bluuebunny/crossref_metadata_2025 huggingface dataset:
Does improving indoor air quality lessen symptoms associated with chemical intolerance?
Authors: Perales Roger B. , Palmer Raymond F. , Rincon Rudy , Viramontes Jacqueline N. , Walker Tatjana , Jaén Carlos R. , Miller Claudia S.
Published: January 2022

Aim:

To determine whether environmental house calls that improved indoor air quality (IAQ) is effective in reducing symptoms of chemical intolerance (CI).

Background:

Prevalence of CI is increasing worldwide. Those affected typically report symptoms such as headaches, fatigue, ‘brain fog’, and gastrointestinal problems – common primary care complaints. Substantial evidence suggests that improving IAQ may be helpful in reducing symptoms associated with CI.

Methods:

Primary care clinic patients were invited to participate in a series of structured environmental house calls (EHCs). To qualify, participants were assessed for CI with the Quick Environmental Exposure and Sensitivity Inventory. Those with CI volunteered to allow the EHC team to visit their homes to collect air samples for volatile organic compounds (VOCs). Initial and post-intervention IAQ sampling was analyzed by an independent lab to determine VOC levels (ng/L). The team discussed indoor air exposures, their health effects, and provided guidance for reducing exposures.

Findings:

Homes where recommendations were followed showed the greatest improvements in IAQ. The improvements were based upon decreased airborne VOCs associated with reduced use of cleaning chemicals, personal care products, and fragrances, and reduction in the index patients’ symptoms. Symptom improvement generally was not reported among those whose homes showed no VOC improvement.

Conclusion:

Improvements in both IAQ and patients’ symptoms occur when families implement an action plan developed and shared with them by a trained EHC team. Indoor air problems simply are not part of most doctors’ differential diagnoses, despite relatively high prevalence rates of CI in primary care clinics. Our three-question screening questionnaire – the BREESI – can help physicians identify which patients should complete the QEESI. After identifying patients with CI, the practitioner can help by counseling them regarding their home exposures to VOCs. The future of clinical medicine could include environmental house calls as standard of practice for susceptible patients.
Nationality and Equal Political Rights: A Necessary Link?
Authors: Samartzis Andreas
Published: January 2022

Main justifications for regarding common nationality as a necessary condition for holding equal political rights – Critique of collective self-determination, equal stakes, nature of political activity, and stability justifications – Rejection of the incommensurability of legitimacy and justice – Socioeconomic interdependence and liberal democratic values as the normative grounds for equal stakes – Risk of entrenchment of hostility among national groups as a consequence of a competitive conception of political activity – Instrumental value of stability – Stability through democratic inclusion – Possibility of sustainable pluralism through deliberative democracy – Modified version of the equal stakes argument – Equal political rights on the basis of long-term residence – Association of citizenship with nationality in contemporary European states – Redefinition of citizenship as top-down redefinition of nationality – Need to reconceptualise equal political rights independently of citizenship – Legal argument for interpreting references to popular sovereignty in national constitutions in accordance with long-term residence, rather than nationality – Available legal remedies
New Martian Dust Simulant JMDS‐1 and Applications to Laboratory Thermal Conductivity Measurements
Authors: Yu Wen , Zeng Xiaojia , Li Xiongyao , Wei Guangfei , Fang Jichao
Published: January 2022

Martian dust simulant (i.e., a terrestrial substitute for Martian dust) is the basis for experimentally investigating the properties of Martian dust and its effects on Mars exploration activities. In this study, we reported a new Martian dust simulant (Jining Martian Dust Simulant, called JMDS‐1), which was prepared based on terrestrial Jining basalt (90 wt%) and other mineral phases (i.e., 2 wt% magnetite, 2 wt% hematite, 2 wt% anhydrite, 2 wt% calcite, and 2 wt% kaolin). Measurements of JMDS‐1 dust simulant show that JMDS‐1 has a bulk composition, mineralogy, reflectance spectra, and particle characteristics similar to the Martian dust detected by Mars rovers. In addition, we measured the thermal conductivity of dust simulant, soil simulant, and dust‐soil simulant mixtures under simulated Martian conditions (i.e., −30°C; 500–1,000 Pa). The results reveal that the micro‐sized dust simulant has a thermal conductivity of ∼0.015 W/mK, which is two times lower than the thermal conductivity of sub‐millimeter sized soil simulant (i.e., ∼0.035 W/mK). This implies that the dust layer on Mars seems to play a significant role to change the thermal properties of surface materials.
Enhancement of Electron Density in the Ionospheric F2 Layer Near the First Contact of the Total Solar Eclipse on 21 August 2017
Authors: Tian Zhengyuan , Sui Yiyi , Zhu Shengting , Sun Yang‐Yi
Published: January 2022

It can be expected that a moon shadow of solar eclipse can largely reduce the ionospheric electron density (Ne) during the obscuration. However, in this study, the total electron content (TEC) from the ground‐based Global Navigation Satellite System receivers recorded a significant Ne enhancement over the continental United States (CONUS) near the first contact of the total solar eclipse on 21 August 2017. The ionosonde observations of the F2‐layer peak density (NmF2) and its height (hmF2) over Idaho National Lab (43.81°N, 112.68°W, 99.6% obscuration), ID, and Boulder (40°N, 105.3°W, 93.1% obscuration), CO, verified the unexpected early enhancement. The ionospheric Ne starts to enhance at ∼1520 UT (before the obscuration) and increases by ∼25% to ∼80% at ∼1600 UT (near the first contact) in the F2 layer. The early enhancement reveals the ascension of the F2 layer that tilted east over the CONUS.
Remagnetization Age and Mechanism of Cretaceous Sediments in Relation to Dyke Intrusion, Hainan Island: Tectonic Implications for South China and the Red River Fault
Authors: Meng Jun , Gilder Stuart A. , Li Yalin , Chen Yan , Zhang Chunyang , Zhou Zhaoyang , Liu Tao , Zhao Yinan , Wang Zihao , Wang Chengshan
Published: January 2022

Hainan Island lies near the Red River Fault, a prominent tectonic feature produced by the India‐Asia collision. There, we carried out a geochronologic and paleomagnetic study on Cretaceous rocks in order to better understand the kinematic history of the region. U‐Pb zircon dating of tuff intercalated in red bed sedimentary rocks yielded a concordant age of 106.6 ± 0.3 Ma; a mafic dyke intruding the red beds yielded a concordant age of 104.6 ± 0.7 Ma. Stepwise demagnetization experiments on 448 sedimentary rock samples and 191 dyke samples isolate solely normal polarities. Paleomagnetic directions of the dykes cluster in two distinct populations in geographic coordinates, indicating that dyke intrusion occurred in two pulses of limited duration (secular variation was not averaged) after tilting of the sediments. Baking of the sediments from the dykes only occurred near the contacts. Together with published data, the mean directions of 104 sites most tightly group at 58.3 ± 3.2% unfolding, indicative of a synfolding remagnetization, which can be constrained to have occurred within a 2 Myr period between sedimentation and dyke intrusion. We suggest that warm (50–100°C) fluid interaction during basin development led to new mineral growth spawning chemical remagnetization. The corresponding paleomagnetic pole at 81.5°N, 145.2°E (A95 = 2.4°) is indistinguishable from the coeval Eurasian reference pole, suggesting the South China Block has remained fixed to Eurasia since 105 Ma. A contour map of paleomagnetic rotations from 115 studies in the region shows that the Red River Fault roughly demarcates rotation magnitudes/signs, suggestive of a major tectonic boundary.
Advancing Cross‐Disciplinary Understanding of Land‐Atmosphere Interactions
Authors: Beamesderfer Eric R. , Buechner Christin , Faiola Celia , Helbig Manuel , Sanchez‐Mejia Zulia Mayari , Yáñez‐Serrano Ana María , Zhang Yunyan , Richardson Andrew D.
Published: January 2022

The evolution of disciplinary silos and increasingly narrow disciplinary boundaries have together resulted in one‐sided approaches to the study of land‐atmosphere interactions—a field that requires a bi‐directional approach to understand the complex feedbacks and interactions that occur. The integration of surface flux and atmospheric boundary layer measurements is therefore essential to advancing our understanding. The Land‐Atmosphere 2021 workshop (held virtually, June 10‐11, 2021) involved almost 300 participants from around the world and promoted cross‐discipline collaboration by way of talks from invited speakers, moderated discussions, breakout sessions, and a virtual poster session. The workshop focused on five main theme areas: “big picture” overview, instrumentation and remote sensing, modeling, water, and aerosols and clouds. In talks and breakout groups, there were frequent calls for more AmeriFlux sites to be instrumented for boundary layer height measurements, and for the development of some “super sites” where profiling instruments would be deployed. There was further agreement on the need for the standardization of various datasets. There was also a consensus that funding agencies need to be willing to support the sorts of large projects (including associated instrumentation) which can drive interdisciplinary work. Early‐career scientists, in particular, expressed enthusiasm for working across disciplinary boundaries but noted that there need to be more financial support and training opportunities so they would be better prepared for interdisciplinary work. Investment in these career development opportunities would enable today's cohort of early‐career scientists to advance the frontiers of interdisciplinary work over the next couple of decades.
Warmer Pliocene Upwelling Site SST Leads to Wetter Subtropical Coastal Areas: A Positive Feedback on SST
Authors: Fu Minmin , Cane Mark A. , Molnar Peter , Tziperman Eli
Published: January 2022

The early‐to mid‐Pliocene (5.3–3 Ma), characterized by warmer temperatures and similar CO2 concentrations to present day, is considered a useful analog for future warming scenarios. Geological evidence suggests that during the Pliocene, many modern‐day desert regions received higher levels of rainfall and supported large perennial lakes and wetter vegetation types. These wetter conditions have been difficult to reconcile with model predictions of 21st century drying over most subtropical land regions. Using an atmospheric General Circulation Model, we show that underestimates of Pliocene rainfall over certain areas in models may be related to insufficient sea surface temperature (SST) warmth simulated over relatively local eastern boundary current regions. When SSTs off the coast of California are raised to more closely match some proxy reconstructions, rainfall increases over much of adjacent western North America. Over the southwestern USA, this increased rainfall is mainly due to a convergent monsoonal circulation that develops over late boreal summer. A smaller wintertime increase in precipitation also occurs due to differences in rainfall associated with midlatitude cyclones. Wetter land conditions are expected to weaken upwelling‐favorable coastal winds, so that increased rainfall caused by coastal SST warming suggests a positive feedback that could help sustain wet, Pliocene‐like conditions.
FBXW7-mediated ERK3 degradation regulates the proliferation of lung cancer cells
Authors: An Hyun-Jung , Lee Cheol-Jung , Lee Ga-Eun , Choi Youngwon , Jeung Dohyun , Chen Weidong , Lee Hye Suk , Kang Han Chang , Lee Joo Young , Kim Dae Joon , Choi Jin-Sung , Cho Eun Suh , Choi Jong-Soon , Cho Yong-Yeon
Published: January 2022

Extracellular signal-regulated kinase 3 (ERK3) is an atypical member of the mitogen-activated protein kinase (MAPK) family, members of which play essential roles in diverse cellular processes during carcinogenesis, including cell proliferation, differentiation, migration, and invasion. Unlike other MAPKs, ERK3 is an unstable protein with a short half-life. Although deubiquitination of ERK3 has been suggested to regulate the activity, its ubiquitination has not been described in the literature. Here, we report that FBXW7 (F-box and WD repeat domain-containing 7) acts as a ubiquitination E3 ligase for ERK3. Mammalian two-hybrid assay and immunoprecipitation results demonstrated that ERK3 is a novel binding partner of FBXW7. Furthermore, complex formation between ERK3 and the S-phase kinase-associated protein 1 (SKP1)-cullin 1-F-box protein (SCF) E3 ligase resulted in the destabilization of ERK3 via a ubiquitination-mediated proteasomal degradation pathway, and FBXW7 depletion restored ERK3 protein levels by inhibiting this ubiquitination. The interaction between ERK3 and FBXW7 was driven by binding between the C34D of ERK3, especially at Thr417 and Thr421, and the WD40 domain of FBXW7. A double mutant of ERK3 (Thr417 and Thr421 to alanine) abrogated FBXW7-mediated ubiquitination. Importantly, ERK3 knockdown inhibited the proliferation of lung cancer cells by regulating the G1/S-phase transition of the cell cycle. These results show that FBXW7-mediated ERK3 destabilization suppresses lung cancer cell proliferation in vitro.
Effects of paternal overnutrition and interventions on future generations
Authors: Billah Md Mustahsan , Khatiwada Saroj , Morris Margaret J. , Maloney Christopher A.
Published: January 2022

In the last two decades, evidence from human and animal studies suggests that paternal obesity around the time of conception can have adverse effects on offspring health through developmental programming. This may make significant contributions to the current epidemic of obesity and related metabolic and reproductive complications like diabetes, cardiovascular disease, and subfertility/infertility. To date, changes in seminal fluid composition, sperm DNA methylation, histone composition, small non-coding RNAs, and sperm DNA damage have been proposed as potential underpinning mechanism to program offspring health. In this review, we discuss current human and rodent evidence on the impact of paternal obesity/overnutrition on offspring health, followed by the proposed mechanisms, with a focus on sperm DNA damage underpinning paternal programming. We also summarize the different intervention strategies implemented to minimize effects of paternal obesity. Upon critical review of literature, we find that obesity-induced altered sperm quality in father is linked with compromised offspring health. Paternal exercise intervention before conception has been shown to improve metabolic health. Further work to explore the mechanisms underlying benefits of paternal exercise on offspring are warranted. Conversion to healthy diets and micronutrient supplementation during pre-conception have shown some positive impacts towards minimizing the impact of paternal obesity on offspring. Pharmacological approaches e.g., metformin are also being applied. Thus, interventions in the obese father may ameliorate the potential detrimental impacts of paternal obesity on offspring.
Associations between weight loss history and factors related to type 2 diabetes risk in the Stop Diabetes study
Authors: Halali F. , Lapveteläinen A. , Aittola K. , Männikkö R. , Tilles-Tirkkonen T. , Järvelä-Reijonen E. , Absetz P. , Kolehmainen M. , Schwab U. , Lindström J. , Lakka T. A. , Pihlajamäki J. , Karhunen L.
Published: January 2022

Background

Frequent weight loss attempts are related to maladaptive eating behaviours and higher body mass index (BMI). We studied associations of several type 2 diabetes (T2D) risk factors with weight loss history, defined as the frequency of prior weight loss attempts, among Finnish adults at increased risk for T2D.

Methods

This study (n = 2684, 80% women) is a secondary analysis of the 1-year StopDia lifestyle intervention with digital intervention group, digital intervention + face-to-face counselling group, or control group. The frequency of prior weight loss attempts was categorized into five groups: no attempts/no attempts to lose weight, but trying to keep weight stable/1–2 attempts/3 or more attempts/ continuous attempts. Data on emotional eating and social/emotional nutrition self-efficacy were collected with a digital questionnaire. We assessed baseline differences between categories of weight loss history as well as the intervention effects.

Results

Altogether 84% of participants had attempted weight loss. Those with one or more weight loss attempts had higher BMI, larger waist circumference, and more emotional eating compared to ‘no attempts’ and ‘no attempts to lose weight, but trying to keep weight stable’ categories. The ‘no attempts’ category had the highest baseline fasting insulin, whereas it showed the largest decrease in this measure with the intervention. This change in fasting insulin in the ‘no attempts’ category was significantly different from all the other categories. Emotional nutrition self-efficacy slightly improved in the ‘no attempts’ category, which was significantly different from its concomitant decrease in the categories ‘1-2 attempts’ and ‘3 or more attempts’. The intervention group assignment did not affect the results.

Conclusions

Multiple attempts to lose weight may unfavourably affect T2D risk factors as well as lifestyle intervention outcomes. More research is needed on how weight loss frequency could affect T2D risk factors and how to design lifestyle interventions for individuals with frequent previous weight loss attempts.
Plasmonic–perovskite solar cells, light emitters, and sensors
Authors: Ai Bin , Fan Ziwei , Wong Zi Jing
Published: January 2022

The field of plasmonics explores the interaction between light and metallic micro/nanostructures and films. The collective oscillation of free electrons on metallic surfaces enables subwavelength optical confinement and enhanced light–matter interactions. In optoelectronics, perovskite materials are particularly attractive due to their excellent absorption, emission, and carrier transport properties, which lead to the improved performance of solar cells, light-emitting diodes (LEDs), lasers, photodetectors, and sensors. When perovskite materials are coupled with plasmonic structures, the device performance significantly improves owing to strong near-field and far-field optical enhancements, as well as the plasmoelectric effect. Here, we review recent theoretical and experimental works on plasmonic perovskite solar cells, light emitters, and sensors. The underlying physical mechanisms, design routes, device performances, and optimization strategies are summarized. This review also lays out challenges and future directions for the plasmonic perovskite research field toward next-generation optoelectronic technologies.
Newly identified HMO-2011-type phages reveal genomic diversity and biogeographic distributions of this marine viral group
Authors: Qin Fang , Du Sen , Zhang Zefeng , Ying Hanqi , Wu Ying , Zhao Guiyuan , Yang Mingyu , Zhao Yanlin
Published: January 2022

Viruses play critical roles in influencing biogeochemical cycles and adjusting host mortality, population structure, physiology, and evolution in the ocean. Marine viral communities are composed of numerous genetically distinct subfamily/genus-level viral groups. Among currently identified viral groups, the HMO-2011-type group is known to be dominant and broadly distributed. However, only four HMO-2011-type cultivated representatives that infect marine SAR116 and Roseobacter strains have been reported to date, and the genetic diversity, potential hosts, and ecology of this group remain poorly elucidated. Here, we present the genomes of seven HMO-2011-type phages that were isolated using four Roseobacter strains and one SAR11 strain, as well as additional 207 HMO-2011-type metagenomic viral genomes (MVGs) identified from various marine viromes. Phylogenomic and shared-gene analyses revealed that the HMO-2011-type group is a subfamily-level group comprising at least 10 discernible genus-level subgroups. Moreover, >2000 HMO-2011-type DNA polymerase sequences were identified, and the DNA polymerase phylogeny also revealed that the HMO-2011-type group contains diverse subgroups and is globally distributed. Metagenomic read-mapping results further showed that most HMO-2011-type phages are prevalent in global oceans and display distinct geographic distributions, with the distribution of most HMO-2011-type phages being associated with temperature. Lastly, we found that members in subgroup IX, represented by pelagiphage HTVC033P, were among the most abundant HMO-2011-type phages, which implies that SAR11 bacteria are crucial hosts for this viral group. In summary, our findings substantially expand current knowledge regarding the phylogenetic diversity, evolution, and distribution of HMO-2011-type phages, highlighting HMO-2011-type phages as major ecological agents that can infect certain key bacterial groups.
MicroRNAs as biomarkers for prostate cancer prognosis: a systematic review and a systematic reanalysis of public data
Authors: Rana Sharmila , Valbuena Gabriel N. , Curry Ed , Bevan Charlotte L. , Keun Hector C.
Published: January 2022

Background

Reliable prognostic biomarkers to distinguish indolent from aggressive prostate cancer (PCa) are lacking. Many studies investigated microRNAs (miRs) as PCa prognostic biomarkers, often reporting inconsistent findings. We present a systematic review of these; also systematic reanalysis of public miR-profile datasets to identify tissue-derived miRs prognostic of biochemical recurrence (BCR) in patients undergoing radical prostatectomy.

Methods

Independent PubMed searches were performed for relevant articles from January 2007 to December 2019. For the review, 128 studies were included. Pooled-hazard-ratios (HRs) for miRs in multiple studies were calculated using a random-effects model (REM). For the reanalysis, five studies were included and Cox proportional-hazard models, testing miR association with BCR, performed for miRs profiled in all.

Results

Systematic review identified 120 miRs as prognostic. Five (let-7b-5p, miR-145-5p, miR152-3p, miR-195-5p, miR-224-5p) were consistently associated with progression in multiple cohorts/studies. In the reanalysis, ten (let-7a-5p, miR-148a-3p, miR-203a-3p, miR-26b-5p, miR30a-3p, miR-30c-5p, miR-30e-3p, miR-374a-5p, miR-425-3p, miR-582-5p) were significantly prognostic of BCR. Of these, miR-148a-3p (HR = 0.80/95% CI = 0.68-0.94) and miR-582-5p (HR = 0.73/95% CI = 0.61-0.87) were also reported in prior publication(s) in the review.

Conclusions

Fifteen miRs were consistently associated with disease progression in multiple publications or datasets. Further research into their biological roles is warranted to support investigations into their performance as prognostic PCa biomarkers.
Optimizing the colorectal cancer screening programme using faecal immunochemical test (FIT) in Flanders, Belgium from the “interval cancer” perspective
Authors: Tran Thuy Ngan , Peeters Marc , Hoeck Sarah , Van Hal Guido , Janssens Sharon , De Schutter Harlinde
Published: January 2022

Background

Interval cancer (IC) is a critical issue in colorectal cancer (CRC) screening. We identified factors associated with ICs after faecal immunochemical test (FIT) screening and explored the impact of lowering FIT cut-off or shortening screening interval on FIT-ICs in Flanders.

Methods

FIT participants diagnosed with a CRC during 2013–2018 were included. Factors associated with FIT-ICs were identified using logistic regression. Distributions of FIT results among FIT-ICs were examined.

Results

In total, 10,122 screen-detected CRCs and 1534 FIT-ICs were included (FIT-IC proportion of 13%). FIT-ICs occurred more frequently in women (OR 1.58 [95% CI 1.41–1.76]) and ages 70–74 (OR 1.35 [1.14–1.59]). FIT-ICs were more often right-sided (OR 3.53 [2.98–4.20]), advanced stage (stage IV: OR 7.15 [5.76–8.88]), and high grade (poorly/undifferentiated: OR 2.57 [2.08–3.18]). The majority (83–92%) of FIT-ICs would still be missed if FIT cut-off was lowered from 15 to 10 µg Hb/g or screening interval was shortened from 2 to 1 year.

Conclusions

FIT-ICs were more common in women, older age, right-sided location, advanced stage and high grade. In Flanders, lowering FIT cut-off (to 10 µg Hb/g) or shortening screening interval (to 1 year) would have a minimal impact on FIT-ICs.
CircRNA circTIAM1 promotes papillary thyroid cancer progression through the miR-646/HNRNPA1 signaling pathway
Authors: Zhang Deguang , Tao Li , Xu Nizheng , Lu Xiaoxiao , Wang Jianle , He Gaofei , Tang Qinghu , Huang Kangmao , Shen Shuying , Chu Junjie
Published: January 2022

Papillary thyroid cancer (PTC) is a common endocrine tumor with a rapidly increasing incidence in recent years. Although the majority of PTCs are relatively indolent and have a good prognosis, a certain proportion is highly aggressive with lymphatic metastasis, iodine resistance, and easy recurrence. Circular RNAs (circRNAs) are a class of noncoding RNAs that are linked to a variety of tumor processes in several cancers, including PTC. In the current study, circRNA high-throughput sequencing was performed to identify alterations in circRNA expression levels in PTC tissues. circTIAM1 was then selected because of its increased expression in PTC and association with apoptosis, proliferation, and migration of PTC cells in vitro and in vivo. Mechanistically, circTIAM1 acted as a sponge of microRNA-646 and functioned in PTC by targeting miR-646 and heterogeneous ribonucleoprotein A1. Fluorescence in situ hybridization and dual-luciferase reporter assays further confirmed these connections. Overall, our results reveal an important oncogenic role of circTIAM1 in PTC and may represent a potentially therapeutic target against PTC progression.
Comparative effects of high pressure processing and heat treatment on in vitro digestibility of pea protein and starch
Authors: Hall Alexandra E. , Moraru Carmen I.
Published: January 2022

The effects of high-pressure processing (HPP) and heat treatment on the digestibility of protein and starch in pea protein concentrate (PPC) were investigated. Samples of PPC with 5% (5 P) and 15% (15 P) protein were treated by HPP (600 MPa/5 °C/4 min) or heat (95 °C/15 min) and their in vitro static and dynamic digestibility were compared to untreated controls. HPP-treated PPC underwent a greater degree of proteolysis and showed different peptide patterns after static gastric digestion compared to untreated and heat-treated PPC. Differences in protein digestibility among treatments during dynamic digestion were only significant (p < 0.05) during the first 20 min of jejunal, ileal, and total digestion for 5 P, and during the first 60 min of ileal digestion for 15 P. Neither static nor dynamic starch digestibility were dependent on treatment. HPP did not reduce trypsin inhibitor activity, whereas heat treatment reduced it by ~70%. HPP-induced structural modifications of proteins and starch did not affect their overall in vitro digestibility but enhanced gastric proteolysis.
Flipping food during grilling tasks, a dataset of utensils kinematics and dynamics, food pose and subject gaze
Authors: Pereira Débora , De Pra Yuri , Tiberi Emidio , Monaco Vito , Dario Paolo , Ciuti Gastone
Published: January 2022

This paper presents a multivariate dataset of 2866 food flipping movements, performed by 4 chefs and 5 home cooks, with different grilled food and two utensils (spatula and tweezers). The 3D trajectories of strategic points in the utensils were tracked using optoelectronic motion capture. The pinching force of the tweezers, the bending force and torsion torque of the spatula were also recorded, as well as videos and the subject gaze. These data were collected using a custom experimental setup that allowed the execution of flipping movements with freshly cooked food, without having the sensors near the dangerous cooking area. Complementary, the 2D position of food was computed from the videos. The action of flipping food is, indeed, gaining the attention of both researchers and manufacturers of foodservice technology. The reported dataset contains valuable measurements (1) to characterize and model flipping movements as performed by humans, (2) to develop bio-inspired methods to control a cooking robot, or (3) to study new algorithms for human actions recognition.
Aortic valve repair for the treatment of rheumatic aortic valve disease: a systematic review and meta-analysis
Authors: Zhao Meng , Tang Yihu , Li Luo , Dai Yawei , Lu Jieyu , Liu Xiang , Zhou Jingxin , Wu Yanhu
Published: January 2022

Valvuloplasty for rheumatic aortic valve disease remains controversial. We conducted this study to explore whether aortic valvuloplasty is appropriate for the rheumatic population. A comprehensive search was conducted, and 7 eligible retrospective studies were identified from PubMed, Embase, Medline and Cochrane (up to April 7, 2020) according to the inclusion and exclusion criteria. The data for hospital mortality, 5-year survival, 5-year reoperation, aortic insufficiency grade (AIG) and aortic valve gradient (AVG) were extracted by 2 independent reviewers and were analysed to evaluate the safety and availability of aortic valvuloplasty for rheumatic patients. The heterogeneity of the results was estimated using the Q test and I2 statistics. The fixed pooling model was used when I2 ≤ 50%; otherwise, the random pooling model was selected. 7 articles with 418 patients were included. The pooled hospital mortality, 5-year survival and 5-year reoperation rates were 3.2%, 94.5% and 9.9%, respectively. The heterogeneities of the weighted mean differences (WMD) values of the AIG and AVG between preoperation and postoperation were extremely high (I2 = 81.5%, p < 0.001 in AIG, I2 = 97.6%, p = 0.003 in AVG). Subgroup analysis suggested that the AIG and AVG were improved by 3.03 grades (I2 = 0%, p < 0.001) and 3.16 mmHg (I2 = 0%, p < 0.001) in the European group, respectively. In the Asian group, the AIG and AVG were improved by 2.57 grades (I2 = 0%, p < 0.001) and 34.39 mmHg (I2 = 0%, p < 0.001), respectively. Compared with the values at discharge, the AIG was increased by 0.15 grades (I2 = 0%, p = 0.031) and the AVG was still decreased by 2.07 mmHg (I2 = 0%, p = 0.031) at the time of follow up. Valvuloplasty is safe and effective to treat rheumatic aortic insufficiency and stenosis, and the duration of maintenance required to improve stenosis was longer than that of insufficiency.
Recruitment of a long-term memory supporting neural network during repeated maintenance of a multi-item abstract visual image in working memory
Authors: Heinen Klaartje T. H. , Kenemans J. Leon , van der Stigchel Stefan
Published: January 2022

Humans can flexibly transfer information between different memory systems. Information in visual working memory (VWM) can for instance be stored in long-term memory (LTM). Conversely, information can be retrieved from LTM and temporarily held in WM when needed. It has previously been suggested that a neural transition from parietal- to midfrontal activity during repeated visual search reflects transfer of information from WM to LTM. Whether this neural transition indeed reflects consolidation and is also observed when memorizing a rich visual scene (rather than responding to a single target), is not known. To investigate this, we employed an EEG paradigm, in which abstract six-item colour-arrays were repeatedly memorized and explicitly visualized, or merely attended to. Importantly, we tested the functional significance of a potential neural shift for longer-term consolidation in a subsequent recognition task. Our results show a gradually enhanced- and sustained modulation of the midfrontal P170 component and a decline in parietal CDA, during repeated WM maintenance. Improved recollection/visualization of memoranda upon WM-cueing, was associated with contralateral parietal- and right temporal activity. Importantly, only colour-arrays previously held in WM, induced a greater midfrontal P170-response, together with left temporal- and late centro-parietal activity, upon re-exposure. These findings provide evidence for recruitment of an LTM-supporting neural network which facilitates visual WM maintenance.
Torula yeast in the diet of Atlantic salmon Salmo salar and the impact on growth performance and gut microbiome
Authors: Leeper Alexandra , Ekmay Ricardo , Knobloch Stephen , Skírnisdóttir Sigurlaug , Varunjikar Madhushri , Dubois Marianne , Smárason Birgir Örn , Árnason Jón , Koppe Wolfgang , Benhaïm David
Published: January 2022

Atlantic salmon aquaculture is expanding, and with it, the need to find suitable replacements for conventional protein sources used in formulated feeds. Torula yeast (Cyberlindnera jadinii), has been identified as a promising alternative protein for feed and can be sustainably cultivated on lignocellulosic biomasses. The present study investigated the impact of torula yeast on the growth performance and gut microbiome of freshwater Atlantic salmon. A marine protein base diet and a mixed marine and plant protein base diet were tested, where conventional proteins were replaced with increasing inclusion levels of torula yeast, (0%, 10%, 20%). This study demonstrated that 20% torula yeast can replace fish meal without alteration to growth performance while leading to potential benefits for the gut microbiome by increasing the presence of bacteria positively associated with the host. However, when torula yeast replaced plant meal in a mixed protein diet, results suggested that 10% inclusion of yeast produced the best growth performance results but at the 20% inclusion level of yeast, potentially negative changes were observed in the gut microbial community, such as a decrease in lactic acid bacteria. This study supports the continued investigation of torula yeast for Atlantic salmon as a partial replacement for conventional proteins.
Proprioception and neuromuscular control at return to sport after ankle surgery with the modified Broström procedure
Authors: Lee Jin Hyuck , Jung Hae Woon , Jang Woo Young
Published: January 2022

The modified Broström procedure (MBP) is an initial treatment for symptomatic chronic ankle instability (CAI) patients. This study aimed to compare the proprioception and neuromuscular control ability of both affected and unaffected ankles at the time of return to sports after MBP for patients with scores of normal controls. 75 individuals (40 who underwent MBP, 35 normal controls) participated. The dynamic balance test scores were significantly higher in the affected ankle of the patients than in the controls (1.5 ± 0.6° vs. 1.1 ± 0.4°, p < 0.003). The time to peak torque for dorsiflexion (60.8 ± 13.9 ms vs. 52.2 ± 17.5 ms, p < 0.022) and eversion (68.9 ± 19.1 ms vs. 59.3 ± 21.1 ms, p < 0.043) was significantly delayed in the affected ankle of the patients than in the controls. The dynamic balance test and time to peak torque in CAI patients remained significantly reduced at the time of return-to-sport after MBP. Clinicians and therapists should be aware of potential deficits in proprioception and neuromuscular control when determining the timing of return to sports after MBP.
Annexin A6 and NPC1 regulate LDL-inducible cell migration and distribution of focal adhesions
Authors: Jose Jaimy , Hoque Monira , Engel Johanna , Beevi Syed S. , Wahba Mohamed , Georgieva Mariya Ilieva , Murphy Kendelle J. , Hughes William E. , Cochran Blake J. , Lu Albert , Tebar Francesc , Hoy Andrew J. , Timpson Paul , Rye Kerry-Anne , Enrich Carlos , Rentero Carles , Grewal Thomas
Published: January 2022

Cholesterol is considered indispensable for cell motility, but how physiological cholesterol pools enable cells to move forward remains to be clarified. The majority of cells obtain cholesterol from the uptake of Low-Density lipoproteins (LDL) and here we demonstrate that LDL stimulates A431 squamous epithelial carcinoma and Chinese hamster ovary (CHO) cell migration and invasion. LDL also potentiated epidermal growth factor (EGF) -stimulated A431 cell migration as well as A431 invasion in 3-dimensional environments, using organotypic assays. Blocking cholesterol export from late endosomes (LE), using Niemann Pick Type C1 (NPC1) mutant cells, pharmacological NPC1 inhibition or overexpression of the annexin A6 (AnxA6) scaffold protein, compromised LDL-inducible migration and invasion. Nevertheless, NPC1 mutant cells established focal adhesions (FA) that contain activated focal adhesion kinase (pY397FAK, pY861FAK), vinculin and paxillin. Compared to controls, NPC1 mutants display increased FA numbers throughout the cell body, but lack LDL-inducible FA formation at cell edges. Strikingly, AnxA6 depletion in NPC1 mutant cells, which restores late endosomal cholesterol export in these cells, increases their cell motility and association of the cholesterol biosensor D4H with active FAK at cell edges, indicating that AnxA6-regulated transport routes contribute to cholesterol delivery to FA structures, thereby improving NPC1 mutant cell migratory behaviour.
Machine learning algorithms as new screening approach for patients with endometriosis
Authors: Bendifallah Sofiane , Puchar Anne , Suisse Stéphane , Delbos Léa , Poilblanc Mathieu , Descamps Philippe , Golfier Francois , Touboul Cyril , Dabi Yohann , Daraï Emile
Published: January 2022

Endometriosis—a systemic and chronic condition occurring in women of childbearing age—is a highly enigmatic disease with unresolved questions. While multiple biomarkers, genomic analysis, questionnaires, and imaging techniques have been advocated as screening and triage tests for endometriosis to replace diagnostic laparoscopy, none have been implemented routinely in clinical practice. We investigated the use of machine learning algorithms (MLA) in the diagnosis and screening of endometriosis based on 16 key clinical and patient-based symptom features. The sensitivity, specificity, F1-score and AUCs of the MLA to diagnose endometriosis in the training and validation sets varied from 0.82 to 1, 0–0.8, 0–0.88, 0.5–0.89, and from 0.91 to 0.95, 0.66–0.92, 0.77–0.92, respectively. Our data suggest that MLA could be a promising screening test for general practitioners, gynecologists, and other front-line health care providers. Introducing MLA in this setting represents a paradigm change in clinical practice as it could replace diagnostic laparoscopy. Furthermore, this patient-based screening tool empowers patients with endometriosis to self-identify potential symptoms and initiate dialogue with physicians about diagnosis and treatment, and hence contribute to shared decision making.
Intraoperative hyperspectral imaging (HSI) as a new diagnostic tool for the detection of cartilage degeneration
Authors: Kistler Max , Köhler Hannes , Theopold Jan , Gockel Ines , Roth Andreas , Hepp Pierre , Osterhoff Georg
Published: January 2022

To investigate, whether hyperspectral imaging (HSI) is able to reliably differentiate between healthy and damaged cartilage tissue. A prospective diagnostic study was performed including 21 patients undergoing open knee surgery. HSI data were acquired during surgery, and the joint surface’s cartilage was assessed according to the ICRS cartilage injury score. The HSI system records light spectra from 500 to 1000 nm and generates several parameters including tissue water index (TWI) and the absorbance at 960 nm and 540 nm. Receiver operating characteristic curves were calculated to assess test parameters for threshold values of HSI. Areas with a cartilage defect ICRS grade ≥ 3 showed a significantly lower TWI (p = 0.026) and higher values for 540 nm (p < 0.001). No difference was seen for 960 nm (p = 0.244). For a threshold of 540 nm > 0.74, a cartilage defect ICRS grade ≥ 3 could be detected with a sensitivity of 0.81 and a specificity of 0.81. TWI was not suitable for cartilage defect detection. HSI can provide reliable parameters to differentiate healthy and damaged cartilage. Our data clearly suggest that the difference in absorbance at 540 nm would be the best parameter to achieve accurate identification of damaged cartilage.
Combining higher accumulation of amylopectin, lysine and tryptophan in maize hybrids through genomics-assisted stacking of waxy1 and opaque2 genes
Authors: Talukder Zahirul A. , Muthusamy Vignesh , Chhabra Rashmi , Gain Nisrita , Reddappa Shashidhar B. , Mishra Subhra J. , Kasana Ravindra , Bhatt Vinay , Chand Gulab , Katral Ashvinkumar , Mehta Brijesh K. , Guleria Satish K. , Zunjare Rajkumar U. , Hossain Firoz
Published: January 2022

Waxy maize rich in amylopectin has emerged as a preferred food. However, waxy maize is poor in lysine and tryptophan, deficiency of which cause severe health problems. So far, no waxy hybrid with high lysine and tryptophan has been developed and commercialized. Here, we combined recessive waxy1 (wx1) and opaque2 (o2) genes in the parental lines of four popular hybrids (HQPM1, HQPM4, HQPM5, and HQPM7) using genomics-assisted breeding. The gene-based markers, wx-2507F/RG and phi057 specific for wx1 and o2, respectively were successfully used to genotype BC1F1, BC2F1 and BC2F2 populations. Background selection with > 100 SSRs resulted in recovering > 94% of the recurrent parent genome. The reconstituted hybrids showed 1.4-fold increase in amylopectin (mean: 98.84%) compared to the original hybrids (mean: 72.45%). The reconstituted hybrids also showed 14.3% and 14.6% increase in lysine (mean: 0.384%) and tryptophan (mean: 0.102%), respectively over the original hybrids (lysine: 0.336%, tryptophan: 0.089%). Reconstituted hybrids also possessed similar grain yield (mean: 6248 kg/ha) with their original versions (mean: 6111 kg/ha). The waxy hybrids with high lysine and tryptophan assume great significance in alleviating malnutrition through sustainable and cost-effective means. This is the first report of development of lysine and tryptophan rich waxy hybrids using genomics-assisted selection.
High glycemic albumin representing prestroke glycemic variability is associated with hemorrhagic transformation in patients receiving intravenous thrombolysis
Authors: Lee Sang-Hwa , Jang Min Uk , Kim Yerim , Park So Young , Kim Chulho , Kim Yeo Jin , Sohn Jong-Hee
Published: January 2022

We evaluated the impact of prestroke glycemic variability estimated by glycated albumin (GA) on symptomatic hemorrhagic transformation (SHT) in patients with intravenous thrombolysis (IVT). Using a multicenter database, we consecutively enrolled acute ischemic stroke patients receiving IVT. A total of 378 patients were included in this study. Higher GA was defined as GA ≥ 16.0%. The primary outcome measure was SHT. Multivariate regression analysis and a receiver operating characteristic curve were used to assess risks and predictive ability for SHT. Among the 378 patients who were enrolled in this study, 27 patients (7.1%) had SHT as defined by the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SHTSITS). The rate of SHTSITS was higher in the higher GA group than in the lower GA group (18.0% vs. 1.6%, p < 0.001). A higher GA level (GA ≥ 16.0%) significantly increased the risk of SHTSITS (adjusted odds ratio [OR], [95% confidence interval, CI], 12.57 [3.08–41.54]) in the logistic regression analysis. The predictive ability of the GA level for SHTSITS was good (AUC [95% CI]: 0.83 [0.77–0.90], p < 0.001), and the cutoff value of GA in SHT was 16.3%. GA was a reliable predictor of SHT after IVT in acute ischemic stroke in this study.
Increased occurrence of high impact compound events under climate change
Authors: Ridder N. N. , Ukkola A. M. , Pitman A. J. , Perkins-Kirkpatrick S. E.
Published: January 2022

While compound weather and climate events (CEs) can lead to significant socioeconomic consequences, their response to climate change is mostly unexplored. We report the first multi-model assessment of future changes in return periods for the co-occurrence of heatwaves and drought, and extreme winds and precipitation based on the Coupled Model Intercomparison Project (CMIP6) and three emission scenarios. Extreme winds and precipitation CEs occur more frequently in many regions, particularly under higher emissions. Heatwaves and drought occur more frequently everywhere under all emission scenarios examined. For each CMIP6 model, we derive a skill score for simulating CEs. Models with higher skill in simulating historical CEs project smaller increases in the number of heatwaves and drought in Eurasia, but larger numbers of strong winds and heavy precipitation CEs everywhere for all emission scenarios. This result is partly masked if the whole CMIP6 ensemble is used, pointing to the considerable value in further improvements in climate models.
Zero-field skyrmionic states and in-field edge-skyrmions induced by boundary tuning
Authors: Spethmann Jonas , Vedmedenko Elena Y. , Wiesendanger Roland , Kubetzka André , von Bergmann Kirsten
Published: January 2022

When magnetic skyrmions are moved via currents, they do not strictly travel along the path of the current, instead their motion also gains a transverse component. This so-called skyrmion Hall effect can be detrimental in potential skyrmion devices because it drives skyrmions towards the edge of their hosting material where they face potential annihilation. Here we experimentally modify a skyrmion model system—an atomic Pd/Fe bilayer on Ir(111)—by decorating the film edge with ferromagnetic Co/Fe patches. Employing spin-polarized scanning tunneling microscopy, we demonstrate that this ferromagnetic rim prevents skyrmion annihilation at the film edge and stabilizes skyrmions and target states in zero field. Furthermore, in an external magnetic field the Co/Fe rim can give rise to skyrmions pinned to the film edge. Spin dynamics simulations reveal how a combination of different attractive and repulsive skyrmion-edge interactions can induce such an edge-pinning effect for skyrmions.
Tracking the time evolution of soft matter systems via topological structural heterogeneity
Authors: Membrillo Solis Ingrid , Orlova Tetiana , Bednarska Karolina , Lesiak Piotr , Woliński Tomasz R. , D’Alessandro Giampaolo , Brodzki Jacek , Kaczmarek Malgosia
Published: January 2022

Persistent homology is an effective topological data analysis tool to quantify the structural and morphological features of soft materials, but so far it has not been used to characterise the dynamical behaviour of complex soft matter systems. Here, we introduce structural heterogeneity, a topological characteristic for semi-ordered materials that captures their degree of organisation at a mesoscopic level and tracks their time-evolution, ultimately detecting the order-disorder transition at the microscopic scale. We show that structural heterogeneity tracks structural changes in a liquid crystal nanocomposite, reveals the effect of confined geometry on the nematic-isotropic and isotropic-nematic phase transitions, and uncovers physical differences between these two processes. The system used in this work is representative of a class of composite nanomaterials, partially ordered and with complex structural and physical behaviour, where their precise characterisation poses significant challenges. Our developed analytic framework can provide both a qualitative and quantitative characterisation of the dynamical behaviour of a wide range of semi-ordered soft matter systems.