bluuebunny/crossref_metadata_2025 huggingface dataset:
Olmesartan-induced Gastropathy: an important cause to think about in refractory peptic ulcer disease
Authors: Simas Diogo , Gonçalves André Ruge , Gomes Plácido , Russo Pedro , Amado Cristina M. , Vasconcelos Helena
Published: December 2024

Background: Angiotensin receptor antagonists (ARB) are a pharmacological class widely used as antihypertensive therapy. Recently, a relationship between these agents and gastrointestinal disease has been described, namely enteropathy, gastropathy, and microscopic colitis. The mechanism is unknown, but it is thought that a cell-mediated immune reaction is involved and does not appear to be a class effect. Treatment consists of stopping the drug and rechallenge can confirm the diagnosis.
Case presentation: An 85-year-old man with a history of hypertension treated with olmesartan/hydrochlorothiazide for 12 years presented to the emergency department with months of epigastric pain, without vomiting, blood loss, diarrhea, or weight loss. A recent upper gastrointestinal endoscopy (UGE) showed congested mucosa, irregular erosions, and friability in the distal body, notch, and antrum. Histology revealed moderate chronic gastritis, severe inflammatory activity, abundant eosinophils, intestinal metaplasia with low-grade dysplasia, and marked atrophy, with no signs of malignancy or Helicobacter pylori (Hp). The patient had previously been treated by his family doctor with lansoprazole and sucralfate, without improvement, and was subsequently discharged on esomeprazole with a referral for a gastroenterology consultation.
Three months later, a follow-up UGE showed persistent erosions despite good adherence to esomeprazole. Hp serology was positive, and the patient was started on bismuth-based quadruple therapy. A post-treatment urea breath test confirmed Hp eradication.
Six months later, UGE still showed multiple ulcers in the distal body and antrum. Olmesartan was switched to lisinopril, and after another six months, a follow-up UGE showed no ulcers or erosions. Biopsies revealed reduced inflammation and no dysplasia, indicating histological improvement. Olmesartan-induced gastropathy was diagnosed.
Conclusions: This case report illustrates olmesartan-induced gastropathy, an important diagnosis to consider in cases of non-Hp gastritis and refractory peptic ulcer disease.
Spinal anesthesia vs general anesthesia in the endoscopic management of proximal ureteral stones: A critical evaluation focusing on the total anesthesia time
Authors: Bulbul Emre , Ilki Fahri Yavuz , Yitgin Yasin , Ustun Fatih , Sezer Ali , Erten Ela , Yitgin Emine , Bedir Selahattin , Sarica Kemal
Published: December 2024

Introduction: This study was aimed to compare spinal and general anesthesia methods in endoscopic management of proximal ureteral stones with a particular emphasis on total anesthesia time.
Methods: A total of 246 adult patients undergoing ureteroscopic management for proximal ureteral stones between January 2021 and March 2023 were enrolled. Two different types of anesthesia namely spinal (Group 1, n=109) and general (Group 2, n=137) anesthesia were applied during these procedures.
Results: The mean total anesthesia time of Group 1 was statistically significantly shorter than that of Group 2 (61.4±28.7 and 93.7±29.2 min, respectively, p=0.013). While 92.7% of patients in Group 1 were stone free after the interventions, this value was 92 % in Group 2 (p=0.828). There was no statistically significant difference between the two groups regarding peri- (p=0.126) or postoperative (p=0.284) complications.
Conclusions: Our results demonstrated well that both spinal and general anesthesia methods could be applied in a successful and safe manner in the endoscopic management of proximal ureteral stones. However, a shorter total anesthesia time under spinal anesthesia could be anticipated during endoscopic management of proximal ureteral stones.
„Aus dem Nebel herausgekommen“ – Eine Falldarstellung zur Behandlung der Anhaltenden Trauerstörung mit der integrativen kognitiven Verhaltenstherapie
Authors: Rueger Mirjam Sophie , Steil Regina , Heidenreich Thomas
Published: December 2024

Hintergrund: Die Anhaltende Trauerstörung (ATS), welche mittlerweile in ICD-11 und DSM-5-TR aufgenommen wurde, ist mit einer verringerten Lebensqualität und häufigen Komorbiditäten assoziiert. Es sind spezifische Behandlungselemente wie Exposition des schlimmsten Verlustmomentes vorgeschlagen, um Symptome der ATS, wie Sehnsucht nach oder Beschäftigung mit der verstorbenen Person ausreichend zu adressieren.
Fallbericht: Herr T. stellte sich mit Symptomen einer ATS nach dem Tod seiner Mutter eigeninitiativ zur ambulanten Einzeltherapie vor. Die Behandlung wurde mithilfe der integrativen kognitiven Verhaltenstherapie nach dem Manual von Rosner und Kolleg:innen (engl. Prolonged Grief Cognitive Behavioral Therapy; PG-CBT) ergänzt durch Elemente der Dialektisch Behavioralen Therapie nach Linehan (DBT) durchgeführt. Nach Ende der neunmonatigen Behandlung lag eine vollständige Remission der ATS-Symptomatik vor, wobei Herr T. berichtete, seine innere Zufriedenheit zurückerlangt zu haben.
Schlussfolgerungen: Diese Kasuistik verdeutlicht exemplarisch den Einsatz des Manuals von Rosner und Kolleg:innen. Dabei sollen potenzielle Berührungsängste mit dem noch neuen Störungsbild reduziert und dazu ermutigt werden, eine ATS nach dem Verlust von nahestehenden Menschen gezielt zu erfragen und zu behandeln.
Exposição “ pólis: viver na cidade grega antiga ”: uma documentação
Authors:   Universidade de São Paulo. Faculdade de Educação, Moura Cleberson Henrique de
Published: December 2024

Este livro analisa a Exposição “pólis: viver na cidade grega antiga”, concebida e produzida no âmbito do Museu de Arqueologia e Etnologia da Universidade de São Paulo. Dessa forma, apresenta-se a partir da perspectiva de um museu universitário situado em uma instituição universitária pública, de modo que alguns aspectos relevantes dessa exposição são consequentes desta circunstância. Apresenta também a documentação da exposição e ação educativa Pólis, bem como as tecnologias digitais empregadas de forma contextualizada dentre as atividades do MAE-USP e seu histórico de desenvolvimento de exposições em geral. Desta forma, a pesquisa tem seu objeto de estudo circunscrito à mencionada exposição na temática da Arqueologia do Mediterrâneo, realizada pelo MAE-USP entre 2016 e 2017, sob coordenação geral da arqueóloga Profa. Dra. Elaine Farias Veloso Hirata.
Denatonium inhibits RANKL-induced osteoclast differentiation and rescues the osteoporotic phenotype by blocking p65 signaling pathway
Authors: Lee Sheunghun , Lee Hyerim , Jang You-Jee , Lee Kyubin , Kim Hye-Jung , Lee Jung Yeol , Kim Jin-Man , Park Sunyou , Song Jin Sook , Lee Ji Hoon , Hyun Tae Kyung , Park Jae-Il , Yi Sun-Ju , Kim Kyunghwan
Published: December 2024

Background

Bone remodeling is a critical process that maintains skeletal integrity, orchestrated by the balanced activities of osteoclasts, which resorb bone, and osteoblasts, which form bone. Osteoclastogenesis, the formation of osteoclasts, is primarily driven by NFATc1, a process activated through c-Fos and NF-κB signaling pathways in response to receptor activator of nuclear factor κB ligand (RANKL). Dysregulation of RANKL signaling is a key contributor to pathological bone loss, as seen in conditions such as osteoporosis.

Methods

We investigated the effects of denatonium, a known bitter compound, on RANKL-induced osteoclast differentiation. We used RNA sequencing (RNA-seq) to analyze gene expression profiles in osteoclast precursors treated with denatonium. Transcription factor prediction analysis was conducted to identify key targets of denatonium action. Additionally, we performed Western blotting to examine the phosphorylation status of AKT and p65, crucial components of the NF-κB pathway. Chromatin immunoprecipitation (ChIP) assays were employed to assess the binding of p65 to promoter regions of osteoclast-related genes. Finally, we tested the therapeutic potential of denatonium in a mouse model of osteoporosis.

Results

Our findings demonstrated that denatonium significantly inhibited RANKL-induced osteoclastogenesis by targeting the p65 pathway. RNA-seq analysis revealed a downregulation of osteoclast-related genes following denatonium treatment, corroborated by transcription factor prediction analysis, which highlighted p65 as a key target. Denatonium effectively blocked the phosphorylation of AKT and p65, key steps in NF-κB activation. ChIP assays further confirmed that denatonium reduced the enrichment of p65 at promoter regions critical for osteoclast differentiation. In vivo, denatonium treatment in an osteoporosis animal model led to a significant restoration of bone health, demonstrating its potential as a therapeutic agent.

Conclusions

This study identifies denatonium as an inhibitor of RANKL-induced osteoclast differentiation, potentially acting through suppression of the p65 signaling pathway. The ability of denatonium to downregulate osteoclast-related genes and inhibit key signaling events highlights its potential as a candidate for further investigation in the context of bone loss and osteoporosis.
Effects of probiotics in elderly hospitalized tube-fed patients with antibiotics use
Authors: Hsia Chu-Hsuan , Su Hsiu-Yueh , Chen Yue-Hwa , Chuang Han-Chuan , Chien Yi-Wen
Published: December 2024

Background

Several studies revealed the beneficial effects of probiotics against the incidence of antibiotic-associated diarrhea of hospitalized patients but it is rarely to assess the nutrition status. This study investigated the effects of probiotics in elderly hospitalized tube-fed patients with antibiotics use and is the first study that concerns the nutritional status among these patients.

Methods

Elderly hospitalized tube-fed patients who were using antibiotics were recruited. Probiotics were given within 48 h after their first antibiotic therapy, and then twice daily 2 h after consuming antibiotics and a meal; the probiotics were continued to use for an additional 7 days after completion of antibiotics therapy. Anthropometric data, laboratory data, medication records, nutritional status, nutrition intake and data on stool form were collected.

Results

Twenty-nine patients served as probiotic group. 11 patients completed the study in both groups. In probiotic group, the stool form was found to exhibit no significant differences between the beginning and end of antibiotics therapy (5.5 ± 0.8 vs 5.1 ± 1.1, p = 0.21), but the stool frequency significantly decreased (2.0 ± 1.0 vs 1.6 ± 0.7, p = 0.05). In control group, the stool form between the beginning and end of antibiotics therapy exhibited significant improvement (5.6 ± 1.4 vs 4.5 ± 1.4, p = 0.01), but not in the frequency (2.7 ± 2.1 vs 2.4 ± 1.5, p = 0.1). The initial NRS 2002 score of the probiotic and control groups were similar. (3.6 ± 1.7 vs 3.7 ± 1.8, p = 1.00), and their nutrition status both significantly improved during the last visit before discharged (2.6 ± 0.9 vs 2.9 ± 1.3).

Conclusion

Probiotic supplementation in elderly hospitalized tube-fed patients significantly reduced stool frequency during antibiotic treatment. Improvements in stool form were observed only during the follow-up period. Nutritional status remained stable, with patients' nutritional needs adequately met throughout the study.
Associations of risk factors and the number of risk factors with the classification, GMFCS level and comorbidities with cerebral palsy: a retrospective study
Authors: Gong Chao , Zeng Pei , Lian Beibei , Li Jiawei , Liu Jiahao , Liu Yuanyuan , Fang liya , Tian Huiling , Wang Luchuan , Jiang Zhimei , Guo Jin , Zhou Shaobo
Published: December 2024

Objective

The objective was to explore the characteristics of risk factors in children with cerebral palsy (CP), focusing on the effects of single risk factors and the number of risk factors on the classification, GMFCS level, and comorbidities of children with CP.

Methods

The medical records of children with CP hospitalized from 2015 to 2023 were reviewed. The effects of nine risk factors, such as hyperbilirubinemia, asphyxia, and HIE, on the classification, GMFCS level and comorbidities of children with CP were studied.

Results

In Part 1, among the 536 children with CP, 476 (88.8%) had obvious risk factors. Preterm birth and/or low birth weight were the most common risk factor (243 cases (45.3%)). CP combined with two risk factors was the most common, with 147 cases (27.4%). In Part 2, neonatal seizures were associated with epilepsy, and HIE and hyperbilirubinemia were associated with intellectual disability. Asphyxia was associated with high GMFCS levels and mixed CP. Preterm birth and/or low birth weight was associated with spastic diplegia, and hyperbilirubinemia was associated with involuntary movement. In Part 3, the number of risk factors in children with CP with epilepsy and/or hearing impairment seemed to be lower, but those with spastic quadriplegia were more likely to have more risk factors (≥ 4). In the six groups with 1–6 risk factors, intellectual disability and a GMFCS level ≥ level IV were more common in the various risk factor groups, but spastic hemiplegia and ataxia were less common.

Conclusion

Most children with CP have apparent risk factors, and the combination of two risk factors is relatively common. Preterm birth/low birth weight is the most common risk factor. The analysis of single risk factors revealed that the risk factors were related to the classification, GMFCS level and comorbidities. This correlation is consistent with the current research. Risk factors were more common in children with severe CP, high GMFCS levels, spastic quadriplegia, and intellectual disability.
The LILRB family in hematologic malignancies: prognostic associations, mechanistic considerations, and therapeutic implications
Authors: Hodges Alan , Dubuque Rachel , Chen Shu-Hsia , Pan Ping-Ying
Published: December 2024

The leukocyte immunoglobulin-like receptor B (LILRB) proteins, characterized by their transmembrane nature and canonical immunoreceptor tyrosine-based inhibitory motifs (ITIM) signaling, play a pivotal role in maintaining immune homeostasis and are implicated in the pathogenesis of various disease states. This comprehensive review will focus on the intricate involvement of the LILRB family in hematologic malignancies. These receptors have emerged as valuable diagnostic and prognostic biomarkers in leukemia, lymphoma, and myeloma. Beyond their prognostic implications, LILRBs actively shape the immune microenvironment and directly influence the disease pathogenesis of hematologic malignancies. Furthermore, their identification as potential therapeutic targets offer a promising avenue for precision medicine strategies in the treatment of these disorders. Currently, multiple LILRB directed therapies are in the preclinical and clinical trial pipelines. This review underscores the multifaceted role of the LILRB family in hematologic malignancies, highlighting their significance from diagnostic and prognostic perspectives to their broader impact on disease pathophysiology and as valuable therapeutic targets.
High-velocity impact studies of honeycomb sandwich structures with Al/Al2O3 and Al/B4C functionally graded plasma sprayed faceplates
Authors: D Muniraj , S Vignesh , V. M Sreehari
Published: December 2024

High-velocity impact response of honeycomb sandwich structures (HSS) with Al/Al2O3 and Al/B4C functionally graded plasma-sprayed (FGPS) faceplates are investigated in present work. FGPS structures improve the specific material properties and make the structure distinct from the substrate material. The metal and ceramic content was varied across the thickness of the FGPS coating in the present work. The HSS having honeycomb core sandwiched between two Al/Al2O3 FGPS faceplates were manufactured initially. Further, HSS having honeycomb core sandwiched between two Al/B4C FGPS faceplates were manufactured. Such HSS are repeatedly impacted with a spherical projectile using a single-stage gas gun at a constant impact energy of 260 J, and the results are quantified and compared. The central deflection and dent diameter of FGPS plates as well as HSS were determined, and they increased with the number of impacts. The HSS’s energy absorption was dissipated by top faceplate indentation and core compression. The incorporation of a core prevented FGPS coating delamination and top faceplate penetration. The Al/Al2O3 and Al/B4C FGPS faceplates had dent diameters that were 14.30% and 18.70% smaller than the non-coated Al 6061-T6 faceplate, respectively, which proves the enhancement of high-velocity impact resistance through FGPS coating. The central deflection and dent diameter of the Al/B4C FGPS HSS are 6.04% and 3% lesser than the Al/Al2O3 FGPS HSS, respectively. The energy absorption of the Al/B4C FGPS HSS is better than that of the Al/Al2O3 FGPS HSS. As a result, the present research enhances the knowledge on the impact energy absorption of two distinct FGPS coated plates and HSS, which is highly useful in aerospace and defence applications.
Novel digital technique for assessing circumferential peri-implant bone height
Authors: Sokolowski Armin , Gottschalk Benjamin , Glockner Sebastian , Steyer Elisabeth , Kalinova Katarina , Lorenzoni Martin , Sokolowski Alwin
Published: December 2024

Objective

To introduce a novel digital technique for precise assessment of peri-implant bone heights, enhancing accuracy and objectivity in dental implantology research.

Methods

This study utilized digital intraoral scans and digitized impressions obtained during implant exposure surgery, combined with computer-aided design (CAD) software, to measure peri-implant bone heights accurately during flap-raising procedures. The peri-implant bone measurements were quantified circumferentially and validated through a comparative analysis of intraoral and extraoral scans.

Results

The technique demonstrated high precision, with a strong correlation (ICC = 0.902) between bone heights determined from intraoral and extraoral scans, highlighting minimal deviations and similar measurement outcomes. This approach enables comprehensive circumferential data and surface area measurements of peri-implant bone levels.

Conclusion

The proposed digital technique provides an objective, reliable method for peri-implant bone height assessment, offering precise, reproducible data that addresses the limitations of traditional probing and conventional imaging methods. This technique has broad applicability in dental implantology research, particularly for assessing peri-implant bone levels when a flap is raised.
Utilization and associated factors of growth monitoring and promotion services among young children in Gorkha district of Nepal
Authors: Upadhyay Jagat Prasad , Paneru Damaru Prasad , Sharma Yam Prasad , Khadka Nava Raj
Published: December 2024

Introduction

Promotion of child health during the first thousand days from conception to the child’s second birthday is vital for survival, growth and development. Growth monitoring and promotion services are key to the early detection of growth faltering and preventing malnutrition and promoting child health. This study aimed to assess the utilization of Growth Monitoring and Promotion (GMP) services and its associated factors among young children in Gorkha district of Nepal.

Methods

A community-based cross-sectional study was conducted in the Gorkha district, involving 290 mother-child pairs, from April 2024 to June 2024. Multistage random sampling was used to select mothers. Data was collected through face-to-face interviews using structured questionnaires. Descriptive statistics and inferential statistics involving multivariate logistic regression analyses were performed to identify the factors associated with GMP service utilization.

Results

Only 5.5% of children had completed the recommended 24 GMP visits according to protocol, while 23.8% utilized GMP services more than 15 times, which represents the 75th percentile of service utilization. Mothers who had good knowledge had significantly higher (adjusted OR = 4.23, 95% CI: 2.070–8.650, p < 0.001) GMP service utilization among their children than those counterpart mothers with poor knowledge about the GMP services. The main reasons for not regular utilizing GMP services included the time constraints and their household responsibilities (85%).

Conclusion

This study reported the low utilization of GMP services among children in Gorkha district. Maternal knowledge on GMP service emerged as the primary predictor of GMP service utilization and maternal engagement in the household activities explores as a leading barrier to GMP service utilization. Enhancing maternal knowledge through community engagement strategies and improving the monitoring mechanism within the health systems could increase GMP utilization.
Sequential pulmonary functions in survivors of leptospirosis pulmonary haemorrhage syndrome: a prospective cohort study
Authors: Priyankara Dilshan , Ruwanpathirana Pramith , Rambukwella Roshan , Perera Nilanka
Published: December 2024

Background

Leptospirosis, a spirochaete infection, can lead to Leptospirosis Pulmonary Haemorrhage Syndrome (LPHS), which requires intensive care admission and has a high mortality. Although data on short-term outcomes are available, the long-term respiratory sequelae of LPHS survivors are not known. We aimed to identify the post-discharge pulmonary functions and functional limitations in survivors of LPHS.

Methods

We conducted a prospective cohort study from January to December 2022 at the Medical Intensive Care Unit (ICU) of the National Hospital of Sri Lanka to assess the sequential changes in the spirometry parameters in patients who survived LPHS. The Forced Vital Capacity (FVC) and Forced Expiratory Volume in 1 s (FEV1) were measured on the day of discharge from the ICU (D0), 7th day after discharge (D7) and 28th day after discharge (D28). The predicted lung volume was calculated using the gender, age and height as per standard protocol. Physical and functional role limitations were assessed on D28 using the modified Medical Outcomes Study Questionnaire Short Form 36 Health Survey (SF-36).

Results

Twenty-one patients with a mean age of 44 years (SD 16.07) were enrolled for the study. The majority were male patients (n = 19, 90.5%). Leptospirosis was serologically confirmed in all individuals. Seventeen (81%) patients had reduced FEV1 and FVC on D0, indicating a restrictive lung abnormality. FVC and FEV1 improved during the first 7 days (p < 0.01) but did not change significantly afterwards. Only seven individuals (33.3%) achieved a normal FVC (exceeding 80% of the predicted volume) at D28. However, 19 (90.5%) individuals achieved a normal FEV1 (exceeding 80% of predicted volume) by D28. In our study, administering corticosteroids during ICU stay did not impact lung recovery in FVC (p = 0.521) or FEV1 (p = 0.798). The participants did not have significant physical, functional, and role limitations at D28.

Conclusions

The spirometry measurements of individuals diagnosed with LPHS significantly improved during the first 7 days. Most survivors did not have a functional impairment despite the FVC not recovering to normal by D28.
Influence of Gas Accumulation on Rock Elasticity and Control Factors Analysis for Gas Chimney Formation
Authors: Ding Pinbo , Kuang Zenggui , Deng Wei , Xu Weiping , Zhang Feng , Li Xiang-Yang
Published: December 2024

Gas chimneys can often be observed in marine seismic profiles, which are usually related to gas accumulation in shallow layers and their impacts on rock elasticity. In order to clarify the impact of various geological factors to elastic wave propagation, an experimental study is conducted to elucidate the variation of rock elastic parameters in gas accumulated rocks. Gas accumulation simulations and real-time ultrasonic monitoring experiments are conducted in laboratory experiments. The control factors for gas chimney formation, such as pressure, porosity, fractures and fluids, are analyzed. It is found that high pore pressure provides favorable conditions for the formation of gas chimneys. Within the lower range of pore pressures, the P- wave velocity is more sensitive to gas changes, whereas the S- wave velocity is relatively insensitive. When the pore pressure is within a moderate range, the S- wave velocity is more sensitive than the P- wave velocity. At higher pore pressures, the influence of the pore pressure on the P- wave velocity is greater, and the influence on the S- wave velocity is smaller. The experimental results for low-porosity sandstone are significantly influenced by pore pressure, whereas the attenuation of P- and S- waves in high-porosity sandstone is controlled by porosity and less sensitive to changes in pore pressure. The presence of fractures has a significant impact on both velocity and amplitude, and the impact of fractures is no longer significant when the pore pressure is high. Injecting a small amount of gas into water saturated rocks can cause a strong attenuation of wave amplitude, indicating that the influence of mixed fluids on amplitude is more significant than other factors. This study provides a theoretical explanation for gas chimney formations in shallow loose rocks and help to analyze seismic wave propagation properties in the field.
CAMONCO 2: Results From a Randomized Controlled Trial Comparing Open Dialogue About Complementary Alternative Medicine and Standard Care on Patients' Quality of Life
Authors: Stie Mette , Timm Signe , Delmar Charlotte , Nørgaard Birgitte , Jensen Lars Henrik
Published: December 2024

The rising prevalence of complementary alternative medicine (CAM), including for example, dietary supplements, massage, and acupuncture, among patients with cancer underscores the necessity of integrating open dialogue about complementary alternative medicine (OD-CAM) into oncology treatment and care.

PURPOSE

This randomized controlled trial aimed to investigate the impact of OD-CAM on patients' quality of life (QoL), emotional well-being, decision regret, and survival. Patients undergoing antineoplastic treatment were randomly allocated to receive standard care (SC) plus OD-CAM or SC alone. The primary end point was patient-reported QoL 8 weeks after enrollment. Secondary end points included patient-reported QoL, anxiety, depression, and decision regret at 12 and 24 weeks after enrollment and overall survival at 52 weeks after enrollment.

MATERIALS AND METHODS

Patient-reported outcomes were evaluated using the European Organisation for Research and Treatment of Cancer Computer Adaptive Test Core questionnaire, the Hospital Anxiety and Depression questionnaire, and the Decision Regret Scale.

RESULTS

A total of 210 patients were equally randomly assigned, leaving 105 patients in each group. No significant differences were observed in QoL, well-being, decision regret, or survival between the groups.

CONCLUSION

OD-CAM did not demonstrate superiority over SC in enhancing the QoL and well-being of patients undergoing antineoplastic treatment. Increased levels of anxiety and fatigue might result from OD-CAM, underscoring the importance of the person-oriented approach inherent in OD-CAM. OD-CAM may hold clinical significance, especially for those already inclined toward CAM; however, further investigation into the essential components of OD-CAM and the characteristics of patients who are most likely to experience significant improvements of OD-CAM is recommended.
Speculative Light
Authors: Elias Amy J.
Published: December 2024

The introduction to the volume presents biographical background about Beauford Delaney and James Baldwin and discusses the history of their friendship and their mutual influences. It provides a comprehensive summary of scholarship conjoining the two artists and explores shared political and aesthetic values of these Black, queer, twentieth-century US artists.
“You Pay for Your Life with Your Life”
Authors: Pavlić Ed
Published: December 2024

In this chapter, Ed Pavlić accounts for the interlude in James Baldwin's life between leaving Hollywood in 1969 and the summer of 1970—immediately before his full-time residence in Saint-Paul-de-Vence, France, where he would complete No Name in the Street. Baldwin aimed to retreat from his public and moment-by-moment engagement with American racial politics so that he could assess what had happened during the 1960s, reengage his private life, and figure out where to go next. The chapter covers his time in Istanbul, including the months in which he lived with Beauford Delaney, and is based on letters Baldwin wrote to his brother David during that time.
Chiaroscuro, Delaney's Aesthetic Vision, and Baldwin's “Sonny's Blues”
Authors: Miller D. Quentin
Published: December 2024

In this chapter, D. Quentin Miller argues that James Baldwin’s 1957 short story “Sonny's Blues” was published at a point in his career when his attention to visual aesthetics was catalyzed and refined by Beauford Delaney. Reframing “Sonny’s Blues” in terms of its visual elements both affords a deeper understanding of Delaney’s influence on Baldwin and highlights the story’s essential concerns with the revelation of a complex psychological self. The complete self emerges through the interplay of lightness and dark, metaphorical indicators of the interplay between surface (the facets of others that we perceive) and depth (the mysterious facets hidden in one’s private interior). Chiaroscuro, the painting technique that corresponds to this verbal play, is at its core an artistic emphasis on the contrast and interplay of light and darkness to reveal depth and dimension.
Baldwin and Delaney
Authors: Choudhury Indie A.
Published: December 2024

In this chapter, Indie A. Choudhury examines the ways that Beauford Delaney and James Baldwin conflated sight and visibility and how performance became the functional apparatus that mediated the relationship between these modes. Using Baldwin’s play Blues for Mister Charlie (1964) and Delaney’s painting The Time of Your Life (1945) as examples, the essay asserts that performance offered both artists the opportunity not only to perceive Blackness but also to render it visible. Performativity became a way both to navigate and to displace already given codes and stereotypes about the expectations associated generally with race and gender, and specifically about Black male sexuality. For Baldwin, the lesson of Delaney’s seeing was that visual acuity was connected to a perceptual, cognitive, and synesthetic acuity that for each artist was linked intrinsically to Black sight and the capaciousness of Black existence beyond the binaries of light or dark, black or white.
“Architects of the Spirit”
Authors: Schriber Abbe
Published: December 2024

In this chapter, Abbe Schriber illustrates how Beauford Delaney’s canvases elicit new expressive modes not through interiority, but through redefining vision as both visual and tactile. For Delaney, intimacy can be understood as an extension of seeing, and his relationships with James Baldwin and other close artist-friends, such as Herbert Gentry, are essential to reading his paintings not as indices of any form of social intimacy but as an intimacy borne of multisensory stimuli and affiliations and social exchanges embodied in the complexity of color. In the worked, dense chromatic surfaces of Delaney’s canvases is a retranslation, into forms of freedom, of the circumscription of queerness that resulted from heteronormative conventions of care shaped by US homophobia and racial segregation in the 1950s and 1960s.
Ηλεκτρικός χαρακτηρισμός και μοντελοποίηση των βαρίστορ
Authors: Στάικος Ευάγγελος
Published: December 2024

Στο πλαίσιο της διδακτορικής διατριβής αναπτύχθηκε μία γενικευμένη πειραματική μεθοδολογία για τον ηλεκτρικό χαρακτηρισμό και τη ανάλυση της συμπεριφοράς βαρίστορ οξειδίων μετάλλων υπό συνεχείς και εναλλασσόμενες τάσεις διαφόρων συχνοτήτων (45 Hz – 1 kHz) και υπό ηλεκτρομαγνητικούς παλμούς μεγάλου εύρους ενεργειακού και συχνοτικού περιεχομένου. Για τη μελέτη της απόκρισης βαρίστορ οξειδίων μετάλλων αναπτύχθηκαν νέες μαθηματικές σχέσεις για τον υπολογισμό του ρεύματος αγωγής, των απωλειών ισχύος και της ενέργειας καταπόνησής τους και αναπτύχθηκε μία πειραματική μεθοδολογία για τον προσδιορισμό της χαρακτηριστικής τάσης-ρεύματος, της δυναμικής αυτεπαγωγής και της εξαρτώμενης από τάση χωρητικότητας των βαρίστορ. Με βάση τα παραπάνω αναπτύχθηκε μοντέλο για την προσομοίωση της απόκρισης βαρίστορ στο πεδίο του χρόνου για το λογισμικό προσομοίωσης ηλεκτρομαγνητικών μεταβατικών καταστάσεων ATP-EMTP. Τα αποτελέσματα του προτεινόμενου μοντέλου βρέθηκαν σε ικανοποιητική συμφωνία με πειραματικά αποκτηθέντα δεδομένα όσον αφορά το ρεύμα αγωγής των βαρίστορ, την παραμένουσα τάση στα άκρα τους και την καταναλισκόμενη ισχύ και ενέργεια σε αντίθεση με αποτελέσματα τυπικών μοντέλων που χρησιμοποιούνται ευρέως σε πρακτικές εφαρμογές.
Corporate financial planning and budgeting
Authors: Zograb Mnacakanovich , Yana Yakovlevna , Ol'ga Viktorovna , Tat'yana Valentinovna
Published: December 2024

The textbook consists of ten sections in which the content and stages of the financial planning and budgeting process are consistently considered: financial planning and budgeting, financial responsibility centers, organization of planning and budgeting processes, methods of calculating planned financial indicators, formats of financial plans and budgets, sources of information for financial planning, control, analysis and regulation of financial plans. The processes of forming a planning system and methods of organizing a system for monitoring the achievement of planned financial indicators are disclosed.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
It is intended for students and teachers of economic universities, graduate students, researchers, practitioners in the field of financial activities of organizations.
Territorial marketing: theory and practice
Authors: Sachuk Tat'yana
Published: December 2024

The textbook presents the modern concept of territorial administration. The main issues of territorial marketing are considered: the marketing environment of the territory, the subjects and the complex of means of implementing territorial marketing, consumer behavior, macro- and micro-segmentation, differentiation and competitiveness of the territory, positioning and branding of the territory, etc. The textbook reflects such categories as public benefit, local community, cultural, social and symbolic capitals of the territory, tourist destination, institutions of territorial development, etc. The process of client-oriented strategic planning of socio-economic development of the territory based on territorial marketing is presented. The process of organizing and managing territorial marketing is shown. Specific examples of territorial marketing of a country, region, municipality, or locality are given.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
Designed for bachelors studying in the field of "State and municipal management", it will be useful for masters and postgraduates of the field of training "Management in state and municipal management", as well as marketers, entrepreneurs, communication managers, urbanists, specialists in the field of strategic management — anyone who solves issues of complex socio-economic development of the territory of various scale.
Analysis of models and algorithms for optimizing the cutting of one-dimensional timber
Authors: Bugaev Yuriy , Korobova Lyudmila Lyudmila Anatol'evna , Shurupova Irina
Published: December 2024

The work is devoted to research in two directions. First, a comprehensive analysis of existing cutting optimization algo-rithms was carried out using the example of solving the problem of maximizing the cylindrical volume of output segments from a whip. A detailed description of the consid-ered algorithms is provided. Based on their theoretical anal-ysis and numerical experiments, it was found that the best method is one of the variants of dynamic programming. Secondly, the most suitable variant of the whip forming model is determined. The results of cutting obtained using the averaged V. S. model are compared. Petrovsky and an individual model of a real whip, based on the results of V. N. Vasiliev's research. It is shown that the first model does not take into account the local features of the shape of a real whip and, as a result, the cutting schemes obtained from it may not be optimal. For a more reliable verification of this fact, as a development of the conducted research, it is pro-posed to collect sufficient statistics, for example, by simulat-ing the cutting of a large set of real whips. It is recommend-ed to use a model in production that takes into account the individual characteristics of each cutting object as much as possible. Such a model can be built in real time based on operational information about the size and quality of each cutting object obtained by measuring and diagnosing it with automatic devices. This is greatly facilitated by the achieve-ments in the development and implementation of digital technologies and sensors of standard sizes of timber in tim-ber processing
System analysis of acoustic properties of voice sirens
Authors: Epifanov Evgeniy , Asminin Viktor , Sazonova Svetlana
Published: December 2024

The acoustic properties of fire alarm systems are considered. The analysis and correction of the existing system of classification of fire alarm systems has been carried out. Shortcomings have been identified in the requirements for fire safety monitoring for voice alerts and for the certification testing procedure for fire-fighting voice alarms. The completeness of linguistic information, which is the basic standard for the required completeness of information for evacuees in case of fire, is analyzed. The structure of the sound field in the room is considered, taking into account interference during the operation of fire alarm systems. For real fire alarms, the necessity of using passport data is justified in order to obtain acoustic characteristics for such alarms as a source of not only direct, but also reflected sound. These characteristics can be used to calculate the sound field of the premises, as well as to obtain information about voice information for warning and evacuation control systems. The main factors influencing the fire early warning system have been identified, as well as their assessment and systematization. To form standard requirements for the results of new methods of acoustic design of warning and evacuation management systems to be developed, the disadvantages of existing methods for calculating fire alarm systems are displayed
Investigation of the structure of a tropical cyclone based on the analysis of satellite video data using the method of almost periodic analysis
Authors: Paramonov Aleksandr , Kalach Andrey , Kravchenko Andrey
Published: December 2024

At the moment, research on forecasting and modeling of emergencies and the phenomena accompanying their occurrence is relevant. The causes of dangerous situations are, among other things, natural phenomena. One of these phenomena is a tropical cyclone, which is capable of causing gale force winds, tornadoes and high-intensity precipitation. The study was conducted using the example of tropical cyclone Milton, which formed from October 5 to October 10, 2024 and caused a wide public response. It should be noted that a tropical cyclone formed on October 5, 2024 in the Gulf of Mexico and broke up in the Atlantic Ocean on October 10, 2024. At the same time, residents of the US state of Florida fell under the brunt of the dangerous phenomenon, and the main causes of destruction and casualties among the population were the tornadoes accompanying the typhoon and strong winds. The analysis of the full dynamics of a tropical cyclone was performed in order to identify characteristic structural areas using an almost periodic analysis apparatus. The characteristic almost periodic values of tropical cyclone zones are revealed, and, based on a detailed analysis, the factors for further research and the possibility of improving the results obtained from the almost periodic analysis of satellite data with tropical cyclones are outlined
Integration of Personalized and Adaptive Approaches in Modern Educational Practice
Authors: Yulina Galina , Alieva P.
Published: December 2024

This article compares personalized and adaptive learning in the modern educational process. It analyzes the main features of each approach, focusing on the goals and methods of implementation. Particular attention is paid to the impact of these approaches on meeting the individual needs of students and improving their academic performance. The technologies used to monitor and analyze students and allow adapting the course content in real time are also discussed. The relevance of this article is due to the growing interest in adaptive learning technologies that can significantly improve the efficiency of the educational process. In the context of constantly changing learning requirements and the desire for individualization, the need to develop adaptive approaches is becoming especially relevant. The purpose of the study is to identify the main directions and elements of adaptive learning and determine the impact of these approaches on learning success. The following objectives were set within the study: to analyze existing personalized and adaptive learning technologies, assess their impact on learning outcomes and identify practical aspects of implementing such technologies in the educational process. The study used the method of systematic analysis of scientific publications and methodological materials to evaluate existing approaches in the field of personalized and adaptive learning. The differences and similarities between these concepts were studied based on modern learning models and educational strategies applied in various contexts. The results of the study show that personalized and adaptive learning are effective approaches to the content and methods of teaching depending on the individual characteristics of students. It is shown that systematic monitoring of academic progress, dynamic correction of educational material and the use of combined methods of interaction with teachers contribute to the deepening of academic knowledge and increasing motivation of students. In conclusion, the article emphasizes that the synergy of personalized and adaptive learning can significantly improve the quality of the educational process and contribute to the effective achievement of learning goals.
A review on diagnosis and treatment approaches to calcium pyrophosphate deposition disease
Authors: Hosseinnejad Negar , Cygnarowicz Aleksandra , Wojtas Aneta Klaudia , Zabojska Krystyna , Korotko Urszula , Mandziuk Aneta , Witowska Kinga , Turemka Mariola , Biskupski Mikolaj , Sacher Karolina
Published: December 2024

Introduction and purpose of this work
CPPD is an arthropathy related to calcium pyrophosphate crystals’ deposition in joints triggering an inflammatory response leading to local articular damage. CPPD mainly affects the large and weight-bearing joints.In this review paper, our aim is to outline the current knowledge on epidemiology, origins, clinical manifest, diagnostical tools, new guidelines of the (ACR) and  (EULAR) and current treatment options for CPPD.
Methods:
We performed a systematic electronic search on PubMed, Medline and Google Scholar databases. The search results were limited to publications from 2002 to 2024, as well as key studies and reference books from earlier years.
Brief description of the state of knowledge
 CPP crystals in joints can lead to an inflammatory response and lead to joint damage. CPPD is the third most common reason of arthritis. Its origin is rather idiopathic, but there has been research showing the linkage of this disease to genetical background and some metabolic disorders.The treatment is chosen based on the phenotype of the disease.conventional pharmacological treatment includes NSAIDs, colchicine and corticosteroids. New opportunities to CPPD treatment have appeared thanks to biological medications which inhibit the inflammatory process.
Summary
Early diagnosis of CPPD, distinguishing it from other forms of arthritis and identifying the possible co-occurring diseases such as gout, rheumatoid arthritis and osteoporosis can help the clinicians to apply the proper treatment . Most patients are seniors  with several comorbidities, this is why it is important to choose the right treatment, which prevents exacerbation of the inflammatory process and ensures high quality of life for the patients.
The Impact of Excessive Sugar Consumption on Skin Health Analysis of Biological Mechanisms and Dermatological Effects
Authors: Dolata Natalia , Balcer Bartosz , Liszka Paweł , Pakuła Mateusz , Weimann Maja , Kruczkowska Adrianna , Stosiek Aleksandra , Cebula Agnieszka , Bulzacki Emil , Urbański Wojciech
Published: December 2024

Introduction and purpose: 
Excessive sugar consumption is one of the main dietary problem of the modern Western diet. Numerous studies have shown that a high intake of simple sugars is associated with an increased risk of developing various diseases such as obesity, type 2 diabetes, metabolic syndrome, and cardiovascular diseases. Moreover, the consumption of large amounts of sugar also affects skin condition, accelerating its aging and exacerbating the course of certain dermatological conditions. This study aims to present the underlying mechanisms of these processes and demonstrate the impact of a low-glycemic index diet on skin health. 
Description of the state of knowledge: 
The skin is the largest organ of the body, and its condition is closely linked to diet. Excessive sugar consumption can contribute to biochemical changes such as skin protein glycation, increased production of reactive oxygen species (ROS), and inflammation. The glycation process leads to damage of collagen and elastin fibers, which reduces skin elasticity and contributes to the formation of wrinkles. Elevated levels of MMP-1/MMP-2 and LOX in the skin can affect collagen fragmentation and disrupt its structural integrity. Studies have also shown that a high-glycemic index diet can exacerbate inflammatory conditions such as acne and psoriasis and promote hormonal imbalances. 
Conclusion: 
In summary, excessive consumption of simple sugars significantly affects skin condition through mechanisms such as glycation, inflammation induction, and hormonal disturbances. Therefore, a low-glycemic index diet may be an effective tool in the prevention and treatment of skin diseases. Future studies should focus on gaining a more precise understanding of these relationships and developing dietary recommendations to improve skin health.