bluuebunny/crossref_metadata_2025 huggingface dataset:
Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation
Authors: Saroja Sivaprakasam R. , Gorbachev Kirill , Julia TCW , Goate Alison M. , Pereira Ana C.
Published: August 2022

Tau protein aggregates are a major driver of neurodegeneration and behavioral impairments in tauopathies, including in Alzheimer’s disease (AD). Apolipoprotein E4 (
APOE4
), the highest genetic risk factor for late-onset AD, has been shown to exacerbate tau hyperphosphorylation in mouse models. However, the exact mechanisms through which APOE4 induces tau hyperphosphorylation remains unknown. Here, we report that the astrocyte-secreted protein glypican-4 (GPC-4), which we identify as a binding partner of APOE4, drives tau hyperphosphorylation. We discovered that first, GPC-4 preferentially interacts with APOE4 in comparison to APOE2, considered to be a protective allele to AD, and second, that postmortem APOE4-carrying AD brains highly express GPC-4 in neurotoxic astrocytes. Furthermore, the astrocyte-secreted GPC-4 induced both tau accumulation and propagation in vitro. CRISPR/dCas9-mediated activation of GPC-4 in a tauopathy mouse model robustly induced tau hyperphosphorylation. In the absence of GPC4, APOE4-induced tau hyperphosphorylation was largely diminished using in vitro tau fluorescence resonance energy transfer-biosensor cells, in human-induced pluripotent stem cell-derived astrocytes and in an in vivo mouse model. We further show that APOE4-mediated surface trafficking of APOE receptor low-density lipoprotein receptor-related protein 1 through GPC-4 can be a gateway to tau spreading. Collectively, these data support that APOE4-induced tau hyperphosphorylation is directly mediated by GPC-4.
A specific JMJD6 inhibitor potently suppresses multiple types of cancers both in vitro and in vivo
Authors: Xiao Rong-quan , Ran Ting , Huang Qi-xuan , Hu Guo-sheng , Fan Da-meng , Yi Jia , Liu Wen
Published: August 2022

Jumonji C-domain-containing protein 6 (JMJD6), an iron (Fe2+) and α-ketoglutarate (α-KG)-dependent oxygenase, is expressed at high levels, correlated with poor prognosis, and considered as a therapeutic target in multiple cancer types. However, specific JMJD6 inhibitors that are potent in suppressing tumorigenesis have not been reported so far. We herein report that iJMJD6, a specific small-molecule inhibitor of JMJD6 with favorable physiochemical properties, inhibits the enzymatic activity of JMJD6 protein both in vitro and in cultured cells. iJMJD6 is effective in suppressing cell proliferation, migration, and invasion in multiple types of cancer cells in a JMJD6-dependent manner, while it exhibits minimal toxicity in normal cells. Mechanistically, iJMJD6 represses the expression of oncogenes, including Myc and CCND1, in accordance with JMJD6 function in promoting the transcription of these genes. iJMJD6 exhibits suitable pharmacokinetic properties and suppresses tumor growth in multiple cancer cell line– and patient-derived xenograft models safely. Furthermore, combination therapy with iJMJD6 and BET protein inhibitor (BETi) JQ1 or estrogen receptor antagonist fulvestrant exhibits synergistic effects in suppressing tumor growth. Taken together, we demonstrate that inhibition of JMJD6 enzymatic activity by using iJMJD6 is effective in suppressing oncogene expression and cancer development, providing a therapeutic avenue for treating cancers that are dependent on JMJD6 in the clinic.
Enhanced left superior parietal activation during successful speech production in patients with left dorsal striatal damage and error-prone neurotypical participants
Authors: Geva Sharon , Schneider Letitia M , Khan Shamima , Lorca-Puls Diego L , Gajardo-Vidal Andrea ,   PLORAS team, Anderson Storm , Bruce Rachel , Docksey Megan , Ledingham Kate , Lim Louise , Roberts Sophie , Hope Thomas M H , Green David W , Price Cathy J
Published: August 2022

Functional imaging studies of neurotypical adults report activation in the left putamen during speech production. The current study asked how stroke survivors with left putamen damage are able to produce correct spoken responses during a range of speech production tasks. Using functional magnetic resonance imaging, activation during correct speech production responses was assessed in 5 stroke patients with circumscribed left dorsal striatal lesions, 66 stroke patient controls who did not have focal left dorsal striatal lesions, and 54 neurotypical adults. As a group, patients with left dorsal striatal damage (our patients of interest) showed higher activation than neurotypical controls in the left superior parietal cortex during successful speech production. This effect was not specific to patients with left dorsal striatal lesions as we observed enhanced activation in the same region in some patient controls and also in more error-prone neurotypical participants. Our results strongly suggest that enhanced left superior parietal activation supports speech production in diverse challenging circumstances, including those caused by stroke damage. They add to a growing body of literature indicating how upregulation within undamaged parts of the neural systems already recruited by neurotypical adults contributes to recovery after stroke.
Predicting acupuncture efficacy for functional dyspepsia based on functional brain network features: a machine learning study
Authors: Yin Tao , He Zhaoxuan , Chen Yuan , Sun Ruirui , Yin Shuai , Lu Jin , Yang Yue , Liu Xiaoyan , Ma Peihong , Qu Yuzhu , Zhang Tingting , Suo Xueling , Lei Du , Gong Qiyong , Tang Yong , Liang Fanrong , Zeng Fang
Published: August 2022

Acupuncture is effective in treating functional dyspepsia (FD), while its efficacy varies significantly from different patients. Predicting the responsiveness of different patients to acupuncture treatment based on the objective biomarkers would assist physicians to identify the candidates for acupuncture therapy. One hundred FD patients were enrolled, and their clinical characteristics and functional brain MRI data were collected before and after treatment. Taking the pre-treatment functional brain network as features, we constructed the support vector machine models to predict the responsiveness of FD patients to acupuncture treatment. These features contributing critically to the accurate prediction were identified, and the longitudinal analyses of these features were performed on acupuncture responders and non-responders. Results demonstrated that prediction models achieved an accuracy of 0.76 ± 0.03 in predicting acupuncture responders and non-responders, and a R2 of 0.24 ± 0.02 in predicting dyspeptic symptoms relief. Thirty-eight functional brain network features associated with the orbitofrontal cortex, caudate, hippocampus, and anterior insula were identified as the critical predictive features. Changes in these predictive features were more pronounced in responders than in non-responders. In conclusion, this study provided a promising approach to predicting acupuncture efficacy for FD patients and is expected to facilitate the optimization of personalized acupuncture treatment plans for FD.
Sedimentary Processes and Depositional Characteristics of Coarse‐grained Subaqueous Fans along Steep Slopes in a Lacustrine Rift Basin: A Case Study from the Dongying Depression, Bohai Bay Basin, China
Authors: YANG Baoliang , QIU Longwei , YANG Yongqiang , KRA Kouassi Louis , DONG Daotao , KHAN Danish
Published: August 2022

Coarse‐grained subaqueous fans are vital oil and gas exploration targets in the Bohai Bay basin, China. The insufficient understanding of their sedimentary processes, depositional patterns, and controlling factors restricts efficient exploration and development. Coarse‐grained subaqueous fans in the Yong'an area, Dongying Depression, are investigated in this study. These fans include nearshore subaqueous fans, and sublacustrine fans, and their sedimentary processes, depositional patterns and distribution characteristics are mainly controlled by tectonic activity and paleogeomorphology. Nearshore subaqueous fans developed near the boundary fault during the early–middle deposition stage due to strong tectonic activity and large topographic subsidence. Early sublacustrine fans developed at the front of the nearshore subaqueous fans in the area where the topography changed from gentle to steep along the source direction. While the topography was gentle, sublacustrine fans did not develop. During the late weak tectonic activity stage, late sublacustrine fans developed with multiple stages superimposed. Frequent fault activity and related earthquakes steepened the basin margin, and the boundary fault slopes were 25.9°–34°. During the early–middle deposition stage, hyperpycnal flows triggered by outburst floods developed. During the late deposition stage, with weak tectonic activity, seasonal floods triggered hyperpycnal flows, and hybrid event beds developed distally.
Effect of introduction of routine single shot adductor canal block in primary total knee arthroplasty in a rural Australian setting
Authors: Otieno James , Ng Rachel , Graffen Simon , Diebold Robin
Published: August 2022

Background

There is a growing demand for quality osteoarthritis management available in Australia. There has been increasing emphasis on post‐total knee replacement pain relief as a significant issue, especially in the context of postoperative recovery protocols which focus on early mobility.

Methods

The aim of this study was to assess if the addition of adductor canal blocks (ACB) reduced postoperative pain and affected mobility post primary total knee arthroplasty (TKR) at Armidale Rural Referral Hospital (ARRH). A retrospective cohort study was performed of unilateral TKR patients before and after the addition of adductor canal blocks to the TKR protocol at ARRH. Forty‐seven patients were included in the study who are matched for age and radiographic disease severity. All patients were prescribed post‐operative analgesia per the protocol.

Results

Patients who received an ACB had a significant difference in opioid consumption in the first 24 h post‐operative compared with those who did not, 115.90 mg oral morphine compared to 66.07 mg (P = 0.0001). This was also supported by a significant difference in patient self‐rated numerical pain score between groups, no ACB group 3.09/10 and ACB group 1.05/10 (P = 0.0001). The ACB group were able to mobilize further on post‐op days 1 and 2 than those who did not receive an ACB with the ACB group (P = 0.0001 and 0.0008).

Conclusion

This adds to the evidence supporting the use of Adductor Canal Blocks in patients undergoing total knee arthroplasty, of especial significance in a rural population.
ICAM1 promotes bone metastasis via integrin‐mediated TGF‐β/EMT signaling in triple‐negative breast cancer
Authors: Chen Mingcang , Wu Chunyu , Fu Zhengwei , Liu Sheng
Published: August 2022

Bone‐related events caused by breast cancer bone metastasis substantially compromise the survival and quality of life of patients. Because triple‐negative breast cancer (TNBC) lacks hormone receptors and Her2‐targeted therapeutic options, progress in the treatment of TNBC bone metastasis has been very slow. Intercellular adhesion molecule 1 (ICAM1) is highly expressed in various cancers and plays an important role in tumorigenesis and metastasis. However, the effect and mechanism of ICAM1 in TNBC bone metastasis are still unknown. We found that ICAM1 was highly expressed in TNBC and correlated with prognosis in TNBC patients. Cell lines with high expression of ICAM1 exhibited enhanced bone metastasis in tumor‐bearing mice, and silencing ICAM1 expression significantly inhibited bone metastasis in mice. ICAM1 interacted with integrins to activate the epithelial‐to‐mesenchymal transition program through TGF‐β/SMAD signaling, ultimately enhancing cell invasiveness. Therefore, the findings of the present study provide a strong rationale for the application of ICAM1‐targeted therapy in TNBC patients with bone metastasis.
Anti‐disialosyl‐immunoglobulin M chronic autoimmune neuropathies: a nationwide multicenter retrospective study
Authors: Peillet Claire , Adams David , Attarian Shahram , Bouhour Françoise , Cauquil Cécile , Cassereau Julien , Chanson Jean‐Baptiste , Cintas Pascal , Creange Alain , Delmont Emilien , Fargeot Guillaume , Genestet Steeve , Gueguen Antoine , Kaminsky Anne Laure , Kuntzer Thierry , Labeyrie Céline , Michaud Maud , Pereon Yann , Puma Angela , Viala Karine , Chretien Pascale , Adam Clovis , Echaniz‐Laguna Andoni
Published: August 2022

Background and purpose

In this retrospective study involving 14 university hospitals from France and Switzerland, the aim was to define the clinicopathological features of chronic neuropathies with anti‐disialosyl ganglioside immunoglobulin M (IgM) antibodies (CNDA).

Results

Fifty‐five patients with a polyneuropathy evolving for more than 2 months and with at least one anti‐disialosyl ganglioside IgM antibody, that is, anti‐GD1b, ‐GT1b, ‐GQ1b, ‐GT1a, ‐GD2 and ‐GD3, were identified. Seventy‐eight percent of patients were male, mean age at disease onset was 55 years (30–76) and disease onset was progressive (82%) or acute (18%). Patients presented with limb sensory symptoms (94% of cases), sensory ataxia (85%), oculomotor weakness (36%), limb motor symptoms (31%) and bulbar muscle weakness (18%). Sixty‐five percent of patients had a demyelinating polyradiculoneuropathy electrodiagnostic profile and 24% a sensory neuronopathy profile. Anti‐GD1b antibodies were found in 78% of cases, whilst other anti‐disialosyl antibodies were each observed in less than 51% of patients. Other features included nerve biopsy demyelination (100% of cases), increased cerebrospinal fluid protein content (75%), IgM paraprotein (50%) and malignant hemopathy (8%). Eighty‐six percent of CNDA patients were intravenous immunoglobulins‐responsive, and rituximab was successfully used as second‐line treatment in 50% of cases. Fifteen percent of patients had mild symptoms and were not treated. CNDA course was progressive (55%) or relapsing (45%), and 93% of patients still walked after a mean disease duration of 11 years.

Conclusion

Chronic neuropathies with anti‐disialosyl ganglioside IgM antibodies have a recognizable phenotype, are mostly intravenous immunoglobulins‐responsive and present with a good outcome in a majority of cases.
Cross-cultural Adaptation and Validity of the Patient Rated Michigan Hand Outcome Questionnaire in Bahasa Melayu for Malaysian Patients
Authors: KUMAR Abilash , HARUN Hezery , HAKIM Ashraf , GANAPATHY Shubash S. , M Arumugam
Published: August 2022

Background: The Michigan Hand Outcomes Questionnaire (MHQ) was designed in 1998 by Chung and colleagues at the University of Michigan in 1998. It is a hand-specific patient-rated outcome (PRO) instrument used to measure patients’ outcome with conditions of, or injury to, the hand and/or wrist. This study is aimed at translating and cross-culturally adapting the MHQ into Bahasa Melayu (BM), examining the validity and reliability of the MHQ-BM version for our local population to be used as a patient-rated outcome measurement in Malaysian patients with hand injuries.

Methods: This study was performed in two phases. Phase 1 involved the translation of the MHQ into BM using Beaton Protocol. In Phase 2, we administered the final version of the MHQ–BM in patients with hand and/or wrist injuries to test its stability (n = 50) and validity (n = 185).

Results: The MHQ–BM showed good content and face validity. Cronbach α totalled 0.821 for the MHQ–BM. The Intra-class Correlation Coefficient (ICC) of the test–retest reliability for the six domains ranged from 0.960 to 0.984 with excellent correlation (ICC = 0.984) for the total score. The BM version of MHQ–BM showed excellent test–retest reliability.

Conclusions: The MHQ–BM is well-translated and culturally well-adapted to maintain the reliability and content validity of the instrument (MHQ) at a conceptual level across Malaysia. We found the application and evaluation of the instrument to be feasible and understandable among patients with hand and/or wrist injuries in Malaysia.
Reliability of Extensor Pollicis Brevis (EPB) Entrapment Test in Identifying a Separate Compartment for EPB in Patients with de Quervain Disease
Authors: SRAVANI Muddada , REDDY Satyanarayana , BHARDWAJ Praveen , VARADHARAJAN Vigneswaran , SABAPATHY S. Raja
Published: August 2022

Background: The presence of a separate compartment for the extensor pollicis brevis tendon (EPB) has an implication in the treatment outcome for de Quervain disease. The EPB entrapment test, proposed by Alexander and colleagues, claims to correlate with the presence of a separate compartment for EPB. The purpose of our study is to evaluate the reliability of the EPB entrapment test in predicting a separate compartment for EPB in patients with de Quervain disease.

Methods: This was a prospective observational study involving 50 consecutive patients who underwent de Quervain release by a single surgeon. Preoperatively, EPB entrapment test was performed by the operating surgeon. The outcome of the test was recorded and the presence of a separate compartment for the EPB was determined during surgery. Sensitivity, specificity, positive predictive value and negative predictive value of the EPB entrapment test was determined.

Results: EPB entrapment test was positive in 28 of 50 patients. In 21 of them, a separate compartment for the EPB was noted. The positive predictive value of the test was found to be 75.8%. The test had a false positive rate of 26.9%, a false negative rate of 12.5%, sensitivity of 87.5% and specificity of 73%. There is a significant association between a positive EPB entrapment test and the presence of a separate compartment for the EPB (p value <0.001). The sensitivity of the test increases to 95.8% if pain on both extension and abduction of the thumb is considered a positive response.

Conclusions: The EPB entrapment test is a reliable clinical test to look for the presence of a separate compartment for EPB. Considering the response of pain on both extension and abduction of the thumb further improves the sensitivity of the test. Hence, we suggest including this response also as a positive test.

Level of Evidence: Level II (Diagnostic)
A Comparison of the Outcomes of Fiber-Wire® versus Stainless Steel Wire in Transosseous Wiring for Intra-Articular Fractures of the Distal Interphalangeal Joint
Authors: ISHIBASHI Shigeki , HACHISUKA Hiroki , SHIMOSE Shoji , ADACHI Nobuo
Published: August 2022

Background: Different surgical techniques have been described for the treatment of intra-articular fractures involving extensor tendon insertion of the distal interphalangeal joint (DIPJ), including acute and chronic bony mallet injuries. We have been using transosseous stainless-steel wire (SSW) in select patients. In 2015, we started using a non-absorbable polyester suture (2-0 Fiber-Wire®, Arthrex, Naples, FL, USA) instead of SSWs. The aim of this study is to compare the outcomes of SSW and Fiber-Wire® (FBW) in transosseous wiring for intra-articular fractures of the DIPJ.

Methods: This is a retrospective review of patients who underwent fixation of intra-articular fractures, including extensor tendon insertion of the DIPJ using a transosseous wiring technique, in the period from 2013 to 2018. SSW was used in the period from 2013 to 2014, and FBW was used from 2015 to 2018. Outcomes with regard to age, gender, time to union, range of motion at the DIPJ and complications were recorded and compared between the SSW and FBW groups.

Results: Nine patients (mean age: 38 years) underwent fixation with SSW and 10 patients (mean age: 31 years) with FBW. The operative time was significantly lower in the FBW group, and all the fractures united. There were no statistically significant differences between both groups with regard to time to union or range of motion at the DIPJ. Similar complication rates were observed in both groups.

Conclusions: The use of FBW in transosseous wiring for intra-articular fractures of the DIPJ can reduce operative time and provide functional results similar to that of SSWs. It can be considered as an alternative fixation technique for difficult intra-articular comminuted fractures of the DIPJ, including acute and chronic bony mallet injuries with joint subluxation.

Level of Evidence: Level III (Therapeutic)
Chronic Recurrent Multifocal Osteomyelitis in a Child’s Hand: Case Report and Review
Authors: HARDER Noemi , WOERNER Andreas , KAEMPFEN Alexandre , MENDE Konrad
Published: August 2022

We present a 9-year-old girl with persistent pain and swelling of the left wrist. X-ray, magnetic resonance imaging (MRI) and bone biopsy led to the diagnosis of chronic recurrent multifocal osteomyelitis (CRMO), affecting phalangeal and metacarpal bases and distal carpal bones on the ulnar side of the wrist. She was treated with non-steroidal anti-inflammatory drugs and complete remission with no long-term sequelae was achieved. CRMO is a rare auto-inflammatory condition with infrequent involvement of the hand. The current literature is discussed. The aim of this report is to raise awareness of the condition to reduce the time to diagnosis and unnecessary antibiotic treatment and to prevent permanent disability due to the progression of the disease.

Level of Evidence: Level V (Therapeutic)
Impedance Response of Ionic Liquids in Long Slit Pores
Authors: Tomlin Ruben J. , Roy Tribeni , Kirk Toby L. , Marinescu Monica , Gillespie Dirk
Published: August 2022

We study the dynamics of ionic liquids in a thin slit pore geometry. Beginning with the classical and dynamic density functional theories for systems of charged hard spheres, an asymptotic procedure leads to a simplified model which incorporates both the accurate resolution of the ion layering (perpendicular to the slit pore wall) and the ion transport in the pore length. This reduced-order model enables qualitative comparisons between different ionic liquids and electrode pore sizes at low numerical expense. We derive semi-analytical expressions for the impedance response of the reduced-order model involving numerically computable sensitivities, and obtain effective finite-space Warburg elements valid in the high and low frequency limits. Additionally, we perform time-dependent numerical simulations to recover the impedance response as a validation step. We investigate the dependence of the impedance response on system parameters and the choice of density functional theory used. The inclusion of electrostatic effects beyond mean-field qualitatively changes the dependence of the characteristic response time on the pore width. We observe peaks in the response time as a function of pore width, with height and location depending on the potential difference imposed. We discuss how the calculated dynamic properties can be used together with equilibrium results to optimise ionic liquid supercapacitors for a given application.
Memória e Antologia poética, por Fernanda Correia Dias
Authors: Dias Fernanda Correia
Published: August 2022

Coletânea de textos realizada por Fernanda Correia Dias.
A influência de fatores psicossociais protetores sobre a incidência de dor dentária
Authors: Alvarenga Mariana Guimarães Jorge de , Rebelo Maria Augusta Bessa , Lamarca Gabriela de Almeida , Paula Janice Simpson de , Vettore Mario Vianna
Published: August 2022

OBJETIVO Investigar a influência de fatores psicossociais protetores sobre a incidência de dor dentária nos últimos seis meses em crianças de 12 anos residentes em Manaus (AM). MÉTODOS Um estudo de coorte prospectivo de base escolar foi realizado com 210 alunos de 12 anos, matriculados em escolas públicas da zona leste de Manaus (AM) que foram acompanhados por dois anos. Questionários validados foram usados para avaliar características sociodemográficas, fatores psicossociais protetores, incluindo senso de coerência, apoio social e autoestima na linha de base e após dois anos. Examinadores calibrados avaliaram clinicamente cárie dentária e sangramento gengival. Regressão de Poisson multinível multivariada foi usada para estimar o risco relativo (RR) e o intervalo de confiança de 95% (IC95%) entre a variação dos escores dos fatores psicossociais e a incidência de dor dentária, ajustada para os escores dos fatores psicossociais na linha de base, plano de saúde odontológico, frequência de escovação dentária e cárie dentária. RESULTADOS As médias dos escores do senso de coerência e do apoio social reduziram significativamente entre linha de base e seguimento de dois anos. A incidência de dor dentária no seguimento de dois anos foi 28,6%. O risco de dor dentária foi 14% maior para cada 10 pontos na redução média do escore do senso de coerência (RR = 1,14; IC95% 1,02–1,20), e 6% maior para cada 10 pontos na redução média do escore do apoio social (RR = 1,06; IC95% 1,01–1,11). A mudança na autoestima não foi associada ao risco de dor dentária. CONCLUSÃO A variação do senso de coerência e do apoio social no período de dois anos influenciou a incidência de dor dentária em crianças, sugerindo que fatores psicossociais protetores, comportamentos em saúde, plano odontológico e a condição clínica bucal desempenham um papel importante na incidência da dor dentária.
O porão do navio negreiro como digênese nos romances Um defeito de cor e O crime do cais do Valongo
Authors: Bispo Ella Ferreira , Carvalho Jéssica Catharine Barbosa de , Alves Alcione Corrêa
Published: August 2022

Este artigo visa discutir algumas condições a uma identidade tributária das culturas compósitas nas Américas, a partir da leitura de Um defeito de cor de Ana Maria Gonçalves (2009) e O crime do cais do Valongo de Eliana Alves Cruz (2018). Organizamos nossos procedimentos de diálogo entre os romances mencionados tomando o navio negreiro como um lugar-comum (GLISSANT, 2005). Nossa argumentação parte da hipótese de que a expressão de uma enunciação desde o porão do navio negreiro nos romances em análise nos habilita a lê-los enquanto digêneses (GLISSANT; 2014, 1997).
Acrocalymma guizhouense sp. nov. (Acrocalymmaceae, Dothideomycetes) from soil in China
Authors: SHAO QIU-YU , QI YING-HUA , WANG JING , YANG YAN-MING , ZHANG ZHI-YUAN , CHEN WAN-HAO , LIANG JIAN-DONG , LIANG ZONG-QI , HAN YAN-FENG
Published: August 2022

A new species of Acrocalymma, A. guizhouense, isolated from the rhizosphere soil of Perilla frutescens, is introduced. Morphological characteristics, culture characteristics on PDA, OA, MEA, and phylogenetic analyses based on multi-locus datasets (SSU + LSU + ITS) support the establishment of the new species. Morphologically, A. guizhouense is distinguished from other species of Acrocalymma in having narrow conidia with a width of 1.5-2.5 µm. Phylogenetically, A. guizhouense formed a separated subclade with well-supported (100 MLBS/1.00 BYPP) value, which confirmed the taxonomic placement in the genus Acrocalymma.
Evaluation of a novel optical smartphone blood pressure application: a method comparison study against invasive arterial blood pressure monitoring in intensive care unit patients
Authors: Desebbe Olivier , Anas Chbabou , Alexander Brenton , Kouz Karim , Knebel Jean-Francois , Schoettker Patrick , Creteur Jacques , Vincent Jean-Louis , Joosten Alexandre
Published: August 2022

Background

Arterial hypertension is a worldwide public health problem. While it is currently diagnosed and monitored non-invasively using the oscillometric method, having the ability to measure blood pressure (BP) using a smartphone application could provide more widespread access to hypertension screening and monitoring. In this observational study in intensive care unit patients, we compared blood pressure values obtained using a new optical smartphone application (OptiBP™; test method) with arterial BP values obtained using a radial artery catheter (reference method) in order to help validate the technology.

Methods

We simultaneously measured three BP values every hour for five consecutive hours on two consecutive days using both the smartphone and arterial methods. Bland–Altman and error grid analyses were used for agreement analysis between both approaches. The performance of the smartphone application was investigated using the Association for the Advancement of Medical Instrumentation (AAMI) and the International Organization for Standardization (ISO) definitions, which require the bias ± SD between two technologies to be below 5 ± 8 mmHg.

Results

Among the 30 recruited patients, 22 patients had adequate OptiBP™ values and were thus analyzed. In the other 8 patients, no BP could be measured due to inadequate signals. The Bland–Altman analysis revealed a mean of the differences ± SD between both methods of 0.9 ± 7 mmHg for mean arterial pressure (MAP), 0.2 ± 14 mmHg for systolic arterial pressure (SAP), and 1.1 ± 6 mmHg for diastolic arterial pressure (DAP). Error grid analysis demonstrated that the proportions of measurement pairs in risk zones A to E were 88.8% (no risk), 10% (low risk), 1% (moderate risk), 0% (significant risk), and 0% (dangerous risk) for MAP and 88.4%, 8.6%, 3%, 0%, 0%, respectively, for SAP.

Conclusions

This method comparison study revealed good agreement between BP values obtained using the OptiBP™ and those done invasively. The OptiBP™ fulfills the AAMI/ISO universal standards for MAP and DAP (but not SAP). Error grid showed that the most measurements (≥ 97%) were in risk zones A and B.

Trial registration

ClinicalTrials.gov registration: NCT04728477
Proactive Regime for the Public Services in the Labour Market: Areas of Improvement
Authors: Dyudikova Ekaterina , Kunitsyna Natalia
Published: August 2022

Restrictive measures of the pandemic period accelerated the digitalization process, stimulating a forced transition to an all-encompassing remote format of interaction between economic actors. As a result, the problems and the shortcomings demonstrated the inability of classical technological solutions to become the basis of the digital state. The article proved that the exceptional interaction in the information and communication environment, based on disparate autonomous electronic systems, not only did not satisfy the needs of modern society, but also contributed to the growth of offenses and damage to the economy. The conclusion was drown about the inability of the electronic environment of remote interaction to ensure the effective and high-quality implementation of the proactive regime for the state and municipal services, which has been actively introduced since 2021. Thus, during the pandemic period, the labour market became the most vulnerable, first of all requiring the effective and expeditious mediation role of state structures in order to ensure its sustainability. The study revealed the main problems of the remote format of interaction between entities under the conditions of the modern financial system architecture and the traditional way of organizing information processes. By comparing classical and innovative approaches to the organization of a proactive system for the state and municipal services the authors proposed the directions for its improvement taking into account the interests of the state and citizens.
Exploring healthcare providers’ experiences with specialty medication and limited distribution networks
Authors: Peter Megan E. , Zuckerman Autumn D. , Cherry Elizabeth , Schlundt David G. , Bonnet Kemberlee , Shah Nisha , Kelley Tara N.
Published: August 2022

Integrated health-system specialty pharmacies (IHSSP) have shown high medication access, adherence, and provider satisfaction. The goal of this study was to explore healthcare providers’ experiences with specialty medications distributed via Limited Distribution Networks (LDN) that do not include IHSSPs. We investigated healthcare providers’ perceived impact of LDNs on clinic workflow, clinical practice, and patient outcomes. Interviews and focus groups were conducted with fourteen healthcare providers from four outpatient specialty clinics at an academic health system with an IHSSP. Qualitative analysis using an iterative inductive/deductive approach of coded transcripts was used to identify themes. Participants discussed requirements and barriers to communicating with insurance providers, drug manufacturers, and external pharmacies; time and effort required to navigate LDNs and impact on workload and clinic workflow; financial awareness of medication costs and methods for communication about financial information with patients; and advocating for patients to ensure access to necessary therapy and avoid missed doses or treatment lapse. Participants reported barriers to navigating LDNs that can interfere with clinic workflow and patient care. IHSSPs may reduce clinic burden by helping patients access, afford, and remain on therapy.
Repetition compulsion as primum movens of religion? On Christoph Türcke’s Philosophy of Dreams
Authors: Hösle Vittorio
Published: August 2022

The essay exposes, recognizes the astonishing originality, and showcases the shortcomings of Christoph Türcke’s Philosophy of Dreams, which offers a theory of the origin of religion inspired by both psychoanalysis and critical theory. Among the objections raised are the speculative nature of the enterprise, which is not sufficiently based on empirical data, the lack of knowledge concerning the transition from apes to humans, the impossibility for hallucinations to be the basic doxastic act, the exaggerated focus on dread, which is only one form of the numinous experience, and on the repetition compulsion, which could hardly prove as creative as the author assumes particularly concerning the origin of sacrifice, and the confusion of genesis and validity.
Kein primum movens. Replik
Authors: Türcke Christoph
Published: August 2022

Der traumatische Wiederholungszwang ist kein primum movens, sondern eine reaktive dialektische Bewegung. Sie hat zwar die Menschheitsgeschichte eröffnet; aber deren Verlauf lässt sich aus ihr nicht deduzieren. Hösles Verdacht, dass meine Philosophie des Traums genau dies versucht, entspringt seiner Neigung, meine dialektische Konzeption dualistisch zu lesen. Während mir eine Fundierung negativer Dialektik von der Psychoanalyse aus vorschwebt, bleibt er bei der positiven Dialektik des objektiven Idealismus. Daraus ergeben sich auch unterschiedliche Vorstellungen über die Leistungsfähigkeit der Mentalarchäologie, die ich betreibe.
Watching and feeling ballet: neuroscience and semiotics of bodily movement
Authors: Kruk Sergei
Published: August 2022

Neuroscience has established several brain pathways that process visual information. Distinct neural circuits analyze body appearance and movement providing information about the person’s cognitive and emotional states. The activity of the pathways depends on the salience of visual stimuli for the organism in the given circumstances. Since ballet performances are not among the crucial events for the viewer’s organism, not all viewers perceive and interpret bodily signs that express the mental state of the dancer. Treatment of the dancer as close other activates the neural circuits that elaborate emotions, this enables the viewer to feel the internal state of the dancer and enrich the interpretation of the scenic action.
The new basketball body: an analysis of corporeity in modern NBA basketball
Authors: Tamayo Yair
Published: August 2022

The average weight and height of National Basketball League (NBA) players is decreasing year by year (Brady, Benedict. 2017. Maybe we should call it skinny-ball: Weight vs. height in the NBA. Harvard Sports Analysis Collective. http://harvardsportsanalysis.org/2017/11/maybe-we-should-call-it-skinnyball-weight-vs-height-in-the-nba/ (accessed 30 September 2021); Curcic, Dimitrije. 2021. 70 years of height evolution in the NBA [4,504 players analyzed]. RunRepeat. https://runrepeat.com/height-evolution-in-the-nba (accessed 30 September 2021)). The trend in basketball is to privilege the tallest and strongest. If so, then to what does the body modification of NBA players respond? Will these changes reformulate the corporeity of what is understood as an NBA player? This text seeks, from the postulates of Jacques Fontanille (2008 [2004]. Soma y sema: Figuras semióticas del cuerpo [Soma and sema: Semiotic figures of the body]. Peru: Fondo Editorial Universitario de Lima) and José Finol (2015. The corposphere: Anthropo-semiotics of the cartographies of the body [La corposfera: antropo-semiótica de las cartografías del cuerpo]. Ecuador: CIESPAL), to point out that the process of body modification arose both from the introduction of a new rule (three-point shot) and the recognition to new corporealities. From data regarding players’ corporeality, shooting tendency and a body modification scheme, a new corporeality of the NBA player is proposed, one that is no longer determined entirely by height.
Religious philosophy of Thomas Chubb
Authors: Polyakov Andrey
Published: August 2022

The article presents a brief biography of the little-studied British deist Thomas Chubb (1679-1747) and a reconstruction of his ideas about capabilities of human mind. The goal of this article is to study the religious philosophy of T. Chubb that Russian studies does not distinguish from ideas of other deists. That is why the idea of the phenomenon of deism is still less clear in relation to foreign studies. The article analyzes and presents Chubbs concepts about the independence of religious truths from human perception, that are presented in «Discourse concerning Reason, with Regard to Religion and Divine Revelation» (1733) and «An Enquiry into the Ground and Foundation of Religion». The article documents that the English philosopher formulated three "author's" truths of natural religion: there is an initial difference between objects, independent of human perception; this distinction is the basis for human behavior; God made these foundations a moral rule for all people and for himself. The work identifies and analyzes the definition of the phenomenon of "deism" in Chubb's treatises, as well as an assessment of his philosophy in the context of this definition – the natural religion of reason or belief and just and sense of a Deity impressed upon the mind, and is the governing principle of a man’s-affections and actions. The correlation of the ideas of Thomas Chubb and Matthew Tindal is analyzed. At the end of the article, a brief conclusion is made about the place of T. Chubbs philosophy to deism in general. The author of this work believes that despite the absence of references to other deists by the English philosopher, the ideas of this thinker fit into their religious and philosophical system, specifically about the issue of understanding natural religion. The sources of this article are treaties «The Sufficiency of Reason in Matters of Religion, Farther Considered» (1732), «Discourse concerning Reason, with Regard to Religion and Divine Revelation» (1733), «Some reflections upon the comparative excellency and usefulness of moral and positive duties» (1733), «The true Gospel of Jesus Christ Asserted»(1741) and several other treatises.
Comprometimentos motores e a Evolução da Doença de Parkinson
Authors: De Oliveira Cruz Ana Paula , Ribeiro Rachel Trinchão Schneiberg Kalid , Santos Dayana Da Silva
Published: August 2022

Introdução: A Doença de Parkinson (DP) caracteriza- se como uma doença neurodegenerativa, progressiva e multissitêmica causada pela morte dos neurônios dopaminérgicos da parte compacta da substância negra, que pode levar seus indivíduos a manifestar diversos sintomas motores durante a evolução da doença. Objetivo: Identificar, segundo a literatura, os comprometimentos motores da DP e associar com a evolução da doença. Materiais e Métodos: Trata-se de uma Revisão Sistemática, realizada no período entre dezembro de 2020 e maio de 2021, nas bases de dados PubMed, ScieLo, PEDro e LILACs. Foram incluídos estudos do tipo ensaio clínico randomizado, nos idiomas inglês e português, sem restrição de ano, realizados em humanos, que abordassem os comprometimentos motores em indivíduos diagnosticados com DP. Resultados: Foram identificados um total de 550 artigos, dos quais 545 foram eliminados, resultando no final a inclusão de 5 estudos publicados entre 2009 a 2014. Conclusão: Foram encontrados os comprometimentos motores mais clássicos da DP, contudo durante seu avanço é possível detectar outros sintomas motores que podem ter uma relevância diante o estadiamento da doença.
Prevalência de excesso de peso e associação com níveis pressóricos em trabalhadores do pólo moveleiro de Ubá-MG
Authors: Oliveira Pedro Victor Santos Rodrigues de , Oliveira Renata Aparecida Rodrigues de , Baião Braúlio Parma , Marins João Carlos Bouzas
Published: August 2022

Introdução: As doenças cardiovasculares (DCV) é uma das maiores causas de óbito do mundo, com uma elevada taxa também no Brasil. Dentre os fatores de risco cardiovasculares, tem-se o excesso de peso que apresenta causas muito complexas e multifatorial. Objetivo: Determinar a prevalência de excesso de peso e associação com níveis pressóricos em trabalhadores do pólo moveleiro de Ubá-MG. Métodos: A amostra foi composta por 220 trabalhadores do pólo moveleiro, de ambos os sexos, sendo 43 mulheres (33,02+7,05 anos) e 177 homens (35,85+10,78 anos). Foram aferidas as medidas de estatura e massa corporal para calcular o índice de massa corporal (IMC); circunferências da cintura (CC), abdômen (CA) e quadril para o cálculo da relação cintura quadril (RCQ); e também foram verificadas as dobras cutâneas para calcular o percentual de gordura (%GC). Foi obtido os valores de pressão arterial sistólica (PAS) e diastólica (PAD), após cinco minutos em repouso. Resultados: Pelo critério de IMC foi encontrado 37,29% de sobrepeso e 19,77% de obesidade nos homens; e 30,23% de sobrepeso e 30,23% de obesidade nas mulheres. Os indivíduos com excesso de peso (IMC 25 kg/m²), apresentaram maiores valores antropométricos (CC, CA, RCQ e %GC) e pressóricos (p0,05). Em relação a obesidade abdominal, 19,5% dos professores estavam com a CA “alta” e 21,8% “muito alta”. O IMC apresentou correlação regular com a PAS (rs=0,546; p0,001) e PAD (rs=0,512; p0,001). Conclusões: Foi obtido elevada prevalência de excesso de peso entre os trabalhadores, sendo que estes se correlacionaram com os níveis pressóricos.
Identificação e Validação da Nomenclatura dos Fundamentos Técnicos do Beach Tennis
Authors: Martins Leonardo Da Silva , Ravagnani Christianne De Faria Coelho , Ravagnani Fabricio
Published: August 2022

No Beach Tennis, como em outras modalidades, existem ações técnicas utilizadas pelos praticantes, que são chamadas de fundamentos. Estes fundamentos, possuem uma técnica conhecida por professores, alunos, técnicos e atletas, entretanto, nem todos os fundamentos são chamados pelo mesmo nome e outros ainda não possuem um nome.  O presente estudo teve como objetivo identificar, nominar e validar os fundamentos do Beach Tennis (BT) com os especialistas, coaches e atletas. Este estudo utilizou a técnica Delphi Modificada. O painel de especialista foi composto por 120 coaches/atletas de BT, de ambos os sexos, das categorias A e Pró (profissional). Para a Identificação dos fundamentos realizamos uma pesquisa bibliográfica e observamos jogos amadores e profissionais. Fizemos uma sugestão de nomes aos fundamentos observados que não estavam na literatura e criamos subcategorias aos outros fundamentos já descritos. Para coleta dos dados, construímos um instrumento na plataforma do Google, utilizando a ferramenta Google Forms. Para a validação utilizamos a Técnica Delphi Modificada. Encontramos na literatura, e observando jogos amadores e profissionais, 49 fundamentos que são utilizados no BT, os quais foram enviados ao painel de especialistas e solicitado que concordassem ou discordassem do nome proposto para os mesmos. Todos os fundamentos propostos atingiram um índice superior a 75% de concordância.  O consenso final resultou na identificação e nominação de 15 novos fundamentos e 12 novas variações de fundamentos. Além disso, 17 fundamentos já descritos na literatura receberam nomenclatura nova e 5 fundamentos mantiveram o mesmo nome. Este estudo contribui de forma significativa no crescimento da modalidade, pois permite que o BT possua uma nomenclatura de fundamentos própria e validada, permitindo que pesquisadores, atletas, professores, técnicos, jornalistas e telespectadores, possam se referir aos fundamentos na produção de conhecimento em artigos e livros, em transmissões televisivas, nos treinamentos e aulas ou em outras discussões pertinentes à modalidade.
Anger control is the most influential risk factor of mobile phone addiction among nursing and midwifery students of Zahedan University of Medical Sciences
Authors: Dehghanmehr Sadegh , KordSalarzehi Fatemeh , Ghiamikeshtgar Najmeh , Mir Nahid , Heravan Mahsima Banaei , Shafeie Farhad
Published: August 2022

BackgroundReligious attitude and anger management are two psychopathological constructs receiving little empirical scrutiny in relation to smart phone addiction, but theoretically should demonstrate significant relationships. Today one of these new media that is used by many people around the world, is the mobile phone. Students are one of the most important groups that are affected by mobile social networks. The aim of this study was to determine religious attitudes and anger management as risk factors of mobile phone addiction in nursing and midwifery students.
MethodsThis study was a cross-sectional study involving 200 nursing and midwifery students. Relevant data were collected through demographic information questionnaire, anger management skills questionnaire, religious attitude questionnaire, and mobile phone addiction questionnaire. A multiple regression model was used to examine the relationship between variables.
ResultsThe mean age of the research subjects was 22.04 ± 3.30 years. Anger control and religious attitude were a significant risk factors of smartphone addiction (β=-0.500; p=0.000; β= -0.069; p=0.004, respectively). The variables of anger ýcontrol and spiritual attitude can predict and explain 33.6% and 2.7% (36.3% in total) of the ýchanges in the mobile addiction score. Anger control is the most influential risk factor of mobile phone addiction among nursing and midwifery students (Beta = -0.385).
ConclusionFindings indicate the importance of controlling anger and strengthening religious attitude in reducing the rate of mobile phone addiction in students. This provides guidance to the future development of smartphone addiction prevention programs for students.
The Value of Fibrinogen/Albumin Ratio on Prognosis of COVID-19 Patients
Authors: ÇİÇEKLİ Esen , SAYAN Saadet , SARICA  DAROL Elif , KOTAN Dilcan
Published: August 2022

Aim: Fibrinogen and albumin are proteins that play a role in inflammation. In this study, it was aimed to investigate the role of fibrinogen, albumin, and fibrinogen/albumin ratio (FAR) levels as markers of disease severity and prognosis in coronavirus disease 2019 (COVID-19) patients.
Material and Methods: Seventy-one patients aged between 19 and 84 years diagnosed with COVID-19 who were hospitalized in Sakarya University Training and Research Hospital, Neurology Department between March and May 2020 were analyzed retrospectively. Fibrinogen, albumin, FAR, D-dimer, platelet, and C-reactive protein (CRP) levels of the patients were compared according to the length of hospitalization duration, survival, and clinical severity of COVID-19.
Results: Twenty-eight (%39.4) of the patients were male and 43 (%60.6) were female, and the mean age was 55.7±20.7 years. There was a significant difference between the groups of COVID-19 clinical severity in terms of age, fibrinogen, albumin, FAR, D-dimer, and CRP values (all p values were <0.001). Also, significantly higher fibrinogen, FAR, D-dimer, and CRP values were found in patients hospitalized longer, while the albumin level was lower in these patients (all p values were <0.001). FAR values were higher and albumin values were lower in non-surviving patients compared to surviving patients (p=0.025 and p<0.001, respectively).
Conclusion: FAR levels may be useful in predicting mortality risk in COVID-19 patients. In addition, it may be helpful and useful in determining the prognosis since it has higher levels as the severity of the disease and the length of hospital stay increase.