bluuebunny/crossref_metadata_2025 huggingface dataset:
KERANGKA KONSEP ASSESSMENT OF LEARNING, ASSESSMENT FOR LEARNING, DAN ASSESSMENT AS LEARNING SERTA PENERAPANNYA PADA PEMBELAJARAN
Authors: Anisah Giati
Published: December 2022

This paper aims to explain the assessment of learning, assessment for learning, and assessment as learning-based internet learning, using library research and descriptive analysis method. Data obtained from various library sources, both books and journals, both printed and online, relate to the concepts of assessment of learning, assessment for learning, and assessment as learning. Based on the results of the analysis it was found that each approach has its contribution to student learning. This is because the objectives of each approach are different. Assessment of learning aims to consider student placement, grade promotion, and awarding certificates. While the assessment for learning aims to provide information to teachers about the achievement of student competencies so that teachers can make decisions about the next learning. On the other hand, assessment as learning aims to monitor and self-correct students independently by students. Judging from the benchmarks that are used as comparisons, in the assessment of learning the comparisons are other students. In the assessment for learning, there are criteria made by the teacher or expectations. Meanwhile, in assessment as learning, the benchmark used is the student's personal goals. The key assessors in the assessment of learning and assessment for learning are teachers, while in assessment as learning the key assessors are students.
Effectiveness and safety of thread embedding acupuncture for drug-resistant epilepsy outpatient in Viet Nam: a two-arm parallel design, randomized, controlled clinical trial
Authors: Nguyen Dan Van , Pham Thang Duc , Le An Thuy Minh
Published: December 2022

People with drug-resistant epilepsy (DRE) are at high risk of sudden unexpected deaths and lower quality of life. Experiments showed thread embedding acupuncture (TEA) has a seizure-reducing effect; however, data on DRE has been limited. This trial aimed to establish the efficacy and safety of TEA in people with DRE.

This was a two-arm, randomized controlled trial conducted on 30 DRE outpatients, which was fulfilled drug-resistant International League Against Epilepsy. The study was conducted at the Epilepsy clinic, Nguyen Tri Phuong Hospital, Ho Chi Minh City, from December 2020 to March 2022. All procedures for TEA and sham TEA (STEA) groups were identical. Seizure frequency diaries at the baseline and monthly follow-up visits by the participants. The Quality of Life in Epilepsy Inventory (QOLIE-31) scores at the baseline and 16 weeks; the National Hospital Seizure Severity Scale (NHS3) scores at the baseline, 8 weeks, and 16 weeks and the adverse events at monthly follow-up visits by a researcher.

A reduction in relative seizure frequency and the score change in QOLIE-31 and NHS3 in the TEA group were significantly different from the STEA group when analyzing each group separately (p<0.05). However, when comparing two groups, no significant difference was found in the change in seizure freedom and QOLIE-31 (p>0.05). Mild pain appeared in all participants after the intervention, but no serious adverse effects of TEA were observed.

TEA is a safe technique to use in people with DRE. However, the effectiveness of TEA needs further study.
Konseling Individual untuk meningkatkan konsep diri korban Bullying di Sekolah
Authors: Saputra Teuku Amnar , Amnar Zuriah
Published: December 2022

Kasus Bullying di sekolah harus menjadi perhatian semua kalangan terutama Guru Bimbingan dan Konseling yang memiliki kapasitas di bidang keilmuannya. Dalam rentang
tahun 2016-2020 KPAI telah menerima setidaknya 480 kasus yang Bullying disekolah. baru-baru ini juga kasus Bullying telah membuat siswa SD di Tasikmalaya meninggal Dunia. Tujuan penelitian ini adalah untuk meningkatkan konsep diri korban Bullying di sekolah melalui layanan konseling Individual. Penelitian ini merupakan penelitian kualitatif dengan metode deskriptif. Teknik pengumpulan data dilakukan dengan observasi dan melakukan wawancara konseling dengan SB sebagai salah satu korban bullying di SMK Negeri 1 Sigli dengan dampak yang berat. Analisis data dilakukan dengan cara penyajian, reduksi dan penarikan kesimpulan. Hasil penelitian menunjukan bahwa layanan konseling Individual memiliki pengaruh terhadap meningkatnya konsep diri SB sebagai korban Bullying. Pada awal pelaksanaan konseling SB masih menunjukkan sikap yang merasa rendah diri, tidak percaya diri dan menarik diri dari lingkungan. Pasca dilaksanakan konseling individual SB mulai membuka diri, memiliki semangat untuk berjuang dan mulai memiliki kepercayaan terhadap lingkungan sosialnya.
Anafilaxia no idoso: Particularidades na abordagem diagnóstica e terapêutica
Authors:   Serviço de Imunoalergologia, Centro Hospitalar Vila Nova de Gaia/Espinho, EPE, Vila Nova de Gaia, Portugal, Brosseron Lise , Ferreira Ana ,   Serviço de Imunoalergologia, Centro Hospitalar Vila Nova de Gaia/Espinho, EPE, Vila Nova de Gaia, Portugal
Published: December 2022

Com o aumento global da esperança média de vida e consequente prevalência crescente de patologias relacionadas com o envelhecimento, as doenças do foro alérgico não são exceção, sendo cada vez mais frequentes na prática clínica diária. A anafilaxia, enquanto reação de hipersensibilidade grave e potencialmente fatal, encontra -se associada a uma maior morbimortalidade nesta faixa etária, apresentando particularidades próprias que merecem ser destacadas, não só ao nível do diagnóstico, como do seu tratamento. A presença de múltiplas comorbilidades e consequente polimedicação, frequentemente com fármacos anti -hipertensores que podem não só condicionar reações anafiláticas, como também dificultar o tratamento destas, juntamente com o predomínio de sintomas cardiovasculares e outros fatores inerentes ao envelhecimento, conferem maior vulnerabilidade a esta população. Assim, torna -se pertinente identificar e sensibilizar os profissionais de saúde para a existência de características particulares da anafilaxia no idoso, de modo a permitir uma intervenção mais direcionada e uma melhoria no prognóstico destes doentes.
Digitalization as a New Paradigm for Managing the Development of Tourism in Ukraine in the Post-War Period
Authors:   V. N. Karazin Kharkiv National University, Нaponenko Hanna I. , Yevtushenko Olena V. ,   V. N. Karazin Kharkiv National University, Shamara Irina M. ,   V. N. Karazin Kharkiv National University, Vasylenko Vladyslav Yu. ,   V. N. Karazin Kharkiv National University
Published: December 2022

The article, based on the analysis of the main trends in the development of the tourism market in the context of global digitalization, which has intensified in the field of tourism and hospitality, substantiates structural changes in the tourist services market of Ukraine. The subject of the study is the introduction of digital technologies in the tourism industry of Ukraine in the post-war period. The purpose of the article is to study the features of the use of digital technologies in the tourism industry of Ukraine. The achievement of this goal was facilitated by the solution of the following tasks: to explore various forms of digitalization in the tourism industry of Ukraine; to offer an improved conception of managing the development of tourism in Ukraine in the post-war period. The article used methods of analysis and synthesis to summarize the development of digital technologies in tourism; method of comparative analysis – to compare the experience of international and national digital tourism development; prognostic methods – to outline the prospects for further development of digital tourism in Ukraine in the post-war period. The authors made an attempt to predict the prospects for digitalization of the tourism industry of our country based on the integration of several defining areas – AR (augmented reality), VR (virtual reality), AI (artificial intelligence), as well as robots and blockchain technologies. The article quite fully covers the issues of digital support of business processes in the field of tourism, analyzes the opportunities and prospects of tourism BigData, which are used for analyzing information, making forecasts, sustainable developing the tourism industry. The deliberate implementation of best practices in the field of digital technologies can help our country’s tourism industry implement strategies that become possible by the wider use of digital content and platforms. The provision of a modern business model will help stabilize the working environment in the post-war period, while stimulating an innovative approach in the field of tourism.
The Impact of the COVID-19 Pandemic on the Components of Germany’s Foreign Economic Activity
Authors:   V. N. Karazin Kharkiv National University, Kaverina Kateryna O. , Grygorova-Berenda Larysa I. ,   V. N. Karazin Kharkiv National University
Published: December 2022

Data from the German Federal Statistical Office show that economic production in this country decreased significantly in 2020, and gross domestic product decreased by 5% compared to the previous year. This means that the German economy suffered a deep recession in 2020 owing to the consequences of the COVID-19 pandemic, which disrupted the ten-year positive dynamics of economic growth. The purpose of the article is to define the features and characteristics of the impact of the COVID-19 pandemic on the components of Germany’s foreign economic activity. The place and role of Germany in world trade are considered. The impact of the consequences of the COVID-19 pandemic on the economic indicators of Germany and the European Union was examined, in particular, a significant drop in GDP in the second quarter of 2020. It is substantiated that the German economy is export-oriented and at the same time to some extent it is import-dependent. The impact of the COVID-19 pandemic on international trade in goods is outlined. In particular, since March 2020, there has been a significant drop in Germany’s exports and imports indicators owing to logistical problems and failures in supply chains. It is defined that motor vehicles and spare parts for them, as well as machinery and chemical products are the largest groups of goods among the exports and imports of Germany. Using the calculated RCA index, it was found out that according to these groups of goods, Germany also has comparative advantages. The dynamics of export and import volumes of the main commodity groups of Germany is presented. The prolonged impact of the pandemic, in particular the restrictive measures taken in the spring of 2019, on a significant drop in exports and imports in mid-April 2020 has been researched. It is proved that the high degree of openness of the German economy has increased macroeconomic stability in the context of the impact of the pandemic. It is found out that foreign economic activity is one of the important factors that helped the German economy cope with the COVID-19 crisis. A description of the successful EU policy in response to the consequences of the impact of the COVID-19 pandemic is given.
Assessing the Level of Budget Security of Ukraine in Conditions of Economic Instability
Authors:   Ivan Franko National University of Lviv, Sytnyk Natalia S. , Bednarchuk Viktoriia V. ,   Ivan Franko National University of Lviv
Published: December 2022

The purpose of the article is to study the theoretical foundations of budget security, highlight threats and directions for its strengthening, as well as an carry out an indicative analysis of the security situation in the budget sphere of Ukraine. Examining and summarizing the scientific works of many scholars, both economists and theorists, the authors’ own definition of the economic essence of «budget security» is developed. The basic foundations of theoretical identification of budget security of the State are allocated and substantiated. The indicators for assessing the level of budget security are outlined and the input information for their calculation is provided. The input information is analyzed to calculate the indicators of the state of budget security of Ukraine in 2016-2021. Critical and optimal values of indicators are highlighted. A list of indicators for determining the state of budget security of Ukraine in 2016-2021 was put to calculation. As a result, an integral indicator of Ukraine’s budget security was calculated. The level of budget security of Ukraine for 2022-2024 is prognosticated. Threats to ensuring the optimal level of budget security of Ukraine are allocated. It is proved that the main threats to Ukraine’s budget security can be determined by examining the ratio of total payments for servicing and repayment of public debt and the State budget revenues. The key directions of strengthening the budget security of our State have been identified. It is proved that ensuring the budget security of the State is one of the major tasks of implementing the strategic guidelines of the country’s development programs. Prospect for further research in this direction is to determine the degree of influence of business entities and the State institutions on the mechanisms for ensuring budget security. Further study and research of budgetary relations in the field of budget security can lead to the strengthening of traditional budget management.
The Problems of Financial Risks Management in the Risk Management System and the Methods for Solving
Authors:   Ivan Franko National University of Lviv, Petyk Liubov O. , Baskova Yuliia S. ,   Ivan Franko National University of Lviv
Published: December 2022

The article is concerned with the current methods of managing financial risks for an enterprise. The main directions of risk management and methods of neutralization of financial risks are considered. Risks are an important component of the economy, politics, social life of society, that is, they are present in all branches of activity and directions of any company, enterprise or organization operating in market conditions. Risks are associated with management and depend on the effectiveness, efficiency and validity of decisions. There are different definitions of the concept of «financial risk», depending on the position from which the author considers the category of «financial risk», he emphasizes and strengthens in his definition one or another specificity of the financial risk. In order to comprehensively understand financial risk, it is necessary to analyze its indicators. The article describes the main approaches to the definition of the concept of «financial risk», reveals the content of the risk management process, and describes the main methods of financial risks. To manage financial risks in an organization, the following basic methods are used: risk evasion (or, otherwise, its avoidance); prevention and control of possible losses (risk absorption); preservation of risk (taking over a risk); risk transfer. Opportunity and consequences are two important components of risk. A quantitative characteristic must take into account both of these elements. Another important characteristic of financial risk is the uncertainty of its consequences. This characteristic of financial risk is determined by the inability to change the quantitative financial result in the process of making financial decisions. The consequences of financial risk can be both positive and negative. In practice, the level of financial risk is most often assessed, first of all, by the amount of possible harm.
Formation of a Competitive Strategy of the Airport in Conditions of Uncertainty
Authors:   National Aviation University, Piletska Samira T.
Published: December 2022

The article states that airports as part of the transport system are the most important component of the national, regional and local infrastructure. It has been proven that the basis of the airport's competitive strategy is the need to ensure its effective operation by adapting to the uncertainty of the external environment; is a tool for the formation and maintenance of competitive advantage, the basis of optimal distribution and effective use of resources. The purpose of the study is to develop a system approach to the formation of a competitive strategy of airports in conditions of uncertainty of the influence of the external environment. It is proved that the system of forming the competitive strategy of the airport is presented in the form of the following subsystems: information support for forming the competitiveness of the airport; airport competitiveness management; planning and forecasting the airport's competitive strategy; complex adaptability to changing operating conditions. It is substantiated that the competitive strategy of the airport: determines the direction of development of the airport as a system, its mission, goals, main tasks, forms and content of activity; establishes a uniform system of priorities for the airport and determines directions for their implementation; is the basis for making decisions in the field of transport policy and the growth of airport capitalization, the development of target programs for the development of the infrastructural component; is considered as a basis for developing a unified vision of the airport's modern role and prospects for its development, interaction with executive and legislative authorities of various levels, business, and users of air transport services. Further developments are aimed at developing a mechanism for forming a competitive strategy of airports in conditions of uncertainty.
The Theoretical Aspects of Organizational Change Management at the Enterprise
Authors:   O. M. Beketov National University of Urban Economy in Kharkiv, Novikova Maryna M. , Borovyk Maryna V. ,   O. M. Beketov National University of Urban Economy in Kharkiv, Bubyrov Yehor A. ,   O. M. Beketov National University of Urban Economy in Kharkiv
Published: December 2022

The article studies the theoretical aspects of the introduction of organizational changes in the management of organizations and the definition of the essence of managing organizational changes in the activities of domestic enterprises and organizations. It is defined that changes are an integral part of the activities of domestic enterprises and organizations and most often consider external, internal and organizational changes. An analysis of theoretical approaches to the definition of the concept of «organizational changes» revealed the absence of a single generally accepted approach to the definition of this concept and made it possible to establish the main positions from which this concept is considered. It is determined that organizational changes characterize changes that occur in the activities of enterprises and organizations and are associated with the introduction of new forms and methods of management, taking into account the influence of factors of the external and internal environment, and are aimed at achieving the established goals of their activities. A generalizing classification of organizational changes is proposed, which: allows defining the substantial content of organizational changes; ensures the manageability of all processes for the implementation of organizational changes; creates opportunities for controlling organizational changes and serves as the basis for building a system for managing organizational changes in the management of the organization and is the starting point for understanding and developing levers of influence on resistance to organizational changes on the part of staff. It is defined that the management of organizational changes is a complex and multifaceted process that concerns all areas and directions of activities of enterprises and organizations. It is proposed to consider the management of organizational changes as a set of purposeful managerial actions in the organization’s management system aimed at transferring it from one state to another (desired state), which are carried out in accordance with certain development goals in conditions of variability of the external and internal environment. The purpose, main task, subject and object of management of organizational changes are defined. The positive results that domestic enterprises and organizations can obtain from the introduction of organizational changes in their activities are considered.
The Mechanism of Functioning of the State-Regulated Regional Heat Energy Markets
Authors:   O. M. Beketov National University of Urban Economy in Kharkiv, Kyzym Mykola O. , Kotliarov Yevhen I. ,   Research Centre of Industrial Problems of Development of NAS of Ukraine, Salashenko Tetiana I. ,   Research Centre of Industrial Problems of Development of NAS of Ukraine, Rudyka Olga V. ,   Research Centre of Industrial Problems of Development of NAS of Ukraine
Published: December 2022

The article is aimed at studying the current mechanism of the State regulation in the field of heat supply, identifying directions for its reform and developing proposals as to the formation of regional heat energy markets. To achieve this aim, the existing procedure for regulating economic activity in the field of heat supply, the mechanisms of functioning of electricity and natural gas markets are analyzed, the principles of functioning of regional heat energy markets are formulated. The study analyzes the content of the concept of «energy carriers market» (on the example of electric and heat energy and natural gas), as well as the basic principles of the functioning of national and regional markets of heat energy carriers. The current mechanism of the State regulation of economic activity in the field of heat supply and natural gas and electricity markets is examined. The direction of improving the regulation of economic activity in the field of heat supply is substantiated – further decentralization of managerial functions and concentration of powers at the level of local communities; creation of regional heat energy markets, which should be in the operational and strategic management of local self-government. The composition of instruments of the State regulation of the regional heat energy market is proposed. The result of the study is the development of proposals for the classification and composition of such groups of the State regulation instruments: regulatory (licensing, establishment of mandatory rules of economic activity, approval of standard forms of contracts, etc.), tariff (approval of the methodology for substantiating the level of tariffs), financial (provision of preferential economic conditions), and monitoring. Prospects for further research on this topic are: development of a model of the regional heat energy market along with a road-map for its construction; development of methodological provision necessary for the functioning of the regional heat energy market; substantiation of directions for improving domestic legislation on the regulation of economic activity in the field of heat supply.
Opportunities of Ukrainians’ Adaptation in Germany and Positive German Experience Implementation in the Development of Social Programs in Ukraine
Authors:   Educational and Scientific Institute «Karazin Banking Institute» of V. N. Karazin Kharkiv National University, Khrystoforova Olena M. , Tatar Maryna S. ,   National Aerospace University «Kharkiv Aviation Institute» named after M. Ye. Zhukovskiy, Sergienko Olena A. ,   National Technical University «Kharkiv Polytechnic Institute», Babenko Maksym V. ,   SI «UkrRDIwaterchannelproject»
Published: December 2022

Since the beginning of the war in Ukraine Germany is among the countries that have accepted the largest number of refugees from Ukraine. Despite the financial support of Germany to Ukrainian citizens, the solvency of Ukrainians, the sufficiency of their savings accumulated in Ukraine for living in Germany, the opportunities and problems for adaptation in Germany associated with the language barrier, the need for retraining of specialists in many specialties, problems for buying own housing in Germany, etc. remain a topical issue. The main indicators of the development of Germany and Ukraine, the comparison of living standards of the population in these countries, and the level of social security are considered in the article. The results of the study showed that the Ukrainian system of providing social assistance is imperfect, as there is no single Social Code, in contrast, there is an undeveloped institution of social inspection, and a low level of social benefits. At the same time, the level of protection of citizens in Ukraine is much lower than in Germany. In Ukraine, the wage level is not competitive. Ukrainians spend almost half of their income on the basic food needs. Therefore, there is no doubt that the post-war reconstruction of Ukraine should include both the necessary financing and the necessary reforms in Ukraine. The authors analyze the characteristic features of the German social assistance system, among which are: financing of the vast majority of social benefits at the expense of insurance contributions; unity and orderliness of social legislation; high level of development of the institute of social inspection, which is a guarantee for the objective assignment of social assistance; high level of social protection of refugees, which is a prerequisite for public peace and social stability; individual approach to the assignment of unemployment social assistance, which contributes to a lower level of unemployment compared to other European countries. The carried out research makes possible to substantiate the directions of the introduction of the German experience into the Ukrainian system of providing social services.
PENDIDIKAN KESEHATAN TENTANG KETIDAKNYAMANAN KEHAMILAN PADA TRIMESTER 3 DAN CARA MENGATASINYA
Authors: Amalia Rizki , Ulfa Siti Maria , Hikmah Nurul , Azizah Nor
Published: December 2022

Pendahuluan: Pada perkembangan normal kehamilan, ibu hamil akan mengalami banyak gejala ketidaknyamanan sebagai bentuk adaptasi fisiologis. Sebagian besar ibu hamil tidak melakukan apapun untuk mengurangi gejala ketidaknyamanan yang mereka rasakan. Hal ini dapat disebabkan karena kurangnya pengetahuan ibu hamil tentang cara mengurangi gejala ketidaknyamananTujuan: kegiatan pengabdian kepada masyarakat berupa penyuluhan ini bertujuan untuk meningkatkan pengetahuan dan pemahaman ibu hamil tentang ketidaknyamanan kehamilan pada trimester 3 dan cara mengatasinya.Metode: kegiatan diawali dengan memberikan kuesioner ketidaknyaman yang dirasakan ibu hamil dan pre test. Selanjutnya memberikan edukasi yang ditujukan kepada ibu hamil trimester 3 selama 30 menit dankemudian melakukan evaluasi dengan memberikan soal post test.Hasil: hasil kuesioner menunjukkan banyak peserta mengalami ketidaknyamanan pada kehamilan trimester 3 yaitu sering BAK, insomnia, konstipasi, kram pada kaki, keputihan, dan nyeri ulu hati. Rerata nilai post test peserta penyuluhan lebih tinggi (80,95) dibandingkan dengan nilai pre test (46,03). Hasil post test menunjukkan bahwa materi kegiatan edukasi ini dapat dipahami oleh pesertaKesimpulan: Perlu edukasi berkelanjutan tentang ketidaknyaman kehamilan trimester 1, 2, dan 3 serta cara mengatasinya yang dapat dilaksanakan  dalam kelas ibu hamil Kata kunci: ketidaknyamanan, ibu hamil, trimester 3
MANFAAT AROMA TERAPI PEPPERMINT UNTUK MUAL MUNTAH PADA IBU HAMIL DI DESA SEPUTIH RAMAN LAMPUNG TENGAH TAHUN 2022
Authors: Hatta Muhammad , . Nurliyani
Published: December 2022

Mual muntah pada kehamilan merupakan reaksi tubuh ibu terhadap perubahan  yang terjadi akibat kehamilan. Mual dan muntah merupakan salah satu tanda penting awal kehamilan. Mual dan muntah biasanya timbul sejak usia gestasi 5 minggu, yang dihitung berdasarkan hari pertama haid terakhir dan mencapai puncak pada usia gestasi 8 hingga 12 minggu serta berakhir pada usia gestasi 16 hingga 18 minggu (Pratami, 2014). Mual muntah bisa ditangani   dengan   non farmakologi inhalasi peppermint dan lemon. Aroma mint yang menyegarkan merupakan obat ampuh untuk mengatasi mual, melegakan saluran pernafasan dengan membuka kongesti hidung, tenggorokan, dan paru-paru. Rasa mint yang sejuk juga bisa membantu meringankan batuk, meringankan asma, dan mengusir kuman di mulut. Satu atau dua tetes minyak esensial lemon dalam  minyak atau diffuser di kamar tidur membantu untuk menenangkan dan meredakan Mual dan muntah kehamilan. Menurut sebuah studi, 40% wanita telah menggunakan aroma lemon untuk meredakan mual dan muntah, dan 26,5% dari mereka telah dilaporkan sebagai cara yang efektif untuk  mengontrol  gejala mereka.  Smith et  al.  juga telah  dianggap  segar lemon  bau membantu untuk Mual dan muntah kehamilan. Karena meningkatnya minat dalam penggunaan obat   herbal   pada   kehamilan,   ketersediaan   lemon   di   semua   musim.   (Parisa,   2014). Lokasi pengabdian masyarakat adalah di Seputih Raman, Lampung Tengah. Metode yang digunakan  yaitu  virtual  zoom  meeting  yang  diikuti  oleh  dosen  pembimbing,  kemudian penyuluhan lalu dilanjutkan dengan tanya jawab antar peserta dan pemateri selama acara berlangsung yang dihadiri oleh 7 ibu hamil.  Hasil dari kegiatan ini dapat dilihat bahwa target sasaran 100% tercapai dan dapat dikatakan berhasil. Manfaat dari penyuluhan ini peserta dapat memahami apa itu mual muntah pada kehamilan dan cara penanganan mual muntah. Kata Kunci : Inhalasi pepermin dan lemon,Mual muntah
Penyuluhan Kebutuhan Dasar Ibu Bersalin
Authors: Fathony Zaiyidah , I Mirawati , Ramdhaniah Nuru , Rahmah4 Alina
Published: December 2022

ABSTRAK Pendahuluan: Persalinan merupakan suatu hal fisiologis yang dialami oleh setiap ibu bersalin dan suatu hal yang menakjubkan bagi ibu dan keluarga. Namun persalinan juga menjadi saat yang menegangkan dan dapat menggugah emosi ibu dan keluarganya atau bahkan menakutkan bagi ibu. Upaya untuk mengatasi gangguan emosional dan pengalaman yang menegangkan tersebut sebaiknya dilakukan melalui asuhan sayang ibu selama persalinan dan proses kelahiran bayinya.Tujuan: Kegiatan pengabdian masyarakat berupa penyuluhan ini bertujuan untuk meningkatkan pengetahuan dan pemahaman ibu tentang kebutuhan dasar ibu bersalin.Metode: Kegiatan dimulai dengan perkenalan dan penjelasan tujuan kegiatan. Kemudian peserta diberikan soal pre test untuk mengetahui pemahaman peserta tentang kebutuhan dasar ibu bersalin. Selanjutnya peserta diberikan penyuluhan dengan cermah, tanya jawab dan diskusi. Setelah itu dilanjutkan dengan senam hamil. Pada sesi terakhir, peserta diberikan soal post test dengan pertanyaan yang sama dengan pre test untuk dilakukan penilaian terhadap peningkatan pengetahuan ibu.Hasil: rerata nilai post test peserta penyuluhan (88,9) lebih tinggi dibandingkan nilai pre test penyuluhan (66,7). Hasil post test yang dilakukan oleh peserta menunjukkan materi dapat diterima oleh peserta dengan baik.Kesimpulan:      Perlu pemberian edukasi atau penyuluhan secara terus-menerus tentang kebutuhan dasar ibu bersalin yang dapat dilaksanakan  dalam kelas ibu hamil. Kata kunci: kebutuhan dasar, ibu bersalin, kelas ibu hamil
Theoretical and legal understanding of the essence of state development in the context of globalization
Authors: Mahnovskyi Igor
Published: December 2022

Purpose. The purpose of the work is to highlight the essence and features of the development of the state in the context of globalization, as an inevitable process in the latest conditions of world coexistence, in the theoretical and legal aspect. Methodology. The methodology includes a comprehensive analysis and generalization of the available scientific and theoretical material and the formulation of relevant conclusions and recommendations. The following methods of scientific cognition were used during the research: critical-dialectical, systemic, functional, abstraction, prognostic. Results. In the research process, it was recognized that, undoubtedly, globalization realities play an important role in ensuring the proper regulatory arrangement of multifaceted social relations based on international legal standards developed by the global progressive community. Of course, one cannot do without the absorption of certain national aspects of state formation as a result of integration processes in the latest conditions of global coexistence, and therefore, taking into account the challenges of globalization, in order to ensure and approve significantly important priority national criteria, it is advisable to develop relevant and adequate legal concepts of a binding nature. Originality. In the process of research, the content of globalization is substantiated as a complex multifaceted social process of a planetary scale, which exerts an inevitable influence on the essential characteristics of states in general and the formation and development of their institutions in particular, which have the property of changing under the pressure of the spread of worldwide advanced systems of socio-political, socio-economic, spiritual - of a cultural nature determined by international legal norms, thereby making it necessary to unite the efforts of national states in order to overcome common human problems. Practical significance. The results of the study can be used in: research work - for further scientific developments devoted to the impact of globalization on state-building processes; law-making and law-enforcement activities - for the preparation and improvement of domestic normative legal acts and for the fulfillment by states of international obligations.
Overexpression of the key metabolic protein CPT1A defines mantle cell lymphoma patients with poor response to standard high-dose chemotherapy independent of MIPI and complement established highrisk factors
Authors: Gerdtsson Anna Sandström , Matos Rodrigues Joana de , Eskelund Christian Winther , Husby Simon , Grønbæk Kirsten , Räty Riikka , Kolstad Arne , Geisler Christian , Porwit Anna , Jerkeman Mats , Ek Sara
Published: December 2022

The variable outcome to standard immunochemotherapy for mantle cell lymphoma (MCL) patients is a clinical challenge. Established risk factors, including high MCL International Prognostic Index (MIPI), high proliferation (Ki-67), non-classic (blastoid/pleomorphic) morphology, and mutated TP53, only partly identify patients in need of alternative treatment. Deepened understanding of biological factors that influence time to progression and relapse would allow for an improved stratification, and identification of novel targets for high-risk patients. We performed gene expression analyses to identify pathways and genes associated with outcome in a cohort of homogeneously treated patients. In addition to deregulated proliferation, we show that thermogenesis, fatty acid degradation and oxidative phosphorylation are altered in patients with poor survival, and that high expression of carnitine palmitoyltransferase 1A (CPT1A), an enzyme involved in fatty acid degradation, can specifically identify high-risk patients independent of the established high-risk factors. We suggest that complementary investigations of metabolism may increase the accuracy of patient stratification and that immunohistochemistry- based assessment of CPT1A can contribute to defining high-risk MCL.
Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia
Authors: Kuusanmäki Heikki , Kytölä Sari , Vänttinen Ida , Ruokoranta Tanja , Ranta Amanda , Huuhtanen Jani , Suvela Minna , Parsons Alun , Holopainen Annasofia , Partanen Anu , Kuusisto Milla E.L. , Koskela Sirpa , Räty Riikka , Itälä-Remes Maija , Västrik Imre , Dufva Olli , Siitonen Sanna , Porkka Kimmo , Wennerberg Krister , Heckman Caroline A. , Ettala Pia , Pyörälä Marja , Rimpiläinen Johanna , Siitonen Timo , Kontro Mika
Published: December 2022

The BCL-2 inhibitor venetoclax has revolutionized the treatment of acute myeloid leukemia (AML) in patients not benefiting from intensive chemotherapy. Nevertheless, treatment failure remains a challenge, and predictive markers are needed, particularly for relapsed or refractory AML. Ex vivo drug sensitivity testing may correlate with outcomes, but its prospective predictive value remains unexplored. Here we report the results of the first stage of the prospective phase II VenEx trial evaluating the utility and predictiveness of venetoclax sensitivity testing using different cell culture conditions and cell viability assays in patients receiving venetoclax-azacitidine. Participants with de novo AML ineligible for intensive chemotherapy, relapsed or refractory AML, or secondary AML were included. The primary endpoint was the treatment response in participants showing ex vivo sensitivity and the key secondary endpoints were the correlation of sensitivity with responses and survival. Venetoclax sensitivity testing was successful in 38/39 participants. Experimental conditions significantly influenced the predictive accuracy. Blast-specific venetoclax sensitivity measured in conditioned medium most accurately correlated with treatment outcomes; 88% of sensitive participants achieved a treatment response. The median survival was significantly longer for participants who were ex vivo-sensitive to venetoclax (14.6 months for venetoclax-sensitive patients vs. 3.5 for venetoclax-insensitive patients, P<0.001). This analysis illustrates the feasibility of integrating drug-response profiling into clinical practice and demonstrates excellent predictivity. This trial is registered with ClinicalTrials.gov identifier: NCT04267081.
The problems of educational field experience for the students of elementary school teacher education study program during the pandemic
Authors: Setianti Tiyas Puji , Hartati Tatat
Published: December 2022

Change suddenly resulted in many educational institutions has not avoided congestion strategy, facilities, and infrastructure held distance learning or online learning. Limitations of media and the skill to operate the hardware and software as a means and infrastructures major can lead to learning that is done it becomes less efficient. Learning done online is rated less effective, so lowering the interaction between lecturers and students and the impact that the students felt, they are difficulty understanding the material and ask the material that they have yet to understand due to lack of concentration. This study will use the descriptive survey that seeks to explain or record the conditions that can describe the situation. In line with the research, objectives sought to describe the difficulties of the students of teacher training that is being or has been carried out in the course PPL SP in elementary schools when the pandemic COVID -19 takes place. The Data obtained will be analyzed using descriptive statistics. It is selected because it corresponds with the purpose of the descriptive method selected. Descriptive statistics serve to interpret the data more easily. Problems faced by students of PGSD Universitas Pendidikan Indonesia in the Campus Area of the Attack, among others, difficulties during the implementation of online learning that includes the process of opening and closing the lesson as well as delivering material to the students. Arouse students ' motivation was to be the task of the student PPL SP that difficult.
PRISONER OF WAR: SPECIAL STATUS IN THE CRIMINAL PROCEEDINGS OF UKRAINE AND THE RIGHT TO EXCHANGE
Authors: Kaplina Oksana
Published: December 2022

Background. This article is devoted to the relevant issue of the creation of appropriate normative regulation of criminal prosecution of prisoners of war who were captured during the armed conflict in Ukraine and their exchange. Despite the positive dynamics of destabilisation processes taking place all over the world, and in some places connected with the outbreak of military conflicts of an international nature, insufficient attention is paid to the issue of legitimising the process of exchange of prisoners of war in national legal systems.
Methods: The problem is complicated by the need to coordinate national legal mechanisms with the norms of international humanitarian and human rights laws, which cannot be competitive, but instead should have an integrative effect on national legal systems. Relying on the norms of international humanitarian law, the author concludes that prisoners of war, as legal participants in an armed conflict, due to the immunity (privilege) of the combatant, do not bear individual responsibility for the initiation of an aggressive war or participation in it and must be repatriated after its end, with the exception of cases where they committed so-called ‘general criminal’ crimes or violated the laws and customs of war. Moreover, the author’s position is illustrated by a concrete practical example of the first sentence of the Ukrainian court against a combatant.
Given that until July 2022, the Ukrainian criminal procedural law lacked a proper mechanism aimed at the exchange of prisoners of war, it is quite logical to direct the legal policy of the state to the development of the relevant procedural legislation.
Results: Considering the significant dangerous challenges that Ukraine has faced, and the amendment of the legislation, the author refer to the analysis of the factors that determined the special normative regulation of the procedural order of prisoners of war; analyse the criminal procedural status of the suspect-prisoner of war; and point to the differentiation of the procedural orders of such an exchange, the key criterion for the division of which is the procedural status of the person. Using the example of the first sentence in Ukraine to a Russian prisoner of war and relying on the norms of international humanitarian and national law, the author illustrate the specifics of the criminal liability of combatants. Evaluating the procedure of exchange of prisoners of war and criminal proceedings in absentia which were positively introduced in the legislation of Ukraine, it was concluded that the exchange is not an act of forgiveness, but an opportunity to return Ukrainian citizens, which is of the utmost importance in the hierarchy of values for the state.
Pengembangan kemampuan mengenal bilangan 1-10 melalui media pohon angka pada jenjang PAUD
Authors: Tonra Wilda Syam , Abdullah In Hi , Achmad Fatoni , Tonra Winda Syam , Ikhsan Muhammad , Umaternate Fira
Published: December 2022

Penelitian ini bertujuan untuk mendeskripsikan hasil belajar anak di Taman Kanak-Kanak Bunga Anggrek Mangoli Barat dalam mengenal angka setelah digunakan pohon angka sebagai alat peraga. Subjek penelitian dalam penelitian ini adalah 20 siswa dan guru TK Bunga Anggrek Mangoli Barat. Teknik pengambilan subjek purposive sampling penelitian berdasarkan pertimbangan-pertimbangan tertentu. Perwakilan subjek ada 3 siswa dengan perbedaan tingkatan kemampuan. Data penelitian ini dikumpulkan dengan teknik observasi, wawancara, proses belajar mengajar dan dokumentasi. Data hasil penelitian diambil secara kualitatif untuk menjelaskan hasil belajar anak Di Taman Kanak-Kanak Bunga Anggrek Mangoli Barat dalam memahami angka. Penelitian ini mengacu pada pengembangan kemampuan mengenal angka yaitu: 1) Menyebut dan Mengurutkan bilangan 2) Mengenalkan Lambang Bilangan 1-10.Hasil penelitian menunjukkan bahwa upaya yang dilakukan peneliti dalam pengembangan kemampuan mengenal angka adalah 1) Menstimulus pengembangan kognitif anak dalam hal pengenalan angka 1-10 pada anak usia dini 2) Menggunakan media untuk pengenalan angka 1-10 yaitu media pohon angka. Dengan Stimulus yang sesuai dengan perkembangan usia anak maka akan mendapatkan hasil yang diharapkan yaitu siswa mampu mengenal bilangan 1-10 setelah menggunakan media pohon angka.
Bilateral Extensive Syphilitic Punctate Inner Retinitis Triggering Macular Ischemia after Intravitreal Triamcinolone Injections
Authors: Jo Sung Hyun , Kim So Hee , Lee Seung Min , Byon Ik Soo , Lee Ji Eun , Kwon Han Jo
Published: December 2022

Purpose: To report a case of extensive syphilitic punctate inner retinitis (SPIR) triggering bilateral macular ischemia after intravitreal triamcinolone injections, and the multimodal retinal imaging findings.Case summary: A 69-year-old male patient with nonproliferative diabetic retinopathy was transferred to our hospital because of bilateral visual deterioration (to counting fingers) after the first intravitreal triamcinolone injection. Fundus examination revealed numerous yellow punctate precipitates in the superficial retinae, retinal arteriolitis, and vitritis. The punctate lesions and surrounding retinal regions showed decreased vascular density on optical coherence tomography angiography, and focal hypofluorescence on fluorescein angiography. The patient was positive for all of the Venereal Disease Research Laboratory test, the fluorescent treponemal antibody-absorption test, and Treponema pallidum hemagglutination; we diagnosed bilateral SPIR. After treatment with aqueous crystalline penicillin solutions (24 million units per day for 14 days), the punctate lesions reduced but arteriolitis progressed to obliterative vasculitis. After 6 months, the bilateral SPIR and vitritis resolved, and the bilateral visual acuity improved to 20/100. However, inner retinal and macular ischemia persisted because of capillary nonperfusion attributable to obliterative vasculitis.Conclusions: Extensive SPIR can develop after an initial intravitreal steroid injection; the inner retinal ischemia and visual loss may persist after treatment because obliterative vasculitis develops. Therefore, patients scheduled for intravitreal steroid injections should be screened for syphilis infection.
Pencegahan Primer Kekerasan Seksual Anak Melalui Intervensi Berbasis Keluarga di Kota Pontianak
Authors: Suwarni Linda , Selviana Selviana , Vidyastuti Vidyastuti
Published: December 2022

Sexual violence against children is a global phenomenon in various countries, including Indonesia. The lack of knowledge, attitudes, and self-efficacy of parents in education to prevent sexual violence in children is an obstacle in the primary prevention program for this incident. The purpose of this study was to determine the effectiveness of family-based interventions through Information and Education Communication (IEC) to prevent sexual violence in children on the knowledge, attitudes, and self-efficacy of parents. This research is a quasi-experimental research with a one-group pretest-posttest design. The sample size was 40 parents who have adolescence with a purposive sampling technique. Data were analyzed by paired t-test. The results of this study indicate that family-based intervention effectively increases parents' knowledge, attitudes and self-efficacy s in delivering education to prevent sexual violence in children (p value <0.05). Family-based intention as effective primary prevention of sexual violence against children.
Produksi Biogas dari Kotoran Sapi dengan Biodigester Kontinyu dan Batch: Review
Authors: Shitophyta Lukhi Mulia , Darmawan Masreza Hari , Rusfidiantoni Yestri
Published: December 2022

Sumber energi terbarukan perlu terus dikembangkan untuk menekan ketersediaan bahan bakar fosil yang sudah semakin menipis. Biogas merupakan salah satu energi alternatif dengan memanfaatkan limbah organik seperti kotoran sapi. Pengolahan kotoran sapi sebagai bahan baku biogas dapat menggunakan biodigester tipe kontinyu dan tipe batch. Biodigester kontinyu selalu berisi 80% umpan dari volume total (50 liter) dan 20% sisanya sebagai ruang gas. Biodigester tipe batch kapasitas 220 liter memiliki komposisi  kotoran sapi dan rumput gajah sebesar 25 kg : 25 kg dengan penambahan air 100 liter. Produksi biogas dilakukan selama 70 hari. Hasil penelitian menunjukkan bahwa biodigester kontinyu menghasilkan volume biogas total 17.520 ml dan kandungan CH4 51,37%, sedangkan untuk biodigester batch menghasilkan volume biogas total 66.484 ml dan kandungan CH4 31,37%. Uji nyala untuk biodigester kontinyu menunjukkan bahwa setelah hari ke-12 nyala api berwarna biru dan menyembur cukup kuat pada saat katup pengaturan gas dibuka dan dikenakan api, tetapi pada biodigester batch tidak menghasilkan nyala api karena kadar CH4 kurang dari 45%. Biodigester tipe kontinyu dengan kapasitas 50 L menghasilkan volume biogas lebih tinggi dibandingkan dengan tipe batch yang berkapasitas 220 liter