Union’s responds to Brexit and COVID-19 where the compilation of the analysis’ results was carried out using qualitative methods and an explanatory approach. In fact, the COVID-19 Pandemic brought a negative impact in many fields that can destabilize not only member countries, but also regional security in Europe. The results of this research indicate that the European Union, which was heading towards disintegration due to Brexit, was able to set aside fragmented national interests by increasing interdependence to achieve common security in the European Union due to the COVID-19 Pandemic. This interdependence is proven by holding meetings and a common viewpoint on the threat of Covid-19, so that policy formulation can be carried out comprehensively and responsively.
E-Commerce Boom and Consumer Culture amidst COVID-19 Pandemic: Delineating Indonesia’s Purchasing Pattern
Authors: Istiqomah Citra
Published: June 2022

Global trade transformation and technological advancement drive business sector into another level we have never imagined and alter people’s daily lifestyle. However, with the occurrence of global pandemic, the world is forced to make a few steps backwards as the economy in most countries see a downturn. Surprisingly, e-commerce set a new adoption of business pattern and lifestyle, and even pushes consumerism to leap forward as people comply with stay-at-home measures. COVID-19 crisis has indeed caused a structural shift towards digital commerce, but the cultural impact is just as powerful. This study would like to delineate particular cases of e-commerce and retail development in Indonesia through mapping consumers’ purchasing pattern as well as current challenges for both people and businesses. The findings suggest that culture can affect business in terms of segments, choices based on latest trends and common belief. In Indonesian case, segmentation is shifting from travel to home-based activities and interest. Yet, preferences on specific trends and lifestyle remain unchanged, for example, younger generation inclination to products of Korean popular culture and products with halal certification. This pinpoints that consumer behaviour and cultural background have to be seriously taken into account for businesses to develop. Albeit it is crucial for business players to turn their attention to this, government has to be able to encourage the growth of the overall landscape by providing an ease into business environment through physical and digital infrastructure assistance in order to create competitive and inclusive milieu in this digital economy era.
Risk Factors Associated with Treatment Default Among Tuberculosis Patients in Adamawa State, Nigeria
Authors: Okoro Charles , Bamigbala Olateju Alao , Ojetunde Ayodeji Oluwatobi , Ibrahim Abdulmudallib
Published: June 2022

Background. Tuberculosis is an infectious disease caused by bacteria called Mycobacterium tuberculosis. The treatment of drug-resistant tuberculosis is complex, costly, and usually has poor outcomes. Treatment default is well known as a very significant factor associated with drug-resistant tuberculosis.

The aim of this study was to investigate the hazard ratios associated with treatment default among tuberculosis patients in Adamawa State, Nigeria.

Materials and Methods. The Cox proportional hazards regression was used to determine the hazard ratios associated with tuberculosis patient treatment default in Adamawa State, Nigeria. The Kaplan-Meier method was used to analyze time-to-event data. The study assessed the survival status and treatment outcomes of tuberculosis patients over a six-month period (January 2019 to June 2019). Data analysis was done using R - Programming Software and the statistical significance was considered at p < 0.05.

Results. Out of the 197 (124 males and 73 females) tuberculosis patients, 148 (75.1%) individuals were diagnosed with pulmonary tuberculosis and 49 (24.9%) individuals were diagnosed with extrapulmonary tuberculosis. The treatment outcomes were as follows: 33 (16.8%) patients were cured; 36 (18.3%) individuals completed their treatment; 3 (1.5%) patients died during treatment; 105 (53.3%) subjects defaulted; 8 (4.1%) patients were lost to follow-up; the remaining 12 (6.1%) individuals were still on treatment at the end of the study. According to the Cox proportional hazards analysis, HIV-positive status (p < 0.05, 95% CI [0.361 - 0.879]), primary education level (p < 0.01, 95% CI [1.248 - 3.354]), poor quality of life (p < 0.01, 95% CI [1.239 - 3.511]) and age over 60 years old (p < 0.05, 95% CI [0.569 - 2.206]) were significant hazard ratios to experience the event (treatment default) in the study area.

Conclusions. This study revealed that HIV-positive tuberculosis patients, older patients, patients with primary education, and those with poor quality of life are significant risk factors to experience treatment default in the study area. Therefore, it is recommended that stakeholders managing the treatment and care of tuberculosis patients should be dedicated and intentional in the provision of psychosocial therapy to patients with poor quality of life.
The Mongoose Phenomenon: A New Logical Heuristic
Authors: Varkey Thomas C. , Varkey John A. , Sivakumar Milan , Merhavy Zachary I.
Published: June 2022

Often when discussing what is considered a rarer occurring event, individuals reference the Baader-Meinhof phenomenon as insurance against fallacious thinking. Also known as the frequency bias, this logical heuristic states that rare occurring events are rare and the knowledge of the existence of rare occurrences makes the interlocutor more likely to search out the event or see it occur more frequently. These false increases in observation frequency can logically be blamed, at least in part, on the interlocutor being made aware of the event existence. This Baader-Meinhof logical heuristic is often mis-utilized in the sciences to minimize the chances of rarer phenomena from being considered within a logical framework for the work up of a problem. This article presents a new logical heuristic, the “Mongoose Phenomenon” as a counter argument and presents it in the context of the fields of medicine, the hard sciences, engineering, and philosophy. It is the intention of the authors that this logical heuristic be utilized to improve the thought process of scientists, clinicians, and others to ensure the best thought process for the work up and creation of a solution for problems.
Development of a Web-Based Decision Aid and Planning Tool for Family Building After Cancer (Roadmap to Parenthood): Usability Testing
Authors: Benedict Catherine , Dauber-Decker Katherine L , Ford Jennifer S , King D'Arcy , Spiegel David , Schapira Lidia , Simon Pamela , Diefenbach Michael
Published: June 2022

Background

Owing to gonadotoxic cancer treatments, young adult female survivors often report uncertainty about their fertility, reproductive potential, and family-building options after treatment. Roadmap to Parenthood is a web-based decision aid and planning tool for family building after cancer.

Objective

As part of a patient-centered development process, this study evaluated the usability of the decision aid website to inform design modifications and improve user experience.

Methods

In total, 2 rounds of usability testing were conducted with the target population of young adult female cancer survivors. During the testing sessions, participants viewed the website twice; first, as a think-aloud exercise, and second, while a researcher interrupted at key points to obtain user feedback. Quantitative and qualitative data were collected to assess website usability. Quantitative measures included the System Usability Scale, WebQual, and eHealth Impact Questionnaire. An exit interview with open-ended questions gathered feedback on likes and dislikes and suggestions for improvement.

Results

Participants (N=10) were young adult women, with average age of 30.9 (SD 4.51) years, and average time since treatment was 4.44 (SD 3.56) years. Website usability scores improved on the System Usability Scale from “acceptable” in round 1 to “excellent” in round 2 after making design changes based on user feedback (scores of 68 and 89.4, respectively). WebQual scores showed similar improvement from round 1 to round 2 of testing (mean 5.6 to 6.25; range 1-7). On the eHealth Impact Questionnaire, the information and presentation of the website was perceived as comprehensive, easy to understand, and trustworthy. Participants also reported improved confidence to discuss and manage fertility and family-building issues and felt encouraged to play a more active role in managing their fertility. In all, 3 usability themes were identified from the qualitative feedback: ease of use, visibility and navigation, and informational content and usefulness. Overall feedback was positive, and participants reported intentions to use the decision aid website in the future. In total, 10% (1/10) of the participants reported negative emotions when learning about infertility risks and potential family-building challenges.

Conclusions

Website usability improved after design changes were made in response to user feedback. Young adult female survivors reported positive views about the website and indicated that the decision aid would be useful in decision-making about family building after cancer. Future studies will include further design modifications to consider the emotional experiences of users and any additional navigational features or content to optimize the ease of use and support provided by the tool.
Co-creation of a Serious Game About Radiotherapy: Participatory Action Research Study With Children Treated for Cancer
Authors: Cederved Catarina , Back Jon , Ångström-Brännström Charlotte , Ljungman Gustaf , Engvall Gunn
Published: June 2022

Background

Children with cancer who have to undergo radiotherapy can experience fear, because they have no prior knowledge of the treatment. One way of teaching children about the treatment and reducing their fear is to prepare them for it through serious games. Involvement of the end user in the design process within medicine is a way of ensuring that the product being developed will fit the intended user.

Objective

The aim was to outline the contributions made by children and their parents through participatory action research when designing a serious game about radiotherapy.

Methods

By means of participatory action research, children and their parents participated in the development of a serious game about radiotherapy. Nine children (7-10 years old) were included, each with an accompanying parent. A qualitative approach was used that included interviews and participant observation. Six rounds of iterative development process were used with the children and their parents. Meetings with the children were held either face-to-face or online. Each round resulted in a list of suggestions for changes to the game. A thematic analysis was performed based on the list of proposed changes, underpinned by all gathered data, to highlight how the children’s participation changed the game.

Results

Two main themes were identified. The first theme was “The children’s participation was affected by their health and treatment” and included the following subthemes: “an opportunity to share emotions and perceptions of radiotherapy” and “the possibility to participate was affected by the severity of the disease.” The second theme was “participation allowed becoming an active part of game development” and included the following subthemes: “the opportunity to express sentiments about the game,” “the emergence of a playable game through the children’s contributions,” and “the necessity of understanding the text.”

Conclusions

The method used in this study made the children active participants, and our results suggest that this method can be used by health care researchers to cocreate serious games with children. It is necessary to inform the children involved that the process takes time, and that the process can be altered to allow as much participation as possible without placing a burden on them. The children’s illness affected their possibility to take part; thus, it is crucial to accommodate the children’s needs when conducting similar studies. The parents’ participation facilitated the meetings for their children, even though their involvement in the game design was negligible.
Correction: Mobile Health–Based Thermometer for Monitoring Wound Healing After Endovascular Therapy in Patients With Chronic Foot Ulcer: Prospective Cohort Study
Authors: Lin Donna Shu-Han , Lee Jen-Kuang
Published: June 2022

In the “Patient Selection” section in Methods, “Patients with chronic foot ulcers were consecutively enrolled from the outpatient clinic or during admission from June 2019 to December 2019” should instead be “Patients with chronic foot ulcers were consecutively enrolled from the outpatient clinic or during admission from July 2019 to December 2019”. Similarly, in the “Methods” section in the Abstract, “Patients who had a chronic foot ulcer (>3 months) and underwent endovascular therapy between June 2019 and December 2019 were included” should read “Patients who had a chronic foot ulcer (>3 months) and underwent endovascular therapy between July 2019 and December 2019 were included”. Lastly, in the “Patient Demographics and Clinical Features” section in Results, “Between June 2019 and December 2019” should instead be “Between July 2019 and December 2019”.
Development of Nutrient Rich Value-added Biscuit through Incorporation of Orange-fleshed Sweetpotato Puree
Authors: Hossain M.M. , Heck S. , Chanda D. , Rahaman E.H.M.S. , Mahmood S. , Kabir M.H.
Published: June 2022

In Bangladesh bakery and confectionery industry has become almost self-sufficient in meeting the local demand. But the products produce from the factories cannot fulfill nutritional demand of the people of Bangladesh as wheat flour is the main ingredient of the bakery products. Orange Fleshed Sweetpotato is a promising root crop due to high beta carotene content and other vitamins and minerals could be used to reduce the gap of nutritional demand. The experiment was conducted with four BARI (Bangladesh Agricultural Research Institute) released orange fleshed sweetpotato varieties and a local cultivar at the GUK’s ‘Super Tasty Food’ Products Factory, Nashratpur, Gaibandha, Bangladesh during 2020-21 cropping season. The aim of the study was to develop nutrient rich value-added biscuit for the consumers. Eleven treatments (formulations) were used to develop biscuit. The highest amount of beta carotene content was recorded in T4 treatment (1.67 mg/100g) followed by T9 treatment (0.84 mg/100g) and the lowest was obtained from T11 treatment (0.01 mg/100g). Maximum amount of vitamin C detected in T5 treatment (1.81 mg/100g) which was statistically similar to T1 treatment (1.74 gm/100g) and no Vitamin C was found in T11 treatment. Zinc content found maximum in T11 treatment (2.04 mg/100g) while the lowest was observed in T5 treatment (1.12 mg/100g). The highest amount of iron was recorded in T3 treatment (6.52 mg/100g) which is significantly similar to treatment T2 (6.43 mg/100g) and T8 (6.09 mg/100g), respectively. The entire sensory attributes of value-added biscuit were accepted as fair to very good and have no remarkable difference from traditional biscuits (T11). The overall acceptability of the biscuit was found to be highest in T9 treatment (good to very good).
On the resolution of the heat equation in unbounded non-regular domains of R³
Authors: Boudjeriou Tahir , Khelouf Arezki
Published: June 2022

We will prove well posedness and regularity results for the bidimensional heat equation, subject to mixed Dirichlet-Neumann type boundary conditions on the parabolic boundary of an unbounded (in one space variable direction) time-dependent domain. Our results are proved in anisotropic Hilbertian Sobolev spaces by using the domain decomposition method. This work complements the results obtained in [13] in the one-space variable case.
Lyapunov stability and weak attraction for control systems
Authors: Rocha Victor H. L. , Reis Ronan A.
Published: June 2022

In this paper we deal with Lyapunov stability and weak attraction for control systems. We give characterizations of the stability and asymptotical stability of a compact set by means of its components. We also study the asymptotical stability of the prolongation of a compact weak attractor.
Spectral operation in locally convex algebras
Authors: El Boukasmi D. , El Kinani A.
Published: June 2022

We show that if A is a spectrally bounded algebra, then all functions operate spectrally on A if and only if SpAx is finite for every x ∈ A. We also prove that if A is a commutative Q-l.m.c.a, then all functions operate spectrally on A if and only if A/RadA is algebraic. Furthermore, if A is a semi-simple commutative Q-l.m.c.a. which is a Baire space, all functions operate spectrally on A if and only if it is isomorphic to Cn for some n ∈ N. A structure result concerning semi-simple commutative complete m-convex algebras of countable dimension is also given.
Development of a New Modelling Approach and Performance Evaluation of Meta-heuristic Optimization Algorithms for the Prediction of Kinetic Growth Parameters for Pseudomonas spp. in Fish
Authors: Tarlak Fatih , Yucel Ozgun , Khosravi-Darani Kianoush
Published: June 2022

The main aim of the current work was to build up a new mathematical modelling approach in predictive food microbiology field for the prediction of growth kinetics of microorganisms. For this purpose, the bacterial growth data of Pseudomonas spp. in whole fish (gilt-head seabream) subjected to isothermal and non-isothermal storage temperatures were collected from previously published growth curves. Maximum specific growth rate (1/h) and lag phase duration (h) were described as a function of storage temperature using the direct two-step, direct one-step and inverse dynamic modelling approaches based on various meta-heuristic optimization algorithms. The fitting capability of the modelling approaches and employed optimization algorithms was separately compared, and the one-step modelling approach for the direct methods and the Bayesian optimization method for the used algorithms provided the best goodness of fit results. These two were then further processed in validation step. The inverse dynamic modelling approach based on the Bayesian optimization algorithm yielded satisfactorily statistical indexes (1.02 > Bias factor > 1.09 and 1.07 > Accuracy factor > 1.13), which indicates it can be reliably used as an alternative way of describing the growth behaviour of Pseudomonas spp. in fish in a fast and efficient manner with minimum labour effort.
Serum Levels of Chemokine Ligand-7 and Interferon-γ-induced Protein-10: Possible Severity and Prognostic Markers in Patients with COVID-19
Authors: Hassan Rania Ahmed , Khattab Mona A. , Ezzelregal Hieba Gamal , Tawfik Heba Mohamed , Gadallah Shimaa Hussien , Abdelhamid Dalia Hosni , Ahmed Yasmin Mohamed
Published: June 2022

Patients with coronavirus disease-19 (COVID-19) present as mildly, moderately, or severely and critically ill. Cytokine storm is responsible for fatal pneumonia and acute respiratory distress syndrome. Interferon-γ-induced protein-10 (IP-10) and chemokine ligand-7 (CCL-7) are chemokines that play a role in the chemotaxis of inflammatory cells and the release of pro-inflammatory cytokines. In this study, we assessed the serum levels of IP-10 and CCL-7 chemokines in COVID-19 patients and their correlation with disease severity and prognosis. The serum levels of CCL-7 and IP-10 were assessed in 67 COVID-19 patients and 10 healthy controls. Serum samples were collected and examined for these two markers using direct enzyme-linked immunosorbent assay. Patients were divided into two groups according to their disease severity. Serum levels of the test markers were compared between patients and controls, and between patients with different disease severities and correlated with other clinical and laboratory parameters. CCL-7 and IP-10 levels were significantly higher in patients than in controls and in severe than in mild/moderate cases. The receiver operating characteristic curve analysis of the two markers showed better performance of the combined markers as predictors of disease severity (area under the curve = 0.792). The results of our study suggest a potential role of IP-10 and CCL-7 as predictors of COVID-19 severity.
Correlation of TNF-α, IFN-γ and TGF-β Expression with In-vitro Fertilization Success Rates in Women with Recurrent Implantation Failure Undergoing Treatment with Intra-lipid Infusion
Authors: Harby Islam Khaled Ali , Ahmed Ola Ibrahim , Zaki Wafaa K. , Faris Mohammed Ahmed , El-Deen Noha Nagi Salah
Published: June 2022

This study aimed at assessing the correlations between gene expression of TNF-α, IFN-γ, TGF-β in peripheral lymphocytes from women suffering from repeated implantation failure before and after intravenous Intra-lipid (IL) therapy, and correlation between changes in gene expression with IL infusion and success rate of IVF cycles. Twenty-three women complaining of unexplained infertility without history of autoimmune disorders, or immunodeficient diseases were included. All women included aged <40 years, BMI <28 with history of recurrent IVF cycles failure, seeking medical advice for new IVF trial. All were average responders to induction of ovulation (≥5 oocytes in each cycle) with good quality embryos transferred to uterus at proper time. Included women received 200 ml of 10% IL slowly intravenous. Two venous blood samples were taken from all candidates, one before IL infusion and the second was at day of embryo transfer. The current study detected a significant reduction of expression in TNF-α and increased expression of TGF-β, while non-significant reduction in expression of IFN-γ after treatment. Significant associations between reduction of TNF-α, IFN-γ expression and positive clinical and ongoing pregnancy were observed, while increased TGF-β expression was associated with only positive ongoing pregnancy. In conclusion, IL therapy might have a positive impact on IVF pregnancy rates via alterations in peripheral cytokines expression mainly reduction of TNF-α mRNA expression and increased TGF-β mRNA expression.
Image/Object Detection Using Shot Multi-Box Detector (SSMBD) Algorithm
Authors: Singh Vikash , Sainath Shalvi , Choudhary Tarun , Jain Risabh , Bajpai Rochak
Published: June 2022

Abstract: Object identification, is one of most important roles in computer vision, has been a hotspot for research and application over the past 20 years. Its purpose is to recognise and locate a large number of items in a given environment that fall into specific categories rapidly and consistently. It has gained a lot of study attention because of its tight association with image and video analysis. Its purpose is to discover and locate a large number of things in a given image that belong to specified categories rapidly and consistently. More sophisticated tools that can learn semantic, high-level, richer aspects are being offered to address the existing issues as deep learning advances. There are several types of algorithms. Based on the model training approach, the algorithms can be divided into two categories: single-stage detection algorithms and two-stage detection algorithms. Our investigation begins with an overview of deep learning and its most prominent tool, the Convolutional Neural Network (CNN). We'll also look at a common traditional object detection framework, along with some variations. Other tasks such as face detection and object tracking, as well as other important characteristics, would be implemented. Thus, future work in both object detection and relevant neural network-based learning systems should adhere to these guidelines and be useful. Important terms: SSD, Convolution Neural Network, YOLO
Smart Health Card Using Neural Networks
Authors: Dange Prajwal , Jagtap Sourav , Padole Pankaj , Saraswat Prof. S. S.
Published: June 2022

Abstract: The Infection Prediction Framework is built on predictive displaying. The framework examines the client's side effects as well as their present and clinical history. System also determines the severity of infection and recommends treatment based on severity of the condition. It recommends a healthy diet and appropriate physical activity for the client. Expecting infection at a later stage becomes a considerable task. The Convolutional neural Network (CNN) model is used to anticipate such anomalies, as it can precisely identify information related to infection expectation from unstructured clinical health records. However, assuming that CNN uses a completely coupled network structure, it consumes a lot of memory. In addition, an increase in the number of layers might lead to an increase in the model's intricacy examination. The prediction of infection at an early stage becomes a critical task. This prediction can help people understand their potential stage of disease and take action accordingly as soon as possible. Prediction cannot be 100% correct as it is a probability statistic and cannot be always right. However, it can possibly be helpful in very serious situations and can lives. Keywords: Infection Prediction, Health Card, CNN (Convolutional Neural Networks), Smart disease prediction
A Study on Awareness about Statutory Benefits among Casual Labours in a Multi-Speciality Hospital in Coimbatore
Authors: Latha Dr. R , Leenaa C.
Published: June 2022

Abstract: Statutory benefits are labour benefits which are implemented and required by the government. These statutory benefits include ESI, PF, maternity leave, wages and gratuity. It also enables them to choose the benefits based on their personal situation. When casual labours lack awareness about statutory benefits they can't use the benefits at right situation. The purpose of this study is to look into the awareness about statutory benefits among casual labours. Here a questionnaire was framed and circulated to the employees at the hospital. The expected outcome of this paper is to improve the already existing work place safety for casual labours in the hospital. The findings are also expected to pave the way for future research purpose. Keyword: Benefits, statutory, casual labours, employee, hospital, awareness.
Improving MGMP teachers’ self-efficacy through technical guidance in learning from home program
Authors: Suryawati Evi , Harfal Zaldi , Syafrinal S
Published: June 2022

The target of this technical guidance was secondary teachers of natural sciences, social sciences, and language who were members of the Teachers Professional Development Forum or Musyarawah Guru Mata Pelajaran (MGMP) in Siak Kecil, Bengkalis Regency. This training aimed to provide digital literacy strengthening for teachers in designing, implementing, and evaluating home-learning programs. This technical guidance was carried out through an online platform (Zoom) and offline mentoring in the MGMP discussion forum. The technical guidance mechanism consists of training and simulations in designing digital learning media in PowerPoint presentations, video monologues, e-student worksheets, and e-modules using software applications such as Filmora, Explee, Sigil, and Kinemaster. The results of this technical guidance were increasing self-efficacy with indicators of confidence in completing tasks (high), internal motivation (high), persistence (high), and being able to overcome obstacles and difficulties (high). There was also an increase in teachers' digital literacy in the aspects of data awareness (good), data analysis skills (sufficient), and ability to focus (excellent). The assessment of the results also showed that participants could design and use applications to carry out digital learning from home. Overall, this technical guidance positively impacted teachers' Continuing Professional Development (CPD), especially secondary teachers in Siak Kecil and Lubuk Dalam Sub-districts in Riau Province.
Improving knowledge, attitudes, and practices of COVID-19 reduction through Santri Husada Program
Authors: Ikhsan M Alifudin , Anam Faris Khoirul , Hanafi Yusuf , Adzim Abdul , Muzdalifah Zahrotul
Published: June 2022

Prefentive and currative efforts of COVID-19 in pesantren is a crucial points to be done in order to conduct conducive and safe learning situation. This community service aims to form, train and assist Santri Husada in carrying out its role in the health sector of Islamic boarding schools. This campus environmental service program offers many paradigm shifts for students by allowing them to participate in maintaining the health of pesantren residents who have previously appeared to disregard health protocols. It was carried out in three phases, namely education and outreach, training, and intensive mentoring from March to May 2021 at Darul Faqih Islamic Boarding School Malang. The survey results on students’ knowledge, attitudes and practices towards COVID-19 showed a good score with the correlation (R-square: P-Value) knowledge-attitude (0.167: 0.000), knowledge-practice (0.060: 0.000) and attitude-practice ( 0.051: 0.000). This community service program was carried out in collaboration with LP2M Universitas Negeri Malang, UPT Wagir Health Center, Polyclinic of Universitas Negeri Malang and the COVID-19 Task Force, Wagir District, Malang Regency. The Santri Husada Program has made a real contribution in suppressing the spread of COVID-19 in the Islamic boarding school environment and led it a tough Islamic boarding school area.
Training and health assistance for the elderly at the Griya Asih Home Care-Lawang, Malang
Authors: Wardojo Sri Sunaringsih Ika , Rosadi Rakhmad
Published: June 2022

The arrangement of systems and facilities of the home care according to the needs of the elderly is still one of the obstacles at the Griya Asih home care Lawang-Malang, so that the management of the home care needs assistance activities. This activity aimed to increase the active participation of the target community (caregivers at elderly home care) in overcoming health problems that arise in elderly home care. The implementation methods were: (1) Training and mentoring on the rehabilitation of the elderly and (2) Training programs and health assistance for the elderly. Service activities have been carried out well according to the target, which is indicated by an increase in knowledge of 75%. In addition, the management of the elderly home care also provides positive support which is indicated by their involvement in the implementation of activities.
Back Matter
Authors: Matter Back
Published: June 2022

Back Matter