bluuebunny/crossref_metadata_2025 huggingface dataset:
INVESTIGATION OF GENE EXPRESSION LEVELS OF SOME PROTEINS RELATED TO THE PATHOGENESIS OF PARKINSON'S DISEASE IN RATS EXPOSED TO PRENATAL STRESS
Authors: Varol İlayda , Turunç Ezgi
Published: June 2024

INVESTIGATION OF GENE EXPRESSION LEVELS OF SOME PROTEINS RELATED TO THE PATHOGENESIS OF PARKINSON’S DISEASE IN RATS EXPOSED TO PRENATAL STRESS
Ilayda VAROL1*, Sinem Ezgi TURUNC OZOGLU2
1 Department of Biochemistry, Faculty of Pharmacy, Izmir Katip Çelebi University, Izmir, Türkiye
2 Department of Biochemistry, Faculty of Pharmacy, Izmir Katip Çelebi University, Izmir, Türkiye
ORCID Numbers:
İlayda Varol: 0009-0000-4037-8612
Sinem Ezgi Turunc Ozoglu: 0000-0002-7587-7443
*Corresponding author:
Ilayda VAROL
Department of Biochemistry, Faculty of Pharmacy, Izmir Katip Çelebi University, Izmir, Türkiye
E-mail: varolilayda@gmail.com
Tel: +90 507 333 18 35
Ethical Committee Approval: The Ege University Ethics Committee on Animal Experiments approved this study (05/24/2017; Reference No. 2017-023).
INVESTIGATION OF GENE EXPRESSION LEVELS OF SOME PROTEINS RELATED TO THE PATHOGENESIS OF PARKINSON’S DISEASE IN RATS EXPOSED TO PRENATAL STRESS
Abstract
This study was carried out in order to better understand how prenatal stress (PS) may affect the future onset of Parkinson's disease (PD). A dexamethasone-induced PS model was established in rats for the study. Changes in the expression levels of tyrosine hydroxylase (TH), α-synuclein (SNCA), dopamine transporter (SLC6A3), and parkin (PRKN) proteins, which play role in PD pathogenesis, were demonstrated by real-time PCR in the cerebral cortex of male rats exposed to PS. From GD 14 to 21, pregnant rats were injected daily with Dex or saline (100 μg/kg and 1 ml/kg). 3 months after birth, male rats underwent decapitation (n=5), cerebral cortex dissection was performed. Total RNA was isolated from cortexes and used for cDNA synthesis. Gene expression analyzes were performed according to the ∆∆CT method. The statistical differences between groups were analyzed by the Mann-Whitney test. Statistics were deemed significant at a level of 0.05. Dex exposure throughout pregnancy significantly increased mRNA levels of TH and SLC6A3. No significant differences were found in the mRNA levels of PRKN and SNCA between experimental groups. In conclusion, offspring exposed to PS may be more susceptible to PD in adulthood through changes in the cortical mRNA levels of TH and SLC6A3.
Keywords: Prenatal stress, Parkinson’s Disease, Tyrosine hydroxylase, Dopamine transporter
Os olhos de Guadiana:
Authors: Oliveira Ana Coimbra , Roubaud Luísa , Santos Lara , Dovigo Maria Seoane , Scarth Susan
Published: June 2024

Como dar continuidade e como partilhar, através da escrita, uma experiência e um pensamento decorrentes da dança movimento terapia? Que escrita corporificada (embodied) é movimento em si? O que é uma escrita corporificada? O que seria uma escrita sem corpo? Na língua espanhola diz-se “ser como o Guadiana” para descrever algo que ocorre espaçada e irregularmente, ou quando alguém ou algo desaparece de repente e volta a aparecer sem aviso. Algo que desaparece, tal como o corpo parece que desaparece, do dia-a-dia, das palavras, do pensamento, da consciência, do diálogo, e volta a aparecer, por vezes de repente, em caso de doença, mas também no amor e no prazer, nos gestos de cuidado ou carinho, na dança. Este texto emerge de um trabalho de colaboração e coautoria que se pretende relevar. A sua intenção é dar espaço e voz diferenciados e nítidos aos diversos papéis e participações que edificam uma investigação em dança, em que pensar sobre e a partir do movimento do corpo se constitui como prática reflexiva de pesquisa, expressão, integração e comunicação. Manifestá-los, enfim, numa escrita propiciadora de futura reflexão científica.
The Impact of Islamophobia on the Education and Religious Identity of Muslims in the USA
Authors: Tuzer Salih
Published: June 2024

The experiences of Islamophobia among Muslims in Western countries, especially in the United States, escalated rapidly following the aftermath of 9/11. This study aims to investigate the Islamophobia experiences of American Muslims and its impact on their education and religious identity. By employing a systematic literature review, this research indicates that the challenges endured by Muslims not only complicated the reconciliation between their Muslim and American identities but also impeded the proper education of Muslim children. In the resurgence of Neo-racism, Muslims have experienced numerous adversities, ranging from hostile stares to the extent of being deported. Muslims have responded to this in various ways, such as hiding their Muslim identities or educating themselves and non-Muslims about Islam. Muslim women have been subjected to unfortunate incidents, including staying indoors, removing their headscarves, and facing negative perceptions in the mainstream American media. Muslim children have encountered difficulties in their education due to misconceptions about Islam both in the media and school curriculum. Although completely eradicating Islamophobia from the USA may be an unrealistic goal, it is feasible to mitigate its adverse impacts through decent education about Islam. This education could be achieved through elevating the voices of knowledgeable Muslims in the American media, increasing Islamic educational programs on TV, raising awareness among the American public, and integrating details about the origins of Muslims in the USA, the contributions of Muslims to science, the similarities of Islam with other major religions in the USA, and the diverse spectrum within Islam into school curriculums.
DEVELOPMENT OF PARAMETERIZED MODEL OF LOGIC ELEMENTS AT CLOCK TREE SYNTHESIS
Authors: MELIKYAN V.Sh. , GALSTYAN A.A. , GHUKASYAN S.A. , GHAZARYAN A.A. , KARAPETYAN E.E.
Published: June 2024

Clock synthesis, routing optimization, placement and logic optimization are the three primary phases of physical design implementation. Since clock network synthesis uses at least 30% of the entire power budget, it is one of the crucial steps. Power consumption for high-performance blocks can reach 50% of the entire power. Not only would a high-quality clock tree will fix timing violations, but it will also minimize power usage and routing resource use. A new neural network based parameterized model is proposed in this paper, which can be used to obtain not only the list of logic elements, but it also can predict the circuits timing behaviour. Different ICs using SAED 14 and 32 nm technologies are designed using the proposed method.
BENCHMARKING AND IMPLEMENTING DEEP LEARNING ALGORITHMS ON FIELD PROGRAMMABLE GATE ARRAYS AND APLLICATION SPECIFIC INTEGRAL CIRCUIT PLATFORMS
Authors: AVETISYAN A.A. , GRIGORYAN M.T. , MELIKYAN A.V.
Published: June 2024

Issues on the enhancement of Artificial Intelligence (AI) performance using Field-Programmable Gate Arrays (FPGA) and Application-Specific Integrated Circuits (ASIC) are studied. It focuses on benchmarking and implementing deep learning algorithms, crucial components of modern AI, on these advanced hardware platforms. The study begins with an explanation of the significance of deep learning in AI and the growing need for efficient computing platforms like FPGA and ASIC. These platforms are known for their high-speed processing capabilities and low power consumption, making them ideal for AI applications.
The research then delves into a detailed analysis of how deep learning algorithms can be optimized and executed on FPGA and ASIC platforms. It highlights the methods used to benchmark the performance of these algorithms on the mentioned hardware, providing a clear comparison with traditional computing systems. The paper also discusses the challenges and solutions in integrating deep learning algorithms into these specialized hardware environments.
Further, the advantages of using FPGA and ASIC for AI tasks, including improved processing speed, reduced energy consumption, and enhanced ability to handle complex AI computations are studied.
Uso de J-clic para mejorar las habilidades cognitivas en niños de educación inicial 2 en la Escuela de Educación Básica Consejo Provincial de Napo, Lago Agrio
Authors:   Instituto Superior Tecnológico Martha Bucaram de Roldós, Nueva Loja, Ecuador., Erique Ramírez Diego Paúl , Barba Vásquez Gloria Esperanza ,   Instituto Superior Tecnológico Martha Bucaram de Roldós, Nueva Loja, Ecuador., Chamba Saida Cecilia ,   Instituto Superior Tecnológico Martha Bucaram de Roldós, Nueva Loja, Ecuador.
Published: June 2024

La educación de calidad es clave a nivel global, aunque en Ecuador, especialmente en zonas desfavorecidas como Lago Agrio, hay desafíos en la práctica. En respuesta a estos desafíos, se desarrolló un proyecto de investigación centrado en el software educativo J-Clic con el objetivo de mejorar las habilidades cognitivas de los estudiantes. La metodología utilizada fue un diseño cuasi experimental, que incluyó tanto un grupo control como un grupo experimental. Los resultados obtenidos revelaron mejoras significativas en el grupo experimental en comparación con el grupo control en todas las dimensiones evaluadas. Específicamente, los niños que utilizaron J-Clic mostraron un mayor desarrollo en la identificación, análisis y resumen de elementos, lo que respalda la eficacia del software para mejorar la capacidad cognitiva de los estudiantes de inicial 2. En conclusión, la implementación exitosa de J-Clic como herramienta educativa demostró un impacto positivo en el desarrollo cognitivo de los estudiantes.
A Comparison of Measures for Assessing Profile Similarity in Dyads
Authors: Carlier Chiara , Karch Julian D. , Kuppens Peter , Ceulemans Eva
Published: June 2024

Profile similarity measures are used to quantify the similarity of two sets of ratings on multiple variables. Yet, it remains unclear how different measures are distinct or overlap and what type of information they precisely convey, making it unclear what measures are best applied under varying circumstances. With this study, we aim to provide clarity with respect to how existing measures interrelate and provide recommendations for their use by comparing a wide range of profile similarity measures. We have taken four steps. First, we reviewed 88 similarity measures by applying them to multiple cross-sectional and intensive longitudinal data sets on emotional experience and retained 43 useful profile similarity measures after eliminating duplicates, complements, or measures that were unsuitable for the intended purpose. Second, we have clustered these 43 measures into similarly behaving groups, and found three general clusters: one cluster with difference measures, one cluster with product measures that could be split into four more nuanced groups and one miscellaneous cluster that could be split into two more nuanced groups. Third, we have interpreted what unifies these groups and their subgroups and what information they convey based on theory and formulas. Last, based on our findings, we discuss recommendations with respect to the choice of measure, propose to avoid using the Pearson correlation, and suggest to center profile items when stereotypical patterns threaten to confound the computation of similarity.
LUDWİG LACHMANN VE AVUSTURYA İKTİSAT OKULU’NDAN KURUMSAL İKTİSADA AÇILAN EYLEM TEORİSİ
Authors: Levent Adem
Published: June 2024

2000’li yıllardan sonra Ortodoks neoklasizmin sınırlı rasyonalite, kural takibi, kurumlar, bilişsellik ve evrim gibi ilkeleri benimseyerek değiştiği ve yeni yaklaşımlara doğru açıldığı ileri sürülmüştür. Bu yeni yaklaşımlardan birinin de Avusturya iktisat okulu olduğu düşünülmektedir. Ancak 1970 sonrası Avusturya iktisat okulunun canlanışında büyük bir paya sahip olan Ludwig Lachmann’ın düşünceleri Ortodoks neoklasizmle uyumlu değildir. Lachmann’ın sürekli değişen dünya, akan zaman, farklılaşan beklentiler ve planlara dayanan insan eylemi düşünceleri neoklasizm başta olmak üzere Ortodoksinin hiçbir türüne uyum sağlayamaz. Bundan dolayı Lachmann’ın düşünceleri özelinde Avusturya iktisat okulunun Ortodoks neoklasizmle birlikte iktisat biliminin merkezine yerleşmesi mümkün değildir. Çalışma, Lachmann’ın Avusturya iktisat okulu içindeki söz konusu özel konumunu tartışmayı ve Ortodoks neoklasizmle uyuşması mümkün olmayan plan temelli insan eylemleri ile radikal öznelciliğe yaslanan yorumlayıcı kurumsal iktisat düşüncesi taşıdığını savunmaktadır. Çalışmanın temel iddiası, Lachmann’ın plan temelli eylem teorisi ile sadece Max Weber üzerinden Kıta Avrupa yorumlayıcı sosyolojisi iktisada taşınmamış, aynı zamanda Avusturya iktisat okuluyla kurumsal iktisat da yakınlaşmıştır.
Was denkst du, wer du bist
Authors: Frenkel Ulrike , Munro Alice
Published: June 2024

Alice Munro, Das Bettlermädchen. Geschichten von Flo und Rose. Aus dem Englischen von Hildegard Petry. S. Fischer, Frankfurt a. M. 2014. 336 Seiten, 19,99 Euro
Fliehender Holländer am Klavier
Authors: Freitag Christel , Canal Anne von
Published: June 2024

Anne von Canal, Der Grund. Roman. Mare Verlag, Hamburg 2014. 272 Seiten, 20 Euro
Mitja, mein Mitja
Authors: Granzin Katharina , Vuorela Seita
Published: June 2024

Seita Vuorela, Wir fallen nicht. Roman. Aus dem Finnischen von Tanja Küddelsmann. Ravensburger Buchverlag, Ravensburg 2014. 352 Seiten, 16,99 Euro
Im Strudel der Revolutionswirren
Authors: Saalfeld Lerke von , Harėcki Maksim Ivanavič
Published: June 2024

Maxim Harezki, Zwei Seelen. Roman. Aus dem Weißrussischen von Norbert Randow und Gundula und Wladimir Tschepego. Guggolz Verlag, Berlin 2014. 224 Seiten, 20 Euro
Studienort Freiburg
Authors: Tabbert Reinbert , Atze Marcel
Published: June 2024

Marcel Atze, Sebald in Freiburg. Spuren 102. Deutsche Schillergesellschaft, Marbach a. N. 2014. 16 Seiten, 13 Abbildungen, 4,50 Euro
Märchenforschung
Authors: Boden Petra , Scheer Regina
Published: June 2024

Regina Scheer, Machandel. Knaus, München 2014. 480 Seiten, 22,99 Euro
Polen im Herzen
Authors: Hübner Klaus , Becker Artur
Published: June 2024

Artur Becker, Sieben Tage mit Lidia. Novelle. weissbooks.w, Frankfurt a. M. 2014. 196 Seiten, 17,90 Euro
Liebe im Alter
Authors: Braun Astrid , Knauss Sibylle
Published: June 2024

Sibylle Knauss, Das Liebesgedächtnis. Klöpfer & Meyer, Tübingen 2015. 192 Seiten, 20 Euro
Subversiver Witz
Authors: Frenkel Ulrike , Von Arnim Elizabeth
Published: June 2024

Elizabeth von Arnim, Elizabeth und ihr deutscher Garten. Aus  dem Englischen von Hans- Ulrich Möhring und Karen Nölle. edition fünf, Gräfelfing/Hamburg 2014. 151 Seiten, 18,90 Euro
Wider Verfall und Vergessen
Authors: Birkert Alexandra , Pfäfflin Friedrich , Pfäfflin Waltraud
Published: June 2024

Waltraud und Friedrich Pfäfflin, Die Gräber der Dichter auf dem Stuttgarter Hoppenlau-Friedhof. Mit einem Essay von Udo Dickenberger. Edition Vincent Klink, Stuttgart 2015. 420 Seiten mit 68 Abb. und Übersichtsplan, 24 Euro
Historisches Wetterleuchten
Authors: Weingartner Gabriele , Kopetzky Steffen
Published: June 2024

Steffen Kopetzky, Risiko. Roman. Klett-Cotta Verlag, Stuttgart 2015. 731 Seiten, 24,95 Euro
Keiner stirbt
Authors: Tröger Beate , Kurzeck Peter
Published: June 2024

Peter Kurzeck, Bis er kommt. Romanfragment (Das alte Jahrhundert 6). Aus dem Nachlass herausgegeben von Rudi Deuble und Alexander Losse. Stroemfeld / Roter Stern, Frankfurt a. M. 2015. 374 Seiten, 24,80 Euro
Mechanik hinter Schaukämpfen
Authors: Mylo Ingrid , Salinger Jerome D.
Published: June 2024

Jerome D. Salinger, Die jungen Leute. Drei Stories. Aus dem Amerikanischen von Eike Schönfeld. Piper, München 2015. 67 Seiten, 14,99 Euro (leider schon vergriffen)
СҮТ БЕЛОГЫ ПЕПТИДТЕРІНІҢ АНТИМИКРОБТЫҚ БЕЛСЕНДІЛІГІ
Authors: NARMURATOVA M.Kh. , USMANOVA Z.U. , GHAFOORI E.M. , АSKAR А.Zh. , ZHUNISBEK А.М. , NARMURATOVA Zh B.
Published: June 2024

This article describes the antimicrobial activity of milk proteins and peptides formed from them. Today, the global problem of modern medicine and the entire humanity is the resistance of pathogenic microorganisms to antibiotics. Widespread and uncontrolled use of antimicrobial drugs, as well as non-compliance with treatment regimens, contributes to the proliferation of this phenomenon. The emergence of antibiotic-resistant types of pathogenic microorganisms, which contribute to the development of incurable and fatal diseases, is especially dangerous. In this regard, the search and development of new groups of drugs that can affect the activity and development of pathogenic microorganisms is relevant. Antimicrobial peptides are one of the potential groups of compounds with the desired set of effects against pathogenic microorganisms. Antimicrobial peptides are a family of small peptides that occur in nature and play an important role in the body's innate immune system. In addition, antimicrobial peptides can be produced from various protein sources such as milk by enzymatic hydrolysis or fermentation with microorganisms. Antimicrobial peptides are widely used in the food and pharmaceutical industries.

Бұл мақалада, сүт белоктары және олардан түзілелін пептидтердің антимикробтық белсенділігі туралы сипатталған. Қазіргі уақытта заманауи медицинаның және бүкіл адамзаттың жаһандық мәселесі патогенді микроорганизмдер антибиотиктерге төзімділігі болып табылады. Бұл құбылыстың кең таралуына патогенді микроорганизмдерге қарсы препараттарды кеңінен және бақылаусыз қолдану, емдеу режимдерін бұзу ықпал етеді. Әсіресе, емделмейтін және өлімге әкелетін аурулардың дамуына ықпал ететін патогенді микроорганизмдердің антибиотиктерге төзімді түрлерінің пайда болуы қауіпті. Осыған байланысты патогенді микроорганизмдердің тіршілік әрекеті мен дамуына әсер ете алатын дәрілік заттардың жаңа топтарын іздеу және дамыту өзекті болып табылады. Патогенді микроорганизмдерге қарсы әсерлердің қажетті жиынтығы бар қосылыстардың потенциалды топтарының бірі микробқа қарсы пептидтер (антимикробтық пептидтер). Негізінен, антимикробтық пептидтер - бұл табиғатта кездесетін және организмнің туа пайда болған иммундық жүйесінде маңызды рөл атқарады. Бұдан басқа, антимикробтық пептидтер сүт сияқты әртүрлі белок көздерінен ферменттік гидролиз немесе микроорганизмдер көмегімен ашыту арқылы өндірілуі мүмкін. Антимикробтық пептидтер тағам және фармацевтика өнеркәсібінде кеңінен қолданылады.
La redacción científica en inglés como lengua extranjera
Authors: Sánchez Alvarado Alber Francisco
Published: June 2024

Este trabajo de investigación explora la compleja interacción entre la memoria de trabajo (MT) y el dominio de la escritura en inglés como lengua extranjera, particularmente para los hablantes de inglés de L2 de español.  Postula que estos individuos se enfrentan a desafíos cognitivos en la MT debido a la complejidad inherente de la escritura en lenguas extranjeras (L2). El documento aboga por la adopción de un enfoque de aprendizaje profundo durante las primeras etapas de la adquisición del inglés para hacer frente a estos desafíos de manera efectiva. Haciendo hincapié en la importancia de adquirir de manera óptima las habilidades fundamentales, como escuchar, hablar y leer, recomienda que los escritores de L2 cultiven concienzudamente estas habilidades para mejorar sus habilidades de escritura. Este compromiso proactivo con las habilidades fundamentales, junto con las estrategias para tomar notas a mano, se propone como un medio estratégico para que los escritores de L2 superen las demandas cognitivas asociadas con el dominio de la escritura en inglés.
Aplicaciones de las derivadas parciales en las ciencias económicas: función de costo y producción
Authors: López Sánchez Norman Rafael , Herrera Castrillo Cliffor Jerry
Published: June 2024

El presente artículo de investigación tiene como título “Aplicaciones de las derivadas parciales en las ciencias económicas: Función de costo y producción”, el cual consiste en una serie de situaciones con sus respectivas soluciones aplicables en el área de las ciencias económicas y empresariales. El objetivo de este estudio es disponer de una guía de problemas con sus respectivas soluciones mediante derivadas parciales aplicadas en el área de Administración y Economía. Se utilizó un análisis descriptivo y un enfoque mixto con predominancia cualitativa, proporcionando una mejor adquisición de las ciencias exactas puesto que se tomaron aspectos relevantes de diferentes fuentes de información confiables. Por medio de este estudio se logró obtener resultados de calidad que ayuden a fomentar e incrementar los conocimientos tanto de estudiantes como también docentes que puedan acceder a este estudio y esto contribuye al desarrollo del aprendizaje significativo en materia de ciencias económicas y administrativas, puesto que toma los aspectos de innovación en la resolución de problemas y además permite fortalecer el pensamiento crítico.
Diseño de curso de español como lengua extranjera según necesidades de aprendizaje
Authors: Murillo Reyes Henry Alexander , Morales Soza Madia Gisselle , González Solís Jader Wilder , Miranda Téllez Marta Elizabeth
Published: June 2024

Hacer referencia a la enseñanza de español, a extranjero, con fines específicos es una disciplina relativamente nueva y tiene unas características que la diferencian de la enseñanza de español en general. En este sentido, este tipo de enseñanza está cobrando cada vez más importancia por motivos socioeconómica y sociales porque cada vez hay más personas interesadas en aprender un idioma enfocado a un fin específico, como el caso que se trata en esta sistematización en el que se les brindó atención a estudiantes con fines específicos. De ahí que este trabajo tiene como objetivo principal describir el proceso de aprendizaje e investigación sobre las necesidades del aprendizaje del grupo meta a aprender español quienes en su conjunto tenían necesidades claramente definidas y centradas económicas y sociales por tratarse de un grupo que se dedican a construcción de obras horizontales. La investigación se realizó mediante un enfoque cualitativo. Esta metodología permitió aplicar instrumentos y técnicas con las que logró incidir de manera significativa y directa con el grupo meta (aprendientes). Para la recogida de la información se construyó cuestionario para entrevista a profundidad y de esa manera lograr la caracterización del grupo meta. Para procesar la información obtenida, se dividió las acciones en tres fases fundamentales, también se hizo uso de análisis interpretativo y caracterización de elementos y para ello se elaboró una matriz de doble entrada, así como análisis de los discursos. Los métodos teóricos y empíricos permitieron realizar un análisis integral (radiografía) del grupo meta. También se aplicó la técnica de triangulación de información y se tomó en cuenta la relación entre los objetivos del grupo y los contenidos a desarrollarse. Los resultados de esta investigación llevaron a plantear una nueva línea de investigación: una propuesta o diseño de curso con fines específicos atendiendo, especialmente el personal de la institución demandante.
Carbon Dioxide and Nitrate Electrocatalytic C-N Coupling for Sustainable Production of Urea
Authors: Jia Litao , Li Fanghua
Published: June 2024

Review
Carbon Dioxide and Nitrate Electrocatalytic C-N Coupling for Sustainable Production of Urea

Litao Jia, and Fanghua Li *

School of Environment, Harbin Institute of Technology, Harbin 150090, China
* Correspondence: fanghuahope01@hit.edu.cn
Received: 15 December 2023; Revised: 17 January 2024; Accepted: 19 February 2024; Published: 5 March 2024
 

Abstract:
The electrocatalytic co-reduction of carbon dioxide (CO2) and nitrate (NO3−) for urea synthesis under environmental conditions offers a promising solution for achieving sustainable environmental management. Besides, electrochemical urea synthesis is an alternative approach for cleaner production of urea compared to the conventional urea industrial production process with high energy consumption and pollution. However, lower urea yield, lower selectivity and unclear C-N coupling reaction mechanism are still the main challenges to its large-scale application. In this review, we focus on accurate and reliable detection methods and evaluation criteria for urea products, recent progress on CO2 and NO3− electrocatalytic co-reduction synthesis of urea, rational design of high-performance electrocatalysts, and C-N coupling reaction mechanism of urea electrochemical synthesis under atmospheric conditions. This review could contribute to the development of electrochemical urea synthesis via effective remediation of CO2 and NO3−.
Porous Graphitic Carbon Nitride-Based Photocatalysts for Antibiotic Degradation
Authors: Wang Zhaoqiang , Ding Guixiang , Zhang Juntao , Wang Peng , Lv Qi , Ni Yonghao , Liao Guangfu
Published: June 2024

Review
Porous Graphitic Carbon Nitride-Based Photocatalysts for Antibiotic Degradation

Zhaoqiang Wang 1, Guixiang Ding 1, Juntao Zhang 1, Peng Wang 2, Qi Lv 3, Yonghao Ni 4 and Guangfu Liao 1,*

1 National Forestry and Grassland Administration Key Laboratory of Plant Fiber Functional Materials, College of Materials Engineering, Fujian Agriculture and Forestry University, Fuzhou 350002, China
2 Shandong Chambroad Petrochemicals Co., Ltd., Binzhou 256500, China
3 PCFM Lab, GD HPPC Lab, School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510275, China
4 Department of Chemical Engineering, University of New Brunswick, Fredericton, NB E3B 5A3, Canada
* Correspondence: liaogf@mail2.sysu.edu.cn
Received: 29 November 2023; Revised: 18 January 2024; Accepted: 24 January 2024; Published: 5 March 2024
 

Abstract: Photocatalytic technology is a promising strategy for solving antibiotic pollution present in the water system. Porous carbon nitride (PCN) material has been considered as a potential candidate to solve the above problem due to the abundant reaction sites, large specific surface area and narrow band gap. Recently, substantial research focus on promoting photocatalytic activity of PCN-based material via improving photogenerated carrier separation and band gap structure has been completed. However, only a few works summarize and discuss the results of research on photocatalytic antibiotic degradation by PCN-based photocatalysts in recent years. Thus, a review on recent developments in PCN-based photocatalysts research is urgently needed to further promote its advancement. In this review, the synthesis strategies, structure design and photocatalytic application of antibiotic degradation over PCN-based photocatalysts are listed in detail. Finally, a brief conclusion has been discussed deeply, which focuses on the future challenges and expectations of PCN-based photocatalysts for photocatalytic antibiotic degradation. This review offers a novel viewpoint on the use of PCN-based material in photocatalytic antibiotic degradation and highlights its significant potential as a photocatalyst. In short, the application of PCN-based materials in the photocatalytic degradation of antibiotics is very promising, according to objective assessments.
Cellulosimicrobium spp., potencial antimicrobiano em testes de sensibilidade e microdiluição
Authors: Borges Ana Lúcia de Oliveira , Bento Cintia dos Santos , Souza Tércio da Silva de , Moulin Monique Moreira , Menini Luciano , Silva Fernanda Pereira da , Souza Gustavo Rodrigues de , Venancio Aldino Neto , Marcos Rodrigues Agostinho
Published: June 2024

O objetivo deste trabalho foi apresentar a rizobactéria Cellulosimicrobium spp., de características visuais semelhantes a individuo de importância agronômica, causador da doença mancha bacteriana, com dados alcançados em testes de disco difusão, avaliação qualitativa, com  uso de discos de papel de 6 mm, com tratamentos de óleo essencial de cravo botão e laranja doce, majoritários eugenol e d-limoleno, com as medidas de  0.008, 0.010, 0.015, 0.020 e 0.025 g/L  e com as medidas de 0.015 g/L para os controles: antibiótico (cefalexina) e produto químico (Hidróxido de cobre) e delineamento inteiramente casualizado, em arranjo fatorial (5 x 3 x 3 ou 5 x 3) com três repetições.  Para teste quantitativo, ocorreu a contagem de células viáveis após aplicação de emulsões de óleo essencial de cravo botão (0,157 g/L) e majoritário eugenol (0,028 g/L), nos percentuais de 100 a 3,12%. O microorganismo Cellulosimicrobium spp., foi repicado em meio sólido e liquido digs, cultivado a 32 º C, sob as densidades opticas 0,2 a 0,4 DO a 600 nm. Na avaliação qualitativa, apenas cravo, laranja doce e o majoritário eugenol, mantiveram 5 (cinco) medidas de halo em mm, o tratamento farmacêutico, chegou a 24 mm (0,015 g/L), laranja doce a partir de 0,015 g/L, formou halos de 19,5 mm a 38,5 mm, com a máxima concentração de 0,025 g/L, enquadrando-se na classificação de sensibilidade, com halo > 18 mm. Nos testes de microdiluição, avaliação quantitativa, em meio líquido, não revelou resultado de inibição para os tratamentos de laranja doce, majoritário d-limoleno e cefalexina, em todas repetições houve normal crescimento do indivíduo e para hidróxido de cobre houve total inibição para Cellulosimicrobium spp.,. Nos testes de contagem de células viáveis, foi observado nos tratamentos de cravo botão e eugenol, células sobreviventes nos percentuais 50 a 3,12%, com a contagem de células, a partir da diluição reproduzida em meio sólido, contabilizada pelo aplicativo Image-J, com registro de coeficiente de variação de 82,5% para cravo botão e 50,5% para os números de eugenol.
Educação 5.0 no ensino de engenharia: uma revisão da literatura
Authors: Cordeiro Priscila Mattos , Gomes Felipe Luiz Machado , Luz Raquel Sant’Ana da , Bersot Igor Farah , Campos Isadora Alves , Santos Hyago Dorneles dos , Amaral Mateus Carvalho , Sobral Ana Paula Barbosa
Published: June 2024

A aplicação do conceito de Educação 5.0 no ensino de Engenharia pode trazer inúmeras vantagens e transformações significativas na forma como os alunos são preparados para a indústria e para os desafios da profissão. No contexto da Educação 5.0, o ensino de Engenharia deve buscar uma abordagem mais personalizada e centrada no aluno, levando em consideração suas necessidades, interesses e habilidades individuais. Isso pode ser alcançado através de métodos de ensino mais interativos e participativos, que incentivam a colaboração, o pensamento crítico e a solução de problemas reais. Além disso, a Educação 5.0 enfatiza a importância do desenvolvimento de habilidades socioemocionais e do pensamento criativo. Dessa forma, os alunos são preparados para enfrentar as mudanças constantes da indústria e para se adaptar às novas tecnologias e demandas do mercado. Com a evolução do mercado de engenharia em resposta à transformação digital, os profissionais desse campo precisam adquirir habilidades diversas para colaborar com seres humanos e máquinas na era da indústria 5.0. Portanto, a educação em engenharia desempenha um papel fundamental na progressão da sociedade 5.0, exigindo abordagens inovadoras para o ensino da engenharia. Assim, este estudo tem como objetivo elencar os principais artigos sobre o tema educação 5.0 no ensino da engenharia por meio da bibliometria através das bases de dados Scopus e Web of Science. A pesquisa resultou em 60 publicações, que, após a análise, foram reduzidas para quatro de alta relevância. A partir desses resultados, foram selecionados os artigos para leitura, e posteriormente uma lista com apenas os artigos selecionados para análise. Por fim, foi apresentada uma análise dos quatro estudos mais relevantes que propõem mudanças significativas para o ensino de engenharia na era da indústria 5.0.
Pengaruh Budaya Organisasi Dan Kompetensi Konsep Spencer And Spencer Terhadap Kinerja Karyawan (Studi Kasus Karyawan Pegadaian Syariah Wilayah Yogyakarta)
Authors: Anshori Agnes Oktavia , Diwanti Dyah Pikanthi
Published: June 2024

Tujuan dalam penelitian ini untuk mengetahui pengaruh budaya organisasi (X1), dan pengaruh kompetensi dengan konsep Spencer & Spencer dengan variabel motives (X2), traits (X3), self concept (X4), knowledge (X5), dan skills (X6) terhadap kinerja karyawan. jenis penelitian ini adalah penelitian kuantitatif dengan menggunakan data primer berupa kuesioner. Sampel yang digunakan dalam penelitian  ini adalah seluruh karyawan Pegadaian syariah Wilayah Yogyakarta yang berjumlah 47 responden.
     Teknis analisis data yang digunakan dalam penelitian ini adalah Analisis Regresi Linier Berganda yang dioperasikan menggunakan software SPSS. Berdasarkan hasil uji F Probabilitas signifikasi 0,000 < 0,05 Ho ditolak dan Ha diterima, sehingga pada penelitian ini Budaya Organisasi, Motives, Traits, Self Concept, Knowledge, dan skills secara simultan berpengaruh signifikan terhadap Kinerja Karyawan Pegadaian Syariah Wilayah Yogyakarta. Dan skor koefisien determinasi R2 = 60% kinerja karyawan dapat dijelaskan oleh variabel Budaya Organisasi, Motives, Traits, Self Concept, Knowledge, dan skills dan sisanya 40 % dipengarungi oleh variabel bebas lainnya. Variabel Knowledge memiliki pengaruh paling besar dalam meningkatkan kinerja karyawan dibandingkan dengan variabel lainnya.
 Kata kunci: Budaya Organisasi, Motives, Traits, Self Concept, Knowledge, dan Skills, Kinerja Karyawan, Pegadaian Syariah.
Pengaruh Harga dan Iklan Terhadap Keputusan Pembelian Pada Marketplace Shopee
Authors: Sarjita Sarjita
Published: June 2024

This study aims to determine the effect of price and advertising together or partially on purchasing decisions in the Shopee marketplace. The research method used in this study is a quantitative research method using a sample of 70 respondents. The data analysis method used in this research is multiple linear regression. Based on the results of the t-test, it can be seen that the advertising variable has a significant effect on purchasing decisions, while price does not significantly affect purchasing decisions. Based on the beta test, the most dominant variable influencing purchasing decisions is the advertising variable. The value of the correlation coefficient (R) in this study is 0.795, meaning that the correlation test shows a strong and positive relationship, that is, if the independent variables (advertising and price) increase, the dependent variable (purchase decisions) will also increase. The value (R2) in this study was 0.632. This shows that 63.2% of purchasing decisions are influenced by price variables (X1) and advertising (X2). While the remaining 36.8% is influenced by other variables not examined in this study.
 
Keywords: Product, Price, Place, Promotion and Sales
Pengaruh Fasilitas, Ragam Layanan dan Kepuasan Pelanggan terhadap Loyalitas Pelanggan Miniâ€™s Salon Yogyakarta
Authors: Sulistyorini Ernita , Pramudyo Anung
Published: June 2024

Penelitian ini bertujuan untuk mengetahui pengaruh dari fasilitas, ragam layanan, dan kepuasan pelanggan baik secara parsial maupun simultan terhadap loyalitas pelanggan. Penelitian ini dilaksanakan pada Miniâ€™s Salon yang beralamat di Jalan Pundung No. 96, Gumuk, Godean, Sleman, Yogyakarta. Penelitian ini merupakan penelitian dengan menggunakan metode penelitian kuantitatif. Populasi dalam penelitian ini adalah seluruh pelanggan pada Miniâ€™s Salon Yogyakarta. Sampel diambil sebanyak 80 pelanggan dengan metode Nonprobability Sampling dengan menggunakan teknik Purposive Sampling. Data dalam penelitian ini dikumpulkan melalui observasi langsung ke lokasi penelitian dan dengan mengunakan kuesioner yang disebarkan kepada pelanggan Miniâ€™s Salon. Data selanjutnya dianalisis dengan menggunakan analisis deskriptif, uji kualitas instrument (uji validitas dan reliabilitas), uji asumsi klasik (uji normalitas, uji multikolinieritas, dan uji heteroskedastisitas), serta uji hipotesis melalui regresi linier berganda (uji t, uji F, uji R, dan uji R2) dengan menggunakan bantuan software SPSS 22.
Hasil dari penelitian ini menunjukkan bahwa variabel fasilitas, ragam layanan, dan kepuasan pelanggan secara parsial berpengaruh signifikan terhadap loyalitas pelanggan. Hal ini terlihat dari signifikansi uji t untuk masing-masing variabel fasilitas, ragam layanan, dan kepuasan pelanggan sebesar 0,005, 0,022, dan 0,006 lebih kecil daripada 0,05. Hasil uji F menunjukkan bahwa secara simultan fasilitas, ragam layanan, dan kepuasan pelanggan berpengaruh signifikan terhadap loyalitas pelanggan yang terlihat dari signifikansi uji F sebesar 0,000, dimana signifikansi ini lebih kecil daripada 0,05. Besarnya pengaruh dari fasilitas, ragam layanan, dan kepuasan pelanggan terhadap loyalitas pelanggan adalah sebesar 62,5%, sedangkan sisanya sebesar 37,5% dipengaruhi oleh faktor lainnya.
Kata Kunci : Fasilitas, Ragam Layanan, Kepuasan Pelanggan, Loyalitas Pelanggan
Pengaruh Kualitas Pelayanan terhadap Kepuasan Pasien Rawat Inap di RSUD Panembahan Senopati Bantul
Authors: Fathoni Muhammad Isnaini , Herlambang Susatyo
Published: June 2024

This study aims to determine the effect of service quality on inpatient satisfaction at Panembahan Senopati Hospital, Bantul. The population is people, while the sample used is 83 inpatients who perform inpatient services. The sampling technique in this study was accidental sampling, data collection was carried out by taking a questionnaire with a Likert scale. The analytical method used in this study was simple regression analysis with the SPSS 22 application. The results of the study (t test) showed that service quality had a significant effect on patient satisfaction with a significant value of 0.000 <0.05. The test results for the coefficient of determination obtained R Square of 0.302. this shows that the dependent variable of customer satisfaction is 30.2% influenced by the independent variable service quality, while 69.8% is influenced by other variables that have not been examined in this study.
PENGARUH SIKAP KONSUMEN DAN NORMA SUBYEKTIF TERHADAP KEPUTUSAN MENGGUNAKAN JASA KERETA API DI YOGYAKARTA
Authors: Endang Palupi Nunuk Dwi Garwanti
Published: June 2024

Tujuan penelitian ini adalah untuk mengetahui pengaruh Sikap Konsumen dan Norma Subyektif terhadap keputusan menggunakan jasa Kereta Api di Yogyakarta. Sampel dalam penelitian ini adalah konsumen yang menggunakan Jasa Kereta Api di Yogyakarta. Penelitian ini menggunakan metode purposive sampling, yaitu pengambilan sampel berdasarkan kriteria tertentu. Berdasarkan hasil penelitian diketahui Sikap Konsumen dan Norma Subyektif berpengaruh signifikan terhadap keputusan menggunakan jasa Kereta Api di Yogyakarta.
Protective Role of Doxofylline against Cyclophosphamide-induced Testicular Toxicity in Rats
Authors: Hussein Shaimaa Alii , Gatea Fouad Kadhim
Published: June 2024

Background: Cyclophosphamide (CP) is a widely used anticancer and immunosuppressant drug. However, CP's significant toxicities and adverse effects restrict its clinical use. Doxofylline (DF) is a phosphodiesterase inhibitor that has antioxidant and anti-inflammatory properties. Objective: To determine the protective effect of doxofylline on rats exposed to a single dose of CP. Methods: We randomly assigned thirty Sprague-Dawley male rats to three groups. On the sixth day, the apparently healthy control group (AH) received normal saline; the induction group (IN) received normal saline and a single dose of CP (100 mg/kg); and the DF group received DF (50 mg/kg) and a single dose of CP (100 mg/kg). Treatment in all groups was given once daily and intraperitoneally. At the end of treatment, caudal fluid is used to determine sperm parameters. A blood sample was taken to determine the testosterone levels. We determined the levels of testicular glutathione peroxidase and malondialdehyde. The testes were harvested, allowing for histological examination. Results: Sperm parameters, testosterone and oxidative stress markers were notably declining in testicular tissue among the IN compared with AH, although these measures can be markedly improved with DF. Histopathological analysis revealed a substantial change in the testicular tissue structure in the CP group, although doxofylline co-treatment significantly attenuated and even reversed these changes. Conclusions: Doxofylline may function as a protective agent, mitigating the testicular damage caused by CP therapy in rats. The proposed process may be attributed to its phosphodiesterase inhibitory and antioxidant properties.
Spatial Convolution Splines for Multivariate Spatial Data
Authors:   Department of Statistics - College of Administration and Economics -University of Karbala-Iraq, Sackineh Sackineh
Published: June 2024

The Spatial Convolution Splines Multivariate Regression Model (SCSMRM) were used on the data represented a diabetes disease measurements across different regions in Iraq (Basrah, Baghdad, Babylon, Sulaimanya) while considering multiple risk factors such as age, BMI, weight , income, education level, blood pressure for the same geographic location for (200) patient, and combine the health data with the risk factor data to create a comprehensive dataset. Each record in the dataset should include the geographic location, diabetes status, and values for each risk factor we applied (SCSMRM), the results showed that significant the model and the risk factors studied in the model explain 61% of the changes that occur in the diabetes. It also showed the significance of the factors (age - weight - body mass index (BMI) - educational level - blood pressure) and the non-significance of the variable (income), and these results are consistent with the actual reality of the disease.
Incorporating Kernels into Convolutional Neural Networks for Enhanced Feature Extraction
Authors:   Department of Statistics - College of Administration and Economics -University of Karbala-Iraq, Sackineh Sackineh
Published: June 2024

The simulation was used to evaluate the method of kernel K , Neural network NN, Convolution Neural network CNN bys using (MINIST) data set. The accuracy of the method was tested and compared with the convolutional neural network as well as with the kernel function for the same input data (training and testing). The results of simulation showed that there is a high accuracy of the method, and at the same time there is a decreasing loss over the epochs, which indicates the. We note high smooth by method for recognize among features.
Evoking Emotions and Eliciting Heart-Felt Responses Through Exclamatives: Unravelling the Potential of aiyyoo in the English Language
Authors: George Ruby , Sahoo Anindita
Published: June 2024

The English language is replete with exclamative utterances which convey an array of emotions and evoke strong sentiments that create a lasting impact in the hearts and minds of the users and listeners alike. However, they are not considered as conforming to the regular speech acts of the English language. The entry of aiyyoo, an expression of South Indian origin into the Oxford English Dictionary (OED), propels us to re-visit the Standard and Modified theories of speech acts and to look with fresh eyes at the striking features and contrasting perspectives on exclamatives. This paper dwells on the versatile dimensions of aiyyoo and gathers insights about its unique illocutionary force through the analysis of (1) religious texts, (2) a passage of Indian Writing in English (IWE), (3) some columns in leading English dailies and (4) typical oral Tamil discourses. The various modes of analysis serve to affirm the immense semantic potential of the exclamative. Pragmatically and stylistically, it plays a vital role in our speech acts as it helps to articulate our deepest thoughts and heartfelt emotions. Given the persuasive quality of the exclamative in speech and writing, the usage of aiyyoo should be encouraged to enhance interpersonal communication in the global community.
Sistemas CRISPR-CAS: una perspectiva histórica y estructural
Authors:   Endocrine and Metabolic Diseases Research Center. School of Medicine. University of Zulia. Maracaibo, Venezuela, Navarro Carla
Published: June 2024

Hace 40 años comenzó el viaje de la edición genética a través de las zinc-finger nucleases (ZFN) y las nucleasas de tipo activador de la transcripción (TALENs). El camino parecía largo y lleno de obstáculos debido a los potenciales efectos secundarios y limitaciones de dichas técnicas. No obstante, en el año 2002, después de años de interrogantes en la comunidad científica con respecto a la existencia de secuencias genéticas repetidas en distintos microorganismos, se nombra a dichas secuencias como clustered regularly interspaced short palindromic repeats (CRISPR). Desde ese momento, no se ha detenido la investigación determinando sus funciones, clasificación y potenciales usos en la edición de material genético de cualquier organismo, proveyendo ventajas con respecto a las técnicas utilizadas con anterioridad. En años recientes, su aporte a la medicina ha ganado cada vez más atención, suscitando el descubrimiento de nuevas aplicaciones siempre en constante actualización. Por ello, es necesario entender qué es el sistema CRISPR-Cas desde sus bases, estando atentos a sus avances en el futuro.
Prevalencia de anemia, leucopenia y trombocitopenia en una población adulta en el servicio de hospitalización de una institución prestadora de servicios de salud de tercer nivel, Sincelejo-Sucre
Authors:   Médico. Grupo de Ciencias Médicas y Farmacéuticas. Universidad de Sucre, Sincelejo, Colombia, Tovío-Martínez Irene
Published: June 2024

Introducción: La anemia es uno de los problemas de salud pública más graves a nivel mundial, con una prevalencia en la población general del 24,8%. La leucopenia constituye un 5% aproximadamente de las consultas en el servicio de hematología, puede presentarse como un proceso secundario a una patología y en menor grado a alteraciones propias del sistema hematológico. El 0,9% de los pacientes con una enfermedad aguda, y cerca del 25% al 46% de los pacientes en unidad de cuidados intensivos, presentan algún grado de trombocitopenia. Estas alteraciones hematológicas constituyen las principales causas de problemas de salud pública. Objetivo: Caracterizar la anemia, la trombocitopenia y la leucopenia en una población adulta del Servicio de Hospitalización de la Clínica las Peñitas, Sincelejo-Sucre, durante el periodo comprendido entre el 01 junio de 2017 al 01 mayo de 2018. Metodología: Este estudio es una investigación de tipo cuantitativo, observacional descriptivo, retrospectivo de tipo transversal, no experimental. Se revisaron 524 historias clínicas de las cuales 447 cumplían los criterios de inclusión. Para el análisis de las variables se tabularon los datos, se obtuvo la prevalencia mediante la fórmula para el cálculo de prevalencia de periodo. Resultados: Se identificó que el mayor porcentaje de pacientes fueron de sexo masculino, procedentes del municipio de Sincelejo, cuyo principal trastorno hematológico fue la anemia. Conclusiones: Se pudo identificar que el trastorno más frecuente es la anemia, la relación que existe entre su presentación a un mayor rango de edad de los pacientes nos alerta acerca de la importancia de realizar tamizajes y manejos profilácticos. Esto abre una ventana a un manejo más oportuno de los pacientes y un mejoramiento de su calidad de vida.