bluuebunny/crossref_metadata_2025 huggingface dataset:
VETERINARY AND SANITARY EXAMINATION OF YAROK MEAT WHEN USING UVMC «VITA BALANCE»
Authors:   FSBEI HE ", Khairullin D.D. ,   Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Papunidi E.K. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Shakirov Sh.K. ,   Federal State Budgetary Scientific Institution "Tatar Research Institute of Agriculture" FRC KazSC RAS
Published: June 2021

The purpose of the study was to study the effect of UVMC "Vita Balance" on the quality in-dicators of veterinary and sanitary examination of Yarok meat, in the conditions of scientific and economic experience. To do this, two groups of bright spots were selected using the method of ana-log pairs-an experimental group and a control group. Animals of the experimental group were given free rein for 45 days to lick the UVMC "Vita Balance". Research on veterinary and sanitary exami-nation of yark meat was conducted in the laboratory of veterinary and sanitary examination of the Kazan gavm. Analysis of the obtained results confirmed that when using the new feed additive UVMC "Vita Balance" in feeding yarkas, the daily need for the actual feeding ration in the conditions of this farm was 25.5±1.6 g per day per head. The results of veterinary and sanitary examination of yark meat by organoleptic, physico-chemical and bacteriological indicators of yark meat of control and experimental groups are fresh and had no distinctive features.
THE USE OF A PHYTOPREPARATION FROM HORSERADISH ROOT FOR THE TREATMENT AND PREVENTION OF POSTPARTUM CATARRHAL-PURULENT ENDOMETRITIS IN COWS
Authors:   FSBEI HE ", Khalipaev M.G. ,   Dagestan State Agrarian University named after M.M. Dzhambulatov ", Zukhrabov M.G. ,   FSBEI HE "Dagestan State Agrarian University named after M.M. Dzhambulatov ", Azizov I.M. ,   FSBEI HE "Dagestan State Agrarian University named after M.M. Dzhambulatov ", Zukhrabova Z.M. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman "
Published: June 2021

Intrauterine administration of a phytopreparation from horseradish root for 5-6 consecutive days once a day for 100 ml contributed to the treatment of catarrhal-purulent endometritis in cows, the restoration of the uterine mucosa occurred gradually and was completed by the time of 36-40 days from the start of the course of treatment. The introduction of a phytopreparation immediately after the separation of the afterbirth or the provision of obstetric care for 100 ml for 2-3 days in a row, allowed to prevent the development of catarrhal-purulent endometritis.
LACTIVE ACTIVITIES OF FIRST-CALF COWS USING ROBOTIC MILKING
Authors:   FSBEI HE ", Khisamov R.R. ,   Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Zagidullin L.R. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Kayumov R.R. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman "
Published: June 2021

Studies have been conducted to assess the lactation productivity of Kholmogory breed Tatarstan type first-calf cows with robotic milking systems. The frequency of milking distribution during the day was observed: in the interval of 4-6 hours, the minimum number of milking occurs (6.4 %), in the interval of 12-14 hours, the maximum number (10.7 %). Most milking (34.7 %) is carried out in 6-8 hours after the previous one. More frequent milking (after 4-6 hours) is rarely observed is in 6 % of cases. 48.6 % of milking occurs after the 8-12 hour interval. For an interval of more than 12 hours occurs for 10.7 % of milking. With an increase in the milking interval, the milk yield also increases. At 4-6 hour interval, the milk yield is 5.2 kg, at 6-8 hour is 6.0 kg. An increase in the milking interval by 2 hours is accompanied by an increase in the single milk yield by 0.8-1.3 kg. During the first month, the cows were milked the least number of times, which was 75, or 2.4 times per day; during the second month, they were milked 86 times (2.8 per day). By the 4th month, milkings reached a peak of 93 times (3 per day). By the 5th month, a decline was observed (by 11 % compared to the 4th month). The peak milk production takes place during the second month of lactation, 681.3 kg. By the third month, a decline was observed by 4.8 %, to 648.1 kg. The maximum decrease in milk production, by 12.4 %, occurred between the 5th and 6th month of the tested lactation period.
THE INFLUENCE OF THE PHYSIOLOGICAL STATE OF RABBITS ON HEMATOLOGICAL INDICATORS WITH CHANGES IN THE AREA OF THE PLANTARY SURFACE OF THE FEET
Authors:   FSBEI HE ", Khokhlova N.S. ,   Belgorod State Agrarian University named after V.Ya. Gorin ", Semenyutin V.V. ,   FSBEI HE "Belgorod State Agrarian University named after V.Ya. Gorin "
Published: June 2021

The influence of the physiological state of rabbits (pregnancy and lactation) on the hematological parameters of blood during changes in the area of the plantar surface of the feet of the hind limbs in conditions of cage keeping was studied. In the body of pregnant females, with the appearance of signs of hyperkeratosis and alopecia in the studied area of the feet, an increase in hemoglobin level occurs, an increase in MCH (mean corpuscular hemoglobin), MCV (Mean Corpuscular Volume), MCHC (corpuscular hemoglobin concentration) occurs, followed by a decrease in the development of hemorrhagic changes. The level of red blood cells has slight fluctuations. In lactating females, with the occurrence of alopecia and hyperkeratosis, an increase in the level of erythrocytes and hematocrit occurs with a simultaneous decrease in hemoglobin, and against the background of the development of hemorrhages, these indicators decrease, a decline in the values of MCH, MCHS and an increase in MCV are recorded. Regardless of the physiological state of the animal and changes in the area of the feet, the erythrocyte sedimentation rate (ESR) value and the level of leukocytes fluctuate within the limits of physiological values, which indicates the absence of an inflammatory process in the body. he revealed hematological changes indicate the development of adaptive processes in the event of hyperkeratosis and alopecia in the area of the plantar surface of the feet at various physiological conditions of rabbits with subsequent decompensating against the background of hemorrhagic changes.
THE INTENSITY OF GROWTH AND DEVELOPMENT OF QUAILS WHEN USING A NANOSTRUCTURED PREPARATION
Authors:   GBU ", Bozova G.B. ,   State Veterinary Association of Kazan", Girfanov A.I. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Naumova O.I. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Istomina A.S. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman "
Published: June 2021

The article is devoted to the study of the intensity of growth and development of quails us-ing a nanostructured preparation. The object of the study was the Texas white quail (n = 45), at the age of 10 days, which were divided into 1 control and 4 experimental groups. Birds from the exper-imental groups were given a complex preparation in various doses and forms to the main diet, con-sisting of compound feed DK-52. It was found that birds are intensively gaining live weight in the first 28 days of feeding. The average daily gains in live weight increased in quails from group 1 by 8.3 %, group 2 – 12.9 %, group 3 – 3.8 % and group 4 – 24.9 % compared with birds of the control group. Starting from the 35th day, there is a decrease in the average daily gain. The best results for both 28 and 56 days were shown by quails in group 4, which received a complex preparation at a dose of 1 % of the diet weight.
JUSTIFICATION OF THE APPLICATION COMPLEX PREPARATION «FERORSEL» IN PIG BREEDING
Authors:   FSBEI HE ", Gasanov A.S. ,   Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Zukhrabova Z.M. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Aslanov R.M. ,   FGBNU "Federal Center for Toxicological, Radiation and Biological Safety", Tamimdarov B.F. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman "
Published: June 2021

It is experimentally proved that the use of the drug "Ferorsel", containing a complex of iron succinate with organic selenium and the development of optimal modes of use show a positive trend in the treatment and prevention of anemia in piglets, as well as in increasing the resistance of the body of sick animals. Thus, the use of this drug in pregnant sows contributed to the normal course of pregnancy and the prevention of alimentary iron deficiency anemia in suckling pigs. Further use of the drug throughout the lactation period contributed to the normalization of hematopoiesis, iron metabolism in the body and improvement of the productive qualities of sows, as well as an increase in the level of bactericidal, lysozyme activity of blood serum and phagocytic activity of neutrophils.
INFLUENCE OF «YANTOVET» ON THE MEAT PRODUCTIVITY OF RABBITS
Authors:   FSBEI HE ", Arkhipova S.P. ,   Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Yakupova L.F. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman ", Gracheva O.A. ,   FSBEI HE "Kazan State Academy of Veterinary Medicine them. N.E. Bauman "
Published: June 2021

The introduction of «Yantovet» into the diet of rabbits at a dose of 0,33 ml per 1 kg of live weight has a stimulating effect on the intensity of their growth and productivity. By the end of the experiment, the live weight of the experimental group was higher than that of the control by 13 %. The average daily gain for the entire period of experiments in the experimental group exceeded the same indicator in the control by 38,7 %. The rabbits of the experimental group had a higher level of productivity, as the slaughter weight and slaughter yield of rabbit carcasses in the experimental group in relation to the control group were higher by 16,6 and 2,9 %. The study drug is recom-mended to be used in the diet of rabbits in the composition of drinking water.
PLATELET HEMOSTASIS AND ITS RELATIONSHIP WITH CORTISOL AND PROGESTERONE IN COWS DURING PREGNANCY
Authors:   FSBEI HE ", Derkho M.A. ,   South Ural State Agrarian University", Sled A.N. ,   FSBEI HE "South Ural State Agrarian University", Derho A.O. ,   FSBEI HE "South Ural State Agrarian University"
Published: June 2021

The assessment of the state of platelet hemostasis in the body of cows of Auliekol and black-and-white breeds in the last trimester of pregnancy and the relationship of its indicators with the level of cortisol and progesterone is given. Laboratory tests were performed 60 and 1-3 days before the expected date of delivery. It was found that the breed of cows affected the level of platelet parameters. At the same time, their value in the blood of cows of the Auliekol breed exceeds the level of animals of the black - and - white breed by 3.15-31.89 %. The dynamics of changes in platelet parameters during the preparation of the mother's body for childbirth is of the same type and is characterized by a decrease in the total number of platelets by 11.74 and 24.14% and their volume fraction in the blood (thrombocrit) by 6.45 and 12.00 %, respectively. At the same time, the average platelet volume, the number of megalothrombocytes and the breadth of their distribution by volume increases by 6.83; 16.37 and 14.94 % (in the Auliekol breed) and 15.49; 16.01 and 17.19 % (in the black-and-white breed). These changes are associated with the level of the hormones cortisol and progesterone, the biological effects of which involve the regulation of platelet aggregation by controlling the level of young cells (megalothrombocytes) in the blood of cows. This is evidenced by statistically significant values of correlation coefficients in pairs of signs: cortisol-P-LGR r=0.72±0.24-0.88±0.17; progesterone-P – LGR r=-0.72±0.24 – -0.83±0.20.
INTRA-LINEAR SELECTION AND CROSS-LINE SELECTION WHEN CREATING HIGHLY PRODUCTIVE DAIRY CATTLE HERDS
Authors:   FSBEI HE ", Ignatieva N.L. ,   Chuvash State Agrarian University", Voronova I.V. ,   FSBEI HE "Chuvash State Agrarian University", Nemtseva E.Yu. ,   FSBEI HE "Chuvash State Agrarian University"
Published: June 2021

The aim of the research was to evaluate the compatibility of lines and improve on this basis the traditional selection methods for creating breeding herds in dairy cattle breeding. The results of the analysis showed that the best milk yield among the other lines were the first-born heifers (n=39) of the Holstein line Vis Back Idial (6441 kg of milk). The analysis of the results of the intra-linear selection showed that the best milk yield was also distinguished by the first-born heifers of the Vis Back Idial line – 6721 kg of milk. Analyzing the cross-line of the Vis Back Idial with other lines of the Holstein breed (MCH, RS, and PG), it should be noted that they are superior to their first-calf peers by 253-530 kg of milk. The first-calf cows, derived from the cross of the Montwick Miftaine line and the Reflection Sovering and Pabst Governer lines, also have some superiority over their peers. Thus, when improving breeding herds of dairy cattle, it is necessary to use both intra-linear selection and cross-lines, taking into account their compatibility.
Produksi Serasah dan Laju Dekomposisi Thalassia hemprichii dan Cymodocea rotundata di Perairan Malang Rapat, Kabupaten Bintan
Authors: Kristina Kariska , Lestari Febrianti , Nugraha Aditya Hikmat
Published: June 2021

Penelitian mengenai produksi serasah dan laju dekomposisi Thalassia hemprichii dan Cymodocea rotundata  telah dilakukan di Perairan Desa Malang Rapat Kecamatan Gunung Kijang Kabupaten Bintan. Tujuan penelitian ini adalah mengetahui tutupan jenis T. hemprichii dan C. rotundata, mengetahui produksi jenis T. hemprichii dan C. rotundata dan mengetahui laju dekomposisi lamun jenis T. hemprichii dan C. rotundata. Penelitian  ini di lakukan  dengan metode purposive sampling. Hasil penelitian tutupan lamun di Perairan Desa Malang Rapat Kecamatan Gunung Kijang Kabupaten Bintan stasiun satu jenis T. hemprichii dengan tutupan lamun perjenis sebesar 8,51%, sedangkan C. rotundata 8,50%. Jika dilihat dari nilai total tutupan lamun sebesar 39,4% dikategorikan sedang, stasiun dua tutupan lamun   perjenis T. hemprichii berkisar 6,41%, sedangakan C. rotundata berkisar 5,65% dan total tutupan  sebesar 29,49%. Produksi serasah di Perairan Desa Malang Rapat Kecamatan Gunung Kijang Kabupaten Bintan pada stasiun satu T. hemprichii  dan C. rotundata mengalami kenaikan dibandingkan pada stasiun dua. Laju dekomposisi pada stasiun dua T. hemprichii dan C.  rotundata mengalami laju dekomposisi lebih cepat dibandingkan stasiun satu.
The Relevansi Pemikiran Paulo Freire dengan Kemampuan Berpikir Kritis Matematis Siswa Sekolah Menengah Pertama
Authors: Syarifuddin Syarifuddin
Published: June 2021

Penelitian ini dilakukan untuk melihat dan mendeskripsikan pemikiran Paulo Freire dan kemampuan berpikir kritis matematis siswa sekolah menengah pertama (SMP) serta untuk melihat ada tidaknya relevansi atau hubungan antara keduanya. Penelitian ini menggunakan metode penelitin kualitatif dengan desain kepustakaan. Data dalam penelitian ini terdiri dari data primer (utama) yang diperoleh dari buku, pemikiran dan karya yang ditulis Paulo Freire dan data sekunder sebagai data pendukung dari data primer yang diperoleh dari jurnal, buku dan laporan hasil penelitian yang relevan. Analisis data yang digunakan dalam penelitian ini adalah analisis deskriptif, dimana data diolah dan dianalisis sesuai dengan studi literatur yang sudah dikumpulkan dan kemudian dideskripsikan untuk memperoleh hasil dan kesimpulan. Hasil dari penelitian ini adalah adanya relevansi antara pemikiran Paulo Freire dan kemampuan berpikir kritis matematis siswa SMP diantaranya yaitu, (1) dalam pembelajaran matematika, siswa diberikan kebebasan untuk mengembangkan kemampuan berpikir kritis melalui metode inquiry dan dialog terbuka yang sesuai dengan konsep pendidikan humanis Paulo Freire, (2) standart isi pelajaran matematika sekolah dasar dan menengah yang menuntut adanya perkembangan berpikir kritis dalam diri siswa yang sejalan dengan buah pemikiran dari Paulo Freire, (3) memposisikan siswa sebagai partner belajar atau subjek di dalam proses pembelajaran.
Technologieblockchainet intermédiation dans l’industrie musicale
Authors: Bach Laurent , Guichardaz Rémy , Schenk Éric
Published: June 2021

Les évolutions technologiques récentes ont entraîné une remise en cause des activités d’intermédiation des acteurs dominants de l’industrie musicale. Après une réorganisation de leurs ressources et de leurs compétences, ces dernières ont su redéployer leurs fonctions autour de stratégies à 360°. Parmi les technologies émergentes, lablockchainest souvent présentée comme un outil de désintermédiation. En effet, elle permet de stocker des informations ou d’effectuer des transactions sans recourir à un organe central de contrôle. À l’aide d’une méthodologie qualitative, cet article propose une analyse prospective de l’impact de lablockchainsur l’intermédiation au sein de l’industrie musicale.
Alienation among Management Scholars
Authors: Le Breton-Miller Isabelle , Miller Danny
Published: June 2021

In a conceptual synthesis of a large body of literature, we explore drivers of alienation among management scholars through the lens of a classical path goal motivational model. Some scholars have become alienated from doing research due to the socio-political context of publishing. Although their unitary complaints are irksome, collectively these can amount to a career gauntlet – “a perfect storm” – of compounding challenges that permanently drive away scholars from doing academic research. To better understand this process, we show the pernicious interplay of these challenges in an expectancy model of costs, risks and rewards, each manifesting several of Blauner's (1964) drivers of work alienation – meaninglessness, powerlessness, self-estrangement and isolation. We conclude by suggesting mitigating conditions, summary propositions, and remedial implications.
Aeromobilities of Student Newcomers in Francophone African Fiction
Authors: Toivanen Anna-Leena
Published: June 2021

In the field of postcolonial literary studies, representations of concrete forms of mobility have not received the critical attention they deserve. This is partly due to the field’s reductive understanding of “mobility” as a synonym for migration. In order to enhance dialogue between postcolonial literary studies and mobilities research, this article focuses on representations of aeromobility in the context of Afroeuropean student mobilities in a set of Francophone African novels from the 1980s to the 2010s. My reading of scenes of aeromobility in the text corpus draws attention to the anxious aspects of the air travel of unaccustomed travelers and African newcomers traveling to the former colonial center, and explores the formal functions of representations of aeromobility in terms of narrative structures and tropes.
Book Reviews
Authors: Baker Lucy , Castañeda Paola , Dalstrom Matthew , Datta Ankur , Joelsson Tanja , Jordi-Sánchez Mario , Kelly Jennifer Lynn , Zunino Singh Dhan
Published: June 2021

Nicholas A. Scott, Assembling Moral Mobilities: Cycling, Cities and the Common
Good (Lincoln: University of Nebraska Press, 2020), 288 pp., 38 illus., $50

John Stehlin, Cyclescapes of the Unequal City: Bicycle Infrastructure and Uneven
Development (Minneapolis: University of Minnesota Press, 2019), 328 pp., 24 photos, 11 maps, 9 tables, $27

Cecilia Vindrola-Padros, Critical Ethnographic Perspectives on Medical Travel (New York: Routledge, 2019), 161 pp., $36.77

Nicola Frost and Tom Selwyn, eds., Travelling Towards Home: Mobilities and Homemaking (New York: Berghahn, 2018), 182 pp., 10 illus., 1 table, $110

Peter Cox, Cycling: A Sociology of Vélomobility (Abingdon: Routledge, 2019), 200 pp., 2 B/W illus., £120.00 (ebook £40.49)

Lesley Murray and Susana Cortés-Morales, Children’s Mobilities: Interdependent, Imagined, Relational (London: Palgrave Macmillan, 2019), 307 pp., 10 illus., $89.99

Jocelyne Guilbault and Timothy Rommen, eds., Sounds of Vacation: Political Economies of Caribbean Tourism (Durham, NC: Duke University Press, 2019), 234 pp., $25.95

John Krige, ed., How Knowledge Moves: Writing the Transnational History of Science and Technology (Chicago: Th e University of Chicago Press, 2019), 408 pp., 11 illus., $40
ENERJİ EĞİTİMİ: META SENTEZ ÇALIŞMASI
Authors: BOZ Vildan , COŞTU Fatma
Published: June 2021

Bu çalışma, Türkiye’de enerji eğitimi konusu ile ilgili yazılmış ve yayımlanmış makale ve lisansüstü tezlerin belirlenen temalar doğrultusunda meta-sentez yöntemi ile incelenmesi sonucunda literatürde yer alan çalışmalara toplu bir bakış açısı sağlamak amacıyla yapılmıştır. Araştırmada, nitel ve karma araştırma yöntemiyle çalışılmış olan 7 makale ve 17 lisansüstü tez olmak üzere toplam 24 çalışma analiz edilmiştir. İncelenecek araştırmaların seçiminde Yüksek Öğretim Kurumu (YÖK) Ulusal Tez Tarama Merkezi, DergiPark ve ProQuest veri tabanlarından yararlanılmıştır. Araştırmada geçerlilik ve güvenirliliği sağlamak için çalışmanın amacı ve araştırma soruları açık bir şekilde ifade edilmiş ve inceleme kategorilerinin oluşturulması ve incelenecek çalışmaların belirlenmesi sürecinde belirli aralıklarla makale yazarları, alan uzmanı ve doktora öğrencileri uzaktan erişimle toplantılar gerçekleştirmiştir. Araştırmada elde edilen veriler, enerji eğitimi ile ilgili çalışmaların yıllara göre dağılımları, hedeflenen amaçlar, tercih edilen araştırma desenleri, örneklem grubu, veri toplama aracı, araştırmada elde edilen sonuçlar ve çalışmalarda verilen öneriler açısından değerlendirilmiştir. Elde edilen veriler tablo ve grafikler yardımıyla yorumlanmıştır. Araştırmada, Türkiye’de enerji eğitimi ile ilgili yapılan çalışmaların 2016 ve sonrasında yoğunlaştığı tespit edilmiştir. Bunun yanı sıra yapılan araştırmaların, enerji eğitimi ve enerji konularına yönelik görüş, tutum ve davranışları belirleme, katılımcıların enerji ile ilgili farkındalıkları ve bilişsel yapılarına etkisini belirlemek amacıyla yapıldığı belirlenmiştir.
PENGARUH KUALITAS PELAYANAN DAN KEPUASAN NASABAH TERHADAP LOYALITAS NASABAH TABUNGANMU MANDIRI KCP SIMPANG TIGA PASAMAN BARAT
Authors: Mantauv Citra Suci
Published: June 2021

ABSTRAK Loyalitas adalah ditujukan kepada suatu perilaku atau sifat, yang ditunjukan kepada kestiaan konsumen dan merekomendasikan produk perusahaan kepada orang lain. Penelitian ini bertujuan untuk menganalisa bagaimana pengaruh Kualitas Pelayanan dan Kepuasan terhadap Loyalitas nasabah TabunganMu Bank Mandiri KCP Simpang Tiga, jumlah sampel pada penelitian ini sebanyak 100 Responden. Pengujian hipotesis yang digunakan dengan regresi berganda dengan hasil Kualitas Pelayanan berpengaruh Positif dan Signifikan dengan nilai 0.436 dan nilai signifikan sebesar 0.000 ( < 0.05). Kepuasan berpengaruh positif dan signifikan dengan nilai 0.530  dan nilai signifikan sebesar 0.000 ( < 0.05 ). Nilai koefisien Determinasi sebesar 90.4% di pengaruhi Kualitas Pelayanan dan Kepuasan, sedangkan sisanya dipengaruhi oleh faktor lainnya. Kata Kunci  : Loyalitas Nasabah, Kualitas Pelayanan, Kepuasan ABSTRACT Loyalty is aimed at a behavior, which is indicated by repeated purchases and recommending company products to friends or partners. This study aims to analyze how the influence of Service Quality and Customer Satisfaction on Customer Loyalty on Customer Loyality of Tabunganmu Bank mandiri KCP of Simpang Tiga, the number of samples in this study were 100 Respondents. Hypothesis testing used by multiple regression with the results of Service Quality has a positive and significant effect with a value of 0.436 and a significant value of  0.000 (<0.05). The Customer Satisfaction is positive and significant with a value of 0.530 and a significant value of 0.00 (<0.05). Determination coefficient value of 90.4% is influenced by the Service Quality and Customer Satisfaction, while the rest is influenced by other factors.Keywords: Customer Loyality, Service Quality, Customer Satisfaction
Imitação na Ars Politica de Maquiavel: ambiguidades e ambivalências na reinserção da Virtù
Authors: De Assis Jean Felipe
Published: June 2021

A adequação dinâmica dos bons exemplos, conformando-os às necessidades impostas pelas circunstâncias, insere Maquiavel nos variados usos da imitatio antiga e renascentista. A imitação deve reavivar as práticas civis e as atitudes de Virtù, fornecendo ânimo para a realização das ações políticas e das práticas pedagógicas, conforme a atuação como secretário de Florença e seus escritos políticos, históricos e literários salientam. Desse modo, ao revisar a noção de imitatio, especificamente na antiguidade e na renascença, contextualizam-se os argumentos de Maquiavel sobre a possibilidade dos humanos alcançarem a Virtù pela imitação das ações adequadas nos Discorsi, no Príncipe, nas Histórias Florentinas e na Arte da Guerra.  Ao propor investigações e análises do passado que produzam utilidade e deleite, realçando o sabor das ações humanas, os escritos Maquiavelianos realçam a impossibilidade de uma definição pré-determinada sobre quais opções devam ser usadas (ambiguidade) e sustentam a possibilidade de duas perspectivas, aparentemente antagônicas, serem escolhidas simultaneamente (ambivalência).
Gilles Deleuze e Aristóteles: a diferença no feliz momento grego
Authors: Farias Rezino Larissa
Published: June 2021

As críticas deleuzianas ao pensamento representacional convergem para o entendimento do pensamento como um processo recognitivo. Reconhecer é pensar. Entre todos os problemas concernentes a tal modelo de pensamento, há um empecilho fundamental na recognição: ela não reconhece aquilo que não cabe em suas premissas previamente estabelecidas e que delimitam a linearidade de um pensamento correto. Assim sendo, a diferença, nos alerta Deleuze, nunca chegou a ser pensada por si mesma. Nessa noção a diferença é apenas uma oposição ao igual. Em um dos seus diálogos com a tradição filosófica, o pensador francês encontrou uma rachadura pontual que tratou a diferença no pensamento do filósofo grego Aristóteles. Um momento em que a diferença emergiu e quase foi considerada por si mesma. Ocasião que Deleuze chamou de “O feliz momento Grego”. É sobre o pensamento aristotélico da diferença, o tal momento grego e a crítica conceitual que Deleuze realiza para compor sua teoria que o artigo irá tratar.
Subjetividade e desamparo: um olhar winnicottiano sobre a racionalidade neoliberal
Authors: Andrade Almeida Flávia , Sampaio de Freitas Felipe
Published: June 2021

Entendemos os eventuais problemas em discutir subjetividades a partir dos escritos de dois pensadores tão diferentes como Foucault e Winnicott, mas nesse estudo, o objetivo é fornecer um possível contraponto winnicottiano para as análises realizadas por Foucault a respeito da subjetividade na racionalidade neoliberal. Nossa proposta é pensar a constituição da subjetividade na racionalidade política neoliberal, que conforme verificamos, constrói indivíduos psiquicamente voltados para certo individualismo em detrimento da ética e da alteridade. Após uma discussão sobre a dinâmica da formação do capital humano, conforme apresentado por Foucault, e da apresentação das noções fundamentais acerca dessa constituição específica da subjetividade, realizamos um contraponto apresentando os pontos fundamentais da teoria do amadurecimento de Winnicott para pensar a respeito de possíveis consequências psíquicas que a racionalidade neoliberal, produtora de sujeitos voltados para a competição, impõe a essas estruturas subjetivas.
Flusser’s radical immanent monism
Authors: Dias da Silva Wanderley
Published: June 2021

Starting from Flusser’s most explicit statements about irony, self-irony, and the Devil, I try to make some sense of the relations, in Flusser’s thought, between language, reality and scepticism. And, perhaps most importantly, I try to clarify Flusser’s notion of the role of philosophy proper. This analysis will bring us to a puzzling spectrum I see hovering over Flusser’s ideas: the eradication of boundaries between the ontological and the ethical. That is what I call Flusser’s radical immanent monism.
Límites que discurren como umbrales: Walter Benjamin y la crítica de la razón moderna
Authors: Moreno María Rita
Published: June 2021

El objetivo de este artículo consiste en examinar la incardinación de la noción crítica “límite de la razón” y la noción dialéctica “umbral” en el marco de la filosofía de Walter Benjamin. A tal fin, en primer lugar, se indaga la determinación benjaminiana de los límites racionales conforme a la correlación entre el debilitamiento de la experiencia mimética y la instrumentalización del lenguaje. Luego, a partir de un análisis de la dialéctica de los medios, se indica por qué la filosofía benjaminiana puede ser concebida como el intento por transformar dialécticamente los “límites de la razón” en “umbrales” abiertos a otra experiencia racional. De esta manera, se espera mostrar un aspecto del pensamiento de Walter Benjamin: la actualización de la crítica de la razón como uno de los fundamentos de su programa para una filosofía venidera.
Los impulsos en la concepción materialista de la razón de Max Horkheimer
Authors: García Cherep Paula
Published: June 2021

El presente trabajo aborda la relación entre la noción de razón (Vernunft) y la de impulsos (Triebe) en Max Horkheimer. Nos centraremos principalmente en el análisis de dos de sus artículos de la década de 1930 para señalar que el filósofo rechaza la idea -propia de la concepción burguesa de razón- según la cual razón e impulsos son radicalmente opuestos entre sí, ya que mediante ella se suele fundamentar la represión de lo impulsivo en nombre de una optimización del pensamiento. Horkheimer entiende que mientras tal represión pretende emancipar a la razón respecto de lo otro de ella, en realidad no hace más que producir una atrofia del pensamiento. Nos proponemos demostrar que Horkheimer concibe a esa oposición radical como falsa por dos motivos: por un lado, por el hecho de que la razón misma adquiere un comportamiento impulsivo cuando se identifica con el pensamiento y busca reprimir todo lo que considera distinto de él. Por otro lado, porque sin un vínculo consciente de la razón con lo impulsivo, ella queda presa de la irracionalidad. Sostenemos que hay en Horkheimer una concepción materialista de la relación entre las nociones de impulsos y razón, según la cual sólo el establecimiento de una relación consciente entre ambos, que no descuide la satisfacción de las demandas impulsivas, puede evitar que el pensamiento se torne irracional.
Horizontes trágicos del cuerpo: la invención en Aimé Césaire y Frantz Fanon
Authors: Aguirre Aguirre Carlos
Published: June 2021

El trabajo aborda los problemas de la tragedia, la invención y el cuerpo colonizado en las escrituras de los pensadores martiniqueses Aimé Césaire y Frantz Fanon. Para ello, en un primer momento nos detenemos en el vínculo que existe entre la tragedia de las experiencias de los cuerpo negros aludidos en las escrituras de los mentados autores con los controles y reificaciones de la modernidad colonial. En un segundo momento, discutimos la invención de la imagen poética de Cuaderno de un retorno al país natal de Césaire y cómo desde ella sobresale la agencia de un cuerpo propio en una reescritura crítica del Triángulo Atlántico. A continuación, en un tercer apartado, reflexionamos sobre la experiencia vivida de Fanon en su trabajo Piel negra, máscaras blanca con el objetivo de rastrear su talante trágico, autodestructivo, y su potencia inventiva. Finalmente se concluye que Césaire y Fanon hacen de la invención una posibilidad de construir otra imaginación histórica del cuerpo por fuera de los ordenamientos raciales de la modernidad colonial.
Energiemanagement
Authors: Hubbuch Markus , Jäschke Brülhart Stefan
Published: June 2021

Dieses Buch vermittelt Grundlagen, Methoden und Zusammenhänge des Energiemanagements. Es werden wichtige Begriffe, neue Techniken, Anwendungen und Hilfsmittel erklärt. Das Verständnis grundlegender physikalischer Zusammenhänge ermöglicht einfache Berechnungen und Vergleiche. Checklisten helfen bei der Umsetzung und erleichtern es, wichtige Entscheidungen im Hinblick auf Planung und Betrieb zu fällen. Die Publikation richtet sich an alle, die mit Bau, Betrieb und Erhaltung von Gebäuden zu tun haben. Insbesondere Betreiber von Gebäuden, Planerinnen, Facility Manager, Verwalter, Architektinnen und Bauherren können profitieren. Das Buch fokussiert auf Themen des Managements und der energetischen Betriebsoptimierung, um ein systematisches Vorgehen und einen nachhaltigen Erfolg des Energiemanagements zu ermöglichen. Damit wird das Gelingen der Energiewende und der Klimaziele wirksam unterstützt. Derzeit wird die grösste Energiemenge im Gebäudebereich verbraucht. Mit einem zielgerichteten Management des Gebäudebetriebs sowie mittels Energiemanagement können wesentliche Einsparpotenziale realisiert werden. In kurzer Zeit und mit vergleichsweise wenig Investitionen können Kosten gespart und Treibhausgasemissionen verringert werden.
TÜRKÇENİN YABANCI DİL OLARAK ÖĞRETİMİNDE ÖĞRENME AMAÇLI MEKTUP YAZMA ETKİNLİĞİNİN KULLANILMASI
Authors: GÜVEN Ahmet Zeki , ALTAY Merve
Published: June 2021

Bu araştırmanın amacı, Akdeniz Üniversitesi TÖMER’de 2018-2019 eğitim-öğretim yılında A2, B1 ve B2 seviyelerinde Özel ve YTB gruplarında yabancı dil olarak Türkçe öğrenen öğrencilerin Türkiye’yi ve Türk kültürüne ait ögeleri öğrenme ve kültürlerarası etkileşim durumlarının öğrenme amaçlı mektup yazma etkinliği ile belirlenerek incelenmesidir. Araştırmanın modeli nitel araştırma desenlerinden durum çalışmasıdır. Araştırmanın çalışma grubunu Antalya ilinin Konyaaltı ilçesinde bulunan Akdeniz Üniversitesi TÖMER’de 2018-2019 eğitim-öğretim yılında yabancı dil olarak Türkçe öğrenen 45 kadın ve 45 erkek olmak üzere toplam 90 öğrenci oluşturmaktadır. Araştırmada veri toplama aracı olarak araştırmacılar tarafından geliştirilen öğrenci tanıma formu ve öğrenci çalışma formu kullanılmıştır. Verilerin toplanmasında doküman analizi tekniğinden yararlanılmıştır. Öğrencilerle iki ay arayla üç uygulama yapılmıştır. İlk uygulama 32 A2 Özel ve 21 A2 YTB öğrencisiyle, ikinci uygulama 27 B1 Özel ve 22 B1 YTB öğrencisiyle, üçüncü uygulama ise 20 B2 Özel ve 22 B2 YTB öğrencisiyle gerçekleştirilmiştir. Uygulama süreçlerinde öğrencilere uygulama hakkında bilgi verilmiş ve öğrencilerden sevdikleri bir arkadaşlarına Türkiye’yi ve Türk kültürünü tanıtan bir mektup yazmaları istenmiştir. Araştırmada elde edilen veriler araştırmacı tarafından toplanmış ve içerik analizi tekniği ile çözümlenmiştir. Altı grubun her birinden 15 tane olmak üzere 90 mektup seçilmiştir. Mektuplarda konuyla ilgili geçen cümleler tespit edilerek kültürel ögeler belirlenmiş ve 11 tema oluşturulmuştur. Veriler bu temalar çerçevesinde incelenmiştir.

Araştırma sonucuna göre, öğrencilere bunun bir sınav olmadığının belirtilmesi ve öğrencilerin mektup yazmak için sevdikleri bir arkadaşlarını muhatap seçmesi; öğrencilerin mektuplarını yazarken samimi davranmasında, konuyla ilgili bildiklerini mektuplarında rahatça ifade etmesinde etkili olmuştur. Ayrıca tüm seviye ve gruplarda kız öğrencilerin erkek öğrencilere göre aktarımlarının daha ayrıntılı olduğu görülmüştür.
Plasma Neurofilament Light and Future Declines in Cognition and Function in Alzheimer’s Disease in the FIT-AD Trial
Authors: Li Danni , Zhang Lin , Nelson Nathaniel W. , Mielke Michelle M. , Yu Fang
Published: June 2021

Background:

Utilities of blood-based biomarkers in Alzheimer’s disease (AD) clinical trials remain unknown.

Objective:

To evaluate the ability of plasma neurofilament light chain (NfL) to predict future declines in cognition and activities of daily living (ADL) outcomes in 26 older adults with mild-to-moderate AD dementia from the FIT-AD Trial.

Methods:

Plasma NfL was measured at baseline and 3 and 6 months. Cognition and ADL were assessed using the AD Assessment Scale-Cognition (ADAS-Cog) and AD Uniform Dataset Instruments and Disability Assessment for Dementia (DAD), respectively, at baseline, 3, 6, 9, and 12 months. Linear mixed effects models were used to examine the associations between baseline or change in plasma NfL and changes in outcomes.

Results:

Higher baseline plasma NfL was associated with greater rate of decline in ADAS-Cog from baseline to 6 months (standardized estimate of 0.00462, p = 0.02853) and in ADL from baseline to 12 months (standardized estimate of –0.00284, p = 0.03338). Greater increase in plasma NfL in short term from baseline to 3 months was associated with greater rate of decline in memory and ADL from 3 to 6 months (standardized estimate of –0.04638 [0.003], p = 0.01635; standardized estimate of –0.03818, p = 0.0435) and greater rate of decline in ADL from 3 to 12 month (standardized estimate of –0.01492, p = 0.01082).

Conclusion:

This study demonstrated that plasma NfL might have the potential to predict cognitive and function decline up to 12 months. However, future studies with bigger sample sizes need to confirm the findings.
A retrospective review of phyllodes tumors of the breast from a single institution
Authors: Yuniandini Ayu , Hamdani William , Prihantono Prihantono , Faruk Muhammad
Published: June 2021

BACKGROUND: Phyllodes tumors (PTs) are rare fibroepithelial breast tumors with diverse biological behavior. OBJECTIVE: This study aimed to analyze the characteristics, management, and outcome of phyllodes tumors. METHODS: Patients diagnosed with PTs in our institution from January 2013 to December 2017 were identified retrospectively by the ICD-10 code. Data were collected from medical records. The diagnosis of this tumor was based on histopathological results. Variables analyzed included age, tumor site, surgical option, axillary lymph nodes, chemotherapy and radiotherapy, metastases, disease-free survival (DFS), and overall survival (OS) rate. RESULTS: Sixty-nine cases of PTs were diagnosed during the period, of which 31 were benign, 38 were malignant, and 1 was a case of bilateral metachronous tumors. We did not find any borderline pathologic cases. The patient’s ages ranged from 20 to 71 years, with the highest number of cases (28) from the 40-49-year-old age group. The majority of patients (42) had PT on the right side. Simple mastectomy was the most performed treatment, with 53 such cases, including both benign and malignant. The axillary staging was carried out in 16 cases, of which none had nodal metastasis. Ten cases received chemotherapy, and 16 cases of malignant phyllodes received postoperative radiotherapy. We found 4 cases with distant metastases and 5 cases that developed local recurrence. The DFS rate reached 92.75%, and the overall 5-year survival rate was 84.21%. CONCLUSIONS: The incidence of PTs is highest in women in the 3rd and fourth decades of age. Simple mastectomy and wide excision are the treatments of choice, with a low recurrence rate in both benign and malignant PTs cases.
Prognostic and predictive significance of the tumor microenvironment in hepatocellular carcinoma
Authors: Liu Jibing , Kuang Shuwen , Zheng Yiling , Liu Mei , Wang Liming
Published: June 2021

BACKGROUND: Identification of molecular markers that reflect the characteristics of the tumor microenvironment (TME) may be beneficial to predict the prognosis of post-operative hepatocellular carcinoma (HCC) patients. OBJECTIVE AND METHODS: A total of 100 tissue samples from HCC patients were separately stained by immunohistochemistry to examine the expression levels of CD56, CD8α, CD68, FoxP3, CD31 and pan-Keratin. The prognostic values were analyzed by Cox regression and the Kaplan-Meier method. RESULTS: Univariate and multivariate logistic analysis showed that FoxP3 was the independent factor associated with microvascular invasion (MVI), tumor size and envelop invasion; CD68 was associated with envelope invasion and AFP. Kaplan-Meier survival curves revealed that CD68 and FoxP3 expression were significantly associated with relapse free survival (RFS) of HCC patients (P< 0.05). The ROC curve indicated that the combination of tumor number, MVI present and CD68 expression yielded a ROC curve area of 82.3% (86.36% specificity, 68.75% sensitivity) to evaluate the prognosis of HCC patients, which was higher than the classifier established by the combination of tumor number and MVI (78.8% probability, 63.64% specificity and 85.42% sensitivity). CONCLUSIONS: Our study indicated that CD68 and FoxP3 are associated with prognosis of HCC patients, and CD68 can be considered as a potential prognostic and predictive biomarker.
Profile of sphingolipid-related genes and its association with prognosis highlights sphingolipid metabolism in oral cancer
Authors: da Silva Gabriel , de Matos Leandro Luongo , Kowalski Luiz Paulo , Kulcsar Marco , Leopoldino Andreia Machado
Published: June 2021

BACKGROUND: Sphingolipids are bioactive lipids that play a role in cancer development. However, the clinical role of sphingolipid (SPL)-related genes in oral cancer (OC) remains not fully understood. OBJECTIVE: This study, aimed to examine the mRNA expression of 14 sphingolipid-related genes in oral cancer patients and their implication with clinicopathological features and prognosis. METHODS: qPCR analysis was performed in 50 OC tissues and their matched surgical margins. Next, Kaplan-Meier, Cox regression, and Receiver operating characteristics (ROC) analysis were applied to evaluate the impact of sphingolipid-related genes expression on the prognosis of OC. RESULTS: The genes SET, ACER3, SK1 and S1PR5 were predominantly up-regulated, while ABCG2, S1PR1, ABCB1 and SPNS2 were down-regulated in OC patients. Analyzing the Cancer Genome Atlas Head-Neck Squamous Cell Carcinoma (TCGA-HNSC) data, which are predominantly composed of OC samples, these genes displayed a similar profile. In OC patients, high levels of SK1 were associated with lymph node metastasis, extracapsular invasion, desmoplasia, locoregional relapse, and disease status. Low levels of SPNS2 were associated with lymph node metastasis, perineural invasion, and disease status. Furthermore, OC and HNSC patients with higher SK1 expression demonstrated shorter disease-free survival (p= 0.0037; p= 0.0087), whereas those with lower SPNS2 expression exhibited shorter overall survival (p= 0.051; p= 0.0012). High levels of ACER3 and low levels of S1PR1 were associated with shorter disease-free and overall survival in HNSC patients. CONCLUSION: Several sphingolipid-related genes are deregulated in OC at the mRNA level and are associated with clinicopathological features and presented potencial for the prediction of poor prognosis in OC patients.
Epigenetically-regulated serum GAS5 as a potential biomarker for patients with chronic hepatitis B virus infection
Authors: Guo Yong , Li Chunxue , Zhang Rongrong , Zhan Yating , Yu Jinglu , Tu Jinfu , Zheng Jianjian
Published: June 2021

BACKGROUND: Long non-coding RNA-growth arrest specific transcript 5 (lncRNA-GAS5) plays a suppressive role in activated hepatic stellate cells (HSCs). LncRNAs could circulate in the blood in a cell-free form and serve as promising biomarkers for various human diseases. Herein, we investigated the feasibility of using serum GAS5 as a biomarker for liver fibrosis in chronic hepatitis B (CHB) patients and whether promoter methylation was responsible for GAS5 down-regulation. METHODS: Serum GAS5 levels were quantified using quantitative real-time PCR in CHB patients and healthy controls. GAS5 promoter methylation was examined in LX-2 cells and cirrhotic tissues. RESULTS: Compared with the sera from healthy controls, lower GAS5 levels were found in the sera from CHB patients. Receiver operating characteristic curve analysis indicated that serum GAS5 had a significant diagnostic value for liver fibrosis in CHB patients. Serum GAS5 negatively correlated with HAI scores as well as ALT values in CHB patients. GAS5 was additionally reduced in cirrhotic tissues, associated with its hypermethylation promoter. In LX-2 cells, transforming growth factor-β1 treatment led to a reduction in GAS5 expression and an increase in promoter methylation. Hypermethylation of GAS5 was blocked down by DNA methyltransferase (DNMT) inhibitor and restored GAS5 inhibited HSC activation including proliferation and collagen production. Further studies confirmed that GAS5 methylation was mediated by DNMT1. CONCLUSION: We demonstrate that epigenetically-regulated serum GAS5 could serve as a potential biomarker in CHB patients. Loss of GAS5 is associated with DNMT1-mediated promoter methylation.
Near-Infrared Optical Spectroscopy In Vivo Distinguishes Subjects with Alzheimer’s Disease from Age-Matched Controls
Authors: Greco Frank A. , McKee Ann C. , Kowall Neil W. , Hanlon Eugene B.
Published: June 2021

Background: Medical imaging methods such as PET and MRI aid clinical assessment of Alzheimer’s disease (AD). Less expensive, less technically demanding, and more widely deployable technologies are needed to expand objective screening for diagnosis, treatment, and research. We previously reported brain tissue near-infrared optical spectroscopy (NIR) in vitro indicating the potential to meet this need. Objective: To determine whether completely non-invasive, clinical, NIR in vivo can distinguish AD patients from age-matched controls and to show the potential of NIR as a clinical screen and monitor of therapeutic efficacy. Methods: NIR spectra were acquired in vivo. Three groups were studied: autopsy-confirmed AD, control and mild cognitive impairment (MCI). A feature selection approach using the first derivative of the intensity normalized spectra was used to discover spectral regions that best distinguished “AD-alone” (i.e., without other significant neuropathology) from controls. The approach was then applied to other autopsy-confirmed AD cases and to clinically diagnosed MCI cases. Results: Two regions about 860 and 895 nm completely separate AD patients from controls and differentiate MCI subjects according to the degree of impairment. The 895 nm feature is more important in separating MCI subjects from controls (ratio-of-weights: 1.3); the 860 nm feature is more important for distinguishing MCI from AD (ratio-of-weights: 8.2). Conclusion: These results form a proof of the concept that near-infrared spectroscopy can detect and classify diseased and normal human brain in vivo. A clinical trial is needed to determine whether the two features can track disease progression and monitor potential therapeutic interventions.
Novel Rare SORL1 Variants in Early-Onset Dementia
Authors: Korpioja Anita , Krüger Johanna , Koivuluoma Susanna , Pylkäs Katri , Moilanen Virpi , Helisalmi Seppo , Hiltunen Mikko , Remes Anne M.
Published: June 2021

Background: Rare variants of SORL1 have been associated with an increased risk of early-onset or late-onset Alzheimer’s disease (AD). However, a lot remains to be clarified about their significance in the pathogenesis of the disease. Objective: To evaluate the role of SORL1 variants among Finnish patients with early-onset AD (EOAD). Methods: The rare SORL1variants were screened in a cohort of 115 Finnish EOAD patients (mean age at onset 58.3 years, range 46–65 years) by using the whole-exome sequencing. Results: We found one novel nonsense variant (p.Gln290*) and eight missense variants in SORL1. This is the first study reporting the SORL1 variants p.Lys80Arg, p.Ala789Val and p.Arg866Gln in EOAD patients. Furthermore, two of these three missense variants were overrepresented in EOAD patients compared to gnomAD non-neuro Finnish samples. Conclusion: This study strengthens the earlier findings, that the rare variants in SORL1 are associated with EOAD.