bluuebunny/crossref_metadata_2025 huggingface dataset:
Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance
Authors: Mandt Rebecca EK , Luth Madeline R , Tye Mark A , Mazitschek Ralph , Ottilie Sabine , Winzeler Elizabeth A , Lafuente-Monasterio Maria Jose , Gamo Francisco Javier , Wirth Dyann F , Lukens Amanda K
Published: September 2023

Drug resistance remains a major obstacle to malaria control and eradication efforts, necessitating the development of novel therapeutic strategies to treat this disease. Drug combinations based on collateral sensitivity, wherein resistance to one drug causes increased sensitivity to the partner drug, have been proposed as an evolutionary strategy to suppress the emergence of resistance in pathogen populations. In this study, we explore collateral sensitivity between compounds targeting the Plasmodium dihydroorotate dehydrogenase (DHODH). We profiled the cross-resistance and collateral sensitivity phenotypes of several DHODH mutant lines to a diverse panel of DHODH inhibitors. We focus on one compound, TCMDC-125334, which was active against all mutant lines tested, including the DHODH C276Y line, which arose in selections with the clinical candidate DSM265. In six selections with TCMDC-125334, the most common mechanism of resistance to this compound was copy number variation of the dhodh locus, although we did identify one mutation, DHODH I263S, which conferred resistance to TCMDC-125334 but not DSM265. We found that selection of the DHODH C276Y mutant with TCMDC-125334 yielded additional genetic changes in the dhodh locus. These double mutant parasites exhibited decreased sensitivity to TCMDC-125334 and were highly resistant to DSM265. Finally, we tested whether collateral sensitivity could be exploited to suppress the emergence of resistance in the context of combination treatment by exposing wildtype parasites to both DSM265 and TCMDC-125334 simultaneously. This selected for parasites with a DHODH V532A mutation which were cross-resistant to both compounds and were as fit as the wildtype parent in vitro. The emergence of these cross-resistant, evolutionarily fit parasites highlights the mutational flexibility of the DHODH enzyme.
CRB3 navigates Rab11 trafficking vesicles to promote γTuRC assembly during ciliogenesis
Authors: Wang Bo , Liang Zheyong , Tan Tan , Zhang Miao , Jiang Yina , Shang Yangyang , Gao Xiaoqian , Song Shaoran , Wang Ruiqi , Chen He , Liu Jie , Li Juan , Ren Yu , Liu Peijun
Published: September 2023

The primary cilium plays important roles in regulating cell differentiation, signal transduction, and tissue organization. Dysfunction of the primary cilium can lead to ciliopathies and cancer. The formation and organization of the primary cilium are highly associated with cell polarity proteins, such as the apical polarity protein CRB3. However, the molecular mechanisms by which CRB3 regulates ciliogenesis and the location of CRB3 remain unknown. Here, we show that CRB3, as a navigator, regulates vesicle trafficking in γ-tubulin ring complex (γTuRC) assembly during ciliogenesis and cilium-related Hh and Wnt signaling pathways in tumorigenesis. Crb3 knockout mice display severe defects of the primary cilium in the mammary ductal lumen and renal tubule, while mammary epithelial-specific Crb3 knockout mice exhibit the promotion of ductal epithelial hyperplasia and tumorigenesis. CRB3 is essential for lumen formation and ciliary assembly in the mammary epithelium. We demonstrate that CRB3 localizes to the basal body and that CRB3 trafficking is mediated by Rab11-positive endosomes. Significantly, CRB3 interacts with Rab11 to navigate GCP6/Rab11 trafficking vesicles to CEP290, resulting in intact γTuRC assembly. In addition, CRB3-depleted cells are unresponsive to the activation of the Hh signaling pathway, while CRB3 regulates the Wnt signaling pathway. Therefore, our studies reveal the molecular mechanisms by which CRB3 recognizes Rab11-positive endosomes to facilitate ciliogenesis and regulates cilium-related signaling pathways in tumorigenesis.
Marvel Comics in the 1970s
Authors: Borenstein Eliot
Published: September 2023

This book explores a forgotten chapter in the story of the rise of comics as an art form. Bridging Marvel's dizzying innovations and the birth of the underground comics scene in the 1960s and the rise of the prestige graphic novel and postmodern superheroics in the 1980s, the book reveals a generation of comic book writers whose work at Marvel in the 1970s established their own authorial voice within the strictures of corporate comics. Through a diverse cast of heroes (and the occasional antihero)—Black Panther, Shang-Chi, Deathlok, Dracula, Killraven, Man-Thing, and Howard the Duck—writers such as Steve Gerber, Doug Moench, and Don McGregor made unprecedented strides in exploring their characters' inner lives. Visually, dynamic action was still essential, but the real excitement was taking place inside their heroes' heads. The book highlights the brilliant and sometimes gloriously imperfect creations that laid the groundwork for the medium's later artistic achievements and the broader acceptance of comic books in the cultural landscape today.
Untimely Sacrifices
Authors: Funahashi Daena Aki
Published: September 2023

This book questions why individuals may give their time and energy to the collective against their own self-interest. Turning to Finland where public health officials named occupational burnout as a “new hazard” of the new economy, the book asks: What moves people to work to the point of pathological stress? Contrary to health experts who highlight the importance of self-management and energetic conservation, the book questions the very economic premise of cognitive psychology that one could “economize” one's energy and thus save oneself. By pitting anthropological takes on sacrifice next to the clinical discourses on pressure, work, and coping, the book offers ways to rethink what drives stress. The book also provides a compelling critique of state welfare and political economy, contesting the tendency to treat the gift economy as something separate from the force that makes redistributive mechanisms of state welfare work. It is a book essential to those interested in how forces unassimilable to conventional economy come to matter in issues of labor, stress, and welfare.
The Education Myth
Authors: Shelton Jon
Published: September 2023

This book questions the idea that education represents the best, if not the only, way for Americans to access economic opportunity. As the author shows, linking education to economic well-being was not politically inevitable. In the eighteenth and nineteenth centuries, for instance, public education was championed as a way to help citizens learn how to participate in a democracy. By the 1930s, public education, along with union rights and social security, formed an important component of a broad-based fight for social democracy. The book demonstrates that beginning in the 1960s, the political power of the education myth choked off powerful social democratic alternatives. The nation's political center was bereft of any realistic ideas to guarantee economic security and social dignity for the majority of Americans, particularly those without college degrees. Embraced first by Democrats like Lyndon Johnson, Jimmy Carter, and Bill Clinton, Republicans like George W. Bush also pushed the education myth. The result, over the past four decades, has been the emergence of a deeply inequitable economy and a drastically divided political system.
Judgment and Mercy
Authors: Siegel Martin J.
Published: September 2023

This book offers an insightful and compelling biography of Irving Robert Kaufman, the judge infamous for condemning Julius and Ethel Rosenberg to death for atomic espionage. In 1951, world attention fixed on Kaufman's courtroom as its ambitious young occupant stridently blamed the Rosenbergs for the Korean War. To many, the harsh sentences and their preening author left an enduring stain on American justice. But then the judge from Cold War central casting became something unexpected: one of the most illustrious progressive jurists of his day. Upending the simplistic portrait of Judge Kaufman as a McCarthyite villain, the book shows how his pathbreaking decisions desegregated a Northern school for the first time, liberalized the insanity defense, reformed Attica-era prisons, spared John Lennon from politically motivated deportation, expanded free speech, brought foreign torturers to justice, and more. Still, the Rosenberg controversy lingered. Decades later, changing times and revelations of judicial misconduct put Kaufman back under siege. Picketers dogged his footsteps as critics demanded impeachment. And tragedy stalked his family, attributed in part to the long ordeal. Instead of propelling him to the Supreme Court, as Kaufman once hoped, the case haunted him to the end. The book brings to life a complex man by turns tyrannical and warm, paranoid and altruistic, while revealing intramural Jewish battles over assimilation, class, and patriotism. The author, who served as Kaufman's last law clerk, traces the evolution of American law and politics in the twentieth century and shows how a judge unable to summon mercy for the Rosenbergs nonetheless helped expand freedom for all.
An Environmental Leader's Tool Kit
Authors: Hughes Jeffrey W.
Published: September 2023

For anyone wanting to tackle an environmental problem in their neighborhood but do not know where to start, this book can help. In this handbook, the author shares proven strategies needed to step up and get meaningful action done. From designing a pilot study to managing contentious public meetings and more, the author walks the reader through the essentials of effective place-based environmental efforts. Among the tools found here are worksheets to kickstart brainstorming, appendixes that demystify jargon you might encounter, and illuminating, real-life examples. Down-to-earth and stimulating, the book is a launchpad for those ready to make a difference now.
The Closed Partisan Mind
Authors: Luttig Matthew D.
Published: September 2023

This book traces the roots of partisan polarization to psychological closed-mindedness in the electorate and the changing perception of politics created by polarized political leaders and the new media environment. American politics today can be defined by the intense and increasingly toxic divide between Democrats and Republicans. This book explores why so many Americans have endorsed this level of political conflict. The book illustrates how the psychological need for closure leads people, regardless of whether they identify as Democrat or Republican, to express more polarized political attitudes. This association between closed minds and partisan polarization is a new phenomenon and can be traced to broader changes in American society, such as the creation of ideologically distinct political parties and a fragmented media environment. These developments have simplified politics into a black-or-white, us-versus-them conflict—making politics appeal to those with closed minds. Today, strong partisans do not just cheer for their political party to win elections. Instead, more akin to religious true believers, strong partisans use their affiliation as a means of understanding right and wrong, friend and enemy, true and false. The book reveals that these dynamics have manifested in both a new type of partisanship and a new type of partisan. The emergence of this new closed partisanship illustrates the dangers that polarization has wrought on society, politics, and the minds of Americans.
Tamizdat
Authors: Klots Yasha
Published: September 2023

This book offers a new perspective on the history of the Cold War by exploring the story of the contraband manuscripts sent from the USSR to the West. A word that means publishing “over there,” tamizdat manuscripts were rejected, censored, or never submitted for publication in the Soviet Union and were smuggled through various channels and printed outside the country, with or without their authors' knowledge. This book demonstrates how tamizdat contributed to the formation of the twentieth-century Russian literary canon: the majority of contemporary Russian classics first appeared abroad long before they saw publication in Russia. Examining narratives of Stalinism and the Gulag, the book focuses on contraband manuscripts in the 1960s and 1970s, from Khrushchev's Thaw to Stagnation under Brezhnev. The book revisits the traditional notion of late Soviet culture as a binary opposition between the underground and official state publishing. It shows that even as tamizdat represented an alternative field of cultural production in opposition to the Soviet regime and the dogma of Socialist Realism, it was not devoid of its own hierarchy, ideological agenda, and even censorship. The book is a cultural history of Russian literature outside the Iron Curtain. The Russian literary diaspora was the indispensable ecosystem for these works. Yet in the post-Stalin years, they also served as a powerful weapon on the cultural fronts of the Cold War, laying bare the geographical, stylistic, and ideological rifts between two disparate yet inextricably intertwined fields of Russian literature, one at home, the other abroad.
A Diabolical Voice
Authors: Trombley Justine L.
Published: September 2023

This book traces the afterlife of The Mirror of Simple Souls, which circulated anonymously for two centuries in four languages, though not without controversy or condemnation. Widely recognized as one of the most unusual and important mystical treatises of the late Middle Ages, the Mirror was condemned in Paris in 1310 as a heretical work, and its author, Marguerite Porete, was burned at the stake. Alongside the work's increasing positive reception was a parallel trend of opposition and condemnation centered specifically around its Latin translation. The book introduces fourteenth-and fifteenth-century theologians, canon lawyers, inquisitors, and other churchmen who were entirely ignorant of the Mirror's author and its condemnation and saw in the work dangerous heresies that demanded refutation and condemnation of their own. It charts the range of negative reactions to the Mirror, from confiscations and physical destruction to academic refutations and vicious denunciations of its supposedly fiendish doctrines. This parallel story of opposition shows how heresy remained an integral part of the Mirror's history well beyond the events of 1310, revealing how seriously churchmen took Marguerite Porete's ideas on their own terms, in contexts entirely removed from Marguerite's identity and her fate. Emphasizing the complexity of The Mirror of Simple Souls and its reception, this work makes clear that this influential book continues to yield new perspectives and understandings.
Vanishing Point
Authors: Wilber Tom
Published: September 2023

This book pieces together the largely forgotten story of the bomber, Getaway Gertie, and an eclectic group of enthusiasts who have spent years searching for it. At the height of World War II, a B-24 Liberator bomber vanished with its crew while on a training mission over upstate New York. The final hours and ultimate resting place of pilot Keith Ponder and seven other US aviators aboard the plane remain mysteries to this day. The tale is at once a compelling instance of loss on the World War II American home front and a more extensive, largely unreported history. Ponder, a 21-year-old from rural Mississippi and his crew were tragically unexceptional casualties in the monumental effort to recruit and train an air force en masse to counter the global conquest of Nazi Germany and Imperial Japan. More than fifteen thousand American airmen and, in some cases, women burned, crashed, or fell to their deaths in stateside training accidents during the war—their lives and stories shuffled away in piles of Air Force bureaucracy. The forgotten story of Getaway Gertie was originally inspired by summer evenings around the campfire on the shores of Lake Ontario, where parts of the plane have washed up. Building on those campfire tales, the book deftly connects myth with fact and memory with historicity. The result is a vivid portrait of the forgotten soldier of the home front and a new take on the meaning of wartime sacrifice as the last survivors of the Greatest Generation pass away.
A lightweight intrusion detection method for IoT based on deep learning and dynamic quantization
Authors: Wang Zhendong , Chen Hui , Yang Shuxin , Luo Xiao , Li Dahai , Wang Junling
Published: September 2023

Intrusion detection ensures that IoT can protect itself against malicious intrusions in extensive and intricate network traffic data. In recent years, deep learning has been extensively and effectively employed in IoT intrusion detection. However, the limited computing power and storage space of IoT devices restrict the feasibility of deploying resource-intensive intrusion detection systems on them. This article introduces the DL-BiLSTM lightweight IoT intrusion detection model. By combining deep neural networks (DNNs) and bidirectional long short-term memory networks (BiLSTMs), the model enables nonlinear and bidirectional long-distance feature extraction of complex network information. This capability allows the system to capture complex patterns and behaviors related to cyber-attacks, thus enhancing detection performance. To address the resource constraints of IoT devices, the model utilizes the incremental principal component analysis (IPCA) algorithm for feature dimensionality reduction. Additionally, dynamic quantization is employed to trim the specified cell structure of the model, thereby reducing the computational burden on IoT devices while preserving accurate detection capability. The experimental results on the benchmark datasets CIC IDS2017, N-BaIoT, and CICIoT2023 demonstrate that DL-BiLSTM surpasses traditional deep learning models and cutting-edge detection techniques in terms of detection performance, while maintaining a lower model complexity.
Genome-wide analysis of the heat shock transcription factor family reveals saline-alkali stress responses in Xanthoceras sorbifolium
Authors: Li Lulu , Ju Yiqian , Zhang Cuiping , Tong Boqiang , Lu Yizeng , Xie Xiaoman , Li Wei
Published: September 2023

The heat shock transcription factor (HSF) family is involved in regulating growth, development, and abiotic stress. The characteristics and biological functions of HSF family member in X. sorbifolium, an important oil and ornamental plant, have never been reported. In this study, 21 XsHSF genes were identified from the genome of X. sorbifolium and named XsHSF1-XsHSF21 based on their chromosomal positions. Those genes were divided into three groups, A, B, and C, containing 12, one, and eight genes, respectively. Among them, 20 XsHSF genes are located on 11 chromosomes. Protein structure analysis suggested that XsHSF proteins were conserved, displaying typical DNA binding domains (DBD) and oligomerization domains (OD). Moreover, HSF proteins within the same group contain specific motifs, such as motif 5 in the HSFC group. All XsHSF genes have one intron in the CDS region, except XsHSF1 which has two introns. Promoter analysis revealed that in addition to defense and stress responsiveness elements, some promoters also contained a MYB binding site and elements involved in multiple hormones responsiveness and anaerobic induction. Duplication analysis revealed that XsHSF1 and XsHSF4 genes were segmentally duplicated while XsHSF2, XsHSF9, and XsHSF13 genes might have arisen from transposition. Expression pattern analysis of leaves and roots following salt-alkali treatment using qRT-PCR indicated that five XsHSF genes were upregulated and one XsHSF gene was downregulated in leaves upon NaCl treatment suggesting these genes may play important roles in salt response. Additionally, the expression levels of most XsHSFs were decreased in leaves and roots following alkali-induced stress, indicating that those XsHSFs may function as negative regulators in alkali tolerance. MicroRNA target site prediction indicated that 16 of the XsHSF genes may be regulated by multiple microRNAs, for example XsHSF2 might be regulated by miR156, miR394, miR395, miR408, miR7129, and miR854. And miR164 may effect the mRNA levels of XsHSF3 and XsHSF17, XsHSF9 gene may be regulated by miR172. The expression trends of miR172 and miR164 in leaves and roots on salt treatments were opposite to the expression trend of XsHSF9 and XsHSF3 genes, respectively. Promoter analysis showed that XsHSFs might be involved in light and hormone responses, plant development, as well as abiotic stress responses. Our results thus provide an overview of the HSF family in X. sorbifolium and lay a foundation for future functional studies to reveal its roles in saline-alkali response.
Secretariado Executivo e os Estereótipos de Gênero
Authors: Sousa Gabriel da Silva , De Melo Stella Maria Carvalho
Published: September 2023

Os estereótipos de gênero quando são direcionados a homens e mulheres podem ter efeitos negativos, especialmente em ambientes acadêmicos e profissionais. Nesses termos, o presente artigo teve como objetivo investigar a produção acadêmica atual sobre estereótipos de gênero no Secretariado. A metodologia, que consistiu em pesquisa bibliográfica e Revisão Sistemática de Literatura, utilizou-se de estudos em bases de dados nacionais, relacionados ao tema em questão. As bases de dados utilizadas foram: Google Acadêmico, periódicos CAPES e revistas eletrônicas de Secretariado, incluindo artigos publicados nos últimos 10 anos. Foram encontrados um total de 18 estudos de essencial relevância ao tema em questão, os quais foram submetidos a uma análise rigorosa. Ao decorrer da pesquisa foi constatado que a temática ainda é recente, o que indica a necessidade de novos estudos sobre o assunto. A influência da mídia na propagação desses estereótipos foi destacada expressivamente. A pesquisa conclui que os estereótipos de gênero têm um impacto significativo na binaridade de gênero (masculino e feminino), mas também em outras identidades de gênero e sexualidades não heteronormativas dentro da área de Secretariado. Pode-se concluir, também, que a permanência desses estereótipos pode influenciar na escolha dos estudantes e possíveis profissionais na área em relação ao curso e profissão.
Análise e reestruturação de layout no setor de pré-montagem da linha seriado em uma indústria moveleira
Authors: Trevisol Janyel
Published: September 2023

A busca constante em diminuir os custos operacionais, bem como o aumento da produtividade e a diminuição de problemas internos, tem sido o alvo das empresas para continuarem inseridas dentro de um mercado altamente competitivo. Para isso, mudanças internas fazem parte das estratégias para atingir tais objetivos. O presente trabalho tem como objetivo implementar um novo layout com otimização do espaço produtivo no setor de pré-montagem da linha seriado, em uma indústria moveleira. O método utilizado para a elaboração deste trabalho foi a pesquisa-ação, que possibilitou uma análise detalhada e permitiu-se a implementação de um novo layout, compatível com o processo de fabricação da empresa. Como resultados do trabalho, obteve-se clareza do processo, otimização do espaço físico, redução de movimentações e transportes de materiais, redução de estoque em processo, facilidade nos fluxos logísticos interno devido aos corredores bem dimensionados, melhor visibilidade do setor, organização e limpeza, controle produtivo mais eficiente e redução de desperdícios.
Indicações geográficas e suas contribuições para as políticas públicas regionais
Authors: Venâncio Maria Fernanda Daltro , Da Conceição Valdir Silva , Silva Daliane Teixeira , Piau Deise Danielle Neves , Araújo Marcio Luis Valença , Silva Marcelo Santana
Published: September 2023

No Brasil, a utilização formal da Indicação Geográfica (IG) é recente, sendo um tema relevante para as cadeias produtivas, as Instituições de Ensino e Pesquisa e o Poder Público, haja vista o grande potencial de diferentes produtos para esse tipo de registro, e principalmente pelos múltiplos benefícios desta ferramenta de proteção. Este estudo visa trazer reflexões sobre como a implementação das IGs podem contribuir com o fomento de Políticas Públicas Regionais, identificando potencialidades e vocações que tragam melhorias às comunidades locais. Metodologicamente, a pesquisa é qualitativa, de caráter bibliográfico exploratório e tem com foco principal a inter-relação entre Indicação Geográfica e Políticas Públicas Regionais. A eficácia das IGs é baseada em atividades gerenciais, comerciais, turísticas que devem estar interligadas com ações políticas e sociais. Assim, é necessário aliar os anseios da sociedade contemporânea à necessidade de salvaguardar tradições, preservar o meio ambiente e manter o tecido socioeconômico rural.
Bioactivity and antimicrobial evaluation of extracts from Chrysobalanus icaco L. found in the amazonian maranhense, Brazil
Authors: Nojosa Ellen Cristine Nogueira , Marques Georgiana Eurides de Carvalho , Da Paz Suzana dos Anjos , Reis Jhovanna Teixeira , Brandão Clenilma Marques , Do Nascimento Adriana Silva , Camara Marcos Bispo Pinheiro , Dos Santos Djanira Rubim
Published: September 2023

The Brazilian Amazon-cerrado transition regions harbor a rich native biodiversity used for food, conservation and medicinal purposes by traditional communities and with industrial interest. In this scenario, the present research aimed to analyze the presence of phenolic and chemical compounds and antimicrobial activity of the stem, leaf and fruit of Chrysobalanus icaco L. The methodology was based on the study of the leaves and fruits of the species through alcoholic and aqueous extracts for phytochemical screening, determination of the physicochemical composition, bioactive compounds, antioxidant activity and antimicrobial activity following specific methodologies. The phytochemical screening showed the presence of mainly phenolic compounds and flavonoids, with higher concentration in the leaves. In the chemical composition of the leaves the concentration of protein, mineral material, fiber and total carbohydrates stood out, while in the fruits fibers and mineral material. In the contents of bioactive compounds, the leaves also differ from the fruits by the superior amount for the same compounds, also when comparing with other species also prevails with higher concentration, as in the example of acerola. In the antioxidant activity, the leaves, due to their concentration of bioactive compounds, showed a greater capacity to sequester free radicals than the fruit, however, both have high antioxidant capacity when compared to other native Brazilian plants. In the antimicrobial activity, the tests showed promising for Salmonella 14026 (12.5 mg/mL), E. coli 042 (12.5 mg/mL) and S. aureus 6538 (6.25 mg/mL). Thus, the results presented in this research corroborate the food and medicinal use of both the leaves and fruits of C. icaco species, since they have antioxidant and biological activity to control bacteria.
Neurociências e educação: interferência das sinapses no processo de aprendizagem
Authors: Rodrigues Michele Aparecida Cerqueira , Barbosa Fernando Campos , Lopes Gabriel César Dias , Santacroce Luigì
Published: September 2023

A neurociência ajuda a desvendar a complexidade das sinapses cerebrais e demonstra como a neuroplasticidade influência na aprendizagem. O objetivo deste artigo é entender como as sinapses moldam nosso pensamento e quais estratégias educacionais podem otimizar essa interação. É fato que a plasticidade sináptica seja essencial neste processo, pois permite a formação de memória e aprendizado contínuo. Neste sentido, estratégias pedagógicas que envolvam os alunos, recursos multissensoriais e mindfulness enriquecem as conexões sinápticas e aprimoram a cognição. Além disso, a criação de um ambiente de aprendizagem positivo e inclusivo facilita a formação de sinapses sólidas. Portanto, compreender e explorar as sinapses oferece um caminho promissor para melhorar a educação e promover um aprendizado significativo ao longo da vida. A interação entre neurônios e sinapses é a base da cognição humana, e entendê-las pode revolucionar as formas de ensinar e aprender, criando uma sociedade mais educada e adaptável às demandas do mundo moderno.
Os benefícios e diferenciais da tecnologia BIM na construção civil
Authors: Miranda Gustavo Macedo , De Oliveira Danielle Meireles , Almeida Marys Lene Braga , Ribeiro Maria Carmen Couto , Ribeiro Sidnea Eliane Campos , Branco Luiz Antônio Melgaço Nunes
Published: September 2023

Na construção civil, a tecnologia Building Information Modelling (BIM) permitiu que as disciplinas que compõem os projetos, antes feitas de forma totalmente separada, passassem a ser projetadas de forma integrada em uma mesma ferramenta e, a partir disso, permitiu que se obtivessem retornos instantâneos para a melhoria dos projetos, maior agilidade e assertividade nos orçamentos. Dentro deste contexto, este trabalho avaliou os benefícios e diferenciais da tecnologia BIM com relação às ferramentas convencionais 2D por meio da modelagem de um empreendimento de pequeno porte. Assim, foi possível identificar, dentre outros, a precisão das tabelas de quantitativos geradas de forma automática, o ajuste instantâneo em todas as vistas sob qualquer alteração feita no projeto, a flexibilidade e versatilidade da ferramenta ao permitir criar projetos únicos, a facilidade de realizar ajustes que podem implicar em um orçamento mais assertivo com redução de desperdícios. Por fim, foi possível notar que a tecnologia BIM é capaz de melhorar a eficiência dos processos construtivos e pode ser um meio para que se faça melhor uso dos materiais.
Effect of Palonosetron in the Prevention of Spinal Anaesthesia-induced Hypotension and Bradycardia: A Randomised Controlled Trial
Authors: Pradeep Devulapalli Janardhana , Giri Sanjeeb Kumar , Mohapatra Partha Sarathi , Das Mousumi , Sahu Lingaraj
Published: September 2023

Introduction: Spinal Anaesthesia (SA) is frequently associated with hypotension, which is due to sympathectomy causing vasodilation, leading to relative hypovolemia. This decrease in venous return to the heart causes a decrease in left ventricular filling pressure, leading to the activation of the Bezold-Jarisch Reflex (BJR), which causes bradycardia. This response is mediated by mechanoreceptors and chemoreceptors present on the heart walls. These chemoreceptors are mediated through serotonin (5-HT). Therefore, the activation of 5-HT3 receptors at sensory vagal nerve endings in the heart causes hypotension and bradycardia. Aim: To assess the efficacy of Palonosetron in attenuating spinal anaesthesia-induced hypotension and bradycardia. Materials and Methods: The trial was a parallel-design, randomised, double-blind controlled trial conducted over two years, from February 2021 to August 2022 in the Department of Anaesthesiology, Kalinga Institution of Medical Sciences (KIMS), Bhubaneswar, Odisha, India, among patients undergoing spinal anaesthesia for various surgeries. The patients were divided into two groups based on the type of medication received: Group APalonosetron group and Group B- the saline group. Computergenerated random number generator software was used for randomisation. At a 1:1 ratio, 150 patients were chosen (75 in each group). Baseline assessment of haemodynamic parameters was performed, followed by continuous monitoring. The drug was administered 10 minutes prior to spinal anaesthesia, and the haemodynamic parameters (Heart Rate [HR], Systolic Blood Pressure [SBP], Diastolic Blood Pressure [DBP], and Mean Arterial Pressure [MAP]) were monitored. Continuous variables are expressed as mean±Standard Deviation (SD). The Student’s t-test was used to compare the difference between the two groups, and categorical variables are expressed as frequency and percentage, with comparisons done using the Chi-square test. A p-value of <0.05 was considered statistically significant. Results: The mean age of Group A and Group B was 40.88 and 42.14, respectively. Significant haemodynamic changes (hypotension) were observed following induction in Group B (28 [37.3%]) compared to Group A (9 [12%]). Consumption of vasopressors and intravenous (i.v.) fluids was significantly higher in Group B compared to Group A. The incidence of bradycardia in Group A and Group B was 15 (20%) and 18 (24%), respectively. Postoperative Nausea and Vomiting (PONV) in Group A and Group B were 3 (4%) and 8 (10.7%), respectively. Conclusion: Based on the present study, the prophylactic administration of 0.075 mg Palonosetron 10 minutes before subarachnoid block is effective in attenuating the incidence of spinal anaesthesia-induced hypotension and bradycardia. There is also decreased consumption of vasopressors and a lower incidence of PONV..
A Comprehensive Investigation of the Interactions between Proteins and Ligands in the Crystal Structures of Mycobacterium Tuberculosis
Authors: Nanaware Rajesh , Chabukswar Anuruddha , Tekade Vishal , Kashid Kunal , Vidhate Tejas , Karmure Rushikesh
Published: September 2023

Mycobacterium tuberculosis (MTB), an acid-fast aerobic bacterium that may grow on gram stain as either a gram-positive or gram-negative bacterium, is the disease-causing agent of tuberculosis (TB). Rifampin, isoniazid, pyrazinamide and ethambutol, the first-line anti-tubercular drugs, can all have hepatotoxic side effects. The new medicine needs to work through a novel mode of action or to a novel target, be more active than presently available treatments, and shorten the course of treatment for the MDR-TB and XDR-TB, also active against both active and latent bacteria, and does not interact with antiretroviral medications because many TB patients also have HIV. Additionally, it must work well with other anti-TB medications to form at least an effective three-drug regimen. This article discusses the analysis of a few FDA-approved anti-tubercular medications and their binding locations with respective targeted proteins. This mainly focuses on the amino acids of the proteins that are responsible for the formation of interactions with a drug molecule. So, researchers can modify the existing drugs or their derivatives or can construct a new molecule according to the binding sites of enzymes corresponding to mycobacterium tuberculosis.
Quality Evaluation and Economics of Gum Cluster Bean Genotypes under Akola Conditions
Authors: Narayanappa Deepa , Nagre P. K. , Wagh A. P. , Kale V. S. , Minz Alka
Published: September 2023

A field experiment was carried out in 2020-21 at Instructional Farm, Department of Vegetable Science, Dr. PDKV, Akola with the objective to find out superior genotype of cluster bean for its quality parameters and cost of production i.e., gum content (%), protein content (%), test weight (g) and economics respectively. The experiment was laid out in Randomized Block Design (RBD) with three replications and twelve treatments as genotypes. With respect to quality parameters, genotype IC-329639(T4) recorded maximum gum content (32.86 %), while maximum protein content (38.33 %) was found in genotype IC-298638(T8) and maximum (3.98 g) test weight in the genotype IC-421837(T7). Consequently, with regards to economics, highest gross returns (Rs 174000 ha-1), net returns (Rs 129137.7 ha-1) and B:C ratio (3.87) was recorded in the genotype IC-329639(T4).
Baby Corn-Based Intercropping System in Enhancing the Growth and Production of Winter Season Baby Corn in Chhattisgarh Plains
Authors: Mohan Minu , Khajanji S. N. , Pandey N.
Published: September 2023

An experiment was carried out during the winter season (rabi) for two years 2019-20 and 2020-21 on Instructional cum Research Farm, Indira Gandhi Krishi Vishwavidyalay, Raipur (C.G.) to enhance the production of baby corn through intercropping. The experiment was laid out in randomized block design (RBD) with eight treatment consisting of sole and paired row baby corn along with a combination of various legumes. The treatments were T1 : sole baby corn (45 x 20 cm), T2 : paired row baby corn (30/60 cm) T3 : sole fenugreek (30 x 10 cm), T4 : sole pea (30 x 20 cm), T5 : sole cowpea (30 x 20 cm) T6 : paired row baby corn + pea (2:2), T7 : paired row baby corn + fenugreek (2:2) and T8 : paired row baby corn + cowpea (2:2). The result of the experiment was concluded that growth attributes was highest under the treatment of T6: paired row baby corn + pea which was closely followed by T8: paired row baby corn + cowpea. Also, T6: paired row baby corn + pea maximized the baby corn cob and fodder yield and therefore pea proved to be a valuable intercrop with baby corn in enhancing the production of baby corn.
Exploring the Phosphate Solubilizing Potential and Acid-Alkaline Phosphatase Activity of Two Multitrait Heavy Metal Tolerant Bacterial Strains Isolated from North Gujarat, India
Authors: Yadav Anurag , Chaudhari Rinkalben , Soni Kavin , Yadav Kusum
Published: September 2023

A study was conducted to isolate and characterize phosphate solubilizing bacteria (PSB) from soils of various locations in North Gujarat. A total of 40 PSB isolates were obtained, exhibiting a phosphate solubilizing index (PSI) ranging from 2.11 to 4.33. Interestingly, among 40 PSB isolates, a subset of 16 displayed an additional trait of potassium solubilization, as evidenced by their potassium solubilizing index (KSI) values falling within the range of 2.10 to 3.10. These 16 PSB isolates were screened for tolerance to heavy metal stressors, namely CdCl2, HgCl2, Pb(NO3)2, and ZnSO4, spanning a concentration gradient from 0.1 mM to 10 mM. Remarkably, among the tested isolates, two, namely, D4 and G2, exhibited exceptional resilience against the heavy metal stressors, as indicated by their minimum inhibitory concentration (MIC). Specifically, isolate D4 showed MIC values of 5 mM, 0.2 mM, 18 mM, and 12 mM, respectively, against CdCl2, HgCl2, Pb(NO3)2, and ZnSO4. For isolate G2, the corresponding MIC values were 6 mM, 0.2 mM, 21 mM, and 11 mM. The bacterial isolates were molecularly identified as strains Klebsiella pneumoniae PHmD4 (abbreviated as D4) and Enterobacter chuandaensis PHmG2 (abbreviated as G2), based on sequence homology obtained from 16S rDNA gene sequencing and subsequent BLAST analysis. In Pikovskaya’s broth, K. pneumoniae PHmD4 and E. chuandaensis PHmG2 had phosphate solubilization values of 4.30 μ moles mL⁻¹ and 3.51 μmoles mL⁻¹, respectively, with terminal pH values of 3.06 and 4.07. Enzymatic activity assays conducted after 96 hours of incubation in Pikovskaya’s broth revealed that the highest acid phosphatase activity was 21.62 U mL⁻¹ for K. pneumoniae PHmD4 and 21.09 U mL⁻¹ for E. chuandaensis PHmG2. The highest alkaline phosphatase activity was 5.85 U mL⁻¹ and 6.38 U mL⁻¹, respectively. In the tomato seed germination study, both non-bacterized and bacterized tomato seeds achieved a 100% germination rate. However, increasing metal concentrations diminished the germination percentage of heavy metal-treated seeds. Interestingly, bacterization with K. pneumoniae PHmD4 and E. chuandaensis PHmG2 ameliorated germination under cadmium stress but had no mitigative effect under mercury and zinc stress conditions.
The Phenomenon of Laundry Industries in Indonesia
Authors: Atikah Azra , Lestari Nindya , Kurniawati Sri , Yacoub Yarlina , Dina Fara , Suharlina Helly
Published: September 2023

Aims: This study aims to analyze the effect of the use of technology, wages, and capital on employment in the laundry industry.

Study Design:  This study is a mix method of qualitative and quantitative research.

Place and Duration of Study: This sample is industry laundry in Pontianak City between January-June 2023

Methodology: This study shows the effect of capital, wages, amount of production, and technology on the absorption of labour in the laundry industry in Pontianak using a multiple regression model. This study used 60 samples of the laundry industry from the Pontianak City Trade Office. To get a complete phenomenon, further observations and in-depth interviews were carried out with the respondents.

Results: the results of the study show that changes in wages and technology have a significant effect on labour with a significance level of 5% and 10%, while changes in wages and production values have no significant effect on labour.

Conclusion: This research that capital and technology affect the number of workers in the research area. This shows that the addition of capital and technology will encourage an increase in the number of workers which will have an impact on increasing economic growth. This is due to the additional capital and technology that will be used to increase the number of equipment and consumables that will be used by the Company, including the addition of modes of transportation. This indicates the need for more workers so that production continues to increase.
The Tradeoff of Child Labor: Evidence from Indonesia
Authors: Mahendra Fiqih Yusril , Bariyah Nurul , Yani Akhmad , Wahyudi  , Yanto
Published: September 2023

Using data from the Indonesia Family Life Survey (IFLS), this study examines the influence of child labor on wages and educational attainment in Indonesia. Several statistical methods, such as Propensity Score Matching (PSM), Quantile Regression, and robust Ordinary Least Squares (OLS) models, are used to analyze the relationship between child labor, income, and education while controlling for confounding variables. The findings indicate that child labor is initially associated with reduced wages, but this association becomes insignificant when other variables, such as years of education, are considered. Longer educational periods mitigate the negative effects of child labor on wages. In addition, the analysis reveals a tradeoff between child labor and educational attainment, highlighting the impact of child labor on education. Access to economic resources, however, mitigates this tradeoff, highlighting the importance of economic factors in children's decision-making. The study highlights the significance of child protection measures and effective socioeconomic policies to guarantee children's access to education and enhance their opportunities. It provides valuable insights into the effects of child labor on education and the role of economic factors in determining how children allocate their time.
Kompetensi Komunikasi Antarbudaya dalam Pernikahan Pasangan Etnis Tionghoa dan Etnis Jawa di Kabupaten Jember
Authors: Halim Melinda Valentine
Published: September 2023

Pernikahan antaretnis Tionghoa-Jawa adalah sebuah fenomena yang menarik karena kedua etnis ini memiliki tingkat kolektivisme yang tinggi dalam hal pendirian moral, ideologi, filsafat politik, dan pandangan sosial. Hal ini menjadi sebuah tantangan besar, karena tidak mudah menyatukan dua orang dari latar belakang budaya berbeda ke dalam sebuah pernikahan. Perbedaan budaya terkadang dapat menjadi hambatan komunikasi, seperti mudah menimbulkan kesalahpahaman bahkan konflik. Oleh karena itu, suami istri harus memiliki kompetensi komunikasi antarbudaya, sehingga dapat memelihara keharmonisan dalam pernikahan. Tujuan dari penelitian ini adalah untuk mengeksplorasi faktor-faktor yang memfasilitasi kompetensi komunikasi antarbudaya pasangan pernikahan Tionghoa-Jawa, serta menganalisis bagaimana mereka menggunakan kompetensi tersebut untuk mengelola konflik. Penelitian ini dilakukan secara kualitatif dengan menganalisis hasil wawancara bersama responden menggunakan teori milik Tili dan Barker (2015) mengenai kompetensi komunikasi antarbudaya dan manajemen konflik pada pernikahan beda budaya, serta teori milik Lú Xiùfāng (2003) mengenai jenis konflik dalam pernikahan beda ras. Hasil penelitian menunjukkan bahwa faktor-faktor yang memfasilitasi kompetensi komunikasi antarbudaya pada suami istri Tionghoa-Jawa adalah pola pikir, lingkungan, gaya hidup, kelancaran berbahasa, gaya komunikasi, tingkat pendidikan, dan pekerjaan, sedangkan gaya manajemen konflik mereka adalah mengubah perspektif, berkomunikasi terbuka, dan memahami kepribadian dan kebiasaan pasangan.
PANDANGAN EVENT ORGANIZER X DAN Y DI SURABAYA MENGENAI PROSESI LAMARAN ETNIS TIONGHOA (DINGQIN)
Authors: Hartanto Florencya
Published: September 2023

Penelitian ini membahas pemahaman event organizer  di Surabaya mengenai 定亲 (pinyin: dìngqīn) serta makna dari prosesi dan perlengkapan yang harus dipersiapkan. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Dalam pengumpulan datanya, penulis melakukan wawancara dengan dua event organizer  yang telah berdiri lebih dari sepuluh tahun dan menangani lebih dari sepuluh dìngqīn. Terdapat enam nara sumber yang berasal dari dua event organizer  berbeda, yang masing-masing berkedudukan sebagai executive wedding consultant, project manager dan crew event organizer. Teknik pengumpulan data yang digunakan adalah wawancara semi terstruktur, sehingga penulis juga memberikan pertanyaan tambahan sesuai jawaban masing-masing narasumber. Di akhir penelitian, penulis menemukan beberapa temuan akan barang yang dipersiapkan seperti isi hantaran, pakaian, dan warna yang dipakai mengalami modernisasi dan akulturasi dengan budaya yang ada di Indonesia. Seiring berkembangnya zaman berbagai barang yang dipersiapkan mengalami ragam pembaharuan seperti adanya kue nastar, crispy cream, spiku hati, dan lapis Surabaya. Begitu pula dengan pemilihan pakaian qipao batik serta pemilihan warna yang tidak selalu menggunakan warna merah, tetapi menggunakan warna coklat, abu-abu, biru, dan lain-lain. Banyak orang Tionghoa Indonesia yang masih mempertahankan budaya Tionghoa walaupun dalam pelaksanaannya mereka memakai jasa event organizer. Pandangan yang tidak selalu sama antar event organizer, tidak mengurangi makna utama yang penting dari prosesi dingqin.Kata Kunci: Lamaran Tionghoa, Pandangan Event Organizer , Surabaya
Translation Strategies for Indonesian Version of The Adventure of Tintin Land of Black Gold
Authors: Dharmawan Eric
Published: September 2023

Knowing translation strategies allows the translator to select the best word choices when translating a text, which is especially important in entertainment media. The purpose of this research is to examine the translator's translation strategies used in translating the comic The Adventure of Tintin: Land of Black Gold into the comic Petualangan Tintin di Negeri Emas Hitam. Baker's (2018) eight translation strategies are used as the main theory of analysis in the study. The qualitative approach is used in this study's methodology. The writer examines each utterance and bubble in the book, excluding publisher information and mistakes or incorrect translations. According to the findings of this study, the translator only employs six of Baker's (2018) strategies. The loan word or loan word plus explanation, as well as translation by illustration, are not used in the translation. According to the findings of the study, translation by cultural substitution is the most used method to translate words that are unfamiliar to Indonesian readers. Following translation by omission, the translator omitted some sentences and words that were not necessary to translate into Indonesian to meet the main ideas of the sentence.
Depression and Suicide: A Book of Poetry about the Impact of Being Bullied
Authors: Christian Jonathan
Published: September 2023

In this creative work, I want to write a narrative poetry about bullying. Bullying often occurs and goes unnoticed and I want to raise its awareness by writing this book of poetry that revolves around bullying. Bullying has negative impacts on the young and old, such as depression and suicidal thoughts. Depression is a mental illness that affects someone morally and can change their behavior. In this creative work, I want to show the effects of bullying for teenagers, specifically those in high school. The main character, Icha, is bullied due to her social status at school. After being bullied, she becomes depressed and starts to have suicidal thoughts. In the end, she cannot take the pressure anymore and commits suicide. The result is a book of poetry consisting of twenty poems about the story of Icha and her being bullied.