bluuebunny/crossref_metadata_2025 huggingface dataset:
Radiation-hygienic monitoring and assessment of the doses of the public residing on the radioactively contaminated territories of the Tula region
Authors: Lomovtsev A. E. , Sheveleva T. E. , Karpukhin A. S. , Volodicheva A. I.
Published: September 2019

Aim of the study: analysis of the results of the radiation-hygienic monitoring of the territories of the Tula region, contaminated due to the Chernobyl NPP accident; concentration of 137Cs and 90Sr in the locally produced food products and analysis of the annual effective dose of the public. Materials and methods: the study was performed in the Tula region in 1997-2018. It included the evaluation of the indicators of the radiation safety of more than 50 thousand samples of the main food products, sampled in the areas of the radioactive “Chernobyl” contamination of the region with the simultaneous measurement of the external gamma-radiation dose rate in the stationary control points. Additionally, it included the assessment of the dynamics of concentration of 137Cs and 90Sr in food products, maximal values of mean annual effective doses of the public and contribution of the collective dose from medical exposure into the structure of the annual collective dose of the public. Results: The study allowed estimating the concentration of 137Cs and 90Sr in the main local food products. Estimated values of gamma radiation dose rate were stable and laid in the range of normal variations specific to the middle latitudes of the European part of Russia. The values of maximal mean annual effective doses of the public indicate the stable radiation environment and do not exceed 1 mSv. It should be mentioned that the contribution of collective dose from medical exposure into the annual collective dose of the public as well as the values of mean individual effective doses from medical exposure are reducing with the increase in the number of X-ray examinations. Conclusions: The lack of exceedances of the permissible levels of 137Cs and 90Sr in the locally produced food products and the reduction of the mean annual effective dose of the public indicates the possibility of the transfer of the settlements affected by the Chernobyl NPP accident into the normal living conditions within the program of the transfer of the settlements from the “Chernobyl” zone.
210Po and 210Pb Isotopes Content in the Water of Artificial Lake of Istiklol City of the Republic of Tajikistan and their Bioaccumulation in the Fish
Authors: Miryakhyaev V. M. , Tilloboev K. I. , Nazarov Kh. M. , Makhmudova M. M. , Mirsaidov U. M.
Published: September 2019

The results of monitoring of 210Po and 210Pb isotopes in water of artificial lake (former uranium mine) of Istiklol city of the Republic of Tajikistan and their bio-accumulation are given. Fish living in this area is using as a food by local population. It has been found that the level of210Po isotope in the liver of fish, in particular of carаs fish, was relatively high. It has been defined that the annual effective radiation dose from gamma radiation and isotopic activity in water for human in the Istiklolcity exceeds the recommended annual threshold dose level (10 mSv).
Radioecological monitoring in the vicinity of Rostov NPP. The analysis of results of long-term investigations
Authors: Panov A. V. , Isamov N. N. , Kuznetsov V. K.
Published: September 2019

The purpose of this work was to assess the influence of the Rostov NPP (consisting of 4 units with VVER1000 reactors) on the radioecological situation in the region of the station location within 18 years from the start of the first power reactor. Based on the results of observations at the radioecological monitoring network established in 2001, which included seven control sites and five control points, the content of natural and artificial radionuclides in environmental objects, agricultural products and foodstuffs was analyzed. It was shown that over the entire period under consideration, the average content of 90Sr in the soils of agroecosystems of the 15-km zone of influence of the Rostov NPP varied within 1.7-7.4 Bq/kg, and 137Cs – 7.5-14.9 Bq/kg. It was not detected any trends to increase in the concentrations of artificial radionuclides in the soil throughout the considered territory. The variation range of the average content of natural radionuclides in soils was 561-634 Bq/kg for 40K, 23.4-27.5 Bq/kg for 226Ra and 32.7-35.9 Bq/kg for 232Th. The average concentration of 90Sr in the grain was in the range of 0.1-0.68 Bq/kg, and 137Cs – 0.23-0.54 Bq/kg. Even the maximum specific activity values of artificial radionuclides in food grain were below the SanPiN standards 55 times for 90Sr and 65 times for 137Cs. The maximum levels of 137Cs in vegetables and potatoes and vine crops were 80 times lower than the SanPiN standards. The maximum levels of specific activity of 90Sr in milk were more than 400 times lower than the SanPiN standard (25 Bq/kg), and for 137Cs (standard 100 Bq/kg) this difference was 600 times. Vegetable crops were characterized by minimal transfer factors (TFs) of radionuclides. TFs of 90Sr in vegetables, depending on the product type, was in the range of 0.04-0.17, and for 137Cs it was in the range of 0.008-0.2 (Bq/kg)/(kBq/m2 ). Maximum TFs of radionuclides were noted in grasses. TF of 90Sr in natural and perennial grass was 0.75-2.2, and for 137Cs it was 0.28-0.86 (Bq/kg)/(kBq/m2 ). The differences in transition factors between vegetables and grass reached 50 times, and on average, they were 10-20 times. It was noted that all types of crops accumulated 90Sr on average 2-5 times more in comparison to 137Cs ac cumulation. It was shown that the content of artificial radionuclides in the water of the Tsymlyansk reservoir is 163 and 183 times lower than the permissible level for 90Sr and 137Cs, respectively. The analysis of 18-year results of observations of the radioecological situation in the vicinity of the Rostov NPP allows to conclude that the operation of this NPP in normal mode and the commissioning of new power-generating units did not lead to a recorded increase in the content of artificial radionuclides in agricultural products, foodstuffs and environmental objects.
Trends of development and prediction of the doses from the internal exposure of the public of the Russian Federation and its critical groups in the distant post-Chernobyl NPP accident period
Authors: Bruk G. Ya. , Bazyukin A. B. , Bratilova A. A. , Yakovlev V. A.
Published: September 2019

An article is devoted to the peculiarities of exposure doses forming of adult population due to the main dose-forming foodstuffs in the remote period after Chernobyl accident. On an example of the Bryansk and Tula regions, we carried out the assessment of the effective purification half-periods of the main dose-forming food products (milk and mushrooms) from 137Cs due to its radioactive decay and natural self-purification and the assessment of the periods of half-reduction of the average annual effective internal doses for the population of the Bryansk region divided on the 137Cs soil surface activity actual in the corresponding year (based on whole body measurements data). Obtained results allowed fulfilling the prognosis of the internal doses for the population of the Bryansk region for the time period up to 2056.
Feline inflammatory bowel disease
Authors: STĘGIERSKA DIANA , PUCHALSKI ANDRZEJ , STANIEC MARTA , URBAN-CHMIEL RENATA , ŁOJSZCZYK ANNA , PYZIK EWELINA
Published: September 2019

Inflammatory bowel disease (IBD) is one of the most common causes of chronic clinical signs from the gastrointestinal tract, associated with histological evidence of inflammation in the lamina propria of the small and/or large intestine in cats. The underlying etiopathogenesis of this inflammation remains unclear. IBD is probably caused by a combination of environmental and immune factors in genetically susceptible individuals. The process of diagnosing IBD involves several steps and is based on the exclusion of other causes of gastrointestinal signs and on the confirmation of the presence of inflammatory infiltration in the intestinal wall by histopathological assessment of biopsies. The treatment is based on anti-inflammatory and immunosuppressive drugs. In addition, dietotherapy, antibiotics, antiparasitic drugs, prebiotics, probiotics and supplementation of vitamin b12 are also used. For most patients, the response to treatment is satisfactory, but the maintenance of clinical remission in most of them may require anti-inflammatory drugs for the rest of their lives.
Effects of exogenous Fibroblast Growth Factor-21 on characteristic parameters related to energy metabolism in dairy cows
Authors: CHEN YUANYUAN , WU QIAN , GAO YING , ZHANG HONGTAO , DONG ZHIHAO , LI RUIRUI , XU CHUANG
Published: September 2019

Negative energy balance (NEB) is a common pathological foundation of fatty liver and ketosis. Liver and fat tissue are the major organs of lipid metabolism, which is also a key metabolic pathway that regulates NEB development during the perinatal period. Fibroblast growth factor-21 (FGF-21) is a protein hormone that plays an important role in adipose lipid metabolism and liver gluconeogenesis. Our aim was to investigate the effects of exogenous FGF-21 on characteristic parameters related to energy balance in dairy cows. Ten non-pregnant, non-lactating Holstein-Friesian dairy cows were randomly allocated into two groups. The interventions were exogenous FGF-21 injection group received 1 ug/kg BW (body weight) of recombinant bovine FGF-21 by intravenous injection, and control group received physiological saline injections by intravenous injection. In comparison to saline injections, intravenous injections of FGF-21 either increased or tended to increase concentrations of FGF-21 (p < 0.05), BHBA (p < 0.05), adiponectin, leptin and HDL-C. FGF-21 injections decreased or tended to decrease concentrations of insulin, glucose, glucagon (p < 0.05), ALT/GPT (p < 0.05), AST/GOT (p < 0.05), urate, creatinine (p < 0.05), BUN, triglyceride (p < 0.05), T-CHO and LDL-C (p < 0.05). The results indicate that FGF-21 has only negative effects on the metabolites and metabolic hormones related to NEB in serum of dairy cows, but it has more beneficial effects on prominent adipokines, liver function index, renal function index, lipoprotein profiles related to the pathological changes that occurred in NEB.
Origin and protection of middle-European bees in Europe
Authors: MADRAS-MAJEWSKA BEATA , SKONIECZNA ŁUCJA
Published: September 2019

The population of the honey bee, Apis mellifera, continues to shrink. The middle-European bee, Apis m. mellifera, is particularly at risk in Europe. The drop in the number of middle-European bees is so huge that the insect is under the threat of extinction. Today, they live on small areas covered by the protection of genetic resources. Apis m. mellifera is protected mainly in areas where this species evolved: for instance, in Switzerland, Latvia, Norway, Sweden, Finland, Denmark, France, Germany, Poland or Russia. This paper presents methods used to preserve and protect Apis m. mellifera in Europe and research on the descent and original extent of the species. It also reviews opportunities created by the implementation of various types of programs for the protection of genetic resources of Apis m. mellifera and ways of employing morphological and genetic studies for the conservative breeding of middle-European bees. The paper demonstrates that the protection of Apis m. mellifera in Europe is necessary, considering the decreasing size, and the threat of hybridization, of this population. The use of the morphometric evaluation and DNA analysis methods have made it possible to track and compare likely directions of propagation of genes in the long history of evolution of bees. Moreover, these methods have given us better insight into the ongoing processes. The current use of these methods for reliable identification of bee breeds helps to protect Apis m. mellifera more effectively. European programs for the protection of genetic resources of bees are based on the following two main paradigms: the breeding of local isolated populations on islands and establishment of protected inland areas for the conservative breeding of contained swarms. All these programs share and are successful in achieving the goal that consists in the preservation of the characteristics of Apis m. mellifera as unchanged as possible, with retention of the maximum genetic diversity of the species.
Role of satellite cells in growth and regeneration of skeletal muscles
Authors: CIECIERSKA ANNA , SADKOWSKI TOMASZ , MOTYL TOMASZ
Published: September 2019

Postnatal growth and regeneration capacity of skeletal muscles is dependent mainly on adult muscle stem cells called satellite cells. Satellite cells are quiescent mononucleated cells that are normally located outside the sarcolemma within the basal lamina of the muscle fiber. Their activation, which results from injury, is manifested by mobilization, proliferation, differentiation and, ultimately, fusion into new muscle fibers. The satellite cell pool is responsible for the remarkable regenerative capacity of skeletal muscles. Moreover, these cells are capable of self-renewal and can give rise to myogenic progeny.
Mathematical modeling of the robot motion control system for monitoring deep sea communications
Authors: Zhukov Yuri , Khutornaia Ekaterina
Published: September 2019

The aim of the work is to determine the parameters of the mathematical model of the motion control system (MCS), which provides automatic monitoring of deep-sea communications with the minimum number of control devices of the MCS, due to which it is possible to use additional monitoring equipment. Mathematical models of the motion of an underwater robot are presented, block diagrams are constructed and the results of the motion of an underwater robot in the vertical and horizontal planes using the Matlab Simulink graphical simulation environment are obtained.
Construction of an algorithm for the analytical solution of the Kolmogorov-Feller equation with a nonlinear drift coefficient
Authors: Firsov Andrei , Zhilenkov Anton
Published: September 2019

The paper proposes a constructive method for solving the stationary Kolmogorov-Feller equation with a nonlinear drift coefficient. The corresponding algorithms are constructed and their convergence is justified. The basis of the proposed method is the application of the Fourier transform.
Simulation of T-junctions two phases separation characteristics
Authors: Wu Hao , Zhou Xiaojun , Ma Jingjing
Published: September 2019

When the two phases pass through the bifurcated pipe of the T-shaped pipe, the ratio of the two-phase of the main pipe and the branch pipe generally changes. This paper uses FLUENT to simulate the separation characteristics of a two-phase mixture of high-viscosity oil and water in a T-pipe, and studies the effect of different structures (the height of the branch pipe, the number of branch pipes, and the spacing of the branch pipes) on the separation characteristics. The results show that the number of branch pipes and the spacing of the branch pipes have a great influence on the separation efficiency of the two phases.
Control system design of multi-dimensional lumbar traction treatment bed
Authors: Luo Yanying , Liu Liang , Liu Yunjia , Ma Jingjing
Published: September 2019

A multi-dimensional lumbar traction treatment bed is designed with two degrees of freedom, which can realize controllable traction treatment of lumbar through flexion, extension and rotation motion. Two linear actuators are used to provide motion. Building a mathematical model of the device by least squares identification. PID controller and Kalman filter constitute two groups of control modes: (i) speed control; (ii) position control. Using MATLAB to perform simulation experiments. The results show that the designed controller can achieve high control accuracy. The motion speed of lumbar platform is stable and the position of traction treatment set by user is approached exactly, which ensuring the security and stability of this device.
A portable breast cancer detection system based on smartphone with infrared camera
Authors: Ma Jian , Shang Pengchao , Lu Chen , Meraghni Safa , Benaggoune Khaled , Zuluaga Juan , Zerhouni Noureddine , Devalland Christine , Al Masry Zeina
Published: September 2019

The traditional detection methods have the disadvantages of radiation exposure, high cost, and shortage of medical resources, which restrict the popularity of early screening for breast cancer. An inexpensive, accessible, and friendly way to detect is urgently needed. Infrared thermography, an emerging means to breast cancer detection, is extremely sensitive to tissue abnormalities caused by inflammation and vascular proliferation. In this work, combined with the temperature and texture features, we designed a breast cancer detection system based on smart phone with infrared camera, achieving the accuracy of 99.21 % with the k-Nearest Neighbor classifier. We compared the diagnostic results of the low resolution, originated from the phone camera, with the high resolution of the conventional infrared camera. It was found that the accuracy and sensitivity decreased slightly, but both of them were over than 98 %. The proposed breast cancer detection system not only has excellent performance but also dramatically saves the detection cost, and its prospect will be fascinating.
Monitoring the dynamics of exhausting exercises: the time-variability of acceleration
Authors: Montull Lluc , Vázquez Pablo , Hristovski Robert , Balagué Natàlia
Published: September 2019

Fatigue has been related to changes in the time-variability properties of coordinative variables during an exhausting isometric exercise [1]. In this study we aimed to investigate the qualitative changes in acceleration (kinematic collective variable) during exhausting running (n= 8) and ski mountaineering (n males = 5, n females = 5) exercises. Time-variability of acceleration was calculated using the Multifractal Detrended Fluctuation Analysis (MFDFA). Initial and final time series of both exercises were compared through Wilcoxon test. A reduction of MFDFA spectrum was observed in the final period in both exercises while the participants approached exhaustion, except for the male group of ski mountaineers that increased their speed at the end of the exercise. In runners, those who approached the psychobiological exhaustion showed a higher reduction in the MFDFA spectrum compared to those who did not. Although more research is needed to model this dynamic behavior in front of different constraints, time-variability of acceleration throughout a multifractal application seems to provide a valid information about the system adaptation during exhausting dynamic exercises.
Thorax measurement and analysis using electrical impedance tomography
Authors: Krčmařík David , Petrů Michal , Kočí Jan
Published: September 2019

The article deals with a novel method of visualizing interior of an object based on the measurements made on the boundary. Although an electrical impedance tomography is well established in areas where reference measurement can be easily made (difference method), it is still rather a theoretical approach for areas where reference cannot be taken (mainly in medicine). We have made a thorax measurement using difference method. The results show that electrical impedance tomography can provide valuable information for thorax visualization.
A technique for estimating geometrical synchronization of biomedical signals
Authors: Timofejeva Inga , McCraty Rollin , Atkinson Mike , Vainoras Alfonsas , Ragulskis Minvydas
Published: September 2019

A technique for the evaluation of geometrical synchronization between data signals based on optimal attractor reconstruction is demonstrated and validated using coupled chaotic logistic maps. The measure is then applied to estimate the degree of synchronization between human heart rate variability and Earth’s local geomagnetic activity.
Machine Processing of Milk in Dairy Production
Authors: Гербер Юрий , Gerber Yuriy , Гаврилов Александр , Gavrilov Alexander
Published: September 2019

For fermented milk products, consistency plays a leading role: it provides a quality product and shapes consumer demand. There have been numerous studies of the effect of the technological process on the properties of sour cream, kefir, etc. However, these studies were performed after the introduction of ferment. Thus, the effect of parameters of thermal and mechanical treatment during the primary stage on the physical and mechanical properties of fermented milk products remains understudied. The research objective was to confirm the following hypothesis: the parameters of homogenization during the primary stage affect the consistency of the fermented milk products. A set of experiments made it possible to expose the dependence of the rheologic properties of sourmilk products from the regime parameters of homogenization. The research featured initial mix for kefir and sour cream production. The milk was preheated to 45C in an Alfa-Laval pasteurizer and separated in an Alfa-Laval separator. The fat-free milk (1% of fat for kefir production) was heated in a pasteurizer to 55–60C and homogenized at 8–16 mPa. The homogenizing device of the manometer was additionally equipped with a phase separator delimiter of the S-homogenizer type. The acidity and viscidity for the sour cream and kefir were measured at different pressure values. The power expenses on homogenization depended on the pressure and the volume of milk. The pressure of homogenization proved to be a meaningful factor and affected the fermentation process. It rendered a substantial influence on the consistency and taste qualities of the fermented milk product. The experiment defined the optimal temperature of fermentation for kefir production. The optimization of pressure decreased the energy consumptions by 4.4 kW/h (24.4%) per ton. Solar thermal collectors were used to preheat the milk before homogenization, which decreased the specific energy consumption by 10.5 kW/h per ton. The new parameters lower the prime cost of the dairy products and raise their competitiveness.
Oat Protein Concentrate As Part of Curd Product for Sport Nutrition
Authors: Крапива Татьяна , Krapiva Tatyana , Уржумова Анна , Urzhumova Anna , Алисова Оксана , Alisova Oksana , Килина Ирина , Kilina Irina
Published: September 2019

In the modern society, terminology is considered as a significant factor that affects the communication process of scientists and specialists in the production and circulation of goods and services. The meanings of terms express scientific concepts that require an accurate definition in accordance with the level of development of a particular branch of knowledge. In the conditions of rapid industrial development, there is an interpenetration of terms and definitions. The development of catering industry resulted in its closer relationship with economy, market, and other food producing industries. The article provides definitions for the term ‘physical distribution of goods’ coined by various authors used to describe processes in the economy and trade. The existing terms mostly express the economic relations arising from the participants in the process when goods move from the producer to the consumer. These definitions consider only the economic component without taking into account the factors that affect the quality and safety of products and services, which is important for the food industry. The authors introduce a definition for the term ‘physical distribution of goods at a atering enterprise’. It takes into account the specifics and features of this process at catering establishments. The paper contains a simplified scheme of product distribution in the enterprise. The process includes five stages of the successive passage of raw materials and goods: delivery of raw materials and goods from the supplier to the enterprise – storage – relocation – production – sales. The authors identified and described features of physical distribution of goods in the conditions of food industry enterprises at all stages and recommended local regulatory documents that can help ensure the quality and safety of catering products.
Effect of Pumpkin Husks on Cracker Dough Fermentation
Authors: Зайцева Ирина , Zaitseva Irina , Шеламова Светлана , Shelamova Svetlana , Дерканосова Наталья , Derkanosova Natal'ya
Published: September 2019

An acute deficiency of food fibers is one of the most urgent problems of balanced diet. Food status can be increased by fortifying food formulae with natural raw ingredients that are rich in alimentary fibers. Dry residue of fruit and vegetable husks is a by-product of mother juice. Pumpkin husks were selected as an ingredient for cracker dough as a result of preliminary comparative researches of its structure and functional and technological properties. Pumpkin husks are a powdery product of cream color with an orange shade, humidity = 5.3%, cellulose = 19.6%, hemicelluloses = 3.5%, pectin = 5.4%. The research objective was to establish the effect of pumpkin husks on the dough fermentation process, since fermentation is one of the major factors that define the quality of the finished product. Methods of mathematical planning were used to calculate the optimal dose of pumpkin husks as 83.53 kg per ton of finished product. A set of experiments defined the biotechnological processes during dough maturation. Pumpkin husks proved to promote acid accumulation; they also increased the quantity of yeast cells and budding yeast cells. The effect can be due to the high content of digestible yeast cells of sugars. In addition, pumpkin husks are rich in magnesium, phosphorus, zinc, and other substances that produce a favorable impact on yeast microflora. The experimental dough sample demonstrated a better dimensional stability, which is connected with redistribution of moisture due to the water absorbing properties of food fibers and the reducing sugars in pumpkin husks. The cracker dough with pumpkin husks had a better plasticity, which helped to form the layered structure of the finished products. The effect can be explained by the more intensive process of acid accumulation. The results of the biotechnological fermentation processes of the cracker dough with pumpkin husks were confirmed by test baking. The paper features a comparative analysis of the crackers with pumpkin husks and the control sample. Introduction of pumpkin husks into the cracker formulation proved to have a favorable effect on the activity of yeast microflora, which improved the biotechnological processes and partially leveled the strengthening effect of food fibers of pumpkin husks on the cracker dough. As a result, the quality of the finished products met the standard requirements.
Market Research of Bottled Drinking Water
Authors: Павлов Игорь , Pavlov Igor , Ревякина Елизавета , Revyakina Elizaveta , Елесина Виктория , Elesina Victoria
Published: September 2019

Drinking water holds a valuable place in human ration. When choosing a water brand, the consumer is guided by a number of factors. Customers place various demands on a product. Thus, during the market launch the manufacturer needs to

know the consumer’s attitude to a given product. The determinant factors for product purchase include consumer’s knowledge of product trade names, information awareness, recognition of the product among other manufacturers, and advertising response. The marketing research was conducted in the city of Biysk (Altai Krai, Russia) and pursued the following goals: to determine public attitudes to bottled drinking water; to assess the factors that influence buying decisions; to evaluate the perspective presence of Altai Krai’s manufacturers at the bottled water market. The research was done through questionnaire survey and provided fairly complete information on consumers’ opinions, choices, and behavior. This survey covered different consumer categories, a total of 300 respondents of different age groups, income level, and social class. The survey results demonstrated that 56.6% of the respondents still use tap water. However, only 15.8% actually give their precedence to tap water value account; the remaining 84.2% can therefore be viewed as potential customers. The survey revealed that the major consumer’s criterion for water is the product price (42.8%). The second criterion in order of importance is the water quality, which constituted 16.7% of the total number of respondents. The paper contains data on consumers’ preferences by water manufacturers. The consumers were found to use water of manufacturers from other regions (51.6%). Only 42.4% gave their preference to local manufacturers, though Altai Krai is famous for its environmentally-clean drinking water sources. Price choices for drinking water were ascertained, and 53.6% of the respondents were found to be ready to pay 40 to 60 rubles per liter, which corresponds with the local manufacturers’ pricing policy. When asked if the quality of local water brands is trustworthy, the great majority of the consumers (86.4%) gave credit to the local manufacturers’ water quality. Based on the data on favourite brands, the most popular brands turned out to be the most promoted ones. The local manufacturers’ efforts in this direction require available persuasion means, such as ad placement in mass media and promotional events at sales places.
New Method for Efficiency Evaluation of Digital Technologies in Agricultural Sector
Authors: Рада Артём , Rada Artem , Федулова Елена , Fedulova Elena , Косинский Петр , Kosinsky Peter
Published: September 2019

The paper features digital technologies in satellite farming and introduces a quantitative methodology to evaluate various types of their effectiveness. The authors determined the main types of efficiency and components of evaluation and substantiated the algorithm of analysis. The paper also contains a list of related economic, environmental, and social components, as well as a set of formulas and dependencies. The methodology for assessing the effectiveness of digital technologies has a two-block structure. The first block determines the needs and opportunities for the implementation of digital technologies and helps to define the enterprises that may benefit from digital technologies. The second block involves a direct evaluation of the results and efficiency of the digital technologies to be implemented and substantiates management solutions. The paper describes approaches and procedures that help to assess the biological, technological, and economic benefits of digital technologies for an agricultural enterprise. The authors quantified the structure of the environmental effect of the introduction of digital technologies and introduced some dependencies can determine profitability and cost recovery indicators. The research used the methodological approach to assess the environmental and social efficiency of digital technologies for an agricultural enterprise. The approach corresponds with the requirements of sustainable agricultural development declared by the UN. The results can be used by enterprises of the agro-industrial complex and suppliers of digital technologies.
Pathos e argumentação como empoderamento no RAP
Authors: Barros Bruna Fernandes
Published: September 2019

O presente trabalho tem como objetivo identificar e analisar a argumentação por meio do estudo das emoções, aplicando as categorias de análise da patemização do discurso propostas por Charaudeau (2010) no rap, mais especificamente nas músicas Bate poeira e Você não vai, de Karol Conka. O objeto de análise foi escolhido tanto devido ao caráter subversivo do movimento hip hop (ao qual o rap pertence), quanto à forma de construção do próprio ritmo, que utiliza raciocínio rápido e lógico para elaboração de suas letras. O debate acerca de questões étnicas, de gênero e sociais na música de Conka foi o fator fundamental para a seleção das canções a serem analisadas. Neste trabalho, situaremos o hip hop historicamente e abordaremos a noção de pathos na argumentação para, assim, analisar o objeto. Entendemos que esse estudo se faz necessário a fim de compreender como as emoções e o possível despertar destas no público pode funcionar a fim de persuadir e/ou difundir uma ideia.
A A “inclusão” de homoafetivos na emergência do novo capitalismo: anúncios publicitários e os novos estudos de letramento na escola reflexiva.
Authors: De Lima Humberto Silva
Published: September 2019

Tendo como base a perspectiva da “virada cultural”, os novos estudos de letramento têm motivado movimentos convergentes para a desconstrução da ideia de que certos estados de coisas são considerados “normais”, enquanto outros são “desviantes” ou “marginais”, no que tange às práticas de letramento e sua produção e recepção. Nesse âmbito, o objetivo deste artigo é, por meio da análise do discurso crítica, proposta por Norman Fairclough (2001), discutir como a voz dos homoafetivos pode ser legitimada na multissemioticidade do gênero discursivo anúncio publicitário, ainda que essa legitimação seja posta em relevo pelos interesses do novo capitalismo na era pós-moderna.
Entre a “Grande Mãe” e a “Musa”, a “Louca”: embate de gênero e estereótipos na campanha publicitária “snickers, você não é você quando está com fome”
Authors: Coelho Barros Dulce Elena , Pedroso Almeida Lorena Martins , Carrenho Cocato Sarah Mariana Longo
Published: September 2019

Este artigo traz à memória dois dos mais expressivos estereótipos que acompanham a trajetória feminina junto à estrutura social, quais sejam, o da “grande mãe” e o da “musa”. O empreendimento histórico-discursivo será, aqui, rememorado a partir da campanha publicitária da barra de chocolate Snickers, que tem como slogan “Você não é você quando está com fome”. O enfoque se volta, mais vivamente, para duas das peças publicitárias videográficas, produzidas especificamente para serem veiculadas no Brasil, que se realizam com base numa perspectiva de embate de gênero masculino versus feminino. O anúncio publicitário “República” (2013) apresenta como protagonista a atriz Betty Faria e o anúncio publicitário “Vestiário”  (2015) conta com a participação da atriz, não menos consagrada, Claudia Raia. Com base nessas duas materialidades eleitas enquanto corpus analítico, buscamos, em consonância com os pressupostos da Análise Crítica do Discurso (ACD) de Norman Fairclough, desvelar significados relativos ao cenário no qual entre a figura da “mãe” e da “musa” se interpõe a figura da “louca” que, aparentemente salvaguardada no simulacro da representação teatral, perpetua representações sociodiscursivas  associadas ao pensamento patriarcal que identifica a mulher como naturalmente irritadiça, instável e psicologicamente patologizada.

PALAVRAS CHAVE: Análise Crítica do Discurso; Estereótipos de gênero; Identidade feminina.
Perspectivas metacognitivas e metalinguísticas para o ensino de leitura e escrita em língua materna
Authors: Botelho Patricia Ferreira , Neves Fabiana Esteves
Published: September 2019

Com o propósito de contribuir no debate sobre o ensino de leitura e escrita em língua materna no Brasil, reunimos alguns estudos, de base cognitivo-ecológica e metacognitiva, em forma de uma proposta geral de abordagem desses conteúdos, vistos aqui como habilidades processuais. Neste sentido, nosso trabalho visa refletir sobre as dificuldades e as habilidades de leitura e escrita dos alunos para, então, propor alternativas de desenvolvimento dessas atividades para professores e estudantes. Primeiramente, apresentamos alguns pressupostos em cognição, metacognição e gerenciamento metalinguístico que fundamentam a abordagem da leitura e da escrita. Em seguida, problematizamos as concepções sobre ler e escrever ainda vigentes na escola e oferecemos alternativas que consideram leitura e escrita como processos. Por fim, destacamos como componentes centrais da proposta as  estratégias metacognitivas e metalinguísticas, caminho de orientação sobre as formas como as pessoas podem pensar acerca das atividades que realizam. Em termos do ensino de leitura e de escrita, essas estratégias relacionam-se à importância de pôr em perspectiva a necessidade de negociação de informações focada no aprendizado.
Implicações pedagógicas do programa idiomas sem fronteiras no desenvolvimento profissional de professores/as em formação no NUCLI-UFPB
Authors: Bezerra Fábio Alexandre Silva , Cruz Fernandes da Costa Priscilla Thuany , Magalhães Ávila Paz Moreira Ana Gêrda
Published: September 2019

Devido ao importante papel de formação docente inicial do Programa Idiomas sem Fronteiras (BRASIL, 2014), com o intuito de fortalecer as licenciaturas do país na área de línguas, este artigo relata experiências de formação desenvolvidas no NucLi-UFPB, com destaque para o desenvolvimento da autonomia (FREIRE, 2014), da prática de reflexão crítica sobre o fazer docente (MAGALHÃES; CELANI, 2005) e das identidades docentes (LEFFA, 2001). A partir de entrevistas com agentes envolvidos no processo de formação docente, resultados gerais apontam para mudanças significativas no pensar e no agir dos mesmos no tocante ao processo de ensino-aprendizagem, possibilitando ricas oportunidades para seu desenvolvimento profissional (e pessoal) e para a construção de um repertório teórico-pedagógico essencial para suas (futuras) práticas docentes.
miR-146a-5p Regulated Cell Proliferation and Apoptosis by Targeting SMAD3 and SMAD4
Authors: Qiu Meiyu , Li Tao , Wang Binhu , Gong Hongbin , Huang Tao
Published: September 2019

Background:

microRNAs (miRNAs) are a small, endogenous non-coding RNAs that are
involved in post-transcriptional gene regulation of many biological processes, including embryo
implantation and placental development. In our previous study, miR-146a-5p was found expressed
higher in the serum exosomes of pregnant sows than non-pregnant. The research on miR-146a-5p
has been mainly related to human diseases, but there are few studies on its effects on the
reproduction of sows in early pregnancy.

Objective:

In this article, our motivation is to study the role of miR-146a-5p in the early pregnancy
of sows on the cell proliferetion and apoptosis by targeting SMAD3 and SMAD4.

Methods:

Bioinformatics software was used to identify the target genes of miR-146a-5p. The wildtype
and mutant-type recombinant plasmids of dual-luciferase reporter with 3'-UTR of Smad3 or 3'-
UTR of Smad4 were constructed, and co-transfected in porcine kidney cell (PK-15 cell) with miR-
146a-5p mimic, mimic-NC(M-NC), inhibitor and inhibitor-NC(IN-NC), then dual-luciferase
activity analysis, qRT-PCR and Western blot were performed to verify the target genes. After the
transfection of BeWo choriocarcinoma cell (BeWo cell) with miR-146a-5p mimic, M-NC, inhibitor
and IN-NC, the mRNA expression of Caspase-3, BAX and Bcl-2 was measured using qRT-PCR,
and the cell proliferation was measured using CCK-8 kit.

Results:

The luciferase, mRNA and protein expression of Smad3 in PK-15 cells treated by Smad3-
3'-UTR-W co-transfected with miR-146a-5p mimic were significantly lower than that with miR-
146a-5p M-NC, and the results of Smad4 were similar to Smad3, but the protein expression had a
trend to lower in mimic group. The expression level of Bcl-2 in the miR-146a-5p mimic group was
significantly lower than that in the miR-146a-5p M-NC group, but the expression pattern of
Caspase-3 was just opposite. The mimic of miR-146a-5p reduced the proliferation of BeWo cells,
however the inhibitor increased.

Conclusion:

Smad3 and Smad4 are the direct target genes of miR-146a-5p. The expression of
Smad3 and Smad4 were affected by the mimic and inhibitor of miR-146a-5p. miR-146a-5p affects
cell apoptosis and proliferation by regulating their target genes. This study provided new data to
understand the regulation mechanism of early pregnancy in sows.
Role of microRNAs in Chronic Lymphocytic Leukemia Pathogenesis
Authors: Javandoost Ehsan , Firoozi-Majd Ehsan , Rostamian Hosein , Khakpoor- Koosheh Mohammad , Mirzaei Hamid Reza
Published: September 2019

MicroRNAs (miRNAs) are a group of small endogenous non-coding RNAs involved in
many cancers and various cellular processes such as cellular growth, DNA methylation, apoptosis,
and differentiation. 13q14.3 chromosomal region contains miR-15 and miR-16 and deletion of this
region is a commonly reported aberration in Chronic Lymphoblastic Leukemia (CLL), suggesting
miRNAs involvement in CLL pathogenesis. MicroRNAs are known as oncogenes and tumor suppressors
in CLL which may also serve as markers of onset and progression of the disease. The most
prevalent form of leukemia diagnosed in adults in the western world, chronic lymphocytic leukemia,
accounts for one-third of all leukemias. CLL is characterized by the presence of B Cell Malignant
Clones in secondary lymphoid tissues, peripheral blood and bone marrow. The precise etiology of
CLL is remained to be known, however, a number of Chromosomal Abnormalities such as deletions
of 13q14.3, 11q and 17p and trisomy 12 have been detected. In this review, we offer our prospect on
how miRNAs are involved in the CLL pathogenesis and disease progression. Further understanding
of the underlying mechanisms and regulation of CLL pathogenesis has underscored the need for
further research regarding their role in this disease.
Next-Generation Sequencing: An Emerging Tool for Drug Designing
Authors: Tripathi Pooja , Singh Jyotsna , Lal Jonathan A. , Tripathi Vijay
Published: September 2019

Background:

With the outbreak of high throughput next-generation sequencing (NGS), the biological
research of drug discovery has been directed towards the oncology and infectious disease therapeutic areas, with
extensive use in biopharmaceutical development and vaccine production.

Method:

In this review, an effort was made to address the basic background of NGS technologies, potential applications
of NGS in drug designing. Our purpose is also to provide a brief introduction of various Nextgeneration
sequencing techniques.

Discussions:

The high-throughput methods execute Large-scale Unbiased Sequencing (LUS) which comprises of
Massively Parallel Sequencing (MPS) or NGS technologies. The Next geneinvolved necessarily executes Largescale
Unbiased Sequencing (LUS) which comprises of MPS or NGS technologies. These are related terms that
describe a DNA sequencing technology which has revolutionized genomic research. Using NGS, an entire human
genome can be sequenced within a single day.

Conclusion:

Analysis of NGS data unravels important clues in the quest for the treatment of various lifethreatening
diseases and other related scientific problems related to human welfare.
Recent Advances and Computational Approaches in Peptide Drug Discovery
Authors: Maurya Neha S. , Kushwaha Sandeep , Mani Ashutosh
Published: September 2019

Background:

Drug design and development is a vast field that requires huge investment along with a long duration for providing approval to suitable drug candidates. With the advancement in the field of genomics, the information about druggable targets is being updated at a fast rate which is helpful in finding a cure for various diseases.

Methods:

There are certain biochemicals as well as physiological advantages of using peptide-based therapeutics. Additionally, the limitations of peptide-based drugs can be overcome by modulating the properties of peptide molecules through various biomolecular engineering techniques. Recent advances in computational approaches have been helpful in studying the effect of peptide drugs on the biomolecular targets. Receptor – ligand-based molecular docking studies have made it easy to screen compatible inhibitors against a target.Furthermore, there are simulation tools available to evaluate stability of complexes at the molecular level. Machine learning methods have added a new edge by enabling accurate prediction of therapeutic peptides.

Results:

Peptide-based drugs are expected to take over many popular drugs in the near future due to their biosafety, lower off-target binding chances and multifunctional properties.

Conclusion:

This article summarises the latest developments in the field of peptide-based therapeutics related to their usage, tools, and databases.
Development of Secondary Osteoporosis in Teenage Girls with Menstrual Disorders
Authors: Popova-Petrosyan Elena V. , Kulanthaivel Shanmugaraj , Balasundaram Keerthanaa
Published: September 2019

Introduction:

Nowadays, the most common problem in teenage girls is them facing
menstrual disorders that develop secondary osteoporosis in their adolescent period. The locomotor
system disorder is noticed more often in girls with adolescence hormone pathology, than in the
population. This has an enormous human and socio-economic impact. Osteoporosis is estimated to
affect 200 million women worldwide.

Objective:

The aim of this research is to determine the development of secondary osteoporosis in
girls during their adolescent period.

Materials and Methods:

An analysis of 173 girls aged from 13 to 17 were under our supervision in
the children’s clinic sanatorium “Zdravnisa”. Girls were divided into four groups according to their
menstrual disorders.

Results:

As per the correlation analysis data, the influence of steroid hormones level on bone content
has a cumulative effect on girls.

Conclusion:

For patients with oligomenorrhea, secondary amenorrhea, and polymenorrhea, there
were disordered correlations of gonadotropic hormones. Correlations between calcium, phosphorus,
and magnesium are disordered, which can be proof of mineralization processes disorder. As per the
correlation analysis data for the girls with adolescence pathology, there were revealed direct average
correlation connections between the concentration of steroid hormones and structural-functional
properties of bony tissue. Low concentration of progesterone in the blood of girls with adolescence
pathology is one of the main reasons for bone content deficit, development of osteoporosis, and
scoliosis progression.
Recent Patents on the Triboelectrostatic Separation of Fly Ash
Authors: Haisheng Li , Wenping Wang , Yinghua Chen , Xinxi Zhang , Chaoyong Li
Published: September 2019

Background:

The fly ash produced by coal-fired power plants is an industrial waste. The
environmental pollution problems caused by fly ash have been widely of public environmental concern.
As a waste of recoverable resources, it can be used in the field of building materials, agricultural
fertilizers, environmental materials, new materials, etc. Unburned carbon content in fly ash has
an influence on the performance of resource reuse products. Therefore, it is the key to remove unburned
carbon from fly ash. As a physical method, triboelectrostatic separation technology has been
widely used because of obvious advantages, such as high-efficiency, simple process, high reliability,
without water resources consumption and secondary pollution.

Objective:

The related patents of fly ash triboelectrostatic separation had been reviewed. The structural
characteristics and working principle of these patents are analyzed in detail. The results can
provide some meaningful references for the improvement of separation efficiency and optimal design.

Methods:

Based on the comparative analysis for the latest patents related to fly ash triboelectrostatic
separation, the future development is presented.

Results:

The patents focused on the charging efficiency and separation efficiency. Studies show that
remarkable improvements have been achieved for the fly ash triboelectrostatic separation. Some
patents have been used in industrial production.

Conclusion:

According to the current technology status, the researches related to process optimization
and anti-interference ability will be beneficial to overcome the influence of operating conditions
and complex environment, and meet system security requirements. The intelligent control can not
only ensure the process continuity and stability, but also realize the efficient operation and management
automatically. Meanwhile, the researchers should pay more attention to the resource utilization
of fly ash processed by triboelectrostatic separation.